                         SEQUENCE LISTING

<110>  Genizon BioSciences

<120>  GENEMAP OF THE HUMAN GENES ASSOCIATED WITH CROHN'S DISEASE

<130>  GENI-022/01WO

<160>  14083

<170>  Genizon Biosciences InHouse Software

<210>  1
<211>  2262
<212>  DNA
<213>  Homo sapiens

<400>  1
acataatgaa gtgtccgatg ctaaggtcaa ggctgggcca ggaaagcgtc cactgtgggc     60

ccatgttcat ccaggtctcc cggcccctgc ccctgtggag ggacaataga cagactccat    120

ggctgctgtc ccttcgaggg gagctggtgg cttctcttga agacgccagc ctgatgggac    180

tgtatgtgga catgaatgcc accactgtca ccgtccaaag cccgagacaa ggccttcttc    240

agaggtggga ggtcagtggt gggcagcagg ctctgccagg agtgtcattc cagccagagt    300

cggaggtctt agttcacatc cccaagcaga gactgggtct agtcaaaaga ggttcctaca    360

ttgaggaaac cctgagcctc agactcctcc gagtccacca gtccaacatc tttatggtga    420

ctgagaacaa ggactttgtg gtggtcagca ttccggcggc cggggtgctc caggtccagc    480

gatgccaaga agtcggagga accccgggaa cacaagcttt ctatagggta gacctgagcc    540

tggaatttgc cgagatggct gccccggtcc tctggacagt ggagagcttc ttccagtgtg    600

tgggttcagg aacagagccg cctgcctcaa ctgctgcact gaggaccact ccctccccac    660

catccccagg accagagacc cctccagcgg gagtgccacc tgctgcttcc tcccaggtgt    720

gggctgcagg gccagctgcc caggaatggc tttctcggga cctcctgcac cggccttccg    780

acgcactggc caaaaagggg cttggaccat tcctgcaaac agccaaaccg gcgagaagag    840

gccagacatc tgcctccatt ctccccagag tggtgcaagc tcagcgaggt ccccagcctc    900

ccccagggga agcagggatc cctggacacc ccacacctcc agccacgctc ccctcggagc    960

ctgtagaggg tgtccaggct agtccctggc ggccacgtcc agtcttgcca acgcacccgg   1020

ctctgaccct gcccgtgtcc tcagatgcct cctctccttc accgccagcc ccgaggcctg   1080

aacgacctga atcacttctg gtctcaggac catctgtcac cctgactgaa ggtctaggaa   1140

ctgtgaggcc tgaacaggac cccgccaagt ctccaggaag tcccctcctg ctgagaggct   1200

tgtcaagcgg ggatgtggct gcacctgagc ccatcatggg ggagcccggc caagccagtg   1260

aggagttcca gccattggcg aggccctggc gggccacact ggctgcagag gagctggttt   1320

ctcaccgttc tcccggagag ccccaggaaa cgtgctctgg aacggaggtg gagaggccac   1380

gccagacagg gcctggtctc cccagggagg gggccagggg gcacatggac ctttcatcct   1440

cagaaccaag ccaggacata gaggggccgg gactctccat cctgccagcg agggatgcca   1500

cattctccac cccaagtgtg aggcagccag accccagtgc ctggctgagt tcaggacctg   1560

aactcaccgg gatgcccagg gtgaggctgg cagcgcccct ggcagttctt cctatggaac   1620

ctctgccacc agaacctgtt cgcccagcag ctcttctgac acccgaagcc tcatctgtgg   1680

gagggccaga ccaggcccga tacctggagt cagcccctgg ctggcctgtg ggccaggagg   1740

agtggggggt tgcacacacg tccagccctc catccacgca aaccctgagc ctgtgggctc   1800

ccacaggagt gttgctaccc agcctggtgg agcttgaata ccccttccag gctggccggg   1860

gggcctcact ccagcaggag ctgacagagc ccaccttggc cctcagtgct gaaagccaca   1920

ggcctcctga gcttcaagac agtgtggagg ggctttctga gaggccctca cgctgagcct   1980

ccatggagac tccaggcagc cggtaccccg ctggcttgga cggccccagt gaccctcagt   2040

gacccagctg tccccaggct ccctggctta gatgcccagc tgtggctggg tacagtgttc   2100

tgggccggaa gagcactcac tcagtgcttc cctggaaagg tggaccccca gacgcccacc   2160

tccaggcaga cccatcactg gaagtgggat ttgaaatgca gccaagaaga ggagaccgtc   2220

ggcaacgccc gcccggaaca agaaataaat aaataaataa tc                      2262


<210>  2
<211>  656
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Cys Pro Met Leu Arg Ser Arg Leu Gly Gln Glu Ser Val His 
1               5                   10                  15


Cys Gly Pro Met Phe Ile Gln Val Ser Arg Pro Leu Pro Leu Trp Arg 
            20                  25                  30


Asp Asn Arg Gln Thr Pro Trp Leu Leu Ser Leu Arg Gly Glu Leu Val 
        35                  40                  45


Ala Ser Leu Glu Asp Ala Ser Leu Met Gly Leu Tyr Val Asp Met Asn 
    50                  55                  60


Ala Thr Thr Val Thr Val Gln Ser Pro Arg Gln Gly Leu Leu Gln Arg 
65                  70                  75                  80


Trp Glu Val Ser Gly Gly Gln Gln Ala Leu Pro Gly Val Ser Phe Gln 
                85                  90                  95


Pro Glu Ser Glu Val Leu Val His Ile Pro Lys Gln Arg Leu Gly Leu 
            100                 105                 110


Val Lys Arg Gly Ser Tyr Ile Glu Glu Thr Leu Ser Leu Arg Leu Leu 
        115                 120                 125


Arg Val His Gln Ser Asn Ile Phe Met Val Thr Glu Asn Lys Asp Phe 
    130                 135                 140


Val Val Val Ser Ile Pro Ala Ala Gly Val Leu Gln Val Gln Arg Cys 
145                 150                 155                 160


Gln Glu Val Gly Gly Thr Pro Gly Thr Gln Ala Phe Tyr Arg Val Asp 
                165                 170                 175


Leu Ser Leu Glu Phe Ala Glu Met Ala Ala Pro Val Leu Trp Thr Val 
            180                 185                 190


Glu Ser Phe Phe Gln Cys Val Gly Ser Gly Thr Glu Pro Pro Ala Ser 
        195                 200                 205


Thr Ala Ala Leu Arg Thr Thr Pro Ser Pro Pro Ser Pro Gly Pro Glu 
    210                 215                 220


Thr Pro Pro Ala Gly Val Pro Pro Ala Ala Ser Ser Gln Val Trp Ala 
225                 230                 235                 240


Ala Gly Pro Ala Ala Gln Glu Trp Leu Ser Arg Asp Leu Leu His Arg 
                245                 250                 255


Pro Ser Asp Ala Leu Ala Lys Lys Gly Leu Gly Pro Phe Leu Gln Thr 
            260                 265                 270


Ala Lys Pro Ala Arg Arg Gly Gln Thr Ser Ala Ser Ile Leu Pro Arg 
        275                 280                 285


Val Val Gln Ala Gln Arg Gly Pro Gln Pro Pro Pro Gly Glu Ala Gly 
    290                 295                 300


Ile Pro Gly His Pro Thr Pro Pro Ala Thr Leu Pro Ser Glu Pro Val 
305                 310                 315                 320


Glu Gly Val Gln Ala Ser Pro Trp Arg Pro Arg Pro Val Leu Pro Thr 
                325                 330                 335


His Pro Ala Leu Thr Leu Pro Val Ser Ser Asp Ala Ser Ser Pro Ser 
            340                 345                 350


Pro Pro Ala Pro Arg Pro Glu Arg Pro Glu Ser Leu Leu Val Ser Gly 
        355                 360                 365


Pro Ser Val Thr Leu Thr Glu Gly Leu Gly Thr Val Arg Pro Glu Gln 
    370                 375                 380


Asp Pro Ala Lys Ser Pro Gly Ser Pro Leu Leu Leu Arg Gly Leu Ser 
385                 390                 395                 400


Ser Gly Asp Val Ala Ala Pro Glu Pro Ile Met Gly Glu Pro Gly Gln 
                405                 410                 415


Ala Ser Glu Glu Phe Gln Pro Leu Ala Arg Pro Trp Arg Ala Thr Leu 
            420                 425                 430


Ala Ala Glu Glu Leu Val Ser His Arg Ser Pro Gly Glu Pro Gln Glu 
        435                 440                 445


Thr Cys Ser Gly Thr Glu Val Glu Arg Pro Arg Gln Thr Gly Pro Gly 
    450                 455                 460


Leu Pro Arg Glu Gly Ala Arg Gly His Met Asp Leu Ser Ser Ser Glu 
465                 470                 475                 480


Pro Ser Gln Asp Ile Glu Gly Pro Gly Leu Ser Ile Leu Pro Ala Arg 
                485                 490                 495


Asp Ala Thr Phe Ser Thr Pro Ser Val Arg Gln Pro Asp Pro Ser Ala 
            500                 505                 510


Trp Leu Ser Ser Gly Pro Glu Leu Thr Gly Met Pro Arg Val Arg Leu 
        515                 520                 525


Ala Ala Pro Leu Ala Val Leu Pro Met Glu Pro Leu Pro Pro Glu Pro 
    530                 535                 540


Val Arg Pro Ala Ala Leu Leu Thr Pro Glu Ala Ser Ser Val Gly Gly 
545                 550                 555                 560


Pro Asp Gln Ala Arg Tyr Leu Glu Ser Ala Pro Gly Trp Pro Val Gly 
                565                 570                 575


Gln Glu Glu Trp Gly Val Ala His Thr Ser Ser Pro Pro Ser Thr Gln 
            580                 585                 590


Thr Leu Ser Leu Trp Ala Pro Thr Gly Val Leu Leu Pro Ser Leu Val 
        595                 600                 605


Glu Leu Glu Tyr Pro Phe Gln Ala Gly Arg Gly Ala Ser Leu Gln Gln 
    610                 615                 620


Glu Leu Thr Glu Pro Thr Leu Ala Leu Ser Ala Glu Ser His Arg Pro 
625                 630                 635                 640


Pro Glu Leu Gln Asp Ser Val Glu Gly Leu Ser Glu Arg Pro Ser Arg 
                645                 650                 655


<210>  3
<211>  595
<212>  DNA
<213>  Homo sapiens

<400>  3
atggcctctg gtgtggctat ctctgatggt gtcatcaagg tgttcactga catgacagtg     60

ggcaaatctt cgacgccaga ggaggtgaag aagcgcaaga aaatggtgct gctcttctgc    120

ctgagtgagg gtgagaagaa catcgccctg gaggagggcg aggagaccct ggtggatgac    180

atgggctgga ccgttgacaa cccctacacc acctttgcca agatgctgcc agacaaagac    240

tgctgctgtg tcctctgagg tgacgcaacc tatgggtcca aggagagcaa ggaggacctg    300

gtatttatct tctgggcccc tgagtctgta ccccttaagg gcaaaatgat ctatgccagc    360

tctaaggatg ccatcaagaa gctgacaggg aagctgacag ggatcaagca tgaacaagca    420

aactgctaca agaggtcaag gaccatggca gaccgggcga gaagctggga gcggcgctgt    480

catctccctg gagggcacgc cttatttaaa caacagctcc agggtggtcc ttgcaggttc    540

tctgagtgag ctgtgtacca gtgatgtttg ccctggcttt ggcgtttctg tttga         595


<210>  4
<211>  4236
<212>  DNA
<213>  Homo sapiens

<400>  4
ggtgggcggg gggaggaggc ggccctagcg ccattttgtg ggagcgaagc ggtggctggg     60

ctgcgcttgg gtccgtcgct gcttcggtgt ccctgtcggg cttcccagca gcggcctagc    120

gggaaaagta aaagatgtct gaatatattc gggtaaccga agatgagaac gatgagccca    180

ttgaaatacc atcggaagac gatgggacgg tgctgctctc cacggttaca gcccagtttc    240

caggggcgtg tgggcttcgc tacaggaatc cagtgtctca gtgtatgaga ggtgtccggc    300

tggtagaagg aattctgcat gccccagatg ctggctgggg aaatctggtg tatgttgtca    360

actatccaaa agataacaaa agaaaaatgg atgagacaga tgcttcatca gcagtgaaag    420

tgaaaagagc agtccagaaa acatccgatt taatagtgtt gggtctccca tggaaaacaa    480

ccgaacagga cctgaaagag tattttagta cctttggaga agttcttatg gtgcaggtca    540

agaaagatct taagactggt cattcaaagg ggtttggctt tgttcgtttt acggaatatg    600

aaacacaagt gaaagtaatg tcacagcgac atatgataga tggacgatgg tgtgactgca    660

aacttcctaa ttctaagcaa agccaagatg agcctttgag aagcagaaaa gtgtttgtgg    720

ggcgctgtac agaggacatg actgaggatg agctgcggga gttcttctct cagtacgggg    780

atgtgatgga tgtcttcatc cccaagccat tcagggcctt tgcctttgtt acatttgcag    840

atgatcagat tgcgcagtct ctttgtggag aggacttgat cattaaagga atcagcgttc    900

atatatccaa tgccgaacct aagcacaata gcaatagaca gttagaaaga agtggaagat    960

ttggtggtaa tccaggtggc tttgggaatc agggtggatt tggtaatagc agagggggtg   1020

gagctggttt gggaaacaat caaggtagta atatgggtgg tgggatgaac tttggtgcgt   1080

tcagcattaa tccagccatg atggctgccg cccaggcagc actacagagc agttggggta   1140

tgatgggcat gttagccagc cagcagaacc agtcaggccc atcgggtaat aaccaaaacc   1200

aaggcaacat gcagagggag ccaaaccagg ccttcggttc tggaaataac tcttatagtg   1260

gctctaattc tggtgcagca attggttggg gatcagcatc caatgcaggg tcgggcagtg   1320

gttttaatgg aggctttggc tcaagcatgg attctaagtc ttctggctgg ggaatgtaga   1380

cagtggggtt gtggttggtt ggtatagaat ggtgggaatt caaatttttc taaactcatg   1440

gtaagtatat tgtaaaatac atatgtacta agaattttca aaattggttt gttcagtgtg   1500

gagtatattc agcagtattt ttgacatttt tctttagaaa aaggaagagc taaaggaatt   1560

ttataagttt tgttacatga aaggttgaaa tattgagtgg ttgaaagtga actgctgttt   1620

gcctgattgg taaaccaaca cactacaatt gatatcaaaa ggtttctcct gtaatatttt   1680

atccctggac ttgtcaagtg aattctttgc atgttcaaaa cggaaaccat tgattagaac   1740

tacattcttt accccttgtt ttaatttgaa ccccaccata tggatttttt tccttaagaa   1800

aatctccttt taggagatca tggtgtcaca gtgtttggtt cttttgtttt gttttttaac   1860

acttgtctcc cctcatacac aaaagtacaa tatgaagcct tcatttaatc tctgcagttc   1920

atctcatttc aaatgtttat ggaagaagca cttcattgaa agtagtgctg taaatattct   1980

gccataggaa tactgtctac atgctttctc attcaagaat tcgtcatcac gcatcacagg   2040

ccgcgtcttt gacggtgggt gtcccatttt tatccgctac tctttatttc atggagtcgt   2100

atcaacgcta tgaacgcaag gctgtgatat ggaaccagaa ggctgtctga acttttgaaa   2160

ccttgtgtgg gattgatggt ggtgccgagg catgaaaggc tagtatgagc gagaaaagga   2220

gagagcgcgt gcagagactt ggtggtgcat aatggatatt ttttaacttg gcgagatgtg   2280

tctctcaatc ctgtggcttt ggtgagagag tgtgcagaga gcaatgatag caaataatgt   2340

acgaatgttt tttgcattca aaggacatcc acatctgttg gaagactttt aagtgagttt   2400

ttgttcttag ataacccaca ttagatgaat gtgttaagtg aaatgatact tgtactcccc   2460

ctaccccttt gtcaactgct gtgaatgctg tatggtgtgt gttctcttct gttactgata   2520

tgtaagtgtg gcaatgtgaa ctgaagctga tgggctgaga acatggactg agcttgtggt   2580

gtgctttgca ggaggacttg aagcagagtt caccagtgag ctcaggtgtc tcaaagaagg   2640

gtggaagttc taatgtctgt tagctaccca taagaatgct gtttgctgca gttctgtgtc   2700

ctgtgcttgg atgcttttta taagagttgt cattgttgga aattcttaaa taaaactgat   2760

ttaaataata tgtgtctttg ttttgcagcc ctgaatgcaa agaattcata gcagttaatt   2820

cccctttttt gacccttttg agatggaact ttcataaagt ttcttggcag tagtttattt   2880

tgcttcaaat aaacttattt gaaaagttgt ctcaagtcaa atggattcat cacctgtcat   2940

gcattgacac ctgataccca gacttaattg gtatttgttc ttgcattggc caaagtgaaa   3000

attttttttt ttcttttgaa atctagtttt gaataagtct gggtgaccgc acctaaaatg   3060

gtaagcagta ccctccggct ttttcttagt gcctctgtgc atttgggtga tgttctattt   3120

acatggcctg tgtaaatctc cattgggaag tcatgccttc taaaaagatt cttatttggg   3180

ggagtgggca aaatgttgat tattttctaa tgctttgtag caaagcatat caattgaaaa   3240

gggaatatca gcaccttcct agtttgggat ttgaaaagtg gaattaattg cagtagggat   3300

aaagtagaag aaaccacaaa ttatcttgtg cctgaaatcc attaagaggc ctgatagctt   3360

taagaattag ggtgggttgt ctgtctggaa gtgttaagtg gaatgggctt tgtcctccag   3420

gaggtggggg aatgtggtaa cattgaatac agttgaataa aatcgcttac aaaactcaca   3480

ctctcacaat gcattgttaa gtatgtaaaa gcaataacat tgattctctg ttgtactttt   3540

ttgtaactaa ttctgtgaga gttgagctca ttttctagtt ggaagaatgt gatatttgtt   3600

gtgttggtag tttacctaat gcccttacct aattagatta tgataaatag gtttgtcatt   3660

ttgcaagtta cataaacatt tatcaatgaa gtcatccttt agacttgtaa tcgccacatt   3720

gtttcattat tcagtttcct ctgtaaaggg atcttgagtt gttttaattt tttttttctg   3780

catctgaatc tgcatgattt ccaaaccctg taccatctga attttgcatt ttagcacttg   3840

cactattact cagcagcagt aacatggtaa cacttaaaat ggtactcggg gacctccaaa   3900

gactaaactg acaagccttc aaggagccca ggggtaagtt aacttgtcaa cggcatggtt   3960

taatcccttc tttacacttg tgtaaatttc agttactggt catagaaggc tttcaatgtt   4020

gagtggcctt ttattaacat gtttatggta ctgcatagat acgggtattt attttaccct   4080

aagaagattt tgaagtttaa aagtacttaa actatttggc aaagatttgt ttttaaaaat   4140

ctatttggtc aatctaaatg cattcattct aaaaaatttt ttgaaccaga taaataaaat   4200

ttttttttga caccacaaaa aaaaaaaaaa aaaaaa                             4236


<210>  5
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
1               5                   10                  15


Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            20                  25                  30


Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        35                  40                  45


Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    50                  55                  60


Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Asp 
65                  70                  75                  80


Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser Ala Val Lys Val 
                85                  90                  95


Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val Leu Gly Leu Pro 
            100                 105                 110


Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly 
        115                 120                 125


Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys Thr Gly His Ser 
    130                 135                 140


Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu Thr Gln Val Lys 
145                 150                 155                 160


Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp Cys Asp Cys Lys 
                165                 170                 175


Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu Arg Ser Arg Lys 
            180                 185                 190


Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp Glu Leu Arg 
        195                 200                 205


Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe Ile Pro Lys 
    210                 215                 220


Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp Gln Ile Ala 
225                 230                 235                 240


Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile Ser Val His 
                245                 250                 255


Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln Leu Glu Arg 
            260                 265                 270


Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly 
        275                 280                 285


Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly 
    290                 295                 300


Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro 
305                 310                 315                 320


Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met 
                325                 330                 335


Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn 
            340                 345                 350


Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly 
        355                 360                 365


Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly 
    370                 375                 380


Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly 
385                 390                 395                 400


Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
                405                 410


<210>  6
<211>  2460
<212>  DNA
<213>  Homo sapiens

<400>  6
ggccagctgg acgggcacac catgaggctg ctgaccctcc tgggccttct gtgtggctcg     60

gtggccaccc ccttgggccc gaagtggcct gaacctgtgt tcgggcgcct ggcatccccc    120

ggctttccag gggagtatgc caatgaccag gagcggcgct ggaccctgac tgcacccccc    180

ggctaccgcc tgcgcctcta cttcacccac ttcgacctgg agctctccca cctctgcgag    240

tacgacttcg tcaagctgag ctcgggggcc aaggtgctgg ccacgctgtg cgggcaggag    300

agcacagaca cggagcgggc ccctggcaag gacactttct actcgctggg ctccagcctg    360

gacattacct tccgctccga ctactccaac gagaagccgt tcacggggtt cgaggccttc    420

tatgcagccg aggacattga cgagtgccag gtggccccgg gagaggcgcc cacctgcgac    480

caccactgcc acaaccacct gggcggtttc tactgctcct gccgcgcagg ctacgtcctg    540

caccgtaaca agcgcacctg ctcagccctg tgctccggcc aggtcttcac ccagaggtct    600

ggggagctca gcagccctga atacccacgg ccgtatccca aactctccag ttgcacttac    660

agcatcagcc tggaggaggg gttcagtgtc attctggact ttgtggagtc cttcgatgtg    720

gagacacacc ctgaaaccct gtgtccctac gactttctca agattcaaac agacagagaa    780

gaacatggcc cattctgtgg gaagacattg ccccacagga ttgaaacaaa aagcaacacg    840

gtgaccatca cctttgtcac agatgaatca ggagaccaca caggctggaa gatccactac    900

acgagcacag cgcagccttg cccttatccg atggcgccac ctaatggcca cgtttcacct    960

gtgcaagcca aatacatcct gaaagacagc ttctccatct tttgcgagac tggctatgag   1020

cttctgcaag gtcacttgcc cctgaaatcc tttactgcag tttgtcagaa agatggatct   1080

tgggaccggc caatgcccgc gtgcagcatt gttgactgtg gccctcctga tgatctaccc   1140

agtggccgag tggagtacat cacaggtcct ggagtgacca cctacaaagc tgtgattcag   1200

tacagctgtg aagagacctt ctacacaatg aaagtgaatg atggtaaata tgtgtgtgag   1260

gctgatggat tctggacgag ctccaaagga gaaaaatcac tcccagtctg tgagcctgtt   1320

tgtggactat cagcccgcac aacaggaggg cgtatatatg gagggcaaaa ggcaaaacct   1380

ggtgattttc cttggcaagt cctgatatta ggtggaacca cagcagcagg tgcactttta   1440

tatgacaact gggtcctaac agctgctcat gccgtctatg agcaaaaaca tgatgcatcc   1500

gccctggaca ttcgaatggg caccctgaaa agactatcac ctcattatac acaagcctgg   1560

tctgaagctg tttttataca tgaaggttat actcatgatg ctggctttga caatgacata   1620

gcactgatta aattgaataa caaagttgta atcaatagca acatcacgcc tatttgtctg   1680

ccaagaaaag aagctgaatc ctttatgagg acagatgaca ttggaactgc atctggatgg   1740

ggattaaccc aaaggggttt tcttgctaga aatctaatgt atgtcgacat accgattgtt   1800

gaccatcaaa aatgtactgc tgcatatgaa aagccaccct atccaagggg aagtgtaact   1860

gctaacatgc tttgtgctgg cttagaaagt gggggcaagg acagctgcag aggtgacagc   1920

ggaggggcac tggtgtttct agatagtgaa acagagaggt ggtttgtggg aggaatagtg   1980

tcctggggtt ccatgaattg tggggaagca ggtcagtatg gagtctacac aaaagttatt   2040

aactatattc cctggatcga gaacataatt agtgattttt aacttgcgtg tctgcagtca   2100

aggattcttc atttttagaa atgcctgtga agaccttggc agcgacgtgg ctcgagaagc   2160

attcatcatt actgtggaca tggcagttgt tgctccaccc aaaaaaacag actccaggtg   2220

aggctgctgt catttctcca cttgccagtt taattccagc cttacccatt gactcaaggg   2280

gacataaacc acgagagtga cagtcatctt tgcccaccca gtgtaatgtc actgctcaaa   2340

ttacatttca ttaccttaaa aagccagtct cttttcatac tggctgttgg catttctgta   2400

aactgcctgt ccatgctctt tgtttttaaa cttgttctta ttgaaaaaaa aaaaaaaaaa   2460


<210>  7
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Arg Leu Leu Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr 
1               5                   10                  15


Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser 
            20                  25                  30


Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr 
        35                  40                  45


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60


Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80


Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95


Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser 
            100                 105                 110


Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln Val 
    130                 135                 140


Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His Leu 
145                 150                 155                 160


Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg Asn 
                165                 170                 175


Lys Arg Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gln Arg 
            180                 185                 190


Ser Gly Glu Leu Ser Ser Pro Glu Tyr Pro Arg Pro Tyr Pro Lys Leu 
        195                 200                 205


Ser Ser Cys Thr Tyr Ser Ile Ser Leu Glu Glu Gly Phe Ser Val Ile 
    210                 215                 220


Leu Asp Phe Val Glu Ser Phe Asp Val Glu Thr His Pro Glu Thr Leu 
225                 230                 235                 240


Cys Pro Tyr Asp Phe Leu Lys Ile Gln Thr Asp Arg Glu Glu His Gly 
                245                 250                 255


Pro Phe Cys Gly Lys Thr Leu Pro His Arg Ile Glu Thr Lys Ser Asn 
            260                 265                 270


Thr Val Thr Ile Thr Phe Val Thr Asp Glu Ser Gly Asp His Thr Gly 
        275                 280                 285


Trp Lys Ile His Tyr Thr Ser Thr Ala Gln Pro Cys Pro Tyr Pro Met 
    290                 295                 300


Ala Pro Pro Asn Gly His Val Ser Pro Val Gln Ala Lys Tyr Ile Leu 
305                 310                 315                 320


Lys Asp Ser Phe Ser Ile Phe Cys Glu Thr Gly Tyr Glu Leu Leu Gln 
                325                 330                 335


Gly His Leu Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp Gly 
            340                 345                 350


Ser Trp Asp Arg Pro Met Pro Ala Cys Ser Ile Val Asp Cys Gly Pro 
        355                 360                 365


Pro Asp Asp Leu Pro Ser Gly Arg Val Glu Tyr Ile Thr Gly Pro Gly 
    370                 375                 380


Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu Thr Phe 
385                 390                 395                 400


Tyr Thr Met Lys Val Asn Asp Gly Lys Tyr Val Cys Glu Ala Asp Gly 
                405                 410                 415


Phe Trp Thr Ser Ser Lys Gly Glu Lys Ser Leu Pro Val Cys Glu Pro 
            420                 425                 430


Val Cys Gly Leu Ser Ala Arg Thr Thr Gly Gly Arg Ile Tyr Gly Gly 
        435                 440                 445


Gln Lys Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Ile Leu Gly 
    450                 455                 460


Gly Thr Thr Ala Ala Gly Ala Leu Leu Tyr Asp Asn Trp Val Leu Thr 
465                 470                 475                 480


Ala Ala His Ala Val Tyr Glu Gln Lys His Asp Ala Ser Ala Leu Asp 
                485                 490                 495


Ile Arg Met Gly Thr Leu Lys Arg Leu Ser Pro His Tyr Thr Gln Ala 
            500                 505                 510


Trp Ser Glu Ala Val Phe Ile His Glu Gly Tyr Thr His Asp Ala Gly 
        515                 520                 525


Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu Asn Asn Lys Val Val Ile 
    530                 535                 540


Asn Ser Asn Ile Thr Pro Ile Cys Leu Pro Arg Lys Glu Ala Glu Ser 
545                 550                 555                 560


Phe Met Arg Thr Asp Asp Ile Gly Thr Ala Ser Gly Trp Gly Leu Thr 
                565                 570                 575


Gln Arg Gly Phe Leu Ala Arg Asn Leu Met Tyr Val Asp Ile Pro Ile 
            580                 585                 590


Val Asp His Gln Lys Cys Thr Ala Ala Tyr Glu Lys Pro Pro Tyr Pro 
        595                 600                 605


Arg Gly Ser Val Thr Ala Asn Met Leu Cys Ala Gly Leu Glu Ser Gly 
    610                 615                 620


Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe Leu 
625                 630                 635                 640


Asp Ser Glu Thr Glu Arg Trp Phe Val Gly Gly Ile Val Ser Trp Gly 
                645                 650                 655


Ser Met Asn Cys Gly Glu Ala Gly Gln Tyr Gly Val Tyr Thr Lys Val 
            660                 665                 670


Ile Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile Ser Asp Phe 
        675                 680                 685


<210>  8
<211>  738
<212>  DNA
<213>  Homo sapiens

<400>  8
ggccagctgg acgggcacac catgaggctg ctgaccctcc tgggccttct gtgtggctcg     60

gtggccaccc ccttgggccc gaagtggcct gaacctgtgt tcgggcgcct ggcatccccc    120

ggctttccag gggagtatgc caatgaccag gagcggcgct ggaccctgac tgcacccccc    180

ggctaccgcc tgcgcctcta cttcacccac ttcgacctgg agctctccca cctctgcgag    240

tacgacttcg tcaagctgag ctcgggggcc aaggtgctgg ccacgctgtg cgggcaggag    300

agcacagaca cggagcgggc ccctggcaag gacactttct actcgctggg ctccagcctg    360

gacattacct tccgctccga ctactccaac gagaagccgt tcacggggtt cgaggccttc    420

tatgcagccg aggacattga cgagtgccag gtggccccgg gagaggcgcc cacctgcgac    480

caccactgcc acaaccacct gggcggtttc tactgctcct gccgcgcagg ctacgtcctg    540

caccgtaaca agcgcacctg ctcagagcag agcctctagc ctcccctgga gctccggcct    600

gcccagcagg tcagaagcca gagccagcct gctggcctca gctccgggtt gggctgagat    660

ggctgtgccc caactcccat tcacccacca tggacccaat aataaacctg gccccacccc    720

aaaaaaaaaa aaaaaaaa                                                  738


<210>  9
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Arg Leu Leu Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr 
1               5                   10                  15


Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser 
            20                  25                  30


Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr 
        35                  40                  45


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60


Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80


Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95


Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser 
            100                 105                 110


Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln Val 
    130                 135                 140


Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His Leu 
145                 150                 155                 160


Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg Asn 
                165                 170                 175


Lys Arg Thr Cys Ser Glu Gln Ser Leu 
            180                 185


<210>  10
<211>  1273
<212>  DNA
<213>  Homo sapiens

<400>  10
gcgggcggcg ggcggagctg gtcccgttgt gctgcggcgc cgcgcggcct gcagtcccgg     60

gcccgcgccc cgcgccgccc gcccgcccgc catggagccc ggccccgacg gccccgccgc    120

ctccggcccc gccgccatcc gcgagggctg gttccgcgag acctgcagcc tgtggcccgg    180

ccaggccctg tcactgcagg tggagcagct gctccaccac cggcgctcgc gctaccagga    240

catcctcgtc ttccgcagta agacctatgg caacgtgctg gtgttggacg gtgtcatcca    300

gtgcacggag agagacgagt tctcctacca ggagatgatc gccaacctgc ctctctgcag    360

ccaccccaac ccgcgaaagg tgctgatcat cgggggcgga gatggaggtg tcctgcggga    420

ggtggtgaag cacccctccg tggagtccgt ggtccagtgt gagatcgacg aggatgtcat    480

ccaagtctcc aagaagttcc tgccaggcat ggccattggc tactctagct cgaagctgac    540

cctacatgtg ggtgacggtt ttgagttcat gaaacagaat caggatgcct tcgacgtgat    600

catcactgac tcctcagacc ccatgggccc cgccgaaagt ctcttcaagg agtcctatta    660

ccagctcatg aagacagccc tcaaggaaga tggtgtcctc tgctgccagg gcgagtgcca    720

gtggctgcac ctggacctca tcaaggagat gcggcagttc tgccagtccc tgttccccgt    780

ggtggcctat gcctactgca ccatccccac ctaccccagc ggccagatcg gcttcatgct    840

gtgcagcaag aacccgagca cgaacttcca ggagccggtg cagccgctga cacagcagca    900

ggtggcgcag atgcagctga agtactacaa ctccgacgtg caccgcgccg cctttgtgct    960

gcccgagttt gcccgcaagg ccctgaatga tgtgagctga gcccaggcgc caccactgat   1020

gccacccagg acctcggacc ttggagcctg cggggtgcct cggcccctcc agccccgggc   1080

cggacctcct gctggctctc gcccaccaac caagtgttac aagccccaga atgctgcccg   1140

gcctgccctg ctgggcggac tgtctgtgtg tctgtctctc tggcgttcca cctccaagcc   1200

tataccagct gtgtacagcg ccatctctct gccttctgtt gcccctcact caccaaacac   1260

gtgtatttat agc                                                      1273


<210>  11
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Glu Pro Gly Pro Asp Gly Pro Ala Ala Ser Gly Pro Ala Ala Ile 
1               5                   10                  15


Arg Glu Gly Trp Phe Arg Glu Thr Cys Ser Leu Trp Pro Gly Gln Ala 
            20                  25                  30


Leu Ser Leu Gln Val Glu Gln Leu Leu His His Arg Arg Ser Arg Tyr 
        35                  40                  45


Gln Asp Ile Leu Val Phe Arg Ser Lys Thr Tyr Gly Asn Val Leu Val 
    50                  55                  60


Leu Asp Gly Val Ile Gln Cys Thr Glu Arg Asp Glu Phe Ser Tyr Gln 
65                  70                  75                  80


Glu Met Ile Ala Asn Leu Pro Leu Cys Ser His Pro Asn Pro Arg Lys 
                85                  90                  95


Val Leu Ile Ile Gly Gly Gly Asp Gly Gly Val Leu Arg Glu Val Val 
            100                 105                 110


Lys His Pro Ser Val Glu Ser Val Val Gln Cys Glu Ile Asp Glu Asp 
        115                 120                 125


Val Ile Gln Val Ser Lys Lys Phe Leu Pro Gly Met Ala Ile Gly Tyr 
    130                 135                 140


Ser Ser Ser Lys Leu Thr Leu His Val Gly Asp Gly Phe Glu Phe Met 
145                 150                 155                 160


Lys Gln Asn Gln Asp Ala Phe Asp Val Ile Ile Thr Asp Ser Ser Asp 
                165                 170                 175


Pro Met Gly Pro Ala Glu Ser Leu Phe Lys Glu Ser Tyr Tyr Gln Leu 
            180                 185                 190


Met Lys Thr Ala Leu Lys Glu Asp Gly Val Leu Cys Cys Gln Gly Glu 
        195                 200                 205


Cys Gln Trp Leu His Leu Asp Leu Ile Lys Glu Met Arg Gln Phe Cys 
    210                 215                 220


Gln Ser Leu Phe Pro Val Val Ala Tyr Ala Tyr Cys Thr Ile Pro Thr 
225                 230                 235                 240


Tyr Pro Ser Gly Gln Ile Gly Phe Met Leu Cys Ser Lys Asn Pro Ser 
                245                 250                 255


Thr Asn Phe Gln Glu Pro Val Gln Pro Leu Thr Gln Gln Gln Val Ala 
            260                 265                 270


Gln Met Gln Leu Lys Tyr Tyr Asn Ser Asp Val His Arg Ala Ala Phe 
        275                 280                 285


Val Leu Pro Glu Phe Ala Arg Lys Ala Leu Asn Asp Val Ser 
    290                 295                 300


<210>  12
<211>  1077
<212>  DNA
<213>  Homo sapiens

<400>  12
atccaagata gatcaactct ccctaaaggc tgacagtgaa ctcttggggc cgttttattc     60

tctgaggtta gcaaggagtc atctactagc cattcaggag gccagctggg aagacaaaat    120

aggcacccca aactcagcaa cttcataaca ccttcctctc cccgcctgaa gccttaaact    180

gcatcaagtc aaagaaacct ggggcaaatc cttaacatgt ttttgactgc agtaaatcca    240

cagccactct ctactccgag ctggcagatt gagaccaagt attcaacgaa agtgctcact    300

ggaaattgga tggaagagag gagaaagttc accagagaca ctgacaagac accccaatcc    360

atttacagaa aagaatacat ccccttccca gaccacagac cagaccagat ctccaggtgg    420

tatgggaaga ggaaagttga ggggctacct tacaaacacc tgatcaccca ccaccaggag    480

cccccacatc gctacctgat cagcacctat gacgaccatt acaaccggca tggttacaac    540

ccggggctgc ctccactccg cacttggaat ggacagaagt tgctgtggct gccagagaag    600

tctgactttc cccttcttgc tccccctaca aactatggac tctatgagca gctcaagcag    660

agacagctca cacccaaggc tggcctgaag cagagcactt atacttcatc ctaccccaga    720

ccaccgttgt gcgctatgtc ctggagggag catgcggtcc cggtccctcc ccatcgcctg    780

catcctctcc cacacttctg agagctgcca ccccaggagc agctcagata gaatcagctg    840

gagaccacag catcactgga cttgccagac aacaagtggc gcagataaac tcagagtacg    900

agatctggcc cgtcaaaggt gctctcagaa tcatcatctg catttggcgg tacctgtccc    960

ccctcaaaac ccacaggttc ctttcttttc catccaacaa ttaaagatct ttgacactaa   1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa      1077


<210>  13
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Phe Leu Thr Ala Val Asn Pro Gln Pro Leu Ser Thr Pro Ser Trp 
1               5                   10                  15


Gln Ile Glu Thr Lys Tyr Ser Thr Lys Val Leu Thr Gly Asn Trp Met 
            20                  25                  30


Glu Glu Arg Arg Lys Phe Thr Arg Asp Thr Asp Lys Thr Pro Gln Ser 
        35                  40                  45


Ile Tyr Arg Lys Glu Tyr Ile Pro Phe Pro Asp His Arg Pro Asp Gln 
    50                  55                  60


Ile Ser Arg Trp Tyr Gly Lys Arg Lys Val Glu Gly Leu Pro Tyr Lys 
65                  70                  75                  80


His Leu Ile Thr His His Gln Glu Pro Pro His Arg Tyr Leu Ile Ser 
                85                  90                  95


Thr Tyr Asp Asp His Tyr Asn Arg His Gly Tyr Asn Pro Gly Leu Pro 
            100                 105                 110


Pro Leu Arg Thr Trp Asn Gly Gln Lys Leu Leu Trp Leu Pro Glu Lys 
        115                 120                 125


Ser Asp Phe Pro Leu Leu Ala Pro Pro Thr Asn Tyr Gly Leu Tyr Glu 
    130                 135                 140


Gln Leu Lys Gln Arg Gln Leu Thr Pro Lys Ala Gly Leu Lys Gln Ser 
145                 150                 155                 160


Thr Tyr Thr Ser Ser Tyr Pro Arg Pro Pro Leu Cys Ala Met Ser Trp 
                165                 170                 175


Arg Glu His Ala Val Pro Val Pro Pro His Arg Leu His Pro Leu Pro 
            180                 185                 190


His Phe 



<210>  14
<211>  1606
<212>  DNA
<213>  Homo sapiens

<400>  14
acccacagca ctcattcctg aagctactgg ttggttccct gagaggtccc agaactctgc     60

gaagtgagtc cagcgctgag attttccttg cagatctatc aggatgagca tccaggcccc    120

acccagacta ctggagctgg cagggcagag cctgctgaga gaccaggcct tgtccatctc    180

tgccatggag gagctgccca gggtgctcta tctcccactc ttcatggagg ccttcagcag    240

gagacacttc cagactctga cggtgatggt tcaggcctgg cccttcacct gcctccctct    300

gggatcactg atgaagacgc ttcatttgga gaccttaaaa gcattgctgg aagggcttca    360

tatgctgctt acacagaagg atcgccccag gaggtggaaa cttcaagtgc tggatttgcg    420

ggatgttgac gagaatttct gggccagatg gcctggagcc tgggccctgt cctgcttccc    480

agagaccacg agtaagaggc agacagcaga ggactgtcca aggatgggag agcaccagcc    540

cttaaaggtg ttcatagaca tctgcctcaa ggaaataccc caggatgaat gcctgagata    600

cctcttccag tgggtttacc aaaggagagg tttagtacac ctgtgctgta gtaagctggt    660

caattatcta acgccgatta aatatctcag aaagtcattg aaaataatat acctgaatag    720

tattcaagag ctggaaattc gcaacatgtc ctggccacgt ctgataagaa agcttcgttg    780

ttacctgaag gagatgaaga atcttcgcaa actcgttttc tccaggtgcc atcattacac    840

gtcagataat gaactccaag gacggttagt tgccaaattc agctctgtgt tcctcaggct    900

ggaacacctt cagttgctta aaataaaatt gatcaccttc ttcagtgggc acctggaaca    960

gctgatcagg tgcctccaga accccttgga gaacttggaa ttaacttatg gctacctatt   1020

ggaagaagac atgaagtgtc tctcccagta cccaagcctc ggttacctaa agcatctgaa   1080

tctcagctac gtgctgctgt tccgcatcag tcttgaaccc ctcggagctc tgctggagaa   1140

aattgctgcc tctctcaaaa ccctcatctt ggagggctgt cagatccact actcccaact   1200

cagtgccatc ctgcctgccc tgagccggtg ctcccagctc accaccttct actttggcag   1260

aaattgcatg tctattgacg ccctgaagga cctgctgcgc cacaccagtg ggctgagcaa   1320

gttaagcctg gagacgtatc ctgcccctga ggagagtttg aattccttgg ttcgtgtcaa   1380

ttgggagatc ttcaccccac ttcgggctga gctgatgtgt acactgaggg aagtcaggca   1440

gcccaagagg atcttcattg gccccacccc ctgcccttcc tgtggctcat caccgtctga   1500

ggaactggag ctccatcttt gctgctaggg aaggcgtgcc cagtggggta gagaaatcca   1560

aagttctctt ccaggcactt ggacactaaa atctactatg tgggtg                  1606


<210>  15
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Ile Gln Ala Pro Pro Arg Leu Leu Glu Leu Ala Gly Gln Ser 
1               5                   10                  15


Leu Leu Arg Asp Gln Ala Leu Ser Ile Ser Ala Met Glu Glu Leu Pro 
            20                  25                  30


Arg Val Leu Tyr Leu Pro Leu Phe Met Glu Ala Phe Ser Arg Arg His 
        35                  40                  45


Phe Gln Thr Leu Thr Val Met Val Gln Ala Trp Pro Phe Thr Cys Leu 
    50                  55                  60


Pro Leu Gly Ser Leu Met Lys Thr Leu His Leu Glu Thr Leu Lys Ala 
65                  70                  75                  80


Leu Leu Glu Gly Leu His Met Leu Leu Thr Gln Lys Asp Arg Pro Arg 
                85                  90                  95


Arg Trp Lys Leu Gln Val Leu Asp Leu Arg Asp Val Asp Glu Asn Phe 
            100                 105                 110


Trp Ala Arg Trp Pro Gly Ala Trp Ala Leu Ser Cys Phe Pro Glu Thr 
        115                 120                 125


Thr Ser Lys Arg Gln Thr Ala Glu Asp Cys Pro Arg Met Gly Glu His 
    130                 135                 140


Gln Pro Leu Lys Val Phe Ile Asp Ile Cys Leu Lys Glu Ile Pro Gln 
145                 150                 155                 160


Asp Glu Cys Leu Arg Tyr Leu Phe Gln Trp Val Tyr Gln Arg Arg Gly 
                165                 170                 175


Leu Val His Leu Cys Cys Ser Lys Leu Val Asn Tyr Leu Thr Pro Ile 
            180                 185                 190


Lys Tyr Leu Arg Lys Ser Leu Lys Ile Ile Tyr Leu Asn Ser Ile Gln 
        195                 200                 205


Glu Leu Glu Ile Arg Asn Met Ser Trp Pro Arg Leu Ile Arg Lys Leu 
    210                 215                 220


Arg Cys Tyr Leu Lys Glu Met Lys Asn Leu Arg Lys Leu Val Phe Ser 
225                 230                 235                 240


Arg Cys His His Tyr Thr Ser Asp Asn Glu Leu Gln Gly Arg Leu Val 
                245                 250                 255


Ala Lys Phe Ser Ser Val Phe Leu Arg Leu Glu His Leu Gln Leu Leu 
            260                 265                 270


Lys Ile Lys Leu Ile Thr Phe Phe Ser Gly His Leu Glu Gln Leu Ile 
        275                 280                 285


Arg Cys Leu Gln Asn Pro Leu Glu Asn Leu Glu Leu Thr Tyr Gly Tyr 
    290                 295                 300


Leu Leu Glu Glu Asp Met Lys Cys Leu Ser Gln Tyr Pro Ser Leu Gly 
305                 310                 315                 320


Tyr Leu Lys His Leu Asn Leu Ser Tyr Val Leu Leu Phe Arg Ile Ser 
                325                 330                 335


Leu Glu Pro Leu Gly Ala Leu Leu Glu Lys Ile Ala Ala Ser Leu Lys 
            340                 345                 350


Thr Leu Ile Leu Glu Gly Cys Gln Ile His Tyr Ser Gln Leu Ser Ala 
        355                 360                 365


Ile Leu Pro Ala Leu Ser Arg Cys Ser Gln Leu Thr Thr Phe Tyr Phe 
    370                 375                 380


Gly Arg Asn Cys Met Ser Ile Asp Ala Leu Lys Asp Leu Leu Arg His 
385                 390                 395                 400


Thr Ser Gly Leu Ser Lys Leu Ser Leu Glu Thr Tyr Pro Ala Pro Glu 
                405                 410                 415


Glu Ser Leu Asn Ser Leu Val Arg Val Asn Trp Glu Ile Phe Thr Pro 
            420                 425                 430


Leu Arg Ala Glu Leu Met Cys Thr Leu Arg Glu Val Arg Gln Pro Lys 
        435                 440                 445


Arg Ile Phe Ile Gly Pro Thr Pro Cys Pro Ser Cys Gly Ser Ser Pro 
    450                 455                 460


Ser Glu Glu Leu Glu Leu His Leu Cys Cys 
465                 470


<210>  16
<211>  1873
<212>  DNA
<213>  Homo sapiens

<400>  16
atgcaggaga gacccaaagt cttcaagcct ggagttcctg cttggttctt cctgaggtct     60

gagcaccttc tagactacat ccagatctgt tttccctgca gattcatgaa gatgagcatc    120

cggattccac ccagactcct ggagcttgcg ggcggagcct gctgagggac caagccttgg    180

ccgtctccac cctggaggag ctgcccacgg aacttttccc cccactgttc atggaggcct    240

tcagcaggag acgctgtgag gccctgaagc tgatggtgca ggcctggccc ttccgccgcc    300

tccctctgag gcctctgata aagatgcctt gtctggaggc cttccaagct gtgctcgatg    360

ggcttgatgc actgcttacc caaggggttc gtcccaggag atggaaactt caagtgctgg    420

atttacagga tgtctgtgag aacttctgga tggtttggtc tgaagctatg gcccatgggt    480

gcttcctcaa tgccaagagg aacaaaacac cagtgcagga ctgtccaagg atgagagaac    540

ggcagccctt gactgtgttt gtagaacttt ggctcaagaa caggactctg gatgaatacc    600

tcacctgcct ccttctatgg gtcaagcaga ggagagattt actacacctg tgctgtaaga    660

agctgaaaat tttgggaatg cccttccgca atatcagaag catcctgaaa atggtgaacc    720

tagactgtat ccaggaggtg gaagtgaatt gcaagtggat actgcccatc ctgacacagt    780

ttaccccata cctgggccac ttgaggaatc ttcagaagct cgttctctcc cacatggatg    840

tctctcgcta cgtttcccca gagcagaaga aggagattgt tacccagttc accactcagt    900

tcctcaagct gcgctgcctc caaaagcttt atatgaactc tgtttctttc ctcgaaggcc    960

acctggacca gctgctcagc tgtctgaaga cctcgttaaa ggtcctcaca ataactaact   1020

gtgtgctttt ggaatcagac ttgaagcatc tctcccagtg cccgagtatc agtcaactaa   1080

agaccctgga cctgagtggc atcagactga ccaattacag tcttgtgcct ctccaaattc   1140

tcctagaaaa agttgcagcc acccttgagt acctggattt agatgactgt ggcatcatag   1200

actcccaagt caacgccatc ctgcctgccc tgagccgctg ctttgagctc aacaccttca   1260

gcttctgtgg aaatcccatc tgcatggcca ccctggagaa cctgctgagc cacacaatca   1320

tactcaaaaa cttatgcctg gagctgtatc ctgccccgca ggaaagttat ggtgctgatg   1380

gtactctctg ctggagcaga tttgctcaaa ttagggctga gctgatgaag aaagtgaggc   1440

acttaaggca ccccaagagg atcttgttct gtactgacaa ctgccctgac catggcgaca   1500

ggtcatttta tgacctggag gcagatcaat actgctgttg aatgcctgcc tatttggatg   1560

ggtatgtcaa acgctttctt ctggacactt ggaaactaaa acctaggtct taggtacatc   1620

ctaaagggag cacagaaccc atcgtttcac acatgggctc tgaaagtggg aaaggaaagc   1680

tgatcaagca ggggcaggac ttgggggaaa tgttgccatg gattcgatgg gactttggga   1740

acctgtatcc tgtagagtcg aaaatgggaa tctgaatgtc tagagtggaa ttcaggcttg   1800

agaatacatg agggagttac tcttgcatgg atggttgtaa agaaacaatc agaaataaag   1860

gaaaactgag cag                                                      1873


<210>  17
<211>  1108
<212>  DNA
<213>  Homo sapiens

<400>  17
ctgagctaca actacaacca gaggtctaaa ctacaaccag atctgaattc ttgttgggag     60

ccattttgtg aagagacgaa gactgagctg gtttggctgc atttctggcc tcgagccgca    120

gtcagtttct ccccgtagaa cccggcagta ggagacttag aatcgaatct cttctccctc    180

ccgcctcctg tttttggctt tttgagaaac cttatcatcc aacacaatgg ccagcaacgt    240

taccaacaag atggatcctc actccatgaa ctcccgtgtg ttcattggga atctcaacac    300

tcttgttgtc aagaaatcgg atgtggaggc gatcttttcc aagtatggca aaattgcggg    360

ctgctctgtt cataagggct ttgccttcgt tcaatatgat aaggagaaaa atgcccgggc    420

tgctgtagca ggagaggatg gcagaatgat tgctagccag gttgtagata ttaacctggc    480

tgcagagcca aaagtgaacc gaggaaacgc aggtgtgaaa cgatcagcag cggagatgta    540

cggctcctct tttgacttgg actatggctt tcaacgggat tattatgatg gaatgtacag    600

tttcccagca cgtgtacctc ctcctcctcc cattgctctg gctgtagtgc cctcgaaacg    660

tcaacgtcta tcaggaaaca cctcacgaag gggcaaaagt ggcttcaatt ctaagagtgg    720

aaagcgggga tcttccaagt ctggaaagtt gaaaggtgat gaccttcagg ccattaagca    780

ggagttgacc cagataaaac agaaagtgga ttctctcctg gaaaacctgg aaaaaattga    840

aaaggaacag agcaaacaag aggtagaggt gaaaaatgct aagtcagaag aggagcagag    900

cagtagctcc atgaagaaag atgagactca tgtgaagatg gagtctgagg ggggtgcaga    960

agactctgct gaggaggggg acccactgga tgatgatgtt aatgaagatc agggggatga   1020

ccagctggag ttgatcaagg atgatgaaaa agaggctgag gaaggagagg atgacagaga   1080

cagcaccaat ggccaggatg actcttaa                                      1108


<210>  18
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Ser Asn Val Thr Asn Lys Met Asp Pro His Ser Met Asn Ser 
1               5                   10                  15


Arg Val Phe Ile Gly Asn Leu Asn Thr Leu Val Val Lys Lys Ser Asp 
            20                  25                  30


Val Glu Ala Ile Phe Ser Lys Tyr Gly Lys Ile Ala Gly Cys Ser Val 
        35                  40                  45


His Lys Gly Phe Ala Phe Val Gln Tyr Asp Lys Glu Lys Asn Ala Arg 
    50                  55                  60


Ala Ala Val Ala Gly Glu Asp Gly Arg Met Ile Ala Ser Gln Val Val 
65                  70                  75                  80


Asp Ile Asn Leu Ala Ala Glu Pro Lys Val Asn Arg Gly Asn Ala Gly 
                85                  90                  95


Val Lys Arg Ser Ala Ala Glu Met Tyr Gly Ser Ser Phe Asp Leu Asp 
            100                 105                 110


Tyr Gly Phe Gln Arg Asp Tyr Tyr Asp Gly Met Tyr Ser Phe Pro Ala 
        115                 120                 125


Arg Val Pro Pro Pro Pro Pro Ile Ala Leu Ala Val Val Pro Ser Lys 
    130                 135                 140


Arg Gln Arg Leu Ser Gly Asn Thr Ser Arg Arg Gly Lys Ser Gly Phe 
145                 150                 155                 160


Asn Ser Lys Ser Gly Lys Arg Gly Ser Ser Lys Ser Gly Lys Leu Lys 
                165                 170                 175


Gly Asp Asp Leu Gln Ala Ile Lys Gln Glu Leu Thr Gln Ile Lys Gln 
            180                 185                 190


Lys Val Asp Ser Leu Leu Glu Asn Leu Glu Lys Ile Glu Lys Glu Gln 
        195                 200                 205


Ser Lys Gln Glu Val Glu Val Lys Asn Ala Lys Ser Glu Glu Glu Gln 
    210                 215                 220


Ser Ser Ser Ser Met Lys Lys Asp Glu Thr His Val Lys Met Glu Ser 
225                 230                 235                 240


Glu Gly Gly Ala Glu Asp Ser Ala Glu Glu Gly Asp Pro Leu Asp Asp 
                245                 250                 255


Asp Val Asn Glu Asp Gln Gly Asp Asp Gln Leu Glu Leu Ile Lys Asp 
            260                 265                 270


Asp Glu Lys Glu Ala Glu Glu Gly Glu Asp Asp Arg Asp Ser Thr Asn 
        275                 280                 285


Gly Gln Asp Asp Ser 
    290


<210>  19
<211>  1642
<212>  DNA
<213>  Homo sapiens

<400>  19
cctgaagcta ctggttggtt ccctgagagg tcccagaact ctgcaaagtg agtccagcgc     60

tgagattttt cttgcagatc catcaggatg agcatccagg ccccaccgag actactggag    120

ctggcggggc agagcctgct gagagaccag gccttgtcca tctctgccat ggaggagctg    180

cccagggtgc tctatctccc actcttcagg gaggccttca gcaggagaca cttccagact    240

ctgacggtga tggtgcaggc ctggcctttc acctgcctcc ctctggtatc gctgatgaag    300

acgcttcatc tggagccatt gaaagcattg ctggaagggc ttcatatgct gcttacacag    360

aaggatcgcc ccaggaggtg gaaacttcaa gtgctggatt tgcgggatgt tgatgagaat    420

ttctgggcca gatggcctgg agcctgggcc ctgtcctgct tcccagaggc catgagtaag    480

aggcagacag cagaggactg tccaaggacg ggagagcacc agcccttaaa ggtgttcata    540

gacatctgcc tcaaggaaat accccaggat gaatgcctga gatacctctt ccagtgggtt    600

taccaaagga gaggtttagt acacctgtgc tgtagtaagc tggtcaatta tctaacgcca    660

attaaatatc tcagaaagtc attgaaaata atatacatta atagtattgg ggagctggaa    720

attcacaaca cgtgctggcc acatctgata agaaagcttt attgttacct gaaggagatg    780

aagactcttt gcaaactcgt tttctccagg tgccatcatt acacgtcaga taatgaactc    840

gagggatggt tagtcaccag attcacctct gtgttcctca ggctggaaca cctccagttg    900

cttaaaataa aattgatcac cttcttcagt gggcacctgg aacagctgat caggtgcctc    960

cagaacccct tggagaactt ggaattaact tgtggcaacc tattagaaga ggacttgaag   1020

tgtctctccc agttcccaag cctcggttac ctaaagcatc tgaatctcag ctacgtgctg   1080

ctgttccgca tcagtcttga acccctagga gctctgctag agaaaattgc tgcctctctc   1140

gagaccctcg tgttagaggg ctgtcagatc cactactccc aactcagtgc catcctgcct   1200

ggcctgagct gctgctccca gctcaccacc ttctactttg gcagcaattg catgtctatt   1260

gacgccctga aggacctgct gcgccacacc agtgggctga gcaagttaag cctggagacg   1320

tatcctgccc ctgaggagag tttgaattcc ttggttcgtg tcaattggga gatcttcacc   1380

ccacttcggg ctgagctgat gtgtacactg agggaattca ggcagcccaa gaggatcttc   1440

attggcccca ccccctgccc ttcctgtggc tcatcaccgt ctgaggaact ggagctccat   1500

ctttgctgct agggaaggcg tgcccagtgg ggtagagaaa tccaaagttc tcttccaggc   1560

acttggacac taaaatctac tatgtaggtg caaactattt ttctcttttc ttatttattt   1620

cattttttaa taattccaaa at                                            1642


<210>  20
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ser Ile Gln Ala Pro Pro Arg Leu Leu Glu Leu Ala Gly Gln Ser 
1               5                   10                  15


Leu Leu Arg Asp Gln Ala Leu Ser Ile Ser Ala Met Glu Glu Leu Pro 
            20                  25                  30


Arg Val Leu Tyr Leu Pro Leu Phe Arg Glu Ala Phe Ser Arg Arg His 
        35                  40                  45


Phe Gln Thr Leu Thr Val Met Val Gln Ala Trp Pro Phe Thr Cys Leu 
    50                  55                  60


Pro Leu Val Ser Leu Met Lys Thr Leu His Leu Glu Pro Leu Lys Ala 
65                  70                  75                  80


Leu Leu Glu Gly Leu His Met Leu Leu Thr Gln Lys Asp Arg Pro Arg 
                85                  90                  95


Arg Trp Lys Leu Gln Val Leu Asp Leu Arg Asp Val Asp Glu Asn Phe 
            100                 105                 110


Trp Ala Arg Trp Pro Gly Ala Trp Ala Leu Ser Cys Phe Pro Glu Ala 
        115                 120                 125


Met Ser Lys Arg Gln Thr Ala Glu Asp Cys Pro Arg Thr Gly Glu His 
    130                 135                 140


Gln Pro Leu Lys Val Phe Ile Asp Ile Cys Leu Lys Glu Ile Pro Gln 
145                 150                 155                 160


Asp Glu Cys Leu Arg Tyr Leu Phe Gln Trp Val Tyr Gln Arg Arg Gly 
                165                 170                 175


Leu Val His Leu Cys Cys Ser Lys Leu Val Asn Tyr Leu Thr Pro Ile 
            180                 185                 190


Lys Tyr Leu Arg Lys Ser Leu Lys Ile Ile Tyr Ile Asn Ser Ile Gly 
        195                 200                 205


Glu Leu Glu Ile His Asn Thr Cys Trp Pro His Leu Ile Arg Lys Leu 
    210                 215                 220


Tyr Cys Tyr Leu Lys Glu Met Lys Thr Leu Cys Lys Leu Val Phe Ser 
225                 230                 235                 240


Arg Cys His His Tyr Thr Ser Asp Asn Glu Leu Glu Gly Trp Leu Val 
                245                 250                 255


Thr Arg Phe Thr Ser Val Phe Leu Arg Leu Glu His Leu Gln Leu Leu 
            260                 265                 270


Lys Ile Lys Leu Ile Thr Phe Phe Ser Gly His Leu Glu Gln Leu Ile 
        275                 280                 285


Arg Cys Leu Gln Asn Pro Leu Glu Asn Leu Glu Leu Thr Cys Gly Asn 
    290                 295                 300


Leu Leu Glu Glu Asp Leu Lys Cys Leu Ser Gln Phe Pro Ser Leu Gly 
305                 310                 315                 320


Tyr Leu Lys His Leu Asn Leu Ser Tyr Val Leu Leu Phe Arg Ile Ser 
                325                 330                 335


Leu Glu Pro Leu Gly Ala Leu Leu Glu Lys Ile Ala Ala Ser Leu Glu 
            340                 345                 350


Thr Leu Val Leu Glu Gly Cys Gln Ile His Tyr Ser Gln Leu Ser Ala 
        355                 360                 365


Ile Leu Pro Gly Leu Ser Cys Cys Ser Gln Leu Thr Thr Phe Tyr Phe 
    370                 375                 380


Gly Ser Asn Cys Met Ser Ile Asp Ala Leu Lys Asp Leu Leu Arg His 
385                 390                 395                 400


Thr Ser Gly Leu Ser Lys Leu Ser Leu Glu Thr Tyr Pro Ala Pro Glu 
                405                 410                 415


Glu Ser Leu Asn Ser Leu Val Arg Val Asn Trp Glu Ile Phe Thr Pro 
            420                 425                 430


Leu Arg Ala Glu Leu Met Cys Thr Leu Arg Glu Phe Arg Gln Pro Lys 
        435                 440                 445


Arg Ile Phe Ile Gly Pro Thr Pro Cys Pro Ser Cys Gly Ser Ser Pro 
    450                 455                 460


Ser Glu Glu Leu Glu Leu His Leu Cys Cys 
465                 470


<210>  21
<211>  1828
<212>  DNA
<213>  Homo sapiens

<400>  21
ttcctgcttg gttcttcctg agatctgagc accttctaga ctacatccag atctgttttc     60

cctgcagatt catgaagatg agcatctgga ctccacccag actcctggag cttgcagggc    120

ggagcctgct aagggaccaa gctttggcca tgtccaccct ggaggagctg cccacagaac    180

ttttcccccc actgttcatg gaggccttca gcaggagacg ctgtgaggcc ctgaagctga    240

tggtgcagtc ctggcccttc cgccgcctcc ctctgaggcc tctgataaag atgccttgtc    300

tggaggcctt ccaagctgtg ctcgatgggc tggatgcact gcttaaccta ggggttcgtc    360

ccaggaggtg gaaacttcaa gtgctggatt tacaggatgt ctgtgagaac ttctggatgg    420

tttggtctga agctatggcc catgggtgct tcctcaatgc caagaggaac aaaaaaccag    480

tggaggactg tccaaggatg agaggacggc agcccttgac tgtgttcgta gaactttggc    540

tcaagaacag gactctggat gaatacctca cctgcctcct tctatgggtc aagcagagga    600

aagatttact acacctgtgc tgtaagaagc tgaaaatttt gggaatgccc ttccgcaata    660

tcagaagcat cctgaaaatg gtgaacctag actgtatcca ggaggtggaa gtgaattgca    720

agtgggtact gcccatcctg acacagttta ccccatacct gggccacatg aggaatcttc    780

agaaactcat tctctcccac atggatgtct ctcgctacgt ttccccagag cagaagaagg    840

agattgttac ccagttcacc actcagttcc tcaagctgcg ctgcctccaa aagctttata    900

tgaactctgt ttctttcctc gaaggccacc tggaccagct gctcagctgt ctgaagacct    960

cgttaaagtt cctcacaata actaactgtg tgcttttgga atcagacttg aagcatctat   1020

cccagtgccc gagtatcagt caactaaaga ccctggacct gagtggcatc agactgacca   1080

attacagtct tgtgcctctc caaattctcc tagaaaaagt tgcagccacc cttgagtacc   1140

tggatttaga tgactgtggc atcatagact cccaagtcaa cgccatcttg cctgccctga   1200

gccgctgctt tgagctcaac accttcagct tctgtggaaa tcccatctgc atggccaccc   1260

tggagaacct gctgagccac acaatcatac tcaaaaactt atgcgtggag ctgtatcctg   1320

ccccccggga gagttatggt gctgatggta ctctctgctg gagcagattt gctcaaatta   1380

gggctgagct gatgaacaga gtgagggact taaggcaccc caagaggatc ttgttctgta   1440

ctgactactg ccctgactgt ggcaacaggt cattttatga cctggaggca gatcaatact   1500

gctgttgaat gcctgcctat ttggatgggt atgtcaaacg ctttcttctg gacacttgga   1560

aactaaaacc taggtcttag gtacatccta aagggagcac agaacccatc atttcacaca   1620

taggctctga aagtgggaaa ggaaagctga tcaagcaggg gccggacttg ggggaaatgt   1680

tgccatggat tcgatgggac tttggggacc tgtgtcctgt agagtcgaaa atgggaatct   1740

gaatgtctag agtggaattc aggcttgaga atacatgagg gagttactct tgcatggatg   1800

gttgtaaaga aacaatcaga aataaagg                                      1828


<210>  22
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Lys Met Ser Ile Trp Thr Pro Pro Arg Leu Leu Glu Leu Ala Gly 
1               5                   10                  15


Arg Ser Leu Leu Arg Asp Gln Ala Leu Ala Met Ser Thr Leu Glu Glu 
            20                  25                  30


Leu Pro Thr Glu Leu Phe Pro Pro Leu Phe Met Glu Ala Phe Ser Arg 
        35                  40                  45


Arg Arg Cys Glu Ala Leu Lys Leu Met Val Gln Ser Trp Pro Phe Arg 
    50                  55                  60


Arg Leu Pro Leu Arg Pro Leu Ile Lys Met Pro Cys Leu Glu Ala Phe 
65                  70                  75                  80


Gln Ala Val Leu Asp Gly Leu Asp Ala Leu Leu Asn Leu Gly Val Arg 
                85                  90                  95


Pro Arg Arg Trp Lys Leu Gln Val Leu Asp Leu Gln Asp Val Cys Glu 
            100                 105                 110


Asn Phe Trp Met Val Trp Ser Glu Ala Met Ala His Gly Cys Phe Leu 
        115                 120                 125


Asn Ala Lys Arg Asn Lys Lys Pro Val Glu Asp Cys Pro Arg Met Arg 
    130                 135                 140


Gly Arg Gln Pro Leu Thr Val Phe Val Glu Leu Trp Leu Lys Asn Arg 
145                 150                 155                 160


Thr Leu Asp Glu Tyr Leu Thr Cys Leu Leu Leu Trp Val Lys Gln Arg 
                165                 170                 175


Lys Asp Leu Leu His Leu Cys Cys Lys Lys Leu Lys Ile Leu Gly Met 
            180                 185                 190


Pro Phe Arg Asn Ile Arg Ser Ile Leu Lys Met Val Asn Leu Asp Cys 
        195                 200                 205


Ile Gln Glu Val Glu Val Asn Cys Lys Trp Val Leu Pro Ile Leu Thr 
    210                 215                 220


Gln Phe Thr Pro Tyr Leu Gly His Met Arg Asn Leu Gln Lys Leu Ile 
225                 230                 235                 240


Leu Ser His Met Asp Val Ser Arg Tyr Val Ser Pro Glu Gln Lys Lys 
                245                 250                 255


Glu Ile Val Thr Gln Phe Thr Thr Gln Phe Leu Lys Leu Arg Cys Leu 
            260                 265                 270


Gln Lys Leu Tyr Met Asn Ser Val Ser Phe Leu Glu Gly His Leu Asp 
        275                 280                 285


Gln Leu Leu Ser Cys Leu Lys Thr Ser Leu Lys Phe Leu Thr Ile Thr 
    290                 295                 300


Asn Cys Val Leu Leu Glu Ser Asp Leu Lys His Leu Ser Gln Cys Pro 
305                 310                 315                 320


Ser Ile Ser Gln Leu Lys Thr Leu Asp Leu Ser Gly Ile Arg Leu Thr 
                325                 330                 335


Asn Tyr Ser Leu Val Pro Leu Gln Ile Leu Leu Glu Lys Val Ala Ala 
            340                 345                 350


Thr Leu Glu Tyr Leu Asp Leu Asp Asp Cys Gly Ile Ile Asp Ser Gln 
        355                 360                 365


Val Asn Ala Ile Leu Pro Ala Leu Ser Arg Cys Phe Glu Leu Asn Thr 
    370                 375                 380


Phe Ser Phe Cys Gly Asn Pro Ile Cys Met Ala Thr Leu Glu Asn Leu 
385                 390                 395                 400


Leu Ser His Thr Ile Ile Leu Lys Asn Leu Cys Val Glu Leu Tyr Pro 
                405                 410                 415


Ala Pro Arg Glu Ser Tyr Gly Ala Asp Gly Thr Leu Cys Trp Ser Arg 
            420                 425                 430


Phe Ala Gln Ile Arg Ala Glu Leu Met Asn Arg Val Arg Asp Leu Arg 
        435                 440                 445


His Pro Lys Arg Ile Leu Phe Cys Thr Asp Tyr Cys Pro Asp Cys Gly 
    450                 455                 460


Asn Arg Ser Phe Tyr Asp Leu Glu Ala Asp Gln Tyr Cys Cys 
465                 470                 475


<210>  23
<211>  1518
<212>  DNA
<213>  Homo sapiens

<400>  23
ttcgcccttc ctgaggtctg agcaccctcc aaactgagtc cagatctgag tttttcctcg     60

gagatttgtc agaatgagcc tccaggcccc atccagactg ctggagctgg cagggcagag    120

cctgctgagg aaccagttct tgaccatctt caccctggat gagctgccca gggaggtctt    180

ccctctgatg ttcatggagg ccttcagcat gagacgtttt gaggccctga agctgatggt    240

gcaggcctgg cccttcctca gcctccctct gggatccctg atgaagacac ttcatctgga    300

gaccttgcaa gctgtcctga ggggacttga tacactggtg gcccagaagg ttcgccccag    360

gaggtggaaa cttcaagtgc tggatttgcg ggatgttgat gagaatttct ggaccatatg    420

gtctggagcc agggtcctct cctgctcccc agaggccatg agtaagaggc agacagtgga    480

ggactgtcca aggatgggag agcaccagcc cttgaaggtg ttcatagacc tctgcctaaa    540

ggaaagtaca ctggatgaat gcctgagcta cctttttggg tggatccact acagaagagg    600

cctagtgcac ctgtgttgta gtaaggtgca gaattactca atgcccactt caagtttcag    660

aaatctattg gaaaggatat acccagacag tatccaggag ttggaagtct ggaaaaagtg    720

ctctctcaat aaaacgggaa agtttgcccc ttacctgagc cagatgagca atcttcgtga    780

actcttttta gccttcggtt atgagcgtga gttgtacgtg agcgtccagt ggccgtgcat    840

tcctgacttg gactctccat tcctctgcct gtactacccc cagatgcttt atataaaaaa    900

gatcagtaat atcaaagagc acctggagca cctgctcagg tacctcaaga accccttggg    960

ggcctttata ttcagtgatg cttacctagc tgatcgggac atggagtgtc tgtctcagta   1020

cccaagcctc agtcagctaa aggagctgcg tctgattcat atcctaatgt ggaccaccca   1080

tcttgagccc cttggagttc tgctggagaa agttgctgct actctcaaga ccctcgtctt   1140

aaaggactgt cggatccagg acccccaact cagggtcctc ctgcctgccc tgagccactg   1200

ttcccagctc accaccttca actttcatgg aaatgagacc tccatgaatg ctctgaaaga   1260

cctgctgcgt cacacacgtg ggctgagcaa gttaggcctg gagttgtatc ctgcccctct   1320

ggagagtctt gactacaagg gtcatgtcaa ttgggagatc ctcaccccaa ttcgggctga   1380

gctgatgcgt acactcaggg aagtcaggca gcccaagagg atcttctttg gtcccgtccc   1440

ttgccctaac tgtggctcat ggccatctga gaaagtggac ttccatcttt gctcctaggg   1500

aaggcctggt tcgtggga                                                 1518


<210>  24
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ser Leu Gln Ala Pro Ser Arg Leu Leu Glu Leu Ala Gly Gln Ser 
1               5                   10                  15


Leu Leu Arg Asn Gln Phe Leu Thr Ile Phe Thr Leu Asp Glu Leu Pro 
            20                  25                  30


Arg Glu Val Phe Pro Leu Met Phe Met Glu Ala Phe Ser Met Arg Arg 
        35                  40                  45


Phe Glu Ala Leu Lys Leu Met Val Gln Ala Trp Pro Phe Leu Ser Leu 
    50                  55                  60


Pro Leu Gly Ser Leu Met Lys Thr Leu His Leu Glu Thr Leu Gln Ala 
65                  70                  75                  80


Val Leu Arg Gly Leu Asp Thr Leu Val Ala Gln Lys Val Arg Pro Arg 
                85                  90                  95


Arg Trp Lys Leu Gln Val Leu Asp Leu Arg Asp Val Asp Glu Asn Phe 
            100                 105                 110


Trp Thr Ile Trp Ser Gly Ala Arg Val Leu Ser Cys Ser Pro Glu Ala 
        115                 120                 125


Met Ser Lys Arg Gln Thr Val Glu Asp Cys Pro Arg Met Gly Glu His 
    130                 135                 140


Gln Pro Leu Lys Val Phe Ile Asp Leu Cys Leu Lys Glu Ser Thr Leu 
145                 150                 155                 160


Asp Glu Cys Leu Ser Tyr Leu Phe Gly Trp Ile His Tyr Arg Arg Gly 
                165                 170                 175


Leu Val His Leu Cys Cys Ser Lys Val Gln Asn Tyr Ser Met Pro Thr 
            180                 185                 190


Ser Ser Phe Arg Asn Leu Leu Glu Arg Ile Tyr Pro Asp Ser Ile Gln 
        195                 200                 205


Glu Leu Glu Val Trp Lys Lys Cys Ser Leu Asn Lys Thr Gly Lys Phe 
    210                 215                 220


Ala Pro Tyr Leu Ser Gln Met Ser Asn Leu Arg Glu Leu Phe Leu Ala 
225                 230                 235                 240


Phe Gly Tyr Glu Arg Glu Leu Tyr Val Ser Val Gln Trp Pro Cys Ile 
                245                 250                 255


Pro Asp Leu Asp Ser Pro Phe Leu Cys Leu Tyr Tyr Pro Gln Met Leu 
            260                 265                 270


Tyr Ile Lys Lys Ile Ser Asn Ile Lys Glu His Leu Glu His Leu Leu 
        275                 280                 285


Arg Tyr Leu Lys Asn Pro Leu Gly Ala Phe Ile Phe Ser Asp Ala Tyr 
    290                 295                 300


Leu Ala Asp Arg Asp Met Glu Cys Leu Ser Gln Tyr Pro Ser Leu Ser 
305                 310                 315                 320


Gln Leu Lys Glu Leu Arg Leu Ile His Ile Leu Met Trp Thr Thr His 
                325                 330                 335


Leu Glu Pro Leu Gly Val Leu Leu Glu Lys Val Ala Ala Thr Leu Lys 
            340                 345                 350


Thr Leu Val Leu Lys Asp Cys Arg Ile Gln Asp Pro Gln Leu Arg Val 
        355                 360                 365


Leu Leu Pro Ala Leu Ser His Cys Ser Gln Leu Thr Thr Phe Asn Phe 
    370                 375                 380


His Gly Asn Glu Thr Ser Met Asn Ala Leu Lys Asp Leu Leu Arg His 
385                 390                 395                 400


Thr Arg Gly Leu Ser Lys Leu Gly Leu Glu Leu Tyr Pro Ala Pro Leu 
                405                 410                 415


Glu Ser Leu Asp Tyr Lys Gly His Val Asn Trp Glu Ile Leu Thr Pro 
            420                 425                 430


Ile Arg Ala Glu Leu Met Arg Thr Leu Arg Glu Val Arg Gln Pro Lys 
        435                 440                 445


Arg Ile Phe Phe Gly Pro Val Pro Cys Pro Asn Cys Gly Ser Trp Pro 
    450                 455                 460


Ser Glu Lys Val Asp Phe His Leu Cys Ser 
465                 470


<210>  25
<211>  1425
<212>  DNA
<213>  Homo sapiens

<400>  25
atgagcatca gggccccacc cagactcctg gagctggcaa ggcagaggct gctgagggac     60

caggccttgg ccatctccac catggaggag ctgcccaggg agctcttccc cacactgttc    120

atggaggcct tcagcaggag acgctgtgaa accctgaaaa caatggtgca ggcctggcct    180

ttcacccgcc tccctctagg gtccctgatg aagtcgcctc atctggagtc attaaaatct    240

gtgctggaag gggttgatgt gctgttgacc caagaggttc gccccaggca gtcaaaactt    300

caagtgctgg acttgaggaa tgtggatgag aacttctgcg acatattttc tggagctact    360

gcatccttcc cggaggctct gagtcagaag caaacagcag ataactgtcc agggacaggc    420

aggcagcagc cattcatggt gttcatagac ctttgtctca agaacaggac actagatgaa    480

tgcctcaccc acctcttaga gtggggcaag cagagaaaag gcttactgca tgtgtgttgc    540

aaggagctgc aggtttttgg aatgcccatc cacagtatca tagaggtcct gaacatggtg    600

gagcttgact gtatccagga ggtggaagtg tgctgcccct gggagctgtc cactcttgtg    660

aagtttgccc cttacctggg ccagatgagg aatctccgca aacttgttct cttcaacatc    720

cgtgcatctg cctgcattcc cccagacaac aaggggcagt tcattgcccg attcacctct    780

cagttcctca agctggacta tttccagaat ctgtctatgc actccgtctc tttcctcgaa    840

ggccacctgg accagctgct caggtgtctc caggcctcct tggagatggt cgttatgacc    900

gactgcctgc tgtcagagtc ggacttgaag catctctctt ggtgcccgag catccgtcaa    960

ttaaaggagc tggacctgag gggtgtcacg ctgacccatt tcagccctga gcccctcaca   1020

ggtctgctgg agcaagttgt ggccaccctg cagaccctgg acttagagga ctgtgggatc   1080

atggattccc aactcagcgc catcctgcct gtcctgagcc gctgctccca gctcagcacc   1140

ttcagcttct gtgggaacct catctccatg gctgcccttg agaacctgct gcgccacacc   1200

gtcgggctga gcaagctaag cctggagctg tatcctgccc ctctggagag ttatgacacc   1260

cagggtgctc tctgctgggg gagatttgct gaacttgggg ctgagctgat gaagacaccg   1320

agggacttaa ggcagcccaa gatcattgtg ttctgcaccg tcccctgccc tcgctgtggc   1380

atcagggcct cctatgacct ggagcccagt cactgcctct gttga                   1425


<210>  26
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ser Ile Arg Ala Pro Pro Arg Leu Leu Glu Leu Ala Arg Gln Arg 
1               5                   10                  15


Leu Leu Arg Asp Gln Ala Leu Ala Ile Ser Thr Met Glu Glu Leu Pro 
            20                  25                  30


Arg Glu Leu Phe Pro Thr Leu Phe Met Glu Ala Phe Ser Arg Arg Arg 
        35                  40                  45


Cys Glu Thr Leu Lys Thr Met Val Gln Ala Trp Pro Phe Thr Arg Leu 
    50                  55                  60


Pro Leu Gly Ser Leu Met Lys Ser Pro His Leu Glu Ser Leu Lys Ser 
65                  70                  75                  80


Val Leu Glu Gly Val Asp Val Leu Leu Thr Gln Glu Val Arg Pro Arg 
                85                  90                  95


Gln Ser Lys Leu Gln Val Leu Asp Leu Arg Asn Val Asp Glu Asn Phe 
            100                 105                 110


Cys Asp Ile Phe Ser Gly Ala Thr Ala Ser Phe Pro Glu Ala Leu Ser 
        115                 120                 125


Gln Lys Gln Thr Ala Asp Asn Cys Pro Gly Thr Gly Arg Gln Gln Pro 
    130                 135                 140


Phe Met Val Phe Ile Asp Leu Cys Leu Lys Asn Arg Thr Leu Asp Glu 
145                 150                 155                 160


Cys Leu Thr His Leu Leu Glu Trp Gly Lys Gln Arg Lys Gly Leu Leu 
                165                 170                 175


His Val Cys Cys Lys Glu Leu Gln Val Phe Gly Met Pro Ile His Ser 
            180                 185                 190


Ile Ile Glu Val Leu Asn Met Val Glu Leu Asp Cys Ile Gln Glu Val 
        195                 200                 205


Glu Val Cys Cys Pro Trp Glu Leu Ser Thr Leu Val Lys Phe Ala Pro 
    210                 215                 220


Tyr Leu Gly Gln Met Arg Asn Leu Arg Lys Leu Val Leu Phe Asn Ile 
225                 230                 235                 240


Arg Ala Ser Ala Cys Ile Pro Pro Asp Asn Lys Gly Gln Phe Ile Ala 
                245                 250                 255


Arg Phe Thr Ser Gln Phe Leu Lys Leu Asp Tyr Phe Gln Asn Leu Ser 
            260                 265                 270


Met His Ser Val Ser Phe Leu Glu Gly His Leu Asp Gln Leu Leu Arg 
        275                 280                 285


Cys Leu Gln Ala Ser Leu Glu Met Val Val Met Thr Asp Cys Leu Leu 
    290                 295                 300


Ser Glu Ser Asp Leu Lys His Leu Ser Trp Cys Pro Ser Ile Arg Gln 
305                 310                 315                 320


Leu Lys Glu Leu Asp Leu Arg Gly Val Thr Leu Thr His Phe Ser Pro 
                325                 330                 335


Glu Pro Leu Thr Gly Leu Leu Glu Gln Val Val Ala Thr Leu Gln Thr 
            340                 345                 350


Leu Asp Leu Glu Asp Cys Gly Ile Met Asp Ser Gln Leu Ser Ala Ile 
        355                 360                 365


Leu Pro Val Leu Ser Arg Cys Ser Gln Leu Ser Thr Phe Ser Phe Cys 
    370                 375                 380


Gly Asn Leu Ile Ser Met Ala Ala Leu Glu Asn Leu Leu Arg His Thr 
385                 390                 395                 400


Val Gly Leu Ser Lys Leu Ser Leu Glu Leu Tyr Pro Ala Pro Leu Glu 
                405                 410                 415


Ser Tyr Asp Thr Gln Gly Ala Leu Cys Trp Gly Arg Phe Ala Glu Leu 
            420                 425                 430


Gly Ala Glu Leu Met Lys Thr Pro Arg Asp Leu Arg Gln Pro Lys Ile 
        435                 440                 445


Ile Val Phe Cys Thr Val Pro Cys Pro Arg Cys Gly Ile Arg Ala Ser 
    450                 455                 460


Tyr Asp Leu Glu Pro Ser His Cys Leu Cys 
465                 470


<210>  27
<211>  1298
<212>  DNA
<213>  Homo sapiens

<400>  27
atgggactca acttctacac accaccacca ccacttaatc gtgattcccc caaacagcag     60

agcctcagca gccagcagag gaggtggaaa cttcaagtgc tggacttgct ggatgttgat    120

gagaatgtct gggctggatg gcctggaggc taggccctgt cctcctcccc agaggccatg    180

agtaagaggc agacagcaga ggactatcca aggatgggag agcaccagcc cttaaaggtg    240

ttcatagacg tctgcctcaa ggaaacaccc caagatgaat gcctgagata cctcttccag    300

tgggtttacc aaaggagagt tttagtacac ctgtgctgta gtaagttggt gaattatcta    360

acacccatta aatatcttag aaagtcattg aaaatagtcc acctgaatag tattcaggag    420

ttggaaattc acaacatgtc ctggctgcat ctgataagaa agcttcattg ttacctgaag    480

gagatgaaga atcttcgcaa actcgttttc tccaggtgcc atcattactc gtcggacaat    540

gacctcgagg aatggttact caccaaattc agcctgtgtt cctcaggctg gaacacctcc    600

aattgcttaa agtaaaattg atcaccttct tcagtgggca cctggaacag ctgatcaggt    660

gcctccagaa ccccttggag aacttggagt taacttgtgg ctacctattg gaagaggaca    720

tgaagtgtct gtctcagtac ccaagcctca gctacctaaa gcatctgaat ctcagctacg    780

tgctgctgtt ccgcatcagt cttgaacccc tcggagctct gctagagaaa attgctgcca    840

ctctcaagac cctcatcttc gagggctgtc agatccacta ctgccaactc agcgccatcc    900

tgcctggcct gagccgctgc tcccagctca ccaccttcta ctttggcaga aattgcatgt    960

ctacggacac cctgaaggac ctgctgcgcc acaccagtgg gctgagcaag ttaagcctgg   1020

agacgtatcc tgcccctgag gagagtttga attccttggt tcgtgtcgat tgggagatct   1080

tcgccccact tcgggctgag ctgatgtgta cactgaggga agtcaggcag cccaagagga   1140

tcttcactgg tcccactccc tgcccttcct gtggctcatc accgtctgag gaactggagc   1200

tccatctttg ctgctaggga aggcgtgcct agtggggttg ataaatccaa agttctcttc   1260

caggcacttg gacactaaaa tctagtatgt aagtgcaa                           1298


<210>  28
<211>  1720
<212>  DNA
<213>  Homo sapiens

<400>  28
agcctggagt tcctgcttgg ttcttcctga ggactgagca ccttctagac tacatccaga     60

tctgttttcc ctgcagattc gtgaagatga gcatccggac tccacccaga ctcctggagc    120

ttgcagggcg gagcctgctg agggaccaag ccttggccat gtccaccctg gaggagctgc    180

ccacagaact tttcccccca ctgttcatgg aggccttcag caggagacgc tgtgaggccc    240

tgaagctgat ggtgcaggcc tggcccttcc gccgcctccc tctgaggcct ctgataaaga    300

tgccttgtct ggaggccttc caagctgtgc tcgatgggct ggatgcactg cttacccaag    360

gggttcatcc caggaggtgg aaacttcaag tgctggattt acaggatgtc tgtgagaact    420

tctggatggt ttggtctgaa gctatggccc gtgggtgctt cctcaatgcc aagaggaaca    480

aaacaccagt gcaggactgt ccaaggatga gaggacagca gcccttgact gtgttcgtag    540

aactttggct caagaacagg actctggatg aatacctcac ctgcctcctt ctatgggtca    600

agcagaggaa agatttacta cacctgtgct gtaagaagct gaaaattttg ggaatgccct    660

tccgcaatat cagaagcatc ctgaaaatgg tgaacctaga ctgtatccag gaggtggaag    720

tgaattgcaa gtgggtactg cccatcctga cacagtttac cccatacctg ggccacatga    780

ggaatcttca gaagctcgtt ctctcccaca tggatgtctc tcgctacgtt tccccagagc    840

agaagaagga gattgttacc cagttcacca ctcagttcct caagctgtgc tgcctccaaa    900

agctttctat gaactctgtt tctttcctcg aaggccacct ggaccagctg ctcagctgtc    960

tgaagacctc gttaaaggtc ctcacaataa ctaactgtgt gcttttggaa tcagacttga   1020

agcatctatc ccagtgcccg agtatcagtc aactaaagac cctggacctg agtggcatca   1080

gactgaccaa ttacagtctt gtgcctctcc aaattctcct agaaaaagtt gcagccaccc   1140

ttgagtacct ggatttagat gactgtggca tcatagactc ccaagtcaac gccatcctgc   1200

ctgccctgag ccgctgcttt gagctcaaca ccttcagctt ctgtggaaat cccatctcca   1260

tggccaccct ggagaacctg ctgagccaca caatcatact caaaaactta tgcgtggagc   1320

tgtatcctgc cccccgggag agttatgatg ctgatggtac tctctgctgg agcagatttg   1380

ctcaaattag ggctgagctg atgaagagag tgagggactt aaggcacccc aagaggatct   1440

tgttctgtac tgactgctgc cctgactgtg gcaacaggtc attttatgac ctggaggcag   1500

atcaatgctg ctgttgaatg cctgcctatt tgggtggata tgtcaaacgc tttcttctgg   1560

acacttggaa actaaaacct aggtcttagg tacatcctat agggagcaca gaacccatca   1620

tttcacacat gggctctgaa agtgggaaag ggaaggtgat caagcagggg caggacttgg   1680

gggaagtgtt gccatggatt cgatgggact ttggggacct                         1720


<210>  29
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ser Ile Arg Thr Pro Pro Arg Leu Leu Glu Leu Ala Gly Arg Ser 
1               5                   10                  15


Leu Leu Arg Asp Gln Ala Leu Ala Met Ser Thr Leu Glu Glu Leu Pro 
            20                  25                  30


Thr Glu Leu Phe Pro Pro Leu Phe Met Glu Ala Phe Ser Arg Arg Arg 
        35                  40                  45


Cys Glu Ala Leu Lys Leu Met Val Gln Ala Trp Pro Phe Arg Arg Leu 
    50                  55                  60


Pro Leu Arg Pro Leu Ile Lys Met Pro Cys Leu Glu Ala Phe Gln Ala 
65                  70                  75                  80


Val Leu Asp Gly Leu Asp Ala Leu Leu Thr Gln Gly Val His Pro Arg 
                85                  90                  95


Arg Trp Lys Leu Gln Val Leu Asp Leu Gln Asp Val Cys Glu Asn Phe 
            100                 105                 110


Trp Met Val Trp Ser Glu Ala Met Ala Arg Gly Cys Phe Leu Asn Ala 
        115                 120                 125


Lys Arg Asn Lys Thr Pro Val Gln Asp Cys Pro Arg Met Arg Gly Gln 
    130                 135                 140


Gln Pro Leu Thr Val Phe Val Glu Leu Trp Leu Lys Asn Arg Thr Leu 
145                 150                 155                 160


Asp Glu Tyr Leu Thr Cys Leu Leu Leu Trp Val Lys Gln Arg Lys Asp 
                165                 170                 175


Leu Leu His Leu Cys Cys Lys Lys Leu Lys Ile Leu Gly Met Pro Phe 
            180                 185                 190


Arg Asn Ile Arg Ser Ile Leu Lys Met Val Asn Leu Asp Cys Ile Gln 
        195                 200                 205


Glu Val Glu Val Asn Cys Lys Trp Val Leu Pro Ile Leu Thr Gln Phe 
    210                 215                 220


Thr Pro Tyr Leu Gly His Met Arg Asn Leu Gln Lys Leu Val Leu Ser 
225                 230                 235                 240


His Met Asp Val Ser Arg Tyr Val Ser Pro Glu Gln Lys Lys Glu Ile 
                245                 250                 255


Val Thr Gln Phe Thr Thr Gln Phe Leu Lys Leu Cys Cys Leu Gln Lys 
            260                 265                 270


Leu Ser Met Asn Ser Val Ser Phe Leu Glu Gly His Leu Asp Gln Leu 
        275                 280                 285


Leu Ser Cys Leu Lys Thr Ser Leu Lys Val Leu Thr Ile Thr Asn Cys 
    290                 295                 300


Val Leu Leu Glu Ser Asp Leu Lys His Leu Ser Gln Cys Pro Ser Ile 
305                 310                 315                 320


Ser Gln Leu Lys Thr Leu Asp Leu Ser Gly Ile Arg Leu Thr Asn Tyr 
                325                 330                 335


Ser Leu Val Pro Leu Gln Ile Leu Leu Glu Lys Val Ala Ala Thr Leu 
            340                 345                 350


Glu Tyr Leu Asp Leu Asp Asp Cys Gly Ile Ile Asp Ser Gln Val Asn 
        355                 360                 365


Ala Ile Leu Pro Ala Leu Ser Arg Cys Phe Glu Leu Asn Thr Phe Ser 
    370                 375                 380


Phe Cys Gly Asn Pro Ile Ser Met Ala Thr Leu Glu Asn Leu Leu Ser 
385                 390                 395                 400


His Thr Ile Ile Leu Lys Asn Leu Cys Val Glu Leu Tyr Pro Ala Pro 
                405                 410                 415


Arg Glu Ser Tyr Asp Ala Asp Gly Thr Leu Cys Trp Ser Arg Phe Ala 
            420                 425                 430


Gln Ile Arg Ala Glu Leu Met Lys Arg Val Arg Asp Leu Arg His Pro 
        435                 440                 445


Lys Arg Ile Leu Phe Cys Thr Asp Cys Cys Pro Asp Cys Gly Asn Arg 
    450                 455                 460


Ser Phe Tyr Asp Leu Glu Ala Asp Gln Cys Cys Cys 
465                 470                 475


<210>  30
<211>  1884
<212>  DNA
<213>  Homo sapiens

<400>  30
atgtgtttca ggcacgtgct gactgagaga cccaaagtct tcaagcctag agttcctgct     60

tggttcttcc tgaggactga gcaccttcta gactacatcc agatctgttt tccctgcaga    120

ttcgtgaaga tgagcatccg gactccaccc agactcctgg agcttgcagg gcggagcctg    180

ctgagggacc aagccttggc catgtccacc ctggaggagc tgcccacaga acttttcccc    240

ccactgttca tggaggcctt cagcaggaga cgctgtgagg ccctgaagct gatggtgcag    300

gcctggccct tccgccgcct ccctctgagg cctctgataa agatgccttg tctggaggcc    360

ttccaagctg tgctcgatgg gctggatgca ctgcttaccc aaggggttca tcccaggagg    420

tggaaacttc aagtgctgga tttacaggat gtctgtgaga acttctggat ggtttggtct    480

gaagctatgg cccatgggtg cttcctcaat gccaagagga acaaaaaacc agtgcaggac    540

tgtccaagga tgagaggaca gcagcccttg actgtgttcg tagaactttg gctcaagaac    600

aggactctgg atgaatacct cacctgcctc cttctatggg tcaagcagag gaaagattta    660

ctacacctgt gctgtaagaa gctgaaaatt ttgggaatgc ccttccgcaa tatcagaagc    720

atcctgaaaa tggtgaacct agactgtatc caggaggtgg aagtgaattg caagtgggta    780

ctgcccatcc tgacacagtt taccccatac ctgggccaca tgaggaatct tcagaagctc    840

gttctctccc acatggatgt ctctcgctac gtttccccag agcagaagaa ggagattgtt    900

acccagttca ccactcagtt cctcaagctg tgctgcctcc aaaagctttc tatgaactct    960

gtttctttcc tcgaaggcca cctggaccag ctgctcagct gtctgaagac ctcgttaaag   1020

gtcctcacaa taactaactg tgtgcttttg gaatcagact tgaagcatct atcccagtgc   1080

ccgagtatca gtcaactaaa gaccctggac ctgagtggca tcagactgac caattacagt   1140

cttgtgcctc tccaaattct cctagaaaaa gttgcagcca cccttgagta cctggattta   1200

gatgactgtg gcatcataga ctcccaagtc aacgccatcc tgcctgccct gagctgctgc   1260

tttgagctca acaccttcag cttctgtgga aatcccatct ccatggccac cctggagaac   1320

ctgctgagcc acacaatcat actcaaaaac ttatgcgtgg agctgtatcc tgccccccgg   1380

gagagttatg atgctgatgg tactctctgc tggagcagat ttcctcaaat tagggctgag   1440

ctgatgaaga gagtgaggga cttaaggcac cccaagagga tcttgttctg tactgactgc   1500

tgccctgact gtggcaacag gtcattttat gacctggagg cagatcaatg ctgctgttga   1560

atgcctgcct atttgggtgg atatgtcaaa cgctttcttc tggacacttg gaaactaaaa   1620

cctaggtctt aggtacatcc tatagggagc acagaaccca tcatttcaca catgggctct   1680

gaaagtggga aaggaaaggt gatcaagcag gggcaggact tgggggaagt gttgccatgg   1740

attcgatggg actttgggga cctgtgtcct gtagagtgga aaatgggaat ttgaatgtct   1800

agagtggagg cttgagaata cttgagggag ttactcttgg atgcatggtt gtaaagaaac   1860

aatcagaaat aaaggaaaac tgag                                          1884


<210>  31
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Cys Phe Arg His Val Leu Thr Glu Arg Pro Lys Val Phe Lys Pro 
1               5                   10                  15


Arg Val Pro Ala Trp Phe Phe Leu Arg Thr Glu His Leu Leu Asp Tyr 
            20                  25                  30


Ile Gln Ile Cys Phe Pro Cys Arg Phe Val Lys Met Ser Ile Arg Thr 
        35                  40                  45


Pro Pro Arg Leu Leu Glu Leu Ala Gly Arg Ser Leu Leu Arg Asp Gln 
    50                  55                  60


Ala Leu Ala Met Ser Thr Leu Glu Glu Leu Pro Thr Glu Leu Phe Pro 
65                  70                  75                  80


Pro Leu Phe Met Glu Ala Phe Ser Arg Arg Arg Cys Glu Ala Leu Lys 
                85                  90                  95


Leu Met Val Gln Ala Trp Pro Phe Arg Arg Leu Pro Leu Arg Pro Leu 
            100                 105                 110


Ile Lys Met Pro Cys Leu Glu Ala Phe Gln Ala Val Leu Asp Gly Leu 
        115                 120                 125


Asp Ala Leu Leu Thr Gln Gly Val His Pro Arg Arg Trp Lys Leu Gln 
    130                 135                 140


Val Leu Asp Leu Gln Asp Val Cys Glu Asn Phe Trp Met Val Trp Ser 
145                 150                 155                 160


Glu Ala Met Ala His Gly Cys Phe Leu Asn Ala Lys Arg Asn Lys Lys 
                165                 170                 175


Pro Val Gln Asp Cys Pro Arg Met Arg Gly Gln Gln Pro Leu Thr Val 
            180                 185                 190


Phe Val Glu Leu Trp Leu Lys Asn Arg Thr Leu Asp Glu Tyr Leu Thr 
        195                 200                 205


Cys Leu Leu Leu Trp Val Lys Gln Arg Lys Asp Leu Leu His Leu Cys 
    210                 215                 220


Cys Lys Lys Leu Lys Ile Leu Gly Met Pro Phe Arg Asn Ile Arg Ser 
225                 230                 235                 240


Ile Leu Lys Met Val Asn Leu Asp Cys Ile Gln Glu Val Glu Val Asn 
                245                 250                 255


Cys Lys Trp Val Leu Pro Ile Leu Thr Gln Phe Thr Pro Tyr Leu Gly 
            260                 265                 270


His Met Arg Asn Leu Gln Lys Leu Val Leu Ser His Met Asp Val Ser 
        275                 280                 285


Arg Tyr Val Ser Pro Glu Gln Lys Lys Glu Ile Val Thr Gln Phe Thr 
    290                 295                 300


Thr Gln Phe Leu Lys Leu Cys Cys Leu Gln Lys Leu Ser Met Asn Ser 
305                 310                 315                 320


Val Ser Phe Leu Glu Gly His Leu Asp Gln Leu Leu Ser Cys Leu Lys 
                325                 330                 335


Thr Ser Leu Lys Val Leu Thr Ile Thr Asn Cys Val Leu Leu Glu Ser 
            340                 345                 350


Asp Leu Lys His Leu Ser Gln Cys Pro Ser Ile Ser Gln Leu Lys Thr 
        355                 360                 365


Leu Asp Leu Ser Gly Ile Arg Leu Thr Asn Tyr Ser Leu Val Pro Leu 
    370                 375                 380


Gln Ile Leu Leu Glu Lys Val Ala Ala Thr Leu Glu Tyr Leu Asp Leu 
385                 390                 395                 400


Asp Asp Cys Gly Ile Ile Asp Ser Gln Val Asn Ala Ile Leu Pro Ala 
                405                 410                 415


Leu Ser Cys Cys Phe Glu Leu Asn Thr Phe Ser Phe Cys Gly Asn Pro 
            420                 425                 430


Ile Ser Met Ala Thr Leu Glu Asn Leu Leu Ser His Thr Ile Ile Leu 
        435                 440                 445


Lys Asn Leu Cys Val Glu Leu Tyr Pro Ala Pro Arg Glu Ser Tyr Asp 
    450                 455                 460


Ala Asp Gly Thr Leu Cys Trp Ser Arg Phe Pro Gln Ile Arg Ala Glu 
465                 470                 475                 480


Leu Met Lys Arg Val Arg Asp Leu Arg His Pro Lys Arg Ile Leu Phe 
                485                 490                 495


Cys Thr Asp Cys Cys Pro Asp Cys Gly Asn Arg Ser Phe Tyr Asp Leu 
            500                 505                 510


Glu Ala Asp Gln Cys Cys Cys 
        515


<210>  32
<211>  1751
<212>  DNA
<213>  Homo sapiens

<400>  32
atgagcctac aggccccacg cagactcctg gagctggcag ggcagagcct gctgggggac     60

caggccttgg ccatctccat cttggatgag ctgcccaggg agctcttccc cccactgttc    120

gtggaggcct tcactagcag acgctgcgag gttctgaagg tgatggtgca ggcctggccc    180

ttcccctgcc tccctctggg gtccctgatg aagacgcctg atctggagat cttacattat    240

gtagtggatg ggattgattg cctgcttgcc caaaaggttc gccccaggag gcggaaactt    300

caagtgctgg aattgcggga tgttgatgag aatttttgga ccatatggtc tggagccagg    360

cccctgtcct gctccccaga ggccatgagt aagaggcaga cagtggagga ctgtccaagg    420

acaggagaga agcagccctt gaaggtgttc atggatgttt gcctcaagga aaaattcatg    480

gatgaagatc tgagcttctt ctctgggtgg gtccagcaca gaagaggttc agtacacctg    540

tgctgtacta aggtggtgaa ttattcaatg agcattctaa atttcagaaa catattggaa    600

acagtatacc cagacagtat ccaagtgttg gaaatttgga acatgtgctg gccgtgtatg    660

atagtagagt ttagccctta cctgagccag atgaggaatc ttcgcaaact cttcatctcc    720

gatggctgtc tttccccaga gcagaagaag gagattgtta cccagttcac cactcagttc    780

ctcaagctgc actgcctcca aaagctttat atgaactctg tttctttcct cgaaggccac    840

ctggaccagc tgctcagctg tctgaagacc tcgttaaagg tcctcacaat aactaactgt    900

gtgcttttgg aatcagactt gaagcatcta tcccagtgcc cgagtatcag tcaactaaag    960

accctggacc tgagtggcat cagactgacc aattacagtc ttgtgcctct ccaaattctc   1020

ctagaaaaag ttgcagccac ccttgagtac ctggatttag atgactgtgg catcatagac   1080

tcccaagtca acgccatcct gcctgccctg agccgctgct ttgagctcaa caccttcagc   1140

ttctgtggaa atcccatctc catggccacc ctggagaacc tgctgagcca cacaatcata   1200

ctcaaaaact tatgcctgga gctgtatcct gccccacggg agagttatgg tgctgatggt   1260

actctctgct ggagcagatt tactcagatt agggctgagc tgatgaagag agttagggac   1320

ttaaggcacc ccaagaggat cttgttcggt actgactact gccctgactg tggcaacagg   1380

tcattttatg acctggaggc agatcaatac tgctgttgaa tgcctgccta tttggatggg   1440

tatgtcaaac gctttcttct ggacacttgg aaactaaaac ctaggtctta ggtacatcct   1500

aaagggagca cagaacccat cgtttcacac atgggctctg aaagtgggaa aggaatgctg   1560

atcaagcagg ggcaggactt gggggaaatg ttgccatgga ttcgatggga ctttgggaac   1620

gtgtatcctg tagagtcgaa aatgggaatc tgaatgtcta gagtggaatt caggcttgag   1680

aatacatgag ggagttactc ttgcatggat ggttgtaaat aaacaatcag aaataaagga   1740

aaactgagca g                                                        1751


<210>  33
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ser Leu Gln Ala Pro Arg Arg Leu Leu Glu Leu Ala Gly Gln Ser 
1               5                   10                  15


Leu Leu Gly Asp Gln Ala Leu Ala Ile Ser Ile Leu Asp Glu Leu Pro 
            20                  25                  30


Arg Glu Leu Phe Pro Pro Leu Phe Val Glu Ala Phe Thr Ser Arg Arg 
        35                  40                  45


Cys Glu Val Leu Lys Val Met Val Gln Ala Trp Pro Phe Pro Cys Leu 
    50                  55                  60


Pro Leu Gly Ser Leu Met Lys Thr Pro Asp Leu Glu Ile Leu His Tyr 
65                  70                  75                  80


Val Val Asp Gly Ile Asp Cys Leu Leu Ala Gln Lys Val Arg Pro Arg 
                85                  90                  95


Arg Arg Lys Leu Gln Val Leu Glu Leu Arg Asp Val Asp Glu Asn Phe 
            100                 105                 110


Trp Thr Ile Trp Ser Gly Ala Arg Pro Leu Ser Cys Ser Pro Glu Ala 
        115                 120                 125


Met Ser Lys Arg Gln Thr Val Glu Asp Cys Pro Arg Thr Gly Glu Lys 
    130                 135                 140


Gln Pro Leu Lys Val Phe Met Asp Val Cys Leu Lys Glu Lys Phe Met 
145                 150                 155                 160


Asp Glu Asp Leu Ser Phe Phe Ser Gly Trp Val Gln His Arg Arg Gly 
                165                 170                 175


Ser Val His Leu Cys Cys Thr Lys Val Val Asn Tyr Ser Met Ser Ile 
            180                 185                 190


Leu Asn Phe Arg Asn Ile Leu Glu Thr Val Tyr Pro Asp Ser Ile Gln 
        195                 200                 205


Val Leu Glu Ile Trp Asn Met Cys Trp Pro Cys Met Ile Val Glu Phe 
    210                 215                 220


Ser Pro Tyr Leu Ser Gln Met Arg Asn Leu Arg Lys Leu Phe Ile Ser 
225                 230                 235                 240


Asp Gly Cys Leu Ser Pro Glu Gln Lys Lys Glu Ile Val Thr Gln Phe 
                245                 250                 255


Thr Thr Gln Phe Leu Lys Leu His Cys Leu Gln Lys Leu Tyr Met Asn 
            260                 265                 270


Ser Val Ser Phe Leu Glu Gly His Leu Asp Gln Leu Leu Ser Cys Leu 
        275                 280                 285


Lys Thr Ser Leu Lys Val Leu Thr Ile Thr Asn Cys Val Leu Leu Glu 
    290                 295                 300


Ser Asp Leu Lys His Leu Ser Gln Cys Pro Ser Ile Ser Gln Leu Lys 
305                 310                 315                 320


Thr Leu Asp Leu Ser Gly Ile Arg Leu Thr Asn Tyr Ser Leu Val Pro 
                325                 330                 335


Leu Gln Ile Leu Leu Glu Lys Val Ala Ala Thr Leu Glu Tyr Leu Asp 
            340                 345                 350


Leu Asp Asp Cys Gly Ile Ile Asp Ser Gln Val Asn Ala Ile Leu Pro 
        355                 360                 365


Ala Leu Ser Arg Cys Phe Glu Leu Asn Thr Phe Ser Phe Cys Gly Asn 
    370                 375                 380


Pro Ile Ser Met Ala Thr Leu Glu Asn Leu Leu Ser His Thr Ile Ile 
385                 390                 395                 400


Leu Lys Asn Leu Cys Leu Glu Leu Tyr Pro Ala Pro Arg Glu Ser Tyr 
                405                 410                 415


Gly Ala Asp Gly Thr Leu Cys Trp Ser Arg Phe Thr Gln Ile Arg Ala 
            420                 425                 430


Glu Leu Met Lys Arg Val Arg Asp Leu Arg His Pro Lys Arg Ile Leu 
        435                 440                 445


Phe Gly Thr Asp Tyr Cys Pro Asp Cys Gly Asn Arg Ser Phe Tyr Asp 
    450                 455                 460


Leu Glu Ala Asp Gln Tyr Cys Cys 
465                 470


<210>  34
<211>  753
<212>  DNA
<213>  Homo sapiens

<400>  34
atggccagca acgttaccaa caagatggat cctcactccg tgaactcccg tgtgttcatt     60

gggaatctca acactcttgt tgtcaagaaa tctgatgtgg aggcgatctt ttccaagtat    120

ggcaaaattg cgggctgctc tgttcataag ggctttgcct tcgttcaata tgataaggag    180

aaaaatgccc gggctgctgt agcaggagag gatggcagaa tgattgctag ccaggttgca    240

gttattaacc tggctgcaga gccaaaagtg aaccgaggaa acgcaggtgt gaaacgatcc    300

gcagcggaga tgtacggctc ctcttttgac ttggactatg gctttcaacg ggattattat    360

gatgggatgt acagtttccc agcacgtgta cctcctcctc ctcccattgc tctggccatt    420

aagcaggagt tgacccagat aaaacagaaa gtggattctc tcctggaaaa cctggaaaaa    480

attgaaaagg aacagagcaa acaagaggta gaggtgaaaa atgctaagtc agaagaggag    540

cagagcagta gctccatgaa gaaagatgag actcatgtaa agatggagtc tgaggggggt    600

gcagaagact ctgctgagga gggggaccca ctggatgatg atgataatga agatcagggg    660

gacaaccagc ttcatttgat caagaataat gaaaaagatg ctgaggaagg agaggataac    720

agagacagca ccaatggcca ggatgactct taa                                 753


<210>  35
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ala Ser Asn Val Thr Asn Lys Met Asp Pro His Ser Val Asn Ser 
1               5                   10                  15


Arg Val Phe Ile Gly Asn Leu Asn Thr Leu Val Val Lys Lys Ser Asp 
            20                  25                  30


Val Glu Ala Ile Phe Ser Lys Tyr Gly Lys Ile Ala Gly Cys Ser Val 
        35                  40                  45


His Lys Gly Phe Ala Phe Val Gln Tyr Asp Lys Glu Lys Asn Ala Arg 
    50                  55                  60


Ala Ala Val Ala Gly Glu Asp Gly Arg Met Ile Ala Ser Gln Val Ala 
65                  70                  75                  80


Val Ile Asn Leu Ala Ala Glu Pro Lys Val Asn Arg Gly Asn Ala Gly 
                85                  90                  95


Val Lys Arg Ser Ala Ala Glu Met Tyr Gly Ser Ser Phe Asp Leu Asp 
            100                 105                 110


Tyr Gly Phe Gln Arg Asp Tyr Tyr Asp Gly Met Tyr Ser Phe Pro Ala 
        115                 120                 125


Arg Val Pro Pro Pro Pro Pro Ile Ala Leu Ala Ile Lys Gln Glu Leu 
    130                 135                 140


Thr Gln Ile Lys Gln Lys Val Asp Ser Leu Leu Glu Asn Leu Glu Lys 
145                 150                 155                 160


Ile Glu Lys Glu Gln Ser Lys Gln Glu Val Glu Val Lys Asn Ala Lys 
                165                 170                 175


Ser Glu Glu Glu Gln Ser Ser Ser Ser Met Lys Lys Asp Glu Thr His 
            180                 185                 190


Val Lys Met Glu Ser Glu Gly Gly Ala Glu Asp Ser Ala Glu Glu Gly 
        195                 200                 205


Asp Pro Leu Asp Asp Asp Asp Asn Glu Asp Gln Gly Asp Asn Gln Leu 
    210                 215                 220


His Leu Ile Lys Asn Asn Glu Lys Asp Ala Glu Glu Gly Glu Asp Asn 
225                 230                 235                 240


Arg Asp Ser Thr Asn Gly Gln Asp Asp Ser 
                245                 250


<210>  36
<211>  1520
<212>  DNA
<213>  Homo sapiens

<400>  36
atgtcagaga cagggacaag aatctcacct ctattttccc acaggaggtg gaaacttcaa     60

gtgctggatt tacaggatgt ctgtgagaac ttctggatgg tttggtctga agctatggcc    120

cgtgggtgct tcctcaatgc caagaggaac aaaaaaccag tgcaggactg tccaaggatg    180

agaggacggc agcccttgac tgtgttcgta gaactttggc tcaagaacag gactctggat    240

gaacacctca cctgcctcct tctatgggtc aagcagagga aagatttact acacctgtgc    300

tgtaagaagc tgaaaatttt gggaatgccc ttccgcaata tcagaagcat cctgaaaatg    360

gtgaacctag actgtatcca ggaggtggaa gtgaattgca agtgggtact gcccatcctg    420

acacagttta ccccatacct gggccacatg aggaatcttc agaagctcgt tctctcccac    480

atggatgtct ctcgctacgt ttccccagag cagaagaagg agattgttac ccagttcacc    540

actcagttcc tcaagctgca ctgcctccaa aagctttata tgaactctgt ttctttcctc    600

gaaggccacc tggaccagct gctcagctgt ctgaagacct cgttaaaggt cctcacaata    660

actaactgtg tgcttttgga atcagacttg aagcatctat cccagtgccc gagtatcagt    720

caactaaaga ccctggacct gagtggcatc agactgacca attacagtct tgtgcctctc    780

caaattctcc tagaaaaagt tgcagccacc cttgagtacc tggatttaga tgactgtggc    840

atcatagact cccaagtcaa cgccatcctg cctgccctga gccgctgctt tgagctcaac    900

accttcagct tctgtggaaa tcccatctcc atggccaccc tggagaacct gctgagccac    960

acaatcatac tcaaaaactt atgcctggag ctgtatcctg ccccacggga gagttatggt   1020

gctgatggta ctctctgctg gagcagattt actcagatta gggctgagct gatgaagaga   1080

gttagggact taaggcaccc caagaggatc ttgttcggta ctgactactg ccctgactgt   1140

ggcaacaggt cattttatga cctggaggca gatcaatact gctgttgaat gcctgcctat   1200

ttggatgggt atgtcaaacg ctttcttctg gacacttgga aactaaaacc taggtcttag   1260

gtacatccta aagggagcac agaacccatc gtttcacaca tgggctctga aagtgggaaa   1320

ggaatgctga tcaagcaggg gcaggacttg ggggaaatgt tgccatggat tcgatgggac   1380

tttggggacc tgtatcctgt agagtcgaaa atgggaatct gaatgtctag agtggaattc   1440

aggcttgaga atacatgagg gagttactct tgcatggatg gttgtaaaga aacaatcaga   1500

aataaaggaa aactgagcag                                               1520


<210>  37
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ser Glu Thr Gly Thr Arg Ile Ser Pro Leu Phe Ser His Arg Arg 
1               5                   10                  15


Trp Lys Leu Gln Val Leu Asp Leu Gln Asp Val Cys Glu Asn Phe Trp 
            20                  25                  30


Met Val Trp Ser Glu Ala Met Ala Arg Gly Cys Phe Leu Asn Ala Lys 
        35                  40                  45


Arg Asn Lys Lys Pro Val Gln Asp Cys Pro Arg Met Arg Gly Arg Gln 
    50                  55                  60


Pro Leu Thr Val Phe Val Glu Leu Trp Leu Lys Asn Arg Thr Leu Asp 
65                  70                  75                  80


Glu His Leu Thr Cys Leu Leu Leu Trp Val Lys Gln Arg Lys Asp Leu 
                85                  90                  95


Leu His Leu Cys Cys Lys Lys Leu Lys Ile Leu Gly Met Pro Phe Arg 
            100                 105                 110


Asn Ile Arg Ser Ile Leu Lys Met Val Asn Leu Asp Cys Ile Gln Glu 
        115                 120                 125


Val Glu Val Asn Cys Lys Trp Val Leu Pro Ile Leu Thr Gln Phe Thr 
    130                 135                 140


Pro Tyr Leu Gly His Met Arg Asn Leu Gln Lys Leu Val Leu Ser His 
145                 150                 155                 160


Met Asp Val Ser Arg Tyr Val Ser Pro Glu Gln Lys Lys Glu Ile Val 
                165                 170                 175


Thr Gln Phe Thr Thr Gln Phe Leu Lys Leu His Cys Leu Gln Lys Leu 
            180                 185                 190


Tyr Met Asn Ser Val Ser Phe Leu Glu Gly His Leu Asp Gln Leu Leu 
        195                 200                 205


Ser Cys Leu Lys Thr Ser Leu Lys Val Leu Thr Ile Thr Asn Cys Val 
    210                 215                 220


Leu Leu Glu Ser Asp Leu Lys His Leu Ser Gln Cys Pro Ser Ile Ser 
225                 230                 235                 240


Gln Leu Lys Thr Leu Asp Leu Ser Gly Ile Arg Leu Thr Asn Tyr Ser 
                245                 250                 255


Leu Val Pro Leu Gln Ile Leu Leu Glu Lys Val Ala Ala Thr Leu Glu 
            260                 265                 270


Tyr Leu Asp Leu Asp Asp Cys Gly Ile Ile Asp Ser Gln Val Asn Ala 
        275                 280                 285


Ile Leu Pro Ala Leu Ser Arg Cys Phe Glu Leu Asn Thr Phe Ser Phe 
    290                 295                 300


Cys Gly Asn Pro Ile Ser Met Ala Thr Leu Glu Asn Leu Leu Ser His 
305                 310                 315                 320


Thr Ile Ile Leu Lys Asn Leu Cys Leu Glu Leu Tyr Pro Ala Pro Arg 
                325                 330                 335


Glu Ser Tyr Gly Ala Asp Gly Thr Leu Cys Trp Ser Arg Phe Thr Gln 
            340                 345                 350


Ile Arg Ala Glu Leu Met Lys Arg Val Arg Asp Leu Arg His Pro Lys 
        355                 360                 365


Arg Ile Leu Phe Gly Thr Asp Tyr Cys Pro Asp Cys Gly Asn Arg Ser 
    370                 375                 380


Phe Tyr Asp Leu Glu Ala Asp Gln Tyr Cys Cys 
385                 390                 395


<210>  38
<211>  2104
<212>  DNA
<213>  Homo sapiens

<400>  38
gatttgtttt cttgcagatt tatgaggatg agcctacagg ccccacgcag actcctggag     60

ctggcagggc agagcctgct gggggaccag gccttggcca tctccatctt ggatgagctg    120

cccagggagc tcttcccccc actgttcgtg gaggccttca ctagcagacg ctgcgaggtt    180

ctgaaggtga tggtgcaggc ctggcccttc ccctgcctcc ctctggggtc cctgatgaag    240

acgcctgatc tggagatctt acattatgta gtggatggga ttgattgcct gcttgcccaa    300

aaggttcgcc ccaggaggcg gaaacttcaa gtgctggaat tgcgggatgt tgatgagaat    360

ttttggacca tatggtctgg agccaggccc ctgtcctgct ccccagaggc catgagtaag    420

aggcagacag tggaggactg tccaaggaca ggagagaagc agcccttgaa ggtgttcatg    480

gatgtttgcc tcaaggaaaa attcatggat gaagatctga gcttcttctc tgggtgggtc    540

cagcacagaa gaggttcagt acacctgtgc tgtactaagg tggtgaatta ttcaatgagc    600

attctaaatt tcagaaacat attggaaaca gtatacccag acagtatcca agtgttggaa    660

atttggaaca tgtgctggcc gtgtatgata gtagagttta tccgttacct gagccagatg    720

aggaatcttc gcaaactctt catctccgat ggctgtcgtt acctgctaag ctctgacagc    780

caagaacagt tagttgctga attcagctct gtgctcctca ggctggagta cctccagatg    840

ctttatgtaa gaagggtctg cttcttcaga ggccacctgg accagctgat caggtgcctc    900

aggagcccat tggagacatt ggcattaact tatggcttcc tagaaaaagt ggacttgaaa    960

tgtctgcccc ggtacccaag tctcagtcaa ctgaagcagc tgaatctgag tcatggtgca   1020

ctgcgcttca tccgtcttga gcccctccga gctctgctag agaaagttgc tgccactctt   1080

cagaccctct tcttagtgga ctgtgggatt cgggactcca aactcagggt catcctgcct   1140

gccctgagct gctgctccaa cctcaccact ttctgttttc acggcaatga cacgtccatg   1200

gatggtctga aggacctgct gcgccacaca ggcaggctga gcaatttgag cctggaaaca   1260

tatcctgccc ctcgggagag tcttgatgac aggggtcgtg tcatttcgga gctcctcacc   1320

ccacttcagg ctgagctgat gcgtatactg agggaagtaa gggagcccaa aaggatcttc   1380

tttggtccgg tgtcctgccc ttgctgtggc acgtcgccca ctgagcaact ggagttcaat   1440

ttttgcttgt ggggaaggcc tgcctagtgg ggtggaggta taaaaagctt tttctccagg   1500

cacttggaaa ctaaaatctg ggacatagat gtcttttatt tttctttttc cttattttac   1560

aattttacag tttttattta aaaatttgag acagggtttc cctatgttgt ccaggctggt   1620

ctcaaactct tacgcttaag ggagccacct gcttggcctc ccaagattct gggattacag   1680

gcataagcag ctgtgccggg tctataggtg tattataaag ggagcagaga aacctctgtt   1740

tcaggcatgt gctttctgtg agtgggaaaa aaaacacaaa aaaacccagc agggggcagc   1800

actggggaaa aggttgaatg gagtcactga gactcaggga tctgtgtcct agacagtcag   1860

aaatagaaag ctgaagttct agagtgaagg agttatctca gcaaggatgg atacaaagaa   1920

acgtcggaag tagagggaac ctaaatggaa actctctgct gtccttcatg attgattagc   1980

ctgtttcagc aatttataca tcagaaatct ttagttcctg atgaattaaa aaaagaggta   2040

ctagttcatc tgtgatttag gttcatctgc aggaaataaa ggaatcaaaa taaacttcat   2100

tttg                                                                2104


<210>  39
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ser Leu Gln Ala Pro Arg Arg Leu Leu Glu Leu Ala Gly Gln Ser 
1               5                   10                  15


Leu Leu Gly Asp Gln Ala Leu Ala Ile Ser Ile Leu Asp Glu Leu Pro 
            20                  25                  30


Arg Glu Leu Phe Pro Pro Leu Phe Val Glu Ala Phe Thr Ser Arg Arg 
        35                  40                  45


Cys Glu Val Leu Lys Val Met Val Gln Ala Trp Pro Phe Pro Cys Leu 
    50                  55                  60


Pro Leu Gly Ser Leu Met Lys Thr Pro Asp Leu Glu Ile Leu His Tyr 
65                  70                  75                  80


Val Val Asp Gly Ile Asp Cys Leu Leu Ala Gln Lys Val Arg Pro Arg 
                85                  90                  95


Arg Arg Lys Leu Gln Val Leu Glu Leu Arg Asp Val Asp Glu Asn Phe 
            100                 105                 110


Trp Thr Ile Trp Ser Gly Ala Arg Pro Leu Ser Cys Ser Pro Glu Ala 
        115                 120                 125


Met Ser Lys Arg Gln Thr Val Glu Asp Cys Pro Arg Thr Gly Glu Lys 
    130                 135                 140


Gln Pro Leu Lys Val Phe Met Asp Val Cys Leu Lys Glu Lys Phe Met 
145                 150                 155                 160


Asp Glu Asp Leu Ser Phe Phe Ser Gly Trp Val Gln His Arg Arg Gly 
                165                 170                 175


Ser Val His Leu Cys Cys Thr Lys Val Val Asn Tyr Ser Met Ser Ile 
            180                 185                 190


Leu Asn Phe Arg Asn Ile Leu Glu Thr Val Tyr Pro Asp Ser Ile Gln 
        195                 200                 205


Val Leu Glu Ile Trp Asn Met Cys Trp Pro Cys Met Ile Val Glu Phe 
    210                 215                 220


Ile Arg Tyr Leu Ser Gln Met Arg Asn Leu Arg Lys Leu Phe Ile Ser 
225                 230                 235                 240


Asp Gly Cys Arg Tyr Leu Leu Ser Ser Asp Ser Gln Glu Gln Leu Val 
                245                 250                 255


Ala Glu Phe Ser Ser Val Leu Leu Arg Leu Glu Tyr Leu Gln Met Leu 
            260                 265                 270


Tyr Val Arg Arg Val Cys Phe Phe Arg Gly His Leu Asp Gln Leu Ile 
        275                 280                 285


Arg Cys Leu Arg Ser Pro Leu Glu Thr Leu Ala Leu Thr Tyr Gly Phe 
    290                 295                 300


Leu Glu Lys Val Asp Leu Lys Cys Leu Pro Arg Tyr Pro Ser Leu Ser 
305                 310                 315                 320


Gln Leu Lys Gln Leu Asn Leu Ser His Gly Ala Leu Arg Phe Ile Arg 
                325                 330                 335


Leu Glu Pro Leu Arg Ala Leu Leu Glu Lys Val Ala Ala Thr Leu Gln 
            340                 345                 350


Thr Leu Phe Leu Val Asp Cys Gly Ile Arg Asp Ser Lys Leu Arg Val 
        355                 360                 365


Ile Leu Pro Ala Leu Ser Cys Cys Ser Asn Leu Thr Thr Phe Cys Phe 
    370                 375                 380


His Gly Asn Asp Thr Ser Met Asp Gly Leu Lys Asp Leu Leu Arg His 
385                 390                 395                 400


Thr Gly Arg Leu Ser Asn Leu Ser Leu Glu Thr Tyr Pro Ala Pro Arg 
                405                 410                 415


Glu Ser Leu Asp Asp Arg Gly Arg Val Ile Ser Glu Leu Leu Thr Pro 
            420                 425                 430


Leu Gln Ala Glu Leu Met Arg Ile Leu Arg Glu Val Arg Glu Pro Lys 
        435                 440                 445


Arg Ile Phe Phe Gly Pro Val Ser Cys Pro Cys Cys Gly Thr Ser Pro 
    450                 455                 460


Thr Glu Gln Leu Glu Phe Asn Phe Cys Leu Trp Gly Arg Pro Ala 
465                 470                 475


<210>  40
<211>  1855
<212>  DNA
<213>  Homo sapiens

<400>  40
acccaaagtc ttcaagcctg gagttcctgc ttggttcttc ctgaggactg agcaccttct     60

agactacatc cagatctgtt ttccctgcag attcgtgaag atgagcatcc ggactccacc    120

cagactcctg gagcttgcag ggcggagcct gctgagggac caagccttgg ccatgtccac    180

cctggaggag ctgcccacag aacttttccc cccactgttc atggaggcct tcagcaggag    240

acgctgtgag gccctgaagc tgatggtgca ggcctggccc ttccgccgcc tccctctgag    300

gcctctgata aagatgcctt gtctggaggc cttccaagct gtgctcgatg ggctggatgc    360

actgcttacc caaggggttc atcccaggag gtggaaactt caagtgctgg atttacagga    420

tgtctgtgag aacttctgga tggtttggtc tgaagctatg gcccatgggt gcttcctcaa    480

tgccaagagg aacaaaaaac cagtgcagga ctgtccaagg atgagaggac agcagccctt    540

gactgtgttc gtagaacttt ggctcaagaa caggactctg gatgaatacc tcacctgcct    600

ccttctatgg gtcaagcaga ggaaagattt actacacctg tgctgtaaga agctgaaaat    660

tttgggaatg cccttccgca atatcagaag catcctgaaa atggtgaacc tagactgtat    720

ccaggaggtg gaagtgaatt gcaagtgggt actgcccatc ctgacacagt ttaccccata    780

cctgggccac atgaggaatc ttcagaagct cgttctctcc cacatggatg tctctcgcta    840

cgtttcccca gagcagaaga aggagattgt tacccagttc accactcagt tcctcaagct    900

gtgctgcctc caaaagcttt ctatgaactc tgtttctttc ctcgaaggcc acctggacca    960

gctgctcagc tgtctgaaga cctcgttaaa ggtcctcaca ataactaact gtgtgctttt   1020

ggaatcagac ttgaagcatc tatcccagtg cccgagtatc agtcaactaa agaccctgga   1080

cctgagtggc atcagactga ccaattacag tcttgtgcct ctccaaattc tcctagaaaa   1140

agttgcagcc acccttgagt acctggattt agatgactgt ggcatcatag actcccaagt   1200

caacgccatc ctgcctgccc tgagccgctg ctttgagctc aacaccttca gcttctgtgg   1260

aaatcccatc tccatggcca ccctggagaa cctgctgagc cacacaatca tactcaaaaa   1320

cttatgcgtg gagctgtatc ctgccccccg ggagagttat gatgctgatg gtactctctg   1380

ctggagcaga tttgctcaaa ttagggctga gctgatgaag agagtgaggg acttaaggca   1440

ccccaagagg atcttgttct gtactgactg ctgccctgac tgtggcaaca ggtcatttta   1500

tgacctggag gcagatcaat gctgctgttg aatgcctgcc tatttgggtg gatatgtcaa   1560

acgctttctt ctggacactt ggaaactaaa acctaggtct taggtacatc ctatagggag   1620

cacagaaccc atcatttcac acatgggctc tgaaagtggg aaaggaaagg tgatcaagca   1680

ggggcaggac ttgggggaag tgttgccatg gattcgatgg gactttgggg acctgtgtcc   1740

tgtagagtgg aaaatgggaa tttgaatgtc tagagtggag gcttgagaat acttgaggga   1800

gttactcttg gatgcatggt tgtaaagaaa caatcagaaa taaaggaaaa ctgag        1855


<210>  41
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ser Ile Arg Thr Pro Pro Arg Leu Leu Glu Leu Ala Gly Arg Ser 
1               5                   10                  15


Leu Leu Arg Asp Gln Ala Leu Ala Met Ser Thr Leu Glu Glu Leu Pro 
            20                  25                  30


Thr Glu Leu Phe Pro Pro Leu Phe Met Glu Ala Phe Ser Arg Arg Arg 
        35                  40                  45


Cys Glu Ala Leu Lys Leu Met Val Gln Ala Trp Pro Phe Arg Arg Leu 
    50                  55                  60


Pro Leu Arg Pro Leu Ile Lys Met Pro Cys Leu Glu Ala Phe Gln Ala 
65                  70                  75                  80


Val Leu Asp Gly Leu Asp Ala Leu Leu Thr Gln Gly Val His Pro Arg 
                85                  90                  95


Arg Trp Lys Leu Gln Val Leu Asp Leu Gln Asp Val Cys Glu Asn Phe 
            100                 105                 110


Trp Met Val Trp Ser Glu Ala Met Ala His Gly Cys Phe Leu Asn Ala 
        115                 120                 125


Lys Arg Asn Lys Lys Pro Val Gln Asp Cys Pro Arg Met Arg Gly Gln 
    130                 135                 140


Gln Pro Leu Thr Val Phe Val Glu Leu Trp Leu Lys Asn Arg Thr Leu 
145                 150                 155                 160


Asp Glu Tyr Leu Thr Cys Leu Leu Leu Trp Val Lys Gln Arg Lys Asp 
                165                 170                 175


Leu Leu His Leu Cys Cys Lys Lys Leu Lys Ile Leu Gly Met Pro Phe 
            180                 185                 190


Arg Asn Ile Arg Ser Ile Leu Lys Met Val Asn Leu Asp Cys Ile Gln 
        195                 200                 205


Glu Val Glu Val Asn Cys Lys Trp Val Leu Pro Ile Leu Thr Gln Phe 
    210                 215                 220


Thr Pro Tyr Leu Gly His Met Arg Asn Leu Gln Lys Leu Val Leu Ser 
225                 230                 235                 240


His Met Asp Val Ser Arg Tyr Val Ser Pro Glu Gln Lys Lys Glu Ile 
                245                 250                 255


Val Thr Gln Phe Thr Thr Gln Phe Leu Lys Leu Cys Cys Leu Gln Lys 
            260                 265                 270


Leu Ser Met Asn Ser Val Ser Phe Leu Glu Gly His Leu Asp Gln Leu 
        275                 280                 285


Leu Ser Cys Leu Lys Thr Ser Leu Lys Val Leu Thr Ile Thr Asn Cys 
    290                 295                 300


Val Leu Leu Glu Ser Asp Leu Lys His Leu Ser Gln Cys Pro Ser Ile 
305                 310                 315                 320


Ser Gln Leu Lys Thr Leu Asp Leu Ser Gly Ile Arg Leu Thr Asn Tyr 
                325                 330                 335


Ser Leu Val Pro Leu Gln Ile Leu Leu Glu Lys Val Ala Ala Thr Leu 
            340                 345                 350


Glu Tyr Leu Asp Leu Asp Asp Cys Gly Ile Ile Asp Ser Gln Val Asn 
        355                 360                 365


Ala Ile Leu Pro Ala Leu Ser Arg Cys Phe Glu Leu Asn Thr Phe Ser 
    370                 375                 380


Phe Cys Gly Asn Pro Ile Ser Met Ala Thr Leu Glu Asn Leu Leu Ser 
385                 390                 395                 400


His Thr Ile Ile Leu Lys Asn Leu Cys Val Glu Leu Tyr Pro Ala Pro 
                405                 410                 415


Arg Glu Ser Tyr Asp Ala Asp Gly Thr Leu Cys Trp Ser Arg Phe Ala 
            420                 425                 430


Gln Ile Arg Ala Glu Leu Met Lys Arg Val Arg Asp Leu Arg His Pro 
        435                 440                 445


Lys Arg Ile Leu Phe Cys Thr Asp Cys Cys Pro Asp Cys Gly Asn Arg 
    450                 455                 460


Ser Phe Tyr Asp Leu Glu Ala Asp Gln Cys Cys Cys 
465                 470                 475


<210>  42
<211>  1295
<212>  DNA
<213>  Homo sapiens

<400>  42
atgggactca acttctacac accaccacca cttaatcgtg attcccccaa acagcagagc     60

ctcagcagcc agcagaggag gtggaaactt caagtgctgg acttgctgga tgttgatgag    120

aatgtctggg ctggatggcc tggaggctag gccctgtcct cctccccaga ggccatgagt    180

aagaggcaga cagcagagga ctatccaagg atgggagagc accagccctt aaaggtgttc    240

atagacgtct gcctcaagga aacaccccaa gatgaatgcc tgagatacct cttccagtgg    300

gtttaccaaa ggagagtttt agtacacctg tgctgtagta agttggtgaa ttatctaaca    360

cccattaaat atcttagaaa gtcattgaaa atagtccacc tgaatagtat tcaggagttg    420

gaaattcaca acatgtcctg gctgcatctg ataagaaagc ttcattgtta cctgaaggag    480

atgaagaatc ttcgcaaact cgttttctcc aggtgccatc attactcttc ggacaatgac    540

ctcgaggaat ggttactcac caaattcagc ctgtgttcct caggctggaa cacctccaat    600

tgcttaaagt aaaattgatc accttcttca gtgggcacct ggaacagctg atcaggtgcc    660

tccagaaccc cttggagaac ttggagttaa cttgtggcta cctattggaa gaagacatga    720

agtgtctgtc tcagtaccca agcctcagct acctaaagca tctgaatctc agctacgtgc    780

tgctgttccg catcagtctt gaacccctcg gagctctgct agagaaaatt gctgccactc    840

tcaagaccct catcttcgag ggctgtcaga tccactactg ccaactcagc gccatcctgc    900

ctggcctgag ccgctgctcc cagctcacca ccttctactt tggcagaaat tgcatgtcta    960

cggacaccct gaaggacctg ctgcgccaca ccagtgggct gagcaagtta agcctggaga   1020

cgtatcctgc ccctgaggag agtttgaatt ccttggttcg tgtcgattgg gagatcttcg   1080

ccccactttg ggctgagctg atgtgtacac tgagggaagt caggcagccc aagaggatct   1140

tcactggtcc cactccctgc ccttcctgtg gctcatcacc gtctgaggaa ctggagctcc   1200

atctttgctg ctagggaagg cgtgcctagt ggggttgata aatccaaagt tctcttccag   1260

gcacttggac actaaaatct agtatgtaag tgcaa                              1295


<210>  43
<211>  1844
<212>  DNA
<213>  Homo sapiens

<400>  43
gaactactgc ttgattctct gagagatccc agcaccctac aaactgagtc cagatctgag     60

ttttcccttg cagattcatc aagatgagca tcagggcccc acccagactc ctggagctgg    120

caaggcagag gctgctgagg gaccaggcct tggccatctc caccatggag gagctgccca    180

gggagctctt ccccacactg ttcatggagg ccttcagcag gagacgctgt gaaaccctga    240

aaacaatggt gcaggcctgg cctttcaccc gcctccctct agggtccctg atgaagtcgc    300

ctcatctgga gtcattaaaa tctgtgctgg aaggggttga tgtgctgttg acccaagagg    360

ttcgccccag gcagtcaaaa cttcaagtgc tggacttgag gaatgtggat gagaacttct    420

gcgacatatt ttctggagct actgcatcct tcccggaggc tctgagtcag aagcaaacag    480

cagataactg tccagggaca ggcaggcagc agccattcat ggtgttcata gacctttgtc    540

tcaagaacag gacactagat gaatgcctca cccacctctt agagtggggc aagcagagaa    600

aaggcttact gcatgtgtgt tgccaggagc tgcaggtttt tggaatgccc atccacagta    660

tcatagaggt cctgaacatg gtggagcttg actgtatcca ggaggtggaa gtgtgctgcc    720

cctgggagct gtccactctt gtgaagtttg ccccttacct gggccagatg aggaatctcc    780

gcaaacttgt tctcttcaac atccgtgcat ctgcctgcat tcccccagac aacaaggggc    840

agttcattgc ccgattcacc tctcagttcc tcaagctgga ctatttccag aatctgtcta    900

tgcactccgt ctctttcctc gaaggccacc tggaccagct gctcaggtgt ctccaggcct    960

ccttggagat ggtcgttatg accgactgcc tgctgtcaga gtcggacttg aagcatctct   1020

cttggtgccc gagcatccgt caattaaagg agctggacct gaggggtgtc acactgaccc   1080

atttcagccc tgagcccctc acaggtctgc tggagcaagt tgtggccacc ctgcagaccc   1140

tggacttaga ggactgtggg atcatggatt cccaactcag cgccatcctg cctgtcctga   1200

gccgctgctc ccagctcagc accttcagct tctgtgggaa cctcatctcc atggctgccc   1260

ttgagaacct gctgcgccac accgtcgggc tgagcaagct aagcctggag ctgtatcctg   1320

cccctctgga gagttatgac acccagggtg ctctctgctg ggggagattt gctgaacttg   1380

gggctgagct gatgaagaca ctgagggact taaggcagcc caagatcatt gtgttctgca   1440

ccgtcccctg ccctcgctgt ggcatcaggg cctcctatga cctggagccc agtcactgcc   1500

tctgttgaat gcctgccatc agggtggata tatttcaagc tttcttctgg tcatttcgga   1560

gctgaaacct aggccatgag tgcatgttaa agggagcaca gacccatcgt ttcaaatgcc   1620

tcctcagtgt gaatgggaaa ggaatgagga tgcaggaggg gcaggactgg gggaaaagtt   1680

gacttggagt ggatgggctc tttagagacc tgtgtcccag agaatcagaa atgggaatct   1740

gaattgctag agtgagaatc agggaggaga gacacatgag agggttaccc ctgcacagat   1800

ggttgtaaag taacagtcag aaataaaggg aaactgagtg gaaa                    1844


<210>  44
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ser Ile Arg Ala Pro Pro Arg Leu Leu Glu Leu Ala Arg Gln Arg 
1               5                   10                  15


Leu Leu Arg Asp Gln Ala Leu Ala Ile Ser Thr Met Glu Glu Leu Pro 
            20                  25                  30


Arg Glu Leu Phe Pro Thr Leu Phe Met Glu Ala Phe Ser Arg Arg Arg 
        35                  40                  45


Cys Glu Thr Leu Lys Thr Met Val Gln Ala Trp Pro Phe Thr Arg Leu 
    50                  55                  60


Pro Leu Gly Ser Leu Met Lys Ser Pro His Leu Glu Ser Leu Lys Ser 
65                  70                  75                  80


Val Leu Glu Gly Val Asp Val Leu Leu Thr Gln Glu Val Arg Pro Arg 
                85                  90                  95


Gln Ser Lys Leu Gln Val Leu Asp Leu Arg Asn Val Asp Glu Asn Phe 
            100                 105                 110


Cys Asp Ile Phe Ser Gly Ala Thr Ala Ser Phe Pro Glu Ala Leu Ser 
        115                 120                 125


Gln Lys Gln Thr Ala Asp Asn Cys Pro Gly Thr Gly Arg Gln Gln Pro 
    130                 135                 140


Phe Met Val Phe Ile Asp Leu Cys Leu Lys Asn Arg Thr Leu Asp Glu 
145                 150                 155                 160


Cys Leu Thr His Leu Leu Glu Trp Gly Lys Gln Arg Lys Gly Leu Leu 
                165                 170                 175


His Val Cys Cys Gln Glu Leu Gln Val Phe Gly Met Pro Ile His Ser 
            180                 185                 190


Ile Ile Glu Val Leu Asn Met Val Glu Leu Asp Cys Ile Gln Glu Val 
        195                 200                 205


Glu Val Cys Cys Pro Trp Glu Leu Ser Thr Leu Val Lys Phe Ala Pro 
    210                 215                 220


Tyr Leu Gly Gln Met Arg Asn Leu Arg Lys Leu Val Leu Phe Asn Ile 
225                 230                 235                 240


Arg Ala Ser Ala Cys Ile Pro Pro Asp Asn Lys Gly Gln Phe Ile Ala 
                245                 250                 255


Arg Phe Thr Ser Gln Phe Leu Lys Leu Asp Tyr Phe Gln Asn Leu Ser 
            260                 265                 270


Met His Ser Val Ser Phe Leu Glu Gly His Leu Asp Gln Leu Leu Arg 
        275                 280                 285


Cys Leu Gln Ala Ser Leu Glu Met Val Val Met Thr Asp Cys Leu Leu 
    290                 295                 300


Ser Glu Ser Asp Leu Lys His Leu Ser Trp Cys Pro Ser Ile Arg Gln 
305                 310                 315                 320


Leu Lys Glu Leu Asp Leu Arg Gly Val Thr Leu Thr His Phe Ser Pro 
                325                 330                 335


Glu Pro Leu Thr Gly Leu Leu Glu Gln Val Val Ala Thr Leu Gln Thr 
            340                 345                 350


Leu Asp Leu Glu Asp Cys Gly Ile Met Asp Ser Gln Leu Ser Ala Ile 
        355                 360                 365


Leu Pro Val Leu Ser Arg Cys Ser Gln Leu Ser Thr Phe Ser Phe Cys 
    370                 375                 380


Gly Asn Leu Ile Ser Met Ala Ala Leu Glu Asn Leu Leu Arg His Thr 
385                 390                 395                 400


Val Gly Leu Ser Lys Leu Ser Leu Glu Leu Tyr Pro Ala Pro Leu Glu 
                405                 410                 415


Ser Tyr Asp Thr Gln Gly Ala Leu Cys Trp Gly Arg Phe Ala Glu Leu 
            420                 425                 430


Gly Ala Glu Leu Met Lys Thr Leu Arg Asp Leu Arg Gln Pro Lys Ile 
        435                 440                 445


Ile Val Phe Cys Thr Val Pro Cys Pro Arg Cys Gly Ile Arg Ala Ser 
    450                 455                 460


Tyr Asp Leu Glu Pro Ser His Cys Leu Cys 
465                 470


<210>  45
<211>  1473
<212>  DNA
<213>  Homo sapiens

<400>  45
atgcaacctg gtgtcagtgg aagagttttt cctcggagat ttgtcagaat gagcctccag     60

gccccatcca gactgctgga gctggcaggg cagagcctgc tgaggaacca gttcttgacc    120

atcttcaccc tggatgagct gcccagggag gtcttccctc tgatgttcat ggaggccttc    180

agcatgagac gttttgaggc cctgaagctg atggtgcagg cctggccctt cctccgcctc    240

cctctgggat ccctgatgaa gacacctcat ctggagacct tgcaagctgt cctgagggga    300

cttgatacac tggtggccca gaaggttcgc cccaggaggt ggaaacttca agtgctggat    360

ttgcgggatg ttgatgagaa tttctggacc atatggtctg gagccagggt cctctcctgc    420

tccccagagg ccatgagtaa gaggcagaca gtggaggact gtccaaggat gggagagcgc    480

cagcccttga aggtgttcat agacctctgc ctaaaggaaa gtacactgga tgaatgcctg    540

agctaccttt ttgggtggat ccactacaga agaggcctag tgcacctgtg ttgtagtaag    600

gtgcagaatt actcaatgcc cacttcaagt ttcagaaatc tattggaaag gatataccca    660

gacagtatcc aggagttgga agtctggaaa aagtgctctc tcaataaaac gggaaagttt    720

gccccttacc tgagccagat gagcaatctt cgtgaactct ttttagcctt cggttatgag    780

cgtgagttgt acgtgagcgt ccagtagccg tgcattcctg acttggactc tccattcctc    840

tgcctgtact acccccagat gctttatata aaaaagatca gtaatatcaa agagcacctg    900

gagcacctgc tcaggtacct caagaacccc ttgggggcct ttatattcag tgatgcttac    960

ctaactgatc gggacatgga gtgtctgtct cagtacccaa gcctcagtca gctaaaggag   1020

ctgcgtctga ttcatatcct aatgtggacc accaatcttg agccccttgg agttctgctg   1080

gagaaagttg ctgctactct caagaccctc gtcttaaagg actgtcggat ccaggacccc   1140

caactcaggg tcctcctgcc tgccctgagc cactgttccc agctcaccac cttcaacttt   1200

catggaaatg agacctccat gaatgctctg aaagacctgc tgcgtcacac acgtgggctg   1260

agcaagttag gcctggagtt gtatcctgcc cctctggaga gtcttgacta caagggtcat   1320

gtcaattggg agatcctcac cccaattcgg gctgagctga tgcgtacact cagggaagtc   1380

aggcagccca agaggatctt ctttggtccc gtcccttgcc ctacctgtgg ctcatggcca   1440

tctgagaaag tggacttcca tctttgctcc tag                                1473


<210>  46
<211>  1863
<212>  DNA
<213>  Homo sapiens

<400>  46
acccaaagtc ttcaagcctg gagttcctgc ttggttcttc ctgaggtctg agcaccttct     60

agactacatc cagatctgtt ttccctgcag attcatgaag atgagcatcc ggactccacc    120

cagactcctg gagcttgcag ggcggagcct gctgagggac caagctttgg ccatgtccac    180

cctggaggag ctgcccacag aacttttccc cccactgttc atggaggcct tcagcaggag    240

acgctgtgag gccctgaagc tgatggtgca ggcctggccc ttccgccgcc tccctctgag    300

gcctctgata aagatgcctt gtctggaggc cttccaagct gtgctcgatg ggcttgatgc    360

actgcttacc caaggggttc gtcccaggag gtggaaactc caagtgctgg atttacagga    420

tgtctgtgag aacttctgga tggtttggtc tgaagctatg gcccatgggt gcttcctcaa    480

tgccaagagg aacaaaaaac cagtgcagga ctgtccaagg atgagaggac ggcagccctt    540

gactgtgttc gtagaacttt ggctcaagaa caggactctg gatgaatacc tcacctacct    600

ccttctatgg gtcaagcaga ggaaagattt actacacctg tgctgtaaga agctgaaaat    660

tttgggaatg cccttccgca atatcagaag catcctgaaa atggtgaacc tagactgtat    720

ccaggaggtg gaagtgaatt gcaagtgggt actgcccatc ctgacacagt ttaccccata    780

cctgggccac atgaggaatc ttcagaagct cgttctctcc cacatggatg tctctcgcta    840

cgtttcccca gagcagaaga aggagattgt tacccagttc accactcagt tcctcaagct    900

gcgctgcctc caaaagcttt atatgaactc tgtttctttc ctcgaaggcc acctggacca    960

gctgctcagc tgtctgaaga cctcgttaaa agtcctcaca ataactaact gtgtgctttt   1020

ggaatcagac ttgaagcatc tatcccagtg cccgagtatc agtcaactaa agaccctgga   1080

cctgagtggc atcagactga ccaattatag tcttgtgcct ctccaaattc tcctagaaaa   1140

agttgcagcc acccttgagt acctggattt agatgactgt ggcatcatag actcccaagt   1200

caacgccatc ctgcctgccc tgagccgctg ctttgagctc aacaccttca gcttctgtgg   1260

aaatcccatc tgcatggcca ccctggagaa cctgctgagc cacacaatca tactcaaaaa   1320

cttatgtgtg gagctgtatc ctgccccccg agagagttat ggtgctgatg gtactctctg   1380

ctggagcaga tttgctcaaa ttagggctga gctgatgaac agagtgaggg acttaaggca   1440

ccccaagagg atcttgttct gtactgacta ctgccctgac tgtggcaaca ggtcatttta   1500

tgacctggag gcagatcaat actgctgttg aatgcctgcc tatttggatg ggtatgtcaa   1560

acgctttctt ctggacactt ggaaactaaa acctaggtct taggtacatc ctaaagggag   1620

cacagaaccc atcatttcac acataggctc tgaaagtggg aaaggaaagc tgatcaagca   1680

ggggccggac ttgggggaaa tgttgccatg gattcgatgg gactttgggg acctgtgtcc   1740

tgtagattcg aaaatgggaa tctgaatgtc tagagtggaa ttcaggcttg agaatacatg   1800

agggagttac tcttgcatgg atggttgtaa agaaacaatc agaaataaag gaaaactgag   1860

cag                                                                 1863


<210>  47
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Lys Met Ser Ile Arg Thr Pro Pro Arg Leu Leu Glu Leu Ala Gly 
1               5                   10                  15


Arg Ser Leu Leu Arg Asp Gln Ala Leu Ala Met Ser Thr Leu Glu Glu 
            20                  25                  30


Leu Pro Thr Glu Leu Phe Pro Pro Leu Phe Met Glu Ala Phe Ser Arg 
        35                  40                  45


Arg Arg Cys Glu Ala Leu Lys Leu Met Val Gln Ala Trp Pro Phe Arg 
    50                  55                  60


Arg Leu Pro Leu Arg Pro Leu Ile Lys Met Pro Cys Leu Glu Ala Phe 
65                  70                  75                  80


Gln Ala Val Leu Asp Gly Leu Asp Ala Leu Leu Thr Gln Gly Val Arg 
                85                  90                  95


Pro Arg Arg Trp Lys Leu Gln Val Leu Asp Leu Gln Asp Val Cys Glu 
            100                 105                 110


Asn Phe Trp Met Val Trp Ser Glu Ala Met Ala His Gly Cys Phe Leu 
        115                 120                 125


Asn Ala Lys Arg Asn Lys Lys Pro Val Gln Asp Cys Pro Arg Met Arg 
    130                 135                 140


Gly Arg Gln Pro Leu Thr Val Phe Val Glu Leu Trp Leu Lys Asn Arg 
145                 150                 155                 160


Thr Leu Asp Glu Tyr Leu Thr Tyr Leu Leu Leu Trp Val Lys Gln Arg 
                165                 170                 175


Lys Asp Leu Leu His Leu Cys Cys Lys Lys Leu Lys Ile Leu Gly Met 
            180                 185                 190


Pro Phe Arg Asn Ile Arg Ser Ile Leu Lys Met Val Asn Leu Asp Cys 
        195                 200                 205


Ile Gln Glu Val Glu Val Asn Cys Lys Trp Val Leu Pro Ile Leu Thr 
    210                 215                 220


Gln Phe Thr Pro Tyr Leu Gly His Met Arg Asn Leu Gln Lys Leu Val 
225                 230                 235                 240


Leu Ser His Met Asp Val Ser Arg Tyr Val Ser Pro Glu Gln Lys Lys 
                245                 250                 255


Glu Ile Val Thr Gln Phe Thr Thr Gln Phe Leu Lys Leu Arg Cys Leu 
            260                 265                 270


Gln Lys Leu Tyr Met Asn Ser Val Ser Phe Leu Glu Gly His Leu Asp 
        275                 280                 285


Gln Leu Leu Ser Cys Leu Lys Thr Ser Leu Lys Val Leu Thr Ile Thr 
    290                 295                 300


Asn Cys Val Leu Leu Glu Ser Asp Leu Lys His Leu Ser Gln Cys Pro 
305                 310                 315                 320


Ser Ile Ser Gln Leu Lys Thr Leu Asp Leu Ser Gly Ile Arg Leu Thr 
                325                 330                 335


Asn Tyr Ser Leu Val Pro Leu Gln Ile Leu Leu Glu Lys Val Ala Ala 
            340                 345                 350


Thr Leu Glu Tyr Leu Asp Leu Asp Asp Cys Gly Ile Ile Asp Ser Gln 
        355                 360                 365


Val Asn Ala Ile Leu Pro Ala Leu Ser Arg Cys Phe Glu Leu Asn Thr 
    370                 375                 380


Phe Ser Phe Cys Gly Asn Pro Ile Cys Met Ala Thr Leu Glu Asn Leu 
385                 390                 395                 400


Leu Ser His Thr Ile Ile Leu Lys Asn Leu Cys Val Glu Leu Tyr Pro 
                405                 410                 415


Ala Pro Arg Glu Ser Tyr Gly Ala Asp Gly Thr Leu Cys Trp Ser Arg 
            420                 425                 430


Phe Ala Gln Ile Arg Ala Glu Leu Met Asn Arg Val Arg Asp Leu Arg 
        435                 440                 445


His Pro Lys Arg Ile Leu Phe Cys Thr Asp Tyr Cys Pro Asp Cys Gly 
    450                 455                 460


Asn Arg Ser Phe Tyr Asp Leu Glu Ala Asp Gln Tyr Cys Cys 
465                 470                 475


<210>  48
<211>  1844
<212>  DNA
<213>  Homo sapiens

<400>  48
gaactactgc ttgattctct gagagatccc agcaccctac aaactgagtc cagatctgag     60

ttttcccttg cagattcatc aagatgagca tcagggcccc acccagactc ctggagctgg    120

caaggcagag gctgctgagg gaccaggcct tggccatctc caccatggag gagctgccca    180

gggagctctt ccccacactg ttcatggagg ccttcagcag gagacgctgt gaaaccctga    240

aaacaatggt gcaggcctgg cctttcaccc gcctccctct agggtccctg atgaagtcgc    300

ctcatctgga gtcattaaaa tctgtgctgg aaggggttga tgtgctgttg acccaagagg    360

ttcgccccag gcagtcaaaa cttcaagtgc tggacttgag gaatgtggat gagaacttct    420

gcgacatatt ttctggagct actgcatcct tcccggaggc tctgagtcag aagcaaacag    480

cagataactg tccagggaca ggcaggcagc agccattcat ggtgttcata gacctttgtc    540

tcaagaacag gacactagat gaatgcctca cccacctctt agagtggggc aagcagagaa    600

aaggcttact gcatgtgtgt tgcaaggagc tgcaggtttt tggaatgccc atccacagta    660

tcatagaggt cctgaacatg gtggagcttg actgtatcca ggaggtggaa gtgtgctgcc    720

cctgggagct gtccactctt gtgaagtttg ccccttacct gggccagatg aggaatctcc    780

gcaaacttgt tctcttcaac atccgtgcat ctgcctgcat tcccccagac aacaaggggc    840

agttcattgc ccgattcacc tctcagttcc tcaagctgga ctatttccag aatctgtcta    900

tgcactccgt ctctttcctc gaaggccacc tggaccagct gctcaggtgt ctccaggcct    960

ccttggagat ggtcgttatg accgactgcc tgctgtcaga gtcggacttg aagcatctct   1020

cttggtgccc gagcatccgt caattaaagg agctggacct gaggggtgtc acactgaccc   1080

atttcagccc tgagcccctc acaggtctgc tggagcaagt tgtggccacc ctgcagaccc   1140

tggacttaga ggactgtggg atcatggatt cccaactcag cgccatcctg cctgtcctga   1200

gccgctgctc ccagctcagc accttcagct tctgtgggaa cctcatctcc atggctgccc   1260

ttgagaacct gctgcgccac accgtcgggc tgagcaagct aagcctggag ctgtatcctg   1320

cccctctgga gagttatgac acccagggtg ctctctgctg ggggagattt gctgaacttg   1380

gggctgagct gatgaagaca ctgagggact taaggcagcc caagatcatt gtgttctgca   1440

ccgtcccctg ccctcgctgt ggcatcaggg cctcctatga cctggagccc agtcactgcc   1500

tctgttgaat gcctgccatc agggtggata tatttcaagc tttcttctgg tcatttcgga   1560

gctgaaacct aggccatgag tgcatgttaa agggagcaca gacccatcgt ttcaaatgcc   1620

tcctcagtgt gaatgggaaa ggaatgagga tgcaggaggg gcaggactgg gggaaaagtt   1680

gacttggagt ggatgggctc tttagagacc tgtgtcccag agaatcagaa atgggaatct   1740

gaattgctag agtgagaatc agggaggaga gacacatgag agggttaccc ctgcacagat   1800

ggttgtaaag taacagtcag aaataaaggg aaactgagtg gaaa                    1844


<210>  49
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Ser Ile Arg Ala Pro Pro Arg Leu Leu Glu Leu Ala Arg Gln Arg 
1               5                   10                  15


Leu Leu Arg Asp Gln Ala Leu Ala Ile Ser Thr Met Glu Glu Leu Pro 
            20                  25                  30


Arg Glu Leu Phe Pro Thr Leu Phe Met Glu Ala Phe Ser Arg Arg Arg 
        35                  40                  45


Cys Glu Thr Leu Lys Thr Met Val Gln Ala Trp Pro Phe Thr Arg Leu 
    50                  55                  60


Pro Leu Gly Ser Leu Met Lys Ser Pro His Leu Glu Ser Leu Lys Ser 
65                  70                  75                  80


Val Leu Glu Gly Val Asp Val Leu Leu Thr Gln Glu Val Arg Pro Arg 
                85                  90                  95


Gln Ser Lys Leu Gln Val Leu Asp Leu Arg Asn Val Asp Glu Asn Phe 
            100                 105                 110


Cys Asp Ile Phe Ser Gly Ala Thr Ala Ser Phe Pro Glu Ala Leu Ser 
        115                 120                 125


Gln Lys Gln Thr Ala Asp Asn Cys Pro Gly Thr Gly Arg Gln Gln Pro 
    130                 135                 140


Phe Met Val Phe Ile Asp Leu Cys Leu Lys Asn Arg Thr Leu Asp Glu 
145                 150                 155                 160


Cys Leu Thr His Leu Leu Glu Trp Gly Lys Gln Arg Lys Gly Leu Leu 
                165                 170                 175


His Val Cys Cys Lys Glu Leu Gln Val Phe Gly Met Pro Ile His Ser 
            180                 185                 190


Ile Ile Glu Val Leu Asn Met Val Glu Leu Asp Cys Ile Gln Glu Val 
        195                 200                 205


Glu Val Cys Cys Pro Trp Glu Leu Ser Thr Leu Val Lys Phe Ala Pro 
    210                 215                 220


Tyr Leu Gly Gln Met Arg Asn Leu Arg Lys Leu Val Leu Phe Asn Ile 
225                 230                 235                 240


Arg Ala Ser Ala Cys Ile Pro Pro Asp Asn Lys Gly Gln Phe Ile Ala 
                245                 250                 255


Arg Phe Thr Ser Gln Phe Leu Lys Leu Asp Tyr Phe Gln Asn Leu Ser 
            260                 265                 270


Met His Ser Val Ser Phe Leu Glu Gly His Leu Asp Gln Leu Leu Arg 
        275                 280                 285


Cys Leu Gln Ala Ser Leu Glu Met Val Val Met Thr Asp Cys Leu Leu 
    290                 295                 300


Ser Glu Ser Asp Leu Lys His Leu Ser Trp Cys Pro Ser Ile Arg Gln 
305                 310                 315                 320


Leu Lys Glu Leu Asp Leu Arg Gly Val Thr Leu Thr His Phe Ser Pro 
                325                 330                 335


Glu Pro Leu Thr Gly Leu Leu Glu Gln Val Val Ala Thr Leu Gln Thr 
            340                 345                 350


Leu Asp Leu Glu Asp Cys Gly Ile Met Asp Ser Gln Leu Ser Ala Ile 
        355                 360                 365


Leu Pro Val Leu Ser Arg Cys Ser Gln Leu Ser Thr Phe Ser Phe Cys 
    370                 375                 380


Gly Asn Leu Ile Ser Met Ala Ala Leu Glu Asn Leu Leu Arg His Thr 
385                 390                 395                 400


Val Gly Leu Ser Lys Leu Ser Leu Glu Leu Tyr Pro Ala Pro Leu Glu 
                405                 410                 415


Ser Tyr Asp Thr Gln Gly Ala Leu Cys Trp Gly Arg Phe Ala Glu Leu 
            420                 425                 430


Gly Ala Glu Leu Met Lys Thr Leu Arg Asp Leu Arg Gln Pro Lys Ile 
        435                 440                 445


Ile Val Phe Cys Thr Val Pro Cys Pro Arg Cys Gly Ile Arg Ala Ser 
    450                 455                 460


Tyr Asp Leu Glu Pro Ser His Cys Leu Cys 
465                 470


<210>  50
<211>  1473
<212>  DNA
<213>  Homo sapiens

<400>  50
atgcaacctg gtgtcagtgg aagagttttt cctcggagat ttgtcagaat gagcctccag     60

gccccatcca gactgctgga gctggcaggg cagagcctgc tgaggaacca gttcttgacc    120

atcttcaccc tggatgagct gcccagggag gtcttccctc tgatgttcat ggaggccttc    180

agcatgagac gttttgaggc cctgaagctg atggtgcagg cctggccctt cctccgcctc    240

cctctgggat ccctgatgaa gacacctcat ctggagacct tgcaagctgt cctgagggga    300

cttgatacac tggtggccca gaaggttcgc cccaggaggt ggaaacttca agtgctggat    360

ttgcgggatg ttgatgagaa tttctggacc atatggtctg gagccagggt cctctcctgc    420

tccccagagg ccatgagtaa gaggcagaca gtggaggact gtccaaggat gggagagcgc    480

cagcccttga aggtgttcat agacctctgc ctaaaggaaa gtacactgga tgaatgcctg    540

agctaccttt ttgggtggat ccactacaga agaggcctag tgcacctgtg ttgtagtaag    600

gtgcagaatt actcaatgcc cacttcaagt ttcagaaatc tattggaaag gatataccca    660

gacagtatcc aggagttgga agtctggaaa aagtgctctc tcaataaaac gggaaagttt    720

gccccttacc tgagccagat gagcaatctt cgtgaactct ttttagcctt cggttatgag    780

cgtgagttgt acgtgagcgt ccagtagccg tgcattcctg acttggactc tccattcctc    840

tgcctgtact acccccagat gctttatata aaaaagatca gtaatatcaa agagcacctg    900

gagcacctgc tcaggtacct caagaacccc ttgggggcct ttatattcag tgatgcttac    960

ctagctgatc gggacatgga gtgtctgtct cagtacccaa gcctcagtca gctaaaggag   1020

ctgcgtctga ttcatatcct aatgtggacc acccatcttg agccccttgg agttctgctg   1080

gagaaagttg ctgctactct caagaccctc gtcttaaagg actgtcggat ccaggacccc   1140

caactcaggg tcctcctgcc tgccctgagc cactgttccc agctcaccac cttcaacttt   1200

catggaaatg agacctccat gaatgctctg aaagacctgc tgcgtcacac acgtgggctg   1260

agcaagttag gcctggagtt gtatcctgcc cctctggaga gtcttgacta caagggtcat   1320

gtcaattggg agatcctcac cccaattcgg gctgagctga tgcgtacact cagggaagtc   1380

aggcagccca agaggatctt ctttggtccc gtcccttgcc ctacctgtgg ctcatggcca   1440

tctgagaaag tggacttcca tctttgctcc tag                                1473


<210>  51
<211>  2280
<212>  DNA
<213>  Homo sapiens

<400>  51
atggagctgc tgttgcagcc agttaacggg ctggtgacaa agtcgcaatt gtgtctgtgg     60

agcagggagc ctgttccatc gaggcaggct gccccaatcc gtccgcgccg cgctccatcg    120

cccccgcacg cccgggcgca cgccctcccc gcccgggccg ccctctggct ccccgcgccc    180

ggcagccagt gcctcaccgc gccgtcccgc gccagggctc gctccgagag ccgcttcctt    240

ctcgccgcgg ccggcgcggg ccccccggcc atgcgccccc gagccccagc ctgcgccgcc    300

gcggcgctcg ggctctgcag ccttctgctg ctgctcgcgc ccgggcacgc gtgccccgcg    360

ggctgcgcct gcaccgaccc gcacaccgtg gactgccgcg accgcgggct gcccagcgtg    420

ccagaccctt tccccctgga cgtgcgcaag ctgctggtgg ccggcaaccg catccagcgg    480

atccccgagg acttcttcat cttctacggc gacctggtct acctggactt caggaacaac    540

tcgctgcgct cgctggagga gggcacgttc agcggctcgg ccaagctcgt gttcctcgac    600

ctcagctaca acaacttgac ccagctgggc gccggcgcct tccgctcggc cgggaggctg    660

gtgaagctta gcctggctaa caacaacctg gtgggcgtgc acgaggacgc cttcgagacc    720

ctggagtcgc tgcaggtgct ggagctcaac gacaacaacc tgcgcagcct cagcgtggcc    780

gccctggccg cgctgcccgc gctgcgctcc ctgcgtctgg acgggaaccc ctggctgtgc    840

gactgtgact tcgcccacct cttctcctgg atccaggaga acgcatccaa actgcccaaa    900

ggccttgatg aaatccagtg ctccctgccc atggagagca ggaggatatc cctgcgtgag    960

ctgtcggagg ccagcttcag cgagtgtagg ttcagcctgt cactcacaga cctctgcatc   1020

atcattttct ccggtgtggc cgtgtccatt gcggccatca tctccagctt cttcctggcc   1080

actgtggtgc agtgcctcca gaggtgcgca cccaacaaag atgcggagga tgaagacgag   1140

gacaaggatg actgagccac ctcctccctc ctgcctctta ctctccagca ccgaaccaga   1200

agctctctcc aagacgagag ggaaatgctg aaaatggaaa agcactggcc accatctgtg   1260

aactgaacag agcctgttcc gtgtcttggc ccctgggtac acctgctggg accactgatc   1320

tcagagttta gaatcagcag agcacagaag cccaggaagg atggagggaa ttattcctgg   1380

agcataacct gcctctcaga tcgaggtgtg tgttggggga gaagatgacc gagtcaggct   1440

tcatagctga tgactaaaag cctcccccag gaaatgtgaa gactggcagc tttcaatggc   1500

aaagatgatt ttacgccatt ctttttctga cctgtactgg gagatcatga aacatctgcc   1560

ttcctcccaa gaaacagcag ctcaaacagt ggagattcaa attcggatca ttcaccacaa   1620

gaacgagaac tttgatcctt atataatagg cctcagcaac cttgggatgt tatactggga   1680

actaataaac tcgtgtgcaa tagactcaat gtttatgttc ccccagattt tatatgttga   1740

aacctaatcc ccaatgtgat ggtatttgga ggtggggctt ttgggaggtg attaggttta   1800

gatcatatca tgaggatggg gcccaaatga tgggattagt gccctcatga aaggtggccc   1860

cagagagctc cttcacccct tcaatgcttg aggatgcagc aagaaatcag ctgcccatga   1920

accgagaagc aggccctcac cagaacccag ccatgctggc acccagatct cagacttcca   1980

gcctccagaa ctgggagaaa taaataaatg tctgttgttt gtaagccact caatctctgg   2040

tattctgtta tagtggtcga aatggaccca tgaagaagct aacaactggt cagagggtgt   2100

ctgttgttaa ttttggtaag ctggttggga aaactttgac ttgacataac tcaaaccctg   2160

atctttatcc taagcggtag cgacttgtag aggaaggatt agttgctttg tacagttgtg   2220

atggtctctc tgctcagcat catttttcct tctgaaggac agacaggttg ttcccctcca   2280


<210>  52
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Glu Leu Leu Leu Gln Pro Val Asn Gly Leu Val Thr Lys Ser Gln 
1               5                   10                  15


Leu Cys Leu Trp Ser Arg Glu Pro Val Pro Ser Arg Gln Ala Ala Pro 
            20                  25                  30


Ile Arg Pro Arg Arg Ala Pro Ser Pro Pro His Ala Arg Ala His Ala 
        35                  40                  45


Leu Pro Ala Arg Ala Ala Leu Trp Leu Pro Ala Pro Gly Ser Gln Cys 
    50                  55                  60


Leu Thr Ala Pro Ser Arg Ala Arg Ala Arg Ser Glu Ser Arg Phe Leu 
65                  70                  75                  80


Leu Ala Ala Ala Gly Ala Gly Pro Pro Ala Met Arg Pro Arg Ala Pro 
                85                  90                  95


Ala Cys Ala Ala Ala Ala Leu Gly Leu Cys Ser Leu Leu Leu Leu Leu 
            100                 105                 110


Ala Pro Gly His Ala Cys Pro Ala Gly Cys Ala Cys Thr Asp Pro His 
        115                 120                 125


Thr Val Asp Cys Arg Asp Arg Gly Leu Pro Ser Val Pro Asp Pro Phe 
    130                 135                 140


Pro Leu Asp Val Arg Lys Leu Leu Val Ala Gly Asn Arg Ile Gln Arg 
145                 150                 155                 160


Ile Pro Glu Asp Phe Phe Ile Phe Tyr Gly Asp Leu Val Tyr Leu Asp 
                165                 170                 175


Phe Arg Asn Asn Ser Leu Arg Ser Leu Glu Glu Gly Thr Phe Ser Gly 
            180                 185                 190


Ser Ala Lys Leu Val Phe Leu Asp Leu Ser Tyr Asn Asn Leu Thr Gln 
        195                 200                 205


Leu Gly Ala Gly Ala Phe Arg Ser Ala Gly Arg Leu Val Lys Leu Ser 
    210                 215                 220


Leu Ala Asn Asn Asn Leu Val Gly Val His Glu Asp Ala Phe Glu Thr 
225                 230                 235                 240


Leu Glu Ser Leu Gln Val Leu Glu Leu Asn Asp Asn Asn Leu Arg Ser 
                245                 250                 255


Leu Ser Val Ala Ala Leu Ala Ala Leu Pro Ala Leu Arg Ser Leu Arg 
            260                 265                 270


Leu Asp Gly Asn Pro Trp Leu Cys Asp Cys Asp Phe Ala His Leu Phe 
        275                 280                 285


Ser Trp Ile Gln Glu Asn Ala Ser Lys Leu Pro Lys Gly Leu Asp Glu 
    290                 295                 300


Ile Gln Cys Ser Leu Pro Met Glu Ser Arg Arg Ile Ser Leu Arg Glu 
305                 310                 315                 320


Leu Ser Glu Ala Ser Phe Ser Glu Cys Arg Phe Ser Leu Ser Leu Thr 
                325                 330                 335


Asp Leu Cys Ile Ile Ile Phe Ser Gly Val Ala Val Ser Ile Ala Ala 
            340                 345                 350


Ile Ile Ser Ser Phe Phe Leu Ala Thr Val Val Gln Cys Leu Gln Arg 
        355                 360                 365


Cys Ala Pro Asn Lys Asp Ala Glu Asp Glu Asp Glu Asp Lys Asp Asp 
    370                 375                 380


<210>  53
<211>  1911
<212>  DNA
<213>  Homo sapiens

<400>  53
cagggttcta cccggctggg tccaggcaga agtttttcct ccccacctcc gggtttgtcc     60

tcatcatcgg tcactcccat tcacagcttt aagattctgg aggccaagaa tttgactccc    120

cccggatcca tggtctgtgg ataccaatgt tccgactgga gacggggagc ccgcgagacc    180

cgggtctcca gggtctgccc aaggaagttg ctcatgggag cagacctcta gagcaggatt    240

tgaggccagg ccaaagagaa ccccagagat gaaaggcctc ctcccactgg cttggttcct    300

ggcttgtagt gtgcctgctg tgcaaggagg cttgctggac ctaaaatcaa tgatcgagaa    360

ggtgacaggg aagaacgccc tgacaaacta cggcttctac ggctgttact gcggctgggg    420

cggccgagga acccccaagg atggcaccga ttggtgctgt tgggcgcatg accactgcta    480

tgggcggctg gaggagaagg gctgcaacat tcgcacacag tcctacaaat acagattcgc    540

gtggggcgtg gtcacctgcg agcccgggcc cttctgccat gtgaacctct gtgcctgtga    600

ccggaagctc gtctactgcc tcaagagaaa cctacggagc tacaacccac agtaccaata    660

ctttcccaac atcctctgct cctaggcctc cccagcgagc tcctcccaga ccaagacttt    720

tgttctgttt ttctacaaca cagagtactg actctgcctg gttcctgaga gaggctccta    780

agtcacagac ctcagtcttt ctcgaagctt ggcggacccc cagggccaca ctgtaccctc    840

cagcgagtcc caggagagtg actctggtca taggacttgg tagggtccca gggtccctag    900

gcctccactt ctgagggcag cccctctggt gccaagagct ctcctccaac tcagggttgg    960

ctgtgtctct tttcttctct gaagacagcg tcctggctcc agttggaaca ctttcctgag   1020

atgcacttac ttctcagctt ctgcgatcag attatcatca ccaccaccct ccagagaatt   1080

tttacgcaag aagagccaaa ttgactctct aaatctggtg tatgggtatt aaataaaatt   1140

cattctcaag gctaataaaa accacattgg cattttcctc tgctgtgggg gatcgctggt   1200

gcctctttct ctgccactgg ggcaataaac ccaaagatgt ctacattatc tccgaaacag   1260

aagggaagat tagtaaatgc agggttttct gggatgagct tcaggctttc tcttgggcta   1320

attttcttac accttggggt cctctccagt attgggtctc attcttcctc gatggggtca   1380

gggaaagata actggtgatt atgccagctt cagcttccag gccagagagg gtggcattca   1440

aatcccagtg ctggcttctt cagctgtgtg gtcttggacc cgttactgaa cctctttgac   1500

tttcagtctc tttgagaaat aaactgtctt gttccttgca atgtaaaatg agacttctaa   1560

agcccacctt gatgctgata tggagaatgc tgaggttcta ggatttcaca cagcaggaat   1620

ttttttttaa taggtgtcag ctgtggggtt tattttttac aaagtaagga cattaaaaaa   1680

accaacccgt ctatcaattc ataaaagaaa ggatgttctg ataccaagac tgaaagaaga   1740

aaggatgtat tccaaaacaa aggaacatcc ttccaagaaa ggacctatgg cttctttatt   1800

ccgacatacc ccaaaataac tgcatgataa ataggtctat atttaaaaag ctctagtgtc   1860

gaatgttttc aaaataaaat ttaattttat gagaaaaaaa aaaaaaaaaa a            1911


<210>  54
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Lys Gly Leu Leu Pro Leu Ala Trp Phe Leu Ala Cys Ser Val Pro 
1               5                   10                  15


Ala Val Gln Gly Gly Leu Leu Asp Leu Lys Ser Met Ile Glu Lys Val 
            20                  25                  30


Thr Gly Lys Asn Ala Leu Thr Asn Tyr Gly Phe Tyr Gly Cys Tyr Cys 
        35                  40                  45


Gly Trp Gly Gly Arg Gly Thr Pro Lys Asp Gly Thr Asp Trp Cys Cys 
    50                  55                  60


Trp Ala His Asp His Cys Tyr Gly Arg Leu Glu Glu Lys Gly Cys Asn 
65                  70                  75                  80


Ile Arg Thr Gln Ser Tyr Lys Tyr Arg Phe Ala Trp Gly Val Val Thr 
                85                  90                  95


Cys Glu Pro Gly Pro Phe Cys His Val Asn Leu Cys Ala Cys Asp Arg 
            100                 105                 110


Lys Leu Val Tyr Cys Leu Lys Arg Asn Leu Arg Ser Tyr Asn Pro Gln 
        115                 120                 125


Tyr Gln Tyr Phe Pro Asn Ile Leu Cys Ser 
    130                 135


<210>  55
<211>  2747
<212>  DNA
<213>  Homo sapiens

<400>  55
tgctctgtgc tgggatcatg gaacttgcac tgctgtgtgg gctggtggtg atggctggtg     60

tgattccaat ccagggcggg atcctgaacc tgaacaagat ggtcaagcaa gtgactggga    120

aaatgcccat cctctcctac tggccctacg gctgtcactg cggactaggt ggcagaggcc    180

aacccaaaga tgccacggac tggtgctgcc agacccatga ctgctgctat gaccacctga    240

agacccaggg gtgcagcatc tacaaggact attacagata caacttttcc caggggaaca    300

tccactgctc tgacaaggga agctggtgtg agcagcagct gtgtgcctgt gacaaggagg    360

tggccttctg cctgaagcgc aacctggaca cctaccagaa gcgactgcgt ttctactggc    420

ggccccactg ccgggggcag acccctgggt gctagaagcc cacaccctct accctgttcc    480

tcagcatgga gctctggcat ccccacctca gtatctaacc tgaaccagcc tggcttttca    540

aacactccgg ggggaggtag tcccagcctc ccccggaacc ctctaccaat gccttctgac    600

cttctgaagc tttccgaatc ctcccagttg aggcagtagc tgtgtcctct gagggtggat    660

gggaatcttg ggagaagccc aagcaaggga gccctcagag gtggtgtttg gaccaaagca    720

tcggggtggg ggaggggtct gccgctgtcc cccacctgct ggcccccttg tccttcctca    780

ccccctccaa tatagtctcg gagctacaac cgcagcagcc actataaagg gcaatattga    840

tctttctgtc catgtggctc tatcttttaa aacctcaagg ccctccactg tcctaagata    900

aagcctctca taggcactgg ggaccctgca cagtctggcc atgtgaccct ctccccaggc    960

aagctctgaa gtccctgcag gtggaggcca tgcctgtctt aaactcagtt gcatccctgg   1020

tgcccaaagc aacaccagaa ccaagaagga gctccataaa tccttcttgg gtgaagccta   1080

gacaaagccg ccaggtcttg tggctccagg caccagagcc ttgagtactt tctcctgcct   1140

ccaggcattg gctcagggtg aattacaagg ggctactgaa tggctattac tttcatcacg   1200

actgatcccc acctcctcag ggtcaaaggg ctactttctg gaagtctccc caggctgact   1260

ccttctccct gactgcaagg gctcactccc tcctccaagc tcccacaatg cttcatggct   1320

ctgccgctta cctagcttgg cctagagtgg caaatggaac ttctctgatc tcccccaact   1380

agactggagc ccccgaagga tggagaccat gtctgtgcca tctctgtttc ccctgttttc   1440

ccacatacta ggtgctcaat tcatgcctgt gaatggcgtg agcccataat ggatacacag   1500

aggttgcagc agatggtgtg ggtacctcac ccagatatca tccaggccca aggcccctct   1560

ccctgagtga ggccaggtgt tggcagccaa ctgctccaat ctgcctcctt cccctaaata   1620

ctgccctggt ctagtgggag ctgccttccc cctgccccac ctctcccacc aagaggccac   1680

ctgtcactca tggccaggag agtgacacca tggagggtac aattgccagc tcccccgtgt   1740

ctgtgcagga ttgtctgggt tgaatgacac tctcaaattg ttcctgggat cgggctgagg   1800

ccaggcctct cctggaacca cctctctgct tggtctgacc ccttggccta tccagttttc   1860

ctggttccct cacaggtttc tccagaaagt actccctcag taaagcattt gcacaagaat   1920

ccttgtctca ggctctgctt ctaaggaaag agactgaaga gggacaactt tttcctatga   1980

ggactcccaa tctgccattt gtgtgtggct agctgtttcc agccaggggg ctgaggcacc   2040

tgcagtcacc cacactctgg gcctgtggca ccatctgtgc ctcagctgac tgagcagttc   2100

tgagatgtgg tgactcatgt gaagtggtgt cataggaatg aaggactgtg ggcgctgggt   2160

tcaaattcca gttctatgca ccactccagg tagggatacc catgggggca gctgtgcctg   2220

tgtgggggaa cagggtaggg aaatctccat accttctcaa ttttgctgtg aacctaaaac   2280

tgccatataa agataaagtc taggccaggc atggtggctc atgcctgtaa tcccaacact   2340

tagggtggct gaggcaggca gatcacctgg ggtcaggagt tcaagaccag cctgcccaac   2400

atggcaaaac ctcgtctcta ctaaaaatac aaaaattagc caggcatcgt ggtgggtgcc   2460

tgtaatccca gctattcagg aggctgaggc aggagaatca cttggacctg ggaggcagag   2520

gtttcagtga gcccagatcg cgacactgca ctccagcctg ggcaacagag tgacactctg   2580

tctcaaaaaa taaaataaaa taaaataaaa taaaataaaa taaaataaaa aaaaaaaaaa   2640

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2700

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                 2747


<210>  56
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Glu Leu Ala Leu Leu Cys Gly Leu Val Val Met Ala Gly Val Ile 
1               5                   10                  15


Pro Ile Gln Gly Gly Ile Leu Asn Leu Asn Lys Met Val Lys Gln Val 
            20                  25                  30


Thr Gly Lys Met Pro Ile Leu Ser Tyr Trp Pro Tyr Gly Cys His Cys 
        35                  40                  45


Gly Leu Gly Gly Arg Gly Gln Pro Lys Asp Ala Thr Asp Trp Cys Cys 
    50                  55                  60


Gln Thr His Asp Cys Cys Tyr Asp His Leu Lys Thr Gln Gly Cys Ser 
65                  70                  75                  80


Ile Tyr Lys Asp Tyr Tyr Arg Tyr Asn Phe Ser Gln Gly Asn Ile His 
                85                  90                  95


Cys Ser Asp Lys Gly Ser Trp Cys Glu Gln Gln Leu Cys Ala Cys Asp 
            100                 105                 110


Lys Glu Val Ala Phe Cys Leu Lys Arg Asn Leu Asp Thr Tyr Gln Lys 
        115                 120                 125


Arg Leu Arg Phe Tyr Trp Arg Pro His Cys Arg Gly Gln Thr Pro Gly 
    130                 135                 140


Cys 
145


<210>  57
<211>  2737
<212>  DNA
<213>  Homo sapiens

<400>  57
tgcgaggcag cgtgaagctg gggcctgctc cccgcagcct ctggagcgca tctcagacct     60

tctgagacct atgttgctgg ccccccagaa cccgcaacat ggcagatggg gcaaaggcca    120

accccaaagg gttcaaaaag aaggtgctgg atagatgctt ctctgggtgg aggggcccac    180

gcttcggggc ctcctgtcct tcaagaacct ccaggtctag cctgggtatg aagaagttct    240

tcaccgtggc catccttgct ggcagcgttc tgtccacagc tcacggcagc ctgctcaacc    300

tgaaggccat ggtggaggcc gtcacaggga ggagcgccat cctgtccttc gtgggctacg    360

gttgctactg tgggctgggg ggccgtggcc agcccaagga tgaggtggac tggtgctgcc    420

acgcccacga ctgctgctac caggaactct ttgaccaagg ctgtcacccc tatgtggacc    480

actatgatca caccatcgag aacaacactg agatagtctg cagtgacctc aacaagacag    540

agtgtgacaa gcagacatgc atgtgtgaca agaacatggt tctgtgcctc atgaaccaga    600

cgtaccgaga ggagtaccgt ggcttcctca atgtctactg ccagggcccc acgcccaact    660

gcagcatcta tgaaccgccc cctgaggagg tcacctgcag tcaccaatcc ccagcgcccc    720

ccgcccctcc ctagagcctc tgaggtttga gagagagagc gggaggaggg tctggcttgg    780

ggaccagacg aggtgcaggg agggtaggag ccaggccagg agcctgaggg ttgctggttg    840

cctcctccct ggagctctcc agtgagggct cagctctcag aggactcagg aaggcctggg    900

tcctgactcc cccagcccag ccccaggcat gggtgcctcc tgctgctggt tctggactgg    960

gtgggaggca cggagcttat aggggtctct cctgagggtg gccggggaga cctgagagag   1020

aggaggaggg gcctctgagt ggggcctctg ttgctggcgc cagtttaact ccccggagcc   1080

ttagaaagtc tgagccttag aaagtctggg cctgagcatc caggcccaga gctggatgca   1140

tcctcggccc aagatcacag gaaggcagat tgctggtcac aaagcatggg ttccgggagc   1200

ccctcagctg atcccacagg atggcctggg gtggtggcta ctttgggctt gaagctctct   1260

agagccccat tcacagagca ggtgccccac cccagccctc actgaggtgg ccatgagtcc   1320

aggttcagac cctaggggat gtgcagtgct gagtgtccca gccctgaagt ctagcctcag   1380

agcaggctcc tgggcactga cagagccaca cacccaggta caccccccag gctaatatgg   1440

ggacacacaa aaatatggcc ttcaacacct acaagtcttc tctgtgtccc ccatcgaccc   1500

atgcacatca ccccaaccct gctctgccac accacgtggg tctgaggagc actcctaccc   1560

cccggctccg ggtccctgac agacactgcc ctcctggcct gcacctggaa tggcagccag   1620

aacactggag ggggacccac accctctctc cctgggctgt ggatgggtgt tgcaagtccc   1680

atccctcctg gcctgcacct ggaacagcag ccagaacacc ggagggggac ccacaccctc   1740

tctccctggg ctgtgggcag gcgtcacaag tcccattggt ggggaagagg ctgagggctg   1800

agacccacct cagtgaagag ggaaacgtaa gcagggagag catcaaggcg ggaggcagcc   1860

tggaaacttc tagaagaggg tcaaggtagg aggctacatg gaagcttcta gaaggcagta   1920

aggaacaggg tggtgaagga gaggggagaa gatgggagca tggagagacg aggtgagtga   1980

cagccaccag cagggacggg cctccaggca acacagagga gctgggggcc agggccttac   2040

ggggctgggt tcctgtgtgg ggcgtggagc tggggctgaa gtggagggga cggccctgcg   2100

gcccccagca ctgttgtttc tccaggtgca ccttaccttc ctccttacct gcccgagcct   2160

caactcaggg tcagcagcct ccacggagcc agccccacct gcccgaaaac cactgaagcc   2220

accctccgcc cggactcaac agccgccagc aagctcgcct ggcagtgccc ctggagcacc   2280

attgtcgctg gggagggaga gccgggaagg gtggagaagg aggcagaagg gacatgtatg   2340

aaaaaaggac aggaaacctg accagaggcg gtttccagag ccccagcctt ggagacaagg   2400

acactgccac ccagcgccac agtcagtctg ggaggggccc acgcccccca ccccccatgc   2460

cacactgccg cctcttgctg gccatggttc tccggcttgg gggaacgcag gttcccagct   2520

gcgcccctcc cccgcgcaca cacaccctcc cctgtccctc ggaaagacta ggccagggtc   2580

tggggatggg attctgctgc caggggtcct gcctgccccc actcacccca gacgcttcgg   2640

atgctgcagc tcctggataa tctccacagg actcggcttc ctctcctcaa atgaataaag   2700

gcctcctacc tcaactccca aaaaaaaaaa aaaaaaa                            2737


<210>  58
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ala Asp Gly Ala Lys Ala Asn Pro Lys Gly Phe Lys Lys Lys Val 
1               5                   10                  15


Leu Asp Arg Cys Phe Ser Gly Trp Arg Gly Pro Arg Phe Gly Ala Ser 
            20                  25                  30


Cys Pro Ser Arg Thr Ser Arg Ser Ser Leu Gly Met Lys Lys Phe Phe 
        35                  40                  45


Thr Val Ala Ile Leu Ala Gly Ser Val Leu Ser Thr Ala His Gly Ser 
    50                  55                  60


Leu Leu Asn Leu Lys Ala Met Val Glu Ala Val Thr Gly Arg Ser Ala 
65                  70                  75                  80


Ile Leu Ser Phe Val Gly Tyr Gly Cys Tyr Cys Gly Leu Gly Gly Arg 
                85                  90                  95


Gly Gln Pro Lys Asp Glu Val Asp Trp Cys Cys His Ala His Asp Cys 
            100                 105                 110


Cys Tyr Gln Glu Leu Phe Asp Gln Gly Cys His Pro Tyr Val Asp His 
        115                 120                 125


Tyr Asp His Thr Ile Glu Asn Asn Thr Glu Ile Val Cys Ser Asp Leu 
    130                 135                 140


Asn Lys Thr Glu Cys Asp Lys Gln Thr Cys Met Cys Asp Lys Asn Met 
145                 150                 155                 160


Val Leu Cys Leu Met Asn Gln Thr Tyr Arg Glu Glu Tyr Arg Gly Phe 
                165                 170                 175


Leu Asn Val Tyr Cys Gln Gly Pro Thr Pro Asn Cys Ser Ile Tyr Glu 
            180                 185                 190


Pro Pro Pro Glu Glu Val Thr Cys Ser His Gln Ser Pro Ala Pro Pro 
        195                 200                 205


Ala Pro Pro 
    210


<210>  59
<211>  1623
<212>  DNA
<213>  Homo sapiens

<400>  59
gtgcgcggtg ctccgtggct gcgctgctgg aacccgctgg aagagataca ggtttgctct     60

ggagcagcag cagctggcgg agcaatggag atgcaatcct attatgccaa gcttttgggg    120

gagctgaatg aacagagaaa gagggacttt ttctgtgact gcagcatcat tgtggaaggg    180

cggatcttca aggcccacag gaacattttg tttgctaaca gcggctactt ccgagccctg    240

ctcattcact atatccagga cagcgggcgg catagcaccg cctccttgga cattgtcacc    300

tctgatgcct tctccatcat cttagatttc ctctattctg ggaagttgga tttgtgtggg    360

gagaatgtga ttgaagtgat gtcggctgcc agctacctgc agatgaatga cgtggtgaac    420

ttctgcaaga catacattag gtcatccctc gacatttgcc gaaagatgga gaaggaggct    480

gctgtggctg cagcagtggc ggcggcagcg gcggcggctg cagcggcggc agcagcggcg    540

gctcatcagg ttgacagtga aagccccagt tcaggccggg aggggacctc ctgtggtacc    600

aagagcttgg tctcctctcc agccgaggga gaaaagagcg tggagtgcct gagagagtcc    660

ccttgcggtg actgcggaga ctgccacccc ttggaactgg tggtgagaga cagccttggc    720

ggtggctcgg ctgacagcaa cctctctact ccacccaaac ggatagagcc caaggtggaa    780

tttgatgctg atgaagtgga ggtggacgtt ggtgaacagc tgcagcagta tgctgccccg    840

ctgaacctgg cccacgtgga ggaggccttg ccaagcggcc aggcggttga cttggcttac    900

agcaactacc acgtgaagca gttcctggag gcgctcttgc gcaacagcgc tgccccgagc    960

aaggatgatg cagaccatca cttttctagg agtttggaag gaagaccaga aggtgcagga   1020

gtagccatga gttccatgat ggatgtccag gctgactggt atggagagga ctcaggtgat   1080

gtgctggtgg tccccatcaa gctccacaag tgtcctttct gcccttacac tgccaaacag   1140

aagggcatcc tcaagcggca catccgttca cacacaggcg agcggcccta cccctgtgag   1200

acctgcggca agaggttcac tcgacaagag cacctgcgga gccacgcact gagtgtccac   1260

agatccaacc gtccaatcat ctgcaagggc tgcaggagaa cattcacgag tcacctgtcc   1320

caggggctgc ggcgcttcgg gctgtgtgac agctgcacct gcgttacaga cacacccgat   1380

gatgatgatg atttgatgcc catcaacctt agcttggtgg aggcttcatc tgaaagccaa   1440

gaaaagagcg acacagacaa tgactggcca atctatgtgg agtcggagat cgggtctcat   1500

tatgttgccc aggctagtct ggaactcctg gccttaagcc aacctcctgc ctcagcctcc   1560

caaagtgctg gcattacaga cggagtctca ctctgttgcc caggccggag tacagtggca   1620

tga                                                                 1623


<210>  60
<211>  512
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Glu Met Gln Ser Tyr Tyr Ala Lys Leu Leu Gly Glu Leu Asn Glu 
1               5                   10                  15


Gln Arg Lys Arg Asp Phe Phe Cys Asp Cys Ser Ile Ile Val Glu Gly 
            20                  25                  30


Arg Ile Phe Lys Ala His Arg Asn Ile Leu Phe Ala Asn Ser Gly Tyr 
        35                  40                  45


Phe Arg Ala Leu Leu Ile His Tyr Ile Gln Asp Ser Gly Arg His Ser 
    50                  55                  60


Thr Ala Ser Leu Asp Ile Val Thr Ser Asp Ala Phe Ser Ile Ile Leu 
65                  70                  75                  80


Asp Phe Leu Tyr Ser Gly Lys Leu Asp Leu Cys Gly Glu Asn Val Ile 
                85                  90                  95


Glu Val Met Ser Ala Ala Ser Tyr Leu Gln Met Asn Asp Val Val Asn 
            100                 105                 110


Phe Cys Lys Thr Tyr Ile Arg Ser Ser Leu Asp Ile Cys Arg Lys Met 
        115                 120                 125


Glu Lys Glu Ala Ala Val Ala Ala Ala Val Ala Ala Ala Ala Ala Ala 
    130                 135                 140


Ala Ala Ala Ala Ala Ala Ala Ala Ala His Gln Val Asp Ser Glu Ser 
145                 150                 155                 160


Pro Ser Ser Gly Arg Glu Gly Thr Ser Cys Gly Thr Lys Ser Leu Val 
                165                 170                 175


Ser Ser Pro Ala Glu Gly Glu Lys Ser Val Glu Cys Leu Arg Glu Ser 
            180                 185                 190


Pro Cys Gly Asp Cys Gly Asp Cys His Pro Leu Glu Leu Val Val Arg 
        195                 200                 205


Asp Ser Leu Gly Gly Gly Ser Ala Asp Ser Asn Leu Ser Thr Pro Pro 
    210                 215                 220


Lys Arg Ile Glu Pro Lys Val Glu Phe Asp Ala Asp Glu Val Glu Val 
225                 230                 235                 240


Asp Val Gly Glu Gln Leu Gln Gln Tyr Ala Ala Pro Leu Asn Leu Ala 
                245                 250                 255


His Val Glu Glu Ala Leu Pro Ser Gly Gln Ala Val Asp Leu Ala Tyr 
            260                 265                 270


Ser Asn Tyr His Val Lys Gln Phe Leu Glu Ala Leu Leu Arg Asn Ser 
        275                 280                 285


Ala Ala Pro Ser Lys Asp Asp Ala Asp His His Phe Ser Arg Ser Leu 
    290                 295                 300


Glu Gly Arg Pro Glu Gly Ala Gly Val Ala Met Ser Ser Met Met Asp 
305                 310                 315                 320


Val Gln Ala Asp Trp Tyr Gly Glu Asp Ser Gly Asp Val Leu Val Val 
                325                 330                 335


Pro Ile Lys Leu His Lys Cys Pro Phe Cys Pro Tyr Thr Ala Lys Gln 
            340                 345                 350


Lys Gly Ile Leu Lys Arg His Ile Arg Ser His Thr Gly Glu Arg Pro 
        355                 360                 365


Tyr Pro Cys Glu Thr Cys Gly Lys Arg Phe Thr Arg Gln Glu His Leu 
    370                 375                 380


Arg Ser His Ala Leu Ser Val His Arg Ser Asn Arg Pro Ile Ile Cys 
385                 390                 395                 400


Lys Gly Cys Arg Arg Thr Phe Thr Ser His Leu Ser Gln Gly Leu Arg 
                405                 410                 415


Arg Phe Gly Leu Cys Asp Ser Cys Thr Cys Val Thr Asp Thr Pro Asp 
            420                 425                 430


Asp Asp Asp Asp Leu Met Pro Ile Asn Leu Ser Leu Val Glu Ala Ser 
        435                 440                 445


Ser Glu Ser Gln Glu Lys Ser Asp Thr Asp Asn Asp Trp Pro Ile Tyr 
    450                 455                 460


Val Glu Ser Glu Ile Gly Ser His Tyr Val Ala Gln Ala Ser Leu Glu 
465                 470                 475                 480


Leu Leu Ala Leu Ser Gln Pro Pro Ala Ser Ala Ser Gln Ser Ala Gly 
                485                 490                 495


Ile Thr Asp Gly Val Ser Leu Cys Cys Pro Gly Arg Ser Thr Val Ala 
            500                 505                 510


<210>  61
<211>  7333
<212>  DNA
<213>  Homo sapiens

<400>  61
agaaatccag cccttctgcc ctccggaggc gcctttccca acgtaaagta caattttaaa     60

tttcagctcc tgactaaaat catgatccgc agtcaactgc tagagaatct gggcaccccg    120

gtgtctctgg agcgtgcagc gagtgtgggc aagggcaggg ggagtgggcg aagctgctgg    180

ttggtgcctg aaatctgtgc gttgcccctt taattgtgtc cccagccctc gggcgtttct    240

gtccaacgcc cacgtcagca aatacctttt gtttctctca cgttggggct acttgtttta    300

gggcgcaaag gaacggcctc gaaagggggt ccttccccag ccgagaacca ggaatcttcc    360

ctcggcccgc gcgcgcgacc ggccggtgcg ccgcggcccg cggacaatcc tccaaacaca    420

gactgtttga cttagaatct tccctttttt actccattca agagcagcat tcataaattt    480

ccagaatgga gatctcctct catcagtctc acctcctgca gcaactgaac gagcagcgca    540

ggcaagatgt attttgtgac tgcagtattc tagttgaagg gaaggtcttc aaagcacatc    600

gaaatgtatt attcgctagt agcggctact ttaaaatgct tctttctcag aattcaaagg    660

agacgagtca gccaaccaca gctacatttc aggctttctc ccctgacact tttacagtta    720

tcttggactt cgtatattct ggcaaactgt ctcttactgg tcagaatgtc atagaagtga    780

tgtcggctgc tagcttcctt cagatgactg atgtcataag tgtatgtaag acttttatta    840

aatcttcctt agacattagt gagaaagaaa aagatcgcta tttcagtctc tcagataaag    900

atgccaattc taatggtgta gaacgttcct ctttttatag tggtggctgg caagaaggaa    960

gcagttctcc acgttctcac ctaagcccag agcaaggaac aggtataata agtggaaaat   1020

cttggaataa gtataattat catccagcct cccagaagaa tactcaacaa cccttggcca   1080

agcatgaacc aaggaaagag tccattaaaa agaccaaaca tttgagattg tcacagcctt   1140

ctgaagttac tcattataag tcaagcaaac gagaagtacg aacatctgat tcttccagcc   1200

atgtttccca gtctgaagaa caagcacaga ttgatgctga aatggactct actcctgttg   1260

gctatcagta cggtcaagga tctgatgtca catccaaaag ctttccagat gatctgcctc   1320

ggatgcgatt caagtgcccg tactgcacac atgtggtgaa gcggaaggca gacctaaagc   1380

gccaccttcg ttgtcataca ggagaaaggc cctatccatg tcaagcttgt ggaaaaagat   1440

ttagcaggct agaccatcta agtagccatt ttcgaacaat tcaccaggca tgtaaactca   1500

tctgcagaaa atgtaaacgt catgtgacag atctaacagg gcaagtggta caggagggaa   1560

ccaggcgcta cagactgtgt aatgagtgtc ttgcagaatt tggcatagac agcctcccca   1620

ttgacttgga agctgaacaa catcttatgt ccccatcaga tggagataag gattccagat   1680

ggcacttgag tgaagatgag aatagatcct atgtggagat tgtagaagat gggtctggtg   1740

atctggtcat ccaacaggtt gatgatagtg aagaagaaga agaaaaagaa attaagccca   1800

acattaggta gctgtaatgt gaaccaacag agctggcatg tctgcaattt acattgactt   1860

cctgtatctc tctctttcta tggtcggagt ctagttaaca aatttatcac actgacttta   1920

aagaaatgat ctgatataac ttgcatgctt tctgaacagg ccattgtatc cattctgaac   1980

tttgttgccc taaaatgtgt tgctgcactg gaaagaaaga actagcttga gttggcttga   2040

tggatgaaca attatcctct tactttcatt acaatcctct tactttattc cagagatacc   2100

tttttctttt aatattggag gatctactta gcaaactttt ttcaaagaaa atactttaaa   2160

taaattcacc acaaccaaac tttatgtaag acaatttcaa ggtgtttcaa aaacacataa   2220

ctaccaatgt ttaatttcac agggaaccag ttaagagcac atttaaggat ctggcaaccc   2280

accttactaa acaaattagt ctttctatta atttgagatc tgaaacaacc tgtcattact   2340

ctgatatcct gaacgtttaa ggattatgga agaagactaa agtgtttgaa atcattcata   2400

tttgaaattt ttatcattag cttaaaaatt actctcagta ttgttaaaaa aaaaaaaaag   2460

tagaggctgg ccaaagatta tatacagata ttttcttaaa gcaggaaact aatgttgcct   2520

aaaagtcaag gtagtttgtg aagacaatct gtcaatatgg ttgtccatct ctctaaagaa   2580

aagcaggctg ggcgctgtgg ctcatgccta taatcccaat actttgggag gccgaggcag   2640

gcggatcaca aggtcaggag tttgaaacca gcctggccaa catggtgaaa cctcgtctct   2700

actaaaaaat acaaaattag ccgggcatgg tggcgggtgc ctataatccc agctactcgg   2760

gaggctgagg caggagaatc gattgaacct ggaaggcaga agttgcagtg agccgagatc   2820

acaccattgc actccagcct gggcaacaag agcgaaactc cgtctcaaaa aaaaaaggaa   2880

aacaaactag gaggttctta ccatatgtga gtgatttcta acgtttatgt agtgctatat   2940

tatttataaa gtactctctc atgtattttc tcagtgaggt ggatactatc tccgatttac   3000

aaatgaggaa attaaggtca gaaagtctga gagagaaaac tgatgattgg acaggatctg   3060

attttaaaca atcctctttc agccttctct ccctgtatgt ctcctgaaat ggcaaagaat   3120

agaagtcaaa cctcaccagt tggcagtcat tataaaaata agccaatcag aattagaaag   3180

tatgaaagga ggaattgaat cattttcaac aacatacaat atcttgatct agagattttc   3240

aaataatgct aagtaatgtc cctacagtac ctattggtat gtttttatgt cacgttattt   3300

atatgtaaat ttaaagtata aaactatttg aacaaattat tcacttaaat atgttgaaca   3360

tttttgcttc tcttgtttat ataatatttt caaaacaaac ttttctccta gtatacaaag   3420

tttaaacttc tcccctttgg gctgggccca gtggctcacg cctgtaatcc cagcactttg   3480

ggaggctgag gcaggtggat caccgaggtc gggagtttga gaccagcctg accaacatgg   3540

agaaaccccg tctctactaa aaatacaaaa ttagccgggc gtggtggtgc atgcctgtaa   3600

tcccagctac tcagaaggct gaggcaggag gatagcttga acccaggagg cagaggctgc   3660

ggtgggctga ggttgcgcca ttgcactcca gcctgggcaa caagagcgaa actccgtctc   3720

aaaaaaaaaa aaaaaaaaaa cttctcccct gcataaatta tgaaacattc caaaattaca   3780

gctaaattag agaagcattg tttcagttct aaaggtaaaa tctaaatatc cgaagtaaag   3840

aactgagctt cataaaggtc tcttctgcaa gttatcacag tgaagcttga tagaatttca   3900

ctgtatatgg agaggctcca tctattttac tgttttcttt tttgtttttg tttttttttc   3960

gagacggagt ctcgctctgt cgcccaggct ggagtgcagt ggtgcaatct cagctcactg   4020

caagctccac ctcccgggtt ctcgccattc tcctgcctca gcctcccgag tagctgggac   4080

ttacaggcgc ccaccaccac tcccagctaa ttttttgtat ttttaataga gatggggttt   4140

caccgtgtta gccaggatgg tctcaatctc ctgatctcgt gatccgcccc cctcggcctc   4200

ccaaagtgct gggattacag gcgtgagcca ctgcgcccag ccaattttac tgtattttta   4260

aatgccatga catacctcaa aattatcctt tttatgttac tattttctct tgttctttca   4320

ttaattattg tccttgatac caatttctag gctaaattgg ttactttctt ttaaaaaatt   4380

taaaaataga tgaataacca cttgtttcat ggtacttaat tgagactttt tcaagattcc   4440

cctgatggca catttgcagt tgcttcaaga ctggatgatg tgcattgagt tctctgttct   4500

cccaacatgg ctgttcctaa atcaggattc tggttttttt gagatggact ctcgctctgt   4560

tgtccaagct ggagtgcagt ggcgtgatct cgctcaccac aacctctgcc tcccgggttc   4620

aagcgattct cctgcctcag cctcctgagt agccgggact acaggcatgt gccaccatgc   4680

ctggctaatt tttgtatttt tagtagagac agggtttcgc tatgttggcc aggctggtct   4740

cgaactcctg acctcgtgat ctgcccgcct cagcctccca aagtgctggg attacaggcg   4800

tgagccagca cgcccggcct aaatcaggat tcttaacaat taaagtgtat ctgaatgagg   4860

aaggaaacgc ttgtcattct ctagtcttac ccaattaata ctgacacctt ttgaaattaa   4920

aacctgattt tttagttgtt ggagccagta ggaaaaatgg ctgatttgaa cttttttcct   4980

ataaatgaag tagtgcttgc atgtgtgtac tctaatgcac tttagtctat gatctaaatg   5040

tccttttatg ctattatctt ctgcatgcaa actttacata catcagcatg aatatccaac   5100

attcactgaa cacagtgcca ccagcacttg taattgcctt ttcagaaata atgctttctc   5160

ataattgttt ataacgagca tcaaactatc cccacaaaat gatcaagttc accaaactag   5220

acaaagaatc tgttgtatca ttttaacatc atagaagaac atttaagaca tgtttgtaag   5280

ttgtaaataa tgactccagt tatagcatat atatctaaga cgttagagac cagttatttt   5340

ctagagtgaa actgtctatt gatgattgag aaaattgaat tctttggttt ttacatgtgg   5400

gcaaatgtta cataggggta taatctgttt aaataagctt tatttatgcc aaggattttt   5460

tttttaatat caagacttgg ttagaccaaa gtttgctctt gcaggaatgc catttatcag   5520

cttctgaatg cccttctaac tccattaccc tcaagagtgt ctgggtatag gatgaagcat   5580

tacaaaaaga aagcaccact gcagtcatgc ctagtgtctg ggagaaacaa aatggactag   5640

acctgcagtt taaaataatt taacccgaga aactcttcaa atgaattgtt tcctaaagat   5700

gctcaaattt aagggataaa ctctaaaatc agagctgctg tggttaaagt cccccacaaa   5760

cctttcccca gacacctctg cagaactcag gtgcacaatg ttgaaaacca tggaattaga   5820

caacttcctg aattcccttt gagccttgca gcctcatttc gttactcctg ttactcacgg   5880

tgcttataag caggtaacca tatggtctct tagtgaagca aatcacatcc ttagcacatg   5940

atgttccttc tatgggtatc agatcttaag actttttaaa atttaggaac aaatgtttca   6000

atattatatt ttcagtaatg caatcaaaat aagcatagtt actgttttct gtacggctaa   6060

gtactgccta atggatgaaa gaagtttggt gcttcaatta tttatgagct cagaactcaa   6120

ttcattaaag ttattttgcc aagtcatgcc aagatatatt gaaatttcca ctcatattgg   6180

tttttaaaat tttttttagt cctaaaatta ataagtatgg aaaatcacta aaagcagtgt   6240

aggataaggt gtgtttaact ggccgggcac ggtggctcat gcctgtaatc ctagcacttt   6300

gggaggccga ggcgggcgga tcacttaagg ccaggtgttc gagaccatcc tggccaacat   6360

ggtgaaaccc cgtctctagt aaaaatacaa aaaatagctg ggcatgatgg tgggtgcctg   6420

taatcccagg tactcgggag gctgaggcag gagaatcgct tgaacccggg aggtggaggt   6480

tgcagtggcc gagatcgcac cactgcactc cagcctgggt gacagagcga gactccatca   6540

aaaaaaaaaa aaaaaaaaaa aaagatgtgt ttaactggga agggtgataa taatagaata   6600

ataggtacag gaggaccaaa ctttagatta taaaccagaa agttttgtta ttttatataa   6660

gtgtatcagt attactattt atcatttata tagcatttta tatttgcaaa gtgtttaata   6720

atttttgtta ttctttacat atatatgaaa taggacagtt atcccacatg aacggtaaat   6780

aaattgaggc acagaacagt aaaaaaacct cagggtcagg cgtggtggct cacacctgta   6840

atcccagcac tttgggaggc caaggcgggt ggatcacttt aggtcaagag ttggagacca   6900

gcctggggca atatagtgaa accccttctc tactaaaaat acaaaaatta gccaggcatg   6960

gtggtgggca cctgtaatcc cagctactct gggggctgag acaggagaat tgcttgaact   7020

caggaggcgg aggttgcagt gagccaagat cacgctactg cactccaggc tgggtgacag   7080

agcgagactc cacctcaaaa aaaaaaaaaa aaaaaaaaaa aagaacctaa gacaacccag   7140

tgaaatggta gcaaaaaata ggaaatataa tgatcacatt ttctgaatcc tagaccatca   7200

gcctaattca ctgaggtgtg ttgtgtatca ctctatttta tagatgattt tatataagta   7260

acagtggatt gttttaaagc tgacgtcatt gtatgtggat acattctata tggaataaat   7320

gttatgtaaa gga                                                      7333


<210>  62
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Glu Ile Ser Ser His Gln Ser His Leu Leu Gln Gln Leu Asn Glu 
1               5                   10                  15


Gln Arg Arg Gln Asp Val Phe Cys Asp Cys Ser Ile Leu Val Glu Gly 
            20                  25                  30


Lys Val Phe Lys Ala His Arg Asn Val Leu Phe Ala Ser Ser Gly Tyr 
        35                  40                  45


Phe Lys Met Leu Leu Ser Gln Asn Ser Lys Glu Thr Ser Gln Pro Thr 
    50                  55                  60


Thr Ala Thr Phe Gln Ala Phe Ser Pro Asp Thr Phe Thr Val Ile Leu 
65                  70                  75                  80


Asp Phe Val Tyr Ser Gly Lys Leu Ser Leu Thr Gly Gln Asn Val Ile 
                85                  90                  95


Glu Val Met Ser Ala Ala Ser Phe Leu Gln Met Thr Asp Val Ile Ser 
            100                 105                 110


Val Cys Lys Thr Phe Ile Lys Ser Ser Leu Asp Ile Ser Glu Lys Glu 
        115                 120                 125


Lys Asp Arg Tyr Phe Ser Leu Ser Asp Lys Asp Ala Asn Ser Asn Gly 
    130                 135                 140


Val Glu Arg Ser Ser Phe Tyr Ser Gly Gly Trp Gln Glu Gly Ser Ser 
145                 150                 155                 160


Ser Pro Arg Ser His Leu Ser Pro Glu Gln Gly Thr Gly Ile Ile Ser 
                165                 170                 175


Gly Lys Ser Trp Asn Lys Tyr Asn Tyr His Pro Ala Ser Gln Lys Asn 
            180                 185                 190


Thr Gln Gln Pro Leu Ala Lys His Glu Pro Arg Lys Glu Ser Ile Lys 
        195                 200                 205


Lys Thr Lys His Leu Arg Leu Ser Gln Pro Ser Glu Val Thr His Tyr 
    210                 215                 220


Lys Ser Ser Lys Arg Glu Val Arg Thr Ser Asp Ser Ser Ser His Val 
225                 230                 235                 240


Ser Gln Ser Glu Glu Gln Ala Gln Ile Asp Ala Glu Met Asp Ser Thr 
                245                 250                 255


Pro Val Gly Tyr Gln Tyr Gly Gln Gly Ser Asp Val Thr Ser Lys Ser 
            260                 265                 270


Phe Pro Asp Asp Leu Pro Arg Met Arg Phe Lys Cys Pro Tyr Cys Thr 
        275                 280                 285


His Val Val Lys Arg Lys Ala Asp Leu Lys Arg His Leu Arg Cys His 
    290                 295                 300


Thr Gly Glu Arg Pro Tyr Pro Cys Gln Ala Cys Gly Lys Arg Phe Ser 
305                 310                 315                 320


Arg Leu Asp His Leu Ser Ser His Phe Arg Thr Ile His Gln Ala Cys 
                325                 330                 335


Lys Leu Ile Cys Arg Lys Cys Lys Arg His Val Thr Asp Leu Thr Gly 
            340                 345                 350


Gln Val Val Gln Glu Gly Thr Arg Arg Tyr Arg Leu Cys Asn Glu Cys 
        355                 360                 365


Leu Ala Glu Phe Gly Ile Asp Ser Leu Pro Ile Asp Leu Glu Ala Glu 
    370                 375                 380


Gln His Leu Met Ser Pro Ser Asp Gly Asp Lys Asp Ser Arg Trp His 
385                 390                 395                 400


Leu Ser Glu Asp Glu Asn Arg Ser Tyr Val Glu Ile Val Glu Asp Gly 
                405                 410                 415


Ser Gly Asp Leu Val Ile Gln Gln Val Asp Asp Ser Glu Glu Glu Glu 
            420                 425                 430


Glu Lys Glu Ile Lys Pro Asn Ile Arg 
        435                 440


<210>  63
<211>  717
<212>  DNA
<213>  Homo sapiens

<400>  63
ccgggccgaa gtccggtgga tgaagggcgg aagtagagtg tctaatcctg cagtcatggc     60

gcaggaagag gaagatgtta gagattacaa tttgactgaa gaacagaagg cgatcaaggc    120

caagtatccg ccagtcaata ggaagtacga gtatttggat catacagcag atgtccagtt    180

acacgcatgg ggagatactc tggaggaagc atttgagcaa tgtgcaatgg ccatgtttgg    240

ttacatgaca gatactggga cagtggagcc cctccaaaca gtagaagtag aaacccaagg    300

agatgactta cagtctcttc tgtttcactt tttggatgaa tggctttata agttcagtgc    360

tgatgaattc ttcatacccc gggaagtgaa agtacttagc attgatcaaa gaaatttcaa    420

attacgatca attgggtggg gagaagaatt ttcattgtcc aagcaccctc agggaacaga    480

agtcaaagca ataacatatt cagcaatgca ggtctataat gaagagaacc cggaagtttt    540

tgtgatcatt gacatttaag acaccaaaaa ataaaagact cctacgaaga actgtttttg    600

ttttcctctt ccttttgaga agacactatg aattaaattc tacagctttt ttttgatata    660

tggaaatttg tagaacagaa atattttagt taaagtgtga ctttcagaaa gggaaaa       717


<210>  64
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Lys Gly Gly Ser Arg Val Ser Asn Pro Ala Val Met Ala Gln Glu 
1               5                   10                  15


Glu Glu Asp Val Arg Asp Tyr Asn Leu Thr Glu Glu Gln Lys Ala Ile 
            20                  25                  30


Lys Ala Lys Tyr Pro Pro Val Asn Arg Lys Tyr Glu Tyr Leu Asp His 
        35                  40                  45


Thr Ala Asp Val Gln Leu His Ala Trp Gly Asp Thr Leu Glu Glu Ala 
    50                  55                  60


Phe Glu Gln Cys Ala Met Ala Met Phe Gly Tyr Met Thr Asp Thr Gly 
65                  70                  75                  80


Thr Val Glu Pro Leu Gln Thr Val Glu Val Glu Thr Gln Gly Asp Asp 
                85                  90                  95


Leu Gln Ser Leu Leu Phe His Phe Leu Asp Glu Trp Leu Tyr Lys Phe 
            100                 105                 110


Ser Ala Asp Glu Phe Phe Ile Pro Arg Glu Val Lys Val Leu Ser Ile 
        115                 120                 125


Asp Gln Arg Asn Phe Lys Leu Arg Ser Ile Gly Trp Gly Glu Glu Phe 
    130                 135                 140


Ser Leu Ser Lys His Pro Gln Gly Thr Glu Val Lys Ala Ile Thr Tyr 
145                 150                 155                 160


Ser Ala Met Gln Val Tyr Asn Glu Glu Asn Pro Glu Val Phe Val Ile 
                165                 170                 175


Ile Asp Ile 



<210>  65
<211>  2314
<212>  DNA
<213>  Homo sapiens

<400>  65
cgcgcgcaca gagcgagctc ttgcagcctc cccgcccctc ccgcaacgct cgaccccagg     60

attcccccgg ctcgcctgcc cgccatggcc gacaaggaag cagccttcga cgacgcagtg    120

gaagaacgag tgatcaacga ggaatacaaa atatggaaaa agaacacccc ttttctttat    180

gatttggtga tgacccatgc tctggagtgg cccagcctaa ctgcccagtg gcttccagat    240

gtaaccagac cagaagggaa agatttcagc attcatcgac ttgtcctggg gacacacaca    300

tcggatgaac aaaaccatct tgttatagcc agtgtgcagc tccctaatga tgatgctcag    360

tttgatgcgt cacactacga cagtgagaaa ggagaatttg gaggttttgg ttcagttagt    420

ggaaaaattg aaatagaaat caagatcaac catgaaggag aagtaaacag ggcccgttat    480

atgccccaga acccttgtat catcgcaaca aagactcctt ccagtgatgt tcttgtcttt    540

gactatacaa aacatccttc taaaccagat ccttctggag agtgcaaccc agacttgcgt    600

ctccgtggac atcagaagga aggctatggg ctttcttgga acccaaatct cagtgggcac    660

ttacttagtg cttcagatga ccataccatc tgcctgtggg acatcagtgc cgttccaaag    720

gagggaaaag tggtagatgc gaagaccatc tttacagggc atacggcagt agtagaagat    780

gtttcctggc atctactcca tgagtctctg tttgggtcag ttgctgatga tcagaaactt    840

atgatttggg atactcgttc aaacaatact tccaaaccaa gccactcagt tgatgctcac    900

actgctgaag tgaactgcct ttctttcaat ccttatagtg agttcattct tgccacagga    960

tcagctgaca agactgttgc cttgtgggat ctgagaaatc tgaaacttaa gttgcattcc   1020

tttgagtcac ataaggatga aatattccag gttcagtggt cacctcacaa tgagactatt   1080

ttagcttcca gtggtactga tcgcagactg aatgtctggg atttaagtaa aattggagag   1140

gaacaatccc cagaagatgc agaagacggg ccaccagagt tgttgtttat tcatggtggt   1200

catactgcca agatatctga tttctcctgg aatcccaatg aaccttgggt gatttgttct   1260

gtatcagaag acaatatcat gcaagtgtgg caaatggcag agaacattta taatgatgaa   1320

gaccctgaag gaagcgtgga tccagaagga caagggtcct agatatgtct ttacttgttg   1380

tgattttaga ctcccctttt ttcttctcaa ccctgagagt gatttaacac tggttttgag   1440

acagacttta ttcagctatc cctctatata ataggtacca ccgataatgc tattagccca   1500

aaccgtgggt ttttctaaat attaataggg gggcttgatt caacaaagcc acagacttaa   1560

cgttgaaatt ttcttcagga attttctagt aacccaggtc taaagtagct acagaaaggg   1620

gaatattatg tgtgattatt tttcttctta tgctatatcc ccaagttttt cagactcatt   1680

taagtaaagg ctagagtgag taaggaatag agccaaatga ggtaggtgtc tgagccatga   1740

agtataaata ctgaaagatg tcacttttat tcaggaaata gggggagttc aagtcgtata   1800

gattcctact cgaaaatctt gacacctgac tttccaggat gcacattttc atacgtagac   1860

cagtttcctc ttggtttctt cagttaagtc aaaacaacac gttcctcttt ccccatatat   1920

tcatatattt ttgctcgtta gtgtatttct tgagctgttt tcatgttgtt tatttcctgt   1980

ctgtgaaatg gtgttttttt ttttgttgtt ggtttttttt tttttttttt aacttgggac   2040

caccaagttg taaagatgta tgtttttacc tgacagttat accacaggta gactgtcaag   2100

ttgagaagag tgaatcaata acttgtattt gttttaaaaa ttaaattaat ccttgataag   2160

agttgctttt tttttttagg agttagtcct tgaccactag tttgatgcca tctccatttt   2220

gggtgacctg tttcaccagc aggcctgtta ctctccatga ctaactgtgt aagtgcttaa   2280

aatggaataa attgcttttc tacataaaaa aaaa                               2314


<210>  66
<211>  425
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Ala Asp Lys Glu Ala Ala Phe Asp Asp Ala Val Glu Glu Arg Val 
1               5                   10                  15


Ile Asn Glu Glu Tyr Lys Ile Trp Lys Lys Asn Thr Pro Phe Leu Tyr 
            20                  25                  30


Asp Leu Val Met Thr His Ala Leu Glu Trp Pro Ser Leu Thr Ala Gln 
        35                  40                  45


Trp Leu Pro Asp Val Thr Arg Pro Glu Gly Lys Asp Phe Ser Ile His 
    50                  55                  60


Arg Leu Val Leu Gly Thr His Thr Ser Asp Glu Gln Asn His Leu Val 
65                  70                  75                  80


Ile Ala Ser Val Gln Leu Pro Asn Asp Asp Ala Gln Phe Asp Ala Ser 
                85                  90                  95


His Tyr Asp Ser Glu Lys Gly Glu Phe Gly Gly Phe Gly Ser Val Ser 
            100                 105                 110


Gly Lys Ile Glu Ile Glu Ile Lys Ile Asn His Glu Gly Glu Val Asn 
        115                 120                 125


Arg Ala Arg Tyr Met Pro Gln Asn Pro Cys Ile Ile Ala Thr Lys Thr 
    130                 135                 140


Pro Ser Ser Asp Val Leu Val Phe Asp Tyr Thr Lys His Pro Ser Lys 
145                 150                 155                 160


Pro Asp Pro Ser Gly Glu Cys Asn Pro Asp Leu Arg Leu Arg Gly His 
                165                 170                 175


Gln Lys Glu Gly Tyr Gly Leu Ser Trp Asn Pro Asn Leu Ser Gly His 
            180                 185                 190


Leu Leu Ser Ala Ser Asp Asp His Thr Ile Cys Leu Trp Asp Ile Ser 
        195                 200                 205


Ala Val Pro Lys Glu Gly Lys Val Val Asp Ala Lys Thr Ile Phe Thr 
    210                 215                 220


Gly His Thr Ala Val Val Glu Asp Val Ser Trp His Leu Leu His Glu 
225                 230                 235                 240


Ser Leu Phe Gly Ser Val Ala Asp Asp Gln Lys Leu Met Ile Trp Asp 
                245                 250                 255


Thr Arg Ser Asn Asn Thr Ser Lys Pro Ser His Ser Val Asp Ala His 
            260                 265                 270


Thr Ala Glu Val Asn Cys Leu Ser Phe Asn Pro Tyr Ser Glu Phe Ile 
        275                 280                 285


Leu Ala Thr Gly Ser Ala Asp Lys Thr Val Ala Leu Trp Asp Leu Arg 
    290                 295                 300


Asn Leu Lys Leu Lys Leu His Ser Phe Glu Ser His Lys Asp Glu Ile 
305                 310                 315                 320


Phe Gln Val Gln Trp Ser Pro His Asn Glu Thr Ile Leu Ala Ser Ser 
                325                 330                 335


Gly Thr Asp Arg Arg Leu Asn Val Trp Asp Leu Ser Lys Ile Gly Glu 
            340                 345                 350


Glu Gln Ser Pro Glu Asp Ala Glu Asp Gly Pro Pro Glu Leu Leu Phe 
        355                 360                 365


Ile His Gly Gly His Thr Ala Lys Ile Ser Asp Phe Ser Trp Asn Pro 
    370                 375                 380


Asn Glu Pro Trp Val Ile Cys Ser Val Ser Glu Asp Asn Ile Met Gln 
385                 390                 395                 400


Val Trp Gln Met Ala Glu Asn Ile Tyr Asn Asp Glu Asp Pro Glu Gly 
                405                 410                 415


Ser Val Asp Pro Glu Gly Gln Gly Ser 
            420                 425


<210>  67
<211>  2114
<212>  DNA
<213>  Homo sapiens

<400>  67
gtgctgacta caagggcaac ccagctctca gaggaactgg cccagctccg ggatgcctat     60

cagaagcaga aggagcagct gcggcaacaa ctagaagccc ctccaagcca gagggatggg    120

cactttctcc aggaaagccg gcgactctct gcccagtttg aaaatctcat ggcagagagc    180

cgccaggacc tggaggagga gtatgagcct cagttcctgc ggctcctaga gaggaaagaa    240

gctgggacca aagctctgca gagaacccag gctgagatcc aggaaatgaa ggaggctctg    300

agacccctgc aagcagaggc ccggcagctc cgcctgcaaa acaggaacct ggaggaccag    360

atcgcacttg tgaggcaaaa acgagatgaa gaggtgcagc agtacaggga acagctggag    420

gaaatggaag aacgccagag gcagttaaga aatggggtgc aactccagca acagaagaac    480

aaagagatgg aacagctaag gctcagtctt gctgaagagc tctctactta taaggctatg    540

ctactaccca agagcctgga acaggctgat gctcccactt ctcaggcagg tggaatggag    600

acacagtctc aaggggctgt ttagaaatat atggccaaat ctgtaacccg gaaacagcaa    660

aaaacttctt agcaaaggat cactaagtac cctttggatg tactcttcca accagacaag    720

agtgccagaa acttggcaag caattcatcc tgtggaagtt gcaaatactg gctgacctgc    780

ttaaaaagat tctagagttg gccggaggca gaacatgtca actctttgct ggattctatt    840

tcatctgctg ttgatactga tctcaatgca ccaaggaaag gaaagatgag cctcctgtct    900

tccagcaaca accctcacat atgcactgag taaaggatga atgtatggac acatctggga    960

gtattttaaa gaatgtatct tgccttgtgt tgacccaaac caaaaacatt tttgaggggc   1020

acatgtgggg tcaaaaagat agccaatttc cattacatgg gtttacaatt tccattcttt   1080

tgtgccacga gtgttagaat ttaaatgaat acttttacaa agtctacttt ttgttcaagg   1140

atatgctgac ccatatagtt tactcttaaa attgtgtcaa ggtatttctc actatactct   1200

aaaacaacta gacttgaaaa gaaaccattt gagatttgaa tctaatggtt aacgctattc   1260

agattttccc aaagatctta cctcatgaaa gtagttctgg gtcagaatga tctactcagt   1320

taaaaaacaa caacaacaaa aaactaagcg attgggaaaa aacaggaatt ttatctggtt   1380

attgcatctg gtgatagagg ccttcaaagc ctattatttc taacctaagt aaaggcccca   1440

gtgaaaaaca tactggggaa ataaaacctc tgagaaaagg ttcaagcacc ttttccaaat   1500

ttaaatcttg ccttaaattc tctctaccac actgcctttg acactcttgg aagtccatgt   1560

agttctctac agacagactt caaagaaacg ttaccttatc aaagactaat ctgtgccacc   1620

tctgattcag tgttttatgt ctttcacttt ccctgggaag gagtaaagtt cttttctaca   1680

gctctgggac tattacattt aattctgctc ttgatagtca aagaccatgg acaacaactg   1740

tcatctgaag gactcttcta gaagccagag actggtgttt gatggatgtt ttatactaaa   1800

taaaacccat cagcatgggg ttatgtagaa aagcaattta ttccatttta agcacttaca   1860

cagttagtca tggagagtaa caggcctgct ggtgaaacag gtcacccaaa atggagatgg   1920

catcaaacta gtggtcaagg actaactcct aaaaaaaaaa agcaactctt atcaaggatt   1980

aatttaattt ttaaaacaaa tacaagttat tgattcactc ttcccaactt gacagtctac   2040

ctgtggtata actgtcaggt aaaaacatac atctttacaa cttggtggtc ccaagttaaa   2100

aaaaaaaaaa aaaa                                                     2114


<210>  68
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Ala Glu Ser Arg Gln Asp Leu Glu Glu Glu Tyr Glu Pro Gln Phe 
1               5                   10                  15


Leu Arg Leu Leu Glu Arg Lys Glu Ala Gly Thr Lys Ala Leu Gln Arg 
            20                  25                  30


Thr Gln Ala Glu Ile Gln Glu Met Lys Glu Ala Leu Arg Pro Leu Gln 
        35                  40                  45


Ala Glu Ala Arg Gln Leu Arg Leu Gln Asn Arg Asn Leu Glu Asp Gln 
    50                  55                  60


Ile Ala Leu Val Arg Gln Lys Arg Asp Glu Glu Val Gln Gln Tyr Arg 
65                  70                  75                  80


Glu Gln Leu Glu Glu Met Glu Glu Arg Gln Arg Gln Leu Arg Asn Gly 
                85                  90                  95


Val Gln Leu Gln Gln Gln Lys Asn Lys Glu Met Glu Gln Leu Arg Leu 
            100                 105                 110


Ser Leu Ala Glu Glu Leu Ser Thr Tyr Lys Ala Met Leu Leu Pro Lys 
        115                 120                 125


Ser Leu Glu Gln Ala Asp Ala Pro Thr Ser Gln Ala Gly Gly Met Glu 
    130                 135                 140


Thr Gln Ser Gln Gly Ala Val 
145                 150


<210>  69
<211>  5422
<212>  DNA
<213>  Homo sapiens

<400>  69
gccgcagggg gcctgacccg ccgcccgctc cgcccccgcc tgccatggcg gcccgcgcgc     60

cccccgccgc acctgcggcc gaggagccgg ggaacccggg cggccccccg cgcaggaaga    120

agtcccgctc cggcgcgtcc ggcctccgcc gcgccttcag ctggctgcgg ggcaagcggc    180

gcaagaagaa ggcggcgggg gccgagggcg ccgaaccggc cgccccccgg gccaagaagg    240

cggaggacaa ggccaagagg gccaagggca aaggccgagg ctctgccaag gctgagaatg    300

acaaacatct aagtgtaggg cctggccagg ggccagggtc tgcagtggat gagcaccagg    360

acaacgtctt ctttcccagt gggcgacccc cccacctgga agagctgcac actcaggccc    420

aggaggggct ccgctcccta caacaccaag agaaacagaa actgaacaag ggtggctggg    480

accatggaga cacccagagt atccagtcct cccggacggg gccggatgaa gacaacatct    540

ccttctgcag tcagaccaca tcctacgtgg ctgagagctc cacagcagag gacgcgctct    600

ccatccgctc ggagatgatc cagcgcaaag gctccacctt ccgaccccat gactcatttc    660

ccaaatctgg aaagtcaggg cggcgtcggc gggagcggcg gagcactgtg ctgggactcc    720

cgcagcatgt gcagaaggag cttggcctga ggaatgagcg tgaggcacca ggcacgcccc    780

gggctcctgg tgcacgggat gccgtacgca tccccacagt ggacggccgc ccccgaggca    840

cctcagggat gggggcccgg gtgtccctgc aggcgctgga ggcggaggcg gaggctggcg    900

ctgagacaga ggccatgctg cagcgccaca ttgaccgtgt ctaccgggat gacacctttg    960

ttggccggtc cacgggtacc cgggccccac cattgacccg gcccatgtcc ctagcagtgc   1020

ctggattgac aggaggggca gggcctgcag agcccctgag cccggccatg tccatctccc   1080

cccaggccac ctacctgtcg aagttgattc cacatgctgt gctgccgcct acagtggacg   1140

tggtggccct aggccgctgc agcctgcgca cactaagccg ctgcagcctg cactcggcca   1200

gcccagcctc agtccgctcg ctggggcgct tctcctccgt ctccagccca cagccccgca   1260

gccgccaccc atcctcctcc agtgacacct ggagccactc tcaatcctcc gacaccattg   1320

tgtctgacgg ttccaccctc tcctctaagg gtggctctga gggccagccg gagagctcta   1380

cggctagcaa tagcgtggta ccccctcccc agggaggcag tgggaggggc tctcccagtg   1440

ggggcagcac tgctgaggcc tcagacacac tcagcattcg gagcagtggg cagttgtctg   1500

gccggagtgt gtccctgcgt aagctgaagc ggcctccacc ccctccccgc cggacccact   1560

ccctccatca gcggggctta gcagtgcctg atgggccatt agggttgccc cctaagcctg   1620

agcgtaagca gcagccccag ctgcctcggc cacccaccac tggtggctca gaaggggcgg   1680

gggcagcacc ctgtccaccc aacccagcca acagctgggt acctggcttg tctccgggtg   1740

gttcccggcg ccccccacgg tccccagaac ggacactttc gccctccagt ggatactcga   1800

gccaaagtgg tactcccacc ctccctccca agggcctggc aggtccccct gcttccccag   1860

gcaaggccca gccccctaaa ccagagcgtg tcacgtctct tcgctcccct ggggcctccg   1920

tctcctcttc cctcacgtct ttatgttcct cctcctctga cccagccccc tcagaccgct   1980

ctgggccaca gatattgacc cccctgggtg acaggtttgt catacctcct caccccaagg   2040

tgcctgcccc cttctcccca cctccctcca agcccaggag ccctaaccca gctgcccctg   2100

ctctagccgc ccctgctgtg gttcctgggc ctgtttctac cactgacgcc agtcctcagt   2160

cccctcccac tccccagaca accttgactc cactgcagga gtctcctgtc atctccaaag   2220

accagtcacc cccaccttcc ccacccccat cttatcatcc acccccacca cccactaaga   2280

agccagaggt ggttgtggag gcaccatctg cctcagagac tgctgaggag cccctccaag   2340

atcccaactg gccccctccc ccaccccctg cccctgagga gcaggacctg tccatggctg   2400

acttcccccc accagaggag gcttttttct ctgtggccag ccctgagcct gcaggccctt   2460

caggctcccc agagcttgtc agctccccgg ctgcttcgtc ctcctcagct actgctttgc   2520

agattcagcc cccgggtagc ccagaccctc ctccagctcc gccagcccca gctcctgcta   2580

gttccgcccc agggcatgtg gccaagctcc ctcagaagga accggtgggc tgtagcaagg   2640

gtggtgggcc tcccagggag gacgtaggtg cgcccctggt cacgccctcg ctcctgcaga   2700

tggtgcggct gcgctccgtg ggtgctccag gaggggctcc caccccagca ctggggccat   2760

cggcccccca gaaaccactg cgaagggccc tgtcagggcg ggccagccca gtgcctgccc   2820

cctcctcagg gctccatgct gcggtccgac tcaaggcctg cagcctggcc gccagtgaag   2880

gcctctcaag tgctcagccc aacggaccgc ctgaggcaga gccacggcct ccccagtccc   2940

ctgcctcaac ggccagtttc atcttctcca agggctctag gaagctgcag ctggagcggc   3000

ccgtgtcccc tgagacccag gctgacctcc agcggaatct ggtggcagaa ctccggagca   3060

tctcagagca gcggccaccc caggccccaa agaagtcacc taaggctccc ccacctgtgg   3120

cccgcaagcc gtctgtggga gtccccccac ccgcctcccc cagttaccct cgagctgagc   3180

cccttactgc tcctcccacc aatgggctcc ctcacaccca ggacaggact aagagggagc   3240

tggcggagaa tggaggtgtc ctgcagctgg tgggcccaga ggagaagatg ggcctcccgg   3300

gctcagactc acagaaagag ctggcctgac caccaggcac ctcactggca ctgctgaccc   3360

atcccagaaa cacaatctca gggacccgag cagctccaag gacgagagga tacagcagac   3420

acaacctaat agagagggcg cctgcagcct taacctccac ggccttcgat acttatgcaa   3480

gcctggtgtt gctcctgtcc tcagagtcat cctgcgctca tgccttttcc cgaatgggtt   3540

cacctctggc agttgccgct tcagtcttgg ccttagcctc atcttgaagt gggtagctgg   3600

cgggagaggg tggctgcgcc ccctgctggc cctgaggctg cagagttggg agcaggacac   3660

ctcacctgag tttcattttt tttcatgtcc aaaccatgca catactatag tccagaatca   3720

aagcactttt gaaaagtggc tgcatggcca tcctccaggg cccaggaagt tgcattccaa   3780

gggcctgttt acatggcagc agaatccatc cccggcagtc agcccatagc ttgggaccag   3840

tctgtgccct cctgcccagt ccagtttact cctcttggtt cctgaaggtg gccaagtcat   3900

tgtgttccca caggcttctc taggctgggg gcaggtgtgg ggctgtggaa ttccaaagca   3960

caaaaggtgc agaggggatt ggccttcctg tgcctcaact caccaaccac cctcctgcct   4020

tccagttctg ccaggtgctc catgctgggg acaagtagga gactgccagg gcccaaagaa   4080

atgggtgagc agtagagtca tctcggggca cttggcagtg tcaagcacct gccccttgcc   4140

tccttgacca cactggggtg ggtgggcccc cagcacttca gaggcaggag cctttgggct   4200

gagcaagcac tgaggaggtg gatggaaggg agcatctgga gggggggagc ttccttgagc   4260

agtgggccca ggcctggccc tccacacttc attctctgac ctttctctct cctcatttcg   4320

gtgcatgtcc tttctgcagc tgcctttcag cacaggtggt tccactgggg gcagctaacg   4380

ctgagtgaca aggatgggaa gccacaggtg cattttactc aagtcttctc tagtcaatga   4440

ggggcaccca gtgcttctag ggcaggctgg gtggtggtcc cctaggtatc agcctctctt   4500

actgtactct ccgggaatgt taacctttct attttcagcc tgtgccacct gtctaggcaa   4560

gctggcttcc ccattggccc ctgtgggtcc acagcagcgt ggctgccccc cagggccacc   4620

gcttctttct tgatcctctt tccttaacag tgacttgggc ttgagtctgg caaggaacct   4680

tgcttttagc ttcaccacca aggagagagg ttgacatgac ctccccgccc cctcaccaag   4740

gctgggaaca gaggggatgt ggtgagagcc aggttcctct ggccctctcc agggtgtttt   4800

ccactagtca ctactgtctt ctccttgtag ctaatcaatc aatattcttc ccttgcctgt   4860

gggcagtgga gagtgctgct gggtgtacgc tgcacctgcc cactgagttg gggaaagagg   4920

ataatcagtg agcactgttc tgctcagagc tcctgatcta ccccaccccc taggatccag   4980

gactgggtca aagctgcatg aaaccaggcc ctggcagcaa cctgggaatg gctggaggtg   5040

ggagagaacc tgacttctct ttccctctcc ctcctccaac attactggaa ctctatcctg   5100

ttaggatctt ctgagcttgt ttccctgctg ggtgggacag aggacaaagg agaagggagg   5160

gtctagaaga ggcagccctt ctttgtcctc tggggtaaat gagcttgacc tagagtaaat   5220

ggagagacca aaagcctctg atttttaatt tccataaaat gttagaagta tatatataca   5280

tatatatatt tctttaaatt tttgagtctt tgatatgtct aaaaatccat tccctctgcc   5340

ctgaagcctg agtgagacac atgaagaaaa ctgtgtttca tttaaagatg ttaattaaat   5400

gattgaaact tgaaaaaaaa aa                                            5422


<210>  70
<211>  1094
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Ala Ala Arg Ala Pro Pro Ala Ala Pro Ala Ala Glu Glu Pro Gly 
1               5                   10                  15


Asn Pro Gly Gly Pro Pro Arg Arg Lys Lys Ser Arg Ser Gly Ala Ser 
            20                  25                  30


Gly Leu Arg Arg Ala Phe Ser Trp Leu Arg Gly Lys Arg Arg Lys Lys 
        35                  40                  45


Lys Ala Ala Gly Ala Glu Gly Ala Glu Pro Ala Ala Pro Arg Ala Lys 
    50                  55                  60


Lys Ala Glu Asp Lys Ala Lys Arg Ala Lys Gly Lys Gly Arg Gly Ser 
65                  70                  75                  80


Ala Lys Ala Glu Asn Asp Lys His Leu Ser Val Gly Pro Gly Gln Gly 
                85                  90                  95


Pro Gly Ser Ala Val Asp Glu His Gln Asp Asn Val Phe Phe Pro Ser 
            100                 105                 110


Gly Arg Pro Pro His Leu Glu Glu Leu His Thr Gln Ala Gln Glu Gly 
        115                 120                 125


Leu Arg Ser Leu Gln His Gln Glu Lys Gln Lys Leu Asn Lys Gly Gly 
    130                 135                 140


Trp Asp His Gly Asp Thr Gln Ser Ile Gln Ser Ser Arg Thr Gly Pro 
145                 150                 155                 160


Asp Glu Asp Asn Ile Ser Phe Cys Ser Gln Thr Thr Ser Tyr Val Ala 
                165                 170                 175


Glu Ser Ser Thr Ala Glu Asp Ala Leu Ser Ile Arg Ser Glu Met Ile 
            180                 185                 190


Gln Arg Lys Gly Ser Thr Phe Arg Pro His Asp Ser Phe Pro Lys Ser 
        195                 200                 205


Gly Lys Ser Gly Arg Arg Arg Arg Glu Arg Arg Ser Thr Val Leu Gly 
    210                 215                 220


Leu Pro Gln His Val Gln Lys Glu Leu Gly Leu Arg Asn Glu Arg Glu 
225                 230                 235                 240


Ala Pro Gly Thr Pro Arg Ala Pro Gly Ala Arg Asp Ala Val Arg Ile 
                245                 250                 255


Pro Thr Val Asp Gly Arg Pro Arg Gly Thr Ser Gly Met Gly Ala Arg 
            260                 265                 270


Val Ser Leu Gln Ala Leu Glu Ala Glu Ala Glu Ala Gly Ala Glu Thr 
        275                 280                 285


Glu Ala Met Leu Gln Arg His Ile Asp Arg Val Tyr Arg Asp Asp Thr 
    290                 295                 300


Phe Val Gly Arg Ser Thr Gly Thr Arg Ala Pro Pro Leu Thr Arg Pro 
305                 310                 315                 320


Met Ser Leu Ala Val Pro Gly Leu Thr Gly Gly Ala Gly Pro Ala Glu 
                325                 330                 335


Pro Leu Ser Pro Ala Met Ser Ile Ser Pro Gln Ala Thr Tyr Leu Ser 
            340                 345                 350


Lys Leu Ile Pro His Ala Val Leu Pro Pro Thr Val Asp Val Val Ala 
        355                 360                 365


Leu Gly Arg Cys Ser Leu Arg Thr Leu Ser Arg Cys Ser Leu His Ser 
    370                 375                 380


Ala Ser Pro Ala Ser Val Arg Ser Leu Gly Arg Phe Ser Ser Val Ser 
385                 390                 395                 400


Ser Pro Gln Pro Arg Ser Arg His Pro Ser Ser Ser Ser Asp Thr Trp 
                405                 410                 415


Ser His Ser Gln Ser Ser Asp Thr Ile Val Ser Asp Gly Ser Thr Leu 
            420                 425                 430


Ser Ser Lys Gly Gly Ser Glu Gly Gln Pro Glu Ser Ser Thr Ala Ser 
        435                 440                 445


Asn Ser Val Val Pro Pro Pro Gln Gly Gly Ser Gly Arg Gly Ser Pro 
    450                 455                 460


Ser Gly Gly Ser Thr Ala Glu Ala Ser Asp Thr Leu Ser Ile Arg Ser 
465                 470                 475                 480


Ser Gly Gln Leu Ser Gly Arg Ser Val Ser Leu Arg Lys Leu Lys Arg 
                485                 490                 495


Pro Pro Pro Pro Pro Arg Arg Thr His Ser Leu His Gln Arg Gly Leu 
            500                 505                 510


Ala Val Pro Asp Gly Pro Leu Gly Leu Pro Pro Lys Pro Glu Arg Lys 
        515                 520                 525


Gln Gln Pro Gln Leu Pro Arg Pro Pro Thr Thr Gly Gly Ser Glu Gly 
    530                 535                 540


Ala Gly Ala Ala Pro Cys Pro Pro Asn Pro Ala Asn Ser Trp Val Pro 
545                 550                 555                 560


Gly Leu Ser Pro Gly Gly Ser Arg Arg Pro Pro Arg Ser Pro Glu Arg 
                565                 570                 575


Thr Leu Ser Pro Ser Ser Gly Tyr Ser Ser Gln Ser Gly Thr Pro Thr 
            580                 585                 590


Leu Pro Pro Lys Gly Leu Ala Gly Pro Pro Ala Ser Pro Gly Lys Ala 
        595                 600                 605


Gln Pro Pro Lys Pro Glu Arg Val Thr Ser Leu Arg Ser Pro Gly Ala 
    610                 615                 620


Ser Val Ser Ser Ser Leu Thr Ser Leu Cys Ser Ser Ser Ser Asp Pro 
625                 630                 635                 640


Ala Pro Ser Asp Arg Ser Gly Pro Gln Ile Leu Thr Pro Leu Gly Asp 
                645                 650                 655


Arg Phe Val Ile Pro Pro His Pro Lys Val Pro Ala Pro Phe Ser Pro 
            660                 665                 670


Pro Pro Ser Lys Pro Arg Ser Pro Asn Pro Ala Ala Pro Ala Leu Ala 
        675                 680                 685


Ala Pro Ala Val Val Pro Gly Pro Val Ser Thr Thr Asp Ala Ser Pro 
    690                 695                 700


Gln Ser Pro Pro Thr Pro Gln Thr Thr Leu Thr Pro Leu Gln Glu Ser 
705                 710                 715                 720


Pro Val Ile Ser Lys Asp Gln Ser Pro Pro Pro Ser Pro Pro Pro Ser 
                725                 730                 735


Tyr His Pro Pro Pro Pro Pro Thr Lys Lys Pro Glu Val Val Val Glu 
            740                 745                 750


Ala Pro Ser Ala Ser Glu Thr Ala Glu Glu Pro Leu Gln Asp Pro Asn 
        755                 760                 765


Trp Pro Pro Pro Pro Pro Pro Ala Pro Glu Glu Gln Asp Leu Ser Met 
    770                 775                 780


Ala Asp Phe Pro Pro Pro Glu Glu Ala Phe Phe Ser Val Ala Ser Pro 
785                 790                 795                 800


Glu Pro Ala Gly Pro Ser Gly Ser Pro Glu Leu Val Ser Ser Pro Ala 
                805                 810                 815


Ala Ser Ser Ser Ser Ala Thr Ala Leu Gln Ile Gln Pro Pro Gly Ser 
            820                 825                 830


Pro Asp Pro Pro Pro Ala Pro Pro Ala Pro Ala Pro Ala Ser Ser Ala 
        835                 840                 845


Pro Gly His Val Ala Lys Leu Pro Gln Lys Glu Pro Val Gly Cys Ser 
    850                 855                 860


Lys Gly Gly Gly Pro Pro Arg Glu Asp Val Gly Ala Pro Leu Val Thr 
865                 870                 875                 880


Pro Ser Leu Leu Gln Met Val Arg Leu Arg Ser Val Gly Ala Pro Gly 
                885                 890                 895


Gly Ala Pro Thr Pro Ala Leu Gly Pro Ser Ala Pro Gln Lys Pro Leu 
            900                 905                 910


Arg Arg Ala Leu Ser Gly Arg Ala Ser Pro Val Pro Ala Pro Ser Ser 
        915                 920                 925


Gly Leu His Ala Ala Val Arg Leu Lys Ala Cys Ser Leu Ala Ala Ser 
    930                 935                 940


Glu Gly Leu Ser Ser Ala Gln Pro Asn Gly Pro Pro Glu Ala Glu Pro 
945                 950                 955                 960


Arg Pro Pro Gln Ser Pro Ala Ser Thr Ala Ser Phe Ile Phe Ser Lys 
                965                 970                 975


Gly Ser Arg Lys Leu Gln Leu Glu Arg Pro Val Ser Pro Glu Thr Gln 
            980                 985                 990


Ala Asp Leu Gln Arg Asn Leu Val Ala Glu Leu Arg Ser Ile Ser Glu 
        995                 1000                1005


Gln Arg Pro Pro Gln Ala Pro Lys Lys Ser Pro Lys Ala Pro Pro Pro 
    1010                1015                1020


Val Ala Arg Lys Pro Ser Val Gly Val Pro Pro Pro Ala Ser Pro Ser 
1025                1030                1035                1040


Tyr Pro Arg Ala Glu Pro Leu Thr Ala Pro Pro Thr Asn Gly Leu Pro 
                1045                1050                1055


His Thr Gln Asp Arg Thr Lys Arg Glu Leu Ala Glu Asn Gly Gly Val 
            1060                1065                1070


Leu Gln Leu Val Gly Pro Glu Glu Lys Met Gly Leu Pro Gly Ser Asp 
        1075                1080                1085


Ser Gln Lys Glu Leu Ala 
    1090


<210>  71
<211>  3117
<212>  DNA
<213>  Homo sapiens

<400>  71
gcaacagcct cccgccgagc cggccgggac agaggcggcc cccaccccca ctgggcaggg     60

gactgcagac ggcgctcccc gactctcaag acgaccaggg agcttccctt ttcctcagcg    120

gggtgagggg catctgtcgc ccgccgactt ggaggtggag gggcagggac attccctcgc    180

catcacctca ggagctagaa cgcgcccttc tcgcagcagg gcgtgggcct cccaatccct    240

ccaaggggcg gacggcgtgc gcaaccccct ggagaagcaa caggcgcccc catccccctc    300

caagccgggt aacgccgacc ccctcgtccc tcccgctctt cacctccgga agccgggcca    360

aagcctgggc gaacgactgc gcctcactcc gccccctgcg ccattttatc gccccctccc    420

cgacctcccc taccccgagt cagccgggcc aacaccaggg ggagggcaaa ccagcagtga    480

ttggcaggaa accgtcccgc ctctaggagg gttgtgcccc gctcaggcgc ctcagccccg    540

ccctccgcac cgcccaccgt gcccactggc tccacctttt cccgtctcat cgacctgctc    600

gactctctgc tgctcctcac tttttccggc cgctgccgga ggggtccagg ccgagtaagc    660

ggagcgccga gcccagctga tgcaacctgg ctggactcgc gtgacagttc ccggcacgcg    720

gcggcgacgg tgacccagga aggggctctg gtgccgggct gagcggggga agcaggggta    780

gcggagccat gggggacgct cccagccctg aagagaaact gcaccttatc acccggaacc    840

tgcaggaggt tctgggggaa gagaagctga aggagatact gaaggagcgg gaacttaaaa    900

tttactgggg aacggcaacc acgggcaaac cacatgtggc ttactttgtg cccatgtcaa    960

agattgcaga cttcttaaag gcagggtgtg aggtaacaat tctgtttgcg gacctccacg   1020

catacctgga taacatgaaa gccccatggg aacttctaga actccgagtc agttactatg   1080

agaatgtgat caaagcaatg ctggagagca ttggtgtgcc cttggagaag ctcaagttca   1140

tcaaaggcac tgattaccag ctcagcaaag agtacacact agatgtgtac agactctcct   1200

ccgtggtcac acagcacgat tccaagaagg ctggagctga ggtggtaaag caggtggagc   1260

accctttgct gagtggcctc ttataccccg gactgcaggc tttggatgaa gagtatttaa   1320

aagtagatgc ccaatttgga ggcattgatc agagaaagat tttcaccttt gcagagaagt   1380

acctccctgc acttggctat tcaaaacggg tccatctgat gaatcctatg gttccaggat   1440

taacaggcag caaaatgagc tcttcagaag aggagtccaa gattgatctc cttgatcgga   1500

aggaggatgt gaagaaaaaa ctgaagaagg ccttctgtga gccaggaaat gtggagaaca   1560

atggggttct gtccttcatc aagcatgtcc tttttcccct taagtccgag tttgtgatcc   1620

tacgagatga gaaatggggt ggaaacaaaa cctacacagc ttacgtggac ctggaaaagg   1680

actttgctgc tgaggttgta catcctggag acctgaagaa ttctgttgaa gtcgcactga   1740

acaagttgct ggatccaatc cgggaaaagt ttaatacccc tgccctgaaa aaactggcca   1800

gcgctgccta cccagatccc tcaaagcaga agccaatggc caaaggccct gccaagaatt   1860

cagaaccaga ggaggtcatc ccatcccggc tggatatccg tgtggggaaa atcatcactg   1920

tggagaagca cccagatgca gacagcctgt atgtagagaa gattgacgtg ggggaagctg   1980

aaccacggac tgtggtgagc ggcctggtac agttcgtgcc caaggaggaa ctgcaggaca   2040

ggctggtagt ggtgctgtgc aacctgaaac cccagaagat gagaggagtc gagtcccaag   2100

gcatgcttct gtgtgcttct atagaaggga taaaccgcca ggttgaacct ctggaccctc   2160

cggcaggctc tgctcctggt gagcacgtgt ttgtgaaggg ctatgaaaag ggccaaccag   2220

atgaggagct caagcccaag aagaaagtct tcgagaagtt gcaggctgac ttcaaaattt   2280

ctgaggagtg catcgcacag tggaagcaaa ccaacttcat gaccaagctg ggctccattt   2340

cctgtaaatc gctgaaaggg gggaacatta gctagccagc ccagcatctt ccccccttct   2400

tccaccactg agtcatctgc tgtctcttca gtctgctcca tccatcaccc atttacccat   2460

ctctcaggac acggaagcag cgggtttgga ctctttattc ggtgcagaac tcggcaaggg   2520

gcagcttacc ctccccagaa cccaggatca tcctgtctgg ctgcagtgag agaccaaccc   2580

ctaacaaggg ctgggccaca gcagggagtc cagccctacc ttcttccctt ggcagctgga   2640

gaaatctggt ttcaatataa ctcatttaaa aatttatgcc acagtcctta taattggaaa   2700

aatactggtg cccaggtttt cttggagtta tccaagcagc tgcgccccta gctgggatct   2760

ggtacctgga ctaggctaat tacagcttct ccccaacagg aaactgtggg atttgaaaag   2820

gaaagggaag ggaaaacaga gaacctagtg gtctaccaag tggttggcaa ctttcccaat   2880

gtctgcttac tctgaggctt ggcactgggg gccagggcct gccccagggc tcctggaatt   2940

tcccttgatc cagctaggct gggacactcc ctaaatcagc tgcgtgttgt tagcatcagg   3000

cagaatgaat ggcagagagt gattctgtct tcatagaggg tggggtactt ctccataagg   3060

catctcagtc aaatccccat cactgtcata aattcaaata aaatgtctga acaaggg      3117


<210>  72
<211>  528
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg 
1               5                   10                  15


Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys 
            20                  25                  30


Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro 
        35                  40                  45


His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys 
    50                  55                  60


Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu 
65                  70                  75                  80


Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr 
                85                  90                  95


Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu 
            100                 105                 110


Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu 
        115                 120                 125


Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp 
    130                 135                 140


Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu 
145                 150                 155                 160


Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr 
                165                 170                 175


Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe 
            180                 185                 190


Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val 
        195                 200                 205


His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser 
    210                 215                 220


Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp 
225                 230                 235                 240


Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu 
                245                 250                 255


Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys 
            260                 265                 270


Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr 
        275                 280                 285


Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val 
    290                 295                 300


His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu 
305                 310                 315                 320


Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu 
                325                 330                 335


Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys 
            340                 345                 350


Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu 
        355                 360                 365


Asp Ile Arg Val Gly Lys Ile Ile Thr Val Glu Lys His Pro Asp Ala 
    370                 375                 380


Asp Ser Leu Tyr Val Glu Lys Ile Asp Val Gly Glu Ala Glu Pro Arg 
385                 390                 395                 400


Thr Val Val Ser Gly Leu Val Gln Phe Val Pro Lys Glu Glu Leu Gln 
                405                 410                 415


Asp Arg Leu Val Val Val Leu Cys Asn Leu Lys Pro Gln Lys Met Arg 
            420                 425                 430


Gly Val Glu Ser Gln Gly Met Leu Leu Cys Ala Ser Ile Glu Gly Ile 
        435                 440                 445


Asn Arg Gln Val Glu Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro Gly 
    450                 455                 460


Glu His Val Phe Val Lys Gly Tyr Glu Lys Gly Gln Pro Asp Glu Glu 
465                 470                 475                 480


Leu Lys Pro Lys Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Lys 
                485                 490                 495


Ile Ser Glu Glu Cys Ile Ala Gln Trp Lys Gln Thr Asn Phe Met Thr 
            500                 505                 510


Lys Leu Gly Ser Ile Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile Ser 
        515                 520                 525


<210>  73
<211>  1483
<212>  DNA
<213>  Homo sapiens

<400>  73
ctggtgttgg cccggctgac tcggggtagg ggaggtcggg gagggggcga taaaatggcg     60

cagggggcgg agtgaggcgc agtcgttcgc ccaggctttg gcccggcttc cggaggaagg    120

tgggagtcaa tcattttgac aagtctcctg aaaggaacag ctagcaggaa ctgaaacctt    180

tttccatttg gtctcgtggc aaaggcagag attgctccag cagctccaca caaaatgatg    240

tgctcacggg tgccctctga acagtcttct ggtacctctc tcttgcctaa agacggtgcc    300

ccattttctt gggattcctt ggatgaggat ggattggatg actccttgct ggagctgtca    360

gagggagaag aagatgatgg tgatgtaaat tacacagagg aagagattga tgcactgttg    420

aaggaagatg acccatcata tgagcagtct tctggggaag atgatggtgg gcatgttgag    480

aagggagaaa gagggagtca aattctactt gatactcccc gagagaaaaa ttcatcgtac    540

agcctgggac cagtagctga gactcctgac ctcttcaaac tacctcagct aagtacatca    600

agtggtcatg gaccagctca tactaaacca ttaaacagac gctctgtact agaaaagaat    660

cttataaaag taactgttgc accatttaat ccaacagttt gtgatgctct gcttgataag    720

gacgagactg attcgtccaa agatactgaa aaactctctt cccttggaga agagatgaga    780

gaagatggtc ttagcccaaa tgaaagcaaa ctttgtactg aatctgaagg gatcagcccc    840

aataactctg cctggaatgg gccccagctc tcttcttcaa acaataactt tcaacagact    900

gtctctgata aaaatatgcc tgacagtgag aaccctacgt ctgtattctc tcggatctca    960

gaccattcag agactcctaa tatggagtta tcctgcagaa atggtggttc acacaagtca   1020

agttgtgaaa tgagatctct ggttgtttcc acctcatcaa acaaagatgt tcttaacaag   1080

gattctggga agatgaaagg ccatgagaga agactaggca aagtcattcc tgttctacaa   1140

actaagacca ggactaatgt tccgacgttt tcacagtcaa atctagaaca gcagaagcag   1200

ctttatctca ggagtgtcat tgctcatata gaagacccag aggacactaa ccaaggatga   1260

atccctagaa gtggaattgc tgggcgcagt ggctcatgcc tgtaatccca gcactttggg   1320

aggctgaggc agatggatca tctgaggtca ggagttcaag accagcctga ctaacatgat   1380

gaaacctgtc tctactaaaa atataaaaat tagctgggcg tggtggtggg cgcctgtaat   1440

cccagctact cgggaggctg aggcaggaga atctcttgaa ccc                     1483


<210>  74
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Met Cys Ser Arg Val Pro Ser Glu Gln Ser Ser Gly Thr Ser Leu 
1               5                   10                  15


Leu Pro Lys Asp Gly Ala Pro Phe Ser Trp Asp Ser Leu Asp Glu Asp 
            20                  25                  30


Gly Leu Asp Asp Ser Leu Leu Glu Leu Ser Glu Gly Glu Glu Asp Asp 
        35                  40                  45


Gly Asp Val Asn Tyr Thr Glu Glu Glu Ile Asp Ala Leu Leu Lys Glu 
    50                  55                  60


Asp Asp Pro Ser Tyr Glu Gln Ser Ser Gly Glu Asp Asp Gly Gly His 
65                  70                  75                  80


Val Glu Lys Gly Glu Arg Gly Ser Gln Ile Leu Leu Asp Thr Pro Arg 
                85                  90                  95


Glu Lys Asn Ser Ser Tyr Ser Leu Gly Pro Val Ala Glu Thr Pro Asp 
            100                 105                 110


Leu Phe Lys Leu Pro Gln Leu Ser Thr Ser Ser Gly His Gly Pro Ala 
        115                 120                 125


His Thr Lys Pro Leu Asn Arg Arg Ser Val Leu Glu Lys Asn Leu Ile 
    130                 135                 140


Lys Val Thr Val Ala Pro Phe Asn Pro Thr Val Cys Asp Ala Leu Leu 
145                 150                 155                 160


Asp Lys Asp Glu Thr Asp Ser Ser Lys Asp Thr Glu Lys Leu Ser Ser 
                165                 170                 175


Leu Gly Glu Glu Met Arg Glu Asp Gly Leu Ser Pro Asn Glu Ser Lys 
            180                 185                 190


Leu Cys Thr Glu Ser Glu Gly Ile Ser Pro Asn Asn Ser Ala Trp Asn 
        195                 200                 205


Gly Pro Gln Leu Ser Ser Ser Asn Asn Asn Phe Gln Gln Thr Val Ser 
    210                 215                 220


Asp Lys Asn Met Pro Asp Ser Glu Asn Pro Thr Ser Val Phe Ser Arg 
225                 230                 235                 240


Ile Ser Asp His Ser Glu Thr Pro Asn Met Glu Leu Ser Cys Arg Asn 
                245                 250                 255


Gly Gly Ser His Lys Ser Ser Cys Glu Met Arg Ser Leu Val Val Ser 
            260                 265                 270


Thr Ser Ser Asn Lys Asp Val Leu Asn Lys Asp Ser Gly Lys Met Lys 
        275                 280                 285


Gly His Glu Arg Arg Leu Gly Lys Val Ile Pro Val Leu Gln Thr Lys 
    290                 295                 300


Thr Arg Thr Asn Val Pro Thr Phe Ser Gln Ser Asn Leu Glu Gln Gln 
305                 310                 315                 320


Lys Gln Leu Tyr Leu Arg Ser Val Ile Ala His Ile Glu Asp Pro Glu 
                325                 330                 335


Asp Thr Asn Gln Gly 
            340


<210>  75
<211>  4317
<212>  DNA
<213>  Homo sapiens

<400>  75
ctggtgttgg cccggctgac tcggggtagg ggaggtcggg gagggggcga taaaatggcg     60

cagggggcgg agtgaggcgc agtcgttcgc ccaggctttg gcccggcttc cggaggaagg    120

tgggagtcaa tcattttgac aagtctcctg aaaggaacag ctagcaggaa ctgaaacctt    180

tttccatttg gtctcgtggc aaaggcagag attgctccag cagctccaca caaaatgatg    240

tgctcacggg tgccctctga acagtcttct ggtacctctc tcttgcctaa agacggtgcc    300

ccattttctt gggattcctt ggatgaggat ggattggatg actccttgct ggagctgtca    360

gagggagaag aagatgatgg tgatgtaaat tacacagagg aagagattga tgcactgttg    420

aaggaagatg acccatcata tgagcagtct tctggggaag atgatggtgg gcatgttgag    480

aagggagaaa gagggagtca aattctactt gatactcccc gagagaaaaa ttcatcgtac    540

agcctgggac cagtagctga gactcctgac ctcttcaaac tacctcagct aagtacatca    600

agtggtcatg gaccagctca tactaaacca ttaaacagac gctctgtact agaaaagaat    660

cttataaaag taactgttgc accatttaat ccaacagttt gtgatgctct gcttgataag    720

gacgagactg attcgtccaa agatactgaa aaactctctt cccttggaga agagatgaga    780

gaagatggtc ttagcccaaa tgaaagcaaa ctttgtactg aatctgaagg gatcagcccc    840

aataactctg cctggaatgg gccccagctc tcttcttcaa acaataactt tcaacagact    900

gtctctgata aaaatatgcc tgacagtgag aaccctacgt ctgtattctc tcggatctca    960

gaccattcag agactcctaa tatggagtta tcctgcagaa atggtggttc acacaagtca   1020

agttgtgaaa tgagatctct ggttgtttcc acctcatcaa acaaacagga tgttcttaac   1080

aaggattctg ggaagatgaa aggccatgag agaagactag gcaaagtcat tcctgttcta   1140

caaactaaga ccaggactaa tgttccgacg ttttcacagt caaatctaga acagcagaag   1200

cagctttatc tcaggagtgt cattgctcat atagaagacc cagaggacac taaccaaggt   1260

atctcggggg agctttgtgc cttgatggat caagttcatc atatgcagca ctcaaaatgg   1320

cagcatcctt cggacctcac cacgcgaaac tacgcccgcc gacagaaaca tctgcaaaga   1380

tacagtctga ctcagtgggt tgacaggaac atgcgaagcc accatcggtt ccagcgtctc   1440

ccagacttct cgtacagtta atttgtgtca tcccatcagc aatgaaggtc cctatccagg   1500

gtcctgcttg gagcagcatt tcatgttctt ttgctgtttt gtgctttgcc gattttggat   1560

tttatttttc acaaaatttt tatttaaaaa actcgtcacc ttttggaaat gcccattgcc   1620

gacttgaatt tttttgtatg aagtccctcc tgattttgtg tgtgtgtgtc tgtgtttaag   1680

caagcgttcg gttggtatag tttttttttg tttttttaat ttaaattgaa ggtagctgcc   1740

tcctgaaagc cagcattaag ccagaacacc caggttcaag caaaagaccc acctctctgc   1800

agaggcaaag tctactttct ggtacctcaa agaaatcatt gttcaatctt ccataaggaa   1860

gagattcttt accaggctgt gagccagtgt tagataactt gtgaatggat ataagttact   1920

tttaacaacc cctcttactt ttttatttga atcctctgaa tacctgtcag tattttaaag   1980

ttggcaatcc aggacattat aagtaggatg gagcaggaga agaatcctat tgaaaggaca   2040

aattaaaata gtaaatcctc tcctctccct tctgtaggta ctagctgcct tgattttttt   2100

ttgtgggtgg gggggatttt ttcattcctt attgaactta ttttgcacaa tagtgtttac   2160

aaatcttata catcttactt tgacagaaga cttataatac cttgtggtct tgagactggt   2220

tgtctccttt gcctttcttc aaggattttc ctttttcttt ttacccccca gtgaccactc   2280

tgctctttag gattctagtg gcagtattct tgtaacctgt tagacgtgga tatacctctt   2340

caggatggcc tccttgctgt ctttattgaa gagctgccca cccagagtct tgactctagg   2400

gcaggctagt gctattgtgg tgtcagttga tatttagttt catttgctga accccaaatt   2460

tgagtgttag ttagggagcc tccattctgt gggagagtgt ggaaaggcac tcttttttct   2520

ccatattagt taacaagagg tgtctttagg ccctggatgt taccatctca tttggtcaag   2580

cccctgatac ctagtttcac atggatgcta acgtggatgt aatatagttg tgacagccta   2640

tgcacaaaag cattacctga tcttaaggtt tggtattcta accaaagttg acagactgtg   2700

cgtctgtctt aatggatgtc ttaggagttg gttattctct cttttttttt tgagacggag   2760

tttcgctgtt gttgcccagg ctggagtgca atggcgtatc tccactcacc acaacctccg   2820

cctcctgggt tcaagggatt ctcctgtctt agcctcctga gtagctgtga ttacaggcat   2880

gcgccaccat gcctggctaa tttcatattt tttagtagag acaggatttc tccatgttgg   2940

tcaggctggt cttgaactcc tgacctcagg tgatctgccc acctcggcct cctaaagtgc   3000

tgggattaca ggcatgagcc actgcacctg gccggttatt ctctctttac agatagctat   3060

agacatcatt ttaggaagtg ttgcagtctg gcatttgtgc tattgttcat tctctgtgaa   3120

ggctgttcat agttgctata gcctgtgttt agttttgtga tttcatcaat cccatctttc   3180

tgtgtgagta atgcattcta aacatcctac cccactttag aaacggacgt ggggaacgct   3240

tggtcattta agccaacaat aaatttaggt gaatgtccct aagtgtttac tgtttttatc   3300

cagtcaagga tttgcttttc cttgaacatt tgttttaaat tctggggcca aaatgcaaag   3360

gagaagttct attcaaaggc agtagttgaa atctattatt ttagttagcc tacttggcat   3420

ttactacatc ggtcacttct ccaggctgcc ctaaattagg ttgatggagt gagacatgcc   3480

aaacatccac ctttgggacc atagcatagt taaaattaaa tgtagttgga atagctagca   3540

ttgcagctac agtagggaac tgtagtctag ttccctacag aaaacccaag gagtgaaggg   3600

acaggatttt gcctaggcaa aaatctaaga ctcgtgccct cctggtacat ggggttttaa   3660

gactgaatgt gtaataggag cactgccttt gccaaatcaa atgagtgaca ggttaactag   3720

aaaatgtgac aatcacattt cctcttagct caaataattc tgtttttcca aagctttagc   3780

agcttaatta aatctgttgg actgggggag gagagagctg ttctctagtg gttaacatgg   3840

tattctttaa gaagaaaaaa caaagccaaa gaaaactcat tatctggcat gttcgcctta   3900

aagatggtac tgggtagaat ctggagtttt catctctttt caaagctgca tatctcttat   3960

atttggtatt ggcctctaag tctaatattg cagttggaat tcttgctgta ttatttttta   4020

agcaagtgtt aggtgcattt aactgctttc ttcatccatg acgacattcc caccatgggg   4080

gtcttgacaa agcagagtaa aaatatgctg tttacattgt ttacttacaa gtaaggagcc   4140

tgaaataacc tgtagtttcg aatgcaggcc ctgatttact ggcgttgtca gtttcaatta   4200

tgaaactgaa gtttggtgcc tcctctttat catgtttttt cccttgtagc agttgtgttt   4260

aatgtcatta aaaagaaata aaagttcttt gtcagtgaaa aaaaaaaaaa aaaaaaa      4317


<210>  76
<211>  408
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Met Cys Ser Arg Val Pro Ser Glu Gln Ser Ser Gly Thr Ser Leu 
1               5                   10                  15


Leu Pro Lys Asp Gly Ala Pro Phe Ser Trp Asp Ser Leu Asp Glu Asp 
            20                  25                  30


Gly Leu Asp Asp Ser Leu Leu Glu Leu Ser Glu Gly Glu Glu Asp Asp 
        35                  40                  45


Gly Asp Val Asn Tyr Thr Glu Glu Glu Ile Asp Ala Leu Leu Lys Glu 
    50                  55                  60


Asp Asp Pro Ser Tyr Glu Gln Ser Ser Gly Glu Asp Asp Gly Gly His 
65                  70                  75                  80


Val Glu Lys Gly Glu Arg Gly Ser Gln Ile Leu Leu Asp Thr Pro Arg 
                85                  90                  95


Glu Lys Asn Ser Ser Tyr Ser Leu Gly Pro Val Ala Glu Thr Pro Asp 
            100                 105                 110


Leu Phe Lys Leu Pro Gln Leu Ser Thr Ser Ser Gly His Gly Pro Ala 
        115                 120                 125


His Thr Lys Pro Leu Asn Arg Arg Ser Val Leu Glu Lys Asn Leu Ile 
    130                 135                 140


Lys Val Thr Val Ala Pro Phe Asn Pro Thr Val Cys Asp Ala Leu Leu 
145                 150                 155                 160


Asp Lys Asp Glu Thr Asp Ser Ser Lys Asp Thr Glu Lys Leu Ser Ser 
                165                 170                 175


Leu Gly Glu Glu Met Arg Glu Asp Gly Leu Ser Pro Asn Glu Ser Lys 
            180                 185                 190


Leu Cys Thr Glu Ser Glu Gly Ile Ser Pro Asn Asn Ser Ala Trp Asn 
        195                 200                 205


Gly Pro Gln Leu Ser Ser Ser Asn Asn Asn Phe Gln Gln Thr Val Ser 
    210                 215                 220


Asp Lys Asn Met Pro Asp Ser Glu Asn Pro Thr Ser Val Phe Ser Arg 
225                 230                 235                 240


Ile Ser Asp His Ser Glu Thr Pro Asn Met Glu Leu Ser Cys Arg Asn 
                245                 250                 255


Gly Gly Ser His Lys Ser Ser Cys Glu Met Arg Ser Leu Val Val Ser 
            260                 265                 270


Thr Ser Ser Asn Lys Gln Asp Val Leu Asn Lys Asp Ser Gly Lys Met 
        275                 280                 285


Lys Gly His Glu Arg Arg Leu Gly Lys Val Ile Pro Val Leu Gln Thr 
    290                 295                 300


Lys Thr Arg Thr Asn Val Pro Thr Phe Ser Gln Ser Asn Leu Glu Gln 
305                 310                 315                 320


Gln Lys Gln Leu Tyr Leu Arg Ser Val Ile Ala His Ile Glu Asp Pro 
                325                 330                 335


Glu Asp Thr Asn Gln Gly Ile Ser Gly Glu Leu Cys Ala Leu Met Asp 
            340                 345                 350


Gln Val His His Met Gln His Ser Lys Trp Gln His Pro Ser Asp Leu 
        355                 360                 365


Thr Thr Arg Asn Tyr Ala Arg Arg Gln Lys His Leu Gln Arg Tyr Ser 
    370                 375                 380


Leu Thr Gln Trp Val Asp Arg Asn Met Arg Ser His His Arg Phe Gln 
385                 390                 395                 400


Arg Leu Pro Asp Phe Ser Tyr Ser 
                405


<210>  77
<211>  13108
<212>  DNA
<213>  Homo sapiens

<400>  77
tcctgggatg gggtaggagg ctattgtgaa tgaggctcat aagcatcgcc cccggcccta     60

gatggcaagt tcaaagccac cacccaagat cagctggcca gaactgcacg ttccaactgc    120

acggtcccaa tgggacagtt gagagcccag ggttcccata tggctacccc aattacgcca    180

actgcacgtg gaccatcacc gcggaagagc agcacagaat ccagcttgtg ttccagtcct    240

ttgccctgga agaggacttt gatgtcctgt cggtgtttga tggtccaccc cagccagaga    300

atctgcgtac gaggctcaca ggctttcagc tgccagccac cattgttagt gcagccacca    360

ccctctctct gcgcctcatc agcgactatg cagtcagtgc ccaaggcttc cacgccacct    420

atgaagttct ccccagccac acatgtggga acccagggag gctgcccaat ggcatccagc    480

agggttcaac cttcaacctc ggtgacaagg tccgctacag ctgcaacctt ggcttcttcc    540

tggagggcca cgccgtgctc acctgccacg ctggctctga gaacagcgcc acgtgggact    600

tccccctgcc ttcctgcaga gctgatgatg cctgtggtgg gaccctgcgg ggccagagtg    660

gcatcatctc cagcccccac ttcccctcgg agtaccataa caatgccgac tgcacatgga    720

ccatcctggc tgagctgggg gacaccatcg ccctggtgtt tattgacttc cagctggagg    780

atggttacga ctttctggaa gtcactggga cagaaggctc ctccctctgg ttcaccggag    840

ccagcctccc agcccccgtt atcagcagca agaactggct gcgactgcac ttcacatcgg    900

atggcaacca ccggcagcgc ggattcagtg cccaatacca agtcaagaag caaattgagt    960

tgaagtctcg aggtgtgaag ctgatgccca gcaaagacaa cagccagaag acgtctgtgt   1020

taactcaggt tggtgtgtcc caaggacata atatgtgtcc agaccctggc atacccgaaa   1080

ggggcaaaag actaggctcg gatttcaggt taggatccag cgtccagttc acctgcaacg   1140

agggctatga cctgcaaggg tccaagcgga tcacctgtat gaaagtgagc gacatgtttg   1200

cggcctggag cgaccacagg ccagtctgcc gagcccgcat gtgtgatgcc caccttcgag   1260

gcccctcggg catcatcacc tcccccaatt tccccattca gtatgacaac aatgcacact   1320

gtgtgtggat catcacagca ctcaacccct ccaaggtgat caagctcgcc tttgaggagt   1380

ttgatttgga gaggggctat gacaccctga cggtcggtga tggtggtcag gatggggacc   1440

agaagacagt tctctacatc ctgacaggta catcggtccc ggatctcatt gtcagcacca   1500

atcatcaaat gtggctcctc ttccagactg atggcagtgg cagttccctg ggattcaagg   1560

cttcttatga agagatcgag cagggcagtt gcggtgaccc tggcatacct gcatatggcc   1620

ggagggaagg ctcccggttt caccacggtg acacactcaa gtttgagtgc cagcccgcct   1680

ttgagctggt gggacagaag gcaatcacat gccaaaagaa taaccaatgg tcggctaaga   1740

agccaggctg cgtgttctcc tgcttcttca acttcaccag cccgtctggg gttgtcctgt   1800

ctcccaacta cccagaggac tatggcaacc acctccactg tgtctggctc atcctggcca   1860

ggcctgagag ccgcatccac ctggccttca acgacattga cgtggagcct cagtttgatt   1920

tcctggtcat caaggatggg gccaccgccg aggcgcccgt cctgggcacc ttctcaggaa   1980

accagcttcc ctcctccatc acaagcagtg gccacgtggc ccgtctcgag ttccagactg   2040

accactccac agggaagagg ggcttcaaca tcacttttac caccttccga cacaacgagt   2100

gcccggatcc tggcgttcca gtaaatggca aacggtttgg ggacagcctc cagctgggca   2160

gctccatctc cttcctctgt gatgaaggct tccttgggac tcagggctca gagaccatca   2220

cctgcgtcct gaaggagggc agcgtggtct ggaacagcgc tgtgctgcgg tgtgaagctc   2280

cctgtggtgg tcacctgact tcgcccagcg gcaccatcct ctctccgggc tggcctggct   2340

tctacaagga tgccttgagc tgtgcctggg tgattgaggc ccagccaggc taccccatca   2400

aaatcacctt cgacagattc aaaaccgagg tcaactatga caccctggaa gtacgcgatg   2460

ggcggactta ctcagcgccc ttgatcgggg tttaccacgg gacccaggtt ccccagttcc   2520

tcatcagcac cagcaactac ctctacctcc tcttctctac cgacaagagt cactcggaca   2580

tcggcttcca gctccgctat gagactataa cactgcagtc agaccactgt ctggatccag   2640

gaatcccagt aaatggacag cgtcatggga atgacttcta cgtgggcgcg ctggtgacct   2700

tcagctgtga ctcgggctac acattaagtg acggggagcc tctggagtgt gagcccaact   2760

tccagtggag ccgggccctg cccagttgtg aagctctctg tggtggcttc attcaaggct   2820

ccagtgggac catcttgtcg ccagggttcc ctgacttcta ccccaacaac ttgaactgca   2880

cctggattat cgaaacatct catggcaagg gtgtgttctt cactttccac accttccacc   2940

tggaaagtgg ccatgactac ctcctcatca ctgagaacgg cagcttcacc cagcccctga   3000

ggcagctaac tggatctcgg ctgccagctc ccatcagcgc tgggctctat ggcaacttca   3060

ctgcccaggt ccgcttcatc tctgatttct ccatgtcata tgaaggattc aacatcacct   3120

tctcagagta cgacttggag ccctgtgagg agcccgaggt cccagcctac agcatccgga   3180

agggcttgca gtttggcgtg ggcgacacct tgaccttctc ctgcttcccc gggtaccgtc   3240

tggagggcac cgcccgcatc acgtgcctgg ggggcagacg gcgcctgtgg agctcgcctc   3300

tgccaaggtg tgttgctgag tgtgggaatt cagtcacagg cactcagggt actttgctgt   3360

cccccaactt tcctgtgaac tacaataaca atcatgaatg catctactcc atccagaccc   3420

agccagggaa gggaattcag ctgaaagcca gggcattcga actctccgaa ggagatgtcc   3480

tcaaggttta tgatggcaac aacaactccg cccgtttgct gggagttttt agccattctg   3540

agatgatggg ggtgactttg aacagcacat ccagcagtct gtggcttgat ttcatcactg   3600

atgctgaaaa caccagcaag ggctttgaac tgcacttttc cagctttgaa ctcatcaaat   3660

gtgaggaccc aggaaccccc aagtttggct acaaggttca tgatgaaggt cattttgcag   3720

ggagctccgt gtccttcagc tgtgaccctg gatacagcct gcggggtagt gaggagctgc   3780

tgtgtctgag tggagagcgc cggacctggg accggcctct gcccacctgt gtcgccgagt   3840

gtggagggac agtgagagga gaggtgtcgg ggcaggtgct gtcacccggg tatccagctc   3900

cctatgaaca caatctcaac tgcatctgga ccatcgaagc agaggccggc tgcaccattg   3960

ggctacactt cctggtgttt gacacagagg aggttcacga cgtgctgcgc atctgggatg   4020

ggcctgtgga gagcggggtt ctgctgaagg agctgagtgg cccggccctg cccaaggacc   4080

tgcatagcac cttcaactcg gtcgtcctgc agttcagcac tgacttcttc accagcaagc   4140

agggctttgc cattcaattt tcagtgtcca cagcaacgtc ctgcaatgac cctgggatcc   4200

cgcagaatgg gagtcggagt ggtgacagtt gggaagccgg cgactccaca gtgttccagt   4260

gtgaccctgg ctacgcgctg cagggaagtg cagagatcag ctgtgtgaag atcgagaaca   4320

ggttcttctg gcagcccagc ccgccaacat gcatcgctcc ctgcggggga gacctgacag   4380

gaccatctgg agtcatcctc tcaccaaatt acccagaacc ctacccgcca ggcaaggagt   4440

gtgactggaa agtgaccgtc tcaccagact acgtcatcgc cctggtattt aacatcttta   4500

acctggagcc tggctatgac ttcctccata tctacgacgg acgggactct ctcagccctc   4560

tcataggaag cttctatggc tcccagctcc caggccgcat tgaaagcagc agcaacagcc   4620

tcttcctcgc cttccgcagc gatgcatctg tgagcaatgc tggcttcgtc attgactata   4680

cagaaaaccc gcgggagtca tgttttgatc ctggttccat caagaacggc acacgggtgg   4740

ggtccgacct gaagctgggc tcctccgtca cctactactg ccacgggggc tacgaagttg   4800

agggcacctc gaccctgagc tgcatcctgg ggcctgatgg gaagcccgtg tggaacaatc   4860

cccggccagt ctgcacagcc ccctgtgggg gacagtatgt gggttcggac ggagtggtct   4920

tgtcccccaa ctacccccag aactacacca gtggacagat ctgcttgtat tttgttactg   4980

tgcccaagga ctatgtggtg tttggccagt tcgccttctt tcacacggcc ctcaacgacg   5040

tggtggaggt tcacgacggc cacagccagc actcgcggct cctcagctcc ctctcgggct   5100

cccatacagg agaatcactg cccttggcca cctccaatca agttctcatt aagttcagcg   5160

ccaaaggcct cgcaccagcc agaggcttcc actttgtcta ccaagcggtt cctcgaacca   5220

gcgccacgca gtgcagctct gtgccggaac cccgctatgg caagaggctg ggcagtgact   5280

tctcggtggg ggccatcgtc cgcttcgaat gcaactccgg ctatgccctg caggggtcgc   5340

cagagatcga gtgcctccct gtgcctgggg ccttggccca atggaatgtc tcagcgccca   5400

cgtgtgtggt gccgtgtgga ggcaacctca cagagcgcag gggcaccatc ctgtcccctg   5460

gcttcccaga gccgtacctc aacagcctca actgtgtgtg gaagatcgtg gtccccgaag   5520

gcgctggcat ccagatccaa gttgtcagtt ttgtgacaga gcagaactgg gactcgctgg   5580

aagtatttga tggtgcagat aacactgtaa ccatgctggg gagtttctca ggaacaaccg   5640

tgcctgccct tctgaacagc acctccaacc agctctacct tcatttctac tcagatatca   5700

gcgtatctgc agctggcttc cacttggagt acaaaacggt gggcctgagc agttgtccgg   5760

aacctgctgt gcccagtaac ggggtgaaga ctggcgagcg ctacttggtg aatgatgtgg   5820

tgtctttcca gtgtgagccg ggatatgccc tccagggcca cgcccacatc tcctgcatgc   5880

ccggaacagt gcggcgatgg aactaccctc ctccactctg tattgcacag tgtgggggaa   5940

cagtggagga gatggagggg gtgatcctga gccccggctt cccaggcaac taccccagta   6000

acatggactg ctcctggaaa atagcactgc ccgtgggctt tggagctcac atccagttcc   6060

tgaacttctc caccgagccc aaccacgact acatagaaat ccggaatggc ccctatgaga   6120

ccagccgcat gatgggaaga ttcagtggaa gcgagcttcc aagctccctc ctctccacgt   6180

cccacgagac caccgtgtat ttccacagcg accactccca gaatcggcca ggattcaagc   6240

tggagtatca ggatttgact tactcccacc agatttcttc cttcctgaga ggttttgatc   6300

tctcggagtt ggaaagaacc aactcaactc ctcccgtcgc cgcttcctat gtctgggatc   6360

ttgatcctgg ttgtgaagcc tatgaacttc aagagtgccc agacccagag ccctttgcca   6420

atggcattgt gaggggagct ggctacaacg tgggacaatc agtgaccttc gagtgcctcc   6480

cggggtatca attgactggc caccctgtcc tcacgtgtca acatggcacc aaccggaact   6540

gggaccaccc cctgcccaag tgtgaagtcc cttgtggcgg gaacatcact tcttccaacg   6600

gcactgtgta ctccccgggg ttccctagcc cgtactccag ctcccaggac tgtgtctggc   6660

tgatcaccgt gcccattggc catggcgtcc gcctcaacct cagcctgctg cagacagagc   6720

cctctggaga tttcatcacc atctgggatg ggccacagca aacagcacca cggctcggcg   6780

tcttcacccg gagcatggcc aagaaaacag tgcagagttc atccaaccag gtcctgctca   6840

agttccaccg tgatgcagcc acagggggga tcttcgccat agctttctcc gcttatccac   6900

tcaccaaatg ccctcctccc accatcctcc ccaacgccga agtcgtcaca gagaatgaag   6960

aattcaatat aggtgacatc gtacgctaca gatgcctccc tggctttacc ttagtgggga   7020

atgaaattct gacctgcaaa cttggaacct acctgcagtt tgaaggacca cccccgatat   7080

gtgaagtgca ctgtccaaca aatgagcttc tgacagactc cacaggcgtg atcctgagcc   7140

agagctaccc tggaagctat ccccagttcc agacctgctc ttggctggtg agagtggagc   7200

ccgactataa catctccctc acagtggagt acttcctcag cgagaagcaa tatgatgagt   7260

ttgagatttt tgatggtcca tcaggacaga gtcctctgct gaaagccctc agtgggaatt   7320

actcagctcc cctgattgtc accagctcaa gcaactctgt gtacctgcgt tggtcatctg   7380

atcacgccta caatcggaag ggcttcaaga tccgctattc agccccttac tgcagcctgc   7440

ccagggctcc actccatggc ttcatcctag gccagaccag cacccagccc gggggctcca   7500

tccactttgg ctgcaacgcc ggctaccgcc tggtgggaca cagcatggcc atctgtaccc   7560

ggcaccccca gggctaccac ctgtggagcg aagccatccc tctctgtcaa gctctttcct   7620

gtgggcttcc tgaggccccc aagaatggaa tggtgtttgg caaggagtac acagtgggaa   7680

ccaaggccat gtacagctgc agtgaaggct accacctcca ggcaggcgct gaggccactg   7740

cagagtgtct ggacacaggc ctatggagca accgcaatgt cccaccacag tgtgtccctg   7800

tgacttgtcc tgatgtcagt agcatcagcg tggagcatgg ccgatggagg cttatctttg   7860

agacacagta tcagttccag gcccagctga tgctcatctg tgaccctggc tactactata   7920

ctggccaaag ggtcatccgc tgtcaggcca atggcaaatg gagcctcggg gactctacgc   7980

ccacctgccg aatcatctcc tgtggagagc tcccgattcc ccccaatggc caccgcatcg   8040

gaacactgtc tgtctacggg gcaacagcca tcttctcctg caattccgga tacacactgg   8100

tgggctccag ggtgcgtgag tgcatggcca atgggctctg gagtggctct gaagtccgct   8160

gccttgctgg acactgtggg actcctgagc ccattgtcaa cggacacatc aatggggaga   8220

actacagcta ccggggcagt gtggtgtacc aatgcaatgc tggcttccgc ctgatcggca   8280

tgtctgtgcg catctgccag caggatcatc actggtcggg caagacccct ttctgtgtgc   8340

tggtgtcctg tggccatccg ggctccccgc ctcactccca gatgtctgga gacagttata   8400

ctgtgggagc agtggtgcgg tacagctgca tcggcaagcg tactctggtg ggaaacagca   8460

cccgcatgtg tgggctggat ggacactgga ctggctccct ccctcactgc tcaggaacca   8520

gcgtgggagt ttgcggtgac cctgggatcc cggctcatgg catccgtttg ggggacagct   8580

ttgatccagg cactgtgatg cgcttcagct gtgaagctgg ccacgtgctc cggggatcgt   8640

cagagcgcac ctgtcaagcc aatggctcgt ggagcggctc gcagcctgag tgtggagtga   8700

tctcttgtgg gaaccctggg actccaagta atgcccgagt tgtgttcagt gatggcctgg   8760

ttttctccag ctctatcgtc tatgagtgcc gggaaggata ctacgccaca ggcctgctca   8820

gccgtcactg ctcggtcaat ggtacctgga caggcagtga ccctgagtgc ctcgtcataa   8880

actgtggtga ccctgggatt ccagccaatg gccttcggct gggcaatgac ttcaggtaca   8940

acaaaactgt gacatatcag tgtgtccctg gctatatgat ggagtcacat agagtatctg   9000

tgctgagctg caccaaggac cggacatgga atggaaccaa gcccgtctgc aaagctctca   9060

tgtgcaagcc acctccgctc atccccaatg ggaaggtggt ggggtctgac ttcatgtggg   9120

gctcaagtgt gacttatgcc tgcctggagg ggtaccagct ctccctgccc gcggtgttca   9180

cctgtgaggg aaatgggtcc tggaccggag agctgcctca gtgtttccct gtgttctgcg   9240

gggatcctgg tgtcccgtcc cgtgggagga gagaggaccg aggcttctcc tacaggtcat   9300

ctgtctcctt ctcctgccat ccccctctgg tgctggtggg ctctccacgc aggttttgcc   9360

agtcagatgg gacatggagt ggcacccagc ccagctgcat agatccgacc ctgaccacgt   9420

gtgcggaccc tggtgtgcca cagtttggga tacagaacaa ttctcagggc taccaggttg   9480

gaagcacagt cctcttccgt tgtcaaaaag gctacctgct tcagggctcc accaccagga   9540

cctgcctccc aaacctgacc tggagtggaa ccccacctga ctgtgtcccc caccactgca   9600

ggcagccaga gacgccaacg catgccaacg tcggggccct ggatttgccc tccatgggct   9660

acacgctcat ctactcctgc caggagggct tctccctcaa gggtggctcc gagcaccgca   9720

cctgcaaggc ggatggcagc tggacaggca agccgcccat ctgcctggag gtccggccca   9780

gtgggagacc catcaacact gcccgggagc caccgctcac ccaagccttg attcctgggg   9840

atgtttttgc caagaattcc ctgtggaaag gggcctatga ataccagggg aagaagcagc   9900

cagccatgct cagagtgact ggcttccaag ttgccaacag caaggtcaat gccaccatga   9960

tcgaccacag tggcgtggag ctgcacttgg ctggaactta caagaaagaa gattttcatc  10020

tcctactcca ggtgtaccag attacagggc ctgtggagat ctttatgaat aagttcaaag  10080

atgatcactg ggctttagat ggccatgtct cgtcagagtc ctccggagcc accttcatct  10140

accaaggctc tgtcaagggc caaggctttg ggcagttcgg ctttcaaaga ctggacctca  10200

ggctgctgga gtcagacccc gagtccattg gccgccactt tgcttccaac agcagctcag  10260

tggcagccgc gatcctggtg cctttcatcg ccctcattat tgcgggcttc gtgctctatc  10320

tctacaagca caggagaaga cccaaagttc ctttcaatgg ctatgctggc cacgagaaca  10380

ccaatgttcg ggccacattt gagaacccaa tgtacgaccg caacatccag cccacagaca  10440

tcatggccag cgaggcggag ttcacagtca gcacagtgtg cacagcagta tagccacccg  10500

gcctggccgc caccaccgcc accgagagcc ccgcctccag cagccgttcc ccagggggca  10560

ggaagtaggc tcccctgagc acagtgccca gtgcccatct tcgttcgtct ccttgcctgt  10620

gtctgctact gctgggactc aggccctcgc cctgccgcca tctatgccag ttaccctgga  10680

gaggactcct gccgtgtcct gaaaaggcag aaaaggaaga ggggctgcag acagaggaag  10740

aaagtttatg gatttaaaat agcaaagcaa cttgtggatc tgtgtgtgtg tgtgtgtgta  10800

tgggcctgat cacacacaaa cacacacacc tctccttcat tcacgtccta tggaagagac  10860

cataaaggct tcaaaactag aagtgcgcat gaaggatgct tcatgccctg ttccccacac  10920

agagaagaga tgaagagggg gaggtacggt cagctttcaa aacaatatgc cccccgccca  10980

tcccatgtgt gaggacatgg tgactcggtg actgtaacag taggacacat cccatcatgc  11040

ggtcagagtg cagaaacccg gtcagcgtgc agaaaccagc tgtctgctga tgaacggccc  11100

atctgcacag cggcagcaag gattacccca agggcaggaa aaaagtcttt ggaaatagat  11160

tgaaaatcag tttctttatt tttttcaaac actgttttat tgagttctaa acccagtgga  11220

ttaaaaagtc atttgggtcc tgggaagcac tgggaaagaa gggagagccg gggaggatag  11280

ggcaggagtc tggccaggag cccaaggtca agtctggctg tcaactgaca aagagaagag  11340

aagacaagtc tgtggcccag acaggatgcc aagtctgggg gcagcagcag ggtccttgag  11400

agaacagggg agcaagcctg ccccagtacc caaaaaacaa tggctatcat gtactggggt  11460

tattctctgt gcctgacact ttacctgtag tatttctagt ctgcacaata acaccaaaat  11520

gtaggatttg ttattcccct ttgacagatg agaaaacaga agcctgcaaa ggtaaagaca  11580

gagttaggaa gtgtggagtc agaatgcaaa cccagatcag tctgccccaa agtccactac  11640

accagctgcc agaaaccctg ttctagaagg ggcagctaag aagggaggag ccgatgaatc  11700

tctacagtag cactgtggcc aggtctggaa agccaggcaa gacacctgtg tgtcctatct  11760

gggttctgct gtctccgcgt aggcagcttc ggggcaagga ttcaactccc caggcctccc  11820

acggttggtg ctggctcctt ggctcccagc agccgctgac catagccagc aaaagacctg  11880

gcaggtcctg aatcaaaaca acagagtggc tgaaagtcac acctctccag ctccttgcga  11940

gtgggtttga ttgattttga cagctatatc atgcttgggt cgttcatgaa ttccatgaga  12000

attgttggga agttcatgag tttaggaatc aaagtatagc atttagggcc actttctctg  12060

tcctcgggaa ggcccccaca agcttaagcc cctgtatacg tgtgacatgc tggcctcaga  12120

gattcatgtc acatattgaa atagcaaata gaaatgtgca ggagcggagg gacagcgaca  12180

cctggttctt aagcaaattc tagattggaa caattagaag atctgactga tgttaagagt  12240

ggccagagga aagtgagagg cgtccatttc cagcagacac aatggaggct gacagaggca  12300

ggagcctacc cctggccaca ccacctctgg gacacggcac ccccctgggc ctggagggag  12360

agggccaatc cagacacact cacactctca tctctttcct tggctggaaa caagtgcagg  12420

aagctcccct cccaatttct tatgctccct tcccccttac actcctctcc ttcgactgct  12480

cccttccccc ttcttatgcc cctctcagac cacccagcgg atgcctattc ccgcccccca  12540

cccctcccct gcgtctcctt gtaaagttcc atgagatgct cgaggagcac ctgctggtgg  12600

ggcacccagc actctgctgg gcatcaccct ccgcacccct gacatttctc tccacctcca  12660

gaggcttgga agggaacagg gcagatgagg cccttcaccc accatctacg ccatataccc  12720

atcaccatcc catgaggaaa aaaaaaaaag taaaacaaag acaaaaaaaa tcttttgtac  12780

agagatatat ttttattata caaagtttgt acagtaccaa aaaagaaaaa aaaaaaggtg  12840

taaatttttt tttcattatt gtaggtaaac ggtagtggaa gccttttttg taaatgtaat  12900

aaaatgtata aatatggttt tcagaaaaca tcaagtgctg taaatatgta atctacacac  12960

cttcttggct tgtctgcagt atatacattt aatttatctg tctctgtata tgaggcttcc  13020

ccctggggtc ctgcattatg gtactttcct gaatttgaaa gcaattttaa attttttgaa  13080

ttcaaataaa atataaattt ttgcattg                                     13108


<210>  78
<211>  3487
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Arg Leu Ile Ser Ile Ala Pro Gly Pro Arg Trp Gln Val Gln Ser 
1               5                   10                  15


His His Pro Arg Ser Ala Gly Gln Asn Cys Thr Phe Gln Leu His Gly 
            20                  25                  30


Pro Asn Gly Thr Val Glu Ser Pro Gly Phe Pro Tyr Gly Tyr Pro Asn 
        35                  40                  45


Tyr Ala Asn Cys Thr Trp Thr Ile Thr Ala Glu Glu Gln His Arg Ile 
    50                  55                  60


Gln Leu Val Phe Gln Ser Phe Ala Leu Glu Glu Asp Phe Asp Val Leu 
65                  70                  75                  80


Ser Val Phe Asp Gly Pro Pro Gln Pro Glu Asn Leu Arg Thr Arg Leu 
                85                  90                  95


Thr Gly Phe Gln Leu Pro Ala Thr Ile Val Ser Ala Ala Thr Thr Leu 
            100                 105                 110


Ser Leu Arg Leu Ile Ser Asp Tyr Ala Val Ser Ala Gln Gly Phe His 
        115                 120                 125


Ala Thr Tyr Glu Val Leu Pro Ser His Thr Cys Gly Asn Pro Gly Arg 
    130                 135                 140


Leu Pro Asn Gly Ile Gln Gln Gly Ser Thr Phe Asn Leu Gly Asp Lys 
145                 150                 155                 160


Val Arg Tyr Ser Cys Asn Leu Gly Phe Phe Leu Glu Gly His Ala Val 
                165                 170                 175


Leu Thr Cys His Ala Gly Ser Glu Asn Ser Ala Thr Trp Asp Phe Pro 
            180                 185                 190


Leu Pro Ser Cys Arg Ala Asp Asp Ala Cys Gly Gly Thr Leu Arg Gly 
        195                 200                 205


Gln Ser Gly Ile Ile Ser Ser Pro His Phe Pro Ser Glu Tyr His Asn 
    210                 215                 220


Asn Ala Asp Cys Thr Trp Thr Ile Leu Ala Glu Leu Gly Asp Thr Ile 
225                 230                 235                 240


Ala Leu Val Phe Ile Asp Phe Gln Leu Glu Asp Gly Tyr Asp Phe Leu 
                245                 250                 255


Glu Val Thr Gly Thr Glu Gly Ser Ser Leu Trp Phe Thr Gly Ala Ser 
            260                 265                 270


Leu Pro Ala Pro Val Ile Ser Ser Lys Asn Trp Leu Arg Leu His Phe 
        275                 280                 285


Thr Ser Asp Gly Asn His Arg Gln Arg Gly Phe Ser Ala Gln Tyr Gln 
    290                 295                 300


Val Lys Lys Gln Ile Glu Leu Lys Ser Arg Gly Val Lys Leu Met Pro 
305                 310                 315                 320


Ser Lys Asp Asn Ser Gln Lys Thr Ser Val Leu Thr Gln Val Gly Val 
                325                 330                 335


Ser Gln Gly His Asn Met Cys Pro Asp Pro Gly Ile Pro Glu Arg Gly 
            340                 345                 350


Lys Arg Leu Gly Ser Asp Phe Arg Leu Gly Ser Ser Val Gln Phe Thr 
        355                 360                 365


Cys Asn Glu Gly Tyr Asp Leu Gln Gly Ser Lys Arg Ile Thr Cys Met 
    370                 375                 380


Lys Val Ser Asp Met Phe Ala Ala Trp Ser Asp His Arg Pro Val Cys 
385                 390                 395                 400


Arg Ala Arg Met Cys Asp Ala His Leu Arg Gly Pro Ser Gly Ile Ile 
                405                 410                 415


Thr Ser Pro Asn Phe Pro Ile Gln Tyr Asp Asn Asn Ala His Cys Val 
            420                 425                 430


Trp Ile Ile Thr Ala Leu Asn Pro Ser Lys Val Ile Lys Leu Ala Phe 
        435                 440                 445


Glu Glu Phe Asp Leu Glu Arg Gly Tyr Asp Thr Leu Thr Val Gly Asp 
    450                 455                 460


Gly Gly Gln Asp Gly Asp Gln Lys Thr Val Leu Tyr Ile Leu Thr Gly 
465                 470                 475                 480


Thr Ser Val Pro Asp Leu Ile Val Ser Thr Asn His Gln Met Trp Leu 
                485                 490                 495


Leu Phe Gln Thr Asp Gly Ser Gly Ser Ser Leu Gly Phe Lys Ala Ser 
            500                 505                 510


Tyr Glu Glu Ile Glu Gln Gly Ser Cys Gly Asp Pro Gly Ile Pro Ala 
        515                 520                 525


Tyr Gly Arg Arg Glu Gly Ser Arg Phe His His Gly Asp Thr Leu Lys 
    530                 535                 540


Phe Glu Cys Gln Pro Ala Phe Glu Leu Val Gly Gln Lys Ala Ile Thr 
545                 550                 555                 560


Cys Gln Lys Asn Asn Gln Trp Ser Ala Lys Lys Pro Gly Cys Val Phe 
                565                 570                 575


Ser Cys Phe Phe Asn Phe Thr Ser Pro Ser Gly Val Val Leu Ser Pro 
            580                 585                 590


Asn Tyr Pro Glu Asp Tyr Gly Asn His Leu His Cys Val Trp Leu Ile 
        595                 600                 605


Leu Ala Arg Pro Glu Ser Arg Ile His Leu Ala Phe Asn Asp Ile Asp 
    610                 615                 620


Val Glu Pro Gln Phe Asp Phe Leu Val Ile Lys Asp Gly Ala Thr Ala 
625                 630                 635                 640


Glu Ala Pro Val Leu Gly Thr Phe Ser Gly Asn Gln Leu Pro Ser Ser 
                645                 650                 655


Ile Thr Ser Ser Gly His Val Ala Arg Leu Glu Phe Gln Thr Asp His 
            660                 665                 670


Ser Thr Gly Lys Arg Gly Phe Asn Ile Thr Phe Thr Thr Phe Arg His 
        675                 680                 685


Asn Glu Cys Pro Asp Pro Gly Val Pro Val Asn Gly Lys Arg Phe Gly 
    690                 695                 700


Asp Ser Leu Gln Leu Gly Ser Ser Ile Ser Phe Leu Cys Asp Glu Gly 
705                 710                 715                 720


Phe Leu Gly Thr Gln Gly Ser Glu Thr Ile Thr Cys Val Leu Lys Glu 
                725                 730                 735


Gly Ser Val Val Trp Asn Ser Ala Val Leu Arg Cys Glu Ala Pro Cys 
            740                 745                 750


Gly Gly His Leu Thr Ser Pro Ser Gly Thr Ile Leu Ser Pro Gly Trp 
        755                 760                 765


Pro Gly Phe Tyr Lys Asp Ala Leu Ser Cys Ala Trp Val Ile Glu Ala 
    770                 775                 780


Gln Pro Gly Tyr Pro Ile Lys Ile Thr Phe Asp Arg Phe Lys Thr Glu 
785                 790                 795                 800


Val Asn Tyr Asp Thr Leu Glu Val Arg Asp Gly Arg Thr Tyr Ser Ala 
                805                 810                 815


Pro Leu Ile Gly Val Tyr His Gly Thr Gln Val Pro Gln Phe Leu Ile 
            820                 825                 830


Ser Thr Ser Asn Tyr Leu Tyr Leu Leu Phe Ser Thr Asp Lys Ser His 
        835                 840                 845


Ser Asp Ile Gly Phe Gln Leu Arg Tyr Glu Thr Ile Thr Leu Gln Ser 
    850                 855                 860


Asp His Cys Leu Asp Pro Gly Ile Pro Val Asn Gly Gln Arg His Gly 
865                 870                 875                 880


Asn Asp Phe Tyr Val Gly Ala Leu Val Thr Phe Ser Cys Asp Ser Gly 
                885                 890                 895


Tyr Thr Leu Ser Asp Gly Glu Pro Leu Glu Cys Glu Pro Asn Phe Gln 
            900                 905                 910


Trp Ser Arg Ala Leu Pro Ser Cys Glu Ala Leu Cys Gly Gly Phe Ile 
        915                 920                 925


Gln Gly Ser Ser Gly Thr Ile Leu Ser Pro Gly Phe Pro Asp Phe Tyr 
    930                 935                 940


Pro Asn Asn Leu Asn Cys Thr Trp Ile Ile Glu Thr Ser His Gly Lys 
945                 950                 955                 960


Gly Val Phe Phe Thr Phe His Thr Phe His Leu Glu Ser Gly His Asp 
                965                 970                 975


Tyr Leu Leu Ile Thr Glu Asn Gly Ser Phe Thr Gln Pro Leu Arg Gln 
            980                 985                 990


Leu Thr Gly Ser Arg Leu Pro Ala Pro Ile Ser Ala Gly Leu Tyr Gly 
        995                 1000                1005


Asn Phe Thr Ala Gln Val Arg Phe Ile Ser Asp Phe Ser Met Ser Tyr 
    1010                1015                1020


Glu Gly Phe Asn Ile Thr Phe Ser Glu Tyr Asp Leu Glu Pro Cys Glu 
1025                1030                1035                1040


Glu Pro Glu Val Pro Ala Tyr Ser Ile Arg Lys Gly Leu Gln Phe Gly 
                1045                1050                1055


Val Gly Asp Thr Leu Thr Phe Ser Cys Phe Pro Gly Tyr Arg Leu Glu 
            1060                1065                1070


Gly Thr Ala Arg Ile Thr Cys Leu Gly Gly Arg Arg Arg Leu Trp Ser 
        1075                1080                1085


Ser Pro Leu Pro Arg Cys Val Ala Glu Cys Gly Asn Ser Val Thr Gly 
    1090                1095                1100


Thr Gln Gly Thr Leu Leu Ser Pro Asn Phe Pro Val Asn Tyr Asn Asn 
1105                1110                1115                1120


Asn His Glu Cys Ile Tyr Ser Ile Gln Thr Gln Pro Gly Lys Gly Ile 
                1125                1130                1135


Gln Leu Lys Ala Arg Ala Phe Glu Leu Ser Glu Gly Asp Val Leu Lys 
            1140                1145                1150


Val Tyr Asp Gly Asn Asn Asn Ser Ala Arg Leu Leu Gly Val Phe Ser 
        1155                1160                1165


His Ser Glu Met Met Gly Val Thr Leu Asn Ser Thr Ser Ser Ser Leu 
    1170                1175                1180


Trp Leu Asp Phe Ile Thr Asp Ala Glu Asn Thr Ser Lys Gly Phe Glu 
1185                1190                1195                1200


Leu His Phe Ser Ser Phe Glu Leu Ile Lys Cys Glu Asp Pro Gly Thr 
                1205                1210                1215


Pro Lys Phe Gly Tyr Lys Val His Asp Glu Gly His Phe Ala Gly Ser 
            1220                1225                1230


Ser Val Ser Phe Ser Cys Asp Pro Gly Tyr Ser Leu Arg Gly Ser Glu 
        1235                1240                1245


Glu Leu Leu Cys Leu Ser Gly Glu Arg Arg Thr Trp Asp Arg Pro Leu 
    1250                1255                1260


Pro Thr Cys Val Ala Glu Cys Gly Gly Thr Val Arg Gly Glu Val Ser 
1265                1270                1275                1280


Gly Gln Val Leu Ser Pro Gly Tyr Pro Ala Pro Tyr Glu His Asn Leu 
                1285                1290                1295


Asn Cys Ile Trp Thr Ile Glu Ala Glu Ala Gly Cys Thr Ile Gly Leu 
            1300                1305                1310


His Phe Leu Val Phe Asp Thr Glu Glu Val His Asp Val Leu Arg Ile 
        1315                1320                1325


Trp Asp Gly Pro Val Glu Ser Gly Val Leu Leu Lys Glu Leu Ser Gly 
    1330                1335                1340


Pro Ala Leu Pro Lys Asp Leu His Ser Thr Phe Asn Ser Val Val Leu 
1345                1350                1355                1360


Gln Phe Ser Thr Asp Phe Phe Thr Ser Lys Gln Gly Phe Ala Ile Gln 
                1365                1370                1375


Phe Ser Val Ser Thr Ala Thr Ser Cys Asn Asp Pro Gly Ile Pro Gln 
            1380                1385                1390


Asn Gly Ser Arg Ser Gly Asp Ser Trp Glu Ala Gly Asp Ser Thr Val 
        1395                1400                1405


Phe Gln Cys Asp Pro Gly Tyr Ala Leu Gln Gly Ser Ala Glu Ile Ser 
    1410                1415                1420


Cys Val Lys Ile Glu Asn Arg Phe Phe Trp Gln Pro Ser Pro Pro Thr 
1425                1430                1435                1440


Cys Ile Ala Pro Cys Gly Gly Asp Leu Thr Gly Pro Ser Gly Val Ile 
                1445                1450                1455


Leu Ser Pro Asn Tyr Pro Glu Pro Tyr Pro Pro Gly Lys Glu Cys Asp 
            1460                1465                1470


Trp Lys Val Thr Val Ser Pro Asp Tyr Val Ile Ala Leu Val Phe Asn 
        1475                1480                1485


Ile Phe Asn Leu Glu Pro Gly Tyr Asp Phe Leu His Ile Tyr Asp Gly 
    1490                1495                1500


Arg Asp Ser Leu Ser Pro Leu Ile Gly Ser Phe Tyr Gly Ser Gln Leu 
1505                1510                1515                1520


Pro Gly Arg Ile Glu Ser Ser Ser Asn Ser Leu Phe Leu Ala Phe Arg 
                1525                1530                1535


Ser Asp Ala Ser Val Ser Asn Ala Gly Phe Val Ile Asp Tyr Thr Glu 
            1540                1545                1550


Asn Pro Arg Glu Ser Cys Phe Asp Pro Gly Ser Ile Lys Asn Gly Thr 
        1555                1560                1565


Arg Val Gly Ser Asp Leu Lys Leu Gly Ser Ser Val Thr Tyr Tyr Cys 
    1570                1575                1580


His Gly Gly Tyr Glu Val Glu Gly Thr Ser Thr Leu Ser Cys Ile Leu 
1585                1590                1595                1600


Gly Pro Asp Gly Lys Pro Val Trp Asn Asn Pro Arg Pro Val Cys Thr 
                1605                1610                1615


Ala Pro Cys Gly Gly Gln Tyr Val Gly Ser Asp Gly Val Val Leu Ser 
            1620                1625                1630


Pro Asn Tyr Pro Gln Asn Tyr Thr Ser Gly Gln Ile Cys Leu Tyr Phe 
        1635                1640                1645


Val Thr Val Pro Lys Asp Tyr Val Val Phe Gly Gln Phe Ala Phe Phe 
    1650                1655                1660


His Thr Ala Leu Asn Asp Val Val Glu Val His Asp Gly His Ser Gln 
1665                1670                1675                1680


His Ser Arg Leu Leu Ser Ser Leu Ser Gly Ser His Thr Gly Glu Ser 
                1685                1690                1695


Leu Pro Leu Ala Thr Ser Asn Gln Val Leu Ile Lys Phe Ser Ala Lys 
            1700                1705                1710


Gly Leu Ala Pro Ala Arg Gly Phe His Phe Val Tyr Gln Ala Val Pro 
        1715                1720                1725


Arg Thr Ser Ala Thr Gln Cys Ser Ser Val Pro Glu Pro Arg Tyr Gly 
    1730                1735                1740


Lys Arg Leu Gly Ser Asp Phe Ser Val Gly Ala Ile Val Arg Phe Glu 
1745                1750                1755                1760


Cys Asn Ser Gly Tyr Ala Leu Gln Gly Ser Pro Glu Ile Glu Cys Leu 
                1765                1770                1775


Pro Val Pro Gly Ala Leu Ala Gln Trp Asn Val Ser Ala Pro Thr Cys 
            1780                1785                1790


Val Val Pro Cys Gly Gly Asn Leu Thr Glu Arg Arg Gly Thr Ile Leu 
        1795                1800                1805


Ser Pro Gly Phe Pro Glu Pro Tyr Leu Asn Ser Leu Asn Cys Val Trp 
    1810                1815                1820


Lys Ile Val Val Pro Glu Gly Ala Gly Ile Gln Ile Gln Val Val Ser 
1825                1830                1835                1840


Phe Val Thr Glu Gln Asn Trp Asp Ser Leu Glu Val Phe Asp Gly Ala 
                1845                1850                1855


Asp Asn Thr Val Thr Met Leu Gly Ser Phe Ser Gly Thr Thr Val Pro 
            1860                1865                1870


Ala Leu Leu Asn Ser Thr Ser Asn Gln Leu Tyr Leu His Phe Tyr Ser 
        1875                1880                1885


Asp Ile Ser Val Ser Ala Ala Gly Phe His Leu Glu Tyr Lys Thr Val 
    1890                1895                1900


Gly Leu Ser Ser Cys Pro Glu Pro Ala Val Pro Ser Asn Gly Val Lys 
1905                1910                1915                1920


Thr Gly Glu Arg Tyr Leu Val Asn Asp Val Val Ser Phe Gln Cys Glu 
                1925                1930                1935


Pro Gly Tyr Ala Leu Gln Gly His Ala His Ile Ser Cys Met Pro Gly 
            1940                1945                1950


Thr Val Arg Arg Trp Asn Tyr Pro Pro Pro Leu Cys Ile Ala Gln Cys 
        1955                1960                1965


Gly Gly Thr Val Glu Glu Met Glu Gly Val Ile Leu Ser Pro Gly Phe 
    1970                1975                1980


Pro Gly Asn Tyr Pro Ser Asn Met Asp Cys Ser Trp Lys Ile Ala Leu 
1985                1990                1995                2000


Pro Val Gly Phe Gly Ala His Ile Gln Phe Leu Asn Phe Ser Thr Glu 
                2005                2010                2015


Pro Asn His Asp Tyr Ile Glu Ile Arg Asn Gly Pro Tyr Glu Thr Ser 
            2020                2025                2030


Arg Met Met Gly Arg Phe Ser Gly Ser Glu Leu Pro Ser Ser Leu Leu 
        2035                2040                2045


Ser Thr Ser His Glu Thr Thr Val Tyr Phe His Ser Asp His Ser Gln 
    2050                2055                2060


Asn Arg Pro Gly Phe Lys Leu Glu Tyr Gln Asp Leu Thr Tyr Ser His 
2065                2070                2075                2080


Gln Ile Ser Ser Phe Leu Arg Gly Phe Asp Leu Ser Glu Leu Glu Arg 
                2085                2090                2095


Thr Asn Ser Thr Pro Pro Val Ala Ala Ser Tyr Val Trp Asp Leu Asp 
            2100                2105                2110


Pro Gly Cys Glu Ala Tyr Glu Leu Gln Glu Cys Pro Asp Pro Glu Pro 
        2115                2120                2125


Phe Ala Asn Gly Ile Val Arg Gly Ala Gly Tyr Asn Val Gly Gln Ser 
    2130                2135                2140


Val Thr Phe Glu Cys Leu Pro Gly Tyr Gln Leu Thr Gly His Pro Val 
2145                2150                2155                2160


Leu Thr Cys Gln His Gly Thr Asn Arg Asn Trp Asp His Pro Leu Pro 
                2165                2170                2175


Lys Cys Glu Val Pro Cys Gly Gly Asn Ile Thr Ser Ser Asn Gly Thr 
            2180                2185                2190


Val Tyr Ser Pro Gly Phe Pro Ser Pro Tyr Ser Ser Ser Gln Asp Cys 
        2195                2200                2205


Val Trp Leu Ile Thr Val Pro Ile Gly His Gly Val Arg Leu Asn Leu 
    2210                2215                2220


Ser Leu Leu Gln Thr Glu Pro Ser Gly Asp Phe Ile Thr Ile Trp Asp 
2225                2230                2235                2240


Gly Pro Gln Gln Thr Ala Pro Arg Leu Gly Val Phe Thr Arg Ser Met 
                2245                2250                2255


Ala Lys Lys Thr Val Gln Ser Ser Ser Asn Gln Val Leu Leu Lys Phe 
            2260                2265                2270


His Arg Asp Ala Ala Thr Gly Gly Ile Phe Ala Ile Ala Phe Ser Ala 
        2275                2280                2285


Tyr Pro Leu Thr Lys Cys Pro Pro Pro Thr Ile Leu Pro Asn Ala Glu 
    2290                2295                2300


Val Val Thr Glu Asn Glu Glu Phe Asn Ile Gly Asp Ile Val Arg Tyr 
2305                2310                2315                2320


Arg Cys Leu Pro Gly Phe Thr Leu Val Gly Asn Glu Ile Leu Thr Cys 
                2325                2330                2335


Lys Leu Gly Thr Tyr Leu Gln Phe Glu Gly Pro Pro Pro Ile Cys Glu 
            2340                2345                2350


Val His Cys Pro Thr Asn Glu Leu Leu Thr Asp Ser Thr Gly Val Ile 
        2355                2360                2365


Leu Ser Gln Ser Tyr Pro Gly Ser Tyr Pro Gln Phe Gln Thr Cys Ser 
    2370                2375                2380


Trp Leu Val Arg Val Glu Pro Asp Tyr Asn Ile Ser Leu Thr Val Glu 
2385                2390                2395                2400


Tyr Phe Leu Ser Glu Lys Gln Tyr Asp Glu Phe Glu Ile Phe Asp Gly 
                2405                2410                2415


Pro Ser Gly Gln Ser Pro Leu Leu Lys Ala Leu Ser Gly Asn Tyr Ser 
            2420                2425                2430


Ala Pro Leu Ile Val Thr Ser Ser Ser Asn Ser Val Tyr Leu Arg Trp 
        2435                2440                2445


Ser Ser Asp His Ala Tyr Asn Arg Lys Gly Phe Lys Ile Arg Tyr Ser 
    2450                2455                2460


Ala Pro Tyr Cys Ser Leu Pro Arg Ala Pro Leu His Gly Phe Ile Leu 
2465                2470                2475                2480


Gly Gln Thr Ser Thr Gln Pro Gly Gly Ser Ile His Phe Gly Cys Asn 
                2485                2490                2495


Ala Gly Tyr Arg Leu Val Gly His Ser Met Ala Ile Cys Thr Arg His 
            2500                2505                2510


Pro Gln Gly Tyr His Leu Trp Ser Glu Ala Ile Pro Leu Cys Gln Ala 
        2515                2520                2525


Leu Ser Cys Gly Leu Pro Glu Ala Pro Lys Asn Gly Met Val Phe Gly 
    2530                2535                2540


Lys Glu Tyr Thr Val Gly Thr Lys Ala Met Tyr Ser Cys Ser Glu Gly 
2545                2550                2555                2560


Tyr His Leu Gln Ala Gly Ala Glu Ala Thr Ala Glu Cys Leu Asp Thr 
                2565                2570                2575


Gly Leu Trp Ser Asn Arg Asn Val Pro Pro Gln Cys Val Pro Val Thr 
            2580                2585                2590


Cys Pro Asp Val Ser Ser Ile Ser Val Glu His Gly Arg Trp Arg Leu 
        2595                2600                2605


Ile Phe Glu Thr Gln Tyr Gln Phe Gln Ala Gln Leu Met Leu Ile Cys 
    2610                2615                2620


Asp Pro Gly Tyr Tyr Tyr Thr Gly Gln Arg Val Ile Arg Cys Gln Ala 
2625                2630                2635                2640


Asn Gly Lys Trp Ser Leu Gly Asp Ser Thr Pro Thr Cys Arg Ile Ile 
                2645                2650                2655


Ser Cys Gly Glu Leu Pro Ile Pro Pro Asn Gly His Arg Ile Gly Thr 
            2660                2665                2670


Leu Ser Val Tyr Gly Ala Thr Ala Ile Phe Ser Cys Asn Ser Gly Tyr 
        2675                2680                2685


Thr Leu Val Gly Ser Arg Val Arg Glu Cys Met Ala Asn Gly Leu Trp 
    2690                2695                2700


Ser Gly Ser Glu Val Arg Cys Leu Ala Gly His Cys Gly Thr Pro Glu 
2705                2710                2715                2720


Pro Ile Val Asn Gly His Ile Asn Gly Glu Asn Tyr Ser Tyr Arg Gly 
                2725                2730                2735


Ser Val Val Tyr Gln Cys Asn Ala Gly Phe Arg Leu Ile Gly Met Ser 
            2740                2745                2750


Val Arg Ile Cys Gln Gln Asp His His Trp Ser Gly Lys Thr Pro Phe 
        2755                2760                2765


Cys Val Leu Val Ser Cys Gly His Pro Gly Ser Pro Pro His Ser Gln 
    2770                2775                2780


Met Ser Gly Asp Ser Tyr Thr Val Gly Ala Val Val Arg Tyr Ser Cys 
2785                2790                2795                2800


Ile Gly Lys Arg Thr Leu Val Gly Asn Ser Thr Arg Met Cys Gly Leu 
                2805                2810                2815


Asp Gly His Trp Thr Gly Ser Leu Pro His Cys Ser Gly Thr Ser Val 
            2820                2825                2830


Gly Val Cys Gly Asp Pro Gly Ile Pro Ala His Gly Ile Arg Leu Gly 
        2835                2840                2845


Asp Ser Phe Asp Pro Gly Thr Val Met Arg Phe Ser Cys Glu Ala Gly 
    2850                2855                2860


His Val Leu Arg Gly Ser Ser Glu Arg Thr Cys Gln Ala Asn Gly Ser 
2865                2870                2875                2880


Trp Ser Gly Ser Gln Pro Glu Cys Gly Val Ile Ser Cys Gly Asn Pro 
                2885                2890                2895


Gly Thr Pro Ser Asn Ala Arg Val Val Phe Ser Asp Gly Leu Val Phe 
            2900                2905                2910


Ser Ser Ser Ile Val Tyr Glu Cys Arg Glu Gly Tyr Tyr Ala Thr Gly 
        2915                2920                2925


Leu Leu Ser Arg His Cys Ser Val Asn Gly Thr Trp Thr Gly Ser Asp 
    2930                2935                2940


Pro Glu Cys Leu Val Ile Asn Cys Gly Asp Pro Gly Ile Pro Ala Asn 
2945                2950                2955                2960


Gly Leu Arg Leu Gly Asn Asp Phe Arg Tyr Asn Lys Thr Val Thr Tyr 
                2965                2970                2975


Gln Cys Val Pro Gly Tyr Met Met Glu Ser His Arg Val Ser Val Leu 
            2980                2985                2990


Ser Cys Thr Lys Asp Arg Thr Trp Asn Gly Thr Lys Pro Val Cys Lys 
        2995                3000                3005


Ala Leu Met Cys Lys Pro Pro Pro Leu Ile Pro Asn Gly Lys Val Val 
    3010                3015                3020


Gly Ser Asp Phe Met Trp Gly Ser Ser Val Thr Tyr Ala Cys Leu Glu 
3025                3030                3035                3040


Gly Tyr Gln Leu Ser Leu Pro Ala Val Phe Thr Cys Glu Gly Asn Gly 
                3045                3050                3055


Ser Trp Thr Gly Glu Leu Pro Gln Cys Phe Pro Val Phe Cys Gly Asp 
            3060                3065                3070


Pro Gly Val Pro Ser Arg Gly Arg Arg Glu Asp Arg Gly Phe Ser Tyr 
        3075                3080                3085


Arg Ser Ser Val Ser Phe Ser Cys His Pro Pro Leu Val Leu Val Gly 
    3090                3095                3100


Ser Pro Arg Arg Phe Cys Gln Ser Asp Gly Thr Trp Ser Gly Thr Gln 
3105                3110                3115                3120


Pro Ser Cys Ile Asp Pro Thr Leu Thr Thr Cys Ala Asp Pro Gly Val 
                3125                3130                3135


Pro Gln Phe Gly Ile Gln Asn Asn Ser Gln Gly Tyr Gln Val Gly Ser 
            3140                3145                3150


Thr Val Leu Phe Arg Cys Gln Lys Gly Tyr Leu Leu Gln Gly Ser Thr 
        3155                3160                3165


Thr Arg Thr Cys Leu Pro Asn Leu Thr Trp Ser Gly Thr Pro Pro Asp 
    3170                3175                3180


Cys Val Pro His His Cys Arg Gln Pro Glu Thr Pro Thr His Ala Asn 
3185                3190                3195                3200


Val Gly Ala Leu Asp Leu Pro Ser Met Gly Tyr Thr Leu Ile Tyr Ser 
                3205                3210                3215


Cys Gln Glu Gly Phe Ser Leu Lys Gly Gly Ser Glu His Arg Thr Cys 
            3220                3225                3230


Lys Ala Asp Gly Ser Trp Thr Gly Lys Pro Pro Ile Cys Leu Glu Val 
        3235                3240                3245


Arg Pro Ser Gly Arg Pro Ile Asn Thr Ala Arg Glu Pro Pro Leu Thr 
    3250                3255                3260


Gln Ala Leu Ile Pro Gly Asp Val Phe Ala Lys Asn Ser Leu Trp Lys 
3265                3270                3275                3280


Gly Ala Tyr Glu Tyr Gln Gly Lys Lys Gln Pro Ala Met Leu Arg Val 
                3285                3290                3295


Thr Gly Phe Gln Val Ala Asn Ser Lys Val Asn Ala Thr Met Ile Asp 
            3300                3305                3310


His Ser Gly Val Glu Leu His Leu Ala Gly Thr Tyr Lys Lys Glu Asp 
        3315                3320                3325


Phe His Leu Leu Leu Gln Val Tyr Gln Ile Thr Gly Pro Val Glu Ile 
    3330                3335                3340


Phe Met Asn Lys Phe Lys Asp Asp His Trp Ala Leu Asp Gly His Val 
3345                3350                3355                3360


Ser Ser Glu Ser Ser Gly Ala Thr Phe Ile Tyr Gln Gly Ser Val Lys 
                3365                3370                3375


Gly Gln Gly Phe Gly Gln Phe Gly Phe Gln Arg Leu Asp Leu Arg Leu 
            3380                3385                3390


Leu Glu Ser Asp Pro Glu Ser Ile Gly Arg His Phe Ala Ser Asn Ser 
        3395                3400                3405


Ser Ser Val Ala Ala Ala Ile Leu Val Pro Phe Ile Ala Leu Ile Ile 
    3410                3415                3420


Ala Gly Phe Val Leu Tyr Leu Tyr Lys His Arg Arg Arg Pro Lys Val 
3425                3430                3435                3440


Pro Phe Asn Gly Tyr Ala Gly His Glu Asn Thr Asn Val Arg Ala Thr 
                3445                3450                3455


Phe Glu Asn Pro Met Tyr Asp Arg Asn Ile Gln Pro Thr Asp Ile Met 
            3460                3465                3470


Ala Ser Glu Ala Glu Phe Thr Val Ser Thr Val Cys Thr Ala Val 
        3475                3480                3485


<210>  79
<211>  2580
<212>  DNA
<213>  Homo sapiens

<400>  79
ataaggtatg aaagatgtgg cctgcagaga gccggcacta tctctactgc tgctgctgct     60

gctactgctg ctgttgctac cgctgcctct gctgccaccg ccactactgc tgccagcgga    120

gccgctagga gtgagcatcc cctctccggg atacccagct ccgcggcgtc tcccgcgcgc    180

cctggcccca cacggacctg ccagccccag ggaacaaaag cggagcccgc tcgccctcta    240

ctgcagccgg aggatgagtc gagagggctg agcggagagt gtggtcctcg gcggctggag    300

ctatttcctt ggcttctctc catgacgatt cctgactcgt ggccccggca atcttgggaa    360

gacatcatcc agcttcttca gtccagaccc tgggcacccc ccttttgcca ggatcgtccc    420

cacccagcct ggacacattg actgaactgt tttctaggac actgcactca gcaagacatg    480

gtggtgagcc ctgactctca gtcttcatga ttgaagaact cttttgtaca acacaaagca    540

ctcaaaaaga gtgaatgaaa tgtgcagctc agagtgtcat ttctgaaggg aggagtcttt    600

ctcttggaga agagtcctca atgagcctgg ccgaggcccg ggatctgtgt gaagtggact    660

aaggattaag taggatgtca actgagacag aacttcaagt agctgtgaaa accagcgcca    720

agaaagactc cagaaagaaa ggtcaggatc gcagtgaagc cactttgata aagaggttta    780

aaggtgaagg ggtccggtac aaagccaaat tgatcgggat tgatgaagtt tccgcagctc    840

ggggagacaa gttatgtcaa gattccatga tgaaactcaa gggcgttgtt gctggcgctc    900

gttccaaagg agaacacaaa cagaaaatct ttttaaccat ctcctttgga ggaatcaaaa    960

tctttgatga gaagacaggg gcccttcagc atcatcatgc tgttcatgaa atatcctaca   1020

ttgcaaagga cattacagat caccgggcct ttggatatgt ttgtgggaag gaagggaatc   1080

acagatttgt ggccataaaa acagcccagg cggctgaacc tgttattctg gacttgagag   1140

atctctttca actcatttat gaattgaagc aaagagaaga attagaaaaa aaggcacaaa   1200

aggataagca gtgtgaacaa gctgtgtacc agacaatatt ggaagaggat gttgaagatc   1260

ctgtgtacca gtacattgtg tttgaggctg gacacgagcc aatccgtgat cccgaaacgg   1320

aagaaaacat ttatcaggtt cccaccagcc aaaagaagga aggtgtttat gatgtgccaa   1380

aaagtcaacc tgtaagtgct gtgacccaat tagaactttt tggggacatg tccacacccc   1440

ctgatataac ctctcccccc actcctgcaa ctccaggtga tgcctttatc ccatcttcat   1500

ctcagaccct tccagcgagt gcagatgtgt ttagttctgt acctttcggc actgctgctg   1560

taccctcagg ttacgttgca atgggcgctg tcctcccgtc cttctggggt cagcagcccc   1620

tcgtccaaca gcagatggtc atgggtgccc agccaccagt cgctcaggtg atgccggggg   1680

ctcagcccat cgcatggggc cagccgggtc tctttcctgc cactcagcag ccctggccaa   1740

ctgtggccgg gcagtttccg ccagccgcct tcatgcccac acaaactgtt atgcctttgc   1800

cagctgccat gttccaaggt cccctcaccc cccttgccac cgtcccaggc acgagtgact   1860

ccaccaggtc aagtccacag accgacaagc ccaggcagaa aatgggcaaa gaaacgttta   1920

aggatttcca gatggcccag cctccgcccg tgccctcccg caaacccgac cagccctccc   1980

tcacctgtac ctcagaggcc ttctccagtt acttcaacaa agtcggggtg gcacaggata   2040

cagacgactg tgatgacttt gacatctccc agttgaattt gacccctgtg acttctacca   2100

caccatcgac caactcacct ccaaccccag cccctagaca gagctctcca tccaaatcat   2160

ctgcatccca tgccagtgat cctaccacag atgacatctt tgaagagggc tttgaaagtc   2220

ccagcaaaag cgaagagcaa gaagctcctg atggatcaca ggcctcatcc aacagtgatc   2280

catttggtga gcccagtggg gagcccagtg gtgataatat aagtccacag gccggtagct   2340

agatagcgca ggtctgggag ccagagcctc tgtacgcgca gatcaacaga cctaagaaat   2400

agcatcgatg cgagctcgtg gtgggtgctc aagactggca tggacatcag catcacgaca   2460

ggctctcttg tattctttca cctcttccca caagaaattc atgattgccc aatggaactc   2520

gctcagaaga gggaactaag catttttggc aaccaatggc agatatctat ggcagcacac   2580


<210>  80
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Ser Thr Glu Thr Glu Leu Gln Val Ala Val Lys Thr Ser Ala Lys 
1               5                   10                  15


Lys Asp Ser Arg Lys Lys Gly Gln Asp Arg Ser Glu Ala Thr Leu Ile 
            20                  25                  30


Lys Arg Phe Lys Gly Glu Gly Val Arg Tyr Lys Ala Lys Leu Ile Gly 
        35                  40                  45


Ile Asp Glu Val Ser Ala Ala Arg Gly Asp Lys Leu Cys Gln Asp Ser 
    50                  55                  60


Met Met Lys Leu Lys Gly Val Val Ala Gly Ala Arg Ser Lys Gly Glu 
65                  70                  75                  80


His Lys Gln Lys Ile Phe Leu Thr Ile Ser Phe Gly Gly Ile Lys Ile 
                85                  90                  95


Phe Asp Glu Lys Thr Gly Ala Leu Gln His His His Ala Val His Glu 
            100                 105                 110


Ile Ser Tyr Ile Ala Lys Asp Ile Thr Asp His Arg Ala Phe Gly Tyr 
        115                 120                 125


Val Cys Gly Lys Glu Gly Asn His Arg Phe Val Ala Ile Lys Thr Ala 
    130                 135                 140


Gln Ala Ala Glu Pro Val Ile Leu Asp Leu Arg Asp Leu Phe Gln Leu 
145                 150                 155                 160


Ile Tyr Glu Leu Lys Gln Arg Glu Glu Leu Glu Lys Lys Ala Gln Lys 
                165                 170                 175


Asp Lys Gln Cys Glu Gln Ala Val Tyr Gln Thr Ile Leu Glu Glu Asp 
            180                 185                 190


Val Glu Asp Pro Val Tyr Gln Tyr Ile Val Phe Glu Ala Gly His Glu 
        195                 200                 205


Pro Ile Arg Asp Pro Glu Thr Glu Glu Asn Ile Tyr Gln Val Pro Thr 
    210                 215                 220


Ser Gln Lys Lys Glu Gly Val Tyr Asp Val Pro Lys Ser Gln Pro Val 
225                 230                 235                 240


Ser Ala Val Thr Gln Leu Glu Leu Phe Gly Asp Met Ser Thr Pro Pro 
                245                 250                 255


Asp Ile Thr Ser Pro Pro Thr Pro Ala Thr Pro Gly Asp Ala Phe Ile 
            260                 265                 270


Pro Ser Ser Ser Gln Thr Leu Pro Ala Ser Ala Asp Val Phe Ser Ser 
        275                 280                 285


Val Pro Phe Gly Thr Ala Ala Val Pro Ser Gly Tyr Val Ala Met Gly 
    290                 295                 300


Ala Val Leu Pro Ser Phe Trp Gly Gln Gln Pro Leu Val Gln Gln Gln 
305                 310                 315                 320


Met Val Met Gly Ala Gln Pro Pro Val Ala Gln Val Met Pro Gly Ala 
                325                 330                 335


Gln Pro Ile Ala Trp Gly Gln Pro Gly Leu Phe Pro Ala Thr Gln Gln 
            340                 345                 350


Pro Trp Pro Thr Val Ala Gly Gln Phe Pro Pro Ala Ala Phe Met Pro 
        355                 360                 365


Thr Gln Thr Val Met Pro Leu Pro Ala Ala Met Phe Gln Gly Pro Leu 
    370                 375                 380


Thr Pro Leu Ala Thr Val Pro Gly Thr Ser Asp Ser Thr Arg Ser Ser 
385                 390                 395                 400


Pro Gln Thr Asp Lys Pro Arg Gln Lys Met Gly Lys Glu Thr Phe Lys 
                405                 410                 415


Asp Phe Gln Met Ala Gln Pro Pro Pro Val Pro Ser Arg Lys Pro Asp 
            420                 425                 430


Gln Pro Ser Leu Thr Cys Thr Ser Glu Ala Phe Ser Ser Tyr Phe Asn 
        435                 440                 445


Lys Val Gly Val Ala Gln Asp Thr Asp Asp Cys Asp Asp Phe Asp Ile 
    450                 455                 460


Ser Gln Leu Asn Leu Thr Pro Val Thr Ser Thr Thr Pro Ser Thr Asn 
465                 470                 475                 480


Ser Pro Pro Thr Pro Ala Pro Arg Gln Ser Ser Pro Ser Lys Ser Ser 
                485                 490                 495


Ala Ser His Ala Ser Asp Pro Thr Thr Asp Asp Ile Phe Glu Glu Gly 
            500                 505                 510


Phe Glu Ser Pro Ser Lys Ser Glu Glu Gln Glu Ala Pro Asp Gly Ser 
        515                 520                 525


Gln Ala Ser Ser Asn Ser Asp Pro Phe Gly Glu Pro Ser Gly Glu Pro 
    530                 535                 540


Ser Gly Asp Asn Ile Ser Pro Gln Ala Gly Ser 
545                 550                 555


<210>  81
<211>  1579
<212>  DNA
<213>  Homo sapiens

<400>  81
atgtgggacc atggattagg tgagaagaca ggaagtgaga tccaaacaga gatcaacagc     60

gacttgctcc tttctgcccg tggatgccgc cgaagaagca tcgttaaagt ctctcttctc    120

cctgccatcc tgtctaagtc agagtctcct aaagagcccg aacagcttag gaagctcttc    180

actggagggc tgagctttga caccactgat gagaacctga gaagccattt tgagcaatag    240

ggaacgctca cggactgtgt ggtcctgaga gatccaaaca ccaagtgctc cgggggcttt    300

gggtttgtca catatgccac tgtggaggag gtggatgcag ccacaaatgc aaggccacac    360

aaggtgggtg gaagagttgt ggaaacagag agctgtctca agagaagatt cccaaagacc    420

aggtgcccac ttaactgtga aaaaggtatt tgttggtggt tttaaagaag acactgaaga    480

acatcaccta agagattatt tttaacagtt ggaaaaatgg aagtgattga aatcatgact    540

gactgaggca gtggcaaaga aaaaggggct ttgcctttgt aacctttgac aaccatgatt    600

ccgtggataa gactgtcatt cagaaatact atactgtgaa tggccacaac tgtgaagtta    660

ggaaagccct gtcaaagcaa gagatggcta gtgtttcatc cagccaaaga ggtgaagtgg    720

ttctggaaac tttggtggtg gtcgtggagg tggtttcagt gggaatgaca actttggttg    780

tggaggaaac tttagtggtc atggtggctt tggtggcagc tgtgatgtca gtggatatgg    840

tggcagtggg gatggttata atgggtttgg caattatggt ggttatggag gaagtggccc    900

tggttactct ggaggaagca gaggctatgg aagtggtgga cagggttatg gaaaccaggg    960

cagtggctat ggcgggagtg gcagctatga cagctataac aatagaggtg gaggtagctt   1020

tggcagtggc agtggaagca gttttggagg tggtggaagc tacagtgatt tgggcaatta   1080

aaacaatcag ttttcaaatt ttggacccat gaagggggga gattttggag gcagaagctc   1140

tggcccctat ggcggtggag gccaatactt tgccaaactg tgaaaccaag gtggctatgg   1200

cggttccagt agcagcagta gctgtggcag tggcagaaga ttttaattag gaaacaaagc   1260

ttagcaggag agaagagcca gagaagtgac agggaagcta taggttacaa cagatttgtg   1320

aactcagcca aacacagtgg tggcagggcc tagctgctgc aaagaagaca tgttttagac   1380

aaatactcat gtatatgggc aaaaaacttg aggactatat ttgtgactaa ttgtataaca   1440

ggttatttta gttgctgttc tgtggaaagt gtaaagcatt ccaacaaagg gttttaatgt   1500

agattttttt ttgcacccat gctgttgatt gctaaatgta atagtctgat cgtgatgctg   1560

aataaatgcc ttaaaaaaa                                                1579


<210>  82
<211>  845
<212>  DNA
<213>  Homo sapiens

<400>  82
atgtgcatgt tgctgccaga gagtgatctg ggggacccag agaagcctgc ctcttttctg     60

gctggaacca tagaaggtgt tgaagagaag aaaaagaagg ttcctgctgt gccagaaacc    120

cttaagaaaa agcgaaagaa tttcgcagag ctgaagatca agcacctaag aaagaagttt    180

gtccaaaaga tgctttgaaa ggcaaggagg aagcttatct gtgaaaaagc aaagcactat    240

cacaaggaat ataggcagat gtacagaact gaaattcgaa tggtgaggaa ggcaagaaaa    300

gctggcaact tctatgtacc tgcagaacac agatcggtat ttgtcatcag gatcaggggt    360

atcaatggtg tggccaaaag gtccgaaagg tgttgcggct tcttcacctt cgtcaaatct    420

tcagtggaac ttttgtgaag cttaacaagg cttcaattaa catgctgagg attgtagatc    480

catatattgt atgggggtac ccaaatctga agtcagtaaa tgaactaatc tacaagtgtg    540

gttatggcaa aatcaataag aaaataattg ctttgacaga caacgctttg attgctccat    600

ctcttggtaa atatggcatc atctgcatgg aggatatgat taatgagatc tatactgttg    660

gaaaacactt caaagaagca aataacttcc tgtggccctt tgaattatct tctccacgag    720

gcggaatgaa gaaaaagacc acccattttg tagaaggtgg agatgctggc aacagacagg    780

accagatcaa caggtttttt agaagaatga actaaggtgt ctaccatgat tatttttcta    840

agctg                                                                845


<210>  83
<211>  652
<212>  DNA
<213>  Homo sapiens

<400>  83
atgagcagca aagtctcttg cgacaccgtg tacgaggtga tgcaggaagt cctgcaaggg     60

aaccagcaca agggccccaa gtctggagac agtggagttg cagattagtt tgaggaactg    120

tgactcccag aaggacaagc acctctcgga caccgtcagg cttaagtcca ctccccaccc    180

caagttctcc gtgtgtgtcc cggggtacca gcaacactgt gacgaggcca aggtcatgga    240

tatcccccac atggacatcg aggcgctgaa aaaactcaac aaaaataaga aactggtcaa    300

gaagctagcc aagaagtatg atgcattttt ggcctcagag cctctgatca agtggatccc    360

acaaatcctg ggcccaggcc taaataaggc aggaaagttc ccttccctgc tcacacacaa    420

tgaaaacatg gcggccaaag cggatgaggt gaagtccacc ttcaagttcc aaatgaagaa    480

ggtgttatgt ctggctgtgg ctgttggcca cgtgaagatg acagaagatg agcttgtgta    540

gaacattcac ctggctgtca aattcttgct gtcattgctc aagaaaaact ggcagaatgt    600

cctggcctta tatatcaaga gcaccatggg caagcctcag cacctatatt aa            652


<210>  84
<211>  1566
<212>  DNA
<213>  Homo sapiens

<400>  84
ccttgtcctg cccagatctt gtcccttcta gtactggcct tccccattcc tgggggcccc     60

cgcccctccg acccccgccg accggcgctg gactacaact cccggcgtgc cgcgcgcgtc    120

cggccggctg caccggggct ttgcgcgtgg cggccgccga gctccgcgcg gggcaaacct    180

cccggcgcgg ccatgcgggg agttgctgaa gtaaaggaac cctgcagcct tcccatgcta    240

tctgttgaca tggaaaacaa ggaaaatggc tctgtcggtg taaaaaattc catggaaaat    300

gggagaccac ctgatcctgc agactgggcc gtgatggatg tcgtcaatta tttccgaacc    360

gtgggatttg aggagcaagc tagtgctttt caggaacagg aaattgatgg aaaatccctg    420

ctattgatga caagaaatga tgtgttgaca ggacttcagt taaaattggg gcctgctctg    480

aaaatctacg aatatcatgt aaaacctctg cagacaaagc atttaaagaa caactcttca    540

tagtacagtc aaattggggt cttcgacctc aaaaaaatac ataatgacat aatttagttt    600

catgtaatga aactttgtaa acagaataca tacatgtgta tatgtaaaga atttcaatca    660

aatgaaacgt tatcctattg gatagactag gcaattcatc agctcacctg aaatcagcca    720

ggaggagcaa ggacaagatg cgcacagggt ggttttcctc atggattttg tcaaatagat    780

gatctttgac acgattagac actcctcccc acaaaggctt tgaaatcata aggattttcc    840

tcatctcttt atagctttcc caaaatcttt taaaaaagaa tttaattaaa tgacagtctt    900

ttggttacag acttaggatg agtaaaaaca agaaaatttg gggaggggga gaaagaagaa    960

agggattgct gtctcccttg aattcctctg ttccttagag cttgtgttac ttggacggaa   1020

ttgccaacac ccttttttat agagggttct ccacttgacc ttattaaggt tttattggga   1080

tatgctgcag tgtttgaaat gaacatgcat catggcccct tcaggagcag aatcatagct   1140

ctgaaaagag aagctccgtt gtgtactgag gatatccatc catattcagc tagctttcaa   1200

atggggtaat gatattttct gcatagattt tcttttaaat tggttctttg tttctgaaga   1260

aagaattttt tttaacttca tggttttatt tataataatt tgtttctgaa gaaatttgcc   1320

gagagttaca ggtcaaaaag ccttgttact agtacagaat atttttatat atattccttc   1380

atgatggtgt aatttttttt aattgtccta tgctttgttc ggttcctggg ttaagtactt   1440

gtttttaaga gcttggaaaa agtgggcttg ctacatctct gttcaaagag acatttgttc   1500

aatctctgtg tgtcaacgcc ttgttgaatt ggtgctttgt ggttgcaata aagcattgct   1560

tcagtt                                                              1566


<210>  85
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Arg Gly Val Ala Glu Val Lys Glu Pro Cys Ser Leu Pro Met Leu 
1               5                   10                  15


Ser Val Asp Met Glu Asn Lys Glu Asn Gly Ser Val Gly Val Lys Asn 
            20                  25                  30


Ser Met Glu Asn Gly Arg Pro Pro Asp Pro Ala Asp Trp Ala Val Met 
        35                  40                  45


Asp Val Val Asn Tyr Phe Arg Thr Val Gly Phe Glu Glu Gln Ala Ser 
    50                  55                  60


Ala Phe Gln Glu Gln Glu Ile Asp Gly Lys Ser Leu Leu Leu Met Thr 
65                  70                  75                  80


Arg Asn Asp Val Leu Thr Gly Leu Gln Leu Lys Leu Gly Pro Ala Leu 
                85                  90                  95


Lys Ile Tyr Glu Tyr His Val Lys Pro Leu Gln Thr Lys His Leu Lys 
            100                 105                 110


Asn Asn Ser Ser 
        115


<210>  86
<211>  1279
<212>  DNA
<213>  Homo sapiens

<400>  86
atggggaaag tgtcctgctg tggcatgaaa taaatgaaac agaaaatgat ggcaagactg     60

ctaagaacat cctttgcttt gctcttcctt ggcctctttg gggtgctggg ggcagcaaca    120

atttcatgca gaaatgaaga agggaaagct gtggactggt ttacttttta taagttacct    180

aaaagacaaa acaaggaaag tggagagact gggttagagt acctgtacct agactctaca    240

actagaagct ggaggaagag tgagcaacta atgaatgaca ccaagagtgt tttgggaagg    300

acattacaac agctatatga agcatatgcc tctaagagta acaacacagc ctatctaata    360

tacaatgatg gagtccctaa acctgtgaat tacagcagaa agtatggaca caccaaaggt    420

ttactgctgt ggaacagagt tcaagggttc tggctgattc attccatccc tcagtttcct    480

ccaattccgg aagaaggcta tgattatcca cccacaggga gacgaaatgg acaaagtggc    540

atctgcataa ctttcaagta caaccagtat gaggcaatag attctcagct cttggtctgc    600

aaccccaacg tctatagctg ctccatccca gccacctttc accaggagct cattcacatg    660

ccccagctgt gcaccagggc cagctcatca gagattcctg gcaggctcct caccacactt    720

cagtcggccc agggacaaaa attcctccat tttgcaaagt cggattcttt tcttgacgac    780

atctttgcag cctggatggc tcaacggctg aagacacact tgttaacaga aacctggcag    840

cgaaaaagac aagagcttcc ttcaaactgc tcccttcctt accatgtcta caatataaaa    900

gcaattaaat tatcacgaca ctcttatttc agttcttatc aagatcatgc caagtggtgt    960

atttcccaaa agggcaccaa aaatcgctgg acatgtattg gagacctaaa tcggagtcca   1020

caccaagcct tcagaagtgg aggattcatt tgtacccaga attggcaaat ttaccaagca   1080

tttcaaggat tagtattata ctatgaaagc tgtaagtaaa cttggtgaaa ggacacaggt   1140

actatcattg aaaaccttga caatgggtct tcttccatta caccttcttt atattttaaa   1200

ggcctgtgaa tatacttata acctgcatat cacaaaataa aacatttttc tctcatgtta   1260

aaaaaaaaaa aaaaaaaaa                                                1279


<210>  87
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Met Ala Arg Leu Leu Arg Thr Ser Phe Ala Leu Leu Phe Leu Gly 
1               5                   10                  15


Leu Phe Gly Val Leu Gly Ala Ala Thr Ile Ser Cys Arg Asn Glu Glu 
            20                  25                  30


Gly Lys Ala Val Asp Trp Phe Thr Phe Tyr Lys Leu Pro Lys Arg Gln 
        35                  40                  45


Asn Lys Glu Ser Gly Glu Thr Gly Leu Glu Tyr Leu Tyr Leu Asp Ser 
    50                  55                  60


Thr Thr Arg Ser Trp Arg Lys Ser Glu Gln Leu Met Asn Asp Thr Lys 
65                  70                  75                  80


Ser Val Leu Gly Arg Thr Leu Gln Gln Leu Tyr Glu Ala Tyr Ala Ser 
                85                  90                  95


Lys Ser Asn Asn Thr Ala Tyr Leu Ile Tyr Asn Asp Gly Val Pro Lys 
            100                 105                 110


Pro Val Asn Tyr Ser Arg Lys Tyr Gly His Thr Lys Gly Leu Leu Leu 
        115                 120                 125


Trp Asn Arg Val Gln Gly Phe Trp Leu Ile His Ser Ile Pro Gln Phe 
    130                 135                 140


Pro Pro Ile Pro Glu Glu Gly Tyr Asp Tyr Pro Pro Thr Gly Arg Arg 
145                 150                 155                 160


Asn Gly Gln Ser Gly Ile Cys Ile Thr Phe Lys Tyr Asn Gln Tyr Glu 
                165                 170                 175


Ala Ile Asp Ser Gln Leu Leu Val Cys Asn Pro Asn Val Tyr Ser Cys 
            180                 185                 190


Ser Ile Pro Ala Thr Phe His Gln Glu Leu Ile His Met Pro Gln Leu 
        195                 200                 205


Cys Thr Arg Ala Ser Ser Ser Glu Ile Pro Gly Arg Leu Leu Thr Thr 
    210                 215                 220


Leu Gln Ser Ala Gln Gly Gln Lys Phe Leu His Phe Ala Lys Ser Asp 
225                 230                 235                 240


Ser Phe Leu Asp Asp Ile Phe Ala Ala Trp Met Ala Gln Arg Leu Lys 
                245                 250                 255


Thr His Leu Leu Thr Glu Thr Trp Gln Arg Lys Arg Gln Glu Leu Pro 
            260                 265                 270


Ser Asn Cys Ser Leu Pro Tyr His Val Tyr Asn Ile Lys Ala Ile Lys 
        275                 280                 285


Leu Ser Arg His Ser Tyr Phe Ser Ser Tyr Gln Asp His Ala Lys Trp 
    290                 295                 300


Cys Ile Ser Gln Lys Gly Thr Lys Asn Arg Trp Thr Cys Ile Gly Asp 
305                 310                 315                 320


Leu Asn Arg Ser Pro His Gln Ala Phe Arg Ser Gly Gly Phe Ile Cys 
                325                 330                 335


Thr Gln Asn Trp Gln Ile Tyr Gln Ala Phe Gln Gly Leu Val Leu Tyr 
            340                 345                 350


Tyr Glu Ser Cys Lys 
        355


<210>  88
<211>  1029
<212>  DNA
<213>  Homo sapiens

<400>  88
attgcaggct gggtagctgg tagaaatgtt gtgggcgttt gtaagtggaa gatttacgcc     60

attataaccc taatatattc ctgcagagta acaacacagc ctatctaata tacaatgatg    120

gagtccctaa acctgtgaat tacagcagaa agtatggaca caccaaaggt ttactgctgt    180

ggaacagagt tcaagggttc tggctgattc attccatccc tcagtttcct ccaattccgg    240

aagaaggcta tgattatcca cccacaggga gacgaaatgg acaaagtggc atctgcataa    300

ctttcaagta caaccagtat gaggcaatag attctcagct cttggtctgc aaccccaacg    360

tctatagctg ctccatccca gccacctttc accaggagct cattcacatg ccccagctgt    420

gcaccagggc cagctcatca gagattcctg gcaggctcct caccacactt cagtcggccc    480

agggacaaaa attcctccat tttgcaaagt cggattcttt tcttgacgac atctttgcag    540

cctggatggc tcaacggctg aagacacact tgttaacaga aacctggcag cgaaaaagac    600

aagagcttcc ttcaaactgc tcccttcctt accatgtcta caatataaaa gcaattaaat    660

tatcacgaca ctcttatttc agttcttatc aagatcatgc caagtggtgt atttcccaaa    720

agggcaccaa aaatcgctgg acatgtattg gagacctaaa tcggagtcca caccaagcct    780

tcagaagtgg aggattcatt tgtacccaga attggcaaat ttaccaagca tttcaaggat    840

tagtattata ctatgaaagc tgtaagtaaa cttggtgaaa ggacacaggt actatcattg    900

aaaaccttga caatgggtct tcttccatta caccttcttt atattttaaa ggcctgtgaa    960

tatacttata acctgcatat cacaaaataa aacatttttc tctcatgtta aaaaaaaaaa   1020

aaaaaaaaa                                                           1029


<210>  89
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Pro Gln Leu Cys Thr Arg Ala Ser Ser Ser Glu Ile Pro Gly Arg 
1               5                   10                  15


Leu Leu Thr Thr Leu Gln Ser Ala Gln Gly Gln Lys Phe Leu His Phe 
            20                  25                  30


Ala Lys Ser Asp Ser Phe Leu Asp Asp Ile Phe Ala Ala Trp Met Ala 
        35                  40                  45


Gln Arg Leu Lys Thr His Leu Leu Thr Glu Thr Trp Gln Arg Lys Arg 
    50                  55                  60


Gln Glu Leu Pro Ser Asn Cys Ser Leu Pro Tyr His Val Tyr Asn Ile 
65                  70                  75                  80


Lys Ala Ile Lys Leu Ser Arg His Ser Tyr Phe Ser Ser Tyr Gln Asp 
                85                  90                  95


His Ala Lys Trp Cys Ile Ser Gln Lys Gly Thr Lys Asn Arg Trp Thr 
            100                 105                 110


Cys Ile Gly Asp Leu Asn Arg Ser Pro His Gln Ala Phe Arg Ser Gly 
        115                 120                 125


Gly Phe Ile Cys Thr Gln Asn Trp Gln Ile Tyr Gln Ala Phe Gln Gly 
    130                 135                 140


Leu Val Leu Tyr Tyr Glu Ser Cys Lys 
145                 150


<210>  90
<211>  1975
<212>  DNA
<213>  Homo sapiens

<400>  90
agaaggctat ttccgtttcc gtacggaagc aaaggagcca agaccatggc gaaagccggg     60

gataagagca gcagcagcgg gaagaaaagt ctaaaacgga aagccgctgc cgaagaactt    120

caggaggctg caggcgctgg ggatggggcg acggaaaacg gggtccaacc cccgaaagcg    180

gctgcctttc cgccaggctt tagcatttcg gagattaaaa acaaacagcg gcgacactta    240

atgttcacgc ggtggaaaca gcagcagcgg aaggaaaagt tggcagctaa gaaaaaactt    300

aaaaaagaaa gagaggctct tggcgataag gctccaccaa agcctgtacc caagaccatt    360

gacaaccagc gagtgtatga tgaaaccaca gtagacccta atgatgaaga ggtcgcttat    420

gatgaagcta cagatgaatt tgcttcttac ttcaacaaac agacttctcc caagattctc    480

atcacaacat cagatagacc tcatgggaga acagtacgac tctgtgaaca gctctccaca    540

gttataccaa actcacatgt ttattacaga agaggactgg ctctgaaaaa aattattcca    600

cagtgcatcg caagagattt cacagacctg attgttatta atgaagatcg taaaacccca    660

aatggactta ttttgagtca cttgccaaat ggcccaactg ctcattttaa aatgagcagt    720

gttcgtcttc gtaaagaaat taagagaaga ggcaaggacc ccacagaaca catacctgaa    780

ataattctga ataattttac aacacggctg ggtcattcaa ttggacgtat gtttgcatct    840

ctctttcctc ataatcctca atttatcgga aggcaggttg ccacattcca caatcaacgg    900

gattacatat tcttcagatt tcacagatac atattcagga gtgaaaagaa agtgggaatt    960

caggaacttg gaccacgttt taccttaaaa ttaaggtctc ttcagaaagg aacctttgat   1020

tctaaatatg gagagtatga atgggtccat aagccccggg aaatggatac aagtagaaga   1080

aaattccatt tataaagtac tgagagaatg atattggatt ttgctgaaca ggcctatctt   1140

gaactttggt aaattatttt tgacagaata ctcttttcaa aatggcattt gctgatttca   1200

taaacctttc acgtctggac gaattaccaa atgccatgaa ttgccactgt gtgtttatgt   1260

agaaaataca aataaaagtt attttgatgg cttaggtttc cttaaactta gttctcttgt   1320

ttttgggtaa ctgtgaataa ttaagttgga atcaagattc agattaactt tcctatttgc   1380

atagaacaca tgagaggaat aaaatggttg gtaaatattg gctaaccctt gatttttata   1440

ccagattaac cttggattcc cagtgtctgg cacagtttta atagcttaaa tggaggccag   1500

gtttctggat gttttaacat tctcttaagc cttcagaagg gtaaaaaatt taaagcaaaa   1560

tgatctacca gggtttaaag caaagttgca aattactgaa gctaatcttt gcttcctgat   1620

tttgaggttt ttggtttttt gtgcccacgt tgtggggagc tcttttttac ctcattacat   1680

ggtgctgtag tactccattc aggcactgaa acaaagttaa ccctataagt aactcatgga   1740

tggaaacccg tagaacttaa cagcctcctc ctgaccttaa aagaataaag gttcacagtt   1800

tacctttaat tccctagcag tcttgccaga tgtatggcat aaagtcatgt gagaagagta   1860

ggtggaaaaa actgtacaaa cttaacccct tcaggtgttc agaacagatt aatataccat   1920

gtatttaata ccaataataa tgcaaaataa aagtttcata ctaagtttta ttgta        1975


<210>  91
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Ala Lys Ala Gly Asp Lys Ser Ser Ser Ser Gly Lys Lys Ser Leu 
1               5                   10                  15


Lys Arg Lys Ala Ala Ala Glu Glu Leu Gln Glu Ala Ala Gly Ala Gly 
            20                  25                  30


Asp Gly Ala Thr Glu Asn Gly Val Gln Pro Pro Lys Ala Ala Ala Phe 
        35                  40                  45


Pro Pro Gly Phe Ser Ile Ser Glu Ile Lys Asn Lys Gln Arg Arg His 
    50                  55                  60


Leu Met Phe Thr Arg Trp Lys Gln Gln Gln Arg Lys Glu Lys Leu Ala 
65                  70                  75                  80


Ala Lys Lys Lys Leu Lys Lys Glu Arg Glu Ala Leu Gly Asp Lys Ala 
                85                  90                  95


Pro Pro Lys Pro Val Pro Lys Thr Ile Asp Asn Gln Arg Val Tyr Asp 
            100                 105                 110


Glu Thr Thr Val Asp Pro Asn Asp Glu Glu Val Ala Tyr Asp Glu Ala 
        115                 120                 125


Thr Asp Glu Phe Ala Ser Tyr Phe Asn Lys Gln Thr Ser Pro Lys Ile 
    130                 135                 140


Leu Ile Thr Thr Ser Asp Arg Pro His Gly Arg Thr Val Arg Leu Cys 
145                 150                 155                 160


Glu Gln Leu Ser Thr Val Ile Pro Asn Ser His Val Tyr Tyr Arg Arg 
                165                 170                 175


Gly Leu Ala Leu Lys Lys Ile Ile Pro Gln Cys Ile Ala Arg Asp Phe 
            180                 185                 190


Thr Asp Leu Ile Val Ile Asn Glu Asp Arg Lys Thr Pro Asn Gly Leu 
        195                 200                 205


Ile Leu Ser His Leu Pro Asn Gly Pro Thr Ala His Phe Lys Met Ser 
    210                 215                 220


Ser Val Arg Leu Arg Lys Glu Ile Lys Arg Arg Gly Lys Asp Pro Thr 
225                 230                 235                 240


Glu His Ile Pro Glu Ile Ile Leu Asn Asn Phe Thr Thr Arg Leu Gly 
                245                 250                 255


His Ser Ile Gly Arg Met Phe Ala Ser Leu Phe Pro His Asn Pro Gln 
            260                 265                 270


Phe Ile Gly Arg Gln Val Ala Thr Phe His Asn Gln Arg Asp Tyr Ile 
        275                 280                 285


Phe Phe Arg Phe His Arg Tyr Ile Phe Arg Ser Glu Lys Lys Val Gly 
    290                 295                 300


Ile Gln Glu Leu Gly Pro Arg Phe Thr Leu Lys Leu Arg Ser Leu Gln 
305                 310                 315                 320


Lys Gly Thr Phe Asp Ser Lys Tyr Gly Glu Tyr Glu Trp Val His Lys 
                325                 330                 335


Pro Arg Glu Met Asp Thr Ser Arg Arg Lys Phe His Leu 
            340                 345


<210>  92
<211>  698
<212>  DNA
<213>  Homo sapiens

<400>  92
cacaaactgg gaggaaaact gagacctcct ggtacccgcc gccgggcctt ttagaaactc     60

ccacaagctc tgccttccct ccctggtcct cttcagaccc cctcttagtt cttcgcggct    120

aacggctcgc gctcggggcc gggtgtggag ctggaacaga gggctggcaa ggcgcgcatc    180

ggaccgaggg tggagccgct gagcacagaa ccggaaactt agagacaaag ttcggagccc    240

cgcccccgcc gcgcgccgct gagttgtctg gccccgccga cccacggccc acgacccacc    300

gacccacgaa tcggcccggc cgtcgcgtgc accatgtctg gctcctccag cgtcgccgct    360

atgaagaaag tggttcaaca gctccggctg gaggccggac tcaaccgcgt aaaagtttcc    420

caggcagctg cagacttgaa acagttctgt ctgcagaatg ctcaacatga ccctctgctg    480

actggagtat cttcaagtac aaatcccttc agaccccaga aagtctgttc ctttttgtag    540

taaaatgaat ctttcaaagg tttcccaaac cactccttat gatccagtga tattcaagag    600

agctacattt gaagcctgta caaaagctta tccctgtaac acatgtgcca taatatacaa    660

acttctactt tcgtcagtcc ttaacatcta cctctctg                            698


<210>  93
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Ser Gly Ser Ser Ser Val Ala Ala Met Lys Lys Val Val Gln Gln 
1               5                   10                  15


Leu Arg Leu Glu Ala Gly Leu Asn Arg Val Lys Val Ser Gln Ala Ala 
            20                  25                  30


Ala Asp Leu Lys Gln Phe Cys Leu Gln Asn Ala Gln His Asp Pro Leu 
        35                  40                  45


Leu Thr Gly Val Ser Ser Ser Thr Asn Pro Phe Arg Pro Gln Lys Val 
    50                  55                  60


Cys Ser Phe Leu 
65


<210>  94
<211>  1618
<212>  DNA
<213>  Homo sapiens

<400>  94
atgtcccggc cgcagcttcg acgctggcgc ctcgtctcta gcccgccgag cggcgtcccg     60

ggtctagcgc tgctggcgct gctggcgctg ctggcgctgc ggctcgcggc cgggaccgac    120

tgcccatgcc cggagcctga gctctgccgc ccgattcgcc accatccaga tttcgaggtc    180

tttgtgtttg atgttggaca gaaaacttgg aaatcttatg attggtcaca gattacaact    240

gtggcaacat ttggaaaata tgactcagaa cttatgtgct acgctcattc aaaaggagcc    300

agagtagtac ttaaaggaga tgtatcctta aaggatatca ttgatcctgc tttcagagca    360

tcctggatag ctcaaaaact taatttggcc aaaacacaat atatggatgg aattaatata    420

gatatagagc aagaagttaa ttgtttatca cctgaatatg atgcattaac tgctttagtc    480

aaagaaacta cagactcttt ccatcgtgaa attgagggat cacaggtaac ctttgatgta    540

gcttggtctc caaagaacat agacagaaga tgctataatt atactggaat cgcagatgct    600

tgtgacttcc tctttgtgat gtcttatgat gaacaaagtc agatctggtc agaatgtatt    660

gcagcagcca atgctcccta taatcagaca ttaactggat ataatgacta catcaagatg    720

agcattaatc ctaagaaact tgtaatgggt gttccttggt atggttatga ttatacctgc    780

ctgaatctgt ctgaggatca tgtttgtacc attgcaaaag tccctttccg gggggctcct    840

tgtagtgacg ctgcaggacg tcaggtgccc tacaaaacga tcatgaagca aataaatagt    900

tctatttctg gaaacctatg ggataaagat cagcgggctc cttattataa ctataaagat    960

cctgctggcc actttcatca agtatggtat gataaccctc agagtatttc tttaaaggca   1020

acatatatac aaaactatcg cttacggggc attggcatgt ggaatgcaaa ctgtcttgac   1080

tactctggag atgctgtagc caaacagcaa actgaagaaa tgtgggaagt cttaaagcca   1140

aagctgttac agagatgaac atcttttgtc aaaccattaa gagttagaaa gatgatctgt   1200

atcaacagat ctagtttctt gcatttttat tatgttgcta tatacttttg ttatccgtat   1260

actaaaaaaa aagaataaat aaatgttttg attgtttgaa tttgaaaaat acacacgaat   1320

gtcctcagta tccaggaaca taaaggcaag aagcaagtca acttacctat taaatattcc   1380

tctattagat gtttcaacac tataatttaa ttgggaaaaa ttgctttcag aattttatta   1440

tgccatattt cccttcatta tagtaaaata tatgctcacg aatcaatgct gatttttaaa   1500

atatgtataa tctgaagtgg aaattgtttg cttagagttt ttaaaaacct agtctttgaa   1560

aagcagtttg tgctatactt ttcccccaac cctccaataa atcttaaatt taaaacct     1618


<210>  95
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Ser Arg Pro Gln Leu Arg Arg Trp Arg Leu Val Ser Ser Pro Pro 
1               5                   10                  15


Ser Gly Val Pro Gly Leu Ala Leu Leu Ala Leu Leu Ala Leu Leu Ala 
            20                  25                  30


Leu Arg Leu Ala Ala Gly Thr Asp Cys Pro Cys Pro Glu Pro Glu Leu 
        35                  40                  45


Cys Arg Pro Ile Arg His His Pro Asp Phe Glu Val Phe Val Phe Asp 
    50                  55                  60


Val Gly Gln Lys Thr Trp Lys Ser Tyr Asp Trp Ser Gln Ile Thr Thr 
65                  70                  75                  80


Val Ala Thr Phe Gly Lys Tyr Asp Ser Glu Leu Met Cys Tyr Ala His 
                85                  90                  95


Ser Lys Gly Ala Arg Val Val Leu Lys Gly Asp Val Ser Leu Lys Asp 
            100                 105                 110


Ile Ile Asp Pro Ala Phe Arg Ala Ser Trp Ile Ala Gln Lys Leu Asn 
        115                 120                 125


Leu Ala Lys Thr Gln Tyr Met Asp Gly Ile Asn Ile Asp Ile Glu Gln 
    130                 135                 140


Glu Val Asn Cys Leu Ser Pro Glu Tyr Asp Ala Leu Thr Ala Leu Val 
145                 150                 155                 160


Lys Glu Thr Thr Asp Ser Phe His Arg Glu Ile Glu Gly Ser Gln Val 
                165                 170                 175


Thr Phe Asp Val Ala Trp Ser Pro Lys Asn Ile Asp Arg Arg Cys Tyr 
            180                 185                 190


Asn Tyr Thr Gly Ile Ala Asp Ala Cys Asp Phe Leu Phe Val Met Ser 
        195                 200                 205


Tyr Asp Glu Gln Ser Gln Ile Trp Ser Glu Cys Ile Ala Ala Ala Asn 
    210                 215                 220


Ala Pro Tyr Asn Gln Thr Leu Thr Gly Tyr Asn Asp Tyr Ile Lys Met 
225                 230                 235                 240


Ser Ile Asn Pro Lys Lys Leu Val Met Gly Val Pro Trp Tyr Gly Tyr 
                245                 250                 255


Asp Tyr Thr Cys Leu Asn Leu Ser Glu Asp His Val Cys Thr Ile Ala 
            260                 265                 270


Lys Val Pro Phe Arg Gly Ala Pro Cys Ser Asp Ala Ala Gly Arg Gln 
        275                 280                 285


Val Pro Tyr Lys Thr Ile Met Lys Gln Ile Asn Ser Ser Ile Ser Gly 
    290                 295                 300


Asn Leu Trp Asp Lys Asp Gln Arg Ala Pro Tyr Tyr Asn Tyr Lys Asp 
305                 310                 315                 320


Pro Ala Gly His Phe His Gln Val Trp Tyr Asp Asn Pro Gln Ser Ile 
                325                 330                 335


Ser Leu Lys Ala Thr Tyr Ile Gln Asn Tyr Arg Leu Arg Gly Ile Gly 
            340                 345                 350


Met Trp Asn Ala Asn Cys Leu Asp Tyr Ser Gly Asp Ala Val Ala Lys 
        355                 360                 365


Gln Gln Thr Glu Glu Met Trp Glu Val Leu Lys Pro Lys Leu Leu Gln 
    370                 375                 380


Arg 
385


<210>  96
<211>  1735
<212>  DNA
<213>  Homo sapiens

<400>  96
caaaatccca ggcagcatgg acctcagtct tctctgggta cttctgcccc tagtcaccat     60

ggcctggggc cagtatggcg attatggata cccataccag cagtatcatg actacagcga    120

tgatgggtgg gtgaatttga accggcaagg cttcagctac cagtgtcccc aggggcaggt    180

gatagtggcc gtgaggagca tcttcagcaa gaaggaaggt tctgacagac aatggaacta    240

cgcctgcatg cccacgccac agagcctcgg ggaacccacg gagtgctggt gggaggagat    300

caacagggct ggcatggaat ggtaccagac gtgctccaac aatgggctgg tggcaggatt    360

ccagagccgc tacttcgagt cagtgctgga tcgggagtgg cagttttact gttgtcgcta    420

cagcaagagg tgcccatatt cctgctggct aacaacagaa tatccaggtc actatggtga    480

ggaaatggac atgatttcct acaattatga ttactatatc cgaggagcaa caaccacttt    540

ctctgcagtg gaaagggatc gccagtggaa gttcataatg tgccggatga ctgaatacga    600

ctgtgaattt gcaaatgttt agatttgcca cataccaaat ctgggtgaaa ggaaaggggc    660

cggggacagg agggtgtcca catatgttaa catcagttgg atctcctata gaagtttctg    720

ctgctctctt tccttctccc tgagctggta actgcaatgc caacttcctg ggcctttctg    780

actagtatca cacttctaat aaaatccaca attaaaccat gtttctcact tttcacatgt    840

ttcatagcaa ctgctttata tgactgatga tggcttcctt gcacaccaca tatacagtgc    900

gcatgcttac agccgggctt ctggagcacc agctgcagcc tggctactgc tttttactgc    960

agaatgaact gcaagttcag catagtggag gggagaggca gaactggagg agaggtgcag   1020

tgaaggttct ctacagctaa gcctgtttga atgatacgta ggttccccac caaaagcagg   1080

ctttctgccc tgagggacat cttcccactc ccctgctcca catgagccat gcatgcttag   1140

caatccaagt gcagagctct ttgctccagg agtgaggaga ctgggaggtg aaatggggaa   1200

atggaagggt ttggaggcag agctgaaaac agggttggaa ggatttcctg aattagaaga   1260

caaacgttag catacccagt aaggaaaatg agtgcagggg ccaggggaac ccgtgaggat   1320

cactctcaaa tgagattaaa aacaaggaag cagagaatgg tcagagaatg ggattcagat   1380

tgggaacttg tggggatgag agtgaccagg ttgaactggg aagtggaaaa aggagtttga   1440

gtcactggca cctagaagcc tgcccacgat tcctaggaag gctggcagac accctggaac   1500

cctggggagc tactggcaaa ctctcctgga ttgggcctga tttttttggt gggaaaggct   1560

gccctgggga tcaactttcc ttctgtgtgt ggctcaggag ttcttctgca gagatggcgc   1620

tatctttcct cctcctgtga tgtcctgctc ccaaccattt gtactcttca ttacaaaaga   1680

aataaaaata ttaacgttca ctaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa        1735


<210>  97
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Asp Leu Ser Leu Leu Trp Val Leu Leu Pro Leu Val Thr Met Ala 
1               5                   10                  15


Trp Gly Gln Tyr Gly Asp Tyr Gly Tyr Pro Tyr Gln Gln Tyr His Asp 
            20                  25                  30


Tyr Ser Asp Asp Gly Trp Val Asn Leu Asn Arg Gln Gly Phe Ser Tyr 
        35                  40                  45


Gln Cys Pro Gln Gly Gln Val Ile Val Ala Val Arg Ser Ile Phe Ser 
    50                  55                  60


Lys Lys Glu Gly Ser Asp Arg Gln Trp Asn Tyr Ala Cys Met Pro Thr 
65                  70                  75                  80


Pro Gln Ser Leu Gly Glu Pro Thr Glu Cys Trp Trp Glu Glu Ile Asn 
                85                  90                  95


Arg Ala Gly Met Glu Trp Tyr Gln Thr Cys Ser Asn Asn Gly Leu Val 
            100                 105                 110


Ala Gly Phe Gln Ser Arg Tyr Phe Glu Ser Val Leu Asp Arg Glu Trp 
        115                 120                 125


Gln Phe Tyr Cys Cys Arg Tyr Ser Lys Arg Cys Pro Tyr Ser Cys Trp 
    130                 135                 140


Leu Thr Thr Glu Tyr Pro Gly His Tyr Gly Glu Glu Met Asp Met Ile 
145                 150                 155                 160


Ser Tyr Asn Tyr Asp Tyr Tyr Ile Arg Gly Ala Thr Thr Thr Phe Ser 
                165                 170                 175


Ala Val Glu Arg Asp Arg Gln Trp Lys Phe Ile Met Cys Arg Met Thr 
            180                 185                 190


Glu Tyr Asp Cys Glu Phe Ala Asn Val 
        195                 200


<210>  98
<211>  748
<212>  DNA
<213>  Homo sapiens

<400>  98
catgacattg catccttcac ccatcacttg tgaatttttg ttttccacag ctctcatttc     60

tccaaaaatg tgtttgagcc acttggaaaa tatgccttta agccattcaa gaactcaagg    120

agctcagaga tcatcctgga agctgtggct cttttgctca atagttatgt tgctatttct    180

ttgctccttc agttggctaa tctttatttt tctccaatta gagactgcta aggagccctg    240

tatggctaag tttggaccat taccctcaaa atggcaaatg gcatcttctg aacctccttg    300

cgtgaataag gtgtctgact ggaagctgga gatacttcag aatggcttat atttaattta    360

tggccaagtg gctcccaatg caaactacaa tgatgtagct ccttttgagg tgcggctgta    420

taaaaacaaa gacatgatac aaactctaac aaacaaatct aaaatccaaa atgtaggagg    480

gacttatgaa ttgcatgttg gggacaccat agacttgata ttcaactctg agcatcaggt    540

tctaaaaaat aatacatact ggggtatcat tttactagca aatccccaat tcatctccta    600

gagacttgat ttgatctcct cattcccttc agcacatgta gaggtgccag tgggtggatt    660

ggagggagaa gatattcaat ttctagagtt tgtctgtcta caaaaatcaa cacaaacaga    720

actcctctgc acgtgaattt tcatctat                                       748


<210>  99
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Thr Leu His Pro Ser Pro Ile Thr Cys Glu Phe Leu Phe Ser Thr 
1               5                   10                  15


Ala Leu Ile Ser Pro Lys Met Cys Leu Ser His Leu Glu Asn Met Pro 
            20                  25                  30


Leu Ser His Ser Arg Thr Gln Gly Ala Gln Arg Ser Ser Trp Lys Leu 
        35                  40                  45


Trp Leu Phe Cys Ser Ile Val Met Leu Leu Phe Leu Cys Ser Phe Ser 
    50                  55                  60


Trp Leu Ile Phe Ile Phe Leu Gln Leu Glu Thr Ala Lys Glu Pro Cys 
65                  70                  75                  80


Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser 
                85                  90                  95


Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu 
            100                 105                 110


Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn 
        115                 120                 125


Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp 
    130                 135                 140


Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly 
145                 150                 155                 160


Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser 
                165                 170                 175


Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu 
            180                 185                 190


Ala Asn Pro Gln Phe Ile Ser 
        195


<210>  100
<211>  963
<212>  DNA
<213>  Homo sapiens

<400>  100
atgcatcaat gttccaacac ggtgaaccat tacgacaagc ccccagatct ctgcacgcac     60

ccacagcctg aatcatctgc tctgagcagc cagactcaca gacacgactg cagcaaacat    120

gggcacaaag caaaaaagca cagaaaactg gatgttccat ccctgggaaa ggacgcacaa    180

ccactctcgc acaaggagac tcaagccgga tcaaaaagca agtcacccta tgcagcctgg    240

cttcctctgt gctctttcct cccctacttc gagccccaat tcccagtcct gtcccaggaa    300

aggacccacc ctactcgctc tgacccgcaa ctccatagac acccagtcca ccctacagca    360

gtcccgagtc gcctccaaag gcacatgcag tttccttcac ggaaacttcg ctgcaagctc    420

agccactggc ccgcgcgccc tccccaccag cgatccgcgc acaaaacttc ccgaagccgg    480

ggacctgctg agccgcccgc gcccggaggc atggaagggc ggccagaggc cccaaggctt    540

gcgaaaaccc agcggctcga gcctgctccc ttctcggagc ctggctccgc tccccggcgg    600

cgcgtgagtc cccctcactg cttggtgaga accctgcatc ctcgagcggg atgctgccct    660

gagcgctgcg gcaaggggcg caacactcac accctaagtg ccaaagagcg cgggggcgtt    720

tcccacgcca ggacaattcc cacagaagtt gcaaaggaac ggacagagcg tgcagaggag    780

gaacaggcag cgcgtgcaga ggagattccg agaaggttag ggccaactac ggatctccaa    840

ggtccatgca tccccccaac acgtagaagc gcgggggcca gacccgtggc gccgccgggg    900

agtgcagcgc agccccgcag gcagtgcatg cggggcgcaa gacagacaca tctctggcag    960

taa                                                                  963


<210>  101
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  101

Met His Gln Cys Ser Asn Thr Val Asn His Tyr Asp Lys Pro Pro Asp 
1               5                   10                  15


Leu Cys Thr His Pro Gln Pro Glu Ser Ser Ala Leu Ser Ser Gln Thr 
            20                  25                  30


His Arg His Asp Cys Ser Lys His Gly His Lys Ala Lys Lys His Arg 
        35                  40                  45


Lys Leu Asp Val Pro Ser Leu Gly Lys Asp Ala Gln Pro Leu Ser His 
    50                  55                  60


Lys Glu Thr Gln Ala Gly Ser Lys Ser Lys Ser Pro Tyr Ala Ala Trp 
65                  70                  75                  80


Leu Pro Leu Cys Ser Phe Leu Pro Tyr Phe Glu Pro Gln Phe Pro Val 
                85                  90                  95


Leu Ser Gln Glu Arg Thr His Pro Thr Arg Ser Asp Pro Gln Leu His 
            100                 105                 110


Arg His Pro Val His Pro Thr Ala Val Pro Ser Arg Leu Gln Arg His 
        115                 120                 125


Met Gln Phe Pro Ser Arg Lys Leu Arg Cys Lys Leu Ser His Trp Pro 
    130                 135                 140


Ala Arg Pro Pro His Gln Arg Ser Ala His Lys Thr Ser Arg Ser Arg 
145                 150                 155                 160


Gly Pro Ala Glu Pro Pro Ala Pro Gly Gly Met Glu Gly Arg Pro Glu 
                165                 170                 175


Ala Pro Arg Leu Ala Lys Thr Gln Arg Leu Glu Pro Ala Pro Phe Ser 
            180                 185                 190


Glu Pro Gly Ser Ala Pro Arg Arg Arg Val Ser Pro Pro His Cys Leu 
        195                 200                 205


Val Arg Thr Leu His Pro Arg Ala Gly Cys Cys Pro Glu Arg Cys Gly 
    210                 215                 220


Lys Gly Arg Asn Thr His Thr Leu Ser Ala Lys Glu Arg Gly Gly Val 
225                 230                 235                 240


Ser His Ala Arg Thr Ile Pro Thr Glu Val Ala Lys Glu Arg Thr Glu 
                245                 250                 255


Arg Ala Glu Glu Glu Gln Ala Ala Arg Ala Glu Glu Ile Pro Arg Arg 
            260                 265                 270


Leu Gly Pro Thr Thr Asp Leu Gln Gly Pro Cys Ile Pro Pro Thr Arg 
        275                 280                 285


Arg Ser Ala Gly Ala Arg Pro Val Ala Pro Pro Gly Ser Ala Ala Gln 
    290                 295                 300


Pro Arg Arg Gln Cys Met Arg Gly Ala Arg Gln Thr His Leu Trp Gln 
305                 310                 315                 320


<210>  102
<211>  2432
<212>  DNA
<213>  Homo sapiens

<400>  102
aagcagcggc cgctcagtct gggcgcttgc aggctgctaa acccaaccgc agttgactag     60

cacctgctac cgcgcctttg cttcctggcg cacgcggagc ctcctggagc ctgccaccat    120

cctgcctact acgtgctgcc ctgcgcccgc agccatgtgc cgcaccctgg ccgccttccc    180

caccacctgc ctggagagag ccaaagagtt caagacacgt ctggggatct ttcttcacaa    240

atcagagctg ggctgcgata ctgggagtac tggcaagttc gagtggggca gtaaacacag    300

caaagagaat agaaacttct cagaagatgt gctggggtgg agagagtcgt tcgacctgct    360

gctgagcagt aaaaatggag tggctgcctt ccacgctttc ctgaagacag agttcagtga    420

ggagaacctg gagttctggc tggcctgtga ggagttcaag aagatccgat cagctaccaa    480

gctggcctcc agggcacacc agatctttga ggagttcatt tgcagtgagg cccctaaaga    540

ggtcaacatt gaccatgaga cccacgagct gacgaggatg aacctgcaga ctgccacagc    600

cacatgcttt gatgcggctc aggggaagac acgtaccctg atggagaagg actcctaccc    660

acgcttcctg aagtcgcctg cttaccggga cctggctgcc caagcctcag ccgcctctgc    720

cactctgtcc agctgcagcc tggacgagcc ctcacacacc tgagtctcca cggcagtgag    780

gaagccagcc gggaagagag gttgagtcac ccatccccga ggtggctgcc cctgtgtggg    840

aggcaggttc tgcaaagcaa gtgcaagagg acaaaaaaaa aaaaaaaaaa aaaaaaaatg    900

cgctccagca gcctgtttgg gaagcagcag tctctccttc agatactgtg ggactcatgc    960

tggagaggag ccgcccactt ccaggacctg tgaataaggg ctaatgatga gggttggtgg   1020

ggctctctgt ggggcaaaaa ggtggtatgg gggttagcac tggctctcgt tctcaccgga   1080

gaaggaagtg ttctagtgtg gtttaggaaa catgtggata aagggaacca tgaaaatgag   1140

aggaggaaag acatccagat cagctgtttt gcctgttgct cagttgactc tgattgcatc   1200

ctgttttcct aattcccaga ctgttctggg cacggaaggg accctggatg tggagtcttc   1260

ccctttggcc ctcctcactg gcctctgggc tagcccagag tcccttagct tgtacctcgt   1320

aacactcctg tgtgtctgtc cagccttgca gtcatgtcaa ggccagcaag ctgatgtgac   1380

tcttgcccca tgcgagatat ttatacctca aacactggcc tgtgagccct ttccaagtca   1440

gtggagagcc ctgaaaggag gctcacttga atccagctca gtgctctggg tggccccctg   1500

caggtggccc ctgaccctgc gttgcagcag ggtccacctg tgagcaggcc cgccctgggg   1560

cctcttcctg gatgtgccct ctctgagttc tgtgctgtct cttggaggca gggcccagga   1620

gaacaaagtg tggaggcctc ggggagtggc ttttccagct ctcatgcccc gcagtgtgga   1680

acaaggcaga aaaggatcct aggaaataag tctcttggcg gtccctgaga gtcctgctga   1740

aatccagcca gtgttttttg tggtatgaga acaggcaaaa agagatgccc cgagatagaa   1800

ggggagcctt gtgtttcttt cctgcagacg tgagatgaac actggagtgg gcagaggtgg   1860

cccaggacca tggcaccctt agagtgcaga agctgggggg agaggctgct tcgaagggca   1920

ggactgggga taatcagaac ctgcctgtca cctcagggca tcactgaaca aacatttcct   1980

gatggcaact cctgcggcag agcccaggct ggggaagtga actacccagg gcagcccctt   2040

tgtggcccag gataatcaac actgttctct ctgtaccatg agctcctcca ggagattatt   2100

taagtgtatt gtatcattgg ttttctgtga ttgtcataac attgtttttg ttattgttgg   2160

tgctgttgtt atttattatt gtaatttcag tttgcctcta ctggagaatc tcagcagggg   2220

tttcagcctg actgtctccc tttctctacc agactctacc tctgaatgtg ctgggaacct   2280

cttggagcct gtcaggaact cctcactgtt taaatattta tttattgtga caaatggagc   2340

tggtttccta gatatgaatg atgtttgcaa tccccatttt cctgtttcag catgttatat   2400

tcttataaaa taaaagcaaa agtcaaatat ga                                 2432


<210>  103
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Cys Arg Thr Leu Ala Ala Phe Pro Thr Thr Cys Leu Glu Arg Ala 
1               5                   10                  15


Lys Glu Phe Lys Thr Arg Leu Gly Ile Phe Leu His Lys Ser Glu Leu 
            20                  25                  30


Gly Cys Asp Thr Gly Ser Thr Gly Lys Phe Glu Trp Gly Ser Lys His 
        35                  40                  45


Ser Lys Glu Asn Arg Asn Phe Ser Glu Asp Val Leu Gly Trp Arg Glu 
    50                  55                  60


Ser Phe Asp Leu Leu Leu Ser Ser Lys Asn Gly Val Ala Ala Phe His 
65                  70                  75                  80


Ala Phe Leu Lys Thr Glu Phe Ser Glu Glu Asn Leu Glu Phe Trp Leu 
                85                  90                  95


Ala Cys Glu Glu Phe Lys Lys Ile Arg Ser Ala Thr Lys Leu Ala Ser 
            100                 105                 110


Arg Ala His Gln Ile Phe Glu Glu Phe Ile Cys Ser Glu Ala Pro Lys 
        115                 120                 125


Glu Val Asn Ile Asp His Glu Thr His Glu Leu Thr Arg Met Asn Leu 
    130                 135                 140


Gln Thr Ala Thr Ala Thr Cys Phe Asp Ala Ala Gln Gly Lys Thr Arg 
145                 150                 155                 160


Thr Leu Met Glu Lys Asp Ser Tyr Pro Arg Phe Leu Lys Ser Pro Ala 
                165                 170                 175


Tyr Arg Asp Leu Ala Ala Gln Ala Ser Ala Ala Ser Ala Thr Leu Ser 
            180                 185                 190


Ser Cys Ser Leu Asp Glu Pro Ser His Thr 
        195                 200


<210>  104
<211>  1791
<212>  DNA
<213>  Homo sapiens

<400>  104
cccagaaatt ctacccaagc tccctcagca ccatgtaccg agcacttcgg ctcctcgcgc     60

gctcgcgtcc cctcgtgcgg gctccagccg cagccttagc ttcggctccc ggcttgggtg    120

gcgcggccgt gccctcgttt tggcctccga acgcggctcg aatggcaagc caaaattcct    180

tccggataga atatgatacc tttggtgaac taaaggtgcc aaatgataag tattatggcg    240

cccagaccgt gagatctacg atgaacttta agattggagg tgtgacagaa cgcatgccaa    300

ccccagttat taaagctttt ggcatcttga agcgagcggc cgctgaagta aaccaggatt    360

atggtcttga tccaaagatt gctaatgcaa taatgaaggc agcagatgag gtagctgaag    420

gtaaattaaa tgatcatttt cctctcgtgg tatggcagac tggatcagga actcagacaa    480

atatgaatgt aaatgaagtc attagcaata gagcaattga aatgttagga ggtgaacttg    540

gcagcaagat acctgtgcat cccaacgatc atgttaataa aagccagagc tcaaatgata    600

cttttcccac agcaatgcac attgctgctg caatagaagt tcatgaagta ctgttaccag    660

gactacagaa gttacatgat gctcttgatg caaaatccaa agagtttgca cagatcatca    720

agattggacg tactcatact caggatgctg ttccacttac tcttgggcag gaatttagtg    780

gttatgttca acaagtaaaa tatgcaatga caagaataaa agctgccatg ccaagaatct    840

atgagctcgc agctggaggc actgctgttg gtacaggttt aaatactaga attggctttg    900

cagaaaaggt tgctgcaaaa gtggctgcac ttacaggctt gccttttgtc actgctccga    960

ataaatttga agctctggct gctcatgacg ctctggttga gctcagtgga gccatgaaca   1020

ctactgcctg cagtctgatg aagatagcaa atgatattcg atttttgggt tctggtcctc   1080

ggtcaggtct gggagaattg atcttgcctg aaaatgaacc aggaagcagt atcatgccag   1140

gcaaggtgaa ccctactcag tgtgaagcaa tgaccatggt tgcagcccaa gtcatgggga   1200

accatgttgc tgtcactgtc ggaggcagca atggacattt tgagttgaat gttttcaagc   1260

caatgatgat taaaaatgtg ttacactcag ccaggctgct gggggatgct tcagtttcct   1320

ttacagaaaa ctgcgtggtg ggaatccagg ccaatacaga aaggatcaac aagctgatga   1380

atgagtctct aatgttggtg acagctctca atcctcatat agggtatgac aaggcagcaa   1440

agattgctaa gacagcacac aaaaatggat caaccttaaa ggaaactgct atcgaacttg   1500

gctatctcac agcagagcag tttgacgaat gggtaaaacc taaggacatg ctgggtccaa   1560

agtgatttac ataaatttat aatgaaaata aacatgtata aaatttaaaa aaacagactc   1620

ccatttctta aaaacggata agtttgaaag gaaactgcta ttgaacttaa gcatctctag   1680

cagagcaatt tgatcagtat ataaaaccct aggatgtgct aggtctaaga tggattaaac   1740

aagtataaaa taaaatacat ttataaaata aaaaggaaaa cagacttaaa a            1791


<210>  105
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Tyr Arg Ala Leu Arg Leu Leu Ala Arg Ser Arg Pro Leu Val Arg 
1               5                   10                  15


Ala Pro Ala Ala Ala Leu Ala Ser Ala Pro Gly Leu Gly Gly Ala Ala 
            20                  25                  30


Val Pro Ser Phe Trp Pro Pro Asn Ala Ala Arg Met Ala Ser Gln Asn 
        35                  40                  45


Ser Phe Arg Ile Glu Tyr Asp Thr Phe Gly Glu Leu Lys Val Pro Asn 
    50                  55                  60


Asp Lys Tyr Tyr Gly Ala Gln Thr Val Arg Ser Thr Met Asn Phe Lys 
65                  70                  75                  80


Ile Gly Gly Val Thr Glu Arg Met Pro Thr Pro Val Ile Lys Ala Phe 
                85                  90                  95


Gly Ile Leu Lys Arg Ala Ala Ala Glu Val Asn Gln Asp Tyr Gly Leu 
            100                 105                 110


Asp Pro Lys Ile Ala Asn Ala Ile Met Lys Ala Ala Asp Glu Val Ala 
        115                 120                 125


Glu Gly Lys Leu Asn Asp His Phe Pro Leu Val Val Trp Gln Thr Gly 
    130                 135                 140


Ser Gly Thr Gln Thr Asn Met Asn Val Asn Glu Val Ile Ser Asn Arg 
145                 150                 155                 160


Ala Ile Glu Met Leu Gly Gly Glu Leu Gly Ser Lys Ile Pro Val His 
                165                 170                 175


Pro Asn Asp His Val Asn Lys Ser Gln Ser Ser Asn Asp Thr Phe Pro 
            180                 185                 190


Thr Ala Met His Ile Ala Ala Ala Ile Glu Val His Glu Val Leu Leu 
        195                 200                 205


Pro Gly Leu Gln Lys Leu His Asp Ala Leu Asp Ala Lys Ser Lys Glu 
    210                 215                 220


Phe Ala Gln Ile Ile Lys Ile Gly Arg Thr His Thr Gln Asp Ala Val 
225                 230                 235                 240


Pro Leu Thr Leu Gly Gln Glu Phe Ser Gly Tyr Val Gln Gln Val Lys 
                245                 250                 255


Tyr Ala Met Thr Arg Ile Lys Ala Ala Met Pro Arg Ile Tyr Glu Leu 
            260                 265                 270


Ala Ala Gly Gly Thr Ala Val Gly Thr Gly Leu Asn Thr Arg Ile Gly 
        275                 280                 285


Phe Ala Glu Lys Val Ala Ala Lys Val Ala Ala Leu Thr Gly Leu Pro 
    290                 295                 300


Phe Val Thr Ala Pro Asn Lys Phe Glu Ala Leu Ala Ala His Asp Ala 
305                 310                 315                 320


Leu Val Glu Leu Ser Gly Ala Met Asn Thr Thr Ala Cys Ser Leu Met 
                325                 330                 335


Lys Ile Ala Asn Asp Ile Arg Phe Leu Gly Ser Gly Pro Arg Ser Gly 
            340                 345                 350


Leu Gly Glu Leu Ile Leu Pro Glu Asn Glu Pro Gly Ser Ser Ile Met 
        355                 360                 365


Pro Gly Lys Val Asn Pro Thr Gln Cys Glu Ala Met Thr Met Val Ala 
    370                 375                 380


Ala Gln Val Met Gly Asn His Val Ala Val Thr Val Gly Gly Ser Asn 
385                 390                 395                 400


Gly His Phe Glu Leu Asn Val Phe Lys Pro Met Met Ile Lys Asn Val 
                405                 410                 415


Leu His Ser Ala Arg Leu Leu Gly Asp Ala Ser Val Ser Phe Thr Glu 
            420                 425                 430


Asn Cys Val Val Gly Ile Gln Ala Asn Thr Glu Arg Ile Asn Lys Leu 
        435                 440                 445


Met Asn Glu Ser Leu Met Leu Val Thr Ala Leu Asn Pro His Ile Gly 
    450                 455                 460


Tyr Asp Lys Ala Ala Lys Ile Ala Lys Thr Ala His Lys Asn Gly Ser 
465                 470                 475                 480


Thr Leu Lys Glu Thr Ala Ile Glu Leu Gly Tyr Leu Thr Ala Glu Gln 
                485                 490                 495


Phe Asp Glu Trp Val Lys Pro Lys Asp Met Leu Gly Pro Lys 
            500                 505                 510


<210>  106
<211>  4992
<212>  DNA
<213>  Homo sapiens

<400>  106
cagaagcaac aataattgtg aaaaatactt cagcagttat ggactcatct gtcattcaaa     60

ggaaaaaagt agctgtcatt ggtggtggct tggttggctc attacaagca tgctttcttg    120

caaagaggaa tttccagatt gatgtatatg aagctaggga agatactcga gtggctacct    180

tcacacgtgg aagaagcatt aacttagccc tttctcatag aggacgacaa gccttgaaag    240

ctgttggcct ggaagatcag attgtatccc aaggtattcc catgagagca agaatgatcc    300

actctctttc aggaaaaaag tctgcaattc cctatgggac aaagtctcag tatattcttt    360

ctgtaagcag agaaaatcta aacaaggatc tattgactgc tgctgagaaa taccccaatg    420

tgaaaatgca ctttaaccac aggctgttga aatgtaatcc agaggaagga atgatcacag    480

tgcttggatc tgacaaagtt cccaaagatg tcacttgtga cctcattgta ggatgtgatg    540

gagcctattc aactgtcaga tctcacctga tgaagaaacc tcgctttgat tacagtcagc    600

agtacattcc tcatgggtac atggagttga ctattccacc taagaacgga gattatgcca    660

tggaacctaa ttatctgcat atttggccta gaaatacctt tatgatgatt gcacttccta    720

acatgaacaa atcattcaca tgtactttgt tcatgccctt tgaagagttt gaaaaacttc    780

taaccagtaa tgatgtggta gatttcttcc agaaatactt tccggatgcc atccctctaa    840

ttggagagaa actcctagtg caagatttct tcctgttgcc tgcccagccc atgatatctg    900

taaagtgctc ttcatttcac tttaaatctc actgtgtact gctgggagat gcagctcatg    960

ctatagtgcc gttttttggg caaggaatga atgcgggctt tgaagactgc ttggtatttg   1020

atgagttaat ggataaattc agtaacgacc ttagtttgtg tcttcctgtg ttctcaagat   1080

tgagaatccc agatgatcac gcgatttcag acctatccat gtacaattac atagagatgc   1140

gagcacatgt caactcaagc tggttcattt ttcagaagaa catggagaga tttcttcatg   1200

cgattatgcc atcgaccttt atccctctct atacaatggt cactttttcc agaataagat   1260

accatgaggc tgtgcagcgt tggcattggc aaaaaaaggt gataaacaaa ggactctttt   1320

tcttgggatc actgatagcc atcagcagta cctacctact tatacactac atgtcaccac   1380

gatctttcct ctgcttgaga agaccatgga actggatagc tcacttccgg aatacaacat   1440

gtttccccgc aaaggccgtg gactccctag aacaaatttc caatctcatt agcaggtgat   1500

agaaaggttt tgtggtagca aatgcatgat ttctctgtga ccaaaattaa gcatgaaaaa   1560

aatgtttcca ttgccatatt tgattcacta gtggaagata gtgttctgct tataattaaa   1620

ctgaatgtag agtatctctg tatgttaatt gcaattactg gttggggggt gcattttaaa   1680

agatgaaaca tgcagcttcc ctacattaca cacactcagg ttgagtcatt ctaactataa   1740

aagtgcaatg actaagatcc ttcacttctc tgaaagtaag gccctagatg cctcagggaa   1800

gacagtaatc atgccttttc tttaaaagac acaataggac tcgcaacagc attgactcaa   1860

cacctaggac taaaaatcac aacttaacta gcatgttaac tgcacttttc attacgtgaa   1920

tggaacttac ctaaccacag ggctcagact tactagataa aaccagaaat ggaaataagg   1980

aattcagggg agttccagag acttacaaaa tgaactcatt ttattttccc accttcaaat   2040

ataagtatta tcatctatct gtttatcgtc tatctatcta tcatctatct atctatctat   2100

catctatcta tctatctatc tatctatcta tctatctatc tatctatcta tctctattta   2160

tttatgtatt tagagatcag gtctcactct gttgaccagg ctggagtgca gtggtgagat   2220

ctgggttcac tgcaacctct gcctcctggg ctcaagcaat cctcccactt cagcctccca   2280

aatagctggg gctaccatgg tatttttcag tagagaccgg gtcttgccat gctgcccagg   2340

ccagtctcaa actcctggcc tcatgtgatc tgcccacctc agcctcccaa agtacaggga   2400

ttagagttgt gagccaccgc tgccagccca gagttaccct ctaaagataa gaaaaaggct   2460

attaatatca tactaagtga aggacaggaa agggttttat tcataaatta aatgtctaca   2520

tgtgccagaa tggaaaggaa acaaggggag acaactttta tagaaataca aagccattac   2580

tttattcaat ttcagaccct cagaagcaat ttactaattt attcttcgac tacatactgc   2640

agcagaacca gcaatacact tgatttttaa aagcacattt agtgaaatgt tttctttggt   2700

tcatccttct ttaacaggct gctgagtcac tcagaaatcc ttcaaacatg attaattatg   2760

aagatgaaac actagagtca tataagaaat aaaaattggg caataaaata aaatgattca   2820

gtgtttcttt tctatattgt caatgaaaac cttgagttct aataatccat gttcagtttg   2880

tagggaaaga aaaaataatt tttccttcta cccactttag gttccttggc tggggcccct   2940

ataacaaaag acagattgac aagagaaaaa caaacataaa tttattagcg ggtatatgta   3000

atatatatgt gggaaataca ggggaatgag caaatctcaa agagctggcg tcttagaact   3060

ccctggctta tatagcatcg acaaagaaca gtaaattttt agagaaacaa caaaacaaag   3120

aaaaagagct ttgagtctgt aggggcagca atttggggga agcaaatata tgggagtttg   3180

ccttgtagat tcctctggtg gtggtctcca ggctgacaag gattcaaagt tgtctctgaa   3240

actcctcttt gtcatactgc acatataaaa cgtcttttgt ttccaacaag aggatttctt   3300

tttcattcta gaattatctc cttgataact tgatcagata taggacatga cactgaatag   3360

agtccaacag tacaaaaaaa attcagtatg ttctagctac ttcacacatg tgtacgcgac   3420

agttattttt acagtaaggt attttcgaga aaaatgcatt acgtgttttg gaaaatagag   3480

taatttaaaa aatatatttg aaatgaaaat ctccaacaca ttagaagatg atgatgttag   3540

atgcccatcg tgtgccacaa gtggtttttt cattatgtaa agcacccgtt gaattaaaag   3600

aatttgtttt tgttcaacct cttcctgagg cccaagagca tatgggcaat tcggatttcc   3660

tgctggacca caaggttctg ttgatattac atagaaacgg gtattccaga cacttcttat   3720

gatgaaagtc caaaagtggc atccaattta aggccccatc tttcgttgcc attcttcatt   3780

cctacaaagg acgaacttgg attacatcaa ctttggaccc attggttttg tcgctgtcgt   3840

caactgacag tgattcacca ctggtgatga taaaaatgat ggaagaagag ttgaaagtca   3900

cttttttctt tggcctgtcc ccatctttct gtgacatcac aatgggtctg atctgcattt   3960

cacttccagc tgctggtagg tctttagcag gcctctggca cctcagcagt cggaggcaca   4020

gaagctgcaa aagggatctt cgaaactggg cagagaaaaa ataaagtgga atattaagta   4080

aaagttgggc actaatctgg attaacattc gaggaaatca gttgagctga tttaagttgt   4140

tttttgtttg ttagcaggtg tggatgtggg gttatgtggt catgctcaga tctacctaaa   4200

tcaccccaga gctttatgtc ttttattcat tctaaatctt attaaccgga atatgtagga   4260

ccatttcaat accttgtaat cctccaagct tcaatctgca cacactttct atgagggcag   4320

gtacaactat taagagattt tgaacattaa gttagtccac aaatattcag tgggcatcta   4380

ctaggtgaca gccactgtgc tataattaga gactttttac tataagcatc aaaaacagat   4440

aaggctcttc ctggcagagt ttacagcctg gtgtacttgc taatgtctct ttaattaggt   4500

gaagaatttt ttttttctat cgaaattact aatcagttgg ggaaaaaaat actatagcag   4560

acagcactaa tgtcatcaac aaacattgtt cttctccgtg tcctgggtac aacatcgaat   4620

aatatttctt ggcctccttt ccgcttctcc tctctgctgt tcctctctac aagaacctgg   4680

gaggccaacg cctaaagatc ataatatcac aatggaagga acctagattc ctaaatgact   4740

gcataggaca gatcccatct cctccaccca atacattatt agactgaact gtgacctgaa   4800

atgagcaata aactctgtat taattcactg aaatgttggg gttgcttgtt atagtagtcg   4860

gtccatcatg accagtaaaa cataaatcaa aagttaatgt aattgttatc ccattattta   4920

gagcgaaata aatgttgaat atatggactt tctcagatta ggaaatacca attaaaaata   4980

taataaatag ct                                                       4992


<210>  107
<211>  486
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Asp Ser Ser Val Ile Gln Arg Lys Lys Val Ala Val Ile Gly Gly 
1               5                   10                  15


Gly Leu Val Gly Ser Leu Gln Ala Cys Phe Leu Ala Lys Arg Asn Phe 
            20                  25                  30


Gln Ile Asp Val Tyr Glu Ala Arg Glu Asp Thr Arg Val Ala Thr Phe 
        35                  40                  45


Thr Arg Gly Arg Ser Ile Asn Leu Ala Leu Ser His Arg Gly Arg Gln 
    50                  55                  60


Ala Leu Lys Ala Val Gly Leu Glu Asp Gln Ile Val Ser Gln Gly Ile 
65                  70                  75                  80


Pro Met Arg Ala Arg Met Ile His Ser Leu Ser Gly Lys Lys Ser Ala 
                85                  90                  95


Ile Pro Tyr Gly Thr Lys Ser Gln Tyr Ile Leu Ser Val Ser Arg Glu 
            100                 105                 110


Asn Leu Asn Lys Asp Leu Leu Thr Ala Ala Glu Lys Tyr Pro Asn Val 
        115                 120                 125


Lys Met His Phe Asn His Arg Leu Leu Lys Cys Asn Pro Glu Glu Gly 
    130                 135                 140


Met Ile Thr Val Leu Gly Ser Asp Lys Val Pro Lys Asp Val Thr Cys 
145                 150                 155                 160


Asp Leu Ile Val Gly Cys Asp Gly Ala Tyr Ser Thr Val Arg Ser His 
                165                 170                 175


Leu Met Lys Lys Pro Arg Phe Asp Tyr Ser Gln Gln Tyr Ile Pro His 
            180                 185                 190


Gly Tyr Met Glu Leu Thr Ile Pro Pro Lys Asn Gly Asp Tyr Ala Met 
        195                 200                 205


Glu Pro Asn Tyr Leu His Ile Trp Pro Arg Asn Thr Phe Met Met Ile 
    210                 215                 220


Ala Leu Pro Asn Met Asn Lys Ser Phe Thr Cys Thr Leu Phe Met Pro 
225                 230                 235                 240


Phe Glu Glu Phe Glu Lys Leu Leu Thr Ser Asn Asp Val Val Asp Phe 
                245                 250                 255


Phe Gln Lys Tyr Phe Pro Asp Ala Ile Pro Leu Ile Gly Glu Lys Leu 
            260                 265                 270


Leu Val Gln Asp Phe Phe Leu Leu Pro Ala Gln Pro Met Ile Ser Val 
        275                 280                 285


Lys Cys Ser Ser Phe His Phe Lys Ser His Cys Val Leu Leu Gly Asp 
    290                 295                 300


Ala Ala His Ala Ile Val Pro Phe Phe Gly Gln Gly Met Asn Ala Gly 
305                 310                 315                 320


Phe Glu Asp Cys Leu Val Phe Asp Glu Leu Met Asp Lys Phe Ser Asn 
                325                 330                 335


Asp Leu Ser Leu Cys Leu Pro Val Phe Ser Arg Leu Arg Ile Pro Asp 
            340                 345                 350


Asp His Ala Ile Ser Asp Leu Ser Met Tyr Asn Tyr Ile Glu Met Arg 
        355                 360                 365


Ala His Val Asn Ser Ser Trp Phe Ile Phe Gln Lys Asn Met Glu Arg 
    370                 375                 380


Phe Leu His Ala Ile Met Pro Ser Thr Phe Ile Pro Leu Tyr Thr Met 
385                 390                 395                 400


Val Thr Phe Ser Arg Ile Arg Tyr His Glu Ala Val Gln Arg Trp His 
                405                 410                 415


Trp Gln Lys Lys Val Ile Asn Lys Gly Leu Phe Phe Leu Gly Ser Leu 
            420                 425                 430


Ile Ala Ile Ser Ser Thr Tyr Leu Leu Ile His Tyr Met Ser Pro Arg 
        435                 440                 445


Ser Phe Leu Cys Leu Arg Arg Pro Trp Asn Trp Ile Ala His Phe Arg 
    450                 455                 460


Asn Thr Thr Cys Phe Pro Ala Lys Ala Val Asp Ser Leu Glu Gln Ile 
465                 470                 475                 480


Ser Asn Leu Ile Ser Arg 
                485


<210>  108
<211>  2632
<212>  DNA
<213>  Homo sapiens

<400>  108
gggcccggcg cgcggtagcg cgggcccctc agtgcacaat ggctagagca ggcggcggag     60

ccccaacccc acccagtgcg gagcgcgccg cgagccccgc cgcaagctga gcgcctccgc    120

ccgccaggcg cgccggcgcc gggccatgta ctcggggaac cgcagcggcg gccacggcta    180

ctgggacggc ggcggggccg cgggcgctga ggggccggcg ccggcgggga cactgagccc    240

cgcgcccctc ttcagccccg gcacctacga gcgcctggcg ctgctgctgg gctccattgg    300

gctgctgggc gtcggcaaca acctgctggt gctcgtcctc tactacaagt tccagcggct    360

ccgcactccc actcacctcc tcctggtcaa catcagcctc agcgacctgc tggtgtccct    420

cttcggggtc acctttacct tcgtgtcctg cctgaggaac ggctgggtgt gggacaccgt    480

gggctgcgtg tgggacgggt ttagcggcag cctcttcggg attgtttcca ttgccaccct    540

aaccgtgctg gcctatgaac gttacattcg cgtggtccat gccagagtga tcaatttttc    600

ctgggcctgg agggccatta cctacatctg gctctactca ctggcgtggg caggagcacc    660

tctcctggga tggaacaggt acatcctgga cgtacacgga ctaggctgca ctgtggactg    720

gaaatccaag gatgccaacg attcctcctt tgtgcttttc ttatttcttg gctgcctggt    780

ggtgcccctg ggtgtcatag cccattgcta tggccatatt ctatattcca ttcgaatgct    840

tcgttgtgtg gaagatcttc agacaattca agtgatcaag attttaaaat atgaaaagaa    900

actggccaaa atgtgctttt taatgatatt caccttcctg gtctgttgga tgccttatat    960

cgtgatctgc ttcttggtgg ttaatggtca tggtcacctg gtcactccaa caatatctat   1020

tgtttcgtac ctctttgcta aatcgaacac tgtatacaat ccagtgattt atgtcttcat   1080

gatcagaaag tttcgaagat cccttttgca gcttctgtgc ctccgactgc tgaggtgcca   1140

gaggcctgct aaagacctac cagcagctgg aagtgaaatg cagatcagac ccattgtgat   1200

gtcacagaaa gatggggaca ggccaaagaa aaaagtgact ttcaactctt cttccatcat   1260

ttttatcatc accagtgatg aatcactgtc agttgacgac agcgacaaaa ccaatgggtc   1320

caaagttgat gtaatccaag ttcgtccttt gtaggaatga agaatggcaa cgaaagatgg   1380

ggccttaaat tggatgccac ttttggactt tcatcataag aagtgtctgg aatacccgtt   1440

ctatgtaata tcaacagaac cttgtggtcc agcaggaaat ccgaattgcc catatgctct   1500

tgggcctcag gaagaggttg aacaaaaaca aattctttta attcaacggg tgctttacat   1560

aatgaaaaaa ccacttgtgg cacacgatgg gcatctaaca tcatcatctt ctaatgtgtt   1620

ggagattttc atttcaaata tattttttaa attactctat tttccaaaac acgtaatgca   1680

tttttctcga aaatacctta ctgtaaaaat aactgtcgcg tacacatgtg tgaagtagct   1740

agaacatact gaattttttt tgtactgttg gactctattc agtgtcatgt cctatatctg   1800

atcaagttat caaggagata attctagaat gaaaaagaaa atcctcttgt tggaaacaaa   1860

agacgtttta tatgtgcagt atgacaaaga ggagtttcag agacaacttt gaatccttgt   1920

cagcctggag accagcacca gaggaatcta caaggcaaac tcccatatat ttgcttcccc   1980

caaattgctg cccctacaga ctcaaagctc tttttctttg ttttgttgtt tctctaaaaa   2040

tttactgttc tttgtcgatg ctatataagc cagggagttc taagacgcca gctctttgag   2100

atttgctcat tcccctgtat ttcccacata tatattacat atacccgcta ataaatttat   2160

gtttgttttt ctcttgtcaa tctgtctttt gttatagggg ccccagccaa ggaacctaaa   2220

gtgggtagaa ggaaaaatta ttttttcttt ccctacaaac tgaacatgga ttattagaac   2280

tcaaggtttt cattgacaat atagaaaaga aacactgaat cattttattt tattgcccaa   2340

tttttatttc ttatatgact ctagtgtttc atcttcataa ttaatcatgt ttgaaggatt   2400

tctgagtgac tcagcagcct gttaaagaag gatgaaccaa agaaaacatt tcactaaatg   2460

tgcttttaaa aatcaagtgt attgctggtt ctgctgcagt atgtagtcga agaataaatt   2520

agtaaattgc ttctgagggt ctgaaattga ataaagtaat ggctttgtat ttctataaaa   2580

gttgtctccc cttgtttcct ttccattctg gcacatgtag acatttaatt ta           2632


<210>  109
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Tyr Ser Gly Asn Arg Ser Gly Gly His Gly Tyr Trp Asp Gly Gly 
1               5                   10                  15


Gly Ala Ala Gly Ala Glu Gly Pro Ala Pro Ala Gly Thr Leu Ser Pro 
            20                  25                  30


Ala Pro Leu Phe Ser Pro Gly Thr Tyr Glu Arg Leu Ala Leu Leu Leu 
        35                  40                  45


Gly Ser Ile Gly Leu Leu Gly Val Gly Asn Asn Leu Leu Val Leu Val 
    50                  55                  60


Leu Tyr Tyr Lys Phe Gln Arg Leu Arg Thr Pro Thr His Leu Leu Leu 
65                  70                  75                  80


Val Asn Ile Ser Leu Ser Asp Leu Leu Val Ser Leu Phe Gly Val Thr 
                85                  90                  95


Phe Thr Phe Val Ser Cys Leu Arg Asn Gly Trp Val Trp Asp Thr Val 
            100                 105                 110


Gly Cys Val Trp Asp Gly Phe Ser Gly Ser Leu Phe Gly Ile Val Ser 
        115                 120                 125


Ile Ala Thr Leu Thr Val Leu Ala Tyr Glu Arg Tyr Ile Arg Val Val 
    130                 135                 140


His Ala Arg Val Ile Asn Phe Ser Trp Ala Trp Arg Ala Ile Thr Tyr 
145                 150                 155                 160


Ile Trp Leu Tyr Ser Leu Ala Trp Ala Gly Ala Pro Leu Leu Gly Trp 
                165                 170                 175


Asn Arg Tyr Ile Leu Asp Val His Gly Leu Gly Cys Thr Val Asp Trp 
            180                 185                 190


Lys Ser Lys Asp Ala Asn Asp Ser Ser Phe Val Leu Phe Leu Phe Leu 
        195                 200                 205


Gly Cys Leu Val Val Pro Leu Gly Val Ile Ala His Cys Tyr Gly His 
    210                 215                 220


Ile Leu Tyr Ser Ile Arg Met Leu Arg Cys Val Glu Asp Leu Gln Thr 
225                 230                 235                 240


Ile Gln Val Ile Lys Ile Leu Lys Tyr Glu Lys Lys Leu Ala Lys Met 
                245                 250                 255


Cys Phe Leu Met Ile Phe Thr Phe Leu Val Cys Trp Met Pro Tyr Ile 
            260                 265                 270


Val Ile Cys Phe Leu Val Val Asn Gly His Gly His Leu Val Thr Pro 
        275                 280                 285


Thr Ile Ser Ile Val Ser Tyr Leu Phe Ala Lys Ser Asn Thr Val Tyr 
    290                 295                 300


Asn Pro Val Ile Tyr Val Phe Met Ile Arg Lys Phe Arg Arg Ser Leu 
305                 310                 315                 320


Leu Gln Leu Leu Cys Leu Arg Leu Leu Arg Cys Gln Arg Pro Ala Lys 
                325                 330                 335


Asp Leu Pro Ala Ala Gly Ser Glu Met Gln Ile Arg Pro Ile Val Met 
            340                 345                 350


Ser Gln Lys Asp Gly Asp Arg Pro Lys Lys Lys Val Thr Phe Asn Ser 
        355                 360                 365


Ser Ser Ile Ile Phe Ile Ile Thr Ser Asp Glu Ser Leu Ser Val Asp 
    370                 375                 380


Asp Ser Asp Lys Thr Asn Gly Ser Lys Val Asp Val Ile Gln Val Arg 
385                 390                 395                 400


Pro Leu 



<210>  110
<211>  7082
<212>  DNA
<213>  Homo sapiens

<400>  110
ataagaaaaa aaatatttta aaagggtaac cgttaaacag ctaggacctg caacttcagt     60

gcttctggga taactggaac atcagaagga cagattttat tacagcataa tcacacctca    120

tttctttcat cagcagttgt caccagacgc tgttacttcc taaaatggcg gacaatcttc    180

ccacagagtt tgatgtggtt ataataggga caggtttgcc cgaatccatc cttgcagctg    240

catgttcaag aagtggtcag agggttctgc atattgattc aagaagctac tatggaggaa    300

actgggctag tttcagcttt tcaggattgc tatcctggtt gaaggagtat cagcaaaaca    360

atgacattgg ggaagaaagt actgttgtat ggcaggacct gatccatgaa acagaagaag    420

ccatcactct tcgcaagaag gatgaaacta ttcaacacac agaagctttt tgctacgcca    480

gtcaggatat ggaggacaac gttgaagaga ttggtgctct gcagaaaaat ccttctttgg    540

gggtgtctaa taccttcact gaagttctgg attctgcatt acctgaagaa agccagttat    600

cgtattttaa tagcgacgaa atgcctgcaa aacacactca gaaaagtgat acagagattt    660

cactagaagt aactgatgta gaggaatcag tggagaagga aaagtattgt ggagataaaa    720

cttgtatgca cacagtttca gataaagatg gagataaaga tgaaagcaaa tctacagtag    780

aagataaggc cgatgaacca attagaaata ggattactta ctctcaaata gttaaagaag    840

gcaggaggtt taatattgat ttggtgtcaa aactgctgta ttctcaagga ttgctaattg    900

atcttttaat caaatcagat gttagtcgtt atgtagaatt taaaaatgtc actaggattc    960

ttgcatttcg ggaaggaaag gtagaacaag ttccttgttc cagagcagat gtctttaata   1020

gcaaggaact caccatggtt gaaaagagga tgctaatgaa atttctcaca ttttgtttag   1080

agtatgaaca acatcctgat gaataccaag ctttcaggca gtgttcattt tcagaatact   1140

taaaaactaa aaaactaact cccaaccttc aacattttgt actgcactca attgcaatga   1200

catcagaatc atcttgcact acaatagatg gtcttaacgc aactaaaaac ttccttcagt   1260

gtctcggacg gtttggcaac accccctttt tatttccctt gtatggccaa ggagaaattc   1320

cccagggttt ctgtaggatg tgtgcagttt ttggtggaat ctattgtctt cgtcataaag   1380

tacaatgctt tgtagtcgac aaagaatctg gacgatgtaa agcaattata gatcactttg   1440

gtcaaagaat aaatgctaaa tattttattg tggaagacag ttacctttct gaggaaacat   1500

gctcaaatgt gcagtataag cagatctcta gggcagtact cattacagat cagtctatac   1560

taaagacaga tttagatcag cagacttcca ttctgatagt tcctccagca gagccaggag   1620

cttgtgctgt acgggtcaca gaattatgtt cttcaaccat gacatgcatg aaggacacct   1680

atctggtaca tttgacatgt tcatcttcta aaacagcaag agaagactta gaatcagtgg   1740

tgaagaaatt attcactccg tatactgaaa cagaaataaa cgaggaagaa cttacaaagc   1800

caagactctt gtgggctctt tattttaata tgagagattc ctcgggaatc agcagaagct   1860

cgtataatgg cttgccttcc aatgtttatg tctgctctgg gcctgactgt ggcctgggaa   1920

atgagcatgc tgtcaagcaa gctgaaacac ttttccagga gatctttcca actgaagaat   1980

tctgccctcc acctccaaat ccagaagaca ttatctttga tggtgatgat aagcagccag   2040

aggctcctgg aaccaataat gtagtaatgg ccaaactaga atcctctgag gaaagcaaaa   2100

acctagaaag cccagagaag caccttcaaa attagaaaag agcaatctcg aaatgctgtt   2160

ttggacctcc ttcatggcat cagaattttc tcatttaaag gacagtttcc catatgagta   2220

attagaagtg gttatatatg atgaatgcta tgcagatgtt gtctttaact ctcagacatt   2280

cagcattgaa tatctttgtt aacctatcaa tgagtgattt attgattatt gaacattttg   2340

tttagaatgg gctatatgac ccagaatctt aaaacagagt tagctttatt ttagtattgg   2400

gtatatatgt aagggttcca tattagcaac tcagcttaaa ggtaatgtat ttgctaatga   2460

tcttcagatt ttatctttgt ctacagaaca attagtaata cccaagtaat attttaatta   2520

cttttgcagc tgttacagtt gctgcggcct gttcgaatag tgaaacatac acaaatggta   2580

aattatgtgg atcttttgca tataatataa atgtatagac atggtggtag gaatagcaac   2640

taatacaaat gccaatatga taataaaata catttgtcta taatcgttta aagattagct   2700

ttgcatgatc ctttatgcac tgtgaaggtc tgaagtttat aatactcact tgacccttgt   2760

aactgatgag gcaatgatgc caccacagta ttctaattta caaaaagaat tggagttcaa   2820

ttagtggttg taaagctcat tttggggagg ttgattgcaa aggaaatttg aaagataaga   2880

tttattctta tttaatactt cagaaaattt ctgcagagcc ctgccctggc acttaaaata   2940

gcttccaata agtaacttag accaaaagga aaaatgaagt gccccaggag aagatacttc   3000

agaagggctg ttctgaaatt cctaaggagg aattcttagg aattcctaag gagaaacaga   3060

gtgaggcctt tttaacctga gattacagat acttataaaa ccctctataa atagattacc   3120

caaggttttt cagtgagaat gaaacatacc accttgttgg ctctaccact ttaattaata   3180

tcactataac ataactgata ggaatgaatc aaaggaggat ttaccatgcc ctttcggttg   3240

tgtcccactt aacaaattgt gaagtaacaa ttttctgtaa tctctcttgc ctcttagctg   3300

ttatccagag tatagaaact ttttttctcc cagagccacc caacgtcata aaactggtag   3360

tactctaatg gtgaaaacct gtggagctgt cagaagacat gaacttgctt ttcctctagt   3420

ccagtttcca ttcttcagtc agagtatgat gatccctgtg acagtttttg ctctgaaata   3480

gtatttatca tgtgtttggt acctagtatt atgctttctc atgacagttt ctcaacaatc   3540

ctgtgaggca aattcgcatg taccctctgt attagtgtgt tctcatgctg ttgataaaga   3600

cacacctgag atggtaattt gtaaagaaaa aggtttaatg gactcacagt tccatgtggc   3660

tggggaggcc tcacaatcat ggtggaaggt gaaaggcacg tcttacatgg cggtggacaa   3720

gagagaatga gaactaagtg aaaagggaaa cccttttaaa accatcagat atcgtgagac   3780

ttatttacta ccatgagaac agtatggggg aaacaactcc atgattcagt tatctcccac   3840

caggttcctc ccacaacacg tgggaattat aggagctaca attcaagatg agatttgagt   3900

gggaacacag ccaaaccata tcaccttcaa agaagaaata agagaattat tagtaatttg   3960

ctcagaatct ggtatgtgga agagccaaca tggggaccca gccttttgtg attctaaaac   4020

ctttgatctt tctactaaca ttcactgtta gagagtgtag gcgctgcagg agaaagagaa   4080

agtgcccacg aaaattagtc tagcattgcc gggggtaaaa agcacacact ggtcctgcag   4140

cttattgaat cagagaaatg tgaagataag atgaactaaa caaacatatt ttagagcatg   4200

gatctcgaag cagaatttgg ctaaatttta acaaaatgtt cttcagtaac acatctcatg   4260

atctgaagat tgtgttacaa aaaatattat caggccaaaa tttgttcgga atacactaat   4320

ttttgctcct ctatatgtga ggaaaatgag actagacaga tttaagtaat tgacaactta   4380

cttaaagtag caaagtcatg gattgtattg acttttaaaa atatagtaaa agtcatattt   4440

aaactttatc ctaaagttta aatctaacag aacaactgaa atacttgaaa tagacctata   4500

aaatagtaat taaaatgaga aatacataag atgataaata aaatgaaggt gaaggtattc   4560

cagatctacc gaaaagattt tcagtatcac agattattca taagaaattg agaaaaggaa   4620

caatcagaag ttgcaaaaga tggtatagcc gaatataatg gaaataggaa aaattagtcg   4680

aaaataaagg ttgatttaga aatgaagaaa atgaatatat ttcttaatac aaaataagtg   4740

ggaaatgaga agttatacca ataaaaagca tttaaaaatt taggggatat tgtaacccag   4800

tataattttc tgacaggttg gactttgacc ctaatggact tactggtgaa ctttttcaaa   4860

tgtttaaata atgtctatcc atgtatcatg aaggacagta tgcttcaaat tgtcttttga   4920

ggcagacatg ttctcagtac taaaagacat ttttagaagg attttattct caacagatgc   4980

aaaatgcaaa ataaaatatt ggcaaacaat acagcaacaa ataatttact atcactcagg   5040

attataaggc tggtgttaag cagaacagcc attaaatcag catcaaaaga acaaatagta   5100

aaatccaaag tattaattac agataacttt tcaaaaattc atcattcacc cttgatttaa   5160

ttatttctct ggcaatgatt taatagactt ctcggagtct gttaagtact taaaccaaga   5220

actaccatta ttcctactgg gaaaacataa acatttctca agtggaaagt aaacagtgtt   5280

ggcactattt ttatatatgg ttaaagagac ctgtcattgc aataaaagcc agcattcaca   5340

aaatgaggaa gataaggaaa gtagcataaa tattttctat taacatggct ttacaactgc   5400

taaaacttat agtataaaaa tgtactaaca aagactaatt caagaagttg caggatacac   5460

aatttttaaa aatctcattt ctacatctta gcagtgacaa actgcaattt aaaaagtgtg   5520

tttggttatt aatatatatg agacttttaa agaaagttat ataactacat agagataaat   5580

taagaaagat gcctaaatag aagcaagttt aaagagctat atttttaaac atgaacaaac   5640

tcccatggga gccatgccag tgtagtggaa aagtagtaca tggggagatg gggagttttt   5700

ttgaaaacca gaattacagt tctcatttca ctacttacca gttgtatact cttgggaaag   5760

tcactcctag tatctatttc accatctaca gaagagaaat acttcacaga attattgtgg   5820

ggattaagtt agataatgtg ttttaaaata taaagctaca tccaaagaaa tgccaatatg   5880

tgacattagt atgaaattta ctacagttcc atttaacatt ccaactggtt gctgtgtgga   5940

atatggcata attgtaataa attatttagg aaagcaagca aagatgtaag tttttttaat   6000

ttagggggaa aaaatgggag ccttgctctc caaatcctta aaacatgcta ttaagcaacc   6060

tttctgaata ttctgtggtg ccaagtagaa agtttaactg aaattaataa gccaatggaa   6120

agaaagaaat attaataact gctggtggaa agactagcta gatgtcagtg tggaaagatt   6180

agatccactt tacatgtgat attccaaatg aattaaaatg ttaagtataa aaagaaaaat   6240

actacaagtc tcacaccaat agtggtataa aggaacttca tggcaattgg caaggtagat   6300

caactaagag aaaaagtttt aaatgtgtag taaataggaa aaagacaaaa caagatggaa   6360

tttaaaagaa gctatttgca ttacacatgg atgcactcag tttttgtaaa actatatgca   6420

tatccataag ggtttgtact cttaggcaaa tttataaagc gatcgtgtat aaatgatata   6480

aaaaatcaat ttgaatggta ttcaaatttc ctaatattaa aaatgcaact ttgacttagt   6540

tcatgctatt gtattagcaa aactgtttta attgcatgtg tccttatagc agcagcattg   6600

tgtattagta gccttttaag agaactgtgt agaagactat aaaaagggct ttataactga   6660

tcttttgaca tactcacttt gagtggcata tgcccaggaa aatatttaaa agaaagaaaa   6720

gctatttgta caaagttttc tagcagttcc actcagataa ctttaagggg gaaaaaagcc   6780

caacgattgg aaatggttaa gtaaattttg gtgtattgct agtgctatca cagaatgtta   6840

tatagccatt caataatatt gatatatgtc aaattgtatg caaaaaagtg agattcaaaa   6900

atgttaataa gaacataaat tgtgtttact gatacatgtg aaaatttagg tctacattga   6960

aaagaatcag aagataacat gtaattcagt ttaacattag gggttcttta tttttcttct   7020

gttaaatatt gatgtatgca ataaaaaata aaagattaat tggtaaaaaa aaaaaaaaaa   7080

aa                                                                  7082


<210>  111
<211>  656
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Ala Asp Asn Leu Pro Thr Glu Phe Asp Val Val Ile Ile Gly Thr 
1               5                   10                  15


Gly Leu Pro Glu Ser Ile Leu Ala Ala Ala Cys Ser Arg Ser Gly Gln 
            20                  25                  30


Arg Val Leu His Ile Asp Ser Arg Ser Tyr Tyr Gly Gly Asn Trp Ala 
        35                  40                  45


Ser Phe Ser Phe Ser Gly Leu Leu Ser Trp Leu Lys Glu Tyr Gln Gln 
    50                  55                  60


Asn Asn Asp Ile Gly Glu Glu Ser Thr Val Val Trp Gln Asp Leu Ile 
65                  70                  75                  80


His Glu Thr Glu Glu Ala Ile Thr Leu Arg Lys Lys Asp Glu Thr Ile 
                85                  90                  95


Gln His Thr Glu Ala Phe Cys Tyr Ala Ser Gln Asp Met Glu Asp Asn 
            100                 105                 110


Val Glu Glu Ile Gly Ala Leu Gln Lys Asn Pro Ser Leu Gly Val Ser 
        115                 120                 125


Asn Thr Phe Thr Glu Val Leu Asp Ser Ala Leu Pro Glu Glu Ser Gln 
    130                 135                 140


Leu Ser Tyr Phe Asn Ser Asp Glu Met Pro Ala Lys His Thr Gln Lys 
145                 150                 155                 160


Ser Asp Thr Glu Ile Ser Leu Glu Val Thr Asp Val Glu Glu Ser Val 
                165                 170                 175


Glu Lys Glu Lys Tyr Cys Gly Asp Lys Thr Cys Met His Thr Val Ser 
            180                 185                 190


Asp Lys Asp Gly Asp Lys Asp Glu Ser Lys Ser Thr Val Glu Asp Lys 
        195                 200                 205


Ala Asp Glu Pro Ile Arg Asn Arg Ile Thr Tyr Ser Gln Ile Val Lys 
    210                 215                 220


Glu Gly Arg Arg Phe Asn Ile Asp Leu Val Ser Lys Leu Leu Tyr Ser 
225                 230                 235                 240


Gln Gly Leu Leu Ile Asp Leu Leu Ile Lys Ser Asp Val Ser Arg Tyr 
                245                 250                 255


Val Glu Phe Lys Asn Val Thr Arg Ile Leu Ala Phe Arg Glu Gly Lys 
            260                 265                 270


Val Glu Gln Val Pro Cys Ser Arg Ala Asp Val Phe Asn Ser Lys Glu 
        275                 280                 285


Leu Thr Met Val Glu Lys Arg Met Leu Met Lys Phe Leu Thr Phe Cys 
    290                 295                 300


Leu Glu Tyr Glu Gln His Pro Asp Glu Tyr Gln Ala Phe Arg Gln Cys 
305                 310                 315                 320


Ser Phe Ser Glu Tyr Leu Lys Thr Lys Lys Leu Thr Pro Asn Leu Gln 
                325                 330                 335


His Phe Val Leu His Ser Ile Ala Met Thr Ser Glu Ser Ser Cys Thr 
            340                 345                 350


Thr Ile Asp Gly Leu Asn Ala Thr Lys Asn Phe Leu Gln Cys Leu Gly 
        355                 360                 365


Arg Phe Gly Asn Thr Pro Phe Leu Phe Pro Leu Tyr Gly Gln Gly Glu 
    370                 375                 380


Ile Pro Gln Gly Phe Cys Arg Met Cys Ala Val Phe Gly Gly Ile Tyr 
385                 390                 395                 400


Cys Leu Arg His Lys Val Gln Cys Phe Val Val Asp Lys Glu Ser Gly 
                405                 410                 415


Arg Cys Lys Ala Ile Ile Asp His Phe Gly Gln Arg Ile Asn Ala Lys 
            420                 425                 430


Tyr Phe Ile Val Glu Asp Ser Tyr Leu Ser Glu Glu Thr Cys Ser Asn 
        435                 440                 445


Val Gln Tyr Lys Gln Ile Ser Arg Ala Val Leu Ile Thr Asp Gln Ser 
    450                 455                 460


Ile Leu Lys Thr Asp Leu Asp Gln Gln Thr Ser Ile Leu Ile Val Pro 
465                 470                 475                 480


Pro Ala Glu Pro Gly Ala Cys Ala Val Arg Val Thr Glu Leu Cys Ser 
                485                 490                 495


Ser Thr Met Thr Cys Met Lys Asp Thr Tyr Leu Val His Leu Thr Cys 
            500                 505                 510


Ser Ser Ser Lys Thr Ala Arg Glu Asp Leu Glu Ser Val Val Lys Lys 
        515                 520                 525


Leu Phe Thr Pro Tyr Thr Glu Thr Glu Ile Asn Glu Glu Glu Leu Thr 
    530                 535                 540


Lys Pro Arg Leu Leu Trp Ala Leu Tyr Phe Asn Met Arg Asp Ser Ser 
545                 550                 555                 560


Gly Ile Ser Arg Ser Ser Tyr Asn Gly Leu Pro Ser Asn Val Tyr Val 
                565                 570                 575


Cys Ser Gly Pro Asp Cys Gly Leu Gly Asn Glu His Ala Val Lys Gln 
            580                 585                 590


Ala Glu Thr Leu Phe Gln Glu Ile Phe Pro Thr Glu Glu Phe Cys Pro 
        595                 600                 605


Pro Pro Pro Asn Pro Glu Asp Ile Ile Phe Asp Gly Asp Asp Lys Gln 
    610                 615                 620


Pro Glu Ala Pro Gly Thr Asn Asn Val Val Met Ala Lys Leu Glu Ser 
625                 630                 635                 640


Ser Glu Glu Ser Lys Asn Leu Glu Ser Pro Glu Lys His Leu Gln Asn 
                645                 650                 655


<210>  112
<211>  2632
<212>  DNA
<213>  Homo sapiens

<400>  112
agaaatggcg gttggggcgg agcagggggc tggcgcggga agcggggctg tctggctcgg     60

ttacgccccc acctcgccag gaatctagga gtcggtttgt tttccgaacc catctccttc    120

cgctctcccg cccctgcagg ctgtgtgccg agcttggaag aaagtgtgac ccgttcgacg    180

gaacaaagga catgacagcc cggccccgtg cggccactgc ggagcgttag gaacattccc    240

taaaatggcg gccggcgcgt cggaacaggg cgggaggcgg cggcgcgtgg gggcgggacg    300

gggaggggcg cggccagccg ggcttctgct tccgcgaccc cggcggtgca gggcgggtgg    360

agtcgcggag tagtcctcat ggccgccccg ccggagcccg gtgagcccga ggagaggaag    420

tcccttaagc tcctaggatt tttagatgtt gaaaatactc cctgcgcccg gcattcaata    480

ttgtatggtt cattaggatc tgttgtggct ggctttggac attttttgtt cactagtaga    540

attagaagat catgtgatgt tggagtagga gggtttatct tggtgacttt gggatgctgg    600

tttcattgta ggtataatta tgcaaagcaa agaatccagg aaagaattgc cagagaagaa    660

attaaaaaga agatattata tgaaggtacc cacctcgatc ctgaaagaaa acacaacggc    720

agcagcagca attgaacaat cttgagcata gaagtcaatg taaacgaagt taagatcaac    780

cacataaaac atttcatgtg caataagctc tcaatcaagt aaataaagtt taagttgtag    840

tcattttttt cccacacttg tgtggaatga aaacttgcca gtttattctg gccctgtgtc    900

tactgccagg atagcattct tacgtgttac atatagtgga cttgtcatcc ttaaaatgtg    960

aacagaattt attggcagtg tggcaaagaa ttataaaaca tagtgtttaa tgtacttgga   1020

gtttccttgt agtagtaagt atagagtttg atgataagta aacgtccctt aacaaaaacc   1080

tcaaccttat tactatccca ttaaaaaaca gcaaatactt actgagttct tgtaagagct   1140

aatgtcattg taagatttaa aactaagggc ttttatcact ttgcaaatta ttttttaaat   1200

gcattcatca tttgacagtg ttctctcatt tcttaaaatg cgagtcatct tccaaaagag   1260

ttgtttttaa ctgccctaaa catttttggg gaagtatgca gggtttaaat ttttaagtat   1320

aattagttct gaattaaaat atgcacatgg aacttgtctg gcagactgat gcaatagtaa   1380

aacaactgca gaattactat taatgtaaac aatccatttg aaagtcaatc agctgctccc   1440

attaaaatat tatttaaaat acaataccca cagcatctaa ctaaatcctc aggatttatt   1500

ctccgggaga aattatccct ttctaggaaa atgaagttat ttctggtttt aattcataca   1560

atactttaag aaaatctgtt aaatataaca aaacacaagc tagatgctta agaaatgctt   1620

aaagaaatat tggggcgaag gtaacagcag tcaacaggat tgtggccatt actggtccta   1680

ttattttgat gtaccatgga aggcacagaa atcgagcaag gaagaaaata ttagttattt   1740

tgatctacat ctttttctaa agaaaagtgg agcttgcctc cagttcaatt cacaagagca   1800

ttttccctcc catgcccacc ttttcttgtg gctgtcgcta ggaaggatgc agaggctgtg   1860

tggtttacca aatgccttaa cttagcagtg aatgacaact gtcaaacaca tgttgaggga   1920

aaatttttac tgattcacaa aaaggaagac agtttgccca ctcttagtgg cacaaatcaa   1980

agctgcatgc actacattat ccaaattagt cgtaaccaaa tagttaaaaa attctgctgg   2040

gcacggtggc tcatacctgt aatcccagca ctttgggagg ccgaggcagt tggatcacct   2100

gaggttagga gtttgagacc agcctggcca acagggtgaa accctgtctc gtctaaaaat   2160

acaaaaatta gccgggcgtg gtggtgcatg cctgtagtcc caggtactca ggaggctgag   2220

gcaggagaat cacttgaacc cgaggtgggg caggcggagg ttgcagtaag ccaagatcgc   2280

gccattgcac tctagcctag gtgacagagt gagactccat ctcaaaaaaa aaaaaaaatt   2340

ccataggatg ttcaaccatg ttttcagagg ccgcactgca tgaatgcggg aaaatgttga   2400

tgatcactaa tcaataatct gatatttaac aaaatatgga caggccactt atgctcagtt   2460

ttaccttagt tattccttgg tatccacagg cccaagtccc tttaaataaa ataccctcat   2520

atttccatat aatctacata cattctccca tatactttaa atcatctcta gattacttat   2580

aatgtctaat acaaaataaa tgctatgtaa atgtaaaaaa aaaaaaaaaa aa           2632


<210>  113
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Ala Ala Pro Pro Glu Pro Gly Glu Pro Glu Glu Arg Lys Ser Leu 
1               5                   10                  15


Lys Leu Leu Gly Phe Leu Asp Val Glu Asn Thr Pro Cys Ala Arg His 
            20                  25                  30


Ser Ile Leu Tyr Gly Ser Leu Gly Ser Val Val Ala Gly Phe Gly His 
        35                  40                  45


Phe Leu Phe Thr Ser Arg Ile Arg Arg Ser Cys Asp Val Gly Val Gly 
    50                  55                  60


Gly Phe Ile Leu Val Thr Leu Gly Cys Trp Phe His Cys Arg Tyr Asn 
65                  70                  75                  80


Tyr Ala Lys Gln Arg Ile Gln Glu Arg Ile Ala Arg Glu Glu Ile Lys 
                85                  90                  95


Lys Lys Ile Leu Tyr Glu Gly Thr His Leu Asp Pro Glu Arg Lys His 
            100                 105                 110


Asn Gly Ser Ser Ser Asn 
        115


<210>  114
<211>  6789
<212>  DNA
<213>  Homo sapiens

<400>  114
ctcgcgccag gcgagtctcc gcgtctccct cgcgaactcg gtgaaaggaa ttggcgccgt     60

tcgacaccag gcggatccgc tctgcagcac gaacccatct ccagccgcag ccgcagccgc    120

cgcccgggcc gaggagcagc cgcagcagcc gccaccagtg gccgagtgag cggagccgag    180

tttgaggcag cgcctagcgg tgaatcgggg ccctcaccat gagttcctcg cctgttaatg    240

taaaaaagct gaaggtgtcg gagctgaaag aggagctcaa gaagcgacgc ctttctgaca    300

agggtctcaa ggccgagctc atggagcgac tccaggctgc gctggacgac gaggaggccg    360

ggggccgccc cgccatggag cccgggaacg gcagcctaga cctgggcggg gattccgctg    420

ggcgctcggg agcaggcctc gagcaggagg ccgcggccgg cggcgatgaa gaggaggagg    480

aagaggaaga ggaggaggaa ggaatctccg ctctggacgg cgaccagatg gagctaggag    540

aggagaacgg ggccgcgggg gcggccgact cgggcccgat ggaggaggag gaggccgcct    600

cggaagacga gaacggcgac gatcagggtt tccaggaagg ggaagatgag ctcggggacg    660

aagaggaagg cgcgggcgac gagaacgggc acggggagca gcagcctcaa ccgccggcga    720

cgcagcagca acagccccaa cagcagcgcg gggccgccaa ggaggccgcg gggaagagca    780

gcggccccac ctcgctgttc gcggtgacgg tggcgccgcc cggggcgagg cagggccagc    840

agcaggcggg aggggacggc aaaacagaac agaaaggcgg agataaaaag aggggtgtta    900

aaagaccacg agaagatcat ggccgtggat attttgagta cattgaagag aacaagtata    960

gcagagccaa atctcctcag ccacctgttg aagaagaaga tgaacacttc gatgacacag   1020

tggtttgtct tgatacttat aattgtgatc tacattttaa aatatcaaga gatcgtctca   1080

gtgcttcttc ccttacaatg gagagttttg cttttctttg ggctggagga agagcatcct   1140

atggtgtgtc aaaaggcaaa gtgtgttttg agatgaaggt tacagagaag atcccagtaa   1200

ggcatttata tacaaaagat attgacatac atgaagttcg tattggctgg tcactaacta   1260

caagtggaat gttacttggt gaagaagaat tttcttatgg gtattctcta aaaggaataa   1320

aaacatgcaa ctgtgagact gaagattatg gagaaaagtt tgatgaaaat gatgtgatta   1380

catgttttgc taactttgaa agtgatgaag tagaactctc gtatgctaag aatggacaag   1440

atcttggcgt tgccttcaaa atcagtaagg aagttcttgc tggacggcca ctgttcccgc   1500

atgttctctg ccacaactgt gcagttgaat ttaattttgg tcagaaggaa aagccatatt   1560

ttccaatacc tgaagagtat actttcatcc agaacgtccc cttagaggat cgagttagag   1620

gaccaaaggg gcctgaagag aagaaagatt gtgaagttgt gatgatgatt ggcttgccag   1680

gagctggaaa aactacctgg gttactaaac atgcagcaga aaatccaggg aaatataaca   1740

ttcttggcac aaatactatt atggataaga tgatggtggc aggttttaag aagcaaatgg   1800

cagatactgg aaaactgaac acactgttgc agagagcccc ccagtgtctt gggaaattta   1860

ttgagattgc tgcccgaaag aagcgaaatt ttattctgga tcagacaaat gtgtctgctg   1920

ctgcccagag gagaaaaatg tgcctgtttg caggcttcca gcgaaaagct gttgtagttt   1980

gcccaaaaga tgaagactat aagcaaagaa cacagaagaa agcagaagta gaggggaaag   2040

acctaccaga acatgcggtc ctcaaaatga aaggaaactt taccctccca gaggtagctg   2100

agtgctttga tgaaataacc tatgttgaac ttcagaagga agaagcccaa aaactcttgg   2160

agcaatataa ggaagaaagc aaaaaggctc ttccaccaga aaagaaacag aacactggct   2220

caaagaaaag caataaaaat aagagtggca agaaccagtt taacagaggt ggtggccata   2280

gaggacgtgg aggattcaat atgcgtggtg gaaatttcag aggaggagcc cctgggaatc   2340

gtggcggata taataggagg ggcaacatgc cacagagagg tggtggcggt ggaggaagtg   2400

gtggaatcgg ctatccatac cctcgtgccc ctgtttttcc tggccgtggt agttactcaa   2460

acagagggaa ctacaacaga ggtggaatgc ccaacagagg gaactacaac cagaacttca   2520

gaggacgagg aaacaatcgt ggctacaaaa atcaatctca gggctacaac cagtggcagc   2580

agggtcaatt ctggggtcag aagccatgga gtcagcatta tcaccaagga tattattgaa   2640

tacccaaata aaacgaactg atacatattt ctccaaaacc ttcacaagaa gtcgactgtt   2700

ttctttagta ggctaacttt ttaaacattc cacaagagga agtgcctgcg ggttcctttt   2760

ttagaagctt tgtgggttga ttttttttct tttctttttt gtacattttt aattgcagtt   2820

taaaagtgaa tcgtaagaga acctcagcat tgtgcacgat aagagaatgt gtcagtattt   2880

cagggttcta cattttatct gtaaaatgtg actttttttt ttttttatca caacagaagt   2940

aaaatgttgc tttgtacctg gtgtctttta ttaagaattt actcccccca tttctcacag   3000

agaataacag tcgggagtca ttgtcacaat ataatagaaa tgttagcaac cagattcatg   3060

taaggactaa gtggtcctca tgaattgcat taagactctg tactgctcat attacactcc   3120

atcctctctg tagtttgctg ggtagtggag ggggtaagct aaatcatagt ttctgacaat   3180

aactgggaag gttttttctt aaaataacaa tggaattggt ataattggga ttgaaaacta   3240

aaacttggaa ctaagataga gaagatggag tgtatgtaga agggctgtta aaaatgtaaa   3300

acttggttgc attatttgtg gaggctcaaa cttgtgaagg ttaataccat aatttttcca   3360

tttgttctgc attttgattc tgaaaagaaa gctggctttg cccatttctt attaaaaaaa   3420

cttgttgtaa atccagttgt ctaatgggat ctatatgaag ttagccatgt ctgtatgccc   3480

ttctcccaca aaatactgta taactagtgt gcttgtagta gttaactcca ccatctttgt   3540

aagctaatga aattgtgagt cacccattta tatcttaatt tttaatcatg tcagttcttg   3600

aatgggtatc tccttagcct gctgatttct ttttctttct aaagaaagtg ggtggagaaa   3660

ttaatttaga cgtttgtttg caataaaaag aattcatttt actcttgttt tgggattctc   3720

gccatcaagg ttcaaaatcc ctttatataa ctcccaagag gagaaattta ttaagtgtgt   3780

gctttctgga cagcttattc tttactctgc atagaacatt taggttttaa aaacttaaat   3840

gtatactgac aattgataca taattatgaa gtaaagttga attcttccct tcccctcccc   3900

cccagacaac ttttaacata tttaatgagg ggaaaaggta ctggctggga gaagttaaca   3960

ctgagtttat catctttaca gaatgctaat gctgtcctca actgattatt ttatatacat   4020

atatatgata catgaaactc tgggatcaga tgcttttaga agccatcatg caagccagtc   4080

attgatgtca ctgctacaca acactgctaa cttgactgta gctatgtaat aacattagat   4140

cccctaattg taattatatt gggtttgcac agaacacttt aatcttcccc tcaccaatgt   4200

gaagtgagga atcaggagtc aaactgtaga actaaaattt gacttcagtc tagcgtttcc   4260

ttggtgtttt taggttgctt tggtaagttt aggtttgcta tatttctgat tgcttagaat   4320

tttgttttag ccctttaaaa tcagatcata aatatgaatt catacttcta aggaattttc   4380

ttgctataag ctggagttta ggtgatgtat aggttcagtt gagacatttt tggaacaggc   4440

aaatccttag ttaacataag atatttaaca gttgaagata gtgtcatgga tttttatctt   4500

ttttagcaag taatgctaag aaccactggc ctgagctact actcttcagt atacattatt   4560

aggattgcat agacttacta gaggaacagt ttcaggtttt gatgctaatc agtgttgtgt   4620

cctaaagttg tcctttgtgc ctttaaaaag ttttggatat atcttctagt ttaaaattgc   4680

ttattaagga attcatttta taattgcagt gggaaagtaa tggtcaagta acactaggta   4740

gactatcatg cctgtttagc ccagagaatt tggggggaga gagaatagat aaaaatggca   4800

cccagaaaaa tgttaaaatc tttagtcaag actagaatta atacaattgt ctacacttgt   4860

atggcagaaa taaccttata aagtgtttaa ggaattcaga gaagggaatg taccaaataa   4920

gcaacaggga gaaaattagg taagaagtaa gatacgaacg agaaacctga tttattgctc   4980

atccttccct tgcctcccta atggcaagca aaactctgaa catctgaaaa ggatgtagtt   5040

ctggacaaat cctgactacc cagaggaaac tcactgtgag attgctgttg atttgaaggg   5100

tgctttcact aaggttatat tttaaagtag aataacacat gctgagtgta aactggcttt   5160

ggattggtca gctgcagtag tacaaaaaca gcatagaatt tgagaaaact aaaactgcta   5220

tgagatagct atgagaaaac taaaactgct atgagataga aatgatgtaa aattatgtgg   5280

aaagttttcc ctcatatact cacatacagc ctttgaaggg ctctggctct gaccggttga   5340

tggccttgag cgagatgaaa tcatgaaatt gagtcaaatc aatttgacat tgaaatgaca   5400

agaggaaact cttaaataca taaaaacaag ctctcatttg cctaggatag atactgtctt   5460

aaaaataaag actgaaccta gatgttctga gcactagcaa caaggtattt taacaagttt   5520

aaaggaattc tctgaaaaag ttataaaatt attctaggaa acataaccat aatagtgttt   5580

taagggactt tcacctgggg attttatatt catgaacaga gtgtattctg tatttaaaat   5640

gtctcatttg tgggaattgg atgacatgtt ttttgataaa tttattcaca atataaattg   5700

actttttatt ctaggaccat gtgaataatg ggttccattg cacaaataca aatattttaa   5760

tagcttctta ggcagtggtg tagacatctt ggatataaat aattgtagat cttgtatatt   5820

tgatttttaa aaaactagaa taaacagaga ggcataaaca tatcttagag tccaagtggt   5880

agtgtttagc attggatata ataaatggat gttttacaaa gtgtttccat aattctcttc   5940

ctatacataa atgtcttgtt ttcaaaagtg gatggaactt ggctgggtgt ggtggctcac   6000

gcctgtaatc ctagcacttt gggaggccaa ggcgggagga tcacttgagc tcaggagttt   6060

gagaccatcc tgggcaacat agtgagacct ggtctcttga aaaaaaaaaa gtggatggaa   6120

cttgtagcag agaattttat ctacttctca acctgcttca gaatacccat ttgagatgtt   6180

cccctggaaa gatgaacaca atactgcatc tgaagccatt tcttcccacc taacattctt   6240

aaaatgatta gagtctaaac tttgtcattc attcctaatt ctggagctct gaggttgagg   6300

tgttcagagt ttggtgaata attgggttta agttttaaca ttttagtaat aataaaagca   6360

aacacataca tgttaaggcc tgacaatagg ttgcaatacc catgcattgg gactcatacc   6420

cagcataaat ggtgagggac tgaacattag tgctttgagc aagaattggt taactacctg   6480

agatctctaa aacagtaatt tgaattacta atacataaac cacaagtctc ttcgaattgt   6540

taattgccta aatttaccct aaaacttagt taacgctgca gtgcctttat taaagctttt   6600

ttttgggggg gggtgtgggc acagctactc cataacttta aattttaaag catgaaggtg   6660

atctagctag tgttagtgct tgagttggta gttacatagg ctgctcttga atcgtcctgt   6720

tttctttgcc tagtattagc accacaggta catatttgta aaataagcat taaaagtact   6780

ttgtccagc                                                           6789


<210>  115
<211>  806
<212>  PRT
<213>  Homo sapiens

<400>  115

Met Ser Ser Ser Pro Val Asn Val Lys Lys Leu Lys Val Ser Glu Leu 
1               5                   10                  15


Lys Glu Glu Leu Lys Lys Arg Arg Leu Ser Asp Lys Gly Leu Lys Ala 
            20                  25                  30


Glu Leu Met Glu Arg Leu Gln Ala Ala Leu Asp Asp Glu Glu Ala Gly 
        35                  40                  45


Gly Arg Pro Ala Met Glu Pro Gly Asn Gly Ser Leu Asp Leu Gly Gly 
    50                  55                  60


Asp Ser Ala Gly Arg Ser Gly Ala Gly Leu Glu Gln Glu Ala Ala Ala 
65                  70                  75                  80


Gly Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ile 
                85                  90                  95


Ser Ala Leu Asp Gly Asp Gln Met Glu Leu Gly Glu Glu Asn Gly Ala 
            100                 105                 110


Ala Gly Ala Ala Asp Ser Gly Pro Met Glu Glu Glu Glu Ala Ala Ser 
        115                 120                 125


Glu Asp Glu Asn Gly Asp Asp Gln Gly Phe Gln Glu Gly Glu Asp Glu 
    130                 135                 140


Leu Gly Asp Glu Glu Glu Gly Ala Gly Asp Glu Asn Gly His Gly Glu 
145                 150                 155                 160


Gln Gln Pro Gln Pro Pro Ala Thr Gln Gln Gln Gln Pro Gln Gln Gln 
                165                 170                 175


Arg Gly Ala Ala Lys Glu Ala Ala Gly Lys Ser Ser Gly Pro Thr Ser 
            180                 185                 190


Leu Phe Ala Val Thr Val Ala Pro Pro Gly Ala Arg Gln Gly Gln Gln 
        195                 200                 205


Gln Ala Gly Gly Asp Gly Lys Thr Glu Gln Lys Gly Gly Asp Lys Lys 
    210                 215                 220


Arg Gly Val Lys Arg Pro Arg Glu Asp His Gly Arg Gly Tyr Phe Glu 
225                 230                 235                 240


Tyr Ile Glu Glu Asn Lys Tyr Ser Arg Ala Lys Ser Pro Gln Pro Pro 
                245                 250                 255


Val Glu Glu Glu Asp Glu His Phe Asp Asp Thr Val Val Cys Leu Asp 
            260                 265                 270


Thr Tyr Asn Cys Asp Leu His Phe Lys Ile Ser Arg Asp Arg Leu Ser 
        275                 280                 285


Ala Ser Ser Leu Thr Met Glu Ser Phe Ala Phe Leu Trp Ala Gly Gly 
    290                 295                 300


Arg Ala Ser Tyr Gly Val Ser Lys Gly Lys Val Cys Phe Glu Met Lys 
305                 310                 315                 320


Val Thr Glu Lys Ile Pro Val Arg His Leu Tyr Thr Lys Asp Ile Asp 
                325                 330                 335


Ile His Glu Val Arg Ile Gly Trp Ser Leu Thr Thr Ser Gly Met Leu 
            340                 345                 350


Leu Gly Glu Glu Glu Phe Ser Tyr Gly Tyr Ser Leu Lys Gly Ile Lys 
        355                 360                 365


Thr Cys Asn Cys Glu Thr Glu Asp Tyr Gly Glu Lys Phe Asp Glu Asn 
    370                 375                 380


Asp Val Ile Thr Cys Phe Ala Asn Phe Glu Ser Asp Glu Val Glu Leu 
385                 390                 395                 400


Ser Tyr Ala Lys Asn Gly Gln Asp Leu Gly Val Ala Phe Lys Ile Ser 
                405                 410                 415


Lys Glu Val Leu Ala Gly Arg Pro Leu Phe Pro His Val Leu Cys His 
            420                 425                 430


Asn Cys Ala Val Glu Phe Asn Phe Gly Gln Lys Glu Lys Pro Tyr Phe 
        435                 440                 445


Pro Ile Pro Glu Glu Tyr Thr Phe Ile Gln Asn Val Pro Leu Glu Asp 
    450                 455                 460


Arg Val Arg Gly Pro Lys Gly Pro Glu Glu Lys Lys Asp Cys Glu Val 
465                 470                 475                 480


Val Met Met Ile Gly Leu Pro Gly Ala Gly Lys Thr Thr Trp Val Thr 
                485                 490                 495


Lys His Ala Ala Glu Asn Pro Gly Lys Tyr Asn Ile Leu Gly Thr Asn 
            500                 505                 510


Thr Ile Met Asp Lys Met Met Val Ala Gly Phe Lys Lys Gln Met Ala 
        515                 520                 525


Asp Thr Gly Lys Leu Asn Thr Leu Leu Gln Arg Ala Pro Gln Cys Leu 
    530                 535                 540


Gly Lys Phe Ile Glu Ile Ala Ala Arg Lys Lys Arg Asn Phe Ile Leu 
545                 550                 555                 560


Asp Gln Thr Asn Val Ser Ala Ala Ala Gln Arg Arg Lys Met Cys Leu 
                565                 570                 575


Phe Ala Gly Phe Gln Arg Lys Ala Val Val Val Cys Pro Lys Asp Glu 
            580                 585                 590


Asp Tyr Lys Gln Arg Thr Gln Lys Lys Ala Glu Val Glu Gly Lys Asp 
        595                 600                 605


Leu Pro Glu His Ala Val Leu Lys Met Lys Gly Asn Phe Thr Leu Pro 
    610                 615                 620


Glu Val Ala Glu Cys Phe Asp Glu Ile Thr Tyr Val Glu Leu Gln Lys 
625                 630                 635                 640


Glu Glu Ala Gln Lys Leu Leu Glu Gln Tyr Lys Glu Glu Ser Lys Lys 
                645                 650                 655


Ala Leu Pro Pro Glu Lys Lys Gln Asn Thr Gly Ser Lys Lys Ser Asn 
            660                 665                 670


Lys Asn Lys Ser Gly Lys Asn Gln Phe Asn Arg Gly Gly Gly His Arg 
        675                 680                 685


Gly Arg Gly Gly Phe Asn Met Arg Gly Gly Asn Phe Arg Gly Gly Ala 
    690                 695                 700


Pro Gly Asn Arg Gly Gly Tyr Asn Arg Arg Gly Asn Met Pro Gln Arg 
705                 710                 715                 720


Gly Gly Gly Gly Gly Gly Ser Gly Gly Ile Gly Tyr Pro Tyr Pro Arg 
                725                 730                 735


Ala Pro Val Phe Pro Gly Arg Gly Ser Tyr Ser Asn Arg Gly Asn Tyr 
            740                 745                 750


Asn Arg Gly Gly Met Pro Asn Arg Gly Asn Tyr Asn Gln Asn Phe Arg 
        755                 760                 765


Gly Arg Gly Asn Asn Arg Gly Tyr Lys Asn Gln Ser Gln Gly Tyr Asn 
    770                 775                 780


Gln Trp Gln Gln Gly Gln Phe Trp Gly Gln Lys Pro Trp Ser Gln His 
785                 790                 795                 800


Tyr His Gln Gly Tyr Tyr 
                805


<210>  116
<211>  6846
<212>  DNA
<213>  Homo sapiens

<400>  116
ctcgcgccag gcgagtctcc gcgtctccct cgcgaactcg gtgaaaggaa ttggcgccgt     60

tcgacaccag gcggatccgc tctgcagcac gaacccatct ccagccgcag ccgcagccgc    120

cgcccgggcc gaggagcagc cgcagcagcc gccaccagtg gccgagtgag cggagccgag    180

tttgaggcag cgcctagcgg tgaatcgggg ccctcaccat gagttcctcg cctgttaatg    240

taaaaaagct gaaggtgtcg gagctgaaag aggagctcaa gaagcgacgc ctttctgaca    300

agggtctcaa ggccgagctc atggagcgac tccaggctgc gctggacgac gaggaggccg    360

ggggccgccc cgccatggag cccgggaacg gcagcctaga cctgggcggg gattccgctg    420

ggcgctcggg agcaggcctc gagcaggagg ccgcggccgg cggcgatgaa gaggaggagg    480

aagaggaaga ggaggaggaa ggaatctccg ctctggacgg cgaccagatg gagctaggag    540

aggagaacgg ggccgcgggg gcggccgact cgggcccgat ggaggaggag gaggccgcct    600

cggaagacga gaacggcgac gatcagggtt tccaggaagg ggaagatgag ctcggggacg    660

aagaggaagg cgcgggcgac gagaacgggc acggggagca gcagcctcaa ccgccggcga    720

cgcagcagca acagccccaa cagcagcgcg gggccgccaa ggaggccgcg gggaagagca    780

gcggccccac ctcgctgttc gcggtgacgg tggcgccgcc cggggcgagg cagggccagc    840

agcaggcggg aggtaagaag aaggcggaag gcggcggagg cggcggtcgc cccggggctc    900

cggcggcggg ggacggcaaa acagaacaga aaggcggaga taaaaagagg ggtgttaaaa    960

gaccacgaga agatcatggc cgtggatatt ttgagtacat tgaagagaac aagtatagca   1020

gagccaaatc tcctcagcca cctgttgaag aagaagatga acacttcgat gacacagtgg   1080

tttgtcttga tacttataat tgtgatctac attttaaaat atcaagagat cgtctcagtg   1140

cttcttccct tacaatggag agttttgctt ttctttgggc tggaggaaga gcatcctatg   1200

gtgtgtcaaa aggcaaagtg tgttttgaga tgaaggttac agagaagatc ccagtaaggc   1260

atttatatac aaaagatatt gacatacatg aagttcgtat tggctggtca ctaactacaa   1320

gtggaatgtt acttggtgaa gaagaatttt cttatgggta ttctctaaaa ggaataaaaa   1380

catgcaactg tgagactgaa gattatggag aaaagtttga tgaaaatgat gtgattacat   1440

gttttgctaa ctttgaaagt gatgaagtag aactctcgta tgctaagaat ggacaagatc   1500

ttggcgttgc cttcaaaatc agtaaggaag ttcttgctgg acggccactg ttcccgcatg   1560

ttctctgcca caactgtgca gttgaattta attttggtca gaaggaaaag ccatattttc   1620

caatacctga agagtatact ttcatccaga acgtcccctt agaggatcga gttagaggac   1680

caaaggggcc tgaagagaag aaagattgtg aagttgtgat gatgattggc ttgccaggag   1740

ctggaaaaac tacctgggtt actaaacatg cagcagaaaa tccagggaaa tataacattc   1800

ttggcacaaa tactattatg gataagatga tggtggcagg ttttaagaag caaatggcag   1860

atactggaaa actgaacaca ctgttgcaga gagcccccca gtgtcttggg aaatttattg   1920

agattgctgc ccgaaagaag cgaaatttta ttctggatca gacaaatgtg tctgctgctg   1980

cccagaggag aaaaatgtgc ctgtttgcag gcttccagcg aaaagctgtt gtagtttgcc   2040

caaaagatga agactataag caaagaacac agaagaaagc agaagtagag gggaaagacc   2100

taccagaaca tgcggtcctc aaaatgaaag gaaactttac cctcccagag gtagctgagt   2160

gctttgatga aataacctat gttgaacttc agaaggaaga agcccaaaaa ctcttggagc   2220

aatataagga agaaagcaaa aaggctcttc caccagaaaa gaaacagaac actggctcaa   2280

agaaaagcaa taaaaataag agtggcaaga accagtttaa cagaggtggt ggccatagag   2340

gacgtggagg attcaatatg cgtggtggaa atttcagagg aggagcccct gggaatcgtg   2400

gcggatataa taggaggggc aacatgccac agagaggtgg tggcggtgga ggaagtggtg   2460

gaatcggcta tccataccct cgtgcccctg tttttcctgg ccgtggtagt tactcaaaca   2520

gagggaacta caacagaggt ggaatgccca acagagggaa ctacaaccag aacttcagag   2580

gacgaggaaa caatcgtggc tacaaaaatc aatctcaggg ctacaaccag tggcagcagg   2640

gtcaattctg gggtcagaag ccatggagtc agcattatca ccaaggatat tattgaatac   2700

ccaaataaaa cgaactgata catatttctc caaaaccttc acaagaagtc gactgttttc   2760

tttagtaggc taacttttta aacattccac aagaggaagt gcctgcgggt tcctttttta   2820

gaagctttgt gggttgattt tttttctttt cttttttgta catttttaat tgcagtttaa   2880

aagtgaatcg taagagaacc tcagcattgt gcacgataag agaatgtgtc agtatttcag   2940

ggttctacat tttatctgta aaatgtgact tttttttttt tttatcacaa cagaagtaaa   3000

atgttgcttt gtacctggtg tcttttatta agaatttact ccccccattt ctcacagaga   3060

ataacagtcg ggagtcattg tcacaatata atagaaatgt tagcaaccag attcatgtaa   3120

ggactaagtg gtcctcatga attgcattaa gactctgtac tgctcatatt acactccatc   3180

ctctctgtag tttgctgggt agtggagggg gtaagctaaa tcatagtttc tgacaataac   3240

tgggaaggtt ttttcttaaa ataacaatgg aattggtata attgggattg aaaactaaaa   3300

cttggaacta agatagagaa gatggagtgt atgtagaagg gctgttaaaa atgtaaaact   3360

tggttgcatt atttgtggag gctcaaactt gtgaaggtta ataccataat ttttccattt   3420

gttctgcatt ttgattctga aaagaaagct ggctttgccc atttcttatt aaaaaaactt   3480

gttgtaaatc cagttgtcta atgggatcta tatgaagtta gccatgtctg tatgcccttc   3540

tcccacaaaa tactgtataa ctagtgtgct tgtagtagtt aactccacca tctttgtaag   3600

ctaatgaaat tgtgagtcac ccatttatat cttaattttt aatcatgtca gttcttgaat   3660

gggtatctcc ttagcctgct gatttctttt tctttctaaa gaaagtgggt ggagaaatta   3720

atttagacgt ttgtttgcaa taaaaagaat tcattttact cttgttttgg gattctcgcc   3780

atcaaggttc aaaatccctt tatataactc ccaagaggag aaatttatta agtgtgtgct   3840

ttctggacag cttattcttt actctgcata gaacatttag gttttaaaaa cttaaatgta   3900

tactgacaat tgatacataa ttatgaagta aagttgaatt cttcccttcc cctccccccc   3960

agacaacttt taacatattt aatgagggga aaaggtactg gctgggagaa gttaacactg   4020

agtttatcat ctttacagaa tgctaatgct gtcctcaact gattatttta tatacatata   4080

tatgatacat gaaactctgg gatcagatgc ttttagaagc catcatgcaa gccagtcatt   4140

gatgtcactg ctacacaaca ctgctaactt gactgtagct atgtaataac attagatccc   4200

ctaattgtaa ttatattggg tttgcacaga acactttaat cttcccctca ccaatgtgaa   4260

gtgaggaatc aggagtcaaa ctgtagaact aaaatttgac ttcagtctag cgtttccttg   4320

gtgtttttag gttgctttgg taagtttagg tttgctatat ttctgattgc ttagaatttt   4380

gttttagccc tttaaaatca gatcataaat atgaattcat acttctaagg aattttcttg   4440

ctataagctg gagtttaggt gatgtatagg ttcagttgag acatttttgg aacaggcaaa   4500

tccttagtta acataagata tttaacagtt gaagatagtg tcatggattt ttatcttttt   4560

tagcaagtaa tgctaagaac cactggcctg agctactact cttcagtata cattattagg   4620

attgcataga cttactagag gaacagtttc aggttttgat gctaatcagt gttgtgtcct   4680

aaagttgtcc tttgtgcctt taaaaagttt tggatatatc ttctagttta aaattgctta   4740

ttaaggaatt cattttataa ttgcagtggg aaagtaatgg tcaagtaaca ctaggtagac   4800

tatcatgcct gtttagccca gagaatttgg ggggagagag aatagataaa aatggcaccc   4860

agaaaaatgt taaaatcttt agtcaagact agaattaata caattgtcta cacttgtatg   4920

gcagaaataa ccttataaag tgtttaagga attcagagaa gggaatgtac caaataagca   4980

acagggagaa aattaggtaa gaagtaagat acgaacgaga aacctgattt attgctcatc   5040

cttcccttgc ctccctaatg gcaagcaaaa ctctgaacat ctgaaaagga tgtagttctg   5100

gacaaatcct gactacccag aggaaactca ctgtgagatt gctgttgatt tgaagggtgc   5160

tttcactaag gttatatttt aaagtagaat aacacatgct gagtgtaaac tggctttgga   5220

ttggtcagct gcagtagtac aaaaacagca tagaatttga gaaaactaaa actgctatga   5280

gatagctatg agaaaactaa aactgctatg agatagaaat gatgtaaaat tatgtggaaa   5340

gttttccctc atatactcac atacagcctt tgaagggctc tggctctgac cggttgatgg   5400

ccttgagcga gatgaaatca tgaaattgag tcaaatcaat ttgacattga aatgacaaga   5460

ggaaactctt aaatacataa aaacaagctc tcatttgcct aggatagata ctgtcttaaa   5520

aataaagact gaacctagat gttctgagca ctagcaacaa ggtattttaa caagtttaaa   5580

ggaattctct gaaaaagtta taaaattatt ctaggaaaca taaccataat agtgttttaa   5640

gggactttca cctggggatt ttatattcat gaacagagtg tattctgtat ttaaaatgtc   5700

tcatttgtgg gaattggatg acatgttttt tgataaattt attcacaata taaattgact   5760

ttttattcta ggaccatgtg aataatgggt tccattgcac aaatacaaat attttaatag   5820

cttcttaggc agtggtgtag acatcttgga tataaataat tgtagatctt gtatatttga   5880

tttttaaaaa actagaataa acagagaggc ataaacatat cttagagtcc aagtggtagt   5940

gtttagcatt ggatataata aatggatgtt ttacaaagtg tttccataat tctcttccta   6000

tacataaatg tcttgttttc aaaagtggat ggaacttggc tgggtgtggt ggctcacgcc   6060

tgtaatccta gcactttggg aggccaaggc gggaggatca cttgagctca ggagtttgag   6120

accatcctgg gcaacatagt gagacctggt ctcttgaaaa aaaaaaagtg gatggaactt   6180

gtagcagaga attttatcta cttctcaacc tgcttcagaa tacccatttg agatgttccc   6240

ctggaaagat gaacacaata ctgcatctga agccatttct tcccacctaa cattcttaaa   6300

atgattagag tctaaacttt gtcattcatt cctaattctg gagctctgag gttgaggtgt   6360

tcagagtttg gtgaataatt gggtttaagt tttaacattt tagtaataat aaaagcaaac   6420

acatacatgt taaggcctga caataggttg caatacccat gcattgggac tcatacccag   6480

cataaatggt gagggactga acattagtgc tttgagcaag aattggttaa ctacctgaga   6540

tctctaaaac agtaatttga attactaata cataaaccac aagtctcttc gaattgttaa   6600

ttgcctaaat ttaccctaaa acttagttaa cgctgcagtg cctttattaa agcttttttt   6660

tggggggggg tgtgggcaca gctactccat aactttaaat tttaaagcat gaaggtgatc   6720

tagctagtgt tagtgcttga gttggtagtt acataggctg ctcttgaatc gtcctgtttt   6780

ctttgcctag tattagcacc acaggtacat atttgtaaaa taagcattaa aagtactttg   6840

tccagc                                                              6846


<210>  117
<211>  825
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Ser Ser Ser Pro Val Asn Val Lys Lys Leu Lys Val Ser Glu Leu 
1               5                   10                  15


Lys Glu Glu Leu Lys Lys Arg Arg Leu Ser Asp Lys Gly Leu Lys Ala 
            20                  25                  30


Glu Leu Met Glu Arg Leu Gln Ala Ala Leu Asp Asp Glu Glu Ala Gly 
        35                  40                  45


Gly Arg Pro Ala Met Glu Pro Gly Asn Gly Ser Leu Asp Leu Gly Gly 
    50                  55                  60


Asp Ser Ala Gly Arg Ser Gly Ala Gly Leu Glu Gln Glu Ala Ala Ala 
65                  70                  75                  80


Gly Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ile 
                85                  90                  95


Ser Ala Leu Asp Gly Asp Gln Met Glu Leu Gly Glu Glu Asn Gly Ala 
            100                 105                 110


Ala Gly Ala Ala Asp Ser Gly Pro Met Glu Glu Glu Glu Ala Ala Ser 
        115                 120                 125


Glu Asp Glu Asn Gly Asp Asp Gln Gly Phe Gln Glu Gly Glu Asp Glu 
    130                 135                 140


Leu Gly Asp Glu Glu Glu Gly Ala Gly Asp Glu Asn Gly His Gly Glu 
145                 150                 155                 160


Gln Gln Pro Gln Pro Pro Ala Thr Gln Gln Gln Gln Pro Gln Gln Gln 
                165                 170                 175


Arg Gly Ala Ala Lys Glu Ala Ala Gly Lys Ser Ser Gly Pro Thr Ser 
            180                 185                 190


Leu Phe Ala Val Thr Val Ala Pro Pro Gly Ala Arg Gln Gly Gln Gln 
        195                 200                 205


Gln Ala Gly Gly Lys Lys Lys Ala Glu Gly Gly Gly Gly Gly Gly Arg 
    210                 215                 220


Pro Gly Ala Pro Ala Ala Gly Asp Gly Lys Thr Glu Gln Lys Gly Gly 
225                 230                 235                 240


Asp Lys Lys Arg Gly Val Lys Arg Pro Arg Glu Asp His Gly Arg Gly 
                245                 250                 255


Tyr Phe Glu Tyr Ile Glu Glu Asn Lys Tyr Ser Arg Ala Lys Ser Pro 
            260                 265                 270


Gln Pro Pro Val Glu Glu Glu Asp Glu His Phe Asp Asp Thr Val Val 
        275                 280                 285


Cys Leu Asp Thr Tyr Asn Cys Asp Leu His Phe Lys Ile Ser Arg Asp 
    290                 295                 300


Arg Leu Ser Ala Ser Ser Leu Thr Met Glu Ser Phe Ala Phe Leu Trp 
305                 310                 315                 320


Ala Gly Gly Arg Ala Ser Tyr Gly Val Ser Lys Gly Lys Val Cys Phe 
                325                 330                 335


Glu Met Lys Val Thr Glu Lys Ile Pro Val Arg His Leu Tyr Thr Lys 
            340                 345                 350


Asp Ile Asp Ile His Glu Val Arg Ile Gly Trp Ser Leu Thr Thr Ser 
        355                 360                 365


Gly Met Leu Leu Gly Glu Glu Glu Phe Ser Tyr Gly Tyr Ser Leu Lys 
    370                 375                 380


Gly Ile Lys Thr Cys Asn Cys Glu Thr Glu Asp Tyr Gly Glu Lys Phe 
385                 390                 395                 400


Asp Glu Asn Asp Val Ile Thr Cys Phe Ala Asn Phe Glu Ser Asp Glu 
                405                 410                 415


Val Glu Leu Ser Tyr Ala Lys Asn Gly Gln Asp Leu Gly Val Ala Phe 
            420                 425                 430


Lys Ile Ser Lys Glu Val Leu Ala Gly Arg Pro Leu Phe Pro His Val 
        435                 440                 445


Leu Cys His Asn Cys Ala Val Glu Phe Asn Phe Gly Gln Lys Glu Lys 
    450                 455                 460


Pro Tyr Phe Pro Ile Pro Glu Glu Tyr Thr Phe Ile Gln Asn Val Pro 
465                 470                 475                 480


Leu Glu Asp Arg Val Arg Gly Pro Lys Gly Pro Glu Glu Lys Lys Asp 
                485                 490                 495


Cys Glu Val Val Met Met Ile Gly Leu Pro Gly Ala Gly Lys Thr Thr 
            500                 505                 510


Trp Val Thr Lys His Ala Ala Glu Asn Pro Gly Lys Tyr Asn Ile Leu 
        515                 520                 525


Gly Thr Asn Thr Ile Met Asp Lys Met Met Val Ala Gly Phe Lys Lys 
    530                 535                 540


Gln Met Ala Asp Thr Gly Lys Leu Asn Thr Leu Leu Gln Arg Ala Pro 
545                 550                 555                 560


Gln Cys Leu Gly Lys Phe Ile Glu Ile Ala Ala Arg Lys Lys Arg Asn 
                565                 570                 575


Phe Ile Leu Asp Gln Thr Asn Val Ser Ala Ala Ala Gln Arg Arg Lys 
            580                 585                 590


Met Cys Leu Phe Ala Gly Phe Gln Arg Lys Ala Val Val Val Cys Pro 
        595                 600                 605


Lys Asp Glu Asp Tyr Lys Gln Arg Thr Gln Lys Lys Ala Glu Val Glu 
    610                 615                 620


Gly Lys Asp Leu Pro Glu His Ala Val Leu Lys Met Lys Gly Asn Phe 
625                 630                 635                 640


Thr Leu Pro Glu Val Ala Glu Cys Phe Asp Glu Ile Thr Tyr Val Glu 
                645                 650                 655


Leu Gln Lys Glu Glu Ala Gln Lys Leu Leu Glu Gln Tyr Lys Glu Glu 
            660                 665                 670


Ser Lys Lys Ala Leu Pro Pro Glu Lys Lys Gln Asn Thr Gly Ser Lys 
        675                 680                 685


Lys Ser Asn Lys Asn Lys Ser Gly Lys Asn Gln Phe Asn Arg Gly Gly 
    690                 695                 700


Gly His Arg Gly Arg Gly Gly Phe Asn Met Arg Gly Gly Asn Phe Arg 
705                 710                 715                 720


Gly Gly Ala Pro Gly Asn Arg Gly Gly Tyr Asn Arg Arg Gly Asn Met 
                725                 730                 735


Pro Gln Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Ile Gly Tyr Pro 
            740                 745                 750


Tyr Pro Arg Ala Pro Val Phe Pro Gly Arg Gly Ser Tyr Ser Asn Arg 
        755                 760                 765


Gly Asn Tyr Asn Arg Gly Gly Met Pro Asn Arg Gly Asn Tyr Asn Gln 
    770                 775                 780


Asn Phe Arg Gly Arg Gly Asn Asn Arg Gly Tyr Lys Asn Gln Ser Gln 
785                 790                 795                 800


Gly Tyr Asn Gln Trp Gln Gln Gly Gln Phe Trp Gly Gln Lys Pro Trp 
                805                 810                 815


Ser Gln His Tyr His Gln Gly Tyr Tyr 
            820                 825


<210>  118
<211>  8526
<212>  DNA
<213>  Homo sapiens

<400>  118
tggaagtatg cgagacttaa gagctcaagt gactagtggt ctcctgccat ttccagaagt     60

gactcttcaa gcccttggag aagacgaaat aacattagaa tctgtgcttc gtggaaagtt    120

tgctgcaggg aaaaatggac ttgcttgctt ggcttgtggt ccacaacttg aggtagtaaa    180

ctctataaca ggagagcgat tgtctgctta cagattcagt ggagtcaatg aacagcctcc    240

tgtagtttta gctgtgaaag aattctcttg gcagaagaga actggattat taataggatt    300

ggaagaaaca gaagggagtg ttctctgtct ttatgacctt ggaatatcaa aagtagttaa    360

agcagttgtt cttcctggaa gggtaacagc tattgaacct ataattaatc atggaggagc    420

cagtgcaagc actcagcatt tacatccaag tctgcgatgg ctttttggag tggcagctgt    480

ggtcactgat gttggacaga tccttcttgt tgacctatgt ttggatgact tgtcatgcaa    540

tcaaaatgaa gttgaagcat cagatcttga agttctaact ggtatcccag ctgaagtacc    600

acacattaga gaaagtgtaa tgagacaagg gcgccatctg tgtttccagt tagtaagtcc    660

aacaggaaca gctgtttcaa ctcttagtta cataagcagg acaaatcagc ttgctgtagg    720

tttttctgat ggctatctag cactttggaa catgaaaagc atgaaaagag aatattacat    780

acaattggaa agtggacaag ttcctgtata tgctgtcact tttcaagaac ctgagaatga    840

tcctcggaat tgctgttact tgtgggctgt tcagtctaca caagatagtg aaggggatgt    900

tttgagtttg catctgctgc agctggcctt tggtaataga aagtgtttgg catcaggaca    960

aatcttatat gaggggttag aatactgtga agaaagatac accctggacc tgacaggtgg   1020

catgttccct ttgaggggac agacgagtaa taccaaattg ttgggatgcc agagtataga   1080

gaaatttcga tctcatggtg acagggagga aggcgtgaat gaagctctat cgcctgacac   1140

tagtgtttca gtctttacct ggcaggtgaa tatatatgga cagggaaagc cttctgtata   1200

tttggggctt tttgatataa atcgttggta tcatgcacaa atgccagatt cgttaaggtc   1260

aggagaatat ctacataatt gctcttattt tgcactgtgg tcattggagt ctgttgtaag   1320

taggacttct ccacatggca tcttggatat attagtacat gagagaagtt taaatagagg   1380

agtccctcct tcatatccac ctcccgagca gttttttaat ccaagcactt ataattttga   1440

tgccacttgt ttgttaaact cgggagttgt tcatttaact tgtactggct ttcagaagga   1500

gactttgact tttttaaaga aatcaggtcc atcactcaat gaactcattc ctgatggtta   1560

taatcgatgt cttgtagctg gccttctttc cccaagattt gttgatgttc agccttccag   1620

tttaagccaa gaagaacagt tagaagctat attgtcagca gcaattcaga ctagttccct   1680

gggacttttg actggttata tccgaagatg gataacagaa gaacaaccaa attctgccac   1740

taatttgcgc tttgttcttg aatggacgtg gaataaagtg gttctcacaa aagaggaatt   1800

tgacagacta tgtgtgccat tatttgatgg ttcgtgtcat ttcatggatc cacaaactat   1860

acagtctatc cagcaatgct atttgcttct tagcaatctt aatatagtct tgagctgttt   1920

tgcatcagaa gcccgagaga tcactgagag aggactgata gacttaagca ataagtttgt   1980

ggtttcccac ctcatctgtc agtatgcaca agtggttctt tggttctctc attctgggct   2040

tttaccagaa ggcatagatg attctgtgca gttgtcaagg ttatgctaca actaccctgt   2100

aattcagaac tactacacca gtcgtcgaca gaagtttgag cgtttatcaa gagggaagtg   2160

gaatcccgat tgcttgatga ttgatggact ggtttctcag ttaggagagc gaattgagaa   2220

gttgtggaaa cgagatgaag gaggcacagg aaaatatcct cctgctagtc tgcatgcagt   2280

acttgatatg tacctattag acggcgttac tgaagcagcc aaacactcta ttaccattta   2340

tttgctactt gatattatgt attcctttcc caacaaaaca gacactccca ttgaatcttt   2400

cccaactgta tttgccattt cttggggcca agttaaactt attcaggggt tttggttgat   2460

agatcataat gactatgaga gtggtttgga tcttttgttt catccagcta ctgcaaaacc   2520

tttgtcatgg caacattcaa agattattca ggcattcatg agtcagggcg agcacagaca   2580

agccctcaga tatattcaga caatgaagcc aacagtgtcc agtggtaacg atgttatcct   2640

tcacctcact gttttgcttt ttaataggtg tatggttgaa gcctggaatt ttttgcggca   2700

acattgcaat aggttgaata tagaggagtt actgaagcac atgtatgaag tctgtcagga   2760

aatgggcttg atggaagatt tactgaagtt accatttaca gacactgagc aggaatgttt   2820

agtgaaattt ttgcagtcca gtgccagcgt tcagaatcat gaattccttt tagtgcacca   2880

tttgcagcgt gccaattatg tgcctgcctt gaagctgaac caaactctga agattaatgt   2940

tatgaatgat cgtgatcctc gtttgcggga gagatcactg gctcgaaatt ctatattaga   3000

ccagtatgga aaaatccttc ctagagtcca tcgaaaatta gccattgaac gagctaagcc   3060

ttatcatctg tcaacatcat cagtttttcg attagtttct agacccaaac cattatcagc   3120

agttccaaag caagttgtaa caggaactgt gttgacaaga tctgttttca tcaacaatgt   3180

gttatctaaa attggagaag tttgggcaag caaagaacct ataaatagca ccacaccttt   3240

caatagttct aaaatagaag aaccatctcc tatagtgtat tcgctcccag ctccagagct   3300

gcctgaggca ttttttggaa caccaatttc aaaagcatca caaaaaattt ctagactgct   3360

agatttggtt gttcagcctg tcccccggcc ttctcagtgt tcggagttta ttcagcaaag   3420

ctccatgaaa tctcctttgt acctagtatc ccgttcactg ccctcaagtt cgcaattaaa   3480

aggatcgcct caggccatct ccagggcttc agaattacat ttgcttgaaa ctcctcttgt   3540

agttaagaaa gctaaaagtt tggccatgtc agttactact tctggatttt ctgagttcac   3600

tcctcagtcc atcctgaggt ctactcttcg atcaacacct ttagcatctc cctctccatc   3660

acctggaagg tctcctcaac gacttaaaga aactagaatt tcatttgtgg aagaagatgt   3720

ccacccaaaa tggattcctg gggctgcaga tgatagcaaa ttagaagtat ttactacacc   3780

taaaaaatgt gcagttccag tggaaactga atggctgaag agcaaagata ggaccacatc   3840

ttttttcctg aacagccctg aaaaggagca tcaagaaatg gatgaggggt cacaaagttt   3900

agagaaactg gatgtgagca aaggaaacag cagtgtttca atcacatccg atgagactac   3960

cttagagtat caggatgcac cgtcaccgga agaccttgaa gagactgttt tcacggcctc   4020

taagcccaaa agctcttcca ctgcactaac tactaatgta actgaacaaa ctgaaaagga   4080

tggagataaa gatgtatttg catcagaagt aactccttca gacctacaga aacaaatggg   4140

caatttagaa gatgcagaaa caaaggatct cttagttgca gcagaggcat tttcagaatt   4200

gaatcactta agcccggttc aaggaactga agcttctctt tgtgcaccat cagtctatga   4260

agggaaaatc ttcacccaga agtccaaggt accagtgttg gacgaaggat taacatctgt   4320

tgaaacctac acccctgcaa ttagagcaaa tgacaataaa tctatggctg atgtccttgg   4380

tgatggtgga aactcctcgc tcactatctc tgaaggtcct attgtctctg agcgcaggct   4440

taaccaggaa gtagcgctga acttaaaaga agatcatgaa gtagaagttg gtgtactaaa   4500

agaaagtgtt gacttaccag aagaaaagct tccaatttct gacagccctc ctgatactca   4560

agaaattcat gtgattgaac aagaaaagct tgaagctcaa gattcaggag aagaggctag   4620

gaatctttca tttaatgagt tatatccctc tggaacactt aagcttcagt acaattttga   4680

tactattgac caacagtttt gtgacttagc tgataacaaa gacactgctg aatgtgacat   4740

tgctgaagta gatggggaac tttttgtggc tcaaagcaac tttaccttga tattggaagg   4800

tgaagaagga gaagttgagc caggtgattt tgcatcatct gatgtgttac ctaaagcagc   4860

taacacagca actgaagaaa aacttgtatg cagtggggaa aatgataatc atggacaaat   4920

tgcaaatttg ccatctgccg taactagtga ccaaaagtcc caaaaagtag acactttacc   4980

atatgtgcct gaacctatta aagtagcaat tgcagaaaat ttactagatg taattaaaga   5040

cacaagaagt aaagaaatta cttcagatac aatggaacag tccattcatg aaacaatacc   5100

tttagtgagc caaaacataa tgtgtcccac taaattggtc aaatctgcat ttaagactgc   5160

tcaggaaaca agcacaatga ctatgaatgt cagccaggtt gatgacgtgg tttcctccaa   5220

aactcgtacg agaggtcaac gtatccaaaa cgtgaatgtc aaatcagcac aacaggaagc   5280

atcagcagat gttgctactc ctaagatgcc agggcagtca gtcaggaaga aaactaggaa   5340

ggcaaaagaa atttctgaag cttctgaaaa catctattct gatgtcagag gactatctca   5400

gaaccagcaa atacctcaaa attctgttac gcctaggaga ggaaggagaa agaaagaagt   5460

taatcaggac atactagaaa acaccagttc tgtggaacaa gaattacaga tcactacagg   5520

tagggaatca aaaagattaa aatcatctca gctgttggaa ccagcagttg aagaaactac   5580

taaaaaagaa gttaaggttt catctgttac aaaaaggact cctagaagaa ttaaaagatc   5640

tgtagaaaat caggaaagtg ttgaaattat aaatgatcta aaagttagta cggtaacaag   5700

tcctagcaga atgatcagaa aattgagaag tactaattta gatgcttctg aaaatacagg   5760

aaataagcaa gatgataaat ccagtgacaa gcagctgcgt attaaacatg ttagaagggt   5820

cagagggaga gaagttagtc catcagatgt gagagaagac tccaaccttg agtcatctca   5880

gttgactgtt caagcagaat ttgatatgtc tgccatacct agaaaacgtg gtagaccaag   5940

aaaaatcaat ccatctgaag atgtaggatc taaggctgtt aaggaagaga gaagccccaa   6000

gaagaaagaa gctcccagca ttagaaggag atctacaaga aataccccag ctaaaagtga   6060

aaatgttgat gttggaaaac cagctttagg aaaatccatt ttagtgccaa acgaggaact   6120

ttcgatggtg atgagctcta agaaaaaact tacaaaaaag actgaaagtc aaagccaaaa   6180

acgttcattg cactcagtat cagaagaacg cacagatgaa atgacacata aagaaacaaa   6240

tgagcaggaa gaaagattgc tcgccacagc ttccttcact aaatcatccc gcagcagcag   6300

gactcggtct agcaaggcca tcttgttgcc ggacctttct gaaccaaaca atgagccttt   6360

attttctcca gcgtcagaag ttccaaggaa agcaaaagct aaaaaaatag aggttcctgc   6420

acagctgaaa gaattagttt cggatttatc ttctcagttt gtcatctcac ctcctgcttt   6480

aaggagcaga caaaaaaaca catccaataa gaacaagctt gaagatgaac tgaaagatga   6540

tgcacaatca gtagaaactc tgggaaagcc aaaagcgaaa cgaatcagga cgtcaaaaac   6600

aaaacaagca agcaaaaaca cagaaaaaga aagtgcttgg tcacctcctc ccatagaaat   6660

tcggctgatt tcccccttgg ctagcccagc tgacggagtc aagagcaaac caagaaaaac   6720

tacagaagtg acaggaacag gtcttggaag gaacagaaag aaactgtctt cctatccaaa   6780

gcaaatttta cgcagaaaaa tgctgtaatt tcttgggaag attttaatgt acacctattt   6840

gtaaagtcat cagaatagtg tggattatta aatatctagt ttggaagaaa ataatttata   6900

taaattattg taaattttta tgtaaacaga aggtcttcaa taagtaaagt aactccatat   6960

ggagtgattg tttcagtcca ggcaattttt ctattttata ttaagacttc atacatttat   7020

atatgtaaat atggcttatt aatggaatgt taaataaaat gtatacttca cagtcgtttg   7080

tgtcttggat ttttgaaagg gaggggatat ctgtttaaat agttttatat gctcattggt   7140

ctcattttct ctataattaa aatactagac cagtcttaaa atggggatga ttgaagtatt   7200

gatatttctt tttacagtta ctattttata atttatgcac tttgattctg tgattcagat   7260

ttctaatcag aaaatgtatt tttttgtttt tggctgttac tatgttaaaa ttgaattatg   7320

ggcatgtcat tttgccatct ttgtagtttc acaaattttg tgtaatctac ctcaaatgaa   7380

taatccaagt attggttaac tataatgttg gcatctctta ttcggcaagc ttaaaggctc   7440

tttaaagtct taattagtca aagactaatc caggttagat tgaccggttc actgctcact   7500

tgcaacctta tcaaagggtt tgacaaaggg aaatgtaaaa taaatctgtt tatggatatt   7560

gagtgcatct tgtatgtgcc taatattgat aggatgagat gtctgaacaa atttttataa   7620

tattgctgtg aaggagcttg ctattgaacc acagaaatcc cttaatattc aggttttaaa   7680

actggcaaat tctcacagga cctcaggcac agattattga ggttgggaga gagtgagtag   7740

atgtagaaaa ggagaaaaac aacacacgcc ctgttctcta cagtacaact gtgtgcaatt   7800

aagcaatggt acttgatgta ggctctaaca ctcatcaata aataagtgtt gtaaaataat   7860

ttataacagg taatcgatag tgtgtaatga atggactatt aataattgat tatctagaaa   7920

cgaactgctt tcgtgggctt ttaatatttt aatgtgaagc atatgcagtg tgctttctgc   7980

atttattttt ctaccaaata atacagataa tgagaaattg gtgaaaatgc ctacgcaaag   8040

tgttgacagt gtgaaagcag tgcgagtgcg gccttttagt caggttagtg atggatgtta   8100

cgctgccttg ttgaaaattt cactgacttt gattttatta cttttttaat gatagttatc   8160

aaacttgtat ttaagctgct tgtcatttat ggaatattga acttatttaa atgaacttgt   8220

taaatgaata aagagctaaa cataattcag taaacaattc ctttgcgcaa gtagcacaat   8280

aaacatggat gcaacgtatg tcaagttaat acttttttaa accaacgcaa tttggtgaat   8340

atagatgtgt ggtacctgtt tttaataagt gtactttttt tcccccctcc gtgaatgtag   8400

atcataagca aacaaattgc ctgttctaaa tgaactttac atatatttta aatgaatgta   8460

tgtacttacg tataaatgtc tttatatagc ttgaataaaa acactgctca ttaaaaaaaa   8520

aaaaaa                                                              8526


<210>  119
<211>  2266
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Arg Asp Leu Arg Ala Gln Val Thr Ser Gly Leu Leu Pro Phe Pro 
1               5                   10                  15


Glu Val Thr Leu Gln Ala Leu Gly Glu Asp Glu Ile Thr Leu Glu Ser 
            20                  25                  30


Val Leu Arg Gly Lys Phe Ala Ala Gly Lys Asn Gly Leu Ala Cys Leu 
        35                  40                  45


Ala Cys Gly Pro Gln Leu Glu Val Val Asn Ser Ile Thr Gly Glu Arg 
    50                  55                  60


Leu Ser Ala Tyr Arg Phe Ser Gly Val Asn Glu Gln Pro Pro Val Val 
65                  70                  75                  80


Leu Ala Val Lys Glu Phe Ser Trp Gln Lys Arg Thr Gly Leu Leu Ile 
                85                  90                  95


Gly Leu Glu Glu Thr Glu Gly Ser Val Leu Cys Leu Tyr Asp Leu Gly 
            100                 105                 110


Ile Ser Lys Val Val Lys Ala Val Val Leu Pro Gly Arg Val Thr Ala 
        115                 120                 125


Ile Glu Pro Ile Ile Asn His Gly Gly Ala Ser Ala Ser Thr Gln His 
    130                 135                 140


Leu His Pro Ser Leu Arg Trp Leu Phe Gly Val Ala Ala Val Val Thr 
145                 150                 155                 160


Asp Val Gly Gln Ile Leu Leu Val Asp Leu Cys Leu Asp Asp Leu Ser 
                165                 170                 175


Cys Asn Gln Asn Glu Val Glu Ala Ser Asp Leu Glu Val Leu Thr Gly 
            180                 185                 190


Ile Pro Ala Glu Val Pro His Ile Arg Glu Ser Val Met Arg Gln Gly 
        195                 200                 205


Arg His Leu Cys Phe Gln Leu Val Ser Pro Thr Gly Thr Ala Val Ser 
    210                 215                 220


Thr Leu Ser Tyr Ile Ser Arg Thr Asn Gln Leu Ala Val Gly Phe Ser 
225                 230                 235                 240


Asp Gly Tyr Leu Ala Leu Trp Asn Met Lys Ser Met Lys Arg Glu Tyr 
                245                 250                 255


Tyr Ile Gln Leu Glu Ser Gly Gln Val Pro Val Tyr Ala Val Thr Phe 
            260                 265                 270


Gln Glu Pro Glu Asn Asp Pro Arg Asn Cys Cys Tyr Leu Trp Ala Val 
        275                 280                 285


Gln Ser Thr Gln Asp Ser Glu Gly Asp Val Leu Ser Leu His Leu Leu 
    290                 295                 300


Gln Leu Ala Phe Gly Asn Arg Lys Cys Leu Ala Ser Gly Gln Ile Leu 
305                 310                 315                 320


Tyr Glu Gly Leu Glu Tyr Cys Glu Glu Arg Tyr Thr Leu Asp Leu Thr 
                325                 330                 335


Gly Gly Met Phe Pro Leu Arg Gly Gln Thr Ser Asn Thr Lys Leu Leu 
            340                 345                 350


Gly Cys Gln Ser Ile Glu Lys Phe Arg Ser His Gly Asp Arg Glu Glu 
        355                 360                 365


Gly Val Asn Glu Ala Leu Ser Pro Asp Thr Ser Val Ser Val Phe Thr 
    370                 375                 380


Trp Gln Val Asn Ile Tyr Gly Gln Gly Lys Pro Ser Val Tyr Leu Gly 
385                 390                 395                 400


Leu Phe Asp Ile Asn Arg Trp Tyr His Ala Gln Met Pro Asp Ser Leu 
                405                 410                 415


Arg Ser Gly Glu Tyr Leu His Asn Cys Ser Tyr Phe Ala Leu Trp Ser 
            420                 425                 430


Leu Glu Ser Val Val Ser Arg Thr Ser Pro His Gly Ile Leu Asp Ile 
        435                 440                 445


Leu Val His Glu Arg Ser Leu Asn Arg Gly Val Pro Pro Ser Tyr Pro 
    450                 455                 460


Pro Pro Glu Gln Phe Phe Asn Pro Ser Thr Tyr Asn Phe Asp Ala Thr 
465                 470                 475                 480


Cys Leu Leu Asn Ser Gly Val Val His Leu Thr Cys Thr Gly Phe Gln 
                485                 490                 495


Lys Glu Thr Leu Thr Phe Leu Lys Lys Ser Gly Pro Ser Leu Asn Glu 
            500                 505                 510


Leu Ile Pro Asp Gly Tyr Asn Arg Cys Leu Val Ala Gly Leu Leu Ser 
        515                 520                 525


Pro Arg Phe Val Asp Val Gln Pro Ser Ser Leu Ser Gln Glu Glu Gln 
    530                 535                 540


Leu Glu Ala Ile Leu Ser Ala Ala Ile Gln Thr Ser Ser Leu Gly Leu 
545                 550                 555                 560


Leu Thr Gly Tyr Ile Arg Arg Trp Ile Thr Glu Glu Gln Pro Asn Ser 
                565                 570                 575


Ala Thr Asn Leu Arg Phe Val Leu Glu Trp Thr Trp Asn Lys Val Val 
            580                 585                 590


Leu Thr Lys Glu Glu Phe Asp Arg Leu Cys Val Pro Leu Phe Asp Gly 
        595                 600                 605


Ser Cys His Phe Met Asp Pro Gln Thr Ile Gln Ser Ile Gln Gln Cys 
    610                 615                 620


Tyr Leu Leu Leu Ser Asn Leu Asn Ile Val Leu Ser Cys Phe Ala Ser 
625                 630                 635                 640


Glu Ala Arg Glu Ile Thr Glu Arg Gly Leu Ile Asp Leu Ser Asn Lys 
                645                 650                 655


Phe Val Val Ser His Leu Ile Cys Gln Tyr Ala Gln Val Val Leu Trp 
            660                 665                 670


Phe Ser His Ser Gly Leu Leu Pro Glu Gly Ile Asp Asp Ser Val Gln 
        675                 680                 685


Leu Ser Arg Leu Cys Tyr Asn Tyr Pro Val Ile Gln Asn Tyr Tyr Thr 
    690                 695                 700


Ser Arg Arg Gln Lys Phe Glu Arg Leu Ser Arg Gly Lys Trp Asn Pro 
705                 710                 715                 720


Asp Cys Leu Met Ile Asp Gly Leu Val Ser Gln Leu Gly Glu Arg Ile 
                725                 730                 735


Glu Lys Leu Trp Lys Arg Asp Glu Gly Gly Thr Gly Lys Tyr Pro Pro 
            740                 745                 750


Ala Ser Leu His Ala Val Leu Asp Met Tyr Leu Leu Asp Gly Val Thr 
        755                 760                 765


Glu Ala Ala Lys His Ser Ile Thr Ile Tyr Leu Leu Leu Asp Ile Met 
    770                 775                 780


Tyr Ser Phe Pro Asn Lys Thr Asp Thr Pro Ile Glu Ser Phe Pro Thr 
785                 790                 795                 800


Val Phe Ala Ile Ser Trp Gly Gln Val Lys Leu Ile Gln Gly Phe Trp 
                805                 810                 815


Leu Ile Asp His Asn Asp Tyr Glu Ser Gly Leu Asp Leu Leu Phe His 
            820                 825                 830


Pro Ala Thr Ala Lys Pro Leu Ser Trp Gln His Ser Lys Ile Ile Gln 
        835                 840                 845


Ala Phe Met Ser Gln Gly Glu His Arg Gln Ala Leu Arg Tyr Ile Gln 
    850                 855                 860


Thr Met Lys Pro Thr Val Ser Ser Gly Asn Asp Val Ile Leu His Leu 
865                 870                 875                 880


Thr Val Leu Leu Phe Asn Arg Cys Met Val Glu Ala Trp Asn Phe Leu 
                885                 890                 895


Arg Gln His Cys Asn Arg Leu Asn Ile Glu Glu Leu Leu Lys His Met 
            900                 905                 910


Tyr Glu Val Cys Gln Glu Met Gly Leu Met Glu Asp Leu Leu Lys Leu 
        915                 920                 925


Pro Phe Thr Asp Thr Glu Gln Glu Cys Leu Val Lys Phe Leu Gln Ser 
    930                 935                 940


Ser Ala Ser Val Gln Asn His Glu Phe Leu Leu Val His His Leu Gln 
945                 950                 955                 960


Arg Ala Asn Tyr Val Pro Ala Leu Lys Leu Asn Gln Thr Leu Lys Ile 
                965                 970                 975


Asn Val Met Asn Asp Arg Asp Pro Arg Leu Arg Glu Arg Ser Leu Ala 
            980                 985                 990


Arg Asn Ser Ile Leu Asp Gln Tyr Gly Lys Ile Leu Pro Arg Val His 
        995                 1000                1005


Arg Lys Leu Ala Ile Glu Arg Ala Lys Pro Tyr His Leu Ser Thr Ser 
    1010                1015                1020


Ser Val Phe Arg Leu Val Ser Arg Pro Lys Pro Leu Ser Ala Val Pro 
1025                1030                1035                1040


Lys Gln Val Val Thr Gly Thr Val Leu Thr Arg Ser Val Phe Ile Asn 
                1045                1050                1055


Asn Val Leu Ser Lys Ile Gly Glu Val Trp Ala Ser Lys Glu Pro Ile 
            1060                1065                1070


Asn Ser Thr Thr Pro Phe Asn Ser Ser Lys Ile Glu Glu Pro Ser Pro 
        1075                1080                1085


Ile Val Tyr Ser Leu Pro Ala Pro Glu Leu Pro Glu Ala Phe Phe Gly 
    1090                1095                1100


Thr Pro Ile Ser Lys Ala Ser Gln Lys Ile Ser Arg Leu Leu Asp Leu 
1105                1110                1115                1120


Val Val Gln Pro Val Pro Arg Pro Ser Gln Cys Ser Glu Phe Ile Gln 
                1125                1130                1135


Gln Ser Ser Met Lys Ser Pro Leu Tyr Leu Val Ser Arg Ser Leu Pro 
            1140                1145                1150


Ser Ser Ser Gln Leu Lys Gly Ser Pro Gln Ala Ile Ser Arg Ala Ser 
        1155                1160                1165


Glu Leu His Leu Leu Glu Thr Pro Leu Val Val Lys Lys Ala Lys Ser 
    1170                1175                1180


Leu Ala Met Ser Val Thr Thr Ser Gly Phe Ser Glu Phe Thr Pro Gln 
1185                1190                1195                1200


Ser Ile Leu Arg Ser Thr Leu Arg Ser Thr Pro Leu Ala Ser Pro Ser 
                1205                1210                1215


Pro Ser Pro Gly Arg Ser Pro Gln Arg Leu Lys Glu Thr Arg Ile Ser 
            1220                1225                1230


Phe Val Glu Glu Asp Val His Pro Lys Trp Ile Pro Gly Ala Ala Asp 
        1235                1240                1245


Asp Ser Lys Leu Glu Val Phe Thr Thr Pro Lys Lys Cys Ala Val Pro 
    1250                1255                1260


Val Glu Thr Glu Trp Leu Lys Ser Lys Asp Arg Thr Thr Ser Phe Phe 
1265                1270                1275                1280


Leu Asn Ser Pro Glu Lys Glu His Gln Glu Met Asp Glu Gly Ser Gln 
                1285                1290                1295


Ser Leu Glu Lys Leu Asp Val Ser Lys Gly Asn Ser Ser Val Ser Ile 
            1300                1305                1310


Thr Ser Asp Glu Thr Thr Leu Glu Tyr Gln Asp Ala Pro Ser Pro Glu 
        1315                1320                1325


Asp Leu Glu Glu Thr Val Phe Thr Ala Ser Lys Pro Lys Ser Ser Ser 
    1330                1335                1340


Thr Ala Leu Thr Thr Asn Val Thr Glu Gln Thr Glu Lys Asp Gly Asp 
1345                1350                1355                1360


Lys Asp Val Phe Ala Ser Glu Val Thr Pro Ser Asp Leu Gln Lys Gln 
                1365                1370                1375


Met Gly Asn Leu Glu Asp Ala Glu Thr Lys Asp Leu Leu Val Ala Ala 
            1380                1385                1390


Glu Ala Phe Ser Glu Leu Asn His Leu Ser Pro Val Gln Gly Thr Glu 
        1395                1400                1405


Ala Ser Leu Cys Ala Pro Ser Val Tyr Glu Gly Lys Ile Phe Thr Gln 
    1410                1415                1420


Lys Ser Lys Val Pro Val Leu Asp Glu Gly Leu Thr Ser Val Glu Thr 
1425                1430                1435                1440


Tyr Thr Pro Ala Ile Arg Ala Asn Asp Asn Lys Ser Met Ala Asp Val 
                1445                1450                1455


Leu Gly Asp Gly Gly Asn Ser Ser Leu Thr Ile Ser Glu Gly Pro Ile 
            1460                1465                1470


Val Ser Glu Arg Arg Leu Asn Gln Glu Val Ala Leu Asn Leu Lys Glu 
        1475                1480                1485


Asp His Glu Val Glu Val Gly Val Leu Lys Glu Ser Val Asp Leu Pro 
    1490                1495                1500


Glu Glu Lys Leu Pro Ile Ser Asp Ser Pro Pro Asp Thr Gln Glu Ile 
1505                1510                1515                1520


His Val Ile Glu Gln Glu Lys Leu Glu Ala Gln Asp Ser Gly Glu Glu 
                1525                1530                1535


Ala Arg Asn Leu Ser Phe Asn Glu Leu Tyr Pro Ser Gly Thr Leu Lys 
            1540                1545                1550


Leu Gln Tyr Asn Phe Asp Thr Ile Asp Gln Gln Phe Cys Asp Leu Ala 
        1555                1560                1565


Asp Asn Lys Asp Thr Ala Glu Cys Asp Ile Ala Glu Val Asp Gly Glu 
    1570                1575                1580


Leu Phe Val Ala Gln Ser Asn Phe Thr Leu Ile Leu Glu Gly Glu Glu 
1585                1590                1595                1600


Gly Glu Val Glu Pro Gly Asp Phe Ala Ser Ser Asp Val Leu Pro Lys 
                1605                1610                1615


Ala Ala Asn Thr Ala Thr Glu Glu Lys Leu Val Cys Ser Gly Glu Asn 
            1620                1625                1630


Asp Asn His Gly Gln Ile Ala Asn Leu Pro Ser Ala Val Thr Ser Asp 
        1635                1640                1645


Gln Lys Ser Gln Lys Val Asp Thr Leu Pro Tyr Val Pro Glu Pro Ile 
    1650                1655                1660


Lys Val Ala Ile Ala Glu Asn Leu Leu Asp Val Ile Lys Asp Thr Arg 
1665                1670                1675                1680


Ser Lys Glu Ile Thr Ser Asp Thr Met Glu Gln Ser Ile His Glu Thr 
                1685                1690                1695


Ile Pro Leu Val Ser Gln Asn Ile Met Cys Pro Thr Lys Leu Val Lys 
            1700                1705                1710


Ser Ala Phe Lys Thr Ala Gln Glu Thr Ser Thr Met Thr Met Asn Val 
        1715                1720                1725


Ser Gln Val Asp Asp Val Val Ser Ser Lys Thr Arg Thr Arg Gly Gln 
    1730                1735                1740


Arg Ile Gln Asn Val Asn Val Lys Ser Ala Gln Gln Glu Ala Ser Ala 
1745                1750                1755                1760


Asp Val Ala Thr Pro Lys Met Pro Gly Gln Ser Val Arg Lys Lys Thr 
                1765                1770                1775


Arg Lys Ala Lys Glu Ile Ser Glu Ala Ser Glu Asn Ile Tyr Ser Asp 
            1780                1785                1790


Val Arg Gly Leu Ser Gln Asn Gln Gln Ile Pro Gln Asn Ser Val Thr 
        1795                1800                1805


Pro Arg Arg Gly Arg Arg Lys Lys Glu Val Asn Gln Asp Ile Leu Glu 
    1810                1815                1820


Asn Thr Ser Ser Val Glu Gln Glu Leu Gln Ile Thr Thr Gly Arg Glu 
1825                1830                1835                1840


Ser Lys Arg Leu Lys Ser Ser Gln Leu Leu Glu Pro Ala Val Glu Glu 
                1845                1850                1855


Thr Thr Lys Lys Glu Val Lys Val Ser Ser Val Thr Lys Arg Thr Pro 
            1860                1865                1870


Arg Arg Ile Lys Arg Ser Val Glu Asn Gln Glu Ser Val Glu Ile Ile 
        1875                1880                1885


Asn Asp Leu Lys Val Ser Thr Val Thr Ser Pro Ser Arg Met Ile Arg 
    1890                1895                1900


Lys Leu Arg Ser Thr Asn Leu Asp Ala Ser Glu Asn Thr Gly Asn Lys 
1905                1910                1915                1920


Gln Asp Asp Lys Ser Ser Asp Lys Gln Leu Arg Ile Lys His Val Arg 
                1925                1930                1935


Arg Val Arg Gly Arg Glu Val Ser Pro Ser Asp Val Arg Glu Asp Ser 
            1940                1945                1950


Asn Leu Glu Ser Ser Gln Leu Thr Val Gln Ala Glu Phe Asp Met Ser 
        1955                1960                1965


Ala Ile Pro Arg Lys Arg Gly Arg Pro Arg Lys Ile Asn Pro Ser Glu 
    1970                1975                1980


Asp Val Gly Ser Lys Ala Val Lys Glu Glu Arg Ser Pro Lys Lys Lys 
1985                1990                1995                2000


Glu Ala Pro Ser Ile Arg Arg Arg Ser Thr Arg Asn Thr Pro Ala Lys 
                2005                2010                2015


Ser Glu Asn Val Asp Val Gly Lys Pro Ala Leu Gly Lys Ser Ile Leu 
            2020                2025                2030


Val Pro Asn Glu Glu Leu Ser Met Val Met Ser Ser Lys Lys Lys Leu 
        2035                2040                2045


Thr Lys Lys Thr Glu Ser Gln Ser Gln Lys Arg Ser Leu His Ser Val 
    2050                2055                2060


Ser Glu Glu Arg Thr Asp Glu Met Thr His Lys Glu Thr Asn Glu Gln 
2065                2070                2075                2080


Glu Glu Arg Leu Leu Ala Thr Ala Ser Phe Thr Lys Ser Ser Arg Ser 
                2085                2090                2095


Ser Arg Thr Arg Ser Ser Lys Ala Ile Leu Leu Pro Asp Leu Ser Glu 
            2100                2105                2110


Pro Asn Asn Glu Pro Leu Phe Ser Pro Ala Ser Glu Val Pro Arg Lys 
        2115                2120                2125


Ala Lys Ala Lys Lys Ile Glu Val Pro Ala Gln Leu Lys Glu Leu Val 
    2130                2135                2140


Ser Asp Leu Ser Ser Gln Phe Val Ile Ser Pro Pro Ala Leu Arg Ser 
2145                2150                2155                2160


Arg Gln Lys Asn Thr Ser Asn Lys Asn Lys Leu Glu Asp Glu Leu Lys 
                2165                2170                2175


Asp Asp Ala Gln Ser Val Glu Thr Leu Gly Lys Pro Lys Ala Lys Arg 
            2180                2185                2190


Ile Arg Thr Ser Lys Thr Lys Gln Ala Ser Lys Asn Thr Glu Lys Glu 
        2195                2200                2205


Ser Ala Trp Ser Pro Pro Pro Ile Glu Ile Arg Leu Ile Ser Pro Leu 
    2210                2215                2220


Ala Ser Pro Ala Asp Gly Val Lys Ser Lys Pro Arg Lys Thr Thr Glu 
2225                2230                2235                2240


Val Thr Gly Thr Gly Leu Gly Arg Asn Arg Lys Lys Leu Ser Ser Tyr 
                2245                2250                2255


Pro Lys Gln Ile Leu Arg Arg Lys Met Leu 
            2260                2265


<210>  120
<211>  3352
<212>  DNA
<213>  Homo sapiens

<400>  120
gtctccttgc ggccggcggg gtgctgggtt cccgtctgct gcctctcgga gagtcccggg     60

tgactgccgc aggctccatc gccctgtggc ctgcaggtat tgcgagattt atagggagga    120

cgctgggacc cccaaaagct gggaaatggg actattggca ttcagggatg tggctctaga    180

attctctcca gaggagtggg aatgcctgga cccagctcag cggagtttgt atagggatgt    240

gatgttagag aactacagaa acctgatctc ccttggtgag gatagcttca atatgcaatt    300

cctatttcac agtcttgcta tgtctaagcc agaactgatc atctgtctgg aggcaaggaa    360

agagccctgg aacgtgaaca cagagaagac agccagacac tcagttttgt cttcttatct    420

tactgaagac attttgccag agcagggcct gcaagtttca ttccaaaaag tgatgctgag    480

aagatatgaa agatgttgtc ttgagaaatt acgcttaagg aatgactggg aaattgtggg    540

tgagtggaaa gggcagaagg caagttataa tggacttgac ctatgctcag caactactca    600

tagcaaaaac tttcaatgca ataaatgtgt gaaaggtttt agtaaatttg caaatctaaa    660

taaatgtaag ataagccata ctggagaaaa accattcaaa tgcaaagaat gtggcaatgt    720

ctcttgcatg tctttaataa tgactcaaca gcagagaatc catattggag agaacccgta    780

ccaatgtaaa aaatgtggca aagcctttaa tgagtgctca tgctttactg actgtaagag    840

aattcatgtt ggagagaaac attgcaaatg tgaagaatgt aataacattt ttaagtcttg    900

ctcaagtctt gctgttgttg agaaaaatca tactgaaaag aaaacctaca gatgtgaaga    960

atgtggcaaa gcttttaacc tgtgctcagt tcttactaaa cataagaaaa ttcatactgg   1020

agagaaacca tacaaatgtg aagaatgtgg caaatccttt aagttgttcc cataccttac   1080

tcaacacaag agaattcata gtagagagaa accctacaag tgtgaagaat gtggcaaagt   1140

ctttaaattg ttgtcatacc ttactcaaca tagaagaatt catactggag agaaaacctt   1200

ccgatgtgaa gaatgtggaa aagcctttaa ccagagctca catctgactg aacataggag   1260

aattcatact ggtgagaaac catacaaatg tgaggaatgt ggcaaagctt ttacctggtt   1320

ctcatacctt attcagcata agagaattca tactgggcag aaaccctaca aatgtgagga   1380

atgtggcaaa gcttttacct ggttttcata ccttactcaa cataagagaa ttcatactgg   1440

agagaaaccc tacaaatgtg atgaatgtgg caaagctttt aactggtttt catatcttac   1500

taatcataag agaattcata ctggagagaa accctacaaa tgtgaagaat gtggcaaagc   1560

ctttggccag agctcacacc tttctaaaca taagacaatt cataccagag agaaaccata   1620

caagtgtgag gaatgtggca aagcctttaa ccactctgca caacttgctg tacatgagaa   1680

aactcatacc tgagaaaaac cctacaattc taaacaatat ggcatagtct ttaataccta   1740

ttcacaactt cacagcagaa tatttttact gaataagagt gttacaaatg taatgactgt   1800

caaaaggcca tttacagtct atgagccttt gagtgcacta aaatgtttag gctacgaaca   1860

atacaaatag accggttcaa cacctccact tatatcacag ctcttactgt acacagaaga   1920

atttatactg gagggaaacc ctccagttgc tcaaactgta ttcaatttca aagactttgt   1980

attggagaga aaccctacaa atgtaataaa tgcagaaaca acatttgttc aaaaaatata   2040

cctcagaaaa caccagagtg ttcacactaa aaactgtttt acagatgcag taaatgtgaa   2100

aaaatgtcta atcaaaaatt acatcaaaac acatccaaga attcatagta aaaagcacta   2160

agtcactgac actttcagac attactgtaa atctgagtgt tggttataga gaataattca   2220

aagttaagtt aaagtaagta ggagattcac cttttgggga agttataatt acatttcaag   2280

tatacctttt ggtgccaggc acggtggctc tttcctatag ttgctgcact tttggatgcc   2340

gaggtcgggg gattgcttga gcccaggagt ttgggaccag gctgggcaac atggcaaaac   2400

ctcatctcta caaaaagtaa aataaaagcc aggcttggtg gcacatgcct gttgtcccag   2460

ctacttggaa ggctcaggtg ggaggattgc ttgagcctgg aggttgagga tgcagtgagc   2520

tgctatctgg caacttcact cctgcctggg caacagagca agaccctttc tcaataataa   2580

taataacaac ataataataa agtatactcg gtgcactgaa agagttttag cttttttgaa   2640

aatcacatat ttatgtaatt caagtcttaa atcacttgat accatgcctt catttctagt   2700

gtttatgtga aggcatgagg cctactgttg ctacatgaaa gctgtgagag tttcttctat   2760

attcgggtgg gtgttgttca tatccttttc tttggaagat tatggacatt gcattgtaag   2820

cttcctgaag aaatttaact ggagaggctc tttgtacttg tcttataata gggttgtaag   2880

tgattcatga gataggtctt cagagtacta ttctgcatta tatttaagaa agaaacattt   2940

gagttttaca agtcagttgt ttttcctatt gcacattaag gtaataaaat tcagtggatt   3000

ttgaaatgct ctttttagac tgtttgaact taatttgttt taataagaca ttgttttaat   3060

gtctttggac cgttgtacat taagtgatgc gtatcctacc accaacgtta acctatctca   3120

ccttagttac ggttgtaggt aacaaatggt aacaatacaa tagtgggtaa catggtggaa   3180

tagtatctct aatgatccct tctcccagtg gcattaaact tcaaataatt tgaaaaatat   3240

tgttcccaca cgttacacct tcattctgtt tgctcttttt gtaatgacag tgtcattatt   3300

aaggctataa taaagcctat ataggattat aatcaaaaaa aaaaaaaaaa aa           3352


<210>  121
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  121

Met Gly Leu Leu Ala Phe Arg Asp Val Ala Leu Glu Phe Ser Pro Glu 
1               5                   10                  15


Glu Trp Glu Cys Leu Asp Pro Ala Gln Arg Ser Leu Tyr Arg Asp Val 
            20                  25                  30


Met Leu Glu Asn Tyr Arg Asn Leu Ile Ser Leu Gly Glu Asp Ser Phe 
        35                  40                  45


Asn Met Gln Phe Leu Phe His Ser Leu Ala Met Ser Lys Pro Glu Leu 
    50                  55                  60


Ile Ile Cys Leu Glu Ala Arg Lys Glu Pro Trp Asn Val Asn Thr Glu 
65                  70                  75                  80


Lys Thr Ala Arg His Ser Val Leu Ser Ser Tyr Leu Thr Glu Asp Ile 
                85                  90                  95


Leu Pro Glu Gln Gly Leu Gln Val Ser Phe Gln Lys Val Met Leu Arg 
            100                 105                 110


Arg Tyr Glu Arg Cys Cys Leu Glu Lys Leu Arg Leu Arg Asn Asp Trp 
        115                 120                 125


Glu Ile Val Gly Glu Trp Lys Gly Gln Lys Ala Ser Tyr Asn Gly Leu 
    130                 135                 140


Asp Leu Cys Ser Ala Thr Thr His Ser Lys Asn Phe Gln Cys Asn Lys 
145                 150                 155                 160


Cys Val Lys Gly Phe Ser Lys Phe Ala Asn Leu Asn Lys Cys Lys Ile 
                165                 170                 175


Ser His Thr Gly Glu Lys Pro Phe Lys Cys Lys Glu Cys Gly Asn Val 
            180                 185                 190


Ser Cys Met Ser Leu Ile Met Thr Gln Gln Gln Arg Ile His Ile Gly 
        195                 200                 205


Glu Asn Pro Tyr Gln Cys Lys Lys Cys Gly Lys Ala Phe Asn Glu Cys 
    210                 215                 220


Ser Cys Phe Thr Asp Cys Lys Arg Ile His Val Gly Glu Lys His Cys 
225                 230                 235                 240


Lys Cys Glu Glu Cys Asn Asn Ile Phe Lys Ser Cys Ser Ser Leu Ala 
                245                 250                 255


Val Val Glu Lys Asn His Thr Glu Lys Lys Thr Tyr Arg Cys Glu Glu 
            260                 265                 270


Cys Gly Lys Ala Phe Asn Leu Cys Ser Val Leu Thr Lys His Lys Lys 
        275                 280                 285


Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ser 
    290                 295                 300


Phe Lys Leu Phe Pro Tyr Leu Thr Gln His Lys Arg Ile His Ser Arg 
305                 310                 315                 320


Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Val Phe Lys Leu Leu 
                325                 330                 335


Ser Tyr Leu Thr Gln His Arg Arg Ile His Thr Gly Glu Lys Thr Phe 
            340                 345                 350


Arg Cys Glu Glu Cys Gly Lys Ala Phe Asn Gln Ser Ser His Leu Thr 
        355                 360                 365


Glu His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu 
    370                 375                 380


Cys Gly Lys Ala Phe Thr Trp Phe Ser Tyr Leu Ile Gln His Lys Arg 
385                 390                 395                 400


Ile His Thr Gly Gln Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala 
                405                 410                 415


Phe Thr Trp Phe Ser Tyr Leu Thr Gln His Lys Arg Ile His Thr Gly 
            420                 425                 430


Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Phe Asn Trp Phe 
        435                 440                 445


Ser Tyr Leu Thr Asn His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr 
    450                 455                 460


Lys Cys Glu Glu Cys Gly Lys Ala Phe Gly Gln Ser Ser His Leu Ser 
465                 470                 475                 480


Lys His Lys Thr Ile His Thr Arg Glu Lys Pro Tyr Lys Cys Glu Glu 
                485                 490                 495


Cys Gly Lys Ala Phe Asn His Ser Ala Gln Leu Ala Val His Glu Lys 
            500                 505                 510


Thr His Thr 
        515


<210>  122
<211>  2005
<212>  DNA
<213>  Homo sapiens

<400>  122
ggcgcggctt ttgtgttggg cagcgcgaat gtggcgagct cggtgcgtct ccgctgctcc     60

ttccccttat ccctgggagg tccaagtggt cccgcggcag cttctgttgc tctgggacct    120

gcaggtcccg gaaggtcctt agggaggacc ccagacaccg gagactggga aatggattca    180

gtgtcatttg aagatgtggc tgtggccttt actcaggagg agtgggcttt gctggatcct    240

tctcaaaaga atctctacag agatgtgatg caagaaatct tcaggaacct ggcttctgta    300

ggaaacaaat cagaagacca gaatatccaa gatgacttca aaaatcctgg gagaaatcta    360

agcagtcatg tggtagagag actgtttgaa attaaagaag gcagtcaata tggagaaacc    420

ttcagccagg attcaaattt gaatctgaat aagaaagttt ctactggagt aaagccatgt    480

gaatgcagtg tgtgtggaaa agtcttcata tgtcattcag cccttcatag gcacatcctg    540

tctcacattg gaaacaaact atttgagtgt gaggaatgtc cagagaagtt atatcattgc    600

aaacaatgtg ggaaagcctt tatctctctc accagtgttg acagacacat ggtaacacac    660

actagtaatg ggccttataa gggtccagtg tatgagaagc cttttgattt tcctagtgta    720

tttcaaatgc ctcagagcac ttacactgga gagaaaacat ataaatgtaa acattgtgat    780

aaagccttca attattcaag ttatcttcgt gaacatgaaa gaactcatac tggagagaaa    840

ccctatgcat gtaagaaatg tggtaaatca ttcacttttt ccagttctct tcgccaacat    900

gaaagatctc atactggaga gaaaccctat gaatgtaagg aatgtggcaa agccttcagt    960

cgttccactt acttgggaat acatgaaaga acgcatactg gagaaaaacc ctatgaatgt   1020

ataaaatgtg gcaaagcctt tagatgttcc agagtcctca gagtccatga aaggactcac   1080

agtggagaaa agccctatga atgtaaacaa tgtggtaaag ccttcaaata ttctagtaac   1140

ctatgtgagc atgaaagaac tcacactgga gtgaaacctt atggatgtaa ggaatgtggt   1200

aagtcgttta cttcttccag tgcccttcga agccatgaaa ggactcatac tggagaaaaa   1260

ccctatgaat gtaagaaatg tggtaaagcc ttcagttgtt ccagttccct tcgaaagcat   1320

gaaagagctt atatgtggta aaaaacaaca acaacaaaac acctctgtca atgtaagaag   1380

tgtgttaaag ctttcagtta ttctagtttc attagaacac gtgaaaaaat taaaaactca   1440

aattagagag aaacccaaca catgtaagga agattagaat gtatgcaatt ttcctagttc   1500

ccttctaaaa cttagaagga cccgtcctgg gaaagaacgt cataaaatac gaaaaatgtg   1560

ttagaacact ttattttccc agccgctttc aaatatattt ttatcagtgg ttcattgtta   1620

aagaaggtgt ctatacttta gattttcagt tttttgcagg gaatcatgga gctgagaatt   1680

tcacagatac tttataagcc atagtacatg agcttaatag gctgtgtttt gtttctcatc   1740

agttaacata atttttgtct attcatttaa aaatttgttg gatccctaga ctaagttgaa   1800

atgtatttct aatagtaggc aattttaatt ttcatgtagt tgtttaattg ttctctaatt   1860

aatggaccaa tgaaaaatga gttcatgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtat   1920

tctacctttt tatgggaaaa ctactttttt gttgtaaaga ttttcttctg ttttctttgc   1980

taataaagaa ttgttattaa tttgc                                         2005


<210>  123
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Asp Ser Val Ser Phe Glu Asp Val Ala Val Ala Phe Thr Gln Glu 
1               5                   10                  15


Glu Trp Ala Leu Leu Asp Pro Ser Gln Lys Asn Leu Tyr Arg Asp Val 
            20                  25                  30


Met Gln Glu Ile Phe Arg Asn Leu Ala Ser Val Gly Asn Lys Ser Glu 
        35                  40                  45


Asp Gln Asn Ile Gln Asp Asp Phe Lys Asn Pro Gly Arg Asn Leu Ser 
    50                  55                  60


Ser His Val Val Glu Arg Leu Phe Glu Ile Lys Glu Gly Ser Gln Tyr 
65                  70                  75                  80


Gly Glu Thr Phe Ser Gln Asp Ser Asn Leu Asn Leu Asn Lys Lys Val 
                85                  90                  95


Ser Thr Gly Val Lys Pro Cys Glu Cys Ser Val Cys Gly Lys Val Phe 
            100                 105                 110


Ile Cys His Ser Ala Leu His Arg His Ile Leu Ser His Ile Gly Asn 
        115                 120                 125


Lys Leu Phe Glu Cys Glu Glu Cys Pro Glu Lys Leu Tyr His Cys Lys 
    130                 135                 140


Gln Cys Gly Lys Ala Phe Ile Ser Leu Thr Ser Val Asp Arg His Met 
145                 150                 155                 160


Val Thr His Thr Ser Asn Gly Pro Tyr Lys Gly Pro Val Tyr Glu Lys 
                165                 170                 175


Pro Phe Asp Phe Pro Ser Val Phe Gln Met Pro Gln Ser Thr Tyr Thr 
            180                 185                 190


Gly Glu Lys Thr Tyr Lys Cys Lys His Cys Asp Lys Ala Phe Asn Tyr 
        195                 200                 205


Ser Ser Tyr Leu Arg Glu His Glu Arg Thr His Thr Gly Glu Lys Pro 
    210                 215                 220


Tyr Ala Cys Lys Lys Cys Gly Lys Ser Phe Thr Phe Ser Ser Ser Leu 
225                 230                 235                 240


Arg Gln His Glu Arg Ser His Thr Gly Glu Lys Pro Tyr Glu Cys Lys 
                245                 250                 255


Glu Cys Gly Lys Ala Phe Ser Arg Ser Thr Tyr Leu Gly Ile His Glu 
            260                 265                 270


Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Ile Lys Cys Gly Lys 
        275                 280                 285


Ala Phe Arg Cys Ser Arg Val Leu Arg Val His Glu Arg Thr His Ser 
    290                 295                 300


Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys Ala Phe Lys Tyr 
305                 310                 315                 320


Ser Ser Asn Leu Cys Glu His Glu Arg Thr His Thr Gly Val Lys Pro 
                325                 330                 335


Tyr Gly Cys Lys Glu Cys Gly Lys Ser Phe Thr Ser Ser Ser Ala Leu 
            340                 345                 350


Arg Ser His Glu Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys 
        355                 360                 365


Lys Cys Gly Lys Ala Phe Ser Cys Ser Ser Ser Leu Arg Lys His Glu 
    370                 375                 380


Arg Ala Tyr Met Trp 
385


<210>  124
<211>  1905
<212>  DNA
<213>  Homo sapiens

<400>  124
gttagtctcc gctgctagtt cttggctctg ggaggcccag gtggctctgc agcagcctct     60

gccaccctgt gacctgcgag tattgggaca tccctagctg acgccaggac acccgggaag    120

ccgaggaatg gtgagtggac tgcgcctggc ttcccgaagt ggagaagagg gctggttgaa    180

acctgctgtg gcgcgactcg ggcctccacg ccatcggctc cggaacctgc ggaccgagtc    240

gccgtggcgt agccggggct cagtcctctt ctgttcaggg ccgggccggg cggggcgggc    300

agcggaaccc ctgcatcctg tctgtacctg cgggcgccac ttccgccggc cggatccctg    360

tcgggaaccc ctcgcctccc ctatccagga ctcggtggct tttgaggatg tggctgtgaa    420

ctttacccag gaggaatggg ctttgctaga ttcttctcag aagaatctct acagagaagt    480

gatgcaggaa acctgtagga acctggcttc tgtaggaagc caatggaaag accagaatat    540

tgaagatcac ttcgaaaaac ctgggaaaga tataagaaat catatcgtac agagactgtg    600

tgaaagtaaa gaagatggtc agtatggaga agttgtcagc caaattccaa atcttgatct    660

gaacgagaac atttctactg gattaaaacc atgtgaatgc agtatttgtg gaaaagtctt    720

tgtacgtcat tccctcttta ataggcatat cctagctcac tcaggataca aaccatatgg    780

agagaagcaa tataaatgtg aacagtgtgg gaaattcttc gtttctgttc caggtgttag    840

aagacacatg ataatgcaca gtggaaatcc agcttataaa tgtacgatat gtgggaaagc    900

tttttatttt ctcaattcag ttgaaagaca tcagagaact cacacaggag aaaaacccta    960

taaatgtaaa caatgtggta aagcattcac tgtttccggt tcttgtctaa tacatgaacg   1020

aactcacact ggagagaaac cctacgaatg taaggaatgt gggaaaacat tcagattttc   1080

ttgttctttt aagacgcatg aaaggactca cactggagaa agaccctata aatgtaccaa   1140

atgtgataaa gccttcagct gttccacttc ccttcgttac catggaagca ttcatactgg   1200

agagagaccc tatgagtgta aacaatgtgg caaagccttt agtcgtttga gttccctttg   1260

taaccataga agtactcata ccggagagaa accctatgaa tgtaaacaat gtgatcaagc   1320

cttcagtcgc ctcagttccc ttcacctcca cgaaagaatt catactggag aaaaacccta   1380

tgaatgtaag aaatgcggta aagcctacac tcgttccagt caccttactc gccatgaaag   1440

aagtcatgat atagaggctg ggtgtagtga ctcagcctat aatcccagca ctttgggagg   1500

ccaaggcgtg tggattgctt gagcccagga gttcataacc agcctggatt aaaacaatgt   1560

gaaacaacct gggcaacatg gtgaaaccct gtctttacaa aaaataaaat aatgccgggc   1620

acggtggctt acgcctgtaa tcccagcact ttgggaggcc gaggcgggtg gatcacgagg   1680

tcaggagatc gagaccatcc tggccaacac ggtgaaaccc cgtctctact aaaaatacaa   1740

aaaattagct gggcgtggtg gcgggcgcct gtggtcccag ttactcgggg ggctgaggca   1800

ggagaatggc atgaacccgg gaggcggaac ttgcggtgag ccgagatcgc accactgcac   1860

ttcagcctgg gtgacagagt gagactctgt ctcaaaaaat aagat                   1905


<210>  125
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Val Ser Gly Leu Arg Leu Ala Ser Arg Ser Gly Glu Glu Gly Trp 
1               5                   10                  15


Leu Lys Pro Ala Val Ala Arg Leu Gly Pro Pro Arg His Arg Leu Arg 
            20                  25                  30


Asn Leu Arg Thr Glu Ser Pro Trp Arg Ser Arg Gly Ser Val Leu Phe 
        35                  40                  45


Cys Ser Gly Pro Gly Arg Ala Gly Arg Ala Ala Glu Pro Leu His Pro 
    50                  55                  60


Val Cys Thr Cys Gly Arg His Phe Arg Arg Pro Asp Pro Cys Arg Glu 
65                  70                  75                  80


Pro Leu Ala Ser Pro Ile Gln Asp Ser Val Ala Phe Glu Asp Val Ala 
                85                  90                  95


Val Asn Phe Thr Gln Glu Glu Trp Ala Leu Leu Asp Ser Ser Gln Lys 
            100                 105                 110


Asn Leu Tyr Arg Glu Val Met Gln Glu Thr Cys Arg Asn Leu Ala Ser 
        115                 120                 125


Val Gly Ser Gln Trp Lys Asp Gln Asn Ile Glu Asp His Phe Glu Lys 
    130                 135                 140


Pro Gly Lys Asp Ile Arg Asn His Ile Val Gln Arg Leu Cys Glu Ser 
145                 150                 155                 160


Lys Glu Asp Gly Gln Tyr Gly Glu Val Val Ser Gln Ile Pro Asn Leu 
                165                 170                 175


Asp Leu Asn Glu Asn Ile Ser Thr Gly Leu Lys Pro Cys Glu Cys Ser 
            180                 185                 190


Ile Cys Gly Lys Val Phe Val Arg His Ser Leu Phe Asn Arg His Ile 
        195                 200                 205


Leu Ala His Ser Gly Tyr Lys Pro Tyr Gly Glu Lys Gln Tyr Lys Cys 
    210                 215                 220


Glu Gln Cys Gly Lys Phe Phe Val Ser Val Pro Gly Val Arg Arg His 
225                 230                 235                 240


Met Ile Met His Ser Gly Asn Pro Ala Tyr Lys Cys Thr Ile Cys Gly 
                245                 250                 255


Lys Ala Phe Tyr Phe Leu Asn Ser Val Glu Arg His Gln Arg Thr His 
            260                 265                 270


Thr Gly Glu Lys Pro Tyr Lys Cys Lys Gln Cys Gly Lys Ala Phe Thr 
        275                 280                 285


Val Ser Gly Ser Cys Leu Ile His Glu Arg Thr His Thr Gly Glu Lys 
    290                 295                 300


Pro Tyr Glu Cys Lys Glu Cys Gly Lys Thr Phe Arg Phe Ser Cys Ser 
305                 310                 315                 320


Phe Lys Thr His Glu Arg Thr His Thr Gly Glu Arg Pro Tyr Lys Cys 
                325                 330                 335


Thr Lys Cys Asp Lys Ala Phe Ser Cys Ser Thr Ser Leu Arg Tyr His 
            340                 345                 350


Gly Ser Ile His Thr Gly Glu Arg Pro Tyr Glu Cys Lys Gln Cys Gly 
        355                 360                 365


Lys Ala Phe Ser Arg Leu Ser Ser Leu Cys Asn His Arg Ser Thr His 
    370                 375                 380


Thr Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Asp Gln Ala Phe Ser 
385                 390                 395                 400


Arg Leu Ser Ser Leu His Leu His Glu Arg Ile His Thr Gly Glu Lys 
                405                 410                 415


Pro Tyr Glu Cys Lys Lys Cys Gly Lys Ala Tyr Thr Arg Ser Ser His 
            420                 425                 430


Leu Thr Arg His Glu Arg Ser His Asp Ile Glu Ala Gly Cys Ser Asp 
        435                 440                 445


Ser Ala Tyr Asn Pro Ser Thr Leu Gly Gly Gln Gly Val Trp Ile Ala 
    450                 455                 460


<210>  126
<211>  1114
<212>  DNA
<213>  Homo sapiens

<400>  126
ggagcaggat cggggaggac acacaggtgg gcgtctcaag aactgtggtg tacacagctg     60

agcccctgca gctctgcttt gccgggcctc accctcggtg ctgggtgcaa gacgtgacaa    120

gatggcatgg gaagcttccc ggggaacgct ggaactgggt gtttgaagga ggacctcatg    180

gcggcagctc cagcccaagt actgcaactg tggggccgtg ccaggagcag gtgctgcgga    240

gcctgtgtgg gtccaggaca agaggagcac cagaagctcc tggagggcgg tgcagacgac    300

actgtcgggc cggcccagcc caggccccag cagttgactc ctctgtgatc agaggatgtg    360

gctgaggatg tgcatttccg tcaagttccc aggagaacct ggtgctgctg cttcggggac    420

cccactttga ggaccactga tctaacactg cccctcgtgg caaacgcgga atgactcaag    480

attcagctgg atggatcatt cagggagcaa atccaccctt gccgcctggc acaccctggc    540

cattcggtaa cgatgccatc agggttactg gcttcttcat tctccactgt gcattccagg    600

gtgggcattt ccacagttgt gagcccatca tcaactcagc gagttcccat tttccagtta    660

gaaaataagc tttctgatcg ttagccattc acttcaattg gctctagaaa agatttctgg    720

gatgtataat ttatttttaa cataaagaaa agctaagtgt aaactagata agctacaatt    780

gtcccagacg ttatagacac tcacagcacc gttttcctct tctagcaaaa caaaacaaaa    840

aattctgcaa tcatacaggc agtaggaaaa aaaaattagc tggacaccat ggctcacacc    900

tgtaacccca gcactttggg aggccgaggt gggaggatca cttgaggcca ggagttaggg    960

actggcctgg gcaacatagt gagatcccat ctttataaaa ataaaaaaaa tctgggcgtg   1020

gtggagcaca cttgtggtcc tagctactca ggaggctgag agtggggaat cgtttgatcc   1080

caggaggttg aggctggagt gaaccatgtt tgca                               1114


<210>  127
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  127

Met Ala Ala Ala Pro Ala Gln Val Leu Gln Leu Trp Gly Arg Ala Arg 
1               5                   10                  15


Ser Arg Cys Cys Gly Ala Cys Val Gly Pro Gly Gln Glu Glu His Gln 
            20                  25                  30


Lys Leu Leu Glu Gly Gly Ala Asp Asp Thr Val Gly Pro Ala Gln Pro 
        35                  40                  45


Arg Pro Gln Gln Leu Thr Pro Leu 
    50                  55


<210>  128
<211>  1628
<212>  DNA
<213>  Homo sapiens

<400>  128
gagcgcggcc cctgggttcg aacacggcac ccgcactgcg cgtcatggtg ctggcctggt     60

atatggacga cgccccgggc gacccgcggc aaccccaccg ccccgacccc ggccgcccag    120

tgggcctgga gcagctgcgg cggctcgggg tgctctactg gaagctggat gctgacaaat    180

atgagaatga tccagaatta gaaaagatcc gaagagagag gaactactcc tggatggaca    240

tcataaccat atgcaaagat aaactaccaa attatgaaga aaagattaag atgttctacg    300

aggagcattt gcacttggac gatgagatcc gctacatcct ggatggcagt gggtacttcg    360

acgtgaggga caaggaggac cagtggatcc ggatcttcat ggagaaggga gacatggtga    420

cgctccccgc ggggatctat caccgcttca cggtggacga gaagaactac acgaaggcca    480

tgcggctgtt tgtgggagaa ccggtgtgga cagcgtacaa ccggcccgct gaccattttg    540

aagcccgcgg gcagtacgtg aaatttctgg cacagaccgc ctagcagtgc tgcctgggaa    600

ctaacacgtg cctcgtaaag gtccccaatg taatgactga gcagaaaatc aatcactttc    660

tctttgcttt tagaggatag ccttgaggct agattatctt tcctttgtaa gattatttga    720

tcagaatatt ttgtaatgaa aggatctaga aagcaacttg gaagtgtaaa gagtcacctt    780

cattttctgt aactcaatca agactggtgg gtccatggcc ctgtgttagt tcatgcattc    840

agttgagtcc caaatgaaag tttcatctcc cgaaatgcag ttccttagat gcccatctgg    900

acgtgatgcc gcgcctgccg tgtaagaagg tgcaatccta gataacacag ctagccagat    960

agaagacact tttttctcca aaatgatgcc ttggggtggg gagtggtagt gggaagagct   1020

cccaccctaa ggggcacaca ctgagttgct tatgccactt ccttgttcaa aataaagtaa   1080

ctgccttaat cttatactca tggcttggag ttaccttata ttcaggtata tgtgatattt   1140

tgcctggttt gttaaaattg ccccatttag attccttcta taattgttct tatagataag   1200

taatttatat atgagctgtg ttagtatttt tttcagtgtg agatctctgg attctttcac   1260

aataaagctg ttgaatttta acaggagtat tagtacataa attttctact caacaattcc   1320

gagataggat tatgcctagt ttgtcatatc acagaaaaac tccaagttaa cttcatgttt   1380

tggaagggca ggtcgttttt aaagtatttc tttttttaac tggatgaaaa atcttcatgt   1440

taggattaat tttcttaatc acctccacac tgtacagagg aaactcaagc cttaaatgtt   1500

taagtaaact ctgtctcagt tttaggatta aaatacccac cggtggtgtg atgatgccat   1560

ataccgcagg gcttgcttct gtcaagtgtg actctatctc agtaattaaa ataagtgctg   1620

atctactg                                                            1628


<210>  129
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Val Leu Ala Trp Tyr Met Asp Asp Ala Pro Gly Asp Pro Arg Gln 
1               5                   10                  15


Pro His Arg Pro Asp Pro Gly Arg Pro Val Gly Leu Glu Gln Leu Arg 
            20                  25                  30


Arg Leu Gly Val Leu Tyr Trp Lys Leu Asp Ala Asp Lys Tyr Glu Asn 
        35                  40                  45


Asp Pro Glu Leu Glu Lys Ile Arg Arg Glu Arg Asn Tyr Ser Trp Met 
    50                  55                  60


Asp Ile Ile Thr Ile Cys Lys Asp Lys Leu Pro Asn Tyr Glu Glu Lys 
65                  70                  75                  80


Ile Lys Met Phe Tyr Glu Glu His Leu His Leu Asp Asp Glu Ile Arg 
                85                  90                  95


Tyr Ile Leu Asp Gly Ser Gly Tyr Phe Asp Val Arg Asp Lys Glu Asp 
            100                 105                 110


Gln Trp Ile Arg Ile Phe Met Glu Lys Gly Asp Met Val Thr Leu Pro 
        115                 120                 125


Ala Gly Ile Tyr His Arg Phe Thr Val Asp Glu Lys Asn Tyr Thr Lys 
    130                 135                 140


Ala Met Arg Leu Phe Val Gly Glu Pro Val Trp Thr Ala Tyr Asn Arg 
145                 150                 155                 160


Pro Ala Asp His Phe Glu Ala Arg Gly Gln Tyr Val Lys Phe Leu Ala 
                165                 170                 175


Gln Thr Ala 



<210>  130
<211>  676
<212>  DNA
<213>  Homo sapiens

<400>  130
ccagagagtg agcagggcag aaaaaaactt ctattgcatg atggaacagc tcccagcgtt     60

gaggggacct gagagtgggc agccactacc tgaagctctt ggaacagaac cagacttctg    120

gccggggctc agtcagtgct tgcaagatgt ttgttggcac caggctgtgc caggagagca    180

tcattataaa ctgctgatct actgtttctt tgtcaaacgg gaggagataa catgagggtc    240

atgagaaatg tttgcagacg gagtgaatgc cttgaaagtg ctgcgaccag gtgctgacac    300

ccggaggtct ggctgctcaa agtgttagct gacacggaag acacacggac tttccctcca    360

ttccccaaaa ctccccttcc ctgactcgtc agctgcataa aaaccctctc cttatctctt    420

tgtcaagggg atttgagaaa tcttgctgtc ttgtcttctt gctttggcca aatggaataa    480

acctttctct gtctccagac acctatgtcg cagtgttcgg cctcagctat acggcaggta    540

catgaacctg gtatttgggc ttctacaaca attgtactta tagcacaaat aaagtacaaa    600

gtgttaggga agaccaaaga ccataggtag aaaacttgga tacaacttcc aaataaacac    660

tcttcaaaac atttaa                                                    676


<210>  131
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  131

Met Glu Gln Leu Pro Ala Leu Arg Gly Pro Glu Ser Gly Gln Pro Leu 
1               5                   10                  15


Pro Glu Ala Leu Gly Thr Glu Pro Asp Phe Trp Pro Gly Leu Ser Gln 
            20                  25                  30


Cys Leu Gln Asp Val Cys Trp His Gln Ala Val Pro Gly Glu His His 
        35                  40                  45


Tyr Lys Leu Leu Ile Tyr Cys Phe Phe Val Lys Arg Glu Glu Ile Thr 
    50                  55                  60


<210>  132
<211>  979
<212>  DNA
<213>  Homo sapiens

<400>  132
tctttcctcc ccttctgcgc ggtcacgccg agccagcgcc tgggcctgga accaggccac     60

agccccccag cttcacccac cacctcccta ccatggaccc ccgcaaagtg aatgagcttc    120

gggcctttgt gaacatgtgt aagcaggatc tgagtgttct gcacaccgag gaaatgtgct    180

tcctgaggga gtgggtggag agcctgcggg taaagtacca cctgctactc agaaagctaa    240

atcagaagaa aatgccaagg aagaaaaacc taatagtaag aaggtggagg aagacttaaa    300

ggcagacgaa ccatcaagtg aggaaagtga tctagaaatt gacaaagaag gtgtgattga    360

accagacact gatgcccctc aagaaatggg aggtgaaaat gcagagataa cggaggagat    420

gatggatcag gcaaatgata agaaagtggc tgctattgaa gccctaaatg atggtgaact    480

ccagaaagcc attgacttat tcacagatgc catcaagctg aatcctcgct tggctgtttt    540

gtatgccaag agggccagtg tcttcgtcaa attacagaag ccaaatgctg ccatccgaga    600

ctgtgacaga gccattgaaa taaatcctga ttcagctcag cctcacaagt ggcgagggaa    660

agcacataga cttctaggcc actgggaaga agcagcccat gatcttgccc ttgcctgtaa    720

attggattat gatgaagatg ctagtgtaat gctgaaagaa gttcaactta gggcacagaa    780

aattgcagaa catcagagaa agtatgagca aaaacgtgaa gagtgagaga tcaaagcaag    840

aatagaatga gttaagaagg ctcgagaaga gcatgagagg gaggaagaag ccagaccgca    900

gtcaggagct cagtatggct cttttccagg tggctttcct gggggaatgc ctggcaattt    960

tcccagagga atgcctgga                                                 979


<210>  133
<211>  5063
<212>  DNA
<213>  Homo sapiens

<400>  133
atggggctgc ggccaggcat tttcctcctg gagctgctgc tgcttctggg gcaagggacc     60

cctcagatcc atacctctcc tagaaagagt acattggaag ggcagctatg gccagagacc    120

ctgaagaatt ctccattccc atgcaaccca aataaattag gagtgaatat gccttctaaa    180

tcagttcact ctctgaagcc ttctgatatt aaatttgtgg cagccattgg caatctggaa    240

attcctccag acccagggac gggcgatctg gagaagcaag actggactga aaggccacag    300

caggtgtgca tgggagtgat gacagtcctt tcagacatca tcagatattt cagtccttct    360

gttccaatgc ctgtgtgcca cactggaaag agagtcatac cccacgatgg tgctgaagac    420

ttgtggattc aggctcaaga actggtgaga aacatgaaag agaacctgca acttgacttt    480

caatttgact ggaagctcat caatgtgttc ttcagtaatg caagccagtg ttacctgtgc    540

ccctctgctc aacagaatgg gcttgcggcg ggcggcgtgg atgagctgat gggggtgctg    600

gactacctgc agcaggaggt ccccagagca tttgtaaacc tggtggacct ctctgaggtt    660

gcagaggtct ctcgtcagta tcacggcact tggctcagcc ctgcaccaga gccctgtaat    720

tgctcagagg agaccacccg gctggccaag gtggtgatgc agtggtctta tcaggaagcc    780

tggaacagcc tcctggcctc cagcaggtac agtgagcagg agtccttcac cgtggttttc    840

cagcctttct tctatgagac caccccatct ctacactcgg aggacccccg actccaggat    900

tctaccacgc tggcctggca tctctggaat aggatgatgg agccagcagg agagaaagat    960

gagccattga gtgtaaaaca cgggaggcca atgaagtgtc cctctcagga gagcccctat   1020

ctgttcagct acagaaacag caactacctg accagactgc agaaacccca agacaagctt   1080

gaggtaagag aaggagcgga aatcagatgt cctgacaaag acccctccga tacggttccc   1140

acctcagttc ataggctgaa gccggctgac atcaacgtaa ttggagccct gggtgactct   1200

ctcacggcag gcaatggggc cgggtccaca cctgggaacg tcttggacgt cttgactcag   1260

taccgaggcc tgtcctggag cgtcggcgga gatgagaaca tcggcaccgt taccaccctg   1320

gcgaacatcc tccgggaatt caacccttcc ctgaagggct tctctgttgg cactgggaaa   1380

gaaaccagtc ctaatgcctt cttaaaccag gctgtggcag gaggccgagc tgaggatcta   1440

cctgtccagg ccaggaggct ggtggacctg atgaagaatg acacgaggat acactttcag   1500

gaagactgga agataataac cctgtttata ggcggcaatg acctctgtga tttctgcaat   1560

gatctggtcc actattctcc ccagaacttc acagacaaca ttggaaaggc cctggacatc   1620

ctccatgctg aggttcctcg ggcatttgtg aacctggtga cggtgcttga gatcgtcaac   1680

ctgagggagc tgtaccagga gaaaaaagtc tactgcccaa ggatgatcct caggtctctg   1740

tgtccctgtg tcctgaagtt tgatgataac tcaacagaac ttgctaccct catcgaattc   1800

aacaagaagt ttcaggagaa gacccaccaa ctgattgaga gtgggcgata tgacacaagg   1860

gaagatttta ctgtggttgt gcagccgttc tttgaaaacg tggacatgcc aaagacctcg   1920

gaaggattgc ctgacaactc tttcttcgct cctgactgtt tccacttcag cagcaagtct   1980

cactcccgag cagccagtgc tctctggaac aatatgctgg agcctgttgg ccagaagacg   2040

actcgtcata agtttgaaaa caagatcaat atcacatgtc cgaaccaggt ccagccgttt   2100

ctgaggacct acaagaacag catgcagggt catgggacct ggctgccatg cagggacaga   2160

gccccttctg ccttgcaccc tacctcagtg catgccctga gacctgcaga catccaagtt   2220

gtggctgctc tgggggattc tctgaccgct ggcaatggaa ttggctccaa accagacgac   2280

ctccccgatg tcaccacaca gtatcgggga ctgtcataca gtgcaggagg ggacggctcc   2340

ctggagaatg tgaccacctt acctaatatc cttcgggagt ttaacagaaa cctcacaggc   2400

tacgccgtgg gcacgggtga tgccaatgac acgaatgcat tcctcaatca agctgttccc   2460

ggagcaaagg ctgaggatct tatgagccaa gtccaaactc tgatgcagaa gatgaaagat   2520

gatcatagag taaatttcca tgaagactgg aaggtcatca cagtgctgat cggaggcagc   2580

gatttatgtg actactgcac agattcgaat ctgtattctg cagccaactt tgttgaccat   2640

ctccgcaatg ccttggacgt cctgcataga gaggtgccca gagtcctggt caacctcgtg   2700

gacttcctga accccactat catgcggcag gtgttcctgg gaaacccaga caagtgccca   2760

gtgcagcagg ccagcgtttt gtgtaactgc gttctgaccc tgcgggagaa ctcccaagag   2820

ctagccaggc tggaggcctt cagccgagcc taccggagca gcatgcgcga gctggtgggg   2880

tcaggccgct atgacacgca ggaggacttc tctgtggtgc tgcagccctt cttccagaac   2940

atccagctcc ctgtcctggc ggatgggctc ccagatacgt ccttctttgc cccagactgc   3000

atccacccaa atcagaaatt ccactcccag ctggccagag ccctttggac caatatgctt   3060

gaaccacttg gaagcaaaac agagaccctg gacctgagag cagagatgcc catcacctgt   3120

cccactcaga atgagccctt cctgagaacc cctcggaata gtaactacac gtaccccatc   3180

aagccagcca ttgagaactg gggcagtgac ttcctgtgta cagagtggaa ggcttccaat   3240

agtgttccaa cctctgtcca ccagctccga ccagcagaca tcaaagtggt ggccgccctg   3300

ggtgactctc tgactacagc agtgggagct cgaccaaaca actccagtga cctacccaca   3360

tcttggaggg gactctcttg gagcattgga ggggatggga acttggagac tcacaccaca   3420

ctgcccaaca ttctgaagaa gttcaaccct tacctccttg gcttctctac cagcacctgg   3480

gaggggacag caggactaaa tgtggcagcg gaaggggcca gagctaggga catgccagcc   3540

caggcctggg acctggtaga gcgaatgaaa aacagccccg acatcaacct ggagaaagac   3600

tggaagctgg tcacactctt cattggggtc aacgacttgt gtcattactg tgagaatccg   3660

gaggcccact tggccacgga atatgttcag cacatccaac aggccctgga catcctctct   3720

gaggagctcc caagggcttt cgtcaacgtg gtggaggtca tggagctggc tagcctgtac   3780

cagggccaag gcgggaaatg tgccatgctg gcagctcaga acaactgcac ttgcctcaga   3840

cactcgcaaa gctccctgga gaagcaagaa ctgaagaaag tgaactggaa cctccagcat   3900

ggcatctcca gtttctccta ctggcaccaa tacacacagc gtgaggactt tgcggttgtg   3960

gtgcagcctt tcttccaaaa cacactcacc ccactgaacg agagagggga cactgacctc   4020

accttcttct ccgaggactg ttttcacttc tcagaccgcg ggcatgccga gatggccatc   4080

gcactctgga acaacatgct ggaaccagtg ggccgcaaga ctacctccaa caacttcacc   4140

cacagccgag ccaaactcaa gtgcccctct cctgagagcc cttacctcta caccctgcgg   4200

aacagccgat tgctcccaga ccaggctgaa gaagcccccg aggtgctcta ctgggctgtc   4260

ccagtggcag cgggagtcgg ccttgtggtg ggcatcatcg ggacagtggt ctggaggtgc   4320

aggagaggtg gccggaggga agatcctcca atgagcctgc gcactgtggc cctctaggcc   4380

cgggggtggg tcctcaccct aaactcccta tagccactct cttcaccgcc ctctgcccca   4440

gccactcccg gccaccagga catgcttcaa tgcctggtgc cataggaagc ccaggggaca   4500

gtcacaactt cttggggcct gggcttcttc caggcctatg ctcctggaat ggatacattt   4560

aaataaagtc caaagctatt ttattcctgg gtttgcctgc gtgaagcact caccttccat   4620

ctcttgtgca gcccaggtgt gggagctgcc actttttgtg gcctgcctcc agcagggctg   4680

cccaagccac gaccaaccag agcccaaact gcctgccacc acgagcatat cctcaagtca   4740

ccaaacccac tatttcaaag gcagaaaaaa tgctggtcac caggtggtgg ctggaatttt   4800

ggagctggct ggttgccatt cagtccaatc caacacatac ctattaagca actgttttgt   4860

atccaggaca atgcgaagca ctgaggtgcc tcctaggctg tgcatgtcgc agcctggcag   4920

agaggtcaaa ctccttcaat aaccaagaag ccacgtgatg atgtgtaact actagggcat   4980

cagtaggtaa atgtgtctga ttgttttaaa gaatagaaag ggttcttcgg ggaaagtttc   5040

ttgggggaga gcaaccttca cat                                           5063


<210>  134
<211>  1458
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Gly Leu Arg Pro Gly Ile Phe Leu Leu Glu Leu Leu Leu Leu Leu 
1               5                   10                  15


Gly Gln Gly Thr Pro Gln Ile His Thr Ser Pro Arg Lys Ser Thr Leu 
            20                  25                  30


Glu Gly Gln Leu Trp Pro Glu Thr Leu Lys Asn Ser Pro Phe Pro Cys 
        35                  40                  45


Asn Pro Asn Lys Leu Gly Val Asn Met Pro Ser Lys Ser Val His Ser 
    50                  55                  60


Leu Lys Pro Ser Asp Ile Lys Phe Val Ala Ala Ile Gly Asn Leu Glu 
65                  70                  75                  80


Ile Pro Pro Asp Pro Gly Thr Gly Asp Leu Glu Lys Gln Asp Trp Thr 
                85                  90                  95


Glu Arg Pro Gln Gln Val Cys Met Gly Val Met Thr Val Leu Ser Asp 
            100                 105                 110


Ile Ile Arg Tyr Phe Ser Pro Ser Val Pro Met Pro Val Cys His Thr 
        115                 120                 125


Gly Lys Arg Val Ile Pro His Asp Gly Ala Glu Asp Leu Trp Ile Gln 
    130                 135                 140


Ala Gln Glu Leu Val Arg Asn Met Lys Glu Asn Leu Gln Leu Asp Phe 
145                 150                 155                 160


Gln Phe Asp Trp Lys Leu Ile Asn Val Phe Phe Ser Asn Ala Ser Gln 
                165                 170                 175


Cys Tyr Leu Cys Pro Ser Ala Gln Gln Asn Gly Leu Ala Ala Gly Gly 
            180                 185                 190


Val Asp Glu Leu Met Gly Val Leu Asp Tyr Leu Gln Gln Glu Val Pro 
        195                 200                 205


Arg Ala Phe Val Asn Leu Val Asp Leu Ser Glu Val Ala Glu Val Ser 
    210                 215                 220


Arg Gln Tyr His Gly Thr Trp Leu Ser Pro Ala Pro Glu Pro Cys Asn 
225                 230                 235                 240


Cys Ser Glu Glu Thr Thr Arg Leu Ala Lys Val Val Met Gln Trp Ser 
                245                 250                 255


Tyr Gln Glu Ala Trp Asn Ser Leu Leu Ala Ser Ser Arg Tyr Ser Glu 
            260                 265                 270


Gln Glu Ser Phe Thr Val Val Phe Gln Pro Phe Phe Tyr Glu Thr Thr 
        275                 280                 285


Pro Ser Leu His Ser Glu Asp Pro Arg Leu Gln Asp Ser Thr Thr Leu 
    290                 295                 300


Ala Trp His Leu Trp Asn Arg Met Met Glu Pro Ala Gly Glu Lys Asp 
305                 310                 315                 320


Glu Pro Leu Ser Val Lys His Gly Arg Pro Met Lys Cys Pro Ser Gln 
                325                 330                 335


Glu Ser Pro Tyr Leu Phe Ser Tyr Arg Asn Ser Asn Tyr Leu Thr Arg 
            340                 345                 350


Leu Gln Lys Pro Gln Asp Lys Leu Glu Val Arg Glu Gly Ala Glu Ile 
        355                 360                 365


Arg Cys Pro Asp Lys Asp Pro Ser Asp Thr Val Pro Thr Ser Val His 
    370                 375                 380


Arg Leu Lys Pro Ala Asp Ile Asn Val Ile Gly Ala Leu Gly Asp Ser 
385                 390                 395                 400


Leu Thr Ala Gly Asn Gly Ala Gly Ser Thr Pro Gly Asn Val Leu Asp 
                405                 410                 415


Val Leu Thr Gln Tyr Arg Gly Leu Ser Trp Ser Val Gly Gly Asp Glu 
            420                 425                 430


Asn Ile Gly Thr Val Thr Thr Leu Ala Asn Ile Leu Arg Glu Phe Asn 
        435                 440                 445


Pro Ser Leu Lys Gly Phe Ser Val Gly Thr Gly Lys Glu Thr Ser Pro 
    450                 455                 460


Asn Ala Phe Leu Asn Gln Ala Val Ala Gly Gly Arg Ala Glu Asp Leu 
465                 470                 475                 480


Pro Val Gln Ala Arg Arg Leu Val Asp Leu Met Lys Asn Asp Thr Arg 
                485                 490                 495


Ile His Phe Gln Glu Asp Trp Lys Ile Ile Thr Leu Phe Ile Gly Gly 
            500                 505                 510


Asn Asp Leu Cys Asp Phe Cys Asn Asp Leu Val His Tyr Ser Pro Gln 
        515                 520                 525


Asn Phe Thr Asp Asn Ile Gly Lys Ala Leu Asp Ile Leu His Ala Glu 
    530                 535                 540


Val Pro Arg Ala Phe Val Asn Leu Val Thr Val Leu Glu Ile Val Asn 
545                 550                 555                 560


Leu Arg Glu Leu Tyr Gln Glu Lys Lys Val Tyr Cys Pro Arg Met Ile 
                565                 570                 575


Leu Arg Ser Leu Cys Pro Cys Val Leu Lys Phe Asp Asp Asn Ser Thr 
            580                 585                 590


Glu Leu Ala Thr Leu Ile Glu Phe Asn Lys Lys Phe Gln Glu Lys Thr 
        595                 600                 605


His Gln Leu Ile Glu Ser Gly Arg Tyr Asp Thr Arg Glu Asp Phe Thr 
    610                 615                 620


Val Val Val Gln Pro Phe Phe Glu Asn Val Asp Met Pro Lys Thr Ser 
625                 630                 635                 640


Glu Gly Leu Pro Asp Asn Ser Phe Phe Ala Pro Asp Cys Phe His Phe 
                645                 650                 655


Ser Ser Lys Ser His Ser Arg Ala Ala Ser Ala Leu Trp Asn Asn Met 
            660                 665                 670


Leu Glu Pro Val Gly Gln Lys Thr Thr Arg His Lys Phe Glu Asn Lys 
        675                 680                 685


Ile Asn Ile Thr Cys Pro Asn Gln Val Gln Pro Phe Leu Arg Thr Tyr 
    690                 695                 700


Lys Asn Ser Met Gln Gly His Gly Thr Trp Leu Pro Cys Arg Asp Arg 
705                 710                 715                 720


Ala Pro Ser Ala Leu His Pro Thr Ser Val His Ala Leu Arg Pro Ala 
                725                 730                 735


Asp Ile Gln Val Val Ala Ala Leu Gly Asp Ser Leu Thr Ala Gly Asn 
            740                 745                 750


Gly Ile Gly Ser Lys Pro Asp Asp Leu Pro Asp Val Thr Thr Gln Tyr 
        755                 760                 765


Arg Gly Leu Ser Tyr Ser Ala Gly Gly Asp Gly Ser Leu Glu Asn Val 
    770                 775                 780


Thr Thr Leu Pro Asn Ile Leu Arg Glu Phe Asn Arg Asn Leu Thr Gly 
785                 790                 795                 800


Tyr Ala Val Gly Thr Gly Asp Ala Asn Asp Thr Asn Ala Phe Leu Asn 
                805                 810                 815


Gln Ala Val Pro Gly Ala Lys Ala Glu Asp Leu Met Ser Gln Val Gln 
            820                 825                 830


Thr Leu Met Gln Lys Met Lys Asp Asp His Arg Val Asn Phe His Glu 
        835                 840                 845


Asp Trp Lys Val Ile Thr Val Leu Ile Gly Gly Ser Asp Leu Cys Asp 
    850                 855                 860


Tyr Cys Thr Asp Ser Asn Leu Tyr Ser Ala Ala Asn Phe Val Asp His 
865                 870                 875                 880


Leu Arg Asn Ala Leu Asp Val Leu His Arg Glu Val Pro Arg Val Leu 
                885                 890                 895


Val Asn Leu Val Asp Phe Leu Asn Pro Thr Ile Met Arg Gln Val Phe 
            900                 905                 910


Leu Gly Asn Pro Asp Lys Cys Pro Val Gln Gln Ala Ser Val Leu Cys 
        915                 920                 925


Asn Cys Val Leu Thr Leu Arg Glu Asn Ser Gln Glu Leu Ala Arg Leu 
    930                 935                 940


Glu Ala Phe Ser Arg Ala Tyr Arg Ser Ser Met Arg Glu Leu Val Gly 
945                 950                 955                 960


Ser Gly Arg Tyr Asp Thr Gln Glu Asp Phe Ser Val Val Leu Gln Pro 
                965                 970                 975


Phe Phe Gln Asn Ile Gln Leu Pro Val Leu Ala Asp Gly Leu Pro Asp 
            980                 985                 990


Thr Ser Phe Phe Ala Pro Asp Cys Ile His Pro Asn Gln Lys Phe His 
        995                 1000                1005


Ser Gln Leu Ala Arg Ala Leu Trp Thr Asn Met Leu Glu Pro Leu Gly 
    1010                1015                1020


Ser Lys Thr Glu Thr Leu Asp Leu Arg Ala Glu Met Pro Ile Thr Cys 
1025                1030                1035                1040


Pro Thr Gln Asn Glu Pro Phe Leu Arg Thr Pro Arg Asn Ser Asn Tyr 
                1045                1050                1055


Thr Tyr Pro Ile Lys Pro Ala Ile Glu Asn Trp Gly Ser Asp Phe Leu 
            1060                1065                1070


Cys Thr Glu Trp Lys Ala Ser Asn Ser Val Pro Thr Ser Val His Gln 
        1075                1080                1085


Leu Arg Pro Ala Asp Ile Lys Val Val Ala Ala Leu Gly Asp Ser Leu 
    1090                1095                1100


Thr Thr Ala Val Gly Ala Arg Pro Asn Asn Ser Ser Asp Leu Pro Thr 
1105                1110                1115                1120


Ser Trp Arg Gly Leu Ser Trp Ser Ile Gly Gly Asp Gly Asn Leu Glu 
                1125                1130                1135


Thr His Thr Thr Leu Pro Asn Ile Leu Lys Lys Phe Asn Pro Tyr Leu 
            1140                1145                1150


Leu Gly Phe Ser Thr Ser Thr Trp Glu Gly Thr Ala Gly Leu Asn Val 
        1155                1160                1165


Ala Ala Glu Gly Ala Arg Ala Arg Asp Met Pro Ala Gln Ala Trp Asp 
    1170                1175                1180


Leu Val Glu Arg Met Lys Asn Ser Pro Asp Ile Asn Leu Glu Lys Asp 
1185                1190                1195                1200


Trp Lys Leu Val Thr Leu Phe Ile Gly Val Asn Asp Leu Cys His Tyr 
                1205                1210                1215


Cys Glu Asn Pro Glu Ala His Leu Ala Thr Glu Tyr Val Gln His Ile 
            1220                1225                1230


Gln Gln Ala Leu Asp Ile Leu Ser Glu Glu Leu Pro Arg Ala Phe Val 
        1235                1240                1245


Asn Val Val Glu Val Met Glu Leu Ala Ser Leu Tyr Gln Gly Gln Gly 
    1250                1255                1260


Gly Lys Cys Ala Met Leu Ala Ala Gln Asn Asn Cys Thr Cys Leu Arg 
1265                1270                1275                1280


His Ser Gln Ser Ser Leu Glu Lys Gln Glu Leu Lys Lys Val Asn Trp 
                1285                1290                1295


Asn Leu Gln His Gly Ile Ser Ser Phe Ser Tyr Trp His Gln Tyr Thr 
            1300                1305                1310


Gln Arg Glu Asp Phe Ala Val Val Val Gln Pro Phe Phe Gln Asn Thr 
        1315                1320                1325


Leu Thr Pro Leu Asn Glu Arg Gly Asp Thr Asp Leu Thr Phe Phe Ser 
    1330                1335                1340


Glu Asp Cys Phe His Phe Ser Asp Arg Gly His Ala Glu Met Ala Ile 
1345                1350                1355                1360


Ala Leu Trp Asn Asn Met Leu Glu Pro Val Gly Arg Lys Thr Thr Ser 
                1365                1370                1375


Asn Asn Phe Thr His Ser Arg Ala Lys Leu Lys Cys Pro Ser Pro Glu 
            1380                1385                1390


Ser Pro Tyr Leu Tyr Thr Leu Arg Asn Ser Arg Leu Leu Pro Asp Gln 
        1395                1400                1405


Ala Glu Glu Ala Pro Glu Val Leu Tyr Trp Ala Val Pro Val Ala Ala 
    1410                1415                1420


Gly Val Gly Leu Val Val Gly Ile Ile Gly Thr Val Val Trp Arg Cys 
1425                1430                1435                1440


Arg Arg Gly Gly Arg Arg Glu Asp Pro Pro Met Ser Leu Arg Thr Val 
                1445                1450                1455


Ala Leu 



<210>  135
<211>  5298
<212>  DNA
<213>  Homo sapiens

<400>  135
atacagagca gcgagcactg aaggcttccc tctttcctta aacctgtcgg gttgtgggct     60

ctctcttttc ccctcttgct cctttctttt ctttttttct gtttttttaa accttccaag    120

gcaagttcat ggatactaag ctgatgtgtt tgttgttctt tttctccctg cctccgctcc    180

tagtgagtaa ccacactggc cgcatcaagg tggtctttac tccgagcatc tgtaaagtga    240

cctgcaccaa gggcagctgt cagaacagct gtgagaaggg gaacaccacc actctcatta    300

gtgagaatgg tcatgctgcc gacaccctga cggccacgaa cttccgagtg gtaatttgcc    360

atcttccatg tatgaatggt ggccagtgca gttcaaggga caaatgtcag tgccctccaa    420

atttcacagg aaaactttgt cagatcccag tccatggtgc cagcgtgcct aaactttatc    480

agcattccca gcagccaggc aaggcgttgg ggacgcatgt catccattca acacatacct    540

tgcctctgac cgtgactagc cagcaaggag tcaaagtgaa atttcctcct aacatagtca    600

atatccatgt gaaacatcct cctgaagctt ccgtccagat acatcaggtt tcaagaattg    660

atggcccaac aggccagaag acaaaagaag ctcaaccagg ccaatcccaa gtctcgtacc    720

aagggcttcc tgtccagaag acccagacca tacattccac atactcccac cagcaggtca    780

ttcctcacgt ctaccccgtg gctgctaaga cacagcttgg ccggtgcttc caggaaacca    840

ttgggtcaca gtgtggcaaa gcgctccctg gcctttcaaa gcaagaggac tgctgtggaa    900

ctgtgggtac ctcctggggc tttaacaaat gccagaaatg ccccaagaaa ccatcttatc    960

atggatacaa ccaaatgatg gaatgcctac cgggttataa gcgggttaac aacacctttt   1020

gccaagatat taatgaatgt cagctacaag gtgtatgccc taatggtgag tgtttgaata   1080

ccatgggcag ctatcgatgt acctgcaaaa taggatttgg gccggatcct accttttcaa   1140

gttgtgttcc tgatccccct gtgatctcgg aagagaaagg gccctgttac cgacttgtca   1200

gttctggaag acagtgtatg caccctctgt ctgttcacct caccaagcag ctctgctgtt   1260

gtagtgtggg caaggcctgg ggcccacact gtgagaaatg tccccttcca ggcacagctg   1320

cttttaagga aatctgtcct ggtggaatgg gttatacggt ttctggcgtt catagacgca   1380

ggccaatcca tcaccatgta ggtaaaggac ctgtatttgt caagccaaag aacactcaac   1440

ctgttgctaa aagtactcat cctccacctc tcccagccaa ggaagagcca gtggaggccc   1500

tgaccttctc ccgggaacac gggccaggag tggcggagcc agaagtggca actgcacccc   1560

ctgaaaagga aataccttca ttggatcaag agaaaaccaa acttgagcct ggtcaacccc   1620

agctgtctcc aggcatttcc actattcatc tgcatccaca gtttccaggt atagtgattg   1680

aaaaaacatc acctcctgtg cctgttgaag tagctcctga agcttctacg tctagtgcca   1740

gccaagtgat tgctcctact caagtgacag aaatcaatga atgtactgtg aaccctgata   1800

tctgtggagc aggacactgc attaacctac cagtgagata tacctgtata tgctacgagg   1860

gctacaggtt cagtgaacaa cagaggaaat gtgtggatat tgatgagtgt actcaggtcc   1920

aacacctctg ctcccagggc cgctgtgaaa acaccgaggg aagtttcttg tgcatttgcc   1980

cagcaggatt tatggccagt gaggagggta ctaactgcat agatgttgac gaatgcctga   2040

ggccggacgt ctgtggggag gggcactgtg tcaatactgt gggggccttc cggtgtgaat   2100

actgtgacag cgggtaccgc atgactcaga gaggccgttg tgaggatatt gatgaatgtt   2160

tgaatccaag cacttgtcca gatgagcagt gtgtgaattc tcctggatct taccagtgcg   2220

ttccctgcac agaaggattc cgaggctgga atggacagtg ccttgatgtg gacgagtgcc   2280

tggaaccaaa cgtctgcgca aatggtgatt gttccaacct tgaaggctcc tacatgtgtt   2340

catgccacaa aggctatacc cggactccgg accacaagca ctgtagagat attgatgaat   2400

gtcagcaagg gaatctatgt gtaaacgggc agtgcaaaaa taccgagggc tccttcaggt   2460

gcacctgtgg acaggggtac cagctgtcgg cagctaaaga ccagtgtgaa gacattgatg   2520

aatgccagca ccgtcatctc tgtgctcatg ggcagtgcag gaacactgag ggctcttttc   2580

aatgtgtgtg tgaccagggt tacagagcat ctgggcttgg agaccactgt gaagatatca   2640

atgaatgctt ggaggacaag agtgtttgcc agagaggaga ctgcattaat actgcagggt   2700

cctatgattg tacttgtccg gatggatttc agctagatga caataaaaca tgtcaagata   2760

ttaatgaatg tgaacatcca gggctctgtg gtccgcaagg ggagtgccta aacacagagg   2820

gttctttcca ttgtgtctgc cagcagggtt tctcaatctc tgcagatggc cgtacgtgtg   2880

aagatattga tgaatgtgta aacaacactg tttgtgacag tcacgggttt tgtgacaata   2940

cagctggctc cttccgctgc ctctgttatc agggctttca agccccacag gatgggcaag   3000

ggtgtgtgga tgtgaatgaa tgtgaactgc tcagtggggt gtgtggtgaa gccttctgtg   3060

aaaacgtgga agggtccttc ctgtgcgtgt gtgctgatga aaaccaagag tacagcccca   3120

tgactgggca gtgccgctcc cggacctcca cagatttaga tgtagatgta gatcaaccca   3180

aagaagaaaa gaaagaatgc tactataatc tcaatgacgc cagtctctgt gataatgtgt   3240

tggcccccaa tgtcacgaaa caagaatgct gctgtacatc aggcgcggga tggggagata   3300

actgcgaaat cttcccctgc ccggtcttgg gaactgctga gttcactgaa atgtgtccca   3360

aagggaaagg ttttgtgcct gctggagaat catcttctga agctggtggt gagaactata   3420

aagatgcaga tgaatgccta ctttttggac aagaaatctg caaaaatggt ttctgtttga   3480

acactcggcc tgggtatgaa tgctactgta agcaagggac gtactatgat cctgtgaaac   3540

tgcagtgctt tgatatggat gaatgtcaag accccagtag ttgtattgat ggccagtgtg   3600

ttaatacaga gggctcttac aactgcttct gtactcaccc catggtcctg gatgcgtcag   3660

aaaaaagatg tatacgaccg gctgagtcaa acgaacaaat agaagaaact gatgtctacc   3720

aagatttgtg ctgggaacat ctgagtgatg aatacgtgtg tagccggcct cttgtgggca   3780

agcagacaac gtacactgag tgctgctgtc tgtatggaga ggcctggggc atgcagtgtg   3840

ccctctgccc cctgaaggat tcagatgact atgctcagct gtgtaacatc cccgtgacgg   3900

gacgccggca gccatatgga cgggacgcct tggttgactt cagtgaacag tatactccag   3960

aagccgatcc ctacttcatc caagaccgtt ttctaaatag ctttgaggag ttacaggctg   4020

aggaatgcgg catcctcaat ggatgtgaaa atggtcgctg tgtgagggtc caggaaggtt   4080

acacctgcga ttgctttgat gggtatcact tggatacggc caagatgacc tgtgtcgatg   4140

taaatgaatg cgatgagttg aacaaccgga tgtctctctg caagaatgcc aagtgcatta   4200

acaccgatgg ttcctacaag tgtttgtgtc tgccaggcta cgtgccttct gacaagccaa   4260

actactgcac tccgttgaat accgccttga atttagagaa agacagtgac ctggagtgaa   4320

acagaatcta cataacctaa gcccatatac tctgcactgt gtaaaggaaa agggagaaat   4380

gtattatact tgagacattg cacctacccc ggaaggctgg aaatacagaa acagcatgga   4440

gttgcaagtc ctctgaagac aatgagagga tttaggatga gcccgatagg tgtggcagac   4500

caaatggaca tttctctaaa aaaccagtat atatagtctg ttcatatgta aaattcaatg   4560

gaagagaggt ggaacagtgc tgttatttta aacagaaggt tgtattatta tgttgttttg   4620

tttttttact attgcttgat taaatttggc atttaaatag tggtggaaat attttatata   4680

attttcattt tttggttgtg cagttccttg gctactgttt ttcttttact tcagtttttt   4740

aaaaatctca aatgaaaaag tcttcgatac aatattgtta agctgtatta taagtattgt   4800

tacacagggt tatgcaattc ccggcctgga gcatttttga aattcaaatt gtctgtcctg   4860

tggagcaggc agtgattttg ttccaaaact ttgtatacac atttggagaa aagtacttta   4920

tattttcagt gttttgtctg attttaatgt ccgttcttag ccaagctgct agcaggtgtt   4980

aattggatcc ctttccttca ctgaaatgga agagtttata agcttacgtt agtattgtaa   5040

tatgtaaagt aagcccaaca aaaattttta aaaatttgat gatccccaat atatctacca   5100

ttgtatgtta aataaatcac catttttgta gaaaaaattc tacctgagag taattgtcaa   5160

tgagtacatg tgtataagtt gtatcccact ctccccactt ttatcttttc cagtggtctt   5220

ctgttaatgt agtgtctttt acaagttaat cattaaattt gttagatctt gttatgggct   5280

aaaaaaaaaa aaaaaaaa                                                 5298


<210>  136
<211>  1396
<212>  PRT
<213>  Homo sapiens

<400>  136

Met Asp Thr Lys Leu Met Cys Leu Leu Phe Phe Phe Ser Leu Pro Pro 
1               5                   10                  15


Leu Leu Val Ser Asn His Thr Gly Arg Ile Lys Val Val Phe Thr Pro 
            20                  25                  30


Ser Ile Cys Lys Val Thr Cys Thr Lys Gly Ser Cys Gln Asn Ser Cys 
        35                  40                  45


Glu Lys Gly Asn Thr Thr Thr Leu Ile Ser Glu Asn Gly His Ala Ala 
    50                  55                  60


Asp Thr Leu Thr Ala Thr Asn Phe Arg Val Val Ile Cys His Leu Pro 
65                  70                  75                  80


Cys Met Asn Gly Gly Gln Cys Ser Ser Arg Asp Lys Cys Gln Cys Pro 
                85                  90                  95


Pro Asn Phe Thr Gly Lys Leu Cys Gln Ile Pro Val His Gly Ala Ser 
            100                 105                 110


Val Pro Lys Leu Tyr Gln His Ser Gln Gln Pro Gly Lys Ala Leu Gly 
        115                 120                 125


Thr His Val Ile His Ser Thr His Thr Leu Pro Leu Thr Val Thr Ser 
    130                 135                 140


Gln Gln Gly Val Lys Val Lys Phe Pro Pro Asn Ile Val Asn Ile His 
145                 150                 155                 160


Val Lys His Pro Pro Glu Ala Ser Val Gln Ile His Gln Val Ser Arg 
                165                 170                 175


Ile Asp Gly Pro Thr Gly Gln Lys Thr Lys Glu Ala Gln Pro Gly Gln 
            180                 185                 190


Ser Gln Val Ser Tyr Gln Gly Leu Pro Val Gln Lys Thr Gln Thr Ile 
        195                 200                 205


His Ser Thr Tyr Ser His Gln Gln Val Ile Pro His Val Tyr Pro Val 
    210                 215                 220


Ala Ala Lys Thr Gln Leu Gly Arg Cys Phe Gln Glu Thr Ile Gly Ser 
225                 230                 235                 240


Gln Cys Gly Lys Ala Leu Pro Gly Leu Ser Lys Gln Glu Asp Cys Cys 
                245                 250                 255


Gly Thr Val Gly Thr Ser Trp Gly Phe Asn Lys Cys Gln Lys Cys Pro 
            260                 265                 270


Lys Lys Pro Ser Tyr His Gly Tyr Asn Gln Met Met Glu Cys Leu Pro 
        275                 280                 285


Gly Tyr Lys Arg Val Asn Asn Thr Phe Cys Gln Asp Ile Asn Glu Cys 
    290                 295                 300


Gln Leu Gln Gly Val Cys Pro Asn Gly Glu Cys Leu Asn Thr Met Gly 
305                 310                 315                 320


Ser Tyr Arg Cys Thr Cys Lys Ile Gly Phe Gly Pro Asp Pro Thr Phe 
                325                 330                 335


Ser Ser Cys Val Pro Asp Pro Pro Val Ile Ser Glu Glu Lys Gly Pro 
            340                 345                 350


Cys Tyr Arg Leu Val Ser Ser Gly Arg Gln Cys Met His Pro Leu Ser 
        355                 360                 365


Val His Leu Thr Lys Gln Leu Cys Cys Cys Ser Val Gly Lys Ala Trp 
    370                 375                 380


Gly Pro His Cys Glu Lys Cys Pro Leu Pro Gly Thr Ala Ala Phe Lys 
385                 390                 395                 400


Glu Ile Cys Pro Gly Gly Met Gly Tyr Thr Val Ser Gly Val His Arg 
                405                 410                 415


Arg Arg Pro Ile His His His Val Gly Lys Gly Pro Val Phe Val Lys 
            420                 425                 430


Pro Lys Asn Thr Gln Pro Val Ala Lys Ser Thr His Pro Pro Pro Leu 
        435                 440                 445


Pro Ala Lys Glu Glu Pro Val Glu Ala Leu Thr Phe Ser Arg Glu His 
    450                 455                 460


Gly Pro Gly Val Ala Glu Pro Glu Val Ala Thr Ala Pro Pro Glu Lys 
465                 470                 475                 480


Glu Ile Pro Ser Leu Asp Gln Glu Lys Thr Lys Leu Glu Pro Gly Gln 
                485                 490                 495


Pro Gln Leu Ser Pro Gly Ile Ser Thr Ile His Leu His Pro Gln Phe 
            500                 505                 510


Pro Gly Ile Val Ile Glu Lys Thr Ser Pro Pro Val Pro Val Glu Val 
        515                 520                 525


Ala Pro Glu Ala Ser Thr Ser Ser Ala Ser Gln Val Ile Ala Pro Thr 
    530                 535                 540


Gln Val Thr Glu Ile Asn Glu Cys Thr Val Asn Pro Asp Ile Cys Gly 
545                 550                 555                 560


Ala Gly His Cys Ile Asn Leu Pro Val Arg Tyr Thr Cys Ile Cys Tyr 
                565                 570                 575


Glu Gly Tyr Arg Phe Ser Glu Gln Gln Arg Lys Cys Val Asp Ile Asp 
            580                 585                 590


Glu Cys Thr Gln Val Gln His Leu Cys Ser Gln Gly Arg Cys Glu Asn 
        595                 600                 605


Thr Glu Gly Ser Phe Leu Cys Ile Cys Pro Ala Gly Phe Met Ala Ser 
    610                 615                 620


Glu Glu Gly Thr Asn Cys Ile Asp Val Asp Glu Cys Leu Arg Pro Asp 
625                 630                 635                 640


Val Cys Gly Glu Gly His Cys Val Asn Thr Val Gly Ala Phe Arg Cys 
                645                 650                 655


Glu Tyr Cys Asp Ser Gly Tyr Arg Met Thr Gln Arg Gly Arg Cys Glu 
            660                 665                 670


Asp Ile Asp Glu Cys Leu Asn Pro Ser Thr Cys Pro Asp Glu Gln Cys 
        675                 680                 685


Val Asn Ser Pro Gly Ser Tyr Gln Cys Val Pro Cys Thr Glu Gly Phe 
    690                 695                 700


Arg Gly Trp Asn Gly Gln Cys Leu Asp Val Asp Glu Cys Leu Glu Pro 
705                 710                 715                 720


Asn Val Cys Ala Asn Gly Asp Cys Ser Asn Leu Glu Gly Ser Tyr Met 
                725                 730                 735


Cys Ser Cys His Lys Gly Tyr Thr Arg Thr Pro Asp His Lys His Cys 
            740                 745                 750


Arg Asp Ile Asp Glu Cys Gln Gln Gly Asn Leu Cys Val Asn Gly Gln 
        755                 760                 765


Cys Lys Asn Thr Glu Gly Ser Phe Arg Cys Thr Cys Gly Gln Gly Tyr 
    770                 775                 780


Gln Leu Ser Ala Ala Lys Asp Gln Cys Glu Asp Ile Asp Glu Cys Gln 
785                 790                 795                 800


His Arg His Leu Cys Ala His Gly Gln Cys Arg Asn Thr Glu Gly Ser 
                805                 810                 815


Phe Gln Cys Val Cys Asp Gln Gly Tyr Arg Ala Ser Gly Leu Gly Asp 
            820                 825                 830


His Cys Glu Asp Ile Asn Glu Cys Leu Glu Asp Lys Ser Val Cys Gln 
        835                 840                 845


Arg Gly Asp Cys Ile Asn Thr Ala Gly Ser Tyr Asp Cys Thr Cys Pro 
    850                 855                 860


Asp Gly Phe Gln Leu Asp Asp Asn Lys Thr Cys Gln Asp Ile Asn Glu 
865                 870                 875                 880


Cys Glu His Pro Gly Leu Cys Gly Pro Gln Gly Glu Cys Leu Asn Thr 
                885                 890                 895


Glu Gly Ser Phe His Cys Val Cys Gln Gln Gly Phe Ser Ile Ser Ala 
            900                 905                 910


Asp Gly Arg Thr Cys Glu Asp Ile Asp Glu Cys Val Asn Asn Thr Val 
        915                 920                 925


Cys Asp Ser His Gly Phe Cys Asp Asn Thr Ala Gly Ser Phe Arg Cys 
    930                 935                 940


Leu Cys Tyr Gln Gly Phe Gln Ala Pro Gln Asp Gly Gln Gly Cys Val 
945                 950                 955                 960


Asp Val Asn Glu Cys Glu Leu Leu Ser Gly Val Cys Gly Glu Ala Phe 
                965                 970                 975


Cys Glu Asn Val Glu Gly Ser Phe Leu Cys Val Cys Ala Asp Glu Asn 
            980                 985                 990


Gln Glu Tyr Ser Pro Met Thr Gly Gln Cys Arg Ser Arg Thr Ser Thr 
        995                 1000                1005


Asp Leu Asp Val Asp Val Asp Gln Pro Lys Glu Glu Lys Lys Glu Cys 
    1010                1015                1020


Tyr Tyr Asn Leu Asn Asp Ala Ser Leu Cys Asp Asn Val Leu Ala Pro 
1025                1030                1035                1040


Asn Val Thr Lys Gln Glu Cys Cys Cys Thr Ser Gly Ala Gly Trp Gly 
                1045                1050                1055


Asp Asn Cys Glu Ile Phe Pro Cys Pro Val Leu Gly Thr Ala Glu Phe 
            1060                1065                1070


Thr Glu Met Cys Pro Lys Gly Lys Gly Phe Val Pro Ala Gly Glu Ser 
        1075                1080                1085


Ser Ser Glu Ala Gly Gly Glu Asn Tyr Lys Asp Ala Asp Glu Cys Leu 
    1090                1095                1100


Leu Phe Gly Gln Glu Ile Cys Lys Asn Gly Phe Cys Leu Asn Thr Arg 
1105                1110                1115                1120


Pro Gly Tyr Glu Cys Tyr Cys Lys Gln Gly Thr Tyr Tyr Asp Pro Val 
                1125                1130                1135


Lys Leu Gln Cys Phe Asp Met Asp Glu Cys Gln Asp Pro Ser Ser Cys 
            1140                1145                1150


Ile Asp Gly Gln Cys Val Asn Thr Glu Gly Ser Tyr Asn Cys Phe Cys 
        1155                1160                1165


Thr His Pro Met Val Leu Asp Ala Ser Glu Lys Arg Cys Ile Arg Pro 
    1170                1175                1180


Ala Glu Ser Asn Glu Gln Ile Glu Glu Thr Asp Val Tyr Gln Asp Leu 
1185                1190                1195                1200


Cys Trp Glu His Leu Ser Asp Glu Tyr Val Cys Ser Arg Pro Leu Val 
                1205                1210                1215


Gly Lys Gln Thr Thr Tyr Thr Glu Cys Cys Cys Leu Tyr Gly Glu Ala 
            1220                1225                1230


Trp Gly Met Gln Cys Ala Leu Cys Pro Leu Lys Asp Ser Asp Asp Tyr 
        1235                1240                1245


Ala Gln Leu Cys Asn Ile Pro Val Thr Gly Arg Arg Gln Pro Tyr Gly 
    1250                1255                1260


Arg Asp Ala Leu Val Asp Phe Ser Glu Gln Tyr Thr Pro Glu Ala Asp 
1265                1270                1275                1280


Pro Tyr Phe Ile Gln Asp Arg Phe Leu Asn Ser Phe Glu Glu Leu Gln 
                1285                1290                1295


Ala Glu Glu Cys Gly Ile Leu Asn Gly Cys Glu Asn Gly Arg Cys Val 
            1300                1305                1310


Arg Val Gln Glu Gly Tyr Thr Cys Asp Cys Phe Asp Gly Tyr His Leu 
        1315                1320                1325


Asp Thr Ala Lys Met Thr Cys Val Asp Val Asn Glu Cys Asp Glu Leu 
    1330                1335                1340


Asn Asn Arg Met Ser Leu Cys Lys Asn Ala Lys Cys Ile Asn Thr Asp 
1345                1350                1355                1360


Gly Ser Tyr Lys Cys Leu Cys Leu Pro Gly Tyr Val Pro Ser Asp Lys 
                1365                1370                1375


Pro Asn Tyr Cys Thr Pro Leu Asn Thr Ala Leu Asn Leu Glu Lys Asp 
            1380                1385                1390


Ser Asp Leu Glu 
        1395


<210>  137
<211>  6148
<212>  DNA
<213>  Homo sapiens

<400>  137
atggcggggg cctggctcag gtgggggctc ctgctctggg cagggctcct cgcgtcctcg     60

gcgcacggcc ggctgcggag gatcacctac gtggtgcacc cgggccccgg cctggcagcc    120

ggcgccttgc ccctgagcgg gcccccgcgt tcgcggacat tcaacgtcgc gctcaacgcc    180

aggtacagcc gcagctcggc ggctgccggc gcccccagcc gtgcctcccc cggggtcccc    240

tcggagagga cccggcgcac gagcaagccg ggcggcgcgg ccctgcaggg gctcagaccg    300

ccgccgccgc cgccgccgga gcctgcgcgt cccgcggtcc ccggcgggca gctccacccc    360

aatcccggcg gccacccggc agccgccccg ttcaccaaac aaggcaggca agttgtgcgc    420

tccaaggtgc cgcaggagac ccagagcggc ggaggctcta ggctgcaggt tcaccagaag    480

cagcagctgc agggggtcaa tgtctgtgga gggcggtgct gtcatggctg gagtaaggcc    540

cctggctccc agaggtgcac caaacctagc tgtgttccgc catgtcagaa tggagggatg    600

tgtctccggc cacaactctg tgtgtgtaaa ccagggacca agggcaaagc ctgtgaaaca    660

atagctgccc aggacacctc gtcaccagtc tttggagggc agagtcctgg ggctgcttcc    720

tcgtggggcc ctcctgagca agcagcaaag catacttcat ctaagaaggc agacactcta    780

ccaagagtca gccctgtggc ccagatgacc ttaaccctca agccgaagcc ttcagtggga    840

ctcccccagc agatacattc tcaagtgact cctctttctt cccagagtgt ggtgattcac    900

catggccaga cccaggaata cgtgctcaag cccaagtact ttccagccca gaaggggatt    960

tcaggagagc agtccactga aggttctttc cctttaagat atgtgcagga tcaagttgcg   1020

gcaccttttc agctgagtaa ccacactggc cgcatcaagg tggtctttac tccgagcatc   1080

tgtaaagtga cctgcaccaa gggcagctgt cagaacagct gtgagaaggg gaacaccacc   1140

actctcatta gtgagaatgg tcatgctgcc gacaccctga cggccacgaa cttccgagtg   1200

gtaatttgcc atcttccatg tatgaatggt ggccagtgca gttcaaggga caaatgtcag   1260

tgccctccaa atttcacagg aaaactttgt cagatcccag tccatggtgc cagcgtgcct   1320

aaactttatc agcattccca gcagccaggc aaggcgttgg ggacgcatgt catccattca   1380

acacatacct tgcctctgac cgtgactagc cagcaaggag tcaaagtgaa atttcctcct   1440

aacatagtca atatccatgt gaaacatcct cctgaagctt ccgtccagat acatcaggtt   1500

tcaagaattg atggcccaac aggccagaag acaaaagaag ctcaaccagg ccaatcccaa   1560

gtctcgtacc aagggcttcc tgtccagaag acccagacca tacattccac atactcccac   1620

cagcaggtca ttcctcacgt ctaccccgtg gctgctaaga cacagcttgg ccggtgcttc   1680

caggaaacca ttgggtcaca gtgtggcaaa gcgctccctg gcctttcaaa gcaagaggac   1740

tgctgtggaa ctgtgggtac ctcctggggc tttaacaaat gccagaaatg ccccaagaaa   1800

ccatcttatc atggatacaa ccaaatgatg gaatgcctac cgggttataa gcgggttaac   1860

aacacctttt gccaagatat taatgaatgt cagctacaag gtgtatgccc taatggtgag   1920

tgtttgaata ccatgggcag ctatcgatgt acctgcaaaa taggatttgg gccggatcct   1980

accttttcaa gttgtgttcc tgatccccct gtgatctcgg aagagaaagg gccctgttac   2040

cgacttgtca gttctggaag acagtgtatg caccctctgt ctgttcacct caccaagcag   2100

ctctgctgtt gtagtgtggg caaggcctgg ggcccacact gtgagaaatg tccccttcca   2160

ggcacagctg cttttaagga aatctgtcct ggtggaatgg gttatacggt ttctggcgtt   2220

catagacgca ggccaatcca tcaccatgta ggtaaaggac ctgtatttgt caagccaaag   2280

aacactcaac ctgttgctaa aagtactcat cctccacctc tcccagccaa ggaagagcca   2340

gtggaggccc tgaccttctc ccgggaacac gggccaggag tggcggagcc agaagtggca   2400

actgcacccc ctgaaaagga aataccttca ttggatcaag agaaaaccaa acttgagcct   2460

ggtcaacccc agctgtctcc aggcatttcc actattcatc tgcatccaca gtttccaggt   2520

atagtgattg aaaaaacatc acctcctgtg cctgttgaag tagctcctga agcttctacg   2580

tctagtgcca gccaagtgat tgctcctact caagtgacag aaatcaatga atgtactgtg   2640

aaccctgata tctgtggagc aggacactgc attaacctac cagtgagata tacctgtata   2700

tgctacgagg gctacaggtt cagtgaacaa cagaggaaat gtgtggatat tgatgagtgt   2760

actcaggtcc aacacctctg ctcccagggc cgctgtgaaa acaccgaggg aagtttcttg   2820

tgcatttgcc cagcaggatt tatggccagt gaggagggta ctaactgcat agatgttgac   2880

gaatgcctga ggccggacgt ctgtggggag gggcactgtg tcaatactgt gggggccttc   2940

cggtgtgaat actgtgacag cgggtaccgc atgactcaga gaggccgttg tgaggatatt   3000

gatgaatgtt tgaatccaag cacttgtcca gatgagcagt gtgtgaattc tcctggatct   3060

taccagtgcg ttccctgcac agaaggattc cgaggctgga atggacagtg ccttgatgtg   3120

gacgagtgcc tggaaccaaa cgtctgcgca aatggtgatt gttccaacct tgaaggctcc   3180

tacatgtgtt catgccacaa aggctatacc cggactccgg accacaagca ctgtagagat   3240

attgatgaat gtcagcaagg gaatctatgt gtaaacgggc agtgcaaaaa taccgagggc   3300

tccttcaggt gcacctgtgg acaggggtac cagctgtcgg cagctaaaga ccagtgtgaa   3360

gacattgatg aatgccagca ccgtcatctc tgtgctcatg ggcagtgcag gaacactgag   3420

ggctcttttc aatgtgtgtg tgaccagggt tacagagcat ctgggcttgg agaccactgt   3480

gaagatatca atgaatgctt ggaggacaag agtgtttgcc agagaggaga ctgcattaat   3540

actgcagggt cctatgattg tacttgtccg gatggatttc agctagatga caataaaaca   3600

tgtcaagata ttaatgaatg tgaacatcca gggctctgtg gtccgcaagg ggagtgccta   3660

aacacagagg gttctttcca ttgtgtctgc cagcagggtt tctcaatctc tgcagatggc   3720

cgtacgtgtg aagatattga tgaatgtgta aacaacactg tttgtgacag tcacgggttt   3780

tgtgacaata cagctggctc cttccgctgc ctctgttatc agggctttca agccccacag   3840

gatgggcaag ggtgtgtgga tgtgaatgaa tgtgaactgc tcagtggggt gtgtggtgaa   3900

gccttctgtg aaaacgtgga agggtccttc ctgtgcgtgt gtgctgatga aaaccaagag   3960

tacagcccca tgactgggca gtgccgctcc cggacctcca cagatttaga tgtagatgta   4020

gatcaaccca aagaagaaaa gaaagaatgc tactataatc tcaatgacgc cagtctctgt   4080

gataatgtgt tggcccccaa tgtcacgaaa caagaatgct gctgtacatc aggcgcggga   4140

tggggagata actgcgaaat cttcccctgc ccggtcttgg gaactgctga gttcactgaa   4200

atgtgtccca aagggaaagg ttttgtgcct gctggagaat catcttctga agctggtggt   4260

gagaactata aagatgcaga tgaatgccta ctttttggac aagaaatctg caaaaatggt   4320

ttctgtttga acactcggcc tgggtatgaa tgctactgta agcaagggac gtactatgat   4380

cctgtgaaac tgcagtgctt tgatatggat gaatgtcaag accccagtag ttgtattgat   4440

ggccagtgtg ttaatacaga gggctcttac aactgcttct gtactcaccc catggtcctg   4500

gatgcgtcag aaaaaagatg tatacgaccg gctgagtcaa acgaacaaat agaagaaact   4560

gatgtctacc aagatttgtg ctgggaacat ctgagtgatg aatacgtgtg tagccggcct   4620

cttgtgggca agcagacaac gtacactgag tgctgctgtc tgtatggaga ggcctggggc   4680

atgcagtgtg ccctctgccc cctgaaggat tcagatgact atgctcagct gtgtaacatc   4740

cccgtgacgg gacgccggca gccatatgga cgggacgcct tggttgactt cagtgaacag   4800

tatactccag aagccgatcc ctacttcatc caagaccgtt ttctaaatag ctttgaggag   4860

ttacaggctg aggaatgcgg catcctcaat ggatgtgaaa atggtcgctg tgtgagggtc   4920

caggaaggtt acacctgcga ttgctttgat gggtatcact tggatacggc caagatgacc   4980

tgtgtcgatg taaatgaatg cgatgagttg aacaaccgga tgtctctctg caagaatgcc   5040

aagtgcatta acaccgatgg ttcctacaag tgtttgtgtc tgccaggcta cgtgccttct   5100

gacaagccaa actactgcac tccgttgaat accgccttga atttagagaa agacagtgac   5160

ctggagtgaa acagaatcta cataacctaa gcccatatac tctgcactgt gtaaaggaaa   5220

agggagaaat gtattatact tgagacattg cacctacccc ggaaggctgg aaatacagaa   5280

acagcatgga gttgcaagtc ctctgaagac aatgagagga tttaggatga gcccgatagg   5340

tgtggcagac caaatggaca tttctctaaa aaaccagtat atatagtctg ttcatatgta   5400

aaattcaatg gaagagaggt ggaacagtgc tgttatttta aacagaaggt tgtattatta   5460

tgttgttttg tttttttact attgcttgat taaatttggc atttaaatag tggtggaaat   5520

attttatata attttcattt tttggttgtg cagttccttg gctactgttt ttcttttact   5580

tcagtttttt aaaaatctca aatgaaaaag tcttcgatac aatattgtta agctgtatta   5640

taagtattgt tacacagggt tatgcaattc ccggcctgga gcatttttga aattcaaatt   5700

gtctgtcctg tggagcaggc agtgattttg ttccaaaact ttgtatacac atttggagaa   5760

aagtacttta tattttcagt gttttgtctg attttaatgt ccgttcttag ccaagctgct   5820

agcaggtgtt aattggatcc ctttccttca ctgaaatgga agagtttata agcttacgtt   5880

agtattgtaa tatgtaaagt aagcccaaca aaaattttta aaaatttgat gatccccaat   5940

atatctacca ttgtatgtta aataaatcac catttttgta gaaaaaattc tacctgagag   6000

taattgtcaa tgagtacatg tgtataagtt gtatcccact ctccccactt ttatcttttc   6060

cagtggtctt ctgttaatgt agtgtctttt acaagttaat cattaaattt gttagatctt   6120

gttatgggct aaaaaaaaaa aaaaaaaa                                      6148


<210>  138
<211>  1722
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Ala Gly Ala Trp Leu Arg Trp Gly Leu Leu Leu Trp Ala Gly Leu 
1               5                   10                  15


Leu Ala Ser Ser Ala His Gly Arg Leu Arg Arg Ile Thr Tyr Val Val 
            20                  25                  30


His Pro Gly Pro Gly Leu Ala Ala Gly Ala Leu Pro Leu Ser Gly Pro 
        35                  40                  45


Pro Arg Ser Arg Thr Phe Asn Val Ala Leu Asn Ala Arg Tyr Ser Arg 
    50                  55                  60


Ser Ser Ala Ala Ala Gly Ala Pro Ser Arg Ala Ser Pro Gly Val Pro 
65                  70                  75                  80


Ser Glu Arg Thr Arg Arg Thr Ser Lys Pro Gly Gly Ala Ala Leu Gln 
                85                  90                  95


Gly Leu Arg Pro Pro Pro Pro Pro Pro Pro Glu Pro Ala Arg Pro Ala 
            100                 105                 110


Val Pro Gly Gly Gln Leu His Pro Asn Pro Gly Gly His Pro Ala Ala 
        115                 120                 125


Ala Pro Phe Thr Lys Gln Gly Arg Gln Val Val Arg Ser Lys Val Pro 
    130                 135                 140


Gln Glu Thr Gln Ser Gly Gly Gly Ser Arg Leu Gln Val His Gln Lys 
145                 150                 155                 160


Gln Gln Leu Gln Gly Val Asn Val Cys Gly Gly Arg Cys Cys His Gly 
                165                 170                 175


Trp Ser Lys Ala Pro Gly Ser Gln Arg Cys Thr Lys Pro Ser Cys Val 
            180                 185                 190


Pro Pro Cys Gln Asn Gly Gly Met Cys Leu Arg Pro Gln Leu Cys Val 
        195                 200                 205


Cys Lys Pro Gly Thr Lys Gly Lys Ala Cys Glu Thr Ile Ala Ala Gln 
    210                 215                 220


Asp Thr Ser Ser Pro Val Phe Gly Gly Gln Ser Pro Gly Ala Ala Ser 
225                 230                 235                 240


Ser Trp Gly Pro Pro Glu Gln Ala Ala Lys His Thr Ser Ser Lys Lys 
                245                 250                 255


Ala Asp Thr Leu Pro Arg Val Ser Pro Val Ala Gln Met Thr Leu Thr 
            260                 265                 270


Leu Lys Pro Lys Pro Ser Val Gly Leu Pro Gln Gln Ile His Ser Gln 
        275                 280                 285


Val Thr Pro Leu Ser Ser Gln Ser Val Val Ile His His Gly Gln Thr 
    290                 295                 300


Gln Glu Tyr Val Leu Lys Pro Lys Tyr Phe Pro Ala Gln Lys Gly Ile 
305                 310                 315                 320


Ser Gly Glu Gln Ser Thr Glu Gly Ser Phe Pro Leu Arg Tyr Val Gln 
                325                 330                 335


Asp Gln Val Ala Ala Pro Phe Gln Leu Ser Asn His Thr Gly Arg Ile 
            340                 345                 350


Lys Val Val Phe Thr Pro Ser Ile Cys Lys Val Thr Cys Thr Lys Gly 
        355                 360                 365


Ser Cys Gln Asn Ser Cys Glu Lys Gly Asn Thr Thr Thr Leu Ile Ser 
    370                 375                 380


Glu Asn Gly His Ala Ala Asp Thr Leu Thr Ala Thr Asn Phe Arg Val 
385                 390                 395                 400


Val Ile Cys His Leu Pro Cys Met Asn Gly Gly Gln Cys Ser Ser Arg 
                405                 410                 415


Asp Lys Cys Gln Cys Pro Pro Asn Phe Thr Gly Lys Leu Cys Gln Ile 
            420                 425                 430


Pro Val His Gly Ala Ser Val Pro Lys Leu Tyr Gln His Ser Gln Gln 
        435                 440                 445


Pro Gly Lys Ala Leu Gly Thr His Val Ile His Ser Thr His Thr Leu 
    450                 455                 460


Pro Leu Thr Val Thr Ser Gln Gln Gly Val Lys Val Lys Phe Pro Pro 
465                 470                 475                 480


Asn Ile Val Asn Ile His Val Lys His Pro Pro Glu Ala Ser Val Gln 
                485                 490                 495


Ile His Gln Val Ser Arg Ile Asp Gly Pro Thr Gly Gln Lys Thr Lys 
            500                 505                 510


Glu Ala Gln Pro Gly Gln Ser Gln Val Ser Tyr Gln Gly Leu Pro Val 
        515                 520                 525


Gln Lys Thr Gln Thr Ile His Ser Thr Tyr Ser His Gln Gln Val Ile 
    530                 535                 540


Pro His Val Tyr Pro Val Ala Ala Lys Thr Gln Leu Gly Arg Cys Phe 
545                 550                 555                 560


Gln Glu Thr Ile Gly Ser Gln Cys Gly Lys Ala Leu Pro Gly Leu Ser 
                565                 570                 575


Lys Gln Glu Asp Cys Cys Gly Thr Val Gly Thr Ser Trp Gly Phe Asn 
            580                 585                 590


Lys Cys Gln Lys Cys Pro Lys Lys Pro Ser Tyr His Gly Tyr Asn Gln 
        595                 600                 605


Met Met Glu Cys Leu Pro Gly Tyr Lys Arg Val Asn Asn Thr Phe Cys 
    610                 615                 620


Gln Asp Ile Asn Glu Cys Gln Leu Gln Gly Val Cys Pro Asn Gly Glu 
625                 630                 635                 640


Cys Leu Asn Thr Met Gly Ser Tyr Arg Cys Thr Cys Lys Ile Gly Phe 
                645                 650                 655


Gly Pro Asp Pro Thr Phe Ser Ser Cys Val Pro Asp Pro Pro Val Ile 
            660                 665                 670


Ser Glu Glu Lys Gly Pro Cys Tyr Arg Leu Val Ser Ser Gly Arg Gln 
        675                 680                 685


Cys Met His Pro Leu Ser Val His Leu Thr Lys Gln Leu Cys Cys Cys 
    690                 695                 700


Ser Val Gly Lys Ala Trp Gly Pro His Cys Glu Lys Cys Pro Leu Pro 
705                 710                 715                 720


Gly Thr Ala Ala Phe Lys Glu Ile Cys Pro Gly Gly Met Gly Tyr Thr 
                725                 730                 735


Val Ser Gly Val His Arg Arg Arg Pro Ile His His His Val Gly Lys 
            740                 745                 750


Gly Pro Val Phe Val Lys Pro Lys Asn Thr Gln Pro Val Ala Lys Ser 
        755                 760                 765


Thr His Pro Pro Pro Leu Pro Ala Lys Glu Glu Pro Val Glu Ala Leu 
    770                 775                 780


Thr Phe Ser Arg Glu His Gly Pro Gly Val Ala Glu Pro Glu Val Ala 
785                 790                 795                 800


Thr Ala Pro Pro Glu Lys Glu Ile Pro Ser Leu Asp Gln Glu Lys Thr 
                805                 810                 815


Lys Leu Glu Pro Gly Gln Pro Gln Leu Ser Pro Gly Ile Ser Thr Ile 
            820                 825                 830


His Leu His Pro Gln Phe Pro Gly Ile Val Ile Glu Lys Thr Ser Pro 
        835                 840                 845


Pro Val Pro Val Glu Val Ala Pro Glu Ala Ser Thr Ser Ser Ala Ser 
    850                 855                 860


Gln Val Ile Ala Pro Thr Gln Val Thr Glu Ile Asn Glu Cys Thr Val 
865                 870                 875                 880


Asn Pro Asp Ile Cys Gly Ala Gly His Cys Ile Asn Leu Pro Val Arg 
                885                 890                 895


Tyr Thr Cys Ile Cys Tyr Glu Gly Tyr Arg Phe Ser Glu Gln Gln Arg 
            900                 905                 910


Lys Cys Val Asp Ile Asp Glu Cys Thr Gln Val Gln His Leu Cys Ser 
        915                 920                 925


Gln Gly Arg Cys Glu Asn Thr Glu Gly Ser Phe Leu Cys Ile Cys Pro 
    930                 935                 940


Ala Gly Phe Met Ala Ser Glu Glu Gly Thr Asn Cys Ile Asp Val Asp 
945                 950                 955                 960


Glu Cys Leu Arg Pro Asp Val Cys Gly Glu Gly His Cys Val Asn Thr 
                965                 970                 975


Val Gly Ala Phe Arg Cys Glu Tyr Cys Asp Ser Gly Tyr Arg Met Thr 
            980                 985                 990


Gln Arg Gly Arg Cys Glu Asp Ile Asp Glu Cys Leu Asn Pro Ser Thr 
        995                 1000                1005


Cys Pro Asp Glu Gln Cys Val Asn Ser Pro Gly Ser Tyr Gln Cys Val 
    1010                1015                1020


Pro Cys Thr Glu Gly Phe Arg Gly Trp Asn Gly Gln Cys Leu Asp Val 
1025                1030                1035                1040


Asp Glu Cys Leu Glu Pro Asn Val Cys Ala Asn Gly Asp Cys Ser Asn 
                1045                1050                1055


Leu Glu Gly Ser Tyr Met Cys Ser Cys His Lys Gly Tyr Thr Arg Thr 
            1060                1065                1070


Pro Asp His Lys His Cys Arg Asp Ile Asp Glu Cys Gln Gln Gly Asn 
        1075                1080                1085


Leu Cys Val Asn Gly Gln Cys Lys Asn Thr Glu Gly Ser Phe Arg Cys 
    1090                1095                1100


Thr Cys Gly Gln Gly Tyr Gln Leu Ser Ala Ala Lys Asp Gln Cys Glu 
1105                1110                1115                1120


Asp Ile Asp Glu Cys Gln His Arg His Leu Cys Ala His Gly Gln Cys 
                1125                1130                1135


Arg Asn Thr Glu Gly Ser Phe Gln Cys Val Cys Asp Gln Gly Tyr Arg 
            1140                1145                1150


Ala Ser Gly Leu Gly Asp His Cys Glu Asp Ile Asn Glu Cys Leu Glu 
        1155                1160                1165


Asp Lys Ser Val Cys Gln Arg Gly Asp Cys Ile Asn Thr Ala Gly Ser 
    1170                1175                1180


Tyr Asp Cys Thr Cys Pro Asp Gly Phe Gln Leu Asp Asp Asn Lys Thr 
1185                1190                1195                1200


Cys Gln Asp Ile Asn Glu Cys Glu His Pro Gly Leu Cys Gly Pro Gln 
                1205                1210                1215


Gly Glu Cys Leu Asn Thr Glu Gly Ser Phe His Cys Val Cys Gln Gln 
            1220                1225                1230


Gly Phe Ser Ile Ser Ala Asp Gly Arg Thr Cys Glu Asp Ile Asp Glu 
        1235                1240                1245


Cys Val Asn Asn Thr Val Cys Asp Ser His Gly Phe Cys Asp Asn Thr 
    1250                1255                1260


Ala Gly Ser Phe Arg Cys Leu Cys Tyr Gln Gly Phe Gln Ala Pro Gln 
1265                1270                1275                1280


Asp Gly Gln Gly Cys Val Asp Val Asn Glu Cys Glu Leu Leu Ser Gly 
                1285                1290                1295


Val Cys Gly Glu Ala Phe Cys Glu Asn Val Glu Gly Ser Phe Leu Cys 
            1300                1305                1310


Val Cys Ala Asp Glu Asn Gln Glu Tyr Ser Pro Met Thr Gly Gln Cys 
        1315                1320                1325


Arg Ser Arg Thr Ser Thr Asp Leu Asp Val Asp Val Asp Gln Pro Lys 
    1330                1335                1340


Glu Glu Lys Lys Glu Cys Tyr Tyr Asn Leu Asn Asp Ala Ser Leu Cys 
1345                1350                1355                1360


Asp Asn Val Leu Ala Pro Asn Val Thr Lys Gln Glu Cys Cys Cys Thr 
                1365                1370                1375


Ser Gly Ala Gly Trp Gly Asp Asn Cys Glu Ile Phe Pro Cys Pro Val 
            1380                1385                1390


Leu Gly Thr Ala Glu Phe Thr Glu Met Cys Pro Lys Gly Lys Gly Phe 
        1395                1400                1405


Val Pro Ala Gly Glu Ser Ser Ser Glu Ala Gly Gly Glu Asn Tyr Lys 
    1410                1415                1420


Asp Ala Asp Glu Cys Leu Leu Phe Gly Gln Glu Ile Cys Lys Asn Gly 
1425                1430                1435                1440


Phe Cys Leu Asn Thr Arg Pro Gly Tyr Glu Cys Tyr Cys Lys Gln Gly 
                1445                1450                1455


Thr Tyr Tyr Asp Pro Val Lys Leu Gln Cys Phe Asp Met Asp Glu Cys 
            1460                1465                1470


Gln Asp Pro Ser Ser Cys Ile Asp Gly Gln Cys Val Asn Thr Glu Gly 
        1475                1480                1485


Ser Tyr Asn Cys Phe Cys Thr His Pro Met Val Leu Asp Ala Ser Glu 
    1490                1495                1500


Lys Arg Cys Ile Arg Pro Ala Glu Ser Asn Glu Gln Ile Glu Glu Thr 
1505                1510                1515                1520


Asp Val Tyr Gln Asp Leu Cys Trp Glu His Leu Ser Asp Glu Tyr Val 
                1525                1530                1535


Cys Ser Arg Pro Leu Val Gly Lys Gln Thr Thr Tyr Thr Glu Cys Cys 
            1540                1545                1550


Cys Leu Tyr Gly Glu Ala Trp Gly Met Gln Cys Ala Leu Cys Pro Leu 
        1555                1560                1565


Lys Asp Ser Asp Asp Tyr Ala Gln Leu Cys Asn Ile Pro Val Thr Gly 
    1570                1575                1580


Arg Arg Gln Pro Tyr Gly Arg Asp Ala Leu Val Asp Phe Ser Glu Gln 
1585                1590                1595                1600


Tyr Thr Pro Glu Ala Asp Pro Tyr Phe Ile Gln Asp Arg Phe Leu Asn 
                1605                1610                1615


Ser Phe Glu Glu Leu Gln Ala Glu Glu Cys Gly Ile Leu Asn Gly Cys 
            1620                1625                1630


Glu Asn Gly Arg Cys Val Arg Val Gln Glu Gly Tyr Thr Cys Asp Cys 
        1635                1640                1645


Phe Asp Gly Tyr His Leu Asp Thr Ala Lys Met Thr Cys Val Asp Val 
    1650                1655                1660


Asn Glu Cys Asp Glu Leu Asn Asn Arg Met Ser Leu Cys Lys Asn Ala 
1665                1670                1675                1680


Lys Cys Ile Asn Thr Asp Gly Ser Tyr Lys Cys Leu Cys Leu Pro Gly 
                1685                1690                1695


Tyr Val Pro Ser Asp Lys Pro Asn Tyr Cys Thr Pro Leu Asn Thr Ala 
            1700                1705                1710


Leu Asn Leu Glu Lys Asp Ser Asp Leu Glu 
        1715                1720


<210>  139
<211>  1719
<212>  DNA
<213>  Homo sapiens

<400>  139
ggcgatggga aggcgggcgc agtcgaccca agggtggaga agagggaagg cgaaggacgc     60

gcgttcccgg gctcgtgacc gccagcggcc cggggaaccc gctcccagac agactcggag    120

agatggcagg cggaagacac cggcgcgtcg tgggcaccct ccacctgctg ctgctggtgg    180

ccgccctgcc ctgggcatcc aggggggtca gtccgagtgc ctcagcctgg ccagaggaga    240

agaattacca ccagccagcc attttgaatt catcggctct tcggcaaatt gcagaaggca    300

ccagtatctc tgaaatgtgg caaaatgact tacagccatt gctgatagag cgatacccgg    360

gatcccctgg aagctatgct gctcgtcagc acatcatgca gcgaattcag aggcttcagg    420

ctgactgggt cttggaaata gacaccttct tgagtcagac accctatggg taccggtctt    480

tctcaaatat catcagcacc ctcaatccca ctgctaaacg acatttggtc ctcgcctgcc    540

actatgactc caagtatttt tcccactgga acaacagagt gtttgtagga gccactgatt    600

cagccgtgcc atgtgcaatg atgttggaac ttgctcgtgc cttagacaag aaactccttt    660

ccttaaagac tgtttcagac tccaagccag atttgtcact ccagctgatc ttctttgatg    720

gtgaagaggc ttttcttcac tggtctcctc aagattctct ctatgggtct cgacacttag    780

ctgcaaagat ggcatcgacc ccgcacccac ctggagcgag aggcaccagc caactgcatg    840

gcatggattt attggtctta ttggatttga ttggagctcc aaacccaacg tttcccaatt    900

tttttccaaa ctcagccagg tggttcgaaa gacttcaagc aattgaacat gaacttcatg    960

aattgggttt gctcaaggat cactctttgg aggggcggta tttccagaat tacagttatg   1020

gaggtgtgat tcaggatgac catattccat ttttaagaag aggtgttcca gttctgcatc   1080

tgataccgtc tcctttccct gaagtctggc acaccatgga tgacaatgaa gaaaatttgg   1140

atgaatcaac cattgacaat ctaaacaaaa tcctacaagt ctttgtgttg gaatatcttc   1200

atttgtaata ctctgattta gtttaggata attggttcta gaattgaatt caaaagtcaa   1260

ggcatcattt aaaataatct gatttcagac aaatgctgtg tggaaacatc tatcctatag   1320

atcatcctat tcttatgtgt ctttggttat cagatcaatt acagaataat tgtgttgtga   1380

tattgtgtcc taaattgctc attaattttt atttacagat tgaaaaagag ggaccgtgta   1440

aagaaaatgg aaaataaata tctttcaaag actcttttag ataaacacga tgaggcaaaa   1500

tcaggttcat tcattcaacg atagtttctc aacagtactt aaatagcggt tggaaaacgt   1560

agccttcatt ttatgatttt ttcatatgtg gaaatctatt acatgtaata caaaacaaac   1620

atgtagtttg aaggcggtca gatttctttg agaaatcttt gtagagttaa ttttatggaa   1680

attaaaatca gaattaaatg ctaaaaaaaa aaaaaaaaa                          1719


<210>  140
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  140

Met Ala Gly Gly Arg His Arg Arg Val Val Gly Thr Leu His Leu Leu 
1               5                   10                  15


Leu Leu Val Ala Ala Leu Pro Trp Ala Ser Arg Gly Val Ser Pro Ser 
            20                  25                  30


Ala Ser Ala Trp Pro Glu Glu Lys Asn Tyr His Gln Pro Ala Ile Leu 
        35                  40                  45


Asn Ser Ser Ala Leu Arg Gln Ile Ala Glu Gly Thr Ser Ile Ser Glu 
    50                  55                  60


Met Trp Gln Asn Asp Leu Gln Pro Leu Leu Ile Glu Arg Tyr Pro Gly 
65                  70                  75                  80


Ser Pro Gly Ser Tyr Ala Ala Arg Gln His Ile Met Gln Arg Ile Gln 
                85                  90                  95


Arg Leu Gln Ala Asp Trp Val Leu Glu Ile Asp Thr Phe Leu Ser Gln 
            100                 105                 110


Thr Pro Tyr Gly Tyr Arg Ser Phe Ser Asn Ile Ile Ser Thr Leu Asn 
        115                 120                 125


Pro Thr Ala Lys Arg His Leu Val Leu Ala Cys His Tyr Asp Ser Lys 
    130                 135                 140


Tyr Phe Ser His Trp Asn Asn Arg Val Phe Val Gly Ala Thr Asp Ser 
145                 150                 155                 160


Ala Val Pro Cys Ala Met Met Leu Glu Leu Ala Arg Ala Leu Asp Lys 
                165                 170                 175


Lys Leu Leu Ser Leu Lys Thr Val Ser Asp Ser Lys Pro Asp Leu Ser 
            180                 185                 190


Leu Gln Leu Ile Phe Phe Asp Gly Glu Glu Ala Phe Leu His Trp Ser 
        195                 200                 205


Pro Gln Asp Ser Leu Tyr Gly Ser Arg His Leu Ala Ala Lys Met Ala 
    210                 215                 220


Ser Thr Pro His Pro Pro Gly Ala Arg Gly Thr Ser Gln Leu His Gly 
225                 230                 235                 240


Met Asp Leu Leu Val Leu Leu Asp Leu Ile Gly Ala Pro Asn Pro Thr 
                245                 250                 255


Phe Pro Asn Phe Phe Pro Asn Ser Ala Arg Trp Phe Glu Arg Leu Gln 
            260                 265                 270


Ala Ile Glu His Glu Leu His Glu Leu Gly Leu Leu Lys Asp His Ser 
        275                 280                 285


Leu Glu Gly Arg Tyr Phe Gln Asn Tyr Ser Tyr Gly Gly Val Ile Gln 
    290                 295                 300


Asp Asp His Ile Pro Phe Leu Arg Arg Gly Val Pro Val Leu His Leu 
305                 310                 315                 320


Ile Pro Ser Pro Phe Pro Glu Val Trp His Thr Met Asp Asp Asn Glu 
                325                 330                 335


Glu Asn Leu Asp Glu Ser Thr Ile Asp Asn Leu Asn Lys Ile Leu Gln 
            340                 345                 350


Val Phe Val Leu Glu Tyr Leu His Leu 
        355                 360


<210>  141
<211>  1697
<212>  DNA
<213>  Homo sapiens

<400>  141
gcgggtgtgt gtgtgtgtgg atgtgtgtgg ggtgtgggtg tcccttacgc ccttcctcct     60

ctccctcctc ctcctgctcc cccctccttt ccttctcctc ctcccccctc tcctctccct    120

cctcctggtc ctcatcgccc ctctcctcct cttcctcccc tctctcttcc tctccctgaa    180

ttttctcctc tcctctcagg tcagtccatg gtattccgct cccccctaga cctctattcc    240

tcccacttct tgttgccaaa cttcgccgat tctcaccacc gctccatact tctggcgagt    300

agcggcggcg ggaacggtgc gggaggcggc ggcggcgcgg gaggcggcag cggcggcggg    360

aacggtgcgg gaggcggcgg tgctggcgga gcaggcggcg gcggcggcgg cggctccagg    420

gcccccccgg aagagttgtc catgttccag ctgcccaccc tcaacttctc gccggagcag    480

gtggccagcg tctgtgagac gctggaggag acgggcgaca tcgagcggct gggccgcttc    540

ctctggtcgc tgcccgtggc ccccggggcg tgcgaggcca tcaacaaaca cgagtcgatc    600

ctgcgcgcgc gcgccgtggt cgccttccac acgggcaact tccgcgacct ctaccacatc    660

cttgagaacc acaagttcac caaggagtct cacggcaagc tgcaggccat gtggctcgag    720

gcgcactacc aggaggccga gaagctgcgc ggccgcccac tcggcccggt ggacaagtac    780

cgcgtgcgca agaagttccc gctgccacgc accatctggg acggcgagca gaagacgcat    840

tgcttcaagg agcggactcg gagcctgttg cgggagtggt acctacagga cccctacccc    900

aaccccagca agaaacgcga actggcgcag gccaccggcc tcactcccac acaagtaggc    960

aactggttta agaaccggcg gcagcgcgac cgcgccgcgg cggccaagaa caggctccag   1020

caccaggcca ttggaccgag cggcatgcgc tcgctggccg agcccggctg ccccacgcac   1080

ggctcggcag agtcgccgtc cacggcggcc agcccgacca ccagcgtgtc cagcctgacg   1140

gagcgcgcag acaccggcac ctccatcctc tcggtaacct ccagcgactc ggaatgtgat   1200

gtatgatagc caaggccgcc ctcctccctc tccttcccct cctcccccac tccttcccct   1260

ccgcctccta gccctcctcc tcttcctcct cttccttctc ctcctccatc cccagaacaa   1320

accgaaatca ggatacccaa ccatacacac atacaagtcc acacacactc ccaccccagc   1380

caaaaatata taaaaaacaa gaaaataaca aattaaccgc aaactatcaa caacccccaa   1440

ccaccatcta ccactacggc caccccaaag gaccccgacg ccaacagaca gtcaaacgct   1500

gatgttgcgg gcagaaaaca taaaagaggt gacaattgta tactttctag gacaagcacg   1560

gcttctcctt tcggttccca tggacccggc accccacctg catgacgatt tatttgtatc   1620

tgggaaaata ttctctctag ttaaaaatga tttaaagagt cgactataca aaaatcaatc   1680

accaccacga ggacaag                                                  1697


<210>  142
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  142

Met Val Phe Arg Ser Pro Leu Asp Leu Tyr Ser Ser His Phe Leu Leu 
1               5                   10                  15


Pro Asn Phe Ala Asp Ser His His Arg Ser Ile Leu Leu Ala Ser Ser 
            20                  25                  30


Gly Gly Gly Asn Gly Ala Gly Gly Gly Gly Gly Ala Gly Gly Gly Ser 
        35                  40                  45


Gly Gly Gly Asn Gly Ala Gly Gly Gly Gly Ala Gly Gly Ala Gly Gly 
    50                  55                  60


Gly Gly Gly Gly Gly Ser Arg Ala Pro Pro Glu Glu Leu Ser Met Phe 
65                  70                  75                  80


Gln Leu Pro Thr Leu Asn Phe Ser Pro Glu Gln Val Ala Ser Val Cys 
                85                  90                  95


Glu Thr Leu Glu Glu Thr Gly Asp Ile Glu Arg Leu Gly Arg Phe Leu 
            100                 105                 110


Trp Ser Leu Pro Val Ala Pro Gly Ala Cys Glu Ala Ile Asn Lys His 
        115                 120                 125


Glu Ser Ile Leu Arg Ala Arg Ala Val Val Ala Phe His Thr Gly Asn 
    130                 135                 140


Phe Arg Asp Leu Tyr His Ile Leu Glu Asn His Lys Phe Thr Lys Glu 
145                 150                 155                 160


Ser His Gly Lys Leu Gln Ala Met Trp Leu Glu Ala His Tyr Gln Glu 
                165                 170                 175


Ala Glu Lys Leu Arg Gly Arg Pro Leu Gly Pro Val Asp Lys Tyr Arg 
            180                 185                 190


Val Arg Lys Lys Phe Pro Leu Pro Arg Thr Ile Trp Asp Gly Glu Gln 
        195                 200                 205


Lys Thr His Cys Phe Lys Glu Arg Thr Arg Ser Leu Leu Arg Glu Trp 
    210                 215                 220


Tyr Leu Gln Asp Pro Tyr Pro Asn Pro Ser Lys Lys Arg Glu Leu Ala 
225                 230                 235                 240


Gln Ala Thr Gly Leu Thr Pro Thr Gln Val Gly Asn Trp Phe Lys Asn 
                245                 250                 255


Arg Arg Gln Arg Asp Arg Ala Ala Ala Ala Lys Asn Arg Leu Gln His 
            260                 265                 270


Gln Ala Ile Gly Pro Ser Gly Met Arg Ser Leu Ala Glu Pro Gly Cys 
        275                 280                 285


Pro Thr His Gly Ser Ala Glu Ser Pro Ser Thr Ala Ala Ser Pro Thr 
    290                 295                 300


Thr Ser Val Ser Ser Leu Thr Glu Arg Ala Asp Thr Gly Thr Ser Ile 
305                 310                 315                 320


Leu Ser Val Thr Ser Ser Asp Ser Glu Cys Asp Val 
                325                 330


<210>  143
<211>  737
<212>  DNA
<213>  Homo sapiens

<400>  143
atgcagcccc cagccctggc taagccccgc ctctcaggcc ctggaggcag aaagctcctc     60

agcctggccc ctccgggatt ctggatccag ctgtcctggt tgctgcctaa ctttcagccg    120

tgtgtccagc atatctgtga actgatctgg ggccagagct cagggaaaaa cagagacact    180

caggaaaatg aagcaaccat ttcctccctc caccaggata tgttgatcct aagcccagaa    240

agctccagcc aattgaataa gagtaaaagt gccgttttct tggtcagagg cgccaatttg    300

actcacaggc agggcatgat ggtggtgggt acagacacct cactggcgat ctcctccctc    360

ctgtccctgc tgctcttcac tgggatgcag atgtagatcc atcagctggc ctccaccgag    420

tggcttacca tccagggtgg cctgcatggc tcaggtctct tcgtgctctc cctcactgcc    480

ttcaagattc tggagaatct tgtgtttggc aaaggatccc aagcaaagac cttccctgag    540

attctcctgt gcctcctgtt ggctctcttt gcatctggcc tcatccaccg agtctgtgtc    600

accacctgct tcatcttctc cgtggttggt ctgtgctaca tcaacaagat ctccactctg    660

tatcaggcag cagctgcagt cctcacagga ccttggctct tgccaaggtc acaggcaaga    720

gcaagaagag aaattga                                                   737


<210>  144
<211>  2132
<212>  DNA
<213>  Homo sapiens

<400>  144
cgcggagcat gcggagcggc gccccgggcg gcccccgggc ttgggcgagg gcttgggcca     60

ggcgcgcggg ccgttggggt tcggagcttc gtgggacccg cggccggcgc ggggacgtac    120

ggcagtgact cggggctcac cgggggccag tgccgggcca gggggccagc cccgcccgcg    180

tctcggcccg gacggcccgg cgaggaagct cccatgcggg accgcgcggc ccggtgaggg    240

cgcgcgcggg cgggcgggga cgcagccggc accatgtcca tgctgcccac cttcggcttc    300

acgcaggagc aagtggcgtg cgtgtgcgag gtgctgcagc agggcggcaa catcgagcgg    360

ctgggccgct tcctgtggtc gctgcccgcc tgcgagcacc ttcacaagaa tgaaagcgtg    420

ctcaaggcca aggccgtggt ggccttccac cgcggcaact tccgcgagct ctacaagatc    480

ctggagagcc accagttctc gccgcacaac cacgccaagc tgcagcagct gtggctcaag    540

gcacactaca tcgaggcgga gaagctgcgc ggccgacccc tgggcgccgt gggcaaatac    600

cgcgtgcgcc gcaaattccc gctgccgcgc tccatctggg acggcgagga gaccagctac    660

tgcttcaagg aaaagagtcg cagcgtgctg cgcgagtggt acgcgcacaa cccctaccct    720

tcaccccgcg agaagcgtga gctgacggag gccacgggcc tcaccaccac acaggtcagc    780

aactggttca agaaccggcg gcagcgcgac cgggcggccg aggccaagga aagggagaac    840

aacgagaact ccaattctaa cagccacaac ccgctgaatg gcagcggcaa gtcggtgtta    900

ggcagctcgg aggatgagaa gactccatcg gggacgccag accactcatc atccagcccc    960

gcactgctcc tcagcccgcc gccccctggg ctgccgtccc tgcacagcct gggccaccct   1020

ccgggcccca gcgcagtgcc agtgccggtg ccaggcggag gtggagcgga cccactgcaa   1080

caccaccatg gcctgcagga ctccatcctc aaccccatgt cagccaacct cgtggacctg   1140

ggctcctaga acccatttgc cttgatgagc ttgccttttg tgacttgaca ctggggacgt   1200

ggagtggcgg tgtccagggg cgccccgccc ctgcggcccc accaggtact gaaagacccg   1260

caggctgagc gggtagaaca gccgggtagg gcagatagct gtctatgttg gttcttgttt   1320

gggatttatt ttcaacaagt tacttttagg atccttttgg ggctggagac tgagtcttga   1380

accacagaag ggaataaatt atacaccact gtcattctct ctctccctct gtctcttcct   1440

tttaccctct cttgtcttgc cttttccccc tttcctcttc ctttcccttc cttctctttt   1500

cttttttctg ctttctgtct ttctccctct ccttgtattg ctttccttct agatttctag   1560

cttgccaccg ttcattctct ccttctgtct ctccctttct ctctccttct ctgtttctcc   1620

tctcttctct cctgccagtc tcttgtactc tgtgtcctgg tccctccgta tgtacccctg   1680

tctttctcct cctgactggt ggtctatctg cccctacctc tggccctcgc tttaccggag   1740

tagggggtgg gagagggaag aggagagaaa agacagggac tttgaaccta ggccatctcc   1800

tgaggccttt tccctcgccc atgtgggtca gtgggagctg caggtgtcag cttttcgtct   1860

agtaacttaa gtgagagaga aagggcagcg ccacagaagc ccctaaacgc cgcctcgtca   1920

tacgcccctc ctccttctct cttggcgagg ccccgccaca ccgcgctctt cctcccggga   1980

ctgtgactac agcgctcccg gctgagcgcg ccccccgagc cgccgacttg ccgtctcccc   2040

gtaatgccct catgtgaatg ttcttcggga aatatttctg cttttatttt ataataaaat   2100

tagaaatcat aaataaaaaa aaaaaaaaaa aa                                 2132


<210>  145
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  145

Met Ser Met Leu Pro Thr Phe Gly Phe Thr Gln Glu Gln Val Ala Cys 
1               5                   10                  15


Val Cys Glu Val Leu Gln Gln Gly Gly Asn Ile Glu Arg Leu Gly Arg 
            20                  25                  30


Phe Leu Trp Ser Leu Pro Ala Cys Glu His Leu His Lys Asn Glu Ser 
        35                  40                  45


Val Leu Lys Ala Lys Ala Val Val Ala Phe His Arg Gly Asn Phe Arg 
    50                  55                  60


Glu Leu Tyr Lys Ile Leu Glu Ser His Gln Phe Ser Pro His Asn His 
65                  70                  75                  80


Ala Lys Leu Gln Gln Leu Trp Leu Lys Ala His Tyr Ile Glu Ala Glu 
                85                  90                  95


Lys Leu Arg Gly Arg Pro Leu Gly Ala Val Gly Lys Tyr Arg Val Arg 
            100                 105                 110


Arg Lys Phe Pro Leu Pro Arg Ser Ile Trp Asp Gly Glu Glu Thr Ser 
        115                 120                 125


Tyr Cys Phe Lys Glu Lys Ser Arg Ser Val Leu Arg Glu Trp Tyr Ala 
    130                 135                 140


His Asn Pro Tyr Pro Ser Pro Arg Glu Lys Arg Glu Leu Thr Glu Ala 
145                 150                 155                 160


Thr Gly Leu Thr Thr Thr Gln Val Ser Asn Trp Phe Lys Asn Arg Arg 
                165                 170                 175


Gln Arg Asp Arg Ala Ala Glu Ala Lys Glu Arg Glu Asn Asn Glu Asn 
            180                 185                 190


Ser Asn Ser Asn Ser His Asn Pro Leu Asn Gly Ser Gly Lys Ser Val 
        195                 200                 205


Leu Gly Ser Ser Glu Asp Glu Lys Thr Pro Ser Gly Thr Pro Asp His 
    210                 215                 220


Ser Ser Ser Ser Pro Ala Leu Leu Leu Ser Pro Pro Pro Pro Gly Leu 
225                 230                 235                 240


Pro Ser Leu His Ser Leu Gly His Pro Pro Gly Pro Ser Ala Val Pro 
                245                 250                 255


Val Pro Val Pro Gly Gly Gly Gly Ala Asp Pro Leu Gln His His His 
            260                 265                 270


Gly Leu Gln Asp Ser Ile Leu Asn Pro Met Ser Ala Asn Leu Val Asp 
        275                 280                 285


Leu Gly Ser 
    290


<210>  146
<211>  1449
<212>  DNA
<213>  Homo sapiens

<400>  146
atgtcctccc gcagcccccg gcccccgccc cgccgtagcc gccgccgcct gccgcgcccc     60

tcctgctgct gctgctgctg ccgccgttcg cacctcaacg aggacaccgg ccgcttcgtg    120

ctgctggcgg cgctcatcgg cctctacctg gtggcgggtg ccacagtctt ctcggcgctc    180

gagagccccg gcgaggcgga ggcgcgggcg cgctggggcg ccacgctgcg caacttcagc    240

gctgcgcacg gcgtggccga gccagagctg cgcgccttcc tccggcacta cgaggccgcg    300

ctggccgccg gcgtccgcgc cgacgcgctg cgcccgcgct gggacttccc cggcgccttc    360

tacttcgtgg gcaccgtggt gtcaaccata ggtttcggca tgaccacccc cgcgacggtg    420

ggcgggaagg ccttcctcat cgcctacggg ctgttcggct gcgctgggac catcctgttc    480

ttcaacctct tcctggagcg catcatctcg ctgctggcct tcatcatgcg cgcctgccgg    540

gagcgccagc tgcgccgcag cggcctgctg cccgccacct tccgccgcgg ctccgcgctc    600

tcggaggccg acagcctggc gggctggaag ccctcggtgt accacgtgct gctcatcctg    660

ggcctgttcg ccgtgctgct gtcctgctgc gcctcggcca tgtacaccag cgtggagggc    720

tgggactacg tggactcgct ctacttctgc ttcgtcacct tcagcaccat cggcttcggg    780

gacctggtga gcagccagca cgccgcctac cggaaccagg ggctctaccg cctgggcaac    840

ttcctcttca tcctgctcgg cgtgtgctgc atttactcgc tcttcaacgt catctccatc    900

ctcatcaagc aggtgctcaa ctggatgctg cgcaagctga gctgccgctg ctgcgcgcgc    960

tgctgcccgg ctcctggcgc gcccctggcc cggcgcaatg ccatcacccc aggctcccgg   1020

ctgcgccgcc gcctggccgc gctcggtgcc gaccccgcgg cccgcgacag cgacgccgag   1080

ggccgccgcc tctcgggcga gctcatctcc atgcgcgacc tcacggcctc caacaaggtg   1140

tcgctggcgc tgctgcagaa gcagctgtcg gagacggcca acggctaccc gcgcagcgtg   1200

tgcgtcaaca cgcgccagaa cggcttctcg ggcggcgtgg gcgcgctggg catcatgaac   1260

aaccggctgg ccgagaccag cgcctccagg tagaccgccc gtccgcccgc gccggggacc   1320

ctctccaggc cgcggggccg ccgggcgtgg tttgcttctc tcagtcactg ctggcgcttt   1380

cttaatcttt atccaataaa atgaaacaaa aaaaattttt ttaaaaaaaa aaaaaaaaaa   1440

aaaaaaaaa                                                           1449


<210>  147
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  147

Met Ser Ser Arg Ser Pro Arg Pro Pro Pro Arg Arg Ser Arg Arg Arg 
1               5                   10                  15


Leu Pro Arg Pro Ser Cys Cys Cys Cys Cys Cys Arg Arg Ser His Leu 
            20                  25                  30


Asn Glu Asp Thr Gly Arg Phe Val Leu Leu Ala Ala Leu Ile Gly Leu 
        35                  40                  45


Tyr Leu Val Ala Gly Ala Thr Val Phe Ser Ala Leu Glu Ser Pro Gly 
    50                  55                  60


Glu Ala Glu Ala Arg Ala Arg Trp Gly Ala Thr Leu Arg Asn Phe Ser 
65                  70                  75                  80


Ala Ala His Gly Val Ala Glu Pro Glu Leu Arg Ala Phe Leu Arg His 
                85                  90                  95


Tyr Glu Ala Ala Leu Ala Ala Gly Val Arg Ala Asp Ala Leu Arg Pro 
            100                 105                 110


Arg Trp Asp Phe Pro Gly Ala Phe Tyr Phe Val Gly Thr Val Val Ser 
        115                 120                 125


Thr Ile Gly Phe Gly Met Thr Thr Pro Ala Thr Val Gly Gly Lys Ala 
    130                 135                 140


Phe Leu Ile Ala Tyr Gly Leu Phe Gly Cys Ala Gly Thr Ile Leu Phe 
145                 150                 155                 160


Phe Asn Leu Phe Leu Glu Arg Ile Ile Ser Leu Leu Ala Phe Ile Met 
                165                 170                 175


Arg Ala Cys Arg Glu Arg Gln Leu Arg Arg Ser Gly Leu Leu Pro Ala 
            180                 185                 190


Thr Phe Arg Arg Gly Ser Ala Leu Ser Glu Ala Asp Ser Leu Ala Gly 
        195                 200                 205


Trp Lys Pro Ser Val Tyr His Val Leu Leu Ile Leu Gly Leu Phe Ala 
    210                 215                 220


Val Leu Leu Ser Cys Cys Ala Ser Ala Met Tyr Thr Ser Val Glu Gly 
225                 230                 235                 240


Trp Asp Tyr Val Asp Ser Leu Tyr Phe Cys Phe Val Thr Phe Ser Thr 
                245                 250                 255


Ile Gly Phe Gly Asp Leu Val Ser Ser Gln His Ala Ala Tyr Arg Asn 
            260                 265                 270


Gln Gly Leu Tyr Arg Leu Gly Asn Phe Leu Phe Ile Leu Leu Gly Val 
        275                 280                 285


Cys Cys Ile Tyr Ser Leu Phe Asn Val Ile Ser Ile Leu Ile Lys Gln 
    290                 295                 300


Val Leu Asn Trp Met Leu Arg Lys Leu Ser Cys Arg Cys Cys Ala Arg 
305                 310                 315                 320


Cys Cys Pro Ala Pro Gly Ala Pro Leu Ala Arg Arg Asn Ala Ile Thr 
                325                 330                 335


Pro Gly Ser Arg Leu Arg Arg Arg Leu Ala Ala Leu Gly Ala Asp Pro 
            340                 345                 350


Ala Ala Arg Asp Ser Asp Ala Glu Gly Arg Arg Leu Ser Gly Glu Leu 
        355                 360                 365


Ile Ser Met Arg Asp Leu Thr Ala Ser Asn Lys Val Ser Leu Ala Leu 
    370                 375                 380


Leu Gln Lys Gln Leu Ser Glu Thr Ala Asn Gly Tyr Pro Arg Ser Val 
385                 390                 395                 400


Cys Val Asn Thr Arg Gln Asn Gly Phe Ser Gly Gly Val Gly Ala Leu 
                405                 410                 415


Gly Ile Met Asn Asn Arg Leu Ala Glu Thr Ser Ala Ser Arg 
            420                 425                 430


<210>  148
<211>  977
<212>  DNA
<213>  Homo sapiens

<400>  148
cattcaacag atgcagaaac tgcaggttaa agggtgaaaa gcagttgcga agtccccaca     60

gcttggaaat ggtggagccg agactgaaac ccaggtgtgc tagcatctaa agttcatgct    120

ctttccacca cattagactg tattctgagg gcaccaagga agctccattt ttcttaagaa    180

accaaattgc agtcctccag gaccacagcc aggggagcat cttcgtggga gagtggctgc    240

tgctcagagt tgtgactccc atccttaaga gtcctctgtc ctctctggcc tcctttctac    300

tgatcattgc tgtccccttc acaggggaga ggggccatgg cctatcccct aaagagtctg    360

ccaaggtaga ctcataacct ccccgtggca cagctcagac aagctgggct atttacataa    420

gacttgaccc agggcttgag gacagcgcga ggaatgaggt gcagaggaga ctgctgcttc    480

tgggtgacag tctgcctggc tgaccacagc tggggtactc attggcctct tgaggccccc    540

cacaggcctg ccctgcctga cctactcttg tgaggccaag gccatctcct ccactctctg    600

ggggcctctt ctgactcctc caaactcttc catgtctgga ctcctggctt ctgcccaagg    660

ccatctattg gagtttgggt ttccagttga ggatctgcct ttttcctgga tgaccaaacc    720

tagaatgtga ccggcctcat gctccctcct cacaagggtg tggctttatc cgagggcctc    780

agcaaggcaa ccaacaccag acatgaagct gagcacactc agctcatcct gggagacaag    840

gtgggggtgg aggatggtcc atccttcttc cgcatcaaga tgggaagtct tgactcatta    900

cccgctggag acttttcctg ctgggctctg cactgtcaac tgtgagagag ggaaataaaa    960

cgtactgtac agtccaa                                                   977


<210>  149
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  149

Met Leu Pro Pro His Lys Gly Val Ala Leu Ser Glu Gly Leu Ser Lys 
1               5                   10                  15


Ala Thr Asn Thr Arg His Glu Ala Glu His Thr Gln Leu Ile Leu Gly 
            20                  25                  30


Asp Lys Val Gly Val Glu Asp Gly Pro Ser Phe Phe Arg Ile Lys Met 
        35                  40                  45


Gly Ser Leu Asp Ser Leu Pro Ala Gly Asp Phe Ser Cys Trp Ala Leu 
    50                  55                  60


His Cys Gln Leu 
65


<210>  150
<211>  467
<212>  DNA
<213>  Homo sapiens

<400>  150
tgactggcta ttcaaccaaa ccatacaaat gaccaattcg gtaagaaagc atgaacttca     60

gtgttgaacc aaatcaacca acctcctcaa tccaaatgga gatgcctgtg aaagaggatg    120

ggccagggtc agctttcacc ttcatatcct cccatgcaaa aaacggaagc atgtttgggc    180

tgagaggaca ggttgccagt tgtctgaacc agtcattcca accaggcttc acacttctgc    240

aaagaagaga gggctagaat gcccagtagg agtgcagact ggaggatcgg ctgttttttg    300

aactggagac atcacaggaa actggggagg ctccaaattg ctaacctgag gccggagcaa    360

aaactttttt tttgtcgaag ggactgcttt ttttatttcc ccttcaacgg atggcatccc    420

aagtcctgct ggattgcatc tgtctttgtt cctgcagcca agcctta                  467


<210>  151
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  151

Met Asn Phe Ser Val Glu Pro Asn Gln Pro Thr Ser Ser Ile Gln Met 
1               5                   10                  15


Glu Met Pro Val Lys Glu Asp Gly Pro Gly Ser Ala Phe Thr Phe Ile 
            20                  25                  30


Ser Ser His Ala Lys Asn Gly Ser Met Phe Gly Leu Arg Gly Gln Val 
        35                  40                  45


Ala Ser Cys Leu Asn Gln Ser Phe Gln Pro Gly Phe Thr Leu Leu Gln 
    50                  55                  60


Arg Arg Glu Gly 
65


<210>  152
<211>  437
<212>  DNA
<213>  Homo sapiens

<400>  152
atgaagtaca atccctttgt gacttctgac cgaagcaaga actgcaaaag gcatttcaat     60

gcaccttccc acactcgcag aaagattatg tcttcccctc tttccaaaga gctgagacaa    120

aagtacaatg ttcgatcgaa gaccatccaa aaggatgacg aagttcaggt tgcgcgagga    180

cactgtaagg gtcagcaaat tggccaaata atccaggttt acaggaagaa atatgccatc    240

tacattgaac gggtgcagtg ggaaaaggct aacagcatag ctgtccctgt gggcattcac    300

ccagcaaggt ggttatcact agactaaaac ttgacaaagg ccacaaaaag atccttgaac    360

ggaaagccaa atctcgccaa gtaggaaagg aaaatggcaa atacaagaaa gaaacaatag    420

ggaaggtgca ggaataa                                                   437


<210>  153
<211>  4252
<212>  DNA
<213>  Homo sapiens

<400>  153
aggctgggaa gcggcgccat attggcgtcg gccgcgctgt attgtcataa atagagccgg     60

ttttgtggtg ttttcactac tcggttggat gcctcagcca tagtaagtgg gaaagtgagc    120

gagcaagcga gctactagcg accggaggaa agtgaacagg gggagaaggg aacagcaaga    180

acaggactcc agagcgataa acactcgctg gagagggaga cgcaggaagc gatgaaagag    240

atgtctgcaa acaccgtgct ggacagccag cgtcaacaaa agcattatgg aattacctcc    300

ccaattagtt tggcatctcc taaagaaatt gatcatattt acacacagaa attaattgac    360

gccatgaaac catttggagt gtttgaagat gaggaagaat tgaaccacag gctggtggtt    420

cttggtaaat tgaacaattt agtaaaagaa tggatttctg atgtcagcga gagtaagaac    480

ctcccacctt ctgttgtggc tactgttggt ggtaaaattt tcacatttgg atcctatagg    540

cttggagtac acaccaaagg agctgacatt gatgcacttt gtgtagctcc aagacatgtg    600

gaaagatctg atttttttca gtcttttttt gaaaaattga aacatcaaga tggcattaga    660

aacttaagag ctgtagaaga tgcctttgta cctgttataa aatttgaatt tgatggtatt    720

gaaattgatc tagtctttgc aagactggca atacaaacca tatcagataa tttagatcta    780

agagacgact ctcgcctgag aagccttgat ataaggtgta ttcgcagctt aaatggttgt    840

agagttactg atgaaatttt gcatttagtg ccaaataaag aaacttttag actcacccta    900

agagctgtca aattatgggc aaaacgacgt ggtatttatt ccaacatgct aggattcctt    960

ggtggtgtct cctgggcaat gctagttgca agaacttgcc aattgtatcc aaatgcagca   1020

gcatctactt tagttcataa gttcttttta gttttttcca agtgggaatg gccaaatcct   1080

gtgctgctga agcaaccaga agaaagcaat ttgaatttgc ctgtctggga tcctcgggta   1140

aatccatcag ataggtatca tctcatgccc ataatcaccc ctgcctaccc acaacagaat   1200

tctacgtata atgtgtccac atcaactcga acagtaatgg tagaagaatt taaacaaggt   1260

cttgcagtca cagatgaaat tcttcaagga aagtcagatt ggtccaaact acttgagcca   1320

ccgaatttct ttcaaaagta tagacattat atagtattga ctgccagcgc atcaacagaa   1380

gaaaaccatc tagagtgggt tggattagta gaatctaaaa tccgtgtact tgttggaaac   1440

ttggaacgga atgaatttat tactcttgcc catgtgaatc cccagtcatt cccagggaat   1500

aaggaacatc ataaagacaa caattacgta tcaatgtggt tccttgggat aatttttcgg   1560

agagtagaaa atgcagaaag tgtcaacata gacttgacat atgatataca gtcatttact   1620

gatacagtgt acagacaggc aaacaatata aatatgctaa aggagggaat gaaaattgaa   1680

gcaactcatg taaagaaaaa acaacttcac cactaccttc ctgcagaaat tcttcaaaag   1740

aagaaaaagc aaagtctctc tgatgtcaat cgaagctcgg gcggacttca atccaaaaga   1800

ttgtctctgg atagcagttg tctggatagc tccagagaca ctgataatgg aacacctttt   1860

aattctccag cgtccaagtc tgatagccct tctgtaggag aaacagaaag gaatagtgct   1920

gagcctgctg ctgtaattgt ggagaagcca ctgagtgtac caccagccca aggactttcc   1980

attccagtga ttggcgcaaa agttgactct acagtaaaaa ctgtatcacc ccccactgtg   2040

tgtaccattc ctaccgtagt aggacgaaat gtcattccta gaatcacaac acctcacaac   2100

cctgcccagg gacaaccgca tctgaatgga atgtcaaata taactaagac tgttacacct   2160

aagagatccc attccccatc catagatggg actcctaaga ggttgaaaga cgtagaaaag   2220

tttattcgac ttgaatcaac atttaaggac ccccgcactg ctgaagaaag aaaaagaaaa   2280

tcagtggatg ccattggagg agaatctatg cctattccaa ctattgatac atcacgcaaa   2340

aagagactac ccagtaaaga actaccagat tcatcatctc cagttccagc aaacaacatc   2400

cgtgtcatca aaaattccat tcgactgacc cttaatcggt aaaagcagtg cctcctcact   2460

taagtgaaca agcaatcatt tagtggcata gatgcagcca cttgtttttt aaatagaagt   2520

ggctgtcata cgtgaaataa ggtgaaagtg acagccttca gtctaataac cttgaagtgg   2580

tttttgaact gtcaaacttt gacctgtaga tgctgtagca ttctctcact gattgctaca   2640

tacacttctc tgaggatcac ctgctgtcaa attgccatct acagtattac agctttgcat   2700

ttgggggttt tactgcctta actttcaatg cttgttatgg gaaccagttc ttagccactt   2760

ggacactgat aacaagtcct gaactccttt tttgttttgt tttttgtgtt tttctttttt   2820

tgtcttatgt tgtaatcatt gtatagagct aaaaaaattg aaaacaaaca aaaaaattgt   2880

cttgtatttt ccaaatgtta atacatttac tttagcattg aagccacttt gaaacctgag   2940

ataaatgaat gtgaggtatc ttttctgctt tcctcatttg tgtagatgta ctgtctgttc   3000

tgttgattta aattattttt ttccagattg gcacatgaaa tatttaaact tttttgtgtg   3060

cctttctgtc caaatgttgc atagttacca gggaagatta gtccagtgat tacataagag   3120

ttgggcacca taaattctct atattttgcc tcccatggag gcctttgaaa tgcatcttta   3180

ttaaaaatca aaatataacc aggatactga aagtcagtat atgaatggta aaattgttac   3240

atatcctatt tcatgccatt cttgttagtt gactggtatt ttttactgag gagcaactca   3300

ttccagcatc aacaataaga taacctttaa gtatggcaca cttgtatttt tgaggtgtaa   3360

aattaacttg gcatgataat tcctgatcat tatttacccc acaacttcaa atagtttctt   3420

cacggactag gcatgcagaa ataagcagtg gattttattg aaacctaaag gcattttgaa   3480

tgacattgtt accaaccatt aattggctca ggacctttgt aatttttatt taactatatg   3540

agttgtcttt ttttacgctg cttttttcaa tgcatttctt aatatttttt aagtttcatg   3600

aatgcatgct cagtttatta aaatccataa ccatgtaatt cttgtaatat gttgattcag   3660

tgttttgtaa atgaagtcgt atgtattttc agagtatttt tgtatgtact gtaagatacc   3720

atcttttcaa agagaaacgt ttaaaacctt tattgtctct ccttagtcta attttttaaa   3780

tatggattat gcttgaatta ctatatttaa aatgaaaatg tatagattac acagccagga   3840

atgctagtat ctaccacctt ctttagattt cactcagcat ttagtaggtc cagtaggaaa   3900

aacccaaaat ggtacattga gtagtgtggg gaagacacct cgtgtattat aggactcacg   3960

ggatgccatc tagcaagtgg agaaatagca gtccattttc tcttgcaagc cctttaccat   4020

tgagttgaaa ttcttgaatt gccagagagc cgtatcctcc aggtcccact cctgttcatt   4080

gccccttagg tctccaaaat gtaaattcta atgtttacct tgtaccatgg aaaacatgaa   4140

aagagtctta gaagtaaaga acaacaagga aaaaaatgtt tgttctatta ttcccttttt   4200

atatagcagc aaaagataag aataaaatca cataaccaag ttgaaaaaaa aa           4252


<210>  154
<211>  736
<212>  PRT
<213>  Homo sapiens

<400>  154

Met Lys Glu Met Ser Ala Asn Thr Val Leu Asp Ser Gln Arg Gln Gln 
1               5                   10                  15


Lys His Tyr Gly Ile Thr Ser Pro Ile Ser Leu Ala Ser Pro Lys Glu 
            20                  25                  30


Ile Asp His Ile Tyr Thr Gln Lys Leu Ile Asp Ala Met Lys Pro Phe 
        35                  40                  45


Gly Val Phe Glu Asp Glu Glu Glu Leu Asn His Arg Leu Val Val Leu 
    50                  55                  60


Gly Lys Leu Asn Asn Leu Val Lys Glu Trp Ile Ser Asp Val Ser Glu 
65                  70                  75                  80


Ser Lys Asn Leu Pro Pro Ser Val Val Ala Thr Val Gly Gly Lys Ile 
                85                  90                  95


Phe Thr Phe Gly Ser Tyr Arg Leu Gly Val His Thr Lys Gly Ala Asp 
            100                 105                 110


Ile Asp Ala Leu Cys Val Ala Pro Arg His Val Glu Arg Ser Asp Phe 
        115                 120                 125


Phe Gln Ser Phe Phe Glu Lys Leu Lys His Gln Asp Gly Ile Arg Asn 
    130                 135                 140


Leu Arg Ala Val Glu Asp Ala Phe Val Pro Val Ile Lys Phe Glu Phe 
145                 150                 155                 160


Asp Gly Ile Glu Ile Asp Leu Val Phe Ala Arg Leu Ala Ile Gln Thr 
                165                 170                 175


Ile Ser Asp Asn Leu Asp Leu Arg Asp Asp Ser Arg Leu Arg Ser Leu 
            180                 185                 190


Asp Ile Arg Cys Ile Arg Ser Leu Asn Gly Cys Arg Val Thr Asp Glu 
        195                 200                 205


Ile Leu His Leu Val Pro Asn Lys Glu Thr Phe Arg Leu Thr Leu Arg 
    210                 215                 220


Ala Val Lys Leu Trp Ala Lys Arg Arg Gly Ile Tyr Ser Asn Met Leu 
225                 230                 235                 240


Gly Phe Leu Gly Gly Val Ser Trp Ala Met Leu Val Ala Arg Thr Cys 
                245                 250                 255


Gln Leu Tyr Pro Asn Ala Ala Ala Ser Thr Leu Val His Lys Phe Phe 
            260                 265                 270


Leu Val Phe Ser Lys Trp Glu Trp Pro Asn Pro Val Leu Leu Lys Gln 
        275                 280                 285


Pro Glu Glu Ser Asn Leu Asn Leu Pro Val Trp Asp Pro Arg Val Asn 
    290                 295                 300


Pro Ser Asp Arg Tyr His Leu Met Pro Ile Ile Thr Pro Ala Tyr Pro 
305                 310                 315                 320


Gln Gln Asn Ser Thr Tyr Asn Val Ser Thr Ser Thr Arg Thr Val Met 
                325                 330                 335


Val Glu Glu Phe Lys Gln Gly Leu Ala Val Thr Asp Glu Ile Leu Gln 
            340                 345                 350


Gly Lys Ser Asp Trp Ser Lys Leu Leu Glu Pro Pro Asn Phe Phe Gln 
        355                 360                 365


Lys Tyr Arg His Tyr Ile Val Leu Thr Ala Ser Ala Ser Thr Glu Glu 
    370                 375                 380


Asn His Leu Glu Trp Val Gly Leu Val Glu Ser Lys Ile Arg Val Leu 
385                 390                 395                 400


Val Gly Asn Leu Glu Arg Asn Glu Phe Ile Thr Leu Ala His Val Asn 
                405                 410                 415


Pro Gln Ser Phe Pro Gly Asn Lys Glu His His Lys Asp Asn Asn Tyr 
            420                 425                 430


Val Ser Met Trp Phe Leu Gly Ile Ile Phe Arg Arg Val Glu Asn Ala 
        435                 440                 445


Glu Ser Val Asn Ile Asp Leu Thr Tyr Asp Ile Gln Ser Phe Thr Asp 
    450                 455                 460


Thr Val Tyr Arg Gln Ala Asn Asn Ile Asn Met Leu Lys Glu Gly Met 
465                 470                 475                 480


Lys Ile Glu Ala Thr His Val Lys Lys Lys Gln Leu His His Tyr Leu 
                485                 490                 495


Pro Ala Glu Ile Leu Gln Lys Lys Lys Lys Gln Ser Leu Ser Asp Val 
            500                 505                 510


Asn Arg Ser Ser Gly Gly Leu Gln Ser Lys Arg Leu Ser Leu Asp Ser 
        515                 520                 525


Ser Cys Leu Asp Ser Ser Arg Asp Thr Asp Asn Gly Thr Pro Phe Asn 
    530                 535                 540


Ser Pro Ala Ser Lys Ser Asp Ser Pro Ser Val Gly Glu Thr Glu Arg 
545                 550                 555                 560


Asn Ser Ala Glu Pro Ala Ala Val Ile Val Glu Lys Pro Leu Ser Val 
                565                 570                 575


Pro Pro Ala Gln Gly Leu Ser Ile Pro Val Ile Gly Ala Lys Val Asp 
            580                 585                 590


Ser Thr Val Lys Thr Val Ser Pro Pro Thr Val Cys Thr Ile Pro Thr 
        595                 600                 605


Val Val Gly Arg Asn Val Ile Pro Arg Ile Thr Thr Pro His Asn Pro 
    610                 615                 620


Ala Gln Gly Gln Pro His Leu Asn Gly Met Ser Asn Ile Thr Lys Thr 
625                 630                 635                 640


Val Thr Pro Lys Arg Ser His Ser Pro Ser Ile Asp Gly Thr Pro Lys 
                645                 650                 655


Arg Leu Lys Asp Val Glu Lys Phe Ile Arg Leu Glu Ser Thr Phe Lys 
            660                 665                 670


Asp Pro Arg Thr Ala Glu Glu Arg Lys Arg Lys Ser Val Asp Ala Ile 
        675                 680                 685


Gly Gly Glu Ser Met Pro Ile Pro Thr Ile Asp Thr Ser Arg Lys Lys 
    690                 695                 700


Arg Leu Pro Ser Lys Glu Leu Pro Asp Ser Ser Ser Pro Val Pro Ala 
705                 710                 715                 720


Asn Asn Ile Arg Val Ile Lys Asn Ser Ile Arg Leu Thr Leu Asn Arg 
                725                 730                 735


<210>  155
<211>  5077
<212>  DNA
<213>  Homo sapiens

<400>  155
ctatgctgcg agaagacgac agaaggggga gcggctatga gaagggaacg gggccagact     60

cagcccgaca gcgggattag agccctccag aatacccatc atatagcccc tgaggtggca    120

tggtgatgtc tccatgaggg aaccccttcc cactcatcct gtcacgtata tcatagtgtt    180

cttgactggg ccattcatct aagatgggat ttaccctgtg aaacagggag aagacttatg    240

gaccccaagc atcatttcga gttgtagttg agtttttaaa agacatacat gcaaagttcc    300

tttgctttgg accctctgca ttattaaagc tgctgtattg ctaacccaga actgctccag    360

tgtcttgact gatcatcatg gcttcagttt ggaagagact gcagcgtgtg ggaaaacatg    420

catccaagtt ccagtttgtg gcctcctacc aggagctcat ggttgagtgt acgaagaaat    480

ggcaaccaga taaactggtg gtagtttgga ccagaagaag ccgaaggaag tcttctaagg    540

cacatagctg gcaacctgga ataaaaaatc cctatcgtgg tgttgttgtg tggcctgttc    600

ctgaaaacat tgaaatcact gtaacacttt ttaaggatcc tcatgcggaa gaatttgaag    660

acaaagagtg gacatttgtc atagaaaatg aatccccttc tggtcgaagg agagctcttg    720

ctactagcag catcaatatg aaacagtatg caagccctat gccaactcag actgatgtca    780

agttaaaatt caagccatta tctaaaaaag ttgtatctgc cgctcttcag ttttcattat    840

cttgcatttt tctgagggaa ggaaaagcca cagatgaaga catgcaaagt ttggctagtt    900

tgatgagtat gaagcaggct gacattggca atttagatga cttcgaagaa gataatgaag    960

atgatgatga gaacagagtg aaccaagaag aaaaggcagc taaaattaca ggaattgtaa   1020

accagttgaa tgctctgagc agcttagatg aagatcaaga tgactgcata aagcaagcaa   1080

atatgcgttc agctaaatca gccagttcct ctgaagagct tatcaacaaa cttaactttt   1140

tggttgaagc agaaaaggac ttggccaccg tgaattcaaa tccatttgat gatcctgatg   1200

ctgcagaatt aaatccattt ggagatcctg actcagaaga acctatcact gaaacagctt   1260

cacctagaaa aacagaagac tctttttata ataacagcta taatcccttt aaagaggtgc   1320

agactccaca gtatttgaac ccattcgatg agccagaagc atttgtgacc ataaaggatt   1380

ctcctcccca gtctacaaaa ggaaaaaata taagacctgt ggatatgagc aagtacctct   1440

atgctgatag ttctaaaact gaagaagaag aattggatga atcaaatcct ttttatgaac   1500

ctaaatcaac tcctcctcca aataatttgg taaatcctgt tcaagaacta gaaactgaaa   1560

ggcgagtgaa aagaaaggcc ccggctccac cagtcctctc accaaaaaca ggagtattaa   1620

atgaaaacac agtttctgca ggaaaagatc tctctacttc tcctaagcca agccctatac   1680

caagtcctgt tttggggcga aagccaaatg ctagtcagtc tttgcttgta tggtgtaaag   1740

aagttacaaa gaactaccga ggagtaaaaa tcaccaattt tactacatcg tggagaaatg   1800

gtttatcttt ttgtgcaata ttacaccact ttagaccaga tttaattgac tacaagtctc   1860

tgaatcctca agatattaaa gagaacaaca aaaaggcata cgatggattt gccagcatag   1920

gaatttcccg attattggaa ccttctgata tggtattatt agcaattcct gataaactga   1980

ctgttatgac ttatctctat caaataaggg cacatttcag tggccaagaa ctaaatgtcg   2040

ttcagataga ggaaaacagc agtaaaagca catataaagt tggaaactat gaaacagata   2100

caaacagttc tgttgatcaa gaaaaattct atgcagagct tagtgatctg aagcgggagc   2160

ctgaactaca acagcctatc agcggagcag tagacttctt atcacaggat gactctgtat   2220

ttgtaaatga tagcggggtt ggagagtcag aaagtgagca tcaaactcct gatgatcacc   2280

ttagtccaag cacagcctcc ccttactgtc gcaggactaa aagtgacaca gaaccccaga   2340

agtctcagca gagctctgga aggacttcag gatctgatga ccctggaata tgttccaata   2400

cagattcaac ccaagcacag gttttgttag gcaaaaagag actattgaaa gctgagactt   2460

tagaattgag tgacttatat gttagtgata agaagaagga tatgtctcca ccctttattt   2520

gtgaggagac agatgaacaa aagcttcaaa ctctagacat cggtagtaac ttggagaaag   2580

aaaaattaga gaattccaga tccttagaat gcagatcaga tccagaatct cctatcaaaa   2640

aaacaagttt atctcctact tctaaacttg gatactcata tagtagagat ctagaccttg   2700

ctaagaaaaa acatgcttcc ctgaggcaga cggagtctga tccagatgct gatagaacca   2760

ctttaaatca tgcagatcat tcatcaaaaa tagtccagca tcgattgtta tctagacaag   2820

aagaacttaa ggaaagagca agagttctgc ttgagcaagc aagaagagat gcagccttaa   2880

aggcggggaa taagcacaat accaacacag ccaccccatt ctgcaacagg cagctaagtg   2940

atcagcaaga tgaagagcga cgtcggcagc tgagagagag agctcgtcag ctaatagcag   3000

aagctcgatc tggagtgaag atgtcagaac ttcccagcta tggtgaaatg gctgcagaaa   3060

agttgaaaga aaggtcaaag gcatctggag atgaaaatga taatattgag atagatacta   3120

acgaggagat ccctgaaggc tttgttgtag gaggtggaga tgaacttact aacttagaaa   3180

atgaccttga tactcccgaa caaaacagta agttggtgga cttgaagctg aagaagctcc   3240

tagaagttca gccacaggtg gcaaattcac cctccagtgc tgcccagaaa gctgtaactg   3300

agagctcaga gcaggacatg aaaagtggca cagaagatct ccggactgaa cgattacaaa   3360

aaacaacaga acgttttaga aatcctgttg tgttcagcaa agattctaca gtcagaaaaa   3420

ctcaacttca gtctttcagc caatatattg agaatagacc agagatgaaa aggcagagat   3480

caatacagga agatacaaag aaaggaaatg aggagaaggc agcgataact gaaactcaga   3540

ggaagccatc agaagatgaa gtgcttaata aagggttcaa agacaccagt cagtatgtag   3600

taggagaatt ggcagcacta gagaatgagc aaaagcaaat tgacacccgt gccgcgctgg   3660

tggagaagcg ccttcgctat ctcatggaca caggaaggaa cacagaagaa gaagaagcta   3720

tgatgcagga atggtttatg ttagttaata agaaaaatgc cttaataagg agaatgaatc   3780

agctctctct tctggaaaaa gaacatgatt tagaacgacg gtatgagctg ctgaaccggg   3840

aattgagggc aatgctagcc attgaagact ggcagaagac cgaggcccag aagcgacgcg   3900

aacagcttct gctagatgag ctggtggccc tggtgaacaa gcgcgatgcg ctcgtcaggg   3960

acctggacgc gcaggagaag caggccgaag aagaagatga gcatttggag cgaactctgg   4020

agcaaaacaa aggcaagatg gccaagaaag aggagaaatg tgttcttcag tagccatcag   4080

atcagaaaga atctctccca acattttaga gtcttgcttc ccaaaccaga aaaagtcaga   4140

ctcattgttg atttaaaact tttaacattt tgtttggctg gattgtacta ctttacctct   4200

actttaccac caccaccctt ttcctccctc ctttccaaat aatatacaga actccaaaat   4260

agcttcattt aaggattttt ttgtgagtta acaatttcct tgaaatcctg tgagatagat   4320

ttgcacagac accttgtgag tgattggtat tggaggtgtt caagaaactg ttcgaaaaag   4380

aacaaaaaca cttccctcgt tattttctct cattttttga tgagaggaaa atttgaaaca   4440

ttattcttgt tgttgttggt aatagcataa tgacagtggg aggggtacaa ggggataaga   4500

aaaatgtcat gatttttttc cggtcctgcc acatgtaaca cttactctgt tacctaaatt   4560

ttatagttag atcatatcca atctacttat taaactgtgt tctatttacc agtggagatt   4620

ttctgcagtg gttgcgtttc actgtaagga taatggagtt cctctcctct gctttcctca   4680

gaggatggtc ctttaacata gccagaaaca agccctgtgg tttgaaggtg agctgtgagg   4740

atgggactaa ttgatatgca ccagtttaca aagacagtct taacatccga gaatacacca   4800

tctttttctc tggataatta tttcttacat catgcttgat tcctacattt tgttgggtct   4860

caacattggc tcacgaatgc tgttaatatt tattctgtat tgataaaaag tcagtcttgc   4920

cactacaagt aaatccccca tttaatattt tcttctttag catagcactg tcattttttg   4980

tgaaaatggt tatgtttatt tattacaata ctgagtcata tataaatttt caataaaagc   5040

agaaactttc ttaccttaaa aaaaaaaaaa aaaaaaa                            5077


<210>  156
<211>  1231
<212>  PRT
<213>  Homo sapiens

<400>  156

Met Ala Ser Val Trp Lys Arg Leu Gln Arg Val Gly Lys His Ala Ser 
1               5                   10                  15


Lys Phe Gln Phe Val Ala Ser Tyr Gln Glu Leu Met Val Glu Cys Thr 
            20                  25                  30


Lys Lys Trp Gln Pro Asp Lys Leu Val Val Val Trp Thr Arg Arg Ser 
        35                  40                  45


Arg Arg Lys Ser Ser Lys Ala His Ser Trp Gln Pro Gly Ile Lys Asn 
    50                  55                  60


Pro Tyr Arg Gly Val Val Val Trp Pro Val Pro Glu Asn Ile Glu Ile 
65                  70                  75                  80


Thr Val Thr Leu Phe Lys Asp Pro His Ala Glu Glu Phe Glu Asp Lys 
                85                  90                  95


Glu Trp Thr Phe Val Ile Glu Asn Glu Ser Pro Ser Gly Arg Arg Arg 
            100                 105                 110


Ala Leu Ala Thr Ser Ser Ile Asn Met Lys Gln Tyr Ala Ser Pro Met 
        115                 120                 125


Pro Thr Gln Thr Asp Val Lys Leu Lys Phe Lys Pro Leu Ser Lys Lys 
    130                 135                 140


Val Val Ser Ala Ala Leu Gln Phe Ser Leu Ser Cys Ile Phe Leu Arg 
145                 150                 155                 160


Glu Gly Lys Ala Thr Asp Glu Asp Met Gln Ser Leu Ala Ser Leu Met 
                165                 170                 175


Ser Met Lys Gln Ala Asp Ile Gly Asn Leu Asp Asp Phe Glu Glu Asp 
            180                 185                 190


Asn Glu Asp Asp Asp Glu Asn Arg Val Asn Gln Glu Glu Lys Ala Ala 
        195                 200                 205


Lys Ile Thr Gly Ile Val Asn Gln Leu Asn Ala Leu Ser Ser Leu Asp 
    210                 215                 220


Glu Asp Gln Asp Asp Cys Ile Lys Gln Ala Asn Met Arg Ser Ala Lys 
225                 230                 235                 240


Ser Ala Ser Ser Ser Glu Glu Leu Ile Asn Lys Leu Asn Phe Leu Val 
                245                 250                 255


Glu Ala Glu Lys Asp Leu Ala Thr Val Asn Ser Asn Pro Phe Asp Asp 
            260                 265                 270


Pro Asp Ala Ala Glu Leu Asn Pro Phe Gly Asp Pro Asp Ser Glu Glu 
        275                 280                 285


Pro Ile Thr Glu Thr Ala Ser Pro Arg Lys Thr Glu Asp Ser Phe Tyr 
    290                 295                 300


Asn Asn Ser Tyr Asn Pro Phe Lys Glu Val Gln Thr Pro Gln Tyr Leu 
305                 310                 315                 320


Asn Pro Phe Asp Glu Pro Glu Ala Phe Val Thr Ile Lys Asp Ser Pro 
                325                 330                 335


Pro Gln Ser Thr Lys Gly Lys Asn Ile Arg Pro Val Asp Met Ser Lys 
            340                 345                 350


Tyr Leu Tyr Ala Asp Ser Ser Lys Thr Glu Glu Glu Glu Leu Asp Glu 
        355                 360                 365


Ser Asn Pro Phe Tyr Glu Pro Lys Ser Thr Pro Pro Pro Asn Asn Leu 
    370                 375                 380


Val Asn Pro Val Gln Glu Leu Glu Thr Glu Arg Arg Val Lys Arg Lys 
385                 390                 395                 400


Ala Pro Ala Pro Pro Val Leu Ser Pro Lys Thr Gly Val Leu Asn Glu 
                405                 410                 415


Asn Thr Val Ser Ala Gly Lys Asp Leu Ser Thr Ser Pro Lys Pro Ser 
            420                 425                 430


Pro Ile Pro Ser Pro Val Leu Gly Arg Lys Pro Asn Ala Ser Gln Ser 
        435                 440                 445


Leu Leu Val Trp Cys Lys Glu Val Thr Lys Asn Tyr Arg Gly Val Lys 
    450                 455                 460


Ile Thr Asn Phe Thr Thr Ser Trp Arg Asn Gly Leu Ser Phe Cys Ala 
465                 470                 475                 480


Ile Leu His His Phe Arg Pro Asp Leu Ile Asp Tyr Lys Ser Leu Asn 
                485                 490                 495


Pro Gln Asp Ile Lys Glu Asn Asn Lys Lys Ala Tyr Asp Gly Phe Ala 
            500                 505                 510


Ser Ile Gly Ile Ser Arg Leu Leu Glu Pro Ser Asp Met Val Leu Leu 
        515                 520                 525


Ala Ile Pro Asp Lys Leu Thr Val Met Thr Tyr Leu Tyr Gln Ile Arg 
    530                 535                 540


Ala His Phe Ser Gly Gln Glu Leu Asn Val Val Gln Ile Glu Glu Asn 
545                 550                 555                 560


Ser Ser Lys Ser Thr Tyr Lys Val Gly Asn Tyr Glu Thr Asp Thr Asn 
                565                 570                 575


Ser Ser Val Asp Gln Glu Lys Phe Tyr Ala Glu Leu Ser Asp Leu Lys 
            580                 585                 590


Arg Glu Pro Glu Leu Gln Gln Pro Ile Ser Gly Ala Val Asp Phe Leu 
        595                 600                 605


Ser Gln Asp Asp Ser Val Phe Val Asn Asp Ser Gly Val Gly Glu Ser 
    610                 615                 620


Glu Ser Glu His Gln Thr Pro Asp Asp His Leu Ser Pro Ser Thr Ala 
625                 630                 635                 640


Ser Pro Tyr Cys Arg Arg Thr Lys Ser Asp Thr Glu Pro Gln Lys Ser 
                645                 650                 655


Gln Gln Ser Ser Gly Arg Thr Ser Gly Ser Asp Asp Pro Gly Ile Cys 
            660                 665                 670


Ser Asn Thr Asp Ser Thr Gln Ala Gln Val Leu Leu Gly Lys Lys Arg 
        675                 680                 685


Leu Leu Lys Ala Glu Thr Leu Glu Leu Ser Asp Leu Tyr Val Ser Asp 
    690                 695                 700


Lys Lys Lys Asp Met Ser Pro Pro Phe Ile Cys Glu Glu Thr Asp Glu 
705                 710                 715                 720


Gln Lys Leu Gln Thr Leu Asp Ile Gly Ser Asn Leu Glu Lys Glu Lys 
                725                 730                 735


Leu Glu Asn Ser Arg Ser Leu Glu Cys Arg Ser Asp Pro Glu Ser Pro 
            740                 745                 750


Ile Lys Lys Thr Ser Leu Ser Pro Thr Ser Lys Leu Gly Tyr Ser Tyr 
        755                 760                 765


Ser Arg Asp Leu Asp Leu Ala Lys Lys Lys His Ala Ser Leu Arg Gln 
    770                 775                 780


Thr Glu Ser Asp Pro Asp Ala Asp Arg Thr Thr Leu Asn His Ala Asp 
785                 790                 795                 800


His Ser Ser Lys Ile Val Gln His Arg Leu Leu Ser Arg Gln Glu Glu 
                805                 810                 815


Leu Lys Glu Arg Ala Arg Val Leu Leu Glu Gln Ala Arg Arg Asp Ala 
            820                 825                 830


Ala Leu Lys Ala Gly Asn Lys His Asn Thr Asn Thr Ala Thr Pro Phe 
        835                 840                 845


Cys Asn Arg Gln Leu Ser Asp Gln Gln Asp Glu Glu Arg Arg Arg Gln 
    850                 855                 860


Leu Arg Glu Arg Ala Arg Gln Leu Ile Ala Glu Ala Arg Ser Gly Val 
865                 870                 875                 880


Lys Met Ser Glu Leu Pro Ser Tyr Gly Glu Met Ala Ala Glu Lys Leu 
                885                 890                 895


Lys Glu Arg Ser Lys Ala Ser Gly Asp Glu Asn Asp Asn Ile Glu Ile 
            900                 905                 910


Asp Thr Asn Glu Glu Ile Pro Glu Gly Phe Val Val Gly Gly Gly Asp 
        915                 920                 925


Glu Leu Thr Asn Leu Glu Asn Asp Leu Asp Thr Pro Glu Gln Asn Ser 
    930                 935                 940


Lys Leu Val Asp Leu Lys Leu Lys Lys Leu Leu Glu Val Gln Pro Gln 
945                 950                 955                 960


Val Ala Asn Ser Pro Ser Ser Ala Ala Gln Lys Ala Val Thr Glu Ser 
                965                 970                 975


Ser Glu Gln Asp Met Lys Ser Gly Thr Glu Asp Leu Arg Thr Glu Arg 
            980                 985                 990


Leu Gln Lys Thr Thr Glu Arg Phe Arg Asn Pro Val Val Phe Ser Lys 
        995                 1000                1005


Asp Ser Thr Val Arg Lys Thr Gln Leu Gln Ser Phe Ser Gln Tyr Ile 
    1010                1015                1020


Glu Asn Arg Pro Glu Met Lys Arg Gln Arg Ser Ile Gln Glu Asp Thr 
1025                1030                1035                1040


Lys Lys Gly Asn Glu Glu Lys Ala Ala Ile Thr Glu Thr Gln Arg Lys 
                1045                1050                1055


Pro Ser Glu Asp Glu Val Leu Asn Lys Gly Phe Lys Asp Thr Ser Gln 
            1060                1065                1070


Tyr Val Val Gly Glu Leu Ala Ala Leu Glu Asn Glu Gln Lys Gln Ile 
        1075                1080                1085


Asp Thr Arg Ala Ala Leu Val Glu Lys Arg Leu Arg Tyr Leu Met Asp 
    1090                1095                1100


Thr Gly Arg Asn Thr Glu Glu Glu Glu Ala Met Met Gln Glu Trp Phe 
1105                1110                1115                1120


Met Leu Val Asn Lys Lys Asn Ala Leu Ile Arg Arg Met Asn Gln Leu 
                1125                1130                1135


Ser Leu Leu Glu Lys Glu His Asp Leu Glu Arg Arg Tyr Glu Leu Leu 
            1140                1145                1150


Asn Arg Glu Leu Arg Ala Met Leu Ala Ile Glu Asp Trp Gln Lys Thr 
        1155                1160                1165


Glu Ala Gln Lys Arg Arg Glu Gln Leu Leu Leu Asp Glu Leu Val Ala 
    1170                1175                1180


Leu Val Asn Lys Arg Asp Ala Leu Val Arg Asp Leu Asp Ala Gln Glu 
1185                1190                1195                1200


Lys Gln Ala Glu Glu Glu Asp Glu His Leu Glu Arg Thr Leu Glu Gln 
                1205                1210                1215


Asn Lys Gly Lys Met Ala Lys Lys Glu Glu Lys Cys Val Leu Gln 
            1220                1225                1230


<210>  157
<211>  636
<212>  DNA
<213>  Homo sapiens

<400>  157
atgccgacga gcaagcaggt aagtggcggc gccctcccag tgggtgctct tcccaggcgc     60

gagagtccgg aggggccgag gagagatctg cacgcccgga gctgctcccg cgctctgcaa    120

agtagcctgc gccggcacga gcagcccgcg gcgtcggtct caggtggcgg cgccggggaa    180

gaaaacgctg gggcccgcgg cgccgggaga ggggccgagg cccgggctcc tccagcccgc    240

cgcccccggg tcctggcgcc cacacccgag cggctgagcc ctgtagcgcg cgggagagcg    300

aaggaaccgg ttctccagca cctcgcctcc tccctgccac tccctccgga gcgccgagag    360

cgcgagaagg gcgggggcgc ccagggcagg cctggagacc cacggccccc tccgcggcca    420

ggactcgggc tctccgctcg ccttcctcgc ctagctctgc gccgcttttg ccagccgagt    480

cccggagact tcccagtccc cactgcctcc acgttgcacc gggagtgccg cggcaacgcc    540

gagccacctc ccaactctgc ccctcgaatt cccccccttg cggcccctcg gcgcgatccc    600

aggcgaggca atgtcctgag aacgtgtggg gcttag                              636


<210>  158
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  158

Met Pro Thr Ser Lys Gln Val Ser Gly Gly Ala Leu Pro Val Gly Ala 
1               5                   10                  15


Leu Pro Arg Arg Glu Ser Pro Glu Gly Pro Arg Arg Asp Leu His Ala 
            20                  25                  30


Arg Ser Cys Ser Arg Ala Leu Gln Ser Ser Leu Arg Arg His Glu Gln 
        35                  40                  45


Pro Ala Ala Ser Val Ser Gly Gly Gly Ala Gly Glu Glu Asn Ala Gly 
    50                  55                  60


Ala Arg Gly Ala Gly Arg Gly Ala Glu Ala Arg Ala Pro Pro Ala Arg 
65                  70                  75                  80


Arg Pro Arg Val Leu Ala Pro Thr Pro Glu Arg Leu Ser Pro Val Ala 
                85                  90                  95


Arg Gly Arg Ala Lys Glu Pro Val Leu Gln His Leu Ala Ser Ser Leu 
            100                 105                 110


Pro Leu Pro Pro Glu Arg Arg Glu Arg Glu Lys Gly Gly Gly Ala Gln 
        115                 120                 125


Gly Arg Pro Gly Asp Pro Arg Pro Pro Pro Arg Pro Gly Leu Gly Leu 
    130                 135                 140


Ser Ala Arg Leu Pro Arg Leu Ala Leu Arg Arg Phe Cys Gln Pro Ser 
145                 150                 155                 160


Pro Gly Asp Phe Pro Val Pro Thr Ala Ser Thr Leu His Arg Glu Cys 
                165                 170                 175


Arg Gly Asn Ala Glu Pro Pro Pro Asn Ser Ala Pro Arg Ile Pro Pro 
            180                 185                 190


Leu Ala Ala Pro Arg Arg Asp Pro Arg Arg Gly Asn Val Leu Arg Thr 
        195                 200                 205


Cys Gly Ala 
    210


<210>  159
<211>  2176
<212>  DNA
<213>  Homo sapiens

<400>  159
gatcaatctt catcaggcta catttccaat cacctaaaca accgagcaag acaagccact     60

ccgacaaggt tggctgcccg gcgggtctct gtgagagatc caggtagatg gtgaacggcc    120

ccggcagctg agggcaggcc aggcccccag acgcatcaga ccctgaagga ctgcgtggtg    180

ggagccctgc accgctcctg gccccgggcc ccctggatcc gtcggggcgc ctccacccag    240

ctgttagcat gatgtcttac ctcaaacaac ccccatacgg catgaacggg ctgggcctgg    300

ccgggcccgc catggacctc ctgcacccat ccgtgggcta tccggccact ccgcggaagc    360

agcggcggga gcgcaccacc ttcacgcgtt cacagctgga cgtgctcgag gcgctcttcg    420

ccaagactcg ctaccctgac atcttcatgc gggaggaggt ggcgctcaag atcaacctgc    480

cggagtctag agtccaggtc tggttcaaga accgccgcgc caaatgccgc cagcagcagc    540

agagcgggag cggaaccaag agccgcccag ccaagaagaa gtcctctcca gtgcgggaga    600

gctcgggctc cgaaagcagt ggccaattca cgccgccagc tgtgtccagc tctgcctcgt    660

cctctagctc ggcgtccagc tcttccgcca acccagcggc tgcagcggct gcgggactag    720

gtgggaaccc ggtggcggcc gcgtcgtcgc tgagtacacc agctgcctca tctatctgga    780

gcccggcctc catctcgcca ggctcagcgc ccgcgtccgt gtcggtgccg gagccattgg    840

ccgcgcctag caacacctcg tgtatgcagc gctccgtagc tgcaggcgcc gccaccgcag    900

cagcctctta tcccatgtcc tacggccagg gcggcagcta cggccaaggc taccctacgc    960

cctcctcttc ctactttggc ggcgtggact gcagctcata cctagcgccc atgcactcac   1020

atcaccaccc gcaccagctc agccccatgg caccctcctc catggcgggc caccatcatc   1080

accacccaca tgcgcaccac ccgttgagcc agtcctcagg ccaccaccac caccatcacc   1140

accaccacca ccaaggctac ggtggctctg ggcttgcctt caactctgcc gactgcttgg   1200

attacaagga gcctggcgcc gctgctgctt cctccgcctg gaaactcaac ttcaactccc   1260

ccgactgtct ggactataag gaccaagcct catggcggtt ccaggtcttg tgagcccagg   1320

aatgaaagag gagaagaaac gcaactacct gcgccctccg tggtcccgat cctgttgctg   1380

ctgctgcacc gcccgccttt gcctcgtctt ctccaaaact gaattttcac cccccaaaaa   1440

gatgtccatt gcctgcactg ccgcccccat ttttgtgcca cttgcttggg gggatgtgca   1500

aacccaccct gccccttgga tggggggacc ggtgcttcgg cttggcctac acattctata   1560

caggagagat gtattatttc cccccttcag cccctactaa actcttaagc ctccccttcc   1620

agtctttctg gacagctatt aagcacttgc agccttcgga ggctctgcgc tctgatccgc   1680

tgtttgagcc caacacttta atttattctt tctggacact ggagtcacta actggcgtgt   1740

ttctgcccat tggagcaccc gcacactact ccaaatcaaa accactaaga gttcctcccg   1800

cgcagactgc tgccccttca gctgccctcg attttgctcc acgcctgccg gccagagcct   1860

cccggcgttt cttccgcccc agcggagtgc gctggggcgc gccagggcta ggcccgccgg   1920

aggagcgcgt ccccagcctt ccgcgcacag agccgcatcc cgccccgccc tgcgctggac   1980

tggttcaagc ttccgcctcg gcgggaacgc tgtacatagt caggtccgtt ccagggacca   2040

cttaaacttt ttagttgctg ttggttggtt gaactgaaca tatcttgtct tagcacccag   2100

gaaacagaac tttaagatat atacagcaca tatatatata tatacatata tatatacaca   2160

tatataaaaa acaaaa                                                   2176


<210>  160
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  160

Met Met Ser Tyr Leu Lys Gln Pro Pro Tyr Gly Met Asn Gly Leu Gly 
1               5                   10                  15


Leu Ala Gly Pro Ala Met Asp Leu Leu His Pro Ser Val Gly Tyr Pro 
            20                  25                  30


Ala Thr Pro Arg Lys Gln Arg Arg Glu Arg Thr Thr Phe Thr Arg Ser 
        35                  40                  45


Gln Leu Asp Val Leu Glu Ala Leu Phe Ala Lys Thr Arg Tyr Pro Asp 
    50                  55                  60


Ile Phe Met Arg Glu Glu Val Ala Leu Lys Ile Asn Leu Pro Glu Ser 
65                  70                  75                  80


Arg Val Gln Val Trp Phe Lys Asn Arg Arg Ala Lys Cys Arg Gln Gln 
                85                  90                  95


Gln Gln Ser Gly Ser Gly Thr Lys Ser Arg Pro Ala Lys Lys Lys Ser 
            100                 105                 110


Ser Pro Val Arg Glu Ser Ser Gly Ser Glu Ser Ser Gly Gln Phe Thr 
        115                 120                 125


Pro Pro Ala Val Ser Ser Ser Ala Ser Ser Ser Ser Ser Ala Ser Ser 
    130                 135                 140


Ser Ser Ala Asn Pro Ala Ala Ala Ala Ala Ala Gly Leu Gly Gly Asn 
145                 150                 155                 160


Pro Val Ala Ala Ala Ser Ser Leu Ser Thr Pro Ala Ala Ser Ser Ile 
                165                 170                 175


Trp Ser Pro Ala Ser Ile Ser Pro Gly Ser Ala Pro Ala Ser Val Ser 
            180                 185                 190


Val Pro Glu Pro Leu Ala Ala Pro Ser Asn Thr Ser Cys Met Gln Arg 
        195                 200                 205


Ser Val Ala Ala Gly Ala Ala Thr Ala Ala Ala Ser Tyr Pro Met Ser 
    210                 215                 220


Tyr Gly Gln Gly Gly Ser Tyr Gly Gln Gly Tyr Pro Thr Pro Ser Ser 
225                 230                 235                 240


Ser Tyr Phe Gly Gly Val Asp Cys Ser Ser Tyr Leu Ala Pro Met His 
                245                 250                 255


Ser His His His Pro His Gln Leu Ser Pro Met Ala Pro Ser Ser Met 
            260                 265                 270


Ala Gly His His His His His Pro His Ala His His Pro Leu Ser Gln 
        275                 280                 285


Ser Ser Gly His His His His His His His His His His Gln Gly Tyr 
    290                 295                 300


Gly Gly Ser Gly Leu Ala Phe Asn Ser Ala Asp Cys Leu Asp Tyr Lys 
305                 310                 315                 320


Glu Pro Gly Ala Ala Ala Ala Ser Ser Ala Trp Lys Leu Asn Phe Asn 
                325                 330                 335


Ser Pro Asp Cys Leu Asp Tyr Lys Asp Gln Ala Ser Trp Arg Phe Gln 
            340                 345                 350


Val Leu 



<210>  161
<211>  3310
<212>  DNA
<213>  Homo sapiens

<400>  161
ctcaggagga aaggacctgc ctgatggagc ccggcaattg gcgggagaga tagcgtgtgt     60

aactctaggg aggggagaat caccccttag cgacatcacc cccacgcgcg tgactgagac    120

tgcatcctcc catgagggta aacgtgggag gtaaagagac cttccgctgc gtaaagctgg    180

atcgacccgg aaacaaaatc ttttaaaaaa cgattgacac tctggagggg cgggggaatt    240

gataagttgg gacgaccgga cagcttctca ggttgctaag cgacgaggcg ggagcgcacg    300

cacaccctgg ctgctttgta gcacctgagg aaactgtggc ggcggcggcg gcgtcctgga    360

gacccaagag accaagcgag cgtgtcgctc cctctcgggt ccgaggacct agcctaggaa    420

ccttctgccc ggggtagtgt ctggtgatga ggcgagagtt ttgctgggac gcctactcca    480

aagcggccgg gagtcgcgct tcttccccac tcccgagaca ggatagagat tccttctgcc    540

atcagatgtc tttctgcttg actgaactgc acctgtggtc tttgaagaat accttacaca    600

ttgcggatag agacattggg atctaccagt attatgacaa gaaagatcca ccagcgacag    660

agcatggtaa cttagaaaag aagcagaagc tggcagagtc acgagattat ccttggacgc    720

tcaaaaacag acgcccagaa aaactccgag actcgctcaa agagttggag gagctgatgc    780

aaaacagtcg gtgtgtgctg agcaaatgga agaacaaata tgtctgtcag ctcctttttg    840

gttcaggtgt gctggtgtct ctaagccttt ctgggccgca gctggagaaa gtggtgattg    900

acagaagcct ggtggggaag ctcatctcag acaccatcag tgatgctctt ctcacagaca    960

gttttatcat cttatcattt ttggcacaaa acaaactatg ttttattcag tttaccaaga   1020

agatggagtc ttctgatgta aacaaaagac tggaaaaact ctcagccttg gattataaga   1080

ttttctatta tgaaataccc ggcccaataa acaagacaac agagcgacat ctagctatca   1140

actgtgttca tgatagagtt gtttgctggt ggccactggt caacgatgat gcttggcctt   1200

gggcccccat ttcttctgag aaggacagag ccaatctact cctcctgggt tatgctcaag   1260

gaagactaga ggttctgagt tctgtccgca cagaatggga cccactggat gttcgctttg   1320

gcaccaaaca gccttatcag gtgttcacag tggagcactc cgtaagtgta gacaaagagc   1380

ccatggctga cagctgcatc tatgaatgca ttcggaataa aatccagtgt gtgtcagtca   1440

ccagaatacc actaaagtca aaggccatca gctgctgcag gaatgttact gaagacaaac   1500

tgattctggg ctgtgaagat tcttcgctaa ttctttatga aactcaccgt agagtgactc   1560

tcttagcaca gactgaactt ttgccttcat taataagctg ccacccaagt ggtgccattc   1620

tgctagttgg cagcaaccaa ggggagttgc aaatttttga tatggctcta tcccctatta   1680

acatccaact gttggctgaa gaccgcttac ccagggagac tctgcaattc agtaaattat   1740

ttgatgcctc cagcagtctt gttcaaatgc aatggatagc tcctcaggtt gtttctcaga   1800

agggtgaagg tagtgatatc tatgatctcc tcttcctcag gtttgaaaga ggacctttgg   1860

gtgtgctgtt gtttaaacta ggcgtcttca ctcgaggaca gctgggcctg atagacatca   1920

tcttccagta cattcactgt gatgagatct atgaggcaat aaacatcctg agcagcatga   1980

actgggacac tctgggccac cagtgcttta tcagcatgag cgccattgta aaccatcttc   2040

ttagacagaa gctcactcca gagagagaag cacagcttga gacaagcctt ggaaccttct   2100

atgctccaac aagaccactt ctggattcca ctatattgga atatagagat caaatcagca   2160

aatatgcaag gagattcttc catcacttgc tcaggtacca gaggtttgaa aaggcatttc   2220

tcctagctgt tgacgttggt gctcgtgacc tctttatgga tattcattac cttgcactag   2280

ataaaggtga attggcacta gctgaagtgg caagaaaaag agctagtgac attgatgcag   2340

aatcaataac ctctggggtt gaactcctgg gacccttgga cagaggggat atgctaaatg   2400

aagcatttat tggcctgtct ttagcacctc aaggagaaga ctcatttcca gataacctcc   2460

ctccctcttg cccaacccac agacatattt tacaacaaag aatactgaat ggctcttcta   2520

acagacaaat aattgacaga aggaatgaac ttgaaaaaga catctgttct ggatttttga   2580

tgactaatac ctgtaatgca gaagacggag aactgagaga agacggcaga gaacaggaaa   2640

tcagagatgg tggttctctc aaaatgattc actttggtct ggtgtaaaca ttaagaaaaa   2700

aagaaaactg ccttcttcat atctaaactt ttcatggcct gatacagact taaaatcccc   2760

cgtgtggatt tttaacaaga gacagtatga atcatataaa ttagttaaga gttttgagtt   2820

gagtgtttgt tttcaaaata aagttttatt atttcaaaaa catgcagcat aacagcaaag   2880

tgatcgtaag taaaagtctt caacctactt attttcaata atgtaaaatt ttgaaagtgt   2940

cttaaattgt atgttaatta ggtgctacaa aaatagaata tttaaacttt gttctcccag   3000

gtactttaaa aaaggggcag tagggggcag gcatagtgct catgcctgta gtcccagtgc   3060

tttaggaggc caaggctgaa ggatcacttg agcccaggag ttcaagacta gcctgtgcaa   3120

catagtgaaa cgctgtctct agaaaaaatt ttaaaaatta gccaggcatg gtggtacatg   3180

cttgtgaagc tgaggcagaa gaattgcttg agcccaggag ttcaaggcta cagtgagctg   3240

tgatcgcgcc actgcactct aacctgggca acagagagtg accctgtctc caaaaaaaaa   3300

aaaaaaaaaa                                                          3310


<210>  162
<211>  746
<212>  PRT
<213>  Homo sapiens

<400>  162

Met Arg Arg Glu Phe Cys Trp Asp Ala Tyr Ser Lys Ala Ala Gly Ser 
1               5                   10                  15


Arg Ala Ser Ser Pro Leu Pro Arg Gln Asp Arg Asp Ser Phe Cys His 
            20                  25                  30


Gln Met Ser Phe Cys Leu Thr Glu Leu His Leu Trp Ser Leu Lys Asn 
        35                  40                  45


Thr Leu His Ile Ala Asp Arg Asp Ile Gly Ile Tyr Gln Tyr Tyr Asp 
    50                  55                  60


Lys Lys Asp Pro Pro Ala Thr Glu His Gly Asn Leu Glu Lys Lys Gln 
65                  70                  75                  80


Lys Leu Ala Glu Ser Arg Asp Tyr Pro Trp Thr Leu Lys Asn Arg Arg 
                85                  90                  95


Pro Glu Lys Leu Arg Asp Ser Leu Lys Glu Leu Glu Glu Leu Met Gln 
            100                 105                 110


Asn Ser Arg Cys Val Leu Ser Lys Trp Lys Asn Lys Tyr Val Cys Gln 
        115                 120                 125


Leu Leu Phe Gly Ser Gly Val Leu Val Ser Leu Ser Leu Ser Gly Pro 
    130                 135                 140


Gln Leu Glu Lys Val Val Ile Asp Arg Ser Leu Val Gly Lys Leu Ile 
145                 150                 155                 160


Ser Asp Thr Ile Ser Asp Ala Leu Leu Thr Asp Ser Phe Ile Ile Leu 
                165                 170                 175


Ser Phe Leu Ala Gln Asn Lys Leu Cys Phe Ile Gln Phe Thr Lys Lys 
            180                 185                 190


Met Glu Ser Ser Asp Val Asn Lys Arg Leu Glu Lys Leu Ser Ala Leu 
        195                 200                 205


Asp Tyr Lys Ile Phe Tyr Tyr Glu Ile Pro Gly Pro Ile Asn Lys Thr 
    210                 215                 220


Thr Glu Arg His Leu Ala Ile Asn Cys Val His Asp Arg Val Val Cys 
225                 230                 235                 240


Trp Trp Pro Leu Val Asn Asp Asp Ala Trp Pro Trp Ala Pro Ile Ser 
                245                 250                 255


Ser Glu Lys Asp Arg Ala Asn Leu Leu Leu Leu Gly Tyr Ala Gln Gly 
            260                 265                 270


Arg Leu Glu Val Leu Ser Ser Val Arg Thr Glu Trp Asp Pro Leu Asp 
        275                 280                 285


Val Arg Phe Gly Thr Lys Gln Pro Tyr Gln Val Phe Thr Val Glu His 
    290                 295                 300


Ser Val Ser Val Asp Lys Glu Pro Met Ala Asp Ser Cys Ile Tyr Glu 
305                 310                 315                 320


Cys Ile Arg Asn Lys Ile Gln Cys Val Ser Val Thr Arg Ile Pro Leu 
                325                 330                 335


Lys Ser Lys Ala Ile Ser Cys Cys Arg Asn Val Thr Glu Asp Lys Leu 
            340                 345                 350


Ile Leu Gly Cys Glu Asp Ser Ser Leu Ile Leu Tyr Glu Thr His Arg 
        355                 360                 365


Arg Val Thr Leu Leu Ala Gln Thr Glu Leu Leu Pro Ser Leu Ile Ser 
    370                 375                 380


Cys His Pro Ser Gly Ala Ile Leu Leu Val Gly Ser Asn Gln Gly Glu 
385                 390                 395                 400


Leu Gln Ile Phe Asp Met Ala Leu Ser Pro Ile Asn Ile Gln Leu Leu 
                405                 410                 415


Ala Glu Asp Arg Leu Pro Arg Glu Thr Leu Gln Phe Ser Lys Leu Phe 
            420                 425                 430


Asp Ala Ser Ser Ser Leu Val Gln Met Gln Trp Ile Ala Pro Gln Val 
        435                 440                 445


Val Ser Gln Lys Gly Glu Gly Ser Asp Ile Tyr Asp Leu Leu Phe Leu 
    450                 455                 460


Arg Phe Glu Arg Gly Pro Leu Gly Val Leu Leu Phe Lys Leu Gly Val 
465                 470                 475                 480


Phe Thr Arg Gly Gln Leu Gly Leu Ile Asp Ile Ile Phe Gln Tyr Ile 
                485                 490                 495


His Cys Asp Glu Ile Tyr Glu Ala Ile Asn Ile Leu Ser Ser Met Asn 
            500                 505                 510


Trp Asp Thr Leu Gly His Gln Cys Phe Ile Ser Met Ser Ala Ile Val 
        515                 520                 525


Asn His Leu Leu Arg Gln Lys Leu Thr Pro Glu Arg Glu Ala Gln Leu 
    530                 535                 540


Glu Thr Ser Leu Gly Thr Phe Tyr Ala Pro Thr Arg Pro Leu Leu Asp 
545                 550                 555                 560


Ser Thr Ile Leu Glu Tyr Arg Asp Gln Ile Ser Lys Tyr Ala Arg Arg 
                565                 570                 575


Phe Phe His His Leu Leu Arg Tyr Gln Arg Phe Glu Lys Ala Phe Leu 
            580                 585                 590


Leu Ala Val Asp Val Gly Ala Arg Asp Leu Phe Met Asp Ile His Tyr 
        595                 600                 605


Leu Ala Leu Asp Lys Gly Glu Leu Ala Leu Ala Glu Val Ala Arg Lys 
    610                 615                 620


Arg Ala Ser Asp Ile Asp Ala Glu Ser Ile Thr Ser Gly Val Glu Leu 
625                 630                 635                 640


Leu Gly Pro Leu Asp Arg Gly Asp Met Leu Asn Glu Ala Phe Ile Gly 
                645                 650                 655


Leu Ser Leu Ala Pro Gln Gly Glu Asp Ser Phe Pro Asp Asn Leu Pro 
            660                 665                 670


Pro Ser Cys Pro Thr His Arg His Ile Leu Gln Gln Arg Ile Leu Asn 
        675                 680                 685


Gly Ser Ser Asn Arg Gln Ile Ile Asp Arg Arg Asn Glu Leu Glu Lys 
    690                 695                 700


Asp Ile Cys Ser Gly Phe Leu Met Thr Asn Thr Cys Asn Ala Glu Asp 
705                 710                 715                 720


Gly Glu Leu Arg Glu Asp Gly Arg Glu Gln Glu Ile Arg Asp Gly Gly 
                725                 730                 735


Ser Leu Lys Met Ile His Phe Gly Leu Val 
            740                 745


<210>  163
<211>  6907
<212>  DNA
<213>  Homo sapiens

<400>  163
ccgcccagcc aggtgcaaaa tgccgtgtca ttgggagact ccgcagccgg agcattagat     60

tacagctcga cggagctcgg gaagggcggc gggggtggaa gatgagcaga agcccctgtt    120

ctcggaacgc cggctgacaa gcggggtgag cgcagccggg gcggggaccc agcctagccc    180

actggagcag ccgggggtgg cccgttcccc tttaagagca actgctctaa gccaggagcc    240

agagattcga gccggcctcg cccagccagc cctctccagc gaggggaccc acaagcggcg    300

cctcggccct cccgaccttt ccgagccctc tttgcgccct gggcgcacgg ggccctacac    360

gcgccaagca tgctgagggt cttcatcctc tatgccgaga acgtccacac acccgacacc    420

gacatcagcg atgcctactg ctccgcggtg tttgcagggg tgaagaagag aaccaaagtc    480

atcaagaaca gcgtgaaccc tgtatggaat gagggatttg aatgggacct caagggcatc    540

cccctggacc agggctctga gcttcatgtg gtggtcaaag accatgagac gatggggagg    600

aacaggttcc tgggggaagc caaggtccca ctccgagagg tcctcgccac ccctagtctg    660

tccgccagct tcaatgcccc cctgctggac accaagaagc agcccacagg ggcctcgctg    720

gtcctgcagg tgtcctacac accgctgcct ggagctgtgc ccctgttccc gccccctact    780

cctctggagc cctccccgac tctgcctgac ctggatgtag tggcagacac aggaggagag    840

gaagacacag aggaccaggg actcactgga gatgaggcgg agccattcct ggatcaaagc    900

ggaggcccgg gggctcccac caccccaagg aaactacctt cacgtcctcc gccccactac    960

cccgggatca aaagaaagcg aagtgcgcct acatctagaa agctgctgtc agacaaaccg   1020

caggatttcc agatcagggt ccaggtgatc gaggggcgcc agctgccggg ggtgaacatc   1080

aagcctgtgg tcaaggttac cgctgcaggg cagaccaagc ggacgcggat ccacaaggga   1140

aacagcccac tcttcaatga gactcttttc ttcaacttgt ttgactctcc tggggagctg   1200

tttgatgagc ccatctttat cacggtggta gactctcgtt ctctcaggac agatgctctc   1260

ctcggggagt tccggatgga cgtgggcacc atttacagag agccccggca cgcctatctc   1320

aggaagtggc tgctgctctc agaccctgat gacttctctg ctggggccag aggctacctg   1380

aaaacaagcc tttgtgtgct ggggcctggg gacgaagcgc ctctggagag aaaagacccc   1440

tctgaagaca aggaggacat tgaaagcaac ctgctccggc ccacaggcgt agccctgcga   1500

ggagcccact tctgcctgaa ggtcttccgg gccgaggact tgccgcagat ggacgatgcc   1560

gtgatggaca acgtgaaaca gatctttggc ttcgagagta acaagaagaa cttggtggac   1620

ccctttgtgg aggtcagctt tgcggggaaa atgctgtgca gcaagatctt ggagaagacg   1680

gccaaccctc agtggaacca gaacatcaca ctgcctgcca tgtttccctc catgtgcgaa   1740

aaaatgagga ttcgtatcat agactgggac cgcctgactc acaatgacat cgtggctacc   1800

acctacctga gtatgtcgaa aatctctgcc cctggaggag aaatagaaga ggagcctgca   1860

ggtgctgtca agccttcgaa agcctcagac ttggatgact acctgggctt cctccccact   1920

tttgggccct gctacatcaa cctctatggc agtcccagag agttcacagg cttcccagac   1980

ccctacacag agctcaacac aggcaagggg gaaggtgtgg cttatcgtgg ccggcttctg   2040

ctctccctgg agaccaagct ggtggagcac agtgaacaga aggtggagga ccttcctgcg   2100

gatgacatcc tccgggtgga gaagtacctt aggaggcgca agtactccct gtttgcggcc   2160

ttctactcag ccaccatgct gcaggatgtg gatgatgcca tccagtttga ggtcagcatc   2220

gggaactacg ggaacaagtt cgacatgacc tgcctgccgc tggcctccac cactcagtac   2280

agccgtgcag tctttgacgg gtgccactac tactacctac cctggggtaa cgtgaaacct   2340

gtggtggtgc tgtcatccta ctgggaggac atcagccata gaatcgagac tcagaaccag   2400

ctgcttggga ttgctgaccg gctggaagct ggcctggagc aggtccacct ggccctgaag   2460

gcgcagtgct ccacggagga cgtggactcg ctggtggctc agctgacgga tgagctcatc   2520

gcaggctgca gccagcctct gggtgacatc catgagacac cctctgccac ccacctggac   2580

cagtacctgt accagctgcg cacccatcac ctgagccaaa tcactgaggc tgccctggcc   2640

ctgaagctcg gccacagtga gctccctgca gctctggagc aggcggagga ctggctcctg   2700

cgtctgcgtg ccctggcaga ggagccccag aacagcctgc cggacatcgt catctggatg   2760

ctgcagggag acaagcgtgt ggcataccag cgggtgcccg cccaccaagt cctcttctcc   2820

cggcggggtg ccaactactg tggcaagaat tgtgggaagc tacagacaat ctttctgaaa   2880

tatccgatgg agaaggtgcc tggcgcccgg atgccagtgc agatacgggt caagctgtgg   2940

tttgggctct ctgtggatga gaaggagttc aaccagtttg ctgaggggaa gctgtctgtc   3000

tttgctgaaa cctatgagaa cgagactaag ttggcccttg ttgggaactg gggcacaacg   3060

ggcctcacct accccaagtt ttctgacgtc acgggcaaga tcaagctacc caaggacagc   3120

ttccgcccct cggccggctg gacctgggct ggagattggt tcgtgtgtcc ggagaagact   3180

ctgctccatg acatggacgc cggtcacctg agcttcgtgg aagaggtgtt tgagaaccag   3240

acccggcttc ccggaggcca gtggatctac atgagtgaca actacaccga tgtgaacggg   3300

gagaaggtgc ttcccaagga tgacattgag tgcccactgg gctggaagtg ggaagatgag   3360

gaatggtcca cagacctcaa ccgggctgtc gatgagcaag gctgggagta tagcatcacc   3420

atccccccgg agcggaagcc gaagcactgg gtccctgctg agaagatgta ctacacacac   3480

cgacggcggc gctgggtgcg cctgcgcagg agggatctca gccaaatgga agcactgaaa   3540

aggcacaggc aggcggaggc ggagggcgag ggctgggagt acgcctctct ttttggctgg   3600

aagttccacc tcgagtaccg caagacagat gccttccgcc gccgccgctg gcgccgtcgc   3660

atggagccac tggagaagac ggggcctgca gctgtgtttg cccttgaggg ggccctgggc   3720

ggcgtgatgg atgacaagag tgaagattcc atgtccgtct ccaccttgag cttcggtgtg   3780

aacagaccca cgatttcctg catattcgac tatgggaacc gctaccatct acgctgctac   3840

atgtaccagg cccgggacct ggctgcgatg gacaaggact ctttttctga tccctatgcc   3900

atcgtctcct tcctgcacca gagccagaag acggtggtgg tgaagaacac ccttaacccc   3960

acctgggacc agacgctcat cttctacgag atcgagatct ttggcgagcc ggccacagtt   4020

gctgagcaac cgcccagcat tgtggtggag ctgtacgacc atgacactta tggtgcagac   4080

gagtttatgg gtcgctgcat ctgtcaaccg agtctggaac ggatgccacg gctggcctgg   4140

ttcccactga cgaggggcag ccagccgtcg ggggagctgc tggcctcttt tgagctcatc   4200

cagagagaga agccggccat ccaccatatt cctggttttg aggtgcagga gacatcaagg   4260

atcctggatg agtctgagga cacagacctg ccctacccac caccccagag ggaggccaac   4320

atctacatgg ttcctcagaa catcaagcca gcgctccagc gtaccgccat cgagatcctg   4380

gcatggggcc tgcggaacat gaagagttac cagctggcca acatctcctc ccccagcctc   4440

gtggtagagt gtgggggcca gacggtgcag tcctgtgtca tcaggaacct ccggaagaac   4500

cccaactttg acatctgcac cctcttcatg gaagtgatgc tgcccaggga ggagctctac   4560

tgccccccca tcaccgtcaa ggtcatcgat aaccgccagt ttggccgccg gcctgtggtg   4620

ggccagtgta ccatccgctc cctggagagc ttcctgtgtg acccctactc ggcggagagt   4680

ccatccccac agggtggccc agacgatgtg agcctactca gtcctgggga agacgtgctc   4740

atcgacattg atgacaagga gcccctcatc cccatccagg aggaagagtt catcgattgg   4800

tggagcaaat tctttgcctc cataggggag agggaaaagt gcggctccta cctggagaag   4860

gattttgaca ccctgaaggt ctatgacaca cagctggaga atgtggaggc ctttgagggc   4920

ctgtctgact tttgtaacac cttcaagctg taccggggca agacgcagga ggagacagaa   4980

gatccatctg tgattggtga atttaagggc ctcttcaaaa tttatcccct cccagaagac   5040

ccagccatcc ccatgccccc aagacagttc caccagctgg ccgcccaggg accccaggag   5100

tgcttggtcc gtatctacat tgtccgagca tttggcctgc agcccaagga ccccaatgga   5160

aagtgtgatc cttacatcaa gatctccata gggaagaaat cagtgagtga ccaggataac   5220

tacatcccct gcacgctgga gcccgtattt ggaaagatgt tcgagctgac ctgcactctg   5280

cctctggaga aggacctaaa gatcactctc tatgactatg acctcctctc caaggacgaa   5340

aagatcggtg agacggtcgt cgacctggag aacaggctgc tgtccaagtt tggggctcgc   5400

tgtggactcc cacagaccta ctgtgtctct ggaccgaacc agtggcggga ccagctccgc   5460

ccctcccagc tcctccacct cttctgccag cagcatagag tcaaggcacc tgtgtaccgg   5520

acagaccgtg taatgtttca ggataaagaa tattccattg aagagataga ggctggcagg   5580

atcccaaacc cacacctggg cccagtggag gagcgtctgg ctctgcatgt gcttcagcag   5640

cagggcctgg tcccggagca cgtggagtca cggcccctct acagccccct gcagccagac   5700

atcgagcagg ggaagctgca gatgtgggtc gacctatttc cgaaggccct ggggcggcct   5760

ggacctccct tcaacatcac cccacggaga gccagaaggt ttttcctgcg ttgtattatc   5820

tggaatacca gagatgtgat cctggatgac ctgagcctca cgggggagaa gatgagcgac   5880

atttatgtga aaggttggat gattggcttt gaagaacaca agcaaaagac agacgtgcat   5940

tatcgttccc tgggaggtga aggcaacttc aactggaggt tcattttccc cttcgactac   6000

ctgccagctg agcaagtctg taccattgcc aagaaggatg ccttctggag gctggacaag   6060

actgagagca aaatcccagc acgagtggtg ttccagatct gggacaatga caagttctcc   6120

tttgatgatt ttctgggctc cctgcagctc gatctcaacc gcatgcccaa gccagccaag   6180

acagccaaga agtgctcctt ggaccagctg gatgatgctt tccacccaga atggtttgtg   6240

tccctttttg agcagaaaac agtgaagggc tggtggccct gtgtagcaga agagggtgag   6300

aagaaaatac tggcgggcaa gctggaaatg accttggaga ttgtagcaga gagtgagcat   6360

gaggagcggc ctgctggcca gggccgggat gagcccaaca tgaaccctaa gcttgaggac   6420

ccaaggcgcc ccgacacctc cttcctgtgg tttacctccc catacaagac catgaagttc   6480

atcctgtggc ggcgtttccg gtgggccatc atcctcttca tcatcctctt catcctgctg   6540

ctgttcctgg ccatcttcat ctacgccttc ccgaactatg ctgccatgaa gctggtgaag   6600

cccttcagct gaggactctc ctgccctgta gaaggggccg tggggtcccc tccagcatgg   6660

gactggcctg cctcctccgc ccagctcggc gagctcctcc agacctccta ggcctgattg   6720

tcctgccagg gtgggcagac agacagatgg accggcccac actcccagag ttgctaacat   6780

ggagctctga gatcacccca cttccatcat ttccttctcc cccaacccaa cgcttttttg   6840

gatcagctca gacatatttc agtataaaac agttggaacc acaaaaaaaa aaaaaaaaaa   6900

aaaaaaa                                                             6907


<210>  164
<211>  2080
<212>  PRT
<213>  Homo sapiens

<400>  164

Met Leu Arg Val Phe Ile Leu Tyr Ala Glu Asn Val His Thr Pro Asp 
1               5                   10                  15


Thr Asp Ile Ser Asp Ala Tyr Cys Ser Ala Val Phe Ala Gly Val Lys 
            20                  25                  30


Lys Arg Thr Lys Val Ile Lys Asn Ser Val Asn Pro Val Trp Asn Glu 
        35                  40                  45


Gly Phe Glu Trp Asp Leu Lys Gly Ile Pro Leu Asp Gln Gly Ser Glu 
    50                  55                  60


Leu His Val Val Val Lys Asp His Glu Thr Met Gly Arg Asn Arg Phe 
65                  70                  75                  80


Leu Gly Glu Ala Lys Val Pro Leu Arg Glu Val Leu Ala Thr Pro Ser 
                85                  90                  95


Leu Ser Ala Ser Phe Asn Ala Pro Leu Leu Asp Thr Lys Lys Gln Pro 
            100                 105                 110


Thr Gly Ala Ser Leu Val Leu Gln Val Ser Tyr Thr Pro Leu Pro Gly 
        115                 120                 125


Ala Val Pro Leu Phe Pro Pro Pro Thr Pro Leu Glu Pro Ser Pro Thr 
    130                 135                 140


Leu Pro Asp Leu Asp Val Val Ala Asp Thr Gly Gly Glu Glu Asp Thr 
145                 150                 155                 160


Glu Asp Gln Gly Leu Thr Gly Asp Glu Ala Glu Pro Phe Leu Asp Gln 
                165                 170                 175


Ser Gly Gly Pro Gly Ala Pro Thr Thr Pro Arg Lys Leu Pro Ser Arg 
            180                 185                 190


Pro Pro Pro His Tyr Pro Gly Ile Lys Arg Lys Arg Ser Ala Pro Thr 
        195                 200                 205


Ser Arg Lys Leu Leu Ser Asp Lys Pro Gln Asp Phe Gln Ile Arg Val 
    210                 215                 220


Gln Val Ile Glu Gly Arg Gln Leu Pro Gly Val Asn Ile Lys Pro Val 
225                 230                 235                 240


Val Lys Val Thr Ala Ala Gly Gln Thr Lys Arg Thr Arg Ile His Lys 
                245                 250                 255


Gly Asn Ser Pro Leu Phe Asn Glu Thr Leu Phe Phe Asn Leu Phe Asp 
            260                 265                 270


Ser Pro Gly Glu Leu Phe Asp Glu Pro Ile Phe Ile Thr Val Val Asp 
        275                 280                 285


Ser Arg Ser Leu Arg Thr Asp Ala Leu Leu Gly Glu Phe Arg Met Asp 
    290                 295                 300


Val Gly Thr Ile Tyr Arg Glu Pro Arg His Ala Tyr Leu Arg Lys Trp 
305                 310                 315                 320


Leu Leu Leu Ser Asp Pro Asp Asp Phe Ser Ala Gly Ala Arg Gly Tyr 
                325                 330                 335


Leu Lys Thr Ser Leu Cys Val Leu Gly Pro Gly Asp Glu Ala Pro Leu 
            340                 345                 350


Glu Arg Lys Asp Pro Ser Glu Asp Lys Glu Asp Ile Glu Ser Asn Leu 
        355                 360                 365


Leu Arg Pro Thr Gly Val Ala Leu Arg Gly Ala His Phe Cys Leu Lys 
    370                 375                 380


Val Phe Arg Ala Glu Asp Leu Pro Gln Met Asp Asp Ala Val Met Asp 
385                 390                 395                 400


Asn Val Lys Gln Ile Phe Gly Phe Glu Ser Asn Lys Lys Asn Leu Val 
                405                 410                 415


Asp Pro Phe Val Glu Val Ser Phe Ala Gly Lys Met Leu Cys Ser Lys 
            420                 425                 430


Ile Leu Glu Lys Thr Ala Asn Pro Gln Trp Asn Gln Asn Ile Thr Leu 
        435                 440                 445


Pro Ala Met Phe Pro Ser Met Cys Glu Lys Met Arg Ile Arg Ile Ile 
    450                 455                 460


Asp Trp Asp Arg Leu Thr His Asn Asp Ile Val Ala Thr Thr Tyr Leu 
465                 470                 475                 480


Ser Met Ser Lys Ile Ser Ala Pro Gly Gly Glu Ile Glu Glu Glu Pro 
                485                 490                 495


Ala Gly Ala Val Lys Pro Ser Lys Ala Ser Asp Leu Asp Asp Tyr Leu 
            500                 505                 510


Gly Phe Leu Pro Thr Phe Gly Pro Cys Tyr Ile Asn Leu Tyr Gly Ser 
        515                 520                 525


Pro Arg Glu Phe Thr Gly Phe Pro Asp Pro Tyr Thr Glu Leu Asn Thr 
    530                 535                 540


Gly Lys Gly Glu Gly Val Ala Tyr Arg Gly Arg Leu Leu Leu Ser Leu 
545                 550                 555                 560


Glu Thr Lys Leu Val Glu His Ser Glu Gln Lys Val Glu Asp Leu Pro 
                565                 570                 575


Ala Asp Asp Ile Leu Arg Val Glu Lys Tyr Leu Arg Arg Arg Lys Tyr 
            580                 585                 590


Ser Leu Phe Ala Ala Phe Tyr Ser Ala Thr Met Leu Gln Asp Val Asp 
        595                 600                 605


Asp Ala Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly Asn Lys Phe 
    610                 615                 620


Asp Met Thr Cys Leu Pro Leu Ala Ser Thr Thr Gln Tyr Ser Arg Ala 
625                 630                 635                 640


Val Phe Asp Gly Cys His Tyr Tyr Tyr Leu Pro Trp Gly Asn Val Lys 
                645                 650                 655


Pro Val Val Val Leu Ser Ser Tyr Trp Glu Asp Ile Ser His Arg Ile 
            660                 665                 670


Glu Thr Gln Asn Gln Leu Leu Gly Ile Ala Asp Arg Leu Glu Ala Gly 
        675                 680                 685


Leu Glu Gln Val His Leu Ala Leu Lys Ala Gln Cys Ser Thr Glu Asp 
    690                 695                 700


Val Asp Ser Leu Val Ala Gln Leu Thr Asp Glu Leu Ile Ala Gly Cys 
705                 710                 715                 720


Ser Gln Pro Leu Gly Asp Ile His Glu Thr Pro Ser Ala Thr His Leu 
                725                 730                 735


Asp Gln Tyr Leu Tyr Gln Leu Arg Thr His His Leu Ser Gln Ile Thr 
            740                 745                 750


Glu Ala Ala Leu Ala Leu Lys Leu Gly His Ser Glu Leu Pro Ala Ala 
        755                 760                 765


Leu Glu Gln Ala Glu Asp Trp Leu Leu Arg Leu Arg Ala Leu Ala Glu 
    770                 775                 780


Glu Pro Gln Asn Ser Leu Pro Asp Ile Val Ile Trp Met Leu Gln Gly 
785                 790                 795                 800


Asp Lys Arg Val Ala Tyr Gln Arg Val Pro Ala His Gln Val Leu Phe 
                805                 810                 815


Ser Arg Arg Gly Ala Asn Tyr Cys Gly Lys Asn Cys Gly Lys Leu Gln 
            820                 825                 830


Thr Ile Phe Leu Lys Tyr Pro Met Glu Lys Val Pro Gly Ala Arg Met 
        835                 840                 845


Pro Val Gln Ile Arg Val Lys Leu Trp Phe Gly Leu Ser Val Asp Glu 
    850                 855                 860


Lys Glu Phe Asn Gln Phe Ala Glu Gly Lys Leu Ser Val Phe Ala Glu 
865                 870                 875                 880


Thr Tyr Glu Asn Glu Thr Lys Leu Ala Leu Val Gly Asn Trp Gly Thr 
                885                 890                 895


Thr Gly Leu Thr Tyr Pro Lys Phe Ser Asp Val Thr Gly Lys Ile Lys 
            900                 905                 910


Leu Pro Lys Asp Ser Phe Arg Pro Ser Ala Gly Trp Thr Trp Ala Gly 
        915                 920                 925


Asp Trp Phe Val Cys Pro Glu Lys Thr Leu Leu His Asp Met Asp Ala 
    930                 935                 940


Gly His Leu Ser Phe Val Glu Glu Val Phe Glu Asn Gln Thr Arg Leu 
945                 950                 955                 960


Pro Gly Gly Gln Trp Ile Tyr Met Ser Asp Asn Tyr Thr Asp Val Asn 
                965                 970                 975


Gly Glu Lys Val Leu Pro Lys Asp Asp Ile Glu Cys Pro Leu Gly Trp 
            980                 985                 990


Lys Trp Glu Asp Glu Glu Trp Ser Thr Asp Leu Asn Arg Ala Val Asp 
        995                 1000                1005


Glu Gln Gly Trp Glu Tyr Ser Ile Thr Ile Pro Pro Glu Arg Lys Pro 
    1010                1015                1020


Lys His Trp Val Pro Ala Glu Lys Met Tyr Tyr Thr His Arg Arg Arg 
1025                1030                1035                1040


Arg Trp Val Arg Leu Arg Arg Arg Asp Leu Ser Gln Met Glu Ala Leu 
                1045                1050                1055


Lys Arg His Arg Gln Ala Glu Ala Glu Gly Glu Gly Trp Glu Tyr Ala 
            1060                1065                1070


Ser Leu Phe Gly Trp Lys Phe His Leu Glu Tyr Arg Lys Thr Asp Ala 
        1075                1080                1085


Phe Arg Arg Arg Arg Trp Arg Arg Arg Met Glu Pro Leu Glu Lys Thr 
    1090                1095                1100


Gly Pro Ala Ala Val Phe Ala Leu Glu Gly Ala Leu Gly Gly Val Met 
1105                1110                1115                1120


Asp Asp Lys Ser Glu Asp Ser Met Ser Val Ser Thr Leu Ser Phe Gly 
                1125                1130                1135


Val Asn Arg Pro Thr Ile Ser Cys Ile Phe Asp Tyr Gly Asn Arg Tyr 
            1140                1145                1150


His Leu Arg Cys Tyr Met Tyr Gln Ala Arg Asp Leu Ala Ala Met Asp 
        1155                1160                1165


Lys Asp Ser Phe Ser Asp Pro Tyr Ala Ile Val Ser Phe Leu His Gln 
    1170                1175                1180


Ser Gln Lys Thr Val Val Val Lys Asn Thr Leu Asn Pro Thr Trp Asp 
1185                1190                1195                1200


Gln Thr Leu Ile Phe Tyr Glu Ile Glu Ile Phe Gly Glu Pro Ala Thr 
                1205                1210                1215


Val Ala Glu Gln Pro Pro Ser Ile Val Val Glu Leu Tyr Asp His Asp 
            1220                1225                1230


Thr Tyr Gly Ala Asp Glu Phe Met Gly Arg Cys Ile Cys Gln Pro Ser 
        1235                1240                1245


Leu Glu Arg Met Pro Arg Leu Ala Trp Phe Pro Leu Thr Arg Gly Ser 
    1250                1255                1260


Gln Pro Ser Gly Glu Leu Leu Ala Ser Phe Glu Leu Ile Gln Arg Glu 
1265                1270                1275                1280


Lys Pro Ala Ile His His Ile Pro Gly Phe Glu Val Gln Glu Thr Ser 
                1285                1290                1295


Arg Ile Leu Asp Glu Ser Glu Asp Thr Asp Leu Pro Tyr Pro Pro Pro 
            1300                1305                1310


Gln Arg Glu Ala Asn Ile Tyr Met Val Pro Gln Asn Ile Lys Pro Ala 
        1315                1320                1325


Leu Gln Arg Thr Ala Ile Glu Ile Leu Ala Trp Gly Leu Arg Asn Met 
    1330                1335                1340


Lys Ser Tyr Gln Leu Ala Asn Ile Ser Ser Pro Ser Leu Val Val Glu 
1345                1350                1355                1360


Cys Gly Gly Gln Thr Val Gln Ser Cys Val Ile Arg Asn Leu Arg Lys 
                1365                1370                1375


Asn Pro Asn Phe Asp Ile Cys Thr Leu Phe Met Glu Val Met Leu Pro 
            1380                1385                1390


Arg Glu Glu Leu Tyr Cys Pro Pro Ile Thr Val Lys Val Ile Asp Asn 
        1395                1400                1405


Arg Gln Phe Gly Arg Arg Pro Val Val Gly Gln Cys Thr Ile Arg Ser 
    1410                1415                1420


Leu Glu Ser Phe Leu Cys Asp Pro Tyr Ser Ala Glu Ser Pro Ser Pro 
1425                1430                1435                1440


Gln Gly Gly Pro Asp Asp Val Ser Leu Leu Ser Pro Gly Glu Asp Val 
                1445                1450                1455


Leu Ile Asp Ile Asp Asp Lys Glu Pro Leu Ile Pro Ile Gln Glu Glu 
            1460                1465                1470


Glu Phe Ile Asp Trp Trp Ser Lys Phe Phe Ala Ser Ile Gly Glu Arg 
        1475                1480                1485


Glu Lys Cys Gly Ser Tyr Leu Glu Lys Asp Phe Asp Thr Leu Lys Val 
    1490                1495                1500


Tyr Asp Thr Gln Leu Glu Asn Val Glu Ala Phe Glu Gly Leu Ser Asp 
1505                1510                1515                1520


Phe Cys Asn Thr Phe Lys Leu Tyr Arg Gly Lys Thr Gln Glu Glu Thr 
                1525                1530                1535


Glu Asp Pro Ser Val Ile Gly Glu Phe Lys Gly Leu Phe Lys Ile Tyr 
            1540                1545                1550


Pro Leu Pro Glu Asp Pro Ala Ile Pro Met Pro Pro Arg Gln Phe His 
        1555                1560                1565


Gln Leu Ala Ala Gln Gly Pro Gln Glu Cys Leu Val Arg Ile Tyr Ile 
    1570                1575                1580


Val Arg Ala Phe Gly Leu Gln Pro Lys Asp Pro Asn Gly Lys Cys Asp 
1585                1590                1595                1600


Pro Tyr Ile Lys Ile Ser Ile Gly Lys Lys Ser Val Ser Asp Gln Asp 
                1605                1610                1615


Asn Tyr Ile Pro Cys Thr Leu Glu Pro Val Phe Gly Lys Met Phe Glu 
            1620                1625                1630


Leu Thr Cys Thr Leu Pro Leu Glu Lys Asp Leu Lys Ile Thr Leu Tyr 
        1635                1640                1645


Asp Tyr Asp Leu Leu Ser Lys Asp Glu Lys Ile Gly Glu Thr Val Val 
    1650                1655                1660


Asp Leu Glu Asn Arg Leu Leu Ser Lys Phe Gly Ala Arg Cys Gly Leu 
1665                1670                1675                1680


Pro Gln Thr Tyr Cys Val Ser Gly Pro Asn Gln Trp Arg Asp Gln Leu 
                1685                1690                1695


Arg Pro Ser Gln Leu Leu His Leu Phe Cys Gln Gln His Arg Val Lys 
            1700                1705                1710


Ala Pro Val Tyr Arg Thr Asp Arg Val Met Phe Gln Asp Lys Glu Tyr 
        1715                1720                1725


Ser Ile Glu Glu Ile Glu Ala Gly Arg Ile Pro Asn Pro His Leu Gly 
    1730                1735                1740


Pro Val Glu Glu Arg Leu Ala Leu His Val Leu Gln Gln Gln Gly Leu 
1745                1750                1755                1760


Val Pro Glu His Val Glu Ser Arg Pro Leu Tyr Ser Pro Leu Gln Pro 
                1765                1770                1775


Asp Ile Glu Gln Gly Lys Leu Gln Met Trp Val Asp Leu Phe Pro Lys 
            1780                1785                1790


Ala Leu Gly Arg Pro Gly Pro Pro Phe Asn Ile Thr Pro Arg Arg Ala 
        1795                1800                1805


Arg Arg Phe Phe Leu Arg Cys Ile Ile Trp Asn Thr Arg Asp Val Ile 
    1810                1815                1820


Leu Asp Asp Leu Ser Leu Thr Gly Glu Lys Met Ser Asp Ile Tyr Val 
1825                1830                1835                1840


Lys Gly Trp Met Ile Gly Phe Glu Glu His Lys Gln Lys Thr Asp Val 
                1845                1850                1855


His Tyr Arg Ser Leu Gly Gly Glu Gly Asn Phe Asn Trp Arg Phe Ile 
            1860                1865                1870


Phe Pro Phe Asp Tyr Leu Pro Ala Glu Gln Val Cys Thr Ile Ala Lys 
        1875                1880                1885


Lys Asp Ala Phe Trp Arg Leu Asp Lys Thr Glu Ser Lys Ile Pro Ala 
    1890                1895                1900


Arg Val Val Phe Gln Ile Trp Asp Asn Asp Lys Phe Ser Phe Asp Asp 
1905                1910                1915                1920


Phe Leu Gly Ser Leu Gln Leu Asp Leu Asn Arg Met Pro Lys Pro Ala 
                1925                1930                1935


Lys Thr Ala Lys Lys Cys Ser Leu Asp Gln Leu Asp Asp Ala Phe His 
            1940                1945                1950


Pro Glu Trp Phe Val Ser Leu Phe Glu Gln Lys Thr Val Lys Gly Trp 
        1955                1960                1965


Trp Pro Cys Val Ala Glu Glu Gly Glu Lys Lys Ile Leu Ala Gly Lys 
    1970                1975                1980


Leu Glu Met Thr Leu Glu Ile Val Ala Glu Ser Glu His Glu Glu Arg 
1985                1990                1995                2000


Pro Ala Gly Gln Gly Arg Asp Glu Pro Asn Met Asn Pro Lys Leu Glu 
                2005                2010                2015


Asp Pro Arg Arg Pro Asp Thr Ser Phe Leu Trp Phe Thr Ser Pro Tyr 
            2020                2025                2030


Lys Thr Met Lys Phe Ile Leu Trp Arg Arg Phe Arg Trp Ala Ile Ile 
        2035                2040                2045


Leu Phe Ile Ile Leu Phe Ile Leu Leu Leu Phe Leu Ala Ile Phe Ile 
    2050                2055                2060


Tyr Ala Phe Pro Asn Tyr Ala Ala Met Lys Leu Val Lys Pro Phe Ser 
2065                2070                2075                2080


<210>  165
<211>  1793
<212>  DNA
<213>  Homo sapiens

<400>  165
ggcgccggga ctccctcctg gccgcccaca gcctgtgcgc attcctgcat tcctgccgcc     60

gcccgggacc cgagcccccg gaggtgtcca ggcgcggtgc caggcgggta ctgtgcaggt    120

tcattctgcc acccatctgc attaagacac aaggtgctga ccgcagagac ctgccatgaa    180

accacacttg aagcaatgga gacaacgaat gcttttcgga atattcgctt gggggctcct    240

ctttttgctg attttcatct acttcaccga cagcaacccc gctgagcctg tacccagctc    300

cctctccttc ctggagacca ggaggctcct gccggtgcag gggaagcagc gggccatcat    360

gggcgccgca catgagccct ccccgcctgg gggcctggac gcacgccagg cgctgccccg    420

cgcccaccca gccggttcct ttcatgcggg gcctggagac ctgcagaaat gggcccagtc    480

ccaagatggg tttgaacata aagagttttt ttcatcccag gtggggagaa aatctcaaag    540

tgctttctac ccggaggatg acgactactt ttttgctgct ggtcagccag ggtggcacag    600

ccacactcag gggacattgg gattcccttc ccccggggag ccaggcccac gggagggggc    660

ttttccggct gcacaggtcc agaggaggcg ggtgaagaag aggcaccgga ggcagagaag    720

gagccacgtg ttggaggagg gcgacgacgg cgacaggctg tactcctcca tgtccagggc    780

cttcctgtac cggctctgga aggggaacgt ctcttccaaa atgctgaacc cgcgcctgca    840

gaaggcgatg aaggattacc tgaccgccaa caagcacggg gtgcgcttcc gcgggaagcg    900

ggaggccggg ctgagcaggg cacagctgct gtgccagctg cggagccgcg cgcgcgtgcg    960

gacgctggac ggcaccgagg cgcccttttc tgcgctgggc tggcggcgcc tggtgcccgc   1020

cgtgcccctg agccagctgc acccccgcgg cctgcgcagc tgcgctgtcg tcatgtctgc   1080

aggcgcaatc ctcaactctt ccttgggcga ggaaatagat tctcatgatg cggttttgag   1140

atttaactct gctcctacac gtggttatga gaaagatgtt gggaataaaa ccaccatacg   1200

catcattaat tcgcagattc tgaccaaccc cagccatcac ttcattgaca gttcactgta   1260

taaagacgtc attttggtgg cctgggaccc tgccccatat tccgcaaatc ttaacctgtg   1320

gtacaaaaaa ccggattaca acctgttcac tccatatatt cagcatcgtc agagaaaccc   1380

aaatcagcca ttttacattc ttcatcctaa atttatatgg cagctctggg atattatcca   1440

ggagaacact aaagagaaga ttcaaccaaa cccaccatct tctggtttca ttggaatcct   1500

catcatgatg tccatgtgca gagaggtgca cgtgtatgaa tatatcccat ccgtgcggca   1560

gacggagctg tgccactacc acgagctgta ctacgacgca gcctgcaccc tcggggcgta   1620

ccacccacta ctctatgaga agctcctggt gcagcgcctg aacatgggca cgcaggggga   1680

tttgcatcgc aagggcaagg tggttcttcc tggcttccag gcggtgcact gccctgcacc   1740

aagtccagtc attccacact cttaaaaagg gtttcttggg aatcaatgtg caa          1793


<210>  166
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  166

Met Lys Pro His Leu Lys Gln Trp Arg Gln Arg Met Leu Phe Gly Ile 
1               5                   10                  15


Phe Ala Trp Gly Leu Leu Phe Leu Leu Ile Phe Ile Tyr Phe Thr Asp 
            20                  25                  30


Ser Asn Pro Ala Glu Pro Val Pro Ser Ser Leu Ser Phe Leu Glu Thr 
        35                  40                  45


Arg Arg Leu Leu Pro Val Gln Gly Lys Gln Arg Ala Ile Met Gly Ala 
    50                  55                  60


Ala His Glu Pro Ser Pro Pro Gly Gly Leu Asp Ala Arg Gln Ala Leu 
65                  70                  75                  80


Pro Arg Ala His Pro Ala Gly Ser Phe His Ala Gly Pro Gly Asp Leu 
                85                  90                  95


Gln Lys Trp Ala Gln Ser Gln Asp Gly Phe Glu His Lys Glu Phe Phe 
            100                 105                 110


Ser Ser Gln Val Gly Arg Lys Ser Gln Ser Ala Phe Tyr Pro Glu Asp 
        115                 120                 125


Asp Asp Tyr Phe Phe Ala Ala Gly Gln Pro Gly Trp His Ser His Thr 
    130                 135                 140


Gln Gly Thr Leu Gly Phe Pro Ser Pro Gly Glu Pro Gly Pro Arg Glu 
145                 150                 155                 160


Gly Ala Phe Pro Ala Ala Gln Val Gln Arg Arg Arg Val Lys Lys Arg 
                165                 170                 175


His Arg Arg Gln Arg Arg Ser His Val Leu Glu Glu Gly Asp Asp Gly 
            180                 185                 190


Asp Arg Leu Tyr Ser Ser Met Ser Arg Ala Phe Leu Tyr Arg Leu Trp 
        195                 200                 205


Lys Gly Asn Val Ser Ser Lys Met Leu Asn Pro Arg Leu Gln Lys Ala 
    210                 215                 220


Met Lys Asp Tyr Leu Thr Ala Asn Lys His Gly Val Arg Phe Arg Gly 
225                 230                 235                 240


Lys Arg Glu Ala Gly Leu Ser Arg Ala Gln Leu Leu Cys Gln Leu Arg 
                245                 250                 255


Ser Arg Ala Arg Val Arg Thr Leu Asp Gly Thr Glu Ala Pro Phe Ser 
            260                 265                 270


Ala Leu Gly Trp Arg Arg Leu Val Pro Ala Val Pro Leu Ser Gln Leu 
        275                 280                 285


His Pro Arg Gly Leu Arg Ser Cys Ala Val Val Met Ser Ala Gly Ala 
    290                 295                 300


Ile Leu Asn Ser Ser Leu Gly Glu Glu Ile Asp Ser His Asp Ala Val 
305                 310                 315                 320


Leu Arg Phe Asn Ser Ala Pro Thr Arg Gly Tyr Glu Lys Asp Val Gly 
                325                 330                 335


Asn Lys Thr Thr Ile Arg Ile Ile Asn Ser Gln Ile Leu Thr Asn Pro 
            340                 345                 350


Ser His His Phe Ile Asp Ser Ser Leu Tyr Lys Asp Val Ile Leu Val 
        355                 360                 365


Ala Trp Asp Pro Ala Pro Tyr Ser Ala Asn Leu Asn Leu Trp Tyr Lys 
    370                 375                 380


Lys Pro Asp Tyr Asn Leu Phe Thr Pro Tyr Ile Gln His Arg Gln Arg 
385                 390                 395                 400


Asn Pro Asn Gln Pro Phe Tyr Ile Leu His Pro Lys Phe Ile Trp Gln 
                405                 410                 415


Leu Trp Asp Ile Ile Gln Glu Asn Thr Lys Glu Lys Ile Gln Pro Asn 
            420                 425                 430


Pro Pro Ser Ser Gly Phe Ile Gly Ile Leu Ile Met Met Ser Met Cys 
        435                 440                 445


Arg Glu Val His Val Tyr Glu Tyr Ile Pro Ser Val Arg Gln Thr Glu 
    450                 455                 460


Leu Cys His Tyr His Glu Leu Tyr Tyr Asp Ala Ala Cys Thr Leu Gly 
465                 470                 475                 480


Ala Tyr His Pro Leu Leu Tyr Glu Lys Leu Leu Val Gln Arg Leu Asn 
                485                 490                 495


Met Gly Thr Gln Gly Asp Leu His Arg Lys Gly Lys Val Val Leu Pro 
            500                 505                 510


Gly Phe Gln Ala Val His Cys Pro Ala Pro Ser Pro Val Ile Pro His 
        515                 520                 525


Ser 



<210>  167
<211>  759
<212>  DNA
<213>  Homo sapiens

<400>  167
atggggtttt tcaagtgtgc agaaagttct ctaaatacaa aatgtgcttc cagcccacca     60

aagacccccc tcacccaagc aggcagtcct cggcgaggag ggtcagcatg cccctttatg    120

ccttcttccc acgccgcgcc tcgaagcgca cgacaccgtg gtgctcggtg ctccccctgg    180

cagcgcggca ctggagtcca aggcgtgcgt gtcacatttt attccccggc agccgctcgg    240

gtgcgcgcgc tacgcgctcc cacactcacg ctggcgcccg ctagagctgg gaccctggcc    300

ggggtccccg actcacgccg cggaacttgg gggctgcaga aggcgagtgc gcggcgggag    360

tcgtcctgcc gcaggctcga gtcctcctcc tgccaccgtg gggtctcgga gctgccccgc    420

gctcccgtcc caggcggcct gcgggatcac ctctccgggg ccagcgctgc tccgcgccgg    480

cggcagctgc aagcgcgggc ggcggggcac agcgggtggc tcggcctcaa agccggcggg    540

aggctacgct cagccccgcg ctgcacgcct cattgtttcg ggcagcgcgg cggcggctcc    600

cgcggccaga ggaaccgcgg ccccgagccc cggggagagg cggcggttcc cggcccacgc    660

accgaggctg cgccgcgccc cgcccccgag ctccgctcgc cccagagccc cctccctctc    720

cgcgatccct ttcatccttc ccgctccagg ctcacctag                           759


<210>  168
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  168

Met Gly Phe Phe Lys Cys Ala Glu Ser Ser Leu Asn Thr Lys Cys Ala 
1               5                   10                  15


Ser Ser Pro Pro Lys Thr Pro Leu Thr Gln Ala Gly Ser Pro Arg Arg 
            20                  25                  30


Gly Gly Ser Ala Cys Pro Phe Met Pro Ser Ser His Ala Ala Pro Arg 
        35                  40                  45


Ser Ala Arg His Arg Gly Ala Arg Cys Ser Pro Trp Gln Arg Gly Thr 
    50                  55                  60


Gly Val Gln Gly Val Arg Val Thr Phe Tyr Ser Pro Ala Ala Ala Arg 
65                  70                  75                  80


Val Arg Ala Leu Arg Ala Pro Thr Leu Thr Leu Ala Pro Ala Arg Ala 
                85                  90                  95


Gly Thr Leu Ala Gly Val Pro Asp Ser Arg Arg Gly Thr Trp Gly Leu 
            100                 105                 110


Gln Lys Ala Ser Ala Arg Arg Glu Ser Ser Cys Arg Arg Leu Glu Ser 
        115                 120                 125


Ser Ser Cys His Arg Gly Val Ser Glu Leu Pro Arg Ala Pro Val Pro 
    130                 135                 140


Gly Gly Leu Arg Asp His Leu Ser Gly Ala Ser Ala Ala Pro Arg Arg 
145                 150                 155                 160


Arg Gln Leu Gln Ala Arg Ala Ala Gly His Ser Gly Trp Leu Gly Leu 
                165                 170                 175


Lys Ala Gly Gly Arg Leu Arg Ser Ala Pro Arg Cys Thr Pro His Cys 
            180                 185                 190


Phe Gly Gln Arg Gly Gly Gly Ser Arg Gly Gln Arg Asn Arg Gly Pro 
        195                 200                 205


Glu Pro Arg Gly Glu Ala Ala Val Pro Gly Pro Arg Thr Glu Ala Ala 
    210                 215                 220


Pro Arg Pro Ala Pro Glu Leu Arg Ser Pro Gln Ser Pro Leu Pro Leu 
225                 230                 235                 240


Arg Asp Pro Phe His Pro Ser Arg Ser Arg Leu Thr 
                245                 250


<210>  169
<211>  5284
<212>  DNA
<213>  Homo sapiens

<400>  169
gattccagct ctcgcgcccg acgaggtgga tttggctgtc caccgagctc cggcgcctgt     60

cgttctaatt gggtttggat ttgcaccgtt aaggaggggg gaagagaagg aagaggcggg    120

cgaggaaggc gagtccagct agcggctgtt gcggggaccg tagccccagc tgcagctccg    180

aagaatcccc cgccacggtt tcggtggagc gtctgggcac gggatggagt gaaagagcga    240

gtgcctctcc aagcgggggt gggagggggt caggctgtgc agaggagaga gacagcgaga    300

agaagccgcg gctggctact gcgaatttgg gattcgattg ggagggaccg ctcactcggg    360

ggaaatggat tctttaccac ggctgaccag cgttttgact ttgctgttct ctggcttgtg    420

gcatttagga ttaacagcga caaactacaa ctgtgatgat ccactagcat ccctgctctc    480

tccaatggct ttttccagtt cctcagacct cactggcact cacagcccag ctcaactcaa    540

ctggagagtt ggaactggcg gttggtcccc agcagattcc aatgctcaac agtggctcca    600

gatggacctg ggaaacagag tagagattac agcagtggcc acgcagggaa gatacggaag    660

ctctgactgg gtgacgagtt acagcctgat gttcagtgac acaggacgca actggaaaca    720

gtacaaacaa gaagacagca tctggacctt tgcaggaaac atgaatgctg acagcgtggt    780

gcaccacaag ctattgcact cagtgagagc ccgatttgtt cgctttgtgc ccctggaatg    840

gaatcccagt gggaagattg gcatgagagt cgaggtctac ggatgttcct ataaatcaga    900

tgttgctgac tttgatggcc gaagctcact tctgtacagg ttcaatcaga agttgatgag    960

tactctcaaa gatgtgatct ccctgaagtt caagagcatg caaggagatg gggtcctgtt   1020

ccatggagaa ggtcagcgtg gagaccacat caccttggaa ctccagaagg ggaggctcgc   1080

cctacacctc aatttgggtg acagcaaagc gcggctcagc agcagcttgc cctctgccac   1140

cctgggcagc ctcctggatg accagcactg gcactcggtc ctcattgagc gggtgggcaa   1200

gcaggtgaac ttcacggtgg acaagcacac acagcacttc cgcaccaagg gcgagacgga   1260

tgccttagac attgactatg agcttagttt tggaggaatt ccagtaccag gaaaacctgg   1320

gaccttttta aagaaaaact tccatggatg catcgaaaac ctttactaca atggagtaaa   1380

cataattgac ctggctaaga gacgaaagca tcagatctat actggcaatg tcactttttc   1440

ctgctccgaa ccacagattg tgcccatcac atttgtcaac tccagcggca gctatttgct   1500

gctgcccggc accccccaaa ttgatgggct ctcagtgagt ttccagtttc gaacatggaa   1560

caaggatggt ctgcttctgt ccacagagct gtctgagggc tcgggaaccc tgctgctgag   1620

cctggagggt ggaatcctga gactcgtgat tcagaaaatg acagaacgcg tagctgaaat   1680

cctcacaggc agcaacttga atgatggcct gtggcactcg gttagcatca acgccaggag   1740

gaaccgcatc acgctcactc tggatgatga agcagcaccc ccggctccag acagcacttg   1800

ggtgcagatt tattctggaa atagctacta ttttggaggg tgccccgaca atctcaccga   1860

ttcccaatgt ttaaatccca ttaaggcttt ccaaggctgc atgaggctca tctttattga   1920

taaccagccc aaggacctca tttcagttca gcaaggttcc ctggggaatt ttagtgattt   1980

acacattgat ctgtgtagca tcaaagacag gtgtttgcca aactactgtg aacatggagg   2040

aagctgctcc cagtcctgga ctaccttcta ttgtaactgc agtgacacaa gttacactgg   2100

tgccacctgc cacaactcca tctacgagca atcctgcgag gtgtacaggc accaggggaa   2160

tacagccggc ttcttctaca tcgactcaga tggcagcggc ccactgggac ctctccaggt   2220

gtactgcaat atcactgagg acaagatctg gacatcagtg cagcacaaca atacagagct   2280

gacccgagtg cggggcgcta accctgagaa gccctatgcc atggccttgg actacggggg   2340

cagcatggaa cagctggagg ccgtgatcga cggctctgag cactgtgagc aggaggtggc   2400

ctaccactgc aggaggtccc gcctgctcaa cacgccggat ggaacaccat ttacctggtg   2460

gattgggcgg tccaatgaaa ggcaccctta ctggggaggt tcccctcctg gggtccagca   2520

gtgtgagtgt ggcctagacg agagctgcct ggacattcag cacttttgca attgcgacgc   2580

tgacaaggat gaatggacaa atgatactgg ctttctttcc ttcaaagacc acttgcctgt   2640

cactcagata gttatcactg ataccgacag atcaaactca gaagccgctt ggagaattgg   2700

tcccttgcgt tgctatggtg accgacgctt ctggaacgcc gtctcatttt atacagaagc   2760

ctcttacctc cactttccta ccttccatgc ggaattcagt gccgatattt ccttcttttt   2820

taaaaccaca gcattatccg gagttttcct agaaaatctt ggcattaaag acttcattcg   2880

actcgaaata agctctcctt cagagatcac ctttgccatc gatgttggga atggtcctgt   2940

ggagcttgta gtccagtctc cttctcttct gaatgacaac caatggcact atgtccgggc   3000

tgagaggaac ctcaaggaga cctccctgca ggtggacaac cttccaagga gcaccaggga   3060

gacgtcggag gagggccatt ttcgactgca gctgaacagc cagttgtttg tagggggaac   3120

gtcatccaga cagaaaggct tcctaggatg cattcgctcc ttacacttga atggacagaa   3180

aatggacctg gaagagaggg caaaggtcac atctggagtc aggccaggct gccccggcca   3240

ctgcagcagc tacggcagca tctgccacaa cgggggcaag tgtgtggaga agcacaatgg   3300

ctacctgtgt gattgcacca attcacctta tgaagggccc ttttgcaaaa aagaggtttc   3360

tgctgttttt gaggctggca cgtcggttac ttacatgttt caagaaccct atcctgtgac   3420

caagaatata agcctctcat cctcagctat ttacacagat tcagctccat ccaaggaaaa   3480

cattgcactt agctttgtga caacccaggc acccagtctt ttgctcttta tcaattcttc   3540

ttctcaggac ttcgtggttg ttctgctctg caagaatgga agcttacagg ttcgctatca   3600

cctaaacaag gaagaaaccc atgtattcac cattgatgca gataactttg ctaacagaag   3660

gatgcaccac ttgaagatta accgagaggg aagagagctt accattcaga tggaccagca   3720

acttcgactc agttataact tctctccgga agtagagttc agggttataa ggtcactcac   3780

cttgggcaaa gtcacagaga atcttggttt ggattctgaa gttgctaaag caaatgccat   3840

gggttttgct ggatgcatgt cttccgtcca gtacaaccac atagcaccac tgaaggctgc   3900

cctgcgccat gccactgtcg cgcctgtgac tgtccatggg accttgacgg aatccagctg   3960

tggcttcatg gtggactcag atgtgaatgc agtgaccacg gtgcattctt catcagatcc   4020

ttttgggaag acagatgagc gggaaccact cacaaatgct gttcgaagtg attcggcagt   4080

catcggaggg gtgatagcag tggtgatatt catcatcttc tgtatcatcg gcatcatgac   4140

ccggttcctc taccagcaca agcagtcaca tcgtacgagc cagatgaagg agaaggaata   4200

tccagaaaat ttggacagtt ccttcagaaa tgaaattgac ttgcaaaaca cagtgagcga   4260

gtgtaaacgg gaatatttca tctgagaaac tgcagggttc ctactactct tttttcttgt   4320

tgttcaatta tctcctcccc ctcttctctc ctgtcttttg atttggtcat tctctttatt   4380

ttctgcttgc catgtctttt ctggaacata cttgcatcca ccacagcatc aattcccttg   4440

atccagccca agagaccagg cagccatggc cactgccttc ctctctgatg aacctatcgg   4500

gtgaaaacga ccactcaaga gactgacttc gccattcaag acaaggaaga gacacatgtg   4560

tgcactcctg catgttcagt tctgtacttc cagtttctaa aatgcactgt tcagttttcc   4620

aaccacttgg tggttcaggc ttgctttgaa cctgagctct taggcacatg acggtcattc   4680

ctgacatcct ccccagctca agtctattct taccatagaa cccagggcag ggagagaaga   4740

acctagaggc ctggtttgct ttggtggcat tgtaaaaaga gtaagagagg tttggtttgt   4800

ggtggtttgc tttctttacc ataagcaatc ccttgcctta actcatcacc ctttttcact   4860

atgaccctta gaccctgagt attttcaaat atatgattgc tgatagtagt gaccaaaact   4920

actttgttcc tttcttacca ctctctcctg gggccgacac gttgggacag cacaccatag   4980

cataaagcta ggggatgcat ggaaatagca gcttgaaact aggaggtaac aagaaagctt   5040

ctaggaagta gatgttccat atcttcaaaa tgcctcctcc aattttgtaa gaatgctagc   5100

taggtattcc tgggattatt atactgagat atatatatat acacacacac acacatatgt   5160

gtatatatgt atatatatat gtgagtatat atacacacac acacacacac acacatatat   5220

atatatacac acacgcacac atatatgttg ctgcagcata aagaaattga aataaaagtt   5280

taaa                                                                5284


<210>  170
<211>  1306
<212>  PRT
<213>  Homo sapiens

<400>  170

Met Asp Ser Leu Pro Arg Leu Thr Ser Val Leu Thr Leu Leu Phe Ser 
1               5                   10                  15


Gly Leu Trp His Leu Gly Leu Thr Ala Thr Asn Tyr Asn Cys Asp Asp 
            20                  25                  30


Pro Leu Ala Ser Leu Leu Ser Pro Met Ala Phe Ser Ser Ser Ser Asp 
        35                  40                  45


Leu Thr Gly Thr His Ser Pro Ala Gln Leu Asn Trp Arg Val Gly Thr 
    50                  55                  60


Gly Gly Trp Ser Pro Ala Asp Ser Asn Ala Gln Gln Trp Leu Gln Met 
65                  70                  75                  80


Asp Leu Gly Asn Arg Val Glu Ile Thr Ala Val Ala Thr Gln Gly Arg 
                85                  90                  95


Tyr Gly Ser Ser Asp Trp Val Thr Ser Tyr Ser Leu Met Phe Ser Asp 
            100                 105                 110


Thr Gly Arg Asn Trp Lys Gln Tyr Lys Gln Glu Asp Ser Ile Trp Thr 
        115                 120                 125


Phe Ala Gly Asn Met Asn Ala Asp Ser Val Val His His Lys Leu Leu 
    130                 135                 140


His Ser Val Arg Ala Arg Phe Val Arg Phe Val Pro Leu Glu Trp Asn 
145                 150                 155                 160


Pro Ser Gly Lys Ile Gly Met Arg Val Glu Val Tyr Gly Cys Ser Tyr 
                165                 170                 175


Lys Ser Asp Val Ala Asp Phe Asp Gly Arg Ser Ser Leu Leu Tyr Arg 
            180                 185                 190


Phe Asn Gln Lys Leu Met Ser Thr Leu Lys Asp Val Ile Ser Leu Lys 
        195                 200                 205


Phe Lys Ser Met Gln Gly Asp Gly Val Leu Phe His Gly Glu Gly Gln 
    210                 215                 220


Arg Gly Asp His Ile Thr Leu Glu Leu Gln Lys Gly Arg Leu Ala Leu 
225                 230                 235                 240


His Leu Asn Leu Gly Asp Ser Lys Ala Arg Leu Ser Ser Ser Leu Pro 
                245                 250                 255


Ser Ala Thr Leu Gly Ser Leu Leu Asp Asp Gln His Trp His Ser Val 
            260                 265                 270


Leu Ile Glu Arg Val Gly Lys Gln Val Asn Phe Thr Val Asp Lys His 
        275                 280                 285


Thr Gln His Phe Arg Thr Lys Gly Glu Thr Asp Ala Leu Asp Ile Asp 
    290                 295                 300


Tyr Glu Leu Ser Phe Gly Gly Ile Pro Val Pro Gly Lys Pro Gly Thr 
305                 310                 315                 320


Phe Leu Lys Lys Asn Phe His Gly Cys Ile Glu Asn Leu Tyr Tyr Asn 
                325                 330                 335


Gly Val Asn Ile Ile Asp Leu Ala Lys Arg Arg Lys His Gln Ile Tyr 
            340                 345                 350


Thr Gly Asn Val Thr Phe Ser Cys Ser Glu Pro Gln Ile Val Pro Ile 
        355                 360                 365


Thr Phe Val Asn Ser Ser Gly Ser Tyr Leu Leu Leu Pro Gly Thr Pro 
    370                 375                 380


Gln Ile Asp Gly Leu Ser Val Ser Phe Gln Phe Arg Thr Trp Asn Lys 
385                 390                 395                 400


Asp Gly Leu Leu Leu Ser Thr Glu Leu Ser Glu Gly Ser Gly Thr Leu 
                405                 410                 415


Leu Leu Ser Leu Glu Gly Gly Ile Leu Arg Leu Val Ile Gln Lys Met 
            420                 425                 430


Thr Glu Arg Val Ala Glu Ile Leu Thr Gly Ser Asn Leu Asn Asp Gly 
        435                 440                 445


Leu Trp His Ser Val Ser Ile Asn Ala Arg Arg Asn Arg Ile Thr Leu 
    450                 455                 460


Thr Leu Asp Asp Glu Ala Ala Pro Pro Ala Pro Asp Ser Thr Trp Val 
465                 470                 475                 480


Gln Ile Tyr Ser Gly Asn Ser Tyr Tyr Phe Gly Gly Cys Pro Asp Asn 
                485                 490                 495


Leu Thr Asp Ser Gln Cys Leu Asn Pro Ile Lys Ala Phe Gln Gly Cys 
            500                 505                 510


Met Arg Leu Ile Phe Ile Asp Asn Gln Pro Lys Asp Leu Ile Ser Val 
        515                 520                 525


Gln Gln Gly Ser Leu Gly Asn Phe Ser Asp Leu His Ile Asp Leu Cys 
    530                 535                 540


Ser Ile Lys Asp Arg Cys Leu Pro Asn Tyr Cys Glu His Gly Gly Ser 
545                 550                 555                 560


Cys Ser Gln Ser Trp Thr Thr Phe Tyr Cys Asn Cys Ser Asp Thr Ser 
                565                 570                 575


Tyr Thr Gly Ala Thr Cys His Asn Ser Ile Tyr Glu Gln Ser Cys Glu 
            580                 585                 590


Val Tyr Arg His Gln Gly Asn Thr Ala Gly Phe Phe Tyr Ile Asp Ser 
        595                 600                 605


Asp Gly Ser Gly Pro Leu Gly Pro Leu Gln Val Tyr Cys Asn Ile Thr 
    610                 615                 620


Glu Asp Lys Ile Trp Thr Ser Val Gln His Asn Asn Thr Glu Leu Thr 
625                 630                 635                 640


Arg Val Arg Gly Ala Asn Pro Glu Lys Pro Tyr Ala Met Ala Leu Asp 
                645                 650                 655


Tyr Gly Gly Ser Met Glu Gln Leu Glu Ala Val Ile Asp Gly Ser Glu 
            660                 665                 670


His Cys Glu Gln Glu Val Ala Tyr His Cys Arg Arg Ser Arg Leu Leu 
        675                 680                 685


Asn Thr Pro Asp Gly Thr Pro Phe Thr Trp Trp Ile Gly Arg Ser Asn 
    690                 695                 700


Glu Arg His Pro Tyr Trp Gly Gly Ser Pro Pro Gly Val Gln Gln Cys 
705                 710                 715                 720


Glu Cys Gly Leu Asp Glu Ser Cys Leu Asp Ile Gln His Phe Cys Asn 
                725                 730                 735


Cys Asp Ala Asp Lys Asp Glu Trp Thr Asn Asp Thr Gly Phe Leu Ser 
            740                 745                 750


Phe Lys Asp His Leu Pro Val Thr Gln Ile Val Ile Thr Asp Thr Asp 
        755                 760                 765


Arg Ser Asn Ser Glu Ala Ala Trp Arg Ile Gly Pro Leu Arg Cys Tyr 
    770                 775                 780


Gly Asp Arg Arg Phe Trp Asn Ala Val Ser Phe Tyr Thr Glu Ala Ser 
785                 790                 795                 800


Tyr Leu His Phe Pro Thr Phe His Ala Glu Phe Ser Ala Asp Ile Ser 
                805                 810                 815


Phe Phe Phe Lys Thr Thr Ala Leu Ser Gly Val Phe Leu Glu Asn Leu 
            820                 825                 830


Gly Ile Lys Asp Phe Ile Arg Leu Glu Ile Ser Ser Pro Ser Glu Ile 
        835                 840                 845


Thr Phe Ala Ile Asp Val Gly Asn Gly Pro Val Glu Leu Val Val Gln 
    850                 855                 860


Ser Pro Ser Leu Leu Asn Asp Asn Gln Trp His Tyr Val Arg Ala Glu 
865                 870                 875                 880


Arg Asn Leu Lys Glu Thr Ser Leu Gln Val Asp Asn Leu Pro Arg Ser 
                885                 890                 895


Thr Arg Glu Thr Ser Glu Glu Gly His Phe Arg Leu Gln Leu Asn Ser 
            900                 905                 910


Gln Leu Phe Val Gly Gly Thr Ser Ser Arg Gln Lys Gly Phe Leu Gly 
        915                 920                 925


Cys Ile Arg Ser Leu His Leu Asn Gly Gln Lys Met Asp Leu Glu Glu 
    930                 935                 940


Arg Ala Lys Val Thr Ser Gly Val Arg Pro Gly Cys Pro Gly His Cys 
945                 950                 955                 960


Ser Ser Tyr Gly Ser Ile Cys His Asn Gly Gly Lys Cys Val Glu Lys 
                965                 970                 975


His Asn Gly Tyr Leu Cys Asp Cys Thr Asn Ser Pro Tyr Glu Gly Pro 
            980                 985                 990


Phe Cys Lys Lys Glu Val Ser Ala Val Phe Glu Ala Gly Thr Ser Val 
        995                 1000                1005


Thr Tyr Met Phe Gln Glu Pro Tyr Pro Val Thr Lys Asn Ile Ser Leu 
    1010                1015                1020


Ser Ser Ser Ala Ile Tyr Thr Asp Ser Ala Pro Ser Lys Glu Asn Ile 
1025                1030                1035                1040


Ala Leu Ser Phe Val Thr Thr Gln Ala Pro Ser Leu Leu Leu Phe Ile 
                1045                1050                1055


Asn Ser Ser Ser Gln Asp Phe Val Val Val Leu Leu Cys Lys Asn Gly 
            1060                1065                1070


Ser Leu Gln Val Arg Tyr His Leu Asn Lys Glu Glu Thr His Val Phe 
        1075                1080                1085


Thr Ile Asp Ala Asp Asn Phe Ala Asn Arg Arg Met His His Leu Lys 
    1090                1095                1100


Ile Asn Arg Glu Gly Arg Glu Leu Thr Ile Gln Met Asp Gln Gln Leu 
1105                1110                1115                1120


Arg Leu Ser Tyr Asn Phe Ser Pro Glu Val Glu Phe Arg Val Ile Arg 
                1125                1130                1135


Ser Leu Thr Leu Gly Lys Val Thr Glu Asn Leu Gly Leu Asp Ser Glu 
            1140                1145                1150


Val Ala Lys Ala Asn Ala Met Gly Phe Ala Gly Cys Met Ser Ser Val 
        1155                1160                1165


Gln Tyr Asn His Ile Ala Pro Leu Lys Ala Ala Leu Arg His Ala Thr 
    1170                1175                1180


Val Ala Pro Val Thr Val His Gly Thr Leu Thr Glu Ser Ser Cys Gly 
1185                1190                1195                1200


Phe Met Val Asp Ser Asp Val Asn Ala Val Thr Thr Val His Ser Ser 
                1205                1210                1215


Ser Asp Pro Phe Gly Lys Thr Asp Glu Arg Glu Pro Leu Thr Asn Ala 
            1220                1225                1230


Val Arg Ser Asp Ser Ala Val Ile Gly Gly Val Ile Ala Val Val Ile 
        1235                1240                1245


Phe Ile Ile Phe Cys Ile Ile Gly Ile Met Thr Arg Phe Leu Tyr Gln 
    1250                1255                1260


His Lys Gln Ser His Arg Thr Ser Gln Met Lys Glu Lys Glu Tyr Pro 
1265                1270                1275                1280


Glu Asn Leu Asp Ser Ser Phe Arg Asn Glu Ile Asp Leu Gln Asn Thr 
                1285                1290                1295


Val Ser Glu Cys Lys Arg Glu Tyr Phe Ile 
            1300                1305


<210>  171
<211>  16557
<212>  DNA
<213>  Homo sapiens

<400>  171
aaagacagaa ccccagagaa aaacgctgcc aattcgttgc tttattgttc cctgcctggg     60

gacctcaata gccttttcca ttaaccttcc cttcttacgc aacggttaat gactttgggg    120

gttgttttgc tttctgtttc tgctgagtca ctaaattttg cctctttgtc cccaggtgct    180

gctcagcata aaagttaaaa gtgcaattca ggaagtactg ggattctgtg tagagccgag    240

gaaaccattt ccctaagaga agctctgttc cttggcttgt ccttccttcc cgggaaggaa    300

gcttccgagg aacgaaggga gaagctttgt tttgcctgca gaagcagccc tgtgctcggc    360

tgagggttct cagctggctg tgaactgcgg agcattgtag gcgcctggct ggctcaggcc    420

aatgcagaag tctctccctt ctccaaagac ccaaatcccc acagaaccag cttcgagtta    480

ctttcccttc aaggggatta aaataattgt gatttgtggc gctctccgtt cgcggtggta    540

ttttcctgtt gtgttaaatg cctcttatta agtaatagat gtgatttatg tgaacgacga    600

aggggtgtgt ggtggattcg gtgattaatc agtgaattcc catccgctgg catctctcac    660

tgcccctctt gcgtgatgta agatcagacg taccctgcat tgaaaagtca agacacacgg    720

gcgtctcgct cgcgctcaca cacgctctgc ctcctctctc ccgcacgcgc gcatccctcc    780

accttccaca tcctgctcca ggcaggagaa ggctgactgg ctggactcat tgagctgaag    840

aatttccagt gacatttgta aatgacgccg ctcgattcca ggctccaagc ggcccctgcc    900

gccgccgccg ccgccgggcc gaaggtgccg ccgagcagtc tccagcgcag gcttccttac    960

cgggcgacca caatgtccga gtttctcctc gccttactca ctctctcggg attattgccg   1020

attgccaggg tgctgaccgt gggagccgac cgagatcagc agttgtgtga tcctggtgaa   1080

tttctttgcc acgatcacgt gacttgtgtc tcccagagct ggctgtgtga tggggaccct   1140

gactgccctg atgattcaga cgagtcttta gatacctgtc ccgaggaggt agaaatcaag   1200

tgccccttga atcacattgc ttgccttggt accaacaaat gtgttcattt atcccagctg   1260

tgcaatggtg tcttggactg cccagatggg tatgacgaag gagtacattg tcaggaactg   1320

ttatccaatt gccaacagct gaattgtcag tataaatgta caatggtcag aaatagtaca   1380

agatgttact gtgaggatgg attcgaaata acagaagatg ggagaagctg taaagatcaa   1440

gatgaatgtg ctgtttatgg tacatgcagc cagacctgca gaaacacaca tggatcctac   1500

acttgcagtt gtgtggaagg ctacctaatg cagccagaca acagatcttg caaggctaaa   1560

attgaaccta cagatagacc acctatacta ttaattgcaa attttgaaac aattgaggtt   1620

ttctatctta atggaagtaa aatggcaact ctaagctcag tcaatggaaa tgaaattcat   1680

actctggatt ttatttataa tgaagatatg atttgttgga ttgaatcaag agaatcttca   1740

aatcaactca aatgtatcca gataacaaaa gcaggaggat taacagatga atggacaatc   1800

aatattcttc aatccttcca caatgtgcaa caaatggcga ttgactggct cactcgaaat   1860

ctctattttg tggaccatgt cggtgaccgg atctttgttt gtaattccaa cggttctgta   1920

tgtgtcaccc tgattgatct ggagcttcac aatcctaaag caatagcagt agatccaata   1980

gcaggaaaac ttttctttac tgactacggg aatgtcgcca aagtggagag atgtgacatg   2040

gatgggatga accgaacaag gataattgat tcaaagacag agcagccagc tgcactggca   2100

ctagacctag tcaacaaatt ggtttactgg gtagatcttt acttggacta tgtgggagta   2160

gtggactatc aaggaaaaaa tagacacact gtcattcaag gcagacaagt tagacatctt   2220

tatggtataa ctgtgtttga agattatttg tatgcaacca attctgataa ctacaatatc   2280

gtaaggataa accgatttaa tgggactgat attcactcat taattaaaat tgagaatgct   2340

tggggaatcc gaatttatca aaaaagaact caaccaacag tcagaagcca tgcatgtgaa   2400

gtcgatccat atggaatgcc agggggctgt tcacacatct gtctactcag cagcagttac   2460

aaaactcgga cttgtcgctg caggactggc ttcaacttgg gaagtgatgg caggtcatgc   2520

aaaagaccaa agaatgagtt gttcctcttt tatgggaaag gacgcccagg aattgttaga   2580

ggaatggact tgaataccaa gatagctgat gaatacatga tccccataga aaatctggta   2640

aaccctcgtg ctttagactt tcacgcagaa accaattaca tctactttgc tgacaccacc   2700

agtttcctaa ttggccggca gaagatagat ggcacagaga gagaaaccat cctgaaagat   2760

gatctggata atgtagaggg cattgctgtg gactggattg gaaataatct ttactggacc   2820

aatgatggcc ataggaaaac cattaatgtg gccaggctgg aaaaagcttc tcagagtcgg   2880

aagactcttt tagagggtga aatgtctcat cccagaggaa ttgtggtgga tccagttaat   2940

ggttggatgt attggacaga ctgggaggaa gatgaaatag atgacagcgt gggaaggatt   3000

gagaaggcct ggatggatgg attcaatcgg cagatttttg tgacttcaaa gatgctgtgg   3060

ccaaacggtt taactctgga ctttcacacc aacacattat actggtgtga tgcctattac   3120

gatcatattg aaaaagtatt tttgaatggg actcacagga agattgttta cagtgggaga   3180

gagttgaacc accctttcgg actgtcgcat catggaaatt atgtgttctg gactgattat   3240

atgaatggtt ccatttttca actagatttg ataacaagtg aggtgacatt gctgaggcat   3300

gaaagaccac ccctatttgg gcttcagatt tatgatccac gaaagcaaca aggtgacaat   3360

atgtgccgag taaataatgg gggctgtagt acactttgct tggctatccc aggaggccgg   3420

gtgtgtgctt gtgccgataa tcaacttttg gatgaaaatg ggacaacttg cacatttaat   3480

cctggagaag cactacctca catatgtaaa gctggagagt ttcgctgcaa aaacagacac   3540

tgtatccaag ctcggtggaa atgtgatggc gacgatgact gcctagacgg aagcgatgag   3600

gattcagtaa actgcttcaa tcatagctgt cctgatgatc agtttaaatg ccagaataat   3660

cgctgcatcc ccaagagatg gctttgtgat ggagctaatg actgtgggag caatgaagat   3720

gaatccaatc aaacttgcac agccagaaca tgccaggtag accagttttc ttgcggaaat   3780

gggcgttgca ttcccagagc atggctgtgt gacagggaag acgactgtgg tgaccagaca   3840

gatgaaatgg catcttgtga attcccaact tgtgagccac taacccaatt cgtatgcaaa   3900

agtggaagat gcattagcag caaatggcac tgcgactctg atgacgactg tggggacggg   3960

agtgatgagg tgggctgtgt tcactcttgc tttgataatc agttcagatg ttccagtggc   4020

agatgcatcc caggccactg ggcctgtgat ggtgacaatg actgtgggga cttcagtgat   4080

gaagcccaga tcaattgtac taaagaagag attcattctc ctgctggttg taacggaaat   4140

gaatttcagt gccaccctga tggtaattgc gttcctgatt tgtggcgctg tgatggagaa   4200

aaagactgtg aagatggtag tgatgaaaaa ggttgcaatg gtaccatacg attgtgtgac   4260

cacaaaacca agttttcctg ttggagtaca gggagatgca tcaacaaagc atgggtgtgt   4320

gatggagata ttgattgcga agatcagtca gatgaagatg actgtgacag tttcttgtgt   4380

ggaccaccca agcatccttg tgctaatgac acctcagtct gcctgcagcc agagaaactc   4440

tgcaatggga aaaaggattg tcctgatggc tctgatgaag gctatctctg tgatgagtgt   4500

tcgctgaaca atggaggctg tagcaaccac tgttctgttg ttcctggaag aggaattgtc   4560

tgttcctgcc ctgaaggact tcaactcaac aaagacaata aaacatgtga aattgtggat   4620

tattgtagca atcatctaaa gtgcagccaa gtatgtgagc agcacaagca cacagtcaag   4680

tgctcatgtt atgaaggttg gaagctggat gtagacggtg aaagttgtac aagtgttgat   4740

ccttttgaag cattcatcat cttttctatt cgtcatgaga tcagaaggat tgatcttcac   4800

aaaagagact atagtctact tgttcctgga ttgagaaaca caatagcact tgattttcac   4860

ttcaatcaaa gtttacttta ttggacagat gttgtagaag acagaatata ccggggaaag   4920

ctttctgaaa gtggaggtgt cagtgccatt gaagtggttg tggagcatgg cctggctact   4980

ccagaaggcc tgacagtcga ctggatagca ggaaacatat actggataga cagcaatctg   5040

gaccaaatcg aagtggccaa actagatggc tccctaagaa ctacactaat agcaggagcc   5100

atggaacacc ccagggccat tgctttggac ccaagatatg gaattctttt ctggacagac   5160

tgggatgcaa attttcctcg cattgaatct gcctctatga gtggtgctgg gagaaaaacc   5220

atctataaag acatgaaaac tggggcttgg cctaatggac taactgtgga ccactttgag   5280

aaaaggatag tgtggacaga cgccaggtca gatgctattt attcagccct ctatgatgga   5340

acaaacatga tagaaatcat ccgaggtcat gaataccttt cccatccctt tgctgtgtct   5400

ctatatggga gtgaagtcta ctggacagac tggaggacca acacattgtc caaagccaat   5460

aagtggacag ggcagaatgt cagtgtgatt cagaaaacca gtgcacagcc atttgacctt   5520

cagatatacc atcccagtcg ccagccacag gctcccaatc cttgtgcagc taatgatggc   5580

aaaggcccct gctctcacat gtgtctaatc aatcacaata ggagtgctgc ctgtgcgtgc   5640

ccccacttga tgaagctttc ttcagacaag aagacctgct atgaaatgaa aaaatttctt   5700

ctttatgcaa gacgttctga aatcagagga gtggatattg acaatccata ctttaacttc   5760

atcacggcat ttacagtccc tgatattgat gacgttactg tgatagactt cgatgcatct   5820

gaggaacgtt tatactggac agatattaaa acacaaacca ttaaacgagc ttttattaac   5880

ggaactgggt tagaaactgt tatttcaaga gatattcaga gtatcagagg gctagcagtg   5940

gattgggtgt cacgtaattt atactggatt agctcagaat ttgatgaaac gcaaattaat   6000

gtggcaaggc tagatggctc tttgaaaacc tcaattatcc atggaatcga taagccacag   6060

tgtcttgcag ctcacccagt caggggaaaa ctctactgga ccgatggaaa cacaattaac   6120

atggcaaata tggatggcag taatagcaag attctgtttc agaatcagaa ggagccagtt   6180

ggtctatcga tagactatgt ggaaaacaag ctttattgga tcagttcagg gaatggaacc   6240

ataaatagat gcaacctgga tggtggtaat ttagaagtaa tcgagtcaat gaaagaagaa   6300

ttaacaaaag ctacagccct aaccatcatg gataagaaac tgtggtgggc agaccaaaac   6360

ttagcccagc taggaacctg cagcaaaaga gacggaagaa accccaccat cctacggaat   6420

aagacttctg gggtagttca tatgaaagtc tatgataaag aagcacagca aggcagcaat   6480

tcctgccaac taaacaatgg tggatgctct caactttgtt taccaacatc tgaaactaca   6540

aggacttgta tgtgtacagt gggatattat ctccaaaaga accgtatgtc atgtcaaggt   6600

atagaatcat ttcttatgta ctctgttcat gaaggaatca ggggaatacc tcttgaacca   6660

agtgacaaaa tggatgcttt gatgcctata tcaggaactt catttgccgt gggaatagat   6720

ttccatgcag aaaatgatac catctactgg acagacatgg gcttcaataa aattagcaga   6780

gctaaaagag atcagacttg gaaagaagat atcattacca atggcttggg aagagtggaa   6840

gggatagctg ttgactggat tgctggtaac atatattgga cagatcatgg tttcaactta   6900

attgaagttg caagactcaa tggttctttc cgttatgtaa ttatttccca aggcctggat   6960

caaccaagat ctatagctgt gcacccagag aaaggcctct tgttctggac tgaatgggga   7020

caaatgccct gtattggaaa ggctcgcttg gatggctcag agaaggttgt ccttgtaagc   7080

atgggaatag catggccgaa tggcatctcc atcgactatg aggaaaataa attgtactgg   7140

tgtgatgctc gcacagacaa gatagagaga atcgaccttg agactggagg gaatcgcgag   7200

atggtgctgt caggaagcaa tgtggatatg ttttcagttg cagtctttgg ggcttacatc   7260

tactggtctg acagagcaca tgcaaacggg tctgtcagaa ggggccacaa gaatgatgcc   7320

acagaaacga taaccatgag aaccggcctt ggagtcaacc tgaaggaggt taaaatattt   7380

aaccgagtaa gagagaaagg gaccaatgtt tgtgccaggg acaatggtgg ctgtaagcaa   7440

ctctgtcttt atcgaggaaa ttcccggaga acttgtgctt gtgcccatgg atatttggca   7500

gaagatggag ttacttgcct gaggcatgaa ggctatttac tgtattcagg aagaacaata   7560

ttaaaaagta tacatctttc tgatgaaacc aatttaaatt ccccaataag gccatatgag   7620

aatccacgtt atttcaagaa tgtcatagcc ttggcttttg actataatca aagaagaaaa   7680

ggtaccaacc gaatctttta cagtgatgca cactttggaa atatacagct tattaaagac   7740

aactgggaag acagacaagt aattgttgaa aatgtgggtt ctgtggaagg acttgcctat   7800

cacagagcct gggatacact gtactggaca agctctacca cctcatccat caccagacac   7860

actgtggacc agactcggcc tggagcattt gacagggaag ctgtcatcac catgtcagaa   7920

gatgaccatc cacatgtgct agccttggat gaatgtcaaa atttaatgtt ttggaccaac   7980

tggaatgaac aacatccaag tatcatgaga tctactctga ctgggaaaaa tgctcaagtg   8040

gtggtcagta cagacatact cactccaaat ggacttacta tcgactaccg tgcagagaag   8100

ctgtatttct cagatggcag tctaggaaaa attgaaaggt gtgaatacga tggatcccag   8160

agacatgtga tagttaaatc tgggccaggg actttcctca gtttggctgt ttatgacaat   8220

tatatattct ggtcggactg gggaagaaga gctatactgc ggtccaacaa gtacacagga   8280

ggagatacaa aaattcttcg ttccgatatt ccacatcagc caatgggaat catagctgtt   8340

gccaatgaca ccaatagctg tgaactttct ccatgtgcat tattgaatgg aggctgccat   8400

gacttgtgcc ttttaactcc caatgggaga gtgaattgtt cctgcagagg ggaccgaata   8460

ttgctagagg acaacagatg tgtgactaaa aattcctcct gcaacgctta ttcggagttt   8520

gaatgtggaa atggtgagtg cattgactac cagctcacct gtgatggcat tcctcactgt   8580

aaagataaat cagatgaaaa actgctctac tgtgaaaaca gaagctgtcg aagaggcttc   8640

aagccatgct ataatcgccg ctgcattcct catggcaagt tatgtgatgg agaaaatgac   8700

tgcggagaca actctgatga attagattgt aaagtttcaa cctgtgccac ggttgagttc   8760

cgctgtgcag atgggacttg tattccaaga tcagcacgat gcaaccagaa catagattgt   8820

gcagatgctt cagatgaaaa gaactgcaat aacacagact gcacacattt ctataagctt   8880

ggagtgaaaa ccacagggtt cataagatgt aattctacct cactgtgtgt tctgccaacc   8940

tggatatgcg acgggtctaa tgactgtgga gactattcag atgaattaaa gtgcccagtt   9000

caaaacaaac acaaatgtga agaaaattat tttagttgtc ctagtggaag atgcattttg   9060

aatacctgga tatgcgatgg tcagaaagat tgtgaggatg gacgtgatga attccactgt   9120

gattcttctt gctcttggaa ccaatttgct tgttccgcac aaaaatgtat ttctaagcat   9180

tggatttgtg atggagaaga tgactgtggg gatgggttag atgaaagtga cagcatttgt   9240

ggtgccataa cctgtgctgc tgacatgttc agctgccagg gctctcgtgc ctgcgtgccc   9300

cgacattggc tttgtgatgg tgaaagggac tgtccagatg gaagcgatga gctttccaca   9360

gcaggctgcg ctcccaataa tacatgtgat gaaaatgctt tcatgtgcca taataaagta   9420

tgcattccca agcaatttgt ttgtgaccat gatgacgact gtggagatgg ctctgatgag   9480

tcaccgcagt gtggatatcg acagtgtggt acagaagaat ttagttgtgc tgatgggcgg   9540

tgtcttctaa atactcaatg gcagtgtgat ggagactttg actgtcctga ccattctgat   9600

gaagcacctt taaacccaaa gtgtaaaagt gcagaacagt catgcaacag ttcatttttt   9660

atgtgcaaaa atggcaggtg cattcccagt ggaggtcttt gcgacaataa ggatgactgt   9720

ggcgatggtt cagatgagag aaactgccat ataaatgaat gtttgagtaa gaaagtcagt   9780

ggatgttctc aagactgtca agaccttccg gtcagttata agtgcaaatg ctggcctgga   9840

ttccaactga aggatgacgg caaaacatgt gtagacattg atgaatgctc ttcaggcttt   9900

ccctgtagcc agcaatgcat caatacatac gggacttaca agtgcctctg tacagatggg   9960

tatgaaatac aacctgataa cccaaatggc tgcaaatcgc tctcagatga agaacctttt  10020

ttaattcttg ctgatcatca tgagataagg aaaattagca ctgatggctc caactacaca  10080

cttttaaaac agggattaaa caatgttatt gctatagact ttgattacag agaagaattc  10140

atctattgga tcgattctag ccgacccaat ggcagtcgca taaatagaat gtgtttaaat  10200

ggaagtgaca ttaaggtagt tcataacaca gcggtcccca atgcacttgc tgtcgattgg  10260

attggaaaaa acctctattg gtctgacaca gaaaaaagaa tcattgaagt atccaaactc  10320

aatggcttgt accctactat actcgttagc aaaaggctga agtttcccag agacttgtct  10380

ttagatcctc aagctggata tttgtattgg attgactgct gcgagtatcc tcatattggc  10440

cgtgttggaa tggatggaac caatcagagt gttgtcatag aaaccaagat ttctagacct  10500

atggcactaa caatagatta tgttaatcgt agactctact gggccgatga aaatcacatt  10560

gaatttagca acatggatgg atctcataga cacaaagtcc ctaatcaaga tattccaggg  10620

gtgattgcac taacattgtt tgaagactac atctactgga ctgatgggaa aaccaagtca  10680

ctcagccgtg cccataaaac atcgggagca gacagactct cactgattta ctcatggcat  10740

gccatcacag atatccaggt gtatcattct tatagacaac ctgatgtctc caaacatctc  10800

tgcatgataa ataatggtgg ttgcagtcat ttgtgccttt tagcccctgg aaaaacccac  10860

acttgtgcat gtcccactaa cttctatctg gcagctgata ataggacttg cttatccaac  10920

tgcacagcca gccagtttcg ttgcaaaact gacaaatgta ttccattctg gtggaaatgt  10980

gacaccgtgg atgactgtgg tgatggatct gatgaacctg atgactgtcc tgaatttaga  11040

tgtcagccag gccgatttca gtgtgggact ggactctgtg ctctaccagc tttcatctgt  11100

gatggagaga atgattgtgg agacaattct gatgaactca actgtgacac acatgtctgc  11160

ctgtcaggtc aattcaaatg taccaagaac cagaaatgta tcccagtaaa cttaagatgt  11220

aatgggcaag atgactgtgg tgatgaggaa gatgaaagag actgtcctga aaacagctgt  11280

tctccagact atttccagtg taagactacg aagcattgca tttccaagct gtgggtttgt  11340

gacgaggatc cagactgtgc agatgcatca gacgaggcca actgcgataa aaagacttgt  11400

ggacctcatg aattccagtg taaaaacaac aactgtattc ccgatcactg gcggtgtgat  11460

agccaaaatg actgcagtga taattcagat gaagaaaact gtaagccaca gacatgtaca  11520

ttgaaagatt tcctctgtgc caatggggac tgtgtttctt caaggttttg gtgtgatgga  11580

gattttgact gtgcagatgg ctctgatgag agaaattgtg agacaagttg ttccaaagat  11640

cagttccggt gttccaatgg tcagtgtata ccagcaaaat ggaaatgtga tggccatgaa  11700

gactgcaaat atggggaaga tgagaaaagc tgtgagccag cttctcctac ttgctcatca  11760

cgtgaatata tatgtgccag tgatggatgt atttcagcat ctttgaaatg taatggagaa  11820

tatgattgtg ctgatggttc agatgagatg gactgtgtga ctgaatgtaa ggaagatcag  11880

tttcggtgca aaaataaagc ccactgtatt ccaattagat ggctgtgtga tggaattcat  11940

gactgtgtgg atggcagtga tgaagagaac tgtgaaagag gaggaaatat atgtagagct  12000

gatgagttcc tttgcaataa ttctctctgc aaactacatt tctgggtgtg tgatggagag  12060

gacgactgtg gagacaactc tgatgaagcc cctgatatgt gtgtcaaatt tctttgtcca  12120

tccacgagac ctcacagatg cagaaataac agaatatgcc tacagtcgga gcaaatgtgc  12180

aatgggattg atgaatgcgg tgacaattca gatgaagatc actgtggtgg taagctgaca  12240

tataaagcaa ggccttgtaa aaaggatgag tttgcttgta gtaataaaaa atgcatccct  12300

atggatctcc agtgtgatcg acttgatgac tgcggagatg gttcagatga gcaaggatgc  12360

agaatagctc ctactgaata tacctgtgaa gataatgtga atccatgtgg agatgatgca  12420

tattgtaatc aaataaaaac atctgttttc tgtcgctgta agcctggatt tcagagaaac  12480

atgaaaaaca gacaatgtga agaccttaat gaatgtttgg tgtttggcac atgttcccat  12540

caatgtataa atgtggaagg atcatataaa tgtgtgtgtg accagaattt tcaagaaaga  12600

aataacacct gcatagcaga aggctctgaa gatcaagttc tctacattgc taatgacact  12660

gatatcctgg gttttatata tccattcaac tacagtggcg atcatcaaca aatttctcat  12720

attgaacata attcaagaat aacagggatg gatgtatatt atcaaagaga tatgattatt  12780

tggagtactc agtttaatcc aggcggaatt ttctacaaaa ggatccatgg cagagaaaaa  12840

aggcaagcaa acagtggctt gatttgtcct gaatttaaaa ggcccaggga cattgcagtt  12900

gactgggtgg ctggaaacat ttactggact gatcattcta gaatgcattg gttcagttac  12960

tacactactc actggaccag tctgaggtac tctatcaacg tagggcagct gaatggcccc  13020

aactgcacca gactcttaac aaatatggct ggagaaccct atgctattgc agtaaatcct  13080

aaaagaggga tgatgtactg gactgttgtt ggggatcatt cccatataga agaagcagcc  13140

atggatggta cactgagaag gattttagta caaaagaact tacagagacc cacaggtttg  13200

gctgtggatt attttagtga acgcatatat tgggctgact ttgagctctc catcattggc  13260

agtgttctgt atgatggctc taattcagta gtctctgtca gcagcaaaca aggtttatta  13320

catccacata ggatcgatat ctttgaagat tatatatatg gagcaggacc taaaaatggt  13380

gtatttcgag ttcaaaaatt tggccatggt tcagtagagt acttagcttt aaatattgat  13440

aaaacaaaag gtgttttgat atctcatcgt tataaacaac tagatttacc caatccatgc  13500

ttggatttag catgcgaatt tctttgcttg ctaaatcctt ctggggccac ttgtgtgtgt  13560

ccagaaggaa aatatttgat taatggcacc tgcaatgatg acagcctgtt agatgattca  13620

tgtaagttaa cttgtgaaaa tggaggaaga tgcattttaa atgagaaagg tgatttgagg  13680

tgtcactgtt ggcccagtta ttcaggagaa agatgtgaag tcaaccactg tagcaactac  13740

tgccagaatg gaggaacttg cgtaccatca gttctaggga gacccacctg cagctgtgca  13800

ctgggtttca ctgggccaaa ctgtggtaag acagtctgtg aggatttttg tcaaaatgga  13860

ggaacctgca ttgtgactgc tggaaaccag ccttactgcc actgccagcc ggaatacacc  13920

ggagacagat gtcagtacta cgtgtgccac cactattgtg tgaattctga atcatgtacc  13980

attggggatg atggaagtgt tgaatgtgtc tgtccaacgc gctatgaagg accaaaatgt  14040

gaggttgaca agtgtgtaag gtgccatggg gggcactgca ttataaataa agacagtgaa  14100

gatatatttt gcaactgcac taatggaaag attgcctcta gctgtcagtt atgtgatggc  14160

tactgttaca atggtggcac atgccagctg gaccccgaga caaatgtacc tgtgtgtcta  14220

tgctccacca actggtcagg cacacagtgt gaaaggccag ccccaaagag cagcaagtct  14280

gatcatatca gcacaagaag cattgccatc attgtgcctc tcgtcctctt ggtgactttg  14340

ataaccacct tagtaattgg tttagtgctt tgtaaaagaa aaagaaggac aaaaacaatt  14400

agaagacaac ctattatcaa tggaggaata aatgtagaaa ttggcaatcc atcttataac  14460

atgtatgagg tagatcatga tcacaacgat ggaggtcttt tagatcctgg ctttatgata  14520

gacccaacaa aggccaggta cataggggga ggacccagtg ctttcaagct tccacacaca  14580

gcgccgccca tctacctaaa ctctgatttg aaaggaccac taactgctgg gccaacaaat  14640

tactccaatc cggtatatgc aaaattatat atggatgggc aaaactgtcg aaactcctta  14700

ggaagtgttg atgaaaggaa agaactgctt ccaaagaaaa tagaaattgg tataagagag  14760

acagtggcat aatcagtgat atcttttata tgctgtataa atgtataaaa tataaggatt  14820

acttttgtat gttccaacag tattatactt gttttggcat cagcattacc tctttcttta  14880

tctttttcct ggttaattgt tttctgagtt ttttgggttt tattttttgc tgatgactat  14940

tgattgacca tttgtatggt atttttatga aaaagaactg cactacagta caatttacaa  15000

caatgctgct gatatgacac acctttgaat ttgttaaaat taaaaacaac gtattccttt  15060

gtagtgtgaa tatgagcaat ctattttata tgaacttttt tggttgtact taatcaacga  15120

ggagaatctc tgcacttttc cattatacgg tttgaaggct gtaatacagt gtcatattat  15180

ttttctgttt aaattgatgg aaaaatgatt gaatggtcaa ctctcttctt tgtgcccata  15240

aagatcgatt cagactctgc tgaaaatata tagctctcac aagttcagca tcacctgctt  15300

tgaaattagc cttagattgc caaccaatag atgagaattt tgaggaaaaa aattaaaaat  15360

atgtaaaatt aataatttgc atgaacacag atgactacat tttccaaaac ttagtggact  15420

ctatgtgatg tactaaatgt atacaccttg taagcaatag ttatatttag gtggtagaac  15480

atagcaaaaa tataaccgaa agttggccga ctgcacttgc tatggaataa gaccttttat  15540

tctccctcag tctcgagata aatagccagc ctagagcaca acagggcatt gggtacttgc  15600

atcttaggta tttcttccca gtcacatcca ttttgtggaa gattaaccca accccttaca  15660

ctacactgaa cactaaagaa taatatataa gcacacaaat tggtgacaga atttcaatta  15720

cgtgaacgca tcctctttgc taggtcaaaa aacaaagggc aaagcagaca ttttagtata  15780

cagagtgatt ggcaaatatt ttcaagattt aatatgagca acccattatt tgccctatcc  15840

aaaatatatt caagggcctt ccaagttgta gaagaacaat gatcttccca taatcaaaag  15900

tggagagtcg aaatgctgtg ccagttgctc tggtattcag gtttctctgg gttttacaga  15960

acgcatggac cccattcacg tttggtttgt ttatcttcaa atttgagttg aaacgagtgc  16020

gatttattta agttgtatat aaaaataaaa ggatagcatt tttatacaaa tatctttaaa  16080

ggcacaaaag atttattcac aagttttgga gggctttttg ttcctctgat agacatgact  16140

gacttttagc tgtcataatg tattaaccta acagatgaaa tatgttaaat atgtggttgc  16200

tctttatccc tttgtacaag cattaaaaaa actgctgttt tataagaaga ctttttgttg  16260

tactatgtgc atgcatacta cctatttcta aactttgcca tattgaggcc tttataaact  16320

attgatttat gtaatactag tgcaattttg cttgaacaat gttatgcata tcataaactt  16380

tttcaggttc ttgtttaagt acatttttta aattgaacag tatttttcat tttggttata  16440

atatagtcat tttgcctatg tttctacaat gaagtgttaa atactttata aaaaattgtt  16500

gactgactta tttaaatgaa attctacata taaaaaaaaa aaaaaaaaaa aaaaaaa     16557


<210>  172
<211>  4599
<212>  PRT
<213>  Homo sapiens

<400>  172

Met Ser Glu Phe Leu Leu Ala Leu Leu Thr Leu Ser Gly Leu Leu Pro 
1               5                   10                  15


Ile Ala Arg Val Leu Thr Val Gly Ala Asp Arg Asp Gln Gln Leu Cys 
            20                  25                  30


Asp Pro Gly Glu Phe Leu Cys His Asp His Val Thr Cys Val Ser Gln 
        35                  40                  45


Ser Trp Leu Cys Asp Gly Asp Pro Asp Cys Pro Asp Asp Ser Asp Glu 
    50                  55                  60


Ser Leu Asp Thr Cys Pro Glu Glu Val Glu Ile Lys Cys Pro Leu Asn 
65                  70                  75                  80


His Ile Ala Cys Leu Gly Thr Asn Lys Cys Val His Leu Ser Gln Leu 
                85                  90                  95


Cys Asn Gly Val Leu Asp Cys Pro Asp Gly Tyr Asp Glu Gly Val His 
            100                 105                 110


Cys Gln Glu Leu Leu Ser Asn Cys Gln Gln Leu Asn Cys Gln Tyr Lys 
        115                 120                 125


Cys Thr Met Val Arg Asn Ser Thr Arg Cys Tyr Cys Glu Asp Gly Phe 
    130                 135                 140


Glu Ile Thr Glu Asp Gly Arg Ser Cys Lys Asp Gln Asp Glu Cys Ala 
145                 150                 155                 160


Val Tyr Gly Thr Cys Ser Gln Thr Cys Arg Asn Thr His Gly Ser Tyr 
                165                 170                 175


Thr Cys Ser Cys Val Glu Gly Tyr Leu Met Gln Pro Asp Asn Arg Ser 
            180                 185                 190


Cys Lys Ala Lys Ile Glu Pro Thr Asp Arg Pro Pro Ile Leu Leu Ile 
        195                 200                 205


Ala Asn Phe Glu Thr Ile Glu Val Phe Tyr Leu Asn Gly Ser Lys Met 
    210                 215                 220


Ala Thr Leu Ser Ser Val Asn Gly Asn Glu Ile His Thr Leu Asp Phe 
225                 230                 235                 240


Ile Tyr Asn Glu Asp Met Ile Cys Trp Ile Glu Ser Arg Glu Ser Ser 
                245                 250                 255


Asn Gln Leu Lys Cys Ile Gln Ile Thr Lys Ala Gly Gly Leu Thr Asp 
            260                 265                 270


Glu Trp Thr Ile Asn Ile Leu Gln Ser Phe His Asn Val Gln Gln Met 
        275                 280                 285


Ala Ile Asp Trp Leu Thr Arg Asn Leu Tyr Phe Val Asp His Val Gly 
    290                 295                 300


Asp Arg Ile Phe Val Cys Asn Ser Asn Gly Ser Val Cys Val Thr Leu 
305                 310                 315                 320


Ile Asp Leu Glu Leu His Asn Pro Lys Ala Ile Ala Val Asp Pro Ile 
                325                 330                 335


Ala Gly Lys Leu Phe Phe Thr Asp Tyr Gly Asn Val Ala Lys Val Glu 
            340                 345                 350


Arg Cys Asp Met Asp Gly Met Asn Arg Thr Arg Ile Ile Asp Ser Lys 
        355                 360                 365


Thr Glu Gln Pro Ala Ala Leu Ala Leu Asp Leu Val Asn Lys Leu Val 
    370                 375                 380


Tyr Trp Val Asp Leu Tyr Leu Asp Tyr Val Gly Val Val Asp Tyr Gln 
385                 390                 395                 400


Gly Lys Asn Arg His Thr Val Ile Gln Gly Arg Gln Val Arg His Leu 
                405                 410                 415


Tyr Gly Ile Thr Val Phe Glu Asp Tyr Leu Tyr Ala Thr Asn Ser Asp 
            420                 425                 430


Asn Tyr Asn Ile Val Arg Ile Asn Arg Phe Asn Gly Thr Asp Ile His 
        435                 440                 445


Ser Leu Ile Lys Ile Glu Asn Ala Trp Gly Ile Arg Ile Tyr Gln Lys 
    450                 455                 460


Arg Thr Gln Pro Thr Val Arg Ser His Ala Cys Glu Val Asp Pro Tyr 
465                 470                 475                 480


Gly Met Pro Gly Gly Cys Ser His Ile Cys Leu Leu Ser Ser Ser Tyr 
                485                 490                 495


Lys Thr Arg Thr Cys Arg Cys Arg Thr Gly Phe Asn Leu Gly Ser Asp 
            500                 505                 510


Gly Arg Ser Cys Lys Arg Pro Lys Asn Glu Leu Phe Leu Phe Tyr Gly 
        515                 520                 525


Lys Gly Arg Pro Gly Ile Val Arg Gly Met Asp Leu Asn Thr Lys Ile 
    530                 535                 540


Ala Asp Glu Tyr Met Ile Pro Ile Glu Asn Leu Val Asn Pro Arg Ala 
545                 550                 555                 560


Leu Asp Phe His Ala Glu Thr Asn Tyr Ile Tyr Phe Ala Asp Thr Thr 
                565                 570                 575


Ser Phe Leu Ile Gly Arg Gln Lys Ile Asp Gly Thr Glu Arg Glu Thr 
            580                 585                 590


Ile Leu Lys Asp Asp Leu Asp Asn Val Glu Gly Ile Ala Val Asp Trp 
        595                 600                 605


Ile Gly Asn Asn Leu Tyr Trp Thr Asn Asp Gly His Arg Lys Thr Ile 
    610                 615                 620


Asn Val Ala Arg Leu Glu Lys Ala Ser Gln Ser Arg Lys Thr Leu Leu 
625                 630                 635                 640


Glu Gly Glu Met Ser His Pro Arg Gly Ile Val Val Asp Pro Val Asn 
                645                 650                 655


Gly Trp Met Tyr Trp Thr Asp Trp Glu Glu Asp Glu Ile Asp Asp Ser 
            660                 665                 670


Val Gly Arg Ile Glu Lys Ala Trp Met Asp Gly Phe Asn Arg Gln Ile 
        675                 680                 685


Phe Val Thr Ser Lys Met Leu Trp Pro Asn Gly Leu Thr Leu Asp Phe 
    690                 695                 700


His Thr Asn Thr Leu Tyr Trp Cys Asp Ala Tyr Tyr Asp His Ile Glu 
705                 710                 715                 720


Lys Val Phe Leu Asn Gly Thr His Arg Lys Ile Val Tyr Ser Gly Arg 
                725                 730                 735


Glu Leu Asn His Pro Phe Gly Leu Ser His His Gly Asn Tyr Val Phe 
            740                 745                 750


Trp Thr Asp Tyr Met Asn Gly Ser Ile Phe Gln Leu Asp Leu Ile Thr 
        755                 760                 765


Ser Glu Val Thr Leu Leu Arg His Glu Arg Pro Pro Leu Phe Gly Leu 
    770                 775                 780


Gln Ile Tyr Asp Pro Arg Lys Gln Gln Gly Asp Asn Met Cys Arg Val 
785                 790                 795                 800


Asn Asn Gly Gly Cys Ser Thr Leu Cys Leu Ala Ile Pro Gly Gly Arg 
                805                 810                 815


Val Cys Ala Cys Ala Asp Asn Gln Leu Leu Asp Glu Asn Gly Thr Thr 
            820                 825                 830


Cys Thr Phe Asn Pro Gly Glu Ala Leu Pro His Ile Cys Lys Ala Gly 
        835                 840                 845


Glu Phe Arg Cys Lys Asn Arg His Cys Ile Gln Ala Arg Trp Lys Cys 
    850                 855                 860


Asp Gly Asp Asp Asp Cys Leu Asp Gly Ser Asp Glu Asp Ser Val Asn 
865                 870                 875                 880


Cys Phe Asn His Ser Cys Pro Asp Asp Gln Phe Lys Cys Gln Asn Asn 
                885                 890                 895


Arg Cys Ile Pro Lys Arg Trp Leu Cys Asp Gly Ala Asn Asp Cys Gly 
            900                 905                 910


Ser Asn Glu Asp Glu Ser Asn Gln Thr Cys Thr Ala Arg Thr Cys Gln 
        915                 920                 925


Val Asp Gln Phe Ser Cys Gly Asn Gly Arg Cys Ile Pro Arg Ala Trp 
    930                 935                 940


Leu Cys Asp Arg Glu Asp Asp Cys Gly Asp Gln Thr Asp Glu Met Ala 
945                 950                 955                 960


Ser Cys Glu Phe Pro Thr Cys Glu Pro Leu Thr Gln Phe Val Cys Lys 
                965                 970                 975


Ser Gly Arg Cys Ile Ser Ser Lys Trp His Cys Asp Ser Asp Asp Asp 
            980                 985                 990


Cys Gly Asp Gly Ser Asp Glu Val Gly Cys Val His Ser Cys Phe Asp 
        995                 1000                1005


Asn Gln Phe Arg Cys Ser Ser Gly Arg Cys Ile Pro Gly His Trp Ala 
    1010                1015                1020


Cys Asp Gly Asp Asn Asp Cys Gly Asp Phe Ser Asp Glu Ala Gln Ile 
1025                1030                1035                1040


Asn Cys Thr Lys Glu Glu Ile His Ser Pro Ala Gly Cys Asn Gly Asn 
                1045                1050                1055


Glu Phe Gln Cys His Pro Asp Gly Asn Cys Val Pro Asp Leu Trp Arg 
            1060                1065                1070


Cys Asp Gly Glu Lys Asp Cys Glu Asp Gly Ser Asp Glu Lys Gly Cys 
        1075                1080                1085


Asn Gly Thr Ile Arg Leu Cys Asp His Lys Thr Lys Phe Ser Cys Trp 
    1090                1095                1100


Ser Thr Gly Arg Cys Ile Asn Lys Ala Trp Val Cys Asp Gly Asp Ile 
1105                1110                1115                1120


Asp Cys Glu Asp Gln Ser Asp Glu Asp Asp Cys Asp Ser Phe Leu Cys 
                1125                1130                1135


Gly Pro Pro Lys His Pro Cys Ala Asn Asp Thr Ser Val Cys Leu Gln 
            1140                1145                1150


Pro Glu Lys Leu Cys Asn Gly Lys Lys Asp Cys Pro Asp Gly Ser Asp 
        1155                1160                1165


Glu Gly Tyr Leu Cys Asp Glu Cys Ser Leu Asn Asn Gly Gly Cys Ser 
    1170                1175                1180


Asn His Cys Ser Val Val Pro Gly Arg Gly Ile Val Cys Ser Cys Pro 
1185                1190                1195                1200


Glu Gly Leu Gln Leu Asn Lys Asp Asn Lys Thr Cys Glu Ile Val Asp 
                1205                1210                1215


Tyr Cys Ser Asn His Leu Lys Cys Ser Gln Val Cys Glu Gln His Lys 
            1220                1225                1230


His Thr Val Lys Cys Ser Cys Tyr Glu Gly Trp Lys Leu Asp Val Asp 
        1235                1240                1245


Gly Glu Ser Cys Thr Ser Val Asp Pro Phe Glu Ala Phe Ile Ile Phe 
    1250                1255                1260


Ser Ile Arg His Glu Ile Arg Arg Ile Asp Leu His Lys Arg Asp Tyr 
1265                1270                1275                1280


Ser Leu Leu Val Pro Gly Leu Arg Asn Thr Ile Ala Leu Asp Phe His 
                1285                1290                1295


Phe Asn Gln Ser Leu Leu Tyr Trp Thr Asp Val Val Glu Asp Arg Ile 
            1300                1305                1310


Tyr Arg Gly Lys Leu Ser Glu Ser Gly Gly Val Ser Ala Ile Glu Val 
        1315                1320                1325


Val Val Glu His Gly Leu Ala Thr Pro Glu Gly Leu Thr Val Asp Trp 
    1330                1335                1340


Ile Ala Gly Asn Ile Tyr Trp Ile Asp Ser Asn Leu Asp Gln Ile Glu 
1345                1350                1355                1360


Val Ala Lys Leu Asp Gly Ser Leu Arg Thr Thr Leu Ile Ala Gly Ala 
                1365                1370                1375


Met Glu His Pro Arg Ala Ile Ala Leu Asp Pro Arg Tyr Gly Ile Leu 
            1380                1385                1390


Phe Trp Thr Asp Trp Asp Ala Asn Phe Pro Arg Ile Glu Ser Ala Ser 
        1395                1400                1405


Met Ser Gly Ala Gly Arg Lys Thr Ile Tyr Lys Asp Met Lys Thr Gly 
    1410                1415                1420


Ala Trp Pro Asn Gly Leu Thr Val Asp His Phe Glu Lys Arg Ile Val 
1425                1430                1435                1440


Trp Thr Asp Ala Arg Ser Asp Ala Ile Tyr Ser Ala Leu Tyr Asp Gly 
                1445                1450                1455


Thr Asn Met Ile Glu Ile Ile Arg Gly His Glu Tyr Leu Ser His Pro 
            1460                1465                1470


Phe Ala Val Ser Leu Tyr Gly Ser Glu Val Tyr Trp Thr Asp Trp Arg 
        1475                1480                1485


Thr Asn Thr Leu Ser Lys Ala Asn Lys Trp Thr Gly Gln Asn Val Ser 
    1490                1495                1500


Val Ile Gln Lys Thr Ser Ala Gln Pro Phe Asp Leu Gln Ile Tyr His 
1505                1510                1515                1520


Pro Ser Arg Gln Pro Gln Ala Pro Asn Pro Cys Ala Ala Asn Asp Gly 
                1525                1530                1535


Lys Gly Pro Cys Ser His Met Cys Leu Ile Asn His Asn Arg Ser Ala 
            1540                1545                1550


Ala Cys Ala Cys Pro His Leu Met Lys Leu Ser Ser Asp Lys Lys Thr 
        1555                1560                1565


Cys Tyr Glu Met Lys Lys Phe Leu Leu Tyr Ala Arg Arg Ser Glu Ile 
    1570                1575                1580


Arg Gly Val Asp Ile Asp Asn Pro Tyr Phe Asn Phe Ile Thr Ala Phe 
1585                1590                1595                1600


Thr Val Pro Asp Ile Asp Asp Val Thr Val Ile Asp Phe Asp Ala Ser 
                1605                1610                1615


Glu Glu Arg Leu Tyr Trp Thr Asp Ile Lys Thr Gln Thr Ile Lys Arg 
            1620                1625                1630


Ala Phe Ile Asn Gly Thr Gly Leu Glu Thr Val Ile Ser Arg Asp Ile 
        1635                1640                1645


Gln Ser Ile Arg Gly Leu Ala Val Asp Trp Val Ser Arg Asn Leu Tyr 
    1650                1655                1660


Trp Ile Ser Ser Glu Phe Asp Glu Thr Gln Ile Asn Val Ala Arg Leu 
1665                1670                1675                1680


Asp Gly Ser Leu Lys Thr Ser Ile Ile His Gly Ile Asp Lys Pro Gln 
                1685                1690                1695


Cys Leu Ala Ala His Pro Val Arg Gly Lys Leu Tyr Trp Thr Asp Gly 
            1700                1705                1710


Asn Thr Ile Asn Met Ala Asn Met Asp Gly Ser Asn Ser Lys Ile Leu 
        1715                1720                1725


Phe Gln Asn Gln Lys Glu Pro Val Gly Leu Ser Ile Asp Tyr Val Glu 
    1730                1735                1740


Asn Lys Leu Tyr Trp Ile Ser Ser Gly Asn Gly Thr Ile Asn Arg Cys 
1745                1750                1755                1760


Asn Leu Asp Gly Gly Asn Leu Glu Val Ile Glu Ser Met Lys Glu Glu 
                1765                1770                1775


Leu Thr Lys Ala Thr Ala Leu Thr Ile Met Asp Lys Lys Leu Trp Trp 
            1780                1785                1790


Ala Asp Gln Asn Leu Ala Gln Leu Gly Thr Cys Ser Lys Arg Asp Gly 
        1795                1800                1805


Arg Asn Pro Thr Ile Leu Arg Asn Lys Thr Ser Gly Val Val His Met 
    1810                1815                1820


Lys Val Tyr Asp Lys Glu Ala Gln Gln Gly Ser Asn Ser Cys Gln Leu 
1825                1830                1835                1840


Asn Asn Gly Gly Cys Ser Gln Leu Cys Leu Pro Thr Ser Glu Thr Thr 
                1845                1850                1855


Arg Thr Cys Met Cys Thr Val Gly Tyr Tyr Leu Gln Lys Asn Arg Met 
            1860                1865                1870


Ser Cys Gln Gly Ile Glu Ser Phe Leu Met Tyr Ser Val His Glu Gly 
        1875                1880                1885


Ile Arg Gly Ile Pro Leu Glu Pro Ser Asp Lys Met Asp Ala Leu Met 
    1890                1895                1900


Pro Ile Ser Gly Thr Ser Phe Ala Val Gly Ile Asp Phe His Ala Glu 
1905                1910                1915                1920


Asn Asp Thr Ile Tyr Trp Thr Asp Met Gly Phe Asn Lys Ile Ser Arg 
                1925                1930                1935


Ala Lys Arg Asp Gln Thr Trp Lys Glu Asp Ile Ile Thr Asn Gly Leu 
            1940                1945                1950


Gly Arg Val Glu Gly Ile Ala Val Asp Trp Ile Ala Gly Asn Ile Tyr 
        1955                1960                1965


Trp Thr Asp His Gly Phe Asn Leu Ile Glu Val Ala Arg Leu Asn Gly 
    1970                1975                1980


Ser Phe Arg Tyr Val Ile Ile Ser Gln Gly Leu Asp Gln Pro Arg Ser 
1985                1990                1995                2000


Ile Ala Val His Pro Glu Lys Gly Leu Leu Phe Trp Thr Glu Trp Gly 
                2005                2010                2015


Gln Met Pro Cys Ile Gly Lys Ala Arg Leu Asp Gly Ser Glu Lys Val 
            2020                2025                2030


Val Leu Val Ser Met Gly Ile Ala Trp Pro Asn Gly Ile Ser Ile Asp 
        2035                2040                2045


Tyr Glu Glu Asn Lys Leu Tyr Trp Cys Asp Ala Arg Thr Asp Lys Ile 
    2050                2055                2060


Glu Arg Ile Asp Leu Glu Thr Gly Gly Asn Arg Glu Met Val Leu Ser 
2065                2070                2075                2080


Gly Ser Asn Val Asp Met Phe Ser Val Ala Val Phe Gly Ala Tyr Ile 
                2085                2090                2095


Tyr Trp Ser Asp Arg Ala His Ala Asn Gly Ser Val Arg Arg Gly His 
            2100                2105                2110


Lys Asn Asp Ala Thr Glu Thr Ile Thr Met Arg Thr Gly Leu Gly Val 
        2115                2120                2125


Asn Leu Lys Glu Val Lys Ile Phe Asn Arg Val Arg Glu Lys Gly Thr 
    2130                2135                2140


Asn Val Cys Ala Arg Asp Asn Gly Gly Cys Lys Gln Leu Cys Leu Tyr 
2145                2150                2155                2160


Arg Gly Asn Ser Arg Arg Thr Cys Ala Cys Ala His Gly Tyr Leu Ala 
                2165                2170                2175


Glu Asp Gly Val Thr Cys Leu Arg His Glu Gly Tyr Leu Leu Tyr Ser 
            2180                2185                2190


Gly Arg Thr Ile Leu Lys Ser Ile His Leu Ser Asp Glu Thr Asn Leu 
        2195                2200                2205


Asn Ser Pro Ile Arg Pro Tyr Glu Asn Pro Arg Tyr Phe Lys Asn Val 
    2210                2215                2220


Ile Ala Leu Ala Phe Asp Tyr Asn Gln Arg Arg Lys Gly Thr Asn Arg 
2225                2230                2235                2240


Ile Phe Tyr Ser Asp Ala His Phe Gly Asn Ile Gln Leu Ile Lys Asp 
                2245                2250                2255


Asn Trp Glu Asp Arg Gln Val Ile Val Glu Asn Val Gly Ser Val Glu 
            2260                2265                2270


Gly Leu Ala Tyr His Arg Ala Trp Asp Thr Leu Tyr Trp Thr Ser Ser 
        2275                2280                2285


Thr Thr Ser Ser Ile Thr Arg His Thr Val Asp Gln Thr Arg Pro Gly 
    2290                2295                2300


Ala Phe Asp Arg Glu Ala Val Ile Thr Met Ser Glu Asp Asp His Pro 
2305                2310                2315                2320


His Val Leu Ala Leu Asp Glu Cys Gln Asn Leu Met Phe Trp Thr Asn 
                2325                2330                2335


Trp Asn Glu Gln His Pro Ser Ile Met Arg Ser Thr Leu Thr Gly Lys 
            2340                2345                2350


Asn Ala Gln Val Val Val Ser Thr Asp Ile Leu Thr Pro Asn Gly Leu 
        2355                2360                2365


Thr Ile Asp Tyr Arg Ala Glu Lys Leu Tyr Phe Ser Asp Gly Ser Leu 
    2370                2375                2380


Gly Lys Ile Glu Arg Cys Glu Tyr Asp Gly Ser Gln Arg His Val Ile 
2385                2390                2395                2400


Val Lys Ser Gly Pro Gly Thr Phe Leu Ser Leu Ala Val Tyr Asp Asn 
                2405                2410                2415


Tyr Ile Phe Trp Ser Asp Trp Gly Arg Arg Ala Ile Leu Arg Ser Asn 
            2420                2425                2430


Lys Tyr Thr Gly Gly Asp Thr Lys Ile Leu Arg Ser Asp Ile Pro His 
        2435                2440                2445


Gln Pro Met Gly Ile Ile Ala Val Ala Asn Asp Thr Asn Ser Cys Glu 
    2450                2455                2460


Leu Ser Pro Cys Ala Leu Leu Asn Gly Gly Cys His Asp Leu Cys Leu 
2465                2470                2475                2480


Leu Thr Pro Asn Gly Arg Val Asn Cys Ser Cys Arg Gly Asp Arg Ile 
                2485                2490                2495


Leu Leu Glu Asp Asn Arg Cys Val Thr Lys Asn Ser Ser Cys Asn Ala 
            2500                2505                2510


Tyr Ser Glu Phe Glu Cys Gly Asn Gly Glu Cys Ile Asp Tyr Gln Leu 
        2515                2520                2525


Thr Cys Asp Gly Ile Pro His Cys Lys Asp Lys Ser Asp Glu Lys Leu 
    2530                2535                2540


Leu Tyr Cys Glu Asn Arg Ser Cys Arg Arg Gly Phe Lys Pro Cys Tyr 
2545                2550                2555                2560


Asn Arg Arg Cys Ile Pro His Gly Lys Leu Cys Asp Gly Glu Asn Asp 
                2565                2570                2575


Cys Gly Asp Asn Ser Asp Glu Leu Asp Cys Lys Val Ser Thr Cys Ala 
            2580                2585                2590


Thr Val Glu Phe Arg Cys Ala Asp Gly Thr Cys Ile Pro Arg Ser Ala 
        2595                2600                2605


Arg Cys Asn Gln Asn Ile Asp Cys Ala Asp Ala Ser Asp Glu Lys Asn 
    2610                2615                2620


Cys Asn Asn Thr Asp Cys Thr His Phe Tyr Lys Leu Gly Val Lys Thr 
2625                2630                2635                2640


Thr Gly Phe Ile Arg Cys Asn Ser Thr Ser Leu Cys Val Leu Pro Thr 
                2645                2650                2655


Trp Ile Cys Asp Gly Ser Asn Asp Cys Gly Asp Tyr Ser Asp Glu Leu 
            2660                2665                2670


Lys Cys Pro Val Gln Asn Lys His Lys Cys Glu Glu Asn Tyr Phe Ser 
        2675                2680                2685


Cys Pro Ser Gly Arg Cys Ile Leu Asn Thr Trp Ile Cys Asp Gly Gln 
    2690                2695                2700


Lys Asp Cys Glu Asp Gly Arg Asp Glu Phe His Cys Asp Ser Ser Cys 
2705                2710                2715                2720


Ser Trp Asn Gln Phe Ala Cys Ser Ala Gln Lys Cys Ile Ser Lys His 
                2725                2730                2735


Trp Ile Cys Asp Gly Glu Asp Asp Cys Gly Asp Gly Leu Asp Glu Ser 
            2740                2745                2750


Asp Ser Ile Cys Gly Ala Ile Thr Cys Ala Ala Asp Met Phe Ser Cys 
        2755                2760                2765


Gln Gly Ser Arg Ala Cys Val Pro Arg His Trp Leu Cys Asp Gly Glu 
    2770                2775                2780


Arg Asp Cys Pro Asp Gly Ser Asp Glu Leu Ser Thr Ala Gly Cys Ala 
2785                2790                2795                2800


Pro Asn Asn Thr Cys Asp Glu Asn Ala Phe Met Cys His Asn Lys Val 
                2805                2810                2815


Cys Ile Pro Lys Gln Phe Val Cys Asp His Asp Asp Asp Cys Gly Asp 
            2820                2825                2830


Gly Ser Asp Glu Ser Pro Gln Cys Gly Tyr Arg Gln Cys Gly Thr Glu 
        2835                2840                2845


Glu Phe Ser Cys Ala Asp Gly Arg Cys Leu Leu Asn Thr Gln Trp Gln 
    2850                2855                2860


Cys Asp Gly Asp Phe Asp Cys Pro Asp His Ser Asp Glu Ala Pro Leu 
2865                2870                2875                2880


Asn Pro Lys Cys Lys Ser Ala Glu Gln Ser Cys Asn Ser Ser Phe Phe 
                2885                2890                2895


Met Cys Lys Asn Gly Arg Cys Ile Pro Ser Gly Gly Leu Cys Asp Asn 
            2900                2905                2910


Lys Asp Asp Cys Gly Asp Gly Ser Asp Glu Arg Asn Cys His Ile Asn 
        2915                2920                2925


Glu Cys Leu Ser Lys Lys Val Ser Gly Cys Ser Gln Asp Cys Gln Asp 
    2930                2935                2940


Leu Pro Val Ser Tyr Lys Cys Lys Cys Trp Pro Gly Phe Gln Leu Lys 
2945                2950                2955                2960


Asp Asp Gly Lys Thr Cys Val Asp Ile Asp Glu Cys Ser Ser Gly Phe 
                2965                2970                2975


Pro Cys Ser Gln Gln Cys Ile Asn Thr Tyr Gly Thr Tyr Lys Cys Leu 
            2980                2985                2990


Cys Thr Asp Gly Tyr Glu Ile Gln Pro Asp Asn Pro Asn Gly Cys Lys 
        2995                3000                3005


Ser Leu Ser Asp Glu Glu Pro Phe Leu Ile Leu Ala Asp His His Glu 
    3010                3015                3020


Ile Arg Lys Ile Ser Thr Asp Gly Ser Asn Tyr Thr Leu Leu Lys Gln 
3025                3030                3035                3040


Gly Leu Asn Asn Val Ile Ala Ile Asp Phe Asp Tyr Arg Glu Glu Phe 
                3045                3050                3055


Ile Tyr Trp Ile Asp Ser Ser Arg Pro Asn Gly Ser Arg Ile Asn Arg 
            3060                3065                3070


Met Cys Leu Asn Gly Ser Asp Ile Lys Val Val His Asn Thr Ala Val 
        3075                3080                3085


Pro Asn Ala Leu Ala Val Asp Trp Ile Gly Lys Asn Leu Tyr Trp Ser 
    3090                3095                3100


Asp Thr Glu Lys Arg Ile Ile Glu Val Ser Lys Leu Asn Gly Leu Tyr 
3105                3110                3115                3120


Pro Thr Ile Leu Val Ser Lys Arg Leu Lys Phe Pro Arg Asp Leu Ser 
                3125                3130                3135


Leu Asp Pro Gln Ala Gly Tyr Leu Tyr Trp Ile Asp Cys Cys Glu Tyr 
            3140                3145                3150


Pro His Ile Gly Arg Val Gly Met Asp Gly Thr Asn Gln Ser Val Val 
        3155                3160                3165


Ile Glu Thr Lys Ile Ser Arg Pro Met Ala Leu Thr Ile Asp Tyr Val 
    3170                3175                3180


Asn Arg Arg Leu Tyr Trp Ala Asp Glu Asn His Ile Glu Phe Ser Asn 
3185                3190                3195                3200


Met Asp Gly Ser His Arg His Lys Val Pro Asn Gln Asp Ile Pro Gly 
                3205                3210                3215


Val Ile Ala Leu Thr Leu Phe Glu Asp Tyr Ile Tyr Trp Thr Asp Gly 
            3220                3225                3230


Lys Thr Lys Ser Leu Ser Arg Ala His Lys Thr Ser Gly Ala Asp Arg 
        3235                3240                3245


Leu Ser Leu Ile Tyr Ser Trp His Ala Ile Thr Asp Ile Gln Val Tyr 
    3250                3255                3260


His Ser Tyr Arg Gln Pro Asp Val Ser Lys His Leu Cys Met Ile Asn 
3265                3270                3275                3280


Asn Gly Gly Cys Ser His Leu Cys Leu Leu Ala Pro Gly Lys Thr His 
                3285                3290                3295


Thr Cys Ala Cys Pro Thr Asn Phe Tyr Leu Ala Ala Asp Asn Arg Thr 
            3300                3305                3310


Cys Leu Ser Asn Cys Thr Ala Ser Gln Phe Arg Cys Lys Thr Asp Lys 
        3315                3320                3325


Cys Ile Pro Phe Trp Trp Lys Cys Asp Thr Val Asp Asp Cys Gly Asp 
    3330                3335                3340


Gly Ser Asp Glu Pro Asp Asp Cys Pro Glu Phe Arg Cys Gln Pro Gly 
3345                3350                3355                3360


Arg Phe Gln Cys Gly Thr Gly Leu Cys Ala Leu Pro Ala Phe Ile Cys 
                3365                3370                3375


Asp Gly Glu Asn Asp Cys Gly Asp Asn Ser Asp Glu Leu Asn Cys Asp 
            3380                3385                3390


Thr His Val Cys Leu Ser Gly Gln Phe Lys Cys Thr Lys Asn Gln Lys 
        3395                3400                3405


Cys Ile Pro Val Asn Leu Arg Cys Asn Gly Gln Asp Asp Cys Gly Asp 
    3410                3415                3420


Glu Glu Asp Glu Arg Asp Cys Pro Glu Asn Ser Cys Ser Pro Asp Tyr 
3425                3430                3435                3440


Phe Gln Cys Lys Thr Thr Lys His Cys Ile Ser Lys Leu Trp Val Cys 
                3445                3450                3455


Asp Glu Asp Pro Asp Cys Ala Asp Ala Ser Asp Glu Ala Asn Cys Asp 
            3460                3465                3470


Lys Lys Thr Cys Gly Pro His Glu Phe Gln Cys Lys Asn Asn Asn Cys 
        3475                3480                3485


Ile Pro Asp His Trp Arg Cys Asp Ser Gln Asn Asp Cys Ser Asp Asn 
    3490                3495                3500


Ser Asp Glu Glu Asn Cys Lys Pro Gln Thr Cys Thr Leu Lys Asp Phe 
3505                3510                3515                3520


Leu Cys Ala Asn Gly Asp Cys Val Ser Ser Arg Phe Trp Cys Asp Gly 
                3525                3530                3535


Asp Phe Asp Cys Ala Asp Gly Ser Asp Glu Arg Asn Cys Glu Thr Ser 
            3540                3545                3550


Cys Ser Lys Asp Gln Phe Arg Cys Ser Asn Gly Gln Cys Ile Pro Ala 
        3555                3560                3565


Lys Trp Lys Cys Asp Gly His Glu Asp Cys Lys Tyr Gly Glu Asp Glu 
    3570                3575                3580


Lys Ser Cys Glu Pro Ala Ser Pro Thr Cys Ser Ser Arg Glu Tyr Ile 
3585                3590                3595                3600


Cys Ala Ser Asp Gly Cys Ile Ser Ala Ser Leu Lys Cys Asn Gly Glu 
                3605                3610                3615


Tyr Asp Cys Ala Asp Gly Ser Asp Glu Met Asp Cys Val Thr Glu Cys 
            3620                3625                3630


Lys Glu Asp Gln Phe Arg Cys Lys Asn Lys Ala His Cys Ile Pro Ile 
        3635                3640                3645


Arg Trp Leu Cys Asp Gly Ile His Asp Cys Val Asp Gly Ser Asp Glu 
    3650                3655                3660


Glu Asn Cys Glu Arg Gly Gly Asn Ile Cys Arg Ala Asp Glu Phe Leu 
3665                3670                3675                3680


Cys Asn Asn Ser Leu Cys Lys Leu His Phe Trp Val Cys Asp Gly Glu 
                3685                3690                3695


Asp Asp Cys Gly Asp Asn Ser Asp Glu Ala Pro Asp Met Cys Val Lys 
            3700                3705                3710


Phe Leu Cys Pro Ser Thr Arg Pro His Arg Cys Arg Asn Asn Arg Ile 
        3715                3720                3725


Cys Leu Gln Ser Glu Gln Met Cys Asn Gly Ile Asp Glu Cys Gly Asp 
    3730                3735                3740


Asn Ser Asp Glu Asp His Cys Gly Gly Lys Leu Thr Tyr Lys Ala Arg 
3745                3750                3755                3760


Pro Cys Lys Lys Asp Glu Phe Ala Cys Ser Asn Lys Lys Cys Ile Pro 
                3765                3770                3775


Met Asp Leu Gln Cys Asp Arg Leu Asp Asp Cys Gly Asp Gly Ser Asp 
            3780                3785                3790


Glu Gln Gly Cys Arg Ile Ala Pro Thr Glu Tyr Thr Cys Glu Asp Asn 
        3795                3800                3805


Val Asn Pro Cys Gly Asp Asp Ala Tyr Cys Asn Gln Ile Lys Thr Ser 
    3810                3815                3820


Val Phe Cys Arg Cys Lys Pro Gly Phe Gln Arg Asn Met Lys Asn Arg 
3825                3830                3835                3840


Gln Cys Glu Asp Leu Asn Glu Cys Leu Val Phe Gly Thr Cys Ser His 
                3845                3850                3855


Gln Cys Ile Asn Val Glu Gly Ser Tyr Lys Cys Val Cys Asp Gln Asn 
            3860                3865                3870


Phe Gln Glu Arg Asn Asn Thr Cys Ile Ala Glu Gly Ser Glu Asp Gln 
        3875                3880                3885


Val Leu Tyr Ile Ala Asn Asp Thr Asp Ile Leu Gly Phe Ile Tyr Pro 
    3890                3895                3900


Phe Asn Tyr Ser Gly Asp His Gln Gln Ile Ser His Ile Glu His Asn 
3905                3910                3915                3920


Ser Arg Ile Thr Gly Met Asp Val Tyr Tyr Gln Arg Asp Met Ile Ile 
                3925                3930                3935


Trp Ser Thr Gln Phe Asn Pro Gly Gly Ile Phe Tyr Lys Arg Ile His 
            3940                3945                3950


Gly Arg Glu Lys Arg Gln Ala Asn Ser Gly Leu Ile Cys Pro Glu Phe 
        3955                3960                3965


Lys Arg Pro Arg Asp Ile Ala Val Asp Trp Val Ala Gly Asn Ile Tyr 
    3970                3975                3980


Trp Thr Asp His Ser Arg Met His Trp Phe Ser Tyr Tyr Thr Thr His 
3985                3990                3995                4000


Trp Thr Ser Leu Arg Tyr Ser Ile Asn Val Gly Gln Leu Asn Gly Pro 
                4005                4010                4015


Asn Cys Thr Arg Leu Leu Thr Asn Met Ala Gly Glu Pro Tyr Ala Ile 
            4020                4025                4030


Ala Val Asn Pro Lys Arg Gly Met Met Tyr Trp Thr Val Val Gly Asp 
        4035                4040                4045


His Ser His Ile Glu Glu Ala Ala Met Asp Gly Thr Leu Arg Arg Ile 
    4050                4055                4060


Leu Val Gln Lys Asn Leu Gln Arg Pro Thr Gly Leu Ala Val Asp Tyr 
4065                4070                4075                4080


Phe Ser Glu Arg Ile Tyr Trp Ala Asp Phe Glu Leu Ser Ile Ile Gly 
                4085                4090                4095


Ser Val Leu Tyr Asp Gly Ser Asn Ser Val Val Ser Val Ser Ser Lys 
            4100                4105                4110


Gln Gly Leu Leu His Pro His Arg Ile Asp Ile Phe Glu Asp Tyr Ile 
        4115                4120                4125


Tyr Gly Ala Gly Pro Lys Asn Gly Val Phe Arg Val Gln Lys Phe Gly 
    4130                4135                4140


His Gly Ser Val Glu Tyr Leu Ala Leu Asn Ile Asp Lys Thr Lys Gly 
4145                4150                4155                4160


Val Leu Ile Ser His Arg Tyr Lys Gln Leu Asp Leu Pro Asn Pro Cys 
                4165                4170                4175


Leu Asp Leu Ala Cys Glu Phe Leu Cys Leu Leu Asn Pro Ser Gly Ala 
            4180                4185                4190


Thr Cys Val Cys Pro Glu Gly Lys Tyr Leu Ile Asn Gly Thr Cys Asn 
        4195                4200                4205


Asp Asp Ser Leu Leu Asp Asp Ser Cys Lys Leu Thr Cys Glu Asn Gly 
    4210                4215                4220


Gly Arg Cys Ile Leu Asn Glu Lys Gly Asp Leu Arg Cys His Cys Trp 
4225                4230                4235                4240


Pro Ser Tyr Ser Gly Glu Arg Cys Glu Val Asn His Cys Ser Asn Tyr 
                4245                4250                4255


Cys Gln Asn Gly Gly Thr Cys Val Pro Ser Val Leu Gly Arg Pro Thr 
            4260                4265                4270


Cys Ser Cys Ala Leu Gly Phe Thr Gly Pro Asn Cys Gly Lys Thr Val 
        4275                4280                4285


Cys Glu Asp Phe Cys Gln Asn Gly Gly Thr Cys Ile Val Thr Ala Gly 
    4290                4295                4300


Asn Gln Pro Tyr Cys His Cys Gln Pro Glu Tyr Thr Gly Asp Arg Cys 
4305                4310                4315                4320


Gln Tyr Tyr Val Cys His His Tyr Cys Val Asn Ser Glu Ser Cys Thr 
                4325                4330                4335


Ile Gly Asp Asp Gly Ser Val Glu Cys Val Cys Pro Thr Arg Tyr Glu 
            4340                4345                4350


Gly Pro Lys Cys Glu Val Asp Lys Cys Val Arg Cys His Gly Gly His 
        4355                4360                4365


Cys Ile Ile Asn Lys Asp Ser Glu Asp Ile Phe Cys Asn Cys Thr Asn 
    4370                4375                4380


Gly Lys Ile Ala Ser Ser Cys Gln Leu Cys Asp Gly Tyr Cys Tyr Asn 
4385                4390                4395                4400


Gly Gly Thr Cys Gln Leu Asp Pro Glu Thr Asn Val Pro Val Cys Leu 
                4405                4410                4415


Cys Ser Thr Asn Trp Ser Gly Thr Gln Cys Glu Arg Pro Ala Pro Lys 
            4420                4425                4430


Ser Ser Lys Ser Asp His Ile Ser Thr Arg Ser Ile Ala Ile Ile Val 
        4435                4440                4445


Pro Leu Val Leu Leu Val Thr Leu Ile Thr Thr Leu Val Ile Gly Leu 
    4450                4455                4460


Val Leu Cys Lys Arg Lys Arg Arg Thr Lys Thr Ile Arg Arg Gln Pro 
4465                4470                4475                4480


Ile Ile Asn Gly Gly Ile Asn Val Glu Ile Gly Asn Pro Ser Tyr Asn 
                4485                4490                4495


Met Tyr Glu Val Asp His Asp His Asn Asp Gly Gly Leu Leu Asp Pro 
            4500                4505                4510


Gly Phe Met Ile Asp Pro Thr Lys Ala Arg Tyr Ile Gly Gly Gly Pro 
        4515                4520                4525


Ser Ala Phe Lys Leu Pro His Thr Ala Pro Pro Ile Tyr Leu Asn Ser 
    4530                4535                4540


Asp Leu Lys Gly Pro Leu Thr Ala Gly Pro Thr Asn Tyr Ser Asn Pro 
4545                4550                4555                4560


Val Tyr Ala Lys Leu Tyr Met Asp Gly Gln Asn Cys Arg Asn Ser Leu 
                4565                4570                4575


Gly Ser Val Asp Glu Arg Lys Glu Leu Leu Pro Lys Lys Ile Glu Ile 
            4580                4585                4590


Gly Ile Arg Glu Thr Val Ala 
        4595


<210>  173
<211>  4535
<212>  DNA
<213>  Homo sapiens

<400>  173
gggtttgaaa ttccaacatg gcagaggctg cagtccgtct tcccttcaaa aacttggaat     60

gatttcaaat cataggcacc ttcacttaac cctagcttcc attcatcagc aaacacatcg    120

gatcgatgct acgctaacct atcgggttct ctctccgcgc gttcaggtta aatgaatacc    180

tgacgaaagg gcccacgttt caaggcagtg acatttgata gctgagagga aaagtggctt    240

taatgaaaag caacctttgg aattcctgct tgtgagaaat ccaattcagc tttttgtgct    300

gccagcaaga aatgatcagt agcaccagtg tttatggctt gaagatgcag tggacgccag    360

agcatgccca gtggccagaa cagcactttg acatcacctc aaccactcgg tctcctgccc    420

acaaagttga agcctacaga ggtcatctgc agcgcaccta tcagtacgcc tgggcgaatg    480

atgacatatc tgctctgact gcatccaacc tactaaaaaa atatgcagag aagtattccg    540

gcattttgga aggtcctgtg gaccgacccg tactcagcaa ctattcggac acaccatcag    600

gactagtgaa cggtcggaaa aatgaaagtg aaccctggca gccttccttg aattcagaag    660

ctgtttatcc catgaactgt gttccggatg ttatcactgc cagcaaagct ggagtcagtt    720

cagccctccc tccagcagat gtctctgcga gtataggaag ctctcctggg gtagccagca    780

acctgacaga acctagttat tcaagtagta cctgtggaag ccacactgta cccagtcttc    840

atgcagggct cccatctcag gaatatgccc caggatacaa cggatcatat ttgcattcta    900

cttatagtag ccagccagca cctgcacttc cttcacctca tccgtctcct ttgcatagct    960

ctgggctact acagccccca ccaccacctc ctccgccacc agccttggtc ccaggctaca   1020

atgggacttc taacctctcc agttacagct atccgtctgc tagctatcct cctcagactg   1080

ctgtggggtc tgggtacagc cctggggggg caccgcctcc gccttcagcg tacctgcctt   1140

caggaattcc tgctcccacc cccctacccc ccaccactgt tcctggctac acctaccagg   1200

gccatggttt gacacctatt gcaccgtcgg ctctgacaaa cagttcagca agttctctca   1260

aaaggaaagc tttctacatg gcagggcaag gagatatgga ctccagttat ggaaattaca   1320

gctatggcca acagagatct acacagagtc ctatgtacag aatgcccgac aacagcattt   1380

caaacacaaa tcgggggaat ggctttgaca gaagtgctga aacatcatcc ttagcattta   1440

agccaacgaa gcagctaatg tcctctgaac agcaaaggaa attcagcagc cagtccagta   1500

gggctctgac ccctccttcc tacagtactg ctaaaaattc attgggatca agatccagtg   1560

aatcctttgg gaagtacaca tcgccagtaa tgagtgagca tggggacgag cacaggcagc   1620

tcctctctca cccaatgcaa ggccctggac tccgtgcagc tacctcatcc aaccactctg   1680

tggacgagca actgaagaat actgacacgc acctcatcga cctggtaacc aatgagatta   1740

tcacccaagg acctccagtg gactggaatg acattgctgg tctcgacctg gtgaaggctg   1800

tcattaaaga ggaggtttta tggccagtgt tgaggtcaga cgcgttcagt ggactgacgg   1860

ccttacctcg gagcatcctt ttatttggac ctcgggggac aggcaaaaca ttattgggca   1920

gatgcatcgc tagtcagctg ggggccacat ttttcaaaat tgccggttct ggactagtcg   1980

ccaagtggtt aggagaagca gagaaaatta tccatgcctc ttttcttgtg gccaggtgtc   2040

gccagccctc ggtgattttt gttagtgaca ttgacatgct tctctcctct caagtgaatg   2100

aggaacatag tccagtcagt cggatgagaa ccgaatttct gatgcaactg gacactgtac   2160

taacttcggc tgaggaccaa atcgtagtaa tttgtgccac cagtaaacca gaagaaatag   2220

atgaatccct tcggaggtac ttcatgaaac gacttttaat cccacttcct gacagcacag   2280

cgaggcacca gataatagta caactgctct cacagcacaa ttactgtctc aatgacaagg   2340

agtttgcact gctcgtccag cgcacagaag gcttttctgg actagatgtg gctcatttgt   2400

gtcaggaagc agtggtgggc cccctccatg ccatgccagc cacagacctt tcagccatta   2460

tgcccagcca gttgaggccc gttacatatc aagactttga aaatgctttc tgcaagattc   2520

agcctagcat atctcaaaag gagcttgata tgtatgttga atggaacaaa atgtttggtt   2580

gcagtcagtg ataacttctt tagaaaaaaa aaatgtaatg aatgttggca cacacacata   2640

aaacctgcta catagggaat agagcccctt tccagtagag tttaaattgc aaagggtact   2700

ggggaagatg acgattaagt tgcatcttta gagtcagggt agatttggag gaaaagtgca   2760

tcaaatgaga gcttctgatt tgaaagcccc agatgacaga aagcatatgt ggatgctcag   2820

ttctgttcaa gctagacaac actcaccaag gagcaaggtg caagtgtgtt gatttcagaa   2880

ggacatgaac ctcgtgtgtt gattccattc tgctgttctc gagatttagt tgctgtcaag   2940

tgcctggagt ggtgctttat tttttgtttg cctcacaatt acattggtgg catgtgctaa   3000

tataaagagc tttaacttca aacattattg gactaaagag atgaacagtt gtgttatgac   3060

agaaaaccag atttttgcca ttttaagagc aacagtattc ctcaatcctg tctgttctgc   3120

agtattaagc taagaacagg taaaacaggg taacggtaat ctggacctta atttctgcag   3180

ttcatttctt ttaatgttct tgtctgcaaa aactcaggaa agtgattgtg atttgtacag   3240

tacctcaaag gaatgtgttg aaagcactat gtactgctga gagtaatagg ataggcttca   3300

atgttacttt atattaaaat gtatgtttac ctcaacaatt ggaaaatagc aaggaaaatt   3360

actttgaatg tatccagaaa aatactgaag tgtgatacaa ctgaatattt acagtttaaa   3420

gtagaaatgg aaggattttt ttaagttctt ttactaatta tggggaatta accagagcag   3480

aataattctt tatgtcaata actgcaagag ttcttagtac attgctcctt gataattaag   3540

tgaaaatgtt cttaaaaggt acactggtta attgaaagct acttattcag tttgtgttag   3600

tgtctagacc tgtcagccac aagacctgtt taggaccctg aaagtcacag tacctaaaaa   3660

ctatgactgc ctttttattg cataggtggt agtggtggtg atggtggtgg tagtttgcaa   3720

gttatctctt aaaactgctg ggaatggtgt cattctattc actaatctag cttatagact   3780

tgccgtgctg tttgatagaa tgcagaggat agcaaccaaa acaaatacac aaataaataa   3840

aaacaaaaac caaccaacaa accaacttac atacacatat atatatccac aaagaacctc   3900

tccatctcct ccccttcttt ttgactccac tcttgtcagt gcaattttgc ttctcatttt   3960

gaaatctggg ctgtagtgct cctgctttat ttctacctca gttttgttac atttctcttg   4020

gaaagtaaag tagaaaattg gaagtggaca cacacactgc aatgtagctt gccaaacatg   4080

ttactttgtt ttcttccatc tttcaccgta aatctagttt ccaaagacat cagcatttgt   4140

gcttacttcc acctcagtct accagcccca cccctaccca tggcataagt ggcatttttc   4200

ttaatttcct atttttctcc tgctctctgt caagttgttc tttgtatcct ttaatgcttt   4260

atgtgcaacc tttcattgat agtgggctga tgtttggcaa tgcttctgaa ctgtcacaga   4320

gcaggctgta gctttccaca gccactgccc atgcataagc agaacagcct ggccttttga   4380

atgtattttc ctgggttttt tccccttttc tttttttagt ttagagatgc agtaacaaaa   4440

ctgttgcaaa gcactggcat tttatgtatt caataaataa gtgatgtaca tttttaaaaa   4500

aatttaaata aatgcaatga gaagccccaa gaaag                              4535


<210>  174
<211>  759
<212>  PRT
<213>  Homo sapiens

<400>  174

Met Ile Ser Ser Thr Ser Val Tyr Gly Leu Lys Met Gln Trp Thr Pro 
1               5                   10                  15


Glu His Ala Gln Trp Pro Glu Gln His Phe Asp Ile Thr Ser Thr Thr 
            20                  25                  30


Arg Ser Pro Ala His Lys Val Glu Ala Tyr Arg Gly His Leu Gln Arg 
        35                  40                  45


Thr Tyr Gln Tyr Ala Trp Ala Asn Asp Asp Ile Ser Ala Leu Thr Ala 
    50                  55                  60


Ser Asn Leu Leu Lys Lys Tyr Ala Glu Lys Tyr Ser Gly Ile Leu Glu 
65                  70                  75                  80


Gly Pro Val Asp Arg Pro Val Leu Ser Asn Tyr Ser Asp Thr Pro Ser 
                85                  90                  95


Gly Leu Val Asn Gly Arg Lys Asn Glu Ser Glu Pro Trp Gln Pro Ser 
            100                 105                 110


Leu Asn Ser Glu Ala Val Tyr Pro Met Asn Cys Val Pro Asp Val Ile 
        115                 120                 125


Thr Ala Ser Lys Ala Gly Val Ser Ser Ala Leu Pro Pro Ala Asp Val 
    130                 135                 140


Ser Ala Ser Ile Gly Ser Ser Pro Gly Val Ala Ser Asn Leu Thr Glu 
145                 150                 155                 160


Pro Ser Tyr Ser Ser Ser Thr Cys Gly Ser His Thr Val Pro Ser Leu 
                165                 170                 175


His Ala Gly Leu Pro Ser Gln Glu Tyr Ala Pro Gly Tyr Asn Gly Ser 
            180                 185                 190


Tyr Leu His Ser Thr Tyr Ser Ser Gln Pro Ala Pro Ala Leu Pro Ser 
        195                 200                 205


Pro His Pro Ser Pro Leu His Ser Ser Gly Leu Leu Gln Pro Pro Pro 
    210                 215                 220


Pro Pro Pro Pro Pro Pro Ala Leu Val Pro Gly Tyr Asn Gly Thr Ser 
225                 230                 235                 240


Asn Leu Ser Ser Tyr Ser Tyr Pro Ser Ala Ser Tyr Pro Pro Gln Thr 
                245                 250                 255


Ala Val Gly Ser Gly Tyr Ser Pro Gly Gly Ala Pro Pro Pro Pro Ser 
            260                 265                 270


Ala Tyr Leu Pro Ser Gly Ile Pro Ala Pro Thr Pro Leu Pro Pro Thr 
        275                 280                 285


Thr Val Pro Gly Tyr Thr Tyr Gln Gly His Gly Leu Thr Pro Ile Ala 
    290                 295                 300


Pro Ser Ala Leu Thr Asn Ser Ser Ala Ser Ser Leu Lys Arg Lys Ala 
305                 310                 315                 320


Phe Tyr Met Ala Gly Gln Gly Asp Met Asp Ser Ser Tyr Gly Asn Tyr 
                325                 330                 335


Ser Tyr Gly Gln Gln Arg Ser Thr Gln Ser Pro Met Tyr Arg Met Pro 
            340                 345                 350


Asp Asn Ser Ile Ser Asn Thr Asn Arg Gly Asn Gly Phe Asp Arg Ser 
        355                 360                 365


Ala Glu Thr Ser Ser Leu Ala Phe Lys Pro Thr Lys Gln Leu Met Ser 
    370                 375                 380


Ser Glu Gln Gln Arg Lys Phe Ser Ser Gln Ser Ser Arg Ala Leu Thr 
385                 390                 395                 400


Pro Pro Ser Tyr Ser Thr Ala Lys Asn Ser Leu Gly Ser Arg Ser Ser 
                405                 410                 415


Glu Ser Phe Gly Lys Tyr Thr Ser Pro Val Met Ser Glu His Gly Asp 
            420                 425                 430


Glu His Arg Gln Leu Leu Ser His Pro Met Gln Gly Pro Gly Leu Arg 
        435                 440                 445


Ala Ala Thr Ser Ser Asn His Ser Val Asp Glu Gln Leu Lys Asn Thr 
    450                 455                 460


Asp Thr His Leu Ile Asp Leu Val Thr Asn Glu Ile Ile Thr Gln Gly 
465                 470                 475                 480


Pro Pro Val Asp Trp Asn Asp Ile Ala Gly Leu Asp Leu Val Lys Ala 
                485                 490                 495


Val Ile Lys Glu Glu Val Leu Trp Pro Val Leu Arg Ser Asp Ala Phe 
            500                 505                 510


Ser Gly Leu Thr Ala Leu Pro Arg Ser Ile Leu Leu Phe Gly Pro Arg 
        515                 520                 525


Gly Thr Gly Lys Thr Leu Leu Gly Arg Cys Ile Ala Ser Gln Leu Gly 
    530                 535                 540


Ala Thr Phe Phe Lys Ile Ala Gly Ser Gly Leu Val Ala Lys Trp Leu 
545                 550                 555                 560


Gly Glu Ala Glu Lys Ile Ile His Ala Ser Phe Leu Val Ala Arg Cys 
                565                 570                 575


Arg Gln Pro Ser Val Ile Phe Val Ser Asp Ile Asp Met Leu Leu Ser 
            580                 585                 590


Ser Gln Val Asn Glu Glu His Ser Pro Val Ser Arg Met Arg Thr Glu 
        595                 600                 605


Phe Leu Met Gln Leu Asp Thr Val Leu Thr Ser Ala Glu Asp Gln Ile 
    610                 615                 620


Val Val Ile Cys Ala Thr Ser Lys Pro Glu Glu Ile Asp Glu Ser Leu 
625                 630                 635                 640


Arg Arg Tyr Phe Met Lys Arg Leu Leu Ile Pro Leu Pro Asp Ser Thr 
                645                 650                 655


Ala Arg His Gln Ile Ile Val Gln Leu Leu Ser Gln His Asn Tyr Cys 
            660                 665                 670


Leu Asn Asp Lys Glu Phe Ala Leu Leu Val Gln Arg Thr Glu Gly Phe 
        675                 680                 685


Ser Gly Leu Asp Val Ala His Leu Cys Gln Glu Ala Val Val Gly Pro 
    690                 695                 700


Leu His Ala Met Pro Ala Thr Asp Leu Ser Ala Ile Met Pro Ser Gln 
705                 710                 715                 720


Leu Arg Pro Val Thr Tyr Gln Asp Phe Glu Asn Ala Phe Cys Lys Ile 
                725                 730                 735


Gln Pro Ser Ile Ser Gln Lys Glu Leu Asp Met Tyr Val Glu Trp Asn 
            740                 745                 750


Lys Met Phe Gly Cys Ser Gln 
        755


<210>  175
<211>  3488
<212>  DNA
<213>  Homo sapiens

<400>  175
gcaaaaccgt gagctggatt tataatcgcc ctataaagct ccagaggcgg tcaggcacct     60

gcagaggagc cccgccgctc cgccgactag ctgcccccgc gagcaacggc ctcgtgattt    120

ccccgccgat ccggtccccg cctccccact ctgcccccgc ctaccccgga gccgtgcagc    180

cgcctctccg aatctctctc ttctcctggc gctcgcgtgc gagagggaac tagcgagaac    240

gaggaagcag ctggaggtga cgccgggcag attacgcctg tcagggccga gccgagcgga    300

tcgctgggcg ctgtgcagag gaaaggcggg agtgcccggc tcgctgtcgc agagccgagc    360

ctgtttctgc gccggaccag tcgaggactc tggacagtag aggccccggg acgaccgagc    420

tgatggcgtc ttcgacccca tcttcgtccg caacctcctc gaacgcggga gcggacccca    480

ataccactaa cctgcgcccc acaacgtacg atacctggtg cggcgtggcc catggatgca    540

ccagaaaact ggggctcaag atctgcggct tcttgcaaag gaccaacagc ctggaagaga    600

agagtcgcct tgtgagtgcc ttcaaggaga ggcaatcctc caagaacctg ctttcctgtg    660

aaaacagcga ccgggatgcc cgcttccggc gcacagagac tgacttctct aatctgtttg    720

ctagagatct gcttccggct aagaacggtg aggagcaaac cgtgcaattc ctcctggaag    780

tggtggacat actcctcaac tatgtccgca agacatttga tcgctccacc aaggtgctgg    840

actttcatca cccacaccag ttgctggaag gcatggaggg cttcaacttg gagctctctg    900

accaccccga gtccctggag cagatcctgg ttgactgcag agacaccttg aagtatgggg    960

ttcgcacagg tcatcctcga tttttcaacc agctctccac tggattggat attattggcc   1020

tagctggaga atggctgaca tcaacggcca ataccaacat gtttacatat gaaattgcac   1080

cagtgtttgt cctcatggaa caaataacac ttaagaagat gagagagata gttggatggt   1140

caagtaaaga tggtgatggg atattttctc ctgggggcgc catatccaac atgtacagca   1200

tcatggctgc tcgctacaag tacttcccgg aagttaagac aaagggcatg gcggctgtgc   1260

ctaaactggt cctcttcacc tcagaacaga gtcactattc cataaagaaa gctggggctg   1320

cacttggctt tggaactgac aatgtgattt tgataaagtg caatgaaagg gggaaaataa   1380

ttccagctga ttttgaggca aaaattcttg aagccaaaca gaagggatat gttccctttt   1440

atgtcaatgc aactgctggc acgactgttt atggagcttt tgatccgata caagagattg   1500

cagatatatg tgagaaatat aacctttggt tgcatgtcga tgctgcctgg ggaggtgggc   1560

tgctcatgtc caggaagcac cgccataaac tcaacggcat agaaagggcc aactcagtca   1620

cctggaaccc tcacaagatg atgggcgtgc tgttgcagtg ctctgccatt ctcgtcaagg   1680

aaaagggtat actccaagga tgcaaccaga tgtgtgcagg atacctcttc cagccagaca   1740

agcagtatga tgtctcctac gacaccgggg acaaggcaat tcagtgtggc cgccacgtgg   1800

atatcttcaa gttctggctg atgtggaaag caaagggcac agtgggattt gaaaaccaga   1860

tcaacaaatg cctggaactg gctgaatacc tctatgccaa gattaaaaac agagaagaat   1920

ttgagatggt tttcaatggc gagcctgagc acacaaacgt ctgtttttgg tatattccac   1980

aaagcctcag gggtgtgcca gacagccctc aacgacggga aaagctacac aaggtggctc   2040

caaaaatcaa agccctgatg atggagtcag gtacgaccat ggttggctac cagccccaag   2100

gggacaaggc caacttcttc cggatggtca tctccaaccc agccgctacc cagtctgaca   2160

ttgacttcct cattgaggag atagaaagac tgggccagga tctgtaatca tccttcgcag   2220

aacatgagtt tatgggaatg ccttttccct ctggcactcc agaacaaacc tctatatgtt   2280

gctgaaacac acaggccatt tcattgaggg aaaacataat atcttgaaga atattgttaa   2340

aaccttactt aaagcttgtt tgttctagtt agcaggaaat agtgttcttt ttaaaaagtt   2400

gcacattagg aacagagtat atatgtacag ttatacatac ctctctctat atatacatgt   2460

atagtgagtg tggcttagta atagatcacg gcatgtttcc cgctccaaga gaattcactt   2520

taccttcagc agttaccgag gagctaaaca tgctgccaac cagcttgtcc aacaactcca   2580

ggaaaactgt ttttcaaaac gccatgtcct aggggccaag ggaaatgctg ttggtgagaa   2640

tcgacctcac tgtcagcgtt tctccacctg aagtgatgat ggatgagaaa aaacaccacc   2700

aaatgacaag tcacaccctc cccattagta tcctgttagg ggaaaatagt agcagagtca   2760

ttgttacagg tgtactatgg ctgtattttt agagattaat ttgtgtagat tgtgtaaatt   2820

cctgttgtct gaccttggtg gtgggagggg gagactatgt gtcatgattt caatgattgt   2880

ttaattgtag gtcaatgaaa tatttgctta tttatattca gagatgtacc atgttaaaga   2940

ggcgtcttgt attttcttcc catttgtaat gtatcttatt tatatatgaa gtaagttctg   3000

aaaactgttt atggtatttt cgtgcatttg tgagccaaag agaaaagatt aaaattagtg   3060

agatttgtat ttatattaga gtgcccttaa aataatgatt taagcatttt actgtctgta   3120

agagaattct aagattgtac ataaagtcat atatatggaa atcctgttac ttaaatagca   3180

tctgctcttc tcttacgctc tctgtctggc tgtacgtctg gtgttctcaa tgcttttcta   3240

gcaactgttg gataataact agatctcctg taattttgta gtagttgatg accaatctct   3300

gtgactcgct tagctgaaac ctaaggcaac atttccgaag accttctgaa gatctcagat   3360

aaagtgacca ggctcacaac tgtttttgaa gaagggaaat tcacactgtg cgttttagag   3420

tatgcaagaa gaatataaat aaataaaaat attctccatg gagaatttga acaaaaaaaa   3480

aaaaaaaa                                                            3488


<210>  176
<211>  594
<212>  PRT
<213>  Homo sapiens

<400>  176

Met Ala Ser Ser Thr Pro Ser Ser Ser Ala Thr Ser Ser Asn Ala Gly 
1               5                   10                  15


Ala Asp Pro Asn Thr Thr Asn Leu Arg Pro Thr Thr Tyr Asp Thr Trp 
            20                  25                  30


Cys Gly Val Ala His Gly Cys Thr Arg Lys Leu Gly Leu Lys Ile Cys 
        35                  40                  45


Gly Phe Leu Gln Arg Thr Asn Ser Leu Glu Glu Lys Ser Arg Leu Val 
    50                  55                  60


Ser Ala Phe Lys Glu Arg Gln Ser Ser Lys Asn Leu Leu Ser Cys Glu 
65                  70                  75                  80


Asn Ser Asp Arg Asp Ala Arg Phe Arg Arg Thr Glu Thr Asp Phe Ser 
                85                  90                  95


Asn Leu Phe Ala Arg Asp Leu Leu Pro Ala Lys Asn Gly Glu Glu Gln 
            100                 105                 110


Thr Val Gln Phe Leu Leu Glu Val Val Asp Ile Leu Leu Asn Tyr Val 
        115                 120                 125


Arg Lys Thr Phe Asp Arg Ser Thr Lys Val Leu Asp Phe His His Pro 
    130                 135                 140


His Gln Leu Leu Glu Gly Met Glu Gly Phe Asn Leu Glu Leu Ser Asp 
145                 150                 155                 160


His Pro Glu Ser Leu Glu Gln Ile Leu Val Asp Cys Arg Asp Thr Leu 
                165                 170                 175


Lys Tyr Gly Val Arg Thr Gly His Pro Arg Phe Phe Asn Gln Leu Ser 
            180                 185                 190


Thr Gly Leu Asp Ile Ile Gly Leu Ala Gly Glu Trp Leu Thr Ser Thr 
        195                 200                 205


Ala Asn Thr Asn Met Phe Thr Tyr Glu Ile Ala Pro Val Phe Val Leu 
    210                 215                 220


Met Glu Gln Ile Thr Leu Lys Lys Met Arg Glu Ile Val Gly Trp Ser 
225                 230                 235                 240


Ser Lys Asp Gly Asp Gly Ile Phe Ser Pro Gly Gly Ala Ile Ser Asn 
                245                 250                 255


Met Tyr Ser Ile Met Ala Ala Arg Tyr Lys Tyr Phe Pro Glu Val Lys 
            260                 265                 270


Thr Lys Gly Met Ala Ala Val Pro Lys Leu Val Leu Phe Thr Ser Glu 
        275                 280                 285


Gln Ser His Tyr Ser Ile Lys Lys Ala Gly Ala Ala Leu Gly Phe Gly 
    290                 295                 300


Thr Asp Asn Val Ile Leu Ile Lys Cys Asn Glu Arg Gly Lys Ile Ile 
305                 310                 315                 320


Pro Ala Asp Phe Glu Ala Lys Ile Leu Glu Ala Lys Gln Lys Gly Tyr 
                325                 330                 335


Val Pro Phe Tyr Val Asn Ala Thr Ala Gly Thr Thr Val Tyr Gly Ala 
            340                 345                 350


Phe Asp Pro Ile Gln Glu Ile Ala Asp Ile Cys Glu Lys Tyr Asn Leu 
        355                 360                 365


Trp Leu His Val Asp Ala Ala Trp Gly Gly Gly Leu Leu Met Ser Arg 
    370                 375                 380


Lys His Arg His Lys Leu Asn Gly Ile Glu Arg Ala Asn Ser Val Thr 
385                 390                 395                 400


Trp Asn Pro His Lys Met Met Gly Val Leu Leu Gln Cys Ser Ala Ile 
                405                 410                 415


Leu Val Lys Glu Lys Gly Ile Leu Gln Gly Cys Asn Gln Met Cys Ala 
            420                 425                 430


Gly Tyr Leu Phe Gln Pro Asp Lys Gln Tyr Asp Val Ser Tyr Asp Thr 
        435                 440                 445


Gly Asp Lys Ala Ile Gln Cys Gly Arg His Val Asp Ile Phe Lys Phe 
    450                 455                 460


Trp Leu Met Trp Lys Ala Lys Gly Thr Val Gly Phe Glu Asn Gln Ile 
465                 470                 475                 480


Asn Lys Cys Leu Glu Leu Ala Glu Tyr Leu Tyr Ala Lys Ile Lys Asn 
                485                 490                 495


Arg Glu Glu Phe Glu Met Val Phe Asn Gly Glu Pro Glu His Thr Asn 
            500                 505                 510


Val Cys Phe Trp Tyr Ile Pro Gln Ser Leu Arg Gly Val Pro Asp Ser 
        515                 520                 525


Pro Gln Arg Arg Glu Lys Leu His Lys Val Ala Pro Lys Ile Lys Ala 
    530                 535                 540


Leu Met Met Glu Ser Gly Thr Thr Met Val Gly Tyr Gln Pro Gln Gly 
545                 550                 555                 560


Asp Lys Ala Asn Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr 
                565                 570                 575


Gln Ser Asp Ile Asp Phe Leu Ile Glu Glu Ile Glu Arg Leu Gly Gln 
            580                 585                 590


Asp Leu 



<210>  177
<211>  1272
<212>  DNA
<213>  Homo sapiens

<400>  177
gcaaaaccgt gagctggatt tataatcgcc ctataaagct ccagaggcgg tcaggcacct     60

gcagaggagc cccgccgctc cgccgactag ctgcccccgc gagcaacggc ctcgtgattt    120

ccccgccgat ccggtccccg cctccccact ctgcccccgc ctaccccgga gccgtgcagc    180

cgcctctccg aatctctctc ttctcctggc gctcgcgtgc gagagggaac tagcgagaac    240

gaggaagcag ctggaggtga cgccgggcag attacgcctg tcagggccga gccgagcgga    300

tcgctgggcg ctgtgcagag gaaaggcggg agtgcccggc tcgctgtcgc agagccgagg    360

tggcctgttt ctgcgccgga ccagtcgagg actctggaca gtagaggccc cgggacgacc    420

gagctgatgg cgtcttcgac cccatcttcg tccgcaacct cctcgaacgc gggagcggac    480

cccaatacca ctaacctgcg ccccacaacg tacgatacct ggtgcggcgt ggcccatgga    540

tgcaccagaa aactggggct caagatctgc ggcttcttgc aaaggaccaa cagcctggaa    600

gagaagagtc gccttgtgag tgccttcaag gagaggcaat cctccaagaa cctgctttcc    660

tgtgaaaaca gcgaccggga tgcccgcttc cggcgcacag agactgactt ctctaatctg    720

tttgctagag atctgcttcc ggctaagaac ggtgaggagc aaaccgtgca attcctcctg    780

gaagtggtgg acatactcct caactatgtc cgcaagacat ttgatcgctc caccaaggtg    840

ctggactttc atcacccaca ccagttgctg gaaggcatgg agggcttcaa cttggagctc    900

tctgaccacc ccgagtccct ggagcagatc ctggttgact gcagagacac cttgaagtat    960

ggggttcgca caggtcatcc tcgatttttc aaccagctct ccactggatt ggatattatt   1020

ggcctagctg gagaatggct gacatcaacg gccaatacca acatgccatc agacatgagg   1080

gagtgttggt tgctacggtg atggggctca gagcagaacc aaagcatgat tgtgacctcc   1140

agaggtgatg gtaactgcac acatggtttc caagggtctt cctcctaaat ttccaggggc   1200

ctcccaagga aaatggacat attctttttg gaaataaaat acttctacca acataaaaaa   1260

aaaaaaaaaa aa                                                       1272


<210>  178
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  178

Met Ala Ser Ser Thr Pro Ser Ser Ser Ala Thr Ser Ser Asn Ala Gly 
1               5                   10                  15


Ala Asp Pro Asn Thr Thr Asn Leu Arg Pro Thr Thr Tyr Asp Thr Trp 
            20                  25                  30


Cys Gly Val Ala His Gly Cys Thr Arg Lys Leu Gly Leu Lys Ile Cys 
        35                  40                  45


Gly Phe Leu Gln Arg Thr Asn Ser Leu Glu Glu Lys Ser Arg Leu Val 
    50                  55                  60


Ser Ala Phe Lys Glu Arg Gln Ser Ser Lys Asn Leu Leu Ser Cys Glu 
65                  70                  75                  80


Asn Ser Asp Arg Asp Ala Arg Phe Arg Arg Thr Glu Thr Asp Phe Ser 
                85                  90                  95


Asn Leu Phe Ala Arg Asp Leu Leu Pro Ala Lys Asn Gly Glu Glu Gln 
            100                 105                 110


Thr Val Gln Phe Leu Leu Glu Val Val Asp Ile Leu Leu Asn Tyr Val 
        115                 120                 125


Arg Lys Thr Phe Asp Arg Ser Thr Lys Val Leu Asp Phe His His Pro 
    130                 135                 140


His Gln Leu Leu Glu Gly Met Glu Gly Phe Asn Leu Glu Leu Ser Asp 
145                 150                 155                 160


His Pro Glu Ser Leu Glu Gln Ile Leu Val Asp Cys Arg Asp Thr Leu 
                165                 170                 175


Lys Tyr Gly Val Arg Thr Gly His Pro Arg Phe Phe Asn Gln Leu Ser 
            180                 185                 190


Thr Gly Leu Asp Ile Ile Gly Leu Ala Gly Glu Trp Leu Thr Ser Thr 
        195                 200                 205


Ala Asn Thr Asn Met Pro Ser Asp Met Arg Glu Cys Trp Leu Leu Arg 
    210                 215                 220


<210>  179
<211>  3279
<212>  DNA
<213>  Homo sapiens

<400>  179
gtggagtccc cgcaggcaga gacgcggagt gggggtggcg ggtcgccgga tcgggtggga     60

agtaaaagac ccccaggagt gggtgcgggc tcactgatac ggctgtgagc ggcattggag    120

tgtgcgtggg tcttctcgct acgctcgggc ccgcaagagg ggtgtgagag cggctaggtc    180

caagcaggtg atgtttgcag acagaaaaag taaactgtca aggaattcag agcattgggt    240

acttgttatt tggaccagtt tgaagcatct ttgatttatt ggaccaactg gcaacagaaa    300

atgaaaagta gtgtggcaca gataaaacct tcttctggtc atgacagaag ggaaaacctt    360

aattcatatc agaggaactc ctctccagaa gacagatatg aagaacaaga acgatccccc    420

cgggatagag attactttga ttacagcaga tcagactatg agcattcaag aagaggacgt    480

tcttatgata gtagcatgga gtcacgaaac agggaccgag aaaaacgcag agaaagagaa    540

agagatacgg atcggaaaag gtctcggaaa tccccatctc ctgggaggag aaacccagaa    600

acatcagtaa ctcagagttc ctctgctcag gatgaacctg ctacaaagaa aaagaaagat    660

gagctggatc ctcttcttac tcgcactggt ggagcatata ttccccctgc aaagctcagg    720

atgatgcagg aacagattac agataaaaac agcttagcat accagaggat gagttgggag    780

gccctgaaga agtcaattaa tggccttatc aacaaagtca acatttccaa cataagtatt    840

attattcaag agcttcttca agaaaatata gttagaggaa gaggactgct gtccaggtct    900

gttttgcaag cacagagtgc ttctccaatc ttcacccatg tttatgcagc attagtggca    960

attatcaact caaaatttcc acaaattgga gaattaatcc tcaaaaggtt aattcttaat   1020

tttcgaaaag gctatcgaag aaatgacaag caactttgcc tgactgcttc aaaatttgtg   1080

gcgcatctta ttaaccaaaa tgtggcacac gaagtattat gcttagagat gctcactttg   1140

ctcctggaaa gaccaacaga tgatagcgtt gaagtagcta ttggttttct taaggaatgt   1200

ggcctcaaat taacacaagt gtcaccaaga ggaatcaatg ctatatttga acgccttcga   1260

aacattctgc atgagtctga aattgacaaa agagttcaat atatgattga agtgatgttt   1320

gctgtacgga aagatggatt caaggaccac cccattatcc tagaaggtct tgatttggtg   1380

gaagaagatg atcaattcac tcatatgctc cctctggagg atgactataa tccagaagat   1440

gttcttaatg ttttcaagat ggatcctaat tttatggaga atgaagagaa gtacaaagct   1500

attaagaaag aaattcttga tgagggagat actgactcga acacagacca ggatgctggg   1560

agtagtgaag aggacgagga agaagaagag gaagagggag aagaagatga agaaggacaa   1620

aaagtaacta ttcatgacaa aacagaaatt aacctggtct catttcgtcg tacaatttat   1680

cttgctattc agtcaagttt agattttgaa gaatgtgctc acaaattgct gaaaatggag   1740

tttcctgaaa gccaaacaaa agaactctgc aacatgatac ttgattgctg tgcccaacag   1800

aggacatacg aaaaattttt tggcttatta gctgggcgat tttgcatgct aaagaaagag   1860

tacatggaat cctttgaagg tatattcaaa gaacagtatg ataccatcca tcgcttggaa   1920

acaaacaagt tgcgaaatgt tgctaagatg tttgctcacc ttttatacac tgattcactt   1980

ccatggagtg ttcttgaatg tataaaactg agtgaagaaa ccactacatc atccagtaga   2040

atttttgtca aaatattttt ccaggaactg tgtgaataca tgggtcttcc taaacttaat   2100

gcaagattaa aggatgaaac tctgcagcca ttctttgaag gattattacc ccgagataat   2160

ccaagaaaca ctcggtttgc catcaacttc tttacttcta taggtcttgg aggtttaacg   2220

gatgaactgc gggagcatct caaaaataca ccaaaggtca ttgtggcgca gaaaccagat   2280

gttgagcaaa ataaatcctc cccatcctct tcctcttcag cgtcctcctc ttcagagtct   2340

gactcatccg actctgattc tgacagcagt gatagcagtt cagagtcttc cagtgaagag   2400

agcgactctt catccatcag tagtcatagc tctgcctcag ctaatgatgt aagaaagaag   2460

ggacatggga agaccagaag taaagaggta gataaattga tcagaaacca gcaaacaaat   2520

gataggaaac aaaaagaaag aagacaagaa cacgggcacc aggaaacaag gactgagaga   2580

gaaagaaggt cagaaaaaca cagagatcaa aattcaagtg gttcaaattg gagagatcct   2640

ataacaaagt acacatcaga caaagatgtt ccttctgaac gaaataacta cagtagagtt   2700

gcgaatgaca gagaccaaga aatgcatata gatttggaaa ataagcatgg tgatcccaaa   2760

aagaagagag gagagagaag aaattctttt tctgaaaatg agaagcatac acaccgaatt   2820

aaagacagtg aaaatttcag aagaaaagat agatcaaagt caaaggaaat gaatagaaag   2880

cactcaggct caagaagtga tgaagataga tatcaaaatg gtgccgagag acgatgggaa   2940

aaatctagca gatactctga acaatccaga gaatcaaaga aaaatcagga ccggcgaaga   3000

gaaaagtctc cagcaaaaca aaaataattc tacaaaatga cataaactgg acatgcctta   3060

tattcagttg aaacaaatta ttttttactt tgacgaactt tatagagaat tcttgtataa   3120

agtattggtt tgtatttgta aatttaaaaa atgttttcat tttaacatgt tttataattg   3180

atacatctca aggccctacc cataaaatta tttgaaaact ttcaccagaa agggatgtaa   3240

gtctcgctta tattttgtga ataaaatgat caaaagctc                          3279


<210>  180
<211>  908
<212>  PRT
<213>  Homo sapiens

<400>  180

Met Lys Ser Ser Val Ala Gln Ile Lys Pro Ser Ser Gly His Asp Arg 
1               5                   10                  15


Arg Glu Asn Leu Asn Ser Tyr Gln Arg Asn Ser Ser Pro Glu Asp Arg 
            20                  25                  30


Tyr Glu Glu Gln Glu Arg Ser Pro Arg Asp Arg Asp Tyr Phe Asp Tyr 
        35                  40                  45


Ser Arg Ser Asp Tyr Glu His Ser Arg Arg Gly Arg Ser Tyr Asp Ser 
    50                  55                  60


Ser Met Glu Ser Arg Asn Arg Asp Arg Glu Lys Arg Arg Glu Arg Glu 
65                  70                  75                  80


Arg Asp Thr Asp Arg Lys Arg Ser Arg Lys Ser Pro Ser Pro Gly Arg 
                85                  90                  95


Arg Asn Pro Glu Thr Ser Val Thr Gln Ser Ser Ser Ala Gln Asp Glu 
            100                 105                 110


Pro Ala Thr Lys Lys Lys Lys Asp Glu Leu Asp Pro Leu Leu Thr Arg 
        115                 120                 125


Thr Gly Gly Ala Tyr Ile Pro Pro Ala Lys Leu Arg Met Met Gln Glu 
    130                 135                 140


Gln Ile Thr Asp Lys Asn Ser Leu Ala Tyr Gln Arg Met Ser Trp Glu 
145                 150                 155                 160


Ala Leu Lys Lys Ser Ile Asn Gly Leu Ile Asn Lys Val Asn Ile Ser 
                165                 170                 175


Asn Ile Ser Ile Ile Ile Gln Glu Leu Leu Gln Glu Asn Ile Val Arg 
            180                 185                 190


Gly Arg Gly Leu Leu Ser Arg Ser Val Leu Gln Ala Gln Ser Ala Ser 
        195                 200                 205


Pro Ile Phe Thr His Val Tyr Ala Ala Leu Val Ala Ile Ile Asn Ser 
    210                 215                 220


Lys Phe Pro Gln Ile Gly Glu Leu Ile Leu Lys Arg Leu Ile Leu Asn 
225                 230                 235                 240


Phe Arg Lys Gly Tyr Arg Arg Asn Asp Lys Gln Leu Cys Leu Thr Ala 
                245                 250                 255


Ser Lys Phe Val Ala His Leu Ile Asn Gln Asn Val Ala His Glu Val 
            260                 265                 270


Leu Cys Leu Glu Met Leu Thr Leu Leu Leu Glu Arg Pro Thr Asp Asp 
        275                 280                 285


Ser Val Glu Val Ala Ile Gly Phe Leu Lys Glu Cys Gly Leu Lys Leu 
    290                 295                 300


Thr Gln Val Ser Pro Arg Gly Ile Asn Ala Ile Phe Glu Arg Leu Arg 
305                 310                 315                 320


Asn Ile Leu His Glu Ser Glu Ile Asp Lys Arg Val Gln Tyr Met Ile 
                325                 330                 335


Glu Val Met Phe Ala Val Arg Lys Asp Gly Phe Lys Asp His Pro Ile 
            340                 345                 350


Ile Leu Glu Gly Leu Asp Leu Val Glu Glu Asp Asp Gln Phe Thr His 
        355                 360                 365


Met Leu Pro Leu Glu Asp Asp Tyr Asn Pro Glu Asp Val Leu Asn Val 
    370                 375                 380


Phe Lys Met Asp Pro Asn Phe Met Glu Asn Glu Glu Lys Tyr Lys Ala 
385                 390                 395                 400


Ile Lys Lys Glu Ile Leu Asp Glu Gly Asp Thr Asp Ser Asn Thr Asp 
                405                 410                 415


Gln Asp Ala Gly Ser Ser Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu 
            420                 425                 430


Gly Glu Glu Asp Glu Glu Gly Gln Lys Val Thr Ile His Asp Lys Thr 
        435                 440                 445


Glu Ile Asn Leu Val Ser Phe Arg Arg Thr Ile Tyr Leu Ala Ile Gln 
    450                 455                 460


Ser Ser Leu Asp Phe Glu Glu Cys Ala His Lys Leu Leu Lys Met Glu 
465                 470                 475                 480


Phe Pro Glu Ser Gln Thr Lys Glu Leu Cys Asn Met Ile Leu Asp Cys 
                485                 490                 495


Cys Ala Gln Gln Arg Thr Tyr Glu Lys Phe Phe Gly Leu Leu Ala Gly 
            500                 505                 510


Arg Phe Cys Met Leu Lys Lys Glu Tyr Met Glu Ser Phe Glu Gly Ile 
        515                 520                 525


Phe Lys Glu Gln Tyr Asp Thr Ile His Arg Leu Glu Thr Asn Lys Leu 
    530                 535                 540


Arg Asn Val Ala Lys Met Phe Ala His Leu Leu Tyr Thr Asp Ser Leu 
545                 550                 555                 560


Pro Trp Ser Val Leu Glu Cys Ile Lys Leu Ser Glu Glu Thr Thr Thr 
                565                 570                 575


Ser Ser Ser Arg Ile Phe Val Lys Ile Phe Phe Gln Glu Leu Cys Glu 
            580                 585                 590


Tyr Met Gly Leu Pro Lys Leu Asn Ala Arg Leu Lys Asp Glu Thr Leu 
        595                 600                 605


Gln Pro Phe Phe Glu Gly Leu Leu Pro Arg Asp Asn Pro Arg Asn Thr 
    610                 615                 620


Arg Phe Ala Ile Asn Phe Phe Thr Ser Ile Gly Leu Gly Gly Leu Thr 
625                 630                 635                 640


Asp Glu Leu Arg Glu His Leu Lys Asn Thr Pro Lys Val Ile Val Ala 
                645                 650                 655


Gln Lys Pro Asp Val Glu Gln Asn Lys Ser Ser Pro Ser Ser Ser Ser 
            660                 665                 670


Ser Ala Ser Ser Ser Ser Glu Ser Asp Ser Ser Asp Ser Asp Ser Asp 
        675                 680                 685


Ser Ser Asp Ser Ser Ser Glu Ser Ser Ser Glu Glu Ser Asp Ser Ser 
    690                 695                 700


Ser Ile Ser Ser His Ser Ser Ala Ser Ala Asn Asp Val Arg Lys Lys 
705                 710                 715                 720


Gly His Gly Lys Thr Arg Ser Lys Glu Val Asp Lys Leu Ile Arg Asn 
                725                 730                 735


Gln Gln Thr Asn Asp Arg Lys Gln Lys Glu Arg Arg Gln Glu His Gly 
            740                 745                 750


His Gln Glu Thr Arg Thr Glu Arg Glu Arg Arg Ser Glu Lys His Arg 
        755                 760                 765


Asp Gln Asn Ser Ser Gly Ser Asn Trp Arg Asp Pro Ile Thr Lys Tyr 
    770                 775                 780


Thr Ser Asp Lys Asp Val Pro Ser Glu Arg Asn Asn Tyr Ser Arg Val 
785                 790                 795                 800


Ala Asn Asp Arg Asp Gln Glu Met His Ile Asp Leu Glu Asn Lys His 
                805                 810                 815


Gly Asp Pro Lys Lys Lys Arg Gly Glu Arg Arg Asn Ser Phe Ser Glu 
            820                 825                 830


Asn Glu Lys His Thr His Arg Ile Lys Asp Ser Glu Asn Phe Arg Arg 
        835                 840                 845


Lys Asp Arg Ser Lys Ser Lys Glu Met Asn Arg Lys His Ser Gly Ser 
    850                 855                 860


Arg Ser Asp Glu Asp Arg Tyr Gln Asn Gly Ala Glu Arg Arg Trp Glu 
865                 870                 875                 880


Lys Ser Ser Arg Tyr Ser Glu Gln Ser Arg Glu Ser Lys Lys Asn Gln 
                885                 890                 895


Asp Arg Arg Arg Glu Lys Ser Pro Ala Lys Gln Lys 
            900                 905


<210>  181
<211>  6082
<212>  DNA
<213>  Homo sapiens

<400>  181
ataacgtctt tgtcactaaa atgttcccca ggggccttcg gcgagtcttt ttgtttggtt     60

ttttgttttt aatctgtggc tcttgataat ttatctagtg gttgcctaca cctgaaaaac    120

aagacacagt gtttaactat caacgaaaga actggacggc tccccgccgc agtcccactc    180

cccgagtttg tggctggcat ttgggccacg ccgggctggg cggtcacagc gaggggcgcg    240

cagtttgggg tcacacagct ccgcttctag gccccaacca ccgttaaaag gggaagcccg    300

tgccccatca ggtccgctct tgctgagccc agagccatcc cgcgctctgc gggctgggag    360

gcccgggcca ggacgcgagt cctgcgcagc cgaggttccc cagcgccccc tgcagccgcg    420

cgtaggcaga gacggagccc ggccctgcgc ctccgcacca cgcccgggac cccacccagc    480

ggcccgtacc cggagaagca gcgcgagcac ccgaagctcc cggctggcgg cagaaaccgg    540

gagtggggcc gggcgagtgc gcggcatccc aggccggccc gaacgctccg cccgcggtgg    600

gccgacttcc cctcctcttc cctctctcct tcctttagcc cgctggcgcc ggacacgctg    660

cgcctcatct cttggggcgt tcttccccgt tggccaaccg tcgcatcccg tgcaactttg    720

gggtagtggc cgtttagtgt tgaatgttcc ccaccgagag cgcatggctt gggaagcgag    780

gcgcgaaccc ggcccccgaa gggccgccgt ccgggagacg gtgatgctgt tgctgtgcct    840

gggggtcccg accggccgcc cctacaacgt ggacactgag agcgcgctgc tttaccaggg    900

cccccacaac acgctgttcg gctactcggt cgtgctgcac agccacgggg cgaaccgatg    960

gctcctagtg ggtgcgccca ctgccaactg gctcgccaac gcttcagtga tcaatcccgg   1020

ggcgatttac agatgcagga tcggaaagaa tcccggccag acgtgcgaac agctccagct   1080

gggtagccct aatggagaac cttgtggaaa gacttgtttg gaagagagag acaatcagtg   1140

gttgggggtc acactttcca gacagccagg agaaaatgga tccatcgtga cttgtgggca   1200

tagatggaaa aatatatttt acataaagaa tgaaaataag ctccccactg gtggttgcta   1260

tggagtgccc cctgatttac gaacagaact gagtaaaaga atagctccgt gttatcaaga   1320

ttatgtgaaa aaatttggag aaaattttgc atcatgtcaa gctggaatat ccagttttta   1380

cacaaaggat ttaattgtga tgggggcccc aggatcatct tactggactg gctctctttt   1440

tgtctacaat ataactacaa ataaatacaa ggctttttta gacaaacaaa atcaagtaaa   1500

atttggaagt tatttaggat attcagtcgg agctggtcat tttcggagcc agcatactac   1560

cgaagtagtc ggaggagctc ctcaacatga gcagattggt aaggcatata tattcagcat   1620

tgatgaaaaa gaactaaata tcttacatga aatgaaaggt aaaaagcttg gatcgtactt   1680

tggagcttct gtctgtgctg tggacctcaa tgcagatggc ttctcagatc tgctcgtggg   1740

agcacccatg cagagcacca tcagagagga aggaagagtg tttgtgtaca tcaactctgg   1800

ctcgggagca gtaatgaatg caatggaaac aaacctcgtt ggaagtgaca aatatgctgc   1860

aagatttggg gaatctatag ttaatcttgg cgacattgac aatgatggct ttgaagatgt   1920

tgctatcgga gctccacaag aagatgactt gcaaggtgct atttatattt acaatggccg   1980

tgcagatggg atctcgtcaa ccttctcaca gagaattgaa ggacttcaga tcagcaaatc   2040

gttaagtatg tttggacagt ctatatcagg acaaattgat gcagataata atggctatgt   2100

agatgtagca gttggtgctt ttcggtctga ttctgctgtc ttgctaagga caagacctgt   2160

agtaattgtt gacgcttctt taagccaccc tgagtcagta aatagaacga aatttgactg   2220

tgttgaaaat ggatggcctt ctgtgtgcat agatctaaca ctttgtttct catataaggg   2280

caaggaagtt ccaggttaca ttgttttgtt ttataacatg agtttggatg tgaacagaaa   2340

ggcagagtct ccaccaagat tctatttctc ttctaatgga acttctgacg tgattacagg   2400

aagcatacag gtgtccagca gagaagctaa ctgtagaaca catcaagcat ttatgcggaa   2460

agatgtgcgg gacatcctca ccccaattca gattgaagct gcttaccacc ttggtcctca   2520

tgtcatcagt aaacgaagta cagaggaatt cccaccactt cagccaattc ttcagcagaa   2580

gaaagaaaaa gacataatga aaaaaacaat aaactttgca aggttttgtg cccatgaaaa   2640

ttgttctgct gatttacagg tttctgcaaa gattgggttt ttgaagcccc atgaaaataa   2700

aacatatctt gctgttggga gtatgaagac attgatgttg aatgtgtcct tgtttaatgc   2760

tggagatgat gcatatgaaa cgactctaca tgtcaaacta cccgtgggtc tttatttcat   2820

taagatttta gagctggaag agaagcaaat aaactgtgaa gtcacagata actctggcgt   2880

ggtacaactt gactgcagta ttggctatat atatgtagat catctctcaa ggatagatat   2940

tagctttctc ctggatgtga gctcactcag cagagcggaa gaggacctca gtatcacagt   3000

gcatgctacc tgtgaaaatg aagaggaaat ggacaatcta aagcacagca gagtgactgt   3060

agcaatacct ttaaaatatg aggttaagct gactgttcat gggtttgtaa acccaacttc   3120

atttgtgtat ggatcaaatg atgaaaatga gcctgaaacg tgcatggtgg agaaaatgaa   3180

cttaactttc catgttatca acactggcaa tagtatggct cccaatgtta gtgtggaaat   3240

aatggtacca aattctttta gcccccaaac tgataagctg ttcaacattt tggatgtcca   3300

gactactact ggagaatgcc actttgaaaa ttatcaaaga gtgtgtgcat tagagcagca   3360

aaagagtgca atgcagacct tgaaaggcat agtccggttc ttgtccaaga ctgataagag   3420

gctattgtac tgcataaaag ctgatccaca ttgtttaaat ttcttgtgta attttgggaa   3480

aatggaaagt ggaaaagaag ccagtgttca tatccaactg gaaggccggc catccatttt   3540

agaaatggat gagacttcag cactcaagtt tgaaataaga gcaacaggtt ttccagagcc   3600

aaatccaaga gtaattgaac taaacaagga tgagaatgtt gcgcatgttc tactggaagg   3660

actacatcat caaagaccca aacgttattt caccatagtg attatttcaa gtagcttgct   3720

acttggactt attgtacttc tgttgatctc atatgttatg tggaaggctg gcttctttaa   3780

aagacaatac aaatctatcc tacaagaaga aaacagaaga gacagttgga gttatatcaa   3840

cagtaaaagc aatgatgatt aaggacttct ttcaaattga gagaatggaa aacagactca   3900

ggttgtagta aagaaattta aaagacactg tttacaagaa aaaatgaatt ttgtttggac   3960

ttcttttact catgatcttg tgacatatta tgtcttcatg caaggggaaa atctcagcaa   4020

tgattactct ttgagataga agaactgcaa aggtaataat acagccaaag ataatctctc   4080

agcttttaaa tgggtagaga aacactaaag cattcaattt attcaagaaa agtaagccct   4140

tgaagatatc ttgaaatgaa agtataactg agttaaatta tactggagaa gtcttagact   4200

tgaaatacta cttaccatat gtgcttgcct cagtaaaatg aaccccactg ggtgggcaga   4260

ggttcatttc aaatacatct ttgatacttg ttcaaaatat gttctttaaa aatataattt   4320

tttagagagc tgttcccaaa ttttctaacg agtggaccat tatcacttta aagcccttta   4380

tttataatac atttcctacg ggctgtgttc caacaaccat tttttttcag cagactatga   4440

atattatagt attataggcc aaactggcaa acttcagact gaacatgtac actggtttga   4500

gcttagtgaa attacttctg gataattatt tttttataat tatggatttc accatctttc   4560

tttctgtata tatacatgtg tttttatgta ggtatatatt taccattctt cctatctatt   4620

cttcctataa cacaccttta tcaagcatac ccaggagtaa tcttcaaatc ttttgttata   4680

ttctgaaaca aaagattgtg agtgttgcac tttacctgat acacgctgat ttagaaaata   4740

cagaaaccat acctcactaa taactttaaa atcaaagctg tgcaaagact agggggccta   4800

tacttcatat gtattatgta ctatgtaaaa tattgactat cacacaacta tttccttgga   4860

tgtaattctt tgttaccctt tacaagtata agtgttacct tacatggaaa cgaagaaaca   4920

aaattcataa atttaaattc ataaatttag ctgaaagata ctgattcaat ttgtatacag   4980

tgaatataaa tgagacgaca gcaaaatttt catgaaatgt aaaatatttt tatagtttgt   5040

tcatactata tgaggttcta ttttaaatga ctttctggat tttaaaaaat ttctttaaat   5100

acaatcattt ttgtaatatt tattttatgc ttatgatcta gataattgca gaatatcatt   5160

ttatctgact ctgccttcat aagagagctg tggccgaatt ttgaacatct gttataggga   5220

gtgatcaaat tagaaggcaa tgtggaaaaa caattctggg aaagatttct ttatatgaag   5280

tccctgccac tagccagcca tcctaattga tgaaagttat ctgttcacag gcctgcagtg   5340

atggtgagga atgttctgag atttgcgaag gcatttgagt agtgaaatgt aagcacaaaa   5400

cctcctgaac ccagagtgtg tatacacagg aataaacttt atgacattta tgtattttta   5460

aaaaactttg tatcgttata aaaaggctag tcattctttc aggagaacat ctaggatcat   5520

agatgaaaaa tcaagccccg atttagaact gtcttctcca ggatggtctc taaggaaatt   5580

tacatttggt tctttcctac tcagaactac tcagaaacaa ctatatattt caggttatct   5640

gagcacagtg aaagcagagt actatggttg tccaacacag gcctctcaga tacaagggga   5700

acacaattac atattgggct agattttgcc cagttcaaaa tagtatttgt tatcaactta   5760

ctttgttact tgtatcatga attttaaaac cctaccactt taagaagaca gggatgggtt   5820

attctttttt ggcaggtagg ctatataact atgtgatttt gaaatttaac tgctctggat   5880

tagggagcag tgaatcaagg cagacttatg aaatctgtat tatatttgta acagaatata   5940

ggaaatttaa cataattgat gagctcaaat cctgaaaaat gaaagaatcc aaattatttc   6000

agaattatct aggttaaata ttgatgtatt atgatggttg caaagttttt ttgtgtgtcc   6060

aataaacaca ttgtaaaaaa aa                                            6082


<210>  182
<211>  1032
<212>  PRT
<213>  Homo sapiens

<400>  182

Met Ala Trp Glu Ala Arg Arg Glu Pro Gly Pro Arg Arg Ala Ala Val 
1               5                   10                  15


Arg Glu Thr Val Met Leu Leu Leu Cys Leu Gly Val Pro Thr Gly Arg 
            20                  25                  30


Pro Tyr Asn Val Asp Thr Glu Ser Ala Leu Leu Tyr Gln Gly Pro His 
        35                  40                  45


Asn Thr Leu Phe Gly Tyr Ser Val Val Leu His Ser His Gly Ala Asn 
    50                  55                  60


Arg Trp Leu Leu Val Gly Ala Pro Thr Ala Asn Trp Leu Ala Asn Ala 
65                  70                  75                  80


Ser Val Ile Asn Pro Gly Ala Ile Tyr Arg Cys Arg Ile Gly Lys Asn 
                85                  90                  95


Pro Gly Gln Thr Cys Glu Gln Leu Gln Leu Gly Ser Pro Asn Gly Glu 
            100                 105                 110


Pro Cys Gly Lys Thr Cys Leu Glu Glu Arg Asp Asn Gln Trp Leu Gly 
        115                 120                 125


Val Thr Leu Ser Arg Gln Pro Gly Glu Asn Gly Ser Ile Val Thr Cys 
    130                 135                 140


Gly His Arg Trp Lys Asn Ile Phe Tyr Ile Lys Asn Glu Asn Lys Leu 
145                 150                 155                 160


Pro Thr Gly Gly Cys Tyr Gly Val Pro Pro Asp Leu Arg Thr Glu Leu 
                165                 170                 175


Ser Lys Arg Ile Ala Pro Cys Tyr Gln Asp Tyr Val Lys Lys Phe Gly 
            180                 185                 190


Glu Asn Phe Ala Ser Cys Gln Ala Gly Ile Ser Ser Phe Tyr Thr Lys 
        195                 200                 205


Asp Leu Ile Val Met Gly Ala Pro Gly Ser Ser Tyr Trp Thr Gly Ser 
    210                 215                 220


Leu Phe Val Tyr Asn Ile Thr Thr Asn Lys Tyr Lys Ala Phe Leu Asp 
225                 230                 235                 240


Lys Gln Asn Gln Val Lys Phe Gly Ser Tyr Leu Gly Tyr Ser Val Gly 
                245                 250                 255


Ala Gly His Phe Arg Ser Gln His Thr Thr Glu Val Val Gly Gly Ala 
            260                 265                 270


Pro Gln His Glu Gln Ile Gly Lys Ala Tyr Ile Phe Ser Ile Asp Glu 
        275                 280                 285


Lys Glu Leu Asn Ile Leu His Glu Met Lys Gly Lys Lys Leu Gly Ser 
    290                 295                 300


Tyr Phe Gly Ala Ser Val Cys Ala Val Asp Leu Asn Ala Asp Gly Phe 
305                 310                 315                 320


Ser Asp Leu Leu Val Gly Ala Pro Met Gln Ser Thr Ile Arg Glu Glu 
                325                 330                 335


Gly Arg Val Phe Val Tyr Ile Asn Ser Gly Ser Gly Ala Val Met Asn 
            340                 345                 350


Ala Met Glu Thr Asn Leu Val Gly Ser Asp Lys Tyr Ala Ala Arg Phe 
        355                 360                 365


Gly Glu Ser Ile Val Asn Leu Gly Asp Ile Asp Asn Asp Gly Phe Glu 
    370                 375                 380


Asp Val Ala Ile Gly Ala Pro Gln Glu Asp Asp Leu Gln Gly Ala Ile 
385                 390                 395                 400


Tyr Ile Tyr Asn Gly Arg Ala Asp Gly Ile Ser Ser Thr Phe Ser Gln 
                405                 410                 415


Arg Ile Glu Gly Leu Gln Ile Ser Lys Ser Leu Ser Met Phe Gly Gln 
            420                 425                 430


Ser Ile Ser Gly Gln Ile Asp Ala Asp Asn Asn Gly Tyr Val Asp Val 
        435                 440                 445


Ala Val Gly Ala Phe Arg Ser Asp Ser Ala Val Leu Leu Arg Thr Arg 
    450                 455                 460


Pro Val Val Ile Val Asp Ala Ser Leu Ser His Pro Glu Ser Val Asn 
465                 470                 475                 480


Arg Thr Lys Phe Asp Cys Val Glu Asn Gly Trp Pro Ser Val Cys Ile 
                485                 490                 495


Asp Leu Thr Leu Cys Phe Ser Tyr Lys Gly Lys Glu Val Pro Gly Tyr 
            500                 505                 510


Ile Val Leu Phe Tyr Asn Met Ser Leu Asp Val Asn Arg Lys Ala Glu 
        515                 520                 525


Ser Pro Pro Arg Phe Tyr Phe Ser Ser Asn Gly Thr Ser Asp Val Ile 
    530                 535                 540


Thr Gly Ser Ile Gln Val Ser Ser Arg Glu Ala Asn Cys Arg Thr His 
545                 550                 555                 560


Gln Ala Phe Met Arg Lys Asp Val Arg Asp Ile Leu Thr Pro Ile Gln 
                565                 570                 575


Ile Glu Ala Ala Tyr His Leu Gly Pro His Val Ile Ser Lys Arg Ser 
            580                 585                 590


Thr Glu Glu Phe Pro Pro Leu Gln Pro Ile Leu Gln Gln Lys Lys Glu 
        595                 600                 605


Lys Asp Ile Met Lys Lys Thr Ile Asn Phe Ala Arg Phe Cys Ala His 
    610                 615                 620


Glu Asn Cys Ser Ala Asp Leu Gln Val Ser Ala Lys Ile Gly Phe Leu 
625                 630                 635                 640


Lys Pro His Glu Asn Lys Thr Tyr Leu Ala Val Gly Ser Met Lys Thr 
                645                 650                 655


Leu Met Leu Asn Val Ser Leu Phe Asn Ala Gly Asp Asp Ala Tyr Glu 
            660                 665                 670


Thr Thr Leu His Val Lys Leu Pro Val Gly Leu Tyr Phe Ile Lys Ile 
        675                 680                 685


Leu Glu Leu Glu Glu Lys Gln Ile Asn Cys Glu Val Thr Asp Asn Ser 
    690                 695                 700


Gly Val Val Gln Leu Asp Cys Ser Ile Gly Tyr Ile Tyr Val Asp His 
705                 710                 715                 720


Leu Ser Arg Ile Asp Ile Ser Phe Leu Leu Asp Val Ser Ser Leu Ser 
                725                 730                 735


Arg Ala Glu Glu Asp Leu Ser Ile Thr Val His Ala Thr Cys Glu Asn 
            740                 745                 750


Glu Glu Glu Met Asp Asn Leu Lys His Ser Arg Val Thr Val Ala Ile 
        755                 760                 765


Pro Leu Lys Tyr Glu Val Lys Leu Thr Val His Gly Phe Val Asn Pro 
    770                 775                 780


Thr Ser Phe Val Tyr Gly Ser Asn Asp Glu Asn Glu Pro Glu Thr Cys 
785                 790                 795                 800


Met Val Glu Lys Met Asn Leu Thr Phe His Val Ile Asn Thr Gly Asn 
                805                 810                 815


Ser Met Ala Pro Asn Val Ser Val Glu Ile Met Val Pro Asn Ser Phe 
            820                 825                 830


Ser Pro Gln Thr Asp Lys Leu Phe Asn Ile Leu Asp Val Gln Thr Thr 
        835                 840                 845


Thr Gly Glu Cys His Phe Glu Asn Tyr Gln Arg Val Cys Ala Leu Glu 
    850                 855                 860


Gln Gln Lys Ser Ala Met Gln Thr Leu Lys Gly Ile Val Arg Phe Leu 
865                 870                 875                 880


Ser Lys Thr Asp Lys Arg Leu Leu Tyr Cys Ile Lys Ala Asp Pro His 
                885                 890                 895


Cys Leu Asn Phe Leu Cys Asn Phe Gly Lys Met Glu Ser Gly Lys Glu 
            900                 905                 910


Ala Ser Val His Ile Gln Leu Glu Gly Arg Pro Ser Ile Leu Glu Met 
        915                 920                 925


Asp Glu Thr Ser Ala Leu Lys Phe Glu Ile Arg Ala Thr Gly Phe Pro 
    930                 935                 940


Glu Pro Asn Pro Arg Val Ile Glu Leu Asn Lys Asp Glu Asn Val Ala 
945                 950                 955                 960


His Val Leu Leu Glu Gly Leu His His Gln Arg Pro Lys Arg Tyr Phe 
                965                 970                 975


Thr Ile Val Ile Ile Ser Ser Ser Leu Leu Leu Gly Leu Ile Val Leu 
            980                 985                 990


Leu Leu Ile Ser Tyr Val Met Trp Lys Ala Gly Phe Phe Lys Arg Gln 
        995                 1000                1005


Tyr Lys Ser Ile Leu Gln Glu Glu Asn Arg Arg Asp Ser Trp Ser Tyr 
    1010                1015                1020


Ile Asn Ser Lys Ser Asn Asp Asp 
1025                1030


<210>  183
<211>  1677
<212>  DNA
<213>  Homo sapiens

<400>  183
atgccctgga ggaggcgcag gaaccgggtg agtgccctgg agggcggccg ggaggaagag     60

gcgcccccgg aggctgccgc tgtgcctccg gcgctgttaa cgtccccgca gcagacggag    120

gcggcggccg agcggattct gctccggggc atcttcgaga tcgggaggga cagttgtgac    180

gtggtgctga gcgagcgagc actgcggtgg cggcccattc agcccgagcg cccggcgggt    240

gattctaagt atgacttgct atgtaaagaa gaatttattg aactcaaaga catattctct    300

gtgaaactga aacggcgttg ttctgttaaa cagcagagaa gtggtacttt attaggtatc    360

acactcttca tctgcttgaa aaaggaacaa aataaactaa agaattctac acttgatctt    420

attaatttaa gtgaagacca ctgtgacata tggtttagac agttcaagaa aatattggca    480

ggctttccaa acagaccgaa gtcattaaaa atactcctta acccccaaag tcacaaaaaa    540

gaagctaccc aggtttatta tgagaaggtt gaacctctgt tgaagcttgc aggaataaaa    600

actgatgtaa caataatgga atatgaaggg cacgctctgt cactgcttaa ggaatgtgaa    660

ctccagggat ttgatggtgg gcatcggaaa ccattgttcg caatacattg gagtgtacag    720

agattgttca ctggcatgca aacgttagaa ccaagtgttg tctgtgttgg tggagatgga    780

tctgctagcg aagtagccca tgctttgctt ctgagagctc agaagaatgc tgggatggaa    840

acagaccgaa tcctgactcc tgtcagagca cagcttccac ttggcttaat accagcagga    900

tctaccaatg tattggcaca ttctcttcat ggagttcctc atgtgataac tgcaacattg    960

cacattataa tggggcatgt acagctggtc gacgtctgca ccttcagcac cgctggcaag   1020

cttcttcgct ttgggttctc agccatgttt ggctttggtg gaagaacttt ggctctggca   1080

gaaaaatatc gatggatgtc ccctaaccaa cggagagatt ttgctgttgt taaggcactg   1140

gcaaaactta aggcagaaga ctgtgaaata tcatttttac catttaacag ctctgatgat   1200

gtgcaagaaa ggagggcaca gggatctccc aaatctgact gtaatgatca atggcaaatg   1260

atccagggtc agttcttgaa tgtcagcatt atggcaattc cttgcctgtg ttcagtggca   1320

cctagaggct tggcacctaa taccagatta aataatggaa gtatggctct tataattgcc   1380

cgaaacactt ctcggccaga atttataaaa cacctgaaaa gatatgccag tgtaaaaaat   1440

cagttcaatt ttccatttgt tgagacttac actgttgagg aagtaaaagt tcatccaagg   1500

aataatactg gtggatataa tccagaggag gaggaggatg aaactgcttc agaaaattgt   1560

ttcccttgga atgtagatgg tgacttaatg gaagttgcat cagaggtcca tattagattg   1620

catccaagac ttatcagtct ttatggagga agcatggaag aaatgattcc aaagtaa      1677


<210>  184
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  184

Met Pro Trp Arg Arg Arg Arg Asn Arg Val Ser Ala Leu Glu Gly Gly 
1               5                   10                  15


Arg Glu Glu Glu Ala Pro Pro Glu Ala Ala Ala Val Pro Pro Ala Leu 
            20                  25                  30


Leu Thr Ser Pro Gln Gln Thr Glu Ala Ala Ala Glu Arg Ile Leu Leu 
        35                  40                  45


Arg Gly Ile Phe Glu Ile Gly Arg Asp Ser Cys Asp Val Val Leu Ser 
    50                  55                  60


Glu Arg Ala Leu Arg Trp Arg Pro Ile Gln Pro Glu Arg Pro Ala Gly 
65                  70                  75                  80


Asp Ser Lys Tyr Asp Leu Leu Cys Lys Glu Glu Phe Ile Glu Leu Lys 
                85                  90                  95


Asp Ile Phe Ser Val Lys Leu Lys Arg Arg Cys Ser Val Lys Gln Gln 
            100                 105                 110


Arg Ser Gly Thr Leu Leu Gly Ile Thr Leu Phe Ile Cys Leu Lys Lys 
        115                 120                 125


Glu Gln Asn Lys Leu Lys Asn Ser Thr Leu Asp Leu Ile Asn Leu Ser 
    130                 135                 140


Glu Asp His Cys Asp Ile Trp Phe Arg Gln Phe Lys Lys Ile Leu Ala 
145                 150                 155                 160


Gly Phe Pro Asn Arg Pro Lys Ser Leu Lys Ile Leu Leu Asn Pro Gln 
                165                 170                 175


Ser His Lys Lys Glu Ala Thr Gln Val Tyr Tyr Glu Lys Val Glu Pro 
            180                 185                 190


Leu Leu Lys Leu Ala Gly Ile Lys Thr Asp Val Thr Ile Met Glu Tyr 
        195                 200                 205


Glu Gly His Ala Leu Ser Leu Leu Lys Glu Cys Glu Leu Gln Gly Phe 
    210                 215                 220


Asp Gly Gly His Arg Lys Pro Leu Phe Ala Ile His Trp Ser Val Gln 
225                 230                 235                 240


Arg Leu Phe Thr Gly Met Gln Thr Leu Glu Pro Ser Val Val Cys Val 
                245                 250                 255


Gly Gly Asp Gly Ser Ala Ser Glu Val Ala His Ala Leu Leu Leu Arg 
            260                 265                 270


Ala Gln Lys Asn Ala Gly Met Glu Thr Asp Arg Ile Leu Thr Pro Val 
        275                 280                 285


Arg Ala Gln Leu Pro Leu Gly Leu Ile Pro Ala Gly Ser Thr Asn Val 
    290                 295                 300


Leu Ala His Ser Leu His Gly Val Pro His Val Ile Thr Ala Thr Leu 
305                 310                 315                 320


His Ile Ile Met Gly His Val Gln Leu Val Asp Val Cys Thr Phe Ser 
                325                 330                 335


Thr Ala Gly Lys Leu Leu Arg Phe Gly Phe Ser Ala Met Phe Gly Phe 
            340                 345                 350


Gly Gly Arg Thr Leu Ala Leu Ala Glu Lys Tyr Arg Trp Met Ser Pro 
        355                 360                 365


Asn Gln Arg Arg Asp Phe Ala Val Val Lys Ala Leu Ala Lys Leu Lys 
    370                 375                 380


Ala Glu Asp Cys Glu Ile Ser Phe Leu Pro Phe Asn Ser Ser Asp Asp 
385                 390                 395                 400


Val Gln Glu Arg Arg Ala Gln Gly Ser Pro Lys Ser Asp Cys Asn Asp 
                405                 410                 415


Gln Trp Gln Met Ile Gln Gly Gln Phe Leu Asn Val Ser Ile Met Ala 
            420                 425                 430


Ile Pro Cys Leu Cys Ser Val Ala Pro Arg Gly Leu Ala Pro Asn Thr 
        435                 440                 445


Arg Leu Asn Asn Gly Ser Met Ala Leu Ile Ile Ala Arg Asn Thr Ser 
    450                 455                 460


Arg Pro Glu Phe Ile Lys His Leu Lys Arg Tyr Ala Ser Val Lys Asn 
465                 470                 475                 480


Gln Phe Asn Phe Pro Phe Val Glu Thr Tyr Thr Val Glu Glu Val Lys 
                485                 490                 495


Val His Pro Arg Asn Asn Thr Gly Gly Tyr Asn Pro Glu Glu Glu Glu 
            500                 505                 510


Asp Glu Thr Ala Ser Glu Asn Cys Phe Pro Trp Asn Val Asp Gly Asp 
        515                 520                 525


Leu Met Glu Val Ala Ser Glu Val His Ile Arg Leu His Pro Arg Leu 
    530                 535                 540


Ile Ser Leu Tyr Gly Gly Ser Met Glu Glu Met Ile Pro Lys 
545                 550                 555


<210>  185
<211>  1260
<212>  DNA
<213>  Homo sapiens

<400>  185
atgccctgga ggaggcgcag gaaccgggtg agtgccctgg agggcggccg ggaggaagag     60

gcgcccccgg aggctgccgc tgtgcctccg gcgctgttaa cgtccccgca gcagacggag    120

gcggcggccg agcggattct gctccggggc atcttcgaga tcgggaggga cagttgtgac    180

gtggtgctga gcgagcgagc actgcggtgg cggcccattc agcccgagcg cccggcgggt    240

gattctaagt atgacttgct atgtaaagaa gaatttattg aactcaaaga catattctct    300

gtgaaactga aacggcgttg ttctgttaaa cagcagagaa gtggtacttt attaggtatc    360

acactcttca tctgcttgaa aaaggaacaa aataaactaa agaattctac acttgatctt    420

attaatttaa gtgaagacca ctgtgacata tggtttagac agttcaagaa aatattggca    480

ggatctacca atgtattggc acattctctt catggagttc ctcatgtgat aactgcaaca    540

ttgcacatta taatggggca tgtacagctg gtcgacgtct gcaccttcag caccgctggc    600

aagcttcttc gctttgggtt ctcagccatg tttggctttg gtggaagaac tttggctctg    660

gcagaaaaat atcgatggat gtcccctaac caacggagag attttgctgt tgttaaggca    720

ctggcaaaac ttaaggcaga agactgtgaa atatcatttt taccatttaa cagctctgat    780

gatgtgcaag aaaggagggc acagggatct cccaaatctg actgtaatga tcaatggcaa    840

atgatccagg gtcagttctt gaatgtcagc attatggcaa ttccttgcct gtgttcagtg    900

gcacctagag gcttggcacc taataccaga ttaaataatg gaagtatggc tcttataatt    960

gcccgaaaca cttctcggcc agaatttata aaacacctga aaagatatgc cagtgtaaaa   1020

aatcagttca attttccatt tgttgagact tacactgttg aggaagtaaa agttcatcca   1080

aggaataata ctggtggata taatccagag gaggaggagg atgaaactgc ttcagaaaat   1140

tgtttccctt ggaatgtaga tggtgactta atggaagttg catcagaggt ccatattaga   1200

ttgcatccaa gacttatcag tctttatgga ggaagcatgg aagaaatgat tccaaagtaa   1260


<210>  186
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  186

Met Pro Trp Arg Arg Arg Arg Asn Arg Val Ser Ala Leu Glu Gly Gly 
1               5                   10                  15


Arg Glu Glu Glu Ala Pro Pro Glu Ala Ala Ala Val Pro Pro Ala Leu 
            20                  25                  30


Leu Thr Ser Pro Gln Gln Thr Glu Ala Ala Ala Glu Arg Ile Leu Leu 
        35                  40                  45


Arg Gly Ile Phe Glu Ile Gly Arg Asp Ser Cys Asp Val Val Leu Ser 
    50                  55                  60


Glu Arg Ala Leu Arg Trp Arg Pro Ile Gln Pro Glu Arg Pro Ala Gly 
65                  70                  75                  80


Asp Ser Lys Tyr Asp Leu Leu Cys Lys Glu Glu Phe Ile Glu Leu Lys 
                85                  90                  95


Asp Ile Phe Ser Val Lys Leu Lys Arg Arg Cys Ser Val Lys Gln Gln 
            100                 105                 110


Arg Ser Gly Thr Leu Leu Gly Ile Thr Leu Phe Ile Cys Leu Lys Lys 
        115                 120                 125


Glu Gln Asn Lys Leu Lys Asn Ser Thr Leu Asp Leu Ile Asn Leu Ser 
    130                 135                 140


Glu Asp His Cys Asp Ile Trp Phe Arg Gln Phe Lys Lys Ile Leu Ala 
145                 150                 155                 160


Gly Ser Thr Asn Val Leu Ala His Ser Leu His Gly Val Pro His Val 
                165                 170                 175


Ile Thr Ala Thr Leu His Ile Ile Met Gly His Val Gln Leu Val Asp 
            180                 185                 190


Val Cys Thr Phe Ser Thr Ala Gly Lys Leu Leu Arg Phe Gly Phe Ser 
        195                 200                 205


Ala Met Phe Gly Phe Gly Gly Arg Thr Leu Ala Leu Ala Glu Lys Tyr 
    210                 215                 220


Arg Trp Met Ser Pro Asn Gln Arg Arg Asp Phe Ala Val Val Lys Ala 
225                 230                 235                 240


Leu Ala Lys Leu Lys Ala Glu Asp Cys Glu Ile Ser Phe Leu Pro Phe 
                245                 250                 255


Asn Ser Ser Asp Asp Val Gln Glu Arg Arg Ala Gln Gly Ser Pro Lys 
            260                 265                 270


Ser Asp Cys Asn Asp Gln Trp Gln Met Ile Gln Gly Gln Phe Leu Asn 
        275                 280                 285


Val Ser Ile Met Ala Ile Pro Cys Leu Cys Ser Val Ala Pro Arg Gly 
    290                 295                 300


Leu Ala Pro Asn Thr Arg Leu Asn Asn Gly Ser Met Ala Leu Ile Ile 
305                 310                 315                 320


Ala Arg Asn Thr Ser Arg Pro Glu Phe Ile Lys His Leu Lys Arg Tyr 
                325                 330                 335


Ala Ser Val Lys Asn Gln Phe Asn Phe Pro Phe Val Glu Thr Tyr Thr 
            340                 345                 350


Val Glu Glu Val Lys Val His Pro Arg Asn Asn Thr Gly Gly Tyr Asn 
        355                 360                 365


Pro Glu Glu Glu Glu Asp Glu Thr Ala Ser Glu Asn Cys Phe Pro Trp 
    370                 375                 380


Asn Val Asp Gly Asp Leu Met Glu Val Ala Ser Glu Val His Ile Arg 
385                 390                 395                 400


Leu His Pro Arg Leu Ile Ser Leu Tyr Gly Gly Ser Met Glu Glu Met 
                405                 410                 415


Ile Pro Lys 



<210>  187
<211>  1392
<212>  DNA
<213>  Homo sapiens

<400>  187
atgccctgga ggaggcgcag gaaccgggtg agtgccctgg agggcggccg ggaggaagag     60

gcgcccccgg aggctgccgc tgtgcctccg gcgctgttaa cgtccccgca gcagacggag    120

gcggcggccg agcggattct gctccggggc atcttcgaga tcgggaggga cagttgtgac    180

gtggtgctga gcgagcgagc actgcggtgg cggcccattc agcccgagcg cccggcgggt    240

gattctaagt atgacttgct atgtaaagaa gaatttattg aactcaaaga catattctct    300

gtgaaactga aacggcgttg ttctgttaaa cagcagagaa gtggtacttt attaggtatc    360

acactcttca tctgcttgaa aaaggaacaa aataaactaa agaattctac acttgatctt    420

attaatttaa gtgaagacca ctgtgacata tggtttagac agttcaagaa aatattggca    480

ggctttccaa acagaccgaa gtcattaaaa atactcctta acccccaaag tcacaaaaaa    540

gaagctaccc aggtttatta tgagaaggtt gaacctctgt tgaagcttgc aggaataaaa    600

actgatgtaa caagatctac caatgtattg gcacattctc ttcatggagt tcctcatgtg    660

ataactgcaa cattgcacat tataatgggg catgtacagc tggtcgacgt ctgcaccttc    720

agcaccgctg gcaagcttct tcgctttggg ttctcagcca tgtttggctt tggtggaaga    780

actttggctc tggcagaaaa atatcgatgg atgtccccta accaacggag agattttgct    840

gttgttaagg cactggcaaa acttaaggca gaagactgtg aaatatcatt tttaccattt    900

aacagctctg atgatgtgca agaaaggagg gcacagggat ctcccaaatc tgactgtaat    960

gatcaatggc aaatgatcca gggtcagttc ttgaatgtca gcattatggc aattccttgc   1020

ctgtgttcag tggcacctag aggcttggca cctaatacca gattaaataa tggaagtatg   1080

gctcttataa ttgcccgaaa cacttctcgg ccagaattta taaaacacct gaaaagatat   1140

gccagtgtaa aaaatcagtt caattttcca tttgttgaga cttacactgt tgaggaagta   1200

aaagttcatc caaggaataa tactggtgga tataatccag aggaggagga ggatgaaact   1260

gcttcagaaa attgtttccc ttggaatgta gatggtgact taatggaagt tgcatcagag   1320

gtccatatta gattgcatcc aagacttatc agtctttatg gaggaagcat ggaagaaatg   1380

attccaaagt aa                                                       1392


<210>  188
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  188

Met Pro Trp Arg Arg Arg Arg Asn Arg Val Ser Ala Leu Glu Gly Gly 
1               5                   10                  15


Arg Glu Glu Glu Ala Pro Pro Glu Ala Ala Ala Val Pro Pro Ala Leu 
            20                  25                  30


Leu Thr Ser Pro Gln Gln Thr Glu Ala Ala Ala Glu Arg Ile Leu Leu 
        35                  40                  45


Arg Gly Ile Phe Glu Ile Gly Arg Asp Ser Cys Asp Val Val Leu Ser 
    50                  55                  60


Glu Arg Ala Leu Arg Trp Arg Pro Ile Gln Pro Glu Arg Pro Ala Gly 
65                  70                  75                  80


Asp Ser Lys Tyr Asp Leu Leu Cys Lys Glu Glu Phe Ile Glu Leu Lys 
                85                  90                  95


Asp Ile Phe Ser Val Lys Leu Lys Arg Arg Cys Ser Val Lys Gln Gln 
            100                 105                 110


Arg Ser Gly Thr Leu Leu Gly Ile Thr Leu Phe Ile Cys Leu Lys Lys 
        115                 120                 125


Glu Gln Asn Lys Leu Lys Asn Ser Thr Leu Asp Leu Ile Asn Leu Ser 
    130                 135                 140


Glu Asp His Cys Asp Ile Trp Phe Arg Gln Phe Lys Lys Ile Leu Ala 
145                 150                 155                 160


Gly Phe Pro Asn Arg Pro Lys Ser Leu Lys Ile Leu Leu Asn Pro Gln 
                165                 170                 175


Ser His Lys Lys Glu Ala Thr Gln Val Tyr Tyr Glu Lys Val Glu Pro 
            180                 185                 190


Leu Leu Lys Leu Ala Gly Ile Lys Thr Asp Val Thr Arg Ser Thr Asn 
        195                 200                 205


Val Leu Ala His Ser Leu His Gly Val Pro His Val Ile Thr Ala Thr 
    210                 215                 220


Leu His Ile Ile Met Gly His Val Gln Leu Val Asp Val Cys Thr Phe 
225                 230                 235                 240


Ser Thr Ala Gly Lys Leu Leu Arg Phe Gly Phe Ser Ala Met Phe Gly 
                245                 250                 255


Phe Gly Gly Arg Thr Leu Ala Leu Ala Glu Lys Tyr Arg Trp Met Ser 
            260                 265                 270


Pro Asn Gln Arg Arg Asp Phe Ala Val Val Lys Ala Leu Ala Lys Leu 
        275                 280                 285


Lys Ala Glu Asp Cys Glu Ile Ser Phe Leu Pro Phe Asn Ser Ser Asp 
    290                 295                 300


Asp Val Gln Glu Arg Arg Ala Gln Gly Ser Pro Lys Ser Asp Cys Asn 
305                 310                 315                 320


Asp Gln Trp Gln Met Ile Gln Gly Gln Phe Leu Asn Val Ser Ile Met 
                325                 330                 335


Ala Ile Pro Cys Leu Cys Ser Val Ala Pro Arg Gly Leu Ala Pro Asn 
            340                 345                 350


Thr Arg Leu Asn Asn Gly Ser Met Ala Leu Ile Ile Ala Arg Asn Thr 
        355                 360                 365


Ser Arg Pro Glu Phe Ile Lys His Leu Lys Arg Tyr Ala Ser Val Lys 
    370                 375                 380


Asn Gln Phe Asn Phe Pro Phe Val Glu Thr Tyr Thr Val Glu Glu Val 
385                 390                 395                 400


Lys Val His Pro Arg Asn Asn Thr Gly Gly Tyr Asn Pro Glu Glu Glu 
                405                 410                 415


Glu Asp Glu Thr Ala Ser Glu Asn Cys Phe Pro Trp Asn Val Asp Gly 
            420                 425                 430


Asp Leu Met Glu Val Ala Ser Glu Val His Ile Arg Leu His Pro Arg 
        435                 440                 445


Leu Ile Ser Leu Tyr Gly Gly Ser Met Glu Glu Met Ile Pro Lys 
    450                 455                 460


<210>  189
<211>  3123
<212>  DNA
<213>  Homo sapiens

<400>  189
ccagcctgcg actccgccat gccctggagg aggcgcagga accgggtgag tgccctggag     60

ggcggccggg aggaagaggc gcccccggag gctgccgctg tgcctccggc gctgttaacg    120

tccccgcagc agacggaggc ggcggccgag cggattctgc tccggggcat cttcgagatc    180

gggagggaca gttgtgacgt ggtgctgagc gagcgagcac tgcggtggcg gcccattcag    240

cccgagcgcc cggcgggtga ttctaagtat gacttgctat gtaaagaaga atttattgaa    300

ctcaaagaca tattctctgt gaaactgaaa cggcgttgtt ctgttaaaca gcagagaagt    360

ggtactttat taggtatcac actcttcatc tgcttgaaaa aggaacaaaa taaactaaag    420

aattctacac ttgatcttat taatttaagt gaagaccact gtgacatatg gtttagacag    480

ttcaagaaaa tattggcagg ctttccaaac agaccgaagt cattaaaaat actccttaac    540

ccccaaagtc acaaaaaaga agctacccag gtttattatg agaaggttga acctctgttg    600

aagcttgcag gaataaaaac tgatgtaaca ataatggaat atgaagggca cgctctgtca    660

ctgcttaagg aatgtgaact ccagggattt gatggtgttg tctgtgttgg tggagatgga    720

tctgctagcg aagtagccca tgctttgctt ctgagagctc agaagaatgc tgggatggaa    780

acagaccgaa tcctgactcc tgtcagagca cagcttccac ttggcttaat accagcagga    840

tctaccaatg tattggcaca ttctcttcat ggagttcctc atgtgataac tgcaacattg    900

cacattataa tggggcatgt acagctggtc gacgtctgca ccttcagcac cgctggcaag    960

cttcttcgct ttgggttctc agccatgttt ggctttggtg gaagaacttt ggctctggca   1020

gaaaaatatc gatggatgtc ccctaaccaa cggagagatt ttgctgttgt taaggcactg   1080

gcaaaactta aggcagaaga ctgtgaaata tcatttttac catttaacag ctctgatgat   1140

gtgcaagaaa ggagggcaca gggatctccc aaatctgact gtaatgatca atggcaaatg   1200

atccagggtc agttcttgaa tgtcagcatt atggcaattc cttgcctgtg ttcagtggca   1260

cctagaggct tggcacctaa taccagatta aataatggaa gtatggctct tataattgcc   1320

cgaaacactt ctcggccaga atttataaaa cacctgaaaa gatatgccag tgtaaaaaat   1380

cagttcaatt ttccatttgt tgagacttac actgttgagg aagtaaaagt tcatccaagg   1440

aataatactg gtggatataa tccagaggag gaggaggatg aaactgcttc agaaaattgt   1500

ttcccttgga atgtagatgg tgatttaatg gaagttgcat cagaggtcca tattagattg   1560

catccaagac ttatcagtct ttatggagga agcatggaag aaatgattcc aaagtaacat   1620

gtaattgttt ctaaaagaaa tgtacaaact agaattttaa tataaagaaa tgtggccatg   1680

ctttaaacct gtggtcccca ccctttttgg gaccagtttc atggaagaca atttttccgt   1740

ggatggggga atggtttcag gatgaactgt tccacctcag atcatcaggc attagattct   1800

cttgaggaac atggcactct agatccctca cataccagtt caccatatgg ttcgcacttc   1860

tatgagaatc taatgctgct gctgatctga cagggggagg aactcagtaa tgctccattg   1920

ctctaacctc ctgctgtgtg gccaaacgga tatcctaata gaaattgatg ttactaacaa   1980

ttagcctcta gggctttaaa agtcaagatg aaatatcaat tcaaattctg tttttagata   2040

tcaattcaaa ttcttttttt tacaatgtgt ttattggaca cacaaaaaaa ctttgcaacc   2100

atcataatac atcaatattt aacctagata attctgaaat aatttggatt ctttcatttt   2160

tcaggatttg agctcatcaa ttatgttaaa tttcctatat tctgttacaa atataataca   2220

gatttcataa gtctgccttg attcactgct ccctaatcca gagcagttaa atttcaaaat   2280

cacatagtta tatagcctac ctgccaaaaa agaataaccc atccctgtct tcttaaagtg   2340

gtagggtttt aaaattcatg atacaagtaa caaagtaagt tgataacaaa tactattttg   2400

aactgggcaa aatctagccc aatatgtaat tgtgttcccc ttgtatctga gaggcctgtg   2460

ttggacaacc atagtactct gctttcactg tgctcagata acctgaaata tatagttgtt   2520

tctgagtagt tctgagtagg aaagaaccaa atgtaaattt ccttagagac catcctggag   2580

aagacagttc taaatcgggg cttgattttt catctatgat cctagatgtt ctcctgaaag   2640

aatgactagc ctttttataa cgatacaaag ttttttaaaa atacataaat gtcataaagt   2700

ttattcctgt gtatacacac tctgggttca ggaggttttg tgcttacatt tcactactca   2760

aatgccttcg caaatctcag aacattcctc accatcactg caggcctgtg aacagataac   2820

tttcatcaat taggatggct ggctagtggc agggacttca tataaagaaa tctttcccag   2880

aattgttttt ccacattgcc ttctaatttg atcactccct ataacagatg ttcaaaattc   2940

ggccacagct ctcttatgaa ggcagagtca gataaaatga tattctgcaa ttatctagat   3000

cataagcata aaataaatat tacaaaaatg attgtattta aagaaatttt ttaaaatcca   3060

gaaagtcatt taaaatagaa cctcatatag tatgaacaaa ctataaaaat attttacatt   3120

tca                                                                 3123


<210>  190
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  190

Met Pro Trp Arg Arg Arg Arg Asn Arg Val Ser Ala Leu Glu Gly Gly 
1               5                   10                  15


Arg Glu Glu Glu Ala Pro Pro Glu Ala Ala Ala Val Pro Pro Ala Leu 
            20                  25                  30


Leu Thr Ser Pro Gln Gln Thr Glu Ala Ala Ala Glu Arg Ile Leu Leu 
        35                  40                  45


Arg Gly Ile Phe Glu Ile Gly Arg Asp Ser Cys Asp Val Val Leu Ser 
    50                  55                  60


Glu Arg Ala Leu Arg Trp Arg Pro Ile Gln Pro Glu Arg Pro Ala Gly 
65                  70                  75                  80


Asp Ser Lys Tyr Asp Leu Leu Cys Lys Glu Glu Phe Ile Glu Leu Lys 
                85                  90                  95


Asp Ile Phe Ser Val Lys Leu Lys Arg Arg Cys Ser Val Lys Gln Gln 
            100                 105                 110


Arg Ser Gly Thr Leu Leu Gly Ile Thr Leu Phe Ile Cys Leu Lys Lys 
        115                 120                 125


Glu Gln Asn Lys Leu Lys Asn Ser Thr Leu Asp Leu Ile Asn Leu Ser 
    130                 135                 140


Glu Asp His Cys Asp Ile Trp Phe Arg Gln Phe Lys Lys Ile Leu Ala 
145                 150                 155                 160


Gly Phe Pro Asn Arg Pro Lys Ser Leu Lys Ile Leu Leu Asn Pro Gln 
                165                 170                 175


Ser His Lys Lys Glu Ala Thr Gln Val Tyr Tyr Glu Lys Val Glu Pro 
            180                 185                 190


Leu Leu Lys Leu Ala Gly Ile Lys Thr Asp Val Thr Ile Met Glu Tyr 
        195                 200                 205


Glu Gly His Ala Leu Ser Leu Leu Lys Glu Cys Glu Leu Gln Gly Phe 
    210                 215                 220


Asp Gly Val Val Cys Val Gly Gly Asp Gly Ser Ala Ser Glu Val Ala 
225                 230                 235                 240


His Ala Leu Leu Leu Arg Ala Gln Lys Asn Ala Gly Met Glu Thr Asp 
                245                 250                 255


Arg Ile Leu Thr Pro Val Arg Ala Gln Leu Pro Leu Gly Leu Ile Pro 
            260                 265                 270


Ala Gly Ser Thr Asn Val Leu Ala His Ser Leu His Gly Val Pro His 
        275                 280                 285


Val Ile Thr Ala Thr Leu His Ile Ile Met Gly His Val Gln Leu Val 
    290                 295                 300


Asp Val Cys Thr Phe Ser Thr Ala Gly Lys Leu Leu Arg Phe Gly Phe 
305                 310                 315                 320


Ser Ala Met Phe Gly Phe Gly Gly Arg Thr Leu Ala Leu Ala Glu Lys 
                325                 330                 335


Tyr Arg Trp Met Ser Pro Asn Gln Arg Arg Asp Phe Ala Val Val Lys 
            340                 345                 350


Ala Leu Ala Lys Leu Lys Ala Glu Asp Cys Glu Ile Ser Phe Leu Pro 
        355                 360                 365


Phe Asn Ser Ser Asp Asp Val Gln Glu Arg Arg Ala Gln Gly Ser Pro 
    370                 375                 380


Lys Ser Asp Cys Asn Asp Gln Trp Gln Met Ile Gln Gly Gln Phe Leu 
385                 390                 395                 400


Asn Val Ser Ile Met Ala Ile Pro Cys Leu Cys Ser Val Ala Pro Arg 
                405                 410                 415


Gly Leu Ala Pro Asn Thr Arg Leu Asn Asn Gly Ser Met Ala Leu Ile 
            420                 425                 430


Ile Ala Arg Asn Thr Ser Arg Pro Glu Phe Ile Lys His Leu Lys Arg 
        435                 440                 445


Tyr Ala Ser Val Lys Asn Gln Phe Asn Phe Pro Phe Val Glu Thr Tyr 
    450                 455                 460


Thr Val Glu Glu Val Lys Val His Pro Arg Asn Asn Thr Gly Gly Tyr 
465                 470                 475                 480


Asn Pro Glu Glu Glu Glu Asp Glu Thr Ala Ser Glu Asn Cys Phe Pro 
                485                 490                 495


Trp Asn Val Asp Gly Asp Leu Met Glu Val Ala Ser Glu Val His Ile 
            500                 505                 510


Arg Leu His Pro Arg Leu Ile Ser Leu Tyr Gly Gly Ser Met Glu Glu 
        515                 520                 525


Met Ile Pro Lys 
    530


<210>  191
<211>  12408
<212>  DNA
<213>  Homo sapiens

<400>  191
gagaccgctg caagtcccgg ggccctgcct ctatcgtcct aggggttccg cgggcaggag     60

caacccagaa gcaccggtga ggccagcgcg tcctcgcagc catgagcagt gagcaggata    120

aatcggccag caaagaaaaa tccaagaaac cagtaagatt tctaccacag ctgtctatgg    180

agaaattagc cagcaaagaa aagttcaagg caccagcaag agctttacca cagctgtcta    240

tggtgagtac aaagccccac tggcagcagg cagctccatc attccatttg agtgtaaagc    300

aggatgatga gagtccagaa ccatttagtg ttaaaaatga acagtcccat gctgaataca    360

tggaacgttt tggaaaaaag ggcaaattac cccaccaagt tgatgatagt tatgttggac    420

catctacttc caaatcaaag ggcaaatctc cacataaaga acgagaaaac tttagaagta    480

ctcttgttaa tgtcattatg caacaagatg ctgacttaga ctcagctgtc cctgatggaa    540

gcacaattcc aaaaccgacc gcttctgcta tagagaaaga catcttgaga tattactatt    600

atattcacca tggaattgat acagaccatg tagccccaat ggaagattct tggctagaac    660

acgtactgga tttagttcca caacatctga aagtcttcac tgacagcata gttacattat    720

ctgatgaaat gagagaggat tatcttctta gtgtaaggaa atccatagtt gattttgttt    780

taaaagatcc tcgagagaaa ggagatgata agaagacaga tgaacttcca gcccatcgtg    840

ctgaaatgga aattctgcca aaaccttgga ggaaatcttt tttagctgca agcagttata    900

ttagggatca cttgaatgca atgaacccca caatgctggc tgtactagat ttgtggcaca    960

ctaattttaa aaaattacgt ttagttgata tcaaagaatt tcataattgc caggatgcat   1020

tagagctgtc aagttttcag aacattatca tgagacacat ggactctgcc aaagagactc   1080

tacttaaaat gtggtttcca gaagtgcaga atatttatta ccaaggtaat aaaaaaaagc   1140

aattgccaac tggtgacagc agtgccaaat tggaatcttt tttcaactgt gctgctgcac   1200

ttatgacttt acagctgcag gacctcactt tagtctccat gcaagatttc acggacttaa   1260

ttgcacaacc cccagattct gttagagctt ttgaacatcc aggtttcatc atgaggctga   1320

ttcttgataa tgacaccatt aagtttgaac ctgagttgag tgactatata gatatctttc   1380

taaatgttta tgacgtcatg attaaagctg tcagttttgt gccaagagtt gagacaaaat   1440

tgtattccaa gtgggaaagt aagtctaaac caacaacctt gaagcccata attctgaatg   1500

aaattgtaga tgctcacaaa gaaaagatca aggaagttat tatgaaagag agtgtggcac   1560

ctactgagca cctcagactc tatgacaagt atgacttttt aattaccaga aaagctgagc   1620

gagatgttga taacttcctc gcagaaaatc atagttatga aaaaataata gatgaaattt   1680

gcaaatacca gaaactaata gaggaaatac agtacacatc cataaagact attcgtttag   1740

gaatgtttga aatgcactgt gaggaattaa tcagagcttt ggtgaagcga gcagatatta   1800

tttgtgggaa acttctagct aaaatgttca gagatcatca ggaagtaaat acaagattat   1860

gcgatgaatt tgagaggata gctgaaaaag ctcttagcac tcctccaaat acagcagaac   1920

taatggaaat gaaggcttac attcagaaag tggaggtaac tgatatgatt gaactagaac   1980

agagattagt ggattccaaa aactgcctcg ccttcctcat cgagtatgtc aacttttctc   2040

cagcagacat gaggctaaat aatagtgttt tccagtggta tggaaggatg ggagaaattt   2100

ttgaagaaca caggaaaatc attaaagaga aaatagaaca atatcaagaa ggtctgaagt   2160

tacggtgtga acggtttgtg gaggaattgg agagttatgc taagcaatca gaagaatttt   2220

attcatttgg agatcttcag gatgttcagc ggtacctaaa aaaggctcaa atactgaatg   2280

gaaagttgga tttagctgca gataagattg agcagtttaa tgctgaagag gaagcatttg   2340

gttggctacc atctgtatat cctcaacgta aaaaaatcca agatggcttg aacccttatc   2400

ttcgtcttta tgaaactgct gtcgaattta gcagcaacta tagagcatgg acagaagggc   2460

catatcataa agtgaatcca gaccaagtag aagcagatat tggaaattac tggagaggat   2520

tatataaact ggagaaaacc tttcatgatt ctccatatgc attggcaatg acaaaaaaag   2580

taagatcaaa ggtggaagat ttcaagcagc acattcctct cattcaagtg atctgtaatc   2640

ctggtttgcg ccccaggcac tgggaggcca tgtctgccat tgttggttac cctttgcagc   2700

catcagatga ctccacagtc tcctcttttt tagacatgaa tctggaacca tatatagacc   2760

gatttgaagg tattagtgaa gcagctagca aagaatattc tcttgaaaag gcgatggaga   2820

agatgattac tgagtgggat gcagtggaat ttgtcatcca ttcttataga gaaactggga   2880

catttatttt ggcatcagtt gatgaaattc agatgttgtt ggatgaccat attattaaaa   2940

cacaaactat gcgaggatct cctttcatta agccttatga aaaacaaatg agagaatggg   3000

agggcaagct cctactgctt caggagattc tggatgaatg gctcaaagtc caagccacgt   3060

ggctgtatct ggagcccatt ttcagctctc cagacattat gtctcaaatg cctgaggaag   3120

gcagacgatt tacagctgtg gataagacat ggagagatat aatgagaagt gtcatgcagg   3180

ataaacatgt tctgacagtt gtaaccattg acagaatgct ggaaaggctg aaaaaatcta   3240

atgaactttt ggagctcatt cttaaaggac ttaatgaata tttggaaaag aaacgcctct   3300

ttttccccag attctttttt ttgtccaatg atgaacttct tgagatacta tctgagacta   3360

aagatcccac tagggtgcaa cctcacttga agaaatgttt tgaaggaatc gcaaaggtag   3420

aatttacgga aactttagac attactcaca tgaagagcag cgaaggagag gttgtagaac   3480

tcatagagat tatttcaaca gccaaagcca gaggtcaagt ggagaagtgg ttggttgaat   3540

tagagagagt tatgattaac tccatccaca aggtaactgg agatgcaact tttgcctata   3600

caaaatatga acgaattaac tgggtaaggg attggcctgg acagactgtt ctctgtgtat   3660

cccaaatctt ttggacaaaa gaagtacaaa cagctattcc aatggggata aaggctcttg   3720

agcaatactt gaaaacatgt aacagacaaa ttgatgatat tgtcactttg gtgcgtggca   3780

aattgtccat gcagaatcgc gtaactctgg gagcacttgt ggtactggat gtccatgcta   3840

gagatgtcct ctcatcactt gtaaaaaaaa atattagcga tgactctgac tttgaatggt   3900

taagtcagct taggtactac tggcaagaaa atcatttaga aacaaaaatg atcaatgctg   3960

gtttgcgata tggatatgaa tatctgggta attcccctag gctggttatt acaccactca   4020

cggatagatg ttacagaacc ttatttggag cccttcattt gcaccttgga ggagcacctg   4080

agggtccagc tggcactggg aagactgaaa ctaccaagga tttggcaaaa gctgtagcca   4140

aacaatgtgt tgttttcaac tgctctgatg ggttggatta tttggctttg ggaaaattct   4200

ttaagggact gttatcttgt ggagcctggg cttgctttga tgagtttaac agaattgatt   4260

tggaagtact ctctgtggtt gctcaacaaa tccttactat ccaaagaggt attaatgcag   4320

gtgctgatat actgatgttt gaaggaactg aactaaaact tgaccccaca tgtgctgtct   4380

ttataacaat gaaccctggg tatgctgggc gatcagaact gccagataac ctgaaggctc   4440

tctttcggac agtagcaatg atggtacctg actatgccat gattgctgaa atagtcctat   4500

actcctgtgg gtttgtcact gctcgaccac tgtctgtaaa aattgtggct acgtatcgct   4560

tgtgttcaga gcagctgtca tctcaacatc actacgacta tggaatgaga gccgtgaagt   4620

cagttcttac tgctgctggg aatctgaagc tgaaatatcc aaatgaaaat gaagaaattt   4680

tgctgcttag atctatcatt gatgtaaatc tgccaaaatt tttatcccat gatttaccac   4740

tctttgaggg aattacttcg gatttgtttc ctggggtaaa attaccaaaa ccagattaca   4800

atgatttgct ggcagctatc aaagacaatt gtgcctccat gaatttgcaa atgactgcat   4860

tcttttccga gaagattctt caagtatatg aaatgatgat tgtgcgtcat ggttttatga   4920

ttgttggaga accatttgga ggaaaaacta gtgcatatcg tgtcttagct ggagcactaa   4980

atgatatatg tgaaaagggg ctaatggaag aaaacaaagt tcaaataact gttttaaatc   5040

ctaagtctgt caccatgggc caactgtacg gacagtttga ttcagtgtcc catgaatggt   5100

ctgatggggt ccttgctgtc agttttagag catttgcctc ttcagtgact ccagatagga   5160

aatggttaat ttttgatggc ccagtagatg cagtgtggat tgagaatatg aacactgtgc   5220

tggatgacaa caagaagcta tgtctgatga gtggggagat tattcagatg tcaccacaaa   5280

tgaatctaat ttttgagcca atggatttag aagttgcttc ccctgccact gtttccagat   5340

gtggcatgat ttacatggag cctcacatgt taggctggag accactgatg ttgtcctggg   5400

tgaatctgtt acctgcgtca gtcagtgtta ttcaaaagga attcataatg ggcttatttg   5460

acagaatggt ccctgtttcg gttgaattta ttagaaagca tacaaaggaa ttatctccta   5520

cttccgatac aaacttggtc cggtccttaa tgaatctaat agactgtttt atggatgatt   5580

ttgctgatga agtcaaacta aaggagagaa atgatcgaga aacttactct ttgcttgagg   5640

gcatttttct gttttcattg atctggtccg ttggtgcttc ttgtacagat gatgatcgat   5700

tgaaatttaa taagattctt cgagaactaa tggaaagtcc aatttcagat cgaactcgaa   5760

atacgtttaa attacagagt ggtactgagc aaacatcctc aaaggcacta actgtcccat   5820

ttcctgaaaa aggaacaatt tatgattatc aatttgtcac tgagggaata ggaaaatggg   5880

aaccatggat aaagaaattg aaagaagctc ctccaattcc taaagatgta atgtttaatg   5940

aaatcattgt gccaactctg gacacaattc gatactctgc attaatggaa ttgctgacca   6000

cccatcaaaa gccttcaata tttgtaggac caacaggaac tgggaaaagt gtttacatta   6060

cgaattttct tttaaatcaa ctaaataagg aaatctacaa acctctgcta attaacttct   6120

cagcacaaac tacagcagct caaactcaga atattgtcat gtcaaaattg gacaagagaa   6180

gaaagggagt ttttggtcct cctttgggca agagaatggt tgtctttgta gatgatgtca   6240

atatgcctgc tcgggaggta tatggggctc aacctcccat tgagttactt agacagtggt   6300

tagaccactg gaactggtat gatctaaaag attgttccat gattaaacta gtggacattc   6360

agatcatgtg tgctatggga cctccaggtg gtggtcgaaa tccagtaact cctcgataca   6420

tgcgacattt caatattata acaatcaatg agtttagtga taaatccatg tatacaatct   6480

tctctagaat cttaacttgg catttagaaa tctgttataa atttccagat gaatttctag   6540

atttgaccac acaaatcgta aatggcacaa tgactctgta taaagaagca atgaagaatc   6600

tcttgcctac tccagctaaa tctcactact tgttcaacct ccgtgatttc tcccgtgtca   6660

ttcaaggtgt ttgtttgtca agaccagaaa caacagaaac cacagaagtg attaaacgtc   6720

tttgggttca tgaggtcctt cgagtgtatt atgaccgcct tctggacaat acagacagaa   6780

gctggctcat caactacatt caagaaattt tgagaaacta catgtatgaa gattttcatg   6840

agctttttca gcgtttggat tttgataatg atggcatggt ggaagcagat gacttacgca   6900

gcttaatgtt ttgtgatttc catgatccca agagggagga taccaactac agagaaatcg   6960

cagatgtgga taatcttcga atgatagtag aaattcacct agaagaatac aacaatataa   7020

gcaaaaaacc catgaacctt gtcttgtttc gatttgccat agagcacatc agcagaattt   7080

ccaggatcct gaagcagcct cgcagccatg ctctcctagt aggggttgga gggagtggaa   7140

ggcagtctgt caccagatta gctgcccaca tggctgatta ttcagttttc caagttgaaa   7200

tctctaaggg gtatgatact actgaatggc atgaagattt aaaagtgatc ttaaggaaat   7260

gtgcggaagg tgagatgcag ggtgtcttcc tgtttacaga tactcaaatt aaagaagagt   7320

cttttctgga agatgtcagt aatctgctaa atgctgggga gattccaaat ctctttgcat   7380

tagatgagaa gcaagagata tgtgataaga tgcgtcagtt agatcgccag cgggataaaa   7440

ccaagcaaac agatggcagc cccatagccc ttttcaacat gtttattgat cattgccgca   7500

gccaactgca tgtggtcctt gccatgagtc ccattggaga tgcatttcgg aatcgtctta   7560

gaaagttccc tgctcttgtt aactgctgta ccattgactg gtttcagtca tggcctgaag   7620

atgcactcca ggcagttgcc tcacgattct tggaagaaat tgaaatgtca gaggaaatac   7680

gagatggctg tatcgacatg tgtaaaagct tccacacttc tactatagat ttatccaaat   7740

ctttctttgt tgaacttcaa agatacaatt atgtgactcc tacctcttac ctcgaattaa   7800

tctccacctt caaactgttg ttagaaaaga aaagaagtga agtaatgaaa atgaaaaaga   7860

gatatgaagt gggtttggag aaactggatt ctgcttcatc tcaagtagcc acaatgcaga   7920

tggagttgga ggcactacat cctcaattaa aagttgctag caaagaggtt gatgaaatga   7980

tgataatgat tgagaaagag tctgtagaag ttgccaaaac tgaaaaaata gtgaaagctg   8040

atgaaacaat agcgaatgaa caagctatgg cttccaaagc catcaaagat gagtgcgatg   8100

ctgacctggc aggtgccttg ccaatattag agtcagcact ggccgccctt gatactctta   8160

ctgcacagga tattacagtg gtaaaatcca tgaagagtcc tcctgctggt gtcaagcttg   8220

ttatggaagc tatatgcatc ttgaaaggaa tcaaagctga caaaatccct gacccaacag   8280

gttcagggaa aaaaattgag gatttctggg gcccagctaa gagacttctt ggtgacatga   8340

ggtttctgca gtcacttcat gaatatgaca aggacaatat tcctccagct tatatgaata   8400

tcataagaaa aaattatatt ccaaatccag attttgtacc agaaaaaatc agaaatgctt   8460

ctacagcggc cgaaggtctg tgcaaatggg tcatagcaat ggattcatat gataaagtgg   8520

caaaaatagt agctcccaaa aagataaaac tggctgcagc tgaaggggag cttaaaattg   8580

ccatggatgg tcttagaaag aagcaggcag cccttaagga agttcaggac aagctggcca   8640

ggcttcaaga cacacttgaa ttaaataaac aaaagaaggc tgacctggaa aaccaggttg   8700

acctttgcag caaaaaacta gaacgagctg aacagttgat tggaggcctt ggaggtgaga   8760

aaactcgatg gagccacaca gctctggagc taggtcagct gtacatcaac ttgactgggg   8820

atatcctcat ttcctccgga gtggttgctt acctcggagc cttcacatcc acctatagac   8880

agaatcaaac taaagagtgg acaactttgt gcaaaggaag agatatcccc tgctcagatg   8940

attgctctct tatgggtacc ctgggagaag ctgtgacaat tcgaacttgg aatattgctg   9000

gattaccttc tgactcattt tccattgata atgggataat cataatgaat gcaagaaggt   9060

ggcctctgat gatagatcct caaagtcagg ctaataaatg gatcaagaac atggaaaaag   9120

ccaatagtct ttatgtgatt aaacttagtg aacctgacta tgtcaggact ctggaaaatt   9180

gcatccagtt tggtactcct gtgttgctag aaaatgttgg cgaagaacta gatcctattt   9240

tggaacctct tctactaaaa caaaccttta agcagggtgg gagtacatgt atccggcttg   9300

gggactccac aattgaatat gcacctgact tccgcttcta tattactacc aagttaagaa   9360

atcctcatta tcttcctgaa acatcagtaa aggtaacatt attaaacttc atgataaccc   9420

ctgagggaat gcaagatcag cttctgggaa ttgtggtggc acaagaaagg ccagaccttg   9480

aagaagaaaa gcaagccttg atattacaag gagctgaaaa taaaaggcag ttaaaagaaa   9540

tagaagacaa gattttagaa gttctttcat cttcggaagg caatatatta gaagatgaaa   9600

ctgctattaa gatattatct tcctccaagg ccttggctaa tgagatttct cagaagcagg   9660

aagtagccga agagacagag aaaaagattg acaccacccg catgggctat cgtcctattg   9720

ccatccattc ttccatccta tttttttctc ttgctgattt agccaacatt gagcccatgt   9780

accagtattc actgacctgg tttattaacc ttttcatcct gtctattgaa aattcagaga   9840

aatcagaaat tttggcaaaa aggcttcaga ttctcaagga tcactttact tattcactgt   9900

atgttaatgt ctgccggtca ctctttgaaa aggataagct gctcttttcc ttttgtctaa   9960

ccataaatct actgctgcat gagcgggcga ttaataaagc tgagtggaga tttctgctaa  10020

ctggtggcat tggactggat aatccttatg ccaacctttg tacatggctt cctcagaaat  10080

cctgggatga aatatgtcga ttagatgatt tgcctgcctt caaaaccatt cgtagagagt  10140

ttatgcgctt aaaggatgga tggaagaaag tatatgatag tttggaacca caccatgagg  10200

ttttccctga agaatgggaa gataaagcaa atgagtttca aaggatgctt attattcgtt  10260

gcttgaggcc agacaaggtt attccaatgt tgcaggaatt tataatcaac agattgggac  10320

gtgcattcat tgaaccaccc ccctttgatt tagccaaggc atttggagac agtaactgct  10380

gtgcaccact gattttcgtg ctctctcctg gagcagatcc catggctgcc cttctaaaat  10440

ttgctgatga ccagggatat gggggatcaa aacttagctc tttatctctt ggtcaaggcc  10500

aagggcccat tgctatgaag atgttagaaa aagctgtcaa ggaaggaaca tgggttgttc  10560

ttcagaattg tcaccttgcc acctcttgga tgccaaccct tgagaaagtc tgtgaggagt  10620

taagcccaga gtcaacacat ccagatttcc gaatgtggct aacgagttac ccatctccaa  10680

atttccctgt gtcagtactg cagaatggag tgaaaatgac caatgaagca ccaaaaggtt  10740

tacgggctaa tatcattcga tcatacctca tggacccgat ctctgatccg gagttctttg  10800

gcagctgcaa aaagcctgag gaattcaaga aattgcttta tggcctgtgt ttctttcatg  10860

ctttggtaca agaaagacgg aaatttggac ccctagggtg gaatattcct tatgagttca  10920

atgagacaga tctgagaatc agcgtacagc agctccacat gttcctgaac cagtatgagg  10980

aactgccgta tgaggctctg cggtacatga ctggcgaatg caattacgga ggcagagtga  11040

ccgatgactg ggaccggcgc acgctgcgca gcattctaaa caaattcttc aatcccgaat  11100

tagttgaaaa ttcagactat aagttcgact caagtggcat ctattttgtt cctccttctg  11160

gtgatcacaa aagctacatc gaatacacaa agactctgcc actgacccca gcaccagaaa  11220

tctttgggat gaatgccaat gcagatatca ctaaggatca gtcagaaact cagctgctat  11280

ttgataacat tcttcttaca cagtctcgtt cagcaggtgc tggtgcaaaa tcatcagatg  11340

aagtagtgaa tgaggtcgct agtgacatct tgggcaaact tccaaacaac ttcgacatcg  11400

aggctgccat gaggaggtac ccaacaactt atactcagag catgaacact gtacttgtcc  11460

aagagatggg acggttcaat aagttactga agaccataag agattcgtgc gtaaatattc  11520

aaaaagcaat caaggggctt gcagtcatgt ctacagatct tgaagaagtg gttagcagca  11580

ttttgaatgt caaaattcca gaaatgtgga tgggtaaatc ctacccaagc cttaaaccac  11640

ttggcagcta tgtgaatgac ttccttgcaa gactaaaatt cttgcagcaa tggtatgagg  11700

ttggtcctcc tccagtcttc tggctttctg gcttcttctt cacacaagcc ttcctgaccg  11760

gtgcccagca gaactacgcc aggaaataca caattcctat tgatcttctt gggtttgact  11820

atgaagtgat ggaagacaaa gaatacaagc atcctcctga ggatggtgtt ttcattcacg  11880

gattatttct ggatggagct tcctggaata gaaagatcaa gaaacttgca gaatcgcatc  11940

ccaaaattct ttatgataca gtgcctgtga tgtggctaaa gccctgtaag agggcagata  12000

taccaaaacg gccaagttat gttgctccat tgtataagac aagtgagcgg agaggagtat  12060

tatccaccac tggccattcc acgaattttg tgattgccat gactcttccc tctgaccaac  12120

ccaaggaaca ctggattgga cgaggtgtag cactgttatg tcaacttaat tcataaccag  12180

aagacatcat ttccttgttc ctatttcttg ttggctggct gagtagagaa agcatatttt  12240

actacttaaa cctttttttt tgtttgttta aatacatttg actaaagtta taattatgaa  12300

tttacttatg agcaaatgca gctaaactta atatgactca tacttaaatg taaggaaatg  12360

ttctgaaata aagactaaag aaaacacact ggcaaaaaaa aaaaaaaa               12408


<210>  192
<211>  4024
<212>  PRT
<213>  Homo sapiens

<400>  192

Met Ser Ser Glu Gln Asp Lys Ser Ala Ser Lys Glu Lys Ser Lys Lys 
1               5                   10                  15


Pro Val Arg Phe Leu Pro Gln Leu Ser Met Glu Lys Leu Ala Ser Lys 
            20                  25                  30


Glu Lys Phe Lys Ala Pro Ala Arg Ala Leu Pro Gln Leu Ser Met Val 
        35                  40                  45


Ser Thr Lys Pro His Trp Gln Gln Ala Ala Pro Ser Phe His Leu Ser 
    50                  55                  60


Val Lys Gln Asp Asp Glu Ser Pro Glu Pro Phe Ser Val Lys Asn Glu 
65                  70                  75                  80


Gln Ser His Ala Glu Tyr Met Glu Arg Phe Gly Lys Lys Gly Lys Leu 
                85                  90                  95


Pro His Gln Val Asp Asp Ser Tyr Val Gly Pro Ser Thr Ser Lys Ser 
            100                 105                 110


Lys Gly Lys Ser Pro His Lys Glu Arg Glu Asn Phe Arg Ser Thr Leu 
        115                 120                 125


Val Asn Val Ile Met Gln Gln Asp Ala Asp Leu Asp Ser Ala Val Pro 
    130                 135                 140


Asp Gly Ser Thr Ile Pro Lys Pro Thr Ala Ser Ala Ile Glu Lys Asp 
145                 150                 155                 160


Ile Leu Arg Tyr Tyr Tyr Tyr Ile His His Gly Ile Asp Thr Asp His 
                165                 170                 175


Val Ala Pro Met Glu Asp Ser Trp Leu Glu His Val Leu Asp Leu Val 
            180                 185                 190


Pro Gln His Leu Lys Val Phe Thr Asp Ser Ile Val Thr Leu Ser Asp 
        195                 200                 205


Glu Met Arg Glu Asp Tyr Leu Leu Ser Val Arg Lys Ser Ile Val Asp 
    210                 215                 220


Phe Val Leu Lys Asp Pro Arg Glu Lys Gly Asp Asp Lys Lys Thr Asp 
225                 230                 235                 240


Glu Leu Pro Ala His Arg Ala Glu Met Glu Ile Leu Pro Lys Pro Trp 
                245                 250                 255


Arg Lys Ser Phe Leu Ala Ala Ser Ser Tyr Ile Arg Asp His Leu Asn 
            260                 265                 270


Ala Met Asn Pro Thr Met Leu Ala Val Leu Asp Leu Trp His Thr Asn 
        275                 280                 285


Phe Lys Lys Leu Arg Leu Val Asp Ile Lys Glu Phe His Asn Cys Gln 
    290                 295                 300


Asp Ala Leu Glu Leu Ser Ser Phe Gln Asn Ile Ile Met Arg His Met 
305                 310                 315                 320


Asp Ser Ala Lys Glu Thr Leu Leu Lys Met Trp Phe Pro Glu Val Gln 
                325                 330                 335


Asn Ile Tyr Tyr Gln Gly Asn Lys Lys Lys Gln Leu Pro Thr Gly Asp 
            340                 345                 350


Ser Ser Ala Lys Leu Glu Ser Phe Phe Asn Cys Ala Ala Ala Leu Met 
        355                 360                 365


Thr Leu Gln Leu Gln Asp Leu Thr Leu Val Ser Met Gln Asp Phe Thr 
    370                 375                 380


Asp Leu Ile Ala Gln Pro Pro Asp Ser Val Arg Ala Phe Glu His Pro 
385                 390                 395                 400


Gly Phe Ile Met Arg Leu Ile Leu Asp Asn Asp Thr Ile Lys Phe Glu 
                405                 410                 415


Pro Glu Leu Ser Asp Tyr Ile Asp Ile Phe Leu Asn Val Tyr Asp Val 
            420                 425                 430


Met Ile Lys Ala Val Ser Phe Val Pro Arg Val Glu Thr Lys Leu Tyr 
        435                 440                 445


Ser Lys Trp Glu Ser Lys Ser Lys Pro Thr Thr Leu Lys Pro Ile Ile 
    450                 455                 460


Leu Asn Glu Ile Val Asp Ala His Lys Glu Lys Ile Lys Glu Val Ile 
465                 470                 475                 480


Met Lys Glu Ser Val Ala Pro Thr Glu His Leu Arg Leu Tyr Asp Lys 
                485                 490                 495


Tyr Asp Phe Leu Ile Thr Arg Lys Ala Glu Arg Asp Val Asp Asn Phe 
            500                 505                 510


Leu Ala Glu Asn His Ser Tyr Glu Lys Ile Ile Asp Glu Ile Cys Lys 
        515                 520                 525


Tyr Gln Lys Leu Ile Glu Glu Ile Gln Tyr Thr Ser Ile Lys Thr Ile 
    530                 535                 540


Arg Leu Gly Met Phe Glu Met His Cys Glu Glu Leu Ile Arg Ala Leu 
545                 550                 555                 560


Val Lys Arg Ala Asp Ile Ile Cys Gly Lys Leu Leu Ala Lys Met Phe 
                565                 570                 575


Arg Asp His Gln Glu Val Asn Thr Arg Leu Cys Asp Glu Phe Glu Arg 
            580                 585                 590


Ile Ala Glu Lys Ala Leu Ser Thr Pro Pro Asn Thr Ala Glu Leu Met 
        595                 600                 605


Glu Met Lys Ala Tyr Ile Gln Lys Val Glu Val Thr Asp Met Ile Glu 
    610                 615                 620


Leu Glu Gln Arg Leu Val Asp Ser Lys Asn Cys Leu Ala Phe Leu Ile 
625                 630                 635                 640


Glu Tyr Val Asn Phe Ser Pro Ala Asp Met Arg Leu Asn Asn Ser Val 
                645                 650                 655


Phe Gln Trp Tyr Gly Arg Met Gly Glu Ile Phe Glu Glu His Arg Lys 
            660                 665                 670


Ile Ile Lys Glu Lys Ile Glu Gln Tyr Gln Glu Gly Leu Lys Leu Arg 
        675                 680                 685


Cys Glu Arg Phe Val Glu Glu Leu Glu Ser Tyr Ala Lys Gln Ser Glu 
    690                 695                 700


Glu Phe Tyr Ser Phe Gly Asp Leu Gln Asp Val Gln Arg Tyr Leu Lys 
705                 710                 715                 720


Lys Ala Gln Ile Leu Asn Gly Lys Leu Asp Leu Ala Ala Asp Lys Ile 
                725                 730                 735


Glu Gln Phe Asn Ala Glu Glu Glu Ala Phe Gly Trp Leu Pro Ser Val 
            740                 745                 750


Tyr Pro Gln Arg Lys Lys Ile Gln Asp Gly Leu Asn Pro Tyr Leu Arg 
        755                 760                 765


Leu Tyr Glu Thr Ala Val Glu Phe Ser Ser Asn Tyr Arg Ala Trp Thr 
    770                 775                 780


Glu Gly Pro Tyr His Lys Val Asn Pro Asp Gln Val Glu Ala Asp Ile 
785                 790                 795                 800


Gly Asn Tyr Trp Arg Gly Leu Tyr Lys Leu Glu Lys Thr Phe His Asp 
                805                 810                 815


Ser Pro Tyr Ala Leu Ala Met Thr Lys Lys Val Arg Ser Lys Val Glu 
            820                 825                 830


Asp Phe Lys Gln His Ile Pro Leu Ile Gln Val Ile Cys Asn Pro Gly 
        835                 840                 845


Leu Arg Pro Arg His Trp Glu Ala Met Ser Ala Ile Val Gly Tyr Pro 
    850                 855                 860


Leu Gln Pro Ser Asp Asp Ser Thr Val Ser Ser Phe Leu Asp Met Asn 
865                 870                 875                 880


Leu Glu Pro Tyr Ile Asp Arg Phe Glu Gly Ile Ser Glu Ala Ala Ser 
                885                 890                 895


Lys Glu Tyr Ser Leu Glu Lys Ala Met Glu Lys Met Ile Thr Glu Trp 
            900                 905                 910


Asp Ala Val Glu Phe Val Ile His Ser Tyr Arg Glu Thr Gly Thr Phe 
        915                 920                 925


Ile Leu Ala Ser Val Asp Glu Ile Gln Met Leu Leu Asp Asp His Ile 
    930                 935                 940


Ile Lys Thr Gln Thr Met Arg Gly Ser Pro Phe Ile Lys Pro Tyr Glu 
945                 950                 955                 960


Lys Gln Met Arg Glu Trp Glu Gly Lys Leu Leu Leu Leu Gln Glu Ile 
                965                 970                 975


Leu Asp Glu Trp Leu Lys Val Gln Ala Thr Trp Leu Tyr Leu Glu Pro 
            980                 985                 990


Ile Phe Ser Ser Pro Asp Ile Met Ser Gln Met Pro Glu Glu Gly Arg 
        995                 1000                1005


Arg Phe Thr Ala Val Asp Lys Thr Trp Arg Asp Ile Met Arg Ser Val 
    1010                1015                1020


Met Gln Asp Lys His Val Leu Thr Val Val Thr Ile Asp Arg Met Leu 
1025                1030                1035                1040


Glu Arg Leu Lys Lys Ser Asn Glu Leu Leu Glu Leu Ile Leu Lys Gly 
                1045                1050                1055


Leu Asn Glu Tyr Leu Glu Lys Lys Arg Leu Phe Phe Pro Arg Phe Phe 
            1060                1065                1070


Phe Leu Ser Asn Asp Glu Leu Leu Glu Ile Leu Ser Glu Thr Lys Asp 
        1075                1080                1085


Pro Thr Arg Val Gln Pro His Leu Lys Lys Cys Phe Glu Gly Ile Ala 
    1090                1095                1100


Lys Val Glu Phe Thr Glu Thr Leu Asp Ile Thr His Met Lys Ser Ser 
1105                1110                1115                1120


Glu Gly Glu Val Val Glu Leu Ile Glu Ile Ile Ser Thr Ala Lys Ala 
                1125                1130                1135


Arg Gly Gln Val Glu Lys Trp Leu Val Glu Leu Glu Arg Val Met Ile 
            1140                1145                1150


Asn Ser Ile His Lys Val Thr Gly Asp Ala Thr Phe Ala Tyr Thr Lys 
        1155                1160                1165


Tyr Glu Arg Ile Asn Trp Val Arg Asp Trp Pro Gly Gln Thr Val Leu 
    1170                1175                1180


Cys Val Ser Gln Ile Phe Trp Thr Lys Glu Val Gln Thr Ala Ile Pro 
1185                1190                1195                1200


Met Gly Ile Lys Ala Leu Glu Gln Tyr Leu Lys Thr Cys Asn Arg Gln 
                1205                1210                1215


Ile Asp Asp Ile Val Thr Leu Val Arg Gly Lys Leu Ser Met Gln Asn 
            1220                1225                1230


Arg Val Thr Leu Gly Ala Leu Val Val Leu Asp Val His Ala Arg Asp 
        1235                1240                1245


Val Leu Ser Ser Leu Val Lys Lys Asn Ile Ser Asp Asp Ser Asp Phe 
    1250                1255                1260


Glu Trp Leu Ser Gln Leu Arg Tyr Tyr Trp Gln Glu Asn His Leu Glu 
1265                1270                1275                1280


Thr Lys Met Ile Asn Ala Gly Leu Arg Tyr Gly Tyr Glu Tyr Leu Gly 
                1285                1290                1295


Asn Ser Pro Arg Leu Val Ile Thr Pro Leu Thr Asp Arg Cys Tyr Arg 
            1300                1305                1310


Thr Leu Phe Gly Ala Leu His Leu His Leu Gly Gly Ala Pro Glu Gly 
        1315                1320                1325


Pro Ala Gly Thr Gly Lys Thr Glu Thr Thr Lys Asp Leu Ala Lys Ala 
    1330                1335                1340


Val Ala Lys Gln Cys Val Val Phe Asn Cys Ser Asp Gly Leu Asp Tyr 
1345                1350                1355                1360


Leu Ala Leu Gly Lys Phe Phe Lys Gly Leu Leu Ser Cys Gly Ala Trp 
                1365                1370                1375


Ala Cys Phe Asp Glu Phe Asn Arg Ile Asp Leu Glu Val Leu Ser Val 
            1380                1385                1390


Val Ala Gln Gln Ile Leu Thr Ile Gln Arg Gly Ile Asn Ala Gly Ala 
        1395                1400                1405


Asp Ile Leu Met Phe Glu Gly Thr Glu Leu Lys Leu Asp Pro Thr Cys 
    1410                1415                1420


Ala Val Phe Ile Thr Met Asn Pro Gly Tyr Ala Gly Arg Ser Glu Leu 
1425                1430                1435                1440


Pro Asp Asn Leu Lys Ala Leu Phe Arg Thr Val Ala Met Met Val Pro 
                1445                1450                1455


Asp Tyr Ala Met Ile Ala Glu Ile Val Leu Tyr Ser Cys Gly Phe Val 
            1460                1465                1470


Thr Ala Arg Pro Leu Ser Val Lys Ile Val Ala Thr Tyr Arg Leu Cys 
        1475                1480                1485


Ser Glu Gln Leu Ser Ser Gln His His Tyr Asp Tyr Gly Met Arg Ala 
    1490                1495                1500


Val Lys Ser Val Leu Thr Ala Ala Gly Asn Leu Lys Leu Lys Tyr Pro 
1505                1510                1515                1520


Asn Glu Asn Glu Glu Ile Leu Leu Leu Arg Ser Ile Ile Asp Val Asn 
                1525                1530                1535


Leu Pro Lys Phe Leu Ser His Asp Leu Pro Leu Phe Glu Gly Ile Thr 
            1540                1545                1550


Ser Asp Leu Phe Pro Gly Val Lys Leu Pro Lys Pro Asp Tyr Asn Asp 
        1555                1560                1565


Leu Leu Ala Ala Ile Lys Asp Asn Cys Ala Ser Met Asn Leu Gln Met 
    1570                1575                1580


Thr Ala Phe Phe Ser Glu Lys Ile Leu Gln Val Tyr Glu Met Met Ile 
1585                1590                1595                1600


Val Arg His Gly Phe Met Ile Val Gly Glu Pro Phe Gly Gly Lys Thr 
                1605                1610                1615


Ser Ala Tyr Arg Val Leu Ala Gly Ala Leu Asn Asp Ile Cys Glu Lys 
            1620                1625                1630


Gly Leu Met Glu Glu Asn Lys Val Gln Ile Thr Val Leu Asn Pro Lys 
        1635                1640                1645


Ser Val Thr Met Gly Gln Leu Tyr Gly Gln Phe Asp Ser Val Ser His 
    1650                1655                1660


Glu Trp Ser Asp Gly Val Leu Ala Val Ser Phe Arg Ala Phe Ala Ser 
1665                1670                1675                1680


Ser Val Thr Pro Asp Arg Lys Trp Leu Ile Phe Asp Gly Pro Val Asp 
                1685                1690                1695


Ala Val Trp Ile Glu Asn Met Asn Thr Val Leu Asp Asp Asn Lys Lys 
            1700                1705                1710


Leu Cys Leu Met Ser Gly Glu Ile Ile Gln Met Ser Pro Gln Met Asn 
        1715                1720                1725


Leu Ile Phe Glu Pro Met Asp Leu Glu Val Ala Ser Pro Ala Thr Val 
    1730                1735                1740


Ser Arg Cys Gly Met Ile Tyr Met Glu Pro His Met Leu Gly Trp Arg 
1745                1750                1755                1760


Pro Leu Met Leu Ser Trp Val Asn Leu Leu Pro Ala Ser Val Ser Val 
                1765                1770                1775


Ile Gln Lys Glu Phe Ile Met Gly Leu Phe Asp Arg Met Val Pro Val 
            1780                1785                1790


Ser Val Glu Phe Ile Arg Lys His Thr Lys Glu Leu Ser Pro Thr Ser 
        1795                1800                1805


Asp Thr Asn Leu Val Arg Ser Leu Met Asn Leu Ile Asp Cys Phe Met 
    1810                1815                1820


Asp Asp Phe Ala Asp Glu Val Lys Leu Lys Glu Arg Asn Asp Arg Glu 
1825                1830                1835                1840


Thr Tyr Ser Leu Leu Glu Gly Ile Phe Leu Phe Ser Leu Ile Trp Ser 
                1845                1850                1855


Val Gly Ala Ser Cys Thr Asp Asp Asp Arg Leu Lys Phe Asn Lys Ile 
            1860                1865                1870


Leu Arg Glu Leu Met Glu Ser Pro Ile Ser Asp Arg Thr Arg Asn Thr 
        1875                1880                1885


Phe Lys Leu Gln Ser Gly Thr Glu Gln Thr Ser Ser Lys Ala Leu Thr 
    1890                1895                1900


Val Pro Phe Pro Glu Lys Gly Thr Ile Tyr Asp Tyr Gln Phe Val Thr 
1905                1910                1915                1920


Glu Gly Ile Gly Lys Trp Glu Pro Trp Ile Lys Lys Leu Lys Glu Ala 
                1925                1930                1935


Pro Pro Ile Pro Lys Asp Val Met Phe Asn Glu Ile Ile Val Pro Thr 
            1940                1945                1950


Leu Asp Thr Ile Arg Tyr Ser Ala Leu Met Glu Leu Leu Thr Thr His 
        1955                1960                1965


Gln Lys Pro Ser Ile Phe Val Gly Pro Thr Gly Thr Gly Lys Ser Val 
    1970                1975                1980


Tyr Ile Thr Asn Phe Leu Leu Asn Gln Leu Asn Lys Glu Ile Tyr Lys 
1985                1990                1995                2000


Pro Leu Leu Ile Asn Phe Ser Ala Gln Thr Thr Ala Ala Gln Thr Gln 
                2005                2010                2015


Asn Ile Val Met Ser Lys Leu Asp Lys Arg Arg Lys Gly Val Phe Gly 
            2020                2025                2030


Pro Pro Leu Gly Lys Arg Met Val Val Phe Val Asp Asp Val Asn Met 
        2035                2040                2045


Pro Ala Arg Glu Val Tyr Gly Ala Gln Pro Pro Ile Glu Leu Leu Arg 
    2050                2055                2060


Gln Trp Leu Asp His Trp Asn Trp Tyr Asp Leu Lys Asp Cys Ser Met 
2065                2070                2075                2080


Ile Lys Leu Val Asp Ile Gln Ile Met Cys Ala Met Gly Pro Pro Gly 
                2085                2090                2095


Gly Gly Arg Asn Pro Val Thr Pro Arg Tyr Met Arg His Phe Asn Ile 
            2100                2105                2110


Ile Thr Ile Asn Glu Phe Ser Asp Lys Ser Met Tyr Thr Ile Phe Ser 
        2115                2120                2125


Arg Ile Leu Thr Trp His Leu Glu Ile Cys Tyr Lys Phe Pro Asp Glu 
    2130                2135                2140


Phe Leu Asp Leu Thr Thr Gln Ile Val Asn Gly Thr Met Thr Leu Tyr 
2145                2150                2155                2160


Lys Glu Ala Met Lys Asn Leu Leu Pro Thr Pro Ala Lys Ser His Tyr 
                2165                2170                2175


Leu Phe Asn Leu Arg Asp Phe Ser Arg Val Ile Gln Gly Val Cys Leu 
            2180                2185                2190


Ser Arg Pro Glu Thr Thr Glu Thr Thr Glu Val Ile Lys Arg Leu Trp 
        2195                2200                2205


Val His Glu Val Leu Arg Val Tyr Tyr Asp Arg Leu Leu Asp Asn Thr 
    2210                2215                2220


Asp Arg Ser Trp Leu Ile Asn Tyr Ile Gln Glu Ile Leu Arg Asn Tyr 
2225                2230                2235                2240


Met Tyr Glu Asp Phe His Glu Leu Phe Gln Arg Leu Asp Phe Asp Asn 
                2245                2250                2255


Asp Gly Met Val Glu Ala Asp Asp Leu Arg Ser Leu Met Phe Cys Asp 
            2260                2265                2270


Phe His Asp Pro Lys Arg Glu Asp Thr Asn Tyr Arg Glu Ile Ala Asp 
        2275                2280                2285


Val Asp Asn Leu Arg Met Ile Val Glu Ile His Leu Glu Glu Tyr Asn 
    2290                2295                2300


Asn Ile Ser Lys Lys Pro Met Asn Leu Val Leu Phe Arg Phe Ala Ile 
2305                2310                2315                2320


Glu His Ile Ser Arg Ile Ser Arg Ile Leu Lys Gln Pro Arg Ser His 
                2325                2330                2335


Ala Leu Leu Val Gly Val Gly Gly Ser Gly Arg Gln Ser Val Thr Arg 
            2340                2345                2350


Leu Ala Ala His Met Ala Asp Tyr Ser Val Phe Gln Val Glu Ile Ser 
        2355                2360                2365


Lys Gly Tyr Asp Thr Thr Glu Trp His Glu Asp Leu Lys Val Ile Leu 
    2370                2375                2380


Arg Lys Cys Ala Glu Gly Glu Met Gln Gly Val Phe Leu Phe Thr Asp 
2385                2390                2395                2400


Thr Gln Ile Lys Glu Glu Ser Phe Leu Glu Asp Val Ser Asn Leu Leu 
                2405                2410                2415


Asn Ala Gly Glu Ile Pro Asn Leu Phe Ala Leu Asp Glu Lys Gln Glu 
            2420                2425                2430


Ile Cys Asp Lys Met Arg Gln Leu Asp Arg Gln Arg Asp Lys Thr Lys 
        2435                2440                2445


Gln Thr Asp Gly Ser Pro Ile Ala Leu Phe Asn Met Phe Ile Asp His 
    2450                2455                2460


Cys Arg Ser Gln Leu His Val Val Leu Ala Met Ser Pro Ile Gly Asp 
2465                2470                2475                2480


Ala Phe Arg Asn Arg Leu Arg Lys Phe Pro Ala Leu Val Asn Cys Cys 
                2485                2490                2495


Thr Ile Asp Trp Phe Gln Ser Trp Pro Glu Asp Ala Leu Gln Ala Val 
            2500                2505                2510


Ala Ser Arg Phe Leu Glu Glu Ile Glu Met Ser Glu Glu Ile Arg Asp 
        2515                2520                2525


Gly Cys Ile Asp Met Cys Lys Ser Phe His Thr Ser Thr Ile Asp Leu 
    2530                2535                2540


Ser Lys Ser Phe Phe Val Glu Leu Gln Arg Tyr Asn Tyr Val Thr Pro 
2545                2550                2555                2560


Thr Ser Tyr Leu Glu Leu Ile Ser Thr Phe Lys Leu Leu Leu Glu Lys 
                2565                2570                2575


Lys Arg Ser Glu Val Met Lys Met Lys Lys Arg Tyr Glu Val Gly Leu 
            2580                2585                2590


Glu Lys Leu Asp Ser Ala Ser Ser Gln Val Ala Thr Met Gln Met Glu 
        2595                2600                2605


Leu Glu Ala Leu His Pro Gln Leu Lys Val Ala Ser Lys Glu Val Asp 
    2610                2615                2620


Glu Met Met Ile Met Ile Glu Lys Glu Ser Val Glu Val Ala Lys Thr 
2625                2630                2635                2640


Glu Lys Ile Val Lys Ala Asp Glu Thr Ile Ala Asn Glu Gln Ala Met 
                2645                2650                2655


Ala Ser Lys Ala Ile Lys Asp Glu Cys Asp Ala Asp Leu Ala Gly Ala 
            2660                2665                2670


Leu Pro Ile Leu Glu Ser Ala Leu Ala Ala Leu Asp Thr Leu Thr Ala 
        2675                2680                2685


Gln Asp Ile Thr Val Val Lys Ser Met Lys Ser Pro Pro Ala Gly Val 
    2690                2695                2700


Lys Leu Val Met Glu Ala Ile Cys Ile Leu Lys Gly Ile Lys Ala Asp 
2705                2710                2715                2720


Lys Ile Pro Asp Pro Thr Gly Ser Gly Lys Lys Ile Glu Asp Phe Trp 
                2725                2730                2735


Gly Pro Ala Lys Arg Leu Leu Gly Asp Met Arg Phe Leu Gln Ser Leu 
            2740                2745                2750


His Glu Tyr Asp Lys Asp Asn Ile Pro Pro Ala Tyr Met Asn Ile Ile 
        2755                2760                2765


Arg Lys Asn Tyr Ile Pro Asn Pro Asp Phe Val Pro Glu Lys Ile Arg 
    2770                2775                2780


Asn Ala Ser Thr Ala Ala Glu Gly Leu Cys Lys Trp Val Ile Ala Met 
2785                2790                2795                2800


Asp Ser Tyr Asp Lys Val Ala Lys Ile Val Ala Pro Lys Lys Ile Lys 
                2805                2810                2815


Leu Ala Ala Ala Glu Gly Glu Leu Lys Ile Ala Met Asp Gly Leu Arg 
            2820                2825                2830


Lys Lys Gln Ala Ala Leu Lys Glu Val Gln Asp Lys Leu Ala Arg Leu 
        2835                2840                2845


Gln Asp Thr Leu Glu Leu Asn Lys Gln Lys Lys Ala Asp Leu Glu Asn 
    2850                2855                2860


Gln Val Asp Leu Cys Ser Lys Lys Leu Glu Arg Ala Glu Gln Leu Ile 
2865                2870                2875                2880


Gly Gly Leu Gly Gly Glu Lys Thr Arg Trp Ser His Thr Ala Leu Glu 
                2885                2890                2895


Leu Gly Gln Leu Tyr Ile Asn Leu Thr Gly Asp Ile Leu Ile Ser Ser 
            2900                2905                2910


Gly Val Val Ala Tyr Leu Gly Ala Phe Thr Ser Thr Tyr Arg Gln Asn 
        2915                2920                2925


Gln Thr Lys Glu Trp Thr Thr Leu Cys Lys Gly Arg Asp Ile Pro Cys 
    2930                2935                2940


Ser Asp Asp Cys Ser Leu Met Gly Thr Leu Gly Glu Ala Val Thr Ile 
2945                2950                2955                2960


Arg Thr Trp Asn Ile Ala Gly Leu Pro Ser Asp Ser Phe Ser Ile Asp 
                2965                2970                2975


Asn Gly Ile Ile Ile Met Asn Ala Arg Arg Trp Pro Leu Met Ile Asp 
            2980                2985                2990


Pro Gln Ser Gln Ala Asn Lys Trp Ile Lys Asn Met Glu Lys Ala Asn 
        2995                3000                3005


Ser Leu Tyr Val Ile Lys Leu Ser Glu Pro Asp Tyr Val Arg Thr Leu 
    3010                3015                3020


Glu Asn Cys Ile Gln Phe Gly Thr Pro Val Leu Leu Glu Asn Val Gly 
3025                3030                3035                3040


Glu Glu Leu Asp Pro Ile Leu Glu Pro Leu Leu Leu Lys Gln Thr Phe 
                3045                3050                3055


Lys Gln Gly Gly Ser Thr Cys Ile Arg Leu Gly Asp Ser Thr Ile Glu 
            3060                3065                3070


Tyr Ala Pro Asp Phe Arg Phe Tyr Ile Thr Thr Lys Leu Arg Asn Pro 
        3075                3080                3085


His Tyr Leu Pro Glu Thr Ser Val Lys Val Thr Leu Leu Asn Phe Met 
    3090                3095                3100


Ile Thr Pro Glu Gly Met Gln Asp Gln Leu Leu Gly Ile Val Val Ala 
3105                3110                3115                3120


Gln Glu Arg Pro Asp Leu Glu Glu Glu Lys Gln Ala Leu Ile Leu Gln 
                3125                3130                3135


Gly Ala Glu Asn Lys Arg Gln Leu Lys Glu Ile Glu Asp Lys Ile Leu 
            3140                3145                3150


Glu Val Leu Ser Ser Ser Glu Gly Asn Ile Leu Glu Asp Glu Thr Ala 
        3155                3160                3165


Ile Lys Ile Leu Ser Ser Ser Lys Ala Leu Ala Asn Glu Ile Ser Gln 
    3170                3175                3180


Lys Gln Glu Val Ala Glu Glu Thr Glu Lys Lys Ile Asp Thr Thr Arg 
3185                3190                3195                3200


Met Gly Tyr Arg Pro Ile Ala Ile His Ser Ser Ile Leu Phe Phe Ser 
                3205                3210                3215


Leu Ala Asp Leu Ala Asn Ile Glu Pro Met Tyr Gln Tyr Ser Leu Thr 
            3220                3225                3230


Trp Phe Ile Asn Leu Phe Ile Leu Ser Ile Glu Asn Ser Glu Lys Ser 
        3235                3240                3245


Glu Ile Leu Ala Lys Arg Leu Gln Ile Leu Lys Asp His Phe Thr Tyr 
    3250                3255                3260


Ser Leu Tyr Val Asn Val Cys Arg Ser Leu Phe Glu Lys Asp Lys Leu 
3265                3270                3275                3280


Leu Phe Ser Phe Cys Leu Thr Ile Asn Leu Leu Leu His Glu Arg Ala 
                3285                3290                3295


Ile Asn Lys Ala Glu Trp Arg Phe Leu Leu Thr Gly Gly Ile Gly Leu 
            3300                3305                3310


Asp Asn Pro Tyr Ala Asn Leu Cys Thr Trp Leu Pro Gln Lys Ser Trp 
        3315                3320                3325


Asp Glu Ile Cys Arg Leu Asp Asp Leu Pro Ala Phe Lys Thr Ile Arg 
    3330                3335                3340


Arg Glu Phe Met Arg Leu Lys Asp Gly Trp Lys Lys Val Tyr Asp Ser 
3345                3350                3355                3360


Leu Glu Pro His His Glu Val Phe Pro Glu Glu Trp Glu Asp Lys Ala 
                3365                3370                3375


Asn Glu Phe Gln Arg Met Leu Ile Ile Arg Cys Leu Arg Pro Asp Lys 
            3380                3385                3390


Val Ile Pro Met Leu Gln Glu Phe Ile Ile Asn Arg Leu Gly Arg Ala 
        3395                3400                3405


Phe Ile Glu Pro Pro Pro Phe Asp Leu Ala Lys Ala Phe Gly Asp Ser 
    3410                3415                3420


Asn Cys Cys Ala Pro Leu Ile Phe Val Leu Ser Pro Gly Ala Asp Pro 
3425                3430                3435                3440


Met Ala Ala Leu Leu Lys Phe Ala Asp Asp Gln Gly Tyr Gly Gly Ser 
                3445                3450                3455


Lys Leu Ser Ser Leu Ser Leu Gly Gln Gly Gln Gly Pro Ile Ala Met 
            3460                3465                3470


Lys Met Leu Glu Lys Ala Val Lys Glu Gly Thr Trp Val Val Leu Gln 
        3475                3480                3485


Asn Cys His Leu Ala Thr Ser Trp Met Pro Thr Leu Glu Lys Val Cys 
    3490                3495                3500


Glu Glu Leu Ser Pro Glu Ser Thr His Pro Asp Phe Arg Met Trp Leu 
3505                3510                3515                3520


Thr Ser Tyr Pro Ser Pro Asn Phe Pro Val Ser Val Leu Gln Asn Gly 
                3525                3530                3535


Val Lys Met Thr Asn Glu Ala Pro Lys Gly Leu Arg Ala Asn Ile Ile 
            3540                3545                3550


Arg Ser Tyr Leu Met Asp Pro Ile Ser Asp Pro Glu Phe Phe Gly Ser 
        3555                3560                3565


Cys Lys Lys Pro Glu Glu Phe Lys Lys Leu Leu Tyr Gly Leu Cys Phe 
    3570                3575                3580


Phe His Ala Leu Val Gln Glu Arg Arg Lys Phe Gly Pro Leu Gly Trp 
3585                3590                3595                3600


Asn Ile Pro Tyr Glu Phe Asn Glu Thr Asp Leu Arg Ile Ser Val Gln 
                3605                3610                3615


Gln Leu His Met Phe Leu Asn Gln Tyr Glu Glu Leu Pro Tyr Glu Ala 
            3620                3625                3630


Leu Arg Tyr Met Thr Gly Glu Cys Asn Tyr Gly Gly Arg Val Thr Asp 
        3635                3640                3645


Asp Trp Asp Arg Arg Thr Leu Arg Ser Ile Leu Asn Lys Phe Phe Asn 
    3650                3655                3660


Pro Glu Leu Val Glu Asn Ser Asp Tyr Lys Phe Asp Ser Ser Gly Ile 
3665                3670                3675                3680


Tyr Phe Val Pro Pro Ser Gly Asp His Lys Ser Tyr Ile Glu Tyr Thr 
                3685                3690                3695


Lys Thr Leu Pro Leu Thr Pro Ala Pro Glu Ile Phe Gly Met Asn Ala 
            3700                3705                3710


Asn Ala Asp Ile Thr Lys Asp Gln Ser Glu Thr Gln Leu Leu Phe Asp 
        3715                3720                3725


Asn Ile Leu Leu Thr Gln Ser Arg Ser Ala Gly Ala Gly Ala Lys Ser 
    3730                3735                3740


Ser Asp Glu Val Val Asn Glu Val Ala Ser Asp Ile Leu Gly Lys Leu 
3745                3750                3755                3760


Pro Asn Asn Phe Asp Ile Glu Ala Ala Met Arg Arg Tyr Pro Thr Thr 
                3765                3770                3775


Tyr Thr Gln Ser Met Asn Thr Val Leu Val Gln Glu Met Gly Arg Phe 
            3780                3785                3790


Asn Lys Leu Leu Lys Thr Ile Arg Asp Ser Cys Val Asn Ile Gln Lys 
        3795                3800                3805


Ala Ile Lys Gly Leu Ala Val Met Ser Thr Asp Leu Glu Glu Val Val 
    3810                3815                3820


Ser Ser Ile Leu Asn Val Lys Ile Pro Glu Met Trp Met Gly Lys Ser 
3825                3830                3835                3840


Tyr Pro Ser Leu Lys Pro Leu Gly Ser Tyr Val Asn Asp Phe Leu Ala 
                3845                3850                3855


Arg Leu Lys Phe Leu Gln Gln Trp Tyr Glu Val Gly Pro Pro Pro Val 
            3860                3865                3870


Phe Trp Leu Ser Gly Phe Phe Phe Thr Gln Ala Phe Leu Thr Gly Ala 
        3875                3880                3885


Gln Gln Asn Tyr Ala Arg Lys Tyr Thr Ile Pro Ile Asp Leu Leu Gly 
    3890                3895                3900


Phe Asp Tyr Glu Val Met Glu Asp Lys Glu Tyr Lys His Pro Pro Glu 
3905                3910                3915                3920


Asp Gly Val Phe Ile His Gly Leu Phe Leu Asp Gly Ala Ser Trp Asn 
                3925                3930                3935


Arg Lys Ile Lys Lys Leu Ala Glu Ser His Pro Lys Ile Leu Tyr Asp 
            3940                3945                3950


Thr Val Pro Val Met Trp Leu Lys Pro Cys Lys Arg Ala Asp Ile Pro 
        3955                3960                3965


Lys Arg Pro Ser Tyr Val Ala Pro Leu Tyr Lys Thr Ser Glu Arg Arg 
    3970                3975                3980


Gly Val Leu Ser Thr Thr Gly His Ser Thr Asn Phe Val Ile Ala Met 
3985                3990                3995                4000


Thr Leu Pro Ser Asp Gln Pro Lys Glu His Trp Ile Gly Arg Gly Val 
                4005                4010                4015


Ala Leu Leu Cys Gln Leu Asn Ser 
            4020


<210>  193
<211>  1707
<212>  DNA
<213>  Homo sapiens

<400>  193
ctctccgctg ctgtcgccag gagtcacttc acgagaagcc aggtcacaac cgtcggccct     60

tgtctggaaa agtaaaagtg gatcctgcca cgttcggagc tccctggcgc ctcgcccggc    120

tggagctaga gaactcgtcc tgtggcggcc cccggcgtgg ggcgggacag cggccccctg    180

gagggggcag tcccgggaga acctgcggcg gccggagcgg taaaaataag tgactaaaga    240

agcagacctg ggaatcacct aacatgtcga ggaggagatt tgattgccga agtatttcag    300

gcctactaac tacaactcct caaattccaa taaaaatgga aaactttaat aatttctata    360

tacttacatc taaagagcta gggagaggta aatttgctgt ggttagacaa tgtatatcaa    420

aatctactgg ccaagaatat gctgcaaaat ttctaaaaaa gagaagaaga ggacaggatt    480

gtcgggcaga aattttacac gagattgctg tgcttgaatt ggcaaagtct tgtccccgtg    540

ttattaatct tcatgaggtc tatgaaaata caagtgaaat cattttgata ttggaatatg    600

ctgcaggtgg agaaattttc agcctgtgtt tacctgagtt ggctgaaatg gtttctgaaa    660

atgatgttat cagactcatt aaacaaatac ttgaaggagt ttattatcta catcagaata    720

acattgtaca ccttgattta aagccacaga atatattact gagcagcata taccctctcg    780

gggacattaa aatagtagat tttggaatgt ctcgaaaaat agggcatgcg tgtgaacttc    840

gggaaatcat gggaacacca gaatatttag ctccagaaat cctgaactat gatcccatta    900

ccacagcaac agatatgtgg aatattggta taatagcata tatgttgtta actcacacat    960

caccatttgt gggagaagat aatcaagaaa catacctcaa tatctctcaa gttaatgtag   1020

attattcgga agaaactttt tcatcagttt cacagctggc cacagacttt attcagagcc   1080

ttttagtaaa aaatccagag aaaagaccaa cagcagagat atgcctttct cattcttggc   1140

tacagcagtg ggactttgaa aacttgtttc accctgaaga aacttccagt tcctctcaaa   1200

ctcaggatca ttctgtaagg tcctctgaag acaagacttc taaatcctcc tgtaatggaa   1260

cctgtggtga tagagaagac aaagagaata tcccagagga tagcagcatg gtttccaaaa   1320

gatttcgttt cgatgactca ttacccaatc cccatgaact tgtttcagat ttgctctgtt   1380

agcacttttt tctttgactc atttggactg aatttgaaat tttatatcca ctccagtgag   1440

attatgattt gtagcttcat atatgacatg tttatattgt aaatgcactt ttccatggaa   1500

taatttaggg aagtgtttta atgttaaatt actagttgct agcatgttat gatttcatat   1560

cctgagatag ctctgcagat aagaaaatat ttaaatatat gacaaaaagt aaaattgtac   1620

atgtgagttt acatgttaat gaaataattc aacttcaaat gaacttacca gaatgttttg   1680

catatcaaca aaaaaaaaaa aaaaaaa                                       1707


<210>  194
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  194

Met Ser Arg Arg Arg Phe Asp Cys Arg Ser Ile Ser Gly Leu Leu Thr 
1               5                   10                  15


Thr Thr Pro Gln Ile Pro Ile Lys Met Glu Asn Phe Asn Asn Phe Tyr 
            20                  25                  30


Ile Leu Thr Ser Lys Glu Leu Gly Arg Gly Lys Phe Ala Val Val Arg 
        35                  40                  45


Gln Cys Ile Ser Lys Ser Thr Gly Gln Glu Tyr Ala Ala Lys Phe Leu 
    50                  55                  60


Lys Lys Arg Arg Arg Gly Gln Asp Cys Arg Ala Glu Ile Leu His Glu 
65                  70                  75                  80


Ile Ala Val Leu Glu Leu Ala Lys Ser Cys Pro Arg Val Ile Asn Leu 
                85                  90                  95


His Glu Val Tyr Glu Asn Thr Ser Glu Ile Ile Leu Ile Leu Glu Tyr 
            100                 105                 110


Ala Ala Gly Gly Glu Ile Phe Ser Leu Cys Leu Pro Glu Leu Ala Glu 
        115                 120                 125


Met Val Ser Glu Asn Asp Val Ile Arg Leu Ile Lys Gln Ile Leu Glu 
    130                 135                 140


Gly Val Tyr Tyr Leu His Gln Asn Asn Ile Val His Leu Asp Leu Lys 
145                 150                 155                 160


Pro Gln Asn Ile Leu Leu Ser Ser Ile Tyr Pro Leu Gly Asp Ile Lys 
                165                 170                 175


Ile Val Asp Phe Gly Met Ser Arg Lys Ile Gly His Ala Cys Glu Leu 
            180                 185                 190


Arg Glu Ile Met Gly Thr Pro Glu Tyr Leu Ala Pro Glu Ile Leu Asn 
        195                 200                 205


Tyr Asp Pro Ile Thr Thr Ala Thr Asp Met Trp Asn Ile Gly Ile Ile 
    210                 215                 220


Ala Tyr Met Leu Leu Thr His Thr Ser Pro Phe Val Gly Glu Asp Asn 
225                 230                 235                 240


Gln Glu Thr Tyr Leu Asn Ile Ser Gln Val Asn Val Asp Tyr Ser Glu 
                245                 250                 255


Glu Thr Phe Ser Ser Val Ser Gln Leu Ala Thr Asp Phe Ile Gln Ser 
            260                 265                 270


Leu Leu Val Lys Asn Pro Glu Lys Arg Pro Thr Ala Glu Ile Cys Leu 
        275                 280                 285


Ser His Ser Trp Leu Gln Gln Trp Asp Phe Glu Asn Leu Phe His Pro 
    290                 295                 300


Glu Glu Thr Ser Ser Ser Ser Gln Thr Gln Asp His Ser Val Arg Ser 
305                 310                 315                 320


Ser Glu Asp Lys Thr Ser Lys Ser Ser Cys Asn Gly Thr Cys Gly Asp 
                325                 330                 335


Arg Glu Asp Lys Glu Asn Ile Pro Glu Asp Ser Ser Met Val Ser Lys 
            340                 345                 350


Arg Phe Arg Phe Asp Asp Ser Leu Pro Asn Pro His Glu Leu Val Ser 
        355                 360                 365


Asp Leu Leu Cys 
    370


<210>  195
<211>  716
<212>  DNA
<213>  Homo sapiens

<400>  195
atggcttctt ggtggcagag aatggggacc tccgtgcacc ggagatgtct ccagcaccag     60

gagcagctgg aggatgcaag gagctgcagc ccgtgaccag ccatcaggag aactccgcgg    120

gtccctgggg tccctgtgca gacagttcca atggaggctg cctctgagag ccatcaacct    180

caacttccgt gcaggccctt cctgcaaatg cttggaaacc ccagagccag ggcagcaggg    240

cctccaggct acggctcact cagctaagag tgccttgggt gccatgtccc agagaatcca    300

ggagtcctgc caaagtggca ccaagtggct ggtggagacc caggtgaagg ccaggaggag    360

gaagagacgg gcacagaagg gcagtggctc cccagctcac agcctgagcc agaagagcac    420

ccggctatct ggagatgccc ctgcccactc agcccacaga cccctgggag aaggagcata    480

actgcctctc cgcccggata ggctcccatg cctacccatt atgacagtcg atgcaggagg    540

ctgccttctg gagcccctac tcctcaacag agccactctg ctctcccagc cagtctggca    600

gtgacctaga gcctatgggg gtgggaattc agcatctcca gaagctgtcc caagagctag    660

atgaagccat tatggcggaa gagagtggtg acatcatctc tctcattcat ggctga        716


<210>  196
<211>  2175
<212>  DNA
<213>  Homo sapiens

<400>  196
atgggcctga agcttccctt ttctcctgcc tgcctgccag cccgcccctc aagctctggg     60

gagacagggc gggcctcagc agatgcccca gaagatgcca gctgcctccc ttacgacagc    120

ccctcaggtt gcttcctctc cacccttttg ttaaagggcc tgaccttcag gcgagagttg    180

gtggccaaga tgagcttcca tgcagccgca gcactgatga aaggctgctc gattagggat    240

ggcaccttgc gctgggcaca gcgtcgaagc ttcactccag ccagctttct ggcggaaaac    300

acgaatttcc ctgatgagat ggacacatcc ttctttgccc aggaaggtat cctccatgaa    360

gagctgtcca catacccgga cgaagttttt gagtccccat cagaggcagc actcaaggac    420

tgggagaagg caccggagca ggagtacctc actggcaggg ccctggaccg cagtgagctt    480

gagcccagcc acctgatgct gcctttggag cgaggctggc ggaagcggga agacaccgca    540

gcctcgcagc ccaaggtgcg gctccgacag gagatggtga gcaccgcggg gccgcggcgg    600

aaccagcgca tcgctgtgcc ggtgcgcaaa ctcttcgccc gggagaagcg gctgtatggg    660

ctgagcatgg tgggacggct caacaaccac acctaccaca agcacatcga cagcttcgtc    720

aagcgacaga tcgaggacat ggacagccac aggcccttct tcacccactg gctcaccttc    780

gtgcacttgc tcgtcaccat tctagccgtg tgcatctatg gcatcgtgcc cgtggacttc    840

tcacagcatg aaacgatgga ctcgattctg tggaaccact gggtctacga gaacgtcaag    900

tacgtgcagc aggagaactt ctggatcggg cccagctcgg aggccctcat ccacctgggt    960

gccaagtttt cgccttgcat atgccaggat ccgcaggtgc acagcttcat tcgcgcaggg   1020

cgcgagcacg agaagcactc ggcctgctgc atgcacaacg acaggtcggg ctgcctgcag   1080

acctcggagg aggagtgctc gcccatgctg gcaatgtggg tgaagtgacc catccattcc   1140

agcgccccag agcttgccgg ccacaagaga cagtttggct ctgtctgcca ccaggatccc   1200

agggtatatg atgagccctc ttgggaggac ccccgtgagt ggccagaaga cattaccaag   1260

tggccgatct gcaccagaaa caaccccggg aaccacacca accttcccca catggactgt   1320

gtcatcacag gacggccctg ctgcattggc accaacggcg agtgtgagat cacctcccgg   1380

gagtactgtg acttcatgag gggctatttc catgaggagg ccatgctctg ctctcaggtg   1440

cactgcatgg atgatgtgtg tgggctcctg cctttcctca accctgaggt gcctgaccag   1500

ttctaccgcc tgtggctgtc cctcttcctg cacaccagga tcctgcacta cctggtgtcc   1560

atctgcttcc agatgaccat cccgcgggac ctggagaagc tggcagggtg gcaccacata   1620

gccatcatct acctgctgag tggtgtcact ggcaacctgg ccagtgccat cttcctgctg   1680

taccgagcag aggtggttcc agctggctcc cagtttggca tcctggcctg cctcttcatg   1740

gagctcttcc agagctggca gatcctggag cggccctggc atgccttctt caagctgctg   1800

gctgtggtgc tcttcctctg cacctttggg ctgctgccct ggatcgacaa ctttgcccac   1860

atttcggggt tcatcagtgg cctctttctc tccttcgcct tctagcgcta catcagcttc   1920

agcaagttcc atctgtactg gaaatgctgc ctgatcatca tctttcaggt ggtcttcctg   1980

ggcctcctgg ctggcctggt ggtcctcttc tacttctatc ctgtctgccg tgagtggtgt   2040

gagttcctca cctgcatccc cttcactgat aatttctgcg agaagtacga actggatgct   2100

cagctccacc gagctggctg cgggctccag ggaccatgcg ctccagcagg ccagagccag   2160

acacgacaac cctga                                                    2175


<210>  197
<211>  957
<212>  DNA
<213>  Homo sapiens

<400>  197
atgtgcacag tctgcggggc ctcgaagtca gccattatgc cccccaaagt gagcagcggc     60

agtggcagga cccaggcgcg ggtcctcctt cctcctcccg ccccctcgcg gtcagacaac    120

aggtacgcgg ggagcagccc gggcggcccc gcgcaggggt tgagccgcag cgctgctgtg    180

caggggcagg cccgggcagg gggcagtgcg gcgagaaagt tgggtgcgac ggaccgcagc    240

ctcgggggcc aaaggacccc caccgtgagc gcggccacct cccgacaccc ggcgggctgg    300

ctggagggag caggtgaggc acgtggccgc ctcgccaagc cagggctccc tccaggagcc    360

cgacccgccg gccgggccgg tggatgcccc ctcgagggct cagacccttc gctccagccc    420

ccggcgggcg ccctgccccg ggtcccacac tcccgcgccc cgtgggcccc actgctggct    480

ttccgggacc aggctccgct ccgcagctcg cgtcctgagg tgatcctcca ggctccccac    540

tttgggaccc cctcctgcgc ctcgggtgcc ggcgcctgtc ttcgcctccc gcggggaccc    600

tccccggcgc cccaggcgtg tgcgccccgg gccagctcag ctctgggtcc gccctccgca    660

ccccgcgccg cgcgcgcgct caccggccgg gcagcggccg cgtcttacct tcgtccggca    720

gccgctgcag gcagagcgcg aggttcctcc gccagccccg catccccgcg gccgccctgc    780

ggcccggccc ggcctcgcca gcccggcccc ggccccgccc ccgccgggca gggcggcgca    840

gcgcagcgct ggggagggcc gcgggcccag ggagccgcgg gcatggacgg ccgccgaggg    900

tgggggtgcc ggggcggccg ccaggcgctc cgctccggct cccgagcccg cggctga       957


<210>  198
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  198

Met Cys Thr Val Cys Gly Ala Ser Lys Ser Ala Ile Met Pro Pro Lys 
1               5                   10                  15


Val Ser Ser Gly Ser Gly Arg Thr Gln Ala Arg Val Leu Leu Pro Pro 
            20                  25                  30


Pro Ala Pro Ser Arg Ser Asp Asn Arg Tyr Ala Gly Ser Ser Pro Gly 
        35                  40                  45


Gly Pro Ala Gln Gly Leu Ser Arg Ser Ala Ala Val Gln Gly Gln Ala 
    50                  55                  60


Arg Ala Gly Gly Ser Ala Ala Arg Lys Leu Gly Ala Thr Asp Arg Ser 
65                  70                  75                  80


Leu Gly Gly Gln Arg Thr Pro Thr Val Ser Ala Ala Thr Ser Arg His 
                85                  90                  95


Pro Ala Gly Trp Leu Glu Gly Ala Gly Glu Ala Arg Gly Arg Leu Ala 
            100                 105                 110


Lys Pro Gly Leu Pro Pro Gly Ala Arg Pro Ala Gly Arg Ala Gly Gly 
        115                 120                 125


Cys Pro Leu Glu Gly Ser Asp Pro Ser Leu Gln Pro Pro Ala Gly Ala 
    130                 135                 140


Leu Pro Arg Val Pro His Ser Arg Ala Pro Trp Ala Pro Leu Leu Ala 
145                 150                 155                 160


Phe Arg Asp Gln Ala Pro Leu Arg Ser Ser Arg Pro Glu Val Ile Leu 
                165                 170                 175


Gln Ala Pro His Phe Gly Thr Pro Ser Cys Ala Ser Gly Ala Gly Ala 
            180                 185                 190


Cys Leu Arg Leu Pro Arg Gly Pro Ser Pro Ala Pro Gln Ala Cys Ala 
        195                 200                 205


Pro Arg Ala Ser Ser Ala Leu Gly Pro Pro Ser Ala Pro Arg Ala Ala 
    210                 215                 220


Arg Ala Leu Thr Gly Arg Ala Ala Ala Ala Ser Tyr Leu Arg Pro Ala 
225                 230                 235                 240


Ala Ala Ala Gly Arg Ala Arg Gly Ser Ser Ala Ser Pro Ala Ser Pro 
                245                 250                 255


Arg Pro Pro Cys Gly Pro Ala Arg Pro Arg Gln Pro Gly Pro Gly Pro 
            260                 265                 270


Ala Pro Ala Gly Gln Gly Gly Ala Ala Gln Arg Trp Gly Gly Pro Arg 
        275                 280                 285


Ala Gln Gly Ala Ala Gly Met Asp Gly Arg Arg Gly Trp Gly Cys Arg 
    290                 295                 300


Gly Gly Arg Gln Ala Leu Arg Ser Gly Ser Arg Ala Arg Gly 
305                 310                 315


<210>  199
<211>  2975
<212>  DNA
<213>  Homo sapiens

<400>  199
gaagacactt ccggttgcga cggaggtagg cttacgaggc ctgtgtcggg tagaaagggt     60

ccttcctgga ccgggaccct ctgccacgac catggaccgt aggaaaaagc ctttggacgt    120

cacggcctcc tcgttggtag atcttaaggc tgaactcttc cgaaagcaag aagaattcaa    180

acaagaaaaa cttctaaaag attctggagt ttttggaaaa ccaaaaacaa ctaacaagaa    240

accaagtatc tggagcaaac agaatgtagg cgtttcaaat cgagctgaga aggatgctga    300

acagaagatt gaagaacaga agactttaga caaagcaagg gaaaaattgg aagaaaaagc    360

caaattatat gaaaaaatga ctaaaggaga ctttatagat gaagaagtag aggatatgta    420

ccttgtggat ttcacacaga agatcataga caagcgcaaa gaaatggagg catctggtgc    480

ccatagagat tctcaaaagg caggagaaag ggacgacgat gaggaaaacc ttcctgaggg    540

agagatccct cctccccaag accccagtga agaatgggtg gattacgtgg actctttggg    600

gcgttcccgg cgctgtatga gaaaggattt gccagatctg ctggagatgg ataaaaatct    660

tcaggggaga ctttttatta gtcctgctaa tgaaaaaacc ctattatctg aagatatgag    720

aaaagaactt cagcgccagc aatgggagga agaagaaaga gaggccctga agaggcccat    780

ggggcccgta cattatgaag acattcggga aaatgaggcc cggcaacttg gtgttgggta    840

ttttgccttt gcccgagaca aagagttgag aaacaagcag atgaaaacct tagagatgct    900

gcgtgaacag acaacagatc agagaacaaa acgagaaaac ataaaggaaa agcgaaaggc    960

tatcttagag gcaagacttg ccaaacttcg acaaaaaaag atgaaaaaat caaaagaagg   1020

tggaacagaa gaagaaaata gagatggaga tgttattggg cctttgccac cggagccaga   1080

ggctgtgcca accccacgtc ctgctgccca gagtagcaaa gtagaagtca ttgtccagga   1140

gaggaaggac accaagcctg gagtgccaca catccgggag tgggaccgcg gaaaagaatt   1200

ttcctttgga tactggtcga agaggcagtc agatctccgg gctgagagag atcctgagtt   1260

tgccccgccg tcagattact ttgtgggtca gaagagaact ggtttttcca gcagccaggc   1320

atggagcaga cctgggccag cacagagtga cccagggcag tgccctgacc agagccacgg   1380

acctagccct gaacatacgt cacccactcc tgcccccgac aacccaccac aagcccccac   1440

agttactttc aaaactctgg atgacatgat ttcctattac aaacaagtga catgatcttt   1500

caaagcacgc tgacttgggt ttgtactttg acagtgcctt tctctcccag agggagaaat   1560

aactttagga actgaattgt acctttgtcc tgtcctttcc ctaggaggca cagacttcgg   1620

gttggatttg tcagcaagga ggaaagttat ggaaactttg gccacttggc tgttcatttt   1680

attctaagtg ggatagggac atacctacct ggatttacat gtgagctgcg atagaataga   1740

agtatttatt ctgtaaaatt agacactgag atgtgcttat aaccctgttt catatctact   1800

cccacgactt actcatattt aagggttctt ttccattcct tttgcaaatc cgagcatgca   1860

ggtgtcttta ttccaagggt tcagcttcca gatcagccga tggaccatag gtcacgagga   1920

atttctccct gtcaagcagt ggaaaactgc atgggaggca aaatgctctg ttctccaaga   1980

ggacccggaa gtaatcacat aggaaatgat aaggaagacc aggaggagct cttcgtagtc   2040

cagaaaggta gaagtgggag ttgtttactt aattttactg tcataccatg ctattaccta   2100

cactcctgtg tgcagtgggc attcagtaaa tgtgtgttga aggactggga cgtacgtgga   2160

ggctgctgga cctggtcaga gactgatgtg ccttagcggc aatggttaga gcttttcagt   2220

gcatcccacc tccctgtcgc ccccatgctc ggcttcctca cattcaggag cctgacttgg   2280

atcagacttg gggctgcaca gtggagcagg tgggttcccg tgtcattagt aataaggaga   2340

gggttggggg tgggcagggc tccagaaagt cagcagtgtg cctgggcacc caccccatcc   2400

tctacctgcc acacctcaga gggttcctac agctgcacac aagcagttga gagttgatga   2460

ccaggcccat agggctccca cagctggttc ccaggccagt gagtgctgtg agaatacagt   2520

agcacaagtc cttgttctct gaagagtggg aaggagagga gtgagtgaag tagcctgtcc   2580

cctgcaggtc ctctgcgatg gcattgtctc ggttcccgca gtgctgcagt gtggaaggga   2640

gtgccccatc ctcattacag atgacacact ggagtgtgga ggggtcgatg acttgtgcag   2700

ggtcatatgg tacctaaggg gcagatctca gacttaaaca caattgatgt ctaaccccta   2760

gacagtcttt ttagtgccct ctgctctcag tcttgttgcc ctagtatcaa gcaatcttag   2820

acaaacatcc tgaattctta caaacttacc tctaaactct gaggataaag ttgccagtcc   2880

ttttaatggt cagcctaatc attctgtcag cctaatcggg taattgcttt ttttaataaa   2940

tacacataaa aaccaactaa aaaaaaaaaa aaaaa                              2975


<210>  200
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  200

Met Asp Arg Arg Lys Lys Pro Leu Asp Val Thr Ala Ser Ser Leu Val 
1               5                   10                  15


Asp Leu Lys Ala Glu Leu Phe Arg Lys Gln Glu Glu Phe Lys Gln Glu 
            20                  25                  30


Lys Leu Leu Lys Asp Ser Gly Val Phe Gly Lys Pro Lys Thr Thr Asn 
        35                  40                  45


Lys Lys Pro Ser Ile Trp Ser Lys Gln Asn Val Gly Val Ser Asn Arg 
    50                  55                  60


Ala Glu Lys Asp Ala Glu Gln Lys Ile Glu Glu Gln Lys Thr Leu Asp 
65                  70                  75                  80


Lys Ala Arg Glu Lys Leu Glu Glu Lys Ala Lys Leu Tyr Glu Lys Met 
                85                  90                  95


Thr Lys Gly Asp Phe Ile Asp Glu Glu Val Glu Asp Met Tyr Leu Val 
            100                 105                 110


Asp Phe Thr Gln Lys Ile Ile Asp Lys Arg Lys Glu Met Glu Ala Ser 
        115                 120                 125


Gly Ala His Arg Asp Ser Gln Lys Ala Gly Glu Arg Asp Asp Asp Glu 
    130                 135                 140


Glu Asn Leu Pro Glu Gly Glu Ile Pro Pro Pro Gln Asp Pro Ser Glu 
145                 150                 155                 160


Glu Trp Val Asp Tyr Val Asp Ser Leu Gly Arg Ser Arg Arg Cys Met 
                165                 170                 175


Arg Lys Asp Leu Pro Asp Leu Leu Glu Met Asp Lys Asn Leu Gln Gly 
            180                 185                 190


Arg Leu Phe Ile Ser Pro Ala Asn Glu Lys Thr Leu Leu Ser Glu Asp 
        195                 200                 205


Met Arg Lys Glu Leu Gln Arg Gln Gln Trp Glu Glu Glu Glu Arg Glu 
    210                 215                 220


Ala Leu Lys Arg Pro Met Gly Pro Val His Tyr Glu Asp Ile Arg Glu 
225                 230                 235                 240


Asn Glu Ala Arg Gln Leu Gly Val Gly Tyr Phe Ala Phe Ala Arg Asp 
                245                 250                 255


Lys Glu Leu Arg Asn Lys Gln Met Lys Thr Leu Glu Met Leu Arg Glu 
            260                 265                 270


Gln Thr Thr Asp Gln Arg Thr Lys Arg Glu Asn Ile Lys Glu Lys Arg 
        275                 280                 285


Lys Ala Ile Leu Glu Ala Arg Leu Ala Lys Leu Arg Gln Lys Lys Met 
    290                 295                 300


Lys Lys Ser Lys Glu Gly Gly Thr Glu Glu Glu Asn Arg Asp Gly Asp 
305                 310                 315                 320


Val Ile Gly Pro Leu Pro Pro Glu Pro Glu Ala Val Pro Thr Pro Arg 
                325                 330                 335


Pro Ala Ala Gln Ser Ser Lys Val Glu Val Ile Val Gln Glu Arg Lys 
            340                 345                 350


Asp Thr Lys Pro Gly Val Pro His Ile Arg Glu Trp Asp Arg Gly Lys 
        355                 360                 365


Glu Phe Ser Phe Gly Tyr Trp Ser Lys Arg Gln Ser Asp Leu Arg Ala 
    370                 375                 380


Glu Arg Asp Pro Glu Phe Ala Pro Pro Ser Asp Tyr Phe Val Gly Gln 
385                 390                 395                 400


Lys Arg Thr Gly Phe Ser Ser Ser Gln Ala Trp Ser Arg Pro Gly Pro 
                405                 410                 415


Ala Gln Ser Asp Pro Gly Gln Cys Pro Asp Gln Ser His Gly Pro Ser 
            420                 425                 430


Pro Glu His Thr Ser Pro Thr Pro Ala Pro Asp Asn Pro Pro Gln Ala 
        435                 440                 445


Pro Thr Val Thr Phe Lys Thr Leu Asp Asp Met Ile Ser Tyr Tyr Lys 
    450                 455                 460


Gln Val Thr 
465


<210>  201
<211>  1674
<212>  DNA
<213>  Homo sapiens

<400>  201
aaagcttccc gagagccatg gttggtccag gcaggcagtc ggagcacctc gtggagcggc     60

tgctaaccca gggtggggtg gggtggggtg gaggggtctg cttgtagtac tctcagtcct    120

gatgtcacag gcgcggcaag gacatcgcaa ggaggagtcg gattacagta aggatgggca    180

gtgcagcagg cagcccgagc gcactctcca gccgccgggg atcttagccc tggaaaggca    240

gcctgcaagg cgctcatccc gcggaggagg cacgctctcg gcgctcactg ctctccacgc    300

cggggacatt tccaccgaat gtagcatgaa agggctctgc tctacgtgcc agccttgggt    360

gagagctgat gctgaagaca ccgcggtggg attccagctg tctgattaat gagaaacata    420

atgtattttg gtggtacatg ccagagtcct gctctcccgg cccttgtccg tccaccagcc    480

cctcctttgc aaccatcgct ggatattaaa ccatttcttc cctttcctct tgacactgca    540

gctgcagtca acctcttccc caatttcaat gcgatggacc cgattcagaa agctgtaata    600

aaccatacat tcggggttcc tcttccccac cgaagaaagc aaatcatatc atgcaacatt    660

tgccagttga gatttaattc tgatagccag gctgcggccc actacaaagg cacgaaacat    720

gccaagaagc tcaaagcact ggaagccatg aaaaataagc agaaatctgt aactgccaag    780

gacagcgcaa agactacctt cacctccatc actaccaata ccatcaatac cagctctgac    840

aaaacagacg gtactgcagg gacaccagca atatcaacga cgacaactgt ggaaatccgc    900

aaaagcagtg ttatgacaac tgagatcacc tctaaagtgg aaaaaagccc aacgacagcc    960

actggcaata gctcatgtcc ttctactgag accgaggaag aaaaggcaaa acggcttctt   1020

tactgttcgc tatgcaaggt tgctgtcaac tctgcctcgc agctggaggc gcacaacagt   1080

ggtactaagc acaaaaccat gttagaagcc cggaatggaa gtggcactat caaagccttt   1140

cctagggcag gagtgaaagg caaaggacct gttaataaag gaaacacagg cctccaaaat   1200

aaaacatttc actgtgaaat ctgtgatgtg cacgtcaact cggaaacgca acttaaacag   1260

cacattagca gtagaaggca caaagacaga gctgctggga agcccccgaa acctaaatac   1320

agtccttaca acaaactaca gaagacagca catccactgg gggtaaaatt agtattttca   1380

aaagaacctt caaagccatt ggctccacga attctaccaa accctctagc agctgcagca   1440

gccgcagcag cagtggcagt gagttccccc ttcagtcttc gaactgctcc agcagcaaca   1500

ctgttccaga cttctgcgct tcctccggca ctcctgcggc cagctcccgg acccattcgg   1560

accgcccaca ctcctgtgct gtttgctcct tactaaattc caaataggag taattgtact   1620

gcaataattt ttcaaaaaac aaaaaacaaa acaaaaaaaa aaaaaaaaaa aaaa         1674


<210>  202
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  202

Met Arg Asn Ile Met Tyr Phe Gly Gly Thr Cys Gln Ser Pro Ala Leu 
1               5                   10                  15


Pro Ala Leu Val Arg Pro Pro Ala Pro Pro Leu Gln Pro Ser Leu Asp 
            20                  25                  30


Ile Lys Pro Phe Leu Pro Phe Pro Leu Asp Thr Ala Ala Ala Val Asn 
        35                  40                  45


Leu Phe Pro Asn Phe Asn Ala Met Asp Pro Ile Gln Lys Ala Val Ile 
    50                  55                  60


Asn His Thr Phe Gly Val Pro Leu Pro His Arg Arg Lys Gln Ile Ile 
65                  70                  75                  80


Ser Cys Asn Ile Cys Gln Leu Arg Phe Asn Ser Asp Ser Gln Ala Ala 
                85                  90                  95


Ala His Tyr Lys Gly Thr Lys His Ala Lys Lys Leu Lys Ala Leu Glu 
            100                 105                 110


Ala Met Lys Asn Lys Gln Lys Ser Val Thr Ala Lys Asp Ser Ala Lys 
        115                 120                 125


Thr Thr Phe Thr Ser Ile Thr Thr Asn Thr Ile Asn Thr Ser Ser Asp 
    130                 135                 140


Lys Thr Asp Gly Thr Ala Gly Thr Pro Ala Ile Ser Thr Thr Thr Thr 
145                 150                 155                 160


Val Glu Ile Arg Lys Ser Ser Val Met Thr Thr Glu Ile Thr Ser Lys 
                165                 170                 175


Val Glu Lys Ser Pro Thr Thr Ala Thr Gly Asn Ser Ser Cys Pro Ser 
            180                 185                 190


Thr Glu Thr Glu Glu Glu Lys Ala Lys Arg Leu Leu Tyr Cys Ser Leu 
        195                 200                 205


Cys Lys Val Ala Val Asn Ser Ala Ser Gln Leu Glu Ala His Asn Ser 
    210                 215                 220


Gly Thr Lys His Lys Thr Met Leu Glu Ala Arg Asn Gly Ser Gly Thr 
225                 230                 235                 240


Ile Lys Ala Phe Pro Arg Ala Gly Val Lys Gly Lys Gly Pro Val Asn 
                245                 250                 255


Lys Gly Asn Thr Gly Leu Gln Asn Lys Thr Phe His Cys Glu Ile Cys 
            260                 265                 270


Asp Val His Val Asn Ser Glu Thr Gln Leu Lys Gln His Ile Ser Ser 
        275                 280                 285


Arg Arg His Lys Asp Arg Ala Ala Gly Lys Pro Pro Lys Pro Lys Tyr 
    290                 295                 300


Ser Pro Tyr Asn Lys Leu Gln Lys Thr Ala His Pro Leu Gly Val Lys 
305                 310                 315                 320


Leu Val Phe Ser Lys Glu Pro Ser Lys Pro Leu Ala Pro Arg Ile Leu 
                325                 330                 335


Pro Asn Pro Leu Ala Ala Ala Ala Ala Ala Ala Ala Val Ala Val Ser 
            340                 345                 350


Ser Pro Phe Ser Leu Arg Thr Ala Pro Ala Ala Thr Leu Phe Gln Thr 
        355                 360                 365


Ser Ala Leu Pro Pro Ala Leu Leu Arg Pro Ala Pro Gly Pro Ile Arg 
    370                 375                 380


Thr Ala His Thr Pro Val Leu Phe Ala Pro Tyr 
385                 390                 395


<210>  203
<211>  3954
<212>  DNA
<213>  Homo sapiens

<400>  203
agggggaggt gggcagccgg ccagggaagc acggtccagg cggctacatt cggcccggcc     60

atggcagcgg cgcccctgaa agtgtgcatc gtgggctcgg ggaactgggg ttcagctgtt    120

gcaaaaataa ttggtaataa tgtcaagaaa cttcagaaat ttgcctccac agtcaagatg    180

tgggtctttg aagaaacagt gaatggcaga aaactgacag acatcataaa taatgaccat    240

gaaaatgtaa aatatcttcc tggacacaag ctgccagaaa atgtggttgc catgtcaaat    300

cttagcgagg ctgtgcagga tgcagacctg ctggtgtttg tcattcccca ccagttcatt    360

cacagaatct gtgatgagat cactgggaga gtgcccaaga aagcgctggg aatcaccctc    420

atcaagggca tagacgaggg ccccgagggg ctgaagctca tttctgacat catccgtgag    480

aagatgggta ttgacatcag tgtgctgatg ggagccaaca ttgccaatga ggtggctgca    540

gagaagttct gtgagaccac catcggcagc aaagtaatgg agaacggcct tctcttcaaa    600

gaacttctgc agactccaaa ttttcgaatt accgtggttg atgatgcaga cactgttgaa    660

ctatgtggtg cgcttaagaa catcgtagct gtgggagctg ggttctgcga cggcctccgc    720

tgtggagaca acaccaaagc ggccgtcatc cgcctgggac tcatggaaat gattgctttt    780

gccaggatct tctgcaaagg ccaagtgtct acagccacct tcctagagag ctgcggggtg    840

gccgacctga tcaccacctg ttacggaggg cggaaccgca gggtggccga ggccttcgcc    900

agaactggga agaccattga agagttggag aaggagatgc tgaatgggca aaagctccaa    960

ggaccgcaga cttctgctga agtgtaccgc atcctcaaac agaagggact actggacaag   1020

tttccattgt ttactgcagt gtatcagatc tgctacgaaa gcagaccagt tcaagagatg   1080

ttgtcttgtc ttcagagcca tccagagcat acataaagtg aatcatgcaa cgtgttgggg   1140

gaagttctgc ctttctgatc aatcttttgg gttcacgtgg aaaccaggac ttggcaacat   1200

gatgtttgac tgtaatctca tcacggatat gtatgaattt ttacaggttc gtttttgaat   1260

tgtgagaggc agttcattag caaagatgta ctgggcagta actaaacaca catgcaaaca   1320

tgtgaatggt ggtttattcc tcattctgtg gatgtttcta tgagccaaaa tttgatgtct   1380

ttttttcaaa attgcttatg aaatttccac acaatcgtag cttataagat tggaacgatc   1440

tcagccaaat attttaggtg taattcatat gtatttgagt ggaggatttt ttttctcatt   1500

tttctagtgt taaattttaa ccagcattaa catggtagag tggaggagtg agtgtgttca   1560

aagatcaaca tatttaactt ttaaacacta tctcaaagcc agcataatta actactttga   1620

ttgtgggctg acctttgttt ttttaacaat caggcatttt taattagata atccactcat   1680

gtatttcccc ctcactgcag ttgtctgcat ttttagcctc ttttctcttc gttagttgtc   1740

agaatatgcc ttcgtcaagg ctcagaggta acaagacaga aaattcatct gggattttcc   1800

tgctgtggct ggcacattct tctgattaac agacacttgt atgatgcttt aggctagtta   1860

gtgcattttt tagcaaacat ttatcttaaa catcacagat ccactggggg gtgcaagggg   1920

ctactgttag tcctcttgtt agatgcagtc actcctcctg gtcacctagt gagcagggac   1980

agagccagga gtcaagtgca gtgccaaggt gcatgaccct ctgagaagtc actgggctga   2040

tttgacctcc gactcattgg ttgtgcaaat gccatgtgca gcctttcctg aggccatagg   2100

agggcttcct gcagctgaga tctatgcagg ccatcctctc aacaagtgcc actccaaggg   2160

cggtcctcgg tgcagcagca tcagcttcac ttgtgggggg gtgggggaag gggcggtctc   2220

agaaatgcag gttcccaggt cccaccctgg acttctgaag gggtgtggca tctgtgtttc   2280

tgatgcttac tacaatatgt gaaccactac tttagaaaat ctgctttaac ttggtattcc   2340

tctaattgtg ttccctagga aatgactgtc ccaagagcca gtgattattc caggtgttcc   2400

ctggaaaggt caagtgagtc tgggaaacac tatgtctgta cacctcttga aggtgtcgaa   2460

tgtatgttta tacatcagtg gaacccattt ttctagccta gcaagtccca aacacattac   2520

actgaagaga ttttggtgag gaaacttgct ggagttttca gggaacactg ttctaggctt   2580

aggtgacctt aggatcactc aagtagacgc ttcactccct gcgagaaatt aggatgaata   2640

actacctgtg gcattgttgg ttctgaactt ttacagttca ggcctgctgt gaatctttga   2700

tgaagcttta aggtgacact gttgtacaag atgtcagctt tgctgaaacg cacattacct   2760

ggaataagtg ctttaattgt agaattagaa tgggatttac tgtactgttt taaatgagat   2820

tggcttcaga atccattaca gttaccttac atagcacttg atacgtgtta aatgaacata   2880

tgaatgtaat ttatatattc ctagaattta agttactttg tgagatttgg gcctgtccct   2940

caatgccagt ttaggatttc tttttttcta taccttgaaa tgattataaa atagattttc   3000

atgggaattt taaaaactct atccaaaaca tttttggagc attttaaagc cccatacaca   3060

gaagtatacg aaagcacaca aaacactcca agtttcagca gttttagcgc caccattaac   3120

ccactttgct tgtctcatga aaaatctttg ttaaagtttg tacacaggta acaaaaagtt   3180

actttaaaag atatataaag ggctgtaagc taattgtggt gtctagtaag tagcataatg   3240

agatgtgagg agttggaact ttgcgtgttt tgcgtatttt catctgcatt cagcttctta   3300

ctctgggttt gtactcgagt gttatttctt tacaaatgcc cttgtaatta ccactctgaa   3360

gtctgctgac tgtgtctctt gaacatactt aggatattct gcacattatg gaaaaaggta   3420

aattttagaa gtttctgctc tactaactgt agatatttat gactctgcga gttatctatt   3480

tttataacca cctgtggtcc attgttcatt ttaattcaca tttcttatga agtatggtaa   3540

cagggaggga gacacctaga ttagcagctc aatttgtact acttcagcca atctgtgaat   3600

gtaaaaacta cactgttgcc ttgctaggat ccaccctcct ataatatgga acaaatatct   3660

gaatgaaatc caccctagga gacggagtca aactaaactt gtggtttttc atttaacttt   3720

tgactacagc atggccccat ggcatccaca ccaagagggt gttgtgatga ggtgccggtg   3780

tgcaaaggga actttagttt ttccactggt tcttatctgc tagcctttta catacatgtg   3840

tactatattt gtttatagac tgtaggtgga tatataattt aaaagcttga tttaataaac   3900

atttaacccc ataaaaaaaa aaaaaaaaaa aaaaaaagaa aaaaaaaaaa aaaa         3954


<210>  204
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  204

Met Ala Ala Ala Pro Leu Lys Val Cys Ile Val Gly Ser Gly Asn Trp 
1               5                   10                  15


Gly Ser Ala Val Ala Lys Ile Ile Gly Asn Asn Val Lys Lys Leu Gln 
            20                  25                  30


Lys Phe Ala Ser Thr Val Lys Met Trp Val Phe Glu Glu Thr Val Asn 
        35                  40                  45


Gly Arg Lys Leu Thr Asp Ile Ile Asn Asn Asp His Glu Asn Val Lys 
    50                  55                  60


Tyr Leu Pro Gly His Lys Leu Pro Glu Asn Val Val Ala Met Ser Asn 
65                  70                  75                  80


Leu Ser Glu Ala Val Gln Asp Ala Asp Leu Leu Val Phe Val Ile Pro 
                85                  90                  95


His Gln Phe Ile His Arg Ile Cys Asp Glu Ile Thr Gly Arg Val Pro 
            100                 105                 110


Lys Lys Ala Leu Gly Ile Thr Leu Ile Lys Gly Ile Asp Glu Gly Pro 
        115                 120                 125


Glu Gly Leu Lys Leu Ile Ser Asp Ile Ile Arg Glu Lys Met Gly Ile 
    130                 135                 140


Asp Ile Ser Val Leu Met Gly Ala Asn Ile Ala Asn Glu Val Ala Ala 
145                 150                 155                 160


Glu Lys Phe Cys Glu Thr Thr Ile Gly Ser Lys Val Met Glu Asn Gly 
                165                 170                 175


Leu Leu Phe Lys Glu Leu Leu Gln Thr Pro Asn Phe Arg Ile Thr Val 
            180                 185                 190


Val Asp Asp Ala Asp Thr Val Glu Leu Cys Gly Ala Leu Lys Asn Ile 
        195                 200                 205


Val Ala Val Gly Ala Gly Phe Cys Asp Gly Leu Arg Cys Gly Asp Asn 
    210                 215                 220


Thr Lys Ala Ala Val Ile Arg Leu Gly Leu Met Glu Met Ile Ala Phe 
225                 230                 235                 240


Ala Arg Ile Phe Cys Lys Gly Gln Val Ser Thr Ala Thr Phe Leu Glu 
                245                 250                 255


Ser Cys Gly Val Ala Asp Leu Ile Thr Thr Cys Tyr Gly Gly Arg Asn 
            260                 265                 270


Arg Arg Val Ala Glu Ala Phe Ala Arg Thr Gly Lys Thr Ile Glu Glu 
        275                 280                 285


Leu Glu Lys Glu Met Leu Asn Gly Gln Lys Leu Gln Gly Pro Gln Thr 
    290                 295                 300


Ser Ala Glu Val Tyr Arg Ile Leu Lys Gln Lys Gly Leu Leu Asp Lys 
305                 310                 315                 320


Phe Pro Leu Phe Thr Ala Val Tyr Gln Ile Cys Tyr Glu Ser Arg Pro 
                325                 330                 335


Val Gln Glu Met Leu Ser Cys Leu Gln Ser His Pro Glu His Thr 
            340                 345                 350


<210>  205
<211>  1548
<212>  DNA
<213>  Homo sapiens

<400>  205
gccctaggag ataaagatat gacaaggttc ttgccttcaa ggagctgtca gtctgagaca     60

gaaagagaca ggaagtcaga gagacataac aatctatgat ggtcatctca cagggtgaaa    120

tggaggcaaa gaggaggggg ttcagcaatg gtttcgccat gaatgtgacc cttaaaatgt    180

ggctgggagc aacctggaca ttacagcagg aaataacaaa agtcattcag aactgggatg    240

accatatgtc ctagtttccc caggataata tgtttgcttc tgttgtcaca gtttgagtat    300

cagtagcacc cttttttcct ctcaaaatac atgtttgata tatgcatgct ttcaaagtat    360

ttccctaaaa aattgttgga attatgaagg aaaaaaatag taactttgca gtagagaaat    420

ctggcagatg cttaatccag taatgaagat taatatcttc acagatggta ccaatgaaca    480

tcatgtgcct cctgttaaga tttgctcaga actttccacg ctacccacag aggggtgcat    540

acagcattgt tctggattcc agtcgtaact taaacggaaa ctttcacaat gtccggagcc    600

cttgatgtcc tacaaatgaa ggaggaggat gtccttaagt tccttgcagc aggaacccac    660

ttaggtggca ctaatcttga cttccagatg gaacagtacg tctataaaag gaagtgatgg    720

catctacatc ctaaatctga agaggacctg ggagaagctt ctgctggcag ctcgtgccat    780

tgttgccatt gaaaaccctg ctgatgtcag tgtcatatcc tccaggaata ctggccagag    840

ggctgtgctg aagtttgctg ctgctggaac cactccaatt gctgaccgct tcacccctgg    900

aaccttcacc aatcagatcc aggcagcttt ccgggagcca tggcttcttg tgtttactga    960

ccccagagct gaccaccagc ctctcccgga gacatcttat gttaacctac ctaccattgc   1020

tctgtaacac agattctcct ctgtgctatg tggacattgc catcccatgc aacaacaagg   1080

gagctcactc agtgggtctg atgtggtgga tgctggctcg ggaagttctg cgcatgcgtg   1140

gcaccatttc ccgtgaacac ccataggagg tcatgcctga tctctgcttc tacagagatc   1200

ctgaagagat tgaaaaagaa gagcaggctg ctgctgaaaa ggctgtgacc aagaaggaac   1260

ttcagggcga atggactgct ccagctcctg agttcactgc tactcagcct gaggttgcag   1320

actggtctga aggtgtgcag gtgccctctg tgcctatcca gcagatccct actgaagact   1380

agagctctca gcatgccacg gaagactggt ctacagctcc cactgctcag gccactgaat   1440

gggtaggagc aaccactgaa tggtcttaag ctgttcttgc acaggctctt aagcaacatg   1500

gaaataaggc tgatggaaaa taaacatcag tttctaaaaa aaaaaaaa                1548


<210>  206
<211>  1185
<212>  DNA
<213>  Homo sapiens

<400>  206
ggcctccacc gccttccccg gctgcccggc agcctcccct cgctcgctct cctcttcctc     60

tagggcccca gcgcagctcg ggagcccgcg caccgaggcg ctaggggcac cgcgcactag    120

agggacaccc gccgcgcctg gacagccccc ggcgggcgcc cccctcgcac ctcctgcccc    180

gcgcgggccg cgctcccctc ccccgcgcct gtgtccccag ggcgcagggc cgcgcgtcca    240

gccccagacc cgccggggtc cctggggacg cgccagcccg gcagtggctc gacgatggag    300

gagccgcagc gcgcccgctc gcacacagtc accaccaccg ccagctcctt cgcagagaac    360

ttctccacca gcagcagcag cttcgcctac gaccgggagt tcctccgcac cctgcccggc    420

ttcctcatcg tggccgagat cgttctgggg ctgctggtat ggacgcttat tgctggaact    480

gagtacttcc gggtccccgc atttggctgg gtcatgtttg tagctgtatt ttactgggtc    540

ctcaccgtct tcttcctcat tatctacata acaatgacct acaccaggat tccccaggtg    600

ccctggacaa cagtgggcct gtgctttaac ggcagtgcct tcgtcttgta cctctctgcc    660

gctgttgtag atgcatcttc cgtctcccct gagagggaca gtcacaactt caacagctgg    720

gcggcctcat cgttctttgc cttcctggtc accatctgct acgctggaaa tacatatttc    780

agttttatag catggagatc caggaccata cagtgattta ccattttgat aattaaaagg    840

aaaaaaaaag gaagactctc actgtaaaaa cagctgtagg tataatgtat attcccagag    900

aattgtattt aactaattaa tgttttttat attcttaaat ttgctcacaa attgtggttt    960

gttacaatta aactggatac ttatttgcaa agtgttgtag cttataatga actcttaagt   1020

atcttattaa tgtattaatg tcttcataga tcatattttc ttagacaatg tttaaataga   1080

taaattgcta atattgagaa tgtgtcaagt ttgtaaacct aacttttaag atgccagatt   1140

cttttttgat taaatgttgc aaaatcccaa aaaaaaaaaa aaaaa                   1185


<210>  207
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  207

Met Glu Glu Pro Gln Arg Ala Arg Ser His Thr Val Thr Thr Thr Ala 
1               5                   10                  15


Ser Ser Phe Ala Glu Asn Phe Ser Thr Ser Ser Ser Ser Phe Ala Tyr 
            20                  25                  30


Asp Arg Glu Phe Leu Arg Thr Leu Pro Gly Phe Leu Ile Val Ala Glu 
        35                  40                  45


Ile Val Leu Gly Leu Leu Val Trp Thr Leu Ile Ala Gly Thr Glu Tyr 
    50                  55                  60


Phe Arg Val Pro Ala Phe Gly Trp Val Met Phe Val Ala Val Phe Tyr 
65                  70                  75                  80


Trp Val Leu Thr Val Phe Phe Leu Ile Ile Tyr Ile Thr Met Thr Tyr 
                85                  90                  95


Thr Arg Ile Pro Gln Val Pro Trp Thr Thr Val Gly Leu Cys Phe Asn 
            100                 105                 110


Gly Ser Ala Phe Val Leu Tyr Leu Ser Ala Ala Val Val Asp Ala Ser 
        115                 120                 125


Ser Val Ser Pro Glu Arg Asp Ser His Asn Phe Asn Ser Trp Ala Ala 
    130                 135                 140


Ser Ser Phe Phe Ala Phe Leu Val Thr Ile Cys Tyr Ala Gly Asn Thr 
145                 150                 155                 160


Tyr Phe Ser Phe Ile Ala Trp Arg Ser Arg Thr Ile Gln 
                165                 170


<210>  208
<211>  1606
<212>  DNA
<213>  Homo sapiens

<400>  208
atgtcttgct gtgggagaaa ttcagcttgt tgggtcctct cggtggcggc ggcagatcct     60

gggagcagga agcttggctt agtggctatt gagtttgtgt tgagtgtcag agacacctgg    120

tgcctttctc acctgatctc cacgtggatg gcctcctccc tgaaaataaa gcttcctaag    180

atcaggggaa gaggaaaggg cttctttctt ttcctaatta tctccctggt agtaacattg    240

agcgtgagct tcaccactcg ttccaccttc tcctccaact gccagtccgt gggctctgtc    300

caggggccca gctactggca tccagccagt cagcagtgca gcaagcatct atgcaggcgc    360

cggagggcag ggggtggctc tggttcccgg atcaccgtgt cctgctccac cagcttccag    420

ggtggcatgg ggtccgggga cctggccgca gggacggcca ggggtctggc agaaatggga    480

ggcatccaga gcgggaagga gaccacgcac agcctgaacg actgcctggc ctcctacctg    540

gacaaagtga agagcctgga gaccgtgaac tggaggctgg agagcaaaat cccctgaagg    600

gaccccaggt cagagactgg gccattactt caagaccatc aaagacctga gggctcaggt    660

cttctcaaat actgtggaca atgcccgcat tgttctgcag attgacaatg cctgtcttgc    720

tgctgatgac tttagagtca agtatgagac agaactggcc atgtgccagt ctttggagaa    780

tgacattcat gggctcttca aggtcattga tgacaccaat gtcactcggc tgcagctgga    840

gacagagatc gaggctctca agaaggaact gctcttcatg aagaagaacc atgaagagga    900

agtaaaaggc ctacaagccc agattgccag ctctgggttg accgtggagg tagatgcccc    960

caaatctcag gaccttgcca agatcatggc agacatccag gcccaatatg acgagctggc   1020

tcggaagaac tgagaggagc tggacaagta ctggtctcag cagattgagg agagcaccac   1080

agtggtcacc acacagtccg ccgaggttgg agctgctgag atgccactca cggagctgag   1140

acatgcagtc cagtccttgg agattgacct ggactccatg agaaatgtga aggccagcct   1200

ggagaacagc ctgagggagg tggaggcccg ctacaccctg cagatagagc agctcaacgg   1260

gatcctgctg cacctggagt cagagctggc actgacccag gcagagggac agcaccaggc   1320

ccaggagtac aaggccctgc tgaacatcaa ggtcaagctg gaggctgaga tcgccagcta   1380

ccatcgcctg ttggaagatg gcgaggactt caatcttggt gatgccctgg acagcagcaa   1440

ctccatgcaa accatccaaa agaccaccac ctgccggaga gtggatggca aagtggtgtc   1500

tgagaccaac gacaccaaag ttctgagaca ttaagccagc agaagcaggg taccctttgg   1560

ggatcaggag gccaataaaa agttcagagg tcattggaaa aaaaaa                  1606


<210>  209
<211>  3291
<212>  DNA
<213>  Homo sapiens

<400>  209
acaatccaag ttaataatac atatcttgtg tattgtcata aaaatgtgtt aaatatttac     60

cgtgtgccag aatctgtgtc tagcccttag aatatagtgg taaatagcac ctttctatgt    120

ttatttaaac aaatgatcaa ttataggaat taagacatgt aaagaaaaat atgcttaaaa    180

atatattaaa ttatagtagg aaaaactcaa gttttcaaat ttgaggtgaa attcaagagg    240

catttattcc ttgtaggcat ttggtccttt attcacccca tagagagggt taaatctaaa    300

atttgacagg aaaataccat ttgtttgttt gtttttgcta agatttatga gtagcactgt    360

ttctaggaag gtgcccgtac ttttccttag atgagcactc taccatttaa agggttttca    420

cgttcattgt ctcagttgat aataaaccag tcccaggtta tggggaatcc ctcctttctt    480

tcatttccat ttctacttga accatgattt gaggaaacag ttcttaaata acacatgaat    540

gagtcaacca cacccttgtg gagttcagtg tgaaacaaat gccatccgat tgcttgtcca    600

tcctctgtac acacccatga gattcatggt gccagcctag taatatgtcc ctttcatggg    660

aaagtagaat attcattgtc ttagagttca actgaagatg acaatctact gtagctggtt    720

gaagccgcaa gggatttatt atgcatcatt agttggcttc caaaattttt ggtagggttg    780

gaggagcagg ctctaggctg agcttccagg agcacctact ggaatcatac catggaactg    840

gcctgccatc agaaggaaga cgaggaagca ggatctactc tcatgtctgc tgggtcctgg    900

atgtccattg tccccattgc gagtcatgat atcacatggc tgccccctga cttgcctctc    960

aacaccacga agcgaggaat gggacgctgg gatttcagtt ttctgtggac tgccacagaa   1020

aaagaagtac cttcttggct atgtctgcca gcaggaacaa agaggcatcc aaagcatgtc   1080

ctttgggcca tggcattgtc tttttccttc taagtctagg atgggtgtgt ctgctgaagc   1140

tacatcattg tgtggaacct gagctgtggt ccagctttcc agcctctagt gagcagtaag   1200

gcacactgca aggggaatgt ggcagaggtg agtggatcca catggagtat ttactacatc   1260

cacttcattg gattctacct ggatcactgt gttggaggtg gaaggccatc tgtgatttgt   1320

ggtgcttcta aaacattcta aggacgtgcc ctatttcagt taagacacac atttgatttc   1380

tagctatgca acctttacaa ctgacctgat acttcctgaa cttccatctg taataatgag   1440

aaagataatg acgatgtcac atgttagtag aagataaagt gagcaaaaat acaccgaagc   1500

tctgtctcag aggaaaatat tagcttattt cttgggttac tgtaggctta tttcttccct   1560

tttttaatca gccggtccaa atattgtaca ttaattcccc ctggactggg ctgtatttgg   1620

aatgagtggt catatcagct tctagtgagt tttcacacac tcagcaatga gcgggaacat   1680

agaatttagc ctctctggta catactaggg ttaggattag gatcatactt gtaactaaag   1740

aaagcttaaa agctatatta aaaaccacag agcagggcag ttccaaaata gccgaatagg   1800

aacagctcca atctacagct cccagtgtga acgatgcaga agacagatga tttctgcatt   1860

tccaactgag attggaagac agtagcggtt ctctcagcac gcagcttgag atctgagaac   1920

ggacagactg cctcttcaag tgggtccctg acccctgagt agcctaactg ggaggcaccc   1980

cccagtaggg gcagactgac acctcacaca gctgggtacc cctctgagac aaaacttcaa   2040

gaggaacaat caggcagcaa cgtttgcatt tcaccaatat tcgctgttct gcagcctccg   2100

ctgctgatac ccaggcaaac ggtctggagt ggacctccgg caaactccaa cagacctgca   2160

gctgagggtc ctgactgtta gaaggaaaac taacaaacag aaaggacatc cacaccaaaa   2220

ccccatctgt acgtcaccat catcaaagac caaaggtaga taaaaccaca aagatgggga   2280

aaaaaacgag cagaaaaact gaaaattcta aaaatcagag cgcctctcct cctccaaagg   2340

aacgcagctc ctcaccagca acagaacaaa gctgggccga gaatggcttt gacgagttga   2400

gagaagaagg cttcagacaa tcaaacttct ccgagctaaa ggaggaagtt cgaacccatg   2460

gtaaggaagt taaaaacctt gaaaaaagat tagacgaatg gctaactaga ataaccaatg   2520

cagagaagtc cttaaaggac ctcatggagc tgaaaaccac ggcacgagaa ctacgtgacg   2580

aatgcacaag cctcagtagc caattcgatc aaccggaaga aagggtatca gtgatggaag   2640

atcaaatgaa tgaaataaag cgagaagaga agtttagaga aaaaagaata aaaagaaacg   2700

aacaaagcct ccaagaaata tgggactatg tgaaaagacc aaatctatgt ctgattggtg   2760

tacctgaaag tgacaaggag aatgcaacca agttggaaaa cactctgcag gatattatcc   2820

aggagaactt ccccaatcta gcaaggcagg ccaacattca aattcaggaa atacagagaa   2880

ctccacaaag atactccttg agaagagcaa ctccaagaca cataattgtc agattcacca   2940

aagttgaaat gaaggaaaaa atgttaaggg cagccagaga gaaaggtcgg gttacccacg   3000

aggggaagcc catcagacta acagctgctc tctcagcaga aactctacaa gccagaagag   3060

agtgggggtc aatattcaaa attcttaaag aaaagaattt ttaacccaga atttcatgtc   3120

cagccaacta agtaagcttc gtaagtgaag gagaaataaa atcctttaca gacaagcaaa   3180

tgctgagcga ttttgtcacc actaggcctg ccctacaaga gctcctgaag gaagcactaa   3240

acgtggaaag gaaacccgta ccagccactg caaaaacatg ccaaattgta a            3291


<210>  210
<211>  5787
<212>  DNA
<213>  Homo sapiens

<400>  210
atgttacttc ctgtatggag gcatggccag tttccagcgc cgcgctcttc gttccttccc     60

agcctgcgcc ggagccacaa ctttcaggag catggactga aggcgccctc gccccagcgc    120

ccctctgaga tcctttgtgt tttcctccgt ttcctccggc cgtttctatt ttggggggct    180

ctccgctccc cctgcctctc ccctcccctt cccctctcgc aaacatgcct ccttccttcc    240

cggggccctg gaaggagctg cctgcctgaa gcccggagac gccgcgccgc gctcagcccc    300

gccgccgccc gccggctctc gggctgtgct gcgctgccga ctcaagttgg ggatcctcgg    360

ctgctcgccg ccgccgcccg cggtccctgt ctgccccagg cccggggcat cgccgccggc    420

cgccgactcc gcgccctgcc cgatcggctc tctccttttt aaacggaaag cagcctttct    480

ccgccgagag gatcgtcccc agcgtggctc tgcgttcccg gtcacttttt gagattttcc    540

ggggggcgct cggcggcttc ccggattcca aggggactcg ggccgccgag cgcggggggc    600

ccgtggagcg ggcgagccgg ggaagcgccc cggcttagcg gaggctcgca cggaggcaag    660

aacttattca acaagtttac ctccctgctt tcctcttttc gatgtgcgtt ttcggacatg    720

cggaggttac tggaaccgtg ttggtggatt ttgttcctga aaatcaccag ttccgtgctc    780

cattatgtcg tgtgcttccc cgcgttgaca gaaggctacg ttggggccct gcacgagaat    840

agacacggca gcgcagtgca gatccgcagg cgcaaggctt caggcgaccc gtactgggcc    900

tactctggtg cctatggtcc tgagcactgg gtcacgtcta gtgtcagctg tgggagccgt    960

caccagtctc ctattgacat tttagaccag tatgcgcgtg ttggggaaga ataccaggaa   1020

ctgcaactcg atggcttcga caatgagtct tctaacaaaa cctggatgaa aaacacaggg   1080

aaaacagtcg ccatccttct gaaagacgac tattttgtca gtggagctgg tctacctggc   1140

agattcaaag ctgagaaggt ggaatttcac tggggccaca gcaatggctc agcgggctct   1200

gaacacagca tcaatggcag gaggtttcct gttgagatgc agattttctt ttacaatcca   1260

gatgactttg acagctttca aaccgcaatt tctgagaaca gaataatcgg agccatggcc   1320

atattttttc aagtcagtcc gagggacaat tctgcactgg atcctattat ccacgggttg   1380

aagggtgtcg tacatcatga gaaggagacc tttctggatc ctttcgtcct ccgggacctc   1440

ctgcctgcat ccctgggcag ctattatcgg tacacaggtt ccttgaccac accaccgtgt   1500

agcgaaatag tggagtggat agtcttccgg agacccgtcc ccatctctta ccatcagctt   1560

gaggcttttt attccatctt caccacggag cagcaagacc atgtcaagtc ggtggagtat   1620

ctgagaaata actttcgacc acagcagcgt ctgcatgaca gggtggtgtc caagtccgcc   1680

gtccgtgact cctggaacca cgacatgaca gacttcttag aaaacccact ggggacagaa   1740

gcctctaaag tttgcagctc tccacccatc cacatgaagg tgcagcctct gaaccagacg   1800

gcactgcagg tgtcctggag ccagccggag actatctacc acccacccat catgaactac   1860

atgatctcct acagctggac caagaatgag gacgagaagg agaagacgtt tacaaaggac   1920

agcgacaaag acttgaaagc caccattagc catgtctcac ccgatagcct ttacctgttc   1980

cgagtccagg ccgtgtgtcg gaacgacatg cgcagcgact ttagccagac gatgctgttt   2040

caagctaata ccactcgaat attccaaggg accagaatag tgaaaacagg agtgcccaca   2100

gcgtctcctg cctcttcagc cgacatggcc cccatcagct cggggtcttc tacctggacg   2160

tcctctggca tcccattctc atttgtttcc atggcaactg ggatgggccc ctcctccagt   2220

ggcagccagg ccacagtggc ctcggtggtc accagcacgc tgctcgccgg cctggggttc   2280

ggcggtggtg gcatctcctc tttccccagc actgtgtggc ccacgcgcct cccgacggcc   2340

gcctcagcca gcaagcaggc ggctaggcca gtcctagcca ccacagaggc cttggcttct   2400

ccagggcccg atggtgattc gtcaccaacc aaggacggcg agggcaccga ggaaggagag   2460

aaggatgaga aaagcgagag tgaggatggg gagcgggagc acgaggagga tggagagaag   2520

gactccgaaa agaaggagaa gagtggggtg acccacgctg ccgaggagcg gaatcagacg   2580

gagcccagcc ccacaccctc gtctcctaac aggactgccg agggagggca tcagactata   2640

cctgggcatg agcaggatca cactgccgtc cccacagacc agacgggcgg aaggagggat   2700

gccggcccag gcctggaccc cgacatggtc acctccaccc aagtgccccc caccgccaca   2760

gaggagcagt atgcagggag tgatcccaag aggcccgaaa tgccatctaa aaagcctatg   2820

tcccgcgggg accgattttc tgaagacagc agatttatca ctgttaatcc agcggaaaaa   2880

aacacctctg gaatgataag ccgccctgct ccagggagga tggagtggat catccctctg   2940

attgtggtat cagccttgac cttcgtgtgc ctcatccttc tcattgctgt gctcgtttac   3000

tggagagggt gtaacaaaat aaagtccaag ggctttccca gacgtttccg tgaagtgcct   3060

tcttctgggg agagaggaga gaaggggagc agaaaatgtt ttcagactgc tcatttctat   3120

gtggaagaca gcagttcacc tcgagtggtc cctaatgaaa gtattcctat tattcctatt   3180

ccggatgaca tggaagccat tcctgtcaaa cagtttgtca aacacatcgg tgagctctat   3240

tctaataacc agcatgggtt ctctgaggat tttgaggaag tccagcgctg tactgctgat   3300

atgaacatca ctgcagagca ttccaatcat ccagaaaaca agcacaaaaa cagatacatc   3360

aacattttag catatgatca cagtagggtg aagttaagac ctttaccagg aaaagactct   3420

aagcacagcg actacattaa tgcaaactat gttgatggtt acaacaaagc aaaagcctac   3480

attgccaccc aaggaccttt gaagtctaca tttgaagatt tctggaggat gatttgggaa   3540

caaaacactg gaatcattgt gatgattacg aaccttgtgg aaaaaggaag acgaaaatgt   3600

gatcagtatt ggccaacaga gaacagtgag gaatatggaa acattattgt cacgctgaag   3660

agcacaaaaa tacatgcctg ctacactgtt cgtcgttttt caatcagaaa tacaaaagtg   3720

aaaaagggtc agaagggaaa tcccaagggt cgtcagaatg aaagggtagt gatccagtat   3780

cactatacac agtggcctga catgggagtt cccgagtatg cccttccagt actgactttc   3840

gtgaggagat cctcagcagc tcggatgcca gaaacgggcc ctgtgttggt gcactgcagt   3900

gctggtgtgg gcagaacagg cacctatatt gtaatagaca gcatgctgca acagataaaa   3960

gacaaaagca cagttaacgt cctgggattc ctgaagcata tcaggacaca gcgtaactac   4020

ctcgtccaga ctgaggagca gtacattttc atccatgatg ccttgttgga agccattctt   4080

ggaaaggaga ctgaagtatc ttcaaatcag ctgcacagct atgttaacag catccttata   4140

ccaggagtag gaggaaagac acgactggaa aagcaattca agctggtcac acagtgtaat   4200

gcaaaatatg tggaatgttt cagtgctcag aaagagtgta acaaagaaaa gaacagaaac   4260

tcttcagttg tgccatctga gcgtgctcga gtgggtcttg caccattgcc tggaatgaaa   4320

ggaacagatt acattaatgc ttcttatatc atgggctatt ataggagcaa tgaatttatt   4380

ataactcagc atcctctgcc acatactacg aaagatttct ggcgaatgat ttgggatcat   4440

aacgcacaga tcattgtcat gctgccagac aaccagagct tggcagaaga tgagtttgtg   4500

tactggccaa gtcgagaaga atccatgaac tgtgaggcct ttaccgtcac ccttatcagc   4560

aaagacagac tgtgcctctc taatgaagaa caaattatca tccatgactt tatccttgaa   4620

gctacacagg atgactatgt cttagaagtt cggcactttc agtgtcccaa atggcctaac   4680

ccagatgccc ccataagtag tacctttgaa cttatcaacg tcatcaagga agaggcctta   4740

acaagggatg gtcccaccat tgttcatgat gagtatggag cagtttcagc aggaatgtta   4800

tgtgccctta ccaccctgtc ccagcaactg gagaatgaaa atgctgtgga tgttttccag   4860

gttgcaaaaa tgatcaatct tatgaggcct ggagtattca cagacattga acaataccag   4920

ttcatctata aagcaaggct tagcttggtc agcactaaag aaaatggaaa tggtcccatg   4980

acagtagaca aaaatggtgc tgttcttatt gcagatgaat cagaccctgc tgagagcatg   5040

gagtccctag tgtgactgga atcctgaaag ggcacttaat ttgtaaactt ctgaagactg   5100

agaacttttt tgaggccttt tttgccagac tctaggttat acaataaccc agttactttt   5160

ttacactgat aaaagttttg atatttattt tttgccattt tatgtcttaa tggtatccta   5220

ctgagcattt gcacctctgt tcatttcaca cagtgaaacg caattttacc tagtttgcac   5280

tatatgatca gtgttactgc ctataatctt atacaacagc aaaccctgat gtgacattcc   5340

atgacgacat acatgctact tttttttagt tcaatacagt gaaggtcttt gttatgacag   5400

tgaatattgc ttttattatt attattgctg aagtggttgc attctactag caggcaatgc   5460

tgtacttttc ttcagtcctc ctctcctttt tattttaggc actgttcaat actgtatgcc   5520

ttctgtattt taatggagtg gatagcattg ttttctttta cagactagca ggctactggg   5580

acctaaaaag gtctgttaat gtcatggcct tgaaacagtt ccatttatgc tggttaagag   5640

atcccttaag aagttagaag gcttaagaac tgcttcatgt gaacatccct tattagttac   5700

aaagttatat tcacagtttt ttaaaaatgt gtcaaaataa aggataactc tgtattacag   5760

ctttcccagt aaaaaaaaaa aaaaaaa                                       5787


<210>  211
<211>  1445
<212>  PRT
<213>  Homo sapiens

<400>  211

Met Arg Arg Leu Leu Glu Pro Cys Trp Trp Ile Leu Phe Leu Lys Ile 
1               5                   10                  15


Thr Ser Ser Val Leu His Tyr Val Val Cys Phe Pro Ala Leu Thr Glu 
            20                  25                  30


Gly Tyr Val Gly Ala Leu His Glu Asn Arg His Gly Ser Ala Val Gln 
        35                  40                  45


Ile Arg Arg Arg Lys Ala Ser Gly Asp Pro Tyr Trp Ala Tyr Ser Gly 
    50                  55                  60


Ala Tyr Gly Pro Glu His Trp Val Thr Ser Ser Val Ser Cys Gly Ser 
65                  70                  75                  80


Arg His Gln Ser Pro Ile Asp Ile Leu Asp Gln Tyr Ala Arg Val Gly 
                85                  90                  95


Glu Glu Tyr Gln Glu Leu Gln Leu Asp Gly Phe Asp Asn Glu Ser Ser 
            100                 105                 110


Asn Lys Thr Trp Met Lys Asn Thr Gly Lys Thr Val Ala Ile Leu Leu 
        115                 120                 125


Lys Asp Asp Tyr Phe Val Ser Gly Ala Gly Leu Pro Gly Arg Phe Lys 
    130                 135                 140


Ala Glu Lys Val Glu Phe His Trp Gly His Ser Asn Gly Ser Ala Gly 
145                 150                 155                 160


Ser Glu His Ser Ile Asn Gly Arg Arg Phe Pro Val Glu Met Gln Ile 
                165                 170                 175


Phe Phe Tyr Asn Pro Asp Asp Phe Asp Ser Phe Gln Thr Ala Ile Ser 
            180                 185                 190


Glu Asn Arg Ile Ile Gly Ala Met Ala Ile Phe Phe Gln Val Ser Pro 
        195                 200                 205


Arg Asp Asn Ser Ala Leu Asp Pro Ile Ile His Gly Leu Lys Gly Val 
    210                 215                 220


Val His His Glu Lys Glu Thr Phe Leu Asp Pro Phe Val Leu Arg Asp 
225                 230                 235                 240


Leu Leu Pro Ala Ser Leu Gly Ser Tyr Tyr Arg Tyr Thr Gly Ser Leu 
                245                 250                 255


Thr Thr Pro Pro Cys Ser Glu Ile Val Glu Trp Ile Val Phe Arg Arg 
            260                 265                 270


Pro Val Pro Ile Ser Tyr His Gln Leu Glu Ala Phe Tyr Ser Ile Phe 
        275                 280                 285


Thr Thr Glu Gln Gln Asp His Val Lys Ser Val Glu Tyr Leu Arg Asn 
    290                 295                 300


Asn Phe Arg Pro Gln Gln Arg Leu His Asp Arg Val Val Ser Lys Ser 
305                 310                 315                 320


Ala Val Arg Asp Ser Trp Asn His Asp Met Thr Asp Phe Leu Glu Asn 
                325                 330                 335


Pro Leu Gly Thr Glu Ala Ser Lys Val Cys Ser Ser Pro Pro Ile His 
            340                 345                 350


Met Lys Val Gln Pro Leu Asn Gln Thr Ala Leu Gln Val Ser Trp Ser 
        355                 360                 365


Gln Pro Glu Thr Ile Tyr His Pro Pro Ile Met Asn Tyr Met Ile Ser 
    370                 375                 380


Tyr Ser Trp Thr Lys Asn Glu Asp Glu Lys Glu Lys Thr Phe Thr Lys 
385                 390                 395                 400


Asp Ser Asp Lys Asp Leu Lys Ala Thr Ile Ser His Val Ser Pro Asp 
                405                 410                 415


Ser Leu Tyr Leu Phe Arg Val Gln Ala Val Cys Arg Asn Asp Met Arg 
            420                 425                 430


Ser Asp Phe Ser Gln Thr Met Leu Phe Gln Ala Asn Thr Thr Arg Ile 
        435                 440                 445


Phe Gln Gly Thr Arg Ile Val Lys Thr Gly Val Pro Thr Ala Ser Pro 
    450                 455                 460


Ala Ser Ser Ala Asp Met Ala Pro Ile Ser Ser Gly Ser Ser Thr Trp 
465                 470                 475                 480


Thr Ser Ser Gly Ile Pro Phe Ser Phe Val Ser Met Ala Thr Gly Met 
                485                 490                 495


Gly Pro Ser Ser Ser Gly Ser Gln Ala Thr Val Ala Ser Val Val Thr 
            500                 505                 510


Ser Thr Leu Leu Ala Gly Leu Gly Phe Gly Gly Gly Gly Ile Ser Ser 
        515                 520                 525


Phe Pro Ser Thr Val Trp Pro Thr Arg Leu Pro Thr Ala Ala Ser Ala 
    530                 535                 540


Ser Lys Gln Ala Ala Arg Pro Val Leu Ala Thr Thr Glu Ala Leu Ala 
545                 550                 555                 560


Ser Pro Gly Pro Asp Gly Asp Ser Ser Pro Thr Lys Asp Gly Glu Gly 
                565                 570                 575


Thr Glu Glu Gly Glu Lys Asp Glu Lys Ser Glu Ser Glu Asp Gly Glu 
            580                 585                 590


Arg Glu His Glu Glu Asp Gly Glu Lys Asp Ser Glu Lys Lys Glu Lys 
        595                 600                 605


Ser Gly Val Thr His Ala Ala Glu Glu Arg Asn Gln Thr Glu Pro Ser 
    610                 615                 620


Pro Thr Pro Ser Ser Pro Asn Arg Thr Ala Glu Gly Gly His Gln Thr 
625                 630                 635                 640


Ile Pro Gly His Glu Gln Asp His Thr Ala Val Pro Thr Asp Gln Thr 
                645                 650                 655


Gly Gly Arg Arg Asp Ala Gly Pro Gly Leu Asp Pro Asp Met Val Thr 
            660                 665                 670


Ser Thr Gln Val Pro Pro Thr Ala Thr Glu Glu Gln Tyr Ala Gly Ser 
        675                 680                 685


Asp Pro Lys Arg Pro Glu Met Pro Ser Lys Lys Pro Met Ser Arg Gly 
    690                 695                 700


Asp Arg Phe Ser Glu Asp Ser Arg Phe Ile Thr Val Asn Pro Ala Glu 
705                 710                 715                 720


Lys Asn Thr Ser Gly Met Ile Ser Arg Pro Ala Pro Gly Arg Met Glu 
                725                 730                 735


Trp Ile Ile Pro Leu Ile Val Val Ser Ala Leu Thr Phe Val Cys Leu 
            740                 745                 750


Ile Leu Leu Ile Ala Val Leu Val Tyr Trp Arg Gly Cys Asn Lys Ile 
        755                 760                 765


Lys Ser Lys Gly Phe Pro Arg Arg Phe Arg Glu Val Pro Ser Ser Gly 
    770                 775                 780


Glu Arg Gly Glu Lys Gly Ser Arg Lys Cys Phe Gln Thr Ala His Phe 
785                 790                 795                 800


Tyr Val Glu Asp Ser Ser Ser Pro Arg Val Val Pro Asn Glu Ser Ile 
                805                 810                 815


Pro Ile Ile Pro Ile Pro Asp Asp Met Glu Ala Ile Pro Val Lys Gln 
            820                 825                 830


Phe Val Lys His Ile Gly Glu Leu Tyr Ser Asn Asn Gln His Gly Phe 
        835                 840                 845


Ser Glu Asp Phe Glu Glu Val Gln Arg Cys Thr Ala Asp Met Asn Ile 
    850                 855                 860


Thr Ala Glu His Ser Asn His Pro Glu Asn Lys His Lys Asn Arg Tyr 
865                 870                 875                 880


Ile Asn Ile Leu Ala Tyr Asp His Ser Arg Val Lys Leu Arg Pro Leu 
                885                 890                 895


Pro Gly Lys Asp Ser Lys His Ser Asp Tyr Ile Asn Ala Asn Tyr Val 
            900                 905                 910


Asp Gly Tyr Asn Lys Ala Lys Ala Tyr Ile Ala Thr Gln Gly Pro Leu 
        915                 920                 925


Lys Ser Thr Phe Glu Asp Phe Trp Arg Met Ile Trp Glu Gln Asn Thr 
    930                 935                 940


Gly Ile Ile Val Met Ile Thr Asn Leu Val Glu Lys Gly Arg Arg Lys 
945                 950                 955                 960


Cys Asp Gln Tyr Trp Pro Thr Glu Asn Ser Glu Glu Tyr Gly Asn Ile 
                965                 970                 975


Ile Val Thr Leu Lys Ser Thr Lys Ile His Ala Cys Tyr Thr Val Arg 
            980                 985                 990


Arg Phe Ser Ile Arg Asn Thr Lys Val Lys Lys Gly Gln Lys Gly Asn 
        995                 1000                1005


Pro Lys Gly Arg Gln Asn Glu Arg Val Val Ile Gln Tyr His Tyr Thr 
    1010                1015                1020


Gln Trp Pro Asp Met Gly Val Pro Glu Tyr Ala Leu Pro Val Leu Thr 
1025                1030                1035                1040


Phe Val Arg Arg Ser Ser Ala Ala Arg Met Pro Glu Thr Gly Pro Val 
                1045                1050                1055


Leu Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Val 
            1060                1065                1070


Ile Asp Ser Met Leu Gln Gln Ile Lys Asp Lys Ser Thr Val Asn Val 
        1075                1080                1085


Leu Gly Phe Leu Lys His Ile Arg Thr Gln Arg Asn Tyr Leu Val Gln 
    1090                1095                1100


Thr Glu Glu Gln Tyr Ile Phe Ile His Asp Ala Leu Leu Glu Ala Ile 
1105                1110                1115                1120


Leu Gly Lys Glu Thr Glu Val Ser Ser Asn Gln Leu His Ser Tyr Val 
                1125                1130                1135


Asn Ser Ile Leu Ile Pro Gly Val Gly Gly Lys Thr Arg Leu Glu Lys 
            1140                1145                1150


Gln Phe Lys Leu Val Thr Gln Cys Asn Ala Lys Tyr Val Glu Cys Phe 
        1155                1160                1165


Ser Ala Gln Lys Glu Cys Asn Lys Glu Lys Asn Arg Asn Ser Ser Val 
    1170                1175                1180


Val Pro Ser Glu Arg Ala Arg Val Gly Leu Ala Pro Leu Pro Gly Met 
1185                1190                1195                1200


Lys Gly Thr Asp Tyr Ile Asn Ala Ser Tyr Ile Met Gly Tyr Tyr Arg 
                1205                1210                1215


Ser Asn Glu Phe Ile Ile Thr Gln His Pro Leu Pro His Thr Thr Lys 
            1220                1225                1230


Asp Phe Trp Arg Met Ile Trp Asp His Asn Ala Gln Ile Ile Val Met 
        1235                1240                1245


Leu Pro Asp Asn Gln Ser Leu Ala Glu Asp Glu Phe Val Tyr Trp Pro 
    1250                1255                1260


Ser Arg Glu Glu Ser Met Asn Cys Glu Ala Phe Thr Val Thr Leu Ile 
1265                1270                1275                1280


Ser Lys Asp Arg Leu Cys Leu Ser Asn Glu Glu Gln Ile Ile Ile His 
                1285                1290                1295


Asp Phe Ile Leu Glu Ala Thr Gln Asp Asp Tyr Val Leu Glu Val Arg 
            1300                1305                1310


His Phe Gln Cys Pro Lys Trp Pro Asn Pro Asp Ala Pro Ile Ser Ser 
        1315                1320                1325


Thr Phe Glu Leu Ile Asn Val Ile Lys Glu Glu Ala Leu Thr Arg Asp 
    1330                1335                1340


Gly Pro Thr Ile Val His Asp Glu Tyr Gly Ala Val Ser Ala Gly Met 
1345                1350                1355                1360


Leu Cys Ala Leu Thr Thr Leu Ser Gln Gln Leu Glu Asn Glu Asn Ala 
                1365                1370                1375


Val Asp Val Phe Gln Val Ala Lys Met Ile Asn Leu Met Arg Pro Gly 
            1380                1385                1390


Val Phe Thr Asp Ile Glu Gln Tyr Gln Phe Ile Tyr Lys Ala Arg Leu 
        1395                1400                1405


Ser Leu Val Ser Thr Lys Glu Asn Gly Asn Gly Pro Met Thr Val Asp 
    1410                1415                1420


Lys Asn Gly Ala Val Leu Ile Ala Asp Glu Ser Asp Pro Ala Glu Ser 
1425                1430                1435                1440


Met Glu Ser Leu Val 
                1445


<210>  212
<211>  2369
<212>  DNA
<213>  Homo sapiens

<400>  212
ctgccccgtg ccgagtttcc tgtttaagat ggcgtccccc gtagcagcgc aggccgggaa     60

gcttctgcga gccctagcgc tgcggccccg cttcctggcg gccgggtccc aggcagttca    120

attaacctcc agaagatggc tgaacctgca ggaataccag agcaagaaac tgatgtctga    180

caacggagtg agagttcaaa gattctttgt agcagacact gcaaatgaag ctctcgaggc    240

tgctaagaga ctaaatgcaa aagaaattgt tttaaaagcc cagatcttag ctggaggaag    300

aggaaaaggt gtcttcaata gtggtttgaa aggaggtgtt catttaacaa aagaccctaa    360

tgttgtggga cagctggcta aacagatgat tgggtacaat ctagcgacaa aacaaactcc    420

aaaagaaggt gtgaaagtta acaaggtgat ggttgctgaa gccttggata tttccagaga    480

aacctacctg gcaattctga tggaccggtc ctgcaatggc cccgtgctgg tgggcagccc    540

ccaggggggc gtcgacattg aagaggtggc tgcttcaaac ccggagctca tttttaagga    600

gcaaattgac atttttgaag gaataaagga cagccaagct cagcggatgg ccgaaaatct    660

aggcttcgtt gggcctttga aaagccaggc tgcagatcaa attacgaagc tgtataatct    720

cttcctgaaa attgatgcta ctcaggtgga agtgaatccc tttggtgaaa ctccagaagg    780

acaagttgtc tgttttgatg ccaagataaa ctttgatgac aacgcagaat tccgacaaaa    840

agacatattt gctatggacg acaaatcaga gaatgagccc attgaaaatg aagctgccaa    900

atatgatcta aaatacatag gactagatgg gaacattgcc tgctttgtga atggtgctgg    960

gctcgccatg gctacttgtg atatcatttt ccttaatggt gggaagccag ccaacttctt   1020

ggatcttgga ggtggtgtaa aggaagctca agtatatcaa gcattcaaat tgctcacagc   1080

tgatcctaag gttgaagcca tccttgtcaa tatatttggt ggtatcgtca actgtgccat   1140

cattgccaat gggatcacca aagcctgccg ggagctagaa ctcaaggtgc ccctggtggt   1200

ccggcttgaa ggaaccaacg tccaagaggc ccagaagata ctcaacaaca gcggactccc   1260

cattacttca gccattgacc tggaggatgc agccaagaag gctgtggcca gtgtggccaa   1320

gaagtgatgt ctttgtcctg atccaatgga gaaagaaagc catttttccg taaaaaggga   1380

tggttcatca ttgtgaaaga aatggttatc tcattgggga agaaaagggg agggggaagg   1440

caagaatcac tgaaaaatct taaatctgtg ttttctggaa taagatatct agacagccta   1500

aatctgattt tggtctttat aaaaataata tcttgtgttc tcatactttt ctgtcactgt   1560

aagcctgccc agtaggcagt gttttgcaga ctttggggag tggtctatgt ggccaaatat   1620

tgtgtgtata gacagaattt gaaatcaagt cctgcttcat ttacaagaat tttggtgggc   1680

atctaatcct acataatgaa aaagaaaaac agaccattta aaaactcaga caagattata   1740

tttaatatat taattactaa aaaggcataa gattacactg aacatattag ctactaaaaa   1800

ggcactgcta agacattcaa gcaaatagct attacacact actgcagatt ttacaggttt   1860

ctaattctaa catatgtttg aaaaatccgt gagtattcca aaatatattt aataatggaa   1920

tatctgcatt aatataccat ccatgtgttt ttaccatttg ccttaatatt gaatatactg   1980

tttacctcac actaaaaaga aaaccagaag ccttatttgt gattttggga gtggaagctt   2040

ccatttttgt gtcaaaaatg aatcctgatt cttatggaaa tctctgttat taagatattt   2100

caagatgaga caacactgaa gatcaaattg tgtttagtat cactatcttc tctcctcgtt   2160

tctctcttac tcctcatcct cccagaatct accagtttat ggtagaaaga tgggaacctt   2220

atttgaatgt gttttttttt tccatgatgt ccaattttgt tgtgggaaag gatttggata   2280

aaatttttgt ttaaattttg gtagattttt atctatacaa atttaaataa aattatgttt   2340

tgtaagctgt aaaaaaaaaa aaaaaaaaa                                     2369


<210>  213
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  213

Met Ala Ser Pro Val Ala Ala Gln Ala Gly Lys Leu Leu Arg Ala Leu 
1               5                   10                  15


Ala Leu Arg Pro Arg Phe Leu Ala Ala Gly Ser Gln Ala Val Gln Leu 
            20                  25                  30


Thr Ser Arg Arg Trp Leu Asn Leu Gln Glu Tyr Gln Ser Lys Lys Leu 
        35                  40                  45


Met Ser Asp Asn Gly Val Arg Val Gln Arg Phe Phe Val Ala Asp Thr 
    50                  55                  60


Ala Asn Glu Ala Leu Glu Ala Ala Lys Arg Leu Asn Ala Lys Glu Ile 
65                  70                  75                  80


Val Leu Lys Ala Gln Ile Leu Ala Gly Gly Arg Gly Lys Gly Val Phe 
                85                  90                  95


Asn Ser Gly Leu Lys Gly Gly Val His Leu Thr Lys Asp Pro Asn Val 
            100                 105                 110


Val Gly Gln Leu Ala Lys Gln Met Ile Gly Tyr Asn Leu Ala Thr Lys 
        115                 120                 125


Gln Thr Pro Lys Glu Gly Val Lys Val Asn Lys Val Met Val Ala Glu 
    130                 135                 140


Ala Leu Asp Ile Ser Arg Glu Thr Tyr Leu Ala Ile Leu Met Asp Arg 
145                 150                 155                 160


Ser Cys Asn Gly Pro Val Leu Val Gly Ser Pro Gln Gly Gly Val Asp 
                165                 170                 175


Ile Glu Glu Val Ala Ala Ser Asn Pro Glu Leu Ile Phe Lys Glu Gln 
            180                 185                 190


Ile Asp Ile Phe Glu Gly Ile Lys Asp Ser Gln Ala Gln Arg Met Ala 
        195                 200                 205


Glu Asn Leu Gly Phe Val Gly Pro Leu Lys Ser Gln Ala Ala Asp Gln 
    210                 215                 220


Ile Thr Lys Leu Tyr Asn Leu Phe Leu Lys Ile Asp Ala Thr Gln Val 
225                 230                 235                 240


Glu Val Asn Pro Phe Gly Glu Thr Pro Glu Gly Gln Val Val Cys Phe 
                245                 250                 255


Asp Ala Lys Ile Asn Phe Asp Asp Asn Ala Glu Phe Arg Gln Lys Asp 
            260                 265                 270


Ile Phe Ala Met Asp Asp Lys Ser Glu Asn Glu Pro Ile Glu Asn Glu 
        275                 280                 285


Ala Ala Lys Tyr Asp Leu Lys Tyr Ile Gly Leu Asp Gly Asn Ile Ala 
    290                 295                 300


Cys Phe Val Asn Gly Ala Gly Leu Ala Met Ala Thr Cys Asp Ile Ile 
305                 310                 315                 320


Phe Leu Asn Gly Gly Lys Pro Ala Asn Phe Leu Asp Leu Gly Gly Gly 
                325                 330                 335


Val Lys Glu Ala Gln Val Tyr Gln Ala Phe Lys Leu Leu Thr Ala Asp 
            340                 345                 350


Pro Lys Val Glu Ala Ile Leu Val Asn Ile Phe Gly Gly Ile Val Asn 
        355                 360                 365


Cys Ala Ile Ile Ala Asn Gly Ile Thr Lys Ala Cys Arg Glu Leu Glu 
    370                 375                 380


Leu Lys Val Pro Leu Val Val Arg Leu Glu Gly Thr Asn Val Gln Glu 
385                 390                 395                 400


Ala Gln Lys Ile Leu Asn Asn Ser Gly Leu Pro Ile Thr Ser Ala Ile 
                405                 410                 415


Asp Leu Glu Asp Ala Ala Lys Lys Ala Val Ala Ser Val Ala Lys Lys 
            420                 425                 430


<210>  214
<211>  5722
<212>  DNA
<213>  Homo sapiens

<400>  214
atttttaact tcgcaacact tggactattt ctgttgaagt tttctctcct ttccctgcct     60

tcccaacaga acgctgtcct ctactgcagc tgatgcaacc cagccacctc ccggcaatcc    120

gcttacttgc aatcaagggt tcaggtgcaa gcagatgctg actcagcctg ttccattaag    180

agctaagaag caagaagaaa ttggggcgcc atggggaaag cccgcagatc cccgccaggg    240

caccacaggc attgtgaggg atgcttcaac cgccactgcc acattcctgt ggaacccaac    300

acctcctgcc tggtaataag ctgccacctg ctctgtggtg ccaccttcca catgtgcaaa    360

gaggcagagc accagctcct ctgcccttta gagcaggttc cgtgcctcaa ctccgaatat    420

ggctgccctc tgtccatgtc ccgccacaaa ctggccaagc acctgcaggt gtgccccgcc    480

agcgtggtct gctgctccat ggagtggaac cgctggccaa atgtggactc tgaaaccacc    540

cttcatgaaa acatcatgaa agagaccccc agtgaggagt gtttggacac agccctggcc    600

ctgcaggatc agaaggtcct cttcagatcc ttgaaaatgg tggaactttt cccagaaact    660

agagaggcta ctgaggagga accaactatg aatggtgaaa ccagtgtgga ggaaatggga    720

ggagcagtgg gtggagtgga tatcggtttg gtaccacatg gtctgtcagc aactaatggg    780

gagatggcag agctaagtca agaagaacgg gaggtgctag ccaaaaccaa agaagggatg    840

gacctggtca agtttggcca gtgggaaaat attttcagca aagagcacgc agcctctgct    900

ttaacaaatt catcagcgag ctgtgagagc aagaacaaga atgactccga gaaagaacag    960

atttccagtg gccataacat ggtagaagga gagggcgctc ccaaaaagaa agaaccacag   1020

gaaaatcaga agcagcagga cgttcgtaca gccatggaaa ccacagggct tgccccttgg   1080

caggatggtg ttctggaaag actgaaaaca gctgtggatg caaaggacta taacatgtat   1140

ctagtgcaca atgggcggat gctgatacac tttggtcaga tgcctgcttg tacacccaag   1200

gagagagact ttgtttatgg caagctggag gctcaggaag ttaagactgt ttacaccttc   1260

aaagttcctg tgagctactg tggaaagcga gctcgacttg gagatgccat gttgagttgt   1320

aagccaagtg aacacaaggc agtggatact tcagatttgg ggatcactgt ggaggacctg   1380

cccaaatcag atctcatcaa gaccaccctc cagtgtgctt tggaaagaga actcaaaggc   1440

cacgtcatct ctgaatccag aagcattgat ggactgttca tggattttgc cacacaaaca   1500

tacaactttg agccagaaca gttttcctct gggacagtgc tggctgacct aaccgctgcc   1560

accccagggg gactccacgt ggagctccac agcgagtgtg tgaccaggag acacaacaaa   1620

agcagctctg ccttcacttt cacttgcaac aaattcttca ggagggatga gttccccctg   1680

cacttcaaga atgtccacac agacattcag tcatgtctca atggctggtt ccagcatcga   1740

tgccccctcg cctacttggg atgtacattt gttcaaaacc atttccgtcc cccagggcaa   1800

aaggcaaaag taatctatag ccaggagctc aagacctttg ccattaagcc ggaggttgct   1860

ccagagctga gcgagggaag gaagaacaac catcttttgg gtcatggagg aaaaagccag   1920

aattctttaa ccagcctgcc cctggagatt ttgaagtaca ttgctgggtt cttggacagc   1980

gtcagcctgg cccagctctc ccaggtgtct gtgctgatga ggaatatctg tgccactttg   2040

ttacaagaga gaggaatggt ccttttgcaa tggaagaaaa agaggtattc ccatggaggc   2100

acctcctgga gagtccacag agagatctgg cagttcagca gcctcttctc caaaatcaag   2160

agctgggagt ttaatgaagt cacctccatg tctgagcacc tgaagtcctg tcctttcaac   2220

attgtagagc acaaaactga cccgattctt ttgactagca tgtgtcagcc ccgtgagcag   2280

gcccgagaga gcttagtctc cacctttaga atcagaccac gaggaagata cgtctcctaa   2340

aaattcagat gccactcgat gcacccttct tggatttctt ctcggagttc ctgaagtagg   2400

acagagtgtg tggttttgag gactcccttc tgtaaactgc ctatttgctt atcggggtgt   2460

attggaacac gcaatgtcct tcgaaacctc aacacgaggc ctaagaattt cctaagccat   2520

gtcttgtacc atagtgccac attgatgact tgtttccttt tttcttttct tttcttttct   2580

tttttctttc tttctaaaat agattggtct gagaagaaaa taagtaattt gaggccattt   2640

ggaagatggg cccaatttct taagtgatga gagagcacga aattccataa ccagtacagg   2700

cctgtgcttt tacatgggct ttttagttca caaagcactt tcaaatttat gggacaggaa   2760

atgcaggatg ggactcccca gggaacgcag ggtgaaggga acaaagctgg aggctctgga   2820

gctgggtctg ttttgacggt caagtccagg gctcattttg gttattctac tgcctctagg   2880

ccagggtagt cctaacacag cctgacatag gagagcccct ggctgagcat ggcagccttg   2940

aagacaccac aggccaaaac atgaggggca gaaatgggat cacagagtct gttgctagaa   3000

tcttggcaac atacagcagg aaagccttga taaatcggga gtccaaagga gacaccatat   3060

ttatggagaa cattaggaca aaaagtcacc aacttacttt gtaacatttt aataatgact   3120

taagggtcaa gatttttttc ttctgaaaat tatgttctga gttaggcaga acatagccat   3180

ggccctgggc caccctgtgc tatctgaaat gacctcaata cactaatgcc aacctcagcg   3240

tcatgccaga atgcacaggg cagcccaggg agatcacacc tttggcaaag tccagacaag   3300

gcccactgca gttcctatgg cgccagtcac cagctcctag acagcacttg ggtaccccat   3360

tggggtcttg gagaggaaga catgtgaaca taacggctcc ctgaaattgc tcctacccat   3420

ccatatttct ggtcatgctt tcagtctgac aaaaatggat gatactgctg tttttggtaa   3480

caaacagtga atattcataa gaacaaaagt aaaagaaaaa aagacacagt agaaactggc   3540

atcccctaaa gcagggcttc ttagccttgg aactattgac atttttaaat ggataattct   3600

tttttttttt ttctaggtgg ggaggggatg gagttcactc ttgttgccca ggctggagcg   3660

caatgacatg atctcggctc accgcaacct ccgcctcctg ggttcaagcg attctcctgc   3720

ctcagcctcc cgagtagctg ggattactcg cctggctaat tttgtatttt tagtagagac   3780

gggctttctc catgttgttc aggctggtct caaactcccg acctcaggtg actcgcccgc   3840

cttggccttc caaagtgctg ggtttacagg tgtgagccac tgcgccctgc ctgaactgga   3900

taattctttg ttgcaaggga ctgttctgtg tactacagga tacttggcag catccttggc   3960

ctatccatta aatgtcagta gcacccccac agtggcaaca atcaaaaatg tcaccagaca   4020

ttgctaaata ttggggagca aaatggctcc ccgttgaaaa tccctaaagg atgtcatact   4080

agtgacaata agttaggata tgcttatttt ttagtacagc aaaatcttat cgcacatagc   4140

tatccacaat agttatgatt taatgcagct ctttatttat gaaataggtt ttagacatgt   4200

ggtgatttta agttgggaac cagaaggaaa tgattcgttt ggtatggctt catgtccttc   4260

agccaccccc aagaatgtat cctttcagct ctctttggtt atacctgaag ccaggagcgt   4320

tgagttatta gccttgtgtt tatattcctc tcactgtaat tggtgtcatt ttcccagcag   4380

tcctagcagt cctcaagcaa gtgggaaatc ggaaaagaaa aggacaggca ttgtagggaa   4440

gcagaggata aagaatttag ccaacaaaag aaacaatcta gtcaatctgg gtgcttttat   4500

ttcctgggtt ctctctaaac atggctcaga gctggtgtag atgaagtagg tgaaacctct   4560

gaaaagagtc tagaaggcag tagagcaagt cccagaccag aaacatgctc atcttttcat   4620

cgtaatgtgc cactcggtac tatttggtaa tgtcactcta tttttcctaa tcccatcctt   4680

tggtttgtat ttcatatttg tatataaggc accattttct aaaaatatga ctagggtgtg   4740

acctaaggtt ttattctgtg aagatgagta actggaaaga agctaacact gcagtgggaa   4800

ggaaggaaga gagttgtcca ggtggtagtt cgacgtgttt tgaatctagt ccttcctaca   4860

tggaggataa aagctcctaa agtccactct gggtttgtga ttttaataga aatagaaagg   4920

gaaactatag accaatggag atgaaaatca ggggctatcg acagatggag gagaaataag   4980

gtgctacata gagaaaggaa gagggcagaa ggctttccct tcccaaactg ggtgagctgg   5040

ggaagccttg gttcaggaga gtggcactgc ccacaactgc tttgtgggtt gtgcacttcc   5100

agccgcactc tccccctcca gttgctgcct tcagagccgt actgaagcac gagcttcaat   5160

aagacaagca cacttcatag tgagagggca gcggtaccaa agcctttcag agagactatg   5220

gattagacag aaatgatttg tgagaggaag ctggagtgaa cagcatgaac agcgagtgtt   5280

acctgacaga ggcaagacag ctagaagtgg cttcagattt agaaacagct gaggggagca   5340

aagacggact gtgtacacag ggagggagga tgtctatggg cagagccctt ggtgagtatc   5400

atcaccaaga aaggcagtcc agagtagaga tcagccgaat atggaggctg aggtctgtag   5460

aactgggcca gagaggacct tactgcctta gtagcataag ggtctggaaa agaagtttct   5520

atctcacaac aaaggaaaaa gtgaaaagca aggtggaact tgaagatacg tcacgaaaat   5580

cactataaaa gtctgattta tgtgtgatgt caaatcaaac tgaaatgaag aatgagattg   5640

agtatatctg tggtgactga cctctgtata ctagaaacct caacatctct agaagaggaa   5700

ataaaagctg ctttgcactc tg                                            5722


<210>  215
<211>  709
<212>  PRT
<213>  Homo sapiens

<400>  215

Met Gly Lys Ala Arg Arg Ser Pro Pro Gly His His Arg His Cys Glu 
1               5                   10                  15


Gly Cys Phe Asn Arg His Cys His Ile Pro Val Glu Pro Asn Thr Ser 
            20                  25                  30


Cys Leu Val Ile Ser Cys His Leu Leu Cys Gly Ala Thr Phe His Met 
        35                  40                  45


Cys Lys Glu Ala Glu His Gln Leu Leu Cys Pro Leu Glu Gln Val Pro 
    50                  55                  60


Cys Leu Asn Ser Glu Tyr Gly Cys Pro Leu Ser Met Ser Arg His Lys 
65                  70                  75                  80


Leu Ala Lys His Leu Gln Val Cys Pro Ala Ser Val Val Cys Cys Ser 
                85                  90                  95


Met Glu Trp Asn Arg Trp Pro Asn Val Asp Ser Glu Thr Thr Leu His 
            100                 105                 110


Glu Asn Ile Met Lys Glu Thr Pro Ser Glu Glu Cys Leu Asp Thr Ala 
        115                 120                 125


Leu Ala Leu Gln Asp Gln Lys Val Leu Phe Arg Ser Leu Lys Met Val 
    130                 135                 140


Glu Leu Phe Pro Glu Thr Arg Glu Ala Thr Glu Glu Glu Pro Thr Met 
145                 150                 155                 160


Asn Gly Glu Thr Ser Val Glu Glu Met Gly Gly Ala Val Gly Gly Val 
                165                 170                 175


Asp Ile Gly Leu Val Pro His Gly Leu Ser Ala Thr Asn Gly Glu Met 
            180                 185                 190


Ala Glu Leu Ser Gln Glu Glu Arg Glu Val Leu Ala Lys Thr Lys Glu 
        195                 200                 205


Gly Met Asp Leu Val Lys Phe Gly Gln Trp Glu Asn Ile Phe Ser Lys 
    210                 215                 220


Glu His Ala Ala Ser Ala Leu Thr Asn Ser Ser Ala Ser Cys Glu Ser 
225                 230                 235                 240


Lys Asn Lys Asn Asp Ser Glu Lys Glu Gln Ile Ser Ser Gly His Asn 
                245                 250                 255


Met Val Glu Gly Glu Gly Ala Pro Lys Lys Lys Glu Pro Gln Glu Asn 
            260                 265                 270


Gln Lys Gln Gln Asp Val Arg Thr Ala Met Glu Thr Thr Gly Leu Ala 
        275                 280                 285


Pro Trp Gln Asp Gly Val Leu Glu Arg Leu Lys Thr Ala Val Asp Ala 
    290                 295                 300


Lys Asp Tyr Asn Met Tyr Leu Val His Asn Gly Arg Met Leu Ile His 
305                 310                 315                 320


Phe Gly Gln Met Pro Ala Cys Thr Pro Lys Glu Arg Asp Phe Val Tyr 
                325                 330                 335


Gly Lys Leu Glu Ala Gln Glu Val Lys Thr Val Tyr Thr Phe Lys Val 
            340                 345                 350


Pro Val Ser Tyr Cys Gly Lys Arg Ala Arg Leu Gly Asp Ala Met Leu 
        355                 360                 365


Ser Cys Lys Pro Ser Glu His Lys Ala Val Asp Thr Ser Asp Leu Gly 
    370                 375                 380


Ile Thr Val Glu Asp Leu Pro Lys Ser Asp Leu Ile Lys Thr Thr Leu 
385                 390                 395                 400


Gln Cys Ala Leu Glu Arg Glu Leu Lys Gly His Val Ile Ser Glu Ser 
                405                 410                 415


Arg Ser Ile Asp Gly Leu Phe Met Asp Phe Ala Thr Gln Thr Tyr Asn 
            420                 425                 430


Phe Glu Pro Glu Gln Phe Ser Ser Gly Thr Val Leu Ala Asp Leu Thr 
        435                 440                 445


Ala Ala Thr Pro Gly Gly Leu His Val Glu Leu His Ser Glu Cys Val 
    450                 455                 460


Thr Arg Arg His Asn Lys Ser Ser Ser Ala Phe Thr Phe Thr Cys Asn 
465                 470                 475                 480


Lys Phe Phe Arg Arg Asp Glu Phe Pro Leu His Phe Lys Asn Val His 
                485                 490                 495


Thr Asp Ile Gln Ser Cys Leu Asn Gly Trp Phe Gln His Arg Cys Pro 
            500                 505                 510


Leu Ala Tyr Leu Gly Cys Thr Phe Val Gln Asn His Phe Arg Pro Pro 
        515                 520                 525


Gly Gln Lys Ala Lys Val Ile Tyr Ser Gln Glu Leu Lys Thr Phe Ala 
    530                 535                 540


Ile Lys Pro Glu Val Ala Pro Glu Leu Ser Glu Gly Arg Lys Asn Asn 
545                 550                 555                 560


His Leu Leu Gly His Gly Gly Lys Ser Gln Asn Ser Leu Thr Ser Leu 
                565                 570                 575


Pro Leu Glu Ile Leu Lys Tyr Ile Ala Gly Phe Leu Asp Ser Val Ser 
            580                 585                 590


Leu Ala Gln Leu Ser Gln Val Ser Val Leu Met Arg Asn Ile Cys Ala 
        595                 600                 605


Thr Leu Leu Gln Glu Arg Gly Met Val Leu Leu Gln Trp Lys Lys Lys 
    610                 615                 620


Arg Tyr Ser His Gly Gly Thr Ser Trp Arg Val His Arg Glu Ile Trp 
625                 630                 635                 640


Gln Phe Ser Ser Leu Phe Ser Lys Ile Lys Ser Trp Glu Phe Asn Glu 
                645                 650                 655


Val Thr Ser Met Ser Glu His Leu Lys Ser Cys Pro Phe Asn Ile Val 
            660                 665                 670


Glu His Lys Thr Asp Pro Ile Leu Leu Thr Ser Met Cys Gln Pro Arg 
        675                 680                 685


Glu Gln Ala Arg Glu Ser Leu Val Ser Thr Phe Arg Ile Arg Pro Arg 
    690                 695                 700


Gly Arg Tyr Val Ser 
705


<210>  216
<211>  698
<212>  DNA
<213>  Homo sapiens

<400>  216
gctgatggca tctcaccaaa atgcggtgca ataaaagcaa atccttgaag agtggaaacc     60

ttgcagccag gttcatggaa gggctcaaga atattgctgt gctacggtgc ttctgcaggc    120

aggttcacca tctgtgtaac tgtggctacc accttccatc ttgaactcag acacagacct    180

ctcctccgag ctccagatcc atatatccaa tctccttctc aatagtcact tgcaagtctc    240

agccatttca aagtcaaccc aaagtggtaa tcttcaaatc tttcccattt caacaagtga    300

caccaccatc cactaattgt aaaagtcaga aacctggatg ccatctttgc tccactgtga    360

gaggctgctc acaccacccc ctacatgccc tgaggagtct ccaggggcac ccacagcctc    420

ctctggcttt ctctgggtga cccagggagg gctaggccct gtgagccaca ccggggcagc    480

agcactcacc agctcacaag tgcttccctc ttctgccttt gctgacaaca gtcccccagg    540

ccttccattc tccttccgat gaggctgatg tattctgttg cagttggatg cacctacaaa    600

aatcctcttc aaaatcccat cacttcacca ccaaggaatt actaaaatac catgaaggag    660

gtgctcaaag gcgatatggg gcagaggaag gaataagt                            698


<210>  217
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  217

Met Pro Ser Leu Leu His Cys Glu Arg Leu Leu Thr Pro Pro Pro Thr 
1               5                   10                  15


Cys Pro Glu Glu Ser Pro Gly Ala Pro Thr Ala Ser Ser Gly Phe Leu 
            20                  25                  30


Trp Val Thr Gln Gly Gly Leu Gly Pro Val Ser His Thr Gly Ala Ala 
        35                  40                  45


Ala Leu Thr Ser Ser Gln Val Leu Pro Ser Ser Ala Phe Ala Asp Asn 
    50                  55                  60


Ser Pro Pro Gly Leu Pro Phe Ser Phe Arg 
65                  70


<210>  218
<211>  4912
<212>  DNA
<213>  Homo sapiens

<400>  218
acagtagaaa gtcagaaggt cacaaagctt gcagggtaag tgacacaact tgaaactgct     60

tggccctctt taaaaagaaa taataaaatg ggagagaatg aagcaagttt acctaacacg    120

tctttgcaag gtaaaaagat ggcctatcag aaggtccatg cagatcaaag agctccagga    180

cactcacagt acttagacaa tgatgacctt caagccactg cccttgactt agagtgggac    240

atggagaagg aactagagga gtctggtttt gaccaattcc agctagacgg tgctgagaat    300

cagaacctag ggcattcaga gactatagac ctcaatcttg attccattca accagcaact    360

tcacccaaag gaaggttcca gagacttcaa gaagaatctg actacattac ccattataca    420

cgatctgcac caaagagcaa tcgctgcaac ttttgccacg tcttaaaaat actttgcaca    480

gccaccattt tatttatttt tgggattttg ataggttatt atgtacatac aaattgccct    540

tcagatgctc catcttcagg aacagttgat cctcagttat atcaagagat tctcaagaca    600

atccaggcag aagatattaa gaagtctttc agaaatttgg tacaactata taaaaatgaa    660

gatgacatgg aaatttcaaa gaagattaag actcagtgga cctctttggg cctagaagat    720

gtacagtttg taaattactc tgtgctgctt gatctgccag gcccttctcc cagcactgtg    780

actctgagca gcagtggtca atgctttcat cctaatggcc agccttgcag tgaagaagcc    840

agaaaagata gcagccaaga cctgctctat tcatatgcag cctattctgc caaaggaact    900

ctcaaggctg aagtcatcga tgtgagttat ggaatggcag atgatttaaa aaggattagg    960

aaaataaaaa acgtaacaaa tcagatcgca ctcctgaaat taggaaaatt gccactgctt   1020

tataagcttt cctcattgga aaaggctgga tttggaggtg ttcttctgta tatcgatcct   1080

tgtgatttgc caaagactgt gaatcctagc catgatacct tcatggtgtc actgaatcca   1140

ggaggagacc cttctacgcc tggttaccca agtgtcgatg aaagttttag acaaagccga   1200

tcaaacctca cctctctatt agtgcagccc atctctgcac ccctcgttgc aaaactgatc   1260

tcttcgccaa aagctagaac caaaaatgaa gcgtgtagct ctctagagct tccaaataat   1320

gaaataagag tcgtcagcat gcaagttcag acagtcacaa aattgaaaac agttactaat   1380

gttgttggat ttgtaatggg cttgacatct ccagaccggt atatcatagt tggcagccat   1440

catcacactg cacacagtta taatggacaa gaatgggcca gtagtactgc aataatcaca   1500

gcgtttatcc gtgccttgat gtcaaaagtt aagagagggt ggagaccaga ccgaactatt   1560

gttttctgtt cttggggagg aacagctttt ggcaatattg gctcatatga atggggagag   1620

gatttcaaga aggttcttca gaaaaatgtt gtggcttata ttagcctcca cagtcccata   1680

agggggaact ctagtctgta tcctgtagca tcaccatctc ttcagcaact ggtagtagag   1740

aaaaataatt tcaactgtac cagaagagcc cagtgcccag aaaccaatat cagttctata   1800

cagatacaag gtgatgctga ttatttcatc aaccatcttg gagttcccat cgtgcagttt   1860

gcttacgagg acatcaaaac attagagggt ccaagttttc tctccgaggc ccgtttttct   1920

acacgagcaa caaaaattga agaaatggat ccctctttca accttcatga aaccattact   1980

aagctctcag gagaagtgat tttgcaaatt gccaacgaac ctgttctgcc ctttaatgca   2040

cttgatatag ctttagaagt tcaaaacaac cttaaaggtg atcaacccaa cactcatcaa   2100

ctgttagcca tggcgttacg cctgcgggag agtgctgaac tttttcagtc tgatgagatg   2160

cgacctgcta atgatcccaa ggagagagca cccatccgca tccggatgct gaatgacatt   2220

ctccaagaca tggagaaaag ctttctggta aagcaggcac caccaggttt ttatagaaac   2280

atcctctacc accttgatga aaagacaagc cggttttcaa tacttataga ggcttgggaa   2340

cactgcaaac cccttgcatc aaatgagacc cttcaagaag ccctgtcaga ggtgttgaac   2400

agcattaatt cagctcaggt ttacttcaaa gcaggacttg atgtgttcaa gagtgtcttg   2460

gatgggaaga attgagaaaa ctctgagcat ttttaaaagt ttgtttacaa ttccacaagc   2520

aaaagctcta atttaaccag attttctgac attgaaggct tattttcccc aatggctttt   2580

tgacaagtat aaagctatta ttacattgta ttttttaaat gtaaatatag aaagaacatt   2640

ttgcacattt aatatttttc ttatatctac atttctgaat atgtaaagca agttattgaa   2700

ataggactta agaattacct attaaaaaga aatctgatat ataaaaatat gtactatttt   2760

aaggaaaaat ttccaagaag ttctggacta tctttgttcc tatggggagg gcatatagga   2820

acacagttta ttctctctga tagagctatt aatgacttag tttctgtaaa agaaatggag   2880

agttgatatg gttcagatta acttcactat taagtgttca atatgaagaa ttcaagtatt   2940

ctgactgagt gattggttga cctaaaccac tttgaatgtt tctattttat gaaatgaagt   3000

ttctcttctt aacacaacta gatgtagtaa tacactggtt atgaaattgt atttttttaa   3060

gtattaatga aaaaagagcc ataagcattc caggagaaaa tctcaaggga gctacataga   3120

gcaatttaaa tgcaaatttt tttcctaaca acttacaagg tgactagctt tgaaacccct   3180

aatttgcctc agttgatttt ctaagaattt caggagtgat gtatgtctta agagggagaa   3240

aaaaatattt cttattactt tttctcttgt ttctgttgga aacactgaag cagggactct   3300

aaaatgaaag catctcacat tggttttctt tcttgtatct tttctgaaac tccttgctgt   3360

aaggcagctt tctcagagta ctatatattt tcaacagtaa agtagcagag tttctctttg   3420

aaacccaaaa tgtcttctaa agaatcaaat ttctatttct gcctctgaca aaaagaactt   3480

actatgaaag aaatagttgt tttatcaata aaagcccctt aatattatga agaaactttt   3540

catatttttt cttctttatc cttaattgtg actaagatgg aaatctagaa aatattcatg   3600

cttctaagtt tctgcagtgt tactgtaaga gagtgtctcg tctacacttc agttcttctc   3660

tcatgtggaa aactaagctt tttatattga cattgccatt gaatagctct agcaactatt   3720

attattcccc caaaccctaa aattctacct attaggtgtc aggttaaagt tctaatttat   3780

ctttagaaat ttatgtgaaa aatggttttc ctatactgga taaagcaatt ccccttagga   3840

aacatagcct cagagtattt catataaatt ttctctatct aattcaaaca tatctcccca   3900

tgatacaccg ccagagtgac attgcagaca gtctgtgtat gtttaaattt tcacttttta   3960

tggatgagca taaacctagt cttagtttaa aggcaaacta aagttgaggg gaaataatta   4020

atcaatactg attaattgat ttataaggtt caacactgtc taccctaaat aatttttata   4080

tgctcaaggc aaagcaggga atagaggcaa ttagctagat aattcaagca gaaatccatt   4140

ttcatcgaaa ttgcctgtgt gcacatattt ttagatgaaa aatgaaacta ccttacaata   4200

ttattttttt aaccaatgta tttgtttgca aacatttgcc atgttgaaga gtgtgtatag   4260

gaaaggtcta gaaataaata ggcttgtgca tacctaggca ttcatgctct ttcttcctct   4320

tcagagatca tcagaaaaga ggtgggaata cacaagcagg tgcatgtaag cccaaaagct   4380

agaaagcctt atatttaacc aaaggttgat gtgttcattc cagttattca cttacagatg   4440

aaactaaaac aaataaaggc aagctattat cagtttggta gttcattatt ttagaacaaa   4500

tttctaaatt aatttattcc cataacctac aatagcactg agaacagaaa acatgtttct   4560

tcttcatttt gtttaaagat tgcgtaccta ggtaagtcac actgtataga taaaaacctt   4620

cttctgtatt cctcacctct aaattatatg ttatttgcta tttgaaaact gtagttaact   4680

atggtttttt attagtctat taaaagatac gtggagatat taaattatac ctaaagcaga   4740

cgtccaacaa attctgtaca tgctgcttta catctttgca acaaacctct taactagcag   4800

cattatttct atagtgtgat tacctgaggg tgcctccaaa tgtatatcat ttcactcccc   4860

tcccctcccc acccccaata gattcaaata aataaaatcc tgagcaaatt aa           4912


<210>  219
<211>  795
<212>  PRT
<213>  Homo sapiens

<400>  219

Met Gly Glu Asn Glu Ala Ser Leu Pro Asn Thr Ser Leu Gln Gly Lys 
1               5                   10                  15


Lys Met Ala Tyr Gln Lys Val His Ala Asp Gln Arg Ala Pro Gly His 
            20                  25                  30


Ser Gln Tyr Leu Asp Asn Asp Asp Leu Gln Ala Thr Ala Leu Asp Leu 
        35                  40                  45


Glu Trp Asp Met Glu Lys Glu Leu Glu Glu Ser Gly Phe Asp Gln Phe 
    50                  55                  60


Gln Leu Asp Gly Ala Glu Asn Gln Asn Leu Gly His Ser Glu Thr Ile 
65                  70                  75                  80


Asp Leu Asn Leu Asp Ser Ile Gln Pro Ala Thr Ser Pro Lys Gly Arg 
                85                  90                  95


Phe Gln Arg Leu Gln Glu Glu Ser Asp Tyr Ile Thr His Tyr Thr Arg 
            100                 105                 110


Ser Ala Pro Lys Ser Asn Arg Cys Asn Phe Cys His Val Leu Lys Ile 
        115                 120                 125


Leu Cys Thr Ala Thr Ile Leu Phe Ile Phe Gly Ile Leu Ile Gly Tyr 
    130                 135                 140


Tyr Val His Thr Asn Cys Pro Ser Asp Ala Pro Ser Ser Gly Thr Val 
145                 150                 155                 160


Asp Pro Gln Leu Tyr Gln Glu Ile Leu Lys Thr Ile Gln Ala Glu Asp 
                165                 170                 175


Ile Lys Lys Ser Phe Arg Asn Leu Val Gln Leu Tyr Lys Asn Glu Asp 
            180                 185                 190


Asp Met Glu Ile Ser Lys Lys Ile Lys Thr Gln Trp Thr Ser Leu Gly 
        195                 200                 205


Leu Glu Asp Val Gln Phe Val Asn Tyr Ser Val Leu Leu Asp Leu Pro 
    210                 215                 220


Gly Pro Ser Pro Ser Thr Val Thr Leu Ser Ser Ser Gly Gln Cys Phe 
225                 230                 235                 240


His Pro Asn Gly Gln Pro Cys Ser Glu Glu Ala Arg Lys Asp Ser Ser 
                245                 250                 255


Gln Asp Leu Leu Tyr Ser Tyr Ala Ala Tyr Ser Ala Lys Gly Thr Leu 
            260                 265                 270


Lys Ala Glu Val Ile Asp Val Ser Tyr Gly Met Ala Asp Asp Leu Lys 
        275                 280                 285


Arg Ile Arg Lys Ile Lys Asn Val Thr Asn Gln Ile Ala Leu Leu Lys 
    290                 295                 300


Leu Gly Lys Leu Pro Leu Leu Tyr Lys Leu Ser Ser Leu Glu Lys Ala 
305                 310                 315                 320


Gly Phe Gly Gly Val Leu Leu Tyr Ile Asp Pro Cys Asp Leu Pro Lys 
                325                 330                 335


Thr Val Asn Pro Ser His Asp Thr Phe Met Val Ser Leu Asn Pro Gly 
            340                 345                 350


Gly Asp Pro Ser Thr Pro Gly Tyr Pro Ser Val Asp Glu Ser Phe Arg 
        355                 360                 365


Gln Ser Arg Ser Asn Leu Thr Ser Leu Leu Val Gln Pro Ile Ser Ala 
    370                 375                 380


Pro Leu Val Ala Lys Leu Ile Ser Ser Pro Lys Ala Arg Thr Lys Asn 
385                 390                 395                 400


Glu Ala Cys Ser Ser Leu Glu Leu Pro Asn Asn Glu Ile Arg Val Val 
                405                 410                 415


Ser Met Gln Val Gln Thr Val Thr Lys Leu Lys Thr Val Thr Asn Val 
            420                 425                 430


Val Gly Phe Val Met Gly Leu Thr Ser Pro Asp Arg Tyr Ile Ile Val 
        435                 440                 445


Gly Ser His His His Thr Ala His Ser Tyr Asn Gly Gln Glu Trp Ala 
    450                 455                 460


Ser Ser Thr Ala Ile Ile Thr Ala Phe Ile Arg Ala Leu Met Ser Lys 
465                 470                 475                 480


Val Lys Arg Gly Trp Arg Pro Asp Arg Thr Ile Val Phe Cys Ser Trp 
                485                 490                 495


Gly Gly Thr Ala Phe Gly Asn Ile Gly Ser Tyr Glu Trp Gly Glu Asp 
            500                 505                 510


Phe Lys Lys Val Leu Gln Lys Asn Val Val Ala Tyr Ile Ser Leu His 
        515                 520                 525


Ser Pro Ile Arg Gly Asn Ser Ser Leu Tyr Pro Val Ala Ser Pro Ser 
    530                 535                 540


Leu Gln Gln Leu Val Val Glu Lys Asn Asn Phe Asn Cys Thr Arg Arg 
545                 550                 555                 560


Ala Gln Cys Pro Glu Thr Asn Ile Ser Ser Ile Gln Ile Gln Gly Asp 
                565                 570                 575


Ala Asp Tyr Phe Ile Asn His Leu Gly Val Pro Ile Val Gln Phe Ala 
            580                 585                 590


Tyr Glu Asp Ile Lys Thr Leu Glu Gly Pro Ser Phe Leu Ser Glu Ala 
        595                 600                 605


Arg Phe Ser Thr Arg Ala Thr Lys Ile Glu Glu Met Asp Pro Ser Phe 
    610                 615                 620


Asn Leu His Glu Thr Ile Thr Lys Leu Ser Gly Glu Val Ile Leu Gln 
625                 630                 635                 640


Ile Ala Asn Glu Pro Val Leu Pro Phe Asn Ala Leu Asp Ile Ala Leu 
                645                 650                 655


Glu Val Gln Asn Asn Leu Lys Gly Asp Gln Pro Asn Thr His Gln Leu 
            660                 665                 670


Leu Ala Met Ala Leu Arg Leu Arg Glu Ser Ala Glu Leu Phe Gln Ser 
        675                 680                 685


Asp Glu Met Arg Pro Ala Asn Asp Pro Lys Glu Arg Ala Pro Ile Arg 
    690                 695                 700


Ile Arg Met Leu Asn Asp Ile Leu Gln Asp Met Glu Lys Ser Phe Leu 
705                 710                 715                 720


Val Lys Gln Ala Pro Pro Gly Phe Tyr Arg Asn Ile Leu Tyr His Leu 
                725                 730                 735


Asp Glu Lys Thr Ser Arg Phe Ser Ile Leu Ile Glu Ala Trp Glu His 
            740                 745                 750


Cys Lys Pro Leu Ala Ser Asn Glu Thr Leu Gln Glu Ala Leu Ser Glu 
        755                 760                 765


Val Leu Asn Ser Ile Asn Ser Ala Gln Val Tyr Phe Lys Ala Gly Leu 
    770                 775                 780


Asp Val Phe Lys Ser Val Leu Asp Gly Lys Asn 
785                 790                 795


<210>  220
<211>  2321
<212>  DNA
<213>  Homo sapiens

<400>  220
atgaactggc aaagggagga ggacaagaca gggggttctc atgcatatgc ctaccgactt     60

gaccatcgct gtgcaaatgg tgttttccca gtcagaggta ccatcattga tggcatggaa    120

gattttgatg gtctgatgta cgccttactg tttaaggcgg aggctgggcg gggtgggaat    180

ggggtgctgg aggccggcct ggggcacagc gcaggaggca gctacagtgg ctgcagcagc    240

agcagcctga gtgccaggag gcggcagccg tggcagcggg gcagtcggtt gcatggtggc    300

aggcacaggt gtaatggaga ggtaacagag aagacctcct cccttcctag tcagggcatt    360

agcaagactg aatgcttcct gcccccacca gcagcgccag tgaacaccgc aggatggagc    420

atggcagcgg gcttacccag acccccagct ctgaagagat cagtcctact aagtttcctg    480

gactgtaccg cactggccag ccctcacgtc cccatggcat cctccataag cctcctgata    540

tagtgcctga tgatgagaaa gaccatggga agaaaaaagg aaaatttaag aaaaaggaaa    600

agaggactga cggctatgca gcctttcagg aatatagctc tggagatgag gcagaaagtc    660

cttccaaaat gaagaggctc aagggaatcc atgttttcaa gaagcccagc ttttctaaaa    720

agaaagagaa ggattttaaa ataaaacaga aacccaaaga agaaaagcat aaagaagaaa    780

agcacaaaga agaaaaacat aaagagaaga agtcaaaaga cctgacagaa gctgatgttg    840

ttaaacagtg gaaggaaaag aagaaaaaga aaaaccaatt caggagccag aggtgcctca    900

gattgatgtt ccaaatctca aacccatttt tggaattcct ttggctgatg cagtagagag    960

gaccatgatg tatgatggca ttcggctgcc ggccattttc tgtgaatgta tagatcactt   1020

agagaagtat ggcatgatgc gaaggcatct acagagtatc aggaattgaa tcaaaggtgg   1080

atgagctaaa agcagcctat gaccggaagg agtctaccaa cttggaagaa tatgagctta   1140

acactgtagc cagtttgctg aagcagtatt tgtgagacct tccagagaat ttggttacca   1200

aagagcttat gccgagattt gaagaagctt gtgggaggac cacggagact gagaaagtgc   1260

aggaattcca gcgtttactc aaagaactgc cagaatgtaa ctatcttctg atttcttggc   1320

tcattgtgca catggaccat gtcattgcaa atgaactgga aacaaaaatg aataaacaga   1380

acatttctat agtgctcaac ccaactgtgc agatcagcaa ttgagtcctg tatgtgtttt   1440

tcacacatgc gcaagaactc tttggaaatg ttgtactaaa gcaagcgacg aaacctctgc   1500

gatggtctaa catggccacg atgcccacgc tgccagagac ccaggcaggt atcaaggagg   1560

agatcaggag acagggtttt cttttgaatt gtttacatcg atatctgcag tgtgggataa   1620

aggatttatc taaagaagaa agattatgga aagtccaaag aattttgaca gccctcaaaa   1680

gaaaactgag agacgcttaa agacaggagt gtgaaaccaa gattacacaa aagatagcca   1740

gtcttttaaa agaggatgtt tccaaagaag agatgaatga aaatgaagaa gttataaata   1800

ttctccttgc ttgggagaat gagatcctga ctgaatagga ggagctcctg accatggagc   1860

agtttctatg ccggcagact tcctcagaaa aagaagagat gggatgcctc agagccgaga   1920

ttgctgaaat tcagagtcac cagcagcacg gccgaagtga gactgaggag tactcctccg   1980

agagcgagag tgaggatgag gaggagctgc agattattct ggaatattta cagagacaga   2040

acgaagagct ggaaataaag agcaatcatt tgaatcaagc agttcaagag gagcgcgagg   2100

tcatcatcga gctgcgcgta cagttccggc tgctccagat ggagggaacc aaggctgagc   2160

agcaggtgca ggaggaccag gagcctgagt ggcgcggtgg tgccgtccag tcgcccagag   2220

actgtgtcct caggccaaaa gaagctaaag agcagccaaa ggcaggcaaa gagccggtga   2280

agccatcacc cagcagggac aggaaggaga cgtccatctg a                       2321


<210>  221
<211>  5818
<212>  DNA
<213>  Homo sapiens

<400>  221
gcagtgccgt agtagcgggc cacggagata gacagctttg gagctgctga actccgagca     60

cagggtgaag accccggcgc taccaaccac agcctggcag cctggtctcc gcggcaccca    120

ctggggctgc atccccctcc cccgagaggg ctgcgcaggc gggaagacgc ccagaggcca    180

gcttcggtcc cccttctgtc tctcggttcc tctttcctcc caagtaaggg aataaaccgc    240

gaagaaggag cgccccgggc caccgcgcaa ccaagtgttg cctggtgagg aagagccagg    300

acttctgaat ttaccttgaa tacagacagg aggatgttgc ctaaggaata gcagagatct    360

tgtctcatct tctgagaggt gcctgctgct gctgtataca cttgagtgct cccagaagtc    420

tcctgaaagg cttacatcgc aaacctgcaa tgagccaggc cctgggctgg gcctccactt    480

cagcctagtg aacaaaactc catcactgcc ctttagccac tcacataaag tttaaaaatg    540

ggtgaagaac ggtgggtctc cctcactcca gaagaatttg accaactcca gaaatattca    600

gaatattcct ccaagaagat aaaagatgcc ttgactgaat ttaatgaggg tgggagcctc    660

aaacaatatg acccacatga gccgattagc tatgatgtct tcaagctgtt catgagggcg    720

tacctggagg tggaccttcc ccagccactg agcactcacc tcttcctggc cttcagccag    780

aagcccagac acgagacctc tgaccacccg acggagggag ccagcaacag tgaggccaac    840

agcgcagata ctaatataca gaatgcagat aatgccacca aagcagacga ggcctgtgcc    900

cctgatactg aatcaaatat ggctgagaag caagcaccag ctgaagacca agtggctgcg    960

acccccctgg aaccccccgt ccctcggtct tcaagctcgg aatccccagt ggtatacctg   1020

aaggatgttg tgtgctacct gtccctgctg gagacgggga ggcctcagga taagctggag   1080

ttcatgtttc gcctctatga ttcagatgag aacggtctcc tggaccaagc ggagatggat   1140

tgcattgtca accaaatgct gcatattgcc cagtacctgg agtgggatcc cacagagctg   1200

aggcctatat tgaaggagat gctgcaaggg atggactacg accgggacgg ctttgtgtct   1260

ctacaggaat gggtccatgg agggatgacc accatcccat tgctggtcct cctggggatg   1320

gatgactctg gctccaaggg ggatgggcgg cacgcctgga ccatgaagca cttcaagaaa   1380

ccaacctact gcaacttctg ccatatcatg ctcatgggcg tccgcaagca aggcctgtgc   1440

tgcacttact gtaaatacac tgtccacgaa cgctgtgtgt ccagaaacat tcctggttgt   1500

gtcaaaacgt actcaaaagc caaaaggagt ggtgaggtga tgcagcacgc atgggtggaa   1560

gggaactcct ccgtcaagtg tgaccggtgc cacaaaagta tcaagtgcta ccagagtgtc   1620

accgcgcggc actgcgtgtg gtgccggatg acgtttcacc gcaaatgtga attatcaacg   1680

ttgtgtgacg gtggggaact cagagaccac atcttactgc ccacctccat atgccccatc   1740

acccgggaca ggccaggtga gaagtctgat ggctgcgtgt ccgccaaggg cgaacttgtc   1800

atgcagtata agatcatccc caccccgggt acccaccccc tgctggtctt ggtgaacccc   1860

aagagtggag ggagacaagg agaaagaatt cttcggaaat tccactatct gctcaacccc   1920

aaacaagttt tcaacctgga caatgggggg cctactccag ggttgaactt tttccgtgat   1980

actccagact tccgtgtttt ggcctgtggt ggagatggga cagttggctg gattttggat   2040

tgcattgata aggccaactt tgcaaagcat ccaccagtgg ctgtcctgcc tcttggaaca   2100

ggaaatgacc ttgcccgttg tctccgctgg ggaggaggtt atgaaggggg cagcttgaca   2160

aaaatcctga aagacattga gcagagcccc ttggtgatgc tggaccgctg gcatctggaa   2220

gtcatcccca gagaggaagt ggaaaacggg gaccaggtcc catacagcat catgaacaac   2280

tatttctcca ttggtgtgga cgcttccatt gcacacagat tccatgtgat gagagagaaa   2340

catcctgaaa aattcaacag caggatgaag aacaagctgt ggtactttga atttggcacc   2400

tcggagactt ttgcagcgac ctgcaagaaa ctccacgacc acattgagtt ggagtgtgat   2460

ggggttgggg tggacctgag caacatcttc ctggaaggca ttgccattct caacattccc   2520

agcatgtacg gaggcaccaa tctctgggga gaaaacaaga agaaccgggc tgtgatccgg   2580

gaaagcagga agggtgtcac tgaccccaaa gaactgaaat tctgcgttca agacctcagt   2640

gaccagctcc ttgaagtggt ggggctagaa ggagccatgg agatggggca gatctacacc   2700

ggcctgaaga gtgcaggcag gaggctggcc cagtgcgcct ctgtcaccat caggacaaac   2760

aagctgctgc caatgcaagt ggatggagaa ccctggatgc agccatgttg cacgattaaa   2820

attactcaca agaaccaagc gcccatgatg atggggcctc cccagaagag cagcttcttc   2880

tcgttgagaa ggaagagccg ttcaaaagac taaacagtgt gccaaacacc agctaaacca   2940

agagagaaag caagaaacta taatgcacac tcacacacaa tttatgtgca cactcacaca   3000

tgcacacaca cacacacata cacactcttc tctaaccagt ggaagcaaag ccacccttcg   3060

ggaagaaaac gtcaccttgc catacattct gtttcaacag tgggtacacc cctaacagag   3120

ccagtgccaa caaaacattt tgaatggact tagggcccat gaggttgtgg ctggcttagg   3180

cagcaacctc cacattccca caggccttga gcagaatttt ctgagactga agggaaatcc   3240

ccctttcttt ctaccagccc tgcaagtttc ctcatggacg ctcgcgagga gcaggctgca   3300

ggtttcctgc ctatggtgag atcagatgtg gccaagggaa ggagctctgg ttccagagaa   3360

tttgcacaaa gttccctctg tacagagaca aaacggcctc cggctctcag agcataatcc   3420

ttggcagggc tcagcaggcg cacgttggtt tcttggtcgt cctttgagtg acaacttctc   3480

cgtgaacctg ctgaagaggc agaaaggctg tggaaagctg tatttccatt cttgggtttc   3540

tgcgccgtcg gtgggcactt gttattttcc aggaaccttc tcctggtgtc tacatgtttg   3600

cttagaggcg gctccaagag cccccagagc tgcctgcata gcacacctta gatgtggtat   3660

ttattttctt agttctgtga acacctggga gggagagcgg agaaactggg atttattttt   3720

caaattggtg tcataatatt gtgtaaaaag ggaaggaaaa aaaaaaccac ccccagcttc   3780

tttctttttc aagccaaagc gtgtttcctg tttgagttcc aagccctggt ggcagactat   3840

tcctgaaggc agaaaagatg ggaaggaagg aactttgctg gggaaaccag gagacggttc   3900

cctcctgctt ctttgcactc accactccca gagtatgacc tgaaggacct tctgatggtc   3960

ttaacgtgtg tgcgcgcgtg tgtgtgtgtg tgtgcgtgta tatatatata tttagcctat   4020

atatttatat atatatatat ataaatattt atttactgat ggacttttcc tcattggaaa   4080

aaaaaaacat aggtagtatg agacagaaag tggtaaggaa aaagaaggtt ctcactcccc   4140

cactccaccg tttcattgtc aggacgcatc tccctgtggt gatcacaagg gttaagggga   4200

atgaaagtag ctccctatta tgaacgaaga gaccgagaac tcctattctg gatcctcaaa   4260

acaagcatga aagacctgct gggctggatt tactctccca tttgtcagat aagaaaattg   4320

agtctcagaa aagttcagag acttttccat ggtgtcttgg ctaatgcagc ttgagagtag   4380

gtgccgttac aaagatattt aatggagaaa agaacccaca catctcagag tagggtcatt   4440

tctggtcact gaaaagtgag tccacttgga tccaggttgc cagggaggaa caaacgtaca   4500

gcacatgcgt ggatgggata tccccacaca agaaaacgag cgcctcatgc tgcttcccag   4560

aggttctctc tgacctgaat ggaaaagaag ttggtctgag atcgaaggta ctaaacagat   4620

catcagactg aactctccac atgtcacctc atcatggtca tcatagtctc ttagtttgga   4680

aacaaccttg gctgcaggga tgacctcagt ggagagtcac aagaaggact gaggcgtctt   4740

ctgcaagata ctgccagcca ggacagaggg gtctcagcag agctcagtgg gcttcattca   4800

gcaagtgcca gcattaccat cctttcccaa gggcaaggcc atgcagagct tcattgggcc   4860

tccatccctc tctgagattt atcagtggaa acttggaccc acttgatatc gttccactga   4920

gctgcctcta atcttgcatt ggacaggagc tttggacaaa gaagggaata ttaagattgt   4980

gtgtacaaat ggcacttaac tgtgaaggac cacctaggag caagatcttg gaccattctg   5040

ctcaacctaa cagtgcagaa tgctaagtaa ggggaaaacc aggccacctg aagaatatct   5100

ttaatgatgg tattcttggt gatgggacca acaagctcca gaattactac aggtactatc   5160

ttggaagcca cttgtttctg aaactgaggc aggttcaggt ttggggtcac tgattctaag   5220

acatttacag aagttcgtgc atgtgtttca gccatgatcc ccaagattga ggctattgag   5280

acatggcact atcaacaggt gaaattgatt ctcagagact cacaggtctc atgaaggggc   5340

agtgcagaaa atggccctta cctgctgcac cctagtgcac aggacttgca atgttgcttg   5400

agagacatat cccaagtcct tcttagaggc atggagtata acaacttcag tggaattgca   5460

cttccagttt ggtaacctta gtaaatcttg tgttgttgtt taatcgtgcc ttgcaaatca   5520

tcctttaaac actatgactg tggtttcttg tggtggagtc cctcatcata gtgaccctca   5580

tagcaacctc tgaggttagc agagaaggta ttattatctc gatctcaatg aggagaacaa   5640

ggcttaatga ggtttagtga cttctcaaag ccacatggtt agtcagggga gaacctaatc   5700

ccttatttct tatcttattc tgattctggc catgctacaa acatgttctc acctgccccc   5760

catgcttcta ccccaacagc aataaaaact gtaaagcagg aaaaaaaaaa aaaaaaaa     5818


<210>  222
<211>  791
<212>  PRT
<213>  Homo sapiens

<400>  222

Met Gly Glu Glu Arg Trp Val Ser Leu Thr Pro Glu Glu Phe Asp Gln 
1               5                   10                  15


Leu Gln Lys Tyr Ser Glu Tyr Ser Ser Lys Lys Ile Lys Asp Ala Leu 
            20                  25                  30


Thr Glu Phe Asn Glu Gly Gly Ser Leu Lys Gln Tyr Asp Pro His Glu 
        35                  40                  45


Pro Ile Ser Tyr Asp Val Phe Lys Leu Phe Met Arg Ala Tyr Leu Glu 
    50                  55                  60


Val Asp Leu Pro Gln Pro Leu Ser Thr His Leu Phe Leu Ala Phe Ser 
65                  70                  75                  80


Gln Lys Pro Arg His Glu Thr Ser Asp His Pro Thr Glu Gly Ala Ser 
                85                  90                  95


Asn Ser Glu Ala Asn Ser Ala Asp Thr Asn Ile Gln Asn Ala Asp Asn 
            100                 105                 110


Ala Thr Lys Ala Asp Glu Ala Cys Ala Pro Asp Thr Glu Ser Asn Met 
        115                 120                 125


Ala Glu Lys Gln Ala Pro Ala Glu Asp Gln Val Ala Ala Thr Pro Leu 
    130                 135                 140


Glu Pro Pro Val Pro Arg Ser Ser Ser Ser Glu Ser Pro Val Val Tyr 
145                 150                 155                 160


Leu Lys Asp Val Val Cys Tyr Leu Ser Leu Leu Glu Thr Gly Arg Pro 
                165                 170                 175


Gln Asp Lys Leu Glu Phe Met Phe Arg Leu Tyr Asp Ser Asp Glu Asn 
            180                 185                 190


Gly Leu Leu Asp Gln Ala Glu Met Asp Cys Ile Val Asn Gln Met Leu 
        195                 200                 205


His Ile Ala Gln Tyr Leu Glu Trp Asp Pro Thr Glu Leu Arg Pro Ile 
    210                 215                 220


Leu Lys Glu Met Leu Gln Gly Met Asp Tyr Asp Arg Asp Gly Phe Val 
225                 230                 235                 240


Ser Leu Gln Glu Trp Val His Gly Gly Met Thr Thr Ile Pro Leu Leu 
                245                 250                 255


Val Leu Leu Gly Met Asp Asp Ser Gly Ser Lys Gly Asp Gly Arg His 
            260                 265                 270


Ala Trp Thr Met Lys His Phe Lys Lys Pro Thr Tyr Cys Asn Phe Cys 
        275                 280                 285


His Ile Met Leu Met Gly Val Arg Lys Gln Gly Leu Cys Cys Thr Tyr 
    290                 295                 300


Cys Lys Tyr Thr Val His Glu Arg Cys Val Ser Arg Asn Ile Pro Gly 
305                 310                 315                 320


Cys Val Lys Thr Tyr Ser Lys Ala Lys Arg Ser Gly Glu Val Met Gln 
                325                 330                 335


His Ala Trp Val Glu Gly Asn Ser Ser Val Lys Cys Asp Arg Cys His 
            340                 345                 350


Lys Ser Ile Lys Cys Tyr Gln Ser Val Thr Ala Arg His Cys Val Trp 
        355                 360                 365


Cys Arg Met Thr Phe His Arg Lys Cys Glu Leu Ser Thr Leu Cys Asp 
    370                 375                 380


Gly Gly Glu Leu Arg Asp His Ile Leu Leu Pro Thr Ser Ile Cys Pro 
385                 390                 395                 400


Ile Thr Arg Asp Arg Pro Gly Glu Lys Ser Asp Gly Cys Val Ser Ala 
                405                 410                 415


Lys Gly Glu Leu Val Met Gln Tyr Lys Ile Ile Pro Thr Pro Gly Thr 
            420                 425                 430


His Pro Leu Leu Val Leu Val Asn Pro Lys Ser Gly Gly Arg Gln Gly 
        435                 440                 445


Glu Arg Ile Leu Arg Lys Phe His Tyr Leu Leu Asn Pro Lys Gln Val 
    450                 455                 460


Phe Asn Leu Asp Asn Gly Gly Pro Thr Pro Gly Leu Asn Phe Phe Arg 
465                 470                 475                 480


Asp Thr Pro Asp Phe Arg Val Leu Ala Cys Gly Gly Asp Gly Thr Val 
                485                 490                 495


Gly Trp Ile Leu Asp Cys Ile Asp Lys Ala Asn Phe Ala Lys His Pro 
            500                 505                 510


Pro Val Ala Val Leu Pro Leu Gly Thr Gly Asn Asp Leu Ala Arg Cys 
        515                 520                 525


Leu Arg Trp Gly Gly Gly Tyr Glu Gly Gly Ser Leu Thr Lys Ile Leu 
    530                 535                 540


Lys Asp Ile Glu Gln Ser Pro Leu Val Met Leu Asp Arg Trp His Leu 
545                 550                 555                 560


Glu Val Ile Pro Arg Glu Glu Val Glu Asn Gly Asp Gln Val Pro Tyr 
                565                 570                 575


Ser Ile Met Asn Asn Tyr Phe Ser Ile Gly Val Asp Ala Ser Ile Ala 
            580                 585                 590


His Arg Phe His Val Met Arg Glu Lys His Pro Glu Lys Phe Asn Ser 
        595                 600                 605


Arg Met Lys Asn Lys Leu Trp Tyr Phe Glu Phe Gly Thr Ser Glu Thr 
    610                 615                 620


Phe Ala Ala Thr Cys Lys Lys Leu His Asp His Ile Glu Leu Glu Cys 
625                 630                 635                 640


Asp Gly Val Gly Val Asp Leu Ser Asn Ile Phe Leu Glu Gly Ile Ala 
                645                 650                 655


Ile Leu Asn Ile Pro Ser Met Tyr Gly Gly Thr Asn Leu Trp Gly Glu 
            660                 665                 670


Asn Lys Lys Asn Arg Ala Val Ile Arg Glu Ser Arg Lys Gly Val Thr 
        675                 680                 685


Asp Pro Lys Glu Leu Lys Phe Cys Val Gln Asp Leu Ser Asp Gln Leu 
    690                 695                 700


Leu Glu Val Val Gly Leu Glu Gly Ala Met Glu Met Gly Gln Ile Tyr 
705                 710                 715                 720


Thr Gly Leu Lys Ser Ala Gly Arg Arg Leu Ala Gln Cys Ala Ser Val 
                725                 730                 735


Thr Ile Arg Thr Asn Lys Leu Leu Pro Met Gln Val Asp Gly Glu Pro 
            740                 745                 750


Trp Met Gln Pro Cys Cys Thr Ile Lys Ile Thr His Lys Asn Gln Ala 
        755                 760                 765


Pro Met Met Met Gly Pro Pro Gln Lys Ser Ser Phe Phe Ser Leu Arg 
    770                 775                 780


Arg Lys Ser Arg Ser Lys Asp 
785                 790


<210>  223
<211>  3388
<212>  DNA
<213>  Homo sapiens

<400>  223
tgcggcggcg ctgcctggcg tgtgcgcaag gagcgggcgc ggagccggcg ggcgggcgga     60

ggatagcgcg ggcgcggcac ctgcgggccc gagggtctgg ctgtcgcagc gccgggccgc    120

cccgactccg agcggctgct gagatgagtg cagtgtcgca gccccaggct gctcccagcc    180

cgctggagaa gtcgcccagc acggcgatcc tgtgcaacac gtgtgggaat gtgtgcaagg    240

gcgaggtgct gcgggtgcag gacaagtact tccacatcaa gtgcttcgtc tgtaaagcat    300

gtggctgcga cctggccgag ggcggcttct tcgtgcggca gggcgagtac atctgcacgc    360

tggactacca gaggctctac ggcacccgct gcttcagctg cgaccagttc attgagggtg    420

aggtggtgtc ggcgctgggc aagacctacc accccgactg cttcgtgtgt gccgtctgcc    480

ggctgccctt cccccccggg gaccgagtga ccttcaacgg gaaggaatgc atgtgccaga    540

agtgttccct gcccgtatcg gtgggcagca gcgcgcacct gtcccagggc ctccgaagtt    600

gtgggggctg cggcacagaa atcaagaatg gccaggccct ggtagccttg gacaagcact    660

ggcacttggg ctgttttaag tgcaagagct gtgggaagct cctgaatgcc gagtacatca    720

gcaaggatgg gctgccctac tgcgaagctg actatcacgc caagttcggc atccgctgtg    780

acagctgtga gaaatacatc acggggcgcg tgctggaggc cggagagaag cactaccacc    840

cttcctgcgc gctatgtgtc aggtgcggcc agatgtttgc agaaggcgaa gagatgtatc    900

ttcaaggttc ctccatctgg catccggcgt gtcgacaagc agccagaact gaagacagaa    960

acaaggaaac cagaacttcc tcagagagca tcatttctgt ccctgcttcc agcacctcag   1020

ggtctccgag ccgtgtgatt tatgccaagc ttggtggtga gatcctggac tacagggact   1080

tggcagccct tcctaaaagt aaggccatct atgacatcga ccgccccgac atgatctcct   1140

actcacccta catcagccac tctgcagggg acaggcagag ctacggcgag ggggatcagg   1200

atgaccggtc ctacaagcag tgtcggacct ccagcccaag ctccactggg tcggttagcc   1260

tcgggcgcta cactccgacc tcacggtcac cacagcacta cagccgtcca gctgccaggc   1320

gatcggatgg ggaggatgga agcttggacc aggataacag gaagcagaag agcagctggc   1380

tgatgctcaa gggggatgca gacacaagga ccaattctcc agacctggac acccagtcct   1440

tgtcccacag cagcgggacc gacagagacc ctctccaaag gatggcaggg gacagctttc   1500

actcacaata caagatctat ccgtatgact ccctcatcgt cacaaaccga attcgcgtga   1560

aactgcccaa agacgtggac cggacgagac tggagagaca cttgtcgccc gaggagttcc   1620

aggaagtgtt tgggatgagc atcgaggagt ttgaccgcct ggccctctgg aagaggaatg   1680

accttaagaa gaaagccctt ttgttctgac ggctgccagc ctgccccact ggtgtgtgcc   1740

gggcgccgag gccaggggcc cctggcgaga accgcacaca cccctcccac acaccttgct   1800

ctggcttctc tgtgtccatg gggtgggcgg gagggggtcc cccagcaggt gcggcccctg   1860

cacctgccgg cgacactcct gccggtagtt tagggccgag acggctagct tcacgccacc   1920

cttccccgct gtggcttggt gtcagggaga ggctgtagag tggctgtgtc gggcatcaga   1980

tggagcacac aggtggctgc agcccagccc accttcccag cgttctcgag gtgccctggc   2040

cccggtgctg ggcacgtggg ggacagaggt ggccgggacg tgagctgtga ggcttgttga   2100

tgatggttgc tgacaccatc atcgggggtg ggcacacggc ccttcggagc ctgggcagcc   2160

tggcctcaca ggcagactcg cagacggggc agtgagcgtc tgggacagtg ccaagagtgg   2220

ggtgtgtgat ttttgcaggc gtctgtgatg ggtctcttta gggacaaatg tcaacaaggg   2280

acaagacagg gcaccttccg ccagcgcccc tccatgcgct gcgttcctcc tccagatcga   2340

cccctagatg cctacacaat atctttaaag taacacagaa gtttttattt tattaaaaag   2400

tatagcctac ttaaacgcga gatgacatat atagagttta attttacggt ccctccgcag   2460

gggagcggcc tccagcctta ttctccaccg ctcggatctg tgtggtttca gtctgttctt   2520

ggtgtggtcc tcatacacag agctccctgt ctagtttctt ttctttttct tttttctttt   2580

tctcgtcaca caggtaacct taaagacaga cccctctaaa gaacgctttg taaatacatg   2640

tgaggtatag ccaccactgt tttccttgct gttatttttc caagtcttgg ggagaaaaca   2700

tcctcctctg atggccaaag ccctggaatc aagggtttcc acgtaccctg cctaataccc   2760

gacgtagctc ttgatgcacc gtccttgtgc tgtggctggc ggtgtctcag cctgaaacat   2820

aaaccccaca tgccccagga gcgatgtgct ccctgaaaca gacaaccaca cgctgttggg   2880

gagagaagga tggagatagg atggagatag gatggagatg tggctcttct catctttgaa   2940

gccagcaggg catcccggag caggaggctg gccgggctcc ccaagcgaag gcgttggtgt   3000

ctgtcattag gtgtgtgtta gggtgcagca ccggccgtca caggatgctg ataagcgcgc   3060

tgagaggtgg atgaaacacc aaagtctgtt tccccgtccg cagtgggtgt tgcctctttg   3120

tgtgtgtccc gatgttcctg cctgtgagtc ggccttactc cgtttcctta gcgcccatga   3180

cacgccaagt cccgtttcgc actcggcttc tcacccgccc agctcggcta gggaggggga   3240

gtttttagca cctaatatgc ttcctgccat tgcgcaatct gagcctgagc aactggaaac   3300

ccccatttct cattagtgca atgtcatatc tgatcccagg aagcctggaa aataaaagac   3360

gatgcattat aacttgcgga agtacaag                                      3388


<210>  224
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  224

Met Ser Ala Val Ser Gln Pro Gln Ala Ala Pro Ser Pro Leu Glu Lys 
1               5                   10                  15


Ser Pro Ser Thr Ala Ile Leu Cys Asn Thr Cys Gly Asn Val Cys Lys 
            20                  25                  30


Gly Glu Val Leu Arg Val Gln Asp Lys Tyr Phe His Ile Lys Cys Phe 
        35                  40                  45


Val Cys Lys Ala Cys Gly Cys Asp Leu Ala Glu Gly Gly Phe Phe Val 
    50                  55                  60


Arg Gln Gly Glu Tyr Ile Cys Thr Leu Asp Tyr Gln Arg Leu Tyr Gly 
65                  70                  75                  80


Thr Arg Cys Phe Ser Cys Asp Gln Phe Ile Glu Gly Glu Val Val Ser 
                85                  90                  95


Ala Leu Gly Lys Thr Tyr His Pro Asp Cys Phe Val Cys Ala Val Cys 
            100                 105                 110


Arg Leu Pro Phe Pro Pro Gly Asp Arg Val Thr Phe Asn Gly Lys Glu 
        115                 120                 125


Cys Met Cys Gln Lys Cys Ser Leu Pro Val Ser Val Gly Ser Ser Ala 
    130                 135                 140


His Leu Ser Gln Gly Leu Arg Ser Cys Gly Gly Cys Gly Thr Glu Ile 
145                 150                 155                 160


Lys Asn Gly Gln Ala Leu Val Ala Leu Asp Lys His Trp His Leu Gly 
                165                 170                 175


Cys Phe Lys Cys Lys Ser Cys Gly Lys Leu Leu Asn Ala Glu Tyr Ile 
            180                 185                 190


Ser Lys Asp Gly Leu Pro Tyr Cys Glu Ala Asp Tyr His Ala Lys Phe 
        195                 200                 205


Gly Ile Arg Cys Asp Ser Cys Glu Lys Tyr Ile Thr Gly Arg Val Leu 
    210                 215                 220


Glu Ala Gly Glu Lys His Tyr His Pro Ser Cys Ala Leu Cys Val Arg 
225                 230                 235                 240


Cys Gly Gln Met Phe Ala Glu Gly Glu Glu Met Tyr Leu Gln Gly Ser 
                245                 250                 255


Ser Ile Trp His Pro Ala Cys Arg Gln Ala Ala Arg Thr Glu Asp Arg 
            260                 265                 270


Asn Lys Glu Thr Arg Thr Ser Ser Glu Ser Ile Ile Ser Val Pro Ala 
        275                 280                 285


Ser Ser Thr Ser Gly Ser Pro Ser Arg Val Ile Tyr Ala Lys Leu Gly 
    290                 295                 300


Gly Glu Ile Leu Asp Tyr Arg Asp Leu Ala Ala Leu Pro Lys Ser Lys 
305                 310                 315                 320


Ala Ile Tyr Asp Ile Asp Arg Pro Asp Met Ile Ser Tyr Ser Pro Tyr 
                325                 330                 335


Ile Ser His Ser Ala Gly Asp Arg Gln Ser Tyr Gly Glu Gly Asp Gln 
            340                 345                 350


Asp Asp Arg Ser Tyr Lys Gln Cys Arg Thr Ser Ser Pro Ser Ser Thr 
        355                 360                 365


Gly Ser Val Ser Leu Gly Arg Tyr Thr Pro Thr Ser Arg Ser Pro Gln 
    370                 375                 380


His Tyr Ser Arg Pro Ala Ala Arg Arg Ser Asp Gly Glu Asp Gly Ser 
385                 390                 395                 400


Leu Asp Gln Asp Asn Arg Lys Gln Lys Ser Ser Trp Leu Met Leu Lys 
                405                 410                 415


Gly Asp Ala Asp Thr Arg Thr Asn Ser Pro Asp Leu Asp Thr Gln Ser 
            420                 425                 430


Leu Ser His Ser Ser Gly Thr Asp Arg Asp Pro Leu Gln Arg Met Ala 
        435                 440                 445


Gly Asp Ser Phe His Ser Gln Tyr Lys Ile Tyr Pro Tyr Asp Ser Leu 
    450                 455                 460


Ile Val Thr Asn Arg Ile Arg Val Lys Leu Pro Lys Asp Val Asp Arg 
465                 470                 475                 480


Thr Arg Leu Glu Arg His Leu Ser Pro Glu Glu Phe Gln Glu Val Phe 
                485                 490                 495


Gly Met Ser Ile Glu Glu Phe Asp Arg Leu Ala Leu Trp Lys Arg Asn 
            500                 505                 510


Asp Leu Lys Lys Lys Ala Leu Leu Phe 
        515                 520


<210>  225
<211>  2240
<212>  DNA
<213>  Homo sapiens

<400>  225
acttccccgc cctcgcccca aaggagcagc agctccttct tgcctctcca ttgccgccgc     60

cgcaccggcg gagctcctct ctcgcgcgtc tctcctccga tggagctcgg gcgccgccga    120

cgccgccgct gccccgaacc ctgagcgggg ccgccccggt cggaggaacg cgccgcccag    180

tccgagggcg cagagcgcca ggagcacgcg gagggctggg gcgcgggctc cgggaacgag    240

aaagtgcagc tctctcgggt cactgggccg gcggcggggg gactatggct ctgaaggaca    300

cgggcagcgg cggcagcacc atcctgccca ttagcgagat ggtttcctcg tccagctcgc    360

ccggcgcgtc ggccgccgcc gccccggggc cctgcgcacc ctcgcccttc cctgaagtag    420

tggagctgaa cgtaggcggc caggtttatg tgaccaagca ctcgacgctg ctcagcgtcc    480

cggacagtac tttggccagc atgttctcgc cctctagtcc ccgtggcggc gcccggcgcc    540

ggggcgagct gcccagggac agccgggcgc gcttcttcat cgaccgggac ggcttccttt    600

tcaggtacgt gctggattat ctgcgggaca agcaactcgc gctgccggag cacttccccg    660

agaaggagcg gctgctgcgc gaggccgagt atttccagct caccgacttg gtcaagctgc    720

tgtcgcccaa ggtcaccaag cagaactctc tcaacgacga gggctgccag agcgacctgg    780

aggacaacgt ctcgcagggt agcagcgacg cgctgctgct gcgcggggcg gcggccgccg    840

tgccctcggg cccgggagcg cacggtggtg gcggcggcgg cggcgcgcag gacaagcgct    900

cgggcttcct cacgctgggc taccggggct cctacaccac cgtgcgcgac aaccaggccg    960

acgccaaatt ccggcgtgtg gcgcgcatca tggtgtgcgg gcgcatcgcg ctggccaagg   1020

aggtcttcgg ggacacgctc aacgagagcc gcgaccccga ccggcagccg gagaagtaca   1080

cgtcccgctt ctacctcaag ttcacctact tggagcaggc ctttgatcgc ctgtccgagg   1140

ccggcttcca catggtggcg tgtaactcct cgggcaccgc cgccttcgtc aaccagtacc   1200

gcgacgacaa gatctggagc agctacaccg agtacatttt cttccgacca cctcagaaaa   1260

tagtatcacc taaacaagaa catgaagata ggaaacatga caaagtcact gataaaggaa   1320

gtgaaagtgg gacttcctgt aatgagctct ccacttccag ttgtgacagc cattcagagg   1380

caagcactcc ccaggacaac ccatccagtg cccagcaggc aacagctcac caacctaaca   1440

ctttaacatt ggatcgcccc tctaaaaaag cacctgtaca atggataccc ccaccagaca   1500

aacgcagaaa cagtgaactc tttcagaccc tcatcagcaa gtcccgggaa acaaatctgt   1560

ccaaaaagaa agtctgtgag aagctaagtg tggaagaaga aatgaaaaag tgtattcagg   1620

attttaaaaa aatccacatt ccagattatt ttccagagcg caaacgccaa tggcaatctg   1680

aactgttgca gaagtatggg ttatagtaat tgtcacattc ctgcagtatt ttgatgacat   1740

tcaatgttta ctacagtgtc accacctgac tgatgtccta acaatggtca gtgtgattct   1800

tgctgctctt ccttgttgtg aacagtggat gtgggacagt attttctttt atgttttagt   1860

tgttgttctt tttagaaaca tgattaaaaa ggaaaaaata ttaaatcaat aagtgttaaa   1920

tcaaaatgga atatctgatt caaaccattt tacaagaatg aaagtaaaat gtgcatgatc   1980

aagcttagta tcttggtttt tgaactctgg tcaactggat atgtttgtca ttttgtaact   2040

taccaaaaac aaaccatcat atcataccaa ctaaaatgat atatggatga agcaacatca   2100

agtaaaattt tagacgatgg ctataggacc caaatctaaa gctgtctaaa tgttaattca   2160

atgaaacaag tattattttt gcatgaatac aatgttacaa ataaatcaca agaaataggg   2220

aagatctgtt tgttgcttgg                                               2240


<210>  226
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  226

Met Ala Leu Lys Asp Thr Gly Ser Gly Gly Ser Thr Ile Leu Pro Ile 
1               5                   10                  15


Ser Glu Met Val Ser Ser Ser Ser Ser Pro Gly Ala Ser Ala Ala Ala 
            20                  25                  30


Ala Pro Gly Pro Cys Ala Pro Ser Pro Phe Pro Glu Val Val Glu Leu 
        35                  40                  45


Asn Val Gly Gly Gln Val Tyr Val Thr Lys His Ser Thr Leu Leu Ser 
    50                  55                  60


Val Pro Asp Ser Thr Leu Ala Ser Met Phe Ser Pro Ser Ser Pro Arg 
65                  70                  75                  80


Gly Gly Ala Arg Arg Arg Gly Glu Leu Pro Arg Asp Ser Arg Ala Arg 
                85                  90                  95


Phe Phe Ile Asp Arg Asp Gly Phe Leu Phe Arg Tyr Val Leu Asp Tyr 
            100                 105                 110


Leu Arg Asp Lys Gln Leu Ala Leu Pro Glu His Phe Pro Glu Lys Glu 
        115                 120                 125


Arg Leu Leu Arg Glu Ala Glu Tyr Phe Gln Leu Thr Asp Leu Val Lys 
    130                 135                 140


Leu Leu Ser Pro Lys Val Thr Lys Gln Asn Ser Leu Asn Asp Glu Gly 
145                 150                 155                 160


Cys Gln Ser Asp Leu Glu Asp Asn Val Ser Gln Gly Ser Ser Asp Ala 
                165                 170                 175


Leu Leu Leu Arg Gly Ala Ala Ala Ala Val Pro Ser Gly Pro Gly Ala 
            180                 185                 190


His Gly Gly Gly Gly Gly Gly Gly Ala Gln Asp Lys Arg Ser Gly Phe 
        195                 200                 205


Leu Thr Leu Gly Tyr Arg Gly Ser Tyr Thr Thr Val Arg Asp Asn Gln 
    210                 215                 220


Ala Asp Ala Lys Phe Arg Arg Val Ala Arg Ile Met Val Cys Gly Arg 
225                 230                 235                 240


Ile Ala Leu Ala Lys Glu Val Phe Gly Asp Thr Leu Asn Glu Ser Arg 
                245                 250                 255


Asp Pro Asp Arg Gln Pro Glu Lys Tyr Thr Ser Arg Phe Tyr Leu Lys 
            260                 265                 270


Phe Thr Tyr Leu Glu Gln Ala Phe Asp Arg Leu Ser Glu Ala Gly Phe 
        275                 280                 285


His Met Val Ala Cys Asn Ser Ser Gly Thr Ala Ala Phe Val Asn Gln 
    290                 295                 300


Tyr Arg Asp Asp Lys Ile Trp Ser Ser Tyr Thr Glu Tyr Ile Phe Phe 
305                 310                 315                 320


Arg Pro Pro Gln Lys Ile Val Ser Pro Lys Gln Glu His Glu Asp Arg 
                325                 330                 335


Lys His Asp Lys Val Thr Asp Lys Gly Ser Glu Ser Gly Thr Ser Cys 
            340                 345                 350


Asn Glu Leu Ser Thr Ser Ser Cys Asp Ser His Ser Glu Ala Ser Thr 
        355                 360                 365


Pro Gln Asp Asn Pro Ser Ser Ala Gln Gln Ala Thr Ala His Gln Pro 
    370                 375                 380


Asn Thr Leu Thr Leu Asp Arg Pro Ser Lys Lys Ala Pro Val Gln Trp 
385                 390                 395                 400


Ile Pro Pro Pro Asp Lys Arg Arg Asn Ser Glu Leu Phe Gln Thr Leu 
                405                 410                 415


Ile Ser Lys Ser Arg Glu Thr Asn Leu Ser Lys Lys Lys Val Cys Glu 
            420                 425                 430


Lys Leu Ser Val Glu Glu Glu Met Lys Lys Cys Ile Gln Asp Phe Lys 
        435                 440                 445


Lys Ile His Ile Pro Asp Tyr Phe Pro Glu Arg Lys Arg Gln Trp Gln 
    450                 455                 460


Ser Glu Leu Leu Gln Lys Tyr Gly Leu 
465                 470


<210>  227
<211>  6769
<212>  DNA
<213>  Homo sapiens

<400>  227
aattctgctg ggagtcgcat cctacctgtt tgggaggtgc actgcctttc cacactctcc     60

cttctgtact cagccagctg ctgctgaggt gggaggaaaa gtcctggctg ggagaattga    120

gctagtgcag cacacgtaaa aaagcgattc cgatgggtcc tttgaaagct tttctcttct    180

ccccttttct tctgcggagt caaagtagag gggtgaggtt ggtcttcttg ttactgaccc    240

tgcatttggg aaactgtgtt gataaggcag atgatgaaga tgatgaggat ttaacggtga    300

acaaaacctg ggtcttggcc ccaaaaattc atgaaggaga tatcacacaa attctgaatt    360

cattgcttca aggctatgac aataaacttc gtccagatat aggagtgagg cccacagtaa    420

ttgaaactga tgtttatgta aacagcattg gaccagttga tccaattaat atggaatata    480

caatagatat aatttttgcc caaacctggt ttgacagtcg tttaaaattc aatagtacca    540

tgaaagtgct tatgcttaac agtaatatgg ttggaaaaat ttggattcct gacactttct    600

tcagaaactc aagaaaatct gatgctcact ggataacaac tcctaatcgt ctgcttcgaa    660

tttggaatga tggacgagtt ctgtatactc taagattgac aattaatgca gaatgttatc    720

ttcagcttca taactttccc atggatgaac attcctgtcc actggaattt tcaagctatg    780

gataccctaa aaatgaaatt gagtataagt ggaaaaagcc ctccgtagaa gtggctgatc    840

ctaaatactg gagattatat cagtttgcat ttgtagggtt acggaactca actgaaatca    900

ctcacacgat ctctggggat tatgttatca tgacaatttt ttttgacctg agcagaagaa    960

tgggatattt cactattcag acctacattc catgcattct gacagttgtt ctttcttggg   1020

tgtctttttg gatcaataaa gatgcagtgc ctgcaagaac atcgttgggt atcactacag   1080

ttctgactat gacaaccctg agtacaattg ccaggaagtc tttacctaag gtttcttatg   1140

tgactgcgat ggatctcttt gtttctgttt gtttcatttt tgtttttgca gccttgatgg   1200

aatatggaac cttgcattat tttaccagca accaaaaagg aaagactgct actaaagaca   1260

gaaagctaaa aaataaagcc tcgatgactc ctggtctcca tcctggatcc actctgattc   1320

caatgaataa tatttctgtg ccgcaagaag atgattatgg gtatcagtgt ttggagggca   1380

aagattgtgc cagcttcttc tgttgctttg aagactgcag aacaggatct tggagggaag   1440

gaaggataca catacgcatt gccaaaattg actcttattc tagaatattt ttcccaaccg   1500

cttttgccct gttcaacttg gtttattggg ttggctatct ttacttataa aatctacttc   1560

ataagcaaaa atcaaaagaa gtctgactaa attcagtaga atcttttgtg cttcagtaac   1620

ttgaagttta aatttaaaat gcagagagac caatggttaa aatgtgaata gtattgtaac   1680

tattttaagg ccttcagaag taaataaagt agcagctttc aggctaattt acgtgaaact   1740

gattagttgc aaaatccagt aggttaaaat actcacatat ttttacttaa attttcttta   1800

atttacttat atgttattat aattttgaat ttttaagttc tatgattcat gttttaaaga   1860

tggaataatt ttaatacata ttttgtttaa atataatcta taattgtttt gtaatgtaag   1920

actaattact aatatttatg tagcaacttt tgtgccagaa aaaagactgt taatttgttt   1980

tttcttgctt ttcatttgat taccctgctt gaaatacagt tagttgataa cataaagcca   2040

tagttttctt ggattttctt ccaagatatt gtattcccaa gaagaaattg atttattttt   2100

aaactatcag ttactgaaga cttatgaaaa ggtcaatttt tacctgtctt ttaatccagt   2160

ccattttctg acacaatatt aaacagaacg ccagttgcat ttactttggt gatttgcaaa   2220

cttggaatga agccaccagt cattttttaa gaatgcaaga tgaaaaaatc aggtaaaatc   2280

taaccatttt attctctgct tcatagcatt tataatgtat gatgaggtta acactgaaat   2340

attaaaatct gcaaatgcac attaatgcaa attaaatgca gagagaaatg attatttttt   2400

tctttatgtt ttatgaaagt gttgcagtcc ctaaaataaa aatattgagg aacattgctt   2460

gtatttactc acgtggttaa aaaattatta cctggcaaac tgagttgccg gtcatattga   2520

ggacaaaatc ttaaatatgt gctattagca ttgtttttag actagtaata tgcagaaaac   2580

agttttaggc ctgcgttaca tattgcctct tccagctcca aagttttgga ccctgtcagt   2640

tttgcaacta cattatacat tattataata ttcttttttt tttctagaaa ctgggggcag   2700

cctcaaaatc atgttaaaga gggagttttg ttagaggcat ctttaatgaa catgaatgtg   2760

agtgctctct aaattcttag catctcactg gatgtaaaat ctatcagtta atagttttaa   2820

aaatgtctct tttgttaaga ataaatttag gcttcaatca ttataatcct gtaagtagct   2880

tgacatacca attgtttata agattcatca cataaatttc tggagaacca ccaggtttag   2940

cttggaaata acctttaaag attgtttctg ttgccaagac caatgaccat gatgaagagt   3000

tttatgatca cagcctatct tacttaaggt ttgagaggaa acctgtcacc tctgcaattg   3060

ttactctagt ttttaatgtt ataattccgc tgcgtggtta gtgaatgtct ggcatgatta   3120

tacacgtgta ttggaaatat ctagtttttt aaatttttaa ttaatttatt tataatttac   3180

tgtgtgttcc cagctaactc tatttttttt ttcacttgct cataaacttc tggaaaaaaa   3240

taagcatgaa tcaaatggta atgcccaata tccaccgaca ctgcttttct tgaatgaaca   3300

gccaaactaa actttggcca tctatatatt catttacaga ttattcatac attcatttta   3360

ataacattga gtactgatgg atgttttgaa agtgagcatt catttaagga taaataaaaa   3420

ataaagtagt aataaagaat aaaatacttt actaaaatat tgtatggcta ttttcatgtt   3480

tgaagctata gcttactatc atgagacagt tttgattttg ggactctttc aagtgtatct   3540

gagcatgact gtattttaaa atacttaaaa gtgcttgata taaatagctt ttccttctga   3600

accacgttct atgtaaaaga aaaaaaatag ctttgatttt ctcactggtg tttcattaac   3660

ttggttttaa atgttgacaa tatttacaag tggaaataaa atttgtaaat atatgaaaga   3720

tgcctttcct tgtatatacc atcaagcaag cactttgttt tcaaagcaag tggtattttg   3780

atcagtttta tttaaatgtg tgatcagaaa gaatggcgta caaatcttat tatttctaaa   3840

aataagaata aaaaggtaaa actacattta gacttctttc tcaagaaatc aaatacagct   3900

ttttttcaaa gctgattcag ttcatttcct gttcctctat tccaagtata agtttcacca   3960

ccttgagaaa taattttttt aaaaaatctt cctctttctc tggggagtta tataataatt   4020

tattgaattt attggaactt gattttcctg gatgctttca atgtttttaa tgctaacata   4080

gaccccaaaa ttagatataa agaattggga aggatacctg gagcacaagg aataagatca   4140

tttgtaaaaa tgtttgttta tatagaccta tcctctaaat atgtgacaag gatctagaaa   4200

ttctgagagg ggaaaatgtg attttggatt tacaatgaca gggtaatatt ttatttatct   4260

tcgaattcca tggacaaaat taggctcact taaattaatt tttgtaaacc caagtaagtt   4320

ctaaaaaaaa gtaaaaaata catagaatac ttgagaattt agcagggaca gggaaaaatt   4380

tcccagtaag tctgaagtct tgatgtaagt gggaattaga taactaattg gaggcatttt   4440

attttaagtt aaagacagat ttctttaata agtttttaaa attgatcaac tttaaattaa   4500

gcacagtaaa tgtgtataaa tatgaaggca atcataagga ttttttcact tgtgtttcca   4560

tattctggca ttagtatatc atcataaaat agacaatgtt tttgtctcaa gaacaagaat   4620

aaaattgaaa tctgcattca tgccaattca gcataaaaaa gaataggcta cagttctctc   4680

acaccaaggg ccccatagtt ataaatgtga aattatattc caggtcaaaa tttgtgaaaa   4740

atacacaaaa cactttgatt ttacaagaga ggagctttaa ataagatgat tttagtagat   4800

tgaaataaat aaccagtatt taagtaaatg tataacgaat gaataaatac atgcataata   4860

ttttcaaagt tctataccag tacctatttt tactcttaca aaatttcctg taaaaaaata   4920

ctacatttga aattatttca ttggttttag aactggcatt gaaggtaccc agtagactct   4980

taagccttta ctgcttgtct cactagaaac atttatttct gacctaccaa gttttcttca   5040

catcatcaaa tttattcagc ttctcagtgc tgtaccgtat gatggcaaga catacttggt   5100

atttccattt ttgttggtca ttctttattg ctttttactg ctaggaaggt cttgccaggc   5160

ttctatacag ttacaaaaac cattaccaaa ctttatcaag gactttccaa atggagtttt   5220

caaatactat tgaccacatt gctctagtta atgtaaggtc agctctgact ttttgtgttt   5280

gcatttcgga agtgaggtaa cctcattcaa atatatatgc agcactttct gtgtacaaag   5340

tactgttcta aatacaaaag ggaatataaa gatgactttc aaggaacata taatgtagtc   5400

agaaagatga gaggattagt tatacaattt aaggaaggga ggataacttt gggaaggttt   5460

tgtggaggat atgtgtttag agatgcgagc tggggattca acaggtaaga gggagagaga   5520

tcacaatttc caactgggta aacagcttga aaaaagaaac agaagcctgg gcacaaatga   5580

aaattccata ttaattggaa gttaagattc atatagagac aatgaaaggt taggttagaa   5640

caataaactg agaagtacga atgtggactt caggaggcta ggggaaatta cgaagtcata   5700

aaaagttcac agagatactt gagtacaaaa gatacattat taaaatttct gcagaagttt   5760

catcttattt gtgtgtgatg gtttggaata taacaagcca gttaggcgta taagcttata   5820

gtggctaata tgaggatgaa atccgtactc ttgtgacaca agtcttcagc ggagatgggg   5880

gatgataggc ccaaatagaa agaaaagtgg cagacattaa gctttgacta acagacaaca   5940

taactgagag acatggtgtg ttgggtggaa gggatcctgt agtagatact tgcttgcatg   6000

tagatgggta caaagacacc ataaggaaat tctgaatgta atacaaaggc ttatttttcc   6060

tgttgattta tctttttcac acataaaaga tgaagaaaaa aataatctga aatgtaaatc   6120

ctaaagtgat ctgtctagat tcttattttt tgaaaaatgt tcctcactaa aagagttttc   6180

tattcaaata accatttcca gttttctaac tgagacatac atacatatat atatgtataa   6240

aattatatat atatttggac aaagagaata agagaattgc aggtagaaat agtctactgt   6300

gtgtagacaa atccagaaag ttgatttctg ttcctcaaac aatttctgaa atatttatgt   6360

cagaataaat aaaagaattg ttattgttgg acaatgaaac atacctggac cctttgagtg   6420

tgtgaatagt aaaggctgtg ataactgaaa tgcagctaag caaaaagggc taattagaag   6480

acttttgaga catgatttac ctaaatggaa atagtttggt tttcaatcct tcactgtaat   6540

aacaattatt tgcatctatt aagtgtttgt agtcactttg tataataaag ttttatggct   6600

tgtgattata atggcttctg ttattctgct actgcctcat tgttttgagg aacatttgta   6660

attttgtggc aaaggtgtct caatttttca gtgttcttta ctctcatgat ccttagaaca   6720

aaaaaaatac cagtaacttg ttataaataa agagtcacat tctcttaaa               6769


<210>  228
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  228

Met Gly Pro Leu Lys Ala Phe Leu Phe Ser Pro Phe Leu Leu Arg Ser 
1               5                   10                  15


Gln Ser Arg Gly Val Arg Leu Val Phe Leu Leu Leu Thr Leu His Leu 
            20                  25                  30


Gly Asn Cys Val Asp Lys Ala Asp Asp Glu Asp Asp Glu Asp Leu Thr 
        35                  40                  45


Val Asn Lys Thr Trp Val Leu Ala Pro Lys Ile His Glu Gly Asp Ile 
    50                  55                  60


Thr Gln Ile Leu Asn Ser Leu Leu Gln Gly Tyr Asp Asn Lys Leu Arg 
65                  70                  75                  80


Pro Asp Ile Gly Val Arg Pro Thr Val Ile Glu Thr Asp Val Tyr Val 
                85                  90                  95


Asn Ser Ile Gly Pro Val Asp Pro Ile Asn Met Glu Tyr Thr Ile Asp 
            100                 105                 110


Ile Ile Phe Ala Gln Thr Trp Phe Asp Ser Arg Leu Lys Phe Asn Ser 
        115                 120                 125


Thr Met Lys Val Leu Met Leu Asn Ser Asn Met Val Gly Lys Ile Trp 
    130                 135                 140


Ile Pro Asp Thr Phe Phe Arg Asn Ser Arg Lys Ser Asp Ala His Trp 
145                 150                 155                 160


Ile Thr Thr Pro Asn Arg Leu Leu Arg Ile Trp Asn Asp Gly Arg Val 
                165                 170                 175


Leu Tyr Thr Leu Arg Leu Thr Ile Asn Ala Glu Cys Tyr Leu Gln Leu 
            180                 185                 190


His Asn Phe Pro Met Asp Glu His Ser Cys Pro Leu Glu Phe Ser Ser 
        195                 200                 205


Tyr Gly Tyr Pro Lys Asn Glu Ile Glu Tyr Lys Trp Lys Lys Pro Ser 
    210                 215                 220


Val Glu Val Ala Asp Pro Lys Tyr Trp Arg Leu Tyr Gln Phe Ala Phe 
225                 230                 235                 240


Val Gly Leu Arg Asn Ser Thr Glu Ile Thr His Thr Ile Ser Gly Asp 
                245                 250                 255


Tyr Val Ile Met Thr Ile Phe Phe Asp Leu Ser Arg Arg Met Gly Tyr 
            260                 265                 270


Phe Thr Ile Gln Thr Tyr Ile Pro Cys Ile Leu Thr Val Val Leu Ser 
        275                 280                 285


Trp Val Ser Phe Trp Ile Asn Lys Asp Ala Val Pro Ala Arg Thr Ser 
    290                 295                 300


Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Leu Ser Thr Ile Ala 
305                 310                 315                 320


Arg Lys Ser Leu Pro Lys Val Ser Tyr Val Thr Ala Met Asp Leu Phe 
                325                 330                 335


Val Ser Val Cys Phe Ile Phe Val Phe Ala Ala Leu Met Glu Tyr Gly 
            340                 345                 350


Thr Leu His Tyr Phe Thr Ser Asn Gln Lys Gly Lys Thr Ala Thr Lys 
        355                 360                 365


Asp Arg Lys Leu Lys Asn Lys Ala Ser Met Thr Pro Gly Leu His Pro 
    370                 375                 380


Gly Ser Thr Leu Ile Pro Met Asn Asn Ile Ser Val Pro Gln Glu Asp 
385                 390                 395                 400


Asp Tyr Gly Tyr Gln Cys Leu Glu Gly Lys Asp Cys Ala Ser Phe Phe 
                405                 410                 415


Cys Cys Phe Glu Asp Cys Arg Thr Gly Ser Trp Arg Glu Gly Arg Ile 
            420                 425                 430


His Ile Arg Ile Ala Lys Ile Asp Ser Tyr Ser Arg Ile Phe Phe Pro 
        435                 440                 445


Thr Ala Phe Ala Leu Phe Asn Leu Val Tyr Trp Val Gly Tyr Leu Tyr 
    450                 455                 460


Leu 
465


<210>  229
<211>  2189
<212>  DNA
<213>  Homo sapiens

<400>  229
cctagcgctc ctctccggct tccaccagcc catcgctcca cgctctcttg gctgctgcag     60

tctcggtctc tctctctctc tctctctctc tctctctctc tctctctctc tctctctctc    120

tctctctctc tctctcccaa gtttcctatc tcgtcaagat cagggcaaaa gaagaaaaca    180

ccgaattctg cttgccgttt cagagcggcg gtgatgaaga caaaattgaa catctacaac    240

atcgagttcc tgctttttgt tttcttggtg tgggaccctg ccaggttggt gctggctaac    300

atccaagaag atgaggctaa aaataacatt accatcttta cgagaattct tgacagactt    360

ctggatggtt acgataatcg gcttagacca ggactgggag acagtattac tgaagtcttc    420

actaacatct acgtgaccag ttttggccct gtctcagata cagatatgga atatacaatt    480

gatgttttct ttcgacaaaa atggaaagat gaacgtttaa aatttaaagg tcctatgaat    540

atccttcgac taaacaattt aatggctagc aaaatctgga ctccagatac cttttttcac    600

aatgggaaga aatcagtagc tcataatatg acaatgccaa ataagttgct tcgaattcag    660

gatgatggga ctctgctgta taccatgagg cttacagttc aagctgaatg cccaatgcac    720

ttggaggatt tcccaatgga tgctcattca tgtcctctga aatttggcag ctatgcatat    780

acaacttcag aggtcactta tatttggact tacaatgcat ctgattcagt acaggttgct    840

cctgatggct ctaggttaaa tcaatatgac ctgctgggcc aatcaatcgg aaaggagaca    900

attaaatcca gtacaggtga atatactgta atgacagctc atttccacct gaaaagaaaa    960

attgggtatt ttgtgattca aacctatctg ccttgcatca tgactgtcat tctctcccaa   1020

gtttcattct ggcttaacag agaatctgtg cctgcaagaa ctgtgtttgg agtaacaact   1080

gtcctaacaa tgacaactct aagcatcagt gctcggaatt ctctccccaa agtggcttat   1140

gcaactgcca tggactggtt tattgctgtt tgttatgcat ttgtgttctc tgccctaatt   1200

gaatttgcaa ctgttaatta cttcaccaaa agaggatgga cttgggatgg gaagagtgta   1260

gtaaatgaca agaaaaaaga aaaggcttcc gttatgatac agaacaacgc ttatgcagtg   1320

gctgttgcca attatgcccc gaatctttca aaagatccag ttctctccac catctccaag   1380

agtgcaacca cgccagaacc caacaagaag ccagaaaaca agccagctga agcaaagaaa   1440

actttcaaca gtgttagcaa aattgacaga atgtccagaa tagtttttcc agttttgttt   1500

ggtaccttta atttagttta ctgggctaca tatttaaaca gagaacctgt attaggggtc   1560

agtccttgaa ttgagaccca tgttatcttt gggatgtata gcaacattaa atttggtttg   1620

ttttgctatg tacagtctga ctaataactg ctaatttgtg atccaacatg tacagtatgt   1680

atatagtgac atagcttacc agtagacctt taatggagac atgcatttgc taactcatgg   1740

aactgcagac agaaagcact ccatgcgaaa acagccattg ccttttttaa agatttaccc   1800

taggacctga tttaaagtga atttcaagtg acctgattaa tttcctattc ttccaaatga   1860

gatgaaaatg gggatcctgt acaacccttt gtggaccctt ttggtttagc tcttaagtag   1920

gggtattttc tactgttgct taattatgat ggaagataac attgtcattc ctagatgaat   1980

cctttgaagt aacaaacatt gtatctgaca tcagctctgt tcatgagtgc tcagagtccc   2040

tgctaatgta attggaagct tggtacacat aagaaaaact agagatttga aatctagcta   2100

tgaattactc tatatagtat ctatagccat gtacatatta cagcatgaca agctcgaaat   2160

aattatgagt cagcccgaaa gatgttaat                                     2189


<210>  230
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  230

Met Lys Thr Lys Leu Asn Ile Tyr Asn Ile Glu Phe Leu Leu Phe Val 
1               5                   10                  15


Phe Leu Val Trp Asp Pro Ala Arg Leu Val Leu Ala Asn Ile Gln Glu 
            20                  25                  30


Asp Glu Ala Lys Asn Asn Ile Thr Ile Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Asp Ser 
    50                  55                  60


Ile Thr Glu Val Phe Thr Asn Ile Tyr Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80


Ser Asp Thr Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Lys 
                85                  90                  95


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Asn Ile Leu Arg 
            100                 105                 110


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140


Leu Leu Arg Ile Gln Asp Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160


Thr Val Gln Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175


Ala His Ser Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Thr Ser 
            180                 185                 190


Glu Val Thr Tyr Ile Trp Thr Tyr Asn Ala Ser Asp Ser Val Gln Val 
        195                 200                 205


Ala Pro Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Ser 
    210                 215                 220


Ile Gly Lys Glu Thr Ile Lys Ser Ser Thr Gly Glu Tyr Thr Val Met 
225                 230                 235                 240


Thr Ala His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335


Phe Thr Lys Arg Gly Trp Thr Trp Asp Gly Lys Ser Val Val Asn Asp 
            340                 345                 350


Lys Lys Lys Glu Lys Ala Ser Val Met Ile Gln Asn Asn Ala Tyr Ala 
        355                 360                 365


Val Ala Val Ala Asn Tyr Ala Pro Asn Leu Ser Lys Asp Pro Val Leu 
    370                 375                 380


Ser Thr Ile Ser Lys Ser Ala Thr Thr Pro Glu Pro Asn Lys Lys Pro 
385                 390                 395                 400


Glu Asn Lys Pro Ala Glu Ala Lys Lys Thr Phe Asn Ser Val Ser Lys 
                405                 410                 415


Ile Asp Arg Met Ser Arg Ile Val Phe Pro Val Leu Phe Gly Thr Phe 
            420                 425                 430


Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Val Leu Gly 
        435                 440                 445


Val Ser Pro 
    450


<210>  231
<211>  566
<212>  DNA
<213>  Homo sapiens

<400>  231
tccaggctgt aaaacggaaa ggttcggaat ttgcctctgc gccgtctttt tttgcctgtt     60

acctgtgacg tccttggaag cagaatctga aactttctga ggagagcatt tgagcttcag    120

atttctaaca gcctctttgc aacaaaatag accagtagct gaaggcaact gcaatccttc    180

atgatgtttc ccttggccag aaatgcacta agcagtctca agattcaaag cattctgcaa    240

agcatggcaa gacatagcca tgtaaaacac tcaccagatt ttcatgataa atatggtaat    300

gctgtgctag ccagtggaac tgctttctgt gttgctacat gggtgtttac agccactcag    360

attggaatag aatggaacct atcccctgtt ggcagagtta ccccaaaaga gtggaaacat    420

cagtaaccat cacagttgct gtaatgacag aattgtttaa aaaaccaact tgtcatgtaa    480

gcactctact gcttattaaa atatagcaca attgaaaaaa taaaatgtgt tttaaatctt    540

taaaaaaaaa aaaaaaaaaa aaaaaa                                         566


<210>  232
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  232

Met Met Phe Pro Leu Ala Arg Asn Ala Leu Ser Ser Leu Lys Ile Gln 
1               5                   10                  15


Ser Ile Leu Gln Ser Met Ala Arg His Ser His Val Lys His Ser Pro 
            20                  25                  30


Asp Phe His Asp Lys Tyr Gly Asn Ala Val Leu Ala Ser Gly Thr Ala 
        35                  40                  45


Phe Cys Val Ala Thr Trp Val Phe Thr Ala Thr Gln Ile Gly Ile Glu 
    50                  55                  60


Trp Asn Leu Ser Pro Val Gly Arg Val Thr Pro Lys Glu Trp Lys His 
65                  70                  75                  80


Gln 



<210>  233
<211>  1634
<212>  DNA
<213>  Homo sapiens

<400>  233
gggtggggaa gcttagagac cggtgaggga gcagagctgg ggcgcctgtg tacagggata     60

gagcccggcg gcagcagggc gcggcttccc tttcccgggg cctggggccg caatcaggtg    120

gagtcgagag gccggaggag gggcaggagg aaggggtgcg gtcgcgatcc ggacccggag    180

ccagcgcgga gcacctgcgc ccgcggctga caccttcgct cgcagtttgt tcgcagttta    240

ctcgcacacc agtttccccc accgcgcttt ggattagtgt gatctcagct caaggcaaag    300

gtgggatatc atggcatcta tctgggttgg acaccgagga acagtaagag attatccaga    360

ctttagccca tcagtggatg ctgaagctat tcagaaagca atcagaggaa ttggaactga    420

tgagaaaatg ctcatcagca ttctgactga gaggtcaaat gcacagcggc agctgattgt    480

taaggaatat caagcagcat atggaaagga gctgaaagat gacttgaagg gtgatctctc    540

tggccacttt gagcatctca tggtggccct agtgactcca ccagcagtct ttgatgcaaa    600

gcagctaaag aaatccatga agggcgcggg aacaaacgaa gatgccttga ttgaaatctt    660

aactaccagg acaagcaggc aaatgaagga tatctctcaa gcctattata cagtatacaa    720

gaagagtctt ggagatgaca ttagttccga aacatctggt gacttccgga aagctctgtt    780

gactttggca gatggcagaa gagatgaaag tctgaaagtg gatgagcatc tggccaaaca    840

agatgcccag attctctata aagctggtga gaacagatgg ggcacggatg aagacaaatt    900

cactgagatc ctgtgtttaa ggagctttcc tcaattaaaa ctaacatttg atgaatacag    960

aaatatcagc caaaaggaca ttgtggacag cataaaagga gaattatctg ggcattttga   1020

agacttactg ttggccatag ttaattgtgt gaggaacacg ccggcctttt tagccgaaag   1080

actgcatcga gccttgaagg gtattggaac tgatgagttt actctgaacc gaataatggt   1140

gtccagatca gaaattgacc ttttggacat tcgaacagag ttcaagaagc attatggcta   1200

ttccctatat tcagcaatta aatcggatac ttctggagac tatgaaatca cactcttaaa   1260

aatctgtggt ggagatgact gaaccaagaa gataatctcc aaaggtccac gatgggcttt   1320

cccaacagct ccaccttact tcttctcata ctatttaaga gaacaagcaa atataaacag   1380

caacttgtgt tcctaacagg aattttcatt gttctataac aacaacaaca aaagcgatta   1440

ttattttaga gcatctcatt tataatgtag cagctcataa atgaaattga aaatggtatt   1500

aaagatctgc aactactatc caacttatat ttctgctttc aaagttaaga atctttatag   1560

ttctactcca ttaaatataa agcaagataa taaaaattgt tgcttttgtt aaaagtaaaa   1620

aaaaaaaaaa aaaa                                                     1634


<210>  234
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  234

Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg Asp Tyr Pro 
1               5                   10                  15


Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg 
            20                  25                  30


Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu Thr Glu Arg 
        35                  40                  45


Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr 
    50                  55                  60


Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe 
65                  70                  75                  80


Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val Phe Asp Ala 
                85                  90                  95


Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Thr Asn Glu Asp Ala 
            100                 105                 110


Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln Met Lys Asp Ile 
        115                 120                 125


Ser Gln Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp Asp Ile 
    130                 135                 140


Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala Leu Leu Thr Leu Ala 
145                 150                 155                 160


Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His Leu Ala Lys 
                165                 170                 175


Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly Thr 
            180                 185                 190


Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu Arg Ser Phe Pro Gln 
        195                 200                 205


Leu Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys Asp Ile 
    210                 215                 220


Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu Asp Leu Leu 
225                 230                 235                 240


Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe Leu Ala Glu 
                245                 250                 255


Arg Leu His Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe Thr Leu 
            260                 265                 270


Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile Arg 
        275                 280                 285


Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys 
    290                 295                 300


Ser Asp Thr Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys Gly 
305                 310                 315                 320


Gly Asp Asp 



<210>  235
<211>  2681
<212>  DNA
<213>  Homo sapiens

<400>  235
cggggcccag gctgtgcgct tggggagcgc ggaatgtgag gcttggcggg ccgcagcacg     60

ctcggacggg ccaggggcgg cgacccctcg cggacgcccg gctgcgcgcc gggccgggga    120

cttgcccttg cacgctccct gcgccctcca gctcgccggc gggaccatga agaagttctc    180

tcggatgccc aagtcggagg gcggcagcgg cggcggagcg gcgggtggcg gggctggcgg    240

ggccggggcc ggggccggct gcggctccgg cggctcgtcc gtgggggtcc gggtgttcgc    300

ggtcggccgc caccaggtca ccctggaaga gtcgctggcc gaaggtggat tctccacagt    360

tttcctcgtg cgtactcacg gtggaatccg atgtgcattg aagcgaatgt atgtcaataa    420

catgccagac ctcaatgttt gtaaaaggga aattacaatt atgaaagagc tatctggtca    480

caaaaatatt gtgggctatt tggactgtgc tgttaattca attagtgata atgtatggga    540

agtccttatc ttaatggaat attgtcgagc tggacaggta gtgaatcaaa tgaataagaa    600

gctacagacg ggttttacag aaccagaagt gttacagata ttctgtgata cctgtgaagc    660

tgttgcaagg ttgcatcagt gtaagactcc aataattcac cgggatctga aggtagaaaa    720

tattttgttg aatgatggtg ggaactatgt actttgtgac tttggcagtg ccactaataa    780

atttcttaat cctcaaaaag atggagttaa tgtagtagaa gaagaaatta aaaagtatac    840

aactctgtca tacagagccc ctgaaatgat caacctttat ggagggaaac ccatcaccac    900

caaggctgat atctgggcac tgggatgtct actctataaa ctttgtttct tcactcttcc    960

ttttggtgag agtcaggttg ctatctgtga tggcaacttc accatcccag acaattctcg   1020

ttactcccgt aacatacatt gcttaataag gttcatgctt gaaccagatc cggaacatag   1080

acctgatata tttcaagtgt catattttgc atttaaattt gccaaaaagg attgtccagt   1140

ctccaacatc aataattctt ctattccttc agctcttcct gaaccgatga ctgctagtga   1200

agcagctgct aggaaaagcc aaataaaagc cagaataaca gataccattg gaccaacaga   1260

aacctcaatt gcaccaagac aaagaccaaa ggccaactct gctactactg ccactcccag   1320

tgtgctgacc attcaaagtt cagcaacacc tgttaaagtc cttgctcctg gtgaattcgg   1380

taaccataga ccaaaagggg cactaagacc tggaaatggc cctgaaattt tattgggtca   1440

gggacctcct cagcagccgc cacagcagca tagagtactc cagcaactac agcagggaga   1500

ttggagatta cagcaactcc atttacagca tcgtcatcct caccagcagc agcagcagca   1560

gcagcagcaa cagcaacagc agcagcagca acagcaacag cagcagcagc agcagcagca   1620

gcagcaccac caccaccacc accaccacct acttcaagat gcttatatgc agcagtatca   1680

acatgcaaca cagcagcaac agatgcttca acaacaattt ttaatgcatt cggtatatca   1740

accacaacct tctgcatcac agtatcctac aatgatgccg cagtatcagc aggctttctt   1800

tcaacagcag atgctagctc aacatcagcc gtctcaacaa caggcatcac ctgaatatct   1860

tacctcccct caagagttct caccagcctt agtttcctac acttcatcac ttccagctca   1920

ggttggaacc ataatggact cctcctatag tgccaatagg tcagttgctg ataaagaggc   1980

cattgcaaat ttcacaaatc agaagaacat cagcaatcca cctgatatgt cagggtggaa   2040

tccttttgga gaggataatt tctctaagtt aacagaagag gaactattgg acagagaatt   2100

tgaccttcta agatcaagta agggacactt gaaggcttat tttgcttcac agtaaaataa   2160

cagctctatt attattcagc aaggccaaag acttttgaga atgtgtatgg aaaattcttt   2220

ttgtgcattt gagggcaaaa ttcaggccat cttcttatac atatactatc aaattatgtt   2280

gtgtgcatta gaaatcagtt gcttgatagt agctattaaa cccaatattg ctgatagtat   2340

gctaatatcc taaaacttaa atattgcata tctatgaatg ttaaattcag aatatctcta   2400

aaacatggaa aattgatgtt tcaataaaaa gggagacatt ttattatttt gccttactaa   2460

tgattttgca gctctgtttt tctgcacact caatagaaaa tattgtgggt ctgagatgcc   2520

ctttgaaaat gcctgaaaga aaacatgggc tactacatta tgttaatgtt ttgtaatgtc   2580

cttttaatga gtggtgacat aaaagggctg ctttgttgtc ctgatatggc aaaaattaaa   2640

taaattcttt ttcactttaa atcagaaaaa aaaaaaaaaa a                       2681


<210>  236
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  236

Met Lys Lys Phe Ser Arg Met Pro Lys Ser Glu Gly Gly Ser Gly Gly 
1               5                   10                  15


Gly Ala Ala Gly Gly Gly Ala Gly Gly Ala Gly Ala Gly Ala Gly Cys 
            20                  25                  30


Gly Ser Gly Gly Ser Ser Val Gly Val Arg Val Phe Ala Val Gly Arg 
        35                  40                  45


His Gln Val Thr Leu Glu Glu Ser Leu Ala Glu Gly Gly Phe Ser Thr 
    50                  55                  60


Val Phe Leu Val Arg Thr His Gly Gly Ile Arg Cys Ala Leu Lys Arg 
65                  70                  75                  80


Met Tyr Val Asn Asn Met Pro Asp Leu Asn Val Cys Lys Arg Glu Ile 
                85                  90                  95


Thr Ile Met Lys Glu Leu Ser Gly His Lys Asn Ile Val Gly Tyr Leu 
            100                 105                 110


Asp Cys Ala Val Asn Ser Ile Ser Asp Asn Val Trp Glu Val Leu Ile 
        115                 120                 125


Leu Met Glu Tyr Cys Arg Ala Gly Gln Val Val Asn Gln Met Asn Lys 
    130                 135                 140


Lys Leu Gln Thr Gly Phe Thr Glu Pro Glu Val Leu Gln Ile Phe Cys 
145                 150                 155                 160


Asp Thr Cys Glu Ala Val Ala Arg Leu His Gln Cys Lys Thr Pro Ile 
                165                 170                 175


Ile His Arg Asp Leu Lys Val Glu Asn Ile Leu Leu Asn Asp Gly Gly 
            180                 185                 190


Asn Tyr Val Leu Cys Asp Phe Gly Ser Ala Thr Asn Lys Phe Leu Asn 
        195                 200                 205


Pro Gln Lys Asp Gly Val Asn Val Val Glu Glu Glu Ile Lys Lys Tyr 
    210                 215                 220


Thr Thr Leu Ser Tyr Arg Ala Pro Glu Met Ile Asn Leu Tyr Gly Gly 
225                 230                 235                 240


Lys Pro Ile Thr Thr Lys Ala Asp Ile Trp Ala Leu Gly Cys Leu Leu 
                245                 250                 255


Tyr Lys Leu Cys Phe Phe Thr Leu Pro Phe Gly Glu Ser Gln Val Ala 
            260                 265                 270


Ile Cys Asp Gly Asn Phe Thr Ile Pro Asp Asn Ser Arg Tyr Ser Arg 
        275                 280                 285


Asn Ile His Cys Leu Ile Arg Phe Met Leu Glu Pro Asp Pro Glu His 
    290                 295                 300


Arg Pro Asp Ile Phe Gln Val Ser Tyr Phe Ala Phe Lys Phe Ala Lys 
305                 310                 315                 320


Lys Asp Cys Pro Val Ser Asn Ile Asn Asn Ser Ser Ile Pro Ser Ala 
                325                 330                 335


Leu Pro Glu Pro Met Thr Ala Ser Glu Ala Ala Ala Arg Lys Ser Gln 
            340                 345                 350


Ile Lys Ala Arg Ile Thr Asp Thr Ile Gly Pro Thr Glu Thr Ser Ile 
        355                 360                 365


Ala Pro Arg Gln Arg Pro Lys Ala Asn Ser Ala Thr Thr Ala Thr Pro 
    370                 375                 380


Ser Val Leu Thr Ile Gln Ser Ser Ala Thr Pro Val Lys Val Leu Ala 
385                 390                 395                 400


Pro Gly Glu Phe Gly Asn His Arg Pro Lys Gly Ala Leu Arg Pro Gly 
                405                 410                 415


Asn Gly Pro Glu Ile Leu Leu Gly Gln Gly Pro Pro Gln Gln Pro Pro 
            420                 425                 430


Gln Gln His Arg Val Leu Gln Gln Leu Gln Gln Gly Asp Trp Arg Leu 
        435                 440                 445


Gln Gln Leu His Leu Gln His Arg His Pro His Gln Gln Gln Gln Gln 
    450                 455                 460


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
465                 470                 475                 480


Gln Gln Gln Gln Gln Gln His His His His His His His His Leu Leu 
                485                 490                 495


Gln Asp Ala Tyr Met Gln Gln Tyr Gln His Ala Thr Gln Gln Gln Gln 
            500                 505                 510


Met Leu Gln Gln Gln Phe Leu Met His Ser Val Tyr Gln Pro Gln Pro 
        515                 520                 525


Ser Ala Ser Gln Tyr Pro Thr Met Met Pro Gln Tyr Gln Gln Ala Phe 
    530                 535                 540


Phe Gln Gln Gln Met Leu Ala Gln His Gln Pro Ser Gln Gln Gln Ala 
545                 550                 555                 560


Ser Pro Glu Tyr Leu Thr Ser Pro Gln Glu Phe Ser Pro Ala Leu Val 
                565                 570                 575


Ser Tyr Thr Ser Ser Leu Pro Ala Gln Val Gly Thr Ile Met Asp Ser 
            580                 585                 590


Ser Tyr Ser Ala Asn Arg Ser Val Ala Asp Lys Glu Ala Ile Ala Asn 
        595                 600                 605


Phe Thr Asn Gln Lys Asn Ile Ser Asn Pro Pro Asp Met Ser Gly Trp 
    610                 615                 620


Asn Pro Phe Gly Glu Asp Asn Phe Ser Lys Leu Thr Glu Glu Glu Leu 
625                 630                 635                 640


Leu Asp Arg Glu Phe Asp Leu Leu Arg Ser Ser Lys Gly His Leu Lys 
                645                 650                 655


Ala Tyr Phe Ala Ser Gln 
            660


<210>  237
<211>  3859
<212>  DNA
<213>  Homo sapiens

<400>  237
cggggcccag gctgtgcgct tggggagcgc ggaatgtgag gcttggcggg ccgcagcacg     60

ctcggacggg ccaggggcgg cgacccctcg cggacgcccg gctgcgcgcc gggccgggga    120

cttgcccttg cacgctccct gcgccctcca gctcgccggc gggaccatga agaagttctc    180

tcggatgccc aagtcggagg gcggcagcgg cggcggagcg gcgggtggcg gggctggcgg    240

ggccggggcc ggggccggct gcggctccgg cggctcgtcc gtgggggtcc gggtgttcgc    300

ggtcggccgc caccaggtca ccctggaaga gtcgctggcc gaaggtggat tctccacagt    360

tttcctcgtg cgtactcacg gtggaatccg atgtgcattg aagcgaatgt atgtcaataa    420

catgccagac ctcaatgttt gtaaaaggga aattacaatt atgaaagagc tatctggtca    480

caaaaatatt gtgggctatt tggactgtgc tgttaattca attagtgata atgtatggga    540

agtccttatc ttaatggaat attgtcgagc tggacaggta gtgaatcaaa tgaataagaa    600

gctacagacg ggttttacag aaccagaagt gttacagata ttctgtgata cctgtgaagc    660

tgttgcaagg ttgcatcagt gtaagactcc aataattcac cgggatctga aggtagaaaa    720

tattttgttg aatgatggtg ggaactatgt actttgtgac tttggcagtg ccactaataa    780

atttcttaat cctcaaaaag atggagttaa tgtagtagaa gaagaaatta aaaagtatac    840

aactctgtca tacagagccc ctgaaatgat caacctttat ggagggaaac ccatcaccac    900

caaggctgat atctgggcac tgggatgtct actctataaa ctttgtttct tcactcttcc    960

ttttggtgag agtcaggttg ctatctgtga tggcaacttc accatcccag acaattctcg   1020

ttactcccgt aacatacatt gcttaataag gttcatgctt gaaccagatc cggaacatag   1080

acctgatata tttcaagtgt catattttgc atttaaattt gccaaaaagg attgtccagt   1140

ctccaacatc aataattctt ctattccttc agctcttcct gaaccgatga ctgctagtga   1200

agcagctgct aggaaaagcc aaataaaagc cagaataaca gataccattg gaccaacaga   1260

aacctcaatt gcaccaagac aaagaccaaa ggccaactct gctactactg ccactcccag   1320

tgtgctgacc attcaaagtt cagcaacacc tgttaaagtc cttgctcctg gtgaattcgg   1380

taaccataga ccaaaagggg cactaagacc tggaaatggc cctgaaattt tattgggtca   1440

gggacctcct cagcagccgc cacagcagca tagagtactc cagcaactac agcagggaga   1500

ttggagatta cagcaactcc atttacagca tcgtcatcct caccagcagc agcagcagca   1560

gcagcagcaa cagcaacagc agcagcagca acagcaacag cagcagcagc agcagcagca   1620

gcagcaccac caccaccacc accaccacct acttcaagat gcttatatgc agcagtatca   1680

acatgcaaca cagcagcaac agatgcttca acaacaattt ttaatgcatt cggtatatca   1740

accacaacct tctgcatcac agtatcctac aatgatgccg cagtatcagc aggctttctt   1800

tcaacagcag atgctagctc aacatcagcc gtctcaacaa caggcatcac ctgaatatct   1860

tacctcccct caagagttct caccagcctt agtttcctac acttcatcac ttccagctca   1920

ggttggaacc ataatggact cctcctatag tgccaatagg tcagttgctg ataaagaggc   1980

cattgcaaat ttcacaaatc agaagaacat cagcaatcca cctgatatgt cagggtggaa   2040

tccttttgga gaggataatt tctctaagtt aacagaagag gaactattgg acagagaatt   2100

tgaccttcta agatcaaata ggctcgagga gagagcatcc tcagataaga atgtagactc   2160

actttctgct ccacataacc atcctccaga agatcctttt ggttctgttc ctttcatttc   2220

tcattcaggt tctcctgaaa agaaagctga acattcatct ataaatcaag aaaatggcac   2280

tgcaaaccct atcaagaacg gtaaaacaag tccagcatct aaagatcagc ggactggaaa   2340

gaaaacctca gtacagggtc aagtgcaaaa ggggaatgat gaatctgaaa gtgattttga   2400

atcagatccc ccttctccta agagcagtga agaggaagag caagatgatg aagaagttct   2460

tcagggggaa caaggagatt ttaatgatga tgatactgaa ccagaaaatc tgggtcatag   2520

gcctctcctc atggattctg aagatgagga agaagaggag aaacatagct ctgattctga   2580

ttatgagcag gctaaagcaa agtacagtga catgagctct gtctacagag acagatctgg   2640

cagtggacca acccaagatc ttaatacaat actcctcacc tcagcccaat tatcctctga   2700

tgttgcagtg gagactccca aacaggagtt tgatgtattt ggcgctgtcc ccttctttgc   2760

agtgcgtgct caacagcccc agcaagaaaa gaatgaaaag aacctccctc aacacaggtt   2820

tcctgctgca ggactggagc aggaggaatt tgatgtattc acaaaggcgc cttttagcaa   2880

gaaggtgaat gtacaagaat gccatgcagt ggggcctgag gcacatacta tccctggtta   2940

tcccaaaagt gtagatgtat ttggctccac tccatttcag cccttcctca catcaacaag   3000

taaaagtgaa agcaatgagg acctttttgg gcttgtgccc tttgatgaaa taacggggag   3060

ccagcagcaa aaagtcaaac agcgcagctt acagaaactg tcctctcgcc aaaggcgcac   3120

aaagcaggat atgtccaaaa gtaatgggaa gcggcatcat ggcacgccaa ctagcacaaa   3180

gaagactttg aagcctacct atcgcactcc agagagggct cgcaggcaca aaaaagtggg   3240

ccgccgagac tctcaaagta gcaatgaatt tttaaccatc tcagactcca aggagaacat   3300

tagtgttgca ctgactgatg ggaaagatag ggggaatgtc ttacaacctg aggagagcct   3360

gttggacccc ttcggtgcca agcccttcca ttctccagac ctgtcatggc accctccaca   3420

tcagggcctg agcgacatcc gtgctgatca caatactgtc ctgccagggc ggccaagaca   3480

aaattcacta catgggtcat tccatagtgc agatgtattg aaaatggatg attttggtgc   3540

cgtgcccttt acagaacttg tggtgcaaag catcactcca catcagtccc aacagtccca   3600

accagtcgaa ttagacccat ttggtgctgc tccatttcct tctaaacagt agatacttct   3660

gatggattct cggcattaac tcctgtttca aaaaagtgtg aacagtttta tgaatttgaa   3720

agaaaatttg gtagctcttt atagcattca ttcttaaaga tcagtcagaa taggtgattt   3780

ctaaataaac caaatagaag aatgaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3840

aaaaaaaaaa aaaaaaaaa                                                3859


<210>  238
<211>  1161
<212>  PRT
<213>  Homo sapiens

<400>  238

Met Lys Lys Phe Ser Arg Met Pro Lys Ser Glu Gly Gly Ser Gly Gly 
1               5                   10                  15


Gly Ala Ala Gly Gly Gly Ala Gly Gly Ala Gly Ala Gly Ala Gly Cys 
            20                  25                  30


Gly Ser Gly Gly Ser Ser Val Gly Val Arg Val Phe Ala Val Gly Arg 
        35                  40                  45


His Gln Val Thr Leu Glu Glu Ser Leu Ala Glu Gly Gly Phe Ser Thr 
    50                  55                  60


Val Phe Leu Val Arg Thr His Gly Gly Ile Arg Cys Ala Leu Lys Arg 
65                  70                  75                  80


Met Tyr Val Asn Asn Met Pro Asp Leu Asn Val Cys Lys Arg Glu Ile 
                85                  90                  95


Thr Ile Met Lys Glu Leu Ser Gly His Lys Asn Ile Val Gly Tyr Leu 
            100                 105                 110


Asp Cys Ala Val Asn Ser Ile Ser Asp Asn Val Trp Glu Val Leu Ile 
        115                 120                 125


Leu Met Glu Tyr Cys Arg Ala Gly Gln Val Val Asn Gln Met Asn Lys 
    130                 135                 140


Lys Leu Gln Thr Gly Phe Thr Glu Pro Glu Val Leu Gln Ile Phe Cys 
145                 150                 155                 160


Asp Thr Cys Glu Ala Val Ala Arg Leu His Gln Cys Lys Thr Pro Ile 
                165                 170                 175


Ile His Arg Asp Leu Lys Val Glu Asn Ile Leu Leu Asn Asp Gly Gly 
            180                 185                 190


Asn Tyr Val Leu Cys Asp Phe Gly Ser Ala Thr Asn Lys Phe Leu Asn 
        195                 200                 205


Pro Gln Lys Asp Gly Val Asn Val Val Glu Glu Glu Ile Lys Lys Tyr 
    210                 215                 220


Thr Thr Leu Ser Tyr Arg Ala Pro Glu Met Ile Asn Leu Tyr Gly Gly 
225                 230                 235                 240


Lys Pro Ile Thr Thr Lys Ala Asp Ile Trp Ala Leu Gly Cys Leu Leu 
                245                 250                 255


Tyr Lys Leu Cys Phe Phe Thr Leu Pro Phe Gly Glu Ser Gln Val Ala 
            260                 265                 270


Ile Cys Asp Gly Asn Phe Thr Ile Pro Asp Asn Ser Arg Tyr Ser Arg 
        275                 280                 285


Asn Ile His Cys Leu Ile Arg Phe Met Leu Glu Pro Asp Pro Glu His 
    290                 295                 300


Arg Pro Asp Ile Phe Gln Val Ser Tyr Phe Ala Phe Lys Phe Ala Lys 
305                 310                 315                 320


Lys Asp Cys Pro Val Ser Asn Ile Asn Asn Ser Ser Ile Pro Ser Ala 
                325                 330                 335


Leu Pro Glu Pro Met Thr Ala Ser Glu Ala Ala Ala Arg Lys Ser Gln 
            340                 345                 350


Ile Lys Ala Arg Ile Thr Asp Thr Ile Gly Pro Thr Glu Thr Ser Ile 
        355                 360                 365


Ala Pro Arg Gln Arg Pro Lys Ala Asn Ser Ala Thr Thr Ala Thr Pro 
    370                 375                 380


Ser Val Leu Thr Ile Gln Ser Ser Ala Thr Pro Val Lys Val Leu Ala 
385                 390                 395                 400


Pro Gly Glu Phe Gly Asn His Arg Pro Lys Gly Ala Leu Arg Pro Gly 
                405                 410                 415


Asn Gly Pro Glu Ile Leu Leu Gly Gln Gly Pro Pro Gln Gln Pro Pro 
            420                 425                 430


Gln Gln His Arg Val Leu Gln Gln Leu Gln Gln Gly Asp Trp Arg Leu 
        435                 440                 445


Gln Gln Leu His Leu Gln His Arg His Pro His Gln Gln Gln Gln Gln 
    450                 455                 460


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
465                 470                 475                 480


Gln Gln Gln Gln Gln Gln His His His His His His His His Leu Leu 
                485                 490                 495


Gln Asp Ala Tyr Met Gln Gln Tyr Gln His Ala Thr Gln Gln Gln Gln 
            500                 505                 510


Met Leu Gln Gln Gln Phe Leu Met His Ser Val Tyr Gln Pro Gln Pro 
        515                 520                 525


Ser Ala Ser Gln Tyr Pro Thr Met Met Pro Gln Tyr Gln Gln Ala Phe 
    530                 535                 540


Phe Gln Gln Gln Met Leu Ala Gln His Gln Pro Ser Gln Gln Gln Ala 
545                 550                 555                 560


Ser Pro Glu Tyr Leu Thr Ser Pro Gln Glu Phe Ser Pro Ala Leu Val 
                565                 570                 575


Ser Tyr Thr Ser Ser Leu Pro Ala Gln Val Gly Thr Ile Met Asp Ser 
            580                 585                 590


Ser Tyr Ser Ala Asn Arg Ser Val Ala Asp Lys Glu Ala Ile Ala Asn 
        595                 600                 605


Phe Thr Asn Gln Lys Asn Ile Ser Asn Pro Pro Asp Met Ser Gly Trp 
    610                 615                 620


Asn Pro Phe Gly Glu Asp Asn Phe Ser Lys Leu Thr Glu Glu Glu Leu 
625                 630                 635                 640


Leu Asp Arg Glu Phe Asp Leu Leu Arg Ser Asn Arg Leu Glu Glu Arg 
                645                 650                 655


Ala Ser Ser Asp Lys Asn Val Asp Ser Leu Ser Ala Pro His Asn His 
            660                 665                 670


Pro Pro Glu Asp Pro Phe Gly Ser Val Pro Phe Ile Ser His Ser Gly 
        675                 680                 685


Ser Pro Glu Lys Lys Ala Glu His Ser Ser Ile Asn Gln Glu Asn Gly 
    690                 695                 700


Thr Ala Asn Pro Ile Lys Asn Gly Lys Thr Ser Pro Ala Ser Lys Asp 
705                 710                 715                 720


Gln Arg Thr Gly Lys Lys Thr Ser Val Gln Gly Gln Val Gln Lys Gly 
                725                 730                 735


Asn Asp Glu Ser Glu Ser Asp Phe Glu Ser Asp Pro Pro Ser Pro Lys 
            740                 745                 750


Ser Ser Glu Glu Glu Glu Gln Asp Asp Glu Glu Val Leu Gln Gly Glu 
        755                 760                 765


Gln Gly Asp Phe Asn Asp Asp Asp Thr Glu Pro Glu Asn Leu Gly His 
    770                 775                 780


Arg Pro Leu Leu Met Asp Ser Glu Asp Glu Glu Glu Glu Glu Lys His 
785                 790                 795                 800


Ser Ser Asp Ser Asp Tyr Glu Gln Ala Lys Ala Lys Tyr Ser Asp Met 
                805                 810                 815


Ser Ser Val Tyr Arg Asp Arg Ser Gly Ser Gly Pro Thr Gln Asp Leu 
            820                 825                 830


Asn Thr Ile Leu Leu Thr Ser Ala Gln Leu Ser Ser Asp Val Ala Val 
        835                 840                 845


Glu Thr Pro Lys Gln Glu Phe Asp Val Phe Gly Ala Val Pro Phe Phe 
    850                 855                 860


Ala Val Arg Ala Gln Gln Pro Gln Gln Glu Lys Asn Glu Lys Asn Leu 
865                 870                 875                 880


Pro Gln His Arg Phe Pro Ala Ala Gly Leu Glu Gln Glu Glu Phe Asp 
                885                 890                 895


Val Phe Thr Lys Ala Pro Phe Ser Lys Lys Val Asn Val Gln Glu Cys 
            900                 905                 910


His Ala Val Gly Pro Glu Ala His Thr Ile Pro Gly Tyr Pro Lys Ser 
        915                 920                 925


Val Asp Val Phe Gly Ser Thr Pro Phe Gln Pro Phe Leu Thr Ser Thr 
    930                 935                 940


Ser Lys Ser Glu Ser Asn Glu Asp Leu Phe Gly Leu Val Pro Phe Asp 
945                 950                 955                 960


Glu Ile Thr Gly Ser Gln Gln Gln Lys Val Lys Gln Arg Ser Leu Gln 
                965                 970                 975


Lys Leu Ser Ser Arg Gln Arg Arg Thr Lys Gln Asp Met Ser Lys Ser 
            980                 985                 990


Asn Gly Lys Arg His His Gly Thr Pro Thr Ser Thr Lys Lys Thr Leu 
        995                 1000                1005


Lys Pro Thr Tyr Arg Thr Pro Glu Arg Ala Arg Arg His Lys Lys Val 
    1010                1015                1020


Gly Arg Arg Asp Ser Gln Ser Ser Asn Glu Phe Leu Thr Ile Ser Asp 
1025                1030                1035                1040


Ser Lys Glu Asn Ile Ser Val Ala Leu Thr Asp Gly Lys Asp Arg Gly 
                1045                1050                1055


Asn Val Leu Gln Pro Glu Glu Ser Leu Leu Asp Pro Phe Gly Ala Lys 
            1060                1065                1070


Pro Phe His Ser Pro Asp Leu Ser Trp His Pro Pro His Gln Gly Leu 
        1075                1080                1085


Ser Asp Ile Arg Ala Asp His Asn Thr Val Leu Pro Gly Arg Pro Arg 
    1090                1095                1100


Gln Asn Ser Leu His Gly Ser Phe His Ser Ala Asp Val Leu Lys Met 
1105                1110                1115                1120


Asp Asp Phe Gly Ala Val Pro Phe Thr Glu Leu Val Val Gln Ser Ile 
                1125                1130                1135


Thr Pro His Gln Ser Gln Gln Ser Gln Pro Val Glu Leu Asp Pro Phe 
            1140                1145                1150


Gly Ala Ala Pro Phe Pro Ser Lys Gln 
        1155                1160


<210>  239
<211>  4445
<212>  DNA
<213>  Homo sapiens

<400>  239
gtcagcgctg cctgagctcg tcccctggat gtccgggtct ccccaggcgg ccacccgccg     60

gctcccatcg tgacctccag ccgcagcgcc tcccacgccg gccgccgcgc gaggggagcg    120

ctcgggcgcg ccgggtgtgg ttgggggaag gggttgtgcc gcgcgcgggc tgcgtgctgt    180

gcccactcaa aaggttccgg gcgcgcagga gggaagaggc agtgcccgcc actcccactg    240

agattgagag acgcggcaag gaggcagcct gtggaggaac tgggtaggat ttaggaacgc    300

accgtgcaca tgcttggtgg tcttgttaag tggaaactgc tgctttagag tttgtttgga    360

aggtccgggt gactcatccc aacatttaca tccttaattg ttaaagcgct gcctccgagc    420

gcacgcatcc tgagatcctg agcctttggt taagaccgag ctctattaag ctgaaaagat    480

aaaaactctc cagatgtctt ccagtaatgt cgaagttttt atcccagtgt cacaaggaaa    540

caccaatggc ttccccgcga cagcttccaa tgacctgaag gcatttactg aaggagctgt    600

gttaagtttt cataacatct gctatcgagt aaaactgaag agtggctttc taccttgtcg    660

aaaaccagtt gagaaagaaa tattatcgaa tatcaatggg atcatgaaac ctggtctcaa    720

cgccatcctg ggacccacag gtggaggcaa atcttcgtta ttagatgtct tagctgcaag    780

gaaagatcca agtggattat ctggagatgt tctgataaat ggagcaccgc gacctgccaa    840

tttcaaatgt aattcaggtt acgtggtaca agatgatgtt gtgatgggca ctctgacggt    900

gagagaaaac ttacagttct cagcagctct tcggcttgca acaactatga cgaatcatga    960

aaaaaacgaa cggattaaca gggtcattca agagttaggt ctggataaag tggcagactc   1020

caaggttgga actcagttta tccgtggtgt gtctggagga gaaagaaaaa ggactagtat   1080

aggaatggag cttatcactg atccttccat cttgttcttg gatgagccta caactggctt   1140

agactcaagc acagcaaatg ctgtcctttt gctcctgaaa aggatgtcta agcagggacg   1200

aacaatcatc ttctccattc atcagcctcg atattccatc ttcaagttgt ttgatagcct   1260

caccttattg gcctcaggaa gacttatgtt ccacgggcct gctcaggagg ccttgggata   1320

ctttgaatca gctggttatc actgtgaggc ctataataac cctgcagact tcttcttgga   1380

catcattaat ggagattcca ctgctgtggc attaaacaga gaagaagact ttaaagccac   1440

agagatcata gagccttcca agcaggataa gccactcata gaaaaattag cggagattta   1500

tgtcaactcc tccttctaca aagagacaaa agctgaatta catcaacttt ccgggggtga   1560

gaagaagaag aagatcacag tcttcaagga gatcagctac accacctcct tctgtcatca   1620

actcagatgg gtttccaagc gttcattcaa aaacttgctg ggtaatcccc aggcctctat   1680

agctcagatc attgtcacag tcgtactggg actggttata ggtgccattt actttgggct   1740

aaaaaatgat tctactggaa tccagaacag agctggggtt ctcttcttcc tgacgaccaa   1800

ccagtgtttc agcagtgttt cagccgtgga actctttgtg gtagagaaga agctcttcat   1860

acatgaatac atcagcggat actacagagt gtcatcttat ttccttggaa aactgttatc   1920

tgatttatta cccatgagga tgttaccaag tattatattt acctgtatag tgtacttcat   1980

gttaggattg aagccaaagg cagatgcctt cttcgttatg atgtttaccc ttatgatggt   2040

ggcttattca gccagttcca tggcactggc catagcagca ggtcagagtg tggtttctgt   2100

agcaacactt ctcatgacca tctgttttgt gtttatgatg attttttcag gtctgttggt   2160

caatctcaca accattgcat cttggctgtc atggcttcag tacttcagca ttccacgata   2220

tggatttacg gctttgcagc ataatgaatt tttgggacaa aacttctgcc caggactcaa   2280

tgcaacagga aacaatcctt gtaactatgc aacatgtact ggcgaagaat atttggtaaa   2340

gcagggcatc gatctctcac cctggggctt gtggaagaat cacgtggcct tggcttgtat   2400

gattgttatt ttcctcacaa ttgcctacct gaaattgtta tttcttaaaa aatattctta   2460

aatttcccct taattcagta tgatttatcc tcacataaaa aagaagcact ttgattgaag   2520

tattcaatca agtttttttg ttgttttctg ttcccttgcc atcacactgt tgcacagcag   2580

caattgtttt aaagagatac atttttagaa atcacaacaa actgaattaa acatgaaaga   2640

acccaagaca tcatgtatcg catattagtt aatctcctca gacagtaacc atggggaaga   2700

aatctggtct aatttattaa tctaaaaaag gagaattgaa ttctggaaac tcctgacaag   2760

ttattactgt ctctggcatt tgtttcctca tctttaaaat gaataggtag gttagtagcc   2820

cttcagtctt aatactttat gatgctatgg tttgccatta tttaataaat gacaaatgta   2880

ttaatgctat actggaaatg taaaattgaa aatatgttgg aaaaaagatt ctgtcttata   2940

gggtaaaaaa agccaccgtg atagaaaaaa aatctttttg ataagcacat taaagttaat   3000

agaacttact gatattcctg tctagtggta taatatctca ggaatcttgg ctgagggttt   3060

ggaactgtgg gtagagtaga gggccaggag tccagtaata gaattcttgc accatttctg   3120

gaacattcta gctctgggag gtcacgtaac cttcttgggg tagttcagtg gtttagtggt   3180

ttataatcca ggtgtgcgtc agaatcatct gaggaacttt gctaaaatac aaaaatctgg   3240

cctaagtagc tccagatcta ccttcataaa ggaatctgac cactcctgga tttggtaatt   3300

tccaagttct gaaaatttta cttaggattt aataactatt aacatctgtc cctacatagg   3360

ttttctttcc tacttatata ccttatgttc tcttcattct aaccttcatc agtaataggg   3420

aaatgtttta attttatttt tttagttgaa gggtaatgta ccaaaaaata tagttcagtg   3480

aattaaaatg aacacacatg tgcaaccatc aattcaggtc aagaaataga agattgtagc   3540

acacaaaagc ctactcagcc attctcccag tcactacttc cttccttacc cctgggttat   3600

ttttgaaatg acacttgatg tatttccctc tgttgctgtt atgagaacat tgctacagcc   3660

aagtgttgtg tttctgtgtg cataggttga tacttaatta tctccccact ttttaataaa   3720

cttttaattt ggaaataatt ttagattgac agaaaagttg caaagatagt gaggaaagtt   3780

cctgtctact ctttgctcag cttcccttaa tgttaacatt ttatatagca agatgcattt   3840

gtcaaagcta acaagttaac attggtacaa tcactgttaa ttaaactgca cacaatattc   3900

agatttcacc acttttccac taatattctt tcattgttct aggattcaat tcaggagacc   3960

acatttcatc tagccctctt ttttaaaagt aaatactttt cagcacttac aggagttaac   4020

tgagctgggg catcatggtg tatagacgcc ctgacactgg tcatcttgga attcatttag   4080

tttgtcagtg ggtgccctga cattctgtca caacatcaat ttgggaacat ggcattatat   4140

ttttatcttt gaactttttt ctttttggat gacatttgat taatgcgtca tcttggaaca   4200

cattatcttt tttcttggtt atgtgatcag gaagattaat cagtttttcc tgttcttggt   4260

ataattcctg cttttcacat acctgtccct tacagttctc tatatatacc cttcccttat   4320

tacacagaga gaaatatcta tctatacttt ttacacaaaa tatacttcaa aagaaacaaa   4380

acagccacaa ttattaactt tttaaataaa tgagaattta attatatcct aaaaaaaaaa   4440

aaaaa                                                               4445


<210>  240
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  240

Met Ser Ser Ser Asn Val Glu Val Phe Ile Pro Val Ser Gln Gly Asn 
1               5                   10                  15


Thr Asn Gly Phe Pro Ala Thr Ala Ser Asn Asp Leu Lys Ala Phe Thr 
            20                  25                  30


Glu Gly Ala Val Leu Ser Phe His Asn Ile Cys Tyr Arg Val Lys Leu 
        35                  40                  45


Lys Ser Gly Phe Leu Pro Cys Arg Lys Pro Val Glu Lys Glu Ile Leu 
    50                  55                  60


Ser Asn Ile Asn Gly Ile Met Lys Pro Gly Leu Asn Ala Ile Leu Gly 
65                  70                  75                  80


Pro Thr Gly Gly Gly Lys Ser Ser Leu Leu Asp Val Leu Ala Ala Arg 
                85                  90                  95


Lys Asp Pro Ser Gly Leu Ser Gly Asp Val Leu Ile Asn Gly Ala Pro 
            100                 105                 110


Arg Pro Ala Asn Phe Lys Cys Asn Ser Gly Tyr Val Val Gln Asp Asp 
        115                 120                 125


Val Val Met Gly Thr Leu Thr Val Arg Glu Asn Leu Gln Phe Ser Ala 
    130                 135                 140


Ala Leu Arg Leu Ala Thr Thr Met Thr Asn His Glu Lys Asn Glu Arg 
145                 150                 155                 160


Ile Asn Arg Val Ile Gln Glu Leu Gly Leu Asp Lys Val Ala Asp Ser 
                165                 170                 175


Lys Val Gly Thr Gln Phe Ile Arg Gly Val Ser Gly Gly Glu Arg Lys 
            180                 185                 190


Arg Thr Ser Ile Gly Met Glu Leu Ile Thr Asp Pro Ser Ile Leu Phe 
        195                 200                 205


Leu Asp Glu Pro Thr Thr Gly Leu Asp Ser Ser Thr Ala Asn Ala Val 
    210                 215                 220


Leu Leu Leu Leu Lys Arg Met Ser Lys Gln Gly Arg Thr Ile Ile Phe 
225                 230                 235                 240


Ser Ile His Gln Pro Arg Tyr Ser Ile Phe Lys Leu Phe Asp Ser Leu 
                245                 250                 255


Thr Leu Leu Ala Ser Gly Arg Leu Met Phe His Gly Pro Ala Gln Glu 
            260                 265                 270


Ala Leu Gly Tyr Phe Glu Ser Ala Gly Tyr His Cys Glu Ala Tyr Asn 
        275                 280                 285


Asn Pro Ala Asp Phe Phe Leu Asp Ile Ile Asn Gly Asp Ser Thr Ala 
    290                 295                 300


Val Ala Leu Asn Arg Glu Glu Asp Phe Lys Ala Thr Glu Ile Ile Glu 
305                 310                 315                 320


Pro Ser Lys Gln Asp Lys Pro Leu Ile Glu Lys Leu Ala Glu Ile Tyr 
                325                 330                 335


Val Asn Ser Ser Phe Tyr Lys Glu Thr Lys Ala Glu Leu His Gln Leu 
            340                 345                 350


Ser Gly Gly Glu Lys Lys Lys Lys Ile Thr Val Phe Lys Glu Ile Ser 
        355                 360                 365


Tyr Thr Thr Ser Phe Cys His Gln Leu Arg Trp Val Ser Lys Arg Ser 
    370                 375                 380


Phe Lys Asn Leu Leu Gly Asn Pro Gln Ala Ser Ile Ala Gln Ile Ile 
385                 390                 395                 400


Val Thr Val Val Leu Gly Leu Val Ile Gly Ala Ile Tyr Phe Gly Leu 
                405                 410                 415


Lys Asn Asp Ser Thr Gly Ile Gln Asn Arg Ala Gly Val Leu Phe Phe 
            420                 425                 430


Leu Thr Thr Asn Gln Cys Phe Ser Ser Val Ser Ala Val Glu Leu Phe 
        435                 440                 445


Val Val Glu Lys Lys Leu Phe Ile His Glu Tyr Ile Ser Gly Tyr Tyr 
    450                 455                 460


Arg Val Ser Ser Tyr Phe Leu Gly Lys Leu Leu Ser Asp Leu Leu Pro 
465                 470                 475                 480


Met Arg Met Leu Pro Ser Ile Ile Phe Thr Cys Ile Val Tyr Phe Met 
                485                 490                 495


Leu Gly Leu Lys Pro Lys Ala Asp Ala Phe Phe Val Met Met Phe Thr 
            500                 505                 510


Leu Met Met Val Ala Tyr Ser Ala Ser Ser Met Ala Leu Ala Ile Ala 
        515                 520                 525


Ala Gly Gln Ser Val Val Ser Val Ala Thr Leu Leu Met Thr Ile Cys 
    530                 535                 540


Phe Val Phe Met Met Ile Phe Ser Gly Leu Leu Val Asn Leu Thr Thr 
545                 550                 555                 560


Ile Ala Ser Trp Leu Ser Trp Leu Gln Tyr Phe Ser Ile Pro Arg Tyr 
                565                 570                 575


Gly Phe Thr Ala Leu Gln His Asn Glu Phe Leu Gly Gln Asn Phe Cys 
            580                 585                 590


Pro Gly Leu Asn Ala Thr Gly Asn Asn Pro Cys Asn Tyr Ala Thr Cys 
        595                 600                 605


Thr Gly Glu Glu Tyr Leu Val Lys Gln Gly Ile Asp Leu Ser Pro Trp 
    610                 615                 620


Gly Leu Trp Lys Asn His Val Ala Leu Ala Cys Met Ile Val Ile Phe 
625                 630                 635                 640


Leu Thr Ile Ala Tyr Leu Lys Leu Leu Phe Leu Lys Lys Tyr Ser 
                645                 650                 655


<210>  241
<211>  2103
<212>  DNA
<213>  Homo sapiens

<400>  241
tctccatctg gtcaactgcg ggagaaaaat tttcgagaat ttccagcagg caaggcagtg     60

gccgctttga ctgcttgctt cggagatccg agacgacgga gaaggcactc ttatttaccg    120

accaagaaag ctcctccccc gtcctccgtt agctaattaa aacatttttc agggacgtag    180

ccatccagag acattccatt attgttccat tgacctttcc ctcatcactg agtcctttgg    240

agctgagtta tgtcaacagc tgccttaatt actttggtca gaagtggtgg gaaccaggtg    300

agaaggagag tgctgctaag ctcccgcctg ctgcaggacg acaggcgggt gacacccacg    360

tgccacagct ccacttcaga gcctaggtgt tctcggtttg acccagatgg tagtgggagt    420

ccagctacct gggacaattt tgggatctgg gataaccgca ttgatgagcc aattctgctg    480

ccacccagca ttaagtatgg caagccaatt cccaaaatca gcttggaaaa ggtggggtgc    540

gcctcacaga ttggcaaacg gaaagagaat gaagatcggt ttgacttcgc tcagctgaca    600

gatgaggtcc tgtactttgc agtgtatgat ggacacggtg gacctgcagc agctgatttc    660

tgtcataccc acatggagaa atgtattatg gatttgcttc ctaaggagaa gaacttggaa    720

actctgttga ccttggcttt tctagaaata gataaagcct tttcgagtca tgcccgcctg    780

tctgctgatg caactcttct gacctctggg actactgcaa cagtagccct attgcgagat    840

ggtattgaac tggttgtagc cagtgttggg gacagccggg ctattttgtg tagaaaagga    900

aaacccatga agctgaccat tgaccatact ccagaaagaa aagatgaaaa agaaaggatc    960

aagaaatgtg gtggttttgt agcttggaat agtttggggc agcctcacgt aaatggcagg   1020

cttgcaatga caagaagtat tggagatttg gaccttaaga ccagtggtgt catagcagaa   1080

cctgaaacta agaggattaa gttacatcat gctgatgaca gcttcctggt cctcaccaca   1140

gatggaatta acttcatggt gaatagtcaa gagatttgtg actttgtcaa tcagtgccat   1200

gatcccaacg aagcagccca tgcggtgact gaacaggcaa tacagtacgg tactgaggat   1260

aacagtactg cagtagtagt gccttttggt gcctggggaa aatataagaa ctctgaaatc   1320

aacttctcat tcagcagaag ctttgcctcc agtggacgat gggcctgatt accagctggg   1380

acttagagtt tctgtgcaac agtttttcac tgagcatgtc aagaaactga taagatcaaa   1440

aaggtctcct aactcactag atcagcgcac aagtcagtgt aaaccactta gatagtagtt   1500

ttttcataaa tgctcatcat atttatgttc cgctgtacat gttcagtata aatatatgtg   1560

tagtgaagct actgtgagtc tttaaatgga aagagcaaat gagaagtggt ttggatacac   1620

ttgatgagag atgagagtgt cacattaata atttttaaga ctcttaggca gctatgggtt   1680

tcttcttaat catttttgtt ctttattcat ttgaacacgt ttttgaagtt cttcaaaact   1740

agtcagtttg aattttgaca gctattcaat atgtgatctc caagtttaaa aaaatttttt   1800

tccagacttc cctaatccta aaatgcgagt ttttattttt aataactgta ccaaggaata   1860

agtatgaaaa cagttctctg ttaccatatt ttgtattctg gaccacttac tggtgaaagc   1920

aaccatgcaa aagaaattaa tttggccagg cacagtggct catgcctgta atcccagcac   1980

tttgggaggc caaggtgggt agatcatctg aggtcaggaa ttcaagacca gcctggccaa   2040

catggtgaaa ccctgtctct agtaaaaatc caaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2100

aaa                                                                 2103


<210>  242
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  242

Met Ser Thr Ala Ala Leu Ile Thr Leu Val Arg Ser Gly Gly Asn Gln 
1               5                   10                  15


Val Arg Arg Arg Val Leu Leu Ser Ser Arg Leu Leu Gln Asp Asp Arg 
            20                  25                  30


Arg Val Thr Pro Thr Cys His Ser Ser Thr Ser Glu Pro Arg Cys Ser 
        35                  40                  45


Arg Phe Asp Pro Asp Gly Ser Gly Ser Pro Ala Thr Trp Asp Asn Phe 
    50                  55                  60


Gly Ile Trp Asp Asn Arg Ile Asp Glu Pro Ile Leu Leu Pro Pro Ser 
65                  70                  75                  80


Ile Lys Tyr Gly Lys Pro Ile Pro Lys Ile Ser Leu Glu Lys Val Gly 
                85                  90                  95


Cys Ala Ser Gln Ile Gly Lys Arg Lys Glu Asn Glu Asp Arg Phe Asp 
            100                 105                 110


Phe Ala Gln Leu Thr Asp Glu Val Leu Tyr Phe Ala Val Tyr Asp Gly 
        115                 120                 125


His Gly Gly Pro Ala Ala Ala Asp Phe Cys His Thr His Met Glu Lys 
    130                 135                 140


Cys Ile Met Asp Leu Leu Pro Lys Glu Lys Asn Leu Glu Thr Leu Leu 
145                 150                 155                 160


Thr Leu Ala Phe Leu Glu Ile Asp Lys Ala Phe Ser Ser His Ala Arg 
                165                 170                 175


Leu Ser Ala Asp Ala Thr Leu Leu Thr Ser Gly Thr Thr Ala Thr Val 
            180                 185                 190


Ala Leu Leu Arg Asp Gly Ile Glu Leu Val Val Ala Ser Val Gly Asp 
        195                 200                 205


Ser Arg Ala Ile Leu Cys Arg Lys Gly Lys Pro Met Lys Leu Thr Ile 
    210                 215                 220


Asp His Thr Pro Glu Arg Lys Asp Glu Lys Glu Arg Ile Lys Lys Cys 
225                 230                 235                 240


Gly Gly Phe Val Ala Trp Asn Ser Leu Gly Gln Pro His Val Asn Gly 
                245                 250                 255


Arg Leu Ala Met Thr Arg Ser Ile Gly Asp Leu Asp Leu Lys Thr Ser 
            260                 265                 270


Gly Val Ile Ala Glu Pro Glu Thr Lys Arg Ile Lys Leu His His Ala 
        275                 280                 285


Asp Asp Ser Phe Leu Val Leu Thr Thr Asp Gly Ile Asn Phe Met Val 
    290                 295                 300


Asn Ser Gln Glu Ile Cys Asp Phe Val Asn Gln Cys His Asp Pro Asn 
305                 310                 315                 320


Glu Ala Ala His Ala Val Thr Glu Gln Ala Ile Gln Tyr Gly Thr Glu 
                325                 330                 335


Asp Asn Ser Thr Ala Val Val Val Pro Phe Gly Ala Trp Gly Lys Tyr 
            340                 345                 350


Lys Asn Ser Glu Ile Asn Phe Ser Phe Ser Arg Ser Phe Ala Ser Ser 
        355                 360                 365


Gly Arg Trp Ala 
    370


<210>  243
<211>  3045
<212>  DNA
<213>  Homo sapiens

<400>  243
actaagaccg caaggcattc atttcctcct acggtggatg cggacgccgg gaggaggaga     60

gccccagaga gaggagctgg gagcggaggc gcaggcaatg ctcagccctg gatgtagctg    120

agaggctggg agaagagacg accgctggag accgagcggc gtggggaaga cctagggggg    180

tgggtggggg aagcagacag gagaacactc gaaatcaagc gctttacaga ttattttatt    240

ttgtatagag aacacgtagc gactccgaag atcagcccca atgaacatgt cagtgttgac    300

tttacaagaa tatgaattcg aaaagcagtt caacgagaat gaagccatcc aatggatgca    360

ggaaaactgg aagaaatctt tcctgttttc tgctctgtat gctgccttta tattcggtgg    420

tcggcaccta atgaataaac gagcaaagtt tgaactgagg aagccattag tgctctggtc    480

tctgaccctt gcagtcttca gtatattcgg tgctcttcga actggtgctt atatggtgta    540

cattttgatg accaaaggcc tgaagcagtc agtttgtgac cagggttttt acaatggacc    600

tgtcagcaaa ttctgggctt atgcatttgt gctaagcaaa gcacccgaac taggagatac    660

aatattcatt attctgagga agcagaagct gatcttcctg cactggtatc accacatcac    720

tgtgctcctg tactcttggt actcctacaa agacatggtt gccgggggag gttggttcat    780

gactatgaac tatggcgtgc acgccgtgat gtactcttac tatgccttgc gggcggcagg    840

tttccgagtc tcccggaagt ttgccatgtt catcaccttg tcccagatca ctcagatgct    900

gatgggctgt gtggttaact acctggtctt ctgctggatg cagcatgacc agtgtcactc    960

tcactttcag aacatcttct ggtcctcact catgtacctc agctaccttg tgctcttctg   1020

ccatttcttc tttgaggcct acatcggcaa aatgaggaaa acaacgaaag ctgaatagtg   1080

ttggaactga ggaggaagcc atagctcagg gtcatcaaga aaaataatag acaaaagaaa   1140

atggcacaag gaatcacacg tggtgcagct aaaacaaaac aaaacatgag caaacacaaa   1200

acccaaggca gcttagggat aattaggttg atttaaccca gtaagtttat gatcctttta   1260

gggtgaggac tcactgagtg cacctccatc tccaagcact gctgctggaa gaccccattc   1320

cctctttatc tatcaactct aggacaaggg agaacaaaag caagccagaa gcagaggaga   1380

ctaatcaaag gcaaacaaag gctattaaca cataggaaaa tatgtattta ctaagtgtca   1440

catttctcta agatgaaaga tttttactct agaaactgtg cgagcacaac acacacaatc   1500

ctttctaact ttatggacac taaactggag ccaatagaaa agacaaaaat gaaagagaca   1560

cagggtgtat atctagaacg ataatgcttt tgcagaaact aaagcctttt taagaaatgc   1620

cagctgctgt agaccccatg agaaaagatg tcttaatcat ccttatgaaa acagatgtaa   1680

acaactatat ttcaactaac ttcatcttca ctgcatagcc tcaggctagt gagtttgcca   1740

aaaccaaagg gggtgaatac ttccccaaga ttcttcctgg gaggatggaa acagtgcagc   1800

ccaggtccca tgggggcagc tccatcccag agcatttctg atagttgaac tgtaatttct   1860

actcttaagt gagatatgaa gtattatcct tttgttcagt tgccccgggc ttttgaacag   1920

aagagtaaat acagaattga aaaagataaa cactcaacca aacaatgtga aaacgggttc   1980

tgtagtattt gtaaaaaggc ccggcccagg accactgtga gctggaaaag ggagaaaggc   2040

agtgggaaaa gaggtgagcc gaagatcaat tcgacagaca gacggtgtgt atgcccctcc   2100

ctgtttgact tcacacacac tcataacttt ccaaatgaaa ccccacagta tagcgcatat   2160

tttcgatatt tttgtgaatt ccaaaaggaa atcacagggc tgttcgaaat attgggggaa   2220

cactgtgttt ctgcatcatc tgcatttgct ccccaagcaa tgtagaggtg tttaaagggc   2280

cctctgctgg ctgagtggca atactacaac aaacttcaag gcaagtttgg ctgaaaacag   2340

ttgacaacaa agggccccca tacacttatc cctcaaattt taagtgatat gaaatacttg   2400

tcatgtcttt ggccaaatca gaagatattc atcctgcttc aagtcagctt cagaaatgtt   2460

ttaaaaggga ctttagctct ggaactcaaa atcaatttat taagagccat attctttaaa   2520

aaaaaaagct ggataatatt atctgtaata tttcagtcct ttacaagcca aatacatgtg   2580

tcaatgtttc tagtatttca aagaagcaat tatgtaaagt tgttcaatgt gacataatag   2640

tattataatt ggttaagtag cttaatgatt aggcaaacta gatgaaaaga ttaggggctt   2700

ccacactgca tagatcacac gcacatagcc acgcatacac acacagacac acagatgtgg   2760

ggtacactga atttcaaagc ccaaatgaat agaaacacat tttctggcta gcagaaaaaa   2820

acaaaacaaa actgttgttt ctctttcttg ctttgagagt gtacagtaaa agggattttt   2880

tcgaattatt tttatattat tttagcttta attgtgctgt cgttcatgaa acagagctgc   2940

tctgcttttc tgtcagagat ggcaagggct ttttcagcat ctcgtttatg tgtggaattt   3000

aaaaagaata aagttttatt ccattctgaa aaaaaaaaaa aaaaa                   3045


<210>  244
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  244

Met Asn Met Ser Val Leu Thr Leu Gln Glu Tyr Glu Phe Glu Lys Gln 
1               5                   10                  15


Phe Asn Glu Asn Glu Ala Ile Gln Trp Met Gln Glu Asn Trp Lys Lys 
            20                  25                  30


Ser Phe Leu Phe Ser Ala Leu Tyr Ala Ala Phe Ile Phe Gly Gly Arg 
        35                  40                  45


His Leu Met Asn Lys Arg Ala Lys Phe Glu Leu Arg Lys Pro Leu Val 
    50                  55                  60


Leu Trp Ser Leu Thr Leu Ala Val Phe Ser Ile Phe Gly Ala Leu Arg 
65                  70                  75                  80


Thr Gly Ala Tyr Met Val Tyr Ile Leu Met Thr Lys Gly Leu Lys Gln 
                85                  90                  95


Ser Val Cys Asp Gln Gly Phe Tyr Asn Gly Pro Val Ser Lys Phe Trp 
            100                 105                 110


Ala Tyr Ala Phe Val Leu Ser Lys Ala Pro Glu Leu Gly Asp Thr Ile 
        115                 120                 125


Phe Ile Ile Leu Arg Lys Gln Lys Leu Ile Phe Leu His Trp Tyr His 
    130                 135                 140


His Ile Thr Val Leu Leu Tyr Ser Trp Tyr Ser Tyr Lys Asp Met Val 
145                 150                 155                 160


Ala Gly Gly Gly Trp Phe Met Thr Met Asn Tyr Gly Val His Ala Val 
                165                 170                 175


Met Tyr Ser Tyr Tyr Ala Leu Arg Ala Ala Gly Phe Arg Val Ser Arg 
            180                 185                 190


Lys Phe Ala Met Phe Ile Thr Leu Ser Gln Ile Thr Gln Met Leu Met 
        195                 200                 205


Gly Cys Val Val Asn Tyr Leu Val Phe Cys Trp Met Gln His Asp Gln 
    210                 215                 220


Cys His Ser His Phe Gln Asn Ile Phe Trp Ser Ser Leu Met Tyr Leu 
225                 230                 235                 240


Ser Tyr Leu Val Leu Phe Cys His Phe Phe Phe Glu Ala Tyr Ile Gly 
                245                 250                 255


Lys Met Arg Lys Thr Thr Lys Ala Glu 
            260                 265


<210>  245
<211>  300
<212>  DNA
<213>  Homo sapiens

<400>  245
atgctgcagc cgctcaaaga gcagcagtgc gtcatccctg gtgtatctga agacagcaac     60

aatcacaacc tgatgttgga ggctaccaag tggtccacca tccaggggct ggtggaattc    120

ctgcagctct gcaagcaagt ggccaagata ctgtctgcct tgaagtatcc caccatcagc    180

acagtgaaac tgctgtttca catgctgcta aataccacgt tcaacaacaa ggagactgac    240

tccaaggaga tccccatggc caagagggtg attgccaagg agctctacaa gacctgctag    300


<210>  246
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  246

Met Leu Gln Pro Leu Lys Glu Gln Gln Cys Val Ile Pro Gly Val Ser 
1               5                   10                  15


Glu Asp Ser Asn Asn His Asn Leu Met Leu Glu Ala Thr Lys Trp Ser 
            20                  25                  30


Thr Ile Gln Gly Leu Val Glu Phe Leu Gln Leu Cys Lys Gln Val Ala 
        35                  40                  45


Lys Ile Leu Ser Ala Leu Lys Tyr Pro Thr Ile Ser Thr Val Lys Leu 
    50                  55                  60


Leu Phe His Met Leu Leu Asn Thr Thr Phe Asn Asn Lys Glu Thr Asp 
65                  70                  75                  80


Ser Lys Glu Ile Pro Met Ala Lys Arg Val Ile Ala Lys Glu Leu Tyr 
                85                  90                  95


Lys Thr Cys 



<210>  247
<211>  378
<212>  DNA
<213>  Homo sapiens

<400>  247
atgggcatgt ttccaaatgt caccatcttc ctggacccac gctacaagag gctgcccttc     60

ctgcttgtct tcgagaggca gcagatggag aactctgtgg tcaggggcca aggcctcctg    120

gacaacgtca aagacggcag ctaccggctg gccaatgcaa gatctaccct ttgccggaaa    180

aacgtccccc aaatggtcaa caccaagagg aaccggctgg cccctaacaa gcaggtcttt    240

ctgtacctga acgagcttaa ccaggcagag gcggaggcag agcccgaggc ccaggacaaa    300

aagcagtggg gcttggatag agagcaggtg ttcccttggg aaacggtgtc agccaagctt    360

ctttggcatc tgggatag                                                  378


<210>  248
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  248

Met Gly Met Phe Pro Asn Val Thr Ile Phe Leu Asp Pro Arg Tyr Lys 
1               5                   10                  15


Arg Leu Pro Phe Leu Leu Val Phe Glu Arg Gln Gln Met Glu Asn Ser 
            20                  25                  30


Val Val Arg Gly Gln Gly Leu Leu Asp Asn Val Lys Asp Gly Ser Tyr 
        35                  40                  45


Arg Leu Ala Asn Ala Arg Ser Thr Leu Cys Arg Lys Asn Val Pro Gln 
    50                  55                  60


Met Val Asn Thr Lys Arg Asn Arg Leu Ala Pro Asn Lys Gln Val Phe 
65                  70                  75                  80


Leu Tyr Leu Asn Glu Leu Asn Gln Ala Glu Ala Glu Ala Glu Pro Glu 
                85                  90                  95


Ala Gln Asp Lys Lys Gln Trp Gly Leu Asp Arg Glu Gln Val Phe Pro 
            100                 105                 110


Trp Glu Thr Val Ser Ala Lys Leu Leu Trp His Leu Gly 
        115                 120                 125


<210>  249
<211>  5869
<212>  DNA
<213>  Homo sapiens

<400>  249
ccccctccgg gctttcgccc gccctctctc cctccctttt ttgcccgccc tggccctgcc     60

cctgcccctg ccccctcctc tcagcccctc cgcgcccggg gtgtcattgg gcccgggaga    120

cgggagccaa cttcaggctg ctcagaggaa gcccgtgcag tcagtcacct gggtgcaaga    180

gcgttgctgc ctcgggctct cccgctgcag ggagagcggc actcgctggc ctggatgtgg    240

ttggatttag gggggctccg cagcaggggt ttcgtggcgg tggcaagcgc tgcaacaggt    300

agacggcgag agacggaccc cggccgaggc agcgatggag accaaaggct accacagtct    360

ccctgaaggt ctagatatgg aaagacggtg gggtcaagtt tctcaggctg tggagcgttc    420

ttccctggga cctacagaga ggaccgatga gaataactac atggagattg tcaacgtaag    480

ctgtgtttcc ggtgctattc caaacaacag tactcaagga agcagcaaag aaaaacaaga    540

actactccct tgccttcagc aagacaataa tcggcctggg attttaacat ctgatattaa    600

aactgagctg gaatctaagg aactttcagc aactgtagct gagtccatgg gtttatatat    660

ggattctgta agagatgctg actattccta tgagcagcag aaccaacaag gaagcatgag    720

tccagctaag atttatcaga atgttgaaca gctggtgaaa ttttacaaag gaaatggcca    780

tcgtccttcc actctaagtt gtgtgaacac gcccttgaga tcatttatgt ctgactctgg    840

gagctccgtg aatggtggcg tcatgcgcgc cgttgttaaa agccctatca tgtgtcatga    900

gaaaagcccg tctgtttgca gccctctgaa catgacatct tcggtttgca gccctgctgg    960

aatcaactct gtgtcctcca ccacagccag ctttggcagt tttccagtgc acagcccaat   1020

cacccaggga actcctctga catgctcccc taatgttgaa aatcgaggct ccaggtcgca   1080

cagccctgca catgctagca atgtgggctc tcctctctca agtccgttaa gtagcatgaa   1140

atcctcaatt tccagccctc caagtcactg cagtgtaaaa tctccagtct ccagtcccaa   1200

taatgtcact ctgagatcct ctgtgtctag ccctgcaaat attaacaact caaggtgctc   1260

tgtttccagc ccttcgaaca ctaataacag atccacgctt tccagtccgg cagccagtac   1320

tgtgggatct atctgtagcc ctgtaaacaa tgccttcagc tacactgctt ctggcacctc   1380

tgctggatcc agtacattgc gggatgtggt tcccagtcca gacacgcagg agaaaggtgc   1440

tcaagaggtc ccttttccta agactgagga agtagagagt gccatctcaa atggtgtgac   1500

tggccagctt aatattgtcc agtacataaa accagaacca gatggagctt ttagcagctc   1560

atgtctagga ggaaatagca aaataaattc ggattcttca ttctcagtac caataaagca   1620

agaatcaacc aagcattcat gttcaggcac ctcttttaaa gggaatccaa cagtaaaccc   1680

gtttccattt atggatggct cgtatttttc ctttatggat gataaagact attattccct   1740

atcaggaatt ttaggaccac ctgtgcccgg ctttgatggt aactgtgaag gcagcggatt   1800

cccagtgggt attaaacaag aaccagatga tgggagctat tacccagagg ccagcatccc   1860

ttcctctgct attgttgggg tgaattcagg tggacagtcc ttccactaca ggattggtgc   1920

tcaaggtaca atatctttat cacgatcggc tagagaccaa tctttccaac acctgagttc   1980

ctttcctcct gtcaatactt tagtggagtc atggaaatca cacggcgacc tgtcgtctag   2040

aagaagtgat gggtatccgg tcttagaata cattccagaa aatgtatcaa gctctacttt   2100

acgaagtgtt tctactggat cttcaagacc ttcaaaaata tgtttggtgt gtggggatga   2160

ggcttcagga tgccattatg gggtagtcac ctgtggcagc tgcaaagttt tcttcaaaag   2220

agcagtggaa gggcaacaca actatttatg tgctggaaga aatgattgca tcattgataa   2280

gattcgacga aagaattgtc ctgcttgcag acttcagaaa tgtcttcaag ctggaatgaa   2340

tttaggagca cgaaagtcaa agaagttggg aaagttaaaa gggattcacg aggagcagcc   2400

acagcagcag cagcccccac ccccaccccc acccccgcaa agcccagagg aagggacaac   2460

gtacatcgct cctgcaaaag aaccctcggt caacacagca ctggttcctc agctctccac   2520

aatctcacga gcgctcacac cttcccccgt tatggtcctt gaaaacattg aacctgaaat   2580

tgtatatgca ggctatgaca gctcaaaacc agatacagcc gaaaatctgc tctccacgct   2640

caaccgctta gcaggcaaac agatgatcca agtcgtgaag tgggcaaagg tacttccagg   2700

atttaaaaac ttgcctcttg aggaccaaat taccctaatc cagtattctt ggatgtgtct   2760

atcatcattt gccttgagct ggagatcgta caaacatacg aacagccaat ttctctattt   2820

tgcaccagac ctagtcttta atgaagagaa gatgcatcag tctgccatgt atgaactatg   2880

ccaggggatg caccaaatca gccttcagtt cgttcgactg cagctcacct ttgaagaata   2940

caccatcatg aaagttttgc tgctactaag cacaattcca aaggatggcc tcaaaagcca   3000

ggctgcattt gaagaaatga ggacaaatta catcaaagaa ctgaggaaga tggtaactaa   3060

gtgtcccaac aattctgggc agagctggca gaggttctac caactgacca agctgctgga   3120

ctccatgcat gacctggtga gcgacctgct ggaattctgc ttctacacct tccgagagtc   3180

ccatgcgctg aaggtagagt tccccgcaat gctggtggag atcatcagcg accagctgcc   3240

caaggtggag tcggggaacg ccaagccgct ctacttccac cggaagtgac tgcccgctgc   3300

ccagaagaac tttgccttaa gtttccctgt gttgttccac acccagaagg acccaagaaa   3360

acctgttttt aacatgtgat ggttgattca cacttgttca acagtttctc aagtttaaag   3420

tcatgtcaga ggtttggagc cgggaaagct gtttttccgt ggatttggcg agaccagagc   3480

agtctgaagg attccccacc tccaatcccc cagcgcttag aaacatgttc ctgttcctcg   3540

ggatgaaaag ccatatctag tcaataactc tgattttgat attttcacag atggaagaag   3600

ttttaactat gccgtgtagt ttctggtatc gttcgcttgt tttaaaaggg ttcaaggact   3660

aacgaacgtt ttaaagctta cccttggttt gcacataaaa cgtatagtca atatggggca   3720

ttaatattct tttgttatta aaaaaacaca aaaaaataat aaaaaaatat atacagattc   3780

ctgttgtgta ataacagaac tcgtggcgtg gggcagcagc tgcctctgag ccctcgctcg   3840

tccacggtct tctgcatcac tggtatacac actcgttagc gtccatttct tatttaatta   3900

gaatggataa gatgatgtta aatgccttgg tttgatttct agtatctatt gtgttggctt   3960

tacaaataat tttttgcagt cttttgctgt gctgtacatt actgtatgta taaattatga   4020

aggacctgaa ataaggtata aggatctttt gtaaatgaga cacatacaaa aaaaatcttt   4080

aatggttaat aggatgaatg ggaaagtatt tttgaaagaa ttctattttg ctggagacta   4140

tttaagtact atctttgtct aaacaaggta attttttttt gtaaagtgca atgtcctgca   4200

tgcataatga accgtttaca gtgtatttaa gaaagggaaa gctgtgcctt ttttagcttc   4260

atatctaatt taccattatt ttacagtctc tgttgtaaat aaccacactg aaacctcttc   4320

ggttgtcttg aaacctttct actttttctg tactttttgt tttgttcttg gtctcccgct   4380

tggggcattt gtgggactcc agcacgtttt ctggcttctg cttcatcctg ctccatcggg   4440

gaatgacaca ctgcggtgtc tgcagctcct ggaaggtgtc atttgacaac acatgtggga   4500

gaggaggtcc ttggagtgct gcagctttgg gaaagctgcc tcgtttccct tttcctctag   4560

aagcagaacc agctctacga gagtgagact gggaacttga tggctcagag agcatctttt   4620

cctcccattt tagaaaatca gattttctcc tgtgggaaaa aaaaattcca tgcactctct   4680

ctctgttaaa gatcagctat tcccttctga tcttggaaag aggttctgca ctcctggaac   4740

cggtcacagg aacgcacaga tcatggcagg atgcgctggg acggcccatc ttggcaaggt   4800

tcagtctgaa tggcatggag accgggagat agaggggttt tagattttta aaaggtaggt   4860

tttaaaaata agttttatac ataaacagtt ttggagaaaa attacagatc atataagcaa   4920

gacagtggca ctaaaatgtt taattcatta atctgtttgt ttggcactga tgcaatgtat   4980

ggcttttctc ttgccccaaa tcacaaacat atgtatcttt ggggaaacta acaatatgat   5040

tgcactaaat aaactacttt gaatagaggc caaattaatc ttttaaaaat gatgataatc   5100

atcaggttta ctcagtgaaa tcatattaat tattttccaa aatctaaaag ctgtagctgg   5160

agaagcccat ggccacgagg aagcagcaat taattagatc aacacttttc tccagggttc   5220

accatgcagg caacattacc ttgtctttca aaagacacct gccttatgca aggggaaacc   5280

tgtgaaagct gcactcagag ggaggagttt ttcttacata atttgcaatt tcaggaattt   5340

aatttatagg cagatcttta aatacagtca acttacggtg cacagtaata tgaaagccac   5400

actttgaagg taataaatac acagcatgca gactgggagt tgctagcaaa caaatggctt   5460

acttacaaaa gcagctttta gttcagactt agtttttata aaatgggaat tctgacttac   5520

ttaaccaggt ttgggatgga gatggtctgc atcagctttt tgtattaaca aagttactgg   5580

ctctttgtgt gtctccaggt aactttgctt gattaaacag caaagccata ttctaaattc   5640

actgttgaat gcctgtccca gtccaaattg tctgtctgct cttatttttg taccatattg   5700

ctcttaaaaa tcttggtttg gtacagttca taattcacca aaagttcata taatttaaag   5760

aaacactaaa ttagtttaaa atgaagcaat ttatatcttt atgcaaaaac atatgtctgt   5820

ctttgcaaag gactgtaagc agattacaat aaatccttta ctttaatca               5869


<210>  250
<211>  984
<212>  PRT
<213>  Homo sapiens

<400>  250

Met Glu Thr Lys Gly Tyr His Ser Leu Pro Glu Gly Leu Asp Met Glu 
1               5                   10                  15


Arg Arg Trp Gly Gln Val Ser Gln Ala Val Glu Arg Ser Ser Leu Gly 
            20                  25                  30


Pro Thr Glu Arg Thr Asp Glu Asn Asn Tyr Met Glu Ile Val Asn Val 
        35                  40                  45


Ser Cys Val Ser Gly Ala Ile Pro Asn Asn Ser Thr Gln Gly Ser Ser 
    50                  55                  60


Lys Glu Lys Gln Glu Leu Leu Pro Cys Leu Gln Gln Asp Asn Asn Arg 
65                  70                  75                  80


Pro Gly Ile Leu Thr Ser Asp Ile Lys Thr Glu Leu Glu Ser Lys Glu 
                85                  90                  95


Leu Ser Ala Thr Val Ala Glu Ser Met Gly Leu Tyr Met Asp Ser Val 
            100                 105                 110


Arg Asp Ala Asp Tyr Ser Tyr Glu Gln Gln Asn Gln Gln Gly Ser Met 
        115                 120                 125


Ser Pro Ala Lys Ile Tyr Gln Asn Val Glu Gln Leu Val Lys Phe Tyr 
    130                 135                 140


Lys Gly Asn Gly His Arg Pro Ser Thr Leu Ser Cys Val Asn Thr Pro 
145                 150                 155                 160


Leu Arg Ser Phe Met Ser Asp Ser Gly Ser Ser Val Asn Gly Gly Val 
                165                 170                 175


Met Arg Ala Val Val Lys Ser Pro Ile Met Cys His Glu Lys Ser Pro 
            180                 185                 190


Ser Val Cys Ser Pro Leu Asn Met Thr Ser Ser Val Cys Ser Pro Ala 
        195                 200                 205


Gly Ile Asn Ser Val Ser Ser Thr Thr Ala Ser Phe Gly Ser Phe Pro 
    210                 215                 220


Val His Ser Pro Ile Thr Gln Gly Thr Pro Leu Thr Cys Ser Pro Asn 
225                 230                 235                 240


Val Glu Asn Arg Gly Ser Arg Ser His Ser Pro Ala His Ala Ser Asn 
                245                 250                 255


Val Gly Ser Pro Leu Ser Ser Pro Leu Ser Ser Met Lys Ser Ser Ile 
            260                 265                 270


Ser Ser Pro Pro Ser His Cys Ser Val Lys Ser Pro Val Ser Ser Pro 
        275                 280                 285


Asn Asn Val Thr Leu Arg Ser Ser Val Ser Ser Pro Ala Asn Ile Asn 
    290                 295                 300


Asn Ser Arg Cys Ser Val Ser Ser Pro Ser Asn Thr Asn Asn Arg Ser 
305                 310                 315                 320


Thr Leu Ser Ser Pro Ala Ala Ser Thr Val Gly Ser Ile Cys Ser Pro 
                325                 330                 335


Val Asn Asn Ala Phe Ser Tyr Thr Ala Ser Gly Thr Ser Ala Gly Ser 
            340                 345                 350


Ser Thr Leu Arg Asp Val Val Pro Ser Pro Asp Thr Gln Glu Lys Gly 
        355                 360                 365


Ala Gln Glu Val Pro Phe Pro Lys Thr Glu Glu Val Glu Ser Ala Ile 
    370                 375                 380


Ser Asn Gly Val Thr Gly Gln Leu Asn Ile Val Gln Tyr Ile Lys Pro 
385                 390                 395                 400


Glu Pro Asp Gly Ala Phe Ser Ser Ser Cys Leu Gly Gly Asn Ser Lys 
                405                 410                 415


Ile Asn Ser Asp Ser Ser Phe Ser Val Pro Ile Lys Gln Glu Ser Thr 
            420                 425                 430


Lys His Ser Cys Ser Gly Thr Ser Phe Lys Gly Asn Pro Thr Val Asn 
        435                 440                 445


Pro Phe Pro Phe Met Asp Gly Ser Tyr Phe Ser Phe Met Asp Asp Lys 
    450                 455                 460


Asp Tyr Tyr Ser Leu Ser Gly Ile Leu Gly Pro Pro Val Pro Gly Phe 
465                 470                 475                 480


Asp Gly Asn Cys Glu Gly Ser Gly Phe Pro Val Gly Ile Lys Gln Glu 
                485                 490                 495


Pro Asp Asp Gly Ser Tyr Tyr Pro Glu Ala Ser Ile Pro Ser Ser Ala 
            500                 505                 510


Ile Val Gly Val Asn Ser Gly Gly Gln Ser Phe His Tyr Arg Ile Gly 
        515                 520                 525


Ala Gln Gly Thr Ile Ser Leu Ser Arg Ser Ala Arg Asp Gln Ser Phe 
    530                 535                 540


Gln His Leu Ser Ser Phe Pro Pro Val Asn Thr Leu Val Glu Ser Trp 
545                 550                 555                 560


Lys Ser His Gly Asp Leu Ser Ser Arg Arg Ser Asp Gly Tyr Pro Val 
                565                 570                 575


Leu Glu Tyr Ile Pro Glu Asn Val Ser Ser Ser Thr Leu Arg Ser Val 
            580                 585                 590


Ser Thr Gly Ser Ser Arg Pro Ser Lys Ile Cys Leu Val Cys Gly Asp 
        595                 600                 605


Glu Ala Ser Gly Cys His Tyr Gly Val Val Thr Cys Gly Ser Cys Lys 
    610                 615                 620


Val Phe Phe Lys Arg Ala Val Glu Gly Gln His Asn Tyr Leu Cys Ala 
625                 630                 635                 640


Gly Arg Asn Asp Cys Ile Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro 
                645                 650                 655


Ala Cys Arg Leu Gln Lys Cys Leu Gln Ala Gly Met Asn Leu Gly Ala 
            660                 665                 670


Arg Lys Ser Lys Lys Leu Gly Lys Leu Lys Gly Ile His Glu Glu Gln 
        675                 680                 685


Pro Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Gln Ser Pro 
    690                 695                 700


Glu Glu Gly Thr Thr Tyr Ile Ala Pro Ala Lys Glu Pro Ser Val Asn 
705                 710                 715                 720


Thr Ala Leu Val Pro Gln Leu Ser Thr Ile Ser Arg Ala Leu Thr Pro 
                725                 730                 735


Ser Pro Val Met Val Leu Glu Asn Ile Glu Pro Glu Ile Val Tyr Ala 
            740                 745                 750


Gly Tyr Asp Ser Ser Lys Pro Asp Thr Ala Glu Asn Leu Leu Ser Thr 
        755                 760                 765


Leu Asn Arg Leu Ala Gly Lys Gln Met Ile Gln Val Val Lys Trp Ala 
    770                 775                 780


Lys Val Leu Pro Gly Phe Lys Asn Leu Pro Leu Glu Asp Gln Ile Thr 
785                 790                 795                 800


Leu Ile Gln Tyr Ser Trp Met Cys Leu Ser Ser Phe Ala Leu Ser Trp 
                805                 810                 815


Arg Ser Tyr Lys His Thr Asn Ser Gln Phe Leu Tyr Phe Ala Pro Asp 
            820                 825                 830


Leu Val Phe Asn Glu Glu Lys Met His Gln Ser Ala Met Tyr Glu Leu 
        835                 840                 845


Cys Gln Gly Met His Gln Ile Ser Leu Gln Phe Val Arg Leu Gln Leu 
    850                 855                 860


Thr Phe Glu Glu Tyr Thr Ile Met Lys Val Leu Leu Leu Leu Ser Thr 
865                 870                 875                 880


Ile Pro Lys Asp Gly Leu Lys Ser Gln Ala Ala Phe Glu Glu Met Arg 
                885                 890                 895


Thr Asn Tyr Ile Lys Glu Leu Arg Lys Met Val Thr Lys Cys Pro Asn 
            900                 905                 910


Asn Ser Gly Gln Ser Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
        915                 920                 925


Asp Ser Met His Asp Leu Val Ser Asp Leu Leu Glu Phe Cys Phe Tyr 
    930                 935                 940


Thr Phe Arg Glu Ser His Ala Leu Lys Val Glu Phe Pro Ala Met Leu 
945                 950                 955                 960


Val Glu Ile Ile Ser Asp Gln Leu Pro Lys Val Glu Ser Gly Asn Ala 
                965                 970                 975


Lys Pro Leu Tyr Phe His Arg Lys 
            980


<210>  251
<211>  2874
<212>  DNA
<213>  Homo sapiens

<400>  251
atgagcacca atcgcctacg ggaggccaga aaaggctgcg tggtgctccc ctctcagggc     60

ctggccctgt ccacctgggc cttggtgacc cgcagccggg actcttgctg taaagtgacg    120

cagtgctctc cctgggagga caaaagaatc cccggagtag agaaggaggc cagcgagtct    180

cagttcgctg ctcgctcaga gccgcccagg tgcgagggcg tcttcaccag aaatcggtgc    240

tcccgcgcgc cccaccctcc ggggccctgc agatgccggg tcgggggccg ccagcaggcc    300

ctttggctcc tgctggagac actggaagac caggcgacca ggacagcggg tcgggccagt    360

gcgcttgccc agcggcacgt gggcctcaag cctggtcccc agcggctgcg ccagcctagc    420

tgtgttcacc ttggggccgc gagggcctcc caccggctgg cagctggtgg acacgctgtc    480

aagatcgggg gaaaaaaagg aaggaaggag gctaggggga cacagggctg gtggcctccg    540

cagtctttga cctgcgacgg gcgcgagcgc acctccgcgc ctttgcgcag agaccttccc    600

ccaagattgg ctcacgacgc ctcctacccc gaagtcaagg gctccctgtg gcaaatcctc    660

acacgccctc ctcctccccg cccatccccg gcgccaggac tgacggggag agggcaaggc    720

cgggccagag gggctgtggg cctggactgc ggctgtcgcc cgcggccctg ctcttttggg    780

cagccagacg tggggtcagc gcccagtcgc agcctccggg gatgctccct gaggttccgg    840

aacaccccgc cccccatccc aggatctgac caaccctcaa gccacggccg gccccggttc    900

cgcgagacgg gggactctga ggattgtcct cccttccggg ctgggactcc cccacagcag    960

ccgaccgccc ccagttcaga gtggcccggc ccgcagcgct ccccgggcac aggtcccagg   1020

tggacggctc cgctcccgcg cccggctcct ctgcccgcca agcgccccgg ggattccccg   1080

gcctccaagc ggccgcggcc gggtggagtc agccccgaag cccgggatcc cccgaaggga   1140

gaaaacccgc tctgctcctc tgaagcggcg ggagaaaccg gccccaccca ggtccggggg   1200

cccgacgccc tcggcggagg ccggctccag gggtccgagc cgcctggtgc cggtttccgc   1260

cgagctggag cgcgcgggcc acggcttctc tggggacgca gaagcgagaa gcggggacct   1320

cggcgcgcgc cccgcgtccc gctcttcctg cccgcgcccc ggcccccggc ccgcgccccg   1380

gccgccggca tggtgctgct ggccgggacc gggccggagg gcggcggggc gcgctgcatg   1440

accccaccac cgccgtcccc accccggggc gcgcaggtcg aggaggaccc cgctgactac   1500

gaagagtttg aggacttctc gagtctgcca gacacccgca gcatcgcctc ggacgactct   1560

ttctaccctt tcgaggacga ggaggagcac ggcgtcgaga gcgcggagag cgtcccggag   1620

ggcgtcccgg aaagcgtccc ggagacggcg accctcctgc gcgccgcctg cgccaacaac   1680

gtggggctgc tgcggacgct ggtgcggcgc ggggtgagcg tcgaggaggc gcaggagact   1740

gaccgcaacg gcaggaccgg ccttattgtc gcctgctacc acggctttgt ggataccgtg   1800

gtggccttag cagagtgccc ccacgttgac gtcaactggc aggacagcga ggggaacaca   1860

gccctaatca cagctgcaca ggcagggcac gctatcatca ctaactactt gttgaactat   1920

ttccctggtc ttgaccttga aaggaggaac gcgttcgggt tcaccgccct gatgaaagcc   1980

gccatgcagg gtcgaacgga ctgcatccga gccctgatgc tagcaggggc ggatgtccac   2040

gcgagggacc cccgccgtgg gatgtcgccg caggagtggg ccacttacac gggccgcgtg   2100

gatgccgtcc gtctcatgca gaggctgctg gagcgcccct gcccggagca gttctgggag   2160

aagtaccggc ccgagctgcc gccgccccct gaagcggcgc ggaagcccgc gggctccaag   2220

aactgcctgc agaggctcac agactgcgtg ctgtccgtgc tgacgccgcg ctccgtgcgg   2280

ggcccggagg acgggggcgt cctggaccac atggtccgga tgaccacgag cctctacagc   2340

cccgccgtgg ccatcgtgtg ccagaccgtg tgccctgaga gccctccgag cgtggggaag   2400

aggcggctgg cggtgcagga gatcctggcg gcgcgggctg cacggggccc ccaggcgcag   2460

gaggaggatg aggtgggggg cgcggggcag cgcgggcgga ccggacagga ggacgcggac   2520

tcccgggagg gctccccgag agccggcctc cctcccgccc tggggtcccg gggccccgca   2580

gcgcccgccc cgcggaaggc cagcctcctg cccctgcagc gcctgcggcg gagaagcgtg   2640

cggcccggtg tggtggtgcc ccgggtccga gtcagcaagg cgcccgcgcc caccttccag   2700

cccgagcggc cggcgcggaa gggcagcacc aaggacagcg gccacctgca gatccccaag   2760

tggcggtaca aggaggccaa ggaggagaag aggaaggcag aggaggccga aaagaagcgc   2820

caggccgagg cgcagaagga gaggcgcact gcgccctgga agaagaggac gtga         2874


<210>  252
<211>  957
<212>  PRT
<213>  Homo sapiens

<400>  252

Met Ser Thr Asn Arg Leu Arg Glu Ala Arg Lys Gly Cys Val Val Leu 
1               5                   10                  15


Pro Ser Gln Gly Leu Ala Leu Ser Thr Trp Ala Leu Val Thr Arg Ser 
            20                  25                  30


Arg Asp Ser Cys Cys Lys Val Thr Gln Cys Ser Pro Trp Glu Asp Lys 
        35                  40                  45


Arg Ile Pro Gly Val Glu Lys Glu Ala Ser Glu Ser Gln Phe Ala Ala 
    50                  55                  60


Arg Ser Glu Pro Pro Arg Cys Glu Gly Val Phe Thr Arg Asn Arg Cys 
65                  70                  75                  80


Ser Arg Ala Pro His Pro Pro Gly Pro Cys Arg Cys Arg Val Gly Gly 
                85                  90                  95


Arg Gln Gln Ala Leu Trp Leu Leu Leu Glu Thr Leu Glu Asp Gln Ala 
            100                 105                 110


Thr Arg Thr Ala Gly Arg Ala Ser Ala Leu Ala Gln Arg His Val Gly 
        115                 120                 125


Leu Lys Pro Gly Pro Gln Arg Leu Arg Gln Pro Ser Cys Val His Leu 
    130                 135                 140


Gly Ala Ala Arg Ala Ser His Arg Leu Ala Ala Gly Gly His Ala Val 
145                 150                 155                 160


Lys Ile Gly Gly Lys Lys Gly Arg Lys Glu Ala Arg Gly Thr Gln Gly 
                165                 170                 175


Trp Trp Pro Pro Gln Ser Leu Thr Cys Asp Gly Arg Glu Arg Thr Ser 
            180                 185                 190


Ala Pro Leu Arg Arg Asp Leu Pro Pro Arg Leu Ala His Asp Ala Ser 
        195                 200                 205


Tyr Pro Glu Val Lys Gly Ser Leu Trp Gln Ile Leu Thr Arg Pro Pro 
    210                 215                 220


Pro Pro Arg Pro Ser Pro Ala Pro Gly Leu Thr Gly Arg Gly Gln Gly 
225                 230                 235                 240


Arg Ala Arg Gly Ala Val Gly Leu Asp Cys Gly Cys Arg Pro Arg Pro 
                245                 250                 255


Cys Ser Phe Gly Gln Pro Asp Val Gly Ser Ala Pro Ser Arg Ser Leu 
            260                 265                 270


Arg Gly Cys Ser Leu Arg Phe Arg Asn Thr Pro Pro Pro Ile Pro Gly 
        275                 280                 285


Ser Asp Gln Pro Ser Ser His Gly Arg Pro Arg Phe Arg Glu Thr Gly 
    290                 295                 300


Asp Ser Glu Asp Cys Pro Pro Phe Arg Ala Gly Thr Pro Pro Gln Gln 
305                 310                 315                 320


Pro Thr Ala Pro Ser Ser Glu Trp Pro Gly Pro Gln Arg Ser Pro Gly 
                325                 330                 335


Thr Gly Pro Arg Trp Thr Ala Pro Leu Pro Arg Pro Ala Pro Leu Pro 
            340                 345                 350


Ala Lys Arg Pro Gly Asp Ser Pro Ala Ser Lys Arg Pro Arg Pro Gly 
        355                 360                 365


Gly Val Ser Pro Glu Ala Arg Asp Pro Pro Lys Gly Glu Asn Pro Leu 
    370                 375                 380


Cys Ser Ser Glu Ala Ala Gly Glu Thr Gly Pro Thr Gln Val Arg Gly 
385                 390                 395                 400


Pro Asp Ala Leu Gly Gly Gly Arg Leu Gln Gly Ser Glu Pro Pro Gly 
                405                 410                 415


Ala Gly Phe Arg Arg Ala Gly Ala Arg Gly Pro Arg Leu Leu Trp Gly 
            420                 425                 430


Arg Arg Ser Glu Lys Arg Gly Pro Arg Arg Ala Pro Arg Val Pro Leu 
        435                 440                 445


Phe Leu Pro Ala Pro Arg Pro Pro Ala Arg Ala Pro Ala Ala Gly Met 
    450                 455                 460


Val Leu Leu Ala Gly Thr Gly Pro Glu Gly Gly Gly Ala Arg Cys Met 
465                 470                 475                 480


Thr Pro Pro Pro Pro Ser Pro Pro Arg Gly Ala Gln Val Glu Glu Asp 
                485                 490                 495


Pro Ala Asp Tyr Glu Glu Phe Glu Asp Phe Ser Ser Leu Pro Asp Thr 
            500                 505                 510


Arg Ser Ile Ala Ser Asp Asp Ser Phe Tyr Pro Phe Glu Asp Glu Glu 
        515                 520                 525


Glu His Gly Val Glu Ser Ala Glu Ser Val Pro Glu Gly Val Pro Glu 
    530                 535                 540


Ser Val Pro Glu Thr Ala Thr Leu Leu Arg Ala Ala Cys Ala Asn Asn 
545                 550                 555                 560


Val Gly Leu Leu Arg Thr Leu Val Arg Arg Gly Val Ser Val Glu Glu 
                565                 570                 575


Ala Gln Glu Thr Asp Arg Asn Gly Arg Thr Gly Leu Ile Val Ala Cys 
            580                 585                 590


Tyr His Gly Phe Val Asp Thr Val Val Ala Leu Ala Glu Cys Pro His 
        595                 600                 605


Val Asp Val Asn Trp Gln Asp Ser Glu Gly Asn Thr Ala Leu Ile Thr 
    610                 615                 620


Ala Ala Gln Ala Gly His Ala Ile Ile Thr Asn Tyr Leu Leu Asn Tyr 
625                 630                 635                 640


Phe Pro Gly Leu Asp Leu Glu Arg Arg Asn Ala Phe Gly Phe Thr Ala 
                645                 650                 655


Leu Met Lys Ala Ala Met Gln Gly Arg Thr Asp Cys Ile Arg Ala Leu 
            660                 665                 670


Met Leu Ala Gly Ala Asp Val His Ala Arg Asp Pro Arg Arg Gly Met 
        675                 680                 685


Ser Pro Gln Glu Trp Ala Thr Tyr Thr Gly Arg Val Asp Ala Val Arg 
    690                 695                 700


Leu Met Gln Arg Leu Leu Glu Arg Pro Cys Pro Glu Gln Phe Trp Glu 
705                 710                 715                 720


Lys Tyr Arg Pro Glu Leu Pro Pro Pro Pro Glu Ala Ala Arg Lys Pro 
                725                 730                 735


Ala Gly Ser Lys Asn Cys Leu Gln Arg Leu Thr Asp Cys Val Leu Ser 
            740                 745                 750


Val Leu Thr Pro Arg Ser Val Arg Gly Pro Glu Asp Gly Gly Val Leu 
        755                 760                 765


Asp His Met Val Arg Met Thr Thr Ser Leu Tyr Ser Pro Ala Val Ala 
    770                 775                 780


Ile Val Cys Gln Thr Val Cys Pro Glu Ser Pro Pro Ser Val Gly Lys 
785                 790                 795                 800


Arg Arg Leu Ala Val Gln Glu Ile Leu Ala Ala Arg Ala Ala Arg Gly 
                805                 810                 815


Pro Gln Ala Gln Glu Glu Asp Glu Val Gly Gly Ala Gly Gln Arg Gly 
            820                 825                 830


Arg Thr Gly Gln Glu Asp Ala Asp Ser Arg Glu Gly Ser Pro Arg Ala 
        835                 840                 845


Gly Leu Pro Pro Ala Leu Gly Ser Arg Gly Pro Ala Ala Pro Ala Pro 
    850                 855                 860


Arg Lys Ala Ser Leu Leu Pro Leu Gln Arg Leu Arg Arg Arg Ser Val 
865                 870                 875                 880


Arg Pro Gly Val Val Val Pro Arg Val Arg Val Ser Lys Ala Pro Ala 
                885                 890                 895


Pro Thr Phe Gln Pro Glu Arg Pro Ala Arg Lys Gly Ser Thr Lys Asp 
            900                 905                 910


Ser Gly His Leu Gln Ile Pro Lys Trp Arg Tyr Lys Glu Ala Lys Glu 
        915                 920                 925


Glu Lys Arg Lys Ala Glu Glu Ala Glu Lys Lys Arg Gln Ala Glu Ala 
    930                 935                 940


Gln Lys Glu Arg Arg Thr Ala Pro Trp Lys Lys Arg Thr 
945                 950                 955


<210>  253
<211>  4164
<212>  DNA
<213>  Homo sapiens

<400>  253
cgcctaatct tcacccgctg ctaggctcgt ttaatgagtc ttctgagagc taaggagtcc     60

tcggattcat tcaaagcatt ctacaatgaa cgctaggggg gaaaaagaac aaacaaaata    120

catttcaaat ataggattca attacttttc actactcaat gatgtgtcaa aggcacgctg    180

tgttttgttt tgagggcggg gagatgacag gagggaatcc tgggccccca ttggctcgcc    240

gctcgccgct gcagttgagc tccagccgct ccgagagcat tattgatctg aagggtaaat    300

gtggagggag ccacagagag gggtccaggc ttttctgaga agagaggcag cctcttccag    360

gaagaaagtg gtgtctactg gctgcccggc ctggagaacc ttctttgaat gaaaacggac    420

aaaatgcaaa gcagtgtgtt ggcacagtga tttggaaagg ggaaacagaa gagaagggtc    480

tcaccttccg cgcaaggctg agctgttggc accctgctgc ggccgtcggt gctgctgctc    540

ctgcagctgc cttttctgcc atcagctttg ttacctaaca gcttggctct tttgggaaat    600

atagacaagc tggaacccag gagcagttgg gagttttaaa gaatgccagc ctttttaaag    660

ctttgatgtc cagtgctata gaatcaagtt actgtggagg tcaaaacaat ttgagataca    720

taagctggcc ttagaaaata aattgcctct aacttacagt gaggagctca acataacagg    780

gaaaaggagc acaggatgca gctacttgga gggtgttgat tgaaaacttc gatctcccca    840

ccccattcac ggttgatttg acggatttct caccttgttc acagagaaaa tttcaattaa    900

ggccccttta gatggaatat aatacagcag aagccttttc atcaaaagga ttaatgcctg    960

catcatcatt tctgcaataa aacaagaagc taagcggtgg aggccacaga cacctcaaac   1020

ctggattcca caattctacg ttaagtgttg gagtttttat tactctgctg taggaaagcc   1080

tttgccaatg cttacaagga actgtttatc cctgcttctc tgggttctgt ttgatggagg   1140

tctcctaaca ccactacaac cacagccaca gcagacttta gccacagagc caagagaaaa   1200

tgttatccat ctgccaggac aacggtcaca tttccaacgt gttaaacgtg gctgggtatg   1260

gaatcaattt tttgtgctgg aagaatacgt gggctccgag cctcagtatg tgggaaagct   1320

ccattccgac ttagacaagg gagagggcac tgtgaaatac accctctcag gagatggcgc   1380

tggcaccgtt tttaccattg atgaaaccac aggggacatt catgcaataa ggagcctaga   1440

tagagaagag aaacctttct acactcttcg tgctcaggct gtggacatag aaaccagaaa   1500

gcccctggag cctgaatcag aattcatcat caaagtgcag gatattaatg ataatgagcc   1560

aaagtttttg gatggacctt atgttgctac tgttccagaa atgtctcctg tgggtgcata   1620

tgtactccag gtcaaggcca cagatgcaga tgacccgacc tatggaaaca gtgccagagt   1680

cgtttacagc attcttcagg gacaacctta tttctctatt gatcccaaga caggtgttat   1740

tagaacagct ttgccaaaca tggacagaga agtcaaagaa caatatcaag tactcatcca   1800

agccaaggat atgggaggac agcttggagg attagccgga acaacaatag tcaacatcac   1860

tctcaccgat gtcaatgaca atccacctcg attccccaaa agcatcttcc acttgaaagt   1920

tcctgagtct tcccctattg gttcagctat tggaagaata agagctgtgg atcctgattt   1980

tggacaaaat gcagaaattg aatacaatat tgttccagga gatgggggaa atttgtttga   2040

catcgtcaca gatgaggata cacaagaggg agtcatcaaa ttgaaaaagc ctttagattt   2100

tgaaacaaag aaggcataca ctttcaaagt tgaggcttcc aaccttcacc ttgaccaccg   2160

gtttcactcg gcgggccctt tcaaagacac agctacggtg aagatcagcg tgctggacgt   2220

agatgagcca ccggttttca gcaagccgct ctacaccatg gaggtttatg aagacactcc   2280

ggtagggacc atcattggcg ctgtcactgc tcaagacctg gatgtaggca gcagtgctgt   2340

taggtacttc atagattgga agagtgatgg ggacagctac tttacaatag atggaaatga   2400

aggaaccatc gccactaatg aattactaga cagagaaagc actgcgcagt ataatttctc   2460

cataattgcg agtaaagtta gtaacccttt attgaccagc aaagtcaata tactgattaa   2520

tgtcttagat gtaaatgaat ttcctccaga aatatctgtg ccatatgaga cagccgtgtg   2580

tgaaaatgcc aagccaggac agataattca gatagtcagt gctgcagacc gagatctttc   2640

acctgctggg caacaattct cctttagatt atcacctgag gctgctatca aaccaaattt   2700

tacagttcgt gacttcagaa acaacacagc ggggattgaa acccgaagaa atggatacag   2760

ccgcaggcag caagagttgt atttcctccc tgttgtaata gaagacagca gctaccctgt   2820

ccagagcagc acaaacacaa tgactattcg agtctgtaga tgtgactctg atggcaccat   2880

cctgtcttgt aatgtggaag caatttttct acctgtagga cttagcactg gggcgttgat   2940

tgcaattcta ctatgcattg ttatactctt agccatagtt gtactgtatg tagcactgcg   3000

aaggcagaag aaaaaagaca ccctgatgac ctctaaagaa gacatcagag acaacgtcat   3060

ccattacgat gatgaaggag gtggggagga agatacccag gctttcgaca tcggggctct   3120

gagaaaccca aaagtgattg aggagaacaa aattcgcagg gatataaaac cagactctct   3180

ctgtttacct cgtcagagac cacccatgga agataacaca gacataaggg atttcattca   3240

tcaaaggcta caggaaaatg acgtggaccc aactgcccca ccatacgatt cactggccac   3300

atatgcctac gaagggagtg ggtccgtggc agagtccctc agctctatag actctctcac   3360

cacagaagcc gaccaggact atgactatct gacagactgg ggaccccgct ttaaagtctt   3420

ggcagacatg tttggcgaag aagagagtta taaccctgat aaagtcactt aagggagtcg   3480

tggaggctaa aatacaaccg agaggggaga tttttaaaaa agaaaaagaa acacaaatat   3540

taatagaaat ctctctcaca cacacacaca cacacaaaca cacacacaca cacacactct   3600

ttctgggaca agattccttt gattacctgg tttctagtaa gttactaaat taatcatatt   3660

gtcagttttg gtttattctg ccaacaagag atacatccta taatgtgtac ttgctttgtt   3720

ttgttgtttt gttttttcac aatcacactg agacaagctc aggcctattc aatacaattt   3780

actgacatga caacctagaa cgaagatagc tatgtggcat cacggtggaa gagtgttaga   3840

tttttcttaa ttccactaaa gtgcctattg aaactcttat catttaaagt ggtgtacagt   3900

acactctgct gtgatggtat tgcgggattc agagataaag acataaaaca gacaccgtct   3960

ttatgtcaag aagcaatagc gacactctga ctctcctcat tccttttgag aacaaaagaa   4020

gaacactttc tgatctccac cttcttctaa ttcaaaaggt tttctttttc ttttttaaac   4080

tgtatgctaa aacgtatttg tttatcctat cctttcagaa aattgaaata aatatgaaaa   4140

tatcaagttc aatatgtaag tccc                                          4164


<210>  254
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  254

Met Leu Thr Arg Asn Cys Leu Ser Leu Leu Leu Trp Val Leu Phe Asp 
1               5                   10                  15


Gly Gly Leu Leu Thr Pro Leu Gln Pro Gln Pro Gln Gln Thr Leu Ala 
            20                  25                  30


Thr Glu Pro Arg Glu Asn Val Ile His Leu Pro Gly Gln Arg Ser His 
        35                  40                  45


Phe Gln Arg Val Lys Arg Gly Trp Val Trp Asn Gln Phe Phe Val Leu 
    50                  55                  60


Glu Glu Tyr Val Gly Ser Glu Pro Gln Tyr Val Gly Lys Leu His Ser 
65                  70                  75                  80


Asp Leu Asp Lys Gly Glu Gly Thr Val Lys Tyr Thr Leu Ser Gly Asp 
                85                  90                  95


Gly Ala Gly Thr Val Phe Thr Ile Asp Glu Thr Thr Gly Asp Ile His 
            100                 105                 110


Ala Ile Arg Ser Leu Asp Arg Glu Glu Lys Pro Phe Tyr Thr Leu Arg 
        115                 120                 125


Ala Gln Ala Val Asp Ile Glu Thr Arg Lys Pro Leu Glu Pro Glu Ser 
    130                 135                 140


Glu Phe Ile Ile Lys Val Gln Asp Ile Asn Asp Asn Glu Pro Lys Phe 
145                 150                 155                 160


Leu Asp Gly Pro Tyr Val Ala Thr Val Pro Glu Met Ser Pro Val Gly 
                165                 170                 175


Ala Tyr Val Leu Gln Val Lys Ala Thr Asp Ala Asp Asp Pro Thr Tyr 
            180                 185                 190


Gly Asn Ser Ala Arg Val Val Tyr Ser Ile Leu Gln Gly Gln Pro Tyr 
        195                 200                 205


Phe Ser Ile Asp Pro Lys Thr Gly Val Ile Arg Thr Ala Leu Pro Asn 
    210                 215                 220


Met Asp Arg Glu Val Lys Glu Gln Tyr Gln Val Leu Ile Gln Ala Lys 
225                 230                 235                 240


Asp Met Gly Gly Gln Leu Gly Gly Leu Ala Gly Thr Thr Ile Val Asn 
                245                 250                 255


Ile Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Arg Phe Pro Lys Ser 
            260                 265                 270


Ile Phe His Leu Lys Val Pro Glu Ser Ser Pro Ile Gly Ser Ala Ile 
        275                 280                 285


Gly Arg Ile Arg Ala Val Asp Pro Asp Phe Gly Gln Asn Ala Glu Ile 
    290                 295                 300


Glu Tyr Asn Ile Val Pro Gly Asp Gly Gly Asn Leu Phe Asp Ile Val 
305                 310                 315                 320


Thr Asp Glu Asp Thr Gln Glu Gly Val Ile Lys Leu Lys Lys Pro Leu 
                325                 330                 335


Asp Phe Glu Thr Lys Lys Ala Tyr Thr Phe Lys Val Glu Ala Ser Asn 
            340                 345                 350


Leu His Leu Asp His Arg Phe His Ser Ala Gly Pro Phe Lys Asp Thr 
        355                 360                 365


Ala Thr Val Lys Ile Ser Val Leu Asp Val Asp Glu Pro Pro Val Phe 
    370                 375                 380


Ser Lys Pro Leu Tyr Thr Met Glu Val Tyr Glu Asp Thr Pro Val Gly 
385                 390                 395                 400


Thr Ile Ile Gly Ala Val Thr Ala Gln Asp Leu Asp Val Gly Ser Ser 
                405                 410                 415


Ala Val Arg Tyr Phe Ile Asp Trp Lys Ser Asp Gly Asp Ser Tyr Phe 
            420                 425                 430


Thr Ile Asp Gly Asn Glu Gly Thr Ile Ala Thr Asn Glu Leu Leu Asp 
        435                 440                 445


Arg Glu Ser Thr Ala Gln Tyr Asn Phe Ser Ile Ile Ala Ser Lys Val 
    450                 455                 460


Ser Asn Pro Leu Leu Thr Ser Lys Val Asn Ile Leu Ile Asn Val Leu 
465                 470                 475                 480


Asp Val Asn Glu Phe Pro Pro Glu Ile Ser Val Pro Tyr Glu Thr Ala 
                485                 490                 495


Val Cys Glu Asn Ala Lys Pro Gly Gln Ile Ile Gln Ile Val Ser Ala 
            500                 505                 510


Ala Asp Arg Asp Leu Ser Pro Ala Gly Gln Gln Phe Ser Phe Arg Leu 
        515                 520                 525


Ser Pro Glu Ala Ala Ile Lys Pro Asn Phe Thr Val Arg Asp Phe Arg 
    530                 535                 540


Asn Asn Thr Ala Gly Ile Glu Thr Arg Arg Asn Gly Tyr Ser Arg Arg 
545                 550                 555                 560


Gln Gln Glu Leu Tyr Phe Leu Pro Val Val Ile Glu Asp Ser Ser Tyr 
                565                 570                 575


Pro Val Gln Ser Ser Thr Asn Thr Met Thr Ile Arg Val Cys Arg Cys 
            580                 585                 590


Asp Ser Asp Gly Thr Ile Leu Ser Cys Asn Val Glu Ala Ile Phe Leu 
        595                 600                 605


Pro Val Gly Leu Ser Thr Gly Ala Leu Ile Ala Ile Leu Leu Cys Ile 
    610                 615                 620


Val Ile Leu Leu Ala Ile Val Val Leu Tyr Val Ala Leu Arg Arg Gln 
625                 630                 635                 640


Lys Lys Lys Asp Thr Leu Met Thr Ser Lys Glu Asp Ile Arg Asp Asn 
                645                 650                 655


Val Ile His Tyr Asp Asp Glu Gly Gly Gly Glu Glu Asp Thr Gln Ala 
            660                 665                 670


Phe Asp Ile Gly Ala Leu Arg Asn Pro Lys Val Ile Glu Glu Asn Lys 
        675                 680                 685


Ile Arg Arg Asp Ile Lys Pro Asp Ser Leu Cys Leu Pro Arg Gln Arg 
    690                 695                 700


Pro Pro Met Glu Asp Asn Thr Asp Ile Arg Asp Phe Ile His Gln Arg 
705                 710                 715                 720


Leu Gln Glu Asn Asp Val Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu 
                725                 730                 735


Ala Thr Tyr Ala Tyr Glu Gly Ser Gly Ser Val Ala Glu Ser Leu Ser 
            740                 745                 750


Ser Ile Asp Ser Leu Thr Thr Glu Ala Asp Gln Asp Tyr Asp Tyr Leu 
        755                 760                 765


Thr Asp Trp Gly Pro Arg Phe Lys Val Leu Ala Asp Met Phe Gly Glu 
    770                 775                 780


Glu Glu Ser Tyr Asn Pro Asp Lys Val Thr 
785                 790


<210>  255
<211>  11659
<212>  DNA
<213>  Homo sapiens

<400>  255
gctggaggga tcctccattc ctgtgtcatt tgcatgggtc ctgctgtgaa atgaacctgg     60

cagggacttg ttagacactt ccttccttcc ctcattgagc actccagtgc cattgttcca    120

cagttgttct aattgggtcc tagcttcctc ctgccaaggc aaacagcata gtctcgagta    180

ggtgtcccta ggctcatctg ccagcctgaa catgaacaca ggcaaagctg atgatggcca    240

gggaccccag gggacgtggg gccctgtggg gtctggcccc caggagcaag acctctgatg    300

atgctggtgt ctgggagtga gcaccatgcc catcacccag gacaatgccg tgctgcacct    360

gcccctcctc taccagtggc tgcagaacag cctgcaggaa ggtggggatg ggccggagca    420

gcggctctgc caggcggcca tccagaagct gcaggagtac atccagctga actttgctgt    480

ggatgagagt acggtcccac ctgatcacag cccccccgaa atggagatct gtactgtgta    540

cctcaccaag gagctggggg acacagagac tgtgggcctg agttttggga acatccctgt    600

tttcggggac tatggtgaaa agcgcagggg gggcaagaag aggaaaaccc accagggtcc    660

tgtgctggat gtgggctgca tctgggtgac agagctgagg aagaacagcc cagcagggaa    720

gagtgggaag gtccgactgc gggatgagat cctctcactg aatgggcagc tgatggttgg    780

agttgatgtc agtggggcca gttacctggc tgagcagtgc tggaatggcg gctttatcta    840

cctgatcatg ctgcgtcgct ttaagcacaa agcccactcc acttataatg gcaacagtag    900

caacagctct gaaccaggag aaacacctac cttggagctg ggtgaccgaa ctgcgaaaaa    960

ggggaaacga accagaaagt ttggggtcat ctccaggcct cctgccaaca aggcccctga   1020

agaatccaag ggcagcgctg gctgtgaggt gtccagtgac cccagcactg agctggagaa   1080

cggccctgac cctgaacttg gaaacggcca tgtctttcag ctagaaaatg gcccagattc   1140

tctcaaggag gtggctggac cccatctaga gaggtcagaa gtggacagag ggacagagca   1200

tagaattcca aagacagatg ctcctctgac cacaagcaat gacaaacgcc gcttctcaaa   1260

aggtgggaag acggacttcc aatcgagtga ctgcctggca cgggaggaag ttggccgaat   1320

atggaagatg gagctgctca aagaatcgga tgggctggga attcaggtta gtggaggccg   1380

aggatcaaag cgctcacctc acgctatcgt tgtcactcaa gtgaaggaag gaggtgccgc   1440

tcacagggat ggcaggctgt ccttaggaga tgagctgctg gtaatcaatg gtcatttact   1500

ggtcgggctc tcccacgagg aagcagtggc cattcttcgc tccgccacgg gaatggtgca   1560

gcttgtggtg gccagcaagg aaaactccgc agaggacctc ctcaggttaa catctaagag   1620

cttgccagat ctgaccagct cggtagaaga tgtgtcctcc tggactgata acgaagacca   1680

ggaggcagac ggggaagagg acgaaggaac cagctcttct gtccagagag caatgcctgg   1740

gacagatgaa ccccaagatg tgtgcggtgc tgaggaatcc aaggggaact tggaaagtcc   1800

caaacagggc agcaataaaa tcaagctcaa gagtcgcctt tcagggggtg tacaccgcct   1860

tgagtcagtt gaagaatata acgagctgat ggtgcggaat ggggaccccc ggatccggat   1920

gttggaggtc tcccgagatg gccggaaaca ctccctcccg cagctgctgg actcttccag   1980

tgcctcacag gaataccaca ttgtgaagaa gtctacccgc tccttaagca cgactcaggt   2040

ggaatctcct tggaggctca ttcggccatc cgtcatctcg atcattgggt tgtacaaaga   2100

aaaaggcaag ggccttggct ttagtattgc tggaggtcga gactgcattc gtggacagat   2160

ggggattttt gtcaagacca tcttcccaaa tggatcagct gcagaggacg gaagacttaa   2220

agaaggggat gaaatcctag atgtaaatgg aataccaata aagggcttga catttcaaga   2280

agccattcat acctttaagc aaatccggag tggattattt gttttaacgg tacgcacaaa   2340

gttggtgagc cccagcctca caccctgctc gacacccaca cacatgagca gatccgcctc   2400

cccgaacttc aataccagtg ggggagcctc agcgggaggt tccgatgaag gcagttcttc   2460

atccctgggt cggaagaccc ctgggcccaa ggacaggatc gtcatggaag taacactcaa   2520

caaagagcca agagttggat taggcattgg tgcctgctgc ttggctctgg aaaacagtcc   2580

tcctggcatc tacattcaca gccttgctcc aggatcagtg gccaagatgg agagcaacct   2640

gagccgcggg gatcaaatcc tggaagtgaa ctccgtcaac gtccgccatg ctgctttaag   2700

caaagtccac gccatcttga gtaaatgccc tccaggaccc gttcgccttg tcatcggccg   2760

gcaccctaat ccaaaggttt ccgagcagga aatggatgaa gtcatagcac gcagcactta   2820

tcaggagagc aaagaggcca attcctctcc tggcttaggt acccccttga agagtccctc   2880

tcttgcaaaa aaggactccc ttatttctga atctgaactc tcccagtact ttgcccacga   2940

tgtccctggc cccttgtcag acttcatggt ggccggttct gaggacgagg atcacccggg   3000

aagtggctgc agcacgtcgg aggagggcag cctgcctccc agcacctcca ctcacaagga   3060

gcctggaaaa cccagagcca acagcctcgt gactcttggg agccatcggg cttctgggct   3120

cttccacaag caggtgacag ttgccagaca agccagtctc cccggaagcc cacaggccct   3180

ccgaaaccct ctcctccgcc agaggaaggt aggctgctac gatgccaacg atgccagtga   3240

tgaggaagag tttgacagag aaggggactg catttcactc ccaggggccc tcccgggtcc   3300

catcaggcct ctgtcagagg atgacccgag gcgtgtctca atttcctctt ccaagggcat   3360

ggacgtccac aaccaagagg aacgaccccg gaaaacactg gtgagcaagg ccatctcggc   3420

acctcttctt ggtagctcag tggacttaga ggagagtatc ccagagggca tggtggatgc   3480

tgcgtcctat gcagccaacc tcacggactc tgcagaggcc cccaagggga gccctggaag   3540

ctggtggaag aaggaactgt caggatcaag tagcgcaccc aaattggaat acacagtccg   3600

tacagacacc cagagtccga cgaacactgg gagccccagt tccccccagc agaaaagtga   3660

aggcctgggc tccaggcaca gaccagtggc cagggtaagc ccccactgca agagatccga   3720

ggctgaggcc aagcccagtg gctcacagac agtgaacctg actggcagag ccaatgatcc   3780

atgcgatctg gactcgagag tccaggccac ttctgtcaaa gtgactgtcg ctggctttca   3840

gccaggtgga gctgtggaga aggaatctct gggaaagctg accactggag atgcttgtgt   3900

ctctaccagc tgtgaactag ccagtgctct gtcccatctg gatgccagcc acctcacaga   3960

gaacctgccc aaagctgcat cagagctggg gcaacaaccc atgactgaac tggacagctc   4020

ctcagacctc atctcttccc cagggaagaa gggggccgct catcctgacc ccagcaagac   4080

ctctgtagac acagggcaag tcagtcggcc agagaatccc agccagcctg catcgcccag   4140

ggtcaccaag tgcaaggcca ggtctccagt caggctcccc catgagggca gcccctcccc   4200

gggggagaaa gcagcggctc cccctgacta cagcaagact cgatcagcat cggaaaccag   4260

cacaccccac aataccagga gggtggctgc cctcagggga gcgggacctg gagcagaggg   4320

aatgacacca gctggtgctg tcctgccagg agaccccctc acatcccagg agcagagaca   4380

gggagctcca ggtaaccaca gtaaggctct ggaaatgaca ggaatccatg cacctgaaag   4440

ctcccaggag ccttccctgc tggagggagc agattctgtg tcctcaaggg caccgcaggc   4500

cagcctctcc atgctgccat ccactgacaa caccaaagaa gcatgtggcc atgtctcggg   4560

gcactgctgc ccagggggga gtagagagag ccctgtgacg gacattgaca gcttcatcaa   4620

ggagctggat gcttctgcag caaggtctcc gtcttcccag acgggggaca gtggctctca   4680

ggagggcagt gctcagggcc acccaccagc cggggctgga ggtgggagct cctgccgtgc   4740

cgaaccagtc ccggggggcc agacctcctc cccgaggagg gcctgggctg ctggtgcccc   4800

cgcctaccca caatgggcct cccagccttc ggttttagat tcaattaatc ccgacaaaca   4860

ttttactgtg aacaaaaact ttctgagcaa ctactctaga aattttagca gttttcatga   4920

agacagcacc tccctatcag gcctgggtga cagcacggag ccgtctctgt catccatgta   4980

tggcgatgct gaggattctt cttctgaccc tgagtcactc actgaagccc cacgagcttc   5040

tgccagggac ggctggtccc ctcctcgttc ccgtgtgtct ttgcacaagg aagatccttc   5100

ggagtcagaa gaggaacaga ttgagatttg ttccacacgt ggctgcccca atccaccctc   5160

gagtcctgct catcttccca cccaggctgc catctgtcct gcctcagcca aagttctgtc   5220

attaaaatac agcactccga gagagtcggt ggccagtccc cgtgagaagg ccgcctgctt   5280

gccaggctca tacacttcag gcccagactc ttcccagcca tcatcactct tggagatgag   5340

ctctcaggag catgaaactc atgcggacat aagcacttca cagaaccaca ggccctcgtg   5400

tgcagaagaa accacagaag tcaccagcgc tagctcagcc atggaaaaca gtccgctgtc   5460

taaagtagcc aggcattttc acagtccgcc catcattctc agctccccca acatggtaaa   5520

tggcttggaa catgacctgc tagatgacga aaccctgaat caatacgaaa caagcattaa   5580

tgcagctgcc agtctgtcct ccttcagtgt ggatgtccct aagaatggag aatctgtttt   5640

ggaaaacctc cacatctctg aaagtcaaga cctggatgac ttgctacaga aaccaaaaat   5700

gatcgctagg aggcccatca tggcctggtt taaagaaata aataaacata accaaggcac   5760

acatttgagg agcaaaaccg agaaggaaca acctctaatg cctgccagaa gtcccgactc   5820

caagattcag atggtgagtt caagccaaaa aaagggcgtt actgtgcctc atagccctcc   5880

tcagccgaaa acaaacctgg aaaataagga cctgtctaag aagagtccgg cagaaatgct   5940

tctgactaat ggtcagaagg caaagtgtgg tccgaagctg aagaggctca gcctcaaggg   6000

caaggccaaa gtcaactctg aggcccctgc tgcgaatgct gtgaaggctg gggggacgga   6060

ccacaggaaa cccttgatct caccccagac ctcccacaaa acactttcta aggcagtgtc   6120

acagcggctc catgtagccg accacgagga ccctgacaga aacaccacag ctgcccccag   6180

gtccccccag tgtgtgctgg aaagcaagcc acctcttgcc acctctgggc cactgaaacc   6240

ctcagtgtct gacacgagca tcaggacatt tgtctcgccc ctgacctctc ccaagcctgt   6300

tcctgagcaa ggcatgtgga gcaggttcca catggctgtc ctctctgaac ccgacagagg   6360

ttgcccaacc acccctaaat ctcctaagtg tagagcagag ggcagggcgc cccgtgctga   6420

ctccgggccg gtgagtccgg cagcgtctag gaacggcatg tccgtggcag ggaacagaca   6480

gagtgagccg cgcctggcca gccatgtggc agcagacaca gcccaaccca ggccgactgg   6540

cgaaaaagga ggcaacataa tggccagcga tcgcctcgaa agaacaaacc agctgaaaat   6600

cgtggagatt tctgctgaag cagtgtcaga gactgtatgt ggtaacaagc cagctgaaag   6660

cgacagacgg ggagggtgct tggcccaggg caactgtcag gagaagagtg aaatcaggct   6720

ctatcgccag gtcgcagaat catccacaag tcatccatcc tcactcccat ctcatgcctc   6780

ccaggcagag caggaaatgt cacgatcatt cagcatggca aaactggcgt cctcctcctc   6840

ctcccttcaa acagccatta gaaaggcaga atactcccag ggaaaatcaa gcctgatgtc   6900

agactcccga ggggtgccca gaaacagcat tccagggggc ccctcggggg aggaccatct   6960

ctacttcacc ccaaggccag cgaccaggac ctactccatg ccagcccagt tctcaagcca   7020

ttttggacgg gagggtcacc ccccacacag cctgggtcgc tctcgggaca gccaggtccc   7080

tgtgacaagc agtgttgtcc ccgaggcaaa ggcatccaga ggtggtcttc ccagcctggc   7140

taatggacag ggcatatata gtgtaaagcc gctgctggac acatcgagga atcttccagc   7200

cacagatgaa ggggatatca tttcagtcca ggagacgagc tgcctagtca cagacaaaat   7260

caaagtcacc agacgacact actgctatga gcagaactgg ccccatgaat ctacctcatt   7320

tttctctgtg aagcagcgga tcaagtcttt tgagaacctg gccaatgctg accggcctgt   7380

agccaagtcc ggggcttccc catttttgtc ggtgagctcc aagcctccca ttgggaggcg   7440

gtcttccggc agcattgttt ccgggagcct gggccaccca ggtgacgcag cagcaaggtt   7500

gttgagacgc agcttgagtt cctgcagcga aaaccaaagc gaagccggca ccctcctgcc   7560

ccagatggcc aagtctccct caatcatgac actgaccatc tctcggcaga acccaccaga   7620

gaccagtagc aagggctctg attcggaact aaagaaatca cttggtcctt tgggaattcc   7680

caccccaacg atgaccctgg cttctcctgt taagaggaac aagtcctcgg tacgccacac   7740

gcagccctcg cccgtgtccc gctccaagct ccaggagctg agagccttga gcatgcctga   7800

ccttgacaag ctctgcagcg aggattactc agcagggccg agcgccgtgc tcttcaaaac   7860

tgagctggag atcaccccca ggaggtcacc tggccctcct gctggaggcg tttcgtgtcc   7920

cgagaagggc gggaacaggg cctgtccagg aggaagtggc cctaaaacca gtgctgctga   7980

gacacccagt tcagccagtg atacgggtga agctgcccag gatctgcctt ttagaagaag   8040

ctggtcagtt aatttggatc aacttctagt ctcagcgggg gaccagcaaa gattacagtc   8100

tgttttatcg tcagtgggat cgaaatctac catcctaact ctcattcagg aagcgaaagc   8160

acaatcagag aatgaagaag atgtttgctt catagtcttg aatagaaaag aaggctcagg   8220

tctgggattc agtgtggcag gagggacaga tgtggagcca aaatcaatca cggtccacag   8280

ggtgttttct cagggggcgg cttctcagga agggactatg aaccgagggg atttccttct   8340

gtcagtcaac ggcgcctcac tggctggctt agcccacggg aatgtcctga aggttctgca   8400

ccaggcacag ctgcacaaag atgccctcgt ggtcatcaag aaagggatgg atcagcccag   8460

gccctctgcc cggcaggagc ctcccacagc caatgggaag ggtttgctgt ccagaaagac   8520

catccccctg gagcctggca ttgggagaag tgtggctgta cacgatgctc tgtgtgttga   8580

agtgctgaag acctcggctg ggctgggact gagtctggat gggggaaaat catcggtgac   8640

gggagatggg cccttggtca ttaaaagagt gtacaaaggt ggtgcggctg aacaagctgg   8700

aataatagaa gctggagatg aaattcttgc tattaatggg aaacctctgg ttgggctcat   8760

gcactttgat gcctggaata ttatgaagtc tgtcccagaa ggacctgtgc agttattaat   8820

tagaaagcat aggaattctt catgaatttt aacaagaatc attttctcag ttctcttctt   8880

tctttagcaa atcagagtga cttctttaaa ccacaggttg ttgaaatggc caacactggt   8940

acagacacgg actataaaaa tctccaagct tgtgcttaca catgaagcct gacttaactg   9000

tatgtgcaac agcaatgaaa ttaactccag aagccttcca cctgcgtcac ccaggccggg   9060

agggttcctt cgttccagtg cctgtcccct acctttatgt tatgtttact gatggggata   9120

caagatgtga cacacccttc tttatttgaa acaaacaaac atttagctag acctttgctt   9180

ccttcttgcc agctctccca acatacccaa tcctggtgat cagggaacta aaagtctgag   9240

ggggacacaa atgtcacacc taagaggaca atcaatcatt ttgtatgatt ttgtaagtaa   9300

atgacagaat gcttttaggc acattcaatg gaaggaggag atgtaggtct gtatatgtta   9360

ccctgaaaag agaataagac ttacttaaaa aaatgaatta tgacctgtta ggctgagctc   9420

aggaattgtc caaaaaggaa aaagcaaaat aattaattga gagtattttt tagtgagtgt   9480

aatgtataat gtacgtatgc aaagttcaac tcaataggtt attgatcacc atgaagtatt   9540

gatcattttc tatctcaaaa gtgtaagcca taaggctgtt ttacagaata gcacttctga   9600

taagctgtat taaatagcca tgagcttcac tgcttagagg gagcagaaag gtcaacatct   9660

aaaagcacct tacaactagt ttttgaacct gtcttgataa gtgcttgaat tcaagactgg   9720

tcagtccaag agcagacaaa aatatcacaa gtcagtcagt cactgggttt ccatttctga   9780

attttatgca ctccaaccat gaatttaaac taaattttta gaaatcaagt atctttctaa   9840

gtgtccttgg atttatagac aatgtatgta caatccaaat agaggagctt aatggaatcc   9900

ttttaggaga ctggttggtt tttttccctc tttcccaaca tgtttaagaa atgtaacatt   9960

ctaagtattg gatctctttt cttgacctag tataatgaca actgcagtga cttaagtttt  10020

tgctgttttc gttttcccgc tttgcaattt cctccttttg ccaaaaatgt tttcctacag  10080

aagactgtcg tgactcacgc tacttgggaa actcactctg gccactcctc ctctggtggc  10140

atgagctgct tcccagtagc tattccgatt ggatattccg ttcgtcgtca catagctggc  10200

ttttctctcc tcatgatgta ccttattttc ttaggtaaat aattccaaac tctcatcggg  10260

tcataaagag gaggagaaac agggtgagtc aaggtaaagg agcagaaatg tagttacaag  10320

ccaggtcgtc ttcagtggca caaaccaacc cgttgagccc tgacaacatg agtggagagt  10380

gcatttgcca tacctgtgtg catgacacta agattttatg ttggagatac ttctttaaat  10440

aacctacagc ttgggtctat ggctgtgacc cccagattca tggaggggct ttagccatca  10500

gctttgtaca tcatcatttt tctgaatgac caatcccact aaacatcttt gaagtcggcc  10560

tagagaggtc cttcagatga gagagaaata gctggcttgt ctgagtccag atttctcatc  10620

aactggcaat acaaaggaaa atatggtaca ggagttagtt agaaaggtct tattgatttt  10680

acttctactt ttcactacag ttacaggtag aatactgtag gaagtcagtg caaggtgcat  10740

gcttgattga tagatattga ttgattgttt ttcagtctct ggggtcagtt ttgtggtttc  10800

tgctttcttg cctaaatcaa agactatttc aagtcaacaa cactgaaaac tgcttttcgc  10860

ctccactctt acagctgtgc ctaataataa ttaattaata aacgcacagc cctatgtgaa  10920

cagacaggaa tttcttgtgc aatgtggagc aaatggaatg gtctccttcc gcaagtcttt  10980

ttaatcctca tatctggagt acaagggtag acctctggct taccacatac actatgctaa  11040

agtcatcagc cactgctact acatcttgcc agaaggtttc cctcgccaac aaacagttga  11100

aatttaaggg aagaagcaaa agctaaactg tctttgaccc taagatagat agaaagctat  11160

ttatttgtct tcagtgttca aggcatgact agtatttcta attagcctaa taaattccca  11220

cactttctga agtgaacact aatggtattg tcctactaaa actgtcattg tttctttttt  11280

tttaactggt cagtcattca caataagcta tgagggtaaa taaatatgtg ttataacaag  11340

taaaccgtag ttgcaagaat ataccatgaa gattaaagta ggctgggttt catttccatc  11400

ttcccacaca tctcattgaa tttgatggtt gacttaattg gcaccataac tttgtatgat  11460

attatacatt aacctttatt tatgtaaagt aaaatgcctt atatattaaa gagtaagtgc  11520

aataatatga aatagcctgt acattttaaa aatgttgtca ccaagttata taaatccaca  11580

tctctgtaaa caaccttttt taagtaattt taaaaaaaat aaacactctg cttactactt  11640

gaaaaaaaaa aaaaaaaaa                                               11659


<210>  256
<211>  2839
<212>  PRT
<213>  Homo sapiens

<400>  256

Met Pro Ile Thr Gln Asp Asn Ala Val Leu His Leu Pro Leu Leu Tyr 
1               5                   10                  15


Gln Trp Leu Gln Asn Ser Leu Gln Glu Gly Gly Asp Gly Pro Glu Gln 
            20                  25                  30


Arg Leu Cys Gln Ala Ala Ile Gln Lys Leu Gln Glu Tyr Ile Gln Leu 
        35                  40                  45


Asn Phe Ala Val Asp Glu Ser Thr Val Pro Pro Asp His Ser Pro Pro 
    50                  55                  60


Glu Met Glu Ile Cys Thr Val Tyr Leu Thr Lys Glu Leu Gly Asp Thr 
65                  70                  75                  80


Glu Thr Val Gly Leu Ser Phe Gly Asn Ile Pro Val Phe Gly Asp Tyr 
                85                  90                  95


Gly Glu Lys Arg Arg Gly Gly Lys Lys Arg Lys Thr His Gln Gly Pro 
            100                 105                 110


Val Leu Asp Val Gly Cys Ile Trp Val Thr Glu Leu Arg Lys Asn Ser 
        115                 120                 125


Pro Ala Gly Lys Ser Gly Lys Val Arg Leu Arg Asp Glu Ile Leu Ser 
    130                 135                 140


Leu Asn Gly Gln Leu Met Val Gly Val Asp Val Ser Gly Ala Ser Tyr 
145                 150                 155                 160


Leu Ala Glu Gln Cys Trp Asn Gly Gly Phe Ile Tyr Leu Ile Met Leu 
                165                 170                 175


Arg Arg Phe Lys His Lys Ala His Ser Thr Tyr Asn Gly Asn Ser Ser 
            180                 185                 190


Asn Ser Ser Glu Pro Gly Glu Thr Pro Thr Leu Glu Leu Gly Asp Arg 
        195                 200                 205


Thr Ala Lys Lys Gly Lys Arg Thr Arg Lys Phe Gly Val Ile Ser Arg 
    210                 215                 220


Pro Pro Ala Asn Lys Ala Pro Glu Glu Ser Lys Gly Ser Ala Gly Cys 
225                 230                 235                 240


Glu Val Ser Ser Asp Pro Ser Thr Glu Leu Glu Asn Gly Pro Asp Pro 
                245                 250                 255


Glu Leu Gly Asn Gly His Val Phe Gln Leu Glu Asn Gly Pro Asp Ser 
            260                 265                 270


Leu Lys Glu Val Ala Gly Pro His Leu Glu Arg Ser Glu Val Asp Arg 
        275                 280                 285


Gly Thr Glu His Arg Ile Pro Lys Thr Asp Ala Pro Leu Thr Thr Ser 
    290                 295                 300


Asn Asp Lys Arg Arg Phe Ser Lys Gly Gly Lys Thr Asp Phe Gln Ser 
305                 310                 315                 320


Ser Asp Cys Leu Ala Arg Glu Glu Val Gly Arg Ile Trp Lys Met Glu 
                325                 330                 335


Leu Leu Lys Glu Ser Asp Gly Leu Gly Ile Gln Val Ser Gly Gly Arg 
            340                 345                 350


Gly Ser Lys Arg Ser Pro His Ala Ile Val Val Thr Gln Val Lys Glu 
        355                 360                 365


Gly Gly Ala Ala His Arg Asp Gly Arg Leu Ser Leu Gly Asp Glu Leu 
    370                 375                 380


Leu Val Ile Asn Gly His Leu Leu Val Gly Leu Ser His Glu Glu Ala 
385                 390                 395                 400


Val Ala Ile Leu Arg Ser Ala Thr Gly Met Val Gln Leu Val Val Ala 
                405                 410                 415


Ser Lys Glu Asn Ser Ala Glu Asp Leu Leu Arg Leu Thr Ser Lys Ser 
            420                 425                 430


Leu Pro Asp Leu Thr Ser Ser Val Glu Asp Val Ser Ser Trp Thr Asp 
        435                 440                 445


Asn Glu Asp Gln Glu Ala Asp Gly Glu Glu Asp Glu Gly Thr Ser Ser 
    450                 455                 460


Ser Val Gln Arg Ala Met Pro Gly Thr Asp Glu Pro Gln Asp Val Cys 
465                 470                 475                 480


Gly Ala Glu Glu Ser Lys Gly Asn Leu Glu Ser Pro Lys Gln Gly Ser 
                485                 490                 495


Asn Lys Ile Lys Leu Lys Ser Arg Leu Ser Gly Gly Val His Arg Leu 
            500                 505                 510


Glu Ser Val Glu Glu Tyr Asn Glu Leu Met Val Arg Asn Gly Asp Pro 
        515                 520                 525


Arg Ile Arg Met Leu Glu Val Ser Arg Asp Gly Arg Lys His Ser Leu 
    530                 535                 540


Pro Gln Leu Leu Asp Ser Ser Ser Ala Ser Gln Glu Tyr His Ile Val 
545                 550                 555                 560


Lys Lys Ser Thr Arg Ser Leu Ser Thr Thr Gln Val Glu Ser Pro Trp 
                565                 570                 575


Arg Leu Ile Arg Pro Ser Val Ile Ser Ile Ile Gly Leu Tyr Lys Glu 
            580                 585                 590


Lys Gly Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly Arg Asp Cys Ile 
        595                 600                 605


Arg Gly Gln Met Gly Ile Phe Val Lys Thr Ile Phe Pro Asn Gly Ser 
    610                 615                 620


Ala Ala Glu Asp Gly Arg Leu Lys Glu Gly Asp Glu Ile Leu Asp Val 
625                 630                 635                 640


Asn Gly Ile Pro Ile Lys Gly Leu Thr Phe Gln Glu Ala Ile His Thr 
                645                 650                 655


Phe Lys Gln Ile Arg Ser Gly Leu Phe Val Leu Thr Val Arg Thr Lys 
            660                 665                 670


Leu Val Ser Pro Ser Leu Thr Pro Cys Ser Thr Pro Thr His Met Ser 
        675                 680                 685


Arg Ser Ala Ser Pro Asn Phe Asn Thr Ser Gly Gly Ala Ser Ala Gly 
    690                 695                 700


Gly Ser Asp Glu Gly Ser Ser Ser Ser Leu Gly Arg Lys Thr Pro Gly 
705                 710                 715                 720


Pro Lys Asp Arg Ile Val Met Glu Val Thr Leu Asn Lys Glu Pro Arg 
                725                 730                 735


Val Gly Leu Gly Ile Gly Ala Cys Cys Leu Ala Leu Glu Asn Ser Pro 
            740                 745                 750


Pro Gly Ile Tyr Ile His Ser Leu Ala Pro Gly Ser Val Ala Lys Met 
        755                 760                 765


Glu Ser Asn Leu Ser Arg Gly Asp Gln Ile Leu Glu Val Asn Ser Val 
    770                 775                 780


Asn Val Arg His Ala Ala Leu Ser Lys Val His Ala Ile Leu Ser Lys 
785                 790                 795                 800


Cys Pro Pro Gly Pro Val Arg Leu Val Ile Gly Arg His Pro Asn Pro 
                805                 810                 815


Lys Val Ser Glu Gln Glu Met Asp Glu Val Ile Ala Arg Ser Thr Tyr 
            820                 825                 830


Gln Glu Ser Lys Glu Ala Asn Ser Ser Pro Gly Leu Gly Thr Pro Leu 
        835                 840                 845


Lys Ser Pro Ser Leu Ala Lys Lys Asp Ser Leu Ile Ser Glu Ser Glu 
    850                 855                 860


Leu Ser Gln Tyr Phe Ala His Asp Val Pro Gly Pro Leu Ser Asp Phe 
865                 870                 875                 880


Met Val Ala Gly Ser Glu Asp Glu Asp His Pro Gly Ser Gly Cys Ser 
                885                 890                 895


Thr Ser Glu Glu Gly Ser Leu Pro Pro Ser Thr Ser Thr His Lys Glu 
            900                 905                 910


Pro Gly Lys Pro Arg Ala Asn Ser Leu Val Thr Leu Gly Ser His Arg 
        915                 920                 925


Ala Ser Gly Leu Phe His Lys Gln Val Thr Val Ala Arg Gln Ala Ser 
    930                 935                 940


Leu Pro Gly Ser Pro Gln Ala Leu Arg Asn Pro Leu Leu Arg Gln Arg 
945                 950                 955                 960


Lys Val Gly Cys Tyr Asp Ala Asn Asp Ala Ser Asp Glu Glu Glu Phe 
                965                 970                 975


Asp Arg Glu Gly Asp Cys Ile Ser Leu Pro Gly Ala Leu Pro Gly Pro 
            980                 985                 990


Ile Arg Pro Leu Ser Glu Asp Asp Pro Arg Arg Val Ser Ile Ser Ser 
        995                 1000                1005


Ser Lys Gly Met Asp Val His Asn Gln Glu Glu Arg Pro Arg Lys Thr 
    1010                1015                1020


Leu Val Ser Lys Ala Ile Ser Ala Pro Leu Leu Gly Ser Ser Val Asp 
1025                1030                1035                1040


Leu Glu Glu Ser Ile Pro Glu Gly Met Val Asp Ala Ala Ser Tyr Ala 
                1045                1050                1055


Ala Asn Leu Thr Asp Ser Ala Glu Ala Pro Lys Gly Ser Pro Gly Ser 
            1060                1065                1070


Trp Trp Lys Lys Glu Leu Ser Gly Ser Ser Ser Ala Pro Lys Leu Glu 
        1075                1080                1085


Tyr Thr Val Arg Thr Asp Thr Gln Ser Pro Thr Asn Thr Gly Ser Pro 
    1090                1095                1100


Ser Ser Pro Gln Gln Lys Ser Glu Gly Leu Gly Ser Arg His Arg Pro 
1105                1110                1115                1120


Val Ala Arg Val Ser Pro His Cys Lys Arg Ser Glu Ala Glu Ala Lys 
                1125                1130                1135


Pro Ser Gly Ser Gln Thr Val Asn Leu Thr Gly Arg Ala Asn Asp Pro 
            1140                1145                1150


Cys Asp Leu Asp Ser Arg Val Gln Ala Thr Ser Val Lys Val Thr Val 
        1155                1160                1165


Ala Gly Phe Gln Pro Gly Gly Ala Val Glu Lys Glu Ser Leu Gly Lys 
    1170                1175                1180


Leu Thr Thr Gly Asp Ala Cys Val Ser Thr Ser Cys Glu Leu Ala Ser 
1185                1190                1195                1200


Ala Leu Ser His Leu Asp Ala Ser His Leu Thr Glu Asn Leu Pro Lys 
                1205                1210                1215


Ala Ala Ser Glu Leu Gly Gln Gln Pro Met Thr Glu Leu Asp Ser Ser 
            1220                1225                1230


Ser Asp Leu Ile Ser Ser Pro Gly Lys Lys Gly Ala Ala His Pro Asp 
        1235                1240                1245


Pro Ser Lys Thr Ser Val Asp Thr Gly Gln Val Ser Arg Pro Glu Asn 
    1250                1255                1260


Pro Ser Gln Pro Ala Ser Pro Arg Val Thr Lys Cys Lys Ala Arg Ser 
1265                1270                1275                1280


Pro Val Arg Leu Pro His Glu Gly Ser Pro Ser Pro Gly Glu Lys Ala 
                1285                1290                1295


Ala Ala Pro Pro Asp Tyr Ser Lys Thr Arg Ser Ala Ser Glu Thr Ser 
            1300                1305                1310


Thr Pro His Asn Thr Arg Arg Val Ala Ala Leu Arg Gly Ala Gly Pro 
        1315                1320                1325


Gly Ala Glu Gly Met Thr Pro Ala Gly Ala Val Leu Pro Gly Asp Pro 
    1330                1335                1340


Leu Thr Ser Gln Glu Gln Arg Gln Gly Ala Pro Gly Asn His Ser Lys 
1345                1350                1355                1360


Ala Leu Glu Met Thr Gly Ile His Ala Pro Glu Ser Ser Gln Glu Pro 
                1365                1370                1375


Ser Leu Leu Glu Gly Ala Asp Ser Val Ser Ser Arg Ala Pro Gln Ala 
            1380                1385                1390


Ser Leu Ser Met Leu Pro Ser Thr Asp Asn Thr Lys Glu Ala Cys Gly 
        1395                1400                1405


His Val Ser Gly His Cys Cys Pro Gly Gly Ser Arg Glu Ser Pro Val 
    1410                1415                1420


Thr Asp Ile Asp Ser Phe Ile Lys Glu Leu Asp Ala Ser Ala Ala Arg 
1425                1430                1435                1440


Ser Pro Ser Ser Gln Thr Gly Asp Ser Gly Ser Gln Glu Gly Ser Ala 
                1445                1450                1455


Gln Gly His Pro Pro Ala Gly Ala Gly Gly Gly Ser Ser Cys Arg Ala 
            1460                1465                1470


Glu Pro Val Pro Gly Gly Gln Thr Ser Ser Pro Arg Arg Ala Trp Ala 
        1475                1480                1485


Ala Gly Ala Pro Ala Tyr Pro Gln Trp Ala Ser Gln Pro Ser Val Leu 
    1490                1495                1500


Asp Ser Ile Asn Pro Asp Lys His Phe Thr Val Asn Lys Asn Phe Leu 
1505                1510                1515                1520


Ser Asn Tyr Ser Arg Asn Phe Ser Ser Phe His Glu Asp Ser Thr Ser 
                1525                1530                1535


Leu Ser Gly Leu Gly Asp Ser Thr Glu Pro Ser Leu Ser Ser Met Tyr 
            1540                1545                1550


Gly Asp Ala Glu Asp Ser Ser Ser Asp Pro Glu Ser Leu Thr Glu Ala 
        1555                1560                1565


Pro Arg Ala Ser Ala Arg Asp Gly Trp Ser Pro Pro Arg Ser Arg Val 
    1570                1575                1580


Ser Leu His Lys Glu Asp Pro Ser Glu Ser Glu Glu Glu Gln Ile Glu 
1585                1590                1595                1600


Ile Cys Ser Thr Arg Gly Cys Pro Asn Pro Pro Ser Ser Pro Ala His 
                1605                1610                1615


Leu Pro Thr Gln Ala Ala Ile Cys Pro Ala Ser Ala Lys Val Leu Ser 
            1620                1625                1630


Leu Lys Tyr Ser Thr Pro Arg Glu Ser Val Ala Ser Pro Arg Glu Lys 
        1635                1640                1645


Ala Ala Cys Leu Pro Gly Ser Tyr Thr Ser Gly Pro Asp Ser Ser Gln 
    1650                1655                1660


Pro Ser Ser Leu Leu Glu Met Ser Ser Gln Glu His Glu Thr His Ala 
1665                1670                1675                1680


Asp Ile Ser Thr Ser Gln Asn His Arg Pro Ser Cys Ala Glu Glu Thr 
                1685                1690                1695


Thr Glu Val Thr Ser Ala Ser Ser Ala Met Glu Asn Ser Pro Leu Ser 
            1700                1705                1710


Lys Val Ala Arg His Phe His Ser Pro Pro Ile Ile Leu Ser Ser Pro 
        1715                1720                1725


Asn Met Val Asn Gly Leu Glu His Asp Leu Leu Asp Asp Glu Thr Leu 
    1730                1735                1740


Asn Gln Tyr Glu Thr Ser Ile Asn Ala Ala Ala Ser Leu Ser Ser Phe 
1745                1750                1755                1760


Ser Val Asp Val Pro Lys Asn Gly Glu Ser Val Leu Glu Asn Leu His 
                1765                1770                1775


Ile Ser Glu Ser Gln Asp Leu Asp Asp Leu Leu Gln Lys Pro Lys Met 
            1780                1785                1790


Ile Ala Arg Arg Pro Ile Met Ala Trp Phe Lys Glu Ile Asn Lys His 
        1795                1800                1805


Asn Gln Gly Thr His Leu Arg Ser Lys Thr Glu Lys Glu Gln Pro Leu 
    1810                1815                1820


Met Pro Ala Arg Ser Pro Asp Ser Lys Ile Gln Met Val Ser Ser Ser 
1825                1830                1835                1840


Gln Lys Lys Gly Val Thr Val Pro His Ser Pro Pro Gln Pro Lys Thr 
                1845                1850                1855


Asn Leu Glu Asn Lys Asp Leu Ser Lys Lys Ser Pro Ala Glu Met Leu 
            1860                1865                1870


Leu Thr Asn Gly Gln Lys Ala Lys Cys Gly Pro Lys Leu Lys Arg Leu 
        1875                1880                1885


Ser Leu Lys Gly Lys Ala Lys Val Asn Ser Glu Ala Pro Ala Ala Asn 
    1890                1895                1900


Ala Val Lys Ala Gly Gly Thr Asp His Arg Lys Pro Leu Ile Ser Pro 
1905                1910                1915                1920


Gln Thr Ser His Lys Thr Leu Ser Lys Ala Val Ser Gln Arg Leu His 
                1925                1930                1935


Val Ala Asp His Glu Asp Pro Asp Arg Asn Thr Thr Ala Ala Pro Arg 
            1940                1945                1950


Ser Pro Gln Cys Val Leu Glu Ser Lys Pro Pro Leu Ala Thr Ser Gly 
        1955                1960                1965


Pro Leu Lys Pro Ser Val Ser Asp Thr Ser Ile Arg Thr Phe Val Ser 
    1970                1975                1980


Pro Leu Thr Ser Pro Lys Pro Val Pro Glu Gln Gly Met Trp Ser Arg 
1985                1990                1995                2000


Phe His Met Ala Val Leu Ser Glu Pro Asp Arg Gly Cys Pro Thr Thr 
                2005                2010                2015


Pro Lys Ser Pro Lys Cys Arg Ala Glu Gly Arg Ala Pro Arg Ala Asp 
            2020                2025                2030


Ser Gly Pro Val Ser Pro Ala Ala Ser Arg Asn Gly Met Ser Val Ala 
        2035                2040                2045


Gly Asn Arg Gln Ser Glu Pro Arg Leu Ala Ser His Val Ala Ala Asp 
    2050                2055                2060


Thr Ala Gln Pro Arg Pro Thr Gly Glu Lys Gly Gly Asn Ile Met Ala 
2065                2070                2075                2080


Ser Asp Arg Leu Glu Arg Thr Asn Gln Leu Lys Ile Val Glu Ile Ser 
                2085                2090                2095


Ala Glu Ala Val Ser Glu Thr Val Cys Gly Asn Lys Pro Ala Glu Ser 
            2100                2105                2110


Asp Arg Arg Gly Gly Cys Leu Ala Gln Gly Asn Cys Gln Glu Lys Ser 
        2115                2120                2125


Glu Ile Arg Leu Tyr Arg Gln Val Ala Glu Ser Ser Thr Ser His Pro 
    2130                2135                2140


Ser Ser Leu Pro Ser His Ala Ser Gln Ala Glu Gln Glu Met Ser Arg 
2145                2150                2155                2160


Ser Phe Ser Met Ala Lys Leu Ala Ser Ser Ser Ser Ser Leu Gln Thr 
                2165                2170                2175


Ala Ile Arg Lys Ala Glu Tyr Ser Gln Gly Lys Ser Ser Leu Met Ser 
            2180                2185                2190


Asp Ser Arg Gly Val Pro Arg Asn Ser Ile Pro Gly Gly Pro Ser Gly 
        2195                2200                2205


Glu Asp His Leu Tyr Phe Thr Pro Arg Pro Ala Thr Arg Thr Tyr Ser 
    2210                2215                2220


Met Pro Ala Gln Phe Ser Ser His Phe Gly Arg Glu Gly His Pro Pro 
2225                2230                2235                2240


His Ser Leu Gly Arg Ser Arg Asp Ser Gln Val Pro Val Thr Ser Ser 
                2245                2250                2255


Val Val Pro Glu Ala Lys Ala Ser Arg Gly Gly Leu Pro Ser Leu Ala 
            2260                2265                2270


Asn Gly Gln Gly Ile Tyr Ser Val Lys Pro Leu Leu Asp Thr Ser Arg 
        2275                2280                2285


Asn Leu Pro Ala Thr Asp Glu Gly Asp Ile Ile Ser Val Gln Glu Thr 
    2290                2295                2300


Ser Cys Leu Val Thr Asp Lys Ile Lys Val Thr Arg Arg His Tyr Cys 
2305                2310                2315                2320


Tyr Glu Gln Asn Trp Pro His Glu Ser Thr Ser Phe Phe Ser Val Lys 
                2325                2330                2335


Gln Arg Ile Lys Ser Phe Glu Asn Leu Ala Asn Ala Asp Arg Pro Val 
            2340                2345                2350


Ala Lys Ser Gly Ala Ser Pro Phe Leu Ser Val Ser Ser Lys Pro Pro 
        2355                2360                2365


Ile Gly Arg Arg Ser Ser Gly Ser Ile Val Ser Gly Ser Leu Gly His 
    2370                2375                2380


Pro Gly Asp Ala Ala Ala Arg Leu Leu Arg Arg Ser Leu Ser Ser Cys 
2385                2390                2395                2400


Ser Glu Asn Gln Ser Glu Ala Gly Thr Leu Leu Pro Gln Met Ala Lys 
                2405                2410                2415


Ser Pro Ser Ile Met Thr Leu Thr Ile Ser Arg Gln Asn Pro Pro Glu 
            2420                2425                2430


Thr Ser Ser Lys Gly Ser Asp Ser Glu Leu Lys Lys Ser Leu Gly Pro 
        2435                2440                2445


Leu Gly Ile Pro Thr Pro Thr Met Thr Leu Ala Ser Pro Val Lys Arg 
    2450                2455                2460


Asn Lys Ser Ser Val Arg His Thr Gln Pro Ser Pro Val Ser Arg Ser 
2465                2470                2475                2480


Lys Leu Gln Glu Leu Arg Ala Leu Ser Met Pro Asp Leu Asp Lys Leu 
                2485                2490                2495


Cys Ser Glu Asp Tyr Ser Ala Gly Pro Ser Ala Val Leu Phe Lys Thr 
            2500                2505                2510


Glu Leu Glu Ile Thr Pro Arg Arg Ser Pro Gly Pro Pro Ala Gly Gly 
        2515                2520                2525


Val Ser Cys Pro Glu Lys Gly Gly Asn Arg Ala Cys Pro Gly Gly Ser 
    2530                2535                2540


Gly Pro Lys Thr Ser Ala Ala Glu Thr Pro Ser Ser Ala Ser Asp Thr 
2545                2550                2555                2560


Gly Glu Ala Ala Gln Asp Leu Pro Phe Arg Arg Ser Trp Ser Val Asn 
                2565                2570                2575


Leu Asp Gln Leu Leu Val Ser Ala Gly Asp Gln Gln Arg Leu Gln Ser 
            2580                2585                2590


Val Leu Ser Ser Val Gly Ser Lys Ser Thr Ile Leu Thr Leu Ile Gln 
        2595                2600                2605


Glu Ala Lys Ala Gln Ser Glu Asn Glu Glu Asp Val Cys Phe Ile Val 
    2610                2615                2620


Leu Asn Arg Lys Glu Gly Ser Gly Leu Gly Phe Ser Val Ala Gly Gly 
2625                2630                2635                2640


Thr Asp Val Glu Pro Lys Ser Ile Thr Val His Arg Val Phe Ser Gln 
                2645                2650                2655


Gly Ala Ala Ser Gln Glu Gly Thr Met Asn Arg Gly Asp Phe Leu Leu 
            2660                2665                2670


Ser Val Asn Gly Ala Ser Leu Ala Gly Leu Ala His Gly Asn Val Leu 
        2675                2680                2685


Lys Val Leu His Gln Ala Gln Leu His Lys Asp Ala Leu Val Val Ile 
    2690                2695                2700


Lys Lys Gly Met Asp Gln Pro Arg Pro Ser Ala Arg Gln Glu Pro Pro 
2705                2710                2715                2720


Thr Ala Asn Gly Lys Gly Leu Leu Ser Arg Lys Thr Ile Pro Leu Glu 
                2725                2730                2735


Pro Gly Ile Gly Arg Ser Val Ala Val His Asp Ala Leu Cys Val Glu 
            2740                2745                2750


Val Leu Lys Thr Ser Ala Gly Leu Gly Leu Ser Leu Asp Gly Gly Lys 
        2755                2760                2765


Ser Ser Val Thr Gly Asp Gly Pro Leu Val Ile Lys Arg Val Tyr Lys 
    2770                2775                2780


Gly Gly Ala Ala Glu Gln Ala Gly Ile Ile Glu Ala Gly Asp Glu Ile 
2785                2790                2795                2800


Leu Ala Ile Asn Gly Lys Pro Leu Val Gly Leu Met His Phe Asp Ala 
                2805                2810                2815


Trp Asn Ile Met Lys Ser Val Pro Glu Gly Pro Val Gln Leu Leu Ile 
            2820                2825                2830


Arg Lys His Arg Asn Ser Ser 
        2835


<210>  257
<211>  2676
<212>  DNA
<213>  Homo sapiens

<400>  257
atattggaaa ggcgccgccg ccgcctccgc cttggagctc ggggtgtttc ggggactgcg     60

gccacaggca ggaaggcgct cctctcctgc cccgccgacg cccggccagc ccgcttcgcc    120

ctgacctgtt tcctcatgac tgcccccggc cctgctgccg acggacgtcg ccccggcgtc    180

cggatttaac acggaaaccc ggatcggagg ccgcgcgggg aggaggaggg cgacccggtc    240

ggtcctgcga ccctctcggc ccggctcggc gcctcggcgg gagccatgac ctcgctgacc    300

cagcgcagct ccggcctggt gcagcggcgc accgaggcct cccgcaacgc cgccgacaag    360

gagcgggcgg cgggcggcgg cgccggcagc agcgaggacg acgcgcagag ccgccgcgac    420

gagcaggacg acgacgacaa gggcgactcc aaggaaacgc ggctgaccct gatggaggaa    480

gtgctcctgc tgggcctcaa ggaccgcgag ggttacacat cattttggaa tgactgtata    540

tcatctggat tacgtggctg tatgttaatt gaattagcat tgagaggaag gttacaacta    600

gaggcttgtg gaatgagacg taaaagtcta ttaacaagaa aggtaatctg taagtcagat    660

gctccaacag gggatgttct tcttgatgaa gctctgaagc atgttaagga aactcagcct    720

ccagaaacgg tccagaactg gattgaatta cttagtggtg agacatggaa tccattaaaa    780

ttgcattatc agttaagaaa tgtacgggaa cgattagcta aaaacctggt ggaaaagggt    840

gtattgacaa cagagaaaca gaacttccta ctttttgaca tgacaacaca tcccctcacc    900

aataacaaca ttaagcagcg cctcatcaag aaagtacagg aagccgttct tgacaaatgg    960

gtgaatgacc ctcaccgcat ggacaggcgc ttgctggccc tcatttacct ggctcatgcc   1020

tcggacgtcc tggagaatgc ttttgctcct cttctggacg agcagtatga tttggctacc   1080

aagagagtgc ggcagcttct cgacttagac cctgaagtgg aatgtctgaa ggccaacacc   1140

aatgaggttc tgtgggcggt ggtggcggcg ttcaccaagt aactctgctc ggggtgaacc   1200

attctccttt ctctcaagta aaccagtagt ttttcttctg ttgacttctg gttttctgta   1260

atttgtactt tcccacacta taattggctt ctgttttaca aaatggtggg tggctttttc   1320

ttttttgtac gtgtacagga ttctgctggt acgagaggcc ttcctctttc tgtttttaaa   1380

aaaagtttta ctgccatatt ggcattccat tccctgttgc catcctcact gttacctgtt   1440

ttgggtttct ggtctacttt gactttcaaa gtacctccag cctcctcata cgcacagctt   1500

ttggatgacc tcagcttgag tttctccata tgtgcatgta catctagcat tctgcctaca   1560

gttcagacag aagtcacaaa aaggccttca actcaccaaa ggtaaatatc tgtatctatt   1620

aggacatttt ttacatagac ttcagttgag atgtatactt agcaaaatta tttttaaatt   1680

gaaacagcac agtaaatact taatataaaa tgtcccttgg attttgcttc ccatgtaaat   1740

ctattgtatt attacacttg ttataatttt aactataaag gtccaattgt ttcacagagc   1800

cagtttggga tgggctgcat tccatttatg ctgtatatag tttgaattat atataaatta   1860

ccccttcttc tggccacccc tgctcccatc ttagtatttt gcaagatcta atcagttgta   1920

cacctggtgc ccctcgcttg cttcaatcat ggttatttga tggcaaaatc gacctcttgt   1980

cgctgaagga gagagaaaag atgtgtgtct gattggtcct gggatttttt gagctgtgcc   2040

atttatggta ctctttgcct atgcatcccc ttgttagatt ttttttaaat tttatcttac   2100

tgtttttata atttctattg ggaagaggct tgtgaccagt accaatcttg agtttctttt   2160

tctgtccaca agtaaattaa tatctgctct gaaatgtcat ttatctactc acacattctt   2220

ggggaaaaaa atcaaatgtc agtcctagca gatgttgcat gtaaattggt agcaagtaat   2280

gattacaacc cagaggatta agaattttgt aacagaaagc tctatgtttt aattttttat   2340

atacaattag gataattagc attgtcagac tataaacctt tgctttttaa agtttatttt   2400

tactatttct ttatcacttt attgtatcat caccattggt ttcataatgt aaatactata   2460

tgttgaacaa attaaatgtc aaaatttttt attaccatag tccatgttaa tagtggggct   2520

ttcaggtgtt tagagatttt ttttgttgtt gttaacattc attgcaaaag tactagatgg   2580

tgtataactc tagagttgaa ttttaaggga ttccctaata tgtatactat ctttttatct   2640

gaagtaataa ataaacaatg atcttgaaag tgcctg                             2676


<210>  258
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  258

Met Thr Ser Leu Thr Gln Arg Ser Ser Gly Leu Val Gln Arg Arg Thr 
1               5                   10                  15


Glu Ala Ser Arg Asn Ala Ala Asp Lys Glu Arg Ala Ala Gly Gly Gly 
            20                  25                  30


Ala Gly Ser Ser Glu Asp Asp Ala Gln Ser Arg Arg Asp Glu Gln Asp 
        35                  40                  45


Asp Asp Asp Lys Gly Asp Ser Lys Glu Thr Arg Leu Thr Leu Met Glu 
    50                  55                  60


Glu Val Leu Leu Leu Gly Leu Lys Asp Arg Glu Gly Tyr Thr Ser Phe 
65                  70                  75                  80


Trp Asn Asp Cys Ile Ser Ser Gly Leu Arg Gly Cys Met Leu Ile Glu 
                85                  90                  95


Leu Ala Leu Arg Gly Arg Leu Gln Leu Glu Ala Cys Gly Met Arg Arg 
            100                 105                 110


Lys Ser Leu Leu Thr Arg Lys Val Ile Cys Lys Ser Asp Ala Pro Thr 
        115                 120                 125


Gly Asp Val Leu Leu Asp Glu Ala Leu Lys His Val Lys Glu Thr Gln 
    130                 135                 140


Pro Pro Glu Thr Val Gln Asn Trp Ile Glu Leu Leu Ser Gly Glu Thr 
145                 150                 155                 160


Trp Asn Pro Leu Lys Leu His Tyr Gln Leu Arg Asn Val Arg Glu Arg 
                165                 170                 175


Leu Ala Lys Asn Leu Val Glu Lys Gly Val Leu Thr Thr Glu Lys Gln 
            180                 185                 190


Asn Phe Leu Leu Phe Asp Met Thr Thr His Pro Leu Thr Asn Asn Asn 
        195                 200                 205


Ile Lys Gln Arg Leu Ile Lys Lys Val Gln Glu Ala Val Leu Asp Lys 
    210                 215                 220


Trp Val Asn Asp Pro His Arg Met Asp Arg Arg Leu Leu Ala Leu Ile 
225                 230                 235                 240


Tyr Leu Ala His Ala Ser Asp Val Leu Glu Asn Ala Phe Ala Pro Leu 
                245                 250                 255


Leu Asp Glu Gln Tyr Asp Leu Ala Thr Lys Arg Val Arg Gln Leu Leu 
            260                 265                 270


Asp Leu Asp Pro Glu Val Glu Cys Leu Lys Ala Asn Thr Asn Glu Val 
        275                 280                 285


Leu Trp Ala Val Val Ala Ala Phe Thr Lys 
    290                 295


<210>  259
<211>  416
<212>  DNA
<213>  Homo sapiens

<400>  259
atgggcaaat tcatgaaacc tgggaaggtg gtgcttgtcc tggctggagg ctacgctgga     60

cgcaaagcca tcattgtgaa gaacaatgat gatggcacct cagatagccc cttcagccat    120

gctctggtgg ctggaattga ccgctatccc ctcaaagtga cagctgccat gggcaagaag    180

aagatctcca agaggtcaaa gatcaagtct tttgtgaaag tttataacta caatcaccta    240

atggccacaa ggtattctgt gggtatctta ttcccttaga caaaactgtc atcaataagg    300

atgtctttag agaccctgct cttaaacgca aggccccacg agaagccaag gtcaagtttg    360

aagagagata taagacaggc aagaacaagt ggttcttcca gaagctgcgg ttttag        416


<210>  260
<211>  5187
<212>  DNA
<213>  Homo sapiens

<400>  260
gggcgagcgg tgtcagcggc ggagccggat gcgggcggca tcgcggcggt cgcggccttg     60

gggatgggcg gagccccagc cgctagtgct ggtggccgcc gctgctgccc cagctggagc    120

ccgagccgcc gcctctgcgt ccgcgcgtcg ctgcttccca gggcggcggt atgctgggga    180

aaggagtagt cggcggtggc ggcggcacca aggcccccaa gccctccttc gtgtcgtacg    240

tacgccctga ggaaattcac acaaacgaaa aggaagtaac agagaaggaa gtaactcttc    300

acttgttgcc aggtgaacag ctgctttgtg aagccagcac agtactgaag tatgtccagg    360

aagattcctg tcagcatggg gtctatggga ggcttgtctg cacagacttc aagattgcct    420

tcttgggtga tgatgaatct gcattggata atgatgaaac tcaatttaag aataaggtta    480

taggagaaaa tgacattaca ctccactgtg ttgatcagat ttatggagtg tttgatgaga    540

aaaagaaaac tctctttgga caactgaaga aataccctga gaagctcatc atccactgca    600

aagaccttcg agtgttccag ttttgtctga ggtacacaaa ggaagaggaa gtcaaaagga    660

ttgtcagtgg cataattcat catacccagg ctcctaaact gcttaaacga ttatttctgt    720

tttcctatgc gactgctgca caaaacaata cagtcactga tcccaagaac cataccgtaa    780

tgtttgacac acttaaggac tggtgttggg aactggaacg gaccaaaggc aacatgaagt    840

acaaagcagt gagtgtcaac gaaggctata aagtctgtga gagattgcca gcatactttg    900

ttgtccccac ccctcttcct gaagagaatg tgcagcgctt tcagggtcat ggcataccaa    960

tatggtgttg gtcctgccac aatggaagtg cccttttgaa aatgtcagca ctgcccaaag   1020

aacaggatga cggcatttta caaatccaaa agagcttctt agatggaatt tacaagacca   1080

tccacaggcc accctatgaa attgttaaaa cggaagacct gtcaagcaac ttcctgtccc   1140

tgcaggaaat ccagactgca tactctaaat ttaaacagct atttctgata gataacagta   1200

ctgaattttg ggacacagat ataaaatggt tttctctgtt ggaaagtagc agctggcttg   1260

acataatcag acgttgcctg aaaaaagcaa tagagattac agaatgtatg gaagcacaaa   1320

acatgaatgt tcttctttta gaggagaatg catccgacct ctgctgtctc atttcctctc   1380

tggtgcaact gatgatggac ccccactgca gaaccagaat tggtttccag agcctcatcc   1440

aaaaggagtg ggtcatgggt ggccactgtt tcttggatcg ctgcaaccat ctccgccaga   1500

acgacaaaga ggaggttcct gtgttcctgc ttttcctaga ttgtgtctgg cagctggtgc   1560

accagcatcc cccggcattt gaattcacag agacttacct gactgttttg tcagatagcc   1620

tgtatatacc tatttttagc accttcttct tcaattcacc tcatcaaaaa gatactaaca   1680

tgggtagaga aggccaggat acacaaagca agcctttgaa tctgctcacc gtgtgggatt   1740

ggtcggtgca gtttgaaccc aaagcccaga cattgctcaa aaaccctctt tatgtggaaa   1800

agccaaaact ggacaaaggc caacggaaag gaatgcgctt caaacatcaa cgacaacttt   1860

ctttgccact tacacaatct aagtcatctc ccaaaagagg atttttcagg gaagaaacag   1920

atcatttaat taaaaacctt ctgggcaaga gaattagcaa acttattaat tcttctgatg   1980

agctccaaga caactttcga gagttctatg acagctggca tagcaagtcc actgactacc   2040

atggtttgtt gttaccgcat atcgaggggc ccgaaatcaa agtctgggcc cagcgctacc   2100

tacgttggat tccagaagcc caaatcctag gtggtggcca agtggccact ctgagcaaac   2160

tcttggaaat gatggaggaa gtccagagtt tacaagagaa gatcgacgag agacaccaca   2220

gccagcaggc cccccaggct gaggccccct gcctgctgag gaactctgcc cgcctctcgt   2280

ctttgtttcc tttcgctctg ctccagcgac attcctctaa gcccgtctta cccaccagtg   2340

gctggaaagc tttgggagat gaagacgatt tggccaaacg agaagatgag ttcgtggacc   2400

taggggatgt gtgacctgtt tgttgagtga ttgtgaaaga ggaatgtggg agattgggac   2460

agctgatccc tggatttgtg tcacgctaca gctcatgctg gctgggtcct tagcccggca   2520

ctccgttaga ataaacctgg gccttcggga aaagaggtgg ctctcattat ttttcatgat   2580

tctaaaagac tatgcaatta aaaccgcatc tgtagtatta ctaattggaa ggaattatta   2640

cttgacccgt aatagggttg tggccgtttt ctgatgccta agtattatac agagcccaca   2700

atggccagtt tactaccaga aagggcttca gtaagatatt cttggacttg atactttctt   2760

cagatcctct ttgtgccaag ataatttatc cagtcattgg gaatagtaag tttctgtgta   2820

acccatctca attatagaag caagttcagc tttatgtatt tgtatgggga gttgaagatt   2880

cagatagagg tattaagatg tgtggcattt acttaaacca tcacattttt ttctttctac   2940

gcccccttgc ctgtaaaaca cctgggaagt tccactggtg tcatccatcc tgatgcttca   3000

gaccaccctc ccttcttcac agaccgtgtc actttgcctg tgggtggggg ctagccagcc   3060

accaccctct tttctgtgct gccagcccca ggtcttcctc cgcctgctcc acaccactcg   3120

ccgctgtccc tctgcactcc ctgccttggt gcgtgtagtc ccagtgtctc actgccaaac   3180

ctcttggtta cgctgcgggg atctgtttct ttgcctgaga tccttcctga ggagcgtcca   3240

ttcctctgga gtctctcctt gtttggaaca aatcgcttcg cctttttcta cttgcctgct   3300

gaagctttgg agcacttgtg attgcagttt tctgccgcaa cccctgagcc gagttcctca   3360

cattctttta cctttatgga ctgatgggat tgggtcactt ttgaatgtgg ctttcatagg   3420

aaagcagctt aaacataaat atcagaagtg atgattatca tatgatacct cagtgatttt   3480

aaaagccata gaagaaactt gactatgcct ggtcaccttc ttggatctgc tgtctaaatg   3540

atatatatat gatatatatg tgatatatat atatcatata tatgatatat atatatatat   3600

cacatatata tgatatatat atgatatata tatatcacat atatatgata tatatatcat   3660

atatatgata tatatttttt ttaatgcagg aaagtatact ttgtaaggag cagatttttt   3720

tgttctcagt ggaaccctgt caaatcgcat aaaagaggaa aaaaacaaaa ctcattagaa   3780

tgttttaaat tgaatgttcg ccttttacat atatttgctc ttcagtatgg atcccaattt   3840

gaatgttaca tgttcggaaa aactttcagt tgctcaaggg caataagaaa atttgaggcc   3900

gggtgtggtg gctcacgcct gtaatcccag cactttggga ggctcaggtg ggcgaattgc   3960

ttgagcccag gagttcgaga ccagccgggg caacatggca aaaccctgtc tctactaaaa   4020

atacaaaaat tagctgggtg tggtggtgca tgcctgtagt cccagctact cgggaggctg   4080

aggtgggagg atcccgtgag cctgggaggt ggagtttgca gtgagctaag atcgtgccac   4140

tgcactccgg cctgggtgat ggagcaagac ctcgtctcag aaaattggaa actattgact   4200

aagagaagtt tctaggtttg cactgaattg tcttttgtac atacagtgaa ttgttttgct   4260

gttctcccca ctccatatta atgcaggagc caggttggtc tgttaggatg aacaaaggtt   4320

gaggggaggg caggattcgt gcatctgggg gccaaacaca tgttccgtct tgattgcctt   4380

aagagttact agcgaggtca gtgttaggct tgcaataggg attttaaaat acactaacta   4440

gttccttagc taccttcaca tacattctat aggccttctt aaattagcac taacctccac   4500

ttccttctct gccccattgc ctcccaaata tgctatggag ctatttttgt taccacgtta   4560

taacgtgaat atttatacag tagcctcttc aggctttgta attttcattc caaaaatgcc   4620

cggtgtgatg ctttacactc tacaaagtat ggtttaaagg cacaaggtca tggcctttgt   4680

catagcagtt gaatgtgcat tgacatattt ttctatgatt ttttaaaatt acaatagaaa   4740

aataagctgt tgtaacgtgt aaggtcatga caatttttgt atttatattt gaaatcagat   4800

ttctataact cgtatttgtg tacagaattc tcaatggatt tatatattgt gaaattttta   4860

tctgagattg ggatgtggat tatgcttaac agtgagagct gaaatgagac catttacttt   4920

gtttaaaatg ctgtactgtg caagtttgga aatgtaaatt aatttactgt atataatatc   4980

ttgagtttgt ttatacctcc aagtttttac actgaagata aactagcttt aattcaaaac   5040

tttttttttc tttataaggg aataagctgt tgagctaaac ctgtatactt gtgcttttta   5100

ttttctggat gcacaatgaa agtttatact tgtatctcac tgcatcatat ctgattgcag   5160

aaattaaagc acaatttaca agcaata                                       5187


<210>  261
<211>  747
<212>  PRT
<213>  Homo sapiens

<400>  261

Met Leu Gly Lys Gly Val Val Gly Gly Gly Gly Gly Thr Lys Ala Pro 
1               5                   10                  15


Lys Pro Ser Phe Val Ser Tyr Val Arg Pro Glu Glu Ile His Thr Asn 
            20                  25                  30


Glu Lys Glu Val Thr Glu Lys Glu Val Thr Leu His Leu Leu Pro Gly 
        35                  40                  45


Glu Gln Leu Leu Cys Glu Ala Ser Thr Val Leu Lys Tyr Val Gln Glu 
    50                  55                  60


Asp Ser Cys Gln His Gly Val Tyr Gly Arg Leu Val Cys Thr Asp Phe 
65                  70                  75                  80


Lys Ile Ala Phe Leu Gly Asp Asp Glu Ser Ala Leu Asp Asn Asp Glu 
                85                  90                  95


Thr Gln Phe Lys Asn Lys Val Ile Gly Glu Asn Asp Ile Thr Leu His 
            100                 105                 110


Cys Val Asp Gln Ile Tyr Gly Val Phe Asp Glu Lys Lys Lys Thr Leu 
        115                 120                 125


Phe Gly Gln Leu Lys Lys Tyr Pro Glu Lys Leu Ile Ile His Cys Lys 
    130                 135                 140


Asp Leu Arg Val Phe Gln Phe Cys Leu Arg Tyr Thr Lys Glu Glu Glu 
145                 150                 155                 160


Val Lys Arg Ile Val Ser Gly Ile Ile His His Thr Gln Ala Pro Lys 
                165                 170                 175


Leu Leu Lys Arg Leu Phe Leu Phe Ser Tyr Ala Thr Ala Ala Gln Asn 
            180                 185                 190


Asn Thr Val Thr Asp Pro Lys Asn His Thr Val Met Phe Asp Thr Leu 
        195                 200                 205


Lys Asp Trp Cys Trp Glu Leu Glu Arg Thr Lys Gly Asn Met Lys Tyr 
    210                 215                 220


Lys Ala Val Ser Val Asn Glu Gly Tyr Lys Val Cys Glu Arg Leu Pro 
225                 230                 235                 240


Ala Tyr Phe Val Val Pro Thr Pro Leu Pro Glu Glu Asn Val Gln Arg 
                245                 250                 255


Phe Gln Gly His Gly Ile Pro Ile Trp Cys Trp Ser Cys His Asn Gly 
            260                 265                 270


Ser Ala Leu Leu Lys Met Ser Ala Leu Pro Lys Glu Gln Asp Asp Gly 
        275                 280                 285


Ile Leu Gln Ile Gln Lys Ser Phe Leu Asp Gly Ile Tyr Lys Thr Ile 
    290                 295                 300


His Arg Pro Pro Tyr Glu Ile Val Lys Thr Glu Asp Leu Ser Ser Asn 
305                 310                 315                 320


Phe Leu Ser Leu Gln Glu Ile Gln Thr Ala Tyr Ser Lys Phe Lys Gln 
                325                 330                 335


Leu Phe Leu Ile Asp Asn Ser Thr Glu Phe Trp Asp Thr Asp Ile Lys 
            340                 345                 350


Trp Phe Ser Leu Leu Glu Ser Ser Ser Trp Leu Asp Ile Ile Arg Arg 
        355                 360                 365


Cys Leu Lys Lys Ala Ile Glu Ile Thr Glu Cys Met Glu Ala Gln Asn 
    370                 375                 380


Met Asn Val Leu Leu Leu Glu Glu Asn Ala Ser Asp Leu Cys Cys Leu 
385                 390                 395                 400


Ile Ser Ser Leu Val Gln Leu Met Met Asp Pro His Cys Arg Thr Arg 
                405                 410                 415


Ile Gly Phe Gln Ser Leu Ile Gln Lys Glu Trp Val Met Gly Gly His 
            420                 425                 430


Cys Phe Leu Asp Arg Cys Asn His Leu Arg Gln Asn Asp Lys Glu Glu 
        435                 440                 445


Val Pro Val Phe Leu Leu Phe Leu Asp Cys Val Trp Gln Leu Val His 
    450                 455                 460


Gln His Pro Pro Ala Phe Glu Phe Thr Glu Thr Tyr Leu Thr Val Leu 
465                 470                 475                 480


Ser Asp Ser Leu Tyr Ile Pro Ile Phe Ser Thr Phe Phe Phe Asn Ser 
                485                 490                 495


Pro His Gln Lys Asp Thr Asn Met Gly Arg Glu Gly Gln Asp Thr Gln 
            500                 505                 510


Ser Lys Pro Leu Asn Leu Leu Thr Val Trp Asp Trp Ser Val Gln Phe 
        515                 520                 525


Glu Pro Lys Ala Gln Thr Leu Leu Lys Asn Pro Leu Tyr Val Glu Lys 
    530                 535                 540


Pro Lys Leu Asp Lys Gly Gln Arg Lys Gly Met Arg Phe Lys His Gln 
545                 550                 555                 560


Arg Gln Leu Ser Leu Pro Leu Thr Gln Ser Lys Ser Ser Pro Lys Arg 
                565                 570                 575


Gly Phe Phe Arg Glu Glu Thr Asp His Leu Ile Lys Asn Leu Leu Gly 
            580                 585                 590


Lys Arg Ile Ser Lys Leu Ile Asn Ser Ser Asp Glu Leu Gln Asp Asn 
        595                 600                 605


Phe Arg Glu Phe Tyr Asp Ser Trp His Ser Lys Ser Thr Asp Tyr His 
    610                 615                 620


Gly Leu Leu Leu Pro His Ile Glu Gly Pro Glu Ile Lys Val Trp Ala 
625                 630                 635                 640


Gln Arg Tyr Leu Arg Trp Ile Pro Glu Ala Gln Ile Leu Gly Gly Gly 
                645                 650                 655


Gln Val Ala Thr Leu Ser Lys Leu Leu Glu Met Met Glu Glu Val Gln 
            660                 665                 670


Ser Leu Gln Glu Lys Ile Asp Glu Arg His His Ser Gln Gln Ala Pro 
        675                 680                 685


Gln Ala Glu Ala Pro Cys Leu Leu Arg Asn Ser Ala Arg Leu Ser Ser 
    690                 695                 700


Leu Phe Pro Phe Ala Leu Leu Gln Arg His Ser Ser Lys Pro Val Leu 
705                 710                 715                 720


Pro Thr Ser Gly Trp Lys Ala Leu Gly Asp Glu Asp Asp Leu Ala Lys 
                725                 730                 735


Arg Glu Asp Glu Phe Val Asp Leu Gly Asp Val 
            740                 745


<210>  262
<211>  4746
<212>  DNA
<213>  Homo sapiens

<400>  262
gttctccgct gaggaggagc ggggcagagg agggaggcag cgggtgagag ttcagagttc     60

agcagcagca gcccgagccc atgattccca tatgccctgt agtttctttc acctatgtgc    120

ccagccggct gggggaagat gccaaaatgg cgaccggcaa ctactttgga ttcacccaca    180

gcggggcggc ggcggcggcg gctgcggccc aatatagcca gcagccagct tcgggtgtag    240

cctattctca tccaactaca gttgctagct acactgtcca tcaggctcca gtagctgctc    300

acacagttac tgctgcctat gcaccagcag ccgccacagt tgcagttgcc aggcctgctc    360

cagtagctgt tgcagctgct gcaacagctg ctgcttatgg aggctacccc actgcacaca    420

cagcaactga ctatggttat actcagaggc aacaagaagc accaccacca ccacccccag    480

ctactacaca aaactaccag gattcatact catatgtaag gtccacagct cctgctgtag    540

cttatgatag taagcaatac taccaacaac caacagcaac tgctgctgct gtagctgccg    600

ctgcccaacc tcagccttct gttgctgaaa cttactatca gacagccccc aaagcaggtt    660

acagccaagg tgcaactcag tatactcaag cccagcaaac tcgacaagtg acagccataa    720

aaccagccac accaagtcca gctaccacta ctttctccat ctatcctgta tcctccaccg    780

tacagccagt agcagctgcg gctactgtgg tgccatccta tactcagagt gctacttaca    840

gtaccacagc agttacatat tctggtacgt cttattcagg ttatgaagca gcagtgtatt    900

cagctgcatc ttcctactat caacagcagc agcagcaaca gaagcaggca gcagcagcag    960

ctgctgctgc tgctgcaaca gctgcctgga cagggaccac ctttactaaa aaagcaccat   1020

tccaaaataa acaactgaaa ccaaaacagc ctcccaaacc accacagatt cactattgtg   1080

atgtttgtaa gatcagctgt gctggaccac agacttataa agaacattta gaaggacaga   1140

aacataaaaa aaaagaagct gcattgaaag cctcacaaaa taccagcagc agcaacagtt   1200

ctactcgtgg gactcaaaat cagctacgtt gtgagctctg cgatgtgtct tgtacaggag   1260

cagatgcgta tgctgcccac attcgtggtg ctaagcatca gaaagtggtt aagttacaca   1320

caaaacttgg taaacccatt ccatcaacag aaccaaatgt tgttagccaa gctacttctt   1380

caacagctgt atctgcttca aagccgactg cctctccttc aagcattgca gcaaacaatt   1440

gtactgtgaa tacgtcatca gttgcaacgt cttcaatgaa gggtcttacg actacaggaa   1500

actcgtctct taatagcaca tctaacacta aagtatcagc agtgcctaca aatatggctg   1560

ccaagaaaac atctaccccc aaaataaatt ttgttggtgg taataagctg cagtcaacag   1620

gaaataaagc agaagacata aaaggaaccg aatgtgttaa aagtactcct gtcacttctg   1680

ctgtgcagat tcctgaagta aagcaagaca cagtgtcaga accagtcaca cctgcatctc   1740

ttgctgcttt acagagtgat gtgcagccag tgggccatga ttatgtggaa gaggtacgaa   1800

atgatgaagg aaaagtaatt cggttccatt gtaaattatg cgagtgcagc tttaatgatc   1860

ccaatgctaa ggagatgcac ttaaaagggc gaagacacag acttcaatat aaaaaaaaag   1920

taaatccaga tttgcaagta gaagtaaagc ctagtattcg agcaagaaag attcaagaag   1980

agaaaatgag gaagcaaatg cagaaggagg agtactggcg aagacgagaa gaagaggagc   2040

gttggagaat ggaaatgaga cgttatgaag aggacatgta ctggaggaga atggaggaag   2100

aacaacatca ttgggatgat cgccgccgaa tgccagatgg aggttatcct catggtcctc   2160

caggcccatt aggccttctg ggagtccgac caggcatgcc tcctcagcct caggggcctg   2220

cacccttacg tcgtcctgac tcatctgatg accgttatgt aatgacaaaa catgccacca   2280

tttatccaac tgaagaggag ttacaggcag ttcagaaaat tgtttctatt actgaacgtg   2340

ctttaaaact cgtttcagac agtttgtctg aacatgagaa gaacaagaac aaagagggag   2400

atgataagaa agagggaggt aaagacagag ctttgaaagg agttttgcga gtgggagtat   2460

tggcaaaagg attacttctc cgaggagata gaaatgtcaa ccttgttttg ctgtgctcag   2520

agaaaccttc aaagacatta ttaagccgta ttgcagaaaa cctacccaaa cagcttgctg   2580

ttataagccc tgagaagtat gacataaaat gtgctgtatc tgaagcggca ataattttga   2640

attcatgtgt ggaacccaaa atgcaagtca ctatcacact gacatctcca attattcgag   2700

aagagaacat gagggaagga gatgtaacct cgggtatggt gaaagaccca ccggacgtct   2760

tggacaggca aaaatgcctt gacgctctgg ctgctctacg ccacgctaag tggttccagg   2820

ctagagctaa tggtctgcag tcctgtgtga ttatcatacg cattcttcga gacctctgtc   2880

agcgagttcc aacttggtct gattttccaa gctgggctat ggagttacta gtagagaaag   2940

caatcagcag tgcttctagc cctcagagcc ctggggatgc actgagaaga gtttttgaat   3000

gcatttcttc agggattatt cttaaaggta gtcctggact tctggatcct tgtgaaaagg   3060

atccctttga taccttggca acaatgactg accagcagcg tgaagacatc acatccagtg   3120

cacagtttgc attgagactc cttgcattcc gccagataca caaagttcta ggcatggatc   3180

cattaccgca aatgagccaa cgttttaaca tccacaacaa caggaaacga agaagagata   3240

gtgatggagt tgatggattt gaagctgagg ggaaaaaaga caaaaaagat tatgataact   3300

tttaaaaagt gtctgtaaat cttcagtgtt aaaaaaacag atgcccattt gttggctgtt   3360

tttcattcat aataatgtct acattgaaaa atttatcaag aatttaaagg atttcatgga   3420

agaaccaagt ttttctatga tattaaaaaa tgtacagtgt taggtattat ttgaatggaa   3480

agacacccaa aaaaaaaaat gtgctccgac tagggggaaa acagtagttc cgattttttc   3540

ccattatttt tattttattt tctggttgcc ctagcttccc cccctatttt tgtgtctttt   3600

attaactagt gcattgtctt attaaatctt cactgtattt aatgcaggat gtgtgcttca   3660

gttgctctgt gtattttgat attttaattt agaggttttg tttgcttttt gacactagtt   3720

gtaagttact ttgttataga tggtatcctt taccccttct taatatttta cagcagtacg   3780

tttttttgta acgtgagact gcagagtttg tttttctata tgtgaaggat tacaacacaa   3840

aaagttatcc tgccattcga gtgctcagaa ctgaatgttt ctgcagatct tgtggcattt   3900

gtctctagtg tgatatataa aggtgtaatt aagacagagt tctgttaatc taatcaagtt   3960

tgctgttagt tgtgcattag cagtataaaa gctaatatat actatatggt cttgcaacag   4020

ttttaaagcc tctgcataat tgataataaa aatgcatgac attcttgttt ttaatagact   4080

tttaaaatca taattttagg tttaacacgt agatctttgt acagttgact ttttgacata   4140

gcaaggccaa aaataacttt ctgaatattt ttttcttgtg tataagtgga aagggcattt   4200

ttcacatata agtgggctaa ccaatatttt caaaagaact tcatcattgt acaactaaca   4260

acagtaacta gcccttaatt atggtgacag ttccttattg gtgtgtgtga gattactcta   4320

gcaactatta cagtataaca cagatgatct tctccacaca ccccatcacc cagataattt   4380

acagttctgt taacagtgag gttgataaag tattactgat aaaaaattat ctaaggaaaa   4440

aaacagaaaa ttatttggtg tggccatctt acctgcttat gtctcctaca caaagctaaa   4500

tattctagca gtgatgtaat gaaaaattac atcttactgt tgatatatgt atgctctggt   4560

acacagatgt cattttgttg tcacagcact acagtgaaat acacaaaaaa tgaaattcat   4620

ataatgactt aaatgtatta tatgttagaa ttgacaacat aaactacttt tgctttgaaa   4680

tgatgtatgc ttcagtaaaa tcatattcaa atttaaaaaa aaaaaaaaaa aaaaaaaaaa   4740

aaaaaa                                                              4746


<210>  263
<211>  1074
<212>  PRT
<213>  Homo sapiens

<400>  263

Met Ile Pro Ile Cys Pro Val Val Ser Phe Thr Tyr Val Pro Ser Arg 
1               5                   10                  15


Leu Gly Glu Asp Ala Lys Met Ala Thr Gly Asn Tyr Phe Gly Phe Thr 
            20                  25                  30


His Ser Gly Ala Ala Ala Ala Ala Ala Ala Ala Gln Tyr Ser Gln Gln 
        35                  40                  45


Pro Ala Ser Gly Val Ala Tyr Ser His Pro Thr Thr Val Ala Ser Tyr 
    50                  55                  60


Thr Val His Gln Ala Pro Val Ala Ala His Thr Val Thr Ala Ala Tyr 
65                  70                  75                  80


Ala Pro Ala Ala Ala Thr Val Ala Val Ala Arg Pro Ala Pro Val Ala 
                85                  90                  95


Val Ala Ala Ala Ala Thr Ala Ala Ala Tyr Gly Gly Tyr Pro Thr Ala 
            100                 105                 110


His Thr Ala Thr Asp Tyr Gly Tyr Thr Gln Arg Gln Gln Glu Ala Pro 
        115                 120                 125


Pro Pro Pro Pro Pro Ala Thr Thr Gln Asn Tyr Gln Asp Ser Tyr Ser 
    130                 135                 140


Tyr Val Arg Ser Thr Ala Pro Ala Val Ala Tyr Asp Ser Lys Gln Tyr 
145                 150                 155                 160


Tyr Gln Gln Pro Thr Ala Thr Ala Ala Ala Val Ala Ala Ala Ala Gln 
                165                 170                 175


Pro Gln Pro Ser Val Ala Glu Thr Tyr Tyr Gln Thr Ala Pro Lys Ala 
            180                 185                 190


Gly Tyr Ser Gln Gly Ala Thr Gln Tyr Thr Gln Ala Gln Gln Thr Arg 
        195                 200                 205


Gln Val Thr Ala Ile Lys Pro Ala Thr Pro Ser Pro Ala Thr Thr Thr 
    210                 215                 220


Phe Ser Ile Tyr Pro Val Ser Ser Thr Val Gln Pro Val Ala Ala Ala 
225                 230                 235                 240


Ala Thr Val Val Pro Ser Tyr Thr Gln Ser Ala Thr Tyr Ser Thr Thr 
                245                 250                 255


Ala Val Thr Tyr Ser Gly Thr Ser Tyr Ser Gly Tyr Glu Ala Ala Val 
            260                 265                 270


Tyr Ser Ala Ala Ser Ser Tyr Tyr Gln Gln Gln Gln Gln Gln Gln Lys 
        275                 280                 285


Gln Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Thr Ala Ala Trp Thr 
    290                 295                 300


Gly Thr Thr Phe Thr Lys Lys Ala Pro Phe Gln Asn Lys Gln Leu Lys 
305                 310                 315                 320


Pro Lys Gln Pro Pro Lys Pro Pro Gln Ile His Tyr Cys Asp Val Cys 
                325                 330                 335


Lys Ile Ser Cys Ala Gly Pro Gln Thr Tyr Lys Glu His Leu Glu Gly 
            340                 345                 350


Gln Lys His Lys Lys Lys Glu Ala Ala Leu Lys Ala Ser Gln Asn Thr 
        355                 360                 365


Ser Ser Ser Asn Ser Ser Thr Arg Gly Thr Gln Asn Gln Leu Arg Cys 
    370                 375                 380


Glu Leu Cys Asp Val Ser Cys Thr Gly Ala Asp Ala Tyr Ala Ala His 
385                 390                 395                 400


Ile Arg Gly Ala Lys His Gln Lys Val Val Lys Leu His Thr Lys Leu 
                405                 410                 415


Gly Lys Pro Ile Pro Ser Thr Glu Pro Asn Val Val Ser Gln Ala Thr 
            420                 425                 430


Ser Ser Thr Ala Val Ser Ala Ser Lys Pro Thr Ala Ser Pro Ser Ser 
        435                 440                 445


Ile Ala Ala Asn Asn Cys Thr Val Asn Thr Ser Ser Val Ala Thr Ser 
    450                 455                 460


Ser Met Lys Gly Leu Thr Thr Thr Gly Asn Ser Ser Leu Asn Ser Thr 
465                 470                 475                 480


Ser Asn Thr Lys Val Ser Ala Val Pro Thr Asn Met Ala Ala Lys Lys 
                485                 490                 495


Thr Ser Thr Pro Lys Ile Asn Phe Val Gly Gly Asn Lys Leu Gln Ser 
            500                 505                 510


Thr Gly Asn Lys Ala Glu Asp Ile Lys Gly Thr Glu Cys Val Lys Ser 
        515                 520                 525


Thr Pro Val Thr Ser Ala Val Gln Ile Pro Glu Val Lys Gln Asp Thr 
    530                 535                 540


Val Ser Glu Pro Val Thr Pro Ala Ser Leu Ala Ala Leu Gln Ser Asp 
545                 550                 555                 560


Val Gln Pro Val Gly His Asp Tyr Val Glu Glu Val Arg Asn Asp Glu 
                565                 570                 575


Gly Lys Val Ile Arg Phe His Cys Lys Leu Cys Glu Cys Ser Phe Asn 
            580                 585                 590


Asp Pro Asn Ala Lys Glu Met His Leu Lys Gly Arg Arg His Arg Leu 
        595                 600                 605


Gln Tyr Lys Lys Lys Val Asn Pro Asp Leu Gln Val Glu Val Lys Pro 
    610                 615                 620


Ser Ile Arg Ala Arg Lys Ile Gln Glu Glu Lys Met Arg Lys Gln Met 
625                 630                 635                 640


Gln Lys Glu Glu Tyr Trp Arg Arg Arg Glu Glu Glu Glu Arg Trp Arg 
                645                 650                 655


Met Glu Met Arg Arg Tyr Glu Glu Asp Met Tyr Trp Arg Arg Met Glu 
            660                 665                 670


Glu Glu Gln His His Trp Asp Asp Arg Arg Arg Met Pro Asp Gly Gly 
        675                 680                 685


Tyr Pro His Gly Pro Pro Gly Pro Leu Gly Leu Leu Gly Val Arg Pro 
    690                 695                 700


Gly Met Pro Pro Gln Pro Gln Gly Pro Ala Pro Leu Arg Arg Pro Asp 
705                 710                 715                 720


Ser Ser Asp Asp Arg Tyr Val Met Thr Lys His Ala Thr Ile Tyr Pro 
                725                 730                 735


Thr Glu Glu Glu Leu Gln Ala Val Gln Lys Ile Val Ser Ile Thr Glu 
            740                 745                 750


Arg Ala Leu Lys Leu Val Ser Asp Ser Leu Ser Glu His Glu Lys Asn 
        755                 760                 765


Lys Asn Lys Glu Gly Asp Asp Lys Lys Glu Gly Gly Lys Asp Arg Ala 
    770                 775                 780


Leu Lys Gly Val Leu Arg Val Gly Val Leu Ala Lys Gly Leu Leu Leu 
785                 790                 795                 800


Arg Gly Asp Arg Asn Val Asn Leu Val Leu Leu Cys Ser Glu Lys Pro 
                805                 810                 815


Ser Lys Thr Leu Leu Ser Arg Ile Ala Glu Asn Leu Pro Lys Gln Leu 
            820                 825                 830


Ala Val Ile Ser Pro Glu Lys Tyr Asp Ile Lys Cys Ala Val Ser Glu 
        835                 840                 845


Ala Ala Ile Ile Leu Asn Ser Cys Val Glu Pro Lys Met Gln Val Thr 
    850                 855                 860


Ile Thr Leu Thr Ser Pro Ile Ile Arg Glu Glu Asn Met Arg Glu Gly 
865                 870                 875                 880


Asp Val Thr Ser Gly Met Val Lys Asp Pro Pro Asp Val Leu Asp Arg 
                885                 890                 895


Gln Lys Cys Leu Asp Ala Leu Ala Ala Leu Arg His Ala Lys Trp Phe 
            900                 905                 910


Gln Ala Arg Ala Asn Gly Leu Gln Ser Cys Val Ile Ile Ile Arg Ile 
        915                 920                 925


Leu Arg Asp Leu Cys Gln Arg Val Pro Thr Trp Ser Asp Phe Pro Ser 
    930                 935                 940


Trp Ala Met Glu Leu Leu Val Glu Lys Ala Ile Ser Ser Ala Ser Ser 
945                 950                 955                 960


Pro Gln Ser Pro Gly Asp Ala Leu Arg Arg Val Phe Glu Cys Ile Ser 
                965                 970                 975


Ser Gly Ile Ile Leu Lys Gly Ser Pro Gly Leu Leu Asp Pro Cys Glu 
            980                 985                 990


Lys Asp Pro Phe Asp Thr Leu Ala Thr Met Thr Asp Gln Gln Arg Glu 
        995                 1000                1005


Asp Ile Thr Ser Ser Ala Gln Phe Ala Leu Arg Leu Leu Ala Phe Arg 
    1010                1015                1020


Gln Ile His Lys Val Leu Gly Met Asp Pro Leu Pro Gln Met Ser Gln 
1025                1030                1035                1040


Arg Phe Asn Ile His Asn Asn Arg Lys Arg Arg Arg Asp Ser Asp Gly 
                1045                1050                1055


Val Asp Gly Phe Glu Ala Glu Gly Lys Lys Asp Lys Lys Asp Tyr Asp 
            1060                1065                1070


Asn Phe 



<210>  264
<211>  3952
<212>  DNA
<213>  Homo sapiens

<400>  264
actcgattgt aatttcatcc ccgggccggt cgagcctccc tccctcccgc ggccagccct     60

tccctcccag tcggcctcct tcgtcgcccc cgcccccgcg aaaagccctg cagcttgcag    120

ccggcttcac tcgcgcacgc cgacctcccg gctgcagtcc tacctcttgg aactacccgt    180

gtttccgggc ccagccctcg cagcccccca cctcctcgcc ccggcccggg gatccgttgg    240

ggccgcgtcc cccacgcgcc cccggagacg ccctttccgt gtgcgcccgg gacttggtga    300

aactttgcag gcgccggctg cgaaatggat ttaatccgag gcgtcttgct ccggctcctg    360

ctcctggctt ccagcctcgg acccggcgcg gtgtcgctcc gagcggccat ccgaaaacca    420

ggcaaggtag ggcctcctct tgacatcaag ctgggcgcat tgaactgtac ggctttcagc    480

atccagtgga aaatgccaag gcatcctgga agtcccatcc ttgggtacac tgtcttttac    540

tctgaggttg gcgcagataa atccctgcag gagcagttgc acagcgtgcc tctcagccgg    600

gacatcccga ccacggagga agtgattgga gatttgaaac caggcactga atatcgtgtg    660

agcatagcag cttacagcca ggctggcaaa gggcggctga gctctcctcg gcatgtcacc    720

actttgtccc aagattcctg cctgcctcct gcagctcccc agcagccaca tgtcattgtg    780

gtttcggatt ctgaggtggc cctgtcttgg aaacctggag cgagtgaagg aagcgcccct    840

attcagtact attctgtgga attcatcagg ccagatttcg acaagaagtg gacctcaatc    900

catgagcgga tccagatgga ctccatggtt atcaagggcc tcgatccaga taccaactac    960

cagtttgccg tgagggcaat gaattcccat ggccccagcc cccgcagctg gcccagtgac   1020

atcatccgga ccctctgccc tgaggaggcg ggaagtggcc gctatggacc ccgttatatc   1080

accgacatgg gagctggtga ggatgatgaa ggatttgaag acgacttaga tttggatatt   1140

tcctttgagg aggttaaacc acttcctgct accaaaggag ggaataagaa atttttggtg   1200

gaaagcaaga agatgtctat atctaaccca aagaccattt ctaggctcat cccccctacc   1260

tcagcatctc tccctgtgac cacggtggct ccccagccca ttcccataca gagaaagggg   1320

aagaatggtg tggccataat gtcaaggctc tttgacatgc cttgtgatga aactctctgc   1380

tctgctgaca gcttctgtgt caatgactac acctgggggg gctcgcgatg ccagtgcacc   1440

ctgggcaaag gtggtgagag ctgctcagaa gatattgtta tccagtatcc tcagttcttt   1500

ggccactcct atgtaacgtt tgaacctctg aagaattctt atcaggcatt tcaaattact   1560

cttgaattta gggcggaggc agaggatggc ttactgctct actgtgggga gaacgaacac   1620

gggagggggg atttcatgtc cctggctatc atccgacgct ccctgcagtt caggtttaat   1680

tgtggaactg gggttgccat catcgtaagt gagaccaaaa tcaaactagg gggttggcac   1740

acggttatgc tctacagaga tgggctgaac gggctgctgc agctgaacaa tggcacccca   1800

gtgacaggcc agtctcaggg ccaatacagt aaaattactt tccggacacc tctctatctt   1860

ggtggcgctc ccagcgctta ctggttggtt agagcaacag ggacaaaccg aggctttcaa   1920

ggctgtgtgc agtcgctcgc tgtgaatggg aggagaattg acatgaggcc ctggcccctg   1980

ggaaaagcac tcagtggggc tgatgtgggg gaatgcagca gtggaatctg tgatgaggcc   2040

tcgtgcatcc atggtggcac ctgcacagca atcaaagccg actcctacat ttgcctctgt   2100

ccccttgggt ttaaaggtcg acactgtgaa gatgctttca ccttgaccat tcctcagttc   2160

agagagtctc tgagatctta cgctgcaact ccctggccac tggagcccca gcattacctt   2220

tccttcatgg aatttgagat cacatttcgg ccagactcag gagatggtgt cctcctgtac   2280

agctatgaca caggcagcaa agacttcctg tccatcaact tggcaggggg ccacgtggag   2340

ttccgctttg actgtggctc tgggaccggt gtcctcagga gtgaagatcc cctcaccctg   2400

ggcaactggc acgagcttcg tgtatctcgc acagcaaaga atggaatctt acaggtggat   2460

aagcagaaga tagtggaggg aatggcagag ggaggcttca cacagattaa gtgcaacaca   2520

gacattttca ttggcggagt ccccaattat gatgatgtga agaagaactc gggtgtcctg   2580

aagcctttca gcgggagcat ccagaagatc atcctgaatg accgaaccat ccatgtgaag   2640

catgacttca cctccggagt gaatgtggag aatgcggccc acccctgtgt gagagcccct   2700

tgtgcccatg ggggcagctg ccggcccagg aaggagggct atgactgtga ctgccccttg   2760

ggctttgagg ggcttcactg ccagaaagcg atcatagaag ccattgagat cccgcagttt   2820

atcggccgca gttacctgac gtatgacaac ccagatatct tgaagagggt gtcaggatca   2880

agatcaaatg tgttcatgag gtttaaaaca actgccaagg atggcctttt gctgtggagg   2940

ggagacagcc ccatgagacc caacagcgac ttcatttcct tgggccttcg ggatggagcc   3000

ctcgtgttca gctataacct gggcagtggt gtggcatcca tcatggtgaa tggctccttc   3060

aacgatggtc ggtggcaccg agttaaggcc gttagggatg gccagtcagg aaagataacc   3120

gtggatgact atggagccag aacaggcaaa tccccaggca tgatgcggca gcttaacatc   3180

aatggagctc tgtatgtggg tggaatgaag gaaattgctc tgcacactaa caggcaatat   3240

atgagagggc tcgtgggctg tatctctcac ttcaccctgt ccaccgatta ccacatttcc   3300

ctcgtggaag atgccgtgga tgggaaaaac atcaacactt gtggagccaa gtaacaccag   3360

ctggccttgt ccaagggaca gagccttcta ttctgagaat cccaggggcc ctcagaccct   3420

gcctgatgct atatgcagag gcccagggac caggtgtgtt tcctctcacc aagaagaaag   3480

tacacactga tgagaaactg agaaccaaga caggcatccc tgggtggcct ttcctgctga   3540

cactccacga gctgacccag cagaattctc tgtgtaggaa gcatcggact ttgtccattg   3600

aatatgtagc ggctgccaga gatcacacat caatgcaaat tccagagcct gtctgctata   3660

gctcagtgac tgtgttgtga ttcatagtac attaaaaaga gagagagaga gaaagaatcc   3720

cacagggcac tattaaaata cttctctcct tccctgactc atgacactct tcctgacagc   3780

agaatgactg tgtgaccttg aacttcacat ttcccacatt ggcccttgga ttgttcggat   3840

taaccccttc cactcctcac tggctggttc actgtgttct gactagtcca taaaaataaa   3900

gatggaagga gatcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa           3952


<210>  265
<211>  1009
<212>  PRT
<213>  Homo sapiens

<400>  265

Met Asp Leu Ile Arg Gly Val Leu Leu Arg Leu Leu Leu Leu Ala Ser 
1               5                   10                  15


Ser Leu Gly Pro Gly Ala Val Ser Leu Arg Ala Ala Ile Arg Lys Pro 
            20                  25                  30


Gly Lys Val Gly Pro Pro Leu Asp Ile Lys Leu Gly Ala Leu Asn Cys 
        35                  40                  45


Thr Ala Phe Ser Ile Gln Trp Lys Met Pro Arg His Pro Gly Ser Pro 
    50                  55                  60


Ile Leu Gly Tyr Thr Val Phe Tyr Ser Glu Val Gly Ala Asp Lys Ser 
65                  70                  75                  80


Leu Gln Glu Gln Leu His Ser Val Pro Leu Ser Arg Asp Ile Pro Thr 
                85                  90                  95


Thr Glu Glu Val Ile Gly Asp Leu Lys Pro Gly Thr Glu Tyr Arg Val 
            100                 105                 110


Ser Ile Ala Ala Tyr Ser Gln Ala Gly Lys Gly Arg Leu Ser Ser Pro 
        115                 120                 125


Arg His Val Thr Thr Leu Ser Gln Asp Ser Cys Leu Pro Pro Ala Ala 
    130                 135                 140


Pro Gln Gln Pro His Val Ile Val Val Ser Asp Ser Glu Val Ala Leu 
145                 150                 155                 160


Ser Trp Lys Pro Gly Ala Ser Glu Gly Ser Ala Pro Ile Gln Tyr Tyr 
                165                 170                 175


Ser Val Glu Phe Ile Arg Pro Asp Phe Asp Lys Lys Trp Thr Ser Ile 
            180                 185                 190


His Glu Arg Ile Gln Met Asp Ser Met Val Ile Lys Gly Leu Asp Pro 
        195                 200                 205


Asp Thr Asn Tyr Gln Phe Ala Val Arg Ala Met Asn Ser His Gly Pro 
    210                 215                 220


Ser Pro Arg Ser Trp Pro Ser Asp Ile Ile Arg Thr Leu Cys Pro Glu 
225                 230                 235                 240


Glu Ala Gly Ser Gly Arg Tyr Gly Pro Arg Tyr Ile Thr Asp Met Gly 
                245                 250                 255


Ala Gly Glu Asp Asp Glu Gly Phe Glu Asp Asp Leu Asp Leu Asp Ile 
            260                 265                 270


Ser Phe Glu Glu Val Lys Pro Leu Pro Ala Thr Lys Gly Gly Asn Lys 
        275                 280                 285


Lys Phe Leu Val Glu Ser Lys Lys Met Ser Ile Ser Asn Pro Lys Thr 
    290                 295                 300


Ile Ser Arg Leu Ile Pro Pro Thr Ser Ala Ser Leu Pro Val Thr Thr 
305                 310                 315                 320


Val Ala Pro Gln Pro Ile Pro Ile Gln Arg Lys Gly Lys Asn Gly Val 
                325                 330                 335


Ala Ile Met Ser Arg Leu Phe Asp Met Pro Cys Asp Glu Thr Leu Cys 
            340                 345                 350


Ser Ala Asp Ser Phe Cys Val Asn Asp Tyr Thr Trp Gly Gly Ser Arg 
        355                 360                 365


Cys Gln Cys Thr Leu Gly Lys Gly Gly Glu Ser Cys Ser Glu Asp Ile 
    370                 375                 380


Val Ile Gln Tyr Pro Gln Phe Phe Gly His Ser Tyr Val Thr Phe Glu 
385                 390                 395                 400


Pro Leu Lys Asn Ser Tyr Gln Ala Phe Gln Ile Thr Leu Glu Phe Arg 
                405                 410                 415


Ala Glu Ala Glu Asp Gly Leu Leu Leu Tyr Cys Gly Glu Asn Glu His 
            420                 425                 430


Gly Arg Gly Asp Phe Met Ser Leu Ala Ile Ile Arg Arg Ser Leu Gln 
        435                 440                 445


Phe Arg Phe Asn Cys Gly Thr Gly Val Ala Ile Ile Val Ser Glu Thr 
    450                 455                 460


Lys Ile Lys Leu Gly Gly Trp His Thr Val Met Leu Tyr Arg Asp Gly 
465                 470                 475                 480


Leu Asn Gly Leu Leu Gln Leu Asn Asn Gly Thr Pro Val Thr Gly Gln 
                485                 490                 495


Ser Gln Gly Gln Tyr Ser Lys Ile Thr Phe Arg Thr Pro Leu Tyr Leu 
            500                 505                 510


Gly Gly Ala Pro Ser Ala Tyr Trp Leu Val Arg Ala Thr Gly Thr Asn 
        515                 520                 525


Arg Gly Phe Gln Gly Cys Val Gln Ser Leu Ala Val Asn Gly Arg Arg 
    530                 535                 540


Ile Asp Met Arg Pro Trp Pro Leu Gly Lys Ala Leu Ser Gly Ala Asp 
545                 550                 555                 560


Val Gly Glu Cys Ser Ser Gly Ile Cys Asp Glu Ala Ser Cys Ile His 
                565                 570                 575


Gly Gly Thr Cys Thr Ala Ile Lys Ala Asp Ser Tyr Ile Cys Leu Cys 
            580                 585                 590


Pro Leu Gly Phe Lys Gly Arg His Cys Glu Asp Ala Phe Thr Leu Thr 
        595                 600                 605


Ile Pro Gln Phe Arg Glu Ser Leu Arg Ser Tyr Ala Ala Thr Pro Trp 
    610                 615                 620


Pro Leu Glu Pro Gln His Tyr Leu Ser Phe Met Glu Phe Glu Ile Thr 
625                 630                 635                 640


Phe Arg Pro Asp Ser Gly Asp Gly Val Leu Leu Tyr Ser Tyr Asp Thr 
                645                 650                 655


Gly Ser Lys Asp Phe Leu Ser Ile Asn Leu Ala Gly Gly His Val Glu 
            660                 665                 670


Phe Arg Phe Asp Cys Gly Ser Gly Thr Gly Val Leu Arg Ser Glu Asp 
        675                 680                 685


Pro Leu Thr Leu Gly Asn Trp His Glu Leu Arg Val Ser Arg Thr Ala 
    690                 695                 700


Lys Asn Gly Ile Leu Gln Val Asp Lys Gln Lys Ile Val Glu Gly Met 
705                 710                 715                 720


Ala Glu Gly Gly Phe Thr Gln Ile Lys Cys Asn Thr Asp Ile Phe Ile 
                725                 730                 735


Gly Gly Val Pro Asn Tyr Asp Asp Val Lys Lys Asn Ser Gly Val Leu 
            740                 745                 750


Lys Pro Phe Ser Gly Ser Ile Gln Lys Ile Ile Leu Asn Asp Arg Thr 
        755                 760                 765


Ile His Val Lys His Asp Phe Thr Ser Gly Val Asn Val Glu Asn Ala 
    770                 775                 780


Ala His Pro Cys Val Arg Ala Pro Cys Ala His Gly Gly Ser Cys Arg 
785                 790                 795                 800


Pro Arg Lys Glu Gly Tyr Asp Cys Asp Cys Pro Leu Gly Phe Glu Gly 
                805                 810                 815


Leu His Cys Gln Lys Ala Ile Ile Glu Ala Ile Glu Ile Pro Gln Phe 
            820                 825                 830


Ile Gly Arg Ser Tyr Leu Thr Tyr Asp Asn Pro Asp Ile Leu Lys Arg 
        835                 840                 845


Val Ser Gly Ser Arg Ser Asn Val Phe Met Arg Phe Lys Thr Thr Ala 
    850                 855                 860


Lys Asp Gly Leu Leu Leu Trp Arg Gly Asp Ser Pro Met Arg Pro Asn 
865                 870                 875                 880


Ser Asp Phe Ile Ser Leu Gly Leu Arg Asp Gly Ala Leu Val Phe Ser 
                885                 890                 895


Tyr Asn Leu Gly Ser Gly Val Ala Ser Ile Met Val Asn Gly Ser Phe 
            900                 905                 910


Asn Asp Gly Arg Trp His Arg Val Lys Ala Val Arg Asp Gly Gln Ser 
        915                 920                 925


Gly Lys Ile Thr Val Asp Asp Tyr Gly Ala Arg Thr Gly Lys Ser Pro 
    930                 935                 940


Gly Met Met Arg Gln Leu Asn Ile Asn Gly Ala Leu Tyr Val Gly Gly 
945                 950                 955                 960


Met Lys Glu Ile Ala Leu His Thr Asn Arg Gln Tyr Met Arg Gly Leu 
                965                 970                 975


Val Gly Cys Ile Ser His Phe Thr Leu Ser Thr Asp Tyr His Ile Ser 
            980                 985                 990


Leu Val Glu Asp Ala Val Asp Gly Lys Asn Ile Asn Thr Cys Gly Ala 
        995                 1000                1005


Lys 



<210>  266
<211>  4142
<212>  DNA
<213>  Homo sapiens

<400>  266
gacaactgag acggctgcag accatggggc agggagcata tggagcacgg atatgccaga     60

cagagggatg attcatatcc caggcaggat ggagcagggc agtgtgctat ttcatcgtgc    120

tactcagaac ttatgaattg tttatttctg gaatttccca tttaatattt ttggactgtg    180

gttgatcgag ggtaaatgaa attgcggaaa gcaaaaatac agataagggg gactgcttgc    240

tgtacaaaga tagagacaag aggaaggagc tgtcctcaag ggccttttgt gtgaagacat    300

ctggcacaca gatacgctgc atgcaggtgg cttgagagaa catgcatcca ggccctgagg    360

aggcgggaag tggccgctat ggaccccgtt atatcaccga catgggagct ggtgaggatg    420

atgaaggatt tgaagacgac ttagatttgg atatttcctt tgaggaggtt aaaccacttc    480

ctgctaccaa aggagggaat aagaaatttt tggtggaaag caagaagatg tctatatcta    540

acccaaagac catttctagg ctcatccccc ctacctcagc atctctccct gtgaccacgg    600

tggctcccca gcccattccc atacagagaa aggggaagaa tggtgtggcc ataatgtcaa    660

ggctctttga catgccttgt gatgaaactc tctgctctgc tgacagcttc tgtgtcaatg    720

actacacctg ggggggctcg cgatgccagt gcaccctggg caaaggtggt gagagctgct    780

cagaagatat tgttatccag tatcctcagt tctttggcca ctcctatgta acgtttgaac    840

ctctgaagaa ttcttatcag gcatttcaaa ttactcttga atttagggcg gaggcagagg    900

atggcttact gctctactgt ggggagaacg aacacgggag gggggatttc atgtccctgg    960

ctatcatccg acgctccctg cagttcaggt ttaattgtgg aactggggtt gccatcatcg   1020

taagtgagac caaaatcaaa ctagggggtt ggcacacggt tatgctctac agagatgggc   1080

tgaacgggct gctgcagctg aacaatggca ccccagtgac aggccagtct cagggccaat   1140

acagtaaaat tactttccgg acacctctct atcttggtgg cgctcccagc gcttactggt   1200

tggttagagc aacagggaca aaccgaggct ttcaaggctg tgtgcagtcg ctcgctgtga   1260

atgggaggag aattgacatg aggccctggc ccctgggaaa agcactcagt ggggctgatg   1320

tgggggaatg cagcagtgga atctgtgatg aggcctcgtg catccatggt ggcacctgca   1380

cagcaatcaa agccgactcc tacatttgcc tctgtcccct tgggtttaaa ggtcgacact   1440

gtgaagatgc tttcaccttg accattcctc agttcagaga gtctctgaga tcttacgctg   1500

caactccctg gccactggag ccccagcatt acctttcctt catggaattt gagatcacat   1560

ttcggccaga ctcaggagat ggtgtcctcc tgtacagcta tgacacaggc agcaaagact   1620

tcctgtccat caacttggca gggggccacg tggagttccg ctttgactgt ggctctggga   1680

ccggtgtcct caggagtgaa gatcccctca ccctgggcaa ctggcacgag cttcgtgtat   1740

ctcgcacagc aaagaatgga atcttacagg tggataagca gaagatagtg gagggaatgg   1800

cagagggagg cttcacacag attaagtgca acacagacat tttcattggc ggagtcccca   1860

attatgatga tgtgaagaag aactcgggtg tcctgaagcc tttcagcggg agcatccaga   1920

agatcatcct gaatgaccga accatccatg tgaagcatga cttcacctcc ggagtgaatg   1980

tggagaatgc ggcccacccc tgtgtgagag ccccttgtgc ccatgggggc agctgccggc   2040

ccaggaagga gggctatgac tgtgactgcc ccttgggctt tgaggggctt cactgccaga   2100

aagcgatcat agaagccatt gagatcccgc agtttatcgg ccgcagttac ctgacgtatg   2160

acaacccaga tatcttgaag agggtgtcag gatcaagatc aaatgtgttc atgaggttta   2220

aaacaactgc caaggatggc cttttgctgt ggaggggaga cagccccatg agacccaaca   2280

gcgacttcat ttccttgggc cttcgggatg gagccctcgt gttcagctat aacctgggca   2340

gtggtgtggc atccatcatg gtgaatggct ccttcaacga tggtcggtgg caccgagtta   2400

aggccgttag ggatggccag tcaggaaaga taaccgtgga tgactatgga gccagaacag   2460

gcaaatcccc aggcatgatg cggcagctta acatcaatgg agctctgtat gtgggtggaa   2520

tgaaggaaat tgctctgcac actaacaggc aatatatgag agggctcgtg ggctgtatct   2580

ctcacttcac cctgtccacc gattaccaca tttccctcgt ggaagatgcc gtggatggga   2640

aaaacatcaa cacttgtgga gccaagtaac accagctggc cttgtccaag ggacagagcc   2700

ttctattctg agaatcccag gggccctcag accctgcctg atgctatatg cagaggccca   2760

gggaccaggt gtgtttcctc tcaccaagaa gaaagtacac actgatgaga aactgagaac   2820

caagacaggc atccctgggt ggcctttcct gctgacactc cacgagctga cccagcagaa   2880

ttctctgtgt aggaagcatc ggactttgtc cattgaatat gtagcggctg ccagagatca   2940

cacatcaatg caaattccag agcctgtctg ctatagctca gtgactgtgt tgtgattcat   3000

agtacattaa aaagagagag agagagaaag aatcccacag ggcactatta aaatacttct   3060

ctccttccct gactcatgac actcttcctg acagcagaat gactgtgtga ccttgaactt   3120

cacatttccc acattggccc ttggattgtt cggattaacc ccttccactc ctcactggct   3180

ggttcactgt gttctgacta gtccataaaa ataaagatgg aaggagatca aacacagaat   3240

cataatcata atgcggcccc ctcccccaga gcttacctcg aatgtgaaat ccctacttct   3300

tataatgcag agttaaggag ctgagccccc atgattttgt agctgtactt ttgtatgtgt   3360

atatttttat agctgcagat tgtccacaca gtatactttt ggaagtttgg gtggatgact   3420

ctgaattctt gcacaccttt cctaaaaatt tctcccaaga gagacttgtt tgggcctttt   3480

gtggtgtcag tggaatggat aggtaacttg ggtgggcaac ttggggagct gaccattctc   3540

ttttggtaaa tgttgacggc tcaagaggat gaatatgaag ctttccaaga taagcagatt   3600

aaaaggaaca tgtgttaccg aggtaggtca ctgtcatttt tgttttaaga gttgggggga   3660

gtatctatag taaacttgaa taaaggggac aaagctagaa cttattcatt cattcattca   3720

cttatggagt tgttactgat tttgcggagg tcaggttcat accaatggac actaatacaa   3780

tcagtgttcc caaggctgtg caggggtggg gggacatgct gtcaggatgg tctgagcatc   3840

tgggtgagaa ccagagaaac aggacttctt ccttctgtac catgagctgt gtccctttac   3900

tatgcaagca catgacccca gagacagctg gttcactggc agatccccat gatggactta   3960

ctaagggaaa ggtgagatga acactgcccc caaggagggg gtgaaatatg atctaactta   4020

tgcaagagcc tataattagt cccagtctcg actctacatt tgtttgtgca gcattcattc   4080

agcaaagact tttggggttt gtgcaaggca cagttttaag cacataatgt aattctaaaa   4140

ga                                                                  4142


<210>  267
<211>  775
<212>  PRT
<213>  Homo sapiens

<400>  267

Met His Pro Gly Pro Glu Glu Ala Gly Ser Gly Arg Tyr Gly Pro Arg 
1               5                   10                  15


Tyr Ile Thr Asp Met Gly Ala Gly Glu Asp Asp Glu Gly Phe Glu Asp 
            20                  25                  30


Asp Leu Asp Leu Asp Ile Ser Phe Glu Glu Val Lys Pro Leu Pro Ala 
        35                  40                  45


Thr Lys Gly Gly Asn Lys Lys Phe Leu Val Glu Ser Lys Lys Met Ser 
    50                  55                  60


Ile Ser Asn Pro Lys Thr Ile Ser Arg Leu Ile Pro Pro Thr Ser Ala 
65                  70                  75                  80


Ser Leu Pro Val Thr Thr Val Ala Pro Gln Pro Ile Pro Ile Gln Arg 
                85                  90                  95


Lys Gly Lys Asn Gly Val Ala Ile Met Ser Arg Leu Phe Asp Met Pro 
            100                 105                 110


Cys Asp Glu Thr Leu Cys Ser Ala Asp Ser Phe Cys Val Asn Asp Tyr 
        115                 120                 125


Thr Trp Gly Gly Ser Arg Cys Gln Cys Thr Leu Gly Lys Gly Gly Glu 
    130                 135                 140


Ser Cys Ser Glu Asp Ile Val Ile Gln Tyr Pro Gln Phe Phe Gly His 
145                 150                 155                 160


Ser Tyr Val Thr Phe Glu Pro Leu Lys Asn Ser Tyr Gln Ala Phe Gln 
                165                 170                 175


Ile Thr Leu Glu Phe Arg Ala Glu Ala Glu Asp Gly Leu Leu Leu Tyr 
            180                 185                 190


Cys Gly Glu Asn Glu His Gly Arg Gly Asp Phe Met Ser Leu Ala Ile 
        195                 200                 205


Ile Arg Arg Ser Leu Gln Phe Arg Phe Asn Cys Gly Thr Gly Val Ala 
    210                 215                 220


Ile Ile Val Ser Glu Thr Lys Ile Lys Leu Gly Gly Trp His Thr Val 
225                 230                 235                 240


Met Leu Tyr Arg Asp Gly Leu Asn Gly Leu Leu Gln Leu Asn Asn Gly 
                245                 250                 255


Thr Pro Val Thr Gly Gln Ser Gln Gly Gln Tyr Ser Lys Ile Thr Phe 
            260                 265                 270


Arg Thr Pro Leu Tyr Leu Gly Gly Ala Pro Ser Ala Tyr Trp Leu Val 
        275                 280                 285


Arg Ala Thr Gly Thr Asn Arg Gly Phe Gln Gly Cys Val Gln Ser Leu 
    290                 295                 300


Ala Val Asn Gly Arg Arg Ile Asp Met Arg Pro Trp Pro Leu Gly Lys 
305                 310                 315                 320


Ala Leu Ser Gly Ala Asp Val Gly Glu Cys Ser Ser Gly Ile Cys Asp 
                325                 330                 335


Glu Ala Ser Cys Ile His Gly Gly Thr Cys Thr Ala Ile Lys Ala Asp 
            340                 345                 350


Ser Tyr Ile Cys Leu Cys Pro Leu Gly Phe Lys Gly Arg His Cys Glu 
        355                 360                 365


Asp Ala Phe Thr Leu Thr Ile Pro Gln Phe Arg Glu Ser Leu Arg Ser 
    370                 375                 380


Tyr Ala Ala Thr Pro Trp Pro Leu Glu Pro Gln His Tyr Leu Ser Phe 
385                 390                 395                 400


Met Glu Phe Glu Ile Thr Phe Arg Pro Asp Ser Gly Asp Gly Val Leu 
                405                 410                 415


Leu Tyr Ser Tyr Asp Thr Gly Ser Lys Asp Phe Leu Ser Ile Asn Leu 
            420                 425                 430


Ala Gly Gly His Val Glu Phe Arg Phe Asp Cys Gly Ser Gly Thr Gly 
        435                 440                 445


Val Leu Arg Ser Glu Asp Pro Leu Thr Leu Gly Asn Trp His Glu Leu 
    450                 455                 460


Arg Val Ser Arg Thr Ala Lys Asn Gly Ile Leu Gln Val Asp Lys Gln 
465                 470                 475                 480


Lys Ile Val Glu Gly Met Ala Glu Gly Gly Phe Thr Gln Ile Lys Cys 
                485                 490                 495


Asn Thr Asp Ile Phe Ile Gly Gly Val Pro Asn Tyr Asp Asp Val Lys 
            500                 505                 510


Lys Asn Ser Gly Val Leu Lys Pro Phe Ser Gly Ser Ile Gln Lys Ile 
        515                 520                 525


Ile Leu Asn Asp Arg Thr Ile His Val Lys His Asp Phe Thr Ser Gly 
    530                 535                 540


Val Asn Val Glu Asn Ala Ala His Pro Cys Val Arg Ala Pro Cys Ala 
545                 550                 555                 560


His Gly Gly Ser Cys Arg Pro Arg Lys Glu Gly Tyr Asp Cys Asp Cys 
                565                 570                 575


Pro Leu Gly Phe Glu Gly Leu His Cys Gln Lys Ala Ile Ile Glu Ala 
            580                 585                 590


Ile Glu Ile Pro Gln Phe Ile Gly Arg Ser Tyr Leu Thr Tyr Asp Asn 
        595                 600                 605


Pro Asp Ile Leu Lys Arg Val Ser Gly Ser Arg Ser Asn Val Phe Met 
    610                 615                 620


Arg Phe Lys Thr Thr Ala Lys Asp Gly Leu Leu Leu Trp Arg Gly Asp 
625                 630                 635                 640


Ser Pro Met Arg Pro Asn Ser Asp Phe Ile Ser Leu Gly Leu Arg Asp 
                645                 650                 655


Gly Ala Leu Val Phe Ser Tyr Asn Leu Gly Ser Gly Val Ala Ser Ile 
            660                 665                 670


Met Val Asn Gly Ser Phe Asn Asp Gly Arg Trp His Arg Val Lys Ala 
        675                 680                 685


Val Arg Asp Gly Gln Ser Gly Lys Ile Thr Val Asp Asp Tyr Gly Ala 
    690                 695                 700


Arg Thr Gly Lys Ser Pro Gly Met Met Arg Gln Leu Asn Ile Asn Gly 
705                 710                 715                 720


Ala Leu Tyr Val Gly Gly Met Lys Glu Ile Ala Leu His Thr Asn Arg 
                725                 730                 735


Gln Tyr Met Arg Gly Leu Val Gly Cys Ile Ser His Phe Thr Leu Ser 
            740                 745                 750


Thr Asp Tyr His Ile Ser Leu Val Glu Asp Ala Val Asp Gly Lys Asn 
        755                 760                 765


Ile Asn Thr Cys Gly Ala Lys 
    770                 775


<210>  268
<211>  3328
<212>  DNA
<213>  Homo sapiens

<400>  268
gagacggctg cagaccatgg ggcagggagc atatggagca cggatatgcc agacagaggg     60

atgattcata tcccaggcag gatggagcag ggcagtgtgc tatttcatcg tgctactcag    120

aacttatgaa ttgtttattt ctggaatttc ccatttaata tttttggact gtggttgatc    180

gagggtaaat gaaattgcag aaagcaaaaa tacagataag ggggactgct tgctgtacaa    240

agatagagac aagaggaagg agctgtcctc aagggccttt tgtgtgaaga catctggcac    300

acagatacgc tgcatgcagg tggcttgaga gaacatgcat ccaggtttaa ttgtggaact    360

ggggttgcca tcatcgtaag tgagaccaaa atcaaactag ggggttggca cacggttatg    420

ctctacagag atgggctgaa cgggctgctg cagctgaaca atggcacccc agtgacaggc    480

cagtctcagg ggaatgcagc agtggaatct gtgatgaggc ctcgtgcatc catggtggca    540

cctgcacagc aatcaaagcc gactcctaca tttgcctctg tccccttggg tttaaaggtc    600

gacactgtga agatgctttc accttgacca ttcctcagtt cagagagtct ctgagatctt    660

acgctgcaac tccctggcca ctggagcccc agcattacct ttccttcatg gaatttgaga    720

tcacatttcg gccagactca ggagatggtg tcctcctgta cagctatgac acaggcagca    780

aagacttcct gtccatcaac ttggcagggg gccacgtgga gttccgcttt gactgtggct    840

ctgggaccgg tgtcctcagg agtgaagatc ccctcaccct gggcaactgg cacgagcttc    900

gtgtatctcg cacagcaaag aatggaatct tacaggtgga taagcagaag atagtggagg    960

gaatggcaga gggaggcttc acacagatta agtgcaacac agacattttc attggcggag   1020

tccccaatta tgatgatgtg aagaagaact cgggtgtcct gaagcctttc agcgggagca   1080

tccagaagat catcctgaat gaccgaacca tccatgtgaa gcatgacttc acctccggag   1140

tgaatgtgga gaatgcggcc cacccctgtg tgagagcccc ttgtgcccat gggggcagct   1200

gccggcccag gaaggagggc tatgactgtg actgcccctt gggctttgag gggcttcact   1260

gccagaaagc gatcatagaa gccattgaga tcccgcagtt tatcggccgc agttacctga   1320

cgtatgacaa cccagatatc ttgaagaggg tgtcaggatc aagatcaaat gtgttcatga   1380

ggtttaaaac aactgccaag gatggccttt tgctgtggag gggagacagc cccatgagac   1440

ccaacagcga cttcatttcc ttgggccttc gggatggagc cctcgtgttc agctataacc   1500

tgggcagtgg tgtggcatcc atcatggtga atggctcctt caacgatggt cggtggcacc   1560

gagttaaggc cgttagggat ggccagtcag gaaagataac cgtggatgac tatggagcca   1620

gaacaggcaa atccccaggc atgatgcggc agcttaacat caatggagct ctgtatgtgg   1680

gtggaatgaa ggaaattgct ctgcacacta acaggcaata tatgagaggg ctcgtgggct   1740

gtatctctca cttcaccctg tccaccgatt accacatttc cctcgtggaa gatgccgtgg   1800

atgggaaaaa catcaacact tgtggagcca agtaacacca gctggccttg tccaagggac   1860

agagccttct attctgagaa tcccaggggc cctcagaccc tgcctgatgc tatatgcaga   1920

ggcccaggga ccaggtgtgt ttcctctcac caagaagaaa gtacacactg atgagaaact   1980

gagaaccaag acaggcatcc ctgggtggcc tttcctgctg acactccacg agctgaccca   2040

gcagaattct ctgtgtagga agcatcggac tttgtccatt gaatatgtag cggctgccag   2100

agatcacaca tcaatgcaaa ttccagagcc tgtctgctat agctcagtga ctgtgttgtg   2160

attcatagta cattaaaaag agagagagag agaaagaatc ccacagggca ctattaaaat   2220

acttctctcc ttccctgact catgacactc ttcctgacag cagaatgact gtgtgacctt   2280

gaacttcaca tttcccacat tggcccttgg attgttcgga ttaacccctt ccactcctca   2340

ctggctggtt cactgtgttc tgactagtcc ataaaaataa agatggaagg agatcaaaca   2400

cagaatcata atcataatgc ggcccccttc cccagagctt acctcgaatg tgaaatccct   2460

acttcttata atgcagagtt aaggagctga gcccccatga ttttgtagct gtacttttgt   2520

atgtgtatat ttttatagct gcagattgtc cacacagtat acttttggaa gtttgggtgg   2580

atgactctga attcttgcac acctttccta aaaatttctc ccaagagaga cttgtttggg   2640

ccttttgtgg tgtcagtgga atggataggt aacttgggtg ggcaacttgg ggagctgacc   2700

attctctttt ggtaaatgtt gacggctcaa gaggatgaat atgaagcttt ccaagataag   2760

cagattaaaa ggaacatgtg ttaccgaggt aggtcactgt catttttgtt ttaagagttg   2820

gggggagtat ctatagtaaa cttgaataaa ggggacaaag ctagaactta ttcattcatt   2880

cattcactta tggagttgtt actgattttg cggaggtcag gttcatacca atggacacta   2940

atacaatcag tgttcccaag gctgtgcagg ggtgggggga catgctgtca ggatggtctg   3000

agcatctggg tgagaaccag agaaacagga cttcttcctt ctgtaccatg agctgtgtcc   3060

ctttactatg caagcacatg accccagaga cagctggttc actggcagat ccccatgatg   3120

gacttactaa gggaaaggtg agatgaacac tgcccccaag gagggggtga aatatgatct   3180

aacttatgca agagcctata attagtccca gtctcgactc tacatttgtt tgtgcagcat   3240

tcattcagca aagacttttg gggtttgtgc aaggcacagt tttaagcaca taatgtaatt   3300

ctaaaagatg aataaactag agaggttc                                      3328


<210>  269
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  269

Met Glu Phe Glu Ile Thr Phe Arg Pro Asp Ser Gly Asp Gly Val Leu 
1               5                   10                  15


Leu Tyr Ser Tyr Asp Thr Gly Ser Lys Asp Phe Leu Ser Ile Asn Leu 
            20                  25                  30


Ala Gly Gly His Val Glu Phe Arg Phe Asp Cys Gly Ser Gly Thr Gly 
        35                  40                  45


Val Leu Arg Ser Glu Asp Pro Leu Thr Leu Gly Asn Trp His Glu Leu 
    50                  55                  60


Arg Val Ser Arg Thr Ala Lys Asn Gly Ile Leu Gln Val Asp Lys Gln 
65                  70                  75                  80


Lys Ile Val Glu Gly Met Ala Glu Gly Gly Phe Thr Gln Ile Lys Cys 
                85                  90                  95


Asn Thr Asp Ile Phe Ile Gly Gly Val Pro Asn Tyr Asp Asp Val Lys 
            100                 105                 110


Lys Asn Ser Gly Val Leu Lys Pro Phe Ser Gly Ser Ile Gln Lys Ile 
        115                 120                 125


Ile Leu Asn Asp Arg Thr Ile His Val Lys His Asp Phe Thr Ser Gly 
    130                 135                 140


Val Asn Val Glu Asn Ala Ala His Pro Cys Val Arg Ala Pro Cys Ala 
145                 150                 155                 160


His Gly Gly Ser Cys Arg Pro Arg Lys Glu Gly Tyr Asp Cys Asp Cys 
                165                 170                 175


Pro Leu Gly Phe Glu Gly Leu His Cys Gln Lys Ala Ile Ile Glu Ala 
            180                 185                 190


Ile Glu Ile Pro Gln Phe Ile Gly Arg Ser Tyr Leu Thr Tyr Asp Asn 
        195                 200                 205


Pro Asp Ile Leu Lys Arg Val Ser Gly Ser Arg Ser Asn Val Phe Met 
    210                 215                 220


Arg Phe Lys Thr Thr Ala Lys Asp Gly Leu Leu Leu Trp Arg Gly Asp 
225                 230                 235                 240


Ser Pro Met Arg Pro Asn Ser Asp Phe Ile Ser Leu Gly Leu Arg Asp 
                245                 250                 255


Gly Ala Leu Val Phe Ser Tyr Asn Leu Gly Ser Gly Val Ala Ser Ile 
            260                 265                 270


Met Val Asn Gly Ser Phe Asn Asp Gly Arg Trp His Arg Val Lys Ala 
        275                 280                 285


Val Arg Asp Gly Gln Ser Gly Lys Ile Thr Val Asp Asp Tyr Gly Ala 
    290                 295                 300


Arg Thr Gly Lys Ser Pro Gly Met Met Arg Gln Leu Asn Ile Asn Gly 
305                 310                 315                 320


Ala Leu Tyr Val Gly Gly Met Lys Glu Ile Ala Leu His Thr Asn Arg 
                325                 330                 335


Gln Tyr Met Arg Gly Leu Val Gly Cys Ile Ser His Phe Thr Leu Ser 
            340                 345                 350


Thr Asp Tyr His Ile Ser Leu Val Glu Asp Ala Val Asp Gly Lys Asn 
        355                 360                 365


Ile Asn Thr Cys Gly Ala Lys 
    370                 375


<210>  270
<211>  2228
<212>  DNA
<213>  Homo sapiens

<400>  270
taagaggacg ttctggactc tcgggcagag ctttgtgaga gaaacaaggc tggcttcaag     60

tgatctgcaa ccagagtaat tgggatttga caaggactgt gaaaggctga ctctccctgt    120

tctctttcat gctggcaccg ggcagagtgt gggaactact gcctcaatac gatcatagaa    180

gccattgaga tcccgcagtt tatcggccgc agttacctga cgtatgacaa cccagatatc    240

ttgaagaggg tgtcaggatc aagatcaaat gtgttcatga ggtttaaaac aactgccaag    300

gatggccttt tgctgtggag gggagacagc cccatgagac ccaacagcga cttcatttcc    360

ttgggccttc gggatggagc cctcgtgttc agctataacc tgggcagtgg tgtggcatcc    420

atcatggtga atggctcctt caacgatggt cggtggcacc gagttaaggc cgttagggat    480

ggccagtcag gaaagataac cgtggatgac tatggagcca gaacaggcaa atccccaggc    540

atgatgcggc agcttaacat caatggagct ctgtatgtgg gtggaatgaa ggaaattgct    600

ctgcacacta acaggcaata tatgagaggg ctcgtgggct gtatctctca cttcaccctg    660

tccaccgatt accacatttc cctcgtggaa gatgccgtgg atgggaaaaa catcaacact    720

tgtggagcca agtaacacca gctggccttg tccaagggac agagccttct attctgagaa    780

tcccaggggc cctcagaccc tgcctgatgc tatatgcaga ggcccaggga ccaggtgtgt    840

ttcctctcac caagaagaaa gtacacactg atgagaaact gagaaccaag acaggcatcc    900

ctgggtggcc tttcctgctg acactccacg agctgaccca gcagaattct ctgtgtagga    960

agcatcggac tttgtccatt gaatatgtag cggctgccag agatcacaca tcaatgcaaa   1020

ttccagagcc tgtctgctat agctcagtga ctgtgttgtg attcatagta cattaaaaag   1080

agagagagag agaaagaatc ccacagggca ctattaaaat acttctctcc ttccctgact   1140

catgacactc ttcctgacag cagaatgact gtgtgacctt gaacttcaca tttcccacat   1200

tggcccttgg attgttcgga ttaacccctt ccactcctca ctggctggtt cactgtgttc   1260

tgactagtcc ataaaaataa agatggaagg agatcaaaca cagaatcata atcataatgc   1320

ggcccccttc cccagagctt acctcgaatg tgaaatccct acttcttata atgcagagtt   1380

aaggagctga gcccccatga ttttgtagct gtacttttgt atgtgtatat ttttatagct   1440

gcagattgtc cacacagtat acttttggaa gtttgggtgg atgactctga attcttgcac   1500

acctttccta aaaatttctc ccaagagaga cttgtttggg ccttttgtgg tgtcagtgga   1560

atggataggt aacttgggtg ggcaacttgg ggagctgacc attctctttt ggtaaatgtt   1620

gacggctcaa gaggatgaat atgaagcttt ccaagataag cagattaaaa ggaacatgtg   1680

ttaccgaggt aggtcactgt catttttgtt ttaagagttg gggggagtat ctatagtaaa   1740

cttgaataaa ggggacaaag ctagaactta ttcattcatt cattcactta tggagttgtt   1800

actgattttg cggaggtcag gttcatacca atggacacta atacaatcag tgttcccaag   1860

gctgtgcagg ggtgggggga catgctgtca ggatggtctg agcatctggg tgagaaccag   1920

agaaacagga cttcttcctt ctgtaccatg agctgtgtcc ctttactatg caagcacatg   1980

accccagaga cagctggttc actggcagat ccccatgatg gacttactaa gggaaaggtg   2040

agatgaacac tgcccccaag gagggggtga aatatgatct aacttatgca agagcctata   2100

attagtccca gtctcgactc tacatttgtt tgtgcagcat tcattcagca aagacttttg   2160

gggtttgtgc aaggcacagt tttaagcaca taatgtaatt ctaaaagatg aataaactag   2220

agaggttc                                                            2228


<210>  271
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  271

Met Arg Phe Lys Thr Thr Ala Lys Asp Gly Leu Leu Leu Trp Arg Gly 
1               5                   10                  15


Asp Ser Pro Met Arg Pro Asn Ser Asp Phe Ile Ser Leu Gly Leu Arg 
            20                  25                  30


Asp Gly Ala Leu Val Phe Ser Tyr Asn Leu Gly Ser Gly Val Ala Ser 
        35                  40                  45


Ile Met Val Asn Gly Ser Phe Asn Asp Gly Arg Trp His Arg Val Lys 
    50                  55                  60


Ala Val Arg Asp Gly Gln Ser Gly Lys Ile Thr Val Asp Asp Tyr Gly 
65                  70                  75                  80


Ala Arg Thr Gly Lys Ser Pro Gly Met Met Arg Gln Leu Asn Ile Asn 
                85                  90                  95


Gly Ala Leu Tyr Val Gly Gly Met Lys Glu Ile Ala Leu His Thr Asn 
            100                 105                 110


Arg Gln Tyr Met Arg Gly Leu Val Gly Cys Ile Ser His Phe Thr Leu 
        115                 120                 125


Ser Thr Asp Tyr His Ile Ser Leu Val Glu Asp Ala Val Asp Gly Lys 
    130                 135                 140


Asn Ile Asn Thr Cys Gly Ala Lys 
145                 150


<210>  272
<211>  4811
<212>  DNA
<213>  Homo sapiens

<400>  272
ggtcctgccc tgcgaaccag cgcggccccc tggcgctgag gctgctccgg ccatggcccc     60

tcggccccgc gcccgcccag gggtcgctgt cgcctgctgc tggctcctca ctgttgttct    120

acgctgctgc gtatcattca atgttgatgt gaaaaattca atgactttca gcggcccggt    180

ggaagacatg tttggatata ctgttcaaca atatgaaaat gaagaaggaa aatgggtgct    240

tattggttct ccgttagttg gccaacccaa aaacagaact ggagatgtct ataagtgtcc    300

agttgggaga ggtgaatcat taccttgtgt aaagttggat ctaccagtta atacatcaat    360

tcccaatgtc acagaagtaa aggagaacat gacatttgga tcaactttag tcaccaaccc    420

aaatggagga tttctggctt gtgggccctt atatgcctat agatgtggac atttgcatta    480

cacaactgga atctgttctg acgtcagccc cacatttcaa gtcgtgaatt ccattgcccc    540

tgtacaagaa tgcagcactc aactggacat agtcatagtg ctggatggtt ccaacagtat    600

ttacccatgg gacagtgtta cagctttttt aaatgacctt cttgaaagaa tggatattgg    660

tcctaaacag acacaggttg gaattgtaca gtatggagaa aacgtgaccc atgagttcaa    720

cctcaataag tattcttcca ccgaagaggt acttgttgca gcaaagaaaa tagtccagag    780

aggtggccgc cagactatga cagctcttgg aatagacaca gcaagaaagg aggcattcac    840

ggaagcccgg ggtgcccgaa gaggagttaa aaaagtcatg gttattgtga cagatggaga    900

gtctcatgac aatcatcgac tgaagaaggt catccaagac tgtgaagatg aaaacattca    960

acggttttcc atagctattc ttggcagcta taaccgagga aatttaagca ctgaaaaatt   1020

tgtggaggaa ataaaatcaa ttgcaagtga acccactgaa aagcatttct tcaatgtctc   1080

tgatgaattg gctctagtca ccattgttaa aactctggga gaaagaatat ttgccctgga   1140

agccacagct gaccagtcag cagcttcatt tgaaatggaa atgtctcaga ctggcttcag   1200

tgctcattat tcacaggact gggtcatgct tggagcagta ggagcctatg attggaatgg   1260

aacagttgtc atgcagaagg ctagtcaaat cataatccct cgaaacacaa cctttaatgt   1320

tgagtctacc aaaaagaatg aaccgcttgc ttcttattta ggttacactg taaactctgc   1380

tactgcttct tctggagatg tgctctatat tgctggacag cctcggtaca atcatacagg   1440

ccaggtcatt atctacagga tggaagatgg aaacatcaaa attctccaga cgctcagtgg   1500

agaacagatt ggttcctact ttggcagtat tttaacaaca actgacattg acaaggattc   1560

taatactgac attcttctag tcggagcccc tatgtacatg ggaacagaga aggaggagca   1620

aggaaaagtg tatgtgtatg ctctcaatca gacaaggttt gaatatcaaa tgagcctgga   1680

acctattaag cagacgtgct gttcatctcg gcagcacaat tcatgcacaa cagaaaacaa   1740

aaatgagcca tgcggggctc gttttggaac tgcaattgct gctgtaaaag acctcaatct   1800

tgatggattt aatgacatcg tgataggagc tccgctggaa gatgatcacg ggggagctgt   1860

gtacatttat catggaagtg gcaagactat aaggaaagag tatgcacaac gtattccatc   1920

aggtggggat ggtaagacac tgaaattttt tggccagtct atccacggag aaatggattt   1980

aaatggtgac ggtctgacag atgtgactat tgggggcctt ggtggtgctg ccctcttctg   2040

gtcccgagat gtggccgtag ttaaagtgac catgaatttt gagccaaata aagtgaatat   2100

tcaaaagaaa aactgccata tggagggaaa ggaaacagta tgcataaatg ctacagtgtg   2160

ttttgatgtg aaattaaagt ctaaagaaga cacgatttat gaagctgatt tgcagtaccg   2220

tgtcacccta gattcactaa gacaaatatc acgaagtttt ttctctggaa ctcaagagag   2280

aaaggttcaa aggaacatca cagttcgaaa atcagaatgc actaagcact ccttctacat   2340

gttggacaag catgactttc aggactctgt gagaataacg ttggacttta atcttaccga   2400

tccagaaaat gggcctgttc ttgatgattc tctaccaaac tcagtacatg aatatattcc   2460

ctttgccaaa gattgtggaa ataaggaaaa atgtatctca gacctcagcc tgcatgtcgc   2520

caccactgaa aaggacctgc tgattgtccg atcccagaat gataagttca acgttagcct   2580

cacagtcaaa aatacaaagg acagtgccta taacaccagg acaatagtgc attattctcc   2640

aaatctagtt ttttcaggaa ttgaggctat ccaaaaagac agttgtgaat ctaatcataa   2700

tatcacatgt aaagttggat atcccttcct gagaagagga gagatggtaa ctttcaaaat   2760

attgtttcag tttaacacat cctatctcat ggaaaatgtg accatttatt taagtgcaac   2820

aagtgacagc gaagaacctc ctgaaaccct ttctgataat gtagtaaaca tttctatccc   2880

ggtaaaatat gaagttggac tacagtttta cagctctgca agtgaatacc acatttcaat   2940

tgctgccaat gagacagtcc ctgaagttat taattctact gaggacattg gaaatgaaat   3000

taatatcttc tacttgatta gaaaaagtgg atcttttcca atgccagagc ttaagctgtc   3060

aatttcattc cccaatatga catcaaatgg ttaccctgtg ctgtacccaa ctggattgtc   3120

atcttctgag aatgcaaact gcagacccca tatctttgag gatcctttca gtatcaactc   3180

tggaaagaaa atgactacat caactgacca tctcaaacga ggcacaattc tggactgcaa   3240

tacatgtaaa tttgctacca tcacatgtaa tctcacttct tctgacatca gccaagtcaa   3300

tgtttcgctt atcttgtgga aaccaacttt tataaaatca tatttttcca gcttaaatct   3360

tactataagg ggagaacttc ggagtgaaaa tgcatctctg gttttaagta gcagcaatca   3420

aaaaagagag cttgctattc aaatatccaa agatgggcta ccgggcagag tgccattatg   3480

ggtcatcctg ctgagtgctt ttgccggatt gttgctgtta atgctgctca ttttagcact   3540

gtggaagatt ggattcttca aaagaccact gaaaaagaaa atggagaaat gaaatatttt   3600

atgaaagaaa ataataacaa ttattcaata atctatcctc aggtttgcct caaatatgtg   3660

acaagaaatg tataattcat gacatagtca tgtaactatg taatccatca gggattcatt   3720

acttggaaaa tgacaggtca tgcattatcc aaaaacaata ccaaaaagac atattttata   3780

aaatgacaaa aaatatttta cataattact catttttgtt gagtaagcaa aattacaaag   3840

tgtttttaaa aaaacctgta caaatatgtt tatgtattaa atcaccatcc aaaatattta   3900

aggaatatat aaaaagattt ttatgatcat agaaacatct attttcaaaa caatataaat   3960

taagcttttc cccttgattc ctgttggata tccatgttca gcatgacagt cagcactcgt   4020

aaatgccaag aaaagaatta cctgaaaaag atcatttctc cctattcaaa tgagaatatt   4080

ttcccttggt agaatccata tacaatatgg attgaaaatt aagtcaccaa gaatacattt   4140

agcatctttg tgttgggttc tatacctaaa aattttccct ccctgcccaa ggtgattgga   4200

aagtactgca attgagctaa aattttatct aggatggaaa atcaggatag actcgtttaa   4260

aaacaagtat attaaatggg ttaaattaag cttttacaga acatgcttaa ttttgatatt   4320

gagctctaaa tgcaaaactc ttttatactg aaaaaacact taaagtagtt ttgtgtggca   4380

tcacagtgat ttgtcatgaa aagccatata tgggggacat gctaaaatgg cttctgaatg   4440

aaatacgaca gcagagaaag atgccactga aatgctgaaa ttatctttgc tgagcagctt   4500

ttgaatgcta agggttccag tatgtgaccc aaagaaagag ttgtctcaac tccttggtac   4560

agggttcatt caaaccccca agctgtgaga gtgtgtttat ttttaatttt ttaaaaggta   4620

tttaatttcc aaccacactt cttatttttt tgaaaagaca attttccatt tcagtattac   4680

attttaccaa gaagtcactg ctttttaggt gtgttgcatc aatatttaaa taaaatccca   4740

gaaatgtatt ttaaagaatt tcaggtttga aaactcaaac caacaggaag atatcaaaaa   4800

aaaaaaaaaa a                                                        4811


<210>  273
<211>  1179
<212>  PRT
<213>  Homo sapiens

<400>  273

Met Ala Pro Arg Pro Arg Ala Arg Pro Gly Val Ala Val Ala Cys Cys 
1               5                   10                  15


Trp Leu Leu Thr Val Val Leu Arg Cys Cys Val Ser Phe Asn Val Asp 
            20                  25                  30


Val Lys Asn Ser Met Thr Phe Ser Gly Pro Val Glu Asp Met Phe Gly 
        35                  40                  45


Tyr Thr Val Gln Gln Tyr Glu Asn Glu Glu Gly Lys Trp Val Leu Ile 
    50                  55                  60


Gly Ser Pro Leu Val Gly Gln Pro Lys Asn Arg Thr Gly Asp Val Tyr 
65                  70                  75                  80


Lys Cys Pro Val Gly Arg Gly Glu Ser Leu Pro Cys Val Lys Leu Asp 
                85                  90                  95


Leu Pro Val Asn Thr Ser Ile Pro Asn Val Thr Glu Val Lys Glu Asn 
            100                 105                 110


Met Thr Phe Gly Ser Thr Leu Val Thr Asn Pro Asn Gly Gly Phe Leu 
        115                 120                 125


Ala Cys Gly Pro Leu Tyr Ala Tyr Arg Cys Gly His Leu His Tyr Thr 
    130                 135                 140


Thr Gly Ile Cys Ser Asp Val Ser Pro Thr Phe Gln Val Val Asn Ser 
145                 150                 155                 160


Ile Ala Pro Val Gln Glu Cys Ser Thr Gln Leu Asp Ile Val Ile Val 
                165                 170                 175


Leu Asp Gly Ser Asn Ser Ile Tyr Pro Trp Asp Ser Val Thr Ala Phe 
            180                 185                 190


Leu Asn Asp Leu Leu Glu Arg Met Asp Ile Gly Pro Lys Gln Thr Gln 
        195                 200                 205


Val Gly Ile Val Gln Tyr Gly Glu Asn Val Thr His Glu Phe Asn Leu 
    210                 215                 220


Asn Lys Tyr Ser Ser Thr Glu Glu Val Leu Val Ala Ala Lys Lys Ile 
225                 230                 235                 240


Val Gln Arg Gly Gly Arg Gln Thr Met Thr Ala Leu Gly Ile Asp Thr 
                245                 250                 255


Ala Arg Lys Glu Ala Phe Thr Glu Ala Arg Gly Ala Arg Arg Gly Val 
            260                 265                 270


Lys Lys Val Met Val Ile Val Thr Asp Gly Glu Ser His Asp Asn His 
        275                 280                 285


Arg Leu Lys Lys Val Ile Gln Asp Cys Glu Asp Glu Asn Ile Gln Arg 
    290                 295                 300


Phe Ser Ile Ala Ile Leu Gly Ser Tyr Asn Arg Gly Asn Leu Ser Thr 
305                 310                 315                 320


Glu Lys Phe Val Glu Glu Ile Lys Ser Ile Ala Ser Glu Pro Thr Glu 
                325                 330                 335


Lys His Phe Phe Asn Val Ser Asp Glu Leu Ala Leu Val Thr Ile Val 
            340                 345                 350


Lys Thr Leu Gly Glu Arg Ile Phe Ala Leu Glu Ala Thr Ala Asp Gln 
        355                 360                 365


Ser Ala Ala Ser Phe Glu Met Glu Met Ser Gln Thr Gly Phe Ser Ala 
    370                 375                 380


His Tyr Ser Gln Asp Trp Val Met Leu Gly Ala Val Gly Ala Tyr Asp 
385                 390                 395                 400


Trp Asn Gly Thr Val Val Met Gln Lys Ala Ser Gln Ile Ile Ile Pro 
                405                 410                 415


Arg Asn Thr Thr Phe Asn Val Glu Ser Thr Lys Lys Asn Glu Pro Leu 
            420                 425                 430


Ala Ser Tyr Leu Gly Tyr Thr Val Asn Ser Ala Thr Ala Ser Ser Gly 
        435                 440                 445


Asp Val Leu Tyr Ile Ala Gly Gln Pro Arg Tyr Asn His Thr Gly Gln 
    450                 455                 460


Val Ile Ile Tyr Arg Met Glu Asp Gly Asn Ile Lys Ile Leu Gln Thr 
465                 470                 475                 480


Leu Ser Gly Glu Gln Ile Gly Ser Tyr Phe Gly Ser Ile Leu Thr Thr 
                485                 490                 495


Thr Asp Ile Asp Lys Asp Ser Asn Thr Asp Ile Leu Leu Val Gly Ala 
            500                 505                 510


Pro Met Tyr Met Gly Thr Glu Lys Glu Glu Gln Gly Lys Val Tyr Val 
        515                 520                 525


Tyr Ala Leu Asn Gln Thr Arg Phe Glu Tyr Gln Met Ser Leu Glu Pro 
    530                 535                 540


Ile Lys Gln Thr Cys Cys Ser Ser Arg Gln His Asn Ser Cys Thr Thr 
545                 550                 555                 560


Glu Asn Lys Asn Glu Pro Cys Gly Ala Arg Phe Gly Thr Ala Ile Ala 
                565                 570                 575


Ala Val Lys Asp Leu Asn Leu Asp Gly Phe Asn Asp Ile Val Ile Gly 
            580                 585                 590


Ala Pro Leu Glu Asp Asp His Gly Gly Ala Val Tyr Ile Tyr His Gly 
        595                 600                 605


Ser Gly Lys Thr Ile Arg Lys Glu Tyr Ala Gln Arg Ile Pro Ser Gly 
    610                 615                 620


Gly Asp Gly Lys Thr Leu Lys Phe Phe Gly Gln Ser Ile His Gly Glu 
625                 630                 635                 640


Met Asp Leu Asn Gly Asp Gly Leu Thr Asp Val Thr Ile Gly Gly Leu 
                645                 650                 655


Gly Gly Ala Ala Leu Phe Trp Ser Arg Asp Val Ala Val Val Lys Val 
            660                 665                 670


Thr Met Asn Phe Glu Pro Asn Lys Val Asn Ile Gln Lys Lys Asn Cys 
        675                 680                 685


His Met Glu Gly Lys Glu Thr Val Cys Ile Asn Ala Thr Val Cys Phe 
    690                 695                 700


Asp Val Lys Leu Lys Ser Lys Glu Asp Thr Ile Tyr Glu Ala Asp Leu 
705                 710                 715                 720


Gln Tyr Arg Val Thr Leu Asp Ser Leu Arg Gln Ile Ser Arg Ser Phe 
                725                 730                 735


Phe Ser Gly Thr Gln Glu Arg Lys Val Gln Arg Asn Ile Thr Val Arg 
            740                 745                 750


Lys Ser Glu Cys Thr Lys His Ser Phe Tyr Met Leu Asp Lys His Asp 
        755                 760                 765


Phe Gln Asp Ser Val Arg Ile Thr Leu Asp Phe Asn Leu Thr Asp Pro 
    770                 775                 780


Glu Asn Gly Pro Val Leu Asp Asp Ser Leu Pro Asn Ser Val His Glu 
785                 790                 795                 800


Tyr Ile Pro Phe Ala Lys Asp Cys Gly Asn Lys Glu Lys Cys Ile Ser 
                805                 810                 815


Asp Leu Ser Leu His Val Ala Thr Thr Glu Lys Asp Leu Leu Ile Val 
            820                 825                 830


Arg Ser Gln Asn Asp Lys Phe Asn Val Ser Leu Thr Val Lys Asn Thr 
        835                 840                 845


Lys Asp Ser Ala Tyr Asn Thr Arg Thr Ile Val His Tyr Ser Pro Asn 
    850                 855                 860


Leu Val Phe Ser Gly Ile Glu Ala Ile Gln Lys Asp Ser Cys Glu Ser 
865                 870                 875                 880


Asn His Asn Ile Thr Cys Lys Val Gly Tyr Pro Phe Leu Arg Arg Gly 
                885                 890                 895


Glu Met Val Thr Phe Lys Ile Leu Phe Gln Phe Asn Thr Ser Tyr Leu 
            900                 905                 910


Met Glu Asn Val Thr Ile Tyr Leu Ser Ala Thr Ser Asp Ser Glu Glu 
        915                 920                 925


Pro Pro Glu Thr Leu Ser Asp Asn Val Val Asn Ile Ser Ile Pro Val 
    930                 935                 940


Lys Tyr Glu Val Gly Leu Gln Phe Tyr Ser Ser Ala Ser Glu Tyr His 
945                 950                 955                 960


Ile Ser Ile Ala Ala Asn Glu Thr Val Pro Glu Val Ile Asn Ser Thr 
                965                 970                 975


Glu Asp Ile Gly Asn Glu Ile Asn Ile Phe Tyr Leu Ile Arg Lys Ser 
            980                 985                 990


Gly Ser Phe Pro Met Pro Glu Leu Lys Leu Ser Ile Ser Phe Pro Asn 
        995                 1000                1005


Met Thr Ser Asn Gly Tyr Pro Val Leu Tyr Pro Thr Gly Leu Ser Ser 
    1010                1015                1020


Ser Glu Asn Ala Asn Cys Arg Pro His Ile Phe Glu Asp Pro Phe Ser 
1025                1030                1035                1040


Ile Asn Ser Gly Lys Lys Met Thr Thr Ser Thr Asp His Leu Lys Arg 
                1045                1050                1055


Gly Thr Ile Leu Asp Cys Asn Thr Cys Lys Phe Ala Thr Ile Thr Cys 
            1060                1065                1070


Asn Leu Thr Ser Ser Asp Ile Ser Gln Val Asn Val Ser Leu Ile Leu 
        1075                1080                1085


Trp Lys Pro Thr Phe Ile Lys Ser Tyr Phe Ser Ser Leu Asn Leu Thr 
    1090                1095                1100


Ile Arg Gly Glu Leu Arg Ser Glu Asn Ala Ser Leu Val Leu Ser Ser 
1105                1110                1115                1120


Ser Asn Gln Lys Arg Glu Leu Ala Ile Gln Ile Ser Lys Asp Gly Leu 
                1125                1130                1135


Pro Gly Arg Val Pro Leu Trp Val Ile Leu Leu Ser Ala Phe Ala Gly 
            1140                1145                1150


Leu Leu Leu Leu Met Leu Leu Ile Leu Ala Leu Trp Lys Ile Gly Phe 
        1155                1160                1165


Phe Lys Arg Pro Leu Lys Lys Lys Met Glu Lys 
    1170                1175


<210>  274
<211>  997
<212>  DNA
<213>  Homo sapiens

<400>  274
atgttgtggg aggtccctga ggccgctgag gtcgttcgtg tctgttgaac ggctgtgggc     60

gtcttgctgc cttgggtagg gggttaaaat cgttcttgag aggaacgtct ctgtgcgaag    120

agataatgag tttagctctg agaagtgagc ttgtagtgga caaaacaaag aggaaaaaaa    180

gaagagaact gtctgaggaa cagaaacaag aaattaaaga tgcttttgaa ctatttgata    240

cagacaaaga tgaagcaata gattatcatg aattaaaggt ggcaatgaga gccttggggt    300

ttgatgtaaa aaaagctgat gtactgaaga ttcttaaaga ttatgacaga gaagccacag    360

ggaaaatcac ctttgaagat tttaatgaag ttgtgacaga ctggatattg gaaagagatc    420

cccatgaaga aatactcaag gcatttaaac tatttgatga tgatgattca ggtaaaataa    480

gcttgaggaa tttgcgacgt gttgctagag aattgggtga aaacatgagt gatgaagaac    540

ttcgagctat gatagaagaa tttgacaaag atggtgatgg agaaataaac caagaggagt    600

tcattgctat tatgactggt gacatttaaa gaattacaag gataaacact aagaatgttg    660

cagttaccat cttatattct atttttgtgc ctggagccat gtgaaaaaaa ccaacttagt    720

tcttttatcc taaaggacca aaaataagca tcttatatat ctgtatttta ctactgttaa    780

gtttctttgt atgaactgtg ttgttagtac tcagatagtt tagctttgta tttataatag    840

agcttttata taaagtttta aaaattgaat gtgtgatatg tgttctttga aggtttttta    900

atttaacatt tatagtcact ttttagtgca cacattttcc agactttcgt taataaaata    960

tttattttat tagaatttta aaaaaaaaaa aaaaaaa                             997


<210>  275
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  275

Met Ser Leu Ala Leu Arg Ser Glu Leu Val Val Asp Lys Thr Lys Arg 
1               5                   10                  15


Lys Lys Arg Arg Glu Leu Ser Glu Glu Gln Lys Gln Glu Ile Lys Asp 
            20                  25                  30


Ala Phe Glu Leu Phe Asp Thr Asp Lys Asp Glu Ala Ile Asp Tyr His 
        35                  40                  45


Glu Leu Lys Val Ala Met Arg Ala Leu Gly Phe Asp Val Lys Lys Ala 
    50                  55                  60


Asp Val Leu Lys Ile Leu Lys Asp Tyr Asp Arg Glu Ala Thr Gly Lys 
65                  70                  75                  80


Ile Thr Phe Glu Asp Phe Asn Glu Val Val Thr Asp Trp Ile Leu Glu 
                85                  90                  95


Arg Asp Pro His Glu Glu Ile Leu Lys Ala Phe Lys Leu Phe Asp Asp 
            100                 105                 110


Asp Asp Ser Gly Lys Ile Ser Leu Arg Asn Leu Arg Arg Val Ala Arg 
        115                 120                 125


Glu Leu Gly Glu Asn Met Ser Asp Glu Glu Leu Arg Ala Met Ile Glu 
    130                 135                 140


Glu Phe Asp Lys Asp Gly Asp Gly Glu Ile Asn Gln Glu Glu Phe Ile 
145                 150                 155                 160


Ala Ile Met Thr Gly Asp Ile 
                165


<210>  276
<211>  4300
<212>  DNA
<213>  Homo sapiens

<400>  276
caacccgcga ggccccacac tttctgcgcc agctgggagt gcgcgccctg cagagccagt     60

gggtgggcgg ttctagctct tcccaccctc actgcgggcc tctgctgtca cacgcccggg    120

gtggcgaaac ggtcgccacc tgagtctcca ttctgctgca gtggcccctg cgttaaagct    180

ctctcgtggt gcggctgccg aggctgcggt agctcctgcg cccccgtgct ggtggcgcag    240

cctctgcttg ctgccgacct ggcggaaggg tgcgggagcg cacgctacgg gcagcgtcgg    300

tctgcgtcct tcctcctcct attccgaccc ccgcatccca cgcccccgcc tcgctctacg    360

cctcctccct ggctgcaggc agaccgcttc acacagccgc agtgccctgt gtgtggacag    420

cctgtgggag actcgcacgc ccacactcac cccgcctggc tgcacccctg cccagcatgt    480

cggcgctcga gtggtacgcc cacaagtctc taggcgatgg tatcttctgg attcaagaac    540

gtttctacga gtcgggcaac cgtgccaaca tctggctggt gcgcggctcc gagcaggacg    600

tggtgatcga tacaggcctg gggctgcgca gcctcccgga gtacctgtac tcctccggcc    660

tcttgcagga ccgagaggcc aaagaggacg cggcgcgccg gccactgctt gccgtggcca    720

cccacgtgca cttcgaccac tccggcggcc tctaccagtt cgaccgcgtg gcagtgcacc    780

acgccgaggc cgaggcgctg gctcgcgggg acaactttga gaccgtgacc tggctttccg    840

atagcgaggt ggtgcgggcg cccagccccg gctggagggc cagacagttc cgggtacagg    900

cggtgcagcc caccctcatc ctgcaggatg gggatgtgat caaccttggt gacagacagc    960

tcactgttat gcacatgcca ggtcactcca ggggcagtat ttgcttacat gacaaagacc   1020

gaaagattct cttcagtgga gacgtcgtgt atgatggatc actgattgac tggctcccat   1080

acagcaggat aagtgactat gttggaactt gtgaacgtct aatagaatta gtggacagag   1140

gtctggtaga gaaggtgctt cctgggcact tcaatacctt tggtgctgaa aggctttttc   1200

gattggcttc taactatatt tcaaaagctg ggatatgtca caaagtttct acttttgcca   1260

tgcgatctct tgcaagttta gctctacgtg taacaaattc taggacctcg ccctagtatc   1320

tatactgata atatattttg attaattata tacattaatt cattctgtgc tatttaactg   1380

attaatagtg agcatttcat gaagtgcttt tataccacta ttatatatca gagaaagatt   1440

gagaatgaat aagccaaaaa gaaaattgtt agtttaaatt gttttctttc ttccaagaaa   1500

gaagccactt aaataagctt atactttgcc aaagctgtca tcttgtaata tatgctctag   1560

aaatgacata aaggtttatg gggaagcaaa gagagatttt gtggcaagag aactgccctt   1620

gcctctgttt ttcttgtttt attcccttga tgacctaggg aaaaaaaggc atgtagagta   1680

ttatgtttat actttaaact tgatattttt agtgtattat ttaaagataa aggttcttgg   1740

gtttaaaata cattagaact taatgcagac atataaagta acattgagaa tgacaactaa   1800

aacattccat tgttatggtc ctgaattttt tatgcttcat ttcatgtatt tattctttgt   1860

ataattatag catacatgtt atgtaatata acttatgaaa agtacagtga attttgcttt   1920

attgcaaagc tttaaatata aatttcagag tgcttcagta aaaagctact atatattgtt   1980

gtttgttatt gtgtaggtaa tattttcaat tatgaaagtg aaatgcaaat gtctgttatc   2040

taactacaaa ttgtcagatt tcttaaaagg acactgtcag gcaaatttga aaatatacac   2100

attgagaata attttttatt attatatcct attttaatat taacagctat tatgaacaaa   2160

atttttcctg ttaaatagcg acttcagtat tgtgttatgt tttacagcgt taaaacaact   2220

atgaagatct gcagctattc ttttacttaa catgcatatg tactacagag ggatttttaa   2280

attaattgca aaatgtgcat tagctattga cttagagtga attgcctttt gtatcctgat   2340

tcacaacacc tattcctgtt cagtattctt tgtcttgaat agagaagtct atgttcgtaa   2400

agtcatataa aaggttatac cactatttag taaaaagttt tagtttggtg ctgttaataa   2460

taatttgcta aaaggccttt tagaatattt cataaagggt tttaaacagt tttttcccac   2520

tgccttttta ttattgacat atctaaaacc aaactgaaat cgctttggaa atcagatttt   2580

ttaatgttag gaagatccag caattttggt ttctgaaaaa ttacaaaact tttctaccct   2640

acagatgccc aggttcttta gttttttatt cattcaactc acacacacat aaacatatac   2700

atacacaaac acaatcccac atgcaaacac acacagccac atatatacat gtgtagcaca   2760

gcgctaaaca ctgtggaggc taaaaaaagt caaagacaac attataacta aaagtcgaaa   2820

gcacacaaaa tataaataat agtgtatgca agttaatgta cattatacat gcgtgtaagg   2880

gacataaatg gaggggtgtg aactttggtt aggcaaagtt tactggagga ggggtttttg   2940

agtcaaattt ggaaggatga acttgttaga tagtcagagt tggaaacaaa acaatccaag   3000

aatagggata taagcattgc tagtctagaa tagtctattc cttgtgaaaa tataaattta   3060

attttcagga atccagtata ttccaaacat cacatattta gcatgagaaa aattgatttg   3120

tgattgtgta tatgagtcat tgttaatggg agacaagctg aactgccaca tgccaccaaa   3180

tgaaccttta cttcaatcaa aaaggagggt atgattggtt caattatatt aacagaatat   3240

catgggcatt tctctatgat ggtcattcaa ggtagtaggt ctctttcaac tgagtgcaac   3300

attgagaata atgatttggt tcagggcaac tacaaataat cacttactaa gccttaaata   3360

aagccattat ttttatatca atagcacaaa ggaaaaccaa aagtccttaa ccactgacca   3420

tttttatcat attttaggcc tttttttaaa aaatcagggt atagtaggca ctaagtttta   3480

ttaggaaata tttaaacctg ctgaaggatt tatttataaa aagtgcaatt tttcaaaaca   3540

cattattatt ttttaatttc ccaatttttt cagtttttca aattgtacca caacatagaa   3600

ctgtgatatt ttgctattac ttcaatgtga ataaataagg taaagtatat catttattga   3660

gtgcccatgc tgtacattta aaatatgcat tatttaattt aatcttactc ccagcaccaa   3720

aaggtaattg accagcctca acacaatttt ggacaaagct agtaactgaa cacaggtctg   3780

tctgccccac acttctcttt ctcttgtaac tgcacaatag cagaaaattg gcaagatgta   3840

tttttacttt ccaagatgcc gtgtgtgcca agaataaatg aaatgatgtt aaagcataat   3900

aataacatat ctttaaaaag cttttcaaaa tatattttca ccctgacagt gacccttgta   3960

acttaaatga tttttggaaa tattagtatg taagtataat tcaaagttgt caaaatgtaa   4020

gacatttaga agtaattttt attatttata ttgttaatac ttaatcactg gaaattcatt   4080

ttccttactc gatgttttct ttcaactgag aagcctaaaa caaacaaaaa ccttgtgtgt   4140

tatcctgata tagttgacta aatgtatttg ttcttatatg gatagtaata tgaatgtgac   4200

atgcaccaat tgtcctatta taattttcag ataagtgtaa ctaagcactt gtgtaataaa   4260

tattagtcat tttatttcaa aaaaaaaaaa aaaaaaaaaa                         4300


<210>  277
<211>  279
<212>  PRT
<213>  Homo sapiens

<400>  277

Met Ser Ala Leu Glu Trp Tyr Ala His Lys Ser Leu Gly Asp Gly Ile 
1               5                   10                  15


Phe Trp Ile Gln Glu Arg Phe Tyr Glu Ser Gly Asn Arg Ala Asn Ile 
            20                  25                  30


Trp Leu Val Arg Gly Ser Glu Gln Asp Val Val Ile Asp Thr Gly Leu 
        35                  40                  45


Gly Leu Arg Ser Leu Pro Glu Tyr Leu Tyr Ser Ser Gly Leu Leu Gln 
    50                  55                  60


Asp Arg Glu Ala Lys Glu Asp Ala Ala Arg Arg Pro Leu Leu Ala Val 
65                  70                  75                  80


Ala Thr His Val His Phe Asp His Ser Gly Gly Leu Tyr Gln Phe Asp 
                85                  90                  95


Arg Val Ala Val His His Ala Glu Ala Glu Ala Leu Ala Arg Gly Asp 
            100                 105                 110


Asn Phe Glu Thr Val Thr Trp Leu Ser Asp Ser Glu Val Val Arg Ala 
        115                 120                 125


Pro Ser Pro Gly Trp Arg Ala Arg Gln Phe Arg Val Gln Ala Val Gln 
    130                 135                 140


Pro Thr Leu Ile Leu Gln Asp Gly Asp Val Ile Asn Leu Gly Asp Arg 
145                 150                 155                 160


Gln Leu Thr Val Met His Met Pro Gly His Ser Arg Gly Ser Ile Cys 
                165                 170                 175


Leu His Asp Lys Asp Arg Lys Ile Leu Phe Ser Gly Asp Val Val Tyr 
            180                 185                 190


Asp Gly Ser Leu Ile Asp Trp Leu Pro Tyr Ser Arg Ile Ser Asp Tyr 
        195                 200                 205


Val Gly Thr Cys Glu Arg Leu Ile Glu Leu Val Asp Arg Gly Leu Val 
    210                 215                 220


Glu Lys Val Leu Pro Gly His Phe Asn Thr Phe Gly Ala Glu Arg Leu 
225                 230                 235                 240


Phe Arg Leu Ala Ser Asn Tyr Ile Ser Lys Ala Gly Ile Cys His Lys 
                245                 250                 255


Val Ser Thr Phe Ala Met Arg Ser Leu Ala Ser Leu Ala Leu Arg Val 
            260                 265                 270


Thr Asn Ser Arg Thr Ser Pro 
        275


<210>  278
<211>  3285
<212>  DNA
<213>  Homo sapiens

<400>  278
actccgcggt cctggtgccg cgtgcaggtc ggtgcgcgct tctcccgagg tggaacgggc     60

ggcagtcaag cgccggcgtt ctctgccgtc accctttcct tgccggccgg cacttcggct    120

gcagagtttt gcccacgctt cgagacttag ggagcagtgc ctttcagaat ttgcccactc    180

atctggtata actggttctg atggctggga ataaaggaag aggacgtgct gcttatacct    240

ttaatattga ggctgttgga tttagcaaag gtgaaaagtt acctgatgta gtgttgaaac    300

cacccccact atttcctgat acagattata aaccagtgcc actgaaaaca ggagaaggtg    360

aagaatatat gctggctttg aaacaggagt tgagagaaac aatgaaaaga atgccttatt    420

ttattgaaac acctgaagaa agacaagata ttgaaaggta tagtaaaaga tacatgaagg    480

tatacaagga agaatggata ccagattgga gaagacttcc aagagagatg atgccaagaa    540

ataaatgtaa aaaagcaggc ccaaaaccca aaaaggcaaa agacgcaggc aaaggcacac    600

cactcactaa tactgaagat gtgttgaaaa aaatggagga attggaaaaa agaggtgatg    660

gtgaaaaatc agatgaggaa aatgaagaga aagaaggaag caaagagaaa agtaaagaag    720

gtgatgatga cgatgacgat gatgccgcag aacaggagga atatgatgaa gaagagcaag    780

aagaggaaaa tgactacatt aattcatact ttgaagatgg agatgatttt ggcgcagaca    840

gtgatgacaa catggatgag gcaacctatt aggcatgaaa tttttcaaaa aatattttta    900

tgatgcagct tctgaacatt tggacagact tgatttgtat tttatttctg ataaggaata    960

agtacttgtt tctgttgttt tggacaaata gttgttacca aaatattcaa aaccactttg   1020

agtttacata ctagttacct taaaaattat tccctgacac tctgacattc cttctaaaca   1080

cctctgccat ctctcttatg tactctcatg ggtttttttg tatgatttga atatgaatgt   1140

gcctaaagaa tttttgctct cttaatctat gtatacatac ttgaacaaat cattcttgct   1200

taactgctga tcttttgtaa aactattgct agtcataatg gatttctata acctgaaagt   1260

tgatataata cagcacgtgg agcactttaa aaacaaagaa acttgaaaat aattttattt   1320

tttaccttta catggtgtgt tctagactac tgcattatga ctacataaac ctacctgagc   1380

tcttacaagt acagaattgt gagacagagg ttttgtgatg gaaaacatac acatagggaa   1440

aaataccaaa ctgagcaata taaatttcac agctcacatc ttagccagta caaagaaact   1500

ttcacatggg gtgaatatta taatacttga atttgagact taatactgta tatgaattaa   1560

tcatcccact gtaataactg acatcttcaa atagttgggc ttatgaaaaa tttgactaag   1620

acattttatt ttatacttta tgtaaatgtg aaataagttc tggtcatata aatatgtaga   1680

atgcatgtgt gtgaactcta tgaagtgaag tgtggtggcc ttttatgttt cagagtactc   1740

aagtgtacaa ttgatttata taaaaatgca aaatgaactc aggtcatttt gaaattaata   1800

ttaatatttt tgttgtttaa ctttaaagct agctccccta actttatata ttttttggga   1860

aaaaatacct aaaaacctca gcctacaaag actctcagaa atgccaaaga ttttcaagga   1920

aattcatatt atatatttca aaaatgattt atcaatgtta tctaccaaaa gaaataattt   1980

tatttttccc ctttggggag atattatcct ctaatatgag aatcagatcc ctagattcta   2040

tttctaccta tactattaaa ctcaaccttg aacctgagct tggttgtttc tgtgccttag   2100

tttctccact cgtaaacaat ttcctataaa aattgtttaa acaccaacca aaatttacca   2160

tatgtattca ttctcttgcc ttaaagatca cttcttaact tacatttggc tctcaccctc   2220

taaaaatttg tagtttggag agtaactgaa agcacaattt taagaaacat gttttcctca   2280

caaaatatat tgtaatctga ttttcctatc ttgtattcat gcagaaaatt ggagaaaatg   2340

tgtattgtct tgtgccattc tgcaatatga atttctcagg aaaaagatgt ttcaatggca   2400

atactttctt aaataattca agatgggtgt gaggacctat cttattagtt tagtgctgtg   2460

ttaaccattt gtgaattact tcttgtttaa aggaagttgt caaaaaattt taagattcta   2520

aatggaatac acgaataaag taagccttag aatagaaacc tcacaaaaag ttgtcatttg   2580

cggttgataa ttaacatagg tgttttattc tctcaactcc ttagtaccag agccaaatac   2640

aatttagttt tcagaaatct tatcaatatt gttctattta cctacttata aatctgcaga   2700

taaccacttg aaccaggcaa atacactgaa gataaaggtt atttcttttt ttagctttga   2760

atttgtcatg accattttag tcttgcagat agcagggcag ccccttgggg caaggattta   2820

ctctgggagg taccgttaag agccttcttt ccccctttga aagatccttt tacaatgtta   2880

aagtatacta gttgcaagaa caagcaggat ttgcaggttg ctttaccagc atgagtctca   2940

tttttctggc ttaaaatctg ggactgtgaa attattccat aggaaagtga atgttatttt   3000

gcagaattag cctcttacat aaaagtattt gttgaagtgt ctttaaaatt gctatcatga   3060

gcaaaactgg ttgctgtaat gcttgttttt ctgtatttat ttacacatta aattcttaca   3120

aaacaaaatg tgttcgtttg ttttatagta agatgtttta ttttgaactt atttaaatgt   3180

ttatttgtta gagaaaacta atttgttaat atagatctta actagtaact attaagcagg   3240

gatgtttgtt ccaaatattc ttgaataaac aatcaccaca aacaa                   3285


<210>  279
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  279

Met Ala Gly Asn Lys Gly Arg Gly Arg Ala Ala Tyr Thr Phe Asn Ile 
1               5                   10                  15


Glu Ala Val Gly Phe Ser Lys Gly Glu Lys Leu Pro Asp Val Val Leu 
            20                  25                  30


Lys Pro Pro Pro Leu Phe Pro Asp Thr Asp Tyr Lys Pro Val Pro Leu 
        35                  40                  45


Lys Thr Gly Glu Gly Glu Glu Tyr Met Leu Ala Leu Lys Gln Glu Leu 
    50                  55                  60


Arg Glu Thr Met Lys Arg Met Pro Tyr Phe Ile Glu Thr Pro Glu Glu 
65                  70                  75                  80


Arg Gln Asp Ile Glu Arg Tyr Ser Lys Arg Tyr Met Lys Val Tyr Lys 
                85                  90                  95


Glu Glu Trp Ile Pro Asp Trp Arg Arg Leu Pro Arg Glu Met Met Pro 
            100                 105                 110


Arg Asn Lys Cys Lys Lys Ala Gly Pro Lys Pro Lys Lys Ala Lys Asp 
        115                 120                 125


Ala Gly Lys Gly Thr Pro Leu Thr Asn Thr Glu Asp Val Leu Lys Lys 
    130                 135                 140


Met Glu Glu Leu Glu Lys Arg Gly Asp Gly Glu Lys Ser Asp Glu Glu 
145                 150                 155                 160


Asn Glu Glu Lys Glu Gly Ser Lys Glu Lys Ser Lys Glu Gly Asp Asp 
                165                 170                 175


Asp Asp Asp Asp Asp Ala Ala Glu Gln Glu Glu Tyr Asp Glu Glu Glu 
            180                 185                 190


Gln Glu Glu Glu Asn Asp Tyr Ile Asn Ser Tyr Phe Glu Asp Gly Asp 
        195                 200                 205


Asp Phe Gly Ala Asp Ser Asp Asp Asn Met Asp Glu Ala Thr Tyr 
    210                 215                 220


<210>  280
<211>  6457
<212>  DNA
<213>  Homo sapiens

<400>  280
gtgaatcaaa ggagagtccc agaaaacctg tgactgttga agaaaattca tctgtgaatt     60

tttatattca aggagtcagt atttatattc atcttttaaa ctgggaagat ttatatttta    120

ctttaaaact tcttgataat aatttacaat gaatggacac agtgatgaag aaagtgttag    180

aaacagtagt ggagaatcaa gccagtcgga tgatgattct gggtcagctt caggctctgg    240

atctggttcg agttctggaa gcagtagtga tggaagcagt agccagtcag gtagcagtga    300

ctctgactcc ggatctgaat caggcagtca gtcagagtct gagtcagaca cttcccgaga    360

aaacaaagtt caagcaaaac caccgaaagt tgatggagct gagttttgga aatctagtcc    420

tagtattctg gccgttcaga gatctgcaat cctcaagaag cagcaacagc agcagcagca    480

acaacaacat caagcctcat ctaatagcgg atcagaagag gattcctcta gcagtgaaga    540

ttccgatgac tcatcaagtg aggtcaaaag gaaaaagcat aaagatgaag attggcaaat    600

gtctgggtca ggatctccat ctcagtctgg ttcagattca gaatctgaag aagagagaga    660

gaaaagcagt tgtgatgaaa cagaatctga ttatgagcca aaaaacaaag tcaaaagcag    720

aaaacctcaa aatagatcta agtcaaaaaa tggaaagaag attcttggac aaaaaaagag    780

acagattgat tcatctgagg aggatgatga tgaagaagat tatgataatg ataaaagaag    840

ttctcgtcgc caagcaactg ttaatgttag ctataaggag gatgaagaaa tgaaaacaga    900

ttctgatgac ctactggaag tctgtggaga ggatgttcct caacctgagg aagaggaatt    960

tgaaaccata gaaagattta tggattgtcg gattgggaga aaaggagcta ctggtgctac   1020

tacaaccatc tatgcagttg aagcagatgg tgacccaaat gcaggctttg aaaaaaacaa   1080

agaaccagga gagattcagt atttaattaa atggaaagga tggtcccata tccacaacac   1140

ttgggagaca gaagaaaccc tcaagcagca gaatgttaga ggaatgaaaa aattggataa   1200

ttataagaaa aaagatcagg aaacaaaaag atggttgaaa aatgcctctc cagaagatgt   1260

ggaatattat aattgccagc aagaacttac agatgatcta cataaacagt atcaaatagt   1320

ggaacgtata attgctcatt ccaatcaaaa gtcagcagct ggttatcctg attattactg   1380

caaatggcag ggccttccat actcagagtg cagctgggaa gatggagctc tcatttccaa   1440

aaagtttcaa gcatgcattg atgagtattt tagcaggaac caatcaaaaa ccactccttt   1500

taaagattgc aaagtattaa aacaaaggcc aaggtttgta gccctgaaga agcagccatc   1560

ctatattgga ggacatgagg gcttagaatt aagagattat caactgaatg gtttaaattg   1620

gcttgctcat tcttggtgca aaggaaatag ttgcatactc gctgatgaaa tgggccttgg   1680

aaaaacaata cagacgatct catttctgaa ttatttgttt catgaacatc aattatatgg   1740

acctttttta ttggtagtac cgctctccac tcttacttcc tggcaaaggg aaattcagac   1800

ttgggcttct caaatgaatg ctgtggttta tttaggtgac attaacagca gaaacatgat   1860

aagaactcat gaatggacgc atcatcagac caaacggtta aaatttaata tattgttaac   1920

aacttatgaa attttattaa aagataaggc attccttgga ggtctaaatt gggcatttat   1980

aggtgttgat gaagcacacc gattaaagaa tgatgactcc cttctgtata aaactttaat   2040

agattttaaa tccaatcatc gtctccttat cactggaact cctctacaga attccctcaa   2100

agagctctgg tctttgctac atttcattat gccagaaaag ttttcttcct gggaagattt   2160

tgaagaagaa catggcaaag ggagagaata tggttatgca agccttcaca aggagcttga   2220

gccatttctg ttacgccgag ttaagaaaga tgtggaaaaa tctcttcctg ccaaggttga   2280

gcagatttta agaatggaaa tgagtgcttt acagaaacaa tattacaaat ggattttaac   2340

taggaattac aaagccctca gcaaaggttc caagggcagt acctcaggct ttttgaacat   2400

tatgatggag ctaaagaaat gttgtaacca ttgctacctc attaaaccac cagataataa   2460

tgaattctat aataaacagg aggccttaca acacttaatt cgtagtagcg gaaaattgat   2520

tcttcttgac aagctattaa ttcgcctaag agaacgaggc aatcgagttc ttattttttc   2580

acaaatggtg cggatgttag atatacttgc agaatatttg aaatatcgtc aattcccctt   2640

tcaaagatta gatggatcaa taaaaggaga actgaggaaa caagctctag atcattttaa   2700

tgctgaggga tcagaggatt tttgcttttt gctgtccaca agagctggag gtctagggat   2760

taatttagcc tctgctgaca ctgttgttat atttgattcc gattggaatc cacagaatga   2820

tcttcaggca caggctagag cccatcgaat tgggcaaaag aaacaggtga atatttatcg   2880

tctagttaca aagggatcag ttgaagaaga tattcttgaa agggcgaaaa agaagatggt   2940

tttagatcat cttgtaattc aaagaatgga cacaactggg aagacagtac tacatacagg   3000

ttctgcccca tcaagttcta ctcctttcaa taaagaagag ttatcagcca ttttaaagtt   3060

tggtgctgaa gaacttttta aggaacctga aggagaagaa caagagcccc aggaaatgga   3120

tatagatgaa atcttgaaga gagctgaaac tcatgaaaat gaaccaggtc ctttaactgt   3180

aggagatgaa ttgctttccc agttcaaggt tgccaacttc tcaaatatgg atgaggatga   3240

cattgagttg gaacctgaaa gaaattcaaa gaattgggag gaaattattc cagaagatca   3300

aagaagacga ttagaagaag aagaaagaca aaaggaactt gaagaaattt atatgctccc   3360

aagaatgaga aattgtgcaa aacagattag tttcaatgga agtgaaggga ggcgcagtag   3420

aagtaggaga tactctggat ctgatagtga ttccatctca gaagggaaaa ggccaaagaa   3480

acgtggaaga ccacggacta ttcctcggga gaatattaaa ggatttagtg atgcagaaat   3540

taggcggttt atcaagagct ataagaaatt tggtggtcct ctggaaagat tagatgcaat   3600

tgctcgagat gctgagttag ttgataagtc agaaacagac cttagacgac tgggagaatt   3660

ggtacataat ggttgcatta aagcattaaa ggatagttct tcaggaacag aacgaacagg   3720

tggtagactc ggaaaagtga agggtccaac attccgaata tcaggagtac aggtgaatgc   3780

caaactagtc atctcccatg aagaagaatt aatacctttg cacaaatcca ttccttctga   3840

tccagaagaa agaaagcagt atactatccc atgccacaca aaggcagctc attttgatat   3900

agactggggc aaagaagatg attccaattt gttaattggc atctatgaat atggatatgg   3960

aagctgggaa atgattaaaa tggatcctga cctcagtcta acacacaaga ttcttccaga   4020

tgatcccgat aaaaaaccac aagcaaaaca gttgcagacc cgtgcagact acctcatcaa   4080

attacttagt agagatcttg caaaaaaaga agctctttct ggtgcgggaa gttcaaagag   4140

gagaaaagca agagctaaga agaataaagc aatgaagtct ataaaagtga aagaggaaat   4200

aaagagtgat tcttctcctc tgccttcaga gaagtctgat gaagatgatg ataaattgag   4260

tgaatccaag tctgatggta gggaaagatc caagaaatct tcagtgtcag atgctccagt   4320

tcatatcacg gcaagtggtg aaccagttcc catttctgaa gaatctgaag agctggatca   4380

gaagacattc agcatttgta aagaaagaat gaggcctgtt aaagcagctt tgaaacaact   4440

tgataggcct gagaaaggcc tttcagaaag agaacaacta gagcatacta gacaatgttt   4500

aataaaaatt ggagaccata tcacagaatg tctaaaagag tatacaaatc ctgaacaaat   4560

taagcaatgg agaaaaaacc tgtggatttt tgtatctaag tttactgaat ttgatgcaag   4620

aaaattacat aaattatata agcatgctat taaaaaacgg caggagtctc agcaaaacag   4680

tgatcaaaac agcaacttga atcctcacgt gattagaaat ccagatgtgg aaagattaaa   4740

agagaataca aatcacgatg atagcagcag ggacagttat tcctctgata gacacttaac   4800

tcagtaccat gatcatcata aagaccgaca tcagggagat tcttacaaaa aaagtgattc   4860

caggaaaaga ccctattctt cttttagtaa tggtaaagac catcgtgatt gggatcacta   4920

caagcaagac agcagatatt acagtgacag agagaaacac agaaaactgg atgatcacag   4980

gagtagagat cacaggtcaa atttggaagg aagtttaaaa gatagatctc attctgatca   5040

tcgttctcac tcagatcatc ggttacattc agaccaccgg tcaagttctg aatatacgca   5100

ccataaatct tccagggatt ataggtatca ctcagactgg caaatggacc acagagcttc   5160

cagcagtggc cctaggtcac cactagatca gagatctcct tatggctcca gatctccatt   5220

tgaacattca gttgaacaca aaagtacacc ggagcatacc tggagtagtc ggaaaacata   5280

acaaaaactg atacttcgtc tttctggact tttcttttag ccatatatca taaaccaaca   5340

cagtaattgc cttacatgac ttgaaagata taaacagatc ttctatcagt agcagtattg   5400

ttacttcttt ccaggatgca aggtctatta tcccaacaga agagaaaata tttttatatt   5460

taaggattat gctgcactgt actacaaaat tgtagtactt ttttttgttt tcttttttaa   5520

agaaatggaa aatgtttact attacaggga cctcaacact gccctcccat acaggctgga   5580

taaaactgtt tttaagtcag tgattttaga ctgacctcca tttaaattat gtttatatat   5640

gaactttact ctgacctgtg atcatgtttc aggaaggaat gaaagagagt tctttcttaa   5700

taaagaaaaa cactcaagga ctttgttcat ttccaaagct acttgtttac attgtacact   5760

gcgaccacct tgccgctttt catcacaagc ttgaatattt aaattctgta cttatatctg   5820

taaaatagcc aggaatttcc tgtttgtgat ctattatgcc tttttacaaa aaaaatggct   5880

gtaaattatt gtaaatatta aaggaacttt ccttacttcc ttccctttct caggcttttt   5940

ttgactgttc ctttccctac caactcaggc cttcttatta aaaaaaaaaa aatcagtgta   6000

ataacacttt ttaatgattt gtcttgatgg aatcattgtt tagaatgtaa aaatggggaa   6060

aggggccact taattccatt agtcctcttt ttatactgaa tattttatta gatacatgtt   6120

attccctttt ttttcctttt ttagtcaata ttgtgtttgt agttttaaaa aatggcgaga   6180

tatgtaaaat ctaaactgca tgctctggaa acactttttt cagatgcatc tggtttaaaa   6240

gggtaggtgt ataaacactt ttcagaatcc aaaacggcca aaagttattg taaatccgtt   6300

tgttttcccg ttttatgtgg gcaataatgt caaatgtgct atgcagccag gttaacattt   6360

tagataaact tgattgactt ttaatataaa ctgttacaat gcacactgat tgtatataaa   6420

aacgttatat atgacaaatt aaatttaaga aaaagga                            6457


<210>  281
<211>  1710
<212>  PRT
<213>  Homo sapiens

<400>  281

Met Asn Gly His Ser Asp Glu Glu Ser Val Arg Asn Ser Ser Gly Glu 
1               5                   10                  15


Ser Ser Gln Ser Asp Asp Asp Ser Gly Ser Ala Ser Gly Ser Gly Ser 
            20                  25                  30


Gly Ser Ser Ser Gly Ser Ser Ser Asp Gly Ser Ser Ser Gln Ser Gly 
        35                  40                  45


Ser Ser Asp Ser Asp Ser Gly Ser Glu Ser Gly Ser Gln Ser Glu Ser 
    50                  55                  60


Glu Ser Asp Thr Ser Arg Glu Asn Lys Val Gln Ala Lys Pro Pro Lys 
65                  70                  75                  80


Val Asp Gly Ala Glu Phe Trp Lys Ser Ser Pro Ser Ile Leu Ala Val 
                85                  90                  95


Gln Arg Ser Ala Ile Leu Lys Lys Gln Gln Gln Gln Gln Gln Gln Gln 
            100                 105                 110


Gln His Gln Ala Ser Ser Asn Ser Gly Ser Glu Glu Asp Ser Ser Ser 
        115                 120                 125


Ser Glu Asp Ser Asp Asp Ser Ser Ser Glu Val Lys Arg Lys Lys His 
    130                 135                 140


Lys Asp Glu Asp Trp Gln Met Ser Gly Ser Gly Ser Pro Ser Gln Ser 
145                 150                 155                 160


Gly Ser Asp Ser Glu Ser Glu Glu Glu Arg Glu Lys Ser Ser Cys Asp 
                165                 170                 175


Glu Thr Glu Ser Asp Tyr Glu Pro Lys Asn Lys Val Lys Ser Arg Lys 
            180                 185                 190


Pro Gln Asn Arg Ser Lys Ser Lys Asn Gly Lys Lys Ile Leu Gly Gln 
        195                 200                 205


Lys Lys Arg Gln Ile Asp Ser Ser Glu Glu Asp Asp Asp Glu Glu Asp 
    210                 215                 220


Tyr Asp Asn Asp Lys Arg Ser Ser Arg Arg Gln Ala Thr Val Asn Val 
225                 230                 235                 240


Ser Tyr Lys Glu Asp Glu Glu Met Lys Thr Asp Ser Asp Asp Leu Leu 
                245                 250                 255


Glu Val Cys Gly Glu Asp Val Pro Gln Pro Glu Glu Glu Glu Phe Glu 
            260                 265                 270


Thr Ile Glu Arg Phe Met Asp Cys Arg Ile Gly Arg Lys Gly Ala Thr 
        275                 280                 285


Gly Ala Thr Thr Thr Ile Tyr Ala Val Glu Ala Asp Gly Asp Pro Asn 
    290                 295                 300


Ala Gly Phe Glu Lys Asn Lys Glu Pro Gly Glu Ile Gln Tyr Leu Ile 
305                 310                 315                 320


Lys Trp Lys Gly Trp Ser His Ile His Asn Thr Trp Glu Thr Glu Glu 
                325                 330                 335


Thr Leu Lys Gln Gln Asn Val Arg Gly Met Lys Lys Leu Asp Asn Tyr 
            340                 345                 350


Lys Lys Lys Asp Gln Glu Thr Lys Arg Trp Leu Lys Asn Ala Ser Pro 
        355                 360                 365


Glu Asp Val Glu Tyr Tyr Asn Cys Gln Gln Glu Leu Thr Asp Asp Leu 
    370                 375                 380


His Lys Gln Tyr Gln Ile Val Glu Arg Ile Ile Ala His Ser Asn Gln 
385                 390                 395                 400


Lys Ser Ala Ala Gly Tyr Pro Asp Tyr Tyr Cys Lys Trp Gln Gly Leu 
                405                 410                 415


Pro Tyr Ser Glu Cys Ser Trp Glu Asp Gly Ala Leu Ile Ser Lys Lys 
            420                 425                 430


Phe Gln Ala Cys Ile Asp Glu Tyr Phe Ser Arg Asn Gln Ser Lys Thr 
        435                 440                 445


Thr Pro Phe Lys Asp Cys Lys Val Leu Lys Gln Arg Pro Arg Phe Val 
    450                 455                 460


Ala Leu Lys Lys Gln Pro Ser Tyr Ile Gly Gly His Glu Gly Leu Glu 
465                 470                 475                 480


Leu Arg Asp Tyr Gln Leu Asn Gly Leu Asn Trp Leu Ala His Ser Trp 
                485                 490                 495


Cys Lys Gly Asn Ser Cys Ile Leu Ala Asp Glu Met Gly Leu Gly Lys 
            500                 505                 510


Thr Ile Gln Thr Ile Ser Phe Leu Asn Tyr Leu Phe His Glu His Gln 
        515                 520                 525


Leu Tyr Gly Pro Phe Leu Leu Val Val Pro Leu Ser Thr Leu Thr Ser 
    530                 535                 540


Trp Gln Arg Glu Ile Gln Thr Trp Ala Ser Gln Met Asn Ala Val Val 
545                 550                 555                 560


Tyr Leu Gly Asp Ile Asn Ser Arg Asn Met Ile Arg Thr His Glu Trp 
                565                 570                 575


Thr His His Gln Thr Lys Arg Leu Lys Phe Asn Ile Leu Leu Thr Thr 
            580                 585                 590


Tyr Glu Ile Leu Leu Lys Asp Lys Ala Phe Leu Gly Gly Leu Asn Trp 
        595                 600                 605


Ala Phe Ile Gly Val Asp Glu Ala His Arg Leu Lys Asn Asp Asp Ser 
    610                 615                 620


Leu Leu Tyr Lys Thr Leu Ile Asp Phe Lys Ser Asn His Arg Leu Leu 
625                 630                 635                 640


Ile Thr Gly Thr Pro Leu Gln Asn Ser Leu Lys Glu Leu Trp Ser Leu 
                645                 650                 655


Leu His Phe Ile Met Pro Glu Lys Phe Ser Ser Trp Glu Asp Phe Glu 
            660                 665                 670


Glu Glu His Gly Lys Gly Arg Glu Tyr Gly Tyr Ala Ser Leu His Lys 
        675                 680                 685


Glu Leu Glu Pro Phe Leu Leu Arg Arg Val Lys Lys Asp Val Glu Lys 
    690                 695                 700


Ser Leu Pro Ala Lys Val Glu Gln Ile Leu Arg Met Glu Met Ser Ala 
705                 710                 715                 720


Leu Gln Lys Gln Tyr Tyr Lys Trp Ile Leu Thr Arg Asn Tyr Lys Ala 
                725                 730                 735


Leu Ser Lys Gly Ser Lys Gly Ser Thr Ser Gly Phe Leu Asn Ile Met 
            740                 745                 750


Met Glu Leu Lys Lys Cys Cys Asn His Cys Tyr Leu Ile Lys Pro Pro 
        755                 760                 765


Asp Asn Asn Glu Phe Tyr Asn Lys Gln Glu Ala Leu Gln His Leu Ile 
    770                 775                 780


Arg Ser Ser Gly Lys Leu Ile Leu Leu Asp Lys Leu Leu Ile Arg Leu 
785                 790                 795                 800


Arg Glu Arg Gly Asn Arg Val Leu Ile Phe Ser Gln Met Val Arg Met 
                805                 810                 815


Leu Asp Ile Leu Ala Glu Tyr Leu Lys Tyr Arg Gln Phe Pro Phe Gln 
            820                 825                 830


Arg Leu Asp Gly Ser Ile Lys Gly Glu Leu Arg Lys Gln Ala Leu Asp 
        835                 840                 845


His Phe Asn Ala Glu Gly Ser Glu Asp Phe Cys Phe Leu Leu Ser Thr 
    850                 855                 860


Arg Ala Gly Gly Leu Gly Ile Asn Leu Ala Ser Ala Asp Thr Val Val 
865                 870                 875                 880


Ile Phe Asp Ser Asp Trp Asn Pro Gln Asn Asp Leu Gln Ala Gln Ala 
                885                 890                 895


Arg Ala His Arg Ile Gly Gln Lys Lys Gln Val Asn Ile Tyr Arg Leu 
            900                 905                 910


Val Thr Lys Gly Ser Val Glu Glu Asp Ile Leu Glu Arg Ala Lys Lys 
        915                 920                 925


Lys Met Val Leu Asp His Leu Val Ile Gln Arg Met Asp Thr Thr Gly 
    930                 935                 940


Lys Thr Val Leu His Thr Gly Ser Ala Pro Ser Ser Ser Thr Pro Phe 
945                 950                 955                 960


Asn Lys Glu Glu Leu Ser Ala Ile Leu Lys Phe Gly Ala Glu Glu Leu 
                965                 970                 975


Phe Lys Glu Pro Glu Gly Glu Glu Gln Glu Pro Gln Glu Met Asp Ile 
            980                 985                 990


Asp Glu Ile Leu Lys Arg Ala Glu Thr His Glu Asn Glu Pro Gly Pro 
        995                 1000                1005


Leu Thr Val Gly Asp Glu Leu Leu Ser Gln Phe Lys Val Ala Asn Phe 
    1010                1015                1020


Ser Asn Met Asp Glu Asp Asp Ile Glu Leu Glu Pro Glu Arg Asn Ser 
1025                1030                1035                1040


Lys Asn Trp Glu Glu Ile Ile Pro Glu Asp Gln Arg Arg Arg Leu Glu 
                1045                1050                1055


Glu Glu Glu Arg Gln Lys Glu Leu Glu Glu Ile Tyr Met Leu Pro Arg 
            1060                1065                1070


Met Arg Asn Cys Ala Lys Gln Ile Ser Phe Asn Gly Ser Glu Gly Arg 
        1075                1080                1085


Arg Ser Arg Ser Arg Arg Tyr Ser Gly Ser Asp Ser Asp Ser Ile Ser 
    1090                1095                1100


Glu Gly Lys Arg Pro Lys Lys Arg Gly Arg Pro Arg Thr Ile Pro Arg 
1105                1110                1115                1120


Glu Asn Ile Lys Gly Phe Ser Asp Ala Glu Ile Arg Arg Phe Ile Lys 
                1125                1130                1135


Ser Tyr Lys Lys Phe Gly Gly Pro Leu Glu Arg Leu Asp Ala Ile Ala 
            1140                1145                1150


Arg Asp Ala Glu Leu Val Asp Lys Ser Glu Thr Asp Leu Arg Arg Leu 
        1155                1160                1165


Gly Glu Leu Val His Asn Gly Cys Ile Lys Ala Leu Lys Asp Ser Ser 
    1170                1175                1180


Ser Gly Thr Glu Arg Thr Gly Gly Arg Leu Gly Lys Val Lys Gly Pro 
1185                1190                1195                1200


Thr Phe Arg Ile Ser Gly Val Gln Val Asn Ala Lys Leu Val Ile Ser 
                1205                1210                1215


His Glu Glu Glu Leu Ile Pro Leu His Lys Ser Ile Pro Ser Asp Pro 
            1220                1225                1230


Glu Glu Arg Lys Gln Tyr Thr Ile Pro Cys His Thr Lys Ala Ala His 
        1235                1240                1245


Phe Asp Ile Asp Trp Gly Lys Glu Asp Asp Ser Asn Leu Leu Ile Gly 
    1250                1255                1260


Ile Tyr Glu Tyr Gly Tyr Gly Ser Trp Glu Met Ile Lys Met Asp Pro 
1265                1270                1275                1280


Asp Leu Ser Leu Thr His Lys Ile Leu Pro Asp Asp Pro Asp Lys Lys 
                1285                1290                1295


Pro Gln Ala Lys Gln Leu Gln Thr Arg Ala Asp Tyr Leu Ile Lys Leu 
            1300                1305                1310


Leu Ser Arg Asp Leu Ala Lys Lys Glu Ala Leu Ser Gly Ala Gly Ser 
        1315                1320                1325


Ser Lys Arg Arg Lys Ala Arg Ala Lys Lys Asn Lys Ala Met Lys Ser 
    1330                1335                1340


Ile Lys Val Lys Glu Glu Ile Lys Ser Asp Ser Ser Pro Leu Pro Ser 
1345                1350                1355                1360


Glu Lys Ser Asp Glu Asp Asp Asp Lys Leu Ser Glu Ser Lys Ser Asp 
                1365                1370                1375


Gly Arg Glu Arg Ser Lys Lys Ser Ser Val Ser Asp Ala Pro Val His 
            1380                1385                1390


Ile Thr Ala Ser Gly Glu Pro Val Pro Ile Ser Glu Glu Ser Glu Glu 
        1395                1400                1405


Leu Asp Gln Lys Thr Phe Ser Ile Cys Lys Glu Arg Met Arg Pro Val 
    1410                1415                1420


Lys Ala Ala Leu Lys Gln Leu Asp Arg Pro Glu Lys Gly Leu Ser Glu 
1425                1430                1435                1440


Arg Glu Gln Leu Glu His Thr Arg Gln Cys Leu Ile Lys Ile Gly Asp 
                1445                1450                1455


His Ile Thr Glu Cys Leu Lys Glu Tyr Thr Asn Pro Glu Gln Ile Lys 
            1460                1465                1470


Gln Trp Arg Lys Asn Leu Trp Ile Phe Val Ser Lys Phe Thr Glu Phe 
        1475                1480                1485


Asp Ala Arg Lys Leu His Lys Leu Tyr Lys His Ala Ile Lys Lys Arg 
    1490                1495                1500


Gln Glu Ser Gln Gln Asn Ser Asp Gln Asn Ser Asn Leu Asn Pro His 
1505                1510                1515                1520


Val Ile Arg Asn Pro Asp Val Glu Arg Leu Lys Glu Asn Thr Asn His 
                1525                1530                1535


Asp Asp Ser Ser Arg Asp Ser Tyr Ser Ser Asp Arg His Leu Thr Gln 
            1540                1545                1550


Tyr His Asp His His Lys Asp Arg His Gln Gly Asp Ser Tyr Lys Lys 
        1555                1560                1565


Ser Asp Ser Arg Lys Arg Pro Tyr Ser Ser Phe Ser Asn Gly Lys Asp 
    1570                1575                1580


His Arg Asp Trp Asp His Tyr Lys Gln Asp Ser Arg Tyr Tyr Ser Asp 
1585                1590                1595                1600


Arg Glu Lys His Arg Lys Leu Asp Asp His Arg Ser Arg Asp His Arg 
                1605                1610                1615


Ser Asn Leu Glu Gly Ser Leu Lys Asp Arg Ser His Ser Asp His Arg 
            1620                1625                1630


Ser His Ser Asp His Arg Leu His Ser Asp His Arg Ser Ser Ser Glu 
        1635                1640                1645


Tyr Thr His His Lys Ser Ser Arg Asp Tyr Arg Tyr His Ser Asp Trp 
    1650                1655                1660


Gln Met Asp His Arg Ala Ser Ser Ser Gly Pro Arg Ser Pro Leu Asp 
1665                1670                1675                1680


Gln Arg Ser Pro Tyr Gly Ser Arg Ser Pro Phe Glu His Ser Val Glu 
                1685                1690                1695


His Lys Ser Thr Pro Glu His Thr Trp Ser Ser Arg Lys Thr 
            1700                1705                1710


<210>  282
<211>  2168
<212>  DNA
<213>  Homo sapiens

<400>  282
ctctctcgct cctgcgttcg caggcggcgg ctggcggccg gcttctcgct cgggcagcgg     60

cggcggcggc ggcggcggct tccggagtcc cgctgcgaag atgctcaaag tcacggtgcc    120

ctcctgctcc gcctcgtcct gctcttcggt caccgccagt gcggccccgg ggaccgcgag    180

cctcgtcccg gattactgga tcgacggctc caacagggat gcgctgagcg atttcttcga    240

ggtggagtcg gagctgggac ggggtgctac atccattgtg tacagatgca aacagaaggg    300

gacccagaag ccttatgctc tcaaagtgtt aaagaaaaca gtggacaaaa aaatcgtaag    360

aactgagata ggagttcttc ttcgcctctc acatccaaac attataaaac ttaaagagat    420

atttgaaacc cctacagaaa tcagtctggt cctagaactc gtcacaggag gagaactgtt    480

tgataggatt gtggaaaagg gatattacag tgagcgagat gctgcagatg ccgttaaaca    540

aatcctggag gcagttgctt atctacatga aaatgggatt gtccatcgtg atctcaaacc    600

agagaatctt ctttatgcaa ctccagcccc agatgcacca ctcaaaatcg ctgattttgg    660

actctctaaa attgtggaac atcaagtgct catgaagaca gtatgtggaa ccccagggta    720

ctgcgcacct gaaattctta gaggttgtgc ctatggacct gaggtggaca tgtggtctgt    780

aggaataatc acctacatct tactttgtgg atttgaacca ttctatgatg aaagaggcga    840

tcagttcatg ttcaggagaa ttctgaattg tgaatattac tttatctccc cctggtggga    900

tgaagtatct ctaaatgcca aggacttggt cagaaaatta attgttttgg atccaaagaa    960

acggctgact acatttcaag ctctccagca tccgtgggtc acaggtaaag cagccaattt   1020

tgtacacatg gataccgctc aaaagaagct ccaagaattc aatgcccggc gtaagcttaa   1080

ggcagcggtg aaggctgtgg tggcctcttc gcgcctggga agtgccagca gcagccatgg   1140

cagcatccag gagagccaca aggctagccg agacccttct ccaatccaag atggcaacga   1200

ggacatgaaa gctattccag aaggagagaa aattcaaggc gatggggccc aagccgcagt   1260

taagggggca caggctgagc tgatgaaggt gcaagcctta gagaaagtta aaggtgcaga   1320

tataaatgct gaagaggccc ccaaaatggt gcccaaggca gtggaggatg ggataaaggt   1380

ggctgacctg gaactagagg agggcctagc agaggagaag ctgaagactg tggaggaggc   1440

agcagctccc agagaagggc aaggaagctc tgctgtgggt tttgaagttc cacagcaaga   1500

tgtgatcctg ccagagtact aaacagcttc cttcagatct ggaagccaaa caccggcatt   1560

ttatgtactt tgtccttcag caagaaaggt gtggaagcat gatatgtact atagtgattc   1620

tgtttttgag gtgcaaaaaa catacatata taccagttgg taattctaac ttcaatgcat   1680

gtgactgctt tatgaaaata atagtgtctt ctatggcatg taatggatac ctaataccga   1740

tgagttaaat cttgcaagtt aacacaacgt aacacttaaa agcatacatt ttcagcaacc   1800

agtggcacat atttgaagtg aatagtagca aattgttttt gctttgaaaa tctagccatc   1860

ctacatcctt tggatttctt cacaaggcag taattccttt gaactactgc ttagctaata   1920

ctaggtagtg ctaaaagaca tgttcccata acttttacaa cattttactt tttatcattg   1980

atgtgttcaa actgtttaca aggagatgct tatagatgat agttgtacat atgtgcaaaa   2040

aaaaatccac ttgcaatggt aagaaattga agtatcctta aaggccatga agccatatgt   2100

ccctaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2160

aaaaaaaa                                                            2168


<210>  283
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  283

Met Leu Lys Val Thr Val Pro Ser Cys Ser Ala Ser Ser Cys Ser Ser 
1               5                   10                  15


Val Thr Ala Ser Ala Ala Pro Gly Thr Ala Ser Leu Val Pro Asp Tyr 
            20                  25                  30


Trp Ile Asp Gly Ser Asn Arg Asp Ala Leu Ser Asp Phe Phe Glu Val 
        35                  40                  45


Glu Ser Glu Leu Gly Arg Gly Ala Thr Ser Ile Val Tyr Arg Cys Lys 
    50                  55                  60


Gln Lys Gly Thr Gln Lys Pro Tyr Ala Leu Lys Val Leu Lys Lys Thr 
65                  70                  75                  80


Val Asp Lys Lys Ile Val Arg Thr Glu Ile Gly Val Leu Leu Arg Leu 
                85                  90                  95


Ser His Pro Asn Ile Ile Lys Leu Lys Glu Ile Phe Glu Thr Pro Thr 
            100                 105                 110


Glu Ile Ser Leu Val Leu Glu Leu Val Thr Gly Gly Glu Leu Phe Asp 
        115                 120                 125


Arg Ile Val Glu Lys Gly Tyr Tyr Ser Glu Arg Asp Ala Ala Asp Ala 
    130                 135                 140


Val Lys Gln Ile Leu Glu Ala Val Ala Tyr Leu His Glu Asn Gly Ile 
145                 150                 155                 160


Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Tyr Ala Thr Pro Ala 
                165                 170                 175


Pro Asp Ala Pro Leu Lys Ile Ala Asp Phe Gly Leu Ser Lys Ile Val 
            180                 185                 190


Glu His Gln Val Leu Met Lys Thr Val Cys Gly Thr Pro Gly Tyr Cys 
        195                 200                 205


Ala Pro Glu Ile Leu Arg Gly Cys Ala Tyr Gly Pro Glu Val Asp Met 
    210                 215                 220


Trp Ser Val Gly Ile Ile Thr Tyr Ile Leu Leu Cys Gly Phe Glu Pro 
225                 230                 235                 240


Phe Tyr Asp Glu Arg Gly Asp Gln Phe Met Phe Arg Arg Ile Leu Asn 
                245                 250                 255


Cys Glu Tyr Tyr Phe Ile Ser Pro Trp Trp Asp Glu Val Ser Leu Asn 
            260                 265                 270


Ala Lys Asp Leu Val Arg Lys Leu Ile Val Leu Asp Pro Lys Lys Arg 
        275                 280                 285


Leu Thr Thr Phe Gln Ala Leu Gln His Pro Trp Val Thr Gly Lys Ala 
    290                 295                 300


Ala Asn Phe Val His Met Asp Thr Ala Gln Lys Lys Leu Gln Glu Phe 
305                 310                 315                 320


Asn Ala Arg Arg Lys Leu Lys Ala Ala Val Lys Ala Val Val Ala Ser 
                325                 330                 335


Ser Arg Leu Gly Ser Ala Ser Ser Ser His Gly Ser Ile Gln Glu Ser 
            340                 345                 350


His Lys Ala Ser Arg Asp Pro Ser Pro Ile Gln Asp Gly Asn Glu Asp 
        355                 360                 365


Met Lys Ala Ile Pro Glu Gly Glu Lys Ile Gln Gly Asp Gly Ala Gln 
    370                 375                 380


Ala Ala Val Lys Gly Ala Gln Ala Glu Leu Met Lys Val Gln Ala Leu 
385                 390                 395                 400


Glu Lys Val Lys Gly Ala Asp Ile Asn Ala Glu Glu Ala Pro Lys Met 
                405                 410                 415


Val Pro Lys Ala Val Glu Asp Gly Ile Lys Val Ala Asp Leu Glu Leu 
            420                 425                 430


Glu Glu Gly Leu Ala Glu Glu Lys Leu Lys Thr Val Glu Glu Ala Ala 
        435                 440                 445


Ala Pro Arg Glu Gly Gln Gly Ser Ser Ala Val Gly Phe Glu Val Pro 
    450                 455                 460


Gln Gln Asp Val Ile Leu Pro Glu Tyr 
465                 470


<210>  284
<211>  2264
<212>  DNA
<213>  Homo sapiens

<400>  284
actgttgaga gcggtgtgag gtgcttggta gcgcgccgta gctgcttcca cgtccttgct     60

tcacctcagg taaagagaga agtaatggaa ggcctgtctg atgttgcttc ttttgcaact    120

aaacttaaaa acactctcat ccagtaccat agcattgaag aagataagtg gcgagttgct    180

aagaaaacga aagatgtaac tgtttggaga aaaccctcag aagaatttaa tggatatctc    240

tacaaagccc aaggtgttat agatgacctt gtctatagta taatagacca tatacgccca    300

gggccttgtc gtttggattg ggacagcttg atgacttctt tggatattct ggagaacttt    360

gaagagaatt gctgtgtgat gcgttacact actgctggtc agctttggaa tataatttcc    420

ccaagagaat ttgttgattt ctcctatact gtgggctata aagaagggct tttatcttgt    480

ggaataagtc ttgactggga tgaaaagaga ccagaatttg ttcgaggata taaccatccc    540

tgtggttggt tttgtgttcc acttaaagac aacccaaacc agagtctttt gacaggatat    600

attcagacag atctgcgtgg gatgattcct cagtctgcgg tagatacagc catggcaagc    660

actttaacca acttctatgg tgatttacga aaagctttat gagaggcaaa atacattcaa    720

acttgtagta ctacagatca actctctcag ctacatggcc tgtaaaaatc attgattcca    780

cttttctgca tagccggtag aaaaatttga aatgtttttg gttcactagt acaatgtttg    840

gttttattcc taaagtaaat agctatctaa gagagggcat tttcactttt ttttttttaa    900

attttgagac aggctctcac tctgttgccc atgctggagg gcagtggtat gatcacagct    960

cactgcagct ttgatctgac cgctcaaggg gttattctac ctcagcctcc tgaatagctg   1020

ggaatacagg tgcacgccac tatgcatggc taatttttgt ttaatttttt gtagagatgt   1080

ggtcacactg tgttgcccag gctggtcttg aactcctggc ctcaagtcat tccccacctt   1140

agcctcccaa agtgttggga ttataagcgt gagccaccat gcctggcccc aatttaaaat   1200

gtggaattca gttggtgtcc aagacttatc ttgagactct taaaagcatc agtctgtaac   1260

tagaacaaat acagtcttag atttacccaa gtgcctagat atcattttat aatgattaga   1320

attgagtatt gtgggtcccc taattctgtg ggtgccttaa gtgagaattt ctaaatgatt   1380

ttcacattct aaatgacttt gggttttgaa ctctccatct agtttacttc taaaatggga   1440

acttgaggca attcaggtat ccaggcaaat ctttgtatat atttttttgt gtacatgcac   1500

acatctcgaa atccatttcc gtgtttaatg ttagttgttt atgtgttagt attcctgtgt   1560

ctactgtttt gttgttgtta atatgggtaa agtgagccct gaaatacatg ctaaacaaga   1620

catgaaattc agaaaggtac atagtgtttc aagtgcatgg tagtttgatc tgtgttttac   1680

tttattgtgt tttcttgagt gtaaagaaag aataaatcaa agttcttcat acccattttg   1740

acaaagtgga acagtggagc tgttttttgc ttttgttttt atttattttt tgccactggt   1800

gatgatagat ttcaaaaaac aaaaggtggc agcagcacaa tgttcatggt gaattatctc   1860

atagtatcta gattgatcaa gatctgacag aaggaatgca caaaggattc tatattctta   1920

atgatttatt aattaccagg atccttttct aaattgaatg tacttttgaa ttactaggtt   1980

tcttcttttt ttttgttctg caatagtgaa agaaaactca gtagtttagt ttcagtttct   2040

catggaaatt ggtaaatgtt agttttgact tcatctattt tttatttgtt tttattagcg   2100

tagagtagga agtctcatat tctactgttc tatctaggat ggtgaaattc caaaggtgcc   2160

taacttgagt aagggatttg tgacaagata gtacacatta ctataagggc tattatttcc   2220

tgaactggat gtccctaaaa gcaaataaac tgcccactat ctct                    2264


<210>  285
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  285

Met Glu Gly Leu Ser Asp Val Ala Ser Phe Ala Thr Lys Leu Lys Asn 
1               5                   10                  15


Thr Leu Ile Gln Tyr His Ser Ile Glu Glu Asp Lys Trp Arg Val Ala 
            20                  25                  30


Lys Lys Thr Lys Asp Val Thr Val Trp Arg Lys Pro Ser Glu Glu Phe 
        35                  40                  45


Asn Gly Tyr Leu Tyr Lys Ala Gln Gly Val Ile Asp Asp Leu Val Tyr 
    50                  55                  60


Ser Ile Ile Asp His Ile Arg Pro Gly Pro Cys Arg Leu Asp Trp Asp 
65                  70                  75                  80


Ser Leu Met Thr Ser Leu Asp Ile Leu Glu Asn Phe Glu Glu Asn Cys 
                85                  90                  95


Cys Val Met Arg Tyr Thr Thr Ala Gly Gln Leu Trp Asn Ile Ile Ser 
            100                 105                 110


Pro Arg Glu Phe Val Asp Phe Ser Tyr Thr Val Gly Tyr Lys Glu Gly 
        115                 120                 125


Leu Leu Ser Cys Gly Ile Ser Leu Asp Trp Asp Glu Lys Arg Pro Glu 
    130                 135                 140


Phe Val Arg Gly Tyr Asn His Pro Cys Gly Trp Phe Cys Val Pro Leu 
145                 150                 155                 160


Lys Asp Asn Pro Asn Gln Ser Leu Leu Thr Gly Tyr Ile Gln Thr Asp 
                165                 170                 175


Leu Arg Gly Met Ile Pro Gln Ser Ala Val Asp Thr Ala Met Ala Ser 
            180                 185                 190


Thr Leu Thr Asn Phe Tyr Gly Asp Leu Arg Lys Ala Leu 
        195                 200                 205


<210>  286
<211>  3283
<212>  DNA
<213>  Homo sapiens

<400>  286
cccgccagct cgcggagccg ctctgccccg cgccctagcc cgcgcctgca gcccgcccag     60

gcggagtcag cccgcgctcc gcccgccgcg atccgagctc ggaggttcgg actccgggct    120

cgccgccccc cgggccggct ccgcgccccg cactcccggc gcccagcgcc ccgcgccccg    180

gcgggcggag cgcaccatgc cgcagctgga ctccggcggg ggcggcgcgg gcggcggcga    240

cgacctcggc gcgccggacg agctgctggc cttccaggat gaaggcgagg agcaggacga    300

caagagccgc gacagcgccg ccggtcccga gcgcgacctg gccgagctca agtcgtcgct    360

cgtgaacgag tccgagggcg cggccggcgg cgcagggatc ccgggggtcc cgggggccgg    420

cgccggggcc cgcggcgagg ccgaggctct cgggcgggaa cacgctgcgc agagactctt    480

cccggacaaa cttccagagc ccctggagga cggcctgaag gccccggagt gcaccagcgg    540

catgtacaaa gagaccgtct actccgcctt caatctgctc atgcattacc cacccccctc    600

gggagcaggg cagcaccccc agccgcagcc cccgctgcac aaggccaatc agccccccca    660

cggtgtcccc caactctctc tctacgaaca tttcaacagc ccacatccca cccctgcacc    720

tgcggacatc agccagaagc aagttcacag gcctctgcag acccctgacc tctctggctt    780

ctactccctg acctcaggca gcatggggca gctcccccac actgtgagct ggttcaccca    840

cccatccttg atgctaggtt ctggtgtacc tggtcaccca gcagccatcc cccacccggc    900

cattgtgccc ccctcaggga agcaggagct gcagcccttc gaccgcaacc tgaagacaca    960

agcagagtcc aaggcagaga aggaggccaa gaagccaacc atcaagaagc ccctcaatgc   1020

cttcatgctg tacatgaagg agatgagagc caaggtcatt gcagagtgca cacttaagga   1080

gagcgctgcc atcaaccaga tcctgggccg caggtggcac gcgctgtcgc gagaagagca   1140

ggccaagtac tatgagctgg cccgcaagga gaggcagctg cacatgcagc tatacccagg   1200

ctggtcagcg cgggacaact acgggaagaa gaagaggcgg tcgagggaaa agcaccaaga   1260

atccaccaca ggaggaaaaa gaaatgcatt cggtacttac ccggagaagg ccgctgcccc   1320

agccccgttc cttccgatga cagtgctcta ggctgccccg ggtccccagc tccccaggac   1380

tcaccctcat accatctgct gccccgcttc cccacagaac tgcttactag ccctgcggag   1440

ccggcaccta catccccagg tctctccact gctctcagcc tcccaacccc agggccccca   1500

caggcccccc gcagcaccct gcagagcaca caggtacagc aacaggaatc tcagagacag   1560

gtggcctagc aggcacagga cacctggccg cctccaggag cctaccccct gaaagtgaca   1620

gagacccaga tctcatggaa actggccagg ggtcctgtta acgtcatctc agggtccaga   1680

ccctgaagat ttcagaggct gcaggacttc tgcctgaacc tggggtcatc gattcaaact   1740

gctccaagtg gtgggaatca gatctgtctt gatgtgtcat ctaattaagg gaatcccttg   1800

tacctatggc tgcctgcatc tattctttgt accatctgtc ttgccagcca gaagcctctg   1860

cctccctagc ttttctgcta taggtcagag atgggctgaa ctgagcctag ctaccttctc   1920

tacccatctc ccccatcccc cactgccaca ccctccccat tcagacactt catggaccaa   1980

gaatgagctg gtttgtcaaa caacatgtga gcatggtcac aagcacaaag ctcaagatga   2040

cagctcttct aaggaaatgg agaagctctg tttataaaaa caaaaacaaa accagctgct   2100

actcataagt tggaccagag gaagcccctt actatgatct caggagcttg caagaagcag   2160

gaaggggaat ggaataggtt aagtttaggc ctatcaacct aagcaacaga aataatctga   2220

cactacctta tcaggcaaat tggggagggg agggtgtatc tagctctagt tcaaattatt   2280

tggaagtgtt ccctgagaaa cccaccagcc taagaagctc tggccccagg cttgtcacta   2340

gcagctgcag tcaacagttc aaagaagtca tggcccaaat ccagtgtgca cccctcccca   2400

ttcacagagc ctttttcaca attccatttc cagttcatct atggcagtcc agccagctcc   2460

tgggcagctt gagagggcaa acccaaaacc tcatgacagc cagagcctgt ctttcagcat   2520

tcagtccgcc tggccggctc cagtttcccc atggggctgc gggacagagg accattacaa   2580

ctagatcaag gagcccagaa aacctccagt agtggacaac aggttttcac catagcctac   2640

gttaacccat ttttgagcca agcttcaacc ctcagccttg aaaaacaagt ctttaattta   2700

atttttgttt tttgcctaaa tccaaagaaa aagggctgcc gggccaggcg cggtggctca   2760

cgcctgtaat cccagcactt tggcaggccg aggcaggtgg atcacctgac gtcagtagtt   2820

tgagaccagc ctggccaaca tggtgaaacc ctgtatctac taaaaataca aaaattagcc   2880

ggacgtggtg gtgcgcgcat gtaatcccag ctactcggga ggctgaggcg gaagaatcac   2940

ttgaacccgg gaggcggagg ttccagtgag ccgagatggc gctattgcac tccagtctgg   3000

gtaacaggga gactgcatct caaaaaaaaa aaaaaaaaaa aaaaagggct gtccatgtat   3060

tcacacaccc ctcaaaaaaa gcctttagtt cctactttag ccactggttt ctcagaatcc   3120

aaagatcaca tattctagtg taacactgca agaagtcttg agaaaaagat tattgtagtg   3180

ttcaaaatat ttttgtattg ttaatgcatc atcatagaaa aacttttaaa catgagaata   3240

aagatacttt ttactgggtt tgtttttcaa agcctgaaaa aaa                     3283


<210>  287
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  287

Met Pro Gln Leu Asp Ser Gly Gly Gly Gly Ala Gly Gly Gly Asp Asp 
1               5                   10                  15


Leu Gly Ala Pro Asp Glu Leu Leu Ala Phe Gln Asp Glu Gly Glu Glu 
            20                  25                  30


Gln Asp Asp Lys Ser Arg Asp Ser Ala Ala Gly Pro Glu Arg Asp Leu 
        35                  40                  45


Ala Glu Leu Lys Ser Ser Leu Val Asn Glu Ser Glu Gly Ala Ala Gly 
    50                  55                  60


Gly Ala Gly Ile Pro Gly Val Pro Gly Ala Gly Ala Gly Ala Arg Gly 
65                  70                  75                  80


Glu Ala Glu Ala Leu Gly Arg Glu His Ala Ala Gln Arg Leu Phe Pro 
                85                  90                  95


Asp Lys Leu Pro Glu Pro Leu Glu Asp Gly Leu Lys Ala Pro Glu Cys 
            100                 105                 110


Thr Ser Gly Met Tyr Lys Glu Thr Val Tyr Ser Ala Phe Asn Leu Leu 
        115                 120                 125


Met His Tyr Pro Pro Pro Ser Gly Ala Gly Gln His Pro Gln Pro Gln 
    130                 135                 140


Pro Pro Leu His Lys Ala Asn Gln Pro Pro His Gly Val Pro Gln Leu 
145                 150                 155                 160


Ser Leu Tyr Glu His Phe Asn Ser Pro His Pro Thr Pro Ala Pro Ala 
                165                 170                 175


Asp Ile Ser Gln Lys Gln Val His Arg Pro Leu Gln Thr Pro Asp Leu 
            180                 185                 190


Ser Gly Phe Tyr Ser Leu Thr Ser Gly Ser Met Gly Gln Leu Pro His 
        195                 200                 205


Thr Val Ser Trp Phe Thr His Pro Ser Leu Met Leu Gly Ser Gly Val 
    210                 215                 220


Pro Gly His Pro Ala Ala Ile Pro His Pro Ala Ile Val Pro Pro Ser 
225                 230                 235                 240


Gly Lys Gln Glu Leu Gln Pro Phe Asp Arg Asn Leu Lys Thr Gln Ala 
                245                 250                 255


Glu Ser Lys Ala Glu Lys Glu Ala Lys Lys Pro Thr Ile Lys Lys Pro 
            260                 265                 270


Leu Asn Ala Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val Ile 
        275                 280                 285


Ala Glu Cys Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly 
    290                 295                 300


Arg Arg Trp His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu 
305                 310                 315                 320


Leu Ala Arg Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly Trp 
                325                 330                 335


Ser Ala Arg Asp Asn Tyr Gly Lys Lys Lys Arg Arg Ser Arg Glu Lys 
            340                 345                 350


His Gln Glu Ser Thr Thr Gly Gly Lys Arg Asn Ala Phe Gly Thr Tyr 
        355                 360                 365


Pro Glu Lys Ala Ala Ala Pro Ala Pro Phe Leu Pro Met Thr Val Leu 
    370                 375                 380


<210>  288
<211>  2821
<212>  DNA
<213>  Homo sapiens

<400>  288
gcccaggtga ctgactaatc cgccgccttc aggagacaga attggccaag gcctgaaggc     60

cccggagtgc accagcggca tgtacaaaga gaccgtctac tccgccttca atctgctcat    120

gcattaccca cccccctcgg gagcagggca gcacccccag ccgcagcccc cgctgcacaa    180

ggccaatcag cccccccacg gtgtccccca actctctctc tacgaacatt tcaacagccc    240

acatcccacc cctgcacctg cggacatcag ccagaagcaa gttcacaggc ctctgcagac    300

ccctgacctc tctggcttct actccctgac ctcaggcagc atggggcagc tcccccacac    360

tgtgagctgg ttcacccacc catccttgat gctaggttct ggtgtacctg gtcacccagc    420

agccatcccc cacccggcca ttgtgccccc ctcagggaag caggagctgc agcccttcga    480

ccgcaacctg aagacacaag cagagtccaa ggcagagaag gaggccaaga agccaaccat    540

caagaagccc ctcaatgcct tcatgctgta catgaaggag atgagagcca aggtcattgc    600

agagtgcaca cttaaggaga gcgctgccat caaccagatc ctgggccgca ggtggcacgc    660

gctgtcgcga gaagagcagg ccaagtacta tgagctggcc cgcaaggaga ggcagctgca    720

catgcagcta tacccaggct ggtcagcgcg ggacaactac gggaagaaga agaggcggtc    780

gagggaaaag caccaagaat ccaccacagg aggaaaaaga aatgcattcg gtacttaccc    840

ggagaaggcc gctgccccag ccccgttcct tccgatgaca gtgctctagg ctgccccggg    900

tccccagctc cccaggactc accctcatac catctgctgc cccgcttccc cacagaactg    960

cttactagcc ctgcggagcc ggcacctaca tccccaggtc tctccactgc tctcagcctc   1020

ccaaccccag ggcccccaca ggccccccgc agcaccctgc agagcacaca ggtacagcaa   1080

caggaatctc agagacaggt ggcctagcag gcacaggaca cctggccgcc tccaggagcc   1140

taccccctga aagtgacaga gacccagatc tcatggaaac tggccagggg tcctgttaac   1200

gtcatctcag ggtccagacc ctgaagattt cagaggctgc aggacttctg cctgaacctg   1260

gggtcatcga ttcaaactgc tccaagtggt gggaatcaga tctgtcttga tgtgtcatct   1320

aattaaggga atcccttgta cctatggctg cctgcatcta ttctttgtac catctgtctt   1380

gccagccaga agcctctgcc tccctagctt ttctgctata ggtcagagat gggctgaact   1440

gagcctagct accttctcta cccatctccc ccatccccca ctgccacacc ctccccattc   1500

agacacttca tggaccaaga atgagctggt ttgtcaaaca acatgtgagc atggtcacaa   1560

gcacaaagct caagatgaca gctcttctaa ggaaatggag aagctctgtt tataaaaaca   1620

aaaacaaaac cagctgctac tcataagttg gaccagagga agccccttac tatgatctca   1680

ggagcttgca agaagcagga aggggaatgg aataggttaa gtttaggcct atcaacctaa   1740

gcaacagaaa taatctgaca ctaccttatc aggcaaattg gggaggggag ggtgtatcta   1800

gctctagttc aaattatttg gaagtgttcc ctgagaaacc caccagccta agaagctctg   1860

gccccaggct tgtcactagc agctgcagtc aacagttcaa agaagtcatg gcccaaatcc   1920

agtgtgcacc cctccccatt cacagagcct ttttcacaat tccatttcca gttcatctat   1980

ggcagtccag ccagctcctg ggcagcttga gagggcaaac ccaaaacctc atgacagcca   2040

gagcctgtct ttcagcattc agtccgcctg gccggctcca gtttccccat ggggctgcgg   2100

gacagaggac cattacaact agatcaagga gcccagaaaa cctccagtag tggacaacag   2160

gttttcacca tagcctacgt taacccattt ttgagccaag cttcaaccct cagccttgaa   2220

aaacaagtct ttaatttaat ttttgttttt tgcctaaatc caaagaaaaa gggctgccgg   2280

gccaggcgcg gtggctcacg cctgtaatcc cagcactttg gcaggccgag gcaggtggat   2340

cacctgacgt cagtagtttg agaccagcct ggccaacatg gtgaaaccct gtatctacta   2400

aaaatacaaa aattagccgg acgtggtggt gcgcgcatgt aatcccagct actcgggagg   2460

ctgaggcgga agaatcactt gaacccggga ggcggaggtt ccagtgagcc gagatggcgc   2520

tattgcactc cagtctgggt aacagggaga ctgcatctca aaaaaaaaaa aaaaaaaaaa   2580

aaagggctgt ccatgtattc acacacccct caaaaaaagc ctttagttcc tactttagcc   2640

actggtttct cagaatccaa agatcacata ttctagtgta acactgcaag aagtcttgag   2700

aaaaagatta ttgtagtgtt caaaatattt ttgtattgtt aatgcatcat catagaaaaa   2760

cttttaaaca tgagaataaa gatacttttt actgggtttg tttttcaaag cctgaaaaaa   2820

a                                                                   2821


<210>  289
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  289

Met Tyr Lys Glu Thr Val Tyr Ser Ala Phe Asn Leu Leu Met His Tyr 
1               5                   10                  15


Pro Pro Pro Ser Gly Ala Gly Gln His Pro Gln Pro Gln Pro Pro Leu 
            20                  25                  30


His Lys Ala Asn Gln Pro Pro His Gly Val Pro Gln Leu Ser Leu Tyr 
        35                  40                  45


Glu His Phe Asn Ser Pro His Pro Thr Pro Ala Pro Ala Asp Ile Ser 
    50                  55                  60


Gln Lys Gln Val His Arg Pro Leu Gln Thr Pro Asp Leu Ser Gly Phe 
65                  70                  75                  80


Tyr Ser Leu Thr Ser Gly Ser Met Gly Gln Leu Pro His Thr Val Ser 
                85                  90                  95


Trp Phe Thr His Pro Ser Leu Met Leu Gly Ser Gly Val Pro Gly His 
            100                 105                 110


Pro Ala Ala Ile Pro His Pro Ala Ile Val Pro Pro Ser Gly Lys Gln 
        115                 120                 125


Glu Leu Gln Pro Phe Asp Arg Asn Leu Lys Thr Gln Ala Glu Ser Lys 
    130                 135                 140


Ala Glu Lys Glu Ala Lys Lys Pro Thr Ile Lys Lys Pro Leu Asn Ala 
145                 150                 155                 160


Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val Ile Ala Glu Cys 
                165                 170                 175


Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly Arg Arg Trp 
            180                 185                 190


His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu Leu Ala Arg 
        195                 200                 205


Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly Trp Ser Ala Arg 
    210                 215                 220


Asp Asn Tyr Gly Lys Lys Lys Arg Arg Ser Arg Glu Lys His Gln Glu 
225                 230                 235                 240


Ser Thr Thr Gly Gly Lys Arg Asn Ala Phe Gly Thr Tyr Pro Glu Lys 
                245                 250                 255


Ala Ala Ala Pro Ala Pro Phe Leu Pro Met Thr Val Leu 
            260                 265


<210>  290
<211>  1254
<212>  DNA
<213>  Homo sapiens

<400>  290
gcccaggtga ctgactaatc cgccgccttc aggagacaga attggccaag gcctgaaggc     60

cccggagtgc accagcggca tgtacaaaga gaccgtctac tccgccttca atctgctcat    120

gcattaccca cccccctcgg gagcagggca gcacccccag ccgcagcccc cgctgcacaa    180

ggccaatcag cccccccacg gtgtccccca actctctctc tacgaacatt tcaacagccc    240

acatcccacc cctgcacctg cggacatcag ccagaagcaa gttcacaggc ctctgcagac    300

ccctgacctc tctggcttct actccctgac ctcaggcagc atggggcagc tcccccacac    360

tgtgagctgg ttcacccacc catccttgat gctaggttct ggtgtacctg gtcacccagc    420

agccatcccc cacccggcca ttgtgccccc ctcagggaag caggagctgc agcccttcga    480

ccgcaacctg aagacacaag cagagtccaa ggcagagaag gaggccaaga agccaaccat    540

caagaagccc ctcaatgcct tcatgctgta catgaaggag atgagagcca aggtcattgc    600

agagtgcaca cttaaggaga gcgctgccat caaccagatc ctgggccgca ggtggcacgc    660

gctgtcgcga gaagagcagg ccaagtacta tgagctggcc cgcaaggaga ggcagctgca    720

catgcagcta tacccaggct ggtcagcgcg ggacaactac gggaagaaga agaggcggtc    780

gagggaaaag caccaagaat ccaccacaga gacaaactgg cccagagaac tcaaggatgg    840

taatggacaa gagtcactgt ccatgtcttc ttcctctagc ccagcttgag gactgggatg    900

gctgggcaag gaagccatag gcattgcggc cccttgcctt ggtgcagatg tgagtcccac    960

aaacacatct ggagaagctc aaaggccggg actgggagat gactcccttg gaagacagga   1020

gagatgactc ccttggaaga cagatgacag cccataggcc tagtgacaaa aggccccttt   1080

ccgaccttgt ggctgttctg ggaactgcac ctgtcctagg tctgggccag accaagcaga   1140

atggcagtct gaggacactg acttaccacc caagtcccag gaagagagga caaggaatca   1200

gccaggcctg tgcaaaggca gcattttttg gttgtggagt atgactatga attc         1254


<210>  291
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  291

Met Tyr Lys Glu Thr Val Tyr Ser Ala Phe Asn Leu Leu Met His Tyr 
1               5                   10                  15


Pro Pro Pro Ser Gly Ala Gly Gln His Pro Gln Pro Gln Pro Pro Leu 
            20                  25                  30


His Lys Ala Asn Gln Pro Pro His Gly Val Pro Gln Leu Ser Leu Tyr 
        35                  40                  45


Glu His Phe Asn Ser Pro His Pro Thr Pro Ala Pro Ala Asp Ile Ser 
    50                  55                  60


Gln Lys Gln Val His Arg Pro Leu Gln Thr Pro Asp Leu Ser Gly Phe 
65                  70                  75                  80


Tyr Ser Leu Thr Ser Gly Ser Met Gly Gln Leu Pro His Thr Val Ser 
                85                  90                  95


Trp Phe Thr His Pro Ser Leu Met Leu Gly Ser Gly Val Pro Gly His 
            100                 105                 110


Pro Ala Ala Ile Pro His Pro Ala Ile Val Pro Pro Ser Gly Lys Gln 
        115                 120                 125


Glu Leu Gln Pro Phe Asp Arg Asn Leu Lys Thr Gln Ala Glu Ser Lys 
    130                 135                 140


Ala Glu Lys Glu Ala Lys Lys Pro Thr Ile Lys Lys Pro Leu Asn Ala 
145                 150                 155                 160


Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val Ile Ala Glu Cys 
                165                 170                 175


Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly Arg Arg Trp 
            180                 185                 190


His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu Leu Ala Arg 
        195                 200                 205


Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly Trp Ser Ala Arg 
    210                 215                 220


Asp Asn Tyr Gly Lys Lys Lys Arg Arg Ser Arg Glu Lys His Gln Glu 
225                 230                 235                 240


Ser Thr Thr Glu Thr Asn Trp Pro Arg Glu Leu Lys Asp Gly Asn Gly 
                245                 250                 255


Gln Glu Ser Leu Ser Met Ser Ser Ser Ser Ser Pro Ala 
            260                 265


<210>  292
<211>  2917
<212>  DNA
<213>  Homo sapiens

<400>  292
gcccaggtga ctgactaatc cgccgccttc aggagacaga attggccaag gcctgaaggc     60

cccggagtgc accagcggca tgtacaaaga gaccgtctac tccgccttca atctgctcat    120

gcattaccca cccccctcgg gagcagggca gcacccccag ccgcagcccc cgctgcacaa    180

ggccaatcag cccccccacg gtgtccccca actctctctc tacgaacatt tcaacagccc    240

acatcccacc cctgcacctg cggacatcag ccagaagcaa gttcacaggc ctctgcagac    300

ccctgacctc tctggcttct actccctgac ctcaggcagc atggggcagc tcccccacac    360

tgtgagctgg ttcacccacc catccttgat gctaggttct ggtgtacctg gtcacccagc    420

agccatcccc cacccggcca ttgtgccccc ctcagggaag caggagctgc agcccttcga    480

ccgcaacctg aagacacaag cagagtccaa ggcagagaag gaggccaaga agccaaccat    540

caagaagccc ctcaatgcct tcatgctgta catgaaggag atgagagcca aggtcattgc    600

agagtgcaca cttaaggaga gcgctgccat caaccagatc ctgggccgca ggtggcacgc    660

gctgtcgcga gaagagcagg ccaagtacta tgagctggcc cgcaaggaga ggcagctgca    720

catgcagcta tacccaggct ggtcagcgcg ggacaactac gggaagaaga agaggcggtc    780

gagggaaaag caccaagaat ccaccacaga ccctggctcg cctaagaaat gccgtgctcg    840

ctttggcctc aaccagcaga cggattggtg tggtccgtgc agataactct cttcactatt    900

cctaggagga aaaagaaatg cattcggtac ttacccggag aaggccgctg ccccagcccc    960

gttccttccg atgacagtgc tctaggctgc cccgggtccc cagctcccca ggactcaccc   1020

tcataccatc tgctgccccg cttccccaca gaactgctta ctagccctgc ggagccggca   1080

cctacatccc caggtctctc cactgctctc agcctcccaa ccccagggcc cccacaggcc   1140

ccccgcagca ccctgcagag cacacaggta cagcaacagg aatctcagag acaggtggcc   1200

tagcaggcac aggacacctg gccgcctcca ggagcctacc ccctgaaagt gacagagacc   1260

cagatctcat ggaaactggc caggggtcct gttaacgtca tctcagggtc cagaccctga   1320

agatttcaga ggctgcagga cttctgcctg aacctggggt catcgattca aactgctcca   1380

agtggtggga atcagatctg tcttgatgtg tcatctaatt aagggaatcc cttgtaccta   1440

tggctgcctg catctattct ttgtaccatc tgtcttgcca gccagaagcc tctgcctccc   1500

tagcttttct gctataggtc agagatgggc tgaactgagc ctagctacct tctctaccca   1560

tctcccccat cccccactgc cacaccctcc ccattcagac acttcatgga ccaagaatga   1620

gctggtttgt caaacaacat gtgagcatgg tcacaagcac aaagctcaag atgacagctc   1680

ttctaaggaa atggagaagc tctgtttata aaaacaaaaa caaaaccagc tgctactcat   1740

aagttggacc agaggaagcc ccttactatg atctcaggag cttgcaagaa gcaggaaggg   1800

gaatggaata ggttaagttt aggcctatca acctaagcaa cagaaataat ctgacactac   1860

cttatcaggc aaattgggga ggggagggtg tatctagctc tagttcaaat tatttggaag   1920

tgttccctga gaaacccacc agcctaagaa gctctggccc caggcttgtc actagcagct   1980

gcagtcaaca gttcaaagaa gtcatggccc aaatccagtg tgcacccctc cccattcaca   2040

gagccttttt cacaattcca tttccagttc atctatggca gtccagccag ctcctgggca   2100

gcttgagagg gcaaacccaa aacctcatga cagccagagc ctgtctttca gcattcagtc   2160

cgcctggccg gctccagttt ccccatgggg ctgcgggaca gaggaccatt acaactagat   2220

caaggagccc agaaaacctc cagtagtgga caacaggttt tcaccatagc ctacgttaac   2280

ccatttttga gccaagcttc aaccctcagc cttgaaaaac aagtctttaa tttaattttt   2340

gttttttgcc taaatccaaa gaaaaagggc tgccgggcca ggcgcggtgg ctcacgcctg   2400

taatcccagc actttggcag gccgaggcag gtggatcacc tgacgtcagt agtttgagac   2460

cagcctggcc aacatggtga aaccctgtat ctactaaaaa tacaaaaatt agccggacgt   2520

ggtggtgcgc gcatgtaatc ccagctactc gggaggctga ggcggaagaa tcacttgaac   2580

ccgggaggcg gaggttccag tgagccgaga tggcgctatt gcactccagt ctgggtaaca   2640

gggagactgc atctcaaaaa aaaaaaaaaa aaaaaaaaag ggctgtccat gtattcacac   2700

acccctcaaa aaaagccttt agttcctact ttagccactg gtttctcaga atccaaagat   2760

cacatattct agtgtaacac tgcaagaagt cttgagaaaa agattattgt agtgttcaaa   2820

atatttttgt attgttaatg catcatcata gaaaaacttt taaacatgag aataaagata   2880

ctttttactg ggtttgtttt tcaaagcctg aaaaaaa                            2917


<210>  293
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  293

Met Tyr Lys Glu Thr Val Tyr Ser Ala Phe Asn Leu Leu Met His Tyr 
1               5                   10                  15


Pro Pro Pro Ser Gly Ala Gly Gln His Pro Gln Pro Gln Pro Pro Leu 
            20                  25                  30


His Lys Ala Asn Gln Pro Pro His Gly Val Pro Gln Leu Ser Leu Tyr 
        35                  40                  45


Glu His Phe Asn Ser Pro His Pro Thr Pro Ala Pro Ala Asp Ile Ser 
    50                  55                  60


Gln Lys Gln Val His Arg Pro Leu Gln Thr Pro Asp Leu Ser Gly Phe 
65                  70                  75                  80


Tyr Ser Leu Thr Ser Gly Ser Met Gly Gln Leu Pro His Thr Val Ser 
                85                  90                  95


Trp Phe Thr His Pro Ser Leu Met Leu Gly Ser Gly Val Pro Gly His 
            100                 105                 110


Pro Ala Ala Ile Pro His Pro Ala Ile Val Pro Pro Ser Gly Lys Gln 
        115                 120                 125


Glu Leu Gln Pro Phe Asp Arg Asn Leu Lys Thr Gln Ala Glu Ser Lys 
    130                 135                 140


Ala Glu Lys Glu Ala Lys Lys Pro Thr Ile Lys Lys Pro Leu Asn Ala 
145                 150                 155                 160


Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val Ile Ala Glu Cys 
                165                 170                 175


Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly Arg Arg Trp 
            180                 185                 190


His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu Leu Ala Arg 
        195                 200                 205


Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly Trp Ser Ala Arg 
    210                 215                 220


Asp Asn Tyr Gly Lys Lys Lys Arg Arg Ser Arg Glu Lys His Gln Glu 
225                 230                 235                 240


Ser Thr Thr Asp Pro Gly Ser Pro Lys Lys Cys Arg Ala Arg Phe Gly 
                245                 250                 255


Leu Asn Gln Gln Thr Asp Trp Cys Gly Pro Cys Arg 
            260                 265


<210>  294
<211>  2944
<212>  DNA
<213>  Homo sapiens

<400>  294
cctccaggtc cttcccctaa aacttggcac tgccgatact cccagcccgt tccttcccaa     60

gtcaggaact tgcaggggac cccttggcaa ttctttttct ctcaagagca gacagccttc    120

agtcccagcc gctgccaggg ctggtgtgtc tgacccagct gtggtttttc caggcctgaa    180

ggccccggag tgcaccagcg gcatgtacaa agagaccgtc tactccgcct tcaatctgct    240

catgcattac ccacccccct cgggagcagg gcagcacccc cagccgcagc ccccgctgca    300

caaggccaat cagccccccc acggtgtccc ccaactctct ctctacgaac atttcaacag    360

cccacatccc acccctgcac ctgcggacat cagccagaag caagttcaca ggcctctgca    420

gacccctgac ctctctggct tctactccct gacctcaggc agcatggggc agctccccca    480

cactgtgagc tggttcaccc acccatcctt gatgctaggt tctggtgtac ctggtcaccc    540

agcagccatc ccccacccgg ccattgtgcc cccctcaggg aagcaggagc tgcagccctt    600

cgaccgcaac ctgaagacac aagcagagtc caaggcagag aaggaggcca agaagccaac    660

catcaagaag cccctcaatg ccttcatgct gtacatgaag gagatgagag ccaaggtcat    720

tgcagagtgc acacttaagg agagcgctgc catcaaccag atcctgggcc gcaggtggca    780

cgcgctgtcg cgagaagagc aggccaagta ctatgagctg gcccgcaagg agaggcagct    840

gcacatgcag ctatacccag gctggtcagc gcgggacaac tacgggaaga agaagaggcg    900

gtcgagggaa aagcaccaag aatccaccac aggaggaaaa agaaatgcat tcggtactta    960

cccggagaag gccgctgccc cagccccgtt ccttccgatg acagtgctct aggctgcccc   1020

gggtccccag ctccccagga ctcaccctca taccatctgc tgccccgctt ccccacagaa   1080

ctgcttacta gccctgcgga gccggcacct acatccccag gtctctccac tgctctcagc   1140

ctcccaaccc cagggccccc acaggccccc cgcagcaccc tgcagagcac acaggtacag   1200

caacaggaat ctcagagaca ggtggcctag caggcacagg acacctggcc gcctccagga   1260

gcctaccccc tgaaagtgac agagacccag atctcatgga aactggccag gggtcctgtt   1320

aacgtcatct cagggtccag accctgaaga tttcagaggc tgcaggactt ctgcctgaac   1380

ctggggtcat cgattcaaac tgctccaagt ggtgggaatc agatctgtct tgatgtgtca   1440

tctaattaag ggaatccctt gtacctatgg ctgcctgcat ctattctttg taccatctgt   1500

cttgccagcc agaagcctct gcctccctag cttttctgct ataggtcaga gatgggctga   1560

actgagccta gctaccttct ctacccatct cccccatccc ccactgccac accctcccca   1620

ttcagacact tcatggacca agaatgagct ggtttgtcaa acaacatgtg agcatggtca   1680

caagcacaaa gctcaagatg acagctcttc taaggaaatg gagaagctct gtttataaaa   1740

acaaaaacaa aaccagctgc tactcataag ttggaccaga ggaagcccct tactatgatc   1800

tcaggagctt gcaagaagca ggaaggggaa tggaataggt taagtttagg cctatcaacc   1860

taagcaacag aaataatctg acactacctt atcaggcaaa ttggggaggg gagggtgtat   1920

ctagctctag ttcaaattat ttggaagtgt tccctgagaa acccaccagc ctaagaagct   1980

ctggccccag gcttgtcact agcagctgca gtcaacagtt caaagaagtc atggcccaaa   2040

tccagtgtgc acccctcccc attcacagag cctttttcac aattccattt ccagttcatc   2100

tatggcagtc cagccagctc ctgggcagct tgagagggca aacccaaaac ctcatgacag   2160

ccagagcctg tctttcagca ttcagtccgc ctggccggct ccagtttccc catggggctg   2220

cgggacagag gaccattaca actagatcaa ggagcccaga aaacctccag tagtggacaa   2280

caggttttca ccatagccta cgttaaccca tttttgagcc aagcttcaac cctcagcctt   2340

gaaaaacaag tctttaattt aatttttgtt ttttgcctaa atccaaagaa aaagggctgc   2400

cgggccaggc gcggtggctc acgcctgtaa tcccagcact ttggcaggcc gaggcaggtg   2460

gatcacctga cgtcagtagt ttgagaccag cctggccaac atggtgaaac cctgtatcta   2520

ctaaaaatac aaaaattagc cggacgtggt ggtgcgcgca tgtaatccca gctactcggg   2580

aggctgaggc ggaagaatca cttgaacccg ggaggcggag gttccagtga gccgagatgg   2640

cgctattgca ctccagtctg ggtaacaggg agactgcatc tcaaaaaaaa aaaaaaaaaa   2700

aaaaaagggc tgtccatgta ttcacacacc cctcaaaaaa agcctttagt tcctacttta   2760

gccactggtt tctcagaatc caaagatcac atattctagt gtaacactgc aagaagtctt   2820

gagaaaaaga ttattgtagt gttcaaaata tttttgtatt gttaatgcat catcatagaa   2880

aaacttttaa acatgagaat aaagatactt tttactgggt ttgtttttca aagcctgaaa   2940

aaaa                                                                2944


<210>  295
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  295

Met Tyr Lys Glu Thr Val Tyr Ser Ala Phe Asn Leu Leu Met His Tyr 
1               5                   10                  15


Pro Pro Pro Ser Gly Ala Gly Gln His Pro Gln Pro Gln Pro Pro Leu 
            20                  25                  30


His Lys Ala Asn Gln Pro Pro His Gly Val Pro Gln Leu Ser Leu Tyr 
        35                  40                  45


Glu His Phe Asn Ser Pro His Pro Thr Pro Ala Pro Ala Asp Ile Ser 
    50                  55                  60


Gln Lys Gln Val His Arg Pro Leu Gln Thr Pro Asp Leu Ser Gly Phe 
65                  70                  75                  80


Tyr Ser Leu Thr Ser Gly Ser Met Gly Gln Leu Pro His Thr Val Ser 
                85                  90                  95


Trp Phe Thr His Pro Ser Leu Met Leu Gly Ser Gly Val Pro Gly His 
            100                 105                 110


Pro Ala Ala Ile Pro His Pro Ala Ile Val Pro Pro Ser Gly Lys Gln 
        115                 120                 125


Glu Leu Gln Pro Phe Asp Arg Asn Leu Lys Thr Gln Ala Glu Ser Lys 
    130                 135                 140


Ala Glu Lys Glu Ala Lys Lys Pro Thr Ile Lys Lys Pro Leu Asn Ala 
145                 150                 155                 160


Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val Ile Ala Glu Cys 
                165                 170                 175


Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly Arg Arg Trp 
            180                 185                 190


His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu Leu Ala Arg 
        195                 200                 205


Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly Trp Ser Ala Arg 
    210                 215                 220


Asp Asn Tyr Gly Lys Lys Lys Arg Arg Ser Arg Glu Lys His Gln Glu 
225                 230                 235                 240


Ser Thr Thr Gly Gly Lys Arg Asn Ala Phe Gly Thr Tyr Pro Glu Lys 
                245                 250                 255


Ala Ala Ala Pro Ala Pro Phe Leu Pro Met Thr Val Leu 
            260                 265


<210>  296
<211>  2172
<212>  DNA
<213>  Homo sapiens

<400>  296
ctgcgccctc tcctataaag cagacgccgc gccgcgctgc gacgctgtag tggcttcgtc     60

ttcggttttt ctcttccttc gctaacgcct cccggctctc gtcagcctcc cgccggccgt    120

ctccttaaca ccgaacacca tgccttcaat taagttgcag agttctgatg gagagatatt    180

tgaagttgat gtggaaattg ccaaacaatc tgtgactatt aagaccatgt tggaagattt    240

gggaatggat gatgaaggag atgatgaccc agttcctcta ccaaatgtga atgcagcaat    300

attaaaaaag gtcattcagt ggtgcaccca ccacaaggat gaccctcctc ctcctgaaga    360

tgatgagaac aaagaaaagc gaacagatga tatccctgtt tgggaccaag aattcctgaa    420

agttgaccaa ggaacacttt ttgaactcat tctggctgca aactacttag acatcaaagg    480

tttgcttgat gttacatgca agactgttgc caatatgatc aaggggaaaa ctcctgagga    540

gattcgcaag accttcaata tcaaaaatga ctttactgaa gaggaggaag cccaggtagg    600

tagcacacag ttttgtcttt gatcacatgc tcttaaaaag ggagtaacac ctataacatg    660

ccagcaaaag aggtgactgt atcaagtagt cttgatactt tagggataat atgtacttaa    720

tgtgtcttaa acatactctt actgttctgt ctttatgaat ctgaacactt agatgatact    780

gcattttaag cataagaaca attagttttc aatgagaaga gctcttgtta atgtattaac    840

agttactagt tttggcacct gcaactttct gtatagacca tacatatctg acatcagaaa    900

agcaggccct agagagaagt atatactagg gtactttaga gcaacttaat gaggggagga    960

aatgaaagaa tagatcagaa tgattttgtt gacatgacta cagactgaaa taatgtgaat   1020

gaattaactg aatttgctct gtcaacttta gtaaattgcc cattgccttt gctttgttca   1080

taatttcagc agggcagaat aaaaaccatg ggaggcaaag aaaggaaatc cggaaatata   1140

gtcttaacct ggtgttgttc taattttcca tctgttcttc tgactcaact cactggctat   1200

cgatgaatca gtaggtagta tttataagtc ttaggaaaga ctactcaagt taaggtactt   1260

ccctatatcc atctctttta ggtacgcaaa gagaaccagt ggtgtgaaga gaagtgaaat   1320

gttgtgcctg acactgtaac actgtaagga ttgttccaaa tactagttgc actgctctgt   1380

ttataattgt taatattaga caaacagtag acaaatgcag cagcaagtca attgtattag   1440

cagaatattg tcctcattgc atgtgtagtt tgagcacaga tcccaaacct tacggccaag   1500

tttcttctag tatgatggaa agtttctttt ttctttgctc tgaataaaac tgaactgtgg   1560

gttctctata agtggcattt tgggctttcc ctcttttttg taaagcaatg tctgcctagt   1620

ttattgtcca gttaacttta gtgacctttt aaaagttggc attgtaaata aaacaacttg   1680

caaaaaagtt ttctggaata gaattaacaa aatattatct ttattcatga gttggaaact   1740

ggaaaaaggc ttcttgaagt aaatgttctg agtggagcta ctaggatgtc ttccagcctc   1800

ctgcagtcaa ggagtaccac tgtattgatt agcctgtatg tagcagggct cccttcattg   1860

catctgagga cttgttttct ttttctttat ttttaatcct cttagtttta aatatattgc   1920

ctagagactc agttactacc cagtttgtgg ttttttggga gaaatgtaac tggacagtta   1980

gcttttcaat taaaaagaca cttaacccat gtgggatgtc atctttttat aattagtgtt   2040

cccatgtgga gaaaattatt cacactactt gcatgtaaag aataatttaa cttttaacat   2100

taaaatatgt ggtaaaaccc agaaagcatc catcatgaat gcaagatact ttcaataaaa   2160

agtaagttat at                                                       2172


<210>  297
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  297

Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95


Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp 
    130                 135                 140


Phe Thr Glu Glu Glu Glu Ala Gln Val Gly Ser Thr Gln Phe Cys Leu 
145                 150                 155                 160


<210>  298
<211>  1486
<212>  DNA
<213>  Homo sapiens

<400>  298
ctgcgccctc tcctataaag cagacgccgc gccgcgctgc gacgctgtag tggcttcgtc     60

ttcggttttt ctcttccttc gctaacgcct cccggctctc gtcagcctcc cgccggccgt    120

ctccttaaca ccgaacacca tgccttcaat taagttgcag agttctgatg gagagatatt    180

tgaagttgat gtggaaattg ccaaacaatc tgtgactatt aagaccatgt tggaagattt    240

gggaatggat gatgaaggag atgatgaccc agttcctcta ccaaatgtga atgcagcaat    300

attaaaaaag gtcattcagt ggtgcaccca ccacaaggat gaccctcctc ctcctgaaga    360

tgatgagaac aaagaaaagc gaacagatga tatccctgtt tgggaccaag aattcctgaa    420

agttgaccaa ggaacacttt ttgaactcat tctggctgca aactacttag acatcaaagg    480

tttgcttgat gttacatgca agactgttgc caatatgatc aaggggaaaa ctcctgagga    540

gattcgcaag accttcaata tcaaaaatga ctttactgaa gaggaggaag cccaggtacg    600

caaagagaac cagtggtgtg aagagaagtg aaatgttgtg cctgacactg taacactgta    660

aggattgttc caaatactag ttgcactgct ctgtttataa ttgttaatat tagacaaaca    720

gtagacaaat gcagcagcaa gtcaattgta ttagcagaat attgtcctca ttgcatgtgt    780

agtttgagca cagatcccaa accttacggc caagtttctt ctagtatgat ggaaagtttc    840

ttttttcttt gctctgaata aaactgaact gtgggttctc tataagtggc attttgggct    900

ttccctcttt tttgtaaagc aatgtctgcc tagtttattg tccagttaac tttagtgacc    960

ttttaaaagt tggcattgta aataaaacaa cttgcaaaaa agttttctgg aatagaatta   1020

acaaaatatt atctttattc atgagttgga aactggaaaa aggcttcttg aagtaaatgt   1080

tctgagtgga gctactagga tgtcttccag cctcctgcag tcaaggagta ccactgtatt   1140

gattagcctg tatgtagcag ggctcccttc attgcatctg aggacttgtt ttctttttct   1200

ttatttttaa tcctcttagt tttaaatata ttgcctagag actcagttac tacccagttt   1260

gtggtttttt gggagaaatg taactggaca gttagctttt caattaaaaa gacacttaac   1320

ccatgtggga tgtcatcttt ttataattag tgttcccatg tggagaaaat tattcacact   1380

acttgcatgt aaagaataat ttaactttta acattaaaat atgtggtaaa acccagaaag   1440

catccatcat gaatgcaaga tactttcaat aaaaagtaag ttatat                  1486


<210>  299
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  299

Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95


Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp 
    130                 135                 140


Phe Thr Glu Glu Glu Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys 
145                 150                 155                 160


Glu Glu Lys 



<210>  300
<211>  2643
<212>  DNA
<213>  Homo sapiens

<400>  300
gcttcagtta ccagccggct acgtcgcgcc tgcgctttga cccccagttt gcgccccaac     60

tccggtcgtg cggccgcccg gggagggctc tgcagttgcg cagcttgctc cccggccctt    120

ttcccctccg ctccccgccg cctcctgacg ccgggcgtga cgtcaccacg cccggcggcc    180

gccattacag agagccgagc tctggagcct cagcgagcgg aggaggaggc gcagcggccg    240

acggccgagt actgcggtga gagccagcgg gccagcgcca gcctcaacag ccgccagaag    300

tacacgagga accggcggcg gcgtgtgcgt gtaggcccgt gtgcgggcgg cggcgcggga    360

gcagcgcgga gcggcagccg gctggggcgg gtggcatcat ggacgagaag gtgttcacca    420

aggagctgga ccagtggatc gagcagctga acgagtgcaa gcagctgtcc gagtcccagg    480

tcaagagcct ctgcgagaag gctaaagaaa tcctgacaaa agaatccaac gtgcaagagg    540

ttcgatgtcc agttactgtc tgtggagatg tgcatgggca atttcatgat ctcatggaac    600

tgtttagaat tggtggcaaa tcaccagata caaattactt gtttatggga gattatgttg    660

acagaggata ttattcagtt gaaacagtta cactgcttgt agctcttaag gttcgttacc    720

gtgaacgcat caccattctt cgagggaatc atgagagcag acagatcaca caagtttatg    780

gtttctatga tgaatgttta agaaaatatg gaaatgcaaa tgtttggaaa tattttacag    840

atctttttga ctatcttcct ctcactgcct tggtggatgg gcagatcttc tgtctacatg    900

gtggtctctc gccatctata gatacactgg atcatatcag agcacttgat cgcctacaag    960

aagttcccca tgagggtcca atgtgtgact tgctgtggtc agatccagat gaccgtggtg   1020

gttggggtat atctcctcga ggagctggtt acacctttgg gcaagatatt tctgagacat   1080

ttaatcatgc caatggcctc acgttggtgt ctagagctca ccagctagtg atggagggat   1140

ataactggtg ccatgaccgg aatgtagtaa cgattttcag tgctccaaac tattgttatc   1200

gttgtggtaa ccaagctgca atcatggaac ttgacgatac tctaaaatac tctttcttgc   1260

agtttgaccc agcacctcgt agaggcgagc cacatgttac tcgtcgtacc ccagactact   1320

tcctgtaatg aaattttaaa cttgtacagt attgccatga accatatatc gacctaatgg   1380

aaatgggaag agcaacagta actccaaagt gtcagaaaat agttaacatt caaaaaactt   1440

gttttcacat ggaccaaaag atgtgccata taaaaataca aagcctcttg tcatcaacag   1500

ccgtgaccac tttagaatga accagttcat tgcatgctga agcgacattg ttggtcaaga   1560

aaccagtttc tggcatagcg ctatttgtag ttacttttgc tttctctgag agactgcaga   1620

taataagatg taaacattaa cacctcgtga atacaattta acttccattt agctatagct   1680

ttactcagca tgactgtaga taaggatagc agcaaacaat cattggagct taatgaacat   1740

ttttaaaaat aattaccaag gcctcccttc tacttgtgag ttttgaaatt gttcttttta   1800

ttttcaggga taccgtttaa tttaattata tgatttgtct gcactcagtt tattccctac   1860

tcaaatctca gccccatgtt gttctttgtt attgtcagaa cctggtgagt tgttttgaac   1920

agaactgttt tttccccttc ctgtaagacg atgtgactgc acaagagcac tgcagtgttt   1980

ttcataataa acttgtgaac taagaactga gaaggtcaaa ttttaattgt atcaatgggc   2040

aagactggtg ctgtttatta aaaaagttaa atcaattgag taaattttag aatttgtaga   2100

cttgtaggta aaataaaaat caagggcact acataacctc tctggtaact ccttgacatt   2160

cttcagatta acttcaggat ttatttgtat ttcacatatt acaatttgtc acattgttgg   2220

tgtgcacttt gtgggttctt cctgcatatt aacttgtttg taagaaagga aatctgtgct   2280

gcttcagtaa gacttaattg taaaaccata taacttgaga tttaagtctt tgggttttgt   2340

tttaataaaa cagcatgttt tcaggtagag cttaaactaa atgatgtgtt tacttagtgc   2400

agtttctggt tatgaatatt atattgctat gtgtatatta tatggactct ttaaaatgat   2460

tgacagattg gcaaattctt aaatctttgt acattgttga gtcatatgtt cttagagtta   2520

aatttgtctc agataagaaa gtgttaaagc attagcctgt gtcaagttct ttgagtgata   2580

ctagtgaaac caaatagaaa actattgttg gatcatgatt tagtcttatg tacattcacc   2640

cga                                                                 2643


<210>  301
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  301

Met Asp Glu Lys Val Phe Thr Lys Glu Leu Asp Gln Trp Ile Glu Gln 
1               5                   10                  15


Leu Asn Glu Cys Lys Gln Leu Ser Glu Ser Gln Val Lys Ser Leu Cys 
            20                  25                  30


Glu Lys Ala Lys Glu Ile Leu Thr Lys Glu Ser Asn Val Gln Glu Val 
        35                  40                  45


Arg Cys Pro Val Thr Val Cys Gly Asp Val His Gly Gln Phe His Asp 
    50                  55                  60


Leu Met Glu Leu Phe Arg Ile Gly Gly Lys Ser Pro Asp Thr Asn Tyr 
65                  70                  75                  80


Leu Phe Met Gly Asp Tyr Val Asp Arg Gly Tyr Tyr Ser Val Glu Thr 
                85                  90                  95


Val Thr Leu Leu Val Ala Leu Lys Val Arg Tyr Arg Glu Arg Ile Thr 
            100                 105                 110


Ile Leu Arg Gly Asn His Glu Ser Arg Gln Ile Thr Gln Val Tyr Gly 
        115                 120                 125


Phe Tyr Asp Glu Cys Leu Arg Lys Tyr Gly Asn Ala Asn Val Trp Lys 
    130                 135                 140


Tyr Phe Thr Asp Leu Phe Asp Tyr Leu Pro Leu Thr Ala Leu Val Asp 
145                 150                 155                 160


Gly Gln Ile Phe Cys Leu His Gly Gly Leu Ser Pro Ser Ile Asp Thr 
                165                 170                 175


Leu Asp His Ile Arg Ala Leu Asp Arg Leu Gln Glu Val Pro His Glu 
            180                 185                 190


Gly Pro Met Cys Asp Leu Leu Trp Ser Asp Pro Asp Asp Arg Gly Gly 
        195                 200                 205


Trp Gly Ile Ser Pro Arg Gly Ala Gly Tyr Thr Phe Gly Gln Asp Ile 
    210                 215                 220


Ser Glu Thr Phe Asn His Ala Asn Gly Leu Thr Leu Val Ser Arg Ala 
225                 230                 235                 240


His Gln Leu Val Met Glu Gly Tyr Asn Trp Cys His Asp Arg Asn Val 
                245                 250                 255


Val Thr Ile Phe Ser Ala Pro Asn Tyr Cys Tyr Arg Cys Gly Asn Gln 
            260                 265                 270


Ala Ala Ile Met Glu Leu Asp Asp Thr Leu Lys Tyr Ser Phe Leu Gln 
        275                 280                 285


Phe Asp Pro Ala Pro Arg Arg Gly Glu Pro His Val Thr Arg Arg Thr 
    290                 295                 300


Pro Asp Tyr Phe Leu 
305


<210>  302
<211>  1513
<212>  DNA
<213>  Homo sapiens

<400>  302
atggagatgt atgaaaccct tggaaaagtg ggagagggaa gttacggaac agtcatgaaa     60

tgtaaacata agaatactgg gcagatagtg gccattaaga tattttatga gagaccagaa    120

caatctgtca acaaaattgc gatgagagaa ataaagtttc taaagcaatt tcatcacgaa    180

aacctggtca atctgattga agtttttaga cagaaaaaga aaattcattt ggtatttgaa    240

tttattgacc acacagtatt agatgagtta caacattatt gtcatggact agagagtaag    300

cgacttagaa aatacctctt ccagatcctt cgagcaattg actatcttca cagtaataat    360

atcattcatc gagatataaa acctgagaat attttagtat cccagtcagg aattactaag    420

ctctgtgatt ttggttttgc acgaacacta gcagctcctg gggacattta tacggactat    480

gtggccacac gctggtatag agctcccgaa ttagtattaa aagatacttc ttatggaaaa    540

cctgtggata tctgggcttt gggctgtatg atcattgaga tggccactgg aaatccctat    600

cttcctagta gttctgattt ggatttactc cataaaattg ttttgaaagt gggcaatttg    660

tcacctcact tgcagaatat cttttccaag agccccattt ttgctggggt agttcttcct    720

caagttcaac accccaaaaa tgcaagaaaa aaatatccaa agcttaatgg attgttggca    780

gatatagttc atgcttgttt acaaattgat cctgctgaca ggatatcatc tagtgatctt    840

ttgcatcatg agtattttac tagagatgga tttattgaaa aattcatgcc agaactgaaa    900

gctaaattac tgcaggaagc aaaagtcaat tcattaataa agccaaaaga gagttctaaa    960

gaaaatgaac tcaggaaaga tgaaagaaaa acagtttata ccaatacact gctaagtagt   1020

tcagttttgg gagaggaaat agaaaaagag aaaaagccca aggagatcaa agtcagagtt   1080

attaaagtca aaggaggaag aggagatatc tcagaaccaa aaaagaaaga gtatgaaggt   1140

ggacttggtc aacaggatgc aaatgaaaat gttcatccta tgtctccaga tacaaaactt   1200

gtaaccattg aaccaccaaa ccctatcaat cccagcacta actgtaatgg cttgaaagaa   1260

aatccacatt gcggaggttc tgtgacaatg ccacccatca atctaactaa cagtaatttg   1320

atggctgcaa atctcagttc aaatctcttt caccccagtg tgaggtgagc tgtaacagag   1380

aagaaaccta aataatacaa cattcctgta taatggtatt tcaaagaatc gtgttcatag   1440

tgtctgtatg taaactgaac ttgaagaaaa tatattgaaa ttaaagctgt ataatgggcc   1500

aaaaaaaaaa aaa                                                      1513


<210>  303
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  303

Met Glu Met Tyr Glu Thr Leu Gly Lys Val Gly Glu Gly Ser Tyr Gly 
1               5                   10                  15


Thr Val Met Lys Cys Lys His Lys Asn Thr Gly Gln Ile Val Ala Ile 
            20                  25                  30


Lys Ile Phe Tyr Glu Arg Pro Glu Gln Ser Val Asn Lys Ile Ala Met 
        35                  40                  45


Arg Glu Ile Lys Phe Leu Lys Gln Phe His His Glu Asn Leu Val Asn 
    50                  55                  60


Leu Ile Glu Val Phe Arg Gln Lys Lys Lys Ile His Leu Val Phe Glu 
65                  70                  75                  80


Phe Ile Asp His Thr Val Leu Asp Glu Leu Gln His Tyr Cys His Gly 
                85                  90                  95


Leu Glu Ser Lys Arg Leu Arg Lys Tyr Leu Phe Gln Ile Leu Arg Ala 
            100                 105                 110


Ile Asp Tyr Leu His Ser Asn Asn Ile Ile His Arg Asp Ile Lys Pro 
        115                 120                 125


Glu Asn Ile Leu Val Ser Gln Ser Gly Ile Thr Lys Leu Cys Asp Phe 
    130                 135                 140


Gly Phe Ala Arg Thr Leu Ala Ala Pro Gly Asp Ile Tyr Thr Asp Tyr 
145                 150                 155                 160


Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu Leu Val Leu Lys Asp Thr 
                165                 170                 175


Ser Tyr Gly Lys Pro Val Asp Ile Trp Ala Leu Gly Cys Met Ile Ile 
            180                 185                 190


Glu Met Ala Thr Gly Asn Pro Tyr Leu Pro Ser Ser Ser Asp Leu Asp 
        195                 200                 205


Leu Leu His Lys Ile Val Leu Lys Val Gly Asn Leu Ser Pro His Leu 
    210                 215                 220


Gln Asn Ile Phe Ser Lys Ser Pro Ile Phe Ala Gly Val Val Leu Pro 
225                 230                 235                 240


Gln Val Gln His Pro Lys Asn Ala Arg Lys Lys Tyr Pro Lys Leu Asn 
                245                 250                 255


Gly Leu Leu Ala Asp Ile Val His Ala Cys Leu Gln Ile Asp Pro Ala 
            260                 265                 270


Asp Arg Ile Ser Ser Ser Asp Leu Leu His His Glu Tyr Phe Thr Arg 
        275                 280                 285


Asp Gly Phe Ile Glu Lys Phe Met Pro Glu Leu Lys Ala Lys Leu Leu 
    290                 295                 300


Gln Glu Ala Lys Val Asn Ser Leu Ile Lys Pro Lys Glu Ser Ser Lys 
305                 310                 315                 320


Glu Asn Glu Leu Arg Lys Asp Glu Arg Lys Thr Val Tyr Thr Asn Thr 
                325                 330                 335


Leu Leu Ser Ser Ser Val Leu Gly Glu Glu Ile Glu Lys Glu Lys Lys 
            340                 345                 350


Pro Lys Glu Ile Lys Val Arg Val Ile Lys Val Lys Gly Gly Arg Gly 
        355                 360                 365


Asp Ile Ser Glu Pro Lys Lys Lys Glu Tyr Glu Gly Gly Leu Gly Gln 
    370                 375                 380


Gln Asp Ala Asn Glu Asn Val His Pro Met Ser Pro Asp Thr Lys Leu 
385                 390                 395                 400


Val Thr Ile Glu Pro Pro Asn Pro Ile Asn Pro Ser Thr Asn Cys Asn 
                405                 410                 415


Gly Leu Lys Glu Asn Pro His Cys Gly Gly Ser Val Thr Met Pro Pro 
            420                 425                 430


Ile Asn Leu Thr Asn Ser Asn Leu Met Ala Ala Asn Leu Ser Ser Asn 
        435                 440                 445


Leu Phe His Pro Ser Val Arg 
    450                 455


<210>  304
<211>  4841
<212>  DNA
<213>  Homo sapiens

<400>  304
agcacatcgc tgcgggctca caaagcggcc agacgctcgg cggcggcgtg tggcaggagc     60

gcaggggcgc gagccggcga tcagccttcc cggcgaccgt gccgcgggag ctcgagcaac    120

tcggactagg ggacccgggc cggcccccaa gatgccggcg atcgcggtgt tggcggcggc    180

cgccgcggcg tggtgcttcc tccaagtcga gagccggcac ctggacgcgc tcgccggagg    240

cgcgggcccc aaccacggca atttcctaga caatgaccag tggctgagca ccgtctccca    300

gtacgaccgg gacaagtact ggaaccgctt tcgagacgat gattatttca gaaactggaa    360

tcccaacaag ccctttgacc aagccctgga cccatccaag gacccctgcc tgaaggtaaa    420

atgcagccct cacaaagtgt gtgtgaccca ggactaccag accgccctgt gtgtcagccg    480

caagcacctg ctccccaggc aaaagaaggg gaacgtggcc cagaaacact gggttggacc    540

ttcgaatttg gtcaagtgca agccctgtcc cgtggcacag tcagccatgg tctgcggctc    600

agatggccac tcctacacat ccaagtgcaa attggagttc catgcttgtt ctactggcaa    660

aagcctcgcc accctctgtg atgggccctg tccctgtctc ccagagcctg agccaccaaa    720

gcacaaggca gaaaggagtg cctgcacaga caaggagttg cggaaccttg cctcccggct    780

gaaggattgg tttggagctc tccacgagga tgcgaacaga gtcatcaagc ccaccagctc    840

caacacagcc caaggcaggt ttgacactag catcctgccc atctgcaagg actccctggg    900

ctggatgttc aacaagttgg acatgaacta tgacctcctg cttgaccctt cagagatcaa    960

tgccatctac ctggataagt acgagccctg tatcaagcct cttttcaact cgtgtgactc   1020

cttcaaggat ggcaagcttt ctaacaatga gtggtgctac tgcttccaga agcctggagg   1080

tctcccttgc cagaatgaaa tgaacagaat tcagaagctg agtaagggga aaagcctgtt   1140

gggggccttc atacctcggt gtaatgagga gggctattac aaagccacac agtgccacgg   1200

cagcacgggg cagtgctggt gtgtggacaa atatgggaat gagttggctg gctccaggaa   1260

acagggtgct gtgagctgtg aagaggagca ggaaacctca ggggattttg gcagtggtgg   1320

gtccgtggtc ctgctggatg acctagaata tgaacgggag ctgggaccaa aggacaaaga   1380

ggggaagctg agggtgcaca cccgagccgt gacagaggat gatgaggatg aggatgatga   1440

caaagaggat gaggtcgggt acatatggta gtgcccacaa gaaagaggac acaagttttg   1500

cacaaaattg caagtcactt cctattcctg catttgtatc taagactcca aggcaccaag   1560

gtctcttctc cattgttgct ctctataccc gacctaaggt ttggaagaca actgcttgtt   1620

cccagaggat tctgattttg catatgtttg tatgggagaa agggtgttgt gttttttttt   1680

tgttgttgtt tattttttgg atagggaagt cattggctta attagagcct ccttcctttc   1740

tgtgagattt ttccaacaag catgtgattt acgtggaatt ctgacagtgc agggagcccc   1800

aaccctctta aatgtcaaag accctttttg attacccaca ctggtggtta ttacagcatg   1860

gttcccagcc ttacagtgtc taagtgcttc tcttgtgtcc tgtagatgtt gtgaaaaaga   1920

aaaaaacaaa aaatacacca cactgtactt tttccccctg cccccgttac tgccggtgat   1980

tattattaaa aattagtttt tttcacatca ttatatctgg cttcctataa acaacagcct   2040

taattcagtc aagactccct ttggggaatt cattttatta aaaattggtg tctggatact   2100

tccctgtaca tgcataaata tgcatgcatg tacagaaaga ctgtatgtgt gtgccttgca   2160

cacacaccca tacctctcag aaaaagtgtt tgggtatctt aaaaactcga aaaacaatga   2220

taaatttctc agcttgtcca gacctggaac aaaatttctg gaataagaaa tttgtattaa   2280

agtccttttt tgcactaaca gttggctctt gtagcctgca ggctgaggaa gtctcttctc   2340

tgtgcatcag cagagttact gaaagcctct gattgagaaa aaacctccgt ctgcctaaat   2400

cacttttctc gcagaagcca tgcgactccc acacgacacg ggcagcttca caagccatct   2460

ctttcatttc tgcttgaagc cccttggctg cagcaatcct gtctgccata ggtttcttcc   2520

ttccttacct actcaagggc tttttctaag gcatgcacac atatctcctg ttctctgaga   2580

gtaccatggt gttccttaaa agaagaaaat ttctaattct gaactcaatg ttttgctttt   2640

actccctttc tactgacaaa tcatgataag ggcacaaaag ctgtacagat tttttttttt   2700

aaccactcaa tcccaaatgg aggcctacaa agaacatcgt aataacacat ggaagcaaac   2760

cctgggtttt taagagcaaa ttctgtcccc ccctcactcc cccaagtgac aagatactaa   2820

tgaagaaagt tcttcaccat agtgtttgtt ttaactaaac tcattggagt ctagttccaa   2880

atttggtagg gtcatcatct ctacattcct taggatttct ctccctatca agctggccca   2940

gatacaagta ccaaacagta gtctctgaag ttcccccatt tccttcagta ccagtctata   3000

agctactgtc cgccactgat tttcatttat cagggtgtcc taatcagaat cagccaccca   3060

agcaagcctc tctggcccac atatctatct cttgccttcc cccatgaact tcagcctgtc   3120

cacacaaaag ccacataaac tcaagcaaga aatatgttca gccaaaacat gattatagtg   3180

gcagctgacc aatcccccat cccaaattga ccatttagat gtaccaactc accttaaatt   3240

agcatgttcc aatccagtcg gcattgcctg aatacagtag catcatacct atagttggtc   3300

ttagataaga aatgaactac ttgatatagc aaagtccttt ggcttcgtaa ataaccctga   3360

ggttttgtac ttactttccc cataggaaga cagaccatag gcaaactctg ttttgggatc   3420

tcaactccat cacctttgtt tcaatatttt ttttctctct tgaacaaaac tgagataatt   3480

tagaaaacag gtgcttaatt gcaataaaat tactatgaag tatattaaaa atcacgacat   3540

tgtaaaatct cactttagat catcaaagaa aaccattgtt actatctcct ttgagcttag   3600

gaaaatgtac aagagaacaa attaaaattg aaaaattgat ttcacttaga aaaacttcta   3660

ggaacagggt gaaccactga ttttaatttg cctaattatc ttatgacaag tatcaaatta   3720

agatgacact taaagatcct tagcattaac ttaatgatgg agaagagtgc tcaatagaca   3780

gttcccagta aggtaatgag atgccatttt cagagacatt ctaagaagat attttgattc   3840

attaaaacat taaataaaaa gccctcctca gattggaacc cccaaatcga tggagccaca   3900

ttaataatac ttttcatgcc tcactttgac atgacagcat tcgatttttt taaagatctt   3960

taatactttc catgagtact aaagattgta atgagttacc ttatccttag aagtagaatg   4020

tttgctttct tcttcttgga aatagtcctc caaaaagtcc acttgtacca gtgacaagaa   4080

gtcacttgta tagtgaccaa gtacacataa aatactgatt ataaaaatat tgtaataaac   4140

cacttcctca tttgatacag gtattaagct gaatcctcac taattcactt ttgaaaagtt   4200

cttaatgaac agttttattc ttattccatg aacagctctt ttaatacaat ttccttggta   4260

tccaacttaa atcccagaat tttgttccac catggttagt tatttgccat atgaatgtat   4320

tcttgtttct accaatattc taggcatgag aataccttaa tactgagttg gagattttgt   4380

atctgtttct cctcctttac gcccattttc ctacccacag cagcaaatga caacgtgtct   4440

gtccaggtct gtccccctgc tcatcccagg atgccactca catttttttc ttcttgttac   4500

cttgaccacg ctgtacagta acatccaaga gcccattcta cagtgggtgg ttttggtctt   4560

tttataactt tttctcaaag tcactgatgt ttgttcctgt taaatgtata gcattgtaat   4620

gagagcccat caaatcctga gtgtcagttt gttgtcccta ttgtagatga aatagtgatg   4680

tagcaaaaac ctagtaaatt ctgaatgctt ttccacgtag acttatctgg aatgtgaaca   4740

caactctttg gttaatagta aatgcttaac tgtagtcctg agtaggtgca tttctgtctg   4800

tctcaataaa ttttactttg tctgcaaaaa aaaaaaaaaa a                       4841


<210>  305
<211>  439
<212>  PRT
<213>  Homo sapiens

<400>  305

Met Pro Ala Ile Ala Val Leu Ala Ala Ala Ala Ala Ala Trp Cys Phe 
1               5                   10                  15


Leu Gln Val Glu Ser Arg His Leu Asp Ala Leu Ala Gly Gly Ala Gly 
            20                  25                  30


Pro Asn His Gly Asn Phe Leu Asp Asn Asp Gln Trp Leu Ser Thr Val 
        35                  40                  45


Ser Gln Tyr Asp Arg Asp Lys Tyr Trp Asn Arg Phe Arg Asp Asp Asp 
    50                  55                  60


Tyr Phe Arg Asn Trp Asn Pro Asn Lys Pro Phe Asp Gln Ala Leu Asp 
65                  70                  75                  80


Pro Ser Lys Asp Pro Cys Leu Lys Val Lys Cys Ser Pro His Lys Val 
                85                  90                  95


Cys Val Thr Gln Asp Tyr Gln Thr Ala Leu Cys Val Ser Arg Lys His 
            100                 105                 110


Leu Leu Pro Arg Gln Lys Lys Gly Asn Val Ala Gln Lys His Trp Val 
        115                 120                 125


Gly Pro Ser Asn Leu Val Lys Cys Lys Pro Cys Pro Val Ala Gln Ser 
    130                 135                 140


Ala Met Val Cys Gly Ser Asp Gly His Ser Tyr Thr Ser Lys Cys Lys 
145                 150                 155                 160


Leu Glu Phe His Ala Cys Ser Thr Gly Lys Ser Leu Ala Thr Leu Cys 
                165                 170                 175


Asp Gly Pro Cys Pro Cys Leu Pro Glu Pro Glu Pro Pro Lys His Lys 
            180                 185                 190


Ala Glu Arg Ser Ala Cys Thr Asp Lys Glu Leu Arg Asn Leu Ala Ser 
        195                 200                 205


Arg Leu Lys Asp Trp Phe Gly Ala Leu His Glu Asp Ala Asn Arg Val 
    210                 215                 220


Ile Lys Pro Thr Ser Ser Asn Thr Ala Gln Gly Arg Phe Asp Thr Ser 
225                 230                 235                 240


Ile Leu Pro Ile Cys Lys Asp Ser Leu Gly Trp Met Phe Asn Lys Leu 
                245                 250                 255


Asp Met Asn Tyr Asp Leu Leu Leu Asp Pro Ser Glu Ile Asn Ala Ile 
            260                 265                 270


Tyr Leu Asp Lys Tyr Glu Pro Cys Ile Lys Pro Leu Phe Asn Ser Cys 
        275                 280                 285


Asp Ser Phe Lys Asp Gly Lys Leu Ser Asn Asn Glu Trp Cys Tyr Cys 
    290                 295                 300


Phe Gln Lys Pro Gly Gly Leu Pro Cys Gln Asn Glu Met Asn Arg Ile 
305                 310                 315                 320


Gln Lys Leu Ser Lys Gly Lys Ser Leu Leu Gly Ala Phe Ile Pro Arg 
                325                 330                 335


Cys Asn Glu Glu Gly Tyr Tyr Lys Ala Thr Gln Cys His Gly Ser Thr 
            340                 345                 350


Gly Gln Cys Trp Cys Val Asp Lys Tyr Gly Asn Glu Leu Ala Gly Ser 
        355                 360                 365


Arg Lys Gln Gly Ala Val Ser Cys Glu Glu Glu Gln Glu Thr Ser Gly 
    370                 375                 380


Asp Phe Gly Ser Gly Gly Ser Val Val Leu Leu Asp Asp Leu Glu Tyr 
385                 390                 395                 400


Glu Arg Glu Leu Gly Pro Lys Asp Lys Glu Gly Lys Leu Arg Val His 
                405                 410                 415


Thr Arg Ala Val Thr Glu Asp Asp Glu Asp Glu Asp Asp Asp Lys Glu 
            420                 425                 430


Asp Glu Val Gly Tyr Ile Trp 
        435


<210>  306
<211>  3837
<212>  DNA
<213>  Homo sapiens

<400>  306
atcgcctcct ccctccccaa gatggcgtcc ttgctgcagt cggaccgggt tctctatcta     60

gtccagggag aaaagaaggt tcgggccccg ctctcgcaac tctacttctg ccgctattgt    120

agcgaactgc ggtcgctgga atgtgtgtct cacgaggtgg actcccatta ttgtcccagt    180

tgtttagaaa atatgccatc ggctgaagcc aaactaaaaa agaatagatg tgccaattgt    240

tttgactgtc ctggctgcat gcacaccctc tctactcggg ccacgagcat ctccacacag    300

cttccagatg acccagccaa gaccaccatg aagaaagcct attacctggc atgtggattt    360

tgtcgctgga cgtctagaga tgtgggcatg gcagacaaat ctgtagctag tggcggttgg    420

caggaacctg aaaatcctca cacacaacgg atgaacaaat tgattgaata ttaccagcag    480

cttgctcaga aagagaaggt tgagcgagat cgcaagaaac tggcacgacg tagaaactat    540

atgcctctgg ctttttcgga caaatatggt cttggaacca ggcttcagcg accacgagct    600

ggtgcatcca tcagtaccct tgccggactt tcccttaaag aaggagagga tcagaaagag    660

ataaagattg agccagctca ggctgtggat gaagtggaac ctctacctga agactattat    720

acaagaccag taaatttaac agaggtaaca acccttcagc agcgtctgtt acagcctgac    780

ttccagccag tctgtgcttc acagctctat cctcgccaca aacatcttct gatcaaacgg    840

tccctgcgct gccgtaaatg tgaacataat ttgagcaagc cagaatttaa cccaacgtca    900

atcaaattca aaatccagct ggtcgctgtc aattatattc cagaagtgag aatcatgtca    960

attcccaacc ttcgctacat gaaggagagc caggtcctcc tgactcttac aaatccagtt   1020

gagaacctca cccatgtgac tctcttcgag tgtgaggagg gggaccctga tgatatcaac   1080

agcactgcta aggtggtggt gcctcccaaa gagctcgttt tagctggcaa ggatgcagca   1140

gcagagtacg atgagttggc agaacctcaa gactttcagg acgatcctga cattatagcc   1200

ttcagaaagg ccaacaaagt gggtattttc atcaaagtta caccacagcg tgaggagggt   1260

gaagtgaccg tgtgcttcaa gatgaagcat gattttaaaa acctggcagc ccccattcgc   1320

cccattgaag aaagtgacca gggaacagaa gtcatctggc tcacccagca tgtggaactt   1380

agcttgggcc cacttcttcc ttaaaaggtt ccactggagg gcagatccca aaggacagta   1440

tcaccgtaaa cctgcgttaa aatgtggaag ctgctgcttc attaggcctt gtttataacg   1500

atgtacccat gcactacgga attctattgc taagaaagtg ggagcatagg caaggcattg   1560

ggaacacagg gtagctgctg ttgctcttgc tctcacccct gttgacacca gtaagtctgt   1620

gtcttcctca ctgaaccctg cacgttgagt aacagcagca taattccatc ctaggaaagg   1680

gggatgggtg ttccttggaa atggcattgt atttaccacc tgagaaactc tgtactgtct   1740

cttgatctga tctcactaag gatcacaatg tcacagatga aacttaaatg ataacccaaa   1800

ggtagacctg ctgttaatga tccagcattg gtcacaatgt accaactgct ttctgcattc   1860

cgttaaatat catctaacag tctaaaacat atcccttcat tgccataatg gctgccattt   1920

tgccatagat ttccatataa ctgaaaaact gaattgtcac tttatcttta gtatcatgat   1980

gattggaaaa acctgtgaag ttgttaaggc actctcattt gccctctttt tctaagtgaa   2040

tacaggacac gtattagttg ttcttaattt ttttcccagt aaaatatgga tcttttaaga   2100

agaatttgag aagcaaacaa ttacatgtca tgtcaagggg gtagcagatt ccattcgttt   2160

tcaatattgc cacaataccc agggattaat gctgccacag gggggcaatc tttatttgtc   2220

ttacttccta ccccttccct gttctgcctc tttaactcag ttaagttgtt ctgtttggga   2280

cctggaaaag aacccaaaga aaacctgagt ggacaggttc atttctggaa tgcagaaaac   2340

attttaaagg ctagattttt agaatattct caactagcat tctttccatt gatttgaagg   2400

ggaaattaac tattataatc tcttgaatcc aaaactggat attaagaact ttccccctta   2460

ctaagtttaa gacttttgtc atgtggtgag tcaaataaga ccattttgat tgtaaaccat   2520

aaaatagttc agcaagtagc ccacagttct ggcctaacag cagacttgct gttttcactt   2580

ggtatcctgg agttgggttg ctaaccttaa tttctatgat gttttctaaa atgaaacttg   2640

ataaagtaga ccaccagctg caccgtgttt tctgtaaaag tattgttagt aagtggccaa   2700

gagacttgag gaaaatacag attttttgtt taccttggtc ttgttttaag tcttaaaaaa   2760

ttaaagataa cattataatg tagaatacag atgggacata gtccttgtaa gcttcccttg   2820

aaaatgtttt aaatatttag gaagctttta aaagacacta aattgtactc taaaagacac   2880

taaattgtac taattgtaca aaggtcaagc caattttatg aaacagtcct acagagtaat   2940

atatgtgatg cagtgtaaga aggaaaatac tcatctctaa cattatggta ataacattta   3000

gcctcttagg agttggagca gggggatggg taattacaga tttgcagact atagaaagag   3060

tttcattttt ttgtgacccc acagagtctc aaatttttat tccactacct gctagagcct   3120

actgtgaaat cactgctcca tatttgccag tggaggaaat gggcatagag tagagaatag   3180

cttcatatgt ttacacgttt gcatagacta cacacatgtc atgcgtttat ggcaggtagc   3240

tggtatttat tccccaaagt aataatgttg aagtatgggt ctcatcattc ccatacacag   3300

aaacacaaaa cactttgatc ataaactttt ttcttcagaa gccaaactaa cttgcagaat   3360

aatagagcca ctggtttaat gtttcctcaa gataggtttt agtgtaagct agtattctgt   3420

gtgttcgtag aaatgattca atacctgcag ctggtgaatt aggaattgta tttgttgcct   3480

tttttatatt agatgaggtg caaaaatttt aatgctagtc agtatgcacc accacaggaa   3540

agttagatcc cattagcact tgagactaca gctttggaaa cttaggctaa gttaatttgg   3600

atttgttact tgattcacct actgaccttt tcttttgttt gaagtgctta tcagcataat   3660

gagctaagtg tcatgcatat ttgtgaagaa acacccttgt ttggtccctt ttgggacaga   3720

gaggtactcc ttgatcttta tgaatgaccg gttactgttt tgccttattg cttaacttaa   3780

tgtagtgaaa taaagcagac caagcttgaa aaaaaaaaaa aaaaaaaaaa aaaaaaa      3837


<210>  307
<211>  460
<212>  PRT
<213>  Homo sapiens

<400>  307

Met Ala Ser Leu Leu Gln Ser Asp Arg Val Leu Tyr Leu Val Gln Gly 
1               5                   10                  15


Glu Lys Lys Val Arg Ala Pro Leu Ser Gln Leu Tyr Phe Cys Arg Tyr 
            20                  25                  30


Cys Ser Glu Leu Arg Ser Leu Glu Cys Val Ser His Glu Val Asp Ser 
        35                  40                  45


His Tyr Cys Pro Ser Cys Leu Glu Asn Met Pro Ser Ala Glu Ala Lys 
    50                  55                  60


Leu Lys Lys Asn Arg Cys Ala Asn Cys Phe Asp Cys Pro Gly Cys Met 
65                  70                  75                  80


His Thr Leu Ser Thr Arg Ala Thr Ser Ile Ser Thr Gln Leu Pro Asp 
                85                  90                  95


Asp Pro Ala Lys Thr Thr Met Lys Lys Ala Tyr Tyr Leu Ala Cys Gly 
            100                 105                 110


Phe Cys Arg Trp Thr Ser Arg Asp Val Gly Met Ala Asp Lys Ser Val 
        115                 120                 125


Ala Ser Gly Gly Trp Gln Glu Pro Glu Asn Pro His Thr Gln Arg Met 
    130                 135                 140


Asn Lys Leu Ile Glu Tyr Tyr Gln Gln Leu Ala Gln Lys Glu Lys Val 
145                 150                 155                 160


Glu Arg Asp Arg Lys Lys Leu Ala Arg Arg Arg Asn Tyr Met Pro Leu 
                165                 170                 175


Ala Phe Ser Asp Lys Tyr Gly Leu Gly Thr Arg Leu Gln Arg Pro Arg 
            180                 185                 190


Ala Gly Ala Ser Ile Ser Thr Leu Ala Gly Leu Ser Leu Lys Glu Gly 
        195                 200                 205


Glu Asp Gln Lys Glu Ile Lys Ile Glu Pro Ala Gln Ala Val Asp Glu 
    210                 215                 220


Val Glu Pro Leu Pro Glu Asp Tyr Tyr Thr Arg Pro Val Asn Leu Thr 
225                 230                 235                 240


Glu Val Thr Thr Leu Gln Gln Arg Leu Leu Gln Pro Asp Phe Gln Pro 
                245                 250                 255


Val Cys Ala Ser Gln Leu Tyr Pro Arg His Lys His Leu Leu Ile Lys 
            260                 265                 270


Arg Ser Leu Arg Cys Arg Lys Cys Glu His Asn Leu Ser Lys Pro Glu 
        275                 280                 285


Phe Asn Pro Thr Ser Ile Lys Phe Lys Ile Gln Leu Val Ala Val Asn 
    290                 295                 300


Tyr Ile Pro Glu Val Arg Ile Met Ser Ile Pro Asn Leu Arg Tyr Met 
305                 310                 315                 320


Lys Glu Ser Gln Val Leu Leu Thr Leu Thr Asn Pro Val Glu Asn Leu 
                325                 330                 335


Thr His Val Thr Leu Phe Glu Cys Glu Glu Gly Asp Pro Asp Asp Ile 
            340                 345                 350


Asn Ser Thr Ala Lys Val Val Val Pro Pro Lys Glu Leu Val Leu Ala 
        355                 360                 365


Gly Lys Asp Ala Ala Ala Glu Tyr Asp Glu Leu Ala Glu Pro Gln Asp 
    370                 375                 380


Phe Gln Asp Asp Pro Asp Ile Ile Ala Phe Arg Lys Ala Asn Lys Val 
385                 390                 395                 400


Gly Ile Phe Ile Lys Val Thr Pro Gln Arg Glu Glu Gly Glu Val Thr 
                405                 410                 415


Val Cys Phe Lys Met Lys His Asp Phe Lys Asn Leu Ala Ala Pro Ile 
            420                 425                 430


Arg Pro Ile Glu Glu Ser Asp Gln Gly Thr Glu Val Ile Trp Leu Thr 
        435                 440                 445


Gln His Val Glu Leu Ser Leu Gly Pro Leu Leu Pro 
    450                 455                 460


<210>  308
<211>  1993
<212>  DNA
<213>  Homo sapiens

<400>  308
aaccaatcct cacaacagga ctgggagaca ggtgttacct ttcccacttt acagagaatg     60

aaacagagtg gcaaagcctc cgaaggaccc tacacttcgg acatcgcaaa gcaggatctg    120

agtcccggct cctctgtcca aacctacttg ctaggctttc tttcccatgt ctactctata    180

gctggaaagg tcgtggagga cacattttag gccaaccctc tcggtttaca atccagagag    240

gggagaccct cagaagccaa gcgacatgtc cacggctacg cggcgagtgt gtggcaacgt    300

ggaaggggag cccgagacgc cctggtctct cccttctctc gcaggttcct ttctccccga    360

acgcagcccg caggggacgc tggaggagga gctgagctgg agttgccggg gccccgggac    420

cgggcgttcc gggggcggtc cccagcagcc gcgcattcca gagccagcag cgcgtcctgg    480

ccgctcctgc gctctcccgc ctcccggggc tcggaggagc cggggcacgt tccaggagct    540

gcctagggct gaggttccag gcctgggggt cgcttccagc tgccagatcc cgtgcagtcc    600

tggggaccct gagaagcacc gagccatccc tgacccagga actttccgca gactcgccgc    660

catctgggag tgaagcaaca tggatgcagt cagccaagtc cccatggaag tcgtgcttcc    720

caagcacatc ctggatatct gggttattgt cctcatcatc ctggccacca ttgtcatcat    780

gacctcgttg ttgctgtgcc cagccactgc agtaatcatc tatcgcatgc ggactcatcc    840

gatccttagt ggggctgttt gagagcctcc caagagggcc gggtgaggga tgaggacagg    900

catcctatcc ccagcctctt cctgtcttca gaaaagcagc aggagggact ttggggcatg    960

gacctgagtt ctggttttga ttctgccacg agccagctgt gtgaatttgg tcaagggacc   1020

taactctctg agttccaggt tccttatctt tcaaatgggg atggtgatcc ctgccctttc   1080

tacctcatag ggatgtgaga accacctgac ttagtggatg tgaaagctgt ttgtgatcag   1140

taaagctacc acagatataa gggtgttatg ctgaatcctg agaagctttc aagaaccaga   1200

gaacctgatt gctgatgatg gccttaaagg tggtgaggga gatactgggg gcagagcaga   1260

ctttgccagt gcccctcagg tcaaaccaag ccaagagcac cctgtcccca ttccaagggg   1320

ccagcagcac tttggcccaa agtattttct ttaaggtgcc attccttcat gttttctcag   1380

tttggagggt gatgggtaga gctttccaga accttctcca ttccagaatc tctgcccctg   1440

tgtaatctga aggaaggctg tgccatcttt gggcactgcc aagggagttg gggtgatggg   1500

cttctttctg cactggagtc tcacatctgt tagctttgac actcaagcaa tgttggaaaa   1560

tgcagggtga ctgagttccc tgcccagctt tcgggatctc tggcccccat ccccttgtgt   1620

gtgtccctct gcccagctcc tgctgtaatt agctccacgt gtaccccctt cactccctcc   1680

caccagctct gcagccagcc tatggcaatt atattttaag aggtgttccc aggacttttg   1740

ggacctacta aaacaatgat ggttatttta gatgtgatga tttatattta tgtagagata   1800

tttctggacc actcaagctc ttcgatacca aaatcaggag catcttggga tttattaaat   1860

tatgtaagaa gatagcacag atatcgggat attattgtgt gaaaatgctg cttttacttt   1920

gatgtgatct cattgatgta cacaaccaag ttccaataaa gtgctagaat gtgcaaaaaa   1980

aaaaaaaaaa aaa                                                      1993


<210>  309
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  309

Met Ser Thr Ala Thr Arg Arg Val Cys Gly Asn Val Glu Gly Glu Pro 
1               5                   10                  15


Glu Thr Pro Trp Ser Leu Pro Ser Leu Ala Gly Ser Phe Leu Pro Glu 
            20                  25                  30


Arg Ser Pro Gln Gly Thr Leu Glu Glu Glu Leu Ser Trp Ser Cys Arg 
        35                  40                  45


Gly Pro Gly Thr Gly Arg Ser Gly Gly Gly Pro Gln Gln Pro Arg Ile 
    50                  55                  60


Pro Glu Pro Ala Ala Arg Pro Gly Arg Ser Cys Ala Leu Pro Pro Pro 
65                  70                  75                  80


Gly Ala Arg Arg Ser Arg Gly Thr Phe Gln Glu Leu Pro Arg Ala Glu 
                85                  90                  95


Val Pro Gly Leu Gly Val Ala Ser Ser Cys Gln Ile Pro Cys Ser Pro 
            100                 105                 110


Gly Asp Pro Glu Lys His Arg Ala Ile Pro Asp Pro Gly Thr Phe Arg 
        115                 120                 125


Arg Leu Ala Ala Ile Trp Glu 
    130                 135


<210>  310
<211>  546
<212>  DNA
<213>  Homo sapiens

<400>  310
atggaagcca tgaatgttga gaaagcctca gcagatggga acttgccaga ggtgatctct     60

aacatcaagg agactctgaa gatagtgtcc aggacaccag ttaacatcac tatggcaggg    120

gactctggca atgggatgtc caccttcatc agtgcccttc gaaacacagg acatgagggt    180

aaggcctcac ctcctactga gctggtaaaa gctacccaaa gatgtgcctc ctatttctct    240

tcccactttt caaatgtggt gttgtgggac ctgcctggca cagggtctgc caccacaacc    300

ctggagaact acctgatgga aatgcagttc aaccggtatg acttcatcat ggttgcatct    360

gcacaattca gcatgaatca tgtgatgctt gccaaaaccg ctgaggacat gggaaagaag    420

ttctacattg tctggaccaa gctagacatg gacctcagca caggtgccct cccagaagtg    480

cagctactgc agatcagaga aaatgtcctg gaaaatctcc agaaggagcg ggtatgtgaa    540

tactaa                                                               546


<210>  311
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  311

Met Glu Ala Met Asn Val Glu Lys Ala Ser Ala Asp Gly Asn Leu Pro 
1               5                   10                  15


Glu Val Ile Ser Asn Ile Lys Glu Thr Leu Lys Ile Val Ser Arg Thr 
            20                  25                  30


Pro Val Asn Ile Thr Met Ala Gly Asp Ser Gly Asn Gly Met Ser Thr 
        35                  40                  45


Phe Ile Ser Ala Leu Arg Asn Thr Gly His Glu Gly Lys Ala Ser Pro 
    50                  55                  60


Pro Thr Glu Leu Val Lys Ala Thr Gln Arg Cys Ala Ser Tyr Phe Ser 
65                  70                  75                  80


Ser His Phe Ser Asn Val Val Leu Trp Asp Leu Pro Gly Thr Gly Ser 
                85                  90                  95


Ala Thr Thr Thr Leu Glu Asn Tyr Leu Met Glu Met Gln Phe Asn Arg 
            100                 105                 110


Tyr Asp Phe Ile Met Val Ala Ser Ala Gln Phe Ser Met Asn His Val 
        115                 120                 125


Met Leu Ala Lys Thr Ala Glu Asp Met Gly Lys Lys Phe Tyr Ile Val 
    130                 135                 140


Trp Thr Lys Leu Asp Met Asp Leu Ser Thr Gly Ala Leu Pro Glu Val 
145                 150                 155                 160


Gln Leu Leu Gln Ile Arg Glu Asn Val Leu Glu Asn Leu Gln Lys Glu 
                165                 170                 175


Arg Val Cys Glu Tyr 
            180


<210>  312
<211>  3104
<212>  DNA
<213>  Homo sapiens

<400>  312
ctcgcggaca ggaagcagga gagtttgcca atagggatgt gacagcggtt cccattaagc     60

ggtgatggtg gttttgggac ctgataatcg agctgggagt cagaggcggg atgtgtgcgg    120

tgaaggatgt tttgataccc ccatataaaa taatctgtct gtcatgggag cccccacgtc    180

ctctgaaata gttcagctct gtctgcatga cttgtcctgg gactgaggaa aatttaccag    240

tcatctggcc ttttggaaga gcaaaaaatg atgaagtccc aggggttagt atcattcaag    300

gatgtggctg tggatttcac ccaggaggag tggcagcaac ttgacccttc tcagaggacc    360

ctgtacaggg atgtgatgct ggagaactac agccacctgg tctcaatggg gtatccagtt    420

tccaaaccag atgtcatctc caagttggaa caaggagaag agccatggat cataaaggga    480

gacatatcaa attggatcta tccagatgaa tatcaggcag atgggagaca agacaggaag    540

agtaaccttc acaactccca gtcatgtatt ttggggacag tttccttcca tcataagata    600

ctgaaaggag tcacaaggga tggttcattg tgctccattt taaaagtctg tcaaggtgat    660

ggtcagctgc agagatttct agagaatcaa gacaaactct tcaggcaggt cacatttgtt    720

aacagcaaaa cagtgactga ggcatcaggg cataaatata atccactggg gaaaatattt    780

caagagtgca tagaaacaga tatatcaata cagagattcc ataaatatga tgcttttaaa    840

aagaacttaa aaccaaatat tgacctaccg agttgttata agagcaattc aagaaaaaaa    900

cctgatcaga gttttggagg tggaaaatca tctagccaga gtgagcccaa ttctaatctt    960

gagaagattc acaatggagt aatacctttt gatgataatc agtgtggaaa cgtttttaga   1020

aatacacaat cccttattca atatcagaat gtggaaacta aagagaaaag ctgtgtatgt   1080

gttacatgtg gaaaagcctt tgctaagaag tcacaactca ttgtacatca aagaattcat   1140

actggaaaga aaccatatga ttgtggtgca tgcggaaaag ccttcagtga gaagtttcat   1200

cttgttgtac atcagagaac tcatactggg gagaaacctt atgattgttc tgaatgtgga   1260

aaagccttct ctcagaaatc gtcccttatt atacatcaga gagttcacac tggggaaaaa   1320

ccctatgaat gtagtgaatg cgggaaagcc ttctcccaga aatcacccct cattatacat   1380

cagagaatac atactgggga aaaaccctat gaatgtagag agtgtgggaa ggccttttcc   1440

cagaagtcac agctgattat acaccacaga gctcatactg gagagaagcc gtatgagtgt   1500

accgaatgtg ggaaagcctt ctgtgagaag tcccacctca ttatacataa aagaattcac   1560

actggtgaga aaccctacaa atgtgctcaa tgtgaggaag ccttcagcag gaagacagaa   1620

ctcattacac atcagttagt tcatactggg gaaaaacctt atgaatgtac tgaatgtgga   1680

aagacattct cccgcaagtc acagctcatc atacatcaga gaacacatac tggagaaaaa   1740

ccctataaat gtagtgaatg tggcaaagcc ttctgccaga agtcacatct cattggacat   1800

cagagaattc acacaggaga aaaaccttat atatgtactg aatgtgggaa agccttctct   1860

cagaagtccc accttccggg acaccagcga attcatacag gagagaaacc ttacatatgt   1920

gctgaatgtg gaaaggcctt ttctcagaag tcagaccttg ttttacatca gaggattcat   1980

actggggaaa gaccctatca atgtgctata tgtgggaagg ccttcatcca gaagtcacaa   2040

ctaactgtac accagagaat tcacacagtg gtaaaatcat aatgaactgg ccacagaaaa   2100

gccttagtat tagctcaagc cttaataatt actagaaacc caattaattt gataagcttg   2160

gggacaacat cccaatagat aaaaattttt aagggaattt gtttctagtt tggtgatgcc   2220

taacttttcc agcaaagatg atggaaaata gttatataaa tgaagaacat ttttaatatg   2280

gcatgtaaag cttttaaagt tatgaactca gtgatcagca cagcaagtta agcatacaga   2340

atattgtcaa gttgcatatt ccttatacta caaaatgata atcagccatt gtgaaactgc   2400

taatattagc ttgtcataat tatggccata aactaatttt tctataaaag acgtggaaga   2460

aagcttaagt aaacaataaa ataaaaccta tacactattt taagaagggg cttgagcatg   2520

acccctaaag ctacatgtaa agttcttgta caaaaaatgg aatgataggt tgatcagatt   2580

cagtaaagtt gatctgtatg cattttccca tctcaagcat ataagttgac ctgcatctct   2640

ggaaggacct tgagattgat gcattttgag caggtctccc ttttactctt cccaactggg   2700

aacttggagc tgaaaaacat tggcactgag gccagatggc cttgggttta atcctggctc   2760

agtgcctcac agattgtgtg actttaggca aacatacttc tcctagctga gtatttttta   2820

tcagtaagta caaatacaat gcagagctca ttttcagtta atattagtac tttttaaatc   2880

tttactctct atcttgaagc attagatgtt aagactaatg tgtaaaaacc acgtctgagc   2940

ttgcttttcc ctctggacac tctgcttttg attgcctatc cctataagtg gctcatttta   3000

ctgtcttctg atcctggtgg ccttattttt gctatgttaa ggttgtgttt tttaatactt   3060

ggatttattt tcatatactt acataaaccg tggtgattgc acat                    3104


<210>  313
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  313

Met Met Lys Ser Gln Gly Leu Val Ser Phe Lys Asp Val Ala Val Asp 
1               5                   10                  15


Phe Thr Gln Glu Glu Trp Gln Gln Leu Asp Pro Ser Gln Arg Thr Leu 
            20                  25                  30


Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser His Leu Val Ser Met Gly 
        35                  40                  45


Tyr Pro Val Ser Lys Pro Asp Val Ile Ser Lys Leu Glu Gln Gly Glu 
    50                  55                  60


Glu Pro Trp Ile Ile Lys Gly Asp Ile Ser Asn Trp Ile Tyr Pro Asp 
65                  70                  75                  80


Glu Tyr Gln Ala Asp Gly Arg Gln Asp Arg Lys Ser Asn Leu His Asn 
                85                  90                  95


Ser Gln Ser Cys Ile Leu Gly Thr Val Ser Phe His His Lys Ile Leu 
            100                 105                 110


Lys Gly Val Thr Arg Asp Gly Ser Leu Cys Ser Ile Leu Lys Val Cys 
        115                 120                 125


Gln Gly Asp Gly Gln Leu Gln Arg Phe Leu Glu Asn Gln Asp Lys Leu 
    130                 135                 140


Phe Arg Gln Val Thr Phe Val Asn Ser Lys Thr Val Thr Glu Ala Ser 
145                 150                 155                 160


Gly His Lys Tyr Asn Pro Leu Gly Lys Ile Phe Gln Glu Cys Ile Glu 
                165                 170                 175


Thr Asp Ile Ser Ile Gln Arg Phe His Lys Tyr Asp Ala Phe Lys Lys 
            180                 185                 190


Asn Leu Lys Pro Asn Ile Asp Leu Pro Ser Cys Tyr Lys Ser Asn Ser 
        195                 200                 205


Arg Lys Lys Pro Asp Gln Ser Phe Gly Gly Gly Lys Ser Ser Ser Gln 
    210                 215                 220


Ser Glu Pro Asn Ser Asn Leu Glu Lys Ile His Asn Gly Val Ile Pro 
225                 230                 235                 240


Phe Asp Asp Asn Gln Cys Gly Asn Val Phe Arg Asn Thr Gln Ser Leu 
                245                 250                 255


Ile Gln Tyr Gln Asn Val Glu Thr Lys Glu Lys Ser Cys Val Cys Val 
            260                 265                 270


Thr Cys Gly Lys Ala Phe Ala Lys Lys Ser Gln Leu Ile Val His Gln 
        275                 280                 285


Arg Ile His Thr Gly Lys Lys Pro Tyr Asp Cys Gly Ala Cys Gly Lys 
    290                 295                 300


Ala Phe Ser Glu Lys Phe His Leu Val Val His Gln Arg Thr His Thr 
305                 310                 315                 320


Gly Glu Lys Pro Tyr Asp Cys Ser Glu Cys Gly Lys Ala Phe Ser Gln 
                325                 330                 335


Lys Ser Ser Leu Ile Ile His Gln Arg Val His Thr Gly Glu Lys Pro 
            340                 345                 350


Tyr Glu Cys Ser Glu Cys Gly Lys Ala Phe Ser Gln Lys Ser Pro Leu 
        355                 360                 365


Ile Ile His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Arg 
    370                 375                 380


Glu Cys Gly Lys Ala Phe Ser Gln Lys Ser Gln Leu Ile Ile His His 
385                 390                 395                 400


Arg Ala His Thr Gly Glu Lys Pro Tyr Glu Cys Thr Glu Cys Gly Lys 
                405                 410                 415


Ala Phe Cys Glu Lys Ser His Leu Ile Ile His Lys Arg Ile His Thr 
            420                 425                 430


Gly Glu Lys Pro Tyr Lys Cys Ala Gln Cys Glu Glu Ala Phe Ser Arg 
        435                 440                 445


Lys Thr Glu Leu Ile Thr His Gln Leu Val His Thr Gly Glu Lys Pro 
    450                 455                 460


Tyr Glu Cys Thr Glu Cys Gly Lys Thr Phe Ser Arg Lys Ser Gln Leu 
465                 470                 475                 480


Ile Ile His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Ser 
                485                 490                 495


Glu Cys Gly Lys Ala Phe Cys Gln Lys Ser His Leu Ile Gly His Gln 
            500                 505                 510


Arg Ile His Thr Gly Glu Lys Pro Tyr Ile Cys Thr Glu Cys Gly Lys 
        515                 520                 525


Ala Phe Ser Gln Lys Ser His Leu Pro Gly His Gln Arg Ile His Thr 
    530                 535                 540


Gly Glu Lys Pro Tyr Ile Cys Ala Glu Cys Gly Lys Ala Phe Ser Gln 
545                 550                 555                 560


Lys Ser Asp Leu Val Leu His Gln Arg Ile His Thr Gly Glu Arg Pro 
                565                 570                 575


Tyr Gln Cys Ala Ile Cys Gly Lys Ala Phe Ile Gln Lys Ser Gln Leu 
            580                 585                 590


Thr Val His Gln Arg Ile His Thr Val Val Lys Ser 
        595                 600


<210>  314
<211>  2456
<212>  DNA
<213>  Homo sapiens

<400>  314
ggctcagcgc ctggcgagtc ctccgcttgt actgagacgc ctgggatctc aaaatggcgg     60

ccccgtgcgg aaacagcgtc tgggagcagt catgttgcct cctgaacaaa gccgctgaag    120

atgaagaatg ggcaaaatcg ccccatacgg aacagcgcag cctcgggagc ccgttacctg    180

gctcgcgaac acgaagcggg agagttcgcc aatatggatg tgacagcggt tcccattaag    240

cggtgatagg atttttggga cctgataatc aagctaggga cctgattcct cagacctctg    300

ccctatcgga agggaagcag aaaatgatca ggtctcaggg tccagtgtca tttgaggatg    360

tggctgtgga tttcacccag gaggagtggc agcaactgga ctatgctcag aggaccctgt    420

acagggatgt gatgctggag atctatagcc acctggtctc aatgggatat ccagtttcca    480

aaccagatgt catctccaag ttggaacaag gagaagagcc atggatcata aagagacaca    540

taccaaattg gatctatcca ggtgaaaatg tggcagatgg gagacaagaa aaataaatgc    600

tcaagagtag acttgacacc cctcaactgg atatatttag agatgttttc ttccataagg    660

agacactgga aagtattaca aggggtcatt cattgtactc cattttaaaa gtctggcaag    720

gtgatgacca gctggagaga gatcaggaaa actgagacaa atttgtcagg caagttgtag    780

tcatcaacaa caaaagaata tctgaagagt caggtcatcc atataatata tttggaaaaa    840

tatttcatga ctgcacagac ctagatactt caaaacaaag actgtgtaag tgtgattcat    900

ttgaaaagac cttgaaacca aatattaacc tagtgagtta taataggaat tttgcaagaa    960

aaaacattga tgagaatttt agatgtggga aaacacctag ctacagttct tgctattcta   1020

agcatgaaaa aaatcatagt ggaatgatac actgtgaagc tactcattgt ggaaagattc   1080

ttagcaataa acaatctctt attcattatg tgaatgttga aactggggag aagacctatg   1140

tatgtgttga atgtggaaaa tcctttctca agaagtcaca gattattata catcaaagaa   1200

ttcatactgg agagaaacct tatgattgtg gtgcatgtgg aaaagccttc agtgagaagt   1260

cacaccttat tgcacatcag agaactcata ctggggagaa accttatgat tgttctgaat   1320

gtggaaaagg cttttctcag aaatcatccc tcattataca tcagagagtt cacactgggg   1380

aaaaaccata tgaatgtagt gaatgtgaga aagccttctc ccagaaatca cccctcatta   1440

tacatcagag aatacatact ggggaaaagc cctatgaatg tagagtgtgg gaaagccttt   1500

tcccagagtc acagctgatt atacatcaca gagctcatac tggagagaag ccatgtaagt   1560

gtactgaatg tgggaaagca ttctgtttta tacattaaag agttcacact ggtgagaaac   1620

cctacaaatg tgctcaatgt gaggaagcct tcagcaggaa gtcagaactc attatacatc   1680

agataattca tactggggag aaaccgtatg aatgtacaga atgtgggaaa acattctctc   1740

gcaagtcaca actcatcata catcagagaa cccacactgg agagaaaccc tataaatgta   1800

ccaaatgtgg aaaatccttc tgtcagcagt cacatctcat tggacatcag agaattcaca   1860

cgggagaaca accttatgta tgttctgaat gtgggaaagc cttctctcag aagtctcacc   1920

tcccagggca ttggtgaatt catacaggag agaaacctta catatgtgct gaatgtggaa   1980

aggccttttc tcagaagtca gaccttgttg tacatcagat aattcatact ggagagaaac   2040

ctgatcgatg tactgtatgt gggaaggcct tcatccagaa gtcccaactc actgtacatc   2100

agagaattca tacactaatg aaatcataag aatggtctga acacagaaaa gccttcaggg   2160

tcagttcaag ccttaataga tagtgcaaca accaatggat ttgatgattt tggggactac   2220

atctttgttg ataaaatttt acaagtgaag tcatgttcct aatgtatttc attctttatc   2280

aaagataata gagaagtcaa tacgtaaatg atggacattt tcactatggc atataaaagt   2340

ttttaaattg agaaatgaat gattagcata acagaacgaa ttgcatgtac atctcttttg   2400

aagttatgtg ctcctgatta tactacataa caatcagata tgtgtaagat tgttaa       2456


<210>  315
<211>  2338
<212>  DNA
<213>  Homo sapiens

<400>  315
ctcaacgtcg aaccgaaggc gacacccacc caactcctcc ctctccgccc catagtccac     60

ccaacacttg cagcccctcc agagaaaaag cccagcggaa gaggactccg gaaaagtgac    120

tatctcggaa gaccagggta gagctcccgg gagaaaaagg cgaagatccc cggccccgga    180

tcgccatccc cttccctggc accagcttct ctaggctgcg cgaaggaaga gggtacgacg    240

ccggggaggg actgggtgcg cgggcatgaa gttggaggtg ttcgtccctc gcgcggccca    300

cggggacaag cagggcagtg acctggaggg cgcgggcggc agcgacgcgc cgtccccgct    360

gtcggcggcg ggagacgact ccctgggctc agatggggac tgcgcggcca acagcccggc    420

cgcgggcggc ggcgccagag atacgcaggg cgacggcgaa cagagtgcgg gaggcgggcc    480

gggcgcggag gaggcgatcc cggcagcagc tgctgcagcg gtggtggcgg agggcgcgga    540

ggccggggcg gcggggccag gcgcgggcgg cgcggggagc ggcgagggtg cacgcagcaa    600

gccatatacg cggcggccca agccccccta ctcgtacatc gcgctcatcg ccatggccat    660

ccgcgactcg gcgggcgggc gcttgacgct ggcggagatc aacgagtacc tcatgggcaa    720

gttccccttt ttccgcggca gctacacggg ctggcgcaac tccgtgcgcc acaacctttc    780

gctcaacgac tgcttcgtca aggtgctgcg cgacccctcg cggccctggg gcaaggacaa    840

ctactggatg ctcaacccca acagcgagta caccttcgcc gacggggtct tccgccgccg    900

ccgcaagcgc ctcagccacc gcgcgccggt ccccgcgccc gggctgcggc ccgaggaggc    960

cccgggcctc cccgccgccc cgccgcccgc gcccgccgcc ccggcctcgc cccgcatgcg   1020

ctcgcccgcc cgccaggagg agcgcgccag ccccgcgggc aagttctcca gctccttcgc   1080

catcgacagc atcctgcgca agcccttccg cagccgccgc ctcagggaca cggcccccgg   1140

gacgacgctt cagtggggcg ccgcgccctg cccgccgctg cccgcgttcc ccgcgctcct   1200

ccccgcggcg ccctgcaggg ccctgctgcc gctctgcgcg tacggcgcgg gcgagccggc   1260

gcggctgggc gcgcgcgagg ccgaggtgcc accgaccgcg ccgcccctcc tgcttgcacc   1320

tctcccggcg gcggcccccg ccaagccact ccgaggcccg gcggccggcg gcgcgcacct   1380

gtactgcccc ctgcggctgc ccgcagccct gcaggcggcc tcagtccgcc gccctggccc   1440

gcacctgccg tacccggtgg agacgctcct agcctgagta gcgccgcggg gcccgggaac   1500

gccgagtgcg cgccgtcggg gaggcgggaa cgcgggcccg cgcgcggact ttgcactttg   1560

aatccagagg aagatgaatt tttaaaatct ccatcaaacg tgccttaaag ctaaagcatt   1620

ttgacaggag tatttaaact tagtccagga tattttcctt tgtgttttat aactttacag   1680

aggaccaaag caattcttgt tttagtttct ttgcgaagcc tgctcctcct tcccttcata   1740

aggacttttt ttgtctttct ttaacgccca ggcttcgtct tatttctact gtttttgtcg   1800

caacttccat tgatttatgt cccttccctc ccccctaagt acatcaggga acctttccac   1860

actataaatg atatgactac tgtttggggt ttctgggccc ccatccgtgt acgtatgtgg   1920

catttccagg tatgactgag tgtgagagac atgtcagagg ctcttcagtg atttcttgct   1980

attgaccgat gcttcactgt gccaaaagag aaaaaaaatg ttgggttttg taattaaatt   2040

atttatatat ttttgaaacc cgaattgaaa atgttgcagg caacgggcta cagctttatt   2100

agtggttctc taactgtggt ctccttgggc caagcaattt ctttaaagga aaagttgatt   2160

atgtatgtgg ggtgccagga ccactgcctt gaaagcaagt gtgattttta tttttaatat   2220

tattttattt gtgtctgtgt acatattcat gtataaattt tatgaaaccc aagcatagtg   2280

cttatttttt aataaaacaa ctgacttaac acattgtgaa aaaaaaaaaa aaaaaaaa     2338


<210>  316
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  316

Met Lys Leu Glu Val Phe Val Pro Arg Ala Ala His Gly Asp Lys Gln 
1               5                   10                  15


Gly Ser Asp Leu Glu Gly Ala Gly Gly Ser Asp Ala Pro Ser Pro Leu 
            20                  25                  30


Ser Ala Ala Gly Asp Asp Ser Leu Gly Ser Asp Gly Asp Cys Ala Ala 
        35                  40                  45


Asn Ser Pro Ala Ala Gly Gly Gly Ala Arg Asp Thr Gln Gly Asp Gly 
    50                  55                  60


Glu Gln Ser Ala Gly Gly Gly Pro Gly Ala Glu Glu Ala Ile Pro Ala 
65                  70                  75                  80


Ala Ala Ala Ala Ala Val Val Ala Glu Gly Ala Glu Ala Gly Ala Ala 
                85                  90                  95


Gly Pro Gly Ala Gly Gly Ala Gly Ser Gly Glu Gly Ala Arg Ser Lys 
            100                 105                 110


Pro Tyr Thr Arg Arg Pro Lys Pro Pro Tyr Ser Tyr Ile Ala Leu Ile 
        115                 120                 125


Ala Met Ala Ile Arg Asp Ser Ala Gly Gly Arg Leu Thr Leu Ala Glu 
    130                 135                 140


Ile Asn Glu Tyr Leu Met Gly Lys Phe Pro Phe Phe Arg Gly Ser Tyr 
145                 150                 155                 160


Thr Gly Trp Arg Asn Ser Val Arg His Asn Leu Ser Leu Asn Asp Cys 
                165                 170                 175


Phe Val Lys Val Leu Arg Asp Pro Ser Arg Pro Trp Gly Lys Asp Asn 
            180                 185                 190


Tyr Trp Met Leu Asn Pro Asn Ser Glu Tyr Thr Phe Ala Asp Gly Val 
        195                 200                 205


Phe Arg Arg Arg Arg Lys Arg Leu Ser His Arg Ala Pro Val Pro Ala 
    210                 215                 220


Pro Gly Leu Arg Pro Glu Glu Ala Pro Gly Leu Pro Ala Ala Pro Pro 
225                 230                 235                 240


Pro Ala Pro Ala Ala Pro Ala Ser Pro Arg Met Arg Ser Pro Ala Arg 
                245                 250                 255


Gln Glu Glu Arg Ala Ser Pro Ala Gly Lys Phe Ser Ser Ser Phe Ala 
            260                 265                 270


Ile Asp Ser Ile Leu Arg Lys Pro Phe Arg Ser Arg Arg Leu Arg Asp 
        275                 280                 285


Thr Ala Pro Gly Thr Thr Leu Gln Trp Gly Ala Ala Pro Cys Pro Pro 
    290                 295                 300


Leu Pro Ala Phe Pro Ala Leu Leu Pro Ala Ala Pro Cys Arg Ala Leu 
305                 310                 315                 320


Leu Pro Leu Cys Ala Tyr Gly Ala Gly Glu Pro Ala Arg Leu Gly Ala 
                325                 330                 335


Arg Glu Ala Glu Val Pro Pro Thr Ala Pro Pro Leu Leu Leu Ala Pro 
            340                 345                 350


Leu Pro Ala Ala Ala Pro Ala Lys Pro Leu Arg Gly Pro Ala Ala Gly 
        355                 360                 365


Gly Ala His Leu Tyr Cys Pro Leu Arg Leu Pro Ala Ala Leu Gln Ala 
    370                 375                 380


Ala Ser Val Arg Arg Pro Gly Pro His Leu Pro Tyr Pro Val Glu Thr 
385                 390                 395                 400


Leu Leu Ala 



<210>  317
<211>  2068
<212>  DNA
<213>  Homo sapiens

<400>  317
gacgccacgc aggctgccgt cacccttccg ggtgacatac cggccttggg gtacgcgtgc     60

cttcggggcc tttcctgtgt ttgggaccca gatctcctct cctccagaaa accttgacac    120

tgcccatctt cctcatccag aaggagcgtt cgaggaatgg atgaggtcgg ggtggaagaa    180

acgggtgatt cccttttttt gaaagagcgg aaaccggccg ggcggtttcc agggaggagc    240

atctgttcct cctcgcccgt ttttcgccct cgggctggcg agaactccct caggtcccaa    300

tccgtggact cgcaggggcc atgattgatt ccggagcgca gttaatcaag gcataatggc    360

atggacttga cacagcaagc aaaagacata cagaacataa cagtccagga aaccaacaaa    420

aataactctg aaagcattga atgcagcaaa ataacaatgg atctcaagtt caacaattcc    480

aggaaatata tttctatcac tgtgccatcc aaaacccaaa caatgtcacc acacatcaag    540

tcagttgacg acgttgtggt acttggcatg aatctcagca agtttaacaa acttactcag    600

tttttcatat gtgttgctgg agtttttgta ttttacctaa tttatgggta tttacaggaa    660

ttaatatttt cagtggaggg ttttaagtcc tgtggctggt accttacctt agtgcagttt    720

gccttttact ccatatttgg cctaatagaa cttcagctta ttcaggacaa aaggaggaga    780

ataccaggaa aaacctacat gataatagct tttctaactg tgggtactat ggggttatca    840

aacacttcct tgggctacct gaattaccct acccaagtca tcttcaagtg ctgcaaattg    900

attcctgtta tgctaggagg agtttttatt caaggaaagc gttataatgt tgcagatgtg    960

tctgctgcca tatgtatgag ccttggcctg atatggttta ccctcgctga cagcacaact   1020

gcaccaaatt tcaacctgac gggtgtggtg cttatttccc tggcactatg tgcagatgcc   1080

gtcattggaa atgttcaaga gaaagctatg aaacttcata atgcttctaa ttctgaaatg   1140

gtattgtatt cgtattcaat tggttttgta tacattttac tgggattgac atgcactagt   1200

ggattaggcc ctgcagtaac attttgtgca aagaatccag ttcggaccta tggttatgcg   1260

ttcctttttt ccctcactgg atattttgga atctcctttg ttctggcttt gattaaaatt   1320

tttggtgcac ttattgctgt aacagtgaca acaggaagaa aagcaatgac cattgtactt   1380

tcgtttatat tctttgctaa accattcacg tttcagtatg tatggtctgg tttgttagtt   1440

gtccttggta tatttctcaa tgtttacagc aaaaatatgg ataaaataag actaccatca   1500

ctgtatgatt tgataaacaa atcagtggaa gcaagaaagt caaggacgct ggcacagact   1560

gtatagacag tgattgtcct atttaaaata gaattttaag ggaacaatca tcaattaatt   1620

aactttccaa agggactgat aaaaaccaaa ggatctggag gcattgctat cccatttgtg   1680

ggcagatttc atatgaagtt gttttgcggt gtcagccttt tcttcagagc atttgtttga   1740

ctgacttcca aagcaatcaa gagagccacg tctagcagac tttacaataa aatgtcaata   1800

tgaaggactg taattcctag cagtttattg agaatttcac tggaaatgga ccatgtgttg   1860

caagactaat tggctataat tatatcctat caaagaaatc gatacgtaat agcagattgt   1920

tttatattca ttccattttg atggtgttat ttaaattgat tctctgttat aagagtaaac   1980

tgatgagttg aagtctggag agaataacat tcattataaa taaaattatt ctgtgatctt   2040

taaaaaaaaa aaaaaaaaaa aaaaaaaa                                      2068


<210>  318
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  318

Met Asp Leu Thr Gln Gln Ala Lys Asp Ile Gln Asn Ile Thr Val Gln 
1               5                   10                  15


Glu Thr Asn Lys Asn Asn Ser Glu Ser Ile Glu Cys Ser Lys Ile Thr 
            20                  25                  30


Met Asp Leu Lys Phe Asn Asn Ser Arg Lys Tyr Ile Ser Ile Thr Val 
        35                  40                  45


Pro Ser Lys Thr Gln Thr Met Ser Pro His Ile Lys Ser Val Asp Asp 
    50                  55                  60


Val Val Val Leu Gly Met Asn Leu Ser Lys Phe Asn Lys Leu Thr Gln 
65                  70                  75                  80


Phe Phe Ile Cys Val Ala Gly Val Phe Val Phe Tyr Leu Ile Tyr Gly 
                85                  90                  95


Tyr Leu Gln Glu Leu Ile Phe Ser Val Glu Gly Phe Lys Ser Cys Gly 
            100                 105                 110


Trp Tyr Leu Thr Leu Val Gln Phe Ala Phe Tyr Ser Ile Phe Gly Leu 
        115                 120                 125


Ile Glu Leu Gln Leu Ile Gln Asp Lys Arg Arg Arg Ile Pro Gly Lys 
    130                 135                 140


Thr Tyr Met Ile Ile Ala Phe Leu Thr Val Gly Thr Met Gly Leu Ser 
145                 150                 155                 160


Asn Thr Ser Leu Gly Tyr Leu Asn Tyr Pro Thr Gln Val Ile Phe Lys 
                165                 170                 175


Cys Cys Lys Leu Ile Pro Val Met Leu Gly Gly Val Phe Ile Gln Gly 
            180                 185                 190


Lys Arg Tyr Asn Val Ala Asp Val Ser Ala Ala Ile Cys Met Ser Leu 
        195                 200                 205


Gly Leu Ile Trp Phe Thr Leu Ala Asp Ser Thr Thr Ala Pro Asn Phe 
    210                 215                 220


Asn Leu Thr Gly Val Val Leu Ile Ser Leu Ala Leu Cys Ala Asp Ala 
225                 230                 235                 240


Val Ile Gly Asn Val Gln Glu Lys Ala Met Lys Leu His Asn Ala Ser 
                245                 250                 255


Asn Ser Glu Met Val Leu Tyr Ser Tyr Ser Ile Gly Phe Val Tyr Ile 
            260                 265                 270


Leu Leu Gly Leu Thr Cys Thr Ser Gly Leu Gly Pro Ala Val Thr Phe 
        275                 280                 285


Cys Ala Lys Asn Pro Val Arg Thr Tyr Gly Tyr Ala Phe Leu Phe Ser 
    290                 295                 300


Leu Thr Gly Tyr Phe Gly Ile Ser Phe Val Leu Ala Leu Ile Lys Ile 
305                 310                 315                 320


Phe Gly Ala Leu Ile Ala Val Thr Val Thr Thr Gly Arg Lys Ala Met 
                325                 330                 335


Thr Ile Val Leu Ser Phe Ile Phe Phe Ala Lys Pro Phe Thr Phe Gln 
            340                 345                 350


Tyr Val Trp Ser Gly Leu Leu Val Val Leu Gly Ile Phe Leu Asn Val 
        355                 360                 365


Tyr Ser Lys Asn Met Asp Lys Ile Arg Leu Pro Ser Leu Tyr Asp Leu 
    370                 375                 380


Ile Asn Lys Ser Val Glu Ala Arg Lys Ser Arg Thr Leu Ala Gln Thr 
385                 390                 395                 400


Val 



<210>  319
<211>  3132
<212>  DNA
<213>  Homo sapiens

<400>  319
gaagcagagg aggaaggaga gaagaggtgg aggtggccgc aggctgagtc gcggccggga     60

tgtccgggca gccgccgccg ccgccgccgc agcagcagca acagcagcag cagctgtcgc    120

cgccaccgcc ggcggccttg gccccagtct ccggagtcgt cctgccggcg cccccggccg    180

tcagcgccgg ctcttctccg gccggctcgc ccggcggcgg tgcgggcggc gaaggcttag    240

gggccgcggc ggccgccctg ctcctccacc ctccgccgcc gccgcccccg gccaccgcgg    300

ccccgccgcc cccgccgccg cccccgcctc cccctgcctc agcggctgcc cccgccagcg    360

ggccgcccgc tcccccgggc cttgcagcgg gccccggccc ggctggagga gccccgaccc    420

cagctctggt ggcgggcagc agcgccgcgg cccccttccc tcacggggac tcggccctga    480

acgagcagga gaaggagttg cagcggcggc tgaagcgtct ctacccggcc gtggacgaac    540

aagagacgcc gctgcctcgg tcctggagcc cgaaggacaa gttcagctac atcggcctct    600

ctcagaacaa cctgcgggtg cactacaaag gtcatggcaa aaccccaaaa gatgccgcgt    660

cagttcgagc cacgcatcca ataccagcag cctgtgggat ttattatttt gaagtaaaaa    720

ttgtcagtaa gggaagagat ggttacatgg gaattggtct ttctgctcaa ggtgtgaaca    780

tgaatagact accaggttgg gataagcatt catatggtta ccatggggat gatggacatt    840

cgttttgttc ttctggaact ggacaacctt atggaccaac tttcactact ggtgatgtca    900

ttggctgttg tgttaatctt atcaacaata cctgctttta caccaagaat ggacatagtt    960

taggtattgc tttcactgac ctaccgccaa atttgtatcc tactgtgggg cttcaaacac   1020

caggagaagt ggtcgatgcc aattttgggc aacatccttt cgtgtttgat atagaagact   1080

atatgcggga gtggagaacc aaaatccagg cacagataga tcgatttcct atcggagatc   1140

gagaaggaga atggcagacc atgatacaaa aaatggtttc atcttattta gtccaccatg   1200

ggtactgtgc cacagcagag gcctttgcca gatctacaga ccagaccgtt ctagaagaat   1260

tagcttccat taagaataga caaagaattc agaaattggt attagcagga agaatgggag   1320

aagccattga aacaacacaa cagttatacc caagtttact tgaaagaaat cctaatctcc   1380

ttttcacatt aaaagtgcgt cagtttatag aaatggtgaa tggtacagat agtgaagtac   1440

gatgtttggg aggccgaagt ccaaagtctc aagacagtta tcctgttagt cctcgacctt   1500

ttagtagtcc aagtatgagc cccagccatg gaatgaatat ccacaattta gcatcaggca   1560

aaggaagcac cgcacatttt tcaggttttg aaagttgtag taatggtgta atatcaaata   1620

aagcacatca atcatattgc catagtaata aacaccagtc atccaacttg aatgtaccag   1680

aactaaacag tataaatatg tcaagatcac agcaagttaa taacttcacc agtaatgatg   1740

tagacatgga aacagatcac tactccaatg gagttggaga aacttcatcc aatggtttcc   1800

taaatggtag ctctaaacat gaccacgaaa tggaagattg tgacaccgaa atggaagttg   1860

attcaagtca gttgagacgc cagttgtgtg gaggaagtca ggccgccata gaaagaatga   1920

tccactttgg acgagagctg caagcaatga gtgaacagct aaggagagac tgtggcaaga   1980

acactgcaaa caaaaaaatg ttgaaggatg cattcagtct actagcatat tcagatccct   2040

ggaacagccc agttggaaat cagcttgacc cgattcagag agaacctgtg tgctcagctc   2100

ttaacagtgc aatattagaa acccacaatc tgccaaagca acctccactt gccctagcaa   2160

tgggacaggc cacacaatgt ctaggactga tggctcgatc aggaattgga tcctgcgcat   2220

ttgccacagt ggaagactac ctacattagc tatgcatttc aagagctcac acttatattg   2280

tggcatatag tcaacatgga agtagaccag ctctgctgat ttgaaattta gattttttaa   2340

attatgtact ggggacaggt ttttgtcgct ttacattgct tcctagttta cagcatgatg   2400

caaatgattt tctaacttag tgttaggaga aattattttc catctttaac ctcttagttg   2460

tctaagagtt aaatattact gaatttcaga cgttcaaatt gatcatcaca aatcctttaa   2520

aacaattacc taaaagaaac caaaaatcct gccttctttg tgggggaggg gggagagagg   2580

ggaaggaaat ggaacaagtt gtgtttgtgt tagcatgtgg gtgatgtaaa cttcaaattg   2640

ggagatgttc cgacccccac tcccatataa gcattcaatc agtgtaactt gcaaaatgca   2700

taaacatccg acagtttgaa tttatagtgt tgatggaaga aatcattttt aatgtgtact   2760

gtaaaacttg aaatactcag gagctgagtg aatatgtttg ttgctactta caatcccgac   2820

ctgttagtcc cagtagtttt gttttaacat ggtctttttc aactttgttt cctgtttaac   2880

tacagatgac ttctgttgta gactcacaag tttaactgtt gtattataac agtattacat   2940

gtcaacggtg tggttatgac ctttatttat ataaaaacca aatatttagt caatttaccg   3000

tgtcttaatt taatctttgt acaccttcca tttttaagtg cttaaatgag tactatattg   3060

caataaaatg tagtgatata attaaccagc cattaaaaat ttacttctac agaaaaaaaa   3120

aaaaaaaaaa aa                                                       3132


<210>  320
<211>  729
<212>  PRT
<213>  Homo sapiens

<400>  320

Met Ser Gly Gln Pro Pro Pro Pro Pro Pro Gln Gln Gln Gln Gln Gln 
1               5                   10                  15


Gln Gln Leu Ser Pro Pro Pro Pro Ala Ala Leu Ala Pro Val Ser Gly 
            20                  25                  30


Val Val Leu Pro Ala Pro Pro Ala Val Ser Ala Gly Ser Ser Pro Ala 
        35                  40                  45


Gly Ser Pro Gly Gly Gly Ala Gly Gly Glu Gly Leu Gly Ala Ala Ala 
    50                  55                  60


Ala Ala Leu Leu Leu His Pro Pro Pro Pro Pro Pro Pro Ala Thr Ala 
65                  70                  75                  80


Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Ser Ala Ala 
                85                  90                  95


Ala Pro Ala Ser Gly Pro Pro Ala Pro Pro Gly Leu Ala Ala Gly Pro 
            100                 105                 110


Gly Pro Ala Gly Gly Ala Pro Thr Pro Ala Leu Val Ala Gly Ser Ser 
        115                 120                 125


Ala Ala Ala Pro Phe Pro His Gly Asp Ser Ala Leu Asn Glu Gln Glu 
    130                 135                 140


Lys Glu Leu Gln Arg Arg Leu Lys Arg Leu Tyr Pro Ala Val Asp Glu 
145                 150                 155                 160


Gln Glu Thr Pro Leu Pro Arg Ser Trp Ser Pro Lys Asp Lys Phe Ser 
                165                 170                 175


Tyr Ile Gly Leu Ser Gln Asn Asn Leu Arg Val His Tyr Lys Gly His 
            180                 185                 190


Gly Lys Thr Pro Lys Asp Ala Ala Ser Val Arg Ala Thr His Pro Ile 
        195                 200                 205


Pro Ala Ala Cys Gly Ile Tyr Tyr Phe Glu Val Lys Ile Val Ser Lys 
    210                 215                 220


Gly Arg Asp Gly Tyr Met Gly Ile Gly Leu Ser Ala Gln Gly Val Asn 
225                 230                 235                 240


Met Asn Arg Leu Pro Gly Trp Asp Lys His Ser Tyr Gly Tyr His Gly 
                245                 250                 255


Asp Asp Gly His Ser Phe Cys Ser Ser Gly Thr Gly Gln Pro Tyr Gly 
            260                 265                 270


Pro Thr Phe Thr Thr Gly Asp Val Ile Gly Cys Cys Val Asn Leu Ile 
        275                 280                 285


Asn Asn Thr Cys Phe Tyr Thr Lys Asn Gly His Ser Leu Gly Ile Ala 
    290                 295                 300


Phe Thr Asp Leu Pro Pro Asn Leu Tyr Pro Thr Val Gly Leu Gln Thr 
305                 310                 315                 320


Pro Gly Glu Val Val Asp Ala Asn Phe Gly Gln His Pro Phe Val Phe 
                325                 330                 335


Asp Ile Glu Asp Tyr Met Arg Glu Trp Arg Thr Lys Ile Gln Ala Gln 
            340                 345                 350


Ile Asp Arg Phe Pro Ile Gly Asp Arg Glu Gly Glu Trp Gln Thr Met 
        355                 360                 365


Ile Gln Lys Met Val Ser Ser Tyr Leu Val His His Gly Tyr Cys Ala 
    370                 375                 380


Thr Ala Glu Ala Phe Ala Arg Ser Thr Asp Gln Thr Val Leu Glu Glu 
385                 390                 395                 400


Leu Ala Ser Ile Lys Asn Arg Gln Arg Ile Gln Lys Leu Val Leu Ala 
                405                 410                 415


Gly Arg Met Gly Glu Ala Ile Glu Thr Thr Gln Gln Leu Tyr Pro Ser 
            420                 425                 430


Leu Leu Glu Arg Asn Pro Asn Leu Leu Phe Thr Leu Lys Val Arg Gln 
        435                 440                 445


Phe Ile Glu Met Val Asn Gly Thr Asp Ser Glu Val Arg Cys Leu Gly 
    450                 455                 460


Gly Arg Ser Pro Lys Ser Gln Asp Ser Tyr Pro Val Ser Pro Arg Pro 
465                 470                 475                 480


Phe Ser Ser Pro Ser Met Ser Pro Ser His Gly Met Asn Ile His Asn 
                485                 490                 495


Leu Ala Ser Gly Lys Gly Ser Thr Ala His Phe Ser Gly Phe Glu Ser 
            500                 505                 510


Cys Ser Asn Gly Val Ile Ser Asn Lys Ala His Gln Ser Tyr Cys His 
        515                 520                 525


Ser Asn Lys His Gln Ser Ser Asn Leu Asn Val Pro Glu Leu Asn Ser 
    530                 535                 540


Ile Asn Met Ser Arg Ser Gln Gln Val Asn Asn Phe Thr Ser Asn Asp 
545                 550                 555                 560


Val Asp Met Glu Thr Asp His Tyr Ser Asn Gly Val Gly Glu Thr Ser 
                565                 570                 575


Ser Asn Gly Phe Leu Asn Gly Ser Ser Lys His Asp His Glu Met Glu 
            580                 585                 590


Asp Cys Asp Thr Glu Met Glu Val Asp Ser Ser Gln Leu Arg Arg Gln 
        595                 600                 605


Leu Cys Gly Gly Ser Gln Ala Ala Ile Glu Arg Met Ile His Phe Gly 
    610                 615                 620


Arg Glu Leu Gln Ala Met Ser Glu Gln Leu Arg Arg Asp Cys Gly Lys 
625                 630                 635                 640


Asn Thr Ala Asn Lys Lys Met Leu Lys Asp Ala Phe Ser Leu Leu Ala 
                645                 650                 655


Tyr Ser Asp Pro Trp Asn Ser Pro Val Gly Asn Gln Leu Asp Pro Ile 
            660                 665                 670


Gln Arg Glu Pro Val Cys Ser Ala Leu Asn Ser Ala Ile Leu Glu Thr 
        675                 680                 685


His Asn Leu Pro Lys Gln Pro Pro Leu Ala Leu Ala Met Gly Gln Ala 
    690                 695                 700


Thr Gln Cys Leu Gly Leu Met Ala Arg Ser Gly Ile Gly Ser Cys Ala 
705                 710                 715                 720


Phe Ala Thr Val Glu Asp Tyr Leu His 
                725


<210>  321
<211>  1248
<212>  DNA
<213>  Homo sapiens

<400>  321
aggaaagggc ggtcctgcgc tgtggcccac gctcgctccc gctgtcggac tctgggcctg     60

gaccgcgcgt ggccggcgcc aaaagcgaga ggcatgagcg cgcgcccggg ccagtgaact    120

gctcggggat ggactgcggc tcggtcggcg gccagaggac ccagcgcctg cccggccgcc    180

agcggcttct cttcttgccc gtgggcctca gcggaagacc gggcggcagc gaaacctcag    240

cacgccgctg cctctctgcg ctctccgacg gtctgggggc gctgcgccct cgcgccccgg    300

cggcccgcgg cggcgtgtca cgtgcctcac cgctgctcct cctcctgcta gtgccctccc    360

cgcgcttggc cgccgcagcc ccgcgccggc agctcgggga ctgggagcgc tcgcgcctcg    420

ggtatgccgc acccccggcc gggcgcagca gcgcgtggag gtgctcaccg ggcgtcgccg    480

ctgccgccgg cgcccttccc cagtaccacg gcccggcgcc tgcactcgtt tcctgcagga    540

gagagctaag cttgtctgct ggatccctgc agctggagcg caaaaggaga gatttcacct    600

cttctgggag caggaaactc tacttcgaca ctcatgcctt agtgtgctta ctggaagaca    660

atgggtttgc tactcaacaa gcagaaatca ttgtgtctgc attggtcaag atcctggagg    720

ccaacatgga catcgtctac aaagatatgg tcaccaagat gcagcaggaa atcacttttc    780

agcaagtaat gtctcagatt gcgaatgtga aaaaggatat gattattttg gagaagagtg    840

aattttcagc cctcagagca gaaaatgaga aaataaaact cgaactacat cagttaaaac    900

aacaagtaat ggatgaagtg atcaaagtcc gaacagatac caaattagac ttcaacctag    960

aaaagagcag agtaaaagaa ttgtattcat tgaacgaaaa gaagctgctg gaattgagaa   1020

cagaaatagt ggcattgcat gcccagcaag atcgggccct tacccagaca gacaggaaga   1080

tcgaaactga ggttgctggc ctcaaaacca tgcttgagtc acacaagctt gataatatta   1140

aatatttagc agggtctata tttacgtgcc taacagtagc tctgggattt tatcgcctgt   1200

ggatctaata aagtgtctat ttaaagtgaa aaaaaaaaaa aaaaaaaa                1248


<210>  322
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  322

Met Asp Cys Gly Ser Val Gly Gly Gln Arg Thr Gln Arg Leu Pro Gly 
1               5                   10                  15


Arg Gln Arg Leu Leu Phe Leu Pro Val Gly Leu Ser Gly Arg Pro Gly 
            20                  25                  30


Gly Ser Glu Thr Ser Ala Arg Arg Cys Leu Ser Ala Leu Ser Asp Gly 
        35                  40                  45


Leu Gly Ala Leu Arg Pro Arg Ala Pro Ala Ala Arg Gly Gly Val Ser 
    50                  55                  60


Arg Ala Ser Pro Leu Leu Leu Leu Leu Leu Val Pro Ser Pro Arg Leu 
65                  70                  75                  80


Ala Ala Ala Ala Pro Arg Arg Gln Leu Gly Asp Trp Glu Arg Ser Arg 
                85                  90                  95


Leu Gly Tyr Ala Ala Pro Pro Ala Gly Arg Ser Ser Ala Trp Arg Cys 
            100                 105                 110


Ser Pro Gly Val Ala Ala Ala Ala Gly Ala Leu Pro Gln Tyr His Gly 
        115                 120                 125


Pro Ala Pro Ala Leu Val Ser Cys Arg Arg Glu Leu Ser Leu Ser Ala 
    130                 135                 140


Gly Ser Leu Gln Leu Glu Arg Lys Arg Arg Asp Phe Thr Ser Ser Gly 
145                 150                 155                 160


Ser Arg Lys Leu Tyr Phe Asp Thr His Ala Leu Val Cys Leu Leu Glu 
                165                 170                 175


Asp Asn Gly Phe Ala Thr Gln Gln Ala Glu Ile Ile Val Ser Ala Leu 
            180                 185                 190


Val Lys Ile Leu Glu Ala Asn Met Asp Ile Val Tyr Lys Asp Met Val 
        195                 200                 205


Thr Lys Met Gln Gln Glu Ile Thr Phe Gln Gln Val Met Ser Gln Ile 
    210                 215                 220


Ala Asn Val Lys Lys Asp Met Ile Ile Leu Glu Lys Ser Glu Phe Ser 
225                 230                 235                 240


Ala Leu Arg Ala Glu Asn Glu Lys Ile Lys Leu Glu Leu His Gln Leu 
                245                 250                 255


Lys Gln Gln Val Met Asp Glu Val Ile Lys Val Arg Thr Asp Thr Lys 
            260                 265                 270


Leu Asp Phe Asn Leu Glu Lys Ser Arg Val Lys Glu Leu Tyr Ser Leu 
        275                 280                 285


Asn Glu Lys Lys Leu Leu Glu Leu Arg Thr Glu Ile Val Ala Leu His 
    290                 295                 300


Ala Gln Gln Asp Arg Ala Leu Thr Gln Thr Asp Arg Lys Ile Glu Thr 
305                 310                 315                 320


Glu Val Ala Gly Leu Lys Thr Met Leu Glu Ser His Lys Leu Asp Asn 
                325                 330                 335


Ile Lys Tyr Leu Ala Gly Ser Ile Phe Thr Cys Leu Thr Val Ala Leu 
            340                 345                 350


Gly Phe Tyr Arg Leu Trp Ile 
        355


<210>  323
<211>  10692
<212>  DNA
<213>  Homo sapiens

<400>  323
gaggagagag cagagtatac cgcagacatc atttctacta cagtggcgga gccgtacagg     60

acctgtttca ctgcaggggg atccaaaaca agccccgtgg agcagcagcc agagcaacag    120

cagccgcaag acattgtttc tctccctctg cccccccttc cccacgcaac cccagatcca    180

tttacacttt acagttttac ctcacaaaaa ctactacaag caccaagctc cctgatggaa    240

aggagcatcg tgcatcaagt caccagggtg gtccattcaa gctgcagatt tgtttgtcat    300

ccttgtacag caatctcctc ctccactgcc actacaggga agtgcatcac atgtcagcat    360

actggagcat agtgaaagag tctattttga agcttcaaac ttagtgctgc tgcagaccag    420

gaacaagaga gaaagagtgg atttcagcct gcacggatgg tcttgaaaca caaatggttt    480

ttggtctagg cgttttacac tgagattctc cactgccacc ctttctactc aagcaaaatc    540

ttcgtgaaaa gatctgctgc aaggaactga tagcttatgg ttctccattg tgatgaaagc    600

acatggtaca gttttccaaa gaaattagac cattttcttc gtgagaaaga aatcgacgtg    660

ctgttttcat agggtatttc tcacttctct gtgaaaggaa gaaagaacac gcctgagccc    720

aagagccctc aggagccctc cagagcctgt gggaagtctc catggtgaag tataggctga    780

ggctacctgt gaacagtacg cagtgaatgt tcatccagag ctgctgttgg cggattgtac    840

ccacggggag atgattcctc atgaagagcc tggatcccct acagaaatca aatgtgactt    900

tccgtttatc agactaaaat cagagccatc cagacagtga aacagtcacc gtggaggggg    960

gacggcgaaa aatgaaatcc aaccaagagc ggagcaacga atgcctgcct cccaagaagc   1020

gcgagatccc cgccaccagc cggtcctccg aggagaaggc ccctaccctg cccagcgaca   1080

accaccgggt ggagggcaca gcatggctcc cgggcaaccc tggtggccgg ggccacgggg   1140

gcgggaggca tgggccggca gggacctcgg tggagcttgg tttacaacag ggaataggtt   1200

tacacaaagc attgtccaca gggctggact actccccgcc cagcgctccc aggtctgtcc   1260

ccgtggccac cacgctgcct gccgcgtacg ccaccccgca gccagggacc ccggtgtccc   1320

ccgtgcagta cgctcacctg ccgcacacct tccagttcat tgggtcctcc caatacagtg   1380

gaacctatgc cagcttcatc ccatcacagc tgatcccccc aaccgccaac cccgtcacca   1440

gtgcagtggc ctcggccgca ggggccacca ctccatccca gcgctcccag ctggaggcct   1500

attccactct gctggccaac atgggcagtc tgagccagac gccgggacac aaggctgagc   1560

agcagcagca gcagcagcag cagcagcagc agcagcatca gcatcagcag cagcagcagc   1620

agcagcagca gcagcagcag cagcagcacc tcagcagggc tccggggctc atcaccccgg   1680

ggtccccccc accagcccag cagaaccagt acgtccacat ttccagttct ccgcagaaca   1740

ccggccgcac cgcctctcct ccggccatcc ccgtccacct ccacccccac cagacgatga   1800

tcccacacac gctcaccctg gggcccccct cccaggtcgt catgcaatac gccgactccg   1860

gcagccactt tgtccctcgg gaggccacca agaaagctga gagcagccgg ctgcagcagg   1920

ccatccaggc caaggaggtc ctgaacggtg agatggagaa gagccggcgg tacggggccc   1980

cgtcctcagc cgacctgggc ctgggcaagg caggcggcaa gtcggttcct cacccgtacg   2040

agtccaggca cgtggtggtc cacccgagcc cctcagacta cagcagtcgt gatccttcgg   2100

gggtccgggc ctctgtgatg gtcctgccca acagcaacac gcccgcagct gacctggagg   2160

tgcaacaggc cactcatcgt gaagcctccc cttctaccct caacgacaaa agtggcctgc   2220

atttagggaa gcctggccac cggtcctacg cgctctcacc ccacacggtc attcagacca   2280

cacacagtgc ttcagagcca ctcccggtgg gactgccagc cacggccttc tacgcaggga   2340

ctcaaccccc tgtcatcggc tacctgagcg gccagcagca agcaatcacc tacgccggca   2400

gcctgcccca gcacctggtg atccccggca cacagcccct gctcatcccg gtcggcagca   2460

ctgacatgga agcgtcgggg gcagccccgg ccatagtcac gtcatccccc cagtttgctg   2520

cagtgcctca cacgttcgtc accaccgccc ttcccaagag cgagaacttc aaccctgagg   2580

ccctggtcac ccaggccgcc tacccagcca tggtgcaggc ccagatccac ctgcctgtgg   2640

tgcagtccgt ggcctccccg gcggcggctc cccctacgct gcctccctac ttcatgaaag   2700

gctccatcat ccagttggcc aacggggagc taaagaaggt ggaagactta aaaacagaag   2760

atttcatcca gagtgcagag ataagcaacg acctgaagat cgactccagc accgtagaga   2820

ggattgaaga cagccatagc ccgggcgtgg ccgtgataca gttcgccgtc ggggagcacc   2880

gagcccaggt cagcgttgaa gttttggtag agtatccttt ttttgtgttt ggacagggct   2940

ggtcatcctg ctgtccggag agaaccagcc agctctttga tttgccgtgt tccaaactct   3000

cagttgggga tgtctgcatc tcgcttaccc tcaagaacct gaagaacggc tctgttaaaa   3060

agggccagcc cgtggatccc gccagcgtcc tgctgaagca ctcaaaggcc gacggcctgg   3120

cgggcagcag acacaggtat gccgagcagg aaaacggaat caaccagggg agtgcccaga   3180

tgctctctga gaatggcgaa ctgaagtttc cagagaaaat gggattgcct gcagcgccct   3240

tcctcaccaa aatagaaccc agcaagcccg cggcaacgag gaagaggagg tggtcggcgc   3300

cagagagccg caaactggag aagtcagaag acgaaccacc tttgactctt cctaagcctt   3360

ctctaattcc tcaggaggtt aagatttgca ttgaaggccg gtctaatgta ggcaagtaga   3420

ggcagcgtgg gggaaaggaa acgtggctct cccttatcat ttgtatccag attactgtac   3480

tgtaggctaa aataacacag tatttacatg ttatcttctt aattttaggt ttctgttcta   3540

accttgtcat tagagttaca gcaggtgtgt cgcaggagac tggtgcatat gctttttcca   3600

cgagtgtctg tcagtgagcg ggcgggagga agggcacagc aggagcggtc agggctccag   3660

gcatccccgg ggaagaaagg aacggggctt cacagtgcct gccttctcta gcggcacaga   3720

agcagccggg ggcgctgact cccgctagtg tcaggagaaa agtcccgtgg gaagagtcct   3780

gcaggggtgc agggttgcac gcatgtgggg gtgcacaggc gctgtggcgg cgagtgaggg   3840

tctctttttc tctgcctccc tctgcctcac tctcttgcta tcggcatggg ccgggggggt   3900

tcagagcagt gtcctcctgg ggttcccacg tgcaaaatca acatcaggaa cccagcttca   3960

gggcatcgcg gagacgcgtc agatggcaga tttggaaagt taaccattta aaagaacatt   4020

tttctctcca acatatttta caataaaagc aacttttaat tgtatagata tatatttccc   4080

cctatggggc ctgactgcac tgatatatat tttttttaaa gagcaactgc cacatgcggg   4140

atttcatttc tgctttttac tagtgcagcg atgtcaccag ggtgttgtgg tggacaggga   4200

agcccctgct gtcatggccc cacatggggt aaggggggtt gggggtgggg gagagggaga   4260

gagcgaacac ccacgctggt ttctgtgcag tgttaggaaa accaatcagg ttattgcatt   4320

gacttcactc ccaagaggta gatgcaaact gcccttcagt gagagcaaca gaagctcttc   4380

acgttgagtt tgcgaaatct ttttgtcttt gaactctagt actgtttata gttcatgact   4440

atggacaact cgggtgccac tttttttttt tttcagattc cagtgtgaca tgaggaatta   4500

gattttgaag atgagcatat attactatct ttaagcattt aaaaatactg ttcacacttt   4560

attaccaagc atcttggtct ctcattcaac aagtactgta tctcacttta aactctttgg   4620

ggaaaaaaca aaaacaaaaa aaactaagtt gctttctttt tttcaacact gtaactacat   4680

ttcagctctg cagaattgct gaagagcaag atattgaaag tttcaatgtg gtttaaaggg   4740

atgaatgtga attatgaact agtatgtgac aataaatgac caccaagtac tacctgacgg   4800

gaggcacttt tcactttgat gtctgagaat cagttcaagg catatgcaga gttggcagag   4860

aaactgagag aaaagggatg gagaagagaa tactcatttt tgtccagtgt ttttcttttt   4920

aagatgaact tttaaagaac cttgcgattt gcacatattg agtttataac ttgtgtgata   4980

ttcctgcagt ttttatccaa taacattgtg ggaaaggttt gggggactga acgagcataa   5040

ataaatgtag caaaatttct ttctaacctg cctaaactct aggccatttt ataaggttat   5100

gttcctttga aaattcattt tggtcttttt accacatctg tcacaaaaag ccaggtctta   5160

gcgggctctt agaaactctg agaattttct tcagattcat tgagagagtt ttccataaag   5220

acatttatat atgtgagcaa gatttttttt aaacaattac tttattattg ttgttattaa   5280

tgttattttc agaatggctt ttttttttct attcaaaatc aaatcgagat ttaatgtttg   5340

gtacaaaccc agaaagggta tttcatagtt tttaaacctt tcattcccag agatccgaaa   5400

tatcatttgt gggttttgaa tgcatcttta aagtgcttta aaaaaaagtt ttataagtag   5460

ggagaaattt ttaaatattc ttacttggat ggctgcaact aaactgaaca aatacctgac   5520

ttttctttta ccccattgaa aatagtactt tcttcgtttc acaaattaaa aaaaaaatct   5580

ggtatcaacc cacattttgg ctgtctagta ttcatttaca tttagggttc accaggacta   5640

atgattttta taaaccgttt tctggggtgt accaaaaaca tttgaatagg tttagaatag   5700

ctagaatagt tccttgactt tcctcgaatt tcattaccct ctcagcatgc ttgcagagag   5760

ctgggtgggc tcattcttgc agtcatactg cttatttagt gctgtatttt ttaaacgttt   5820

ctgttcagag aacttgctta atcttccata tattctgctc agggcacttg caattattag   5880

gttttgtttt tctttttgtt ttttagcctt tgatggtaag aggaatacgg gctgccacat   5940

agactttgtt ctcattaata tcactattta caactcatgt ggactcagaa aaacacacac   6000

caccttttgg cttacttcga gtattgaatt gactggatcc actaaaccaa cactaagatg   6060

ggaaaacaca catggtttgg agcaatagga acatcatcat aatttttgtg gttctatttc   6120

aggtatagga attataaaat aattggttct ttctaaacac ttgtcccatt tcattctctt   6180

gcttttttag catgtgcaat actttctgtg ccaatagagt ctgaccagtg tgctatatag   6240

ttaaagctca ttcccttttg gctttttcct tgtttggttg atcttcccca ttctggccag   6300

agcagggctg gagggaagga gccaggaggg agagagcctc ccacctttcc cctgctgcgg   6360

atgctgagtg ctggggcggg gagccttcag gagccccgtg cgtctgccgc cacgttgcag   6420

aaagagccag ccaaggagac ccgggggagg aaccgcagtg tcccctgtca ccacacggaa   6480

tagtgaatgt ggagtgtgga gaggaaggag gcagattcat ttctaagacg cactctggag   6540

ccatgtagcc tggagtcaac ccattttcca cggtcttttc tgcaagtggg caggcccctc   6600

ctcggggtct gtgtccttga gacttggagc cctgcctctg agcctggacg ggaagtgtgg   6660

cctgttgtgt gtgtgcgttc tgagcgtgtt ggccagtggc tgtggagggg accacctgcc   6720

acccacggtc accactccct tgtggcagct ttctcttcaa ataggaagaa cgcacagagg   6780

gcaggagcct cctgtttgca gacgttggcg ggccccgagg ctcccagagc agcctctgtc   6840

accgcttctg tgtagcaaac attaacgatg acaggggtag aaattcttcg gtgccgttca   6900

gcttacaagg atcagccatg tgcctctgta ctatgtccac tttgcaatat ttaccgacag   6960

ccgtcttttg ttctttcttt cctgttttcc atttttaaac tagtaacagc aggccttttg   7020

cgtttacaat ggaacacaat caccaagaaa ttagtcaggg cgaaaagaaa aaaataatac   7080

tattaataag aaaccaacaa acaagaacct ctctttctag ggatttctaa atatataaaa   7140

tgactgttcc ttagaatgtt taacttaaga attatttcag tttgtctggg ccacactggg   7200

gcagaggggg gagggaggga tacagagatg gatgccactt acctcagatc ttttaaagtg   7260

gaaatccaaa ttgaattttc atttggactt tcaggataat tttctatgtt ggtcaacttt   7320

tcgttttccc taactcaccc agtttagttt gggatgattt gatttctgtt gttgttgatc   7380

ccatttctaa cttggaattg tgagcctcta tgttttctgt taggtgagtg tgttgggttt   7440

tttcccccca ccaggaagtg gcagcatccc tccttctccc ctaaagggac tctgcggaac   7500

ctttcacacc tctttctcag ggacggggca ggtgtgtgtg tggtacactg acgtgtccag   7560

aagcagcact ttgactgctc tggagtaggg ttgtacaatt tcaaggaatg tttggatttc   7620

ctgcatcttg tggattactc cttagatacc gcatagattg caatataatg ctgcatgttc   7680

aagatgaaca gtagctccta gtaatcataa aatccactct ttgcacagtt tgatctttac   7740

tgaaatatgt tgccaaaatt tatttttgtt gttgtagctc tggattttgt tttgttttgt   7800

tttttaagga aacgattgac aatacccttt aacatctgtg actactaagg aaacctattt   7860

ctttcataga gagaaaaatc tccaatgctt ttgaagacac taataccgtg ctatttcaga   7920

tatgggtgag gaagcagagc tctcggtacc gaaggccggg cttcttgagc tgtgttggtt   7980

gtcatggcta ctgtttcatg aaccacaagc agctcaacag actggtctgt tgccttctga   8040

aaccctttgc acttcaattt gcaccaggtg aaaacagggc cagcagactc catggcccaa   8100

ttcggtttct tcggtggtga tgtgaaagga gagaattaca cttttttttt ttttaagtgg   8160

cgtggaggcc tttgcttcca catttgtttt taacccagaa tttctgaaat agagaattta   8220

agaacacatc aagtaataaa tatacagaga atatactttt ttataaagca catgcatctg   8280

ctattgtgtt gggttggttt cctctctttt ccacggacag tgttgtgttt ctggcatagg   8340

gaaactccaa acaacttgca cacctctact ccggagctga gatttctttt acatagatga   8400

cctcgcttca aatacgttac cttactgatg ataggatctt ttcttgtagc actatacctt   8460

gtgggaattt ttttttaaat gtacacctga tttgagaagc tgaagaaaac aaaattttga   8520

agcactcact ttgaggagta caggtaatgt tttaaaaaat tgcacaaaag aaaaatgaat   8580

gtcgaaatga ttcattcagt gtttgaaaga tatggctctg ttgaaacaat gagtttcata   8640

ctttgtttgt aaaaaaaaaa aagcagagaa gggttgaaag ttacatgttt ttttgtatat   8700

agaaatttgt catgtctaaa tgatcagatt tgtatggtta tggcctggaa gaattactac   8760

gtaaaaggct cttaaactat acctatgctt attgttattt ttgttacata tagccctcgt   8820

ctgagggagg ggaactcggt attctgcgat ttgagaatac tgttcattcc tatgctgaaa   8880

gtacttctct gagctccctt cttagtctaa actcttaagc cattgcaact tctttttctt   8940

cagagatgat gtttgacatt ttcagcactt cctgttccta taaacccaaa gaatataatc   9000

ttgaacacga agtgtttgta acaagggatc caggctacca atcaaacagg actcattatg   9060

gggacaaaaa aaaaaattat ttcaccttct ttccccccac acctcattta aatgggggga   9120

gtaaaaacat gatttcaatg taaatgcctc attttatttt agttttattt tgatttttat   9180

ttaatataaa gaggccagaa taaatacgga gcatcttctc agaatagtat tcctgtccaa   9240

aaatcaagcc ggacagtgga aactggacag ctgtggggat attaagcacc cccacttaca   9300

attcttaaat tcagaatctc gtcccctccc ttctcgttga aggcaactgt tctggtagct   9360

aactttctcc tgtgtaatgg cgggagggaa caccggcttc agtttttcat gtccccatga   9420

cttgcataca aatggttcaa ctgtattaaa attaagtgca tttggccaat aggtagtatc   9480

tatacaataa caacaatctc taagaatttc cataactttt cttatctgaa aggactcaag   9540

tcttccactg cagatacatt ggaggcttca cccacgtttt ctttcccttt agtttgtttg   9600

ctgtctggat ggccaatgag cctgtctcct tttctgtggc caatctgaag gccttcgttg   9660

gaagtgttgt ttacagtaat ccttaccaag ataacatact gtcctccaga ataccaagta   9720

ttaggtgaca ctagctcaag ctgttgtctt cagagcagtt accaagaagc tcggtgcaca   9780

ggttttctct ggttcttaca ggaaccacct actctttcag ttttctggcc caggagtggg   9840

gtaaatcctt tagttagtgc atttgaactt gatacctgtg cattcagttc tgtgaatact   9900

gccctttttg gcggggtttc ctcatctccc cagcctgaac tgctcaactc taaacccaaa   9960

ttagtgtcag ccgaaaggag gtttcaagat agtcctgtca gtatttgtgg tgaccttcag  10020

attagacagt cttcatttcc agccagtgga gtcctggctc cagagccatc tctgagactc  10080

gtactactgg atgttttaat atcagatcat tacccaccat atgcctccca caggccaagg  10140

gaaaacagac accagaactt gggttgaggg cactaccaga ctgacatggc cagtacagag  10200

gagaactagg gaaggaatga tgttttgcac cttattgaaa agaaaatttt aagtgcatac  10260

ataatagtta agagctttta ttgtgacagg agaacttttt tccatatgcg tgcatactct  10320

ctgtaattcc agtgtaaaat attgtacttg cactagcttt tttaaacaaa tattaaaaaa  10380

tggaagaatt catattctat tttctaatcg tggtgtgtct atttgtagga tacactcgag  10440

tctgtttatt gaattttatg gtccctttct ttgatggtgc ttgcaggttt tctaggtaga  10500

aattatttca ttattataat aaaacaatgt ttgattcaaa atttgaacaa aattgtttta  10560

aataaattgt ctgtatacca gtacaagttt attgtttcag tatactcgta ctaataaaat  10620

aacagtgcca attgcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa  10680

aaaaaaaaaa aa                                                      10692


<210>  324
<211>  815
<212>  PRT
<213>  Homo sapiens

<400>  324

Met Lys Ser Asn Gln Glu Arg Ser Asn Glu Cys Leu Pro Pro Lys Lys 
1               5                   10                  15


Arg Glu Ile Pro Ala Thr Ser Arg Ser Ser Glu Glu Lys Ala Pro Thr 
            20                  25                  30


Leu Pro Ser Asp Asn His Arg Val Glu Gly Thr Ala Trp Leu Pro Gly 
        35                  40                  45


Asn Pro Gly Gly Arg Gly His Gly Gly Gly Arg His Gly Pro Ala Gly 
    50                  55                  60


Thr Ser Val Glu Leu Gly Leu Gln Gln Gly Ile Gly Leu His Lys Ala 
65                  70                  75                  80


Leu Ser Thr Gly Leu Asp Tyr Ser Pro Pro Ser Ala Pro Arg Ser Val 
                85                  90                  95


Pro Val Ala Thr Thr Leu Pro Ala Ala Tyr Ala Thr Pro Gln Pro Gly 
            100                 105                 110


Thr Pro Val Ser Pro Val Gln Tyr Ala His Leu Pro His Thr Phe Gln 
        115                 120                 125


Phe Ile Gly Ser Ser Gln Tyr Ser Gly Thr Tyr Ala Ser Phe Ile Pro 
    130                 135                 140


Ser Gln Leu Ile Pro Pro Thr Ala Asn Pro Val Thr Ser Ala Val Ala 
145                 150                 155                 160


Ser Ala Ala Gly Ala Thr Thr Pro Ser Gln Arg Ser Gln Leu Glu Ala 
                165                 170                 175


Tyr Ser Thr Leu Leu Ala Asn Met Gly Ser Leu Ser Gln Thr Pro Gly 
            180                 185                 190


His Lys Ala Glu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        195                 200                 205


His Gln His Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    210                 215                 220


Gln His Leu Ser Arg Ala Pro Gly Leu Ile Thr Pro Gly Ser Pro Pro 
225                 230                 235                 240


Pro Ala Gln Gln Asn Gln Tyr Val His Ile Ser Ser Ser Pro Gln Asn 
                245                 250                 255


Thr Gly Arg Thr Ala Ser Pro Pro Ala Ile Pro Val His Leu His Pro 
            260                 265                 270


His Gln Thr Met Ile Pro His Thr Leu Thr Leu Gly Pro Pro Ser Gln 
        275                 280                 285


Val Val Met Gln Tyr Ala Asp Ser Gly Ser His Phe Val Pro Arg Glu 
    290                 295                 300


Ala Thr Lys Lys Ala Glu Ser Ser Arg Leu Gln Gln Ala Ile Gln Ala 
305                 310                 315                 320


Lys Glu Val Leu Asn Gly Glu Met Glu Lys Ser Arg Arg Tyr Gly Ala 
                325                 330                 335


Pro Ser Ser Ala Asp Leu Gly Leu Gly Lys Ala Gly Gly Lys Ser Val 
            340                 345                 350


Pro His Pro Tyr Glu Ser Arg His Val Val Val His Pro Ser Pro Ser 
        355                 360                 365


Asp Tyr Ser Ser Arg Asp Pro Ser Gly Val Arg Ala Ser Val Met Val 
    370                 375                 380


Leu Pro Asn Ser Asn Thr Pro Ala Ala Asp Leu Glu Val Gln Gln Ala 
385                 390                 395                 400


Thr His Arg Glu Ala Ser Pro Ser Thr Leu Asn Asp Lys Ser Gly Leu 
                405                 410                 415


His Leu Gly Lys Pro Gly His Arg Ser Tyr Ala Leu Ser Pro His Thr 
            420                 425                 430


Val Ile Gln Thr Thr His Ser Ala Ser Glu Pro Leu Pro Val Gly Leu 
        435                 440                 445


Pro Ala Thr Ala Phe Tyr Ala Gly Thr Gln Pro Pro Val Ile Gly Tyr 
    450                 455                 460


Leu Ser Gly Gln Gln Gln Ala Ile Thr Tyr Ala Gly Ser Leu Pro Gln 
465                 470                 475                 480


His Leu Val Ile Pro Gly Thr Gln Pro Leu Leu Ile Pro Val Gly Ser 
                485                 490                 495


Thr Asp Met Glu Ala Ser Gly Ala Ala Pro Ala Ile Val Thr Ser Ser 
            500                 505                 510


Pro Gln Phe Ala Ala Val Pro His Thr Phe Val Thr Thr Ala Leu Pro 
        515                 520                 525


Lys Ser Glu Asn Phe Asn Pro Glu Ala Leu Val Thr Gln Ala Ala Tyr 
    530                 535                 540


Pro Ala Met Val Gln Ala Gln Ile His Leu Pro Val Val Gln Ser Val 
545                 550                 555                 560


Ala Ser Pro Ala Ala Ala Pro Pro Thr Leu Pro Pro Tyr Phe Met Lys 
                565                 570                 575


Gly Ser Ile Ile Gln Leu Ala Asn Gly Glu Leu Lys Lys Val Glu Asp 
            580                 585                 590


Leu Lys Thr Glu Asp Phe Ile Gln Ser Ala Glu Ile Ser Asn Asp Leu 
        595                 600                 605


Lys Ile Asp Ser Ser Thr Val Glu Arg Ile Glu Asp Ser His Ser Pro 
    610                 615                 620


Gly Val Ala Val Ile Gln Phe Ala Val Gly Glu His Arg Ala Gln Val 
625                 630                 635                 640


Ser Val Glu Val Leu Val Glu Tyr Pro Phe Phe Val Phe Gly Gln Gly 
                645                 650                 655


Trp Ser Ser Cys Cys Pro Glu Arg Thr Ser Gln Leu Phe Asp Leu Pro 
            660                 665                 670


Cys Ser Lys Leu Ser Val Gly Asp Val Cys Ile Ser Leu Thr Leu Lys 
        675                 680                 685


Asn Leu Lys Asn Gly Ser Val Lys Lys Gly Gln Pro Val Asp Pro Ala 
    690                 695                 700


Ser Val Leu Leu Lys His Ser Lys Ala Asp Gly Leu Ala Gly Ser Arg 
705                 710                 715                 720


His Arg Tyr Ala Glu Gln Glu Asn Gly Ile Asn Gln Gly Ser Ala Gln 
                725                 730                 735


Met Leu Ser Glu Asn Gly Glu Leu Lys Phe Pro Glu Lys Met Gly Leu 
            740                 745                 750


Pro Ala Ala Pro Phe Leu Thr Lys Ile Glu Pro Ser Lys Pro Ala Ala 
        755                 760                 765


Thr Arg Lys Arg Arg Trp Ser Ala Pro Glu Ser Arg Lys Leu Glu Lys 
    770                 775                 780


Ser Glu Asp Glu Pro Pro Leu Thr Leu Pro Lys Pro Ser Leu Ile Pro 
785                 790                 795                 800


Gln Glu Val Lys Ile Cys Ile Glu Gly Arg Ser Asn Val Gly Lys 
                805                 810                 815


<210>  325
<211>  971
<212>  DNA
<213>  Homo sapiens

<400>  325
gattgcttga ggagagaagt atgtgatcag aaagcattct ttgtctatta actcctgccc     60

agcaaaagtg aaagaaaatt catgggagca tgcaagaaca aagagcacag caaagctgga    120

caaacacagc aatccaggca ggggatttcc aactcaactc tggtatgtaa gctgcatgca    180

aagtcctttt tctgtctctg gtttctggcc ccttgtctgc agagatggct cccaatgctt    240

cctgcctctg tgtgcatgtc cgttccgagg aatgggattt aatgaccttt gatgccaacc    300

catatgacag cgtgaaaaaa atcaaagaac atgtccggtc taagaccaag gttcctgtgc    360

aggaccaggt tcttttgctg ggctccaaga tcttaaagcc acggagaagc ctctcatctt    420

acggcattga caaagagaag accatccacc ttaccctgaa agtggtgaag cccagtgatg    480

aggagctgcc cttgtttctt gtggagtcag gtgatgaggc aaagaggcac ctcctccagg    540

tgcgaaggtc cagctcagtg gcacaagtga aagcaatgat cgagactaag acgggtataa    600

tccctgagac ccagattgtg acttgcaatg gaaagagact ggaagatggg aagatgatgg    660

cagattacgg catcagaaag ggcaacttac tcttcctggc atcttattgt attggagggt    720

gaccaccctg ggcatggggt gttggcaggg gtcaaaaagc ttatttcttt taatctctta    780

ctcaacgaac acatcttctg atgatttccc aaaattaatg agaatgagat gagtagagta    840

agatttgggt gggatgggta ggatgaagta tattgcccaa ctctatgttt ctttgattct    900

aacacaatta attaagtgac atgattttta ctaatgtatt actgagacta gtaaataaat    960

ttttaagcca a                                                         971


<210>  326
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  326

Met Ala Pro Asn Ala Ser Cys Leu Cys Val His Val Arg Ser Glu Glu 
1               5                   10                  15


Trp Asp Leu Met Thr Phe Asp Ala Asn Pro Tyr Asp Ser Val Lys Lys 
            20                  25                  30


Ile Lys Glu His Val Arg Ser Lys Thr Lys Val Pro Val Gln Asp Gln 
        35                  40                  45


Val Leu Leu Leu Gly Ser Lys Ile Leu Lys Pro Arg Arg Ser Leu Ser 
    50                  55                  60


Ser Tyr Gly Ile Asp Lys Glu Lys Thr Ile His Leu Thr Leu Lys Val 
65                  70                  75                  80


Val Lys Pro Ser Asp Glu Glu Leu Pro Leu Phe Leu Val Glu Ser Gly 
                85                  90                  95


Asp Glu Ala Lys Arg His Leu Leu Gln Val Arg Arg Ser Ser Ser Val 
            100                 105                 110


Ala Gln Val Lys Ala Met Ile Glu Thr Lys Thr Gly Ile Ile Pro Glu 
        115                 120                 125


Thr Gln Ile Val Thr Cys Asn Gly Lys Arg Leu Glu Asp Gly Lys Met 
    130                 135                 140


Met Ala Asp Tyr Gly Ile Arg Lys Gly Asn Leu Leu Phe Leu Ala Ser 
145                 150                 155                 160


Tyr Cys Ile Gly Gly 
                165


<210>  327
<211>  1063
<212>  DNA
<213>  Homo sapiens

<400>  327
tgacagcctc atccctccag gtacaaacaa gaacaggcca tggttaacca aagctccaca     60

ccgggcttcc tccttctggg cttctctgaa cacccagggc tggaaaggac tctcttcgtg    120

gttgtcctca cttcctacct cctaacccta gtgggcaaca cactcatcat cctgctgtct    180

gcgctggacc ccaagctcca ctctccaatg tactttttcc tctccaacct ctccttcttg    240

gacctctgtt tcaccacgag ttgtgttccc caaatgctgg tcaacctctg gggcccaaag    300

aagaccatca gcttcctgga ctgctctgtc cagatcttca tcttcctgtc cctggggaca    360

actgagtgca tcctcttgac agtgatggct tttgatcgct acgtggctgt ctgccagccc    420

ctccactatg ccaccatcat ccacccccgc ctgtgctggc agctggcatc tgtggcctgg    480

gtcattgggc tagtggagtc agtggtccag acaccatcca ccctgcacct gcccttctgc    540

cccgatcggc aggtggatga ttttgtctgt gaggtcccag ctctaattcg actctcctgt    600

gaagacacct cctacaatga gatccaggtg gctgttgcca gtgtcttcat cttggttgtg    660

cctctcagcc tcatccttgt ctcttacgga gccattacct gggcagtgct gaggattaac    720

tctgcaaaag ggcggaggaa agcttttggg acctgctcct cccatctcac tgtggtcacc    780

ctcttctaca gctcagtcat tgctgtctac ctccagccca aaaatcccta tgcccaagag    840

aggggcaagt tctttggtct cttctatgca gtgggcactc cttcacttaa ccctctcata    900

tacaccctga ggaacaagga ggtaaccagg gcattcagga gattgctggg gaaggaaatg    960

gggctcacac aaagctgagg gagagctgct taatgtgctt taaaagagag gagattctat   1020

gtgcttttat cagaaagttt gagttccctg cccctctgcc ttc                     1063


<210>  328
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  328

Met Val Asn Gln Ser Ser Thr Pro Gly Phe Leu Leu Leu Gly Phe Ser 
1               5                   10                  15


Glu His Pro Gly Leu Glu Arg Thr Leu Phe Val Val Val Leu Thr Ser 
            20                  25                  30


Tyr Leu Leu Thr Leu Val Gly Asn Thr Leu Ile Ile Leu Leu Ser Ala 
        35                  40                  45


Leu Asp Pro Lys Leu His Ser Pro Met Tyr Phe Phe Leu Ser Asn Leu 
    50                  55                  60


Ser Phe Leu Asp Leu Cys Phe Thr Thr Ser Cys Val Pro Gln Met Leu 
65                  70                  75                  80


Val Asn Leu Trp Gly Pro Lys Lys Thr Ile Ser Phe Leu Asp Cys Ser 
                85                  90                  95


Val Gln Ile Phe Ile Phe Leu Ser Leu Gly Thr Thr Glu Cys Ile Leu 
            100                 105                 110


Leu Thr Val Met Ala Phe Asp Arg Tyr Val Ala Val Cys Gln Pro Leu 
        115                 120                 125


His Tyr Ala Thr Ile Ile His Pro Arg Leu Cys Trp Gln Leu Ala Ser 
    130                 135                 140


Val Ala Trp Val Ile Gly Leu Val Glu Ser Val Val Gln Thr Pro Ser 
145                 150                 155                 160


Thr Leu His Leu Pro Phe Cys Pro Asp Arg Gln Val Asp Asp Phe Val 
                165                 170                 175


Cys Glu Val Pro Ala Leu Ile Arg Leu Ser Cys Glu Asp Thr Ser Tyr 
            180                 185                 190


Asn Glu Ile Gln Val Ala Val Ala Ser Val Phe Ile Leu Val Val Pro 
        195                 200                 205


Leu Ser Leu Ile Leu Val Ser Tyr Gly Ala Ile Thr Trp Ala Val Leu 
    210                 215                 220


Arg Ile Asn Ser Ala Lys Gly Arg Arg Lys Ala Phe Gly Thr Cys Ser 
225                 230                 235                 240


Ser His Leu Thr Val Val Thr Leu Phe Tyr Ser Ser Val Ile Ala Val 
                245                 250                 255


Tyr Leu Gln Pro Lys Asn Pro Tyr Ala Gln Glu Arg Gly Lys Phe Phe 
            260                 265                 270


Gly Leu Phe Tyr Ala Val Gly Thr Pro Ser Leu Asn Pro Leu Ile Tyr 
        275                 280                 285


Thr Leu Arg Asn Lys Glu Val Thr Arg Ala Phe Arg Arg Leu Leu Gly 
    290                 295                 300


Lys Glu Met Gly Leu Thr Gln Ser 
305                 310


<210>  329
<211>  4445
<212>  DNA
<213>  Homo sapiens

<400>  329
cgctccccgc tcccgtggct gccgccgccc cggggaagaa gagacagggg tggggtttgg     60

gggaagcgag agaggagggg agagaccctg gccaggctgg agcctggatt cgaggggagg    120

agggacggga ggaggagaaa ggtggaggag aagggagggg ggagcgggga ggagcggccg    180

ggcctggggc cttgaggccc ggggagagcc ggggagccgg gcccgcgcgc cgagatgttg    240

ctgctgctgt tactggcgcc actcttcctc cgccccccgg gcgcgggcgg ggcgcagacc    300

cccaacgcca cctcagaagg ttgccagatc atacacccgc cctgggaagg gggcatcagg    360

taccggggcc tgactcggga ccaggtgaag gctatcaact tcctgccagt ggactatgag    420

attgagtatg tgtgccgggg ggagcgcgag gtggtggggc ccaaggtccg caagtgcctg    480

gccaacggct cctggacaga tatggacaca cccagccgct gtgtccgaat ctgctccaag    540

tcttatttga ccctggaaaa tgggaaggtt ttcctgacgg gtggggacct cccagctctg    600

gacggagccc gggtggattt ccggtgtgac cccgacttcc atctggtggg cagctcccgg    660

agcatctgta gtcagggcca gtggagcacc cccaagcccc actgccaggt gaatcgaacg    720

ccacactcag aacggcgcgc agtgtacatc ggggcactgt ttcccatgag cgggggctgg    780

ccagggggcc aggcctgcca gcccgcggtg gagatggcgc tggaggacgt gaatagccgc    840

agggacatcc tgccggacta tgagctcaag ctcatccacc acgacagcaa gtgtgatcca    900

ggccaagcca ccaagtacct atatgagctg ctctacaacg accctatcaa gatcatcctt    960

atgcctggct gcagctctgt ctccacgctg gtggctgagg ctgctaggat gtggaacctc   1020

attgtgcttt cctatggctc cagctcacca gccctgtcaa accggcagcg tttccccact   1080

ttcttccgaa cgcacccatc agccacactc cacaacccta cccgcgtgaa actctttgaa   1140

aagtggggct ggaagaagat tgctaccatc cagcagacca ctgaggtctt cacttcgact   1200

ctggacgacc tggaggaacg agtgaaggag gctggaattg agattacttt ccgccagagt   1260

ttcttctcag atccagctgt gcccgtcaaa aacctgaagc gccaggatgc ccgaatcatc   1320

gtgggacttt tctatgagac tgaagcccgg aaagtttttt gtgaggtgta caaggagcgt   1380

ctctttggga agaagtacgt ctggttcctc attgggtggt atgctgacaa ttggttcaag   1440

atctacgacc cttctatcaa ctgcacagtg gatgagatga ctgaggcggt ggagggccac   1500

atcacaactg agattgtcat gctgaatcct gccaataccc gcagcatttc caacatgaca   1560

tcccaggaat ttgtggagaa actaaccaag cgactgaaaa gacaccctga ggagacagga   1620

ggcttccagg aggcaccgct ggcctatgat gccatctggg ccttggcact ggccctgaac   1680

aagacatctg gaggaggcgg ccgttctggt gtgcgcctgg aggacttcaa ctacaacaac   1740

cagaccatta ccgaccaaat ctaccgggca atgaactctt cgtcctttga gggtgtctct   1800

ggccatgtgg tgtttgatgc cagcggctct cggatggcat ggacgcttat cgagcagctt   1860

cagggtggca gctacaagaa gattggctac tatgacagca ccaaggatga tctttcctgg   1920

tccaaaacag ataaatggat tggagggtcc cccccagctg accagaccct ggtcatcaag   1980

acattccgct tcctgtcaca gaaactcttt atctccgtct cagttctctc cagcctgggc   2040

attgtcctag ctgttgtctg tctgtccttt aacatctaca actcacatgt ccgttatatc   2100

cagaactcac agcccaacct gaacaacctg actgctgtgg gctgctcact ggctttagct   2160

gctgtcttcc ccctggggct cgatggttac cacattggga ggaaccagtt tcctttcgtc   2220

tgccaggccc gcctctggct cctgggcctg ggctttagtc tgggctacgg ttccatgttc   2280

accaagattt ggtgggtcca cacggtcttc acaaagaagg aagaaaagaa ggagtggagg   2340

aagactctgg aaccctggaa gctgtatgcc acagtgggcc tgctggtggg catggatgtc   2400

ctcactctcg ccatctggca gatcgtggac cctctgcacc ggaccattga gacatttgcc   2460

aaggaggaac ctaaggaaga tattgacgtc tctattctgc cccagctgga gcattgcagc   2520

tccaggaaga tgaatacatg gcttggcatt ttctatggtt acaaggggct gctgctgctg   2580

ctgggaatct tccttgctta tgagaccaag agtgtgtcca ctgagaagat caatgatcac   2640

cgggctgtgg gcatggctat ctacaatgtg gcagtcctgt gcctcatcac tgctcctgtc   2700

accatgattc tgtccagcca gcaggatgca gcctttgcct ttgcctctct tgccatagtt   2760

ttctcctcct atatcactct tgttgtgctc tttgtgccca agatgcgcag gctgatcacc   2820

cgaggggaat ggcagtcgga ggcgcaggac accatgaaga cagggtcatc gaccaacaac   2880

aacgaggagg agaagtcccg gctgttggag aaggagaacc gtgaactgga aaagatcatt   2940

gctgagaaag aggagcgtgt ctctgaactg cgccatcaac tccagtctcg gcagcagctc   3000

cgctcccggc gccacccacc gacaccccca gaaccctctg ggggcctgcc caggggaccc   3060

cctgagcccc ccgaccggct tagctgtgat gggagtcgag tgcatttgct ttataagtga   3120

gggtagggtg agggaggaca ggccagtagg gggagggaaa gggagagggg aagggcaggg   3180

gactcaggaa gcagggggtc cccatcccca gctgggaaga acatgctatc caatctcatc   3240

tcttgtaaat acatgtcccc ctgtgagttc tgggctgatt tgggtctctc atacctctgg   3300

gaaacagacc tttttctctc ttactgcttc atgtaatttt gtatcacctc ttcacaattt   3360

agttcgtacc tggcttgaag ctgctcactg ctcacacgct gcctcctcag cagcctcact   3420

gcatctttct cttcccatgc aacaccctct tctagttacc acggcaaccc ctgcagctcc   3480

tctgcctttg tgctctgttc ctgtccagca ggggtctccc aacaagtgct ctttccaccc   3540

caaaggggcc tctccttttc tccactgtca taatctcttt ccatcttact tgcccttcta   3600

tactttctca catgtggctc cccctgaatt ttgcttcctt tgggagctca ttcttttcgc   3660

caaggctcac atgctccttg cctctgctct gtgcactcac gctcagcaca catgcatcct   3720

cccctctcct gcgtgtgccc actgaacatg ctcatgtgta cacacgcttt tcccgtatgc   3780

tttcttcatg ttcagtcaca tgtgctctcg ggtgccctgc attcacagct acgtgtgccc   3840

ctctcatggt catgggtctg cccttgagcg tgtttgggta ggcatgtgca atttgtctag   3900

catgctgagt catgtctttc ctatttgcac acgtccatgt ttatccatgt actttccctg   3960

tgtaccctcc atgtaccttg tgtactttct tcccttaaat catggtattc ttctgacaga   4020

gccatatgta ccctaccctg cacattgtta tgcacttttc cccaattcat gtttggtggg   4080

gccatccaca ccctctcctt gtcacagaat ctccatttct gctcagattc cccccatctc   4140

cattgcattc atgtactacc ctcagtctac actcacaatc atcttctccc aagactgctc   4200

ccttttgttt tgtgtttttt tgaggggaat taaggaaaaa taagtggggg caggtttgga   4260

gagctgcttc cagtggatag ttgatgagaa tcctgaccaa aggaaggcac ccttgactgt   4320

tgggatagac agatggacct atggggtggg aggtggtgtc cctttcacac tgtggtgtct   4380

cttggggaag gatctccccg aatctcaata aaccagtgaa cagtgtgact cggcaaaaaa   4440

aaaaa                                                               4445


<210>  330
<211>  961
<212>  PRT
<213>  Homo sapiens

<400>  330

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
1               5                   10                  15


Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
            20                  25                  30


Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
        35                  40                  45


Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
    50                  55                  60


Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
65                  70                  75                  80


Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                85                  90                  95


Val Arg Ile Cys Ser Lys Ser Tyr Leu Thr Leu Glu Asn Gly Lys Val 
            100                 105                 110


Phe Leu Thr Gly Gly Asp Leu Pro Ala Leu Asp Gly Ala Arg Val Asp 
        115                 120                 125


Phe Arg Cys Asp Pro Asp Phe His Leu Val Gly Ser Ser Arg Ser Ile 
    130                 135                 140


Cys Ser Gln Gly Gln Trp Ser Thr Pro Lys Pro His Cys Gln Val Asn 
145                 150                 155                 160


Arg Thr Pro His Ser Glu Arg Arg Ala Val Tyr Ile Gly Ala Leu Phe 
                165                 170                 175


Pro Met Ser Gly Gly Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val 
            180                 185                 190


Glu Met Ala Leu Glu Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp 
        195                 200                 205


Tyr Glu Leu Lys Leu Ile His His Asp Ser Lys Cys Asp Pro Gly Gln 
    210                 215                 220


Ala Thr Lys Tyr Leu Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile 
225                 230                 235                 240


Ile Leu Met Pro Gly Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala 
                245                 250                 255


Ala Arg Met Trp Asn Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro 
            260                 265                 270


Ala Leu Ser Asn Arg Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro 
        275                 280                 285


Ser Ala Thr Leu His Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp 
    290                 295                 300


Gly Trp Lys Lys Ile Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr 
305                 310                 315                 320


Ser Thr Leu Asp Asp Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu 
                325                 330                 335


Ile Thr Phe Arg Gln Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys 
            340                 345                 350


Asn Leu Lys Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu 
        355                 360                 365


Thr Glu Ala Arg Lys Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe 
    370                 375                 380


Gly Lys Lys Tyr Val Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp 
385                 390                 395                 400


Phe Lys Ile Tyr Asp Pro Ser Ile Asn Cys Thr Val Asp Glu Met Thr 
                405                 410                 415


Glu Ala Val Glu Gly His Ile Thr Thr Glu Ile Val Met Leu Asn Pro 
            420                 425                 430


Ala Asn Thr Arg Ser Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu 
        435                 440                 445


Lys Leu Thr Lys Arg Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe 
    450                 455                 460


Gln Glu Ala Pro Leu Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala 
465                 470                 475                 480


Leu Asn Lys Thr Ser Gly Gly Gly Gly Arg Ser Gly Val Arg Leu Glu 
                485                 490                 495


Asp Phe Asn Tyr Asn Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala 
            500                 505                 510


Met Asn Ser Ser Ser Phe Glu Gly Val Ser Gly His Val Val Phe Asp 
        515                 520                 525


Ala Ser Gly Ser Arg Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly 
    530                 535                 540


Gly Ser Tyr Lys Lys Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu 
545                 550                 555                 560


Ser Trp Ser Lys Thr Asp Lys Trp Ile Gly Gly Ser Pro Pro Ala Asp 
                565                 570                 575


Gln Thr Leu Val Ile Lys Thr Phe Arg Phe Leu Ser Gln Lys Leu Phe 
            580                 585                 590


Ile Ser Val Ser Val Leu Ser Ser Leu Gly Ile Val Leu Ala Val Val 
        595                 600                 605


Cys Leu Ser Phe Asn Ile Tyr Asn Ser His Val Arg Tyr Ile Gln Asn 
    610                 615                 620


Ser Gln Pro Asn Leu Asn Asn Leu Thr Ala Val Gly Cys Ser Leu Ala 
625                 630                 635                 640


Leu Ala Ala Val Phe Pro Leu Gly Leu Asp Gly Tyr His Ile Gly Arg 
                645                 650                 655


Asn Gln Phe Pro Phe Val Cys Gln Ala Arg Leu Trp Leu Leu Gly Leu 
            660                 665                 670


Gly Phe Ser Leu Gly Tyr Gly Ser Met Phe Thr Lys Ile Trp Trp Val 
        675                 680                 685


His Thr Val Phe Thr Lys Lys Glu Glu Lys Lys Glu Trp Arg Lys Thr 
    690                 695                 700


Leu Glu Pro Trp Lys Leu Tyr Ala Thr Val Gly Leu Leu Val Gly Met 
705                 710                 715                 720


Asp Val Leu Thr Leu Ala Ile Trp Gln Ile Val Asp Pro Leu His Arg 
                725                 730                 735


Thr Ile Glu Thr Phe Ala Lys Glu Glu Pro Lys Glu Asp Ile Asp Val 
            740                 745                 750


Ser Ile Leu Pro Gln Leu Glu His Cys Ser Ser Arg Lys Met Asn Thr 
        755                 760                 765


Trp Leu Gly Ile Phe Tyr Gly Tyr Lys Gly Leu Leu Leu Leu Leu Gly 
    770                 775                 780


Ile Phe Leu Ala Tyr Glu Thr Lys Ser Val Ser Thr Glu Lys Ile Asn 
785                 790                 795                 800


Asp His Arg Ala Val Gly Met Ala Ile Tyr Asn Val Ala Val Leu Cys 
                805                 810                 815


Leu Ile Thr Ala Pro Val Thr Met Ile Leu Ser Ser Gln Gln Asp Ala 
            820                 825                 830


Ala Phe Ala Phe Ala Ser Leu Ala Ile Val Phe Ser Ser Tyr Ile Thr 
        835                 840                 845


Leu Val Val Leu Phe Val Pro Lys Met Arg Arg Leu Ile Thr Arg Gly 
    850                 855                 860


Glu Trp Gln Ser Glu Ala Gln Asp Thr Met Lys Thr Gly Ser Ser Thr 
865                 870                 875                 880


Asn Asn Asn Glu Glu Glu Lys Ser Arg Leu Leu Glu Lys Glu Asn Arg 
                885                 890                 895


Glu Leu Glu Lys Ile Ile Ala Glu Lys Glu Glu Arg Val Ser Glu Leu 
            900                 905                 910


Arg His Gln Leu Gln Ser Arg Gln Gln Leu Arg Ser Arg Arg His Pro 
        915                 920                 925


Pro Thr Pro Pro Glu Pro Ser Gly Gly Leu Pro Arg Gly Pro Pro Glu 
    930                 935                 940


Pro Pro Asp Arg Leu Ser Cys Asp Gly Ser Arg Val His Leu Leu Tyr 
945                 950                 955                 960


Lys 



<210>  331
<211>  4039
<212>  DNA
<213>  Homo sapiens

<400>  331
agagccgcgg gggccgtagg aagccaacct tccctgcttc tccggggccc tcgccccctc     60

ctccccacaa aatcagggat ggaggcgcct ccccggcacc ctcttagcag ccctccccag    120

gaaaagtgtc ccccctgagc tcctaacgct ccccaacagc tacccctgcc ccccacgcca    180

tggggcccgg ggcccctttt gcccgggtgg ggtggccact gccgcttctg gttgtgatgg    240

cggcaggggt ggctccggtg tgggcctccc actcccccca tctcccgcgg cctcactcgc    300

gggtcccccc gcacccctcc tcagaacggc gcgcagtgta catcggggca ctgtttccca    360

tgagcggggg ctggccaggg ggccaggcct gccagcccgc ggtggagatg gcgctggagg    420

acgtgaatag ccgcagggac atcctgccgg actatgagct caagctcatc caccacgaca    480

gcaagtgtga tccaggccaa gccaccaagt acctatatga gctgctctac aacgacccta    540

tcaagatcat ccttatgcct ggctgcagct ctgtctccac gctggtggct gaggctgcta    600

ggatgtggaa cctcattgtg ctttcctatg gctccagctc accagccctg tcaaaccggc    660

agcgtttccc cactttcttc cgaacgcacc catcagccac actccacaac cctacccgcg    720

tgaaactctt tgaaaagtgg ggctggaaga agattgctac catccagcag accactgagg    780

tcttcacttc gactctggac gacctggagg aacgagtgaa ggaggctgga attgagatta    840

ctttccgcca gagtttcttc tcagatccag ctgtgcccgt caaaaacctg aagcgccagg    900

atgcccgaat catcgtggga cttttctatg agactgaagc ccggaaagtt ttttgtgagg    960

tgtacaagga gcgtctcttt gggaagaagt acgtctggtt cctcattggg tggtatgctg   1020

acaattggtt caagatctac gacccttcta tcaactgcac agtggatgag atgactgagg   1080

cggtggaggg ccacatcaca actgagattg tcatgctgaa tcctgccaat acccgcagca   1140

tttccaacat gacatcccag gaatttgtgg agaaactaac caagcgactg aaaagacacc   1200

ctgaggagac aggaggcttc caggaggcac cgctggccta tgatgccatc tgggccttgg   1260

cactggccct gaacaagaca tctggaggag gcggccgttc tggtgtgcgc ctggaggact   1320

tcaactacaa caaccagacc attaccgacc aaatctaccg ggcaatgaac tcttcgtcct   1380

ttgagggtgt ctctggccat gtggtgtttg atgccagcgg ctctcggatg gcatggacgc   1440

ttatcgagca gcttcagggt ggcagctaca agaagattgg ctactatgac agcaccaagg   1500

atgatctttc ctggtccaaa acagataaat ggattggagg gtccccccca gctgaccaga   1560

ccctggtcat caagacattc cgcttcctgt cacagaaact ctttatctcc gtctcagttc   1620

tctccagcct gggcattgtc ctagctgttg tctgtctgtc ctttaacatc tacaactcac   1680

atgtccgtta tatccagaac tcacagccca acctgaacaa cctgactgct gtgggctgct   1740

cactggcttt agctgctgtc ttccccctgg ggctcgatgg ttaccacatt gggaggaacc   1800

agtttccttt cgtctgccag gcccgcctct ggctcctggg cctgggcttt agtctgggct   1860

acggttccat gttcaccaag atttggtggg tccacacggt cttcacaaag aaggaagaaa   1920

agaaggagtg gaggaagact ctggaaccct ggaagctgta tgccacagtg ggcctgctgg   1980

tgggcatgga tgtcctcact ctcgccatct ggcagatcgt ggaccctctg caccggacca   2040

ttgagacatt tgccaaggag gaacctaagg aagatattga cgtctctatt ctgccccagc   2100

tggagcattg cagctccagg aagatgaata catggcttgg cattttctat ggttacaagg   2160

ggctgctgct gctgctggga atcttccttg cttatgagac caagagtgtg tccactgaga   2220

agatcaatga tcaccgggct gtgggcatgg ctatctacaa tgtggcagtc ctgtgcctca   2280

tcactgctcc tgtcaccatg attctgtcca gccagcagga tgcagccttt gcctttgcct   2340

ctcttgccat agttttctcc tcctatatca ctcttgttgt gctctttgtg cccaagatgc   2400

gcaggctgat cacccgaggg gaatggcagt cggaggcgca ggacaccatg aagacagggt   2460

catcgaccaa caacaacgag gaggagaagt cccggctgtt ggagaaggag aaccgtgaac   2520

tggaaaagat cattgctgag aaagaggagc gtgtctctga actgcgccat caactccagt   2580

ctcggcagca gctccgctcc cggcgccacc caccgacacc cccagaaccc tctgggggcc   2640

tgcccagggg accccctgag ccccccgacc ggcttagctg tgatgggagt cgagtgcatt   2700

tgctttataa gtgagggtag ggtgagggag gacaggccag tagggggagg gaaagggaga   2760

ggggaagggc aggggactca ggaagcaggg ggtccccatc cccagctggg aagaacatgc   2820

tatccaatct catctcttgt aaatacatgt ccccctgtga gttctgggct gatttgggtc   2880

tctcatacct ctgggaaaca gacctttttc tctcttactg cttcatgtaa ttttgtatca   2940

cctcttcaca atttagttcg tacctggctt gaagctgctc actgctcaca cgctgcctcc   3000

tcagcagcct cactgcatct ttctcttccc atgcaacacc ctcttctagt taccacggca   3060

acccctgcag ctcctctgcc tttgtgctct gttcctgtcc agcaggggtc tcccaacaag   3120

tgctctttcc accccaaagg ggcctctcct tttctccact gtcataatct ctttccatct   3180

tacttgccct tctatacttt ctcacatgtg gctccccctg aattttgctt cctttgggag   3240

ctcattcttt tcgccaaggc tcacatgctc cttgcctctg ctctgtgcac tcacgctcag   3300

cacacatgca tcctcccctc tcctgcgtgt gcccactgaa catgctcatg tgtacacacg   3360

cttttcccgt atgctttctt catgttcagt cacatgtgct ctcgggtgcc ctgcattcac   3420

agctacgtgt gcccctctca tggtcatggg tctgcccttg agcgtgtttg ggtaggcatg   3480

tgcaatttgt ctagcatgct gagtcatgtc tttcctattt gcacacgtcc atgtttatcc   3540

atgtactttc cctgtgtacc ctccatgtac cttgtgtact ttcttccctt aaatcatggt   3600

attcttctga cagagccata tgtaccctac cctgcacatt gttatgcact tttccccaat   3660

tcatgtttgg tggggccatc cacaccctct ccttgtcaca gaatctccat ttctgctcag   3720

attcccccca tctccattgc attcatgtac taccctcagt ctacactcac aatcatcttc   3780

tcccaagact gctccctttt gttttgtgtt tttttgaggg gaattaagga aaaataagtg   3840

ggggcaggtt tggagagctg cttccagtgg atagttgatg agaatcctga ccaaaggaag   3900

gcacccttga ctgttgggat agacagatgg acctatgggg tgggaggtgg tgtccctttc   3960

acactgtggt gtctcttggg gaaggatctc cccgaatctc aataaaccag tgaacagtgt   4020

gactcggcaa aaaaaaaaa                                                4039


<210>  332
<211>  844
<212>  PRT
<213>  Homo sapiens

<400>  332

Met Gly Pro Gly Ala Pro Phe Ala Arg Val Gly Trp Pro Leu Pro Leu 
1               5                   10                  15


Leu Val Val Met Ala Ala Gly Val Ala Pro Val Trp Ala Ser His Ser 
            20                  25                  30


Pro His Leu Pro Arg Pro His Ser Arg Val Pro Pro His Pro Ser Ser 
        35                  40                  45


Glu Arg Arg Ala Val Tyr Ile Gly Ala Leu Phe Pro Met Ser Gly Gly 
    50                  55                  60


Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val Glu Met Ala Leu Glu 
65                  70                  75                  80


Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp Tyr Glu Leu Lys Leu 
                85                  90                  95


Ile His His Asp Ser Lys Cys Asp Pro Gly Gln Ala Thr Lys Tyr Leu 
            100                 105                 110


Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile Ile Leu Met Pro Gly 
        115                 120                 125


Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala Ala Arg Met Trp Asn 
    130                 135                 140


Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro Ala Leu Ser Asn Arg 
145                 150                 155                 160


Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro Ser Ala Thr Leu His 
                165                 170                 175


Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp Gly Trp Lys Lys Ile 
            180                 185                 190


Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr Ser Thr Leu Asp Asp 
        195                 200                 205


Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu Ile Thr Phe Arg Gln 
    210                 215                 220


Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys Asn Leu Lys Arg Gln 
225                 230                 235                 240


Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu Thr Glu Ala Arg Lys 
                245                 250                 255


Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe Gly Lys Lys Tyr Val 
            260                 265                 270


Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp Phe Lys Ile Tyr Asp 
        275                 280                 285


Pro Ser Ile Asn Cys Thr Val Asp Glu Met Thr Glu Ala Val Glu Gly 
    290                 295                 300


His Ile Thr Thr Glu Ile Val Met Leu Asn Pro Ala Asn Thr Arg Ser 
305                 310                 315                 320


Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu Lys Leu Thr Lys Arg 
                325                 330                 335


Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe Gln Glu Ala Pro Leu 
            340                 345                 350


Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala Leu Asn Lys Thr Ser 
        355                 360                 365


Gly Gly Gly Gly Arg Ser Gly Val Arg Leu Glu Asp Phe Asn Tyr Asn 
    370                 375                 380


Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala Met Asn Ser Ser Ser 
385                 390                 395                 400


Phe Glu Gly Val Ser Gly His Val Val Phe Asp Ala Ser Gly Ser Arg 
                405                 410                 415


Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly Gly Ser Tyr Lys Lys 
            420                 425                 430


Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu Ser Trp Ser Lys Thr 
        435                 440                 445


Asp Lys Trp Ile Gly Gly Ser Pro Pro Ala Asp Gln Thr Leu Val Ile 
    450                 455                 460


Lys Thr Phe Arg Phe Leu Ser Gln Lys Leu Phe Ile Ser Val Ser Val 
465                 470                 475                 480


Leu Ser Ser Leu Gly Ile Val Leu Ala Val Val Cys Leu Ser Phe Asn 
                485                 490                 495


Ile Tyr Asn Ser His Val Arg Tyr Ile Gln Asn Ser Gln Pro Asn Leu 
            500                 505                 510


Asn Asn Leu Thr Ala Val Gly Cys Ser Leu Ala Leu Ala Ala Val Phe 
        515                 520                 525


Pro Leu Gly Leu Asp Gly Tyr His Ile Gly Arg Asn Gln Phe Pro Phe 
    530                 535                 540


Val Cys Gln Ala Arg Leu Trp Leu Leu Gly Leu Gly Phe Ser Leu Gly 
545                 550                 555                 560


Tyr Gly Ser Met Phe Thr Lys Ile Trp Trp Val His Thr Val Phe Thr 
                565                 570                 575


Lys Lys Glu Glu Lys Lys Glu Trp Arg Lys Thr Leu Glu Pro Trp Lys 
            580                 585                 590


Leu Tyr Ala Thr Val Gly Leu Leu Val Gly Met Asp Val Leu Thr Leu 
        595                 600                 605


Ala Ile Trp Gln Ile Val Asp Pro Leu His Arg Thr Ile Glu Thr Phe 
    610                 615                 620


Ala Lys Glu Glu Pro Lys Glu Asp Ile Asp Val Ser Ile Leu Pro Gln 
625                 630                 635                 640


Leu Glu His Cys Ser Ser Arg Lys Met Asn Thr Trp Leu Gly Ile Phe 
                645                 650                 655


Tyr Gly Tyr Lys Gly Leu Leu Leu Leu Leu Gly Ile Phe Leu Ala Tyr 
            660                 665                 670


Glu Thr Lys Ser Val Ser Thr Glu Lys Ile Asn Asp His Arg Ala Val 
        675                 680                 685


Gly Met Ala Ile Tyr Asn Val Ala Val Leu Cys Leu Ile Thr Ala Pro 
    690                 695                 700


Val Thr Met Ile Leu Ser Ser Gln Gln Asp Ala Ala Phe Ala Phe Ala 
705                 710                 715                 720


Ser Leu Ala Ile Val Phe Ser Ser Tyr Ile Thr Leu Val Val Leu Phe 
                725                 730                 735


Val Pro Lys Met Arg Arg Leu Ile Thr Arg Gly Glu Trp Gln Ser Glu 
            740                 745                 750


Ala Gln Asp Thr Met Lys Thr Gly Ser Ser Thr Asn Asn Asn Glu Glu 
        755                 760                 765


Glu Lys Ser Arg Leu Leu Glu Lys Glu Asn Arg Glu Leu Glu Lys Ile 
    770                 775                 780


Ile Ala Glu Lys Glu Glu Arg Val Ser Glu Leu Arg His Gln Leu Gln 
785                 790                 795                 800


Ser Arg Gln Gln Leu Arg Ser Arg Arg His Pro Pro Thr Pro Pro Glu 
                805                 810                 815


Pro Ser Gly Gly Leu Pro Arg Gly Pro Pro Glu Pro Pro Asp Arg Leu 
            820                 825                 830


Ser Cys Asp Gly Ser Arg Val His Leu Leu Tyr Lys 
        835                 840


<210>  333
<211>  4260
<212>  DNA
<213>  Homo sapiens

<400>  333
cgctccccgc tcccgtggct gccgccgccc cggggaagaa gagacagggg tggggtttgg     60

gggaagcgag agaggagggg agagaccctg gccaggctgg agcctggatt cgaggggagg    120

agggacggga ggaggagaaa ggtggaggag aagggagggg ggagcgggga ggagcggccg    180

ggcctggggc cttgaggccc ggggagagcc ggggagccgg gcccgcgcgc cgagatgttg    240

ctgctgctgc tactggcgcc actcttcctc cgccccccgg gcgcgggcgg ggcgcatacc    300

cccaacgcca cctcagaagg ttgccagatc atacacccgc cctgggaagg gggcatcagg    360

taccggggcc tgactcggga ccaggtgaag gctatcaact tcctgccagt ggactatgag    420

attgagtatg tgtgccgggg ggagcgcgag gtggtggggc ccaaggtccg caagtgcctg    480

gccaacggct cctggacaga tatggacaca cccagccgct gtgtgaatcg aacgccacac    540

tcagaacggc gcgcagtgta catcggggca ctgtttccca tgagcggggg ctggccaggg    600

ggccaggcct gccagcccgc ggtggagatg gcgctggagg acgtgaatag ccgcagggac    660

atcctgccgg actatgagct caagctcatc caccacgaca gcaagtgtga tccaggccaa    720

gccaccaagt acctatatga gctgctctac aacgacccta tcaagatcat ccttatgcct    780

ggctgcagct ctgtctccac gctggtggct gaggctgcta ggatgtggaa cctcattgtg    840

ctttcctatg gctccagctc accagccctg tcaaaccggc agcgtttccc cactttcttc    900

cgaacgcacc catcagccac actccacaac cctacccgcg tgaaactctt tgaaaagtgg    960

ggctggaaga agattgctac catccagcag accactgagg tcttcacttc gactctggac   1020

gacctggagg aacgagtgaa ggaggctgga attgagatta ctttccgcca gagtttcttc   1080

tcagatccag ctgtgcccgt caaaaacctg aagcgccagg atgcccgaat catcgtggga   1140

cttttctatg agactgaagc ccggaaagtt ttttgtgagg tgtacaagga gcgtctcttt   1200

gggaagaagt acgtctggtt cctcattggg tggtatgctg acaattggtt caagatctac   1260

gacccttcta tcaactgcac agtggatgag atgactgagg cggtggaggg ccacatcaca   1320

actgagattg tcatgctgaa tcctgccaat acccgcagca tttccaacat gacatcccag   1380

gaatttgtgg agaaactaac caagcgactg aaaagacacc ctgaggagac aggaggcttc   1440

caggaggcac cgctggccta tgatgccatc tgggccttgg cactggccct gaacaagaca   1500

tctggaggag gcggccgttc tggtgtgcgc ctggaggact tcaactacaa caaccagacc   1560

attaccgacc aaatctaccg ggcaatgaac tcttcgtcct ttgagggtgt ctctggccat   1620

gtggtgtttg atgccagcgg ctctcggatg gcatggacgc ttatcgagca gcttcagggt   1680

ggcagctaca agaagattgg ctactatgac agcaccaagg atgatctttc ctggtccaaa   1740

acagataaat ggattggagg gtccccccca gctgaccaga ccctggtcat caagacattc   1800

cgcttcctgt cacagaaact ctttatctcc gtctcagttc tctccagcct gggcattgtc   1860

ctagctgttg tctgtctgtc ctttaacatc tacaactcac atgtccgtta tatccagaac   1920

tcacagccca acctgaacaa cctgactgct gtgggctgct cactggcttt agctgctgtc   1980

ttccccctgg ggctcgatgg ttaccacatt gggaggaacc agtttccttt cgtctgccag   2040

gcccgcctct ggctcctggg cctgggcttt agtctgggct acggttccat gttcaccaag   2100

atttggtggg tccacacggt cttcacaaag aaggaagaaa agaaggagtg gaggaagact   2160

ctggaaccct ggaagctgta tgccacagtg ggcctgctgg tgggcatgga tgtcctcact   2220

ctcgccatct ggcagatcgt ggaccctctg caccggacca ttgagacatt tgccaaggag   2280

gaacctaagg aagatattga cgtctctatt ctgccccagc tggagcattg cagctccagg   2340

aagatgaata catggcttgg cattttctat ggttacaagg ggctgctgct gctgctggga   2400

atcttccttg cttatgagac caagagtgtg tccactgaga agatcaatga tcaccgggct   2460

gtgggcatgg ctatctacaa tgtggcagtc ctgtgcctca tcactgctcc tgtcaccatg   2520

attctgtcca gccagcagga tgcagccttt gcctttgcct ctcttgccat agttttctcc   2580

tcctatatca ctcttgttgt gctctttgtg cccaagatgc gcaggctgat cacccgaggg   2640

gaatggcagt cggaggcgca ggacaccatg aagacagggt catcgaccaa caacaacgag   2700

gaggagaagt cccggctgtt ggagaaggag aaccgtgaac tggaaaagat cattgctgag   2760

aaagaggagc gtgtctctga actgcgccat caactccagt ctcggcagca gctccgctcc   2820

cggcgccacc caccgacacc cccagaaccc tctgggggcc tgcccagggg accccctgag   2880

ccccccgacc ggcttagctg tgatgggagt cgagtgcatt tgctttataa gtgagggtag   2940

ggtgagggag gacaggccag tagggggagg gaaagggaga ggggaagggc aggggactca   3000

ggaagcaggg ggtccccatc cccagctggg aagaacatgc tatccaatct catctcttgt   3060

aaatacatgt ccccctgtga gttctgggct gatttgggtc tctcatacct ctgggaaaca   3120

gacctttttc tctcttactg cttcatgtaa ttttgtatca cctcttcaca atttagttcg   3180

tacctggctt gaagctgctc actgctcaca cgctgcctcc tcagcagcct cactgcatct   3240

ttctcttccc atgcaacacc ctcttctagt taccacggca acccctgcag ctcctctgcc   3300

tttgtgctct gttcctgtcc agcaggggtc tcccaacaag tgctctttcc accccaaagg   3360

ggcctctcct tttctccact gtcataatct ctttccatct tacttgccct tctatacttt   3420

ctcacatgtg gctccccctg aattttgctt cctttgggag ctcattcttt tcgccaaggc   3480

tcacatgctc cttgcctctg ctctgtgcac tcacgctcag cacacatgca tcctcccctc   3540

tcctgcgtgt gcccactgaa catgctcatg tgtacacacg cttttcccgt atgctttctt   3600

catgttcagt cacatgtgct ctcgggtgcc ctgcattcac agctacgtgt gcccctctca   3660

tggtcatggg tctgcccttg agcgtgtttg ggtaggcatg tgcaatttgt ctagcatgct   3720

gagtcatgtc tttcctattt gcacacgtcc atgtttatcc atgtactttc cctgtgtacc   3780

ctccatgtac cttgtgtact ttcttccctt aaatcatggt attcttctga cagagccata   3840

tgtaccctac cctgcacatt gttatgcact tttccccaat tcatgtttgg tggggccatc   3900

cacaccctct ccttgtcaca gaatctccat ttctgctcag attcccccca tctccattgc   3960

attcatgtac taccctcagt ctacactcac aatcatcttc tcccaagact gctccctttt   4020

gttttgtgtt tttttgaggg gaattaagga aaaataagtg ggggcaggtt tggagagctg   4080

cttccagtgg atagttgatg agaatcctga ccaaaggaag gcacccttga ctgttgggat   4140

agacagatgg acctatgggg tgggaggtgg tgtccctttc acactgtggt gtctcttggg   4200

gaaggatctc cccgaatctc aataaaccag tgaacagtgt gactcggcaa aaaaaaaaaa   4260


<210>  334
<211>  899
<212>  PRT
<213>  Homo sapiens

<400>  334

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
1               5                   10                  15


Ala Gly Gly Ala His Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
            20                  25                  30


Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
        35                  40                  45


Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
    50                  55                  60


Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
65                  70                  75                  80


Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                85                  90                  95


Val Asn Arg Thr Pro His Ser Glu Arg Arg Ala Val Tyr Ile Gly Ala 
            100                 105                 110


Leu Phe Pro Met Ser Gly Gly Trp Pro Gly Gly Gln Ala Cys Gln Pro 
        115                 120                 125


Ala Val Glu Met Ala Leu Glu Asp Val Asn Ser Arg Arg Asp Ile Leu 
    130                 135                 140


Pro Asp Tyr Glu Leu Lys Leu Ile His His Asp Ser Lys Cys Asp Pro 
145                 150                 155                 160


Gly Gln Ala Thr Lys Tyr Leu Tyr Glu Leu Leu Tyr Asn Asp Pro Ile 
                165                 170                 175


Lys Ile Ile Leu Met Pro Gly Cys Ser Ser Val Ser Thr Leu Val Ala 
            180                 185                 190


Glu Ala Ala Arg Met Trp Asn Leu Ile Val Leu Ser Tyr Gly Ser Ser 
        195                 200                 205


Ser Pro Ala Leu Ser Asn Arg Gln Arg Phe Pro Thr Phe Phe Arg Thr 
    210                 215                 220


His Pro Ser Ala Thr Leu His Asn Pro Thr Arg Val Lys Leu Phe Glu 
225                 230                 235                 240


Lys Trp Gly Trp Lys Lys Ile Ala Thr Ile Gln Gln Thr Thr Glu Val 
                245                 250                 255


Phe Thr Ser Thr Leu Asp Asp Leu Glu Glu Arg Val Lys Glu Ala Gly 
            260                 265                 270


Ile Glu Ile Thr Phe Arg Gln Ser Phe Phe Ser Asp Pro Ala Val Pro 
        275                 280                 285


Val Lys Asn Leu Lys Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe 
    290                 295                 300


Tyr Glu Thr Glu Ala Arg Lys Val Phe Cys Glu Val Tyr Lys Glu Arg 
305                 310                 315                 320


Leu Phe Gly Lys Lys Tyr Val Trp Phe Leu Ile Gly Trp Tyr Ala Asp 
                325                 330                 335


Asn Trp Phe Lys Ile Tyr Asp Pro Ser Ile Asn Cys Thr Val Asp Glu 
            340                 345                 350


Met Thr Glu Ala Val Glu Gly His Ile Thr Thr Glu Ile Val Met Leu 
        355                 360                 365


Asn Pro Ala Asn Thr Arg Ser Ile Ser Asn Met Thr Ser Gln Glu Phe 
    370                 375                 380


Val Glu Lys Leu Thr Lys Arg Leu Lys Arg His Pro Glu Glu Thr Gly 
385                 390                 395                 400


Gly Phe Gln Glu Ala Pro Leu Ala Tyr Asp Ala Ile Trp Ala Leu Ala 
                405                 410                 415


Leu Ala Leu Asn Lys Thr Ser Gly Gly Gly Gly Arg Ser Gly Val Arg 
            420                 425                 430


Leu Glu Asp Phe Asn Tyr Asn Asn Gln Thr Ile Thr Asp Gln Ile Tyr 
        435                 440                 445


Arg Ala Met Asn Ser Ser Ser Phe Glu Gly Val Ser Gly His Val Val 
    450                 455                 460


Phe Asp Ala Ser Gly Ser Arg Met Ala Trp Thr Leu Ile Glu Gln Leu 
465                 470                 475                 480


Gln Gly Gly Ser Tyr Lys Lys Ile Gly Tyr Tyr Asp Ser Thr Lys Asp 
                485                 490                 495


Asp Leu Ser Trp Ser Lys Thr Asp Lys Trp Ile Gly Gly Ser Pro Pro 
            500                 505                 510


Ala Asp Gln Thr Leu Val Ile Lys Thr Phe Arg Phe Leu Ser Gln Lys 
        515                 520                 525


Leu Phe Ile Ser Val Ser Val Leu Ser Ser Leu Gly Ile Val Leu Ala 
    530                 535                 540


Val Val Cys Leu Ser Phe Asn Ile Tyr Asn Ser His Val Arg Tyr Ile 
545                 550                 555                 560


Gln Asn Ser Gln Pro Asn Leu Asn Asn Leu Thr Ala Val Gly Cys Ser 
                565                 570                 575


Leu Ala Leu Ala Ala Val Phe Pro Leu Gly Leu Asp Gly Tyr His Ile 
            580                 585                 590


Gly Arg Asn Gln Phe Pro Phe Val Cys Gln Ala Arg Leu Trp Leu Leu 
        595                 600                 605


Gly Leu Gly Phe Ser Leu Gly Tyr Gly Ser Met Phe Thr Lys Ile Trp 
    610                 615                 620


Trp Val His Thr Val Phe Thr Lys Lys Glu Glu Lys Lys Glu Trp Arg 
625                 630                 635                 640


Lys Thr Leu Glu Pro Trp Lys Leu Tyr Ala Thr Val Gly Leu Leu Val 
                645                 650                 655


Gly Met Asp Val Leu Thr Leu Ala Ile Trp Gln Ile Val Asp Pro Leu 
            660                 665                 670


His Arg Thr Ile Glu Thr Phe Ala Lys Glu Glu Pro Lys Glu Asp Ile 
        675                 680                 685


Asp Val Ser Ile Leu Pro Gln Leu Glu His Cys Ser Ser Arg Lys Met 
    690                 695                 700


Asn Thr Trp Leu Gly Ile Phe Tyr Gly Tyr Lys Gly Leu Leu Leu Leu 
705                 710                 715                 720


Leu Gly Ile Phe Leu Ala Tyr Glu Thr Lys Ser Val Ser Thr Glu Lys 
                725                 730                 735


Ile Asn Asp His Arg Ala Val Gly Met Ala Ile Tyr Asn Val Ala Val 
            740                 745                 750


Leu Cys Leu Ile Thr Ala Pro Val Thr Met Ile Leu Ser Ser Gln Gln 
        755                 760                 765


Asp Ala Ala Phe Ala Phe Ala Ser Leu Ala Ile Val Phe Ser Ser Tyr 
    770                 775                 780


Ile Thr Leu Val Val Leu Phe Val Pro Lys Met Arg Arg Leu Ile Thr 
785                 790                 795                 800


Arg Gly Glu Trp Gln Ser Glu Ala Gln Asp Thr Met Lys Thr Gly Ser 
                805                 810                 815


Ser Thr Asn Asn Asn Glu Glu Glu Lys Ser Arg Leu Leu Glu Lys Glu 
            820                 825                 830


Asn Arg Glu Leu Glu Lys Ile Ile Ala Glu Lys Glu Glu Arg Val Ser 
        835                 840                 845


Glu Leu Arg His Gln Leu Gln Ser Arg Gln Gln Leu Arg Ser Arg Arg 
    850                 855                 860


His Pro Pro Thr Pro Pro Glu Pro Ser Gly Gly Leu Pro Arg Gly Pro 
865                 870                 875                 880


Pro Glu Pro Pro Asp Arg Leu Ser Cys Asp Gly Ser Arg Val His Leu 
                885                 890                 895


Leu Tyr Lys 



<210>  335
<211>  4294
<212>  DNA
<213>  Homo sapiens

<400>  335
cgctccccgc tcccgtggct gccgccgccc cggggaagaa gagacagggg tggggtttgg     60

gggaagcgag agaggagggg agagaccctg gccaggctgg agcctggatt cgaggggagg    120

agggacggga ggaggagaaa ggtggaggag aagggagggg ggagcgggga ggagcggccg    180

ggcctggggc cttgaggccc ggggagagcc ggggagccgg gcccgcgcgc cgagatgttg    240

ctgctgctgc tactggcgcc actcttcctc cgccccccgg gcgcgggcgg ggcgcagacc    300

cccaacgcca cctcagaagg ttgccagatc atacacccgc cctgggaagg gggcatcagg    360

taccggggcc tgactcggga ccaggtgaag gctatcaact tcctgccagt ggactatgag    420

attgagtatg tgtgccgggg ggagcgcgag gtggtggggc ccaaggtccg caagtgcctg    480

gccaacggct cctggacaga tatggacaca cccagccgct gtgtccgaat ctgctccaag    540

tcttatttga ccctggaaaa tgggaaggtt ttcctgacgg gtggggacct cccagctctg    600

gacggagccc gggtggattt ccggtgtgac cccgacttcc atctggtggg cagctcccgg    660

agcatctgta gtcagggcca gtggagcacc cccaagcccc actgccaggt gaatcgaacg    720

ccacactcag aacggcgcgc agtgtacatc ggggcactgt ttcccatgag cgggggctgg    780

ccagggggcc aggcctgcca gcccgcggtg gagatggcgc tggaggacgt gaatagccgc    840

agggacatcc tgccggacta tgagctcaag ctcatccacc acgacagcaa gtgtgatcca    900

ggccaagcca ccaagtacct atatgagctg ctctacaacg accctatcaa gatcatcctt    960

atgcctggct gcagctctgt ctccacgctg gtggctgagg ctgctaggat gtggaacctc   1020

attgtgcttt cctatggctc cagctcacca gccctgtcaa accggcagcg tttccccact   1080

ttcttccgaa cgcacccatc agccacactc cacaacccta cccgcgtgaa actctttgaa   1140

aagtggggct ggaagaagat tgctaccatc cagcagacca ctgaggtctt cacttcgact   1200

ctggacgacc tggaggaacg agtgaaggag gctggaattg agattacttt ccgccagagt   1260

ttcttctcag atccagctgt gcccgtcaaa aacctgaagc gccaggatgc ccgaatcatc   1320

gtgggacttt tctatgagac tgaagcccgg aaagtttttt gtgaggtgta caaggagcgt   1380

ctctttggga agaagtacgt ctggttcctc attgggtggt atgctgacaa ttggttcaag   1440

atctacgacc cttctatcaa ctgcacagtg gatgagatga ctgaggcggt ggagggccac   1500

atcacaactg agatcgtcat gctgaatcct gccaataccc gcagcatttc caacatgaca   1560

tcccaggaat ttgtggagaa actaaccaag cgactgaaaa gacaccctga ggagacagga   1620

ggcttccagg aggcaccgct ggcctatgat gccatctggg ccttggcact ggccctgaac   1680

aagacatctg gaggaggcag ccgttccggc gtgcgcctgg aggacttcaa ctacaacaac   1740

cagaccatta ccgaccaaat ctaccgggca atgaactcct cgtcctttga gggtgtctct   1800

ggccatgtgg tgtttgatgc cagcggctct cggatggcat ggacgcttat cgagcagctt   1860

cagggtggca gctacaagaa gattggctac tatgacagca ccaaggatga tctttcctgg   1920

tccaaaacag ataaatggat tgttatatcc agaactcaca gcccaacctg acaacctgac   1980

tgctgtgggc tgctcactgg ctttagctgc tgtcttcccc ctggggctcg atggttacca   2040

cattgggagg aaccagtttc ctttcgtctg ccaggcccgc ctctggctcc tgggcctggg   2100

ctttagtctg ggctacggtt ccatgttcac caagatttgg tgggtccaca cggtcttcac   2160

aaagaaggaa gaaaagaagg agtggaggaa gactctggaa ccctggaagc tgtatgccac   2220

agtgggcctg ctggtgggca tggatgtcct cactctcgcc atctggcaga tcgtggaccc   2280

tctgcaccgg accattgaga catttgccaa ggaggaacct aaggaagata ttgacgtctc   2340

tattctgccc cagctggagc attgcagctc caggaagatg aatacatggc ttggcatttt   2400

ctatggttac aaggggctgc tgctgctgct gggaatcttc cttgcttatg agaccaagag   2460

tgtgtccact gagaagatca atgatcaccg ggctgtgggc atggctatct acaatgtggc   2520

agtcctgtgc ctcatcactg ctcctgtcac catgattctg tccagccagc aggatgcagc   2580

ctttgccttt gcctctcttg ccatagtttt ctcctcctat atcactcttg ttgtgctctt   2640

tgtgcccaag atgcgcaggc tgatcacccg aggggaatgg cagtcggagg cgcaggacac   2700

catgaagaca gggtcatcga ccaacaacaa cgaggaggag aagtcccggc tgttggagaa   2760

ggagaaccgt gaactggaaa agatcattgc tgagaaagag gagcgtgtct ctgaactgcg   2820

ccatcaactc cagtctcggc agcagctccg ctcccggcgc cacccaccga cacccccaga   2880

accctctggg ggcctgccca ggggaccccc tgagcccccc gaccggctta gctgtgatgg   2940

gagtcgagtg catttgcttt ataagtgagg gtagggtgag ggaggacagg ccagtagggg   3000

gagggaaagg gagaggggaa gggcagggga ctcaggaagc agggggtccc catccccagc   3060

tgggaagaac atgctatcca atctcatctc ttgtaaatac atgtccccct gtgagttctg   3120

ggctgatttg ggtctctcat acctctggga aacagacctt tttctctctt actgcttcat   3180

gtaattttgt atcacctctt cacaatttag ttcgtacctg gcttgaagct gctcactgct   3240

cacacgctgc ctcctcagca gcctcactgc atctttctct tcccatgcaa caccctcttc   3300

tagttaccac ggcaacccct gcagctcctc tgcctttgtg ctctgttcct gtccagcagg   3360

ggtctcccaa caagtgctct ttccacccca aaggggcctc tccttttctc cactgtcata   3420

atctctttcc atcttacttg cccttctata ctttctcaca tgtggctccc cctgaatttt   3480

gcttcctttg ggagctcatt cttttcgcca aggctcacat gctccttgcc tctgctctgt   3540

gcactcacgc tcagcacaca tgcatcctcc cctctcctgc gtgtgcccac tgaacatgct   3600

catgtgtaca cacgcttttc ccgtatgctt tcttcatgtt cagtcacatg tgctctcggg   3660

tgccctgcat tcacagctac gtgtgcccct ctcatggtca tgggtctgcc cttgagcgtg   3720

tttgggtagg catgtgcaat ttgtctagca tgctgagtca tgtctttcct atttgcacac   3780

gtccatgttt atccatgtac tttccctgtg taccctccat gtaccttgtg tactttcttc   3840

ccttaaatca tggtattctt ctgacagagc catatgtacc ctaccctgca cattgttatg   3900

cacttttccc caattcatgt ttggtggggc catccacacc ctctccttgt cacagaatct   3960

ccatttctgc tcagattccc cccatctcca ttgcattcat gtactaccct cagtctacac   4020

tcacaatcat cttctcccaa gactgctccc ttttgttttg tgtttttttg aggggaatta   4080

aggaaaaata agtgggggca ggtttggaga gctgcttcca gtggatagtt gatgagaatc   4140

ctgaccaaag gaaggcaccc ttgactgttg ggatagacag atggacctat ggggtgggag   4200

gtggtgtccc tttcacactg tggtgtctct tggggaagga tctccccgaa tctcaataaa   4260

ccagtgaaca gtgtgactcg gcaaaaaaaa aaaa                               4294


<210>  336
<211>  578
<212>  PRT
<213>  Homo sapiens

<400>  336

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
1               5                   10                  15


Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
            20                  25                  30


Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
        35                  40                  45


Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
    50                  55                  60


Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
65                  70                  75                  80


Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                85                  90                  95


Val Arg Ile Cys Ser Lys Ser Tyr Leu Thr Leu Glu Asn Gly Lys Val 
            100                 105                 110


Phe Leu Thr Gly Gly Asp Leu Pro Ala Leu Asp Gly Ala Arg Val Asp 
        115                 120                 125


Phe Arg Cys Asp Pro Asp Phe His Leu Val Gly Ser Ser Arg Ser Ile 
    130                 135                 140


Cys Ser Gln Gly Gln Trp Ser Thr Pro Lys Pro His Cys Gln Val Asn 
145                 150                 155                 160


Arg Thr Pro His Ser Glu Arg Arg Ala Val Tyr Ile Gly Ala Leu Phe 
                165                 170                 175


Pro Met Ser Gly Gly Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val 
            180                 185                 190


Glu Met Ala Leu Glu Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp 
        195                 200                 205


Tyr Glu Leu Lys Leu Ile His His Asp Ser Lys Cys Asp Pro Gly Gln 
    210                 215                 220


Ala Thr Lys Tyr Leu Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile 
225                 230                 235                 240


Ile Leu Met Pro Gly Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala 
                245                 250                 255


Ala Arg Met Trp Asn Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro 
            260                 265                 270


Ala Leu Ser Asn Arg Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro 
        275                 280                 285


Ser Ala Thr Leu His Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp 
    290                 295                 300


Gly Trp Lys Lys Ile Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr 
305                 310                 315                 320


Ser Thr Leu Asp Asp Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu 
                325                 330                 335


Ile Thr Phe Arg Gln Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys 
            340                 345                 350


Asn Leu Lys Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu 
        355                 360                 365


Thr Glu Ala Arg Lys Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe 
    370                 375                 380


Gly Lys Lys Tyr Val Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp 
385                 390                 395                 400


Phe Lys Ile Tyr Asp Pro Ser Ile Asn Cys Thr Val Asp Glu Met Thr 
                405                 410                 415


Glu Ala Val Glu Gly His Ile Thr Thr Glu Ile Val Met Leu Asn Pro 
            420                 425                 430


Ala Asn Thr Arg Ser Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu 
        435                 440                 445


Lys Leu Thr Lys Arg Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe 
    450                 455                 460


Gln Glu Ala Pro Leu Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala 
465                 470                 475                 480


Leu Asn Lys Thr Ser Gly Gly Gly Ser Arg Ser Gly Val Arg Leu Glu 
                485                 490                 495


Asp Phe Asn Tyr Asn Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala 
            500                 505                 510


Met Asn Ser Ser Ser Phe Glu Gly Val Ser Gly His Val Val Phe Asp 
        515                 520                 525


Ala Ser Gly Ser Arg Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly 
    530                 535                 540


Gly Ser Tyr Lys Lys Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu 
545                 550                 555                 560


Ser Trp Ser Lys Thr Asp Lys Trp Ile Val Ile Ser Arg Thr His Ser 
                565                 570                 575


Pro Thr 



<210>  337
<211>  2050
<212>  DNA
<213>  Homo sapiens

<400>  337
gtggggctgt ttctgcgggc acagctgcag caattaccgg agtggaggca gggcccaggc     60

agcactgccc tccaagatct tcccttgggc ttttcagcag taaggggaca tgcaccccaa    120

gggcctccac ttggcctgac cttgctgcgg gggctctctg tccccaggaa cagtagagat    180

ggcaagctta tcaagaccct ctctgcccag ctgcctctgc tccttcctcc tcctcctcct    240

cctccaagtg tcttccagct atgcagggca gttcagagtg ataggaccaa gacaccctat    300

ccgggctctg gtcggggatg aagtggaatt gccatgtcgc atatctcctg ggaagaacgc    360

tacaggcatg gaggtggggt ggtaccgccc ccccttctct agggtggttc atctctacag    420

aaatggcaag gaccaagatg gagaccaggc acctgaatat cggggccgga cagagctgct    480

gaaagatgct attggtgagg gaaaggtgac tctcaggatc cggaatgtaa ggttctcaga    540

tgaaggaggt ttcacctgct tcttccgaga tcattcttac caagaggagg cagcaatgga    600

attgaaagta gaagatcctt tctactgggt gagccctgga gtgctggttc tcctcgcggt    660

gctgcctgtg ctcctcctgc agatcactgt tggcctcatc ttcctctgcc tgcagtacag    720

actgagagga aaacttcgag cagagataga gaatctccac cggacttttg agtcctttgg    780

tgttctagga ccccaggtta aggaaccaaa aaagacaggg caattccttg aagagctacg    840

aaatcccttc tgagtgatgt cacatcttgg caggggtgga ggagagcctg gttgcccagg    900

gatttgtcct tggggacatc tcatccatca agttgcacac tcactggcat ctttgctatg    960

gggacattcc aatttgcact ttcaggaaca ctctgaattc caagtagaat tgatttccct   1020

tcttctgtca tctacctttt ctcttcattt tcccattttt attacccttc tttccatttc   1080

tctctccagt cttccacctg gaagccctct ctggctaagg acaggcaggt gcccctctct   1140

ccatcagagg acacctgtac tggagagcaa cacaggatgg tctctgccat gaactggagg   1200

ccaggaatct cctcactgaa aattacagta tggtaacttt gcaaatggtg gttgtttctt   1260

ccaagactcc agccctgatt gcgcaaaact gaaaggcatg tgaagggaag gaagaggaag   1320

agtgcaaaac attgaagaga gagctgagtg agctgaagag tgaggatatg agtagcccca   1380

acccaaacct ggagatgggg agaaacctac agaatactag ccagagctcc tccttgtctt   1440

ggcagcctac tagggacctg gggaagcaaa aacgaaagct gggcaacatg cctgctttag   1500

aatgttttcc ttctacttac acatcttcca caggtctcag aatctttcct tcctctcatc   1560

cttttctcct atcttcatat ctatcagagt atccactgtt tattcaacaa ctactacttg   1620

atggtcagac acaaacaaac aagctaggtg ctaattaata aagatacgag ttttggccgg   1680

gtgcggtggc tcacgcctgt aatcccagca ctttgggagg ccgaggcggg cgaatcacga   1740

ggtcaggagt tcaagaccag cctggccaac atggtgaaac cccatctcta ctaaaaatac   1800

aaacaattaa ctgagcatag tggtgggcac ctataatacc agctactccg gaggctgagg   1860

caggagaatc gcttgaaccc aggaggcaga ggttgcagtg agctgagatc gtgccactgc   1920

actctagccg gagtgacaga gtaagactct gtctcaaaaa taaataaata aataaataaa   1980

taaataaata aataaataaa taaaaaataa taatacaagt tttcataagc acacttctaa   2040

aaaaaaaaaa                                                          2050


<210>  338
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  338

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190


Leu His Arg Thr Phe Glu Ser Phe Gly Val Leu Gly Pro Gln Val Lys 
        195                 200                 205


Glu Pro Lys Lys Thr Gly Gln Phe Leu Glu Glu Leu Arg Asn Pro Phe 
    210                 215                 220


<210>  339
<211>  1731
<212>  DNA
<213>  Homo sapiens

<400>  339
gtggggctgt ttctgcgggc acagctgcag caattaccgg agtggaggca gggcccaggc     60

agcactgccc tccaagatct tcccttgggc ttttcagcag taaggggaca tgcaccccaa    120

gggcctccac ttggcctgac cttgctgcgg gggctctctg tccccaggaa cagtagagat    180

ggcaagctta tcaagaccct ctctgcccag ctgcctctgc tccttcctcc tcctcctcct    240

cctccaagtg tcttccagct atgcagggca gttcagagtg ataggaccaa gacaccctat    300

ccgggctctg gtcggggatg aagtggaatt gccatgtcgc atatctcctg ggaagaacgc    360

tacaggcatg gaggtggggt ggtaccgccc ccccttctct agggtggttc atctctacag    420

aaatggcaag gaccaagatg gagaccaggc acctgaatat cggggccgga cagagctgct    480

gaaagatgct attggtgagg gaaaggtgac tctcaggatc cggaatgtaa ggttctcaga    540

tgaaggaggt ttcacctgct tcttccgaga tcattcttac caagaggagg cagcaatgga    600

attgaaagta gaagatcctt tctactgggt gagccctgga gtgctggttc tcctcgcggt    660

gctgcctgtg ctcctcctgc agatcactgt tggcctcatc ttcctctgcc tgcagtacag    720

actgagagga aaacttcgag cagagataga gaatctccac cggacttttg tcttccacct    780

ggaagccctc tctggctaag gacaggcagg tgcccctctc tccatcagag gacacctgta    840

ctggagagca acacaggatg gtctctgcca tgaactggag gccaggaatc tcctcactga    900

aaattacagt atggtaactt tgcaaatggt ggttgtttct tccaagactc cagccctgat    960

tgcgcaaaac tgaaaggcat gtgaagggaa ggaagaggaa gagtgcaaaa cattgaagag   1020

agagctgagt gagctgaaga gtgaggatat gagtagcccc aacccaaacc tggagatggg   1080

gagaaaccta cagaatacta gccagagctc ctccttgtct tggcagccta ctagggacct   1140

ggggaagcaa aaacgaaagc tgggcaacat gcctgcttta gaatgttttc cttctactta   1200

cacatcttcc acaggtctca gaatctttcc ttcctctcat ccttttctcc tatcttcata   1260

tctatcagag tatccactgt ttattcaaca actactactt gatggtcaga cacaaacaaa   1320

caagctaggt gctaattaat aaagatacga gttttggccg ggtgcggtgg ctcacgcctg   1380

taatcccagc actttgggag gccgaggcgg gcgaatcacg aggtcaggag ttcaagacca   1440

gcctggccaa catggtgaaa ccccatctct actaaaaata caaacaatta actgagcata   1500

gtggtgggca cctataatac cagctactcc ggaggctgag gcaggagaat cgcttgaacc   1560

caggaggcag aggttgcagt gagctgagat cgtgccactg cactctagcc ggagtgacag   1620

agtaagactc tgtctcaaaa ataaataaat aaataaataa ataaataaat aaataaataa   1680

ataaaaaata ataatacaag ttttcataag cacacttcta aaaaaaaaaa a            1731


<210>  340
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  340

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190


Leu His Arg Thr Phe Val Phe His Leu Glu Ala Leu Ser Gly 
        195                 200                 205


<210>  341
<211>  1869
<212>  DNA
<213>  Homo sapiens

<400>  341
gtggggctgt ttctgcgggc acagctgcag caattaccgg agtggaggca gggcccaggc     60

agcactgccc tccaagatct tcccttgggc ttttcagcag taaggggaca tgcaccccaa    120

gggcctccac ttggcctgac cttgctgcgg gggctctctg tccccaggaa cagtagagat    180

ggcaagctta tcaagaccct ctctgcccag ctgcctctgc tccttcctcc tcctcctcct    240

cctccaagtg tcttccagct atgcagggca gttcagagtg ataggaccaa gacaccctat    300

ccgggctctg gtcggggatg aagtggaatt gccatgtcgc atatctcctg ggaagaacgc    360

tacaggcatg gaggtggggt ggtaccgccc ccccttctct agggtggttc atctctacag    420

aaatggcaag gaccaagatg gagaccaggc acctgaatat cggggccgga cagagctgct    480

gaaagatgct attggtgagg gaaaggtgac tctcaggatc cggaatgtaa ggttctcaga    540

tgaaggaggt ttcacctgct tcttccgaga tcattcttac caagaggagg cagcaatgga    600

attgaaagta gaagatcctt tctactgggt gagccctgga gtgctggttc tcctcgcggt    660

gctgcctgtg ctcctcctgc agatcactgt tggcctcatc ttcctctgcc tgcagtacag    720

actgagagga aaacttcgag cagagataga gaatctccac cggacttttg atccccactt    780

tctgagggtg ccctgctgga agataaccct gtttgtaatt gtgccggttc ttggaccctt    840

ggttgccttg atcatctgct acaactggct acatcgaaga ctagcagggc aattccttga    900

agagctactc ttccacctgg aagccctctc tggctaagga caggcaggtg cccctctctc    960

catcagagga cacctgtact ggagagcaac acaggatggt ctctgccatg aactggaggc   1020

caggaatctc ctcactgaaa attacagtat ggtaactttg caaatggtgg ttgtttcttc   1080

caagactcca gccctgattg cgcaaaactg aaaggcatgt gaagggaagg aagaggaaga   1140

gtgcaaaaca ttgaagagag agctgagtga gctgaagagt gaggatatga gtagccccaa   1200

cccaaacctg gagatgggga gaaacctaca gaatactagc cagagctcct ccttgtcttg   1260

gcagcctact agggacctgg ggaagcaaaa acgaaagctg ggcaacatgc ctgctttaga   1320

atgttttcct tctacttaca catcttccac aggtctcaga atctttcctt cctctcatcc   1380

ttttctccta tcttcatatc tatcagagta tccactgttt attcaacaac tactacttga   1440

tggtcagaca caaacaaaca agctaggtgc taattaataa agatacgagt tttggccggg   1500

tgcggtggct cacgcctgta atcccagcac tttgggaggc cgaggcgggc gaatcacgag   1560

gtcaggagtt caagaccagc ctggccaaca tggtgaaacc ccatctctac taaaaataca   1620

aacaattaac tgagcatagt ggtgggcacc tataatacca gctactccgg aggctgaggc   1680

aggagaatcg cttgaaccca ggaggcagag gttgcagtga gctgagatcg tgccactgca   1740

ctctagccgg agtgacagag taagactctg tctcaaaaat aaataaataa ataaataaat   1800

aaataaataa ataaataaat aaaaaataat aatacaagtt ttcataagca cacttctaaa   1860

aaaaaaaaa                                                           1869


<210>  342
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  342

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190


Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys 
        195                 200                 205


Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu 
    210                 215                 220


Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu 
225                 230                 235                 240


Glu Glu Leu Leu Phe His Leu Glu Ala Leu Ser Gly 
                245                 250


<210>  343
<211>  2119
<212>  DNA
<213>  Homo sapiens

<400>  343
gtggggctgt ttctgcgggc acagctgcag caattaccgg agtggaggca gggcccaggc     60

agcactgccc tccaagatct tcccttgggc ttttcagcag taaggggaca tgcaccccaa    120

gggcctccac ttggcctgac cttgctgcgg gggctctctg tccccaggaa cagtagagat    180

ggcaagctta tcaagaccct ctctgcccag ctgcctctgc tccttcctcc tcctcctcct    240

cctccaagtg tcttccagct atgcagggca gttcagagtg ataggaccaa gacaccctat    300

ccgggctctg gtcggggatg aagtggaatt gccatgtcgc atatctcctg ggaagaacgc    360

tacaggcatg gaggtggggt ggtaccgccc ccccttctct agggtggttc atctctacag    420

aaatggcaag gaccaagatg gagaccaggc acctgaatat cggggccgga cagagctgct    480

gaaagatgct attggtgagg gaaaggtgac tctcaggatc cggaatgtaa ggttctcaga    540

tgaaggaggt ttcacctgct tcttccgaga tcattcttac caagaggagg cagcaatgga    600

attgaaagta gaagatcctt tctactgggt gagccctgga gtgctggttc tcctcgcggt    660

gctgcctgtg ctcctcctgc agatcactgt tggcctcatc ttcctctgcc tgcagtacag    720

actgagagga aaacttcgag cagagataga gaatctccac cggacttttg atccccactt    780

tctgagggtg ccctgctgga agataaccct gtttgtaatt gtgccggttc ttggaccctt    840

ggttgccttg atcatctgct acaactggct acatcgaaga ctagcagggc aattccttga    900

agagctacga aatcccttct gagtgatgtc acatcttggc aggggtggag gagagcctgg    960

ttgcccaggg atttgtcctt ggggacatct catccatcaa gttgcacact cactggcatc   1020

tttgctatgg ggacattcca atttgcactt tcaggaacac tctgaattcc aagtagaatt   1080

gatttccctt cttctgtcat ctaccttttc tcttcatttt cccattttta ttacccttct   1140

ttccatttct ctctccagtc ttccacctgg aagccctctc tggctaagga caggcaggtg   1200

cccctctctc catcagagga cacctgtact ggagagcaac acaggatggt ctctgccatg   1260

aactggaggc caggaatctc ctcactgaaa attacagtat ggtaactttg caaatggtgg   1320

ttgtttcttc caagactcca gccctgattg cgcaaaactg aaaggcatgt gaagggaagg   1380

aagaggaaga gtgcaaaaca ttgaagagag agctgagtga gctgaagagt gaggatatga   1440

gtagccccaa cccaaacctg gagatgggga gaaacctaca gaatactagc cagagctcct   1500

ccttgtcttg gcagcctact agggacctgg ggaagcaaaa acgaaagctg ggcaacatgc   1560

ctgctttaga atgttttcct tctacttaca catcttccac aggtctcaga atctttcctt   1620

cctctcatcc ttttctccta tcttcatatc tatcagagta tccactgttt attcaacaac   1680

tactacttga tggtcagaca caaacaaaca agctaggtgc taattaataa agatacgagt   1740

tttggccggg tgcggtggct cacgcctgta atcccagcac tttgggaggc cgaggcgggc   1800

gaatcacgag gtcaggagtt caagaccagc ctggccaaca tggtgaaacc ccatctctac   1860

taaaaataca aacaattaac tgagcatagt ggtgggcacc tataatacca gctactccgg   1920

aggctgaggc aggagaatcg cttgaaccca ggaggcagag gttgcagtga gctgagatcg   1980

tgccactgca ctctagccgg agtgacagag taagactctg tctcaaaaat aaataaataa   2040

ataaataaat aaataaataa ataaataaat aaaaaataat aatacaagtt ttcataagca   2100

cacttctaaa aaaaaaaaa                                                2119


<210>  344
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  344

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190


Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys 
        195                 200                 205


Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu 
    210                 215                 220


Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu 
225                 230                 235                 240


Glu Glu Leu Arg Asn Pro Phe 
                245


<210>  345
<211>  1752
<212>  DNA
<213>  Homo sapiens

<400>  345
gtggggctgt ttctgcgggc acagctgcag caattaccgg agtggaggca gggcccaggc     60

agcactgccc tccaagatct tcccttgggc ttttcagcag taaggggaca tgcaccccaa    120

gggcctccac ttggcctgac cttgctgcgg gggctctctg tccccaggaa cagtagagat    180

ggcaagctta tcaagaccct ctctgcccag ctgcctctgc tccttcctcc tcctcctcct    240

cctccaagtg tcttccagct atgcagggca gttcagagtg ataggaccaa gacaccctat    300

ccgggctctg gtcggggatg aagtggaatt gccatgtcgc atatctcctg ggaagaacgc    360

tacaggcatg gaggtggggt ggtaccgccc ccccttctct agggtggttc atctctacag    420

aaatggcaag gaccaagatg gagaccaggc acctgaatat cggggccgga cagagctgct    480

gaaagatgct attggtgagg gaaaggtgac tctcaggatc cggaatgtaa ggttctcaga    540

tgaaggaggt ttcacctgct tcttccgaga tcattcttac caagaggagg cagcaatgga    600

attgaaagta gaagatcctt tctactgggt gagccctgga gtgctggttc tcctcgcggt    660

gctgcctgtg ctcctcctgc agatcactgt tggcctcatc ttcctctgcc tgcagtacag    720

actgagagga aaacttcgag cagagataga gaatctccac cggacttttg ggcaattcct    780

tgaagagcta ctcttccacc tggaagccct ctctggctaa ggacaggcag gtgcccctct    840

ctccatcaga ggacacctgt actggagagc aacacaggat ggtctctgcc atgaactgga    900

ggccaggaat ctcctcactg aaaattacag tatggtaact ttgcaaatgg tggttgtttc    960

ttccaagact ccagccctga ttgcgcaaaa ctgaaaggca tgtgaaggga aggaagagga   1020

agagtgcaaa acattgaaga gagagctgag tgagctgaag agtgaggata tgagtagccc   1080

caacccaaac ctggagatgg ggagaaacct acagaatact agccagagct cctccttgtc   1140

ttggcagcct actagggacc tggggaagca aaaacgaaag ctgggcaaca tgcctgcttt   1200

agaatgtttt ccttctactt acacatcttc cacaggtctc agaatctttc cttcctctca   1260

tccttttctc ctatcttcat atctatcaga gtatccactg tttattcaac aactactact   1320

tgatggtcag acacaaacaa acaagctagg tgctaattaa taaagatacg agttttggcc   1380

gggtgcggtg gctcacgcct gtaatcccag cactttggga ggccgaggcg ggcgaatcac   1440

gaggtcagga gttcaagacc agcctggcca acatggtgaa accccatctc tactaaaaat   1500

acaaacaatt aactgagcat agtggtgggc acctataata ccagctactc cggaggctga   1560

ggcaggagaa tcgcttgaac ccaggaggca gaggttgcag tgagctgaga tcgtgccact   1620

gcactctagc cggagtgaca gagtaagact ctgtctcaaa aataaataaa taaataaata   1680

aataaataaa taaataaata aataaaaaat aataatacaa gttttcataa gcacacttct   1740

aaaaaaaaaa aa                                                       1752


<210>  346
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  346

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190


Leu His Arg Thr Phe Gly Gln Phe Leu Glu Glu Leu Leu Phe His Leu 
        195                 200                 205


Glu Ala Leu Ser Gly 
    210


<210>  347
<211>  1800
<212>  DNA
<213>  Homo sapiens

<400>  347
gtggggctgt ttctgcgggc acagctgcag caattaccgg agtggaggca gggcccaggc     60

agcactgccc tccaagatct tcccttgggc ttttcagcag taaggggaca tgcaccccaa    120

gggcctccac ttggcctgac cttgctgcgg gggctctctg tccccaggaa cagtagagat    180

ggcaagctta tcaagaccct ctctgcccag ctgcctctgc tccttcctcc tcctcctcct    240

cctccaagtg tcttccagct atgcagggca gttcagagtg ataggaccaa gacaccctat    300

ccgggctctg gtcggggatg aagtggaatt gccatgtcgc atatctcctg ggaagaacgc    360

tacaggcatg gaggtggggt ggtaccgccc ccccttctct agggtggttc atctctacag    420

aaatggcaag gaccaagatg gagaccaggc acctgaatat cggggccgga cagagctgct    480

gaaagatgct attggtgagg gaaaggtgac tctcaggatc cggaatgtaa ggttctcaga    540

tgaaggaggt ttcacctgct tcttccgaga tcattcttac caagaggagg cagcaatgga    600

attgaaagta gaagatcctt tctactgggt gagccctgga gtgctggttc tcctcgcggt    660

gctgcctgtg ctcctcctgc agatcactgt tggcctcatc ttcctctgcc tgcagtacag    720

actgagagga aaacttcgag cagagataga gaatctccac cggacttttg agtcctttgg    780

tgttctagga ccccaggtta aggaaccaaa aaagacaggg caattccttg aagagctact    840

cttccacctg gaagccctct ctggctaagg acaggcaggt gcccctctct ccatcagagg    900

acacctgtac tggagagcaa cacaggatgg tctctgccat gaactggagg ccaggaatct    960

cctcactgaa aattacagta tggtaacttt gcaaatggtg gttgtttctt ccaagactcc   1020

agccctgatt gcgcaaaact gaaaggcatg tgaagggaag gaagaggaag agtgcaaaac   1080

attgaagaga gagctgagtg agctgaagag tgaggatatg agtagcccca acccaaacct   1140

ggagatgggg agaaacctac agaatactag ccagagctcc tccttgtctt ggcagcctac   1200

tagggacctg gggaagcaaa aacgaaagct gggcaacatg cctgctttag aatgttttcc   1260

ttctacttac acatcttcca caggtctcag aatctttcct tcctctcatc cttttctcct   1320

atcttcatat ctatcagagt atccactgtt tattcaacaa ctactacttg atggtcagac   1380

acaaacaaac aagctaggtg ctaattaata aagatacgag ttttggccgg gtgcggtggc   1440

tcacgcctgt aatcccagca ctttgggagg ccgaggcggg cgaatcacga ggtcaggagt   1500

tcaagaccag cctggccaac atggtgaaac cccatctcta ctaaaaatac aaacaattaa   1560

ctgagcatag tggtgggcac ctataatacc agctactccg gaggctgagg caggagaatc   1620

gcttgaaccc aggaggcaga ggttgcagtg agctgagatc gtgccactgc actctagccg   1680

gagtgacaga gtaagactct gtctcaaaaa taaataaata aataaataaa taaataaata   1740

aataaataaa taaaaaataa taatacaagt tttcataagc acacttctaa aaaaaaaaaa   1800


<210>  348
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  348

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190


Leu His Arg Thr Phe Glu Ser Phe Gly Val Leu Gly Pro Gln Val Lys 
        195                 200                 205


Glu Pro Lys Lys Thr Gly Gln Phe Leu Glu Glu Leu Leu Phe His Leu 
    210                 215                 220


Glu Ala Leu Ser Gly 
225


<210>  349
<211>  2002
<212>  DNA
<213>  Homo sapiens

<400>  349
gtggggctgt ttctgcgggc acagctgcag caattaccgg agtggaggca gggcccaggc     60

agcactgccc tccaagatct tcccttgggc ttttcagcag taaggggaca tgcaccccaa    120

gggcctccac ttggcctgac cttgctgcgg gggctctctg tccccaggaa cagtagagat    180

ggcaagctta tcaagaccct ctctgcccag ctgcctctgc tccttcctcc tcctcctcct    240

cctccaagtg tcttccagct atgcagggca gttcagagtg ataggaccaa gacaccctat    300

ccgggctctg gtcggggatg aagtggaatt gccatgtcgc atatctcctg ggaagaacgc    360

tacaggcatg gaggtggggt ggtaccgccc ccccttctct agggtggttc atctctacag    420

aaatggcaag gaccaagatg gagaccaggc acctgaatat cggggccgga cagagctgct    480

gaaagatgct attggtgagg gaaaggtgac tctcaggatc cggaatgtaa ggttctcaga    540

tgaaggaggt ttcacctgct tcttccgaga tcattcttac caagaggagg cagcaatgga    600

attgaaagta gaagatcctt tctactgggt gagccctgga gtgctggttc tcctcgcggt    660

gctgcctgtg ctcctcctgc agatcactgt tggcctcatc ttcctctgcc tgcagtacag    720

actgagagga aaacttcgag cagagataga gaatctccac cggacttttg ggcaattcct    780

tgaagagcta cgaaatccct tctgagtgat gtcacatctt ggcaggggtg gaggagagcc    840

tggttgccca gggatttgtc cttggggaca tctcatccat caagttgcac actcactggc    900

atctttgcta tggggacatt ccaatttgca ctttcaggaa cactctgaat tccaagtaga    960

attgatttcc cttcttctgt catctacctt ttctcttcat tttcccattt ttattaccct   1020

tctttccatt tctctctcca gtcttccacc tggaagccct ctctggctaa ggacaggcag   1080

gtgcccctct ctccatcaga ggacacctgt actggagagc aacacaggat ggtctctgcc   1140

atgaactgga ggccaggaat ctcctcactg aaaattacag tatggtaact ttgcaaatgg   1200

tggttgtttc ttccaagact ccagccctga ttgcgcaaaa ctgaaaggca tgtgaaggga   1260

aggaagagga agagtgcaaa acattgaaga gagagctgag tgagctgaag agtgaggata   1320

tgagtagccc caacccaaac ctggagatgg ggagaaacct acagaatact agccagagct   1380

cctccttgtc ttggcagcct actagggacc tggggaagca aaaacgaaag ctgggcaaca   1440

tgcctgcttt agaatgtttt ccttctactt acacatcttc cacaggtctc agaatctttc   1500

cttcctctca tccttttctc ctatcttcat atctatcaga gtatccactg tttattcaac   1560

aactactact tgatggtcag acacaaacaa acaagctagg tgctaattaa taaagatacg   1620

agttttggcc gggtgcggtg gctcacgcct gtaatcccag cactttggga ggccgaggcg   1680

ggcgaatcac gaggtcagga gttcaagacc agcctggcca acatggtgaa accccatctc   1740

tactaaaaat acaaacaatt aactgagcat agtggtgggc acctataata ccagctactc   1800

cggaggctga ggcaggagaa tcgcttgaac ccaggaggca gaggttgcag tgagctgaga   1860

tcgtgccact gcactctagc cggagtgaca gagtaagact ctgtctcaaa aataaataaa   1920

taaataaata aataaataaa taaataaata aataaaaaat aataatacaa gttttcataa   1980

gcacacttct aaaaaaaaaa aa                                            2002


<210>  350
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  350

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190


Leu His Arg Thr Phe Gly Gln Phe Leu Glu Glu Leu Arg Asn Pro Phe 
        195                 200                 205


<210>  351
<211>  2959
<212>  DNA
<213>  Homo sapiens

<400>  351
actacattgc ccagtaacct cctgggctcc gctgtgtttt tctattctgg ggtgtaaggg     60

gcagctggac cactccagct gggactgcta ggaaggttgc gggtccaccc ggccgagccg    120

aacgagggaa atggtcctca cccggccact cgccggttga aaaggggccg ccctggcagg    180

gaagcggccg ccgcggcgcg gtgcagcgca gcggcgagaa ggagtgcgtt atcgtcttgc    240

gctactgctg aatgtccgtc ccggaggagg aggagaggct tttgccgctg acccagagat    300

ggccccgagc gagcaaattc ctactgtccg gctgcgcggc taccgtggcc gagctagcaa    360

cctttcccct ggatctcaca aaaactcgac tccaaatgca aggagaagca gctcttgctc    420

ggttgggaga cggtgcaaga gaatctgccc cctatagggg aatggtgcgc acagccctag    480

ggatcattga agaggaaggc tttctaaagc tttggcaagg agtgacaccc gccatttaca    540

gacacgtagt gtattctgga ggtcgaatgg tcacatatga acatctccga gaggttgtgt    600

ttggcaaaag tgaagatgag cattatcccc tttggaaatc agtcattgga gggatgatgg    660

ctggtgttat tggccagttt ttagccaatc caactgacct agtgaaggtt cagatgcaaa    720

tggaaggaaa aaggaaactg gaaggaaaac cattgcgatt tcgtggtgta catcatgcat    780

ttgcaaaaat cttagctgaa ggaggaatac gagggctttg ggcaggctgg gtacccaata    840

tacaaagagc agcactggtg aatatgggag atttaaccac ttatgataca gtgaaacact    900

acttggtatt gaatacacca cttgaggaca atatcatgac tcacggttta tcaagtttat    960

gttctggact ggtagcttct attctgggaa caccagccga tgtcatcaaa agcagaataa   1020

tgaatcaacc acgagataaa caaggaaggg gacttttgta taaatcatcg actgactgct   1080

tgattcaggc tgttcaaggt gaaggattca tgagtctata taaaggcttt ttaccatctt   1140

ggctgagaat gaccccttgg tcaatggtgt tctggcttac ttatgaaaaa atcagagaga   1200

tgagtggagt cagtccattt taaaccccta aagatgcaac ccttaaagat acagtgttca   1260

gtattattga aatatgggca tctgcaacac atacccccta ttatttctac ctctttagga   1320

agacacctat tccacagaga ctgatttata gggggcagca ctttattttt ttctggaaac   1380

ccaagttctc tttgactcct ctttttgtcc aaaagtgatc tggtcggatc tcacaaggcc   1440

atccaatgag accccgcaca gcattttcta aagaagaatc gaagcctgac cactttcacc   1500

ttgggcaaga aggtttggcc tttgagttgc tattctatgc tgaagagcct gcttagagga   1560

ggagtaccag gagggagcca gcatttcaga tctgaagtag acgataggaa tgtggaagaa   1620

cacatacata gtgcttaaga aatacattta acctgttatg tcagtattta tcaatgaagt   1680

ttgataattc acttttctgt cattgttaaa gcgtacatac tgtaaattaa agggaggtga   1740

atggaaatta atgaataaac attttgagtt tccctagtgt tgaaggaagg tgtacttttt   1800

cttgtcagaa agataaaaaa aatcaagttg agatgatgtt tgaatttcaa gaaaagaggc   1860

tgctttctgt cagtgccctc tcattagatc tgtgttaatt agttagcact ccactgcaca   1920

tgctaatgac ttcctctgac agccacacac cgaatcttga tgaaaaaaga gaagagcatt   1980

tgccttgtta catagtctgt tacaagccag atatgttgct agctctcaag agttgtaata   2040

tattaagaac tacaacttat ttgattaaaa ctcagctgta tagatccttt tataaagcac   2100

cttttgttaa acatcagcct ttcattggta ttttaaaagc aaggcagata gatatgaagt   2160

cagccaactc tgacatgcgt cctttcttat ctcccttacc tgacactagg ggctctagag   2220

aggcagagag agcactcaca aatcacacta aaactgccag cggcctgact cttactcagt   2280

ttagcaaaaa ttcttgccta aaaagtgata agtaaaaatc tgtttatggt atacagttat   2340

gtctcgaatc tttgaatcaa atccatgttc ttattttaga aaggtaagag ttcttcaaat   2400

tcagctacat accaccggct ctcccaacct cagacggtgg gcatttctgg atggatggct   2460

gcggttatgg ataaaggctg taactgttaa cacagaaaaa catgaaaagc tcaggcccaa   2520

gaaaggcctt ggagccagcc aaacagaatt tgttctaatg gacatggatg atgttgaaca   2580

gaaaaaagtt tacaagtgct ttgtggttgc actaatgtat actcactgcc attttaagag   2640

ggggaagtac attttaaaat atatttgaat gtcatgtact gatatgcagt agcttattgt   2700

ttttctagtt gcagagaatg tgaagtttaa tctcttaaaa tatttagatg gtctactttt   2760

tcattgaatt tgtcaatatg taattgcgtt gtaaaatatt atatatatat atatatatat   2820

atatatatat atatgcttaa cttcccaagt gttctgcatt gaaccactta gggaaaattt   2880

tgtttgtttt tatgttttgt aatttttaaa attaagtaaa gactggatca aaataattgc   2940

atccaacctg gaccgtgaa                                                2959


<210>  352
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  352

Met Ser Val Pro Glu Glu Glu Glu Arg Leu Leu Pro Leu Thr Gln Arg 
1               5                   10                  15


Trp Pro Arg Ala Ser Lys Phe Leu Leu Ser Gly Cys Ala Ala Thr Val 
            20                  25                  30


Ala Glu Leu Ala Thr Phe Pro Leu Asp Leu Thr Lys Thr Arg Leu Gln 
        35                  40                  45


Met Gln Gly Glu Ala Ala Leu Ala Arg Leu Gly Asp Gly Ala Arg Glu 
    50                  55                  60


Ser Ala Pro Tyr Arg Gly Met Val Arg Thr Ala Leu Gly Ile Ile Glu 
65                  70                  75                  80


Glu Glu Gly Phe Leu Lys Leu Trp Gln Gly Val Thr Pro Ala Ile Tyr 
                85                  90                  95


Arg His Val Val Tyr Ser Gly Gly Arg Met Val Thr Tyr Glu His Leu 
            100                 105                 110


Arg Glu Val Val Phe Gly Lys Ser Glu Asp Glu His Tyr Pro Leu Trp 
        115                 120                 125


Lys Ser Val Ile Gly Gly Met Met Ala Gly Val Ile Gly Gln Phe Leu 
    130                 135                 140


Ala Asn Pro Thr Asp Leu Val Lys Val Gln Met Gln Met Glu Gly Lys 
145                 150                 155                 160


Arg Lys Leu Glu Gly Lys Pro Leu Arg Phe Arg Gly Val His His Ala 
                165                 170                 175


Phe Ala Lys Ile Leu Ala Glu Gly Gly Ile Arg Gly Leu Trp Ala Gly 
            180                 185                 190


Trp Val Pro Asn Ile Gln Arg Ala Ala Leu Val Asn Met Gly Asp Leu 
        195                 200                 205


Thr Thr Tyr Asp Thr Val Lys His Tyr Leu Val Leu Asn Thr Pro Leu 
    210                 215                 220


Glu Asp Asn Ile Met Thr His Gly Leu Ser Ser Leu Cys Ser Gly Leu 
225                 230                 235                 240


Val Ala Ser Ile Leu Gly Thr Pro Ala Asp Val Ile Lys Ser Arg Ile 
                245                 250                 255


Met Asn Gln Pro Arg Asp Lys Gln Gly Arg Gly Leu Leu Tyr Lys Ser 
            260                 265                 270


Ser Thr Asp Cys Leu Ile Gln Ala Val Gln Gly Glu Gly Phe Met Ser 
        275                 280                 285


Leu Tyr Lys Gly Phe Leu Pro Ser Trp Leu Arg Met Thr Pro Trp Ser 
    290                 295                 300


Met Val Phe Trp Leu Thr Tyr Glu Lys Ile Arg Glu Met Ser Gly Val 
305                 310                 315                 320


Ser Pro Phe 



<210>  353
<211>  6817
<212>  DNA
<213>  Homo sapiens

<400>  353
atgtgctcga cgcccggaat gccggcgccg ggggcctcgc tggccctgcg ggtgtccttc     60

gtggacgtgc atcccgatgt gatcccggtg cagctgtggg ggctggtggg cgagcggcgg    120

ggcgagtacc tgcggctgag ccgggaaatc caggaagcgg cggccacgcg cggccagtgg    180

gcgctgggca gcgcctcggc ctcgcccggc gagctgtgcc tggtgcaggt cgggcttttg    240

tggcaccgct gccgcgtggt cagccggcag gcacaggaga gccgtgtctt cctgctggac    300

gagggccgca ccatcacggc cggagcaggc tcgctggcgc ctgggcgcag agagttcttc    360

aatttgccct cggaagtgct gggctgcgtg ctagcgggcc tggtgccggc aggctgcggc    420

gcgggctcag gcgagccgcc gcagcactgg cccgccgacg ccgtggactt ccttagcaac    480

cttcagggca aggaggtgca cgggtgcgtc ctggacgtgc tgctgctcca tcgcctggtc    540

ctcctggagg tgcctgatgt gttccaacag atgcgggagc tgggcctggc tcggcgggtg    600

cccgacagcc tcttccgttc gctgctggag cgctatctca cagcggccac tgctagcgtg    660

ggctccgggg tcccggttct ctcgcgagtc ccgctcaagc aaaagcagcc tggtctggat    720

tacttctatc cccagctgca gctgggcgtg acggaggccg tggtcataac ccaagtgtgc    780

catccccacc gcattcactg ccagctccgc agcgtctcgc aggagatcca ccgcctctcc    840

gagagcatgg cccaggtata ccggggttcc acggggacag gggatgagaa ctctaccagt    900

gccacctggg aggagaggga ggagagccca gataagccgg gctctccgtg tgcatcctgt    960

ggcctggatg gacattggta cagagcactg ttgcttgaga cttttcggcc ccagcgctgt   1020

gcccaggtgc ttcatgtgga ctatggaagg aaggagttag tgagttgcag cagccttcgg   1080

tacttgctgc ctgaatattt tcgaatgccg gtggtgacct acccttgtgc tttgtatgga   1140

ctctgggacg gtgggagagg ctggtctcgg tcacaggtcg gtgacctgaa gacactgata   1200

ctaggcaagg cagtgaatgc aaagattgaa ttttattgct cctttgagca tgtgtattat   1260

gtcagcctgt atggagaaga tgggattaat ctgaaccgtg tgtttggagt acagtcgtgt   1320

tgcttggctg accgagtcct tcagagccag gcaacagagg aggaggaacc agaaacatct   1380

cagtctcagt ctcctgctga agaagtagat gaagagattt cactcccagc cttaagatct   1440

atcaggttaa agatgaatgc cttctacgat gcgcaggtag agtttgttaa aaatccttct   1500

gagttttgga ttaggttgag gaaacacaat gtcaccttca gtaagctgat gaggagaatg   1560

tgtggtttct attcctctgc cagtaagctg gatggtgtag ttttgaaacc tgaacctgat   1620

gacctttgct gtgtcaagtg gaaagaaaat ggttattata gggccatagt caccaaattg   1680

gatgacaaga gtgtggatgt attcttagtt gaccgaggca attcggaaaa tgtggactgg   1740

tatgacgtaa ggatgctgct tcctcagttt aggcagctac caatattggc tgtgaagtgc   1800

accctggctg atatttggcc tttgggaaaa acttggagcc aggaggcagt ttcctttttt   1860

aaaaagactg tgctccacaa agaattagtc atccatattc ttgataaaca ggatcatcaa   1920

tatgttattg agattcttga cgaatcaaga acaggggaag aaaacattag taaggtaatt   1980

gcccaagctg gatatgccaa gtatcaggaa tttgaaacaa aggaaaatat cctggtaaat   2040

gcccactccc cagggcatgt ttcaaaccac tttactacgg agagtaacaa aatacctttt   2100

gccaagactg gagaaggaga gcagaaagcc aagagagaga ataaaaccac atctgtttca   2160

aaagctttga gtgacacaac agttgtaaca aatggttcaa ctgaactagt tgtgcaggaa   2220

aaagtgaaaa gagcatctgt ttattttcct cttatgcaga attgcttgga aattaagcca   2280

ggctcctcta gtaaaggaga gctggaagtt ggaagtacag tagaagtcag agtgtcttat   2340

gttgaaaacc ctggctattt ctggtgtcag ctgaccagga acatacaagg acttaaaact   2400

ctaatgtctg atattcagta ctattgcaaa aatacagctg ctcctcacca gagaaacacc   2460

cttgcttgtt tggctaagcg aacagtaaac agacagtggt ccagagcact tattagtggg   2520

atacagtctg tggagcatgt caatgtaaca tttgtagatt atggagacag agaaatggta   2580

tctgtgaaga atatttattc aattagtgaa gaatttctga aggttaaggc acaggctttt   2640

aggtgcagtc tttataattt aattcaacca gttggccaga atccctttgt ttgggatgta   2700

aaggcaatac aagctttcaa tgaatttata gataatgcat ggcaaaaaaa tctagaatta   2760

aaatgtacaa tatttgctct ggcttcaatt aatgaagaac tgtttaacat tgtggatttg   2820

ctaaccccct ttcagagtgc atgccatttc ttggtagaaa agagacttgc aagaccagta   2880

aaacttcaga agcctttgga gtcctctgtt cagctacatt cctacttcta ttctacacat   2940

gatatgaaaa ttggaagtga agaattagtt tatataacgc atattgatga cccttggaca   3000

ttttattgcc agctggcaag aaatgcaaat attttagaac agttgtcatg tagtattaca   3060

caattaagta aagttttgct gaatttaaaa acatctccct tgaaccctgg aaccttgtgc   3120

cttgccaagt atactgatgg aaactggtat aggggcatag taatagagaa agagccaaag   3180

aaagtcttct ttgttgattt tgggaatatt tatgtagtaa caagtgatga tctgcttcca   3240

atacctagtg atgcatatga tgtcttactt ttgcccatgc aagctgtcag atgttcatta   3300

tctgatattc ctgatcatat accagaagaa gtggtggtgt ggtttcagga gactatttta   3360

gataagtcat tgaaggcttt agttgtagca aaagatccag atggaacact gattatagaa   3420

ctatatggtg acaatattca aattagtgct agtattaata agaagttggg gctacttagt   3480

tacaaagata gaataagaaa aaaagaaagt gaagtcctct gttctacaac tgaaactctt   3540

gaagaaaaaa atgagaatat gaagttgcca tgtacagagt atttaagtaa atcagtaggg   3600

tacaagttac ctaataaaga aattttggaa gagtcatata aacctcagat caactcatca   3660

tacaaggaac tcaaactttt acaaagttta acaaaaacaa acttagtcac tcaatatcaa   3720

gactctgtgg gaaataaaaa tagtcaagtg tttccattaa caacagaaaa gaaagaagaa   3780

atttctgctg agacaccctt gaaaacagca agagtagaag ctactctttc agagagaaaa   3840

ataggagatt catgtgacaa agatttgcct ctgaaatttt gtgagttccc acagaagact   3900

ataatgcctg gatttaaaac aactgtatat gtttctcata taaatgacct ttcagacttt   3960

tatgttcaac taatagaaga tgaagctgaa attagtcatc tttcagagag attaaacagt   4020

gttaaaacaa ggcccgaata ttatgtaggt ccacctttgc aaagaggaga tatgatatgt   4080

gctgttttcc cagaagataa tttatggtat cgtgctgtga tcaaggagca acaacccaat   4140

gaccttctct ctgtgcagtt tatagattat ggcaatgttt ctgtggttca tactaacaaa   4200

ataggtaggc ttgaccttgt taatgcaata ttgccggggt tgtgcattca ttgctccttg   4260

cagggatttg aggttcctga caataaaaat tctaagaaaa tgatgcatta cttttcccaa   4320

cggaccagcg aggctgcaat aagatgtgaa tttgttaaat ttcaagacag atgggaagtt   4380

attcttgctg atgaacatgg gatcatagca gatgatatga ttagcaggta tgctctcagt   4440

gaaaaatctc aagtagaact ttctacccaa gtaattaaaa gtgccagttc aaagtctgtt   4500

aacaaatcag acattgacac ttcagtattt cttaactggt ataatccaga aaaaaaaatg   4560

ataagagctt atgccactgt gatagatgga cctgagtact tttggtgtca gtttgctgat   4620

acggagaaac ttcagtgttt agaagtagaa gtacagactg ctggagaaca ggtagcagac   4680

aggagaaatt gtatcccatg tccttatatt ggagatcctt gtatagtaag atacagagaa   4740

gatggacatt attatagggc acttatcact aatatttgtg aagattatct tgtatctgtc   4800

aggcttgtgg actttggaaa cattgaagac tgtgtggacc caaaagcact ctgggccatt   4860

ccttctgaac ttctgtcggt tcccatgcaa gcctttccat gttgcctctc agggtttaac   4920

atttcagaag gattatgttc tcaagaggga aatgactatt tctatgaaat aataacagaa   4980

gatgtgttgg aaataacaat actagaaatc agaagggatg tttgtgatat ccctttagca   5040

attgttgact tgaaaagcaa aggtaaaagt attaatgaga aaatggagaa atattctaag   5100

actggtatta aaagtgctct tccctatgaa aatattgact cagagataaa gcagactctt   5160

gggtcctaca atcttgatgt aggacttaag aaattaagta ataaagctgt acaaaataaa   5220

atatatatgg aacaacagac agatgagctt gctgaaataa ctgaaaaaga tgtaaacatt   5280

attggaacca aaccaagtaa cttccgtgac cctaaaactg ataacatttg tgaagggttt   5340

gaaaacccct gcaaagataa aattgatact gaggaactgg aaggtgaatt agagtgccat   5400

ctggttgaca aagcagagtt tgatgataaa tacctgatta caggatttaa cacattacta   5460

ccacatgcta atgaaacaaa ggagatacta gaactgaatt cacttgaggt gccgctttct   5520

cctgatgatg aatcaaaaga attcttagaa ctggaatcta ttgagttaca gaattctctg   5580

gtggtggatg aagaaaaagg ggagctaagc ccggtgccac cgaatgtgcc actctcccaa   5640

gagtgtgtca caaaaggcgc catggagcta tttacactgc agcttcctct cagctgtgaa   5700

gctgagaaac agccagaact agaactacct acagcccagc tgcctttaga tgacaagatg   5760

gatcctttgt ctttaggagt tagtcagaaa gcacaggaat ccatgtgtac tgaggacatg   5820

agaaagtcaa gttgtgtaga atcttttgat gaccagcgca ggatgtcatt gcatctacat   5880

ggagcagatt gtgatcctaa aacacagaat gaaatgaata tatgtgaaga agaatttgta   5940

gagtataaaa acagggatgc catttcggca ttgatgcctt tgttctctga ggaagaaagc   6000

agtgatggaa gcaagcacaa taatggttta ccagatcata tctcagctca actacagaac   6060

acctacactc tgaaagcctt tactgttgga tctaaatgtg ttgtgtggtc aagtctaaga   6120

aacacatggt ctaaatgtga gattttagaa acagctgaag aaggaacaag ggttttgaac   6180

ctttcaaatg gtatggagga gatagtgaac cctgagaatg tctggaatgg catacccaaa   6240

ttggataaga gtccacctga gaaaaggggt ttggaggtga tggagattta accgtggatc   6300

tatagctgtg gccaatcagt cagaagctgc ccttgaacaa gtggcatctt acgcagacca   6360

acagagtatt tgagaaaatt gaaaacatgt aaccacaaga agttgtcatt ttcaaaaact   6420

tctatatagg tggaaaacaa attaggtctc aggttgatgg tggggtgtgt ttatagtgat   6480

cctgttatat atacagatct gggatctttc gtctttattg tcttacgttt ctaattagtt   6540

gggaggattt attttgctaa acagtttact aacacattac atttcaaaaa ctattttggt   6600

acctttcaaa tacagtgttt aaattaaaat agaaaaataa gggctcatga caagtacatt   6660

atttgattct acttaggata gctttttagc aggatctcct tcagaatttt tgtcttgact   6720

ttgaatcttt gcctgtttgt ctaaacattt gactaacatt ctgtttgaat ttggaagtat   6780

tctaatacaa gatttgaata aagtttatcc ttaaata                            6817


<210>  354
<211>  2096
<212>  PRT
<213>  Homo sapiens

<400>  354

Met Cys Ser Thr Pro Gly Met Pro Ala Pro Gly Ala Ser Leu Ala Leu 
1               5                   10                  15


Arg Val Ser Phe Val Asp Val His Pro Asp Val Ile Pro Val Gln Leu 
            20                  25                  30


Trp Gly Leu Val Gly Glu Arg Arg Gly Glu Tyr Leu Arg Leu Ser Arg 
        35                  40                  45


Glu Ile Gln Glu Ala Ala Ala Thr Arg Gly Gln Trp Ala Leu Gly Ser 
    50                  55                  60


Ala Ser Ala Ser Pro Gly Glu Leu Cys Leu Val Gln Val Gly Leu Leu 
65                  70                  75                  80


Trp His Arg Cys Arg Val Val Ser Arg Gln Ala Gln Glu Ser Arg Val 
                85                  90                  95


Phe Leu Leu Asp Glu Gly Arg Thr Ile Thr Ala Gly Ala Gly Ser Leu 
            100                 105                 110


Ala Pro Gly Arg Arg Glu Phe Phe Asn Leu Pro Ser Glu Val Leu Gly 
        115                 120                 125


Cys Val Leu Ala Gly Leu Val Pro Ala Gly Cys Gly Ala Gly Ser Gly 
    130                 135                 140


Glu Pro Pro Gln His Trp Pro Ala Asp Ala Val Asp Phe Leu Ser Asn 
145                 150                 155                 160


Leu Gln Gly Lys Glu Val His Gly Cys Val Leu Asp Val Leu Leu Leu 
                165                 170                 175


His Arg Leu Val Leu Leu Glu Val Pro Asp Val Phe Gln Gln Met Arg 
            180                 185                 190


Glu Leu Gly Leu Ala Arg Arg Val Pro Asp Ser Leu Phe Arg Ser Leu 
        195                 200                 205


Leu Glu Arg Tyr Leu Thr Ala Ala Thr Ala Ser Val Gly Ser Gly Val 
    210                 215                 220


Pro Val Leu Ser Arg Val Pro Leu Lys Gln Lys Gln Pro Gly Leu Asp 
225                 230                 235                 240


Tyr Phe Tyr Pro Gln Leu Gln Leu Gly Val Thr Glu Ala Val Val Ile 
                245                 250                 255


Thr Gln Val Cys His Pro His Arg Ile His Cys Gln Leu Arg Ser Val 
            260                 265                 270


Ser Gln Glu Ile His Arg Leu Ser Glu Ser Met Ala Gln Val Tyr Arg 
        275                 280                 285


Gly Ser Thr Gly Thr Gly Asp Glu Asn Ser Thr Ser Ala Thr Trp Glu 
    290                 295                 300


Glu Arg Glu Glu Ser Pro Asp Lys Pro Gly Ser Pro Cys Ala Ser Cys 
305                 310                 315                 320


Gly Leu Asp Gly His Trp Tyr Arg Ala Leu Leu Leu Glu Thr Phe Arg 
                325                 330                 335


Pro Gln Arg Cys Ala Gln Val Leu His Val Asp Tyr Gly Arg Lys Glu 
            340                 345                 350


Leu Val Ser Cys Ser Ser Leu Arg Tyr Leu Leu Pro Glu Tyr Phe Arg 
        355                 360                 365


Met Pro Val Val Thr Tyr Pro Cys Ala Leu Tyr Gly Leu Trp Asp Gly 
    370                 375                 380


Gly Arg Gly Trp Ser Arg Ser Gln Val Gly Asp Leu Lys Thr Leu Ile 
385                 390                 395                 400


Leu Gly Lys Ala Val Asn Ala Lys Ile Glu Phe Tyr Cys Ser Phe Glu 
                405                 410                 415


His Val Tyr Tyr Val Ser Leu Tyr Gly Glu Asp Gly Ile Asn Leu Asn 
            420                 425                 430


Arg Val Phe Gly Val Gln Ser Cys Cys Leu Ala Asp Arg Val Leu Gln 
        435                 440                 445


Ser Gln Ala Thr Glu Glu Glu Glu Pro Glu Thr Ser Gln Ser Gln Ser 
    450                 455                 460


Pro Ala Glu Glu Val Asp Glu Glu Ile Ser Leu Pro Ala Leu Arg Ser 
465                 470                 475                 480


Ile Arg Leu Lys Met Asn Ala Phe Tyr Asp Ala Gln Val Glu Phe Val 
                485                 490                 495


Lys Asn Pro Ser Glu Phe Trp Ile Arg Leu Arg Lys His Asn Val Thr 
            500                 505                 510


Phe Ser Lys Leu Met Arg Arg Met Cys Gly Phe Tyr Ser Ser Ala Ser 
        515                 520                 525


Lys Leu Asp Gly Val Val Leu Lys Pro Glu Pro Asp Asp Leu Cys Cys 
    530                 535                 540


Val Lys Trp Lys Glu Asn Gly Tyr Tyr Arg Ala Ile Val Thr Lys Leu 
545                 550                 555                 560


Asp Asp Lys Ser Val Asp Val Phe Leu Val Asp Arg Gly Asn Ser Glu 
                565                 570                 575


Asn Val Asp Trp Tyr Asp Val Arg Met Leu Leu Pro Gln Phe Arg Gln 
            580                 585                 590


Leu Pro Ile Leu Ala Val Lys Cys Thr Leu Ala Asp Ile Trp Pro Leu 
        595                 600                 605


Gly Lys Thr Trp Ser Gln Glu Ala Val Ser Phe Phe Lys Lys Thr Val 
    610                 615                 620


Leu His Lys Glu Leu Val Ile His Ile Leu Asp Lys Gln Asp His Gln 
625                 630                 635                 640


Tyr Val Ile Glu Ile Leu Asp Glu Ser Arg Thr Gly Glu Glu Asn Ile 
                645                 650                 655


Ser Lys Val Ile Ala Gln Ala Gly Tyr Ala Lys Tyr Gln Glu Phe Glu 
            660                 665                 670


Thr Lys Glu Asn Ile Leu Val Asn Ala His Ser Pro Gly His Val Ser 
        675                 680                 685


Asn His Phe Thr Thr Glu Ser Asn Lys Ile Pro Phe Ala Lys Thr Gly 
    690                 695                 700


Glu Gly Glu Gln Lys Ala Lys Arg Glu Asn Lys Thr Thr Ser Val Ser 
705                 710                 715                 720


Lys Ala Leu Ser Asp Thr Thr Val Val Thr Asn Gly Ser Thr Glu Leu 
                725                 730                 735


Val Val Gln Glu Lys Val Lys Arg Ala Ser Val Tyr Phe Pro Leu Met 
            740                 745                 750


Gln Asn Cys Leu Glu Ile Lys Pro Gly Ser Ser Ser Lys Gly Glu Leu 
        755                 760                 765


Glu Val Gly Ser Thr Val Glu Val Arg Val Ser Tyr Val Glu Asn Pro 
    770                 775                 780


Gly Tyr Phe Trp Cys Gln Leu Thr Arg Asn Ile Gln Gly Leu Lys Thr 
785                 790                 795                 800


Leu Met Ser Asp Ile Gln Tyr Tyr Cys Lys Asn Thr Ala Ala Pro His 
                805                 810                 815


Gln Arg Asn Thr Leu Ala Cys Leu Ala Lys Arg Thr Val Asn Arg Gln 
            820                 825                 830


Trp Ser Arg Ala Leu Ile Ser Gly Ile Gln Ser Val Glu His Val Asn 
        835                 840                 845


Val Thr Phe Val Asp Tyr Gly Asp Arg Glu Met Val Ser Val Lys Asn 
    850                 855                 860


Ile Tyr Ser Ile Ser Glu Glu Phe Leu Lys Val Lys Ala Gln Ala Phe 
865                 870                 875                 880


Arg Cys Ser Leu Tyr Asn Leu Ile Gln Pro Val Gly Gln Asn Pro Phe 
                885                 890                 895


Val Trp Asp Val Lys Ala Ile Gln Ala Phe Asn Glu Phe Ile Asp Asn 
            900                 905                 910


Ala Trp Gln Lys Asn Leu Glu Leu Lys Cys Thr Ile Phe Ala Leu Ala 
        915                 920                 925


Ser Ile Asn Glu Glu Leu Phe Asn Ile Val Asp Leu Leu Thr Pro Phe 
    930                 935                 940


Gln Ser Ala Cys His Phe Leu Val Glu Lys Arg Leu Ala Arg Pro Val 
945                 950                 955                 960


Lys Leu Gln Lys Pro Leu Glu Ser Ser Val Gln Leu His Ser Tyr Phe 
                965                 970                 975


Tyr Ser Thr His Asp Met Lys Ile Gly Ser Glu Glu Leu Val Tyr Ile 
            980                 985                 990


Thr His Ile Asp Asp Pro Trp Thr Phe Tyr Cys Gln Leu Ala Arg Asn 
        995                 1000                1005


Ala Asn Ile Leu Glu Gln Leu Ser Cys Ser Ile Thr Gln Leu Ser Lys 
    1010                1015                1020


Val Leu Leu Asn Leu Lys Thr Ser Pro Leu Asn Pro Gly Thr Leu Cys 
1025                1030                1035                1040


Leu Ala Lys Tyr Thr Asp Gly Asn Trp Tyr Arg Gly Ile Val Ile Glu 
                1045                1050                1055


Lys Glu Pro Lys Lys Val Phe Phe Val Asp Phe Gly Asn Ile Tyr Val 
            1060                1065                1070


Val Thr Ser Asp Asp Leu Leu Pro Ile Pro Ser Asp Ala Tyr Asp Val 
        1075                1080                1085


Leu Leu Leu Pro Met Gln Ala Val Arg Cys Ser Leu Ser Asp Ile Pro 
    1090                1095                1100


Asp His Ile Pro Glu Glu Val Val Val Trp Phe Gln Glu Thr Ile Leu 
1105                1110                1115                1120


Asp Lys Ser Leu Lys Ala Leu Val Val Ala Lys Asp Pro Asp Gly Thr 
                1125                1130                1135


Leu Ile Ile Glu Leu Tyr Gly Asp Asn Ile Gln Ile Ser Ala Ser Ile 
            1140                1145                1150


Asn Lys Lys Leu Gly Leu Leu Ser Tyr Lys Asp Arg Ile Arg Lys Lys 
        1155                1160                1165


Glu Ser Glu Val Leu Cys Ser Thr Thr Glu Thr Leu Glu Glu Lys Asn 
    1170                1175                1180


Glu Asn Met Lys Leu Pro Cys Thr Glu Tyr Leu Ser Lys Ser Val Gly 
1185                1190                1195                1200


Tyr Lys Leu Pro Asn Lys Glu Ile Leu Glu Glu Ser Tyr Lys Pro Gln 
                1205                1210                1215


Ile Asn Ser Ser Tyr Lys Glu Leu Lys Leu Leu Gln Ser Leu Thr Lys 
            1220                1225                1230


Thr Asn Leu Val Thr Gln Tyr Gln Asp Ser Val Gly Asn Lys Asn Ser 
        1235                1240                1245


Gln Val Phe Pro Leu Thr Thr Glu Lys Lys Glu Glu Ile Ser Ala Glu 
    1250                1255                1260


Thr Pro Leu Lys Thr Ala Arg Val Glu Ala Thr Leu Ser Glu Arg Lys 
1265                1270                1275                1280


Ile Gly Asp Ser Cys Asp Lys Asp Leu Pro Leu Lys Phe Cys Glu Phe 
                1285                1290                1295


Pro Gln Lys Thr Ile Met Pro Gly Phe Lys Thr Thr Val Tyr Val Ser 
            1300                1305                1310


His Ile Asn Asp Leu Ser Asp Phe Tyr Val Gln Leu Ile Glu Asp Glu 
        1315                1320                1325


Ala Glu Ile Ser His Leu Ser Glu Arg Leu Asn Ser Val Lys Thr Arg 
    1330                1335                1340


Pro Glu Tyr Tyr Val Gly Pro Pro Leu Gln Arg Gly Asp Met Ile Cys 
1345                1350                1355                1360


Ala Val Phe Pro Glu Asp Asn Leu Trp Tyr Arg Ala Val Ile Lys Glu 
                1365                1370                1375


Gln Gln Pro Asn Asp Leu Leu Ser Val Gln Phe Ile Asp Tyr Gly Asn 
            1380                1385                1390


Val Ser Val Val His Thr Asn Lys Ile Gly Arg Leu Asp Leu Val Asn 
        1395                1400                1405


Ala Ile Leu Pro Gly Leu Cys Ile His Cys Ser Leu Gln Gly Phe Glu 
    1410                1415                1420


Val Pro Asp Asn Lys Asn Ser Lys Lys Met Met His Tyr Phe Ser Gln 
1425                1430                1435                1440


Arg Thr Ser Glu Ala Ala Ile Arg Cys Glu Phe Val Lys Phe Gln Asp 
                1445                1450                1455


Arg Trp Glu Val Ile Leu Ala Asp Glu His Gly Ile Ile Ala Asp Asp 
            1460                1465                1470


Met Ile Ser Arg Tyr Ala Leu Ser Glu Lys Ser Gln Val Glu Leu Ser 
        1475                1480                1485


Thr Gln Val Ile Lys Ser Ala Ser Ser Lys Ser Val Asn Lys Ser Asp 
    1490                1495                1500


Ile Asp Thr Ser Val Phe Leu Asn Trp Tyr Asn Pro Glu Lys Lys Met 
1505                1510                1515                1520


Ile Arg Ala Tyr Ala Thr Val Ile Asp Gly Pro Glu Tyr Phe Trp Cys 
                1525                1530                1535


Gln Phe Ala Asp Thr Glu Lys Leu Gln Cys Leu Glu Val Glu Val Gln 
            1540                1545                1550


Thr Ala Gly Glu Gln Val Ala Asp Arg Arg Asn Cys Ile Pro Cys Pro 
        1555                1560                1565


Tyr Ile Gly Asp Pro Cys Ile Val Arg Tyr Arg Glu Asp Gly His Tyr 
    1570                1575                1580


Tyr Arg Ala Leu Ile Thr Asn Ile Cys Glu Asp Tyr Leu Val Ser Val 
1585                1590                1595                1600


Arg Leu Val Asp Phe Gly Asn Ile Glu Asp Cys Val Asp Pro Lys Ala 
                1605                1610                1615


Leu Trp Ala Ile Pro Ser Glu Leu Leu Ser Val Pro Met Gln Ala Phe 
            1620                1625                1630


Pro Cys Cys Leu Ser Gly Phe Asn Ile Ser Glu Gly Leu Cys Ser Gln 
        1635                1640                1645


Glu Gly Asn Asp Tyr Phe Tyr Glu Ile Ile Thr Glu Asp Val Leu Glu 
    1650                1655                1660


Ile Thr Ile Leu Glu Ile Arg Arg Asp Val Cys Asp Ile Pro Leu Ala 
1665                1670                1675                1680


Ile Val Asp Leu Lys Ser Lys Gly Lys Ser Ile Asn Glu Lys Met Glu 
                1685                1690                1695


Lys Tyr Ser Lys Thr Gly Ile Lys Ser Ala Leu Pro Tyr Glu Asn Ile 
            1700                1705                1710


Asp Ser Glu Ile Lys Gln Thr Leu Gly Ser Tyr Asn Leu Asp Val Gly 
        1715                1720                1725


Leu Lys Lys Leu Ser Asn Lys Ala Val Gln Asn Lys Ile Tyr Met Glu 
    1730                1735                1740


Gln Gln Thr Asp Glu Leu Ala Glu Ile Thr Glu Lys Asp Val Asn Ile 
1745                1750                1755                1760


Ile Gly Thr Lys Pro Ser Asn Phe Arg Asp Pro Lys Thr Asp Asn Ile 
                1765                1770                1775


Cys Glu Gly Phe Glu Asn Pro Cys Lys Asp Lys Ile Asp Thr Glu Glu 
            1780                1785                1790


Leu Glu Gly Glu Leu Glu Cys His Leu Val Asp Lys Ala Glu Phe Asp 
        1795                1800                1805


Asp Lys Tyr Leu Ile Thr Gly Phe Asn Thr Leu Leu Pro His Ala Asn 
    1810                1815                1820


Glu Thr Lys Glu Ile Leu Glu Leu Asn Ser Leu Glu Val Pro Leu Ser 
1825                1830                1835                1840


Pro Asp Asp Glu Ser Lys Glu Phe Leu Glu Leu Glu Ser Ile Glu Leu 
                1845                1850                1855


Gln Asn Ser Leu Val Val Asp Glu Glu Lys Gly Glu Leu Ser Pro Val 
            1860                1865                1870


Pro Pro Asn Val Pro Leu Ser Gln Glu Cys Val Thr Lys Gly Ala Met 
        1875                1880                1885


Glu Leu Phe Thr Leu Gln Leu Pro Leu Ser Cys Glu Ala Glu Lys Gln 
    1890                1895                1900


Pro Glu Leu Glu Leu Pro Thr Ala Gln Leu Pro Leu Asp Asp Lys Met 
1905                1910                1915                1920


Asp Pro Leu Ser Leu Gly Val Ser Gln Lys Ala Gln Glu Ser Met Cys 
                1925                1930                1935


Thr Glu Asp Met Arg Lys Ser Ser Cys Val Glu Ser Phe Asp Asp Gln 
            1940                1945                1950


Arg Arg Met Ser Leu His Leu His Gly Ala Asp Cys Asp Pro Lys Thr 
        1955                1960                1965


Gln Asn Glu Met Asn Ile Cys Glu Glu Glu Phe Val Glu Tyr Lys Asn 
    1970                1975                1980


Arg Asp Ala Ile Ser Ala Leu Met Pro Leu Phe Ser Glu Glu Glu Ser 
1985                1990                1995                2000


Ser Asp Gly Ser Lys His Asn Asn Gly Leu Pro Asp His Ile Ser Ala 
                2005                2010                2015


Gln Leu Gln Asn Thr Tyr Thr Leu Lys Ala Phe Thr Val Gly Ser Lys 
            2020                2025                2030


Cys Val Val Trp Ser Ser Leu Arg Asn Thr Trp Ser Lys Cys Glu Ile 
        2035                2040                2045


Leu Glu Thr Ala Glu Glu Gly Thr Arg Val Leu Asn Leu Ser Asn Gly 
    2050                2055                2060


Met Glu Glu Ile Val Asn Pro Glu Asn Val Trp Asn Gly Ile Pro Lys 
2065                2070                2075                2080


Leu Asp Lys Ser Pro Pro Glu Lys Arg Gly Leu Glu Val Met Glu Ile 
                2085                2090                2095


<210>  355
<211>  1561
<212>  DNA
<213>  Homo sapiens

<400>  355
cgcacgccac ccgcccgccg cctgccagag ctgctcggcc cgcagccagg gggacagcgg     60

ctggtcggag gctcgcagtg ctgtcggcga gaagcagtcg ggtttggagc gcttgggtcg    120

cgttggtgcg cggtggacac gagggacccc agttcccgcg agcagctccg cgccggccct    180

gagagactaa gctgaaactg ctgctcagct cccaagatgg tgccacccaa attgcatgtg    240

cttttctgcc tctgcggctg cctggctgtg gtttatcctt ttgactggca atacataaat    300

cctgttgccc atatgaaatc atcagcatgg gtcaacaaaa tacaagtact gatggctgct    360

gcaagctttg gccaaactaa aatcccccgg ggaaatgggc cttattccgt tggttgtaca    420

gacttaatgt ttgatcacac taataagggc accttcttgc gtttatatta tccatcccaa    480

gataatgatc gccttgacac cctttggatc ccaaataaag aatatttttg gggtcttagc    540

aaatttcttg gaacacactg gcttatgggc aacattttga ggttactctt tggttcaatg    600

acaactcctg caaactggaa ttcccctctg aggcctggtg aaaaatatcc acttgttgtt    660

ttttctcatg gtcttggggc attcaggaca ctttattctg ctattggcat tgacctggca    720

tctcatgggt ttatagttgc tgctgtagaa cacagagata gatctgcatc tgcaacttac    780

tatttcaagg accaatctgc tgcagaaata ggggacaagt cttggctcta ccttagaacc    840

ctgaaacaag aggaggagac acatatacga aatgagcagg tacggcaaag agcaaaagaa    900

tgttcccaag ctctcagtct gattcttgac attgatcatg gaaagccagt gaagaatgca    960

ttagatttaa agtttgatat ggaacaactg aaggactcta ttgataggga aaaaatagca   1020

gtaattggac attcttttgg tggagcaacg gttattcaga ctcttagtga agatcagaga   1080

ttcagatgtg gtattgccct ggatgcatgg atgtttccac tgggtgatga agtatattcc   1140

agaattcctc agcccctctt ttttatcaac tctgaatatt tccaatatcc tgctaatatc   1200

ataaaaatga aaaaatgcta ctcacctgat aaagaaagaa agatgattac aatcaggggt   1260

tcagtccacc agaattttgc tgacttcact tttgcaactg gcaaaataat tggacacatg   1320

ctcaaattaa agggagacat agattcaaat gcagctattg atcttagcaa caaagcttca   1380

ttagcattct tacaaaagca tttaggactt cataaagatt ttgatcagtg ggactgcttg   1440

attgaaggag atgatgagaa tcttattcca gggaccaaca ttaacacaac caatcaacac   1500

atcatgttac agaactcttc aggaatagag aaatacaatt aggattaaaa taggtttttt   1560

a                                                                   1561


<210>  356
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  356

Met Val Pro Pro Lys Leu His Val Leu Phe Cys Leu Cys Gly Cys Leu 
1               5                   10                  15


Ala Val Val Tyr Pro Phe Asp Trp Gln Tyr Ile Asn Pro Val Ala His 
            20                  25                  30


Met Lys Ser Ser Ala Trp Val Asn Lys Ile Gln Val Leu Met Ala Ala 
        35                  40                  45


Ala Ser Phe Gly Gln Thr Lys Ile Pro Arg Gly Asn Gly Pro Tyr Ser 
    50                  55                  60


Val Gly Cys Thr Asp Leu Met Phe Asp His Thr Asn Lys Gly Thr Phe 
65                  70                  75                  80


Leu Arg Leu Tyr Tyr Pro Ser Gln Asp Asn Asp Arg Leu Asp Thr Leu 
                85                  90                  95


Trp Ile Pro Asn Lys Glu Tyr Phe Trp Gly Leu Ser Lys Phe Leu Gly 
            100                 105                 110


Thr His Trp Leu Met Gly Asn Ile Leu Arg Leu Leu Phe Gly Ser Met 
        115                 120                 125


Thr Thr Pro Ala Asn Trp Asn Ser Pro Leu Arg Pro Gly Glu Lys Tyr 
    130                 135                 140


Pro Leu Val Val Phe Ser His Gly Leu Gly Ala Phe Arg Thr Leu Tyr 
145                 150                 155                 160


Ser Ala Ile Gly Ile Asp Leu Ala Ser His Gly Phe Ile Val Ala Ala 
                165                 170                 175


Val Glu His Arg Asp Arg Ser Ala Ser Ala Thr Tyr Tyr Phe Lys Asp 
            180                 185                 190


Gln Ser Ala Ala Glu Ile Gly Asp Lys Ser Trp Leu Tyr Leu Arg Thr 
        195                 200                 205


Leu Lys Gln Glu Glu Glu Thr His Ile Arg Asn Glu Gln Val Arg Gln 
    210                 215                 220


Arg Ala Lys Glu Cys Ser Gln Ala Leu Ser Leu Ile Leu Asp Ile Asp 
225                 230                 235                 240


His Gly Lys Pro Val Lys Asn Ala Leu Asp Leu Lys Phe Asp Met Glu 
                245                 250                 255


Gln Leu Lys Asp Ser Ile Asp Arg Glu Lys Ile Ala Val Ile Gly His 
            260                 265                 270


Ser Phe Gly Gly Ala Thr Val Ile Gln Thr Leu Ser Glu Asp Gln Arg 
        275                 280                 285


Phe Arg Cys Gly Ile Ala Leu Asp Ala Trp Met Phe Pro Leu Gly Asp 
    290                 295                 300


Glu Val Tyr Ser Arg Ile Pro Gln Pro Leu Phe Phe Ile Asn Ser Glu 
305                 310                 315                 320


Tyr Phe Gln Tyr Pro Ala Asn Ile Ile Lys Met Lys Lys Cys Tyr Ser 
                325                 330                 335


Pro Asp Lys Glu Arg Lys Met Ile Thr Ile Arg Gly Ser Val His Gln 
            340                 345                 350


Asn Phe Ala Asp Phe Thr Phe Ala Thr Gly Lys Ile Ile Gly His Met 
        355                 360                 365


Leu Lys Leu Lys Gly Asp Ile Asp Ser Asn Ala Ala Ile Asp Leu Ser 
    370                 375                 380


Asn Lys Ala Ser Leu Ala Phe Leu Gln Lys His Leu Gly Leu His Lys 
385                 390                 395                 400


Asp Phe Asp Gln Trp Asp Cys Leu Ile Glu Gly Asp Asp Glu Asn Leu 
                405                 410                 415


Ile Pro Gly Thr Asn Ile Asn Thr Thr Asn Gln His Ile Met Leu Gln 
            420                 425                 430


Asn Ser Ser Gly Ile Glu Lys Tyr Asn 
        435                 440


<210>  357
<211>  1163
<212>  DNA
<213>  Homo sapiens

<400>  357
atgacgccgg gcgccatctt tgacgctggc agtcttggtt ttctgctagt gctgctgctg     60

ctgggaggac gacggacggc agcggccaag cgagaagaaa gacgtggcag caagcgggag    120

tcggggatag tgtcatcggt tcgggtccca ctactttgga gcttgtctca aactccacat    180

acagaaagcc accgacctta ttccgattat attgttcagc tatggaagat ggattttttt    240

tcatgatcct ttgactctca agttcatctt taaatgaact cttttttttg ttttgttttt    300

gaggagataa ctaaccctag ctgtctccag tctgacaaag gttatttgaa tggacttaat    360

ctcccagtag ttgggagatg ttttaaaaac acatgctgtg tttgaattgt ggctgagagg    420

ttttcttggc aatgtgagga ggaaaatttt ttctgcttca ttattattaa ttcatggatt    480

gagtgttggt tcgacctaca ggcgtaatag attggaactc agtgaagaca cagacgttcc    540

tgttgagagc aatcagctaa tgattacagt ttaaagacaa tttctgtgat caagttgtca    600

tttggaagat taaacccatt tcacgaggac ttggagcctg gtccttgctt tgaggaagca    660

gtggcttgtt tcaagaagcc acttctgatc taagaatcta cccagcatgc ctaatcaagg    720

agaagactgc tatttttttt tctattctac atgtaccaaa ggtgacagct gcccattccg    780

tcactgtgaa gctgcactag gcaatgaaac tgtttgcaca ttatggcaag aagggcgctg    840

ttttcgacgg gtgtgcaggt ttcggcacat ggagattgat aaaaaacgca gtgaaattcc    900

ttgttattgg gaaaatcagc caacaggatg tcaaaaatta aactgcgctt tccatcacaa    960

tagaggacga tatgttgatg gccttttcct acctccgagc aaaagtgtgt tgcccactgt   1020

gcctgagtca ccagaagagg aagtgaaggc tagccaactt tcagttcagc agaacaaatt   1080

gtctgtccag tccaatcctt cccctcagct gcggagcgtt atgaaagtag aaagttccga   1140

aaatgttcct agccccaagc atc                                           1163


<210>  358
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  358

Met Thr Pro Gly Ala Ile Phe Asp Ala Gly Ser Leu Gly Phe Leu Leu 
1               5                   10                  15


Val Leu Leu Leu Leu Gly Gly Arg Arg Thr Ala Ala Ala Lys Arg Glu 
            20                  25                  30


Glu Arg Arg Gly Ser Lys Arg Glu Ser Gly Ile Val Ser Ser Val Arg 
        35                  40                  45


Val Pro Leu Leu Trp Ser Leu Ser Gln Thr Pro His Thr Glu Ser His 
    50                  55                  60


Arg Pro Tyr Ser Asp Tyr Ile Val Gln Leu Trp Lys Met Asp Phe Phe 
65                  70                  75                  80


Ser 



<210>  359
<211>  4956
<212>  DNA
<213>  Homo sapiens

<400>  359
ggacggcagc ggccaagcga gaagaaagac gtggcagcaa gcgggagtcg gggatagtgt     60

catcggttcg ggtcccacta ctttggagct tgtctcaaac tccacataca gaaagccacc    120

gaccttattc cggtatccta cacccattcc ccaccctcat tacactccca cccctggccc    180

tcagcgtggg agtcaagagc aacagggaca cttccgtact ccttgtagga ttggtgaaac    240

cgtaatgacg aacaccccta aactcccata attggatttg gggatattcc ctgcccaaaa    300

aattcctgga aaattgacta gtattaagtc tatggaagat ggattttttt tcatgatcct    360

ttgactctca agttcatctt taaatgaact cttttttttg ttttgttttt gaggagataa    420

ctaaccctag ctgtctccag tctgacaaag gttatttgaa tggacttaat ctcccagtag    480

ttgggagatg ttttaaaaac acatgctgtg tttgaattgt ggctgagagg ttttcttggc    540

aatgtgagga ggaaaatttt ttctgcttca ttattattaa ttcatggatt gagtgttggt    600

tcgacctaca ggcgtaatag attggaactc agtgaagaca cagacgttcc tgttgagagc    660

aatcagctaa tgattacagt ttaaagacaa tttctgtgat caagttgtca tttggaagat    720

taaacccatt tcacgaggac ttggagcctg gtccttgctt tgaggaagca gtggcttgtt    780

tcaagaagcc acttctgatc taagaatcta cccagcatgc ctaatcaagg agaagactgc    840

tatttttttt tctattctac atgtaccaaa ggtgacagct gcccattccg tcactgtgaa    900

gctgcactag gcaatgaaac tgtttgcaca ttatggcaag aagggcgctg ttttcgacgg    960

gtgtgcaggt ttcggcacat ggagattgat aaaaaacgca gtgaaattcc ttgttattgg   1020

gaaaatcagc caacaggatg tcaaaaatta aactgcgctt tccatcacaa tagaggacga   1080

tatgttgatg gccttttcct acctccgagc aaaagtgtgt tgcccactgt gcctgagtca   1140

ccagaagagg aagtgaaggc tagccaactt tcagttcagc agaacaaatt gtctgtccag   1200

tccaatcctt cccctcagct gcggagcgtt atgaaagtag aaagttccga aaatgttcct   1260

agccccaagc atccaccagt tgtaattaat gctgcagatg atgatgaaga tgatgatgat   1320

cagttttctg aggaaggtga tgaaaccaaa acacctaccc tgcaaccaac tcctgaagtt   1380

cacaatggat tacgagtgac ttctgtccgg aaacctgcag tcaatataaa gcaaggtgaa   1440

tgtttgcatt ttggaataaa aactcttgag gaaattaagt caaagaaaat gaaggaaaaa   1500

tctgaggagc aaggtgaggg ttcttcagga gtttccagtc ttttactcca ccctgagcct   1560

gttccaggtc ctgaaaaaga aaatgtcagg actgtggtga ggacagtaac tctctccacc   1620

aaacaaggag aagaaccctt ggttagattg ggccttactg agacactggg gaaacgaaaa   1680

ttttcgacag gcggtgacag tgatcctcca ttaaagcgca gcctggcaca gaggctaggg   1740

aagaaagttg aagctccaga aactaacact gacgaaacac caaagaaagc tcaagtttcc   1800

aagtctctta aggagcgatt aggcatgtca gctgatccaa ataatgagga cgcaacagat   1860

aaagttaata aagttggtga gatccatgtg aagacattag aagaaatgct tcttgaaaga   1920

gccagtcaga aacatgggga atcgcaaact aaactcaaga cagaaggacc ttcaaaaact   1980

gatgattcta cttcaggagc aagaagctcc tccactatcc gtatcaaaac cttctctgag   2040

gtcctggctg aagaagaaca taggcagcag gaagcagaga gacaaaaaag caaaaaggat   2100

acaacttgca tcaagctaaa gactgatagt gaaattaaaa aaacagtagt tttgccaccc   2160

attgttgcca gcaaaggaca atcagaggag cctgcaggta aaacaaagtc catgcaggag   2220

gtgcacatga agacggtgga agaaattaaa ctggagaagg cactgagggt gcagcagagc   2280

tctgagagca gcaccagctc cccgtctcaa catgaggcca ctccaggggc aaggttgcta   2340

ctgcgaatca ccaaaagaac atggaggaaa gaagagaaga aacttcagga aggaaatgaa   2400

gttgattttc tgagccgtgt tagaatggaa gctacagagg cttcagttga gaccacagga   2460

gttgacatca ctaaaattca agtcaagaga tgtgagatca tgagagagac gcgcatgcag   2520

aaacagcagg agagggaaaa atcagtcttg acacctcttc agggagatgt agcctcttgc   2580

aatacccaag tggcagagaa accagtgctc actgctgtgc caggaatcac atggcacctg   2640

accaagcagc ttcccacaaa gtcatcccag aaggtggagg tagaaacctc agggattgca   2700

gactcattat tgaatgtgaa atggtcagca cagaccttgg aaaaaagggg tgaagctaaa   2760

cccacagtga acgtgaagca atctgtggtt aaagttgtgt catcccccaa attggcccca   2820

aaacgtaagg cagtggagat gcaccctgct gtcactgccg ctgtgaagcc actcagctcc   2880

agcagcgtcc tacaggaacc cccagccaaa aaggcagctg tggatgctgt tgtcctgctt   2940

gtctctgagg acaaatcagt cactgtgcct gaaacagaaa atcctagaga cagtcttgtg   3000

ctgcctctaa cccagtcctc ttcagattcc tcacccccgg aggtgtctgg cccttcctca   3060

tcccaaatga gcatgaaaac tcgccgactc agctctgcct caacaggaaa gcccccactc   3120

tctgtggagg atgattttga gaaactaaca tgggagattt caggaggcaa attggaagct   3180

gagattgacc tggatcctgg gaaagatgaa gatgaccttc cgcttgagct atgagaaatg   3240

attgatagct gaaggtggta gtgaggacac tttaaaaaaa aatcgccaaa aaactggact   3300

tagtttcatc tattgtaaca tttacctgag atgatcattt ctttagtcta gaatttgccc   3360

caaatcagaa gtatacctct gaattatctg tatgtgtcct ggattccttg gggtcagatt   3420

tttaaagtta ctttataacc attttgtcca tttgatgcca ttgtttatca tcttttgaga   3480

aaaaagttct gtcataccct tctctccaca aaaaagagac tgagagggag atcaagtgaa   3540

agggtgcaag caaacttagt gactccttga ggtgtttgtc agttttggct tttttctcct   3600

ttgttgtatt ctttatgtat tgtcttgatg tacttaatat tacctgagtt tgaaatggat   3660

gaagacagct gctaccatta aggaccaaat tttatgctac cactaaacaa aaatacccac   3720

tcagtctgtg ttagattgta tgtcttttta aaggtattta gagattcaac taagctttaa   3780

agagggctga gcagctcagg aagcctgtaa tgtgggcata actctttgga cctgatcttg   3840

atgcttctgc tgctctgttg gcctctgaag agcaatatct aatttattat tactgtaatt   3900

ttttaaaagg ctttaaagtg cctcaggggt cccctgaaac taattttcta tttctgggat   3960

tccctggatt cattatatga gatggtgaca tgattagagg aattcttttt tagtatgaaa   4020

attgtccctt ttcttcttca gtacttgcct ccttgctggc attgaattaa cacagggaca   4080

aaatatggtt aattttttat ttctaattct cccaacaaac ccctgttgcc cagtatttat   4140

gtggtggcct ttaaccacct gagggaaaaa atgagcttat tcaagctgcc aatatttatc   4200

tatgggctgt agcagtacac tgaattgtac tgtgccaggg atattgagat gctctggggg   4260

tatattgtat acctgccagt tttcttcatt tctgaattga gttttctttt cttgatgttg   4320

gtttccttca tatcacctca aggtttagat ttgtgaagga ataagcatga tggaaataat   4380

agtcttgaaa ggagatatgt tgtatataat caggaggaag aggaaggaag gacttaccca   4440

ttttgatatt ttgctgtagg tggccagttt tgtttctcat agggaaatct gacccccacc   4500

tgtcatgttg gctcctaagg aactgctgtt gtaagcggct catcaagagt tgaacttcac   4560

gtagccttgt tgggaatatg gaaaaggaag aaagccacag gactgcccat tcagtcttgt   4620

taagattggg atgattctgc acaagcaaaa atgacttgaa atttatgtat cgacacacct   4680

ctaccaatcc atcttcagct gactgaatgt tgtatgatag cccttctcca aagcaggggt   4740

agaatgttca ggtttcacca cggattttct acttatttcg cttttggaat cagcttacag   4800

attccaggtc ccttttgtag atattcttta ttcttttgct tttttaaaaa ataaactggt   4860

attagtcaat gtttcgtgtt ccgcattatt tgaaccattt gcccttacag aaagagaaat   4920

acttgtttgt gttttaaata aaactgatgt aggata                             4956


<210>  360
<211>  805
<212>  PRT
<213>  Homo sapiens

<400>  360

Met Pro Asn Gln Gly Glu Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys 
1               5                   10                  15


Thr Lys Gly Asp Ser Cys Pro Phe Arg His Cys Glu Ala Ala Leu Gly 
            20                  25                  30


Asn Glu Thr Val Cys Thr Leu Trp Gln Glu Gly Arg Cys Phe Arg Arg 
        35                  40                  45


Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile 
    50                  55                  60


Pro Cys Tyr Trp Glu Asn Gln Pro Thr Gly Cys Gln Lys Leu Asn Cys 
65                  70                  75                  80


Ala Phe His His Asn Arg Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro 
                85                  90                  95


Pro Ser Lys Ser Val Leu Pro Thr Val Pro Glu Ser Pro Glu Glu Glu 
            100                 105                 110


Val Lys Ala Ser Gln Leu Ser Val Gln Gln Asn Lys Leu Ser Val Gln 
        115                 120                 125


Ser Asn Pro Ser Pro Gln Leu Arg Ser Val Met Lys Val Glu Ser Ser 
    130                 135                 140


Glu Asn Val Pro Ser Pro Lys His Pro Pro Val Val Ile Asn Ala Ala 
145                 150                 155                 160


Asp Asp Asp Glu Asp Asp Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu 
                165                 170                 175


Thr Lys Thr Pro Thr Leu Gln Pro Thr Pro Glu Val His Asn Gly Leu 
            180                 185                 190


Arg Val Thr Ser Val Arg Lys Pro Ala Val Asn Ile Lys Gln Gly Glu 
        195                 200                 205


Cys Leu His Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys 
    210                 215                 220


Met Lys Glu Lys Ser Glu Glu Gln Gly Glu Gly Ser Ser Gly Val Ser 
225                 230                 235                 240


Ser Leu Leu Leu His Pro Glu Pro Val Pro Gly Pro Glu Lys Glu Asn 
                245                 250                 255


Val Arg Thr Val Val Arg Thr Val Thr Leu Ser Thr Lys Gln Gly Glu 
            260                 265                 270


Glu Pro Leu Val Arg Leu Gly Leu Thr Glu Thr Leu Gly Lys Arg Lys 
        275                 280                 285


Phe Ser Thr Gly Gly Asp Ser Asp Pro Pro Leu Lys Arg Ser Leu Ala 
    290                 295                 300


Gln Arg Leu Gly Lys Lys Val Glu Ala Pro Glu Thr Asn Thr Asp Glu 
305                 310                 315                 320


Thr Pro Lys Lys Ala Gln Val Ser Lys Ser Leu Lys Glu Arg Leu Gly 
                325                 330                 335


Met Ser Ala Asp Pro Asn Asn Glu Asp Ala Thr Asp Lys Val Asn Lys 
            340                 345                 350


Val Gly Glu Ile His Val Lys Thr Leu Glu Glu Met Leu Leu Glu Arg 
        355                 360                 365


Ala Ser Gln Lys His Gly Glu Ser Gln Thr Lys Leu Lys Thr Glu Gly 
    370                 375                 380


Pro Ser Lys Thr Asp Asp Ser Thr Ser Gly Ala Arg Ser Ser Ser Thr 
385                 390                 395                 400


Ile Arg Ile Lys Thr Phe Ser Glu Val Leu Ala Glu Glu Glu His Arg 
                405                 410                 415


Gln Gln Glu Ala Glu Arg Gln Lys Ser Lys Lys Asp Thr Thr Cys Ile 
            420                 425                 430


Lys Leu Lys Thr Asp Ser Glu Ile Lys Lys Thr Val Val Leu Pro Pro 
        435                 440                 445


Ile Val Ala Ser Lys Gly Gln Ser Glu Glu Pro Ala Gly Lys Thr Lys 
    450                 455                 460


Ser Met Gln Glu Val His Met Lys Thr Val Glu Glu Ile Lys Leu Glu 
465                 470                 475                 480


Lys Ala Leu Arg Val Gln Gln Ser Ser Glu Ser Ser Thr Ser Ser Pro 
                485                 490                 495


Ser Gln His Glu Ala Thr Pro Gly Ala Arg Leu Leu Leu Arg Ile Thr 
            500                 505                 510


Lys Arg Thr Trp Arg Lys Glu Glu Lys Lys Leu Gln Glu Gly Asn Glu 
        515                 520                 525


Val Asp Phe Leu Ser Arg Val Arg Met Glu Ala Thr Glu Ala Ser Val 
    530                 535                 540


Glu Thr Thr Gly Val Asp Ile Thr Lys Ile Gln Val Lys Arg Cys Glu 
545                 550                 555                 560


Ile Met Arg Glu Thr Arg Met Gln Lys Gln Gln Glu Arg Glu Lys Ser 
                565                 570                 575


Val Leu Thr Pro Leu Gln Gly Asp Val Ala Ser Cys Asn Thr Gln Val 
            580                 585                 590


Ala Glu Lys Pro Val Leu Thr Ala Val Pro Gly Ile Thr Trp His Leu 
        595                 600                 605


Thr Lys Gln Leu Pro Thr Lys Ser Ser Gln Lys Val Glu Val Glu Thr 
    610                 615                 620


Ser Gly Ile Ala Asp Ser Leu Leu Asn Val Lys Trp Ser Ala Gln Thr 
625                 630                 635                 640


Leu Glu Lys Arg Gly Glu Ala Lys Pro Thr Val Asn Val Lys Gln Ser 
                645                 650                 655


Val Val Lys Val Val Ser Ser Pro Lys Leu Ala Pro Lys Arg Lys Ala 
            660                 665                 670


Val Glu Met His Pro Ala Val Thr Ala Ala Val Lys Pro Leu Ser Ser 
        675                 680                 685


Ser Ser Val Leu Gln Glu Pro Pro Ala Lys Lys Ala Ala Val Asp Ala 
    690                 695                 700


Val Val Leu Leu Val Ser Glu Asp Lys Ser Val Thr Val Pro Glu Thr 
705                 710                 715                 720


Glu Asn Pro Arg Asp Ser Leu Val Leu Pro Leu Thr Gln Ser Ser Ser 
                725                 730                 735


Asp Ser Ser Pro Pro Glu Val Ser Gly Pro Ser Ser Ser Gln Met Ser 
            740                 745                 750


Met Lys Thr Arg Arg Leu Ser Ser Ala Ser Thr Gly Lys Pro Pro Leu 
        755                 760                 765


Ser Val Glu Asp Asp Phe Glu Lys Leu Thr Trp Glu Ile Ser Gly Gly 
    770                 775                 780


Lys Leu Glu Ala Glu Ile Asp Leu Asp Pro Gly Lys Asp Glu Asp Asp 
785                 790                 795                 800


Leu Pro Leu Glu Leu 
                805


<210>  361
<211>  4494
<212>  DNA
<213>  Homo sapiens

<400>  361
gctagtgctg ctgctgctgg gaggacgacg gacggcagcg gccaagcgag aagaaagacg     60

tggcagcaag cgggagtcgg ggatagtgtc atcggatttg gggatattcc ctgcccaaaa    120

aattcctgga aaattgacta gtattaagtg cgtaatagat tggaactcag tgaagacaca    180

gacgttcctg ttgagagcaa tcagctaatg attacagttt aaagacaatt tctgtgatca    240

agttgtcatt tggaagatta aacccatttc acgaggactt ggagcctggt ccttgctttg    300

aggaagcagt ggcttgtttc aagaagccac ttctgatcta agaatctacc cagcatgcct    360

aatcaaggag aagactgcta tttttttttc tattctacat gtaccaaagg tgacagctgc    420

ccattccgtc actgtgaagc tgcactaggc aatgaaactg tttgcacatt atggcaagaa    480

gggcgctgtt ttcgacgggt gtgcaggttt cggcacatgg agattgataa aaaacgcagt    540

gaaattcctt gttattggga aaatcagcca acaggatgtc aaaaattaaa ctgcgctttc    600

catcacaata gaggacgata tgttgatggc cttttcctac ctccgagcaa aagtgtgttg    660

cccactgtgc ctgagtcacc agaagaggaa gtgaaggcta gccaactttc agttcagcag    720

aacaaattgt ctgtccagtc caatccttcc cctcagctgc ggagcgttat gaaagtagaa    780

agttccgaaa atgttcctag ccccaagcat ccaccagttg taattaatgc tgcagatgat    840

gatgaagatg atgatgatca gttttctgag gaaggtgatg aaaccaaaac acctaccctg    900

caaccaactc ctgaagttca caatggatta cgagtgactt ctgtccggaa acctgcagtc    960

aatataaagc aaggtgaatg tttgcatttt ggaataaaaa ctcttgagga aattaagtca   1020

aagaaaatga aggaaaaatc tgaggagcaa ggtgagggtt cttcaggagt ttccagtctt   1080

ttactccacc ctgagcctgt tccaggtcct gaaaaagaaa atgtcaggac tgtggtgagg   1140

acagtaactc tctccaccaa acaaggagaa gaacccttgg ttagattggg ccttactgag   1200

acactgggga aacgaaaatt ttcgacaggc ggtgacagtg atcctccatt aaagcgcagc   1260

ctggcacaga ggctagggaa gaaagttgaa gctccagaaa ctaacactga cgaaacacca   1320

aagaaagctc aagtttccaa gtctcttaag gagcgattag gcatgtcagc tgatccaaat   1380

aatgaggacg caacagataa agttaataaa gttggtgaga tccatgtgaa gacattagaa   1440

gaaatgcttc ttgaaagagc cagtcagaaa catggggaat cgcaaactaa actcaagaca   1500

gaaggacctt caaaaactga tgattctact tcaggagcaa gaagctcctc cactatccgt   1560

atcaaaacct tctctgaggt cctggctgaa gaagaacata ggcagcagga agcagagaga   1620

caaaaaagca aaaaggatac aacttgcatc aagctaaaga ctgatagtga aattaaaaaa   1680

acagtagttt tgccacccat tgttgccagc aaaggacaat cagaggagcc tgcaggtaaa   1740

acaaagtcca tgcaggaggt gcacatgaag acggtggaag aaattaaact ggagaaggca   1800

ctgagggtgc agcagagctc tgagagcagc accagctccc cgtctcaaca tgaggccact   1860

ccaggggcaa ggttgctact gcgaatcacc aaaagaacat ggaggaaaga agagaagaaa   1920

cttcaggaag gaaatgaagt tgattttctg agccgtgtta gaatggaagc tacagaggct   1980

tcagttgaga ccacaggagt tgacatcact aaaattcaag tcaagagatg tgagatcatg   2040

agagagacgc gcatgcagaa acagcaggag agggaaaaat cagtcttgac acctcttcag   2100

ggagatgtag cctcttgcaa tacccaagtg gcagagaaac cagtgctcac tgctgtgcca   2160

ggaatcacat ggcacctgac caagcagctt cccacaaagt catcccagaa ggtggaggta   2220

gaaacctcag ggattgcaga ctcattattg aatgtgaaat ggtcagcaca gaccttggaa   2280

aaaaggggtg aagctaaacc cacagtgaac gtgaagcaat ctgtggttaa agttgtgtca   2340

tcccccaaat tggccccaaa acgtaaggca gtggagatgc accctgctgt cactgccgct   2400

gtgaagccac tcagctccag cagcgtccta caggaacccc cagccaaaaa ggcagctgtg   2460

gatgctgttg tcctgcttgt ctctgaggac aaatcagtca ctgtgcctga aacagaaaat   2520

cctagagaca gtcttgtgct gcctctaacc cagtcctctt cagattcctc acccccggag   2580

gtgtctggcc cttcctcatc ccaaatgagc atgaaaactc gccgactcag ctctgcctca   2640

acaggaaagc ccccactctc tgtggaggat gattttgaga aactaacatg ggagatttca   2700

ggaggcaaat tggaagctga gattgacctg gatcctggga aagatgaaga tgaccttccg   2760

cttgagctat gagaaatgat tgatagctga aggtggtagt gaggacactt taaaaaaaaa   2820

tcgccaaaaa actggactta gtttcatcta ttgtaacatt tacctgagat gatcatttct   2880

ttagtctaga atttgcccca aatcagaagt atacctctga attatctgta tgtgtcctgg   2940

attccttggg gtcagatttt taaagttact ttataaccat tttgtccatt tgatgccatt   3000

gtttatcatc ttttgagaaa aaagttctgt catacccttc tctccacaaa aaagagactg   3060

agagggagat caagtgaaag ggtgcaagca aacttagtga ctccttgagg tgtttgtcag   3120

ttttggcttt tttctccttt gttgtattct ttatgtattg tcttgatgta cttaatatta   3180

cctgagtttg aaatggatga agacagctgc taccattaag gaccaaattt tatgctacca   3240

ctaaacaaaa atacccactc agtctgtgtt agattgtatg tctttttaaa ggtatttaga   3300

gattcaacta agctttaaag agggctgagc agctcaggaa gcctgtaatg tgggcataac   3360

tctttggacc tgatcttgat gcttctgctg ctctgttggc ctctgaagag caatatctaa   3420

tttattatta ctgtaatttt ttaaaaggct ttaaagtgcc tcaggggtcc cctgaaacta   3480

attttctatt tctgggattc cctggattca ttatatgaga tggtgacatg attagaggaa   3540

ttctttttta gtatgaaaat tgtccctttt cttcttcagt acttgcctcc ttgctggcat   3600

tgaattaaca cagggacaaa atatggttaa ttttttattt ctaattctcc caacaaaccc   3660

ctgttgccca gtatttatgt ggtggccttt aaccacctga gggaaaaaat gagcttattc   3720

aagctgccaa tatttatcta tgggctgtag cagtacactg aattgtactg tgccagggat   3780

attgagatgc tctgggggta tattgtatac ctgccagttt tcttcatttc tgaattgagt   3840

tttcttttct tgatgttggt ttccttcata tcacctcaag gtttagattt gtgaaggaat   3900

aagcatgatg gaaataatag tcttgaaagg agatatgttg tatataatca ggaggaagag   3960

gaaggaagga cttacccatt ttgatatttt gctgtaggtg gccagttttg tttctcatag   4020

ggaaatctga cccccacctg tcatgttggc tcctaaggaa ctgctgttgt aagcggctca   4080

tcaagagttg aacttcacgt agccttgttg ggaatatgga aaaggaagaa agccacagga   4140

ctgcccattc agtcttgtta agattgggat gattctgcac aagcaaaaat gacttgaaat   4200

ttatgtatcg acacacctct accaatccat cttcagctga ctgaatgttg tatgatagcc   4260

cttctccaaa gcaggggtag aatgttcagg tttcaccacg gattttctac ttatttcgct   4320

tttggaatca gcttacagat tccaggtccc ttttgtagat attctttatt cttttgcttt   4380

tttaaaaaat aaactggtat tagtcaatgt ttcgtgttcc gcattatttg aaccatttgc   4440

ccttacagaa agagaaatac ttgtttgtgt tttaaataaa actgatgtag gata         4494


<210>  362
<211>  805
<212>  PRT
<213>  Homo sapiens

<400>  362

Met Pro Asn Gln Gly Glu Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys 
1               5                   10                  15


Thr Lys Gly Asp Ser Cys Pro Phe Arg His Cys Glu Ala Ala Leu Gly 
            20                  25                  30


Asn Glu Thr Val Cys Thr Leu Trp Gln Glu Gly Arg Cys Phe Arg Arg 
        35                  40                  45


Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile 
    50                  55                  60


Pro Cys Tyr Trp Glu Asn Gln Pro Thr Gly Cys Gln Lys Leu Asn Cys 
65                  70                  75                  80


Ala Phe His His Asn Arg Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro 
                85                  90                  95


Pro Ser Lys Ser Val Leu Pro Thr Val Pro Glu Ser Pro Glu Glu Glu 
            100                 105                 110


Val Lys Ala Ser Gln Leu Ser Val Gln Gln Asn Lys Leu Ser Val Gln 
        115                 120                 125


Ser Asn Pro Ser Pro Gln Leu Arg Ser Val Met Lys Val Glu Ser Ser 
    130                 135                 140


Glu Asn Val Pro Ser Pro Lys His Pro Pro Val Val Ile Asn Ala Ala 
145                 150                 155                 160


Asp Asp Asp Glu Asp Asp Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu 
                165                 170                 175


Thr Lys Thr Pro Thr Leu Gln Pro Thr Pro Glu Val His Asn Gly Leu 
            180                 185                 190


Arg Val Thr Ser Val Arg Lys Pro Ala Val Asn Ile Lys Gln Gly Glu 
        195                 200                 205


Cys Leu His Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys 
    210                 215                 220


Met Lys Glu Lys Ser Glu Glu Gln Gly Glu Gly Ser Ser Gly Val Ser 
225                 230                 235                 240


Ser Leu Leu Leu His Pro Glu Pro Val Pro Gly Pro Glu Lys Glu Asn 
                245                 250                 255


Val Arg Thr Val Val Arg Thr Val Thr Leu Ser Thr Lys Gln Gly Glu 
            260                 265                 270


Glu Pro Leu Val Arg Leu Gly Leu Thr Glu Thr Leu Gly Lys Arg Lys 
        275                 280                 285


Phe Ser Thr Gly Gly Asp Ser Asp Pro Pro Leu Lys Arg Ser Leu Ala 
    290                 295                 300


Gln Arg Leu Gly Lys Lys Val Glu Ala Pro Glu Thr Asn Thr Asp Glu 
305                 310                 315                 320


Thr Pro Lys Lys Ala Gln Val Ser Lys Ser Leu Lys Glu Arg Leu Gly 
                325                 330                 335


Met Ser Ala Asp Pro Asn Asn Glu Asp Ala Thr Asp Lys Val Asn Lys 
            340                 345                 350


Val Gly Glu Ile His Val Lys Thr Leu Glu Glu Met Leu Leu Glu Arg 
        355                 360                 365


Ala Ser Gln Lys His Gly Glu Ser Gln Thr Lys Leu Lys Thr Glu Gly 
    370                 375                 380


Pro Ser Lys Thr Asp Asp Ser Thr Ser Gly Ala Arg Ser Ser Ser Thr 
385                 390                 395                 400


Ile Arg Ile Lys Thr Phe Ser Glu Val Leu Ala Glu Glu Glu His Arg 
                405                 410                 415


Gln Gln Glu Ala Glu Arg Gln Lys Ser Lys Lys Asp Thr Thr Cys Ile 
            420                 425                 430


Lys Leu Lys Thr Asp Ser Glu Ile Lys Lys Thr Val Val Leu Pro Pro 
        435                 440                 445


Ile Val Ala Ser Lys Gly Gln Ser Glu Glu Pro Ala Gly Lys Thr Lys 
    450                 455                 460


Ser Met Gln Glu Val His Met Lys Thr Val Glu Glu Ile Lys Leu Glu 
465                 470                 475                 480


Lys Ala Leu Arg Val Gln Gln Ser Ser Glu Ser Ser Thr Ser Ser Pro 
                485                 490                 495


Ser Gln His Glu Ala Thr Pro Gly Ala Arg Leu Leu Leu Arg Ile Thr 
            500                 505                 510


Lys Arg Thr Trp Arg Lys Glu Glu Lys Lys Leu Gln Glu Gly Asn Glu 
        515                 520                 525


Val Asp Phe Leu Ser Arg Val Arg Met Glu Ala Thr Glu Ala Ser Val 
    530                 535                 540


Glu Thr Thr Gly Val Asp Ile Thr Lys Ile Gln Val Lys Arg Cys Glu 
545                 550                 555                 560


Ile Met Arg Glu Thr Arg Met Gln Lys Gln Gln Glu Arg Glu Lys Ser 
                565                 570                 575


Val Leu Thr Pro Leu Gln Gly Asp Val Ala Ser Cys Asn Thr Gln Val 
            580                 585                 590


Ala Glu Lys Pro Val Leu Thr Ala Val Pro Gly Ile Thr Trp His Leu 
        595                 600                 605


Thr Lys Gln Leu Pro Thr Lys Ser Ser Gln Lys Val Glu Val Glu Thr 
    610                 615                 620


Ser Gly Ile Ala Asp Ser Leu Leu Asn Val Lys Trp Ser Ala Gln Thr 
625                 630                 635                 640


Leu Glu Lys Arg Gly Glu Ala Lys Pro Thr Val Asn Val Lys Gln Ser 
                645                 650                 655


Val Val Lys Val Val Ser Ser Pro Lys Leu Ala Pro Lys Arg Lys Ala 
            660                 665                 670


Val Glu Met His Pro Ala Val Thr Ala Ala Val Lys Pro Leu Ser Ser 
        675                 680                 685


Ser Ser Val Leu Gln Glu Pro Pro Ala Lys Lys Ala Ala Val Asp Ala 
    690                 695                 700


Val Val Leu Leu Val Ser Glu Asp Lys Ser Val Thr Val Pro Glu Thr 
705                 710                 715                 720


Glu Asn Pro Arg Asp Ser Leu Val Leu Pro Leu Thr Gln Ser Ser Ser 
                725                 730                 735


Asp Ser Ser Pro Pro Glu Val Ser Gly Pro Ser Ser Ser Gln Met Ser 
            740                 745                 750


Met Lys Thr Arg Arg Leu Ser Ser Ala Ser Thr Gly Lys Pro Pro Leu 
        755                 760                 765


Ser Val Glu Asp Asp Phe Glu Lys Leu Thr Trp Glu Ile Ser Gly Gly 
    770                 775                 780


Lys Leu Glu Ala Glu Ile Asp Leu Asp Pro Gly Lys Asp Glu Asp Asp 
785                 790                 795                 800


Leu Pro Leu Glu Leu 
                805


<210>  363
<211>  4726
<212>  DNA
<213>  Homo sapiens

<400>  363
gacgctggca gtcttggttt tctgctagtg ctgctgctgc tgggaggacg acggacggca     60

gcggccaagc gagaagaaag acgtggcagc aagcgggagt cggggatagt gtcatcggtt    120

cgggtcccac tactttggag cttgtctcaa actccacata cagaaagcca ccgaccttat    180

tccggtatcc tacacccatt ccccaccctc attacactcc cacccctggc cctcagcgtg    240

ggagtcaaga gcaacaggga cacttccgta ctccttgtag gattggtgaa accgtaatga    300

cgaacacccc taaactccca taattggatt tggggatatt ccctgcccaa aaaattcctg    360

gaaaattgac tagtattaag tgcgtaatag attggaactc agtgaagaca cagacgttcc    420

tgttgagagc aatcagctaa tgattacagt ttaaagacaa tttctgtgat caagttgtca    480

tttggaagat taaacccatt tcacgaggac ttggagcctg gtccttgctt tgaggaagca    540

gtggcttgtt tcaagaagcc acttctgatc taagaatcta cccagcatgc ctaatcaagg    600

agaagactgc tatttttttt tctattctac atgtaccaaa ggtgacagct gcccattccg    660

tcactgtgaa gctgcactag gcaatgaaac tgtttgcaca ttatggcaag aagggcgctg    720

ttttcgacgg gtgtgcaggt ttcggcacat ggagattgat aaaaaacgca gtgaaattcc    780

ttgttattgg gaaaatcagc caacaggatg tcaaaaatta aactgcgctt tccatcacaa    840

tagaggacga tatgttgatg gccttttcct acctccgagc aaaagtgtgt tgcccactgt    900

gcctgagtca ccagaagagg aagtgaaggc tagccaactt tcagttcagc agaacaaatt    960

gtctgtccag tccaatcctt cccctcagct gcggagcgtt atgaaagtag aaagttccga   1020

aaatgttcct agccccaagc atccaccagt tgtaattaat gctgcagatg atgatgaaga   1080

tgatgatgat cagttttctg aggaaggtga tgaaaccaaa acacctaccc tgcaaccaac   1140

tcctgaagtt cacaatggat tacgagtgac ttctgtccgg aaacctgcag tcaatataaa   1200

gcaaggtgaa tgtttgcatt ttggaataaa aactcttgag gaaattaagt caaagaaaat   1260

gaaggaaaaa tctgaggagc aaggtgaggg ttcttcagga gtttccagtc ttttactcca   1320

ccctgagcct gttccaggtc ctgaaaaaga aaatgtcagg actgtggtga ggacagtaac   1380

tctctccacc aaacaaggag aagaaccctt ggttagattg ggccttactg agacactggg   1440

gaaacgaaaa ttttcgacag gcggtgacag tgatcctcca ttaaagcgca gcctggcaca   1500

gaggctaggg aagaaagttg aagctccaga aactaacact gacgaaacac caaagaaagc   1560

tcaagtttcc aagtctctta aggagcgatt aggcatgtca gctgatccaa ataatgagga   1620

cgcaacagat aaagttaata aagttggtga gatccatgtg aagacattag aagaaatgct   1680

tcttgaaaga gccagtcaga aacatgggga atcgcaaact aaactcaaga cagaaggacc   1740

ttcaaaaact gatgattcta cttcaggagc aagaagctcc tccactatcc gtatcaaaac   1800

cttctctgag gtcctggctg aagaagaaca taggcagcag gaagcagaga gacaaaaaag   1860

caaaaaggat acaacttgca tcaagctaaa gactgatagt gaaattaaaa aaacagtagt   1920

tttgccaccc attgttgcca gcaaaggaca atcagaggag cctgcaggta aaacaaagtc   1980

catgcaggag gtgcacatga agacggtgga agaaattaaa ctggagaagg cactgagggt   2040

gcagcagagc tctgagagca gcaccagctc cccgtctcaa catgaggcca ctccaggggc   2100

aaggttgcta ctgcgaatca ccaaaagaac atggaggaaa gaagagaaga aacttcagga   2160

aggaaatgaa gttgattttc tgagccgtgt tagaatggaa gctacagagg cttcagttga   2220

gaccacagga gttgacatca ctaaaattca agtcaagaga tgtgagatca tgagagagac   2280

gcgcatgcag aaacagcagg agagggaaaa atcagtcttg acacctcttc agggagatgt   2340

agcctcttgc aatacccaag tggcagagaa accagtgctc actgctgtgc caggaatcac   2400

atggcacctg accaagcagc ttcccacaaa gtcatcccag aaggtggagg tagaaacctc   2460

agggattgca gactcattat tgaatgtgaa atggtcagca cagaccttgg aaaaaagggg   2520

tgaagctaaa cccacagtga acgtgaagca atctgtggtt aaagttgtgt catcccccaa   2580

attggcccca aaacgtaagg cagtggagat gcaccctgct gtcactgccg ctgtgaagcc   2640

actcagctcc agcagcgtcc tacaggaacc cccagccaaa aaggcagctg tggatgctgt   2700

tgtcctgctt gtctctgagg acaaatcagt cactgtgcct gaaacagaaa atcctagaga   2760

cagtcttgtg ctgcctctaa cccagtcctc ttcagattcc tcacccccgg aggtgtctgg   2820

cccttcctca tcccaaatga gcatgaaaac tcgccgactc agctctgcct caacaggaaa   2880

gcccccactc tctgtggagg atgattttga gaaactaaca tgggagattt caggaggcaa   2940

attggaagct gagattgacc tggatcctgg gaaagatgaa gatgaccttc cgcttgagct   3000

atgagaaatg attgatagct gaaggtggta gtgaggacac tttaaaaaaa aatcgccaaa   3060

aaactggact tagtttcatc tattgtaaca tttacctgag atgatcattt ctttagtcta   3120

gaatttgccc caaatcagaa gtatacctct gaattatctg tatgtgtcct ggattccttg   3180

gggtcagatt tttaaagtta ctttataacc attttgtcca tttgatgcca ttgtttatca   3240

tcttttgaga aaaaagttct gtcataccct tctctccaca aaaaagagac tgagagggag   3300

atcaagtgaa agggtgcaag caaacttagt gactccttga ggtgtttgtc agttttggct   3360

tttttctcct ttgttgtatt ctttatgtat tgtcttgatg tacttaatat tacctgagtt   3420

tgaaatggat gaagacagct gctaccatta aggaccaaat tttatgctac cactaaacaa   3480

aaatacccac tcagtctgtg ttagattgta tgtcttttta aaggtattta gagattcaac   3540

taagctttaa agagggctga gcagctcagg aagcctgtaa tgtgggcata actctttgga   3600

cctgatcttg atgcttctgc tgctctgttg gcctctgaag agcaatatct aatttattat   3660

tactgtaatt ttttaaaagg ctttaaagtg cctcaggggt cccctgaaac taattttcta   3720

tttctgggat tccctggatt cattatatga gatggtgaca tgattagagg aattcttttt   3780

tagtatgaaa attgtccctt ttcttcttca gtacttgcct ccttgctggc attgaattaa   3840

cacagggaca aaatatggtt aattttttat ttctaattct cccaacaaac ccctgttgcc   3900

cagtatttat gtggtggcct ttaaccacct gagggaaaaa atgagcttat tcaagctgcc   3960

aatatttatc tatgggctgt agcagtacac tgaattgtac tgtgccaggg atattgagat   4020

gctctggggg tatattgtat acctgccagt tttcttcatt tctgaattga gttttctttt   4080

cttgatgttg gtttccttca tatcacctca aggtttagat ttgtgaagga ataagcatga   4140

tggaaataat agtcttgaaa ggagatatgt tgtatataat caggaggaag aggaaggaag   4200

gacttaccca ttttgatatt ttgctgtagg tggccagttt tgtttctcat agggaaatct   4260

gacccccacc tgtcatgttg gctcctaagg aactgctgtt gtaagcggct catcaagagt   4320

tgaacttcac gtagccttgt tgggaatatg gaaaaggaag aaagccacag gactgcccat   4380

tcagtcttgt taagattggg atgattctgc acaagcaaaa atgacttgaa atttatgtat   4440

cgacacacct ctaccaatcc atcttcagct gactgaatgt tgtatgatag cccttctcca   4500

aagcaggggt agaatgttca ggtttcacca cggattttct acttatttcg cttttggaat   4560

cagcttacag attccaggtc ccttttgtag atattcttta ttcttttgct tttttaaaaa   4620

ataaactggt attagtcaat gtttcgtgtt ccgcattatt tgaaccattt gcccttacag   4680

aaagagaaat acttgtttgt gttttaaata aaactgatgt aggata                  4726


<210>  364
<211>  805
<212>  PRT
<213>  Homo sapiens

<400>  364

Met Pro Asn Gln Gly Glu Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys 
1               5                   10                  15


Thr Lys Gly Asp Ser Cys Pro Phe Arg His Cys Glu Ala Ala Leu Gly 
            20                  25                  30


Asn Glu Thr Val Cys Thr Leu Trp Gln Glu Gly Arg Cys Phe Arg Arg 
        35                  40                  45


Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile 
    50                  55                  60


Pro Cys Tyr Trp Glu Asn Gln Pro Thr Gly Cys Gln Lys Leu Asn Cys 
65                  70                  75                  80


Ala Phe His His Asn Arg Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro 
                85                  90                  95


Pro Ser Lys Ser Val Leu Pro Thr Val Pro Glu Ser Pro Glu Glu Glu 
            100                 105                 110


Val Lys Ala Ser Gln Leu Ser Val Gln Gln Asn Lys Leu Ser Val Gln 
        115                 120                 125


Ser Asn Pro Ser Pro Gln Leu Arg Ser Val Met Lys Val Glu Ser Ser 
    130                 135                 140


Glu Asn Val Pro Ser Pro Lys His Pro Pro Val Val Ile Asn Ala Ala 
145                 150                 155                 160


Asp Asp Asp Glu Asp Asp Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu 
                165                 170                 175


Thr Lys Thr Pro Thr Leu Gln Pro Thr Pro Glu Val His Asn Gly Leu 
            180                 185                 190


Arg Val Thr Ser Val Arg Lys Pro Ala Val Asn Ile Lys Gln Gly Glu 
        195                 200                 205


Cys Leu His Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys 
    210                 215                 220


Met Lys Glu Lys Ser Glu Glu Gln Gly Glu Gly Ser Ser Gly Val Ser 
225                 230                 235                 240


Ser Leu Leu Leu His Pro Glu Pro Val Pro Gly Pro Glu Lys Glu Asn 
                245                 250                 255


Val Arg Thr Val Val Arg Thr Val Thr Leu Ser Thr Lys Gln Gly Glu 
            260                 265                 270


Glu Pro Leu Val Arg Leu Gly Leu Thr Glu Thr Leu Gly Lys Arg Lys 
        275                 280                 285


Phe Ser Thr Gly Gly Asp Ser Asp Pro Pro Leu Lys Arg Ser Leu Ala 
    290                 295                 300


Gln Arg Leu Gly Lys Lys Val Glu Ala Pro Glu Thr Asn Thr Asp Glu 
305                 310                 315                 320


Thr Pro Lys Lys Ala Gln Val Ser Lys Ser Leu Lys Glu Arg Leu Gly 
                325                 330                 335


Met Ser Ala Asp Pro Asn Asn Glu Asp Ala Thr Asp Lys Val Asn Lys 
            340                 345                 350


Val Gly Glu Ile His Val Lys Thr Leu Glu Glu Met Leu Leu Glu Arg 
        355                 360                 365


Ala Ser Gln Lys His Gly Glu Ser Gln Thr Lys Leu Lys Thr Glu Gly 
    370                 375                 380


Pro Ser Lys Thr Asp Asp Ser Thr Ser Gly Ala Arg Ser Ser Ser Thr 
385                 390                 395                 400


Ile Arg Ile Lys Thr Phe Ser Glu Val Leu Ala Glu Glu Glu His Arg 
                405                 410                 415


Gln Gln Glu Ala Glu Arg Gln Lys Ser Lys Lys Asp Thr Thr Cys Ile 
            420                 425                 430


Lys Leu Lys Thr Asp Ser Glu Ile Lys Lys Thr Val Val Leu Pro Pro 
        435                 440                 445


Ile Val Ala Ser Lys Gly Gln Ser Glu Glu Pro Ala Gly Lys Thr Lys 
    450                 455                 460


Ser Met Gln Glu Val His Met Lys Thr Val Glu Glu Ile Lys Leu Glu 
465                 470                 475                 480


Lys Ala Leu Arg Val Gln Gln Ser Ser Glu Ser Ser Thr Ser Ser Pro 
                485                 490                 495


Ser Gln His Glu Ala Thr Pro Gly Ala Arg Leu Leu Leu Arg Ile Thr 
            500                 505                 510


Lys Arg Thr Trp Arg Lys Glu Glu Lys Lys Leu Gln Glu Gly Asn Glu 
        515                 520                 525


Val Asp Phe Leu Ser Arg Val Arg Met Glu Ala Thr Glu Ala Ser Val 
    530                 535                 540


Glu Thr Thr Gly Val Asp Ile Thr Lys Ile Gln Val Lys Arg Cys Glu 
545                 550                 555                 560


Ile Met Arg Glu Thr Arg Met Gln Lys Gln Gln Glu Arg Glu Lys Ser 
                565                 570                 575


Val Leu Thr Pro Leu Gln Gly Asp Val Ala Ser Cys Asn Thr Gln Val 
            580                 585                 590


Ala Glu Lys Pro Val Leu Thr Ala Val Pro Gly Ile Thr Trp His Leu 
        595                 600                 605


Thr Lys Gln Leu Pro Thr Lys Ser Ser Gln Lys Val Glu Val Glu Thr 
    610                 615                 620


Ser Gly Ile Ala Asp Ser Leu Leu Asn Val Lys Trp Ser Ala Gln Thr 
625                 630                 635                 640


Leu Glu Lys Arg Gly Glu Ala Lys Pro Thr Val Asn Val Lys Gln Ser 
                645                 650                 655


Val Val Lys Val Val Ser Ser Pro Lys Leu Ala Pro Lys Arg Lys Ala 
            660                 665                 670


Val Glu Met His Pro Ala Val Thr Ala Ala Val Lys Pro Leu Ser Ser 
        675                 680                 685


Ser Ser Val Leu Gln Glu Pro Pro Ala Lys Lys Ala Ala Val Asp Ala 
    690                 695                 700


Val Val Leu Leu Val Ser Glu Asp Lys Ser Val Thr Val Pro Glu Thr 
705                 710                 715                 720


Glu Asn Pro Arg Asp Ser Leu Val Leu Pro Leu Thr Gln Ser Ser Ser 
                725                 730                 735


Asp Ser Ser Pro Pro Glu Val Ser Gly Pro Ser Ser Ser Gln Met Ser 
            740                 745                 750


Met Lys Thr Arg Arg Leu Ser Ser Ala Ser Thr Gly Lys Pro Pro Leu 
        755                 760                 765


Ser Val Glu Asp Asp Phe Glu Lys Leu Thr Trp Glu Ile Ser Gly Gly 
    770                 775                 780


Lys Leu Glu Ala Glu Ile Asp Leu Asp Pro Gly Lys Asp Glu Asp Asp 
785                 790                 795                 800


Leu Pro Leu Glu Leu 
                805


<210>  365
<211>  5197
<212>  DNA
<213>  Homo sapiens

<400>  365
agaaccctcg cgccctgcgt cgtgctggca cttttaccgg ccgggcctta gagcgcagcc     60

tgtagccggg cgccatcttt gacgctggca gtcttggttt tctgctagtg ctgctgctgc    120

tgggaggacg acggacggca gcggccaagc gagaagaaag acgtggcagc aagcgggagt    180

cggggatagt gtcatcggtt cgggtcccac tactttggag cttgtctcaa actccacata    240

cagaaagcca ccgaccttat tccggtatcc tacacccatt ccccaccctc attacactcc    300

cacccctggc cctcagcgtg ggagtcaaga gcaacaggga cacttccgta ctccttgtag    360

gattggtgaa accgtaatga cgaacacccc taaactccca taattggtgc ggattcctgt    420

ggggaaggcc tatactgttg acatcttcca ggccatctca aggttctgga ccttgagaag    480

gaggctgtgg aactagagat agtgatgctt tttaggattt ggggatattc cctgcccaaa    540

aaattcctgg aaaattgact agtattaagt ctatggaaga tggatttttt ttcatgatcc    600

tttgactctc aagttcatct ttaaatgaac tctttttttt gttttgtttt tgaggagata    660

actaacccta gctgtctcca gtctgacaaa ggttatttga atggacttaa tctcccagta    720

gttgggagat gttttaaaaa cacatgctgt gtttgaattg tggctgagag gttttcttgg    780

caatgtgagg aggaaaattt tttctgcttc attattatta attcatggat tgagtgttgg    840

ttcgacctac aggcgtaata gattggaact cagtgaagac acagacgttc ctgttgagag    900

caatcagcta atgattacag tttaaagaca atttctgtga tcaagttgtc atttggaaga    960

ttaaacccat ttcacgagga cttggagcct ggtccttgct ttgaggaagc agtggcttgt   1020

ttcaagaagc cacttctgat ctaagaatct acccagcatg cctaatcaag gagaagactg   1080

ctattttttt ttctattcta catgtaccaa aggtgacagc tgcccattcc gtcactgtga   1140

agctgcacta ggcaatgaaa ctgtttgcac attatggcaa gaagggcgct gttttcgacg   1200

ggtgtgcagg tttcggcaca tggagattga taaaaaacgc agtgaaattc cttgttattg   1260

ggaaaatcag ccaacaggat gtcaaaaatt aaactgcgct ttccatcaca atagaggacg   1320

atatgttgat ggccttttcc tacctccgag caaaagtgtg ttgcccactg tgcctgagtc   1380

accagaagag gaagtgaagg ctagccaact ttcagttcag cagaacaaat tgtctgtcca   1440

gtccaatcct tcccctcagc tgcggagcgt tatgaaagta gaaagttccg aaaatgttcc   1500

tagccccaag catccaccag ttgtaattaa tgctgcagat gatgatgaag atgatgatga   1560

tcagttttct gaggaaggtg atgaaaccaa aacacctacc ctgcaaccaa ctcctgaagt   1620

tcacaatgga ttacgagtga cttctgtccg gaaacctgca gtcaatataa agcaaggtga   1680

atgtttgcat tttggaataa aaactcttga ggaaattaag tcaaagaaaa tgaaggaaaa   1740

atctgaggag caaggtgagg gttcttcagg agtttccagt cttttactcc accctgagcc   1800

tgttccaggt cctgaaaaag aaaatgtcag gactgtggtg aggacagtaa ctctctccac   1860

caaacaagga gaagaaccct tggttagatt gggccttact gagacactgg ggaaacgaaa   1920

attttcgaca ggcggtgaca gtgatcctcc attaaagcgc agcctggcac agaggctagg   1980

gaagaaagtt gaagctccag aaactaacac tgacgaaaca ccaaagaaag ctcaagtttc   2040

caagtctctt aaggagcgat taggcatgtc agctgatcca aataatgagg acgcaacaga   2100

taaagttaat aaagttggtg agatccatgt gaagacatta gaagaaatgc ttcttgaaag   2160

agccagtcag aaacatgggg aatcgcaaac taaactcaag acagaaggac cttcaaaaac   2220

tgatgattct acttcaggag caagaagctc ctccactatc cgtatcaaaa ccttctctga   2280

ggtcctggct gaagaagaac ataggcagca ggaagcagag agacaaaaaa gcaaaaagga   2340

tacaacttgc atcaagctaa agactgatag tgaaattaaa aaaacagtag ttttgccacc   2400

cattgttgcc agcaaaggac aatcagagga gcctgcaggt aaaacaaagt ccatgcagga   2460

ggtgcacatg aagacggtgg aagaaattaa actggagaag gcactgaggg tgcagcagag   2520

ctctgagagc agcaccagct ccccgtctca acatgaggcc actccagggg caaggttgct   2580

actgcgaatc accaaaagaa catggaggaa agaagagaag aaacttcagg aaggaaatga   2640

agttgatttt ctgagccgtg ttagaatgga agctacagag gcttcagttg agaccacagg   2700

agttgacatc actaaaattc aagtcaagag atgtgagatc atgagagaga cgcgcatgca   2760

gaaacagcag gagagggaaa aatcagtctt gacacctctt cagggagatg tagcctcttg   2820

caatacccaa gtggcagaga aaccagtgct cactgctgtg ccaggaatca catggcacct   2880

gaccaagcag cttcccacaa agtcatccca gaaggtggag gtagaaacct cagggattgc   2940

agactcatta ttgaatgtga aatggtcagc acagaccttg gaaaaaaggg gtgaagctaa   3000

acccacagtg aacgtgaagc aatctgtggt taaagttgtg tcatccccca aattggcccc   3060

aaaacgtaag gcagtggaga tgcaccctgc tgtcactgcc gctgtgaagc cactcagctc   3120

cagcagcgtc ctacaggaac ccccagccaa aaaggcagct gtggatgctg ttgtcctgct   3180

tgtctctgag gacaaatcag tcactgtgcc tgaaacagaa aatcctagag acagtcttgt   3240

gctgcctcta acccagtcct cttcagattc ctcacccccg gaggtgtctg gcccttcctc   3300

atcccaaatg agcatgaaaa ctcgccgact cagctctgcc tcaacaggaa agcccccact   3360

ctctgtggag gatgattttg agaaactaac atgggagatt tcaggaggca aattggaagc   3420

tgagattgac ctggatcctg ggaaagatga agatgacctt ccgcttgagc tatgagaaat   3480

gattgatagc tgaaggtggt agtgaggaca ctttaaaaaa aaatcgccaa aaaactggac   3540

ttagtttcat ctattgtaac atttacctga gatgatcatt tctttagtct agaatttgcc   3600

ccaaatcaga agtatacctc tgaattatct gtatgtgtcc tggattcctt ggggtcagat   3660

ttttaaagtt actttataac cattttgtcc atttgatgcc attgtttatc atcttttgag   3720

aaaaaagttc tgtcataccc ttctctccac aaaaaagaga ctgagaggga gatcaagtga   3780

aagggtgcaa gcaaacttag tgactccttg aggtgtttgt cagttttggc ttttttctcc   3840

tttgttgtat tctttatgta ttgtcttgat gtacttaata ttacctgagt ttgaaatgga   3900

tgaagacagc tgctaccatt aaggaccaaa ttttatgcta ccactaaaca aaaataccca   3960

ctcagtctgt gttagattgt atgtcttttt aaaggtattt agagattcaa ctaagcttta   4020

aagagggctg agcagctcag gaagcctgta atgtgggcat aactctttgg acctgatctt   4080

gatgcttctg ctgctctgtt ggcctctgaa gagcaatatc taatttatta ttactgtaat   4140

tttttaaaag gctttaaagt gcctcagggg tcccctgaaa ctaattttct atttctggga   4200

ttccctggat tcattatatg agatggtgac atgattagag gaattctttt ttagtatgaa   4260

aattgtccct tttcttcttc agtacttgcc tccttgctgg cattgaatta acacagggac   4320

aaaatatggt taatttttta tttctaattc tcccaacaaa cccctgttgc ccagtattta   4380

tgtggtggcc tttaaccacc tgagggaaaa aatgagctta ttcaagctgc caatatttat   4440

ctatgggctg tagcagtaca ctgaattgta ctgtgccagg gatattgaga tgctctgggg   4500

gtatattgta tacctgccag ttttcttcat ttctgaattg agttttcttt tcttgatgtt   4560

ggtttccttc atatcacctc aaggtttaga tttgtgaagg aataagcatg atggaaataa   4620

tagtcttgaa aggagatatg ttgtatataa tcaggaggaa gaggaaggaa ggacttaccc   4680

attttgatat tttgctgtag gtggccagtt ttgtttctca tagggaaatc tgacccccac   4740

ctgtcatgtt ggctcctaag gaactgctgt tgtaagcggc tcatcaagag ttgaacttca   4800

cgtagccttg ttgggaatat ggaaaaggaa gaaagccaca ggactgccca ttcagtcttg   4860

ttaagattgg gatgattctg cacaagcaaa aatgacttga aatttatgta tcgacacacc   4920

tctaccaatc catcttcagc tgactgaatg ttgtatgata gcccttctcc aaagcagggg   4980

tagaatgttc aggtttcacc acggattttc tacttatttc gcttttggaa tcagcttaca   5040

gattccaggt cccttttgta gatattcttt attcttttgc ttttttaaaa aataaactgg   5100

tattagtcaa tgtttcgtgt tccgcattat ttgaaccatt tgcccttaca gaaagagaaa   5160

tacttgtttg tgttttaaat aaaactgatg taggata                            5197


<210>  366
<211>  805
<212>  PRT
<213>  Homo sapiens

<400>  366

Met Pro Asn Gln Gly Glu Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys 
1               5                   10                  15


Thr Lys Gly Asp Ser Cys Pro Phe Arg His Cys Glu Ala Ala Leu Gly 
            20                  25                  30


Asn Glu Thr Val Cys Thr Leu Trp Gln Glu Gly Arg Cys Phe Arg Arg 
        35                  40                  45


Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile 
    50                  55                  60


Pro Cys Tyr Trp Glu Asn Gln Pro Thr Gly Cys Gln Lys Leu Asn Cys 
65                  70                  75                  80


Ala Phe His His Asn Arg Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro 
                85                  90                  95


Pro Ser Lys Ser Val Leu Pro Thr Val Pro Glu Ser Pro Glu Glu Glu 
            100                 105                 110


Val Lys Ala Ser Gln Leu Ser Val Gln Gln Asn Lys Leu Ser Val Gln 
        115                 120                 125


Ser Asn Pro Ser Pro Gln Leu Arg Ser Val Met Lys Val Glu Ser Ser 
    130                 135                 140


Glu Asn Val Pro Ser Pro Lys His Pro Pro Val Val Ile Asn Ala Ala 
145                 150                 155                 160


Asp Asp Asp Glu Asp Asp Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu 
                165                 170                 175


Thr Lys Thr Pro Thr Leu Gln Pro Thr Pro Glu Val His Asn Gly Leu 
            180                 185                 190


Arg Val Thr Ser Val Arg Lys Pro Ala Val Asn Ile Lys Gln Gly Glu 
        195                 200                 205


Cys Leu His Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys 
    210                 215                 220


Met Lys Glu Lys Ser Glu Glu Gln Gly Glu Gly Ser Ser Gly Val Ser 
225                 230                 235                 240


Ser Leu Leu Leu His Pro Glu Pro Val Pro Gly Pro Glu Lys Glu Asn 
                245                 250                 255


Val Arg Thr Val Val Arg Thr Val Thr Leu Ser Thr Lys Gln Gly Glu 
            260                 265                 270


Glu Pro Leu Val Arg Leu Gly Leu Thr Glu Thr Leu Gly Lys Arg Lys 
        275                 280                 285


Phe Ser Thr Gly Gly Asp Ser Asp Pro Pro Leu Lys Arg Ser Leu Ala 
    290                 295                 300


Gln Arg Leu Gly Lys Lys Val Glu Ala Pro Glu Thr Asn Thr Asp Glu 
305                 310                 315                 320


Thr Pro Lys Lys Ala Gln Val Ser Lys Ser Leu Lys Glu Arg Leu Gly 
                325                 330                 335


Met Ser Ala Asp Pro Asn Asn Glu Asp Ala Thr Asp Lys Val Asn Lys 
            340                 345                 350


Val Gly Glu Ile His Val Lys Thr Leu Glu Glu Met Leu Leu Glu Arg 
        355                 360                 365


Ala Ser Gln Lys His Gly Glu Ser Gln Thr Lys Leu Lys Thr Glu Gly 
    370                 375                 380


Pro Ser Lys Thr Asp Asp Ser Thr Ser Gly Ala Arg Ser Ser Ser Thr 
385                 390                 395                 400


Ile Arg Ile Lys Thr Phe Ser Glu Val Leu Ala Glu Glu Glu His Arg 
                405                 410                 415


Gln Gln Glu Ala Glu Arg Gln Lys Ser Lys Lys Asp Thr Thr Cys Ile 
            420                 425                 430


Lys Leu Lys Thr Asp Ser Glu Ile Lys Lys Thr Val Val Leu Pro Pro 
        435                 440                 445


Ile Val Ala Ser Lys Gly Gln Ser Glu Glu Pro Ala Gly Lys Thr Lys 
    450                 455                 460


Ser Met Gln Glu Val His Met Lys Thr Val Glu Glu Ile Lys Leu Glu 
465                 470                 475                 480


Lys Ala Leu Arg Val Gln Gln Ser Ser Glu Ser Ser Thr Ser Ser Pro 
                485                 490                 495


Ser Gln His Glu Ala Thr Pro Gly Ala Arg Leu Leu Leu Arg Ile Thr 
            500                 505                 510


Lys Arg Thr Trp Arg Lys Glu Glu Lys Lys Leu Gln Glu Gly Asn Glu 
        515                 520                 525


Val Asp Phe Leu Ser Arg Val Arg Met Glu Ala Thr Glu Ala Ser Val 
    530                 535                 540


Glu Thr Thr Gly Val Asp Ile Thr Lys Ile Gln Val Lys Arg Cys Glu 
545                 550                 555                 560


Ile Met Arg Glu Thr Arg Met Gln Lys Gln Gln Glu Arg Glu Lys Ser 
                565                 570                 575


Val Leu Thr Pro Leu Gln Gly Asp Val Ala Ser Cys Asn Thr Gln Val 
            580                 585                 590


Ala Glu Lys Pro Val Leu Thr Ala Val Pro Gly Ile Thr Trp His Leu 
        595                 600                 605


Thr Lys Gln Leu Pro Thr Lys Ser Ser Gln Lys Val Glu Val Glu Thr 
    610                 615                 620


Ser Gly Ile Ala Asp Ser Leu Leu Asn Val Lys Trp Ser Ala Gln Thr 
625                 630                 635                 640


Leu Glu Lys Arg Gly Glu Ala Lys Pro Thr Val Asn Val Lys Gln Ser 
                645                 650                 655


Val Val Lys Val Val Ser Ser Pro Lys Leu Ala Pro Lys Arg Lys Ala 
            660                 665                 670


Val Glu Met His Pro Ala Val Thr Ala Ala Val Lys Pro Leu Ser Ser 
        675                 680                 685


Ser Ser Val Leu Gln Glu Pro Pro Ala Lys Lys Ala Ala Val Asp Ala 
    690                 695                 700


Val Val Leu Leu Val Ser Glu Asp Lys Ser Val Thr Val Pro Glu Thr 
705                 710                 715                 720


Glu Asn Pro Arg Asp Ser Leu Val Leu Pro Leu Thr Gln Ser Ser Ser 
                725                 730                 735


Asp Ser Ser Pro Pro Glu Val Ser Gly Pro Ser Ser Ser Gln Met Ser 
            740                 745                 750


Met Lys Thr Arg Arg Leu Ser Ser Ala Ser Thr Gly Lys Pro Pro Leu 
        755                 760                 765


Ser Val Glu Asp Asp Phe Glu Lys Leu Thr Trp Glu Ile Ser Gly Gly 
    770                 775                 780


Lys Leu Glu Ala Glu Ile Asp Leu Asp Pro Gly Lys Asp Glu Asp Asp 
785                 790                 795                 800


Leu Pro Leu Glu Leu 
                805


<210>  367
<211>  2245
<212>  DNA
<213>  Homo sapiens

<400>  367
caaaattcat atgttgcaac atttaccctt agtgtgacta tatttggaga tagggctttt     60

aggaggtgtt ttttgaaaac taatcagaag aggaatgctt atctcccaag aaaattgaaa    120

ccatctgtaa aagaatcttg gctgtgctgt gttttgatta gattgaagct tggtgtaaag    180

agaaaacaca aaagaccgca gaatatttac aacatttgaa ttcctgtttc tccatcaaag    240

cacattgtca tcaaagctac tttgggtata gaaaaaaggt caattccaat tcccaggaat    300

ccttaaccac aactttactt ggaaatttcc ggtaatactt aaaacaccat tttgcagcaa    360

ttctttatga taaactgtaa aatacagcta cccgaaaatg actgacaaat caatcgtcat    420

tctgagcctg atggtttttc acagctcttt cataaatgga aaaacatgta gacggcaatt    480

ggtggaagaa tggcatccac aaccctcatc atatgtggta aattggacac taacagaaaa    540

catctgcttg gacttctaca gagattgctg gtttttgggt gtaaacacta aaatagatac    600

ttcaggcaat caagctgttc cccagatttg ccctttgcaa attcaattag gagatatcct    660

tgtaatttct tctgaaccat ctcttcaatt tccagaaata aatttgatga atgtttctga    720

aacatctttc gttggctgtg tgcaaaatac cacaacggaa gatcagttac tttttggctg    780

cagactaaaa ggaatgcaca ctgttaattc taagtggctg agtgttggga cacattattt    840

tatcacagtt atggcaagtg gtccatcacc ttgtccactg ggacttcgac taaatgtgac    900

agtgaaacag cagttctgcc aggaatctct gagttcagaa ttttgctctg gtcatggtaa    960

atgtcttagt gaagcttgga gcaagacata tagctgccat tgccagcctc cattttctgg   1020

aaaatactgc caggaacttg atgcatgttc ttttaaacca tgtaaaaata atggcagttg   1080

cattaataaa agagaaaatt gggatgagca agcatatgaa tgtgtctgtc acccaccatt   1140

tacaggaaag aattgctcag aaataattgg ccagtgtcaa ccacatgtct gtttccatgg   1200

aaactgcagc aatattactt caaatagttt catttgtgaa tgtgatgagc aattttcagg   1260

tccattctgt gaggtgtcag caaaaccttg tgtttctctg cttttttgga aaagaggaat   1320

ttgcccaaat agcagttctg cttatactta tgaatgccca aaaggatctt ccagccaaaa   1380

tggtgaaact gatgtcagtg agttttcatt agtaccatgt cagaatggta ctgactgcat   1440

caaaatatca aatgatgtta tgtgcatctg ttcaccaata tttacagatt tgctttgtaa   1500

gagcattcaa acatcatgtg agtcatttcc tttgaggaat aatgctacat gtaagaaatg   1560

tgagaaagat tatccttgca gctgtatatc aggatttact gaaaaaaact gtgagaaagc   1620

aattgaccac tgtaaactgc tcagcatcaa ctgtctgaat gaagaatggt gtttcaatat   1680

aattggaaga ttcaaatatg tatgcattcc agggtgcaca aaaaatccat gttggttttt   1740

gaagaatgtt tacctaattc atcaacacct ctgctactgt ggagtcacct tccatggtat   1800

ttgccaagat aaaggtcctg ctcaatttga atatgtgtgg caattgggat ttgcaggatc   1860

tgaaggcgaa aagtgccaag gggttattga tgcctatttc tttctggctg caaactgcac   1920

tgaagatgca acctatgtga acgatcctga agataataat tcttcatgtt ggttcccaca   1980

tgaaggcaca aaagagattt gtgcaaatgg atgcagttgt ttgagtgaag aagacagtca   2040

ggaatatcgg tatctatgtt ttctcagatg ggctggcaac atgtatctgg aaaatacaac   2100

tgatgatcaa gaaaatgagt gtcaacatga agctgtttgt aaagatgaaa ttaatagacc   2160

caggtattta tgtatcattt gagcagataa tatcacatat caaaaagtta taattaaatt   2220

gatagtcatc aaaaaaaaaa aaaaa                                         2245


<210>  368
<211>  594
<212>  PRT
<213>  Homo sapiens

<400>  368

Met Thr Asp Lys Ser Ile Val Ile Leu Ser Leu Met Val Phe His Ser 
1               5                   10                  15


Ser Phe Ile Asn Gly Lys Thr Cys Arg Arg Gln Leu Val Glu Glu Trp 
            20                  25                  30


His Pro Gln Pro Ser Ser Tyr Val Val Asn Trp Thr Leu Thr Glu Asn 
        35                  40                  45


Ile Cys Leu Asp Phe Tyr Arg Asp Cys Trp Phe Leu Gly Val Asn Thr 
    50                  55                  60


Lys Ile Asp Thr Ser Gly Asn Gln Ala Val Pro Gln Ile Cys Pro Leu 
65                  70                  75                  80


Gln Ile Gln Leu Gly Asp Ile Leu Val Ile Ser Ser Glu Pro Ser Leu 
                85                  90                  95


Gln Phe Pro Glu Ile Asn Leu Met Asn Val Ser Glu Thr Ser Phe Val 
            100                 105                 110


Gly Cys Val Gln Asn Thr Thr Thr Glu Asp Gln Leu Leu Phe Gly Cys 
        115                 120                 125


Arg Leu Lys Gly Met His Thr Val Asn Ser Lys Trp Leu Ser Val Gly 
    130                 135                 140


Thr His Tyr Phe Ile Thr Val Met Ala Ser Gly Pro Ser Pro Cys Pro 
145                 150                 155                 160


Leu Gly Leu Arg Leu Asn Val Thr Val Lys Gln Gln Phe Cys Gln Glu 
                165                 170                 175


Ser Leu Ser Ser Glu Phe Cys Ser Gly His Gly Lys Cys Leu Ser Glu 
            180                 185                 190


Ala Trp Ser Lys Thr Tyr Ser Cys His Cys Gln Pro Pro Phe Ser Gly 
        195                 200                 205


Lys Tyr Cys Gln Glu Leu Asp Ala Cys Ser Phe Lys Pro Cys Lys Asn 
    210                 215                 220


Asn Gly Ser Cys Ile Asn Lys Arg Glu Asn Trp Asp Glu Gln Ala Tyr 
225                 230                 235                 240


Glu Cys Val Cys His Pro Pro Phe Thr Gly Lys Asn Cys Ser Glu Ile 
                245                 250                 255


Ile Gly Gln Cys Gln Pro His Val Cys Phe His Gly Asn Cys Ser Asn 
            260                 265                 270


Ile Thr Ser Asn Ser Phe Ile Cys Glu Cys Asp Glu Gln Phe Ser Gly 
        275                 280                 285


Pro Phe Cys Glu Val Ser Ala Lys Pro Cys Val Ser Leu Leu Phe Trp 
    290                 295                 300


Lys Arg Gly Ile Cys Pro Asn Ser Ser Ser Ala Tyr Thr Tyr Glu Cys 
305                 310                 315                 320


Pro Lys Gly Ser Ser Ser Gln Asn Gly Glu Thr Asp Val Ser Glu Phe 
                325                 330                 335


Ser Leu Val Pro Cys Gln Asn Gly Thr Asp Cys Ile Lys Ile Ser Asn 
            340                 345                 350


Asp Val Met Cys Ile Cys Ser Pro Ile Phe Thr Asp Leu Leu Cys Lys 
        355                 360                 365


Ser Ile Gln Thr Ser Cys Glu Ser Phe Pro Leu Arg Asn Asn Ala Thr 
    370                 375                 380


Cys Lys Lys Cys Glu Lys Asp Tyr Pro Cys Ser Cys Ile Ser Gly Phe 
385                 390                 395                 400


Thr Glu Lys Asn Cys Glu Lys Ala Ile Asp His Cys Lys Leu Leu Ser 
                405                 410                 415


Ile Asn Cys Leu Asn Glu Glu Trp Cys Phe Asn Ile Ile Gly Arg Phe 
            420                 425                 430


Lys Tyr Val Cys Ile Pro Gly Cys Thr Lys Asn Pro Cys Trp Phe Leu 
        435                 440                 445


Lys Asn Val Tyr Leu Ile His Gln His Leu Cys Tyr Cys Gly Val Thr 
    450                 455                 460


Phe His Gly Ile Cys Gln Asp Lys Gly Pro Ala Gln Phe Glu Tyr Val 
465                 470                 475                 480


Trp Gln Leu Gly Phe Ala Gly Ser Glu Gly Glu Lys Cys Gln Gly Val 
                485                 490                 495


Ile Asp Ala Tyr Phe Phe Leu Ala Ala Asn Cys Thr Glu Asp Ala Thr 
            500                 505                 510


Tyr Val Asn Asp Pro Glu Asp Asn Asn Ser Ser Cys Trp Phe Pro His 
        515                 520                 525


Glu Gly Thr Lys Glu Ile Cys Ala Asn Gly Cys Ser Cys Leu Ser Glu 
    530                 535                 540


Glu Asp Ser Gln Glu Tyr Arg Tyr Leu Cys Phe Leu Arg Trp Ala Gly 
545                 550                 555                 560


Asn Met Tyr Leu Glu Asn Thr Thr Asp Asp Gln Glu Asn Glu Cys Gln 
                565                 570                 575


His Glu Ala Val Cys Lys Asp Glu Ile Asn Arg Pro Arg Tyr Leu Cys 
            580                 585                 590


Ile Ile 



<210>  369
<211>  531
<212>  DNA
<213>  Homo sapiens

<400>  369
agaaatgcca gacactaatt acaagactga agatttgtga ttattaaagt gataagtttc     60

cagtgacata tacatgaaat gccagcacat agctaatatc actgaccaca tggactgctg    120

gggacatgga ttcctaaatg ctatgtatgt gctcactttc actttaataa gcagcagtac    180

aagtggagga gaagtgtcct ggaagaggaa acctgcactc aagggataga agacgaagcc    240

cagaagagtg gaacaatagg ctaagcttag gacagatggg caaaaaagca tcattgaatg    300

acaaagctga aaaggaactg gatatcaggg atcacaaacc caaatgctta caggggctac    360

cacacggata ttggacaaga ggacttaaga ctctgaaagg taacagcaga aacaacttcc    420

ttccaccctg tgtgtgtcac tgtctacagc agcatggaga agtcaggcga gtgtttccca    480

taaattcagt gggattctta tggtaaccgt gggaagaaga gagtgcagga c             531


<210>  370
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  370

Met Gly Lys Lys Ala Ser Leu Asn Asp Lys Ala Glu Lys Glu Leu Asp 
1               5                   10                  15


Ile Arg Asp His Lys Pro Lys Cys Leu Gln Gly Leu Pro His Gly Tyr 
            20                  25                  30


Trp Thr Arg Gly Leu Lys Thr Leu Lys Gly Asn Ser Arg Asn Asn Phe 
        35                  40                  45


Leu Pro Pro Cys Val Cys His Cys Leu Gln Gln His Gly Glu Val Arg 
    50                  55                  60


Arg Val Phe Pro Ile Asn Ser Val Gly Phe Leu Trp 
65                  70                  75


<210>  371
<211>  522
<212>  DNA
<213>  Homo sapiens

<400>  371
atggtgcccg gcaccatcag cttttgtcct ctgctgcagc taaagtgtct tcctcctgga     60

ccagggagag ggggaggggg tgtggacagg acccgcctgc tgacggtgac acctcttcga    120

caccacgtcc acgccagtcc tcagctccag gagctgggcg ggatccctca tcccgctcag    180

ctgggagatg ccccgggagg gcgtcccccg gctccgggcg gcgagggtag tagccgaccc    240

caatccactc cgggggccgc cgggggccgc gtgaaggcag gtgttccggg gagaaacgtg    300

gaagggaggc gcggcctggg gccggtggcg ctcggctggg ggccgcagtt ggctcccctg    360

ggggctctgg gcggcggcag ctcccgcctg tggggaggag aaggagccgg atgggcgggt    420

tcaggcgcgc gcggcggcgg tcccggggcc gccggctcct ccccgcgagg gtgcctgtcc    480

gccgctcgcc gcgctgaggc agtgcggggc gggcgcgcct ag                       522


<210>  372
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  372

Met Val Pro Gly Thr Ile Ser Phe Cys Pro Leu Leu Gln Leu Lys Cys 
1               5                   10                  15


Leu Pro Pro Gly Pro Gly Arg Gly Gly Gly Gly Val Asp Arg Thr Arg 
            20                  25                  30


Leu Leu Thr Val Thr Pro Leu Arg His His Val His Ala Ser Pro Gln 
        35                  40                  45


Leu Gln Glu Leu Gly Gly Ile Pro His Pro Ala Gln Leu Gly Asp Ala 
    50                  55                  60


Pro Gly Gly Arg Pro Pro Ala Pro Gly Gly Glu Gly Ser Ser Arg Pro 
65                  70                  75                  80


Gln Ser Thr Pro Gly Ala Ala Gly Gly Arg Val Lys Ala Gly Val Pro 
                85                  90                  95


Gly Arg Asn Val Glu Gly Arg Arg Gly Leu Gly Pro Val Ala Leu Gly 
            100                 105                 110


Trp Gly Pro Gln Leu Ala Pro Leu Gly Ala Leu Gly Gly Gly Ser Ser 
        115                 120                 125


Arg Leu Trp Gly Gly Glu Gly Ala Gly Trp Ala Gly Ser Gly Ala Arg 
    130                 135                 140


Gly Gly Gly Pro Gly Ala Ala Gly Ser Ser Pro Arg Gly Cys Leu Ser 
145                 150                 155                 160


Ala Ala Arg Arg Ala Glu Ala Val Arg Gly Gly Arg Ala 
                165                 170


<210>  373
<211>  1755
<212>  DNA
<213>  Homo sapiens

<400>  373
cgcgagggtg cctgtccgcc gctcgccgcg ctgaggcagt gcggggcggg cgcgcctagg     60

ctgccgccca gcgccctcgc cgcggccatg cccgggccct agagcgcctg ccgcagcttg    120

cgccccgcag ccccgcagcc ccgcgcccgc cgccgcctct tcaatgggca acctgctcgg    180

cggggtcagc ttccgcgagc ccaccaccgt ggaggactgc gactccacct ggcagaccga    240

ctcggagccc gagcccgaag aaccagggcc gggcggcggc agcgagggcc cggggcagga    300

gtccgagcag cccgcgcagc ccccggagca agccggcggg cggcccggcg ccagccccgc    360

gccggacgag gacgccgagg cggcgggcgc cgagcagggt ggtgattcca ctgaagcaac    420

tgccaaacca aagagaagtt tttatgctgc cagggatttg tacaagtacc gacaccagta    480

cccaaacttc aaagatatcc gatatcaaaa tgacttgagc aatcttcgtt tttataagaa    540

taaaattcca ttcaagccag atggtgttta cattgaagaa gttctaagta aatggaaagg    600

agattatgaa aaactggagc acaaccacac ttacattcaa tggcttttcc ccctgagaga    660

acaaggcttg aacttctatg ccaaagaact aactacatat gaaattgagg aattcaaaaa    720

aacaaaagaa gcaattagaa gattcctcct ggcttataaa atgatgctag aattttttgg    780

aataaaactg actgataaaa ctggaaatgt tgctcgggct gttaactggc aggaaagatt    840

tcagcatctg aatgagtccc agcacaacta tttaagaatc actcgtattc ttaaaagcct    900

tggtgagctt ggatatgaaa gttttaaatc tcctcttgta aaatttattc ttcatgaagc    960

tcttgtggag aatactattc ccaatattaa gcagagtgct ctagagtatt ttgtttatac   1020

aattagagac agaagagaaa ggagaaagct cctgcggttc gcccagaaac actacacgcc   1080

ttcagagaac tttatctggg gaccgcctcg aaaagaacag tcggagggaa gcaaagccca   1140

gaaaatgtct tcccctctcg cctccagtca taacagtcaa acttctatgc acaaaaaagc   1200

caaggactcc aaaaattcct cctcagctgt tcatttaaat agcaaaacag ctgaagacaa   1260

aaaagtggca ccaaaagagc ctgtggaaga gacagacagg cccagcccag agcccagcaa   1320

tgaagctgcc aagccaagaa atacagagaa ggacagtaat gctgagaaca tgaattctca   1380

acctgagaaa acagttacta ctcccacaga aaaaaaggag agtgtatctc ctgagaataa   1440

cgaagaaggt ggaaatgata accaagacaa tgaaaatcct ggaaatacaa attgccatga   1500

tgttgtacta gtacagtgaa ttatcagaaa acccagaagc cagtttaggc tagagaggaa   1560

aaaactactg tatcatttat cctaaagaac agagatgagg tcaatttcaa attttagcca   1620

tctgtttgtg atttctgtca taagcatttt gttgtttgtt tttttatttt ggatgacaat   1680

gaattgaata tctaataagg agatttaaga taagacccaa taaatgaatg tattctgtaa   1740

aaaaaaaaaa aaaaa                                                    1755


<210>  374
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  374

Met Gly Asn Leu Leu Gly Gly Val Ser Phe Arg Glu Pro Thr Thr Val 
1               5                   10                  15


Glu Asp Cys Asp Ser Thr Trp Gln Thr Asp Ser Glu Pro Glu Pro Glu 
            20                  25                  30


Glu Pro Gly Pro Gly Gly Gly Ser Glu Gly Pro Gly Gln Glu Ser Glu 
        35                  40                  45


Gln Pro Ala Gln Pro Pro Glu Gln Ala Gly Gly Arg Pro Gly Ala Ser 
    50                  55                  60


Pro Ala Pro Asp Glu Asp Ala Glu Ala Ala Gly Ala Glu Gln Gly Gly 
65                  70                  75                  80


Asp Ser Thr Glu Ala Thr Ala Lys Pro Lys Arg Ser Phe Tyr Ala Ala 
                85                  90                  95


Arg Asp Leu Tyr Lys Tyr Arg His Gln Tyr Pro Asn Phe Lys Asp Ile 
            100                 105                 110


Arg Tyr Gln Asn Asp Leu Ser Asn Leu Arg Phe Tyr Lys Asn Lys Ile 
        115                 120                 125


Pro Phe Lys Pro Asp Gly Val Tyr Ile Glu Glu Val Leu Ser Lys Trp 
    130                 135                 140


Lys Gly Asp Tyr Glu Lys Leu Glu His Asn His Thr Tyr Ile Gln Trp 
145                 150                 155                 160


Leu Phe Pro Leu Arg Glu Gln Gly Leu Asn Phe Tyr Ala Lys Glu Leu 
                165                 170                 175


Thr Thr Tyr Glu Ile Glu Glu Phe Lys Lys Thr Lys Glu Ala Ile Arg 
            180                 185                 190


Arg Phe Leu Leu Ala Tyr Lys Met Met Leu Glu Phe Phe Gly Ile Lys 
        195                 200                 205


Leu Thr Asp Lys Thr Gly Asn Val Ala Arg Ala Val Asn Trp Gln Glu 
    210                 215                 220


Arg Phe Gln His Leu Asn Glu Ser Gln His Asn Tyr Leu Arg Ile Thr 
225                 230                 235                 240


Arg Ile Leu Lys Ser Leu Gly Glu Leu Gly Tyr Glu Ser Phe Lys Ser 
                245                 250                 255


Pro Leu Val Lys Phe Ile Leu His Glu Ala Leu Val Glu Asn Thr Ile 
            260                 265                 270


Pro Asn Ile Lys Gln Ser Ala Leu Glu Tyr Phe Val Tyr Thr Ile Arg 
        275                 280                 285


Asp Arg Arg Glu Arg Arg Lys Leu Leu Arg Phe Ala Gln Lys His Tyr 
    290                 295                 300


Thr Pro Ser Glu Asn Phe Ile Trp Gly Pro Pro Arg Lys Glu Gln Ser 
305                 310                 315                 320


Glu Gly Ser Lys Ala Gln Lys Met Ser Ser Pro Leu Ala Ser Ser His 
                325                 330                 335


Asn Ser Gln Thr Ser Met His Lys Lys Ala Lys Asp Ser Lys Asn Ser 
            340                 345                 350


Ser Ser Ala Val His Leu Asn Ser Lys Thr Ala Glu Asp Lys Lys Val 
        355                 360                 365


Ala Pro Lys Glu Pro Val Glu Glu Thr Asp Arg Pro Ser Pro Glu Pro 
    370                 375                 380


Ser Asn Glu Ala Ala Lys Pro Arg Asn Thr Glu Lys Asp Ser Asn Ala 
385                 390                 395                 400


Glu Asn Met Asn Ser Gln Pro Glu Lys Thr Val Thr Thr Pro Thr Glu 
                405                 410                 415


Lys Lys Glu Ser Val Ser Pro Glu Asn Asn Glu Glu Gly Gly Asn Asp 
            420                 425                 430


Asn Gln Asp Asn Glu Asn Pro Gly Asn Thr Asn Cys His Asp Val Val 
        435                 440                 445


Leu Val Gln 
    450


<210>  375
<211>  2034
<212>  DNA
<213>  Homo sapiens

<400>  375
cacaaagagc ggggcggaga ggcagctgcg gggggagccg gcggccgctg ctgccgccca     60

gggctctggg gccccgccgg ccaggcccgc cgtccgcggc cagtgccctt cctcctcctc    120

ctcctctgcc gccgcctcct cagtcgccgc cgcctcctca gtcgccgccg cccgcgccgc    180

ccgcgccctc cgcgcgcctc tgagcccgcg ccgggccgcg ccggcccctt cccatgcggg    240

cggcgcgggc cctgggaggg gcgcccggag ccagccgcgc agcatgcact ggggggttgg    300

ctttgcttcg tccaggccgt gcgtggtgga tctgagctgg aaccagagca tctccttctt    360

cggctggtgg gccgggtccg aggagccctt ctccttttat ggggacatca tcgctttccc    420

tttgcaggat tacggtggga tcatggcagg gctgggctcc gatccctggt ggaagaaaac    480

cctttacttg accgggggag ctttgctggc cgcagctgcg tatctgctcc acgaactcct    540

ggtcattagg aaacagcaag agattgactc taaagatgct attattttgc atcagtttgc    600

aagacctaac aatggtgttc caagtttatc tcctttctgt ttaaagatgg aaacttattt    660

aaggatggct gacttaccgt atcagaacta ttttggtgga aaactctctg ctcaagggaa    720

aatgccttgg attgaatata atcatgaaaa agtttctggc acagaattca taattgactt    780

tctggaagag aagcttggag tgaatttaaa caaaaacctt ggccctcatg aaagagccat    840

ctccagagcg gtgaccaaga tggtggagga gcacttctac tggacgttag cttattgcca    900

gtgggtggac aatctcaatg agacccggaa gatgctctct cttagtggtg gtggtccctt    960

cagcaacctg ctgaggtggg ttgtgtgcca cataacgaaa ggaattgtga aacgcgagat   1020

gcacggccac ggcattggcc gcttctccga ggaagagatt tacatgctga tggagaagga   1080

catgcggtct ttagcagggc ttttgggtga taagaagtac atcatggggc ccaagctttc   1140

cactcttgac gccactgtct ttggacactt ggcacaggca atgtggacct taccagggac   1200

aagacccgaa cggctgatca aaggtgagct gatcaacctt gccatgtact gtgagaggat   1260

aaggaggaaa ttttggccag agtggcacca cgatgatgac aataccatct atgagtctga   1320

ggagagcagc gaaggcagca aaacccacac cccgctgctg gattttagct tttactcaag   1380

gacagagacc tttgaagatg agggagcaga aaacagtttt tccagaaccc cagacacaga   1440

ttttactgga cactcactct ttgattcgga tgtggacatg gatgactata cagaccacga   1500

acagtgcaag tgacgtccag cctcactgac cctcttcctt gggacctgcc actccctggg   1560

tcggtccatt ttcccaggta gcaatccatc cgagctggga ggagatcttc gtgcttggca   1620

gagttttcac atgctaactg gactatagca gccttatttc tttttttgta caaacaaaac   1680

acagaaccat tcagatgact ccattgaaaa caaacaggca aaaaataatg tcagcatggt   1740

tcctgaaatc catttttgtt ttcattagaa aactattaat aatattgtgt ggtagagcag   1800

gtgtaagagc tggttgtcag ctgatagttt ttatgatgat cctcttcaac cctgaggtct   1860

taattgtgag atggattctt gaacctcctt cctccaccag gatttgaagt aatgagagat   1920

atcatcagaa aaatgtttta cggtggctgc ttgtacttta tgtgtgtata ttgtatgttg   1980

agacataagt caaataaaat ccacagatat taaacgaaaa aaaaaaaaaa aaaa         2034


<210>  376
<211>  409
<212>  PRT
<213>  Homo sapiens

<400>  376

Met His Trp Gly Val Gly Phe Ala Ser Ser Arg Pro Cys Val Val Asp 
1               5                   10                  15


Leu Ser Trp Asn Gln Ser Ile Ser Phe Phe Gly Trp Trp Ala Gly Ser 
            20                  25                  30


Glu Glu Pro Phe Ser Phe Tyr Gly Asp Ile Ile Ala Phe Pro Leu Gln 
        35                  40                  45


Asp Tyr Gly Gly Ile Met Ala Gly Leu Gly Ser Asp Pro Trp Trp Lys 
    50                  55                  60


Lys Thr Leu Tyr Leu Thr Gly Gly Ala Leu Leu Ala Ala Ala Ala Tyr 
65                  70                  75                  80


Leu Leu His Glu Leu Leu Val Ile Arg Lys Gln Gln Glu Ile Asp Ser 
                85                  90                  95


Lys Asp Ala Ile Ile Leu His Gln Phe Ala Arg Pro Asn Asn Gly Val 
            100                 105                 110


Pro Ser Leu Ser Pro Phe Cys Leu Lys Met Glu Thr Tyr Leu Arg Met 
        115                 120                 125


Ala Asp Leu Pro Tyr Gln Asn Tyr Phe Gly Gly Lys Leu Ser Ala Gln 
    130                 135                 140


Gly Lys Met Pro Trp Ile Glu Tyr Asn His Glu Lys Val Ser Gly Thr 
145                 150                 155                 160


Glu Phe Ile Ile Asp Phe Leu Glu Glu Lys Leu Gly Val Asn Leu Asn 
                165                 170                 175


Lys Asn Leu Gly Pro His Glu Arg Ala Ile Ser Arg Ala Val Thr Lys 
            180                 185                 190


Met Val Glu Glu His Phe Tyr Trp Thr Leu Ala Tyr Cys Gln Trp Val 
        195                 200                 205


Asp Asn Leu Asn Glu Thr Arg Lys Met Leu Ser Leu Ser Gly Gly Gly 
    210                 215                 220


Pro Phe Ser Asn Leu Leu Arg Trp Val Val Cys His Ile Thr Lys Gly 
225                 230                 235                 240


Ile Val Lys Arg Glu Met His Gly His Gly Ile Gly Arg Phe Ser Glu 
                245                 250                 255


Glu Glu Ile Tyr Met Leu Met Glu Lys Asp Met Arg Ser Leu Ala Gly 
            260                 265                 270


Leu Leu Gly Asp Lys Lys Tyr Ile Met Gly Pro Lys Leu Ser Thr Leu 
        275                 280                 285


Asp Ala Thr Val Phe Gly His Leu Ala Gln Ala Met Trp Thr Leu Pro 
    290                 295                 300


Gly Thr Arg Pro Glu Arg Leu Ile Lys Gly Glu Leu Ile Asn Leu Ala 
305                 310                 315                 320


Met Tyr Cys Glu Arg Ile Arg Arg Lys Phe Trp Pro Glu Trp His His 
                325                 330                 335


Asp Asp Asp Asn Thr Ile Tyr Glu Ser Glu Glu Ser Ser Glu Gly Ser 
            340                 345                 350


Lys Thr His Thr Pro Leu Leu Asp Phe Ser Phe Tyr Ser Arg Thr Glu 
        355                 360                 365


Thr Phe Glu Asp Glu Gly Ala Glu Asn Ser Phe Ser Arg Thr Pro Asp 
    370                 375                 380


Thr Asp Phe Thr Gly His Ser Leu Phe Asp Ser Asp Val Asp Met Asp 
385                 390                 395                 400


Asp Tyr Thr Asp His Glu Gln Cys Lys 
                405


<210>  377
<211>  2386
<212>  DNA
<213>  Homo sapiens

<400>  377
agcatacgcc gagccggtct ttgagcgcta acgtctttct gtctccccgc ggtggtgatg     60

acggtgaaaa ctgaggctgc taagggcacc ctcacttact ccaggatgag gggcatggtg    120

gcaattctca tcgctttcat gaagcagagg aggatgggtc tgaacgactt tattcagaag    180

attgccaata actcctatgc atgcaaacac cctgaagttc agtccatctt gaagatctcc    240

caacctcagg agcctgagct tatgaatgcc aacccttctc ctccaccaag tccttctcag    300

caaatcaacc ttggcccgtc gtccaatcct catgctaaac catctgactt tcacttcttg    360

aaagtgatcg gaaagggcag ttttggaaag gttcttctag caagacacaa ggcagaagaa    420

gtgttctatg cagtcaaagt tttacagaag aaagcaatcc tgaaaaagaa agaggagaag    480

catattatgt cggagcggaa tgttctgttg aagaatgtga agcacccttt cctggtgggc    540

cttcacttct ctttccagac tgctgacaaa ttgtactttg tcctagacta cattaatggt    600

ggagagttgt tctaccatct ccagagggaa cgctgcttcc tggaaccacg ggctcgtttc    660

tatgctgctg aaatagccag tgccttgggc tacctgcatt cactgaacat cgtttataga    720

gacttaaaac cagagaatat tttgctagat tcacagggac acattgtcct tactgacttc    780

ggactctgca aggagaacat tgaacacaac agcacaacat ccaccttctg tggcacgccg    840

gagtatctcg cacctgaggt gcttcataag cagccttatg acaggactgt ggactggtgg    900

tgcctgggag ctgtcttgta tgagatgctg tatggcctgc cgccttttta tagccgaaac    960

acagctgaaa tgtacgacaa cattctgaac aagcctctcc agctgaaacc aaatattaca   1020

aattccgcaa gacacctcct ggagggcctc ctgcagaagg acaggacaaa gcggctcggg   1080

gccaaggatg acttcatgga gattaagagt catgtcttct tctccttaat taactgggat   1140

gatctcatta ataagaagat tactccccct tttaacccaa atgtgagtgg gcccaacgac   1200

ctacggcact ttgaccccga gtttaccgaa gagcctgtcc ccaactccat tggcaagtcc   1260

cctgacagcg tcctcgtcac agccagcgtc aaggaagctg ccgaggcttt cctaggcttt   1320

tcctatgcgc ctcccacgga ctctttcctc tgaaccctgt tagggcttgg ttttaaagga   1380

ttttatgtgt gtttccgaat gttttagtta gccttttggt ggagccgcca gctgacagga   1440

catcttacaa gagaatttgc acatctctgg aagcttagca atcttattgc acactgttcg   1500

ctggaagctt tttgaagagc acattctcct cagtgagctc atgaggtttt catttttatt   1560

cttccttcca acgtggtgct atctctgaaa cgagcgttag agtgccgcct tagacggagg   1620

caggagtttc gttagaaagc ggacgctgtt ctaaaaaagg tctcctgcag atctgtctgg   1680

gctgtgatga cgaatattat gaaatgtgcc ttttctgaag agattgtgtt agctccaaag   1740

cttttcctat cgcagtgttt cagttcttta ttttcccttg tggatatgct gtgtgaaccg   1800

tcgtgtgagt gtggtatgcc tgatcacaga tggattttgt tataagcatc aatgtgacac   1860

ttgcaggaca ctacaacgtg ggacattgtt tgtttcttcc atatttggaa gataaattta   1920

tgtgtagact tttttgtaag atacggttaa taactaaaat ttattgaaat ggtcttgcaa   1980

tgactcgtat tcagatgctt aaagaaagca ttgctgctac aaatatttct atttttagaa   2040

agggttttta tggaccaatg ccccagttgt cagtcagagc cgttggtgtt tttcattgtt   2100

taaaatgtca cctgtaaaat gggcattatt tatgtttttt tttttgcatt cctgataatt   2160

gtatgtattg tataaagaac gtctgtacat tgggttataa cactagtata tttaaactta   2220

caggcttatt tgtaatgtaa accaccattt taatgtactg taattaacat ggttataata   2280

cgtacaatcc ttccctcatc ccatcacaca actttttttg tgtgtgataa actgattttg   2340

gtttgcaata aaaccttgaa aaatatttac aaaaaaaaaa aaaaaa                  2386


<210>  378
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  378

Met Thr Val Lys Thr Glu Ala Ala Lys Gly Thr Leu Thr Tyr Ser Arg 
1               5                   10                  15


Met Arg Gly Met Val Ala Ile Leu Ile Ala Phe Met Lys Gln Arg Arg 
            20                  25                  30


Met Gly Leu Asn Asp Phe Ile Gln Lys Ile Ala Asn Asn Ser Tyr Ala 
        35                  40                  45


Cys Lys His Pro Glu Val Gln Ser Ile Leu Lys Ile Ser Gln Pro Gln 
    50                  55                  60


Glu Pro Glu Leu Met Asn Ala Asn Pro Ser Pro Pro Pro Ser Pro Ser 
65                  70                  75                  80


Gln Gln Ile Asn Leu Gly Pro Ser Ser Asn Pro His Ala Lys Pro Ser 
                85                  90                  95


Asp Phe His Phe Leu Lys Val Ile Gly Lys Gly Ser Phe Gly Lys Val 
            100                 105                 110


Leu Leu Ala Arg His Lys Ala Glu Glu Val Phe Tyr Ala Val Lys Val 
        115                 120                 125


Leu Gln Lys Lys Ala Ile Leu Lys Lys Lys Glu Glu Lys His Ile Met 
    130                 135                 140


Ser Glu Arg Asn Val Leu Leu Lys Asn Val Lys His Pro Phe Leu Val 
145                 150                 155                 160


Gly Leu His Phe Ser Phe Gln Thr Ala Asp Lys Leu Tyr Phe Val Leu 
                165                 170                 175


Asp Tyr Ile Asn Gly Gly Glu Leu Phe Tyr His Leu Gln Arg Glu Arg 
            180                 185                 190


Cys Phe Leu Glu Pro Arg Ala Arg Phe Tyr Ala Ala Glu Ile Ala Ser 
        195                 200                 205


Ala Leu Gly Tyr Leu His Ser Leu Asn Ile Val Tyr Arg Asp Leu Lys 
    210                 215                 220


Pro Glu Asn Ile Leu Leu Asp Ser Gln Gly His Ile Val Leu Thr Asp 
225                 230                 235                 240


Phe Gly Leu Cys Lys Glu Asn Ile Glu His Asn Ser Thr Thr Ser Thr 
                245                 250                 255


Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val Leu His Lys Gln 
            260                 265                 270


Pro Tyr Asp Arg Thr Val Asp Trp Trp Cys Leu Gly Ala Val Leu Tyr 
        275                 280                 285


Glu Met Leu Tyr Gly Leu Pro Pro Phe Tyr Ser Arg Asn Thr Ala Glu 
    290                 295                 300


Met Tyr Asp Asn Ile Leu Asn Lys Pro Leu Gln Leu Lys Pro Asn Ile 
305                 310                 315                 320


Thr Asn Ser Ala Arg His Leu Leu Glu Gly Leu Leu Gln Lys Asp Arg 
                325                 330                 335


Thr Lys Arg Leu Gly Ala Lys Asp Asp Phe Met Glu Ile Lys Ser His 
            340                 345                 350


Val Phe Phe Ser Leu Ile Asn Trp Asp Asp Leu Ile Asn Lys Lys Ile 
        355                 360                 365


Thr Pro Pro Phe Asn Pro Asn Val Ser Gly Pro Asn Asp Leu Arg His 
    370                 375                 380


Phe Asp Pro Glu Phe Thr Glu Glu Pro Val Pro Asn Ser Ile Gly Lys 
385                 390                 395                 400


Ser Pro Asp Ser Val Leu Val Thr Ala Ser Val Lys Glu Ala Ala Glu 
                405                 410                 415


Ala Phe Leu Gly Phe Ser Tyr Ala Pro Pro Thr Asp Ser Phe Leu 
            420                 425                 430


<210>  379
<211>  210
<212>  DNA
<213>  Homo sapiens

<400>  379
atggcccgga tagcaaccac tggagctggc gtggggtaca cggtgggtca taccatcact     60

gggggcttca atgaaggaag taatgctgag cctgcaagtc ctgacatcac ctaccaggag    120

ccccagggaa cccagatgtc acagcggcag cagccttgct tctatgagat aaaaccgttt    180

ttggagtgtg cccggaaccg ggtgacataa                                     210


<210>  380
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  380

Met Ala Arg Ile Ala Thr Thr Gly Ala Gly Val Gly Tyr Thr Val Gly 
1               5                   10                  15


His Thr Ile Thr Gly Gly Phe Asn Glu Gly Ser Asn Ala Glu Pro Ala 
            20                  25                  30


Ser Pro Asp Ile Thr Tyr Gln Glu Pro Gln Gly Thr Gln Met Ser Gln 
        35                  40                  45


Arg Gln Gln Pro Cys Phe Tyr Glu Ile Lys Pro Phe Leu Glu Cys Ala 
    50                  55                  60


Arg Asn Arg Val Thr 
65


<210>  381
<211>  5538
<212>  DNA
<213>  Homo sapiens

<400>  381
gcggcacaga gccgcggctt gctttcagga cacgggtcgc tggcgggtta ggtggctgcg     60

tggccgcctc acttcgcgca cgcgccgcta ggctggggga gttgatttgc actgctccgg    120

gtgtcggctc cggcgggacg ggcggttctg cgtacccctc tccagtgtca acctggggct    180

gaatcttcaa cctgtcaaag ccttcttaat tatgtctgag aaaaggatcc tgattgagtc    240

aatgctttgc attctcagtc ctctgcataa agctgagaga tgcctacagc tgagagtgaa    300

gcaaaagtaa aaaccaaagt tcgctttgaa gaattgctta agacccacag tgatctaatg    360

cgtgaaaaga aaaaactgaa gaaaaaactt gtcaggtctg aagaaaacat ctcacctgac    420

actattagaa gcaatcttca ctatatgaaa gaaactacaa gtgatgatcc cgacactatt    480

agaagcaatc ttccccatat taaagaaact acaagtgatg atgtaagtgc tgctaacact    540

aacaacctga agaagagcac gagagtcact aaaaacaaat tgaggaacac acagttagca    600

actgaaaatc ctaatggtga tgctagtgta gaggaagaca aacaaggaaa gccaaataaa    660

aaggtgataa agacggtgcc ccagttgact acacaagacc tgaaaccgga aactcctgag    720

aataaggttg attctacaca ccagaaaaca catacaaagc cacagccagg cgttgatcat    780

cagaaaagtg agaaggcaaa tgagggaaga gaagagactg atttagaaga ggatgaagaa    840

ttgatgcaag catatcagtg ccatgtaact gaagaaatgg caaaggagat taagaggaaa    900

ataagaaaga aactgaaaga acagttgact tactttccct cagatacttt attccatgat    960

gacaaactaa gcagtgaaaa aaggaaaaag aaaaaggaag ttccagtctt ctctaaagct   1020

gaaacaagta cattgaccat ctctggtgac acagttgaag gtgaacaaaa gaaagaatct   1080

tcagttagat cagtttcttc agattctcat caagatgatg aaataagctc aatggaacaa   1140

agcacagaag acagcatgca agatgataca aaacctaaac caaaaaaaac aaaaaagaag   1200

actaaagcag ttgcagataa taatgaagat gttgatggtg atggtgttca tgaaataaca   1260

agccgagata gcccggttta tcccaaatgt ttgcttgatg atgaccttgt cttgggagtt   1320

tacattcacc gaactgatag acttaagtca gattttatga tttctcaccc aatggtaaaa   1380

attcatgtgg ttgatgagca tactggtcaa tatgtcaaga aagatgatag tggacggcct   1440

gtttcatctt actatgaaaa agagaatgtg gattatattc ttcctattat gacccagcca   1500

tatgatttta aacagttaaa atcaagactt ccagagtggg aagaacaaat tgtatttaat   1560

gaaaattttc cctatttgct tcgaggctct gatgagagtc ctaaagtcat cctgttcttt   1620

gagattcttg atttcttaag cgtggatgaa attaagaata attctgaggt tcaaaaccaa   1680

gaatgtggct ttcggaaaat tgcctgggca tttcttaagc ttctgggagc caatggaaat   1740

gcaaacatca actcaaaact tcgcttgcag ctatattacc cacctactaa gcctcgatcc   1800

ccattaagtg ttgttgaggc atttgaatgg tggtcaaaat gtccaagaaa tcattaccca   1860

tcaacactgt acgtaactgt aagaggactg aaagttccag actgtataaa gccatcttac   1920

cgctctatga tggctcttca ggaggaaaaa ggtaaaccag tgcattgtga acgtcaccat   1980

gagtcaagct cagtagacac agaacctgga ttagaagagt caaaggaagt aataaagtgg   2040

aaacgactcc ctgggcaggc ttgccgtatc ccaaacaaac acctcttctc actaaatgca   2100

ggagaacgag gatgtttttg tcttgatttc tcccacaatg gaagaatatt agcagcagct   2160

tgtgccagcc gggatggata tccaattatt ttatatgaaa ttccttctgg acgtttcatg   2220

agagaattgt gtggccacct caatatcatt tatgatcttt cctggtcaaa agatgatcac   2280

tacatcctta cttcatcatc tgatggcact gccaggatat ggaaaaatga aataaacaat   2340

acaaatactt tcagagtttt acctcatcct tcttttgttt acacggctaa attccatcca   2400

gctgtaagag agctagtagt tacaggatgc tatgattcca tgatacggat atggaaagtt   2460

gagatgagag aagattctgc catattggtc cgacagtttg atgttcacaa aagttttatc   2520

aactcacttt gttttgatac tgaaggtcat catatgtatt caggagattg tacaggggtg   2580

attgttgttt ggaataccta tgtcaagatt aatgatttgg aacattcagt gcaccactgg   2640

actataaata aggaaattaa agaaactgag tttaagggaa ttccaataag ttatttggag   2700

attcatccca atggaaaacg tttgttaatc cataccaaag acagtacttt gagaattatg   2760

gatctccgga tattagtagc aaggaagttt gtaggagcag caaattatcg ggagaagatt   2820

catagtactt tgactccatg tgggactttt ctgtttgctg gaagtgagga tggtatagtg   2880

tatgtttgga acccagaaac aggagaacaa gtagccatgt attctgactt gccattcaag   2940

tcacccattc gagacatttc ttatcatcca tttgaaaata tggttgcatt ctgtgcattt   3000

gggcaaaatg agccaattct tctgtatatt tacgatttcc atgttgccca gcaggaggct   3060

gaaatgttca aacgctacaa tggaacattt ccattacctg gaatacacca aagtcaagat   3120

gccctatgta cctgtccaaa actaccccat caaggctctt ttcagattga tgaatttgtc   3180

cacactgaaa gttcttcaac gaagatgcag ctagtaaaac agaggcttga aactgtcaca   3240

gaggtgatac gttcctgtgc tgcaaaagtc aacaaaaatc tctcatttac ttcaccacca   3300

gcagtttcct cacaacagtc taagttaaag cagtcaaaca tgctgaccgc tcaagagatt   3360

ctacatcagt ttggtttcac tcagaccggg attatcagca tagaaagaaa gccttgtaac   3420

catcaggtag atacagcacc aacggtagtg gctctttatg actacacagc gaatcgatca   3480

gatgaactaa ccatccatcg cggagacatt atccgagtgt ttttcaaaga taatgaagac   3540

tggtggtatg gcagcatagg aaagggacag gaaggttatt ttccagctaa tcatgtggct   3600

agtgaaacac tgtatcaaga actgcctcct gagataaagg agcgatcccc tcctttaagc   3660

cctgaggaaa aaactaaaat agaaaaatct ccagctcctc aaaagcaatc aatcaataag   3720

aacaagtccc aggacttcag actaggctca gaatctatga cacattctga aatgagaaaa   3780

gaacagagcc atgaggacca aggacacata atggatacac ggatgaggaa gaacaagcaa   3840

gcaggcagaa aagtcactct aatagagtaa agaattgaag aaaagttaag agctgccgaa   3900

atgcacagag gtgaaaatga caaaccaaat ggaatttctc ttcagagttc agaattttca   3960

gatactaagg aggaagaaag gatccactac ttcttgttct tatgaatgac tctagaaaaa   4020

tcagaatcaa gttgtgggtg gaaaaatcaa cgtggccttt gagttcagtt gttataaacc   4080

attgtgacta ttgttggtca aagtattggt acttatattg ttagtaattg catcataatt   4140

acattaccag tgttggaaaa ctaatgaaga aaacactgta attgctactc agcaaatgtg   4200

aataaaaggt gtttgcgtta ttaggatgtc tgttaagtaa tcatttaata ttattatatt   4260

ggtaatggtt gtatgtgtga tgctatgccc agaatatgaa gtatctgttt ttgaaattca   4320

ctttatttaa aagataagca gctgactggg cacggtgcct catgcctgta atcctagcac   4380

cttgggaggc tgaggcaggt ggatcaccta aggtcaggag ttcaacaaca ccagcctgac   4440

caacatggtg aaaccccatc tctactaaaa atacaaaaat cagccgggtc tcatggcagg   4500

cacctgtaat cccatctact gaggcaggag aattgcttga cccaggaggc agaggttgca   4560

gtgagccaag atcacgccat tgcactccag cctgggggac agagcaagac tctatctcca   4620

aaaaacaaaa aagataagca gctttagaat atggcgcatt caaaacagtc tcagtaacaa   4680

agacattaaa agaaaacaat ttactttcta attaaaattt tgtgtttctt aagatcaaat   4740

catataggta acttcataga cctaaattaa aagtgatttt tggctggact ggcaacaatg   4800

ttcccaatgt ctttactttt taaaaaaggc ttttcatatt taagcacata cctattttgt   4860

agacttacat tgtttaatat ttattttaat cttaatattt ttacattatt atattgcatt   4920

atttattttt tctaagttcc agaataatag tgtcattatt atagactata tgttttgaag   4980

tttgatatta taatgggata ttcatttttt gttcttttct tgactccttt ctcaagtgtg   5040

tgataaggtc tgctgataaa atatttaacc ccaagaaagt gaaaactaat ataaaattag   5100

aaagacctat ccaaattaga cagtcaattc cattaaaata agaagtgaga aaaacaatgt   5160

tgggcattga ggtgtaaatt ttgcccagat gtatacccag tgtgaaatat cttctaataa   5220

aaatatattt ggctcttatc cctgcacatg tagaggcata aaaattggta aacatgtccc   5280

gctgtgtaga actttaaaaa aaaggcattt ttgaaagtgt tgagtggcac tgataactgg   5340

tgaagcctac agccatccgc ccaaaagtct gttctgatgg cactgagttt tcattgttct   5400

ggatgtataa gtctgtgtgt caggtacagc tgggcccagc cagcttgagt cactcttgta   5460

caagcttgtt tttttctgtc ttgtgaatgc acttgataat ttaaaaataa aaatatctgt   5520

ttctctgcaa aaaaaaaa                                                 5538


<210>  382
<211>  1196
<212>  PRT
<213>  Homo sapiens

<400>  382

Met Pro Thr Ala Glu Ser Glu Ala Lys Val Lys Thr Lys Val Arg Phe 
1               5                   10                  15


Glu Glu Leu Leu Lys Thr His Ser Asp Leu Met Arg Glu Lys Lys Lys 
            20                  25                  30


Leu Lys Lys Lys Leu Val Arg Ser Glu Glu Asn Ile Ser Pro Asp Thr 
        35                  40                  45


Ile Arg Ser Asn Leu His Tyr Met Lys Glu Thr Thr Ser Asp Asp Pro 
    50                  55                  60


Asp Thr Ile Arg Ser Asn Leu Pro His Ile Lys Glu Thr Thr Ser Asp 
65                  70                  75                  80


Asp Val Ser Ala Ala Asn Thr Asn Asn Leu Lys Lys Ser Thr Arg Val 
                85                  90                  95


Thr Lys Asn Lys Leu Arg Asn Thr Gln Leu Ala Thr Glu Asn Pro Asn 
            100                 105                 110


Gly Asp Ala Ser Val Glu Glu Asp Lys Gln Gly Lys Pro Asn Lys Lys 
        115                 120                 125


Val Ile Lys Thr Val Pro Gln Leu Thr Thr Gln Asp Leu Lys Pro Glu 
    130                 135                 140


Thr Pro Glu Asn Lys Val Asp Ser Thr His Gln Lys Thr His Thr Lys 
145                 150                 155                 160


Pro Gln Pro Gly Val Asp His Gln Lys Ser Glu Lys Ala Asn Glu Gly 
                165                 170                 175


Arg Glu Glu Thr Asp Leu Glu Glu Asp Glu Glu Leu Met Gln Ala Tyr 
            180                 185                 190


Gln Cys His Val Thr Glu Glu Met Ala Lys Glu Ile Lys Arg Lys Ile 
        195                 200                 205


Arg Lys Lys Leu Lys Glu Gln Leu Thr Tyr Phe Pro Ser Asp Thr Leu 
    210                 215                 220


Phe His Asp Asp Lys Leu Ser Ser Glu Lys Arg Lys Lys Lys Lys Glu 
225                 230                 235                 240


Val Pro Val Phe Ser Lys Ala Glu Thr Ser Thr Leu Thr Ile Ser Gly 
                245                 250                 255


Asp Thr Val Glu Gly Glu Gln Lys Lys Glu Ser Ser Val Arg Ser Val 
            260                 265                 270


Ser Ser Asp Ser His Gln Asp Asp Glu Ile Ser Ser Met Glu Gln Ser 
        275                 280                 285


Thr Glu Asp Ser Met Gln Asp Asp Thr Lys Pro Lys Pro Lys Lys Thr 
    290                 295                 300


Lys Lys Lys Thr Lys Ala Val Ala Asp Asn Asn Glu Asp Val Asp Gly 
305                 310                 315                 320


Asp Gly Val His Glu Ile Thr Ser Arg Asp Ser Pro Val Tyr Pro Lys 
                325                 330                 335


Cys Leu Leu Asp Asp Asp Leu Val Leu Gly Val Tyr Ile His Arg Thr 
            340                 345                 350


Asp Arg Leu Lys Ser Asp Phe Met Ile Ser His Pro Met Val Lys Ile 
        355                 360                 365


His Val Val Asp Glu His Thr Gly Gln Tyr Val Lys Lys Asp Asp Ser 
    370                 375                 380


Gly Arg Pro Val Ser Ser Tyr Tyr Glu Lys Glu Asn Val Asp Tyr Ile 
385                 390                 395                 400


Leu Pro Ile Met Thr Gln Pro Tyr Asp Phe Lys Gln Leu Lys Ser Arg 
                405                 410                 415


Leu Pro Glu Trp Glu Glu Gln Ile Val Phe Asn Glu Asn Phe Pro Tyr 
            420                 425                 430


Leu Leu Arg Gly Ser Asp Glu Ser Pro Lys Val Ile Leu Phe Phe Glu 
        435                 440                 445


Ile Leu Asp Phe Leu Ser Val Asp Glu Ile Lys Asn Asn Ser Glu Val 
    450                 455                 460


Gln Asn Gln Glu Cys Gly Phe Arg Lys Ile Ala Trp Ala Phe Leu Lys 
465                 470                 475                 480


Leu Leu Gly Ala Asn Gly Asn Ala Asn Ile Asn Ser Lys Leu Arg Leu 
                485                 490                 495


Gln Leu Tyr Tyr Pro Pro Thr Lys Pro Arg Ser Pro Leu Ser Val Val 
            500                 505                 510


Glu Ala Phe Glu Trp Trp Ser Lys Cys Pro Arg Asn His Tyr Pro Ser 
        515                 520                 525


Thr Leu Tyr Val Thr Val Arg Gly Leu Lys Val Pro Asp Cys Ile Lys 
    530                 535                 540


Pro Ser Tyr Arg Ser Met Met Ala Leu Gln Glu Glu Lys Gly Lys Pro 
545                 550                 555                 560


Val His Cys Glu Arg His His Glu Ser Ser Ser Val Asp Thr Glu Pro 
                565                 570                 575


Gly Leu Glu Glu Ser Lys Glu Val Ile Lys Trp Lys Arg Leu Pro Gly 
            580                 585                 590


Gln Ala Cys Arg Ile Pro Asn Lys His Leu Phe Ser Leu Asn Ala Gly 
        595                 600                 605


Glu Arg Gly Cys Phe Cys Leu Asp Phe Ser His Asn Gly Arg Ile Leu 
    610                 615                 620


Ala Ala Ala Cys Ala Ser Arg Asp Gly Tyr Pro Ile Ile Leu Tyr Glu 
625                 630                 635                 640


Ile Pro Ser Gly Arg Phe Met Arg Glu Leu Cys Gly His Leu Asn Ile 
                645                 650                 655


Ile Tyr Asp Leu Ser Trp Ser Lys Asp Asp His Tyr Ile Leu Thr Ser 
            660                 665                 670


Ser Ser Asp Gly Thr Ala Arg Ile Trp Lys Asn Glu Ile Asn Asn Thr 
        675                 680                 685


Asn Thr Phe Arg Val Leu Pro His Pro Ser Phe Val Tyr Thr Ala Lys 
    690                 695                 700


Phe His Pro Ala Val Arg Glu Leu Val Val Thr Gly Cys Tyr Asp Ser 
705                 710                 715                 720


Met Ile Arg Ile Trp Lys Val Glu Met Arg Glu Asp Ser Ala Ile Leu 
                725                 730                 735


Val Arg Gln Phe Asp Val His Lys Ser Phe Ile Asn Ser Leu Cys Phe 
            740                 745                 750


Asp Thr Glu Gly His His Met Tyr Ser Gly Asp Cys Thr Gly Val Ile 
        755                 760                 765


Val Val Trp Asn Thr Tyr Val Lys Ile Asn Asp Leu Glu His Ser Val 
    770                 775                 780


His His Trp Thr Ile Asn Lys Glu Ile Lys Glu Thr Glu Phe Lys Gly 
785                 790                 795                 800


Ile Pro Ile Ser Tyr Leu Glu Ile His Pro Asn Gly Lys Arg Leu Leu 
                805                 810                 815


Ile His Thr Lys Asp Ser Thr Leu Arg Ile Met Asp Leu Arg Ile Leu 
            820                 825                 830


Val Ala Arg Lys Phe Val Gly Ala Ala Asn Tyr Arg Glu Lys Ile His 
        835                 840                 845


Ser Thr Leu Thr Pro Cys Gly Thr Phe Leu Phe Ala Gly Ser Glu Asp 
    850                 855                 860


Gly Ile Val Tyr Val Trp Asn Pro Glu Thr Gly Glu Gln Val Ala Met 
865                 870                 875                 880


Tyr Ser Asp Leu Pro Phe Lys Ser Pro Ile Arg Asp Ile Ser Tyr His 
                885                 890                 895


Pro Phe Glu Asn Met Val Ala Phe Cys Ala Phe Gly Gln Asn Glu Pro 
            900                 905                 910


Ile Leu Leu Tyr Ile Tyr Asp Phe His Val Ala Gln Gln Glu Ala Glu 
        915                 920                 925


Met Phe Lys Arg Tyr Asn Gly Thr Phe Pro Leu Pro Gly Ile His Gln 
    930                 935                 940


Ser Gln Asp Ala Leu Cys Thr Cys Pro Lys Leu Pro His Gln Gly Ser 
945                 950                 955                 960


Phe Gln Ile Asp Glu Phe Val His Thr Glu Ser Ser Ser Thr Lys Met 
                965                 970                 975


Gln Leu Val Lys Gln Arg Leu Glu Thr Val Thr Glu Val Ile Arg Ser 
            980                 985                 990


Cys Ala Ala Lys Val Asn Lys Asn Leu Ser Phe Thr Ser Pro Pro Ala 
        995                 1000                1005


Val Ser Ser Gln Gln Ser Lys Leu Lys Gln Ser Asn Met Leu Thr Ala 
    1010                1015                1020


Gln Glu Ile Leu His Gln Phe Gly Phe Thr Gln Thr Gly Ile Ile Ser 
1025                1030                1035                1040


Ile Glu Arg Lys Pro Cys Asn His Gln Val Asp Thr Ala Pro Thr Val 
                1045                1050                1055


Val Ala Leu Tyr Asp Tyr Thr Ala Asn Arg Ser Asp Glu Leu Thr Ile 
            1060                1065                1070


His Arg Gly Asp Ile Ile Arg Val Phe Phe Lys Asp Asn Glu Asp Trp 
        1075                1080                1085


Trp Tyr Gly Ser Ile Gly Lys Gly Gln Glu Gly Tyr Phe Pro Ala Asn 
    1090                1095                1100


His Val Ala Ser Glu Thr Leu Tyr Gln Glu Leu Pro Pro Glu Ile Lys 
1105                1110                1115                1120


Glu Arg Ser Pro Pro Leu Ser Pro Glu Glu Lys Thr Lys Ile Glu Lys 
                1125                1130                1135


Ser Pro Ala Pro Gln Lys Gln Ser Ile Asn Lys Asn Lys Ser Gln Asp 
            1140                1145                1150


Phe Arg Leu Gly Ser Glu Ser Met Thr His Ser Glu Met Arg Lys Glu 
        1155                1160                1165


Gln Ser His Glu Asp Gln Gly His Ile Met Asp Thr Arg Met Arg Lys 
    1170                1175                1180


Asn Lys Gln Ala Gly Arg Lys Val Thr Leu Ile Glu 
1185                1190                1195


<210>  383
<211>  1007
<212>  DNA
<213>  Homo sapiens

<400>  383
atggtgaagg tgaaggccag agtcaacgaa tttggctata ctgggtgcct ggtcactagg     60

gctgctttta actctggtaa agtggatatt gttgccatca atgacccctt cattgacctc    120

aactacctgg cctacatgct ccagtatgat tccacccatg gcaagttcca tggcaccatc    180

aaggctgaga atgggaagct tgtcatcaat ggaaatccca ttaccatctt ccaggagtaa    240

gatcccacca aaatcaaatg gggcgatgct ggcactgagt acgttgtgga gtccaccagc    300

atcttcaccg ccatggagaa ggttggggct catttgcaga ggggagccaa aagggtcatg    360

atctttgccc cctctactga agccatcatg ttcatgatga aagtgaatta tgagaagtat    420

gacaacagcc ttaagatcat cagcaatgcc tcctgtacca ccaactgctt agcgcccctg    480

gccaaggtca tccatgacaa ctctggtatt gttgaaagac tcatgattac agtccatgtc    540

atcactacca cccagaaaac tgtggatggc ccttgcagga aactgcggcc tgatggccac    600

agggctctcc agaacatcat acctgcatct actagcactg ccaaggcaat ggtcaaggtc    660

atccctgagc tgaacaagaa gctcactggc atggcctccc atgtccccac tgccaaggtg    720

ttggtcgtgg acccgacctg ccatctggaa aacctgccaa atattatgac atcaagaaga    780

tgatgaagca ggcttcagag gatcctatca agggcatcct gggctacact gagcaccaga    840

ttgtctcctc cgacttcaac agtgacacac agtcttccac ctttgatgct ggggctggca    900

ttaccctcaa cgaccacttt gtcaagctca tttcctggta tgacaatgaa tttggctaca    960

gcaacagggt ggtggacctc atggcccaca tggcttccaa ggaataa                 1007


<210>  384
<211>  10835
<212>  DNA
<213>  Homo sapiens

<400>  384
caaaaatcag tctgatctcg ggaaacctgg agaaatttat tttctgtact ctaatgttct     60

ttcattttgg tgaccatcaa ggtgctggga gaggaattag atggctgtaa ttcaaagtta    120

atggaattag atgcagcagt acagaaattc ttggaacaga atggccaact gggtaagcca    180

ctggccaaga agataggaaa actgactgaa cttcaccagc agaccattag acaagctgag    240

aatcggctct ccaagctcaa tcaggcagca tcacatttag aagaatacaa tgaaatgctt    300

gaattaattt tgaagtggat tgaaaaagct aaagtcttgg ctcatggaac tattgcatgg    360

aattctgcaa gccagcttcg ggaacaatat attttgcatc agaccctgct agaagaatcc    420

aaagaaattg acagtgagct ggaagcaatg actgagaaat tacagtacct cactagcgtg    480

tactgtacag aaaaaatgtc tcagcaagtg gcagaactgg gacgggagac tgaggagttg    540

cgacagatga tcaaaattcg tttgcagaac ctccaagatg cagctaagga tatgaaaaaa    600

tttgaagcag agttgaaaaa gttacaagct gccttggagc aagcccaggc aacactgact    660

tctccagaag ttggacgtct cagtctcaag gagcagctct ctcatcggca gcatttgttg    720

tctgagatgg agtcactgaa gccgaaggtg caagcagtgc agctctgcca gagtgccctc    780

cggatccccg aggatgtggt tgccagctta cctctctgtc atgctgctct gcggctgcag    840

gaagaggcca gccggctgca gcacaccgcc atccagcagt gtaacatcat gcaggcagct    900

gtggtacaat atgaacaata tgagcaagaa atgaaacatc tccagcaact gatagaagga    960

gctcacagag agattgagga taaacctgtt gccaccagta acatacagga gctgcaggct   1020

cagatttctc ggcatgagga gctggcgcag aaaattaagg gctaccagga gcagatcgct   1080

tctttgaatt ccaagtgcaa gatgctgacg atgaaagcca agcacgccac catgctgctg   1140

acggtgaccg aggtcgaggg gctggcggaa gggacagagg acctggatgg ggagctcctc   1200

cccacgcctt cggcccaccc ctctgtggtc atgatgactg caggtcgctg tcacactttg   1260

ctgtcaccgg tcactgagga gtctggggag gagggaacca acagtgagat ttcctctcca   1320

cctgcctgtc gctccccttc acctgtggct aatacagatg cttctgttaa ccaggacatt   1380

gcatattacc aagccttgtc tgctgagagg ttgcagacag atgctgcaaa aattcacccc   1440

agcacatccg catcccagga gttctatgaa ccgggattgg agccatccgc tactgccaaa   1500

ctgggtgatt tgcagcgttc ttgggaaacc ttaaagaatg tgatcagtga gaagcagcgc   1560

acactctatg aagctttgga acgccagcag aagtaccagg actccctcca gtccatctct   1620

acgaagatgg aggccattga gctgaaactc agtgagagcc cagagcctgg caggagtcca   1680

gaaagccaga tggctgaaca tcaggcattg atggatgaga ttctcatgct ccaggatgaa   1740

atcaatgagc tccagtcctc tctcgcagag gagctggtat ccgagtcttg tgaggccgac   1800

cctgcggagc agctggcctt gcagtccacg ctcactgtct tagccgagcg aatgtccacc   1860

atcaggatga aagcctcggg gaaacggcag cttttggagg agaagttgaa tgatcagctg   1920

gaggaacaaa ggcaggaaca ggccctgcag aggtatcgct gtgaagccga tgagctggac   1980

agctggctct tgagtaccaa ggccactctg gacactgcgc tgagtccacc caaggagccc   2040

atggacatgg aggcccagct tatggactgc cagaatatgc tggtggaaat agagcagaag   2100

gtggtggctt tatcagaact gtcagtccac aatgagaacc tgctgctgga gggcaaagct   2160

cacaccaagg acgaggccga gcagctggct ggaaagctga gaaggctcaa ggggagcctg   2220

ctggagctgc agagagccct gcatgataag cagctcaaca tgcagggaac agcacaggag   2280

aaggaggaga gcgatgttga cctaacagcc acgcagagcc ccggcgtcca ggaatggctg   2340

gcccaagctc gcaccacatg gacccagcag cggcagagca gtctccagca acaaaaagag   2400

ttagaacagg aattagccga gcagaagagt ctccttcgct cagtagccag tcgtggagag   2460

gagattctaa ttcaacattc ggcggcagag acctctggtg atgctggcga aaaacctgat   2520

gtgttatccc aggagttggg gatggaaggg gagaaatcat ccgctgaaga ccagatgaga   2580

atgaaatggg aaagcctaca tcaagaattt agtaccaagc agaaactact acagaatgtt   2640

ctggaacagg aacaagagca agtgctttat agcaggccaa atcgactctt gtctggtgtg   2700

ccactgtaca aaggggacgt gccaacccaa gataaatctg cagttacatc tttgctggat   2760

ggactgaacc aagccttcga ggaggtttca tcccagagtg gaggggcaaa gaggcagagt   2820

atacacttgg agcagaagtt gtatgatgga gtctcagcca cctctacttg gttggatgac   2880

gttgaagaac gtttatttgt tgccacagca cttttaccag aagaaacaga gacttgtctc   2940

ttcaaccaag agattcttgc caaagacatt aaggaaatgt ctgaagaaat ggataagaac   3000

aaaaacttgt tttcccaagc ttttccagag aatggtgata atcgagatgt tattgaagat   3060

actttgggtt gtcttttggg caggttatcc ttgctagact cagtagtgaa tcaacgatgt   3120

catcagatga aagaaagact tcagcaaata ctaaatttcc agaatgatct gaaagtgctg   3180

tttacatcac tggctgacaa caaatacatc attctgcaaa aactggcaaa tgtgtttgaa   3240

cagcccgtag cagaacaaat agaggcaata caacaggctg aagatggact caaagaattt   3300

gatgcaggaa tcattgaatt aaagaggcgt ggtgacaagc tacaggtcga gcagccgtcc   3360

atgcaagaac tctccaagct ccaggacatg tatgatgagc tgatgatgat cattggctcc   3420

cggaggagtg gtctgaatca gaaccttaca ctcaagagtc agtatgagag ggccctacaa   3480

gatctggctg acctgctaga aactggtcag gagaagatgg caggagacca gaaaatcatc   3540

gtgtcttcca aagaggaaat ccagcaacta cttgacaaac ataaggaata ctttcagggc   3600

ctggaatctc atatgatctt gactgaaaca ctcttcagaa agataatcag ctttgcagtc   3660

caaaaggaaa cccagttcca tacagagctg atggctcagg cttctgctgt actgaaacgg   3720

gctcacaaga ggggtgtgga gctggagtac attctagaga cgtggtccca tctggatgag   3780

gaccagcagg agctcagcag acagctggag gtggtggaaa gcagcatccc aagcgtgggt   3840

ctggtggagg agaacgagga caggcttatt gaccgcataa cactctacca gcatttaaaa   3900

tctagcctta atgaatacca gcccaaatta tatcaagtat tagatgatgg gaaacgactt   3960

ctgatatcca tcagctgctc agatctagaa agccaactaa atcaacttgg agagtgctgg   4020

ctaagtaaca ccaataaaat gtctaaggaa cttcacagac tggaaacaat attgaaacac   4080

tggaccagat atcaaagtga atctgcagat ctaattcact ggttacaatc tgcaaaagac   4140

cggctagaat tttggactca gcaatctgtg acagtcccac aagagctgga aatggtccgt   4200

gatcatctaa atgctttcct ggagttttct aaagaagtgg atgcccaatc ttccctgaaa   4260

tcatctgttc tgagtactgg aaatcagctc cttcgactaa aaaaggtgga cacagccacg   4320

ctgcgctctg agctgtcgcg cattgatagc cagtggactg acctgctaac caatatccca   4380

gccgtccagg agaagctcca ccagctccag atggataaac tgccttcccg ccatgccatt   4440

tctgaagtca tgagttggat ttctctaatg gaaaatgtta ttcagaagga tgaagataat   4500

attaaaaatt ccataggtta caaggcaatt catgaatacc ttcagaaata taagggtttt   4560

aagatagaca ttaactgtaa acagctgaca gtggattttg tgaaccagtc cgtgctacaa   4620

atcagcagtc aggatgtgga aagtaagcgt agtgataaga ctgattttgc tgagcaactt   4680

ggagcaatga ataaaagttg gcaaattctg caaggtctag taactgagaa gatccagctg   4740

ttggaaggct tattggaatc ttggtcagaa tatgaaaata atgtacaatg tctgaaaaca   4800

tggtttgaaa cccaggaaaa gagactaaaa caacagcatc gaattggaga tcaggcttct   4860

gttcaaaatg cactgaaaga ctgtcaggat ctggaagatt tgattaaagc aaaagaaaaa   4920

gaagtagaga aaattgagca gaatggactt gctttgattc agaacaagaa agaagacgtc   4980

tctagcattg tcatgagcac actgcgagag ctcggccaaa cctgggcaaa tttagatcac   5040

atggttggac aattaaagat actgctgaaa tcagtgcttg accaatggag tagtcacaaa   5100

gtggcctttg acaagataaa cagttacctc atggaggcca gatactctct ttcccgattc   5160

cgtctgctga ctggctcctt agaagctgtg caagttcagg tggacaatct tcagaatctc   5220

caagatgatc tggaaaaaca ggaaaggagc ttacagaaat ttggctctat caccaaccaa   5280

ttattaaaag agtgtcaccc acccgtgaca gaaactctta ccaatacact gaaagaagtc   5340

aacatgagat ggaataactt gctggaagag attgctgagc agctacagtc cagcaaggcc   5400

ctacttcagc tttggcaaag atacaaggac tactccaaac agtgtgcttc gacagttcag   5460

cagcaggagg atcgaaccaa tgagctgttg aaggcagcca caaacaagga cattgccgat   5520

gatgaggttg ccacatggat tcaagattgc aacgacctcc tcaaaggact gggcacagtt   5580

aaagattccc tcttttttct ccatgagctg ggagagcaac tgaagcaaca agtggatgct   5640

tccgcagcat cagctattca atcggatcaa ctctctttga gtcaacactt gtgtgccctg   5700

gagcaagctc tctgcaaaca gcagacttca ttacaggctg gagttcttga ttatgaaacc   5760

tttgccaaga gtttagaagc tttggaggcc tggatagtgg aagctgaaga aatactacaa   5820

gggcaggacc ctagccactc atctgacctc tccacaatcc aggaaaggat ggaagaactt   5880

aagggacaga tgttaaaatt cagcagcatg gctccagatt tagaccgtct aaatgagctt   5940

ggatataggt tacccttgaa tgataaggaa atcaaaagaa tgcagaatct gaaccgccat   6000

tggtctctga tctcctctca gactacagaa agattcagca agttgcagtc atttttgcta   6060

caacatcaga ctttcttgga aaaatgtgaa acatggatgg aattcctagt tcagacagaa   6120

caaaagttag cagtagagat ttcaggaaat tatcagcacc ttttggaaca gcagagagca   6180

cacgagttgt ttcaagccga gatgttcagt cgtcagcaga ttttgcactc aatcattatt   6240

gatgggcaac gtcttctaga acaaggtcaa gttgatgaca gggatgaatt caacctgaaa   6300

ttgacactcc tcagtaatca atggcaggga gtgattcgca gggcccagca gaggcggggg   6360

atcattgaca gccagattcg ccagtggcag cgctataggg agatggcaga aaagcttcgt   6420

aaatggttgg ttgaagtgtc ctacctcccc atgagtggtc tcggaagtgt tcctatacca   6480

ctgcaacaag caaggaccct ctttgatgaa gtgcagttca aagaaaaagt gtttctgcgg   6540

caacaaggca gctacatcct gactgtggag gctggcaagc aactccttct ctcggcggac   6600

agtggcgctg aggccgcctt gcaggccgaa ctcgctgaaa tccaagagaa atggaaatca   6660

gccagcatgc ggctggaaga acagaagaaa aaactagcct tcttgttgaa agactgggaa   6720

aaatgtgaga aaggaatagc agattccctg gagaaactac gaactttcaa aaagaagctt   6780

tcgcagtctc tcccggatca ccatgaagag ctccatgcag aacaaatgcg ttgcaaggaa   6840

ttagaaaatg cagttgggag ctggacagat gacttgaccc agttgagcct gctgaaggac   6900

accctctctg cctatatcag tgctgatgat atctccattc ttaatgaacg cgtagagctt   6960

ctgcaaaggc agtgggaaga actatgccac cagctctcct taaggcggca gcaaataggt   7020

gaaagattga atgaatgggc agtcttcagt gaaaagaaca aggaactctg tgagtggttg   7080

actcaaatgg aaagcaaagt ttctcagaat ggagacattc tcattgaaga aatgatagag   7140

aagctcaaga aggattatca agaggaaatt gctattgctc aagagaacaa aatacagctc   7200

caacaaatgg gagaacgact tgctaaagcc agccatgaaa gcaaagcatc tgagattgaa   7260

tacaagctgg gaaaggtcaa cgaccggtgg cagcatctcc tggacctcat tgcagccagg   7320

gtgaagaagc tgaaggagac cctggtagcc gtgcagcagc ttgataagaa catgagcagc   7380

ctgaggacct ggctcgctca catcgagtca gagctggcca agccaatagt ctacgattcc   7440

tgtaactcgg aagaaataca gagaaagctt aatgagcagc aggagcttca gagagacata   7500

gagaagcaca gtacaggtgt tgcatctgtc ctcaacctgt gtgaagtcct gctgcacgac   7560

tgtgacgcct gtgccactga tgccgagtgt gactctatac agcaggctac gagaaacctg   7620

gaccggcggt ggagaaacat ttgtgctatg tccatggaaa ggaggctgaa aatcgaagag   7680

acgtggcgat tgtggcagaa atttctggat gactattcac gttttgaaga ttggctgaag   7740

tcttcagaaa ggacagctgc ttttcccagc tcttctgggg tgatctatac agttgccaag   7800

gaagaactaa agaaatttga ggctttccag cgacaggtcc acgagtgcct gacgcagctg   7860

gaactgatca acaagcagta ccgccgcctg gccagggaga accgcactga ttcagcatgt   7920

agcctcaaac agatggttca cgaaggcaac cagagatggg acaacctgca aaagcgtgtc   7980

acctccatct tgcgcagact caagcatttt attggccagc gtgaggagtt tgagactgcg   8040

cgggacagca ttctggtctg gctcacagag atggatctgc agctcactaa tattgaacat   8100

ttttctgagt gtgatgttca agctaaaata aagcaactca aggccttcca gcaggaaatt   8160

tcactgaacc acaataagat tgagcagata attgcccaag gagaacagct gatagaaaag   8220

agtgagccct tggatgcagc gatcatcgag gaggaactag atgagctccg acggtactgc   8280

caggaggtct tcgggcgtgt ggaaagatac cataagaaac tgatccgcct gcctctccca   8340

gacgatgagc acgacctctc agacagggag ctggagctgg aagactctgc agctctgtcg   8400

gacctgcact ggcacgaccg ctctgcagac agcctgcttt ctccacagcc ttcctccaat   8460

ctctccctct cgctcgctca gcccctccgg agcgagcggt caggacgaga caccccggct   8520

agtgtggact ccatccccct ggagtgggat cacgactatg acctcagtcg ggacctggag   8580

tctgcaatgt ccagagctct gccctctgag gatgaagaag gtcaggatga caaagatttc   8640

tacctccggg gagctgttgg cttatcaggg gaccacagtg ccctagagtc acagatccga   8700

caactgggca aagccctgga tgatagccgt tttcagatac agcaaaccga aaatatcatt   8760

cgcagcaaaa ctcccacggg gccggagcta gacaccagct acaaaggcta catgaaactg   8820

ctgggcgaat gcagtagcag tatagactcc gtgaagagac tggagcacaa actgaaggag   8880

gaagaggaga gccttcctgg ctttgttaac ctgcatagta ccgaaaccca aacggctggt   8940

gtgattgacc gatgggagct tctccaggcc caggcattga gcaaggagtt gaggatgaag   9000

cagaacctcc agaagtggca gcagtttaac tcagacttga acagcatctg ggcctggctg   9060

ggggacacgg aggaggagtt ggaacagctc cagcgtctgg aactcagcac tgacatccag   9120

accatcgagc tccagatcaa aaagctcaag gagctccaga aagctgtgga ccaccgcaaa   9180

gccatcatcc tctccatcaa tctctgcagc cctgagttca cccaggctga cagcaaggag   9240

agccgggacc tgcaggatcg cttgtcgcag atgaatgggc gctgggaccg agtgtgctct   9300

ctgctggagg agtggcgggg cctgctgcag gatgccctga tgcagtgcca gggtttccat   9360

gaaatgagcc atggtttgct tcttatgctg gagaacattg acagaaggaa aaatgaaatt   9420

gtccctattg attctaacct tgatgcagag atacttcagg accatcacaa acagcttatg   9480

caaataaagc atgagctgtt ggaatcccaa ctcagagtag cctctttgca agacatgtct   9540

tgccaactac tggtgaatgc tgaaggaaca gactgtttag aagccaaaga aaaagtccat   9600

gttattggaa atcggctcaa acttctcttg aaggaggtca gtcgtcatat caaggaactg   9660

gagaagttat tagacgtgtc aagtagtcag caggatttgt cttcctggtc ttctgctgat   9720

gaactggaca cctcagggtc tgtgagtccc acatcaggaa ggagcacccc aaacagacag   9780

aaaacgccac gaggcaagtg tagtctctca cagcctggac cctctgtcag cagtccacat   9840

agcaggtcca caaaaggtgg ctccgattcc tccctttctg agccagggcc aggtcggtcc   9900

ggccgcggct tcctgttcag agtcctccga gcagctcttc cccttcagct tctcctgctc   9960

ctcctcatcg ggcttgcctg ccttgtacca atgtcagagg aagactacag ctgtgccctc  10020

tccaacaact ttgcccggtc attccacccc atgctcagat acacgaatgg ccctcctcca  10080

ctctgaacta agcagatgcc atctgcagaa gtgctggtag cataaggagg atcgggtcat  10140

aagcaatccc aaactaccaa caagaggacc ttgatcttgg cgaaagccct cggtgtggca  10200

gctttagccc tcctccagat cacatgtgtg caaattatgg cttcagaggt ggaagataaa  10260

cagtgacggg ggaacaaaca gacaacaaga aggtttggaa gaaatctggt ttgagactct  10320

gaaccttagc actaaggaga ttgagtaagg acctccaaag ttccccggac tcatgaattc  10380

tgggcccttg gcccattctg tgcacagcca aggacttcag tagaccatct gggcagcttt  10440

cccatggtgc tgctccaacc atcagataaa tgaccctccc aagcaccatg tcagtgtcgt  10500

acaatctacc aaccaaccag tgctgaagag attttagaac cttgtaacat acaattttta  10560

agagcttata tggcagcttc ctttttacct tgttttcctt tggggcatga tgttttaacc  10620

tttgctttag aagcacaagc tgtaaatcta aaaggcactt ttttttagag gtataaagaa  10680

aaactagatg taataaataa gatcatggaa ggctttatgt gaaaaaagtt gaatgttata  10740

gtaaaaaaaa aaagatattt atgtatgtac agtttgctaa agccaagttt tgtttgtatt  10800

gatttctttg catttattat agatattata aaata                             10835


<210>  385
<211>  3321
<212>  PRT
<213>  Homo sapiens

<400>  385

Met Glu Leu Asp Ala Ala Val Gln Lys Phe Leu Glu Gln Asn Gly Gln 
1               5                   10                  15


Leu Gly Lys Pro Leu Ala Lys Lys Ile Gly Lys Leu Thr Glu Leu His 
            20                  25                  30


Gln Gln Thr Ile Arg Gln Ala Glu Asn Arg Leu Ser Lys Leu Asn Gln 
        35                  40                  45


Ala Ala Ser His Leu Glu Glu Tyr Asn Glu Met Leu Glu Leu Ile Leu 
    50                  55                  60


Lys Trp Ile Glu Lys Ala Lys Val Leu Ala His Gly Thr Ile Ala Trp 
65                  70                  75                  80


Asn Ser Ala Ser Gln Leu Arg Glu Gln Tyr Ile Leu His Gln Thr Leu 
                85                  90                  95


Leu Glu Glu Ser Lys Glu Ile Asp Ser Glu Leu Glu Ala Met Thr Glu 
            100                 105                 110


Lys Leu Gln Tyr Leu Thr Ser Val Tyr Cys Thr Glu Lys Met Ser Gln 
        115                 120                 125


Gln Val Ala Glu Leu Gly Arg Glu Thr Glu Glu Leu Arg Gln Met Ile 
    130                 135                 140


Lys Ile Arg Leu Gln Asn Leu Gln Asp Ala Ala Lys Asp Met Lys Lys 
145                 150                 155                 160


Phe Glu Ala Glu Leu Lys Lys Leu Gln Ala Ala Leu Glu Gln Ala Gln 
                165                 170                 175


Ala Thr Leu Thr Ser Pro Glu Val Gly Arg Leu Ser Leu Lys Glu Gln 
            180                 185                 190


Leu Ser His Arg Gln His Leu Leu Ser Glu Met Glu Ser Leu Lys Pro 
        195                 200                 205


Lys Val Gln Ala Val Gln Leu Cys Gln Ser Ala Leu Arg Ile Pro Glu 
    210                 215                 220


Asp Val Val Ala Ser Leu Pro Leu Cys His Ala Ala Leu Arg Leu Gln 
225                 230                 235                 240


Glu Glu Ala Ser Arg Leu Gln His Thr Ala Ile Gln Gln Cys Asn Ile 
                245                 250                 255


Met Gln Ala Ala Val Val Gln Tyr Glu Gln Tyr Glu Gln Glu Met Lys 
            260                 265                 270


His Leu Gln Gln Leu Ile Glu Gly Ala His Arg Glu Ile Glu Asp Lys 
        275                 280                 285


Pro Val Ala Thr Ser Asn Ile Gln Glu Leu Gln Ala Gln Ile Ser Arg 
    290                 295                 300


His Glu Glu Leu Ala Gln Lys Ile Lys Gly Tyr Gln Glu Gln Ile Ala 
305                 310                 315                 320


Ser Leu Asn Ser Lys Cys Lys Met Leu Thr Met Lys Ala Lys His Ala 
                325                 330                 335


Thr Met Leu Leu Thr Val Thr Glu Val Glu Gly Leu Ala Glu Gly Thr 
            340                 345                 350


Glu Asp Leu Asp Gly Glu Leu Leu Pro Thr Pro Ser Ala His Pro Ser 
        355                 360                 365


Val Val Met Met Thr Ala Gly Arg Cys His Thr Leu Leu Ser Pro Val 
    370                 375                 380


Thr Glu Glu Ser Gly Glu Glu Gly Thr Asn Ser Glu Ile Ser Ser Pro 
385                 390                 395                 400


Pro Ala Cys Arg Ser Pro Ser Pro Val Ala Asn Thr Asp Ala Ser Val 
                405                 410                 415


Asn Gln Asp Ile Ala Tyr Tyr Gln Ala Leu Ser Ala Glu Arg Leu Gln 
            420                 425                 430


Thr Asp Ala Ala Lys Ile His Pro Ser Thr Ser Ala Ser Gln Glu Phe 
        435                 440                 445


Tyr Glu Pro Gly Leu Glu Pro Ser Ala Thr Ala Lys Leu Gly Asp Leu 
    450                 455                 460


Gln Arg Ser Trp Glu Thr Leu Lys Asn Val Ile Ser Glu Lys Gln Arg 
465                 470                 475                 480


Thr Leu Tyr Glu Ala Leu Glu Arg Gln Gln Lys Tyr Gln Asp Ser Leu 
                485                 490                 495


Gln Ser Ile Ser Thr Lys Met Glu Ala Ile Glu Leu Lys Leu Ser Glu 
            500                 505                 510


Ser Pro Glu Pro Gly Arg Ser Pro Glu Ser Gln Met Ala Glu His Gln 
        515                 520                 525


Ala Leu Met Asp Glu Ile Leu Met Leu Gln Asp Glu Ile Asn Glu Leu 
    530                 535                 540


Gln Ser Ser Leu Ala Glu Glu Leu Val Ser Glu Ser Cys Glu Ala Asp 
545                 550                 555                 560


Pro Ala Glu Gln Leu Ala Leu Gln Ser Thr Leu Thr Val Leu Ala Glu 
                565                 570                 575


Arg Met Ser Thr Ile Arg Met Lys Ala Ser Gly Lys Arg Gln Leu Leu 
            580                 585                 590


Glu Glu Lys Leu Asn Asp Gln Leu Glu Glu Gln Arg Gln Glu Gln Ala 
        595                 600                 605


Leu Gln Arg Tyr Arg Cys Glu Ala Asp Glu Leu Asp Ser Trp Leu Leu 
    610                 615                 620


Ser Thr Lys Ala Thr Leu Asp Thr Ala Leu Ser Pro Pro Lys Glu Pro 
625                 630                 635                 640


Met Asp Met Glu Ala Gln Leu Met Asp Cys Gln Asn Met Leu Val Glu 
                645                 650                 655


Ile Glu Gln Lys Val Val Ala Leu Ser Glu Leu Ser Val His Asn Glu 
            660                 665                 670


Asn Leu Leu Leu Glu Gly Lys Ala His Thr Lys Asp Glu Ala Glu Gln 
        675                 680                 685


Leu Ala Gly Lys Leu Arg Arg Leu Lys Gly Ser Leu Leu Glu Leu Gln 
    690                 695                 700


Arg Ala Leu His Asp Lys Gln Leu Asn Met Gln Gly Thr Ala Gln Glu 
705                 710                 715                 720


Lys Glu Glu Ser Asp Val Asp Leu Thr Ala Thr Gln Ser Pro Gly Val 
                725                 730                 735


Gln Glu Trp Leu Ala Gln Ala Arg Thr Thr Trp Thr Gln Gln Arg Gln 
            740                 745                 750


Ser Ser Leu Gln Gln Gln Lys Glu Leu Glu Gln Glu Leu Ala Glu Gln 
        755                 760                 765


Lys Ser Leu Leu Arg Ser Val Ala Ser Arg Gly Glu Glu Ile Leu Ile 
    770                 775                 780


Gln His Ser Ala Ala Glu Thr Ser Gly Asp Ala Gly Glu Lys Pro Asp 
785                 790                 795                 800


Val Leu Ser Gln Glu Leu Gly Met Glu Gly Glu Lys Ser Ser Ala Glu 
                805                 810                 815


Asp Gln Met Arg Met Lys Trp Glu Ser Leu His Gln Glu Phe Ser Thr 
            820                 825                 830


Lys Gln Lys Leu Leu Gln Asn Val Leu Glu Gln Glu Gln Glu Gln Val 
        835                 840                 845


Leu Tyr Ser Arg Pro Asn Arg Leu Leu Ser Gly Val Pro Leu Tyr Lys 
    850                 855                 860


Gly Asp Val Pro Thr Gln Asp Lys Ser Ala Val Thr Ser Leu Leu Asp 
865                 870                 875                 880


Gly Leu Asn Gln Ala Phe Glu Glu Val Ser Ser Gln Ser Gly Gly Ala 
                885                 890                 895


Lys Arg Gln Ser Ile His Leu Glu Gln Lys Leu Tyr Asp Gly Val Ser 
            900                 905                 910


Ala Thr Ser Thr Trp Leu Asp Asp Val Glu Glu Arg Leu Phe Val Ala 
        915                 920                 925


Thr Ala Leu Leu Pro Glu Glu Thr Glu Thr Cys Leu Phe Asn Gln Glu 
    930                 935                 940


Ile Leu Ala Lys Asp Ile Lys Glu Met Ser Glu Glu Met Asp Lys Asn 
945                 950                 955                 960


Lys Asn Leu Phe Ser Gln Ala Phe Pro Glu Asn Gly Asp Asn Arg Asp 
                965                 970                 975


Val Ile Glu Asp Thr Leu Gly Cys Leu Leu Gly Arg Leu Ser Leu Leu 
            980                 985                 990


Asp Ser Val Val Asn Gln Arg Cys His Gln Met Lys Glu Arg Leu Gln 
        995                 1000                1005


Gln Ile Leu Asn Phe Gln Asn Asp Leu Lys Val Leu Phe Thr Ser Leu 
    1010                1015                1020


Ala Asp Asn Lys Tyr Ile Ile Leu Gln Lys Leu Ala Asn Val Phe Glu 
1025                1030                1035                1040


Gln Pro Val Ala Glu Gln Ile Glu Ala Ile Gln Gln Ala Glu Asp Gly 
                1045                1050                1055


Leu Lys Glu Phe Asp Ala Gly Ile Ile Glu Leu Lys Arg Arg Gly Asp 
            1060                1065                1070


Lys Leu Gln Val Glu Gln Pro Ser Met Gln Glu Leu Ser Lys Leu Gln 
        1075                1080                1085


Asp Met Tyr Asp Glu Leu Met Met Ile Ile Gly Ser Arg Arg Ser Gly 
    1090                1095                1100


Leu Asn Gln Asn Leu Thr Leu Lys Ser Gln Tyr Glu Arg Ala Leu Gln 
1105                1110                1115                1120


Asp Leu Ala Asp Leu Leu Glu Thr Gly Gln Glu Lys Met Ala Gly Asp 
                1125                1130                1135


Gln Lys Ile Ile Val Ser Ser Lys Glu Glu Ile Gln Gln Leu Leu Asp 
            1140                1145                1150


Lys His Lys Glu Tyr Phe Gln Gly Leu Glu Ser His Met Ile Leu Thr 
        1155                1160                1165


Glu Thr Leu Phe Arg Lys Ile Ile Ser Phe Ala Val Gln Lys Glu Thr 
    1170                1175                1180


Gln Phe His Thr Glu Leu Met Ala Gln Ala Ser Ala Val Leu Lys Arg 
1185                1190                1195                1200


Ala His Lys Arg Gly Val Glu Leu Glu Tyr Ile Leu Glu Thr Trp Ser 
                1205                1210                1215


His Leu Asp Glu Asp Gln Gln Glu Leu Ser Arg Gln Leu Glu Val Val 
            1220                1225                1230


Glu Ser Ser Ile Pro Ser Val Gly Leu Val Glu Glu Asn Glu Asp Arg 
        1235                1240                1245


Leu Ile Asp Arg Ile Thr Leu Tyr Gln His Leu Lys Ser Ser Leu Asn 
    1250                1255                1260


Glu Tyr Gln Pro Lys Leu Tyr Gln Val Leu Asp Asp Gly Lys Arg Leu 
1265                1270                1275                1280


Leu Ile Ser Ile Ser Cys Ser Asp Leu Glu Ser Gln Leu Asn Gln Leu 
                1285                1290                1295


Gly Glu Cys Trp Leu Ser Asn Thr Asn Lys Met Ser Lys Glu Leu His 
            1300                1305                1310


Arg Leu Glu Thr Ile Leu Lys His Trp Thr Arg Tyr Gln Ser Glu Ser 
        1315                1320                1325


Ala Asp Leu Ile His Trp Leu Gln Ser Ala Lys Asp Arg Leu Glu Phe 
    1330                1335                1340


Trp Thr Gln Gln Ser Val Thr Val Pro Gln Glu Leu Glu Met Val Arg 
1345                1350                1355                1360


Asp His Leu Asn Ala Phe Leu Glu Phe Ser Lys Glu Val Asp Ala Gln 
                1365                1370                1375


Ser Ser Leu Lys Ser Ser Val Leu Ser Thr Gly Asn Gln Leu Leu Arg 
            1380                1385                1390


Leu Lys Lys Val Asp Thr Ala Thr Leu Arg Ser Glu Leu Ser Arg Ile 
        1395                1400                1405


Asp Ser Gln Trp Thr Asp Leu Leu Thr Asn Ile Pro Ala Val Gln Glu 
    1410                1415                1420


Lys Leu His Gln Leu Gln Met Asp Lys Leu Pro Ser Arg His Ala Ile 
1425                1430                1435                1440


Ser Glu Val Met Ser Trp Ile Ser Leu Met Glu Asn Val Ile Gln Lys 
                1445                1450                1455


Asp Glu Asp Asn Ile Lys Asn Ser Ile Gly Tyr Lys Ala Ile His Glu 
            1460                1465                1470


Tyr Leu Gln Lys Tyr Lys Gly Phe Lys Ile Asp Ile Asn Cys Lys Gln 
        1475                1480                1485


Leu Thr Val Asp Phe Val Asn Gln Ser Val Leu Gln Ile Ser Ser Gln 
    1490                1495                1500


Asp Val Glu Ser Lys Arg Ser Asp Lys Thr Asp Phe Ala Glu Gln Leu 
1505                1510                1515                1520


Gly Ala Met Asn Lys Ser Trp Gln Ile Leu Gln Gly Leu Val Thr Glu 
                1525                1530                1535


Lys Ile Gln Leu Leu Glu Gly Leu Leu Glu Ser Trp Ser Glu Tyr Glu 
            1540                1545                1550


Asn Asn Val Gln Cys Leu Lys Thr Trp Phe Glu Thr Gln Glu Lys Arg 
        1555                1560                1565


Leu Lys Gln Gln His Arg Ile Gly Asp Gln Ala Ser Val Gln Asn Ala 
    1570                1575                1580


Leu Lys Asp Cys Gln Asp Leu Glu Asp Leu Ile Lys Ala Lys Glu Lys 
1585                1590                1595                1600


Glu Val Glu Lys Ile Glu Gln Asn Gly Leu Ala Leu Ile Gln Asn Lys 
                1605                1610                1615


Lys Glu Asp Val Ser Ser Ile Val Met Ser Thr Leu Arg Glu Leu Gly 
            1620                1625                1630


Gln Thr Trp Ala Asn Leu Asp His Met Val Gly Gln Leu Lys Ile Leu 
        1635                1640                1645


Leu Lys Ser Val Leu Asp Gln Trp Ser Ser His Lys Val Ala Phe Asp 
    1650                1655                1660


Lys Ile Asn Ser Tyr Leu Met Glu Ala Arg Tyr Ser Leu Ser Arg Phe 
1665                1670                1675                1680


Arg Leu Leu Thr Gly Ser Leu Glu Ala Val Gln Val Gln Val Asp Asn 
                1685                1690                1695


Leu Gln Asn Leu Gln Asp Asp Leu Glu Lys Gln Glu Arg Ser Leu Gln 
            1700                1705                1710


Lys Phe Gly Ser Ile Thr Asn Gln Leu Leu Lys Glu Cys His Pro Pro 
        1715                1720                1725


Val Thr Glu Thr Leu Thr Asn Thr Leu Lys Glu Val Asn Met Arg Trp 
    1730                1735                1740


Asn Asn Leu Leu Glu Glu Ile Ala Glu Gln Leu Gln Ser Ser Lys Ala 
1745                1750                1755                1760


Leu Leu Gln Leu Trp Gln Arg Tyr Lys Asp Tyr Ser Lys Gln Cys Ala 
                1765                1770                1775


Ser Thr Val Gln Gln Gln Glu Asp Arg Thr Asn Glu Leu Leu Lys Ala 
            1780                1785                1790


Ala Thr Asn Lys Asp Ile Ala Asp Asp Glu Val Ala Thr Trp Ile Gln 
        1795                1800                1805


Asp Cys Asn Asp Leu Leu Lys Gly Leu Gly Thr Val Lys Asp Ser Leu 
    1810                1815                1820


Phe Phe Leu His Glu Leu Gly Glu Gln Leu Lys Gln Gln Val Asp Ala 
1825                1830                1835                1840


Ser Ala Ala Ser Ala Ile Gln Ser Asp Gln Leu Ser Leu Ser Gln His 
                1845                1850                1855


Leu Cys Ala Leu Glu Gln Ala Leu Cys Lys Gln Gln Thr Ser Leu Gln 
            1860                1865                1870


Ala Gly Val Leu Asp Tyr Glu Thr Phe Ala Lys Ser Leu Glu Ala Leu 
        1875                1880                1885


Glu Ala Trp Ile Val Glu Ala Glu Glu Ile Leu Gln Gly Gln Asp Pro 
    1890                1895                1900


Ser His Ser Ser Asp Leu Ser Thr Ile Gln Glu Arg Met Glu Glu Leu 
1905                1910                1915                1920


Lys Gly Gln Met Leu Lys Phe Ser Ser Met Ala Pro Asp Leu Asp Arg 
                1925                1930                1935


Leu Asn Glu Leu Gly Tyr Arg Leu Pro Leu Asn Asp Lys Glu Ile Lys 
            1940                1945                1950


Arg Met Gln Asn Leu Asn Arg His Trp Ser Leu Ile Ser Ser Gln Thr 
        1955                1960                1965


Thr Glu Arg Phe Ser Lys Leu Gln Ser Phe Leu Leu Gln His Gln Thr 
    1970                1975                1980


Phe Leu Glu Lys Cys Glu Thr Trp Met Glu Phe Leu Val Gln Thr Glu 
1985                1990                1995                2000


Gln Lys Leu Ala Val Glu Ile Ser Gly Asn Tyr Gln His Leu Leu Glu 
                2005                2010                2015


Gln Gln Arg Ala His Glu Leu Phe Gln Ala Glu Met Phe Ser Arg Gln 
            2020                2025                2030


Gln Ile Leu His Ser Ile Ile Ile Asp Gly Gln Arg Leu Leu Glu Gln 
        2035                2040                2045


Gly Gln Val Asp Asp Arg Asp Glu Phe Asn Leu Lys Leu Thr Leu Leu 
    2050                2055                2060


Ser Asn Gln Trp Gln Gly Val Ile Arg Arg Ala Gln Gln Arg Arg Gly 
2065                2070                2075                2080


Ile Ile Asp Ser Gln Ile Arg Gln Trp Gln Arg Tyr Arg Glu Met Ala 
                2085                2090                2095


Glu Lys Leu Arg Lys Trp Leu Val Glu Val Ser Tyr Leu Pro Met Ser 
            2100                2105                2110


Gly Leu Gly Ser Val Pro Ile Pro Leu Gln Gln Ala Arg Thr Leu Phe 
        2115                2120                2125


Asp Glu Val Gln Phe Lys Glu Lys Val Phe Leu Arg Gln Gln Gly Ser 
    2130                2135                2140


Tyr Ile Leu Thr Val Glu Ala Gly Lys Gln Leu Leu Leu Ser Ala Asp 
2145                2150                2155                2160


Ser Gly Ala Glu Ala Ala Leu Gln Ala Glu Leu Ala Glu Ile Gln Glu 
                2165                2170                2175


Lys Trp Lys Ser Ala Ser Met Arg Leu Glu Glu Gln Lys Lys Lys Leu 
            2180                2185                2190


Ala Phe Leu Leu Lys Asp Trp Glu Lys Cys Glu Lys Gly Ile Ala Asp 
        2195                2200                2205


Ser Leu Glu Lys Leu Arg Thr Phe Lys Lys Lys Leu Ser Gln Ser Leu 
    2210                2215                2220


Pro Asp His His Glu Glu Leu His Ala Glu Gln Met Arg Cys Lys Glu 
2225                2230                2235                2240


Leu Glu Asn Ala Val Gly Ser Trp Thr Asp Asp Leu Thr Gln Leu Ser 
                2245                2250                2255


Leu Leu Lys Asp Thr Leu Ser Ala Tyr Ile Ser Ala Asp Asp Ile Ser 
            2260                2265                2270


Ile Leu Asn Glu Arg Val Glu Leu Leu Gln Arg Gln Trp Glu Glu Leu 
        2275                2280                2285


Cys His Gln Leu Ser Leu Arg Arg Gln Gln Ile Gly Glu Arg Leu Asn 
    2290                2295                2300


Glu Trp Ala Val Phe Ser Glu Lys Asn Lys Glu Leu Cys Glu Trp Leu 
2305                2310                2315                2320


Thr Gln Met Glu Ser Lys Val Ser Gln Asn Gly Asp Ile Leu Ile Glu 
                2325                2330                2335


Glu Met Ile Glu Lys Leu Lys Lys Asp Tyr Gln Glu Glu Ile Ala Ile 
            2340                2345                2350


Ala Gln Glu Asn Lys Ile Gln Leu Gln Gln Met Gly Glu Arg Leu Ala 
        2355                2360                2365


Lys Ala Ser His Glu Ser Lys Ala Ser Glu Ile Glu Tyr Lys Leu Gly 
    2370                2375                2380


Lys Val Asn Asp Arg Trp Gln His Leu Leu Asp Leu Ile Ala Ala Arg 
2385                2390                2395                2400


Val Lys Lys Leu Lys Glu Thr Leu Val Ala Val Gln Gln Leu Asp Lys 
                2405                2410                2415


Asn Met Ser Ser Leu Arg Thr Trp Leu Ala His Ile Glu Ser Glu Leu 
            2420                2425                2430


Ala Lys Pro Ile Val Tyr Asp Ser Cys Asn Ser Glu Glu Ile Gln Arg 
        2435                2440                2445


Lys Leu Asn Glu Gln Gln Glu Leu Gln Arg Asp Ile Glu Lys His Ser 
    2450                2455                2460


Thr Gly Val Ala Ser Val Leu Asn Leu Cys Glu Val Leu Leu His Asp 
2465                2470                2475                2480


Cys Asp Ala Cys Ala Thr Asp Ala Glu Cys Asp Ser Ile Gln Gln Ala 
                2485                2490                2495


Thr Arg Asn Leu Asp Arg Arg Trp Arg Asn Ile Cys Ala Met Ser Met 
            2500                2505                2510


Glu Arg Arg Leu Lys Ile Glu Glu Thr Trp Arg Leu Trp Gln Lys Phe 
        2515                2520                2525


Leu Asp Asp Tyr Ser Arg Phe Glu Asp Trp Leu Lys Ser Ser Glu Arg 
    2530                2535                2540


Thr Ala Ala Phe Pro Ser Ser Ser Gly Val Ile Tyr Thr Val Ala Lys 
2545                2550                2555                2560


Glu Glu Leu Lys Lys Phe Glu Ala Phe Gln Arg Gln Val His Glu Cys 
                2565                2570                2575


Leu Thr Gln Leu Glu Leu Ile Asn Lys Gln Tyr Arg Arg Leu Ala Arg 
            2580                2585                2590


Glu Asn Arg Thr Asp Ser Ala Cys Ser Leu Lys Gln Met Val His Glu 
        2595                2600                2605


Gly Asn Gln Arg Trp Asp Asn Leu Gln Lys Arg Val Thr Ser Ile Leu 
    2610                2615                2620


Arg Arg Leu Lys His Phe Ile Gly Gln Arg Glu Glu Phe Glu Thr Ala 
2625                2630                2635                2640


Arg Asp Ser Ile Leu Val Trp Leu Thr Glu Met Asp Leu Gln Leu Thr 
                2645                2650                2655


Asn Ile Glu His Phe Ser Glu Cys Asp Val Gln Ala Lys Ile Lys Gln 
            2660                2665                2670


Leu Lys Ala Phe Gln Gln Glu Ile Ser Leu Asn His Asn Lys Ile Glu 
        2675                2680                2685


Gln Ile Ile Ala Gln Gly Glu Gln Leu Ile Glu Lys Ser Glu Pro Leu 
    2690                2695                2700


Asp Ala Ala Ile Ile Glu Glu Glu Leu Asp Glu Leu Arg Arg Tyr Cys 
2705                2710                2715                2720


Gln Glu Val Phe Gly Arg Val Glu Arg Tyr His Lys Lys Leu Ile Arg 
                2725                2730                2735


Leu Pro Leu Pro Asp Asp Glu His Asp Leu Ser Asp Arg Glu Leu Glu 
            2740                2745                2750


Leu Glu Asp Ser Ala Ala Leu Ser Asp Leu His Trp His Asp Arg Ser 
        2755                2760                2765


Ala Asp Ser Leu Leu Ser Pro Gln Pro Ser Ser Asn Leu Ser Leu Ser 
    2770                2775                2780


Leu Ala Gln Pro Leu Arg Ser Glu Arg Ser Gly Arg Asp Thr Pro Ala 
2785                2790                2795                2800


Ser Val Asp Ser Ile Pro Leu Glu Trp Asp His Asp Tyr Asp Leu Ser 
                2805                2810                2815


Arg Asp Leu Glu Ser Ala Met Ser Arg Ala Leu Pro Ser Glu Asp Glu 
            2820                2825                2830


Glu Gly Gln Asp Asp Lys Asp Phe Tyr Leu Arg Gly Ala Val Gly Leu 
        2835                2840                2845


Ser Gly Asp His Ser Ala Leu Glu Ser Gln Ile Arg Gln Leu Gly Lys 
    2850                2855                2860


Ala Leu Asp Asp Ser Arg Phe Gln Ile Gln Gln Thr Glu Asn Ile Ile 
2865                2870                2875                2880


Arg Ser Lys Thr Pro Thr Gly Pro Glu Leu Asp Thr Ser Tyr Lys Gly 
                2885                2890                2895


Tyr Met Lys Leu Leu Gly Glu Cys Ser Ser Ser Ile Asp Ser Val Lys 
            2900                2905                2910


Arg Leu Glu His Lys Leu Lys Glu Glu Glu Glu Ser Leu Pro Gly Phe 
        2915                2920                2925


Val Asn Leu His Ser Thr Glu Thr Gln Thr Ala Gly Val Ile Asp Arg 
    2930                2935                2940


Trp Glu Leu Leu Gln Ala Gln Ala Leu Ser Lys Glu Leu Arg Met Lys 
2945                2950                2955                2960


Gln Asn Leu Gln Lys Trp Gln Gln Phe Asn Ser Asp Leu Asn Ser Ile 
                2965                2970                2975


Trp Ala Trp Leu Gly Asp Thr Glu Glu Glu Leu Glu Gln Leu Gln Arg 
            2980                2985                2990


Leu Glu Leu Ser Thr Asp Ile Gln Thr Ile Glu Leu Gln Ile Lys Lys 
        2995                3000                3005


Leu Lys Glu Leu Gln Lys Ala Val Asp His Arg Lys Ala Ile Ile Leu 
    3010                3015                3020


Ser Ile Asn Leu Cys Ser Pro Glu Phe Thr Gln Ala Asp Ser Lys Glu 
3025                3030                3035                3040


Ser Arg Asp Leu Gln Asp Arg Leu Ser Gln Met Asn Gly Arg Trp Asp 
                3045                3050                3055


Arg Val Cys Ser Leu Leu Glu Glu Trp Arg Gly Leu Leu Gln Asp Ala 
            3060                3065                3070


Leu Met Gln Cys Gln Gly Phe His Glu Met Ser His Gly Leu Leu Leu 
        3075                3080                3085


Met Leu Glu Asn Ile Asp Arg Arg Lys Asn Glu Ile Val Pro Ile Asp 
    3090                3095                3100


Ser Asn Leu Asp Ala Glu Ile Leu Gln Asp His His Lys Gln Leu Met 
3105                3110                3115                3120


Gln Ile Lys His Glu Leu Leu Glu Ser Gln Leu Arg Val Ala Ser Leu 
                3125                3130                3135


Gln Asp Met Ser Cys Gln Leu Leu Val Asn Ala Glu Gly Thr Asp Cys 
            3140                3145                3150


Leu Glu Ala Lys Glu Lys Val His Val Ile Gly Asn Arg Leu Lys Leu 
        3155                3160                3165


Leu Leu Lys Glu Val Ser Arg His Ile Lys Glu Leu Glu Lys Leu Leu 
    3170                3175                3180


Asp Val Ser Ser Ser Gln Gln Asp Leu Ser Ser Trp Ser Ser Ala Asp 
3185                3190                3195                3200


Glu Leu Asp Thr Ser Gly Ser Val Ser Pro Thr Ser Gly Arg Ser Thr 
                3205                3210                3215


Pro Asn Arg Gln Lys Thr Pro Arg Gly Lys Cys Ser Leu Ser Gln Pro 
            3220                3225                3230


Gly Pro Ser Val Ser Ser Pro His Ser Arg Ser Thr Lys Gly Gly Ser 
        3235                3240                3245


Asp Ser Ser Leu Ser Glu Pro Gly Pro Gly Arg Ser Gly Arg Gly Phe 
    3250                3255                3260


Leu Phe Arg Val Leu Arg Ala Ala Leu Pro Leu Gln Leu Leu Leu Leu 
3265                3270                3275                3280


Leu Leu Ile Gly Leu Ala Cys Leu Val Pro Met Ser Glu Glu Asp Tyr 
                3285                3290                3295


Ser Cys Ala Leu Ser Asn Asn Phe Ala Arg Ser Phe His Pro Met Leu 
            3300                3305                3310


Arg Tyr Thr Asn Gly Pro Pro Pro Leu 
        3315                3320


<210>  386
<211>  27436
<212>  DNA
<213>  Homo sapiens

<400>  386
cggccgccgg ccgcagcggg ctgagattgt tgtcctctgt caccagggcg gctgggctcc     60

cgcagtcctg cagaccgcgc ccgatcccgg cgacagggcg ggcggacagc cgcgcatccc    120

cggggtcccg ccgagcctgg gcgcagagag ccgggaggaa gcgttcgctc gcttcgcctt    180

gctgctggga aactgaacga ggccgagaga gaaggttctt gagttcatgt aagaggacag    240

tcttaaaacg gaagaagaaa aagaagcagt tcagtctttg ggagagctgc ctccttgttg    300

agtgctgcaa aggcctggaa ttcatttatg acagaataga tctagaaaag tccaagcatg    360

ttttctagag tggtgtagcc ctgtgctgcc tccagtgaag agtctcttgg tgttggcttc    420

gtgcttccgg agggaccatg gcaacctcca gaggggcctc ccggtgtcct cgggatatcg    480

ccaatgtgat gcagaggctg caagatgagc aagagatagt acaaaaacga actttcacaa    540

aatggatcaa ctctcatctg gccaagcgga aacctccaat ggtggtggac gatctttttg    600

aagacatgaa agatggtgtt aaactgcttg cccttctgga ggtcctgtct gggcagaaac    660

tgccttgtga acaaggacgc cggatgaagc gaatccatgc tgtggctaac attggcacgg    720

cactcaagtt cctcgaagga agaaagtcca tgcacagagg atcaccgatt aaattagtca    780

acattaactc caccgatata gctgatggcc gaccctcaat agttcttgga ttgatgtgga    840

ccattattct atatttccag attgaagagt tgaccagcaa cctgccccag ctccagtctt    900

tgtccagcag cgcatcctcc gtggacagca tagttagctc tgagactccc agcccaccaa    960

gtaaacggaa ggtgaccacc aagatccaag gaaatgctaa gaaggcttta ttaaagtggg   1020

ttcagtacac agctggcaag cagactggaa tagaagtaaa agattttggg aagagttgga   1080

gaagcggggt tgcctttcat tcagttattc atgccattcg accggaattg gtggacttgg   1140

agacagtgaa aggcagatcc aaccgagaaa atttggagga tgctttcact atcgccgaaa   1200

cagaactggg gatcccaaga ctgctagatc ctgaagacgt tgatgtggat aaaccagatg   1260

agaaatctat tatgacctat gtagcccagt ttctgaaaca ttatcctgac atccacaatg   1320

caagcactga tgggcaagag gatgatgaaa tacttccagg tttcccatct tttgcaaatt   1380

ctgtacaaaa ttttaagaga gaagacagag taatttttaa ggaaatgaaa gtttggatag   1440

aacaatttga gagagatttg acaagagcac agatggtgga atcaaattta caggataaat   1500

atcagtcatt taagcacttc agagttcaat atgaaatgaa gaggaaacag attgaacatt   1560

taatacaacc attacacaga gacggtaaat tgtcacttga ccaagcattg gtaaaacaat   1620

cttgggatag agtgacctcc aggctctttg actggcatat acagcttgat aaatctcttc   1680

ctgcacctct gggcaccata ggtgcctggc tgtacagagc ggaggtggcc ctgagagagg   1740

aaataaccgt tcaacaggtc cacgaggaaa cagcaaacac gatacaacgg aaacttgagc   1800

aacataagga tctgcttcaa aacacggatg cccacaaaag agcattccat gaaatctacc   1860

ggaccaggtc tgttaacggg attccagtgc cacctgatca attagaggac atggccgaga   1920

ggtttcattt tgtttcctcc acatcagagc tacacctaat gaaaatggaa tttttagaat   1980

taaagtaccg tctgctctca ctgctggttc ttgcagagtc aaagctgaag tcttggatca   2040

ttaagtacgg gaggagagag tcagtggagc agcttctaca aaactacgtg tcttttatag   2100

aaaatagcaa gttctttgaa caatatgagg tgacatacca gatcttgaaa cagacagctg   2160

agatgtatgt caaagcagat ggttcagtgg aagaagctga gaatgtgatg aaattcatga   2220

atgaaaccac cgctcagtgg aggaatctct cagtagaagt gaggagtgtg aggagcatgc   2280

tggaagaagt gatctctaac tgggatcgct atggcaatac agtggctagt ctgcaagcct   2340

ggctagagga tgctgaaaaa atgctcaatc aatcagaaaa tgccaaaaag gatttttttc   2400

gaaatttacc tcattggatt cagcagcata ctgccatgaa cgatgctggc aattttctaa   2460

ttgaaacctg tgatgagatg gtttcccgtg acctgaagca gcaattactg ttgctaaatg   2520

ggcggtggag ggagttgttt atggaagtca agcaatatgc tcaagctgat gagatggaca   2580

gaatgaagaa ggaatacaca gactgtgttg ttaccctgtc tgcttttgca acggaagccc   2640

ataagaaact ttctgaaccc ttagaagtct cttttatgaa tgtcaagcta ttaattcaag   2700

acttggagga tattgagcag agggtgcctg tgatggatgc ccaatacaag ataattacaa   2760

agacagcaca cctcattacc aaagaaagcc cccaagaaga aggaaaagaa atgtttgcga   2820

ccatgtcaaa gctcaaagag cagctaacca aggtcaaaga atgttactcc ccactccttt   2880

atgagtctca gcagctgttg attccgttgg aggaattaga aaagcagatg acgtcctttt   2940

atgactcact tgggaaaatc aatgaaatta tcacagttct tgagcgtgag gcacaatcga   3000

gtgccctttt taaacaaaaa catcaggaac tgttagcttg tcaagaaaac tgtaagaaaa   3060

ccttgacact tattgagaaa ggcagtcaaa gtgttcaaaa gtttgtgacc ttgagcaacg   3120

tgttaaagca ttttgatcag acgaggctac aaagacagat tgcagatatt catgttgctt   3180

ttcagagtat ggtaaagaaa actggagatt ggaagaagca tgtggaaacc aacagtcgct   3240

tgatgaagaa gtttgaggag tctcgagcag agttggagaa ggtactgcgg attgctcagg   3300

agggcctgga ggaaaagggg gatccagagg agctcctgcg gagacacact gagtttttca   3360

gtcagctgga tcagagggtg ctcaatgctt tcctgaaagc ttgtgatgaa ctcaccgaca   3420

tccttccaga gcaggagcag caggggctgc aggaagctgt tcgaaagctc cacaaacaat   3480

ggaaggatct tcaaggagaa gccccttatc atttgcttca tctgaagatt gatgtggaga   3540

agaataggtt cttagcctct gtagaagaat gcagaactga gctggatcga gagaccaagc   3600

tgatgcccca ggaaggcagt gaaaagataa ttaaagagca cagggttttc ttcagtgaca   3660

aaggtcctca tcatctctgt gagaaaaggt tacagctcat cgaggaactc tgtgtgaaac   3720

tcccagtgcg ggacccagta agggacacac ctggaacctg tcacgtgact ctcaaagagc   3780

tcagagctgc cattgacagc acctacagga agctcatgga agacccagac aagtggaagg   3840

actacactag cagattctct gagttctcat cttggatatc tacaaatgag acacaattaa   3900

aggggatcaa gggtgaggcc atcgatactg ccaaccacgg agaggttaaa cgtgccgttg   3960

aagagatcag aaatggtgtt accaaaaggg gtgagaccct cagctggctg aaatccaggc   4020

tgaaagtttt gacagaagtt tcttctgaga atgaagccca aaagcaggga gatgagctgg   4080

caaaattatc cagctctttc aaggctcttg tgacgctgct gtcagaggtt gaaaagatgc   4140

taagcaattt tggggactgt gtccagtaca aagaaatagt caaaaattct ctcgaagaat   4200

taatttctgg ctctaaagaa gtccaggaac aagctgagaa gatcttggat actgaaaatc   4260

tgtttgaagc acagcagtta cttcttcatc accagcaaaa gacaaagcgg atctcagcaa   4320

agaagagaga tgtgcagcag cagatcgcgc aggcgcagca gggagaaggg gggctgcctg   4380

accgaggcca cgaggagctg cggaagctgg agagcacact ggatggcctg gagcgcagcc   4440

gggagaggca ggaacgccgc atccaggtca cattaagaaa atgggagcga tttgaaacaa   4500

acaaagaaac agtagtaaga tacctttttc aaacaggttc cagtcatgaa cgcttcttga   4560

gttttagcag tttggaaagt ttatcttcag aactggaaca aacaaaggag ttttctaaac   4620

ggacagaaag tattgcagtc caggctgaga accttgtaaa ggaagcttca gagataccgc   4680

ttgggcccca aaataagcag ctgcttcaac agcaggccaa gtcaatcaaa gaacaagtca   4740

aaaaattaga agacacgctt gaagaagata ttaaaaccat ggaaatggtg aaaaccaagt   4800

gggatcattt tggcagtaat tttgagactc tgtccgtctg gataactgag aaagaaaaag   4860

aactcaatgc cttggaaact tcgtcatctg ccatggacat gcaaatcagc caaattaagg   4920

tcacaattca ggaaatagaa agtaagctca gcagcattgt aggattagaa gaagaagccc   4980

agtcttttgc tcagtttgtt accactggag aatctgctcg aattaaagcc aagttgacac   5040

aaataagaag atacggggaa gagcttcgag agcatgcaca gtgtctggaa ggaacaatcc   5100

tgggacattt atctcagcag caaaagtttg aagagaacct tagaaagatc cagcaatctg   5160

tgtctgaatt tgaagataaa cttgctgttc caattaaaat atgttcttca gctacagaaa   5220

catacaaagt tcttcaagaa catatggatc tctgccaggc cctggagtca ctgagcagcg   5280

cgatcactgc cttctcagcc agtgccagga aggttgtgaa cagagattcc tgtgttcagg   5340

aggctgcggc tctacagcag caatacgagg acatcctaag gagggcgaag gagagacaga   5400

cggcgctgga gaatctgctg gcccactggc agaggctaga gaaagaacta tcatcctttt   5460

tgacctggtt agagcggggt gaagctaaag ccagttcccc agaaatggac atttctgcag   5520

acagagtcaa agtggaaggt gaacttcagt taatacaggc actgcaaaat gaagttgtat   5580

cccaggcctc attctatagc aaacttttgc aattgaagga atcattgttc tcagtagcct   5640

ccaaagatga tgtgaaaatg atgaaactac atttggagca gttggatgag agatggagag   5700

atttaccaca gatcattaac aaaaggatta attttcttca gtctgtggtt gctgaacacc   5760

agcaatttga tgagctgctg ctttcctttt ctgtctggat taaactgttt ctcagtgaat   5820

tacaaactac ctctgagatt agcataatgg accatcaagt agcccttact cggcataagg   5880

accacgcagc agaagtagag agcaaaaagg gcgaattgca gagtctgcag ggtcacttag   5940

caaagttggg ttctctgggc cgtgctgagg acctccacct cctgcaggga aaggctgagg   6000

actgcttcca gctgtttgag gaggccagcc aggttgtgga gaggcggcag cttgccctgt   6060

cccatttggc agaattcctc cagagccatg cctctctgtc cggcattctc cgccagctga   6120

ggcaaacagt ggaagcaacc aacagtatga ataagaacga gtctgatttg atagaaaagg   6180

acctcaatga tgctcttcaa aatgctaaag cattagaatc tgctgccgtc agtctggatg   6240

gcattctttc caaagcccaa taccatctga aaatcgggag ctctgagcaa aggacttcct   6300

gcagagccac ggctgatcag ctctgtggag aggtagagag gatccagaac cttctgggaa   6360

ccaagcagag tgaggcagat gctctggcag tgttgaaaaa agcattccaa gaccagaaag   6420

aggagcttct gaaaagcatt gaggacattg aagaaaggac tgacaaagag cgattgaaag   6480

aacctacccg ccaagctctt cagcagaggt taagagtgtt taatcagcta gaagatgaat   6540

tgaattctca cgagcatgaa ctatgttggt tgaaagacaa agccaagcaa attgcccaga   6600

aagatgtagc ttttgcacct gaagttgaca gggagataaa ccgcttagag gtcacctggg   6660

atgataccaa aagactaatt catgaaaatc agggtcagtg ctgtggactt attgacttaa   6720

tgagagaata tcagaacctg aaatcagctg tatctaaagt cttagaaaat gccagcagtg   6780

tgattgtaac cagaactacc ataaaagatc aggaggatct taaatgggct ttttccaagc   6840

atgaaactgc caagaacaaa atgaattaca aacagaaaga cttggataac tttaccagca   6900

aaggaaaaca cttgttatct gagctgaaga aaattcacag tagtgatttc agcttggtga   6960

aaacagacat ggagagcacc gtggacaaat ggctggatgt atcagagaaa cttgaagaaa   7020

acatggatag gctgagagta agcctgtcca tttgggatga tgtactgtca actagagatg   7080

agattgaggg atggtcaaac aactgcgttc cacagatggc agaaaacatc agcaacctgg   7140

ataaccacct cagagctgaa gaactgctta aagaatttga gtctgaagtt aaaaacaaag   7200

cattgagatt ggaagaactg cattccaaag ttaatgatct gaaagaatta actaaaaatc   7260

tagaaacacc gccagacctt cagtttatag aagcagactt aatgcagaaa ctggagcatg   7320

ccaaagaaat aactgaagta gcaaaaggaa ccctgaagga tttcacggct caaagtacac   7380

aagtggagaa gtttattaat gacataacaa catggttcac aaaagtggaa gaatcgttga   7440

tgaactgtgc ccaaaatgag acttgtgaag cattgaaaaa agtcaaggat atacaaaaag   7500

aacttcaaag tcaacaaagc aacatcagct ctacccaaga aaatctcaat agcttgtgcc   7560

gcaagtacca ctcagctgag ttggagagcc tgggccgtgc aatgactggt ctgataaaga   7620

aacatgaagc cgtgagccag ttgtgctcca aaacccaggc cagcctgcag gaatctctgg   7680

aaaaacactt cagtgagtct atgcaggaat tccaagaatg gtttttggga gcaaaggcag   7740

cagcaaaaga atcatcagat cgcaccggtg acagcaaagt tctagaagca aagctccatg   7800

atcttcagaa cattttggac tcagtcagtg atgggcagag caaacttgat gcagtgactc   7860

aagaaggaca aactttgtat gcacatttgt ctaaacaaat tgtcagtagc attcaagaac   7920

aaatcacaaa ggccaatgaa gagtttcaag catttctgaa acaatgcctt aaagataagc   7980

aggctcttca agactgtgct tcagaacttg gaagctttga agatcagcac agaaaactga   8040

acttatggat ccatgaaatg gaagaaaggt tcaatacgga aaacttggga gagagtaaac   8100

agcacattcc tgagaagaaa aatgaagttc ataaagttga aatgtttttg ggagaactgc   8160

tggctgcaag agagtctctt gataagcttt cccagagagg gcagcttctg agtgaagaag   8220

gccacggtgc tgggcaggag ggccgcctgt gttcccagct cctcacaagc caccagaacc   8280

tacttagaat gaccaaagag aaactccgga gctgccaggt ggcccttcag gagcacgaag   8340

ccctggagga agcactgcaa agcatgtggt tctgggtgaa ggccattcag gacagactgg   8400

cctgtgcaga gagcactctt gggagcaaag acaccctgga gaaacggctg tcacaaatac   8460

aggatattct cctgatgaaa ggtgaagggg aagttaagtt gaatatggcc attggcaagg   8520

gggaacaggc cttgagaagt agcaacaaag aaggtcagag ggtgattcag actcagttag   8580

agacccttaa agaagtgtgg gctgacatca tgagctcctc cgtccacgct caaagcactt   8640

tagagtctgt gattagccaa tggaatgact atgtagagag gaaaaaccag ttggagcagt   8700

ggatggaatc agtggatcaa aaaatagaac atcccttaca accacagcca ggtctgaaag   8760

agaagttcgt cctgcttgac cacctccagt ccatcctgtc tgaggcagaa gatcacacga   8820

gagcccttca ccgtctaatt gcgaagtcca gggagctcta cgaaaagaca gaggatgagt   8880

ctttcaagga cacagctcaa gaggagctga aaacacagtt taatgatata atgactgttg   8940

ccaaggaaaa aatgaggaaa gtggaagaga ttgtgaaaga tcatctaatg tatttagatg   9000

cggtccacga gttcacagat tggctccatt cagcaaagga agaacttcac cggtggtcag   9060

atatgtctgg agattcatca gccacccaga aaaagttatc aaaaattaag gagctgatag   9120

attccagaga gattggtgca agccgtctca gcagagtgga gtcgctggct cccgaagtga   9180

aacagaacac aactgccagt gggtgtgagc tcatgcacac ggagatgcag gccctgcgtg   9240

ccgactggaa gcagtgggaa gacagtgtat tccaaacgca gagctgtttg gagaacctgg   9300

tcagccagat ggccctttcg gagcaggaat tctcaggcca agtggctcaa ctggagcagg   9360

ccctggaaca gttcagtgcc cttctgaaaa cctgggctca gcagttaacc ctcctggaag   9420

gcaagaacac ggatgaggag atagtggaat gctggcacaa aggacaagag atactggatg   9480

ctttgcaaaa agcagagcct agaacagagg atctcaagtc tcagctgaat gaactttgtc   9540

gattttccag agacctgagt acctacagtg gaaaagtttc tggcttgatt aaagagtata   9600

attgtctttg tttgcaagca tccaagggct gccagaataa agaacagatt ttacagcaaa   9660

gatttcgaaa ggccttcagg gatttccagc agtggttggt taatgcaaaa atcactaccg   9720

ccaagtgttt tgatatacct caaaatataa gtgaagtttc aactagtctt cagaaaatac   9780

aggagttttt gtcagaaagt gaaaatggac agcacaagct aaacatgatg ctgtctaaag   9840

gggaacttct gagtaccctg ctgaccaaag agaaagcgaa agggatccag gccaaagtta   9900

cagctgcaaa agaagattgg aaaaattttc attcaaatct ccaccaaaaa gaatctgctc   9960

tagagaatct aaagatccaa atgaaggact ttgaagtaag tgctgagcct atccaggact  10020

ggctgagtaa aactgagaag atggtccatg aaagcagcaa tcgcctctat gatctgccag  10080

caaagaggag ggagcagcag aagctccagt ctgtccttga ggaaatacac tgctacgagc  10140

ctcagctcaa caggctgaaa gagaaagctc agcagctgtg ggaaggacaa gctgccagca  10200

agagctttag gcacagagtg tcgcagctgt cttctcagta tctagcgcta agcaatttaa  10260

caaaggagaa agtgtcaaga ctggatagaa tcgttgcaga acacaatcag ttctctcttg  10320

ggattaaaga attacaagac tggatgacgg atgcgattca catgctggat tcatactgcc  10380

acccgacatc cgacaaaagt gtgctggaca gcaggacgct caagctcgag gctctattat  10440

cagtcaaaca ggaaaaagag attcagatga aaatgatagt gaccagggga gaatctgtcc  10500

ttcagaatac ttctccagaa ggcattccca ctattcagca gcagctgcag agtgtgaagg  10560

atatgtgggc atcccttttg tctgcaggga ttcgttgtaa aagccaactc gaaggagctc  10620

tctccaagtg gacaagttat caggatggcg ttcgacagtt ctccggttgg atggatagta  10680

tggaagccaa cctgaatgaa tcagaaaggc agcatgcgga gctgcgggat aaaacaacga  10740

tgctcggaaa agccaagtta ttaaatgaag aagtgctgag ttacagcagc ttgctggaga  10800

ccatcgaagt caaaggggct ggcatgacag aacactatgt cacccagcta gaactccagg  10860

atctacagga acgatacaga gccatccaag agagggccaa ggaagccgta accaagtctg  10920

aaaaacttgt ccgcctgcac caagagtatc agagagacct aaaggcattt gaagtttggt  10980

tggggcaaga acaagaaaag ctcgaccagt attcagttct tgaaggtgat gcccacactc  11040

atgagacaac attgcgtgat cttcaggagc tacaggtaca ctgtgcagag gggcaggccc  11100

tgttgaactc agtgctgcac accagagagg atgtgatccc atcaggtatc ccacaggcag  11160

aggaccgggc tttagagtct ctccggcaag actggcaggc ttaccagcac aggctgtccg  11220

agactcgaac tcagttcaat aacgtggtga acaaattgag gctaatggag caaaagtttc  11280

agcaagtaga tgaatggctc aaaacagcag aggagaaaaa gtggcacgaa gaagtgactg  11340

catacagaga tgaagttgag gaagtgggag ctagagctca ggagatactg gacgagagcc  11400

acgtgaacag cagaatgggt tgccaggcca cccagctgac ttccagatac caggccctgc  11460

ttctccaagt gctggaacaa ataaaattcc tggaggagga gattcagagt ttggaggaat  11520

cagaatcatc cctcagttcc tattctgatt ggtatggctc tactcataaa aacttcaaga  11580

atgtggctac caagattgac aaagtagata cagtaatgat ggggaagaaa ttgaagacgt  11640

tggaggtttt gctcaaagac atggagaaag gtcacagttt gctgaaatca gcccgggaga  11700

aaggagagag ggctgttaaa tacttggagg aaggcgaggc agagaggtta agaaaggaga  11760

ttcatgatca catggagcag ttgaaggaac tgaccagcac tgtccggaaa gaacacatga  11820

cgctggaaaa aggtcttcat ttagcaaagg aattctcaga taaatgcaaa gcactgacac  11880

agtggatagc agaataccag gaaattctac atgttcctga agaacccaaa atggaattat  11940

atgagaaaaa agctcagtta tctaaataca agtcacttca acaaacggtg ctgtcccatg  12000

aaccatcagt aaagtcagtg agagagaagg gtgaagctct tttggaactg gtgcaggacg  12060

tcactttaaa ggacaaaata gatcaacttc aaagtgatta ccaggacctg tgcagcatag  12120

gaaaggcaat gatggaagaa attgctggtt ttgaagaccg tttgaacaat cttcaaatga  12180

aaggtgatac tttgattggc caatgtgcag accacctgca agcgaaactt aaacaaaacg  12240

tgcatgctca tctgcagggc acaaaggaca gctactcagc gatctgcagc acagctcaga  12300

ggatgtacca gagtttggaa cacgaacttc agaagcacgt cagccgacaa gacaccctgc  12360

agcagtgcca ggcctggctt tctgcagtcc agccggattt agagccaagt cctcaaccac  12420

ctcttagtag ggcagaagcc attaagcagg tcaaacactt cagagctttg caagagcagg  12480

caaggaccta cctagatctc ctttgctcca tgtgtgacct gtcaaatgct tcggtgaaaa  12540

ccacagcaaa agacattcaa caaacagagc aaacgattga acaaaagctt gtccaggccc  12600

agaacttaac tcagggctgg gaagagatca agcacctgaa gtctgagctc tggatttacc  12660

tgcaagatgc tgatcagcaa ctgcagaaca tgaagaggag gcactctgag ctggagctga  12720

acattgcaca gaacatggtt tcacaagtta aggattttgt taagaaacta cagagcaaac  12780

aggcatccgt gaacaccata atagaaaagg tgaataagtt aacaaagaag gaggaatcgc  12840

ctgaacacaa ggaaataaat catttaaatg atcagtggct cgatttgtgc cgtcagtcta  12900

acaacctgtg cttgcaaagg gaagaggatc ttcagagaac aagagattac catgactgta  12960

tgaatgttgt tgaagtgttc ctagaaaaat ttactacaga atgggataac ttggccagat  13020

ctgatgcaga gagtacagct gtccacctgg aagctttgaa aaagttagca ttggcattgc  13080

aggagagaaa gtatgctatt gaagatctga aagatcaaaa gcagaaaatg atagagcatc  13140

tgaatttaga tgacaaggag ttagtcaaag aacagacgag tcatttagag caacgttggt  13200

ttcagcttga ggacctcatt aaaaggaaaa tccaagtgtc agtcaccaac ttggaggagt  13260

taaatgtggt gcagtccaga tttcaggagc taatggagtg ggcagaagag caacaaccca  13320

acatcgccga ggcccttaag cagagccctc ctccagatat ggctcagaac cttctcatgg  13380

atcacctggc catctgcagt gaactggagg ccaagcagat gctcctgaaa tcgcttataa  13440

aggacgcaga cagggtcatg gcagatcttg gtctcaatga gcgacaggtc atccagaagg  13500

ctctctctga tgcacaaagc cacgtgaatt gtctcagtga cttagtgggc cagcgaagaa  13560

agtacttaaa caaagccttg tccgagaaaa cccagtttct catggcagtg ttccaggcca  13620

ccagccaaat tcagcaacat gagcgaaaga taatgttccg tgaacacatc tgtctgttac  13680

cagatgatgt gagcaaacaa gtcaaaacat gtaagagtgc acaagccagc ctcaagactt  13740

accaaaatga agtcactgga ctttgggccc agggtcgcga actaatgaag gaagtcacag  13800

agcaggaaaa gagtgaagtg ctggggaagc ttcaggaatt gcagagtgtc tatgacagtg  13860

ttttacaaaa gtgcagtcac cggttacaag aactagagaa gaatttggtt tctaggaagc  13920

attttaagga agattttgat aaagcttgcc actggctaaa acaagcagat attgttacat  13980

ttcctgaaat caacctaatg aatgagagtt ctgagcttca tacacaactg gctaaatacc  14040

aaaacattct tgaacaatct ccagaatatg aaaatcttct acttacgctg cagagaactg  14100

ggcagaccat attaccatcg ctgaatgaag tcgatcattc ctacctcagt gaaaagctaa  14160

atgctttgcc tcgacaattt aatgtaattg ttgccttggc taaagacaag ttctataaag  14220

tccaggaagc aattcttgct cggaaggaat atgcttcctt gattgagttg acaacccagt  14280

ctctgagtga acttgaagcc caattcttga ggatgagcaa agttcccacc gacctggccg  14340

ttgaggaggc tctttctctg caagatggtt gcagagccat tctggacgag gtggcgggcc  14400

ttggggaggc ggtggatgaa ctgaaccaga aaaaagaagg ttttcgcagc acaggtcagc  14460

cttggcagcc agacaagatg ctgcaccttg tcaccttata tcacaggctg aagcgacaaa  14520

cagaacagag ggttagctta ttagaagaca ccaccagtgc ttaccaagaa cacgagaaga  14580

tgtgccaaca gctggagaga caactgaagt ctgtaaaaga ggagcagtcc aaagtgaatg  14640

aggaaacgct gcctgcagag gagaagctca aaatgtatca ctccctggca ggaagtctcc  14700

aggactcagg gattgtactg aaacgagtaa ccatacatct tgaagatctt gccccacacc  14760

ttgacccctt ggcttatgag aaagccaggc atcagatcca gtcctggcaa ggggagttaa  14820

aactgttgac ttctgccatt ggtgagacgg tgacagaatg tgagagccga atggtgcaga  14880

gtatagactt ccagactgag atgagtcgct ccctggactg gctgaggaga gtgaaggcag  14940

agctcagtgg gccggtgtac ctagacctca acctgcagga catccaagag gaaatcagaa  15000

aaatccaaat tcatcaggaa gaggtccagt ccagcttgag aatcatgaat gcgctgagtc  15060

acaaggaaaa ggagaagttc acaaaggcca aggagctgat ttctgcggat ttagaacaca  15120

gcctcgctga gctctcagag ctggatggag acatccagga agccttacgc accagacagg  15180

ctaccttgac tgaaatatat agccagtgtc aaaggtatta tcaggtattt caagcagcca  15240

atgactggct tgaggatgcc caagaattgt tacagctggc aggcaatggc ctagacgtgg  15300

agagcgcaga ggaaaatctc aaaagccaca tggaattttt cagtacagag gatcagttcc  15360

atagtaacct ggaggagctc cacagcctgg tagccaccct ggacccactc atcaagccaa  15420

ccggcaaaga agacctagaa cagaaagtgg cttctctgga actcaggagc cagaggatga  15480

gccgggactc tggtgcccaa gtggatctct tgcagagatg cacagctcaa tggcacgatt  15540

accagaaagc aagggaagag gttattgaat tgatgaatga tacagaaaag aaattgtctg  15600

agttttcttt gttgaagact tcgtctagtc atgaagcgga agaaaaattg tcagaacaca  15660

aggctttagt gtcagtggtt aactctttcc atgagaaaat tgtggccctt gaggaaaaag  15720

cttcacaact ggagaaaacc ggaaatgatg ccagcaaagc caccctgagc aggtcaatga  15780

ccaccgtctg gcagcgctgg acacgccttc gagctgtggc ccaggaccag gagaagatcc  15840

tggaagatgc agtggatgag tggacgggct ttaacaacaa ggttaaaaag gccactgaaa  15900

tgattgatca gctgcaagat aagttacctg gaagttcagc agagaaagca tcgaaagcag  15960

agctcttaac tcttcttgaa taccacgaca cgttcgttct ggagctggag cagcagcagt  16020

cggccttggg catgctgcgg cagcaaaccc tgagcatgct ccaggatgga gccgccccaa  16080

cccctgggga agagcctccg ctcatgcagg aaatcaccgc catgcaagat cggtgcctga  16140

acatgcagga gaaagtgaag actaatggaa agttggtgaa gcaagagctg aaggaccgag  16200

aaatggtgga gactcagatc aattctgtga aatgttgggt tcaggaaacg aaagaatatt  16260

tagggaatcc aacaatagaa atagatgctc aacttgaaga acttcagatt ctcctaacag  16320

aagccacaaa tcaccgacag aacattgaaa aaatggcaga agaacagaag gagaagtact  16380

taggtcttta taccatatta ccttctgaac tctcccttca gttggctgaa gtggcgttag  16440

atctaaagat ccgagatcag atccaagaca aaataaaaga agttgagcag agcaaggcca  16500

cgagccagga actcagccgg caaattcaga agttagctaa agacctcaca actattctaa  16560

ctaagctgaa agcgaagaca gataatgtag ttcaagctaa aactgaccaa aaggtgctgg  16620

gagaggaatt agatggctgt aattcaaagt taatggaatt agatgcagca gtacagaaat  16680

tcttggaaca gaatggccaa ctgggtaagc cactggccaa gaagatagga aaactgactg  16740

aacttcacca gcagaccatt agacaagctg agaatcggct ctccaagctc aatcaggcag  16800

catcacattt agaagaatac aatgaaatgc ttgaattaat tttgaagtgg attgaaaaag  16860

ctaaagtctt ggctcatgga actattgcat ggaattctgc aagccagctt cgggaacaat  16920

atattttgca tcagaccctg ctagaagaat ccaaagaaat tgacagtgag ctggaagcaa  16980

tgactgagaa attacagtac ctcactagcg tgtactgtac agaaaaaatg tctcagcaag  17040

tggcagaact gggacgggag actgaggagt tgcgacagat gatcaaaatt cgtttgcaga  17100

acctccaaga tgcagctaag gatatgaaaa aatttgaagc agagttgaaa aagttacaag  17160

ctgccttgga gcaagcccag gcaacactga cttctccaga agttggacgt ctcagtctca  17220

aggagcagct ctctcatcgg cagcatttgt tgtctgagat ggagtcactg aagccgaagg  17280

tgcaagcagt gcagctctgc cagagtgccc tccggatccc cgaggatgtg gttgccagct  17340

tacctctctg tcatgctgct ctgcggctgc aggaagaggc cagccggctg cagcacaccg  17400

ccatccagca gtgtaacatc atgcaggcag ctgtggtaca atatgaacaa tatgagcaag  17460

aaatgaaaca tctccagcaa ctgatagaag gagctcacag agagattgag gataaacctg  17520

ttgccaccag taacatacag gagctgcagg ctcagatttc tcggcatgag gagctggcgc  17580

agaaaattaa gggctaccag gagcagatcg cttctttgaa ttccaagtgc aagatgctga  17640

cgatgaaagc caagcacgcc accatgctgc tgacggtgac cgaggtcgag gggctggcgg  17700

aagggacaga ggacctggat ggggagctcc tccccacgcc ttcggcccac ccctctgtgg  17760

tcatgatgac tgcaggtcgc tgtcacactt tgctgtcacc ggtcactgag gagtctgggg  17820

aggagggaac caacagtgag atttcctctc cacctgcctg tcgctcccct tcacctgtgg  17880

ctaatacaga tgcttctgtt aaccaggaca ttgcatatta ccaagccttg tctgctgaga  17940

ggttgcagac agatgctgca aaaattcacc ccagcacatc cgcatcccag gagttctatg  18000

aaccgggatt ggagccatcc gctactgcca aactgggtga tttgcagcgt tcttgggaaa  18060

ccttaaagaa tgtgatcagt gagaagcagc gcacactcta tgaagctttg gaacgccagc  18120

agaagtacca ggactccctc cagtccatct ctacgaagat ggaggccatt gagctgaaac  18180

tcagtgagag cccagagcct ggcaggagtc cagaaagcca gatggctgaa catcaggcat  18240

tgatggatga gattctcatg ctccaggatg aaatcaatga gctccagtcc tctctcgcag  18300

aggagctggt atccgagtct tgtgaggccg accctgcgga gcagctggcc ttgcagtcca  18360

cgctcactgt cttagccgag cgaatgtcca ccatcaggat gaaagcctcg gggaaacggc  18420

agcttttgga ggagaagttg aatgatcagc tggaggaaca aaggcaggaa caggccctgc  18480

agaggtatcg ctgtgaagcc gatgagctgg acagctggct cttgagtacc aaggccactc  18540

tggacactgc gctgagtcca cccaaggagc ccatggacat ggaggcccag cttatggact  18600

gccagaatat gctggtggaa atagagcaga aggtggtggc tttatcagaa ctgtcagtcc  18660

acaatgagaa cctgctgctg gagggcaaag ctcacaccaa ggacgaggcc gagcagctgg  18720

ctggaaagct gagaaggctc aaggggagcc tgctggagct gcagagagcc ctgcatgata  18780

agcagctcaa catgcaggga acagcacagg agaaggagga gagcgatgtt gacctaacag  18840

ccacgcagag ccccggcgtc caggaatggc tggcccaagc tcgcaccaca tggacccagc  18900

agcggcagag cagtctccag caacaaaaag agttagaaca ggaattagcc gagcagaaga  18960

gtctccttcg ctcagtagcc agtcgtggag aggagattct aattcaacat tcggcggcag  19020

agacctctgg tgatgctggc gaaaaacctg atgtgttatc ccaggagttg gggatggaag  19080

gggagaaatc atccgctgaa gaccagatga gaatgaaatg ggaaagccta catcaagaat  19140

ttagtaccaa gcagaaacta ctacagaatg ttctggaaca ggaacaagag caagtgcttt  19200

atagcaggcc aaatcgactc ttgtctggtg tgccactgta caaaggggac gtgccaaccc  19260

aagataaatc tgcagttaca tctttgctgg atggactgaa ccaagccttc gaggaggttt  19320

catcccagag tggaggggca aagaggcaga gtatacactt ggagcagaag ttgtatgatg  19380

gagtctcagc cacctctact tggttggatg acgttgaaga acgtttattt gttgccacag  19440

cacttttacc agaagaaaca gagacttgtc tcttcaacca agagattctt gccaaagaca  19500

ttaaggaaat gtctgaagaa atggataaga acaaaaactt gttttcccaa gcttttccag  19560

agaatggtga taatcgagat gttattgaag atactttggg ttgtcttttg ggcaggttat  19620

ccttgctaga ctcagtagtg aatcaacgat gtcatcagat gaaagaaaga cttcagcaaa  19680

tactaaattt ccagaatgat ctgaaagtgc tgtttacatc actggctgac aacaaataca  19740

tcattctgca aaaactggca aatgtgtttg aacagcccgt agcagaacaa atagaggcaa  19800

tacaacaggc tgaagatgga ctcaaagaat ttgatgcagg aatcattgaa ttaaagaggc  19860

gtggtgacaa gctacaggtc gagcagccgt ccatgcaaga actctccaag ctccaggaca  19920

tgtatgatga gctgatgatg atcattggct cccggaggag tggtctgaat cagaacctta  19980

cactcaagag tcagtatgag agggccctac aagatctggc tgacctgcta gaaactggtc  20040

aggagaagat ggcaggagac cagaaaatca tcgtgtcttc caaagaggaa atccagcaac  20100

tacttgacaa acataaggaa tactttcagg gcctggaatc tcatatgatc ttgactgaaa  20160

cactcttcag aaagataatc agctttgcag tccaaaagga aacccagttc catacagagc  20220

tgatggctca ggcttctgct gtactgaaac gggctcacaa gaggggtgtg gagctggagt  20280

acattctaga gacgtggtcc catctggatg aggaccagca ggagctcagc agacagctgg  20340

aggtggtgga aagcagcatc ccaagcgtgg gtctggtgga ggagaacgag gacaggctta  20400

ttgaccgcat aacactctac cagcatttaa aatctagcct taatgaatac cagcccaaat  20460

tatatcaagt attagatgat gggaaacgac ttctgatatc catcagctgc tcagatctag  20520

aaagccaact aaatcaactt ggagagtgct ggctaagtaa caccaataaa atgtctaagg  20580

aacttcacag actggaaaca atattgaaac actggaccag atatcaaagt gaatctgcag  20640

atctaattca ctggttacaa tctgcaaaag accggctaga attttggact cagcaatctg  20700

tgacagtccc acaagagctg gaaatggtcc gtgatcatct aaatgctttc ctggagtttt  20760

ctaaagaagt ggatgcccaa tcttccctga aatcatctgt tctgagtact ggaaatcagc  20820

tccttcgact aaaaaaggtg gacacagcca cgctgcgctc tgagctgtcg cgcattgata  20880

gccagtggac tgacctgcta accaatatcc cagccgtcca ggagaagctc caccagctcc  20940

agatggataa actgccttcc cgccatgcca tttctgaagt catgagttgg atttctctaa  21000

tggaaaatgt tattcagaag gatgaagata atattaaaaa ttccataggt tacaaggcaa  21060

ttcatgaata ccttcagaaa tataagggtt ttaagataga cattaactgt aaacagctga  21120

cagtggattt tgtgaaccag tccgtgctac aaatcagcag tcaggatgtg gaaagtaagc  21180

gtagtgataa gactgatttt gctgagcaac ttggagcaat gaataaaagt tggcaaattc  21240

tgcaaggtct agtaactgag aagatccagc tgttggaagg cttattggaa tcttggtcag  21300

aatatgaaaa taatgtacaa tgtctgaaaa catggtttga aacccaggaa aagagactaa  21360

aacaacagca tcgaattgga gatcaggctt ctgttcaaaa tgcactgaaa gactgtcagg  21420

atctggaaga tttgattaaa gcaaaagaaa aagaagtaga gaaaattgag cagaatggac  21480

ttgctttgat tcagaacaag aaagaagacg tctctagcat tgtcatgagc acactgcgag  21540

agctcggcca aacctgggca aatttagatc acatggttgg acaattaaag atactgctga  21600

aatcagtgct tgaccaatgg agtagtcaca aagtggcctt tgacaagata aacagttacc  21660

tcatggaggc cagatactct ctttcccgat tccgtctgct gactggctcc ttagaagctg  21720

tgcaagttca ggtggacaat cttcagaatc tccaagatga tctggaaaaa caggaaagga  21780

gcttacagaa atttggctct atcaccaacc aattattaaa agagtgtcac ccacccgtga  21840

cagaaactct taccaataca ctgaaagaag tcaacatgag atggaataac ttgctggaag  21900

agattgctga gcagctacag tccagcaagg ccctacttca gctttggcaa agatacaagg  21960

actactccaa acagtgtgct tcgacagttc agcagcagga ggatcgaacc aatgagctgt  22020

tgaaggcagc cacaaacaag gacattgccg atgatgaggt tgccacatgg attcaagatt  22080

gcaacgacct cctcaaagga ctgggcacag ttaaagattc cctctttttt ctccatgagc  22140

tgggagagca actgaagcaa caagtggatg cttccgcagc atcagctatt caatcggatc  22200

aactctcttt gagtcaacac ttgtgtgccc tggagcaagc tctctgcaaa cagcagactt  22260

cattacaggc tggagttctt gattatgaaa cctttgccaa gagtttagaa gctttggagg  22320

cctggatagt ggaagctgaa gaaatactac aagggcagga ccctagccac tcatctgacc  22380

tctccacaat ccaggaaagg atggaagaac ttaagggaca gatgttaaaa ttcagcagca  22440

tggctccaga tttagaccgt ctaaatgagc ttggatatag gttacccttg aatgataagg  22500

aaatcaaaag aatgcagaat ctgaaccgcc attggtctct gatctcctct cagactacag  22560

aaagattcag caagttgcag tcatttttgc tacaacatca gactttcttg gaaaaatgtg  22620

aaacatggat ggaattccta gttcagacag aacaaaagtt agcagtagag atttcaggaa  22680

attatcagca ccttttggaa cagcagagag cacacgagtt gtttcaagcc gagatgttca  22740

gtcgtcagca gattttgcac tcaatcatta ttgatgggca acgtcttcta gaacaaggtc  22800

aagttgatga cagggatgaa ttcaacctga aattgacact cctcagtaat caatggcagg  22860

gagtgattcg cagggcccag cagaggcggg ggatcattga cagccagatt cgccagtggc  22920

agcgctatag ggagatggca gaaaagcttc gtaaatggtt ggttgaagtg tcctacctcc  22980

ccatgagtgg tctcggaagt gttcctatac cactgcaaca agcaaggacc ctctttgatg  23040

aagtgcagtt caaagaaaaa gtgtttctgc ggcaacaagg cagctacatc ctgactgtgg  23100

aggctggcaa gcaactcctt ctctcggcgg acagtggcgc tgaggccgcc ttgcaggccg  23160

aactcgctga aatccaagag aaatggaaat cagccagcat gcggctggaa gaacagaaga  23220

aaaaactagc cttcttgttg aaagactggg aaaaatgtga gaaaggaata gcagattccc  23280

tggagaaact acgaactttc aaaaagaagc tttcgcagtc tctcccggat caccatgaag  23340

agctccatgc agaacaaatg cgttgcaagg aattagaaaa tgcagttggg agctggacag  23400

atgacttgac ccagttgagc ctgctgaagg acaccctctc tgcctatatc agtgctgatg  23460

atatctccat tcttaatgaa cgcgtagagc ttctgcaaag gcagtgggaa gaactatgcc  23520

accagctctc cttaaggcgg cagcaaatag gtgaaagatt gaatgaatgg gcagtcttca  23580

gtgaaaagaa caaggaactc tgtgagtggt tgactcaaat ggaaagcaaa gtttctcaga  23640

atggagacat tctcattgaa gaaatgatag agaagctcaa gaaggattat caagaggaaa  23700

ttgctattgc tcaagagaac aaaatacagc tccaacaaat gggagaacga cttgctaaag  23760

ccagccatga aagcaaagca tctgagattg aatacaagct gggaaaggtc aacgaccggt  23820

ggcagcatct cctggacctc attgcagcca gggtgaagaa gctgaaggag accctggtag  23880

ccgtgcagca gcttgataag aacatgagca gcctgaggac ctggctcgct cacatcgagt  23940

cagagctggc caagccaata gtctacgatt cctgtaactc ggaagaaata cagagaaagc  24000

ttaatgagca gcaggagctt cagagagaca tagagaagca cagtacaggt gttgcatctg  24060

tcctcaacct gtgtgaagtc ctgctgcacg actgtgacgc ctgtgccact gatgccgagt  24120

gtgactctat acagcaggct acgagaaacc tggaccggcg gtggagaaac atttgtgcta  24180

tgtccatgga aaggaggctg aaaatcgaag agacgtggcg attgtggcag aaatttctgg  24240

atgactattc acgttttgaa gattggctga agtcttcaga aaggacagct gcttttccca  24300

gctcttctgg ggtgatctat acagttgcca aggaagaact aaagaaattt gaggctttcc  24360

agcgacaggt ccacgagtgc ctgacgcagc tggaactgat caacaagcag taccgccgcc  24420

tggccaggga gaaccgcact gattcagcat gtagcctcaa acagatggtt cacgaaggca  24480

accagagatg ggacaacctg caaaagcgtg tcacctccat cttgcgcaga ctcaagcatt  24540

ttattggcca gcgtgaggag tttgagactg cgcgggacag cattctggtc tggctcacag  24600

agatggatct gcagctcact aatattgaac atttttctga gtgtgatgtt caagctaaaa  24660

taaagcaact caaggccttc cagcaggaaa tttcactgaa ccacaataag attgagcaga  24720

taattgccca aggagaacag ctgatagaaa agagtgagcc cttggatgca gcgatcatcg  24780

aggaggaact agatgagctc cgacggtact gccaggaggt cttcgggcgt gtggaaagat  24840

accataagaa actgatccgc ctgcctctcc cagacgatga gcacgacctc tcagacaggg  24900

agctggagct ggaagactct gcagctctgt cggacctgca ctggcacgac cgctctgcag  24960

acagcctgct ttctccacag ccttcctcca atctctccct ctcgctcgct cagcccctcc  25020

ggagcgagcg gtcaggacga gacaccccgg ctagtgtgga ctccatcccc ctggagtggg  25080

atcacgacta tgacctcagt cgggacctgg agtctgcaat gtccagagct ctgccctctg  25140

aggatgaaga aggtcaggat gacaaagatt tctacctccg gggagctgtt ggcttatcag  25200

atgtaatgat ccccgaaagc cctgaggcct atgtaaaact cacagaaaat gcaatcaaaa  25260

atacctccgg ggaccacagt gccctagagt cacagatccg acaactgggc aaagccctgg  25320

atgatagccg ttttcagata cagcaaaccg aaaatatcat tcgcagcaaa actcccacgg  25380

ggccggagct agacaccagc tacaaaggct acatgaaact gctgggcgaa tgcagtagca  25440

gtatagactc cgtgaagaga ctggagcaca aactgaagga ggaagaggag agccttcctg  25500

gctttgttaa cctgcatagt accgaaaccc aaacggctgg tgtgattgac cgatgggagc  25560

ttctccaggc ccaggcattg agcaaggagt tgaggatgaa gcagaacctc cagaagtggc  25620

agcagtttaa ctcagacttg aacagcatct gggcctggct gggggacacg gaggaggagt  25680

tggaacagct ccagcgtctg gaactcagca ctgacatcca gaccatcgag ctccagatca  25740

aaaagctcaa ggagctccag aaagctgtgg accaccgcaa agccatcatc ctctccatca  25800

atctctgcag ccctgagttc acccaggctg acagcaagga gagccgggac ctgcaggatc  25860

gcttgtcgca gatgaatggg cgctgggacc gagtgtgctc tctgctggag gagtggcggg  25920

gcctgctgca ggatgccctg atgcagtgcc agggtttcca tgaaatgagc catggtttgc  25980

ttcttatgct ggagaacatt gacagaagga aaaatgaaat tgtccctatt gattctaacc  26040

ttgatgcaga gatacttcag gaccatcaca aacagcttat gcaaataaag catgagctgt  26100

tggaatccca actcagagta gcctctttgc aagacatgtc ttgccaacta ctggtgaatg  26160

ctgaaggaac agactgttta gaagccaaag aaaaagtcca tgttattgga aatcggctca  26220

aacttctctt gaaggaggtc agtcgtcata tcaaggaact ggagaagtta ttagacgtgt  26280

caagtagtca gcaggatttg tcttcctggt cttctgctga tgaactggac acctcagggt  26340

ctgtgagtcc cacatcagga aggagcaccc caaacagaca gaaaacgcca cgaggcaagt  26400

gtagtctctc acagcctgga ccctctgtca gcagtccaca tagcaggtcc acaaaaggtg  26460

gctccgattc ctccctttct gagccagggc caggtcggtc cggccgcggc ttcctgttca  26520

gagtcctccg agcagctctt ccccttcagc ttctcctgct cctcctcatc gggcttgcct  26580

gccttgtacc aatgtcagag gaagactaca gctgtgccct ctccaacaac tttgcccggt  26640

cattccaccc catgctcaga tacacgaatg gccctcctcc actctgaact aagcagatgc  26700

catctgcaga agtgctggta gcataaggag gatcgggtca taagcaatcc caaactacca  26760

acaagaggac cttgatcttg gcgaaagccc tcggtgtggc agctttagcc ctcctccaga  26820

tcacatgtgt gcaaattatg gcttcagagg tggaagataa acagtgacgg gggaacaaac  26880

agacaacaag aaggtttgga agaaatctgg tttgagactc tgaaccttag cactaaggag  26940

attgagtaag gacctccaaa gttccccgga ctcatgaatt ctgggccctt ggcccattct  27000

gtgcacagcc aaggacttca gtagaccatc tgggcagctt tcccatggtg ctgctccaac  27060

catcagataa atgaccctcc caagcaccat gtcagtgtcg tacaatctac caaccaacca  27120

gtgctgaaga gattttagaa ccttgtaaca tacaattttt aagagcttat atggcagctt  27180

cctttttacc ttgttttcct ttggggcatg atgttttaac ctttgcttta gaagcacaag  27240

ctgtaaatct aaaaggcact tttttttaga ggtataaaga aaaactagat gtaataaata  27300

agatcatgga aggctttatg tgaaaaaagt tgaatgttat agtaaaaaaa aaaagatatt  27360

tatgtatgta cagtttgcta aagccaagtt ttgtttgtat tgatttcttt gcatttatta  27420

tagatattat aaaata                                                  27436


<210>  387
<211>  8749
<212>  PRT
<213>  Homo sapiens

<400>  387

Met Ala Thr Ser Arg Gly Ala Ser Arg Cys Pro Arg Asp Ile Ala Asn 
1               5                   10                  15


Val Met Gln Arg Leu Gln Asp Glu Gln Glu Ile Val Gln Lys Arg Thr 
            20                  25                  30


Phe Thr Lys Trp Ile Asn Ser His Leu Ala Lys Arg Lys Pro Pro Met 
        35                  40                  45


Val Val Asp Asp Leu Phe Glu Asp Met Lys Asp Gly Val Lys Leu Leu 
    50                  55                  60


Ala Leu Leu Glu Val Leu Ser Gly Gln Lys Leu Pro Cys Glu Gln Gly 
65                  70                  75                  80


Arg Arg Met Lys Arg Ile His Ala Val Ala Asn Ile Gly Thr Ala Leu 
                85                  90                  95


Lys Phe Leu Glu Gly Arg Lys Ser Met His Arg Gly Ser Pro Ile Lys 
            100                 105                 110


Leu Val Asn Ile Asn Ser Thr Asp Ile Ala Asp Gly Arg Pro Ser Ile 
        115                 120                 125


Val Leu Gly Leu Met Trp Thr Ile Ile Leu Tyr Phe Gln Ile Glu Glu 
    130                 135                 140


Leu Thr Ser Asn Leu Pro Gln Leu Gln Ser Leu Ser Ser Ser Ala Ser 
145                 150                 155                 160


Ser Val Asp Ser Ile Val Ser Ser Glu Thr Pro Ser Pro Pro Ser Lys 
                165                 170                 175


Arg Lys Val Thr Thr Lys Ile Gln Gly Asn Ala Lys Lys Ala Leu Leu 
            180                 185                 190


Lys Trp Val Gln Tyr Thr Ala Gly Lys Gln Thr Gly Ile Glu Val Lys 
        195                 200                 205


Asp Phe Gly Lys Ser Trp Arg Ser Gly Val Ala Phe His Ser Val Ile 
    210                 215                 220


His Ala Ile Arg Pro Glu Leu Val Asp Leu Glu Thr Val Lys Gly Arg 
225                 230                 235                 240


Ser Asn Arg Glu Asn Leu Glu Asp Ala Phe Thr Ile Ala Glu Thr Glu 
                245                 250                 255


Leu Gly Ile Pro Arg Leu Leu Asp Pro Glu Asp Val Asp Val Asp Lys 
            260                 265                 270


Pro Asp Glu Lys Ser Ile Met Thr Tyr Val Ala Gln Phe Leu Lys His 
        275                 280                 285


Tyr Pro Asp Ile His Asn Ala Ser Thr Asp Gly Gln Glu Asp Asp Glu 
    290                 295                 300


Ile Leu Pro Gly Phe Pro Ser Phe Ala Asn Ser Val Gln Asn Phe Lys 
305                 310                 315                 320


Arg Glu Asp Arg Val Ile Phe Lys Glu Met Lys Val Trp Ile Glu Gln 
                325                 330                 335


Phe Glu Arg Asp Leu Thr Arg Ala Gln Met Val Glu Ser Asn Leu Gln 
            340                 345                 350


Asp Lys Tyr Gln Ser Phe Lys His Phe Arg Val Gln Tyr Glu Met Lys 
        355                 360                 365


Arg Lys Gln Ile Glu His Leu Ile Gln Pro Leu His Arg Asp Gly Lys 
    370                 375                 380


Leu Ser Leu Asp Gln Ala Leu Val Lys Gln Ser Trp Asp Arg Val Thr 
385                 390                 395                 400


Ser Arg Leu Phe Asp Trp His Ile Gln Leu Asp Lys Ser Leu Pro Ala 
                405                 410                 415


Pro Leu Gly Thr Ile Gly Ala Trp Leu Tyr Arg Ala Glu Val Ala Leu 
            420                 425                 430


Arg Glu Glu Ile Thr Val Gln Gln Val His Glu Glu Thr Ala Asn Thr 
        435                 440                 445


Ile Gln Arg Lys Leu Glu Gln His Lys Asp Leu Leu Gln Asn Thr Asp 
    450                 455                 460


Ala His Lys Arg Ala Phe His Glu Ile Tyr Arg Thr Arg Ser Val Asn 
465                 470                 475                 480


Gly Ile Pro Val Pro Pro Asp Gln Leu Glu Asp Met Ala Glu Arg Phe 
                485                 490                 495


His Phe Val Ser Ser Thr Ser Glu Leu His Leu Met Lys Met Glu Phe 
            500                 505                 510


Leu Glu Leu Lys Tyr Arg Leu Leu Ser Leu Leu Val Leu Ala Glu Ser 
        515                 520                 525


Lys Leu Lys Ser Trp Ile Ile Lys Tyr Gly Arg Arg Glu Ser Val Glu 
    530                 535                 540


Gln Leu Leu Gln Asn Tyr Val Ser Phe Ile Glu Asn Ser Lys Phe Phe 
545                 550                 555                 560


Glu Gln Tyr Glu Val Thr Tyr Gln Ile Leu Lys Gln Thr Ala Glu Met 
                565                 570                 575


Tyr Val Lys Ala Asp Gly Ser Val Glu Glu Ala Glu Asn Val Met Lys 
            580                 585                 590


Phe Met Asn Glu Thr Thr Ala Gln Trp Arg Asn Leu Ser Val Glu Val 
        595                 600                 605


Arg Ser Val Arg Ser Met Leu Glu Glu Val Ile Ser Asn Trp Asp Arg 
    610                 615                 620


Tyr Gly Asn Thr Val Ala Ser Leu Gln Ala Trp Leu Glu Asp Ala Glu 
625                 630                 635                 640


Lys Met Leu Asn Gln Ser Glu Asn Ala Lys Lys Asp Phe Phe Arg Asn 
                645                 650                 655


Leu Pro His Trp Ile Gln Gln His Thr Ala Met Asn Asp Ala Gly Asn 
            660                 665                 670


Phe Leu Ile Glu Thr Cys Asp Glu Met Val Ser Arg Asp Leu Lys Gln 
        675                 680                 685


Gln Leu Leu Leu Leu Asn Gly Arg Trp Arg Glu Leu Phe Met Glu Val 
    690                 695                 700


Lys Gln Tyr Ala Gln Ala Asp Glu Met Asp Arg Met Lys Lys Glu Tyr 
705                 710                 715                 720


Thr Asp Cys Val Val Thr Leu Ser Ala Phe Ala Thr Glu Ala His Lys 
                725                 730                 735


Lys Leu Ser Glu Pro Leu Glu Val Ser Phe Met Asn Val Lys Leu Leu 
            740                 745                 750


Ile Gln Asp Leu Glu Asp Ile Glu Gln Arg Val Pro Val Met Asp Ala 
        755                 760                 765


Gln Tyr Lys Ile Ile Thr Lys Thr Ala His Leu Ile Thr Lys Glu Ser 
    770                 775                 780


Pro Gln Glu Glu Gly Lys Glu Met Phe Ala Thr Met Ser Lys Leu Lys 
785                 790                 795                 800


Glu Gln Leu Thr Lys Val Lys Glu Cys Tyr Ser Pro Leu Leu Tyr Glu 
                805                 810                 815


Ser Gln Gln Leu Leu Ile Pro Leu Glu Glu Leu Glu Lys Gln Met Thr 
            820                 825                 830


Ser Phe Tyr Asp Ser Leu Gly Lys Ile Asn Glu Ile Ile Thr Val Leu 
        835                 840                 845


Glu Arg Glu Ala Gln Ser Ser Ala Leu Phe Lys Gln Lys His Gln Glu 
    850                 855                 860


Leu Leu Ala Cys Gln Glu Asn Cys Lys Lys Thr Leu Thr Leu Ile Glu 
865                 870                 875                 880


Lys Gly Ser Gln Ser Val Gln Lys Phe Val Thr Leu Ser Asn Val Leu 
                885                 890                 895


Lys His Phe Asp Gln Thr Arg Leu Gln Arg Gln Ile Ala Asp Ile His 
            900                 905                 910


Val Ala Phe Gln Ser Met Val Lys Lys Thr Gly Asp Trp Lys Lys His 
        915                 920                 925


Val Glu Thr Asn Ser Arg Leu Met Lys Lys Phe Glu Glu Ser Arg Ala 
    930                 935                 940


Glu Leu Glu Lys Val Leu Arg Ile Ala Gln Glu Gly Leu Glu Glu Lys 
945                 950                 955                 960


Gly Asp Pro Glu Glu Leu Leu Arg Arg His Thr Glu Phe Phe Ser Gln 
                965                 970                 975


Leu Asp Gln Arg Val Leu Asn Ala Phe Leu Lys Ala Cys Asp Glu Leu 
            980                 985                 990


Thr Asp Ile Leu Pro Glu Gln Glu Gln Gln Gly Leu Gln Glu Ala Val 
        995                 1000                1005


Arg Lys Leu His Lys Gln Trp Lys Asp Leu Gln Gly Glu Ala Pro Tyr 
    1010                1015                1020


His Leu Leu His Leu Lys Ile Asp Val Glu Lys Asn Arg Phe Leu Ala 
1025                1030                1035                1040


Ser Val Glu Glu Cys Arg Thr Glu Leu Asp Arg Glu Thr Lys Leu Met 
                1045                1050                1055


Pro Gln Glu Gly Ser Glu Lys Ile Ile Lys Glu His Arg Val Phe Phe 
            1060                1065                1070


Ser Asp Lys Gly Pro His His Leu Cys Glu Lys Arg Leu Gln Leu Ile 
        1075                1080                1085


Glu Glu Leu Cys Val Lys Leu Pro Val Arg Asp Pro Val Arg Asp Thr 
    1090                1095                1100


Pro Gly Thr Cys His Val Thr Leu Lys Glu Leu Arg Ala Ala Ile Asp 
1105                1110                1115                1120


Ser Thr Tyr Arg Lys Leu Met Glu Asp Pro Asp Lys Trp Lys Asp Tyr 
                1125                1130                1135


Thr Ser Arg Phe Ser Glu Phe Ser Ser Trp Ile Ser Thr Asn Glu Thr 
            1140                1145                1150


Gln Leu Lys Gly Ile Lys Gly Glu Ala Ile Asp Thr Ala Asn His Gly 
        1155                1160                1165


Glu Val Lys Arg Ala Val Glu Glu Ile Arg Asn Gly Val Thr Lys Arg 
    1170                1175                1180


Gly Glu Thr Leu Ser Trp Leu Lys Ser Arg Leu Lys Val Leu Thr Glu 
1185                1190                1195                1200


Val Ser Ser Glu Asn Glu Ala Gln Lys Gln Gly Asp Glu Leu Ala Lys 
                1205                1210                1215


Leu Ser Ser Ser Phe Lys Ala Leu Val Thr Leu Leu Ser Glu Val Glu 
            1220                1225                1230


Lys Met Leu Ser Asn Phe Gly Asp Cys Val Gln Tyr Lys Glu Ile Val 
        1235                1240                1245


Lys Asn Ser Leu Glu Glu Leu Ile Ser Gly Ser Lys Glu Val Gln Glu 
    1250                1255                1260


Gln Ala Glu Lys Ile Leu Asp Thr Glu Asn Leu Phe Glu Ala Gln Gln 
1265                1270                1275                1280


Leu Leu Leu His His Gln Gln Lys Thr Lys Arg Ile Ser Ala Lys Lys 
                1285                1290                1295


Arg Asp Val Gln Gln Gln Ile Ala Gln Ala Gln Gln Gly Glu Gly Gly 
            1300                1305                1310


Leu Pro Asp Arg Gly His Glu Glu Leu Arg Lys Leu Glu Ser Thr Leu 
        1315                1320                1325


Asp Gly Leu Glu Arg Ser Arg Glu Arg Gln Glu Arg Arg Ile Gln Val 
    1330                1335                1340


Thr Leu Arg Lys Trp Glu Arg Phe Glu Thr Asn Lys Glu Thr Val Val 
1345                1350                1355                1360


Arg Tyr Leu Phe Gln Thr Gly Ser Ser His Glu Arg Phe Leu Ser Phe 
                1365                1370                1375


Ser Ser Leu Glu Ser Leu Ser Ser Glu Leu Glu Gln Thr Lys Glu Phe 
            1380                1385                1390


Ser Lys Arg Thr Glu Ser Ile Ala Val Gln Ala Glu Asn Leu Val Lys 
        1395                1400                1405


Glu Ala Ser Glu Ile Pro Leu Gly Pro Gln Asn Lys Gln Leu Leu Gln 
    1410                1415                1420


Gln Gln Ala Lys Ser Ile Lys Glu Gln Val Lys Lys Leu Glu Asp Thr 
1425                1430                1435                1440


Leu Glu Glu Asp Ile Lys Thr Met Glu Met Val Lys Thr Lys Trp Asp 
                1445                1450                1455


His Phe Gly Ser Asn Phe Glu Thr Leu Ser Val Trp Ile Thr Glu Lys 
            1460                1465                1470


Glu Lys Glu Leu Asn Ala Leu Glu Thr Ser Ser Ser Ala Met Asp Met 
        1475                1480                1485


Gln Ile Ser Gln Ile Lys Val Thr Ile Gln Glu Ile Glu Ser Lys Leu 
    1490                1495                1500


Ser Ser Ile Val Gly Leu Glu Glu Glu Ala Gln Ser Phe Ala Gln Phe 
1505                1510                1515                1520


Val Thr Thr Gly Glu Ser Ala Arg Ile Lys Ala Lys Leu Thr Gln Ile 
                1525                1530                1535


Arg Arg Tyr Gly Glu Glu Leu Arg Glu His Ala Gln Cys Leu Glu Gly 
            1540                1545                1550


Thr Ile Leu Gly His Leu Ser Gln Gln Gln Lys Phe Glu Glu Asn Leu 
        1555                1560                1565


Arg Lys Ile Gln Gln Ser Val Ser Glu Phe Glu Asp Lys Leu Ala Val 
    1570                1575                1580


Pro Ile Lys Ile Cys Ser Ser Ala Thr Glu Thr Tyr Lys Val Leu Gln 
1585                1590                1595                1600


Glu His Met Asp Leu Cys Gln Ala Leu Glu Ser Leu Ser Ser Ala Ile 
                1605                1610                1615


Thr Ala Phe Ser Ala Ser Ala Arg Lys Val Val Asn Arg Asp Ser Cys 
            1620                1625                1630


Val Gln Glu Ala Ala Ala Leu Gln Gln Gln Tyr Glu Asp Ile Leu Arg 
        1635                1640                1645


Arg Ala Lys Glu Arg Gln Thr Ala Leu Glu Asn Leu Leu Ala His Trp 
    1650                1655                1660


Gln Arg Leu Glu Lys Glu Leu Ser Ser Phe Leu Thr Trp Leu Glu Arg 
1665                1670                1675                1680


Gly Glu Ala Lys Ala Ser Ser Pro Glu Met Asp Ile Ser Ala Asp Arg 
                1685                1690                1695


Val Lys Val Glu Gly Glu Leu Gln Leu Ile Gln Ala Leu Gln Asn Glu 
            1700                1705                1710


Val Val Ser Gln Ala Ser Phe Tyr Ser Lys Leu Leu Gln Leu Lys Glu 
        1715                1720                1725


Ser Leu Phe Ser Val Ala Ser Lys Asp Asp Val Lys Met Met Lys Leu 
    1730                1735                1740


His Leu Glu Gln Leu Asp Glu Arg Trp Arg Asp Leu Pro Gln Ile Ile 
1745                1750                1755                1760


Asn Lys Arg Ile Asn Phe Leu Gln Ser Val Val Ala Glu His Gln Gln 
                1765                1770                1775


Phe Asp Glu Leu Leu Leu Ser Phe Ser Val Trp Ile Lys Leu Phe Leu 
            1780                1785                1790


Ser Glu Leu Gln Thr Thr Ser Glu Ile Ser Ile Met Asp His Gln Val 
        1795                1800                1805


Ala Leu Thr Arg His Lys Asp His Ala Ala Glu Val Glu Ser Lys Lys 
    1810                1815                1820


Gly Glu Leu Gln Ser Leu Gln Gly His Leu Ala Lys Leu Gly Ser Leu 
1825                1830                1835                1840


Gly Arg Ala Glu Asp Leu His Leu Leu Gln Gly Lys Ala Glu Asp Cys 
                1845                1850                1855


Phe Gln Leu Phe Glu Glu Ala Ser Gln Val Val Glu Arg Arg Gln Leu 
            1860                1865                1870


Ala Leu Ser His Leu Ala Glu Phe Leu Gln Ser His Ala Ser Leu Ser 
        1875                1880                1885


Gly Ile Leu Arg Gln Leu Arg Gln Thr Val Glu Ala Thr Asn Ser Met 
    1890                1895                1900


Asn Lys Asn Glu Ser Asp Leu Ile Glu Lys Asp Leu Asn Asp Ala Leu 
1905                1910                1915                1920


Gln Asn Ala Lys Ala Leu Glu Ser Ala Ala Val Ser Leu Asp Gly Ile 
                1925                1930                1935


Leu Ser Lys Ala Gln Tyr His Leu Lys Ile Gly Ser Ser Glu Gln Arg 
            1940                1945                1950


Thr Ser Cys Arg Ala Thr Ala Asp Gln Leu Cys Gly Glu Val Glu Arg 
        1955                1960                1965


Ile Gln Asn Leu Leu Gly Thr Lys Gln Ser Glu Ala Asp Ala Leu Ala 
    1970                1975                1980


Val Leu Lys Lys Ala Phe Gln Asp Gln Lys Glu Glu Leu Leu Lys Ser 
1985                1990                1995                2000


Ile Glu Asp Ile Glu Glu Arg Thr Asp Lys Glu Arg Leu Lys Glu Pro 
                2005                2010                2015


Thr Arg Gln Ala Leu Gln Gln Arg Leu Arg Val Phe Asn Gln Leu Glu 
            2020                2025                2030


Asp Glu Leu Asn Ser His Glu His Glu Leu Cys Trp Leu Lys Asp Lys 
        2035                2040                2045


Ala Lys Gln Ile Ala Gln Lys Asp Val Ala Phe Ala Pro Glu Val Asp 
    2050                2055                2060


Arg Glu Ile Asn Arg Leu Glu Val Thr Trp Asp Asp Thr Lys Arg Leu 
2065                2070                2075                2080


Ile His Glu Asn Gln Gly Gln Cys Cys Gly Leu Ile Asp Leu Met Arg 
                2085                2090                2095


Glu Tyr Gln Asn Leu Lys Ser Ala Val Ser Lys Val Leu Glu Asn Ala 
            2100                2105                2110


Ser Ser Val Ile Val Thr Arg Thr Thr Ile Lys Asp Gln Glu Asp Leu 
        2115                2120                2125


Lys Trp Ala Phe Ser Lys His Glu Thr Ala Lys Asn Lys Met Asn Tyr 
    2130                2135                2140


Lys Gln Lys Asp Leu Asp Asn Phe Thr Ser Lys Gly Lys His Leu Leu 
2145                2150                2155                2160


Ser Glu Leu Lys Lys Ile His Ser Ser Asp Phe Ser Leu Val Lys Thr 
                2165                2170                2175


Asp Met Glu Ser Thr Val Asp Lys Trp Leu Asp Val Ser Glu Lys Leu 
            2180                2185                2190


Glu Glu Asn Met Asp Arg Leu Arg Val Ser Leu Ser Ile Trp Asp Asp 
        2195                2200                2205


Val Leu Ser Thr Arg Asp Glu Ile Glu Gly Trp Ser Asn Asn Cys Val 
    2210                2215                2220


Pro Gln Met Ala Glu Asn Ile Ser Asn Leu Asp Asn His Leu Arg Ala 
2225                2230                2235                2240


Glu Glu Leu Leu Lys Glu Phe Glu Ser Glu Val Lys Asn Lys Ala Leu 
                2245                2250                2255


Arg Leu Glu Glu Leu His Ser Lys Val Asn Asp Leu Lys Glu Leu Thr 
            2260                2265                2270


Lys Asn Leu Glu Thr Pro Pro Asp Leu Gln Phe Ile Glu Ala Asp Leu 
        2275                2280                2285


Met Gln Lys Leu Glu His Ala Lys Glu Ile Thr Glu Val Ala Lys Gly 
    2290                2295                2300


Thr Leu Lys Asp Phe Thr Ala Gln Ser Thr Gln Val Glu Lys Phe Ile 
2305                2310                2315                2320


Asn Asp Ile Thr Thr Trp Phe Thr Lys Val Glu Glu Ser Leu Met Asn 
                2325                2330                2335


Cys Ala Gln Asn Glu Thr Cys Glu Ala Leu Lys Lys Val Lys Asp Ile 
            2340                2345                2350


Gln Lys Glu Leu Gln Ser Gln Gln Ser Asn Ile Ser Ser Thr Gln Glu 
        2355                2360                2365


Asn Leu Asn Ser Leu Cys Arg Lys Tyr His Ser Ala Glu Leu Glu Ser 
    2370                2375                2380


Leu Gly Arg Ala Met Thr Gly Leu Ile Lys Lys His Glu Ala Val Ser 
2385                2390                2395                2400


Gln Leu Cys Ser Lys Thr Gln Ala Ser Leu Gln Glu Ser Leu Glu Lys 
                2405                2410                2415


His Phe Ser Glu Ser Met Gln Glu Phe Gln Glu Trp Phe Leu Gly Ala 
            2420                2425                2430


Lys Ala Ala Ala Lys Glu Ser Ser Asp Arg Thr Gly Asp Ser Lys Val 
        2435                2440                2445


Leu Glu Ala Lys Leu His Asp Leu Gln Asn Ile Leu Asp Ser Val Ser 
    2450                2455                2460


Asp Gly Gln Ser Lys Leu Asp Ala Val Thr Gln Glu Gly Gln Thr Leu 
2465                2470                2475                2480


Tyr Ala His Leu Ser Lys Gln Ile Val Ser Ser Ile Gln Glu Gln Ile 
                2485                2490                2495


Thr Lys Ala Asn Glu Glu Phe Gln Ala Phe Leu Lys Gln Cys Leu Lys 
            2500                2505                2510


Asp Lys Gln Ala Leu Gln Asp Cys Ala Ser Glu Leu Gly Ser Phe Glu 
        2515                2520                2525


Asp Gln His Arg Lys Leu Asn Leu Trp Ile His Glu Met Glu Glu Arg 
    2530                2535                2540


Phe Asn Thr Glu Asn Leu Gly Glu Ser Lys Gln His Ile Pro Glu Lys 
2545                2550                2555                2560


Lys Asn Glu Val His Lys Val Glu Met Phe Leu Gly Glu Leu Leu Ala 
                2565                2570                2575


Ala Arg Glu Ser Leu Asp Lys Leu Ser Gln Arg Gly Gln Leu Leu Ser 
            2580                2585                2590


Glu Glu Gly His Gly Ala Gly Gln Glu Gly Arg Leu Cys Ser Gln Leu 
        2595                2600                2605


Leu Thr Ser His Gln Asn Leu Leu Arg Met Thr Lys Glu Lys Leu Arg 
    2610                2615                2620


Ser Cys Gln Val Ala Leu Gln Glu His Glu Ala Leu Glu Glu Ala Leu 
2625                2630                2635                2640


Gln Ser Met Trp Phe Trp Val Lys Ala Ile Gln Asp Arg Leu Ala Cys 
                2645                2650                2655


Ala Glu Ser Thr Leu Gly Ser Lys Asp Thr Leu Glu Lys Arg Leu Ser 
            2660                2665                2670


Gln Ile Gln Asp Ile Leu Leu Met Lys Gly Glu Gly Glu Val Lys Leu 
        2675                2680                2685


Asn Met Ala Ile Gly Lys Gly Glu Gln Ala Leu Arg Ser Ser Asn Lys 
    2690                2695                2700


Glu Gly Gln Arg Val Ile Gln Thr Gln Leu Glu Thr Leu Lys Glu Val 
2705                2710                2715                2720


Trp Ala Asp Ile Met Ser Ser Ser Val His Ala Gln Ser Thr Leu Glu 
                2725                2730                2735


Ser Val Ile Ser Gln Trp Asn Asp Tyr Val Glu Arg Lys Asn Gln Leu 
            2740                2745                2750


Glu Gln Trp Met Glu Ser Val Asp Gln Lys Ile Glu His Pro Leu Gln 
        2755                2760                2765


Pro Gln Pro Gly Leu Lys Glu Lys Phe Val Leu Leu Asp His Leu Gln 
    2770                2775                2780


Ser Ile Leu Ser Glu Ala Glu Asp His Thr Arg Ala Leu His Arg Leu 
2785                2790                2795                2800


Ile Ala Lys Ser Arg Glu Leu Tyr Glu Lys Thr Glu Asp Glu Ser Phe 
                2805                2810                2815


Lys Asp Thr Ala Gln Glu Glu Leu Lys Thr Gln Phe Asn Asp Ile Met 
            2820                2825                2830


Thr Val Ala Lys Glu Lys Met Arg Lys Val Glu Glu Ile Val Lys Asp 
        2835                2840                2845


His Leu Met Tyr Leu Asp Ala Val His Glu Phe Thr Asp Trp Leu His 
    2850                2855                2860


Ser Ala Lys Glu Glu Leu His Arg Trp Ser Asp Met Ser Gly Asp Ser 
2865                2870                2875                2880


Ser Ala Thr Gln Lys Lys Leu Ser Lys Ile Lys Glu Leu Ile Asp Ser 
                2885                2890                2895


Arg Glu Ile Gly Ala Ser Arg Leu Ser Arg Val Glu Ser Leu Ala Pro 
            2900                2905                2910


Glu Val Lys Gln Asn Thr Thr Ala Ser Gly Cys Glu Leu Met His Thr 
        2915                2920                2925


Glu Met Gln Ala Leu Arg Ala Asp Trp Lys Gln Trp Glu Asp Ser Val 
    2930                2935                2940


Phe Gln Thr Gln Ser Cys Leu Glu Asn Leu Val Ser Gln Met Ala Leu 
2945                2950                2955                2960


Ser Glu Gln Glu Phe Ser Gly Gln Val Ala Gln Leu Glu Gln Ala Leu 
                2965                2970                2975


Glu Gln Phe Ser Ala Leu Leu Lys Thr Trp Ala Gln Gln Leu Thr Leu 
            2980                2985                2990


Leu Glu Gly Lys Asn Thr Asp Glu Glu Ile Val Glu Cys Trp His Lys 
        2995                3000                3005


Gly Gln Glu Ile Leu Asp Ala Leu Gln Lys Ala Glu Pro Arg Thr Glu 
    3010                3015                3020


Asp Leu Lys Ser Gln Leu Asn Glu Leu Cys Arg Phe Ser Arg Asp Leu 
3025                3030                3035                3040


Ser Thr Tyr Ser Gly Lys Val Ser Gly Leu Ile Lys Glu Tyr Asn Cys 
                3045                3050                3055


Leu Cys Leu Gln Ala Ser Lys Gly Cys Gln Asn Lys Glu Gln Ile Leu 
            3060                3065                3070


Gln Gln Arg Phe Arg Lys Ala Phe Arg Asp Phe Gln Gln Trp Leu Val 
        3075                3080                3085


Asn Ala Lys Ile Thr Thr Ala Lys Cys Phe Asp Ile Pro Gln Asn Ile 
    3090                3095                3100


Ser Glu Val Ser Thr Ser Leu Gln Lys Ile Gln Glu Phe Leu Ser Glu 
3105                3110                3115                3120


Ser Glu Asn Gly Gln His Lys Leu Asn Met Met Leu Ser Lys Gly Glu 
                3125                3130                3135


Leu Leu Ser Thr Leu Leu Thr Lys Glu Lys Ala Lys Gly Ile Gln Ala 
            3140                3145                3150


Lys Val Thr Ala Ala Lys Glu Asp Trp Lys Asn Phe His Ser Asn Leu 
        3155                3160                3165


His Gln Lys Glu Ser Ala Leu Glu Asn Leu Lys Ile Gln Met Lys Asp 
    3170                3175                3180


Phe Glu Val Ser Ala Glu Pro Ile Gln Asp Trp Leu Ser Lys Thr Glu 
3185                3190                3195                3200


Lys Met Val His Glu Ser Ser Asn Arg Leu Tyr Asp Leu Pro Ala Lys 
                3205                3210                3215


Arg Arg Glu Gln Gln Lys Leu Gln Ser Val Leu Glu Glu Ile His Cys 
            3220                3225                3230


Tyr Glu Pro Gln Leu Asn Arg Leu Lys Glu Lys Ala Gln Gln Leu Trp 
        3235                3240                3245


Glu Gly Gln Ala Ala Ser Lys Ser Phe Arg His Arg Val Ser Gln Leu 
    3250                3255                3260


Ser Ser Gln Tyr Leu Ala Leu Ser Asn Leu Thr Lys Glu Lys Val Ser 
3265                3270                3275                3280


Arg Leu Asp Arg Ile Val Ala Glu His Asn Gln Phe Ser Leu Gly Ile 
                3285                3290                3295


Lys Glu Leu Gln Asp Trp Met Thr Asp Ala Ile His Met Leu Asp Ser 
            3300                3305                3310


Tyr Cys His Pro Thr Ser Asp Lys Ser Val Leu Asp Ser Arg Thr Leu 
        3315                3320                3325


Lys Leu Glu Ala Leu Leu Ser Val Lys Gln Glu Lys Glu Ile Gln Met 
    3330                3335                3340


Lys Met Ile Val Thr Arg Gly Glu Ser Val Leu Gln Asn Thr Ser Pro 
3345                3350                3355                3360


Glu Gly Ile Pro Thr Ile Gln Gln Gln Leu Gln Ser Val Lys Asp Met 
                3365                3370                3375


Trp Ala Ser Leu Leu Ser Ala Gly Ile Arg Cys Lys Ser Gln Leu Glu 
            3380                3385                3390


Gly Ala Leu Ser Lys Trp Thr Ser Tyr Gln Asp Gly Val Arg Gln Phe 
        3395                3400                3405


Ser Gly Trp Met Asp Ser Met Glu Ala Asn Leu Asn Glu Ser Glu Arg 
    3410                3415                3420


Gln His Ala Glu Leu Arg Asp Lys Thr Thr Met Leu Gly Lys Ala Lys 
3425                3430                3435                3440


Leu Leu Asn Glu Glu Val Leu Ser Tyr Ser Ser Leu Leu Glu Thr Ile 
                3445                3450                3455


Glu Val Lys Gly Ala Gly Met Thr Glu His Tyr Val Thr Gln Leu Glu 
            3460                3465                3470


Leu Gln Asp Leu Gln Glu Arg Tyr Arg Ala Ile Gln Glu Arg Ala Lys 
        3475                3480                3485


Glu Ala Val Thr Lys Ser Glu Lys Leu Val Arg Leu His Gln Glu Tyr 
    3490                3495                3500


Gln Arg Asp Leu Lys Ala Phe Glu Val Trp Leu Gly Gln Glu Gln Glu 
3505                3510                3515                3520


Lys Leu Asp Gln Tyr Ser Val Leu Glu Gly Asp Ala His Thr His Glu 
                3525                3530                3535


Thr Thr Leu Arg Asp Leu Gln Glu Leu Gln Val His Cys Ala Glu Gly 
            3540                3545                3550


Gln Ala Leu Leu Asn Ser Val Leu His Thr Arg Glu Asp Val Ile Pro 
        3555                3560                3565


Ser Gly Ile Pro Gln Ala Glu Asp Arg Ala Leu Glu Ser Leu Arg Gln 
    3570                3575                3580


Asp Trp Gln Ala Tyr Gln His Arg Leu Ser Glu Thr Arg Thr Gln Phe 
3585                3590                3595                3600


Asn Asn Val Val Asn Lys Leu Arg Leu Met Glu Gln Lys Phe Gln Gln 
                3605                3610                3615


Val Asp Glu Trp Leu Lys Thr Ala Glu Glu Lys Lys Trp His Glu Glu 
            3620                3625                3630


Val Thr Ala Tyr Arg Asp Glu Val Glu Glu Val Gly Ala Arg Ala Gln 
        3635                3640                3645


Glu Ile Leu Asp Glu Ser His Val Asn Ser Arg Met Gly Cys Gln Ala 
    3650                3655                3660


Thr Gln Leu Thr Ser Arg Tyr Gln Ala Leu Leu Leu Gln Val Leu Glu 
3665                3670                3675                3680


Gln Ile Lys Phe Leu Glu Glu Glu Ile Gln Ser Leu Glu Glu Ser Glu 
                3685                3690                3695


Ser Ser Leu Ser Ser Tyr Ser Asp Trp Tyr Gly Ser Thr His Lys Asn 
            3700                3705                3710


Phe Lys Asn Val Ala Thr Lys Ile Asp Lys Val Asp Thr Val Met Met 
        3715                3720                3725


Gly Lys Lys Leu Lys Thr Leu Glu Val Leu Leu Lys Asp Met Glu Lys 
    3730                3735                3740


Gly His Ser Leu Leu Lys Ser Ala Arg Glu Lys Gly Glu Arg Ala Val 
3745                3750                3755                3760


Lys Tyr Leu Glu Glu Gly Glu Ala Glu Arg Leu Arg Lys Glu Ile His 
                3765                3770                3775


Asp His Met Glu Gln Leu Lys Glu Leu Thr Ser Thr Val Arg Lys Glu 
            3780                3785                3790


His Met Thr Leu Glu Lys Gly Leu His Leu Ala Lys Glu Phe Ser Asp 
        3795                3800                3805


Lys Cys Lys Ala Leu Thr Gln Trp Ile Ala Glu Tyr Gln Glu Ile Leu 
    3810                3815                3820


His Val Pro Glu Glu Pro Lys Met Glu Leu Tyr Glu Lys Lys Ala Gln 
3825                3830                3835                3840


Leu Ser Lys Tyr Lys Ser Leu Gln Gln Thr Val Leu Ser His Glu Pro 
                3845                3850                3855


Ser Val Lys Ser Val Arg Glu Lys Gly Glu Ala Leu Leu Glu Leu Val 
            3860                3865                3870


Gln Asp Val Thr Leu Lys Asp Lys Ile Asp Gln Leu Gln Ser Asp Tyr 
        3875                3880                3885


Gln Asp Leu Cys Ser Ile Gly Lys Ala Met Met Glu Glu Ile Ala Gly 
    3890                3895                3900


Phe Glu Asp Arg Leu Asn Asn Leu Gln Met Lys Gly Asp Thr Leu Ile 
3905                3910                3915                3920


Gly Gln Cys Ala Asp His Leu Gln Ala Lys Leu Lys Gln Asn Val His 
                3925                3930                3935


Ala His Leu Gln Gly Thr Lys Asp Ser Tyr Ser Ala Ile Cys Ser Thr 
            3940                3945                3950


Ala Gln Arg Met Tyr Gln Ser Leu Glu His Glu Leu Gln Lys His Val 
        3955                3960                3965


Ser Arg Gln Asp Thr Leu Gln Gln Cys Gln Ala Trp Leu Ser Ala Val 
    3970                3975                3980


Gln Pro Asp Leu Glu Pro Ser Pro Gln Pro Pro Leu Ser Arg Ala Glu 
3985                3990                3995                4000


Ala Ile Lys Gln Val Lys His Phe Arg Ala Leu Gln Glu Gln Ala Arg 
                4005                4010                4015


Thr Tyr Leu Asp Leu Leu Cys Ser Met Cys Asp Leu Ser Asn Ala Ser 
            4020                4025                4030


Val Lys Thr Thr Ala Lys Asp Ile Gln Gln Thr Glu Gln Thr Ile Glu 
        4035                4040                4045


Gln Lys Leu Val Gln Ala Gln Asn Leu Thr Gln Gly Trp Glu Glu Ile 
    4050                4055                4060


Lys His Leu Lys Ser Glu Leu Trp Ile Tyr Leu Gln Asp Ala Asp Gln 
4065                4070                4075                4080


Gln Leu Gln Asn Met Lys Arg Arg His Ser Glu Leu Glu Leu Asn Ile 
                4085                4090                4095


Ala Gln Asn Met Val Ser Gln Val Lys Asp Phe Val Lys Lys Leu Gln 
            4100                4105                4110


Ser Lys Gln Ala Ser Val Asn Thr Ile Ile Glu Lys Val Asn Lys Leu 
        4115                4120                4125


Thr Lys Lys Glu Glu Ser Pro Glu His Lys Glu Ile Asn His Leu Asn 
    4130                4135                4140


Asp Gln Trp Leu Asp Leu Cys Arg Gln Ser Asn Asn Leu Cys Leu Gln 
4145                4150                4155                4160


Arg Glu Glu Asp Leu Gln Arg Thr Arg Asp Tyr His Asp Cys Met Asn 
                4165                4170                4175


Val Val Glu Val Phe Leu Glu Lys Phe Thr Thr Glu Trp Asp Asn Leu 
            4180                4185                4190


Ala Arg Ser Asp Ala Glu Ser Thr Ala Val His Leu Glu Ala Leu Lys 
        4195                4200                4205


Lys Leu Ala Leu Ala Leu Gln Glu Arg Lys Tyr Ala Ile Glu Asp Leu 
    4210                4215                4220


Lys Asp Gln Lys Gln Lys Met Ile Glu His Leu Asn Leu Asp Asp Lys 
4225                4230                4235                4240


Glu Leu Val Lys Glu Gln Thr Ser His Leu Glu Gln Arg Trp Phe Gln 
                4245                4250                4255


Leu Glu Asp Leu Ile Lys Arg Lys Ile Gln Val Ser Val Thr Asn Leu 
            4260                4265                4270


Glu Glu Leu Asn Val Val Gln Ser Arg Phe Gln Glu Leu Met Glu Trp 
        4275                4280                4285


Ala Glu Glu Gln Gln Pro Asn Ile Ala Glu Ala Leu Lys Gln Ser Pro 
    4290                4295                4300


Pro Pro Asp Met Ala Gln Asn Leu Leu Met Asp His Leu Ala Ile Cys 
4305                4310                4315                4320


Ser Glu Leu Glu Ala Lys Gln Met Leu Leu Lys Ser Leu Ile Lys Asp 
                4325                4330                4335


Ala Asp Arg Val Met Ala Asp Leu Gly Leu Asn Glu Arg Gln Val Ile 
            4340                4345                4350


Gln Lys Ala Leu Ser Asp Ala Gln Ser His Val Asn Cys Leu Ser Asp 
        4355                4360                4365


Leu Val Gly Gln Arg Arg Lys Tyr Leu Asn Lys Ala Leu Ser Glu Lys 
    4370                4375                4380


Thr Gln Phe Leu Met Ala Val Phe Gln Ala Thr Ser Gln Ile Gln Gln 
4385                4390                4395                4400


His Glu Arg Lys Ile Met Phe Arg Glu His Ile Cys Leu Leu Pro Asp 
                4405                4410                4415


Asp Val Ser Lys Gln Val Lys Thr Cys Lys Ser Ala Gln Ala Ser Leu 
            4420                4425                4430


Lys Thr Tyr Gln Asn Glu Val Thr Gly Leu Trp Ala Gln Gly Arg Glu 
        4435                4440                4445


Leu Met Lys Glu Val Thr Glu Gln Glu Lys Ser Glu Val Leu Gly Lys 
    4450                4455                4460


Leu Gln Glu Leu Gln Ser Val Tyr Asp Ser Val Leu Gln Lys Cys Ser 
4465                4470                4475                4480


His Arg Leu Gln Glu Leu Glu Lys Asn Leu Val Ser Arg Lys His Phe 
                4485                4490                4495


Lys Glu Asp Phe Asp Lys Ala Cys His Trp Leu Lys Gln Ala Asp Ile 
            4500                4505                4510


Val Thr Phe Pro Glu Ile Asn Leu Met Asn Glu Ser Ser Glu Leu His 
        4515                4520                4525


Thr Gln Leu Ala Lys Tyr Gln Asn Ile Leu Glu Gln Ser Pro Glu Tyr 
    4530                4535                4540


Glu Asn Leu Leu Leu Thr Leu Gln Arg Thr Gly Gln Thr Ile Leu Pro 
4545                4550                4555                4560


Ser Leu Asn Glu Val Asp His Ser Tyr Leu Ser Glu Lys Leu Asn Ala 
                4565                4570                4575


Leu Pro Arg Gln Phe Asn Val Ile Val Ala Leu Ala Lys Asp Lys Phe 
            4580                4585                4590


Tyr Lys Val Gln Glu Ala Ile Leu Ala Arg Lys Glu Tyr Ala Ser Leu 
        4595                4600                4605


Ile Glu Leu Thr Thr Gln Ser Leu Ser Glu Leu Glu Ala Gln Phe Leu 
    4610                4615                4620


Arg Met Ser Lys Val Pro Thr Asp Leu Ala Val Glu Glu Ala Leu Ser 
4625                4630                4635                4640


Leu Gln Asp Gly Cys Arg Ala Ile Leu Asp Glu Val Ala Gly Leu Gly 
                4645                4650                4655


Glu Ala Val Asp Glu Leu Asn Gln Lys Lys Glu Gly Phe Arg Ser Thr 
            4660                4665                4670


Gly Gln Pro Trp Gln Pro Asp Lys Met Leu His Leu Val Thr Leu Tyr 
        4675                4680                4685


His Arg Leu Lys Arg Gln Thr Glu Gln Arg Val Ser Leu Leu Glu Asp 
    4690                4695                4700


Thr Thr Ser Ala Tyr Gln Glu His Glu Lys Met Cys Gln Gln Leu Glu 
4705                4710                4715                4720


Arg Gln Leu Lys Ser Val Lys Glu Glu Gln Ser Lys Val Asn Glu Glu 
                4725                4730                4735


Thr Leu Pro Ala Glu Glu Lys Leu Lys Met Tyr His Ser Leu Ala Gly 
            4740                4745                4750


Ser Leu Gln Asp Ser Gly Ile Val Leu Lys Arg Val Thr Ile His Leu 
        4755                4760                4765


Glu Asp Leu Ala Pro His Leu Asp Pro Leu Ala Tyr Glu Lys Ala Arg 
    4770                4775                4780


His Gln Ile Gln Ser Trp Gln Gly Glu Leu Lys Leu Leu Thr Ser Ala 
4785                4790                4795                4800


Ile Gly Glu Thr Val Thr Glu Cys Glu Ser Arg Met Val Gln Ser Ile 
                4805                4810                4815


Asp Phe Gln Thr Glu Met Ser Arg Ser Leu Asp Trp Leu Arg Arg Val 
            4820                4825                4830


Lys Ala Glu Leu Ser Gly Pro Val Tyr Leu Asp Leu Asn Leu Gln Asp 
        4835                4840                4845


Ile Gln Glu Glu Ile Arg Lys Ile Gln Ile His Gln Glu Glu Val Gln 
    4850                4855                4860


Ser Ser Leu Arg Ile Met Asn Ala Leu Ser His Lys Glu Lys Glu Lys 
4865                4870                4875                4880


Phe Thr Lys Ala Lys Glu Leu Ile Ser Ala Asp Leu Glu His Ser Leu 
                4885                4890                4895


Ala Glu Leu Ser Glu Leu Asp Gly Asp Ile Gln Glu Ala Leu Arg Thr 
            4900                4905                4910


Arg Gln Ala Thr Leu Thr Glu Ile Tyr Ser Gln Cys Gln Arg Tyr Tyr 
        4915                4920                4925


Gln Val Phe Gln Ala Ala Asn Asp Trp Leu Glu Asp Ala Gln Glu Leu 
    4930                4935                4940


Leu Gln Leu Ala Gly Asn Gly Leu Asp Val Glu Ser Ala Glu Glu Asn 
4945                4950                4955                4960


Leu Lys Ser His Met Glu Phe Phe Ser Thr Glu Asp Gln Phe His Ser 
                4965                4970                4975


Asn Leu Glu Glu Leu His Ser Leu Val Ala Thr Leu Asp Pro Leu Ile 
            4980                4985                4990


Lys Pro Thr Gly Lys Glu Asp Leu Glu Gln Lys Val Ala Ser Leu Glu 
        4995                5000                5005


Leu Arg Ser Gln Arg Met Ser Arg Asp Ser Gly Ala Gln Val Asp Leu 
    5010                5015                5020


Leu Gln Arg Cys Thr Ala Gln Trp His Asp Tyr Gln Lys Ala Arg Glu 
5025                5030                5035                5040


Glu Val Ile Glu Leu Met Asn Asp Thr Glu Lys Lys Leu Ser Glu Phe 
                5045                5050                5055


Ser Leu Leu Lys Thr Ser Ser Ser His Glu Ala Glu Glu Lys Leu Ser 
            5060                5065                5070


Glu His Lys Ala Leu Val Ser Val Val Asn Ser Phe His Glu Lys Ile 
        5075                5080                5085


Val Ala Leu Glu Glu Lys Ala Ser Gln Leu Glu Lys Thr Gly Asn Asp 
    5090                5095                5100


Ala Ser Lys Ala Thr Leu Ser Arg Ser Met Thr Thr Val Trp Gln Arg 
5105                5110                5115                5120


Trp Thr Arg Leu Arg Ala Val Ala Gln Asp Gln Glu Lys Ile Leu Glu 
                5125                5130                5135


Asp Ala Val Asp Glu Trp Thr Gly Phe Asn Asn Lys Val Lys Lys Ala 
            5140                5145                5150


Thr Glu Met Ile Asp Gln Leu Gln Asp Lys Leu Pro Gly Ser Ser Ala 
        5155                5160                5165


Glu Lys Ala Ser Lys Ala Glu Leu Leu Thr Leu Leu Glu Tyr His Asp 
    5170                5175                5180


Thr Phe Val Leu Glu Leu Glu Gln Gln Gln Ser Ala Leu Gly Met Leu 
5185                5190                5195                5200


Arg Gln Gln Thr Leu Ser Met Leu Gln Asp Gly Ala Ala Pro Thr Pro 
                5205                5210                5215


Gly Glu Glu Pro Pro Leu Met Gln Glu Ile Thr Ala Met Gln Asp Arg 
            5220                5225                5230


Cys Leu Asn Met Gln Glu Lys Val Lys Thr Asn Gly Lys Leu Val Lys 
        5235                5240                5245


Gln Glu Leu Lys Asp Arg Glu Met Val Glu Thr Gln Ile Asn Ser Val 
    5250                5255                5260


Lys Cys Trp Val Gln Glu Thr Lys Glu Tyr Leu Gly Asn Pro Thr Ile 
5265                5270                5275                5280


Glu Ile Asp Ala Gln Leu Glu Glu Leu Gln Ile Leu Leu Thr Glu Ala 
                5285                5290                5295


Thr Asn His Arg Gln Asn Ile Glu Lys Met Ala Glu Glu Gln Lys Glu 
            5300                5305                5310


Lys Tyr Leu Gly Leu Tyr Thr Ile Leu Pro Ser Glu Leu Ser Leu Gln 
        5315                5320                5325


Leu Ala Glu Val Ala Leu Asp Leu Lys Ile Arg Asp Gln Ile Gln Asp 
    5330                5335                5340


Lys Ile Lys Glu Val Glu Gln Ser Lys Ala Thr Ser Gln Glu Leu Ser 
5345                5350                5355                5360


Arg Gln Ile Gln Lys Leu Ala Lys Asp Leu Thr Thr Ile Leu Thr Lys 
                5365                5370                5375


Leu Lys Ala Lys Thr Asp Asn Val Val Gln Ala Lys Thr Asp Gln Lys 
            5380                5385                5390


Val Leu Gly Glu Glu Leu Asp Gly Cys Asn Ser Lys Leu Met Glu Leu 
        5395                5400                5405


Asp Ala Ala Val Gln Lys Phe Leu Glu Gln Asn Gly Gln Leu Gly Lys 
    5410                5415                5420


Pro Leu Ala Lys Lys Ile Gly Lys Leu Thr Glu Leu His Gln Gln Thr 
5425                5430                5435                5440


Ile Arg Gln Ala Glu Asn Arg Leu Ser Lys Leu Asn Gln Ala Ala Ser 
                5445                5450                5455


His Leu Glu Glu Tyr Asn Glu Met Leu Glu Leu Ile Leu Lys Trp Ile 
            5460                5465                5470


Glu Lys Ala Lys Val Leu Ala His Gly Thr Ile Ala Trp Asn Ser Ala 
        5475                5480                5485


Ser Gln Leu Arg Glu Gln Tyr Ile Leu His Gln Thr Leu Leu Glu Glu 
    5490                5495                5500


Ser Lys Glu Ile Asp Ser Glu Leu Glu Ala Met Thr Glu Lys Leu Gln 
5505                5510                5515                5520


Tyr Leu Thr Ser Val Tyr Cys Thr Glu Lys Met Ser Gln Gln Val Ala 
                5525                5530                5535


Glu Leu Gly Arg Glu Thr Glu Glu Leu Arg Gln Met Ile Lys Ile Arg 
            5540                5545                5550


Leu Gln Asn Leu Gln Asp Ala Ala Lys Asp Met Lys Lys Phe Glu Ala 
        5555                5560                5565


Glu Leu Lys Lys Leu Gln Ala Ala Leu Glu Gln Ala Gln Ala Thr Leu 
    5570                5575                5580


Thr Ser Pro Glu Val Gly Arg Leu Ser Leu Lys Glu Gln Leu Ser His 
5585                5590                5595                5600


Arg Gln His Leu Leu Ser Glu Met Glu Ser Leu Lys Pro Lys Val Gln 
                5605                5610                5615


Ala Val Gln Leu Cys Gln Ser Ala Leu Arg Ile Pro Glu Asp Val Val 
            5620                5625                5630


Ala Ser Leu Pro Leu Cys His Ala Ala Leu Arg Leu Gln Glu Glu Ala 
        5635                5640                5645


Ser Arg Leu Gln His Thr Ala Ile Gln Gln Cys Asn Ile Met Gln Ala 
    5650                5655                5660


Ala Val Val Gln Tyr Glu Gln Tyr Glu Gln Glu Met Lys His Leu Gln 
5665                5670                5675                5680


Gln Leu Ile Glu Gly Ala His Arg Glu Ile Glu Asp Lys Pro Val Ala 
                5685                5690                5695


Thr Ser Asn Ile Gln Glu Leu Gln Ala Gln Ile Ser Arg His Glu Glu 
            5700                5705                5710


Leu Ala Gln Lys Ile Lys Gly Tyr Gln Glu Gln Ile Ala Ser Leu Asn 
        5715                5720                5725


Ser Lys Cys Lys Met Leu Thr Met Lys Ala Lys His Ala Thr Met Leu 
    5730                5735                5740


Leu Thr Val Thr Glu Val Glu Gly Leu Ala Glu Gly Thr Glu Asp Leu 
5745                5750                5755                5760


Asp Gly Glu Leu Leu Pro Thr Pro Ser Ala His Pro Ser Val Val Met 
                5765                5770                5775


Met Thr Ala Gly Arg Cys His Thr Leu Leu Ser Pro Val Thr Glu Glu 
            5780                5785                5790


Ser Gly Glu Glu Gly Thr Asn Ser Glu Ile Ser Ser Pro Pro Ala Cys 
        5795                5800                5805


Arg Ser Pro Ser Pro Val Ala Asn Thr Asp Ala Ser Val Asn Gln Asp 
    5810                5815                5820


Ile Ala Tyr Tyr Gln Ala Leu Ser Ala Glu Arg Leu Gln Thr Asp Ala 
5825                5830                5835                5840


Ala Lys Ile His Pro Ser Thr Ser Ala Ser Gln Glu Phe Tyr Glu Pro 
                5845                5850                5855


Gly Leu Glu Pro Ser Ala Thr Ala Lys Leu Gly Asp Leu Gln Arg Ser 
            5860                5865                5870


Trp Glu Thr Leu Lys Asn Val Ile Ser Glu Lys Gln Arg Thr Leu Tyr 
        5875                5880                5885


Glu Ala Leu Glu Arg Gln Gln Lys Tyr Gln Asp Ser Leu Gln Ser Ile 
    5890                5895                5900


Ser Thr Lys Met Glu Ala Ile Glu Leu Lys Leu Ser Glu Ser Pro Glu 
5905                5910                5915                5920


Pro Gly Arg Ser Pro Glu Ser Gln Met Ala Glu His Gln Ala Leu Met 
                5925                5930                5935


Asp Glu Ile Leu Met Leu Gln Asp Glu Ile Asn Glu Leu Gln Ser Ser 
            5940                5945                5950


Leu Ala Glu Glu Leu Val Ser Glu Ser Cys Glu Ala Asp Pro Ala Glu 
        5955                5960                5965


Gln Leu Ala Leu Gln Ser Thr Leu Thr Val Leu Ala Glu Arg Met Ser 
    5970                5975                5980


Thr Ile Arg Met Lys Ala Ser Gly Lys Arg Gln Leu Leu Glu Glu Lys 
5985                5990                5995                6000


Leu Asn Asp Gln Leu Glu Glu Gln Arg Gln Glu Gln Ala Leu Gln Arg 
                6005                6010                6015


Tyr Arg Cys Glu Ala Asp Glu Leu Asp Ser Trp Leu Leu Ser Thr Lys 
            6020                6025                6030


Ala Thr Leu Asp Thr Ala Leu Ser Pro Pro Lys Glu Pro Met Asp Met 
        6035                6040                6045


Glu Ala Gln Leu Met Asp Cys Gln Asn Met Leu Val Glu Ile Glu Gln 
    6050                6055                6060


Lys Val Val Ala Leu Ser Glu Leu Ser Val His Asn Glu Asn Leu Leu 
6065                6070                6075                6080


Leu Glu Gly Lys Ala His Thr Lys Asp Glu Ala Glu Gln Leu Ala Gly 
                6085                6090                6095


Lys Leu Arg Arg Leu Lys Gly Ser Leu Leu Glu Leu Gln Arg Ala Leu 
            6100                6105                6110


His Asp Lys Gln Leu Asn Met Gln Gly Thr Ala Gln Glu Lys Glu Glu 
        6115                6120                6125


Ser Asp Val Asp Leu Thr Ala Thr Gln Ser Pro Gly Val Gln Glu Trp 
    6130                6135                6140


Leu Ala Gln Ala Arg Thr Thr Trp Thr Gln Gln Arg Gln Ser Ser Leu 
6145                6150                6155                6160


Gln Gln Gln Lys Glu Leu Glu Gln Glu Leu Ala Glu Gln Lys Ser Leu 
                6165                6170                6175


Leu Arg Ser Val Ala Ser Arg Gly Glu Glu Ile Leu Ile Gln His Ser 
            6180                6185                6190


Ala Ala Glu Thr Ser Gly Asp Ala Gly Glu Lys Pro Asp Val Leu Ser 
        6195                6200                6205


Gln Glu Leu Gly Met Glu Gly Glu Lys Ser Ser Ala Glu Asp Gln Met 
    6210                6215                6220


Arg Met Lys Trp Glu Ser Leu His Gln Glu Phe Ser Thr Lys Gln Lys 
6225                6230                6235                6240


Leu Leu Gln Asn Val Leu Glu Gln Glu Gln Glu Gln Val Leu Tyr Ser 
                6245                6250                6255


Arg Pro Asn Arg Leu Leu Ser Gly Val Pro Leu Tyr Lys Gly Asp Val 
            6260                6265                6270


Pro Thr Gln Asp Lys Ser Ala Val Thr Ser Leu Leu Asp Gly Leu Asn 
        6275                6280                6285


Gln Ala Phe Glu Glu Val Ser Ser Gln Ser Gly Gly Ala Lys Arg Gln 
    6290                6295                6300


Ser Ile His Leu Glu Gln Lys Leu Tyr Asp Gly Val Ser Ala Thr Ser 
6305                6310                6315                6320


Thr Trp Leu Asp Asp Val Glu Glu Arg Leu Phe Val Ala Thr Ala Leu 
                6325                6330                6335


Leu Pro Glu Glu Thr Glu Thr Cys Leu Phe Asn Gln Glu Ile Leu Ala 
            6340                6345                6350


Lys Asp Ile Lys Glu Met Ser Glu Glu Met Asp Lys Asn Lys Asn Leu 
        6355                6360                6365


Phe Ser Gln Ala Phe Pro Glu Asn Gly Asp Asn Arg Asp Val Ile Glu 
    6370                6375                6380


Asp Thr Leu Gly Cys Leu Leu Gly Arg Leu Ser Leu Leu Asp Ser Val 
6385                6390                6395                6400


Val Asn Gln Arg Cys His Gln Met Lys Glu Arg Leu Gln Gln Ile Leu 
                6405                6410                6415


Asn Phe Gln Asn Asp Leu Lys Val Leu Phe Thr Ser Leu Ala Asp Asn 
            6420                6425                6430


Lys Tyr Ile Ile Leu Gln Lys Leu Ala Asn Val Phe Glu Gln Pro Val 
        6435                6440                6445


Ala Glu Gln Ile Glu Ala Ile Gln Gln Ala Glu Asp Gly Leu Lys Glu 
    6450                6455                6460


Phe Asp Ala Gly Ile Ile Glu Leu Lys Arg Arg Gly Asp Lys Leu Gln 
6465                6470                6475                6480


Val Glu Gln Pro Ser Met Gln Glu Leu Ser Lys Leu Gln Asp Met Tyr 
                6485                6490                6495


Asp Glu Leu Met Met Ile Ile Gly Ser Arg Arg Ser Gly Leu Asn Gln 
            6500                6505                6510


Asn Leu Thr Leu Lys Ser Gln Tyr Glu Arg Ala Leu Gln Asp Leu Ala 
        6515                6520                6525


Asp Leu Leu Glu Thr Gly Gln Glu Lys Met Ala Gly Asp Gln Lys Ile 
    6530                6535                6540


Ile Val Ser Ser Lys Glu Glu Ile Gln Gln Leu Leu Asp Lys His Lys 
6545                6550                6555                6560


Glu Tyr Phe Gln Gly Leu Glu Ser His Met Ile Leu Thr Glu Thr Leu 
                6565                6570                6575


Phe Arg Lys Ile Ile Ser Phe Ala Val Gln Lys Glu Thr Gln Phe His 
            6580                6585                6590


Thr Glu Leu Met Ala Gln Ala Ser Ala Val Leu Lys Arg Ala His Lys 
        6595                6600                6605


Arg Gly Val Glu Leu Glu Tyr Ile Leu Glu Thr Trp Ser His Leu Asp 
    6610                6615                6620


Glu Asp Gln Gln Glu Leu Ser Arg Gln Leu Glu Val Val Glu Ser Ser 
6625                6630                6635                6640


Ile Pro Ser Val Gly Leu Val Glu Glu Asn Glu Asp Arg Leu Ile Asp 
                6645                6650                6655


Arg Ile Thr Leu Tyr Gln His Leu Lys Ser Ser Leu Asn Glu Tyr Gln 
            6660                6665                6670


Pro Lys Leu Tyr Gln Val Leu Asp Asp Gly Lys Arg Leu Leu Ile Ser 
        6675                6680                6685


Ile Ser Cys Ser Asp Leu Glu Ser Gln Leu Asn Gln Leu Gly Glu Cys 
    6690                6695                6700


Trp Leu Ser Asn Thr Asn Lys Met Ser Lys Glu Leu His Arg Leu Glu 
6705                6710                6715                6720


Thr Ile Leu Lys His Trp Thr Arg Tyr Gln Ser Glu Ser Ala Asp Leu 
                6725                6730                6735


Ile His Trp Leu Gln Ser Ala Lys Asp Arg Leu Glu Phe Trp Thr Gln 
            6740                6745                6750


Gln Ser Val Thr Val Pro Gln Glu Leu Glu Met Val Arg Asp His Leu 
        6755                6760                6765


Asn Ala Phe Leu Glu Phe Ser Lys Glu Val Asp Ala Gln Ser Ser Leu 
    6770                6775                6780


Lys Ser Ser Val Leu Ser Thr Gly Asn Gln Leu Leu Arg Leu Lys Lys 
6785                6790                6795                6800


Val Asp Thr Ala Thr Leu Arg Ser Glu Leu Ser Arg Ile Asp Ser Gln 
                6805                6810                6815


Trp Thr Asp Leu Leu Thr Asn Ile Pro Ala Val Gln Glu Lys Leu His 
            6820                6825                6830


Gln Leu Gln Met Asp Lys Leu Pro Ser Arg His Ala Ile Ser Glu Val 
        6835                6840                6845


Met Ser Trp Ile Ser Leu Met Glu Asn Val Ile Gln Lys Asp Glu Asp 
    6850                6855                6860


Asn Ile Lys Asn Ser Ile Gly Tyr Lys Ala Ile His Glu Tyr Leu Gln 
6865                6870                6875                6880


Lys Tyr Lys Gly Phe Lys Ile Asp Ile Asn Cys Lys Gln Leu Thr Val 
                6885                6890                6895


Asp Phe Val Asn Gln Ser Val Leu Gln Ile Ser Ser Gln Asp Val Glu 
            6900                6905                6910


Ser Lys Arg Ser Asp Lys Thr Asp Phe Ala Glu Gln Leu Gly Ala Met 
        6915                6920                6925


Asn Lys Ser Trp Gln Ile Leu Gln Gly Leu Val Thr Glu Lys Ile Gln 
    6930                6935                6940


Leu Leu Glu Gly Leu Leu Glu Ser Trp Ser Glu Tyr Glu Asn Asn Val 
6945                6950                6955                6960


Gln Cys Leu Lys Thr Trp Phe Glu Thr Gln Glu Lys Arg Leu Lys Gln 
                6965                6970                6975


Gln His Arg Ile Gly Asp Gln Ala Ser Val Gln Asn Ala Leu Lys Asp 
            6980                6985                6990


Cys Gln Asp Leu Glu Asp Leu Ile Lys Ala Lys Glu Lys Glu Val Glu 
        6995                7000                7005


Lys Ile Glu Gln Asn Gly Leu Ala Leu Ile Gln Asn Lys Lys Glu Asp 
    7010                7015                7020


Val Ser Ser Ile Val Met Ser Thr Leu Arg Glu Leu Gly Gln Thr Trp 
7025                7030                7035                7040


Ala Asn Leu Asp His Met Val Gly Gln Leu Lys Ile Leu Leu Lys Ser 
                7045                7050                7055


Val Leu Asp Gln Trp Ser Ser His Lys Val Ala Phe Asp Lys Ile Asn 
            7060                7065                7070


Ser Tyr Leu Met Glu Ala Arg Tyr Ser Leu Ser Arg Phe Arg Leu Leu 
        7075                7080                7085


Thr Gly Ser Leu Glu Ala Val Gln Val Gln Val Asp Asn Leu Gln Asn 
    7090                7095                7100


Leu Gln Asp Asp Leu Glu Lys Gln Glu Arg Ser Leu Gln Lys Phe Gly 
7105                7110                7115                7120


Ser Ile Thr Asn Gln Leu Leu Lys Glu Cys His Pro Pro Val Thr Glu 
                7125                7130                7135


Thr Leu Thr Asn Thr Leu Lys Glu Val Asn Met Arg Trp Asn Asn Leu 
            7140                7145                7150


Leu Glu Glu Ile Ala Glu Gln Leu Gln Ser Ser Lys Ala Leu Leu Gln 
        7155                7160                7165


Leu Trp Gln Arg Tyr Lys Asp Tyr Ser Lys Gln Cys Ala Ser Thr Val 
    7170                7175                7180


Gln Gln Gln Glu Asp Arg Thr Asn Glu Leu Leu Lys Ala Ala Thr Asn 
7185                7190                7195                7200


Lys Asp Ile Ala Asp Asp Glu Val Ala Thr Trp Ile Gln Asp Cys Asn 
                7205                7210                7215


Asp Leu Leu Lys Gly Leu Gly Thr Val Lys Asp Ser Leu Phe Phe Leu 
            7220                7225                7230


His Glu Leu Gly Glu Gln Leu Lys Gln Gln Val Asp Ala Ser Ala Ala 
        7235                7240                7245


Ser Ala Ile Gln Ser Asp Gln Leu Ser Leu Ser Gln His Leu Cys Ala 
    7250                7255                7260


Leu Glu Gln Ala Leu Cys Lys Gln Gln Thr Ser Leu Gln Ala Gly Val 
7265                7270                7275                7280


Leu Asp Tyr Glu Thr Phe Ala Lys Ser Leu Glu Ala Leu Glu Ala Trp 
                7285                7290                7295


Ile Val Glu Ala Glu Glu Ile Leu Gln Gly Gln Asp Pro Ser His Ser 
            7300                7305                7310


Ser Asp Leu Ser Thr Ile Gln Glu Arg Met Glu Glu Leu Lys Gly Gln 
        7315                7320                7325


Met Leu Lys Phe Ser Ser Met Ala Pro Asp Leu Asp Arg Leu Asn Glu 
    7330                7335                7340


Leu Gly Tyr Arg Leu Pro Leu Asn Asp Lys Glu Ile Lys Arg Met Gln 
7345                7350                7355                7360


Asn Leu Asn Arg His Trp Ser Leu Ile Ser Ser Gln Thr Thr Glu Arg 
                7365                7370                7375


Phe Ser Lys Leu Gln Ser Phe Leu Leu Gln His Gln Thr Phe Leu Glu 
            7380                7385                7390


Lys Cys Glu Thr Trp Met Glu Phe Leu Val Gln Thr Glu Gln Lys Leu 
        7395                7400                7405


Ala Val Glu Ile Ser Gly Asn Tyr Gln His Leu Leu Glu Gln Gln Arg 
    7410                7415                7420


Ala His Glu Leu Phe Gln Ala Glu Met Phe Ser Arg Gln Gln Ile Leu 
7425                7430                7435                7440


His Ser Ile Ile Ile Asp Gly Gln Arg Leu Leu Glu Gln Gly Gln Val 
                7445                7450                7455


Asp Asp Arg Asp Glu Phe Asn Leu Lys Leu Thr Leu Leu Ser Asn Gln 
            7460                7465                7470


Trp Gln Gly Val Ile Arg Arg Ala Gln Gln Arg Arg Gly Ile Ile Asp 
        7475                7480                7485


Ser Gln Ile Arg Gln Trp Gln Arg Tyr Arg Glu Met Ala Glu Lys Leu 
    7490                7495                7500


Arg Lys Trp Leu Val Glu Val Ser Tyr Leu Pro Met Ser Gly Leu Gly 
7505                7510                7515                7520


Ser Val Pro Ile Pro Leu Gln Gln Ala Arg Thr Leu Phe Asp Glu Val 
                7525                7530                7535


Gln Phe Lys Glu Lys Val Phe Leu Arg Gln Gln Gly Ser Tyr Ile Leu 
            7540                7545                7550


Thr Val Glu Ala Gly Lys Gln Leu Leu Leu Ser Ala Asp Ser Gly Ala 
        7555                7560                7565


Glu Ala Ala Leu Gln Ala Glu Leu Ala Glu Ile Gln Glu Lys Trp Lys 
    7570                7575                7580


Ser Ala Ser Met Arg Leu Glu Glu Gln Lys Lys Lys Leu Ala Phe Leu 
7585                7590                7595                7600


Leu Lys Asp Trp Glu Lys Cys Glu Lys Gly Ile Ala Asp Ser Leu Glu 
                7605                7610                7615


Lys Leu Arg Thr Phe Lys Lys Lys Leu Ser Gln Ser Leu Pro Asp His 
            7620                7625                7630


His Glu Glu Leu His Ala Glu Gln Met Arg Cys Lys Glu Leu Glu Asn 
        7635                7640                7645


Ala Val Gly Ser Trp Thr Asp Asp Leu Thr Gln Leu Ser Leu Leu Lys 
    7650                7655                7660


Asp Thr Leu Ser Ala Tyr Ile Ser Ala Asp Asp Ile Ser Ile Leu Asn 
7665                7670                7675                7680


Glu Arg Val Glu Leu Leu Gln Arg Gln Trp Glu Glu Leu Cys His Gln 
                7685                7690                7695


Leu Ser Leu Arg Arg Gln Gln Ile Gly Glu Arg Leu Asn Glu Trp Ala 
            7700                7705                7710


Val Phe Ser Glu Lys Asn Lys Glu Leu Cys Glu Trp Leu Thr Gln Met 
        7715                7720                7725


Glu Ser Lys Val Ser Gln Asn Gly Asp Ile Leu Ile Glu Glu Met Ile 
    7730                7735                7740


Glu Lys Leu Lys Lys Asp Tyr Gln Glu Glu Ile Ala Ile Ala Gln Glu 
7745                7750                7755                7760


Asn Lys Ile Gln Leu Gln Gln Met Gly Glu Arg Leu Ala Lys Ala Ser 
                7765                7770                7775


His Glu Ser Lys Ala Ser Glu Ile Glu Tyr Lys Leu Gly Lys Val Asn 
            7780                7785                7790


Asp Arg Trp Gln His Leu Leu Asp Leu Ile Ala Ala Arg Val Lys Lys 
        7795                7800                7805


Leu Lys Glu Thr Leu Val Ala Val Gln Gln Leu Asp Lys Asn Met Ser 
    7810                7815                7820


Ser Leu Arg Thr Trp Leu Ala His Ile Glu Ser Glu Leu Ala Lys Pro 
7825                7830                7835                7840


Ile Val Tyr Asp Ser Cys Asn Ser Glu Glu Ile Gln Arg Lys Leu Asn 
                7845                7850                7855


Glu Gln Gln Glu Leu Gln Arg Asp Ile Glu Lys His Ser Thr Gly Val 
            7860                7865                7870


Ala Ser Val Leu Asn Leu Cys Glu Val Leu Leu His Asp Cys Asp Ala 
        7875                7880                7885


Cys Ala Thr Asp Ala Glu Cys Asp Ser Ile Gln Gln Ala Thr Arg Asn 
    7890                7895                7900


Leu Asp Arg Arg Trp Arg Asn Ile Cys Ala Met Ser Met Glu Arg Arg 
7905                7910                7915                7920


Leu Lys Ile Glu Glu Thr Trp Arg Leu Trp Gln Lys Phe Leu Asp Asp 
                7925                7930                7935


Tyr Ser Arg Phe Glu Asp Trp Leu Lys Ser Ser Glu Arg Thr Ala Ala 
            7940                7945                7950


Phe Pro Ser Ser Ser Gly Val Ile Tyr Thr Val Ala Lys Glu Glu Leu 
        7955                7960                7965


Lys Lys Phe Glu Ala Phe Gln Arg Gln Val His Glu Cys Leu Thr Gln 
    7970                7975                7980


Leu Glu Leu Ile Asn Lys Gln Tyr Arg Arg Leu Ala Arg Glu Asn Arg 
7985                7990                7995                8000


Thr Asp Ser Ala Cys Ser Leu Lys Gln Met Val His Glu Gly Asn Gln 
                8005                8010                8015


Arg Trp Asp Asn Leu Gln Lys Arg Val Thr Ser Ile Leu Arg Arg Leu 
            8020                8025                8030


Lys His Phe Ile Gly Gln Arg Glu Glu Phe Glu Thr Ala Arg Asp Ser 
        8035                8040                8045


Ile Leu Val Trp Leu Thr Glu Met Asp Leu Gln Leu Thr Asn Ile Glu 
    8050                8055                8060


His Phe Ser Glu Cys Asp Val Gln Ala Lys Ile Lys Gln Leu Lys Ala 
8065                8070                8075                8080


Phe Gln Gln Glu Ile Ser Leu Asn His Asn Lys Ile Glu Gln Ile Ile 
                8085                8090                8095


Ala Gln Gly Glu Gln Leu Ile Glu Lys Ser Glu Pro Leu Asp Ala Ala 
            8100                8105                8110


Ile Ile Glu Glu Glu Leu Asp Glu Leu Arg Arg Tyr Cys Gln Glu Val 
        8115                8120                8125


Phe Gly Arg Val Glu Arg Tyr His Lys Lys Leu Ile Arg Leu Pro Leu 
    8130                8135                8140


Pro Asp Asp Glu His Asp Leu Ser Asp Arg Glu Leu Glu Leu Glu Asp 
8145                8150                8155                8160


Ser Ala Ala Leu Ser Asp Leu His Trp His Asp Arg Ser Ala Asp Ser 
                8165                8170                8175


Leu Leu Ser Pro Gln Pro Ser Ser Asn Leu Ser Leu Ser Leu Ala Gln 
            8180                8185                8190


Pro Leu Arg Ser Glu Arg Ser Gly Arg Asp Thr Pro Ala Ser Val Asp 
        8195                8200                8205


Ser Ile Pro Leu Glu Trp Asp His Asp Tyr Asp Leu Ser Arg Asp Leu 
    8210                8215                8220


Glu Ser Ala Met Ser Arg Ala Leu Pro Ser Glu Asp Glu Glu Gly Gln 
8225                8230                8235                8240


Asp Asp Lys Asp Phe Tyr Leu Arg Gly Ala Val Gly Leu Ser Asp Val 
                8245                8250                8255


Met Ile Pro Glu Ser Pro Glu Ala Tyr Val Lys Leu Thr Glu Asn Ala 
            8260                8265                8270


Ile Lys Asn Thr Ser Gly Asp His Ser Ala Leu Glu Ser Gln Ile Arg 
        8275                8280                8285


Gln Leu Gly Lys Ala Leu Asp Asp Ser Arg Phe Gln Ile Gln Gln Thr 
    8290                8295                8300


Glu Asn Ile Ile Arg Ser Lys Thr Pro Thr Gly Pro Glu Leu Asp Thr 
8305                8310                8315                8320


Ser Tyr Lys Gly Tyr Met Lys Leu Leu Gly Glu Cys Ser Ser Ser Ile 
                8325                8330                8335


Asp Ser Val Lys Arg Leu Glu His Lys Leu Lys Glu Glu Glu Glu Ser 
            8340                8345                8350


Leu Pro Gly Phe Val Asn Leu His Ser Thr Glu Thr Gln Thr Ala Gly 
        8355                8360                8365


Val Ile Asp Arg Trp Glu Leu Leu Gln Ala Gln Ala Leu Ser Lys Glu 
    8370                8375                8380


Leu Arg Met Lys Gln Asn Leu Gln Lys Trp Gln Gln Phe Asn Ser Asp 
8385                8390                8395                8400


Leu Asn Ser Ile Trp Ala Trp Leu Gly Asp Thr Glu Glu Glu Leu Glu 
                8405                8410                8415


Gln Leu Gln Arg Leu Glu Leu Ser Thr Asp Ile Gln Thr Ile Glu Leu 
            8420                8425                8430


Gln Ile Lys Lys Leu Lys Glu Leu Gln Lys Ala Val Asp His Arg Lys 
        8435                8440                8445


Ala Ile Ile Leu Ser Ile Asn Leu Cys Ser Pro Glu Phe Thr Gln Ala 
    8450                8455                8460


Asp Ser Lys Glu Ser Arg Asp Leu Gln Asp Arg Leu Ser Gln Met Asn 
8465                8470                8475                8480


Gly Arg Trp Asp Arg Val Cys Ser Leu Leu Glu Glu Trp Arg Gly Leu 
                8485                8490                8495


Leu Gln Asp Ala Leu Met Gln Cys Gln Gly Phe His Glu Met Ser His 
            8500                8505                8510


Gly Leu Leu Leu Met Leu Glu Asn Ile Asp Arg Arg Lys Asn Glu Ile 
        8515                8520                8525


Val Pro Ile Asp Ser Asn Leu Asp Ala Glu Ile Leu Gln Asp His His 
    8530                8535                8540


Lys Gln Leu Met Gln Ile Lys His Glu Leu Leu Glu Ser Gln Leu Arg 
8545                8550                8555                8560


Val Ala Ser Leu Gln Asp Met Ser Cys Gln Leu Leu Val Asn Ala Glu 
                8565                8570                8575


Gly Thr Asp Cys Leu Glu Ala Lys Glu Lys Val His Val Ile Gly Asn 
            8580                8585                8590


Arg Leu Lys Leu Leu Leu Lys Glu Val Ser Arg His Ile Lys Glu Leu 
        8595                8600                8605


Glu Lys Leu Leu Asp Val Ser Ser Ser Gln Gln Asp Leu Ser Ser Trp 
    8610                8615                8620


Ser Ser Ala Asp Glu Leu Asp Thr Ser Gly Ser Val Ser Pro Thr Ser 
8625                8630                8635                8640


Gly Arg Ser Thr Pro Asn Arg Gln Lys Thr Pro Arg Gly Lys Cys Ser 
                8645                8650                8655


Leu Ser Gln Pro Gly Pro Ser Val Ser Ser Pro His Ser Arg Ser Thr 
            8660                8665                8670


Lys Gly Gly Ser Asp Ser Ser Leu Ser Glu Pro Gly Pro Gly Arg Ser 
        8675                8680                8685


Gly Arg Gly Phe Leu Phe Arg Val Leu Arg Ala Ala Leu Pro Leu Gln 
    8690                8695                8700


Leu Leu Leu Leu Leu Leu Ile Gly Leu Ala Cys Leu Val Pro Met Ser 
8705                8710                8715                8720


Glu Glu Asp Tyr Ser Cys Ala Leu Ser Asn Asn Phe Ala Arg Ser Phe 
                8725                8730                8735


His Pro Met Leu Arg Tyr Thr Asn Gly Pro Pro Pro Leu 
            8740                8745


<210>  388
<211>  3894
<212>  DNA
<213>  Homo sapiens

<400>  388
aaggtaaagc cactagagag aaactgaaag aaaacattct taagataaat tgaattgaca     60

ttttctctct aaaatatgat ttatagacca cagataggaa ttaagagttt cctgataatt    120

ttggcttcat attattttaa aggattatca agaggaaatt gctattgctc aagagaacaa    180

aatacagctc caacaaatgg gagaacgact tgctaaagcc agccatgaaa gcaaagcatc    240

tgagattgaa tacaagctgg gaaaggtcaa cgaccggtgg cagcatctcc tggacctcat    300

tgcagccagg gtgaagaagc tgaaggagac cctggtagcc gtgcagcagc ttgataagaa    360

catgagcagc ctgaggacct ggctcgctca catcgagtca gagctggcca agccaatagt    420

ctacgattcc tgtaactcgg aagaaataca gagaaagctt aatgagcagc aggagcttca    480

gagagacata gagaagcaca gtacaggtgt tgcatctgtc ctcaacctgt gtgaagtcct    540

gctgcacgac tgtgacgcct gtgccactga tgccgagtgt gactctatac agcaggctac    600

gagaaacctg gaccggcggt ggagaaacat ttgtgctatg tccatggaaa ggaggctgaa    660

aatcgaagag acgtggcgat tgtggcagaa atttctggat gactattcac gttttgaaga    720

ttggctgaag tcttcagaaa ggacagctgc ttttcccagc tcttctgggg tgatctatac    780

agttgccaag gaagaactaa agaaatttga ggctttccag cgacaggtcc acgagtgcct    840

gacgcagctg gaactgatca acaagcagta ccgccgcctg gccagggaga accgcactga    900

ttcagcatgt agcctcaaac agatggttca cgaaggcaac cagagatggg acaacctgca    960

aaagcgtgtc acctccatct tgcgcagact caagcatttt attggccagc gtgaggagtt   1020

tgagactgcg cgggacagca ttctggtctg gctcacagag atggatctgc agctcactaa   1080

tattgaacat ttttctgagt gtgatgttca agctaaaata aagcaactca aggccttcca   1140

gcaggaaatt tcactgaacc acaataagat tgagcagata attgcccaag gagaacagct   1200

gatagaaaag agtgagccct tggatgcagc gatcatcgag gaggaactag atgagctccg   1260

acggtactgc caggaggtct tcgggcgtgt ggaaagatac cataagaaac tgatccgcct   1320

gcctctccca gacgatgagc acgacctctc agacagggag ctggagctgg aagactctgc   1380

agctctgtcg gacctgcact ggcacgaccg ctctgcagac agcctgcttt ctccacagcc   1440

ttcctccaat ctctccctct cgctcgctca gcccctccgg agcgagcggt caggacgaga   1500

caccccggct agtgtggact ccatccccct ggagtgggat cacgactatg acctcagtcg   1560

ggacctggag tctgcaatgt ccagagctct gccctctgag gatgaagaag gtcaggatga   1620

caaagatttc tacctccggg gagctgttgg cttatcagat gtaatgatcc ccgaaagccc   1680

tgaggcctat gtaaaactca cagaaaatgc aatcaaaaat acctccgggg accacagtgc   1740

cctagagtca cagatccgac aactgggcaa agccctggat gatagccgtt ttcagataca   1800

gcaaaccgaa aatatcattc gcagcaaaac tcccacgggg ccggagctag acaccagcta   1860

caaaggctac atgaaactgc tgggcgaatg cagtagcagt atagactccg tgaagagact   1920

ggagcacaaa ctgaaggagg aagaggagag ccttcctggc tttgttaacc tgcatagtac   1980

cgaaacccaa acggctggtg tgattgaccg atgggagctt ctccaggccc aggcattgag   2040

caaggagttg aggatgaagc agaacctcca gaagtggcag cagtttaact cagacttgaa   2100

cagcatctgg gcctggctgg gggacacgga ggaggagttg gaacagctcc agcgtctgga   2160

actcagcact gacatccaga ccatcgagct ccagatcaaa aagctcaagg agctccagaa   2220

agctgtggac caccgcaaag ccatcatcct ctccatcaat ctctgcagcc ctgagttcac   2280

ccaggctgac agcaaggaga gccgggacct gcaggatcgc ttgtcgcaga tgaatgggcg   2340

ctgggaccga gtgtgctctc tgctggagga gtggcggggc ctgctgcagg atgccctgat   2400

gcagtgccag ggtttccatg aaatgagcca tggtttgctt cttatgctgg agaacattga   2460

cagaaggaaa aatgaaattg tccctattga ttctaacctt gatgcagaga tacttcagga   2520

ccatcacaaa cagcttatgc aaataaagca tgagctgttg gaatcccaac tcagagtagc   2580

ctctttgcaa gacatgtctt gccaactact ggtgaatgct gaaggaacag actgtttaga   2640

agccaaagaa aaagtccatg ttattggaaa tcggctcaaa cttctcttga aggaggtcag   2700

tcgtcatatc aaggaactgg agaagttatt agacgtgtca agtagtcagc aggatttgtc   2760

ttcctggtct tctgctgatg aactggacac ctcagggtct gtgagtccca catcaggaag   2820

gagcacccca aacagacaga aaacgccacg aggcaagtgt agtctctcac agcctggacc   2880

ctctgtcagc agtccacata gcaggtccac aaaaggtggc tccgattcct ccctttctga   2940

gccagggcca ggtcggtccg gccgcggctt cctgttcaga gtcctccgag cagctcttcc   3000

ccttcagctt ctcctgctcc tcctcatcgg gcttgcctgc cttgtaccaa tgtcagagga   3060

agactacagc tgtgccctct ccaacaactt tgcccggtca ttccacccca tgctcagata   3120

cacgaatggc cctcctccac tctgaactaa gcagatgcca tctgcagaag tgctggtagc   3180

ataaggagga tcgggtcata agcaatccca aactaccaac aagaggacct tgatcttggc   3240

gaaagccctc ggtgtggcag ctttagccct cctccagatc acatgtgtgc aaattatggc   3300

ttcagaggtg gaagataaac agtgacgggg gaacaaacag acaacaagaa ggtttggaag   3360

aaatctggtt tgagactctg aaccttagca ctaaggagat tgagtaagga cctccaaagt   3420

tccccggact catgaattct gggcccttgg cccattctgt gcacagccaa ggacttcagt   3480

agaccatctg ggcagctttc ccatggtgct gctccaacca tcagataaat gaccctccca   3540

agcaccatgt cagtgtcgta caatctacca accaaccagt gctgaagaga ttttagaacc   3600

ttgtaacata caatttttaa gagcttatat ggcagcttcc tttttacctt gttttccttt   3660

ggggcatgat gttttaacct ttgctttaga agcacaagct gtaaatctaa aaggcacttt   3720

tttttagagg tataaagaaa aactagatgt aataaataag atcatggaag gctttatgtg   3780

aaaaaagttg aatgttatag taaaaaaaaa aagatattta tgtatgtaca gtttgctaaa   3840

gccaagtttt gtttgtattg atttctttgc atttattata gatattataa aata         3894


<210>  389
<211>  982
<212>  PRT
<213>  Homo sapiens

<400>  389

Met Gly Glu Arg Leu Ala Lys Ala Ser His Glu Ser Lys Ala Ser Glu 
1               5                   10                  15


Ile Glu Tyr Lys Leu Gly Lys Val Asn Asp Arg Trp Gln His Leu Leu 
            20                  25                  30


Asp Leu Ile Ala Ala Arg Val Lys Lys Leu Lys Glu Thr Leu Val Ala 
        35                  40                  45


Val Gln Gln Leu Asp Lys Asn Met Ser Ser Leu Arg Thr Trp Leu Ala 
    50                  55                  60


His Ile Glu Ser Glu Leu Ala Lys Pro Ile Val Tyr Asp Ser Cys Asn 
65                  70                  75                  80


Ser Glu Glu Ile Gln Arg Lys Leu Asn Glu Gln Gln Glu Leu Gln Arg 
                85                  90                  95


Asp Ile Glu Lys His Ser Thr Gly Val Ala Ser Val Leu Asn Leu Cys 
            100                 105                 110


Glu Val Leu Leu His Asp Cys Asp Ala Cys Ala Thr Asp Ala Glu Cys 
        115                 120                 125


Asp Ser Ile Gln Gln Ala Thr Arg Asn Leu Asp Arg Arg Trp Arg Asn 
    130                 135                 140


Ile Cys Ala Met Ser Met Glu Arg Arg Leu Lys Ile Glu Glu Thr Trp 
145                 150                 155                 160


Arg Leu Trp Gln Lys Phe Leu Asp Asp Tyr Ser Arg Phe Glu Asp Trp 
                165                 170                 175


Leu Lys Ser Ser Glu Arg Thr Ala Ala Phe Pro Ser Ser Ser Gly Val 
            180                 185                 190


Ile Tyr Thr Val Ala Lys Glu Glu Leu Lys Lys Phe Glu Ala Phe Gln 
        195                 200                 205


Arg Gln Val His Glu Cys Leu Thr Gln Leu Glu Leu Ile Asn Lys Gln 
    210                 215                 220


Tyr Arg Arg Leu Ala Arg Glu Asn Arg Thr Asp Ser Ala Cys Ser Leu 
225                 230                 235                 240


Lys Gln Met Val His Glu Gly Asn Gln Arg Trp Asp Asn Leu Gln Lys 
                245                 250                 255


Arg Val Thr Ser Ile Leu Arg Arg Leu Lys His Phe Ile Gly Gln Arg 
            260                 265                 270


Glu Glu Phe Glu Thr Ala Arg Asp Ser Ile Leu Val Trp Leu Thr Glu 
        275                 280                 285


Met Asp Leu Gln Leu Thr Asn Ile Glu His Phe Ser Glu Cys Asp Val 
    290                 295                 300


Gln Ala Lys Ile Lys Gln Leu Lys Ala Phe Gln Gln Glu Ile Ser Leu 
305                 310                 315                 320


Asn His Asn Lys Ile Glu Gln Ile Ile Ala Gln Gly Glu Gln Leu Ile 
                325                 330                 335


Glu Lys Ser Glu Pro Leu Asp Ala Ala Ile Ile Glu Glu Glu Leu Asp 
            340                 345                 350


Glu Leu Arg Arg Tyr Cys Gln Glu Val Phe Gly Arg Val Glu Arg Tyr 
        355                 360                 365


His Lys Lys Leu Ile Arg Leu Pro Leu Pro Asp Asp Glu His Asp Leu 
    370                 375                 380


Ser Asp Arg Glu Leu Glu Leu Glu Asp Ser Ala Ala Leu Ser Asp Leu 
385                 390                 395                 400


His Trp His Asp Arg Ser Ala Asp Ser Leu Leu Ser Pro Gln Pro Ser 
                405                 410                 415


Ser Asn Leu Ser Leu Ser Leu Ala Gln Pro Leu Arg Ser Glu Arg Ser 
            420                 425                 430


Gly Arg Asp Thr Pro Ala Ser Val Asp Ser Ile Pro Leu Glu Trp Asp 
        435                 440                 445


His Asp Tyr Asp Leu Ser Arg Asp Leu Glu Ser Ala Met Ser Arg Ala 
    450                 455                 460


Leu Pro Ser Glu Asp Glu Glu Gly Gln Asp Asp Lys Asp Phe Tyr Leu 
465                 470                 475                 480


Arg Gly Ala Val Gly Leu Ser Asp Val Met Ile Pro Glu Ser Pro Glu 
                485                 490                 495


Ala Tyr Val Lys Leu Thr Glu Asn Ala Ile Lys Asn Thr Ser Gly Asp 
            500                 505                 510


His Ser Ala Leu Glu Ser Gln Ile Arg Gln Leu Gly Lys Ala Leu Asp 
        515                 520                 525


Asp Ser Arg Phe Gln Ile Gln Gln Thr Glu Asn Ile Ile Arg Ser Lys 
    530                 535                 540


Thr Pro Thr Gly Pro Glu Leu Asp Thr Ser Tyr Lys Gly Tyr Met Lys 
545                 550                 555                 560


Leu Leu Gly Glu Cys Ser Ser Ser Ile Asp Ser Val Lys Arg Leu Glu 
                565                 570                 575


His Lys Leu Lys Glu Glu Glu Glu Ser Leu Pro Gly Phe Val Asn Leu 
            580                 585                 590


His Ser Thr Glu Thr Gln Thr Ala Gly Val Ile Asp Arg Trp Glu Leu 
        595                 600                 605


Leu Gln Ala Gln Ala Leu Ser Lys Glu Leu Arg Met Lys Gln Asn Leu 
    610                 615                 620


Gln Lys Trp Gln Gln Phe Asn Ser Asp Leu Asn Ser Ile Trp Ala Trp 
625                 630                 635                 640


Leu Gly Asp Thr Glu Glu Glu Leu Glu Gln Leu Gln Arg Leu Glu Leu 
                645                 650                 655


Ser Thr Asp Ile Gln Thr Ile Glu Leu Gln Ile Lys Lys Leu Lys Glu 
            660                 665                 670


Leu Gln Lys Ala Val Asp His Arg Lys Ala Ile Ile Leu Ser Ile Asn 
        675                 680                 685


Leu Cys Ser Pro Glu Phe Thr Gln Ala Asp Ser Lys Glu Ser Arg Asp 
    690                 695                 700


Leu Gln Asp Arg Leu Ser Gln Met Asn Gly Arg Trp Asp Arg Val Cys 
705                 710                 715                 720


Ser Leu Leu Glu Glu Trp Arg Gly Leu Leu Gln Asp Ala Leu Met Gln 
                725                 730                 735


Cys Gln Gly Phe His Glu Met Ser His Gly Leu Leu Leu Met Leu Glu 
            740                 745                 750


Asn Ile Asp Arg Arg Lys Asn Glu Ile Val Pro Ile Asp Ser Asn Leu 
        755                 760                 765


Asp Ala Glu Ile Leu Gln Asp His His Lys Gln Leu Met Gln Ile Lys 
    770                 775                 780


His Glu Leu Leu Glu Ser Gln Leu Arg Val Ala Ser Leu Gln Asp Met 
785                 790                 795                 800


Ser Cys Gln Leu Leu Val Asn Ala Glu Gly Thr Asp Cys Leu Glu Ala 
                805                 810                 815


Lys Glu Lys Val His Val Ile Gly Asn Arg Leu Lys Leu Leu Leu Lys 
            820                 825                 830


Glu Val Ser Arg His Ile Lys Glu Leu Glu Lys Leu Leu Asp Val Ser 
        835                 840                 845


Ser Ser Gln Gln Asp Leu Ser Ser Trp Ser Ser Ala Asp Glu Leu Asp 
    850                 855                 860


Thr Ser Gly Ser Val Ser Pro Thr Ser Gly Arg Ser Thr Pro Asn Arg 
865                 870                 875                 880


Gln Lys Thr Pro Arg Gly Lys Cys Ser Leu Ser Gln Pro Gly Pro Ser 
                885                 890                 895


Val Ser Ser Pro His Ser Arg Ser Thr Lys Gly Gly Ser Asp Ser Ser 
            900                 905                 910


Leu Ser Glu Pro Gly Pro Gly Arg Ser Gly Arg Gly Phe Leu Phe Arg 
        915                 920                 925


Val Leu Arg Ala Ala Leu Pro Leu Gln Leu Leu Leu Leu Leu Leu Ile 
    930                 935                 940


Gly Leu Ala Cys Leu Val Pro Met Ser Glu Glu Asp Tyr Ser Cys Ala 
945                 950                 955                 960


Leu Ser Asn Asn Phe Ala Arg Ser Phe His Pro Met Leu Arg Tyr Thr 
                965                 970                 975


Asn Gly Pro Pro Pro Leu 
            980


<210>  390
<211>  27745
<212>  DNA
<213>  Homo sapiens

<400>  390
cccgggcagt ggaaaccgtg ggcaaaagtt agctggcagg acagcgcagc tcctccaggc     60

agcggaggca gcgcgtcccg gctctcaggg acatttcctt cccacctcga cccccgggag    120

gtggtcccgg tataaaggct cgctgagcgg gtgggtcaca gcacagcttt gcagctgcgg    180

agaaacgccc aaggccgtgc atctccagga gggcggctgg gctcccgcag tcctgcagac    240

cgcgcccgat cccggcgaca gggcgggcgg acagccgcgc atccccgggg tcccgccgag    300

cctgggcgca gagagccggg aggaagcgtt cgctcgcttc gccttgctgc tgggaaactg    360

aacgaggccg agagagaagg ttcttgagtt catgtaagag gacagtctta aaacggaaga    420

agaaaaagaa gcagttcagt ctttgggaga gctgcctcct tgttgagtgc tgcaaaggcc    480

tggaattcat ttatgacaga atagatctag aaaagtccaa gcatgttttc tagagtggtg    540

tagccctgtg ctgcctccag tgaagagtct cttggtgttg gcttcgtgct tccggaggga    600

ccatggcaac ctccagaggg gcctcccggt gtcctcggga tatcgccaat gtgatgcaga    660

ggctgcaaga tgagcaagag atagtacaaa aacgaacttt cacaaaatgg atcaactctc    720

atctggccaa gcggaaacct ccaatggtgg tggacgatct ttttgaagac atgaaagatg    780

gtgttaaact gcttgccctt ctggaggtcc tgtctgggca gaaactgcct tgtgaacaag    840

gacgccggat gaagcgaatc catgctgtgg ctaacattgg cacggcactc aagttcctcg    900

aaggaagaaa gattaaatta gtcaacatta actccaccga tatagctgat ggccgaccct    960

caatagttct tggattgatg tggaccatta ttctatattt ccagattgaa gagttgacca   1020

gcaacctgcc ccagctccag tctttgtcca gcagcgcatc ctccgtggac agcatagtta   1080

gctctgagac tcccagccca ccaagtaaac ggaaggtgac caccaagatc caaggaaatg   1140

ctaagaaggc tttattaaag tgggttcagt acacagctgg caagcagact ggaatagaag   1200

taaaagattt tgggaagagt tggagaagcg gggttgcctt tcattcagtt attcatgcca   1260

ttcgaccgga attggtggac ttggagacag tgaaaggcag atccaaccga gaaaatttgg   1320

aggatgcttt cactatcgcc gaaacagaac tggggatccc aagactgcta gatcctgaag   1380

acgttgatgt ggataaacca gatgagaaat ctattatgac ctatgtagcc cagtttctga   1440

aacattatcc tgacatccac aatgcaagca ctgatgggca agaggatgat gaaatacttc   1500

caggtttccc atcttttgca aattctgtac aaaattttaa gagagaagac agagtaattt   1560

ttaaggaaat gaaagtttgg atagaacaat ttgagagaga tttgacaaga gcacagatgg   1620

tggaatcaaa tttacaggat aaatatcagt catttaagca cttcagagtt caatatgaaa   1680

tgaagaggaa acagattgaa catttaatac aaccattaca cagagacggt aaattgtcac   1740

ttgaccaagc attggtaaaa caatcttggg atagagtgac ctccaggctc tttgactggc   1800

atatacagct tgataaatct cttcctgcac ctctgggcac cataggtgcc tggctgtaca   1860

gagcggaggt ggccctgaga gaggaaataa ccgttcaaca ggtccacgag gaaacagcaa   1920

acacgataca acggaaactt gagcaacata aggatctgct tcaaaacacg gatgcccaca   1980

aaagagcatt ccatgaaatc taccggacca ggtctgttaa cgggattcca gtgccacctg   2040

atcaattaga ggacatggcc gagaggtttc attttgtttc ctccacatca gagctacacc   2100

taatgaaaat ggaattttta gaattaaagt accgtctgct ctcactgctg gttcttgcag   2160

agtcaaagct gaagtcttgg atcattaagt acgggaggag agagtcagtg gagcagcttc   2220

tacaaaacta cgtgtctttt atagaaaata gcaagttctt tgaacaatat gaggtgacat   2280

accagatctt gaaacagaca gctgagatgt atgtcaaagc agatggttca gtggaagaag   2340

ctgagaatgt gatgaaattc atgaatgaaa ccaccgctca gtggaggaat ctctcagtag   2400

aagtgaggag tgtgaggagc atgctggaag aagtgatctc taactgggat cgctatggca   2460

atacagtggc tagtctgcaa gcctggctag aggatgctga aaaaatgctc aatcaatcag   2520

aaaatgccaa aaaggatttt tttcgaaatt tacctcattg gattcagcag catactgcca   2580

tgaacgatgc tggcaatttt ctaattgaaa cctgtgatga gatggtttcc cgtgacctga   2640

agcagcaatt actgttgcta aatgggcggt ggagggagtt gtttatggaa gtcaagcaat   2700

atgctcaagc tgatgagatg gacagaatga agaaggaata cacagactgt gttgttaccc   2760

tgtctgcttt tgcaacggaa gcccataaga aactttctga acccttagaa gtctctttta   2820

tgaatgtcaa gctattaatt caagacttgg aggatattga gcagagggtg cctgtgatgg   2880

atgcccaata caagataatt acaaagacag cacacctcat taccaaagaa agcccccaag   2940

aagaaggaaa agaaatgttt gcgaccatgt caaagctcaa agagcagcta accaaggtca   3000

aagaatgtta ctccccactc ctttatgagt ctcagcagct gttgattccg ttggaggaat   3060

tagaaaagca gatgacgtcc ttttatgact cacttgggaa aatcaatgaa attatcacag   3120

ttcttgagcg tgaggcacaa tcgagtgccc tttttaaaca aaaacatcag gaactgttag   3180

cttgtcaaga aaactgtaag aaaaccttga cacttattga gaaaggcagt caaagtgttc   3240

aaaagtttgt gaccttgagc aacgtgttaa agcattttga tcagacgagg ctacaaagac   3300

agattgcaga tattcatgtt gcttttcaga gtatggtaaa gaaaactgga gattggaaga   3360

agcatgtgga aaccaacagt cgcttgatga agaagtttga ggagtctcga gcagagttgg   3420

agaaggtact gcggattgct caggagggcc tggaggaaaa gggggatcca gaggagctcc   3480

tgcggagaca cactgagttt ttcagtcagc tggatcagag ggtgctcaat gctttcctga   3540

aagcttgtga tgaactcacc gacatccttc cagagcagga gcagcagggg ctgcaggaag   3600

ctgttcgaaa gctccacaaa caatggaagg atcttcaagg agaagcccct tatcatttgc   3660

ttcatctgaa gattgatgtg gagaagaata ggttcttagc ctctgtagaa gaatgcagaa   3720

ctgagctgga tcgagagacc aagctgatgc cccaggaagg cagtgaaaag ataattaaag   3780

agcacagggt tttcttcagt gacaaaggtc ctcatcatct ctgtgagaaa aggttacagc   3840

tcatcgagga actctgtgtg aaactcccag tgcgggaccc agtaagggac acacctggaa   3900

cctgtcacgt gactctcaaa gagctcagag ctgccattga cagcacctac aggaagctca   3960

tggaagaccc agacaagtgg aaggactaca ctagcagatt ctctgagttc tcatcttgga   4020

tatctacaaa tgagacacaa ttaaagggga tcaagggtga ggccatcgat actgccaacc   4080

acggagaggt taaacgtgcc gttgaagaga tcagaaatgg tgttaccaaa aggggtgaga   4140

ccctcagctg gctgaaatcc aggctgaaag ttttgacaga agtttcttct gagaatgaag   4200

cccaaaagca gggagatgag ctggcaaaat tatccagctc tttcaaggct cttgtgacgc   4260

tgctgtcaga ggttgaaaag atgctaagca attttgggga ctgtgtccag tacaaagaaa   4320

tagtcaaaaa ttctctcgaa gaattaattt ctggctctaa agaagtccag gaacaagctg   4380

agaagatctt ggatactgaa aatctgtttg aagcacagca gttacttctt catcaccagc   4440

aaaagacaaa gcggatctca gcaaagaaga gagatgtgca gcagcagatc gcgcaggcgc   4500

agcagggaga aggggggctg cctgaccgag gccacgagga gctgcggaag ctggagagca   4560

cactggatgg cctggagcgc agccgggaga ggcaggaacg ccgcatccag gtcacattaa   4620

gaaaatggga gcgatttgaa acaaacaaag aaacagtagt aagatacctt tttcaaacag   4680

gttccagtca tgaacgcttc ttgagtttta gcagtttgga aagtttatct tcagaactgg   4740

aacaaacaaa ggagttttct aaacggacag aaagtattgc agtccaggct gagaaccttg   4800

taaaggaagc ttcagagata ccgcttgggc cccaaaataa gcagctgctt caacagcagg   4860

ccaagtcaat caaagaacaa gtcaaaaaat tagaagacac gcttgaagaa gatattaaaa   4920

ccatggaaat ggtgaaaacc aagtgggatc attttggcag taattttgag actctgtccg   4980

tctggataac tgagaaagaa aaagaactca atgccttgga aacttcgtca tctgccatgg   5040

acatgcaaat cagccaaatt aaggtcacaa ttcaggaaat agaaagtaag ctcagcagca   5100

ttgtaggatt agaagaagaa gcccagtctt ttgctcagtt tgttaccact ggagaatctg   5160

ctcgaattaa agccaagttg acacaaataa gaagatacgg ggaagagctt cgagagcatg   5220

cacagtgtct ggaaggaaca atcctgggac atttatctca gcagcaaaag tttgaagaga   5280

accttagaaa gatccagcaa tctgtgtctg aatttgaaga taaacttgct gttccaatta   5340

aaatatgttc ttcagctaca gaaacataca aagttcttca agaacatatg gatctctgcc   5400

aggccctgga gtcactgagc agcgcgatca ctgccttctc agccagtgcc aggaaggttg   5460

tgaacagaga ttcctgtgtt caggaggctg cggctctaca gcagcaatac gaggacatcc   5520

taaggagggc gaaggagaga cagacggcgc tggagaatct gctggcccac tggcagaggc   5580

tagagaaaga actatcatcc tttttgacct ggttagagcg gggtgaagct aaagccagtt   5640

ccccagaaat ggacatttct gcagacagag tcaaagtgga aggtgaactt cagttaatac   5700

aggcactgca aaatgaagtt gtatcccagg cctcattcta tagcaaactt ttgcaattga   5760

aggaatcatt gttctcagta gcctccaaag atgatgtgaa aatgatgaaa ctacatttgg   5820

agcagttgga tgagagatgg agagatttac cacagatcat taacaaaagg attaattttc   5880

ttcagtctgt ggttgctgaa caccagcaat ttgatgagct gctgctttcc ttttctgtct   5940

ggattaaact gtttctcagt gaattacaaa ctacctctga gattagcata atggaccatc   6000

aagtagccct tactcggcat aaggaccacg cagcagaagt agagagcaaa aagggcgaat   6060

tgcagagtct gcagggtcac ttagcaaagt tgggttctct gggccgtgct gaggacctcc   6120

acctcctgca gggaaaggct gaggactgct tccagctgtt tgaggaggcc agccaggttg   6180

tggagaggcg gcagcttgcc ctgtcccatt tggcagaatt cctccagagc catgcctctc   6240

tgtccggcat tctccgccag ctgaggcaaa cagtggaagc aaccaacagt atgaataaga   6300

acgagtctga tttgatagaa aaggacctca atgatgctct tcaaaatgct aaagcattag   6360

aatctgctgc cgtcagtctg gatggcattc tttccaaagc ccaataccat ctgaaaatcg   6420

ggagctctga gcaaaggact tcctgcagag ccacggctga tcagctctgt ggagaggtag   6480

agaggatcca gaaccttctg ggaaccaagc agagtgaggc agatgctctg gcagtgttga   6540

aaaaagcatt ccaagaccag aaagaggagc ttctgaaaag cattgaggac attgaagaaa   6600

ggactgacaa agagcgattg aaagaaccta cccgccaagc tcttcagcag aggttaagag   6660

tgtttaatca gctagaagat gaattgaatt ctcacgagca tgaactatgt tggttgaaag   6720

acaaagccaa gcaaattgcc cagaaagatg tagcttttgc acctgaagtt gacagggaga   6780

taaaccgctt agaggtcacc tgggatgata ccaaaagact aattcatgaa aatcagggtc   6840

agtgctgtgg acttattgac ttaatgagag aatatcagaa cctgaaatca gctgtatcta   6900

aagtcttaga aaatgccagc agtgtgattg taaccagaac taccataaaa gatcaggagg   6960

atcttaaatg ggctttttcc aagcatgaaa ctgccaagaa caaaatgaat tacaaacaga   7020

aagacttgga taactttacc agcaaaggaa aacacttgtt atctgagctg aagaaaattc   7080

acagtagtga tttcagcttg gtgaaaacag acatggagag caccgtggac aaatggctgg   7140

atgtatcaga gaaacttgaa gaaaacatgg ataggctgag agtaagcctg tccatttggg   7200

atgatgtact gtcaactaga gatgagattg agggatggtc aaacaactgc gttccacaga   7260

tggcagaaaa catcagcaac ctggataacc acctcagagc tgaagaactg cttaaagaat   7320

ttgagtctga agttaaaaac aaagcattga gattggaaga actgcattcc aaagttaatg   7380

atctgaaaga attaactaaa aatctagaaa caccgccaga ccttcagttt atagaagcag   7440

acttaatgca gaaactggag catgccaaag aaataactga agtagcaaaa ggaaccctga   7500

aggatttcac ggctcaaagt acacaagtgg agaagtttat taatgacata acaacatggt   7560

tcacaaaagt ggaagaatcg ttgatgaact gtgcccaaaa tgagacttgt gaagcattga   7620

aaaaagtcaa ggatatacaa aaagaacttc aaagtcaaca aagcaacatc agctctaccc   7680

aagaaaatct caatagcttg tgccgcaagt accactcagc tgagttggag agcctgggcc   7740

gtgcaatgac tggtctgata aagaaacatg aagccgtgag ccagttgtgc tccaaaaccc   7800

aggccagcct gcaggaatct ctggaaaaac acttcagtga gtctatgcag gaattccaag   7860

aatggttttt gggagcaaag gcagcagcaa aagaatcatc agatcgcacc ggtgacagca   7920

aagttctaga agcaaagctc catgatcttc agaacatttt ggactcagtc agtgatgggc   7980

agagcaaact tgatgcagtg actcaagaag gacaaacttt gtatgcacat ttgtctaaac   8040

aaattgtcag tagcattcaa gaacaaatca caaaggccaa tgaagagttt caagcatttc   8100

tgaaacaatg ccttaaagat aagcaggctc ttcaagactg tgcttcagaa cttggaagct   8160

ttgaagatca gcacagaaaa ctgaacttat ggatccatga aatggaagaa aggttcaata   8220

cggaaaactt gggagagagt aaacagcaca ttcctgagaa gaaaaatgaa gttcataaag   8280

ttgaaatgtt tttgggagaa ctgctggctg caagagagtc tcttgataag ctttcccaga   8340

gagggcagct tctgagtgaa gaaggccacg gtgctgggca ggagggccgc ctgtgttccc   8400

agctcctcac aagccaccag aacctactta gaatgaccaa agagaaactc cggagctgcc   8460

aggtggccct tcaggagcac gaagccctgg aggaagcact gcaaagcatg tggttctggg   8520

tgaaggccat tcaggacaga ctggcctgtg cagagagcac tcttgggagc aaagacaccc   8580

tggagaaacg gctgtcacaa atacaggata ttctcctgat gaaaggtgaa ggggaagtta   8640

agttgaatat ggccattggc aagggggaac aggccttgag aagtagcaac aaagaaggtc   8700

agagggtgat tcagactcag ttagagaccc ttaaagaagt gtgggctgac atcatgagct   8760

cctccgtcca cgctcaaagc actttagagt ctgtgattag ccaatggaat gactatgtag   8820

agaggaaaaa ccagttggag cagtggatgg aatcagtgga tcaaaaaata gaacatccct   8880

tacaaccaca gccaggtctg aaagagaagt tcgtcctgct tgaccacctc cagtccatcc   8940

tgtctgaggc agaagatcac acgagagccc ttcaccgtct aattgcgaag tccagggagc   9000

tctacgaaaa gacagaggat gagtctttca aggacacagc tcaagaggag ctgaaaacac   9060

agtttaatga tataatgact gttgccaagg aaaaaatgag gaaagtggaa gagattgtga   9120

aagatcatct aatgtattta gatgcggtcc acgagttcac agattggctc cattcagcaa   9180

aggaagaact tcaccggtgg tcagatatgt ctggagattc atcagccacc cagaaaaagt   9240

tatcaaaaat taaggagctg atagattcca gagagattgg tgcaagccgt ctcagcagag   9300

tggagtcgct ggctcccgaa gtgaaacaga acacaactgc cagtgggtgt gagctcatgc   9360

acacggagat gcaggccctg cgtgccgact ggaagcagtg ggaagacagt gtattccaaa   9420

cgcagagctg tttggagaac ctggtcagcc agatggccct ttcggagcag gaattctcag   9480

gccaagtggc tcaactggag caggccctgg aacagttcag tgcccttctg aaaacctggg   9540

ctcagcagtt aaccctcctg gaaggcaaga acacggatga ggagatagtg gaatgctggc   9600

acaaaggaca agagatactg gatgctttgc aaaaagcaga gcctagaaca gaggatctca   9660

agtctcagct gaatgaactt tgtcgatttt ccagagacct gagtacctac agtggaaaag   9720

tttctggctt gattaaagag tataattgtc tttgtttgca agcatccaag ggctgccaga   9780

ataaagaaca gattttacag caaagatttc gaaaggcctt cagggatttc cagcagtggt   9840

tggttaatgc aaaaatcact accgccaagt gttttgatat acctcaaaat ataagtgaag   9900

tttcaactag tcttcagaaa atacaggagt ttttgtcaga aagtgaaaat ggacagcaca   9960

agctaaacat gatgctgtct aaaggggaac ttctgagtac cctgctgacc aaagagaaag  10020

cgaaagggat ccaggccaaa gttacagctg caaaagaaga ttggaaaaat tttcattcaa  10080

atctccacca aaaagaatct gctctagaga atctaaagat ccaaatgaag gactttgaag  10140

taagtgctga gcctatccag gactggctga gtaaaactga gaagatggtc catgaaagca  10200

gcaatcgcct ctatgatctg ccagcaaaga ggagggagca gcagaagctc cagtctgtcc  10260

ttgaggaaat acactgctac gagcctcagc tcaacaggct gaaagagaaa gctcagcagc  10320

tgtgggaagg acaagctgcc agcaagagct ttaggcacag agtgtcgcag ctgtcttctc  10380

agtatctagc gctaagcaat ttaacaaagg agaaagtgtc aagactggat agaatcgttg  10440

cagaacacaa tcagttctct cttgggatta aagaattaca agactggatg acggatgcga  10500

ttcacatgct ggattcatac tgccacccga catccgacaa aagtgtgctg gacagcagga  10560

cgctcaagct cgaggctcta ttatcagtca aacaggaaaa agagattcag atgaaaatga  10620

tagtgaccag gggagaatct gtccttcaga atacttctcc agaaggcatt cccactattc  10680

agcagcagct gcagagtgtg aaggatatgt gggcatccct tttgtctgca gggattcgtt  10740

gtaaaagcca actcgaagga gctctctcca agtggacaag ttatcaggat ggcgttcgac  10800

agttctccgg ttggatggat agtatggaag ccaacctgaa tgaatcagaa aggcagcatg  10860

cggagctgcg ggataaaaca acgatgctcg gaaaagccaa gttattaaat gaagaagtgc  10920

tgagttacag cagcttgctg gagaccatcg aagtcaaagg ggctggcatg acagaacact  10980

atgtcaccca gctagaactc caggatctac aggaacgata cagagccatc caagagaggg  11040

ccaaggaagc cgtaaccaag tctgaaaaac ttgtccgcct gcaccaagag tatcagagag  11100

acctaaaggc atttgaagtt tggttggggc aagaacaaga aaagctcgac cagtattcag  11160

ttcttgaagg tgatgcccac actcatgaga caacattgcg tgatcttcag gagctacagg  11220

tacactgtgc agaggggcag gccctgttga actcagtgct gcacaccaga gaggatgtga  11280

tcccatcagg tatcccacag gcagaggacc gggctttaga gtctctccgg caagactggc  11340

aggcttacca gcacaggctg tccgagactc gaactcagtt caataacgtg gtgaacaaat  11400

tgaggctaat ggagcaaaag tttcagcaag tagatgaatg gctcaaaaca gcagaggaga  11460

aagttagtcc caggaccaga cgtcagtcta acagggcaac caaggagata caattacatc  11520

agatgaagaa gtggcacgaa gaagtgactg catacagaga tgaagttgag gaagtgggag  11580

ctagagctca ggagatactg gacgagagcc acgtgaacag cagaatgggt tgccaggcca  11640

cccagctgac ttccagatac caggccctgc ttctccaagt gctggaacaa ataaaattcc  11700

tggaggagga gattcagagt ttggaggaat cagaatcatc cctcagttcc tattctgatt  11760

ggtatggctc tactcataaa aacttcaaga atgtggctac caagattgac aaagtagata  11820

cagtaatgat ggggaagaaa ttgaagacgt tggaggtttt gctcaaagac atggagaaag  11880

gtcacagttt gctgaaatca gcccgggaga aaggagagag ggctgttaaa tacttggagg  11940

aaggcgaggc agagaggtta agaaaggaga ttcatgatca catggagcag ttgaaggaac  12000

tgaccagcac tgtccggaaa gaacacatga cgctggaaaa aggtcttcat ttagcaaagg  12060

aattctcaga taaatgcaaa gcactgacac agtggatagc agaataccag gaaattctac  12120

atgttcctga agaacccaaa atggaattat atgagaaaaa agctcagtta tctaaataca  12180

agtcacttca acaaacggtg ctgtcccatg aaccatcagt aaagtcagtg agagagaagg  12240

gtgaagctct tttggaactg gtgcaggacg tcactttaaa ggacaaaata gatcaacttc  12300

aaagtgatta ccaggacctg tgcagcatag gaaaggagca tgtcttcagt ctggaggcga  12360

aagtcaaaga ccatgaagac tacaacagtg agctccaaga ggtcgaaaag tggctgctgc  12420

agatgtctgg cagactggtg gcacctgacc tcctggagac aagcagcctg gagacaatca  12480

cccagcaatt ggcccaccac aaggcaatga tggaagaaat tgctggtttt gaagaccgtt  12540

tgaacaatct tcaaatgaaa ggtgatactt tgattggcca atgtgcagac cacctgcaag  12600

cgaaacttaa acaaaacgtg catgctcatc tgcagggcac aaaggacagc tactcagcga  12660

tctgcagcac agctcagagg atgtaccaga gtttggaaca cgaacttcag aagcacgtca  12720

gccgacaaga caccctgcag cagtgccagg cctggctttc tgcagtccag ccggatttag  12780

agccaagtcc tcaaccacct cttagtaggg cagaagccat taagcaggtc aaacacttca  12840

gagctttgca agagcaggca aggacctacc tagatctcct ttgctccatg tgtgacctgt  12900

caaatgcttc ggtgaaaacc acagcaaaag acattcaaca aacagagcaa acgattgaac  12960

aaaagcttgt ccaggcccag aacttaactc agggctggga agagatcaag cacctgaagt  13020

ctgagctctg gatttacctg caagatgctg atcagcaact gcagaacatg aagaggaggc  13080

actctgagct ggagctgaac attgcacaga acatggtttc acaagttaag gattttgtta  13140

agaaactaca gagcaaacag gcatccgtga acaccataat agaaaaggtg aataagttaa  13200

caaagaagga ggaatcgcct gaacacaagg aaataaatca tttaaatgat cagtggctcg  13260

atttgtgccg tcagtctaac aacctgtgct tgcaaaggga agaggatctt cagagaacaa  13320

gagattacca tgactgtatg aatgttgttg aagtgttcct agaaaaattt actacagaat  13380

gggataactt ggccagatct gatgcagaga gtacagctgt ccacctggaa gctttgaaaa  13440

agttagcatt ggcattgcag gagagaaagt atgctattga agatctgaaa gatcaaaagc  13500

agaaaatgat agagcatctg aatttagatg acaaggagtt agtcaaagaa cagacgagtc  13560

atttagagca acgttggttt cagcttgagg acctcattaa aaggaaaatc caagtgtcag  13620

tcaccaactt ggaggagtta aatgtggtgc agtccagatt tcaggagcta atggagtggg  13680

cagaagagca acaacccaac atcgccgagg cccttaagca gagccctcct ccagatatgg  13740

ctcagaacct tctcatggat cacctggcca tctgcagtga actggaggcc aagcagatgc  13800

tcctgaaatc gcttataaag gacgcagaca gggtcatggc agatcttggt ctcaatgagc  13860

gacaggtcat ccagaaggct ctctctgatg cacaaagcca cgtgaattgt ctcagtgact  13920

tagtgggcca gcgaagaaag tacttaaaca aagccttgtc cgagaaaacc cagtttctca  13980

tggcagtgtt ccaggccacc agccaaattc agcaacatga gcgaaagata atgttccgtg  14040

aacacatctg tctgttacca gatgatgtga gcaaacaagt caaaacatgt aagagtgcac  14100

aagccagcct caagacttac caaaatgaag tcactggact ttgggcccag ggtcgcgaac  14160

taatgaagga agtcacagag caggaaaaga gtgaagtgct ggggaagctt caggaattgc  14220

agagtgtcta tgacagtgtt ttacaaaagt gcagtcaccg gttacaagaa ctagagaaga  14280

atttggtttc taggaagcat tttaaggaag attttgataa agcttgccac tggctaaaac  14340

aagcagatat tgttacattt cctgaaatca acctaatgaa tgagagttct gagcttcata  14400

cacaactggc taaataccaa aacattcttg aacaatctcc agaatatgaa aatcttctac  14460

ttacgctgca gagaactggg cagaccatat taccatcgct gaatgaagtc gatcattcct  14520

acctcagtga aaagctaaat gctttgcctc gacaatttaa tgtaattgtt gccttggcta  14580

aagacaagtt ctataaagtc caggaagcaa ttcttgctcg gaaggaatat gcttccttga  14640

ttgagttgac aacccagtct ctgagtgaac ttgaagccca attcttgagg atgagcaaag  14700

ttcccaccga cctggccgtt gaggaggctc tttctctgca agatggttgc agagccattc  14760

tggacgaggt ggcgggcctt ggggaggcgg tggatgaact gaaccagaaa aaagaaggtt  14820

ttcgcagcac aggtcagcct tggcagccag acaagatgct gcaccttgtc accttatatc  14880

acaggctgaa gcgacaaaca gaacagaggg ttagcttatt agaagacacc accagtgctt  14940

accaagaaca cgagaagatg tgccaacagc tggagagaca actgaagtct gtaaaagagg  15000

agcagtccaa agtgaatgag gaaacgctgc ctgcagagga gaagctcaaa atgtatcact  15060

ccctggcagg aagtctccag gactcaggga ttgtactgaa acgagtaacc atacatcttg  15120

aagatcttgc cccacacctt gaccccttgg cttatgagaa agccaggcat cagatccagt  15180

cctggcaagg ggagttaaaa ctgttgactt ctgccattgg tgagacggtg acagaatgtg  15240

agagccgaat ggtgcagagt atagacttcc agactgagat gagtcgctcc ctggactggc  15300

tgaggagagt gaaggcagag ctcagtgggc cggtgtacct agacctcaac ctgcaggaca  15360

tccaagagga aatcagaaaa atccaaattc atcaggaaga ggtccagtcc agcttgagaa  15420

tcatgaatgc gctgagtcac aaggaaaagg agaagttcac aaaggccaag gagctgattt  15480

ctgcggattt agaacacagc ctcgctgagc tctcagagct ggatggagac atccaggaag  15540

ccttacgcac cagacaggct accttgactg aaatatatag ccagtgtcaa aggtattatc  15600

aggtatttca agcagccaat gactggcttg aggatgccca agaattgtta cagctggcag  15660

gcaatggcct agacgtggag agcgcagagg aaaatctcaa aagccacatg gaatttttca  15720

gtacagagga tcagttccat agtaacctgg aggagctcca cagcctggta gccaccctgg  15780

acccactcat caagccaacc ggcaaagaag acctagaaca gaaagtggct tctctggaac  15840

tcaggagcca gaggatgagc cgggactctg gtgcccaagt ggatctcttg cagagatgca  15900

cagctcaatg gcacgattac cagaaagcaa gggaagaggt tattgaattg atgaatgata  15960

cagaaaagaa attgtctgag ttttctttgt tgaagacttc gtctagtcat gaagcggaag  16020

aaaaattgtc agaacacaag gctttagtgt cagtggttaa ctctttccat gagaaaattg  16080

tggcccttga ggaaaaagct tcacaactgg agaaaaccgg aaatgatgcc agcaaagcca  16140

ccctgagcag gtcaatgacc accgtctggc agcgctggac acgccttcga gctgtggccc  16200

aggaccagga gaagatcctg gaagatgcag tggatgagtg gacgggcttt aacaacaagg  16260

ttaaaaaggc cactgaaatg attgatcagc tgcaagataa gttacctgga agttcagcag  16320

agaaagcatc gaaagcagag ctcttaactc ttcttgaata ccacgacacg ttcgttctgg  16380

agctggagca gcagcagtcg gccttgggca tgctgcggca gcaaaccctg agcatgctcc  16440

aggatggagc cgccccaacc cctggggaag agcctccgct catgcaggaa atcaccgcca  16500

tgcaagatcg gtgcctgaac atgcaggaga aagtgaagac taatggaaag ttggtgaagc  16560

aagagctgaa ggaccgagaa atggtggaga ctcagatcaa ttctgtgaaa tgttgggttc  16620

aggaaacgaa agaatattta gggaatccaa caatagaaat agatgctcaa cttgaagaac  16680

ttcagattct cctaacagaa gccacaaatc accgacagaa cattgaaaaa atggcagaag  16740

aacagaagga gaagtactta ggtctttata ccatattacc ttctgaactc tcccttcagt  16800

tggctgaagt ggcgttagat ctaaagatcc gagatcagat ccaagacaaa ataaaagaag  16860

ttgagcagag caaggccacg agccaggaac tcagccggca aattcagaag ttagctaaag  16920

acctcacaac tattctaact aagctgaaag cgaagacaga taatgtagtt caagctaaaa  16980

ctgaccaaaa ggtgctggga gaggaattag atggctgtaa ttcaaagtta atggaattag  17040

atgcagcagt acagaaattc ttggaacaga atggccaact gggtaagcca ctggccaaga  17100

agataggaaa actgactgaa cttcaccagc agaccattag acaagctgag aatcggctct  17160

ccaagctcaa tcaggcagca tcacatttag aagaatacaa tgaaatgctt gaattaattt  17220

tgaagtggat tgaaaaagct aaagtcttgg ctcatggaac tattgcatgg aattctgcaa  17280

gccagcttcg ggaacaatat attttgcatc agaccctgct agaagaatcc aaagaaattg  17340

acagtgagct ggaagcaatg actgagaaat tacagtacct cactagcgtg tactgtacag  17400

aaaaaatgtc tcagcaagtg gcagaactgg gacgggagac tgaggagttg cgacagatga  17460

tcaaaattcg tttgcagaac ctccaagatg cagctaagga tatgaaaaaa tttgaagcag  17520

agttgaaaaa gttacaagct gccttggagc aagcccaggc aacactgact tctccagaag  17580

ttggacgtct cagtctcaag gagcagctct ctcatcggca gcatttgttg tctgagatgg  17640

agtcactgaa gccgaaggtg caagcagtgc agctctgcca gagtgccctc cggatccccg  17700

aggatgtggt tgccagctta cctctctgtc atgctgctct gcggctgcag gaagaggcca  17760

gccggctgca gcacaccgcc atccagcagt gtaacatcat gcaggcagct gtggtacaat  17820

atgaacaata tgagcaagaa atgaaacatc tccagcaact gatagaagga gctcacagag  17880

agattgagga taaacctgtt gccaccagta acatacagga gctgcaggct cagatttctc  17940

ggcatgagga gctggcgcag aaaattaagg gctaccagga gcagatcgct tctttgaatt  18000

ccaagtgcaa gatgctgacg atgaaagcca agcacgccac catgctgctg acggtgaccg  18060

aggtcgaggg gctggcggaa gggacagagg acctggatgg ggagctcctc cccacgcctt  18120

cggcccaccc ctctgtggtc atgatgactg caggtcgctg tcacactttg ctgtcaccgg  18180

tcactgagga gtctggggag gagggaacca acagtgagat ttcctctcca cctgcctgtc  18240

gctccccttc acctgtggct aatacagatg cttctgttaa ccaggacatt gcatattacc  18300

aagccttgtc tgctgagagg ttgcagacag atgctgcaaa aattcacccc agcacatccg  18360

catcccagga gttctatgaa ccgggattgg agccatccgc tactgccaaa ctgggtgatt  18420

tgcagcgttc ttgggaaacc ttaaagaatg tgatcagtga gaagcagcgc acactctatg  18480

aagctttgga acgccagcag aagtaccagg actccctcca gtccatctct acgaagatgg  18540

aggccattga gctgaaactc agtgagagcc cagagcctgg caggagtcca gaaagccaga  18600

tggctgaaca tcaggcattg atggatgaga ttctcatgct ccaggatgaa atcaatgagc  18660

tccagtcctc tctcgcagag gagctggtat ccgagtcttg tgaggccgac cctgcggagc  18720

agctggcctt gcagtccacg ctcactgtct tagccgagcg aatgtccacc atcaggatga  18780

aagcctcggg gaaacggcag cttttggagg agaagttgaa tgatcagctg gaggaacaaa  18840

ggcaggaaca ggccctgcag aggtatcgct gtgaagccga tgagctggac agctggctct  18900

tgagtaccaa ggccactctg gacactgcgc tgagtccacc caaggagccc atggacatgg  18960

aggcccagct tatggactgc cagaatatgc tggtggaaat agagcagaag gtggtggctt  19020

tatcagaact gtcagtccac aatgagaacc tgctgctgga gggcaaagct cacaccaagg  19080

acgaggccga gcagctggct ggaaagctga gaaggctcaa ggggagcctg ctggagctgc  19140

agagagccct gcatgataag cagctcaaca tgcagggaac agcacaggag aaggaggaga  19200

gcgatgttga cctaacagcc acgcagagcc ccggcgtcca ggaatggctg gcccaagctc  19260

gcaccacatg gacccagcag cggcagagca gtctccagca acaaaaagag ttagaacagg  19320

aattagccga gcagaagagt ctccttcgct cagtagccag tcgtggagag gagattctaa  19380

ttcaacattc ggcggcagag acctctggtg atgctggcga aaaacctgat gtgttatccc  19440

aggagttggg gatggaaggg gagaaatcat ccgctgaaga ccagatgaga atgaaatggg  19500

aaagcctaca tcaagaattt agtaccaagc agaaactact acagaatgtt ctggaacagg  19560

aacaagagca agtgctttat agcaggccaa atcgactctt gtctggtgtg ccactgtaca  19620

aaggggacgt gccaacccaa gataaatctg cagttacatc tttgctggat ggactgaacc  19680

aagccttcga ggaggtttca tcccagagtg gaggggcaaa gaggcagagt atacacttgg  19740

agcagaagtt gtatgatgga gtctcagcca cctctacttg gttggatgac gttgaagaac  19800

gtttatttgt tgccacagca cttttaccag aagaaacaga gacttgtctc ttcaaccaag  19860

agattcttgc caaagacatt aaggaaatgt ctgaagaaat ggataagaac aaaaacttgt  19920

tttcccaagc ttttccagag aatggtgata atcgagatgt tattgaagat actttgggtt  19980

gtcttttggg caggttatcc ttgctagact cagtagtgaa tcaacgatgt catcagatga  20040

aagaaagact tcagcaaata ctaaatttcc agaatgatct gaaagtgctg tttacatcac  20100

tggctgacaa caaatacatc attctgcaaa aactggcaaa tgtgtttgaa cagcccgtag  20160

cagaacaaat agaggcaata caacaggctg aagatggact caaagaattt gatgcaggaa  20220

tcattgaatt aaagaggcgt ggtgacaagc tacaggtcga gcagccgtcc atgcaagaac  20280

tctccaagct ccaggacatg tatgatgagc tgatgatgat cattggctcc cggaggagtg  20340

gtctgaatca gaaccttaca ctcaagagtc agtatgagag ggccctacaa gatctggctg  20400

acctgctaga aactggtcag gagaagatgg caggagacca gaaaatcatc gtgtcttcca  20460

aagaggaaat ccagcaacta cttgacaaac ataaggaata ctttcagggc ctggaatctc  20520

atatgatctt gactgaaaca ctcttcagaa agataatcag ctttgcagtc caaaaggaaa  20580

cccagttcca tacagagctg atggctcagg cttctgctgt actgaaacgg gctcacaaga  20640

ggggtgtgga gctggagtac attctagaga cgtggtccca tctggatgag gaccagcagg  20700

agctcagcag acagctggag gtggtggaaa gcagcatccc aagcgtgggt ctggtggagg  20760

agaacgagga caggcttatt gaccgcataa cactctacca gcatttaaaa tctagcctta  20820

atgaatacca gcccaaatta tatcaagtat tagatgatgg gaaacgactt ctgatatcca  20880

tcagctgctc agatctagaa agccaactaa atcaacttgg agagtgctgg ctaagtaaca  20940

ccaataaaat gtctaaggaa cttcacagac tggaaacaat attgaaacac tggaccagat  21000

atcaaagtga atctgcagat ctaattcact ggttacaatc tgcaaaagac cggctagaat  21060

tttggactca gcaatctgtg acagtcccac aagagctgga aatggtccgt gatcatctaa  21120

atgctttcct ggagttttct aaagaagtgg atgcccaatc ttccctgaaa tcatctgttc  21180

tgagtactgg aaatcagctc cttcgactaa aaaaggtgga cacagccacg ctgcgctctg  21240

agctgtcgcg cattgatagc cagtggactg acctgctaac caatatccca gccgtccagg  21300

agaagctcca ccagctccag atggataaac tgccttcccg ccatgccatt tctgaagtca  21360

tgagttggat ttctctaatg gaaaatgtta ttcagaagga tgaagataat attaaaaatt  21420

ccataggtta caaggcaatt catgaatacc ttcagaaata taagggtttt aagatagaca  21480

ttaactgtaa acagctgaca gtggattttg tgaaccagtc cgtgctacaa atcagcagtc  21540

aggatgtgga aagtaagcgt agtgataaga ctgattttgc tgagcaactt ggagcaatga  21600

ataaaagttg gcaaattctg caaggtctag taactgagaa gatccagctg ttggaaggct  21660

tattggaatc ttggtcagaa tatgaaaata atgtacaatg tctgaaaaca tggtttgaaa  21720

cccaggaaaa gagactaaaa caacagcatc gaattggaga tcaggcttct gttcaaaatg  21780

cactgaaaga ctgtcaggat ctggaagatt tgattaaagc aaaagaaaaa gaagtagaga  21840

aaattgagca gaatggactt gctttgattc agaacaagaa agaagacgtc tctagcattg  21900

tcatgagcac actgcgagag ctcggccaaa cctgggcaaa tttagatcac atggttggac  21960

aattaaagat actgctgaaa tcagtgcttg accaatggag tagtcacaaa gtggcctttg  22020

acaagataaa cagttacctc atggaggcca gatactctct ttcccgattc cgtctgctga  22080

ctggctcctt agaagctgtg caagttcagg tggacaatct tcagaatctc caagatgatc  22140

tggaaaaaca ggaaaggagc ttacagaaat ttggctctat caccaaccaa ttattaaaag  22200

agtgtcaccc acccgtgaca gaaactctta ccaatacact gaaagaagtc aacatgagat  22260

ggaataactt gctggaagag attgctgagc agctacagtc cagcaaggcc ctacttcagc  22320

tttggcaaag atacaaggac tactccaaac agtgtgcttc gacagttcag cagcaggagg  22380

atcgaaccaa tgagctgttg aaggcagcca caaacaagga cattgccgat gatgaggttg  22440

ccacatggat tcaagattgc aacgacctcc tcaaaggact gggcacagtt aaagattccc  22500

tcttttttct ccatgagctg ggagagcaac tgaagcaaca agtggatgct tccgcagcat  22560

cagctattca atcggatcaa ctctctttga gtcaacactt gtgtgccctg gagcaagctc  22620

tctgcaaaca gcagacttca ttacaggctg gagttcttga ttatgaaacc tttgccaaga  22680

gtttagaagc tttggaggcc tggatagtgg aagctgaaga aatactacaa gggcaggacc  22740

ctagccactc atctgacctc tccacaatcc aggaaaggat ggaagaactt aagggacaga  22800

tgttaaaatt cagcagcatg gctccagatt tagaccgtct aaatgagctt ggatataggt  22860

tacccttgaa tgataaggaa atcaaaagaa tgcagaatct gaaccgccat tggtctctga  22920

tctcctctca gactacagaa agattcagca agttgcagtc atttttgcta caacatcaga  22980

ctttcttgga aaaatgtgaa acatggatgg aattcctagt tcagacagaa caaaagttag  23040

cagtagagat ttcaggaaat tatcagcacc ttttggaaca gcagagagca cacgagttgt  23100

ttcaagccga gatgttcagt cgtcagcaga ttttgcactc aatcattatt gatgggcaac  23160

gtcttctaga acaaggtcaa gttgatgaca gggatgaatt caacctgaaa ttgacactcc  23220

tcagtaatca atggcaggga gtgattcgca gggcccagca gaggcggggg atcattgaca  23280

gccagattcg ccagtggcag cgctataggg agatggcaga aaagcttcgt aaatggttgg  23340

ttgaagtgtc ctacctcccc atgagtggtc tcggaagtgt tcctatacca ctgcaacaag  23400

caaggaccct ctttgatgaa gtgcagttca aagaaaaagt gtttctgcgg caacaaggca  23460

gctacatcct gactgtggag gctggcaagc aactccttct ctcggcggac agtggcgctg  23520

aggccgcctt gcaggccgaa ctcgctgaaa tccaagagaa atggaaatca gccagcatgc  23580

ggctggaaga acagaagaaa aaactagcct tcttgttgaa agactgggaa aaatgtgaga  23640

aaggaatagc agattccctg gagaaactac gaactttcaa aaagaagctt tcgcagtctc  23700

tcccggatca ccatgaagag ctccatgcag aacaaatgcg ttgcaaggaa ttagaaaatg  23760

cagttgggag ctggacagat gacttgaccc agttgagcct gctgaaggac accctctctg  23820

cctatatcag tgctgatgat atctccattc ttaatgaacg cgtagagctt ctgcaaaggc  23880

agtgggaaga actatgccac cagctctcct taaggcggca gcaaataggt gaaagattga  23940

atgaatgggc agtcttcagt gaaaagaaca aggaactctg tgagtggttg actcaaatgg  24000

aaagcaaagt ttctcagaat ggagacattc tcattgaaga aatgatagag aagctcaaga  24060

aggattatca agaggaaatt gctattgctc aagagaacaa aatacagctc caacaaatgg  24120

gagaacgact tgctaaagcc agccatgaaa gcaaagcatc tgagattgaa tacaagctgg  24180

gaaaggtcaa cgaccggtgg cagcatctcc tggacctcat tgcagccagg gtgaagaagc  24240

tgaaggagac cctggtagcc gtgcagcagc ttgataagaa catgagcagc ctgaggacct  24300

ggctcgctca catcgagtca gagctggcca agccaatagt ctacgattcc tgtaactcgg  24360

aagaaataca gagaaagctt aatgagcagc aggagcttca gagagacata gagaagcaca  24420

gtacaggtgt tgcatctgtc ctcaacctgt gtgaagtcct gctgcacgac tgtgacgcct  24480

gtgccactga tgccgagtgt gactctatac agcaggctac gagaaacctg gaccggcggt  24540

ggagaaacat ttgtgctatg tccatggaaa ggaggctgaa aatcgaagag acgtggcgat  24600

tgtggcagaa atttctggat gactattcac gttttgaaga ttggctgaag tcttcagaaa  24660

ggacagctgc ttttcccagc tcttctgggg tgatctatac agttgccaag gaagaactaa  24720

agaaatttga ggctttccag cgacaggtcc acgagtgcct gacgcagctg gaactgatca  24780

acaagcagta ccgccgcctg gccagggaga accgcactga ttcagcatgt agcctcaaac  24840

agatggttca cgaaggcaac cagagatggg acaacctgca aaagcgtgtc acctccatct  24900

tgcgcagact caagcatttt attggccagc gtgaggagtt tgagactgcg cgggacagca  24960

ttctggtctg gctcacagag atggatctgc agctcactaa tattgaacat ttttctgagt  25020

gtgatgttca agctaaaata aagcaactca aggccttcca gcaggaaatt tcactgaacc  25080

acaataagat tgagcagata attgcccaag gagaacagct gatagaaaag agtgagccct  25140

tggatgcagc gatcatcgag gaggaactag atgagctccg acggtactgc caggaggtct  25200

tcgggcgtgt ggaaagatac cataagaaac tgatccgcct gcctctccca gacgatgagc  25260

acgacctctc agacagggag ctggagctgg aagactctgc agctctgtcg gacctgcact  25320

ggcacgaccg ctctgcagac agcctgcttt ctccacagcc ttcctccaat ctctccctct  25380

cgctcgctca gcccctccgg agcgagcggt caggacgaga caccccggct agtgtggact  25440

ccatccccct ggagtgggat cacgactatg acctcagtcg ggacctggag tctgcaatgt  25500

ccagagctct gccctctgag gatgaagaag gtcaggatga caaagatttc tacctccggg  25560

gagctgttgg cttatcaggg gaccacagtg ccctagagtc acagatccga caactgggca  25620

aagccctgga tgatagccgt tttcagatac agcaaaccga aaatatcatt cgcagcaaaa  25680

ctcccacggg gccggagcta gacaccagct acaaaggcta catgaaactg ctgggcgaat  25740

gcagtagcag tatagactcc gtgaagagac tggagcacaa actgaaggag gaagaggaga  25800

gccttcctgg ctttgttaac ctgcatagta ccgaaaccca aacggctggt gtgattgacc  25860

gatgggagct tctccaggcc caggcattga gcaaggagtt gaggatgaag cagaacctcc  25920

agaagtggca gcagtttaac tcagacttga acagcatctg ggcctggctg ggggacacgg  25980

aggaggagtt ggaacagctc cagcgtctgg aactcagcac tgacatccag accatcgagc  26040

tccagatcaa aaagctcaag gagctccaga aagctgtgga ccaccgcaaa gccatcatcc  26100

tctccatcaa tctctgcagc cctgagttca cccaggctga cagcaaggag agccgggacc  26160

tgcaggatcg cttgtcgcag atgaatgggc gctgggaccg agtgtgctct ctgctggagg  26220

agtggcgggg cctgctgcag gatgccctga tgcagtgcca gggtttccat gaaatgagcc  26280

atggtttgct tcttatgctg gagaacattg acagaaggaa aaatgaaatt gtccctattg  26340

attctaacct tgatgcagag atacttcagg accatcacaa acagcttatg caaataaagc  26400

atgagctgtt ggaatcccaa ctcagagtag cctctttgca agacatgtct tgccaactac  26460

tggtgaatgc tgaaggaaca gactgtttag aagccaaaga aaaagtccat gttattggaa  26520

atcggctcaa acttctcttg aaggaggtca gtcgtcatat caaggaactg gagaagttat  26580

tagacgtgtc aagtagtcag caggatttgt cttcctggtc ttctgctgat gaactggaca  26640

cctcagggtc tgtgagtccc acatcaggaa ggagcacccc aaacagacag aaaacgccac  26700

gaggcaagtg tagtctctca cagcctggac cctctgtcag cagtccacat agcaggtcca  26760

caaaaggtgg ctccgattcc tccctttctg agccagggcc aggtcggtcc ggccgcggct  26820

tcctgttcag agtcctccga gcagctcttc cccttcagct tctcctgctc ctcctcatcg  26880

ggcttgcctg ccttgtacca atgtcagagg aagactacag ctgtgccctc tccaacaact  26940

ttgcccggtc attccacccc atgctcagat acacgaatgg ccctcctcca ctctgaacta  27000

agcagatgcc atctgcagaa gtgctggtag cataaggagg atcgggtcat aagcaatccc  27060

aaactaccaa caagaggacc ttgatcttgg cgaaagccct cggtgtggca gctttagccc  27120

tcctccagat cacatgtgtg caaattatgg cttcagaggt ggaagataaa cagtgacggg  27180

ggaacaaaca gacaacaaga aggtttggaa gaaatctggt ttgagactct gaaccttagc  27240

actaaggaga ttgagtaagg acctccaaag ttccccggac tcatgaattc tgggcccttg  27300

gcccattctg tgcacagcca aggacttcag tagaccatct gggcagcttt cccatggtgc  27360

tgctccaacc atcagataaa tgaccctccc aagcaccatg tcagtgtcgt acaatctacc  27420

aaccaaccag tgctgaagag attttagaac cttgtaacat acaattttta agagcttata  27480

tggcagcttc ctttttacct tgttttcctt tggggcatga tgttttaacc tttgctttag  27540

aagcacaagc tgtaaatcta aaaggcactt ttttttagag gtataaagaa aaactagatg  27600

taataaataa gatcatggaa ggctttatgt gaaaaaagtt gaatgttata gtaaaaaaaa  27660

aaagatattt atgtatgtac agtttgctaa agccaagttt tgtttgtatt gatttctttg  27720

catttattat agatattata aaata                                        27745


<210>  391
<211>  8797
<212>  PRT
<213>  Homo sapiens

<400>  391

Met Ala Thr Ser Arg Gly Ala Ser Arg Cys Pro Arg Asp Ile Ala Asn 
1               5                   10                  15


Val Met Gln Arg Leu Gln Asp Glu Gln Glu Ile Val Gln Lys Arg Thr 
            20                  25                  30


Phe Thr Lys Trp Ile Asn Ser His Leu Ala Lys Arg Lys Pro Pro Met 
        35                  40                  45


Val Val Asp Asp Leu Phe Glu Asp Met Lys Asp Gly Val Lys Leu Leu 
    50                  55                  60


Ala Leu Leu Glu Val Leu Ser Gly Gln Lys Leu Pro Cys Glu Gln Gly 
65                  70                  75                  80


Arg Arg Met Lys Arg Ile His Ala Val Ala Asn Ile Gly Thr Ala Leu 
                85                  90                  95


Lys Phe Leu Glu Gly Arg Lys Ile Lys Leu Val Asn Ile Asn Ser Thr 
            100                 105                 110


Asp Ile Ala Asp Gly Arg Pro Ser Ile Val Leu Gly Leu Met Trp Thr 
        115                 120                 125


Ile Ile Leu Tyr Phe Gln Ile Glu Glu Leu Thr Ser Asn Leu Pro Gln 
    130                 135                 140


Leu Gln Ser Leu Ser Ser Ser Ala Ser Ser Val Asp Ser Ile Val Ser 
145                 150                 155                 160


Ser Glu Thr Pro Ser Pro Pro Ser Lys Arg Lys Val Thr Thr Lys Ile 
                165                 170                 175


Gln Gly Asn Ala Lys Lys Ala Leu Leu Lys Trp Val Gln Tyr Thr Ala 
            180                 185                 190


Gly Lys Gln Thr Gly Ile Glu Val Lys Asp Phe Gly Lys Ser Trp Arg 
        195                 200                 205


Ser Gly Val Ala Phe His Ser Val Ile His Ala Ile Arg Pro Glu Leu 
    210                 215                 220


Val Asp Leu Glu Thr Val Lys Gly Arg Ser Asn Arg Glu Asn Leu Glu 
225                 230                 235                 240


Asp Ala Phe Thr Ile Ala Glu Thr Glu Leu Gly Ile Pro Arg Leu Leu 
                245                 250                 255


Asp Pro Glu Asp Val Asp Val Asp Lys Pro Asp Glu Lys Ser Ile Met 
            260                 265                 270


Thr Tyr Val Ala Gln Phe Leu Lys His Tyr Pro Asp Ile His Asn Ala 
        275                 280                 285


Ser Thr Asp Gly Gln Glu Asp Asp Glu Ile Leu Pro Gly Phe Pro Ser 
    290                 295                 300


Phe Ala Asn Ser Val Gln Asn Phe Lys Arg Glu Asp Arg Val Ile Phe 
305                 310                 315                 320


Lys Glu Met Lys Val Trp Ile Glu Gln Phe Glu Arg Asp Leu Thr Arg 
                325                 330                 335


Ala Gln Met Val Glu Ser Asn Leu Gln Asp Lys Tyr Gln Ser Phe Lys 
            340                 345                 350


His Phe Arg Val Gln Tyr Glu Met Lys Arg Lys Gln Ile Glu His Leu 
        355                 360                 365


Ile Gln Pro Leu His Arg Asp Gly Lys Leu Ser Leu Asp Gln Ala Leu 
    370                 375                 380


Val Lys Gln Ser Trp Asp Arg Val Thr Ser Arg Leu Phe Asp Trp His 
385                 390                 395                 400


Ile Gln Leu Asp Lys Ser Leu Pro Ala Pro Leu Gly Thr Ile Gly Ala 
                405                 410                 415


Trp Leu Tyr Arg Ala Glu Val Ala Leu Arg Glu Glu Ile Thr Val Gln 
            420                 425                 430


Gln Val His Glu Glu Thr Ala Asn Thr Ile Gln Arg Lys Leu Glu Gln 
        435                 440                 445


His Lys Asp Leu Leu Gln Asn Thr Asp Ala His Lys Arg Ala Phe His 
    450                 455                 460


Glu Ile Tyr Arg Thr Arg Ser Val Asn Gly Ile Pro Val Pro Pro Asp 
465                 470                 475                 480


Gln Leu Glu Asp Met Ala Glu Arg Phe His Phe Val Ser Ser Thr Ser 
                485                 490                 495


Glu Leu His Leu Met Lys Met Glu Phe Leu Glu Leu Lys Tyr Arg Leu 
            500                 505                 510


Leu Ser Leu Leu Val Leu Ala Glu Ser Lys Leu Lys Ser Trp Ile Ile 
        515                 520                 525


Lys Tyr Gly Arg Arg Glu Ser Val Glu Gln Leu Leu Gln Asn Tyr Val 
    530                 535                 540


Ser Phe Ile Glu Asn Ser Lys Phe Phe Glu Gln Tyr Glu Val Thr Tyr 
545                 550                 555                 560


Gln Ile Leu Lys Gln Thr Ala Glu Met Tyr Val Lys Ala Asp Gly Ser 
                565                 570                 575


Val Glu Glu Ala Glu Asn Val Met Lys Phe Met Asn Glu Thr Thr Ala 
            580                 585                 590


Gln Trp Arg Asn Leu Ser Val Glu Val Arg Ser Val Arg Ser Met Leu 
        595                 600                 605


Glu Glu Val Ile Ser Asn Trp Asp Arg Tyr Gly Asn Thr Val Ala Ser 
    610                 615                 620


Leu Gln Ala Trp Leu Glu Asp Ala Glu Lys Met Leu Asn Gln Ser Glu 
625                 630                 635                 640


Asn Ala Lys Lys Asp Phe Phe Arg Asn Leu Pro His Trp Ile Gln Gln 
                645                 650                 655


His Thr Ala Met Asn Asp Ala Gly Asn Phe Leu Ile Glu Thr Cys Asp 
            660                 665                 670


Glu Met Val Ser Arg Asp Leu Lys Gln Gln Leu Leu Leu Leu Asn Gly 
        675                 680                 685


Arg Trp Arg Glu Leu Phe Met Glu Val Lys Gln Tyr Ala Gln Ala Asp 
    690                 695                 700


Glu Met Asp Arg Met Lys Lys Glu Tyr Thr Asp Cys Val Val Thr Leu 
705                 710                 715                 720


Ser Ala Phe Ala Thr Glu Ala His Lys Lys Leu Ser Glu Pro Leu Glu 
                725                 730                 735


Val Ser Phe Met Asn Val Lys Leu Leu Ile Gln Asp Leu Glu Asp Ile 
            740                 745                 750


Glu Gln Arg Val Pro Val Met Asp Ala Gln Tyr Lys Ile Ile Thr Lys 
        755                 760                 765


Thr Ala His Leu Ile Thr Lys Glu Ser Pro Gln Glu Glu Gly Lys Glu 
    770                 775                 780


Met Phe Ala Thr Met Ser Lys Leu Lys Glu Gln Leu Thr Lys Val Lys 
785                 790                 795                 800


Glu Cys Tyr Ser Pro Leu Leu Tyr Glu Ser Gln Gln Leu Leu Ile Pro 
                805                 810                 815


Leu Glu Glu Leu Glu Lys Gln Met Thr Ser Phe Tyr Asp Ser Leu Gly 
            820                 825                 830


Lys Ile Asn Glu Ile Ile Thr Val Leu Glu Arg Glu Ala Gln Ser Ser 
        835                 840                 845


Ala Leu Phe Lys Gln Lys His Gln Glu Leu Leu Ala Cys Gln Glu Asn 
    850                 855                 860


Cys Lys Lys Thr Leu Thr Leu Ile Glu Lys Gly Ser Gln Ser Val Gln 
865                 870                 875                 880


Lys Phe Val Thr Leu Ser Asn Val Leu Lys His Phe Asp Gln Thr Arg 
                885                 890                 895


Leu Gln Arg Gln Ile Ala Asp Ile His Val Ala Phe Gln Ser Met Val 
            900                 905                 910


Lys Lys Thr Gly Asp Trp Lys Lys His Val Glu Thr Asn Ser Arg Leu 
        915                 920                 925


Met Lys Lys Phe Glu Glu Ser Arg Ala Glu Leu Glu Lys Val Leu Arg 
    930                 935                 940


Ile Ala Gln Glu Gly Leu Glu Glu Lys Gly Asp Pro Glu Glu Leu Leu 
945                 950                 955                 960


Arg Arg His Thr Glu Phe Phe Ser Gln Leu Asp Gln Arg Val Leu Asn 
                965                 970                 975


Ala Phe Leu Lys Ala Cys Asp Glu Leu Thr Asp Ile Leu Pro Glu Gln 
            980                 985                 990


Glu Gln Gln Gly Leu Gln Glu Ala Val Arg Lys Leu His Lys Gln Trp 
        995                 1000                1005


Lys Asp Leu Gln Gly Glu Ala Pro Tyr His Leu Leu His Leu Lys Ile 
    1010                1015                1020


Asp Val Glu Lys Asn Arg Phe Leu Ala Ser Val Glu Glu Cys Arg Thr 
1025                1030                1035                1040


Glu Leu Asp Arg Glu Thr Lys Leu Met Pro Gln Glu Gly Ser Glu Lys 
                1045                1050                1055


Ile Ile Lys Glu His Arg Val Phe Phe Ser Asp Lys Gly Pro His His 
            1060                1065                1070


Leu Cys Glu Lys Arg Leu Gln Leu Ile Glu Glu Leu Cys Val Lys Leu 
        1075                1080                1085


Pro Val Arg Asp Pro Val Arg Asp Thr Pro Gly Thr Cys His Val Thr 
    1090                1095                1100


Leu Lys Glu Leu Arg Ala Ala Ile Asp Ser Thr Tyr Arg Lys Leu Met 
1105                1110                1115                1120


Glu Asp Pro Asp Lys Trp Lys Asp Tyr Thr Ser Arg Phe Ser Glu Phe 
                1125                1130                1135


Ser Ser Trp Ile Ser Thr Asn Glu Thr Gln Leu Lys Gly Ile Lys Gly 
            1140                1145                1150


Glu Ala Ile Asp Thr Ala Asn His Gly Glu Val Lys Arg Ala Val Glu 
        1155                1160                1165


Glu Ile Arg Asn Gly Val Thr Lys Arg Gly Glu Thr Leu Ser Trp Leu 
    1170                1175                1180


Lys Ser Arg Leu Lys Val Leu Thr Glu Val Ser Ser Glu Asn Glu Ala 
1185                1190                1195                1200


Gln Lys Gln Gly Asp Glu Leu Ala Lys Leu Ser Ser Ser Phe Lys Ala 
                1205                1210                1215


Leu Val Thr Leu Leu Ser Glu Val Glu Lys Met Leu Ser Asn Phe Gly 
            1220                1225                1230


Asp Cys Val Gln Tyr Lys Glu Ile Val Lys Asn Ser Leu Glu Glu Leu 
        1235                1240                1245


Ile Ser Gly Ser Lys Glu Val Gln Glu Gln Ala Glu Lys Ile Leu Asp 
    1250                1255                1260


Thr Glu Asn Leu Phe Glu Ala Gln Gln Leu Leu Leu His His Gln Gln 
1265                1270                1275                1280


Lys Thr Lys Arg Ile Ser Ala Lys Lys Arg Asp Val Gln Gln Gln Ile 
                1285                1290                1295


Ala Gln Ala Gln Gln Gly Glu Gly Gly Leu Pro Asp Arg Gly His Glu 
            1300                1305                1310


Glu Leu Arg Lys Leu Glu Ser Thr Leu Asp Gly Leu Glu Arg Ser Arg 
        1315                1320                1325


Glu Arg Gln Glu Arg Arg Ile Gln Val Thr Leu Arg Lys Trp Glu Arg 
    1330                1335                1340


Phe Glu Thr Asn Lys Glu Thr Val Val Arg Tyr Leu Phe Gln Thr Gly 
1345                1350                1355                1360


Ser Ser His Glu Arg Phe Leu Ser Phe Ser Ser Leu Glu Ser Leu Ser 
                1365                1370                1375


Ser Glu Leu Glu Gln Thr Lys Glu Phe Ser Lys Arg Thr Glu Ser Ile 
            1380                1385                1390


Ala Val Gln Ala Glu Asn Leu Val Lys Glu Ala Ser Glu Ile Pro Leu 
        1395                1400                1405


Gly Pro Gln Asn Lys Gln Leu Leu Gln Gln Gln Ala Lys Ser Ile Lys 
    1410                1415                1420


Glu Gln Val Lys Lys Leu Glu Asp Thr Leu Glu Glu Asp Ile Lys Thr 
1425                1430                1435                1440


Met Glu Met Val Lys Thr Lys Trp Asp His Phe Gly Ser Asn Phe Glu 
                1445                1450                1455


Thr Leu Ser Val Trp Ile Thr Glu Lys Glu Lys Glu Leu Asn Ala Leu 
            1460                1465                1470


Glu Thr Ser Ser Ser Ala Met Asp Met Gln Ile Ser Gln Ile Lys Val 
        1475                1480                1485


Thr Ile Gln Glu Ile Glu Ser Lys Leu Ser Ser Ile Val Gly Leu Glu 
    1490                1495                1500


Glu Glu Ala Gln Ser Phe Ala Gln Phe Val Thr Thr Gly Glu Ser Ala 
1505                1510                1515                1520


Arg Ile Lys Ala Lys Leu Thr Gln Ile Arg Arg Tyr Gly Glu Glu Leu 
                1525                1530                1535


Arg Glu His Ala Gln Cys Leu Glu Gly Thr Ile Leu Gly His Leu Ser 
            1540                1545                1550


Gln Gln Gln Lys Phe Glu Glu Asn Leu Arg Lys Ile Gln Gln Ser Val 
        1555                1560                1565


Ser Glu Phe Glu Asp Lys Leu Ala Val Pro Ile Lys Ile Cys Ser Ser 
    1570                1575                1580


Ala Thr Glu Thr Tyr Lys Val Leu Gln Glu His Met Asp Leu Cys Gln 
1585                1590                1595                1600


Ala Leu Glu Ser Leu Ser Ser Ala Ile Thr Ala Phe Ser Ala Ser Ala 
                1605                1610                1615


Arg Lys Val Val Asn Arg Asp Ser Cys Val Gln Glu Ala Ala Ala Leu 
            1620                1625                1630


Gln Gln Gln Tyr Glu Asp Ile Leu Arg Arg Ala Lys Glu Arg Gln Thr 
        1635                1640                1645


Ala Leu Glu Asn Leu Leu Ala His Trp Gln Arg Leu Glu Lys Glu Leu 
    1650                1655                1660


Ser Ser Phe Leu Thr Trp Leu Glu Arg Gly Glu Ala Lys Ala Ser Ser 
1665                1670                1675                1680


Pro Glu Met Asp Ile Ser Ala Asp Arg Val Lys Val Glu Gly Glu Leu 
                1685                1690                1695


Gln Leu Ile Gln Ala Leu Gln Asn Glu Val Val Ser Gln Ala Ser Phe 
            1700                1705                1710


Tyr Ser Lys Leu Leu Gln Leu Lys Glu Ser Leu Phe Ser Val Ala Ser 
        1715                1720                1725


Lys Asp Asp Val Lys Met Met Lys Leu His Leu Glu Gln Leu Asp Glu 
    1730                1735                1740


Arg Trp Arg Asp Leu Pro Gln Ile Ile Asn Lys Arg Ile Asn Phe Leu 
1745                1750                1755                1760


Gln Ser Val Val Ala Glu His Gln Gln Phe Asp Glu Leu Leu Leu Ser 
                1765                1770                1775


Phe Ser Val Trp Ile Lys Leu Phe Leu Ser Glu Leu Gln Thr Thr Ser 
            1780                1785                1790


Glu Ile Ser Ile Met Asp His Gln Val Ala Leu Thr Arg His Lys Asp 
        1795                1800                1805


His Ala Ala Glu Val Glu Ser Lys Lys Gly Glu Leu Gln Ser Leu Gln 
    1810                1815                1820


Gly His Leu Ala Lys Leu Gly Ser Leu Gly Arg Ala Glu Asp Leu His 
1825                1830                1835                1840


Leu Leu Gln Gly Lys Ala Glu Asp Cys Phe Gln Leu Phe Glu Glu Ala 
                1845                1850                1855


Ser Gln Val Val Glu Arg Arg Gln Leu Ala Leu Ser His Leu Ala Glu 
            1860                1865                1870


Phe Leu Gln Ser His Ala Ser Leu Ser Gly Ile Leu Arg Gln Leu Arg 
        1875                1880                1885


Gln Thr Val Glu Ala Thr Asn Ser Met Asn Lys Asn Glu Ser Asp Leu 
    1890                1895                1900


Ile Glu Lys Asp Leu Asn Asp Ala Leu Gln Asn Ala Lys Ala Leu Glu 
1905                1910                1915                1920


Ser Ala Ala Val Ser Leu Asp Gly Ile Leu Ser Lys Ala Gln Tyr His 
                1925                1930                1935


Leu Lys Ile Gly Ser Ser Glu Gln Arg Thr Ser Cys Arg Ala Thr Ala 
            1940                1945                1950


Asp Gln Leu Cys Gly Glu Val Glu Arg Ile Gln Asn Leu Leu Gly Thr 
        1955                1960                1965


Lys Gln Ser Glu Ala Asp Ala Leu Ala Val Leu Lys Lys Ala Phe Gln 
    1970                1975                1980


Asp Gln Lys Glu Glu Leu Leu Lys Ser Ile Glu Asp Ile Glu Glu Arg 
1985                1990                1995                2000


Thr Asp Lys Glu Arg Leu Lys Glu Pro Thr Arg Gln Ala Leu Gln Gln 
                2005                2010                2015


Arg Leu Arg Val Phe Asn Gln Leu Glu Asp Glu Leu Asn Ser His Glu 
            2020                2025                2030


His Glu Leu Cys Trp Leu Lys Asp Lys Ala Lys Gln Ile Ala Gln Lys 
        2035                2040                2045


Asp Val Ala Phe Ala Pro Glu Val Asp Arg Glu Ile Asn Arg Leu Glu 
    2050                2055                2060


Val Thr Trp Asp Asp Thr Lys Arg Leu Ile His Glu Asn Gln Gly Gln 
2065                2070                2075                2080


Cys Cys Gly Leu Ile Asp Leu Met Arg Glu Tyr Gln Asn Leu Lys Ser 
                2085                2090                2095


Ala Val Ser Lys Val Leu Glu Asn Ala Ser Ser Val Ile Val Thr Arg 
            2100                2105                2110


Thr Thr Ile Lys Asp Gln Glu Asp Leu Lys Trp Ala Phe Ser Lys His 
        2115                2120                2125


Glu Thr Ala Lys Asn Lys Met Asn Tyr Lys Gln Lys Asp Leu Asp Asn 
    2130                2135                2140


Phe Thr Ser Lys Gly Lys His Leu Leu Ser Glu Leu Lys Lys Ile His 
2145                2150                2155                2160


Ser Ser Asp Phe Ser Leu Val Lys Thr Asp Met Glu Ser Thr Val Asp 
                2165                2170                2175


Lys Trp Leu Asp Val Ser Glu Lys Leu Glu Glu Asn Met Asp Arg Leu 
            2180                2185                2190


Arg Val Ser Leu Ser Ile Trp Asp Asp Val Leu Ser Thr Arg Asp Glu 
        2195                2200                2205


Ile Glu Gly Trp Ser Asn Asn Cys Val Pro Gln Met Ala Glu Asn Ile 
    2210                2215                2220


Ser Asn Leu Asp Asn His Leu Arg Ala Glu Glu Leu Leu Lys Glu Phe 
2225                2230                2235                2240


Glu Ser Glu Val Lys Asn Lys Ala Leu Arg Leu Glu Glu Leu His Ser 
                2245                2250                2255


Lys Val Asn Asp Leu Lys Glu Leu Thr Lys Asn Leu Glu Thr Pro Pro 
            2260                2265                2270


Asp Leu Gln Phe Ile Glu Ala Asp Leu Met Gln Lys Leu Glu His Ala 
        2275                2280                2285


Lys Glu Ile Thr Glu Val Ala Lys Gly Thr Leu Lys Asp Phe Thr Ala 
    2290                2295                2300


Gln Ser Thr Gln Val Glu Lys Phe Ile Asn Asp Ile Thr Thr Trp Phe 
2305                2310                2315                2320


Thr Lys Val Glu Glu Ser Leu Met Asn Cys Ala Gln Asn Glu Thr Cys 
                2325                2330                2335


Glu Ala Leu Lys Lys Val Lys Asp Ile Gln Lys Glu Leu Gln Ser Gln 
            2340                2345                2350


Gln Ser Asn Ile Ser Ser Thr Gln Glu Asn Leu Asn Ser Leu Cys Arg 
        2355                2360                2365


Lys Tyr His Ser Ala Glu Leu Glu Ser Leu Gly Arg Ala Met Thr Gly 
    2370                2375                2380


Leu Ile Lys Lys His Glu Ala Val Ser Gln Leu Cys Ser Lys Thr Gln 
2385                2390                2395                2400


Ala Ser Leu Gln Glu Ser Leu Glu Lys His Phe Ser Glu Ser Met Gln 
                2405                2410                2415


Glu Phe Gln Glu Trp Phe Leu Gly Ala Lys Ala Ala Ala Lys Glu Ser 
            2420                2425                2430


Ser Asp Arg Thr Gly Asp Ser Lys Val Leu Glu Ala Lys Leu His Asp 
        2435                2440                2445


Leu Gln Asn Ile Leu Asp Ser Val Ser Asp Gly Gln Ser Lys Leu Asp 
    2450                2455                2460


Ala Val Thr Gln Glu Gly Gln Thr Leu Tyr Ala His Leu Ser Lys Gln 
2465                2470                2475                2480


Ile Val Ser Ser Ile Gln Glu Gln Ile Thr Lys Ala Asn Glu Glu Phe 
                2485                2490                2495


Gln Ala Phe Leu Lys Gln Cys Leu Lys Asp Lys Gln Ala Leu Gln Asp 
            2500                2505                2510


Cys Ala Ser Glu Leu Gly Ser Phe Glu Asp Gln His Arg Lys Leu Asn 
        2515                2520                2525


Leu Trp Ile His Glu Met Glu Glu Arg Phe Asn Thr Glu Asn Leu Gly 
    2530                2535                2540


Glu Ser Lys Gln His Ile Pro Glu Lys Lys Asn Glu Val His Lys Val 
2545                2550                2555                2560


Glu Met Phe Leu Gly Glu Leu Leu Ala Ala Arg Glu Ser Leu Asp Lys 
                2565                2570                2575


Leu Ser Gln Arg Gly Gln Leu Leu Ser Glu Glu Gly His Gly Ala Gly 
            2580                2585                2590


Gln Glu Gly Arg Leu Cys Ser Gln Leu Leu Thr Ser His Gln Asn Leu 
        2595                2600                2605


Leu Arg Met Thr Lys Glu Lys Leu Arg Ser Cys Gln Val Ala Leu Gln 
    2610                2615                2620


Glu His Glu Ala Leu Glu Glu Ala Leu Gln Ser Met Trp Phe Trp Val 
2625                2630                2635                2640


Lys Ala Ile Gln Asp Arg Leu Ala Cys Ala Glu Ser Thr Leu Gly Ser 
                2645                2650                2655


Lys Asp Thr Leu Glu Lys Arg Leu Ser Gln Ile Gln Asp Ile Leu Leu 
            2660                2665                2670


Met Lys Gly Glu Gly Glu Val Lys Leu Asn Met Ala Ile Gly Lys Gly 
        2675                2680                2685


Glu Gln Ala Leu Arg Ser Ser Asn Lys Glu Gly Gln Arg Val Ile Gln 
    2690                2695                2700


Thr Gln Leu Glu Thr Leu Lys Glu Val Trp Ala Asp Ile Met Ser Ser 
2705                2710                2715                2720


Ser Val His Ala Gln Ser Thr Leu Glu Ser Val Ile Ser Gln Trp Asn 
                2725                2730                2735


Asp Tyr Val Glu Arg Lys Asn Gln Leu Glu Gln Trp Met Glu Ser Val 
            2740                2745                2750


Asp Gln Lys Ile Glu His Pro Leu Gln Pro Gln Pro Gly Leu Lys Glu 
        2755                2760                2765


Lys Phe Val Leu Leu Asp His Leu Gln Ser Ile Leu Ser Glu Ala Glu 
    2770                2775                2780


Asp His Thr Arg Ala Leu His Arg Leu Ile Ala Lys Ser Arg Glu Leu 
2785                2790                2795                2800


Tyr Glu Lys Thr Glu Asp Glu Ser Phe Lys Asp Thr Ala Gln Glu Glu 
                2805                2810                2815


Leu Lys Thr Gln Phe Asn Asp Ile Met Thr Val Ala Lys Glu Lys Met 
            2820                2825                2830


Arg Lys Val Glu Glu Ile Val Lys Asp His Leu Met Tyr Leu Asp Ala 
        2835                2840                2845


Val His Glu Phe Thr Asp Trp Leu His Ser Ala Lys Glu Glu Leu His 
    2850                2855                2860


Arg Trp Ser Asp Met Ser Gly Asp Ser Ser Ala Thr Gln Lys Lys Leu 
2865                2870                2875                2880


Ser Lys Ile Lys Glu Leu Ile Asp Ser Arg Glu Ile Gly Ala Ser Arg 
                2885                2890                2895


Leu Ser Arg Val Glu Ser Leu Ala Pro Glu Val Lys Gln Asn Thr Thr 
            2900                2905                2910


Ala Ser Gly Cys Glu Leu Met His Thr Glu Met Gln Ala Leu Arg Ala 
        2915                2920                2925


Asp Trp Lys Gln Trp Glu Asp Ser Val Phe Gln Thr Gln Ser Cys Leu 
    2930                2935                2940


Glu Asn Leu Val Ser Gln Met Ala Leu Ser Glu Gln Glu Phe Ser Gly 
2945                2950                2955                2960


Gln Val Ala Gln Leu Glu Gln Ala Leu Glu Gln Phe Ser Ala Leu Leu 
                2965                2970                2975


Lys Thr Trp Ala Gln Gln Leu Thr Leu Leu Glu Gly Lys Asn Thr Asp 
            2980                2985                2990


Glu Glu Ile Val Glu Cys Trp His Lys Gly Gln Glu Ile Leu Asp Ala 
        2995                3000                3005


Leu Gln Lys Ala Glu Pro Arg Thr Glu Asp Leu Lys Ser Gln Leu Asn 
    3010                3015                3020


Glu Leu Cys Arg Phe Ser Arg Asp Leu Ser Thr Tyr Ser Gly Lys Val 
3025                3030                3035                3040


Ser Gly Leu Ile Lys Glu Tyr Asn Cys Leu Cys Leu Gln Ala Ser Lys 
                3045                3050                3055


Gly Cys Gln Asn Lys Glu Gln Ile Leu Gln Gln Arg Phe Arg Lys Ala 
            3060                3065                3070


Phe Arg Asp Phe Gln Gln Trp Leu Val Asn Ala Lys Ile Thr Thr Ala 
        3075                3080                3085


Lys Cys Phe Asp Ile Pro Gln Asn Ile Ser Glu Val Ser Thr Ser Leu 
    3090                3095                3100


Gln Lys Ile Gln Glu Phe Leu Ser Glu Ser Glu Asn Gly Gln His Lys 
3105                3110                3115                3120


Leu Asn Met Met Leu Ser Lys Gly Glu Leu Leu Ser Thr Leu Leu Thr 
                3125                3130                3135


Lys Glu Lys Ala Lys Gly Ile Gln Ala Lys Val Thr Ala Ala Lys Glu 
            3140                3145                3150


Asp Trp Lys Asn Phe His Ser Asn Leu His Gln Lys Glu Ser Ala Leu 
        3155                3160                3165


Glu Asn Leu Lys Ile Gln Met Lys Asp Phe Glu Val Ser Ala Glu Pro 
    3170                3175                3180


Ile Gln Asp Trp Leu Ser Lys Thr Glu Lys Met Val His Glu Ser Ser 
3185                3190                3195                3200


Asn Arg Leu Tyr Asp Leu Pro Ala Lys Arg Arg Glu Gln Gln Lys Leu 
                3205                3210                3215


Gln Ser Val Leu Glu Glu Ile His Cys Tyr Glu Pro Gln Leu Asn Arg 
            3220                3225                3230


Leu Lys Glu Lys Ala Gln Gln Leu Trp Glu Gly Gln Ala Ala Ser Lys 
        3235                3240                3245


Ser Phe Arg His Arg Val Ser Gln Leu Ser Ser Gln Tyr Leu Ala Leu 
    3250                3255                3260


Ser Asn Leu Thr Lys Glu Lys Val Ser Arg Leu Asp Arg Ile Val Ala 
3265                3270                3275                3280


Glu His Asn Gln Phe Ser Leu Gly Ile Lys Glu Leu Gln Asp Trp Met 
                3285                3290                3295


Thr Asp Ala Ile His Met Leu Asp Ser Tyr Cys His Pro Thr Ser Asp 
            3300                3305                3310


Lys Ser Val Leu Asp Ser Arg Thr Leu Lys Leu Glu Ala Leu Leu Ser 
        3315                3320                3325


Val Lys Gln Glu Lys Glu Ile Gln Met Lys Met Ile Val Thr Arg Gly 
    3330                3335                3340


Glu Ser Val Leu Gln Asn Thr Ser Pro Glu Gly Ile Pro Thr Ile Gln 
3345                3350                3355                3360


Gln Gln Leu Gln Ser Val Lys Asp Met Trp Ala Ser Leu Leu Ser Ala 
                3365                3370                3375


Gly Ile Arg Cys Lys Ser Gln Leu Glu Gly Ala Leu Ser Lys Trp Thr 
            3380                3385                3390


Ser Tyr Gln Asp Gly Val Arg Gln Phe Ser Gly Trp Met Asp Ser Met 
        3395                3400                3405


Glu Ala Asn Leu Asn Glu Ser Glu Arg Gln His Ala Glu Leu Arg Asp 
    3410                3415                3420


Lys Thr Thr Met Leu Gly Lys Ala Lys Leu Leu Asn Glu Glu Val Leu 
3425                3430                3435                3440


Ser Tyr Ser Ser Leu Leu Glu Thr Ile Glu Val Lys Gly Ala Gly Met 
                3445                3450                3455


Thr Glu His Tyr Val Thr Gln Leu Glu Leu Gln Asp Leu Gln Glu Arg 
            3460                3465                3470


Tyr Arg Ala Ile Gln Glu Arg Ala Lys Glu Ala Val Thr Lys Ser Glu 
        3475                3480                3485


Lys Leu Val Arg Leu His Gln Glu Tyr Gln Arg Asp Leu Lys Ala Phe 
    3490                3495                3500


Glu Val Trp Leu Gly Gln Glu Gln Glu Lys Leu Asp Gln Tyr Ser Val 
3505                3510                3515                3520


Leu Glu Gly Asp Ala His Thr His Glu Thr Thr Leu Arg Asp Leu Gln 
                3525                3530                3535


Glu Leu Gln Val His Cys Ala Glu Gly Gln Ala Leu Leu Asn Ser Val 
            3540                3545                3550


Leu His Thr Arg Glu Asp Val Ile Pro Ser Gly Ile Pro Gln Ala Glu 
        3555                3560                3565


Asp Arg Ala Leu Glu Ser Leu Arg Gln Asp Trp Gln Ala Tyr Gln His 
    3570                3575                3580


Arg Leu Ser Glu Thr Arg Thr Gln Phe Asn Asn Val Val Asn Lys Leu 
3585                3590                3595                3600


Arg Leu Met Glu Gln Lys Phe Gln Gln Val Asp Glu Trp Leu Lys Thr 
                3605                3610                3615


Ala Glu Glu Lys Val Ser Pro Arg Thr Arg Arg Gln Ser Asn Arg Ala 
            3620                3625                3630


Thr Lys Glu Ile Gln Leu His Gln Met Lys Lys Trp His Glu Glu Val 
        3635                3640                3645


Thr Ala Tyr Arg Asp Glu Val Glu Glu Val Gly Ala Arg Ala Gln Glu 
    3650                3655                3660


Ile Leu Asp Glu Ser His Val Asn Ser Arg Met Gly Cys Gln Ala Thr 
3665                3670                3675                3680


Gln Leu Thr Ser Arg Tyr Gln Ala Leu Leu Leu Gln Val Leu Glu Gln 
                3685                3690                3695


Ile Lys Phe Leu Glu Glu Glu Ile Gln Ser Leu Glu Glu Ser Glu Ser 
            3700                3705                3710


Ser Leu Ser Ser Tyr Ser Asp Trp Tyr Gly Ser Thr His Lys Asn Phe 
        3715                3720                3725


Lys Asn Val Ala Thr Lys Ile Asp Lys Val Asp Thr Val Met Met Gly 
    3730                3735                3740


Lys Lys Leu Lys Thr Leu Glu Val Leu Leu Lys Asp Met Glu Lys Gly 
3745                3750                3755                3760


His Ser Leu Leu Lys Ser Ala Arg Glu Lys Gly Glu Arg Ala Val Lys 
                3765                3770                3775


Tyr Leu Glu Glu Gly Glu Ala Glu Arg Leu Arg Lys Glu Ile His Asp 
            3780                3785                3790


His Met Glu Gln Leu Lys Glu Leu Thr Ser Thr Val Arg Lys Glu His 
        3795                3800                3805


Met Thr Leu Glu Lys Gly Leu His Leu Ala Lys Glu Phe Ser Asp Lys 
    3810                3815                3820


Cys Lys Ala Leu Thr Gln Trp Ile Ala Glu Tyr Gln Glu Ile Leu His 
3825                3830                3835                3840


Val Pro Glu Glu Pro Lys Met Glu Leu Tyr Glu Lys Lys Ala Gln Leu 
                3845                3850                3855


Ser Lys Tyr Lys Ser Leu Gln Gln Thr Val Leu Ser His Glu Pro Ser 
            3860                3865                3870


Val Lys Ser Val Arg Glu Lys Gly Glu Ala Leu Leu Glu Leu Val Gln 
        3875                3880                3885


Asp Val Thr Leu Lys Asp Lys Ile Asp Gln Leu Gln Ser Asp Tyr Gln 
    3890                3895                3900


Asp Leu Cys Ser Ile Gly Lys Glu His Val Phe Ser Leu Glu Ala Lys 
3905                3910                3915                3920


Val Lys Asp His Glu Asp Tyr Asn Ser Glu Leu Gln Glu Val Glu Lys 
                3925                3930                3935


Trp Leu Leu Gln Met Ser Gly Arg Leu Val Ala Pro Asp Leu Leu Glu 
            3940                3945                3950


Thr Ser Ser Leu Glu Thr Ile Thr Gln Gln Leu Ala His His Lys Ala 
        3955                3960                3965


Met Met Glu Glu Ile Ala Gly Phe Glu Asp Arg Leu Asn Asn Leu Gln 
    3970                3975                3980


Met Lys Gly Asp Thr Leu Ile Gly Gln Cys Ala Asp His Leu Gln Ala 
3985                3990                3995                4000


Lys Leu Lys Gln Asn Val His Ala His Leu Gln Gly Thr Lys Asp Ser 
                4005                4010                4015


Tyr Ser Ala Ile Cys Ser Thr Ala Gln Arg Met Tyr Gln Ser Leu Glu 
            4020                4025                4030


His Glu Leu Gln Lys His Val Ser Arg Gln Asp Thr Leu Gln Gln Cys 
        4035                4040                4045


Gln Ala Trp Leu Ser Ala Val Gln Pro Asp Leu Glu Pro Ser Pro Gln 
    4050                4055                4060


Pro Pro Leu Ser Arg Ala Glu Ala Ile Lys Gln Val Lys His Phe Arg 
4065                4070                4075                4080


Ala Leu Gln Glu Gln Ala Arg Thr Tyr Leu Asp Leu Leu Cys Ser Met 
                4085                4090                4095


Cys Asp Leu Ser Asn Ala Ser Val Lys Thr Thr Ala Lys Asp Ile Gln 
            4100                4105                4110


Gln Thr Glu Gln Thr Ile Glu Gln Lys Leu Val Gln Ala Gln Asn Leu 
        4115                4120                4125


Thr Gln Gly Trp Glu Glu Ile Lys His Leu Lys Ser Glu Leu Trp Ile 
    4130                4135                4140


Tyr Leu Gln Asp Ala Asp Gln Gln Leu Gln Asn Met Lys Arg Arg His 
4145                4150                4155                4160


Ser Glu Leu Glu Leu Asn Ile Ala Gln Asn Met Val Ser Gln Val Lys 
                4165                4170                4175


Asp Phe Val Lys Lys Leu Gln Ser Lys Gln Ala Ser Val Asn Thr Ile 
            4180                4185                4190


Ile Glu Lys Val Asn Lys Leu Thr Lys Lys Glu Glu Ser Pro Glu His 
        4195                4200                4205


Lys Glu Ile Asn His Leu Asn Asp Gln Trp Leu Asp Leu Cys Arg Gln 
    4210                4215                4220


Ser Asn Asn Leu Cys Leu Gln Arg Glu Glu Asp Leu Gln Arg Thr Arg 
4225                4230                4235                4240


Asp Tyr His Asp Cys Met Asn Val Val Glu Val Phe Leu Glu Lys Phe 
                4245                4250                4255


Thr Thr Glu Trp Asp Asn Leu Ala Arg Ser Asp Ala Glu Ser Thr Ala 
            4260                4265                4270


Val His Leu Glu Ala Leu Lys Lys Leu Ala Leu Ala Leu Gln Glu Arg 
        4275                4280                4285


Lys Tyr Ala Ile Glu Asp Leu Lys Asp Gln Lys Gln Lys Met Ile Glu 
    4290                4295                4300


His Leu Asn Leu Asp Asp Lys Glu Leu Val Lys Glu Gln Thr Ser His 
4305                4310                4315                4320


Leu Glu Gln Arg Trp Phe Gln Leu Glu Asp Leu Ile Lys Arg Lys Ile 
                4325                4330                4335


Gln Val Ser Val Thr Asn Leu Glu Glu Leu Asn Val Val Gln Ser Arg 
            4340                4345                4350


Phe Gln Glu Leu Met Glu Trp Ala Glu Glu Gln Gln Pro Asn Ile Ala 
        4355                4360                4365


Glu Ala Leu Lys Gln Ser Pro Pro Pro Asp Met Ala Gln Asn Leu Leu 
    4370                4375                4380


Met Asp His Leu Ala Ile Cys Ser Glu Leu Glu Ala Lys Gln Met Leu 
4385                4390                4395                4400


Leu Lys Ser Leu Ile Lys Asp Ala Asp Arg Val Met Ala Asp Leu Gly 
                4405                4410                4415


Leu Asn Glu Arg Gln Val Ile Gln Lys Ala Leu Ser Asp Ala Gln Ser 
            4420                4425                4430


His Val Asn Cys Leu Ser Asp Leu Val Gly Gln Arg Arg Lys Tyr Leu 
        4435                4440                4445


Asn Lys Ala Leu Ser Glu Lys Thr Gln Phe Leu Met Ala Val Phe Gln 
    4450                4455                4460


Ala Thr Ser Gln Ile Gln Gln His Glu Arg Lys Ile Met Phe Arg Glu 
4465                4470                4475                4480


His Ile Cys Leu Leu Pro Asp Asp Val Ser Lys Gln Val Lys Thr Cys 
                4485                4490                4495


Lys Ser Ala Gln Ala Ser Leu Lys Thr Tyr Gln Asn Glu Val Thr Gly 
            4500                4505                4510


Leu Trp Ala Gln Gly Arg Glu Leu Met Lys Glu Val Thr Glu Gln Glu 
        4515                4520                4525


Lys Ser Glu Val Leu Gly Lys Leu Gln Glu Leu Gln Ser Val Tyr Asp 
    4530                4535                4540


Ser Val Leu Gln Lys Cys Ser His Arg Leu Gln Glu Leu Glu Lys Asn 
4545                4550                4555                4560


Leu Val Ser Arg Lys His Phe Lys Glu Asp Phe Asp Lys Ala Cys His 
                4565                4570                4575


Trp Leu Lys Gln Ala Asp Ile Val Thr Phe Pro Glu Ile Asn Leu Met 
            4580                4585                4590


Asn Glu Ser Ser Glu Leu His Thr Gln Leu Ala Lys Tyr Gln Asn Ile 
        4595                4600                4605


Leu Glu Gln Ser Pro Glu Tyr Glu Asn Leu Leu Leu Thr Leu Gln Arg 
    4610                4615                4620


Thr Gly Gln Thr Ile Leu Pro Ser Leu Asn Glu Val Asp His Ser Tyr 
4625                4630                4635                4640


Leu Ser Glu Lys Leu Asn Ala Leu Pro Arg Gln Phe Asn Val Ile Val 
                4645                4650                4655


Ala Leu Ala Lys Asp Lys Phe Tyr Lys Val Gln Glu Ala Ile Leu Ala 
            4660                4665                4670


Arg Lys Glu Tyr Ala Ser Leu Ile Glu Leu Thr Thr Gln Ser Leu Ser 
        4675                4680                4685


Glu Leu Glu Ala Gln Phe Leu Arg Met Ser Lys Val Pro Thr Asp Leu 
    4690                4695                4700


Ala Val Glu Glu Ala Leu Ser Leu Gln Asp Gly Cys Arg Ala Ile Leu 
4705                4710                4715                4720


Asp Glu Val Ala Gly Leu Gly Glu Ala Val Asp Glu Leu Asn Gln Lys 
                4725                4730                4735


Lys Glu Gly Phe Arg Ser Thr Gly Gln Pro Trp Gln Pro Asp Lys Met 
            4740                4745                4750


Leu His Leu Val Thr Leu Tyr His Arg Leu Lys Arg Gln Thr Glu Gln 
        4755                4760                4765


Arg Val Ser Leu Leu Glu Asp Thr Thr Ser Ala Tyr Gln Glu His Glu 
    4770                4775                4780


Lys Met Cys Gln Gln Leu Glu Arg Gln Leu Lys Ser Val Lys Glu Glu 
4785                4790                4795                4800


Gln Ser Lys Val Asn Glu Glu Thr Leu Pro Ala Glu Glu Lys Leu Lys 
                4805                4810                4815


Met Tyr His Ser Leu Ala Gly Ser Leu Gln Asp Ser Gly Ile Val Leu 
            4820                4825                4830


Lys Arg Val Thr Ile His Leu Glu Asp Leu Ala Pro His Leu Asp Pro 
        4835                4840                4845


Leu Ala Tyr Glu Lys Ala Arg His Gln Ile Gln Ser Trp Gln Gly Glu 
    4850                4855                4860


Leu Lys Leu Leu Thr Ser Ala Ile Gly Glu Thr Val Thr Glu Cys Glu 
4865                4870                4875                4880


Ser Arg Met Val Gln Ser Ile Asp Phe Gln Thr Glu Met Ser Arg Ser 
                4885                4890                4895


Leu Asp Trp Leu Arg Arg Val Lys Ala Glu Leu Ser Gly Pro Val Tyr 
            4900                4905                4910


Leu Asp Leu Asn Leu Gln Asp Ile Gln Glu Glu Ile Arg Lys Ile Gln 
        4915                4920                4925


Ile His Gln Glu Glu Val Gln Ser Ser Leu Arg Ile Met Asn Ala Leu 
    4930                4935                4940


Ser His Lys Glu Lys Glu Lys Phe Thr Lys Ala Lys Glu Leu Ile Ser 
4945                4950                4955                4960


Ala Asp Leu Glu His Ser Leu Ala Glu Leu Ser Glu Leu Asp Gly Asp 
                4965                4970                4975


Ile Gln Glu Ala Leu Arg Thr Arg Gln Ala Thr Leu Thr Glu Ile Tyr 
            4980                4985                4990


Ser Gln Cys Gln Arg Tyr Tyr Gln Val Phe Gln Ala Ala Asn Asp Trp 
        4995                5000                5005


Leu Glu Asp Ala Gln Glu Leu Leu Gln Leu Ala Gly Asn Gly Leu Asp 
    5010                5015                5020


Val Glu Ser Ala Glu Glu Asn Leu Lys Ser His Met Glu Phe Phe Ser 
5025                5030                5035                5040


Thr Glu Asp Gln Phe His Ser Asn Leu Glu Glu Leu His Ser Leu Val 
                5045                5050                5055


Ala Thr Leu Asp Pro Leu Ile Lys Pro Thr Gly Lys Glu Asp Leu Glu 
            5060                5065                5070


Gln Lys Val Ala Ser Leu Glu Leu Arg Ser Gln Arg Met Ser Arg Asp 
        5075                5080                5085


Ser Gly Ala Gln Val Asp Leu Leu Gln Arg Cys Thr Ala Gln Trp His 
    5090                5095                5100


Asp Tyr Gln Lys Ala Arg Glu Glu Val Ile Glu Leu Met Asn Asp Thr 
5105                5110                5115                5120


Glu Lys Lys Leu Ser Glu Phe Ser Leu Leu Lys Thr Ser Ser Ser His 
                5125                5130                5135


Glu Ala Glu Glu Lys Leu Ser Glu His Lys Ala Leu Val Ser Val Val 
            5140                5145                5150


Asn Ser Phe His Glu Lys Ile Val Ala Leu Glu Glu Lys Ala Ser Gln 
        5155                5160                5165


Leu Glu Lys Thr Gly Asn Asp Ala Ser Lys Ala Thr Leu Ser Arg Ser 
    5170                5175                5180


Met Thr Thr Val Trp Gln Arg Trp Thr Arg Leu Arg Ala Val Ala Gln 
5185                5190                5195                5200


Asp Gln Glu Lys Ile Leu Glu Asp Ala Val Asp Glu Trp Thr Gly Phe 
                5205                5210                5215


Asn Asn Lys Val Lys Lys Ala Thr Glu Met Ile Asp Gln Leu Gln Asp 
            5220                5225                5230


Lys Leu Pro Gly Ser Ser Ala Glu Lys Ala Ser Lys Ala Glu Leu Leu 
        5235                5240                5245


Thr Leu Leu Glu Tyr His Asp Thr Phe Val Leu Glu Leu Glu Gln Gln 
    5250                5255                5260


Gln Ser Ala Leu Gly Met Leu Arg Gln Gln Thr Leu Ser Met Leu Gln 
5265                5270                5275                5280


Asp Gly Ala Ala Pro Thr Pro Gly Glu Glu Pro Pro Leu Met Gln Glu 
                5285                5290                5295


Ile Thr Ala Met Gln Asp Arg Cys Leu Asn Met Gln Glu Lys Val Lys 
            5300                5305                5310


Thr Asn Gly Lys Leu Val Lys Gln Glu Leu Lys Asp Arg Glu Met Val 
        5315                5320                5325


Glu Thr Gln Ile Asn Ser Val Lys Cys Trp Val Gln Glu Thr Lys Glu 
    5330                5335                5340


Tyr Leu Gly Asn Pro Thr Ile Glu Ile Asp Ala Gln Leu Glu Glu Leu 
5345                5350                5355                5360


Gln Ile Leu Leu Thr Glu Ala Thr Asn His Arg Gln Asn Ile Glu Lys 
                5365                5370                5375


Met Ala Glu Glu Gln Lys Glu Lys Tyr Leu Gly Leu Tyr Thr Ile Leu 
            5380                5385                5390


Pro Ser Glu Leu Ser Leu Gln Leu Ala Glu Val Ala Leu Asp Leu Lys 
        5395                5400                5405


Ile Arg Asp Gln Ile Gln Asp Lys Ile Lys Glu Val Glu Gln Ser Lys 
    5410                5415                5420


Ala Thr Ser Gln Glu Leu Ser Arg Gln Ile Gln Lys Leu Ala Lys Asp 
5425                5430                5435                5440


Leu Thr Thr Ile Leu Thr Lys Leu Lys Ala Lys Thr Asp Asn Val Val 
                5445                5450                5455


Gln Ala Lys Thr Asp Gln Lys Val Leu Gly Glu Glu Leu Asp Gly Cys 
            5460                5465                5470


Asn Ser Lys Leu Met Glu Leu Asp Ala Ala Val Gln Lys Phe Leu Glu 
        5475                5480                5485


Gln Asn Gly Gln Leu Gly Lys Pro Leu Ala Lys Lys Ile Gly Lys Leu 
    5490                5495                5500


Thr Glu Leu His Gln Gln Thr Ile Arg Gln Ala Glu Asn Arg Leu Ser 
5505                5510                5515                5520


Lys Leu Asn Gln Ala Ala Ser His Leu Glu Glu Tyr Asn Glu Met Leu 
                5525                5530                5535


Glu Leu Ile Leu Lys Trp Ile Glu Lys Ala Lys Val Leu Ala His Gly 
            5540                5545                5550


Thr Ile Ala Trp Asn Ser Ala Ser Gln Leu Arg Glu Gln Tyr Ile Leu 
        5555                5560                5565


His Gln Thr Leu Leu Glu Glu Ser Lys Glu Ile Asp Ser Glu Leu Glu 
    5570                5575                5580


Ala Met Thr Glu Lys Leu Gln Tyr Leu Thr Ser Val Tyr Cys Thr Glu 
5585                5590                5595                5600


Lys Met Ser Gln Gln Val Ala Glu Leu Gly Arg Glu Thr Glu Glu Leu 
                5605                5610                5615


Arg Gln Met Ile Lys Ile Arg Leu Gln Asn Leu Gln Asp Ala Ala Lys 
            5620                5625                5630


Asp Met Lys Lys Phe Glu Ala Glu Leu Lys Lys Leu Gln Ala Ala Leu 
        5635                5640                5645


Glu Gln Ala Gln Ala Thr Leu Thr Ser Pro Glu Val Gly Arg Leu Ser 
    5650                5655                5660


Leu Lys Glu Gln Leu Ser His Arg Gln His Leu Leu Ser Glu Met Glu 
5665                5670                5675                5680


Ser Leu Lys Pro Lys Val Gln Ala Val Gln Leu Cys Gln Ser Ala Leu 
                5685                5690                5695


Arg Ile Pro Glu Asp Val Val Ala Ser Leu Pro Leu Cys His Ala Ala 
            5700                5705                5710


Leu Arg Leu Gln Glu Glu Ala Ser Arg Leu Gln His Thr Ala Ile Gln 
        5715                5720                5725


Gln Cys Asn Ile Met Gln Ala Ala Val Val Gln Tyr Glu Gln Tyr Glu 
    5730                5735                5740


Gln Glu Met Lys His Leu Gln Gln Leu Ile Glu Gly Ala His Arg Glu 
5745                5750                5755                5760


Ile Glu Asp Lys Pro Val Ala Thr Ser Asn Ile Gln Glu Leu Gln Ala 
                5765                5770                5775


Gln Ile Ser Arg His Glu Glu Leu Ala Gln Lys Ile Lys Gly Tyr Gln 
            5780                5785                5790


Glu Gln Ile Ala Ser Leu Asn Ser Lys Cys Lys Met Leu Thr Met Lys 
        5795                5800                5805


Ala Lys His Ala Thr Met Leu Leu Thr Val Thr Glu Val Glu Gly Leu 
    5810                5815                5820


Ala Glu Gly Thr Glu Asp Leu Asp Gly Glu Leu Leu Pro Thr Pro Ser 
5825                5830                5835                5840


Ala His Pro Ser Val Val Met Met Thr Ala Gly Arg Cys His Thr Leu 
                5845                5850                5855


Leu Ser Pro Val Thr Glu Glu Ser Gly Glu Glu Gly Thr Asn Ser Glu 
            5860                5865                5870


Ile Ser Ser Pro Pro Ala Cys Arg Ser Pro Ser Pro Val Ala Asn Thr 
        5875                5880                5885


Asp Ala Ser Val Asn Gln Asp Ile Ala Tyr Tyr Gln Ala Leu Ser Ala 
    5890                5895                5900


Glu Arg Leu Gln Thr Asp Ala Ala Lys Ile His Pro Ser Thr Ser Ala 
5905                5910                5915                5920


Ser Gln Glu Phe Tyr Glu Pro Gly Leu Glu Pro Ser Ala Thr Ala Lys 
                5925                5930                5935


Leu Gly Asp Leu Gln Arg Ser Trp Glu Thr Leu Lys Asn Val Ile Ser 
            5940                5945                5950


Glu Lys Gln Arg Thr Leu Tyr Glu Ala Leu Glu Arg Gln Gln Lys Tyr 
        5955                5960                5965


Gln Asp Ser Leu Gln Ser Ile Ser Thr Lys Met Glu Ala Ile Glu Leu 
    5970                5975                5980


Lys Leu Ser Glu Ser Pro Glu Pro Gly Arg Ser Pro Glu Ser Gln Met 
5985                5990                5995                6000


Ala Glu His Gln Ala Leu Met Asp Glu Ile Leu Met Leu Gln Asp Glu 
                6005                6010                6015


Ile Asn Glu Leu Gln Ser Ser Leu Ala Glu Glu Leu Val Ser Glu Ser 
            6020                6025                6030


Cys Glu Ala Asp Pro Ala Glu Gln Leu Ala Leu Gln Ser Thr Leu Thr 
        6035                6040                6045


Val Leu Ala Glu Arg Met Ser Thr Ile Arg Met Lys Ala Ser Gly Lys 
    6050                6055                6060


Arg Gln Leu Leu Glu Glu Lys Leu Asn Asp Gln Leu Glu Glu Gln Arg 
6065                6070                6075                6080


Gln Glu Gln Ala Leu Gln Arg Tyr Arg Cys Glu Ala Asp Glu Leu Asp 
                6085                6090                6095


Ser Trp Leu Leu Ser Thr Lys Ala Thr Leu Asp Thr Ala Leu Ser Pro 
            6100                6105                6110


Pro Lys Glu Pro Met Asp Met Glu Ala Gln Leu Met Asp Cys Gln Asn 
        6115                6120                6125


Met Leu Val Glu Ile Glu Gln Lys Val Val Ala Leu Ser Glu Leu Ser 
    6130                6135                6140


Val His Asn Glu Asn Leu Leu Leu Glu Gly Lys Ala His Thr Lys Asp 
6145                6150                6155                6160


Glu Ala Glu Gln Leu Ala Gly Lys Leu Arg Arg Leu Lys Gly Ser Leu 
                6165                6170                6175


Leu Glu Leu Gln Arg Ala Leu His Asp Lys Gln Leu Asn Met Gln Gly 
            6180                6185                6190


Thr Ala Gln Glu Lys Glu Glu Ser Asp Val Asp Leu Thr Ala Thr Gln 
        6195                6200                6205


Ser Pro Gly Val Gln Glu Trp Leu Ala Gln Ala Arg Thr Thr Trp Thr 
    6210                6215                6220


Gln Gln Arg Gln Ser Ser Leu Gln Gln Gln Lys Glu Leu Glu Gln Glu 
6225                6230                6235                6240


Leu Ala Glu Gln Lys Ser Leu Leu Arg Ser Val Ala Ser Arg Gly Glu 
                6245                6250                6255


Glu Ile Leu Ile Gln His Ser Ala Ala Glu Thr Ser Gly Asp Ala Gly 
            6260                6265                6270


Glu Lys Pro Asp Val Leu Ser Gln Glu Leu Gly Met Glu Gly Glu Lys 
        6275                6280                6285


Ser Ser Ala Glu Asp Gln Met Arg Met Lys Trp Glu Ser Leu His Gln 
    6290                6295                6300


Glu Phe Ser Thr Lys Gln Lys Leu Leu Gln Asn Val Leu Glu Gln Glu 
6305                6310                6315                6320


Gln Glu Gln Val Leu Tyr Ser Arg Pro Asn Arg Leu Leu Ser Gly Val 
                6325                6330                6335


Pro Leu Tyr Lys Gly Asp Val Pro Thr Gln Asp Lys Ser Ala Val Thr 
            6340                6345                6350


Ser Leu Leu Asp Gly Leu Asn Gln Ala Phe Glu Glu Val Ser Ser Gln 
        6355                6360                6365


Ser Gly Gly Ala Lys Arg Gln Ser Ile His Leu Glu Gln Lys Leu Tyr 
    6370                6375                6380


Asp Gly Val Ser Ala Thr Ser Thr Trp Leu Asp Asp Val Glu Glu Arg 
6385                6390                6395                6400


Leu Phe Val Ala Thr Ala Leu Leu Pro Glu Glu Thr Glu Thr Cys Leu 
                6405                6410                6415


Phe Asn Gln Glu Ile Leu Ala Lys Asp Ile Lys Glu Met Ser Glu Glu 
            6420                6425                6430


Met Asp Lys Asn Lys Asn Leu Phe Ser Gln Ala Phe Pro Glu Asn Gly 
        6435                6440                6445


Asp Asn Arg Asp Val Ile Glu Asp Thr Leu Gly Cys Leu Leu Gly Arg 
    6450                6455                6460


Leu Ser Leu Leu Asp Ser Val Val Asn Gln Arg Cys His Gln Met Lys 
6465                6470                6475                6480


Glu Arg Leu Gln Gln Ile Leu Asn Phe Gln Asn Asp Leu Lys Val Leu 
                6485                6490                6495


Phe Thr Ser Leu Ala Asp Asn Lys Tyr Ile Ile Leu Gln Lys Leu Ala 
            6500                6505                6510


Asn Val Phe Glu Gln Pro Val Ala Glu Gln Ile Glu Ala Ile Gln Gln 
        6515                6520                6525


Ala Glu Asp Gly Leu Lys Glu Phe Asp Ala Gly Ile Ile Glu Leu Lys 
    6530                6535                6540


Arg Arg Gly Asp Lys Leu Gln Val Glu Gln Pro Ser Met Gln Glu Leu 
6545                6550                6555                6560


Ser Lys Leu Gln Asp Met Tyr Asp Glu Leu Met Met Ile Ile Gly Ser 
                6565                6570                6575


Arg Arg Ser Gly Leu Asn Gln Asn Leu Thr Leu Lys Ser Gln Tyr Glu 
            6580                6585                6590


Arg Ala Leu Gln Asp Leu Ala Asp Leu Leu Glu Thr Gly Gln Glu Lys 
        6595                6600                6605


Met Ala Gly Asp Gln Lys Ile Ile Val Ser Ser Lys Glu Glu Ile Gln 
    6610                6615                6620


Gln Leu Leu Asp Lys His Lys Glu Tyr Phe Gln Gly Leu Glu Ser His 
6625                6630                6635                6640


Met Ile Leu Thr Glu Thr Leu Phe Arg Lys Ile Ile Ser Phe Ala Val 
                6645                6650                6655


Gln Lys Glu Thr Gln Phe His Thr Glu Leu Met Ala Gln Ala Ser Ala 
            6660                6665                6670


Val Leu Lys Arg Ala His Lys Arg Gly Val Glu Leu Glu Tyr Ile Leu 
        6675                6680                6685


Glu Thr Trp Ser His Leu Asp Glu Asp Gln Gln Glu Leu Ser Arg Gln 
    6690                6695                6700


Leu Glu Val Val Glu Ser Ser Ile Pro Ser Val Gly Leu Val Glu Glu 
6705                6710                6715                6720


Asn Glu Asp Arg Leu Ile Asp Arg Ile Thr Leu Tyr Gln His Leu Lys 
                6725                6730                6735


Ser Ser Leu Asn Glu Tyr Gln Pro Lys Leu Tyr Gln Val Leu Asp Asp 
            6740                6745                6750


Gly Lys Arg Leu Leu Ile Ser Ile Ser Cys Ser Asp Leu Glu Ser Gln 
        6755                6760                6765


Leu Asn Gln Leu Gly Glu Cys Trp Leu Ser Asn Thr Asn Lys Met Ser 
    6770                6775                6780


Lys Glu Leu His Arg Leu Glu Thr Ile Leu Lys His Trp Thr Arg Tyr 
6785                6790                6795                6800


Gln Ser Glu Ser Ala Asp Leu Ile His Trp Leu Gln Ser Ala Lys Asp 
                6805                6810                6815


Arg Leu Glu Phe Trp Thr Gln Gln Ser Val Thr Val Pro Gln Glu Leu 
            6820                6825                6830


Glu Met Val Arg Asp His Leu Asn Ala Phe Leu Glu Phe Ser Lys Glu 
        6835                6840                6845


Val Asp Ala Gln Ser Ser Leu Lys Ser Ser Val Leu Ser Thr Gly Asn 
    6850                6855                6860


Gln Leu Leu Arg Leu Lys Lys Val Asp Thr Ala Thr Leu Arg Ser Glu 
6865                6870                6875                6880


Leu Ser Arg Ile Asp Ser Gln Trp Thr Asp Leu Leu Thr Asn Ile Pro 
                6885                6890                6895


Ala Val Gln Glu Lys Leu His Gln Leu Gln Met Asp Lys Leu Pro Ser 
            6900                6905                6910


Arg His Ala Ile Ser Glu Val Met Ser Trp Ile Ser Leu Met Glu Asn 
        6915                6920                6925


Val Ile Gln Lys Asp Glu Asp Asn Ile Lys Asn Ser Ile Gly Tyr Lys 
    6930                6935                6940


Ala Ile His Glu Tyr Leu Gln Lys Tyr Lys Gly Phe Lys Ile Asp Ile 
6945                6950                6955                6960


Asn Cys Lys Gln Leu Thr Val Asp Phe Val Asn Gln Ser Val Leu Gln 
                6965                6970                6975


Ile Ser Ser Gln Asp Val Glu Ser Lys Arg Ser Asp Lys Thr Asp Phe 
            6980                6985                6990


Ala Glu Gln Leu Gly Ala Met Asn Lys Ser Trp Gln Ile Leu Gln Gly 
        6995                7000                7005


Leu Val Thr Glu Lys Ile Gln Leu Leu Glu Gly Leu Leu Glu Ser Trp 
    7010                7015                7020


Ser Glu Tyr Glu Asn Asn Val Gln Cys Leu Lys Thr Trp Phe Glu Thr 
7025                7030                7035                7040


Gln Glu Lys Arg Leu Lys Gln Gln His Arg Ile Gly Asp Gln Ala Ser 
                7045                7050                7055


Val Gln Asn Ala Leu Lys Asp Cys Gln Asp Leu Glu Asp Leu Ile Lys 
            7060                7065                7070


Ala Lys Glu Lys Glu Val Glu Lys Ile Glu Gln Asn Gly Leu Ala Leu 
        7075                7080                7085


Ile Gln Asn Lys Lys Glu Asp Val Ser Ser Ile Val Met Ser Thr Leu 
    7090                7095                7100


Arg Glu Leu Gly Gln Thr Trp Ala Asn Leu Asp His Met Val Gly Gln 
7105                7110                7115                7120


Leu Lys Ile Leu Leu Lys Ser Val Leu Asp Gln Trp Ser Ser His Lys 
                7125                7130                7135


Val Ala Phe Asp Lys Ile Asn Ser Tyr Leu Met Glu Ala Arg Tyr Ser 
            7140                7145                7150


Leu Ser Arg Phe Arg Leu Leu Thr Gly Ser Leu Glu Ala Val Gln Val 
        7155                7160                7165


Gln Val Asp Asn Leu Gln Asn Leu Gln Asp Asp Leu Glu Lys Gln Glu 
    7170                7175                7180


Arg Ser Leu Gln Lys Phe Gly Ser Ile Thr Asn Gln Leu Leu Lys Glu 
7185                7190                7195                7200


Cys His Pro Pro Val Thr Glu Thr Leu Thr Asn Thr Leu Lys Glu Val 
                7205                7210                7215


Asn Met Arg Trp Asn Asn Leu Leu Glu Glu Ile Ala Glu Gln Leu Gln 
            7220                7225                7230


Ser Ser Lys Ala Leu Leu Gln Leu Trp Gln Arg Tyr Lys Asp Tyr Ser 
        7235                7240                7245


Lys Gln Cys Ala Ser Thr Val Gln Gln Gln Glu Asp Arg Thr Asn Glu 
    7250                7255                7260


Leu Leu Lys Ala Ala Thr Asn Lys Asp Ile Ala Asp Asp Glu Val Ala 
7265                7270                7275                7280


Thr Trp Ile Gln Asp Cys Asn Asp Leu Leu Lys Gly Leu Gly Thr Val 
                7285                7290                7295


Lys Asp Ser Leu Phe Phe Leu His Glu Leu Gly Glu Gln Leu Lys Gln 
            7300                7305                7310


Gln Val Asp Ala Ser Ala Ala Ser Ala Ile Gln Ser Asp Gln Leu Ser 
        7315                7320                7325


Leu Ser Gln His Leu Cys Ala Leu Glu Gln Ala Leu Cys Lys Gln Gln 
    7330                7335                7340


Thr Ser Leu Gln Ala Gly Val Leu Asp Tyr Glu Thr Phe Ala Lys Ser 
7345                7350                7355                7360


Leu Glu Ala Leu Glu Ala Trp Ile Val Glu Ala Glu Glu Ile Leu Gln 
                7365                7370                7375


Gly Gln Asp Pro Ser His Ser Ser Asp Leu Ser Thr Ile Gln Glu Arg 
            7380                7385                7390


Met Glu Glu Leu Lys Gly Gln Met Leu Lys Phe Ser Ser Met Ala Pro 
        7395                7400                7405


Asp Leu Asp Arg Leu Asn Glu Leu Gly Tyr Arg Leu Pro Leu Asn Asp 
    7410                7415                7420


Lys Glu Ile Lys Arg Met Gln Asn Leu Asn Arg His Trp Ser Leu Ile 
7425                7430                7435                7440


Ser Ser Gln Thr Thr Glu Arg Phe Ser Lys Leu Gln Ser Phe Leu Leu 
                7445                7450                7455


Gln His Gln Thr Phe Leu Glu Lys Cys Glu Thr Trp Met Glu Phe Leu 
            7460                7465                7470


Val Gln Thr Glu Gln Lys Leu Ala Val Glu Ile Ser Gly Asn Tyr Gln 
        7475                7480                7485


His Leu Leu Glu Gln Gln Arg Ala His Glu Leu Phe Gln Ala Glu Met 
    7490                7495                7500


Phe Ser Arg Gln Gln Ile Leu His Ser Ile Ile Ile Asp Gly Gln Arg 
7505                7510                7515                7520


Leu Leu Glu Gln Gly Gln Val Asp Asp Arg Asp Glu Phe Asn Leu Lys 
                7525                7530                7535


Leu Thr Leu Leu Ser Asn Gln Trp Gln Gly Val Ile Arg Arg Ala Gln 
            7540                7545                7550


Gln Arg Arg Gly Ile Ile Asp Ser Gln Ile Arg Gln Trp Gln Arg Tyr 
        7555                7560                7565


Arg Glu Met Ala Glu Lys Leu Arg Lys Trp Leu Val Glu Val Ser Tyr 
    7570                7575                7580


Leu Pro Met Ser Gly Leu Gly Ser Val Pro Ile Pro Leu Gln Gln Ala 
7585                7590                7595                7600


Arg Thr Leu Phe Asp Glu Val Gln Phe Lys Glu Lys Val Phe Leu Arg 
                7605                7610                7615


Gln Gln Gly Ser Tyr Ile Leu Thr Val Glu Ala Gly Lys Gln Leu Leu 
            7620                7625                7630


Leu Ser Ala Asp Ser Gly Ala Glu Ala Ala Leu Gln Ala Glu Leu Ala 
        7635                7640                7645


Glu Ile Gln Glu Lys Trp Lys Ser Ala Ser Met Arg Leu Glu Glu Gln 
    7650                7655                7660


Lys Lys Lys Leu Ala Phe Leu Leu Lys Asp Trp Glu Lys Cys Glu Lys 
7665                7670                7675                7680


Gly Ile Ala Asp Ser Leu Glu Lys Leu Arg Thr Phe Lys Lys Lys Leu 
                7685                7690                7695


Ser Gln Ser Leu Pro Asp His His Glu Glu Leu His Ala Glu Gln Met 
            7700                7705                7710


Arg Cys Lys Glu Leu Glu Asn Ala Val Gly Ser Trp Thr Asp Asp Leu 
        7715                7720                7725


Thr Gln Leu Ser Leu Leu Lys Asp Thr Leu Ser Ala Tyr Ile Ser Ala 
    7730                7735                7740


Asp Asp Ile Ser Ile Leu Asn Glu Arg Val Glu Leu Leu Gln Arg Gln 
7745                7750                7755                7760


Trp Glu Glu Leu Cys His Gln Leu Ser Leu Arg Arg Gln Gln Ile Gly 
                7765                7770                7775


Glu Arg Leu Asn Glu Trp Ala Val Phe Ser Glu Lys Asn Lys Glu Leu 
            7780                7785                7790


Cys Glu Trp Leu Thr Gln Met Glu Ser Lys Val Ser Gln Asn Gly Asp 
        7795                7800                7805


Ile Leu Ile Glu Glu Met Ile Glu Lys Leu Lys Lys Asp Tyr Gln Glu 
    7810                7815                7820


Glu Ile Ala Ile Ala Gln Glu Asn Lys Ile Gln Leu Gln Gln Met Gly 
7825                7830                7835                7840


Glu Arg Leu Ala Lys Ala Ser His Glu Ser Lys Ala Ser Glu Ile Glu 
                7845                7850                7855


Tyr Lys Leu Gly Lys Val Asn Asp Arg Trp Gln His Leu Leu Asp Leu 
            7860                7865                7870


Ile Ala Ala Arg Val Lys Lys Leu Lys Glu Thr Leu Val Ala Val Gln 
        7875                7880                7885


Gln Leu Asp Lys Asn Met Ser Ser Leu Arg Thr Trp Leu Ala His Ile 
    7890                7895                7900


Glu Ser Glu Leu Ala Lys Pro Ile Val Tyr Asp Ser Cys Asn Ser Glu 
7905                7910                7915                7920


Glu Ile Gln Arg Lys Leu Asn Glu Gln Gln Glu Leu Gln Arg Asp Ile 
                7925                7930                7935


Glu Lys His Ser Thr Gly Val Ala Ser Val Leu Asn Leu Cys Glu Val 
            7940                7945                7950


Leu Leu His Asp Cys Asp Ala Cys Ala Thr Asp Ala Glu Cys Asp Ser 
        7955                7960                7965


Ile Gln Gln Ala Thr Arg Asn Leu Asp Arg Arg Trp Arg Asn Ile Cys 
    7970                7975                7980


Ala Met Ser Met Glu Arg Arg Leu Lys Ile Glu Glu Thr Trp Arg Leu 
7985                7990                7995                8000


Trp Gln Lys Phe Leu Asp Asp Tyr Ser Arg Phe Glu Asp Trp Leu Lys 
                8005                8010                8015


Ser Ser Glu Arg Thr Ala Ala Phe Pro Ser Ser Ser Gly Val Ile Tyr 
            8020                8025                8030


Thr Val Ala Lys Glu Glu Leu Lys Lys Phe Glu Ala Phe Gln Arg Gln 
        8035                8040                8045


Val His Glu Cys Leu Thr Gln Leu Glu Leu Ile Asn Lys Gln Tyr Arg 
    8050                8055                8060


Arg Leu Ala Arg Glu Asn Arg Thr Asp Ser Ala Cys Ser Leu Lys Gln 
8065                8070                8075                8080


Met Val His Glu Gly Asn Gln Arg Trp Asp Asn Leu Gln Lys Arg Val 
                8085                8090                8095


Thr Ser Ile Leu Arg Arg Leu Lys His Phe Ile Gly Gln Arg Glu Glu 
            8100                8105                8110


Phe Glu Thr Ala Arg Asp Ser Ile Leu Val Trp Leu Thr Glu Met Asp 
        8115                8120                8125


Leu Gln Leu Thr Asn Ile Glu His Phe Ser Glu Cys Asp Val Gln Ala 
    8130                8135                8140


Lys Ile Lys Gln Leu Lys Ala Phe Gln Gln Glu Ile Ser Leu Asn His 
8145                8150                8155                8160


Asn Lys Ile Glu Gln Ile Ile Ala Gln Gly Glu Gln Leu Ile Glu Lys 
                8165                8170                8175


Ser Glu Pro Leu Asp Ala Ala Ile Ile Glu Glu Glu Leu Asp Glu Leu 
            8180                8185                8190


Arg Arg Tyr Cys Gln Glu Val Phe Gly Arg Val Glu Arg Tyr His Lys 
        8195                8200                8205


Lys Leu Ile Arg Leu Pro Leu Pro Asp Asp Glu His Asp Leu Ser Asp 
    8210                8215                8220


Arg Glu Leu Glu Leu Glu Asp Ser Ala Ala Leu Ser Asp Leu His Trp 
8225                8230                8235                8240


His Asp Arg Ser Ala Asp Ser Leu Leu Ser Pro Gln Pro Ser Ser Asn 
                8245                8250                8255


Leu Ser Leu Ser Leu Ala Gln Pro Leu Arg Ser Glu Arg Ser Gly Arg 
            8260                8265                8270


Asp Thr Pro Ala Ser Val Asp Ser Ile Pro Leu Glu Trp Asp His Asp 
        8275                8280                8285


Tyr Asp Leu Ser Arg Asp Leu Glu Ser Ala Met Ser Arg Ala Leu Pro 
    8290                8295                8300


Ser Glu Asp Glu Glu Gly Gln Asp Asp Lys Asp Phe Tyr Leu Arg Gly 
8305                8310                8315                8320


Ala Val Gly Leu Ser Gly Asp His Ser Ala Leu Glu Ser Gln Ile Arg 
                8325                8330                8335


Gln Leu Gly Lys Ala Leu Asp Asp Ser Arg Phe Gln Ile Gln Gln Thr 
            8340                8345                8350


Glu Asn Ile Ile Arg Ser Lys Thr Pro Thr Gly Pro Glu Leu Asp Thr 
        8355                8360                8365


Ser Tyr Lys Gly Tyr Met Lys Leu Leu Gly Glu Cys Ser Ser Ser Ile 
    8370                8375                8380


Asp Ser Val Lys Arg Leu Glu His Lys Leu Lys Glu Glu Glu Glu Ser 
8385                8390                8395                8400


Leu Pro Gly Phe Val Asn Leu His Ser Thr Glu Thr Gln Thr Ala Gly 
                8405                8410                8415


Val Ile Asp Arg Trp Glu Leu Leu Gln Ala Gln Ala Leu Ser Lys Glu 
            8420                8425                8430


Leu Arg Met Lys Gln Asn Leu Gln Lys Trp Gln Gln Phe Asn Ser Asp 
        8435                8440                8445


Leu Asn Ser Ile Trp Ala Trp Leu Gly Asp Thr Glu Glu Glu Leu Glu 
    8450                8455                8460


Gln Leu Gln Arg Leu Glu Leu Ser Thr Asp Ile Gln Thr Ile Glu Leu 
8465                8470                8475                8480


Gln Ile Lys Lys Leu Lys Glu Leu Gln Lys Ala Val Asp His Arg Lys 
                8485                8490                8495


Ala Ile Ile Leu Ser Ile Asn Leu Cys Ser Pro Glu Phe Thr Gln Ala 
            8500                8505                8510


Asp Ser Lys Glu Ser Arg Asp Leu Gln Asp Arg Leu Ser Gln Met Asn 
        8515                8520                8525


Gly Arg Trp Asp Arg Val Cys Ser Leu Leu Glu Glu Trp Arg Gly Leu 
    8530                8535                8540


Leu Gln Asp Ala Leu Met Gln Cys Gln Gly Phe His Glu Met Ser His 
8545                8550                8555                8560


Gly Leu Leu Leu Met Leu Glu Asn Ile Asp Arg Arg Lys Asn Glu Ile 
                8565                8570                8575


Val Pro Ile Asp Ser Asn Leu Asp Ala Glu Ile Leu Gln Asp His His 
            8580                8585                8590


Lys Gln Leu Met Gln Ile Lys His Glu Leu Leu Glu Ser Gln Leu Arg 
        8595                8600                8605


Val Ala Ser Leu Gln Asp Met Ser Cys Gln Leu Leu Val Asn Ala Glu 
    8610                8615                8620


Gly Thr Asp Cys Leu Glu Ala Lys Glu Lys Val His Val Ile Gly Asn 
8625                8630                8635                8640


Arg Leu Lys Leu Leu Leu Lys Glu Val Ser Arg His Ile Lys Glu Leu 
                8645                8650                8655


Glu Lys Leu Leu Asp Val Ser Ser Ser Gln Gln Asp Leu Ser Ser Trp 
            8660                8665                8670


Ser Ser Ala Asp Glu Leu Asp Thr Ser Gly Ser Val Ser Pro Thr Ser 
        8675                8680                8685


Gly Arg Ser Thr Pro Asn Arg Gln Lys Thr Pro Arg Gly Lys Cys Ser 
    8690                8695                8700


Leu Ser Gln Pro Gly Pro Ser Val Ser Ser Pro His Ser Arg Ser Thr 
8705                8710                8715                8720


Lys Gly Gly Ser Asp Ser Ser Leu Ser Glu Pro Gly Pro Gly Arg Ser 
                8725                8730                8735


Gly Arg Gly Phe Leu Phe Arg Val Leu Arg Ala Ala Leu Pro Leu Gln 
            8740                8745                8750


Leu Leu Leu Leu Leu Leu Ile Gly Leu Ala Cys Leu Val Pro Met Ser 
        8755                8760                8765


Glu Glu Asp Tyr Ser Cys Ala Leu Ser Asn Asn Phe Ala Arg Ser Phe 
    8770                8775                8780


His Pro Met Leu Arg Tyr Thr Asn Gly Pro Pro Pro Leu 
8785                8790                8795


<210>  392
<211>  5826
<212>  DNA
<213>  Homo sapiens

<400>  392
gaggaggaga cggcatccag tacagagggg ctggacttgg acccctgcag cagccctgca     60

caggagaagc ggcatataaa gccgcgctgc ccgggagccg ctcggccacg tccaccggag    120

catcctgcac tgcagggccg gtctctcgct ccagcagagc ctgcgccttt ctgactcggt    180

ccggaacact gaaaccagtc atcactgcat ctttttggca aaccaggagc tcagctgcag    240

gaggcaggat ggtctggagg ctggtcctgc tggctctgtg ggtgtggccc agcacgcaag    300

ctggtcacca ggacaaagac acgaccttcg accttttcag tatcagcaac atcaaccgca    360

agaccattgg cgccaagcag ttccgcgggc ccgaccccgg cgtgccggct taccgcttcg    420

tgcgctttga ctacatccca ccggtgaacg cagatgacct cagcaagatc accaagatca    480

tgcggcagaa ggagggcttc ttcctcacgg cccagctcaa gcaggacggc aagtccaggg    540

gcacgctgtt ggctctggag ggccccggtc tctcccagag gcagttcgag atcgtctcca    600

acggccccgc ggacacgctg gatctcacct actggattga cggcacccgg catgtggtct    660

ccctggagga cgtcggcctg gctgactcgc agtggaagaa cgtcaccgtg caggtggctg    720

gcgagaccta cagcttgcac gtgggctgcg acctcataga cagcttcgct ctggacgagc    780

ccttctacga gcacctgcag gcggaaaaga gccggatgta cgtggccaaa ggctctgcca    840

gagagagtca cttcaggggt ttgcttcaga acgtccacct agtgtttgaa aactctgtgg    900

aagatattct aagcaagaag ggttgccagc aaggccaggg agctgagatc aacgccatca    960

gtgagaacac agagacgctg cgcctgggtc cgcatgtcac caccgagtac gtgggcccca   1020

gctcggagag gaggcccgag gtgtgcgaac gctcgtgcga ggagctggga aacatggtcc   1080

aggagctctc ggggctccac gtcctcgtga accagctcag cgagaacctc aagagagtgt   1140

cgaatgataa ccagtttctc tgggagctca ttggtggccc tcctaagaca aggaacatgt   1200

cagcttgctg gcaggatggc cggttctttg cggaaaatga aacgtgggtg gtggacagct   1260

gcaccacgtg tacctgcaag aaatttaaaa ccatttgcca ccaaatcacc tgcccgcctg   1320

caacctgcgc cagtccatcc tttgtggaag gcgaatgctg cccttcctgc ctccactcgg   1380

tggacggtga ggagggctgg tctccgtggg cagagtggac ccagtgctcc gtgacgtgtg   1440

gctctgggac ccagcagaga ggccggtcct gtgacgtcac cagcaacacc tgcttggggc   1500

cctccatcca gacacgggct tgcagtctga gcaagtgtga cacccgcatc cggcaggacg   1560

gcggctggag ccactggtca ccttggtctt catgctctgt gacctgtgga gttggcaata   1620

tcacacgcat ccgtctctgc aactccccag tgccccagat ggggggcaag aattgcaaag   1680

ggagtggccg ggagaccaaa gcctgccagg gcgccccatg cccaatcgat ggccgctgga   1740

gcccctggtc cccgtggtcg gcctgcactg tcacctgtgc cggtgggatc cgggagcgca   1800

cccgggtctg caacagccct gagcctcagt acggagggaa ggcctgcgtg ggggatgtgc   1860

aggagcgtca gatgtgcaac aagaggagct gccccgtgga tggctgttta tccaacccct   1920

gcttcccggg agcccagtgc agcagcttcc ccgatgggtc ctggtcatgc ggctcctgcc   1980

ctgtgggctt cttgggcaat ggcacccact gtgaggacct ggacgagtgt gccctggtcc   2040

ccgacatctg cttctccacc agcaaggtgc ctcgctgtgt caacactcag cctggcttcc   2100

actgcctgcc ctgcccgccc cgatacagag ggaaccagcc cgtcggggtc ggcctggaag   2160

cagccaagac ggaaaagcaa gtgtgtgagc ccgaaaaccc atgcaaggac aagacacaca   2220

actgccacaa gcacgcggag tgcatctacc tgggccactt cagcgacccc atgtacaagt   2280

gcgagtgcca gacaggctac gcgggcgacg ggctcatctg cggggaggac tcggacctgg   2340

acggctggcc caacctcaat ctggtctgcg ccaccaacgc cacctaccac tgcatcaagg   2400

ataactgccc ccatctgcca aattctgggc aggaagactt tgacaaggac gggattggcg   2460

atgcctgtga tgatgacgat gacaatgacg gtgtgaccga tgagaaggac aactgccagc   2520

tcctcttcaa tccccgccag gctgactatg acaaggatga ggttggggac cgctgtgaca   2580

actgccctta cgtgcacaac cctgcccaga tcgacacaga caacaatgga gagggtgacg   2640

cctgctccgt ggacattgat ggggacgatg tcttcaatga acgagacaat tgtccctacg   2700

tctacaacac tgaccagagg gacacggatg gtgacggtgt gggggatcac tgtgacaact   2760

gccccctggt gcacaaccct gaccagaccg acgtggacaa tgaccttgtt ggggaccagt   2820

gtgacaacaa cgaggacata gatgacgacg gccaccagaa caaccaggac aactgcccct   2880

acatctccaa cgccaaccag gctgaccatg acagagacgg ccagggcgac gcctgtgacc   2940

ctgatgatga caacgatggc gtccccgatg acagggacaa ctgccggctt gtgttcaacc   3000

cagaccagga ggacttggac ggtgatggac ggggtgatat ttgtaaagat gattttgaca   3060

atgacaacat cccagatatt gatgatgtgt gtcctgaaaa caatgccatc agtgagacag   3120

acttcaggaa cttccagatg gtccccttgg atcccaaagg gaccacccaa attgatccca   3180

actgggtcat tcgccatcaa ggcaaggagc tggttcagac agccaactcg gaccccggca   3240

tcgctgtagg ttttgacgag tttgggtctg tggacttcag tggcacattc tacgtaaaca   3300

ctgaccggga cgacgactat gccggcttcg tctttggtta ccagtcaagc agccgcttct   3360

atgtggtgat gtggaagcag gtgacgcaga cctactggga ggaccagccc acgcgggcct   3420

atggctactc cggcgtgtcc ctcaaggtgg tgaactccac cacggggacg ggcgagcacc   3480

tgaggaacgc gctgtggcac acggggaaca cgccggggca ggtgcgaacc ttatggcacg   3540

accccaggaa cattggctgg aaggactaca cggcctatag gtggcacctg actcacaggc   3600

ccaagactgg ctacatcaga gtcttagtgc atgaaggaaa acaggtcatg gcagactcag   3660

gacctatcta tgaccaaacc tacgctggcg ggcggctggg tctatttgtc ttctctcaag   3720

aaatggtcta tttctcagac ctcaagtacg aatgcagaga tatttaaaca agatttgctg   3780

catttccggc aatgccctgt gcatgccatg gtccctagac acctcagttc attgtggtcc   3840

ttgtggcttc tctctctagc agcacctcct gtcccttgac cttaactctg atggttcttc   3900

acctcctgcc agcaacccca aacccaagtg ccttcagagg ataaatatca atggaactca   3960

gagatgaaca tctaacccac tagaggaaac cagtttggtg atatatgaga ctttatgtgg   4020

agtgaaaatt gggcatgcca ttacattgct ttttcttgtt tgtttaaaaa gaatgacgtt   4080

tacatataaa atgtaattac ttattgtatt tatgtgtata tggagttgaa gggaatactg   4140

tgcataagcc attatgataa attaagcatg aaaaatattg ctgaactact tttggtgctt   4200

aaagttgtca ctattcttga attagagttg ctctacaatg acacacaaat cccattaaat   4260

aaattataaa caagggtcaa ttcaaatttg aagtaatgtt ttagtaagga gagattagaa   4320

gacaacaggc atagcaaatg acataagcta ccgattaact aatcggaaca tgtaaaacag   4380

ttacaaaaat aaacgaactc tcctcttgtc ctacaatgaa agccctcatg tgcagtagag   4440

atgcagtttc atcaaagaac aaacatcctt gcaaatgggt gtgacgcggt tccagatgtg   4500

gatttggcaa aacctcattt aagtaaaagg ttagcagagc aaagtgcggt gctttagctg   4560

ctgcttgtgc cgctgtggcg tcggggaggc tcctgcctga gcttccttcc ccagctttgc   4620

tgcctgagag gaaccagagc agacgcacag gccggaaaag gcgcatctaa cgcgtatcta   4680

ggctttggta actgcggaca agttgctttt acctgatttg atgatacatt tcattaaggt   4740

tccagttata aatattttgt taatatttat taagtgacta tagaatgcaa ctccatttac   4800

cagtaactta ttttaaatat gcctagtaac acatatgtag tataatttct agaaacaaac   4860

atctaataag tatataatcc tgtgaaaata tgaggcttga taatattagg ttgtcacgat   4920

gaagcatgct agaagctgta acagaataca tagagaataa tgaggagttt atgatggaac   4980

cttaaatata taatgttgcc agcgatttta gttcaatatt tgttactgtt atctatctgc   5040

tgtatatgga attcttttaa ttcaaacgct gaaaagaatc agcatttagt cttgccaggc   5100

acacccaata atcagtcatg tgtaatatgc acaagtttgt ttttgttttt gttttttttg   5160

ttggttggtt tgtttttttg ctttaagttg catgatcttt ctgcaggaaa tagtcactca   5220

tcccactcca cataaggggt ttagtaagag aagtctgtct gtctgatgat ggataggggg   5280

caaatctttt tcccctttct gttaatagtc atcacatttc tatgccaaac aggaacaatc   5340

cataacttta gtcttaatgt acacattgca ttttgataaa attaattttg ttgtttcctt   5400

tgaggttgat cgttgtgttg ttgttttgct gcacttttta cttttttgcg tgtggagctg   5460

tattcccgag accaacgaag cgttgggata cttcattaaa tgtagcgact gtcaacagcg   5520

tgcaggtttt ctgtttctgt gttgtggggt caaccgtaca atggtgtggg agtgacgatg   5580

atgtgaatat ttagaatgta ccatattttt tgtaaattat ttatgttttt ctaaacaaat   5640

ttatcgtata ggttgatgaa acgtcatgtg ttttgccaaa gactgtaaat atttatttat   5700

gtgttcacat ggtcaaaatt tcaccactga aaccctgcac ttagctagaa cctcattttt   5760

aaagattaac aacaggaaat aaattgtaaa aaaggttttc tatacatgaa aaaaaaaaaa   5820

aaaaaa                                                              5826


<210>  393
<211>  1172
<212>  PRT
<213>  Homo sapiens

<400>  393

Met Val Trp Arg Leu Val Leu Leu Ala Leu Trp Val Trp Pro Ser Thr 
1               5                   10                  15


Gln Ala Gly His Gln Asp Lys Asp Thr Thr Phe Asp Leu Phe Ser Ile 
            20                  25                  30


Ser Asn Ile Asn Arg Lys Thr Ile Gly Ala Lys Gln Phe Arg Gly Pro 
        35                  40                  45


Asp Pro Gly Val Pro Ala Tyr Arg Phe Val Arg Phe Asp Tyr Ile Pro 
    50                  55                  60


Pro Val Asn Ala Asp Asp Leu Ser Lys Ile Thr Lys Ile Met Arg Gln 
65                  70                  75                  80


Lys Glu Gly Phe Phe Leu Thr Ala Gln Leu Lys Gln Asp Gly Lys Ser 
                85                  90                  95


Arg Gly Thr Leu Leu Ala Leu Glu Gly Pro Gly Leu Ser Gln Arg Gln 
            100                 105                 110


Phe Glu Ile Val Ser Asn Gly Pro Ala Asp Thr Leu Asp Leu Thr Tyr 
        115                 120                 125


Trp Ile Asp Gly Thr Arg His Val Val Ser Leu Glu Asp Val Gly Leu 
    130                 135                 140


Ala Asp Ser Gln Trp Lys Asn Val Thr Val Gln Val Ala Gly Glu Thr 
145                 150                 155                 160


Tyr Ser Leu His Val Gly Cys Asp Leu Ile Asp Ser Phe Ala Leu Asp 
                165                 170                 175


Glu Pro Phe Tyr Glu His Leu Gln Ala Glu Lys Ser Arg Met Tyr Val 
            180                 185                 190


Ala Lys Gly Ser Ala Arg Glu Ser His Phe Arg Gly Leu Leu Gln Asn 
        195                 200                 205


Val His Leu Val Phe Glu Asn Ser Val Glu Asp Ile Leu Ser Lys Lys 
    210                 215                 220


Gly Cys Gln Gln Gly Gln Gly Ala Glu Ile Asn Ala Ile Ser Glu Asn 
225                 230                 235                 240


Thr Glu Thr Leu Arg Leu Gly Pro His Val Thr Thr Glu Tyr Val Gly 
                245                 250                 255


Pro Ser Ser Glu Arg Arg Pro Glu Val Cys Glu Arg Ser Cys Glu Glu 
            260                 265                 270


Leu Gly Asn Met Val Gln Glu Leu Ser Gly Leu His Val Leu Val Asn 
        275                 280                 285


Gln Leu Ser Glu Asn Leu Lys Arg Val Ser Asn Asp Asn Gln Phe Leu 
    290                 295                 300


Trp Glu Leu Ile Gly Gly Pro Pro Lys Thr Arg Asn Met Ser Ala Cys 
305                 310                 315                 320


Trp Gln Asp Gly Arg Phe Phe Ala Glu Asn Glu Thr Trp Val Val Asp 
                325                 330                 335


Ser Cys Thr Thr Cys Thr Cys Lys Lys Phe Lys Thr Ile Cys His Gln 
            340                 345                 350


Ile Thr Cys Pro Pro Ala Thr Cys Ala Ser Pro Ser Phe Val Glu Gly 
        355                 360                 365


Glu Cys Cys Pro Ser Cys Leu His Ser Val Asp Gly Glu Glu Gly Trp 
    370                 375                 380


Ser Pro Trp Ala Glu Trp Thr Gln Cys Ser Val Thr Cys Gly Ser Gly 
385                 390                 395                 400


Thr Gln Gln Arg Gly Arg Ser Cys Asp Val Thr Ser Asn Thr Cys Leu 
                405                 410                 415


Gly Pro Ser Ile Gln Thr Arg Ala Cys Ser Leu Ser Lys Cys Asp Thr 
            420                 425                 430


Arg Ile Arg Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser 
        435                 440                 445


Cys Ser Val Thr Cys Gly Val Gly Asn Ile Thr Arg Ile Arg Leu Cys 
    450                 455                 460


Asn Ser Pro Val Pro Gln Met Gly Gly Lys Asn Cys Lys Gly Ser Gly 
465                 470                 475                 480


Arg Glu Thr Lys Ala Cys Gln Gly Ala Pro Cys Pro Ile Asp Gly Arg 
                485                 490                 495


Trp Ser Pro Trp Ser Pro Trp Ser Ala Cys Thr Val Thr Cys Ala Gly 
            500                 505                 510


Gly Ile Arg Glu Arg Thr Arg Val Cys Asn Ser Pro Glu Pro Gln Tyr 
        515                 520                 525


Gly Gly Lys Ala Cys Val Gly Asp Val Gln Glu Arg Gln Met Cys Asn 
    530                 535                 540


Lys Arg Ser Cys Pro Val Asp Gly Cys Leu Ser Asn Pro Cys Phe Pro 
545                 550                 555                 560


Gly Ala Gln Cys Ser Ser Phe Pro Asp Gly Ser Trp Ser Cys Gly Ser 
                565                 570                 575


Cys Pro Val Gly Phe Leu Gly Asn Gly Thr His Cys Glu Asp Leu Asp 
            580                 585                 590


Glu Cys Ala Leu Val Pro Asp Ile Cys Phe Ser Thr Ser Lys Val Pro 
        595                 600                 605


Arg Cys Val Asn Thr Gln Pro Gly Phe His Cys Leu Pro Cys Pro Pro 
    610                 615                 620


Arg Tyr Arg Gly Asn Gln Pro Val Gly Val Gly Leu Glu Ala Ala Lys 
625                 630                 635                 640


Thr Glu Lys Gln Val Cys Glu Pro Glu Asn Pro Cys Lys Asp Lys Thr 
                645                 650                 655


His Asn Cys His Lys His Ala Glu Cys Ile Tyr Leu Gly His Phe Ser 
            660                 665                 670


Asp Pro Met Tyr Lys Cys Glu Cys Gln Thr Gly Tyr Ala Gly Asp Gly 
        675                 680                 685


Leu Ile Cys Gly Glu Asp Ser Asp Leu Asp Gly Trp Pro Asn Leu Asn 
    690                 695                 700


Leu Val Cys Ala Thr Asn Ala Thr Tyr His Cys Ile Lys Asp Asn Cys 
705                 710                 715                 720


Pro His Leu Pro Asn Ser Gly Gln Glu Asp Phe Asp Lys Asp Gly Ile 
                725                 730                 735


Gly Asp Ala Cys Asp Asp Asp Asp Asp Asn Asp Gly Val Thr Asp Glu 
            740                 745                 750


Lys Asp Asn Cys Gln Leu Leu Phe Asn Pro Arg Gln Ala Asp Tyr Asp 
        755                 760                 765


Lys Asp Glu Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Val His Asn 
    770                 775                 780


Pro Ala Gln Ile Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ser 
785                 790                 795                 800


Val Asp Ile Asp Gly Asp Asp Val Phe Asn Glu Arg Asp Asn Cys Pro 
                805                 810                 815


Tyr Val Tyr Asn Thr Asp Gln Arg Asp Thr Asp Gly Asp Gly Val Gly 
            820                 825                 830


Asp His Cys Asp Asn Cys Pro Leu Val His Asn Pro Asp Gln Thr Asp 
        835                 840                 845


Val Asp Asn Asp Leu Val Gly Asp Gln Cys Asp Asn Asn Glu Asp Ile 
    850                 855                 860


Asp Asp Asp Gly His Gln Asn Asn Gln Asp Asn Cys Pro Tyr Ile Ser 
865                 870                 875                 880


Asn Ala Asn Gln Ala Asp His Asp Arg Asp Gly Gln Gly Asp Ala Cys 
                885                 890                 895


Asp Pro Asp Asp Asp Asn Asp Gly Val Pro Asp Asp Arg Asp Asn Cys 
            900                 905                 910


Arg Leu Val Phe Asn Pro Asp Gln Glu Asp Leu Asp Gly Asp Gly Arg 
        915                 920                 925


Gly Asp Ile Cys Lys Asp Asp Phe Asp Asn Asp Asn Ile Pro Asp Ile 
    930                 935                 940


Asp Asp Val Cys Pro Glu Asn Asn Ala Ile Ser Glu Thr Asp Phe Arg 
945                 950                 955                 960


Asn Phe Gln Met Val Pro Leu Asp Pro Lys Gly Thr Thr Gln Ile Asp 
                965                 970                 975


Pro Asn Trp Val Ile Arg His Gln Gly Lys Glu Leu Val Gln Thr Ala 
            980                 985                 990


Asn Ser Asp Pro Gly Ile Ala Val Gly Phe Asp Glu Phe Gly Ser Val 
        995                 1000                1005


Asp Phe Ser Gly Thr Phe Tyr Val Asn Thr Asp Arg Asp Asp Asp Tyr 
    1010                1015                1020


Ala Gly Phe Val Phe Gly Tyr Gln Ser Ser Ser Arg Phe Tyr Val Val 
1025                1030                1035                1040


Met Trp Lys Gln Val Thr Gln Thr Tyr Trp Glu Asp Gln Pro Thr Arg 
                1045                1050                1055


Ala Tyr Gly Tyr Ser Gly Val Ser Leu Lys Val Val Asn Ser Thr Thr 
            1060                1065                1070


Gly Thr Gly Glu His Leu Arg Asn Ala Leu Trp His Thr Gly Asn Thr 
        1075                1080                1085


Pro Gly Gln Val Arg Thr Leu Trp His Asp Pro Arg Asn Ile Gly Trp 
    1090                1095                1100


Lys Asp Tyr Thr Ala Tyr Arg Trp His Leu Thr His Arg Pro Lys Thr 
1105                1110                1115                1120


Gly Tyr Ile Arg Val Leu Val His Glu Gly Lys Gln Val Met Ala Asp 
                1125                1130                1135


Ser Gly Pro Ile Tyr Asp Gln Thr Tyr Ala Gly Gly Arg Leu Gly Leu 
            1140                1145                1150


Phe Val Phe Ser Gln Glu Met Val Tyr Phe Ser Asp Leu Lys Tyr Glu 
        1155                1160                1165


Cys Arg Asp Ile 
    1170


<210>  394
<211>  11191
<212>  DNA
<213>  Homo sapiens

<400>  394
ccgcgcgaac atggccgaag tcggcgagga cagcggcgcc cgcgccctgc tcgcgctgcg     60

ctcggcgccc tgcagcccag tgctgtgcgc cgcagccgcc gccgccgcct tccccgcggc    120

cgcacccccg ccggcccccg cgcagcccca gcctccgccc gggccgccgc cgccgccgcc    180

accgccgctg cctccgggcg cgatcgcggg cgcgggctcc tccgggggct cctccggggt    240

atccggggac tccgcggtcg cgggcgcggc gccggccctg gtggccgcgg cggccgcctc    300

ggtacggcag agcccggggc cggcgctggc gcggctggag ggccgcgagt tcgagttcct    360

catgcgccag cccagcgtca ccatcggccg caactcgtcg cagggctcgg tggacttgag    420

catgggcctg tccagcttca tctcgcggcg ccacctgcag ctcagcttcc aggagccgca    480

cttctacctg cgctgcctcg gcaagaacgg cgtcttcgtg gacggggcct tccagagacg    540

cggcgcgccc gccctgcagc tgcccaagca gtgtaccttc cggtttccca gcacggccat    600

caagatccag ttcacgtcgc tctatcacaa agaagaggcc ccagcctccc cgctgcggcc    660

actgtacccc cagatctccc ctctgaagat ccacatcccg gagccggacc tccggagcat    720

ggtcagcccc gtcccctccc cgacgggcac catcagtgtc cccaactcct gcccagccag    780

tccacgcggt gccggctcct ccagttaccg ctttgtgcag aacgtgacct cggacctgca    840

gctggcagca gagtttgcag caaaggccgc gtcggagcag caggcagaca cgtctggagg    900

agacagcccc aaggatgagt caaagccgcc gttctcctac gcgcagctga tcgtgcaggc    960

catctcctcc gcccaggacc ggcagctgac cctgagcggg atctacgccc acatcaccaa   1020

gcattacccc tactaccgga cggccgacaa aggctggcag aattctatcc ggcacaacct   1080

ctctttgaac cgttacttta tcaaagtccc acgttcccag gaggagcctg ggaaggggtc   1140

cttttggcga atagaccctg cctctgaagc caagctcgtg gaacaggcat tccggaaacg   1200

gaggcagagg ggtgtctcct gcttccgcac ccccttcggg cctctgtcct caaggagcgc   1260

tccagcttcg cccacacacc ccgggctgat gtcccctcgc tccggcggcc tgcagacccc   1320

agagtgcctg tctcgggagg gctcccccat tccacacgac cctgagtttg ggtccaagtt   1380

agcttctgtc ccagagtacc ggtattccca aagcgcaccc ggctcccccg tcagcgccca   1440

gccagtgatc atggccgtgc ctccccgacc gtccagcctc gtggccaagc ccgtggccta   1500

catgcccgcc tccatcgtaa cctcacagca gcccgcgggc cacgccatcc acgtcgtgca   1560

gcaggccccc accgtcacca tggtcagggt ggtcaccaca tctgccaact cggccaacgg   1620

atacatcctc accagccagg gcgcggcggg gggctcccat gatgcggcgg gcgcagccgt   1680

gctggacctg ggcagcgagg ccagaggcct ggaggagaaa cccaccattg cgtttgccac   1740

aatccccgcg gctggtggag tcatccagac ggtggccagc cagatggccc ccggggtccc   1800

cggacacacg gtcaccatcc tgcagcccgc cacacccgtg accctcgggc agcaccacct   1860

tccagtccgg gccgtgaccc agaacggaaa gcatgcggtt cccacgaaca gtttagccgg   1920

caacgcttac gccctcacca gccctttgca gctccttgcg acccaagcga gttcatccgc   1980

gccggtggtg gtcacccggg tgtgcgaggt ggggcccaag gagccagcag cagccgtcgc   2040

ggccacggcc accaccaccc cagccactgc caccaccgcc tctgcctccg cctcttccac   2100

tggagagccc gaggtcaaaa ggtcccgggt ggaggagccc agtggggctg taaccacacc   2160

ggctggagtg atcgcagctg ccggccccca ggggccaggc accggggagt gaggtcacct   2220

gcaacgcggg ggagtgggac tcacccagcg gcgaccccga agctggaccc ggcagctcag   2280

gcggccgcac ccacagacgg aggagaacag cccgcggcgg cctgtgggca tcggcggcac   2340

ctggacacac ccagcccttt ccatttgatc gcctgccttc ccgtggttta agacaaaaac   2400

acataaacaa gttcagacaa ctgattgtat gattctggga attctttgct ttcctttcct   2460

tctccctcgg caccacctcc tctccccagg cctccctgtc gggcatgggg aggaggttgg   2520

agctcagcat cttgaggaat gtgtcaagac agcccctccg ctccgcgctg cacggccagc   2580

cgcctttgtc cgggaggaca gacagaaacg cagcaaggca cacaccaagg ctgccgggga   2640

ggcccgggca ccggacagat gcctgttggg aagccaggag ctgccgagcc acggaccacc   2700

taacagcctc tccgcccgga acgtgacata gagagtgttg gcattaactc ggggggtgtc   2760

cgatttcact tcagacccca agtttttctt tgtttgttta aacatggaat tcagacttca   2820

ttgtacacct gagacagaca caaaagggat catgtatttt tgaggatttt acctgttgac   2880

gtctgatgac cggccgtagg tccagggttc ccgctgggtt taatcccctc gaagagtaaa   2940

cctgccgctc tgtctgataa cttcaagtaa gagcagcggc ttcctgggtt ggcgttcgcg   3000

gtggaaggtt cctaggatga aaggtgagcc tggatccgcc ggccgcagac atcgcgctgc   3060

tggggacgat tggggccgct gctctgcaga ccagaccttc ccgaattatc cgtggctccg   3120

atgtcccggt gctgacggcc acatggggac ctaacagtgc caaacgccat ctgctccagc   3180

tgctttttca cccagttgca gagtcctcac cactcccaca ttgatctgct gttttcaatt   3240

ggaaccattt ctcctgcctg aaactccagg gcccctccct gggctgtccg tgagcaggag   3300

accccacccc agcagcagtg gtgagcaggc ctgtgcctcc acgcccagcc cccgccaacg   3360

cgactggttt tgtttgccac acggtgagaa ccggaggacg ggatgctcca gccagttggg   3420

tggttctggg gtccctgagg aagccccctc ctgcacttcc attaagacag ccagtggttc   3480

ctggatcttt gtcaccaagc agcgttgagc cagagctgtc taatgctgag cccagctcag   3540

gaaggagaga ggagtccttc agtgtgtctt ggagatgcga agtgcgtcct cgtaaaggtc   3600

agctgtcagt tttgctggcc gctccggcgc tggctctcct gtccgggacc acaacgagaa   3660

acagcgacag attcgacgca gagctccgga agtgcctgag gagcagtggt tcttggaaat   3720

cgcccgtcct ccgcatcaca gcctctcacc agcaaagcag cctctgccca ggccctggcg   3780

ggagagctgc agagggaccc aggtgcctgg agggcatttg agggaggtgg ctggacaggt   3840

gtctccctga agaagaaggg agaacacttt tcaaagtgat tccgaggcag tgcgggagga   3900

cacacgtgct gtgcagtgga gtggggtcgc ccgtggcccc catcagagtc cccgtccccc   3960

aggacaagtg cagaacctct gtgggccccc tccttccacc tagatagaga aaaccccttg   4020

ttcggtttcc ttcccgtgtc ccgttgtttt tctaagcccc ccgaattgag tcgtttctat   4080

ggcactaacc tttccatggg aaataagctc tttgtggaag tccgtacctg ttgccctggg   4140

tgaggtttca gagaaacggg ggcaggatga acacagccgg ctgtcctggg tgcagttacg   4200

tccgtggagg gtgagagatt gcgccccgtt ccacacttgt gtcgcctgct gttgtctgtg   4260

ggccttttct ttccgtggtg cctggtgtgt gcgtgcatgg cgtgagagaa cggggggtgg   4320

gggttggagg tggctccccg acaccggtgc ctgtgtggcc tgagccggcg ccctcccggg   4380

agcgcccgtc acggggggcc tctgtgatta cctgctgctg ctctctcccg cgtggtgact   4440

atatgtcctc agggctgcct gtggccaccc tgatgggaga cctctgtttg cttctgggcc   4500

actgcaggtt ggcctcctca atacaagctg atgtctgcag ggagcgccgc gtgctgggat   4560

tgcaccacgt gttggtcaca aatcgaggtc gccttttggc ctggtctgct caggctggcc   4620

ctgacccacg tggtttcctg gcttctgaga cgcagcgcat tcttcctgtt agcggtagcg   4680

ttctctgatt tcactgcttc attgccaagg gcgtggaaag ggggtggtgg atggagccgg   4740

gaggtggcga gcacaggacc ccggggctgc attctgccgt gtggggttct gcactgtcta   4800

gcttctgcgg ggactgcaaa gagggatgaa gggacgtggt cctaggggtc ggctcagact   4860

cggagcaggg cagggagagg agggcaagga gaggaggcct gggtcctgga tccactgctc   4920

tgggctcata accatgagat tttgaaagag tttttggtca tctgagcagg taccatgcct   4980

ggctcatgcc ggaacttgtc ttggaaccgg tagccagagg cccaggaagg gacagggccc   5040

aaaagggttg catgtcccgg ccacaaagcc ctccctgtgt gccctgagcc agcccagcaa   5100

gcgcctccca gccaggcgct ttcgcagaag caagagcaca ggccaggggg accgggagag   5160

cctcagcccc cagcctgggc ggcctgtgac cctgagccgt gtggagccag gacccaagaa   5220

ccttctctag gttctcaagg gtgagctgac ccgggcaatg tgcaggaatg tggggagcaa   5280

aagtagctga ttccagcccc gttctggggt cactggggag gcagaggctg agggcctgtt   5340

ctctggtcac cagggactgg gggcacggtc cacagcggat gagaacagca ggtcacagta   5400

gtggctttgg gaagggcccc tcctgctttg ccctgttcgg aaaggggctc cctcagagcc   5460

cctgggccca gtaacccgct tctgtctcct gactcctgct ggataaattg ccaggtttat   5520

caaatacaag aaaacacctg ctttggctag gaggtaagtc ccaaaaagaa cgtcttaagt   5580

agagcaaagg catccaccga ggccatttgg tggcccctgg gaagtgggga agcagggcct   5640

gagcgtcccc aggctgctag ggcagcagct ggctcagggc acactctctc gtgccagctt   5700

ctgccaccag cccagtgtcc acggagccgc ggggccagag gagctcaggg agacctggct   5760

gtctagggca tggtacccag tatcccggtg tgtgcccatc ctcagccact tgtgtctttc   5820

tttccatgtg ggagttctcc cggtgacacc tgccctccgt tgagggtgga atctgtcact   5880

catgcctttg agggacccag atggaccatc cctcttctgc ttgctttcta cattcctaaa   5940

aacctcaacg ttaatccctc accagtcggg ccgagtgtgg cctcatggtt ctgccgcggc   6000

ccagtcttct cccactggct tcacgctaga gggcgccatg cgctctgggt gaaatgagac   6060

gctggtgtgg ggtccccatg tagagaccct caggtcccta tccagagacc ctccaggcag   6120

tgctgggaag acactggtgg cggggaccat gaccaggcgg gtggagccat gtgtgtctca   6180

cacctgccgc ccctcacttt ccttcccgag gtctggtagg tcctctttgg gatttgctgt   6240

ttatttgtat ctcccttttc tttgatttaa gaacaatgcc aagtgaaaaa gctgggaatg   6300

aatttctgag ttgctgagtg ttccctgctc ctaggtacca cgctctgtgc ttctcaggca   6360

gggaggagat ggattcggtg gagttgggcc aggacggggg cttcaccctg ccccctccag   6420

actgccgaag cccccaagaa gttttgagcc cagctgggcc tcgcctcccc ggctcctggg   6480

tccattttct gtactggttt gagatcacag gcatcattca gcgaatgctc ttgtgtcctc   6540

tgcataaaga gggccctccc tggagcaccc ccggggagct gggactctcc agaaagcccc   6600

gggtgagggc tccgtcttga gagagagaga aatcccttct ttgggcgatt cagtgagttc   6660

aggaggagga ggaagctttt ccttggcttt gaaatcagtg tttttatgga gacaaagaac   6720

agacctcagt gggaaaaatg aaaacgtaat ggaacacggg gaggtgtcgg agaagaaagg   6780

attttcccct tcgctttcag agccggcggg agtgcaggtc tgttttgctt cagaagcctc   6840

acattctgct ttgcccttga gtgacttcat gcgggatgag gaactgttga cccctctaga   6900

gaggacaccc caagtccatc ctgggctcct cctcacccct ctgagaaagc ccccctaaaa   6960

aaaggcttca gagtcaccgg catgccgcct cacgttgcag gacggaatcg cgcgctcctc   7020

acgctggagt aagttacgaa acatgatcgt caggctcttt gcaaacgcag agccccagaa   7080

cgctggatgg aggcctcctc ggccctgcgg gcggcctggc tgcggtaggt ctgctgcaag   7140

gagccaccac ggggactgcg ccacactcct gatgaaaacg tgtttaccca cagcctcgcc   7200

tcgagcctcc ttgacaatac cgctgcttca aagcaatatt atttaatgag aatactttac   7260

attgctcaca tgtgctgcta tgaagacagg attagtctgt agacgggact cagctccaga   7320

ggttcctggg taatgtattg tggctcttgg aaatgagggt agaatttgaa atataacaaa   7380

tggtctctcg cccggttctg tcccttattt ttagattgtt ttcctgcatc ttacaatttc   7440

cttttctttt caaagttcct ttctccaggc ctgtttttca gtgctcagga cacggttttc   7500

atcacatact tactgttttt ttggttgggt tttgatacga aaagctgcta cgtttggtga   7560

ccagagggag ggtttggaat ctgtgctttg caggggatct cggtgggtac cgcggcccct   7620

cgcagggtgg cgagtggggt ccgtgcctcg agaagggggc ccttacccac accgtgcggc   7680

ttgaattctg tcggagttga atctgtggaa aggattgtcc cattagagct gctgcgtcct   7740

ttcctctgtc ctccctgtca cccaaacccc gaagtcacag ctgcttagaa gaatgggatt   7800

ttggggatac aaccacacac atttccctct ggactgaaat tttaaaaaca gacccatttc   7860

actgacttct tttttttttt tttttttttt ttttttttga gacggagtct cgctctgtcg   7920

cccaggctgg agtgcagtgg cgtgatctcg gctcactgca agctccgcct cccgggttca   7980

cgccattctc ctgcctcagc ctcccgagta gctgggacta caggcgcccg ctaccacgcc   8040

cggctaattt tttgtatttt tagtagagac ggggtttcac cgtgttagcc aggatggtct   8100

cgatctcctg acctcgtgat ccgcccgcct cggcctccca aagtgctggg attacaggcg   8160

tgagccaccg cgcccggccc actgacttct ttagggaaaa tagtttcagt cttgggttgt   8220

cttgtgagcc cacgggcatg ggaccctgtc tctgctgggc ttttccggcc ccgtcccagc   8280

tcctcctcag gcagaggctg cagccctcag ctctgctgct ggatggaaca tttcaacccc   8340

ctccgggaag gtgggcaggg tggagggccc agggctaggc ctgccatgca ccatgagcag   8400

gggtgctacc tgggtgtgtg aagttgggct ggcttttcct ggaggtgggt gagaaggctc   8460

tccgggcaaa tcagaaggcc acgagagaga gaggagcggg gagagtggtg aggaggattc   8520

gtctctgact gatgaacctc gccgtgcctg tctgtcacat ccaagtctgt gccagctgct   8580

gggaggtcag actcctgccc tgagaaacag cccagtcctt ggagaatgaa accctgaggg   8640

tcagtgagtg gaggccttcc ctcggggcca gccattcccg ggaggcctga gtgtgacctg   8700

gaagctctgt gggtcaccaa gactggcatt ttccttgtat ttttgtgcag ggctgaagtg   8760

agcgttcctc ctctgaattg gtgaggcttt ggaaattttt tgtttcttct actcatccta   8820

atggctggtt ttggctgccc ggagtatcag agaatatcac taagagggca gtcagtttat   8880

ttttaggcat ctttctttct gtccagggag aaacccctcg gaagaatctt agtcactctt   8940

tgcacctgcc ctgtcattct cgccatgggg aaaatgcgtt gaaaagaaaa ataccggggc   9000

cagggagaag ccgtgaatgt atttatttgc tttggtgaag ctgctgaaca ctggctgcgg   9060

agggcccccc gcccccatcc cgcttcaggc cccagtgacc cagttgcgtc ttaagttcca   9120

tcgtccagat ttcaggccac cagaggctgc caaaggtgac tgaagcggtc tccaagtcac   9180

tctgtcacca cttttttttt ttttgagatg gagtctcgct ctatcgccca ggctggagtg   9240

cagtggccca atctcggctc actgcaacct ccgcctccca ggttcgagcg aattctcctg   9300

cctcaacctc ccaagtagct gggattacag gcacctgcca ccacacccgg ctaatttttg   9360

tatttctaat agagatgaga gtgttaccat gttggtcagg ctggtcttga actcctgacc   9420

tcaggtgatc tgcccacctc aacctcccaa agtgctggga ttataggcat gagccaccgc   9480

gcctggcctc tgtcactttt tttgctcctt acccagtttt tgttttttgt tgttttgttt   9540

tgttttagcg tgatactaca atggaaagac tcctagttgg ttattcttta tctcggattc   9600

ttttttctgg aattgtttgc tcatttgagt ggttggtggt ttgccctgtg tcagacacgg   9660

tgaaaagagt gcaggaaagc tggggccagg ggaagcgaag tggcttcaat ccgggctgac   9720

agccaagaag agttttcctc ccttcggtga cagggcctgc ccctccgagt ctagaggtaa   9780

aagcagcttc tagaactggc ccctaagtct ccaaatgtgt tggctaagct gaaatgagag   9840

actctgaatt agagtttttg tttgtttgtt tgttctctgc atgaagttca caggcctgta   9900

tggatgttaa attgtgtcta tagcctctaa atctccaggt taactggtcc agattttttt   9960

tttttaatca gtaacaatgg gaatttaaaa tcaaatattt ggccaggtgc ggtggctcat  10020

gcccgtaatc ccagcacttt gggaggccga ggcaggcgca tcacctgagg agtttgagac  10080

cagcctgacc aacatggtga aatcctgtct ctactaaaaa tacaaaaaat tagccaggcg  10140

tggtggcgtg tgcctgtaat cccagctacc agggaggctg aggcatgaga atcgcttgaa  10200

cctgggagat ggaggttgca gtgagccgag atcatgccac tgcactccag cctgggcaac  10260

agagggagac tctgtctcaa aaataataat caaatcaagt attttaagtt tggctcttct  10320

ttttttcaag aaaggctttt tggataccta gaataccttc atgtatgtgg cttgatttct  10380

gtttcaggaa aaggggggcg ggaggagaga caacagccgt gttccagagt ctgtcctgag  10440

atgtcgctga gtccagacac ttgggctgca cgtgccctgc agatgacaaa ggccggcagc  10500

tcagcacacg tgcaggaggg gttaaagcca atattgagtt tttgttcttg ttgttttaat  10560

ctgaacgatt attctcctgt aaaaataatt tgggaggggc gggtgttgtt cggtgtgtgt  10620

gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt attttttttt ttacagtggc gcctgtctaa  10680

agtatttttc acaacatgtt tgataatcag tgctttaaaa agcagcagtg tcctatgaag  10740

tggaaatgtc agttctagag cattggatgt gaagttctgg tcatgtcacc ttgcgtgtct  10800

caccctggag gagtgaaggt gggcgcccgg cgggggggtg tggctgcacc ccagcaccgg  10860

gagggggcac gcacgacacc agaggaaggg acagccccac ccatgtcaac agcaggcaac  10920

ctgtgttttc atttcaagtg ggatacagta tttttttaat aaggagccat actttttttt  10980

aagagtttga gatctgaatg tgatttctaa ttgtatcaga cgttaatgtt ttaaagctat  11040

aacaaagttt aaaatttcta ctttttgttt ttcatttatt ttaactgttc ttttatctat  11100

taaattgttg tatgtggatg gggaagtttt gtttctcctc ttagcatttg tttctataac  11160

cagaaataaa attctatatt aaagaaatga c                                 11191


<210>  395
<211>  733
<212>  PRT
<213>  Homo sapiens

<400>  395

Met Ala Glu Val Gly Glu Asp Ser Gly Ala Arg Ala Leu Leu Ala Leu 
1               5                   10                  15


Arg Ser Ala Pro Cys Ser Pro Val Leu Cys Ala Ala Ala Ala Ala Ala 
            20                  25                  30


Ala Phe Pro Ala Ala Ala Pro Pro Pro Ala Pro Ala Gln Pro Gln Pro 
        35                  40                  45


Pro Pro Gly Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Pro Gly Ala 
    50                  55                  60


Ile Ala Gly Ala Gly Ser Ser Gly Gly Ser Ser Gly Val Ser Gly Asp 
65                  70                  75                  80


Ser Ala Val Ala Gly Ala Ala Pro Ala Leu Val Ala Ala Ala Ala Ala 
                85                  90                  95


Ser Val Arg Gln Ser Pro Gly Pro Ala Leu Ala Arg Leu Glu Gly Arg 
            100                 105                 110


Glu Phe Glu Phe Leu Met Arg Gln Pro Ser Val Thr Ile Gly Arg Asn 
        115                 120                 125


Ser Ser Gln Gly Ser Val Asp Leu Ser Met Gly Leu Ser Ser Phe Ile 
    130                 135                 140


Ser Arg Arg His Leu Gln Leu Ser Phe Gln Glu Pro His Phe Tyr Leu 
145                 150                 155                 160


Arg Cys Leu Gly Lys Asn Gly Val Phe Val Asp Gly Ala Phe Gln Arg 
                165                 170                 175


Arg Gly Ala Pro Ala Leu Gln Leu Pro Lys Gln Cys Thr Phe Arg Phe 
            180                 185                 190


Pro Ser Thr Ala Ile Lys Ile Gln Phe Thr Ser Leu Tyr His Lys Glu 
        195                 200                 205


Glu Ala Pro Ala Ser Pro Leu Arg Pro Leu Tyr Pro Gln Ile Ser Pro 
    210                 215                 220


Leu Lys Ile His Ile Pro Glu Pro Asp Leu Arg Ser Met Val Ser Pro 
225                 230                 235                 240


Val Pro Ser Pro Thr Gly Thr Ile Ser Val Pro Asn Ser Cys Pro Ala 
                245                 250                 255


Ser Pro Arg Gly Ala Gly Ser Ser Ser Tyr Arg Phe Val Gln Asn Val 
            260                 265                 270


Thr Ser Asp Leu Gln Leu Ala Ala Glu Phe Ala Ala Lys Ala Ala Ser 
        275                 280                 285


Glu Gln Gln Ala Asp Thr Ser Gly Gly Asp Ser Pro Lys Asp Glu Ser 
    290                 295                 300


Lys Pro Pro Phe Ser Tyr Ala Gln Leu Ile Val Gln Ala Ile Ser Ser 
305                 310                 315                 320


Ala Gln Asp Arg Gln Leu Thr Leu Ser Gly Ile Tyr Ala His Ile Thr 
                325                 330                 335


Lys His Tyr Pro Tyr Tyr Arg Thr Ala Asp Lys Gly Trp Gln Asn Ser 
            340                 345                 350


Ile Arg His Asn Leu Ser Leu Asn Arg Tyr Phe Ile Lys Val Pro Arg 
        355                 360                 365


Ser Gln Glu Glu Pro Gly Lys Gly Ser Phe Trp Arg Ile Asp Pro Ala 
    370                 375                 380


Ser Glu Ala Lys Leu Val Glu Gln Ala Phe Arg Lys Arg Arg Gln Arg 
385                 390                 395                 400


Gly Val Ser Cys Phe Arg Thr Pro Phe Gly Pro Leu Ser Ser Arg Ser 
                405                 410                 415


Ala Pro Ala Ser Pro Thr His Pro Gly Leu Met Ser Pro Arg Ser Gly 
            420                 425                 430


Gly Leu Gln Thr Pro Glu Cys Leu Ser Arg Glu Gly Ser Pro Ile Pro 
        435                 440                 445


His Asp Pro Glu Phe Gly Ser Lys Leu Ala Ser Val Pro Glu Tyr Arg 
    450                 455                 460


Tyr Ser Gln Ser Ala Pro Gly Ser Pro Val Ser Ala Gln Pro Val Ile 
465                 470                 475                 480


Met Ala Val Pro Pro Arg Pro Ser Ser Leu Val Ala Lys Pro Val Ala 
                485                 490                 495


Tyr Met Pro Ala Ser Ile Val Thr Ser Gln Gln Pro Ala Gly His Ala 
            500                 505                 510


Ile His Val Val Gln Gln Ala Pro Thr Val Thr Met Val Arg Val Val 
        515                 520                 525


Thr Thr Ser Ala Asn Ser Ala Asn Gly Tyr Ile Leu Thr Ser Gln Gly 
    530                 535                 540


Ala Ala Gly Gly Ser His Asp Ala Ala Gly Ala Ala Val Leu Asp Leu 
545                 550                 555                 560


Gly Ser Glu Ala Arg Gly Leu Glu Glu Lys Pro Thr Ile Ala Phe Ala 
                565                 570                 575


Thr Ile Pro Ala Ala Gly Gly Val Ile Gln Thr Val Ala Ser Gln Met 
            580                 585                 590


Ala Pro Gly Val Pro Gly His Thr Val Thr Ile Leu Gln Pro Ala Thr 
        595                 600                 605


Pro Val Thr Leu Gly Gln His His Leu Pro Val Arg Ala Val Thr Gln 
    610                 615                 620


Asn Gly Lys His Ala Val Pro Thr Asn Ser Leu Ala Gly Asn Ala Tyr 
625                 630                 635                 640


Ala Leu Thr Ser Pro Leu Gln Leu Leu Ala Thr Gln Ala Ser Ser Ser 
                645                 650                 655


Ala Pro Val Val Val Thr Arg Val Cys Glu Val Gly Pro Lys Glu Pro 
            660                 665                 670


Ala Ala Ala Val Ala Ala Thr Ala Thr Thr Thr Pro Ala Thr Ala Thr 
        675                 680                 685


Thr Ala Ser Ala Ser Ala Ser Ser Thr Gly Glu Pro Glu Val Lys Arg 
    690                 695                 700


Ser Arg Val Glu Glu Pro Ser Gly Ala Val Thr Thr Pro Ala Gly Val 
705                 710                 715                 720


Ile Ala Ala Ala Gly Pro Gln Gly Pro Gly Thr Gly Glu 
                725                 730


<210>  396
<211>  2890
<212>  DNA
<213>  Homo sapiens

<400>  396
cggaagttga ccggggtgcg gagctcctgg gctgcagctc ctggagtttc cgaggttcgt     60

gcgcgtctgg tggcggcggc gtgatgttct cggcaggagc ggagagtttg ctccaccagg    120

ccagggagat ccaggacgag gagctgaaga agttctgttc ccggatctgt aaactgctgc    180

aggcggagga cttggggccg gacaccctcg actccctgca gaggctcttc ctcatcatct    240

cagccacgaa gtacagccgg aggctggaga agacatgcgt agacctgctg caggccaccc    300

tcggcctgcc tgcatgcccc gagcagctcc aggtgctttg cgccgccatc ctgcgagaga    360

tgtccccctc tgacagcctc agcctggcct gggaccacac gcagaacagc cggcagctga    420

gcctggtggc ctccgttctc ttggcccagg gtgacagaaa cgaggaggtc agagccgtgg    480

gccagggcgt gctacgagcg ctggagagcc ggcagcctga gggacccagc ctcagacacc    540

tcctccccgt catggccaag gtcgtggtcc tcagcccggg caccctccag gaggaccagg    600

ccaccctgct cagcaagcgg ctggtcgact ggctgcgcta cgccagcctc cagcaagggc    660

tcccacactc cggcggcttc ttctccacgc ccagggcccg gcagccgggc cccgtcaccg    720

aggtggacgg ggcggtagcc acagacttct tcacggtgct ctccagcggc caccgcttca    780

cagacgacca gtggctgaac gtgcaggcct tctctatgct gcgggcgtgg ctgctgcaca    840

gcggccccga gggcccgggc accctggaca cagatgacag gtcagagcag gagggctcca    900

ctctgtcggt gatctccgcc acctcctctg ccggccgcct gctgccgccc cgggagcggc    960

ttcgggaggt ggccttcgag tactgccagc gcctcattga gcaaagtaac cgacgagccc   1020

tgaggaaggg ggactccgac ctgcagaaag cttgcctggt ggaggccgtg ctggtgctgg   1080

acgtgctgtg ccggcaggac ccgtccttcc tgtaccgaag tctctcctgc ctgaaggccc   1140

tgcacgggcg ggtgcgcggg gacccggcct ctgtgcgggt gctgctgccc ctcgcccact   1200

tcttcctgag ccacggggaa gcggctgcag tggactcgga agccgtctac cagcacctgt   1260

tcaccaggat cccggtggag cagttccaca gccccatgct ggcctttgaa ttcatccagt   1320

tctgcaggga caacctccac ctgttcagcg ggcacctcag caccctcaga ttgagcttcc   1380

ccaacctctt taagttcctg gcctggaaca gcccacccct cacctccgag tttgtggcgc   1440

tcctcccggc cctggtggac gctggcacag ccctggagat gctgcacgcg ctgctggacc   1500

tgccctgctt gacggcggtg ctggacctgc agctcaggtc agcaccggct gcatccgaga   1560

ggccactctg ggacacctct ctcagggccc ccagctgcct ggaggccttc cgggacccgc   1620

agttccaggg tcttttccaa tacctgctgc gccccaaggc cagtggcgcc actgagaggt   1680

tggcgccact ccaccagctg ctgcagccca tggccggctg tgcccgcgtg gcccagtgtg   1740

cccaggccgt gcccacgctg ctgcaggcat tcttctcagc agtgacccag gtggctgacg   1800

ggtccctgat caaccagctg gcgctgctgc tcctgggcag gagcgactcg ctctacccgg   1860

ccccagggta cgctgccggt gtgcacagtg tgctgagttc tcagttcctg gccctgtgta   1920

cgctgaaacc ctccctggtg gtggagctgg caagagacct gctggagttc ctgggcagcg   1980

tgaatggtct ctgcagcagg gcgagcctcg tcaccagcgt ggtgtgggcc atcggcgagt   2040

acctgtcggt gacctacgat cggaggtgca ccgtggagca gatcaacaag ttcttcgaag   2100

ccctggaggc tctgctattc gaggtcaccc agtgccgccc ctctgctgcc ctgcccaggt   2160

gtccccccca ggtggtcacc gtgctgatga ccacgctgac gaagctggcc tcccggagcc   2220

aagatctgat ccccagggcc tctttattgc tgtcaaagat gaggaccctg gctcacagtc   2280

cagccaccag ctccacgcac agcgaggagg gcgcggaagc catccgtacc cgggccacag   2340

agctgctgac cctgctgaag atgcctagcg tggcccagtt tgtgctcaca cccagcacgg   2400

aggtgtgcag cccccgctat caccgcgatg ccaacacggc cctgcccctg gccctgcgca   2460

cggtcagccg gctggtggag agggaggccg gcctcatgcc agggtgaagg gacagtggcc   2520

agggacttcg gtgcagatta agagcctggg cagccagctt gctactgagg ccaggctgat   2580

aggagctcag gagggcgcgg gagtcctggg agaggaggca aggcccacgg tgggcttggc   2640

accctcacag acacgcgggg ctggcccccc tgctcaccct ctgggctttg tctccgagcc   2700

ttttgctccc aggcaacact gagctgagct gaggggtgcc atggagcggc tctgattgga   2760

ggcttgaggc cctgtggctg ggtcgggtgg aggctgctgg gtctgtttcc tagtcttttg   2820

tttttggaca gttgatgggc aagaagagct gcagtaaaag taaatctcct ttaataagcg   2880

tctgtatgaa                                                          2890


<210>  397
<211>  807
<212>  PRT
<213>  Homo sapiens

<400>  397

Met Phe Ser Ala Gly Ala Glu Ser Leu Leu His Gln Ala Arg Glu Ile 
1               5                   10                  15


Gln Asp Glu Glu Leu Lys Lys Phe Cys Ser Arg Ile Cys Lys Leu Leu 
            20                  25                  30


Gln Ala Glu Asp Leu Gly Pro Asp Thr Leu Asp Ser Leu Gln Arg Leu 
        35                  40                  45


Phe Leu Ile Ile Ser Ala Thr Lys Tyr Ser Arg Arg Leu Glu Lys Thr 
    50                  55                  60


Cys Val Asp Leu Leu Gln Ala Thr Leu Gly Leu Pro Ala Cys Pro Glu 
65                  70                  75                  80


Gln Leu Gln Val Leu Cys Ala Ala Ile Leu Arg Glu Met Ser Pro Ser 
                85                  90                  95


Asp Ser Leu Ser Leu Ala Trp Asp His Thr Gln Asn Ser Arg Gln Leu 
            100                 105                 110


Ser Leu Val Ala Ser Val Leu Leu Ala Gln Gly Asp Arg Asn Glu Glu 
        115                 120                 125


Val Arg Ala Val Gly Gln Gly Val Leu Arg Ala Leu Glu Ser Arg Gln 
    130                 135                 140


Pro Glu Gly Pro Ser Leu Arg His Leu Leu Pro Val Met Ala Lys Val 
145                 150                 155                 160


Val Val Leu Ser Pro Gly Thr Leu Gln Glu Asp Gln Ala Thr Leu Leu 
                165                 170                 175


Ser Lys Arg Leu Val Asp Trp Leu Arg Tyr Ala Ser Leu Gln Gln Gly 
            180                 185                 190


Leu Pro His Ser Gly Gly Phe Phe Ser Thr Pro Arg Ala Arg Gln Pro 
        195                 200                 205


Gly Pro Val Thr Glu Val Asp Gly Ala Val Ala Thr Asp Phe Phe Thr 
    210                 215                 220


Val Leu Ser Ser Gly His Arg Phe Thr Asp Asp Gln Trp Leu Asn Val 
225                 230                 235                 240


Gln Ala Phe Ser Met Leu Arg Ala Trp Leu Leu His Ser Gly Pro Glu 
                245                 250                 255


Gly Pro Gly Thr Leu Asp Thr Asp Asp Arg Ser Glu Gln Glu Gly Ser 
            260                 265                 270


Thr Leu Ser Val Ile Ser Ala Thr Ser Ser Ala Gly Arg Leu Leu Pro 
        275                 280                 285


Pro Arg Glu Arg Leu Arg Glu Val Ala Phe Glu Tyr Cys Gln Arg Leu 
    290                 295                 300


Ile Glu Gln Ser Asn Arg Arg Ala Leu Arg Lys Gly Asp Ser Asp Leu 
305                 310                 315                 320


Gln Lys Ala Cys Leu Val Glu Ala Val Leu Val Leu Asp Val Leu Cys 
                325                 330                 335


Arg Gln Asp Pro Ser Phe Leu Tyr Arg Ser Leu Ser Cys Leu Lys Ala 
            340                 345                 350


Leu His Gly Arg Val Arg Gly Asp Pro Ala Ser Val Arg Val Leu Leu 
        355                 360                 365


Pro Leu Ala His Phe Phe Leu Ser His Gly Glu Ala Ala Ala Val Asp 
    370                 375                 380


Ser Glu Ala Val Tyr Gln His Leu Phe Thr Arg Ile Pro Val Glu Gln 
385                 390                 395                 400


Phe His Ser Pro Met Leu Ala Phe Glu Phe Ile Gln Phe Cys Arg Asp 
                405                 410                 415


Asn Leu His Leu Phe Ser Gly His Leu Ser Thr Leu Arg Leu Ser Phe 
            420                 425                 430


Pro Asn Leu Phe Lys Phe Leu Ala Trp Asn Ser Pro Pro Leu Thr Ser 
        435                 440                 445


Glu Phe Val Ala Leu Leu Pro Ala Leu Val Asp Ala Gly Thr Ala Leu 
    450                 455                 460


Glu Met Leu His Ala Leu Leu Asp Leu Pro Cys Leu Thr Ala Val Leu 
465                 470                 475                 480


Asp Leu Gln Leu Arg Ser Ala Pro Ala Ala Ser Glu Arg Pro Leu Trp 
                485                 490                 495


Asp Thr Ser Leu Arg Ala Pro Ser Cys Leu Glu Ala Phe Arg Asp Pro 
            500                 505                 510


Gln Phe Gln Gly Leu Phe Gln Tyr Leu Leu Arg Pro Lys Ala Ser Gly 
        515                 520                 525


Ala Thr Glu Arg Leu Ala Pro Leu His Gln Leu Leu Gln Pro Met Ala 
    530                 535                 540


Gly Cys Ala Arg Val Ala Gln Cys Ala Gln Ala Val Pro Thr Leu Leu 
545                 550                 555                 560


Gln Ala Phe Phe Ser Ala Val Thr Gln Val Ala Asp Gly Ser Leu Ile 
                565                 570                 575


Asn Gln Leu Ala Leu Leu Leu Leu Gly Arg Ser Asp Ser Leu Tyr Pro 
            580                 585                 590


Ala Pro Gly Tyr Ala Ala Gly Val His Ser Val Leu Ser Ser Gln Phe 
        595                 600                 605


Leu Ala Leu Cys Thr Leu Lys Pro Ser Leu Val Val Glu Leu Ala Arg 
    610                 615                 620


Asp Leu Leu Glu Phe Leu Gly Ser Val Asn Gly Leu Cys Ser Arg Ala 
625                 630                 635                 640


Ser Leu Val Thr Ser Val Val Trp Ala Ile Gly Glu Tyr Leu Ser Val 
                645                 650                 655


Thr Tyr Asp Arg Arg Cys Thr Val Glu Gln Ile Asn Lys Phe Phe Glu 
            660                 665                 670


Ala Leu Glu Ala Leu Leu Phe Glu Val Thr Gln Cys Arg Pro Ser Ala 
        675                 680                 685


Ala Leu Pro Arg Cys Pro Pro Gln Val Val Thr Val Leu Met Thr Thr 
    690                 695                 700


Leu Thr Lys Leu Ala Ser Arg Ser Gln Asp Leu Ile Pro Arg Ala Ser 
705                 710                 715                 720


Leu Leu Leu Ser Lys Met Arg Thr Leu Ala His Ser Pro Ala Thr Ser 
                725                 730                 735


Ser Thr His Ser Glu Glu Gly Ala Glu Ala Ile Arg Thr Arg Ala Thr 
            740                 745                 750


Glu Leu Leu Thr Leu Leu Lys Met Pro Ser Val Ala Gln Phe Val Leu 
        755                 760                 765


Thr Pro Ser Thr Glu Val Cys Ser Pro Arg Tyr His Arg Asp Ala Asn 
    770                 775                 780


Thr Ala Leu Pro Leu Ala Leu Arg Thr Val Ser Arg Leu Val Glu Arg 
785                 790                 795                 800


Glu Ala Gly Leu Met Pro Gly 
                805


<210>  398
<211>  823
<212>  DNA
<213>  Homo sapiens

<400>  398
gggtccttca ggtaggaggt cctgggtgac tttggaagtc cgtagtgtct cattgcagat     60

aatttttagc ttagggcctg gtggctaggt cggttctctc ctttccagtc ggagacctct    120

gccgcaaaca tgctccgcca gatcatcggt caggccaaga agcatccgag cttgatcccc    180

ctctttgtat ttattggaac tggagctact ggagcaacac tgtatctctt gcgtctggca    240

ttgttcaatc cagatgtttg ttgggacaga aataacccag agccctggaa caaactgggt    300

cccaatgatc aatacaagtt ctactcagtg aatgtggatt acagcaagct gaagaaggaa    360

cgtccagatt tctaaatgaa atgtttcact ataacgctgc tttagaatga aggtcttcca    420

gaagccacat ccgcacaatt ttccacttaa ccaggaaata tttctcctct aaatgcatga    480

aatcatgttg gagatctcta ttgtaatctc tattggagat tacaatgatt aaatcaataa    540

ataactgaaa cttgatatgt gtcacttttt tatgctgaaa gtatgctctg aactttagag    600

tataggaaat taactattag aatttaaaga atttcttgaa tttctgtagt ttgaaaatac    660

gactttaagc tgctttagta aaacacttcc attttgtgta tagactgttg gtaacttcac    720

tagagcatac ataacaactg gaactggaaa ttatacaaaa gtaaattggg aaggatactc    780

cagcatctga cactggcaaa atggaaacct ttgagtttct ctt                      823


<210>  399
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  399

Met Leu Arg Gln Ile Ile Gly Gln Ala Lys Lys His Pro Ser Leu Ile 
1               5                   10                  15


Pro Leu Phe Val Phe Ile Gly Thr Gly Ala Thr Gly Ala Thr Leu Tyr 
            20                  25                  30


Leu Leu Arg Leu Ala Leu Phe Asn Pro Asp Val Cys Trp Asp Arg Asn 
        35                  40                  45


Asn Pro Glu Pro Trp Asn Lys Leu Gly Pro Asn Asp Gln Tyr Lys Phe 
    50                  55                  60


Tyr Ser Val Asn Val Asp Tyr Ser Lys Leu Lys Lys Glu Arg Pro Asp 
65                  70                  75                  80


Phe 



<210>  400
<211>  3421
<212>  DNA
<213>  Homo sapiens

<400>  400
gtatccgggt cgctgctttc cctattgtct gaggcagccg ccctcgcgct gtgcaatttc     60

tggtctttcg ttgcttctgg tccaggctaa taaagttttt ctttctttaa ttttttttct    120

tctagtttta acgggagaaa ttaactcccc ggggccgccg ggttgactgc gctgcctggg    180

ccggaggtct tctccggcca gggagcgctg tgggaagggg ctcgagcggc cagggccagg    240

cgaggccggg ggggcggggg gttaggggac cgcggggcta ctcttgggag cgcccctgtc    300

cggctggctg cgcgccggtt ttaaatagca tctttcggac ttgtcttcgc ggccccagtc    360

cccgacctcg gcgctgcctg ggctcctgca gcctctccct aagtcttctc caaacgacca    420

cctcacggat tccttatgga tcgcagctcc aagaggaggc aggtgaagcc tttggcagct    480

tctctgctgg aagctcttga ttatgatagt tcagatgaca gtgattttaa agttggagat    540

gcctcagatt ctgaagggag tggtaatgga agtgaagatg cttcaaagga cagtggagaa    600

ggttcctgta gtgattctga agaaaatatt ttagaagaag aactgaatga agatattaaa    660

gtaaaagaag aacaacttaa aaattctgca gaggaagaag tactatcatc agaaaaacaa    720

ttaattaaaa tggaaaagaa ggaagaagaa gaaaatggag aaagacctag aaagaaaaag    780

gagaaagaga aggaaaaaga aaaggaaaag gagaaagaga aggaaagaga gaaggaaaaa    840

gaaaaagcaa cagtatctga gaatgtggct gcttctgctg ctgccaccac accagccaca    900

agtcctcctg ctgttaacac atccccttct gttcccacta cgacaaccgc tacagaggaa    960

caagtcagcg agccaaaaaa atggaacctt cgacgaaacc gaccacttct ggattttgtg   1020

tccatggaag agctgaatga catggatgac tatgacagtg aggatgacaa tgattggcga   1080

cctactgtag taaagagaaa agggagatct gcgtctcaga aagagggaag tgatggagac   1140

aatgaggatg atgaagatga gggaagcggg agtgatgaag acgagaatga tgaaggcaat   1200

gatgaagatc atagtagccc tgccagtgaa gggggttgca agaagaagaa gagtaaagtt   1260

cttagcagaa acagtgctga tgatgaggaa ctgaccaatg atagcctgac cctatctcaa   1320

agcaagagta atgaggactc gctgattctt gagaagagtc aaaactggag ctctcaaaaa   1380

atggaccata ttctgatttg ctgtgtttgt ctgggagata atagtgagga cgctgatgaa   1440

ataattcagt gtgacaattg tggcattaca gtccatgaag gttgttatgg agttgatgga   1500

gagagtgact ctattatgag ttcagcttct gaaaactcca ctgaaccttg gttttgtgat   1560

gcctgtaaat gtggtgtttc tcctagctgt gaactgtgtc ctaatcagga tggaattttc   1620

aaggagacag atgctggaag atgggttcat attgtttgtg ccctgtatgt tcctggagta   1680

gcctttggag atattgacaa attacgacca gtaacactaa cggaaatgaa ctattccaaa   1740

tatggtgcca aggagtgtag cttttgtgaa gaccctcgct ttgctagaac tggggtttgc   1800

attagctgtg atgcagggat gtgcagagcc tatttccatg tgacctgtgc tcaaaaggaa   1860

ggtctgcttt cagaggcagc ggcggaagag gatatagcag atccattctt tgcttattgt   1920

aagcaacatg cagataggtt agacagaaag tggaagagaa aaaactactt ggctctacag   1980

tcctattgta aaatgtcttt gcaagagaga gagaagcaac tatcaccaga agcacaggca   2040

aggatcaatg cccggcttca gcagtatcgt gccaaagcag aactagctcg atctaccaga   2100

ccccaggcct gggttccaag ggaaaaattg cccagaccac tcaccagcag tgcttcagct   2160

attcgtaaac ttatgcggaa agcagaactc atggggatca gtacagatat ctttccagtg   2220

gacaattcag atactagttc tagtgtggat ggaaggagaa aacataagca accagctctc   2280

actgcagatt ttgtgaatta ttattttgag agaaatatgc gcatgattca aattcaggaa   2340

aatatggctg aacaaaagaa tataaaagat aaattagaga atgaacaaga aaagcttcat   2400

gtagaatata ataagctatg tgaatcttta gaagaactac aaaacctgaa tggaaaactt   2460

cgaagtgaag gacaaggaat atgggcttta ctaggcagaa tcacagggca gaagttgaat   2520

ataccggcaa ttttgcgagc acccaaggag agaaaaccaa gtaaaaaaga aggaggcaca   2580

caaaagacat ctactcttcc tgcagtactt tatagttgtg ggatttgtaa gaagaaccat   2640

gatcagcatc ttcttttatt gtgtgatacc tgtaaactac attaccatct tggatgtctg   2700

gatcctcctc ttacaaggat gccaagaaag accaaaaaca gttattggca gtgctcggaa   2760

tgtgaccagg cagggagcag tgacatggaa gcagatatgg ccatggaaac cctaccagat   2820

ggaaccaaac gatcaaggag gcagattaag gaaccagtga aatttgttcc acaggatgtg   2880

ccaccagaac ccaagaagat tccgataaga aacacgagaa ccagaggacg aaaacgaagc   2940

ttcgttcctg aggaagaaaa acatgaggaa agagttccta gagagagaag acaaagacag   3000

tctgtgttgc aaaagaagcc caaggctgaa gatttaagaa ctgaatgtgc aacttgcaag   3060

ggaactggag acaatgaaaa tcttgtcagg tgtgatgaat gcagactctg ctaccatttt   3120

ggctgtttgg atcctccttt gaaaaagtct cctaaacaga caggctacgg atggatatgt   3180

caggaatgtg attcttcatc ttccaaggaa gatgaaaatg aagctgaaag aaaaaatata   3240

tctcaggagc tcaacatgga acagaaaaat ccaaagaaat aaaagatttt ctgtagtgtt   3300

tttgaaaagt ttgcagctta tgtaatagca gataaaattt ctaattgtaa aatgttaaat   3360

tgtaaaatct aatttgcaaa atgttctcaa taaagtcatt caaaatgaaa aaaaaaaaaa   3420

a                                                                   3421


<210>  401
<211>  948
<212>  PRT
<213>  Homo sapiens

<400>  401

Met Asp Arg Ser Ser Lys Arg Arg Gln Val Lys Pro Leu Ala Ala Ser 
1               5                   10                  15


Leu Leu Glu Ala Leu Asp Tyr Asp Ser Ser Asp Asp Ser Asp Phe Lys 
            20                  25                  30


Val Gly Asp Ala Ser Asp Ser Glu Gly Ser Gly Asn Gly Ser Glu Asp 
        35                  40                  45


Ala Ser Lys Asp Ser Gly Glu Gly Ser Cys Ser Asp Ser Glu Glu Asn 
    50                  55                  60


Ile Leu Glu Glu Glu Leu Asn Glu Asp Ile Lys Val Lys Glu Glu Gln 
65                  70                  75                  80


Leu Lys Asn Ser Ala Glu Glu Glu Val Leu Ser Ser Glu Lys Gln Leu 
                85                  90                  95


Ile Lys Met Glu Lys Lys Glu Glu Glu Glu Asn Gly Glu Arg Pro Arg 
            100                 105                 110


Lys Lys Lys Glu Lys Glu Lys Glu Lys Glu Lys Glu Lys Glu Lys Glu 
        115                 120                 125


Lys Glu Arg Glu Lys Glu Lys Glu Lys Ala Thr Val Ser Glu Asn Val 
    130                 135                 140


Ala Ala Ser Ala Ala Ala Thr Thr Pro Ala Thr Ser Pro Pro Ala Val 
145                 150                 155                 160


Asn Thr Ser Pro Ser Val Pro Thr Thr Thr Thr Ala Thr Glu Glu Gln 
                165                 170                 175


Val Ser Glu Pro Lys Lys Trp Asn Leu Arg Arg Asn Arg Pro Leu Leu 
            180                 185                 190


Asp Phe Val Ser Met Glu Glu Leu Asn Asp Met Asp Asp Tyr Asp Ser 
        195                 200                 205


Glu Asp Asp Asn Asp Trp Arg Pro Thr Val Val Lys Arg Lys Gly Arg 
    210                 215                 220


Ser Ala Ser Gln Lys Glu Gly Ser Asp Gly Asp Asn Glu Asp Asp Glu 
225                 230                 235                 240


Asp Glu Gly Ser Gly Ser Asp Glu Asp Glu Asn Asp Glu Gly Asn Asp 
                245                 250                 255


Glu Asp His Ser Ser Pro Ala Ser Glu Gly Gly Cys Lys Lys Lys Lys 
            260                 265                 270


Ser Lys Val Leu Ser Arg Asn Ser Ala Asp Asp Glu Glu Leu Thr Asn 
        275                 280                 285


Asp Ser Leu Thr Leu Ser Gln Ser Lys Ser Asn Glu Asp Ser Leu Ile 
    290                 295                 300


Leu Glu Lys Ser Gln Asn Trp Ser Ser Gln Lys Met Asp His Ile Leu 
305                 310                 315                 320


Ile Cys Cys Val Cys Leu Gly Asp Asn Ser Glu Asp Ala Asp Glu Ile 
                325                 330                 335


Ile Gln Cys Asp Asn Cys Gly Ile Thr Val His Glu Gly Cys Tyr Gly 
            340                 345                 350


Val Asp Gly Glu Ser Asp Ser Ile Met Ser Ser Ala Ser Glu Asn Ser 
        355                 360                 365


Thr Glu Pro Trp Phe Cys Asp Ala Cys Lys Cys Gly Val Ser Pro Ser 
    370                 375                 380


Cys Glu Leu Cys Pro Asn Gln Asp Gly Ile Phe Lys Glu Thr Asp Ala 
385                 390                 395                 400


Gly Arg Trp Val His Ile Val Cys Ala Leu Tyr Val Pro Gly Val Ala 
                405                 410                 415


Phe Gly Asp Ile Asp Lys Leu Arg Pro Val Thr Leu Thr Glu Met Asn 
            420                 425                 430


Tyr Ser Lys Tyr Gly Ala Lys Glu Cys Ser Phe Cys Glu Asp Pro Arg 
        435                 440                 445


Phe Ala Arg Thr Gly Val Cys Ile Ser Cys Asp Ala Gly Met Cys Arg 
    450                 455                 460


Ala Tyr Phe His Val Thr Cys Ala Gln Lys Glu Gly Leu Leu Ser Glu 
465                 470                 475                 480


Ala Ala Ala Glu Glu Asp Ile Ala Asp Pro Phe Phe Ala Tyr Cys Lys 
                485                 490                 495


Gln His Ala Asp Arg Leu Asp Arg Lys Trp Lys Arg Lys Asn Tyr Leu 
            500                 505                 510


Ala Leu Gln Ser Tyr Cys Lys Met Ser Leu Gln Glu Arg Glu Lys Gln 
        515                 520                 525


Leu Ser Pro Glu Ala Gln Ala Arg Ile Asn Ala Arg Leu Gln Gln Tyr 
    530                 535                 540


Arg Ala Lys Ala Glu Leu Ala Arg Ser Thr Arg Pro Gln Ala Trp Val 
545                 550                 555                 560


Pro Arg Glu Lys Leu Pro Arg Pro Leu Thr Ser Ser Ala Ser Ala Ile 
                565                 570                 575


Arg Lys Leu Met Arg Lys Ala Glu Leu Met Gly Ile Ser Thr Asp Ile 
            580                 585                 590


Phe Pro Val Asp Asn Ser Asp Thr Ser Ser Ser Val Asp Gly Arg Arg 
        595                 600                 605


Lys His Lys Gln Pro Ala Leu Thr Ala Asp Phe Val Asn Tyr Tyr Phe 
    610                 615                 620


Glu Arg Asn Met Arg Met Ile Gln Ile Gln Glu Asn Met Ala Glu Gln 
625                 630                 635                 640


Lys Asn Ile Lys Asp Lys Leu Glu Asn Glu Gln Glu Lys Leu His Val 
                645                 650                 655


Glu Tyr Asn Lys Leu Cys Glu Ser Leu Glu Glu Leu Gln Asn Leu Asn 
            660                 665                 670


Gly Lys Leu Arg Ser Glu Gly Gln Gly Ile Trp Ala Leu Leu Gly Arg 
        675                 680                 685


Ile Thr Gly Gln Lys Leu Asn Ile Pro Ala Ile Leu Arg Ala Pro Lys 
    690                 695                 700


Glu Arg Lys Pro Ser Lys Lys Glu Gly Gly Thr Gln Lys Thr Ser Thr 
705                 710                 715                 720


Leu Pro Ala Val Leu Tyr Ser Cys Gly Ile Cys Lys Lys Asn His Asp 
                725                 730                 735


Gln His Leu Leu Leu Leu Cys Asp Thr Cys Lys Leu His Tyr His Leu 
            740                 745                 750


Gly Cys Leu Asp Pro Pro Leu Thr Arg Met Pro Arg Lys Thr Lys Asn 
        755                 760                 765


Ser Tyr Trp Gln Cys Ser Glu Cys Asp Gln Ala Gly Ser Ser Asp Met 
    770                 775                 780


Glu Ala Asp Met Ala Met Glu Thr Leu Pro Asp Gly Thr Lys Arg Ser 
785                 790                 795                 800


Arg Arg Gln Ile Lys Glu Pro Val Lys Phe Val Pro Gln Asp Val Pro 
                805                 810                 815


Pro Glu Pro Lys Lys Ile Pro Ile Arg Asn Thr Arg Thr Arg Gly Arg 
            820                 825                 830


Lys Arg Ser Phe Val Pro Glu Glu Glu Lys His Glu Glu Arg Val Pro 
        835                 840                 845


Arg Glu Arg Arg Gln Arg Gln Ser Val Leu Gln Lys Lys Pro Lys Ala 
    850                 855                 860


Glu Asp Leu Arg Thr Glu Cys Ala Thr Cys Lys Gly Thr Gly Asp Asn 
865                 870                 875                 880


Glu Asn Leu Val Arg Cys Asp Glu Cys Arg Leu Cys Tyr His Phe Gly 
                885                 890                 895


Cys Leu Asp Pro Pro Leu Lys Lys Ser Pro Lys Gln Thr Gly Tyr Gly 
            900                 905                 910


Trp Ile Cys Gln Glu Cys Asp Ser Ser Ser Ser Lys Glu Asp Glu Asn 
        915                 920                 925


Glu Ala Glu Arg Lys Asn Ile Ser Gln Glu Leu Asn Met Glu Gln Lys 
    930                 935                 940


Asn Pro Lys Lys 
945


<210>  402
<211>  4259
<212>  DNA
<213>  Homo sapiens

<400>  402
gtatccgggt cgctgctttc cctattgtct gaggcagccg ccctcgcgct gtgcaatttc     60

tggtctttcg ttgcttctgg tccaggctaa taaagttttt ctttctttaa ttttttttct    120

tctagtttta acgggagaaa ttaactcccc ggggccgccg ggttgactgc gctgcctggg    180

ccggaggtct tctccggcca gggagcgctg tgggaagggg ctcgagcggc cagggccagg    240

cgaggccggg ggggcggggg gttaggggac cgcggggcta ctcttgggag cgcccctgtc    300

cggctggctg cgcgccggtt ttaaatagca tctttcggac ttgtcttcgc ggccccagtc    360

cccgacctcg gcgctgcctg ggctcctgca gcctctccct aagtcttctc caaacgacca    420

cctcacggat tccttatgga tcgcagctcc aagaggaggc aggtgaagcc tttggcagct    480

tctctgctgg aagctcttga ttatgatagt tcagatgaca gtgattttaa agttggagat    540

gcctcagatt ctgaagggag tggtaatgga agtgaagatg cttcaaagga cagtggagaa    600

ggttcctgta gtgattctga agaaaatatt ttagaagaag aactgaatga agatattaaa    660

gtaaaagaag aacaacttaa aaattctgca gaggaagaag tactatcatc agaaaaacaa    720

ttaattaaaa tggaaaagaa ggaagaagaa gaaaatggag aaagacctag aaagaaaaag    780

gagaaagaga aggaaaaaga aaaggaaaag gagaaagaga aggaaagaga gaaggaaaaa    840

gaaaaagcaa cagtatctga gaatgtggct gcttctgctg ctgccaccac accagccaca    900

agtcctcctg ctgttaacac atccccttct gttcccacta cgacaaccgc tacagaggaa    960

caagtcagcg agccaaaaaa atggaacctt cgacgaaacc gaccacttct ggattttgtg   1020

tccatggaag agctgaatga catggatgac tatgacagtg aggatgacaa tgattggcga   1080

cctactgtag taaagagaaa agggagatct gcgtctcaga aagagggaag tgatggagac   1140

aatgaggatg atgaagatga gggaagcggg agtgatgaag acgagaatga tgaaggcaat   1200

gatgaagatc atagtagccc tgccagtgaa gggggttgca agaagaagaa gagtaaagtt   1260

cttagcagaa acagtgctga tgatgaggaa ctgaccaatg atagcctgac cctatctcaa   1320

agcaagagta atgaggactc gctgattctt gagaagagtc aaaactggag ctctcaaaaa   1380

atggaccata ttctgatttg ctgtgtttgt ctgggagata atagtgagga cgctgatgaa   1440

ataattcagt gtgacaattg tggcattaca gtccatgaag gttgttatgg agttgatgga   1500

gagagtgact ctattatgag ttcagcttct gaaaactcca ctgaaccttg gttttgtgat   1560

gcctgtaaat gtggtgtttc tcctagctgt gaactgtgtc ctaatcagga tggaattttc   1620

aaggagacag atgctggaag atgggttcat attgtttgtg ccctgtatgt tcctggagta   1680

gcctttggag atattgacaa attacgacca gtaacactaa cggaaatgaa ctattccaaa   1740

tatggtgcca aggagtgtag cttttgtgaa gaccctcgct ttgctagaac tggggtttgc   1800

attagctgtg atgcagggat gtgcagagcc tatttccatg tgacctgtgc tcaaaaggaa   1860

ggtctgcttt cagaggcagc ggcggaagag gatatagcag atccattctt tgcttattgt   1920

aagcaacatg cagataggtt agacagaaag tggaagagaa aaaactactt ggctctacag   1980

tcctattgta aaatgtcttt gcaagagaga gagaagcaac tatcaccaga agcacaggca   2040

aggatcaatg cccggcttca gcagtatcgt gccaaagcag aactagctcg atctaccaga   2100

ccccaggcct gggttccaag ggaaaaattg cccagaccac tcaccagcag tgcttcagct   2160

attcgtaaac ttatgcggaa agcagaactc atggggatca gtacagatat ctttccagtg   2220

gacaattcag atactagttc tagtgtggat ggaaggagaa aacataagca accagctctc   2280

actgcagatt ttgtgaatta ttattttgag agaaatatgc gcatgattca aattcaggaa   2340

aatatggctg aacaaaagaa tataaaagat aaattagaga atgaacaaga aaagcttcat   2400

gtagaatata ataagctatg tgaatcttta gaagaactac aaaacctgaa tggaaaactt   2460

cgaagtgaag gacaaggaat atgggcttta ctaggcagaa tcacagggca gaagttgaat   2520

ataccggcaa ttttgcgagc acccaaggag agaaaaccaa gtaaaaaaga aggaggcaca   2580

caaaagacat ctactcttcc tgcagtactt tatagttgtg ggatttgtaa gaagaaccat   2640

gatcagcatc ttcttttatt gtgtgatacc tgtaaactac attaccatct tggatgtctg   2700

gatcctcctc ttacaaggat gccaagaaag accaaaaaca gttattggca gtgctcggaa   2760

tgtgaccagg cagggagcag tgacatggaa gcagatatgg ccatggaaac cctaccagat   2820

ggaaccaaac gatcaaggag gcagattaag gaaccagtga aatttgttcc acaggatgtg   2880

ccaccagaac ccaagaagat tccgataaga aacacgagaa ccagaggacg aaaacgaagc   2940

ttcgttcctg aggaagaaaa acatgaggaa agagttccta gagagagaag acaaagacag   3000

tctgtgttgc aaaagaagcc caaggctgaa gatttaagaa ctgaatgtgc aacttgcaag   3060

ggaactggag acaatgaaaa tcttgtcaga tacccttcat gagacccaac tctgccacag   3120

ctcatcctcg gaggcaatcc cggaaacctc ttttataagt gtgattttaa aaatgtggat   3180

taaactctcg atagagtaca taaagtaaag gagaacagct atattgtcct ttctataagc   3240

ttgtcactgc aaaaagttgc cttttgcttg tcaggtttgg atagaatata attgattggt   3300

ttgttacttg gactaacaag gcagtagatt tgcctgtgtg gaattttttt tcctattttt   3360

cttctttttg ctttttttgc acttatcaga aatatttgat gtgtgcattg ttgaaaaata   3420

ctggatacat gtcttgtcag aattgtcgta ttaagtaatg tctttccctc ttgcttcttt   3480

ggcaaatgtt gatacacagt gtttggactt actgaagagt tactgaagcc tgtgggactt   3540

aataaataca atatgctact ccctgttgtg attgaacaat acaaataaca aacaagaaag   3600

acaatgcatt ccattagtct gctattctgt ttccttcaac ttcatacata gattcatata   3660

tgaagtactg cattgtaaaa caactataga ctcatattaa atgttatttc tatttataat   3720

attcagcaaa agtgaaagac ttgtgaagca tatgacattc tatttttgac ttattagtcc   3780

tagtgtgaaa gcattaatat tattagcatg aaatttttac ttcagatttt aagctcatga   3840

ataaagatat atctgtgttg atctctagat atttttagta atacccaaat atattcagtc   3900

cttattgttt taatataagc tttctgtgtt cagtataatt ttatttttct caaccttaaa   3960

tatgaactta ggaaataagg agggaagtac aaagattatt gactatacaa cctaccagct   4020

gaaagaaaga tcttcatcaa catctgtatc tttccagagg tatacagaat taaaatttga   4080

tcttcaagct ttaatgatcc agttttaagt caacggcaga agtatgttga atatttcatc   4140

actcaatctt gaactgattt agaagagact ctttgctgaa attgaattgc acttatacat   4200

gtaaattgtc aacatgtaat ttggaatttt ctgattaata aatgtggttt tggacatct    4259


<210>  403
<211>  888
<212>  PRT
<213>  Homo sapiens

<400>  403

Met Asp Arg Ser Ser Lys Arg Arg Gln Val Lys Pro Leu Ala Ala Ser 
1               5                   10                  15


Leu Leu Glu Ala Leu Asp Tyr Asp Ser Ser Asp Asp Ser Asp Phe Lys 
            20                  25                  30


Val Gly Asp Ala Ser Asp Ser Glu Gly Ser Gly Asn Gly Ser Glu Asp 
        35                  40                  45


Ala Ser Lys Asp Ser Gly Glu Gly Ser Cys Ser Asp Ser Glu Glu Asn 
    50                  55                  60


Ile Leu Glu Glu Glu Leu Asn Glu Asp Ile Lys Val Lys Glu Glu Gln 
65                  70                  75                  80


Leu Lys Asn Ser Ala Glu Glu Glu Val Leu Ser Ser Glu Lys Gln Leu 
                85                  90                  95


Ile Lys Met Glu Lys Lys Glu Glu Glu Glu Asn Gly Glu Arg Pro Arg 
            100                 105                 110


Lys Lys Lys Glu Lys Glu Lys Glu Lys Glu Lys Glu Lys Glu Lys Glu 
        115                 120                 125


Lys Glu Arg Glu Lys Glu Lys Glu Lys Ala Thr Val Ser Glu Asn Val 
    130                 135                 140


Ala Ala Ser Ala Ala Ala Thr Thr Pro Ala Thr Ser Pro Pro Ala Val 
145                 150                 155                 160


Asn Thr Ser Pro Ser Val Pro Thr Thr Thr Thr Ala Thr Glu Glu Gln 
                165                 170                 175


Val Ser Glu Pro Lys Lys Trp Asn Leu Arg Arg Asn Arg Pro Leu Leu 
            180                 185                 190


Asp Phe Val Ser Met Glu Glu Leu Asn Asp Met Asp Asp Tyr Asp Ser 
        195                 200                 205


Glu Asp Asp Asn Asp Trp Arg Pro Thr Val Val Lys Arg Lys Gly Arg 
    210                 215                 220


Ser Ala Ser Gln Lys Glu Gly Ser Asp Gly Asp Asn Glu Asp Asp Glu 
225                 230                 235                 240


Asp Glu Gly Ser Gly Ser Asp Glu Asp Glu Asn Asp Glu Gly Asn Asp 
                245                 250                 255


Glu Asp His Ser Ser Pro Ala Ser Glu Gly Gly Cys Lys Lys Lys Lys 
            260                 265                 270


Ser Lys Val Leu Ser Arg Asn Ser Ala Asp Asp Glu Glu Leu Thr Asn 
        275                 280                 285


Asp Ser Leu Thr Leu Ser Gln Ser Lys Ser Asn Glu Asp Ser Leu Ile 
    290                 295                 300


Leu Glu Lys Ser Gln Asn Trp Ser Ser Gln Lys Met Asp His Ile Leu 
305                 310                 315                 320


Ile Cys Cys Val Cys Leu Gly Asp Asn Ser Glu Asp Ala Asp Glu Ile 
                325                 330                 335


Ile Gln Cys Asp Asn Cys Gly Ile Thr Val His Glu Gly Cys Tyr Gly 
            340                 345                 350


Val Asp Gly Glu Ser Asp Ser Ile Met Ser Ser Ala Ser Glu Asn Ser 
        355                 360                 365


Thr Glu Pro Trp Phe Cys Asp Ala Cys Lys Cys Gly Val Ser Pro Ser 
    370                 375                 380


Cys Glu Leu Cys Pro Asn Gln Asp Gly Ile Phe Lys Glu Thr Asp Ala 
385                 390                 395                 400


Gly Arg Trp Val His Ile Val Cys Ala Leu Tyr Val Pro Gly Val Ala 
                405                 410                 415


Phe Gly Asp Ile Asp Lys Leu Arg Pro Val Thr Leu Thr Glu Met Asn 
            420                 425                 430


Tyr Ser Lys Tyr Gly Ala Lys Glu Cys Ser Phe Cys Glu Asp Pro Arg 
        435                 440                 445


Phe Ala Arg Thr Gly Val Cys Ile Ser Cys Asp Ala Gly Met Cys Arg 
    450                 455                 460


Ala Tyr Phe His Val Thr Cys Ala Gln Lys Glu Gly Leu Leu Ser Glu 
465                 470                 475                 480


Ala Ala Ala Glu Glu Asp Ile Ala Asp Pro Phe Phe Ala Tyr Cys Lys 
                485                 490                 495


Gln His Ala Asp Arg Leu Asp Arg Lys Trp Lys Arg Lys Asn Tyr Leu 
            500                 505                 510


Ala Leu Gln Ser Tyr Cys Lys Met Ser Leu Gln Glu Arg Glu Lys Gln 
        515                 520                 525


Leu Ser Pro Glu Ala Gln Ala Arg Ile Asn Ala Arg Leu Gln Gln Tyr 
    530                 535                 540


Arg Ala Lys Ala Glu Leu Ala Arg Ser Thr Arg Pro Gln Ala Trp Val 
545                 550                 555                 560


Pro Arg Glu Lys Leu Pro Arg Pro Leu Thr Ser Ser Ala Ser Ala Ile 
                565                 570                 575


Arg Lys Leu Met Arg Lys Ala Glu Leu Met Gly Ile Ser Thr Asp Ile 
            580                 585                 590


Phe Pro Val Asp Asn Ser Asp Thr Ser Ser Ser Val Asp Gly Arg Arg 
        595                 600                 605


Lys His Lys Gln Pro Ala Leu Thr Ala Asp Phe Val Asn Tyr Tyr Phe 
    610                 615                 620


Glu Arg Asn Met Arg Met Ile Gln Ile Gln Glu Asn Met Ala Glu Gln 
625                 630                 635                 640


Lys Asn Ile Lys Asp Lys Leu Glu Asn Glu Gln Glu Lys Leu His Val 
                645                 650                 655


Glu Tyr Asn Lys Leu Cys Glu Ser Leu Glu Glu Leu Gln Asn Leu Asn 
            660                 665                 670


Gly Lys Leu Arg Ser Glu Gly Gln Gly Ile Trp Ala Leu Leu Gly Arg 
        675                 680                 685


Ile Thr Gly Gln Lys Leu Asn Ile Pro Ala Ile Leu Arg Ala Pro Lys 
    690                 695                 700


Glu Arg Lys Pro Ser Lys Lys Glu Gly Gly Thr Gln Lys Thr Ser Thr 
705                 710                 715                 720


Leu Pro Ala Val Leu Tyr Ser Cys Gly Ile Cys Lys Lys Asn His Asp 
                725                 730                 735


Gln His Leu Leu Leu Leu Cys Asp Thr Cys Lys Leu His Tyr His Leu 
            740                 745                 750


Gly Cys Leu Asp Pro Pro Leu Thr Arg Met Pro Arg Lys Thr Lys Asn 
        755                 760                 765


Ser Tyr Trp Gln Cys Ser Glu Cys Asp Gln Ala Gly Ser Ser Asp Met 
    770                 775                 780


Glu Ala Asp Met Ala Met Glu Thr Leu Pro Asp Gly Thr Lys Arg Ser 
785                 790                 795                 800


Arg Arg Gln Ile Lys Glu Pro Val Lys Phe Val Pro Gln Asp Val Pro 
                805                 810                 815


Pro Glu Pro Lys Lys Ile Pro Ile Arg Asn Thr Arg Thr Arg Gly Arg 
            820                 825                 830


Lys Arg Ser Phe Val Pro Glu Glu Glu Lys His Glu Glu Arg Val Pro 
        835                 840                 845


Arg Glu Arg Arg Gln Arg Gln Ser Val Leu Gln Lys Lys Pro Lys Ala 
    850                 855                 860


Glu Asp Leu Arg Thr Glu Cys Ala Thr Cys Lys Gly Thr Gly Asp Asn 
865                 870                 875                 880


Glu Asn Leu Val Arg Tyr Pro Ser 
                885


<210>  404
<211>  1956
<212>  DNA
<213>  Homo sapiens

<400>  404
agcagtagga tctcggtttc cagcccagtg caatttctgc tctatcccgc tgacctcatt     60

gttgaggtat gtccttatag cagtgtgaga accgactaat acagttcctt aggaagcccc    120

tgctgggtat ggatggggag tgaagcaagg tgggcccaga agctgccgct ggctgagaga    180

ccatgaagaa agtgtataga atctccacca tcaccagagg aagagagctt ggcaggaaag    240

ttacttccat gaatggatga gttgaagtga acagcgtctt gggcaaaact gaagggtagt    300

tagtcgggtt tgtctctggt gggctttcag ctccactccc tgcatcccat tcccacatcg    360

tgatggtccc ctcataggcc cagggctacc accttggagc ataggtgggg atcctccagc    420

cagggtcctt ccttcacagg gagtcagagc cctctgctcc ggaattgccc tgccccaggt    480

cggccatcta tcaaaagccc cactatcccc taaagaccca ccctcaagca gcagatgtgc    540

agcaagggag ccgcaaatgt cattcctgtg accccgaagc agtctagtgt gttacctctc    600

tcagggctgc tatgggctga attgcttttc cccaaaattt ctatgctgct tccctaaccc    660

ccagcgcctc agaatctaac tctggatagg acctgtgaat aagtgattaa gttaaaatgg    720

ggtcctgtgg atgggcccta acccaatctg actggtgtcc ttttaagaag aggaagagac    780

accagagatg tgcacactca gagacaagac acatgaggac acagagacaa ggcggctacc    840

tgcaagccag ggagaggggc ctcggggaag ccaaccctgc ctacgccttg atcttggact    900

tccagcctcc agaactccag aatctgagtg aaatgggtat aaatcatgag ctaggataca    960

gttcaattat tcctatgatg aaaagagctt tctccgcatg tgggactctc ggcctcatta   1020

tgagtggcat ctttgacaat ccagggccca ttaaaaacac cttgaagaaa gcattcacca   1080

tgctgtggag cttcacagtc tataccaggc tggaatcctt gagggtggca ttatcaaatg   1140

aggaaatggt tcctttcatt tttcatctga agactcagac agcaaacatg ttatctggcc   1200

ctataagcac cccgatgctt ctgtgaaacc caagcaagtt ctgcatcacc acgacagccg   1260

cggatgtcaa atcatcaaaa cagcagcaga ggaaggggtt tattcctcct ccaaatcttc   1320

agctggtttt atagggttac cagtttaaag tttctttgtt ttcagagcat cagacctccc   1380

atttgtagct gatagccatt tttcaaaggt ttctggctca cccaggaatt cattagggtg   1440

gacgagaaaa gaacagtgga tagaatagac cagcagggca atctaagccc cattccctgt   1500

ctctttacat tggttcttgg tccccgtgac tcatccaaac tcccttatat tcctatctgg   1560

aatgcgaaag ctggaaatac aagtgctctg taatcacagg cagtggtttt cttggagtct   1620

ggtgtgattt ctgtagcttg cagcaatatg tgggacacac ttgcactgaa gaatttaatg   1680

acttgtttta ctgctgtctg ccatcaatat ttatctatat taactgaaga aaggcattac   1740

tcgaaatggc atttcacacc tctgagcatt atacagtaat tctaaagtca tacgttgtac   1800

caaattctct gggcaaacac agagatacag tatgaatgga aagaatccaa gttgaagttt   1860

ttaaaacttg aattgtctgc agtaatctgg aaaaccaaag tcaaaatgac tcgaattgct   1920

atggctggga atgactggat taaaagcaat ggaaac                             1956


<210>  405
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  405

Met Gly Ser Cys Gly Trp Ala Leu Thr Gln Ser Asp Trp Cys Pro Phe 
1               5                   10                  15


Lys Lys Arg Lys Arg His Gln Arg Cys Ala His Ser Glu Thr Arg His 
            20                  25                  30


Met Arg Thr Gln Arg Gln Gly Gly Tyr Leu Gln Ala Arg Glu Arg Gly 
        35                  40                  45


Leu Gly Glu Ala Asn Pro Ala Tyr Ala Leu Ile Leu Asp Phe Gln Pro 
    50                  55                  60


Pro Glu Leu Gln Asn Leu Ser Glu Met Gly Ile Asn His Glu Leu Gly 
65                  70                  75                  80


Tyr Ser Ser Ile Ile Pro Met Met Lys Arg Ala Phe Ser Ala Cys Gly 
                85                  90                  95


Thr Leu Gly Leu Ile Met Ser Gly Ile Phe Asp Asn Pro Gly Pro Ile 
            100                 105                 110


Lys Asn Thr Leu Lys Lys Ala Phe Thr Met Leu Trp Ser Phe Thr Val 
        115                 120                 125


Tyr Thr Arg Leu Glu Ser Leu Arg Val Ala Leu Ser Asn Glu Glu Met 
    130                 135                 140


Val Pro Phe Ile Phe His Leu Lys Thr Gln Thr Ala Asn Met Leu Ser 
145                 150                 155                 160


Gly Pro Ile Ser Thr Pro Met Leu Leu 
                165


<210>  406
<211>  3984
<212>  DNA
<213>  Homo sapiens

<400>  406
ggaaaaccga ggaatacaca tgcgcagttg gacccctcag gcccttcgtg tcccttccca     60

cccatctccc cgccccggcc ctctgggcgg ggctgggccg acagtccagc tgcagctcgc    120

tggagattca gtgacttcct tgttgtgagc cccggcccgg cagtgtcccg actcgtagcc    180

ccgctgttct taatccgggc cgctagcctg agtctaggtc gcagccgcag ccccaccccg    240

tcggtcacct tttcagcgca ggtcctttcc ccgcacgccc tgcgctccct aacatgccca    300

accccagcag cacctcctct ccctaccccc tccctgagga aattaggaac ctgttggcag    360

atgttgaaac atttgtagca gatatactga aaggagaaaa tttatccaag aaagcaaagg    420

aaaagagaga atcccttatt aagaagataa aagatgtaaa gtctatctat cttcaggaat    480

ttcaagacaa aggtgatgca gaagatgggg aagaatatga tgaccctttt gctgggcctc    540

cagacactat ttcattagcc tcagaacgat atgataaaga cgatgaagcc ccctctgatg    600

gagcccagtt tcctccaatt gcagcacaag accttccttt tgttctaaag gctggctacc    660

ttgaaaaacg cagaaaagat cacagctttc tgggatttga atggcagaaa cggtggtgtg    720

ctctcagtaa aacggtattc tattattatg gaagtgataa agacaaacaa cagaaaggtg    780

aatttgcaat agatggctac agtgtcagaa tgaataacac tctaagaaag gatggaaaga    840

aagattgctg ttttgaaatc tctgctcctg ataaacgtat atatcagttt acagcagctt    900

ctcccaaaga tgctgaagaa tgggtacagc agctgaaatt tgtattgcaa gatatggaat    960

ctgatattat tcctgaggat tatgatgaga gaggagaatt atatgatgat gttgatcatc   1020

ctctaccaat aagcaatcca ctaacaagca gtcaaccaat agatgatgaa atttatgaag   1080

aacttccaga agaagaagag gacagtgctc cagtgaaagt ggaagaacaa aggaagatga   1140

gtcaggatag tgtccatcac acctcagggg ataagagcac tgattatgct aatttttacc   1200

agggattgtg ggattgtact ggagcttttt ctgatgagtt gtcatttaag cgtggtgatg   1260

tgatttacat tcttagcaag gaatacaata gatatggctg gtgggtagga gaaatgaagg   1320

gagccattgg cttggtgcct aaagcctaca taatggagat gtatgatatt tgagagtcct   1380

ggaaaaggaa aattcttctg cttgtctgca aatgctttgg atttagaagc gtcatgaaag   1440

cacgagtgac agctcctaac ctctccttgt tttattaaac attacttatc tttgactgtt   1500

attttatgca gtcgctcatt aaaatattcc tctgatgtga aattaaatga aggatattaa   1560

tgtaaattag atgcaaccag ttaagttata cctgttgcta ttttgcaaag aaataattat   1620

agtttttatt tacccatttg atttgtgtga agaattcatc actattttat acgtaacata   1680

tagtctacta tagcatagta tgctactatt gctacttctg gtgtgatttg taatgtttct   1740

taatcattgg acatcaatta tttttagaga gtaatgtata atttcatagc attttaaatt   1800

tagtgtatca tgcgagtttt ttttggtaga tgctgaagaa tgtggttgct aaacaaagaa   1860

tgctaaagaa tgttcaaact ttatagataa ctttattgtt attatttatt ttcacacatt   1920

taattcctat taagtacagc cgcaagaaag aaaaaatgat gaagttgcaa atggcagtgt   1980

gctgtcacct gcaacagaag tgcgtaccag aagtatgact catgcaaagc attttaccgt   2040

acaaatatcc tggtgcgatg atgggcctgg caacattttc tactgtactt ttgtttaaat   2100

ttaatgaaac aaaaaattcc taagaaatac caccctacca ctaacaaaat ggtataaaga   2160

atctcccagc caggccaaca tggtgaaacc ctgtctctac taaaaattag ccaagtgtgg   2220

taatgttcac ctgcagtccc agctacttgg gaggccaagg cacgagaatt gcttgaacaa   2280

ggtaggcaga ggttgcagtg agccaagatc gcgccactgc actccagcct gggcgacaga   2340

gtgagactcc atctcagaaa aaaaaaaaaa aaaaaacaga atctcagtgt attctcaaag   2400

taaaaaggca taaccaagca ctctcttatc ttgccttatt gctatactat ttacatccca   2460

ctgcagaaca gcagatttga ggcttttcta tatacttctc agagcactga aaagaaagga   2520

agggtttgca gaggagagtg tagaaatccc agtggtagca tgtaccaaca ggtgagtaga   2580

aaggtagtgt tagcctgaca tttgagttat actctgtgct gcctgagcaa gatttgtaga   2640

atcatataat taccttttca tgtatatttg aaatcagagg tgtttaaaat acctatgaga   2700

taccaatgta gccttaacat atgtcaaaat gcattgctgg ttagataatt atttggacta   2760

cacataaact cctaatattg aatcattacc tatcaggtat tatctttatg gaacttttca   2820

atatctttgc tttataaaga ttctaaacat gtatctgagc tggtaatatt ttaaaatctc   2880

cattatttgt gtaaaactgt ttataagcag tgtttgagag ggtctgcttt accattaccc   2940

cctcaatatc atgatcatcc aatctcaaat gtgaaaaaaa aaaagaaatt tgattttagg   3000

tattgtgagt aaacaagttt atatagagag acattgtgaa gttaaagttt tcagaagtta   3060

catttgtgca gttcttacct tttcctcata tagtgccatt gaaatagact gaaattatct   3120

tggcaaaagt tagacaacca aagacgactt tagtggactg gttttcaaaa cttgagcagc   3180

tgaaaagcaa aagccgttgt ttcccatgac aatgtagcct ttgtggattt gggtttgtgc   3240

tttgggttga aaagaagttt ttagtcctag gccagtagat ggcagcagct tttcattgca   3300

gacaaaacct cttgaaaccc ttcccccatg gcacaaactc gcccatgatg gaaagcatct   3360

agatttctgc ctccttttac agttaatcca ggagagggag tcctttgcca actgatgacc   3420

aacagttcca agccagatag tctcgtgaac agtgacaata cagaaataag gtgttatttc   3480

tgttcagatc tccaccggcc tttgttcttt taaaacttga atataggtgg gagacataag   3540

aaaggaaaga aaagacttaa aactggagtg acaggacaaa taatcattac tttcaattca   3600

tgactgcttt atattcattt gatgaaatca tttgtataca aaccagggag agttttcttt   3660

acacccttga caatatatca catactcttc aagatcataa taatatcatt aatataaatt   3720

taaacaacat ggcttgttag aaaatatgct aattgctatg gtctcattat gtttgcttag   3780

cttttatttg tttttctgtg aacagttaga gagctaattt ttttcaaagg tgattgtaag   3840

tcatatttta tatagcattt tgcttgatta tttgctctgt actgaatttg tactctattg   3900

ccattagatc ttacaataat gttccactct gcaaattttt aaggttcaaa taaagtttaa   3960

ttgtttgcaa aaaaaaaaaa aaaa                                          3984


<210>  407
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  407

Met Pro Asn Pro Ser Ser Thr Ser Ser Pro Tyr Pro Leu Pro Glu Glu 
1               5                   10                  15


Ile Arg Asn Leu Leu Ala Asp Val Glu Thr Phe Val Ala Asp Ile Leu 
            20                  25                  30


Lys Gly Glu Asn Leu Ser Lys Lys Ala Lys Glu Lys Arg Glu Ser Leu 
        35                  40                  45


Ile Lys Lys Ile Lys Asp Val Lys Ser Ile Tyr Leu Gln Glu Phe Gln 
    50                  55                  60


Asp Lys Gly Asp Ala Glu Asp Gly Glu Glu Tyr Asp Asp Pro Phe Ala 
65                  70                  75                  80


Gly Pro Pro Asp Thr Ile Ser Leu Ala Ser Glu Arg Tyr Asp Lys Asp 
                85                  90                  95


Asp Glu Ala Pro Ser Asp Gly Ala Gln Phe Pro Pro Ile Ala Ala Gln 
            100                 105                 110


Asp Leu Pro Phe Val Leu Lys Ala Gly Tyr Leu Glu Lys Arg Arg Lys 
        115                 120                 125


Asp His Ser Phe Leu Gly Phe Glu Trp Gln Lys Arg Trp Cys Ala Leu 
    130                 135                 140


Ser Lys Thr Val Phe Tyr Tyr Tyr Gly Ser Asp Lys Asp Lys Gln Gln 
145                 150                 155                 160


Lys Gly Glu Phe Ala Ile Asp Gly Tyr Ser Val Arg Met Asn Asn Thr 
                165                 170                 175


Leu Arg Lys Asp Gly Lys Lys Asp Cys Cys Phe Glu Ile Ser Ala Pro 
            180                 185                 190


Asp Lys Arg Ile Tyr Gln Phe Thr Ala Ala Ser Pro Lys Asp Ala Glu 
        195                 200                 205


Glu Trp Val Gln Gln Leu Lys Phe Val Leu Gln Asp Met Glu Ser Asp 
    210                 215                 220


Ile Ile Pro Glu Asp Tyr Asp Glu Arg Gly Glu Leu Tyr Asp Asp Val 
225                 230                 235                 240


Asp His Pro Leu Pro Ile Ser Asn Pro Leu Thr Ser Ser Gln Pro Ile 
                245                 250                 255


Asp Asp Glu Ile Tyr Glu Glu Leu Pro Glu Glu Glu Glu Asp Ser Ala 
            260                 265                 270


Pro Val Lys Val Glu Glu Gln Arg Lys Met Ser Gln Asp Ser Val His 
        275                 280                 285


His Thr Ser Gly Asp Lys Ser Thr Asp Tyr Ala Asn Phe Tyr Gln Gly 
    290                 295                 300


Leu Trp Asp Cys Thr Gly Ala Phe Ser Asp Glu Leu Ser Phe Lys Arg 
305                 310                 315                 320


Gly Asp Val Ile Tyr Ile Leu Ser Lys Glu Tyr Asn Arg Tyr Gly Trp 
                325                 330                 335


Trp Val Gly Glu Met Lys Gly Ala Ile Gly Leu Val Pro Lys Ala Tyr 
            340                 345                 350


Ile Met Glu Met Tyr Asp Ile 
        355


<210>  408
<211>  3287
<212>  DNA
<213>  Homo sapiens

<400>  408
cccgctcctc cgcgccgccg ccagccccgc tgcgcgctct gctcttcgca gctccccgga     60

cccgcagcca tggccgacat caagacgggc atcttcgcca agaacgtcca gaagcgactc    120

aaccgcgcgc aggaaaaggt cctccaaaag ctggggaaag ctgatgagac aaaagacgaa    180

cagttcgaag aatatgtcca gaacttcaaa cggcaagaag cagagggtac cagacttcag    240

cgagaactcc gaggatattt agcagcaatc aaaggcatgc aggaggcctc catgaagctc    300

acagagtcgc tgcatgaagt ctatgagcct gactggtatg ggcgggaaga tgtgaaaatg    360

gttggtgaga aatgtgatgt gctgtgggaa gacttccatc aaaaactcgt ggatgggtcc    420

ttgctaacac tggataccta cctggggcaa tttcctgaca taaagaatcg catcgccaag    480

cgcagcagga agctagtgga ctatgacagt gcccgccacc atctggaagc tctgcagagc    540

tccaagagga aggatgagag tcgaatctct aaggcagaag aagaatttca gaaagcacag    600

aaagtgtttg aagagtttaa cgttgactta caagaagagt taccatcatt atggtcaaga    660

cgagttggat tttatgttaa tactttcaaa aacgtctcca gccttgaagc caagtttcat    720

aaggaaattg cggtgctttg ccacaaactg tatgaagtga tgacaaaact gggtgaccag    780

cacgccgaca aggccttcac catccaagga gcgcccagtg attcgggtcc tctccgcatt    840

gcaaagacac catcaccgcc tgaggagcct tcacccctcc cgagcccgac agcaagtcca    900

aatcatacat tagcacctgc gtctcccgca ccagcacggc ctcggtcacc ttcacagaca    960

aggaaagggc ctcctgtccc acctctacct aaagtcaccc cgacaaagga actgcagcag   1020

gagaacatca tcagtttctt tgaggacaac tttgttccag aaatcagtgt gacaacacct   1080

tcccagaatg aagtccctga ggtgaagaaa gaggagactt tgctggatct ggactttgat   1140

cctttcaagc ccgaggtgac acctgcaggt tctgctggag tgacccactc acccatgtct   1200

cagacattgc cctgggacct atggacgaca agcactgatt tggtacagcc ggcttctggt   1260

ggttcattta atggattcac acagccccag gatacttcat tattcacaat gcagacagac   1320

cagagtatga tctgcaactt ggctgaatct gaacaggctc cacccacaga gccaaaagca   1380

gaggagcctc tggctgctgt cacacctgcc gttggtctgg accttggaat ggacactcgg   1440

gctgaggagc cagtggagga ggcagtgatc atacctggag ctgatgctga tgcagctgtt   1500

ggaaccttgg tgtcagcagc tgagggggcc ccaggagagg aagcagaggc ggagaaggcc   1560

actgtccctg ccggggaagg agtaagttta gaggaggcca aaattggaac tgaaaccact   1620

gagggtgcag agagtgccca acctgaagca gaggagctcg aagcaacagt gcctcaggag   1680

aaggtcattc cttcggtggt catagagcct gcctccaacc atgaagagga aggagaaaac   1740

gaaataacta taggtgcaga gcccaaggag accaccgagg acgcggctcc tccgggcccc   1800

accagcgaga caccggagct ggctacggag cagaagccta tccaggaccc tcagcccacg   1860

ccttctgcac cagccatggg ggctgctgac cagctagcat ctgcaaggga ggcctctcag   1920

gaattgcctc ctggctttct ctacaaggtg gaaacactgc atgattttga ggcagcaaat   1980

tctgatgaac ttaccttaca aaggggtgat gtggtgctgg tggtcccctc agattcagaa   2040

gctgatcagg atgcaggctg gctggtggga gtgaaggaat cagactggct tcagtacaga   2100

gaccttgcca cctacaaagg cctctttcca gagaacttca cccgacgctt agattagggc   2160

aacaagtact gcaagaagga gctcagttac ggggttttta aaccttcatg aaaacctgaa   2220

gagttcactt ttgttattat gctcttaatg atttacagac tgatgccaga caaaccttgg   2280

gaagatgtat caatggagca tgtgtgcaaa aaaatgtaag aggaaaaaaa gtaaattaag   2340

gaaaaaatcc tcactcattc ccatgttgtc aataacaggt ttgtttgtgc tttgtccaag   2400

ctgtggagac tcttgtactt gatcccctcc caccaattct aaagtagctt tctccagatc   2460

agactttaat ttctctgcat caggtgtatc gtattgagtg gctgccctgc agaagatgtg   2520

atgaattatc ctgtagtaca agattatctt attcccctgc ccaggtgtga gcacgtgctc   2580

tcgctccctt tcaggtttac tatgtttaaa actaaactgc tgcaaaagtt ctcaatgttc   2640

ttttccaaca catctatata tatatggaca cacagtcacg caagctagtt cccatgactc   2700

ctggatctat gtgtatgcag aaggctacat atacatagtt gcttctttcc tttccattgt   2760

agctctttgc ctctcaattg tcattgatac atgcattgct cttattctgt ctggcattac   2820

aattgcagtt ttgcctaatg gcaaaaccag ccatcccatt ggcaaaagag tcaacagtat   2880

ctgtgtttgt actgtgcagt tttcaggatg agatgacaga tagcacgact acactgaggc   2940

accctcagag aaggcagggc ctgatttatc tagctgtcca gccgctgtgg ctggaggtag   3000

gctagttggg atgggcagct aagcagtctt ctcttctgcc tttatgagat tgggtagaaa   3060

gatggggcat attcatctac ccccaaaaga acactataaa aacagctcct ctatatttcc   3120

acctctttct atttatgcaa ctcatcttca cagattgttc taaagtaaaa tagatggtgt   3180

atgctgtatc cacaaatcat ctgtaacaat tatgttttca gtgctgtgtc attccaaata   3240

aacctttggt aatcttcaac gattacccta aaaaaaaaaa aaaaaaa                 3287


<210>  409
<211>  695
<212>  PRT
<213>  Homo sapiens

<400>  409

Met Ala Asp Ile Lys Thr Gly Ile Phe Ala Lys Asn Val Gln Lys Arg 
1               5                   10                  15


Leu Asn Arg Ala Gln Glu Lys Val Leu Gln Lys Leu Gly Lys Ala Asp 
            20                  25                  30


Glu Thr Lys Asp Glu Gln Phe Glu Glu Tyr Val Gln Asn Phe Lys Arg 
        35                  40                  45


Gln Glu Ala Glu Gly Thr Arg Leu Gln Arg Glu Leu Arg Gly Tyr Leu 
    50                  55                  60


Ala Ala Ile Lys Gly Met Gln Glu Ala Ser Met Lys Leu Thr Glu Ser 
65                  70                  75                  80


Leu His Glu Val Tyr Glu Pro Asp Trp Tyr Gly Arg Glu Asp Val Lys 
                85                  90                  95


Met Val Gly Glu Lys Cys Asp Val Leu Trp Glu Asp Phe His Gln Lys 
            100                 105                 110


Leu Val Asp Gly Ser Leu Leu Thr Leu Asp Thr Tyr Leu Gly Gln Phe 
        115                 120                 125


Pro Asp Ile Lys Asn Arg Ile Ala Lys Arg Ser Arg Lys Leu Val Asp 
    130                 135                 140


Tyr Asp Ser Ala Arg His His Leu Glu Ala Leu Gln Ser Ser Lys Arg 
145                 150                 155                 160


Lys Asp Glu Ser Arg Ile Ser Lys Ala Glu Glu Glu Phe Gln Lys Ala 
                165                 170                 175


Gln Lys Val Phe Glu Glu Phe Asn Val Asp Leu Gln Glu Glu Leu Pro 
            180                 185                 190


Ser Leu Trp Ser Arg Arg Val Gly Phe Tyr Val Asn Thr Phe Lys Asn 
        195                 200                 205


Val Ser Ser Leu Glu Ala Lys Phe His Lys Glu Ile Ala Val Leu Cys 
    210                 215                 220


His Lys Leu Tyr Glu Val Met Thr Lys Leu Gly Asp Gln His Ala Asp 
225                 230                 235                 240


Lys Ala Phe Thr Ile Gln Gly Ala Pro Ser Asp Ser Gly Pro Leu Arg 
                245                 250                 255


Ile Ala Lys Thr Pro Ser Pro Pro Glu Glu Pro Ser Pro Leu Pro Ser 
            260                 265                 270


Pro Thr Ala Ser Pro Asn His Thr Leu Ala Pro Ala Ser Pro Ala Pro 
        275                 280                 285


Ala Arg Pro Arg Ser Pro Ser Gln Thr Arg Lys Gly Pro Pro Val Pro 
    290                 295                 300


Pro Leu Pro Lys Val Thr Pro Thr Lys Glu Leu Gln Gln Glu Asn Ile 
305                 310                 315                 320


Ile Ser Phe Phe Glu Asp Asn Phe Val Pro Glu Ile Ser Val Thr Thr 
                325                 330                 335


Pro Ser Gln Asn Glu Val Pro Glu Val Lys Lys Glu Glu Thr Leu Leu 
            340                 345                 350


Asp Leu Asp Phe Asp Pro Phe Lys Pro Glu Val Thr Pro Ala Gly Ser 
        355                 360                 365


Ala Gly Val Thr His Ser Pro Met Ser Gln Thr Leu Pro Trp Asp Leu 
    370                 375                 380


Trp Thr Thr Ser Thr Asp Leu Val Gln Pro Ala Ser Gly Gly Ser Phe 
385                 390                 395                 400


Asn Gly Phe Thr Gln Pro Gln Asp Thr Ser Leu Phe Thr Met Gln Thr 
                405                 410                 415


Asp Gln Ser Met Ile Cys Asn Leu Ala Glu Ser Glu Gln Ala Pro Pro 
            420                 425                 430


Thr Glu Pro Lys Ala Glu Glu Pro Leu Ala Ala Val Thr Pro Ala Val 
        435                 440                 445


Gly Leu Asp Leu Gly Met Asp Thr Arg Ala Glu Glu Pro Val Glu Glu 
    450                 455                 460


Ala Val Ile Ile Pro Gly Ala Asp Ala Asp Ala Ala Val Gly Thr Leu 
465                 470                 475                 480


Val Ser Ala Ala Glu Gly Ala Pro Gly Glu Glu Ala Glu Ala Glu Lys 
                485                 490                 495


Ala Thr Val Pro Ala Gly Glu Gly Val Ser Leu Glu Glu Ala Lys Ile 
            500                 505                 510


Gly Thr Glu Thr Thr Glu Gly Ala Glu Ser Ala Gln Pro Glu Ala Glu 
        515                 520                 525


Glu Leu Glu Ala Thr Val Pro Gln Glu Lys Val Ile Pro Ser Val Val 
    530                 535                 540


Ile Glu Pro Ala Ser Asn His Glu Glu Glu Gly Glu Asn Glu Ile Thr 
545                 550                 555                 560


Ile Gly Ala Glu Pro Lys Glu Thr Thr Glu Asp Ala Ala Pro Pro Gly 
                565                 570                 575


Pro Thr Ser Glu Thr Pro Glu Leu Ala Thr Glu Gln Lys Pro Ile Gln 
            580                 585                 590


Asp Pro Gln Pro Thr Pro Ser Ala Pro Ala Met Gly Ala Ala Asp Gln 
        595                 600                 605


Leu Ala Ser Ala Arg Glu Ala Ser Gln Glu Leu Pro Pro Gly Phe Leu 
    610                 615                 620


Tyr Lys Val Glu Thr Leu His Asp Phe Glu Ala Ala Asn Ser Asp Glu 
625                 630                 635                 640


Leu Thr Leu Gln Arg Gly Asp Val Val Leu Val Val Pro Ser Asp Ser 
                645                 650                 655


Glu Ala Asp Gln Asp Ala Gly Trp Leu Val Gly Val Lys Glu Ser Asp 
            660                 665                 670


Trp Leu Gln Tyr Arg Asp Leu Ala Thr Tyr Lys Gly Leu Phe Pro Glu 
        675                 680                 685


Asn Phe Thr Arg Arg Leu Asp 
    690                 695


<210>  410
<211>  3161
<212>  DNA
<213>  Homo sapiens

<400>  410
cccgctcctc cgcgccgccg ccagccccgc tgcgcgctct gctcttcgca gctccccgga     60

cccgcagcca tggccgacat caagacgggc atcttcgcca agaacgtcca gaagcgactc    120

aaccgcgcgc aggaaaaggt cctccaaaag ctggggaaag ctgatgagac aaaagacgaa    180

cagttcgaag aatatgtcca gaacttcaaa cggcaagaag cagagggtac cagacttcag    240

cgagaactcc gaggatattt agcagcaatc aaaggcatgc aggaggcctc catgaagctc    300

acagagtcgc tgcatgaagt ctatgagcct gactggtatg ggcgggaaga tgtgaaaatg    360

gttggtgaga aatgtgatgt gctgtgggaa gacttccatc aaaaactcgt ggatgggtcc    420

ttgctaacac tggataccta cctggggcaa tttcctgaca taaagaatcg catcgccaag    480

cgcagcagga agctagtgga ctatgacagt gcccgccacc atctggaagc tctgcagagc    540

tccaagagga aggatgagag tcgaatctct aaggcagaag aagaatttca gaaagcacag    600

aaagtgtttg aagagtttaa cgttgactta caagaagagt taccatcatt atggtcaaga    660

cgagttggat tttatgttaa tactttcaaa aacgtctcca gccttgaagc caagtttcat    720

aaggaaattg cggtgctttg ccacaaactg tatgaagtga tgacaaaact gggtgaccag    780

cacgccgaca aggccttcac catccaagga gcgcccagtg attcgggtcc tctccgcatt    840

gcaaagacac catcaccgcc tgaggagcct tcacccctcc cgagcccgac agcaagtcca    900

aatcatacat tagcacctgc gtctcccgca ccagcacggc ctcggtcacc ttcacagaca    960

aggaaagggc ctcctgtccc acctctacct aaagtcaccc cgacaaagga actgcagcag   1020

gagaacatca tcagtttctt tgaggacaac tttgttccag aaatcagtgt gacaacacct   1080

tcccagaatg aagtccctga ggtgaagaaa gaggagactt tgctggatct ggactttgat   1140

cctttcaagc ccgaggtgac acctgcaggt tctgctggag tgacccactc acccatgtct   1200

cagacattgc cctgggacct atggacgaca agcactgatt tggtacagcc ggcttctggt   1260

ggttcattta atggattcac acagccccag gatacttcat tattcacaat gcagacagac   1320

cagagtatga tctgcaactt gatcatacct ggagctgatg ctgatgcagc tgttggaacc   1380

ttggtgtcag cagctgaggg ggccccagga gaggaagcag aggcggagaa ggccactgtc   1440

cctgccgggg aaggagtaag tttagaggag gccaaaattg gaactgaaac cactgagggt   1500

gcagagagtg cccaacctga agcagaggag ctcgaagcaa cagtgcctca ggagaaggtc   1560

attccttcgg tggtcataga gcctgcctcc aaccatgaag aggaaggaga aaacgaaata   1620

actataggtg cagagcccaa ggagaccacc gaggacgcgg ctcctccggg ccccaccagc   1680

gagacaccgg agctggctac ggagcagaag cctatccagg accctcagcc cacgccttct   1740

gcaccagcca tgggggctgc tgaccagcta gcatctgcaa gggaggcctc tcaggaattg   1800

cctcctggct ttctctacaa ggtggaaaca ctgcatgatt ttgaggcagc aaattctgat   1860

gaacttacct tacaaagggg tgatgtggtg ctggtggtcc cctcagattc agaagctgat   1920

caggatgcag gctggctggt gggagtgaag gaatcagact ggcttcagta cagagacctt   1980

gccacctaca aaggcctctt tccagagaac ttcacccgac gcttagatta gggcaacaag   2040

tactgcaaga aggagctcag ttacggggtt tttaaacctt catgaaaacc tgaagagttc   2100

acttttgtta ttatgctctt aatgatttac agactgatgc cagacaaacc ttgggaagat   2160

gtatcaatgg agcatgtgtg caaaaaaatg taagaggaaa aaaagtaaat taaggaaaaa   2220

atcctcactc attcccatgt tgtcaataac aggtttgttt gtgctttgtc caagctgtgg   2280

agactcttgt acttgatccc ctcccaccaa ttctaaagta gctttctcca gatcagactt   2340

taatttctct gcatcaggtg tatcgtattg agtggctgcc ctgcagaaga tgtgatgaat   2400

tatcctgtag tacaagatta tcttattccc ctgcccaggt gtgagcacgt gctctcgctc   2460

cctttcaggt ttactatgtt taaaactaaa ctgctgcaaa agttctcaat gttcttttcc   2520

aacacatcta tatatatatg gacacacagt cacgcaagct agttcccatg actcctggat   2580

ctatgtgtat gcagaaggct acatatacat agttgcttct ttcctttcca ttgtagctct   2640

ttgcctctca attgtcattg atacatgcat tgctcttatt ctgtctggca ttacaattgc   2700

agttttgcct aatggcaaaa ccagccatcc cattggcaaa agagtcaaca gtatctgtgt   2760

ttgtactgtg cagttttcag gatgagatga cagatagcac gactacactg aggcaccctc   2820

agagaaggca gggcctgatt tatctagctg tccagccgct gtggctggag gtaggctagt   2880

tgggatgggc agctaagcag tcttctcttc tgcctttatg agattgggta gaaagatggg   2940

gcatattcat ctacccccaa aagaacacta taaaaacagc tcctctatat ttccacctct   3000

ttctatttat gcaactcatc ttcacagatt gttctaaagt aaaatagatg gtgtatgctg   3060

tatccacaaa tcatctgtaa caattatgtt ttcagtgctg tgtcattcca aataaacctt   3120

tggtaatctt caacgattac cctaaaaaaa aaaaaaaaaa a                       3161


<210>  411
<211>  653
<212>  PRT
<213>  Homo sapiens

<400>  411

Met Ala Asp Ile Lys Thr Gly Ile Phe Ala Lys Asn Val Gln Lys Arg 
1               5                   10                  15


Leu Asn Arg Ala Gln Glu Lys Val Leu Gln Lys Leu Gly Lys Ala Asp 
            20                  25                  30


Glu Thr Lys Asp Glu Gln Phe Glu Glu Tyr Val Gln Asn Phe Lys Arg 
        35                  40                  45


Gln Glu Ala Glu Gly Thr Arg Leu Gln Arg Glu Leu Arg Gly Tyr Leu 
    50                  55                  60


Ala Ala Ile Lys Gly Met Gln Glu Ala Ser Met Lys Leu Thr Glu Ser 
65                  70                  75                  80


Leu His Glu Val Tyr Glu Pro Asp Trp Tyr Gly Arg Glu Asp Val Lys 
                85                  90                  95


Met Val Gly Glu Lys Cys Asp Val Leu Trp Glu Asp Phe His Gln Lys 
            100                 105                 110


Leu Val Asp Gly Ser Leu Leu Thr Leu Asp Thr Tyr Leu Gly Gln Phe 
        115                 120                 125


Pro Asp Ile Lys Asn Arg Ile Ala Lys Arg Ser Arg Lys Leu Val Asp 
    130                 135                 140


Tyr Asp Ser Ala Arg His His Leu Glu Ala Leu Gln Ser Ser Lys Arg 
145                 150                 155                 160


Lys Asp Glu Ser Arg Ile Ser Lys Ala Glu Glu Glu Phe Gln Lys Ala 
                165                 170                 175


Gln Lys Val Phe Glu Glu Phe Asn Val Asp Leu Gln Glu Glu Leu Pro 
            180                 185                 190


Ser Leu Trp Ser Arg Arg Val Gly Phe Tyr Val Asn Thr Phe Lys Asn 
        195                 200                 205


Val Ser Ser Leu Glu Ala Lys Phe His Lys Glu Ile Ala Val Leu Cys 
    210                 215                 220


His Lys Leu Tyr Glu Val Met Thr Lys Leu Gly Asp Gln His Ala Asp 
225                 230                 235                 240


Lys Ala Phe Thr Ile Gln Gly Ala Pro Ser Asp Ser Gly Pro Leu Arg 
                245                 250                 255


Ile Ala Lys Thr Pro Ser Pro Pro Glu Glu Pro Ser Pro Leu Pro Ser 
            260                 265                 270


Pro Thr Ala Ser Pro Asn His Thr Leu Ala Pro Ala Ser Pro Ala Pro 
        275                 280                 285


Ala Arg Pro Arg Ser Pro Ser Gln Thr Arg Lys Gly Pro Pro Val Pro 
    290                 295                 300


Pro Leu Pro Lys Val Thr Pro Thr Lys Glu Leu Gln Gln Glu Asn Ile 
305                 310                 315                 320


Ile Ser Phe Phe Glu Asp Asn Phe Val Pro Glu Ile Ser Val Thr Thr 
                325                 330                 335


Pro Ser Gln Asn Glu Val Pro Glu Val Lys Lys Glu Glu Thr Leu Leu 
            340                 345                 350


Asp Leu Asp Phe Asp Pro Phe Lys Pro Glu Val Thr Pro Ala Gly Ser 
        355                 360                 365


Ala Gly Val Thr His Ser Pro Met Ser Gln Thr Leu Pro Trp Asp Leu 
    370                 375                 380


Trp Thr Thr Ser Thr Asp Leu Val Gln Pro Ala Ser Gly Gly Ser Phe 
385                 390                 395                 400


Asn Gly Phe Thr Gln Pro Gln Asp Thr Ser Leu Phe Thr Met Gln Thr 
                405                 410                 415


Asp Gln Ser Met Ile Cys Asn Leu Ile Ile Pro Gly Ala Asp Ala Asp 
            420                 425                 430


Ala Ala Val Gly Thr Leu Val Ser Ala Ala Glu Gly Ala Pro Gly Glu 
        435                 440                 445


Glu Ala Glu Ala Glu Lys Ala Thr Val Pro Ala Gly Glu Gly Val Ser 
    450                 455                 460


Leu Glu Glu Ala Lys Ile Gly Thr Glu Thr Thr Glu Gly Ala Glu Ser 
465                 470                 475                 480


Ala Gln Pro Glu Ala Glu Glu Leu Glu Ala Thr Val Pro Gln Glu Lys 
                485                 490                 495


Val Ile Pro Ser Val Val Ile Glu Pro Ala Ser Asn His Glu Glu Glu 
            500                 505                 510


Gly Glu Asn Glu Ile Thr Ile Gly Ala Glu Pro Lys Glu Thr Thr Glu 
        515                 520                 525


Asp Ala Ala Pro Pro Gly Pro Thr Ser Glu Thr Pro Glu Leu Ala Thr 
    530                 535                 540


Glu Gln Lys Pro Ile Gln Asp Pro Gln Pro Thr Pro Ser Ala Pro Ala 
545                 550                 555                 560


Met Gly Ala Ala Asp Gln Leu Ala Ser Ala Arg Glu Ala Ser Gln Glu 
                565                 570                 575


Leu Pro Pro Gly Phe Leu Tyr Lys Val Glu Thr Leu His Asp Phe Glu 
            580                 585                 590


Ala Ala Asn Ser Asp Glu Leu Thr Leu Gln Arg Gly Asp Val Val Leu 
        595                 600                 605


Val Val Pro Ser Asp Ser Glu Ala Asp Gln Asp Ala Gly Trp Leu Val 
    610                 615                 620


Gly Val Lys Glu Ser Asp Trp Leu Gln Tyr Arg Asp Leu Ala Thr Tyr 
625                 630                 635                 640


Lys Gly Leu Phe Pro Glu Asn Phe Thr Arg Arg Leu Asp 
                645                 650


<210>  412
<211>  1520
<212>  DNA
<213>  Homo sapiens

<400>  412
atgctctcag attccacctt acctcaatgt ttgaaaagaa aaaatttcag accaagaagc     60

agcttctcca ctcctggaat ctctgccttg ttcagcctgt ctgcctccac catgtccatc    120

agggtgaccc agaagtccta caaggtgtcc acctctggcc tccgggcctt cagcagctgc    180

tctcacatga gtgggcctgg tgcccacctc agctccttaa gcttctcccg agtgggcagc    240

accagcttcc gggctggcct gggcagaggc tatggtgggg ccagcagcat gggaggcatc    300

actgccgtca tggtcaacca gaacctgctg agccccctga acctggaggt ggaccccaac    360

atccaggcca tgcgcaccca ggagaaggag cagatcaaga ccctcaacaa gaagtttccc    420

tccttcattg acaagatacg tttcctggag cagcagaaca agatgctgga gaccaagggg    480

agcctcctgc agcagcagaa gatggcttgg agcaacgtgg acatgttcga gagctacatc    540

aacaacttta tgcagcggct ggagactctg agccaggaga agccgaagct ggaggcagag    600

cttggcaaca tgcagaggct ggcggagaac ttcaagaaaa agtatgagga tgaaatcaat    660

aagcgtacag agatggagaa tgaatttctc ctcagatgtg ggtgaagctt acatgaacaa    720

ggtagagctg gagtctcgcc tggaagcgct gactgaagag atcagcttcc tcaggcagct    780

gtatgaagaa gagatccagg agctgcagtc ctagatctcg gacacgtctg tggtgctgtc    840

catggacaac agctgctccc tggacatgga cagcatcatc gctgaggtca aggctcagta    900

caaggtgatc gccaaccgca gcctgactga ggctgagagc acggaccaga tgaagtatga    960

ggagctgcag atgctggctg ggaagcgctg ggatgacctg gggcgtacaa aggctgagat   1020

ctccgagatg aaccggaaca tcagctggct ccaggctgag attgagggcc tcaaaggcca   1080

gagggcttcc ctagaggccg ccgtcacaga cgcagagcag cccggggagc tggccatgaa   1140

gggtgccaaa gccaagctgt ctgagctgga gaccgccctg cagctagcca agcaggacat   1200

ggctcagcag ctgcgtgagt acaggaactg gccctggacg cctacaggaa gctgctggag   1260

ggcgaggaga gctggctgga gtctgggatg cagaacatga gtatccatac gaagaccacc   1320

tgtggctatg caggtggtct gagctctcct acgggcgcct cacaagcccc ggcctcagct   1380

acggcctggg ctccagcttt ggctctggcg cgggctccag ctccttcagc cacaccagct   1440

ccaccagggc cgtggctgtg aagatcaaga cccgcgatgg gaagctggcg tccgagtcct   1500

ctgacattct gcccaagtga                                               1520


<210>  413
<211>  4894
<212>  DNA
<213>  Homo sapiens

<400>  413
ctgtcaggtg actctcccgt ggcgccatgg cggaagcaga ggagcaggaa actgggtccc     60

ttgaagaatc tacagatgag tctgaggaag aagagagcga agaggaaccc aagctgaagt    120

atgaaaggct ttccaatggg gtaactgaaa tacttcagaa ggatgcagct agctgcatga    180

cagtccatga caagtttttg gcattgggca cacattatgg caaggtttat ttacttgatg    240

tccaggggaa catcactcag aagtttgatg taagtcctgt gaagataaat cagattagct    300

tggatgaaag tggagagcac atgggtgtgt gttcagagga tggcaaggtg caggtatttg    360

gactgtattc tggagaagaa tttcacgaga cttttgactg tcccattaaa attattgctg    420

tgcacccaca tttcgtgaga tccagttgca agcagtttgt gaccggaggg aagaagctgc    480

tactgtttga acggtcttgg atgaacagat ggaagtctgc tgttctgcat gaaggggaag    540

ggaacataag gagtgtgaag tggagaggcc atctgattgc ttgggccaat aatatgggtg    600

tgaagatttt tgacatcatc tcaaagcaaa gaatcaccaa tgtgccccgg gatgatataa    660

gtcttcgccc agacatgtat ccctgcagcc tctgctggaa ggacaatgtg acactgatta    720

ttggctgggg gacttctgtc aaggtgtgct cagtgaagga acggcatgcc agtgaaatga    780

gggatttgcc aagtcgatat gttgaaatag tgtctcagtt tgaaactgaa ttctacatca    840

gtggacttgc acctctctgt gatcagcttg ttgtactttc gtatgtaaag gagatttcag    900

aaaaaacgga aagagaatac tgtgccaggc ctagactgga catcatccag ccactttctg    960

agacttgtga agagatctct tctgatgctt tgacagtcag aggctttcag gagaatgaat   1020

gtagagatta tcatttagaa tactctgaag gggaatcact tttttacatc gtgagtccga   1080

gagatgttgt agtggccaag gaacgagacc aagatgatca cattgactgg ctccttgaaa   1140

agaagaaata tgaagaagca ttgatggcag ctgaaattag ccaaaaaaat attaaaagac   1200

ataagattct ggatattggc ttggcatata taaatcacct ggtggagaga ggagactatg   1260

acatagcagc acgcaaatgc cagaaaattc ttgggaaaaa tgcagcactc tgggaatatg   1320

aagtttataa atttaaagaa attggacagc ttaaggctat tagtccttat ttgccaagag   1380

gtgatccagt tctgaaacca ctcatctatg aaatgatctt acatgaattt ttggagagtg   1440

attatgaggg ttttgccaca ttgatccgag aatggcctgg agatctgtat aataattcag   1500

tcatagttca agcagttcgg gatcatttga agaaagatag tcagaacaag actttactta   1560

aaaccctggc agaattgtac acctatgaca agaactatgg caatgctctg gaaatatact   1620

taacattaag acataaagac gtttttcagt tgatccacaa gcataatctt ttcagttcta   1680

tcaaggataa aattgtttta ttaatggatt ttgattcaga gaaagctgtt gacatgcttt   1740

tggacaatga agataaaatt tcaattaaaa aggtagtgga agaattggaa gacagaccag   1800

agctacagca tgtgtatttg cataagcttt tcaagagaga ccaccataag gggcagcgtt   1860

accatgaaaa acagatcagt ctttatgctg aatatgatcg accaaactta cttccctttc   1920

tccgagacag tacccattgc ccacttgaaa aggctcttga gatctgtcaa cagagaaact   1980

ttgtagaaga gacagtttat cttctgagcc gaatgggtaa tagccgaagt gccctgaaga   2040

tgattatgga ggaattacat gatgttgata aagcaatcga atttgccaag gagcaagatg   2100

atggagagct gtgggaagat ttgattttat attccattga caaaccacca tttattactg   2160

gcttgttaaa caacattggc acacatgttg acccaattct actgattcac cgtattaagg   2220

aaggaatgga gatccccaat ttgagagatt ccttggttaa aattctgcaa gactacaatt   2280

tgcaaattct gcttcgtgaa ggctgcaaga agattctcgt agctgactct ttgtccttac   2340

tgaagaaaat gcaccgaact caaatgaaag gtgttcttgt tgatgaggag aacatctgtg   2400

agtcgtgcct ttcccctatt cttccatcag atgcagctaa gcccttcagc gtggtggtct   2460

tccattgccg gcacatgttc cacaaggagt gcctgcccat gcccagcatg aactctgctg   2520

cacagttctg caacatctgc agtgctaaga accgtggacc aggaagtgca attttggaga   2580

tgaaaaaata gctcatttct ccttgtcagt ctccttgtca ccactctttt tgagactgtt   2640

tttgcaacaa caaaagcatt tgttgacact cgtgctgtta agagatttgt ttatgtttat   2700

attatactca aaaacaattt cttcatctat tcctgtacta atggtttctc tttgcagttc   2760

acagagaatt tggggctctc ttcatgcctt gaaattttgg ggtccatagt gaatattttg   2820

ttatttattt gtttggctca ttctttatat agtaatggaa acataagtct aggagttaga   2880

aatgaatttt ttagacctta gtaaaaccat ttaaccataa aatggacaac tgagaattct   2940

cccagctgcc tgaaagcgtc gccaactgtg gttatcctgc aagctgctac ctgcaacttg   3000

gacgttgttt ccacgtgctc tgctggctac gattcttgca ttctgggttt ggcttttttc   3060

tgtgtcatca actatggtta tcctctaaat aggcatttaa tgaaacattg tacaaattgt   3120

cactcatttg atgacacctg ggaataacat tagcaggctg atgtcctgca ccattatgtt   3180

tactaatcac atgttctgtg tgctgtgacg actgtcaaag agtatctggc catggcggac   3240

actcagcatt tgttgattga ataaatgtta gctcttctca ttgtgaagga ctcactttta   3300

ctgggataaa caaatgcagt taagaattct ggcacccttg taaggaagaa aagagagttc   3360

aacaccttcg agtctgagcg cttgtggcta gagtttgcca ggagggagga aaccagtgac   3420

cctgaaaact gagggtgcct caggagcagt gggaccacct gatgctgaag gacggactaa   3480

tgatgtttcc tcttgccttc tctggtgcct ccattgccct catggaacag agcatatcat   3540

agagggagaa aagtcaaact tgtaattgtg tcttacagtt actggcttca tcttccttgg   3600

gatatatggt catcctctaa tgagtgtaaa agtgcgcaaa acacatcctt attgttcctg   3660

atctcttagt cccataaatg ggaacaaata cagctttctg cttctttctt tttggggaaa   3720

ggacagggtg ctagtgagta ctgacagcat gccagctacc gaagtcaccc agccattccc   3780

atgagcagca gttcatttaa ttgtcacagc gtcgccagga agaagatctg ataaacctag   3840

gtttacagat aaagaaagca aaatgtagag atgttgttga ggtcacagag gtgactgcct   3900

aacttcagag cagggcttct gatcccttta agaaattaca gggccagccg ggcatggtgg   3960

ctcacgcccg taatcccagg gctttgggag gccttggcag gtggatcacc tgagatcgca   4020

cgttcgagac cagcctgacc aacatggaga aaccccatct ctactaaaaa cacaaattag   4080

ccaggcgtgg tggtacatgc ctgtaatccc agctactcag gaggctgagg caggagaatc   4140

acttgacccc aggagacgta ggttgtggtg agctgagatc gcgccattgc actccagcct   4200

gggcaacaag agcaaaactc cgtctcaaaa aagaaaagaa aagaaaagaa atcatagggc   4260

caagttcaaa ggaaatgcac agaacatatc ttcacattag agttaagaat tctctagcaa   4320

acaacagatt tttttgttgt tgttagtcac aaatacttag aactggaagg ctctttgtta   4380

ttattgaatg tacccctcag ccttctcagc atttccttat cccaagacta gtgtgctttc   4440

tgctacactg ctagttttca gttttgttct tacccaattg ttttttcttt tcaacattac   4500

caatttacag attcagttta ttacatttac attaatcctc acttatgatt tgagcaagct   4560

catttccaga aaagtttact ttaagatcat caataggatt tgctaatttc agtgaagtca   4620

ttttgcttca ggggtaaatt atcctagtta ccaagtccta tttggacata aagaaaatcc   4680

tacttataga aaaggagaaa ataattaaac agtcttcatt tttaagtaac tgatttaaaa   4740

ggaaaataat aaaatatgtt cgtttatcat ttcagaaatt gctgtaacac actggaaaat   4800

tcctgaacaa tatagatttt atcgttaata aaaaacacta gctttcgttc cttagaatgt   4860

cttttctttt gaataaacag tattgggtga ttta                               4894


<210>  414
<211>  854
<212>  PRT
<213>  Homo sapiens

<400>  414

Met Ala Glu Ala Glu Glu Gln Glu Thr Gly Ser Leu Glu Glu Ser Thr 
1               5                   10                  15


Asp Glu Ser Glu Glu Glu Glu Ser Glu Glu Glu Pro Lys Leu Lys Tyr 
            20                  25                  30


Glu Arg Leu Ser Asn Gly Val Thr Glu Ile Leu Gln Lys Asp Ala Ala 
        35                  40                  45


Ser Cys Met Thr Val His Asp Lys Phe Leu Ala Leu Gly Thr His Tyr 
    50                  55                  60


Gly Lys Val Tyr Leu Leu Asp Val Gln Gly Asn Ile Thr Gln Lys Phe 
65                  70                  75                  80


Asp Val Ser Pro Val Lys Ile Asn Gln Ile Ser Leu Asp Glu Ser Gly 
                85                  90                  95


Glu His Met Gly Val Cys Ser Glu Asp Gly Lys Val Gln Val Phe Gly 
            100                 105                 110


Leu Tyr Ser Gly Glu Glu Phe His Glu Thr Phe Asp Cys Pro Ile Lys 
        115                 120                 125


Ile Ile Ala Val His Pro His Phe Val Arg Ser Ser Cys Lys Gln Phe 
    130                 135                 140


Val Thr Gly Gly Lys Lys Leu Leu Leu Phe Glu Arg Ser Trp Met Asn 
145                 150                 155                 160


Arg Trp Lys Ser Ala Val Leu His Glu Gly Glu Gly Asn Ile Arg Ser 
                165                 170                 175


Val Lys Trp Arg Gly His Leu Ile Ala Trp Ala Asn Asn Met Gly Val 
            180                 185                 190


Lys Ile Phe Asp Ile Ile Ser Lys Gln Arg Ile Thr Asn Val Pro Arg 
        195                 200                 205


Asp Asp Ile Ser Leu Arg Pro Asp Met Tyr Pro Cys Ser Leu Cys Trp 
    210                 215                 220


Lys Asp Asn Val Thr Leu Ile Ile Gly Trp Gly Thr Ser Val Lys Val 
225                 230                 235                 240


Cys Ser Val Lys Glu Arg His Ala Ser Glu Met Arg Asp Leu Pro Ser 
                245                 250                 255


Arg Tyr Val Glu Ile Val Ser Gln Phe Glu Thr Glu Phe Tyr Ile Ser 
            260                 265                 270


Gly Leu Ala Pro Leu Cys Asp Gln Leu Val Val Leu Ser Tyr Val Lys 
        275                 280                 285


Glu Ile Ser Glu Lys Thr Glu Arg Glu Tyr Cys Ala Arg Pro Arg Leu 
    290                 295                 300


Asp Ile Ile Gln Pro Leu Ser Glu Thr Cys Glu Glu Ile Ser Ser Asp 
305                 310                 315                 320


Ala Leu Thr Val Arg Gly Phe Gln Glu Asn Glu Cys Arg Asp Tyr His 
                325                 330                 335


Leu Glu Tyr Ser Glu Gly Glu Ser Leu Phe Tyr Ile Val Ser Pro Arg 
            340                 345                 350


Asp Val Val Val Ala Lys Glu Arg Asp Gln Asp Asp His Ile Asp Trp 
        355                 360                 365


Leu Leu Glu Lys Lys Lys Tyr Glu Glu Ala Leu Met Ala Ala Glu Ile 
    370                 375                 380


Ser Gln Lys Asn Ile Lys Arg His Lys Ile Leu Asp Ile Gly Leu Ala 
385                 390                 395                 400


Tyr Ile Asn His Leu Val Glu Arg Gly Asp Tyr Asp Ile Ala Ala Arg 
                405                 410                 415


Lys Cys Gln Lys Ile Leu Gly Lys Asn Ala Ala Leu Trp Glu Tyr Glu 
            420                 425                 430


Val Tyr Lys Phe Lys Glu Ile Gly Gln Leu Lys Ala Ile Ser Pro Tyr 
        435                 440                 445


Leu Pro Arg Gly Asp Pro Val Leu Lys Pro Leu Ile Tyr Glu Met Ile 
    450                 455                 460


Leu His Glu Phe Leu Glu Ser Asp Tyr Glu Gly Phe Ala Thr Leu Ile 
465                 470                 475                 480


Arg Glu Trp Pro Gly Asp Leu Tyr Asn Asn Ser Val Ile Val Gln Ala 
                485                 490                 495


Val Arg Asp His Leu Lys Lys Asp Ser Gln Asn Lys Thr Leu Leu Lys 
            500                 505                 510


Thr Leu Ala Glu Leu Tyr Thr Tyr Asp Lys Asn Tyr Gly Asn Ala Leu 
        515                 520                 525


Glu Ile Tyr Leu Thr Leu Arg His Lys Asp Val Phe Gln Leu Ile His 
    530                 535                 540


Lys His Asn Leu Phe Ser Ser Ile Lys Asp Lys Ile Val Leu Leu Met 
545                 550                 555                 560


Asp Phe Asp Ser Glu Lys Ala Val Asp Met Leu Leu Asp Asn Glu Asp 
                565                 570                 575


Lys Ile Ser Ile Lys Lys Val Val Glu Glu Leu Glu Asp Arg Pro Glu 
            580                 585                 590


Leu Gln His Val Tyr Leu His Lys Leu Phe Lys Arg Asp His His Lys 
        595                 600                 605


Gly Gln Arg Tyr His Glu Lys Gln Ile Ser Leu Tyr Ala Glu Tyr Asp 
    610                 615                 620


Arg Pro Asn Leu Leu Pro Phe Leu Arg Asp Ser Thr His Cys Pro Leu 
625                 630                 635                 640


Glu Lys Ala Leu Glu Ile Cys Gln Gln Arg Asn Phe Val Glu Glu Thr 
                645                 650                 655


Val Tyr Leu Leu Ser Arg Met Gly Asn Ser Arg Ser Ala Leu Lys Met 
            660                 665                 670


Ile Met Glu Glu Leu His Asp Val Asp Lys Ala Ile Glu Phe Ala Lys 
        675                 680                 685


Glu Gln Asp Asp Gly Glu Leu Trp Glu Asp Leu Ile Leu Tyr Ser Ile 
    690                 695                 700


Asp Lys Pro Pro Phe Ile Thr Gly Leu Leu Asn Asn Ile Gly Thr His 
705                 710                 715                 720


Val Asp Pro Ile Leu Leu Ile His Arg Ile Lys Glu Gly Met Glu Ile 
                725                 730                 735


Pro Asn Leu Arg Asp Ser Leu Val Lys Ile Leu Gln Asp Tyr Asn Leu 
            740                 745                 750


Gln Ile Leu Leu Arg Glu Gly Cys Lys Lys Ile Leu Val Ala Asp Ser 
        755                 760                 765


Leu Ser Leu Leu Lys Lys Met His Arg Thr Gln Met Lys Gly Val Leu 
    770                 775                 780


Val Asp Glu Glu Asn Ile Cys Glu Ser Cys Leu Ser Pro Ile Leu Pro 
785                 790                 795                 800


Ser Asp Ala Ala Lys Pro Phe Ser Val Val Val Phe His Cys Arg His 
                805                 810                 815


Met Phe His Lys Glu Cys Leu Pro Met Pro Ser Met Asn Ser Ala Ala 
            820                 825                 830


Gln Phe Cys Asn Ile Cys Ser Ala Lys Asn Arg Gly Pro Gly Ser Ala 
        835                 840                 845


Ile Leu Glu Met Lys Lys 
    850


<210>  415
<211>  4819
<212>  DNA
<213>  Homo sapiens

<400>  415
ctgtcaggtg actctcccgt ggcgccatgg cggaagcaga ggagcaggaa actgggtccc     60

ttgaagaatc tacagatgag tctgaggaag aagagagcga agaggaaccc aagctgaagt    120

atgaaaggct ttccaatggg gtaactgaaa tacttcagaa ggatgcagct agctgcatga    180

cagtccatga caagtttttg gcattgggca cacattatgg caaggtttat ttacttgatg    240

tccaggggaa catcactcag aagtttgatg tagtgcaggt atttggactg tattctggag    300

aagaatttca cgagactttt gactgtccca ttaaaattat tgctgtgcac ccacatttcg    360

tgagatccag ttgcaagcag tttgtgaccg gagggaagaa gctgctactg tttgaacggt    420

cttggatgaa cagatggaag tctgctgttc tgcatgaagg ggaagggaac ataaggagtg    480

tgaagtggag aggccatctg attgcttggg ccaataatat gggtgtgaag atttttgaca    540

tcatctcaaa gcaaagaatc accaatgtgc cccgggatga tataagtctt cgcccagaca    600

tgtatccctg cagcctctgc tggaaggaca atgtgacact gattattggc tgggggactt    660

ctgtcaaggt gtgctcagtg aaggaacggc atgccagtga aatgagggat ttgccaagtc    720

gatatgttga aatagtgtct cagtttgaaa ctgaattcta catcagtgga cttgcacctc    780

tctgtgatca gcttgttgta ctttcgtatg taaaggagat ttcagaaaaa acggaaagag    840

aatactgtgc caggcctaga ctggacatca tccagccact ttctgagact tgtgaagaga    900

tctcttctga tgctttgaca gtcagaggct ttcaggagaa tgaatgtaga gattatcatt    960

tagaatactc tgaaggggaa tcactttttt acatcgtgag tccgagagat gttgtagtgg   1020

ccaaggaacg agaccaagat gatcacattg actggctcct tgaaaagaag aaatatgaag   1080

aagcattgat ggcagctgaa attagccaaa aaaatattaa aagacataag attctggata   1140

ttggcttggc atatataaat cacctggtgg agagaggaga ctatgacata gcagcacgca   1200

aatgccagaa aattcttggg aaaaatgcag cactctggga atatgaagtt tataaattta   1260

aagaaattgg acagcttaag gctattagtc cttatttgcc aagaggtgat ccagttctga   1320

aaccactcat ctatgaaatg atcttacatg aatttttgga gagtgattat gagggttttg   1380

ccacattgat ccgagaatgg cctggagatc tgtataataa ttcagtcata gttcaagcag   1440

ttcgggatca tttgaagaaa gatagtcaga acaagacttt acttaaaacc ctggcagaat   1500

tgtacaccta tgacaagaac tatggcaatg ctctggaaat atacttaaca ttaagacata   1560

aagacgtttt tcagttgatc cacaagcata atcttttcag ttctatcaag gataaaattg   1620

ttttattaat ggattttgat tcagagaaag ctgttgacat gcttttggac aatgaagata   1680

aaatttcaat taaaaaggta gtggaagaat tggaagacag accagagcta cagcatgtgt   1740

atttgcataa gcttttcaag agagaccacc ataaggggca gcgttaccat gaaaaacaga   1800

tcagtcttta tgctgaatat gatcgaccaa acttacttcc ctttctccga gacagtaccc   1860

attgcccact tgaaaaggct cttgagatct gtcaacagag aaactttgta gaagagacag   1920

tttatcttct gagccgaatg ggtaatagcc gaagtgccct gaagatgatt atggaggaat   1980

tacatgatgt tgataaagca atcgaatttg ccaaggagca agatgatgga gagctgtggg   2040

aagatttgat tttatattcc attgacaaac caccatttat tactggcttg ttaaacaaca   2100

ttggcacaca tgttgaccca attctactga ttcaccgtat taaggaagga atggagatcc   2160

ccaatttgag agattccttg gttaaaattc tgcaagacta caatttgcaa attctgcttc   2220

gtgaaggctg caagaagatt ctcgtagctg actctttgtc cttactgaag aaaatgcacc   2280

gaactcaaat gaaaggtgtt cttgttgatg aggagaacat ctgtgagtcg tgcctttccc   2340

ctattcttcc atcagatgca gctaagccct tcagcgtggt ggtcttccat tgccggcaca   2400

tgttccacaa ggagtgcctg cccatgccca gcatgaactc tgctgcacag ttctgcaaca   2460

tctgcagtgc taagaaccgt ggaccaggaa gtgcaatttt ggagatgaaa aaatagctca   2520

tttctccttg tcagtctcct tgtcaccact ctttttgaga ctgtttttgc aacaacaaaa   2580

gcatttgttg acactcgtgc tgttaagaga tttgtttatg tttatattat actcaaaaac   2640

aatttcttca tctattcctg tactaatggt ttctctttgc agttcacaga gaatttgggg   2700

ctctcttcat gccttgaaat tttggggtcc atagtgaata ttttgttatt tatttgtttg   2760

gctcattctt tatatagtaa tggaaacata agtctaggag ttagaaatga attttttaga   2820

ccttagtaaa accatttaac cataaaatgg acaactgaga attctcccag ctgcctgaaa   2880

gcgtcgccaa ctgtggttat cctgcaagct gctacctgca acttggacgt tgtttccacg   2940

tgctctgctg gctacgattc ttgcattctg ggtttggctt ttttctgtgt catcaactat   3000

ggttatcctc taaataggca tttaatgaaa cattgtacaa attgtcactc atttgatgac   3060

acctgggaat aacattagca ggctgatgtc ctgcaccatt atgtttacta atcacatgtt   3120

ctgtgtgctg tgacgactgt caaagagtat ctggccatgg cggacactca gcatttgttg   3180

attgaataaa tgttagctct tctcattgtg aaggactcac ttttactggg ataaacaaat   3240

gcagttaaga attctggcac ccttgtaagg aagaaaagag agttcaacac cttcgagtct   3300

gagcgcttgt ggctagagtt tgccaggagg gaggaaacca gtgaccctga aaactgaggg   3360

tgcctcagga gcagtgggac cacctgatgc tgaaggacgg actaatgatg tttcctcttg   3420

ccttctctgg tgcctccatt gccctcatgg aacagagcat atcatagagg gagaaaagtc   3480

aaacttgtaa ttgtgtctta cagttactgg cttcatcttc cttgggatat atggtcatcc   3540

tctaatgagt gtaaaagtgc gcaaaacaca tccttattgt tcctgatctc ttagtcccat   3600

aaatgggaac aaatacagct ttctgcttct ttctttttgg ggaaaggaca gggtgctagt   3660

gagtactgac agcatgccag ctaccgaagt cacccagcca ttcccatgag cagcagttca   3720

tttaattgtc acagcgtcgc caggaagaag atctgataaa cctaggttta cagataaaga   3780

aagcaaaatg tagagatgtt gttgaggtca cagaggtgac tgcctaactt cagagcaggg   3840

cttctgatcc ctttaagaaa ttacagggcc agccgggcat ggtggctcac gcccgtaatc   3900

ccagggcttt gggaggcctt ggcaggtgga tcacctgaga tcgcacgttc gagaccagcc   3960

tgaccaacat ggagaaaccc catctctact aaaaacacaa attagccagg cgtggtggta   4020

catgcctgta atcccagcta ctcaggaggc tgaggcagga gaatcacttg accccaggag   4080

acgtaggttg tggtgagctg agatcgcgcc attgcactcc agcctgggca acaagagcaa   4140

aactccgtct caaaaaagaa aagaaaagaa aagaaatcat agggccaagt tcaaaggaaa   4200

tgcacagaac atatcttcac attagagtta agaattctct agcaaacaac agattttttt   4260

gttgttgtta gtcacaaata cttagaactg gaaggctctt tgttattatt gaatgtaccc   4320

ctcagccttc tcagcatttc cttatcccaa gactagtgtg ctttctgcta cactgctagt   4380

tttcagtttt gttcttaccc aattgttttt tcttttcaac attaccaatt tacagattca   4440

gtttattaca tttacattaa tcctcactta tgatttgagc aagctcattt ccagaaaagt   4500

ttactttaag atcatcaata ggatttgcta atttcagtga agtcattttg cttcaggggt   4560

aaattatcct agttaccaag tcctatttgg acataaagaa aatcctactt atagaaaagg   4620

agaaaataat taaacagtct tcatttttaa gtaactgatt taaaaggaaa ataataaaat   4680

atgttcgttt atcatttcag aaattgctgt aacacactgg aaaattcctg aacaatatag   4740

attttatcgt taataaaaaa cactagcttt cgttccttag aatgtctttt cttttgaata   4800

aacagtattg ggtgattta                                                4819


<210>  416
<211>  829
<212>  PRT
<213>  Homo sapiens

<400>  416

Met Ala Glu Ala Glu Glu Gln Glu Thr Gly Ser Leu Glu Glu Ser Thr 
1               5                   10                  15


Asp Glu Ser Glu Glu Glu Glu Ser Glu Glu Glu Pro Lys Leu Lys Tyr 
            20                  25                  30


Glu Arg Leu Ser Asn Gly Val Thr Glu Ile Leu Gln Lys Asp Ala Ala 
        35                  40                  45


Ser Cys Met Thr Val His Asp Lys Phe Leu Ala Leu Gly Thr His Tyr 
    50                  55                  60


Gly Lys Val Tyr Leu Leu Asp Val Gln Gly Asn Ile Thr Gln Lys Phe 
65                  70                  75                  80


Asp Val Val Gln Val Phe Gly Leu Tyr Ser Gly Glu Glu Phe His Glu 
                85                  90                  95


Thr Phe Asp Cys Pro Ile Lys Ile Ile Ala Val His Pro His Phe Val 
            100                 105                 110


Arg Ser Ser Cys Lys Gln Phe Val Thr Gly Gly Lys Lys Leu Leu Leu 
        115                 120                 125


Phe Glu Arg Ser Trp Met Asn Arg Trp Lys Ser Ala Val Leu His Glu 
    130                 135                 140


Gly Glu Gly Asn Ile Arg Ser Val Lys Trp Arg Gly His Leu Ile Ala 
145                 150                 155                 160


Trp Ala Asn Asn Met Gly Val Lys Ile Phe Asp Ile Ile Ser Lys Gln 
                165                 170                 175


Arg Ile Thr Asn Val Pro Arg Asp Asp Ile Ser Leu Arg Pro Asp Met 
            180                 185                 190


Tyr Pro Cys Ser Leu Cys Trp Lys Asp Asn Val Thr Leu Ile Ile Gly 
        195                 200                 205


Trp Gly Thr Ser Val Lys Val Cys Ser Val Lys Glu Arg His Ala Ser 
    210                 215                 220


Glu Met Arg Asp Leu Pro Ser Arg Tyr Val Glu Ile Val Ser Gln Phe 
225                 230                 235                 240


Glu Thr Glu Phe Tyr Ile Ser Gly Leu Ala Pro Leu Cys Asp Gln Leu 
                245                 250                 255


Val Val Leu Ser Tyr Val Lys Glu Ile Ser Glu Lys Thr Glu Arg Glu 
            260                 265                 270


Tyr Cys Ala Arg Pro Arg Leu Asp Ile Ile Gln Pro Leu Ser Glu Thr 
        275                 280                 285


Cys Glu Glu Ile Ser Ser Asp Ala Leu Thr Val Arg Gly Phe Gln Glu 
    290                 295                 300


Asn Glu Cys Arg Asp Tyr His Leu Glu Tyr Ser Glu Gly Glu Ser Leu 
305                 310                 315                 320


Phe Tyr Ile Val Ser Pro Arg Asp Val Val Val Ala Lys Glu Arg Asp 
                325                 330                 335


Gln Asp Asp His Ile Asp Trp Leu Leu Glu Lys Lys Lys Tyr Glu Glu 
            340                 345                 350


Ala Leu Met Ala Ala Glu Ile Ser Gln Lys Asn Ile Lys Arg His Lys 
        355                 360                 365


Ile Leu Asp Ile Gly Leu Ala Tyr Ile Asn His Leu Val Glu Arg Gly 
    370                 375                 380


Asp Tyr Asp Ile Ala Ala Arg Lys Cys Gln Lys Ile Leu Gly Lys Asn 
385                 390                 395                 400


Ala Ala Leu Trp Glu Tyr Glu Val Tyr Lys Phe Lys Glu Ile Gly Gln 
                405                 410                 415


Leu Lys Ala Ile Ser Pro Tyr Leu Pro Arg Gly Asp Pro Val Leu Lys 
            420                 425                 430


Pro Leu Ile Tyr Glu Met Ile Leu His Glu Phe Leu Glu Ser Asp Tyr 
        435                 440                 445


Glu Gly Phe Ala Thr Leu Ile Arg Glu Trp Pro Gly Asp Leu Tyr Asn 
    450                 455                 460


Asn Ser Val Ile Val Gln Ala Val Arg Asp His Leu Lys Lys Asp Ser 
465                 470                 475                 480


Gln Asn Lys Thr Leu Leu Lys Thr Leu Ala Glu Leu Tyr Thr Tyr Asp 
                485                 490                 495


Lys Asn Tyr Gly Asn Ala Leu Glu Ile Tyr Leu Thr Leu Arg His Lys 
            500                 505                 510


Asp Val Phe Gln Leu Ile His Lys His Asn Leu Phe Ser Ser Ile Lys 
        515                 520                 525


Asp Lys Ile Val Leu Leu Met Asp Phe Asp Ser Glu Lys Ala Val Asp 
    530                 535                 540


Met Leu Leu Asp Asn Glu Asp Lys Ile Ser Ile Lys Lys Val Val Glu 
545                 550                 555                 560


Glu Leu Glu Asp Arg Pro Glu Leu Gln His Val Tyr Leu His Lys Leu 
                565                 570                 575


Phe Lys Arg Asp His His Lys Gly Gln Arg Tyr His Glu Lys Gln Ile 
            580                 585                 590


Ser Leu Tyr Ala Glu Tyr Asp Arg Pro Asn Leu Leu Pro Phe Leu Arg 
        595                 600                 605


Asp Ser Thr His Cys Pro Leu Glu Lys Ala Leu Glu Ile Cys Gln Gln 
    610                 615                 620


Arg Asn Phe Val Glu Glu Thr Val Tyr Leu Leu Ser Arg Met Gly Asn 
625                 630                 635                 640


Ser Arg Ser Ala Leu Lys Met Ile Met Glu Glu Leu His Asp Val Asp 
                645                 650                 655


Lys Ala Ile Glu Phe Ala Lys Glu Gln Asp Asp Gly Glu Leu Trp Glu 
            660                 665                 670


Asp Leu Ile Leu Tyr Ser Ile Asp Lys Pro Pro Phe Ile Thr Gly Leu 
        675                 680                 685


Leu Asn Asn Ile Gly Thr His Val Asp Pro Ile Leu Leu Ile His Arg 
    690                 695                 700


Ile Lys Glu Gly Met Glu Ile Pro Asn Leu Arg Asp Ser Leu Val Lys 
705                 710                 715                 720


Ile Leu Gln Asp Tyr Asn Leu Gln Ile Leu Leu Arg Glu Gly Cys Lys 
                725                 730                 735


Lys Ile Leu Val Ala Asp Ser Leu Ser Leu Leu Lys Lys Met His Arg 
            740                 745                 750


Thr Gln Met Lys Gly Val Leu Val Asp Glu Glu Asn Ile Cys Glu Ser 
        755                 760                 765


Cys Leu Ser Pro Ile Leu Pro Ser Asp Ala Ala Lys Pro Phe Ser Val 
    770                 775                 780


Val Val Phe His Cys Arg His Met Phe His Lys Glu Cys Leu Pro Met 
785                 790                 795                 800


Pro Ser Met Asn Ser Ala Ala Gln Phe Cys Asn Ile Cys Ser Ala Lys 
                805                 810                 815


Asn Arg Gly Pro Gly Ser Ala Ile Leu Glu Met Lys Lys 
            820                 825


<210>  417
<211>  8209
<212>  DNA
<213>  Homo sapiens

<400>  417
gtctatggga agttcgggga cttgacagcc gctgccgccg cagggcattt ttggtcgaag     60

agagctgaag taatgagaag acatcatgga ggcccagtcc cacagctcca cgaccactga    120

aaagaaaaaa gttgagaatt ccatagtgaa gtgctccact cgaacagatg tgagcgagaa    180

agccgttgcc tccagcacca cttctaatga ggatgaaagt cctggacaga cttatcacag    240

agagagaaga aacgcaatca ctatgcagcc acagaatgtc caggggctca gcaaagtcag    300

tgaggaacct tcaacatcga gtgacgagag ggcctcattg atcaagaaag agatccatgg    360

gtccctgcca cacgtggcgg agccctctgt gccgtaccgc gggacggtgt ttgccatgga    420

ccccaggaat ggttacatgg agccccacta ccaccctcct catcttttcc ctgccttcca    480

tcctcctgta ccaattgatg ccagacatca tgagggccgt taccattacg atccatctcc    540

gattcctcca ttgcatatga cttccgcctt atctagtagc cctacgtatc cggacctgcc    600

cttcattagg atctccccac accggaaccc cactgctgct tccgagtctc ccttcagccc    660

tccacatccc tacattaatc cctacatgga ctatatccgc tccttgcaca gcagcccatc    720

gctctccatg atctcagcaa cccgtgggct gagccctaca gatgcgcccc atgcaggagt    780

cagcccagca gaatactatc atcagatggc cctgctaact ggccagcgca gcccctatgc    840

agacattatt ccctcagctg ccaccgccgg cacgggggcc atccacatgg aatatcttca    900

tgctatggat agcaccagat tctccagccc caggctgtca gccaggccga gccgaaaacg    960

tacactgtcc atatcaccac tctccgatca tagctttgac cttcagacca tgataaggac   1020

gtctcccaac tccttggtca cgattctcaa taattcccgt agcagctctt cagcaagtgg   1080

ctcctatggt cacttatctg caagtgcaat cagccctgcc ttgagcttca cctactcttc   1140

cgcgcccgtc tctctccaca tgcatcagca gatcctaagc cgacaacaga gcttaggttc   1200

agcctttgga cacagccctc cactcatcca ccctgcccca acttttccaa cacagaggcc   1260

tattccaggg atccctacgg ttctgaaccc cgtccaggtc agctccggcc cttctgagtc   1320

ctcacagaac aagcccacga gtgagtctgc agtgagcagc actggtgacc cgatgcacaa   1380

caagaggtcc aagatcaaac ccgatgaaga cctccccagc ccaggggctc gggggcagca   1440

ggaacagccc gaaggaacaa cccttgtcaa ggaggaaggg gacaaagatg aaagcaaaca   1500

ggagcctgaa gtcatctatg agacaaactg ccactgggaa ggctgcgcga gggagttcga   1560

cacccaagag cagcttgtgc accatataaa taacgaccat attcatggag agaagaagga   1620

gttcgtgtgc aggtggctgg actgctcaag agagcagaaa cccttcaaag cccagtatat   1680

gttggtagtg catatgagaa gacacacggg cgagaagcct cacaaatgca cttttgaagg   1740

ttgcacaaag gcctactcga gactagaaaa cttgaaaaca cacttgagat ctcacactgg   1800

agagaaacca tacgtctgtg agcacgaagg ttgcaacaag gctttctcaa atgcctctga   1860

tcgcgccaaa caccaaaaca gaacgcattc caatgagaaa ccatatgtgt gcaaaatccc   1920

aggctgcact aagcgttaca cagacccaag ctccctccgg aaacatgtga agacagtgca   1980

tggcccagag gctcatgtca ccaagaagca gcgaggggac atccatcctc ggccgccacc   2040

cccgagagat tccggcagcc attcacagtc caggtcgcct ggccgaccga ctcagggagc   2100

ccttggtgag cagcaggacc tcagcaacac tacctcaaag cgggaagaat gcctccaggt   2160

gaaaaccgtc aaggcagaga agccaatgac atctcagcca agccctggtg gtcagtcttc   2220

atgcagcagc caacagtccc ccatcagcaa ctattccaac agtgggctcg agcttcctct   2280

gaccgatgga ggtagtatag gagacctcag tgccatcgat gaaaccccaa tcatggactc   2340

aaccatttcc actgcaacca cagcccttgc tttgcaagcc aggagaaacc cggcagggac   2400

caaatggatg gagcacgtaa aactagaaag gctaaaacaa gtgaatggaa tgtttccgcg   2460

actgaacccc attctacccc ctaaagcccc tgcggtctct cctctcatag gaaatggcac   2520

acagtccaac aacacctgca gcttgggtgg gcccatgacg cttctcccgg gcagaagcga   2580

cctctctggg gtggacgtca ctatgctgaa catgctcaac agaagggaca gcagcgccag   2640

caccatcagc tcggcctacc tgagcagccg ccgctcctca gggatctcgc cctgcttctc   2700

cagccgccgc tccagcgagg cgtcacaggc cgagggccgg ccgcagaacg tgagcgtggc   2760

cgactcctac gaccccatct ccaccgacgc ctcgcgccgc tccagcgaag ccagccagag   2820

cgacggcctg cccagcctgc tcagcctcac gcccgcccag cagtaccgcc tcaaggccaa   2880

gtacgcggct gccacaggag ggccgccgcc gacgcccctg cccaacatgg agaggatgag   2940

cctgaagacg cgcctggcgc tgctcgggga tgccctcgag cctggcgtgg ccctgcctcc   3000

agttcatgcc ccgaggaggt gcagcgacgg gggagcccac ggctacgggc ggcgccacct   3060

gcagccgcac gatgcgccgg gccacggcgt gaggagggcc agcgacccgg tgcggacagg   3120

ctccgagggc ctggccctgc ctcgtgtgcc gcgcttcagc agcctcagca gctgcaaccc   3180

cccggcgatg gccacgtccg cggagaagcg cagtctcgtg cttcagaatt acacgcggcc   3240

cgagggcggc cagtcccgaa acttccactc gtccccctgt cctcccagca tcaccgagaa   3300

cgtcaccctg gagtccctga ccatggacgc tgatgccaac ctgaacgatg aggatttcct   3360

gccggacgac gtggtgcagt atttaaattc ccagaaccaa gcagggtacg agcagcactt   3420

ccccagcgcc ctcccggacg acagcaaagt gccccacggg cccggtgact ttgacgcgcc   3480

cgggctgcca gacagccacg ctggccagca gttccatgcc ctcgagcagc cctgccccga   3540

gggcagcaaa accgacctgc ccattcagtg gaacgaagtc agctccggaa gcgccgacct   3600

gtcctcctcc aagctcaagt gtgggccgcg gcccgctgtg ccgcagactc gcgcctttgg   3660

gttctgcaac ggcatggtcg tccacccgca gaaccccttg aggagcgggc ctgctggggg   3720

ctatcagacc ctcggggaga acagcaaccc ctacggtggc ccagagcact tgatgctcca   3780

caacagcccc ggaagtggca ccagtggaaa cgccttccat gaacagccct gtaaggcccc   3840

gcagtatggg aactgtctca acaggcagcc agtggcccct ggtgcactcg acggtgcctg   3900

tggtgccggg attcaagcct caaagctgaa gagcaccccc atgcaaggga gcgggggcca   3960

gctgaatttc ggcctgccgg tagcgccaaa tgagtcagct ggcagcatgg tgaatggcat   4020

gcagaaccag gacccagtgg gacaggggta cctggctcac cagctcctcg gcgacagcat   4080

gcagcacccg ggggcaggcc gccccggtca gcagatgctt gggcagatta gtgctacctc   4140

acacatcaac atctaccaag ggccagagag ctgcctgcca ggggctcacg gcatgggcag   4200

ccagccgtca agcttggcag ttgtcagggg ctaccagcca tgtgccagct ttgggggcag   4260

caggcgccag gctatgccga gggacagcct tgctctgcag tcaggacagc tcagtgacac   4320

aagtcagacc tgcagggtga atggtatcaa gatggagatg aaagggcagc cccatccgct   4380

gtgctctaat ctgcagaatt actctggtca gttctatgac caaaccgtgg gcttcagtca   4440

gcaagacacg aaagctggtt cattctctat ttcagacgcc agctgcctgc tacaggggac   4500

cagcgccaaa aactctgagt tactttcccc aggtgctaat caggtgacaa gcacagtgga   4560

cagcctcgac agccatgacc tggaaggggt acagattgac ttcgatgcca tcatagacga   4620

tggggaccac tccagcctga tgtcgggggc cctgagccca agtatcattc agaacctttc   4680

ccatagctcc tcccgcctca ccacgcctcg ggcgtccctc ccattcccag cgctgtccat   4740

gagcaccacc aacatggcta tcggggacat gagttctttg ctgacctccc tagcggaaga   4800

aagcaaattc cttgcagtta tgcaataggc tttaggaaaa aaagactgca accaacggaa   4860

atcaatagga gttgaagaga ttaaactgac tttgttttgg ctgttttttt agttctgtat   4920

gtattttagc aatctcatct cacctaactg agatgtgttt caattatatt ccttttatgg   4980

aaaaggactc tgaaaaaccc taaagtattc tagggagaaa ctgtcttcca tttcagtttt   5040

gaatcagtat tgttacactc aaaccaccct ctttttaaaa aaaaaaaaaa aaactgtaag   5100

ccccgccccc tttttagtaa accgatgtaa atttgtgatg tgcatattct tctttctttt   5160

agaagagcag tcaaattaaa ggatttgaca tgttttgctg ttgctcaaag gaaataggag   5220

ttggtgtgct tgtgaccaag gggttacact tccagctttt aaaattctcc tttacatgtg   5280

ctcagtgttt tgttttgtgt tttggtttct gttttttatt ttaattccca cattgggcac   5340

aagaatcaga atatggatag ctagtttaag aaacttttgt gggtgcactg tagcatagat   5400

gacagaatat tgatgttccc cccatctcca attcagttca gggcattcca cagttaaaca   5460

gaaatgggaa cgtggggctc ttataaatga aatgggcgct cacagttttg gttttcagct   5520

cttcatgtct gtaagtgtgc tttgggggag gctatgtctg tatggtcgat tctcagttat   5580

cacatttgcc tctcctccca ctaccttcat gaacattcag tgctgtttcg cactgcagtt   5640

agagagaagg gacggacagt tggtgacact cagccacatt gctactttta tctgttctgg   5700

taagaagtta gatagatggt agattgaagc aattgggtag aattagttgg gggaatattt   5760

atgagttgct gtgtttgttg attagttcca tctctttccc attttaactg agaattgatt   5820

atatatagct ctaagtatat aggtatttaa acaaccccac aagcggctgt atcagtaaca   5880

tttattaatt ccactatagt gagggaggat ttccattcta aataccttat tttgagggat   5940

ttataaaact tagttgtaaa agagaaagcc cacatagtgg gaataaattg cttcagccat   6000

ttttagtatt tgagagcact agggaagatg tttagtagct gtgtggatgc cttttttcac   6060

accctgtcta ttgaatgctg catccattca cgaagttaaa tgttacatgc agttagtcct   6120

taatgtggac tggatctgta cttttgtttt ggattaaaac atttaaagat ttttgaagtg   6180

cagctactcc ccacgtgcat ttgatacaca taaaagtcat actgtgtgtg cacaaagagt   6240

acatggattt tccagcatat tgctttaaaa aattatataa actgttaaaa tattaacacc   6300

tcaggctacc tgctgtattc tgtcccattg acccctggaa ttggatttac tgcaagtgat   6360

tgataattca attatgtggc ttttcccctt taatcttgcc atttaaatta cagtagaaag   6420

acaaaatcaa gtaaaataaa gtgttagata atagaaagag tgttaagacc agcccacttt   6480

tctcatgttt atgttctttc atttggacca agaatctccg catggaggtt gatttgccac   6540

tggggacttt ggctaagact attaggtttg ctttcaacta gatgttcctg agacaagcag   6600

agggacactg caattcccct tccatgcctg ctgttctccc ccatgtaagt cttctttgaa   6660

attaacggat gtgtctcctt tggaacagcc ccataacaaa agagaactac tgatctgagc   6720

ataggaaagt agaggctcta ccacttttca gttgaaaaag caagactttc tctgtgtttc   6780

tgaaacaagg cataatgttg tcacagaatc agagatccag tctcactttt ccacaaatct   6840

ccaaatctcc agtcttatct tgtgtgctct aatggtttgg ttcaatccct ttccaactct   6900

tgttttcaaa gcatggggcc tgagtgttct ccactcctcc taagaaagga gcttgggtgg   6960

aagggaccat gctgacctcc tccatcagag ggctcttcca gtagtattct cggatgcaac   7020

ctccatttct cagttaccat tatttcctgt atcagctttg tccttcctgg agggatgcac   7080

agtgatccgg cccaccactg ttgttgtctt gtgcttctgc tctttcctat ggtttcaggt   7140

tattttctgg gtttccccta ttcttctttt atttcttttt ttttttatat ttgctttcct   7200

ttctactgct tttagatttg caggagatgc aagtttcagc tcaatgtttg gcttctctca   7260

atatggaaat ttcagaagga cagaggagag gagggaggaa gaagaaagta tactcctcca   7320

gaatttcagt gatctgttgt ggcagtccag tggaaggaag gtcttttgag gtcacttaga   7380

agcatctttt tgggacatcc ttttgggatc tctgtaggct aggcatctca tatcttgaga   7440

ctcaccccca gcctccaagc ctctctccat ttctctaacc tatgcatttt agagcgagag   7500

gaccgcctca ctagtgtcac catcctgcct tttctaaaac atgcaggctc acacattcta   7560

ctcctgctta atgtctgtgt taaacgtttt ctaaccattt ttgttttatt tttctgaaaa   7620

agttaacccc tcccaactcc tcacacattg gctcttcctc ttgagccaca aagttttgat   7680

tcttgcgatg tatgtgcctt attttatgtt aatcttgtca atgagaggga ccagttggtg   7740

ttgcccaatc agcactccaa ggctgtgtgt gcaccagcca gagagcgcac ggtggtagca   7800

gagtcgaggc tgtcttgtat cctggtttca tgtgttgttt tgaactgata ggaggatgtt   7860

ctcttctgac aagttaccct tgtgtatcct gcagacatgt aaaataaaat acaagttcat   7920

ttttttcacc ttttttagat ttttttaaaa aataaaatgt gtaatccttt ttttaaaaga   7980

aacacatgta aatacattta agtattgtag gcatagcgtt cagatgtgac tggcccaggc   8040

gttcctcgga caagcctgca ttccccgtga tcacgcccac ctcaagccca ggggctgcag   8100

cccagccaca gatgaactct acctttgctt tcagaaccac ttagtccttt tgtaacaaag   8160

aaaaaaaaat gtttcttaca atgtcaataa aaaattcttt gtatggaaa               8209


<210>  418
<211>  1580
<212>  PRT
<213>  Homo sapiens

<400>  418

Met Glu Ala Gln Ser His Ser Ser Thr Thr Thr Glu Lys Lys Lys Val 
1               5                   10                  15


Glu Asn Ser Ile Val Lys Cys Ser Thr Arg Thr Asp Val Ser Glu Lys 
            20                  25                  30


Ala Val Ala Ser Ser Thr Thr Ser Asn Glu Asp Glu Ser Pro Gly Gln 
        35                  40                  45


Thr Tyr His Arg Glu Arg Arg Asn Ala Ile Thr Met Gln Pro Gln Asn 
    50                  55                  60


Val Gln Gly Leu Ser Lys Val Ser Glu Glu Pro Ser Thr Ser Ser Asp 
65                  70                  75                  80


Glu Arg Ala Ser Leu Ile Lys Lys Glu Ile His Gly Ser Leu Pro His 
                85                  90                  95


Val Ala Glu Pro Ser Val Pro Tyr Arg Gly Thr Val Phe Ala Met Asp 
            100                 105                 110


Pro Arg Asn Gly Tyr Met Glu Pro His Tyr His Pro Pro His Leu Phe 
        115                 120                 125


Pro Ala Phe His Pro Pro Val Pro Ile Asp Ala Arg His His Glu Gly 
    130                 135                 140


Arg Tyr His Tyr Asp Pro Ser Pro Ile Pro Pro Leu His Met Thr Ser 
145                 150                 155                 160


Ala Leu Ser Ser Ser Pro Thr Tyr Pro Asp Leu Pro Phe Ile Arg Ile 
                165                 170                 175


Ser Pro His Arg Asn Pro Thr Ala Ala Ser Glu Ser Pro Phe Ser Pro 
            180                 185                 190


Pro His Pro Tyr Ile Asn Pro Tyr Met Asp Tyr Ile Arg Ser Leu His 
        195                 200                 205


Ser Ser Pro Ser Leu Ser Met Ile Ser Ala Thr Arg Gly Leu Ser Pro 
    210                 215                 220


Thr Asp Ala Pro His Ala Gly Val Ser Pro Ala Glu Tyr Tyr His Gln 
225                 230                 235                 240


Met Ala Leu Leu Thr Gly Gln Arg Ser Pro Tyr Ala Asp Ile Ile Pro 
                245                 250                 255


Ser Ala Ala Thr Ala Gly Thr Gly Ala Ile His Met Glu Tyr Leu His 
            260                 265                 270


Ala Met Asp Ser Thr Arg Phe Ser Ser Pro Arg Leu Ser Ala Arg Pro 
        275                 280                 285


Ser Arg Lys Arg Thr Leu Ser Ile Ser Pro Leu Ser Asp His Ser Phe 
    290                 295                 300


Asp Leu Gln Thr Met Ile Arg Thr Ser Pro Asn Ser Leu Val Thr Ile 
305                 310                 315                 320


Leu Asn Asn Ser Arg Ser Ser Ser Ser Ala Ser Gly Ser Tyr Gly His 
                325                 330                 335


Leu Ser Ala Ser Ala Ile Ser Pro Ala Leu Ser Phe Thr Tyr Ser Ser 
            340                 345                 350


Ala Pro Val Ser Leu His Met His Gln Gln Ile Leu Ser Arg Gln Gln 
        355                 360                 365


Ser Leu Gly Ser Ala Phe Gly His Ser Pro Pro Leu Ile His Pro Ala 
    370                 375                 380


Pro Thr Phe Pro Thr Gln Arg Pro Ile Pro Gly Ile Pro Thr Val Leu 
385                 390                 395                 400


Asn Pro Val Gln Val Ser Ser Gly Pro Ser Glu Ser Ser Gln Asn Lys 
                405                 410                 415


Pro Thr Ser Glu Ser Ala Val Ser Ser Thr Gly Asp Pro Met His Asn 
            420                 425                 430


Lys Arg Ser Lys Ile Lys Pro Asp Glu Asp Leu Pro Ser Pro Gly Ala 
        435                 440                 445


Arg Gly Gln Gln Glu Gln Pro Glu Gly Thr Thr Leu Val Lys Glu Glu 
    450                 455                 460


Gly Asp Lys Asp Glu Ser Lys Gln Glu Pro Glu Val Ile Tyr Glu Thr 
465                 470                 475                 480


Asn Cys His Trp Glu Gly Cys Ala Arg Glu Phe Asp Thr Gln Glu Gln 
                485                 490                 495


Leu Val His His Ile Asn Asn Asp His Ile His Gly Glu Lys Lys Glu 
            500                 505                 510


Phe Val Cys Arg Trp Leu Asp Cys Ser Arg Glu Gln Lys Pro Phe Lys 
        515                 520                 525


Ala Gln Tyr Met Leu Val Val His Met Arg Arg His Thr Gly Glu Lys 
    530                 535                 540


Pro His Lys Cys Thr Phe Glu Gly Cys Thr Lys Ala Tyr Ser Arg Leu 
545                 550                 555                 560


Glu Asn Leu Lys Thr His Leu Arg Ser His Thr Gly Glu Lys Pro Tyr 
                565                 570                 575


Val Cys Glu His Glu Gly Cys Asn Lys Ala Phe Ser Asn Ala Ser Asp 
            580                 585                 590


Arg Ala Lys His Gln Asn Arg Thr His Ser Asn Glu Lys Pro Tyr Val 
        595                 600                 605


Cys Lys Ile Pro Gly Cys Thr Lys Arg Tyr Thr Asp Pro Ser Ser Leu 
    610                 615                 620


Arg Lys His Val Lys Thr Val His Gly Pro Glu Ala His Val Thr Lys 
625                 630                 635                 640


Lys Gln Arg Gly Asp Ile His Pro Arg Pro Pro Pro Pro Arg Asp Ser 
                645                 650                 655


Gly Ser His Ser Gln Ser Arg Ser Pro Gly Arg Pro Thr Gln Gly Ala 
            660                 665                 670


Leu Gly Glu Gln Gln Asp Leu Ser Asn Thr Thr Ser Lys Arg Glu Glu 
        675                 680                 685


Cys Leu Gln Val Lys Thr Val Lys Ala Glu Lys Pro Met Thr Ser Gln 
    690                 695                 700


Pro Ser Pro Gly Gly Gln Ser Ser Cys Ser Ser Gln Gln Ser Pro Ile 
705                 710                 715                 720


Ser Asn Tyr Ser Asn Ser Gly Leu Glu Leu Pro Leu Thr Asp Gly Gly 
                725                 730                 735


Ser Ile Gly Asp Leu Ser Ala Ile Asp Glu Thr Pro Ile Met Asp Ser 
            740                 745                 750


Thr Ile Ser Thr Ala Thr Thr Ala Leu Ala Leu Gln Ala Arg Arg Asn 
        755                 760                 765


Pro Ala Gly Thr Lys Trp Met Glu His Val Lys Leu Glu Arg Leu Lys 
    770                 775                 780


Gln Val Asn Gly Met Phe Pro Arg Leu Asn Pro Ile Leu Pro Pro Lys 
785                 790                 795                 800


Ala Pro Ala Val Ser Pro Leu Ile Gly Asn Gly Thr Gln Ser Asn Asn 
                805                 810                 815


Thr Cys Ser Leu Gly Gly Pro Met Thr Leu Leu Pro Gly Arg Ser Asp 
            820                 825                 830


Leu Ser Gly Val Asp Val Thr Met Leu Asn Met Leu Asn Arg Arg Asp 
        835                 840                 845


Ser Ser Ala Ser Thr Ile Ser Ser Ala Tyr Leu Ser Ser Arg Arg Ser 
    850                 855                 860


Ser Gly Ile Ser Pro Cys Phe Ser Ser Arg Arg Ser Ser Glu Ala Ser 
865                 870                 875                 880


Gln Ala Glu Gly Arg Pro Gln Asn Val Ser Val Ala Asp Ser Tyr Asp 
                885                 890                 895


Pro Ile Ser Thr Asp Ala Ser Arg Arg Ser Ser Glu Ala Ser Gln Ser 
            900                 905                 910


Asp Gly Leu Pro Ser Leu Leu Ser Leu Thr Pro Ala Gln Gln Tyr Arg 
        915                 920                 925


Leu Lys Ala Lys Tyr Ala Ala Ala Thr Gly Gly Pro Pro Pro Thr Pro 
    930                 935                 940


Leu Pro Asn Met Glu Arg Met Ser Leu Lys Thr Arg Leu Ala Leu Leu 
945                 950                 955                 960


Gly Asp Ala Leu Glu Pro Gly Val Ala Leu Pro Pro Val His Ala Pro 
                965                 970                 975


Arg Arg Cys Ser Asp Gly Gly Ala His Gly Tyr Gly Arg Arg His Leu 
            980                 985                 990


Gln Pro His Asp Ala Pro Gly His Gly Val Arg Arg Ala Ser Asp Pro 
        995                 1000                1005


Val Arg Thr Gly Ser Glu Gly Leu Ala Leu Pro Arg Val Pro Arg Phe 
    1010                1015                1020


Ser Ser Leu Ser Ser Cys Asn Pro Pro Ala Met Ala Thr Ser Ala Glu 
1025                1030                1035                1040


Lys Arg Ser Leu Val Leu Gln Asn Tyr Thr Arg Pro Glu Gly Gly Gln 
                1045                1050                1055


Ser Arg Asn Phe His Ser Ser Pro Cys Pro Pro Ser Ile Thr Glu Asn 
            1060                1065                1070


Val Thr Leu Glu Ser Leu Thr Met Asp Ala Asp Ala Asn Leu Asn Asp 
        1075                1080                1085


Glu Asp Phe Leu Pro Asp Asp Val Val Gln Tyr Leu Asn Ser Gln Asn 
    1090                1095                1100


Gln Ala Gly Tyr Glu Gln His Phe Pro Ser Ala Leu Pro Asp Asp Ser 
1105                1110                1115                1120


Lys Val Pro His Gly Pro Gly Asp Phe Asp Ala Pro Gly Leu Pro Asp 
                1125                1130                1135


Ser His Ala Gly Gln Gln Phe His Ala Leu Glu Gln Pro Cys Pro Glu 
            1140                1145                1150


Gly Ser Lys Thr Asp Leu Pro Ile Gln Trp Asn Glu Val Ser Ser Gly 
        1155                1160                1165


Ser Ala Asp Leu Ser Ser Ser Lys Leu Lys Cys Gly Pro Arg Pro Ala 
    1170                1175                1180


Val Pro Gln Thr Arg Ala Phe Gly Phe Cys Asn Gly Met Val Val His 
1185                1190                1195                1200


Pro Gln Asn Pro Leu Arg Ser Gly Pro Ala Gly Gly Tyr Gln Thr Leu 
                1205                1210                1215


Gly Glu Asn Ser Asn Pro Tyr Gly Gly Pro Glu His Leu Met Leu His 
            1220                1225                1230


Asn Ser Pro Gly Ser Gly Thr Ser Gly Asn Ala Phe His Glu Gln Pro 
        1235                1240                1245


Cys Lys Ala Pro Gln Tyr Gly Asn Cys Leu Asn Arg Gln Pro Val Ala 
    1250                1255                1260


Pro Gly Ala Leu Asp Gly Ala Cys Gly Ala Gly Ile Gln Ala Ser Lys 
1265                1270                1275                1280


Leu Lys Ser Thr Pro Met Gln Gly Ser Gly Gly Gln Leu Asn Phe Gly 
                1285                1290                1295


Leu Pro Val Ala Pro Asn Glu Ser Ala Gly Ser Met Val Asn Gly Met 
            1300                1305                1310


Gln Asn Gln Asp Pro Val Gly Gln Gly Tyr Leu Ala His Gln Leu Leu 
        1315                1320                1325


Gly Asp Ser Met Gln His Pro Gly Ala Gly Arg Pro Gly Gln Gln Met 
    1330                1335                1340


Leu Gly Gln Ile Ser Ala Thr Ser His Ile Asn Ile Tyr Gln Gly Pro 
1345                1350                1355                1360


Glu Ser Cys Leu Pro Gly Ala His Gly Met Gly Ser Gln Pro Ser Ser 
                1365                1370                1375


Leu Ala Val Val Arg Gly Tyr Gln Pro Cys Ala Ser Phe Gly Gly Ser 
            1380                1385                1390


Arg Arg Gln Ala Met Pro Arg Asp Ser Leu Ala Leu Gln Ser Gly Gln 
        1395                1400                1405


Leu Ser Asp Thr Ser Gln Thr Cys Arg Val Asn Gly Ile Lys Met Glu 
    1410                1415                1420


Met Lys Gly Gln Pro His Pro Leu Cys Ser Asn Leu Gln Asn Tyr Ser 
1425                1430                1435                1440


Gly Gln Phe Tyr Asp Gln Thr Val Gly Phe Ser Gln Gln Asp Thr Lys 
                1445                1450                1455


Ala Gly Ser Phe Ser Ile Ser Asp Ala Ser Cys Leu Leu Gln Gly Thr 
            1460                1465                1470


Ser Ala Lys Asn Ser Glu Leu Leu Ser Pro Gly Ala Asn Gln Val Thr 
        1475                1480                1485


Ser Thr Val Asp Ser Leu Asp Ser His Asp Leu Glu Gly Val Gln Ile 
    1490                1495                1500


Asp Phe Asp Ala Ile Ile Asp Asp Gly Asp His Ser Ser Leu Met Ser 
1505                1510                1515                1520


Gly Ala Leu Ser Pro Ser Ile Ile Gln Asn Leu Ser His Ser Ser Ser 
                1525                1530                1535


Arg Leu Thr Thr Pro Arg Ala Ser Leu Pro Phe Pro Ala Leu Ser Met 
            1540                1545                1550


Ser Thr Thr Asn Met Ala Ile Gly Asp Met Ser Ser Leu Leu Thr Ser 
        1555                1560                1565


Leu Ala Glu Glu Ser Lys Phe Leu Ala Val Met Gln 
    1570                1575                1580


<210>  419
<211>  3259
<212>  DNA
<213>  Homo sapiens

<400>  419
ggggcagggc gggggcggtg gggcctcccc tagccttccc tccccctctc cttcactgtc     60

cttccagcag gcacaggaag gtgaggcaag gtgtttccag ccggcaggat ggaggacgag    120

gaaggccctg agtatggcaa acctgacttt gtgcttttgg accaagtgac catggaggac    180

ttcatgagga acctgcagct caggttcgag aagggccgca tctacaccta catcggtgag    240

gtgctggtgt ccgtgaaccc ctaccaggag ctgcccctgt atgggcctga ggccatcgcc    300

aggtaccagg gccgtgagct ctatgagcgg ccaccccatc tctatgctgt ggccaacgcc    360

gcctacaagg caatgaagca ccggtccagg gacacctgca tcgtcatctc aggggagagt    420

ggggcaggga agacagaagc cagtaagcac atcatgcagt acatcgctgc tgtcaccaat    480

ccaagccaga gggctgaggt ggagagggtc aaggacgtgc tgctcaagtc cacctgtgtg    540

ctggaggcct ttggcaatgc ccgcaccaac cgcaatcaca actccagccg ctttggcaag    600

tacatggaca tcaactttga cttcaagggg gacccgatcg gaggacacat ccacagctac    660

ctactggaga agtctcgggt cctcaagcag cacgtgggtg aaagaaactt ccacgccttc    720

taccaattgc tgagaggcag tgaggacaag cagctgcatg aactgcactt ggagagaaac    780

cctgctgtat acaatttcac acaccaggga gcaggactca acatgactgt gcacagtgcc    840

ttggacagtg atgagcagag ccaccaggca gtgaccgagg ccatgagggt catcggcttc    900

agtcctgaag aggtggagtc tgtgcatcgc atcctggctg ccatattgca cctgggaaac    960

atcgagtttg tggagacgga ggagggtggg ctgcagaagg agggcctggc agtggccgag   1020

gaggcactgg tggaccatgt ggctgagctg acggccacac cccgggacct cgtgctccgc   1080

tccctgctgg ctcgcacagt tgcctcggga ggcagggaac tcatagagaa gggccacact   1140

gcagctgagg ccagctatgc ccgggatgcc tgtgccaagg cagtgtacca gcggctgttt   1200

gagtgggtgg tgaacaggat caacagtgtc atggaacccc ggggccggga tcctcggcgt   1260

gatggcaagg acacagtcat tggcgtgctg gacatctatg gcttcgaggt gtttcccgtc   1320

aacagtttcg agcagttctg catcaactac tgcaacgaga agctgcagca gctattcatc   1380

cagctcatcc tgaagcagga acaggaagag tacgagcgcg agggcatcac ctggcagagc   1440

gttgagtatt tcaacaacgc caccattgtg gatctggtgg agcggcccca ccgtggcatc   1500

ctggccgtgc tggacgaggc ctgcagctct gctggcacca tcactgaccg aatcttcctg   1560

cagaccctgg acacgcacca ccgccatcac ctacactaca ccagccgcca gctctgcccc   1620

acagacaaga ccatggagtt tggccgagac ttccggatca agcactatgc aggggacgtc   1680

acgtactccg tggaaggctt catcgacaag aacagagatt tcctcttcca ggacttcaag   1740

cggctgctgt acaacagcac ggaccccact ctacgggcca tgtggccgga cgggcagcag   1800

gacatcacag aggtgaccaa gcgccccctg acggctggca cactcttcaa gaactccatg   1860

gtggccctgg tggagaacct tgcctccaag gagcccttct acgtccgctg catcaagccc   1920

aatgaggaca aggtagctgg gaagctggat gagaaccact gtcgccacca ggtcgcatac   1980

ctggggctgc tggagaatgt gagggtccgc agggctggct tcgcttcccg ccagccctac   2040

tctcgattcc tgctcaggta caagatgacc tgtgaataca catggcccaa ccacctgctg   2100

ggctccgaca aggcagccgt gagcgctctc ctggagcagc acgggctgca gggggacgtg   2160

gcctttggcc acagcaagct gttcatccgc tcaccccgga cactggtcac actggagcag   2220

agccgagccc gcctcatccc catcattgtg ctgctattgc agaaggcatg gcggggcacc   2280

ttggcgaggt ggcgctgccg gaggctgagg gctatctaca ccatcatgcg ctggttccgg   2340

agacacaagg tgcgggctca cctggctgag ctgcagcggc gattccaggc tgcaaggcag   2400

ccgccactct acgggcgtga ccttgtgtgg ccgctgcccc ctgctgtgct gcagcccttc   2460

caggacacct gccacgcact cttctgcagg tggcgggccc ggcagctggt gaagaacatc   2520

cccccttcag acatgcccca gatcaaggcc aaggtggccg ccatgggggc cctgcaaggg   2580

cttcgtcagg actggggctg ccgacgggcc tgggcccgag actacctgtc ctctgccact   2640

gacaatccca cagcatcaag cctgtttgct cagcgactaa agacacttcg ggacaaagat   2700

ggcttcgggg ctgtgctctt ttcaagccat gtccgcaagg tgaaccgctt ccacaagatc   2760

cggaaccggg ccctcctgct cacagaccag cacctctaca agctggaccc tgaccggcag   2820

taccgggtga tgcgggccgt gccccttgag gcggtgacgg ggctgagcgt gaccagcgga   2880

ggagaccagc tggtggtgct gcacgcccgc ggccaggacg acctcgtggt gtgcctgcac   2940

cgctcccggc cgccattgga caaccgcgtt ggggagctgg tgggcgtgct ggccgcacac   3000

tgccaggggg agggccgcac cctggaggtt cgcgtctccg actgcatccc actaagccat   3060

cgcggggtcc ggcgcctcat ctccgtggag cccaggccgg agcagccaga gcccgatttc   3120

cgctgcgctc gcggctcctt caccctgctc tggcccagcc gctgagcgcc cgcacccgcc   3180

gcaccccgag gccgccaatt gtccgccccg ccagcgctgc aaataaacct tctgagtcag   3240

ccaaaaaaaa aaaaaaaaa                                                3259


<210>  420
<211>  1018
<212>  PRT
<213>  Homo sapiens

<400>  420

Met Glu Asp Glu Glu Gly Pro Glu Tyr Gly Lys Pro Asp Phe Val Leu 
1               5                   10                  15


Leu Asp Gln Val Thr Met Glu Asp Phe Met Arg Asn Leu Gln Leu Arg 
            20                  25                  30


Phe Glu Lys Gly Arg Ile Tyr Thr Tyr Ile Gly Glu Val Leu Val Ser 
        35                  40                  45


Val Asn Pro Tyr Gln Glu Leu Pro Leu Tyr Gly Pro Glu Ala Ile Ala 
    50                  55                  60


Arg Tyr Gln Gly Arg Glu Leu Tyr Glu Arg Pro Pro His Leu Tyr Ala 
65                  70                  75                  80


Val Ala Asn Ala Ala Tyr Lys Ala Met Lys His Arg Ser Arg Asp Thr 
                85                  90                  95


Cys Ile Val Ile Ser Gly Glu Ser Gly Ala Gly Lys Thr Glu Ala Ser 
            100                 105                 110


Lys His Ile Met Gln Tyr Ile Ala Ala Val Thr Asn Pro Ser Gln Arg 
        115                 120                 125


Ala Glu Val Glu Arg Val Lys Asp Val Leu Leu Lys Ser Thr Cys Val 
    130                 135                 140


Leu Glu Ala Phe Gly Asn Ala Arg Thr Asn Arg Asn His Asn Ser Ser 
145                 150                 155                 160


Arg Phe Gly Lys Tyr Met Asp Ile Asn Phe Asp Phe Lys Gly Asp Pro 
                165                 170                 175


Ile Gly Gly His Ile His Ser Tyr Leu Leu Glu Lys Ser Arg Val Leu 
            180                 185                 190


Lys Gln His Val Gly Glu Arg Asn Phe His Ala Phe Tyr Gln Leu Leu 
        195                 200                 205


Arg Gly Ser Glu Asp Lys Gln Leu His Glu Leu His Leu Glu Arg Asn 
    210                 215                 220


Pro Ala Val Tyr Asn Phe Thr His Gln Gly Ala Gly Leu Asn Met Thr 
225                 230                 235                 240


Val His Ser Ala Leu Asp Ser Asp Glu Gln Ser His Gln Ala Val Thr 
                245                 250                 255


Glu Ala Met Arg Val Ile Gly Phe Ser Pro Glu Glu Val Glu Ser Val 
            260                 265                 270


His Arg Ile Leu Ala Ala Ile Leu His Leu Gly Asn Ile Glu Phe Val 
        275                 280                 285


Glu Thr Glu Glu Gly Gly Leu Gln Lys Glu Gly Leu Ala Val Ala Glu 
    290                 295                 300


Glu Ala Leu Val Asp His Val Ala Glu Leu Thr Ala Thr Pro Arg Asp 
305                 310                 315                 320


Leu Val Leu Arg Ser Leu Leu Ala Arg Thr Val Ala Ser Gly Gly Arg 
                325                 330                 335


Glu Leu Ile Glu Lys Gly His Thr Ala Ala Glu Ala Ser Tyr Ala Arg 
            340                 345                 350


Asp Ala Cys Ala Lys Ala Val Tyr Gln Arg Leu Phe Glu Trp Val Val 
        355                 360                 365


Asn Arg Ile Asn Ser Val Met Glu Pro Arg Gly Arg Asp Pro Arg Arg 
    370                 375                 380


Asp Gly Lys Asp Thr Val Ile Gly Val Leu Asp Ile Tyr Gly Phe Glu 
385                 390                 395                 400


Val Phe Pro Val Asn Ser Phe Glu Gln Phe Cys Ile Asn Tyr Cys Asn 
                405                 410                 415


Glu Lys Leu Gln Gln Leu Phe Ile Gln Leu Ile Leu Lys Gln Glu Gln 
            420                 425                 430


Glu Glu Tyr Glu Arg Glu Gly Ile Thr Trp Gln Ser Val Glu Tyr Phe 
        435                 440                 445


Asn Asn Ala Thr Ile Val Asp Leu Val Glu Arg Pro His Arg Gly Ile 
    450                 455                 460


Leu Ala Val Leu Asp Glu Ala Cys Ser Ser Ala Gly Thr Ile Thr Asp 
465                 470                 475                 480


Arg Ile Phe Leu Gln Thr Leu Asp Thr His His Arg His His Leu His 
                485                 490                 495


Tyr Thr Ser Arg Gln Leu Cys Pro Thr Asp Lys Thr Met Glu Phe Gly 
            500                 505                 510


Arg Asp Phe Arg Ile Lys His Tyr Ala Gly Asp Val Thr Tyr Ser Val 
        515                 520                 525


Glu Gly Phe Ile Asp Lys Asn Arg Asp Phe Leu Phe Gln Asp Phe Lys 
    530                 535                 540


Arg Leu Leu Tyr Asn Ser Thr Asp Pro Thr Leu Arg Ala Met Trp Pro 
545                 550                 555                 560


Asp Gly Gln Gln Asp Ile Thr Glu Val Thr Lys Arg Pro Leu Thr Ala 
                565                 570                 575


Gly Thr Leu Phe Lys Asn Ser Met Val Ala Leu Val Glu Asn Leu Ala 
            580                 585                 590


Ser Lys Glu Pro Phe Tyr Val Arg Cys Ile Lys Pro Asn Glu Asp Lys 
        595                 600                 605


Val Ala Gly Lys Leu Asp Glu Asn His Cys Arg His Gln Val Ala Tyr 
    610                 615                 620


Leu Gly Leu Leu Glu Asn Val Arg Val Arg Arg Ala Gly Phe Ala Ser 
625                 630                 635                 640


Arg Gln Pro Tyr Ser Arg Phe Leu Leu Arg Tyr Lys Met Thr Cys Glu 
                645                 650                 655


Tyr Thr Trp Pro Asn His Leu Leu Gly Ser Asp Lys Ala Ala Val Ser 
            660                 665                 670


Ala Leu Leu Glu Gln His Gly Leu Gln Gly Asp Val Ala Phe Gly His 
        675                 680                 685


Ser Lys Leu Phe Ile Arg Ser Pro Arg Thr Leu Val Thr Leu Glu Gln 
    690                 695                 700


Ser Arg Ala Arg Leu Ile Pro Ile Ile Val Leu Leu Leu Gln Lys Ala 
705                 710                 715                 720


Trp Arg Gly Thr Leu Ala Arg Trp Arg Cys Arg Arg Leu Arg Ala Ile 
                725                 730                 735


Tyr Thr Ile Met Arg Trp Phe Arg Arg His Lys Val Arg Ala His Leu 
            740                 745                 750


Ala Glu Leu Gln Arg Arg Phe Gln Ala Ala Arg Gln Pro Pro Leu Tyr 
        755                 760                 765


Gly Arg Asp Leu Val Trp Pro Leu Pro Pro Ala Val Leu Gln Pro Phe 
    770                 775                 780


Gln Asp Thr Cys His Ala Leu Phe Cys Arg Trp Arg Ala Arg Gln Leu 
785                 790                 795                 800


Val Lys Asn Ile Pro Pro Ser Asp Met Pro Gln Ile Lys Ala Lys Val 
                805                 810                 815


Ala Ala Met Gly Ala Leu Gln Gly Leu Arg Gln Asp Trp Gly Cys Arg 
            820                 825                 830


Arg Ala Trp Ala Arg Asp Tyr Leu Ser Ser Ala Thr Asp Asn Pro Thr 
        835                 840                 845


Ala Ser Ser Leu Phe Ala Gln Arg Leu Lys Thr Leu Arg Asp Lys Asp 
    850                 855                 860


Gly Phe Gly Ala Val Leu Phe Ser Ser His Val Arg Lys Val Asn Arg 
865                 870                 875                 880


Phe His Lys Ile Arg Asn Arg Ala Leu Leu Leu Thr Asp Gln His Leu 
                885                 890                 895


Tyr Lys Leu Asp Pro Asp Arg Gln Tyr Arg Val Met Arg Ala Val Pro 
            900                 905                 910


Leu Glu Ala Val Thr Gly Leu Ser Val Thr Ser Gly Gly Asp Gln Leu 
        915                 920                 925


Val Val Leu His Ala Arg Gly Gln Asp Asp Leu Val Val Cys Leu His 
    930                 935                 940


Arg Ser Arg Pro Pro Leu Asp Asn Arg Val Gly Glu Leu Val Gly Val 
945                 950                 955                 960


Leu Ala Ala His Cys Gln Gly Glu Gly Arg Thr Leu Glu Val Arg Val 
                965                 970                 975


Ser Asp Cys Ile Pro Leu Ser His Arg Gly Val Arg Arg Leu Ile Ser 
            980                 985                 990


Val Glu Pro Arg Pro Glu Gln Pro Glu Pro Asp Phe Arg Cys Ala Arg 
        995                 1000                1005


Gly Ser Phe Thr Leu Leu Trp Pro Ser Arg 
    1010                1015


<210>  421
<211>  133
<212>  DNA
<213>  Homo sapiens

<400>  421
tagcaagcct ccagcgtgct tgggtctgcg gtgaccctat gcattccttc agtgcttgct     60

agaacagttt tgaaacggtt tgaggccttg ccctgctcca tccagagcaa ggttatagaa    120

atttcagaca atg                                                       133


<210>  422
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  422
atgctcgacc cgggcccgcc gcccccgcgc tcccggcgcc gcccgccagc cgggcccgaa     60

gtctccgccc cggccgcgcc ccacacccgc acttccgggc ccgagccccc tccgccccgc    120

ccaggcccca ccttccccag cgcaggcccc gcccacggtt gtcgctcatc ctcactttca    180

ggcccaaggg aatccgaccc gcagcgatca gaccccgccc cttcagggag aacacggccc    240

gttggccccg ctcacggcga gagcaccgcc cacaggctga agatcctgcc ccttcaggac    300

ggccgagaac gcgcctgcct tgcaccaccc ccaccccgcc ccgcgtcctt caggagagcc    360

ggaaacgctc ctacccctac ttcgcttctg cacggccgcg agaacgcacc tgtccagccc    420

cctgttcgct ccgcccactc agcgcgcgcg ggagcgcgcg cgggagcagc tccaactttt    480

tcaatttgcc gccatcttta cggcggccga cttcccagcc tgcctcgcgt ccagggaggc    540

ggagctcagg caggctcctg ttcattccca aggctccgtg tccacatcgt gcttggattc    600

cgcccggccc cgcctgtgcg gccgcaccag gaaggcacca cccattag                 648


<210>  423
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  423

Met Leu Asp Pro Gly Pro Pro Pro Pro Arg Ser Arg Arg Arg Pro Pro 
1               5                   10                  15


Ala Gly Pro Glu Val Ser Ala Pro Ala Ala Pro His Thr Arg Thr Ser 
            20                  25                  30


Gly Pro Glu Pro Pro Pro Pro Arg Pro Gly Pro Thr Phe Pro Ser Ala 
        35                  40                  45


Gly Pro Ala His Gly Cys Arg Ser Ser Ser Leu Ser Gly Pro Arg Glu 
    50                  55                  60


Ser Asp Pro Gln Arg Ser Asp Pro Ala Pro Ser Gly Arg Thr Arg Pro 
65                  70                  75                  80


Val Gly Pro Ala His Gly Glu Ser Thr Ala His Arg Leu Lys Ile Leu 
                85                  90                  95


Pro Leu Gln Asp Gly Arg Glu Arg Ala Cys Leu Ala Pro Pro Pro Pro 
            100                 105                 110


Arg Pro Ala Ser Phe Arg Arg Ala Gly Asn Ala Pro Thr Pro Thr Ser 
        115                 120                 125


Leu Leu His Gly Arg Glu Asn Ala Pro Val Gln Pro Pro Val Arg Ser 
    130                 135                 140


Ala His Ser Ala Arg Ala Gly Ala Arg Ala Gly Ala Ala Pro Thr Phe 
145                 150                 155                 160


Ser Ile Cys Arg His Leu Tyr Gly Gly Arg Leu Pro Ser Leu Pro Arg 
                165                 170                 175


Val Gln Gly Gly Gly Ala Gln Ala Gly Ser Cys Ser Phe Pro Arg Leu 
            180                 185                 190


Arg Val His Ile Val Leu Gly Phe Arg Pro Ala Pro Pro Val Arg Pro 
        195                 200                 205


His Gln Glu Gly Thr Thr His 
    210                 215


<210>  424
<211>  2140
<212>  DNA
<213>  Homo sapiens

<400>  424
tttgaaatta atgtccttct gttgactgca gaatttctgc tggaaatgca gggaggctgc     60

ttgtggggtt cgcgtgctgt gggaagtagg gaaaatgagc tggtttactt tgtgtctttt    120

tgtgcatgca gactgtttgg attttgccaa cagtttctgg gtgctgcctg ctttttaaac    180

ttttaaaaaa ttgtaaacag cttcagtggc tttgcagaag gaagctgtgg tttctggtct    240

tcctgttcag tcatgttttt ttcagaggga gggctaacat ctggccatat ttttcaacaa    300

attcagaagt gagtagagaa tgcatagtag ctgtcggcag aggaggaacc agaatctctc    360

caaagaaatt cctcaaacag aatttcacac agggtattcc atggagaatg agcctggaat    420

tgtctcgcca tttaaacgag tattcctaaa aggtgaaaag agtagagata agaaagccca    480

tgagaaggtg acagagaggc gccctctgca cactgtggtg ttgtcattgc ctgagcgcgt    540

cgagccagac agactgctga gcgactatat tgagaaggag gtaaagtatt taggtcagtt    600

aacgtccata ccaggatacc tgaatccctc cagtaggact gaaatcctgc atttcataga    660

caatgcaaag agagcccacc agcttccggg acacttgact caggagcacg atgctgtgct    720

cagcctgtct gcgtacaacg tcaagctggc ctggagggac ggggaggata tcatcctcag    780

ggtgcccatc catgacatcg ccgccgtctc ctatgttcgg gatgacgctg cacacctggt    840

ggtcctgaag acagcccagg acccagggat ctcccccagc cagagtctgt gtgcggaaag    900

ttccagaggc ctcagtgcag gctccctgtc ggagagtgca gttgggcccg tggaggcatg    960

ctgcctggtc atcctggctg cagagagcaa ggtcgctgcg gaggagcttt gctgtctgct   1020

aggccaggtc ttccaggttg tttacacgga gtccaccatc gactttctgg acagagcgat   1080

atttgatggg gcctctaccc cgacccacca cctgtccctg cacagcgatg actcttctac   1140

aaaagtggac attaaggaga cctacgaggt ggaagccagc actttctgct tccctgaatc   1200

tgtggatgtg ggtggtgcat caccccacag caagaccatc agtgagagcg agctgagcgc   1260

cagcgccact gagctgctgc aggactacat gctgacgctg cgcaccaagc tgtcatcaca   1320

ggagatccag cagtttgcag cactgctgca cgagtaccgc aatggggcct ctatccacga   1380

gttctgcatc aacctgcggc agctctacgg ggacagccgc aagttcctgc tgcttggtct   1440

gaggcccttc atccctgaga aggacagcca gcacttcgag aacttcctgg agaccattgg   1500

cgtgaaggat ggccgcggca tcatcactga cagctttggc aggcaccggc gggccctgag   1560

caccacatcc agttccacca ccaatgggaa cagggccacg ggcagctctg atgaccggtc   1620

ggcaccctca gagggggatg agtgggaccg catgatctcg gacatcagca gcgacattga   1680

ggcgctgggc tgcagcatgg accaggactc agcatgatgg acagtggatg ggggggcacc   1740

cacaccttcc gcgcagtcgt cataggcctt cccagaagga gctgcccaga cctgcgtgtc   1800

agcccttggt ggtggccagg gagaggcgcc cggtgcagat ggccccgggc ggcccaggtc   1860

ctctactgtg aaggagcagg gagctgccga gggacacgag cctcagtgcg gggtggaagg   1920

ctctttgcct tgtccaccag ggctcagcca agccctgcag tgtgtccccg ctcggggagg   1980

gcccggccga gcgggcaggg agagccagtc ctgtcggctg ggcccttgga cggctgtcag   2040

ttttgcacat gatgttccta ttgtaactct cagagacctt aaaaagaagt ttactgcaat   2100

gtgaataatt taatctctgg ttgccaagca aaaaaaaaaa                         2140


<210>  425
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  425

Met His Ser Ser Cys Arg Gln Arg Arg Asn Gln Asn Leu Ser Lys Glu 
1               5                   10                  15


Ile Pro Gln Thr Glu Phe His Thr Gly Tyr Ser Met Glu Asn Glu Pro 
            20                  25                  30


Gly Ile Val Ser Pro Phe Lys Arg Val Phe Leu Lys Gly Glu Lys Ser 
        35                  40                  45


Arg Asp Lys Lys Ala His Glu Lys Val Thr Glu Arg Arg Pro Leu His 
    50                  55                  60


Thr Val Val Leu Ser Leu Pro Glu Arg Val Glu Pro Asp Arg Leu Leu 
65                  70                  75                  80


Ser Asp Tyr Ile Glu Lys Glu Val Lys Tyr Leu Gly Gln Leu Thr Ser 
                85                  90                  95


Ile Pro Gly Tyr Leu Asn Pro Ser Ser Arg Thr Glu Ile Leu His Phe 
            100                 105                 110


Ile Asp Asn Ala Lys Arg Ala His Gln Leu Pro Gly His Leu Thr Gln 
        115                 120                 125


Glu His Asp Ala Val Leu Ser Leu Ser Ala Tyr Asn Val Lys Leu Ala 
    130                 135                 140


Trp Arg Asp Gly Glu Asp Ile Ile Leu Arg Val Pro Ile His Asp Ile 
145                 150                 155                 160


Ala Ala Val Ser Tyr Val Arg Asp Asp Ala Ala His Leu Val Val Leu 
                165                 170                 175


Lys Thr Ala Gln Asp Pro Gly Ile Ser Pro Ser Gln Ser Leu Cys Ala 
            180                 185                 190


Glu Ser Ser Arg Gly Leu Ser Ala Gly Ser Leu Ser Glu Ser Ala Val 
        195                 200                 205


Gly Pro Val Glu Ala Cys Cys Leu Val Ile Leu Ala Ala Glu Ser Lys 
    210                 215                 220


Val Ala Ala Glu Glu Leu Cys Cys Leu Leu Gly Gln Val Phe Gln Val 
225                 230                 235                 240


Val Tyr Thr Glu Ser Thr Ile Asp Phe Leu Asp Arg Ala Ile Phe Asp 
                245                 250                 255


Gly Ala Ser Thr Pro Thr His His Leu Ser Leu His Ser Asp Asp Ser 
            260                 265                 270


Ser Thr Lys Val Asp Ile Lys Glu Thr Tyr Glu Val Glu Ala Ser Thr 
        275                 280                 285


Phe Cys Phe Pro Glu Ser Val Asp Val Gly Gly Ala Ser Pro His Ser 
    290                 295                 300


Lys Thr Ile Ser Glu Ser Glu Leu Ser Ala Ser Ala Thr Glu Leu Leu 
305                 310                 315                 320


Gln Asp Tyr Met Leu Thr Leu Arg Thr Lys Leu Ser Ser Gln Glu Ile 
                325                 330                 335


Gln Gln Phe Ala Ala Leu Leu His Glu Tyr Arg Asn Gly Ala Ser Ile 
            340                 345                 350


His Glu Phe Cys Ile Asn Leu Arg Gln Leu Tyr Gly Asp Ser Arg Lys 
        355                 360                 365


Phe Leu Leu Leu Gly Leu Arg Pro Phe Ile Pro Glu Lys Asp Ser Gln 
    370                 375                 380


His Phe Glu Asn Phe Leu Glu Thr Ile Gly Val Lys Asp Gly Arg Gly 
385                 390                 395                 400


Ile Ile Thr Asp Ser Phe Gly Arg His Arg Arg Ala Leu Ser Thr Thr 
                405                 410                 415


Ser Ser Ser Thr Thr Asn Gly Asn Arg Ala Thr Gly Ser Ser Asp Asp 
            420                 425                 430


Arg Ser Ala Pro Ser Glu Gly Asp Glu Trp Asp Arg Met Ile Ser Asp 
        435                 440                 445


Ile Ser Ser Asp Ile Glu Ala Leu Gly Cys Ser Met Asp Gln Asp Ser 
    450                 455                 460


Ala 
465


<210>  426
<211>  1904
<212>  DNA
<213>  Homo sapiens

<400>  426
gcgcggccgg ggcggagact tcgggcccgg ctggcgggcg gcgccgggag cgcgggggcg     60

gcgggcccgg gtcgagcatg tagcggctgc tggcggcggg gctcccgggg cgggccgggc    120

gggccgcggg agccgcacgc ggcgatatgg aagaggaggg caagaagggc aagaagcctg    180

gaattgtctc gccatttaaa cgagtattcc taaaaggtga aaagagtaga gataagaaag    240

cccatgagaa ggtgacagag aggcgccctc tgcacactgt ggtgttgtca ttgcctgagc    300

gcgtcgagcc agacagactg ctgagcgact atattgagaa ggaggtaaag tatttaggtc    360

agttaacgtc cataccagga tacctgaatc cctccagtag gactgaaatc ctgcatttca    420

tagacaatgc aaagagagcc caccagcttc cgggacactt gactcaggag cacgatgctg    480

tgctcagcct gtctgcgtac aacgtcaagc tggcctggag ggacggggag gatatcatcc    540

tcagggtgcc catccatgac atcgccgccg tctcctatgt tcgggatgac gctgcacacc    600

tggtggtcct gaagacagcc caggacccag ggatctcccc cagccagagt ctgtgtgcgg    660

aaagttccag aggcctcagt gcaggctccc tgtcggagag tgcagttggg cccgtggagg    720

catgctgcct ggtcatcctg gctgcagaga gcaaggtcgc tgcggaggag ctttgctgtc    780

tgctaggcca ggtcttccag gttgtttaca cggagtccac catcgacttt ctggacagag    840

cgatatttga tggggcctct accccgaccc accacctgtc cctgcacagc gatgactctt    900

ctacaaaagt ggacattaag gagacctacg aggtggaagc cagcactttc tgcttccctg    960

aatctgtgga tgtgggtggt gcatcacccc acagcaagac catcagtgag agcgagctga   1020

gcgccagcgc cactgagctg ctgcaggact acatgctgac gctgcgcacc aagctgtcat   1080

cacaggagat ccagcagttt gcagcactgc tgcacgagta ccgcaatggg gcctctatcc   1140

acgagttctg catcaacctg cggcagctct acggggacag ccgcaagttc ctgctgcttg   1200

gtctgaggcc cttcatccct gagaaggaca gccagcactt cgagaacttc ctggagacca   1260

ttggcgtgaa ggatggccgc ggcatcatca ctgacagctt tggcaggcac cggcgggccc   1320

tgagcaccac atccagttcc accaccaatg ggaacagggc cacgggcagc tctgatgacc   1380

ggtcggcacc ctcagagggg gatgagtggg accgcatgat ctcggacatc agcagcgaca   1440

ttgaggcgct gggctgcagc atggaccagg actcagcatg atggacagtg gatggggggg   1500

cacccacacc ttccgcgcag tcgtcatagg ccttcccaga aggagctgcc cagacctgcg   1560

tgtcagccct tggtggtggc cagggagagg cgcccggtgc agatggcccc gggcggccca   1620

ggtcctctac tgtgaaggag cagggagctg ccgagggaca cgagcctcag tgcggggtgg   1680

aaggctcttt gccttgtcca ccagggctca gccaagccct gcagtgtgtc cccgctcggg   1740

gagggcccgg ccgagcgggc agggagagcc agtcctgtcg gctgggccct tggacggctg   1800

tcagttttgc acatgatgtt cctattgtaa ctctcagaga ccttaaaaag aagtttactg   1860

caatgtgaat aatttaatct ctggttgcca agcaaaaaaa aaaa                    1904


<210>  427
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  427

Met Glu Glu Glu Gly Lys Lys Gly Lys Lys Pro Gly Ile Val Ser Pro 
1               5                   10                  15


Phe Lys Arg Val Phe Leu Lys Gly Glu Lys Ser Arg Asp Lys Lys Ala 
            20                  25                  30


His Glu Lys Val Thr Glu Arg Arg Pro Leu His Thr Val Val Leu Ser 
        35                  40                  45


Leu Pro Glu Arg Val Glu Pro Asp Arg Leu Leu Ser Asp Tyr Ile Glu 
    50                  55                  60


Lys Glu Val Lys Tyr Leu Gly Gln Leu Thr Ser Ile Pro Gly Tyr Leu 
65                  70                  75                  80


Asn Pro Ser Ser Arg Thr Glu Ile Leu His Phe Ile Asp Asn Ala Lys 
                85                  90                  95


Arg Ala His Gln Leu Pro Gly His Leu Thr Gln Glu His Asp Ala Val 
            100                 105                 110


Leu Ser Leu Ser Ala Tyr Asn Val Lys Leu Ala Trp Arg Asp Gly Glu 
        115                 120                 125


Asp Ile Ile Leu Arg Val Pro Ile His Asp Ile Ala Ala Val Ser Tyr 
    130                 135                 140


Val Arg Asp Asp Ala Ala His Leu Val Val Leu Lys Thr Ala Gln Asp 
145                 150                 155                 160


Pro Gly Ile Ser Pro Ser Gln Ser Leu Cys Ala Glu Ser Ser Arg Gly 
                165                 170                 175


Leu Ser Ala Gly Ser Leu Ser Glu Ser Ala Val Gly Pro Val Glu Ala 
            180                 185                 190


Cys Cys Leu Val Ile Leu Ala Ala Glu Ser Lys Val Ala Ala Glu Glu 
        195                 200                 205


Leu Cys Cys Leu Leu Gly Gln Val Phe Gln Val Val Tyr Thr Glu Ser 
    210                 215                 220


Thr Ile Asp Phe Leu Asp Arg Ala Ile Phe Asp Gly Ala Ser Thr Pro 
225                 230                 235                 240


Thr His His Leu Ser Leu His Ser Asp Asp Ser Ser Thr Lys Val Asp 
                245                 250                 255


Ile Lys Glu Thr Tyr Glu Val Glu Ala Ser Thr Phe Cys Phe Pro Glu 
            260                 265                 270


Ser Val Asp Val Gly Gly Ala Ser Pro His Ser Lys Thr Ile Ser Glu 
        275                 280                 285


Ser Glu Leu Ser Ala Ser Ala Thr Glu Leu Leu Gln Asp Tyr Met Leu 
    290                 295                 300


Thr Leu Arg Thr Lys Leu Ser Ser Gln Glu Ile Gln Gln Phe Ala Ala 
305                 310                 315                 320


Leu Leu His Glu Tyr Arg Asn Gly Ala Ser Ile His Glu Phe Cys Ile 
                325                 330                 335


Asn Leu Arg Gln Leu Tyr Gly Asp Ser Arg Lys Phe Leu Leu Leu Gly 
            340                 345                 350


Leu Arg Pro Phe Ile Pro Glu Lys Asp Ser Gln His Phe Glu Asn Phe 
        355                 360                 365


Leu Glu Thr Ile Gly Val Lys Asp Gly Arg Gly Ile Ile Thr Asp Ser 
    370                 375                 380


Phe Gly Arg His Arg Arg Ala Leu Ser Thr Thr Ser Ser Ser Thr Thr 
385                 390                 395                 400


Asn Gly Asn Arg Ala Thr Gly Ser Ser Asp Asp Arg Ser Ala Pro Ser 
                405                 410                 415


Glu Gly Asp Glu Trp Asp Arg Met Ile Ser Asp Ile Ser Ser Asp Ile 
            420                 425                 430


Glu Ala Leu Gly Cys Ser Met Asp Gln Asp Ser Ala 
        435                 440


<210>  428
<211>  681
<212>  DNA
<213>  Homo sapiens

<400>  428
atgcttgccc ctccagggtc catcccaggt gtggcccccg tgctgcagtc gctggtcttt     60

gctagcagaa agagtagagg acatggagca gatgaaggga caccagaggg taatgagggg    120

acaccagaga gtaatgaagg gacatcagag ggtggtgaca ggacaccaga gggcagtgag    180

gggacaccag ggagtaatgg gacatcaggg agtgatggga catcagaagg tgatgagggg    240

acaccagagg gtggtgaggg gacaccagag agtagtgagg ggacaccaga gagtaatgag    300

gggacactag aaggtgaggg gacaccagag ggcggtgaag ggacaccaga gagtaatgag    360

gggcacgaga gggtggtgag gggacatcag agggtgatgg gacaccagag ggcgatgagg    420

ggacaccgga gagtattgag gggacaccag agggcagtga agggacgcca gagagtactg    480

aggggacacc agagggtggt gaggggacac cagagagtaa tggggacacc agaaggtgag    540

gggacgccag agggcagtga agggacaccg gagagtattg ggacaccaga gggcagtgag    600

gggacaccag agggcgatga ggggacacca gagagtaatg aggggacatc agagagtaat    660

gaggggacat caaggcggtg a                                              681


<210>  429
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  429

Met Leu Ala Pro Pro Gly Ser Ile Pro Gly Val Ala Pro Val Leu Gln 
1               5                   10                  15


Ser Leu Val Phe Ala Ser Arg Lys Ser Arg Gly His Gly Ala Asp Glu 
            20                  25                  30


Gly Thr Pro Glu Gly Asn Glu Gly Thr Pro Glu Ser Asn Glu Gly Thr 
        35                  40                  45


Ser Glu Gly Gly Asp Arg Thr Pro Glu Gly Ser Glu Gly Thr Pro Gly 
    50                  55                  60


Ser Asn Gly Thr Ser Gly Ser Asp Gly Thr Ser Glu Gly Asp Glu Gly 
65                  70                  75                  80


Thr Pro Glu Gly Gly Glu Gly Thr Pro Glu Ser Ser Glu Gly Thr Pro 
                85                  90                  95


Glu Ser Asn Glu Gly Thr Leu Glu Gly Glu Gly Thr Pro Glu Gly Gly 
            100                 105                 110


Glu Gly Thr Pro Glu Ser Asn Glu Gly His Glu Arg Val Val Arg Gly 
        115                 120                 125


His Gln Arg Val Met Gly His Gln Arg Ala Met Arg Gly His Arg Arg 
    130                 135                 140


Val Leu Arg Gly His Gln Arg Ala Val Lys Gly Arg Gln Arg Val Leu 
145                 150                 155                 160


Arg Gly His Gln Arg Val Val Arg Gly His Gln Arg Val Met Gly Thr 
                165                 170                 175


Pro Glu Gly Glu Gly Thr Pro Glu Gly Ser Glu Gly Thr Pro Glu Ser 
            180                 185                 190


Ile Gly Thr Pro Glu Gly Ser Glu Gly Thr Pro Glu Gly Asp Glu Gly 
        195                 200                 205


Thr Pro Glu Ser Asn Glu Gly Thr Ser Glu Ser Asn Glu Gly Thr Ser 
    210                 215                 220


Arg Arg 
225


<210>  430
<211>  5351
<212>  DNA
<213>  Homo sapiens

<400>  430
atgataggac agatcaccga gttgcctaga gacctggaga ccgacccatc cgggtcgcct     60

tccctggtgc gctctcgtcg gctccatccc tggttgccat ggagacagga ggcggttgcc    120

acggagaccg acgactgcca ggaccagcca atcactccag agctgcagct ccagctcacc    180

ttttgcatgg agtgcctggc gagcccgcgc acgctcactc gctgggacag gcgggcgggg    240

cggcctgacg tcacccactg cccccaccgc ccggccgagg ggcggtggcc gcgcaggctc    300

ggcggggcgg cggcacggac tgacggaggg tcggaaggac tgagggacgg gcgggcgcac    360

ggccaggcca tgcctgggga ggctgcccgc gccgagctgc tgctgcccga ggcggaccga    420

cccgggcccc gcacagaact gcggggaagg tggggcgcac gaagtgcccg ccgcgagcca    480

gaaagaacgt gggggcttaa gcccttggct tccgacccag ggatcgtggg gctcgcatcc    540

cgcccgctgc atcccgttgt ttgcaccgag ctgccagcct gctggggctg ggccgctctg    600

gacagaggca gcgggttctg gaggcggggt gtccggctga tacccccagt acgatcagat    660

ctgtcctgcg atgcggccgc tgccaccacc atcctgggag gggaccggcg ggagccctgt    720

gctctgaccc cagggcccag ccacctggcc ctcacgttcc tgcccagcaa gccgggtgcc    780

cggccccagc ccgagggagc cagctgggat gcagggcctg gtggggcacc ctcggcctgg    840

gcggacccag gggagggcgg cccaagcccc atgctcctcc ctgagggcct gtcttcccag    900

gctctgtcca cggaggctcc tctcccggcc accctggagc cccggattgt gatgggagag    960

gagacgtgcc aggccctcct gtcacccaga gctgcccgga cagcgctcag ggaccaggag   1020

ggtgggcacg caagcccaga cccacccccc gagctgtgtt ctcagggtga tctttctgtg   1080

ccttcccctc ccccagaccc tgattccttc ttcacgcctc cctccacccc caccaagacc   1140

acctatgccc tgcttcctgc ctgtgggccc cacggggacg ccagggactc agaggctgag   1200

ctgcgggatg agctgctgga ctcgcccccc gcctcaccct cgggctccta cattacggcc   1260

gatggggaca gctgggcctc ttcaccctcc tgttccctca gcctgctggc tccggctgaa   1320

gggctggact tcccctcagg ctggggcctg tccccgcagg ggtccatggt ggatgaacga   1380

gagctgcacc cagcagggac cccagagccc ccgtcctctg agtccagcct ctctgcagac   1440

agcagctcct cctggggcca ggagggccac ttcttcgacc tggacttcct ggccaatgac   1500

ccaatgatcc ccgcagccct cctacccttc cagggcagcc tcatctttca ggtggaggca   1560

gtggaggtga caccgctatc cccagaggaa gaagaagagg aggctgtggc ggatcccgac   1620

ccaggtgggg acctggctgg ggagggtgag gaggacagca cgtctgcctc cttcctgcag   1680

tcactgtctg acctgtccat cacggagggc atggacgagg cttttgcctt ccgggacgac   1740

acctctgcag cctcctctga ttcagactca gcctcctacg cagaggcaga tgatgagagg   1800

ctgtacagcg gggagcccca tgcccaggcc actttgctcc aggacagtgt ccagaagaca   1860

gaggaggaga gcggaggtgg ggccaagggg ctgcaggctc aggatgggac tgtgtcctgg   1920

gccgtggagg ctgctcctca gacctcagac agaggggcct atctgtccca gagacaggaa   1980

ttgatctcag aagtaacaga agagggcctt gctttaggcc aggagtccac tgccactgtg   2040

acccctcaca ctctgcaggt agccccaggc ctccaggtgg aggtggctac cagagtgacc   2100

ccacaggctg gggaggaaga aacagactcc accgctggac aagaatctgc tgccatggca   2160

atgcctcagc cctcccagga gggcatcagc gagatcttag gccaagagtc tgtcactgca   2220

gaaaaacttc caactccaca ggaagaaaca agcctcacat tgtgtccaga ctctcctcag   2280

aacttgaagg aagaaggagg gctggacctc ccctctggca gaaagcctgt agctgcagcc   2340

acgattgtcc ccaggcaggc taaagaggac ctcaccttac cccaggactc cgctatgaca   2400

ccgcctctgc ccctacaaga cacagatctc tcatcagccc caaagcctgt ggctgcagcc   2460

acgattgtgt cccagcaggc tgaagagggc ctcaccttac cccaggactc cgttatgaca   2520

ccgcctctgc ccctacaaga cacagaactc tcgtcagccc caaagcctgt ggctgcagcc   2580

acgcttgtgt cccagcaggc tgaagagggc ctcaccttac cccaggactc cgctatgaca   2640

ccgcctctgc ccctacaaga cacagatctc tcgtcagccc caaagcctgt ggctgcagcc   2700

acgcttgtgt cccagcaggc tgaagagggc ctcaccttac cccaggactc cgctatgaca   2760

ccgcctctgc ccctacaaga cacagatctc tcgtcagccc caaagcctgt ggctgcagcc   2820

acgcttgtgt cccagcaggc tgaagagggc ctcaccttac cccaggactc cgctatgaca   2880

ccgcctctgc ccctacaaga cacagatctc tcgtcagccc caaagcctgt ggctgcagcc   2940

acgattgtgt cccagcaggc tgaagagggc ctcaccttac cccaggactc cgctatgaca   3000

ccgcctctgc ccctacaaga cacagatctc tcgtcagccc caaagcctgt ggctgcagcc   3060

acgattgtgt cccagcaggc tgaagagggc ctcaccttac cccaggactc cgctatgaca   3120

ccgcctctgc ccctacaaga cacagatctc tcgtcagccc caaagcctgt ggctgcagcc   3180

acgcctgtgt cccagcaggc tgaagagggc ctcaccttac cccaggactc cgctatgaca   3240

ccgcctctgc ccctacaaga cacagatctc tcgtcagccc caaagcctgt ggctgcagcc   3300

acgcctgtgt cccagcaggc tgaagagggc ctcaccttac cccaggactc cgctatgaca   3360

gcacctctgc ctctgcaaga cacaggcccc acctcaggtc cagagcctct ggctgtggcc   3420

acccctcaaa ccttgcaggc agaagcaggc tgtgccccag ggacagagcc tgtggccacc   3480

atggctcagc aggaagtagg tgaggcctta ggccccaggc cagcacctga ggagaagaat   3540

gcagccctcc ctacagtccc ggagcctgca gccttggacc aggtccaaca ggatgaccca   3600

cagccagctg cagaagctgg gacaccttgg gccgcacagg aagatgcgga ttccactttg   3660

ggcatggagg ccctcagtct ccctgagccg gcctctggtg ctggggagga aatagcagaa   3720

gccctttcta ggcctggacg ggaagcatgt ctggaagcgc gagcgcacac aggtgatggg   3780

gctaagcctg actcacccca aaaggagacc ctggaggttg agaaccagca ggaaggaggc   3840

ctgaagccac tggcacagga acatggaccc aggtcagcac ttggaggtgc aagggaggtc   3900

cccgatgcgc ctcctgctgc ctgccctgag gtcagccagg cccggctcct gagcccagcc   3960

agggaggaaa gaggcctgag tggcaagtcc accccggagc ccacgcttcc ctcagctgtg   4020

gccacagagg ccagtctgga ctcctgccca gagtcttcag taggggctgt gtccagtctg   4080

gacagaggct gccctgacgc gcctgccccc acgtctgcac caacctccca gcagccggag   4140

cctgtactgg gtctgggcag tgttgagcaa ccccacgaag tacccagtgt ccttggcacc   4200

cccttgctgc agcccccaga aaaccttgcc aagggtcagc ccagcacgcc cgtggacagg   4260

cccctgggcc ctgacccttc tgctcctggt acccttgctg gggcagccct acccccactg   4320

gagcccccag ccccctgcct gtgccaggac ccccaggaag actctgtgga agacgaggag   4380

cccccaggct ctctgggcct cccaccgccc caggcaggag tccagcctgc cgctgctgct   4440

gtctcaggaa ccacacagcc tctggggact gggccgcgag tcagcctctc gcctcactcc   4500

ccactcctca gccccaaggt ggcctccatg gatgccaaag acctggcctt gcagatcttg   4560

ccgccttgcc aagtgcctcc tccctctggg ccccagagcc cagctggccc tcaagggctc   4620

tcagcccccg agcagcaaga ggatgaggac agcctggagg aagactcgcc tcgggccctg   4680

ggctcgggcc agcattcgga tagccacggg gagtcatcag ccgagctgga cgagcaggac   4740

atcttggctc ctcagaccgt gcagtgtcca gcccaggccc cagcaggcgg cagtgaggag   4800

accatcgcca aagccaagca gagtcgcagt gagaagaagg cccgaaaggc aatgtcaaag   4860

ctgggcttgc ggcagattca gggagtcacc aggatcacca tccagaagtc caagaacatc   4920

ctctttgtca tcgccaagcc tgatgtcttc aagagcccag cctcagacac ttatgtggtc   4980

tttggcgagg ccaagattga ggacctgtcc cagcaagtgc acaaagccgc agctgagaag   5040

tttaaggtgc cctcagagcc ctcagccttg gtccctgagt cagcacccag gccccgggtg   5100

aggctggagt gcaaggaaga ggaagaggag gaggaggaag aggtggacga ggcggggctg   5160

gaactgcgtg acattgagct ggtgatggcg caggccaatg tgtccagggc caaggccgtg   5220

cgggctctga gagacaacca cagtgacatc gtcaacgcca tcatggaact gaccatgtag   5280

ccactgaccg gaagctggag ccatcctacg ccttccctca gctctgctac tcaataaatc   5340

ggtgtccctt c                                                        5351


<210>  431
<211>  1759
<212>  PRT
<213>  Homo sapiens

<400>  431

Met Ile Gly Gln Ile Thr Glu Leu Pro Arg Asp Leu Glu Thr Asp Pro 
1               5                   10                  15


Ser Gly Ser Pro Ser Leu Val Arg Ser Arg Arg Leu His Pro Trp Leu 
            20                  25                  30


Pro Trp Arg Gln Glu Ala Val Ala Thr Glu Thr Asp Asp Cys Gln Asp 
        35                  40                  45


Gln Pro Ile Thr Pro Glu Leu Gln Leu Gln Leu Thr Phe Cys Met Glu 
    50                  55                  60


Cys Leu Ala Ser Pro Arg Thr Leu Thr Arg Trp Asp Arg Arg Ala Gly 
65                  70                  75                  80


Arg Pro Asp Val Thr His Cys Pro His Arg Pro Ala Glu Gly Arg Trp 
                85                  90                  95


Pro Arg Arg Leu Gly Gly Ala Ala Ala Arg Thr Asp Gly Gly Ser Glu 
            100                 105                 110


Gly Leu Arg Asp Gly Arg Ala His Gly Gln Ala Met Pro Gly Glu Ala 
        115                 120                 125


Ala Arg Ala Glu Leu Leu Leu Pro Glu Ala Asp Arg Pro Gly Pro Arg 
    130                 135                 140


Thr Glu Leu Arg Gly Arg Trp Gly Ala Arg Ser Ala Arg Arg Glu Pro 
145                 150                 155                 160


Glu Arg Thr Trp Gly Leu Lys Pro Leu Ala Ser Asp Pro Gly Ile Val 
                165                 170                 175


Gly Leu Ala Ser Arg Pro Leu His Pro Val Val Cys Thr Glu Leu Pro 
            180                 185                 190


Ala Cys Trp Gly Trp Ala Ala Leu Asp Arg Gly Ser Gly Phe Trp Arg 
        195                 200                 205


Arg Gly Val Arg Leu Ile Pro Pro Val Arg Ser Asp Leu Ser Cys Asp 
    210                 215                 220


Ala Ala Ala Ala Thr Thr Ile Leu Gly Gly Asp Arg Arg Glu Pro Cys 
225                 230                 235                 240


Ala Leu Thr Pro Gly Pro Ser His Leu Ala Leu Thr Phe Leu Pro Ser 
                245                 250                 255


Lys Pro Gly Ala Arg Pro Gln Pro Glu Gly Ala Ser Trp Asp Ala Gly 
            260                 265                 270


Pro Gly Gly Ala Pro Ser Ala Trp Ala Asp Pro Gly Glu Gly Gly Pro 
        275                 280                 285


Ser Pro Met Leu Leu Pro Glu Gly Leu Ser Ser Gln Ala Leu Ser Thr 
    290                 295                 300


Glu Ala Pro Leu Pro Ala Thr Leu Glu Pro Arg Ile Val Met Gly Glu 
305                 310                 315                 320


Glu Thr Cys Gln Ala Leu Leu Ser Pro Arg Ala Ala Arg Thr Ala Leu 
                325                 330                 335


Arg Asp Gln Glu Gly Gly His Ala Ser Pro Asp Pro Pro Pro Glu Leu 
            340                 345                 350


Cys Ser Gln Gly Asp Leu Ser Val Pro Ser Pro Pro Pro Asp Pro Asp 
        355                 360                 365


Ser Phe Phe Thr Pro Pro Ser Thr Pro Thr Lys Thr Thr Tyr Ala Leu 
    370                 375                 380


Leu Pro Ala Cys Gly Pro His Gly Asp Ala Arg Asp Ser Glu Ala Glu 
385                 390                 395                 400


Leu Arg Asp Glu Leu Leu Asp Ser Pro Pro Ala Ser Pro Ser Gly Ser 
                405                 410                 415


Tyr Ile Thr Ala Asp Gly Asp Ser Trp Ala Ser Ser Pro Ser Cys Ser 
            420                 425                 430


Leu Ser Leu Leu Ala Pro Ala Glu Gly Leu Asp Phe Pro Ser Gly Trp 
        435                 440                 445


Gly Leu Ser Pro Gln Gly Ser Met Val Asp Glu Arg Glu Leu His Pro 
    450                 455                 460


Ala Gly Thr Pro Glu Pro Pro Ser Ser Glu Ser Ser Leu Ser Ala Asp 
465                 470                 475                 480


Ser Ser Ser Ser Trp Gly Gln Glu Gly His Phe Phe Asp Leu Asp Phe 
                485                 490                 495


Leu Ala Asn Asp Pro Met Ile Pro Ala Ala Leu Leu Pro Phe Gln Gly 
            500                 505                 510


Ser Leu Ile Phe Gln Val Glu Ala Val Glu Val Thr Pro Leu Ser Pro 
        515                 520                 525


Glu Glu Glu Glu Glu Glu Ala Val Ala Asp Pro Asp Pro Gly Gly Asp 
    530                 535                 540


Leu Ala Gly Glu Gly Glu Glu Asp Ser Thr Ser Ala Ser Phe Leu Gln 
545                 550                 555                 560


Ser Leu Ser Asp Leu Ser Ile Thr Glu Gly Met Asp Glu Ala Phe Ala 
                565                 570                 575


Phe Arg Asp Asp Thr Ser Ala Ala Ser Ser Asp Ser Asp Ser Ala Ser 
            580                 585                 590


Tyr Ala Glu Ala Asp Asp Glu Arg Leu Tyr Ser Gly Glu Pro His Ala 
        595                 600                 605


Gln Ala Thr Leu Leu Gln Asp Ser Val Gln Lys Thr Glu Glu Glu Ser 
    610                 615                 620


Gly Gly Gly Ala Lys Gly Leu Gln Ala Gln Asp Gly Thr Val Ser Trp 
625                 630                 635                 640


Ala Val Glu Ala Ala Pro Gln Thr Ser Asp Arg Gly Ala Tyr Leu Ser 
                645                 650                 655


Gln Arg Gln Glu Leu Ile Ser Glu Val Thr Glu Glu Gly Leu Ala Leu 
            660                 665                 670


Gly Gln Glu Ser Thr Ala Thr Val Thr Pro His Thr Leu Gln Val Ala 
        675                 680                 685


Pro Gly Leu Gln Val Glu Val Ala Thr Arg Val Thr Pro Gln Ala Gly 
    690                 695                 700


Glu Glu Glu Thr Asp Ser Thr Ala Gly Gln Glu Ser Ala Ala Met Ala 
705                 710                 715                 720


Met Pro Gln Pro Ser Gln Glu Gly Ile Ser Glu Ile Leu Gly Gln Glu 
                725                 730                 735


Ser Val Thr Ala Glu Lys Leu Pro Thr Pro Gln Glu Glu Thr Ser Leu 
            740                 745                 750


Thr Leu Cys Pro Asp Ser Pro Gln Asn Leu Lys Glu Glu Gly Gly Leu 
        755                 760                 765


Asp Leu Pro Ser Gly Arg Lys Pro Val Ala Ala Ala Thr Ile Val Pro 
    770                 775                 780


Arg Gln Ala Lys Glu Asp Leu Thr Leu Pro Gln Asp Ser Ala Met Thr 
785                 790                 795                 800


Pro Pro Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro 
                805                 810                 815


Val Ala Ala Ala Thr Ile Val Ser Gln Gln Ala Glu Glu Gly Leu Thr 
            820                 825                 830


Leu Pro Gln Asp Ser Val Met Thr Pro Pro Leu Pro Leu Gln Asp Thr 
        835                 840                 845


Glu Leu Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr Leu Val Ser 
    850                 855                 860


Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr 
865                 870                 875                 880


Pro Pro Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro 
                885                 890                 895


Val Ala Ala Ala Thr Leu Val Ser Gln Gln Ala Glu Glu Gly Leu Thr 
            900                 905                 910


Leu Pro Gln Asp Ser Ala Met Thr Pro Pro Leu Pro Leu Gln Asp Thr 
        915                 920                 925


Asp Leu Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr Leu Val Ser 
    930                 935                 940


Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr 
945                 950                 955                 960


Pro Pro Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro 
                965                 970                 975


Val Ala Ala Ala Thr Ile Val Ser Gln Gln Ala Glu Glu Gly Leu Thr 
            980                 985                 990


Leu Pro Gln Asp Ser Ala Met Thr Pro Pro Leu Pro Leu Gln Asp Thr 
        995                 1000                1005


Asp Leu Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr Ile Val Ser 
    1010                1015                1020


Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr 
1025                1030                1035                1040


Pro Pro Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro 
                1045                1050                1055


Val Ala Ala Ala Thr Pro Val Ser Gln Gln Ala Glu Glu Gly Leu Thr 
            1060                1065                1070


Leu Pro Gln Asp Ser Ala Met Thr Pro Pro Leu Pro Leu Gln Asp Thr 
        1075                1080                1085


Asp Leu Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr Pro Val Ser 
    1090                1095                1100


Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr 
1105                1110                1115                1120


Ala Pro Leu Pro Leu Gln Asp Thr Gly Pro Thr Ser Gly Pro Glu Pro 
                1125                1130                1135


Leu Ala Val Ala Thr Pro Gln Thr Leu Gln Ala Glu Ala Gly Cys Ala 
            1140                1145                1150


Pro Gly Thr Glu Pro Val Ala Thr Met Ala Gln Gln Glu Val Gly Glu 
        1155                1160                1165


Ala Leu Gly Pro Arg Pro Ala Pro Glu Glu Lys Asn Ala Ala Leu Pro 
    1170                1175                1180


Thr Val Pro Glu Pro Ala Ala Leu Asp Gln Val Gln Gln Asp Asp Pro 
1185                1190                1195                1200


Gln Pro Ala Ala Glu Ala Gly Thr Pro Trp Ala Ala Gln Glu Asp Ala 
                1205                1210                1215


Asp Ser Thr Leu Gly Met Glu Ala Leu Ser Leu Pro Glu Pro Ala Ser 
            1220                1225                1230


Gly Ala Gly Glu Glu Ile Ala Glu Ala Leu Ser Arg Pro Gly Arg Glu 
        1235                1240                1245


Ala Cys Leu Glu Ala Arg Ala His Thr Gly Asp Gly Ala Lys Pro Asp 
    1250                1255                1260


Ser Pro Gln Lys Glu Thr Leu Glu Val Glu Asn Gln Gln Glu Gly Gly 
1265                1270                1275                1280


Leu Lys Pro Leu Ala Gln Glu His Gly Pro Arg Ser Ala Leu Gly Gly 
                1285                1290                1295


Ala Arg Glu Val Pro Asp Ala Pro Pro Ala Ala Cys Pro Glu Val Ser 
            1300                1305                1310


Gln Ala Arg Leu Leu Ser Pro Ala Arg Glu Glu Arg Gly Leu Ser Gly 
        1315                1320                1325


Lys Ser Thr Pro Glu Pro Thr Leu Pro Ser Ala Val Ala Thr Glu Ala 
    1330                1335                1340


Ser Leu Asp Ser Cys Pro Glu Ser Ser Val Gly Ala Val Ser Ser Leu 
1345                1350                1355                1360


Asp Arg Gly Cys Pro Asp Ala Pro Ala Pro Thr Ser Ala Pro Thr Ser 
                1365                1370                1375


Gln Gln Pro Glu Pro Val Leu Gly Leu Gly Ser Val Glu Gln Pro His 
            1380                1385                1390


Glu Val Pro Ser Val Leu Gly Thr Pro Leu Leu Gln Pro Pro Glu Asn 
        1395                1400                1405


Leu Ala Lys Gly Gln Pro Ser Thr Pro Val Asp Arg Pro Leu Gly Pro 
    1410                1415                1420


Asp Pro Ser Ala Pro Gly Thr Leu Ala Gly Ala Ala Leu Pro Pro Leu 
1425                1430                1435                1440


Glu Pro Pro Ala Pro Cys Leu Cys Gln Asp Pro Gln Glu Asp Ser Val 
                1445                1450                1455


Glu Asp Glu Glu Pro Pro Gly Ser Leu Gly Leu Pro Pro Pro Gln Ala 
            1460                1465                1470


Gly Val Gln Pro Ala Ala Ala Ala Val Ser Gly Thr Thr Gln Pro Leu 
        1475                1480                1485


Gly Thr Gly Pro Arg Val Ser Leu Ser Pro His Ser Pro Leu Leu Ser 
    1490                1495                1500


Pro Lys Val Ala Ser Met Asp Ala Lys Asp Leu Ala Leu Gln Ile Leu 
1505                1510                1515                1520


Pro Pro Cys Gln Val Pro Pro Pro Ser Gly Pro Gln Ser Pro Ala Gly 
                1525                1530                1535


Pro Gln Gly Leu Ser Ala Pro Glu Gln Gln Glu Asp Glu Asp Ser Leu 
            1540                1545                1550


Glu Glu Asp Ser Pro Arg Ala Leu Gly Ser Gly Gln His Ser Asp Ser 
        1555                1560                1565


His Gly Glu Ser Ser Ala Glu Leu Asp Glu Gln Asp Ile Leu Ala Pro 
    1570                1575                1580


Gln Thr Val Gln Cys Pro Ala Gln Ala Pro Ala Gly Gly Ser Glu Glu 
1585                1590                1595                1600


Thr Ile Ala Lys Ala Lys Gln Ser Arg Ser Glu Lys Lys Ala Arg Lys 
                1605                1610                1615


Ala Met Ser Lys Leu Gly Leu Arg Gln Ile Gln Gly Val Thr Arg Ile 
            1620                1625                1630


Thr Ile Gln Lys Ser Lys Asn Ile Leu Phe Val Ile Ala Lys Pro Asp 
        1635                1640                1645


Val Phe Lys Ser Pro Ala Ser Asp Thr Tyr Val Val Phe Gly Glu Ala 
    1650                1655                1660


Lys Ile Glu Asp Leu Ser Gln Gln Val His Lys Ala Ala Ala Glu Lys 
1665                1670                1675                1680


Phe Lys Val Pro Ser Glu Pro Ser Ala Leu Val Pro Glu Ser Ala Pro 
                1685                1690                1695


Arg Pro Arg Val Arg Leu Glu Cys Lys Glu Glu Glu Glu Glu Glu Glu 
            1700                1705                1710


Glu Glu Val Asp Glu Ala Gly Leu Glu Leu Arg Asp Ile Glu Leu Val 
        1715                1720                1725


Met Ala Gln Ala Asn Val Ser Arg Ala Lys Ala Val Arg Ala Leu Arg 
    1730                1735                1740


Asp Asn His Ser Asp Ile Val Asn Ala Ile Met Glu Leu Thr Met 
1745                1750                1755


<210>  432
<211>  2299
<212>  DNA
<213>  Homo sapiens

<400>  432
gggaagcgcg ccgcgcacct catggttccg gggacagtta gggcggcgga tggaggtcag     60

cggtggtgct cgctgcggtt tggaatcact tgctaggagt cttgtctctc tgccacccag    120

gacatcatgg cagctcacct ggtaaagcga tgcacgtgcc tcctgagaga agctgctcgt    180

caggcccctg ccatggctcc agttggccga ctgagacttg cctgggtagc ccataagact    240

ctgacttcct cagccacctc acccatttcc cacctcccag gttccttgat ggagccggtg    300

gagaaggaac gagcatctac tccctacata gagaagcagg tggaccacct catcaagaag    360

gccacaaggc cagaggagct cctggagcta cttggtggca gtcacgactt ggacagcaat    420

caagcagcaa tggtacttat ccggctctct cacttgctgt ctgagaagcc agaagataaa    480

ggcttgctca tacaggatgc ccactttcat caacttctct gtctgctcaa cagtcagatt    540

gcctcggtct ggcatggtac cctctcgaag ctgctgggaa gcctgtatgc tctgggcatc    600

cccaaggcct ccaaggagct gcagtcggtg gagcaggagg tccgctggcg catgcggaag    660

ctcaagtaca agcacctggc cttcctggca gagtcctgtg ccaccctctc acaggagcag    720

cactcgcagg agctgctggc tgagctgctc acacacctgg aaaggcgttg gacagaaatt    780

gaagattccc acacattagt gaccgtcatg atgaaggtgg gacacctctc ggagccacta    840

atgaaccgcc tggaagacaa gtgcctggag ttggtggagc actttggccc caatgagctg    900

cggaaggtgc tggtgatgct ggcagctcag agccggcggt ccgtgccctt gctgcgggcc    960

atctcctacc acctggtgca gaagcccttc tctctgacga aagatgtgct cttggacgtg   1020

gcctatgcct atggcaaact cagctttcac cagacccagg tgtcccagcg cctggccacc   1080

gacctgctat ccctcatgcc cagcctgact tctggtgagg tggcccactg tgccaagtcc   1140

ttcgccttac tcaagtggct cagcctgccc ctgtttgagg cctttgccca gcacgtcctg   1200

aacagagcgc aggacatcac cctgccccac ctgtgcagcg tacttctggc ttttgcgcgt   1260

ctgaacttcc atccagacca agaggatcag ttcttcagcc tggtacatga gaagctgggg   1320

tcagagctgc caggcctgga gccagccctg caggtggacc tggtgtgggc cctgtgtgtg   1380

ctgcagcagg cacgggaagc agagctgcaa gccgtcctcc accctgaatt tcacatccaa   1440

tttctagggg gcaagtctca gaaggatcag aacaccttcc agaagctgct ccacatcaac   1500

gccactgccc tgctggagta ccccgagtac tcgggtcccc ttctgcctgc ctcggctgtg   1560

gcccctgggc cctcagccct tgacaggaag gtgacccccc tgcaaaagga gctgcaggag   1620

acgctgaagg ggctgctggg gagcgccgac aagggcagcc tcgaggtggc cacgcagtat   1680

ggctgggtgc tggatgctga ggtgctgctg gacagtgacg gcgagtttct gcccgtaagg   1740

gactttgtgg cacctcacct tgcccagcca actgggagcc agtcaccacc tccagggtct   1800

aagaggctag cgttcttgcg gtgggagttc cccaacttca acagccgaag caaggacttg   1860

ctgggtcgct ttgttctggc ccggcgacac atagtggctg caggcttcct gatagtggac   1920

gtcccattct atgagtggct ggaactcaag tctgaatggc agaaaggcgc ctacctcaag   1980

gacaagatgc gcaaagcggt ggctgaggag ctggccaagt gacttgtgcc agcagcatgg   2040

actgcgtgcc tctccgccgg aggtctagct gtgggcggcc aagaagggtc acccttgagg   2100

acaaacctct gtgcaggacc ttggccagag tggggagggt ggccagccac tctgagggac   2160

agaacgtcct cttgtgtata ataaaccttt aattttggtg ttggacccct ggggccttcc   2220

caggcttggt caccctctgc actgtcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2280

aaaaaaaaaa aaaaaaaaa                                                2299


<210>  433
<211>  631
<212>  PRT
<213>  Homo sapiens

<400>  433

Met Ala Ala His Leu Val Lys Arg Cys Thr Cys Leu Leu Arg Glu Ala 
1               5                   10                  15


Ala Arg Gln Ala Pro Ala Met Ala Pro Val Gly Arg Leu Arg Leu Ala 
            20                  25                  30


Trp Val Ala His Lys Thr Leu Thr Ser Ser Ala Thr Ser Pro Ile Ser 
        35                  40                  45


His Leu Pro Gly Ser Leu Met Glu Pro Val Glu Lys Glu Arg Ala Ser 
    50                  55                  60


Thr Pro Tyr Ile Glu Lys Gln Val Asp His Leu Ile Lys Lys Ala Thr 
65                  70                  75                  80


Arg Pro Glu Glu Leu Leu Glu Leu Leu Gly Gly Ser His Asp Leu Asp 
                85                  90                  95


Ser Asn Gln Ala Ala Met Val Leu Ile Arg Leu Ser His Leu Leu Ser 
            100                 105                 110


Glu Lys Pro Glu Asp Lys Gly Leu Leu Ile Gln Asp Ala His Phe His 
        115                 120                 125


Gln Leu Leu Cys Leu Leu Asn Ser Gln Ile Ala Ser Val Trp His Gly 
    130                 135                 140


Thr Leu Ser Lys Leu Leu Gly Ser Leu Tyr Ala Leu Gly Ile Pro Lys 
145                 150                 155                 160


Ala Ser Lys Glu Leu Gln Ser Val Glu Gln Glu Val Arg Trp Arg Met 
                165                 170                 175


Arg Lys Leu Lys Tyr Lys His Leu Ala Phe Leu Ala Glu Ser Cys Ala 
            180                 185                 190


Thr Leu Ser Gln Glu Gln His Ser Gln Glu Leu Leu Ala Glu Leu Leu 
        195                 200                 205


Thr His Leu Glu Arg Arg Trp Thr Glu Ile Glu Asp Ser His Thr Leu 
    210                 215                 220


Val Thr Val Met Met Lys Val Gly His Leu Ser Glu Pro Leu Met Asn 
225                 230                 235                 240


Arg Leu Glu Asp Lys Cys Leu Glu Leu Val Glu His Phe Gly Pro Asn 
                245                 250                 255


Glu Leu Arg Lys Val Leu Val Met Leu Ala Ala Gln Ser Arg Arg Ser 
            260                 265                 270


Val Pro Leu Leu Arg Ala Ile Ser Tyr His Leu Val Gln Lys Pro Phe 
        275                 280                 285


Ser Leu Thr Lys Asp Val Leu Leu Asp Val Ala Tyr Ala Tyr Gly Lys 
    290                 295                 300


Leu Ser Phe His Gln Thr Gln Val Ser Gln Arg Leu Ala Thr Asp Leu 
305                 310                 315                 320


Leu Ser Leu Met Pro Ser Leu Thr Ser Gly Glu Val Ala His Cys Ala 
                325                 330                 335


Lys Ser Phe Ala Leu Leu Lys Trp Leu Ser Leu Pro Leu Phe Glu Ala 
            340                 345                 350


Phe Ala Gln His Val Leu Asn Arg Ala Gln Asp Ile Thr Leu Pro His 
        355                 360                 365


Leu Cys Ser Val Leu Leu Ala Phe Ala Arg Leu Asn Phe His Pro Asp 
    370                 375                 380


Gln Glu Asp Gln Phe Phe Ser Leu Val His Glu Lys Leu Gly Ser Glu 
385                 390                 395                 400


Leu Pro Gly Leu Glu Pro Ala Leu Gln Val Asp Leu Val Trp Ala Leu 
                405                 410                 415


Cys Val Leu Gln Gln Ala Arg Glu Ala Glu Leu Gln Ala Val Leu His 
            420                 425                 430


Pro Glu Phe His Ile Gln Phe Leu Gly Gly Lys Ser Gln Lys Asp Gln 
        435                 440                 445


Asn Thr Phe Gln Lys Leu Leu His Ile Asn Ala Thr Ala Leu Leu Glu 
    450                 455                 460


Tyr Pro Glu Tyr Ser Gly Pro Leu Leu Pro Ala Ser Ala Val Ala Pro 
465                 470                 475                 480


Gly Pro Ser Ala Leu Asp Arg Lys Val Thr Pro Leu Gln Lys Glu Leu 
                485                 490                 495


Gln Glu Thr Leu Lys Gly Leu Leu Gly Ser Ala Asp Lys Gly Ser Leu 
            500                 505                 510


Glu Val Ala Thr Gln Tyr Gly Trp Val Leu Asp Ala Glu Val Leu Leu 
        515                 520                 525


Asp Ser Asp Gly Glu Phe Leu Pro Val Arg Asp Phe Val Ala Pro His 
    530                 535                 540


Leu Ala Gln Pro Thr Gly Ser Gln Ser Pro Pro Pro Gly Ser Lys Arg 
545                 550                 555                 560


Leu Ala Phe Leu Arg Trp Glu Phe Pro Asn Phe Asn Ser Arg Ser Lys 
                565                 570                 575


Asp Leu Leu Gly Arg Phe Val Leu Ala Arg Arg His Ile Val Ala Ala 
            580                 585                 590


Gly Phe Leu Ile Val Asp Val Pro Phe Tyr Glu Trp Leu Glu Leu Lys 
        595                 600                 605


Ser Glu Trp Gln Lys Gly Ala Tyr Leu Lys Asp Lys Met Arg Lys Ala 
    610                 615                 620


Val Ala Glu Glu Leu Ala Lys 
625                 630


<210>  434
<211>  1956
<212>  DNA
<213>  Homo sapiens

<400>  434
gggaagcgcg ccgcgcacct catggttccg gggacagtta gggcggcgga tggaggtcag     60

cggtggtgct cgctgcggtt tggaatcact tgctaggagt cttgtctctc tgccacccag    120

gacatcatgg cagctcacct ggtaaagcga tgcacgtgcc tcctgagaga agctgctcgt    180

caggcccctg ccatggctcc agttggccga ctgagacttg cctgggtagc ccataagact    240

ctgacttcct cagccacctc acccatttcc cacctcccag gttccttgat ggagccggtg    300

gagaaggaac gagcatctac tccctacata gagaagcagg tggaccacct catcaagaag    360

gccacaaggc cagaggagct cctggagcta cttggtggca gtcacgactt ggacagcaat    420

caagcagcaa tggtacttat ccggctctct cacttgctgt ctgagaagcc agaagataaa    480

ggcttgctca tacaggatgc ccactttcat caacttctct gtctgctcaa cagtcagatt    540

gcctcggtct ggcatggtac cctctcgaag ctgctgggaa gcctgtatgc tctgggcatc    600

cccaaggcct ccaaggagct gcagtcggtg gagcaggagg tccgctggcg catgcggaag    660

ctcaagtaca agcacctggc cttcctggca gagtcctgtg ccaccctctc acaggagcag    720

cactcgcagg agctgctggc tgagctgctc acacacctgg aaaggcgttg gacagaaatt    780

gaagattccc acacattagt gaccgtcatg atgaaggtgg gacacctctc ggagccacta    840

atgaaccgcc tggaagacaa gcacgtcctg aacagagcgc aggacatcac cctgccccac    900

ctgtgcagcg tacttctggc ttttgcgcgt ctgaacttcc atccagacca agaggatcag    960

ttcttcagcc tggtacatga gaagctgggg tcagagctgc caggcctgga gccagccctg   1020

caggtggacc tggtgtgggc cctgtgtgtg ctgcagcagg cacgggaagc agagctgcaa   1080

gccgtcctcc accctgaatt tcacatccaa tttctagggg gcaagtctca gaaggatcag   1140

aacaccttcc agaagctgct ccacatcaac gccactgccc tgctggagta ccccgagtac   1200

tcgggtcccc ttctgcctgc ctcggctgtg gcccctgggc cctcagccct tgacaggaag   1260

gtgacccccc tgcaaaagga gctgcaggag acgctgaagg ggctgctggg gagcgccgac   1320

aagggcagcc tcgaggtggc cacgcagtat ggctgggtgc tggatgctga ggtgctgctg   1380

gacagtgacg gcgagtttct gcccgtaagg gactttgtgg cacctcacct tgcccagcca   1440

actgggagcc agtcaccacc tccagggtct aagaggctag cgttcttgcg gtgggagttc   1500

cccaacttca acagccgaag caaggacttg ctgggtcgct ttgttctggc ccggcgacac   1560

atagtggctg caggcttcct gatagtggac gtcccattct atgagtggct ggaactcaag   1620

tctgaatggc agaaaggcgc ctacctcaag gacaagatgc gcaaagcggt ggctgaggag   1680

ctggccaagt gacttgtgcc agcagcatgg actgcgtgcc tctccgccgg aggtctagct   1740

gtgggcggcc aagaagggtc acccttgagg acaaacctct gtgcaggacc ttggccagag   1800

tggggagggt ggccagccac tctgagggac agaacgtcct cttgtgtata ataaaccttt   1860

aattttggtg ttggacccct ggggccttcc caggcttggt caccctctgc actgtcaaaa   1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                             1956


<210>  435
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  435

Met Ala Ala His Leu Val Lys Arg Cys Thr Cys Leu Leu Arg Glu Ala 
1               5                   10                  15


Ala Arg Gln Ala Pro Ala Met Ala Pro Val Gly Arg Leu Arg Leu Ala 
            20                  25                  30


Trp Val Ala His Lys Thr Leu Thr Ser Ser Ala Thr Ser Pro Ile Ser 
        35                  40                  45


His Leu Pro Gly Ser Leu Met Glu Pro Val Glu Lys Glu Arg Ala Ser 
    50                  55                  60


Thr Pro Tyr Ile Glu Lys Gln Val Asp His Leu Ile Lys Lys Ala Thr 
65                  70                  75                  80


Arg Pro Glu Glu Leu Leu Glu Leu Leu Gly Gly Ser His Asp Leu Asp 
                85                  90                  95


Ser Asn Gln Ala Ala Met Val Leu Ile Arg Leu Ser His Leu Leu Ser 
            100                 105                 110


Glu Lys Pro Glu Asp Lys Gly Leu Leu Ile Gln Asp Ala His Phe His 
        115                 120                 125


Gln Leu Leu Cys Leu Leu Asn Ser Gln Ile Ala Ser Val Trp His Gly 
    130                 135                 140


Thr Leu Ser Lys Leu Leu Gly Ser Leu Tyr Ala Leu Gly Ile Pro Lys 
145                 150                 155                 160


Ala Ser Lys Glu Leu Gln Ser Val Glu Gln Glu Val Arg Trp Arg Met 
                165                 170                 175


Arg Lys Leu Lys Tyr Lys His Leu Ala Phe Leu Ala Glu Ser Cys Ala 
            180                 185                 190


Thr Leu Ser Gln Glu Gln His Ser Gln Glu Leu Leu Ala Glu Leu Leu 
        195                 200                 205


Thr His Leu Glu Arg Arg Trp Thr Glu Ile Glu Asp Ser His Thr Leu 
    210                 215                 220


Val Thr Val Met Met Lys Val Gly His Leu Ser Glu Pro Leu Met Asn 
225                 230                 235                 240


Arg Leu Glu Asp Lys His Val Leu Asn Arg Ala Gln Asp Ile Thr Leu 
                245                 250                 255


Pro His Leu Cys Ser Val Leu Leu Ala Phe Ala Arg Leu Asn Phe His 
            260                 265                 270


Pro Asp Gln Glu Asp Gln Phe Phe Ser Leu Val His Glu Lys Leu Gly 
        275                 280                 285


Ser Glu Leu Pro Gly Leu Glu Pro Ala Leu Gln Val Asp Leu Val Trp 
    290                 295                 300


Ala Leu Cys Val Leu Gln Gln Ala Arg Glu Ala Glu Leu Gln Ala Val 
305                 310                 315                 320


Leu His Pro Glu Phe His Ile Gln Phe Leu Gly Gly Lys Ser Gln Lys 
                325                 330                 335


Asp Gln Asn Thr Phe Gln Lys Leu Leu His Ile Asn Ala Thr Ala Leu 
            340                 345                 350


Leu Glu Tyr Pro Glu Tyr Ser Gly Pro Leu Leu Pro Ala Ser Ala Val 
        355                 360                 365


Ala Pro Gly Pro Ser Ala Leu Asp Arg Lys Val Thr Pro Leu Gln Lys 
    370                 375                 380


Glu Leu Gln Glu Thr Leu Lys Gly Leu Leu Gly Ser Ala Asp Lys Gly 
385                 390                 395                 400


Ser Leu Glu Val Ala Thr Gln Tyr Gly Trp Val Leu Asp Ala Glu Val 
                405                 410                 415


Leu Leu Asp Ser Asp Gly Glu Phe Leu Pro Val Arg Asp Phe Val Ala 
            420                 425                 430


Pro His Leu Ala Gln Pro Thr Gly Ser Gln Ser Pro Pro Pro Gly Ser 
        435                 440                 445


Lys Arg Leu Ala Phe Leu Arg Trp Glu Phe Pro Asn Phe Asn Ser Arg 
    450                 455                 460


Ser Lys Asp Leu Leu Gly Arg Phe Val Leu Ala Arg Arg His Ile Val 
465                 470                 475                 480


Ala Ala Gly Phe Leu Ile Val Asp Val Pro Phe Tyr Glu Trp Leu Glu 
                485                 490                 495


Leu Lys Ser Glu Trp Gln Lys Gly Ala Tyr Leu Lys Asp Lys Met Arg 
            500                 505                 510


Lys Ala Val Ala Glu Glu Leu Ala Lys 
        515                 520


<210>  436
<211>  1935
<212>  DNA
<213>  Homo sapiens

<400>  436
gggaagcgcg ccgcgcacct catggttccg gggacagtta gggcggcgga tggagggttt     60

ggaatcactt gctaggagtc ttgtctctct gccacccagg acatcatggc agctcacctg    120

gtaaagcgat gcacgtgcct cctgagagaa gctgctcgtc aggcccctgc catggctcca    180

gttggccgac tgagacttgc ctgggtagcc cataagactc tgacttcctc agccacctca    240

cccatttccc acctcccagg ttccttgatg gagccggtgg agaaggaacg agcatctact    300

ccctacatag agaagcaggt ggaccacctc atcaagaagg ccacaaggcc agaggagctc    360

ctggagctac ttggtggcag tcacgacttg gacagcaatc aagcagcaat ggtacttatc    420

cggctctctc acttgctgtc tgagaagcca gaagataaag gcttgctcat acaggatgcc    480

cactttcatc aacttctctg tctgctcaac agtcagattg cctcggtctg gcatggtacc    540

ctctcgaagc tgctgggaag cctgtatgct ctgggcatcc ccaaggcctc caaggagctg    600

cagtcggtgg agcaggaggt ccgctggcgc atgcggaagc tcaagtacaa gcacctggcc    660

ttcctggcag agtcctgtgc caccctctca caggagcagc actcgcagga gctgctggct    720

gagctgctca cacacctgga aaggcgttgg acagaaattg aagattccca cacattagtg    780

accgtcatga tgaaggtggg acacctctcg gagccactaa tgaaccgcct ggaagacaag    840

cacgtcctga acagagcgca ggacatcacc ctgccccacc tgtgcagcgt acttctggct    900

tttgcgcgtc tgaacttcca tccagaccaa gaggatcagt tcttcagcct ggtacatgag    960

aagctggggt cagagctgcc aggcctggag ccagccctgc aggtggacct ggtgtgggcc   1020

ctgtgtgtgc tgcagcaggc acgggaagca gagctgcaag ccgtcctcca ccctgaattt   1080

cacatccaat ttctaggggg caagtctcag aaggatcaga acaccttcca gaagctgctc   1140

cacatcaacg ccactgccct gctggagtac cccgagtact cgggtcccct tctgcctgcc   1200

tcggctgtgg cccctgggcc ctcagccctt gacaggaagg tgacccccct gcaaaaggag   1260

ctgcaggaga cgctgaaggg gctgctgggg agcgccgaca agggcagcct cgaggtggcc   1320

acgcagtatg gctgggtgct ggatgctgag gtgctgctgg acagtgacgg cgagtttctg   1380

cccgtaaggg actttgtggc acctcacctt gcccagccaa ctgggagcca gtcaccacct   1440

ccagggtcta agaggctagc gttcttgcgg tgggagttcc ccaacttcaa cagccgaagc   1500

aaggacttgc tgggtcgctt tgttctggcc cggcgacaca tagtggctgc aggcttcctg   1560

atagtggacg tcccattcta tgagtggctg gaactcaagt ctgaatggca gaaaggcgcc   1620

tacctcaagg acaagatgcg caaagcggtg gctgaggagc tggccaagtg acttgtgcca   1680

gcagcatgga ctgcgtgcct ctccgccgga ggtctagctg tgggcggcca agaagggtca   1740

cccttgagga caaacctctg tgcaggacct tggccagagt ggggagggtg gccagccact   1800

ctgagggaca gaacgtcctc ttgtgtataa taaaccttta attttggtgt tggacccctg   1860

gggccttccc aggcttggtc accctctgca ctgtcaaaaa aaaaaaaaaa aaaaaaaaaa   1920

aaaaaaaaaa aaaaa                                                    1935


<210>  437
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  437

Met Ala Ala His Leu Val Lys Arg Cys Thr Cys Leu Leu Arg Glu Ala 
1               5                   10                  15


Ala Arg Gln Ala Pro Ala Met Ala Pro Val Gly Arg Leu Arg Leu Ala 
            20                  25                  30


Trp Val Ala His Lys Thr Leu Thr Ser Ser Ala Thr Ser Pro Ile Ser 
        35                  40                  45


His Leu Pro Gly Ser Leu Met Glu Pro Val Glu Lys Glu Arg Ala Ser 
    50                  55                  60


Thr Pro Tyr Ile Glu Lys Gln Val Asp His Leu Ile Lys Lys Ala Thr 
65                  70                  75                  80


Arg Pro Glu Glu Leu Leu Glu Leu Leu Gly Gly Ser His Asp Leu Asp 
                85                  90                  95


Ser Asn Gln Ala Ala Met Val Leu Ile Arg Leu Ser His Leu Leu Ser 
            100                 105                 110


Glu Lys Pro Glu Asp Lys Gly Leu Leu Ile Gln Asp Ala His Phe His 
        115                 120                 125


Gln Leu Leu Cys Leu Leu Asn Ser Gln Ile Ala Ser Val Trp His Gly 
    130                 135                 140


Thr Leu Ser Lys Leu Leu Gly Ser Leu Tyr Ala Leu Gly Ile Pro Lys 
145                 150                 155                 160


Ala Ser Lys Glu Leu Gln Ser Val Glu Gln Glu Val Arg Trp Arg Met 
                165                 170                 175


Arg Lys Leu Lys Tyr Lys His Leu Ala Phe Leu Ala Glu Ser Cys Ala 
            180                 185                 190


Thr Leu Ser Gln Glu Gln His Ser Gln Glu Leu Leu Ala Glu Leu Leu 
        195                 200                 205


Thr His Leu Glu Arg Arg Trp Thr Glu Ile Glu Asp Ser His Thr Leu 
    210                 215                 220


Val Thr Val Met Met Lys Val Gly His Leu Ser Glu Pro Leu Met Asn 
225                 230                 235                 240


Arg Leu Glu Asp Lys His Val Leu Asn Arg Ala Gln Asp Ile Thr Leu 
                245                 250                 255


Pro His Leu Cys Ser Val Leu Leu Ala Phe Ala Arg Leu Asn Phe His 
            260                 265                 270


Pro Asp Gln Glu Asp Gln Phe Phe Ser Leu Val His Glu Lys Leu Gly 
        275                 280                 285


Ser Glu Leu Pro Gly Leu Glu Pro Ala Leu Gln Val Asp Leu Val Trp 
    290                 295                 300


Ala Leu Cys Val Leu Gln Gln Ala Arg Glu Ala Glu Leu Gln Ala Val 
305                 310                 315                 320


Leu His Pro Glu Phe His Ile Gln Phe Leu Gly Gly Lys Ser Gln Lys 
                325                 330                 335


Asp Gln Asn Thr Phe Gln Lys Leu Leu His Ile Asn Ala Thr Ala Leu 
            340                 345                 350


Leu Glu Tyr Pro Glu Tyr Ser Gly Pro Leu Leu Pro Ala Ser Ala Val 
        355                 360                 365


Ala Pro Gly Pro Ser Ala Leu Asp Arg Lys Val Thr Pro Leu Gln Lys 
    370                 375                 380


Glu Leu Gln Glu Thr Leu Lys Gly Leu Leu Gly Ser Ala Asp Lys Gly 
385                 390                 395                 400


Ser Leu Glu Val Ala Thr Gln Tyr Gly Trp Val Leu Asp Ala Glu Val 
                405                 410                 415


Leu Leu Asp Ser Asp Gly Glu Phe Leu Pro Val Arg Asp Phe Val Ala 
            420                 425                 430


Pro His Leu Ala Gln Pro Thr Gly Ser Gln Ser Pro Pro Pro Gly Ser 
        435                 440                 445


Lys Arg Leu Ala Phe Leu Arg Trp Glu Phe Pro Asn Phe Asn Ser Arg 
    450                 455                 460


Ser Lys Asp Leu Leu Gly Arg Phe Val Leu Ala Arg Arg His Ile Val 
465                 470                 475                 480


Ala Ala Gly Phe Leu Ile Val Asp Val Pro Phe Tyr Glu Trp Leu Glu 
                485                 490                 495


Leu Lys Ser Glu Trp Gln Lys Gly Ala Tyr Leu Lys Asp Lys Met Arg 
            500                 505                 510


Lys Ala Val Ala Glu Glu Leu Ala Lys 
        515                 520


<210>  438
<211>  134
<212>  DNA
<213>  Homo sapiens

<400>  438
tgcagccgtg tcaaattcag tacctgtcct atgcatggta ggcactggcc cagaaggctg     60

ccacagaaac actgtgactc atgggccctg ttcctgtgtc ccaggctcag ggataaattt    120

ggttacagac atca                                                      134


<210>  439
<211>  137
<212>  DNA
<213>  Homo sapiens

<400>  439
tgcagtcaag tcaaattcag tgcccgtttc tgtcatagcg ggggctggcc cagatggctg     60

ccacagcaag ctccacagct catgggccct gggtcaccta ccctgggacc tggggataag    120

tttggctgtg gacagtg                                                   137


<210>  440
<211>  132
<212>  DNA
<213>  Homo sapiens

<400>  440
ggcagccatg tcaaattcag tgcctgccct gtctatggta ggcactggcc cagaagactg     60

ccacagaaac agtgactcac aggccctgtt actgtgtccc aggctcaggg ataaatttgg    120

ttacagacac ca                                                        132


<210>  441
<211>  3480
<212>  DNA
<213>  Homo sapiens

<400>  441
ctccctcttt ccctcacagc cgacgaggca acaattaggc tttggggata aaacgaggtg     60

cggagagcgg gctggggcat ttctccccga gatggcgggt ctgacggcgg cggccccgcg    120

gcccggagtc ctcctgctcc tgctgtccat cctccacccc tctcggcctg gaggggtccc    180

tggggccatt cctggtggag ttcctggagg agtcttttat ccaggggctg gtctcggagc    240

ccttggagga ggagcgctgg ggcctggagg caaacctctt aagccagttc ccggagggct    300

tgcgggtgct ggccttgggg cagggctcgg cgccttcccc gcagttacct ttccgggggc    360

tctggtgcct ggtggagtgg ctgacgctgc tgcagcctat aaagctgcta aggctggcgc    420

tgggcttggt ggtgtcccag gagttggtgg cttaggagtg tctgcaggtg cggtggttcc    480

tcagcctgga gccggagtga agcctgggaa agtgccgggt gtggggctgc caggtgtata    540

cccaggtggc gtgctcccag gagctcggtt ccccggtgtg ggggtgctcc ctggagttcc    600

cactggagca ggagttaagc ccaaggctcc aggtgtaggt ggagcttttg ctggaatccc    660

aggagttgga ccctttgggg gaccgcaacc tggagtccca ctggggtatc ccatcaaggc    720

ccccaagctg cctggtggct atggactgcc ctacaccaca gggaaactgc cctatggcta    780

tgggcccgga ggagtggctg gtgcagcggg caaggctggt tacccaacag ggacaggggt    840

tggcccccag gcagcagcag cagcggcagc taaagcagca gcaaagttcg gtgctggagc    900

agccggagtc ctccctggtg ttggaggggc tggtgttcct ggcgtgcctg gggcaattcc    960

tggaattgga ggcatcgcag gcgttgggac tccagctgca gctgcagctg cagcagcagc   1020

cgctaaggca gccaagtatg gagctgctgc aggcttagtg cctggtgggc caggctttgg   1080

cccgggagta gttggtgtcc caggagctgg cgttccaggt gttggtgtcc caggagctgg   1140

gattccagtt gtcccaggtg ctgggatccc aggtgctgcg gttccagggg ttgtgtcacc   1200

agaagcagct gctaaggcag ctgcaaaggc agccaaatac ggggccaggc ccggagtcgg   1260

agttggaggc attcctactt acggggttgg agctgggggc tttcccggct ttggtgtcgg   1320

agtcggaggt atccctggag tcgcaggtgt ccctggtgtc ggaggtgttc ccggagtcgg   1380

aggtgtcccg ggagttggca tttcccccga agctcaggca gcagctgccg ccaaggctgc   1440

caagtacgga gtggggaccc cagcagctgc agctgctaaa gcagccgcca aagccgccca   1500

gtttgggtta gttcctggtg tcggcgtggc tcctggagtt ggcgtggctc ctggtgtcgg   1560

tgtggctcct ggagttggct tggctcctgg agttggcgtg gctcctggag ttggtgtggc   1620

tcctggcgtt ggcgtggctc ccggcattgg ccctggtgga gttgcagctg cagcaaaatc   1680

cgctgccaag gtggctgcca aagcccagct ccgagctgca gctgggcttg gtgctggcat   1740

ccctggactt ggagttggtg tcggcgtccc tggacttgga gttggtgctg gtgttcctgg   1800

acttggagtt ggtgctggtg ttcctggctt cggggcagta cctggagccc tggctgccgc   1860

taaagcagcc aaatatggag cagcagtgcc tggggtcctt ggagggctcg gggctctcgg   1920

tggagtaggc atcccaggcg gtgtggtggg agccggaccc gccgccgccg ctgccgcagc   1980

caaagctgct gccaaagccg cccagtttgg cctagtggga gccgctgggc tcggaggact   2040

cggagtcgga gggcttggag ttccaggtgt tgggggcctt ggaggtatac ctccagctgc   2100

agccgctaaa gcagctaaat acggtgctgc tggccttgga ggtgtcctag ggggtgccgg   2160

gcagttccca cttggaggag tggcagcaag acctggcttc ggattgtctc ccattttccc   2220

aggtggggcc tgcctgggga aagcttgtgg ccggaagaga aaatgagctt cctaggaccc   2280

ctgactcacg acctcatcaa cgttggtgct actgcttggt ggagaatgta aaccctttgt   2340

aaccccatcc catgcccctc cgactcccca ccccaggagg gaacgggcag gccgggcggc   2400

cttgcagatc cacagggcaa ggaaacaaga ggggagcggc caagtgcccc gaccaggagg   2460

ccccctactt cagaggcaag ggccatgtgg tcctggcccc ccaccccatc ccttcccacc   2520

taggagctcc ccctccacac agcctccatc tccaggggaa cttggtgcta cacgctggtg   2580

ctcttatctt cctgggggga gggaggaggg aagggtggcc cctcggggaa ccccctacct   2640

ggggctcctc taaagatggt gcagacactt cctgggcagt cccagctccc cctgcccacc   2700

aggacccacc gttggctgcc atccagttgg tacccaagca cctgaagcct caaagctgga   2760

ttcgctctag catccctcct ctcctgggtc cacttggccg tctcctcccc accgatcgct   2820

gttccccaca tctggggcgc ttttgggttg gaaaaccacc ccacactggg aatagccacc   2880

ttgcccttgt agaatccatc cgcccatccg tccattcatc catcggtccg tccatccatg   2940

tccccagttg accgcccggc accactagct ggctgggtgc acccaccatc aacctggttg   3000

acctgtcatg gccgcctgtg ccctgcctcc acccccatcc tacactcccc cagggcgtgc   3060

ggggctgtgc agactggggt gccaggcatc tcctccccac ccggggtgtc cccacatgca   3120

gtactgtata ccccccatcc ctccctcggt ccactgaact tcagagcagt tcccattcct   3180

gccccgccca tctttttgtg tctcgctgtg atagatcaat aaatatttta ttttttgtcc   3240

tggatatttg gggattattt ttgattgttg atattctctt ttggttttat tgttgtggtt   3300

cattgaaaaa aaaagataat ttttttttct gatccgggga gctgtatccc cagtagaaaa   3360

aacattttaa tcactctaat ataactctgg atgaaacaca cctttttttt taataagaaa   3420

agagaattaa ctgcttcaga aatgactaat aaatgaaaaa cctttaaagg aaaaaaaaaa   3480


<210>  442
<211>  724
<212>  PRT
<213>  Homo sapiens

<400>  442

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val 
        115                 120                 125


Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly Val 
    130                 135                 140


Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro Gly Ala Arg Phe 
145                 150                 155                 160


Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly Ala Gly Val Lys 
                165                 170                 175


Pro Lys Ala Pro Gly Val Gly Gly Ala Phe Ala Gly Ile Pro Gly Val 
            180                 185                 190


Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile 
        195                 200                 205


Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu Pro Tyr Thr Thr Gly 
    210                 215                 220


Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala Gly 
225                 230                 235                 240


Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly Pro Gln Ala Ala Ala 
                245                 250                 255


Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe Gly Ala Gly Ala Ala Gly 
            260                 265                 270


Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro Gly Val Pro Gly Ala 
        275                 280                 285


Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly Thr Pro Ala Ala Ala 
    290                 295                 300


Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Ala 
305                 310                 315                 320


Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro Gly Val Val Gly Val 
                325                 330                 335


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Ile Pro 
            340                 345                 350


Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala Val Pro Gly Val Val 
        355                 360                 365


Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Lys Tyr Gly 
    370                 375                 380


Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro Thr Tyr Gly Val Gly 
385                 390                 395                 400


Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val Gly Gly Ile Pro Gly 
                405                 410                 415


Val Ala Gly Val Pro Gly Val Gly Gly Val Pro Gly Val Gly Gly Val 
            420                 425                 430


Pro Gly Val Gly Ile Ser Pro Glu Ala Gln Ala Ala Ala Ala Ala Lys 
        435                 440                 445


Ala Ala Lys Tyr Gly Val Gly Thr Pro Ala Ala Ala Ala Ala Lys Ala 
    450                 455                 460


Ala Ala Lys Ala Ala Gln Phe Gly Leu Val Pro Gly Val Gly Val Ala 
465                 470                 475                 480


Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly 
                485                 490                 495


Leu Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly 
            500                 505                 510


Val Gly Val Ala Pro Gly Ile Gly Pro Gly Gly Val Ala Ala Ala Ala 
        515                 520                 525


Lys Ser Ala Ala Lys Val Ala Ala Lys Ala Gln Leu Arg Ala Ala Ala 
    530                 535                 540


Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly Val Gly Val Gly Val Pro 
545                 550                 555                 560


Gly Leu Gly Val Gly Ala Gly Val Pro Gly Leu Gly Val Gly Ala Gly 
                565                 570                 575


Val Pro Gly Phe Gly Ala Val Pro Gly Ala Leu Ala Ala Ala Lys Ala 
            580                 585                 590


Ala Lys Tyr Gly Ala Ala Val Pro Gly Val Leu Gly Gly Leu Gly Ala 
        595                 600                 605


Leu Gly Gly Val Gly Ile Pro Gly Gly Val Val Gly Ala Gly Pro Ala 
    610                 615                 620


Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe Gly 
625                 630                 635                 640


Leu Val Gly Ala Ala Gly Leu Gly Gly Leu Gly Val Gly Gly Leu Gly 
                645                 650                 655


Val Pro Gly Val Gly Gly Leu Gly Gly Ile Pro Pro Ala Ala Ala Ala 
            660                 665                 670


Lys Ala Ala Lys Tyr Gly Ala Ala Gly Leu Gly Gly Val Leu Gly Gly 
        675                 680                 685


Ala Gly Gln Phe Pro Leu Gly Gly Val Ala Ala Arg Pro Gly Phe Gly 
    690                 695                 700


Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys Ala Cys Gly 
705                 710                 715                 720


Arg Lys Arg Lys 



<210>  443
<211>  3332
<212>  DNA
<213>  Homo sapiens

<400>  443
gcgccgagcc ggtttccccg ccggtgtccg agaggcgccc ccggcccggc ccggcccggc     60

ccgcgccctc cgcccccgcc tccccgggcc ggcggcggtg ggcgagctcg cgggcccggc    120

cgcccccagc cccagccccg ccgggccccg ccccccgtcg agtgcatgag gttgacgcta    180

ctttgttgca cctggaggga agaacgtatg ggagaggaag gaagcgagtt gcccgtgtgt    240

gcaagctgcg gccagaggat ctatgatggc cagtacctcc aggccctgaa cgcggactgg    300

cacgcagact gcttcaggtg ttgtgactgc agtgcctccc tgtcgcacca gtactatgag    360

aaggatgggc agctcttctg caagaaggac tactgggccc gctatggcga gtcctgccat    420

gggtgctctg agcaaatcac caagggactg gttatggtgg ctggggagct gaagtaccac    480

cccgagtgtt tcatctgcct cacgtgtggg acctttatcg gtgacgggga cacctacacg    540

ctggtggagc actccaagct gtactgcggg cactgctact accagactgt ggtgaccccc    600

gtcatcgagc agatcctgcc tgactcccct ggctcccacc tgccccacac cgtcaccctg    660

gtgtccatcc cagcctcatc tcatggcaag cgtggacttt cagtctccat tgaccccccg    720

cacggcccac cgggctgtgg caccgagcac tcacacaccg tccgcgtcca gggagtggat    780

ccgggctgca tgagcccaga tgtgaagaat tccatccacg tcggagaccg gatcttggaa    840

atcaatggca cgcccatccg aaatgtgccc ctggacgaga ttgacctgct gattcaggaa    900

accagccgcc tgctccagct gaccctcgag catgaccctc acgatacact gggccacggg    960

ctggggcctg agaccagccc cctgagctct ccggcttata ctcccagcgg ggaggcgggc   1020

agctctgccc ggcagaaacc tgtcttgagg agctgcagca tcgacaggtc tccgggcgct   1080

ggctcactgg gctccccggc ctcccagcgc aaggacctgg gtcgctctga gtccctccgc   1140

gtagtctgcc ggccacaccg catcttccgg ccgtcggacc tcatccacgg ggaggtgctg   1200

ggcaagggct gcttcggcca ggctatcaag gtgacacacc gtgagacagg tgaggtgatg   1260

gtgatgaagg agctgatccg gttcgacgag gagacccaga ggacgttcct caaggaggtg   1320

aaggtcatgc gatgcctgga acaccccaac gtgctcaagt tcatcggggt gctctacaag   1380

gacaagaggc tcaacttcat cactgagtac atcaagggcg gcacgctccg gggcatcatc   1440

aagagcatgg acagccagta cccatggagc cagagagtga gctttgccaa ggacatcgca   1500

tcagggatgg cctacctcca ctccatgaac atcatccacc gagacctcaa ctcccacaac   1560

tgcctggtcc gcgagaacaa gaatgtggtg gtggctgact tcgggctggc gcgtctcatg   1620

gtggacgaga agactcagcc tgagggcctg cggagcctca agaagccaga ccgcaagaag   1680

cgctacaccg tggtgggcaa cccctactgg atggcacctg agatgatcaa cggccgcagc   1740

tatgatgaga aggtggatgt gttctccttt gggatcgtcc tgtgcgagat catcgggcgg   1800

gtgaacgcag accctgacta cctgccccgc accatggact ttggcctcaa cgtgcgagga   1860

ttcctggacc gctactgccc cccaaactgc cccccgagct tcttccccat caccgtgcgc   1920

tgttgcgatc tggaccccga gaagaggcca tcctttgtga agctggaaca ctggctggag   1980

accctccgca tgcacctggc cggccacctg ccactgggcc cacagctgga gcagctggac   2040

agaggtttct gggagaccta ccggcgcggc gagagcggac tgcctgccca ccctgaggtc   2100

cccgactgag ccagggccac tcagctgccc ctgtccccac ctctggagaa tccaccccca   2160

ccagattcct ccgcgggagg tggccctcag ctgggacagt ggggacccag gcttctcctc   2220

agagccaggc cctgacttgc cttctcccac cccgtggacc gcttcccctg ccttctctct   2280

gccgtggccc agagccggcc cagctgcaca cacacaccat gctctcgccc tgctgtaacc   2340

tctgtcttgg cagggctgtc ccctcttgct tctccttgca tgagctggag ggcctgtgtg   2400

agttacgccc ctttccacac gccgctgccc cagcaaccct gttcacgctc cacctgtctg   2460

gtccatagct ccctggaggc tgggccagga ggcagcctcc gaaccatgcc ccatataacg   2520

cttgggtgcg tgggagggcg cacatcaggg cagaggccaa gttccaggtg tctgtgttcc   2580

caggaaccaa atggggagtc tggggcccgt tttcccccca gggggtgtct aggtagcaac   2640

aggtatcgag gactctccaa acccccaaag cagagagagg gctgatccca tggggcggag   2700

gtccccagtg gctgagcaaa cagccccttc tctcgctttg ggtctttttt ttgtttcttt   2760

cttaaagcca ctttagtgag aagcaggtac caagcctcag ggtgaagggg gtcccttgag   2820

ggagcgtgga gctgcggtgc cctggccggc gatggggagg agccggctcc ggcagtgaga   2880

ggataggcac agtggaccgg gcaggtgtcc accagcagct cagcccctgc agtcatctca   2940

gagccccttc ccgggcctct cccccaaggc tccctgcccc tcctcatgcc cctctgtcct   3000

ctgcgttttt tctgtgtaat ctatttttta agaagagttt gtattatttt ttcatacggc   3060

tgcagcagca gctgccaggg gcttgggatt ttatttttgt ggcgggcggg ggtgggaggg   3120

ccattttgtc actttgcctc agttgagcat ctaggaagta ttaaaactgt gaagctttct   3180

cagtgcactt tgaacctgga aaacaatccc aacaggcccg tgggaccatg acttagggag   3240

gtgggaccca cccaccccca tccaggaacc gtgacgtcca aggaaccaaa cccagacgca   3300

gaacaataaa ataaattccg tactccccac cc                                 3332


<210>  444
<211>  647
<212>  PRT
<213>  Homo sapiens

<400>  444

Met Arg Leu Thr Leu Leu Cys Cys Thr Trp Arg Glu Glu Arg Met Gly 
1               5                   10                  15


Glu Glu Gly Ser Glu Leu Pro Val Cys Ala Ser Cys Gly Gln Arg Ile 
            20                  25                  30


Tyr Asp Gly Gln Tyr Leu Gln Ala Leu Asn Ala Asp Trp His Ala Asp 
        35                  40                  45


Cys Phe Arg Cys Cys Asp Cys Ser Ala Ser Leu Ser His Gln Tyr Tyr 
    50                  55                  60


Glu Lys Asp Gly Gln Leu Phe Cys Lys Lys Asp Tyr Trp Ala Arg Tyr 
65                  70                  75                  80


Gly Glu Ser Cys His Gly Cys Ser Glu Gln Ile Thr Lys Gly Leu Val 
                85                  90                  95


Met Val Ala Gly Glu Leu Lys Tyr His Pro Glu Cys Phe Ile Cys Leu 
            100                 105                 110


Thr Cys Gly Thr Phe Ile Gly Asp Gly Asp Thr Tyr Thr Leu Val Glu 
        115                 120                 125


His Ser Lys Leu Tyr Cys Gly His Cys Tyr Tyr Gln Thr Val Val Thr 
    130                 135                 140


Pro Val Ile Glu Gln Ile Leu Pro Asp Ser Pro Gly Ser His Leu Pro 
145                 150                 155                 160


His Thr Val Thr Leu Val Ser Ile Pro Ala Ser Ser His Gly Lys Arg 
                165                 170                 175


Gly Leu Ser Val Ser Ile Asp Pro Pro His Gly Pro Pro Gly Cys Gly 
            180                 185                 190


Thr Glu His Ser His Thr Val Arg Val Gln Gly Val Asp Pro Gly Cys 
        195                 200                 205


Met Ser Pro Asp Val Lys Asn Ser Ile His Val Gly Asp Arg Ile Leu 
    210                 215                 220


Glu Ile Asn Gly Thr Pro Ile Arg Asn Val Pro Leu Asp Glu Ile Asp 
225                 230                 235                 240


Leu Leu Ile Gln Glu Thr Ser Arg Leu Leu Gln Leu Thr Leu Glu His 
                245                 250                 255


Asp Pro His Asp Thr Leu Gly His Gly Leu Gly Pro Glu Thr Ser Pro 
            260                 265                 270


Leu Ser Ser Pro Ala Tyr Thr Pro Ser Gly Glu Ala Gly Ser Ser Ala 
        275                 280                 285


Arg Gln Lys Pro Val Leu Arg Ser Cys Ser Ile Asp Arg Ser Pro Gly 
    290                 295                 300


Ala Gly Ser Leu Gly Ser Pro Ala Ser Gln Arg Lys Asp Leu Gly Arg 
305                 310                 315                 320


Ser Glu Ser Leu Arg Val Val Cys Arg Pro His Arg Ile Phe Arg Pro 
                325                 330                 335


Ser Asp Leu Ile His Gly Glu Val Leu Gly Lys Gly Cys Phe Gly Gln 
            340                 345                 350


Ala Ile Lys Val Thr His Arg Glu Thr Gly Glu Val Met Val Met Lys 
        355                 360                 365


Glu Leu Ile Arg Phe Asp Glu Glu Thr Gln Arg Thr Phe Leu Lys Glu 
    370                 375                 380


Val Lys Val Met Arg Cys Leu Glu His Pro Asn Val Leu Lys Phe Ile 
385                 390                 395                 400


Gly Val Leu Tyr Lys Asp Lys Arg Leu Asn Phe Ile Thr Glu Tyr Ile 
                405                 410                 415


Lys Gly Gly Thr Leu Arg Gly Ile Ile Lys Ser Met Asp Ser Gln Tyr 
            420                 425                 430


Pro Trp Ser Gln Arg Val Ser Phe Ala Lys Asp Ile Ala Ser Gly Met 
        435                 440                 445


Ala Tyr Leu His Ser Met Asn Ile Ile His Arg Asp Leu Asn Ser His 
    450                 455                 460


Asn Cys Leu Val Arg Glu Asn Lys Asn Val Val Val Ala Asp Phe Gly 
465                 470                 475                 480


Leu Ala Arg Leu Met Val Asp Glu Lys Thr Gln Pro Glu Gly Leu Arg 
                485                 490                 495


Ser Leu Lys Lys Pro Asp Arg Lys Lys Arg Tyr Thr Val Val Gly Asn 
            500                 505                 510


Pro Tyr Trp Met Ala Pro Glu Met Ile Asn Gly Arg Ser Tyr Asp Glu 
        515                 520                 525


Lys Val Asp Val Phe Ser Phe Gly Ile Val Leu Cys Glu Ile Ile Gly 
    530                 535                 540


Arg Val Asn Ala Asp Pro Asp Tyr Leu Pro Arg Thr Met Asp Phe Gly 
545                 550                 555                 560


Leu Asn Val Arg Gly Phe Leu Asp Arg Tyr Cys Pro Pro Asn Cys Pro 
                565                 570                 575


Pro Ser Phe Phe Pro Ile Thr Val Arg Cys Cys Asp Leu Asp Pro Glu 
            580                 585                 590


Lys Arg Pro Ser Phe Val Lys Leu Glu His Trp Leu Glu Thr Leu Arg 
        595                 600                 605


Met His Leu Ala Gly His Leu Pro Leu Gly Pro Gln Leu Glu Gln Leu 
    610                 615                 620


Asp Arg Gly Phe Trp Glu Thr Tyr Arg Arg Gly Glu Ser Gly Leu Pro 
625                 630                 635                 640


Ala His Pro Glu Val Pro Asp 
                645


<210>  445
<211>  2546
<212>  DNA
<213>  Homo sapiens

<400>  445
gacggcaaat ggcggacttc gacacctacg acgatcgggc ctacagcagc ttcggcggcg     60

gcagagggtc ccgcggcagt gctggtggcc atggttcccg tagccagaag gagttgccca    120

cagagccccc ctacacagca tacgtaggaa atctaccttt caatacggtt cagggcgaca    180

tagatgctat ctttaaggat ctcagcataa ggagtgtacg gctagtcaga gacaaagaca    240

cagataaatt taaaggattc tgctatgtag aattcgatga agtggattcc cttaaggaag    300

ccttgacata cgatggtgca ctgttgggcg atcggtcact tcgtgtggac attgcagaag    360

gcagaaaaca agataaaggt ggctttggat tcagaaaagg tggaccagat gacagaggaa    420

tgggtagctc tcgagaatct agaggtggat gggattcccg ggatgacttc aattctggct    480

tcagggatga cttcttaggg ggcaggggag gtagtcgccc aggcgaccgg cgaacaggcc    540

cccccatggg cagccgcttc agagatggcc ctcccctccg tggatccaac atggatttca    600

gagaacccac agaagaggaa agagcacaga gaccacgact ccagcttaaa cctcgaacag    660

tcgcgacgcc cctcaatcaa gtagccaatc ccaactctgc tatcttcggg ggtgccaggc    720

ctagagagga agtcgttcaa aaggagcaag aatgagcctg cggttgggag ggaatggggc    780

gtggggggtt agagcaggac cacagcctgg tgagtccccg ggcagccgtc ctgcagccgc    840

cactcctgcg cctgccattg gcctcctcac agcggaaaca cagcttgtga gtgcatgtca    900

gctgttaaca agtggttttt agtacattct gggctttgct gtatctatct agtgcctgtt    960

tgtgcgtttt tttctttctt ccgctgcttc cccattttcc ttctgtcctt tttctcctgc   1020

tccttgtttt cccagcagca catggggttc ctcggaggag cagaggtggc cgccgtgggg   1080

gggcgtttgg gctgcggtgc tgcgtcattt ttcctttgct ttctctttac tttagacact   1140

ggcccaactc caggcgtttc ctttcattcc ctcagtgctt ctcttctgac ctgcatgttg   1200

agttctgtat tgctggggct tccaacaaaa accagagtca ctgacagagg gaacagcaga   1260

gaccttgttg gtattcagct gtgatggata tagagaatca gaggcacctt gttttcacaa   1320

ctaggataaa aatatctgca gggtcctttc cattcctatt tagagggagt cctggctcca   1380

tgaccccctc ccgagtggac tgtccaagca gataggctca cacgagaaac agtgaggctg   1440

aaaggggggg ctatggaaga gcggtaggga gtccacggag aagatgcagt gaatgcttgc   1500

atgcattcac acgtgtgtgt gtcccagcta gttcactcct ttcgccgtgc gtggtggagg   1560

ctggcctctc tggctgggtg cagtgaatgg ccagcgggtt tcttttctgc tgggccaagg   1620

cgctttgggg gtggaggggg tggtgctggt gctgcactgg gctgactgcg gcgctgacgc   1680

agcgtttccc cccatccctg ttgcctgtgt gttgtgtgga tctgttccta gtataggcaa   1740

cataatgaga tactgtgctt cccacctccc cttcagttca gagccaaaat gggtctagaa   1800

tctggcactt tactcatttc ctttgataaa ttgtactatg cagagctgtc aggaaccttc   1860

agatagcagt agaggactgc agctgtctag gtctgcggcc acatcttggg gacacactgg   1920

actgttccca tgtgcagggt tcagcagtta tgtgggagtg ctaggggtta ggcttttgag   1980

cttgaacgcc tgcgtgtgaa cagatgaaaa atccttcagt acccaagtcc cagtctgtcc   2040

tatggggagc agtttggggg cggccggcag caggagcctg ggaaagaggc cctcgccagg   2100

tgatggcagg gccagggtgg cctggggcac ccagcggaat gtgcttagta tttggtcacc   2160

agccgtcatc ctgggctttt cctactgtgt cttgttacaa ggcctcagca atccacagaa   2220

ctctctctcc ttccttccac ctgtcagctt ctctgcttct gagataagaa ccatttgtgt   2280

aacaccaaca cttaacttca gaaagacatg cattatgtgg tgtaatcaaa cccgatgctt   2340

tcagatgacc tacttacatc ttcaatgtgg ataagataaa gaacaaaaca catgcatcta   2400

aactgctggg caatccagtt gacttttaaa tgtaagaatg gaattccaaa cacttaacac   2460

attcagctat atgacagaaa gtaaatctat ggatatggta ttttgtgaat gatcttttaa   2520

ataaaagaaa accttacgta atattt                                        2546


<210>  446
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  446

Met Ala Asp Phe Asp Thr Tyr Asp Asp Arg Ala Tyr Ser Ser Phe Gly 
1               5                   10                  15


Gly Gly Arg Gly Ser Arg Gly Ser Ala Gly Gly His Gly Ser Arg Ser 
            20                  25                  30


Gln Lys Glu Leu Pro Thr Glu Pro Pro Tyr Thr Ala Tyr Val Gly Asn 
        35                  40                  45


Leu Pro Phe Asn Thr Val Gln Gly Asp Ile Asp Ala Ile Phe Lys Asp 
    50                  55                  60


Leu Ser Ile Arg Ser Val Arg Leu Val Arg Asp Lys Asp Thr Asp Lys 
65                  70                  75                  80


Phe Lys Gly Phe Cys Tyr Val Glu Phe Asp Glu Val Asp Ser Leu Lys 
                85                  90                  95


Glu Ala Leu Thr Tyr Asp Gly Ala Leu Leu Gly Asp Arg Ser Leu Arg 
            100                 105                 110


Val Asp Ile Ala Glu Gly Arg Lys Gln Asp Lys Gly Gly Phe Gly Phe 
        115                 120                 125


Arg Lys Gly Gly Pro Asp Asp Arg Gly Met Gly Ser Ser Arg Glu Ser 
    130                 135                 140


Arg Gly Gly Trp Asp Ser Arg Asp Asp Phe Asn Ser Gly Phe Arg Asp 
145                 150                 155                 160


Asp Phe Leu Gly Gly Arg Gly Gly Ser Arg Pro Gly Asp Arg Arg Thr 
                165                 170                 175


Gly Pro Pro Met Gly Ser Arg Phe Arg Asp Gly Pro Pro Leu Arg Gly 
            180                 185                 190


Ser Asn Met Asp Phe Arg Glu Pro Thr Glu Glu Glu Arg Ala Gln Arg 
        195                 200                 205


Pro Arg Leu Gln Leu Lys Pro Arg Thr Val Ala Thr Pro Leu Asn Gln 
    210                 215                 220


Val Ala Asn Pro Asn Ser Ala Ile Phe Gly Gly Ala Arg Pro Arg Glu 
225                 230                 235                 240


Glu Val Val Gln Lys Glu Gln Glu 
                245


<210>  447
<211>  2486
<212>  DNA
<213>  Homo sapiens

<400>  447
gacggcaaat ggcggacttc gacacctacg acgatcgggc ctacagcagc ttcggcggcg     60

gcagagggtc ccgcggcagt gctggtggcc atggttcccg tagccagaag gagttgccca    120

cagagccccc ctacacagca tacgtaggaa atctaccttt caatacggtt cagggcgaca    180

tagatgctat ctttaaggat ctcagcataa ggagtgtacg gctagtcaga gacaaagaca    240

cagataaatt taaaggattc tgctatgtag aattcgatga agtggattcc cttaaggaag    300

ccttgacata cgatggtgca ctgttgggcg atcggtcact tcgtgtggac attgcagaag    360

gcagaaaaca agataaaggt ggctttggat tcagaaaagg tggaccagat gacagaggct    420

tcagggatga cttcttaggg ggcaggggag gtagtcgccc aggcgaccgg cgaacaggcc    480

cccccatggg cagccgcttc agagatggcc ctcccctccg tggatccaac atggatttca    540

gagaacccac agaagaggaa agagcacaga gaccacgact ccagcttaaa cctcgaacag    600

tcgcgacgcc cctcaatcaa gtagccaatc ccaactctgc tatcttcggg ggtgccaggc    660

ctagagagga agtcgttcaa aaggagcaag aatgagcctg cggttgggag ggaatggggc    720

gtggggggtt agagcaggac cacagcctgg tgagtccccg ggcagccgtc ctgcagccgc    780

cactcctgcg cctgccattg gcctcctcac agcggaaaca cagcttgtga gtgcatgtca    840

gctgttaaca agtggttttt agtacattct gggctttgct gtatctatct agtgcctgtt    900

tgtgcgtttt tttctttctt ccgctgcttc cccattttcc ttctgtcctt tttctcctgc    960

tccttgtttt cccagcagca catggggttc ctcggaggag cagaggtggc cgccgtgggg   1020

gggcgtttgg gctgcggtgc tgcgtcattt ttcctttgct ttctctttac tttagacact   1080

ggcccaactc caggcgtttc ctttcattcc ctcagtgctt ctcttctgac ctgcatgttg   1140

agttctgtat tgctggggct tccaacaaaa accagagtca ctgacagagg gaacagcaga   1200

gaccttgttg gtattcagct gtgatggata tagagaatca gaggcacctt gttttcacaa   1260

ctaggataaa aatatctgca gggtcctttc cattcctatt tagagggagt cctggctcca   1320

tgaccccctc ccgagtggac tgtccaagca gataggctca cacgagaaac agtgaggctg   1380

aaaggggggg ctatggaaga gcggtaggga gtccacggag aagatgcagt gaatgcttgc   1440

atgcattcac acgtgtgtgt gtcccagcta gttcactcct ttcgccgtgc gtggtggagg   1500

ctggcctctc tggctgggtg cagtgaatgg ccagcgggtt tcttttctgc tgggccaagg   1560

cgctttgggg gtggaggggg tggtgctggt gctgcactgg gctgactgcg gcgctgacgc   1620

agcgtttccc cccatccctg ttgcctgtgt gttgtgtgga tctgttccta gtataggcaa   1680

cataatgaga tactgtgctt cccacctccc cttcagttca gagccaaaat gggtctagaa   1740

tctggcactt tactcatttc ctttgataaa ttgtactatg cagagctgtc aggaaccttc   1800

agatagcagt agaggactgc agctgtctag gtctgcggcc acatcttggg gacacactgg   1860

actgttccca tgtgcagggt tcagcagtta tgtgggagtg ctaggggtta ggcttttgag   1920

cttgaacgcc tgcgtgtgaa cagatgaaaa atccttcagt acccaagtcc cagtctgtcc   1980

tatggggagc agtttggggg cggccggcag caggagcctg ggaaagaggc cctcgccagg   2040

tgatggcagg gccagggtgg cctggggcac ccagcggaat gtgcttagta tttggtcacc   2100

agccgtcatc ctgggctttt cctactgtgt cttgttacaa ggcctcagca atccacagaa   2160

ctctctctcc ttccttccac ctgtcagctt ctctgcttct gagataagaa ccatttgtgt   2220

aacaccaaca cttaacttca gaaagacatg cattatgtgg tgtaatcaaa cccgatgctt   2280

tcagatgacc tacttacatc ttcaatgtgg ataagataaa gaacaaaaca catgcatcta   2340

aactgctggg caatccagtt gacttttaaa tgtaagaatg gaattccaaa cacttaacac   2400

attcagctat atgacagaaa gtaaatctat ggatatggta ttttgtgaat gatcttttaa   2460

ataaaagaaa accttacgta atattt                                        2486


<210>  448
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  448

Met Ala Asp Phe Asp Thr Tyr Asp Asp Arg Ala Tyr Ser Ser Phe Gly 
1               5                   10                  15


Gly Gly Arg Gly Ser Arg Gly Ser Ala Gly Gly His Gly Ser Arg Ser 
            20                  25                  30


Gln Lys Glu Leu Pro Thr Glu Pro Pro Tyr Thr Ala Tyr Val Gly Asn 
        35                  40                  45


Leu Pro Phe Asn Thr Val Gln Gly Asp Ile Asp Ala Ile Phe Lys Asp 
    50                  55                  60


Leu Ser Ile Arg Ser Val Arg Leu Val Arg Asp Lys Asp Thr Asp Lys 
65                  70                  75                  80


Phe Lys Gly Phe Cys Tyr Val Glu Phe Asp Glu Val Asp Ser Leu Lys 
                85                  90                  95


Glu Ala Leu Thr Tyr Asp Gly Ala Leu Leu Gly Asp Arg Ser Leu Arg 
            100                 105                 110


Val Asp Ile Ala Glu Gly Arg Lys Gln Asp Lys Gly Gly Phe Gly Phe 
        115                 120                 125


Arg Lys Gly Gly Pro Asp Asp Arg Gly Phe Arg Asp Asp Phe Leu Gly 
    130                 135                 140


Gly Arg Gly Gly Ser Arg Pro Gly Asp Arg Arg Thr Gly Pro Pro Met 
145                 150                 155                 160


Gly Ser Arg Phe Arg Asp Gly Pro Pro Leu Arg Gly Ser Asn Met Asp 
                165                 170                 175


Phe Arg Glu Pro Thr Glu Glu Glu Arg Ala Gln Arg Pro Arg Leu Gln 
            180                 185                 190


Leu Lys Pro Arg Thr Val Ala Thr Pro Leu Asn Gln Val Ala Asn Pro 
        195                 200                 205


Asn Ser Ala Ile Phe Gly Gly Ala Arg Pro Arg Glu Glu Val Val Gln 
    210                 215                 220


Lys Glu Gln Glu 
225


<210>  449
<211>  2010
<212>  DNA
<213>  Homo sapiens

<400>  449
acgtgatcca cccgcctcgg cctcccaaag tttttggatt acaggtgtga gccacctcgc     60

ccggtcctat ctctctttct tctctttctc cctctcactt tgtttctctt ctctctctct    120

ctcccgcctc cttcccccgt ctcccctccc ttccccccac cgccctcttc atagctgagc    180

ctgtccggca gtgcggcgga tgtacggatg attcagtggc tggcaggaag cccgccctgc    240

ccgcccgcca gtgtcagtgg tgttggcatc agcttgggca ggtgtgcggg ctcaggatgg    300

ggcggccgtg gtgaggaacc ctggactctc agcatcacaa gaggcaacac caggagccaa    360

catgagctcg gggactgaac tgctgtggcc cggagcagcg ctgctggtgc tgttgggggt    420

ggcagccagt ctgtgtgtgc gctgctcacg cccaggtgca aagaggtcag agaaaatcta    480

ccagcagaga agtctgcgtg aggaccaaca gagctttacg gggtcccgga cctactcctt    540

ggtcgggcag gcatggccag gacccctggc ggacatggca cccacaagga aggacaagct    600

gttgcaattc taccccagcc tggaggatcc agcatcttcc aggtaccaga acttcagcaa    660

aggaagcaga cacgggtcgg aggaagccta catagacccc attgccatgg agtattacaa    720

ctgggggcgg ttctcgaagc ccccagaaga tgatgatgcc aattcctacg agaatgtgct    780

catttgcaag cagaaaacca cagagacagg tgcccagcag gagggcatag gtggcctctg    840

cagaggggac ctcagcctgt cactggccct gaagactggc cccacttctg gtctctgtcc    900

ctctgcctcc ccggaagaag atgaggaatc tgaggattat cagaactcag catccatcca    960

tcagtggcgc gagtccagga aggtcatggg gcaactccag agagaagcat cccctggccc   1020

ggtgggaagc ccagacgagg aggacgggga accggattac gtgaatgggg aggtggcagc   1080

cacagaagcc tagggcagac caagaagaaa ggagccaagg caaagaggga ccactgtgct   1140

catggaccca tcgctgcctt ccaaggacca tttcccagag ctactcaact tttaagcccc   1200

tgccatggtt gctcctggaa ggagaaccag ccaccctgag gaccacctgg ccatgcgtgc   1260

acagcctggg aaaagacagt tactcacggg agctgcaggc ccgtcaccaa gccctctccc   1320

gacccaggct ttgtggggca ggcacctggt accaagggta acccggctcc tggtatggac   1380

ggatgcgcag gatttaggat aagctgtcac ccagtcccca taacaaaacc actgtccaac   1440

actggtatct gtgttctttt gtgctatgaa tttggattcc taattgctat tgttggttgc   1500

tggggtttta aatgattgat aagcttgtac agttaactta tagaggggga gccatattta   1560

acattctgga tttcagagta gagatttctg tgttgtctcc tagaaagcat tacatgtagt   1620

ttatttcagc atccttgttg ggtggggccc tggctctctt cccctttggt gggacctccc   1680

ctttctttgg gcttcagttc actcaggaag aaatgaggct gtcgccatct ttatgtgctt   1740

ccagtggaaa tgtcacttgc tacagacaat agtgcatgag agtctagaga agtagtgacc   1800

agaacagggc agagtaggtc ccctccatgg ccctgaatcc tcctctgctc cagggctggc   1860

ctctgcagag ctgattaaac agtgttgtga ctgtctcatg ggaagagctg gggcccagag   1920

ggaccttgag tcagaaatgt tgccagaaaa agtatctcct ccaaccaaaa catctcaata   1980

aaaccatttt agttgaaaag caaaaaaaaa                                    2010


<210>  450
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  450

Met Ser Ser Gly Thr Glu Leu Leu Trp Pro Gly Ala Ala Leu Leu Val 
1               5                   10                  15


Leu Leu Gly Val Ala Ala Ser Leu Cys Val Arg Cys Ser Arg Pro Gly 
            20                  25                  30


Ala Lys Arg Ser Glu Lys Ile Tyr Gln Gln Arg Ser Leu Arg Glu Asp 
        35                  40                  45


Gln Gln Ser Phe Thr Gly Ser Arg Thr Tyr Ser Leu Val Gly Gln Ala 
    50                  55                  60


Trp Pro Gly Pro Leu Ala Asp Met Ala Pro Thr Arg Lys Asp Lys Leu 
65                  70                  75                  80


Leu Gln Phe Tyr Pro Ser Leu Glu Asp Pro Ala Ser Ser Arg Tyr Gln 
                85                  90                  95


Asn Phe Ser Lys Gly Ser Arg His Gly Ser Glu Glu Ala Tyr Ile Asp 
            100                 105                 110


Pro Ile Ala Met Glu Tyr Tyr Asn Trp Gly Arg Phe Ser Lys Pro Pro 
        115                 120                 125


Glu Asp Asp Asp Ala Asn Ser Tyr Glu Asn Val Leu Ile Cys Lys Gln 
    130                 135                 140


Lys Thr Thr Glu Thr Gly Ala Gln Gln Glu Gly Ile Gly Gly Leu Cys 
145                 150                 155                 160


Arg Gly Asp Leu Ser Leu Ser Leu Ala Leu Lys Thr Gly Pro Thr Ser 
                165                 170                 175


Gly Leu Cys Pro Ser Ala Ser Pro Glu Glu Asp Glu Glu Ser Glu Asp 
            180                 185                 190


Tyr Gln Asn Ser Ala Ser Ile His Gln Trp Arg Glu Ser Arg Lys Val 
        195                 200                 205


Met Gly Gln Leu Gln Arg Glu Ala Ser Pro Gly Pro Val Gly Ser Pro 
    210                 215                 220


Asp Glu Glu Asp Gly Glu Pro Asp Tyr Val Asn Gly Glu Val Ala Ala 
225                 230                 235                 240


Thr Glu Ala 



<210>  451
<211>  2129
<212>  DNA
<213>  Homo sapiens

<400>  451
acgtgatcca cccgcctcgg cctcccaaag tttttggatt acaggtgtga gccacctcgc     60

ccggtcctat ctctctttct tctctttctc cctctcactt tgtttctctt ctctctctct    120

ctcccgcctc cttcccccgt ctcccctccc ttccccccac cgccctcttc atagctgagc    180

ctgtccggca gtgcggcgga tgtacggatg attcagtggc tggcaggaag cccgccctgc    240

ccgcccgcca gtgtcagtgg tgttggcatc agcttgggca ggtgtgcggg ctcaggatgg    300

ggcggccgtg gtgaggaacc ctggactctc agagatggaa tttcaccgtg ttgcctaggc    360

tggtctggag ctcttgatct caagcgatcc tccctgcctc ggcctcccaa cgtgctggga    420

ttataggcgt gagccaccgc tcctggccag gcatcacaag aggcaacacc aggagccaac    480

atgagctcgg ggactgaact gctgtggccc ggagcagcgc tgctggtgct gttgggggtg    540

gcagccagtc tgtgtgtgcg ctgctcacgc ccaggtgcaa agaggtcaga gaaaatctac    600

cagcagagaa gtctgcgtga ggaccaacag agctttacgg ggtcccggac ctactccttg    660

gtcgggcagg catggccagg acccctggcg gacatggcac ccacaaggaa ggacaagctg    720

ttgcaattct accccagcct ggaggatcca gcatcttcca ggtaccagaa cttcagcaaa    780

ggaagcagac acgggtcgga ggaagcctac atagacccca ttgccatgga gtattacaac    840

tgggggcggt tctcgaagcc cccagaagat gatgatgcca attcctacga gaatgtgctc    900

atttgcaagc agaaaaccac agagacaggt gcccagcagg agggcatagg tggcctctgc    960

agaggggacc tcagcctgtc actggccctg aagactggcc ccacttctgg tctctgtccc   1020

tctgcctccc cggaagaaga tgaggaatct gaggattatc agaactcagc atccatccat   1080

cagtggcgcg agtccaggaa ggtcatgggg caactccaga gagaagcatc ccctggcccg   1140

gtgggaagcc cagacgagga ggacggggaa ccggattacg tgaatgggga ggtggcagcc   1200

acagaagcct agggcagacc aagaagaaag gagccaaggc aaagagggac cactgtgctc   1260

atggacccat cgctgccttc caaggaccat ttcccagagc tactcaactt ttaagcccct   1320

gccatggttg ctcctggaag gagaaccagc caccctgagg accacctggc catgcgtgca   1380

cagcctggga aaagacagtt actcacggga gctgcaggcc cgtcaccaag ccctctcccg   1440

acccaggctt tgtggggcag gcacctggta ccaagggtaa cccggctcct ggtatggacg   1500

gatgcgcagg atttaggata agctgtcacc cagtccccat aacaaaacca ctgtccaaca   1560

ctggtatctg tgttcttttg tgctatgaat ttggattcct aattgctatt gttggttgct   1620

ggggttttaa atgattgata agcttgtaca gttaacttat agagggggag ccatatttaa   1680

cattctggat ttcagagtag agatttctgt gttgtctcct agaaagcatt acatgtagtt   1740

tatttcagca tccttgttgg gtggggccct ggctctcttc ccctttggtg ggacctcccc   1800

tttctttggg cttcagttca ctcaggaaga aatgaggctg tcgccatctt tatgtgcttc   1860

cagtggaaat gtcacttgct acagacaata gtgcatgaga gtctagagaa gtagtgacca   1920

gaacagggca gagtaggtcc cctccatggc cctgaatcct cctctgctcc agggctggcc   1980

tctgcagagc tgattaaaca gtgttgtgac tgtctcatgg gaagagctgg ggcccagagg   2040

gaccttgagt cagaaatgtt gccagaaaaa gtatctcctc caaccaaaac atctcaataa   2100

aaccatttta gttgaaaagc aaaaaaaaa                                     2129


<210>  452
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  452

Met Ser Ser Gly Thr Glu Leu Leu Trp Pro Gly Ala Ala Leu Leu Val 
1               5                   10                  15


Leu Leu Gly Val Ala Ala Ser Leu Cys Val Arg Cys Ser Arg Pro Gly 
            20                  25                  30


Ala Lys Arg Ser Glu Lys Ile Tyr Gln Gln Arg Ser Leu Arg Glu Asp 
        35                  40                  45


Gln Gln Ser Phe Thr Gly Ser Arg Thr Tyr Ser Leu Val Gly Gln Ala 
    50                  55                  60


Trp Pro Gly Pro Leu Ala Asp Met Ala Pro Thr Arg Lys Asp Lys Leu 
65                  70                  75                  80


Leu Gln Phe Tyr Pro Ser Leu Glu Asp Pro Ala Ser Ser Arg Tyr Gln 
                85                  90                  95


Asn Phe Ser Lys Gly Ser Arg His Gly Ser Glu Glu Ala Tyr Ile Asp 
            100                 105                 110


Pro Ile Ala Met Glu Tyr Tyr Asn Trp Gly Arg Phe Ser Lys Pro Pro 
        115                 120                 125


Glu Asp Asp Asp Ala Asn Ser Tyr Glu Asn Val Leu Ile Cys Lys Gln 
    130                 135                 140


Lys Thr Thr Glu Thr Gly Ala Gln Gln Glu Gly Ile Gly Gly Leu Cys 
145                 150                 155                 160


Arg Gly Asp Leu Ser Leu Ser Leu Ala Leu Lys Thr Gly Pro Thr Ser 
                165                 170                 175


Gly Leu Cys Pro Ser Ala Ser Pro Glu Glu Asp Glu Glu Ser Glu Asp 
            180                 185                 190


Tyr Gln Asn Ser Ala Ser Ile His Gln Trp Arg Glu Ser Arg Lys Val 
        195                 200                 205


Met Gly Gln Leu Gln Arg Glu Ala Ser Pro Gly Pro Val Gly Ser Pro 
    210                 215                 220


Asp Glu Glu Asp Gly Glu Pro Asp Tyr Val Asn Gly Glu Val Ala Ala 
225                 230                 235                 240


Thr Glu Ala 



<210>  453
<211>  1613
<212>  DNA
<213>  Homo sapiens

<400>  453
ggtggcggga agaggaggcg cgagaatgga ggtggaggcc gtctgtggtg gcgcgggcga     60

ggtggaggcc caggactctg accctgcccc tgccttcagc aaggcccccg gcagcgccgg    120

ccactacgaa ctgccgtggg ttgaaaaata taggccagta aagctgaatg aaattgtcgg    180

gaatgaagac accgtgagca ggctagaggt ctttgcaagg gaaggaaatg tgcccaacat    240

catcattgcg ggccctccag gaaccggcaa gaccacaagc attctgtgct tggcccgggc    300

cctgctgggc ccagcactca aagatgccat gttggaactc aatgcttcaa atgacagcat    360

gaccgacgga gcccagcaag ccttgaggag aaccatggaa atctactcta aaaccactcg    420

cttcgccctt gcttgtaatg cttcggataa gatcatcgag cccattcagt cccgctgtgc    480

agtcctccgg tacacaaagc tgaccgacgc ccagatcctc accaggctga tgaatgttat    540

cgagaaggag agggtaccct acactgatga cggcctagaa gccatcatct tcacggccca    600

gggagacatg aggcaggcgc tgaacaacct gcagtccacc ttctcaggat ttggcttcat    660

taacagtgag aacgtgttca aggtctgtga cgagccccac ccactgctgg taaaggagat    720

gatccagcac tgtgtgaatg ccaacattga cgaagcctac aagattcttg ctcacttgtg    780

gcatctgggc tactcaccag aagatatcat tggcaacatc tttcgagtgt gtaaaacttt    840

ccaaatggca gaatacctga aactggagtt tatcaaggaa attggataca ctcacatgaa    900

aatagcggaa ggagtgaact ctcttttgca gatggcaggc ctcctggcaa ggctgtgtca    960

gaagacaatg gccccggtgg ccagttagag cagagacttc actgactgac ttacaggtgc   1020

cctattctga ggtacaggag ccgcggcttt ctgatggggg aaaatgccgc cttaggctgg   1080

agccaacatg actgtccttt aaactccagt ggctggccag gcacggtagc tcacgcctgt   1140

aatcccaaca ctttgggagg ccgaggcagg tggatcacct gaggtcagaa gttcaagacc   1200

agcctggcca acatggggaa accctgtctt tactaaaaat ataaaaatta gctgggtgtg   1260

gtggcgggca cctgtaatcc cagctactcg ggaggctgtg gcaggagaat cgcttgaacc   1320

caggaggtgg aggttgcagt gagccaagat cacaccattg cactccagcc tgggcgacag   1380

agtctccatc tggggaaaaa aattaaataa ataaactccc gtgacttgca tgtttgcttc   1440

tgggacgtct gtgccccgca agtgtttgag tttggcctcc accccattga tgcggtgacg   1500

gggcggaaag gcgcagagaa gctgagggcg gtctctgatc tgtgtgtggg ttgacatttt   1560

agctaataaa gccttgcagt gtttgttggc aaaaaaaaaa aaaaaaaaaa aaa          1613


<210>  454
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  454

Met Glu Val Glu Ala Val Cys Gly Gly Ala Gly Glu Val Glu Ala Gln 
1               5                   10                  15


Asp Ser Asp Pro Ala Pro Ala Phe Ser Lys Ala Pro Gly Ser Ala Gly 
            20                  25                  30


His Tyr Glu Leu Pro Trp Val Glu Lys Tyr Arg Pro Val Lys Leu Asn 
        35                  40                  45


Glu Ile Val Gly Asn Glu Asp Thr Val Ser Arg Leu Glu Val Phe Ala 
    50                  55                  60


Arg Glu Gly Asn Val Pro Asn Ile Ile Ile Ala Gly Pro Pro Gly Thr 
65                  70                  75                  80


Gly Lys Thr Thr Ser Ile Leu Cys Leu Ala Arg Ala Leu Leu Gly Pro 
                85                  90                  95


Ala Leu Lys Asp Ala Met Leu Glu Leu Asn Ala Ser Asn Asp Ser Met 
            100                 105                 110


Thr Asp Gly Ala Gln Gln Ala Leu Arg Arg Thr Met Glu Ile Tyr Ser 
        115                 120                 125


Lys Thr Thr Arg Phe Ala Leu Ala Cys Asn Ala Ser Asp Lys Ile Ile 
    130                 135                 140


Glu Pro Ile Gln Ser Arg Cys Ala Val Leu Arg Tyr Thr Lys Leu Thr 
145                 150                 155                 160


Asp Ala Gln Ile Leu Thr Arg Leu Met Asn Val Ile Glu Lys Glu Arg 
                165                 170                 175


Val Pro Tyr Thr Asp Asp Gly Leu Glu Ala Ile Ile Phe Thr Ala Gln 
            180                 185                 190


Gly Asp Met Arg Gln Ala Leu Asn Asn Leu Gln Ser Thr Phe Ser Gly 
        195                 200                 205


Phe Gly Phe Ile Asn Ser Glu Asn Val Phe Lys Val Cys Asp Glu Pro 
    210                 215                 220


His Pro Leu Leu Val Lys Glu Met Ile Gln His Cys Val Asn Ala Asn 
225                 230                 235                 240


Ile Asp Glu Ala Tyr Lys Ile Leu Ala His Leu Trp His Leu Gly Tyr 
                245                 250                 255


Ser Pro Glu Asp Ile Ile Gly Asn Ile Phe Arg Val Cys Lys Thr Phe 
            260                 265                 270


Gln Met Ala Glu Tyr Leu Lys Leu Glu Phe Ile Lys Glu Ile Gly Tyr 
        275                 280                 285


Thr His Met Lys Ile Ala Glu Gly Val Asn Ser Leu Leu Gln Met Ala 
    290                 295                 300


Gly Leu Leu Ala Arg Leu Cys Gln Lys Thr Met Ala Pro Val Ala Ser 
305                 310                 315                 320


<210>  455
<211>  1715
<212>  DNA
<213>  Homo sapiens

<400>  455
ggtggcggga agaggaggcg cgagaatgga ggtggaggcc gtctgtggtg gcgcgggcga     60

ggtggaggcc caggactctg accctgcccc tgccttcagc aaggcccccg gcagcgccgg    120

ccactacgaa ctgccgtggg ttgaaaaata taggccagta aagctgaatg aaattgtcgg    180

gaatgaagac accgtgagca ggctagaggt ctttgcaagg gaaggaaatg tgcccaacat    240

catcattgcg ggccctccag gaaccggcaa gaccacaagc attctgtgct tggcccgggc    300

cctgctgggc ccagcactca aagatgccat gttggaactc aatgcttcaa atgacagggg    360

cattgacgtt gtgaggaata aaattaaaat gtttgctcaa caaaaagtca ctcttcccaa    420

aggccgacat aagatcatca ttctggatga agcagacagc atgaccgacg gagcccagca    480

agccttgagg agaaccatgg aaatctactc taaaaccact cgcttcgccc ttgcttgtaa    540

tgcttcggat aagatcatcg agcccattca gtcccgctgt gcagtcctcc ggtacacaaa    600

gctgaccgac gcccagatcc tcaccaggct gatgaatgtt atcgagaagg agagggtacc    660

ctacactgat gacggcctag aagccatcat cttcacggcc cagggagaca tgaggcaggc    720

gctgaacaac ctgcagtcca ccttctcagg atttggcttc attaacagtg agaacgtgtt    780

caaggtctgt gacgagcccc acccactgct ggtaaaggag atgatccagc actgtgtgaa    840

tgccaacatt gacgaagcct acaagattct tgctcacttg tggcatctgg gctactcacc    900

agaagatatc attggcaaca tctttcgagt gtgtaaaact ttccaaatgg cagaatacct    960

gaaactggag tttatcaagg aaattggata cactcacatg aaaatagcgg aaggagtgaa   1020

ctctcttttg cagatggcag gcctcctggc aaggctgtgt cagaagacaa tggccccggt   1080

ggccagttag agcagagact tcactgactg acttacaggt gccctattct gaggtacagg   1140

agccgcggct ttctgatggg ggaaaatgcc gccttaggct ggagccaaca tgactgtcct   1200

ttaaactcca gtggctggcc aggcacggta gctcacgcct gtaatcccaa cactttggga   1260

ggccgaggca ggtggatcac ctgaggtcag aagttcaaga ccagcctggc caacatgggg   1320

aaaccctgtc tttactaaaa atataaaaat tagctgggtg tggtggcggg cacctgtaat   1380

cccagctact cgggaggctg tggcaggaga atcgcttgaa cccaggaggt ggaggttgca   1440

gtgagccaag atcacaccat tgcactccag cctgggcgac agagtctcca tctggggaaa   1500

aaaattaaat aaataaactc ccgtgacttg catgtttgct tctgggacgt ctgtgccccg   1560

caagtgtttg agtttggcct ccaccccatt gatgcggtga cggggcggaa aggcgcagag   1620

aagctgaggg cggtctctga tctgtgtgtg ggttgacatt ttagctaata aagccttgca   1680

gtgtttgttg gcaaaaaaaa aaaaaaaaaa aaaaa                              1715


<210>  456
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  456

Met Glu Val Glu Ala Val Cys Gly Gly Ala Gly Glu Val Glu Ala Gln 
1               5                   10                  15


Asp Ser Asp Pro Ala Pro Ala Phe Ser Lys Ala Pro Gly Ser Ala Gly 
            20                  25                  30


His Tyr Glu Leu Pro Trp Val Glu Lys Tyr Arg Pro Val Lys Leu Asn 
        35                  40                  45


Glu Ile Val Gly Asn Glu Asp Thr Val Ser Arg Leu Glu Val Phe Ala 
    50                  55                  60


Arg Glu Gly Asn Val Pro Asn Ile Ile Ile Ala Gly Pro Pro Gly Thr 
65                  70                  75                  80


Gly Lys Thr Thr Ser Ile Leu Cys Leu Ala Arg Ala Leu Leu Gly Pro 
                85                  90                  95


Ala Leu Lys Asp Ala Met Leu Glu Leu Asn Ala Ser Asn Asp Arg Gly 
            100                 105                 110


Ile Asp Val Val Arg Asn Lys Ile Lys Met Phe Ala Gln Gln Lys Val 
        115                 120                 125


Thr Leu Pro Lys Gly Arg His Lys Ile Ile Ile Leu Asp Glu Ala Asp 
    130                 135                 140


Ser Met Thr Asp Gly Ala Gln Gln Ala Leu Arg Arg Thr Met Glu Ile 
145                 150                 155                 160


Tyr Ser Lys Thr Thr Arg Phe Ala Leu Ala Cys Asn Ala Ser Asp Lys 
                165                 170                 175


Ile Ile Glu Pro Ile Gln Ser Arg Cys Ala Val Leu Arg Tyr Thr Lys 
            180                 185                 190


Leu Thr Asp Ala Gln Ile Leu Thr Arg Leu Met Asn Val Ile Glu Lys 
        195                 200                 205


Glu Arg Val Pro Tyr Thr Asp Asp Gly Leu Glu Ala Ile Ile Phe Thr 
    210                 215                 220


Ala Gln Gly Asp Met Arg Gln Ala Leu Asn Asn Leu Gln Ser Thr Phe 
225                 230                 235                 240


Ser Gly Phe Gly Phe Ile Asn Ser Glu Asn Val Phe Lys Val Cys Asp 
                245                 250                 255


Glu Pro His Pro Leu Leu Val Lys Glu Met Ile Gln His Cys Val Asn 
            260                 265                 270


Ala Asn Ile Asp Glu Ala Tyr Lys Ile Leu Ala His Leu Trp His Leu 
        275                 280                 285


Gly Tyr Ser Pro Glu Asp Ile Ile Gly Asn Ile Phe Arg Val Cys Lys 
    290                 295                 300


Thr Phe Gln Met Ala Glu Tyr Leu Lys Leu Glu Phe Ile Lys Glu Ile 
305                 310                 315                 320


Gly Tyr Thr His Met Lys Ile Ala Glu Gly Val Asn Ser Leu Leu Gln 
                325                 330                 335


Met Ala Gly Leu Leu Ala Arg Leu Cys Gln Lys Thr Met Ala Pro Val 
            340                 345                 350


Ala Ser 



<210>  457
<211>  5563
<212>  DNA
<213>  Homo sapiens

<400>  457
cggctcggcc gcggggcgcg caggcggctg ctgggcggcc tcggtgcgcg cctcccgcct     60

tcccagagac gtggcgcgag gcccgggccc tgagcaccta tcgcggggat ccccggcgcc    120

aggagggggt gcagccggtg ggcagcgccg cgcagggagg ggccgcagca tcctcgcccc    180

ccagcgcgcc cgggcccgag aggaggaggc cggggctctc cgggcctccc gccgcttagc    240

ctgatgctgg aaggacgaag gtgagtgaag atggcagaga ggacgtgacc agcactcacc    300

cttgtccacc tgcccagtgg caccgccatg cagaagccca gcggcctgaa gccccccggc    360

cgtgggggga agcactccag ccccatgggc cggacatcta ctgggtcagc ttcatcctcg    420

gcggcggtgg ccgctagctc caaggaaggc tccccactgc acaaacagtc atctggaccc    480

tcctcctccc cggccgcagc tgctgccccc gagaagccgg gccccaaggc ggcggaagtg    540

ggggatgact tcctggggga ctttgtggtg ggcgagcggg tgtgggtgaa cggcgtgaag    600

ccaggcgtgg tgcagtatct gggagagacg cagttcgcac cgggccagtg ggctggcgtg    660

gtgctggacg acccggtggg caagaatgat ggcgcggtgg gcggcgtgcg ctacttcgag    720

tgcccggccc tccagggtat cttcacgcgg ccctccaagc tgacccggca gcccacggcc    780

gagggctcgg ggagtgatgc ccactccgtg gagtcgctga ctgcccagaa cctgtcattg    840

cattcgggca cggccacgcc cccgctgacc agccgcgtca tccccctgcg ggagagcgtc    900

ctcaacagct ccgtgaagac tggcaacgag tcgggatcca acctctcaga cagcggctct    960

gtgaagcggg gcgaaaagga cctgcgcctg ggggaccgcg tgctggttgg cgggacgaag   1020

actggcgtgg tgcggtacgt gggggagaca gactttgcca agggcgagtg gtgtggcgtg   1080

gagctggacg agccccttgg gaagaatgat ggggcggtgg cgggcaccag gtacttccag   1140

tgcccaccca agtttggtct cttcgcgccc atccacaaag tgatccgtat cggcttccca   1200

tctaccagcc cagccaaggc caagaagacc aagcgtatgg ccatgggtgt gtcagcactg   1260

acccacagtc ccagcagttc ctccatcagc tccgtcagct ctgtggcctc ctccgtgggg   1320

ggtcggccca gccgcagtgg cctgctcacg gagacctctt cacgctacgc ccgcaagatc   1380

tcgggcacca cggccttgca ggaggcactg aaggagaagc agcagcacat tgagcagctg   1440

ctggctgaac gagacctgga acgggctgag gtggccaagg ccacaagcca catctgcgag   1500

gtggagaagg agattgccct gctcaaggca cagcatgagc agtatgttgc agaagccgag   1560

gagaagctgc agcgagcccg gctgctcgtg gagagcgtgc ggaaagagaa ggtggacctg   1620

tccaaccagc tggaggagga gaggaggaag gtggaggatc tgcagttccg cgtggaggag   1680

gagtccatca ccaagggaga cctggagacc cagacgcagc tggagcacgc gcgcattggg   1740

gagctggaac agagcctgct actggagaag gcgcaggccg agcggctgct ccgagaatta   1800

gcggacaaca ggctgaccac agtggccgag aagtcgcgcg tgctgcagct ggaggaggag   1860

ctcaccctgc gccgaggtga aatcgaggag ctccagcagt gcctgttgca ctcgggtccc   1920

ccacctccgg accacccaga cgccgccgag atcctgcggc tacgggagcg gctgctctcg   1980

gccagcaagg aacaccagag ggagagtggg gtgctgcggg ataaatacga gaaggccctg   2040

aaggcctacc aggcggaggt ggacaagctc cgcgcggcca acgagaagta cgcacaggag   2100

gtggcgggcc tgaaggacaa ggttcagcag gccaccagcg agaacatggg gctaatggac   2160

aactggaaat ccaagctgga ctcgctggcc tcggaccacc agaagtccct ggaggacctc   2220

aaagccaccc tgaactcggg cccaggcgcc cagcagaagg agatcggcga gctgaaggca   2280

gtgatggagg gcatcaagat ggagcaccag ctggagctgg gtaacttgca ggccaagcat   2340

gacctggaga ccgccatgca cgtgaaggag aaggaggccc tgcgagagaa gctgcaggag   2400

gcccaggagg agctggctgg gctgcagcgg cactggcggg cccagctgga ggtgcaagcc   2460

agccagcacc ggctggagct gcaggaggcc caggaccagc gccgggatgc cgagctgcgt   2520

gtgcacgagc tggaaaaact ggacgtggag taccggggcc aggcgcaggc tatcgagttc   2580

ctcaaggagc agatctcgct ggccgagaag aagatgttgg actacgagcg gctgcagcgg   2640

gcagaagccc agggcaaaca ggaggtcgag agtttgcggg agaagctcct ggtggctgag   2700

aacagactcc aggcggtcga ggccctgtgc tcctcccagc acacccacat gattgagtcg   2760

aatgacattt cagaggagac gatcaggacg aaggaaactg tggagggcct gcaggacaag   2820

ctgaacaaga gggacaaaga ggtgacagcc ttgacctccc agaccgagat gctcagggcc   2880

caagtaagtg cgctggagag caagtgtaag tcaggcgaga agaaggtgga cgccctcctg   2940

aaggagaagc ggcgcctgga ggcagagctg gagaccgtgt cccggaagac ccatgacgcc   3000

tcgggccagc tagtcctcat cagccaggag ctgctgcgga aggagcggag cctgaacgaa   3060

ctgcgggtgt tgctgctgga ggccaatcgt cactccccag ggccggagag ggacctgagc   3120

cgtgaggtac acaaggctga gtggcggatc aaggagcaga aactcaagga tgacatccgg   3180

ggcctgcgtg aaaagctgac cgggctggac aaagagaaat ccctgtcgga tcagaggcgc   3240

tactccctca tcgacccgtc ctcggcgccc gagcttctgc ggctgcagca ccagctgatg   3300

agcacggagg acgccctgcg ggatgcgctg gaccaggctc agcaggtgga gaagctgatg   3360

gaggccatga ggagctgccc tgacaaggcc cagaccatcg gcaattccgg ttctgcaaac   3420

ggcatccacc agcaggacaa agctcagaaa caagaggaca agcactgatc ctgaggggat   3480

actgtggagc agcccagtcc acaccagagc cccacgcggc tgcccggcag tacctcctcc   3540

aggcaggagc cgggactgtc actttggaga caaaacagtg tttgtaacaa taacgtactc   3600

accgccgcgg acaatccccc accccgatcc ctcgccagac caggacgctt cctcaagccc   3660

agccttctac agagagtgtg aacggtacag ccccggcctg acccggggac cttcagcctg   3720

gacacccggc agcttctgga gtttgtcagt ggaggcagag gggatccggc caggcccctc   3780

tgtccagaag gagctgccct gaggaccatc ttagcggccc tgtcctcttt ttccgcccat   3840

tctccctcgg gtctccccag aggggccggc gggggctggg gagggggtaa gtttatccat   3900

gcagacacca agggggagca tccagtcttt aagagccaag tgggggcccc ttttccgaag   3960

ccacttccag gccaaggcag tcgccagggc ttcttgtccc caccttctga accttcttca   4020

aacagtagta caagctcccc tcagccagcc tgcctgccca gcgaggcccc caggttcaag   4080

gtgttggcgg gggcggaggg caggggaacg ggatccttct cccgctgccc accaacacca   4140

acacacacac acctctaagc tgctggccga agatgtcacc aaggccaaag acacagtatt   4200

atgaaggttt ggaaacccct ctcctcacct cccaccgtga ccttgggcaa accctggctc   4260

ggagcccagg gcagaggcag ctcagagtgg aggctctagg caggtttgac aaaggtcagt   4320

aatacggttt cccctggggt tgaccagatg ttccaaaata tctgcatcca cctggagatg   4380

cagctaagtg ggtccttatg tacacaccac gttcacacac acacagaggg accacgtgtg   4440

cacgcatgac cgtgtgggtg gcggcgtttg ctgtgaacca cgctcaggcc acacagagac   4500

acatacttgg tttctgggac tgagacccag gcctggcagg accgtgccta cagatactgc   4560

aaacgttcct acagcctaga ggtgcgtata cacacccaag tacacgcagc caggcattca   4620

ggggtgtgtt tgccacatgg agcatccctt cctggtcttg ccaggcacct gcacagagcg   4680

tctccagccc catctcctaa cgggggctgg gggtaagaga aatctaactg cgctccccca   4740

acccctcgcc ctgccatctt cccctcaagc ctgctaagtt atcccaggcc tgtgcgtggt   4800

ggaaaaagcc agccttggcc ctgcagcctc cacctcgccg ctgggggacc aacaggttgc   4860

ttacagcttt gcaccccggc atcagcacag gggtccctgc cccaccctcc ggcagctcag   4920

ggagtgtttt cctgtgaggc ctcccccatc agtggaccag agggagaagc ccgatgcccc   4980

atcccggctt tcccgtaacg cacaggacac gtgtgcaatt cataggaacg gcccagatcg   5040

ccctcatgag tgccacctgg tacaggtagg tggcgctcac gttcctgccc aaatgcagcc   5100

catcggggag tcacagtcag tccccccggc ccccctccca gtccctgttg gctttcggta   5160

gctctcgcat gcagttctat taacagccgt ctagaagcga tgctttagtg gcctaaccca   5220

gggtcaaata cagctctttc tagcaaaatc aggcagctct gccccatcgg taggggcacc   5280

gattagtcta ctaacagcca gaggtccatc tagcagggtg ccgggaggag ctgagccccc   5340

ggaggtgggc tcctggtgac gggtgtccaa gaagcggttt ccttgggagc ttctgcctcc   5400

gtgggcctct cagcccgccc cgtgtggccg cccgggtgtg gctcagccat gtcccctccc   5460

caggtccttc attcacccct cccctcccca cagtggaatt gttgaagtgt ggcgagtctg   5520

tgctcgggac aataaagctt gtgacaggtc caggaccccg gca                     5563


<210>  458
<211>  1046
<212>  PRT
<213>  Homo sapiens

<400>  458

Met Gln Lys Pro Ser Gly Leu Lys Pro Pro Gly Arg Gly Gly Lys His 
1               5                   10                  15


Ser Ser Pro Met Gly Arg Thr Ser Thr Gly Ser Ala Ser Ser Ser Ala 
            20                  25                  30


Ala Val Ala Ala Ser Ser Lys Glu Gly Ser Pro Leu His Lys Gln Ser 
        35                  40                  45


Ser Gly Pro Ser Ser Ser Pro Ala Ala Ala Ala Ala Pro Glu Lys Pro 
    50                  55                  60


Gly Pro Lys Ala Ala Glu Val Gly Asp Asp Phe Leu Gly Asp Phe Val 
65                  70                  75                  80


Val Gly Glu Arg Val Trp Val Asn Gly Val Lys Pro Gly Val Val Gln 
                85                  90                  95


Tyr Leu Gly Glu Thr Gln Phe Ala Pro Gly Gln Trp Ala Gly Val Val 
            100                 105                 110


Leu Asp Asp Pro Val Gly Lys Asn Asp Gly Ala Val Gly Gly Val Arg 
        115                 120                 125


Tyr Phe Glu Cys Pro Ala Leu Gln Gly Ile Phe Thr Arg Pro Ser Lys 
    130                 135                 140


Leu Thr Arg Gln Pro Thr Ala Glu Gly Ser Gly Ser Asp Ala His Ser 
145                 150                 155                 160


Val Glu Ser Leu Thr Ala Gln Asn Leu Ser Leu His Ser Gly Thr Ala 
                165                 170                 175


Thr Pro Pro Leu Thr Ser Arg Val Ile Pro Leu Arg Glu Ser Val Leu 
            180                 185                 190


Asn Ser Ser Val Lys Thr Gly Asn Glu Ser Gly Ser Asn Leu Ser Asp 
        195                 200                 205


Ser Gly Ser Val Lys Arg Gly Glu Lys Asp Leu Arg Leu Gly Asp Arg 
    210                 215                 220


Val Leu Val Gly Gly Thr Lys Thr Gly Val Val Arg Tyr Val Gly Glu 
225                 230                 235                 240


Thr Asp Phe Ala Lys Gly Glu Trp Cys Gly Val Glu Leu Asp Glu Pro 
                245                 250                 255


Leu Gly Lys Asn Asp Gly Ala Val Ala Gly Thr Arg Tyr Phe Gln Cys 
            260                 265                 270


Pro Pro Lys Phe Gly Leu Phe Ala Pro Ile His Lys Val Ile Arg Ile 
        275                 280                 285


Gly Phe Pro Ser Thr Ser Pro Ala Lys Ala Lys Lys Thr Lys Arg Met 
    290                 295                 300


Ala Met Gly Val Ser Ala Leu Thr His Ser Pro Ser Ser Ser Ser Ile 
305                 310                 315                 320


Ser Ser Val Ser Ser Val Ala Ser Ser Val Gly Gly Arg Pro Ser Arg 
                325                 330                 335


Ser Gly Leu Leu Thr Glu Thr Ser Ser Arg Tyr Ala Arg Lys Ile Ser 
            340                 345                 350


Gly Thr Thr Ala Leu Gln Glu Ala Leu Lys Glu Lys Gln Gln His Ile 
        355                 360                 365


Glu Gln Leu Leu Ala Glu Arg Asp Leu Glu Arg Ala Glu Val Ala Lys 
    370                 375                 380


Ala Thr Ser His Ile Cys Glu Val Glu Lys Glu Ile Ala Leu Leu Lys 
385                 390                 395                 400


Ala Gln His Glu Gln Tyr Val Ala Glu Ala Glu Glu Lys Leu Gln Arg 
                405                 410                 415


Ala Arg Leu Leu Val Glu Ser Val Arg Lys Glu Lys Val Asp Leu Ser 
            420                 425                 430


Asn Gln Leu Glu Glu Glu Arg Arg Lys Val Glu Asp Leu Gln Phe Arg 
        435                 440                 445


Val Glu Glu Glu Ser Ile Thr Lys Gly Asp Leu Glu Thr Gln Thr Gln 
    450                 455                 460


Leu Glu His Ala Arg Ile Gly Glu Leu Glu Gln Ser Leu Leu Leu Glu 
465                 470                 475                 480


Lys Ala Gln Ala Glu Arg Leu Leu Arg Glu Leu Ala Asp Asn Arg Leu 
                485                 490                 495


Thr Thr Val Ala Glu Lys Ser Arg Val Leu Gln Leu Glu Glu Glu Leu 
            500                 505                 510


Thr Leu Arg Arg Gly Glu Ile Glu Glu Leu Gln Gln Cys Leu Leu His 
        515                 520                 525


Ser Gly Pro Pro Pro Pro Asp His Pro Asp Ala Ala Glu Ile Leu Arg 
    530                 535                 540


Leu Arg Glu Arg Leu Leu Ser Ala Ser Lys Glu His Gln Arg Glu Ser 
545                 550                 555                 560


Gly Val Leu Arg Asp Lys Tyr Glu Lys Ala Leu Lys Ala Tyr Gln Ala 
                565                 570                 575


Glu Val Asp Lys Leu Arg Ala Ala Asn Glu Lys Tyr Ala Gln Glu Val 
            580                 585                 590


Ala Gly Leu Lys Asp Lys Val Gln Gln Ala Thr Ser Glu Asn Met Gly 
        595                 600                 605


Leu Met Asp Asn Trp Lys Ser Lys Leu Asp Ser Leu Ala Ser Asp His 
    610                 615                 620


Gln Lys Ser Leu Glu Asp Leu Lys Ala Thr Leu Asn Ser Gly Pro Gly 
625                 630                 635                 640


Ala Gln Gln Lys Glu Ile Gly Glu Leu Lys Ala Val Met Glu Gly Ile 
                645                 650                 655


Lys Met Glu His Gln Leu Glu Leu Gly Asn Leu Gln Ala Lys His Asp 
            660                 665                 670


Leu Glu Thr Ala Met His Val Lys Glu Lys Glu Ala Leu Arg Glu Lys 
        675                 680                 685


Leu Gln Glu Ala Gln Glu Glu Leu Ala Gly Leu Gln Arg His Trp Arg 
    690                 695                 700


Ala Gln Leu Glu Val Gln Ala Ser Gln His Arg Leu Glu Leu Gln Glu 
705                 710                 715                 720


Ala Gln Asp Gln Arg Arg Asp Ala Glu Leu Arg Val His Glu Leu Glu 
                725                 730                 735


Lys Leu Asp Val Glu Tyr Arg Gly Gln Ala Gln Ala Ile Glu Phe Leu 
            740                 745                 750


Lys Glu Gln Ile Ser Leu Ala Glu Lys Lys Met Leu Asp Tyr Glu Arg 
        755                 760                 765


Leu Gln Arg Ala Glu Ala Gln Gly Lys Gln Glu Val Glu Ser Leu Arg 
    770                 775                 780


Glu Lys Leu Leu Val Ala Glu Asn Arg Leu Gln Ala Val Glu Ala Leu 
785                 790                 795                 800


Cys Ser Ser Gln His Thr His Met Ile Glu Ser Asn Asp Ile Ser Glu 
                805                 810                 815


Glu Thr Ile Arg Thr Lys Glu Thr Val Glu Gly Leu Gln Asp Lys Leu 
            820                 825                 830


Asn Lys Arg Asp Lys Glu Val Thr Ala Leu Thr Ser Gln Thr Glu Met 
        835                 840                 845


Leu Arg Ala Gln Val Ser Ala Leu Glu Ser Lys Cys Lys Ser Gly Glu 
    850                 855                 860


Lys Lys Val Asp Ala Leu Leu Lys Glu Lys Arg Arg Leu Glu Ala Glu 
865                 870                 875                 880


Leu Glu Thr Val Ser Arg Lys Thr His Asp Ala Ser Gly Gln Leu Val 
                885                 890                 895


Leu Ile Ser Gln Glu Leu Leu Arg Lys Glu Arg Ser Leu Asn Glu Leu 
            900                 905                 910


Arg Val Leu Leu Leu Glu Ala Asn Arg His Ser Pro Gly Pro Glu Arg 
        915                 920                 925


Asp Leu Ser Arg Glu Val His Lys Ala Glu Trp Arg Ile Lys Glu Gln 
    930                 935                 940


Lys Leu Lys Asp Asp Ile Arg Gly Leu Arg Glu Lys Leu Thr Gly Leu 
945                 950                 955                 960


Asp Lys Glu Lys Ser Leu Ser Asp Gln Arg Arg Tyr Ser Leu Ile Asp 
                965                 970                 975


Pro Ser Ser Ala Pro Glu Leu Leu Arg Leu Gln His Gln Leu Met Ser 
            980                 985                 990


Thr Glu Asp Ala Leu Arg Asp Ala Leu Asp Gln Ala Gln Gln Val Glu 
        995                 1000                1005


Lys Leu Met Glu Ala Met Arg Ser Cys Pro Asp Lys Ala Gln Thr Ile 
    1010                1015                1020


Gly Asn Ser Gly Ser Ala Asn Gly Ile His Gln Gln Asp Lys Ala Gln 
1025                1030                1035                1040


Lys Gln Glu Asp Lys His 
                1045


<210>  459
<211>  5458
<212>  DNA
<213>  Homo sapiens

<400>  459
cggctcggcc gcggggcgcg caggcggctg ctgggcggcc tcggtgcgcg cctcccgcct     60

tcccagagac gtggcgcgag gcccgggccc tgagcaccta tcgcggggat ccccggcgcc    120

aggagggggt gcagccggtg ggcagcgccg cgcagggagg ggccgcagca tcctcgcccc    180

ccagcgcgcc cgggcccgag aggaggaggc cggggctctc cgggcctccc gccgcttagc    240

ctgatgctgg aaggacgaag gtgagtgaag atggcagaga ggacgtgacc agcactcacc    300

cttgtccacc tgcccagtgg caccgccatg cagaagccca gcggcctgaa gccccccggc    360

cgtgggggga agcactccag ccccatgggc cggacatcta ctgggtcagc ttcatcctcg    420

gcggcggtgg ccgctagctc caaggaaggc tccccactgc acaaacagtc atctggaccc    480

tcctcctccc cggccgcagc tgctgccccc gagaagccgg gccccaaggc ggcggaagtg    540

ggggatgact tcctggggga ctttgtggtg ggcgagcggg tgtgggtgaa cggcgtgaag    600

ccaggcgtgg tgcagtatct gggagagacg cagttcgcac cgggccagtg ggctggcgtg    660

gtgctggacg acccggtggg caagaatgat ggcgcggtgg gcggcgtgcg ctacttcgag    720

tgcccggccc tccagggtat cttcacgcgg ccctccaagc tgacccggca gcccacggcc    780

gagggctcgg ggagtgatgc ccactccgtg gagtcgctga ctgcccagaa cctgtcattg    840

cattcgggca cggccacgcc cccgctgacc agccgcgtca tccccctgcg ggagagcgtc    900

ctcaacagct ccgtgaagac tggcaacgag tcgggatcca acctctcaga cagcggctct    960

gtgaagcggg gcgaaaagga cctgcgcctg ggggaccgcg tgctggttgg cgggacgaag   1020

actggcgtgg tgcggtacgt gggggagaca gactttgcca agggcgagtg gtgtggcgtg   1080

gagctggacg agccccttgg gaagaatgat ggggcggtgg cgggcaccag gtacttccag   1140

tgcccaccca agtttggtct cttcgcgccc atccacaaag tgatccgtat cggcttccca   1200

tctaccagcc cagccaaggc caagaagacc aagcgtatgg ccatgggtgt gtcagcactg   1260

acccacagtc ccagcagttc ctccatcagc tccgtcagct ctgtggcctc ctccgtgggg   1320

ggtcggccca gccgcagtgg cctgctcacg gagacctctt cacgctacgc ccgcaagatc   1380

tcgggcacca cggccttgca ggaggcactg aaggagaagc agcagcacat tgagcagctg   1440

ctggctgaac gagacctgga acgggctgag gtggccaagg ccacaagcca catctgcgag   1500

gtggagaagg agattgccct gctcaaggca cagcatgagc agtatgttgc agaagccgag   1560

gagaagctgc agcgagcccg gctgctcgtg gagagcgtgc ggaaagagaa ggtggacctg   1620

tccaaccagc tggaggagga gaggaggaag gtggaggatc tgcagttccg cgtggaggag   1680

gagtccatca ccaagggaga cctggagctg accacagtgg ccgagaagtc gcgcgtgctg   1740

cagctggagg aggagctcac cctgcgccga ggtgaaatcg aggagctcca gcagtgcctg   1800

ttgcactcgg gtcccccacc tccggaccac ccagacgccg ccgagatcct gcggctacgg   1860

gagcggctgc tctcggccag caaggaacac cagagggaga gtggggtgct gcgggataaa   1920

tacgagaagg ccctgaaggc ctaccaggcg gaggtggaca agctccgcgc ggccaacgag   1980

aagtacgcac aggaggtggc gggcctgaag gacaaggttc agcaggccac cagcgagaac   2040

atggggctaa tggacaactg gaaatccaag ctggactcgc tggcctcgga ccaccagaag   2100

tccctggagg acctcaaagc caccctgaac tcgggcccag gcgcccagca gaaggagatc   2160

ggcgagctga aggcagtgat ggagggcatc aagatggagc accagctgga gctgggtaac   2220

ttgcaggcca agcatgacct ggagaccgcc atgcacgtga aggagaagga ggccctgcga   2280

gagaagctgc aggaggccca ggaggagctg gctgggctgc agcggcactg gcgggcccag   2340

ctggaggtgc aagccagcca gcaccggctg gagctgcagg aggcccagga ccagcgccgg   2400

gatgccgagc tgcgtgtgca cgagctggaa aaactggacg tggagtaccg gggccaggcg   2460

caggctatcg agttcctcaa ggagcagatc tcgctggccg agaagaagat gttggactac   2520

gagcggctgc agcgggcaga agcccagggc aaacaggagg tcgagagttt gcgggagaag   2580

ctcctggtgg ctgagaacag actccaggcg gtcgaggccc tgtgctcctc ccagcacacc   2640

cacatgattg agtcgaatga catttcagag gagacgatca ggacgaagga aactgtggag   2700

ggcctgcagg acaagctgaa caagagggac aaagaggtga cagccttgac ctcccagacc   2760

gagatgctca gggcccaagt aagtgcgctg gagagcaagt gtaagtcagg cgagaagaag   2820

gtggacgccc tcctgaagga gaagcggcgc ctggaggcag agctggagac cgtgtcccgg   2880

aagacccatg acgcctcggg ccagctagtc ctcatcagcc aggagctgct gcggaaggag   2940

cggagcctga acgaactgcg ggtgttgctg ctggaggcca atcgtcactc cccagggccg   3000

gagagggacc tgagccgtga ggtacacaag gctgagtggc ggatcaagga gcagaaactc   3060

aaggatgaca tccggggcct gcgtgaaaag ctgaccgggc tggacaaaga gaaatccctg   3120

tcggatcaga ggcgctactc cctcatcgac ccgtcctcgg cgcccgagct tctgcggctg   3180

cagcaccagc tgatgagcac ggaggacgcc ctgcgggatg cgctggacca ggctcagcag   3240

gtggagaagc tgatggaggc catgaggagc tgccctgaca aggcccagac catcggcaat   3300

tccggttctg caaacggcat ccaccagcag gacaaagctc agaaacaaga ggacaagcac   3360

tgatcctgag gggatactgt ggagcagccc agtccacacc agagccccac gcggctgccc   3420

ggcagtacct cctccaggca ggagccggga ctgtcacttt ggagacaaaa cagtgtttgt   3480

aacaataacg tactcaccgc cgcggacaat cccccacccc gatccctcgc cagaccagga   3540

cgcttcctca agcccagcct tctacagaga gtgtgaacgg tacagccccg gcctgacccg   3600

gggaccttca gcctggacac ccggcagctt ctggagtttg tcagtggagg cagaggggat   3660

ccggccaggc ccctctgtcc agaaggagct gccctgagga ccatcttagc ggccctgtcc   3720

tctttttccg cccattctcc ctcgggtctc cccagagggg ccggcggggg ctggggaggg   3780

ggtaagttta tccatgcaga caccaagggg gagcatccag tctttaagag ccaagtgggg   3840

gccccttttc cgaagccact tccaggccaa ggcagtcgcc agggcttctt gtccccacct   3900

tctgaacctt cttcaaacag tagtacaagc tcccctcagc cagcctgcct gcccagcgag   3960

gcccccaggt tcaaggtgtt ggcgggggcg gagggcaggg gaacgggatc cttctcccgc   4020

tgcccaccaa caccaacaca cacacacctc taagctgctg gccgaagatg tcaccaaggc   4080

caaagacaca gtattatgaa ggtttggaaa cccctctcct cacctcccac cgtgaccttg   4140

ggcaaaccct ggctcggagc ccagggcaga ggcagctcag agtggaggct ctaggcaggt   4200

ttgacaaagg tcagtaatac ggtttcccct ggggttgacc agatgttcca aaatatctgc   4260

atccacctgg agatgcagct aagtgggtcc ttatgtacac accacgttca cacacacaca   4320

gagggaccac gtgtgcacgc atgaccgtgt gggtggcggc gtttgctgtg aaccacgctc   4380

aggccacaca gagacacata cttggtttct gggactgaga cccaggcctg gcaggaccgt   4440

gcctacagat actgcaaacg ttcctacagc ctagaggtgc gtatacacac ccaagtacac   4500

gcagccaggc attcaggggt gtgtttgcca catggagcat cccttcctgg tcttgccagg   4560

cacctgcaca gagcgtctcc agccccatct cctaacgggg gctgggggta agagaaatct   4620

aactgcgctc ccccaacccc tcgccctgcc atcttcccct caagcctgct aagttatccc   4680

aggcctgtgc gtggtggaaa aagccagcct tggccctgca gcctccacct cgccgctggg   4740

ggaccaacag gttgcttaca gctttgcacc ccggcatcag cacaggggtc cctgccccac   4800

cctccggcag ctcagggagt gttttcctgt gaggcctccc ccatcagtgg accagaggga   4860

gaagcccgat gccccatccc ggctttcccg taacgcacag gacacgtgtg caattcatag   4920

gaacggccca gatcgccctc atgagtgcca cctggtacag gtaggtggcg ctcacgttcc   4980

tgcccaaatg cagcccatcg gggagtcaca gtcagtcccc ccggcccccc tcccagtccc   5040

tgttggcttt cggtagctct cgcatgcagt tctattaaca gccgtctaga agcgatgctt   5100

tagtggccta acccagggtc aaatacagct ctttctagca aaatcaggca gctctgcccc   5160

atcggtaggg gcaccgatta gtctactaac agccagaggt ccatctagca gggtgccggg   5220

aggagctgag cccccggagg tgggctcctg gtgacgggtg tccaagaagc ggtttccttg   5280

ggagcttctg cctccgtggg cctctcagcc cgccccgtgt ggccgcccgg gtgtggctca   5340

gccatgtccc ctccccaggt ccttcattca cccctcccct ccccacagtg gaattgttga   5400

agtgtggcga gtctgtgctc gggacaataa agcttgtgac aggtccagga ccccggca     5458


<210>  460
<211>  1011
<212>  PRT
<213>  Homo sapiens

<400>  460

Met Gln Lys Pro Ser Gly Leu Lys Pro Pro Gly Arg Gly Gly Lys His 
1               5                   10                  15


Ser Ser Pro Met Gly Arg Thr Ser Thr Gly Ser Ala Ser Ser Ser Ala 
            20                  25                  30


Ala Val Ala Ala Ser Ser Lys Glu Gly Ser Pro Leu His Lys Gln Ser 
        35                  40                  45


Ser Gly Pro Ser Ser Ser Pro Ala Ala Ala Ala Ala Pro Glu Lys Pro 
    50                  55                  60


Gly Pro Lys Ala Ala Glu Val Gly Asp Asp Phe Leu Gly Asp Phe Val 
65                  70                  75                  80


Val Gly Glu Arg Val Trp Val Asn Gly Val Lys Pro Gly Val Val Gln 
                85                  90                  95


Tyr Leu Gly Glu Thr Gln Phe Ala Pro Gly Gln Trp Ala Gly Val Val 
            100                 105                 110


Leu Asp Asp Pro Val Gly Lys Asn Asp Gly Ala Val Gly Gly Val Arg 
        115                 120                 125


Tyr Phe Glu Cys Pro Ala Leu Gln Gly Ile Phe Thr Arg Pro Ser Lys 
    130                 135                 140


Leu Thr Arg Gln Pro Thr Ala Glu Gly Ser Gly Ser Asp Ala His Ser 
145                 150                 155                 160


Val Glu Ser Leu Thr Ala Gln Asn Leu Ser Leu His Ser Gly Thr Ala 
                165                 170                 175


Thr Pro Pro Leu Thr Ser Arg Val Ile Pro Leu Arg Glu Ser Val Leu 
            180                 185                 190


Asn Ser Ser Val Lys Thr Gly Asn Glu Ser Gly Ser Asn Leu Ser Asp 
        195                 200                 205


Ser Gly Ser Val Lys Arg Gly Glu Lys Asp Leu Arg Leu Gly Asp Arg 
    210                 215                 220


Val Leu Val Gly Gly Thr Lys Thr Gly Val Val Arg Tyr Val Gly Glu 
225                 230                 235                 240


Thr Asp Phe Ala Lys Gly Glu Trp Cys Gly Val Glu Leu Asp Glu Pro 
                245                 250                 255


Leu Gly Lys Asn Asp Gly Ala Val Ala Gly Thr Arg Tyr Phe Gln Cys 
            260                 265                 270


Pro Pro Lys Phe Gly Leu Phe Ala Pro Ile His Lys Val Ile Arg Ile 
        275                 280                 285


Gly Phe Pro Ser Thr Ser Pro Ala Lys Ala Lys Lys Thr Lys Arg Met 
    290                 295                 300


Ala Met Gly Val Ser Ala Leu Thr His Ser Pro Ser Ser Ser Ser Ile 
305                 310                 315                 320


Ser Ser Val Ser Ser Val Ala Ser Ser Val Gly Gly Arg Pro Ser Arg 
                325                 330                 335


Ser Gly Leu Leu Thr Glu Thr Ser Ser Arg Tyr Ala Arg Lys Ile Ser 
            340                 345                 350


Gly Thr Thr Ala Leu Gln Glu Ala Leu Lys Glu Lys Gln Gln His Ile 
        355                 360                 365


Glu Gln Leu Leu Ala Glu Arg Asp Leu Glu Arg Ala Glu Val Ala Lys 
    370                 375                 380


Ala Thr Ser His Ile Cys Glu Val Glu Lys Glu Ile Ala Leu Leu Lys 
385                 390                 395                 400


Ala Gln His Glu Gln Tyr Val Ala Glu Ala Glu Glu Lys Leu Gln Arg 
                405                 410                 415


Ala Arg Leu Leu Val Glu Ser Val Arg Lys Glu Lys Val Asp Leu Ser 
            420                 425                 430


Asn Gln Leu Glu Glu Glu Arg Arg Lys Val Glu Asp Leu Gln Phe Arg 
        435                 440                 445


Val Glu Glu Glu Ser Ile Thr Lys Gly Asp Leu Glu Leu Thr Thr Val 
    450                 455                 460


Ala Glu Lys Ser Arg Val Leu Gln Leu Glu Glu Glu Leu Thr Leu Arg 
465                 470                 475                 480


Arg Gly Glu Ile Glu Glu Leu Gln Gln Cys Leu Leu His Ser Gly Pro 
                485                 490                 495


Pro Pro Pro Asp His Pro Asp Ala Ala Glu Ile Leu Arg Leu Arg Glu 
            500                 505                 510


Arg Leu Leu Ser Ala Ser Lys Glu His Gln Arg Glu Ser Gly Val Leu 
        515                 520                 525


Arg Asp Lys Tyr Glu Lys Ala Leu Lys Ala Tyr Gln Ala Glu Val Asp 
    530                 535                 540


Lys Leu Arg Ala Ala Asn Glu Lys Tyr Ala Gln Glu Val Ala Gly Leu 
545                 550                 555                 560


Lys Asp Lys Val Gln Gln Ala Thr Ser Glu Asn Met Gly Leu Met Asp 
                565                 570                 575


Asn Trp Lys Ser Lys Leu Asp Ser Leu Ala Ser Asp His Gln Lys Ser 
            580                 585                 590


Leu Glu Asp Leu Lys Ala Thr Leu Asn Ser Gly Pro Gly Ala Gln Gln 
        595                 600                 605


Lys Glu Ile Gly Glu Leu Lys Ala Val Met Glu Gly Ile Lys Met Glu 
    610                 615                 620


His Gln Leu Glu Leu Gly Asn Leu Gln Ala Lys His Asp Leu Glu Thr 
625                 630                 635                 640


Ala Met His Val Lys Glu Lys Glu Ala Leu Arg Glu Lys Leu Gln Glu 
                645                 650                 655


Ala Gln Glu Glu Leu Ala Gly Leu Gln Arg His Trp Arg Ala Gln Leu 
            660                 665                 670


Glu Val Gln Ala Ser Gln His Arg Leu Glu Leu Gln Glu Ala Gln Asp 
        675                 680                 685


Gln Arg Arg Asp Ala Glu Leu Arg Val His Glu Leu Glu Lys Leu Asp 
    690                 695                 700


Val Glu Tyr Arg Gly Gln Ala Gln Ala Ile Glu Phe Leu Lys Glu Gln 
705                 710                 715                 720


Ile Ser Leu Ala Glu Lys Lys Met Leu Asp Tyr Glu Arg Leu Gln Arg 
                725                 730                 735


Ala Glu Ala Gln Gly Lys Gln Glu Val Glu Ser Leu Arg Glu Lys Leu 
            740                 745                 750


Leu Val Ala Glu Asn Arg Leu Gln Ala Val Glu Ala Leu Cys Ser Ser 
        755                 760                 765


Gln His Thr His Met Ile Glu Ser Asn Asp Ile Ser Glu Glu Thr Ile 
    770                 775                 780


Arg Thr Lys Glu Thr Val Glu Gly Leu Gln Asp Lys Leu Asn Lys Arg 
785                 790                 795                 800


Asp Lys Glu Val Thr Ala Leu Thr Ser Gln Thr Glu Met Leu Arg Ala 
                805                 810                 815


Gln Val Ser Ala Leu Glu Ser Lys Cys Lys Ser Gly Glu Lys Lys Val 
            820                 825                 830


Asp Ala Leu Leu Lys Glu Lys Arg Arg Leu Glu Ala Glu Leu Glu Thr 
        835                 840                 845


Val Ser Arg Lys Thr His Asp Ala Ser Gly Gln Leu Val Leu Ile Ser 
    850                 855                 860


Gln Glu Leu Leu Arg Lys Glu Arg Ser Leu Asn Glu Leu Arg Val Leu 
865                 870                 875                 880


Leu Leu Glu Ala Asn Arg His Ser Pro Gly Pro Glu Arg Asp Leu Ser 
                885                 890                 895


Arg Glu Val His Lys Ala Glu Trp Arg Ile Lys Glu Gln Lys Leu Lys 
            900                 905                 910


Asp Asp Ile Arg Gly Leu Arg Glu Lys Leu Thr Gly Leu Asp Lys Glu 
        915                 920                 925


Lys Ser Leu Ser Asp Gln Arg Arg Tyr Ser Leu Ile Asp Pro Ser Ser 
    930                 935                 940


Ala Pro Glu Leu Leu Arg Leu Gln His Gln Leu Met Ser Thr Glu Asp 
945                 950                 955                 960


Ala Leu Arg Asp Ala Leu Asp Gln Ala Gln Gln Val Glu Lys Leu Met 
                965                 970                 975


Glu Ala Met Arg Ser Cys Pro Asp Lys Ala Gln Thr Ile Gly Asn Ser 
            980                 985                 990


Gly Ser Ala Asn Gly Ile His Gln Gln Asp Lys Ala Gln Lys Gln Glu 
        995                 1000                1005


Asp Lys His 
    1010


<210>  461
<211>  3078
<212>  DNA
<213>  Homo sapiens

<400>  461
aggaggctga gtcctggccg cgggccgggg ccggggcgcc gctggcagga gcgcttgggg     60

atcctccaag gcgaccatgg ccttgctggg taagcgctgt gacgtcccca ccaacggctg    120

cggacccgac cgctggaact ccgcgttcac ccgcaaagac gagatcatca ccagcctcgt    180

gtctgcctta gactccatgt gctcagcgct gtccaaactg aacgccgagg tggcctgtgt    240

cgccgtgcac gatgagagcg cctttgtggt gggcacagag aaggggagaa tgttcctgaa    300

tgcccggaag gagctacagt cagacttcct caggttctgc cgagggcccc cgtggaagga    360

tccggaggca gagcacccca agaaggtgca gcggggcgag ggtggaggcc gtagcctccc    420

tcggtcctcc ctggaacatg gctcagatgt gtaccttctg cggaagatgg tagaggaggt    480

gtttgatgtt ctttatagcg aggccctggg aagggccagt gtggtgccac tgccctatga    540

gaggctgctc agggagccag ggctgctggc cgtgcagggg ctgcccgaag gcctggcctt    600

ccgaaggcca gccgagtatg accccaaggc cctcatggcc atcctggaac acagccaccg    660

catccgcttc aagctcaaga ggccacttga ggatggcggg cgggactcga aggccctggt    720

ggagctgaac ggtgtctccc tgattcccaa ggggtcacgg gactgtggcc tgcatggcca    780

ggcccccaag gtgccacccc aggacctgcc cccaaccgcc acctcctcct ccatggccag    840

cttcctgtac agcacggcgc tccccaacca cgccatccga gagctcaagc aggaagcacc    900

ttcctgcccc cttgccccca gcgacctggg cctgagtcgg cccatgccag agcccaaggc    960

caccggtgcc caagacttct ccgactgttg tggacagaag cccactgggc ctggtgggcc   1020

tctcatccag aacgtccatg cctccaagcg cattctcttc tccatcgtcc atgacaagtc   1080

agagaagtgg gacgccttca taaaggaaac cgaggacatc aacacgctcc gggagtgtgt   1140

gcagatcctg tttaacagca gatatgcgga agccctgggc ctggaccaca tggtccccgt   1200

gccctaccgg aagattgcct gtgacccgga ggctgtggag atcgtgggca tcccggacaa   1260

gatccccttc aagcgcccct gcacttatgg agtccccaag ctgaagcgga tcctggagga   1320

gcgccatagt atccacttca tcattaagag gatgtttgat gagcgaattt tcacagggaa   1380

caagtttacc aaagacacca cgaagctgga gccagccagc ccgccagagg acacctctgc   1440

agaggtctct agggccaccg tccttgacct tgctgggaat gctcggtcag acaagggcag   1500

catgtctgaa gactgtgggc caggaacctc cggggagctg ggcgggctga ggccgatcaa   1560

aattgagcca gaggatctgg acatcattca ggtcaccgtc ccagacccct cgccaacctc   1620

tgaggaaatg acagactcga tgcctgggca cctgccatcg gaggattctg gttatgggat   1680

ggagatgctg acagacaaag gtctgagtga ggacgcgcgg cccgaggaga ggcccgtgga   1740

ggacagccac ggtgacgtga tccggcccct gcggaagcag gtggagctgc tcttcaacac   1800

acgatacgcc aaggccattg gcatctcgga gcccgtcaag gtgccgtact ccaagtttct   1860

gatgcacccg gaggagctgt ttgtggtggg actgcctgaa ggcatctccc tccgcaggcc   1920

caactgcttc gggatcgcca agctccggaa gattctggag gccagcaaca gcatccagtt   1980

tgtcatcaag aggcccgagc tgctcactga gggagtcaaa gagcccatcg tggatagtca   2040

agagagggat tccggggacc ctctggtgga cgagagcctg aagagacagg gctttcaaga   2100

aaattatgac gcgaggctct cacggatcga catcgccaac acactaaggg agcaggtcca   2160

ggaccttttc aataagaaat acggggaagc cttgggcatc aagtacccgg tccaggtccc   2220

ctacaagcgg atcaagagta accccggctc cgtgatcatc gaggggctgc ccccaggaat   2280

cccgttccga aagccctgta ccttcggctc ccagaacctg gagaggattc ttgctgtggc   2340

tgacaagatc aagttcacag tcaccaggcc tttccaagga ctcatcccaa agcctgatga   2400

agatgacgcc aacagactcg gggagaaggt gatcctgcgg gagcaggtga aggaactctt   2460

caacgagaaa tacggtgagg ccctgggcct gaaccggccg gtgctggtcc cttataaact   2520

aatccgggac agcccagacg ccgtggaggt cacgggtctg cctgatgaca tccccttccg   2580

gaaccccaac acgtacgaca tccaccggct ggagaagatc ctgaaggccc gagagcatgt   2640

ccgcatggtc atcattaacc agctccaacc ctttgcagaa atctgcaatg atgccaaggt   2700

gccagccaaa gacagcagca ttcccaagcg caagagaaag cgggtctcgg aaggaaattc   2760

cgtctcctct tcctcctcgt cttcctcttc ctcgtcctct aacccggatt cagtggcatc   2820

ggccaaccag atctcactcg tgcaatggcc aatgtacatg gtggactatg ccggcctgaa   2880

cgtgcagctc ccgggacctc ttaattacta gacctcagta ctgaatcagg acctcactca   2940

gaaagactaa aggaaatgta atttatgtac aaaatgtata ttcggatatg tatcgatgcc   3000

ttttagtttt tccaatgatt tttacactat attcctgcca ccaaggcctt tttaaataag   3060

taaaaaaaaa aaaaaaaa                                                 3078


<210>  462
<211>  944
<212>  PRT
<213>  Homo sapiens

<400>  462

Met Ala Leu Leu Gly Lys Arg Cys Asp Val Pro Thr Asn Gly Cys Gly 
1               5                   10                  15


Pro Asp Arg Trp Asn Ser Ala Phe Thr Arg Lys Asp Glu Ile Ile Thr 
            20                  25                  30


Ser Leu Val Ser Ala Leu Asp Ser Met Cys Ser Ala Leu Ser Lys Leu 
        35                  40                  45


Asn Ala Glu Val Ala Cys Val Ala Val His Asp Glu Ser Ala Phe Val 
    50                  55                  60


Val Gly Thr Glu Lys Gly Arg Met Phe Leu Asn Ala Arg Lys Glu Leu 
65                  70                  75                  80


Gln Ser Asp Phe Leu Arg Phe Cys Arg Gly Pro Pro Trp Lys Asp Pro 
                85                  90                  95


Glu Ala Glu His Pro Lys Lys Val Gln Arg Gly Glu Gly Gly Gly Arg 
            100                 105                 110


Ser Leu Pro Arg Ser Ser Leu Glu His Gly Ser Asp Val Tyr Leu Leu 
        115                 120                 125


Arg Lys Met Val Glu Glu Val Phe Asp Val Leu Tyr Ser Glu Ala Leu 
    130                 135                 140


Gly Arg Ala Ser Val Val Pro Leu Pro Tyr Glu Arg Leu Leu Arg Glu 
145                 150                 155                 160


Pro Gly Leu Leu Ala Val Gln Gly Leu Pro Glu Gly Leu Ala Phe Arg 
                165                 170                 175


Arg Pro Ala Glu Tyr Asp Pro Lys Ala Leu Met Ala Ile Leu Glu His 
            180                 185                 190


Ser His Arg Ile Arg Phe Lys Leu Lys Arg Pro Leu Glu Asp Gly Gly 
        195                 200                 205


Arg Asp Ser Lys Ala Leu Val Glu Leu Asn Gly Val Ser Leu Ile Pro 
    210                 215                 220


Lys Gly Ser Arg Asp Cys Gly Leu His Gly Gln Ala Pro Lys Val Pro 
225                 230                 235                 240


Pro Gln Asp Leu Pro Pro Thr Ala Thr Ser Ser Ser Met Ala Ser Phe 
                245                 250                 255


Leu Tyr Ser Thr Ala Leu Pro Asn His Ala Ile Arg Glu Leu Lys Gln 
            260                 265                 270


Glu Ala Pro Ser Cys Pro Leu Ala Pro Ser Asp Leu Gly Leu Ser Arg 
        275                 280                 285


Pro Met Pro Glu Pro Lys Ala Thr Gly Ala Gln Asp Phe Ser Asp Cys 
    290                 295                 300


Cys Gly Gln Lys Pro Thr Gly Pro Gly Gly Pro Leu Ile Gln Asn Val 
305                 310                 315                 320


His Ala Ser Lys Arg Ile Leu Phe Ser Ile Val His Asp Lys Ser Glu 
                325                 330                 335


Lys Trp Asp Ala Phe Ile Lys Glu Thr Glu Asp Ile Asn Thr Leu Arg 
            340                 345                 350


Glu Cys Val Gln Ile Leu Phe Asn Ser Arg Tyr Ala Glu Ala Leu Gly 
        355                 360                 365


Leu Asp His Met Val Pro Val Pro Tyr Arg Lys Ile Ala Cys Asp Pro 
    370                 375                 380


Glu Ala Val Glu Ile Val Gly Ile Pro Asp Lys Ile Pro Phe Lys Arg 
385                 390                 395                 400


Pro Cys Thr Tyr Gly Val Pro Lys Leu Lys Arg Ile Leu Glu Glu Arg 
                405                 410                 415


His Ser Ile His Phe Ile Ile Lys Arg Met Phe Asp Glu Arg Ile Phe 
            420                 425                 430


Thr Gly Asn Lys Phe Thr Lys Asp Thr Thr Lys Leu Glu Pro Ala Ser 
        435                 440                 445


Pro Pro Glu Asp Thr Ser Ala Glu Val Ser Arg Ala Thr Val Leu Asp 
    450                 455                 460


Leu Ala Gly Asn Ala Arg Ser Asp Lys Gly Ser Met Ser Glu Asp Cys 
465                 470                 475                 480


Gly Pro Gly Thr Ser Gly Glu Leu Gly Gly Leu Arg Pro Ile Lys Ile 
                485                 490                 495


Glu Pro Glu Asp Leu Asp Ile Ile Gln Val Thr Val Pro Asp Pro Ser 
            500                 505                 510


Pro Thr Ser Glu Glu Met Thr Asp Ser Met Pro Gly His Leu Pro Ser 
        515                 520                 525


Glu Asp Ser Gly Tyr Gly Met Glu Met Leu Thr Asp Lys Gly Leu Ser 
    530                 535                 540


Glu Asp Ala Arg Pro Glu Glu Arg Pro Val Glu Asp Ser His Gly Asp 
545                 550                 555                 560


Val Ile Arg Pro Leu Arg Lys Gln Val Glu Leu Leu Phe Asn Thr Arg 
                565                 570                 575


Tyr Ala Lys Ala Ile Gly Ile Ser Glu Pro Val Lys Val Pro Tyr Ser 
            580                 585                 590


Lys Phe Leu Met His Pro Glu Glu Leu Phe Val Val Gly Leu Pro Glu 
        595                 600                 605


Gly Ile Ser Leu Arg Arg Pro Asn Cys Phe Gly Ile Ala Lys Leu Arg 
    610                 615                 620


Lys Ile Leu Glu Ala Ser Asn Ser Ile Gln Phe Val Ile Lys Arg Pro 
625                 630                 635                 640


Glu Leu Leu Thr Glu Gly Val Lys Glu Pro Ile Val Asp Ser Gln Glu 
                645                 650                 655


Arg Asp Ser Gly Asp Pro Leu Val Asp Glu Ser Leu Lys Arg Gln Gly 
            660                 665                 670


Phe Gln Glu Asn Tyr Asp Ala Arg Leu Ser Arg Ile Asp Ile Ala Asn 
        675                 680                 685


Thr Leu Arg Glu Gln Val Gln Asp Leu Phe Asn Lys Lys Tyr Gly Glu 
    690                 695                 700


Ala Leu Gly Ile Lys Tyr Pro Val Gln Val Pro Tyr Lys Arg Ile Lys 
705                 710                 715                 720


Ser Asn Pro Gly Ser Val Ile Ile Glu Gly Leu Pro Pro Gly Ile Pro 
                725                 730                 735


Phe Arg Lys Pro Cys Thr Phe Gly Ser Gln Asn Leu Glu Arg Ile Leu 
            740                 745                 750


Ala Val Ala Asp Lys Ile Lys Phe Thr Val Thr Arg Pro Phe Gln Gly 
        755                 760                 765


Leu Ile Pro Lys Pro Asp Glu Asp Asp Ala Asn Arg Leu Gly Glu Lys 
    770                 775                 780


Val Ile Leu Arg Glu Gln Val Lys Glu Leu Phe Asn Glu Lys Tyr Gly 
785                 790                 795                 800


Glu Ala Leu Gly Leu Asn Arg Pro Val Leu Val Pro Tyr Lys Leu Ile 
                805                 810                 815


Arg Asp Ser Pro Asp Ala Val Glu Val Thr Gly Leu Pro Asp Asp Ile 
            820                 825                 830


Pro Phe Arg Asn Pro Asn Thr Tyr Asp Ile His Arg Leu Glu Lys Ile 
        835                 840                 845


Leu Lys Ala Arg Glu His Val Arg Met Val Ile Ile Asn Gln Leu Gln 
    850                 855                 860


Pro Phe Ala Glu Ile Cys Asn Asp Ala Lys Val Pro Ala Lys Asp Ser 
865                 870                 875                 880


Ser Ile Pro Lys Arg Lys Arg Lys Arg Val Ser Glu Gly Asn Ser Val 
                885                 890                 895


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Asn Pro Asp Ser 
            900                 905                 910


Val Ala Ser Ala Asn Gln Ile Ser Leu Val Gln Trp Pro Met Tyr Met 
        915                 920                 925


Val Asp Tyr Ala Gly Leu Asn Val Gln Leu Pro Gly Pro Leu Asn Tyr 
    930                 935                 940


<210>  463
<211>  3446
<212>  DNA
<213>  Homo sapiens

<400>  463
taaatggcag ccaatggagg gtggtgttgc gcggggctgg gattagggcc ggggcgaatg     60

gctggcaatc ttactgggat tacagaacaa agagcctccc cgcgctcccg ctctccgctc    120

ctctccccgc gccgccccgc cctccgccgc agcccgcgcc gggggtgggg gccgccgagc    180

gccagccccc cggccggccg attccccccc cgcgccccct ccccgcgcct ccctccccgc    240

cctcgccgcg ccgccgtcct cgcctccctc tgcctctcct tcccccattc tcccggatta    300

attaaggagg cagcggcagg aggctgagtc ctggccgcgg gccggggccg gggcgccgct    360

ggcaggagcg cttggggatc ctccaaggcg accatggcct tgctgggtaa gcgctgtgac    420

gtccccacca acggctgcgg acccgaccgc tggaactccg cgttcacccg caaagacgag    480

atcatcacca gcctcgtgtc tgccttagac tccatgtgct cagcgctgtc caaactgaac    540

gccgaggtgg cctgtgtcgc cgtgcacgat gagagcgcct ttgtggtggg cacagagaag    600

gggagaatgt tcctgaatgc ccggaaggag ctacagtcag acttcctcag gttctgccga    660

gggcccccgt ggaaggatcc ggaggcagag caccccaaga aggtgcagcg gggcgagggt    720

ggaggccgta gcctccctcg gtcctccctg gaacatggct cagatgtgta ccttctgcgg    780

aagatggtag aggaggtgtt tgatgttctt tatagcgagg ccctgggaag ggccagtgtg    840

gtgccactgc cctatgagag gctgctcagg gagccagggc tgctggccgt gcaggggctg    900

cccgaaggcc tggccttccg aaggccagcc gagtatgacc ccaaggccct catggccatc    960

ctggaacaca gccaccgcat ccgcttcaag ctcaagaggc cacttgagga tggcgggcgg   1020

gactcgaagg ccctggtgga gctgaacggt gtctccctga ttcccaaggg gtcacgggac   1080

tgtggcctgc atggccaggc ccccaaggtg ccaccccagg acctgccccc aaccgccacc   1140

tcctcctcca tggccagctt cctgtacagc acggcgctcc ccaaccacgc catccgagag   1200

ctcaagcagg aagcaccttc ctgccccctt gcccccagcg acctgggcct gagtcggccc   1260

atgccagagc ccaaggccac cggtgcccaa gacttctccg actgttgtgg acagaagccc   1320

actgggcctg gtgggcctct catccagaac gtccatgcct ccaagcgcat tctcttctcc   1380

atcgtccatg acaagtcaga gaagtgggac gccttcataa aggaaaccga ggacatcaac   1440

acgctccggg agtgtgtgca gatcctgttt aacagcagat atgcggaagc cctgggcctg   1500

gaccacatgg tccccgtgcc ctaccggaag attgcctgtg acccggaggc tgtggagatc   1560

gtgggcatcc cggacaagat ccccttcaag cgcccctgca cttatggagt ccccaagctg   1620

aagcggatcc tggaggagcg ccatagtatc cacttcatca ttaagaggat gtttgatgag   1680

cgaattttca cagggaacaa gtttaccaaa gacaccacga agctggagcc agccagcccg   1740

ccagaggaca cctctgcaga ggtctctagg gccaccgtcc ttgaccttgc tgggaatgct   1800

cggtcagaca agggcagcat gtctgaagac tgtgggccag gaacctccgg ggagctgggc   1860

gggctgaggc cgatcaaaat tgagccagag gatctggaca tcattcaggt caccgtccca   1920

gacccctcgc caacctctga ggaaatgaca gactcgatgc ctgggcacct gccatcggag   1980

gattctggtt atgggatgga gatgctgaca gacaaaggtc tgagtgagga cgcgcggccg   2040

gaggagaggc ccgtggagga cagccacggt gacgtgatcc ggcccctgcg gaagcaggtg   2100

gagctgctct tcaacacacg atacgccaag gccattggca tctcggagcc cgtcaaggtg   2160

ccgtactcca agtttctgat gcacccggag gagctgtttg tggtgggact gcctgaaggc   2220

atctccctcc gcaggcccaa ctgcttcggg atcgccaagc tccggaagat tctggaggcc   2280

agcaacagca tccagtttgt catcaagagg cccgagctgc tcactgaggg agtcaaagag   2340

cccatcatgg atagtcaagg aactgcctcc tcacttggct tctctccccc tgccctgccc   2400

ccagagaggg attccgggga ccctctggtg gacgagagcc tgaagagaca gggctttcaa   2460

gaaaattatg acgcgaggct ctcacggatc gacatcgcca acacactaag ggagcaggtc   2520

caggaccttt tcaataagaa atacggggaa gccttgggca tcaagtaccc ggtccaggtc   2580

ccctacaagc ggatcaagag taaccccggc tccgtgatca tcgaggggct gcccccagga   2640

atcccgttcc gaaagccctg taccttcggc tcccagaacc tggagaggat tcttgctgtg   2700

gctgacaaga tcaagttcac agtcaccagg cctttccaag gactcatccc aaagcctgat   2760

gaagatgacg ccaacagact cggggagaag gtgatcctgc gggagcaggt gaaggaactc   2820

ttcaacgaga aatacggtga ggccctgggc ctgaaccggc cggtgctggt cccttataaa   2880

ctaatccggg acagcccaga cgccgtggag gtcacgggtc tgcctgatga catccccttc   2940

cggaacccca acacgtacga catccaccgg ctggagaaga tcctgaaggc ccgagagcat   3000

gtccgcatgg tcatcattaa ccagctccaa ccctttgcag aaatctgcaa tgatgccaag   3060

gtgccagcca aagacagcag cattcccaag cgcaagagaa agcgggtctc ggaaggaaat   3120

tccgtctcct cttcctcctc gtcttcctct tcctcgtcct ctaacccgga ttcagtggca   3180

tcggccaacc agatctcact cgtgcaatgg ccaatgtaca tggtggacta tgccggcctg   3240

aacgtgcagc tcccgggacc tcttaattac tagacctcag tactgaatca ggacctcact   3300

cagaaagact aaaggaaatg taatttatgt acaaaatgta tattcggata tgtatcgatg   3360

ccttttagtt tttccaatga tttttacact atattcctgc caccaaggcc tttttaaata   3420

agtaaaaaaa aaaaaaaaaa aaaaaa                                        3446


<210>  464
<211>  959
<212>  PRT
<213>  Homo sapiens

<400>  464

Met Ala Leu Leu Gly Lys Arg Cys Asp Val Pro Thr Asn Gly Cys Gly 
1               5                   10                  15


Pro Asp Arg Trp Asn Ser Ala Phe Thr Arg Lys Asp Glu Ile Ile Thr 
            20                  25                  30


Ser Leu Val Ser Ala Leu Asp Ser Met Cys Ser Ala Leu Ser Lys Leu 
        35                  40                  45


Asn Ala Glu Val Ala Cys Val Ala Val His Asp Glu Ser Ala Phe Val 
    50                  55                  60


Val Gly Thr Glu Lys Gly Arg Met Phe Leu Asn Ala Arg Lys Glu Leu 
65                  70                  75                  80


Gln Ser Asp Phe Leu Arg Phe Cys Arg Gly Pro Pro Trp Lys Asp Pro 
                85                  90                  95


Glu Ala Glu His Pro Lys Lys Val Gln Arg Gly Glu Gly Gly Gly Arg 
            100                 105                 110


Ser Leu Pro Arg Ser Ser Leu Glu His Gly Ser Asp Val Tyr Leu Leu 
        115                 120                 125


Arg Lys Met Val Glu Glu Val Phe Asp Val Leu Tyr Ser Glu Ala Leu 
    130                 135                 140


Gly Arg Ala Ser Val Val Pro Leu Pro Tyr Glu Arg Leu Leu Arg Glu 
145                 150                 155                 160


Pro Gly Leu Leu Ala Val Gln Gly Leu Pro Glu Gly Leu Ala Phe Arg 
                165                 170                 175


Arg Pro Ala Glu Tyr Asp Pro Lys Ala Leu Met Ala Ile Leu Glu His 
            180                 185                 190


Ser His Arg Ile Arg Phe Lys Leu Lys Arg Pro Leu Glu Asp Gly Gly 
        195                 200                 205


Arg Asp Ser Lys Ala Leu Val Glu Leu Asn Gly Val Ser Leu Ile Pro 
    210                 215                 220


Lys Gly Ser Arg Asp Cys Gly Leu His Gly Gln Ala Pro Lys Val Pro 
225                 230                 235                 240


Pro Gln Asp Leu Pro Pro Thr Ala Thr Ser Ser Ser Met Ala Ser Phe 
                245                 250                 255


Leu Tyr Ser Thr Ala Leu Pro Asn His Ala Ile Arg Glu Leu Lys Gln 
            260                 265                 270


Glu Ala Pro Ser Cys Pro Leu Ala Pro Ser Asp Leu Gly Leu Ser Arg 
        275                 280                 285


Pro Met Pro Glu Pro Lys Ala Thr Gly Ala Gln Asp Phe Ser Asp Cys 
    290                 295                 300


Cys Gly Gln Lys Pro Thr Gly Pro Gly Gly Pro Leu Ile Gln Asn Val 
305                 310                 315                 320


His Ala Ser Lys Arg Ile Leu Phe Ser Ile Val His Asp Lys Ser Glu 
                325                 330                 335


Lys Trp Asp Ala Phe Ile Lys Glu Thr Glu Asp Ile Asn Thr Leu Arg 
            340                 345                 350


Glu Cys Val Gln Ile Leu Phe Asn Ser Arg Tyr Ala Glu Ala Leu Gly 
        355                 360                 365


Leu Asp His Met Val Pro Val Pro Tyr Arg Lys Ile Ala Cys Asp Pro 
    370                 375                 380


Glu Ala Val Glu Ile Val Gly Ile Pro Asp Lys Ile Pro Phe Lys Arg 
385                 390                 395                 400


Pro Cys Thr Tyr Gly Val Pro Lys Leu Lys Arg Ile Leu Glu Glu Arg 
                405                 410                 415


His Ser Ile His Phe Ile Ile Lys Arg Met Phe Asp Glu Arg Ile Phe 
            420                 425                 430


Thr Gly Asn Lys Phe Thr Lys Asp Thr Thr Lys Leu Glu Pro Ala Ser 
        435                 440                 445


Pro Pro Glu Asp Thr Ser Ala Glu Val Ser Arg Ala Thr Val Leu Asp 
    450                 455                 460


Leu Ala Gly Asn Ala Arg Ser Asp Lys Gly Ser Met Ser Glu Asp Cys 
465                 470                 475                 480


Gly Pro Gly Thr Ser Gly Glu Leu Gly Gly Leu Arg Pro Ile Lys Ile 
                485                 490                 495


Glu Pro Glu Asp Leu Asp Ile Ile Gln Val Thr Val Pro Asp Pro Ser 
            500                 505                 510


Pro Thr Ser Glu Glu Met Thr Asp Ser Met Pro Gly His Leu Pro Ser 
        515                 520                 525


Glu Asp Ser Gly Tyr Gly Met Glu Met Leu Thr Asp Lys Gly Leu Ser 
    530                 535                 540


Glu Asp Ala Arg Pro Glu Glu Arg Pro Val Glu Asp Ser His Gly Asp 
545                 550                 555                 560


Val Ile Arg Pro Leu Arg Lys Gln Val Glu Leu Leu Phe Asn Thr Arg 
                565                 570                 575


Tyr Ala Lys Ala Ile Gly Ile Ser Glu Pro Val Lys Val Pro Tyr Ser 
            580                 585                 590


Lys Phe Leu Met His Pro Glu Glu Leu Phe Val Val Gly Leu Pro Glu 
        595                 600                 605


Gly Ile Ser Leu Arg Arg Pro Asn Cys Phe Gly Ile Ala Lys Leu Arg 
    610                 615                 620


Lys Ile Leu Glu Ala Ser Asn Ser Ile Gln Phe Val Ile Lys Arg Pro 
625                 630                 635                 640


Glu Leu Leu Thr Glu Gly Val Lys Glu Pro Ile Met Asp Ser Gln Gly 
                645                 650                 655


Thr Ala Ser Ser Leu Gly Phe Ser Pro Pro Ala Leu Pro Pro Glu Arg 
            660                 665                 670


Asp Ser Gly Asp Pro Leu Val Asp Glu Ser Leu Lys Arg Gln Gly Phe 
        675                 680                 685


Gln Glu Asn Tyr Asp Ala Arg Leu Ser Arg Ile Asp Ile Ala Asn Thr 
    690                 695                 700


Leu Arg Glu Gln Val Gln Asp Leu Phe Asn Lys Lys Tyr Gly Glu Ala 
705                 710                 715                 720


Leu Gly Ile Lys Tyr Pro Val Gln Val Pro Tyr Lys Arg Ile Lys Ser 
                725                 730                 735


Asn Pro Gly Ser Val Ile Ile Glu Gly Leu Pro Pro Gly Ile Pro Phe 
            740                 745                 750


Arg Lys Pro Cys Thr Phe Gly Ser Gln Asn Leu Glu Arg Ile Leu Ala 
        755                 760                 765


Val Ala Asp Lys Ile Lys Phe Thr Val Thr Arg Pro Phe Gln Gly Leu 
    770                 775                 780


Ile Pro Lys Pro Asp Glu Asp Asp Ala Asn Arg Leu Gly Glu Lys Val 
785                 790                 795                 800


Ile Leu Arg Glu Gln Val Lys Glu Leu Phe Asn Glu Lys Tyr Gly Glu 
                805                 810                 815


Ala Leu Gly Leu Asn Arg Pro Val Leu Val Pro Tyr Lys Leu Ile Arg 
            820                 825                 830


Asp Ser Pro Asp Ala Val Glu Val Thr Gly Leu Pro Asp Asp Ile Pro 
        835                 840                 845


Phe Arg Asn Pro Asn Thr Tyr Asp Ile His Arg Leu Glu Lys Ile Leu 
    850                 855                 860


Lys Ala Arg Glu His Val Arg Met Val Ile Ile Asn Gln Leu Gln Pro 
865                 870                 875                 880


Phe Ala Glu Ile Cys Asn Asp Ala Lys Val Pro Ala Lys Asp Ser Ser 
                885                 890                 895


Ile Pro Lys Arg Lys Arg Lys Arg Val Ser Glu Gly Asn Ser Val Ser 
            900                 905                 910


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Asn Pro Asp Ser Val 
        915                 920                 925


Ala Ser Ala Asn Gln Ile Ser Leu Val Gln Trp Pro Met Tyr Met Val 
    930                 935                 940


Asp Tyr Ala Gly Leu Asn Val Gln Leu Pro Gly Pro Leu Asn Tyr 
945                 950                 955


<210>  465
<211>  4422
<212>  DNA
<213>  Homo sapiens

<400>  465
aggaggagga gggtgagaga gaagctggga gagcagagaa aaggggccac cggtcgcccc     60

cccgcttccc cgcacgcgct ctccagccgc ggccgcccgc ctgccgcggt caccccggcc    120

tctgcctctg tcccccagtg atcggatcaa ggcgctgagc gaggccctgc ctgcggggcg    180

gccatgcggc ggtgacagga gcgcgaccga cacgcacggg cccctcgccc cctctcgcct    240

cccgtccgct cgccagctcc cctcagccga ggctgctccg cggcggccgc agcccgcgcg    300

cggcccacac tcgcctcccc tcggcacccc cggccccgga gctgcctgga ggcggccgca    360

ctcggggatc atggcccaag ttgcaatgtc caccctcccc gttgaagatg aggagtcctc    420

ggagagcagg atggtggtga cattcctcat gtcagctctc gagtccatgt gtaaagaact    480

ggccaagtcc aaagccgaag tggcctgcat tgcagtgtat gaaacagacg tgtttgtcgt    540

cggaactgaa agaggacgtg cttttgtcaa taccagaaag gattttcaaa aagattttgt    600

aaaatattgt gttgaagaag aagaaaaagc tgcagagatg cataaaatga aatctacaac    660

ccaggcaaat cggatgagtg tagatgctgt agaaattgaa acactcagaa aaacagttga    720

ggactatttc tgcttttgct atgggaaagc tttaggcaaa tccacagtgg tacctgtacc    780

atatgagaag atgctgcgag accagtcggc tgtggtagtg caggggcttc cggaaggtgt    840

tgcctttaaa caccccgaga actatgatct tgcaaccctg aaatggattt tggagaacaa    900

agcagggatt tcattcatca ttaagagacc ttttttagag ccaaagaagc atgtaggtgg    960

tcgtgtgatg gtaacagatg ctgacaggtc aatactatct ccaggtggaa gttgtggccc   1020

catcaaagtg aaaactgaac ccacagaaga ttctggcatt tccctggaaa tggcagctgt   1080

gacagtaaag gaagaatcag aagatcctga ttattatcaa tataacattc aaggaagcca   1140

ccattcttca gagggcaatg aaggcacaga aatggaagta ccagcagaag atgatgatta   1200

ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag tcccggaacc   1260

cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga atgctcgcat   1320

cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc aagccataaa   1380

agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg aagatcttta   1440

tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg gaattcctcg   1500

cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga aacatgagct   1560

tctgaattca acacgtgaag atttacagct tgataaacca gcttcaggag taaaggaaga   1620

atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct gcaaaaaatt   1680

tgcggaacgc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat ttgaggcaca   1740

cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa gtccctcatg   1800

gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta aatttgttat   1860

taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa gaacgaatac   1920

accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag tggaagagat   1980

ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag taccatatcc   2040

tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg ggattccctt   2100

ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg ggagtaataa   2160

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2220

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2280

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2340

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2400

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2460

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2520

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2580

gccattccga agaccatcga cttttggcat tccgagactg gagaagatac tcagaaacaa   2640

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2700

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2760

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2820

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2880

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2940

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   3000

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   3060

cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg atcagagtga   3120

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   3180

agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag accccacgtg   3240

gtagacctct tccctcctag gcttaaagta tcagtggttg agaagagctt ttcggacctg   3300

ttactacccc aagctgtgta atataccttg gtataacaga aataccttct atacaaacct   3360

ttttttctac ttttagatag aaatgtctac tttttcagca gttctgtgaa ttaaagagca   3420

gagtgactgt gggtctggaa tggctggtgt acttgggaat gtactatcag gattttacag   3480

caatgctggg aaatgacagg gaaaatgaca ggaatgaatc tcaccagatt ttttatgtac   3540

tcagcagagc cttgagttac ggtgtttatt ttccaatcaa gtgaagatat ctcctacttc   3600

tcctactgga acatctcagc ttctgcagtg aagaaaaatt cctgtgatag ttcagttctt   3660

tagtttttct atttgaaaaa aaaaaaatca tttaaatgat cctttgttca cggctctcct   3720

taatgactga gtgaacagtt cctatctgta tatttgacta aaccttttcc taagctatct   3780

ctcatggttc ctatgttttt ttatcataat taaaagcaaa accatctgga tcacctaaca   3840

gtcagaggtc agtatctcag cgtgtgaatt atagaggaat acagagagaa cctctcccac   3900

tttttacttt tcgtccaaat aaaatgcatg gtgtaccaga agttgaagat cgggttgagg   3960

attggggcta gctcgatgac actaaggccc caacatcgcg ggacctgctg tggcgcggat   4020

tcttaggaac gctgttctag ccggccccct ctccaggggt cgccgtggcc ggcattattt   4080

cctagttctt cttgtaaccc tgaggtgcca gcgcggggag tgaggagggg tcagggggct   4140

aaggatgcaa cctctgacgt tctgcgcctt cctaggagag tcttacatgt gttgagattt   4200

cacaagcaat gcgagttgta aaataccagc tctacaagaa actaggctct gtgacggcat   4260

agttttcagt agctttatca caatattcac aatggagaat tatatgacat ggtagcagaa   4320

ataggccctt ttatgtgttg cttctatttt acctcaaatt gtagatatag ggtaatcaat   4380

aaaatccatc catgcctttc acacactaaa aaaaaaaaaa aa                      4422


<210>  466
<211>  957
<212>  PRT
<213>  Homo sapiens

<400>  466

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Arg Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
                565                 570                 575


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
            580                 585                 590


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
        595                 600                 605


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
    610                 615                 620


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
625                 630                 635                 640


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
                645                 650                 655


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
            660                 665                 670


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
        675                 680                 685


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
    690                 695                 700


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
705                 710                 715                 720


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
                725                 730                 735


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
            740                 745                 750


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
        755                 760                 765


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
    770                 775                 780


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
785                 790                 795                 800


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
                805                 810                 815


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
            820                 825                 830


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
        835                 840                 845


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
    850                 855                 860


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
865                 870                 875                 880


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
                885                 890                 895


Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu 
            900                 905                 910


Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu 
        915                 920                 925


Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp 
    930                 935                 940


Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950                 955


<210>  467
<211>  4537
<212>  DNA
<213>  Homo sapiens

<400>  467
aggaggagga gggtgagaga gaagctggga gagcagagaa aaggggccac cggtcgcccc     60

cccgcttccc cgcacgcgct ctccagccgc ggccgcccgc ctgccgcggt caccccggcc    120

tctgcctctg tcccccagtg atcggatcaa ggcgctgagc gaggccctgc ctgcggggcg    180

gccatgcggc ggtgacagga gcgcgaccga cacgcacggg cccctcgccc cctctcgcct    240

cccgtccgct cgccagctcc cctcagccga ggctgctccg cggcggccgc agcccgcgcg    300

cggcccacac tcgcctcccc tcggcacccc cggccccgga gctgcctgga ggcggccgca    360

ctcggggatc atggcccaag ttgcaatgtc caccctcccc gttgaagatg aggagtcctc    420

ggagagcagg atggtggtga cattcctcat gtcagctctc gagtccatgt gtaaagaact    480

ggccaagtcc aaagccgaag tggcctgcat tgcagtgtat gaaacagacg tgtttgtcgt    540

cggaactgaa agaggacgtg cttttgtcaa taccagaaag gattttcaaa aagattttgt    600

aaaatattgt gttgaagaag aagaaaaagc tgcagagatg cataaaatga aatctacaac    660

ccaggcaaat cggatgagtg tagatgctgt agaaattgaa acactcagaa aaacagttga    720

ggactatttc tgcttttgct atgggaaagc tttaggcaaa tccacagtgg tacctgtacc    780

atatgagaag atgctgcgag accagtcggc tgtggtagtg caggggcttc cggaaggtgt    840

tgcctttaaa caccccgaga actatgatct tgcaaccctg aaatggattt tggagaacaa    900

agcagggatt tcattcatca ttaagagacc ttttttagag ccaaagaagc atgtaggtgg    960

tcgtgtgatg gtaacagatg ctgacaggtc aatactatct ccaggtggaa gttgtggccc   1020

catcaaagtg aaaactgaac ccacagaaga ttctggcatt tccctggaaa tggcagctgt   1080

gacagtaaag gaagaatcag aagatcctga ttattatcaa tataacattc aagcaggccc   1140

ttctgaaact gatgatgttg atgaaaaaca gcccctatcg aagcctttgc aaggaagcca   1200

ccattcttca gagggcaatg aaggcacaga aatggaagta ccagcagaag attctactca   1260

acatgtccct tcagaaacaa gtgaggaccc tgaagttgag gtgactattg aagatgatga   1320

ttattctcca ccgtctaaga gaccaaaggc caatgagcta ccgcagccac cagtcccgga   1380

acccgccaat gctgggaagc ggaaagtgag ggagttcaac ttcgagaaat ggaatgctcg   1440

catcactgat ctacgtaaac aagttgaaga attgtttgaa aggaaatatg ctcaagccat   1500

aaaagccaaa ggtccggtga cgatcccgta ccctcttttc cagtctcatg ttgaagatct   1560

ttatgtagaa ggacttcctg aaggaattcc ttttagaagg ccatctactt acggaattcc   1620

tcgcctggag aggatattac ttgcaaagga aaggattcgt tttgtgatta agaaacatga   1680

gcttctgaat tcaacacgtg aagatttaca gcttgataag ccagcttcag gagtaaagga   1740

agaatggtat gccagaatca ctaaattaag aaagatggtg gatcagcttt tctgcaaaaa   1800

atttgcggaa gccttgggga gcactgaagc caaggctgta ccgtaccaaa aatttgaggc   1860

acacccgaat gatctgtacg tggaaggact gccagaaaac attcctttcc gaagtccctc   1920

atggtatgga atcccaaggc tggaaaaaat cattcaagtg ggcaatcgaa ttaaatttgt   1980

tattaaaaga ccagaacttc tgactcacag taccactgaa gttactcagc caagaacgaa   2040

tacaccagtc aaggaagatt ggaatgtcag aattaccaag ctacggaagc aagtggaaga   2100

gatttttaat ttgaaatttg ctcaagctct tggactcacc gaggcagtaa aagtaccata   2160

tcctgtgttt gaatcaaacc cggagttctt gtatgtggaa ggcttgccag aggggattcc   2220

cttccgaagc cctacctggt ttggaattcc acgacttgaa aggatcgtcc gcgggagtaa   2280

taaaatcaag ttcgttgtta aaaaacctga actagttatt tcctacttgc ctcctgggat   2340

ggctagtaaa ataaacacta aagctttgca gtcccccaaa agaccacgaa gtcctgggag   2400

taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc cctaataaca acaatcctca   2460

aacctcagct gttcgaaccc cgacccagac taacggttct aacgttccct tcaagccacg   2520

agggagagag ttttcctttg aggcctggaa tgccaaaatc acggacctaa aacagaaagt   2580

tgaaaatctc ttcaatgaga aatgtgggga agctcttggc cttaaacaag ctgtgaaggt   2640

gccgttcgcg ttatttgagt ctttcccgga agacttttat gtggaaggct tacctgaggg   2700

tgtgccattc cgaagaccat cgacttttgg cattccgagg ctggagaaga tactcagaaa   2760

caaagccaaa attaagttca tcattaaaaa gcccgaaatg tttgagacgg cgattaagga   2820

gagcacctcc tctaagagcc ctcccagaaa aataaattca tcacccaatg ttaatactac   2880

tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca attccagatg atgataatga   2940

aagactctcg aaagttgaaa aagctagaca gctaagagaa caagtgaatg acctctttag   3000

tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg aaagttccct acaggaaaat   3060

cacaattaac cctggctgtg tggtggttga tggcatgccc ccgggggtgt ccttcaaagc   3120

ccccagctac ctggaaatca gctccatgag aaggatctta gactctgccg agtttatcaa   3180

attcacggtc attagaccat ttccaggact tgtgattaat aaccagctgg ttgatcagag   3240

tgagtcagaa ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc   3300

cacagaagaa ataaaagaga ctgatggaag ctctcagatc aagcaagaac cagaccccac   3360

gtggtagacc tcttccctcc taggcttaaa gtatcagtgg ttgagaagag cttttcggac   3420

ctgttactac cccaagctgt gtaatatact tgtataacag aaataccttc tatacaaacc   3480

tttttttcta cttttagata gaaatgtcta ctttttcagc agttctgtga attaaagagc   3540

agagtgactg tgggtctgga atggctggtg tacttgggaa tgtactatca ggattttaca   3600

gcaatgctgg gaaatgacag ggaaaatgac aggaatgaat ctcaccagat tttttatgta   3660

ctcagcagag ccttgagtta cggtgtttat tttccaatca agtgaagata tctcctactt   3720

ctcctactgg aacatctcag cttctgcagt gaagaaaaat tcctgtgata gttcagttct   3780

ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat cctttgttca cggctctcct   3840

taatgactga gtgaacagtt cctatctgta tatttgacta aaccttttcc taagctatct   3900

ctcatggttc ctatgttttt ttatcataat taaaagcaaa accatctgga tcacctaaca   3960

gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa tacagagaga acctcttcca   4020

cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga agttgaagat cgggttgagg   4080

attggggcta gctcgatgac actaaggccc caacatcgcg ggacctgctg tggcgcggat   4140

tcttaggaac gctgttctag ccggccccct ctccaggggt cgcgtggccg gcattatttc   4200

ctagttcttc ttgtaaccct gaggtgccag cgcggggagt gaggaggggt cagggggcta   4260

aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg ttgagatttc   4320

acaagcaatg cgagttgtaa aataccagct ctacaagaag ctaggctctg tgacggcata   4380

gttttcagta gctttatcac aatattcaca atggagaatt atatgacatg gtagcagaaa   4440

taggcccttt tatgtgttgc ttctatttta cctcaaattg tagatatagg gtaatcaata   4500

aaatccatcc atgcctttca cacactaaaa agtcgga                            4537


<210>  468
<211>  998
<212>  PRT
<213>  Homo sapiens

<400>  468

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr 
        595                 600                 605


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe 
    610                 615                 620


Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys 
625                 630                 635                 640


Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly 
                645                 650                 655


Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro 
            660                 665                 670


Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val 
        675                 680                 685


Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro 
    690                 695                 700


Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu 
705                 710                 715                 720


Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys 
                725                 730                 735


Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys 
            740                 745                 750


Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp 
        755                 760                 765


Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser 
    770                 775                 780


Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys 
785                 790                 795                 800


Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys 
                805                 810                 815


Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro 
            820                 825                 830


Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln 
        835                 840                 845


Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys 
    850                 855                 860


Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe 
865                 870                 875                 880


Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys 
                885                 890                 895


Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly 
            900                 905                 910


Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg 
        915                 920                 925


Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe 
    930                 935                 940


Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu 
945                 950                 955                 960


Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro 
                965                 970                 975


Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln 
            980                 985                 990


Glu Pro Asp Pro Thr Trp 
        995


<210>  469
<211>  4477
<212>  DNA
<213>  Homo sapiens

<400>  469
aggaggagga gggtgagaga gaagctggga gagcagagaa aaggggccac cggtcgcccc     60

cccgcttccc cgcacgcgct ctccagccgc ggccgcccgc ctgccgcggt caccccggcc    120

tctgcctctg tcccccagtg atcggatcaa ggcgctgagc gaggccctgc ctgcggggcg    180

gccatgcggc ggtgacagga gcgcgaccga cacgcacggg cccctcgccc cctctcgcct    240

cccgtccgct cgccagctcc cctcagccga ggctgctccg cggcggccgc agcccgcgcg    300

cggcccacac tcgcctcccc tcggcacccc cggccccgga gctgcctgga ggcggccgca    360

ctcggggatc atggcccaag ttgcaatgtc caccctcccc gttgaagatg aggagtcctc    420

ggagagcagg atggtggtga cattcctcat gtcagctctc gagtccatgt gtaaagaact    480

ggccaagtcc aaagccgaag tggcctgcat tgcagtgtat gaaacagacg tgtttgtcgt    540

cggaactgaa agaggacgtg cttttgtcaa taccagaaag gattttcaaa aagattttgt    600

aaaatattgt gttgaagaag aagaaaaagc tgcagagatg cataaaatga aatctacaac    660

ccaggcaaat cggatgagtg tagatgctgt agaaattgaa acactcagaa aaacagttga    720

ggactatttc tgcttttgct atgggaaagc tttaggcaaa tccacagtgg tacctgtacc    780

atatgagaag atgctgcgag accagtcggc tgtggtagtg caggggcttc cggaaggtgt    840

tgcctttaaa caccccgaga actatgatct tgcaaccctg aaatggattt tggagaacaa    900

agcagggatt tcattcatca ttaagagacc ttttttagag ccaaagaagc atgtaggtgg    960

tcgtgtgatg gtaacagatg ctgacaggtc aatactatct ccaggtggaa gttgtggccc   1020

catcaaagtg aaaactgaac ccacagaaga ttctggcatt tccctggaaa tggcagctgt   1080

gacagtaaag gaagaatcag aagatcctga ttattatcaa tataacattc aaggaagcca   1140

ccattcttca gagggcaatg aaggcacaga aatggaagta ccagcagaag attctactca   1200

acatgtccct tcagaaacaa gtgaggaccc tgaagttgag gtgactattg aagatgatga   1260

ttattctcca ccgtctaaga gaccaaaggc caatgagcta ccgcagccac cagtcccgga   1320

acccgccaat gctgggaagc ggaaagtgag ggagttcaac ttcgagaaat ggaatgctcg   1380

catcactgat ctacgtaaac aagttgaaga attgtttgaa aggaaatatg ctcaagccat   1440

aaaagccaaa ggtccggtga cgatcccgta ccctcttttc cagtctcatg ttgaagatct   1500

ttatgtagaa ggacttcctg aaggaattcc ttttagaagg ccatctactt acggaattcc   1560

tcgcctggag aggatattac ttgcaaagga aaggattcgt tttgtgatta agaaacatga   1620

gcttctgaat tcaacacgtg aagatttaca gcttgataag ccagcttcag gagtaaagga   1680

agaatggtat gccagaatca ctaaattaag aaagatggtg gatcagcttt tctgcaaaaa   1740

atttgcggaa gccttgggga gcactgaagc caaggctgta ccgtaccaaa aatttgaggc   1800

acacccgaat gatctgtacg tggaaggact gccagaaaac attcctttcc gaagtccctc   1860

atggtatgga atcccaaggc tggaaaaaat cattcaagtg ggcaatcgaa ttaaatttgt   1920

tattaaaaga ccagaacttc tgactcacag taccactgaa gttactcagc caagaacgaa   1980

tacaccagtc aaggaagatt ggaatgtcag aattaccaag ctacggaagc aagtggaaga   2040

gatttttaat ttgaaatttg ctcaagctct tggactcacc gaggcagtaa aagtaccata   2100

tcctgtgttt gaatcaaacc cggagttctt gtatgtggaa ggcttgccag aggggattcc   2160

cttccgaagc cctacctggt ttggaattcc acgacttgaa aggatcgtcc gcgggagtaa   2220

taaaatcaag ttcgttgtta aaaaacctga actagttatt tcctacttgc ctcctgggat   2280

ggctagtaaa ataaacacta aagctttgca gtcccccaaa agaccacgaa gtcctgggag   2340

taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc cctaataaca acaatcctca   2400

aacctcagct gttcgaaccc cgacccagac taacggttct aacgttccct tcaagccacg   2460

agggagagag ttttcctttg aggcctggaa tgccaaaatc acggacctaa aacagaaagt   2520

tgaaaatctc ttcaatgaga aatgtgggga agctcttggc cttaaacaag ctgtgaaggt   2580

gccgttcgcg ttatttgagt ctttcccgga agacttttat gtggaaggct tacctgaggg   2640

tgtgccattc cgaagaccat cgacttttgg cattccgagg ctggagaaga tactcagaaa   2700

caaagccaaa attaagttca tcattaaaaa gcccgaaatg tttgagacgg cgattaagga   2760

gagcacctcc tctaagagcc ctcccagaaa aataaattca tcacccaatg ttaatactac   2820

tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca attccagatg atgataatga   2880

aagactctcg aaagttgaaa aagctagaca gctaagagaa caagtgaatg acctctttag   2940

tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg aaagttccct acaggaaaat   3000

cacaattaac cctggctgtg tggtggttga tggcatgccc ccgggggtgt ccttcaaagc   3060

ccccagctac ctggaaatca gctccatgag aaggatctta gactctgccg agtttatcaa   3120

attcacggtc attagaccat ttccaggact tgtgattaat aaccagctgg ttgatcagag   3180

tgagtcagaa ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc   3240

cacagaagaa ataaaagaga ctgatggaag ctctcagatc aagcaagaac cagaccccac   3300

gtggtagacc tcttccctcc taggcttaaa gtatcagtgg ttgagaagag cttttcggac   3360

ctgttactac cccaagctgt gtaatatact tgtataacag aaataccttc tatacaaacc   3420

tttttttcta cttttagata gaaatgtcta ctttttcagc agttctgtga attaaagagc   3480

agagtgactg tgggtctgga atggctggtg tacttgggaa tgtactatca ggattttaca   3540

gcaatgctgg gaaatgacag ggaaaatgac aggaatgaat ctcaccagat tttttatgta   3600

ctcagcagag ccttgagtta cggtgtttat tttccaatca agtgaagata tctcctactt   3660

ctcctactgg aacatctcag cttctgcagt gaagaaaaat tcctgtgata gttcagttct   3720

ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat cctttgttca cggctctcct   3780

taatgactga gtgaacagtt cctatctgta tatttgacta aaccttttcc taagctatct   3840

ctcatggttc ctatgttttt ttatcataat taaaagcaaa accatctgga tcacctaaca   3900

gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa tacagagaga acctcttcca   3960

cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga agttgaagat cgggttgagg   4020

attggggcta gctcgatgac actaaggccc caacatcgcg ggacctgctg tggcgcggat   4080

tcttaggaac gctgttctag ccggccccct ctccaggggt cgcgtggccg gcattatttc   4140

ctagttcttc ttgtaaccct gaggtgccag cgcggggagt gaggaggggt cagggggcta   4200

aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg ttgagatttc   4260

acaagcaatg cgagttgtaa aataccagct ctacaagaag ctaggctctg tgacggcata   4320

gttttcagta gctttatcac aatattcaca atggagaatt atatgacatg gtagcagaaa   4380

taggcccttt tatgtgttgc ttctatttta cctcaaattg tagatatagg gtaatcaata   4440

aaatccatcc atgcctttca cacactaaaa agtcgga                            4477


<210>  470
<211>  978
<212>  PRT
<213>  Homo sapiens

<400>  470

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu 
            580                 585                 590


Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg 
        595                 600                 605


Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys 
    610                 615                 620


Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys 
625                 630                 635                 640


Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly 
                645                 650                 655


Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn 
            660                 665                 670


Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn 
        675                 680                 685


Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu 
    690                 695                 700


Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu 
705                 710                 715                 720


Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys 
                725                 730                 735


Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu 
            740                 745                 750


Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile 
        755                 760                 765


Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile 
    770                 775                 780


Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser 
785                 790                 795                 800


Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr 
                805                 810                 815


Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro 
            820                 825                 830


Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu 
        835                 840                 845


Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile 
    850                 855                 860


Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn 
865                 870                 875                 880


Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys 
                885                 890                 895


Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser 
            900                 905                 910


Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val 
        915                 920                 925


Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile 
    930                 935                 940


Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu 
945                 950                 955                 960


Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro 
                965                 970                 975


Thr Trp 



<210>  471
<211>  4474
<212>  DNA
<213>  Homo sapiens

<400>  471
aggaggagga gggtgagaga gaagctggga gagcagagaa aaggggccac cggtcgcccc     60

cccgcttccc cgcacgcgct ctccagccgc ggccgcccgc ctgccgcggt caccccggcc    120

tctgcctctg tcccccagtg atcggatcaa ggcgctgagc gaggccctgc ctgcggggcg    180

gccatgcggc ggtgacagga gcgcgaccga cacgcacggg cccctcgccc cctctcgcct    240

cccgtccgct cgccagctcc cctcagccga ggctgctccg cggcggccgc agcccgcgcg    300

cggcccacac tcgcctcccc tcggcacccc cggccccgga gctgcctgga ggcggccgca    360

ctcggggatc atggcccaag ttgcaatgtc caccctcccc gttgaagatg aggagtcctc    420

ggagagcagg atggtggtga cattcctcat gtcagctctc gagtccatgt gtaaagaact    480

ggccaagtcc aaagccgaag tggcctgcat tgcagtgtat gaaacagacg tgtttgtcgt    540

cggaactgaa agaggacgtg cttttgtcaa taccagaaag gattttcaaa aagattttgt    600

aaaatattgt gttgaagaag aagaaaaagc tgcagagatg cataaaatga aatctacaac    660

ccaggcaaat cggatgagtg tagatgctgt agaaattgaa acactcagaa aaacagttga    720

ggactatttc tgcttttgct atgggaaagc tttaggcaaa tccacagtgg tacctgtacc    780

atatgagaag atgctgcgag accagtcggc tgtggtagtg caggggcttc cggaaggtgt    840

tgcctttaaa caccccgaga actatgatct tgcaaccctg aaatggattt tggagaacaa    900

agcagggatt tcattcatca ttaagagacc ttttttagag ccaaagaagc atgtaggtgg    960

tcgtgtgatg gtaacagatg ctgacaggtc aatactatct ccaggtggaa gttgtggccc   1020

catcaaagtg aaaactgaac ccacagaaga ttctggcatt tccctggaaa tggcagctgt   1080

gacagtaaag gaagaatcag aagatcctga ttattatcaa tataacattc aagcaggccc   1140

ttctgaaact gatgatgttg atgaaaaaca gcccctatcg aagcctttgc aaggaagcca   1200

ccattcttca gagggcaatg aaggcacaga aatggaagta ccagcagaag atgatgatta   1260

ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag tcccggaacc   1320

cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga atgctcgcat   1380

cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc aagccataaa   1440

agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg aagatcttta   1500

tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg gaattcctcg   1560

cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga aacatgagct   1620

tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag taaaggaaga   1680

atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct gcaaaaaatt   1740

tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat ttgaggcaca   1800

cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa gtccctcatg   1860

gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta aatttgttat   1920

taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa gaacgaatac   1980

accagtcaag gaagattgga atgtcagaat taccaagcta cggaagcaag tggaagagat   2040

ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag taccatatcc   2100

tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg ggattccctt   2160

ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg ggagtaataa   2220

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2280

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2340

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2400

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2460

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2520

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2580

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2640

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2700

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2760

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2820

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2880

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2940

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   3000

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   3060

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   3120

cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg atcagagtga   3180

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   3240

agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag accccacgtg   3300

gtagacctct tccctcctag gcttaaagta tcagtggttg agaagagctt ttcggacctg   3360

ttactacccc aagctgtgta atatacttgt ataacagaaa taccttctat acaaaccttt   3420

ttttctactt ttagatagaa atgtctactt tttcagcagt tctgtgaatt aaagagcaga   3480

gtgactgtgg gtctggaatg gctggtgtac ttgggaatgt actatcagga ttttacagca   3540

atgctgggaa atgacaggga aaatgacagg aatgaatctc accagatttt ttatgtactc   3600

agcagagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct cctacttctc   3660

ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta   3720

gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg ctctccttaa   3780

tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa gctatctctc   3840

atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca cctaacagtc   3900

agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc tcttccactt   3960

ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg gttgaggatt   4020

ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg cgcggattct   4080

taggaacgct gttctagccg gccccctctc caggggtcgc gtggccggca ttatttccta   4140

gttcttcttg taaccctgag gtgccagcgc ggggagtgag gaggggtcag ggggctaagg   4200

atgcaacctc tgacgttctg cgccttccta ggagagtctt acatgtgttg agatttcaca   4260

agcaatgcga gttgtaaaat accagctcta caagaagcta ggctctgtga cggcatagtt   4320

ttcagtagct ttatcacaat attcacaatg gagaattata tgacatggta gcagaaatag   4380

gcccttttat gtgttgcttc tattttacct caaattgtag atatagggta atcaataaaa   4440

tccatccatg cctttcacac actaaaaagt cgga                               4474


<210>  472
<211>  977
<212>  PRT
<213>  Homo sapiens

<400>  472

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
                565                 570                 575


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
            580                 585                 590


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
        595                 600                 605


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
    610                 615                 620


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
625                 630                 635                 640


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
                645                 650                 655


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
            660                 665                 670


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
        675                 680                 685


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
    690                 695                 700


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
705                 710                 715                 720


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
                725                 730                 735


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
            740                 745                 750


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
        755                 760                 765


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
    770                 775                 780


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
785                 790                 795                 800


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
                805                 810                 815


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
            820                 825                 830


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
        835                 840                 845


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
    850                 855                 860


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
865                 870                 875                 880


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
                885                 890                 895


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
            900                 905                 910


Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile 
        915                 920                 925


Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln 
    930                 935                 940


Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile 
945                 950                 955                 960


Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr 
                965                 970                 975


Trp 



<210>  473
<211>  1062
<212>  DNA
<213>  Homo sapiens

<400>  473
atggaggggg cacggaagac actcaaatgt aagcagcatt gctaccaccg gcaaggcacg     60

aggacgatgc caaactggag ggggaagtgg agggagaaag acataggagg aaaaggcttc    120

ttgtccctgc ccctacgagc tcaacaccca aacaggcccc gcggggcagg cgcgccgggc    180

cggcccggga caaagcccac tgcggactcc acctgggagc ggggcggggc gggggacagc    240

gctcccgctc ccccgcccgc cgcagttacc aggcaacgcg cggccccgcc cccgcgccgg    300

ttggccaatc ccgcgcgtct gctgccccgg cgcaggagcc ccagatacac caggcgagcg    360

cgaccccacg acggctcggg cctggcaccg cgcgcgcccc cgcaccgcct agccggccaa    420

tcagcgcggc ggggcatgcg cagcccgcag ggccgctcgc tcgctcgcgc gcgggatcgc    480

acgcgcgagg cgccccccca ccgcacgccg gtcggcgcgc gcgcccctcc cccacgcgca    540

ctgaggcgcg cgcgtgccac tgtcgtcccc cgcgaccgcg tccgtgccgc cccaccccca    600

tcgcctcgtt tcggccactg ccaaggccgg cggggctcga gacccggcga ggcggtgggg    660

gtgggggtag ggggaggcgg cacgggcgcc ccccaaggcc ccacaccgcg cgcggcgggc    720

cgcggctccc aggcccctgt ccctgcaggc cccggcgggg caaagtctct aataaaggcc    780

cccgctcgca atggcccccg aggcgggggc ggggggcgcg gggatgaggc gagagggact    840

cacccgagtg cggccgcctc caggcagctc cggggccggg ggtgccgagg ggaggcgagt    900

gtgggccgcg cgcgggctgc ggccgccgcg gagcagcctc ggctgagggg agctggcgag    960

cggacgggag gcgagagggg gcgaggggcc cgtgcgtgtc ggtcgcgctc ctgtcaccgc   1020

cgcatggccg ccccgcaggc agggcctcgc tcagcgcctt ga                      1062


<210>  474
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  474

Met Glu Gly Ala Arg Lys Thr Leu Lys Cys Lys Gln His Cys Tyr His 
1               5                   10                  15


Arg Gln Gly Thr Arg Thr Met Pro Asn Trp Arg Gly Lys Trp Arg Glu 
            20                  25                  30


Lys Asp Ile Gly Gly Lys Gly Phe Leu Ser Leu Pro Leu Arg Ala Gln 
        35                  40                  45


His Pro Asn Arg Pro Arg Gly Ala Gly Ala Pro Gly Arg Pro Gly Thr 
    50                  55                  60


Lys Pro Thr Ala Asp Ser Thr Trp Glu Arg Gly Gly Ala Gly Asp Ser 
65                  70                  75                  80


Ala Pro Ala Pro Pro Pro Ala Ala Val Thr Arg Gln Arg Ala Ala Pro 
                85                  90                  95


Pro Pro Arg Arg Leu Ala Asn Pro Ala Arg Leu Leu Pro Arg Arg Arg 
            100                 105                 110


Ser Pro Arg Tyr Thr Arg Arg Ala Arg Pro His Asp Gly Ser Gly Leu 
        115                 120                 125


Ala Pro Arg Ala Pro Pro His Arg Leu Ala Gly Gln Ser Ala Arg Arg 
    130                 135                 140


Gly Met Arg Ser Pro Gln Gly Arg Ser Leu Ala Arg Ala Arg Asp Arg 
145                 150                 155                 160


Thr Arg Glu Ala Pro Pro His Arg Thr Pro Val Gly Ala Arg Ala Pro 
                165                 170                 175


Pro Pro Arg Ala Leu Arg Arg Ala Arg Ala Thr Val Val Pro Arg Asp 
            180                 185                 190


Arg Val Arg Ala Ala Pro Pro Pro Ser Pro Arg Phe Gly His Cys Gln 
        195                 200                 205


Gly Arg Arg Gly Ser Arg Pro Gly Glu Ala Val Gly Val Gly Val Gly 
    210                 215                 220


Gly Gly Gly Thr Gly Ala Pro Gln Gly Pro Thr Pro Arg Ala Ala Gly 
225                 230                 235                 240


Arg Gly Ser Gln Ala Pro Val Pro Ala Gly Pro Gly Gly Ala Lys Ser 
                245                 250                 255


Leu Ile Lys Ala Pro Ala Arg Asn Gly Pro Arg Gly Gly Gly Gly Gly 
            260                 265                 270


Arg Gly Asp Glu Ala Arg Gly Thr His Pro Ser Ala Ala Ala Ser Arg 
        275                 280                 285


Gln Leu Arg Gly Arg Gly Cys Arg Gly Glu Ala Ser Val Gly Arg Ala 
    290                 295                 300


Arg Ala Ala Ala Ala Ala Glu Gln Pro Arg Leu Arg Gly Ala Gly Glu 
305                 310                 315                 320


Arg Thr Gly Gly Glu Arg Gly Arg Gly Ala Arg Ala Cys Arg Ser Arg 
                325                 330                 335


Ser Cys His Arg Arg Met Ala Ala Pro Gln Ala Gly Pro Arg Ser Ala 
            340                 345                 350


Pro 



<210>  475
<211>  3161
<212>  DNA
<213>  Homo sapiens

<400>  475
agcgaccgca gccgggggga cgcgggagga tggagcaagt ggagatcctg aggaaattca     60

tccagagggt ccaggccatg aagagtcctg accacaatgg ggaggacaac ttcgcccggg    120

acttcatgcg gttaagaaga ttgtctacca aatatagaac agaaaagata tatcccacag    180

ccactggaga aaaagaagaa aatgttaaaa agaacagata caaggacata ctgccatttg    240

atcacagccg agttaaattg acattaaaga ctccttcaca agattcagac tatatcaatg    300

caaattttat aaagggcgtc tatgggccaa aagcatatgt agcaactcaa ggacctttag    360

caaatacagt aatagatttt tggaggatga tatgggagta taatgttgtg atcattgtaa    420

tggcctgccg agaatttgag atgggaagga aaaaatgtga gcgctattgg cctttgtatg    480

gagaagaccc cataacgttt gcaccattta aaatttcttg tgaggatgaa caagcaagaa    540

cagactactt catcaggaca ctcttacttg aatttcaaaa tgaatctcgt aggctgtatc    600

agtttcatta tgtgaactgg ccagaccatg atgttccttc atcatttgat tctattctgg    660

acatgataag cttaatgagg aaatatcaag aacatgaaga tgttcctatt tgtattcatt    720

gcagtgcagg ctgtggaaga acaggtgcca tttgtgccat agattatacg tggaatttac    780

taaaagctgg gaaaatacca gaggaattta atgtatttaa tttaatacaa gaaatgagaa    840

cacaaaggca ttctgcagta caaacaaagg agcaatatga acttgttcat agagctattg    900

cccaactgtt tgaaaaacag ctacaactat atgaaattca tggagctcag aaaattgctg    960

atggagtgaa tgaaattaac actgaaaaca tgatcagctc catagagcct gaaaaacaag   1020

attctcctcc tccaaaacca ccaaggaccc gcagttgcct tgttgaaggg gatgctaaag   1080

aagaaatact gcagccaccg gaacctcatc cagtgccacc catcttgaca ccttctcccc   1140

cttcagcttt tccaacagtc actactgtgt ggcaggacaa tgatagatac catccaaagc   1200

cagtgttgca tatggtttca tcagaacaac attcagcaga cctcaacaga aactatagta   1260

aatcaacaga acttccaggg aaaaatgaat caacaattga acagatagat aaaaaattgg   1320

aacgaaattt aagttttgag attaagaagg tccctctcca agagggacca aaaagttttg   1380

atgggaacac acttttgaat aggggacatg caattaaaat taaatctgct tcaccttgta   1440

tagctgataa aatctctaag ccacaggaat taagttcaga tctaaatgtc ggtgatactt   1500

cccagaattc ttgtgtggac tgcagtgtaa cacaatcaaa caaagtttca gttactccac   1560

cagaagaatc ccagaattca gacacacctc caaggccaga ccgcttgcct cttgatgaga   1620

aaggacatgt aacgtggtca tttcatggac ctgaaaatgc catacccata cctgatttat   1680

ctgaaggcaa ttcctcagat atcaactatc aaactaggaa aactgtgagt ttaacaccaa   1740

gtcctacaac acaagttgaa acacctgatc ttgtggatca tgataacact tcaccactct   1800

tcagaacacc cctcagtttt actaatccac ttcactctga tgactcagac tcagatgaaa   1860

gaaactctga tggtgctgtg acccagaata aaactaatat ttcaacagca agtgccacag   1920

tttctgctgc cactagtact gaaagcattt ctactaggaa agtattgcca atgtccattg   1980

ctagacataa tatagcagga acaacacatt caggtgctga aaaagatgtt gatgttagtg   2040

aagattcacc tcctccccta cctgaaagaa ctcctgaatc gtttgtgtta gcaagtgaac   2100

ataatacacc tgtaagatcg gaatggagtg aacttcaaag tcaggaacga tctgaacaaa   2160

aaaagtctga aggcttgata acctctgaaa atgagaaatg tgatcatcca gcgggaggta   2220

ttcactatga aatgtgcata gaatgtccac ctactttcag tgacaagaga gaacaaatat   2280

cagaaaatcc aacagaagcc acagatattg gttttggtaa tcgatgtgga aaacccaaag   2340

gaccaagaga tccaccttca gaatggacat gattcaggga gctagaagac actttaagtt   2400

atactggaaa attcaggtgc cactgaaagc cagatttata gtattccatc tttaatatgt   2460

gggactaaca gcagtgtaga ttgttacctt aatatttttt gctgggacca tctacctgcc   2520

ttatactaca cttaggaaaa agtattacat atggtttatt ttgaaacttc aagtattatt   2580

gccttaatgt ctcttaaccc tgttacacgc tgcttgtaga catgttaata tagtaatacc   2640

tttatgatat attgagttta aggactactc tttttctgtt ttatcatgta tgcattattt   2700

tgtatatgta cagggcaagt aggtatataa tttgataaag ttgcaattga aatattatta   2760

acagaagatg taagaaattt ctgcatggtc taaatctttg tgtactttat ttgtaaatta   2820

tttgccctgg agttttagaa aatagtttct gaattttaaa cttgctggat tcatgcagcc   2880

agctttgcag gttatcagag atcaaagatt gtaataataa ttttgtaaat tgtaagcaaa   2940

aagttatttt tatattatat acagtctaat tgttcatcct aattgttcct gttttcatct   3000

agtcagagat tcagtaagtg ccttggaaca atattgaatt ctcttagctt gtgtgtgttt   3060

ctttaatatt tgaactcaag tgggattaga agactatcaa aatacatgta tgtttcagga   3120

tatttgacct gtcattaaaa aaaacaaaca gttttacagt g                       3161


<210>  476
<211>  780
<212>  PRT
<213>  Homo sapiens

<400>  476

Met Glu Gln Val Glu Ile Leu Arg Lys Phe Ile Gln Arg Val Gln Ala 
1               5                   10                  15


Met Lys Ser Pro Asp His Asn Gly Glu Asp Asn Phe Ala Arg Asp Phe 
            20                  25                  30


Met Arg Leu Arg Arg Leu Ser Thr Lys Tyr Arg Thr Glu Lys Ile Tyr 
        35                  40                  45


Pro Thr Ala Thr Gly Glu Lys Glu Glu Asn Val Lys Lys Asn Arg Tyr 
    50                  55                  60


Lys Asp Ile Leu Pro Phe Asp His Ser Arg Val Lys Leu Thr Leu Lys 
65                  70                  75                  80


Thr Pro Ser Gln Asp Ser Asp Tyr Ile Asn Ala Asn Phe Ile Lys Gly 
                85                  90                  95


Val Tyr Gly Pro Lys Ala Tyr Val Ala Thr Gln Gly Pro Leu Ala Asn 
            100                 105                 110


Thr Val Ile Asp Phe Trp Arg Met Ile Trp Glu Tyr Asn Val Val Ile 
        115                 120                 125


Ile Val Met Ala Cys Arg Glu Phe Glu Met Gly Arg Lys Lys Cys Glu 
    130                 135                 140


Arg Tyr Trp Pro Leu Tyr Gly Glu Asp Pro Ile Thr Phe Ala Pro Phe 
145                 150                 155                 160


Lys Ile Ser Cys Glu Asp Glu Gln Ala Arg Thr Asp Tyr Phe Ile Arg 
                165                 170                 175


Thr Leu Leu Leu Glu Phe Gln Asn Glu Ser Arg Arg Leu Tyr Gln Phe 
            180                 185                 190


His Tyr Val Asn Trp Pro Asp His Asp Val Pro Ser Ser Phe Asp Ser 
        195                 200                 205


Ile Leu Asp Met Ile Ser Leu Met Arg Lys Tyr Gln Glu His Glu Asp 
    210                 215                 220


Val Pro Ile Cys Ile His Cys Ser Ala Gly Cys Gly Arg Thr Gly Ala 
225                 230                 235                 240


Ile Cys Ala Ile Asp Tyr Thr Trp Asn Leu Leu Lys Ala Gly Lys Ile 
                245                 250                 255


Pro Glu Glu Phe Asn Val Phe Asn Leu Ile Gln Glu Met Arg Thr Gln 
            260                 265                 270


Arg His Ser Ala Val Gln Thr Lys Glu Gln Tyr Glu Leu Val His Arg 
        275                 280                 285


Ala Ile Ala Gln Leu Phe Glu Lys Gln Leu Gln Leu Tyr Glu Ile His 
    290                 295                 300


Gly Ala Gln Lys Ile Ala Asp Gly Val Asn Glu Ile Asn Thr Glu Asn 
305                 310                 315                 320


Met Ile Ser Ser Ile Glu Pro Glu Lys Gln Asp Ser Pro Pro Pro Lys 
                325                 330                 335


Pro Pro Arg Thr Arg Ser Cys Leu Val Glu Gly Asp Ala Lys Glu Glu 
            340                 345                 350


Ile Leu Gln Pro Pro Glu Pro His Pro Val Pro Pro Ile Leu Thr Pro 
        355                 360                 365


Ser Pro Pro Ser Ala Phe Pro Thr Val Thr Thr Val Trp Gln Asp Asn 
    370                 375                 380


Asp Arg Tyr His Pro Lys Pro Val Leu His Met Val Ser Ser Glu Gln 
385                 390                 395                 400


His Ser Ala Asp Leu Asn Arg Asn Tyr Ser Lys Ser Thr Glu Leu Pro 
                405                 410                 415


Gly Lys Asn Glu Ser Thr Ile Glu Gln Ile Asp Lys Lys Leu Glu Arg 
            420                 425                 430


Asn Leu Ser Phe Glu Ile Lys Lys Val Pro Leu Gln Glu Gly Pro Lys 
        435                 440                 445


Ser Phe Asp Gly Asn Thr Leu Leu Asn Arg Gly His Ala Ile Lys Ile 
    450                 455                 460


Lys Ser Ala Ser Pro Cys Ile Ala Asp Lys Ile Ser Lys Pro Gln Glu 
465                 470                 475                 480


Leu Ser Ser Asp Leu Asn Val Gly Asp Thr Ser Gln Asn Ser Cys Val 
                485                 490                 495


Asp Cys Ser Val Thr Gln Ser Asn Lys Val Ser Val Thr Pro Pro Glu 
            500                 505                 510


Glu Ser Gln Asn Ser Asp Thr Pro Pro Arg Pro Asp Arg Leu Pro Leu 
        515                 520                 525


Asp Glu Lys Gly His Val Thr Trp Ser Phe His Gly Pro Glu Asn Ala 
    530                 535                 540


Ile Pro Ile Pro Asp Leu Ser Glu Gly Asn Ser Ser Asp Ile Asn Tyr 
545                 550                 555                 560


Gln Thr Arg Lys Thr Val Ser Leu Thr Pro Ser Pro Thr Thr Gln Val 
                565                 570                 575


Glu Thr Pro Asp Leu Val Asp His Asp Asn Thr Ser Pro Leu Phe Arg 
            580                 585                 590


Thr Pro Leu Ser Phe Thr Asn Pro Leu His Ser Asp Asp Ser Asp Ser 
        595                 600                 605


Asp Glu Arg Asn Ser Asp Gly Ala Val Thr Gln Asn Lys Thr Asn Ile 
    610                 615                 620


Ser Thr Ala Ser Ala Thr Val Ser Ala Ala Thr Ser Thr Glu Ser Ile 
625                 630                 635                 640


Ser Thr Arg Lys Val Leu Pro Met Ser Ile Ala Arg His Asn Ile Ala 
                645                 650                 655


Gly Thr Thr His Ser Gly Ala Glu Lys Asp Val Asp Val Ser Glu Asp 
            660                 665                 670


Ser Pro Pro Pro Leu Pro Glu Arg Thr Pro Glu Ser Phe Val Leu Ala 
        675                 680                 685


Ser Glu His Asn Thr Pro Val Arg Ser Glu Trp Ser Glu Leu Gln Ser 
    690                 695                 700


Gln Glu Arg Ser Glu Gln Lys Lys Ser Glu Gly Leu Ile Thr Ser Glu 
705                 710                 715                 720


Asn Glu Lys Cys Asp His Pro Ala Gly Gly Ile His Tyr Glu Met Cys 
                725                 730                 735


Ile Glu Cys Pro Pro Thr Phe Ser Asp Lys Arg Glu Gln Ile Ser Glu 
            740                 745                 750


Asn Pro Thr Glu Ala Thr Asp Ile Gly Phe Gly Asn Arg Cys Gly Lys 
        755                 760                 765


Pro Lys Gly Pro Arg Asp Pro Pro Ser Glu Trp Thr 
    770                 775                 780


<210>  477
<211>  3220
<212>  DNA
<213>  Homo sapiens

<400>  477
ccgcgccggc tagcggagga gagtaaatac aacaggagcg caaaatggcg gaaccgccga     60

gccccgtgca ctgtgtcgct gccgcggccc ccaccgccac cgtctcggag aaagaaccgt    120

ttggcaagct gcaactctcc tcccgggacc ctccgggttc tctgtccgcc aagaaggtcc    180

ggactgagga gaagaaggca ccgcggagag tgaacggaga agggggcagc ggcgggaaca    240

gcaggcagct gcagccgccg gcagcacctt cgcctcagag ctatggcagc cccgcgtctt    300

ggagctttgc ccctctgtct gctgctccct ccccgtcctc ttctcggagc agtttctctt    360

tctccgctgg cacggccgtt ccctcctcag cctccgcttc cttgtctcag ccggtgccgc    420

gcaaactgct ggtccctcct acgctgctgc acgctcagcc tcaccatctc ctcctgcccg    480

ccgccgccgc cgctgcctcg gctaacgcca agtcgcgcag acctaaggag aagcgggaga    540

aggagaggag gaggcacggt ctcggtgggg cccgagaggc cggcggggcc tcccgggagg    600

agaacgggga ggtgaagccg ctgccccgag ataaaatcaa agacaaaatt aaagagagag    660

acaaagaaaa agaaagagaa aaaaagaaac ataaagtaat gaatgagatc aagaaagaga    720

atggagaagt aaagattttg ctgaaaagtg ggaaggagaa accaaaaaca aatatagaag    780

acttacaaat taaaaaggta aagaagaaaa agaaaaagaa acacaaagag aatgaaaaac    840

ggaagcgtcc gaaaatgtat agcaaatcta ttcagaccat ctgctcagga ttgctaactg    900

atgttgaaga tcaagcagcc aaaggcatcc taaatgataa cataaaagat tacgttggga    960

agaatttgga taccaagaac tatgattcca aaattccaga gaacagtgag tttccatttg   1020

tctcattaaa ggagccacga gttcagaata acctcaaaag gttggacact ttggaattta   1080

aacaactcat tcatatagag caccagccta atggaggtgc atcggttatc catgcctaca   1140

gtaacgaact ctcccacctg tctcctatgg agatggagag gtttgcagaa gagtttgtgg   1200

gtctagtgtt cagtgaaaat gaaaactctg cagctttcta cgtgatgggt attgttcatg   1260

gggcagctac ttatttacct gactttttag actatttttc atttaatttt cccaattcac   1320

cagtgaaaat ggagatattg ggaaagaaag atatagagac aacgactatg tccaattttc   1380

atgctcaggt aaaaagaacg tattctcatg gtacttacag agctggccca atgagacaaa   1440

taagcttggt gggagcagtt gatgaagaag taggagatta tttccctgag ttccttgaca   1500

tgttggaaga gtcaccattt ttaaaatgta cactgccatg ggggacgcta tctagtctaa   1560

aattacagag tcgaaaagat agtgatgatg gtcccatcat gtgggttcgt ccaggagaac   1620

aaatgatccc tgtggctgat atgccaaagt cacctttcaa aaggaaaaga actaccaatg   1680

aaataaaaaa tcttcagtac ctacctcgaa caagtgagcc ccgtgagatg ctctttgaag   1740

acaggacaag agctcatgca gatcatatag gacaaggttt tgaacgacag actacagctg   1800

ctgttggagt gctgaaggct gtgcactgtg gagagtggcc tgatcaaccc cgtataacca   1860

aagatgtaat ttgttttcat gctgaagatt tcttagaagt agttcaacga atgcagttag   1920

atttacatga acctccactg tcccagtgtg tccaatgggt tgatgatgca aaactgaatc   1980

aactgaggag ggaaggcatt cgctatgcca ggattcagct atatgataat gacatttatt   2040

ttattccaag gaatgttgtt catcagttca agacagtttc agctgtatgc agtttagcat   2100

ggcatattcg gctcaaatta tatcactcag aggaggacac ttctcagaat acagctactc   2160

atgaaacagg cacatcatca gattccacat catctgttct tggacctcac actgacaaca   2220

tgatttgtgc tgtaagcaaa gcctccttgg attctgtttt ttcagataaa cttcattcta   2280

aatatgaatt acagcagatt aaacatgaac ctattgcatc tgtaagaatc aaggaagaac   2340

ctgtgaatgt taatattcct gaaaagacta cagcactgaa taatatggat ggcaagaatg   2400

ttaaagcaaa attggatcat gttcaatttg cagaatttaa gattgacatg gattctaaat   2460

ttgaaaatag caacaaagat ttaaaggaag aattgtgccc tggaaatcta agtctagttg   2520

atacaaggca acacagttca gcacattcaa atcaagataa aaaagacgat gacattttgt   2580

gctaaatttg catataccat ctaaaatcct tttttaaaaa aatttaatgt aataaagatt   2640

catgaattct gaaagcaagc caaggacttg ctcctatgtc tgttacaaaa catagtttat   2700

gtagctttgt aacattcctc agtgcctgtc cataactgtg aagtattaag cacttagggc   2760

cagatgcact gtaaacattg caggtttaaa cataaaggag tctttaaaaa aaaatcattt   2820

acgttggaat tttaggtttt agaatagagc tgacattaac atatatatat atatataaat   2880

atatatatat attttgtaat atgagccaga attctttttc aacaatttaa agcttttcca   2940

tagagcttat ttatatcctt ttttttcatt ttaaatgtgt cagcactgta gtgtaaatag   3000

cttttaaata tctttttagt gtgatttata ctgaaatgtg agccacttaa taaaggttca   3060

tatgttcata ttaataaata tgttttctgt tgagtctgta aagacaaact gacaattcat   3120

ttaagtcatt tgataatgat tctctgctgg tatatctatt tagtgtggta ttgtagtgca   3180

aatgtacgta attcaaatct agtaaatatt taagttcctc                         3220


<210>  478
<211>  846
<212>  PRT
<213>  Homo sapiens

<400>  478

Met Ala Glu Pro Pro Ser Pro Val His Cys Val Ala Ala Ala Ala Pro 
1               5                   10                  15


Thr Ala Thr Val Ser Glu Lys Glu Pro Phe Gly Lys Leu Gln Leu Ser 
            20                  25                  30


Ser Arg Asp Pro Pro Gly Ser Leu Ser Ala Lys Lys Val Arg Thr Glu 
        35                  40                  45


Glu Lys Lys Ala Pro Arg Arg Val Asn Gly Glu Gly Gly Ser Gly Gly 
    50                  55                  60


Asn Ser Arg Gln Leu Gln Pro Pro Ala Ala Pro Ser Pro Gln Ser Tyr 
65                  70                  75                  80


Gly Ser Pro Ala Ser Trp Ser Phe Ala Pro Leu Ser Ala Ala Pro Ser 
                85                  90                  95


Pro Ser Ser Ser Arg Ser Ser Phe Ser Phe Ser Ala Gly Thr Ala Val 
            100                 105                 110


Pro Ser Ser Ala Ser Ala Ser Leu Ser Gln Pro Val Pro Arg Lys Leu 
        115                 120                 125


Leu Val Pro Pro Thr Leu Leu His Ala Gln Pro His His Leu Leu Leu 
    130                 135                 140


Pro Ala Ala Ala Ala Ala Ala Ser Ala Asn Ala Lys Ser Arg Arg Pro 
145                 150                 155                 160


Lys Glu Lys Arg Glu Lys Glu Arg Arg Arg His Gly Leu Gly Gly Ala 
                165                 170                 175


Arg Glu Ala Gly Gly Ala Ser Arg Glu Glu Asn Gly Glu Val Lys Pro 
            180                 185                 190


Leu Pro Arg Asp Lys Ile Lys Asp Lys Ile Lys Glu Arg Asp Lys Glu 
        195                 200                 205


Lys Glu Arg Glu Lys Lys Lys His Lys Val Met Asn Glu Ile Lys Lys 
    210                 215                 220


Glu Asn Gly Glu Val Lys Ile Leu Leu Lys Ser Gly Lys Glu Lys Pro 
225                 230                 235                 240


Lys Thr Asn Ile Glu Asp Leu Gln Ile Lys Lys Val Lys Lys Lys Lys 
                245                 250                 255


Lys Lys Lys His Lys Glu Asn Glu Lys Arg Lys Arg Pro Lys Met Tyr 
            260                 265                 270


Ser Lys Ser Ile Gln Thr Ile Cys Ser Gly Leu Leu Thr Asp Val Glu 
        275                 280                 285


Asp Gln Ala Ala Lys Gly Ile Leu Asn Asp Asn Ile Lys Asp Tyr Val 
    290                 295                 300


Gly Lys Asn Leu Asp Thr Lys Asn Tyr Asp Ser Lys Ile Pro Glu Asn 
305                 310                 315                 320


Ser Glu Phe Pro Phe Val Ser Leu Lys Glu Pro Arg Val Gln Asn Asn 
                325                 330                 335


Leu Lys Arg Leu Asp Thr Leu Glu Phe Lys Gln Leu Ile His Ile Glu 
            340                 345                 350


His Gln Pro Asn Gly Gly Ala Ser Val Ile His Ala Tyr Ser Asn Glu 
        355                 360                 365


Leu Ser His Leu Ser Pro Met Glu Met Glu Arg Phe Ala Glu Glu Phe 
    370                 375                 380


Val Gly Leu Val Phe Ser Glu Asn Glu Asn Ser Ala Ala Phe Tyr Val 
385                 390                 395                 400


Met Gly Ile Val His Gly Ala Ala Thr Tyr Leu Pro Asp Phe Leu Asp 
                405                 410                 415


Tyr Phe Ser Phe Asn Phe Pro Asn Ser Pro Val Lys Met Glu Ile Leu 
            420                 425                 430


Gly Lys Lys Asp Ile Glu Thr Thr Thr Met Ser Asn Phe His Ala Gln 
        435                 440                 445


Val Lys Arg Thr Tyr Ser His Gly Thr Tyr Arg Ala Gly Pro Met Arg 
    450                 455                 460


Gln Ile Ser Leu Val Gly Ala Val Asp Glu Glu Val Gly Asp Tyr Phe 
465                 470                 475                 480


Pro Glu Phe Leu Asp Met Leu Glu Glu Ser Pro Phe Leu Lys Cys Thr 
                485                 490                 495


Leu Pro Trp Gly Thr Leu Ser Ser Leu Lys Leu Gln Ser Arg Lys Asp 
            500                 505                 510


Ser Asp Asp Gly Pro Ile Met Trp Val Arg Pro Gly Glu Gln Met Ile 
        515                 520                 525


Pro Val Ala Asp Met Pro Lys Ser Pro Phe Lys Arg Lys Arg Thr Thr 
    530                 535                 540


Asn Glu Ile Lys Asn Leu Gln Tyr Leu Pro Arg Thr Ser Glu Pro Arg 
545                 550                 555                 560


Glu Met Leu Phe Glu Asp Arg Thr Arg Ala His Ala Asp His Ile Gly 
                565                 570                 575


Gln Gly Phe Glu Arg Gln Thr Thr Ala Ala Val Gly Val Leu Lys Ala 
            580                 585                 590


Val His Cys Gly Glu Trp Pro Asp Gln Pro Arg Ile Thr Lys Asp Val 
        595                 600                 605


Ile Cys Phe His Ala Glu Asp Phe Leu Glu Val Val Gln Arg Met Gln 
    610                 615                 620


Leu Asp Leu His Glu Pro Pro Leu Ser Gln Cys Val Gln Trp Val Asp 
625                 630                 635                 640


Asp Ala Lys Leu Asn Gln Leu Arg Arg Glu Gly Ile Arg Tyr Ala Arg 
                645                 650                 655


Ile Gln Leu Tyr Asp Asn Asp Ile Tyr Phe Ile Pro Arg Asn Val Val 
            660                 665                 670


His Gln Phe Lys Thr Val Ser Ala Val Cys Ser Leu Ala Trp His Ile 
        675                 680                 685


Arg Leu Lys Leu Tyr His Ser Glu Glu Asp Thr Ser Gln Asn Thr Ala 
    690                 695                 700


Thr His Glu Thr Gly Thr Ser Ser Asp Ser Thr Ser Ser Val Leu Gly 
705                 710                 715                 720


Pro His Thr Asp Asn Met Ile Cys Ala Val Ser Lys Ala Ser Leu Asp 
                725                 730                 735


Ser Val Phe Ser Asp Lys Leu His Ser Lys Tyr Glu Leu Gln Gln Ile 
            740                 745                 750


Lys His Glu Pro Ile Ala Ser Val Arg Ile Lys Glu Glu Pro Val Asn 
        755                 760                 765


Val Asn Ile Pro Glu Lys Thr Thr Ala Leu Asn Asn Met Asp Gly Lys 
    770                 775                 780


Asn Val Lys Ala Lys Leu Asp His Val Gln Phe Ala Glu Phe Lys Ile 
785                 790                 795                 800


Asp Met Asp Ser Lys Phe Glu Asn Ser Asn Lys Asp Leu Lys Glu Glu 
                805                 810                 815


Leu Cys Pro Gly Asn Leu Ser Leu Val Asp Thr Arg Gln His Ser Ser 
            820                 825                 830


Ala His Ser Asn Gln Asp Lys Lys Asp Asp Asp Ile Leu Cys 
        835                 840                 845


<210>  479
<211>  883
<212>  DNA
<213>  Homo sapiens

<400>  479
ctgagagatc ctctaccgca gtcgtttgag gaggcggaac tgaagttttt tcttaattat     60

catgtgacgg ggttctggat ttaatggggg gaaaagggcg gaaaaggaca aggatccaaa    120

ctggcgaatt tgctgatctt cgcgtccctc tccgctttcc ggccggcagc gctgccaggg    180

tatatttcct tttttccgat cctgcaacag cctctttaaa ctgtttaaat gagaatgtcc    240

ttggctcaga gagtactact cacctggctt ttcacactac tcttcttgat catgttggtg    300

ttgaaactgg atgagaaagc accttggaac tggttcctca tattcattcc agtctggata    360

tttgatacta tccttcttgt cctgctgatt gtgaaaatgg ctgggcggtg taagtctggc    420

tttgaccctc gacatggatc acacaatatt aaaaaaaaag cctggtacct cattgcaatg    480

ttacttaaat tagccttctg cctcgcactc tgtgctaaac tggaacagtt tactaccatg    540

aatctatcct atgtcttcat tcctttatgg gccttgctgg ctggggcttt aacagaactc    600

ggatataatg tcttttttgt gagagactga cttctaagta catcatctcc tttctattgc    660

tgttcaacaa gttaccatta aagtgttctg aatctgtcaa gcttcaagaa taccagagaa    720

ctgagggaaa ataccaaatg tagttttata ctacttccat aaaacaggat tggtgaatca    780

cggacttcta gtcaacctac agcttaatta ttcagcattt gagttattga gatccttatt    840

atctctatgt aaataaagtt tgttttggac ctcaaaaaaa aaa                      883


<210>  480
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  480

Met Arg Met Ser Leu Ala Gln Arg Val Leu Leu Thr Trp Leu Phe Thr 
1               5                   10                  15


Leu Leu Phe Leu Ile Met Leu Val Leu Lys Leu Asp Glu Lys Ala Pro 
            20                  25                  30


Trp Asn Trp Phe Leu Ile Phe Ile Pro Val Trp Ile Phe Asp Thr Ile 
        35                  40                  45


Leu Leu Val Leu Leu Ile Val Lys Met Ala Gly Arg Cys Lys Ser Gly 
    50                  55                  60


Phe Asp Pro Arg His Gly Ser His Asn Ile Lys Lys Lys Ala Trp Tyr 
65                  70                  75                  80


Leu Ile Ala Met Leu Leu Lys Leu Ala Phe Cys Leu Ala Leu Cys Ala 
                85                  90                  95


Lys Leu Glu Gln Phe Thr Thr Met Asn Leu Ser Tyr Val Phe Ile Pro 
            100                 105                 110


Leu Trp Ala Leu Leu Ala Gly Ala Leu Thr Glu Leu Gly Tyr Asn Val 
        115                 120                 125


Phe Phe Val Arg Asp 
    130


<210>  481
<211>  6880
<212>  DNA
<213>  Homo sapiens

<400>  481
agccttgagt gtcattcaag ggacagcaca acctcatcca agctctccta cctctgccca     60

gccgtccctc tcatcctccc cattcctcgt ccacactcca tccaaagaag agggaaagca    120

ccgaatagag gggggcgaag gcaaagtctg ctgttcttcc ccctgggccc ccttgctcct    180

ccatcctcat tctctcacca ccagcccccc taaccccaag gagcccagga actgaggcga    240

ctcgccccac tgccatgtcc aaaagcttga aaaagaaaag ccactggact agcaaagtcc    300

atgagagtgt cattggcagg aacccggagg gccagctggg ctttgaactg aaggggggcg    360

ccgagaatgg acagttcccc tacctggggg aggtgaagcc cggcaaggtg gcctatgaga    420

gcggcagcaa attggtgtcg gaggagctgc tgctggaggt gaacgagacc cccgtggcgg    480

ggctcaccat cagggacgtg ctggccgtga tcaaacactg caaggacccc ctccggctca    540

agtgtgtcaa gcaaggagga attgttgata aagaccttcg tcactacctc aacttacgat    600

ttcaaaaggg ttctgtggac catgagcttc agcaaatcat tcgtgacaac ctctacctcc    660

gcacggtgcc atgcaccaca aggccacata aggagggtga ggtccctgga gtggattata    720

ttttcatcac tgttgaagat tttatggaat tggagaaaag tggtgctctc ctagaaagtg    780

ggacttatga agacaattac tacggtaccc caaagccgcc agcagaacca gcaccattat    840

tgttaaatgt aacagaccag atacttccag gagccactcc aagtgctgaa ggaaaacgga    900

agaggaataa atcagtgagc aacatggaga aagccagtat agagcctcct gaggaggaag    960

aggaagagag gcctgtggtc aatggaaatg gagtagtagt aacaccagaa tccagtgaac   1020

atgaagacaa aagtgcaggt gcctcagggg agatgccctc ccagccttat cctgcaccag   1080

tgtacagtca gcctgaggag ctgaaggagc agatggatga cacaaagcca actaaacctg   1140

aagacaatga ggaaccagac ccattgcctg ataactggga aatggcctat acagagaagg   1200

gcgaagtcta cttcattgac cataacacaa agacaacatc atggctggat ccacgacttg   1260

cgaaaaaggc taaacctcca gaagagtgca aagaaaatga gcttccatat ggctgggaaa   1320

aaatcgatga tcccatttat ggcacttatt atgttgacca cataaataga agaacacagt   1380

ttgaaaatcc tgtcctggaa gcaaaaagga agctacagca acataacatg ccccacacag   1440

aacttggaac aaagcccctg caggccccag gtttccgaga aaaaccactc ttcacccggg   1500

atgcatccca gttgaaggga acattcctca gcaccaccct aaaaaagagc aacatgggct   1560

ttggatttac catcattggt ggagacgagc ctgatgagtt tctgcaggtg aaaagtgtga   1620

ttccggatgg gcctgcagca caggatggaa aaatggaaac aggtgatgtc attgtctata   1680

ttaatgaagt ttgtgtcctt ggacacactc atgcagatgt tgtcaaactt ttccagtctg   1740

ttcctattgg tcagagtgtc aacctggtgt tgtgtcgtgg ctaccctttg ccctttgatc   1800

ctgaagaccc tgctaacagc atggtgccac cccttgcaat aatggagagg ccacctccag   1860

tgatggtcaa tggaagacac aactatgaaa catatttgga gtacatttct cggacctcac   1920

agtcagttcc agatataaca gatcggccgc ctcattctct gcactccatg ccaactgatg   1980

gtcagctaga cggcacgtat ccaccgcccg tccatgatga caatgtgtct atggcttcat   2040

ctggggccac ccaagctgaa cttatgacct taaccattgt gaaaggtgcc cagggcttcg   2100

gcttcactat tgccgacagt cctacaggac agcgggtgaa acaaatactt gacattcagg   2160

gatgccctgg cctgtgtgaa ggcgacctca ttgttgagat caaccagcag aatgtacaga   2220

acctgagcca tacagaagta gtggatatac ttaaggactg tcccattgga agtgaaactt   2280

ctttgattat ccatcgagga ggtttctttt ctccatggaa aactccaaag cctataatgg   2340

accgatggga gaatcaaggc agtcctcaaa cgagtttatc tgctccggcc ataccgcaga   2400

acctgccctt cccacctgcc cttcacagga gctcctttcc tgactcaaca gaggcctttg   2460

acccacggaa gcctgatcca tatgagctct acgagaaatc tagggccatt tatgaaagta   2520

ggcaacaagt gccacccagg accagttttc gaatggattc ctctggtcca gattataagg   2580

aattggatgt tcatcttcgg aggatggagt ctggatttgg cttcagaatc ctcgggggag   2640

atgagcctgg acagcctatt ttgattggag ctgtcattgc catgggctca gccgacagag   2700

atggccgcct tcacccagga gatgagcttg tgtatgttga tgggattcca gtagccggca   2760

aaacccaccg ctatgtcatc gacctcatgc accacgcagc ccgcaatggg caggtcaacc   2820

tcactgtgag aagaaaggtg ctatgtggag gggagccctg cccagagaac gggagaagtc   2880

caggctctgt atccacccac cacagctctc cacgcagtga ctacgcaacc tacaccaaca   2940

gcaaccacgc tgcccccagt agcaatgcct ctccccctga aggcttcgcc tcccacagcc   3000

tgcagaccag tgatgtggtc attcaccgca aagagaatga gggcttcggc tttgtcatca   3060

tcagctccct gaacaggcct gagtctggat ccactataac tgtgccccat aaaatcggac   3120

gcatcattga tgggagtcct gcagatcgct gtgcaaaact aaaagtggga gaccggatcc   3180

tagcagtgaa tggccagtct atcatcaaca tgcctcacgc tgacatcgtg aagctcatca   3240

aggatgcagg tcttagtgtc acccttcgca tcattcctca ggaggagctc aacagcccca   3300

cctcggcacc cagctcagag aagcagagtc ccatggcgca gcagagtccc ctggcacagc   3360

agagtcccct ggcccagcca agcccagcca cccccaacag ccccatcgcc cagccagcac   3420

cacctcaacc acttcagctg caaggacacg aaaatagtta caggtcggaa gtgaaagcaa   3480

ggcaagatgt gaaaccagac atccgacagc ctccattcac agactacagg cagcccccgc   3540

tggattacag gcaaccccca ggaggggact accagcagcc cccacccttg gactacaggc   3600

agcctcccct actggactac aggcagcact cccccgacac caggcagtac cctctgtcgg   3660

actacagaca accccaggat tttgattatt tcactgtgga catggagaaa ggagccaaag   3720

gatttggatt cagcattcgt ggaggaaggg aatacaaaat ggatttgtat gtgttgagac   3780

tggcagaaga tggaccagca ataaggaatg ggaggatgag ggtaggagat caaatcattg   3840

aaatcaatgg ggaaagcaca agggacatga cacatgccag agcaatagaa ctcatcaaat   3900

ctggaggaag acgagtgagg ctgctgctca agagaggcac gggacaggtc ccagaatatg   3960

acgaacccgc cccctggagt tctcccgctg ccgccgcccc aggtctgccg gaagtaggcg   4020

tctccctgga cgacggcctc gctccattct ctccatcaca tccagcccca ccctccgacc   4080

cttcccacca gataagccca ggcccaactt gggatatcaa acgggaacac gacgttagga   4140

aaccaaagga gctttcagcc tgcggccaga agaagcagcg cctcggggag cagagggagc   4200

gctcggcgag tccgcagagg gccgcgcggc cgaggctcga ggaggcgccc ggcggccagg   4260

ggcggcccga ggccggcagg cccgcctcgg aggccagggc gcccgggctc gcggcggcag   4320

acgcggcgga cgcggcgcgg gcgggcggga aggaggcgcc ccgtgcggcg gcgggctccg   4380

agctctgccg gcgcgaaggc ccgggggctg cgccggcgtt tgccggcccg ggcggcggcg   4440

gcagcggcgc gctggaggcc gagggcaggg cgggtgcgcg cgcgggtccc cggccgggcc   4500

cgcgaccccc ggggggcgcc ccggcgcgca aggccgccgt cgcgccgggg ccctggaagg   4560

tgccgggttc tgacaagctg cccagcgtcc tcaaacccgg cgcctcggcc gccagcagat   4620

gagccgcgcg gccacggcca acccgcccgc cccggcgcag gcagttcttc ttaggttccg   4680

tctcacggcg ttttaattta ttttcactgt cacacgcata gatccacgag gcaccaaggc   4740

ctgggagcat cgacgtgaag tcccacgtgt ccggtgtgct tgggcggcat cgcatcaacg   4800

cgcagaccta aactgatcct aaagcccccg gttcccttgt gggggctttg gcagctatgg   4860

aagaaccaaa ataacgtgaa gaacatcaca gagagacagt gcagtgtagc tttagtttaa   4920

gaaaaaaaaa tattcctccc cactgcatga aggacttgga tgtcatccaa actttatatc   4980

aagaaacagg acaaagttaa gagcaatcac aaactggaat atcgccttaa aaatcaaact   5040

gcacggagca agctgaaact gagacaagat tatatctttt aattgatcta aagcgttgta   5100

aataaattgt tctcgacata tctagacagg ggttaaaggg tttctttgac acattcggaa   5160

ccgttcaccc atgacatgtt tccatggctc acccttggca tccatcctcg gtgttagcag   5220

cagcgttccc tgcctcctgc aggatgactt agaaatctag tgagtttctt ggtgtgatgc   5280

catttttatt gccctttctg tgatcaaatc atatttctgt acattttcag tggtagaaaa   5340

aaaaggtttt aaaaattgta tcctagggaa cagtttgcca taagtcagaa ttttgcagtt   5400

tagctcatag atcttaattg gtttttctct aaaatatgaa ttttataatt gaaggaccac   5460

aatttgttta atcaagatag gcaacgctgc agttccttta tgaagaggct tttctgtcgt   5520

cccaggctag cagagatgga tagcttcttt gtcagcaatg tgatttcact tattttattg   5580

tcttatttta aaccctgtct ccatgacttc atttgcactt tgacagagca gaggcagagt   5640

atttgtctta tatttctcag attataatat taaaaaatta caatcaattt attttcatta   5700

aagaacgtga gtctttttag cattcctttc tgcttatcct tctttcctta ccctttgtcc   5760

ttttgtttcc attagttttc tttcgtcttg tattccttgc cactttattt tgttagcaac   5820

ttctagatgt ttatcttcat ggatctatga ttgacctcct agtaaaattc taagtcttgc   5880

ctttcttccc tgctgtttta gcatttcttt gtaaaatgtt agcttcaatt aattagccat   5940

tggtacttac tgtagctaca catattaaaa ggcaaagtgt ttctgaaggc aatttctttt   6000

taatatgccc gaatgaatga ggcttcatcc tttccatatt cttactcttt acaggagttc   6060

aaatgcaaat aagctccacc tccctgcact tgtagtctaa aaagtaaaag gggcgatcag   6120

gtccatctca aaggtcacac gtaatagcct ccctgggctg atcattccct ctccttgtaa   6180

ttgcagtatc ctgagtagca gtttaatttt catcaaacat cggagtagtt tagttgtttg   6240

acaggaggag aataaggctg aaagcctcaa gtgaaggatc ttgcagcttg taaaagcaat   6300

ttccaaaaat gaaacccatt catcgtaaac aaaagcacaa acacttgtag cagtttataa   6360

tgcttttggt ttaatctcaa ttagtctttc tcccctggac tagaaatcca gtatagtttg   6420

ccattaattt attgaatctg gttttggaca atgcttctgt agtgtagctg cacgtcctgg   6480

tactgtatcc tctgacttta ttttccatgt attacaaaag gaaaaaaaaa ttgagattac   6540

actggcataa actctagttt gcacagttca cagctactac ttgtgcagta attgctttat   6600

gcggctgtaa tccataacct gtgaagacag cacatcatct aaatcccatt ccaaataata   6660

tttgtgtagt gttagctgtg aatttaccct gtacagctgt atctctataa atataattcc   6720

atgtattaat agtcacagaa agactgtaag tgagcaacta tttttatgaa acgtaccact   6780

atggataaat taacttttac agaaatcttg tttactgtat gatattctaa aacactgtca   6840

aataaaatat atatccaaaa atcttttctt tttccaacta                         6880


<210>  482
<211>  1455
<212>  PRT
<213>  Homo sapiens

<400>  482

Met Ser Lys Ser Leu Lys Lys Lys Ser His Trp Thr Ser Lys Val His 
1               5                   10                  15


Glu Ser Val Ile Gly Arg Asn Pro Glu Gly Gln Leu Gly Phe Glu Leu 
            20                  25                  30


Lys Gly Gly Ala Glu Asn Gly Gln Phe Pro Tyr Leu Gly Glu Val Lys 
        35                  40                  45


Pro Gly Lys Val Ala Tyr Glu Ser Gly Ser Lys Leu Val Ser Glu Glu 
    50                  55                  60


Leu Leu Leu Glu Val Asn Glu Thr Pro Val Ala Gly Leu Thr Ile Arg 
65                  70                  75                  80


Asp Val Leu Ala Val Ile Lys His Cys Lys Asp Pro Leu Arg Leu Lys 
                85                  90                  95


Cys Val Lys Gln Gly Gly Ile Val Asp Lys Asp Leu Arg His Tyr Leu 
            100                 105                 110


Asn Leu Arg Phe Gln Lys Gly Ser Val Asp His Glu Leu Gln Gln Ile 
        115                 120                 125


Ile Arg Asp Asn Leu Tyr Leu Arg Thr Val Pro Cys Thr Thr Arg Pro 
    130                 135                 140


His Lys Glu Gly Glu Val Pro Gly Val Asp Tyr Ile Phe Ile Thr Val 
145                 150                 155                 160


Glu Asp Phe Met Glu Leu Glu Lys Ser Gly Ala Leu Leu Glu Ser Gly 
                165                 170                 175


Thr Tyr Glu Asp Asn Tyr Tyr Gly Thr Pro Lys Pro Pro Ala Glu Pro 
            180                 185                 190


Ala Pro Leu Leu Leu Asn Val Thr Asp Gln Ile Leu Pro Gly Ala Thr 
        195                 200                 205


Pro Ser Ala Glu Gly Lys Arg Lys Arg Asn Lys Ser Val Ser Asn Met 
    210                 215                 220


Glu Lys Ala Ser Ile Glu Pro Pro Glu Glu Glu Glu Glu Glu Arg Pro 
225                 230                 235                 240


Val Val Asn Gly Asn Gly Val Val Val Thr Pro Glu Ser Ser Glu His 
                245                 250                 255


Glu Asp Lys Ser Ala Gly Ala Ser Gly Glu Met Pro Ser Gln Pro Tyr 
            260                 265                 270


Pro Ala Pro Val Tyr Ser Gln Pro Glu Glu Leu Lys Glu Gln Met Asp 
        275                 280                 285


Asp Thr Lys Pro Thr Lys Pro Glu Asp Asn Glu Glu Pro Asp Pro Leu 
    290                 295                 300


Pro Asp Asn Trp Glu Met Ala Tyr Thr Glu Lys Gly Glu Val Tyr Phe 
305                 310                 315                 320


Ile Asp His Asn Thr Lys Thr Thr Ser Trp Leu Asp Pro Arg Leu Ala 
                325                 330                 335


Lys Lys Ala Lys Pro Pro Glu Glu Cys Lys Glu Asn Glu Leu Pro Tyr 
            340                 345                 350


Gly Trp Glu Lys Ile Asp Asp Pro Ile Tyr Gly Thr Tyr Tyr Val Asp 
        355                 360                 365


His Ile Asn Arg Arg Thr Gln Phe Glu Asn Pro Val Leu Glu Ala Lys 
    370                 375                 380


Arg Lys Leu Gln Gln His Asn Met Pro His Thr Glu Leu Gly Thr Lys 
385                 390                 395                 400


Pro Leu Gln Ala Pro Gly Phe Arg Glu Lys Pro Leu Phe Thr Arg Asp 
                405                 410                 415


Ala Ser Gln Leu Lys Gly Thr Phe Leu Ser Thr Thr Leu Lys Lys Ser 
            420                 425                 430


Asn Met Gly Phe Gly Phe Thr Ile Ile Gly Gly Asp Glu Pro Asp Glu 
        435                 440                 445


Phe Leu Gln Val Lys Ser Val Ile Pro Asp Gly Pro Ala Ala Gln Asp 
    450                 455                 460


Gly Lys Met Glu Thr Gly Asp Val Ile Val Tyr Ile Asn Glu Val Cys 
465                 470                 475                 480


Val Leu Gly His Thr His Ala Asp Val Val Lys Leu Phe Gln Ser Val 
                485                 490                 495


Pro Ile Gly Gln Ser Val Asn Leu Val Leu Cys Arg Gly Tyr Pro Leu 
            500                 505                 510


Pro Phe Asp Pro Glu Asp Pro Ala Asn Ser Met Val Pro Pro Leu Ala 
        515                 520                 525


Ile Met Glu Arg Pro Pro Pro Val Met Val Asn Gly Arg His Asn Tyr 
    530                 535                 540


Glu Thr Tyr Leu Glu Tyr Ile Ser Arg Thr Ser Gln Ser Val Pro Asp 
545                 550                 555                 560


Ile Thr Asp Arg Pro Pro His Ser Leu His Ser Met Pro Thr Asp Gly 
                565                 570                 575


Gln Leu Asp Gly Thr Tyr Pro Pro Pro Val His Asp Asp Asn Val Ser 
            580                 585                 590


Met Ala Ser Ser Gly Ala Thr Gln Ala Glu Leu Met Thr Leu Thr Ile 
        595                 600                 605


Val Lys Gly Ala Gln Gly Phe Gly Phe Thr Ile Ala Asp Ser Pro Thr 
    610                 615                 620


Gly Gln Arg Val Lys Gln Ile Leu Asp Ile Gln Gly Cys Pro Gly Leu 
625                 630                 635                 640


Cys Glu Gly Asp Leu Ile Val Glu Ile Asn Gln Gln Asn Val Gln Asn 
                645                 650                 655


Leu Ser His Thr Glu Val Val Asp Ile Leu Lys Asp Cys Pro Ile Gly 
            660                 665                 670


Ser Glu Thr Ser Leu Ile Ile His Arg Gly Gly Phe Phe Ser Pro Trp 
        675                 680                 685


Lys Thr Pro Lys Pro Ile Met Asp Arg Trp Glu Asn Gln Gly Ser Pro 
    690                 695                 700


Gln Thr Ser Leu Ser Ala Pro Ala Ile Pro Gln Asn Leu Pro Phe Pro 
705                 710                 715                 720


Pro Ala Leu His Arg Ser Ser Phe Pro Asp Ser Thr Glu Ala Phe Asp 
                725                 730                 735


Pro Arg Lys Pro Asp Pro Tyr Glu Leu Tyr Glu Lys Ser Arg Ala Ile 
            740                 745                 750


Tyr Glu Ser Arg Gln Gln Val Pro Pro Arg Thr Ser Phe Arg Met Asp 
        755                 760                 765


Ser Ser Gly Pro Asp Tyr Lys Glu Leu Asp Val His Leu Arg Arg Met 
    770                 775                 780


Glu Ser Gly Phe Gly Phe Arg Ile Leu Gly Gly Asp Glu Pro Gly Gln 
785                 790                 795                 800


Pro Ile Leu Ile Gly Ala Val Ile Ala Met Gly Ser Ala Asp Arg Asp 
                805                 810                 815


Gly Arg Leu His Pro Gly Asp Glu Leu Val Tyr Val Asp Gly Ile Pro 
            820                 825                 830


Val Ala Gly Lys Thr His Arg Tyr Val Ile Asp Leu Met His His Ala 
        835                 840                 845


Ala Arg Asn Gly Gln Val Asn Leu Thr Val Arg Arg Lys Val Leu Cys 
    850                 855                 860


Gly Gly Glu Pro Cys Pro Glu Asn Gly Arg Ser Pro Gly Ser Val Ser 
865                 870                 875                 880


Thr His His Ser Ser Pro Arg Ser Asp Tyr Ala Thr Tyr Thr Asn Ser 
                885                 890                 895


Asn His Ala Ala Pro Ser Ser Asn Ala Ser Pro Pro Glu Gly Phe Ala 
            900                 905                 910


Ser His Ser Leu Gln Thr Ser Asp Val Val Ile His Arg Lys Glu Asn 
        915                 920                 925


Glu Gly Phe Gly Phe Val Ile Ile Ser Ser Leu Asn Arg Pro Glu Ser 
    930                 935                 940


Gly Ser Thr Ile Thr Val Pro His Lys Ile Gly Arg Ile Ile Asp Gly 
945                 950                 955                 960


Ser Pro Ala Asp Arg Cys Ala Lys Leu Lys Val Gly Asp Arg Ile Leu 
                965                 970                 975


Ala Val Asn Gly Gln Ser Ile Ile Asn Met Pro His Ala Asp Ile Val 
            980                 985                 990


Lys Leu Ile Lys Asp Ala Gly Leu Ser Val Thr Leu Arg Ile Ile Pro 
        995                 1000                1005


Gln Glu Glu Leu Asn Ser Pro Thr Ser Ala Pro Ser Ser Glu Lys Gln 
    1010                1015                1020


Ser Pro Met Ala Gln Gln Ser Pro Leu Ala Gln Gln Ser Pro Leu Ala 
1025                1030                1035                1040


Gln Pro Ser Pro Ala Thr Pro Asn Ser Pro Ile Ala Gln Pro Ala Pro 
                1045                1050                1055


Pro Gln Pro Leu Gln Leu Gln Gly His Glu Asn Ser Tyr Arg Ser Glu 
            1060                1065                1070


Val Lys Ala Arg Gln Asp Val Lys Pro Asp Ile Arg Gln Pro Pro Phe 
        1075                1080                1085


Thr Asp Tyr Arg Gln Pro Pro Leu Asp Tyr Arg Gln Pro Pro Gly Gly 
    1090                1095                1100


Asp Tyr Gln Gln Pro Pro Pro Leu Asp Tyr Arg Gln Pro Pro Leu Leu 
1105                1110                1115                1120


Asp Tyr Arg Gln His Ser Pro Asp Thr Arg Gln Tyr Pro Leu Ser Asp 
                1125                1130                1135


Tyr Arg Gln Pro Gln Asp Phe Asp Tyr Phe Thr Val Asp Met Glu Lys 
            1140                1145                1150


Gly Ala Lys Gly Phe Gly Phe Ser Ile Arg Gly Gly Arg Glu Tyr Lys 
        1155                1160                1165


Met Asp Leu Tyr Val Leu Arg Leu Ala Glu Asp Gly Pro Ala Ile Arg 
    1170                1175                1180


Asn Gly Arg Met Arg Val Gly Asp Gln Ile Ile Glu Ile Asn Gly Glu 
1185                1190                1195                1200


Ser Thr Arg Asp Met Thr His Ala Arg Ala Ile Glu Leu Ile Lys Ser 
                1205                1210                1215


Gly Gly Arg Arg Val Arg Leu Leu Leu Lys Arg Gly Thr Gly Gln Val 
            1220                1225                1230


Pro Glu Tyr Asp Glu Pro Ala Pro Trp Ser Ser Pro Ala Ala Ala Ala 
        1235                1240                1245


Pro Gly Leu Pro Glu Val Gly Val Ser Leu Asp Asp Gly Leu Ala Pro 
    1250                1255                1260


Phe Ser Pro Ser His Pro Ala Pro Pro Ser Asp Pro Ser His Gln Ile 
1265                1270                1275                1280


Ser Pro Gly Pro Thr Trp Asp Ile Lys Arg Glu His Asp Val Arg Lys 
                1285                1290                1295


Pro Lys Glu Leu Ser Ala Cys Gly Gln Lys Lys Gln Arg Leu Gly Glu 
            1300                1305                1310


Gln Arg Glu Arg Ser Ala Ser Pro Gln Arg Ala Ala Arg Pro Arg Leu 
        1315                1320                1325


Glu Glu Ala Pro Gly Gly Gln Gly Arg Pro Glu Ala Gly Arg Pro Ala 
    1330                1335                1340


Ser Glu Ala Arg Ala Pro Gly Leu Ala Ala Ala Asp Ala Ala Asp Ala 
1345                1350                1355                1360


Ala Arg Ala Gly Gly Lys Glu Ala Pro Arg Ala Ala Ala Gly Ser Glu 
                1365                1370                1375


Leu Cys Arg Arg Glu Gly Pro Gly Ala Ala Pro Ala Phe Ala Gly Pro 
            1380                1385                1390


Gly Gly Gly Gly Ser Gly Ala Leu Glu Ala Glu Gly Arg Ala Gly Ala 
        1395                1400                1405


Arg Ala Gly Pro Arg Pro Gly Pro Arg Pro Pro Gly Gly Ala Pro Ala 
    1410                1415                1420


Arg Lys Ala Ala Val Ala Pro Gly Pro Trp Lys Val Pro Gly Ser Asp 
1425                1430                1435                1440


Lys Leu Pro Ser Val Leu Lys Pro Gly Ala Ser Ala Ala Ser Arg 
                1445                1450                1455


<210>  483
<211>  4872
<212>  DNA
<213>  Homo sapiens

<400>  483
tattcagata ttctccagat tcctaaagat tagagatcat ttctcattct cctaggagta     60

ctcacttcag gaagcaacca gataaaagag aggtgcaacg gaagccagaa cattcctcct    120

ggaaattcaa cctgtttcgc agtttctcga ggaatcagca ttcagtcaat ccgggccggg    180

agcagtcatc tgtggtgagg ctgattggct gggcaggaac agcgccgggg cgtgggctga    240

gcacagccgc ttcgctctct ttgccacagg aagcctgagc tcattcgagt agcggctctt    300

ccaagctcaa agaagcagag gccgctgttc gtttccttta ggtctttcca ctaaagtcgg    360

agtatcttct tccaaaattt cacgtcttgg tggccgttcc aaggagcgcg aggtcggaat    420

ggatcttgaa ggggaccgca atggaggagc aaagaagaag aactttttta aactgaacaa    480

taaaagtgaa aaagataaga aggaaaagaa accaactgtc agtgtatttt caatgtttcg    540

ctattcaaat tggcttgaca agttgtatat ggtggtggga actttggctg ccatcatcca    600

tggggctgga cttcctctca tgatgctggt gtttggagaa atgacagata tctttgcaaa    660

tgcaggaaat ttagaagatc tgatgtcaaa catcactaat agaagtgata tcaatgatac    720

agggttcttc atgaatctgg aggaagacat gaccaggtat gcctattatt acagtggaat    780

tggtgctggg gtgctggttg ctgcttacat tcaggtttca ttttggtgcc tggcagctgg    840

aagacaaata cacaaaatta gaaaacagtt ttttcatgct ataatgcgac aggagatagg    900

ctggtttgat gtgcacgatg ttggggagct taacacccga cttacagatg atgtctccaa    960

gattaatgaa ggaattggtg acaaaattgg aatgttcttt cagtcaatgg caacattttt   1020

cactgggttt atagtaggat ttacacgtgg ttggaagcta acccttgtga ttttggccat   1080

cagtcctgtt cttggactgt cagctgctgt ctgggcaaag atactatctt catttactga   1140

taaagaactc ttagcgtatg caaaagctgg agcagtagct gaagaggtct tggcagcaat   1200

tagaactgtg attgcatttg gaggacaaaa gaaagaactt gaaaggtaca acaaaaattt   1260

agaagaagct aaaagaattg ggataaagaa agctattaca gccaatattt ctataggtgc   1320

tgctttcctg ctgatctatg catcttatgc tctggccttc tggtatggga ccaccttggt   1380

cctctcaggg gaatattcta ttggacaagt actcactgta ttcttttctg tattaattgg   1440

ggcttttagt gttggacagg catctccaag cattgaagca tttgcaaatg caagaggagc   1500

agcttatgaa atcttcaaga taattgataa taagccaagt attgacagct attcgaagag   1560

tgggcacaaa ccagataata ttaagggaaa tttggaattc agaaatgttc acttcagtta   1620

cccatctcga aaagaagtta agatcttgaa gggtctgaac ctgaaggtgc agagtgggca   1680

gacggtggcc ctggttggaa acagtggctg tgggaagagc acaacagtcc agctgatgca   1740

gaggctctat gaccccacag aggggatggt cagtgttgat ggacaggata ttaggaccat   1800

aaatgtaagg tttctacggg aaatcattgg tgtggtgagt caggaacctg tattgtttgc   1860

caccacgata gctgaaaaca ttcgctatgg ccgtgaaaat gtcaccatgg atgagattga   1920

gaaagctgtc aaggaagcca atgcctatga ctttatcatg aaactgcctc ataaatttga   1980

caccctggtt ggagagagag gggcccagtt gagtggtggg cagaagcaga ggatcgccat   2040

tgcacgtgcc ctggttcgca accccaagat cctcctgctg gatgaggcca cgtcagcctt   2100

ggacacagaa agcgaagcag tggttcaggt ggctctggat aaggccagaa aaggtcggac   2160

caccattgtg atagctcatc gtttgtctac agttcgtaat gctgacgtca tcgctggttt   2220

cgatgatgga gtcattgtgg agaaaggaaa tcatgatgaa ctcatgaaag agaaaggcat   2280

ttacttcaaa cttgtcacaa tgcagacagc aggaaatgaa gttgaattag aaaatgcagc   2340

tgatgaatcc aaaagtgaaa ttgatgcctt ggaaatgtct tcaaatgatt caagatccag   2400

tctaataaga aaaagatcaa ctcgtaggag tgtccgtgga tcacaagccc aagacagaaa   2460

gcttagtacc aaagaggctc tggatgaaag tatacctcca gtttcctttt ggaggattat   2520

gaagctaaat ttaactgaat ggccttattt tgttgttggt gtattttgtg ccattataaa   2580

tggaggcctg caaccagcat ttgcaataat attttcaaag attatagggg tttttacaag   2640

aattgatgat cctgaaacaa aacgacagaa tagtaacttg ttttcactat tgtttctagc   2700

ccttggaatt atttctttta ttacattttt ccttcagggt ttcacatttg gcaaagctgg   2760

agagatcctc accaagcggc tccgatacat ggttttccga tccatgctca gacaggatgt   2820

gagttggttt gatgacccta aaaacaccac tggagcattg actaccaggc tcgccaatga   2880

tgctgctcaa gttaaagggg ctataggttc caggcttgct gtaattaccc agaatatagc   2940

aaatcttggg acaggaataa ttatatcctt catctatggt tggcaactaa cactgttact   3000

cttagcaatt gtacccatca ttgcaatagc aggagttgtt gaaatgaaaa tgttgtctgg   3060

acaagcactg aaagataaga aagaactaga aggttctggg aagatcgcta ctgaagcaat   3120

agaaaacttc cgaaccgttg tttctttgac tcaggagcag aagtttgaac atatgtatgc   3180

tcagagtttg caggtaccat acagaaactc tttgaggaaa gcacacatct ttggaattac   3240

attttccttc acccaggcaa tgatgtattt ttcctatgct ggatgtttcc ggtttggagc   3300

ctacttggtg gcacataaac tcatgagctt tgaggatgtt ctgttagtat tttcagctgt   3360

tgtctttggt gccatggccg tggggcaagt cagttcattt gctcctgact atgccaaagc   3420

caaaatatca gcagcccaca tcatcatgat cattgaaaaa acccctttga ttgacagcta   3480

cagcacggaa ggcctaatgc cgaacacatt ggaaggaaat gtcacatttg gtgaagttgt   3540

attcaactat cccacccgac cggacatccc agtgcttcag ggactgagcc tggaggtgaa   3600

gaagggccag acgctggctc tggtgggcag cagtggctgt gggaagagca cagtggtcca   3660

gctcctggag cggttctacg accccttggc agggaaagtg ctgcttgatg gcaaagaaat   3720

aaagcgactg aatgttcagt ggctccgagc acacctgggc atcgtgtccc aggagcccat   3780

cctgtttgac tgcagcattg ctgagaacat tgcctatgga gacaacagcc gggtggtgtc   3840

acaggaagag attgtgaggg cagcaaagga ggccaacata catgccttca tcgagtcact   3900

gcctaataaa tatagcacta aagtaggaga caaaggaact cagctctctg gtggccagaa   3960

acaacgcatt gccatagctc gtgcccttgt tagacagcct catattttgc ttttggatga   4020

agccacgtca gctctggata cagaaagtga aaaggttgtc caagaagccc tggacaaagc   4080

cagagaaggc cgcacctgca ttgtgattgc tcaccgcctg tccaccatcc agaatgcaga   4140

cttaatagtg gtgtttcaga atggcagagt caaggagcat ggcacgcatc agcagctgct   4200

ggcacagaaa ggcatctatt tttcaatggt cagtgtccag gctggaacaa agcgccagtg   4260

aactctgact gtatgagatg ttaaatactt tttaatattt gtttagatat gacatttatt   4320

caaagttaaa agcaaacact tacagaatta tgaagaggta tctgtttaac atttcctcag   4380

tcaagttcag agtcttcaga gacttcgtaa ttaaaggaac agagtgagag acatcatcaa   4440

gtggagagaa atcatagttt aaactgcatt ataaatttta taacagaatt aaagtagatt   4500

ttaaaagata aaatgtgtaa ttttgtttat attttcccat ttggactgta actgactgcc   4560

ttgctaaaag attatagaag tagcaaaaag tattgaaatg tttgcataaa gtgtctataa   4620

taaaactaaa ctttcatgtg actggagtca tcttgtccaa actgcctgtg aatatatctt   4680

ctctcaattg gaatattgta gataacttct gctttaaaaa agttttcttt aaatatacct   4740

actcattttt gtgggaatgg ttaagcagtt taaataattc ctgttgtata tgtctattca   4800

cattgggtct tacagaacca tctggcttca ttcttcttgg acttgatcct gctgattctt   4860

gcatttccac at                                                       4872


<210>  484
<211>  1280
<212>  PRT
<213>  Homo sapiens

<400>  484

Met Asp Leu Glu Gly Asp Arg Asn Gly Gly Ala Lys Lys Lys Asn Phe 
1               5                   10                  15


Phe Lys Leu Asn Asn Lys Ser Glu Lys Asp Lys Lys Glu Lys Lys Pro 
            20                  25                  30


Thr Val Ser Val Phe Ser Met Phe Arg Tyr Ser Asn Trp Leu Asp Lys 
        35                  40                  45


Leu Tyr Met Val Val Gly Thr Leu Ala Ala Ile Ile His Gly Ala Gly 
    50                  55                  60


Leu Pro Leu Met Met Leu Val Phe Gly Glu Met Thr Asp Ile Phe Ala 
65                  70                  75                  80


Asn Ala Gly Asn Leu Glu Asp Leu Met Ser Asn Ile Thr Asn Arg Ser 
                85                  90                  95


Asp Ile Asn Asp Thr Gly Phe Phe Met Asn Leu Glu Glu Asp Met Thr 
            100                 105                 110


Arg Tyr Ala Tyr Tyr Tyr Ser Gly Ile Gly Ala Gly Val Leu Val Ala 
        115                 120                 125


Ala Tyr Ile Gln Val Ser Phe Trp Cys Leu Ala Ala Gly Arg Gln Ile 
    130                 135                 140


His Lys Ile Arg Lys Gln Phe Phe His Ala Ile Met Arg Gln Glu Ile 
145                 150                 155                 160


Gly Trp Phe Asp Val His Asp Val Gly Glu Leu Asn Thr Arg Leu Thr 
                165                 170                 175


Asp Asp Val Ser Lys Ile Asn Glu Gly Ile Gly Asp Lys Ile Gly Met 
            180                 185                 190


Phe Phe Gln Ser Met Ala Thr Phe Phe Thr Gly Phe Ile Val Gly Phe 
        195                 200                 205


Thr Arg Gly Trp Lys Leu Thr Leu Val Ile Leu Ala Ile Ser Pro Val 
    210                 215                 220


Leu Gly Leu Ser Ala Ala Val Trp Ala Lys Ile Leu Ser Ser Phe Thr 
225                 230                 235                 240


Asp Lys Glu Leu Leu Ala Tyr Ala Lys Ala Gly Ala Val Ala Glu Glu 
                245                 250                 255


Val Leu Ala Ala Ile Arg Thr Val Ile Ala Phe Gly Gly Gln Lys Lys 
            260                 265                 270


Glu Leu Glu Arg Tyr Asn Lys Asn Leu Glu Glu Ala Lys Arg Ile Gly 
        275                 280                 285


Ile Lys Lys Ala Ile Thr Ala Asn Ile Ser Ile Gly Ala Ala Phe Leu 
    290                 295                 300


Leu Ile Tyr Ala Ser Tyr Ala Leu Ala Phe Trp Tyr Gly Thr Thr Leu 
305                 310                 315                 320


Val Leu Ser Gly Glu Tyr Ser Ile Gly Gln Val Leu Thr Val Phe Phe 
                325                 330                 335


Ser Val Leu Ile Gly Ala Phe Ser Val Gly Gln Ala Ser Pro Ser Ile 
            340                 345                 350


Glu Ala Phe Ala Asn Ala Arg Gly Ala Ala Tyr Glu Ile Phe Lys Ile 
        355                 360                 365


Ile Asp Asn Lys Pro Ser Ile Asp Ser Tyr Ser Lys Ser Gly His Lys 
    370                 375                 380


Pro Asp Asn Ile Lys Gly Asn Leu Glu Phe Arg Asn Val His Phe Ser 
385                 390                 395                 400


Tyr Pro Ser Arg Lys Glu Val Lys Ile Leu Lys Gly Leu Asn Leu Lys 
                405                 410                 415


Val Gln Ser Gly Gln Thr Val Ala Leu Val Gly Asn Ser Gly Cys Gly 
            420                 425                 430


Lys Ser Thr Thr Val Gln Leu Met Gln Arg Leu Tyr Asp Pro Thr Glu 
        435                 440                 445


Gly Met Val Ser Val Asp Gly Gln Asp Ile Arg Thr Ile Asn Val Arg 
    450                 455                 460


Phe Leu Arg Glu Ile Ile Gly Val Val Ser Gln Glu Pro Val Leu Phe 
465                 470                 475                 480


Ala Thr Thr Ile Ala Glu Asn Ile Arg Tyr Gly Arg Glu Asn Val Thr 
                485                 490                 495


Met Asp Glu Ile Glu Lys Ala Val Lys Glu Ala Asn Ala Tyr Asp Phe 
            500                 505                 510


Ile Met Lys Leu Pro His Lys Phe Asp Thr Leu Val Gly Glu Arg Gly 
        515                 520                 525


Ala Gln Leu Ser Gly Gly Gln Lys Gln Arg Ile Ala Ile Ala Arg Ala 
    530                 535                 540


Leu Val Arg Asn Pro Lys Ile Leu Leu Leu Asp Glu Ala Thr Ser Ala 
545                 550                 555                 560


Leu Asp Thr Glu Ser Glu Ala Val Val Gln Val Ala Leu Asp Lys Ala 
                565                 570                 575


Arg Lys Gly Arg Thr Thr Ile Val Ile Ala His Arg Leu Ser Thr Val 
            580                 585                 590


Arg Asn Ala Asp Val Ile Ala Gly Phe Asp Asp Gly Val Ile Val Glu 
        595                 600                 605


Lys Gly Asn His Asp Glu Leu Met Lys Glu Lys Gly Ile Tyr Phe Lys 
    610                 615                 620


Leu Val Thr Met Gln Thr Ala Gly Asn Glu Val Glu Leu Glu Asn Ala 
625                 630                 635                 640


Ala Asp Glu Ser Lys Ser Glu Ile Asp Ala Leu Glu Met Ser Ser Asn 
                645                 650                 655


Asp Ser Arg Ser Ser Leu Ile Arg Lys Arg Ser Thr Arg Arg Ser Val 
            660                 665                 670


Arg Gly Ser Gln Ala Gln Asp Arg Lys Leu Ser Thr Lys Glu Ala Leu 
        675                 680                 685


Asp Glu Ser Ile Pro Pro Val Ser Phe Trp Arg Ile Met Lys Leu Asn 
    690                 695                 700


Leu Thr Glu Trp Pro Tyr Phe Val Val Gly Val Phe Cys Ala Ile Ile 
705                 710                 715                 720


Asn Gly Gly Leu Gln Pro Ala Phe Ala Ile Ile Phe Ser Lys Ile Ile 
                725                 730                 735


Gly Val Phe Thr Arg Ile Asp Asp Pro Glu Thr Lys Arg Gln Asn Ser 
            740                 745                 750


Asn Leu Phe Ser Leu Leu Phe Leu Ala Leu Gly Ile Ile Ser Phe Ile 
        755                 760                 765


Thr Phe Phe Leu Gln Gly Phe Thr Phe Gly Lys Ala Gly Glu Ile Leu 
    770                 775                 780


Thr Lys Arg Leu Arg Tyr Met Val Phe Arg Ser Met Leu Arg Gln Asp 
785                 790                 795                 800


Val Ser Trp Phe Asp Asp Pro Lys Asn Thr Thr Gly Ala Leu Thr Thr 
                805                 810                 815


Arg Leu Ala Asn Asp Ala Ala Gln Val Lys Gly Ala Ile Gly Ser Arg 
            820                 825                 830


Leu Ala Val Ile Thr Gln Asn Ile Ala Asn Leu Gly Thr Gly Ile Ile 
        835                 840                 845


Ile Ser Phe Ile Tyr Gly Trp Gln Leu Thr Leu Leu Leu Leu Ala Ile 
    850                 855                 860


Val Pro Ile Ile Ala Ile Ala Gly Val Val Glu Met Lys Met Leu Ser 
865                 870                 875                 880


Gly Gln Ala Leu Lys Asp Lys Lys Glu Leu Glu Gly Ser Gly Lys Ile 
                885                 890                 895


Ala Thr Glu Ala Ile Glu Asn Phe Arg Thr Val Val Ser Leu Thr Gln 
            900                 905                 910


Glu Gln Lys Phe Glu His Met Tyr Ala Gln Ser Leu Gln Val Pro Tyr 
        915                 920                 925


Arg Asn Ser Leu Arg Lys Ala His Ile Phe Gly Ile Thr Phe Ser Phe 
    930                 935                 940


Thr Gln Ala Met Met Tyr Phe Ser Tyr Ala Gly Cys Phe Arg Phe Gly 
945                 950                 955                 960


Ala Tyr Leu Val Ala His Lys Leu Met Ser Phe Glu Asp Val Leu Leu 
                965                 970                 975


Val Phe Ser Ala Val Val Phe Gly Ala Met Ala Val Gly Gln Val Ser 
            980                 985                 990


Ser Phe Ala Pro Asp Tyr Ala Lys Ala Lys Ile Ser Ala Ala His Ile 
        995                 1000                1005


Ile Met Ile Ile Glu Lys Thr Pro Leu Ile Asp Ser Tyr Ser Thr Glu 
    1010                1015                1020


Gly Leu Met Pro Asn Thr Leu Glu Gly Asn Val Thr Phe Gly Glu Val 
1025                1030                1035                1040


Val Phe Asn Tyr Pro Thr Arg Pro Asp Ile Pro Val Leu Gln Gly Leu 
                1045                1050                1055


Ser Leu Glu Val Lys Lys Gly Gln Thr Leu Ala Leu Val Gly Ser Ser 
            1060                1065                1070


Gly Cys Gly Lys Ser Thr Val Val Gln Leu Leu Glu Arg Phe Tyr Asp 
        1075                1080                1085


Pro Leu Ala Gly Lys Val Leu Leu Asp Gly Lys Glu Ile Lys Arg Leu 
    1090                1095                1100


Asn Val Gln Trp Leu Arg Ala His Leu Gly Ile Val Ser Gln Glu Pro 
1105                1110                1115                1120


Ile Leu Phe Asp Cys Ser Ile Ala Glu Asn Ile Ala Tyr Gly Asp Asn 
                1125                1130                1135


Ser Arg Val Val Ser Gln Glu Glu Ile Val Arg Ala Ala Lys Glu Ala 
            1140                1145                1150


Asn Ile His Ala Phe Ile Glu Ser Leu Pro Asn Lys Tyr Ser Thr Lys 
        1155                1160                1165


Val Gly Asp Lys Gly Thr Gln Leu Ser Gly Gly Gln Lys Gln Arg Ile 
    1170                1175                1180


Ala Ile Ala Arg Ala Leu Val Arg Gln Pro His Ile Leu Leu Leu Asp 
1185                1190                1195                1200


Glu Ala Thr Ser Ala Leu Asp Thr Glu Ser Glu Lys Val Val Gln Glu 
                1205                1210                1215


Ala Leu Asp Lys Ala Arg Glu Gly Arg Thr Cys Ile Val Ile Ala His 
            1220                1225                1230


Arg Leu Ser Thr Ile Gln Asn Ala Asp Leu Ile Val Val Phe Gln Asn 
        1235                1240                1245


Gly Arg Val Lys Glu His Gly Thr His Gln Gln Leu Leu Ala Gln Lys 
    1250                1255                1260


Gly Ile Tyr Phe Ser Met Val Ser Val Gln Ala Gly Thr Lys Arg Gln 
1265                1270                1275                1280


<210>  485
<211>  2241
<212>  DNA
<213>  Homo sapiens

<400>  485
gctggggcac gagtggctgc ggagtgtggg tggttgggcg tgaggggccg acgggctcgc     60

gcgcgcgccg tctgctgagg tccctcggga aggaggagag cgcctgacgc cgacccgcag    120

gcgcagcccg gcagtcggcg gcgcgccgag ggcggaggtg gtgcgtgcgt gcgtgtgtgt    180

gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt ggagctcggg tgccaagggc gagccgtcag    240

tccccgggtg cgagtccctg ctgtcttcca cacccttcct ccctccaggc tcctttccta    300

catccttccc gcgcccccac ggttgcggac cgagcgagaa cccccttaag caggtgtggg    360

gggcgtgcgg ggtggcacga gacaaaaggg gcacgggggt aagcccgcca tggcctcccg    420

gagcctgggg ggcctgagcg ggatccgcgg cggtggcggc ggaggcggca agaaaagcct    480

gagcgcccgc aatgctgcgg tggagaggag gaacctgatc accgtgtgca ggttttctgt    540

gaagaccctg attgatcggt cttgctttga gacaattgat gattcttctc ctgaatttaa    600

caattttgca gctattttgg aacagatttt aagccaccgg ctaaaagaga tttcccaaag    660

ttgcagatgg ctggctcatc tccaaatacc tcttcaaggt caagtaacct ggtttggtta    720

tgaaagtcct cgtagcttct gggactatat cagagtggct tgccggaaag tttcacagaa    780

ttgtatctgc agcattgaaa atatggaaaa tgtcagttct tctagagcta agggtagagc    840

ctggatcaga gtagcactca tggaaaaaca tttatctgaa tacatctcta cagctctgag    900

agacttcaaa acaaccagga gattttatga agatggagca attgtcttgg gtgaagaagc    960

aaatatgctt gctggcatgc ttctaggact caatgctatt gatttcagtt tctgcctaaa   1020

gggagagggg ctggatggca gttttcctgc tgtaatagac tatacaccat atttgaagta   1080

tatccaaagt tctgatagta tcagcagtga tgaggaggag ctaaggactt tgggaagcag   1140

tggtagcgaa agcagtactc cagagaatgt cggacctcct ttcctcatgg atgagaacag   1200

ttggttcaac aagtgtaaga gagttaaaca aaagtatcag cttaccctgg aacagaaggg   1260

ttaccttgaa gaactcttac gacttcgaga gaaccaacta tctgaatctg tctcccagaa   1320

taaaatacta cttcaaagga ttgaagattc cgatctggct cataaactgg agaaggaaca   1380

attagaatat ataattgtgg agcttcaaga tcagctgact gtgctaaaga ataatgattt   1440

aagatcgaga caagagttaa ctgcccatct caccaaccag tggccttctc caggagctct   1500

ggatgtcaat gctgttgcct tggatacgtt gctttaccga aaacacaata aacagtggta   1560

tgagaaaagt tatcaaagtc ttgaccagtt atcagcagaa gttagccttt ctcagacttc   1620

actagatcca ggccagtcac aagaaggaga tggaaaacaa gacacattaa atgtaatgag   1680

tgaaggtaag gaagatactc cctcattact tggcctctgt ggatctctaa cgtcagtggc   1740

aagttacaag tctctaacaa gcttaaaatc taatgactac cttgcaagtc ctacaacaga   1800

gatgacaagt ccaggcctaa ctccatcctg aaaatttttg tgtaaaagcc aaaacttttt   1860

atgttgtaaa tgtttaattt acatgtttga ctgctgggaa gacctttgaa attttatatt   1920

gttctggtac atgtctgaaa ttctattgct tggagagaat cccctccaga taagagattt   1980

tgagtgaaaa acataatgat cctgccattt ttcattttta aaattcttac atttgtcatt   2040

gagaaagttc aaaatggaat aggctttaaa aaaaaaaaaa ctttcaaaga tccgccaaat   2100

cattcatagc aaattgtaca tattgttcag ctgattttta tatatttaaa tacaccttag   2160

tggccagaga ctgacttcaa ggttttattc cagagactcc agagacttaa gctaagtatt   2220

ttttcattct ttcagatttt c                                             2241


<210>  486
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  486

Met Ala Ser Arg Ser Leu Gly Gly Leu Ser Gly Ile Arg Gly Gly Gly 
1               5                   10                  15


Gly Gly Gly Gly Lys Lys Ser Leu Ser Ala Arg Asn Ala Ala Val Glu 
            20                  25                  30


Arg Arg Asn Leu Ile Thr Val Cys Arg Phe Ser Val Lys Thr Leu Ile 
        35                  40                  45


Asp Arg Ser Cys Phe Glu Thr Ile Asp Asp Ser Ser Pro Glu Phe Asn 
    50                  55                  60


Asn Phe Ala Ala Ile Leu Glu Gln Ile Leu Ser His Arg Leu Lys Glu 
65                  70                  75                  80


Ile Ser Gln Ser Cys Arg Trp Leu Ala His Leu Gln Ile Pro Leu Gln 
                85                  90                  95


Gly Gln Val Thr Trp Phe Gly Tyr Glu Ser Pro Arg Ser Phe Trp Asp 
            100                 105                 110


Tyr Ile Arg Val Ala Cys Arg Lys Val Ser Gln Asn Cys Ile Cys Ser 
        115                 120                 125


Ile Glu Asn Met Glu Asn Val Ser Ser Ser Arg Ala Lys Gly Arg Ala 
    130                 135                 140


Trp Ile Arg Val Ala Leu Met Glu Lys His Leu Ser Glu Tyr Ile Ser 
145                 150                 155                 160


Thr Ala Leu Arg Asp Phe Lys Thr Thr Arg Arg Phe Tyr Glu Asp Gly 
                165                 170                 175


Ala Ile Val Leu Gly Glu Glu Ala Asn Met Leu Ala Gly Met Leu Leu 
            180                 185                 190


Gly Leu Asn Ala Ile Asp Phe Ser Phe Cys Leu Lys Gly Glu Gly Leu 
        195                 200                 205


Asp Gly Ser Phe Pro Ala Val Ile Asp Tyr Thr Pro Tyr Leu Lys Tyr 
    210                 215                 220


Ile Gln Ser Ser Asp Ser Ile Ser Ser Asp Glu Glu Glu Leu Arg Thr 
225                 230                 235                 240


Leu Gly Ser Ser Gly Ser Glu Ser Ser Thr Pro Glu Asn Val Gly Pro 
                245                 250                 255


Pro Phe Leu Met Asp Glu Asn Ser Trp Phe Asn Lys Cys Lys Arg Val 
            260                 265                 270


Lys Gln Lys Tyr Gln Leu Thr Leu Glu Gln Lys Gly Tyr Leu Glu Glu 
        275                 280                 285


Leu Leu Arg Leu Arg Glu Asn Gln Leu Ser Glu Ser Val Ser Gln Asn 
    290                 295                 300


Lys Ile Leu Leu Gln Arg Ile Glu Asp Ser Asp Leu Ala His Lys Leu 
305                 310                 315                 320


Glu Lys Glu Gln Leu Glu Tyr Ile Ile Val Glu Leu Gln Asp Gln Leu 
                325                 330                 335


Thr Val Leu Lys Asn Asn Asp Leu Arg Ser Arg Gln Glu Leu Thr Ala 
            340                 345                 350


His Leu Thr Asn Gln Trp Pro Ser Pro Gly Ala Leu Asp Val Asn Ala 
        355                 360                 365


Val Ala Leu Asp Thr Leu Leu Tyr Arg Lys His Asn Lys Gln Trp Tyr 
    370                 375                 380


Glu Lys Ser Tyr Gln Ser Leu Asp Gln Leu Ser Ala Glu Val Ser Leu 
385                 390                 395                 400


Ser Gln Thr Ser Leu Asp Pro Gly Gln Ser Gln Glu Gly Asp Gly Lys 
                405                 410                 415


Gln Asp Thr Leu Asn Val Met Ser Glu Gly Lys Glu Asp Thr Pro Ser 
            420                 425                 430


Leu Leu Gly Leu Cys Gly Ser Leu Thr Ser Val Ala Ser Tyr Lys Ser 
        435                 440                 445


Leu Thr Ser Leu Lys Ser Asn Asp Tyr Leu Ala Ser Pro Thr Thr Glu 
    450                 455                 460


Met Thr Ser Pro Gly Leu Thr Pro Ser 
465                 470


<210>  487
<211>  1515
<212>  DNA
<213>  Homo sapiens

<400>  487
tcgcgcctcg ctctggccct gcaggttgtg tttccgcctc taccccgcct ccattccgtt     60

gctctctcag tctcagaccc gggctctcgg tccgccgctt caggtcttgg cgcagcctca    120

gagagttggc gcggctctgt gttgaccaaa cctagtggat gcagttagcg ccggagcccg    180

gccccgcccg tcaccagggt tattcccgcc ttctaggttt gccaggactg ccggccctgc    240

agctgccttc tgccccaggt ttttggctac tgatgttaca aacaataaaa tattggagca    300

tagagttgaa gaacagactc aaaccaggtt tttatttaat tagttaaaaa tatggatcct    360

gagacaaggg gacaagagat tatcaaagtg acacctcttc aacaaatgct tgcctcatgt    420

actggagcta tactgacatc agtaatagtg acacccctgg atgttgttaa aattagactc    480

caagcccaaa acaacccact ccccaaagga aaatgttttg tatatagtaa tggactcatg    540

gatcatctat gtgtctgtga agagggaggc aacaaactat ggtataagaa gccaggaaat    600

ttccagggaa cattggatgc attttttaaa atcattcgaa atgagggcat taaatctcta    660

tggagtggcc ttcctcctac cctagtgatg gcagttcctg ccacagttat ttattttacc    720

tgctatgatc aattaagtgc tcttctgaga tctaagttag gagaaaatga aacctgcata    780

ccaattgttg ctggaattgt agccagattt ggtgcagtaa ctgtgataag tccactagaa    840

ttgattagaa ccaagatgca gtccaagaag ttttcttacg tggaactgca tcgatttgtc    900

agcaagaaag tatctgaaga tggttggatt tccctttgga ggggctgggc tcctactgtt    960

cttagagatg tacctttctc agcaatgtac tggtataact atgaaatttt aaagaagtgg   1020

ttatgtgaga aatctggttt atatgagcca acatttatga tcaactttac ttcaggggca   1080

ttgtctggtt cttttgctgc tgttgcaact ttaccatttg atgtagtaaa aacacaaaag   1140

cagacacaac tttggacata tgaaagtcat aaaatttcta tgcctttgca tatgtcaacc   1200

tggattataa tgaagaacat tgttgctaaa aatggatttt ccggattatt ttcaggccta   1260

attcctcgct taattaaaat tgctcctgct tgtgccatta tgatcagtac atatgaattt   1320

ggaaaggctt ttttccagaa acaaaatgtt cgaaggcagc aatactagtg atgctgtttc   1380

aacttgaaac aacaactata gccaaagaag atggagactc ttaggcaaga atgtttttca   1440

ccattattct ctcacaatga ttttatgtct ttctttccta taatttaaat aaataatttc   1500

agctctacct ctaaa                                                    1515


<210>  488
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  488

Met Asp Pro Glu Thr Arg Gly Gln Glu Ile Ile Lys Val Thr Pro Leu 
1               5                   10                  15


Gln Gln Met Leu Ala Ser Cys Thr Gly Ala Ile Leu Thr Ser Val Ile 
            20                  25                  30


Val Thr Pro Leu Asp Val Val Lys Ile Arg Leu Gln Ala Gln Asn Asn 
        35                  40                  45


Pro Leu Pro Lys Gly Lys Cys Phe Val Tyr Ser Asn Gly Leu Met Asp 
    50                  55                  60


His Leu Cys Val Cys Glu Glu Gly Gly Asn Lys Leu Trp Tyr Lys Lys 
65                  70                  75                  80


Pro Gly Asn Phe Gln Gly Thr Leu Asp Ala Phe Phe Lys Ile Ile Arg 
                85                  90                  95


Asn Glu Gly Ile Lys Ser Leu Trp Ser Gly Leu Pro Pro Thr Leu Val 
            100                 105                 110


Met Ala Val Pro Ala Thr Val Ile Tyr Phe Thr Cys Tyr Asp Gln Leu 
        115                 120                 125


Ser Ala Leu Leu Arg Ser Lys Leu Gly Glu Asn Glu Thr Cys Ile Pro 
    130                 135                 140


Ile Val Ala Gly Ile Val Ala Arg Phe Gly Ala Val Thr Val Ile Ser 
145                 150                 155                 160


Pro Leu Glu Leu Ile Arg Thr Lys Met Gln Ser Lys Lys Phe Ser Tyr 
                165                 170                 175


Val Glu Leu His Arg Phe Val Ser Lys Lys Val Ser Glu Asp Gly Trp 
            180                 185                 190


Ile Ser Leu Trp Arg Gly Trp Ala Pro Thr Val Leu Arg Asp Val Pro 
        195                 200                 205


Phe Ser Ala Met Tyr Trp Tyr Asn Tyr Glu Ile Leu Lys Lys Trp Leu 
    210                 215                 220


Cys Glu Lys Ser Gly Leu Tyr Glu Pro Thr Phe Met Ile Asn Phe Thr 
225                 230                 235                 240


Ser Gly Ala Leu Ser Gly Ser Phe Ala Ala Val Ala Thr Leu Pro Phe 
                245                 250                 255


Asp Val Val Lys Thr Gln Lys Gln Thr Gln Leu Trp Thr Tyr Glu Ser 
            260                 265                 270


His Lys Ile Ser Met Pro Leu His Met Ser Thr Trp Ile Ile Met Lys 
        275                 280                 285


Asn Ile Val Ala Lys Asn Gly Phe Ser Gly Leu Phe Ser Gly Leu Ile 
    290                 295                 300


Pro Arg Leu Ile Lys Ile Ala Pro Ala Cys Ala Ile Met Ile Ser Thr 
305                 310                 315                 320


Tyr Glu Phe Gly Lys Ala Phe Phe Gln Lys Gln Asn Val Arg Arg Gln 
                325                 330                 335


Gln Tyr 



<210>  489
<211>  3923
<212>  DNA
<213>  Homo sapiens

<400>  489
ctctctgagg ctgcgccaag acctgaagcg gcggaccgag agcccgggtc tgagactgag     60

agagcaacgg aatggaggcg gggtagaggc ggaaacacaa cctgcagggc cagagcgagg    120

cgcgagaagg acggcggcgt gagggggcgg ggcgcgcagc gcgagaaggc aggcacgagg    180

ggcgagcgcg aggcggggca cggcgcgtgg cgtgagacgg ggcggggcgc gcgtatcggc    240

gccgcggccg cgtgacgcgt tttcaaatct tcaaccgccg cagcccactc gtttgtgctt    300

tgcgccttcc tcctccgcgc cttggagccg gatccggccc cggaaacccg acctgcagac    360

gcggtacctc tactgcgtag aggccgtagc tggcggaagg agagaggcgg ccgtcctgtc    420

aacaggccgg gggaagccgt gctttcgcgg ctgcccggtg cgacactttc tccggaccca    480

gcatgtaggt gccgggcgac tgccatgaac tccggagcca tgaggatcca cagtaaagga    540

catttccagg gtggaatcca agtcaaaaat gaaaaaaaca gaccatctct gaaatctctg    600

aaaactgata acaggccaga aaaatccaaa tgtaagccac tttggggaaa agtattttac    660

cttgacttac cttctgtcac catatctgaa aaacttcaaa aggacattaa ggatctggga    720

gggcgagttg aagaatttct cagcaaagat atcagttatc ttatttcaaa taagaaggaa    780

gctaaatttg cacaaacctt gggtcgaatt tctcctgtac caagtccaga atctgcatat    840

actgcagaaa ccacttcacc tcatcccagc catgatggaa gttcatttaa gtcaccagac    900

acagtgtgtt taagcagagg aaaattatta gttgaaaaag ctatcaagga ccatgatttt    960

attccttcaa atagtatatt atcaaatgcc ttgtcatggg gagtaaaaat tcttcatatt   1020

gatgacatta gatactacat tgaacaaaag aaaaaagagt tgtatttact caagaaatca   1080

agtacttcag taagagatgg gggcaaaaga gttggtagtg gtgcacaaaa aacaagaaca   1140

ggaagactca aaaagccttt tgtaaaggtg gaagatatga gccaacttta taggccattt   1200

tatcttcagc tgaccaatat gccttttata aattattcta ttcagaagcc ctgcagtcca   1260

tttgatgtag acaagccatc tagtatgcaa aagcaaactc aggttaaact aagaatccaa   1320

acagatggcg ataagtatgg tggaacctca attcaactcc agttgaaaga gaagaagaaa   1380

aaaggatatt gtgaatgttg cttgcagaaa tatgaagatc tagaaactca ccttctaagt   1440

gagcaacaca gaaactttgc acagagtaac cagtatcaag ttgttgatga tattgtatct   1500

aagttagttt ttgactttgt ggaatatgaa aaggacacac ctaaaaagaa aagaataaaa   1560

tacagtgttg gatccctttc tcctgtttct gcaagtgtcc tgaaaaagac tgaacaaaag   1620

gaaaaagtgg aattgcaaca tatttctcag aaagattgcc aggaagatga tacaacagtg   1680

aaggagcaga atttcctgta taaagagacc caggaaactg aaaaaaagct cctgtttatt   1740

tcagagccca tcccccaccc ttcaaatgaa ttgagagggc ttaatgagaa aatgagtaat   1800

aaatgttcca tgttaagtac agctgaagat gacataagac agaattttac acagctacct   1860

ctacataaaa acaaacagga atgcattctt gacatttccg aacacacatt aagtgaaaat   1920

gacttagaag aactaagggt agatcactat aaatgtaaca tacaggcatc tgtacatgtt   1980

tctgatttca gtacagataa tagtggatct caaccaaaac agaagtcaga tactgtgctt   2040

tttccagcaa aggatctcaa ggaaaaggac cttcattcaa tatttactca tgattctggt   2100

ctgataacaa taaacagttc acaagagcac ctaactgttc aggcaaaggc tccattccat   2160

actcctcctg aggaacccaa tgaatgtgac ttcaagaata tggatagttt accttctggt   2220

aaaatacatc gaaaagtgaa aataatatta ggacgaaata gaaaagaaaa tctggaacca   2280

aatgctgaat ttgataaaag aactgaattt attacacaag aagaaaacag aatttgtagt   2340

tcaccggtac agtctttact agacttgttt cagactagtg aagagaaatc agaatttttg   2400

ggtttcacaa gctacacaga aaagagtggt atatgcaatg ttttagatat ttgggaagag   2460

gaaaattcag ataatctgtt aacagcgttt ttctcgtccc cttcaacttc tacatttact   2520

ggcttttaga atttaaaaaa tgcatacttt tcagaagtga taaggatcat attcttgaaa   2580

tttttataaa tatgtatgga aattcttagg atttttttac cagctttgtt tacagaccca   2640

aatgtaaata ttaaaaataa atatttgcaa ttttctacag aattgaatac ctgttaaaga   2700

aaaattacag aataaacttg tgactggtct tgttttacat tatatatatg ttcgtaattg   2760

tttcctgaga attacaatga ataataattt gctttgtcac tgaaaaccac cagtgaagtg   2820

caatttgggg aatatcaaac ttagcattat acatttggat attctagttg tattgtaaat   2880

tttaaaagat tatcaggata acatgacctt gccttgaaaa acctaaattt catacagaaa   2940

ggaaaaatac atttctatgc ttgaattctg gaaatcatca gaaatattga cacttgaggg   3000

tcactggtgg accatgctag tattttggtg ctgagtaatt agattatgta taggggtaac   3060

tggaagccat gaaggaagga cttaaccagg ctaccaagtg gaatataatt tatctgctat   3120

ttttaattac ttaccttgta aataacttta ataatattca aaagttgact ctcctgtggc   3180

tcatgccaca ggatcccagc actttgggag gccgaggcag gctgatcacg aggtcagaag   3240

atcaagacca tcctggccaa catggtgaaa ccttgtctac taaaaataca aaaaattagc   3300

tgggcatggc ggcatgcgcc tgtagtccca gctactccct ccagaggctg agaattgctt   3360

gaacctggga agtgcaggtt gcagtgagcc aagattgtgc cactgtattc cagactgggt   3420

gacagagtga gactccatct caaaaaaaaa aaagttgact ctacccccta atttggtagg   3480

agatgaagga gaaaaggatg gcattgaatt atagatacag ttttgggata tatacaagga   3540

ttgccttgat ctggcactta ctgatacaag catttggaga agagaaaatt caaatataag   3600

aaatttcaat ttgaatctgt ggatataagg catttgcctt tgagtatgtt cttgtaggag   3660

taagactacc accagtgaca ttcaattggt tctattgcat agtacatgaa tctattgtca   3720

ctaaaaatta ggttactaat cttaattttt ttgaaatata tgattctcag tacaggacta   3780

attcatatgc ttttcctgca tacattattt tgatcatttg gataacatca atgaacactg   3840

gctttttaac acctttgttt ttcataccag tacctgaagt aggctcaata aaagagtctt   3900

tacagtgaaa aaaaaaaaaa aaa                                           3923


<210>  490
<211>  674
<212>  PRT
<213>  Homo sapiens

<400>  490

Met Asn Ser Gly Ala Met Arg Ile His Ser Lys Gly His Phe Gln Gly 
1               5                   10                  15


Gly Ile Gln Val Lys Asn Glu Lys Asn Arg Pro Ser Leu Lys Ser Leu 
            20                  25                  30


Lys Thr Asp Asn Arg Pro Glu Lys Ser Lys Cys Lys Pro Leu Trp Gly 
        35                  40                  45


Lys Val Phe Tyr Leu Asp Leu Pro Ser Val Thr Ile Ser Glu Lys Leu 
    50                  55                  60


Gln Lys Asp Ile Lys Asp Leu Gly Gly Arg Val Glu Glu Phe Leu Ser 
65                  70                  75                  80


Lys Asp Ile Ser Tyr Leu Ile Ser Asn Lys Lys Glu Ala Lys Phe Ala 
                85                  90                  95


Gln Thr Leu Gly Arg Ile Ser Pro Val Pro Ser Pro Glu Ser Ala Tyr 
            100                 105                 110


Thr Ala Glu Thr Thr Ser Pro His Pro Ser His Asp Gly Ser Ser Phe 
        115                 120                 125


Lys Ser Pro Asp Thr Val Cys Leu Ser Arg Gly Lys Leu Leu Val Glu 
    130                 135                 140


Lys Ala Ile Lys Asp His Asp Phe Ile Pro Ser Asn Ser Ile Leu Ser 
145                 150                 155                 160


Asn Ala Leu Ser Trp Gly Val Lys Ile Leu His Ile Asp Asp Ile Arg 
                165                 170                 175


Tyr Tyr Ile Glu Gln Lys Lys Lys Glu Leu Tyr Leu Leu Lys Lys Ser 
            180                 185                 190


Ser Thr Ser Val Arg Asp Gly Gly Lys Arg Val Gly Ser Gly Ala Gln 
        195                 200                 205


Lys Thr Arg Thr Gly Arg Leu Lys Lys Pro Phe Val Lys Val Glu Asp 
    210                 215                 220


Met Ser Gln Leu Tyr Arg Pro Phe Tyr Leu Gln Leu Thr Asn Met Pro 
225                 230                 235                 240


Phe Ile Asn Tyr Ser Ile Gln Lys Pro Cys Ser Pro Phe Asp Val Asp 
                245                 250                 255


Lys Pro Ser Ser Met Gln Lys Gln Thr Gln Val Lys Leu Arg Ile Gln 
            260                 265                 270


Thr Asp Gly Asp Lys Tyr Gly Gly Thr Ser Ile Gln Leu Gln Leu Lys 
        275                 280                 285


Glu Lys Lys Lys Lys Gly Tyr Cys Glu Cys Cys Leu Gln Lys Tyr Glu 
    290                 295                 300


Asp Leu Glu Thr His Leu Leu Ser Glu Gln His Arg Asn Phe Ala Gln 
305                 310                 315                 320


Ser Asn Gln Tyr Gln Val Val Asp Asp Ile Val Ser Lys Leu Val Phe 
                325                 330                 335


Asp Phe Val Glu Tyr Glu Lys Asp Thr Pro Lys Lys Lys Arg Ile Lys 
            340                 345                 350


Tyr Ser Val Gly Ser Leu Ser Pro Val Ser Ala Ser Val Leu Lys Lys 
        355                 360                 365


Thr Glu Gln Lys Glu Lys Val Glu Leu Gln His Ile Ser Gln Lys Asp 
    370                 375                 380


Cys Gln Glu Asp Asp Thr Thr Val Lys Glu Gln Asn Phe Leu Tyr Lys 
385                 390                 395                 400


Glu Thr Gln Glu Thr Glu Lys Lys Leu Leu Phe Ile Ser Glu Pro Ile 
                405                 410                 415


Pro His Pro Ser Asn Glu Leu Arg Gly Leu Asn Glu Lys Met Ser Asn 
            420                 425                 430


Lys Cys Ser Met Leu Ser Thr Ala Glu Asp Asp Ile Arg Gln Asn Phe 
        435                 440                 445


Thr Gln Leu Pro Leu His Lys Asn Lys Gln Glu Cys Ile Leu Asp Ile 
    450                 455                 460


Ser Glu His Thr Leu Ser Glu Asn Asp Leu Glu Glu Leu Arg Val Asp 
465                 470                 475                 480


His Tyr Lys Cys Asn Ile Gln Ala Ser Val His Val Ser Asp Phe Ser 
                485                 490                 495


Thr Asp Asn Ser Gly Ser Gln Pro Lys Gln Lys Ser Asp Thr Val Leu 
            500                 505                 510


Phe Pro Ala Lys Asp Leu Lys Glu Lys Asp Leu His Ser Ile Phe Thr 
        515                 520                 525


His Asp Ser Gly Leu Ile Thr Ile Asn Ser Ser Gln Glu His Leu Thr 
    530                 535                 540


Val Gln Ala Lys Ala Pro Phe His Thr Pro Pro Glu Glu Pro Asn Glu 
545                 550                 555                 560


Cys Asp Phe Lys Asn Met Asp Ser Leu Pro Ser Gly Lys Ile His Arg 
                565                 570                 575


Lys Val Lys Ile Ile Leu Gly Arg Asn Arg Lys Glu Asn Leu Glu Pro 
            580                 585                 590


Asn Ala Glu Phe Asp Lys Arg Thr Glu Phe Ile Thr Gln Glu Glu Asn 
        595                 600                 605


Arg Ile Cys Ser Ser Pro Val Gln Ser Leu Leu Asp Leu Phe Gln Thr 
    610                 615                 620


Ser Glu Glu Lys Ser Glu Phe Leu Gly Phe Thr Ser Tyr Thr Glu Lys 
625                 630                 635                 640


Ser Gly Ile Cys Asn Val Leu Asp Ile Trp Glu Glu Glu Asn Ser Asp 
                645                 650                 655


Asn Leu Leu Thr Ala Phe Phe Ser Ser Pro Ser Thr Ser Thr Phe Thr 
            660                 665                 670


Gly Phe 



<210>  491
<211>  2744
<212>  DNA
<213>  Homo sapiens

<400>  491
gcggagcgag ggaaacggac tcggcggcgc cggcatgagg agctgagcgt ctcgggcgag     60

gcgggctgac ggcagcacca tgcaggcggc agtggctgtg tccgtgccct tcttgctgct    120

ctgtgtcctg gggacctgcc ctccggcgcg ctgcggccag gcaggagacg cctcattgat    180

ggagctagag aagaggaagg aaaaccgctt cgtggagcgc cagagcatcg tgccactgcg    240

cctcatctac cgctcgggcg gcgaagacga aagtcggcac gacgcgctcg acacgcgggt    300

gcggggcgac ctcggtggcc cgcagttgac tcatgttgac caagcaagct tccaggttga    360

tgcctttgga acgtcattca ttctcgatgt cgtgctaaat catgatttgc tgtcctctga    420

atacatagag agacacattg aacatggagg caagactgtg gaagttaaag gaggagagca    480

ctgttactac cagggccata tccgaggaaa ccctgactca tttgttgcat tgtcaacatg    540

ccacggactt catgggatgt tctatgacgg gaaccacaca tatctcattg agccagaaga    600

aaatgacact actcaagagg atttccattt tcattcagtt tacaaatcca gactgtttga    660

attttccttg gatgatcttc catctgaatt tcagcaagta aacattactc catcaaaatt    720

tattttgaag ccaagaccaa aaaggagtaa acggcagctt cgtcgatatc ctcgtaatgt    780

agaagaagaa accaaataca ttgaactgat gattgtgaat gatcacctta tgtttaaaaa    840

acatcggctt tccgttgtac ataccaatac ctatgcgaaa tctgtggtga acatggcaga    900

tttaatatat aaagaccaac ttaagaccag gatagtattg gttgctatgg aaacctgggc    960

gactgacaac aagtttgcca tatctgaaaa tccattgatc accctacgtg agtttatgaa   1020

atacaggagg gattttatca aagagaaaag tgatgcagtt cacctttttt cgggaagtca   1080

atttgagagt agccggagcg gggcagctta tattggtggg atttgctcgt tgctgaaagg   1140

aggaggcgtg aatgaatttg ggaaaactga tttaatggct gttacacttg cccagtcatt   1200

agcccataat attggtatta tctcagacaa aagaaagtta gcaagtggtg aatgtaaatg   1260

cgaggacacg tggtccgggt gcataatggg agacactggc tattatcttc ctaaaaagtt   1320

cacccagtgt aatattgaag agtatcatga cttcctgaat agtggaggtg gtgcctgcct   1380

tttcaacaaa ccttctaagc ttcttgatcc tcctgagtgt ggcaatggct tcattgaaac   1440

tggagaggag tgtgattgtg gaaccccggc cgaatgtgtc cttgaaggag cagagtgttg   1500

taagaaatgc accttgactc aagactctca atgcagtgac ggtctttgct gtaaaaagtg   1560

caagtttcag cctatgggca ctgtgtgccg agaagcagta aatgattgtg atattcgtga   1620

aacgtgctca ggaaattcaa gccagtgtgc ccctaatatt cataaaatgg atggatattc   1680

atgtgatggt gttcagggaa tttgctttgg aggaagatgc aaaaccagag atagacaatg   1740

caaatacatt tgggggcaaa aggtgacagc atcagacaaa tattgctatg agaaactgaa   1800

tattgaaggg acggagaagg gtaactgtgg gaaagacaaa gacacatgga tacagtgcaa   1860

caaacgggat gtgctttgtg gttacctttt gtgtaccaat attggcaata tcccaaggct   1920

tggagaactc gatggtgaaa tcacatctac tttagttgtg cagcaaggaa gaacattaaa   1980

ctgcagtggt gggcatgtta agcttgaaga agatgtagat cttggctatg tggaagatgg   2040

gacaccttgt ggtccccaaa tgatgtgctt agaacacagg tgtcttcctg tggcttcttt   2100

caactttagt acttgcttga gcagtaaaga aggcactatt tgctcaggaa atggagtttg   2160

cagtaatgag ctgaagtgtg tgtgtaacag acactggata ggttctgatt gcaacactta   2220

cttccctcac aatgatgatg caaagactgg tatcactctg tctggcaatg gtgttgctgg   2280

caccaatatc ataataggca taattgctgg caccatttta gtgctggccc tcatattagg   2340

aataactgcg tggggttata aaaactatcg agaacagaga cagttacccc agggagatta   2400

tgtaaaaaag cctggagatg gtgactcttt ttatagcgac attcctcccg gagtcagcac   2460

aaactcagca tctagttcta agaagaggtc aaatgggctc tctcattctt ggagtgaaag   2520

gattccagac acaaaacata tttcagacat ctgtgaaaat gggcgacctc gaagtaactc   2580

ttggcaaggt aacctgggag gcaacaaaaa gaaaatcaga ggcaaaagat ttagacctcg   2640

gtctaattca actgagtaag tctgaacctc taatggaaaa aggcactcca aggtcctgtg   2700

caaatagtgt caaaagtaaa ttaagcagat agtcaaagaa ctgt                    2744


<210>  492
<211>  859
<212>  PRT
<213>  Homo sapiens

<400>  492

Met Gln Ala Ala Val Ala Val Ser Val Pro Phe Leu Leu Leu Cys Val 
1               5                   10                  15


Leu Gly Thr Cys Pro Pro Ala Arg Cys Gly Gln Ala Gly Asp Ala Ser 
            20                  25                  30


Leu Met Glu Leu Glu Lys Arg Lys Glu Asn Arg Phe Val Glu Arg Gln 
        35                  40                  45


Ser Ile Val Pro Leu Arg Leu Ile Tyr Arg Ser Gly Gly Glu Asp Glu 
    50                  55                  60


Ser Arg His Asp Ala Leu Asp Thr Arg Val Arg Gly Asp Leu Gly Gly 
65                  70                  75                  80


Pro Gln Leu Thr His Val Asp Gln Ala Ser Phe Gln Val Asp Ala Phe 
                85                  90                  95


Gly Thr Ser Phe Ile Leu Asp Val Val Leu Asn His Asp Leu Leu Ser 
            100                 105                 110


Ser Glu Tyr Ile Glu Arg His Ile Glu His Gly Gly Lys Thr Val Glu 
        115                 120                 125


Val Lys Gly Gly Glu His Cys Tyr Tyr Gln Gly His Ile Arg Gly Asn 
    130                 135                 140


Pro Asp Ser Phe Val Ala Leu Ser Thr Cys His Gly Leu His Gly Met 
145                 150                 155                 160


Phe Tyr Asp Gly Asn His Thr Tyr Leu Ile Glu Pro Glu Glu Asn Asp 
                165                 170                 175


Thr Thr Gln Glu Asp Phe His Phe His Ser Val Tyr Lys Ser Arg Leu 
            180                 185                 190


Phe Glu Phe Ser Leu Asp Asp Leu Pro Ser Glu Phe Gln Gln Val Asn 
        195                 200                 205


Ile Thr Pro Ser Lys Phe Ile Leu Lys Pro Arg Pro Lys Arg Ser Lys 
    210                 215                 220


Arg Gln Leu Arg Arg Tyr Pro Arg Asn Val Glu Glu Glu Thr Lys Tyr 
225                 230                 235                 240


Ile Glu Leu Met Ile Val Asn Asp His Leu Met Phe Lys Lys His Arg 
                245                 250                 255


Leu Ser Val Val His Thr Asn Thr Tyr Ala Lys Ser Val Val Asn Met 
            260                 265                 270


Ala Asp Leu Ile Tyr Lys Asp Gln Leu Lys Thr Arg Ile Val Leu Val 
        275                 280                 285


Ala Met Glu Thr Trp Ala Thr Asp Asn Lys Phe Ala Ile Ser Glu Asn 
    290                 295                 300


Pro Leu Ile Thr Leu Arg Glu Phe Met Lys Tyr Arg Arg Asp Phe Ile 
305                 310                 315                 320


Lys Glu Lys Ser Asp Ala Val His Leu Phe Ser Gly Ser Gln Phe Glu 
                325                 330                 335


Ser Ser Arg Ser Gly Ala Ala Tyr Ile Gly Gly Ile Cys Ser Leu Leu 
            340                 345                 350


Lys Gly Gly Gly Val Asn Glu Phe Gly Lys Thr Asp Leu Met Ala Val 
        355                 360                 365


Thr Leu Ala Gln Ser Leu Ala His Asn Ile Gly Ile Ile Ser Asp Lys 
    370                 375                 380


Arg Lys Leu Ala Ser Gly Glu Cys Lys Cys Glu Asp Thr Trp Ser Gly 
385                 390                 395                 400


Cys Ile Met Gly Asp Thr Gly Tyr Tyr Leu Pro Lys Lys Phe Thr Gln 
                405                 410                 415


Cys Asn Ile Glu Glu Tyr His Asp Phe Leu Asn Ser Gly Gly Gly Ala 
            420                 425                 430


Cys Leu Phe Asn Lys Pro Ser Lys Leu Leu Asp Pro Pro Glu Cys Gly 
        435                 440                 445


Asn Gly Phe Ile Glu Thr Gly Glu Glu Cys Asp Cys Gly Thr Pro Ala 
    450                 455                 460


Glu Cys Val Leu Glu Gly Ala Glu Cys Cys Lys Lys Cys Thr Leu Thr 
465                 470                 475                 480


Gln Asp Ser Gln Cys Ser Asp Gly Leu Cys Cys Lys Lys Cys Lys Phe 
                485                 490                 495


Gln Pro Met Gly Thr Val Cys Arg Glu Ala Val Asn Asp Cys Asp Ile 
            500                 505                 510


Arg Glu Thr Cys Ser Gly Asn Ser Ser Gln Cys Ala Pro Asn Ile His 
        515                 520                 525


Lys Met Asp Gly Tyr Ser Cys Asp Gly Val Gln Gly Ile Cys Phe Gly 
    530                 535                 540


Gly Arg Cys Lys Thr Arg Asp Arg Gln Cys Lys Tyr Ile Trp Gly Gln 
545                 550                 555                 560


Lys Val Thr Ala Ser Asp Lys Tyr Cys Tyr Glu Lys Leu Asn Ile Glu 
                565                 570                 575


Gly Thr Glu Lys Gly Asn Cys Gly Lys Asp Lys Asp Thr Trp Ile Gln 
            580                 585                 590


Cys Asn Lys Arg Asp Val Leu Cys Gly Tyr Leu Leu Cys Thr Asn Ile 
        595                 600                 605


Gly Asn Ile Pro Arg Leu Gly Glu Leu Asp Gly Glu Ile Thr Ser Thr 
    610                 615                 620


Leu Val Val Gln Gln Gly Arg Thr Leu Asn Cys Ser Gly Gly His Val 
625                 630                 635                 640


Lys Leu Glu Glu Asp Val Asp Leu Gly Tyr Val Glu Asp Gly Thr Pro 
                645                 650                 655


Cys Gly Pro Gln Met Met Cys Leu Glu His Arg Cys Leu Pro Val Ala 
            660                 665                 670


Ser Phe Asn Phe Ser Thr Cys Leu Ser Ser Lys Glu Gly Thr Ile Cys 
        675                 680                 685


Ser Gly Asn Gly Val Cys Ser Asn Glu Leu Lys Cys Val Cys Asn Arg 
    690                 695                 700


His Trp Ile Gly Ser Asp Cys Asn Thr Tyr Phe Pro His Asn Asp Asp 
705                 710                 715                 720


Ala Lys Thr Gly Ile Thr Leu Ser Gly Asn Gly Val Ala Gly Thr Asn 
                725                 730                 735


Ile Ile Ile Gly Ile Ile Ala Gly Thr Ile Leu Val Leu Ala Leu Ile 
            740                 745                 750


Leu Gly Ile Thr Ala Trp Gly Tyr Lys Asn Tyr Arg Glu Gln Arg Gln 
        755                 760                 765


Leu Pro Gln Gly Asp Tyr Val Lys Lys Pro Gly Asp Gly Asp Ser Phe 
    770                 775                 780


Tyr Ser Asp Ile Pro Pro Gly Val Ser Thr Asn Ser Ala Ser Ser Ser 
785                 790                 795                 800


Lys Lys Arg Ser Asn Gly Leu Ser His Ser Trp Ser Glu Arg Ile Pro 
                805                 810                 815


Asp Thr Lys His Ile Ser Asp Ile Cys Glu Asn Gly Arg Pro Arg Ser 
            820                 825                 830


Asn Ser Trp Gln Gly Asn Leu Gly Gly Asn Lys Lys Lys Ile Arg Gly 
        835                 840                 845


Lys Arg Phe Arg Pro Arg Ser Asn Ser Thr Glu 
    850                 855


<210>  493
<211>  3347
<212>  DNA
<213>  Homo sapiens

<400>  493
gcggagcgag ggaaacggac tcggcggcgc cggcatgagg agctgagcgt ctcgggcgag     60

gcgggctgac ggcagcacca tgcaggcggc agtggctgtg tccgtgccct tcttgctgct    120

ctgtgtcctg gggacctgcc ctccggcgcg ctgcggccag gcaggagacg cctcattgat    180

ggagctagag aagaggaagg aaaaccgctt cgtggagcgc cagagcatcg tgccactgcg    240

cctcatctac cgctcgggcg gcgaagacga aagtcggcac gacgcgctcg acacgcgggt    300

gcggggcgac ctcggtggcc cgcagttgac tcatgttgac caagcaagct tccaggttga    360

tgcctttgga acgtcattca ttctcgatgt cgtgctaaat catgatttgc tgtcctctga    420

atacatagag agacacattg aacatggagg caagactgtg gaagttaaag gaggagagca    480

ctgttactac cagggccata tccgaggaaa ccctgactca tttgttgcat tgtcaacatg    540

ccacggactt catgggatgt tctatgacgg gaaccacaca tatctcattg agccagaaga    600

aaatgacact actcaagagg atttccattt tcattcagtt tacaaatcca gactgtttga    660

attttccttg gatgatcttc catctgaatt tcagcaagta aacattactc catcaaaatt    720

tattttgaag ccaagaccaa aaaggagtaa acggcagctt cgtcgatatc ctcgtaatgt    780

agaagaagaa accaaataca ttgaactgat gattgtgaat gatcacctta tgtttaaaaa    840

acatcggctt tccgttgtac ataccaatac ctatgcgaaa tctgtggtga acatggcaga    900

tttaatatat aaagaccaac ttaagaccag gatagtattg gttgctatgg aaacctgggc    960

gactgacaac aagtttgcca tatctgaaaa tccattgatc accctacgtg agtttatgaa   1020

atacaggagg gattttatca aagagaaaag tgatgcagtt cacctttttt cgggaagtca   1080

atttgagagt agccggagcg gggcagctta tattggtggg atttgctcgt tgctgaaagg   1140

aggaggcgtg aatgaatttg ggaaaactga tttaatggct gttacacttg cccagtcatt   1200

agcccataat attggtatta tctcagacaa aagaaagtta gcaagtggtg aatgtaaatg   1260

cgaggacacg tggtccgggt gcataatggg agacactggc tattatcttc ctaaaaagtt   1320

cacccagtgt aatattgaag agtatcatga cttcctgaat agtggaggtg gtgcctgcct   1380

tttcaacaaa ccttctaagc ttcttgatcc tcctgagtgt ggcaatggct tcattgaaac   1440

tggagaggag tgtgattgtg gaaccccggc cgaatgtgtc cttgaaggag cagagtgttg   1500

taagaaatgc accttgactc aagactctca atgcagtgac ggtctttgct gtaaaaagtg   1560

caagtttcag cctatgggca ctgtgtgccg agaagcagta aatgattgtg atattcgtga   1620

aacgtgctca ggaaattcaa gccagtgtgc ccctaatatt cataaaatgg atggatattc   1680

atgtgatggt gttcagggaa tttgctttgg aggaagatgc aaaaccagag atagacaatg   1740

caaatacatt tgggggcaaa aggtgacagc atcagacaaa tattgctatg agaaactgaa   1800

tattgaaggg acggagaagg gtaactgtgg gaaagacaaa gacacatgga tacagtgcaa   1860

caaacgggat gtgctttgtg gttacctttt gtgtaccaat attggcaata tcccaaggct   1920

tggagaactc gatggtgaaa tcacatctac tttagttgtg cagcaaggaa gaacattaaa   1980

ctgcagtggt gggcatgtta agcttgaaga agatgtagat cttggctatg tggaagatgg   2040

gacaccttgt ggtccccaaa tgatgtgctt agaacacagg tgtcttcctg tggcttcttt   2100

caactttagt acttgcttga gcagtaaaga aggcactatt tgctcaggaa atggagtttg   2160

cagtaatgag ctgaagtgtg tgtgtaacag acactggata ggttctgatt gcaacactta   2220

cttccctcac aatgatgatg caaagactgg tatcactctg tctggcaatg gtgttgctgg   2280

caccaatatc ataataggca taattgctgg caccatttta gtgctggccc tcatattagg   2340

aataactgcg tggggttata aaaactatcg agaacagagg tcaaatgggc tctctcattc   2400

ttggagtgaa aggattccag acacaaaaca tatttcagac atctgtgaaa atgggcgacc   2460

tcgaagtaac tcttggcaag gtaacctggg aggcaacaaa aagaaaatca gaggcaaaag   2520

atttagacct cggtctaatt caactgagac tttatctcct gccaagtctc cttcttcatc   2580

aactgggtct attgcctcca gcagaaaata cccttaccca atgcctccac ttcctgatga   2640

ggacaagaaa gtgaaccgac aaagtgccag gctatgggag acatccattt aagatcaact   2700

gtttacatgt gatacatcga aaactgttta cttcaacttt tatagaaacc caggctcatg   2760

gaatcactgc aaatctatct gctcttcaga caatacgaag accctctgag atgctacaga   2820

ggagaggaag cggagtttca catctggtta ccattttctt tttgtcattg gcttaggatt   2880

taactaacca tgaaaagaac tactgaaata ttacactata acatggaaca ataaaggtac   2940

tggtatgtta atggataatc cgcatgacag ataatatgta gaaatattca taaagttaac   3000

tcacatgacc caaatgtagc aagtttccta aggtacaata gtggattcag aacttgacgt   3060

tctgaggcac atcctcactg taaacagtaa tgctatatgc atgaagcttc tgtttattgt   3120

tttccatatt taaggaaaca acatcccata atagaaatga gcatgcaggg ctaaggcata   3180

taggattttt ctgcaggact ttaaagcttt gaaaggccaa tatcccatag gctaacttta   3240

aacatgtatt tttatttttg ttttgttttt tacttttcat atttatatta gcatacaagg   3300

acaattgtat atatgtaaca tttttaaaat tttaaaaaaa aaaaaaa                 3347


<210>  494
<211>  870
<212>  PRT
<213>  Homo sapiens

<400>  494

Met Gln Ala Ala Val Ala Val Ser Val Pro Phe Leu Leu Leu Cys Val 
1               5                   10                  15


Leu Gly Thr Cys Pro Pro Ala Arg Cys Gly Gln Ala Gly Asp Ala Ser 
            20                  25                  30


Leu Met Glu Leu Glu Lys Arg Lys Glu Asn Arg Phe Val Glu Arg Gln 
        35                  40                  45


Ser Ile Val Pro Leu Arg Leu Ile Tyr Arg Ser Gly Gly Glu Asp Glu 
    50                  55                  60


Ser Arg His Asp Ala Leu Asp Thr Arg Val Arg Gly Asp Leu Gly Gly 
65                  70                  75                  80


Pro Gln Leu Thr His Val Asp Gln Ala Ser Phe Gln Val Asp Ala Phe 
                85                  90                  95


Gly Thr Ser Phe Ile Leu Asp Val Val Leu Asn His Asp Leu Leu Ser 
            100                 105                 110


Ser Glu Tyr Ile Glu Arg His Ile Glu His Gly Gly Lys Thr Val Glu 
        115                 120                 125


Val Lys Gly Gly Glu His Cys Tyr Tyr Gln Gly His Ile Arg Gly Asn 
    130                 135                 140


Pro Asp Ser Phe Val Ala Leu Ser Thr Cys His Gly Leu His Gly Met 
145                 150                 155                 160


Phe Tyr Asp Gly Asn His Thr Tyr Leu Ile Glu Pro Glu Glu Asn Asp 
                165                 170                 175


Thr Thr Gln Glu Asp Phe His Phe His Ser Val Tyr Lys Ser Arg Leu 
            180                 185                 190


Phe Glu Phe Ser Leu Asp Asp Leu Pro Ser Glu Phe Gln Gln Val Asn 
        195                 200                 205


Ile Thr Pro Ser Lys Phe Ile Leu Lys Pro Arg Pro Lys Arg Ser Lys 
    210                 215                 220


Arg Gln Leu Arg Arg Tyr Pro Arg Asn Val Glu Glu Glu Thr Lys Tyr 
225                 230                 235                 240


Ile Glu Leu Met Ile Val Asn Asp His Leu Met Phe Lys Lys His Arg 
                245                 250                 255


Leu Ser Val Val His Thr Asn Thr Tyr Ala Lys Ser Val Val Asn Met 
            260                 265                 270


Ala Asp Leu Ile Tyr Lys Asp Gln Leu Lys Thr Arg Ile Val Leu Val 
        275                 280                 285


Ala Met Glu Thr Trp Ala Thr Asp Asn Lys Phe Ala Ile Ser Glu Asn 
    290                 295                 300


Pro Leu Ile Thr Leu Arg Glu Phe Met Lys Tyr Arg Arg Asp Phe Ile 
305                 310                 315                 320


Lys Glu Lys Ser Asp Ala Val His Leu Phe Ser Gly Ser Gln Phe Glu 
                325                 330                 335


Ser Ser Arg Ser Gly Ala Ala Tyr Ile Gly Gly Ile Cys Ser Leu Leu 
            340                 345                 350


Lys Gly Gly Gly Val Asn Glu Phe Gly Lys Thr Asp Leu Met Ala Val 
        355                 360                 365


Thr Leu Ala Gln Ser Leu Ala His Asn Ile Gly Ile Ile Ser Asp Lys 
    370                 375                 380


Arg Lys Leu Ala Ser Gly Glu Cys Lys Cys Glu Asp Thr Trp Ser Gly 
385                 390                 395                 400


Cys Ile Met Gly Asp Thr Gly Tyr Tyr Leu Pro Lys Lys Phe Thr Gln 
                405                 410                 415


Cys Asn Ile Glu Glu Tyr His Asp Phe Leu Asn Ser Gly Gly Gly Ala 
            420                 425                 430


Cys Leu Phe Asn Lys Pro Ser Lys Leu Leu Asp Pro Pro Glu Cys Gly 
        435                 440                 445


Asn Gly Phe Ile Glu Thr Gly Glu Glu Cys Asp Cys Gly Thr Pro Ala 
    450                 455                 460


Glu Cys Val Leu Glu Gly Ala Glu Cys Cys Lys Lys Cys Thr Leu Thr 
465                 470                 475                 480


Gln Asp Ser Gln Cys Ser Asp Gly Leu Cys Cys Lys Lys Cys Lys Phe 
                485                 490                 495


Gln Pro Met Gly Thr Val Cys Arg Glu Ala Val Asn Asp Cys Asp Ile 
            500                 505                 510


Arg Glu Thr Cys Ser Gly Asn Ser Ser Gln Cys Ala Pro Asn Ile His 
        515                 520                 525


Lys Met Asp Gly Tyr Ser Cys Asp Gly Val Gln Gly Ile Cys Phe Gly 
    530                 535                 540


Gly Arg Cys Lys Thr Arg Asp Arg Gln Cys Lys Tyr Ile Trp Gly Gln 
545                 550                 555                 560


Lys Val Thr Ala Ser Asp Lys Tyr Cys Tyr Glu Lys Leu Asn Ile Glu 
                565                 570                 575


Gly Thr Glu Lys Gly Asn Cys Gly Lys Asp Lys Asp Thr Trp Ile Gln 
            580                 585                 590


Cys Asn Lys Arg Asp Val Leu Cys Gly Tyr Leu Leu Cys Thr Asn Ile 
        595                 600                 605


Gly Asn Ile Pro Arg Leu Gly Glu Leu Asp Gly Glu Ile Thr Ser Thr 
    610                 615                 620


Leu Val Val Gln Gln Gly Arg Thr Leu Asn Cys Ser Gly Gly His Val 
625                 630                 635                 640


Lys Leu Glu Glu Asp Val Asp Leu Gly Tyr Val Glu Asp Gly Thr Pro 
                645                 650                 655


Cys Gly Pro Gln Met Met Cys Leu Glu His Arg Cys Leu Pro Val Ala 
            660                 665                 670


Ser Phe Asn Phe Ser Thr Cys Leu Ser Ser Lys Glu Gly Thr Ile Cys 
        675                 680                 685


Ser Gly Asn Gly Val Cys Ser Asn Glu Leu Lys Cys Val Cys Asn Arg 
    690                 695                 700


His Trp Ile Gly Ser Asp Cys Asn Thr Tyr Phe Pro His Asn Asp Asp 
705                 710                 715                 720


Ala Lys Thr Gly Ile Thr Leu Ser Gly Asn Gly Val Ala Gly Thr Asn 
                725                 730                 735


Ile Ile Ile Gly Ile Ile Ala Gly Thr Ile Leu Val Leu Ala Leu Ile 
            740                 745                 750


Leu Gly Ile Thr Ala Trp Gly Tyr Lys Asn Tyr Arg Glu Gln Arg Ser 
        755                 760                 765


Asn Gly Leu Ser His Ser Trp Ser Glu Arg Ile Pro Asp Thr Lys His 
    770                 775                 780


Ile Ser Asp Ile Cys Glu Asn Gly Arg Pro Arg Ser Asn Ser Trp Gln 
785                 790                 795                 800


Gly Asn Leu Gly Gly Asn Lys Lys Lys Ile Arg Gly Lys Arg Phe Arg 
                805                 810                 815


Pro Arg Ser Asn Ser Thr Glu Thr Leu Ser Pro Ala Lys Ser Pro Ser 
            820                 825                 830


Ser Ser Thr Gly Ser Ile Ala Ser Ser Arg Lys Tyr Pro Tyr Pro Met 
        835                 840                 845


Pro Pro Leu Pro Asp Glu Asp Lys Lys Val Asn Arg Gln Ser Ala Arg 
    850                 855                 860


Leu Trp Glu Thr Ser Ile 
865                 870


<210>  495
<211>  2636
<212>  DNA
<213>  Homo sapiens

<400>  495
gcggagcgag ggaaacggac tcggcggcgc cggcatgagg agctgagcgt ctcgggcgag     60

gcgggctgac ggcagcacca tgcaggcggc agtggctgtg tccgtgccct tcttgctgct    120

ctgtgtcctg gggacctgcc ctccggcgcg ctgcggccag gcaggagacg cctcattgat    180

ggagctagag aagaggaagg aaaaccgctt cgtggagcgc cagagcatcg tgccactgcg    240

cctcatctac cgctcgggcg gcgaagacga aagtcggcac gacgcgctcg acacgcgggt    300

gcggggcgac ctcggtggcc cgcagttgac tcatgttgac caagcaagct tccaggttga    360

tgcctttgga acgtcattca ttctcgatgt cgtgctaaat catgatttgc tgtcctctga    420

atacatagag agacacattg aacatggagg caagactgtg gaagttaaag gaggagagca    480

ctgttactac cagggccata tccgaggaaa ccctgactca tttgttgcat tgtcaacatg    540

ccacggactt catgggatgt tctatgacgg gaaccacaca tatctcattg agccagaaga    600

aaatgacact actcaagagg atttccattt tcattcagtt tacaaatcca gactgtttga    660

attttccttg gatgatcttc catctgaatt tcagcaagta aacattactc catcaaaatt    720

tattttgaag ccaagaccaa aaaggagtaa acggcagctt cgtcgatatc ctcgtaatgt    780

agaagaagaa accaaataca ttgaactgat gattgtgaat gatcacctta tgtttaaaaa    840

acatcggctt tccgttgtac ataccaatac ctatgcgaaa tctgtggtga acatggcaga    900

tttaatatat aaagaccaac ttaagaccag gatagtattg gttgctatgg aaacctgggc    960

gactgacaac aagtttgcca tatctgaaaa tccattgatc accctacgtg agtttatgaa   1020

atacaggagg gattttatca aagagaaaag tgatgcagtt cacctttttt cgggaagtca   1080

atttgagagt agccggagcg gggcagctta tattggtggg atttgctcgt tgctgaaagg   1140

aggaggcgtg aatgaatttg ggaaaactga tttaatggct gttacacttg cccagtcatt   1200

agcccataat attggtatta tctcagacaa aagaaagtta gcaagtggtg aatgtaaatg   1260

cgaggacacg tggtccgggt gcataatggg agacactggc tattatcttc ctaaaaagtt   1320

cacccagtgt aatattgaag agtatcatga cttcctgaat agtggaggtg gtgcctgcct   1380

tttcaacaaa ccttctaagc ttcttgatcc tcctgagtgt ggcaatggct tcattgaaac   1440

tggagaggag tgtgattgtg gaaccccggc cgaatgtgtc cttgaaggag cagagtgttg   1500

taagaaatgc accttgactc aagactctca atgcagtgac ggtctttgct gtaaaaagtg   1560

caagtttcag cctatgggca ctgtgtgccg agaagcagta aatgattgtg atattcgtga   1620

aacgtgctca ggaaattcaa gccagtgtgc ccctaatatt cataaaatgg atggatattc   1680

atgtgatggt gttcagggaa tttgctttgg aggaagatgc aaaaccagag atagacaatg   1740

caaatacatt tgggggcaaa aggtgacagc atcagacaaa tattgctatg agaaactgaa   1800

tattgaaggg acggagaagg gtaactgtgg gaaagacaaa gacacatgga tacagtgcaa   1860

caaacgggat gtgctttgtg gttacctttt gtgtaccaat attggcaata tcccaaggct   1920

tggagaactc gatggtgaaa tcacatctac tttagttgtg cagcaaggaa gaacattaaa   1980

ctgcagtggt gggcatgtta agcttgaaga agatgtagat cttggctatg tggaagatgg   2040

gacaccttgt ggtccccaaa tgatgtgctt agaacacagg tgtcttcctg tggcttcttt   2100

caactttagt acttgcttga gcagtaaaga aggcactatt tgctcaggaa atggagtttg   2160

cagtaatgag ctgaagtgtg tgtgtaacag acactggata ggttctgatt gcaacactta   2220

cttccctcac aatgatgatg caaagactgg tatcactctg tctggcaatg gtgttgctgg   2280

caccaatatc ataataggca taattgctgg caccatttta gtgctggccc tcatattagg   2340

aataactgcg tggggttata aaaactatcg agaacagagg tcaaatgggc tctctcattc   2400

ttggagtgaa aggattccag acacaaaaca tatttcagac atctgtgaaa atgggcgacc   2460

tcgaagtaac tcttggcaag gtaacctggg aggcaacaaa aagaaaatca gaggcaaaag   2520

atttagacct cggtctaatt caactgagta agtctgaacc tctaatggaa aaaggcactc   2580

caaggtcctg tgcaaatagt gtcaaaagta aattaagcag atagtcaaag aactgt       2636


<210>  496
<211>  823
<212>  PRT
<213>  Homo sapiens

<400>  496

Met Gln Ala Ala Val Ala Val Ser Val Pro Phe Leu Leu Leu Cys Val 
1               5                   10                  15


Leu Gly Thr Cys Pro Pro Ala Arg Cys Gly Gln Ala Gly Asp Ala Ser 
            20                  25                  30


Leu Met Glu Leu Glu Lys Arg Lys Glu Asn Arg Phe Val Glu Arg Gln 
        35                  40                  45


Ser Ile Val Pro Leu Arg Leu Ile Tyr Arg Ser Gly Gly Glu Asp Glu 
    50                  55                  60


Ser Arg His Asp Ala Leu Asp Thr Arg Val Arg Gly Asp Leu Gly Gly 
65                  70                  75                  80


Pro Gln Leu Thr His Val Asp Gln Ala Ser Phe Gln Val Asp Ala Phe 
                85                  90                  95


Gly Thr Ser Phe Ile Leu Asp Val Val Leu Asn His Asp Leu Leu Ser 
            100                 105                 110


Ser Glu Tyr Ile Glu Arg His Ile Glu His Gly Gly Lys Thr Val Glu 
        115                 120                 125


Val Lys Gly Gly Glu His Cys Tyr Tyr Gln Gly His Ile Arg Gly Asn 
    130                 135                 140


Pro Asp Ser Phe Val Ala Leu Ser Thr Cys His Gly Leu His Gly Met 
145                 150                 155                 160


Phe Tyr Asp Gly Asn His Thr Tyr Leu Ile Glu Pro Glu Glu Asn Asp 
                165                 170                 175


Thr Thr Gln Glu Asp Phe His Phe His Ser Val Tyr Lys Ser Arg Leu 
            180                 185                 190


Phe Glu Phe Ser Leu Asp Asp Leu Pro Ser Glu Phe Gln Gln Val Asn 
        195                 200                 205


Ile Thr Pro Ser Lys Phe Ile Leu Lys Pro Arg Pro Lys Arg Ser Lys 
    210                 215                 220


Arg Gln Leu Arg Arg Tyr Pro Arg Asn Val Glu Glu Glu Thr Lys Tyr 
225                 230                 235                 240


Ile Glu Leu Met Ile Val Asn Asp His Leu Met Phe Lys Lys His Arg 
                245                 250                 255


Leu Ser Val Val His Thr Asn Thr Tyr Ala Lys Ser Val Val Asn Met 
            260                 265                 270


Ala Asp Leu Ile Tyr Lys Asp Gln Leu Lys Thr Arg Ile Val Leu Val 
        275                 280                 285


Ala Met Glu Thr Trp Ala Thr Asp Asn Lys Phe Ala Ile Ser Glu Asn 
    290                 295                 300


Pro Leu Ile Thr Leu Arg Glu Phe Met Lys Tyr Arg Arg Asp Phe Ile 
305                 310                 315                 320


Lys Glu Lys Ser Asp Ala Val His Leu Phe Ser Gly Ser Gln Phe Glu 
                325                 330                 335


Ser Ser Arg Ser Gly Ala Ala Tyr Ile Gly Gly Ile Cys Ser Leu Leu 
            340                 345                 350


Lys Gly Gly Gly Val Asn Glu Phe Gly Lys Thr Asp Leu Met Ala Val 
        355                 360                 365


Thr Leu Ala Gln Ser Leu Ala His Asn Ile Gly Ile Ile Ser Asp Lys 
    370                 375                 380


Arg Lys Leu Ala Ser Gly Glu Cys Lys Cys Glu Asp Thr Trp Ser Gly 
385                 390                 395                 400


Cys Ile Met Gly Asp Thr Gly Tyr Tyr Leu Pro Lys Lys Phe Thr Gln 
                405                 410                 415


Cys Asn Ile Glu Glu Tyr His Asp Phe Leu Asn Ser Gly Gly Gly Ala 
            420                 425                 430


Cys Leu Phe Asn Lys Pro Ser Lys Leu Leu Asp Pro Pro Glu Cys Gly 
        435                 440                 445


Asn Gly Phe Ile Glu Thr Gly Glu Glu Cys Asp Cys Gly Thr Pro Ala 
    450                 455                 460


Glu Cys Val Leu Glu Gly Ala Glu Cys Cys Lys Lys Cys Thr Leu Thr 
465                 470                 475                 480


Gln Asp Ser Gln Cys Ser Asp Gly Leu Cys Cys Lys Lys Cys Lys Phe 
                485                 490                 495


Gln Pro Met Gly Thr Val Cys Arg Glu Ala Val Asn Asp Cys Asp Ile 
            500                 505                 510


Arg Glu Thr Cys Ser Gly Asn Ser Ser Gln Cys Ala Pro Asn Ile His 
        515                 520                 525


Lys Met Asp Gly Tyr Ser Cys Asp Gly Val Gln Gly Ile Cys Phe Gly 
    530                 535                 540


Gly Arg Cys Lys Thr Arg Asp Arg Gln Cys Lys Tyr Ile Trp Gly Gln 
545                 550                 555                 560


Lys Val Thr Ala Ser Asp Lys Tyr Cys Tyr Glu Lys Leu Asn Ile Glu 
                565                 570                 575


Gly Thr Glu Lys Gly Asn Cys Gly Lys Asp Lys Asp Thr Trp Ile Gln 
            580                 585                 590


Cys Asn Lys Arg Asp Val Leu Cys Gly Tyr Leu Leu Cys Thr Asn Ile 
        595                 600                 605


Gly Asn Ile Pro Arg Leu Gly Glu Leu Asp Gly Glu Ile Thr Ser Thr 
    610                 615                 620


Leu Val Val Gln Gln Gly Arg Thr Leu Asn Cys Ser Gly Gly His Val 
625                 630                 635                 640


Lys Leu Glu Glu Asp Val Asp Leu Gly Tyr Val Glu Asp Gly Thr Pro 
                645                 650                 655


Cys Gly Pro Gln Met Met Cys Leu Glu His Arg Cys Leu Pro Val Ala 
            660                 665                 670


Ser Phe Asn Phe Ser Thr Cys Leu Ser Ser Lys Glu Gly Thr Ile Cys 
        675                 680                 685


Ser Gly Asn Gly Val Cys Ser Asn Glu Leu Lys Cys Val Cys Asn Arg 
    690                 695                 700


His Trp Ile Gly Ser Asp Cys Asn Thr Tyr Phe Pro His Asn Asp Asp 
705                 710                 715                 720


Ala Lys Thr Gly Ile Thr Leu Ser Gly Asn Gly Val Ala Gly Thr Asn 
                725                 730                 735


Ile Ile Ile Gly Ile Ile Ala Gly Thr Ile Leu Val Leu Ala Leu Ile 
            740                 745                 750


Leu Gly Ile Thr Ala Trp Gly Tyr Lys Asn Tyr Arg Glu Gln Arg Ser 
        755                 760                 765


Asn Gly Leu Ser His Ser Trp Ser Glu Arg Ile Pro Asp Thr Lys His 
    770                 775                 780


Ile Ser Asp Ile Cys Glu Asn Gly Arg Pro Arg Ser Asn Ser Trp Gln 
785                 790                 795                 800


Gly Asn Leu Gly Gly Asn Lys Lys Lys Ile Arg Gly Lys Arg Phe Arg 
                805                 810                 815


Pro Arg Ser Asn Ser Thr Glu 
            820


<210>  497
<211>  3393
<212>  DNA
<213>  Homo sapiens

<400>  497
gcggagcgag ggaaacggac tcggcggcgc cggcatgagg agctgagcgt ctcgggcgag     60

gcgggctgac ggcagcacca tgcaggcggc agtggctgtg tccgtgccct tcttgctgct    120

ctgtgtcctg gggacctgcc ctccggcgcg ctgcggccag gcaggagacg cctcattgat    180

ggagctagag aagaggaagg aaaaccgctt cgtggagcgc cagagcatcg tgccactgcg    240

cctcatctac cgctcgggcg gcgaagacga aagtcggcac gacgcgctcg acacgcgggt    300

gcggggcgac ctcggtggcc cgcagttgac tcatgttgac caagcaagct tccaggttga    360

tgcctttgga acgtcattca ttctcgatgt cgtgctaaat catgatttgc tgtcctctga    420

atacatagag agacacattg aacatggagg caagactgtg gaagttaaag gaggagagca    480

ctgttactac cagggccata tccgaggaaa ccctgactca tttgttgcat tgtcaacatg    540

ccacggactt catgggatgt tctatgacgg gaaccacaca tatctcattg agccagaaga    600

aaatgacact actcaagagg atttccattt tcattcagtt tacaaatcca gactgtttga    660

attttccttg gatgatcttc catctgaatt tcagcaagta aacattactc catcaaaatt    720

tattttgaag ccaagaccaa aaaggagtaa acggcagctt cgtcgatatc ctcgtaatgt    780

agaagaagaa accaaataca ttgaactgat gattgtgaat gatcacctta tgtttaaaaa    840

acatcggctt tccgttgtac ataccaatac ctatgcgaaa tctgtggtga acatggcaga    900

tttaatatat aaagaccaac ttaagaccag gatagtattg gttgctatgg aaacctgggc    960

gactgacaac aagtttgcca tatctgaaaa tccattgatc accctacgtg agtttatgaa   1020

atacaggagg gattttatca aagagaaaag tgatgcagtt cacctttttt cgggaagtca   1080

atttgagagt agccggagcg gggcagctta tattggtggg atttgctcgt tgctgaaagg   1140

aggaggcgtg aatgaatttg ggaaaactga tttaatggct gttacacttg cccagtcatt   1200

agcccataat attggtatta tctcagacaa aagaaagtta gcaagtggtg aatgtaaatg   1260

cgaggacacg tggtccgggt gcataatggg agacactggc tattatcttc ctaaaaagtt   1320

cacccagtgt aatattgaag agtatcatga cttcctgaat agtggaggtg gtgcctgcct   1380

tttcaacaaa ccttctaagc ttcttgatcc tcctgagtgt ggcaatggct tcattgaaac   1440

tggagaggag tgtgattgtg gaaccccggc cgaatgtgtc cttgaaggag cagagtgttg   1500

taagaaatgc accttgactc aagactctca atgcagtgac ggtctttgct gtaaaaagtg   1560

caagtttcag cctatgggca ctgtgtgccg agaagcagta aatgattgtg atattcgtga   1620

aacgtgctca ggaaattcaa gccagtgtgc ccctaatatt cataaaatgg atggatattc   1680

atgtgatggt gttcagggaa tttgctttgg aggaagatgc aaaaccagag atagacaatg   1740

caaatacatt tgggggcaaa aggtgacagc atcagacaaa tattgctatg agaaactgaa   1800

tattgaaggg acggagaagg gtaactgtgg gaaagacaaa gacacatgga tacagtgcaa   1860

caaacgggat gtgctttgtg gttacctttt gtgtaccaat attggcaata tcccaaggct   1920

tggagaactc gatggtgaaa tcacatctac tttagttgtg cagcaaggaa gaacattaaa   1980

ctgcagtggt gggcatgtta agcttgaaga agatgtagat cttggctatg tggaagatgg   2040

gacaccttgt ggtccccaaa tgatgtgctt agaacacagg tgtcttcctg tggcttcttt   2100

caactttagt acttgcttga gcagtaaaga aggcactatt tgctcaggaa atggagtttg   2160

cagtaatgag ctgaagtgtg tgtgtaacag acactggata ggttctgatt gcaacactta   2220

cttccctcac aatgatgatg caaagactgg tatcactctg tctggcaatg gtgttgctgg   2280

caccaatatc ataataggca taattgctgg caccatttta gtgctggccc tcatattagg   2340

aataactgcg tggggttata aaaactatcg agaacagagg tcaaatgggc tctctcattc   2400

ttggagtgaa aggattccag acacaaaaca tatttcagac atctgtgaaa atgggcgacc   2460

tcgaagtaac tcttggcaag gtaacctggg aggcaacaaa aagaaaatca gaggcaaaag   2520

atttagacct cggtctaatt caactgagta tttaaaccca tggttcaaaa gagactataa   2580

tgtagctaag tgggtagaag atgtgaataa aaacactgaa ggaccatact ttaggacttt   2640

atctcctgcc aagtctcctt cttcatcaac tgggtctatt gcctccagca gaaaataccc   2700

ttacccaatg cctccacttc ctgatgagga caagaaagtg aaccgacaaa gtgccaggct   2760

atgggagaca tccatttaag atcaactgtt tacatgtgat acatcgaaaa ctgtttactt   2820

caacttttac ttcagacaat acgaagaccc tctgagatgc tacagaggag aggaagcgga   2880

gtttcacatc tggttaccat tttctttttg tcattggctt aggatttaac taaccatgaa   2940

aagaactact gaaatattac actataacat ggaacaataa aggtactggt atgttaatgg   3000

ataatccgca tgacagataa tatgtagaaa tattcataaa gttaactcac atgacccaaa   3060

tgtagcaagt ttcctaaggt acaatagtgg attcagaact tgacgttctg aggcacatcc   3120

tcactgtaaa cagtaatgct atatgcatga agcttctgtt tattgttttc catatttaag   3180

gaaacaacat cccataatag aaatgagcat gcagggctaa ggcatatagg atttttctgc   3240

aggactttaa agctttgaaa ggccaatatc ccataggcta actttaaaca tgtattttta   3300

tttttgtttt gttttttact tttcatattt atattagcat acaaggacaa ttgtatatat   3360

gtaacatttt taaaatttta aaaaaaaaaa aaa                                3393


<210>  498
<211>  899
<212>  PRT
<213>  Homo sapiens

<400>  498

Met Gln Ala Ala Val Ala Val Ser Val Pro Phe Leu Leu Leu Cys Val 
1               5                   10                  15


Leu Gly Thr Cys Pro Pro Ala Arg Cys Gly Gln Ala Gly Asp Ala Ser 
            20                  25                  30


Leu Met Glu Leu Glu Lys Arg Lys Glu Asn Arg Phe Val Glu Arg Gln 
        35                  40                  45


Ser Ile Val Pro Leu Arg Leu Ile Tyr Arg Ser Gly Gly Glu Asp Glu 
    50                  55                  60


Ser Arg His Asp Ala Leu Asp Thr Arg Val Arg Gly Asp Leu Gly Gly 
65                  70                  75                  80


Pro Gln Leu Thr His Val Asp Gln Ala Ser Phe Gln Val Asp Ala Phe 
                85                  90                  95


Gly Thr Ser Phe Ile Leu Asp Val Val Leu Asn His Asp Leu Leu Ser 
            100                 105                 110


Ser Glu Tyr Ile Glu Arg His Ile Glu His Gly Gly Lys Thr Val Glu 
        115                 120                 125


Val Lys Gly Gly Glu His Cys Tyr Tyr Gln Gly His Ile Arg Gly Asn 
    130                 135                 140


Pro Asp Ser Phe Val Ala Leu Ser Thr Cys His Gly Leu His Gly Met 
145                 150                 155                 160


Phe Tyr Asp Gly Asn His Thr Tyr Leu Ile Glu Pro Glu Glu Asn Asp 
                165                 170                 175


Thr Thr Gln Glu Asp Phe His Phe His Ser Val Tyr Lys Ser Arg Leu 
            180                 185                 190


Phe Glu Phe Ser Leu Asp Asp Leu Pro Ser Glu Phe Gln Gln Val Asn 
        195                 200                 205


Ile Thr Pro Ser Lys Phe Ile Leu Lys Pro Arg Pro Lys Arg Ser Lys 
    210                 215                 220


Arg Gln Leu Arg Arg Tyr Pro Arg Asn Val Glu Glu Glu Thr Lys Tyr 
225                 230                 235                 240


Ile Glu Leu Met Ile Val Asn Asp His Leu Met Phe Lys Lys His Arg 
                245                 250                 255


Leu Ser Val Val His Thr Asn Thr Tyr Ala Lys Ser Val Val Asn Met 
            260                 265                 270


Ala Asp Leu Ile Tyr Lys Asp Gln Leu Lys Thr Arg Ile Val Leu Val 
        275                 280                 285


Ala Met Glu Thr Trp Ala Thr Asp Asn Lys Phe Ala Ile Ser Glu Asn 
    290                 295                 300


Pro Leu Ile Thr Leu Arg Glu Phe Met Lys Tyr Arg Arg Asp Phe Ile 
305                 310                 315                 320


Lys Glu Lys Ser Asp Ala Val His Leu Phe Ser Gly Ser Gln Phe Glu 
                325                 330                 335


Ser Ser Arg Ser Gly Ala Ala Tyr Ile Gly Gly Ile Cys Ser Leu Leu 
            340                 345                 350


Lys Gly Gly Gly Val Asn Glu Phe Gly Lys Thr Asp Leu Met Ala Val 
        355                 360                 365


Thr Leu Ala Gln Ser Leu Ala His Asn Ile Gly Ile Ile Ser Asp Lys 
    370                 375                 380


Arg Lys Leu Ala Ser Gly Glu Cys Lys Cys Glu Asp Thr Trp Ser Gly 
385                 390                 395                 400


Cys Ile Met Gly Asp Thr Gly Tyr Tyr Leu Pro Lys Lys Phe Thr Gln 
                405                 410                 415


Cys Asn Ile Glu Glu Tyr His Asp Phe Leu Asn Ser Gly Gly Gly Ala 
            420                 425                 430


Cys Leu Phe Asn Lys Pro Ser Lys Leu Leu Asp Pro Pro Glu Cys Gly 
        435                 440                 445


Asn Gly Phe Ile Glu Thr Gly Glu Glu Cys Asp Cys Gly Thr Pro Ala 
    450                 455                 460


Glu Cys Val Leu Glu Gly Ala Glu Cys Cys Lys Lys Cys Thr Leu Thr 
465                 470                 475                 480


Gln Asp Ser Gln Cys Ser Asp Gly Leu Cys Cys Lys Lys Cys Lys Phe 
                485                 490                 495


Gln Pro Met Gly Thr Val Cys Arg Glu Ala Val Asn Asp Cys Asp Ile 
            500                 505                 510


Arg Glu Thr Cys Ser Gly Asn Ser Ser Gln Cys Ala Pro Asn Ile His 
        515                 520                 525


Lys Met Asp Gly Tyr Ser Cys Asp Gly Val Gln Gly Ile Cys Phe Gly 
    530                 535                 540


Gly Arg Cys Lys Thr Arg Asp Arg Gln Cys Lys Tyr Ile Trp Gly Gln 
545                 550                 555                 560


Lys Val Thr Ala Ser Asp Lys Tyr Cys Tyr Glu Lys Leu Asn Ile Glu 
                565                 570                 575


Gly Thr Glu Lys Gly Asn Cys Gly Lys Asp Lys Asp Thr Trp Ile Gln 
            580                 585                 590


Cys Asn Lys Arg Asp Val Leu Cys Gly Tyr Leu Leu Cys Thr Asn Ile 
        595                 600                 605


Gly Asn Ile Pro Arg Leu Gly Glu Leu Asp Gly Glu Ile Thr Ser Thr 
    610                 615                 620


Leu Val Val Gln Gln Gly Arg Thr Leu Asn Cys Ser Gly Gly His Val 
625                 630                 635                 640


Lys Leu Glu Glu Asp Val Asp Leu Gly Tyr Val Glu Asp Gly Thr Pro 
                645                 650                 655


Cys Gly Pro Gln Met Met Cys Leu Glu His Arg Cys Leu Pro Val Ala 
            660                 665                 670


Ser Phe Asn Phe Ser Thr Cys Leu Ser Ser Lys Glu Gly Thr Ile Cys 
        675                 680                 685


Ser Gly Asn Gly Val Cys Ser Asn Glu Leu Lys Cys Val Cys Asn Arg 
    690                 695                 700


His Trp Ile Gly Ser Asp Cys Asn Thr Tyr Phe Pro His Asn Asp Asp 
705                 710                 715                 720


Ala Lys Thr Gly Ile Thr Leu Ser Gly Asn Gly Val Ala Gly Thr Asn 
                725                 730                 735


Ile Ile Ile Gly Ile Ile Ala Gly Thr Ile Leu Val Leu Ala Leu Ile 
            740                 745                 750


Leu Gly Ile Thr Ala Trp Gly Tyr Lys Asn Tyr Arg Glu Gln Arg Ser 
        755                 760                 765


Asn Gly Leu Ser His Ser Trp Ser Glu Arg Ile Pro Asp Thr Lys His 
    770                 775                 780


Ile Ser Asp Ile Cys Glu Asn Gly Arg Pro Arg Ser Asn Ser Trp Gln 
785                 790                 795                 800


Gly Asn Leu Gly Gly Asn Lys Lys Lys Ile Arg Gly Lys Arg Phe Arg 
                805                 810                 815


Pro Arg Ser Asn Ser Thr Glu Tyr Leu Asn Pro Trp Phe Lys Arg Asp 
            820                 825                 830


Tyr Asn Val Ala Lys Trp Val Glu Asp Val Asn Lys Asn Thr Glu Gly 
        835                 840                 845


Pro Tyr Phe Arg Thr Leu Ser Pro Ala Lys Ser Pro Ser Ser Ser Thr 
    850                 855                 860


Gly Ser Ile Ala Ser Ser Arg Lys Tyr Pro Tyr Pro Met Pro Pro Leu 
865                 870                 875                 880


Pro Asp Glu Asp Lys Lys Val Asn Arg Gln Ser Ala Arg Leu Trp Glu 
                885                 890                 895


Thr Ser Ile 



<210>  499
<211>  3455
<212>  DNA
<213>  Homo sapiens

<400>  499
gcggagcgag ggaaacggac tcggcggcgc cggcatgagg agctgagcgt ctcgggcgag     60

gcgggctgac ggcagcacca tgcaggcggc agtggctgtg tccgtgccct tcttgctgct    120

ctgtgtcctg gggacctgcc ctccggcgcg ctgcggccag gcaggagacg cctcattgat    180

ggagctagag aagaggaagg aaaaccgctt cgtggagcgc cagagcatcg tgccactgcg    240

cctcatctac cgctcgggcg gcgaagacga aagtcggcac gacgcgctcg acacgcgggt    300

gcggggcgac ctcggtggcc cgcagttgac tcatgttgac caagcaagct tccaggttga    360

tgcctttgga acgtcattca ttctcgatgt cgtgctaaat catgatttgc tgtcctctga    420

atacatagag agacacattg aacatggagg caagactgtg gaagttaaag gaggagagca    480

ctgttactac cagggccata tccgaggaaa ccctgactca tttgttgcat tgtcaacatg    540

ccacggactt catgggatgt tctatgacgg gaaccacaca tatctcattg agccagaaga    600

aaatgacact actcaagagg atttccattt tcattcagtt tacaaatcca gactgtttga    660

attttccttg gatgatcttc catctgaatt tcagcaagta aacattactc catcaaaatt    720

tattttgaag ccaagaccaa aaaggagtaa acggcagctt cgtcgatatc ctcgtaatgt    780

agaagaagaa accaaataca ttgaactgat gattgtgaat gatcacctta tgtttaaaaa    840

acatcggctt tccgttgtac ataccaatac ctatgcgaaa tctgtggtga acatggcaga    900

tttaatatat aaagaccaac ttaagaccag gatagtattg gttgctatgg aaacctgggc    960

gactgacaac aagtttgcca tatctgaaaa tccattgatc accctacgtg agtttatgaa   1020

atacaggagg gattttatca aagagaaaag tgatgcagtt cacctttttt cgggaagtca   1080

atttgagagt agccggagcg gggcagctta tattggtggg atttgctcgt tgctgaaagg   1140

aggaggcgtg aatgaatttg ggaaaactga tttaatggct gttacacttg cccagtcatt   1200

agcccataat attggtatta tctcagacaa aagaaagtta gcaagtggtg aatgtaaatg   1260

cgaggacacg tggtccgggt gcataatggg agacactggc tattatcttc ctaaaaagtt   1320

cacccagtgt aatattgaag agtatcatga cttcctgaat agtggaggtg gtgcctgcct   1380

tttcaacaaa ccttctaagc ttcttgatcc tcctgagtgt ggcaatggct tcattgaaac   1440

tggagaggag tgtgattgtg gaaccccggc cgaatgtgtc cttgaaggag cagagtgttg   1500

taagaaatgc accttgactc aagactctca atgcagtgac ggtctttgct gtaaaaagtg   1560

caagtttcag cctatgggca ctgtgtgccg agaagcagta aatgattgtg atattcgtga   1620

aacgtgctca ggaaattcaa gccagtgtgc ccctaatatt cataaaatgg atggatattc   1680

atgtgatggt gttcagggaa tttgctttgg aggaagatgc aaaaccagag atagacaatg   1740

caaatacatt tgggggcaaa aggtgacagc atcagacaaa tattgctatg agaaactgaa   1800

tattgaaggg acggagaagg gtaactgtgg gaaagacaaa gacacatgga tacagtgcaa   1860

caaacgggat gtgctttgtg gttacctttt gtgtaccaat attggcaata tcccaaggct   1920

tggagaactc gatggtgaaa tcacatctac tttagttgtg cagcaaggaa gaacattaaa   1980

ctgcagtggt gggcatgtta agcttgaaga agatgtagat cttggctatg tggaagatgg   2040

gacaccttgt ggtccccaaa tgatgtgctt agaacacagg tgtcttcctg tggcttcttt   2100

caactttagt acttgcttga gcagtaaaga aggcactatt tgctcaggaa atggagtttg   2160

cagtaatgag ctgaagtgtg tgtgtaacag acactggata ggttctgatt gcaacactta   2220

cttccctcac aatgatgatg caaagactgg tatcactctg tctggcaatg gtgttgctgg   2280

caccaatatc ataataggca taattgctgg caccatttta gtgctggccc tcatattagg   2340

aataactgcg tggggttata aaaactatcg agaacagaga cagttacccc agggagatta   2400

tgtaaaaaag cctggagatg gtgactcttt ttatagcgac attcctcccg gagtcagcac   2460

aaactcagca tctagttcta agaagaggtc aaatgggctc tctcattctt ggagtgaaag   2520

gattccagac acaaaacata tttcagacat ctgtgaaaat gggcgacctc gaagtaactc   2580

ttggcaaggt aacctgggag gcaacaaaaa gaaaatcaga ggcaaaagat ttagacctcg   2640

gtctaattca actgagactt tatctcctgc caagtctcct tcttcatcaa ctgggtctat   2700

tgcctccagc agaaaatacc cttacccaat gcctccactt cctgatgagg acaagaaagt   2760

gaaccgacaa agtgccaggc tatgggagac atccatttaa gatcaactgt ttacatgtga   2820

tacatcgaaa actgtttact tcaactttta tagaaaccca ggctcatgga atcactgcaa   2880

atctatctgc tcttcagaca atacgaagac cctctgagat gctacagagg agaggaagcg   2940

gagtttcaca tctggttacc attttctttt tgtcattggc ttaggattta actaaccatg   3000

aaaagaacta ctgaaatatt acactataac atggaacaat aaaggtactg gtatgttaat   3060

ggataatccg catgacagat aatatgtaga aatattcata aagttaactc acatgaccca   3120

aatgtagcaa gtttcctaag gtacaatagt ggattcagaa cttgacgttc tgaggcacat   3180

cctcactgta aacagtaatg ctatatgcat gaagcttctg tttattgttt tccatattta   3240

aggaaacaac atcccataat agaaatgagc atgcagggct aaggcatata ggatttttct   3300

gcaggacttt aaagctttga aaggccaata tcccataggc taactttaaa catgtatttt   3360

tatttttgtt ttgtttttta cttttcatat ttatattagc atacaaggac aattgtatat   3420

atgtaacatt tttaaaattt taaaaaaaaa aaaaa                              3455


<210>  500
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  500

Met Gln Ala Ala Val Ala Val Ser Val Pro Phe Leu Leu Leu Cys Val 
1               5                   10                  15


Leu Gly Thr Cys Pro Pro Ala Arg Cys Gly Gln Ala Gly Asp Ala Ser 
            20                  25                  30


Leu Met Glu Leu Glu Lys Arg Lys Glu Asn Arg Phe Val Glu Arg Gln 
        35                  40                  45


Ser Ile Val Pro Leu Arg Leu Ile Tyr Arg Ser Gly Gly Glu Asp Glu 
    50                  55                  60


Ser Arg His Asp Ala Leu Asp Thr Arg Val Arg Gly Asp Leu Gly Gly 
65                  70                  75                  80


Pro Gln Leu Thr His Val Asp Gln Ala Ser Phe Gln Val Asp Ala Phe 
                85                  90                  95


Gly Thr Ser Phe Ile Leu Asp Val Val Leu Asn His Asp Leu Leu Ser 
            100                 105                 110


Ser Glu Tyr Ile Glu Arg His Ile Glu His Gly Gly Lys Thr Val Glu 
        115                 120                 125


Val Lys Gly Gly Glu His Cys Tyr Tyr Gln Gly His Ile Arg Gly Asn 
    130                 135                 140


Pro Asp Ser Phe Val Ala Leu Ser Thr Cys His Gly Leu His Gly Met 
145                 150                 155                 160


Phe Tyr Asp Gly Asn His Thr Tyr Leu Ile Glu Pro Glu Glu Asn Asp 
                165                 170                 175


Thr Thr Gln Glu Asp Phe His Phe His Ser Val Tyr Lys Ser Arg Leu 
            180                 185                 190


Phe Glu Phe Ser Leu Asp Asp Leu Pro Ser Glu Phe Gln Gln Val Asn 
        195                 200                 205


Ile Thr Pro Ser Lys Phe Ile Leu Lys Pro Arg Pro Lys Arg Ser Lys 
    210                 215                 220


Arg Gln Leu Arg Arg Tyr Pro Arg Asn Val Glu Glu Glu Thr Lys Tyr 
225                 230                 235                 240


Ile Glu Leu Met Ile Val Asn Asp His Leu Met Phe Lys Lys His Arg 
                245                 250                 255


Leu Ser Val Val His Thr Asn Thr Tyr Ala Lys Ser Val Val Asn Met 
            260                 265                 270


Ala Asp Leu Ile Tyr Lys Asp Gln Leu Lys Thr Arg Ile Val Leu Val 
        275                 280                 285


Ala Met Glu Thr Trp Ala Thr Asp Asn Lys Phe Ala Ile Ser Glu Asn 
    290                 295                 300


Pro Leu Ile Thr Leu Arg Glu Phe Met Lys Tyr Arg Arg Asp Phe Ile 
305                 310                 315                 320


Lys Glu Lys Ser Asp Ala Val His Leu Phe Ser Gly Ser Gln Phe Glu 
                325                 330                 335


Ser Ser Arg Ser Gly Ala Ala Tyr Ile Gly Gly Ile Cys Ser Leu Leu 
            340                 345                 350


Lys Gly Gly Gly Val Asn Glu Phe Gly Lys Thr Asp Leu Met Ala Val 
        355                 360                 365


Thr Leu Ala Gln Ser Leu Ala His Asn Ile Gly Ile Ile Ser Asp Lys 
    370                 375                 380


Arg Lys Leu Ala Ser Gly Glu Cys Lys Cys Glu Asp Thr Trp Ser Gly 
385                 390                 395                 400


Cys Ile Met Gly Asp Thr Gly Tyr Tyr Leu Pro Lys Lys Phe Thr Gln 
                405                 410                 415


Cys Asn Ile Glu Glu Tyr His Asp Phe Leu Asn Ser Gly Gly Gly Ala 
            420                 425                 430


Cys Leu Phe Asn Lys Pro Ser Lys Leu Leu Asp Pro Pro Glu Cys Gly 
        435                 440                 445


Asn Gly Phe Ile Glu Thr Gly Glu Glu Cys Asp Cys Gly Thr Pro Ala 
    450                 455                 460


Glu Cys Val Leu Glu Gly Ala Glu Cys Cys Lys Lys Cys Thr Leu Thr 
465                 470                 475                 480


Gln Asp Ser Gln Cys Ser Asp Gly Leu Cys Cys Lys Lys Cys Lys Phe 
                485                 490                 495


Gln Pro Met Gly Thr Val Cys Arg Glu Ala Val Asn Asp Cys Asp Ile 
            500                 505                 510


Arg Glu Thr Cys Ser Gly Asn Ser Ser Gln Cys Ala Pro Asn Ile His 
        515                 520                 525


Lys Met Asp Gly Tyr Ser Cys Asp Gly Val Gln Gly Ile Cys Phe Gly 
    530                 535                 540


Gly Arg Cys Lys Thr Arg Asp Arg Gln Cys Lys Tyr Ile Trp Gly Gln 
545                 550                 555                 560


Lys Val Thr Ala Ser Asp Lys Tyr Cys Tyr Glu Lys Leu Asn Ile Glu 
                565                 570                 575


Gly Thr Glu Lys Gly Asn Cys Gly Lys Asp Lys Asp Thr Trp Ile Gln 
            580                 585                 590


Cys Asn Lys Arg Asp Val Leu Cys Gly Tyr Leu Leu Cys Thr Asn Ile 
        595                 600                 605


Gly Asn Ile Pro Arg Leu Gly Glu Leu Asp Gly Glu Ile Thr Ser Thr 
    610                 615                 620


Leu Val Val Gln Gln Gly Arg Thr Leu Asn Cys Ser Gly Gly His Val 
625                 630                 635                 640


Lys Leu Glu Glu Asp Val Asp Leu Gly Tyr Val Glu Asp Gly Thr Pro 
                645                 650                 655


Cys Gly Pro Gln Met Met Cys Leu Glu His Arg Cys Leu Pro Val Ala 
            660                 665                 670


Ser Phe Asn Phe Ser Thr Cys Leu Ser Ser Lys Glu Gly Thr Ile Cys 
        675                 680                 685


Ser Gly Asn Gly Val Cys Ser Asn Glu Leu Lys Cys Val Cys Asn Arg 
    690                 695                 700


His Trp Ile Gly Ser Asp Cys Asn Thr Tyr Phe Pro His Asn Asp Asp 
705                 710                 715                 720


Ala Lys Thr Gly Ile Thr Leu Ser Gly Asn Gly Val Ala Gly Thr Asn 
                725                 730                 735


Ile Ile Ile Gly Ile Ile Ala Gly Thr Ile Leu Val Leu Ala Leu Ile 
            740                 745                 750


Leu Gly Ile Thr Ala Trp Gly Tyr Lys Asn Tyr Arg Glu Gln Arg Gln 
        755                 760                 765


Leu Pro Gln Gly Asp Tyr Val Lys Lys Pro Gly Asp Gly Asp Ser Phe 
    770                 775                 780


Tyr Ser Asp Ile Pro Pro Gly Val Ser Thr Asn Ser Ala Ser Ser Ser 
785                 790                 795                 800


Lys Lys Arg Ser Asn Gly Leu Ser His Ser Trp Ser Glu Arg Ile Pro 
                805                 810                 815


Asp Thr Lys His Ile Ser Asp Ile Cys Glu Asn Gly Arg Pro Arg Ser 
            820                 825                 830


Asn Ser Trp Gln Gly Asn Leu Gly Gly Asn Lys Lys Lys Ile Arg Gly 
        835                 840                 845


Lys Arg Phe Arg Pro Arg Ser Asn Ser Thr Glu Thr Leu Ser Pro Ala 
    850                 855                 860


Lys Ser Pro Ser Ser Ser Thr Gly Ser Ile Ala Ser Ser Arg Lys Tyr 
865                 870                 875                 880


Pro Tyr Pro Met Pro Pro Leu Pro Asp Glu Asp Lys Lys Val Asn Arg 
                885                 890                 895


Gln Ser Ala Arg Leu Trp Glu Thr Ser Ile 
            900                 905


<210>  501
<211>  422
<212>  DNA
<213>  Homo sapiens

<400>  501
catatgttga tcccaaacat gcaatgacat ccatataaac cttgcaaaat gatggctgtg     60

atgacaccca gtgatggtct ttctcaactc tctgtacctc atctcactca tcagagactt    120

tggagcctca gttgccttgc aatgctgttt caggctgtac tcattctttc tgcaccacaa    180

atgtcatgcc ttctcaagtg tttttatgcc ctggacccat tgcatccagt gatgtcagag    240

gaattctcag ctcaatatcg tcacatgatg gatcagagat acagaactag aattcatgag    300

ggatacatat ctcaagtgaa aggtgcatat ctacggattg tccacaagaa accaatcagt    360

tatgcaaaat cttttccaaa ggaaatggga aattaaggaa aaaagtgaat aaaactttac    420

aa                                                                   422


<210>  502
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  502

Met Met Ala Val Met Thr Pro Ser Asp Gly Leu Ser Gln Leu Ser Val 
1               5                   10                  15


Pro His Leu Thr His Gln Arg Leu Trp Ser Leu Ser Cys Leu Ala Met 
            20                  25                  30


Leu Phe Gln Ala Val Leu Ile Leu Ser Ala Pro Gln Met Ser Cys Leu 
        35                  40                  45


Leu Lys Cys Phe Tyr Ala Leu Asp Pro Leu His Pro Val Met Ser Glu 
    50                  55                  60


Glu Phe Ser Ala Gln Tyr Arg His Met Met Asp Gln Arg Tyr Arg Thr 
65                  70                  75                  80


Arg Ile His Glu Gly Tyr Ile Ser Gln Val Lys Gly Ala Tyr Leu Arg 
                85                  90                  95


Ile Val His Lys Lys Pro Ile Ser Tyr Ala Lys Ser Phe Pro Lys Glu 
            100                 105                 110


Met Gly Asn 
        115


<210>  503
<211>  3811
<212>  DNA
<213>  Homo sapiens

<400>  503
ctattgaagc cacctgctca ggacaatgaa attcttcagt tacattctgg tttatcgccg     60

atttctcttc gtggttttca ctgtgttggt tttactacct ctgcccatcg tcctccacac    120

caaggaagca gaatgtgcct acacactctt tgtggtcgcc acattttggc tcacagaagc    180

attgcctctg tcggtaacag ctttgctacc tagtttaatg ttacccatgt ttgggatcat    240

gccttctaag aaggtggcat ctgcttattt caaggatttt cacttactgc taattggagt    300

tatctgttta gcaacatcca tagaaaaatg gaatttgcac aagagaattg ctctgaaaat    360

ggtgatgatg gttggtgtaa atcctgcatg gctgacgctg gggttcatga gcagcactgc    420

ctttttgtct atgtggctca gcaacacctc gacggctgcc atggtgatgc ccattgcgga    480

ggctgtagtg cagcagatca tcaatgcaga agcagaggtc gaggccactc agatgactta    540

cttcaacgga tcaaccaacc acggactaga aattgatgaa agtgttaatg gacatgaaat    600

aaatgagagg aaagagaaaa caaaaccagt tccaggatac aataatgata cagggaaaat    660

ttcaagcaag gtggagttgg aaaagaactc aggcatgaga accaaatatc gaacaaagaa    720

gggccacgtg acacgtaaac ttacgtgttt gtgcattgcc tactcttcta ccattggtgg    780

actgacaaca atcactggta cctccaccaa cttgatcttt gcagagtatt tcaatacacg    840

ctatcctgac tgtcgttgcc tcaactttgg atcatggttt acgttttcct tcccagctgc    900

ccttatcatt ctactcttat cctggatctg gcttcagtgg cttttcctag gattcaattt    960

taaggagatg ttcaaatgtg gcaaaaccaa aacagtccaa caaaaagctt gtgctgaggt   1020

gattaagcaa gaataccaaa agcttgggcc aataaggtat caagaaattg tgaccttggt   1080

cctcttcatt ataatggctc tgctatggtt tagtcgagac cccggatttg ttcctggttg   1140

gtctgcactt ttttcagagt accctggttt tgctacagat tcaactgttg ctttacttat   1200

agggctgcta ttctttctta tcccagctaa gacactgact aaaactacac ctacaggaga   1260

aattgttgct tttgattact ctccactgat tacttggaaa gaattccagt cattcatgcc   1320

ctgggatata gccattcttg ttggtggagg gtttgccctg gcagatggtt gtgaggagtc   1380

tggattatct aagtggatag gaaataaatt atctcctctg ggttcattac cagcatggct   1440

aataattctg atatcttctt tgatggtgac atctttaact gaggtagcca gcaatccagc   1500

taccattaca ctctttctcc caatattatc tccattggcc gaagccattc atgtgaaccc   1560

tctttatatt ctgatacctt ctactctgtg tacttcattt gcattcctcc taccagtagc   1620

aaatccaccc aatgctattg tcttttcata tggtcatctg aaagtcattg acatggttaa   1680

agctggactt ggtgtcaaca ttgttggtgt tgctgtggtt atgcttggca tatgtacttg   1740

gattgtaccc atgtttgacc tctacactta cccttcgtgg gctcctgcta tgagtaatga   1800

gaccatgcca taataagcac aaaatttctg actatcttgc ggtaatttct ggaagacatt   1860

aatgattgac tgtaaaatgt ggctctaaat aactaatgac acacatttaa atcagttatg   1920

gtgtagctgc tgcaattccc gtgaataccc gaaacctgct gttataactc agagtccata   1980

tttgttattg cagtgcaact aaagagcatc tatgtgcctt catcaagaag cccatgtttt   2040

gagattttgc tcatgaacca tctgcaactt gcttcatcat aagaataatt tataacttga   2100

ccttcaaaga gattagagca tttgtttcat cttacagttg gagttcaatg taacatttta   2160

aatgcaattt attatttcag aaatttccca tgaaactaaa aatagaaaat aagatataca   2220

agttaattcg gtacttggat aaatcatttc tgcattgttg ttccagagaa tttgctgaga   2280

aatcaaagcc atggtcatct ggtgatgaag agaaaagttt aatctaaatg atatgtgcat   2340

ttcctcattt aaaaaatcca attggattat tcttaatata tacatgtaat atgaaaattg   2400

agattgaagc actaattcca aaattatggc tgaatatact aaataacaga aaagttacag   2460

ataagaattt atttctactg aactctatag ttagtgtaat ataattcata tttttatgat   2520

attggcacac tgagaaattc attttgtaga gctatggata aggcttgcta tgatttgcac   2580

tattagtaca gtatagttag aaaggaaagc tgaacactat aaaactatta acatattttc   2640

gtatatgagt aacaactttg cttaagtgtt tatcttagtt cagaaataca taatgtcata   2700

tgttaaaaat aaagagatgt agaaatctaa atgaattatc actgtgtata cagacagaaa   2760

aatcacataa ctctggtgtg ttaacattgc aatgaaaaaa tgaaaaaaag aaggaaaaaa   2820

gaataagaat gaaaactgct gacgtattac aaaacagaaa aataaatgat ttaaaatcaa   2880

atcaaaaaga aaaaactaaa catttaaaca aaaatgggat aagaatagtc ttctagaagt   2940

gaggatgcga aaaagaatga gtttccaatt accctgatgt gacaattaca cattgtagac   3000

aggtagcaaa atatcacata cacccccaaa atatgtacaa atattatata tcaataaata   3060

aatttttaaa gagtaagtgc tattggcatt ccaaaattca gctaaaggaa aaatgatcaa   3120

aaacaaagta aggtgcacag ttagcaaaag atgcagatgt tatatcacag caattctcat   3180

gctaaaaata caacaaaaga caaagcaaaa aataaacctt tgcttttttt tttttttttt   3240

tttttttgag acggagtctc gctctgtcgc ccaggctgga gtgcagtggc gggatctcgg   3300

ctcactgcaa gctccgcctc ccaggttcac gccattctcc tgcctcagcc aaacctttgc   3360

tatttttaat cttcgttggc actttccagc tgttactgac cttgtcattt tttattcaaa   3420

taagattatt tacaaactta ttcttgaaac taaatatagt aaagagggtt tttaaaataa   3480

tatttaacat acgaattatt aattggccat gttcattatt tatctatgtt tattaatggg   3540

ccaatgcaaa aaatcatttt ttcaaagaaa aatttgtcca tgtaaagctt aaattataat   3600

attgctgctt tgtataactc ttctatgttt attctattca tttgttcctt tccctaccat   3660

attttacaca tgtatttata atctgtagta tttattacat ttctgctttt ttctagtcat   3720

tcaatttatc actgctgaat tgcatcagat catggatgca tttttattat gaaaaaataa   3780

aatgactttt caaattaaaa aaaaaaaaaa a                                  3811


<210>  504
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  504

Met Lys Phe Phe Ser Tyr Ile Leu Val Tyr Arg Arg Phe Leu Phe Val 
1               5                   10                  15


Val Phe Thr Val Leu Val Leu Leu Pro Leu Pro Ile Val Leu His Thr 
            20                  25                  30


Lys Glu Ala Glu Cys Ala Tyr Thr Leu Phe Val Val Ala Thr Phe Trp 
        35                  40                  45


Leu Thr Glu Ala Leu Pro Leu Ser Val Thr Ala Leu Leu Pro Ser Leu 
    50                  55                  60


Met Leu Pro Met Phe Gly Ile Met Pro Ser Lys Lys Val Ala Ser Ala 
65                  70                  75                  80


Tyr Phe Lys Asp Phe His Leu Leu Leu Ile Gly Val Ile Cys Leu Ala 
                85                  90                  95


Thr Ser Ile Glu Lys Trp Asn Leu His Lys Arg Ile Ala Leu Lys Met 
            100                 105                 110


Val Met Met Val Gly Val Asn Pro Ala Trp Leu Thr Leu Gly Phe Met 
        115                 120                 125


Ser Ser Thr Ala Phe Leu Ser Met Trp Leu Ser Asn Thr Ser Thr Ala 
    130                 135                 140


Ala Met Val Met Pro Ile Ala Glu Ala Val Val Gln Gln Ile Ile Asn 
145                 150                 155                 160


Ala Glu Ala Glu Val Glu Ala Thr Gln Met Thr Tyr Phe Asn Gly Ser 
                165                 170                 175


Thr Asn His Gly Leu Glu Ile Asp Glu Ser Val Asn Gly His Glu Ile 
            180                 185                 190


Asn Glu Arg Lys Glu Lys Thr Lys Pro Val Pro Gly Tyr Asn Asn Asp 
        195                 200                 205


Thr Gly Lys Ile Ser Ser Lys Val Glu Leu Glu Lys Asn Ser Gly Met 
    210                 215                 220


Arg Thr Lys Tyr Arg Thr Lys Lys Gly His Val Thr Arg Lys Leu Thr 
225                 230                 235                 240


Cys Leu Cys Ile Ala Tyr Ser Ser Thr Ile Gly Gly Leu Thr Thr Ile 
                245                 250                 255


Thr Gly Thr Ser Thr Asn Leu Ile Phe Ala Glu Tyr Phe Asn Thr Arg 
            260                 265                 270


Tyr Pro Asp Cys Arg Cys Leu Asn Phe Gly Ser Trp Phe Thr Phe Ser 
        275                 280                 285


Phe Pro Ala Ala Leu Ile Ile Leu Leu Leu Ser Trp Ile Trp Leu Gln 
    290                 295                 300


Trp Leu Phe Leu Gly Phe Asn Phe Lys Glu Met Phe Lys Cys Gly Lys 
305                 310                 315                 320


Thr Lys Thr Val Gln Gln Lys Ala Cys Ala Glu Val Ile Lys Gln Glu 
                325                 330                 335


Tyr Gln Lys Leu Gly Pro Ile Arg Tyr Gln Glu Ile Val Thr Leu Val 
            340                 345                 350


Leu Phe Ile Ile Met Ala Leu Leu Trp Phe Ser Arg Asp Pro Gly Phe 
        355                 360                 365


Val Pro Gly Trp Ser Ala Leu Phe Ser Glu Tyr Pro Gly Phe Ala Thr 
    370                 375                 380


Asp Ser Thr Val Ala Leu Leu Ile Gly Leu Leu Phe Phe Leu Ile Pro 
385                 390                 395                 400


Ala Lys Thr Leu Thr Lys Thr Thr Pro Thr Gly Glu Ile Val Ala Phe 
                405                 410                 415


Asp Tyr Ser Pro Leu Ile Thr Trp Lys Glu Phe Gln Ser Phe Met Pro 
            420                 425                 430


Trp Asp Ile Ala Ile Leu Val Gly Gly Gly Phe Ala Leu Ala Asp Gly 
        435                 440                 445


Cys Glu Glu Ser Gly Leu Ser Lys Trp Ile Gly Asn Lys Leu Ser Pro 
    450                 455                 460


Leu Gly Ser Leu Pro Ala Trp Leu Ile Ile Leu Ile Ser Ser Leu Met 
465                 470                 475                 480


Val Thr Ser Leu Thr Glu Val Ala Ser Asn Pro Ala Thr Ile Thr Leu 
                485                 490                 495


Phe Leu Pro Ile Leu Ser Pro Leu Ala Glu Ala Ile His Val Asn Pro 
            500                 505                 510


Leu Tyr Ile Leu Ile Pro Ser Thr Leu Cys Thr Ser Phe Ala Phe Leu 
        515                 520                 525


Leu Pro Val Ala Asn Pro Pro Asn Ala Ile Val Phe Ser Tyr Gly His 
    530                 535                 540


Leu Lys Val Ile Asp Met Val Lys Ala Gly Leu Gly Val Asn Ile Val 
545                 550                 555                 560


Gly Val Ala Val Val Met Leu Gly Ile Cys Thr Trp Ile Val Pro Met 
                565                 570                 575


Phe Asp Leu Tyr Thr Tyr Pro Ser Trp Ala Pro Ala Met Ser Asn Glu 
            580                 585                 590


Thr Met Pro 
        595


<210>  505
<211>  3522
<212>  DNA
<213>  Homo sapiens

<400>  505
acgcttgcgc ggcgagtaga acgtgtggcg gcggcggaga tcgcgtctct ttcgctccgt     60

gtcccgctgc tgctcctgtg agcgcccggc gagtccgtcc cgtccaccgt ccgcagctgg    120

tagccagcct gcccctcgcc tcgactccct ttcaccaaca ccgacaccca cattgacacc    180

tccagtccgg ccagccgctc cactcgttgc ctttgcatct ccacacatgg cgtcctccgc    240

gcagagcggc ggctcctccg ggggacccgc ggtccccacc gtgcagcggg gcatcatcaa    300

gatggtcctc tcagggtgcg ccatcattgt ccgaggtcag cctcgtggtg ggcctcctcc    360

tgagcggcag atcaacctca gcaacattcg tgctggaaat cttgctcgcc gggcagccgc    420

cacacaacct gatgcaaagg atacccctga tgagccctgg gcatttccag ctcgagagtt    480

ccttcgaaag aagctgattg ggaaggaagt ctgtttcacg atagaaaaca agactcccca    540

ggggcgagag tatggcatga tctaccttgg aaaagatacc aatggggaaa acattgcaga    600

atcactggtt gcagagggct tagccacccg gagagaaggc atgagagcta ataatcctga    660

gcagaaccgg ctttcagaat gtgaagaaca agcaaaggca gccaagaaag ggatgtggag    720

tgaggggaac ggttcacata ctatccggga tctcaagtat accattgaaa acccaaggca    780

ctttgtggac tcacaccacc agaagcctgt taatgctatc atcgagcatg tgcgggacgg    840

cagtgtggtc agggccctgc tcctcccaga ttactacctg gttacagtca tgctgtcagg    900

catcaagtgc ccaacttttc gacgggaagc agatggcagt gaaactccag agccttttgc    960

tgcagaagcc aaatttttca ctgagtcgcg actgcttcag agagatgttc agatcattct   1020

ggagagctgc cacaaccaga acattctggg taccatcctt catccaaatg gcaacatcac   1080

agagctcctc ctgaaggaag gtttcgcacg ctgtgtggac tggtcgattg cagtttacac   1140

ccggggcgca gaaaagctga gggcggcaga gaggtttgcc aaagagcgca ggctgagaat   1200

atggagagac tatgtggctc ccacagctaa tttggaccaa aaggacaagc agtttgttgc   1260

caaggtgatg caggttctga atgctgatgc cattgttgtg aagctgaact caggcgatta   1320

caagacgatt cacctgtcca gcatccgacc accgaggctg gagggggaga acacccagga   1380

taagaacaag aaactgcgtc ccctgtatga cattccttac atgtttgagg cccgggaatt   1440

tcttcgaaaa aagcttattg ggaagaaggt caatgtgacg gtggactaca ttagaccagc   1500

cagcccagcc acagagacag tgcctgcctt ttcagagcgt acctgtgcca ctgtcaccat   1560

tggaggaata aacattgctg aggctcttgt cagcaaaggt ctagccacag tgatcagata   1620

ccggcaggat gatgaccaga gatcatcaca ctacgatgaa ctgcttgctg cagaggccag   1680

agctattaag aatggcaaag gattgcatag caagaaggaa gtgcctatcc accgtgttgc   1740

agatatatct ggggataccc aaaaagcaaa gcagttcctg ccttttcttc agcgggcagg   1800

tcgttctgaa gctgtggtgg aatacgtctt cagtggttct cgtctcaaac tctatttgcc   1860

aaaggaaact tgccttatca ccttcttgct tgcaggcatt gaatgcccca gaggagcccg   1920

aaacctccca ggcttggtgc aggaaggaga gcccttcagc gaggaagcta cacttttcac   1980

caaggaactg gtgctgcagc gagaggtgga ggtggaggtg gagagcatgg acaaggccgg   2040

caactttatc ggctggctgc acatcgacgg tgccaacctg tccgtcctgc tggtggagca   2100

cgcgctctcc aaggtccact tcaccgccga acgcagctcc tactacaagt ccctgctgtc   2160

tgccgaggag gccgcaaagc agaagaaaga gaaggtctgg gcccactatg aggagcagcc   2220

cgtggaggag gtgatgccag tgctggagga gaaggagcga tctgctagct acaagcccgt   2280

gtttgtgact gagatcactg atgacctgca cttctacgtg caggatgtgg agaccggcac   2340

ccagttggag aagctgatgg agaacatgcg caatgacatt gccagtcacc cccctgtaga   2400

gggctcctat gccccccgca ggggagagtt ctgcattgcc aaatttgtag atggagaatg   2460

gtaccgtgcc cgagtagaga aagtcgagtc tcctgccaaa atacatgtct tctacattga   2520

ctacggcaac agagaggtcc tgccatccac ccgcctgggt accctatcac ctgccttcag   2580

cactcgggtg ctgccagctc aagccacgga gtatgccttc gccttcatcc aggtgcccca   2640

agatgatgat gcccgcacgg acgccgtgga cagcgtagtt cgggatatcc agaacactca   2700

gtgcctgctc aacgtggaac acctgagtgc cggctgcccc catgtcaccc tgcagtttgc   2760

agattccaag ggcgatgtgg ggctgggctt ggtgaaggaa gggctggtca tggtggaggt   2820

gcgcaaggag aaacagttcc agaaagtgat cacagaatac ctgaatgccc aagagtcagc   2880

caagagcgcc aggctgaacc tgtggcgcta tggagacttt cgagctgatg atgcagacga   2940

atttggctac agccgctaag gaggggatcg ggtttggccc ccagccccgc tcacgccagt   3000

ccctcttcct ctgccgggag ggtgttttca actccaaacc ccagagaggg gttgtagatt   3060

gggtccagct ttgcttcagt gtgtggaaat gtctcgtggg gtggcatcgg ggctgcgggg   3120

tggggacccc aaggctttct ggggcagacc cttgtcctct gggatgatgg gcactgctat   3180

ccacagtctc tgccagttgg ttttatttgg aggtttgtgg gcttttttta aaaaaaaaaa   3240

gtcctcaaat caggaagaaa catcaaagac tatgtcctag tggagggagt aatcctaaca   3300

cccaggctgg ccgccagctg gcacctgcct ctatcccaga ctgccctcgt cccagctctc   3360

tgtccaactg ttgattatgt gatttttctg atacgtccat tctcaaatgc cagtgtgttc   3420

acatcttcgc tctggccagc ccattctgta tttaaagctt ttgaggccca ataaaatagt   3480

acgtgctgtc tgcagccctt attgatcaaa aaaaaaaaaa aa                      3522


<210>  506
<211>  910
<212>  PRT
<213>  Homo sapiens

<400>  506

Met Ala Ser Ser Ala Gln Ser Gly Gly Ser Ser Gly Gly Pro Ala Val 
1               5                   10                  15


Pro Thr Val Gln Arg Gly Ile Ile Lys Met Val Leu Ser Gly Cys Ala 
            20                  25                  30


Ile Ile Val Arg Gly Gln Pro Arg Gly Gly Pro Pro Pro Glu Arg Gln 
        35                  40                  45


Ile Asn Leu Ser Asn Ile Arg Ala Gly Asn Leu Ala Arg Arg Ala Ala 
    50                  55                  60


Ala Thr Gln Pro Asp Ala Lys Asp Thr Pro Asp Glu Pro Trp Ala Phe 
65                  70                  75                  80


Pro Ala Arg Glu Phe Leu Arg Lys Lys Leu Ile Gly Lys Glu Val Cys 
                85                  90                  95


Phe Thr Ile Glu Asn Lys Thr Pro Gln Gly Arg Glu Tyr Gly Met Ile 
            100                 105                 110


Tyr Leu Gly Lys Asp Thr Asn Gly Glu Asn Ile Ala Glu Ser Leu Val 
        115                 120                 125


Ala Glu Gly Leu Ala Thr Arg Arg Glu Gly Met Arg Ala Asn Asn Pro 
    130                 135                 140


Glu Gln Asn Arg Leu Ser Glu Cys Glu Glu Gln Ala Lys Ala Ala Lys 
145                 150                 155                 160


Lys Gly Met Trp Ser Glu Gly Asn Gly Ser His Thr Ile Arg Asp Leu 
                165                 170                 175


Lys Tyr Thr Ile Glu Asn Pro Arg His Phe Val Asp Ser His His Gln 
            180                 185                 190


Lys Pro Val Asn Ala Ile Ile Glu His Val Arg Asp Gly Ser Val Val 
        195                 200                 205


Arg Ala Leu Leu Leu Pro Asp Tyr Tyr Leu Val Thr Val Met Leu Ser 
    210                 215                 220


Gly Ile Lys Cys Pro Thr Phe Arg Arg Glu Ala Asp Gly Ser Glu Thr 
225                 230                 235                 240


Pro Glu Pro Phe Ala Ala Glu Ala Lys Phe Phe Thr Glu Ser Arg Leu 
                245                 250                 255


Leu Gln Arg Asp Val Gln Ile Ile Leu Glu Ser Cys His Asn Gln Asn 
            260                 265                 270


Ile Leu Gly Thr Ile Leu His Pro Asn Gly Asn Ile Thr Glu Leu Leu 
        275                 280                 285


Leu Lys Glu Gly Phe Ala Arg Cys Val Asp Trp Ser Ile Ala Val Tyr 
    290                 295                 300


Thr Arg Gly Ala Glu Lys Leu Arg Ala Ala Glu Arg Phe Ala Lys Glu 
305                 310                 315                 320


Arg Arg Leu Arg Ile Trp Arg Asp Tyr Val Ala Pro Thr Ala Asn Leu 
                325                 330                 335


Asp Gln Lys Asp Lys Gln Phe Val Ala Lys Val Met Gln Val Leu Asn 
            340                 345                 350


Ala Asp Ala Ile Val Val Lys Leu Asn Ser Gly Asp Tyr Lys Thr Ile 
        355                 360                 365


His Leu Ser Ser Ile Arg Pro Pro Arg Leu Glu Gly Glu Asn Thr Gln 
    370                 375                 380


Asp Lys Asn Lys Lys Leu Arg Pro Leu Tyr Asp Ile Pro Tyr Met Phe 
385                 390                 395                 400


Glu Ala Arg Glu Phe Leu Arg Lys Lys Leu Ile Gly Lys Lys Val Asn 
                405                 410                 415


Val Thr Val Asp Tyr Ile Arg Pro Ala Ser Pro Ala Thr Glu Thr Val 
            420                 425                 430


Pro Ala Phe Ser Glu Arg Thr Cys Ala Thr Val Thr Ile Gly Gly Ile 
        435                 440                 445


Asn Ile Ala Glu Ala Leu Val Ser Lys Gly Leu Ala Thr Val Ile Arg 
    450                 455                 460


Tyr Arg Gln Asp Asp Asp Gln Arg Ser Ser His Tyr Asp Glu Leu Leu 
465                 470                 475                 480


Ala Ala Glu Ala Arg Ala Ile Lys Asn Gly Lys Gly Leu His Ser Lys 
                485                 490                 495


Lys Glu Val Pro Ile His Arg Val Ala Asp Ile Ser Gly Asp Thr Gln 
            500                 505                 510


Lys Ala Lys Gln Phe Leu Pro Phe Leu Gln Arg Ala Gly Arg Ser Glu 
        515                 520                 525


Ala Val Val Glu Tyr Val Phe Ser Gly Ser Arg Leu Lys Leu Tyr Leu 
    530                 535                 540


Pro Lys Glu Thr Cys Leu Ile Thr Phe Leu Leu Ala Gly Ile Glu Cys 
545                 550                 555                 560


Pro Arg Gly Ala Arg Asn Leu Pro Gly Leu Val Gln Glu Gly Glu Pro 
                565                 570                 575


Phe Ser Glu Glu Ala Thr Leu Phe Thr Lys Glu Leu Val Leu Gln Arg 
            580                 585                 590


Glu Val Glu Val Glu Val Glu Ser Met Asp Lys Ala Gly Asn Phe Ile 
        595                 600                 605


Gly Trp Leu His Ile Asp Gly Ala Asn Leu Ser Val Leu Leu Val Glu 
    610                 615                 620


His Ala Leu Ser Lys Val His Phe Thr Ala Glu Arg Ser Ser Tyr Tyr 
625                 630                 635                 640


Lys Ser Leu Leu Ser Ala Glu Glu Ala Ala Lys Gln Lys Lys Glu Lys 
                645                 650                 655


Val Trp Ala His Tyr Glu Glu Gln Pro Val Glu Glu Val Met Pro Val 
            660                 665                 670


Leu Glu Glu Lys Glu Arg Ser Ala Ser Tyr Lys Pro Val Phe Val Thr 
        675                 680                 685


Glu Ile Thr Asp Asp Leu His Phe Tyr Val Gln Asp Val Glu Thr Gly 
    690                 695                 700


Thr Gln Leu Glu Lys Leu Met Glu Asn Met Arg Asn Asp Ile Ala Ser 
705                 710                 715                 720


His Pro Pro Val Glu Gly Ser Tyr Ala Pro Arg Arg Gly Glu Phe Cys 
                725                 730                 735


Ile Ala Lys Phe Val Asp Gly Glu Trp Tyr Arg Ala Arg Val Glu Lys 
            740                 745                 750


Val Glu Ser Pro Ala Lys Ile His Val Phe Tyr Ile Asp Tyr Gly Asn 
        755                 760                 765


Arg Glu Val Leu Pro Ser Thr Arg Leu Gly Thr Leu Ser Pro Ala Phe 
    770                 775                 780


Ser Thr Arg Val Leu Pro Ala Gln Ala Thr Glu Tyr Ala Phe Ala Phe 
785                 790                 795                 800


Ile Gln Val Pro Gln Asp Asp Asp Ala Arg Thr Asp Ala Val Asp Ser 
                805                 810                 815


Val Val Arg Asp Ile Gln Asn Thr Gln Cys Leu Leu Asn Val Glu His 
            820                 825                 830


Leu Ser Ala Gly Cys Pro His Val Thr Leu Gln Phe Ala Asp Ser Lys 
        835                 840                 845


Gly Asp Val Gly Leu Gly Leu Val Lys Glu Gly Leu Val Met Val Glu 
    850                 855                 860


Val Arg Lys Glu Lys Gln Phe Gln Lys Val Ile Thr Glu Tyr Leu Asn 
865                 870                 875                 880


Ala Gln Glu Ser Ala Lys Ser Ala Arg Leu Asn Leu Trp Arg Tyr Gly 
                885                 890                 895


Asp Phe Arg Ala Asp Asp Ala Asp Glu Phe Gly Tyr Ser Arg 
            900                 905                 910


<210>  507
<211>  3226
<212>  DNA
<213>  Homo sapiens

<400>  507
aggaggaggg ccgggcgggc aggggaggag gaggaggcgg gcgccgtgtc gcacgcagct     60

ccaggcgggg cagccccggt agctgaggga cgcagctaga ccttggcggg acggggcttt    120

cgccggggcc caggcccagg gaccaggcgg aggcgtcgcg ggagcctttg gggcaccaca    180

gagatgcggg tttgcctgca atgagatttc attctctaca tttaaaggac atcctttctg    240

agctgctgtg aataaatttg gaatggtact gtatattttc atctaatgga gaactagctg    300

tactttgaat aaggattgct gcactggacg actttagaac atccctcaca atgtcgtcaa    360

cccggagcca gaacccccac ggcctgaagc agattggcct ggaccagatc tgggacgacc    420

tcagagccgg catccagcag gtgtacacac ggcagagcat ggccaagtcc agatatatgg    480

agctctacac tcatgtttat aactactgta ctagtgttca ccagtcaaac caagcacgag    540

gagctggagt tcctccttct aagtcgaaaa aggggcagac acctggagga gctcagtttg    600

ttggcctgga attatataaa cgacttaagg aatttttgaa gaattacttg acaaatcttc    660

ttaaggatgg agaagatttg atggatgaga gtgtactgaa attctacact caacaatggg    720

aagattatcg attttcaagc aaagtgctga atggaatttg tgcctacctc aatagacatt    780

gggttcgccg tgaatgtgac gaaggacgaa aaggaatata tgaaatctat tcgcttgcat    840

tggtgacttg gagagactgt ctgttcaggc cactgaataa acaggtaaca aatgctgttt    900

taaagctgat tgaaaaggaa aggaatggtg aaaccatcaa tacaagattg attagtggag    960

ttgtacagtc ttacgtggaa ttggggctga atgaagatga tgcatttgca aagggcccta   1020

cgttaacagt gtataaagaa tcctttgaat ctcaattttt ggctgacaca gagagatttt   1080

ataccagaga gagtactgaa ttcttgcagc agaacccagt tactgaatat atgaaaaagg   1140

cagaggctcg tctgcttgag gaacaacgaa gagttcaggt ttaccttcat gaaagcacac   1200

aagatgaatt agcaaggaaa tgtgaacaag tcctcattga aaaacacttg gaaattttcc   1260

acacagaatt tcagaattta ttggatgctg acaaaaatga agatttggga cgcatgtata   1320

atcttgtatc tagaatccag gatggcctag gagaattgaa aaaactgttg gagacacaca   1380

ttcataatca gggtcttgca gccattgaaa agtgtggaga agctgcttta aatgacccca   1440

aaatgtatgt acagacagtg cttgatgttc ataaaaaata caatgccctg gtaatgtctg   1500

cattcaacaa tgacgctggc tttgtggctg ctcttgataa ggcttgtggt cgcttcataa   1560

acaacaacgc ggttaccaag atggcccaat catccagtaa atcccctgag ttgctggctc   1620

gatactgtga ctccttgttg aagaaaagtt ccaagaaccc agaggaggca gaactagaag   1680

acacactcaa tcaagtgatg gttgtcttca agtacataga agacaaagac gtatttcaga   1740

agttctatgc gaagatgctc gccaagaggc tcgtccacca gaacagtgca agtgacgatg   1800

ccgaagccag catgatctcc aagttaaagc aagcttgcgg gttcgagtac acctctaaac   1860

ttcagcgcat gtttcaagac attggcgtga gcaaagatct gaacgagcaa ttcaaaaagc   1920

acttgacaaa ctcagaaccc ctagacttgg atttcagcat tcaagtgctg agctccgggt   1980

cctggccctt ccagcagtct tgtacatttg ccttgccgtc agagttggaa cgtagttatc   2040

agcgattcac agctttctac gccagccgcc acagtggccg aaaattgacg tggttatatc   2100

agttgtctaa aggagaattg gtaactaact gcttcaaaaa cagatatact ttgcaggcgt   2160

cgacattcca gatggctatc ctgcttcagt acaacacgga agatgcctac actgtgcagc   2220

agctgaccga cagcactcaa attaaaatgg acattttggc gcaagtttta cagattttat   2280

taaagtcgaa gctattggtc ttggaagatg aaaatgcaaa tgttgatgag gtggaattga   2340

agccagatac cttaataaaa ttatatcttg gttataaaaa taagaaatta agggttaaca   2400

tcaatgtgcc aatgaaaacc gaacagaagc aggaacaaga aaccacacac aaaaacatcg   2460

aggaagaccg caaactactg attcaggcgg ccatcgtgag aatcatgaag atgaggaagg   2520

ttctgaaaca ccagcagtta cttggcgagg tcctcactca gctgtcctcc aggttcaaac   2580

ctcgagtccc tgtgatcaag aaatgcattg acattctaat tgagaaagaa tatttggagc   2640

gagtggatgg tgaaaaggac acctacagtt acttggctta acccttctgg aagggtctga   2700

ctgtgtgacc cgcagcaaat agttcatgtt ggaaagaatg aaaacaactc aagttcatag   2760

cagccagcct gccgccattg gacctccctt ttaaaaactg agaccaagac tcccatcagc   2820

tggtctcgga tttacatcgg aactgctcag gattgataca tttcaagtct gtaaatacgg   2880

acaccaacgc catttaccct aatttaagaa cagcggggac tgaccctccg tgccgagggc   2940

tgcatgctac cgcactaagt caatacatgg gctccccgat tcgcagctgt cgtcttggca   3000

gcacttgtca cgttggcagc actttgagag caagtctgag tggacccaca tgtaacctgc   3060

tatgaaaacc atttgtatag tgtgtttcat tttttaatgt gtgaaaataa agaaaattaa   3120

aggatttctg tacaagtcgc attgggtttt gttttaagtt ttactaattt ctatatgtaa   3180

ataaaagata taatgattgt gcaaatttaa aaaaaaaaaa aaaaaa                  3226


<210>  508
<211>  776
<212>  PRT
<213>  Homo sapiens

<400>  508

Met Ser Ser Thr Arg Ser Gln Asn Pro His Gly Leu Lys Gln Ile Gly 
1               5                   10                  15


Leu Asp Gln Ile Trp Asp Asp Leu Arg Ala Gly Ile Gln Gln Val Tyr 
            20                  25                  30


Thr Arg Gln Ser Met Ala Lys Ser Arg Tyr Met Glu Leu Tyr Thr His 
        35                  40                  45


Val Tyr Asn Tyr Cys Thr Ser Val His Gln Ser Asn Gln Ala Arg Gly 
    50                  55                  60


Ala Gly Val Pro Pro Ser Lys Ser Lys Lys Gly Gln Thr Pro Gly Gly 
65                  70                  75                  80


Ala Gln Phe Val Gly Leu Glu Leu Tyr Lys Arg Leu Lys Glu Phe Leu 
                85                  90                  95


Lys Asn Tyr Leu Thr Asn Leu Leu Lys Asp Gly Glu Asp Leu Met Asp 
            100                 105                 110


Glu Ser Val Leu Lys Phe Tyr Thr Gln Gln Trp Glu Asp Tyr Arg Phe 
        115                 120                 125


Ser Ser Lys Val Leu Asn Gly Ile Cys Ala Tyr Leu Asn Arg His Trp 
    130                 135                 140


Val Arg Arg Glu Cys Asp Glu Gly Arg Lys Gly Ile Tyr Glu Ile Tyr 
145                 150                 155                 160


Ser Leu Ala Leu Val Thr Trp Arg Asp Cys Leu Phe Arg Pro Leu Asn 
                165                 170                 175


Lys Gln Val Thr Asn Ala Val Leu Lys Leu Ile Glu Lys Glu Arg Asn 
            180                 185                 190


Gly Glu Thr Ile Asn Thr Arg Leu Ile Ser Gly Val Val Gln Ser Tyr 
        195                 200                 205


Val Glu Leu Gly Leu Asn Glu Asp Asp Ala Phe Ala Lys Gly Pro Thr 
    210                 215                 220


Leu Thr Val Tyr Lys Glu Ser Phe Glu Ser Gln Phe Leu Ala Asp Thr 
225                 230                 235                 240


Glu Arg Phe Tyr Thr Arg Glu Ser Thr Glu Phe Leu Gln Gln Asn Pro 
                245                 250                 255


Val Thr Glu Tyr Met Lys Lys Ala Glu Ala Arg Leu Leu Glu Glu Gln 
            260                 265                 270


Arg Arg Val Gln Val Tyr Leu His Glu Ser Thr Gln Asp Glu Leu Ala 
        275                 280                 285


Arg Lys Cys Glu Gln Val Leu Ile Glu Lys His Leu Glu Ile Phe His 
    290                 295                 300


Thr Glu Phe Gln Asn Leu Leu Asp Ala Asp Lys Asn Glu Asp Leu Gly 
305                 310                 315                 320


Arg Met Tyr Asn Leu Val Ser Arg Ile Gln Asp Gly Leu Gly Glu Leu 
                325                 330                 335


Lys Lys Leu Leu Glu Thr His Ile His Asn Gln Gly Leu Ala Ala Ile 
            340                 345                 350


Glu Lys Cys Gly Glu Ala Ala Leu Asn Asp Pro Lys Met Tyr Val Gln 
        355                 360                 365


Thr Val Leu Asp Val His Lys Lys Tyr Asn Ala Leu Val Met Ser Ala 
    370                 375                 380


Phe Asn Asn Asp Ala Gly Phe Val Ala Ala Leu Asp Lys Ala Cys Gly 
385                 390                 395                 400


Arg Phe Ile Asn Asn Asn Ala Val Thr Lys Met Ala Gln Ser Ser Ser 
                405                 410                 415


Lys Ser Pro Glu Leu Leu Ala Arg Tyr Cys Asp Ser Leu Leu Lys Lys 
            420                 425                 430


Ser Ser Lys Asn Pro Glu Glu Ala Glu Leu Glu Asp Thr Leu Asn Gln 
        435                 440                 445


Val Met Val Val Phe Lys Tyr Ile Glu Asp Lys Asp Val Phe Gln Lys 
    450                 455                 460


Phe Tyr Ala Lys Met Leu Ala Lys Arg Leu Val His Gln Asn Ser Ala 
465                 470                 475                 480


Ser Asp Asp Ala Glu Ala Ser Met Ile Ser Lys Leu Lys Gln Ala Cys 
                485                 490                 495


Gly Phe Glu Tyr Thr Ser Lys Leu Gln Arg Met Phe Gln Asp Ile Gly 
            500                 505                 510


Val Ser Lys Asp Leu Asn Glu Gln Phe Lys Lys His Leu Thr Asn Ser 
        515                 520                 525


Glu Pro Leu Asp Leu Asp Phe Ser Ile Gln Val Leu Ser Ser Gly Ser 
    530                 535                 540


Trp Pro Phe Gln Gln Ser Cys Thr Phe Ala Leu Pro Ser Glu Leu Glu 
545                 550                 555                 560


Arg Ser Tyr Gln Arg Phe Thr Ala Phe Tyr Ala Ser Arg His Ser Gly 
                565                 570                 575


Arg Lys Leu Thr Trp Leu Tyr Gln Leu Ser Lys Gly Glu Leu Val Thr 
            580                 585                 590


Asn Cys Phe Lys Asn Arg Tyr Thr Leu Gln Ala Ser Thr Phe Gln Met 
        595                 600                 605


Ala Ile Leu Leu Gln Tyr Asn Thr Glu Asp Ala Tyr Thr Val Gln Gln 
    610                 615                 620


Leu Thr Asp Ser Thr Gln Ile Lys Met Asp Ile Leu Ala Gln Val Leu 
625                 630                 635                 640


Gln Ile Leu Leu Lys Ser Lys Leu Leu Val Leu Glu Asp Glu Asn Ala 
                645                 650                 655


Asn Val Asp Glu Val Glu Leu Lys Pro Asp Thr Leu Ile Lys Leu Tyr 
            660                 665                 670


Leu Gly Tyr Lys Asn Lys Lys Leu Arg Val Asn Ile Asn Val Pro Met 
        675                 680                 685


Lys Thr Glu Gln Lys Gln Glu Gln Glu Thr Thr His Lys Asn Ile Glu 
    690                 695                 700


Glu Asp Arg Lys Leu Leu Ile Gln Ala Ala Ile Val Arg Ile Met Lys 
705                 710                 715                 720


Met Arg Lys Val Leu Lys His Gln Gln Leu Leu Gly Glu Val Leu Thr 
                725                 730                 735


Gln Leu Ser Ser Arg Phe Lys Pro Arg Val Pro Val Ile Lys Lys Cys 
            740                 745                 750


Ile Asp Ile Leu Ile Glu Lys Glu Tyr Leu Glu Arg Val Asp Gly Glu 
        755                 760                 765


Lys Asp Thr Tyr Ser Tyr Leu Ala 
    770                 775


<210>  509
<211>  2695
<212>  DNA
<213>  Homo sapiens

<400>  509
caaataaaag cgatggcgat tgggctgccg cgtttggcgc tcggtccggt cgcgtccgac     60

acccggtggg actcagaagg cagtggagcc ccggcggcgg cggcggcggc gcgcgggggc    120

gacgcgcggg aacaacgcga gtcggcgcgc gggacgaaga ataatcatgg gccagactgg    180

gaagaaatct gagaagggac cagtttgttg gcggaagcgt gtaaaatcag agtacatgcg    240

actgagacag ctcaagaggt tcagacgagc tgatgaagta aagagtatgt ttagttccaa    300

tcgtcagaaa attttggaaa gaacggaaat cttaaaccaa gaatggaaac agcgaaggat    360

acagcctgtg cacatcctga cttctgtgag ctcattgcgc gggactaggg agtgttcggt    420

gaccagtgac ttggattttc caacacaagt catcccatta aagactctga atgcagttgc    480

ttcagtaccc ataatgtatt cttggtctcc cctacagcag aattttatgg tggaagatga    540

aactgtttta cataacattc cttatatggg agatgaagtt ttagatcagg atggtacttt    600

cattgaagaa ctaataaaaa attatgatgg gaaagtacac ggggatagag aatgtgggtt    660

tataaatgat gaaatttttg tggagttggt gaatgccctt ggtcaatata atgatgatga    720

cgatgatgat gatggagacg atcctgaaga aagagaagaa aagcagaaag atctggagga    780

tcaccgagat gataaagaaa gccgcccacc tcggaaattt ccttctgata aaatttttga    840

agccatttcc tcaatgtttc cagataaggg cacagcagaa gaactaaagg aaaaatataa    900

agaactcacc gaacagcagc tcccaggcgc acttcctcct gaatgtaccc ccaacataga    960

tggaccaaat gctaaatctg ttcagagaga gcaaagctta cactcctttc atacgctttt   1020

ctgtaggcga tgttttaaat atgactgctt cctacatcgt aagtgcaatt attcttttca   1080

tgcaacaccc aacacttata agcggaagaa cacagaaaca gctctagaca acaaaccttg   1140

tggaccacag tgttaccagc atttggaggg agcaaaggag tttgctgctg ctctcaccgc   1200

tgagcggata aagaccccac caaaacgtcc aggaggccgc agaagaggac ggcttcccaa   1260

taacagtagc aggcccagca cccccaccat taatgtgctg gaatcaaagg atacagacag   1320

tgatagggaa gcagggactg aaacgggggg agagaacaat gataaagaag aagaagagaa   1380

gaaagatgaa acttcgagct cctctgaagc aaattctcgg tgtcaaacac caataaagat   1440

gaagccaaat attgaacctc ctgagaatgt ggagtggagt ggtgctgaag cctcaatgtt   1500

tagagtcctc attggcactt actatgacaa tttctgtgcc attgctaggt taattgggac   1560

caaaacatgt agacaggtgt atgagtttag agtcaaagaa tctagcatca tagctccagc   1620

tcccgctgag gatgtggata ctcctccaag gaaaaagaag aggaaacacc ggttgtgggc   1680

tgcacactgc agaaagatac agctgaaaaa ggacggctcc tctaaccatg tttacaacta   1740

tcaaccctgt gatcatccac ggcagccttg tgacagttcg tgcccttgtg tgatagcaca   1800

aaatttttgt gaaaagtttt gtcaatgtag ttcagagtgt caaaaccgct ttccgggatg   1860

ccgctgcaaa gcacagtgca acaccaagca gtgcccgtgc tacctggctg tccgagagtg   1920

tgaccctgac ctctgtctta cttgtggagc cgctgaccat tgggacagta aaaatgtgtc   1980

ctgcaagaac tgcagtattc agcggggctc caaaaagcat ctattgctgg caccatctga   2040

cgtggcaggc tgggggattt ttatcaaaga tcctgtgcag aaaaatgaat tcatctcaga   2100

atactgtgga gagattattt ctcaagatga agctgacaga agagggaaag tgtatgataa   2160

atacatgtgc agctttctgt tcaacttgaa caatgatttt gtggtggatg caacccgcaa   2220

gggtaacaaa attcgttttg caaatcattc ggtaaatcca aactgctatg caaaagttat   2280

gatggttaac ggtgatcaca ggataggtat ttttgccaag agagccatcc agactggcga   2340

agagctgttt tttgattaca gatacagcca ggctgatgcc ctgaagtatg tcggcatcga   2400

aagagaaatg gaaatccctt gacatctgct acctcctccc ccctcctctg aaacagctgc   2460

cttagcttca ggaacctcga gtactgtggg caatttagaa aaagaacatg cagtttgaaa   2520

ttctgaattt gcaaagtact gtaagaataa tttatagtaa tgagtttaaa aatcaacttt   2580

ttattgcctt ctcaccagct gcaaagtgtt ttgtaccagt gaatttttgc aataatgcag   2640

tatggtacat ttttcaactt tgaataaaga atacttgaac ttgtcaaaaa aaaaa        2695


<210>  510
<211>  751
<212>  PRT
<213>  Homo sapiens

<400>  510

Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15


Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30


Arg Arg Ala Asp Glu Val Lys Ser Met Phe Ser Ser Asn Arg Gln Lys 
        35                  40                  45


Ile Leu Glu Arg Thr Glu Ile Leu Asn Gln Glu Trp Lys Gln Arg Arg 
    50                  55                  60


Ile Gln Pro Val His Ile Leu Thr Ser Val Ser Ser Leu Arg Gly Thr 
65                  70                  75                  80


Arg Glu Cys Ser Val Thr Ser Asp Leu Asp Phe Pro Thr Gln Val Ile 
                85                  90                  95


Pro Leu Lys Thr Leu Asn Ala Val Ala Ser Val Pro Ile Met Tyr Ser 
            100                 105                 110


Trp Ser Pro Leu Gln Gln Asn Phe Met Val Glu Asp Glu Thr Val Leu 
        115                 120                 125


His Asn Ile Pro Tyr Met Gly Asp Glu Val Leu Asp Gln Asp Gly Thr 
    130                 135                 140


Phe Ile Glu Glu Leu Ile Lys Asn Tyr Asp Gly Lys Val His Gly Asp 
145                 150                 155                 160


Arg Glu Cys Gly Phe Ile Asn Asp Glu Ile Phe Val Glu Leu Val Asn 
                165                 170                 175


Ala Leu Gly Gln Tyr Asn Asp Asp Asp Asp Asp Asp Asp Gly Asp Asp 
            180                 185                 190


Pro Glu Glu Arg Glu Glu Lys Gln Lys Asp Leu Glu Asp His Arg Asp 
        195                 200                 205


Asp Lys Glu Ser Arg Pro Pro Arg Lys Phe Pro Ser Asp Lys Ile Phe 
    210                 215                 220


Glu Ala Ile Ser Ser Met Phe Pro Asp Lys Gly Thr Ala Glu Glu Leu 
225                 230                 235                 240


Lys Glu Lys Tyr Lys Glu Leu Thr Glu Gln Gln Leu Pro Gly Ala Leu 
                245                 250                 255


Pro Pro Glu Cys Thr Pro Asn Ile Asp Gly Pro Asn Ala Lys Ser Val 
            260                 265                 270


Gln Arg Glu Gln Ser Leu His Ser Phe His Thr Leu Phe Cys Arg Arg 
        275                 280                 285


Cys Phe Lys Tyr Asp Cys Phe Leu His Arg Lys Cys Asn Tyr Ser Phe 
    290                 295                 300


His Ala Thr Pro Asn Thr Tyr Lys Arg Lys Asn Thr Glu Thr Ala Leu 
305                 310                 315                 320


Asp Asn Lys Pro Cys Gly Pro Gln Cys Tyr Gln His Leu Glu Gly Ala 
                325                 330                 335


Lys Glu Phe Ala Ala Ala Leu Thr Ala Glu Arg Ile Lys Thr Pro Pro 
            340                 345                 350


Lys Arg Pro Gly Gly Arg Arg Arg Gly Arg Leu Pro Asn Asn Ser Ser 
        355                 360                 365


Arg Pro Ser Thr Pro Thr Ile Asn Val Leu Glu Ser Lys Asp Thr Asp 
    370                 375                 380


Ser Asp Arg Glu Ala Gly Thr Glu Thr Gly Gly Glu Asn Asn Asp Lys 
385                 390                 395                 400


Glu Glu Glu Glu Lys Lys Asp Glu Thr Ser Ser Ser Ser Glu Ala Asn 
                405                 410                 415


Ser Arg Cys Gln Thr Pro Ile Lys Met Lys Pro Asn Ile Glu Pro Pro 
            420                 425                 430


Glu Asn Val Glu Trp Ser Gly Ala Glu Ala Ser Met Phe Arg Val Leu 
        435                 440                 445


Ile Gly Thr Tyr Tyr Asp Asn Phe Cys Ala Ile Ala Arg Leu Ile Gly 
    450                 455                 460


Thr Lys Thr Cys Arg Gln Val Tyr Glu Phe Arg Val Lys Glu Ser Ser 
465                 470                 475                 480


Ile Ile Ala Pro Ala Pro Ala Glu Asp Val Asp Thr Pro Pro Arg Lys 
                485                 490                 495


Lys Lys Arg Lys His Arg Leu Trp Ala Ala His Cys Arg Lys Ile Gln 
            500                 505                 510


Leu Lys Lys Asp Gly Ser Ser Asn His Val Tyr Asn Tyr Gln Pro Cys 
        515                 520                 525


Asp His Pro Arg Gln Pro Cys Asp Ser Ser Cys Pro Cys Val Ile Ala 
    530                 535                 540


Gln Asn Phe Cys Glu Lys Phe Cys Gln Cys Ser Ser Glu Cys Gln Asn 
545                 550                 555                 560


Arg Phe Pro Gly Cys Arg Cys Lys Ala Gln Cys Asn Thr Lys Gln Cys 
                565                 570                 575


Pro Cys Tyr Leu Ala Val Arg Glu Cys Asp Pro Asp Leu Cys Leu Thr 
            580                 585                 590


Cys Gly Ala Ala Asp His Trp Asp Ser Lys Asn Val Ser Cys Lys Asn 
        595                 600                 605


Cys Ser Ile Gln Arg Gly Ser Lys Lys His Leu Leu Leu Ala Pro Ser 
    610                 615                 620


Asp Val Ala Gly Trp Gly Ile Phe Ile Lys Asp Pro Val Gln Lys Asn 
625                 630                 635                 640


Glu Phe Ile Ser Glu Tyr Cys Gly Glu Ile Ile Ser Gln Asp Glu Ala 
                645                 650                 655


Asp Arg Arg Gly Lys Val Tyr Asp Lys Tyr Met Cys Ser Phe Leu Phe 
            660                 665                 670


Asn Leu Asn Asn Asp Phe Val Val Asp Ala Thr Arg Lys Gly Asn Lys 
        675                 680                 685


Ile Arg Phe Ala Asn His Ser Val Asn Pro Asn Cys Tyr Ala Lys Val 
    690                 695                 700


Met Met Val Asn Gly Asp His Arg Ile Gly Ile Phe Ala Lys Arg Ala 
705                 710                 715                 720


Ile Gln Thr Gly Glu Glu Leu Phe Phe Asp Tyr Arg Tyr Ser Gln Ala 
                725                 730                 735


Asp Ala Leu Lys Tyr Val Gly Ile Glu Arg Glu Met Glu Ile Pro 
            740                 745                 750


<210>  511
<211>  2563
<212>  DNA
<213>  Homo sapiens

<400>  511
caaataaaag cgatggcgat tgggctgccg cgtttggcgc tcggtccggt cgcgtccgac     60

acccggtggg actcagaagg cagtggagcc ccggcggcgg cggcggcggc gcgcgggggc    120

gacgcgcggg aacaacgcga gtcggcgcgc gggacgaaga ataatcatgg gccagactgg    180

gaagaaatct gagaagggac cagtttgttg gcggaagcgt gtaaaatcag agtacatgcg    240

actgagacag ctcaagaggt tcagacgagc tgatgaagta aagagtatgt ttagttccaa    300

tcgtcagaaa attttggaaa gaacggaaat cttaaaccaa gaatggaaac agcgaaggat    360

acagcctgtg cacatcctga cttctgtgag ctcattgcgc gggactaggg aggtggaaga    420

tgaaactgtt ttacataaca ttccttatat gggagatgaa gttttagatc aggatggtac    480

tttcattgaa gaactaataa aaaattatga tgggaaagta cacggggata gagaatgtgg    540

gtttataaat gatgaaattt ttgtggagtt ggtgaatgcc cttggtcaat ataatgatga    600

tgacgatgat gatgatggag acgatcctga agaaagagaa gaaaagcaga aagatctgga    660

ggatcaccga gatgataaag aaagccgccc acctcggaaa tttccttctg ataaaatttt    720

tgaagccatt tcctcaatgt ttccagataa gggcacagca gaagaactaa aggaaaaata    780

taaagaactc accgaacagc agctcccagg cgcacttcct cctgaatgta cccccaacat    840

agatggacca aatgctaaat ctgttcagag agagcaaagc ttacactcct ttcatacgct    900

tttctgtagg cgatgtttta aatatgactg cttcctacat ccttttcatg caacacccaa    960

cacttataag cggaagaaca cagaaacagc tctagacaac aaaccttgtg gaccacagtg   1020

ttaccagcat ttggagggag caaaggagtt tgctgctgct ctcaccgctg agcggataaa   1080

gaccccacca aaacgtccag gaggccgcag aagaggacgg cttcccaata acagtagcag   1140

gcccagcacc cccaccatta atgtgctgga atcaaaggat acagacagtg atagggaagc   1200

agggactgaa acggggggag agaacaatga taaagaagaa gaagagaaga aagatgaaac   1260

ttcgagctcc tctgaagcaa attctcggtg tcaaacacca ataaagatga agccaaatat   1320

tgaacctcct gagaatgtgg agtggagtgg tgctgaagcc tcaatgttta gagtcctcat   1380

tggcacttac tatgacaatt tctgtgccat tgctaggtta attgggacca aaacatgtag   1440

acaggtgtat gagtttagag tcaaagaatc tagcatcata gctccagctc ccgctgagga   1500

tgtggatact cctccaagga aaaagaagag gaaacaccgg ttgtgggctg cacactgcag   1560

aaagatacag ctgaaaaagg acggctcctc taaccatgtt tacaactatc aaccctgtga   1620

tcatccacgg cagccttgtg acagttcgtg cccttgtgtg atagcacaaa atttttgtga   1680

aaagttttgt caatgtagtt cagagtgtca aaaccgcttt ccgggatgcc gctgcaaagc   1740

acagtgcaac accaagcagt gcccgtgcta cctggctgtc cgagagtgtg accctgacct   1800

ctgtcttact tgtggagccg ctgaccattg ggacagtaaa aatgtgtcct gcaagaactg   1860

cagtattcag cggggctcca aaaagcatct attgctggca ccatctgacg tggcaggctg   1920

ggggattttt atcaaagatc ctgtgcagaa aaatgaattc atctcagaat actgtggaga   1980

gattatttct caagatgaag ctgacagaag agggaaagtg tatgataaat acatgtgcag   2040

ctttctgttc aacttgaaca atgattttgt ggtggatgca acccgcaagg gtaacaaaat   2100

tcgttttgca aatcattcgg taaatccaaa ctgctatgca aaagttatga tggttaacgg   2160

tgatcacagg ataggtattt ttgccaagag agccatccag actggcgaag agctgttttt   2220

tgattacaga tacagccagg ctgatgccct gaagtatgtc ggcatcgaaa gagaaatgga   2280

aatcccttga catctgctac ctcctccccc ctcctctgaa acagctgcct tagcttcagg   2340

aacctcgagt actgtgggca atttagaaaa agaacatgca gtttgaaatt ctgaatttgc   2400

aaagtactgt aagaataatt tatagtaatg agtttaaaaa tcaacttttt attgccttct   2460

caccagctgc aaagtgtttt gtaccagtga atttttgcaa taatgcagta tggtacattt   2520

ttcaactttg aataaagaat acttgaactt gtcaaaaaaa aaa                     2563


<210>  512
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  512

Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15


Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30


Arg Arg Ala Asp Glu Val Lys Ser Met Phe Ser Ser Asn Arg Gln Lys 
        35                  40                  45


Ile Leu Glu Arg Thr Glu Ile Leu Asn Gln Glu Trp Lys Gln Arg Arg 
    50                  55                  60


Ile Gln Pro Val His Ile Leu Thr Ser Val Ser Ser Leu Arg Gly Thr 
65                  70                  75                  80


Arg Glu Val Glu Asp Glu Thr Val Leu His Asn Ile Pro Tyr Met Gly 
                85                  90                  95


Asp Glu Val Leu Asp Gln Asp Gly Thr Phe Ile Glu Glu Leu Ile Lys 
            100                 105                 110


Asn Tyr Asp Gly Lys Val His Gly Asp Arg Glu Cys Gly Phe Ile Asn 
        115                 120                 125


Asp Glu Ile Phe Val Glu Leu Val Asn Ala Leu Gly Gln Tyr Asn Asp 
    130                 135                 140


Asp Asp Asp Asp Asp Asp Gly Asp Asp Pro Glu Glu Arg Glu Glu Lys 
145                 150                 155                 160


Gln Lys Asp Leu Glu Asp His Arg Asp Asp Lys Glu Ser Arg Pro Pro 
                165                 170                 175


Arg Lys Phe Pro Ser Asp Lys Ile Phe Glu Ala Ile Ser Ser Met Phe 
            180                 185                 190


Pro Asp Lys Gly Thr Ala Glu Glu Leu Lys Glu Lys Tyr Lys Glu Leu 
        195                 200                 205


Thr Glu Gln Gln Leu Pro Gly Ala Leu Pro Pro Glu Cys Thr Pro Asn 
    210                 215                 220


Ile Asp Gly Pro Asn Ala Lys Ser Val Gln Arg Glu Gln Ser Leu His 
225                 230                 235                 240


Ser Phe His Thr Leu Phe Cys Arg Arg Cys Phe Lys Tyr Asp Cys Phe 
                245                 250                 255


Leu His Pro Phe His Ala Thr Pro Asn Thr Tyr Lys Arg Lys Asn Thr 
            260                 265                 270


Glu Thr Ala Leu Asp Asn Lys Pro Cys Gly Pro Gln Cys Tyr Gln His 
        275                 280                 285


Leu Glu Gly Ala Lys Glu Phe Ala Ala Ala Leu Thr Ala Glu Arg Ile 
    290                 295                 300


Lys Thr Pro Pro Lys Arg Pro Gly Gly Arg Arg Arg Gly Arg Leu Pro 
305                 310                 315                 320


Asn Asn Ser Ser Arg Pro Ser Thr Pro Thr Ile Asn Val Leu Glu Ser 
                325                 330                 335


Lys Asp Thr Asp Ser Asp Arg Glu Ala Gly Thr Glu Thr Gly Gly Glu 
            340                 345                 350


Asn Asn Asp Lys Glu Glu Glu Glu Lys Lys Asp Glu Thr Ser Ser Ser 
        355                 360                 365


Ser Glu Ala Asn Ser Arg Cys Gln Thr Pro Ile Lys Met Lys Pro Asn 
    370                 375                 380


Ile Glu Pro Pro Glu Asn Val Glu Trp Ser Gly Ala Glu Ala Ser Met 
385                 390                 395                 400


Phe Arg Val Leu Ile Gly Thr Tyr Tyr Asp Asn Phe Cys Ala Ile Ala 
                405                 410                 415


Arg Leu Ile Gly Thr Lys Thr Cys Arg Gln Val Tyr Glu Phe Arg Val 
            420                 425                 430


Lys Glu Ser Ser Ile Ile Ala Pro Ala Pro Ala Glu Asp Val Asp Thr 
        435                 440                 445


Pro Pro Arg Lys Lys Lys Arg Lys His Arg Leu Trp Ala Ala His Cys 
    450                 455                 460


Arg Lys Ile Gln Leu Lys Lys Asp Gly Ser Ser Asn His Val Tyr Asn 
465                 470                 475                 480


Tyr Gln Pro Cys Asp His Pro Arg Gln Pro Cys Asp Ser Ser Cys Pro 
                485                 490                 495


Cys Val Ile Ala Gln Asn Phe Cys Glu Lys Phe Cys Gln Cys Ser Ser 
            500                 505                 510


Glu Cys Gln Asn Arg Phe Pro Gly Cys Arg Cys Lys Ala Gln Cys Asn 
        515                 520                 525


Thr Lys Gln Cys Pro Cys Tyr Leu Ala Val Arg Glu Cys Asp Pro Asp 
    530                 535                 540


Leu Cys Leu Thr Cys Gly Ala Ala Asp His Trp Asp Ser Lys Asn Val 
545                 550                 555                 560


Ser Cys Lys Asn Cys Ser Ile Gln Arg Gly Ser Lys Lys His Leu Leu 
                565                 570                 575


Leu Ala Pro Ser Asp Val Ala Gly Trp Gly Ile Phe Ile Lys Asp Pro 
            580                 585                 590


Val Gln Lys Asn Glu Phe Ile Ser Glu Tyr Cys Gly Glu Ile Ile Ser 
        595                 600                 605


Gln Asp Glu Ala Asp Arg Arg Gly Lys Val Tyr Asp Lys Tyr Met Cys 
    610                 615                 620


Ser Phe Leu Phe Asn Leu Asn Asn Asp Phe Val Val Asp Ala Thr Arg 
625                 630                 635                 640


Lys Gly Asn Lys Ile Arg Phe Ala Asn His Ser Val Asn Pro Asn Cys 
                645                 650                 655


Tyr Ala Lys Val Met Met Val Asn Gly Asp His Arg Ile Gly Ile Phe 
            660                 665                 670


Ala Lys Arg Ala Ile Gln Thr Gly Glu Glu Leu Phe Phe Asp Tyr Arg 
        675                 680                 685


Tyr Ser Gln Ala Asp Ala Leu Lys Tyr Val Gly Ile Glu Arg Glu Met 
    690                 695                 700


Glu Ile Pro 
705


<210>  513
<211>  901
<212>  DNA
<213>  Homo sapiens

<400>  513
cccaaagtac ttgtgtccgg gtggtggact ggattagctg cggagccctg gaagctgcct     60

gtccttctcc ctgtgcttaa ccagaggtgc ccatgggttg gacaatgagg ctggtcacag    120

cagcactgtt actgggtctc atgatggtgg tcactggaga cgaggatgag aacagcccgt    180

gtgcccatga ggccctcttg gacgaggaca ccctcttttg ccagggcctt gaagttttct    240

acccagagtt ggggaacatt ggctgcaagg ttgttcctga ttgtaacaac tacagacaga    300

agatcacctc ctggatggag ccgatagtca agttcccggg ggccgtggac ggcgcaacct    360

atatcctggt gatggtggat ccagatgccc ctagcagagc agaacccaga cagagattct    420

ggagacattg gctggtaaca gatatcaagg gcgccgacct gaagaaaggg aagattcagg    480

gccaggagtt atcagcctac caggctccct ccccaccggc acacagtggc ttccatcgct    540

accagttctt tgtctatctt caggaaggaa aagtcatctc tctccttccc aaggaaaaca    600

aaactcgagg ctcttggaaa atggacagat ttctgaaccg tttccacctg ggcgaacctg    660

aagcaagcac ccagttcatg acccagaact accaggactc accaaccctc caggctccca    720

gagaaagggc cagcgagccc aagcacaaaa accaggcgga gatagctgcc tgctagatag    780

ccggctttgc catccgggca tgtggccaca ctgcccacca ccgacgatgt gggtatggaa    840

ccccctctgg atacagaacc ccttcttttc caaataaaaa aaaaatcatc caggaaaaaa    900

a                                                                    901


<210>  514
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  514

Met Gly Trp Thr Met Arg Leu Val Thr Ala Ala Leu Leu Leu Gly Leu 
1               5                   10                  15


Met Met Val Val Thr Gly Asp Glu Asp Glu Asn Ser Pro Cys Ala His 
            20                  25                  30


Glu Ala Leu Leu Asp Glu Asp Thr Leu Phe Cys Gln Gly Leu Glu Val 
        35                  40                  45


Phe Tyr Pro Glu Leu Gly Asn Ile Gly Cys Lys Val Val Pro Asp Cys 
    50                  55                  60


Asn Asn Tyr Arg Gln Lys Ile Thr Ser Trp Met Glu Pro Ile Val Lys 
65                  70                  75                  80


Phe Pro Gly Ala Val Asp Gly Ala Thr Tyr Ile Leu Val Met Val Asp 
                85                  90                  95


Pro Asp Ala Pro Ser Arg Ala Glu Pro Arg Gln Arg Phe Trp Arg His 
            100                 105                 110


Trp Leu Val Thr Asp Ile Lys Gly Ala Asp Leu Lys Lys Gly Lys Ile 
        115                 120                 125


Gln Gly Gln Glu Leu Ser Ala Tyr Gln Ala Pro Ser Pro Pro Ala His 
    130                 135                 140


Ser Gly Phe His Arg Tyr Gln Phe Phe Val Tyr Leu Gln Glu Gly Lys 
145                 150                 155                 160


Val Ile Ser Leu Leu Pro Lys Glu Asn Lys Thr Arg Gly Ser Trp Lys 
                165                 170                 175


Met Asp Arg Phe Leu Asn Arg Phe His Leu Gly Glu Pro Glu Ala Ser 
            180                 185                 190


Thr Gln Phe Met Thr Gln Asn Tyr Gln Asp Ser Pro Thr Leu Gln Ala 
        195                 200                 205


Pro Arg Glu Arg Ala Ser Glu Pro Lys His Lys Asn Gln Ala Glu Ile 
    210                 215                 220


Ala Ala Cys 
225


<210>  515
<211>  2709
<212>  DNA
<213>  Homo sapiens

<400>  515
ctttctcgcg gcgctgcaac cctcccacca cagcccatcc agccccgccc agcgcgccgc     60

ggtgcgcatg cgtggaggcc ctcgctgccg ctgagcacct cgggaagtgt agtctcttcg    120

caggtgcggc tgggcagcta gagtcctgca tcccggtgga atccggagaa gtgagaacat    180

tcccgccgcc cggtcctcat tcccatcttc ccacctgtcc agtcccctcg cactcccgct    240

gcaccccacg cgccgggctt cagtcagaga gtgcactgag gaagagcgga gaccccctct    300

tcccctcagc aggctgtgcc gggggaggcg gggtccaccg cccgcccccc gccgtcgctc    360

tccccgcctc cccttccctc ccctcctggc gggtgcgggg ccggtgtccg aagtcaggcg    420

gcggcccccg cagcggccgc aggaggggcg gctgcggtgg gcgccgcggg cgatgcccct    480

gcccggctgc tccggcgggg ggcagtgcga gcggcggcgg cgggggagga ggcggggggc    540

ggcggctgcg gcggctgcag cagaggggcc gagagctggc ggtggcggcg gcggtggtcg    600

tgaagggcat cggcggcggc ggtgatggca gagatgatgt gagtgcccgc cggctggaga    660

cctggggccg cggagcgcgg gacgggcggc ggcggcgtgc gggagcggcc ccgggggcgg    720

cggagggatg cggggagcgc gggcagagcc ggagcggcgg ccgccaaccg gccggcagtg    780

gctggagccc cgcgctgcgg cgccggggga gccgggcccg gcgtgggggt cgcgggcggc    840

ggcggggcgg tcaggccgag gggcgtctgc gattgttctc aacacccctc ccccacccca    900

tcccgtgtgt ctgtttgtta cttgcagctg aagatggaaa gagccaggcg aaggggaggc    960

ggcggcggcc gcggccgcgg aggcaagaat gtagggggct ctggcctaag caagagtaga   1020

ctctatcccc aggcccagca ctcccactac ccccactacg cggcctcagc cacccctaat   1080

caggccgggg gcgcagccga aatccaggag ctggcctcca aacgagtgga catccagaaa   1140

aagaggtttt acctagacgt gaagcaaagc tcccggggcc gcttcctaaa gatagccgaa   1200

gtctggatag ggagaggccg gcaggacaac atcagaaaga gtaaactgac cctctccctg   1260

tctgtggcag cggagctgaa ggactgtcta ggggacttca tcgagcacta tgcccacctg   1320

ggcctgaaag gccaccggca agagcatggc cacagcaaag agcaaggctc cagaaggagg   1380

cagaagcact cggcaccctc cccaccagtc tcggtggggt ccgaagagca tcctcacagt   1440

gtcctgaaaa cagactatat cgagagggac aataggaaat attacctaga cctaaaggaa   1500

aatcagcggg gtcgcttcct acggattaga caaaccatga tgcgggggac tggcatgata   1560

ggttattttg gccacagttt gggccaagaa cagactattg tcctcccagc acaaggaatg   1620

attgagtttc gtgatgcctt ggttcagctg attgaagact atggcgaagg agacatagaa   1680

gaacgaagag gtggagacga tgacccgctt gaactcccag aggggacttc tttcagagtg   1740

gacaataaaa ggttctactt tgatgtgggc tctaataaat atggaatttt cctgaagctc   1800

acaaattacc ccaaatccag agagaatatc aacctttttc actgttgtca aatcaagcat   1860

aaggaacagc cccatgatac tacaaaaaca gttgaggaat aaggaataaa tctcttatgt   1920

tacacctcag aataaaggca ttcggtgaaa gaaatgaact gaagttcatc atgaatgcaa   1980

ggcctcagta cttgacattc ctccacggaa gggaagacaa gtatcaacac cactggcatc   2040

atttccaaac tgatcttatg ttgaataatt tccaccacat tgaagtacct ttcgactcta   2100

tccagttttt gggttttgtt ttttttaatt catcaagcct ttcgttttca aaccaccatt   2160

tgtcagcctt gaggtagaga gacatataga tttgaaaata ctttcttaag agatcatgta   2220

actatataac tctgaattta aaaattgagg ggggagggat aatttcaacc cactgcctct   2280

taccagaaac atttttttaa atctgtaact gctttagtgt taacagggtg caaggtggtt   2340

tttgtcccgt attgttctta aaaggttctc atttattgtg attgtattgt actgtatgag   2400

aacaaatcat aaattgcctt gtattgttta taatagacca taccacgtac tacttcagtt   2460

tttatgttcc aagtttttca gtgatgcatg ttaacagtta ggtcctaaaa ttctgtggtg   2520

ctaattctcc catacccaat ggtgcttttg tggatgctaa ctgcacacat gctgaacaaa   2580

gcttgaagtt taaaactttc ctcccttcct ctgtttatat gaagtaaaat gaaataactt   2640

gaatttgtct caaagtatca ctgacaatct aataaacttg tttatatgtg aaaaaaaaaa   2700

aaaaaaaaa                                                           2709


<210>  516
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  516

Met Glu Arg Ala Arg Arg Arg Gly Gly Gly Gly Gly Arg Gly Arg Gly 
1               5                   10                  15


Gly Lys Asn Val Gly Gly Ser Gly Leu Ser Lys Ser Arg Leu Tyr Pro 
            20                  25                  30


Gln Ala Gln His Ser His Tyr Pro His Tyr Ala Ala Ser Ala Thr Pro 
        35                  40                  45


Asn Gln Ala Gly Gly Ala Ala Glu Ile Gln Glu Leu Ala Ser Lys Arg 
    50                  55                  60


Val Asp Ile Gln Lys Lys Arg Phe Tyr Leu Asp Val Lys Gln Ser Ser 
65                  70                  75                  80


Arg Gly Arg Phe Leu Lys Ile Ala Glu Val Trp Ile Gly Arg Gly Arg 
                85                  90                  95


Gln Asp Asn Ile Arg Lys Ser Lys Leu Thr Leu Ser Leu Ser Val Ala 
            100                 105                 110


Ala Glu Leu Lys Asp Cys Leu Gly Asp Phe Ile Glu His Tyr Ala His 
        115                 120                 125


Leu Gly Leu Lys Gly His Arg Gln Glu His Gly His Ser Lys Glu Gln 
    130                 135                 140


Gly Ser Arg Arg Arg Gln Lys His Ser Ala Pro Ser Pro Pro Val Ser 
145                 150                 155                 160


Val Gly Ser Glu Glu His Pro His Ser Val Leu Lys Thr Asp Tyr Ile 
                165                 170                 175


Glu Arg Asp Asn Arg Lys Tyr Tyr Leu Asp Leu Lys Glu Asn Gln Arg 
            180                 185                 190


Gly Arg Phe Leu Arg Ile Arg Gln Thr Met Met Arg Gly Thr Gly Met 
        195                 200                 205


Ile Gly Tyr Phe Gly His Ser Leu Gly Gln Glu Gln Thr Ile Val Leu 
    210                 215                 220


Pro Ala Gln Gly Met Ile Glu Phe Arg Asp Ala Leu Val Gln Leu Ile 
225                 230                 235                 240


Glu Asp Tyr Gly Glu Gly Asp Ile Glu Glu Arg Arg Gly Gly Asp Asp 
                245                 250                 255


Asp Pro Leu Glu Leu Pro Glu Gly Thr Ser Phe Arg Val Asp Asn Lys 
            260                 265                 270


Arg Phe Tyr Phe Asp Val Gly Ser Asn Lys Tyr Gly Ile Phe Leu Lys 
        275                 280                 285


Leu Thr Asn Tyr Pro Lys Ser Arg Glu Asn Ile Asn Leu Phe His Cys 
    290                 295                 300


Cys Gln Ile Lys His Lys Glu Gln Pro His Asp Thr Thr Lys Thr Val 
305                 310                 315                 320


Glu Glu 



<210>  517
<211>  1972
<212>  DNA
<213>  Homo sapiens

<400>  517
ttgttacttg cagctgaaga tggaaagagc caggcgaagg ggaggcggcg gcggccgcgg     60

ccgcggaggc aagaatgtag ggggctctgg cctaagcaag agtagactct atccccaggc    120

ccagcactcc cactaccccc actacgcggc ctcagccacc cctaatcagg ccgggggcgc    180

agccgaaatc caggagctgg cctccaaacg agtggacatc cagaaaaaga ggttttacct    240

agacgtgaag caaagctccc ggggccgctt cctaaagata gccgaagtct ggatagggag    300

aggccggcag gacaacatca gaaagagtaa actgaccctc tccctgtctg tggcagcgga    360

gctgaaggac tgtctagggg acttcatcga gcactatgcc cacctgggcc tgaaaggcca    420

ccggcaagag catggccaca gcaaagagca aggctccaga aggaggcaga agcactcggc    480

accctcccca ccagtctcgg tggggtccga agagcatcct cacagtgtcc tgaaaacaga    540

ctatatcgag agggacaata ggaaatatta cctagaccta aaggaaaatc agcggggtcg    600

cttcctacgg attagacaaa ccatgatgcg ggggactggc atgataggtt attttggcca    660

cagtttgggc caagaacaga ctattgtcct cccagcacaa ggaatgattg agtttcgtga    720

tgccttggtt cagctgattg aagactatgg cgaaggagac atagaagaac gaagaggtgg    780

agacgatgac ccgcttgaac tcccagaggg gacttctttc agagtggaca ataaaaggtt    840

ctactttgat gtgggctcta ataaatatgg aattttcctg aaggtaagtg aggtgagacc    900

accttaccgt aatactatta ctgttccatt caaagcttgg acaaggtttg gggagaattt    960

tatcaagtat gaagaagaga tgaggaaaat ttgcaacagc cataaagaaa agagaatgga   1020

tggcagaaag gccagtggtg aagaacaaga atgcctcgac tagagtgaaa ttgaactcca   1080

tcaggcaaaa tttaaaatca caaattggct aaaagtactg atccattatc ctttgaagaa   1140

gtttttcctc ttttttggcc cgttgttatt agtaatacct ctagtagttg atacttcagg   1200

aagtctgatt ctcatgttat gttacacata gatcactata attcttacgg gaattccaac   1260

cttcccagag ctaaatagtt tagctgcttc aactgctcca gactattgaa gtatgcaaat   1320

cagcacaaaa tgtgacattc tgacattcta aataccataa ctaagattta cattgcacta   1380

tgacataatc ccgaaaaaag atacatatac ttaaatagaa gtgtgacttt cccccaaaag   1440

tatttcaatt ctacttcatt aaaagctgct aagcttacct gtagggcagt taccacagaa   1500

acagaaattg acctccggta tatataaata tttacttata aaagtacaag tagacgtata   1560

ttgtccgttg aataactgaa tataccatca aaggatcaaa tcttattacc taattaaacc   1620

ttaaaaatat aatgtcataa tatttcttaa gaatactata gtattctata atttcaaact   1680

ttgtggtaac cctacatttt atagttgcca tatcaaagcc atgggagagt tttaattcgt   1740

tattctaagt ttagttacaa tcccttcttt acctctactt aatgttccat atatttttat   1800

tgactttcca aagtttcagg aattactttt atgtcacatt gagtgggagg cttcatccaa   1860

tggctttgct atggaaatct tggtggtgta gcttttcatg ctaatttaaa gattgcaaga   1920

ggtttcttcc ccaaaatata tcatggactc aaggtgttat aaaaaaaaaa aa           1972


<210>  518
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  518

Met Glu Arg Ala Arg Arg Arg Gly Gly Gly Gly Gly Arg Gly Arg Gly 
1               5                   10                  15


Gly Lys Asn Val Gly Gly Ser Gly Leu Ser Lys Ser Arg Leu Tyr Pro 
            20                  25                  30


Gln Ala Gln His Ser His Tyr Pro His Tyr Ala Ala Ser Ala Thr Pro 
        35                  40                  45


Asn Gln Ala Gly Gly Ala Ala Glu Ile Gln Glu Leu Ala Ser Lys Arg 
    50                  55                  60


Val Asp Ile Gln Lys Lys Arg Phe Tyr Leu Asp Val Lys Gln Ser Ser 
65                  70                  75                  80


Arg Gly Arg Phe Leu Lys Ile Ala Glu Val Trp Ile Gly Arg Gly Arg 
                85                  90                  95


Gln Asp Asn Ile Arg Lys Ser Lys Leu Thr Leu Ser Leu Ser Val Ala 
            100                 105                 110


Ala Glu Leu Lys Asp Cys Leu Gly Asp Phe Ile Glu His Tyr Ala His 
        115                 120                 125


Leu Gly Leu Lys Gly His Arg Gln Glu His Gly His Ser Lys Glu Gln 
    130                 135                 140


Gly Ser Arg Arg Arg Gln Lys His Ser Ala Pro Ser Pro Pro Val Ser 
145                 150                 155                 160


Val Gly Ser Glu Glu His Pro His Ser Val Leu Lys Thr Asp Tyr Ile 
                165                 170                 175


Glu Arg Asp Asn Arg Lys Tyr Tyr Leu Asp Leu Lys Glu Asn Gln Arg 
            180                 185                 190


Gly Arg Phe Leu Arg Ile Arg Gln Thr Met Met Arg Gly Thr Gly Met 
        195                 200                 205


Ile Gly Tyr Phe Gly His Ser Leu Gly Gln Glu Gln Thr Ile Val Leu 
    210                 215                 220


Pro Ala Gln Gly Met Ile Glu Phe Arg Asp Ala Leu Val Gln Leu Ile 
225                 230                 235                 240


Glu Asp Tyr Gly Glu Gly Asp Ile Glu Glu Arg Arg Gly Gly Asp Asp 
                245                 250                 255


Asp Pro Leu Glu Leu Pro Glu Gly Thr Ser Phe Arg Val Asp Asn Lys 
            260                 265                 270


Arg Phe Tyr Phe Asp Val Gly Ser Asn Lys Tyr Gly Ile Phe Leu Lys 
        275                 280                 285


Val Ser Glu Val Arg Pro Pro Tyr Arg Asn Thr Ile Thr Val Pro Phe 
    290                 295                 300


Lys Ala Trp Thr Arg Phe Gly Glu Asn Phe Ile Lys Tyr Glu Glu Glu 
305                 310                 315                 320


Met Arg Lys Ile Cys Asn Ser His Lys Glu Lys Arg Met Asp Gly Arg 
                325                 330                 335


Lys Ala Ser Gly Glu Glu Gln Glu Cys Leu Asp 
            340                 345


<210>  519
<211>  5745
<212>  DNA
<213>  Homo sapiens

<400>  519
cagccgcccc tcctgcggcc gctgcggggg ccgccgcctg acttcggaca ccggccccgc     60

acccgccagg aggggaggga aggggaggcg gggagagcga cggcgggggg cgggcggtgg    120

accccgcctc ccccggcaca gcctgctgag gggaagaggg ggtctccgct cttcctcagt    180

gcactctctg actgaagccc ggcgcgtggg gtgcagcggg agtgcgaggg gactggacag    240

gtgggaagat gggaatgagg accgggcggc gggaatgttc tcacttctcc ggattccacc    300

gggatgcagg actctagctg cccagccgca cctgcgaaga gactacactt cccgaggtgc    360

tcagcggcag cgagggcctc cacgcatgcg caccgcggcg cgctgggcgg ggctggatgg    420

gctgtggtgg gagggttgca gcgccgcgag aaaggcgagc cgggccgggg gcggggaaag    480

gggtggggca ggaacggggg cggggacggc gctggagggg cgggtcgggt aggtctcccg    540

gagctgatgt gtactgtgtg cgccggggag gcgccggctt gtactcggca gcgcgggaat    600

aaagtttgct gatttggtgt ctagcctgga tgcctgggtt gcaggccctg cttgtggtgg    660

cgctccacag tcatccggct gaagaagacc tgttggactg gatcttctcg ggttttcttt    720

cagatattgt tttgtattta cccatgaaga cattgttttt tggactctgc aaataggaca    780

tttcaaagat gagtgaaaaa aaattggaaa caactgcaca gcagcggaaa tgtcctgaat    840

ggatgaatgt gcagaataaa agatgtgctg tagaagaaag aaaggcatgt gttcggaaga    900

gtgtttttga agatgacctc cccttcttag aattcactgg atccattgtg tatagttacg    960

atgctagtga ttgctctttc ctgtcagaag atattagcat gagtctatca gatggggatg   1020

tggtgggatt tgacatggag tggccaccat tatacaatag agggaaactt ggcaaagttg   1080

cactaattca gttgtgtgtt tctgagagca aatgttactt gttccacgtt tcttccatgt   1140

cagtttttcc ccagggatta aaaatgttgc ttgaaaataa agcagttaaa aaggcaggtg   1200

taggaattga aggagatcag tggaaacttc tacgtgactt tgatatcaaa ttgaagaatt   1260

ttgtggagtt gacagatgtt gccaataaaa agctgaaatg tacagagacc tggagcctta   1320

acagtctggt taaacacctc ttaggtaaac agctcctgaa agacaagtct atccgctgta   1380

gcaattggag taaatttcct ctcactgagg accagaaact gtatgcagcc actgatgctt   1440

atgctggttt tattatttac cgaaatttag agattttgga tgatactgtg caaaggtttg   1500

ctataaataa agaggaagaa atcctactta gcgacatgaa caaacagttg acttcaatct   1560

ctgaggaagt gatggatctg gctaagcatc ttcctcatgc tttcagtaaa ttggaaaacc   1620

cacggagggt ttctatctta ctaaaggata tttcagaaaa tctatattca ctgaggagga   1680

tgataattgg gtctactaac attgagactg aactgaggcc cagcaataat ttaaacttat   1740

tatcctttga agattcaact actgggggag tacaacagaa acaaattaga gaacatgaag   1800

ttttaattca cgttgaagat gaaacatggg acccaacact tgatcattta gctaaacatg   1860

atggagaaga tgtacttgga aataaagtgg aacgaaaaga agatggattt gaagatggag   1920

tagaagacaa caaattgaaa gagaatatgg aaagagcttg tttgatgtcg ttagatatta   1980

cagaacatga actccaaatt ttggaacagc agtctcagga agaatatctt agtgatattg   2040

cttataaatc tactgagcat ttatctccca atgataatga aaacgatacg tcctatgtaa   2100

ttgagagtga tgaagattta gaaatggaga tgcttaagca tttatctccc aatgataatg   2160

aaaacgatac gtcctatgta attgagagtg atgaagattt agaaatggag atgcttaagt   2220

ctttagaaaa cctcaatagt ggcacggtag aaccaactca ttctaaatgc ttaaaaatgg   2280

aaagaaatct gggtcttcct actaaagaag aagaagaaga tgatgaaaat gaagctaatg   2340

aaggggaaga agatgatgat aaggactttt tgtggccagc acccaatgaa gagcaagtta   2400

cttgcctcaa gatgtacttt ggccattcca gttttaaacc agttcagtgg aaagtgattc   2460

attcagtatt agaagaaaga agagataatg ttgctgtcat ggcaactgga tatggaaaga   2520

gtttgtgctt ccagtatcca cctgtttatg taggcaagat tggccttgtt atctctcccc   2580

ttatttctct gatggaagac caagtgctac agcttaaaat gtccaacatc ccagcttgct   2640

tccttggatc agcacagtca gaaaatgttc taacagatat taaattaggt aaataccgga   2700

ttgtatacgt aactccagaa tactgttcag gtaacatggg cctgctccag caacttgagg   2760

ctgatattgg tatcacgctc attgctgtgg atgaggctca ctgtatttct gagtgggggc   2820

atgattttag ggattcattc aggaagttgg gctccctaaa gacagcactg ccaatggttc   2880

caatcgttgc acttactgct actgcaagtt cttcaatccg ggaagacatt gtacgttgct   2940

taaatctgag aaatcctcag atcacctgta ctggttttga tcgaccaaac ctgtatttag   3000

aagttaggcg aaaaacaggg aatatccttc aggatctgca gccatttctt gtcaaaacaa   3060

gttcccactg ggaatttgaa ggtccaacaa tcatctactg tccttctaga aaaatgacac   3120

aacaagttac aggtgaactt aggaaactga atctatcctg tggaacatac catgcgggca   3180

tgagttttag cacaaggaaa gacattcatc ataggtttgt aagagatgaa attcagtgtg   3240

tcatagctac catagctttt ggaatgggca ttaataaagc tgacattcgc caagtcattc   3300

attacggtgc tcctaaggac atggaatcat attatcagga gattggtaga gctggtcgtg   3360

atggacttca aagttcttgt cacgtcctct gggctcctgc agacattaac ttaaataggc   3420

accttcttac tgagatacgt aatgagaagt ttcgattata caaattaaag atgatggcaa   3480

agatggaaaa atatcttcat tctagcagat gtaggagaca aatcatcttg tctcattttg   3540

aggacaaaca agtacaaaaa gcctccttgg gaattatggg aactgaaaaa tgctgtgata   3600

attgcaggtc cagattggat cattgctatt ccatggatga ctcagaggat acatcctggg   3660

actttggtcc acaagcattt aagcttttgt ctgctgtgga catcttaggc gaaaaatttg   3720

gaattgggct tccaatttta tttctccgag gatctaattc tcagcgtctt gccgatcaat   3780

atcgcaggca cagtttattt ggcactggca aggatcaaac agagagttgg tggaaggctt   3840

tttcccgtca gctgatcact gagggattct tggtagaagt ttctcggtat aacaaattta   3900

tgaagatttg cgcccttacg aaaaagggta gaaattggct tcataaagct aatacagaat   3960

ctcagagcct catccttcaa gctaatgaag aattgtgtcc aaagaagttg cttctgccta   4020

gttcgaaaac tgtatcttcg ggcaccaaag agcattgtta taatcaagta ccagttgaat   4080

taagtacaga gaagaagtct aacttggaga agttatattc ttataaacca tgtgataaga   4140

tttcttctgg gagtaacatt tctaaaaaaa gtatcatggt acagtcacca gaaaaagctt   4200

acagttcctc acagcctgtt atttcggcac aagagcagga gactcagatt gtgttatatg   4260

gcaaattggt agaagctagg cagaaacatg ccaataaaat ggatgttccc ccagctattc   4320

tggcaacaaa caagatactg gtggatatgg ccaaaatgag accaactacg gttgaaaacg   4380

taaaaaggat tgatggtgtt tctgaaggca aagctgccat gttggcccct ctgttggaag   4440

tcatcaaaca tttctgccaa acaaatagtg ttcagacaga cctcttttca agtacaaaac   4500

ctcaagaaga acagaagacg agtctggtag caaaaaataa aatatgcaca ctttcacagt   4560

ctatggccat cacatactct ttattccaag aaaagaagat gcctttgaag agcatagctg   4620

agagcaggat tctgcctctc atgacaattg gcatgcactt atcccaagcg gtgaaagctg   4680

gctgccccct tgatttggag cgagcaggcc tgactccaga ggttcagaag attattgctg   4740

atgttatccg aaaccctccc gtcaactcag atatgagtaa aattagccta atcagaatgt   4800

tagttcctga aaacattgac acgtacctta tccacatggc aattgagatc cttaaacatg   4860

gtcctgacag cggacttcaa ccttcatgtg atgtcaacaa aaggagatgt tttcccggtt   4920

ctgaagagat ctgttcaagt tctaagagaa gcaaggaaga agtaggcatc aatactgaga   4980

cttcatctgc agagagaaag agacgattac ctgtgtggtt tgccaaagga agtgatacca   5040

gcaagaaatt aatggacaaa acgaaaaggg gaggtctttt tagttaagct ggcaattacc   5100

agaacaatta tgtttcttgc tgtattataa gaggatagct atattttatt tctgaagagt   5160

aaggagtagt attttggctt aaaaatcatt ctaattacaa agttcactgt ttattgaaga   5220

actggcatct taaatcagcc ttccgcaatt catgtagttt ctgggtcttc tgggagccta   5280

cgtgagtaca tcacctaaca gaatattaaa ttagacttcc tgtaagattg ctttaagaaa   5340

ctgttactgt cctgttttct aatctcttta ttaaaacagt gtatttggaa aatgttatgt   5400

gctctgattt gatatagata acagattagt agttacatgg taattatgtg atataaaata   5460

ttcatatatt atcaaaattc tgttttgtaa atgtaagaaa gcatagttat tttacaaatt   5520

gtttttactg tcttttgaag aagttcttaa atacgttgtt aaatggtatt agttgaccag   5580

ggcagtgaaa atgaaaccgc attttgggtg ccattaaata gggaaaaaac atgtaaaaaa   5640

tgtaaaatgg agaccaattg cactaggcaa gtgtatattt tgtattttat atacaatttc   5700

tattattttt caagtaataa aacaatgttt ttcatactga atatt                   5745


<210>  520
<211>  1432
<212>  PRT
<213>  Homo sapiens

<400>  520

Met Ser Glu Lys Lys Leu Glu Thr Thr Ala Gln Gln Arg Lys Cys Pro 
1               5                   10                  15


Glu Trp Met Asn Val Gln Asn Lys Arg Cys Ala Val Glu Glu Arg Lys 
            20                  25                  30


Ala Cys Val Arg Lys Ser Val Phe Glu Asp Asp Leu Pro Phe Leu Glu 
        35                  40                  45


Phe Thr Gly Ser Ile Val Tyr Ser Tyr Asp Ala Ser Asp Cys Ser Phe 
    50                  55                  60


Leu Ser Glu Asp Ile Ser Met Ser Leu Ser Asp Gly Asp Val Val Gly 
65                  70                  75                  80


Phe Asp Met Glu Trp Pro Pro Leu Tyr Asn Arg Gly Lys Leu Gly Lys 
                85                  90                  95


Val Ala Leu Ile Gln Leu Cys Val Ser Glu Ser Lys Cys Tyr Leu Phe 
            100                 105                 110


His Val Ser Ser Met Ser Val Phe Pro Gln Gly Leu Lys Met Leu Leu 
        115                 120                 125


Glu Asn Lys Ala Val Lys Lys Ala Gly Val Gly Ile Glu Gly Asp Gln 
    130                 135                 140


Trp Lys Leu Leu Arg Asp Phe Asp Ile Lys Leu Lys Asn Phe Val Glu 
145                 150                 155                 160


Leu Thr Asp Val Ala Asn Lys Lys Leu Lys Cys Thr Glu Thr Trp Ser 
                165                 170                 175


Leu Asn Ser Leu Val Lys His Leu Leu Gly Lys Gln Leu Leu Lys Asp 
            180                 185                 190


Lys Ser Ile Arg Cys Ser Asn Trp Ser Lys Phe Pro Leu Thr Glu Asp 
        195                 200                 205


Gln Lys Leu Tyr Ala Ala Thr Asp Ala Tyr Ala Gly Phe Ile Ile Tyr 
    210                 215                 220


Arg Asn Leu Glu Ile Leu Asp Asp Thr Val Gln Arg Phe Ala Ile Asn 
225                 230                 235                 240


Lys Glu Glu Glu Ile Leu Leu Ser Asp Met Asn Lys Gln Leu Thr Ser 
                245                 250                 255


Ile Ser Glu Glu Val Met Asp Leu Ala Lys His Leu Pro His Ala Phe 
            260                 265                 270


Ser Lys Leu Glu Asn Pro Arg Arg Val Ser Ile Leu Leu Lys Asp Ile 
        275                 280                 285


Ser Glu Asn Leu Tyr Ser Leu Arg Arg Met Ile Ile Gly Ser Thr Asn 
    290                 295                 300


Ile Glu Thr Glu Leu Arg Pro Ser Asn Asn Leu Asn Leu Leu Ser Phe 
305                 310                 315                 320


Glu Asp Ser Thr Thr Gly Gly Val Gln Gln Lys Gln Ile Arg Glu His 
                325                 330                 335


Glu Val Leu Ile His Val Glu Asp Glu Thr Trp Asp Pro Thr Leu Asp 
            340                 345                 350


His Leu Ala Lys His Asp Gly Glu Asp Val Leu Gly Asn Lys Val Glu 
        355                 360                 365


Arg Lys Glu Asp Gly Phe Glu Asp Gly Val Glu Asp Asn Lys Leu Lys 
    370                 375                 380


Glu Asn Met Glu Arg Ala Cys Leu Met Ser Leu Asp Ile Thr Glu His 
385                 390                 395                 400


Glu Leu Gln Ile Leu Glu Gln Gln Ser Gln Glu Glu Tyr Leu Ser Asp 
                405                 410                 415


Ile Ala Tyr Lys Ser Thr Glu His Leu Ser Pro Asn Asp Asn Glu Asn 
            420                 425                 430


Asp Thr Ser Tyr Val Ile Glu Ser Asp Glu Asp Leu Glu Met Glu Met 
        435                 440                 445


Leu Lys His Leu Ser Pro Asn Asp Asn Glu Asn Asp Thr Ser Tyr Val 
    450                 455                 460


Ile Glu Ser Asp Glu Asp Leu Glu Met Glu Met Leu Lys Ser Leu Glu 
465                 470                 475                 480


Asn Leu Asn Ser Gly Thr Val Glu Pro Thr His Ser Lys Cys Leu Lys 
                485                 490                 495


Met Glu Arg Asn Leu Gly Leu Pro Thr Lys Glu Glu Glu Glu Asp Asp 
            500                 505                 510


Glu Asn Glu Ala Asn Glu Gly Glu Glu Asp Asp Asp Lys Asp Phe Leu 
        515                 520                 525


Trp Pro Ala Pro Asn Glu Glu Gln Val Thr Cys Leu Lys Met Tyr Phe 
    530                 535                 540


Gly His Ser Ser Phe Lys Pro Val Gln Trp Lys Val Ile His Ser Val 
545                 550                 555                 560


Leu Glu Glu Arg Arg Asp Asn Val Ala Val Met Ala Thr Gly Tyr Gly 
                565                 570                 575


Lys Ser Leu Cys Phe Gln Tyr Pro Pro Val Tyr Val Gly Lys Ile Gly 
            580                 585                 590


Leu Val Ile Ser Pro Leu Ile Ser Leu Met Glu Asp Gln Val Leu Gln 
        595                 600                 605


Leu Lys Met Ser Asn Ile Pro Ala Cys Phe Leu Gly Ser Ala Gln Ser 
    610                 615                 620


Glu Asn Val Leu Thr Asp Ile Lys Leu Gly Lys Tyr Arg Ile Val Tyr 
625                 630                 635                 640


Val Thr Pro Glu Tyr Cys Ser Gly Asn Met Gly Leu Leu Gln Gln Leu 
                645                 650                 655


Glu Ala Asp Ile Gly Ile Thr Leu Ile Ala Val Asp Glu Ala His Cys 
            660                 665                 670


Ile Ser Glu Trp Gly His Asp Phe Arg Asp Ser Phe Arg Lys Leu Gly 
        675                 680                 685


Ser Leu Lys Thr Ala Leu Pro Met Val Pro Ile Val Ala Leu Thr Ala 
    690                 695                 700


Thr Ala Ser Ser Ser Ile Arg Glu Asp Ile Val Arg Cys Leu Asn Leu 
705                 710                 715                 720


Arg Asn Pro Gln Ile Thr Cys Thr Gly Phe Asp Arg Pro Asn Leu Tyr 
                725                 730                 735


Leu Glu Val Arg Arg Lys Thr Gly Asn Ile Leu Gln Asp Leu Gln Pro 
            740                 745                 750


Phe Leu Val Lys Thr Ser Ser His Trp Glu Phe Glu Gly Pro Thr Ile 
        755                 760                 765


Ile Tyr Cys Pro Ser Arg Lys Met Thr Gln Gln Val Thr Gly Glu Leu 
    770                 775                 780


Arg Lys Leu Asn Leu Ser Cys Gly Thr Tyr His Ala Gly Met Ser Phe 
785                 790                 795                 800


Ser Thr Arg Lys Asp Ile His His Arg Phe Val Arg Asp Glu Ile Gln 
                805                 810                 815


Cys Val Ile Ala Thr Ile Ala Phe Gly Met Gly Ile Asn Lys Ala Asp 
            820                 825                 830


Ile Arg Gln Val Ile His Tyr Gly Ala Pro Lys Asp Met Glu Ser Tyr 
        835                 840                 845


Tyr Gln Glu Ile Gly Arg Ala Gly Arg Asp Gly Leu Gln Ser Ser Cys 
    850                 855                 860


His Val Leu Trp Ala Pro Ala Asp Ile Asn Leu Asn Arg His Leu Leu 
865                 870                 875                 880


Thr Glu Ile Arg Asn Glu Lys Phe Arg Leu Tyr Lys Leu Lys Met Met 
                885                 890                 895


Ala Lys Met Glu Lys Tyr Leu His Ser Ser Arg Cys Arg Arg Gln Ile 
            900                 905                 910


Ile Leu Ser His Phe Glu Asp Lys Gln Val Gln Lys Ala Ser Leu Gly 
        915                 920                 925


Ile Met Gly Thr Glu Lys Cys Cys Asp Asn Cys Arg Ser Arg Leu Asp 
    930                 935                 940


His Cys Tyr Ser Met Asp Asp Ser Glu Asp Thr Ser Trp Asp Phe Gly 
945                 950                 955                 960


Pro Gln Ala Phe Lys Leu Leu Ser Ala Val Asp Ile Leu Gly Glu Lys 
                965                 970                 975


Phe Gly Ile Gly Leu Pro Ile Leu Phe Leu Arg Gly Ser Asn Ser Gln 
            980                 985                 990


Arg Leu Ala Asp Gln Tyr Arg Arg His Ser Leu Phe Gly Thr Gly Lys 
        995                 1000                1005


Asp Gln Thr Glu Ser Trp Trp Lys Ala Phe Ser Arg Gln Leu Ile Thr 
    1010                1015                1020


Glu Gly Phe Leu Val Glu Val Ser Arg Tyr Asn Lys Phe Met Lys Ile 
1025                1030                1035                1040


Cys Ala Leu Thr Lys Lys Gly Arg Asn Trp Leu His Lys Ala Asn Thr 
                1045                1050                1055


Glu Ser Gln Ser Leu Ile Leu Gln Ala Asn Glu Glu Leu Cys Pro Lys 
            1060                1065                1070


Lys Leu Leu Leu Pro Ser Ser Lys Thr Val Ser Ser Gly Thr Lys Glu 
        1075                1080                1085


His Cys Tyr Asn Gln Val Pro Val Glu Leu Ser Thr Glu Lys Lys Ser 
    1090                1095                1100


Asn Leu Glu Lys Leu Tyr Ser Tyr Lys Pro Cys Asp Lys Ile Ser Ser 
1105                1110                1115                1120


Gly Ser Asn Ile Ser Lys Lys Ser Ile Met Val Gln Ser Pro Glu Lys 
                1125                1130                1135


Ala Tyr Ser Ser Ser Gln Pro Val Ile Ser Ala Gln Glu Gln Glu Thr 
            1140                1145                1150


Gln Ile Val Leu Tyr Gly Lys Leu Val Glu Ala Arg Gln Lys His Ala 
        1155                1160                1165


Asn Lys Met Asp Val Pro Pro Ala Ile Leu Ala Thr Asn Lys Ile Leu 
    1170                1175                1180


Val Asp Met Ala Lys Met Arg Pro Thr Thr Val Glu Asn Val Lys Arg 
1185                1190                1195                1200


Ile Asp Gly Val Ser Glu Gly Lys Ala Ala Met Leu Ala Pro Leu Leu 
                1205                1210                1215


Glu Val Ile Lys His Phe Cys Gln Thr Asn Ser Val Gln Thr Asp Leu 
            1220                1225                1230


Phe Ser Ser Thr Lys Pro Gln Glu Glu Gln Lys Thr Ser Leu Val Ala 
        1235                1240                1245


Lys Asn Lys Ile Cys Thr Leu Ser Gln Ser Met Ala Ile Thr Tyr Ser 
    1250                1255                1260


Leu Phe Gln Glu Lys Lys Met Pro Leu Lys Ser Ile Ala Glu Ser Arg 
1265                1270                1275                1280


Ile Leu Pro Leu Met Thr Ile Gly Met His Leu Ser Gln Ala Val Lys 
                1285                1290                1295


Ala Gly Cys Pro Leu Asp Leu Glu Arg Ala Gly Leu Thr Pro Glu Val 
            1300                1305                1310


Gln Lys Ile Ile Ala Asp Val Ile Arg Asn Pro Pro Val Asn Ser Asp 
        1315                1320                1325


Met Ser Lys Ile Ser Leu Ile Arg Met Leu Val Pro Glu Asn Ile Asp 
    1330                1335                1340


Thr Tyr Leu Ile His Met Ala Ile Glu Ile Leu Lys His Gly Pro Asp 
1345                1350                1355                1360


Ser Gly Leu Gln Pro Ser Cys Asp Val Asn Lys Arg Arg Cys Phe Pro 
                1365                1370                1375


Gly Ser Glu Glu Ile Cys Ser Ser Ser Lys Arg Ser Lys Glu Glu Val 
            1380                1385                1390


Gly Ile Asn Thr Glu Thr Ser Ser Ala Glu Arg Lys Arg Arg Leu Pro 
        1395                1400                1405


Val Trp Phe Ala Lys Gly Ser Asp Thr Ser Lys Lys Leu Met Asp Lys 
    1410                1415                1420


Thr Lys Arg Gly Gly Leu Phe Ser 
1425                1430


<210>  521
<211>  3549
<212>  DNA
<213>  Homo sapiens

<400>  521
gtcttcccgg cgcccaggct tgggctcata gggagaaagg aagctgcgct gcattctgcg     60

ggacgaaccc tgctccgcgc gagaattttt ttgattcctt cttatttgga gaaatctcca    120

gctgctctga tgatagccta agaagactgc atgctgcttc ctctcgatgc caagccagac    180

cctctcacaa cctcggatct cagtccttca tggagacctg gtcccagcag gaatggcagt    240

gcaggaaatt ggcgcccaga tggttcttcc atgtgaagtt gtctcgggct ctgggctgac    300

gagagaacac ctggtaacca ggttagccct ctgtcagtca cccagggcag ggcagcatgg    360

tgcggattca gaggaggaag cttttggcat cttgcctgtg cgtcacagcc accgtctttc    420

tgcttgtcac actccaggtc atggttgagc tggggaagtt tgaaaggaag gagtttaaaa    480

gttccagttt gcaagatgga catacaaaaa tggaggaagc acctacgcat cttaattcat    540

ttcttaagaa agaaggattg accttcaaca ggaaaagaaa atgggaattg gacagctacc    600

ccattatgct ctggtggtcc ccgctgacgg gggagactgg gaggttaggc caatgtggag    660

cagatgcttg tttcttcacc atcaaccgga cctacctcca tcatcacatg accaaagcat    720

tcctcttcta tggtactgac tttaacatag atagcttacc tctgcctcgg aaagcccatc    780

atgactgggc tgtttttcat gaagagtccc cgaaaaacaa ttataagctc tttcataaac    840

cagtgatcac cttgttcaac tacactgcca cgttcagcag gcattcccac ttgccactaa    900

ctacccaata cttggagagc attgaagtcc tgaagtcact ccgataccta gttcctttgc    960

agtccaaaaa caagcttaga aaaagacttg ctccgctggt gtatgtacag tcagactgtg   1020

acccaccatc agacagggac agctatgttc gcgagctgat gacttacatc gaggtcgatt   1080

cctatggtga atgtttacga aacaaagacc tccctcagca gctgaaaaat ccagcctcta   1140

tggatgccga tggcttttat aggatcattg cacagtataa gtttatccta gcttttgaga   1200

atgcagtttg tgatgactac atcactgaga agttctggag gccactgaaa ctgggggtag   1260

tccctgtata ttacggatcc cccagcatca cagactggct tccaagtaac aaaagtgcta   1320

ttcttgtatc agaattttct caccccaggg aactggcaag ttacatcaga cgactggatt   1380

ctgatgacag attgtatgag gcctatgtag aatggaagct gaagggtgag atctctaacc   1440

agcgacttct gacagctctc agggaacgga aatggggagt gcaagacgtc aaccaggaca   1500

attacatcga tgcatttgag tgtatggtgt gcaccaaggt gtgggctaat atcaggcttc   1560

aggaaaaggg cttaccaccc aaaagatggg aggcagaaga tacccacctg agttgcccag   1620

agcccacagt gtttgctttc tcaccactcc ggactccacc tttgagctct ttgcgagaga   1680

tgtggatttc cagctttgaa caatccaaga aagaagccca ggcactaagg tggctggttg   1740

ataggaatca aaacttttca tctcaagagt tttggggcct agtattcaag gactgatttc   1800

aaaaatgatc agaatgaaac agactagagc cttcttgagg tttattttct aggttgcctt   1860

aatatttgaa cataatagct attctgttga ctatccatca ggataataat tagttgctgc   1920

agtactcata atgagccctt tcaaggaata gatgtaaatt acccttaggg gtagccacta   1980

tattttttat actaaaaaag gaaatatttc ttatggacac tggttatctt ccatgtccgt   2040

gtctgtggac ccacatactt actgcctttt gtggaaattc acctagagtg agtactttcc   2100

ttgtgcaatg gagggagacg atctagctat agattcttga tactcacctc actctcaaca   2160

gcttattggt atttggcaaa cctggtatcc tgcagccgag catgaacatg aaatacatta   2220

gaacttggca atgagagatc ccatctgttg gtttccaggg atgtaagtga gtaataaaag   2280

ctgtttcaag tttatccact atccactctt caagtgaaaa gaacttatgt gtgtctacct   2340

tcttctccat accctgagcc acctctctca ctttctttag ttgtgccttg ccctatcgcc   2400

tcccattttc ccttcaaagt agaatgtctt gtaaagacac agtaactcct gtgtgttttg   2460

attagtgaga tgttaccact taccccttct gctgcgcaga ataatattaa gaattgctat   2520

gcttatgatt caggctggac agcctggaca ttttgagcag cgcgagagta gaagtgaata   2580

cccccaggaa ctccaattgt gctgaagctg atttgtctgt tcgtaggatg atgtgcagcc   2640

tgtcacagtg gcagccacag gcattcagtt tgtgggcatt tcctgtcatt tcggatcctg   2700

ctatagggaa ggttcagctc tcctgtctgg ggcatctact ggagcacctc agaagacaag   2760

gaggaaaaca ctggctcatg ttttctttcc atgtgaggga ggggaggttt ctagatgata   2820

ctaaaagcct gttgccactg ttgtgtcatg atttccattc ttcatcatgg aaagccacaa   2880

gcctcagaag gcagccagag gacaggaaga gtctgtgatg ctcatgtctg tgtcatggca   2940

tgagggggaa ttgacgagtg cttgcttagc atcagctctc attgtattga aggctgtgcc   3000

cttggtgtgc ttagcagtga gcagcgtctt cattaggtag ctctggctgg gctttgtcag   3060

ccagcgtgtg agaaaggaga accaaaacca atacctcctt atagaagcca gaaggatcac   3120

attggatgag agaaggtgtc tataactggg ttcttcccaa tcccagctct ttcattaact   3180

aaatatgatc ttggacatat ctcttaacct ccatcggcct tagtttttgc atccaaaaag   3240

aagtgattgg gctggtcttg gaaggttttt ttcttttttt tcccctgtgt aacattcttc   3300

attgttcatc aacatttaag aaatttaatt ttgtagatgt ttttactaaa gagggtaaca   3360

aactattttg gaactgctgt atgttattca agggaagcac gctgtttgga ggaaggagca   3420

tacttaatgg gtagtattga ggatgaaagg gaatttctct ctctgccatt ttatttgata   3480

atattaaaga aataaagact ggaaaggggg attccttgtt aaaggtcaga ttttaaattg   3540

catataaaa                                                           3549


<210>  522
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  522

Met Val Arg Ile Gln Arg Arg Lys Leu Leu Ala Ser Cys Leu Cys Val 
1               5                   10                  15


Thr Ala Thr Val Phe Leu Leu Val Thr Leu Gln Val Met Val Glu Leu 
            20                  25                  30


Gly Lys Phe Glu Arg Lys Glu Phe Lys Ser Ser Ser Leu Gln Asp Gly 
        35                  40                  45


His Thr Lys Met Glu Glu Ala Pro Thr His Leu Asn Ser Phe Leu Lys 
    50                  55                  60


Lys Glu Gly Leu Thr Phe Asn Arg Lys Arg Lys Trp Glu Leu Asp Ser 
65                  70                  75                  80


Tyr Pro Ile Met Leu Trp Trp Ser Pro Leu Thr Gly Glu Thr Gly Arg 
                85                  90                  95


Leu Gly Gln Cys Gly Ala Asp Ala Cys Phe Phe Thr Ile Asn Arg Thr 
            100                 105                 110


Tyr Leu His His His Met Thr Lys Ala Phe Leu Phe Tyr Gly Thr Asp 
        115                 120                 125


Phe Asn Ile Asp Ser Leu Pro Leu Pro Arg Lys Ala His His Asp Trp 
    130                 135                 140


Ala Val Phe His Glu Glu Ser Pro Lys Asn Asn Tyr Lys Leu Phe His 
145                 150                 155                 160


Lys Pro Val Ile Thr Leu Phe Asn Tyr Thr Ala Thr Phe Ser Arg His 
                165                 170                 175


Ser His Leu Pro Leu Thr Thr Gln Tyr Leu Glu Ser Ile Glu Val Leu 
            180                 185                 190


Lys Ser Leu Arg Tyr Leu Val Pro Leu Gln Ser Lys Asn Lys Leu Arg 
        195                 200                 205


Lys Arg Leu Ala Pro Leu Val Tyr Val Gln Ser Asp Cys Asp Pro Pro 
    210                 215                 220


Ser Asp Arg Asp Ser Tyr Val Arg Glu Leu Met Thr Tyr Ile Glu Val 
225                 230                 235                 240


Asp Ser Tyr Gly Glu Cys Leu Arg Asn Lys Asp Leu Pro Gln Gln Leu 
                245                 250                 255


Lys Asn Pro Ala Ser Met Asp Ala Asp Gly Phe Tyr Arg Ile Ile Ala 
            260                 265                 270


Gln Tyr Lys Phe Ile Leu Ala Phe Glu Asn Ala Val Cys Asp Asp Tyr 
        275                 280                 285


Ile Thr Glu Lys Phe Trp Arg Pro Leu Lys Leu Gly Val Val Pro Val 
    290                 295                 300


Tyr Tyr Gly Ser Pro Ser Ile Thr Asp Trp Leu Pro Ser Asn Lys Ser 
305                 310                 315                 320


Ala Ile Leu Val Ser Glu Phe Ser His Pro Arg Glu Leu Ala Ser Tyr 
                325                 330                 335


Ile Arg Arg Leu Asp Ser Asp Asp Arg Leu Tyr Glu Ala Tyr Val Glu 
            340                 345                 350


Trp Lys Leu Lys Gly Glu Ile Ser Asn Gln Arg Leu Leu Thr Ala Leu 
        355                 360                 365


Arg Glu Arg Lys Trp Gly Val Gln Asp Val Asn Gln Asp Asn Tyr Ile 
    370                 375                 380


Asp Ala Phe Glu Cys Met Val Cys Thr Lys Val Trp Ala Asn Ile Arg 
385                 390                 395                 400


Leu Gln Glu Lys Gly Leu Pro Pro Lys Arg Trp Glu Ala Glu Asp Thr 
                405                 410                 415


His Leu Ser Cys Pro Glu Pro Thr Val Phe Ala Phe Ser Pro Leu Arg 
            420                 425                 430


Thr Pro Pro Leu Ser Ser Leu Arg Glu Met Trp Ile Ser Ser Phe Glu 
        435                 440                 445


Gln Ser Lys Lys Glu Ala Gln Ala Leu Arg Trp Leu Val Asp Arg Asn 
    450                 455                 460


Gln Asn Phe Ser Ser Gln Glu Phe Trp Gly Leu Val Phe Lys Asp 
465                 470                 475


<210>  523
<211>  2691
<212>  DNA
<213>  Homo sapiens

<400>  523
agaagcctga ggagccggag agggtgctgg ctgccgcgcg gccgagtgtg ttttatggac     60

catgtgctgc tatgtatgcc tgaagaagta cttgaaatgc aaatttgggg agactttgcc    120

atataaatgc ttggctggat taagcgccta attaggatgg tttttcaaca agttggagta    180

agcatgcaat cggtactttg gtctaggaag ccatatggtt cgtctcgaag tatcgtaagg    240

aaaattggta ctaatttgtc tctgattcag tgtccaagag ttcagtttca gattaacagc    300

catgcaacag aatggagtcc cagccaccca ggagaggatg cagtggcgtc ttttgctgat    360

gttggatggg tagccaaaga agaaggagag tgttcagcaa gactaaggac agaggtcaga    420

tcaaggccac cccttcagga tgaccttctt ttctttgaga aggccccaag cagacagatt    480

tccttaccag acttgtctca agaagagcct cagctgaaga ccccagcgcg ggcaaatgag    540

gaagcactgc agaagatttg cgctctcgaa aatgaacttg ctgctctcag agctcagatt    600

gccaaaattg tgacccagca ggagcagcaa aatctcactg caggtgactt agattctacc    660

acatttggta ccataccacc acaccctcca cctcccccac cgcccctgcc tccccctgca    720

ctggggctcc accaaagtac atctgctgtt gatctgatta aagaacgaag agagaaaaga    780

gccaatgctg gaaagacttt ggttaagaac aatccaaaga aacctgaaat gccaaatatg    840

ctagagatcc ttaaagagat gaacagtgta aaacttcggt cagtgaagag gtcagagcaa    900

gatgtgaagc ccaagccagt ggatgctact gaccctgctg ccctcatagc agaggctctg    960

aaaaagaaat ttgcttatcg gtatcgaagt gatagccaag atgaagttga aaaaggaatt   1020

ccaaagtctg aatcagaggc cacctcagag agagtgttgt ttgggccaca catgttgaag   1080

ccaacaggaa aaatgaaggc tttaattgaa aatgtatcag actcctaata gacaatgagc   1140

tgcgaaaaga ctcctggttc ccctgttgat ttgtgagggc caagtttgct agtagaaatc   1200

gacactgttt agtaaatacc tctttagtat tcagtggtct tcttttcagg ctaattagtg   1260

gattaagcaa taatgaaagc actaagtttg gttttgcttt tgtgagatgg tcagctttgg   1320

tgctctccac aacatgtgtg ttctgacatg tttctaatat gtggccaggg cgttcagatt   1380

tccagttttg aaaacaattg tatagatttc acaacacaaa aaggacattt gtggatgtta   1440

ctgcacattt taaattctta acactaattt atctgtataa gtgttttata tgcatatttt   1500

tggacataaa cagtttatgt aaaattagta atgaatgatg gcaacgaggg cactgttatc   1560

ttcgtttgtt ttcaatgatc atttagcatt caatgatgga acagctggta taacataagt   1620

tgttggcatg aaatatttga gattggaaac ttcttgcctt gaacagaact tatatcttag   1680

attctctctc acattttctt ggagctgggg tttgaatagg aaccagatga tgttcactgc   1740

tgaaattcca taatgcttcc cattgaaggg aagttgagaa ccaggaaagc tgctttcacg   1800

tcattgccat ccagtactga cagggaagaa agatgtagtt ttccagtagt gatgaatcaa   1860

attattgaat taaatttctt cttaagaagt aaaaactcag aatgtaccat cttgtttcct   1920

ttcagtttat taaatggcat cataaagatg actttgctaa gttaatagag ttaaaaattt   1980

ttttaatata agccaaaata ttaactttaa tgaaacattg acttggcaaa tgaatttcct   2040

ataaattatc attggtcaga atgctgtttt gtttaataat attacgcaac ataaaccata   2100

ggtgttatta gaagtggaga actgcctttt tcatctgggg cttttaagga cttgctataa   2160

atgattattt tttaaatgct ttataaatct tcatggtttt tctatttctg atacactcag   2220

ctatagttaa taccagagta tcctaccagg agtaatattt ggaatattta aatctagtaa   2280

aagaagaaag ttgtacttcc tggctgggag tattaggaga tgggagtaga gattcacttt   2340

taagttcttg aaaatatatg cattctccta aatattaaca aaaatgattt ggggaaatga   2400

catggcttga ttgttctgtt taaatttgta ctgtggctta tgttacacat gttcatgttc   2460

acctctcatt cacctgtttt atatggttta aaattctctt taacaaaatt cagaaaattc   2520

acctgaaacg tattttgacc taaaagaaac atatttttgt atcagtattg aattttggac   2580

agtgccccca tataaggaag ttactgtttt aaaataaagc aaactaactg ttttaaaaaa   2640

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaccaaaa aaaaaaaaaa a            2691


<210>  524
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  524

Met Leu Gly Trp Ile Lys Arg Leu Ile Arg Met Val Phe Gln Gln Val 
1               5                   10                  15


Gly Val Ser Met Gln Ser Val Leu Trp Ser Arg Lys Pro Tyr Gly Ser 
            20                  25                  30


Ser Arg Ser Ile Val Arg Lys Ile Gly Thr Asn Leu Ser Leu Ile Gln 
        35                  40                  45


Cys Pro Arg Val Gln Phe Gln Ile Asn Ser His Ala Thr Glu Trp Ser 
    50                  55                  60


Pro Ser His Pro Gly Glu Asp Ala Val Ala Ser Phe Ala Asp Val Gly 
65                  70                  75                  80


Trp Val Ala Lys Glu Glu Gly Glu Cys Ser Ala Arg Leu Arg Thr Glu 
                85                  90                  95


Val Arg Ser Arg Pro Pro Leu Gln Asp Asp Leu Leu Phe Phe Glu Lys 
            100                 105                 110


Ala Pro Ser Arg Gln Ile Ser Leu Pro Asp Leu Ser Gln Glu Glu Pro 
        115                 120                 125


Gln Leu Lys Thr Pro Ala Arg Ala Asn Glu Glu Ala Leu Gln Lys Ile 
    130                 135                 140


Cys Ala Leu Glu Asn Glu Leu Ala Ala Leu Arg Ala Gln Ile Ala Lys 
145                 150                 155                 160


Ile Val Thr Gln Gln Glu Gln Gln Asn Leu Thr Ala Gly Asp Leu Asp 
                165                 170                 175


Ser Thr Thr Phe Gly Thr Ile Pro Pro His Pro Pro Pro Pro Pro Pro 
            180                 185                 190


Pro Leu Pro Pro Pro Ala Leu Gly Leu His Gln Ser Thr Ser Ala Val 
        195                 200                 205


Asp Leu Ile Lys Glu Arg Arg Glu Lys Arg Ala Asn Ala Gly Lys Thr 
    210                 215                 220


Leu Val Lys Asn Asn Pro Lys Lys Pro Glu Met Pro Asn Met Leu Glu 
225                 230                 235                 240


Ile Leu Lys Glu Met Asn Ser Val Lys Leu Arg Ser Val Lys Arg Ser 
                245                 250                 255


Glu Gln Asp Val Lys Pro Lys Pro Val Asp Ala Thr Asp Pro Ala Ala 
            260                 265                 270


Leu Ile Ala Glu Ala Leu Lys Lys Lys Phe Ala Tyr Arg Tyr Arg Ser 
        275                 280                 285


Asp Ser Gln Asp Glu Val Glu Lys Gly Ile Pro Lys Ser Glu Ser Glu 
    290                 295                 300


Ala Thr Ser Glu Arg Val Leu Phe Gly Pro His Met Leu Lys Pro Thr 
305                 310                 315                 320


Gly Lys Met Lys Ala Leu Ile Glu Asn Val Ser Asp Ser 
                325                 330


<210>  525
<211>  1739
<212>  DNA
<213>  Homo sapiens

<400>  525
ggggatcact gttggaaggc agctgcttga ggtccaaggc agtcagtgtc ccctctcttt     60

tgcctcggga cagctggtat ttatcagact cctaagaagt tttccttgct ccctagtaga    120

agagagagat tatgcagcgg gcttttgatt gatccaatgg gaattacatt gatctggtgt    180

ctggccttgg ttcttatcaa gtggatcacc tctaagaggc gtggagctat ttcctatgac    240

agttctgatc agactgcatt atacattcgt atgctaggag atgtacgtgt aaggagccga    300

gcaggatttg aatcagaaag aagaggttct cacccatata ttgattttcg tattttccac    360

tctcaatctg aaattgaagt gtctgtctct gcaaggaata tcagaaggct actaagtttc    420

cagcgatatc ttagatcttc acgctttttt cgtggtactg cggtttcaaa ttccctaaac    480

attttagatg atgattataa tggacaagcc aagtgtatgc tggaaaaagt tggaaattgg    540

aattttgata tctttctatt tgatagacta acaaatggaa atagtctagt aagcttaacc    600

tttcatttat ttagtcttca tggattaatt gagtacttcc atttagatat gatgaaactt    660

cgtagatttt tagttatgat tcaagaagat taccacagtc aaaatcctta ccataacgca    720

gtccacgctg cggatgttac tcaggccatg cactgttact taaaggaacc taagcttgcc    780

aattctgtaa ctccttggga tatcttgctg agcttaattg cagctgccac tcatgatctg    840

gatcatccag gtgttaatca acctttcctt attaaaacta accattactt ggcaacttta    900

tacaagaata cctcagtact ggaaaatcac cactggagat ctgcagtggg cttattgaga    960

gaatcaggct tattctcaca tctgccatta gaaagcaggc aacaaatgga gacacagata   1020

ggtgctctga tactagccac agacatcagt cgccagaatg agtatctgtc tttgtttagg   1080

tcccatttgg atagaggtga tttatgccta gaagacacca gacacagaca tttggtttta   1140

cagatggctt tgaaatgtgc tgatatttgt aacccatgtc ggacgtggga attaagcaag   1200

cagtggagtg aaaaagtaac ggaggaattc ttccatcaag gagatataga aaaaaaatat   1260

catttgggtg tgagtccact ttgcgatcgt cacactgaat ctattgccaa catccagatt   1320

ggttttatga cttacctagt ggagccttta tttacagaat gggccaggtt ttccaataca   1380

aggctatccc agacaatgct tggacacgtg gggctgaata aagccagctg gaagggactg   1440

cagagagaac agtcgagcag tgaggacact gatgctgcat ttgagttgaa ctcacagtta   1500

ttacctcagg aaaatcggtt atcataaccc ccagaaccag tgggacaaac tgcctcctgg   1560

aggtttttag aaatgtgaaa tggggtcttg aggtgagaga acttaactct tgactgccaa   1620

ggtttccaag tgagtgatgc cagccagcat tatttatttc caagatttcc tctgttggat   1680

catttgaacc cacttgttaa ttgcaagacc cgaacataca gcaatatgaa tttggcttt    1739


<210>  526
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  526

Met Gly Ile Thr Leu Ile Trp Cys Leu Ala Leu Val Leu Ile Lys Trp 
1               5                   10                  15


Ile Thr Ser Lys Arg Arg Gly Ala Ile Ser Tyr Asp Ser Ser Asp Gln 
            20                  25                  30


Thr Ala Leu Tyr Ile Arg Met Leu Gly Asp Val Arg Val Arg Ser Arg 
        35                  40                  45


Ala Gly Phe Glu Ser Glu Arg Arg Gly Ser His Pro Tyr Ile Asp Phe 
    50                  55                  60


Arg Ile Phe His Ser Gln Ser Glu Ile Glu Val Ser Val Ser Ala Arg 
65                  70                  75                  80


Asn Ile Arg Arg Leu Leu Ser Phe Gln Arg Tyr Leu Arg Ser Ser Arg 
                85                  90                  95


Phe Phe Arg Gly Thr Ala Val Ser Asn Ser Leu Asn Ile Leu Asp Asp 
            100                 105                 110


Asp Tyr Asn Gly Gln Ala Lys Cys Met Leu Glu Lys Val Gly Asn Trp 
        115                 120                 125


Asn Phe Asp Ile Phe Leu Phe Asp Arg Leu Thr Asn Gly Asn Ser Leu 
    130                 135                 140


Val Ser Leu Thr Phe His Leu Phe Ser Leu His Gly Leu Ile Glu Tyr 
145                 150                 155                 160


Phe His Leu Asp Met Met Lys Leu Arg Arg Phe Leu Val Met Ile Gln 
                165                 170                 175


Glu Asp Tyr His Ser Gln Asn Pro Tyr His Asn Ala Val His Ala Ala 
            180                 185                 190


Asp Val Thr Gln Ala Met His Cys Tyr Leu Lys Glu Pro Lys Leu Ala 
        195                 200                 205


Asn Ser Val Thr Pro Trp Asp Ile Leu Leu Ser Leu Ile Ala Ala Ala 
    210                 215                 220


Thr His Asp Leu Asp His Pro Gly Val Asn Gln Pro Phe Leu Ile Lys 
225                 230                 235                 240


Thr Asn His Tyr Leu Ala Thr Leu Tyr Lys Asn Thr Ser Val Leu Glu 
                245                 250                 255


Asn His His Trp Arg Ser Ala Val Gly Leu Leu Arg Glu Ser Gly Leu 
            260                 265                 270


Phe Ser His Leu Pro Leu Glu Ser Arg Gln Gln Met Glu Thr Gln Ile 
        275                 280                 285


Gly Ala Leu Ile Leu Ala Thr Asp Ile Ser Arg Gln Asn Glu Tyr Leu 
    290                 295                 300


Ser Leu Phe Arg Ser His Leu Asp Arg Gly Asp Leu Cys Leu Glu Asp 
305                 310                 315                 320


Thr Arg His Arg His Leu Val Leu Gln Met Ala Leu Lys Cys Ala Asp 
                325                 330                 335


Ile Cys Asn Pro Cys Arg Thr Trp Glu Leu Ser Lys Gln Trp Ser Glu 
            340                 345                 350


Lys Val Thr Glu Glu Phe Phe His Gln Gly Asp Ile Glu Lys Lys Tyr 
        355                 360                 365


His Leu Gly Val Ser Pro Leu Cys Asp Arg His Thr Glu Ser Ile Ala 
    370                 375                 380


Asn Ile Gln Ile Gly Phe Met Thr Tyr Leu Val Glu Pro Leu Phe Thr 
385                 390                 395                 400


Glu Trp Ala Arg Phe Ser Asn Thr Arg Leu Ser Gln Thr Met Leu Gly 
                405                 410                 415


His Val Gly Leu Asn Lys Ala Ser Trp Lys Gly Leu Gln Arg Glu Gln 
            420                 425                 430


Ser Ser Ser Glu Asp Thr Asp Ala Ala Phe Glu Leu Asn Ser Gln Leu 
        435                 440                 445


Leu Pro Gln Glu Asn Arg Leu Ser 
    450                 455


<210>  527
<211>  2990
<212>  DNA
<213>  Homo sapiens

<400>  527
atggaagtgt gttaccagct gccggtactg cccctggaca ggccggtccc ccagcacgtc     60

ctcagccgcc gaggagccat cagcttcagc tccagctccg ctctcttcgg ctgccccaat    120

ccccggcagc tctctcagag gcgtggagct atttcctatg acagttctga tcagactgca    180

ttatacattc gtatgctagg agatgtacgt gtaaggagcc gagcaggatt tgaatcagaa    240

agaagaggtt ctcacccata tattgatttt cgtattttcc actctcaatc tgaaattgaa    300

gtgtctgtct ctgcaaggaa tatcagaagg ctactaagtt tccagcgata tcttagatct    360

tcacgctttt ttcgtggtac tgcggtttca aattccctaa acattttaga tgatgattat    420

aatggacaag ccaagtgtat gctggaaaaa gttggaaatt ggaattttga tatctttcta    480

tttgatagac taacaaatgg aaatagtcta gtaagcttaa cctttcattt atttagtctt    540

catggattaa ttgagtactt ccatttagat atgatgaaac ttcgtagatt tttagttatg    600

attcaagaag attaccacag tcaaaatcct taccataacg cagtccacgc tgcggatgtt    660

actcaggcca tgcactgtta cttaaaggaa cctaagcttg ccaattctgt aactccttgg    720

gatatcttgc tgagcttaat tgcagctgcc actcatgatc tggatcatcc aggtgttaat    780

caacctttcc ttattaaaac taaccattac ttggcaactt tatacaagaa tacctcagta    840

ctggaaaatc accactggag atctgcagtg ggcttattga gagaatcagg cttattctca    900

catctgccat tagaaagcag gcaacaaatg gagacacaga taggtgctct gatactagcc    960

acagacatca gtcgccagaa tgagtatctg tctttgttta ggtcccattt ggatagaggt   1020

gatttatgcc tagaagacac cagacacaga catttggttt tacagatggc tttgaaatgt   1080

gctgatattt gtaacccatg tcggacgtgg gaattaagca agcagtggag tgaaaaagta   1140

acggaggaat tcttccatca aggagatata gaaaaaaaat atcatttggg tgtgagtcca   1200

ctttgcgatc gtcacactga atctattgcc aacatccaga ttggtaacta tacatattta   1260

gatatagctg gttagaaaaa tgccactgtt tttatcaaga agggaaatat atttgaaata   1320

taaaatatta aaattatgct catttctatt tttaaaaata atttaagaaa ttttaccctt   1380

gttttccctt gttatggctc ttctaattct catttaattt taggatgtaa aaagtatatt   1440

tttgcagaac aggcagcagc aataacttgt ttctgttctt atgtaaataa gaatccatta   1500

ttcgctcatg tggaagcttc ttttgcatca tttgggactg ccatttaaaa aaggataggt   1560

aaacaaagaa atgacaaaaa taaaataaat aaaataaaaa tggataggtg gtgacccact   1620

gagcctgatc ataatacgaa gaccagcttc tgccactgcc tttccagact cttaccactg   1680

cctgttgatt aaatctaact cttcaacatc ctagacaggc ccttataatc ttgcttcaaa   1740

tgctgtgcag ccatcttgcc tcaacttccc tctcatttgc ctacagcatc tcgggacgct   1800

tctgtgtttc ccaagtatac gctgttcttt cgctctttgt gcttcgccag tgctttccat   1860

gtgcctcgta gagttatttt tcttgaagag gcagctcaaa tgtcaccttc tccagaagct   1920

gctctccact tgctttaggc agagtcagtc acttttcttc tagattccaa agtgcctgat   1980

ccacttggtt gtggattcct ggagcctagc accacaccag aagcacgagg cccttgagaa   2040

ctgtgtgttg agtgaactaa taactgtatt atagaaagca taatgaaaat gtcctgtgac   2100

tgaagtatgt gtagcttgtt gcaggagtca caggaaagtt gactaggatt gagtgtgttg   2160

ggctttgggt ataaaggagg gggattctac gggggcagta gctcaacaag gaatagaggg   2220

aggagtgtaa ttttggtagc tggtgttgaa tagggccttt gagaatcaga ctgaacacag   2280

tgaaatatgt gcccaaagtt cagaaagatg aagtttccag aaactaagaa ggtagcacaa   2340

tatgtggcat catactcaga aaggaagacc atgccatggg gccagaaatt cagaaacgta   2400

attcttacat tgtgattgca atggatactc atgaaagaaa gtgggtagtg gccgatttgc   2460

cttcagagtg acaggtagag aagggaagag cgtgtagaac tgtggccata ctttaggagt   2520

gtgagggatg ctgaatctcc cagagagctc acactggcca ggaatgctga gagtagcaga   2580

tgcttttctt ttgggaggat agtaaaacaa tttagaacca gatatgcttt gtcttgattc   2640

tcaagtagaa taatcttcaa atgcaaaaga atacattaga aatggacaaa agtggccagg   2700

agcggtagct catacttgta acccagcact ttgggaagcc gaggcgggct gatcgcttga   2760

ggtcaggagt tcgagaccag cctggccaaa atagtgaaac tcacgtttct actaaaaata   2820

caaaaattag ctgggtgtga tggccacttg ggaggctgag ataggagaat cgcttgaacc   2880

tgggaggcag aggttgcagt gagccaatat cgtgccactg cattccagcc tgggtgacag   2940

aatgaaactc catcactcca tctcaaaaaa aaaaaaaaaa aaaaaaaaaa              2990


<210>  528
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  528

Met Glu Val Cys Tyr Gln Leu Pro Val Leu Pro Leu Asp Arg Pro Val 
1               5                   10                  15


Pro Gln His Val Leu Ser Arg Arg Gly Ala Ile Ser Phe Ser Ser Ser 
            20                  25                  30


Ser Ala Leu Phe Gly Cys Pro Asn Pro Arg Gln Leu Ser Gln Arg Arg 
        35                  40                  45


Gly Ala Ile Ser Tyr Asp Ser Ser Asp Gln Thr Ala Leu Tyr Ile Arg 
    50                  55                  60


Met Leu Gly Asp Val Arg Val Arg Ser Arg Ala Gly Phe Glu Ser Glu 
65                  70                  75                  80


Arg Arg Gly Ser His Pro Tyr Ile Asp Phe Arg Ile Phe His Ser Gln 
                85                  90                  95


Ser Glu Ile Glu Val Ser Val Ser Ala Arg Asn Ile Arg Arg Leu Leu 
            100                 105                 110


Ser Phe Gln Arg Tyr Leu Arg Ser Ser Arg Phe Phe Arg Gly Thr Ala 
        115                 120                 125


Val Ser Asn Ser Leu Asn Ile Leu Asp Asp Asp Tyr Asn Gly Gln Ala 
    130                 135                 140


Lys Cys Met Leu Glu Lys Val Gly Asn Trp Asn Phe Asp Ile Phe Leu 
145                 150                 155                 160


Phe Asp Arg Leu Thr Asn Gly Asn Ser Leu Val Ser Leu Thr Phe His 
                165                 170                 175


Leu Phe Ser Leu His Gly Leu Ile Glu Tyr Phe His Leu Asp Met Met 
            180                 185                 190


Lys Leu Arg Arg Phe Leu Val Met Ile Gln Glu Asp Tyr His Ser Gln 
        195                 200                 205


Asn Pro Tyr His Asn Ala Val His Ala Ala Asp Val Thr Gln Ala Met 
    210                 215                 220


His Cys Tyr Leu Lys Glu Pro Lys Leu Ala Asn Ser Val Thr Pro Trp 
225                 230                 235                 240


Asp Ile Leu Leu Ser Leu Ile Ala Ala Ala Thr His Asp Leu Asp His 
                245                 250                 255


Pro Gly Val Asn Gln Pro Phe Leu Ile Lys Thr Asn His Tyr Leu Ala 
            260                 265                 270


Thr Leu Tyr Lys Asn Thr Ser Val Leu Glu Asn His His Trp Arg Ser 
        275                 280                 285


Ala Val Gly Leu Leu Arg Glu Ser Gly Leu Phe Ser His Leu Pro Leu 
    290                 295                 300


Glu Ser Arg Gln Gln Met Glu Thr Gln Ile Gly Ala Leu Ile Leu Ala 
305                 310                 315                 320


Thr Asp Ile Ser Arg Gln Asn Glu Tyr Leu Ser Leu Phe Arg Ser His 
                325                 330                 335


Leu Asp Arg Gly Asp Leu Cys Leu Glu Asp Thr Arg His Arg His Leu 
            340                 345                 350


Val Leu Gln Met Ala Leu Lys Cys Ala Asp Ile Cys Asn Pro Cys Arg 
        355                 360                 365


Thr Trp Glu Leu Ser Lys Gln Trp Ser Glu Lys Val Thr Glu Glu Phe 
    370                 375                 380


Phe His Gln Gly Asp Ile Glu Lys Lys Tyr His Leu Gly Val Ser Pro 
385                 390                 395                 400


Leu Cys Asp Arg His Thr Glu Ser Ile Ala Asn Ile Gln Ile Gly Asn 
                405                 410                 415


Tyr Thr Tyr Leu Asp Ile Ala Gly 
            420


<210>  529
<211>  3669
<212>  DNA
<213>  Homo sapiens

<400>  529
gcccaggtaa agccatgttt tcctacactt aaaaatgtaa ataaatatcc cttagataat     60

ctggacagca gtttcttata tagcatgtct gagcactata ttttgctggg ctataaaagg    120

tttaattgtt gtttattggt acaataaggg attctagtta ctaatatcta cctgtagtca    180

ataaagcaaa cattgattgg ttgatcgaat cattgattca ttcaataggt attgattcag    240

caccagctat gagctaggca gagttctagg ccctacagag aaaactgata tcaaactaag    300

aaagtctttt tccaagtgct acagtagggg tgggggagga gagagataac aaactggtga    360

gcaaatgtta aacaaaatga ttctagagag tgctaaatac tgtgaggaag ataaaatgat    420

aaaataataa agacttctga agattggtta gggtaacctc ttgtagaagt atcattggag    480

accgaaggat gacacaccag ccatctgacc atgagagaac atcattcaag gcaaaggaaa    540

cagaccacca ccaacaaaaa aagatgcact ggggaatttc cagtaacact tttgttagct    600

ctcttaatat ctgatttttt gagcactaga acactgcctc tcacagaatc ctagcttaaa    660

acagcaatga acagactaga attctaggct aaaaccaaca agatgaaatg tgactgatat    720

gaatataaat ggtgcacata agttcacaaa cccaattaca cagcacaaaa tgatatccac    780

gtggcttgac agctgttcat attagaaaaa tctagggatt ctaatggact acatattgga    840

gattgctctt tgctgttcct gactggaaaa aaaaatatgt agatattacc cttgggcaga    900

tttcagccca acttaaagta tcattagagc tgtccaaaat ggaacagcct gctttgcaca    960

tagagaactc acattgctca actcaaaaaa gagcagaagg aaggaagaag gaaggacacg   1020

taacagggat ttttacaaaa acagaattcg gtatttcttg gagactactt taagacagtt   1080

tttggtttct gtaagtctgt gacttattac ttattccttt aattccaata aaattttctt   1140

catttttgtt atttttaaaa cattaagaag aaaaaaatga tattgatata aggtagatgg   1200

tgaagtttag caaaagttta gtttataatg atatctctca aaatagcaaa ctgaagttta   1260

aaattcttaa gctataattt taaaggaatt tagattaaac ttttaatatg ttgttggcta   1320

agtataatac aaaataaaaa ctaaataaat cttggttttg ccacatatta gctgtgtaat   1380

atagacaatt tacttctctg ttattgtttc ctcagaatga gggcagtaac ttgtagccgt   1440

ctgaaaagat tgttataagc atggagttag ttgctgtata taaagcagtt agaccagtac   1500

ctgacaatat tacatgctaa gtaagtgctt gctattactg ttgctgttat tattaattat   1560

aattgtgtgc tctattctgc cttcaggaat taatgaccaa gttaataact gagacacctg   1620

accagccaat cccatttctc attgaccatc ttcagtctaa acaagggaac cgtggacaac   1680

ttcaaagaac tttgtctgga tctgcagctc tatgggcaga aagtgaaaaa tcagaatcca   1740

aaggaacaag aagggatttc agaagctatg ataaaccttg gcaattaaat gcaaagaagc   1800

ctaaaaaatc aaaaagtgac cttgctgtgt ctaatatttc tccaccatca ccggactcca   1860

aatcattgcc aaggtcagta gagcatccaa agtggaactg gaggactaaa ccacaaagcc   1920

gtgattttga tgaattgaat cacatccttc aggagagcaa gaagctgggg aaagcccttg   1980

agaatctctc tcgaagtatt gcaatttcag atgaactcga taaggaaaca gtgacattta   2040

attcttctct tctgaggccc cgtgtgattg gagaatggat tggtagagaa gaaaatgatg   2100

ctgatcccct agctgctgaa atgctacagc ctccaattcc aagaagcaaa aatgaccaat   2160

gggaaagtga agatagtggc tctagtcctg caggaagctt aaagatggag cctaagaaca   2220

aaggattaaa acagcagcaa cagcaacata agaaactcct ggccgcaatg ctctctcaag   2280

attcttttga gtccatccac agccctaccc catctgtaac agaagaagat attgataatg   2340

aagatgatgc aatggaattg ctggaggatc ttaatgattt aagaatggag ggagtaacaa   2400

ccctggtacc ttctgggagc aaatttaacc aaggccgtcc tacttaccct gctgagcctc   2460

aggccaaggt cacactgaac atctgttcaa ggtgtgccag gcttcaagga gacaacctgg   2520

aagaaaggac agaagagtca ctaccaatac tccattctcc agatgaaaaa atcccagatt   2580

cattcgattc cttgcctggg actgaagaag cactaatgga ggagggtgac gaatttgaga   2640

aagcatctaa actaacagga cctggagaag cctccagtgg agtaggacac tcactgaaaa   2700

actacatgga agaagatgaa tccttaaagc aattgcaggt agttcatcaa ccatggatct   2760

tgccaagtga cacagaaagt gaaggagtgg aagcagaaca agagaaacgt tccgctgatc   2820

ttcttctttg cgttccatgc tcttcttgtc ctacgctggt ctactctggt ttgtgaaaca   2880

gagagaagaa gttgcaagtg gtccttaaag aaatgcagtt attcaaatcc ttatgtatag   2940

ttctaatttt atttactatg tgtaatcatt tagagaatgg ttatttttat aatctcaata   3000

ataaacaagt actatcgtag ccagggggtg cccaagtatg taatcagaga acactaatcc   3060

tggcaaagga ttgtggggtg gtcaggaggc cggctgcctt ttgacatggt tagagtcctg   3120

ggtttagatt actttataaa tagttattaa gattaatatt tgatatatta aatattgcct   3180

gattcaaata actttgctta aaatttttct gtattttaac ttgtctaggg ttttctactt   3240

cttctatttt tataatattt tctcattttt tagattacta aacattctac ttatccacat   3300

gtgccaagat gtgccattta ggtctctgca gaaattagct gtttggtatc atcacctgcc   3360

atacatgttg tgtgcagcag tgagaagtat attctctacc actgctcttt ctcatgatta   3420

ttttctctat tcctattaaa atgaataatt gatatgttaa ttaagtaaag caaatcaata   3480

aggaatgaaa tgcatggccc aaaacataga aaatgaaaat cgtttgacca tttatccaat   3540

tattgaaccc aattaagatg atccatttta aatttaatat atgctcgctt ttggaatgtg   3600

ttatgcattg atgttaagtg aatggatcta agtaaatcta ttgatatctc taaaaaaaaa   3660

aaaaaaaaa                                                           3669


<210>  530
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  530

Met Thr Lys Leu Ile Thr Glu Thr Pro Asp Gln Pro Ile Pro Phe Leu 
1               5                   10                  15


Ile Asp His Leu Gln Ser Lys Gln Gly Asn Arg Gly Gln Leu Gln Arg 
            20                  25                  30


Thr Leu Ser Gly Ser Ala Ala Leu Trp Ala Glu Ser Glu Lys Ser Glu 
        35                  40                  45


Ser Lys Gly Thr Arg Arg Asp Phe Arg Ser Tyr Asp Lys Pro Trp Gln 
    50                  55                  60


Leu Asn Ala Lys Lys Pro Lys Lys Ser Lys Ser Asp Leu Ala Val Ser 
65                  70                  75                  80


Asn Ile Ser Pro Pro Ser Pro Asp Ser Lys Ser Leu Pro Arg Ser Val 
                85                  90                  95


Glu His Pro Lys Trp Asn Trp Arg Thr Lys Pro Gln Ser Arg Asp Phe 
            100                 105                 110


Asp Glu Leu Asn His Ile Leu Gln Glu Ser Lys Lys Leu Gly Lys Ala 
        115                 120                 125


Leu Glu Asn Leu Ser Arg Ser Ile Ala Ile Ser Asp Glu Leu Asp Lys 
    130                 135                 140


Glu Thr Val Thr Phe Asn Ser Ser Leu Leu Arg Pro Arg Val Ile Gly 
145                 150                 155                 160


Glu Trp Ile Gly Arg Glu Glu Asn Asp Ala Asp Pro Leu Ala Ala Glu 
                165                 170                 175


Met Leu Gln Pro Pro Ile Pro Arg Ser Lys Asn Asp Gln Trp Glu Ser 
            180                 185                 190


Glu Asp Ser Gly Ser Ser Pro Ala Gly Ser Leu Lys Met Glu Pro Lys 
        195                 200                 205


Asn Lys Gly Leu Lys Gln Gln Gln Gln Gln His Lys Lys Leu Leu Ala 
    210                 215                 220


Ala Met Leu Ser Gln Asp Ser Phe Glu Ser Ile His Ser Pro Thr Pro 
225                 230                 235                 240


Ser Val Thr Glu Glu Asp Ile Asp Asn Glu Asp Asp Ala Met Glu Leu 
                245                 250                 255


Leu Glu Asp Leu Asn Asp Leu Arg Met Glu Gly Val Thr Thr Leu Val 
            260                 265                 270


Pro Ser Gly Ser Lys Phe Asn Gln Gly Arg Pro Thr Tyr Pro Ala Glu 
        275                 280                 285


Pro Gln Ala Lys Val Thr Leu Asn Ile Cys Ser Arg Cys Ala Arg Leu 
    290                 295                 300


Gln Gly Asp Asn Leu Glu Glu Arg Thr Glu Glu Ser Leu Pro Ile Leu 
305                 310                 315                 320


His Ser Pro Asp Glu Lys Ile Pro Asp Ser Phe Asp Ser Leu Pro Gly 
                325                 330                 335


Thr Glu Glu Ala Leu Met Glu Glu Gly Asp Glu Phe Glu Lys Ala Ser 
            340                 345                 350


Lys Leu Thr Gly Pro Gly Glu Ala Ser Ser Gly Val Gly His Ser Leu 
        355                 360                 365


Lys Asn Tyr Met Glu Glu Asp Glu Ser Leu Lys Gln Leu Gln Val Val 
    370                 375                 380


His Gln Pro Trp Ile Leu Pro Ser Asp Thr Glu Ser Glu Gly Val Glu 
385                 390                 395                 400


Ala Glu Gln Glu Lys Arg Ser Ala Asp Leu Leu Leu Cys Val Pro Cys 
                405                 410                 415


Ser Ser Cys Pro Thr Leu Val Tyr Ser Gly Leu 
            420                 425


<210>  531
<211>  390
<212>  DNA
<213>  Homo sapiens

<400>  531
atggtgcaca tgaatgtctt ggttgatatt ctcaggaaca tccacaatgc taaaaagaga     60

gacaaacacc aggttcttat caagccatgc tccagagtta tcatcctgtt tctcactgtg    120

atgaagcatg gctacactgg tgaatctaaa atcattgatg atcacagagc tgggaagatt    180

gttgtgaacc tcacaggcag gctaaacaaa tatggagtga tcagccccag gtttcatgtg    240

caactcaaag atctagaaaa atggcagcat aatctgctcc catctgacca gttcggtttc    300

attgtactga caacctcagc tggcatcatg gaccacaaag aagtaagacg aagacacaca    360

ggagggaaaa tcctgggatt ctttttctag                                     390


<210>  532
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  532

Met Val His Met Asn Val Leu Val Asp Ile Leu Arg Asn Ile His Asn 
1               5                   10                  15


Ala Lys Lys Arg Asp Lys His Gln Val Leu Ile Lys Pro Cys Ser Arg 
            20                  25                  30


Val Ile Ile Leu Phe Leu Thr Val Met Lys His Gly Tyr Thr Gly Glu 
        35                  40                  45


Ser Lys Ile Ile Asp Asp His Arg Ala Gly Lys Ile Val Val Asn Leu 
    50                  55                  60


Thr Gly Arg Leu Asn Lys Tyr Gly Val Ile Ser Pro Arg Phe His Val 
65                  70                  75                  80


Gln Leu Lys Asp Leu Glu Lys Trp Gln His Asn Leu Leu Pro Ser Asp 
                85                  90                  95


Gln Phe Gly Phe Ile Val Leu Thr Thr Ser Ala Gly Ile Met Asp His 
            100                 105                 110


Lys Glu Val Arg Arg Arg His Thr Gly Gly Lys Ile Leu Gly Phe Phe 
        115                 120                 125


Phe 



<210>  533
<211>  4058
<212>  DNA
<213>  Homo sapiens

<400>  533
ccaatgttgg agccgtctgc aaagtgtccc cggcaagaag aggctgccta ccacaaggac     60

tttagcttac tttttaaaga ttgaagaaaa aaaagaagac agaaaaagaa gaactcaaag    120

atacacaaag taatttgaac caaggctcag aagtttttgg agccgtgagg gatacagcag    180

tttggtcaat attgtcttaa catgcttcaa ataaatcaga tgttctcagt gcagctgagt    240

cttggtgagc agacatggga atccgaaggc agcagtataa agaaggctca gcaggctgtt    300

gccaataaag ctttgactga atctacgctt cccaaaccag ttcagaagcc acccaaaagt    360

aatgttaaca ataacccagg cagtataact ccaactgtgg aactgaatgg gcttgctatg    420

aaaaggggag agcctgccat ctacaggcca ttagatccaa agccattccc aaattataga    480

gctaattaca actttcgggg catgtacaat cagaggtatc attgcccagt gcctaagatc    540

ttttatgttc agctcactgt aggaaataat gaattttttg gggaaggaaa gactcgacaa    600

gctgctagac acaatgctgc aatgaaagcc ctccaagcac tgcagaatga acctattcca    660

gaaagatctc ctcagaatgg tgaatcagga aaggatatgg atgatgacaa agatgcaaat    720

aagtctgaga tcagcttagt gtttgaaatt gctctgaagc gaaatatgcc tgtcagtttt    780

gaggttatta aagaaagtgg accaccacat atgaaaagct ttgttactcg agtgtcagta    840

ggagagttct ctgcagaagg agaaggaaat agcaaaaaac tctccaagaa gcgcgctgcg    900

accaccgtct tacaggagct taaaaaactt ccacctcttc ctgtggtgga aaagccaaaa    960

ctatttttta aaaaacgccc taaaacaata gtaaaggccg gaccagaata tggccaaggg   1020

atgaacccta ttagccgcct ggcgcaaatt caacaggcca aaaaggaaaa ggagccggat   1080

tatgttttgc tttcagaaag aggaatgcct cgacgtcgag aatttgtgat gcaggtgaag   1140

gtaggcaatg aagttgctac aggaacagga cctaataaaa agatagccaa aaaaaatgct   1200

gcagaagcaa tgctgttaca acttggttat aaagcatcca ctaatcttca ggatcaactt   1260

gagaagacag gggaaaacaa aggatggagt ggtccaaagc ctgggtttcc tgaaccaaca   1320

aataatactc caaaaggaat tcttcatttg tctcctgatg tttatcaaga gatggaagcc   1380

agccgccaca aagtaatctc tggcactact ctaggctatt tgtcacccaa agatatgaac   1440

caaccttcaa gctctttctt cagtatatct cccacatcga atagttcagc tacaattgcc   1500

agggaactcc ttatgaatgg aacatcttct acagctgaag ccataggttt aaaaggaagt   1560

tctcctactc ccccttgttc tccagtacaa ccttcaaaac aactggaata tttagcaagg   1620

attcaaggct ttcaggtatg aattaaaagc aaaaacaaaa aacaaaacaa ttcattagcc   1680

tcagattctt catctgtata catcacaagg ctcattcttg cctgctagta tggcctacat   1740

gccacttacg ttttaagtta tttaggaaca caaaggacag acaaaaaagc catatgcaca   1800

tgcctcattt tctcttattt ttgatctatc tagtaattct tttgctgcct gtctcttctc   1860

cattttcctt cttctttttt aagcattttt catattcttc actgtcttct atttggtctt   1920

gattaggtgc atctatctct tcgctctgtc ttccacaaac aaaaattctg ccttcagaca   1980

tttggtgtta gtatttcaca ctcagttctc ccttttttta cataaggatt gagtttcttt   2040

ttatgatgat tttaccttta tagcaatttt gaattttgca ttctgttgct agtattgatt   2100

caggtacacc attaagatac aacattctag aagtctatta ccttaggagt taattaaaca   2160

tgatatttga agaataatga aatgctttat agttgtttga ggcataacaa tgtgtatttg   2220

ttttactgga tcatgttttg aactgactag ggagggtagc acctgcctca gatagtacca   2280

acaattctgt ttcactgggt agtctaaaac tagcttatag tttaacttaa cttgttgtgt   2340

atgtgaattt agggatggaa actttttttc ccctatttat tctttgtttc cttctgggaa   2400

aaaaccccac aaaaatcagc actcctttat ggatacattg gagcttttga aagaattgta   2460

aactctagga aggggaaata tctgtgtctt gatttcttag ttgccttgaa aatcatgtac   2520

tgaactgtaa ccgctaactt gactggatga actagtttgc ttgtgtgtag agagtgtatt   2580

gcttcctcag atttcactgt tttcatctcc ttttccatct tagtctttat tccttaagac   2640

caaaaactgt aatatccttt agaaatgctc tagaagatct gtattgtgta gaatgatcat   2700

gtatttataa atattttaca agtttagatt ataaaatgaa aaagaaggtc atgtgttttg   2760

gggggtattt tgcatgttcg gatttttttt tcccttcacc gaacccttct gattctttca   2820

aactattgcc aggtagttgt tagtgtttct aattggactc ttaatatgaa cttcaagaag   2880

ctgttaccag ttatcggctc tgtcatctga aattttaacc acttaattta aagttacaat   2940

tttagaattt gtttttgttg ttttacctta agaaacacaa taaatcactg tttaaaaaag   3000

atctcaattt atataaagta ctggaaaaaa gctaagtaat ttttagttct atctataatc   3060

tccgtaggat gaattagaaa taaattgtga tgaaaagaaa ttaactgctt atttatgaat   3120

ctaatcattt agaaatgtct gagagtaaca ctgcattctt atagaaacaa agcacaaatt   3180

gcattcaagc tctgaattga ttttttgctt ggagctgttg ttacagtagc tgtaattttg   3240

ctaccagaat gtcttaattt tttaaatttg tttttatttc taagctcttg gcaatgacaa   3300

taattataat tttaacatat cttcactgta gtcaacatgt agagtctgct tccctcatta   3360

ttgcattgct aaggcctttt taaaaagctt atgcttacat aatatactct tttttatgga   3420

cacgttatat gtttccaaat ctgtgtattg tgatttttac atactaatga atataaacag   3480

gtgattttaa aatattactg tgcttctttg gttgaatgag ctggtattga tgtaaaatac   3540

tctgtcattg atggaccact acctgcagct aagcagtgag cagaatctcc gggaaatgac   3600

ttagtctggc cacatgcata gcccatcttc ataatgtcgc agcagaaggt tctttgtggt   3660

taaaagtttt aaagcctatt tctttatagg taaccctctc aggtatattt acctggtaga   3720

aaaacatgta gattgtttct attacttaaa tgttttaatt ggactgtagt ttagaaatta   3780

caggaccagc ttgttacaga ttatacacta ttctgttact tttatttctg aaacttaaaa   3840

acaataaatt ctttttctgt gtttctaggt tagaactttt ttattttatt gcacactgaa   3900

cagatactgt tgcttattga atattgtgta aacccttctt tggctttcct tgcccattgc   3960

aatttgattt aagcctacta gagccattgt atgtgacagc tatattgtat tacaaagtaa   4020

aaatatatga gtgtattgaa aaaaaaaaaa aaaaaaaa                           4058


<210>  534
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  534

Met Leu Gln Ile Asn Gln Met Phe Ser Val Gln Leu Ser Leu Gly Glu 
1               5                   10                  15


Gln Thr Trp Glu Ser Glu Gly Ser Ser Ile Lys Lys Ala Gln Gln Ala 
            20                  25                  30


Val Ala Asn Lys Ala Leu Thr Glu Ser Thr Leu Pro Lys Pro Val Gln 
        35                  40                  45


Lys Pro Pro Lys Ser Asn Val Asn Asn Asn Pro Gly Ser Ile Thr Pro 
    50                  55                  60


Thr Val Glu Leu Asn Gly Leu Ala Met Lys Arg Gly Glu Pro Ala Ile 
65                  70                  75                  80


Tyr Arg Pro Leu Asp Pro Lys Pro Phe Pro Asn Tyr Arg Ala Asn Tyr 
                85                  90                  95


Asn Phe Arg Gly Met Tyr Asn Gln Arg Tyr His Cys Pro Val Pro Lys 
            100                 105                 110


Ile Phe Tyr Val Gln Leu Thr Val Gly Asn Asn Glu Phe Phe Gly Glu 
        115                 120                 125


Gly Lys Thr Arg Gln Ala Ala Arg His Asn Ala Ala Met Lys Ala Leu 
    130                 135                 140


Gln Ala Leu Gln Asn Glu Pro Ile Pro Glu Arg Ser Pro Gln Asn Gly 
145                 150                 155                 160


Glu Ser Gly Lys Asp Met Asp Asp Asp Lys Asp Ala Asn Lys Ser Glu 
                165                 170                 175


Ile Ser Leu Val Phe Glu Ile Ala Leu Lys Arg Asn Met Pro Val Ser 
            180                 185                 190


Phe Glu Val Ile Lys Glu Ser Gly Pro Pro His Met Lys Ser Phe Val 
        195                 200                 205


Thr Arg Val Ser Val Gly Glu Phe Ser Ala Glu Gly Glu Gly Asn Ser 
    210                 215                 220


Lys Lys Leu Ser Lys Lys Arg Ala Ala Thr Thr Val Leu Gln Glu Leu 
225                 230                 235                 240


Lys Lys Leu Pro Pro Leu Pro Val Val Glu Lys Pro Lys Leu Phe Phe 
                245                 250                 255


Lys Lys Arg Pro Lys Thr Ile Val Lys Ala Gly Pro Glu Tyr Gly Gln 
            260                 265                 270


Gly Met Asn Pro Ile Ser Arg Leu Ala Gln Ile Gln Gln Ala Lys Lys 
        275                 280                 285


Glu Lys Glu Pro Asp Tyr Val Leu Leu Ser Glu Arg Gly Met Pro Arg 
    290                 295                 300


Arg Arg Glu Phe Val Met Gln Val Lys Val Gly Asn Glu Val Ala Thr 
305                 310                 315                 320


Gly Thr Gly Pro Asn Lys Lys Ile Ala Lys Lys Asn Ala Ala Glu Ala 
                325                 330                 335


Met Leu Leu Gln Leu Gly Tyr Lys Ala Ser Thr Asn Leu Gln Asp Gln 
            340                 345                 350


Leu Glu Lys Thr Gly Glu Asn Lys Gly Trp Ser Gly Pro Lys Pro Gly 
        355                 360                 365


Phe Pro Glu Pro Thr Asn Asn Thr Pro Lys Gly Ile Leu His Leu Ser 
    370                 375                 380


Pro Asp Val Tyr Gln Glu Met Glu Ala Ser Arg His Lys Val Ile Ser 
385                 390                 395                 400


Gly Thr Thr Leu Gly Tyr Leu Ser Pro Lys Asp Met Asn Gln Pro Ser 
                405                 410                 415


Ser Ser Phe Phe Ser Ile Ser Pro Thr Ser Asn Ser Ser Ala Thr Ile 
            420                 425                 430


Ala Arg Glu Leu Leu Met Asn Gly Thr Ser Ser Thr Ala Glu Ala Ile 
        435                 440                 445


Gly Leu Lys Gly Ser Ser Pro Thr Pro Pro Cys Ser Pro Val Gln Pro 
    450                 455                 460


Ser Lys Gln Leu Glu Tyr Leu Ala Arg Ile Gln Gly Phe Gln Val 
465                 470                 475


<210>  535
<211>  2302
<212>  DNA
<213>  Homo sapiens

<400>  535
atggtcgcgc gtcccctgca cagcacagag gggcagccgg agagcctggg aaaggtacga     60

gcggggaatc agagcacagg gtgcggacca gaaagagcag acggtcagtc gggcggggaa    120

ggaagttgcc gagttgcagg tgtggaaggg gctgccccag gcccaccctt ggcagacgag    180

ggggcgggga gtcgcgccgg ggacgaggag actgcggacc gggcgcgctc cttgcgcagt    240

cgctcgcccg cgtgcccaag ccccccggga atggccctcg cccaggggcc cagctcgccg    300

ccgctagccc cgcagagcct gcagctgctg gggcccggca gccgccaggg ggcgggagct    360

gcgtcgcgaa caatggccgc gcttgttctc tgtagtgttt gccaatgttg gagccgtctg    420

caaagtgtcc ccggcaagaa ggtaaatacc ctcatcgggg gcgtccggga gaccccgact    480

tccgcgccgc cggcgaagaa ggcagagggc gctggggagc cctgcagttc cgcagcacgg    540

ggaacccgga gaaaagcagc ccccttcgcg gcctcccctc ccccgcgcct tccctcccac    600

atcgggctct cggggcagca gcggggaggg gagaccggcg ggggagggag gacagggagg    660

cgaaggaatt ggggtggggg gtgcgtgtgt ggtggagggg gtgggacgac acaggtgtcc    720

tgaggggagg agccgggagg aaggcgagga ggccgggcca agtgggggtg cggaggtcgg    780

ggagacagga acgcggctgc gggcgcggga ggctggggtt ctagggggcc ggggtggtag    840

cggccggaag agaggacggc gagtgcagcc acggtgtggc tgcgagggag agggagcgcc    900

tagagtaggg caggggaggg cggcccgggg agggtctgcg ggaaatgggc ctgggggcgc    960

tggaggcgga gcggcggggc cggggcgcgc cggagggtgg cggcggcagc tatttctgta   1020

gaatgggcta gtggtaaaga cgtaacttgc cgaaatgggg agggtaggtg gggccgaggg   1080

gacaaaatat atcctatgac aggcaagttc tgctgtggct gttacgaact cctaccgtga   1140

tggctcggct taaaggggta gttggcggta gtgaccttgc cggggtgaag ggagttgggc   1200

gaggagacaa agctcagtta cggaatccgc tgtgtgagag caggaactct agtctcttcg   1260

gggtcgagcc gggggctgtg gcttgggggc tgggggtgct ccgcagaggc cattgagaag   1320

cacgccactc tgggattctt agggaggcgg tgggggtaat ggccgtggga ttctggaagt   1380

ctttggaaat gtgtgtagaa ttttgcattt gtgaataatt ttctttggta agggtccata   1440

tttgctgtga tgtcccctta cccccatccc cactccaaag ggttaagaac tgcttgagca   1500

gatagagagg gaccattcaa ttagggtaga cctgggaatt taccaaagga ttttaaagtg   1560

ggtggatcct gcagaaagaa aggctagaga tgatccttta aagatatttt actgttaatt   1620

gaaaacgttt tttatttaat gtttgctttc acaattttgg tgaacttttg ctgagcatta   1680

cttggcttct gatgcatcct gtgtttcaga ccagcatcgt gaatacttga aatcaaaatt   1740

gtgatggaca ggcagggtga tagtaacctt ggaggagaaa agatttcaac atttctccag   1800

gatatttctt ccccgtcctt gctttcttta gatgattcaa gtacactgtt gtgaactcag   1860

ctgcggtgga aaaatcttat ttaataaaac taccaaaacc aagacttact ctccatctct   1920

gttttgtagt atggccagat tttcattgtt cagtttgtat cttactgcaa acaagagata   1980

tcacataaca ctttaattgt agattgctgc attttgcagc aggcctgtat taaatttgcg   2040

aagcagttat gccaaactat ctggtgtgtt tgtgttttcc tgctatggtt tcaagtcaag   2100

tcactattgc catattttat tatatggtag gctagtctga aatttattcc taagtgatga   2160

taagttggta ggatatggta catacttgct cacaaattac tgcatttttc cccataaaaa   2220

ccagtgtttt gtatttgtaa gaatgttgct gtgtaatcca agtatgtatt gttaatttca   2280

aataaaatgc tgtgtaattt tt                                            2302


<210>  536
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  536

Met Val Ala Arg Pro Leu His Ser Thr Glu Gly Gln Pro Glu Ser Leu 
1               5                   10                  15


Gly Lys Val Arg Ala Gly Asn Gln Ser Thr Gly Cys Gly Pro Glu Arg 
            20                  25                  30


Ala Asp Gly Gln Ser Gly Gly Glu Gly Ser Cys Arg Val Ala Gly Val 
        35                  40                  45


Glu Gly Ala Ala Pro Gly Pro Pro Leu Ala Asp Glu Gly Ala Gly Ser 
    50                  55                  60


Arg Ala Gly Asp Glu Glu Thr Ala Asp Arg Ala Arg Ser Leu Arg Ser 
65                  70                  75                  80


Arg Ser Pro Ala Cys Pro Ser Pro Pro Gly Met Ala Leu Ala Gln Gly 
                85                  90                  95


Pro Ser Ser Pro Pro Leu Ala Pro Gln Ser Leu Gln Leu Leu Gly Pro 
            100                 105                 110


Gly Ser Arg Gln Gly Ala Gly Ala Ala Ser Arg Thr Met Ala Ala Leu 
        115                 120                 125


Val Leu Cys Ser Val Cys Gln Cys Trp Ser Arg Leu Gln Ser Val Pro 
    130                 135                 140


Gly Lys Lys Val Asn Thr Leu Ile Gly Gly Val Arg Glu Thr Pro Thr 
145                 150                 155                 160


Ser Ala Pro Pro Ala Lys Lys Ala Glu Gly Ala Gly Glu Pro Cys Ser 
                165                 170                 175


Ser Ala Ala Arg Gly Thr Arg Arg Lys Ala Ala Pro Phe Ala Ala Ser 
            180                 185                 190


Pro Pro Pro Arg Leu Pro Ser His Ile Gly Leu Ser Gly Gln Gln Arg 
        195                 200                 205


Gly Gly Glu Thr Gly Gly Gly Gly Arg Thr Gly Arg Arg Arg Asn Trp 
    210                 215                 220


Gly Gly Gly Cys Val Cys Gly Gly Gly Gly Gly Thr Thr Gln Val Ser 
225                 230                 235                 240


<210>  537
<211>  4057
<212>  DNA
<213>  Homo sapiens

<400>  537
agctcctccc cctgcgtctc tggcctcgcc ggtcttgggg ggatggttcc atcatggcgt     60

caatgcagac cacaggaagg agggtggaag tatggtttcc aaaacgacta cagaaagaac    120

tgttggcttt gcaaaatgac ccacctcctg gaatgacctt aaatgagaag agtgttcaaa    180

attcaattac acagtggatt gtagacatgg aaggtgcacc aggtacctta tatgaagggg    240

aaaaatttca acttctattt aaatttagta gtcgatatcc ttttgactct cctcaggtca    300

tgtttactgg tgaaaatatt cctgttcatc ctcatgttta tagcaatggt catatctgtt    360

tatccattct aacagaagac tggtccccag cgctctcagt ccaatcagtt tgtcttagca    420

ttattagcat gctttccagc tgcaaggaaa agagacgacc accggataat tctttttatg    480

tgcgaacatg taacaagaat ccaaagaaaa caaaatggtg gtatcatgat gatacttgtt    540

gatgccactg ttatcatcct cctagcagaa gatagtccta ctgagaaaat gagcactttg    600

atcattcagt ctttgaactt taacctttga ctggaagtga cctataggca atgaagacta    660

cttcctttta ctgcattttt actcgtgtgc attctgggcg catgttgatc gctggttcag    720

tccaggcaac tgacatgctt ttattagtca tacagtatta atgcaggtgt caggaaatgt    780

caaatataat tccatttttt atttttattt ttttaagctt ttggaaaagc tccaggtcct    840

catgtattgt gcaataacaa tgacttcctt ggcggttttg gtacgttcat tgccggcaat    900

gggcgttgta acaggaaaag ttttcattaa ctcctgccat tcaatgatta atgcatgata    960

gggcctatga aatgaactta ctggttatag tgggaatata aataaagtga gggatccaac   1020

attactttaa aagtcacccc aactgtttat atttggattc tatgcactgt gatcctaagg   1080

ttaacagcat gaattaacat gcgtctttaa aggactgtaa tgaaagatca ttgcatattt   1140

attgaattgt ttatatctac tgtcaagttg ttttgacatg gaagattttc aagtaacatt   1200

ggcagagagg tacagtatgt tatccctatg gtgaaaataa attaatttgt tgtatatagt   1260

tcctcaatct ctgaagtaaa ggtatgagta atatagggta tgaatggttt aatcaaggct   1320

ttattttgga agtaagaaaa atggcagtga tgattaaatt gctgcagtcc ataatttggg   1380

cttgttattt gtacattaaa gattttttcc aagtaagtta cactctgtta acttcctgct   1440

agccatcagc atgagcccta ctgcctaaac actatttcat ttatttatgt ttggaaaccc   1500

cgtaaacatt tttgtttgca atcttgtttc ttttgttata agtcaagttt gaatgttaca   1560

atacttttat tgaaactttt gttaagtttt ttcttgtaaa ttttctttac ttgtgagtat   1620

catcttgtcc tttaatcctg taccctaaaa taagaaatac atttttgaca gaggcttaat   1680

gttttaacaa aagagtgtgg acatttttat tttaaaattt aggcaaaagt cactatcaaa   1740

tggttgctta tttgtctcac acagccatat agtttttcct ggagggtttt gttttgttgt   1800

tgttgaaaag actttgctta cagctagatg aaactttcta tagaaaaaaa aaattgttga   1860

aaggtccagt tctcagtacc atgtgagtta atgatactac aactaagttc tttttaaaaa   1920

gtgattaatg tattttataa attacctttt cacatatgca aaatctgttt ctactacaat   1980

gttattttta ctaatgcctt attgttgcac tctttttgaa atatcctgca gtgaatatat   2040

gaatcaattt gggcttaaaa ctgaaagcca gttggctgaa aggtttgaaa tacgtacccc   2100

agtaaaacca ttcaatcaat aattggtaaa taatatttta aaattgtttt taatctgtat   2160

agatgacatt ttgtagcttt gtacatgttg ttaattaagg gcatataatt ttacactcaa   2220

agtataattg ctgaactcag gggtgggtag acttcaaaaa tatgtctgct atagaaataa   2280

cttgaaaaaa aaaattaaaa ccgtggccag ccaccaaatt gtggacactg tttatatact   2340

gctagttaac aattaccact tttaaaaaat tataaccgtt tttgttctat cttgactaga   2400

taaattctca caatgatctc tgtcagtttt attagttggc ctgtttaacc aagacagaaa   2460

gtctttgaat tactcatagt tttaaactgc ttttaatatg aaaattgcag ctgtaaatta   2520

tgtattttca tattttgcgt aactgctcta cactactgtt tgacttgatc ttcttctggg   2580

ggttagggag aaatctgtct ccatattgct ggttctctta ccaaaatgct tttataaaga   2640

aatgaccggt gacatttatt caccaaagga attaatatac tgagtcaaag attaacaatg   2700

ctatactata gagtaatagg tcatatatag cctcaattga gttttttatg acaatatttt   2760

aacatacctc tctctctaca tataaatacc ataaagtaaa ctaaaatgac acagaggaaa   2820

gtagaggaaa atgaaataat ttcggtacat cttatggttt aaagagtaga aaataagatg   2880

aaatatccta aaatatagga gcacagacat ttaaaattca taatcaggct aacaacactc   2940

tcttgaattt aggaatcatt gaaaactcct tgcacttaga tttaatttat atgttagtta   3000

cattattaaa agtcataagg catttatctg agtcattgct ctacagagag caattaatgg   3060

cttgtaataa taaaaagaat atttctctgt aatgcattgt tgaaagacaa ccagaatatc   3120

aagaaaatgt atataggaat atgctacttg cctcctccct gcatttcctc gtggggcact   3180

atttgcgaca taggcctaca gaattagact ttcatactta gaagataagg tacactcttc   3240

ttcttttatt tatttattta tttattttta ggccattctt ctggtttgcc aaattctatt   3300

aagacagtga tacatttgct tccttattta tgcatgctta gatcatgaac atgatgccct   3360

tctttttttt ttttttcttt ggtcaagtag ggattaatgc cataggttta gagagaagga   3420

ttgttttcag tttttaagag aattttttaa aaatacattt tatggttctc ttaaggaatt   3480

aatattcact tctgaaggac ttacttgtaa tatataattt atcattttag ccagcaggga   3540

aataaatcat ttttaatccc cagaagaaag tgctggaaat agcttctata tagtcagcag   3600

ttcacctgga gaaagatctt aattccttgt tgttttgact aggaatatca atatttggta   3660

taaaataact agaatagttt attacctttt ccctcatgaa attttaaata tatgcaaata   3720

tatatatcat tagattcctg tggtggataa taatttcttc agattctaaa acaggtgtct   3780

agtgactgct taattgtttc caagttgcat caaagatgaa ttggtaaata atggaaatga   3840

gtagtgatat gaaaatggtt atgtaactac atattacttg tttctggtaa tcaagtctta   3900

ttttttaaaa gcctattgtt tttcagaatt gagatattta aaacttgtta taacttcttc   3960

ctaaaaatag aagagaagag gaggtactgt gtgttacaaa aattttttta aataaagaat   4020

tcagtgtcac tagttctaaa aaaaaaaaaa aaaaaca                            4057


<210>  538
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  538

Met Ala Ser Met Gln Thr Thr Gly Arg Arg Val Glu Val Trp Phe Pro 
1               5                   10                  15


Lys Arg Leu Gln Lys Glu Leu Leu Ala Leu Gln Asn Asp Pro Pro Pro 
            20                  25                  30


Gly Met Thr Leu Asn Glu Lys Ser Val Gln Asn Ser Ile Thr Gln Trp 
        35                  40                  45


Ile Val Asp Met Glu Gly Ala Pro Gly Thr Leu Tyr Glu Gly Glu Lys 
    50                  55                  60


Phe Gln Leu Leu Phe Lys Phe Ser Ser Arg Tyr Pro Phe Asp Ser Pro 
65                  70                  75                  80


Gln Val Met Phe Thr Gly Glu Asn Ile Pro Val His Pro His Val Tyr 
                85                  90                  95


Ser Asn Gly His Ile Cys Leu Ser Ile Leu Thr Glu Asp Trp Ser Pro 
            100                 105                 110


Ala Leu Ser Val Gln Ser Val Cys Leu Ser Ile Ile Ser Met Leu Ser 
        115                 120                 125


Ser Cys Lys Glu Lys Arg Arg Pro Pro Asp Asn Ser Phe Tyr Val Arg 
    130                 135                 140


Thr Cys Asn Lys Asn Pro Lys Lys Thr Lys Trp Trp Tyr His Asp Asp 
145                 150                 155                 160


Thr Cys 



<210>  539
<211>  4024
<212>  DNA
<213>  Homo sapiens

<400>  539
agctcctccc cctgcgtctc tggcctcgcc ggtcttgggg ggatggttcc atcatggcgt     60

caatgcagaa acgactacag aaagaactgt tggctttgca aaatgaccca cctcctggaa    120

tgaccttaaa tgagaagagt gttcaaaatt caattacaca gtggattgta gacatggaag    180

gtgcaccagg taccttatat gaaggggaaa aatttcaact tctatttaaa tttagtagtc    240

gatatccttt tgactctcct caggtcatgt ttactggtga aaatattcct gttcatcctc    300

atgtttatag caatggtcat atctgtttat ccattctaac agaagactgg tccccagcgc    360

tctcagtcca atcagtttgt cttagcatta ttagcatgct ttccagctgc aaggaaaaga    420

gacgaccacc ggataattct ttttatgtgc gaacatgtaa caagaatcca aagaaaacaa    480

aatggtggta tcatgatgat acttgttgat gccactgtta tcatcctcct agcagaagat    540

agtcctactg agaaaatgag cactttgatc attcagtctt tgaactttaa cctttgactg    600

gaagtgacct ataggcaatg aagactactt ccttttactg catttttact cgtgtgcatt    660

ctgggcgcat gttgatcgct ggttcagtcc aggcaactga catgctttta ttagtcatac    720

agtattaatg caggtgtcag gaaatgtcaa atataattcc attttttatt tttatttttt    780

taagcttttg gaaaagctcc aggtcctcat gtattgtgca ataacaatga cttccttggc    840

ggttttggta cgttcattgc cggcaatggg cgttgtaaca ggaaaagttt tcattaactc    900

ctgccattca atgattaatg catgataggg cctatgaaat gaacttactg gttatagtgg    960

gaatataaat aaagtgaggg atccaacatt actttaaaag tcaccccaac tgtttatatt   1020

tggattctat gcactgtgat cctaaggtta acagcatgaa ttaacatgcg tctttaaagg   1080

actgtaatga aagatcattg catatttatt gaattgttta tatctactgt caagttgttt   1140

tgacatggaa gattttcaag taacattggc agagaggtac agtatgttat ccctatggtg   1200

aaaataaatt aatttgttgt atatagttcc tcaatctctg aagtaaaggt atgagtaata   1260

tagggtatga atggtttaat caaggcttta ttttggaagt aagaaaaatg gcagtgatga   1320

ttaaattgct gcagtccata atttgggctt gttatttgta cattaaagat tttttccaag   1380

taagttacac tctgttaact tcctgctagc catcagcatg agccctactg cctaaacact   1440

atttcattta tttatgtttg gaaaccccgt aaacattttt gtttgcaatc ttgtttcttt   1500

tgttataagt caagtttgaa tgttacaata cttttattga aacttttgtt aagttttttc   1560

ttgtaaattt tctttacttg tgagtatcat cttgtccttt aatcctgtac cctaaaataa   1620

gaaatacatt tttgacagag gcttaatgtt ttaacaaaag agtgtggaca tttttatttt   1680

aaaatttagg caaaagtcac tatcaaatgg ttgcttattt gtctcacaca gccatatagt   1740

ttttcctgga gggttttgtt ttgttgttgt tgaaaagact ttgcttacag ctagatgaaa   1800

ctttctatag aaaaaaaaaa ttgttgaaag gtccagttct cagtaccatg tgagttaatg   1860

atactacaac taagttcttt ttaaaaagtg attaatgtat tttataaatt accttttcac   1920

atatgcaaaa tctgtttcta ctacaatgtt atttttacta atgccttatt gttgcactct   1980

ttttgaaata tcctgcagtg aatatatgaa tcaatttggg cttaaaactg aaagccagtt   2040

ggctgaaagg tttgaaatac gtaccccagt aaaaccattc aatcaataat tggtaaataa   2100

tattttaaaa ttgtttttaa tctgtataga tgacattttg tagctttgta catgttgtta   2160

attaagggca tataatttta cactcaaagt ataattgctg aactcagggg tgggtagact   2220

tcaaaaatat gtctgctata gaaataactt gaaaaaaaaa attaaaaccg tggccagcca   2280

ccaaattgtg gacactgttt atatactgct agttaacaat taccactttt aaaaaattat   2340

aaccgttttt gttctatctt gactagataa attctcacaa tgatctctgt cagttttatt   2400

agttggcctg tttaaccaag acagaaagtc tttgaattac tcatagtttt aaactgcttt   2460

taatatgaaa attgcagctg taaattatgt attttcatat tttgcgtaac tgctctacac   2520

tactgtttga cttgatcttc ttctgggggt tagggagaaa tctgtctcca tattgctggt   2580

tctcttacca aaatgctttt ataaagaaat gaccggtgac atttattcac caaaggaatt   2640

aatatactga gtcaaagatt aacaatgcta tactatagag taataggtca tatatagcct   2700

caattgagtt ttttatgaca atattttaac atacctctct ctctacatat aaataccata   2760

aagtaaacta aaatgacaca gaggaaagta gaggaaaatg aaataatttc ggtacatctt   2820

atggtttaaa gagtagaaaa taagatgaaa tatcctaaaa tataggagca cagacattta   2880

aaattcataa tcaggctaac aacactctct tgaatttagg aatcattgaa aactccttgc   2940

acttagattt aatttatatg ttagttacat tattaaaagt cataaggcat ttatctgagt   3000

cattgctcta cagagagcaa ttaatggctt gtaataataa aaagaatatt tctctgtaat   3060

gcattgttga aagacaacca gaatatcaag aaaatgtata taggaatatg ctacttgcct   3120

cctccctgca tttcctcgtg gggcactatt tgcgacatag gcctacagaa ttagactttc   3180

atacttagaa gataaggtac actcttcttc ttttatttat ttatttattt atttttaggc   3240

cattcttctg gtttgccaaa ttctattaag acagtgatac atttgcttcc ttatttatgc   3300

atgcttagat catgaacatg atgcccttct tttttttttt tttctttggt caagtaggga   3360

ttaatgccat aggtttagag agaaggattg ttttcagttt ttaagagaat tttttaaaaa   3420

tacattttat ggttctctta aggaattaat attcacttct gaaggactta cttgtaatat   3480

ataatttatc attttagcca gcagggaaat aaatcatttt taatccccag aagaaagtgc   3540

tggaaatagc ttctatatag tcagcagttc acctggagaa agatcttaat tccttgttgt   3600

tttgactagg aatatcaata tttggtataa aataactaga atagtttatt accttttccc   3660

tcatgaaatt ttaaatatat gcaaatatat atatcattag attcctgtgg tggataataa   3720

tttcttcaga ttctaaaaca ggtgtctagt gactgcttaa ttgtttccaa gttgcatcaa   3780

agatgaattg gtaaataatg gaaatgagta gtgatatgaa aatggttatg taactacata   3840

ttacttgttt ctggtaatca agtcttattt tttaaaagcc tattgttttt cagaattgag   3900

atatttaaaa cttgttataa cttcttccta aaaatagaag agaagaggag gtactgtgtg   3960

ttacaaaaat ttttttaaat aaagaattca gtgtcactag ttctaaaaaa aaaaaaaaaa   4020

aaca                                                                4024


<210>  540
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  540

Met Ala Ser Met Gln Lys Arg Leu Gln Lys Glu Leu Leu Ala Leu Gln 
1               5                   10                  15


Asn Asp Pro Pro Pro Gly Met Thr Leu Asn Glu Lys Ser Val Gln Asn 
            20                  25                  30


Ser Ile Thr Gln Trp Ile Val Asp Met Glu Gly Ala Pro Gly Thr Leu 
        35                  40                  45


Tyr Glu Gly Glu Lys Phe Gln Leu Leu Phe Lys Phe Ser Ser Arg Tyr 
    50                  55                  60


Pro Phe Asp Ser Pro Gln Val Met Phe Thr Gly Glu Asn Ile Pro Val 
65                  70                  75                  80


His Pro His Val Tyr Ser Asn Gly His Ile Cys Leu Ser Ile Leu Thr 
                85                  90                  95


Glu Asp Trp Ser Pro Ala Leu Ser Val Gln Ser Val Cys Leu Ser Ile 
            100                 105                 110


Ile Ser Met Leu Ser Ser Cys Lys Glu Lys Arg Arg Pro Pro Asp Asn 
        115                 120                 125


Ser Phe Tyr Val Arg Thr Cys Asn Lys Asn Pro Lys Lys Thr Lys Trp 
    130                 135                 140


Trp Tyr His Asp Asp Thr Cys 
145                 150


<210>  541
<211>  668
<212>  DNA
<213>  Homo sapiens

<400>  541
cggggacccg gctgcggtgg ctgcgggact gacgagaaac tactaaagtt cctggggaag     60

caaagtagaa tttcataaga acaaaatgga tggagaggag aaaacctatg gtggctgtga    120

aggacctgat gccatgtatg tcaaattgat atcatctgat ggccatgaat ttattgtaaa    180

aagagaacat gcattaacat caggcacgat aaaagccatg ttgagtggcc caggtcagtt    240

tgctgagaac gaaaccaatg aggtcaattt tagagagata ccttcacatg tgctatcgaa    300

agtatgcatg tattttacgt acaaggttcg ctacactaac agctccaccg agattcctga    360

attcccaatt gcacctgaaa ttgcactgga actgctgatg gctgcgaact tcttagattg    420

ttaaataaaa taaattataa taaactgtta actcttttca gtatttaata cctgtagttc    480

agttagtaac tttttcatat atagcatgtt gcctgtatgc agttgaacta tataaagttc    540

attgcaaagc agattatctt gtttttttgc atagcaatca aagttgaaat ttgtttgcta    600

catcaacaaa ttaaggacat tttcacaaac tgagaaataa acaaatatgc caattaaaaa    660

aaaaaaaa                                                             668


<210>  542
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  542

Met Asp Gly Glu Glu Lys Thr Tyr Gly Gly Cys Glu Gly Pro Asp Ala 
1               5                   10                  15


Met Tyr Val Lys Leu Ile Ser Ser Asp Gly His Glu Phe Ile Val Lys 
            20                  25                  30


Arg Glu His Ala Leu Thr Ser Gly Thr Ile Lys Ala Met Leu Ser Gly 
        35                  40                  45


Pro Gly Gln Phe Ala Glu Asn Glu Thr Asn Glu Val Asn Phe Arg Glu 
    50                  55                  60


Ile Pro Ser His Val Leu Ser Lys Val Cys Met Tyr Phe Thr Tyr Lys 
65                  70                  75                  80


Val Arg Tyr Thr Asn Ser Ser Thr Glu Ile Pro Glu Phe Pro Ile Ala 
                85                  90                  95


Pro Glu Ile Ala Leu Glu Leu Leu Met Ala Ala Asn Phe Leu Asp Cys 
            100                 105                 110


<210>  543
<211>  2030
<212>  DNA
<213>  Homo sapiens

<400>  543
acttgtgcgg cagtcgggtg ggaagccgtg tctcgcagtc gtggactcgt gcagctgggg     60

cgtccgcagc cgctcgtcac ccgcgtgatg ctgtttctgg cgttgggcag cccgtgggcg    120

gtcgaactgc ctctctgcgg aaggaggact gcattgtgtg cggccgccgc gctccgaggt    180

ccccgggcct ctgtctcccg ggcgtcctcc agcagcgggc cttcggggcc ggtagccggc    240

tggagtacgg ggccttcggg agccgcgcgc cttctccggc gtccgggtcg agcgcagatc    300

cctgtttatt gggaaggata tgttcgattc ttaaatacgc catctgacaa atcagaagat    360

ggaaggctaa tttatactgg caatatggcc cgagcagtgt ttggtgtgaa atgtttctct    420

tattctacga gtctgattgg ccttacattt ctgccataca tttttacaca aaataatgct    480

atttctgaaa gtgtgcctct gcctattcaa atcatattct atggcatcat gggaagcttt    540

acggtgatca ccccagtgct gcttcacttt attacaaaag gctatgtcat tcgattgtac    600

catgaggcca caacagacac ttataaagcc attacctaca atgctatgct tgcagaaacg    660

agtacagtgt ttcaccagaa tgatgtgaag attccagatg ctaaacatgt atttaccaca    720

ttttatgcta aaacaaaatc actgttagtt aatccagtgc tctttccaaa ccgtgaagac    780

tatatccatc taatgggtta tgacaaagaa gaatttattt tgtatatgga agaaaccagt    840

gaagagaaac ggcataaaga tgacaaatga gcctatttgt tagtgttcgt gctcaaatgt    900

gatttacgtt ttaatgtata ataataaaat tgccttttgc attccgttag tgactgattg    960

ttaaaaataa tttgaaatta tcaaagcttt taatttccag agaatgatgt ttgtttataa   1020

taaaacaagc tatgtttgaa aaccaaaatg tagtatctac cattcgtgtt ttagaaaggt   1080

atgtgaataa atatgttcat gctagtataa gagttctgtg ttactgtggt tgactctaaa   1140

ctggggatct gatgtcagta gcaaatggga gagttgcttt attctttgtg tatggatttt   1200

tctaagtgta taaatatttt ccgacattaa aagacatttt ctctttgagg aagacacagt   1260

cataggtggt gcggagctgt ggtccacctg ctcctgctcc tgactcactg ctctttgctg   1320

ttgcctgagg accaagtctg tcaggaagct ggctaggaag ccttgcagca gccatggctt   1380

ttaaacatac cagaaaaaca cccgtggagt cagaggtggc aattcaccga attcatatca   1440

ctctaacgag ttgcaacgta aaatccctgg ataaggtgtg tgctgacttg atctgaggag   1500

caaaggaaaa gaatcagtga aaggaccagt ttgaatgcct accaagactt tgagaatcac   1560

tacaagaaaa acttacggtg aaggttctaa ggcatgggat cgtttccaga tgagaatcca   1620

caagcgactc attgacttgc gcagtcctca gatagttaag cagattactt ccatcagtat   1680

tgagccagga gttgagatgg aagtcaccat tgcaaatgct taagtcaact gttttcataa   1740

attgattacc agttgttaaa aaattttcaa aaaaccgcaa aatttcaaga aattcacaaa   1800

ttatgggagc agttttaagt cttctttggt tcagaacaca ggtttttgcc taacccctgg   1860

catgattgcc cataagaaca tacatgtaca gttgaactgg tggttagcta tacgggaaat   1920

ggtaagtagt gttgtcttca gtatcttaat ttgtttctgc aactgtgcac tcctcccttg   1980

gtggcaccct atgggtgtag gaaaaccact gttattaaac aggtgaaaaa              2030


<210>  544
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  544

Met Leu Phe Leu Ala Leu Gly Ser Pro Trp Ala Val Glu Leu Pro Leu 
1               5                   10                  15


Cys Gly Arg Arg Thr Ala Leu Cys Ala Ala Ala Ala Leu Arg Gly Pro 
            20                  25                  30


Arg Ala Ser Val Ser Arg Ala Ser Ser Ser Ser Gly Pro Ser Gly Pro 
        35                  40                  45


Val Ala Gly Trp Ser Thr Gly Pro Ser Gly Ala Ala Arg Leu Leu Arg 
    50                  55                  60


Arg Pro Gly Arg Ala Gln Ile Pro Val Tyr Trp Glu Gly Tyr Val Arg 
65                  70                  75                  80


Phe Leu Asn Thr Pro Ser Asp Lys Ser Glu Asp Gly Arg Leu Ile Tyr 
                85                  90                  95


Thr Gly Asn Met Ala Arg Ala Val Phe Gly Val Lys Cys Phe Ser Tyr 
            100                 105                 110


Ser Thr Ser Leu Ile Gly Leu Thr Phe Leu Pro Tyr Ile Phe Thr Gln 
        115                 120                 125


Asn Asn Ala Ile Ser Glu Ser Val Pro Leu Pro Ile Gln Ile Ile Phe 
    130                 135                 140


Tyr Gly Ile Met Gly Ser Phe Thr Val Ile Thr Pro Val Leu Leu His 
145                 150                 155                 160


Phe Ile Thr Lys Gly Tyr Val Ile Arg Leu Tyr His Glu Ala Thr Thr 
                165                 170                 175


Asp Thr Tyr Lys Ala Ile Thr Tyr Asn Ala Met Leu Ala Glu Thr Ser 
            180                 185                 190


Thr Val Phe His Gln Asn Asp Val Lys Ile Pro Asp Ala Lys His Val 
        195                 200                 205


Phe Thr Thr Phe Tyr Ala Lys Thr Lys Ser Leu Leu Val Asn Pro Val 
    210                 215                 220


Leu Phe Pro Asn Arg Glu Asp Tyr Ile His Leu Met Gly Tyr Asp Lys 
225                 230                 235                 240


Glu Glu Phe Ile Leu Tyr Met Glu Glu Thr Ser Glu Glu Lys Arg His 
                245                 250                 255


Lys Asp Asp Lys 
            260


<210>  545
<211>  587
<212>  DNA
<213>  Homo sapiens

<400>  545
taaatctttt ctgcttactg aaaaggaaga gtctgatgat tagttactga tcctctttgc     60

atttgtaaag ctttggagat attgaatcat gttaccattt ctgttttttt ccaccctgtt    120

ttcttccata tttactgaag ctcagaagca gtattgggtc tgcaactcat ccgatgcaag    180

tatttcatac acctactgtg ataaaatgca atacccaatt tcaattaatg ttaacccctg    240

tatagaattg aaaggatcca aaggattatt gcacattttc tacattccaa ggagagattt    300

aaagcaatta tatttcaatc tctatataac tgtcaacacc atgaatcttc caaagcgcaa    360

agaagttatt tgccgaggat ctgatgacga ttactctttt tgcagagctc tgaagggaga    420

gactgtgaat acaacaatat cattctcctt caagggaata aaattttcta agggaaaata    480

caaatgtgtt gttgaagcta tttctgggag cccagaagaa atgctctttt gcttggagtt    540

tgtcatccta caccaaccta attcaaatta gaataaattg agtattt                  587


<210>  546
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  546

Met Leu Pro Phe Leu Phe Phe Ser Thr Leu Phe Ser Ser Ile Phe Thr 
1               5                   10                  15


Glu Ala Gln Lys Gln Tyr Trp Val Cys Asn Ser Ser Asp Ala Ser Ile 
            20                  25                  30


Ser Tyr Thr Tyr Cys Asp Lys Met Gln Tyr Pro Ile Ser Ile Asn Val 
        35                  40                  45


Asn Pro Cys Ile Glu Leu Lys Gly Ser Lys Gly Leu Leu His Ile Phe 
    50                  55                  60


Tyr Ile Pro Arg Arg Asp Leu Lys Gln Leu Tyr Phe Asn Leu Tyr Ile 
65                  70                  75                  80


Thr Val Asn Thr Met Asn Leu Pro Lys Arg Lys Glu Val Ile Cys Arg 
                85                  90                  95


Gly Ser Asp Asp Asp Tyr Ser Phe Cys Arg Ala Leu Lys Gly Glu Thr 
            100                 105                 110


Val Asn Thr Thr Ile Ser Phe Ser Phe Lys Gly Ile Lys Phe Ser Lys 
        115                 120                 125


Gly Lys Tyr Lys Cys Val Val Glu Ala Ile Ser Gly Ser Pro Glu Glu 
    130                 135                 140


Met Leu Phe Cys Leu Glu Phe Val Ile Leu His Gln Pro Asn Ser Asn 
145                 150                 155                 160


<210>  547
<211>  724
<212>  DNA
<213>  Homo sapiens

<400>  547
caaaggtcag aggtaaagaa gtcatggcgg cgctgtgtcg gacccgtgct gtggctgccg     60

agagccattt tctgcgagtg tttctcttct tcaggccctt tcggggtgta ggcactgaga    120

gtggatccga aagtggtagt tccaatgcca aggagcctaa gacgcgcgca ggcggtttcg    180

cgagcgcgtt ggagcggcac tcggagcttc tacagaaggt ggagccccta cagaagggtt    240

ctccaaaaaa tgtggaatcc tttgcatcta tgctgagaca ttctcctctt acacagatgg    300

gacctgcaaa ggataaactg gtcattggac ggatctttca tattgtggag aatgatctgt    360

acatagattt tggtggaaag tttcattgtg tatgtagaag accagaagtg gatggagaga    420

aataccagaa aggaaccagg gtccggttgc ggctattaga tcttgaactt acgtctaggt    480

tcctgggagc aacaacagat acaactgtac tagaggctaa tgcagttctc ttgggaatcc    540

aggagagtaa agactcaaga tcgaaagaag aacatcatga aaaataaatg aactttgctt    600

agtggattga ctcctttgct gaagtcagtt attcatcaag aatgcaatta gactaattgt    660

gaataaatga ttgaatgaag atataataaa taaaagctat aattataaaa aaaaaaaaaa    720

aaaa                                                                 724


<210>  548
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  548

Met Ala Ala Leu Cys Arg Thr Arg Ala Val Ala Ala Glu Ser His Phe 
1               5                   10                  15


Leu Arg Val Phe Leu Phe Phe Arg Pro Phe Arg Gly Val Gly Thr Glu 
            20                  25                  30


Ser Gly Ser Glu Ser Gly Ser Ser Asn Ala Lys Glu Pro Lys Thr Arg 
        35                  40                  45


Ala Gly Gly Phe Ala Ser Ala Leu Glu Arg His Ser Glu Leu Leu Gln 
    50                  55                  60


Lys Val Glu Pro Leu Gln Lys Gly Ser Pro Lys Asn Val Glu Ser Phe 
65                  70                  75                  80


Ala Ser Met Leu Arg His Ser Pro Leu Thr Gln Met Gly Pro Ala Lys 
                85                  90                  95


Asp Lys Leu Val Ile Gly Arg Ile Phe His Ile Val Glu Asn Asp Leu 
            100                 105                 110


Tyr Ile Asp Phe Gly Gly Lys Phe His Cys Val Cys Arg Arg Pro Glu 
        115                 120                 125


Val Asp Gly Glu Lys Tyr Gln Lys Gly Thr Arg Val Arg Leu Arg Leu 
    130                 135                 140


Leu Asp Leu Glu Leu Thr Ser Arg Phe Leu Gly Ala Thr Thr Asp Thr 
145                 150                 155                 160


Thr Val Leu Glu Ala Asn Ala Val Leu Leu Gly Ile Gln Glu Ser Lys 
                165                 170                 175


Asp Ser Arg Ser Lys Glu Glu His His Glu Lys 
            180                 185


<210>  549
<211>  4250
<212>  DNA
<213>  Homo sapiens

<400>  549
gcccttcttt gttgactgag gaaagctcgc tccctgccca ggtttttcat tgttgatcga     60

aattaacacc aggtggtgaa tagagcccct cctaaggttg ctcaggataa atcatttatt    120

aaataggtct gcttatcagg aggggcgtga aggctcccaa aaggaaatgc tggcacctgg    180

gcccagaagc cagggcctct aactcctggg gttgatttct tcagtgaagt tgcaccctac    240

aaagggaata tggccaaagc ggcactcaac tgaaggctga tatcaggcga ttagacagcc    300

atgcattctg cgtttgtctg gaatggattg tagagagatg gacttatatg aggactacca    360

gtccccgttt gattttgatg caggagtgaa caaaagctat ctctacttgt ctcctagtgg    420

aaattcatct ccacccggat cacctactct tcagaaattt ggtctgctga gaacagaccc    480

agtccctgag gaaggagaag atgttgctgc cacgatcagt gccacagaga ccctctcgga    540

agaggagcag gaagagctaa gaagagaact tgcaaaggta gaagaagaaa tccagactct    600

gtctcaagtg ttagcagcaa aagagaagca tctagcagag atcaagcgga aacttggaat    660

caattctcta caggaactaa aacagaacat tgccaaaggg tggcaagacg tgacagcaac    720

atctgcttac aagaagacat ctgaaacctt atcccaggct ggacagaagg cctcagctgc    780

tttttcgtct gttggctcag tcatcaccaa aaagctggaa gatgtaaaaa actccccaac    840

ttttaaatca tttgaagaaa aggtcgaaaa cttaaagtct aaagtagggg gaaccaagcc    900

tgctggtggt gattttggag aagtcttgaa ttcggctgca aatgctagtg ccaccaccac    960

ggagcctctt ccagaaaaga cacaggagag cctgtgagat tcctaccttt gttctgctac   1020

ccactgccag atgctgcaag cgaggtccaa gcacatcttg tcaacatgca ttgccatgaa   1080

tttctaccag atgtgctttt atttagcttt acatattcct ttgaccaaat agtttgtggg   1140

ttaaacaaaa tgaaaatatc ttcacctcta ttcttgggaa acacccttta gtgtacattt   1200

atgttccttt atttaggaaa caccattata aaaacactta tagtaaatgg ggacattcac   1260

tataatgatc taagaagcta cagattgtca tagttgtttt cctgctttac aaaattgctc   1320

cagatctgga atgccagttt gacctttgtc ttctataata tttccttttt ttcccctctt   1380

tgaatctctg tatatttgat tcttaactaa aattgttctc ttaaatattc tgaatcctgg   1440

taattaaaag tttgggtgta ttttctttac ctccaaggaa agaactacta gctacaaaaa   1500

atattttgga ataagcattg ttttggtata aggtacatat tttggttgaa gacaccagac   1560

tgaagtaaac agctgtgcat ccaatttatt atagttttgt aagtaacaat atgtaatcaa   1620

acttctaggt gacttgagag tggaacctcc tatatcatta tttagcaccg tttgtgacag   1680

taaccatttc agtgtattgt ttattatacc acttatatca acttattttt caccaggtta   1740

aaattttaat ttctacaaaa taacattctg aatcaagcac actgtatgtt cagtaggttg   1800

aactatgaac actgtcatca atgttcagtt caaaagcctg aaagtttaga tctagaagct   1860

ggtaaaaatg acaatatcaa tcacattagg ggaaccattg ttgtcttcac ttaatccatt   1920

tagcactatt taaaataagc acaccaagtt atatgactaa tataacttga aaatttttta   1980

tactgagggg ttggtgataa ctcttgagga tgtaatgcat taataaaaat caactcatca   2040

ttttctactt gttttcaatg tgttggaaac tgtaaaatga tactgtagaa cctgtctcct   2100

actttgaaaa ctgaatgtca gggctgagtg aatcaaagtg tctagacata tttgcataga   2160

ggccaaggta ttctattcta ataactgctt actcaacact accacctttt ccttatactg   2220

tatatgatta tggcctacaa tgttgtattt gttatttatt aaattgtgat tgttttatta   2280

ttgtttatgc caaatgttaa ctgccaagct tggagtgacc taaagcattt tttaaaagca   2340

tggctagatt tacttcagta taaattatct tatgaaaacc aaattttaaa agccacaggt   2400

gttgattgtt ataaaataac atgctgccat tcttgattgc tagagttttt gttagtactt   2460

tggatgcaat taaaactatg tgctatcaca tgtgaaaagc ttaataaatt ccatctatca   2520

gtagtatagg tctcaatatt tattatgaga ccagtggtct ggaaacagct tgttgtaccg   2580

aatcaactgg agtctatgct taaaaaaaaa aaattttttt ttaaccatcc ttaaattatt   2640

gcttaatggt atcatattaa catattctaa ataagggctt taaggcacag gctgttgaag   2700

cattttctca gaggagtgga tctgtagaag tctgtctttc tatagaaata ttgtgcttac   2760

tcaagtgtta aattattttt tctatgaact agtctacttc ttaaaattca aacatattct   2820

tttgatcaca ttgtttcttg agcatcctgc cctgctacta acttttcaac aaggcaaaat   2880

ggagtaaagt ggcaatttct ttagatgagt gaaataccct caagtctctt ttctgcccaa   2940

aaagggaaaa gtgatagaaa tgggggtggc aagtggggtg agtggatgaa ggtgggtatt   3000

gggggtggct gtgaaagaaa ataatggaga atcacttttc tagacatcta cctatactta   3060

atctaagaaa caaagtaatc tactgtaaag tactctgccc cttgaaagaa gtattaaaaa   3120

gagtgaggat ggatttagaa aaaaacatga atttagaaat attcaaaatg gtttttgtgg   3180

cagattcaat attatgaatt cacagatatt taaagaatga gaaacatagt aattagtaga   3240

aatgccagaa acagttcctg gttcctcttg tgtttgacac taagaaaata gcaagagtgt   3300

gaaatctcag atacttatga aatctcacag atgtaaggac tcaagtgtag aagaaaatat   3360

ccccttctta caaaaagaaa tgtcaattta tggagtttgt gggaaatagg gcaagaattc   3420

ttatgcttat gagagccaag tagtcagtgg aagagagtag agctcaaaac tggattatca   3480

ccttagcaac ttagaatagt ttgaaataga aaaaaagtat ttaatttgga tctggatctg   3540

ttaagatatg cacagtctat tttttgtata gtattggaaa ataaaaatgc tataatttgg   3600

gtatgggttc ttttgtatac attacctgcc cattgaggaa aggggcaagt ccattatgca   3660

acttctctcc aaacccttca tattctggat atgatactta aagagccatg agcagctaca   3720

ttctgcctat cagaaggcat ttattaaatg actgcttgct gaagatgtgt ccaaagagat   3780

cctacattaa ggtcatttgt cagaatgatg tttgtgtttg tttagagttg gctgacctcc   3840

aactcctggg gtcaaggaat cctactgcct tagcttccca aatagctagg actataggca   3900

tgcacccggc catgtgtttt atttatagct cttaaagccc agatgaagaa atcacatttt   3960

tgcccatagt gaagaaacat ttggccattg attagtcctt attttcagtg actgtcctgt   4020

tttcattaga ttagagagac cctgtgtggg ccacagttaa tataaaccat tatcactttt   4080

aagtaaacct gcacatctta gatttcataa tttccttatt gttctgactc aaaatgaact   4140

aagagctttt cactttttgt ttgtaagttc tcagagagtc gggtctgcaa gtgcttttgc   4200

ctgccaggat tttgtactca aataaatgct atttggcaac taaaaaaaaa              4250


<210>  550
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  550

Met Asp Cys Arg Glu Met Asp Leu Tyr Glu Asp Tyr Gln Ser Pro Phe 
1               5                   10                  15


Asp Phe Asp Ala Gly Val Asn Lys Ser Tyr Leu Tyr Leu Ser Pro Ser 
            20                  25                  30


Gly Asn Ser Ser Pro Pro Gly Ser Pro Thr Leu Gln Lys Phe Gly Leu 
        35                  40                  45


Leu Arg Thr Asp Pro Val Pro Glu Glu Gly Glu Asp Val Ala Ala Thr 
    50                  55                  60


Ile Ser Ala Thr Glu Thr Leu Ser Glu Glu Glu Gln Glu Glu Leu Arg 
65                  70                  75                  80


Arg Glu Leu Ala Lys Val Glu Glu Glu Ile Gln Thr Leu Ser Gln Val 
                85                  90                  95


Leu Ala Ala Lys Glu Lys His Leu Ala Glu Ile Lys Arg Lys Leu Gly 
            100                 105                 110


Ile Asn Ser Leu Gln Glu Leu Lys Gln Asn Ile Ala Lys Gly Trp Gln 
        115                 120                 125


Asp Val Thr Ala Thr Ser Ala Tyr Lys Lys Thr Ser Glu Thr Leu Ser 
    130                 135                 140


Gln Ala Gly Gln Lys Ala Ser Ala Ala Phe Ser Ser Val Gly Ser Val 
145                 150                 155                 160


Ile Thr Lys Lys Leu Glu Asp Val Lys Asn Ser Pro Thr Phe Lys Ser 
                165                 170                 175


Phe Glu Glu Lys Val Glu Asn Leu Lys Ser Lys Val Gly Gly Thr Lys 
            180                 185                 190


Pro Ala Gly Gly Asp Phe Gly Glu Val Leu Asn Ser Ala Ala Asn Ala 
        195                 200                 205


Ser Ala Thr Thr Thr Glu Pro Leu Pro Glu Lys Thr Gln Glu Ser Leu 
    210                 215                 220


<210>  551
<211>  4035
<212>  DNA
<213>  Homo sapiens

<400>  551
gggcggcgcc gccgcgcccg acgcctctgg gggtggggac ttcgcgggag tcgccggcgg     60

aggcgaggag gagctctgcg cggcgcggcg ggcgatccga gccgggacgg gctgcaggcg    120

ggggtgctgc agaggacacg aggcggcggg ctggagacat ggaccgcggc gagcaaggtc    180

tgctgagaac agacccagtc cctgaggaag gagaagatgt tgctgccacg atcagtgcca    240

cagagaccct ctcggaagag gagcaggaag agctaagaag agaacttgca aaggtagaag    300

aagaaatcca gactctgtct caagtgttag cagcaaaaga gaagcatcta gcagagatca    360

agcggaaact tggaatcaat tctctacagg aactaaaaca gaacattgcc aaagggtggc    420

aagacgtgac agcaacatct gcttacaaga agacatctga aaccttatcc caggctggac    480

agaaggcctc agctgctttt tcgtctgttg gctcagtcat caccaaaaag ctggaagatg    540

taaaattgca agccttttca cattccttta gtatacgttc cattcagcat tcaattagca    600

tgcctgctat gagaaactcc ccaactttta aatcatttga agaaaaggtc gaaaacttaa    660

agtctaaagt agggggaacc aagcctgctg gtggtgattt tggagaagtc ttgaattcgg    720

ctgcaaatgc tagtgccacc accacggagc ctcttccaga aaagacacag gagagcctgt    780

gagattccta cctttgttct gctacccact gccagatgct gcaagcgagg tccaagcaca    840

tcttgtcaac atgcattgcc atgaatttct accagatgtg cttttattta gctttacata    900

ttcctttgac caaatagttt gtgggttaaa caaaatgaaa atatcttcac ctctattctt    960

gggaaacacc ctttagtgta catttatgtt cctttattta ggaaacacca ttataaaaac   1020

acttatagta aatggggaca ttcactataa tgatctaaga agctacagat tgtcatagtt   1080

gttttcctgc tttacaaaat tgctccagat ctggaatgcc agtttgacct ttgtcttcta   1140

taatatttcc tttttttccc ctctttgaat ctctgtatat ttgattctta actaaaattg   1200

ttctcttaaa tattctgaat cctggtaatt aaaagtttgg gtgtattttc tttacctcca   1260

aggaaagaac tactagctac aaaaaatatt ttggaataag cattgttttg gtataaggta   1320

catattttgg ttgaagacac cagactgaag taaacagctg tgcatccaat ttattatagt   1380

tttgtaagta acaatatgta atcaaacttc taggtgactt gagagtggaa cctcctatat   1440

cattatttag caccgtttgt gacagtaacc atttcagtgt attgtttatt ataccactta   1500

tatcaactta tttttcacca ggttaaaatt ttaatttcta caaaataaca ttctgaatca   1560

agcacactgt atgttcagta ggttgaacta tgaacactgt catcaatgtt cagttcaaaa   1620

gcctgaaagt ttagatctag aagctggtaa aaatgacaat atcaatcaca ttaggggaac   1680

cattgttgtc ttcacttaat ccatttagca ctatttaaaa taagcacacc aagttatatg   1740

actaatataa cttgaaaatt ttttatactg aggggttggt gataactctt gaggatgtaa   1800

tgcattaata aaaatcaact catcattttc tacttgtttt caatgtgttg gaaactgtaa   1860

aatgatactg tagaacctgt ctcctacttt gaaaactgaa tgtcagggct gagtgaatca   1920

aagtgtctag acatatttgc atagaggcca aggtattcta ttctaataac tgcttactca   1980

acactaccac cttttcctta tactgtatat gattatggcc tacaatgttg tatttgttat   2040

ttattaaatt gtgattgttt tattattgtt tatgccaaat gttaactgcc aagcttggag   2100

tgacctaaag cattttttaa aagcatggct agatttactt cagtataaat tatcttatga   2160

aaaccaaatt ttaaaagcca caggtgttga ttgttataaa ataacatgct gccattcttg   2220

attgctagag tttttgttag tactttggat gcaattaaaa ctatgtgcta tcacatgtga   2280

aaagcttaat aaattccatc tatcagtagt ataggtctca atatttatta tgagaccagt   2340

ggtctggaaa cagcttgttg taccgaatca actggagtct atgcttaaaa aaaaaaaatt   2400

tttttttaac catccttaaa ttattgctta atggtatcat attaacatat tctaaataag   2460

ggctttaagg cacaggctgt tgaagcattt tctcagagga gtggatctgt agaagtctgt   2520

ctttctatag aaatattgtg cttactcaag tgttaaatta ttttttctat gaactagtct   2580

acttcttaaa attcaaacat attcttttga tcacattgtt tcttgagcat cctgccctgc   2640

tactaacttt tcaacaaggc aaaatggagt aaagtggcaa tttctttaga tgagtgaaat   2700

accctcaagt ctcttttctg cccaaaaagg gaaaagtgat agaaatgggg gtggcaagtg   2760

gggtgagtgg atgaaggtgg gtattggggg tggctgtgaa agaaaataat ggagaatcac   2820

ttttctagac atctacctat acttaatcta agaaacaaag taatctactg taaagtactc   2880

tgccccttga aagaagtatt aaaaagagtg aggatggatt tagaaaaaaa catgaattta   2940

gaaatattca aaatggtttt tgtggcagat tcaatattat gaattcacag atatttaaag   3000

aatgagaaac atagtaatta gtagaaatgc cagaaacagt tcctggttcc tcttgtgttt   3060

gacactaaga aaatagcaag agtgtgaaat ctcagatact tatgaaatct cacagatgta   3120

aggactcaag tgtagaagaa aatatcccct tcttacaaaa agaaatgtca atttatggag   3180

tttgtgggaa atagggcaag aattcttatg cttatgagag ccaagtagtc agtggaagag   3240

agtagagctc aaaactggat tatcacctta gcaacttaga atagtttgaa atagaaaaaa   3300

agtatttaat ttggatctgg atctgttaag atatgcacag tctatttttt gtatagtatt   3360

ggaaaataaa aatgctataa tttgggtatg ggttcttttg tatacattac ctgcccattg   3420

aggaaagggg caagtccatt atgcaacttc tctccaaacc cttcatattc tggatatgat   3480

acttaaagag ccatgagcag ctacattctg cctatcagaa ggcatttatt aaatgactgc   3540

ttgctgaaga tgtgtccaaa gagatcctac attaaggtca tttgtcagaa tgatgtttgt   3600

gtttgtttag agttggctga cctccaactc ctggggtcaa ggaatcctac tgccttagct   3660

tcccaaatag ctaggactat aggcatgcac ccggccatgt gttttattta tagctcttaa   3720

agcccagatg aagaaatcac atttttgccc atagtgaaga aacatttggc cattgattag   3780

tccttatttt cagtgactgt cctgttttca ttagattaga gagaccctgt gtgggccaca   3840

gttaatataa accattatca cttttaagta aacctgcaca tcttagattt cataatttcc   3900

ttattgttct gactcaaaat gaactaagag cttttcactt tttgtttgta agttctcaga   3960

gagtcgggtc tgcaagtgct tttgcctgcc aggattttgt actcaaataa atgctatttg   4020

gcaactaaaa aaaaa                                                    4035


<210>  552
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  552

Met Asp Arg Gly Glu Gln Gly Leu Leu Arg Thr Asp Pro Val Pro Glu 
1               5                   10                  15


Glu Gly Glu Asp Val Ala Ala Thr Ile Ser Ala Thr Glu Thr Leu Ser 
            20                  25                  30


Glu Glu Glu Gln Glu Glu Leu Arg Arg Glu Leu Ala Lys Val Glu Glu 
        35                  40                  45


Glu Ile Gln Thr Leu Ser Gln Val Leu Ala Ala Lys Glu Lys His Leu 
    50                  55                  60


Ala Glu Ile Lys Arg Lys Leu Gly Ile Asn Ser Leu Gln Glu Leu Lys 
65                  70                  75                  80


Gln Asn Ile Ala Lys Gly Trp Gln Asp Val Thr Ala Thr Ser Ala Tyr 
                85                  90                  95


Lys Lys Thr Ser Glu Thr Leu Ser Gln Ala Gly Gln Lys Ala Ser Ala 
            100                 105                 110


Ala Phe Ser Ser Val Gly Ser Val Ile Thr Lys Lys Leu Glu Asp Val 
        115                 120                 125


Lys Leu Gln Ala Phe Ser His Ser Phe Ser Ile Arg Ser Ile Gln His 
    130                 135                 140


Ser Ile Ser Met Pro Ala Met Arg Asn Ser Pro Thr Phe Lys Ser Phe 
145                 150                 155                 160


Glu Glu Lys Val Glu Asn Leu Lys Ser Lys Val Gly Gly Thr Lys Pro 
                165                 170                 175


Ala Gly Gly Asp Phe Gly Glu Val Leu Asn Ser Ala Ala Asn Ala Ser 
            180                 185                 190


Ala Thr Thr Thr Glu Pro Leu Pro Glu Lys Thr Gln Glu Ser Leu 
        195                 200                 205


<210>  553
<211>  3966
<212>  DNA
<213>  Homo sapiens

<400>  553
gggcggcgcc gccgcgcccg acgcctctgg gggtggggac ttcgcgggag tcgccggcgg     60

aggcgaggag gagctctgcg cggcgcggcg ggcgatccga gccgggacgg gctgcaggcg    120

ggggtgctgc agaggacacg aggcggcggg ctggagacat ggaccgcggc gagcaaggtc    180

tgctgagaac agacccagtc cctgaggaag gagaagatgt tgctgccacg atcagtgcca    240

cagagaccct ctcggaagag gagcaggaag agctaagaag agaacttgca aaggtagaag    300

aagaaatcca gactctgtct caagtgttag cagcaaaaga gaagcatcta gcagagatca    360

agcggaaact tggaatcaat tctctacagg aactaaaaca gaacattgcc aaagggtggc    420

aagacgtgac agcaacatct gcttacaaga agacatctga aaccttatcc caggctggac    480

agaaggcctc agctgctttt tcgtctgttg gctcagtcat caccaaaaag ctggaagatg    540

taaaaaactc cccaactttt aaatcatttg aagaaaaggt cgaaaactta aagtctaaag    600

tagggggaac caagcctgct ggtggtgatt ttggagaagt cttgaattcg gctgcaaatg    660

ctagtgccac caccacggag cctcttccag aaaagacaca ggagagcctg tgagattcct    720

acctttgttc tgctacccac tgccagatgc tgcaagcgag gtccaagcac atcttgtcaa    780

catgcattgc catgaatttc taccagatgt gcttttattt agctttacat attcctttga    840

ccaaatagtt tgtgggttaa acaaaatgaa aatatcttca cctctattct tgggaaacac    900

cctttagtgt acatttatgt tcctttattt aggaaacacc attataaaaa cacttatagt    960

aaatggggac attcactata atgatctaag aagctacaga ttgtcatagt tgttttcctg   1020

ctttacaaaa ttgctccaga tctggaatgc cagtttgacc tttgtcttct ataatatttc   1080

ctttttttcc cctctttgaa tctctgtata tttgattctt aactaaaatt gttctcttaa   1140

atattctgaa tcctggtaat taaaagtttg ggtgtatttt ctttacctcc aaggaaagaa   1200

ctactagcta caaaaaatat tttggaataa gcattgtttt ggtataaggt acatattttg   1260

gttgaagaca ccagactgaa gtaaacagct gtgcatccaa tttattatag ttttgtaagt   1320

aacaatatgt aatcaaactt ctaggtgact tgagagtgga acctcctata tcattattta   1380

gcaccgtttg tgacagtaac catttcagtg tattgtttat tataccactt atatcaactt   1440

atttttcacc aggttaaaat tttaatttct acaaaataac attctgaatc aagcacactg   1500

tatgttcagt aggttgaact atgaacactg tcatcaatgt tcagttcaaa agcctgaaag   1560

tttagatcta gaagctggta aaaatgacaa tatcaatcac attaggggaa ccattgttgt   1620

cttcacttaa tccatttagc actatttaaa ataagcacac caagttatat gactaatata   1680

acttgaaaat tttttatact gaggggttgg tgataactct tgaggatgta atgcattaat   1740

aaaaatcaac tcatcatttt ctacttgttt tcaatgtgtt ggaaactgta aaatgatact   1800

gtagaacctg tctcctactt tgaaaactga atgtcagggc tgagtgaatc aaagtgtcta   1860

gacatatttg catagaggcc aaggtattct attctaataa ctgcttactc aacactacca   1920

ccttttcctt atactgtata tgattatggc ctacaatgtt gtatttgtta tttattaaat   1980

tgtgattgtt ttattattgt ttatgccaaa tgttaactgc caagcttgga gtgacctaaa   2040

gcatttttta aaagcatggc tagatttact tcagtataaa ttatcttatg aaaaccaaat   2100

tttaaaagcc acaggtgttg attgttataa aataacatgc tgccattctt gattgctaga   2160

gtttttgtta gtactttgga tgcaattaaa actatgtgct atcacatgtg aaaagcttaa   2220

taaattccat ctatcagtag tataggtctc aatatttatt atgagaccag tggtctggaa   2280

acagcttgtt gtaccgaatc aactggagtc tatgcttaaa aaaaaaaaat ttttttttaa   2340

ccatccttaa attattgctt aatggtatca tattaacata ttctaaataa gggctttaag   2400

gcacaggctg ttgaagcatt ttctcagagg agtggatctg tagaagtctg tctttctata   2460

gaaatattgt gcttactcaa gtgttaaatt attttttcta tgaactagtc tacttcttaa   2520

aattcaaaca tattcttttg atcacattgt ttcttgagca tcctgccctg ctactaactt   2580

ttcaacaagg caaaatggag taaagtggca atttctttag atgagtgaaa taccctcaag   2640

tctcttttct gcccaaaaag ggaaaagtga tagaaatggg ggtggcaagt ggggtgagtg   2700

gatgaaggtg ggtattgggg gtggctgtga aagaaaataa tggagaatca cttttctaga   2760

catctaccta tacttaatct aagaaacaaa gtaatctact gtaaagtact ctgccccttg   2820

aaagaagtat taaaaagagt gaggatggat ttagaaaaaa acatgaattt agaaatattc   2880

aaaatggttt ttgtggcaga ttcaatatta tgaattcaca gatatttaaa gaatgagaaa   2940

catagtaatt agtagaaatg ccagaaacag ttcctggttc ctcttgtgtt tgacactaag   3000

aaaatagcaa gagtgtgaaa tctcagatac ttatgaaatc tcacagatgt aaggactcaa   3060

gtgtagaaga aaatatcccc ttcttacaaa aagaaatgtc aatttatgga gtttgtggga   3120

aatagggcaa gaattcttat gcttatgaga gccaagtagt cagtggaaga gagtagagct   3180

caaaactgga ttatcacctt agcaacttag aatagtttga aatagaaaaa aagtatttaa   3240

tttggatctg gatctgttaa gatatgcaca gtctattttt tgtatagtat tggaaaataa   3300

aaatgctata atttgggtat gggttctttt gtatacatta cctgcccatt gaggaaaggg   3360

gcaagtccat tatgcaactt ctctccaaac ccttcatatt ctggatatga tacttaaaga   3420

gccatgagca gctacattct gcctatcaga aggcatttat taaatgactg cttgctgaag   3480

atgtgtccaa agagatccta cattaaggtc atttgtcaga atgatgtttg tgtttgttta   3540

gagttggctg acctccaact cctggggtca aggaatccta ctgccttagc ttcccaaata   3600

gctaggacta taggcatgca cccggccatg tgttttattt atagctctta aagcccagat   3660

gaagaaatca catttttgcc catagtgaag aaacatttgg ccattgatta gtccttattt   3720

tcagtgactg tcctgttttc attagattag agagaccctg tgtgggccac agttaatata   3780

aaccattatc acttttaagt aaacctgcac atcttagatt tcataatttc cttattgttc   3840

tgactcaaaa tgaactaaga gcttttcact ttttgtttgt aagttctcag agagtcgggt   3900

ctgcaagtgc ttttgcctgc caggattttg tactcaaata aatgctattt ggcaactaaa   3960

aaaaaa                                                              3966


<210>  554
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  554

Met Asp Arg Gly Glu Gln Gly Leu Leu Arg Thr Asp Pro Val Pro Glu 
1               5                   10                  15


Glu Gly Glu Asp Val Ala Ala Thr Ile Ser Ala Thr Glu Thr Leu Ser 
            20                  25                  30


Glu Glu Glu Gln Glu Glu Leu Arg Arg Glu Leu Ala Lys Val Glu Glu 
        35                  40                  45


Glu Ile Gln Thr Leu Ser Gln Val Leu Ala Ala Lys Glu Lys His Leu 
    50                  55                  60


Ala Glu Ile Lys Arg Lys Leu Gly Ile Asn Ser Leu Gln Glu Leu Lys 
65                  70                  75                  80


Gln Asn Ile Ala Lys Gly Trp Gln Asp Val Thr Ala Thr Ser Ala Tyr 
                85                  90                  95


Lys Lys Thr Ser Glu Thr Leu Ser Gln Ala Gly Gln Lys Ala Ser Ala 
            100                 105                 110


Ala Phe Ser Ser Val Gly Ser Val Ile Thr Lys Lys Leu Glu Asp Val 
        115                 120                 125


Lys Asn Ser Pro Thr Phe Lys Ser Phe Glu Glu Lys Val Glu Asn Leu 
    130                 135                 140


Lys Ser Lys Val Gly Gly Thr Lys Pro Ala Gly Gly Asp Phe Gly Glu 
145                 150                 155                 160


Val Leu Asn Ser Ala Ala Asn Ala Ser Ala Thr Thr Thr Glu Pro Leu 
                165                 170                 175


Pro Glu Lys Thr Gln Glu Ser Leu 
            180


<210>  555
<211>  1780
<212>  DNA
<213>  Homo sapiens

<400>  555
atgttgcgag ccacagctcc ctgctggttc ccacctggat acccagaaac taagaaggtg     60

gccgaggagg cggccctcga ggctccagaa ttcccactgc cctctcatca gcctgcccag    120

agcttcgggc tctgggtgcc ccagatgcac aagcaggcct cagcatttgt ggacatccag    180

gcagagcccc agaacagggg tccggcggtg cccccagcgt ggcccaagat ggtgacggag    240

tcgtgctact tccctgcgca gaggggatcg gcctgccgct tgccagccgc cccaaggctg    300

acagagaggc cctcgggagt ccgcatctca gcccccagga agaggaagac gatcgcccac    360

tcttccagcc cttgcttggt cacaggttac acagatgcca agagaacccg ggtggccagc    420

agtagccaac gctccagtgg ctccaaggtc ggcagacagc cagggaagac gcgcaacagg    480

tcagggatgg catgcaagac caccgccacc atcagctcta agcgaatcgt ccgtcgtcca    540

tccttaccga gtttgaagaa acccattatc ctccgaagct ctgggtgcca agtccccacc    600

gtcctccgcc gaggctatct ccaactgttc accgaagagt gtctcaagtt ctgcgcctcc    660

aagcaggagg ccgaggagaa ggcgctgaac gaggagaagg tggcctacga ctgcagcccc    720

aacaagaaca ggtacctgaa cgtggtcctg aacaccctca agagactgaa gggcctgacc    780

cccagctcca tgcccggcct cagcagggcc gccctgtaca gccgcctcca ggagttcctg    840

ctcacccagg accagctcaa ggagaacggc taccccttcc cgcaccccga gcggcccgga    900

ggcgccgtcc tcttcactgg ccaggggaag gggcccggcg actcctcctg cagggtctgc    960

tgccgttgtg gcaccgagta cctggtgtcc tcctcgggcc gctgtgtacg cgaccagttg   1020

tgttattatc actgggggcg ggtccgctcg agccaggtgg ctggaggccg ggttagccag   1080

tacacctgct gtgcagctgc tcctggctct gtgggctgcc aggtggcaaa gcagcacgtg   1140

cgggacggcc gcaaggagag cctcgatggc ttcgtggaga ccttcaagaa agagttgtcc   1200

agagacgctt atccaggaat ctacgccttg gactgtgaga tgtgctacac cacgcatggc   1260

ctagagctga cccgcgtcac cgtggtggac gccgacatgc gagtggtgta cgacaccttc   1320

gtcaagcccg acaacgagat cgtggactac aacaccaggt tttccggagt caccgaggcc   1380

gacgtcgcca agacgagcat cacgttgccc caagtccaag ccatcctgct gagctttttc   1440

agcgcccaaa ccatcctcat cgggcacagc ctggagagcg acctgctggc cctgaagctc   1500

atccacagca ccgtggtgga cacggccgtg ctcttcccgc actacctggg tttcccctac   1560

aagcgctccc tcaggaatct cgcggccgac tacctggcac agatcatcca gaacagccag   1620

gacggccaca actccagcga ggacgcaaac gcctgcctgc agctggtgat gtggaaggtc   1680

cgacagcgcg cccagatcca gccacgccac cggtccgcct ctcccgccgc cctggcctgt   1740

ccttagcccc aggcctcttc caaaactgcc attcgtcccg                         1780


<210>  556
<211>  581
<212>  PRT
<213>  Homo sapiens

<400>  556

Met Leu Arg Ala Thr Ala Pro Cys Trp Phe Pro Pro Gly Tyr Pro Glu 
1               5                   10                  15


Thr Lys Lys Val Ala Glu Glu Ala Ala Leu Glu Ala Pro Glu Phe Pro 
            20                  25                  30


Leu Pro Ser His Gln Pro Ala Gln Ser Phe Gly Leu Trp Val Pro Gln 
        35                  40                  45


Met His Lys Gln Ala Ser Ala Phe Val Asp Ile Gln Ala Glu Pro Gln 
    50                  55                  60


Asn Arg Gly Pro Ala Val Pro Pro Ala Trp Pro Lys Met Val Thr Glu 
65                  70                  75                  80


Ser Cys Tyr Phe Pro Ala Gln Arg Gly Ser Ala Cys Arg Leu Pro Ala 
                85                  90                  95


Ala Pro Arg Leu Thr Glu Arg Pro Ser Gly Val Arg Ile Ser Ala Pro 
            100                 105                 110


Arg Lys Arg Lys Thr Ile Ala His Ser Ser Ser Pro Cys Leu Val Thr 
        115                 120                 125


Gly Tyr Thr Asp Ala Lys Arg Thr Arg Val Ala Ser Ser Ser Gln Arg 
    130                 135                 140


Ser Ser Gly Ser Lys Val Gly Arg Gln Pro Gly Lys Thr Arg Asn Arg 
145                 150                 155                 160


Ser Gly Met Ala Cys Lys Thr Thr Ala Thr Ile Ser Ser Lys Arg Ile 
                165                 170                 175


Val Arg Arg Pro Ser Leu Pro Ser Leu Lys Lys Pro Ile Ile Leu Arg 
            180                 185                 190


Ser Ser Gly Cys Gln Val Pro Thr Val Leu Arg Arg Gly Tyr Leu Gln 
        195                 200                 205


Leu Phe Thr Glu Glu Cys Leu Lys Phe Cys Ala Ser Lys Gln Glu Ala 
    210                 215                 220


Glu Glu Lys Ala Leu Asn Glu Glu Lys Val Ala Tyr Asp Cys Ser Pro 
225                 230                 235                 240


Asn Lys Asn Arg Tyr Leu Asn Val Val Leu Asn Thr Leu Lys Arg Leu 
                245                 250                 255


Lys Gly Leu Thr Pro Ser Ser Met Pro Gly Leu Ser Arg Ala Ala Leu 
            260                 265                 270


Tyr Ser Arg Leu Gln Glu Phe Leu Leu Thr Gln Asp Gln Leu Lys Glu 
        275                 280                 285


Asn Gly Tyr Pro Phe Pro His Pro Glu Arg Pro Gly Gly Ala Val Leu 
    290                 295                 300


Phe Thr Gly Gln Gly Lys Gly Pro Gly Asp Ser Ser Cys Arg Val Cys 
305                 310                 315                 320


Cys Arg Cys Gly Thr Glu Tyr Leu Val Ser Ser Ser Gly Arg Cys Val 
                325                 330                 335


Arg Asp Gln Leu Cys Tyr Tyr His Trp Gly Arg Val Arg Ser Ser Gln 
            340                 345                 350


Val Ala Gly Gly Arg Val Ser Gln Tyr Thr Cys Cys Ala Ala Ala Pro 
        355                 360                 365


Gly Ser Val Gly Cys Gln Val Ala Lys Gln His Val Arg Asp Gly Arg 
    370                 375                 380


Lys Glu Ser Leu Asp Gly Phe Val Glu Thr Phe Lys Lys Glu Leu Ser 
385                 390                 395                 400


Arg Asp Ala Tyr Pro Gly Ile Tyr Ala Leu Asp Cys Glu Met Cys Tyr 
                405                 410                 415


Thr Thr His Gly Leu Glu Leu Thr Arg Val Thr Val Val Asp Ala Asp 
            420                 425                 430


Met Arg Val Val Tyr Asp Thr Phe Val Lys Pro Asp Asn Glu Ile Val 
        435                 440                 445


Asp Tyr Asn Thr Arg Phe Ser Gly Val Thr Glu Ala Asp Val Ala Lys 
    450                 455                 460


Thr Ser Ile Thr Leu Pro Gln Val Gln Ala Ile Leu Leu Ser Phe Phe 
465                 470                 475                 480


Ser Ala Gln Thr Ile Leu Ile Gly His Ser Leu Glu Ser Asp Leu Leu 
                485                 490                 495


Ala Leu Lys Leu Ile His Ser Thr Val Val Asp Thr Ala Val Leu Phe 
            500                 505                 510


Pro His Tyr Leu Gly Phe Pro Tyr Lys Arg Ser Leu Arg Asn Leu Ala 
        515                 520                 525


Ala Asp Tyr Leu Ala Gln Ile Ile Gln Asn Ser Gln Asp Gly His Asn 
    530                 535                 540


Ser Ser Glu Asp Ala Asn Ala Cys Leu Gln Leu Val Met Trp Lys Val 
545                 550                 555                 560


Arg Gln Arg Ala Gln Ile Gln Pro Arg His Arg Ser Ala Ser Pro Ala 
                565                 570                 575


Ala Leu Ala Cys Pro 
            580


<210>  557
<211>  2062
<212>  DNA
<213>  Homo sapiens

<400>  557
atgttgcgag ccacagctcc ctgctggttc ccccctggat acccagaagc taagaaggtg     60

gccgaggagg cggccctgga ggcaagccgc catttgggag gggagcagag ccaggccggt    120

gctcccgaag gcagcaagat gttgcgagcc acagctccct gctggttccg ccctggatac    180

ccagaagcta agaaggtggc caaggaggcg gccccggagg caagccgcca tttgggagcg    240

gagcagagcc cggccggtgc tcccgaaggc agcaagatgt tgcgagccac agctccctgc    300

tggttcccac ctggataccc agaagctaag aaggtggccg aggaggcggc cctcgaggct    360

ccagaattcc cactgccctc tcatcagcct gcccagagct tcgggctctg ggtgccccag    420

atgcacaagc aggcctcagc atttgtggac atccaggcgg agccccagaa caggggtccg    480

gcggtgcccc cagcgtggcc caagatggtg acggagtcgt gctacttccc tgcgcagagg    540

ggatcggcct gccgcttgcc agccgcccca aggctgacag agaggccctc gggagtccgc    600

atctcagccc ccaggaagag gaagacgatc gcccactctt ccagcccttg cttggtcaca    660

ggttacacag atgccaagag aacccgggtg gccagcagca gccaacgctc ccgtggctcc    720

aaggtcggca gacagccagg gaagactcgc aacaggtcag ggatggcatg caagaccacc    780

gccaccacca gctctaagcg aatcgtccgt cgtccatcct taccgagttt gagtttgaag    840

aaacccatta tcctccgaag ctctgggtgc caagtcccca ccgtcctccg ccgaggctat    900

ctccaactgt tcaccgaaga gtgtctcaag ttctgcgcct ccaagcagga ggccgaggag    960

aaggcgctga acgaggagaa ggtggcctac gactgcagcc ccaacaagaa caggtacctg   1020

aacgtggtcc tgaacaccct caagagactg aagggcctga cccccagctc catgcccggc   1080

ctcagcaggg ccgccctgta cagccgcctc caggagttcc tgctcaccca ggaccagctc   1140

aaggagaacg gctacccctt cccgcacccc gagcggcccg gaggcgccgt cctcttcact   1200

ggccagggga aggggcccgg cgactcctcc tgcagggtct gctgccgttg tggcaccgag   1260

tacctggtgt cctcctcggg ccgctgtgta cgcgaccagt tgtgttatta tcactggggg   1320

cgggtccgct cgagccaggt ggctggaggc cgggttagcc agtacacctg ctgtgcagct   1380

gctcctggct ctgtgggctg ccaggtggca aagcagcacg tgcgggacgg ccgcaaggag   1440

agcctcgatg gcttcgtgga gaccttcaag aaagagttgt ccagagacgc ttatccagga   1500

atctacgcct tggactgtga gatgtgctac accacgcatg gcctggagct gacccgcgtc   1560

accgtggtgg acgccgacat gcgagtggtg tacgacacct tcgtcaagcc cgacaacgag   1620

atcgtggact acaacaccag gttttccgga gtcaccgagg ccgacgtcgc caagacgagc   1680

atcacgttgc cccaagtcca agccatcctg ctgagctttt tcagcgccca aaccatcctc   1740

atcgggcaca gcctggagag cgacctgctg gccctgaagc tcatccacaa caccgtggtg   1800

gacacggccg tgctcttccc gcactacctg ggtttcccct acaagcgctc cctcaggaat   1860

ctcgcggccg actacctggc acagatcatc caggacagcc aggacggcca caactccagc   1920

gaggacgcaa acgcctgcct gcagctggtg atgtggaagg tccgacagcg cgcccagatc   1980

cagccacgcc accggtccgc ctctcccgcc gccctggcct gtccttagcc ccaggcctct   2040

tccaaaaccg ccatcagtcc cg                                            2062


<210>  558
<211>  675
<212>  PRT
<213>  Homo sapiens

<400>  558

Met Leu Arg Ala Thr Ala Pro Cys Trp Phe Pro Pro Gly Tyr Pro Glu 
1               5                   10                  15


Ala Lys Lys Val Ala Glu Glu Ala Ala Leu Glu Ala Ser Arg His Leu 
            20                  25                  30


Gly Gly Glu Gln Ser Gln Ala Gly Ala Pro Glu Gly Ser Lys Met Leu 
        35                  40                  45


Arg Ala Thr Ala Pro Cys Trp Phe Arg Pro Gly Tyr Pro Glu Ala Lys 
    50                  55                  60


Lys Val Ala Lys Glu Ala Ala Pro Glu Ala Ser Arg His Leu Gly Ala 
65                  70                  75                  80


Glu Gln Ser Pro Ala Gly Ala Pro Glu Gly Ser Lys Met Leu Arg Ala 
                85                  90                  95


Thr Ala Pro Cys Trp Phe Pro Pro Gly Tyr Pro Glu Ala Lys Lys Val 
            100                 105                 110


Ala Glu Glu Ala Ala Leu Glu Ala Pro Glu Phe Pro Leu Pro Ser His 
        115                 120                 125


Gln Pro Ala Gln Ser Phe Gly Leu Trp Val Pro Gln Met His Lys Gln 
    130                 135                 140


Ala Ser Ala Phe Val Asp Ile Gln Ala Glu Pro Gln Asn Arg Gly Pro 
145                 150                 155                 160


Ala Val Pro Pro Ala Trp Pro Lys Met Val Thr Glu Ser Cys Tyr Phe 
                165                 170                 175


Pro Ala Gln Arg Gly Ser Ala Cys Arg Leu Pro Ala Ala Pro Arg Leu 
            180                 185                 190


Thr Glu Arg Pro Ser Gly Val Arg Ile Ser Ala Pro Arg Lys Arg Lys 
        195                 200                 205


Thr Ile Ala His Ser Ser Ser Pro Cys Leu Val Thr Gly Tyr Thr Asp 
    210                 215                 220


Ala Lys Arg Thr Arg Val Ala Ser Ser Ser Gln Arg Ser Arg Gly Ser 
225                 230                 235                 240


Lys Val Gly Arg Gln Pro Gly Lys Thr Arg Asn Arg Ser Gly Met Ala 
                245                 250                 255


Cys Lys Thr Thr Ala Thr Thr Ser Ser Lys Arg Ile Val Arg Arg Pro 
            260                 265                 270


Ser Leu Pro Ser Leu Ser Leu Lys Lys Pro Ile Ile Leu Arg Ser Ser 
        275                 280                 285


Gly Cys Gln Val Pro Thr Val Leu Arg Arg Gly Tyr Leu Gln Leu Phe 
    290                 295                 300


Thr Glu Glu Cys Leu Lys Phe Cys Ala Ser Lys Gln Glu Ala Glu Glu 
305                 310                 315                 320


Lys Ala Leu Asn Glu Glu Lys Val Ala Tyr Asp Cys Ser Pro Asn Lys 
                325                 330                 335


Asn Arg Tyr Leu Asn Val Val Leu Asn Thr Leu Lys Arg Leu Lys Gly 
            340                 345                 350


Leu Thr Pro Ser Ser Met Pro Gly Leu Ser Arg Ala Ala Leu Tyr Ser 
        355                 360                 365


Arg Leu Gln Glu Phe Leu Leu Thr Gln Asp Gln Leu Lys Glu Asn Gly 
    370                 375                 380


Tyr Pro Phe Pro His Pro Glu Arg Pro Gly Gly Ala Val Leu Phe Thr 
385                 390                 395                 400


Gly Gln Gly Lys Gly Pro Gly Asp Ser Ser Cys Arg Val Cys Cys Arg 
                405                 410                 415


Cys Gly Thr Glu Tyr Leu Val Ser Ser Ser Gly Arg Cys Val Arg Asp 
            420                 425                 430


Gln Leu Cys Tyr Tyr His Trp Gly Arg Val Arg Ser Ser Gln Val Ala 
        435                 440                 445


Gly Gly Arg Val Ser Gln Tyr Thr Cys Cys Ala Ala Ala Pro Gly Ser 
    450                 455                 460


Val Gly Cys Gln Val Ala Lys Gln His Val Arg Asp Gly Arg Lys Glu 
465                 470                 475                 480


Ser Leu Asp Gly Phe Val Glu Thr Phe Lys Lys Glu Leu Ser Arg Asp 
                485                 490                 495


Ala Tyr Pro Gly Ile Tyr Ala Leu Asp Cys Glu Met Cys Tyr Thr Thr 
            500                 505                 510


His Gly Leu Glu Leu Thr Arg Val Thr Val Val Asp Ala Asp Met Arg 
        515                 520                 525


Val Val Tyr Asp Thr Phe Val Lys Pro Asp Asn Glu Ile Val Asp Tyr 
    530                 535                 540


Asn Thr Arg Phe Ser Gly Val Thr Glu Ala Asp Val Ala Lys Thr Ser 
545                 550                 555                 560


Ile Thr Leu Pro Gln Val Gln Ala Ile Leu Leu Ser Phe Phe Ser Ala 
                565                 570                 575


Gln Thr Ile Leu Ile Gly His Ser Leu Glu Ser Asp Leu Leu Ala Leu 
            580                 585                 590


Lys Leu Ile His Asn Thr Val Val Asp Thr Ala Val Leu Phe Pro His 
        595                 600                 605


Tyr Leu Gly Phe Pro Tyr Lys Arg Ser Leu Arg Asn Leu Ala Ala Asp 
    610                 615                 620


Tyr Leu Ala Gln Ile Ile Gln Asp Ser Gln Asp Gly His Asn Ser Ser 
625                 630                 635                 640


Glu Asp Ala Asn Ala Cys Leu Gln Leu Val Met Trp Lys Val Arg Gln 
                645                 650                 655


Arg Ala Gln Ile Gln Pro Arg His Arg Ser Ala Ser Pro Ala Ala Leu 
            660                 665                 670


Ala Cys Pro 
        675


<210>  559
<211>  7032
<212>  DNA
<213>  Homo sapiens

<400>  559
atgttgcgag ccacagctcc ctgctggttc ccccctggat acccagaagc taagaaggtg     60

gccgaggagg cggccctgga ggcaagccgc catttgggag gggagcagag ccaggccggt    120

gctcccgaag gcagcaagat gttgcgagcc acagctccct gctggttccg ccctggatac    180

ccagaagcta agaaggtggc caaggaggcg gccccggagg caagccgcca tttgggagcg    240

gagcagagcc cggccggtgc tcccgaaggc agcaagatgt tgcgagccac agctccctgc    300

tggttcccac ctggataccc agaagctaag aaggtggccg aggaggcggc cctcgaggct    360

ccagaattcc cactgccctc tcatcagcct gcccagagct tcgggctctg ggtgccccag    420

atgcacaagc aggcctcagc atttgtggac atccaggcgg agccccaaaa caggggtccg    480

gcggtgcccc cagcgtggcc caagatggtg acggagtcgt gctacttccc tgcgcagagg    540

ggatcggcct gccgcttgcc agccgcccca aggctgacag agaggccctc gggagtccgc    600

atctcagccc ccaggaagag gaagacgatc gcccactctt ccagcccttg cttggtcaca    660

ggttacacag atgccaagag aacccgggtg gccagcagca gccaacgctc ccgtggctcc    720

aaggtcggca gacagccagg gaagacgcgc aacaggtcag ggatggcatg caagaccacc    780

gccaccacca gctctaagcg aatcgtccgt cgtgcatcct taccgagttt gagtttgaag    840

aaacccatta tcctccgaag ctctgggtgc caagtcccca ccgtcctccg ccgaggctat    900

ctccaactgt tcaccgaaga gtgtctcaag ttctgcgcct ccaagcagga ggccgaggag    960

aaggcgctga acgaggagaa ggtggcctac gactgcagcc ccaacaagaa caggtacctg   1020

aacgtggtcc tgaacaccct caagagactg aagggcctga cccccagctc catgcccggc   1080

ctcagcaggg ccgccctgta cagccgcctc caggagttcc tgctcaccca ggaccagctc   1140

aaggagaacg gctacccctt cccgcacccc gagcggcccg gaggcgccgt cctcttcact   1200

ggccagggga aggggcccgg cgactcctcc tgtagggtct gctgccgttg tggcaccgag   1260

tacctggtgt cctcctcggg ccgctgtgta cgcgaccagt tgtgttatta tcactggggg   1320

cgggtccgct cgagccaggt ggctggaggc cgggttagcc agtacacctg ctgtgcagct   1380

gctcctggct ctgtgggctg ccaggtggca aagcagcacg tgcgggacgg ccgcaaggag   1440

agcctcgatg gcttcgtgga gaccttcaag aaagagttgt ccagagacgc ttatccagga   1500

atctacgcct tggactgtga gatgtgctac accacgcatg gcctagagct gacccgcgtc   1560

accgtggtgg acgccgacat gcgagtggtg tacgacacct tcgtcaagcc cgacaacgag   1620

atcgtggact acaacaccag gttttccgga gtcaccgagg ccgacgtcgc caagacgagc   1680

atcacgttgc cccaagtcca agccatcctg ctgagctttt tcagcgccca aaccatcctc   1740

atcgggcaca gcctggagag cgacctgctg gccctgaagc tcatccacag caccgtggtg   1800

gacacggccg tgctcttccc gcactacctg ggtttcccct acaagcgctc cctcaggaat   1860

ctcgcggccg actacctggc acagatcatc caggacagcc aggacggcca caactccagc   1920

gaggacgcaa gcgcctgcct gcagctggtg atgtggaagg tccgacagcg cgcccagatc   1980

cagccacgcc accggtccgc ctctcccgcc gccctggcct gtccttagcc ccaggcctct   2040

tccaaaaccg ccatcagtcc cgagagctca ccctgcccac ctcgccgcaa agcgaaagaa   2100

actggagcag ccggcggcag gagagggcaa aaagccaaga gtaaccccaa ccccccactc   2160

ccggtccccc ggaatccctg ccgcggcccc tcgggcctgt ccacatccct ctgcccctcc   2220

cagacctctg tccttccacc aatcgcctcc cgcagccccg agccgccact cccagtcccc   2280

cgagtccctg ccgcgcgccc tcgcgcctgt tcacatccct ctgcccatcc gagacctctg   2340

tctttacacc actagccacc ccacgtggga cttccatggc ttctgagtac aaggccagcc   2400

ccccggccca ccagctttcg gaatgcctgc ttacctcttt ttctgtagag gcaccacagg   2460

gaggtgggtg aagcacttcg gctctggagt tacagatctg ggttcaaggc caaattccac   2520

cacttactag gtttgtaata ttggacagat aacgtctttg cgcttctacc ttttggtctt   2580

taaagtgtga tcaaaagaga cttagactcc cacatagtaa taataataat aatggcaaac   2640

ttaacacccc actgtcaaca ttagacacac caacgagaca gaaagttaaa aaaggatatc   2700

cgggaattga actcagctct gcaccaagcg gacctaggag acatgtacag aacgctccac   2760

cccaaatcaa cagaatatac attcttctca gcaccacatc acacttattt ccacattgac   2820

cacatagttg gaagtaaagc actcctcagt aaaagtaaaa taacagaaat tattacaaac   2880

ggtctctcag accacattgc aatcaaacta gacctcagga ttgagaaact cactcaaaac   2940

cgctcaactg catggaaacc gtacaagctg ctcctgaatg agtacagggt acataacgaa   3000

atgaaggcag aaataaagat attctctgaa agcaatgaga acaaagacac aacataccag   3060

aatctctggg acacatttaa agcagtgtgt agagggaaat ttatagcact aaatgcccac   3120

aagggaaagc aggaaagatc aaaaatgcat accctaacat caccattaaa agaatgagag   3180

aagcaagggc aaacacattc aaaagctagc agaaggcaag aaataactaa gatctgagca   3240

ggactgaagg agatagagac acaaaaaacg tgggatggtt ttttagtatg tggaaaaatt   3300

ctttgatggt ttttccttga aaaagtgaaa cctaaatcca ctccgtttgg atgtgggacg   3360

atttgcggtt gttgcttcct aaacataaac tacgtttagg ctgatatttc agacaatgaa   3420

acctttgagt gcccgtagcg ggaagatctc ggttgctgag tgcagggaag gaggatgtaa   3480

ttccatcata tactctctct gtgcctaccg catttggaac catgcgagtg atacctattt   3540

ataaaataaa ataaaccaag cacaagtacg aacttagcaa cactatattg agttaataga   3600

acggtatctt gtatttcttc tgtccaggta tacttataaa tgcctgcagg gatttcacca   3660

cctcagggtg gagagactga atgcttgtga gggaattagg atggtggaat attggtgtta   3720

ccagggaagg gggcgggatg tttgaaaatg ctatgtttac tcgttcttgg gttccaataa   3780

aggagaaaca gggcacagga gtcggaagga ctagtggcaa tagtgatgaa aggacctcct   3840

tatcatgctg gcaatgttaa ttacccaggt gtaggaagcc atacactgag gcggaagatc   3900

gcaagtcaga gtggccggca ggcacaacct cctggcacac cagaggcagg tcttcaatac   3960

ccactggttt ccccaacagg ctgcgtaagg gaccctgagc cacagtgagt tggtcaaatg   4020

ctcctgacag tgtggagaaa ccaacagaca aaacgtgggt gcaaaagtga tgagacccca   4080

cactttacac tcgtggtgac aatgaagcta ttaagtaaca gcttctcaac ctatgctgtt   4140

tcctgttgga tgcacataat ccatttgcac tgcagacaat tttaggatgt ggtttacagt   4200

aaggtggatg gtaccttatg gcaaaaatct ctcagaaatt tatgtgtggt tttaaagtca   4260

ttccagtcct agcacgttgt gcttttcaga gacgccatag ctgtttttcc ctttgtaata   4320

tcaaagcagt aatatgttct ctggaggcct gttgggtgaa tttaatggaa tcaagttaag   4380

taggtgccag aaccattgct gttttccctc catagccctg ccacccactg taaaaaggtt   4440

gatgagatta cttaatgatt tccaattaag ttgtatttcc aaatatcatg atttccattt   4500

taatgtagtt ggtatggagc tctgtgagtg tgtgcttctt ttattatgga tcacgttcag   4560

cttcttttta tttgcctcct agtcataata gtaaaactct actcctctac tccgaggagt   4620

ccctaccacc catctcatca ctttccagcc cagcactctt catgctcatt catttaaagc   4680

attcaacatt gtgtaaatga atcttggaag gccaaagcta ctgaatttag cgaatttgtg   4740

gaggcattgc cacaaatcag ccaggtgaag tttcacacaa tcgaagactg cacaactcct   4800

agaaggcagc actatgctgc aaacccagac ggccactctt ctcacccctc gtccgtttgc   4860

tgttctggat aatgaggttc aaaagtcacc taggcaactg ccaaaatagc tgaaatggag   4920

aaagggcttc aggctggtga ctagcagagg tccacctgac ccccgtaagc tgctgaacaa   4980

gtagggctgc cagaaatgtc ccactaggga atttggtaga gacgaagaca tgctcaccgg   5040

acaagggttc ctcccaggat acgcccgagc ggaagaagcg ggctctgagc cacgcccttt   5100

caccctcctc taccccgccc tgggctggtg aaggtgcgcg ccaggatgtg gactactgag   5160

ccctgaagaa ataagtcctt ccactttgac cccatggagg attgcctgtg aggaacttaa   5220

acgagtctac cagtgtctag acacgggggc aggtctgtcc ggcacagcag ctccctcaag   5280

gaggagaaga gtgaggagaa aggaaactca agtctcacca ttctgtcctg ggagagaaga   5340

ggaggatctc atctctcatc tgtccaaaca aggcaaggag actttctctc atctttccaa   5400

gcaaggcaag gagacttttt atcattagga aacaaaaaga atttagaagg aatgaaagca   5460

gcccgtaagg tgaattccta aggactgccc attgaaactg acaaaattgc ccttgtttga   5520

tgagaggaat gagcagagca ttgatgtggt gaacaaggat ctagtgagac tttcccagca   5580

tgtttctacc aaagctttat ctaagcttct cagaacactc tcctaataag cagatgtttg   5640

gcctttcaga aagtcaacaa gcaaaatgcc ttgagtgtcc caaaacactg atgccatgat   5700

gtgggctcct gactggcctc cttttccttt gactggaccg ctgccacctc ttggtagcca   5760

tcgctttcat gatgctttgc cttggagatc atattggtga agccatgttc caactgccgc   5820

ttacaatttg tcagagggat gcgtcaggat cgtgatccct cctgtttaaa atttccactg   5880

atagctctcg tcgtaaatgc agctgatctg ggcacagtgg ttttcacagc cactgcagga   5940

ttcatcttcc acatcttctc acctcttctt gaaacaagct atacattcgt aaagagttca   6000

tttctttggg gtagtgtcct tacaagcttt tcttaaaacg tcaatgatgt cttcaatctt   6060

ccacccaagc ttcaccataa atttgatgtt tcctcttgct gcaattttcg tggaattcat   6120

gttgctctga cgggagtcct tttcagtgga tgtctcatcc ttcttagtgc ctcaaactag   6180

atctagttca gaaaggttat cagaagttag gacaagttta ttttagtgca aaccagtgga   6240

aatccatgca tagtttcttc accatgtgca ttttctatga acctttggaa gaccacctgt   6300

gttgaacatt gcccaagtcc tgggagagaa gtgggtgcgg tccgcttcct gtcctcaatt   6360

tgcccgcagc ggcggagtgc acagagcagg gaaaggcagc cccagaggga tcccgccctc   6420

cagcatgcag cagactgctg gcccagtcct ggctccaagg ggtgctgtgt gggcccaagc   6480

aagttgacca acctccctga accttaattt aatcctaggt agcccaattc cagtagccat   6540

tataggactg ccctgccggg acagttactt aactcaggaa aagcaaccta gctccaagtt   6600

tagcaaccgg gagttccagt tgattccatt agcgcacccc ctgaggcatt cccaagctgg   6660

agtctggtgg aagatgaggc tcagtgtgat tggactgaag caccaaccta tcaaggagaa   6720

gtcccaccca gtctgccctg tgcctatata aaggcgacaa gtggcggccg cagcactcat   6780

tgaagccgcc agttgggaga ggagcagagc caggccggtg ctcccgaagg cagcaagatg   6840

ttgcgagcca cagctccctg ctggttcccc cctggatacc cagaagctaa gaaggtggcc   6900

gaggaggcgg ccctggaggc aagccgccat ttgggagggg agcagagcca ggccggtgct   6960

cccgaaggca gcaagatgtt gcgagccaca gctccctgct ggttccgccc tggataccca   7020

gaagctaaga ag                                                       7032


<210>  560
<211>  675
<212>  PRT
<213>  Homo sapiens

<400>  560

Met Leu Arg Ala Thr Ala Pro Cys Trp Phe Pro Pro Gly Tyr Pro Glu 
1               5                   10                  15


Ala Lys Lys Val Ala Glu Glu Ala Ala Leu Glu Ala Ser Arg His Leu 
            20                  25                  30


Gly Gly Glu Gln Ser Gln Ala Gly Ala Pro Glu Gly Ser Lys Met Leu 
        35                  40                  45


Arg Ala Thr Ala Pro Cys Trp Phe Arg Pro Gly Tyr Pro Glu Ala Lys 
    50                  55                  60


Lys Val Ala Lys Glu Ala Ala Pro Glu Ala Ser Arg His Leu Gly Ala 
65                  70                  75                  80


Glu Gln Ser Pro Ala Gly Ala Pro Glu Gly Ser Lys Met Leu Arg Ala 
                85                  90                  95


Thr Ala Pro Cys Trp Phe Pro Pro Gly Tyr Pro Glu Ala Lys Lys Val 
            100                 105                 110


Ala Glu Glu Ala Ala Leu Glu Ala Pro Glu Phe Pro Leu Pro Ser His 
        115                 120                 125


Gln Pro Ala Gln Ser Phe Gly Leu Trp Val Pro Gln Met His Lys Gln 
    130                 135                 140


Ala Ser Ala Phe Val Asp Ile Gln Ala Glu Pro Gln Asn Arg Gly Pro 
145                 150                 155                 160


Ala Val Pro Pro Ala Trp Pro Lys Met Val Thr Glu Ser Cys Tyr Phe 
                165                 170                 175


Pro Ala Gln Arg Gly Ser Ala Cys Arg Leu Pro Ala Ala Pro Arg Leu 
            180                 185                 190


Thr Glu Arg Pro Ser Gly Val Arg Ile Ser Ala Pro Arg Lys Arg Lys 
        195                 200                 205


Thr Ile Ala His Ser Ser Ser Pro Cys Leu Val Thr Gly Tyr Thr Asp 
    210                 215                 220


Ala Lys Arg Thr Arg Val Ala Ser Ser Ser Gln Arg Ser Arg Gly Ser 
225                 230                 235                 240


Lys Val Gly Arg Gln Pro Gly Lys Thr Arg Asn Arg Ser Gly Met Ala 
                245                 250                 255


Cys Lys Thr Thr Ala Thr Thr Ser Ser Lys Arg Ile Val Arg Arg Ala 
            260                 265                 270


Ser Leu Pro Ser Leu Ser Leu Lys Lys Pro Ile Ile Leu Arg Ser Ser 
        275                 280                 285


Gly Cys Gln Val Pro Thr Val Leu Arg Arg Gly Tyr Leu Gln Leu Phe 
    290                 295                 300


Thr Glu Glu Cys Leu Lys Phe Cys Ala Ser Lys Gln Glu Ala Glu Glu 
305                 310                 315                 320


Lys Ala Leu Asn Glu Glu Lys Val Ala Tyr Asp Cys Ser Pro Asn Lys 
                325                 330                 335


Asn Arg Tyr Leu Asn Val Val Leu Asn Thr Leu Lys Arg Leu Lys Gly 
            340                 345                 350


Leu Thr Pro Ser Ser Met Pro Gly Leu Ser Arg Ala Ala Leu Tyr Ser 
        355                 360                 365


Arg Leu Gln Glu Phe Leu Leu Thr Gln Asp Gln Leu Lys Glu Asn Gly 
    370                 375                 380


Tyr Pro Phe Pro His Pro Glu Arg Pro Gly Gly Ala Val Leu Phe Thr 
385                 390                 395                 400


Gly Gln Gly Lys Gly Pro Gly Asp Ser Ser Cys Arg Val Cys Cys Arg 
                405                 410                 415


Cys Gly Thr Glu Tyr Leu Val Ser Ser Ser Gly Arg Cys Val Arg Asp 
            420                 425                 430


Gln Leu Cys Tyr Tyr His Trp Gly Arg Val Arg Ser Ser Gln Val Ala 
        435                 440                 445


Gly Gly Arg Val Ser Gln Tyr Thr Cys Cys Ala Ala Ala Pro Gly Ser 
    450                 455                 460


Val Gly Cys Gln Val Ala Lys Gln His Val Arg Asp Gly Arg Lys Glu 
465                 470                 475                 480


Ser Leu Asp Gly Phe Val Glu Thr Phe Lys Lys Glu Leu Ser Arg Asp 
                485                 490                 495


Ala Tyr Pro Gly Ile Tyr Ala Leu Asp Cys Glu Met Cys Tyr Thr Thr 
            500                 505                 510


His Gly Leu Glu Leu Thr Arg Val Thr Val Val Asp Ala Asp Met Arg 
        515                 520                 525


Val Val Tyr Asp Thr Phe Val Lys Pro Asp Asn Glu Ile Val Asp Tyr 
    530                 535                 540


Asn Thr Arg Phe Ser Gly Val Thr Glu Ala Asp Val Ala Lys Thr Ser 
545                 550                 555                 560


Ile Thr Leu Pro Gln Val Gln Ala Ile Leu Leu Ser Phe Phe Ser Ala 
                565                 570                 575


Gln Thr Ile Leu Ile Gly His Ser Leu Glu Ser Asp Leu Leu Ala Leu 
            580                 585                 590


Lys Leu Ile His Ser Thr Val Val Asp Thr Ala Val Leu Phe Pro His 
        595                 600                 605


Tyr Leu Gly Phe Pro Tyr Lys Arg Ser Leu Arg Asn Leu Ala Ala Asp 
    610                 615                 620


Tyr Leu Ala Gln Ile Ile Gln Asp Ser Gln Asp Gly His Asn Ser Ser 
625                 630                 635                 640


Glu Asp Ala Ser Ala Cys Leu Gln Leu Val Met Trp Lys Val Arg Gln 
                645                 650                 655


Arg Ala Gln Ile Gln Pro Arg His Arg Ser Ala Ser Pro Ala Ala Leu 
            660                 665                 670


Ala Cys Pro 
        675


<210>  561
<211>  2062
<212>  DNA
<213>  Homo sapiens

<400>  561
atgttgcgag ccacagctcc ctgctggttc ccccctggat acccagaagc taagaaggtg     60

gccgaggagg cggccctgga ggcaagccgc catctgggag gggagcagag ccaggccggt    120

gctcccgaag gcagcaagat gttgcgagcc acagctccct gctggttccc ccctggatac    180

ccagaagcta agaaggtggc caaggaggcg gccccggagg caagccgcca tttgggagcg    240

gagcagagcc cggccggtgc tcccgaaggc agcaagatgt tgcgagccac agctccctgc    300

tggttcccac ctggataccc agaagctaag aaggtggtcg aggaggcggc cctcgaggct    360

ccagaattcc cactgccctc tcatcagcct gcccagagct tcgggctctg ggtgccccag    420

atgcacaagc aggcctcagc atttgtggac atccaggcgg agccccagaa caggggtccg    480

gcggtgcccc cagcgtggcc caagatggtg acggagtcgt gctacttccc tgcgcagagg    540

ggatcggcct gccgcttgcc agccgcccca aggctgacag agaggccctc gggagtccgc    600

atctcagccc ccaggaagag gaagacgatc gcccactctt ccagcccttg cttggtcaca    660

ggttacacag atgccaagag aacccgggtg gccagcagca gccaacgctc ccgtggctcc    720

aaggtcggca gacagccagg gaagacgcgc aacaggtcag ggatggcatg caagaccacc    780

gccaccacca gctctaagcg aatcgtccgt cgtgcatcct taccgagttt gagtttgaag    840

aaacccatta tcctccgaag ctctgggtgc caagtcccca ccgtcctccg ccgaggctat    900

ctccaactgt tcaccgaaga gtgtctcaag ttctgcgcct ccaagcagga ggccgaggag    960

aaggcgctga acgaggagaa ggtggcctac gactgcagcc ccaacaagaa caggtacctg   1020

aacgtggtcc tgaacaccct caagagactg aagggcctga cccccagctc catgcccggc   1080

ctcagcaggg ccgccctgta cagccgcctc cgggagttcc tgctcaccca ggaccagctc   1140

aaggagaacg gctacccctt cccgcacccc gagcggcccg gaggcgccgt cctcttcact   1200

ggccagggga aggggcccgg cgactcctcc tgcagggtct gctgccgttg tggcaccgag   1260

tacctggtgt cctcctcggg ccgctgtgta cgcgaccagt tgtgttatta tcactggggg   1320

cgggtccgct cgagccaggt ggctggaggc cgggttagcc agtacacctg ctgtgcagct   1380

gctcctggct ctgtgggctg ccaggtggca aagcagcacg tgcgggacgg ccgcaaggag   1440

agcctcgatg gcttcgtgga gaccttcaag aaagagttgt ccagagacgc ttatccagga   1500

atctacgcct tggactgtga gatgtgctac accacgcatg gcctagagct gacccgcatc   1560

accgtggtgg acgccgacat gcgagtggtg tacgacacct tcgtcaagcc cgacaacgag   1620

atcgtggact acaacaccag gttttccgga gtcaccgagg ccgacgtcgc caagacgagc   1680

atcacgttgc cccaagtcca agccatcctg ctgagctttt tcagcgccca aaccatcttc   1740

atcgggcaca gcctggagag cgacctgctg gccctgaagc tcatccacag caccgtggtg   1800

gacacggccg tgctcttccc gcactacctg ggtttcccct acaagcgctc cctcaggaat   1860

ctcgcggccg actacctggc acagatcatc caggacagcc aggacggcca caactccagc   1920

gaggacgcaa acgcctgcct gcagctggtg atgtggaagg tccaacagcg cgcccagatc   1980

cagccacgcc accggtccgc ctctcccgcc gccctggcct gtccttagcc ccaggcctct   2040

tccaaaaccg ccatcagtcc cg                                            2062


<210>  562
<211>  675
<212>  PRT
<213>  Homo sapiens

<400>  562

Met Leu Arg Ala Thr Ala Pro Cys Trp Phe Pro Pro Gly Tyr Pro Glu 
1               5                   10                  15


Ala Lys Lys Val Ala Glu Glu Ala Ala Leu Glu Ala Ser Arg His Leu 
            20                  25                  30


Gly Gly Glu Gln Ser Gln Ala Gly Ala Pro Glu Gly Ser Lys Met Leu 
        35                  40                  45


Arg Ala Thr Ala Pro Cys Trp Phe Pro Pro Gly Tyr Pro Glu Ala Lys 
    50                  55                  60


Lys Val Ala Lys Glu Ala Ala Pro Glu Ala Ser Arg His Leu Gly Ala 
65                  70                  75                  80


Glu Gln Ser Pro Ala Gly Ala Pro Glu Gly Ser Lys Met Leu Arg Ala 
                85                  90                  95


Thr Ala Pro Cys Trp Phe Pro Pro Gly Tyr Pro Glu Ala Lys Lys Val 
            100                 105                 110


Val Glu Glu Ala Ala Leu Glu Ala Pro Glu Phe Pro Leu Pro Ser His 
        115                 120                 125


Gln Pro Ala Gln Ser Phe Gly Leu Trp Val Pro Gln Met His Lys Gln 
    130                 135                 140


Ala Ser Ala Phe Val Asp Ile Gln Ala Glu Pro Gln Asn Arg Gly Pro 
145                 150                 155                 160


Ala Val Pro Pro Ala Trp Pro Lys Met Val Thr Glu Ser Cys Tyr Phe 
                165                 170                 175


Pro Ala Gln Arg Gly Ser Ala Cys Arg Leu Pro Ala Ala Pro Arg Leu 
            180                 185                 190


Thr Glu Arg Pro Ser Gly Val Arg Ile Ser Ala Pro Arg Lys Arg Lys 
        195                 200                 205


Thr Ile Ala His Ser Ser Ser Pro Cys Leu Val Thr Gly Tyr Thr Asp 
    210                 215                 220


Ala Lys Arg Thr Arg Val Ala Ser Ser Ser Gln Arg Ser Arg Gly Ser 
225                 230                 235                 240


Lys Val Gly Arg Gln Pro Gly Lys Thr Arg Asn Arg Ser Gly Met Ala 
                245                 250                 255


Cys Lys Thr Thr Ala Thr Thr Ser Ser Lys Arg Ile Val Arg Arg Ala 
            260                 265                 270


Ser Leu Pro Ser Leu Ser Leu Lys Lys Pro Ile Ile Leu Arg Ser Ser 
        275                 280                 285


Gly Cys Gln Val Pro Thr Val Leu Arg Arg Gly Tyr Leu Gln Leu Phe 
    290                 295                 300


Thr Glu Glu Cys Leu Lys Phe Cys Ala Ser Lys Gln Glu Ala Glu Glu 
305                 310                 315                 320


Lys Ala Leu Asn Glu Glu Lys Val Ala Tyr Asp Cys Ser Pro Asn Lys 
                325                 330                 335


Asn Arg Tyr Leu Asn Val Val Leu Asn Thr Leu Lys Arg Leu Lys Gly 
            340                 345                 350


Leu Thr Pro Ser Ser Met Pro Gly Leu Ser Arg Ala Ala Leu Tyr Ser 
        355                 360                 365


Arg Leu Arg Glu Phe Leu Leu Thr Gln Asp Gln Leu Lys Glu Asn Gly 
    370                 375                 380


Tyr Pro Phe Pro His Pro Glu Arg Pro Gly Gly Ala Val Leu Phe Thr 
385                 390                 395                 400


Gly Gln Gly Lys Gly Pro Gly Asp Ser Ser Cys Arg Val Cys Cys Arg 
                405                 410                 415


Cys Gly Thr Glu Tyr Leu Val Ser Ser Ser Gly Arg Cys Val Arg Asp 
            420                 425                 430


Gln Leu Cys Tyr Tyr His Trp Gly Arg Val Arg Ser Ser Gln Val Ala 
        435                 440                 445


Gly Gly Arg Val Ser Gln Tyr Thr Cys Cys Ala Ala Ala Pro Gly Ser 
    450                 455                 460


Val Gly Cys Gln Val Ala Lys Gln His Val Arg Asp Gly Arg Lys Glu 
465                 470                 475                 480


Ser Leu Asp Gly Phe Val Glu Thr Phe Lys Lys Glu Leu Ser Arg Asp 
                485                 490                 495


Ala Tyr Pro Gly Ile Tyr Ala Leu Asp Cys Glu Met Cys Tyr Thr Thr 
            500                 505                 510


His Gly Leu Glu Leu Thr Arg Ile Thr Val Val Asp Ala Asp Met Arg 
        515                 520                 525


Val Val Tyr Asp Thr Phe Val Lys Pro Asp Asn Glu Ile Val Asp Tyr 
    530                 535                 540


Asn Thr Arg Phe Ser Gly Val Thr Glu Ala Asp Val Ala Lys Thr Ser 
545                 550                 555                 560


Ile Thr Leu Pro Gln Val Gln Ala Ile Leu Leu Ser Phe Phe Ser Ala 
                565                 570                 575


Gln Thr Ile Phe Ile Gly His Ser Leu Glu Ser Asp Leu Leu Ala Leu 
            580                 585                 590


Lys Leu Ile His Ser Thr Val Val Asp Thr Ala Val Leu Phe Pro His 
        595                 600                 605


Tyr Leu Gly Phe Pro Tyr Lys Arg Ser Leu Arg Asn Leu Ala Ala Asp 
    610                 615                 620


Tyr Leu Ala Gln Ile Ile Gln Asp Ser Gln Asp Gly His Asn Ser Ser 
625                 630                 635                 640


Glu Asp Ala Asn Ala Cys Leu Gln Leu Val Met Trp Lys Val Gln Gln 
                645                 650                 655


Arg Ala Gln Ile Gln Pro Arg His Arg Ser Ala Ser Pro Ala Ala Leu 
            660                 665                 670


Ala Cys Pro 
        675


<210>  563
<211>  2062
<212>  DNA
<213>  Homo sapiens

<400>  563
atgttgcgag ccacagctcc ctgctggttc ccccctggat acccagaagc taagaaggtg     60

gccgaggagg cggccctgga ggcaagccgc catttgggag gggagcagag ccaggccggt    120

gctcccgaag gcagcaagat gttgcgagcc acagctccct gctggttccg ccctggatac    180

ccagaagcta agaaggtggc caaggaggcg gccccggagg caagccgcca tttgggagcg    240

gagcagagcc cggccggtgc tcccgaaggc agcaagatgt tgcgagccac agctccctgc    300

tggttcccac ctggataccc agaagctaag aaggtggccg aggaggcggc cctcgaggct    360

ccagaattcc cactgccctc tcatcagcct gcccagagct tcgggctctg ggtgccccag    420

atgcacaagc aggcctcagc atttgtggac atccaggcgg agccccagaa caggggtccg    480

gcggtgcccc cagcgtggcc caagatggtg acggagtcgt gctacttccc tgcgcagagg    540

ggatcggcct gccgcttgcc agccgcccca aggctgacag agaggccctc gggagtccgc    600

atctcagccc ccaggaagag gaagacgatc gcccactctt ccagcccttg cttggtcaca    660

ggttacacag atgccaagag aacccgggtg gccagcagca gccaacgctc ccgtggctcc    720

aaggtcggca gacagccagg gaagacgcgc aacaggtcag ggatggcatg caagaccacc    780

gccaccacca gctctaagcg aatcgtccgt cgtccatcct taccgagttt gagtttgaag    840

aaacccatta tcctccgaag ctctgggtgt caagtcccca ccgtcctccg ccgaggctat    900

ctccaactgt tcaccgaaga gtgtctcaag ttctgcgcct ccaagcagga ggccgaggag    960

aaggcgctga acgaggagaa ggtggcctac gactgcagcc ccaacaagaa caggtacctg   1020

aacgtggtcc tgaacaccct caagagactg aagggcctga cccccagctc catgcccggc   1080

ctcagcaggg ccgccctgta cagccgcctc caggagttcc tgctcaccca ggaccagctc   1140

aaggagaacg gctacccctt cccgcacccc gagcggcccg gaggcgccgt cctcttcact   1200

ggccagggga aggggcccgg cgactcctcc tgcagggtct gctgccgttg tggcaccgag   1260

tacctggtgt cctcctcggg ccgctgtgta cgcgaccagt tgtgttatta tcactggggg   1320

cgggtccgct cgagccaggt ggctggaggc cgggttagcc agtacacctg ctgtgcagct   1380

gctcctggct ctgtgggctg ccaggtggca aagcagcacg tgcgggacgg ccgcaaggag   1440

agcctccatg gcttcgtgga gaccttcaag aaagagttgt ccagagacgc ttatccagga   1500

atctacgcct tggactgtga gatgtgctac accacgcatg gcctagagct ggcccgcgtc   1560

accgtggtgg acgccgacat gcgagtggtg tacgacacct tcgtcaagcc cgacaacgag   1620

atcgtggact acaacaccag gttttccgga gtcaccgagg ccgacgtcgc taagacgagc   1680

atcacgttgc cccaagtcca agccatcctg ctgagctttt tcagcgccca aaccatcctc   1740

atcgggcaca gcctggagag cgacctgctg gccctgaagc tcatccacag caccgtggtg   1800

gacacggccg tgctcttccc gcactacctg ggtttcccct acaagcgctc cctcaggaat   1860

ctcgcggccg actacctggc acagatcatc caggacagcc aggacggcca caactccagc   1920

gaggacgcaa acgcctgcct gcagctggtg atgtggaagg tccgacagcg cgcccagatc   1980

cagccacgcc accggtccgc ctctcccgcc gccctggcct gtccttagcc ccaggcctct   2040

tccaaaaccg ccatcagtcc cg                                            2062


<210>  564
<211>  675
<212>  PRT
<213>  Homo sapiens

<400>  564

Met Leu Arg Ala Thr Ala Pro Cys Trp Phe Pro Pro Gly Tyr Pro Glu 
1               5                   10                  15


Ala Lys Lys Val Ala Glu Glu Ala Ala Leu Glu Ala Ser Arg His Leu 
            20                  25                  30


Gly Gly Glu Gln Ser Gln Ala Gly Ala Pro Glu Gly Ser Lys Met Leu 
        35                  40                  45


Arg Ala Thr Ala Pro Cys Trp Phe Arg Pro Gly Tyr Pro Glu Ala Lys 
    50                  55                  60


Lys Val Ala Lys Glu Ala Ala Pro Glu Ala Ser Arg His Leu Gly Ala 
65                  70                  75                  80


Glu Gln Ser Pro Ala Gly Ala Pro Glu Gly Ser Lys Met Leu Arg Ala 
                85                  90                  95


Thr Ala Pro Cys Trp Phe Pro Pro Gly Tyr Pro Glu Ala Lys Lys Val 
            100                 105                 110


Ala Glu Glu Ala Ala Leu Glu Ala Pro Glu Phe Pro Leu Pro Ser His 
        115                 120                 125


Gln Pro Ala Gln Ser Phe Gly Leu Trp Val Pro Gln Met His Lys Gln 
    130                 135                 140


Ala Ser Ala Phe Val Asp Ile Gln Ala Glu Pro Gln Asn Arg Gly Pro 
145                 150                 155                 160


Ala Val Pro Pro Ala Trp Pro Lys Met Val Thr Glu Ser Cys Tyr Phe 
                165                 170                 175


Pro Ala Gln Arg Gly Ser Ala Cys Arg Leu Pro Ala Ala Pro Arg Leu 
            180                 185                 190


Thr Glu Arg Pro Ser Gly Val Arg Ile Ser Ala Pro Arg Lys Arg Lys 
        195                 200                 205


Thr Ile Ala His Ser Ser Ser Pro Cys Leu Val Thr Gly Tyr Thr Asp 
    210                 215                 220


Ala Lys Arg Thr Arg Val Ala Ser Ser Ser Gln Arg Ser Arg Gly Ser 
225                 230                 235                 240


Lys Val Gly Arg Gln Pro Gly Lys Thr Arg Asn Arg Ser Gly Met Ala 
                245                 250                 255


Cys Lys Thr Thr Ala Thr Thr Ser Ser Lys Arg Ile Val Arg Arg Pro 
            260                 265                 270


Ser Leu Pro Ser Leu Ser Leu Lys Lys Pro Ile Ile Leu Arg Ser Ser 
        275                 280                 285


Gly Cys Gln Val Pro Thr Val Leu Arg Arg Gly Tyr Leu Gln Leu Phe 
    290                 295                 300


Thr Glu Glu Cys Leu Lys Phe Cys Ala Ser Lys Gln Glu Ala Glu Glu 
305                 310                 315                 320


Lys Ala Leu Asn Glu Glu Lys Val Ala Tyr Asp Cys Ser Pro Asn Lys 
                325                 330                 335


Asn Arg Tyr Leu Asn Val Val Leu Asn Thr Leu Lys Arg Leu Lys Gly 
            340                 345                 350


Leu Thr Pro Ser Ser Met Pro Gly Leu Ser Arg Ala Ala Leu Tyr Ser 
        355                 360                 365


Arg Leu Gln Glu Phe Leu Leu Thr Gln Asp Gln Leu Lys Glu Asn Gly 
    370                 375                 380


Tyr Pro Phe Pro His Pro Glu Arg Pro Gly Gly Ala Val Leu Phe Thr 
385                 390                 395                 400


Gly Gln Gly Lys Gly Pro Gly Asp Ser Ser Cys Arg Val Cys Cys Arg 
                405                 410                 415


Cys Gly Thr Glu Tyr Leu Val Ser Ser Ser Gly Arg Cys Val Arg Asp 
            420                 425                 430


Gln Leu Cys Tyr Tyr His Trp Gly Arg Val Arg Ser Ser Gln Val Ala 
        435                 440                 445


Gly Gly Arg Val Ser Gln Tyr Thr Cys Cys Ala Ala Ala Pro Gly Ser 
    450                 455                 460


Val Gly Cys Gln Val Ala Lys Gln His Val Arg Asp Gly Arg Lys Glu 
465                 470                 475                 480


Ser Leu His Gly Phe Val Glu Thr Phe Lys Lys Glu Leu Ser Arg Asp 
                485                 490                 495


Ala Tyr Pro Gly Ile Tyr Ala Leu Asp Cys Glu Met Cys Tyr Thr Thr 
            500                 505                 510


His Gly Leu Glu Leu Ala Arg Val Thr Val Val Asp Ala Asp Met Arg 
        515                 520                 525


Val Val Tyr Asp Thr Phe Val Lys Pro Asp Asn Glu Ile Val Asp Tyr 
    530                 535                 540


Asn Thr Arg Phe Ser Gly Val Thr Glu Ala Asp Val Ala Lys Thr Ser 
545                 550                 555                 560


Ile Thr Leu Pro Gln Val Gln Ala Ile Leu Leu Ser Phe Phe Ser Ala 
                565                 570                 575


Gln Thr Ile Leu Ile Gly His Ser Leu Glu Ser Asp Leu Leu Ala Leu 
            580                 585                 590


Lys Leu Ile His Ser Thr Val Val Asp Thr Ala Val Leu Phe Pro His 
        595                 600                 605


Tyr Leu Gly Phe Pro Tyr Lys Arg Ser Leu Arg Asn Leu Ala Ala Asp 
    610                 615                 620


Tyr Leu Ala Gln Ile Ile Gln Asp Ser Gln Asp Gly His Asn Ser Ser 
625                 630                 635                 640


Glu Asp Ala Asn Ala Cys Leu Gln Leu Val Met Trp Lys Val Arg Gln 
                645                 650                 655


Arg Ala Gln Ile Gln Pro Arg His Arg Ser Ala Ser Pro Ala Ala Leu 
            660                 665                 670


Ala Cys Pro 
        675


<210>  565
<211>  2062
<212>  DNA
<213>  Homo sapiens

<400>  565
atgttgcgag ccacagctcc ctgctggttc ccccctggat acccagaagc taagaaggtg     60

gccgaggagg cggccctgga ggcaagccgc catttgggag gggagcagag ccaggccggt    120

gctcccgaag gcagcaagat gttgcgagcc acagctccct gctggttccg ccctggatac    180

ccagaagcta agaaggtggc caaggaggcg gccccggagg caagccgcca tttgggagcg    240

gagcagagcc cggccggtgc tcccgaaggc agcaagatgt tgcgagccac agctccctgc    300

tggttcccac ctggataccc agaagctaag aaggtggccg aggaggcggc cctcgaggct    360

ccagaattcc cactgccctc tcatcagcct gcccagagct tcgggctctg ggtgccccag    420

atgcacaagc aggcctcagc atttgtggac atccaggcgg agccccagaa caggggtccg    480

gcggtgcccc cagcgtggcc caagatggtg acggagtcgt gctacttccc tgcgcagagg    540

ggatcggcct gccgcttgcc agccgcccca aggctgacag agaggccctc gggagtccgc    600

atctcagccc ccaggaagag gaagacgatc gcccactctt ccagcccttg cttggtcaca    660

ggttacacag atgccaagag aacccgggtg gccagcagca gccaacgctc ccgtggctcc    720

aaggtcggca gacagccagg gaagacgcgc aacaggtcag ggatggcatg caagaccacc    780

gccaccacca gctctaagcg aatcgtccgt cgtccatcct taccgagttt gagtttgaag    840

aaacccatta tcctccgaag ctctgggtgc caagtcccca ccgtcctccg ccgaggctat    900

ctccaactgt tcaccgaaga gtgtctcaag ttctgcgcct ccaagcagga ggccgaggag    960

aaggcgctga acgaggagaa ggtggcctac gactgcagcc ccaacaagaa caggtacctg   1020

aacgtggtcc tgaacaccct caagagactg aagggcctga cccccagctc catgcccggc   1080

ctcagcaggg ccgccctgta cagccgcctc caggagttcc tgctcaccca ggaccagctc   1140

aaggagaacg gctacccctt cccgcacccc gagcggcccg gaggcgccgt cctcttcact   1200

ggccagggga aggggcccgg cgactcctcc tgcagggtct gctgccgttg tggcaccgag   1260

tacctggtgt cctcctcggg ccgctgtgta cgcgaccagt tgtgttatta tcactggggg   1320

cgggtccgct cgagccaggt ggctggaggc cgggttagcc agtacacctg ctgtgcagct   1380

gctcctggct ctgtgggctg ccaggtggca aagcagcacg tgcgggacgg ccgcaaggag   1440

agcctccatg gcttcgtgga gaccttcaag aaagagttgt ccagagacgc ttatccagga   1500

atctacgcct tggactgtga gatgtgctac accacgcatg gcctagagct gacccgcgtc   1560

accgtggtgg acgccgacat gcgagtggtg tacgacacct tcgtcaagcc cgacaacgag   1620

atcgtggact acaacaccag gttttccgga gtcaccgagg ccgacgtcgc caagacgagc   1680

atcacgttgc cccaagtcca agccatcctg ctgagctttt tcagcgccca aaccatcctc   1740

atcgggcaca gcctggagag cgacctgctg gccctgaagc tcatccacag caccgtggtg   1800

gacacggccg tgctcttccc gcactacctg ggtttcccct acaagcgctc cctcaggaat   1860

ctcgcggccg actacctggc acagatcatc caggacagcc aggacggcca caactccagc   1920

gaggacgcaa acgcctgcct gcagctggtg atgtggaagg tccgacagcg cgcccagatc   1980

cagccacgcc accggtccgc atatcccgcc gccttggcct gtctttagcc ccaggcctct   2040

tccaaaaccg ccatcagtcc cg                                            2062


<210>  566
<211>  675
<212>  PRT
<213>  Homo sapiens

<400>  566

Met Leu Arg Ala Thr Ala Pro Cys Trp Phe Pro Pro Gly Tyr Pro Glu 
1               5                   10                  15


Ala Lys Lys Val Ala Glu Glu Ala Ala Leu Glu Ala Ser Arg His Leu 
            20                  25                  30


Gly Gly Glu Gln Ser Gln Ala Gly Ala Pro Glu Gly Ser Lys Met Leu 
        35                  40                  45


Arg Ala Thr Ala Pro Cys Trp Phe Arg Pro Gly Tyr Pro Glu Ala Lys 
    50                  55                  60


Lys Val Ala Lys Glu Ala Ala Pro Glu Ala Ser Arg His Leu Gly Ala 
65                  70                  75                  80


Glu Gln Ser Pro Ala Gly Ala Pro Glu Gly Ser Lys Met Leu Arg Ala 
                85                  90                  95


Thr Ala Pro Cys Trp Phe Pro Pro Gly Tyr Pro Glu Ala Lys Lys Val 
            100                 105                 110


Ala Glu Glu Ala Ala Leu Glu Ala Pro Glu Phe Pro Leu Pro Ser His 
        115                 120                 125


Gln Pro Ala Gln Ser Phe Gly Leu Trp Val Pro Gln Met His Lys Gln 
    130                 135                 140


Ala Ser Ala Phe Val Asp Ile Gln Ala Glu Pro Gln Asn Arg Gly Pro 
145                 150                 155                 160


Ala Val Pro Pro Ala Trp Pro Lys Met Val Thr Glu Ser Cys Tyr Phe 
                165                 170                 175


Pro Ala Gln Arg Gly Ser Ala Cys Arg Leu Pro Ala Ala Pro Arg Leu 
            180                 185                 190


Thr Glu Arg Pro Ser Gly Val Arg Ile Ser Ala Pro Arg Lys Arg Lys 
        195                 200                 205


Thr Ile Ala His Ser Ser Ser Pro Cys Leu Val Thr Gly Tyr Thr Asp 
    210                 215                 220


Ala Lys Arg Thr Arg Val Ala Ser Ser Ser Gln Arg Ser Arg Gly Ser 
225                 230                 235                 240


Lys Val Gly Arg Gln Pro Gly Lys Thr Arg Asn Arg Ser Gly Met Ala 
                245                 250                 255


Cys Lys Thr Thr Ala Thr Thr Ser Ser Lys Arg Ile Val Arg Arg Pro 
            260                 265                 270


Ser Leu Pro Ser Leu Ser Leu Lys Lys Pro Ile Ile Leu Arg Ser Ser 
        275                 280                 285


Gly Cys Gln Val Pro Thr Val Leu Arg Arg Gly Tyr Leu Gln Leu Phe 
    290                 295                 300


Thr Glu Glu Cys Leu Lys Phe Cys Ala Ser Lys Gln Glu Ala Glu Glu 
305                 310                 315                 320


Lys Ala Leu Asn Glu Glu Lys Val Ala Tyr Asp Cys Ser Pro Asn Lys 
                325                 330                 335


Asn Arg Tyr Leu Asn Val Val Leu Asn Thr Leu Lys Arg Leu Lys Gly 
            340                 345                 350


Leu Thr Pro Ser Ser Met Pro Gly Leu Ser Arg Ala Ala Leu Tyr Ser 
        355                 360                 365


Arg Leu Gln Glu Phe Leu Leu Thr Gln Asp Gln Leu Lys Glu Asn Gly 
    370                 375                 380


Tyr Pro Phe Pro His Pro Glu Arg Pro Gly Gly Ala Val Leu Phe Thr 
385                 390                 395                 400


Gly Gln Gly Lys Gly Pro Gly Asp Ser Ser Cys Arg Val Cys Cys Arg 
                405                 410                 415


Cys Gly Thr Glu Tyr Leu Val Ser Ser Ser Gly Arg Cys Val Arg Asp 
            420                 425                 430


Gln Leu Cys Tyr Tyr His Trp Gly Arg Val Arg Ser Ser Gln Val Ala 
        435                 440                 445


Gly Gly Arg Val Ser Gln Tyr Thr Cys Cys Ala Ala Ala Pro Gly Ser 
    450                 455                 460


Val Gly Cys Gln Val Ala Lys Gln His Val Arg Asp Gly Arg Lys Glu 
465                 470                 475                 480


Ser Leu His Gly Phe Val Glu Thr Phe Lys Lys Glu Leu Ser Arg Asp 
                485                 490                 495


Ala Tyr Pro Gly Ile Tyr Ala Leu Asp Cys Glu Met Cys Tyr Thr Thr 
            500                 505                 510


His Gly Leu Glu Leu Thr Arg Val Thr Val Val Asp Ala Asp Met Arg 
        515                 520                 525


Val Val Tyr Asp Thr Phe Val Lys Pro Asp Asn Glu Ile Val Asp Tyr 
    530                 535                 540


Asn Thr Arg Phe Ser Gly Val Thr Glu Ala Asp Val Ala Lys Thr Ser 
545                 550                 555                 560


Ile Thr Leu Pro Gln Val Gln Ala Ile Leu Leu Ser Phe Phe Ser Ala 
                565                 570                 575


Gln Thr Ile Leu Ile Gly His Ser Leu Glu Ser Asp Leu Leu Ala Leu 
            580                 585                 590


Lys Leu Ile His Ser Thr Val Val Asp Thr Ala Val Leu Phe Pro His 
        595                 600                 605


Tyr Leu Gly Phe Pro Tyr Lys Arg Ser Leu Arg Asn Leu Ala Ala Asp 
    610                 615                 620


Tyr Leu Ala Gln Ile Ile Gln Asp Ser Gln Asp Gly His Asn Ser Ser 
625                 630                 635                 640


Glu Asp Ala Asn Ala Cys Leu Gln Leu Val Met Trp Lys Val Arg Gln 
                645                 650                 655


Arg Ala Gln Ile Gln Pro Arg His Arg Ser Ala Tyr Pro Ala Ala Leu 
            660                 665                 670


Ala Cys Leu 
        675


<210>  567
<211>  1780
<212>  DNA
<213>  Homo sapiens

<400>  567
atgttgcgag ccacagctcc ctgctggttc ccacctggat acccagaagc taagaaggtg     60

gccgaggagg cggccctcga ggctccagaa ttcccactgc cctctcatca gcctgcccag    120

agcttcgggc tctgggtgcc ccagatgcac aagcaggcct cagcatttgt ggacatccag    180

gcggagcccc agaacagggg tccggcggtg cccccagcgt ggcccaagat ggtgacggag    240

tcgtgctact tccctgcgca gaggggatcg gcctgccgct tgccagccgc cccaaggctg    300

acagagaggc cctcgggagt ccgcatctca gcccccagga agaggaagac gatcgcccac    360

tcttccagcc cttgcttggt cacaggttac acagatgcca agagaacccg ggtggccagc    420

agcagccaac gctccattgg ctcccaggtc ggcagacagc cagggaagac gcgcaagagg    480

tcagggatgg catgcaagac caccgccacc atcagctcta agcgaatcgt ccgtcgtcta    540

tccttaccga gtttgaagaa acccattatc ctccgaagct ctgggtgcca agtccccacc    600

atcctccgcc gatgctatct ccaactgttc accgaagagt gtctcaagtt ctgcgcctcc    660

aagcaggagg ccgaggagaa ggcgctgaac gaggagaagg tggcctacga ctgcagcccc    720

aacaagaaca ggtacctgaa cgtggtcctg aacaccctca agagactgaa gggcctgacc    780

cccagctcca tgcccggcct cagcagggcc gccctgtaca gccgcctcca ggagttcctg    840

ctcacccagg accagctcaa ggagaacggc taccccttcc cgcaccccga gcggcccgga    900

ggcgccgtcc tcttcactgg ccaggggaag gggcccggcg actcctcctg cagggtctgc    960

tgccgttgtg gcaccgagta cctggtgtcc tccttgggcc gctgtgtacg cgaccagttg   1020

tgttattatc actgggggcg ggtccgctcg agccaggtgg ctggaggccg ggttagccag   1080

tacacctgct gtgcagctgc tcctggctct gtgggctgcc aggtggcaaa gcagcacgtg   1140

cgggacggcc gcaaggagag cctccatggc ttcgtggaga ccttcaagaa agagttgtcc   1200

agagacgctt atccaggaat ctacgccttg gactgtgaga tgtgctacac cacgcatggc   1260

ctagagctga cccgcgtcac cgtggtggac gccgacatgc gagtggtgta cgacaccttc   1320

gtcaagcccg acaacgagat cgtggactac aacaccaggt tttccggagt caccgaggcc   1380

gacgtcgcca agacgagcat cacgttgccc caagtccaag ccatcctgct gagctttttc   1440

agcgcccaaa ccatcctcat cgggcacagc ctggagagcg acctgctggc cctgaagctc   1500

atccacagca ccgtggtgga cacggccgtg ctcttcccgc actacctggg tttcccctac   1560

aagcgctccc tcaggaatct cgcggccgac tacctggcac agatcatcca ggacagccag   1620

gacggccaca actccagcga ggacgcaaac gcctgcctgc agcttggtga tgtggaaggt   1680

caacagcgcg cccagatcca gccacgccac cggtccgcct ctcccgccgc cctggcctgt   1740

ccttagcccc aggcctcttc caaaaccgcc atcagtcccg                         1780


<210>  568
<211>  581
<212>  PRT
<213>  Homo sapiens

<400>  568

Met Leu Arg Ala Thr Ala Pro Cys Trp Phe Pro Pro Gly Tyr Pro Glu 
1               5                   10                  15


Ala Lys Lys Val Ala Glu Glu Ala Ala Leu Glu Ala Pro Glu Phe Pro 
            20                  25                  30


Leu Pro Ser His Gln Pro Ala Gln Ser Phe Gly Leu Trp Val Pro Gln 
        35                  40                  45


Met His Lys Gln Ala Ser Ala Phe Val Asp Ile Gln Ala Glu Pro Gln 
    50                  55                  60


Asn Arg Gly Pro Ala Val Pro Pro Ala Trp Pro Lys Met Val Thr Glu 
65                  70                  75                  80


Ser Cys Tyr Phe Pro Ala Gln Arg Gly Ser Ala Cys Arg Leu Pro Ala 
                85                  90                  95


Ala Pro Arg Leu Thr Glu Arg Pro Ser Gly Val Arg Ile Ser Ala Pro 
            100                 105                 110


Arg Lys Arg Lys Thr Ile Ala His Ser Ser Ser Pro Cys Leu Val Thr 
        115                 120                 125


Gly Tyr Thr Asp Ala Lys Arg Thr Arg Val Ala Ser Ser Ser Gln Arg 
    130                 135                 140


Ser Ile Gly Ser Gln Val Gly Arg Gln Pro Gly Lys Thr Arg Lys Arg 
145                 150                 155                 160


Ser Gly Met Ala Cys Lys Thr Thr Ala Thr Ile Ser Ser Lys Arg Ile 
                165                 170                 175


Val Arg Arg Leu Ser Leu Pro Ser Leu Lys Lys Pro Ile Ile Leu Arg 
            180                 185                 190


Ser Ser Gly Cys Gln Val Pro Thr Ile Leu Arg Arg Cys Tyr Leu Gln 
        195                 200                 205


Leu Phe Thr Glu Glu Cys Leu Lys Phe Cys Ala Ser Lys Gln Glu Ala 
    210                 215                 220


Glu Glu Lys Ala Leu Asn Glu Glu Lys Val Ala Tyr Asp Cys Ser Pro 
225                 230                 235                 240


Asn Lys Asn Arg Tyr Leu Asn Val Val Leu Asn Thr Leu Lys Arg Leu 
                245                 250                 255


Lys Gly Leu Thr Pro Ser Ser Met Pro Gly Leu Ser Arg Ala Ala Leu 
            260                 265                 270


Tyr Ser Arg Leu Gln Glu Phe Leu Leu Thr Gln Asp Gln Leu Lys Glu 
        275                 280                 285


Asn Gly Tyr Pro Phe Pro His Pro Glu Arg Pro Gly Gly Ala Val Leu 
    290                 295                 300


Phe Thr Gly Gln Gly Lys Gly Pro Gly Asp Ser Ser Cys Arg Val Cys 
305                 310                 315                 320


Cys Arg Cys Gly Thr Glu Tyr Leu Val Ser Ser Leu Gly Arg Cys Val 
                325                 330                 335


Arg Asp Gln Leu Cys Tyr Tyr His Trp Gly Arg Val Arg Ser Ser Gln 
            340                 345                 350


Val Ala Gly Gly Arg Val Ser Gln Tyr Thr Cys Cys Ala Ala Ala Pro 
        355                 360                 365


Gly Ser Val Gly Cys Gln Val Ala Lys Gln His Val Arg Asp Gly Arg 
    370                 375                 380


Lys Glu Ser Leu His Gly Phe Val Glu Thr Phe Lys Lys Glu Leu Ser 
385                 390                 395                 400


Arg Asp Ala Tyr Pro Gly Ile Tyr Ala Leu Asp Cys Glu Met Cys Tyr 
                405                 410                 415


Thr Thr His Gly Leu Glu Leu Thr Arg Val Thr Val Val Asp Ala Asp 
            420                 425                 430


Met Arg Val Val Tyr Asp Thr Phe Val Lys Pro Asp Asn Glu Ile Val 
        435                 440                 445


Asp Tyr Asn Thr Arg Phe Ser Gly Val Thr Glu Ala Asp Val Ala Lys 
    450                 455                 460


Thr Ser Ile Thr Leu Pro Gln Val Gln Ala Ile Leu Leu Ser Phe Phe 
465                 470                 475                 480


Ser Ala Gln Thr Ile Leu Ile Gly His Ser Leu Glu Ser Asp Leu Leu 
                485                 490                 495


Ala Leu Lys Leu Ile His Ser Thr Val Val Asp Thr Ala Val Leu Phe 
            500                 505                 510


Pro His Tyr Leu Gly Phe Pro Tyr Lys Arg Ser Leu Arg Asn Leu Ala 
        515                 520                 525


Ala Asp Tyr Leu Ala Gln Ile Ile Gln Asp Ser Gln Asp Gly His Asn 
    530                 535                 540


Ser Ser Glu Asp Ala Asn Ala Cys Leu Gln Leu Gly Asp Val Glu Gly 
545                 550                 555                 560


Gln Gln Arg Ala Gln Ile Gln Pro Arg His Arg Ser Ala Ser Pro Ala 
                565                 570                 575


Ala Leu Ala Cys Pro 
            580


<210>  569
<211>  2370
<212>  DNA
<213>  Homo sapiens

<400>  569
gcaaatcttc aggggccgtc caggactaca gagctgtttc accctacctt ggcttcaatc     60

tcttccccca tgctcgaagg tgcggagctg tacttcaacg tggaccatgg ctacctggag    120

ggcctggttc gaggatgcaa ggccagcctc ctgacccagc aagactatat caacctggtc    180

cagtgtgaga ccctagaaga cctgaaaatt catctccaga ctactgatta tggtaacttt    240

ttggctaatc acacaaatcc tcttactgtt tccaaaattg acactgagat gaggaaaaga    300

ctatgtggag aatttgagta tttccggaat cattccctgg agcccctcag cacatttctc    360

acctatatga cgtgcagtta tatgatagac aatgtgattc tgctgatgaa tggtgcattg    420

cagaaaaaat ctgtgaaaga aattctgggg aagtgccacc ccttgggccg tttcacagaa    480

atggaagctg tcaacattgc agagacacct tcagatctct ttaatgccat tctgatcgaa    540

acgccattag ctccattctt ccaagactgc atgtctgaaa atgctctaga tgaactgaat    600

attgaattgc tacgcaataa actatacaag tcttaccttg aggcattcta taaattctgt    660

aagaatcatg gtgatgtcac agcagaagtt atgtgtccca ttcttgagtt tgaggccgac    720

agacgtgctt ttatcatcac tcttaactcc tttggcactg aattgagcaa agaagaccga    780

gagaccctct atccaacctt cggcaaactc tatcctgagg ggttgcggct gttggctcaa    840

gcagaagact ttgaccagat gaagaacgta gcggatcatt acggagtata caaaccttta    900

tttgaagctg taggtggcag tgggggaaag acattggagg acgtgtttta cgagcgtgag    960

gtacaaatga atgtgctggc attcaacaga cagttccact acggtgtgtt ttatgcatat   1020

gtaaagctga aggaacagga aattagaaat attgtgtgga tagcagaatg tatttcacag   1080

aggcatcgaa ctaaaatcaa cagttacatt ccaattttat aacccaagta aggttctcaa   1140

atgtagaaaa ttataaatgt taaaaggaag ttattgaaga aaataaaaga aattatgtta   1200

tattatctag actacacaaa agtaagccac actatatctt catgagttgc aaatccatgg   1260

aaacacagta aaccagccct gaaacaaagc atttccttgt tttcagtggt attagatctt   1320

gtttccacat gtctgtctca ttcttcactg ggccttacag gttagtttta attaactcta   1380

tggtattttt cttattcttg tttgatcatg ttaaaaattg gacctaataa aagtatttta   1440

ttcttgcttt tccatgcttc tctacaggtc caaatactga atgtctcctt tactttttct   1500

cttttaaatt tttttctaga cagggtctca ctctgtcacc taggctacag tgcagtggtg   1560

tgatcacagc tcactgcagc ctcgacttcc caggctcaag tgatcctccc agctctcagc   1620

ctccaaagta gctggcacta caagtgtaca cccccacaca aggctaagtt ttgtattttt   1680

tgtagagaca gggtttcaac atattatcca ggctggtgtc gaattcctgg gctccaggga   1740

tccacagtcc cccttggcct cccaaagtgt tgggattaca tgcatgagcc actgtgctgg   1800

gcttcattta cattttaact gtctgttcct tgcctagatt cacagaaatc caaagctgta   1860

tgtagtcaac atggttcaca agtgttggaa aatgtgtttt ttgttttgtt ttgttttgtt   1920

tcgttttgtt ttgagacaga gtttccctct gtcgcccagg ctagagtgca atggcgtgat   1980

ctcggctcac tgcaacctcc acctcccaga ttcaagcaac tctctgcctc agcctcccga   2040

gtagctggga ttacaagcac ccaccactac actcagctaa ttttttgtat ttttagtaga   2100

gccggggttt caccatcttg gccaggctga tcttgaactc ctgagctcat gatccacccg   2160

cctcagcctc ccaaagtgct gggattacag gccccttgtt cagccactgc acctggcccc   2220

ttattttgtt tttgttttct aatatacttt gatgtaatca gcttgagaaa gcaacacaat   2280

ttcaaatcct atcttctaga tgcaagcagt gttaaatttg ttaataaatt tgcttttcac   2340

acctttcttt aaataaaagg tatatctctc                                    2370


<210>  570
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  570

Met Leu Glu Gly Ala Glu Leu Tyr Phe Asn Val Asp His Gly Tyr Leu 
1               5                   10                  15


Glu Gly Leu Val Arg Gly Cys Lys Ala Ser Leu Leu Thr Gln Gln Asp 
            20                  25                  30


Tyr Ile Asn Leu Val Gln Cys Glu Thr Leu Glu Asp Leu Lys Ile His 
        35                  40                  45


Leu Gln Thr Thr Asp Tyr Gly Asn Phe Leu Ala Asn His Thr Asn Pro 
    50                  55                  60


Leu Thr Val Ser Lys Ile Asp Thr Glu Met Arg Lys Arg Leu Cys Gly 
65                  70                  75                  80


Glu Phe Glu Tyr Phe Arg Asn His Ser Leu Glu Pro Leu Ser Thr Phe 
                85                  90                  95


Leu Thr Tyr Met Thr Cys Ser Tyr Met Ile Asp Asn Val Ile Leu Leu 
            100                 105                 110


Met Asn Gly Ala Leu Gln Lys Lys Ser Val Lys Glu Ile Leu Gly Lys 
        115                 120                 125


Cys His Pro Leu Gly Arg Phe Thr Glu Met Glu Ala Val Asn Ile Ala 
    130                 135                 140


Glu Thr Pro Ser Asp Leu Phe Asn Ala Ile Leu Ile Glu Thr Pro Leu 
145                 150                 155                 160


Ala Pro Phe Phe Gln Asp Cys Met Ser Glu Asn Ala Leu Asp Glu Leu 
                165                 170                 175


Asn Ile Glu Leu Leu Arg Asn Lys Leu Tyr Lys Ser Tyr Leu Glu Ala 
            180                 185                 190


Phe Tyr Lys Phe Cys Lys Asn His Gly Asp Val Thr Ala Glu Val Met 
        195                 200                 205


Cys Pro Ile Leu Glu Phe Glu Ala Asp Arg Arg Ala Phe Ile Ile Thr 
    210                 215                 220


Leu Asn Ser Phe Gly Thr Glu Leu Ser Lys Glu Asp Arg Glu Thr Leu 
225                 230                 235                 240


Tyr Pro Thr Phe Gly Lys Leu Tyr Pro Glu Gly Leu Arg Leu Leu Ala 
                245                 250                 255


Gln Ala Glu Asp Phe Asp Gln Met Lys Asn Val Ala Asp His Tyr Gly 
            260                 265                 270


Val Tyr Lys Pro Leu Phe Glu Ala Val Gly Gly Ser Gly Gly Lys Thr 
        275                 280                 285


Leu Glu Asp Val Phe Tyr Glu Arg Glu Val Gln Met Asn Val Leu Ala 
    290                 295                 300


Phe Asn Arg Gln Phe His Tyr Gly Val Phe Tyr Ala Tyr Val Lys Leu 
305                 310                 315                 320


Lys Glu Gln Glu Ile Arg Asn Ile Val Trp Ile Ala Glu Cys Ile Ser 
                325                 330                 335


Gln Arg His Arg Thr Lys Ile Asn Ser Tyr Ile Pro Ile Leu 
            340                 345                 350


<210>  571
<211>  1865
<212>  DNA
<213>  Homo sapiens

<400>  571
attttatttc aggaatccat caacatcctt tgcagctaca taggcaggaa aatctagaaa     60

ttgtaattta tatagaattt taaaactctt caattacaat ggatagaggg gagaaaatac    120

agctcaagag agtgtttgga tattggtggg gcacaagttt tttgcttatt aatatcattg    180

gtgcaggaat ttttgtgtcc cccaaaggtg tgttggcata ctcttgcatg aacgtgggag    240

tctccctgtg cgtttgggct ggctgtgcca tactggccat gacatcaact ctttgctctg    300

cagagataag tataagcttc ccatgcagtg gagctcaata ctattttctc aagagatact    360

ttggctccac ggttgctttt ttgaatctct ggacatcctt gtttctgggg tcaggggtag    420

ttgctggcca agctctgctc cttgctgagt acagcatcca gccttttttt cccagctgct    480

ctgtcccaaa gctgcctaag aaatgtctgg cattggccat gttgtggatt gtaggaattc    540

tgacttctcg tggtgtgaaa gaagtgactt ggcttcagat agctagctca gtgctgaaag    600

tgtccatact tagcttcatt tccctaactg gagtagtgtt cctgataaga gggaaaaagg    660

agaatgtaga acgatttcag aatgcttttg atgctgaact tccagatatc tctcacctta    720

tacaagccat cttccaagga tattttgcat attcaggcgg ggcatgcttt acacttatag    780

caggggagct gaagaagccc agaacaacaa ttcccaaatg catatttact gcgttacctc    840

tggtgactgt agtttattta ctggttaaca tttcctatct gactgttctg acacccaggg    900

aaattctctc ttcagatgct gtagctatca catgggctga tcgagctttt ccctcattag    960

catggattat gccttttgct atttctacct cattatttag caaccttctg atttctatat   1020

ttaaatcatc gagaccaata tatcttgcaa gccaagaggg ccagctgcct ttgctattta   1080

atacacttaa tagtcactct tctccattta cagctgtgct actacttgtc actttgggat   1140

cccttgcaat tatcttaaca agtctaattg atttgataaa ctatattttt ttcacgggtt   1200

cattatggtc tatattatta atgataggaa tactaaggcg gagataccag gaacccaatc   1260

tatctatacc ttataaggtg tttttgtcat ttccattagc aacaatagtc atcgacgtgg   1320

gcttggttgt gataccattg gtaaagtctc caaatgtgca ttatgtctac gtgcttctgt   1380

tagttctcag cggattacta ttttacatac ctttaataca ttttaaaata agattggctt   1440

ggtttgagaa gatgacttgc tatttacaat tactatttaa tatttgcctc cctgatgtgt   1500

ctgaggaata gatgtcggaa gtgcaaactc ttaaaaaatt ggccttctaa aaaacatata   1560

tcagattcca aatcaaggtt aaacatatga tagaacattc atggtgaaat tcctatggta   1620

aatatttttt tctcaaatga aataagtaat gtatacaaaa gtgcctaaga cagtacctgg   1680

cttcagagtc actaagaaat tgctaaaagc tctgcttcgc atggtaaaaa acttaagtcc   1740

tggtttgcgt agcttgatag agtgattata caacttccat tctctcactt tttttttctg   1800

tatcccaccc cttttctact gaatttgtgg ggatcctata ataaaagtga atgactaaaa   1860

atttt                                                               1865


<210>  572
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  572

Met Asp Arg Gly Glu Lys Ile Gln Leu Lys Arg Val Phe Gly Tyr Trp 
1               5                   10                  15


Trp Gly Thr Ser Phe Leu Leu Ile Asn Ile Ile Gly Ala Gly Ile Phe 
            20                  25                  30


Val Ser Pro Lys Gly Val Leu Ala Tyr Ser Cys Met Asn Val Gly Val 
        35                  40                  45


Ser Leu Cys Val Trp Ala Gly Cys Ala Ile Leu Ala Met Thr Ser Thr 
    50                  55                  60


Leu Cys Ser Ala Glu Ile Ser Ile Ser Phe Pro Cys Ser Gly Ala Gln 
65                  70                  75                  80


Tyr Tyr Phe Leu Lys Arg Tyr Phe Gly Ser Thr Val Ala Phe Leu Asn 
                85                  90                  95


Leu Trp Thr Ser Leu Phe Leu Gly Ser Gly Val Val Ala Gly Gln Ala 
            100                 105                 110


Leu Leu Leu Ala Glu Tyr Ser Ile Gln Pro Phe Phe Pro Ser Cys Ser 
        115                 120                 125


Val Pro Lys Leu Pro Lys Lys Cys Leu Ala Leu Ala Met Leu Trp Ile 
    130                 135                 140


Val Gly Ile Leu Thr Ser Arg Gly Val Lys Glu Val Thr Trp Leu Gln 
145                 150                 155                 160


Ile Ala Ser Ser Val Leu Lys Val Ser Ile Leu Ser Phe Ile Ser Leu 
                165                 170                 175


Thr Gly Val Val Phe Leu Ile Arg Gly Lys Lys Glu Asn Val Glu Arg 
            180                 185                 190


Phe Gln Asn Ala Phe Asp Ala Glu Leu Pro Asp Ile Ser His Leu Ile 
        195                 200                 205


Gln Ala Ile Phe Gln Gly Tyr Phe Ala Tyr Ser Gly Gly Ala Cys Phe 
    210                 215                 220


Thr Leu Ile Ala Gly Glu Leu Lys Lys Pro Arg Thr Thr Ile Pro Lys 
225                 230                 235                 240


Cys Ile Phe Thr Ala Leu Pro Leu Val Thr Val Val Tyr Leu Leu Val 
                245                 250                 255


Asn Ile Ser Tyr Leu Thr Val Leu Thr Pro Arg Glu Ile Leu Ser Ser 
            260                 265                 270


Asp Ala Val Ala Ile Thr Trp Ala Asp Arg Ala Phe Pro Ser Leu Ala 
        275                 280                 285


Trp Ile Met Pro Phe Ala Ile Ser Thr Ser Leu Phe Ser Asn Leu Leu 
    290                 295                 300


Ile Ser Ile Phe Lys Ser Ser Arg Pro Ile Tyr Leu Ala Ser Gln Glu 
305                 310                 315                 320


Gly Gln Leu Pro Leu Leu Phe Asn Thr Leu Asn Ser His Ser Ser Pro 
                325                 330                 335


Phe Thr Ala Val Leu Leu Leu Val Thr Leu Gly Ser Leu Ala Ile Ile 
            340                 345                 350


Leu Thr Ser Leu Ile Asp Leu Ile Asn Tyr Ile Phe Phe Thr Gly Ser 
        355                 360                 365


Leu Trp Ser Ile Leu Leu Met Ile Gly Ile Leu Arg Arg Arg Tyr Gln 
    370                 375                 380


Glu Pro Asn Leu Ser Ile Pro Tyr Lys Val Phe Leu Ser Phe Pro Leu 
385                 390                 395                 400


Ala Thr Ile Val Ile Asp Val Gly Leu Val Val Ile Pro Leu Val Lys 
                405                 410                 415


Ser Pro Asn Val His Tyr Val Tyr Val Leu Leu Leu Val Leu Ser Gly 
            420                 425                 430


Leu Leu Phe Tyr Ile Pro Leu Ile His Phe Lys Ile Arg Leu Ala Trp 
        435                 440                 445


Phe Glu Lys Met Thr Cys Tyr Leu Gln Leu Leu Phe Asn Ile Cys Leu 
    450                 455                 460


Pro Asp Val Ser Glu Glu 
465                 470


<210>  573
<211>  4347
<212>  DNA
<213>  Homo sapiens

<400>  573
ggcacagtca taaatacaga gggttttcag aaccacctca gagaagatgt ttaaatcgct     60

gacaaaagtc aacaaggtga agcctatagg agagaacaat gagaatgaac aaagttctcg    120

tcggaatgaa gaaggctctc acccaagtaa tcagtctcag caaaccacag cacaggaaga    180

aaacaaaggt gaagagaaat ctctcaaaac caagtcaact ccagtcacgt ctgaagagcc    240

acacaccaac atacaagaca aactctccaa gaaaaattcc tctggagatc tgaccacaaa    300

ccctgaccct caaaatgcag cagaaccaac tggaacagtg ccagagcaga aggaaatgga    360

ccccgggaaa gaaggtccaa acagcccaca aaacaaaccg cctgcagctc ctgttataaa    420

tgagtatgcc gatgcccagc tacacaacct ggtgaaaaga atgcgtcaaa gaacagccct    480

ctacaagaaa aagttggtag agggagatct ctcctcaccc gaagccagcc cacaaactgc    540

aaagcccacg gctgtaccac cagtaaaaga aagcgatgat aagccaacag aacattacta    600

caggctgttg tggttcaaag tcaaaaagat gcctttaaca gagtacttaa agcgaattaa    660

acttccaaac agcatagatt catacacaga tcgactctat ctcctgtggc tcttgcttgt    720

cactcttgcc tataactgga actgctgttt tataccactg cgcctcgtct tcccatatca    780

aaccgcagac aacatacact actggcttat tgcggacatc atatgtgata tcatctacct    840

ttatgatatg ctatttatcc agcccagact ccagtttgta agaggaggag acataatagt    900

ggattcaaat gagctaagga aacactacag gacttctaca aaatttcagt tggatgtcgc    960

atcaataata ccatttgata tttgctacct cttctttggg tttaatccaa tgtttagagc   1020

aaataggatg ttaaagtaca cttcattttt tgaatttaat catcacctag agtctataat   1080

ggacaaagca tatatctaca gagttattcg aacaactgga tacttgctgt ttattctgca   1140

cattaatgcc tgtgtttatt actgggcttc aaactatgaa ggaattggca ctactagatg   1200

ggtgtatgat ggggaaggaa acgagtatct gagatgttat tattgggcag ttcgaacttt   1260

aattaccatt ggtggccttc cagaaccaca aactttattt gaaattgttt ttcaactctt   1320

gaattttttt tctggagttt ttgtgttctc cagtttaatt ggtcagatga gagatgtgat   1380

tggagcagct acagccaatc agaactactt ccgcgcctgc atggatgaca ccattgccta   1440

catgaacaat tactccattc ctaaacttgt gcaaaagcga gttcggactt ggtatgaata   1500

tacatgggac tctcaaagaa tgctagatga gtctgatttg cttaagaccc taccaactac   1560

ggtccagtta gccctcgcca ttgatgtgaa cttcagcatc atcagcaaag tcgacttgtt   1620

caagggttgt gatacacaga tgatttatga catgttgcta agattgaaat ccgttctcta   1680

tttgcctggt gactttgtct gcaaaaaggg agaaattggc aaggaaatgt atatcatcaa   1740

gcatggagaa gtccaagttc ttggaggccc tgatggtact aaagttctgg ttactctgaa   1800

agctgggtcg gtgtttggag aaatcagcct tctagcagca ggaggaggaa accgtcgaac   1860

tgccaatgtg gtggcccacg ggtttgccaa tcttttaact ctagacaaaa agaccctcca   1920

agaaattcta gtgcattatc cagattctga aaggatcctc atgaagaaag ccagagtgct   1980

tttaaagcag aaggctaaga ccgcagaagc aacccctcca agaaaagatc ttgccctcct   2040

cttcccaccg aaagaagaga cacccaaact gtttaaaact ctcctaggag gcacaggaaa   2100

agcaagtctt gcaagactac tcaaattgaa gcgagagcaa gcagctcaga agaaagaaaa   2160

ttctgaagga ggagaggaag aaggaaaaga aaatgaagat aaacaaaaag aaaatgaaga   2220

taaacaaaaa gaaaatgaag ataaaggaaa agaaaatgaa gataaagata aaggaagaga   2280

gccagaagag aagccactgg acagacctga atgtacagca agtcctattg cagtggagga   2340

agaaccccac tcagttagaa ggacagtttt acccagaggg acttctcgtc aatcactcat   2400

tatcagcatg gctccttctg ctgagggcgg agaagaggtt cttactattg aagtcaaaga   2460

aaaggctaag caataaatgt ttgattatct ttagatgtga tatagctagt tcccaaagtg   2520

attgtaccta ggattgtaac ttaaattaac gaggggaaac gacatgctgg gacccttgag   2580

aaacgaaagg caaatcccta gcttagtttc taggacttat ctgagagtgt gatttcatgc   2640

agtggtaata agaagattat taaaagccat ccctattctc cgttttcatt aactttatgc   2700

aattgctata tcttctaatt gtatgtagta agtttccttt tcctttggtt ctttcctgat   2760

gatgtctctt ccttccagtt ttattagctt gctcttggct gtgatgtgat tcactaacct   2820

tttctcttaa tttttattgt gtttaatttc ttctttggca ctctaaagcc tggctaattg   2880

ttctaggttt atgaatttca cctcttacat gtaaagggta taagatttta atgtaatagg   2940

tcaaaaatca gattattttc attcaaatga ggatgatgag tcactgtaat atcaaaaaat   3000

ccccagcagc tgggactgaa gggaagcaga gatcatgaag ctttctgaat gagaagtctg   3060

atttttggaa cagtcccctg aagaccaatg ttggtcggca gaattagcaa actggcaaaa   3120

tcacattgca ggaacatatt ggaaaaattg taccctttac taaagaaata aacttcaata   3180

ttttctcttc taaccaactt aaaagacacc aatctaccta actcatctgg ctcaagggac   3240

ttggactgga ggatacaggc taaagtgaca cttatcagaa tcttcctcaa gcacttgctg   3300

gaaaagatat cagattggaa cttcttgttt aaaattaagc tttagtaaaa caaagtgatg   3360

aggttaggaa ggcagactct acacatgtca gattgacata tccccacaat ttccggaacc   3420

tacatgtata gctgtttaca aaatctccaa gttaattaag ggcactttag gaagttgtcc   3480

tcatgaatta gctagcatta gcataattac cgacgttgca tgctgtgagg aggctacaaa   3540

ggccaggctg gtgtcggaag taataataca tatagaattc cattctaata aatgccatta   3600

gtgtataaca tcaagttctg tgtaatgagg ctatttccaa gtctccaaag atggtcactg   3660

taacagcact ttgctgagag ggttttaaca aatcatatta gccaaaaagc ctacaacata   3720

gatgcattta gcaaaccatg tacaaatcaa tcactataat aaactgcatc atttgataga   3780

gtcaccgttt ttgcatgtag tgttagagta tcacaaaata taacaagttt tactaaagga   3840

tggttggttt tttcaggatt taagggaata tggacaaatt gttaaatagt atttatttga   3900

taaatgggag tttgtatgca gaaagagtga attgcgtata aaaagggtga tttaaaaacc   3960

cagaaacaaa aggtagaata gggctgaagc atctgataat aggaaaagaa aaggacaaaa   4020

gtcctcaact tgtgagcaat atgctttccc tttacaccct gtaatttatt caaatgatat   4080

taaaatacaa gaccattgca atttatgctt ttcgcctggc agttattttc ccccccaagc   4140

tatcctgttt cagataatat caatttattt ccaatccatc agactaaaat ctaagaaaat   4200

tcaagaactc ttttattgtt gatttggtgc caccaaattc tttttctttt taaatctttc   4260

taattatcct ttctttttca atcccattgc taacacccag aacatatttt ctgttcaatg   4320

caaataaaca ttcacttttt acctata                                       4347


<210>  574
<211>  809
<212>  PRT
<213>  Homo sapiens

<400>  574

Met Phe Lys Ser Leu Thr Lys Val Asn Lys Val Lys Pro Ile Gly Glu 
1               5                   10                  15


Asn Asn Glu Asn Glu Gln Ser Ser Arg Arg Asn Glu Glu Gly Ser His 
            20                  25                  30


Pro Ser Asn Gln Ser Gln Gln Thr Thr Ala Gln Glu Glu Asn Lys Gly 
        35                  40                  45


Glu Glu Lys Ser Leu Lys Thr Lys Ser Thr Pro Val Thr Ser Glu Glu 
    50                  55                  60


Pro His Thr Asn Ile Gln Asp Lys Leu Ser Lys Lys Asn Ser Ser Gly 
65                  70                  75                  80


Asp Leu Thr Thr Asn Pro Asp Pro Gln Asn Ala Ala Glu Pro Thr Gly 
                85                  90                  95


Thr Val Pro Glu Gln Lys Glu Met Asp Pro Gly Lys Glu Gly Pro Asn 
            100                 105                 110


Ser Pro Gln Asn Lys Pro Pro Ala Ala Pro Val Ile Asn Glu Tyr Ala 
        115                 120                 125


Asp Ala Gln Leu His Asn Leu Val Lys Arg Met Arg Gln Arg Thr Ala 
    130                 135                 140


Leu Tyr Lys Lys Lys Leu Val Glu Gly Asp Leu Ser Ser Pro Glu Ala 
145                 150                 155                 160


Ser Pro Gln Thr Ala Lys Pro Thr Ala Val Pro Pro Val Lys Glu Ser 
                165                 170                 175


Asp Asp Lys Pro Thr Glu His Tyr Tyr Arg Leu Leu Trp Phe Lys Val 
            180                 185                 190


Lys Lys Met Pro Leu Thr Glu Tyr Leu Lys Arg Ile Lys Leu Pro Asn 
        195                 200                 205


Ser Ile Asp Ser Tyr Thr Asp Arg Leu Tyr Leu Leu Trp Leu Leu Leu 
    210                 215                 220


Val Thr Leu Ala Tyr Asn Trp Asn Cys Cys Phe Ile Pro Leu Arg Leu 
225                 230                 235                 240


Val Phe Pro Tyr Gln Thr Ala Asp Asn Ile His Tyr Trp Leu Ile Ala 
                245                 250                 255


Asp Ile Ile Cys Asp Ile Ile Tyr Leu Tyr Asp Met Leu Phe Ile Gln 
            260                 265                 270


Pro Arg Leu Gln Phe Val Arg Gly Gly Asp Ile Ile Val Asp Ser Asn 
        275                 280                 285


Glu Leu Arg Lys His Tyr Arg Thr Ser Thr Lys Phe Gln Leu Asp Val 
    290                 295                 300


Ala Ser Ile Ile Pro Phe Asp Ile Cys Tyr Leu Phe Phe Gly Phe Asn 
305                 310                 315                 320


Pro Met Phe Arg Ala Asn Arg Met Leu Lys Tyr Thr Ser Phe Phe Glu 
                325                 330                 335


Phe Asn His His Leu Glu Ser Ile Met Asp Lys Ala Tyr Ile Tyr Arg 
            340                 345                 350


Val Ile Arg Thr Thr Gly Tyr Leu Leu Phe Ile Leu His Ile Asn Ala 
        355                 360                 365


Cys Val Tyr Tyr Trp Ala Ser Asn Tyr Glu Gly Ile Gly Thr Thr Arg 
    370                 375                 380


Trp Val Tyr Asp Gly Glu Gly Asn Glu Tyr Leu Arg Cys Tyr Tyr Trp 
385                 390                 395                 400


Ala Val Arg Thr Leu Ile Thr Ile Gly Gly Leu Pro Glu Pro Gln Thr 
                405                 410                 415


Leu Phe Glu Ile Val Phe Gln Leu Leu Asn Phe Phe Ser Gly Val Phe 
            420                 425                 430


Val Phe Ser Ser Leu Ile Gly Gln Met Arg Asp Val Ile Gly Ala Ala 
        435                 440                 445


Thr Ala Asn Gln Asn Tyr Phe Arg Ala Cys Met Asp Asp Thr Ile Ala 
    450                 455                 460


Tyr Met Asn Asn Tyr Ser Ile Pro Lys Leu Val Gln Lys Arg Val Arg 
465                 470                 475                 480


Thr Trp Tyr Glu Tyr Thr Trp Asp Ser Gln Arg Met Leu Asp Glu Ser 
                485                 490                 495


Asp Leu Leu Lys Thr Leu Pro Thr Thr Val Gln Leu Ala Leu Ala Ile 
            500                 505                 510


Asp Val Asn Phe Ser Ile Ile Ser Lys Val Asp Leu Phe Lys Gly Cys 
        515                 520                 525


Asp Thr Gln Met Ile Tyr Asp Met Leu Leu Arg Leu Lys Ser Val Leu 
    530                 535                 540


Tyr Leu Pro Gly Asp Phe Val Cys Lys Lys Gly Glu Ile Gly Lys Glu 
545                 550                 555                 560


Met Tyr Ile Ile Lys His Gly Glu Val Gln Val Leu Gly Gly Pro Asp 
                565                 570                 575


Gly Thr Lys Val Leu Val Thr Leu Lys Ala Gly Ser Val Phe Gly Glu 
            580                 585                 590


Ile Ser Leu Leu Ala Ala Gly Gly Gly Asn Arg Arg Thr Ala Asn Val 
        595                 600                 605


Val Ala His Gly Phe Ala Asn Leu Leu Thr Leu Asp Lys Lys Thr Leu 
    610                 615                 620


Gln Glu Ile Leu Val His Tyr Pro Asp Ser Glu Arg Ile Leu Met Lys 
625                 630                 635                 640


Lys Ala Arg Val Leu Leu Lys Gln Lys Ala Lys Thr Ala Glu Ala Thr 
                645                 650                 655


Pro Pro Arg Lys Asp Leu Ala Leu Leu Phe Pro Pro Lys Glu Glu Thr 
            660                 665                 670


Pro Lys Leu Phe Lys Thr Leu Leu Gly Gly Thr Gly Lys Ala Ser Leu 
        675                 680                 685


Ala Arg Leu Leu Lys Leu Lys Arg Glu Gln Ala Ala Gln Lys Lys Glu 
    690                 695                 700


Asn Ser Glu Gly Gly Glu Glu Glu Gly Lys Glu Asn Glu Asp Lys Gln 
705                 710                 715                 720


Lys Glu Asn Glu Asp Lys Gln Lys Glu Asn Glu Asp Lys Gly Lys Glu 
                725                 730                 735


Asn Glu Asp Lys Asp Lys Gly Arg Glu Pro Glu Glu Lys Pro Leu Asp 
            740                 745                 750


Arg Pro Glu Cys Thr Ala Ser Pro Ile Ala Val Glu Glu Glu Pro His 
        755                 760                 765


Ser Val Arg Arg Thr Val Leu Pro Arg Gly Thr Ser Arg Gln Ser Leu 
    770                 775                 780


Ile Ile Ser Met Ala Pro Ser Ala Glu Gly Gly Glu Glu Val Leu Thr 
785                 790                 795                 800


Ile Glu Val Lys Glu Lys Ala Lys Gln 
                805


<210>  575
<211>  2905
<212>  DNA
<213>  Homo sapiens

<400>  575
cggacgcgtg ggcgggttcg actggagggg cgggggagtc acctgcgagc ggctgcgctg     60

gcggccagcc cgcccaccgc gtctggatcg cgccggctgc gcggggctgc ggacagcaca    120

caccctggaa ggccccggcg gggaacgggc agagtccgcg ccctgcgtcc gcgaccagga    180

ggatcggacc ttcgccttcg ctgtcgccgc cgccgccgcc cgcggccgtc ggggctatta    240

gtgaaagatg gtggatcgct tggcaaacag tgaagcaaat actagacgta taagtatagt    300

ggaaaactgt tttggagcag ctggtcaacc tttaactata cctggacgag ttcttattgg    360

agaaggagta ttgactaagt tgtgcaggaa aaagcccaaa gcaaggcagt ttttcttgtt    420

taatgatatt cttgtatatg gcaatattgt catccagaag aaaaaatata acaaacaaca    480

tattattccc ctggaaaatg tcactattga ttccatcaaa gatgagggag acttaaggaa    540

tggatggcta atcaagacac caactaaatc ttttgcagtt tatgctgcca ctgctacgga    600

gaaatcagaa tggatgaatc atataaataa atgtgttact gatttactct ccaaaagtgg    660

gaagacaccc agtaatgaac atgctgctgt ctgggttcct gactctgagg caactgtatg    720

tatgcgttgt cagaaagcaa aattcacacc tgttaatcgt cgccaccatt gccgcaaatg    780

tggttttgtt gtctgtgggc cctgctctga aaagagattt cttcttccca gccagtcctc    840

taagcctgtg cggatttgtg acttctgcta tgacctgctt tctgctgggg acatggccac    900

atgccagcct gctagatcag actcttacag ccagtcattg aagtctcctt taaatgatat    960

gtctgatgat gatgacgatg atgatagcag tgactaagga cacatttggg agtatttaat   1020

caggtgtggc tatctgagaa atcaactttg ggggaaatgt aagattctga gctctctctc   1080

tgttttgttc tagccatgaa tttgcctgag aaacttgtaa cctatgtgcc tcaatatatt   1140

ccatagaaag taggtccccc tgccttctcc cactcctcac actcttctac agggataggc   1200

ttttgcaaat atatcagata aattttttgt ttcttgttta tttttaggtt attttcttgg   1260

aaggttggga aaagatgttt gttttaacag gtcatgtact acgttgttgt tttcatttct   1320

gttataagta aaactaaaag cacagaatgg tgggaaaggg gctataatgt ggttcattaa   1380

taatgttagc agcttttttc taaccatcct gtctaatggt taagacacca gtaacaaaaa   1440

cacatgattt ggaaatactt tggctttttc atatacctag tggtgcctta tcataatagc   1500

actgttacat gaaataagcc cctaccttct tactttctgg tttgttgaaa aaatacactg   1560

gtgctctttg aagtgataaa atgagtgttt atgaatgggt gtaattagga aatacttctc   1620

atctgacagc tacaaataac taagtttgga ggtattttca ctctatatga ataaatattt   1680

ttccataaaa tagttgtgat tatatttttg ttttatatag gtcccaaatt ataattgtca   1740

aatatatatt ttaaattaat aaaagttgtc attcttagga atttggtttg aaatttatca   1800

gttatacaga attgtcatac tgcattagct tctaccttta gtaagacata ttttttaggt   1860

ataaattctt atgctttaac attatttctg gattgaaaat cttataaaac ccttgaaaat   1920

aaacagtctc ttttttacaa agcctgtgtt agagcacaga tttacctagg cttgaagatt   1980

tggaagaaat aatatgtaag aatggcctca aggcagacca ctttaagttt ggctagactt   2040

catatcgtgg aagtattgtc tatttcagtg tgaaactatc ttgaatttgc aaatatagtg   2100

ttatatttta taaagttttg taaaatccca aacaatattt ctatttttgt aaaacaattg   2160

tatgtataat ctgtatttga aatcattttg caatctatgg aaatagagta gcaattgcta   2220

tttctaaatt gtgaacttta agtcaatcta gatttatttt gagaagtaat tgttcactct   2280

ttacttttga ggcagccatt aggttgaaag tatatattta tcatataaaa cttgatgcgt   2340

tttgcactac tctttccatt tatatgctgc aaacaactac agtctttgaa atatggaaaa   2400

tcagcagtct aaagtttgtt ttaaattcta aatttaaaaa atcttcaaat ctgaatatac   2460

cgcaaatgtc atgagaagtt tgattcagta acttgtgatg gaggattctt tggtatctta   2520

ctgtttggtt aaggcactaa ttttacttac ctattagatt ttgaaagtat ctgagatata   2580

caaatctccc tgtaggaaat gtgaaagaaa agcacaacaa aactagggtt ttttgttcat   2640

ttgcttgctt ttatgatttt ttttggtttg ttttaatatc aggtggattt ttgtttctaa   2700

gcaatatata cataaaatca accaacatat ctgaaaagga tcatgaaacc tgagaaatgc   2760

taatggagat ttgctggtac ataggaatct agcaaattca ggaaccaagg ggaaatgttg   2820

tgagataaca tttacattgt caacctttat tgactttgtt tttacaataa aaaatatttt   2880

acaactcaaa aaaaaaaaaa aaaag                                         2905


<210>  576
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  576

Met Val Asp Arg Leu Ala Asn Ser Glu Ala Asn Thr Arg Arg Ile Ser 
1               5                   10                  15


Ile Val Glu Asn Cys Phe Gly Ala Ala Gly Gln Pro Leu Thr Ile Pro 
            20                  25                  30


Gly Arg Val Leu Ile Gly Glu Gly Val Leu Thr Lys Leu Cys Arg Lys 
        35                  40                  45


Lys Pro Lys Ala Arg Gln Phe Phe Leu Phe Asn Asp Ile Leu Val Tyr 
    50                  55                  60


Gly Asn Ile Val Ile Gln Lys Lys Lys Tyr Asn Lys Gln His Ile Ile 
65                  70                  75                  80


Pro Leu Glu Asn Val Thr Ile Asp Ser Ile Lys Asp Glu Gly Asp Leu 
                85                  90                  95


Arg Asn Gly Trp Leu Ile Lys Thr Pro Thr Lys Ser Phe Ala Val Tyr 
            100                 105                 110


Ala Ala Thr Ala Thr Glu Lys Ser Glu Trp Met Asn His Ile Asn Lys 
        115                 120                 125


Cys Val Thr Asp Leu Leu Ser Lys Ser Gly Lys Thr Pro Ser Asn Glu 
    130                 135                 140


His Ala Ala Val Trp Val Pro Asp Ser Glu Ala Thr Val Cys Met Arg 
145                 150                 155                 160


Cys Gln Lys Ala Lys Phe Thr Pro Val Asn Arg Arg His His Cys Arg 
                165                 170                 175


Lys Cys Gly Phe Val Val Cys Gly Pro Cys Ser Glu Lys Arg Phe Leu 
            180                 185                 190


Leu Pro Ser Gln Ser Ser Lys Pro Val Arg Ile Cys Asp Phe Cys Tyr 
        195                 200                 205


Asp Leu Leu Ser Ala Gly Asp Met Ala Thr Cys Gln Pro Ala Arg Ser 
    210                 215                 220


Asp Ser Tyr Ser Gln Ser Leu Lys Ser Pro Leu Asn Asp Met Ser Asp 
225                 230                 235                 240


Asp Asp Asp Asp Asp Asp Ser Ser Asp 
                245


<210>  577
<211>  2254
<212>  DNA
<213>  Homo sapiens

<400>  577
aaaaggccag gcgattcaag atggcggagg acctggacga gctcttggat gaagtcgagt     60

ccaagttttg cacacctgac cttctaagac ggggtatggt cgagcagccc aaaggctgcg    120

gcggcggcac ccacagtagc gaccggaacc aagccaaggc gaaagagacg ctcagatcaa    180

cagaaacatt taaaaaagaa gatgatcttg acagtcttat taatgaaata cttgaagagc    240

ccaacttgga caaaaaaccc tctaaattaa aatctaaatc ttcaggtaac acatctgtca    300

gagcttccat tgaaggcctt ggtaaaagtt gcagtccggt gtaccttggt gggagctcta    360

ttccatgtgg gattggaaca aatatttcat ggagagcatg tgaccatctg cgttgtatag    420

cctgtgattt cttggtagtc agctatgatg actatatgtg ggacaaatcg tgtgattatc    480

tgtttttcag gaacaacatg ccagaatttc acaaattaaa agcaaagttg ataaagaaga    540

aaggaacacg ggcatatgcc tgccagtgta gctggagaac tattgaagaa gtgactgacc    600

ttcagacaga tcatcagctt cgctgggttt gtggtaaaca ttaagaatgc agactgcaca    660

ttcggacaga tgcatccatg agagtggtct ccatgaatca tcatcatgtt tagacattag    720

tccctagcaa taccattccc tgtgggaaaa ggcagtgaat tttattgata caactacata    780

catttttgaa gaccaaatgg actaaggaag atcatgtatt ataacacttt ggaattattc    840

ctgatacatg gatgtttcac ttagtaacag gcatctacat tctttactaa tctgtcttct    900

gtttaataga ggtttgatta tggagttcca tacaaatatc tagtttttca ttagcaactg    960

caatattgat tgctaatacg tttagcaaat cattccccaa cttgtagcag ttaaagtgga   1020

taaagccggc cagggcaaag agatcattta ggggtgtcta caacacttct tccagtcaga   1080

tcttttgttg ccaaagatca taatttggac atggcagaaa ccaggtgatc agtggctgac   1140

tgaagggtgt tcagaagtag ttacaggtat tttgcaaaaa cactgcctca tagctgatct   1200

tacctcatca actcaaagca atgttatgca caatattaaa tacatgttac cagttttagc   1260

ttatttttcc ctcttttgtt catttaacta tcaaaagtta ttttctattt tgattaccca   1320

ataatatata aaaagagttt gatgcaccca aaatcacaaa aatcctaata catacaggtt   1380

attgttggat tttccaagta ctttctatcc tttaatgcct aaaactccat caagggaagt   1440

aaacagcaag taatataatt tttcaggcag cctgtggact tctctggtag gatcaggttg   1500

acatatcgtt tattaggtga gtaagtgaaa agacaagtaa agcataactg aaccaacagg   1560

taacctgttg ggctccttcc tgacatcact gagatctgag gagccctaca atagcagcac   1620

attcaggaaa tcaggtccct caaaatttct agctcccaac cccattgaga gattttggga   1680

gctttccaat ctgccacaaa ctccctgcta catatgtact atatagttca aatgtgtgat   1740

acagagcacc ctgaaaggga ataattgaaa caaagttata atcttcttag tcttatgcta   1800

aatttattcc agccacccta ctgaagggag gaagatctga tcattagaat ccttttccta   1860

gccatgacac atttacatac ttgtaaaatt tattgtagta agtctagcat tgcaacagaa   1920

tagatcttat aatggccaat cctcacactt ttgtattaag gatattatga cagactaagc   1980

atggtagctc tcgcctgtaa tcccagcact ttgggaggct gaggcaggca gatcagctga   2040

ggtcaggagt tcaagaccag cctggccaac atgataaaac accgtctctg ctagaaatac   2100

aaaaattggc tgggcgcggt ggtgcatgcc tgtgatccca actactcggg aggccgaggc   2160

aggaaaattt attgaacctg ggaggcggag gttgtagtga gccaaggtcg cgccactgcg   2220

ctccagcctg gacaacacag tgagactctg tctc                               2254


<210>  578
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  578

Met Ala Glu Asp Leu Asp Glu Leu Leu Asp Glu Val Glu Ser Lys Phe 
1               5                   10                  15


Cys Thr Pro Asp Leu Leu Arg Arg Gly Met Val Glu Gln Pro Lys Gly 
            20                  25                  30


Cys Gly Gly Gly Thr His Ser Ser Asp Arg Asn Gln Ala Lys Ala Lys 
        35                  40                  45


Glu Thr Leu Arg Ser Thr Glu Thr Phe Lys Lys Glu Asp Asp Leu Asp 
    50                  55                  60


Ser Leu Ile Asn Glu Ile Leu Glu Glu Pro Asn Leu Asp Lys Lys Pro 
65                  70                  75                  80


Ser Lys Leu Lys Ser Lys Ser Ser Gly Asn Thr Ser Val Arg Ala Ser 
                85                  90                  95


Ile Glu Gly Leu Gly Lys Ser Cys Ser Pro Val Tyr Leu Gly Gly Ser 
            100                 105                 110


Ser Ile Pro Cys Gly Ile Gly Thr Asn Ile Ser Trp Arg Ala Cys Asp 
        115                 120                 125


His Leu Arg Cys Ile Ala Cys Asp Phe Leu Val Val Ser Tyr Asp Asp 
    130                 135                 140


Tyr Met Trp Asp Lys Ser Cys Asp Tyr Leu Phe Phe Arg Asn Asn Met 
145                 150                 155                 160


Pro Glu Phe His Lys Leu Lys Ala Lys Leu Ile Lys Lys Lys Gly Thr 
                165                 170                 175


Arg Ala Tyr Ala Cys Gln Cys Ser Trp Arg Thr Ile Glu Glu Val Thr 
            180                 185                 190


Asp Leu Gln Thr Asp His Gln Leu Arg Trp Val Cys Gly Lys His 
        195                 200                 205


<210>  579
<211>  4507
<212>  DNA
<213>  Homo sapiens

<400>  579
tcagcggcag cagccgccgc cgagatgtcc cggcgaaagc aaagcaaacc ccggcagatc     60

aaacggccgc ttgaagatgc cattgaagat gaggaagaag aatgtccatc agaggaaaca    120

gacatcatct ccaaaggaga ctttccattg gaggaaagct tttccacaga atttgggcct    180

gaaaatctga gctgcgaaga agtggaatac ttttgtaaca aaggtgatga tgaaggaatc    240

caggagacag cagaatcaga tggggacaca cagtcagaga aaccggggca acctggagtt    300

gagacagacg actgggatgg accaggagag ctggaggtgt ttcagaaaga tggggaacga    360

aaaattcaga gtcgacagca acttccagtg ggaacaacct gggggccgtt tcctgggaag    420

atggacttga ataataattc tttgaagaca aaggctcagg tcccaatggt gctgactgct    480

ggtcccaagt ggttgctgga tgtgacttgg caaggagtgg aagacaacaa aaacaactgc    540

attgtgtaca gcaaaggggg tcagctttgg tgtacaacta cgaaggccat ctctgagggt    600

gaagagctaa ttgcctttgt ggtggatttt gactcaaggc tacaagctgc cagtcagatg    660

actctcacag aagggatgta ccctgcacgc ctgctggact caattcagct gcttcctcag    720

caagctgcca tggcttctat tttgcccaca gctattgtca ataaggatat attcccttgc    780

aagtcctgtg gcatctggta tcggagtgag cggaatctgc aggcccattt gatgtactac    840

tgcagtggga ggcaaagaga agctgctccg gtgtcagagg aaaatgaaga cagtgcccat    900

cagatttcca gcctgtgccc cttcccacag tgcaccaaga gcttttcaaa tgctcgagct    960

ctagaaatgc acctgaattc acacagtgga gtgaaaatgg aagaattcct gccccctggt   1020

gctagtctaa aatgcaccgt ctgtagctac actgctgatt ccgtgatcaa ctttcaccaa   1080

cacctgttct cccatctcac tcaagctgcc ttccgatgta atcactgcca tttcggcttc   1140

cagactcaga gggagttatt gcagcaccag gagctccatg tccctagcgg caaacttccc   1200

agagaaagtg acatggaaca ctctccaagt gcaactgaag acagcttaca gccagccaca   1260

gacttattga ccagaagcga acttccccag agccaaaagg ccatgcagac taaagatgcg   1320

agctctgaca cagagctgga caagtgtgag aaaaagactc agctctttct cacgaaccag   1380

agaccagaga tacagcctac aacaaataaa caaagctttt cttacacaaa aataaagtct   1440

gagccctcta gcccaagact tgcctcatct ccagttcagc ctaatattgg gccttctttc   1500

cctgtgggcc ctttcctatc tcagttttct ttcccccaag atatcaccat ggtccctcaa   1560

gcttcagaga tcttagctaa gatgtctgaa ctggtgcatc ggcgactgag gcatggcagt   1620

agtagctacc ctcccgtcat ttacagccct ttgatgccca agggggctac ttgttttgag   1680

tgtaacataa cattcaataa tttggataat tatctagtgc acaaaaagca ttattgcagc   1740

agccgatggc agcagatggc taagtcccca gagttcccta gtgtgtcaga aaagatgcct   1800

gaagctttga gtcccaacac tggccaaacc tccataaacc ttctcaaccc agctgctcat   1860

tctgctgatc ctgagaatcc acttcttcaa acatcttgca tcaattcttc cactgtctta   1920

gatttaattg ggccaaatgg gaagggccat gacaaggact tttccactca aactaagaag   1980

ctctccacct ccagtaacaa tgatgacaaa attaatggaa aacctgttga tgtgaaaaat   2040

cccagtgtcc ccttagtgga tggggaaagt gacccaaata agactacctg tgaagcttgc   2100

aacattacct tcagccggca cgaaacatac atggtccaca aacagtatta ctgtgctaca   2160

cgccacgacc ctccactgaa gaggtctgct tccaacaaag tgcctgccat gcagagaacc   2220

atgcgcacac gcaagcgcag aaagatgtat gagatgtgcc tacctgagca ggaacaaagg   2280

cctccactgg ttcagcagag atttcttgac gtagccaacc tcaataatcc ttgtacctcc   2340

actcaagaac ccacagaagg gctaggagag tgctaccacc caagatgtga tatctttcca   2400

ggaattgtct ctaaacactt ggaaacttct ctgacgatca acaagtgtgt tccagtttcc   2460

aaatgtgata ctactcattc cagtgtttcc tgcctagaga tggacgtgcc catagatctc   2520

agcaaaaagt gtttatctca gtctgagcgg acgaccacgt ctcccaaaag gctgctggac   2580

tatcacgagt gcactgtgtg caagatcagt ttcaataagg tagaaaacta tctggcccac   2640

aagcagaatt tctgcccggt tactgcacat cagcgtaatg acctgggtca actggacggc   2700

aaagtgtttc cgaatccaga aagcgaacga aacagccctg atgtcagcta cgaaagaagc   2760

ataataaaat gtgagaaaaa tgggaatttg aagcagcctt cccccaatgg aaacttattt   2820

tcatcccacc tagcaacccc gcaaggcttg aaggtcttta gtgaagctgc tcagctcatt   2880

gctacaaaag aagaaaacag acatttgttt cttccacaat gcctttaccc tggagcaata   2940

aagaaagcaa aaggagccga ccagctttct ccatattatg gaatcaagcc aagtgattat   3000

atttctggtt ctcttgtcat ccataacact gacatcgagc aaagcagaaa tgcagaaaat   3060

gaatctccta aaggccaggc ttcctcaaat gggtgtgctg cgctgaagaa agattctctg   3120

ccattgttgc ccaaaaatcg aggaatggta atagtgaatg gtggactgaa acaagatgag   3180

agacctgctg ccaacccaca gcaagagaac atttcccaga atcctcagca cgaagacgac   3240

cacaaatctc cctcgtggat ctctgagaac ccattagctg ccaatgagaa tgtctcacca   3300

ggaattccct cagcagagga acagttgtct agtatagcaa aaggtgtgaa tggttccagc   3360

caggctccaa ccagtgggaa atattgccgg ctatgtgata tccagttcaa caacctttca   3420

aactttataa ctcacaagaa gttttattgc tcatcacatg cagcagaaca tgtcaaatga   3480

actaactaaa catcagtcac ctttggtatc agtgtttagt atgttgttct aaccagtcca   3540

gaaaaaaaaa taagctgttt gaattacatc tgggcaatca ggagataatt cattatggct   3600

gagttgaaga cttaaggtgt aatttcatta cagtccatta gtaaagtgta ttattggtgc   3660

cattttcaaa aaaattaatt tattttacca gcagtattca tagctgtggt tatgttattt   3720

tttatttaaa aactttatat taaagtcatt tgtaatgtta ttgtatagtt attgtgtagc   3780

acatatggtt tgcactgtat agtagctttt aaagaaaata gtcacaatac agaaaagcat   3840

tttagaaata gcttcaaaag cacttgtgta tcttgatttt ttcttatatg ctgttgcaga   3900

tatatgtata tgctaaaata taacttgcaa agatgttcta aatacacatg ctataagttc   3960

gccttaagat ttcaattctt ggataatcag gctctgtttg cactttatat tttagcagat   4020

acagtctctt agtcactagg ctttgcattt gtatgtagct gtatgtttcc gtccattttc   4080

ttaatcctga acctgtatgt taaatgaaga tggcaatttt tttcttgtat agtacttgta   4140

ttttctttcg ctgatgcagc tctgtctcaa tttttaaacc tttgctgtta aatgcaatac   4200

tttataaaga atgaacaaaa ttactggaag cagtattgta agtaatgagg tagtattaat   4260

cagttttatc ttttgaaagg cacagtctaa atcgaaaccc taaactcaat gctgcaagta   4320

tgaatttaat tcatatataa gatctattta aatataagag tagcaatact gcacctggtg   4380

atcacaaaga taatgttcta cttctgatag aaataatttc tcaacaaatg ttgttactat   4440

gcatgtatat ggatggaata aaattccaga ttgttggaga aaaaaaaaaa aaaaaaaaaa   4500

aaaaaaa                                                             4507


<210>  580
<211>  1151
<212>  PRT
<213>  Homo sapiens

<400>  580

Met Ser Arg Arg Lys Gln Ser Lys Pro Arg Gln Ile Lys Arg Pro Leu 
1               5                   10                  15


Glu Asp Ala Ile Glu Asp Glu Glu Glu Glu Cys Pro Ser Glu Glu Thr 
            20                  25                  30


Asp Ile Ile Ser Lys Gly Asp Phe Pro Leu Glu Glu Ser Phe Ser Thr 
        35                  40                  45


Glu Phe Gly Pro Glu Asn Leu Ser Cys Glu Glu Val Glu Tyr Phe Cys 
    50                  55                  60


Asn Lys Gly Asp Asp Glu Gly Ile Gln Glu Thr Ala Glu Ser Asp Gly 
65                  70                  75                  80


Asp Thr Gln Ser Glu Lys Pro Gly Gln Pro Gly Val Glu Thr Asp Asp 
                85                  90                  95


Trp Asp Gly Pro Gly Glu Leu Glu Val Phe Gln Lys Asp Gly Glu Arg 
            100                 105                 110


Lys Ile Gln Ser Arg Gln Gln Leu Pro Val Gly Thr Thr Trp Gly Pro 
        115                 120                 125


Phe Pro Gly Lys Met Asp Leu Asn Asn Asn Ser Leu Lys Thr Lys Ala 
    130                 135                 140


Gln Val Pro Met Val Leu Thr Ala Gly Pro Lys Trp Leu Leu Asp Val 
145                 150                 155                 160


Thr Trp Gln Gly Val Glu Asp Asn Lys Asn Asn Cys Ile Val Tyr Ser 
                165                 170                 175


Lys Gly Gly Gln Leu Trp Cys Thr Thr Thr Lys Ala Ile Ser Glu Gly 
            180                 185                 190


Glu Glu Leu Ile Ala Phe Val Val Asp Phe Asp Ser Arg Leu Gln Ala 
        195                 200                 205


Ala Ser Gln Met Thr Leu Thr Glu Gly Met Tyr Pro Ala Arg Leu Leu 
    210                 215                 220


Asp Ser Ile Gln Leu Leu Pro Gln Gln Ala Ala Met Ala Ser Ile Leu 
225                 230                 235                 240


Pro Thr Ala Ile Val Asn Lys Asp Ile Phe Pro Cys Lys Ser Cys Gly 
                245                 250                 255


Ile Trp Tyr Arg Ser Glu Arg Asn Leu Gln Ala His Leu Met Tyr Tyr 
            260                 265                 270


Cys Ser Gly Arg Gln Arg Glu Ala Ala Pro Val Ser Glu Glu Asn Glu 
        275                 280                 285


Asp Ser Ala His Gln Ile Ser Ser Leu Cys Pro Phe Pro Gln Cys Thr 
    290                 295                 300


Lys Ser Phe Ser Asn Ala Arg Ala Leu Glu Met His Leu Asn Ser His 
305                 310                 315                 320


Ser Gly Val Lys Met Glu Glu Phe Leu Pro Pro Gly Ala Ser Leu Lys 
                325                 330                 335


Cys Thr Val Cys Ser Tyr Thr Ala Asp Ser Val Ile Asn Phe His Gln 
            340                 345                 350


His Leu Phe Ser His Leu Thr Gln Ala Ala Phe Arg Cys Asn His Cys 
        355                 360                 365


His Phe Gly Phe Gln Thr Gln Arg Glu Leu Leu Gln His Gln Glu Leu 
    370                 375                 380


His Val Pro Ser Gly Lys Leu Pro Arg Glu Ser Asp Met Glu His Ser 
385                 390                 395                 400


Pro Ser Ala Thr Glu Asp Ser Leu Gln Pro Ala Thr Asp Leu Leu Thr 
                405                 410                 415


Arg Ser Glu Leu Pro Gln Ser Gln Lys Ala Met Gln Thr Lys Asp Ala 
            420                 425                 430


Ser Ser Asp Thr Glu Leu Asp Lys Cys Glu Lys Lys Thr Gln Leu Phe 
        435                 440                 445


Leu Thr Asn Gln Arg Pro Glu Ile Gln Pro Thr Thr Asn Lys Gln Ser 
    450                 455                 460


Phe Ser Tyr Thr Lys Ile Lys Ser Glu Pro Ser Ser Pro Arg Leu Ala 
465                 470                 475                 480


Ser Ser Pro Val Gln Pro Asn Ile Gly Pro Ser Phe Pro Val Gly Pro 
                485                 490                 495


Phe Leu Ser Gln Phe Ser Phe Pro Gln Asp Ile Thr Met Val Pro Gln 
            500                 505                 510


Ala Ser Glu Ile Leu Ala Lys Met Ser Glu Leu Val His Arg Arg Leu 
        515                 520                 525


Arg His Gly Ser Ser Ser Tyr Pro Pro Val Ile Tyr Ser Pro Leu Met 
    530                 535                 540


Pro Lys Gly Ala Thr Cys Phe Glu Cys Asn Ile Thr Phe Asn Asn Leu 
545                 550                 555                 560


Asp Asn Tyr Leu Val His Lys Lys His Tyr Cys Ser Ser Arg Trp Gln 
                565                 570                 575


Gln Met Ala Lys Ser Pro Glu Phe Pro Ser Val Ser Glu Lys Met Pro 
            580                 585                 590


Glu Ala Leu Ser Pro Asn Thr Gly Gln Thr Ser Ile Asn Leu Leu Asn 
        595                 600                 605


Pro Ala Ala His Ser Ala Asp Pro Glu Asn Pro Leu Leu Gln Thr Ser 
    610                 615                 620


Cys Ile Asn Ser Ser Thr Val Leu Asp Leu Ile Gly Pro Asn Gly Lys 
625                 630                 635                 640


Gly His Asp Lys Asp Phe Ser Thr Gln Thr Lys Lys Leu Ser Thr Ser 
                645                 650                 655


Ser Asn Asn Asp Asp Lys Ile Asn Gly Lys Pro Val Asp Val Lys Asn 
            660                 665                 670


Pro Ser Val Pro Leu Val Asp Gly Glu Ser Asp Pro Asn Lys Thr Thr 
        675                 680                 685


Cys Glu Ala Cys Asn Ile Thr Phe Ser Arg His Glu Thr Tyr Met Val 
    690                 695                 700


His Lys Gln Tyr Tyr Cys Ala Thr Arg His Asp Pro Pro Leu Lys Arg 
705                 710                 715                 720


Ser Ala Ser Asn Lys Val Pro Ala Met Gln Arg Thr Met Arg Thr Arg 
                725                 730                 735


Lys Arg Arg Lys Met Tyr Glu Met Cys Leu Pro Glu Gln Glu Gln Arg 
            740                 745                 750


Pro Pro Leu Val Gln Gln Arg Phe Leu Asp Val Ala Asn Leu Asn Asn 
        755                 760                 765


Pro Cys Thr Ser Thr Gln Glu Pro Thr Glu Gly Leu Gly Glu Cys Tyr 
    770                 775                 780


His Pro Arg Cys Asp Ile Phe Pro Gly Ile Val Ser Lys His Leu Glu 
785                 790                 795                 800


Thr Ser Leu Thr Ile Asn Lys Cys Val Pro Val Ser Lys Cys Asp Thr 
                805                 810                 815


Thr His Ser Ser Val Ser Cys Leu Glu Met Asp Val Pro Ile Asp Leu 
            820                 825                 830


Ser Lys Lys Cys Leu Ser Gln Ser Glu Arg Thr Thr Thr Ser Pro Lys 
        835                 840                 845


Arg Leu Leu Asp Tyr His Glu Cys Thr Val Cys Lys Ile Ser Phe Asn 
    850                 855                 860


Lys Val Glu Asn Tyr Leu Ala His Lys Gln Asn Phe Cys Pro Val Thr 
865                 870                 875                 880


Ala His Gln Arg Asn Asp Leu Gly Gln Leu Asp Gly Lys Val Phe Pro 
                885                 890                 895


Asn Pro Glu Ser Glu Arg Asn Ser Pro Asp Val Ser Tyr Glu Arg Ser 
            900                 905                 910


Ile Ile Lys Cys Glu Lys Asn Gly Asn Leu Lys Gln Pro Ser Pro Asn 
        915                 920                 925


Gly Asn Leu Phe Ser Ser His Leu Ala Thr Pro Gln Gly Leu Lys Val 
    930                 935                 940


Phe Ser Glu Ala Ala Gln Leu Ile Ala Thr Lys Glu Glu Asn Arg His 
945                 950                 955                 960


Leu Phe Leu Pro Gln Cys Leu Tyr Pro Gly Ala Ile Lys Lys Ala Lys 
                965                 970                 975


Gly Ala Asp Gln Leu Ser Pro Tyr Tyr Gly Ile Lys Pro Ser Asp Tyr 
            980                 985                 990


Ile Ser Gly Ser Leu Val Ile His Asn Thr Asp Ile Glu Gln Ser Arg 
        995                 1000                1005


Asn Ala Glu Asn Glu Ser Pro Lys Gly Gln Ala Ser Ser Asn Gly Cys 
    1010                1015                1020


Ala Ala Leu Lys Lys Asp Ser Leu Pro Leu Leu Pro Lys Asn Arg Gly 
1025                1030                1035                1040


Met Val Ile Val Asn Gly Gly Leu Lys Gln Asp Glu Arg Pro Ala Ala 
                1045                1050                1055


Asn Pro Gln Gln Glu Asn Ile Ser Gln Asn Pro Gln His Glu Asp Asp 
            1060                1065                1070


His Lys Ser Pro Ser Trp Ile Ser Glu Asn Pro Leu Ala Ala Asn Glu 
        1075                1080                1085


Asn Val Ser Pro Gly Ile Pro Ser Ala Glu Glu Gln Leu Ser Ser Ile 
    1090                1095                1100


Ala Lys Gly Val Asn Gly Ser Ser Gln Ala Pro Thr Ser Gly Lys Tyr 
1105                1110                1115                1120


Cys Arg Leu Cys Asp Ile Gln Phe Asn Asn Leu Ser Asn Phe Ile Thr 
                1125                1130                1135


His Lys Lys Phe Tyr Cys Ser Ser His Ala Ala Glu His Val Lys 
            1140                1145                1150


<210>  581
<211>  2842
<212>  DNA
<213>  Homo sapiens

<400>  581
tggaattcca gagctgccag gcgctcccag ccggtctcgg caaacttttc cccagcccac     60

gtgctaacca agcggctctc ttcccgagcc cgggatggag caccgcgcct agggaggccg    120

cgccgcccga gacgtgcgca cggttcgtgg cggagagatg ctgatcgcgc tgaactgacc    180

ggtgcggccc gggggtgagt ggcgagtctc cctctgagtc ctccccagca gcgcggccgg    240

cgccggctct ttgggcgaac cctccagttc ctagactttg agaggcgtct ctcccccgcc    300

cgaccgccca gatgcagttt cgccttttct cctttgccct catcattctg aactgcatgg    360

attacagcca ctgccaaggc aaccgatgga gacgcagtaa gcgagctagt tatgtatcaa    420

atcccatttg caagggttgt ttgtcttgtt caaaggacaa tgggtgtagc cgatgtcaac    480

agaagttgtt cttcttcctt cgaagagaag ggatgcgcca gtatggagag tgcctgcatt    540

cctgcccatc cgggtactat ggacaccgag ccccagatat gaacagatgt gcaagatgca    600

gaatagaaaa ctgtgattct tgctttagca aagacttttg taccaagtgc aaagtaggct    660

tttatttgca tagaggccgt tgctttgatg aatgtccaga tggttttgca ccattagaag    720

aaaccatgga atgtgtggaa ggatgtgaag ttggtcattg gagcgaatgg ggaacttgta    780

gcagaaataa tcgcacatgt ggatttaaat ggggtctgga aaccagaaca cggcaaattg    840

ttaaaaagcc agtgaaagac acaataccgt gtccaaccat tgctgaatcc aggagatgca    900

agatgacaat gaggcattgt ccaggaggga agagaacacc aaaggcgaag gagaagagga    960

acaagaaaaa gaaaaggaag ctgatagaaa gggcccagga gcaacacagc gtcttcctag   1020

ctacagacag agctaaccaa taaaacaaga gatccggtag atttttaggg gtttttgttt   1080

ttgcaaatgt gcacaaagct actctccact cctgcacact ggtgtgcagc ctttgtgctg   1140

ctctgcccag tatctgttcc cagtaacatg gtgaaaggaa gcaccaccag catggcccct   1200

gtgttattta tgctttgatt tgaatctgga gactgtgaag gcaggagtaa gtgcacagcc   1260

cgtgacttgg ctcagtgtgt gctgagagaa tccgtccccg gcaccatgga catgctagag   1320

gtgtgaggct gcagaacacc gctggaggac ggacttgtgc ctatttatgt gaaagaagat   1380

gcttggcagg caatgcgcta ctcactcgtg acctttattt ctcacattgt gcattttcaa   1440

ggatatgttt gtgtggatat ctgcttagtg ttaccacatg gtattctcag catgttacct   1500

tcacactgtt gtgcgatgaa actgctttta gctgaggata tgctctggaa attcctgctc   1560

agtttcactg cagccctaat atgtacatat actgcaggag ctacatataa agctcttatt   1620

tactgtatat ttatgctttc ttgtgggtaa caagtcatac ctgattaata tgatgccact   1680

ttgtttctag tggttcctaa cccattgtct gataaatgac ttttctagtt tggggaattg   1740

acacttgttt tgttgcctct tgaaactttt tttttttccc ctcattgtgg gcttatttct   1800

cattgtaagg gtaggataaa ctagtttttg tatatagagt caaatgacca gtgtcaaaga   1860

gtttgcatat tgggtagacc ttctccactc cacatgtccc acacatatag ataaagcagc   1920

aggcggcatc tggcaatcag aagcccaaac tgcctttgag tctaagatgt gatgactttg   1980

atgaaacaca actgaaaaca tgagggacta tatccagtca cttgtagcca gtttcacagg   2040

ccagctacag aattgtccaa acaaacatta tttctgactg caattttttt cccccaaatt   2100

taaagcaatc cctggcttta aatgacaagg cacctaccaa tgttcttggg tcactgaaga   2160

agctactacc atgagcctgt gcatagaatt ttaggagata aaaggatgaa tttctgtgac   2220

tgccagtcag atcttaacag gtttctgttg agccagaatc tgtttcagat ccaagatgga   2280

gaggaacact atggaaactt cccaggtgac tttcagagca gttgtttcaa acacatcatt   2340

gtccttttag gggaaccagt ttttagaagg ttgtgaattg gctttttcac aaagcatgat   2400

tatcttcctg gctgatccag gagaaaatta gaacagaaaa ataatggttg tggattttga   2460

aacaaagcaa ggtaaagcct tttttttttc accttgcatt ggcaaaacta cctcttcagt   2520

gtttttaact tttgattcaa aagcatctta ccaataagga taaatatcat atacatcgtt   2580

atgaaaatat tgctatgaga taataagcca catatgaatg ttgtatacaa ctttagggtt   2640

tacatttaat cctgaagtgt tacctccttt catgtctatt tacactattt tcccatttac   2700

taagtgggga gggggtctcc ttatatagtg cttcatcgtt aataagtcaa tacctgttgt   2760

tcctgggatg ttcttttttg tgcattaaaa acttcaaaat taaaaaaaaa aaaaaaaaaa   2820

aaaaaaaaaa aaaaaaaaaa ag                                            2842


<210>  582
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  582

Met Gln Phe Arg Leu Phe Ser Phe Ala Leu Ile Ile Leu Asn Cys Met 
1               5                   10                  15


Asp Tyr Ser His Cys Gln Gly Asn Arg Trp Arg Arg Ser Lys Arg Ala 
            20                  25                  30


Ser Tyr Val Ser Asn Pro Ile Cys Lys Gly Cys Leu Ser Cys Ser Lys 
        35                  40                  45


Asp Asn Gly Cys Ser Arg Cys Gln Gln Lys Leu Phe Phe Phe Leu Arg 
    50                  55                  60


Arg Glu Gly Met Arg Gln Tyr Gly Glu Cys Leu His Ser Cys Pro Ser 
65                  70                  75                  80


Gly Tyr Tyr Gly His Arg Ala Pro Asp Met Asn Arg Cys Ala Arg Cys 
                85                  90                  95


Arg Ile Glu Asn Cys Asp Ser Cys Phe Ser Lys Asp Phe Cys Thr Lys 
            100                 105                 110


Cys Lys Val Gly Phe Tyr Leu His Arg Gly Arg Cys Phe Asp Glu Cys 
        115                 120                 125


Pro Asp Gly Phe Ala Pro Leu Glu Glu Thr Met Glu Cys Val Glu Gly 
    130                 135                 140


Cys Glu Val Gly His Trp Ser Glu Trp Gly Thr Cys Ser Arg Asn Asn 
145                 150                 155                 160


Arg Thr Cys Gly Phe Lys Trp Gly Leu Glu Thr Arg Thr Arg Gln Ile 
                165                 170                 175


Val Lys Lys Pro Val Lys Asp Thr Ile Pro Cys Pro Thr Ile Ala Glu 
            180                 185                 190


Ser Arg Arg Cys Lys Met Thr Met Arg His Cys Pro Gly Gly Lys Arg 
        195                 200                 205


Thr Pro Lys Ala Lys Glu Lys Arg Asn Lys Lys Lys Lys Arg Lys Leu 
    210                 215                 220


Ile Glu Arg Ala Gln Glu Gln His Ser Val Phe Leu Ala Thr Asp Arg 
225                 230                 235                 240


Ala Asn Gln 



<210>  583
<211>  1773
<212>  DNA
<213>  Homo sapiens

<400>  583
tggctcctgg ggtgcagaga ggggccacag tctctgcggc tgtgtcacgc tcccctgcag     60

tcccctccat gttccctggc accactactc cccttcctaa ggccgccgct taccccaggg    120

tctatggaag taatgaagga cccctcaacc tggctcatca acagagcaga tgagcagacc    180

gtttattagc tgtaggcaaa tacgaagagg ctatttcttg tcacaaaaag gctgcagcgt    240

atctttctga agctatgaag ctgacacagt ctgagcaggc tcatctttca ctggaattgc    300

aaagggatag ccatatgaaa cagctcctcc tcatccaaga gagatggaaa agggcccagg    360

gtgaagcaag attgaaagcc cagcagaaca cagacaagga tgtagctgcc catcttcagg    420

catctcacaa accctctgta gaggatgcag agggccagag tcccctttct cagaagtaca    480

gcccttccac agagaaatgt ctgcctgaga ttcaggggat ctttgacagg gatccagaca    540

cactactata tttacttcag caaaagagtg agccagcaga gccatgtatt ggaagtaaag    600

ccccaaaaga cgataaaaca attatagagg agcaggcaac caaaattgca gatttgaaga    660

ggcatgtgga attccttgtg gcagagaatt aaagattaag ggaagaaaat aacaactaaa    720

ggctgaaaag gccagacttc taaaaggtcc aatagaaaag gagctggatg tagatgctga    780

ttttgtagaa acatcagagt tatggagctt gccaccacat tcagaaactg ctacagcctc    840

ctcaacctgg cagaagtttg cagcaaatac tgggaaagcc aaggacattc ctgtcttccg    900

cccttggatt ttccatctac agaacttcct cttatggagc tctctgagga tattctgaaa    960

ggatttatga ataattgaaa tagaaggcca ccaaaagggg aaaagaggaa ataatacagt   1020

aatcgttaat ccagcaaaaa gaaaagggaa aaccacatag aagggtcatc ccggaaatgc   1080

ttcatctggt ggactgtggg agcagaggca ttgccaggac ttgggaaaca gtcactgtga   1140

aatgcgcagc atatctcatt cactcacttg agctaatgat tctgacttgg cagacgctaa   1200

actcatggag gttcagtttc tcctgatcca aaccaaatgg ctacctggaa taatttcttc   1260

caagcaacag ttatttttct tatcttcagg tttaaaatgt ataaaagtta tgtgtaatta   1320

atctataatg ccataaatga taatgcaaaa cctaaataat atggtggccg gaggggctgc   1380

tttatatttg aaacatgctt tctatcatgc attaactgta tgcactttgt taatgcacat   1440

tttgtttgtt taaggtaaga tccacaccct tctagatgaa actatatgtg ccacactttg   1500

cactactcat aatgataacc tcaagactat cagaagaaat atttaaattt ccattttatg   1560

aagaaaggaa ccaaattatt atgctttttt aaacaaatta ccagtttaca taattaatca   1620

gggtgcgttt caagttctaa ctttgtttat tgtataatgc atcatttgaa aataccaagg   1680

aggaaatacc ctttgttttt aatgatgcaa gagtggaagt aatgctagtt ggtggtattt   1740

gattgtaaga aatcaataaa gtaattatgt ttt                                1773


<210>  584
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  584

Met Lys Leu Thr Gln Ser Glu Gln Ala His Leu Ser Leu Glu Leu Gln 
1               5                   10                  15


Arg Asp Ser His Met Lys Gln Leu Leu Leu Ile Gln Glu Arg Trp Lys 
            20                  25                  30


Arg Ala Gln Gly Glu Ala Arg Leu Lys Ala Gln Gln Asn Thr Asp Lys 
        35                  40                  45


Asp Val Ala Ala His Leu Gln Ala Ser His Lys Pro Ser Val Glu Asp 
    50                  55                  60


Ala Glu Gly Gln Ser Pro Leu Ser Gln Lys Tyr Ser Pro Ser Thr Glu 
65                  70                  75                  80


Lys Cys Leu Pro Glu Ile Gln Gly Ile Phe Asp Arg Asp Pro Asp Thr 
                85                  90                  95


Leu Leu Tyr Leu Leu Gln Gln Lys Ser Glu Pro Ala Glu Pro Cys Ile 
            100                 105                 110


Gly Ser Lys Ala Pro Lys Asp Asp Lys Thr Ile Ile Glu Glu Gln Ala 
        115                 120                 125


Thr Lys Ile Ala Asp Leu Lys Arg His Val Glu Phe Leu Val Ala Glu 
    130                 135                 140


Asn 
145


<210>  585
<211>  2277
<212>  DNA
<213>  Homo sapiens

<400>  585
actgccactc ttaactcttg aagtaaataa ataatctttg ctggcaggac tatgctgaat     60

ctccttaggc actctctaat tagatgtcct aggtcctccc aattcttagt ccttttatac    120

ctgtttttct ccttctctta ttccatttag tttttcaatt catacaaaac tgtatccagg    180

ccatcaccta tcattctata caacaaatgt ttcttctaac atccccacaa tatcacccct    240

taccacaaga cctcccttca gcttaatctc tcccactcta ggttcccacg ctgcccctaa    300

tcccgcttga agcagccctg agaaacatcg cccattctct ctccatacca ccccccaaaa    360

attttcgcca ccccaacact tcaacactat tttatttttc ttattaatat aagaaggcag    420

gcatgtcagg cctctgagcc caagccaagc catcgcaacc cctgtgactt gcacctatac    480

gcccagatgg cctgaagtaa ctgaagaatc acaaaagaag tgaatatgcc ctgccccacc    540

ttaactgatg acattccacc acaaaagaag tgtaaatggc tggtccttgc cttaactgat    600

gacattacct tgtgaaagtc ctcttcctgg ctcatcctgg ctcaaaaagc acccccactg    660

agcaccttga gacccccact cctgcccgcc agagaacaaa ccccctttga ctgtaatttt    720

cctttaccta cccaaatcct ataaaacggc cccaccctta tctcccttca ctgactctct    780

tttcggactc agcccgcctg cacccaggtg aaataaacag ctttattgct cacacaaagc    840

ctgtttggtg gtctcttcac acggacgcac atgaaattta gttgtatcca taaggcatat    900

ggaggagact aattcctctt ccaaagacat gtaccagagt cctggagagg ctgagggctg    960

gaggtggaag aaaggctctg acaggggtca gaatctgttc aggaaacata gcaaatgcct   1020

gatactttta attagagaaa ggtttgaatc tccacattca tatatttgca gtccagtgac   1080

ctttcagttt ttttatgccc aaagtgtcaa gcatgttaat gttaccattg actgcctccc   1140

tgaaggtgca gctaccaggg gaactgccag gacttcaaag cccacaacca aaagccagaa   1200

aacactacca agtacaagcc ccggacactg gacccagagc acaccctggg catctgctct   1260

gagatcctct ccctggacag agacagctgc tccttcagaa acagaggaga ccctgaacac   1320

aggcaggcct cctgagcttc cagccagggc cacagccaca tggttcagtg cctcccacac   1380

tctcccagcc ttggctacca ggagggtggc cagaactcag tggttgacag ctgacagaca   1440

gacgtgggct tccatatcgt ccgtgccctg ggctcagacc atcagtgaga aaaaacctgg   1500

agggtctctc tgggaaactc gttcttcccc accgactact gcagggaccg aggaagccat   1560

gaacactaca agccttttgg cgcctgctgc tgagataatg gccacacctg gcagcccatc   1620

ccaggccagc cctaccttgg gagcattcac ccatggcaca cagactccga gtccaaccaa   1680

ggcaacagcc cccagatatc cacaaacagg tgatctctct gcagagtggc cattcactgc   1740

tggtgaagag ccagtcctgg tcccaagacc ccatcaagtt tcaaggtgtc ctcagccact   1800

cttcaaggtg ggagctatgg cagctgctcc tctcaccctg gctattcaga ggctcaaccc   1860

atgcctgatg gagctgtgcc aattcttcca gcaatgcctc tgcatgagcc agaggagtcc   1920

caggacagag gacatgagat actgtcttga atactattcc tggtttctga agaatgcaac   1980

atatatctgt cagagggtga aaagggtgtc ccactcgcac accttaaagc aaaagtgcct   2040

tgagaatatc tgcaagtctg tgtgaggcct tgaaaataac actagggcat aacaattact   2100

tcaggggata cgccatccac cctggctctt gtcccaagtg ggctacattt gaagaattca   2160

cccaggctcc agctagatca tcagttaatt taaagtggtt attcttggaa gtagcatttt   2220

ttttccctct cctgtgaatc tgtgcaaaac attgaaggta gaagttttct tgttaga      2277


<210>  586
<211>  3097
<212>  DNA
<213>  Homo sapiens

<400>  586
gacccgcgcg ggatgtgacc ccctgacccc ctgcctggcc tcccctgccc cccagggggc     60

ccgcctttgc ctgcttttgg gggggggtgg ggaggggcgc gcggatcatg gcattggagt    120

tcccgggctt gcagccgccg ccgccgcctc gttcacgcac cccgagcgcc ccttcttccc    180

agagcagcag cggagaaggc gaagcggccg gcgggggcga ggcagatggg gctcaaggcg    240

cgcagggcgg cgggggcggc tggcggcggc ggcgacgggg gcggcggagg cggcggggcg    300

gctaacccag ccggagggga cgcggcggcg gccggcgacg aggagcggaa agtggggctg    360

gcgcccggcg acgtggagca agtcaccttg gcgctcgggg ccggagccga caaagacggg    420

accctgctgc tggagggcgg cggccgcgac gaggggcagc ggaggacccc gcagggcatc    480

gggctcctgg ccaagacccc gctgagccgc ccagtcaaga gaaacaacgc caagtaccgg    540

cgcatccaaa ctttgatcta cgacgccctg gagagaccgc ggggctgggc gctgctttac    600

cacgcgttgg tgttcctgat tgtcctgggg tgcttgattc tggctgtcct gaccacattc    660

aaggagtatg agactgtctc gggagactgg cttctgttac tggagacatt tgctattttc    720

atctttggag ccgagtttgc tttgaggatc tgggctgctg gatgttgctg ccgatacaaa    780

ggctggcggg gccgactgaa gtttgccagg aagcccctgt gcatgttgga catctttgtg    840

ctgattgcct ctgtgccagt ggttgctgtg ggaaaccaag gcaatgttct ggccacctcc    900

ctgcgaagcc tgcgcttcct gcagatcctg cgcatgctgc ggatggaccg gagaggtggc    960

acctggaagc ttctgggctc agccatctgt gcccacagca aagaactcat cacggcctgg   1020

tacatcggtt tcctgacact catcctttct tcatttcttg tctacctggt tgagaaagac   1080

gtcccagagg tggatgcaca aggagaggag atgaaagagg agtttgagac ctatgcagat   1140

gccctgtggt ggggcctgat cacactggcc accattggct atggagacaa gacacccaaa   1200

acgtgggaag gccgtctgat tgccgccacc ttttccttaa ttggcgtctc cttttttgcc   1260

cttccagcgg gcatcctggg gtccgggctg gccctcaagg tgcaggagca acaccgtcag   1320

aagcactttg agaaaaggag gaagccagct gctgagctca ttcaggctgc ctggaggtat   1380

tatgctacca accccaacag gattgacctg gtggcgacat ggagatttta tgaatcagtc   1440

gtctcttttc ctttcttcag gaaagaacag ctggaggcag catccagcca aaagctgggt   1500

ctcttggatc gggttcgcct ttctaatcct cgtggtagca atactaaagg aaagctattt   1560

acccctctga atgtagatgc catagaagaa agtccttcta aagaaccaaa gcctgttggc   1620

ttaaacaata aagagcgttt ccgcacggcc ttccgcatga aagcctacgc tttctggcag   1680

agttctgaag atgccgggac aggtgacccc atggcggaag acaggggcta tgggaatgac   1740

ttccccatcg aagacatgat ccccaccctg aaggccgcca tccgagccgt cagaattcta   1800

caattccgtc tctataaaaa aaaattcaag gagactttga ggccttacga tgtgaaggat   1860

gtgattgagc agtattctgc cgggcatctc gacatgcttt ccaggataaa gtaccttcag   1920

acgagaatag atatgatttt cacccctgga cctccctcca cgccaaaaca caagaagtct   1980

cagaaagggt cagcattcac cttcccatcc cagcaatctc ccaggaatga accatatgta   2040

gccagaccat ccacatcaga aatcgaagac caaagcatga tggggaagtt tgtaaaagtt   2100

gaaagacagg ttcaggacat ggggaagaag ctggacttcc tcgtggatat gcacatgcaa   2160

cacatggaac ggttgcaggt gcaggtcacg gagtattacc caaccaaggg cacctcctcg   2220

ccagctgaag cagagaagaa ggaggacaac aggtattccg atttgaaaac catcatctgc   2280

aactattctg agacaggccc cccggaacca ccctacagct tccaccaggt gaccattgac   2340

aaagtcagcc cctatgggtt ttttgcacat gaccctgtga acctgccccg agggggaccc   2400

agttctggaa aggttcaggc aactcctcct tcctcagcaa caacgtatgt ggagaggccc   2460

acggtcctgc ctatcttgac tcttctcgac tcccgagtga gctgccactc ccaggctgac   2520

ctgcagggcc cctactcgga ccgaatctcc ccccggcaga gacgtagcat cacgcgagac   2580

agtgacacac ctctgtccct gatgtcggtc aaccacgagg agctggagag gtctccaagt   2640

ggcttcagca tctcccagga cagagatgat tatgtgttcg gccccaatgg ggggtcgagc   2700

tggatgaggg agaagcggta cctcgccgag ggtgagacgg acacagacac ggaccccttc   2760

acgcccagcg gctccatgcc tctgtcgtcc acaggggatg ggatttctga ttcagtatgg   2820

accccttcca ataagcccat ttaaaagagg tcactggctg acccctcctt gtaatgtaga   2880

cagactttgt atagttcact tactcttaca cccgacgctt accagcgggg acaccaatgg   2940

ctgcatcaaa tgcatgcgtg tgcgtggtgg ccccacccag gcaggggctt cccacagcct   3000

cttcctcccc atgtcaccac aacaaagtgc ttccttttca gcatggtttg catgacttta   3060

cactatataa atggttccgc taatctcttc taggata                            3097


<210>  587
<211>  872
<212>  PRT
<213>  Homo sapiens

<400>  587

Met Gly Leu Lys Ala Arg Arg Ala Ala Gly Ala Ala Gly Gly Gly Gly 
1               5                   10                  15


Asp Gly Gly Gly Gly Gly Gly Gly Ala Ala Asn Pro Ala Gly Gly Asp 
            20                  25                  30


Ala Ala Ala Ala Gly Asp Glu Glu Arg Lys Val Gly Leu Ala Pro Gly 
        35                  40                  45


Asp Val Glu Gln Val Thr Leu Ala Leu Gly Ala Gly Ala Asp Lys Asp 
    50                  55                  60


Gly Thr Leu Leu Leu Glu Gly Gly Gly Arg Asp Glu Gly Gln Arg Arg 
65                  70                  75                  80


Thr Pro Gln Gly Ile Gly Leu Leu Ala Lys Thr Pro Leu Ser Arg Pro 
                85                  90                  95


Val Lys Arg Asn Asn Ala Lys Tyr Arg Arg Ile Gln Thr Leu Ile Tyr 
            100                 105                 110


Asp Ala Leu Glu Arg Pro Arg Gly Trp Ala Leu Leu Tyr His Ala Leu 
        115                 120                 125


Val Phe Leu Ile Val Leu Gly Cys Leu Ile Leu Ala Val Leu Thr Thr 
    130                 135                 140


Phe Lys Glu Tyr Glu Thr Val Ser Gly Asp Trp Leu Leu Leu Leu Glu 
145                 150                 155                 160


Thr Phe Ala Ile Phe Ile Phe Gly Ala Glu Phe Ala Leu Arg Ile Trp 
                165                 170                 175


Ala Ala Gly Cys Cys Cys Arg Tyr Lys Gly Trp Arg Gly Arg Leu Lys 
            180                 185                 190


Phe Ala Arg Lys Pro Leu Cys Met Leu Asp Ile Phe Val Leu Ile Ala 
        195                 200                 205


Ser Val Pro Val Val Ala Val Gly Asn Gln Gly Asn Val Leu Ala Thr 
    210                 215                 220


Ser Leu Arg Ser Leu Arg Phe Leu Gln Ile Leu Arg Met Leu Arg Met 
225                 230                 235                 240


Asp Arg Arg Gly Gly Thr Trp Lys Leu Leu Gly Ser Ala Ile Cys Ala 
                245                 250                 255


His Ser Lys Glu Leu Ile Thr Ala Trp Tyr Ile Gly Phe Leu Thr Leu 
            260                 265                 270


Ile Leu Ser Ser Phe Leu Val Tyr Leu Val Glu Lys Asp Val Pro Glu 
        275                 280                 285


Val Asp Ala Gln Gly Glu Glu Met Lys Glu Glu Phe Glu Thr Tyr Ala 
    290                 295                 300


Asp Ala Leu Trp Trp Gly Leu Ile Thr Leu Ala Thr Ile Gly Tyr Gly 
305                 310                 315                 320


Asp Lys Thr Pro Lys Thr Trp Glu Gly Arg Leu Ile Ala Ala Thr Phe 
                325                 330                 335


Ser Leu Ile Gly Val Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly 
            340                 345                 350


Ser Gly Leu Ala Leu Lys Val Gln Glu Gln His Arg Gln Lys His Phe 
        355                 360                 365


Glu Lys Arg Arg Lys Pro Ala Ala Glu Leu Ile Gln Ala Ala Trp Arg 
    370                 375                 380


Tyr Tyr Ala Thr Asn Pro Asn Arg Ile Asp Leu Val Ala Thr Trp Arg 
385                 390                 395                 400


Phe Tyr Glu Ser Val Val Ser Phe Pro Phe Phe Arg Lys Glu Gln Leu 
                405                 410                 415


Glu Ala Ala Ser Ser Gln Lys Leu Gly Leu Leu Asp Arg Val Arg Leu 
            420                 425                 430


Ser Asn Pro Arg Gly Ser Asn Thr Lys Gly Lys Leu Phe Thr Pro Leu 
        435                 440                 445


Asn Val Asp Ala Ile Glu Glu Ser Pro Ser Lys Glu Pro Lys Pro Val 
    450                 455                 460


Gly Leu Asn Asn Lys Glu Arg Phe Arg Thr Ala Phe Arg Met Lys Ala 
465                 470                 475                 480


Tyr Ala Phe Trp Gln Ser Ser Glu Asp Ala Gly Thr Gly Asp Pro Met 
                485                 490                 495


Ala Glu Asp Arg Gly Tyr Gly Asn Asp Phe Pro Ile Glu Asp Met Ile 
            500                 505                 510


Pro Thr Leu Lys Ala Ala Ile Arg Ala Val Arg Ile Leu Gln Phe Arg 
        515                 520                 525


Leu Tyr Lys Lys Lys Phe Lys Glu Thr Leu Arg Pro Tyr Asp Val Lys 
    530                 535                 540


Asp Val Ile Glu Gln Tyr Ser Ala Gly His Leu Asp Met Leu Ser Arg 
545                 550                 555                 560


Ile Lys Tyr Leu Gln Thr Arg Ile Asp Met Ile Phe Thr Pro Gly Pro 
                565                 570                 575


Pro Ser Thr Pro Lys His Lys Lys Ser Gln Lys Gly Ser Ala Phe Thr 
            580                 585                 590


Phe Pro Ser Gln Gln Ser Pro Arg Asn Glu Pro Tyr Val Ala Arg Pro 
        595                 600                 605


Ser Thr Ser Glu Ile Glu Asp Gln Ser Met Met Gly Lys Phe Val Lys 
    610                 615                 620


Val Glu Arg Gln Val Gln Asp Met Gly Lys Lys Leu Asp Phe Leu Val 
625                 630                 635                 640


Asp Met His Met Gln His Met Glu Arg Leu Gln Val Gln Val Thr Glu 
                645                 650                 655


Tyr Tyr Pro Thr Lys Gly Thr Ser Ser Pro Ala Glu Ala Glu Lys Lys 
            660                 665                 670


Glu Asp Asn Arg Tyr Ser Asp Leu Lys Thr Ile Ile Cys Asn Tyr Ser 
        675                 680                 685


Glu Thr Gly Pro Pro Glu Pro Pro Tyr Ser Phe His Gln Val Thr Ile 
    690                 695                 700


Asp Lys Val Ser Pro Tyr Gly Phe Phe Ala His Asp Pro Val Asn Leu 
705                 710                 715                 720


Pro Arg Gly Gly Pro Ser Ser Gly Lys Val Gln Ala Thr Pro Pro Ser 
                725                 730                 735


Ser Ala Thr Thr Tyr Val Glu Arg Pro Thr Val Leu Pro Ile Leu Thr 
            740                 745                 750


Leu Leu Asp Ser Arg Val Ser Cys His Ser Gln Ala Asp Leu Gln Gly 
        755                 760                 765


Pro Tyr Ser Asp Arg Ile Ser Pro Arg Gln Arg Arg Ser Ile Thr Arg 
    770                 775                 780


Asp Ser Asp Thr Pro Leu Ser Leu Met Ser Val Asn His Glu Glu Leu 
785                 790                 795                 800


Glu Arg Ser Pro Ser Gly Phe Ser Ile Ser Gln Asp Arg Asp Asp Tyr 
                805                 810                 815


Val Phe Gly Pro Asn Gly Gly Ser Ser Trp Met Arg Glu Lys Arg Tyr 
            820                 825                 830


Leu Ala Glu Gly Glu Thr Asp Thr Asp Thr Asp Pro Phe Thr Pro Ser 
        835                 840                 845


Gly Ser Met Pro Leu Ser Ser Thr Gly Asp Gly Ile Ser Asp Ser Val 
    850                 855                 860


Trp Thr Pro Ser Asn Lys Pro Ile 
865                 870


<210>  588
<211>  10078
<212>  DNA
<213>  Homo sapiens

<400>  588
gcagtttatt ctgggcctgt gtggaataga aagacaattc tttatttgac tggtaggaaa     60

gaaaagagaa gactcctcag ggtttccaag gaggactgga gcggctgctt tagtgaagaa    120

gtgaagaatc aaggaagtaa aggacctgtc tcaaagtcac acaactagga aatcttgagg    180

agtctgatac ttttcatcct ccagctataa aatcatcttg tagggggaag ctgtacattg    240

gtggaaaata aaaggcaagc agttcctggc ccgtgatatt ccagttagag gtgtctgact    300

gacagcatgt tggcaccgag ggaagcgatg ggcttcggct ccaggtttct gtcctgagac    360

cacagcagaa tgtgccttgg acaaaggctt ggactccttg atcttctggt aacttcaaaa    420

atctggtctc agggtggtga actttttctt cgaattccta acctgtgagc ttacgatgat    480

ggtgcctgtc cattaactga acaactgtgg ttttgaactt cttgaggcca gggactgtgt    540

ctgaaaacac cgacggtggc taactcaagg gagacgtctg gtgaacaccc gtgggatcta    600

aagaacaagc tctgaaagtg ttccagctga aatttcagat cggacagact cgctgcggct    660

ccggaggcag tgattccaag ctgctcgcgc acgctgctgc caagctgcag gatggtgcac    720

gtagccaggc tgctgctgct gctcctcact ttcttcctcc gcacggatgc tgagacacct    780

ccaaggttta cacgaacacc cgttgatcag acaggggtct ctggcggagt tgcctctttc    840

atctgccaag ctacgggaga cccaagacct aaaattgtct ggaacaaaaa aggaaagaaa    900

gtcagcaatc agagatttga ggtaatagag tttgacgatg ggtctggatc agttctcaga    960

atacaaccct tacggactcc gagggatgag gccatttatg aatgtgtggc ctcaaataat   1020

gtgggagaaa taagtgtatc caccagactc acagttttgc gggaagatca aattcccagg   1080

ggcttcccta ccattgacat gggcccacag ttgaaggtgg ttgagcgtac tcgcacggcc   1140

accatgcttt gtgcagccag tggtaatccg gatccagaaa tcacttggtt taaagatttc   1200

ttacctgtgg acacaagcaa caacaatggt cgtattaagc agttacgatc agaatctatt   1260

ggtggtacac caataagagg agcccttcag attgagcaga gtgaagagtc tgaccaagga   1320

aaatatgagt gtgttgccac caacagcgcg ggcactcgct attccgctcc tgccaattta   1380

tatgtcagag agctgcgaga agttcgccgt gtcccaccaa gattctctat cccacccact   1440

aatcatgaaa tcatgccagg cggaagcgtt aatatcacct gtgtggccgt ggggtcacca   1500

atgccttatg taaagtggat gttgggggca gaagatctga cacctgaaga tgatatgcca   1560

ataggaagaa atgtgctaga actgaatgat gtaagacagt cagcaaatta cacctgtgtt   1620

gctatgtcaa cactgggtgt cattgaagca atagcacaga tcactgtcaa agccttaccc   1680

aaacctccag gaactcctgt agtgaccgag agcacagcta caagcatcac actgacgtgg   1740

gactctggga accctgagcc tgtttcttat tacataattc agcataaacc taaaaactct   1800

gaggaacttt acaaagaaat tgatggggtg gcgaccacac gctacagtgt cgctggacta   1860

agtccctact cggattatga attcagggtt gttgctgtca ataacattgg gcgggggcct   1920

cccagcgaac ctgtgctaac acaaacctca gagcaagcac catccagtgc cccgagggat   1980

gtccaggcac gaatgttgag ttcgaccacc attttggtac agtggaagga acctgaagag   2040

ccaaatggac agatccaagg atatagagtt tattatacaa tggatcccac tcaacatgtc   2100

aacaactgga tgaaacacaa tgtagctgac agccaaatca ctactattgg caacttagtg   2160

ccccagaaaa catattctgt caaagtcctg gcttttacct caattggaga tggtcccctt   2220

tcaagtgaca tacaagtcat cactcagaca ggagtaccag ggcagccact aaacttcaaa   2280

gcagaacctg agtctgaaac aagtattttg ctctcttgga cacctccacg ttcagatacc   2340

attgccaact atgaactggt ctacaaagat ggggagcatg gagaggagca acgaattacc   2400

attgagccag ggacatcata taggctgcaa ggactgaaac caaacagctt atactatttc   2460

cgtctggctg cacgctcccc tcaaggcctg ggtgcttcta ctgcagaaat atcagctaga   2520

accatgcagt caaagccgtc agctcctcct caagacatta gttgcaccag cccaagttcc   2580

actagtattt tggtaagttg gcaacctcca ccagtggaaa aacagaatgg cattatcact   2640

gaatactcca tcaagtacac tgcagtggat ggggaagatg acaagcctca cgagattttg   2700

ggaattcctt cggacactac caaatacctt ttggaacagc tggaaaaatg gactgaatac   2760

cggatcactg tgacagccca tacagatgtc ggccctggcc ctgagagctt gtccgtgttg   2820

attcgaacca atgaagatgt tcctagtggt cctcctcgca aagtcgaggt agaggctgtc   2880

aactcaacat ctgttaaagt ctcatggcgc tcacccgtgc ccaataaaca gcatggccag   2940

ataagaggat atcaggtgca ttatgtgagg atggaaaatg gtgagcccaa gggccagccc   3000

atgctgaaag atgtcatgct ggctgatgca cagtgggaat ttgatgatac tactgaacat   3060

gacatgatca tttctgggct ccagcctgaa acttcctact ccctcaccgt cacagcctac   3120

acaaccaaag gagatggtgc tcgcagcaag cccaaactgg tgtccaccac tggggcagtt   3180

ccagggaaac ctcggcttgt gattaaccac actcagatga atactgctct tattcagtgg   3240

caccctccgg tggacacatt tggacctctt cagggctacc gtctaaaatt tggccgcaag   3300

gatatggagc cacttactac tcttgagttc tctgaaaaag aagatcactt tacagctaca   3360

gacatccaca agggagcatc atacgtcttc aggctctcag ccagaaacaa agtgggcttt   3420

ggggaggaga tggtgaagga gatttccatt ccagaagaag taccaactgg attccctcaa   3480

aaccttcact cagaaggcac cacttcaacc tccgtccagt tatcttggca accacctgtc   3540

ctggcagaga gaaatggcat tatcaccaag tatacccttc tttataggga tatcaacatc   3600

ccccttctcc cgatggagca gcttattgtt ccagctgaca ccactatgac actcactggc   3660

ttaaaaccag ataccacata cgatgtaaaa gtacgtgctc atacgagcaa agggcccggg   3720

ccatatagtc ccagtgtcca gttcaggaca ctgcctgtgg atcaagtgtt tgcaaaaaat   3780

tttcatgtca aagcagtaat gaagacttcc gtgttgctgt cttgggagat tccagagaat   3840

tataactccg ccatgccttt caaaattctt tatgatgatg ggaaaatggt agaagaagtg   3900

gatggccgag ccacacagaa gttaattgtc aacctgaagc ctgagaaatc atattcattt   3960

gtgctgacaa atcgtggaaa cagtgctggt gggctgcagc acagggtcac ggcaaagact   4020

gcaccagatg tattacgtac caagcctgcc ttcattggga agaccaactt ggatggcatg   4080

attactgtgc aactgcctga agtacctgca aatgagaata taaaaggtta ctacataata   4140

attgtgcctt tgaagaaatc tcgcgggaaa tttatcaagc catgggagag tccagatgaa   4200

atggaattag atgagctgct taaggagata tctaggaagc gcagaagcat ccgttatggg   4260

agagaagttg aattaaagcc atatattgcc gctcactttg atgtccttcc cactgagttc   4320

accctggggg atgacaagca ttatggtgga tttacaaaca agcaactcca aagtggtcaa   4380

gaatatgtct tctttgtgtt agcagtaatg gaacatgcag agtctaagat gtatgcaacc   4440

agcccttact ccgaccccgt ggtgtcaatg gatctggatc cgcagccaat cacggatgaa   4500

gaagaaggct tgatctgggt tgtaggtcct gtccttgcag tggtctttat catctgcatt   4560

gtcattgcta ttcttcttta taaaaggaag agggcagagt ccgactctag aaaaagcagc   4620

ataccgaaca ataaggagat cccttcacac cacccaacag accctgtaga actgaggcgc   4680

cttaactttc aaacaccggg tatggctagc catcctccaa tacccatctt ggaacttgca   4740

gaccacattg aaagattgaa agcaaatgac aacttgaagt tttcccagga atatgagtca   4800

attgaccctg gccagcagtt cacttgggaa cattcaaact tggaagtaaa caaaccaaag   4860

aatagatacg cgaatgtaat cgcatatgat cattcccggg ttctcctatc agctatagaa   4920

gggatcccag gaagtgacta tgtgaatgcc aactacatag atgggtatag gaagcaaaat   4980

gcctatattg caacacaggg atctctcccc gaaacatttg gggacttttg gagaatgata   5040

tgggaacaac ggagtgccac agttgtcatg atgacaaaac tagaagaaag atcaagggtg   5100

aagtgtgacc agtattggcc tagcagaggc acagaaaccc acggactcgt tcaagtaacg   5160

ctgcttgata ctgtggagct ggccacatat tgtgttcgaa catttgcact ttacaagaat   5220

ggttcaagtg agaagagaga agtgagacaa ttccagttca ccgcctggcc tgatcatggt   5280

gttccagaac accctacacc ttttctagct ttcttacgta gagtcaaaac ctgtaaccct   5340

cccgatgctg gtccgatggt tgtgcactgc agtgcgggag ttggccggac tggttgcttc   5400

atcgtcatag atgccatgtt agaaagaata aagcatgaaa aaactgtaga tatttatggc   5460

catgtaactt taatgagagc ccagaggaac tatatggttc aaacagaaga ccaatacatc   5520

tttatccatg atgcactgtt agaagcagtg acttgtggaa ataccgaagt gccagctaga   5580

aacttgtatg cctacattca gaagctgaca caaatagaaa cgggagagaa tgtcacagga   5640

atggagctcg aatttaagcg tctagccagc tcaaaagctc acacctcaag gtttatcagt   5700

gccaatcttc catgtaataa attcaaaaat cgccttgtta atattatgcc atatgaatcc   5760

acaagggtat gcctgcagcc tatccgtgga gtagaaggat ctgattacat caatgccagt   5820

tttattgatg gatacagaca acagaaagcc tacatcgcta cccaggggcc cttggcagag   5880

accactgaag acttctggcg gatgctctgg gaacacaatt ccaccatagt tgtgatgctc   5940

accaagctgc gtgaaatggg cagagagaaa tgtcaccaat actggccagc agaacggtct   6000

gcaagatacc agtactttgt tgtagatccc atggctgagt acaacatgcc acagtatatc   6060

ctaagggaat tcaaggtcac agatgccagg gacggccagt cccgaacagt aaggcagttc   6120

cagttcactg actggccaga gcaaggagtg ccaaagtccg gagaaggatt tattgacttc   6180

atcggccaag tccataaaac aaaagaacag tttggccaag atggacccat ttcagtccat   6240

tgcagcgcgg gcgttggaag aactggagtc ttcataacgc taagcattgt tttggaaaga   6300

atgagatatg aaggagttgt agatatcttc cagactgtca aaatgttaag aacacaacga   6360

ccagctatgg tacagacaga ggatcaatat cagttttcct atcgtgccgc actagagtac   6420

ctgggcagct ttgaccacta tgcaacgtag aaacccctga cccattctgg atttttacta   6480

caggcccttc aatatccatg gagtctcttc tgagccatac agggcacttg agaagtcctt   6540

cttaacttct agctaacaac tacttagtgg gactattaca cacaaaacaa attaaaaaca   6600

aattattcca ggtggaccaa gaattcacag tttaataatc taacctgaaa aataatgaag   6660

agaatcctga ctgatgaggc atctgaagga ttttatttac agatacctca aggattcaaa   6720

atcaagggaa gaagaaatca cagcaaagaa ccaccatctt attcaggatt gcttgaaagg   6780

tgcaaggaga aattgccaga atgctgcagt tcagcacaag atatgtgctg gtgtggcttc   6840

tcacaatgaa acggactctg ctttgacatc gccccttccc accatactgc tcataataac   6900

attttagggg gaaaggggag ggaatgttta aaaagaaagt ccttgattta gttttttagt   6960

attgtaaaga tactgctgac ctgtgcttca tttctaactg tgtaaacttt tttttaacaa   7020

aatgtatcat tcgataaagt gaattttaaa aaagttacat aactcttcat ttttttattt   7080

ccaaatcgta ggttttttta agctgtagaa ctgttatctg taatatcttg ctgtagaaat   7140

atcaaatcat ttgaaaattt gcacattttt gtgcaaaact caatctacag tatcagtctc   7200

gtcagatata ttaattttac acttcagttt tgattggtga gaaagtaccc attctcttca   7260

aataatcaaa gataattatt attttgtttt gtttttggaa tcaacaggga ggcgcaaagt   7320

ataaagttgc tgctaacata tatacatata tatccatatt ttataagggt gtctatgtat   7380

atatagacag tgtgtccaca caaaaaatag atacagttat cagtcagtca gttcttccat   7440

gatttagttt ttttaaacgt agaaaagcta ttgtaaacat ctctttccat ttattcttaa   7500

ttttttgaca tattggtatt tctttaaagg gaaatgagga atgcacatca gtgattgatt   7560

gtcaaacctc accccctgat ttcctaccta atctaccccc acctaaccaa tcaatcacat   7620

ccacaaattg ttttgtttgt ttgttagtca ggcttccaac aaagttcaat atttctaaca   7680

ctctagtgca ataaaaatta ttattaaata gctaagaggt gtgcatgtgg gaaaggtcag   7740

tgcatatccc tttaggaggg gagaatgttg taatatatca gctatcgagt tgtttaaaaa   7800

aagtgtattc aatcgtatat tgtctatagt atgtgctatg aaatttgcat ttatgatatg   7860

taacaggggc aaagccaaat tcatgttact ctgttcagtc agaaacattt tgtggcatac   7920

agcattcctg ggaagtgctg tactttgttt cgttttggtt ttagttttgc atttagagtg   7980

ccttataatt gatgcctatt ttaatagcat ttctttttag cttttggttc gtatttccat   8040

tcactgttcg tatctgttac tttctattaa agcattatct gtttaccaca tgtacaaaaa   8100

ctctttgaat aatatgcatt cctagttttc agccaagtcg gggatgttag tgattgtacc   8160

agcccaaagc acttggataa tcagggccct tcttcctttt ataatcaatc atcaacatca   8220

gaaaaagcta cttgttttat ttatattccc ttccaaatcc gctctggaac atgcagtaac   8280

tgcaccaaac ttattttagt aacaaatatc attggcaact ttggaatata tttgatattc   8340

cattaggatt tttctaaaag gggaaataaa ctatatatat atatgtatct tacccccaat   8400

tcttccaaca gaatttctat aggaagccat ggatgatggc ataagtttgc cacatattac   8460

atgattttaa ataatcctca aaatacccaa ggaactctta aagagttttg gtatgagtat   8520

actactttgg tttaatttta gcttcatgga tgttctgcat ggaaggattt ttgttttcca   8580

cattttccca ttgctagcag agtgaaatcc aagagaccaa acatttgcaa gcattgtatt   8640

tgagcacttt tgtaaaaaac aaagaaaaag aaaaaaaaga aaatatatat aatactaaaa   8700

aaaagtatct agaaggctac ctcagaatga gactctctaa cctacatcag aaccagagaa   8760

gaatgtgcac tatgtgggtc tgttatcatt attttctttt agtttgtatc tttttggaga   8820

tttatccaag tgccagatta ctcagtgcta taattttctt ttagttaaac aaagggggtc   8880

agacagacat tgcatcatcc agacatgcct tgttggacat gtagaatccg atggagcact   8940

gcacaccaga atgattggcc aatgagcagc ttctctccct gaaacaataa ctgcccattt   9000

ggcaaaggga aagatgacaa taatcagaag aagaaaatga atgggatgca taccatagac   9060

gaacgaggcg gagactattg cgggaatctt actgttcagg agctgttcct agaactaact   9120

cccttactgt cattgatgtg cattccactc tgtgcttttc tgtacaacca ttcaagtttt   9180

aatttcccag gtgaaccatc tttatctgcc attaccacaa gctttcaagt ttccagttat   9240

tttcatcatc ataaccagta cggtgctatt atttacctat gtacgtgtag ttatgtataa   9300

ttttgtaatt agttacaatg gtaaaaaaaa tcaaaatata taaaaagtga tttgtacaga   9360

actttatttt agctcttttt taaaaatgat ttgcatggtt agaaaacggc gaggacagcc   9420

aggggaggga agggcctcta gggaactttg cactttctat acctttgtac tatgcactgc   9480

cctattgatt ctacacccaa taatgatatt acttgaaccc atctgtaaga aactgcttcg   9540

gaaattcatt tgtgtgtatg taaataacac aacatagaaa caggaaggga aaaaagtctg   9600

cagtaatgca cgtatttttt ttctttcctg tttattttcg gttttgcttt aagtcctttt   9660

atttttaatt ccctttttgt ttttcttttt gggttttggt tccttttggg tttatgggtg   9720

ccctgatact ccagcagaga tcagaaggct acagatccat tctatccatc cgttatgtgg   9780

ctttgccatc ccagcttgga gtgtctttac aaagataata acagttgtgt tctttgctct   9840

cgttttggat gcatagactg aaaaattaaa acaaataact tgtaaaatgg cttgttaaaa   9900

aatacaatta cctctaatta gtagtacgcg taaatgtttt acagaatgaa aggcgtgctt   9960

tttattttct tacttcgtta cattggtggc gaaagaagtc tgtatgaaaa tcagttcttt  10020

gctgacacaa gttccatttg ttacaaatga attctaataa aaatgtcagt gttatgca    10078


<210>  589
<211>  1912
<212>  PRT
<213>  Homo sapiens

<400>  589

Met Val His Val Ala Arg Leu Leu Leu Leu Leu Leu Thr Phe Phe Leu 
1               5                   10                  15


Arg Thr Asp Ala Glu Thr Pro Pro Arg Phe Thr Arg Thr Pro Val Asp 
            20                  25                  30


Gln Thr Gly Val Ser Gly Gly Val Ala Ser Phe Ile Cys Gln Ala Thr 
        35                  40                  45


Gly Asp Pro Arg Pro Lys Ile Val Trp Asn Lys Lys Gly Lys Lys Val 
    50                  55                  60


Ser Asn Gln Arg Phe Glu Val Ile Glu Phe Asp Asp Gly Ser Gly Ser 
65                  70                  75                  80


Val Leu Arg Ile Gln Pro Leu Arg Thr Pro Arg Asp Glu Ala Ile Tyr 
                85                  90                  95


Glu Cys Val Ala Ser Asn Asn Val Gly Glu Ile Ser Val Ser Thr Arg 
            100                 105                 110


Leu Thr Val Leu Arg Glu Asp Gln Ile Pro Arg Gly Phe Pro Thr Ile 
        115                 120                 125


Asp Met Gly Pro Gln Leu Lys Val Val Glu Arg Thr Arg Thr Ala Thr 
    130                 135                 140


Met Leu Cys Ala Ala Ser Gly Asn Pro Asp Pro Glu Ile Thr Trp Phe 
145                 150                 155                 160


Lys Asp Phe Leu Pro Val Asp Thr Ser Asn Asn Asn Gly Arg Ile Lys 
                165                 170                 175


Gln Leu Arg Ser Glu Ser Ile Gly Gly Thr Pro Ile Arg Gly Ala Leu 
            180                 185                 190


Gln Ile Glu Gln Ser Glu Glu Ser Asp Gln Gly Lys Tyr Glu Cys Val 
        195                 200                 205


Ala Thr Asn Ser Ala Gly Thr Arg Tyr Ser Ala Pro Ala Asn Leu Tyr 
    210                 215                 220


Val Arg Glu Leu Arg Glu Val Arg Arg Val Pro Pro Arg Phe Ser Ile 
225                 230                 235                 240


Pro Pro Thr Asn His Glu Ile Met Pro Gly Gly Ser Val Asn Ile Thr 
                245                 250                 255


Cys Val Ala Val Gly Ser Pro Met Pro Tyr Val Lys Trp Met Leu Gly 
            260                 265                 270


Ala Glu Asp Leu Thr Pro Glu Asp Asp Met Pro Ile Gly Arg Asn Val 
        275                 280                 285


Leu Glu Leu Asn Asp Val Arg Gln Ser Ala Asn Tyr Thr Cys Val Ala 
    290                 295                 300


Met Ser Thr Leu Gly Val Ile Glu Ala Ile Ala Gln Ile Thr Val Lys 
305                 310                 315                 320


Ala Leu Pro Lys Pro Pro Gly Thr Pro Val Val Thr Glu Ser Thr Ala 
                325                 330                 335


Thr Ser Ile Thr Leu Thr Trp Asp Ser Gly Asn Pro Glu Pro Val Ser 
            340                 345                 350


Tyr Tyr Ile Ile Gln His Lys Pro Lys Asn Ser Glu Glu Leu Tyr Lys 
        355                 360                 365


Glu Ile Asp Gly Val Ala Thr Thr Arg Tyr Ser Val Ala Gly Leu Ser 
    370                 375                 380


Pro Tyr Ser Asp Tyr Glu Phe Arg Val Val Ala Val Asn Asn Ile Gly 
385                 390                 395                 400


Arg Gly Pro Pro Ser Glu Pro Val Leu Thr Gln Thr Ser Glu Gln Ala 
                405                 410                 415


Pro Ser Ser Ala Pro Arg Asp Val Gln Ala Arg Met Leu Ser Ser Thr 
            420                 425                 430


Thr Ile Leu Val Gln Trp Lys Glu Pro Glu Glu Pro Asn Gly Gln Ile 
        435                 440                 445


Gln Gly Tyr Arg Val Tyr Tyr Thr Met Asp Pro Thr Gln His Val Asn 
    450                 455                 460


Asn Trp Met Lys His Asn Val Ala Asp Ser Gln Ile Thr Thr Ile Gly 
465                 470                 475                 480


Asn Leu Val Pro Gln Lys Thr Tyr Ser Val Lys Val Leu Ala Phe Thr 
                485                 490                 495


Ser Ile Gly Asp Gly Pro Leu Ser Ser Asp Ile Gln Val Ile Thr Gln 
            500                 505                 510


Thr Gly Val Pro Gly Gln Pro Leu Asn Phe Lys Ala Glu Pro Glu Ser 
        515                 520                 525


Glu Thr Ser Ile Leu Leu Ser Trp Thr Pro Pro Arg Ser Asp Thr Ile 
    530                 535                 540


Ala Asn Tyr Glu Leu Val Tyr Lys Asp Gly Glu His Gly Glu Glu Gln 
545                 550                 555                 560


Arg Ile Thr Ile Glu Pro Gly Thr Ser Tyr Arg Leu Gln Gly Leu Lys 
                565                 570                 575


Pro Asn Ser Leu Tyr Tyr Phe Arg Leu Ala Ala Arg Ser Pro Gln Gly 
            580                 585                 590


Leu Gly Ala Ser Thr Ala Glu Ile Ser Ala Arg Thr Met Gln Ser Lys 
        595                 600                 605


Pro Ser Ala Pro Pro Gln Asp Ile Ser Cys Thr Ser Pro Ser Ser Thr 
    610                 615                 620


Ser Ile Leu Val Ser Trp Gln Pro Pro Pro Val Glu Lys Gln Asn Gly 
625                 630                 635                 640


Ile Ile Thr Glu Tyr Ser Ile Lys Tyr Thr Ala Val Asp Gly Glu Asp 
                645                 650                 655


Asp Lys Pro His Glu Ile Leu Gly Ile Pro Ser Asp Thr Thr Lys Tyr 
            660                 665                 670


Leu Leu Glu Gln Leu Glu Lys Trp Thr Glu Tyr Arg Ile Thr Val Thr 
        675                 680                 685


Ala His Thr Asp Val Gly Pro Gly Pro Glu Ser Leu Ser Val Leu Ile 
    690                 695                 700


Arg Thr Asn Glu Asp Val Pro Ser Gly Pro Pro Arg Lys Val Glu Val 
705                 710                 715                 720


Glu Ala Val Asn Ser Thr Ser Val Lys Val Ser Trp Arg Ser Pro Val 
                725                 730                 735


Pro Asn Lys Gln His Gly Gln Ile Arg Gly Tyr Gln Val His Tyr Val 
            740                 745                 750


Arg Met Glu Asn Gly Glu Pro Lys Gly Gln Pro Met Leu Lys Asp Val 
        755                 760                 765


Met Leu Ala Asp Ala Gln Trp Glu Phe Asp Asp Thr Thr Glu His Asp 
    770                 775                 780


Met Ile Ile Ser Gly Leu Gln Pro Glu Thr Ser Tyr Ser Leu Thr Val 
785                 790                 795                 800


Thr Ala Tyr Thr Thr Lys Gly Asp Gly Ala Arg Ser Lys Pro Lys Leu 
                805                 810                 815


Val Ser Thr Thr Gly Ala Val Pro Gly Lys Pro Arg Leu Val Ile Asn 
            820                 825                 830


His Thr Gln Met Asn Thr Ala Leu Ile Gln Trp His Pro Pro Val Asp 
        835                 840                 845


Thr Phe Gly Pro Leu Gln Gly Tyr Arg Leu Lys Phe Gly Arg Lys Asp 
    850                 855                 860


Met Glu Pro Leu Thr Thr Leu Glu Phe Ser Glu Lys Glu Asp His Phe 
865                 870                 875                 880


Thr Ala Thr Asp Ile His Lys Gly Ala Ser Tyr Val Phe Arg Leu Ser 
                885                 890                 895


Ala Arg Asn Lys Val Gly Phe Gly Glu Glu Met Val Lys Glu Ile Ser 
            900                 905                 910


Ile Pro Glu Glu Val Pro Thr Gly Phe Pro Gln Asn Leu His Ser Glu 
        915                 920                 925


Gly Thr Thr Ser Thr Ser Val Gln Leu Ser Trp Gln Pro Pro Val Leu 
    930                 935                 940


Ala Glu Arg Asn Gly Ile Ile Thr Lys Tyr Thr Leu Leu Tyr Arg Asp 
945                 950                 955                 960


Ile Asn Ile Pro Leu Leu Pro Met Glu Gln Leu Ile Val Pro Ala Asp 
                965                 970                 975


Thr Thr Met Thr Leu Thr Gly Leu Lys Pro Asp Thr Thr Tyr Asp Val 
            980                 985                 990


Lys Val Arg Ala His Thr Ser Lys Gly Pro Gly Pro Tyr Ser Pro Ser 
        995                 1000                1005


Val Gln Phe Arg Thr Leu Pro Val Asp Gln Val Phe Ala Lys Asn Phe 
    1010                1015                1020


His Val Lys Ala Val Met Lys Thr Ser Val Leu Leu Ser Trp Glu Ile 
1025                1030                1035                1040


Pro Glu Asn Tyr Asn Ser Ala Met Pro Phe Lys Ile Leu Tyr Asp Asp 
                1045                1050                1055


Gly Lys Met Val Glu Glu Val Asp Gly Arg Ala Thr Gln Lys Leu Ile 
            1060                1065                1070


Val Asn Leu Lys Pro Glu Lys Ser Tyr Ser Phe Val Leu Thr Asn Arg 
        1075                1080                1085


Gly Asn Ser Ala Gly Gly Leu Gln His Arg Val Thr Ala Lys Thr Ala 
    1090                1095                1100


Pro Asp Val Leu Arg Thr Lys Pro Ala Phe Ile Gly Lys Thr Asn Leu 
1105                1110                1115                1120


Asp Gly Met Ile Thr Val Gln Leu Pro Glu Val Pro Ala Asn Glu Asn 
                1125                1130                1135


Ile Lys Gly Tyr Tyr Ile Ile Ile Val Pro Leu Lys Lys Ser Arg Gly 
            1140                1145                1150


Lys Phe Ile Lys Pro Trp Glu Ser Pro Asp Glu Met Glu Leu Asp Glu 
        1155                1160                1165


Leu Leu Lys Glu Ile Ser Arg Lys Arg Arg Ser Ile Arg Tyr Gly Arg 
    1170                1175                1180


Glu Val Glu Leu Lys Pro Tyr Ile Ala Ala His Phe Asp Val Leu Pro 
1185                1190                1195                1200


Thr Glu Phe Thr Leu Gly Asp Asp Lys His Tyr Gly Gly Phe Thr Asn 
                1205                1210                1215


Lys Gln Leu Gln Ser Gly Gln Glu Tyr Val Phe Phe Val Leu Ala Val 
            1220                1225                1230


Met Glu His Ala Glu Ser Lys Met Tyr Ala Thr Ser Pro Tyr Ser Asp 
        1235                1240                1245


Pro Val Val Ser Met Asp Leu Asp Pro Gln Pro Ile Thr Asp Glu Glu 
    1250                1255                1260


Glu Gly Leu Ile Trp Val Val Gly Pro Val Leu Ala Val Val Phe Ile 
1265                1270                1275                1280


Ile Cys Ile Val Ile Ala Ile Leu Leu Tyr Lys Arg Lys Arg Ala Glu 
                1285                1290                1295


Ser Asp Ser Arg Lys Ser Ser Ile Pro Asn Asn Lys Glu Ile Pro Ser 
            1300                1305                1310


His His Pro Thr Asp Pro Val Glu Leu Arg Arg Leu Asn Phe Gln Thr 
        1315                1320                1325


Pro Gly Met Ala Ser His Pro Pro Ile Pro Ile Leu Glu Leu Ala Asp 
    1330                1335                1340


His Ile Glu Arg Leu Lys Ala Asn Asp Asn Leu Lys Phe Ser Gln Glu 
1345                1350                1355                1360


Tyr Glu Ser Ile Asp Pro Gly Gln Gln Phe Thr Trp Glu His Ser Asn 
                1365                1370                1375


Leu Glu Val Asn Lys Pro Lys Asn Arg Tyr Ala Asn Val Ile Ala Tyr 
            1380                1385                1390


Asp His Ser Arg Val Leu Leu Ser Ala Ile Glu Gly Ile Pro Gly Ser 
        1395                1400                1405


Asp Tyr Val Asn Ala Asn Tyr Ile Asp Gly Tyr Arg Lys Gln Asn Ala 
    1410                1415                1420


Tyr Ile Ala Thr Gln Gly Ser Leu Pro Glu Thr Phe Gly Asp Phe Trp 
1425                1430                1435                1440


Arg Met Ile Trp Glu Gln Arg Ser Ala Thr Val Val Met Met Thr Lys 
                1445                1450                1455


Leu Glu Glu Arg Ser Arg Val Lys Cys Asp Gln Tyr Trp Pro Ser Arg 
            1460                1465                1470


Gly Thr Glu Thr His Gly Leu Val Gln Val Thr Leu Leu Asp Thr Val 
        1475                1480                1485


Glu Leu Ala Thr Tyr Cys Val Arg Thr Phe Ala Leu Tyr Lys Asn Gly 
    1490                1495                1500


Ser Ser Glu Lys Arg Glu Val Arg Gln Phe Gln Phe Thr Ala Trp Pro 
1505                1510                1515                1520


Asp His Gly Val Pro Glu His Pro Thr Pro Phe Leu Ala Phe Leu Arg 
                1525                1530                1535


Arg Val Lys Thr Cys Asn Pro Pro Asp Ala Gly Pro Met Val Val His 
            1540                1545                1550


Cys Ser Ala Gly Val Gly Arg Thr Gly Cys Phe Ile Val Ile Asp Ala 
        1555                1560                1565


Met Leu Glu Arg Ile Lys His Glu Lys Thr Val Asp Ile Tyr Gly His 
    1570                1575                1580


Val Thr Leu Met Arg Ala Gln Arg Asn Tyr Met Val Gln Thr Glu Asp 
1585                1590                1595                1600


Gln Tyr Ile Phe Ile His Asp Ala Leu Leu Glu Ala Val Thr Cys Gly 
                1605                1610                1615


Asn Thr Glu Val Pro Ala Arg Asn Leu Tyr Ala Tyr Ile Gln Lys Leu 
            1620                1625                1630


Thr Gln Ile Glu Thr Gly Glu Asn Val Thr Gly Met Glu Leu Glu Phe 
        1635                1640                1645


Lys Arg Leu Ala Ser Ser Lys Ala His Thr Ser Arg Phe Ile Ser Ala 
    1650                1655                1660


Asn Leu Pro Cys Asn Lys Phe Lys Asn Arg Leu Val Asn Ile Met Pro 
1665                1670                1675                1680


Tyr Glu Ser Thr Arg Val Cys Leu Gln Pro Ile Arg Gly Val Glu Gly 
                1685                1690                1695


Ser Asp Tyr Ile Asn Ala Ser Phe Ile Asp Gly Tyr Arg Gln Gln Lys 
            1700                1705                1710


Ala Tyr Ile Ala Thr Gln Gly Pro Leu Ala Glu Thr Thr Glu Asp Phe 
        1715                1720                1725


Trp Arg Met Leu Trp Glu His Asn Ser Thr Ile Val Val Met Leu Thr 
    1730                1735                1740


Lys Leu Arg Glu Met Gly Arg Glu Lys Cys His Gln Tyr Trp Pro Ala 
1745                1750                1755                1760


Glu Arg Ser Ala Arg Tyr Gln Tyr Phe Val Val Asp Pro Met Ala Glu 
                1765                1770                1775


Tyr Asn Met Pro Gln Tyr Ile Leu Arg Glu Phe Lys Val Thr Asp Ala 
            1780                1785                1790


Arg Asp Gly Gln Ser Arg Thr Val Arg Gln Phe Gln Phe Thr Asp Trp 
        1795                1800                1805


Pro Glu Gln Gly Val Pro Lys Ser Gly Glu Gly Phe Ile Asp Phe Ile 
    1810                1815                1820


Gly Gln Val His Lys Thr Lys Glu Gln Phe Gly Gln Asp Gly Pro Ile 
1825                1830                1835                1840


Ser Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Val Phe Ile Thr 
                1845                1850                1855


Leu Ser Ile Val Leu Glu Arg Met Arg Tyr Glu Gly Val Val Asp Ile 
            1860                1865                1870


Phe Gln Thr Val Lys Met Leu Arg Thr Gln Arg Pro Ala Met Val Gln 
        1875                1880                1885


Thr Glu Asp Gln Tyr Gln Phe Ser Tyr Arg Ala Ala Leu Glu Tyr Leu 
    1890                1895                1900


Gly Ser Phe Asp His Tyr Ala Thr 
1905                1910


<210>  590
<211>  10039
<212>  DNA
<213>  Homo sapiens

<400>  590
gcagtttatt ctgggcctgt gtggaataga aagacaattc tttatttgac tggtaggaaa     60

gaaaagagaa gactcctcag ggtttccaag gaggactgga gcggctgctt tagtgaagaa    120

gtgaagaatc aaggaagtaa aggacctgtc tcaaagtcac acaactagga aatcttgagg    180

agtctgatac ttttcatcct ccagctataa aatcatcttg tagggggaag ctgtacattg    240

gtggaaaata aaaggcaagc agttcctggc ccgtgatatt ccagttagag gtgtctgact    300

gacagcatgt tggcaccgag ggaagcgatg ggcttcggct ccaggtttct gtcctgagac    360

cacagcagaa tgtgccttgg acaaaggctt ggactccttg atcttctggt aacttcaaaa    420

atctggtctc agggtggtga actttttctt cgaattccta acctgtgagc ttacgatgat    480

ggtgcctgtc cattaactga acaactgtgg ttttgaactt cttgaggcca gggactgtgt    540

ctgaaaacac cgacggtggc taactcaagg gagacgtctg gtgaacaccc gtgggatcta    600

aagaacaagc tctgaaagtg ttccagctga aatttcagat cggacagact cgctgcggct    660

ccggaggcag tgattccaag ctgctcgcgc acgctgctgc caagctgcag gatggtgcac    720

gtagccaggc tgctgctgct gctcctcact ttcttcctcc gcacggatgc tgagacacct    780

ccaaggttta cacgaacacc cgttgatcag acaggggtct ctggcggagt tgcctctttc    840

atctgccaag ctacgggaga cccaagacct aaaattgtct ggaacaaaaa aggaaagaaa    900

gtcagcaatc agagatttga ggtaatagag tttgacgatg ggtctggatc agttctcaga    960

atacaaccct tacggactcc gagggatgag gccatttatg aatgtgtggc ctcaaataat   1020

gtgggagaaa taagtgtatc caccagactc acagttttgc gggaagatca aattcccagg   1080

ggcttcccta ccattgacat gggcccacag ttgaaggtgg ttgagcgtac tcgcacggcc   1140

accatgcttt gtgcagccag tggtaatccg gatccagaaa tcacttggtt taaagatttc   1200

ttacctgtgg acacaagcaa caacaatggt cgtattaagc agttacgatc aggagccctt   1260

cagattgagc agagtgaaga gtctgaccaa ggaaaatatg agtgtgttgc caccaacagc   1320

gcgggcactc gctattccgc tcctgccaat ttatatgtca gagttcgccg tgtcccacca   1380

agattctcta tcccacccac taatcatgaa atcatgccag gcggaagcgt taatatcacc   1440

tgtgtggccg tggggtcacc aatgccttat gtaaagtgga tgttgggggc agaagatctg   1500

acacctgaag atgatatgcc aataggaaga aatgtgctag aactgaatga tgtaagacag   1560

tcagcaaatt acacctgtgt tgctatgtca acactgggtg tcattgaagc aatagcacag   1620

atcactgtca aagccttacc caaacctcca ggaactcctg tagtgaccga gagcacagct   1680

acaagcatca cactgacgtg ggactctggg aaccctgagc ctgtttctta ttacataatt   1740

cagcataaac ctaaaaactc tgaggaactt tacaaagaaa ttgatggggt ggcgaccaca   1800

cgctacagtg tcgctggact aagtccctac tcggattatg aattcagggt tgttgctgtc   1860

aataacattg ggcgggggcc tcccagcgaa cctgtgctaa cacaaacctc agagcaagca   1920

ccatccagtg ccccgaggga tgtccaggca cgaatgttga gttcgaccac cattttggta   1980

cagtggaagg aacctgaaga gccaaatgga cagatccaag gatatagagt ttattataca   2040

atggatccca ctcaacatgt caacaactgg atgaaacaca atgtagctga cagccaaatc   2100

actactattg gcaacttagt gccccagaaa acatattctg tcaaagtcct ggcttttacc   2160

tcaattggag atggtcccct ttcaagtgac atacaagtca tcactcagac aggagtacca   2220

gggcagccac taaacttcaa agcagaacct gagtctgaaa caagtatttt gctctcttgg   2280

acacctccac gttcagatac cattgccaac tatgaactgg tctacaaaga tggggagcat   2340

ggagaggagc aacgaattac cattgagcca gggacatcat ataggctgca aggactgaaa   2400

ccaaacagct tatactattt ccgtctggct gcacgctccc ctcaaggcct gggtgcttct   2460

actgcagaaa tatcagctag aaccatgcag tcaaagccgt cagctcctcc tcaagacatt   2520

agttgcacca gcccaagttc cactagtatt ttggtaagtt ggcaacctcc accagtggaa   2580

aaacagaatg gcattatcac tgaatactcc atcaagtaca ctgcagtgga tggggaagat   2640

gacaagcctc acgagatttt gggaattcct tcggacacta ccaaatacct tttggaacag   2700

ctggaaaaat ggactgaata ccggatcact gtgacagccc atacagatgt cggccctggc   2760

cctgagagct tgtccgtgtt gattcgaacc aatgaagatg ttcctagtgg tcctcctcgc   2820

aaagtcgagg tagaggctgt caactcaaca tctgttaaag tctcatggcg ctcacccgtg   2880

cccaataaac agcatggcca gataagagga tatcaggtgc attatgtgag gatggaaaat   2940

ggtgagccca agggccagcc catgctgaaa gatgtcatgc tggctgatgc acagtgggaa   3000

tttgatgata ctactgaaca tgacatgatc atttctgggc tccagcctga aacttcctac   3060

tccctcaccg tcacagccta cacaaccaaa ggagatggtg ctcgcagcaa gcccaaactg   3120

gtgtccacca ctggggcagt tccagggaaa cctcggcttg tgattaacca cactcagatg   3180

aatactgctc ttattcagtg gcaccctccg gtggacacat ttggacctct tcagggctac   3240

cgtctaaaat ttggccgcaa ggatatggag ccacttacta ctcttgagtt ctctgaaaaa   3300

gaagatcact ttacagctac agacatccac aagggagcat catacgtctt caggctctca   3360

gccagaaaca aagtgggctt tggggaggag atggtgaagg agatttccat tccagaagaa   3420

gtaccaactg gattccctca aaaccttcac tcagaaggca ccacttcaac ctccgtccag   3480

ttatcttggc aaccacctgt cctggcagag agaaatggca ttatcaccaa gtataccctt   3540

ctttataggg atatcaacat cccccttctc ccgatggagc agcttattgt tccagctgac   3600

accactatga cactcactgg cttaaaacca gataccacat acgatgtaaa agtacgtgct   3660

catacgagca aagggcccgg gccatatagt cccagtgtcc agttcaggac actgcctgtg   3720

gatcaagtgt ttgcaaaaaa ttttcatgtc aaagcagtaa tgaagacttc cgtgttgctg   3780

tcttgggaga ttccagagaa ttataactcc gccatgcctt tcaaaattct ttatgatgat   3840

gggaaaatgg tagaagaagt ggatggccga gccacacaga agttaattgt caacctgaag   3900

cctgagaaat catattcatt tgtgctgaca aatcgtggaa acagtgctgg tgggctgcag   3960

cacagggtca cggcaaagac tgcaccagat gtattacgta ccaagcctgc cttcattggg   4020

aagaccaact tggatggcat gattactgtg caactgcctg aagtacctgc aaatgagaat   4080

ataaaaggtt actacataat aattgtgcct ttgaagaaat ctcgcgggaa atttatcaag   4140

ccatgggaga gtccagatga aatggaatta gatgagctgc ttaaggagat atctaggaag   4200

cgcagaagca tccgttatgg gagagaagtt gaattaaagc catatattgc cgctcacttt   4260

gatgtccttc ccactgagtt caccctgggg gatgacaagc attatggtgg atttacaaac   4320

aagcaactcc aaagtggtca agaatatgtc ttctttgtgt tagcagtaat ggaacatgca   4380

gagtctaaga tgtatgcaac cagcccttac tccgaccccg tggtgtcaat ggatctggat   4440

ccgcagccaa tcacggatga agaagaaggc ttgatctggg ttgtaggtcc tgtccttgca   4500

gtggtcttta tcatctgcat tgtcattgct attcttcttt ataaaaggaa gagggcagag   4560

tccgactcta gaaaaagcag cataccgaac aataaggaga tcccttcaca ccacccaaca   4620

gaccctgtag aactgaggcg ccttaacttt caaacaccgg gtatggctag ccatcctcca   4680

atacccatct tggaacttgc agaccacatt gaaagattga aagcaaatga caacttgaag   4740

ttttcccagg aatatgagtc aattgaccct ggccagcagt tcacttggga acattcaaac   4800

ttggaagtaa acaaaccaaa gaatagatac gcgaatgtaa tcgcatatga tcattcccgg   4860

gttctcctat cagctataga agggatccca ggaagtgact atgtgaatgc caactacata   4920

gatgggtata ggaagcaaaa tgcctatatt gcaacacagg gatctctccc cgaaacattt   4980

ggggactttt ggagaatgat atgggaacaa cggagtgcca cagttgtcat gatgacaaaa   5040

ctagaagaaa gatcaagggt gaagtgtgac cagtattggc ctagcagagg cacagaaacc   5100

cacggactcg ttcaagtaac gctgcttgat actgtggagc tggccacata ttgtgttcga   5160

acatttgcac tttacaagaa tggttcaagt gagaagagag aagtgagaca attccagttc   5220

accgcctggc ctgatcatgg tgttccagaa caccctacac cttttctagc tttcttacgt   5280

agagtcaaaa cctgtaaccc tcccgatgct ggtccgatgg ttgtgcactg cagtgcggga   5340

gttggccgga ctggttgctt catcgtcata gatgccatgt tagaaagaat aaagcatgaa   5400

aaaactgtag atatttatgg ccatgtaact ttaatgagag cccagaggaa ctatatggtt   5460

caaacagaag accaatacat ctttatccat gatgcactgt tagaagcagt gacttgtgga   5520

aataccgaag tgccagctag aaacttgtat gcctacattc agaagctgac acaaatagaa   5580

acgggagaga atgtcacagg aatggagctc gaatttaagc gtctagccag ctcaaaagct   5640

cacacctcaa ggtttatcag tgccaatctt ccatgtaata aattcaaaaa tcgccttgtt   5700

aatattatgc catatgaatc cacaagggta tgcctgcagc ctatccgtgg agtagaagga   5760

tctgattaca tcaatgccag ttttattgat ggatacagac aacagaaagc ctacatcgct   5820

acccaggggc ccttggcaga gaccactgaa gacttctggc ggatgctctg ggaacacaat   5880

tccaccatag ttgtgatgct caccaagctg cgtgaaatgg gcagagagaa atgtcaccaa   5940

tactggccag cagaacggtc tgcaagatac cagtactttg ttgtagatcc catggctgag   6000

tacaacatgc cacagtatat cctaagggaa ttcaaggtca cagatgccag ggacggccag   6060

tcccgaacag taaggcagtt ccagttcact gactggccag agcaaggagt gccaaagtcc   6120

ggagaaggat ttattgactt catcggccaa gtccataaaa caaaagaaca gtttggccaa   6180

gatggaccca tttcagtcca ttgcagcgcg ggcgttggaa gaactggagt cttcataacg   6240

ctaagcattg ttttggaaag aatgagatat gaaggagttg tagatatctt ccagactgtc   6300

aaaatgttaa gaacacaacg accagctatg gtacagacag aggatcaata tcagttttcc   6360

tatcgtgccg cactagagta cctgggcagc tttgaccact atgcaacgta gaaacccctg   6420

acccattctg gatttttact acaggccctt caatatccat ggagtctctt ctgagccata   6480

cagggcactt gagaagtcct tcttaacttc tagctaacaa ctacttagtg ggactattac   6540

acacaaaaca aattaaaaac aaattattcc aggtggacca agaattcaca gtttaataat   6600

ctaacctgaa aaataatgaa gagaatcctg actgatgagg catctgaagg attttattta   6660

cagatacctc aaggattcaa aatcaaggga agaagaaatc acagcaaaga accaccatct   6720

tattcaggat tgcttgaaag gtgcaaggag aaattgccag aatgctgcag ttcagcacaa   6780

gatatgtgct ggtgtggctt ctcacaatga aacggactct gctttgacat cgccccttcc   6840

caccatactg ctcataataa cattttaggg ggaaagggga gggaatgttt aaaaagaaag   6900

tccttgattt agttttttag tattgtaaag atactgctga cctgtgcttc atttctaact   6960

gtgtaaactt ttttttaaca aaatgtatca ttcgataaag tgaattttaa aaaagttaca   7020

taactcttca tttttttatt tccaaatcgt aggttttttt aagctgtaga actgttatct   7080

gtaatatctt gctgtagaaa tatcaaatca tttgaaaatt tgcacatttt tgtgcaaaac   7140

tcaatctaca gtatcagtct cgtcagatat attaatttta cacttcagtt ttgattggtg   7200

agaaagtacc cattctcttc aaataatcaa agataattat tattttgttt tgtttttgga   7260

atcaacaggg aggcgcaaag tataaagttg ctgctaacat atatacatat atatccatat   7320

tttataaggg tgtctatgta tatatagaca gtgtgtccac acaaaaaata gatacagtta   7380

tcagtcagtc agttcttcca tgatttagtt tttttaaacg tagaaaagct attgtaaaca   7440

tctctttcca tttattctta attttttgac atattggtat ttctttaaag ggaaatgagg   7500

aatgcacatc agtgattgat tgtcaaacct caccccctga tttcctacct aatctacccc   7560

cacctaacca atcaatcaca tccacaaatt gttttgtttg tttgttagtc aggcttccaa   7620

caaagttcaa tatttctaac actctagtgc aataaaaatt attattaaat agctaagagg   7680

tgtgcatgtg ggaaaggtca gtgcatatcc ctttaggagg ggagaatgtt gtaatatatc   7740

agctatcgag ttgtttaaaa aaagtgtatt caatcgtata ttgtctatag tatgtgctat   7800

gaaatttgca tttatgatat gtaacagggg caaagccaaa ttcatgttac tctgttcagt   7860

cagaaacatt ttgtggcata cagcattcct gggaagtgct gtactttgtt tcgttttggt   7920

tttagttttg catttagagt gccttataat tgatgcctat tttaatagca tttcttttta   7980

gcttttggtt cgtatttcca ttcactgttc gtatctgtta ctttctatta aagcattatc   8040

tgtttaccac atgtacaaaa actctttgaa taatatgcat tcctagtttt cagccaagtc   8100

ggggatgtta gtgattgtac cagcccaaag cacttggata atcagggccc ttcttccttt   8160

tataatcaat catcaacatc agaaaaagct acttgtttta tttatattcc cttccaaatc   8220

cgctctggaa catgcagtaa ctgcaccaaa cttattttag taacaaatat cattggcaac   8280

tttggaatat atttgatatt ccattaggat ttttctaaaa ggggaaataa actatatata   8340

tatatgtatc ttacccccaa ttcttccaac agaatttcta taggaagcca tggatgatgg   8400

cataagtttg ccacatatta catgatttta aataatcctc aaaataccca aggaactctt   8460

aaagagtttt ggtatgagta tactactttg gtttaatttt agcttcatgg atgttctgca   8520

tggaaggatt tttgttttcc acattttccc attgctagca gagtgaaatc caagagacca   8580

aacatttgca agcattgtat ttgagcactt ttgtaaaaaa caaagaaaaa gaaaaaaaag   8640

aaaatatata taatactaaa aaaaagtatc tagaaggcta cctcagaatg agactctcta   8700

acctacatca gaaccagaga agaatgtgca ctatgtgggt ctgttatcat tattttcttt   8760

tagtttgtat ctttttggag atttatccaa gtgccagatt actcagtgct ataattttct   8820

tttagttaaa caaagggggt cagacagaca ttgcatcatc cagacatgcc ttgttggaca   8880

tgtagaatcc gatggagcac tgcacaccag aatgattggc caatgagcag cttctctccc   8940

tgaaacaata actgcccatt tggcaaaggg aaagatgaca ataatcagaa gaagaaaatg   9000

aatgggatgc ataccataga cgaacgaggc ggagactatt gcgggaatct tactgttcag   9060

gagctgttcc tagaactaac tcccttactg tcattgatgt gcattccact ctgtgctttt   9120

ctgtacaacc attcaagttt taatttccca ggtgaaccat ctttatctgc cattaccaca   9180

agctttcaag tttccagtta ttttcatcat cataaccagt acggtgctat tatttaccta   9240

tgtacgtgta gttatgtata attttgtaat tagttacaat ggtaaaaaaa atcaaaatat   9300

ataaaaagtg atttgtacag aactttattt tagctctttt ttaaaaatga tttgcatggt   9360

tagaaaacgg cgaggacagc caggggaggg aagggcctct agggaacttt gcactttcta   9420

tacctttgta ctatgcactg ccctattgat tctacaccca ataatgatat tacttgaacc   9480

catctgtaag aaactgcttc ggaaattcat ttgtgtgtat gtaaataaca caacatagaa   9540

acaggaaggg aaaaaagtct gcagtaatgc acgtattttt tttctttcct gtttattttc   9600

ggttttgctt taagtccttt tatttttaat tccctttttg tttttctttt tgggttttgg   9660

ttccttttgg gtttatgggt gccctgatac tccagcagag atcagaaggc tacagatcca   9720

ttctatccat ccgttatgtg gctttgccat cccagcttgg agtgtcttta caaagataat   9780

aacagttgtg ttctttgctc tcgttttgga tgcatagact gaaaaattaa aacaaataac   9840

ttgtaaaatg gcttgttaaa aaatacaatt acctctaatt agtagtacgc gtaaatgttt   9900

tacagaatga aaggcgtgct ttttattttc ttacttcgtt acattggtgg cgaaagaagt   9960

ctgtatgaaa atcagttctt tgctgacaca agttccattt gttacaaatg aattctaata  10020

aaaatgtcag tgttatgca                                               10039


<210>  591
<211>  1899
<212>  PRT
<213>  Homo sapiens

<400>  591

Met Val His Val Ala Arg Leu Leu Leu Leu Leu Leu Thr Phe Phe Leu 
1               5                   10                  15


Arg Thr Asp Ala Glu Thr Pro Pro Arg Phe Thr Arg Thr Pro Val Asp 
            20                  25                  30


Gln Thr Gly Val Ser Gly Gly Val Ala Ser Phe Ile Cys Gln Ala Thr 
        35                  40                  45


Gly Asp Pro Arg Pro Lys Ile Val Trp Asn Lys Lys Gly Lys Lys Val 
    50                  55                  60


Ser Asn Gln Arg Phe Glu Val Ile Glu Phe Asp Asp Gly Ser Gly Ser 
65                  70                  75                  80


Val Leu Arg Ile Gln Pro Leu Arg Thr Pro Arg Asp Glu Ala Ile Tyr 
                85                  90                  95


Glu Cys Val Ala Ser Asn Asn Val Gly Glu Ile Ser Val Ser Thr Arg 
            100                 105                 110


Leu Thr Val Leu Arg Glu Asp Gln Ile Pro Arg Gly Phe Pro Thr Ile 
        115                 120                 125


Asp Met Gly Pro Gln Leu Lys Val Val Glu Arg Thr Arg Thr Ala Thr 
    130                 135                 140


Met Leu Cys Ala Ala Ser Gly Asn Pro Asp Pro Glu Ile Thr Trp Phe 
145                 150                 155                 160


Lys Asp Phe Leu Pro Val Asp Thr Ser Asn Asn Asn Gly Arg Ile Lys 
                165                 170                 175


Gln Leu Arg Ser Gly Ala Leu Gln Ile Glu Gln Ser Glu Glu Ser Asp 
            180                 185                 190


Gln Gly Lys Tyr Glu Cys Val Ala Thr Asn Ser Ala Gly Thr Arg Tyr 
        195                 200                 205


Ser Ala Pro Ala Asn Leu Tyr Val Arg Val Arg Arg Val Pro Pro Arg 
    210                 215                 220


Phe Ser Ile Pro Pro Thr Asn His Glu Ile Met Pro Gly Gly Ser Val 
225                 230                 235                 240


Asn Ile Thr Cys Val Ala Val Gly Ser Pro Met Pro Tyr Val Lys Trp 
                245                 250                 255


Met Leu Gly Ala Glu Asp Leu Thr Pro Glu Asp Asp Met Pro Ile Gly 
            260                 265                 270


Arg Asn Val Leu Glu Leu Asn Asp Val Arg Gln Ser Ala Asn Tyr Thr 
        275                 280                 285


Cys Val Ala Met Ser Thr Leu Gly Val Ile Glu Ala Ile Ala Gln Ile 
    290                 295                 300


Thr Val Lys Ala Leu Pro Lys Pro Pro Gly Thr Pro Val Val Thr Glu 
305                 310                 315                 320


Ser Thr Ala Thr Ser Ile Thr Leu Thr Trp Asp Ser Gly Asn Pro Glu 
                325                 330                 335


Pro Val Ser Tyr Tyr Ile Ile Gln His Lys Pro Lys Asn Ser Glu Glu 
            340                 345                 350


Leu Tyr Lys Glu Ile Asp Gly Val Ala Thr Thr Arg Tyr Ser Val Ala 
        355                 360                 365


Gly Leu Ser Pro Tyr Ser Asp Tyr Glu Phe Arg Val Val Ala Val Asn 
    370                 375                 380


Asn Ile Gly Arg Gly Pro Pro Ser Glu Pro Val Leu Thr Gln Thr Ser 
385                 390                 395                 400


Glu Gln Ala Pro Ser Ser Ala Pro Arg Asp Val Gln Ala Arg Met Leu 
                405                 410                 415


Ser Ser Thr Thr Ile Leu Val Gln Trp Lys Glu Pro Glu Glu Pro Asn 
            420                 425                 430


Gly Gln Ile Gln Gly Tyr Arg Val Tyr Tyr Thr Met Asp Pro Thr Gln 
        435                 440                 445


His Val Asn Asn Trp Met Lys His Asn Val Ala Asp Ser Gln Ile Thr 
    450                 455                 460


Thr Ile Gly Asn Leu Val Pro Gln Lys Thr Tyr Ser Val Lys Val Leu 
465                 470                 475                 480


Ala Phe Thr Ser Ile Gly Asp Gly Pro Leu Ser Ser Asp Ile Gln Val 
                485                 490                 495


Ile Thr Gln Thr Gly Val Pro Gly Gln Pro Leu Asn Phe Lys Ala Glu 
            500                 505                 510


Pro Glu Ser Glu Thr Ser Ile Leu Leu Ser Trp Thr Pro Pro Arg Ser 
        515                 520                 525


Asp Thr Ile Ala Asn Tyr Glu Leu Val Tyr Lys Asp Gly Glu His Gly 
    530                 535                 540


Glu Glu Gln Arg Ile Thr Ile Glu Pro Gly Thr Ser Tyr Arg Leu Gln 
545                 550                 555                 560


Gly Leu Lys Pro Asn Ser Leu Tyr Tyr Phe Arg Leu Ala Ala Arg Ser 
                565                 570                 575


Pro Gln Gly Leu Gly Ala Ser Thr Ala Glu Ile Ser Ala Arg Thr Met 
            580                 585                 590


Gln Ser Lys Pro Ser Ala Pro Pro Gln Asp Ile Ser Cys Thr Ser Pro 
        595                 600                 605


Ser Ser Thr Ser Ile Leu Val Ser Trp Gln Pro Pro Pro Val Glu Lys 
    610                 615                 620


Gln Asn Gly Ile Ile Thr Glu Tyr Ser Ile Lys Tyr Thr Ala Val Asp 
625                 630                 635                 640


Gly Glu Asp Asp Lys Pro His Glu Ile Leu Gly Ile Pro Ser Asp Thr 
                645                 650                 655


Thr Lys Tyr Leu Leu Glu Gln Leu Glu Lys Trp Thr Glu Tyr Arg Ile 
            660                 665                 670


Thr Val Thr Ala His Thr Asp Val Gly Pro Gly Pro Glu Ser Leu Ser 
        675                 680                 685


Val Leu Ile Arg Thr Asn Glu Asp Val Pro Ser Gly Pro Pro Arg Lys 
    690                 695                 700


Val Glu Val Glu Ala Val Asn Ser Thr Ser Val Lys Val Ser Trp Arg 
705                 710                 715                 720


Ser Pro Val Pro Asn Lys Gln His Gly Gln Ile Arg Gly Tyr Gln Val 
                725                 730                 735


His Tyr Val Arg Met Glu Asn Gly Glu Pro Lys Gly Gln Pro Met Leu 
            740                 745                 750


Lys Asp Val Met Leu Ala Asp Ala Gln Trp Glu Phe Asp Asp Thr Thr 
        755                 760                 765


Glu His Asp Met Ile Ile Ser Gly Leu Gln Pro Glu Thr Ser Tyr Ser 
    770                 775                 780


Leu Thr Val Thr Ala Tyr Thr Thr Lys Gly Asp Gly Ala Arg Ser Lys 
785                 790                 795                 800


Pro Lys Leu Val Ser Thr Thr Gly Ala Val Pro Gly Lys Pro Arg Leu 
                805                 810                 815


Val Ile Asn His Thr Gln Met Asn Thr Ala Leu Ile Gln Trp His Pro 
            820                 825                 830


Pro Val Asp Thr Phe Gly Pro Leu Gln Gly Tyr Arg Leu Lys Phe Gly 
        835                 840                 845


Arg Lys Asp Met Glu Pro Leu Thr Thr Leu Glu Phe Ser Glu Lys Glu 
    850                 855                 860


Asp His Phe Thr Ala Thr Asp Ile His Lys Gly Ala Ser Tyr Val Phe 
865                 870                 875                 880


Arg Leu Ser Ala Arg Asn Lys Val Gly Phe Gly Glu Glu Met Val Lys 
                885                 890                 895


Glu Ile Ser Ile Pro Glu Glu Val Pro Thr Gly Phe Pro Gln Asn Leu 
            900                 905                 910


His Ser Glu Gly Thr Thr Ser Thr Ser Val Gln Leu Ser Trp Gln Pro 
        915                 920                 925


Pro Val Leu Ala Glu Arg Asn Gly Ile Ile Thr Lys Tyr Thr Leu Leu 
    930                 935                 940


Tyr Arg Asp Ile Asn Ile Pro Leu Leu Pro Met Glu Gln Leu Ile Val 
945                 950                 955                 960


Pro Ala Asp Thr Thr Met Thr Leu Thr Gly Leu Lys Pro Asp Thr Thr 
                965                 970                 975


Tyr Asp Val Lys Val Arg Ala His Thr Ser Lys Gly Pro Gly Pro Tyr 
            980                 985                 990


Ser Pro Ser Val Gln Phe Arg Thr Leu Pro Val Asp Gln Val Phe Ala 
        995                 1000                1005


Lys Asn Phe His Val Lys Ala Val Met Lys Thr Ser Val Leu Leu Ser 
    1010                1015                1020


Trp Glu Ile Pro Glu Asn Tyr Asn Ser Ala Met Pro Phe Lys Ile Leu 
1025                1030                1035                1040


Tyr Asp Asp Gly Lys Met Val Glu Glu Val Asp Gly Arg Ala Thr Gln 
                1045                1050                1055


Lys Leu Ile Val Asn Leu Lys Pro Glu Lys Ser Tyr Ser Phe Val Leu 
            1060                1065                1070


Thr Asn Arg Gly Asn Ser Ala Gly Gly Leu Gln His Arg Val Thr Ala 
        1075                1080                1085


Lys Thr Ala Pro Asp Val Leu Arg Thr Lys Pro Ala Phe Ile Gly Lys 
    1090                1095                1100


Thr Asn Leu Asp Gly Met Ile Thr Val Gln Leu Pro Glu Val Pro Ala 
1105                1110                1115                1120


Asn Glu Asn Ile Lys Gly Tyr Tyr Ile Ile Ile Val Pro Leu Lys Lys 
                1125                1130                1135


Ser Arg Gly Lys Phe Ile Lys Pro Trp Glu Ser Pro Asp Glu Met Glu 
            1140                1145                1150


Leu Asp Glu Leu Leu Lys Glu Ile Ser Arg Lys Arg Arg Ser Ile Arg 
        1155                1160                1165


Tyr Gly Arg Glu Val Glu Leu Lys Pro Tyr Ile Ala Ala His Phe Asp 
    1170                1175                1180


Val Leu Pro Thr Glu Phe Thr Leu Gly Asp Asp Lys His Tyr Gly Gly 
1185                1190                1195                1200


Phe Thr Asn Lys Gln Leu Gln Ser Gly Gln Glu Tyr Val Phe Phe Val 
                1205                1210                1215


Leu Ala Val Met Glu His Ala Glu Ser Lys Met Tyr Ala Thr Ser Pro 
            1220                1225                1230


Tyr Ser Asp Pro Val Val Ser Met Asp Leu Asp Pro Gln Pro Ile Thr 
        1235                1240                1245


Asp Glu Glu Glu Gly Leu Ile Trp Val Val Gly Pro Val Leu Ala Val 
    1250                1255                1260


Val Phe Ile Ile Cys Ile Val Ile Ala Ile Leu Leu Tyr Lys Arg Lys 
1265                1270                1275                1280


Arg Ala Glu Ser Asp Ser Arg Lys Ser Ser Ile Pro Asn Asn Lys Glu 
                1285                1290                1295


Ile Pro Ser His His Pro Thr Asp Pro Val Glu Leu Arg Arg Leu Asn 
            1300                1305                1310


Phe Gln Thr Pro Gly Met Ala Ser His Pro Pro Ile Pro Ile Leu Glu 
        1315                1320                1325


Leu Ala Asp His Ile Glu Arg Leu Lys Ala Asn Asp Asn Leu Lys Phe 
    1330                1335                1340


Ser Gln Glu Tyr Glu Ser Ile Asp Pro Gly Gln Gln Phe Thr Trp Glu 
1345                1350                1355                1360


His Ser Asn Leu Glu Val Asn Lys Pro Lys Asn Arg Tyr Ala Asn Val 
                1365                1370                1375


Ile Ala Tyr Asp His Ser Arg Val Leu Leu Ser Ala Ile Glu Gly Ile 
            1380                1385                1390


Pro Gly Ser Asp Tyr Val Asn Ala Asn Tyr Ile Asp Gly Tyr Arg Lys 
        1395                1400                1405


Gln Asn Ala Tyr Ile Ala Thr Gln Gly Ser Leu Pro Glu Thr Phe Gly 
    1410                1415                1420


Asp Phe Trp Arg Met Ile Trp Glu Gln Arg Ser Ala Thr Val Val Met 
1425                1430                1435                1440


Met Thr Lys Leu Glu Glu Arg Ser Arg Val Lys Cys Asp Gln Tyr Trp 
                1445                1450                1455


Pro Ser Arg Gly Thr Glu Thr His Gly Leu Val Gln Val Thr Leu Leu 
            1460                1465                1470


Asp Thr Val Glu Leu Ala Thr Tyr Cys Val Arg Thr Phe Ala Leu Tyr 
        1475                1480                1485


Lys Asn Gly Ser Ser Glu Lys Arg Glu Val Arg Gln Phe Gln Phe Thr 
    1490                1495                1500


Ala Trp Pro Asp His Gly Val Pro Glu His Pro Thr Pro Phe Leu Ala 
1505                1510                1515                1520


Phe Leu Arg Arg Val Lys Thr Cys Asn Pro Pro Asp Ala Gly Pro Met 
                1525                1530                1535


Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Cys Phe Ile Val 
            1540                1545                1550


Ile Asp Ala Met Leu Glu Arg Ile Lys His Glu Lys Thr Val Asp Ile 
        1555                1560                1565


Tyr Gly His Val Thr Leu Met Arg Ala Gln Arg Asn Tyr Met Val Gln 
    1570                1575                1580


Thr Glu Asp Gln Tyr Ile Phe Ile His Asp Ala Leu Leu Glu Ala Val 
1585                1590                1595                1600


Thr Cys Gly Asn Thr Glu Val Pro Ala Arg Asn Leu Tyr Ala Tyr Ile 
                1605                1610                1615


Gln Lys Leu Thr Gln Ile Glu Thr Gly Glu Asn Val Thr Gly Met Glu 
            1620                1625                1630


Leu Glu Phe Lys Arg Leu Ala Ser Ser Lys Ala His Thr Ser Arg Phe 
        1635                1640                1645


Ile Ser Ala Asn Leu Pro Cys Asn Lys Phe Lys Asn Arg Leu Val Asn 
    1650                1655                1660


Ile Met Pro Tyr Glu Ser Thr Arg Val Cys Leu Gln Pro Ile Arg Gly 
1665                1670                1675                1680


Val Glu Gly Ser Asp Tyr Ile Asn Ala Ser Phe Ile Asp Gly Tyr Arg 
                1685                1690                1695


Gln Gln Lys Ala Tyr Ile Ala Thr Gln Gly Pro Leu Ala Glu Thr Thr 
            1700                1705                1710


Glu Asp Phe Trp Arg Met Leu Trp Glu His Asn Ser Thr Ile Val Val 
        1715                1720                1725


Met Leu Thr Lys Leu Arg Glu Met Gly Arg Glu Lys Cys His Gln Tyr 
    1730                1735                1740


Trp Pro Ala Glu Arg Ser Ala Arg Tyr Gln Tyr Phe Val Val Asp Pro 
1745                1750                1755                1760


Met Ala Glu Tyr Asn Met Pro Gln Tyr Ile Leu Arg Glu Phe Lys Val 
                1765                1770                1775


Thr Asp Ala Arg Asp Gly Gln Ser Arg Thr Val Arg Gln Phe Gln Phe 
            1780                1785                1790


Thr Asp Trp Pro Glu Gln Gly Val Pro Lys Ser Gly Glu Gly Phe Ile 
        1795                1800                1805


Asp Phe Ile Gly Gln Val His Lys Thr Lys Glu Gln Phe Gly Gln Asp 
    1810                1815                1820


Gly Pro Ile Ser Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Val 
1825                1830                1835                1840


Phe Ile Thr Leu Ser Ile Val Leu Glu Arg Met Arg Tyr Glu Gly Val 
                1845                1850                1855


Val Asp Ile Phe Gln Thr Val Lys Met Leu Arg Thr Gln Arg Pro Ala 
            1860                1865                1870


Met Val Gln Thr Glu Asp Gln Tyr Gln Phe Ser Tyr Arg Ala Ala Leu 
        1875                1880                1885


Glu Tyr Leu Gly Ser Phe Asp His Tyr Ala Thr 
    1890                1895


<210>  592
<211>  10051
<212>  DNA
<213>  Homo sapiens

<400>  592
gcagtttatt ctgggcctgt gtggaataga aagacaattc tttatttgac tggtaggaaa     60

gaaaagagaa gactcctcag ggtttccaag gaggactgga gcggctgctt tagtgaagaa    120

gtgaagaatc aaggaagtaa aggacctgtc tcaaagtcac acaactagga aatcttgagg    180

agtctgatac ttttcatcct ccagctataa aatcatcttg tagggggaag ctgtacattg    240

gtggaaaata aaaggcaagc agttcctggc ccgtgatatt ccagttagag gtgtctgact    300

gacagcatgt tggcaccgag ggaagcgatg ggcttcggct ccaggtttct gtcctgagac    360

cacagcagaa tgtgccttgg acaaaggctt ggactccttg atcttctggt aacttcaaaa    420

atctggtctc agggtggtga actttttctt cgaattccta acctgtgagc ttacgatgat    480

ggtgcctgtc cattaactga acaactgtgg ttttgaactt cttgaggcca gggactgtgt    540

ctgaaaacac cgacggtggc taactcaagg gagacgtctg gtgaacaccc gtgggatcta    600

aagaacaagc tctgaaagtg ttccagctga aatttcagat cggacagact cgctgcggct    660

ccggaggcag tgattccaag ctgctcgcgc acgctgctgc caagctgcag gatggtgcac    720

gtagccaggc tgctgctgct gctcctcact ttcttcctcc gcacggatgc tgagacacct    780

ccaaggttta cacgaacacc cgttgatcag acaggggtct ctggcggagt tgcctctttc    840

atctgccaag ctacgggaga cccaagacct aaaattgtct ggaacaaaaa aggaaagaaa    900

gtcagcaatc agagatttga ggtaatagag tttgacgatg ggtctggatc agttctcaga    960

atacaaccct tacggactcc gagggatgag gccatttatg aatgtgtggc ctcaaataat   1020

gtgggagaaa taagtgtatc caccagactc acagttttgc gggaagatca aattcccagg   1080

ggcttcccta ccattgacat gggcccacag ttgaaggtgg ttgagcgtac tcgcacggcc   1140

accatgcttt gtgcagccag tggtaatccg gatccagaaa tcacttggtt taaagatttc   1200

ttacctgtgg acacaagcaa caacaatggt cgtattaagc agttacgatc agaatctatt   1260

ggtggtacac caataagagg agcccttcag attgagcaga gtgaagagtc tgaccaagga   1320

aaatatgagt gtgttgccac caacagcgcg ggcactcgct attccgctcc tgccaattta   1380

tatgtcagag agctgcgaga agttcgccgt gtcccaccaa gattctctat cccacccact   1440

aatcatgaaa tcatgccagg cggaagcgtt aatatcacct gtgtggccgt ggggtcacca   1500

atgccttatg taaagtggat gttgggggca gaagatctga cacctgaaga tgatatgcca   1560

ataggaagaa atgtgctaga actgaatgat gtaagacagt cagcaaatta cacctgtgtt   1620

gctatgtcaa cactgggtgt cattgaagca atagcacaga tcactgtcaa agccttaccc   1680

aaacctccag gaactcctgt agtgaccgag agcacagcta caagcatcac actgacgtgg   1740

gactctggga accctgagcc tgtttcttat tacataattc agcataaacc taaaaactct   1800

gaggaacttt acaaagaaat tgatggggtg gcgaccacac gctacagtgt cgctggacta   1860

agtccctact cggattatga attcagggtt gttgctgtca ataacattgg gcgggggcct   1920

cccagcgaac ctgtgctaac acaaacctca gagcaagcac catccagtgc cccgagggat   1980

gtccaggcac gaatgttgag ttcgaccacc attttggtac agtggaagga acctgaagag   2040

ccaaatggac agatccaagg atatagagtt tattatacaa tggatcccac tcaacatgtc   2100

aacaactgga tgaaacacaa tgtagctgac agccaaatca ctactattgg caacttagtg   2160

ccccagaaaa catattctgt caaagtcctg gcttttacct caattggaga tggtcccctt   2220

tcaagtgaca tacaagtcat cactcagaca ggagtaccag ggcagccact aaacttcaaa   2280

gcagaacctg agtctgaaac aagtattttg ctctcttgga cacctccacg ttcagatacc   2340

attgccaact atgaactggt ctacaaagat ggggagcatg gagaggagca acgaattacc   2400

attgagccag ggacatcata taggctgcaa ggactgaaac caaacagctt atactatttc   2460

cgtctggctg cacgctcccc tcaaggcctg ggtgcttcta ctgcagaaat atcagctaga   2520

accatgcagt caaagccgtc agctcctcct caagacatta gttgcaccag cccaagttcc   2580

actagtattt tggtaagttg gcaacctcca ccagtggaaa aacagaatgg cattatcact   2640

gaatactcca tcaagtacac tgcagtggat ggggaagatg acaagcctca cgagattttg   2700

ggaattcctt cggacactac caaatacctt ttggaacagc tggaaaaatg gactgaatac   2760

cggatcactg tgacagccca tacagatgtc ggccctggcc ctgagagctt gtccgtgttg   2820

attcgaacca atgaagatgt tcctagtggt cctcctcgca aagtcgaggt agaggctgtc   2880

aactcaacat ctgttaaagt ctcatggcgc tcacccgtgc ccaataaaca gcatggccag   2940

ataagaggat atcaggtgca ttatgtgagg atggaaaatg gtgagcccaa gggccagccc   3000

atgctgaaag atgtcatgct ggctgatgca caggacatga tcatttctgg gctccagcct   3060

gaaacttcct actccctcac cgtcacagcc tacacaacca aaggagatgg tgctcgcagc   3120

aagcccaaac tggtgtccac cactggggca gttccaggga aacctcggct tgtgattaac   3180

cacactcaga tgaatactgc tcttattcag tggcaccctc cggtggacac atttggacct   3240

cttcagggct accgtctaaa atttggccgc aaggatatgg agccacttac tactcttgag   3300

ttctctgaaa aagaagatca ctttacagct acagacatcc acaagggagc atcatacgtc   3360

ttcaggctct cagccagaaa caaagtgggc tttggggagg agatggtgaa ggagatttcc   3420

attccagaag aagtaccaac tggattccct caaaaccttc actcagaagg caccacttca   3480

acctccgtcc agttatcttg gcaaccacct gtcctggcag agagaaatgg cattatcacc   3540

aagtataccc ttctttatag ggatatcaac atcccccttc tcccgatgga gcagcttatt   3600

gttccagctg acaccactat gacactcact ggcttaaaac cagataccac atacgatgta   3660

aaagtacgtg ctcatacgag caaagggccc gggccatata gtcccagtgt ccagttcagg   3720

acactgcctg tggatcaagt gtttgcaaaa aattttcatg tcaaagcagt aatgaagact   3780

tccgtgttgc tgtcttggga gattccagag aattataact ccgccatgcc tttcaaaatt   3840

ctttatgatg atgggaaaat ggtagaagaa gtggatggcc gagccacaca gaagttaatt   3900

gtcaacctga agcctgagaa atcatattca tttgtgctga caaatcgtgg aaacagtgct   3960

ggtgggctgc agcacagggt cacggcaaag actgcaccag atgtattacg taccaagcct   4020

gccttcattg ggaagaccaa cttggatggc atgattactg tgcaactgcc tgaagtacct   4080

gcaaatgaga atataaaagg ttactacata ataattgtgc ctttgaagaa atctcgcggg   4140

aaatttatca agccatggga gagtccagat gaaatggaat tagatgagct gcttaaggag   4200

atatctagga agcgcagaag catccgttat gggagagaag ttgaattaaa gccatatatt   4260

gccgctcact ttgatgtcct tcccactgag ttcaccctgg gggatgacaa gcattatggt   4320

ggatttacaa acaagcaact ccaaagtggt caagaatatg tcttctttgt gttagcagta   4380

atggaacatg cagagtctaa gatgtatgca accagccctt actccgaccc cgtggtgtca   4440

atggatctgg atccgcagcc aatcacggat gaagaagaag gcttgatctg ggttgtaggt   4500

cctgtccttg cagtggtctt tatcatctgc attgtcattg ctattcttct ttataaaagg   4560

aagagggcag agtccgactc tagaaaaagc agcataccga acaataagga gatcccttca   4620

caccacccaa cagaccctgt agaactgagg cgccttaact ttcaaacacc gggtatggct   4680

agccatcctc caatacccat cttggaactt gcagaccaca ttgaaagatt gaaagcaaat   4740

gacaacttga agttttccca ggaatatgag tcaattgacc ctggccagca gttcacttgg   4800

gaacattcaa acttggaagt aaacaaacca aagaatagat acgcgaatgt aatcgcatat   4860

gatcattccc gggttctcct atcagctata gaagggatcc caggaagtga ctatgtgaat   4920

gccaactaca tagatgggta taggaagcaa aatgcctata ttgcaacaca gggatctctc   4980

cccgaaacat ttggggactt ttggagaatg atatgggaac aacggagtgc cacagttgtc   5040

atgatgacaa aactagaaga aagatcaagg gtgaagtgtg accagtattg gcctagcaga   5100

ggcacagaaa cccacggact cgttcaagta acgctgcttg atactgtgga gctggccaca   5160

tattgtgttc gaacatttgc actttacaag aatggttcaa gtgagaagag agaagtgaga   5220

caattccagt tcaccgcctg gcctgatcat ggtgttccag aacaccctac accttttcta   5280

gctttcttac gtagagtcaa aacctgtaac cctcccgatg ctggtccgat ggttgtgcac   5340

tgcagtgcgg gagttggccg gactggttgc ttcatcgtca tagatgccat gttagaaaga   5400

ataaagcatg aaaaaactgt agatatttat ggccatgtaa ctttaatgag agcccagagg   5460

aactatatgg ttcaaacaga agaccaatac atctttatcc atgatgcact gttagaagca   5520

gtgacttgtg gaaataccga agtgccagct agaaacttgt atgcctacat tcagaagctg   5580

acacaaatag aaacgggaga gaatgtcaca ggaatggagc tcgaatttaa gcgtctagcc   5640

agctcaaaag ctcacacctc aaggtttatc agtgccaatc ttccatgtaa taaattcaaa   5700

aatcgccttg ttaatattat gccatatgaa tccacaaggg tatgcctgca gcctatccgt   5760

ggagtagaag gatctgatta catcaatgcc agttttattg atggatacag acaacagaaa   5820

gcctacatcg ctacccaggg gcccttggca gagaccactg aagacttctg gcggatgctc   5880

tgggaacaca attccaccat agttgtgatg ctcaccaagc tgcgtgaaat gggcagagag   5940

aaatgtcacc aatactggcc agcagaacgg tctgcaagat accagtactt tgttgtagat   6000

cccatggctg agtacaacat gccacagtat atcctaaggg aattcaaggt cacagatgcc   6060

agggacggcc agtcccgaac agtaaggcag ttccagttca ctgactggcc agagcaagga   6120

gtgccaaagt ccggagaagg atttattgac ttcatcggcc aagtccataa aacaaaagaa   6180

cagtttggcc aagatggacc catttcagtc cattgcagcg cgggcgttgg aagaactgga   6240

gtcttcataa cgctaagcat tgttttggaa agaatgagat atgaaggagt tgtagatatc   6300

ttccagactg tcaaaatgtt aagaacacaa cgaccagcta tggtacagac agaggatcaa   6360

tatcagtttt cctatcgtgc cgcactagag tacctgggca gctttgacca ctatgcaacg   6420

tagaaacccc tgacccattc tggattttta ctacaggccc ttcaatatcc atggagtctc   6480

ttctgagcca tacagggcac ttgagaagtc cttcttaact tctagctaac aactacttag   6540

tgggactatt acacacaaaa caaattaaaa acaaattatt ccaggtggac caagaattca   6600

cagtttaata atctaacctg aaaaataatg aagagaatcc tgactgatga ggcatctgaa   6660

ggattttatt tacagatacc tcaaggattc aaaatcaagg gaagaagaaa tcacagcaaa   6720

gaaccaccat cttattcagg attgcttgaa aggtgcaagg agaaattgcc agaatgctgc   6780

agttcagcac aagatatgtg ctggtgtggc ttctcacaat gaaacggact ctgctttgac   6840

atcgcccctt cccaccatac tgctcataat aacattttag ggggaaaggg gagggaatgt   6900

ttaaaaagaa agtccttgat ttagtttttt agtattgtaa agatactgct gacctgtgct   6960

tcatttctaa ctgtgtaaac ttttttttaa caaaatgtat cattcgataa agtgaatttt   7020

aaaaaagtta cataactctt cattttttta tttccaaatc gtaggttttt ttaagctgta   7080

gaactgttat ctgtaatatc ttgctgtaga aatatcaaat catttgaaaa tttgcacatt   7140

tttgtgcaaa actcaatcta cagtatcagt ctcgtcagat atattaattt tacacttcag   7200

ttttgattgg tgagaaagta cccattctct tcaaataatc aaagataatt attattttgt   7260

tttgtttttg gaatcaacag ggaggcgcaa agtataaagt tgctgctaac atatatacat   7320

atatatccat attttataag ggtgtctatg tatatataga cagtgtgtcc acacaaaaaa   7380

tagatacagt tatcagtcag tcagttcttc catgatttag tttttttaaa cgtagaaaag   7440

ctattgtaaa catctctttc catttattct taattttttg acatattggt atttctttaa   7500

agggaaatga ggaatgcaca tcagtgattg attgtcaaac ctcaccccct gatttcctac   7560

ctaatctacc cccacctaac caatcaatca catccacaaa ttgttttgtt tgtttgttag   7620

tcaggcttcc aacaaagttc aatatttcta acactctagt gcaataaaaa ttattattaa   7680

atagctaaga ggtgtgcatg tgggaaaggt cagtgcatat ccctttagga ggggagaatg   7740

ttgtaatata tcagctatcg agttgtttaa aaaaagtgta ttcaatcgta tattgtctat   7800

agtatgtgct atgaaatttg catttatgat atgtaacagg ggcaaagcca aattcatgtt   7860

actctgttca gtcagaaaca ttttgtggca tacagcattc ctgggaagtg ctgtactttg   7920

tttcgttttg gttttagttt tgcatttaga gtgccttata attgatgcct attttaatag   7980

catttctttt tagcttttgg ttcgtatttc cattcactgt tcgtatctgt tactttctat   8040

taaagcatta tctgtttacc acatgtacaa aaactctttg aataatatgc attcctagtt   8100

ttcagccaag tcggggatgt tagtgattgt accagcccaa agcacttgga taatcagggc   8160

ccttcttcct tttataatca atcatcaaca tcagaaaaag ctacttgttt tatttatatt   8220

cccttccaaa tccgctctgg aacatgcagt aactgcacca aacttatttt agtaacaaat   8280

atcattggca actttggaat atatttgata ttccattagg atttttctaa aaggggaaat   8340

aaactatata tatatatgta tcttaccccc aattcttcca acagaatttc tataggaagc   8400

catggatgat ggcataagtt tgccacatat tacatgattt taaataatcc tcaaaatacc   8460

caaggaactc ttaaagagtt ttggtatgag tatactactt tggtttaatt ttagcttcat   8520

ggatgttctg catggaagga tttttgtttt ccacattttc ccattgctag cagagtgaaa   8580

tccaagagac caaacatttg caagcattgt atttgagcac ttttgtaaaa aacaaagaaa   8640

aagaaaaaaa agaaaatata tataatacta aaaaaaagta tctagaaggc tacctcagaa   8700

tgagactctc taacctacat cagaaccaga gaagaatgtg cactatgtgg gtctgttatc   8760

attattttct tttagtttgt atctttttgg agatttatcc aagtgccaga ttactcagtg   8820

ctataatttt cttttagtta aacaaagggg gtcagacaga cattgcatca tccagacatg   8880

ccttgttgga catgtagaat ccgatggagc actgcacacc agaatgattg gccaatgagc   8940

agcttctctc cctgaaacaa taactgccca tttggcaaag ggaaagatga caataatcag   9000

aagaagaaaa tgaatgggat gcataccata gacgaacgag gcggagacta ttgcgggaat   9060

cttactgttc aggagctgtt cctagaacta actcccttac tgtcattgat gtgcattcca   9120

ctctgtgctt ttctgtacaa ccattcaagt tttaatttcc caggtgaacc atctttatct   9180

gccattacca caagctttca agtttccagt tattttcatc atcataacca gtacggtgct   9240

attatttacc tatgtacgtg tagttatgta taattttgta attagttaca atggtaaaaa   9300

aaatcaaaat atataaaaag tgatttgtac agaactttat tttagctctt ttttaaaaat   9360

gatttgcatg gttagaaaac ggcgaggaca gccaggggag ggaagggcct ctagggaact   9420

ttgcactttc tatacctttg tactatgcac tgccctattg attctacacc caataatgat   9480

attacttgaa cccatctgta agaaactgct tcggaaattc atttgtgtgt atgtaaataa   9540

cacaacatag aaacaggaag ggaaaaaagt ctgcagtaat gcacgtattt tttttctttc   9600

ctgtttattt tcggttttgc tttaagtcct tttattttta attccctttt tgtttttctt   9660

tttgggtttt ggttcctttt gggtttatgg gtgccctgat actccagcag agatcagaag   9720

gctacagatc cattctatcc atccgttatg tggctttgcc atcccagctt ggagtgtctt   9780

tacaaagata ataacagttg tgttctttgc tctcgttttg gatgcataga ctgaaaaatt   9840

aaaacaaata acttgtaaaa tggcttgtta aaaaatacaa ttacctctaa ttagtagtac   9900

gcgtaaatgt tttacagaat gaaaggcgtg ctttttattt tcttacttcg ttacattggt   9960

ggcgaaagaa gtctgtatga aaatcagttc tttgctgaca caagttccat ttgttacaaa  10020

tgaattctaa taaaaatgtc agtgttatgc a                                 10051


<210>  593
<211>  1903
<212>  PRT
<213>  Homo sapiens

<400>  593

Met Val His Val Ala Arg Leu Leu Leu Leu Leu Leu Thr Phe Phe Leu 
1               5                   10                  15


Arg Thr Asp Ala Glu Thr Pro Pro Arg Phe Thr Arg Thr Pro Val Asp 
            20                  25                  30


Gln Thr Gly Val Ser Gly Gly Val Ala Ser Phe Ile Cys Gln Ala Thr 
        35                  40                  45


Gly Asp Pro Arg Pro Lys Ile Val Trp Asn Lys Lys Gly Lys Lys Val 
    50                  55                  60


Ser Asn Gln Arg Phe Glu Val Ile Glu Phe Asp Asp Gly Ser Gly Ser 
65                  70                  75                  80


Val Leu Arg Ile Gln Pro Leu Arg Thr Pro Arg Asp Glu Ala Ile Tyr 
                85                  90                  95


Glu Cys Val Ala Ser Asn Asn Val Gly Glu Ile Ser Val Ser Thr Arg 
            100                 105                 110


Leu Thr Val Leu Arg Glu Asp Gln Ile Pro Arg Gly Phe Pro Thr Ile 
        115                 120                 125


Asp Met Gly Pro Gln Leu Lys Val Val Glu Arg Thr Arg Thr Ala Thr 
    130                 135                 140


Met Leu Cys Ala Ala Ser Gly Asn Pro Asp Pro Glu Ile Thr Trp Phe 
145                 150                 155                 160


Lys Asp Phe Leu Pro Val Asp Thr Ser Asn Asn Asn Gly Arg Ile Lys 
                165                 170                 175


Gln Leu Arg Ser Glu Ser Ile Gly Gly Thr Pro Ile Arg Gly Ala Leu 
            180                 185                 190


Gln Ile Glu Gln Ser Glu Glu Ser Asp Gln Gly Lys Tyr Glu Cys Val 
        195                 200                 205


Ala Thr Asn Ser Ala Gly Thr Arg Tyr Ser Ala Pro Ala Asn Leu Tyr 
    210                 215                 220


Val Arg Glu Leu Arg Glu Val Arg Arg Val Pro Pro Arg Phe Ser Ile 
225                 230                 235                 240


Pro Pro Thr Asn His Glu Ile Met Pro Gly Gly Ser Val Asn Ile Thr 
                245                 250                 255


Cys Val Ala Val Gly Ser Pro Met Pro Tyr Val Lys Trp Met Leu Gly 
            260                 265                 270


Ala Glu Asp Leu Thr Pro Glu Asp Asp Met Pro Ile Gly Arg Asn Val 
        275                 280                 285


Leu Glu Leu Asn Asp Val Arg Gln Ser Ala Asn Tyr Thr Cys Val Ala 
    290                 295                 300


Met Ser Thr Leu Gly Val Ile Glu Ala Ile Ala Gln Ile Thr Val Lys 
305                 310                 315                 320


Ala Leu Pro Lys Pro Pro Gly Thr Pro Val Val Thr Glu Ser Thr Ala 
                325                 330                 335


Thr Ser Ile Thr Leu Thr Trp Asp Ser Gly Asn Pro Glu Pro Val Ser 
            340                 345                 350


Tyr Tyr Ile Ile Gln His Lys Pro Lys Asn Ser Glu Glu Leu Tyr Lys 
        355                 360                 365


Glu Ile Asp Gly Val Ala Thr Thr Arg Tyr Ser Val Ala Gly Leu Ser 
    370                 375                 380


Pro Tyr Ser Asp Tyr Glu Phe Arg Val Val Ala Val Asn Asn Ile Gly 
385                 390                 395                 400


Arg Gly Pro Pro Ser Glu Pro Val Leu Thr Gln Thr Ser Glu Gln Ala 
                405                 410                 415


Pro Ser Ser Ala Pro Arg Asp Val Gln Ala Arg Met Leu Ser Ser Thr 
            420                 425                 430


Thr Ile Leu Val Gln Trp Lys Glu Pro Glu Glu Pro Asn Gly Gln Ile 
        435                 440                 445


Gln Gly Tyr Arg Val Tyr Tyr Thr Met Asp Pro Thr Gln His Val Asn 
    450                 455                 460


Asn Trp Met Lys His Asn Val Ala Asp Ser Gln Ile Thr Thr Ile Gly 
465                 470                 475                 480


Asn Leu Val Pro Gln Lys Thr Tyr Ser Val Lys Val Leu Ala Phe Thr 
                485                 490                 495


Ser Ile Gly Asp Gly Pro Leu Ser Ser Asp Ile Gln Val Ile Thr Gln 
            500                 505                 510


Thr Gly Val Pro Gly Gln Pro Leu Asn Phe Lys Ala Glu Pro Glu Ser 
        515                 520                 525


Glu Thr Ser Ile Leu Leu Ser Trp Thr Pro Pro Arg Ser Asp Thr Ile 
    530                 535                 540


Ala Asn Tyr Glu Leu Val Tyr Lys Asp Gly Glu His Gly Glu Glu Gln 
545                 550                 555                 560


Arg Ile Thr Ile Glu Pro Gly Thr Ser Tyr Arg Leu Gln Gly Leu Lys 
                565                 570                 575


Pro Asn Ser Leu Tyr Tyr Phe Arg Leu Ala Ala Arg Ser Pro Gln Gly 
            580                 585                 590


Leu Gly Ala Ser Thr Ala Glu Ile Ser Ala Arg Thr Met Gln Ser Lys 
        595                 600                 605


Pro Ser Ala Pro Pro Gln Asp Ile Ser Cys Thr Ser Pro Ser Ser Thr 
    610                 615                 620


Ser Ile Leu Val Ser Trp Gln Pro Pro Pro Val Glu Lys Gln Asn Gly 
625                 630                 635                 640


Ile Ile Thr Glu Tyr Ser Ile Lys Tyr Thr Ala Val Asp Gly Glu Asp 
                645                 650                 655


Asp Lys Pro His Glu Ile Leu Gly Ile Pro Ser Asp Thr Thr Lys Tyr 
            660                 665                 670


Leu Leu Glu Gln Leu Glu Lys Trp Thr Glu Tyr Arg Ile Thr Val Thr 
        675                 680                 685


Ala His Thr Asp Val Gly Pro Gly Pro Glu Ser Leu Ser Val Leu Ile 
    690                 695                 700


Arg Thr Asn Glu Asp Val Pro Ser Gly Pro Pro Arg Lys Val Glu Val 
705                 710                 715                 720


Glu Ala Val Asn Ser Thr Ser Val Lys Val Ser Trp Arg Ser Pro Val 
                725                 730                 735


Pro Asn Lys Gln His Gly Gln Ile Arg Gly Tyr Gln Val His Tyr Val 
            740                 745                 750


Arg Met Glu Asn Gly Glu Pro Lys Gly Gln Pro Met Leu Lys Asp Val 
        755                 760                 765


Met Leu Ala Asp Ala Gln Asp Met Ile Ile Ser Gly Leu Gln Pro Glu 
    770                 775                 780


Thr Ser Tyr Ser Leu Thr Val Thr Ala Tyr Thr Thr Lys Gly Asp Gly 
785                 790                 795                 800


Ala Arg Ser Lys Pro Lys Leu Val Ser Thr Thr Gly Ala Val Pro Gly 
                805                 810                 815


Lys Pro Arg Leu Val Ile Asn His Thr Gln Met Asn Thr Ala Leu Ile 
            820                 825                 830


Gln Trp His Pro Pro Val Asp Thr Phe Gly Pro Leu Gln Gly Tyr Arg 
        835                 840                 845


Leu Lys Phe Gly Arg Lys Asp Met Glu Pro Leu Thr Thr Leu Glu Phe 
    850                 855                 860


Ser Glu Lys Glu Asp His Phe Thr Ala Thr Asp Ile His Lys Gly Ala 
865                 870                 875                 880


Ser Tyr Val Phe Arg Leu Ser Ala Arg Asn Lys Val Gly Phe Gly Glu 
                885                 890                 895


Glu Met Val Lys Glu Ile Ser Ile Pro Glu Glu Val Pro Thr Gly Phe 
            900                 905                 910


Pro Gln Asn Leu His Ser Glu Gly Thr Thr Ser Thr Ser Val Gln Leu 
        915                 920                 925


Ser Trp Gln Pro Pro Val Leu Ala Glu Arg Asn Gly Ile Ile Thr Lys 
    930                 935                 940


Tyr Thr Leu Leu Tyr Arg Asp Ile Asn Ile Pro Leu Leu Pro Met Glu 
945                 950                 955                 960


Gln Leu Ile Val Pro Ala Asp Thr Thr Met Thr Leu Thr Gly Leu Lys 
                965                 970                 975


Pro Asp Thr Thr Tyr Asp Val Lys Val Arg Ala His Thr Ser Lys Gly 
            980                 985                 990


Pro Gly Pro Tyr Ser Pro Ser Val Gln Phe Arg Thr Leu Pro Val Asp 
        995                 1000                1005


Gln Val Phe Ala Lys Asn Phe His Val Lys Ala Val Met Lys Thr Ser 
    1010                1015                1020


Val Leu Leu Ser Trp Glu Ile Pro Glu Asn Tyr Asn Ser Ala Met Pro 
1025                1030                1035                1040


Phe Lys Ile Leu Tyr Asp Asp Gly Lys Met Val Glu Glu Val Asp Gly 
                1045                1050                1055


Arg Ala Thr Gln Lys Leu Ile Val Asn Leu Lys Pro Glu Lys Ser Tyr 
            1060                1065                1070


Ser Phe Val Leu Thr Asn Arg Gly Asn Ser Ala Gly Gly Leu Gln His 
        1075                1080                1085


Arg Val Thr Ala Lys Thr Ala Pro Asp Val Leu Arg Thr Lys Pro Ala 
    1090                1095                1100


Phe Ile Gly Lys Thr Asn Leu Asp Gly Met Ile Thr Val Gln Leu Pro 
1105                1110                1115                1120


Glu Val Pro Ala Asn Glu Asn Ile Lys Gly Tyr Tyr Ile Ile Ile Val 
                1125                1130                1135


Pro Leu Lys Lys Ser Arg Gly Lys Phe Ile Lys Pro Trp Glu Ser Pro 
            1140                1145                1150


Asp Glu Met Glu Leu Asp Glu Leu Leu Lys Glu Ile Ser Arg Lys Arg 
        1155                1160                1165


Arg Ser Ile Arg Tyr Gly Arg Glu Val Glu Leu Lys Pro Tyr Ile Ala 
    1170                1175                1180


Ala His Phe Asp Val Leu Pro Thr Glu Phe Thr Leu Gly Asp Asp Lys 
1185                1190                1195                1200


His Tyr Gly Gly Phe Thr Asn Lys Gln Leu Gln Ser Gly Gln Glu Tyr 
                1205                1210                1215


Val Phe Phe Val Leu Ala Val Met Glu His Ala Glu Ser Lys Met Tyr 
            1220                1225                1230


Ala Thr Ser Pro Tyr Ser Asp Pro Val Val Ser Met Asp Leu Asp Pro 
        1235                1240                1245


Gln Pro Ile Thr Asp Glu Glu Glu Gly Leu Ile Trp Val Val Gly Pro 
    1250                1255                1260


Val Leu Ala Val Val Phe Ile Ile Cys Ile Val Ile Ala Ile Leu Leu 
1265                1270                1275                1280


Tyr Lys Arg Lys Arg Ala Glu Ser Asp Ser Arg Lys Ser Ser Ile Pro 
                1285                1290                1295


Asn Asn Lys Glu Ile Pro Ser His His Pro Thr Asp Pro Val Glu Leu 
            1300                1305                1310


Arg Arg Leu Asn Phe Gln Thr Pro Gly Met Ala Ser His Pro Pro Ile 
        1315                1320                1325


Pro Ile Leu Glu Leu Ala Asp His Ile Glu Arg Leu Lys Ala Asn Asp 
    1330                1335                1340


Asn Leu Lys Phe Ser Gln Glu Tyr Glu Ser Ile Asp Pro Gly Gln Gln 
1345                1350                1355                1360


Phe Thr Trp Glu His Ser Asn Leu Glu Val Asn Lys Pro Lys Asn Arg 
                1365                1370                1375


Tyr Ala Asn Val Ile Ala Tyr Asp His Ser Arg Val Leu Leu Ser Ala 
            1380                1385                1390


Ile Glu Gly Ile Pro Gly Ser Asp Tyr Val Asn Ala Asn Tyr Ile Asp 
        1395                1400                1405


Gly Tyr Arg Lys Gln Asn Ala Tyr Ile Ala Thr Gln Gly Ser Leu Pro 
    1410                1415                1420


Glu Thr Phe Gly Asp Phe Trp Arg Met Ile Trp Glu Gln Arg Ser Ala 
1425                1430                1435                1440


Thr Val Val Met Met Thr Lys Leu Glu Glu Arg Ser Arg Val Lys Cys 
                1445                1450                1455


Asp Gln Tyr Trp Pro Ser Arg Gly Thr Glu Thr His Gly Leu Val Gln 
            1460                1465                1470


Val Thr Leu Leu Asp Thr Val Glu Leu Ala Thr Tyr Cys Val Arg Thr 
        1475                1480                1485


Phe Ala Leu Tyr Lys Asn Gly Ser Ser Glu Lys Arg Glu Val Arg Gln 
    1490                1495                1500


Phe Gln Phe Thr Ala Trp Pro Asp His Gly Val Pro Glu His Pro Thr 
1505                1510                1515                1520


Pro Phe Leu Ala Phe Leu Arg Arg Val Lys Thr Cys Asn Pro Pro Asp 
                1525                1530                1535


Ala Gly Pro Met Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly 
            1540                1545                1550


Cys Phe Ile Val Ile Asp Ala Met Leu Glu Arg Ile Lys His Glu Lys 
        1555                1560                1565


Thr Val Asp Ile Tyr Gly His Val Thr Leu Met Arg Ala Gln Arg Asn 
    1570                1575                1580


Tyr Met Val Gln Thr Glu Asp Gln Tyr Ile Phe Ile His Asp Ala Leu 
1585                1590                1595                1600


Leu Glu Ala Val Thr Cys Gly Asn Thr Glu Val Pro Ala Arg Asn Leu 
                1605                1610                1615


Tyr Ala Tyr Ile Gln Lys Leu Thr Gln Ile Glu Thr Gly Glu Asn Val 
            1620                1625                1630


Thr Gly Met Glu Leu Glu Phe Lys Arg Leu Ala Ser Ser Lys Ala His 
        1635                1640                1645


Thr Ser Arg Phe Ile Ser Ala Asn Leu Pro Cys Asn Lys Phe Lys Asn 
    1650                1655                1660


Arg Leu Val Asn Ile Met Pro Tyr Glu Ser Thr Arg Val Cys Leu Gln 
1665                1670                1675                1680


Pro Ile Arg Gly Val Glu Gly Ser Asp Tyr Ile Asn Ala Ser Phe Ile 
                1685                1690                1695


Asp Gly Tyr Arg Gln Gln Lys Ala Tyr Ile Ala Thr Gln Gly Pro Leu 
            1700                1705                1710


Ala Glu Thr Thr Glu Asp Phe Trp Arg Met Leu Trp Glu His Asn Ser 
        1715                1720                1725


Thr Ile Val Val Met Leu Thr Lys Leu Arg Glu Met Gly Arg Glu Lys 
    1730                1735                1740


Cys His Gln Tyr Trp Pro Ala Glu Arg Ser Ala Arg Tyr Gln Tyr Phe 
1745                1750                1755                1760


Val Val Asp Pro Met Ala Glu Tyr Asn Met Pro Gln Tyr Ile Leu Arg 
                1765                1770                1775


Glu Phe Lys Val Thr Asp Ala Arg Asp Gly Gln Ser Arg Thr Val Arg 
            1780                1785                1790


Gln Phe Gln Phe Thr Asp Trp Pro Glu Gln Gly Val Pro Lys Ser Gly 
        1795                1800                1805


Glu Gly Phe Ile Asp Phe Ile Gly Gln Val His Lys Thr Lys Glu Gln 
    1810                1815                1820


Phe Gly Gln Asp Gly Pro Ile Ser Val His Cys Ser Ala Gly Val Gly 
1825                1830                1835                1840


Arg Thr Gly Val Phe Ile Thr Leu Ser Ile Val Leu Glu Arg Met Arg 
                1845                1850                1855


Tyr Glu Gly Val Val Asp Ile Phe Gln Thr Val Lys Met Leu Arg Thr 
            1860                1865                1870


Gln Arg Pro Ala Met Val Gln Thr Glu Asp Gln Tyr Gln Phe Ser Tyr 
        1875                1880                1885


Arg Ala Ala Leu Glu Tyr Leu Gly Ser Phe Asp His Tyr Ala Thr 
    1890                1895                1900


<210>  594
<211>  8845
<212>  DNA
<213>  Homo sapiens

<400>  594
gcagtttatt ctgggcctgt gtggaataga aagacaattc tttatttgac tggtaggaaa     60

gaaaagagaa gactcctcag ggtttccaag gaggactgga gcggctgctt tagtgaagaa    120

gtgaagaatc aaggaagtaa aggacctgtc tcaaagtcac acaactagga aatcttgagg    180

agtctgatac ttttcatcct ccagctataa aatcatcttg tagggggaag ctgtacattg    240

gtggaaaata aaaggcaagc agttcctggc ccgtgatatt ccagttagag gtgtctgact    300

gacagcatgt tggcaccgag ggaagcgatg ggcttcggct ccaggtttct gtcctgagac    360

cacagcagaa tgtgccttgg acaaaggctt ggactccttg atcttctggt aacttcaaaa    420

atctggtctc agggtggtga actttttctt cgaattccta acctgtgagc ttacgatgat    480

ggtgcctgtc cattaactga acaactgtgg ttttgaactt cttgaggcca gggactgtgt    540

ctgaaaacac cgacggtggc taactcaagg gagacgtctg gtgaacaccc gtgggatcta    600

aagaacaagc tctgaaagtg ttccagctga aatttcagat cggacagact cgctgcggct    660

ccggaggcag tgattccaag ctgctcgcgc acgctgctgc caagctgcag gatggtgcac    720

gtagccaggc tgctgctgct gctcctcact ttcttcctcc gcacggatgc tgagacacct    780

ccaaggttta cacgaacacc cgttgatcag acaggggtct ctggcggagt tgcctctttc    840

atctgccaag ctacgggaga cccaagacct aaaattgtct ggaacaaaaa aggaaagaaa    900

gtcagcaatc agagatttga ggtaatagag tttgacgatg ggtctggatc agttctcaga    960

atacaaccct tacggactcc gagggatgag gccatttatg aatgtgtggc ctcaaataat   1020

gtgggagaaa taagtgtatc caccagactc acagttttgc gggaagatca aattcccagg   1080

ggcttcccta ccattgacat gggcccacag ttgaaggtgg ttgagcgtac tcgcacggcc   1140

accatgcttt gtgcagccag tggtaatccg gatccagaaa tcacttggtt taaagatttc   1200

ttacctgtgg acacaagcaa caacaatggt cgtattaagc agttacgatc agaatctatt   1260

ggtggtacac caataagagg agcccttcag attgagcaga gtgaagagtc tgaccaagga   1320

aaatatgagt gtgttgccac caacagcgcg ggcactcgct attccgctcc tgccaattta   1380

tatgtcagag agctgcgaga agttcgccgt gtcccaccaa gattctctat cccacccact   1440

aatcatgaaa tcatgccagg cggaagcgtt aatatcacct gtgtggccgt ggggtcacca   1500

atgccttatg taaagtggat gttgggggca gaagatctga cacctgaaga tgatatgcca   1560

ataggaagaa atgtgctaga actgaatgat gtaagacagt cagcaaatta cacctgtgtt   1620

gctatgtcaa cactgggtgt cattgaagca atagcacaga tcactgtcaa agccttaccc   1680

aaacctccag gaactcctgt agtgaccgag agcacagcta caagcatcac actgacgtgg   1740

gactctggga accctgagcc tgtttcttat tacataattc agcataaacc taaaaactct   1800

gaggaacttt acaaagaaat tgatggggtg gcgaccacac gctacagtgt cgctggacta   1860

agtccctact cggattatga attcagggtt gttgctgtca ataacattgg gcgggggcct   1920

cccagcgaac ctgtgctaac acaaacctca gagcaagcac catccagtgc cccgagggat   1980

gtccaggcac gaatgttgag ttcgaccacc attttggtac agtggaagga acctgaagag   2040

ccaaatggac agatccaagg atatagagtt tattatacaa tggatcccac tcaacatgtc   2100

aacaactgga tgaaacacaa tgtagctgac agccaaatca ctactattgg caacttagtg   2160

ccccagaaaa catattctgt caaagtcctg gcttttacct caattggaga tggtcccctt   2220

tcaagtgaca tacaagtcat cactcagaca ggagtaccag ggcagccact aaacttcaaa   2280

gcagaacctg agtctgaaac aagtattttg ctctcttgga cacctccacg ttcagatacc   2340

attgccaact atgaactggt ctacaaagat ggggagcatg gagaggagca acgaattacc   2400

attgagccag ggacatcata taggctgcaa ggactgaaac caaacagctt atactatttc   2460

cgtctggctg cacgctcccc tcaaggcctg ggtgcttcta ctgcagaaat atcagctaga   2520

accatgcagt caatgtttgc aaaaaatttt catgtcaaag cagtaatgaa gacttccgtg   2580

ttgctgtctt gggagattcc agagaattat aactccgcca tgcctttcaa aattctttat   2640

gatgatggga aaatggtaga agaagtggat ggccgagcca cacagaagtt aattgtcaac   2700

ctgaagcctg agaaatcata ttcatttgtg ctgacaaatc gtggaaacag tgctggtggg   2760

ctgcagcaca gggtcacggc aaagactgca ccagatgtat tacgtaccaa gcctgccttc   2820

attgggaaga ccaacttgga tggcatgatt actgtgcaac tgcctgaagt acctgcaaat   2880

gagaatataa aaggttacta cataataatt gtgcctttga agaaatctcg cgggaaattt   2940

atcaagccat gggagagtcc agatgaaatg gaattagatg agctgcttaa ggagatatct   3000

aggaagcgca gaagcatccg ttatgggaga gaagttgaat taaagccata tattgccgct   3060

cactttgatg tccttcccac tgagttcacc ctgggggatg acaagcatta tggtggattt   3120

acaaacaagc aactccaaag tggtcaagaa tatgtcttct ttgtgttagc agtaatggaa   3180

catgcagagt ctaagatgta tgcaaccagc ccttactccg accccgtggt gtcaatggat   3240

ctggatccgc agccaatcac ggatgaagaa gaaggcttga tctgggttgt aggtcctgtc   3300

cttgcagtgg tctttatcat ctgcattgtc attgctattc ttctttataa aaggaagagg   3360

gcagagtccg actctagaaa aagcagcata ccgaacaata aggagatccc ttcacaccac   3420

ccaacagacc ctgtagaact gaggcgcctt aactttcaaa caccgggtat ggctagccat   3480

cctccaatac ccatcttgga acttgcagac cacattgaaa gattgaaagc aaatgacaac   3540

ttgaagtttt cccaggaata tgagtcaatt gaccctggcc agcagttcac ttgggaacat   3600

tcaaacttgg aagtaaacaa accaaagaat agatacgcga atgtaatcgc atatgatcat   3660

tcccgggttc tcctatcagc tatagaaggg atcccaggaa gtgactatgt gaatgccaac   3720

tacatagatg ggtataggaa gcaaaatgcc tatattgcaa cacagggatc tctccccgaa   3780

acatttgggg acttttggag aatgatatgg gaacaacgga gtgccacagt tgtcatgatg   3840

acaaaactag aagaaagatc aagggtgaag tgtgaccagt attggcctag cagaggcaca   3900

gaaacccacg gactcgttca agtaacgctg cttgatactg tggagctggc cacatattgt   3960

gttcgaacat ttgcacttta caagaatggt tcaagtgaga agagagaagt gagacaattc   4020

cagttcaccg cctggcctga tcatggtgtt ccagaacacc ctacaccttt tctagctttc   4080

ttacgtagag tcaaaacctg taaccctccc gatgctggtc cgatggttgt gcactgcagt   4140

gcgggagttg gccggactgg ttgcttcatc gtcatagatg ccatgttaga aagaataaag   4200

catgaaaaaa ctgtagatat ttatggccat gtaactttaa tgagagccca gaggaactat   4260

atggttcaaa cagaagacca atacatcttt atccatgatg cactgttaga agcagtgact   4320

tgtggaaata ccgaagtgcc agctagaaac ttgtatgcct acattcagaa gctgacacaa   4380

atagaaacgg gagagaatgt cacaggaatg gagctcgaat ttaagcgtct agccagctca   4440

aaagctcaca cctcaaggtt tatcagtgcc aatcttccat gtaataaatt caaaaatcgc   4500

cttgttaata ttatgccata tgaatccaca agggtatgcc tgcagcctat ccgtggagta   4560

gaaggatctg attacatcaa tgccagtttt attgatggat acagacaaca gaaagcctac   4620

atcgctaccc aggggccctt ggcagagacc actgaagact tctggcggat gctctgggaa   4680

cacaattcca ccatagttgt gatgctcacc aagctgcgtg aaatgggcag agagaaatgt   4740

caccaatact ggccagcaga acggtctgca agataccagt actttgttgt agatcccatg   4800

gctgagtaca acatgccaca gtatatccta agggaattca aggtcacaga tgccagggac   4860

ggccagtccc gaacagtaag gcagttccag ttcactgact ggccagagca aggagtgcca   4920

aagtccggag aaggatttat tgacttcatc ggccaagtcc ataaaacaaa agaacagttt   4980

ggccaagatg gacccatttc agtccattgc agcgcgggcg ttggaagaac tggagtcttc   5040

ataacgctaa gcattgtttt ggaaagaatg agatatgaag gagttgtaga tatcttccag   5100

actgtcaaaa tgttaagaac acaacgacca gctatggtac agacagagga tcaatatcag   5160

ttttcctatc gtgccgcact agagtacctg ggcagctttg accactatgc aacgtagaaa   5220

cccctgaccc attctggatt tttactacag gcccttcaat atccatggag tctcttctga   5280

gccatacagg gcacttgaga agtccttctt aacttctagc taacaactac ttagtgggac   5340

tattacacac aaaacaaatt aaaaacaaat tattccaggt ggaccaagaa ttcacagttt   5400

aataatctaa cctgaaaaat aatgaagaga atcctgactg atgaggcatc tgaaggattt   5460

tatttacaga tacctcaagg attcaaaatc aagggaagaa gaaatcacag caaagaacca   5520

ccatcttatt caggattgct tgaaaggtgc aaggagaaat tgccagaatg ctgcagttca   5580

gcacaagata tgtgctggtg tggcttctca caatgaaacg gactctgctt tgacatcgcc   5640

ccttcccacc atactgctca taataacatt ttagggggaa aggggaggga atgtttaaaa   5700

agaaagtcct tgatttagtt ttttagtatt gtaaagatac tgctgacctg tgcttcattt   5760

ctaactgtgt aaactttttt ttaacaaaat gtatcattcg ataaagtgaa ttttaaaaaa   5820

gttacataac tcttcatttt tttatttcca aatcgtaggt ttttttaagc tgtagaactg   5880

ttatctgtaa tatcttgctg tagaaatatc aaatcatttg aaaatttgca catttttgtg   5940

caaaactcaa tctacagtat cagtctcgtc agatatatta attttacact tcagttttga   6000

ttggtgagaa agtacccatt ctcttcaaat aatcaaagat aattattatt ttgttttgtt   6060

tttggaatca acagggaggc gcaaagtata aagttgctgc taacatatat acatatatat   6120

ccatatttta taagggtgtc tatgtatata tagacagtgt gtccacacaa aaaatagata   6180

cagttatcag tcagtcagtt cttccatgat ttagtttttt taaacgtaga aaagctattg   6240

taaacatctc tttccattta ttcttaattt tttgacatat tggtatttct ttaaagggaa   6300

atgaggaatg cacatcagtg attgattgtc aaacctcacc ccctgatttc ctacctaatc   6360

tacccccacc taaccaatca atcacatcca caaattgttt tgtttgtttg ttagtcaggc   6420

ttccaacaaa gttcaatatt tctaacactc tagtgcaata aaaattatta ttaaatagct   6480

aagaggtgtg catgtgggaa aggtcagtgc atatcccttt aggaggggag aatgttgtaa   6540

tatatcagct atcgagttgt ttaaaaaaag tgtattcaat cgtatattgt ctatagtatg   6600

tgctatgaaa tttgcattta tgatatgtaa caggggcaaa gccaaattca tgttactctg   6660

ttcagtcaga aacattttgt ggcatacagc attcctggga agtgctgtac tttgtttcgt   6720

tttggtttta gttttgcatt tagagtgcct tataattgat gcctatttta atagcatttc   6780

tttttagctt ttggttcgta tttccattca ctgttcgtat ctgttacttt ctattaaagc   6840

attatctgtt taccacatgt acaaaaactc tttgaataat atgcattcct agttttcagc   6900

caagtcgggg atgttagtga ttgtaccagc ccaaagcact tggataatca gggcccttct   6960

tccttttata atcaatcatc aacatcagaa aaagctactt gttttattta tattcccttc   7020

caaatccgct ctggaacatg cagtaactgc accaaactta ttttagtaac aaatatcatt   7080

ggcaactttg gaatatattt gatattccat taggattttt ctaaaagggg aaataaacta   7140

tatatatata tgtatcttac ccccaattct tccaacagaa tttctatagg aagccatgga   7200

tgatggcata agtttgccac atattacatg attttaaata atcctcaaaa tacccaagga   7260

actcttaaag agttttggta tgagtatact actttggttt aattttagct tcatggatgt   7320

tctgcatgga aggatttttg ttttccacat tttcccattg ctagcagagt gaaatccaag   7380

agaccaaaca tttgcaagca ttgtatttga gcacttttgt aaaaaacaaa gaaaaagaaa   7440

aaaaagaaaa tatatataat actaaaaaaa agtatctaga aggctacctc agaatgagac   7500

tctctaacct acatcagaac cagagaagaa tgtgcactat gtgggtctgt tatcattatt   7560

ttcttttagt ttgtatcttt ttggagattt atccaagtgc cagattactc agtgctataa   7620

ttttctttta gttaaacaaa gggggtcaga cagacattgc atcatccaga catgccttgt   7680

tggacatgta gaatccgatg gagcactgca caccagaatg attggccaat gagcagcttc   7740

tctccctgaa acaataactg cccatttggc aaagggaaag atgacaataa tcagaagaag   7800

aaaatgaatg ggatgcatac catagacgaa cgaggcggag actattgcgg gaatcttact   7860

gttcaggagc tgttcctaga actaactccc ttactgtcat tgatgtgcat tccactctgt   7920

gcttttctgt acaaccattc aagttttaat ttcccaggtg aaccatcttt atctgccatt   7980

accacaagct ttcaagtttc cagttatttt catcatcata accagtacgg tgctattatt   8040

tacctatgta cgtgtagtta tgtataattt tgtaattagt tacaatggta aaaaaaatca   8100

aaatatataa aaagtgattt gtacagaact ttattttagc tcttttttaa aaatgatttg   8160

catggttaga aaacggcgag gacagccagg ggagggaagg gcctctaggg aactttgcac   8220

tttctatacc tttgtactat gcactgccct attgattcta cacccaataa tgatattact   8280

tgaacccatc tgtaagaaac tgcttcggaa attcatttgt gtgtatgtaa ataacacaac   8340

atagaaacag gaagggaaaa aagtctgcag taatgcacgt attttttttc tttcctgttt   8400

attttcggtt ttgctttaag tccttttatt tttaattccc tttttgtttt tctttttggg   8460

ttttggttcc ttttgggttt atgggtgccc tgatactcca gcagagatca gaaggctaca   8520

gatccattct atccatccgt tatgtggctt tgccatccca gcttggagtg tctttacaaa   8580

gataataaca gttgtgttct ttgctctcgt tttggatgca tagactgaaa aattaaaaca   8640

aataacttgt aaaatggctt gttaaaaaat acaattacct ctaattagta gtacgcgtaa   8700

atgttttaca gaatgaaagg cgtgcttttt attttcttac ttcgttacat tggtggcgaa   8760

agaagtctgt atgaaaatca gttctttgct gacacaagtt ccatttgtta caaatgaatt   8820

ctaataaaaa tgtcagtgtt atgca                                         8845


<210>  595
<211>  1501
<212>  PRT
<213>  Homo sapiens

<400>  595

Met Val His Val Ala Arg Leu Leu Leu Leu Leu Leu Thr Phe Phe Leu 
1               5                   10                  15


Arg Thr Asp Ala Glu Thr Pro Pro Arg Phe Thr Arg Thr Pro Val Asp 
            20                  25                  30


Gln Thr Gly Val Ser Gly Gly Val Ala Ser Phe Ile Cys Gln Ala Thr 
        35                  40                  45


Gly Asp Pro Arg Pro Lys Ile Val Trp Asn Lys Lys Gly Lys Lys Val 
    50                  55                  60


Ser Asn Gln Arg Phe Glu Val Ile Glu Phe Asp Asp Gly Ser Gly Ser 
65                  70                  75                  80


Val Leu Arg Ile Gln Pro Leu Arg Thr Pro Arg Asp Glu Ala Ile Tyr 
                85                  90                  95


Glu Cys Val Ala Ser Asn Asn Val Gly Glu Ile Ser Val Ser Thr Arg 
            100                 105                 110


Leu Thr Val Leu Arg Glu Asp Gln Ile Pro Arg Gly Phe Pro Thr Ile 
        115                 120                 125


Asp Met Gly Pro Gln Leu Lys Val Val Glu Arg Thr Arg Thr Ala Thr 
    130                 135                 140


Met Leu Cys Ala Ala Ser Gly Asn Pro Asp Pro Glu Ile Thr Trp Phe 
145                 150                 155                 160


Lys Asp Phe Leu Pro Val Asp Thr Ser Asn Asn Asn Gly Arg Ile Lys 
                165                 170                 175


Gln Leu Arg Ser Glu Ser Ile Gly Gly Thr Pro Ile Arg Gly Ala Leu 
            180                 185                 190


Gln Ile Glu Gln Ser Glu Glu Ser Asp Gln Gly Lys Tyr Glu Cys Val 
        195                 200                 205


Ala Thr Asn Ser Ala Gly Thr Arg Tyr Ser Ala Pro Ala Asn Leu Tyr 
    210                 215                 220


Val Arg Glu Leu Arg Glu Val Arg Arg Val Pro Pro Arg Phe Ser Ile 
225                 230                 235                 240


Pro Pro Thr Asn His Glu Ile Met Pro Gly Gly Ser Val Asn Ile Thr 
                245                 250                 255


Cys Val Ala Val Gly Ser Pro Met Pro Tyr Val Lys Trp Met Leu Gly 
            260                 265                 270


Ala Glu Asp Leu Thr Pro Glu Asp Asp Met Pro Ile Gly Arg Asn Val 
        275                 280                 285


Leu Glu Leu Asn Asp Val Arg Gln Ser Ala Asn Tyr Thr Cys Val Ala 
    290                 295                 300


Met Ser Thr Leu Gly Val Ile Glu Ala Ile Ala Gln Ile Thr Val Lys 
305                 310                 315                 320


Ala Leu Pro Lys Pro Pro Gly Thr Pro Val Val Thr Glu Ser Thr Ala 
                325                 330                 335


Thr Ser Ile Thr Leu Thr Trp Asp Ser Gly Asn Pro Glu Pro Val Ser 
            340                 345                 350


Tyr Tyr Ile Ile Gln His Lys Pro Lys Asn Ser Glu Glu Leu Tyr Lys 
        355                 360                 365


Glu Ile Asp Gly Val Ala Thr Thr Arg Tyr Ser Val Ala Gly Leu Ser 
    370                 375                 380


Pro Tyr Ser Asp Tyr Glu Phe Arg Val Val Ala Val Asn Asn Ile Gly 
385                 390                 395                 400


Arg Gly Pro Pro Ser Glu Pro Val Leu Thr Gln Thr Ser Glu Gln Ala 
                405                 410                 415


Pro Ser Ser Ala Pro Arg Asp Val Gln Ala Arg Met Leu Ser Ser Thr 
            420                 425                 430


Thr Ile Leu Val Gln Trp Lys Glu Pro Glu Glu Pro Asn Gly Gln Ile 
        435                 440                 445


Gln Gly Tyr Arg Val Tyr Tyr Thr Met Asp Pro Thr Gln His Val Asn 
    450                 455                 460


Asn Trp Met Lys His Asn Val Ala Asp Ser Gln Ile Thr Thr Ile Gly 
465                 470                 475                 480


Asn Leu Val Pro Gln Lys Thr Tyr Ser Val Lys Val Leu Ala Phe Thr 
                485                 490                 495


Ser Ile Gly Asp Gly Pro Leu Ser Ser Asp Ile Gln Val Ile Thr Gln 
            500                 505                 510


Thr Gly Val Pro Gly Gln Pro Leu Asn Phe Lys Ala Glu Pro Glu Ser 
        515                 520                 525


Glu Thr Ser Ile Leu Leu Ser Trp Thr Pro Pro Arg Ser Asp Thr Ile 
    530                 535                 540


Ala Asn Tyr Glu Leu Val Tyr Lys Asp Gly Glu His Gly Glu Glu Gln 
545                 550                 555                 560


Arg Ile Thr Ile Glu Pro Gly Thr Ser Tyr Arg Leu Gln Gly Leu Lys 
                565                 570                 575


Pro Asn Ser Leu Tyr Tyr Phe Arg Leu Ala Ala Arg Ser Pro Gln Gly 
            580                 585                 590


Leu Gly Ala Ser Thr Ala Glu Ile Ser Ala Arg Thr Met Gln Ser Met 
        595                 600                 605


Phe Ala Lys Asn Phe His Val Lys Ala Val Met Lys Thr Ser Val Leu 
    610                 615                 620


Leu Ser Trp Glu Ile Pro Glu Asn Tyr Asn Ser Ala Met Pro Phe Lys 
625                 630                 635                 640


Ile Leu Tyr Asp Asp Gly Lys Met Val Glu Glu Val Asp Gly Arg Ala 
                645                 650                 655


Thr Gln Lys Leu Ile Val Asn Leu Lys Pro Glu Lys Ser Tyr Ser Phe 
            660                 665                 670


Val Leu Thr Asn Arg Gly Asn Ser Ala Gly Gly Leu Gln His Arg Val 
        675                 680                 685


Thr Ala Lys Thr Ala Pro Asp Val Leu Arg Thr Lys Pro Ala Phe Ile 
    690                 695                 700


Gly Lys Thr Asn Leu Asp Gly Met Ile Thr Val Gln Leu Pro Glu Val 
705                 710                 715                 720


Pro Ala Asn Glu Asn Ile Lys Gly Tyr Tyr Ile Ile Ile Val Pro Leu 
                725                 730                 735


Lys Lys Ser Arg Gly Lys Phe Ile Lys Pro Trp Glu Ser Pro Asp Glu 
            740                 745                 750


Met Glu Leu Asp Glu Leu Leu Lys Glu Ile Ser Arg Lys Arg Arg Ser 
        755                 760                 765


Ile Arg Tyr Gly Arg Glu Val Glu Leu Lys Pro Tyr Ile Ala Ala His 
    770                 775                 780


Phe Asp Val Leu Pro Thr Glu Phe Thr Leu Gly Asp Asp Lys His Tyr 
785                 790                 795                 800


Gly Gly Phe Thr Asn Lys Gln Leu Gln Ser Gly Gln Glu Tyr Val Phe 
                805                 810                 815


Phe Val Leu Ala Val Met Glu His Ala Glu Ser Lys Met Tyr Ala Thr 
            820                 825                 830


Ser Pro Tyr Ser Asp Pro Val Val Ser Met Asp Leu Asp Pro Gln Pro 
        835                 840                 845


Ile Thr Asp Glu Glu Glu Gly Leu Ile Trp Val Val Gly Pro Val Leu 
    850                 855                 860


Ala Val Val Phe Ile Ile Cys Ile Val Ile Ala Ile Leu Leu Tyr Lys 
865                 870                 875                 880


Arg Lys Arg Ala Glu Ser Asp Ser Arg Lys Ser Ser Ile Pro Asn Asn 
                885                 890                 895


Lys Glu Ile Pro Ser His His Pro Thr Asp Pro Val Glu Leu Arg Arg 
            900                 905                 910


Leu Asn Phe Gln Thr Pro Gly Met Ala Ser His Pro Pro Ile Pro Ile 
        915                 920                 925


Leu Glu Leu Ala Asp His Ile Glu Arg Leu Lys Ala Asn Asp Asn Leu 
    930                 935                 940


Lys Phe Ser Gln Glu Tyr Glu Ser Ile Asp Pro Gly Gln Gln Phe Thr 
945                 950                 955                 960


Trp Glu His Ser Asn Leu Glu Val Asn Lys Pro Lys Asn Arg Tyr Ala 
                965                 970                 975


Asn Val Ile Ala Tyr Asp His Ser Arg Val Leu Leu Ser Ala Ile Glu 
            980                 985                 990


Gly Ile Pro Gly Ser Asp Tyr Val Asn Ala Asn Tyr Ile Asp Gly Tyr 
        995                 1000                1005


Arg Lys Gln Asn Ala Tyr Ile Ala Thr Gln Gly Ser Leu Pro Glu Thr 
    1010                1015                1020


Phe Gly Asp Phe Trp Arg Met Ile Trp Glu Gln Arg Ser Ala Thr Val 
1025                1030                1035                1040


Val Met Met Thr Lys Leu Glu Glu Arg Ser Arg Val Lys Cys Asp Gln 
                1045                1050                1055


Tyr Trp Pro Ser Arg Gly Thr Glu Thr His Gly Leu Val Gln Val Thr 
            1060                1065                1070


Leu Leu Asp Thr Val Glu Leu Ala Thr Tyr Cys Val Arg Thr Phe Ala 
        1075                1080                1085


Leu Tyr Lys Asn Gly Ser Ser Glu Lys Arg Glu Val Arg Gln Phe Gln 
    1090                1095                1100


Phe Thr Ala Trp Pro Asp His Gly Val Pro Glu His Pro Thr Pro Phe 
1105                1110                1115                1120


Leu Ala Phe Leu Arg Arg Val Lys Thr Cys Asn Pro Pro Asp Ala Gly 
                1125                1130                1135


Pro Met Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Cys Phe 
            1140                1145                1150


Ile Val Ile Asp Ala Met Leu Glu Arg Ile Lys His Glu Lys Thr Val 
        1155                1160                1165


Asp Ile Tyr Gly His Val Thr Leu Met Arg Ala Gln Arg Asn Tyr Met 
    1170                1175                1180


Val Gln Thr Glu Asp Gln Tyr Ile Phe Ile His Asp Ala Leu Leu Glu 
1185                1190                1195                1200


Ala Val Thr Cys Gly Asn Thr Glu Val Pro Ala Arg Asn Leu Tyr Ala 
                1205                1210                1215


Tyr Ile Gln Lys Leu Thr Gln Ile Glu Thr Gly Glu Asn Val Thr Gly 
            1220                1225                1230


Met Glu Leu Glu Phe Lys Arg Leu Ala Ser Ser Lys Ala His Thr Ser 
        1235                1240                1245


Arg Phe Ile Ser Ala Asn Leu Pro Cys Asn Lys Phe Lys Asn Arg Leu 
    1250                1255                1260


Val Asn Ile Met Pro Tyr Glu Ser Thr Arg Val Cys Leu Gln Pro Ile 
1265                1270                1275                1280


Arg Gly Val Glu Gly Ser Asp Tyr Ile Asn Ala Ser Phe Ile Asp Gly 
                1285                1290                1295


Tyr Arg Gln Gln Lys Ala Tyr Ile Ala Thr Gln Gly Pro Leu Ala Glu 
            1300                1305                1310


Thr Thr Glu Asp Phe Trp Arg Met Leu Trp Glu His Asn Ser Thr Ile 
        1315                1320                1325


Val Val Met Leu Thr Lys Leu Arg Glu Met Gly Arg Glu Lys Cys His 
    1330                1335                1340


Gln Tyr Trp Pro Ala Glu Arg Ser Ala Arg Tyr Gln Tyr Phe Val Val 
1345                1350                1355                1360


Asp Pro Met Ala Glu Tyr Asn Met Pro Gln Tyr Ile Leu Arg Glu Phe 
                1365                1370                1375


Lys Val Thr Asp Ala Arg Asp Gly Gln Ser Arg Thr Val Arg Gln Phe 
            1380                1385                1390


Gln Phe Thr Asp Trp Pro Glu Gln Gly Val Pro Lys Ser Gly Glu Gly 
        1395                1400                1405


Phe Ile Asp Phe Ile Gly Gln Val His Lys Thr Lys Glu Gln Phe Gly 
    1410                1415                1420


Gln Asp Gly Pro Ile Ser Val His Cys Ser Ala Gly Val Gly Arg Thr 
1425                1430                1435                1440


Gly Val Phe Ile Thr Leu Ser Ile Val Leu Glu Arg Met Arg Tyr Glu 
                1445                1450                1455


Gly Val Val Asp Ile Phe Gln Thr Val Lys Met Leu Arg Thr Gln Arg 
            1460                1465                1470


Pro Ala Met Val Gln Thr Glu Asp Gln Tyr Gln Phe Ser Tyr Arg Ala 
        1475                1480                1485


Ala Leu Glu Tyr Leu Gly Ser Phe Asp His Tyr Ala Thr 
    1490                1495                1500


<210>  596
<211>  2300
<212>  DNA
<213>  Homo sapiens

<400>  596
ctctgccagg ctcacgggac agctgcacct ctcagcgtct ccagctccag gacgcggtcg     60

tcccaactcc ttccgagtgg aaagagtgta aaacttttgt ccgtgcgcgg gtggagctca    120

gtaggaccac ggcgcgtcct gccccggctt ccccagcctc ccagcagggt tagctgcggt    180

cagcgcactt tccacttggg actcccggcc agaaatttct cgggaatgga gcggtcacag    240

tgtggcagca gagaccgagg cgttagcggc cgacctcact tggcccctgg gctagtggtg    300

gctgcccctc cgcccccgtc cccggcgttg ccggtaccat cggggatgca ggttccccca    360

gcgttcctgc ggccgcccag cctctttctg cgagcagcgg ccgcggccgc cgccgccgct    420

gccgccacct cgggaagcgg aggctgcccg ccggctcccg ggctggagag cggggtaggc    480

gcggtgggct gcggctaccc gcggacgccc aagtgcgccc gctgtcgtaa ccatggtgtg    540

gtgtcagcgc tcaagggcca caagcgcttc tgccgctggc gggactgcgc gtgtgccaag    600

tgcaccctga tcgccgagcg ccagcgcgtc atggccgccc aggtggcgct gcgcaggcag    660

caggcgcagg aggagagcga agctcggggg ctacagaggc tcctgtgctc ggggctctcc    720

tggccccccg gtggtcgggc atccgggggc ggcggcagag ccgagaatcc acagtccacg    780

ggcggccctg cggcgggggc tgcgctggga ctgggtgcct tgagacaggc cagtggttcc    840

gcgacccccg ctttcgaatt tttccagcaa gattatcctg aggaaaaaca agaacaaaaa    900

gagagtaaat gtgagtcatg ccagaatgga caagaagaac tgatctccaa atcccatcag    960

ctttacctag gatcatcttc taggtctaat ggtgtcattg ggaaacaaag tatcgggtca   1020

tctatttcag aatactccaa caagcctgat agtatcctgt ctcctcatcc tggagagcaa   1080

tcaggaggtg aagagagtcc caggtcctta tcatcctctg atctggaatc aggaaatgaa   1140

agtgaatggg tcaaagactt gacttcgacc aaggcaagcc ttccgacagt gtcctcaaga   1200

ccaagagatc ctcttgatat ccttactaag attttcccaa attacaggcg cagccggcta   1260

gaaggcattc tacggttctg caaaggggat gtggtccaag ccattgaaca ggttttaaat   1320

ggcaaagaac acaagccaga caacaggaac ctagcaaact cagaagaact ggaaaacaca   1380

gcctttcaga gagcttcaag ttttagtctt gctggaattg gttttggaac tctaggtaat   1440

aaatcagctt tctctcctct tcaaactact tctgcttctt atggaggtga ttcaagtctc   1500

tacggcgtaa atcctagagt aggtatcagt ccattaaggc tggcatattc ttctgcagga   1560

agagggttat ctggttttat gtcaccctac ctaacacctg ggttagtacc aaccttacct   1620

tttcggccag ctttggatta tgccttttca gggatgatta gagattcttc ctacctttcc   1680

agtaaagact caataacttg tggcagactg tacttcagac caaatcagga caatccgtaa   1740

tgtatatgcc cattctctct ttctggagtt tttccagcat acaatacatg cacgtgcaca   1800

cacatacaca cacatccatt aatatacttc agtaagtatg tgagtggatt atgaggtctt   1860

aaaatgctgg gttttttttt tcaagcaata taataggtct tagatctgaa aactcttcat   1920

taggatttat caagtgaaag aagtaaatct gaacattata tgtgccttga ataaagctat   1980

ttcaggaaat atttaatgaa ttttctccct aaattatcat ttgtaaacat ttttatttta   2040

aaactagttt ttattttatt gaaaagtgga atttttagtg ataaaataca tttgtaagtg   2100

taaagcaata cagcataata gaatagaata taaaccgaaa ggaagaactg aacaattaag   2160

gcaattctat ataattacca tttcaaaact gtttcttcta ttcctggttc ataggaaaga   2220

aaaaagttat tcaaagtatt tttaaagcat ttgatttgca gatgggtgat tcgtaataaa   2280

taaaacattt gagcattttg                                               2300


<210>  597
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  597

Met Glu Arg Ser Gln Cys Gly Ser Arg Asp Arg Gly Val Ser Gly Arg 
1               5                   10                  15


Pro His Leu Ala Pro Gly Leu Val Val Ala Ala Pro Pro Pro Pro Ser 
            20                  25                  30


Pro Ala Leu Pro Val Pro Ser Gly Met Gln Val Pro Pro Ala Phe Leu 
        35                  40                  45


Arg Pro Pro Ser Leu Phe Leu Arg Ala Ala Ala Ala Ala Ala Ala Ala 
    50                  55                  60


Ala Ala Ala Thr Ser Gly Ser Gly Gly Cys Pro Pro Ala Pro Gly Leu 
65                  70                  75                  80


Glu Ser Gly Val Gly Ala Val Gly Cys Gly Tyr Pro Arg Thr Pro Lys 
                85                  90                  95


Cys Ala Arg Cys Arg Asn His Gly Val Val Ser Ala Leu Lys Gly His 
            100                 105                 110


Lys Arg Phe Cys Arg Trp Arg Asp Cys Ala Cys Ala Lys Cys Thr Leu 
        115                 120                 125


Ile Ala Glu Arg Gln Arg Val Met Ala Ala Gln Val Ala Leu Arg Arg 
    130                 135                 140


Gln Gln Ala Gln Glu Glu Ser Glu Ala Arg Gly Leu Gln Arg Leu Leu 
145                 150                 155                 160


Cys Ser Gly Leu Ser Trp Pro Pro Gly Gly Arg Ala Ser Gly Gly Gly 
                165                 170                 175


Gly Arg Ala Glu Asn Pro Gln Ser Thr Gly Gly Pro Ala Ala Gly Ala 
            180                 185                 190


Ala Leu Gly Leu Gly Ala Leu Arg Gln Ala Ser Gly Ser Ala Thr Pro 
        195                 200                 205


Ala Phe Glu Phe Phe Gln Gln Asp Tyr Pro Glu Glu Lys Gln Glu Gln 
    210                 215                 220


Lys Glu Ser Lys Cys Glu Ser Cys Gln Asn Gly Gln Glu Glu Leu Ile 
225                 230                 235                 240


Ser Lys Ser His Gln Leu Tyr Leu Gly Ser Ser Ser Arg Ser Asn Gly 
                245                 250                 255


Val Ile Gly Lys Gln Ser Ile Gly Ser Ser Ile Ser Glu Tyr Ser Asn 
            260                 265                 270


Lys Pro Asp Ser Ile Leu Ser Pro His Pro Gly Glu Gln Ser Gly Gly 
        275                 280                 285


Glu Glu Ser Pro Arg Ser Leu Ser Ser Ser Asp Leu Glu Ser Gly Asn 
    290                 295                 300


Glu Ser Glu Trp Val Lys Asp Leu Thr Ser Thr Lys Ala Ser Leu Pro 
305                 310                 315                 320


Thr Val Ser Ser Arg Pro Arg Asp Pro Leu Asp Ile Leu Thr Lys Ile 
                325                 330                 335


Phe Pro Asn Tyr Arg Arg Ser Arg Leu Glu Gly Ile Leu Arg Phe Cys 
            340                 345                 350


Lys Gly Asp Val Val Gln Ala Ile Glu Gln Val Leu Asn Gly Lys Glu 
        355                 360                 365


His Lys Pro Asp Asn Arg Asn Leu Ala Asn Ser Glu Glu Leu Glu Asn 
    370                 375                 380


Thr Ala Phe Gln Arg Ala Ser Ser Phe Ser Leu Ala Gly Ile Gly Phe 
385                 390                 395                 400


Gly Thr Leu Gly Asn Lys Ser Ala Phe Ser Pro Leu Gln Thr Thr Ser 
                405                 410                 415


Ala Ser Tyr Gly Gly Asp Ser Ser Leu Tyr Gly Val Asn Pro Arg Val 
            420                 425                 430


Gly Ile Ser Pro Leu Arg Leu Ala Tyr Ser Ser Ala Gly Arg Gly Leu 
        435                 440                 445


Ser Gly Phe Met Ser Pro Tyr Leu Thr Pro Gly Leu Val Pro Thr Leu 
    450                 455                 460


Pro Phe Arg Pro Ala Leu Asp Tyr Ala Phe Ser Gly Met Ile Arg Asp 
465                 470                 475                 480


Ser Ser Tyr Leu Ser Ser Lys Asp Ser Ile Thr Cys Gly Arg Leu Tyr 
                485                 490                 495


Phe Arg Pro Asn Gln Asp Asn Pro 
            500


<210>  598
<211>  2792
<212>  DNA
<213>  Homo sapiens

<400>  598
aatttagaga agatgtaggg agtgttcaac atgttcgttg tggaagagaa agagctaaga     60

gagaggagct taaagacaca aacgggtaga atcaaggagt gtgctctcaa atgagaggaa    120

caggagtgac attaaccttg aaatgctcgg agactctact ccttcatgac agtaggagga    180

taattaacaa tagatacaaa tgcaggaatt gatgagtgcc atcagaaagc tgtatcatga    240

gctgcctgca cttctaaagt gtccagtgga tttttaatca catgagcctg gaaatagggt    300

tatgaaaaga agctcagagc agagcaccga aagtggccac taccagcatg aagagcccaa    360

caattcaaac tggtgaagtg agaaaaacag aatgcagctt tcaaggttcg tttcaagcag    420

ttggcttgtg ggactctgag agatgctgct gcccatgaca tgcgggaatt atcatgatca    480

actacccagc ttggatttca tccagtggcc aagagctttg tgtgggagac ggcaagggtt    540

ggatttttca aaagagtaaa ccaggataaa tcatgaggaa cctataaccc ttttggccac    600

atgcaaaaaa gcaagacccg tgaccaaggt gtagactaag aagtggagtc atgcttcaca    660

cggccatatc atgctggcag ccattcctgg gtctggctgt ggtgttaatc ttcatgggat    720

ccaccattgg ctgccccgct cgctgtgagt gctctgccca gaacaaatct gttagctgtc    780

acagaaggcg attgatcgcc atcccagagg gcattcccat cgaaaccaaa atcttggacc    840

tcagtaaaaa caggctaaaa agcgtcaacc ctgaagaatt catatcatat cctctgctgg    900

aagagataga cttgagtgac aacatcattg ccaatgtgga accaggagca ttcaacaatc    960

tctttaacct gcgttccctc cgcctaaaag gcaatcgtct aaagctggtc cctttgggag   1020

tattcacggg gctgtccaat ctcactaagc ttgacattag tgagaataag attgtcattt   1080

tactagacta catgttccaa gatctacata acctgaagtc tctagaagtg ggggacaatg   1140

atttggttta tatatcacac agggcattca gtgggcttct tagcttggag cagctcaccc   1200

tggagaaatg caacttaaca gcagtaccaa cagaagccct ctcccacctc cgcagcctca   1260

tcagcctgca tctgaagcat ctcaatatca acaatatgcc tgtgtatgcc tttaaaagat   1320

tgttccacct gaaacaccta gagattgact attggccttt actggatatg atgcctgcca   1380

atagcctcta cggtctcaac ctcacatccc tttcagtcac caacaccaat ctgtctactg   1440

tacccttcct tgcctttaaa cacctggtat acctgactca ccttaacctc tcctacaatc   1500

ccatcagcac tattgaagca ggcatgttct ctgacctgat ccgccttcag gagcttcata   1560

tagtgggggc ccagcttcgc accattgagc ctcactcctt ccaagggctc cgcttcctac   1620

gcgtgctcaa tgtgtctcag aacctgctgg aaactttgga agagaatgtc ttctcctccc   1680

ctagggctct ggaggtcttg agcattaaca acaaccctct ggcctgtgac tgccgccttc   1740

tctggatctt gcagcgacag cccaccctgc agtttggtgg ccagcaacct atgtgtgctg   1800

gcccagacac catccgtgag aggtctttca aggatttcca tagcactgcc ctttcttttt   1860

actttacctg caaaaaaccc aaaatccgtg aaaagaagtt gcagcatctg ctagtagatg   1920

aagggcagac agtccagcta gaatgcagtg cagatggaga cccgcagcct gtgatttcct   1980

gggtgacacc ccgaaggcgt ttcatcacca ccaagtccaa tggaagagcc accgtgttgg   2040

gtgatggcac cttggaaatc cgctttgccc aggatcaaga cagcgggatg tatgtttgca   2100

tcgctagcaa tgctgctggg aatgatacct tcacagcctc cttaactgtg aaaggattcg   2160

cttcagatcg ttttctttat gcgaacagga cccctatgta catgaccgac tccaatgaca   2220

ccatttccaa tggcaccaat gccaatactt tttccctgga ccttaaaaca atactggtgt   2280

ctacagctat gggctgcttc acattcctgg gagtggtttt attttgtttt cttctccttt   2340

ttgtgtggag ccgagggaaa ggcaagcaca aaaacagcat tgaccttgag tatgtgccca   2400

gaaaaaacaa tggtgctgtt gtggaaggag aggtagctgg acccaggagg ttcaacatga   2460

aaatgatttg aaggcccacc cctcacatta ctgtctcttt gtcaatgtgg gtaatcagta   2520

agacagtatg gcacagtaaa ttactagatt aagaggcagc catgtgcagc tgcccctgta   2580

tcaaaagcag ggtctatgga agcaggagga cttccaatgg agactctcca tcgaaaggca   2640

ggcaggcagg catgtgtcag agcccttcac acagtgggat actaagtgtt tgcgttgcaa   2700

atattggcgt tctggggatc tcagtaatga acctgaatat ttggctcaca ctcacggaca   2760

attattcagc attttctacc actgcaaaaa ac                                 2792


<210>  599
<211>  606
<212>  PRT
<213>  Homo sapiens

<400>  599

Met Leu His Thr Ala Ile Ser Cys Trp Gln Pro Phe Leu Gly Leu Ala 
1               5                   10                  15


Val Val Leu Ile Phe Met Gly Ser Thr Ile Gly Cys Pro Ala Arg Cys 
            20                  25                  30


Glu Cys Ser Ala Gln Asn Lys Ser Val Ser Cys His Arg Arg Arg Leu 
        35                  40                  45


Ile Ala Ile Pro Glu Gly Ile Pro Ile Glu Thr Lys Ile Leu Asp Leu 
    50                  55                  60


Ser Lys Asn Arg Leu Lys Ser Val Asn Pro Glu Glu Phe Ile Ser Tyr 
65                  70                  75                  80


Pro Leu Leu Glu Glu Ile Asp Leu Ser Asp Asn Ile Ile Ala Asn Val 
                85                  90                  95


Glu Pro Gly Ala Phe Asn Asn Leu Phe Asn Leu Arg Ser Leu Arg Leu 
            100                 105                 110


Lys Gly Asn Arg Leu Lys Leu Val Pro Leu Gly Val Phe Thr Gly Leu 
        115                 120                 125


Ser Asn Leu Thr Lys Leu Asp Ile Ser Glu Asn Lys Ile Val Ile Leu 
    130                 135                 140


Leu Asp Tyr Met Phe Gln Asp Leu His Asn Leu Lys Ser Leu Glu Val 
145                 150                 155                 160


Gly Asp Asn Asp Leu Val Tyr Ile Ser His Arg Ala Phe Ser Gly Leu 
                165                 170                 175


Leu Ser Leu Glu Gln Leu Thr Leu Glu Lys Cys Asn Leu Thr Ala Val 
            180                 185                 190


Pro Thr Glu Ala Leu Ser His Leu Arg Ser Leu Ile Ser Leu His Leu 
        195                 200                 205


Lys His Leu Asn Ile Asn Asn Met Pro Val Tyr Ala Phe Lys Arg Leu 
    210                 215                 220


Phe His Leu Lys His Leu Glu Ile Asp Tyr Trp Pro Leu Leu Asp Met 
225                 230                 235                 240


Met Pro Ala Asn Ser Leu Tyr Gly Leu Asn Leu Thr Ser Leu Ser Val 
                245                 250                 255


Thr Asn Thr Asn Leu Ser Thr Val Pro Phe Leu Ala Phe Lys His Leu 
            260                 265                 270


Val Tyr Leu Thr His Leu Asn Leu Ser Tyr Asn Pro Ile Ser Thr Ile 
        275                 280                 285


Glu Ala Gly Met Phe Ser Asp Leu Ile Arg Leu Gln Glu Leu His Ile 
    290                 295                 300


Val Gly Ala Gln Leu Arg Thr Ile Glu Pro His Ser Phe Gln Gly Leu 
305                 310                 315                 320


Arg Phe Leu Arg Val Leu Asn Val Ser Gln Asn Leu Leu Glu Thr Leu 
                325                 330                 335


Glu Glu Asn Val Phe Ser Ser Pro Arg Ala Leu Glu Val Leu Ser Ile 
            340                 345                 350


Asn Asn Asn Pro Leu Ala Cys Asp Cys Arg Leu Leu Trp Ile Leu Gln 
        355                 360                 365


Arg Gln Pro Thr Leu Gln Phe Gly Gly Gln Gln Pro Met Cys Ala Gly 
    370                 375                 380


Pro Asp Thr Ile Arg Glu Arg Ser Phe Lys Asp Phe His Ser Thr Ala 
385                 390                 395                 400


Leu Ser Phe Tyr Phe Thr Cys Lys Lys Pro Lys Ile Arg Glu Lys Lys 
                405                 410                 415


Leu Gln His Leu Leu Val Asp Glu Gly Gln Thr Val Gln Leu Glu Cys 
            420                 425                 430


Ser Ala Asp Gly Asp Pro Gln Pro Val Ile Ser Trp Val Thr Pro Arg 
        435                 440                 445


Arg Arg Phe Ile Thr Thr Lys Ser Asn Gly Arg Ala Thr Val Leu Gly 
    450                 455                 460


Asp Gly Thr Leu Glu Ile Arg Phe Ala Gln Asp Gln Asp Ser Gly Met 
465                 470                 475                 480


Tyr Val Cys Ile Ala Ser Asn Ala Ala Gly Asn Asp Thr Phe Thr Ala 
                485                 490                 495


Ser Leu Thr Val Lys Gly Phe Ala Ser Asp Arg Phe Leu Tyr Ala Asn 
            500                 505                 510


Arg Thr Pro Met Tyr Met Thr Asp Ser Asn Asp Thr Ile Ser Asn Gly 
        515                 520                 525


Thr Asn Ala Asn Thr Phe Ser Leu Asp Leu Lys Thr Ile Leu Val Ser 
    530                 535                 540


Thr Ala Met Gly Cys Phe Thr Phe Leu Gly Val Val Leu Phe Cys Phe 
545                 550                 555                 560


Leu Leu Leu Phe Val Trp Ser Arg Gly Lys Gly Lys His Lys Asn Ser 
                565                 570                 575


Ile Asp Leu Glu Tyr Val Pro Arg Lys Asn Asn Gly Ala Val Val Glu 
            580                 585                 590


Gly Glu Val Ala Gly Pro Arg Arg Phe Asn Met Lys Met Ile 
        595                 600                 605


<210>  600
<211>  1060
<212>  DNA
<213>  Homo sapiens

<400>  600
ctattgatgg gcccaagcgt aaccaggctc ttctgattgg ccggtgtact tcagtttccg     60

tccaaggtcc gcctcctacc tccttctgct tcggggaggg catgggatca gctacctgtt    120

tctgcctcaa ccacggacca ataatatgag atctttgttc accagttcta cagtgatggg    180

gtgcttcctt ttggcttctg gaatgggtgc gtttgcttct gaggatctcc agtgtcacaa    240

caaacacatg ccagccctgt tttacaggga gccctggagg agttgggata gaggccacat    300

tgactgaggg tagttgccag ggtcctgcag ttatacacaa agtccttagg ataagaccat    360

ggccttgaga gcatgtggct tgatcatctt ccgaagatgc ctcattccca aagtggacaa    420

caatgcaatt gagtttttac tgctgcaggc atcagatggc attcatcact ggactcctcc    480

caaaggccat gtggaaccag gagaggatga cttggaaaca gccctgaggg agacccaaga    540

ggaagcaggc atagaagcag gccagctgac cattattgag gggttcaaaa gggaactcaa    600

ttatgtggcc aggaacaagc ctaaaacagt catttactgg ctggcggagg tgaaggacta    660

tgacgtggag atccgcctct cccatgagca ccaagcctac cgctggctgg ggctggagga    720

ggcctgccag ttggctcagt tcaaggagat gaaggcagcg ctccaagaag gacaccagtt    780

tctttgctcc atagaggcct gagctgactg gagcagagtc atttgcttca gcaggatcct    840

tgtgggcctt ctaagatgaa gccaccctca ggtccaggga aggttgtgct ggtatttggc    900

tcatgacagc caagagcaga tttgtgaaat cggctcaact cccaggtgag agcaagcaaa    960

aatcttggct gggtggaaag gaaggcaaaa gagtaaaaat taaaaaggcc aggcccagta   1020

agtgtacctt gtactttata aataaacctc aagcagctca                         1060


<210>  601
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  601

Met Ala Leu Arg Ala Cys Gly Leu Ile Ile Phe Arg Arg Cys Leu Ile 
1               5                   10                  15


Pro Lys Val Asp Asn Asn Ala Ile Glu Phe Leu Leu Leu Gln Ala Ser 
            20                  25                  30


Asp Gly Ile His His Trp Thr Pro Pro Lys Gly His Val Glu Pro Gly 
        35                  40                  45


Glu Asp Asp Leu Glu Thr Ala Leu Arg Glu Thr Gln Glu Glu Ala Gly 
    50                  55                  60


Ile Glu Ala Gly Gln Leu Thr Ile Ile Glu Gly Phe Lys Arg Glu Leu 
65                  70                  75                  80


Asn Tyr Val Ala Arg Asn Lys Pro Lys Thr Val Ile Tyr Trp Leu Ala 
                85                  90                  95


Glu Val Lys Asp Tyr Asp Val Glu Ile Arg Leu Ser His Glu His Gln 
            100                 105                 110


Ala Tyr Arg Trp Leu Gly Leu Glu Glu Ala Cys Gln Leu Ala Gln Phe 
        115                 120                 125


Lys Glu Met Lys Ala Ala Leu Gln Glu Gly His Gln Phe Leu Cys Ser 
    130                 135                 140


Ile Glu Ala 
145


<210>  602
<211>  989
<212>  DNA
<213>  Homo sapiens

<400>  602
ctattgatgg gcccaagcgt aaccaggctc ttctgattgg ccggtgtact tcagtttccg     60

tccaaggtcc gcctcctacc tccttctgct tcggttctac agtgatgggg tgcttccttt    120

tggcttctgg aatgggtgcg tttgcttctg aggatctcca gtgtcacaac aaacacatgc    180

cagccctgtt ttacagggag ccctggagga gttgggatag aggccacatt gactgagggt    240

agttgccagg gtcctgcagt tatacacaaa gtccttagga taagaccatg gccttgagag    300

catgtggctt gatcatcttc cgaagatgcc tcattcccaa agtggacaac aatgcaattg    360

agtttttact gctgcaggca tcagatggca ttcatcactg gactcctccc aaaggccatg    420

tggaaccagg agaggatgac ttggaaacag ccctgaggga gacccaagag gaagcaggca    480

tagaagcagg ccagctgacc attattgagg ggttcaaaag ggaactcaat tatgtggcca    540

ggaacaagcc taaaacagtc atttactggc tggcggaggt gaaggactat gacgtggaga    600

tccgcctctc ccatgagcac caagcctacc gctggctggg gctggaggag gcctgccagt    660

tggctcagtt caaggagatg aaggcagcgc tccaagaagg acaccagttt ctttgctcca    720

tagaggcctg agctgactgg agcagagtca tttgcttcag caggatcctt gtgggccttc    780

taagatgaag ccaccctcag gtccagggaa ggttgtgctg gtatttggct catgacagcc    840

aagagcagat ttgtgaaatc ggctcaactc ccaggtgaga gcaagcaaaa atcttggctg    900

ggtggaaagg aaggcaaaag agtaaaaatt aaaaaggcca ggcccagtaa gtgtaccttg    960

tactttataa ataaacctca agcagctca                                      989


<210>  603
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  603

Met Ala Leu Arg Ala Cys Gly Leu Ile Ile Phe Arg Arg Cys Leu Ile 
1               5                   10                  15


Pro Lys Val Asp Asn Asn Ala Ile Glu Phe Leu Leu Leu Gln Ala Ser 
            20                  25                  30


Asp Gly Ile His His Trp Thr Pro Pro Lys Gly His Val Glu Pro Gly 
        35                  40                  45


Glu Asp Asp Leu Glu Thr Ala Leu Arg Glu Thr Gln Glu Glu Ala Gly 
    50                  55                  60


Ile Glu Ala Gly Gln Leu Thr Ile Ile Glu Gly Phe Lys Arg Glu Leu 
65                  70                  75                  80


Asn Tyr Val Ala Arg Asn Lys Pro Lys Thr Val Ile Tyr Trp Leu Ala 
                85                  90                  95


Glu Val Lys Asp Tyr Asp Val Glu Ile Arg Leu Ser His Glu His Gln 
            100                 105                 110


Ala Tyr Arg Trp Leu Gly Leu Glu Glu Ala Cys Gln Leu Ala Gln Phe 
        115                 120                 125


Lys Glu Met Lys Ala Ala Leu Gln Glu Gly His Gln Phe Leu Cys Ser 
    130                 135                 140


Ile Glu Ala 
145


<210>  604
<211>  947
<212>  DNA
<213>  Homo sapiens

<400>  604
ctattgatgg gcccaagcgt aaccaggctc ttctgattgg ccggtgtact tcagtttccg     60

tccaaggtcc gcctcctacc tccttctgct tcggtgcgtt tgcttctgag gatctccagt    120

gtcacaacaa acacatgcca gccctgtttt acagggagcc ctggaggagt tgggatagag    180

gccacattga ctgagggtag ttgccagggt cctgcagtta tacacaaagt ccttaggata    240

agaccatggc cttgagagca tgtggcttga tcatcttccg aagatgcctc attcccaaag    300

tggacaacaa tgcaattgag tttttactgc tgcaggcatc agatggcatt catcactgga    360

ctcctcccaa aggccatgtg gaaccaggag aggatgactt ggaaacagcc ctgagggaga    420

cccaagagga agcaggcata gaagcaggcc agctgaccat tattgagggg ttcaaaaggg    480

aactcaatta tgtggccagg aacaagccta aaacagtcat ttactggctg gcggaggtga    540

aggactatga cgtggagatc cgcctctccc atgagcacca agcctaccgc tggctggggc    600

tggaggaggc ctgccagttg gctcagttca aggagatgaa ggcagcgctc caagaaggac    660

accagtttct ttgctccata gaggcctgag ctgactggag cagagtcatt tgcttcagca    720

ggatccttgt gggccttcta agatgaagcc accctcaggt ccagggaagg ttgtgctggt    780

atttggctca tgacagccaa gagcagattt gtgaaatcgg ctcaactccc aggtgagagc    840

aagcaaaaat cttggctggg tggaaaggaa ggcaaaagag taaaaattaa aaaggccagg    900

cccagtaagt gtaccttgta ctttataaat aaacctcaag cagctca                  947


<210>  605
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  605

Met Ala Leu Arg Ala Cys Gly Leu Ile Ile Phe Arg Arg Cys Leu Ile 
1               5                   10                  15


Pro Lys Val Asp Asn Asn Ala Ile Glu Phe Leu Leu Leu Gln Ala Ser 
            20                  25                  30


Asp Gly Ile His His Trp Thr Pro Pro Lys Gly His Val Glu Pro Gly 
        35                  40                  45


Glu Asp Asp Leu Glu Thr Ala Leu Arg Glu Thr Gln Glu Glu Ala Gly 
    50                  55                  60


Ile Glu Ala Gly Gln Leu Thr Ile Ile Glu Gly Phe Lys Arg Glu Leu 
65                  70                  75                  80


Asn Tyr Val Ala Arg Asn Lys Pro Lys Thr Val Ile Tyr Trp Leu Ala 
                85                  90                  95


Glu Val Lys Asp Tyr Asp Val Glu Ile Arg Leu Ser His Glu His Gln 
            100                 105                 110


Ala Tyr Arg Trp Leu Gly Leu Glu Glu Ala Cys Gln Leu Ala Gln Phe 
        115                 120                 125


Lys Glu Met Lys Ala Ala Leu Gln Glu Gly His Gln Phe Leu Cys Ser 
    130                 135                 140


Ile Glu Ala 
145


<210>  606
<211>  4205
<212>  DNA
<213>  Homo sapiens

<400>  606
acagagcccc gcgcggcgcg gcggcagctt cactctggtt caagcgcagg ggatcggcgg     60

gaagctcttt cacccccgct tctgccgggc tgtaactgca atggagcagg ttgagatgaa    120

ctcagtcaga tggccccacg gcccgctcct ttcttagcag cccactaatg ctccagaacc    180

ctcaggagaa gagccaggcc tacccccgcc gccgccggcc tggctgctac gcataccgtc    240

agaaccccga ggccatcgca gccgcagcta tgtacacctt cctgcccgac aacttctcac    300

ctgccaagcc caagccttcc aaagacctga agccgctgct gggctccgcg gttctggggc    360

tgctgcttgt gctggccgcg gtggtggcct ggtgctacta cagcgtctcc ctacgcaagg    420

cggagcgact tcgcgcggag ctgctggacc tgaaagctgg cggcttctcc atccgcaatc    480

agaagggaga gcaggtcttc cgcctggcct tccgctccgg cgcgctggac cttgactcct    540

gcagccgcga tggcgccctg ctgggctgct cgctcacggc cgacgggctg ccgctgcact    600

tcttcatcca gactgtgcgg cccaaggaca cggtcatgtg ctaccgcgtg cgctgggagg    660

aggcagcgcc gggccgggcc gtggagcacg ccatgttctt gggcgacgcg gcggcccact    720

ggtatggtgg cgccgagatg aggacgcaac actggcccat ccgcctggat ggccagcagg    780

agccccagcc gttcgtcacc agcgatgtct actcctccga cgccgcgttt gggggcatcc    840

tcgagcgcta ctggctatct tcgcgcgcgg ccgccatcaa agtcaatgac tcagtgccct    900

tccacctggg ctggaacagc acggagcgct cgctgcggct tcaggcgcgc taccacgaca    960

cgccctacaa gccacccgcc ggccgcgccg cagcgccaga gctgagctac cgagtgtgcg   1020

tgggctcaga cgtcacctcc atccacaagt acatggtgcg tcgctacttc aacaagccgt   1080

caagggtgcc agcacccgag gccttccgag accccatttg gtccacatgg gcgctgtacg   1140

ggcgcgccgt ggaccaggac aaggtgctgc gttttgccca acagatccgc ctgcaccact   1200

tcaacagcag ccacctggaa atcgacgaca tgtacacacc tgcttatggc gacttcgact   1260

tcgatgaggt caaattcccc aacgccagcg acatgttccg ccgcctgcgc gacgccggct   1320

tccgcgtcac gctctgggtg cacccttttg tcaactacaa ctcgtcgcgc ttcggcgagg   1380

gcgtggagcg cgagctgttc gtgcgcgaac ccacgggccg gttacctgcg ctggtgcgct   1440

ggtggaacgg catcggcgcg gtgctagact tcacgcaccc aaaggcccgc gactggttcc   1500

agggacacct gcggcggctg cgctctcgct actccgtggc ttccttcaag ttcgacgcgg   1560

gcgaggtcag ctacctgccg cgggacttca gcacctaccg gccgctgccg gaccccagcg   1620

tctggagccg gcgctacact gagatggcgc tgcccttctt ctcgctggcg gaggtgcgcg   1680

taggctacca gtcacagaac atctcctgct tcttccgcct ggtggatcgc gactctgtgt   1740

ggggctacga cctggggttg cgctcactca tccccgcggt gctcaccgtc agcatgctgg   1800

gctacccatt catcctaccc gatatggtgg gcggcaacgc cgtgccccag cggacagccg   1860

gcggcgatgt gcccgagcgc gagctctaca ttcgctggct ggaagtggcc gcctttatgc   1920

cggccatgca gttctctatc ccgccctggc gctacgacgc ggaagtggtg gccatcgcgc   1980

agaagttcgc cgccctgcgg gcctcgcttg tggcaccgct gttgcttgag ctggcgggcg   2040

aggtcaccga cacgggtgac cctatcgtgc gccccctttg gtggattgcg cccggcgacg   2100

agacagctca ccgtatcgac tcgcagttcc ttattgggga cacgctgctt gtggccccgg   2160

tgctggagcc aggcaagcag gagcgcgacg tctatttgcc cgccggcaag tggcgcagct   2220

acaagggtga gcttttcgac aagacgccgg tgctgctcac cgattacccg gtcgacctgg   2280

atgagatcgc ctactttacc tgggcgtcct gacccagccc agggcccggt aaccgcaaag   2340

cccccagtct tcatgcagac cttgaaccct ccgtcacacc cgcaccatgt actcccagga   2400

acctcccacc tctataccac ccattaagtg gctgctgact taaatgtgct ggaaccagct   2460

gctgaaggtg gggcctaggg agggggcact gaagcaatct cctgctccaa cgcacaatcc   2520

ttactgtgcc ctttccaccc ccacactcac accaatctgc agaaacctct tccctggggt   2580

ggaagccaga gagcttagag gaaaaaggtc agctctcttc ctgttataca tggttataca   2640

tggttggggt ttaaaagcac aaagagaaac ctccccctcc tggctttcgt ggccatcttt   2700

gtccatctta ggtggggact tgatcttatt taaggtctcc aaatagcccc caccacactt   2760

agaacgtgtg ttttcttagt gttagaagcc aggccctgag tccccagcac tcacctgaac   2820

tgtggctgat ttggtcccag tccagctggg gaggtgtttg gctgacaagg aggcaagaga   2880

tcccctccca gggaacagga ggactgggct tagcacagag ccatcatcat gttcccaatt   2940

tgtgaagaga ctcctaacac tgcactaacc catttgtgta catacatggg ctcagccctg   3000

ggccaaatgt gcctgatggg aacagacttg cagggccatg caggccagac ttcgtgcctt   3060

aactgaagag tgtgcgtgtg tgtgtgtgag agagagagag agagagaaac acgcatcatg   3120

ggtccctgat ctatgaaatg aacacaacct ctctgaggct ggatgatctg gaggaagggg   3180

gcatggagca aatttgaggc tctgattgct gagccagcct cctcccaggc ggtttcccca   3240

ggactctcgt aggaaataaa tagccctttc aagattcctc agctgcctca ccccctgcac   3300

atgtgcctgg ggtgtggcct agaagggagt gatgttctta ctctggtggt ctgtgcttct   3360

gaacacaggc tacatgcaca cactgacaac taccaataaa cagacagggg aaggtctttc   3420

atctcagcca ttttctcttc cccccgcccc cccttagatg gagtcttgct ctgtcaccca   3480

ggttggagtg cagtggcaca atcagctcac tgcaacccct cctcctaggt tcaagcgatt   3540

gagtagctga gattacaggc atgcatcact atgcctggct ttttgtattt tttagtagag   3600

atggggttta ccatgttggc caggctagtc tcaaactcct gacctagtga tgcacccacc   3660

ttggcctccc aaagtgttgg gattacaggc atgagccacc acgccagcca ttttctcttt   3720

ctaagaagag caacctcagc cggagtgagt tttttctgac tttgcagctg agtctggaga   3780

aaagtggcat gccagagcgg gtcggtggga aacagggtga actttagctt ccatcaacag   3840

ctctggtagc aaaaccagtc ccctaccccc tagagaatgc atccgtttcc ccacctgata   3900

tggtttggct gtgtccccac ctaaaactca tcttgaattg tagctcccat aattgccatg   3960

tgttgtggga aggacccagt gggagataat tgaaatatgg gggcagtttc cgccatactg   4020

ttctggtgat agtgaataga tctcatgaga gctgatgatt ttataagagg tttccccttt   4080

tgcttagttc tcattctctc ttgcctgccg ccatgtaaga cgtgcctttc tgtcatgctt   4140

gtgaggcctc cccagccacg tggagctgtg agttcattaa acctcttttt ctttataaat   4200

taaaa                                                               4205


<210>  607
<211>  714
<212>  PRT
<213>  Homo sapiens

<400>  607

Met Leu Gln Asn Pro Gln Glu Lys Ser Gln Ala Tyr Pro Arg Arg Arg 
1               5                   10                  15


Arg Pro Gly Cys Tyr Ala Tyr Arg Gln Asn Pro Glu Ala Ile Ala Ala 
            20                  25                  30


Ala Ala Met Tyr Thr Phe Leu Pro Asp Asn Phe Ser Pro Ala Lys Pro 
        35                  40                  45


Lys Pro Ser Lys Asp Leu Lys Pro Leu Leu Gly Ser Ala Val Leu Gly 
    50                  55                  60


Leu Leu Leu Val Leu Ala Ala Val Val Ala Trp Cys Tyr Tyr Ser Val 
65                  70                  75                  80


Ser Leu Arg Lys Ala Glu Arg Leu Arg Ala Glu Leu Leu Asp Leu Lys 
                85                  90                  95


Ala Gly Gly Phe Ser Ile Arg Asn Gln Lys Gly Glu Gln Val Phe Arg 
            100                 105                 110


Leu Ala Phe Arg Ser Gly Ala Leu Asp Leu Asp Ser Cys Ser Arg Asp 
        115                 120                 125


Gly Ala Leu Leu Gly Cys Ser Leu Thr Ala Asp Gly Leu Pro Leu His 
    130                 135                 140


Phe Phe Ile Gln Thr Val Arg Pro Lys Asp Thr Val Met Cys Tyr Arg 
145                 150                 155                 160


Val Arg Trp Glu Glu Ala Ala Pro Gly Arg Ala Val Glu His Ala Met 
                165                 170                 175


Phe Leu Gly Asp Ala Ala Ala His Trp Tyr Gly Gly Ala Glu Met Arg 
            180                 185                 190


Thr Gln His Trp Pro Ile Arg Leu Asp Gly Gln Gln Glu Pro Gln Pro 
        195                 200                 205


Phe Val Thr Ser Asp Val Tyr Ser Ser Asp Ala Ala Phe Gly Gly Ile 
    210                 215                 220


Leu Glu Arg Tyr Trp Leu Ser Ser Arg Ala Ala Ala Ile Lys Val Asn 
225                 230                 235                 240


Asp Ser Val Pro Phe His Leu Gly Trp Asn Ser Thr Glu Arg Ser Leu 
                245                 250                 255


Arg Leu Gln Ala Arg Tyr His Asp Thr Pro Tyr Lys Pro Pro Ala Gly 
            260                 265                 270


Arg Ala Ala Ala Pro Glu Leu Ser Tyr Arg Val Cys Val Gly Ser Asp 
        275                 280                 285


Val Thr Ser Ile His Lys Tyr Met Val Arg Arg Tyr Phe Asn Lys Pro 
    290                 295                 300


Ser Arg Val Pro Ala Pro Glu Ala Phe Arg Asp Pro Ile Trp Ser Thr 
305                 310                 315                 320


Trp Ala Leu Tyr Gly Arg Ala Val Asp Gln Asp Lys Val Leu Arg Phe 
                325                 330                 335


Ala Gln Gln Ile Arg Leu His His Phe Asn Ser Ser His Leu Glu Ile 
            340                 345                 350


Asp Asp Met Tyr Thr Pro Ala Tyr Gly Asp Phe Asp Phe Asp Glu Val 
        355                 360                 365


Lys Phe Pro Asn Ala Ser Asp Met Phe Arg Arg Leu Arg Asp Ala Gly 
    370                 375                 380


Phe Arg Val Thr Leu Trp Val His Pro Phe Val Asn Tyr Asn Ser Ser 
385                 390                 395                 400


Arg Phe Gly Glu Gly Val Glu Arg Glu Leu Phe Val Arg Glu Pro Thr 
                405                 410                 415


Gly Arg Leu Pro Ala Leu Val Arg Trp Trp Asn Gly Ile Gly Ala Val 
            420                 425                 430


Leu Asp Phe Thr His Pro Lys Ala Arg Asp Trp Phe Gln Gly His Leu 
        435                 440                 445


Arg Arg Leu Arg Ser Arg Tyr Ser Val Ala Ser Phe Lys Phe Asp Ala 
    450                 455                 460


Gly Glu Val Ser Tyr Leu Pro Arg Asp Phe Ser Thr Tyr Arg Pro Leu 
465                 470                 475                 480


Pro Asp Pro Ser Val Trp Ser Arg Arg Tyr Thr Glu Met Ala Leu Pro 
                485                 490                 495


Phe Phe Ser Leu Ala Glu Val Arg Val Gly Tyr Gln Ser Gln Asn Ile 
            500                 505                 510


Ser Cys Phe Phe Arg Leu Val Asp Arg Asp Ser Val Trp Gly Tyr Asp 
        515                 520                 525


Leu Gly Leu Arg Ser Leu Ile Pro Ala Val Leu Thr Val Ser Met Leu 
    530                 535                 540


Gly Tyr Pro Phe Ile Leu Pro Asp Met Val Gly Gly Asn Ala Val Pro 
545                 550                 555                 560


Gln Arg Thr Ala Gly Gly Asp Val Pro Glu Arg Glu Leu Tyr Ile Arg 
                565                 570                 575


Trp Leu Glu Val Ala Ala Phe Met Pro Ala Met Gln Phe Ser Ile Pro 
            580                 585                 590


Pro Trp Arg Tyr Asp Ala Glu Val Val Ala Ile Ala Gln Lys Phe Ala 
        595                 600                 605


Ala Leu Arg Ala Ser Leu Val Ala Pro Leu Leu Leu Glu Leu Ala Gly 
    610                 615                 620


Glu Val Thr Asp Thr Gly Asp Pro Ile Val Arg Pro Leu Trp Trp Ile 
625                 630                 635                 640


Ala Pro Gly Asp Glu Thr Ala His Arg Ile Asp Ser Gln Phe Leu Ile 
                645                 650                 655


Gly Asp Thr Leu Leu Val Ala Pro Val Leu Glu Pro Gly Lys Gln Glu 
            660                 665                 670


Arg Asp Val Tyr Leu Pro Ala Gly Lys Trp Arg Ser Tyr Lys Gly Glu 
        675                 680                 685


Leu Phe Asp Lys Thr Pro Val Leu Leu Thr Asp Tyr Pro Val Asp Leu 
    690                 695                 700


Asp Glu Ile Ala Tyr Phe Thr Trp Ala Ser 
705                 710


<210>  608
<211>  1184
<212>  DNA
<213>  Homo sapiens

<400>  608
aatgggcagt gcccatcctg gagggggcat cagtgtgggg tgggagcagg aaggctgttg     60

gggaaggaag ctgagagatc ctctgcagga ggggattata gcagctaagg gcacctgcca    120

ggctggaggt gtggcctgtc taggggaagg gtggtcactg atgtccagca ggagcccttg    180

acaggtagag cccaccacgg catctccaag accacaccat gttcctgttc tcccgtaaga    240

ccaggacccc tatcagtacc tacagtgact cctacagggc tcccacctcc atcaaggagg    300

tctataagga cccacccctg tgtgcctggg aagccaacaa gtttctgact ccgggtctga    360

ctcataccat ggagcgacat gtggatcccg aagccctgca gaagatggcc aaatgtgctg    420

tacaggacta cacttatagg gggtccatat caggccaccc ctacttgcct gagaagtact    480

ggctttctca agaggaagca gacaaatgca gcccaaacta cctgggcagt gactggtaca    540

acacatggag gatggaacct tacaacagca gctgctgcaa caagtatacc acctaccttc    600

ctcggctgcc taaggaggcc aggatggaga cagcagttcg aggaatgccc ttggaatgcc    660

ctcctaggcc ggagcggctc aatgcctacg agcgcgaagt gatggtgaac atgctgaact    720

cactgtcgcg gaaccagcag ctgccgcgga tcacgccccg atgcgggtgc gtggacccgc    780

tgcccggccg cctgcccttc catggttacg aaagtgcttg ctcgggccgc cactactgtc    840

tgcgcgggat ggactactac gccagcgggg cgccctgcac cgaccgccgc ctgcggcctt    900

ggtgccggga gcaaccgact atgtgtacct ccctacgagc accggcccgg aatgcagtgt    960

gctgttacaa ctcccccgcc gtcatactac ccatatccga accttagatg ggacacaagt   1020

cacttcaaga agtctggtgg tccccagaga aacaactatg ttatccatcc tgagtttgtg   1080

tctgagacct atcccgacta tcgttgctgg tagagcctgg gcttgctgtg ccaagggggc   1140

agagcaataa ataaactctt caaccccaaa aaaaaaaaaa aaaa                    1184


<210>  609
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  609

Met Phe Leu Phe Ser Arg Lys Thr Arg Thr Pro Ile Ser Thr Tyr Ser 
1               5                   10                  15


Asp Ser Tyr Arg Ala Pro Thr Ser Ile Lys Glu Val Tyr Lys Asp Pro 
            20                  25                  30


Pro Leu Cys Ala Trp Glu Ala Asn Lys Phe Leu Thr Pro Gly Leu Thr 
        35                  40                  45


His Thr Met Glu Arg His Val Asp Pro Glu Ala Leu Gln Lys Met Ala 
    50                  55                  60


Lys Cys Ala Val Gln Asp Tyr Thr Tyr Arg Gly Ser Ile Ser Gly His 
65                  70                  75                  80


Pro Tyr Leu Pro Glu Lys Tyr Trp Leu Ser Gln Glu Glu Ala Asp Lys 
                85                  90                  95


Cys Ser Pro Asn Tyr Leu Gly Ser Asp Trp Tyr Asn Thr Trp Arg Met 
            100                 105                 110


Glu Pro Tyr Asn Ser Ser Cys Cys Asn Lys Tyr Thr Thr Tyr Leu Pro 
        115                 120                 125


Arg Leu Pro Lys Glu Ala Arg Met Glu Thr Ala Val Arg Gly Met Pro 
    130                 135                 140


Leu Glu Cys Pro Pro Arg Pro Glu Arg Leu Asn Ala Tyr Glu Arg Glu 
145                 150                 155                 160


Val Met Val Asn Met Leu Asn Ser Leu Ser Arg Asn Gln Gln Leu Pro 
                165                 170                 175


Arg Ile Thr Pro Arg Cys Gly Cys Val Asp Pro Leu Pro Gly Arg Leu 
            180                 185                 190


Pro Phe His Gly Tyr Glu Ser Ala Cys Ser Gly Arg His Tyr Cys Leu 
        195                 200                 205


Arg Gly Met Asp Tyr Tyr Ala Ser Gly Ala Pro Cys Thr Asp Arg Arg 
    210                 215                 220


Leu Arg Pro Trp Cys Arg Glu Gln Pro Thr Met Cys Thr Ser Leu Arg 
225                 230                 235                 240


Ala Pro Ala Arg Asn Ala Val Cys Cys Tyr Asn Ser Pro Ala Val Ile 
                245                 250                 255


Leu Pro Ile Ser Glu Pro 
            260


<210>  610
<211>  726
<212>  DNA
<213>  Homo sapiens

<400>  610
tgacagccgc caacacagag ccctggagag gtggggagct gctgaagggc gggagaagtt     60

gcggcgtggc gataggtctg ggtgttctgg gaggacccct aaaagggagc agctctgcca    120

ggtcagagct tgaggtagca tgtgtgccgc ttccaggagg ccaggatgga gacagcagtt    180

cgaggaatgc ccttggaatg ccctcctagg ccggagcggc tcaatgccta cgagcgcgaa    240

gtgatggtga acatgctgaa ctcactgtcg cggaaccagc agctgccgcg gatcacgccc    300

cgatgcgggt gcgtggaccc gctgcccggc cgcctgccct tccatggtta cgaaagtgct    360

tgctcgggcc gccactactg tctgcgcggg atggactact acgccagcgg ggcgccctgc    420

accgaccgcc gcctgcggcc ttggtgccgg gagcaaccga ctatgtgtac ctccctacga    480

gcaccggccc ggaatgcagt gtgctgttac aactcccccg ccgtcatact acccatatcc    540

gaaccttaga tgggacacaa gtcacttcaa gaagtctggt ggtccccaga gaaacaacta    600

tgttatccat cctgagtttg tgtctgagac ctatcccgac tatcgttgct ggtagagcct    660

gggcttgctg tgccaagggg gcagagcaat aaataaactc ttcaacccca aaaaaaaaaa    720

aaaaaa                                                               726


<210>  611
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  611

Met Glu Thr Ala Val Arg Gly Met Pro Leu Glu Cys Pro Pro Arg Pro 
1               5                   10                  15


Glu Arg Leu Asn Ala Tyr Glu Arg Glu Val Met Val Asn Met Leu Asn 
            20                  25                  30


Ser Leu Ser Arg Asn Gln Gln Leu Pro Arg Ile Thr Pro Arg Cys Gly 
        35                  40                  45


Cys Val Asp Pro Leu Pro Gly Arg Leu Pro Phe His Gly Tyr Glu Ser 
    50                  55                  60


Ala Cys Ser Gly Arg His Tyr Cys Leu Arg Gly Met Asp Tyr Tyr Ala 
65                  70                  75                  80


Ser Gly Ala Pro Cys Thr Asp Arg Arg Leu Arg Pro Trp Cys Arg Glu 
                85                  90                  95


Gln Pro Thr Met Cys Thr Ser Leu Arg Ala Pro Ala Arg Asn Ala Val 
            100                 105                 110


Cys Cys Tyr Asn Ser Pro Ala Val Ile Leu Pro Ile Ser Glu Pro 
        115                 120                 125


<210>  612
<211>  578
<212>  DNA
<213>  Homo sapiens

<400>  612
tgacagccgc caacacagag ccctggagag gtggggagct gctgaagggc gggagaagtt     60

gcggcgtggc gataggtctg ggtgttctgg gaggacccct aaaagggagc agctctgcca    120

ggtcagagct tgaggtagca tgtgtgccgc ttccaggagg ccaggatgga gacagcagtt    180

cgaggaatgc ccttggaatg ccctcctagg ccggagcggc tcaatgccta cgagcgcgaa    240

gtgatggtga acatgctgaa ctcactgtcg cggaaccagc agctgccgcg gatcacgccc    300

cgatgcggat gtgtacctcc ctacgagcac cggcccggaa tgcagtgtgc tgttacaact    360

cccccgccgt catactaccc atatccgaac cttagatggg acacaagtca cttcaagaag    420

tctggtggtc cccagagaaa caactatgtt atccatcctg agtttgtgtc tgagacctat    480

cccgactatc gttgctggta gagcctgggc ttgctgtgcc aagggggcag agcaataaat    540

aaactcttca accccaaaaa aaaaaaaaaa aaaaaaaa                            578


<210>  613
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  613

Met Glu Thr Ala Val Arg Gly Met Pro Leu Glu Cys Pro Pro Arg Pro 
1               5                   10                  15


Glu Arg Leu Asn Ala Tyr Glu Arg Glu Val Met Val Asn Met Leu Asn 
            20                  25                  30


Ser Leu Ser Arg Asn Gln Gln Leu Pro Arg Ile Thr Pro Arg Cys Gly 
        35                  40                  45


Cys Val Pro Pro Tyr Glu His Arg Pro Gly Met Gln Cys Ala Val Thr 
    50                  55                  60


Thr Pro Pro Pro Ser Tyr Tyr Pro Tyr Pro Asn Leu Arg Trp Asp Thr 
65                  70                  75                  80


Ser His Phe Lys Lys Ser Gly Gly Pro Gln Arg Asn Asn Tyr Val Ile 
                85                  90                  95


His Pro Glu Phe Val Ser Glu Thr Tyr Pro Asp Tyr Arg Cys Trp 
            100                 105                 110


<210>  614
<211>  3641
<212>  DNA
<213>  Homo sapiens

<400>  614
gagtcaccgc agtggctgag ctgctgacag gaggcggcag cggagtagga ggcgaggcaa     60

gacctgcggc tcggcccggc cacagccgcg gtagtgctag gcaagcccac ggagtcacgc    120

cggcctcagc cagtctgcga acctctcgcc cccgcccacc cctgcatccg cccggcccct    180

gcccgcccga gtggtccggg gaggcctagt ctgcaccacc cgccgggctc ctggggccgc    240

cgccccgcgc ggtcctgtcg gcgtccgcgg ccgcgcccgg cccctggccc gctcgcccgc    300

cggcaccatg atggaggaga tcgaccggtt ccaggtgccc accgcgcact cggagatgca    360

gccgctggac ccagccgccg cctccatctc tgacggagac tgtgacgccc gggaggagaa    420

gcagcgggag ctggcccgga agggctccct gaagaatggc agcatgggta gccctgtcaa    480

ccagcaaccc aagaagaaca atgtcatggc ccgaacaagg ctggtcgtcc ccaataaagg    540

ctactcctca cttgaccaga gccctgatga gaagccactg gtagcccttg acacggacag    600

cgatgatgac tttgacatgt ctagatactc ctcctccggc tactcctctg ctgagcagat    660

caaccaagat ttgaacatcc agctgctgaa ggacggctac cggttagatg agatccccga    720

cgacgaggac ctagacctca tcccccccaa gtccgtgaac cccacgtgca tgtgctgcca    780

ggccacgtcc tccaccgcct gccacattca gtagcgggcg gggccactgc ggtcgccggg    840

gcggggccgc caagggccgg gtaggacggg cagaggccga ccccttccca gctcgtctgc    900

ctgcccccgg ccccgcgccc ctacagccgc caacctcgta taacagtcat tgcttcctcc    960

tatggtagga cgtgtacctc tgtgtgttca tggagctgga gaaaccaaaa ctgggtctct   1020

ctccacccgg gagctgagga ggggtggggg ccgtttgttc agttacctgg gggaacctca   1080

cccagcaccc tgccccgctt cccagggctg gccaagagag aagactggac ggcagggagg   1140

tcaacattaa cgagtggggg gatcacaaag ccaggggctt ggccccaccc cagcgaagcc   1200

atgaactccc aagccccggc ctcagcctaa ccaggaaagg ggctcggagg gagaaaggcc   1260

cagggcagtg gggacgggtc ccagcacctc ggagccccct tcacacgccc cctaccggcc   1320

catgtttcta tttgcatttc cccctcctca gatgggaagc ctggcaaagc tgcccaaccg   1380

ggtagtgccc ctcacccatc ggatcactgc cttcttcctc ctcttgcccc attcacccgc   1440

ttccttgcac tctgggagtg gggcagggta aggtgggcct tacagacagg ctgaggtttg   1500

ggtggtgtga tctgtcctaa ttggcccctc accaatgcat ctatctgtct gccaccagcc   1560

caccccaccc tgcccccacc ctcacccacg cttctgctca ttggtctcaa tcccagcctg   1620

gaagcaggga gtaaggctgg actccaatgg cccattcccc tcaccccagc ccaagacgtg   1680

ggaggctgct tcccagtaag aatccaggag caagctttgg tgaatccagt gggctgagtg   1740

gctctatgga tgtggttgtt tggatgtggt agggagtgct tagcagaatg tgtgtgtatc   1800

tctgaggctg tcagggggtg ggtgggtgtg tgtctctgtt ggacctgtct ctcctcagtc   1860

tattcctgtc atagatgtgg gtgtccctgg tagggaagtg cctgtgtggt ctgtttacag   1920

tgcagaaggc ggctcagcag tgcaatgggc tgacagcctt ggaccgggag tcagaagcct   1980

gggttctggt tgtagctctg gcccctccct gtgatcttca acaagccact tgctttctct   2040

cgtcttcagt ttcctcaact agaaaatgaa cagcagctga aattatgttg aagatccttt   2100

tatacctgaa agagtttctt catagaaatt tctgtggtgg ggagggggca atctctgtgt   2160

gtctcagtat acctaaaggt tggggtgggg cggagttgtg tgtctctgta gaaaggcgaa   2220

ggggcagttc ctatcaggac tgtgtatgtc tgagcacatg tggctctgtt tgggattacg   2280

tgtttgtctg tgaatgtgtg tgtgtgttgg agggttgtct attgtgtgtg gctgtatagg   2340

gtgtctgtag atcaagatgt gtatacagct gcttctgcta ttgctggttt gggggagggg   2400

actggaaagc tgagactgaa aatcaagagg gaagaggtga ggaaggccca cccctggggc   2460

tgggcagtgt agacctgcca ccgtgtgaag aaaaatgaaa gcacagatag cctaagactg   2520

cacaggcctg tgcccacata ccttatagca caggcccagg tggatcatct catgctaaca   2580

ccccacatgt gctggtggat ccactcccat ggatccactc acatgctgca ggcatgcagt   2640

agactcaccc acagcccact ctctggacac caatcctggg aggtgggagc tggaatgggg   2700

agcaatgaga ggagggagtg agactgttgg cttaggaagg gtggtacctc tccctgcatc   2760

atacccagga actgccagct ccaaaatatt ggggtacagc tcaccacccc ccactccgcc   2820

aacccattcc tacctcctct agtgcaggga cccaagttag atgatgagaa aatgccaaac   2880

aaagggaggc aaggacagag aaggtacctg caggacccac aaggcccata ctggccccca   2940

tctgaaccca cctctcccac ccagatcaac atccccccaa cccctgtgcc cccatcatct   3000

ggaccccaga gccagccctc ccactaccac caccaccacc ccggggctcc ttggctcacc   3060

tttctagaac atgggtacct cctctttttg ggggctcatt tagactgctg cctttgctgc   3120

tgacttgcag tgtgactcgg gcccattgtt caatctctgt ggccctgaga caccagggaa   3180

aatctccccc cccacaggac atactagttc cctggcaggc aagggcttcc aactgaggca   3240

gtgcatgtgt ggcagagaga ggcaggaagc tggcagtggc agcttctgtg tctagggagg   3300

ggtgtggctc cctccttccc tgtctgggag gttggaggga agaatctagg ccttagcttg   3360

ccctcctgcc acccttcccc ttgtagatac tgccttaaca ctccctcctc tctcagctgt   3420

ggctgccacc cagccaggtt tctccgtgct cactaattta tttccaggaa ggtgtgtgga   3480

agacatgagc cgtgtataat atttttttta acattttcat tgcagtattg accatcatcc   3540

ttggttgtgt atcgtgtaac acaaataatg atattaaaag catcaaacaa gccaaaaaaa   3600

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                       3641


<210>  615
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  615

Met Met Glu Glu Ile Asp Arg Phe Gln Val Pro Thr Ala His Ser Glu 
1               5                   10                  15


Met Gln Pro Leu Asp Pro Ala Ala Ala Ser Ile Ser Asp Gly Asp Cys 
            20                  25                  30


Asp Ala Arg Glu Glu Lys Gln Arg Glu Leu Ala Arg Lys Gly Ser Leu 
        35                  40                  45


Lys Asn Gly Ser Met Gly Ser Pro Val Asn Gln Gln Pro Lys Lys Asn 
    50                  55                  60


Asn Val Met Ala Arg Thr Arg Leu Val Val Pro Asn Lys Gly Tyr Ser 
65                  70                  75                  80


Ser Leu Asp Gln Ser Pro Asp Glu Lys Pro Leu Val Ala Leu Asp Thr 
                85                  90                  95


Asp Ser Asp Asp Asp Phe Asp Met Ser Arg Tyr Ser Ser Ser Gly Tyr 
            100                 105                 110


Ser Ser Ala Glu Gln Ile Asn Gln Asp Leu Asn Ile Gln Leu Leu Lys 
        115                 120                 125


Asp Gly Tyr Arg Leu Asp Glu Ile Pro Asp Asp Glu Asp Leu Asp Leu 
    130                 135                 140


Ile Pro Pro Lys Ser Val Asn Pro Thr Cys Met Cys Cys Gln Ala Thr 
145                 150                 155                 160


Ser Ser Thr Ala Cys His Ile Gln 
                165


<210>  616
<211>  2664
<212>  DNA
<213>  Homo sapiens

<400>  616
agaaattcag gagacacaga caagttcttc cacgatgtcg tacagacgag aactagagaa     60

ataccgtgac ctggatgaag atgaaatcct tggagcccta acagaggaag agctgaggac    120

cctggaaaat gagctggatg agctggaccc tgataatgca ctgctgcctg caggcctgag    180

gcagaaggat cagaccacca aggcgcccac gggccccttt aaaagagagg agctcttgga    240

tcacttggaa aagcaagcaa aggagtttaa ggaccgagaa gatctggtcc cctacacagg    300

ggaaaaacga ggaaaggtct gggttcctaa gcagaagcca ctggatcctg tgctggaaag    360

tgtgacgctg gaaccggagc tggaggaagc cttggcaaat gcttcagatg cagaactctg    420

tgacattgca gcgatcctgg gcatgcacac gctcatgagt aaccagcagt actaccaggc    480

cctgagcagc agctccatca tgaacaagga ggggctcaac agcgtgatta aacccacaca    540

atacaagcct gtgcccgacg aagaaccaaa ttcaacagac gtagaggaaa cgctggaacg    600

gataaagaac aacgacccaa aacttgaaga agttaacctc aataatatcc ggaatatccc    660

catccccacc ctcaaggcat atgcagaagc cctgaaagaa aactcatatg tgaagaagtt    720

cagcatcgtg gggacacgga gtaatgaccc cgtggcgtat gcccttgctg agatgctcaa    780

ggagaacaag gtgttgaaga cactgaatgt ggaatccaac ttcatttctg gagctgggat    840

tctgcgcctg gtagaagccc tcccatacaa cacttctctg gtggaaatga aaattgacaa    900

ccagagccag cccctgggca acaaagtgga aatggagatt gtgagcatgt tggaaaaaaa    960

cgcaacactt ctcaaattcg gctaccactt tacccagcaa ggaccccggc ttcgggcatc   1020

caacgcaatg atgaacaaca atgaccttgt gaggaagagg aggcttgcgg acctgactgg   1080

gcccatcatt cccaagtgcc ggagtggtgt ctagtgtgtg gcggtggagt ccatgccttt   1140

gaactggatg tgttctattg atgacctgtg ctctgcaggg gaaaccagaa ggcaaaatgc   1200

tggcagcatg aaaccctttt gtggttcagt tctttatgca ctaaggtttt aggttgacta   1260

gtggttgtag ttgaaaattt tataaaatac cgttaatgtg aagtttttct ttagtcacag   1320

aagttgaatc tggttattat ttaaaaacta gaagccccca aaccagcaga tcttactgaa   1380

gatgatgttc cagcagcagc gacttagccc caggagccca gtttcaatgg ccttgctgtg   1440

tggtgtttca agtgcattta aaatgtgtga cacagaaacg gcacactctt ccacatgctt   1500

ttgaagtatt ataaaacact ttattacaaa tttgtcttag ctattagcaa ataaaactga   1560

ttatcattct ttattaaccc tccttggaat tttgaaaacc tcgattaaag ttgccaaatt   1620

gattactgga tccagaacac aattttcccc tcagaacaga tagacagact gaagccactg   1680

aactctgcca ggagtcaaca tgagattcct tttgctggat atgcagaaat gataggaaaa   1740

aaaccaatgg tgaaatttca agtttcaaaa accaaccttt cattaccaat cccaggcaac   1800

aaacatgtcc ctgagtgttc tttaagaaca tttgggattt atgtacaatt taatactgga   1860

gttagaactt tttccttatt gaatgccaac cttatgatgg atgtgaaaat ctacggccaa   1920

atacttttga aaacaccttt ctatattgca cagtgggcaa atggcttatg tgaggtaaga   1980

cactagaggg ataaatttcc agatcaacat ggctatggta tttagtaatg gcccagctta   2040

gagacttcag ctactgatct catcacttat tagacaaatt gctgctgacc ttacgcctgt   2100

atattaagcc tccgcaggat gccggacaat ggtgaagaaa ctccagatat caaggaattg   2160

ggaaatcctg gccaaaccac cccaagatga ttacactgaa atgtagtatt agtactgctg   2220

ccagatctct ttttaacatc atgtgcgtct cttgggatcc agcaaaagtg ttaagccaca   2280

atgcccttgt gccttttaat ataccacagt gccagttaaa ctaatatttt tgtttgttgc   2340

ttttgggagt tattttcatt agtgatttca gcaaatctca tgataaagga caaggtcaag   2400

aactccagag cactgagcag agaggctggt gatgaaaagg tgaaggcctg cgcactgaac   2460

tgtaaggcag tgggcagtac agggtaactg gaggcggggc cagggcctca gcgctatgga   2520

agagtgtcca ctgaggctgc acatggccca ggagtggcac catgttgcag ggacaaccat   2580

ccccatttgg cttctcctta aaacacaatt gcagctgcat tctgcatcgc tgaaaactgc   2640

aatataatat taaatctgtt ggtc                                          2664


<210>  617
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  617

Met Ser Tyr Arg Arg Glu Leu Glu Lys Tyr Arg Asp Leu Asp Glu Asp 
1               5                   10                  15


Glu Ile Leu Gly Ala Leu Thr Glu Glu Glu Leu Arg Thr Leu Glu Asn 
            20                  25                  30


Glu Leu Asp Glu Leu Asp Pro Asp Asn Ala Leu Leu Pro Ala Gly Leu 
        35                  40                  45


Arg Gln Lys Asp Gln Thr Thr Lys Ala Pro Thr Gly Pro Phe Lys Arg 
    50                  55                  60


Glu Glu Leu Leu Asp His Leu Glu Lys Gln Ala Lys Glu Phe Lys Asp 
65                  70                  75                  80


Arg Glu Asp Leu Val Pro Tyr Thr Gly Glu Lys Arg Gly Lys Val Trp 
                85                  90                  95


Val Pro Lys Gln Lys Pro Leu Asp Pro Val Leu Glu Ser Val Thr Leu 
            100                 105                 110


Glu Pro Glu Leu Glu Glu Ala Leu Ala Asn Ala Ser Asp Ala Glu Leu 
        115                 120                 125


Cys Asp Ile Ala Ala Ile Leu Gly Met His Thr Leu Met Ser Asn Gln 
    130                 135                 140


Gln Tyr Tyr Gln Ala Leu Ser Ser Ser Ser Ile Met Asn Lys Glu Gly 
145                 150                 155                 160


Leu Asn Ser Val Ile Lys Pro Thr Gln Tyr Lys Pro Val Pro Asp Glu 
                165                 170                 175


Glu Pro Asn Ser Thr Asp Val Glu Glu Thr Leu Glu Arg Ile Lys Asn 
            180                 185                 190


Asn Asp Pro Lys Leu Glu Glu Val Asn Leu Asn Asn Ile Arg Asn Ile 
        195                 200                 205


Pro Ile Pro Thr Leu Lys Ala Tyr Ala Glu Ala Leu Lys Glu Asn Ser 
    210                 215                 220


Tyr Val Lys Lys Phe Ser Ile Val Gly Thr Arg Ser Asn Asp Pro Val 
225                 230                 235                 240


Ala Tyr Ala Leu Ala Glu Met Leu Lys Glu Asn Lys Val Leu Lys Thr 
                245                 250                 255


Leu Asn Val Glu Ser Asn Phe Ile Ser Gly Ala Gly Ile Leu Arg Leu 
            260                 265                 270


Val Glu Ala Leu Pro Tyr Asn Thr Ser Leu Val Glu Met Lys Ile Asp 
        275                 280                 285


Asn Gln Ser Gln Pro Leu Gly Asn Lys Val Glu Met Glu Ile Val Ser 
    290                 295                 300


Met Leu Glu Lys Asn Ala Thr Leu Leu Lys Phe Gly Tyr His Phe Thr 
305                 310                 315                 320


Gln Gln Gly Pro Arg Leu Arg Ala Ser Asn Ala Met Met Asn Asn Asn 
                325                 330                 335


Asp Leu Val Arg Lys Arg Arg Leu Ala Asp Leu Thr Gly Pro Ile Ile 
            340                 345                 350


Pro Lys Cys Arg Ser Gly Val 
        355


<210>  618
<211>  4445
<212>  DNA
<213>  Homo sapiens

<400>  618
agtgggctac gaacgtctgg cacacatgca accgccccct cgggctgcct ccgcctgccg     60

gctacttctt tctcccgcct tccgctctat gtccttccgg ggccacgcag aaagtgccgc    120

cgctttggcc actcagagcc cccgggccgc ggtcgtcgta cgcctgaagg cgggtcgtgc    180

cggcggccgc tctagtctcc gcctccgctc aggccggtcc tccggggctt ctcaatggtt    240

tcccggtggc ctctcaatgg ttttcccggc ggcccttgcg ccgacgccag gagacttccg    300

gagcttggtg acgtcacgag cgagcttttc tacccaaata cgcggcgggg gaataggctc    360

gagggcggtg agcagtgaca attgctaggc ggagacagtg cagggaagag agaccttaga    420

aaggatcagg actggcggga ggtatttaac tgaaaggaat atctgcttca ctgttgcaac    480

caaaccagat gccttcttcc acttcaccag accaaggaga tgacctggag aactgcattt    540

taagattttc tgacctggat ttaaaagata tgagtcttat taatcccagc agcagtctta    600

aagcagaatt agatggcagt acaaaaaaga aatactcgtt tgcaaagaaa aaggcctttg    660

ccctttttgt caaaaccaaa gaagttccaa caaaaaggag ttttgaatgt aaagaaaaat    720

tgtggaaatg ctgtcggcag ctattcacag accaaaccag catccataga catgtggcaa    780

cacaacatgc tgatgaaatt tatcaccaga cagcttctat tttaaagcaa ctggctgtga    840

cattgagcac ctcaaagagt ctttcgtctg cagatgaaaa gaacccttta aaagagtgcc    900

ttccacatag ccatgacgtg tctgcttggc tccctgatat aagctgcttt aaccctgatg    960

agctgataag tggccagggc agtgaagaag gggaggtgct cctttattac tgctaccatg   1020

acctggagga tccccaatgg atctgtgcct ggcagacagc tctgtgtcag cacctgcacc   1080

tcacaggcaa gattcgaatt gctgcagaag gaatcaatgg gacagttggt ggaagcaaat   1140

tggctaccag actttatgtg gaagtcatgc tttccttccc attgtttaag gatgacctgt   1200

gtaaagatga ttttaagacc agcaaaggag gagctcactg ttttccagaa ttgcgtgttg   1260

gtgtatttga agaaatcgtg cccatgggga tcagccccaa aaagatctcc tacaagaagc   1320

ctggaatcca tttatcccca ggtgaatttc ataaagaagt agaaaagttt ttatctcagg   1380

caaatcaaga acaaagtgat actatccttc ttgattgcag aaacttctat gaaagcaaaa   1440

taggacgatt ccaaggctgc ttagccccag acatcaggaa attcagttac ttccctagct   1500

acgttgacaa aaatctagaa cttttcagag agaagagagt gctgatgtac tgtaccgggg   1560

gcatccgctg tgagcggggt tcagcctacc tcaaagccaa gggagtgtgc aaggaggtgt   1620

tccagctcaa gggtggcatc cacaagtacc tggaagagtt tcctgatggc ttttacaaag   1680

ggaagttgtt tgtttttgat gaacgctatg ctctgtccta caacagtgat gtggtgtcag   1740

agtgttcata ctgtggagcc cgctgggacc agtataaact ctgctctact ccccagtgcc   1800

gccagctcgt tttgacctgc cctgcctgtc aaggacaagg attcacagcc tgttgtgtca   1860

catgtcaaga caaggggagc aggaaagttt caggccctat gcaagacagc tttaaagagg   1920

aatgcgagtg cacagcccga cggccacgca tacctaggga actcttgcag catgtgcgac   1980

agcctgtgag cccagagcca gggcctgatg ctgatgagga tgggccagtg cttatgtgag   2040

cagcaccttt ggcattttcc caggccctcg gtaaaagtag gtttggggtg actatacaga   2100

gaaagcatgg caagactgca gaaacagaga aatcgggaac ttcagttctg gccgctgcca   2160

ccgtggcagc cgtctacact tcacagcggg aggggaggag tcacgttgtc taccacttac   2220

ctgagacatt ctgatttgga tgatgctaga gcacagaaaa taggtgagct gcatgggatc   2280

ccaaagctgc tgagggatag agcctgagcc tggtggccac agcatatgcc ctttctgttc   2340

catgcagctg gggctgttag tagtcattgc ccttgtcagc agaccttcta ccctggtggc   2400

aaacacatga aagctgtggc cctgggagtg gcctcctaaa acaagccact taggtcatct   2460

gccatctacc cttaacctct gtctctcgcc tgaggggaat ctgcaagctg tgcattgggc   2520

ttacctcctg cttttgtaga aataaccatc ctttggtata catggaggat agttccagaa   2580

cgcctgagta tacaaaaacc caatgcatac tcaagtccca cagtgggccc tacagaaccc   2640

acgtatgtga taaatcagcc ctccatgtac gcaggtttcg ccccctgcca atactgtatt   2700

ttcaacctgt atggttgaaa aaaatccata tataagtgca gccatgcagt tcaaacccat   2760

attgttcaag ggtcaactgt atagtttatt gaacagccac acccattcct ttacacatga   2820

tctatggcag agttgaatag ttgcaacaga cactatgtgg cctgcaaaat cggaaatttt   2880

tactgtctgg ccttttacag aaaagtttgc cagcccctga tctagaccag cagctcatct   2940

gatagaggca gaggtggcct taaagatgtg gccttcttca ttttctgttg gtttggtttc   3000

gtttctatga gagatttcct ctgatagctc tgctttcccc agcacttact ctctgagctt   3060

ttaaatgttc tctctgggag cttcatataa gctcggtgac atttgagcca cagtttttag   3120

atcagcacct ggaatacatg acacattctt actgaggtca tccagcactg ccatggtggc   3180

tgcccagtct tctggccagt gtgccaggca catgtccctg tcacacaggt tccaagaaac   3240

acatacgcag ccatgcatag accaacagat ttaatattat attgcagttt tcagcgatgc   3300

agaatgcagc tgcaattgtg ttttaaggag aagccaaatg gggatggttg tccctgcaac   3360

atggtgccac tcctgggcca tgtgcagcct cagtggacac tcttccatag cgctgaggcc   3420

ctggccccgc ctccagttac cctgtactgc ccactgcctt acagttcagt gcgcaggcct   3480

tcaccttttc atcaccagcc tctctgctca gtgctctgga gttcttgacc ttgtccttta   3540

tcatgagatt tgctgaaatc actaatgaaa ataactccca aaagcaacaa acaaaaatat   3600

tagtttaact ggcactgtgg tatattaaaa ggcacaaggg cattgtggct taacactttt   3660

gctggatccc aagagacgca catgatgtta aaaagagatc tggcagcagt actaatacta   3720

catttcagtg taatcatctt ggggtggttt ggccaggatt tcccaattcc ttgatatctg   3780

gagtttcttc accattgtcc ggcatcctgc ggaggcttaa tatacaggcg taaggtcagc   3840

agcaatttgt ctaataagtg atgagatcag tagctgaagt ctctaagctg ggccattact   3900

aaataccata gccatgttga tctggaaatt tatccctcta gtgtcttacc tcacataagc   3960

catttgccca ctgtgcaata tagaaaggtg ttttcaaaag tatttggccg tagattttca   4020

catccatcat aaggttggca ttcaataagg aaaaagttct aactccagta ttaaattgta   4080

cataaatccc aaatgttctt aaagaacact cagggacatg tttgttgcct gggattggta   4140

atgaaaggtt ggtttttgaa acttgaaatt tcaccattgg tttttttcct atcatttctg   4200

catatccagc aaaaggaatc tcatgttgac tcctggcaga gttcagtggc ttcagtctgt   4260

ctatctgttc tgaggggaaa attgtgttct ggatccagta atcaatttgg caactttaat   4320

cgaggttttc aaaattccaa ggagggttaa taaagaatga taatcagttt tatttgctaa   4380

tagctaagac aaatttgtaa taaagtgttt tataatactt caaaagcaaa aaaaaaaaaa   4440

aaaaa                                                               4445


<210>  619
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  619

Met Pro Ser Ser Thr Ser Pro Asp Gln Gly Asp Asp Leu Glu Asn Cys 
1               5                   10                  15


Ile Leu Arg Phe Ser Asp Leu Asp Leu Lys Asp Met Ser Leu Ile Asn 
            20                  25                  30


Pro Ser Ser Ser Leu Lys Ala Glu Leu Asp Gly Ser Thr Lys Lys Lys 
        35                  40                  45


Tyr Ser Phe Ala Lys Lys Lys Ala Phe Ala Leu Phe Val Lys Thr Lys 
    50                  55                  60


Glu Val Pro Thr Lys Arg Ser Phe Glu Cys Lys Glu Lys Leu Trp Lys 
65                  70                  75                  80


Cys Cys Arg Gln Leu Phe Thr Asp Gln Thr Ser Ile His Arg His Val 
                85                  90                  95


Ala Thr Gln His Ala Asp Glu Ile Tyr His Gln Thr Ala Ser Ile Leu 
            100                 105                 110


Lys Gln Leu Ala Val Thr Leu Ser Thr Ser Lys Ser Leu Ser Ser Ala 
        115                 120                 125


Asp Glu Lys Asn Pro Leu Lys Glu Cys Leu Pro His Ser His Asp Val 
    130                 135                 140


Ser Ala Trp Leu Pro Asp Ile Ser Cys Phe Asn Pro Asp Glu Leu Ile 
145                 150                 155                 160


Ser Gly Gln Gly Ser Glu Glu Gly Glu Val Leu Leu Tyr Tyr Cys Tyr 
                165                 170                 175


His Asp Leu Glu Asp Pro Gln Trp Ile Cys Ala Trp Gln Thr Ala Leu 
            180                 185                 190


Cys Gln His Leu His Leu Thr Gly Lys Ile Arg Ile Ala Ala Glu Gly 
        195                 200                 205


Ile Asn Gly Thr Val Gly Gly Ser Lys Leu Ala Thr Arg Leu Tyr Val 
    210                 215                 220


Glu Val Met Leu Ser Phe Pro Leu Phe Lys Asp Asp Leu Cys Lys Asp 
225                 230                 235                 240


Asp Phe Lys Thr Ser Lys Gly Gly Ala His Cys Phe Pro Glu Leu Arg 
                245                 250                 255


Val Gly Val Phe Glu Glu Ile Val Pro Met Gly Ile Ser Pro Lys Lys 
            260                 265                 270


Ile Ser Tyr Lys Lys Pro Gly Ile His Leu Ser Pro Gly Glu Phe His 
        275                 280                 285


Lys Glu Val Glu Lys Phe Leu Ser Gln Ala Asn Gln Glu Gln Ser Asp 
    290                 295                 300


Thr Ile Leu Leu Asp Cys Arg Asn Phe Tyr Glu Ser Lys Ile Gly Arg 
305                 310                 315                 320


Phe Gln Gly Cys Leu Ala Pro Asp Ile Arg Lys Phe Ser Tyr Phe Pro 
                325                 330                 335


Ser Tyr Val Asp Lys Asn Leu Glu Leu Phe Arg Glu Lys Arg Val Leu 
            340                 345                 350


Met Tyr Cys Thr Gly Gly Ile Arg Cys Glu Arg Gly Ser Ala Tyr Leu 
        355                 360                 365


Lys Ala Lys Gly Val Cys Lys Glu Val Phe Gln Leu Lys Gly Gly Ile 
    370                 375                 380


His Lys Tyr Leu Glu Glu Phe Pro Asp Gly Phe Tyr Lys Gly Lys Leu 
385                 390                 395                 400


Phe Val Phe Asp Glu Arg Tyr Ala Leu Ser Tyr Asn Ser Asp Val Val 
                405                 410                 415


Ser Glu Cys Ser Tyr Cys Gly Ala Arg Trp Asp Gln Tyr Lys Leu Cys 
            420                 425                 430


Ser Thr Pro Gln Cys Arg Gln Leu Val Leu Thr Cys Pro Ala Cys Gln 
        435                 440                 445


Gly Gln Gly Phe Thr Ala Cys Cys Val Thr Cys Gln Asp Lys Gly Ser 
    450                 455                 460


Arg Lys Val Ser Gly Pro Met Gln Asp Ser Phe Lys Glu Glu Cys Glu 
465                 470                 475                 480


Cys Thr Ala Arg Arg Pro Arg Ile Pro Arg Glu Leu Leu Gln His Val 
                485                 490                 495


Arg Gln Pro Val Ser Pro Glu Pro Gly Pro Asp Ala Asp Glu Asp Gly 
            500                 505                 510


Pro Val Leu Met 
        515


<210>  620
<211>  5381
<212>  DNA
<213>  Homo sapiens

<400>  620
attgagaggc caccgggaaa ccattgagaa gccccggagg accggcctga gcggaggcgg     60

agactagagc ggccgccggc acgacccgcc ttcaggcgta cgacgaccgc ggcccggggg    120

ctctgagtgg ccaaagcggc ggcactttct gcgtggcccc ggaaggacat agagcggaag    180

gcgggagaaa gaagtagccg gcaggcggag gcagcccgag ggggcggttg catgtgtgcc    240

agacgttcgt agcccactga gcttcctcac gccggctgtc gcagcgccta gccccacccg    300

gcggcctctc ctgcgcttcc ggggccgtgg cgagctagtg cgcctgcgtg ccggcccatc    360

cgcgcgcctt gcagctgtcc ttgcgtcggc cagcggccag acagttcctg cagcgcttac    420

cgcctggcct ctcggttccg cggcgcaccg gagggcagca tgtcgcggcg gcggcacagc    480

gacgagaacg acggtgggca gcctcacaaa aggagaaaga cctctgatgc aaatgaaact    540

gaagatcatt tggaatcttt aatatgtaaa gtaggagaaa agagtgcctg ctctttggag    600

agcaacctag aaggcttggc tggtgttttg gaagctgatc ttcctaacta caagagcaag    660

atcttaaggc ttctttgtac agttgcacgc ctattacctg agaagctgac aatttataca    720

acattagttg gactactgaa tgccaggaat tacaattttg gtggagaatt tgtagaagcc    780

atgattcgtc aacttaaaga atcattgaaa gcaaacaatt ataatgaagc cgtgtatttg    840

gtccgttttt tatctgatct tgtgaattgt catgtgattg ccgccccatc aatggttgct    900

atgtttgaaa attttgtaag cgtaactcag gaagaagatg tacctcaggt gcgacgagat    960

tggtatgtgt atgcatttct gtcatctttg ccctgggttg gaaaggagtt gtacgaaaag   1020

aaagatgcag agatggaccg catctttgcc aacactgaaa gctatcttaa aagacgccaa   1080

aagactcatg tacccatgtt acaggtatgg actgctgata aaccacatcc acaagaagag   1140

tatttagatt gcctgtgggc ccagattcag aaattgaaaa aggatcgctg gcaggaacgg   1200

cacatcctaa gaccttatct tgcctttgac agcatcctgt gtgaagcact gcagcacaat   1260

ctgcctcctt ttacaccacc tcctcacact gaagattcag tgtacccaat gccaagggtc   1320

atcttcagaa tgtttgatta cacagatgat cccgagggtc ctgtcatgcc agggagtcat   1380

tcagtggaaa gatttgtaat agaagagaat cttcactgca tcattaagtc ccactggaag   1440

gaaaggaaga cttgtgctgc acagttagtg agctatccag ggaagaacaa gatccccttg   1500

aactaccaca tagttgaggt gatctttgca gagctgtttc aacttccagc accccctcac   1560

attgatgtga tgtacacaac actcctcatt gaactgtgca aacttcaacc tggctctcta   1620

ccccaagttc ttgcacaggc aactgaaatg ctatacatgc gtttggacac aatgaacact   1680

acctgtgtag acaggtttat taattggttt tctcatcatc taagtaactt ccagttccgt   1740

tggagctggg aagattggtc agattgtctt agtcaagatc ctgaaagtcc caaaccgaag   1800

tttgtaagag aagttctaga aaaatgtatg aggttgtctt accatcagcg tatattagat   1860

attgttcctc ctaccttctc agctctgtgt cctgcaaacc caacctgcat ttacaagtat   1920

ggagatgaaa gtagcaattc tcttcctgga cattctgttg ccctctgttt agctgttgcc   1980

tttaaaagta aggcaaccaa tgatgaaatc ttcagcattc tgaaagatgt accaaatcct   2040

aaccaggatg atgacgacga tgaaggattc agttttaacc cattgaaaat agaagtcttt   2100

gtacagactc tgctacactt ggcagccaaa tcattcagcc actccttcag tgctcttgca   2160

aagtttcatg aagtcttcaa aaccctagct gaaagtgatg aaggaaagtt acatgtgcta   2220

agagttatgt ttgaggtctg gaggaaccat ccacagatga ttgctgtact agtggataag   2280

atgattcgta cacaaatagt tgattgtgct gccgtagcaa attggatctt ctcttcagaa   2340

ctatctcgtg actttaccag attgtttgtt tgggaaattt tgcactctac aattcgtaag   2400

atgaacaaac atgtcctgaa gatccagaaa gagctggaag aagctaaaga gaaacttgct   2460

aggcaacaca aacggcgaag tgatgatgac gacagaagca gtgacaggaa agacggggtt   2520

cttgaggaac aaatagaacg acttcaggaa aaagtggaat ctgctcagag tgaacaaaag   2580

aatcttttcc tcgttatatt tcagcggttt atcatgatct tgaccgagca cctagtacga   2640

tgcgaaactg atgggaccag tgtattaaca ccatggtata agaactgtat agagaggctg   2700

cagcagatct tcctacagca tcaccaaata atccagcagt acatggtgac cctggagaac   2760

cttctcttca ctgctgaatt agaccctcat atcttggccg tgttccagca gttctgtgcc   2820

ctgcaggcct aagggtcatt ttttcctcat gtcaaggttt tttttgatat cttaaaataa   2880

tttgtcttat tttttgatgg tttgaatgct tgctttcttg tagtatcctt tcacttctta   2940

aaggaaacaa aggggaagag gacagtgaat gaacatggca ttacttttaa ttgccctgaa   3000

aagcaaatac ttcctaacgg cagtaatgtg actatgacca tgatatatta tatatgtgac   3060

agatacaaat tctctgtgat cagtttgtta ttttttttct ccttaaggca caaaataatt   3120

ggtttgaggt atgtgaaaca ctagaggtca accttacata gtatatagaa ctgatgggtt   3180

tacccagcta cccagtagca taacttttca cagctcgggg atgaattaac atggctgaaa   3240

taaaactaaa agtatggttt ttaaactttg gcatttcatg atttatcatc tcactctact   3300

ctaaaactgg tggtttctta ctgaaggtgt tctccatttg aaattttatc ttcaaagtat   3360

ttttaagtag tatctttaag acatgacttg ttagtaataa aagtgttact agttggaaga   3420

gtagctctca aatttgtctt aatgtaaatc acctgggaat ctttcaagtt attttgaaat   3480

ttaaaccacc gtctgggggt ggaacgcaga catcctcagt aatccttaaa gtttccccag   3540

gtgattccag gtttggtcac cattatctta gagcatctac tcacttcctc tagccttggg   3600

gttatttgtc caaggtcttg tagtgagtta cagaatacta aagtggatgt agaagtggtc   3660

agattgactg aaactatacc ctgaattaga tgtgagttta gattttgttt atatggaacc   3720

tgatccaaaa aactacgaag tcctgagctt gtttcctgta tagtactgat gctgaaataa   3780

gatgacagca gtttgtaaaa taatacacaa atatgaggaa ttgtctgaca ttccaaattt   3840

cgaggatttt tagacttttt tcattaaacc ttagaaaaaa attaccagta atcctacaac   3900

tactggtagt gttgttgtgc atttgcacaa aataggtata attttttctt attacatccc   3960

aagtttatga tgcattaagc gttttgcata ttttgatata tttttgcttt ggtttaccat   4020

acattttagt ggctacagaa tgtagtctgc ttaataaatg ggaattccta gaatgtttaa   4080

ataccatact atttaagaca aaatacaaaa tatccagaaa aatccaggtt gcgtggctgg   4140

ttagtaaagg actaaaaccc aggttcttgg ctaaatgttt tcgtttatac tgtttatctt   4200

tcccattgct taagcacagc acaaactatg taattatata taattacagt tgacccttga   4260

acaacatggg tttgaactgt gtgagtctcc ttacacacag gttttcttcc acccctgaga   4320

tggcaagacc agccccttgt cttcctcagc ctgctcaacg tgaagatgat gaggatgaag   4380

acctttatga tgatccactt ctacttatta aatagtaaat atattttttt cttatgattt   4440

tattttcttt tctctagctt cataagaata tagcatatgg gctgggcgca gtggctcacg   4500

cctgtaatcc cagcactttg ggaggctgag gcgggcggat cacaaggtca ggagattgag   4560

accatcctgg ctaacacagt gaaaccctgt ctctactaaa aacacaaaaa cttagccagg   4620

cgtggtggta catggctgta gtcccagcta cttgggaggc tgagacagga gaatcgcttg   4680

aacctgggag gtggaggttt cagtgagcca agattgtgcc actgcactcc agcctgggtg   4740

atggagcgag gctctgtctc aaaaaagaaa aaaaatatat agcatataac atacaaaatg   4800

agtttatcaa ctgtttgtta ttggtaagtc agcagtgggc tattggtggt taagttttgg   4860

gggagtcaaa agttacatgc aaatttttta ctgtgcgggg tgtcagcatc cctaacccca   4920

tgttgttcaa gggtcaactg tagtttaaaa tgactcctgt ctcaaaaaac caaaggataa   4980

cctttaaggg attggtaact ttgactcaaa actgctttgt aatcttttca caatgtactg   5040

aaaagtgtgg ctagttatgt ttgatccaca ttctagagaa atttgtaggt tttaatttct   5100

tttctcttgg tcctctcttc atgtataatg gttgctttta acagctgttc gctgatgtgg   5160

tcctgctctg tcccagtcta gcagctttag tgtatggaaa aattgaacta ggaattgagt   5220

tttgaagaaa taaaggtgta agagcaaaca ttcaacagtt gctgtcccca gtaatgaagt   5280

tcatacagac aaaagatggc atgtcactgt acatcatacc ttgcaataaa tattctgtta   5340

aattgtgctg gtgcaattta acatgctttt gtcaaagtaa a                       5381


<210>  621
<211>  790
<212>  PRT
<213>  Homo sapiens

<400>  621

Met Ser Arg Arg Arg His Ser Asp Glu Asn Asp Gly Gly Gln Pro His 
1               5                   10                  15


Lys Arg Arg Lys Thr Ser Asp Ala Asn Glu Thr Glu Asp His Leu Glu 
            20                  25                  30


Ser Leu Ile Cys Lys Val Gly Glu Lys Ser Ala Cys Ser Leu Glu Ser 
        35                  40                  45


Asn Leu Glu Gly Leu Ala Gly Val Leu Glu Ala Asp Leu Pro Asn Tyr 
    50                  55                  60


Lys Ser Lys Ile Leu Arg Leu Leu Cys Thr Val Ala Arg Leu Leu Pro 
65                  70                  75                  80


Glu Lys Leu Thr Ile Tyr Thr Thr Leu Val Gly Leu Leu Asn Ala Arg 
                85                  90                  95


Asn Tyr Asn Phe Gly Gly Glu Phe Val Glu Ala Met Ile Arg Gln Leu 
            100                 105                 110


Lys Glu Ser Leu Lys Ala Asn Asn Tyr Asn Glu Ala Val Tyr Leu Val 
        115                 120                 125


Arg Phe Leu Ser Asp Leu Val Asn Cys His Val Ile Ala Ala Pro Ser 
    130                 135                 140


Met Val Ala Met Phe Glu Asn Phe Val Ser Val Thr Gln Glu Glu Asp 
145                 150                 155                 160


Val Pro Gln Val Arg Arg Asp Trp Tyr Val Tyr Ala Phe Leu Ser Ser 
                165                 170                 175


Leu Pro Trp Val Gly Lys Glu Leu Tyr Glu Lys Lys Asp Ala Glu Met 
            180                 185                 190


Asp Arg Ile Phe Ala Asn Thr Glu Ser Tyr Leu Lys Arg Arg Gln Lys 
        195                 200                 205


Thr His Val Pro Met Leu Gln Val Trp Thr Ala Asp Lys Pro His Pro 
    210                 215                 220


Gln Glu Glu Tyr Leu Asp Cys Leu Trp Ala Gln Ile Gln Lys Leu Lys 
225                 230                 235                 240


Lys Asp Arg Trp Gln Glu Arg His Ile Leu Arg Pro Tyr Leu Ala Phe 
                245                 250                 255


Asp Ser Ile Leu Cys Glu Ala Leu Gln His Asn Leu Pro Pro Phe Thr 
            260                 265                 270


Pro Pro Pro His Thr Glu Asp Ser Val Tyr Pro Met Pro Arg Val Ile 
        275                 280                 285


Phe Arg Met Phe Asp Tyr Thr Asp Asp Pro Glu Gly Pro Val Met Pro 
    290                 295                 300


Gly Ser His Ser Val Glu Arg Phe Val Ile Glu Glu Asn Leu His Cys 
305                 310                 315                 320


Ile Ile Lys Ser His Trp Lys Glu Arg Lys Thr Cys Ala Ala Gln Leu 
                325                 330                 335


Val Ser Tyr Pro Gly Lys Asn Lys Ile Pro Leu Asn Tyr His Ile Val 
            340                 345                 350


Glu Val Ile Phe Ala Glu Leu Phe Gln Leu Pro Ala Pro Pro His Ile 
        355                 360                 365


Asp Val Met Tyr Thr Thr Leu Leu Ile Glu Leu Cys Lys Leu Gln Pro 
    370                 375                 380


Gly Ser Leu Pro Gln Val Leu Ala Gln Ala Thr Glu Met Leu Tyr Met 
385                 390                 395                 400


Arg Leu Asp Thr Met Asn Thr Thr Cys Val Asp Arg Phe Ile Asn Trp 
                405                 410                 415


Phe Ser His His Leu Ser Asn Phe Gln Phe Arg Trp Ser Trp Glu Asp 
            420                 425                 430


Trp Ser Asp Cys Leu Ser Gln Asp Pro Glu Ser Pro Lys Pro Lys Phe 
        435                 440                 445


Val Arg Glu Val Leu Glu Lys Cys Met Arg Leu Ser Tyr His Gln Arg 
    450                 455                 460


Ile Leu Asp Ile Val Pro Pro Thr Phe Ser Ala Leu Cys Pro Ala Asn 
465                 470                 475                 480


Pro Thr Cys Ile Tyr Lys Tyr Gly Asp Glu Ser Ser Asn Ser Leu Pro 
                485                 490                 495


Gly His Ser Val Ala Leu Cys Leu Ala Val Ala Phe Lys Ser Lys Ala 
            500                 505                 510


Thr Asn Asp Glu Ile Phe Ser Ile Leu Lys Asp Val Pro Asn Pro Asn 
        515                 520                 525


Gln Asp Asp Asp Asp Asp Glu Gly Phe Ser Phe Asn Pro Leu Lys Ile 
    530                 535                 540


Glu Val Phe Val Gln Thr Leu Leu His Leu Ala Ala Lys Ser Phe Ser 
545                 550                 555                 560


His Ser Phe Ser Ala Leu Ala Lys Phe His Glu Val Phe Lys Thr Leu 
                565                 570                 575


Ala Glu Ser Asp Glu Gly Lys Leu His Val Leu Arg Val Met Phe Glu 
            580                 585                 590


Val Trp Arg Asn His Pro Gln Met Ile Ala Val Leu Val Asp Lys Met 
        595                 600                 605


Ile Arg Thr Gln Ile Val Asp Cys Ala Ala Val Ala Asn Trp Ile Phe 
    610                 615                 620


Ser Ser Glu Leu Ser Arg Asp Phe Thr Arg Leu Phe Val Trp Glu Ile 
625                 630                 635                 640


Leu His Ser Thr Ile Arg Lys Met Asn Lys His Val Leu Lys Ile Gln 
                645                 650                 655


Lys Glu Leu Glu Glu Ala Lys Glu Lys Leu Ala Arg Gln His Lys Arg 
            660                 665                 670


Arg Ser Asp Asp Asp Asp Arg Ser Ser Asp Arg Lys Asp Gly Val Leu 
        675                 680                 685


Glu Glu Gln Ile Glu Arg Leu Gln Glu Lys Val Glu Ser Ala Gln Ser 
    690                 695                 700


Glu Gln Lys Asn Leu Phe Leu Val Ile Phe Gln Arg Phe Ile Met Ile 
705                 710                 715                 720


Leu Thr Glu His Leu Val Arg Cys Glu Thr Asp Gly Thr Ser Val Leu 
                725                 730                 735


Thr Pro Trp Tyr Lys Asn Cys Ile Glu Arg Leu Gln Gln Ile Phe Leu 
            740                 745                 750


Gln His His Gln Ile Ile Gln Gln Tyr Met Val Thr Leu Glu Asn Leu 
        755                 760                 765


Leu Phe Thr Ala Glu Leu Asp Pro His Ile Leu Ala Val Phe Gln Gln 
    770                 775                 780


Phe Cys Ala Leu Gln Ala 
785                 790


<210>  622
<211>  1491
<212>  DNA
<213>  Homo sapiens

<400>  622
cactcagaaa ggccgctggg tgcggggagc gcagaggcgg tgcagggcgg ctggctcgcc     60

tcggcgtgca gtgcgcgtgc gtggagctgg gagctaggtc ctcggagtgg gccagagatg    120

gcggcggccg acggggcttt gccggaggcg gcggctttag agcaacccgc ggagctgcct    180

gcctcggtgc gggcgagtat cgagcggaag cggcagcggg cactgatgct gcgccaggcc    240

cggctggctg cccggcccta ctcggcgacg gcggctgcgg ctactggagg catggctaat    300

gtaaaagcag ccccaaagat aattgacaca ggaggaggct tcattttaga agaggaagaa    360

gaagaagaac agaaaattgg aaaagttgtt catcaaccag gacctgttat ggaatttgat    420

tatgtaatat gcgaagaatg tgggaaagaa tttatggatt cttatcttat gaaccacttt    480

gatttgccaa cttgtgataa ctgcagagat gctgatgata aacacaagct tataaccaaa    540

acagaggcaa aacaagaata tcttctgaaa gactgtgatt tagaaaaaag agagccacct    600

cttaaattta ttgtgaagaa gaatccacat cattcacaat ggggtgatat gaaactctac    660

ttaaagttac agattgtgaa gaggtctctt gaagtttggg gtagtcaaga agcattagaa    720

gaagcaaagg aagtccgaca ggaaaaccga gaaaaaatga aacagaagaa atttgataaa    780

aaagtaaaag aattgcggcg agcagtaaga agcagcgtgt ggaaaaggga gacgattgtt    840

catcaacatg agtatggacc agaagaaaac ctagaagatg acatgtaccg taagacttgt    900

actatgtgtg gccatgaact gacatatgaa aaaatgtgat tttttagttc agtgacctgt    960

tttatagaat tttatattta aataaaggaa atttagattg gtccttttca aaattcaaaa   1020

aaaaaagcaa catcttcata gatgaatgaa acccttgtat aagtaatact tcagtaataa   1080

ttatgtatgt tatggcttaa aagcaagttt cagtgaaggt cacctggcct ggttgtgtgc   1140

acaatgtcat gtctgtgatt gccttcttac aacagagatg ggagctgagt gctagagtag   1200

gtgcagaagt ggtaggtcag ctacaaattt gaggacaaga taccaaggca aaccctagat   1260

tggggtagag ggaaaagggt tcaacaaagg ctgaactgga ttcttaacca agaaacaaat   1320

aatagcaatg gtggtgcacc actgtacccc aggttctagt catgtgtttt ttaggacgat   1380

ttctgtctcc acgatggtgg aaacagtggg gaactactgc tggaaaaagc cctaatagca   1440

gaaataaaca ttgagttgta cgagtctgaa aaaaaaaaaa aaaaaaaaaa a            1491


<210>  623
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  623

Met Ala Ala Ala Asp Gly Ala Leu Pro Glu Ala Ala Ala Leu Glu Gln 
1               5                   10                  15


Pro Ala Glu Leu Pro Ala Ser Val Arg Ala Ser Ile Glu Arg Lys Arg 
            20                  25                  30


Gln Arg Ala Leu Met Leu Arg Gln Ala Arg Leu Ala Ala Arg Pro Tyr 
        35                  40                  45


Ser Ala Thr Ala Ala Ala Ala Thr Gly Gly Met Ala Asn Val Lys Ala 
    50                  55                  60


Ala Pro Lys Ile Ile Asp Thr Gly Gly Gly Phe Ile Leu Glu Glu Glu 
65                  70                  75                  80


Glu Glu Glu Glu Gln Lys Ile Gly Lys Val Val His Gln Pro Gly Pro 
                85                  90                  95


Val Met Glu Phe Asp Tyr Val Ile Cys Glu Glu Cys Gly Lys Glu Phe 
            100                 105                 110


Met Asp Ser Tyr Leu Met Asn His Phe Asp Leu Pro Thr Cys Asp Asn 
        115                 120                 125


Cys Arg Asp Ala Asp Asp Lys His Lys Leu Ile Thr Lys Thr Glu Ala 
    130                 135                 140


Lys Gln Glu Tyr Leu Leu Lys Asp Cys Asp Leu Glu Lys Arg Glu Pro 
145                 150                 155                 160


Pro Leu Lys Phe Ile Val Lys Lys Asn Pro His His Ser Gln Trp Gly 
                165                 170                 175


Asp Met Lys Leu Tyr Leu Lys Leu Gln Ile Val Lys Arg Ser Leu Glu 
            180                 185                 190


Val Trp Gly Ser Gln Glu Ala Leu Glu Glu Ala Lys Glu Val Arg Gln 
        195                 200                 205


Glu Asn Arg Glu Lys Met Lys Gln Lys Lys Phe Asp Lys Lys Val Lys 
    210                 215                 220


Glu Leu Arg Arg Ala Val Arg Ser Ser Val Trp Lys Arg Glu Thr Ile 
225                 230                 235                 240


Val His Gln His Glu Tyr Gly Pro Glu Glu Asn Leu Glu Asp Asp Met 
                245                 250                 255


Tyr Arg Lys Thr Cys Thr Met Cys Gly His Glu Leu Thr Tyr Glu Lys 
            260                 265                 270


Met 



<210>  624
<211>  1367
<212>  DNA
<213>  Homo sapiens

<400>  624
atgagctact gccaggtaga cagtgggttt ggatctgggc caaatatcct gacttcccaa     60

aacataagct tcaccactcg ctccaccttc tccaccaact accggtccct gggttctgtc    120

caggcaccca gctacggtgt ccggctggtc agcagcatag ccagcgtctg tacaggcacg    180

ggggctctgg ttcccggatc tccatgtccc gctccaccag ctacctgagc agcatgggtt    240

ccgggggcct ggccgcgggg atggccaggg gtctggcagg aatgagaggc atccagaaca    300

agaaggagac cgtgcaaaac ctgaacaact gcctggcctc ctacctggac agaatgagga    360

gcctggaggc caagaactgg aagctggaga gtaaaatcca ggagcacctg tagaagaagg    420

gaccccaggt cagagatgag ccattacttc aagaccattg agggcctgag gactcagatc    480

ttcacaaata ctgtggacaa tgcctgcatt gttctgcaga ttgacaatgc tggtcttgct    540

gctgatgact ttagagtcaa gtatgagaca gagctggcca tgcgccagtc tgtggagagc    600

cacatccatg ggctccggag gtcactgatg acaccagtgt cactcggctg cagctggaga    660

cagagatcga agctctcaag gaggagctgc tcttcatgaa gaagaaccac gaagaggaag    720

taaaagtgtt gggcattaca aaaggcctac aagcctagat tgccagctct gggttgacca    780

tggaggtaga tgcccccagt ctcgggacct tgccaagatc atggcagaca tccggcccca    840

atatgatgag ctggctcgga agaactgaga ggagctggac aaatactggt ctcagcagat    900

tgaggagagc acctcagtgg tcaccacgca gtccaccgag gttggagctg ctgggatgat    960

gctcacggag ctgagatgta tagtccagtc cttgaagatc aacctggact ccatgagaaa   1020

tctgaaggcc agcttggaga acagcctgag ggaggtcgag gcccgctatg ccttgcagag   1080

ggagcagctc aacgggatcc tgctgcacct ggagtcagag ctggcacaga cccgggcaga   1140

gggacagtgc caggctcaag agtacaaggc cctgctgaac atcaaggtca agctggaggc   1200

tgagagcact gcctactgct gcctgctgga ggatggcaag gacttcaatc ttggtgatgc   1260

cctggacagc agcaactcca tgcaaaccat ccaaaagacc accacccgcc ggatagtgga   1320

tggcaaagtg gtgtctgacc aacgacacca aagttctgag acattaa                 1367


<210>  625
<211>  8306
<212>  DNA
<213>  Homo sapiens

<400>  625
ggagagggag ggagggagag agagagagag ggagagagac ggatatctca ggtcatctgc     60

agctgcagcg agtctgagga gccgaggaag gcagggaaga tggcgatcct ccattgctga    120

gacccggcag aagcacatga gactcccaaa caacttccac aacaataacc cgagcaggaa    180

gaggagaaag agaaagagga taaggaggcg gtggggctgg agaacccgaa gcacctcccg    240

gcgccgggac gcttcttctg ttcctaatgt gagaggctag acccagatca tggaggtgct    300

tcagtgtgat ggctgtgatt tccgagcccc gtcttatgaa gatctcaagg cacacattca    360

ggatgtccac acggcatttc tgcagccaac tgatgttgct gaggacaatg tgaatgagct    420

acgatgtggg tccgtgaatg ccagtaatca gacagaggtg gagttttctt ctataaagga    480

tgaatttgcc attgcagaag atttatcagg tcaaaatgca acttcattgg ggaccggagg    540

ttactatggc cacagtccag gatattatgg tcagcatatt gccgctaatc ccaaaccaac    600

aaacaagttt tttcaatgca agttctgtgt acgctacttc aggtcaaaaa acctcctcat    660

agaacacact agaaaggtcc atggagctca agctgaaggg agttcatcag gaccccctgt    720

cccgggatcc ttaaattata atatcatgat gcacgaggga tttggaaagg tcttctcttg    780

ccagttttgc acatacaagt caccaagaag ggcaagaata attaagcatc agaagatgta    840

tcacaaaaac aatttgaagg agaccactgc tcccccacct gctcctgctc caatgccaga    900

ccctgtggtt ccgcccgtat cactgcagga cccctgcaag gaactgccag cagaggttgt    960

ggagcgcagc atcttagagt ctatggtcaa gcctttgacc aaatctcgag gcaacttttg   1020

ttgtgagtgg tgcagctacc agaccccccg ccgagaacgc tggtgtgacc acatgatgaa   1080

gaaacaccgc agtatggtca agatcctttc cagtctcaga cagcaacaag aaggaactaa   1140

tctacctgat gtgccgaaca agagtgcccc cagccccact tccaactcca cctatctgac   1200

catgaatgct gcaagccggg agatacccaa tactaccgtc tccaacttca ggggctccat   1260

gggcaactcc atcatgagac ccaattcttc agcttccaag ttttcgccca tgtcttaccc   1320

tcagatgaag ccgaagtcac ctcacaattc tggtctagtt aacttgacag agagatcccg   1380

ttatggaatg actgacatga ccaattcttc tgctgacctg gaaactaaca gcatgctaaa   1440

tgactctagt tctgatgaag agttaaatga aatagacagt gagaatggtt taagtgctat   1500

ggatcaccag acatcaggcc tgtctgcaga gcagctgatg ggctcagatg gcaacaaatt   1560

attggagacc aaggggattc catttagaag attcatgaat aggttccagt gccccttttg   1620

tcctttcctc accatgcatc gacgtagcat ctctcgtcac atagaaaaca tccacttatc   1680

tggaaagaca gctgtctaca aatgtgacga atgtccgttt acttgcaaga gctcgttgaa   1740

acttggggct cacaaacagt gtcacacggg tacaacgtca gattgggatg ctgtgaattc   1800

ccagagtgaa agcatttctt cctcactgaa tgaaggtgtg gtgtcttatg agagctcaag   1860

catcaatggt agaaagtcag gagtcatgtt ggatcccttg cagcagcaac agccaccgca   1920

gccaccacca ccgccgccgc caccaccacc atcacagcca cagccactgc agcagccaca   1980

gccaccacag ctgcagccac cacatcaggt gccaccccag ccacaaacac agccaccacc   2040

aacgcagcag ccacagccac ccacacaagc cgcacctctg cacccataca aatgcaccat   2100

gtgtaattac tccaccacaa ctctgaaagg gctaagagtc catcagcagc ataaacattc   2160

attctgtgac aacttgccaa aattcgaggg gcagccctca agcctaccat tggaaaatga   2220

gacagacagc cacccctctt ccagcaacac tgtgaagaaa agtcagacct caattcttgg   2280

gttgtcctcc aagaacaatt ttgtagctaa agcctctagg aagctcgcca atgactttcc   2340

tctagatttg tcacccgtga agaagagaac caggattgac gagatagcaa gcaaccttca   2400

gagcaaaatt aaccaaacca aacagcagga agatgcagtg atcaatgttg aggatgatga   2460

agaggaagag gaagacaacg aagtcgagat agaggttgag ttggacaggg aggaagaacc   2520

gacagaaccc atcatagagg ttcccacttc cttttctgcc caacagatat gggtaagaga   2580

taccagtgag ccccagaaag agcccaactt cagaaacatc acccacgatt acaatgccac   2640

caatggggct gagattgagc tcaccctttc tgaagatgaa gaggattatt atggctcctc   2700

aacaaacttg aaagatcacc aagtttccaa tactgctctg ctgaataccc aaactcccat   2760

ctatgggact gagcacaata gtgaaaacac agactttggt gactctggaa ggctttacta   2820

ttgtaaacac tgtgacttta acaacaaatc tgcccggagt gttagcaccc actaccaacg   2880

aatgcaccca tacattaaat tcagctttag gtacatcttg gaccccaatg atcacagtgc   2940

agtgtacagg tgcctggaat gctacatcga ttacaccaac ttcgaagatc tccagcagca   3000

ttatggcgag caccacccag aagccatgaa tgtactcaac tttgatcact cggacctgat   3060

ctaccggtgt cggttttgtt catacacgag cccgaatgtt agaagcctga tgccacatta   3120

ccaaagaatg catcccacgg tgaagatcaa caacgcgatg atattttcaa gctatgtcgt   3180

ggagcagcag gaagggctga atacagaatc ccagaccctg agggagattc tgaattcggc   3240

tcccaagaac atggcgactt ccacacctgt ggctcgtggt ggtggtttgc cagctacgtt   3300

caacaaaaac actcctaaga cctttactcc tgaatgtgaa aatcagaagg accctttggt   3360

caacactgtt gttgtttatg attgtgatgt ttgttcgttt gcaagcccca acatgcattc   3420

tgtcttggtt cattatcaga agaaacaccc cgaagaaaag gcttcctact ttaggatcca   3480

gaaaactatg cgaatggtgt ctgtggacag gggctctgcc ctttctcaat tatcatttga   3540

ggtgggtgct ccaatgtctc ccaaaatgtc caacatgggt tccccacccc ccccacaacc   3600

cccgccacca gacctcagta ctgagcttta ctactgcaaa cactgttcct acagcaatcg   3660

gtcagttgtg ggagtgcttg tccactacca gaaaagacac ccagaaataa aggttactgc   3720

caaatatatc agacaggctc ctcccacagc tgcaatgatg agaggggtcg aagggcccca   3780

aggctccccc cggccacccg cccccataca acagctgaac cgaagcagct ctgagagaga   3840

tggccctcct gtggagaatg agatgttctt ttgccagcac tgtgattatg ggaaccggac   3900

ggtcaaaggg gtactcattc attatcagaa gaagcaccga gacttcaagg ccaatgcaga   3960

tgtgatccgg cagcatacgg ccaccattcg aagcctctgc gaccgaaatc agaagaagcc   4020

tgccagctgc gtgcttgtct ccccctctaa tctggagcgg gacaaaacga aactccgagc   4080

actcaaatgt aggcagtgct catatacctc cccctacttc tatgcactga ggaagcatat   4140

caagaaagac caccccgccc tgaaagccac agtcacgtcc atcatgcgat gggcatttct   4200

agatggcttg atagaagctg gctaccactg cgagtggtgc atctactccc atacggagcc   4260

caacggtttg ctcctgcatt accaacggag gcatccagaa cactatgttg attacaccta   4320

catggctact aaactgtggg ctgggccaga cccatcccct ccctctctca caatgccagc   4380

cgaagccaaa acctacagat gcagggactg tgttttcgaa gctgtttcca tctgggacat   4440

cactaatcac taccaagcat tccacccctg ggccatgaat ggtgatgagt cagtgctact   4500

ggacatcatc aaggagaaag atgctgtgga gaagcccatt ctttcatccg aagagttggc   4560

aggccctgtg aattgtgaaa acagtatacc cacccctttc ccggagcagg aagctgaatg   4620

tccagaggat gcaagactgt cccctgagaa aagcctgcag ctagcttcag ccaaccccgc   4680

catatcctcc accccatacc agtgcacggt atgccaatct gagtataaca acttgcacgg   4740

ccttctcact cattatggga agaagcaccc tggcatgaaa gtgaaggctg ctgactttgc   4800

ccaggacatt gacatcaacc caggtgccgt ctacaaatgc aggcattgcc catacatcaa   4860

cacccgcatc cacggcgtac tgacccacta ccagaagcga cacccgtcca tcaaggtgac   4920

cgctgaggac tttgtgcacg acgtagagca gtctgctgac atatcccaga atgacgtgga   4980

ggagacgagc aggatcttca agcaagggta tggcgcctac cggtgcaaac tgtgtccgta   5040

cacacacggc actttggaga aactaaaaat ccactacgag aagtatcaca atcagcctga   5100

atttgatgtc ttttcccagt cgcccccgaa gctgccagtc cccctcgagc ccgagatgac   5160

cactgaagtg agcccttccc aagtctccat cactgaggag gaggtgggag aggagcccgt   5220

gtccacttct cacttctcta cctcccacct ggtctcccac actgtgttcc ggtgccagct   5280

ctgcaagtac ttctgctcca cgaggaaggg gatcgccagg cactaccgca tcaagcacaa   5340

taatgtccga gcccagccag aaggcaagaa caacctcttc aagtgtgccc tgtgtgccta   5400

caccaacccc atccgcaaag gtctggcagc ccactaccag aagcgccacg acattgatgc   5460

gtattacact cactgcttgg cagcctccag gaccatcagc gacaagccca acaaagtgat   5520

catcccatcc ccgcccaagg acgactcccc tcagctgagc gaggaactcc ggcgggcagt   5580

ggagaagaaa aagtgctcct tgtgctcttt ccagtcgttc agcaagaagg gcatcgtgtc   5640

ccattacatg aaacgccacc caggggtgtt cccaaagaag cagcacgcca gcaagttggg   5700

gggctacttc acggccgtct atgcagatga gcatgagaag cccacactga tggaagaaga   5760

ggagagaggc aactttgaga aagccgaggt ggagggtgaa gctcaggaaa tcgagtggct   5820

cccattccgc tgcatcaaat gcttcaagct gtcctttagc actgcagagc tgctgtgcat   5880

gcattacact gaccaccaca gtcgggacct aaagagggac ttcatcattc tgggcaacgg   5940

cccccgcttg cagaactcca cctaccagtg taagcactgt gatagcaaac tgcaaagcac   6000

agccgagctg acctcacact tgaacattca caatgaggaa ttccagaagc gtgccaaacg   6060

tcaggagagg aggaaacagc ttttgagcaa gcagaaatat gcagatggtg cttttgcaga   6120

tttcaaacaa gagaggcctt ttggtcactt agaagaggtg ccaaagatca aggagaggaa   6180

agtggtgggc tacaaatgta aattctgtgt ggaagtgcac ccaacgctcc gagccatctg   6240

caatcacctc cgaaagcacg tccagtatgg caatgtccca gctgtgtcag ctgctgtgaa   6300

ggggctgcgt tctcatgaga ggagccacct ggccctggcc atgtttaccc gcgaggacaa   6360

gtacagctgc cagtattgct cgtttgtttc tgctttcagg cacaatttgg atcgccatat   6420

gcaaacccac cacggacacc ataaaccatt ccgatgcaaa ctctgctcct tcaagtcctc   6480

ctataacagc cggctgaaaa cacatatact caaagctcat gctggtgagc atgcctacaa   6540

gtgttcttgg tgctcattct ccaccatgac aatcagccag ctgaaggaac actccctcaa   6600

ggtccacgga aaagccctga ccctccccag gccacggatc gtcagtctcc tctcctcaca   6660

ctcccaccac tcctcccaaa aagctacccc ggctgaagaa gtggaagact ccaatgactc   6720

atcatattca gagcccccag atgttcagca gcagttgaac cactatcagt cagctgccct   6780

ggcaaggaac aacagccgtg ttagccctgt gcctctttct ggggctgctg ctggcactga   6840

gcagaaaact gaagccgtgc ttcactgcga attctgtgaa ttctcctccg gctacatcca   6900

gagcatcagg cgtcattacc gggacaagca tggtgggaag aagcttttca agtgcaaaga   6960

ctgctccttt tacacaggct ttaaatctgc ttttactatg cacgtggaag ctgggcactc   7020

agcagttccc gaggagggcc ccaaagatct tcgctgtcct ctctgcctct atcacaccaa   7080

atacaagcgc aacatgattg accacatcgt gctgcaccga gaagagcgtg ttgtccccat   7140

tgaagtttgc cggtccaaac tgtccaaata cttgcaggga gtagttttcc gctgtgataa   7200

gtgtaccttc acctgctcca gtgatgagag cctccagcaa catatagaaa agcacaatga   7260

actgaaacct tacaaatgcc agctctgcta ctatgagacc aagcacacgg aggaactgga   7320

cagccacctt cgggatgagc ataaggtaag ccgtaacttt gagctggttg gacgggttaa   7380

cttggatcag ctggaacaga tgaaggagaa aatggagagc tccagcagcg atgatgagga   7440

caaggaagaa gaaatgaaca gcaaggctga agacagagag ctgatgagat tttctgacca   7500

cggggctgct cttaacactg agaagcgttt tccatgtgaa ttttgtggac gggcgttttc   7560

acagggctct gagtgggaaa gacatgtgct gagacacggc atggcattga atgacaccaa   7620

gcaggtgagc agagaagaaa tccacccaaa agagatcatg gagaacagtg ttaaaatgcc   7680

ctccatagag gaaaaggaag atgacgaggc cattgggata gacttttccc taaagaatga   7740

aacagtagcc atctgtgtag taactgccga caaatctctc ctggagaatg cagaggccaa   7800

aaaagaatga gcgtttggtg aaattcttaa tcaaacctta cttgaacagt gatgaaaaag   7860

tgggagggct ggcttgggct gagaagggag ggacagaaaa gagaagacag aacaaagctg   7920

ctttttagga ctgaacaatc tattttcaaa gcactggtac ctgtgtgagt gagtatgtaa   7980

attaaagtta tttaaatggt tggaatatgt ggctcctttt ccatcactac atcttttctt   8040

ccggatcttc atcatggaag tttcatttgt tgcggaatat ggaagcacct cccaatggta   8100

cggtgcaccc tgtggtggtc ttggacagta tgtggaaaca gaagctccat gacggtagaa   8160

gacttctcat tggggagcaa ctttttgacg cacaactttt ggtgcgtttt tctagtttta   8220

ataccttaag ctttttcaag acctaactgc agccgctttg ggaaaaaaaa acaaaaaaca   8280

aaaaacagaa aacaaaaaaa aaaaaa                                        8306


<210>  626
<211>  2506
<212>  PRT
<213>  Homo sapiens

<400>  626

Met Glu Val Leu Gln Cys Asp Gly Cys Asp Phe Arg Ala Pro Ser Tyr 
1               5                   10                  15


Glu Asp Leu Lys Ala His Ile Gln Asp Val His Thr Ala Phe Leu Gln 
            20                  25                  30


Pro Thr Asp Val Ala Glu Asp Asn Val Asn Glu Leu Arg Cys Gly Ser 
        35                  40                  45


Val Asn Ala Ser Asn Gln Thr Glu Val Glu Phe Ser Ser Ile Lys Asp 
    50                  55                  60


Glu Phe Ala Ile Ala Glu Asp Leu Ser Gly Gln Asn Ala Thr Ser Leu 
65                  70                  75                  80


Gly Thr Gly Gly Tyr Tyr Gly His Ser Pro Gly Tyr Tyr Gly Gln His 
                85                  90                  95


Ile Ala Ala Asn Pro Lys Pro Thr Asn Lys Phe Phe Gln Cys Lys Phe 
            100                 105                 110


Cys Val Arg Tyr Phe Arg Ser Lys Asn Leu Leu Ile Glu His Thr Arg 
        115                 120                 125


Lys Val His Gly Ala Gln Ala Glu Gly Ser Ser Ser Gly Pro Pro Val 
    130                 135                 140


Pro Gly Ser Leu Asn Tyr Asn Ile Met Met His Glu Gly Phe Gly Lys 
145                 150                 155                 160


Val Phe Ser Cys Gln Phe Cys Thr Tyr Lys Ser Pro Arg Arg Ala Arg 
                165                 170                 175


Ile Ile Lys His Gln Lys Met Tyr His Lys Asn Asn Leu Lys Glu Thr 
            180                 185                 190


Thr Ala Pro Pro Pro Ala Pro Ala Pro Met Pro Asp Pro Val Val Pro 
        195                 200                 205


Pro Val Ser Leu Gln Asp Pro Cys Lys Glu Leu Pro Ala Glu Val Val 
    210                 215                 220


Glu Arg Ser Ile Leu Glu Ser Met Val Lys Pro Leu Thr Lys Ser Arg 
225                 230                 235                 240


Gly Asn Phe Cys Cys Glu Trp Cys Ser Tyr Gln Thr Pro Arg Arg Glu 
                245                 250                 255


Arg Trp Cys Asp His Met Met Lys Lys His Arg Ser Met Val Lys Ile 
            260                 265                 270


Leu Ser Ser Leu Arg Gln Gln Gln Glu Gly Thr Asn Leu Pro Asp Val 
        275                 280                 285


Pro Asn Lys Ser Ala Pro Ser Pro Thr Ser Asn Ser Thr Tyr Leu Thr 
    290                 295                 300


Met Asn Ala Ala Ser Arg Glu Ile Pro Asn Thr Thr Val Ser Asn Phe 
305                 310                 315                 320


Arg Gly Ser Met Gly Asn Ser Ile Met Arg Pro Asn Ser Ser Ala Ser 
                325                 330                 335


Lys Phe Ser Pro Met Ser Tyr Pro Gln Met Lys Pro Lys Ser Pro His 
            340                 345                 350


Asn Ser Gly Leu Val Asn Leu Thr Glu Arg Ser Arg Tyr Gly Met Thr 
        355                 360                 365


Asp Met Thr Asn Ser Ser Ala Asp Leu Glu Thr Asn Ser Met Leu Asn 
    370                 375                 380


Asp Ser Ser Ser Asp Glu Glu Leu Asn Glu Ile Asp Ser Glu Asn Gly 
385                 390                 395                 400


Leu Ser Ala Met Asp His Gln Thr Ser Gly Leu Ser Ala Glu Gln Leu 
                405                 410                 415


Met Gly Ser Asp Gly Asn Lys Leu Leu Glu Thr Lys Gly Ile Pro Phe 
            420                 425                 430


Arg Arg Phe Met Asn Arg Phe Gln Cys Pro Phe Cys Pro Phe Leu Thr 
        435                 440                 445


Met His Arg Arg Ser Ile Ser Arg His Ile Glu Asn Ile His Leu Ser 
    450                 455                 460


Gly Lys Thr Ala Val Tyr Lys Cys Asp Glu Cys Pro Phe Thr Cys Lys 
465                 470                 475                 480


Ser Ser Leu Lys Leu Gly Ala His Lys Gln Cys His Thr Gly Thr Thr 
                485                 490                 495


Ser Asp Trp Asp Ala Val Asn Ser Gln Ser Glu Ser Ile Ser Ser Ser 
            500                 505                 510


Leu Asn Glu Gly Val Val Ser Tyr Glu Ser Ser Ser Ile Asn Gly Arg 
        515                 520                 525


Lys Ser Gly Val Met Leu Asp Pro Leu Gln Gln Gln Gln Pro Pro Gln 
    530                 535                 540


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ser Gln Pro Gln Pro Leu 
545                 550                 555                 560


Gln Gln Pro Gln Pro Pro Gln Leu Gln Pro Pro His Gln Val Pro Pro 
                565                 570                 575


Gln Pro Gln Thr Gln Pro Pro Pro Thr Gln Gln Pro Gln Pro Pro Thr 
            580                 585                 590


Gln Ala Ala Pro Leu His Pro Tyr Lys Cys Thr Met Cys Asn Tyr Ser 
        595                 600                 605


Thr Thr Thr Leu Lys Gly Leu Arg Val His Gln Gln His Lys His Ser 
    610                 615                 620


Phe Cys Asp Asn Leu Pro Lys Phe Glu Gly Gln Pro Ser Ser Leu Pro 
625                 630                 635                 640


Leu Glu Asn Glu Thr Asp Ser His Pro Ser Ser Ser Asn Thr Val Lys 
                645                 650                 655


Lys Ser Gln Thr Ser Ile Leu Gly Leu Ser Ser Lys Asn Asn Phe Val 
            660                 665                 670


Ala Lys Ala Ser Arg Lys Leu Ala Asn Asp Phe Pro Leu Asp Leu Ser 
        675                 680                 685


Pro Val Lys Lys Arg Thr Arg Ile Asp Glu Ile Ala Ser Asn Leu Gln 
    690                 695                 700


Ser Lys Ile Asn Gln Thr Lys Gln Gln Glu Asp Ala Val Ile Asn Val 
705                 710                 715                 720


Glu Asp Asp Glu Glu Glu Glu Glu Asp Asn Glu Val Glu Ile Glu Val 
                725                 730                 735


Glu Leu Asp Arg Glu Glu Glu Pro Thr Glu Pro Ile Ile Glu Val Pro 
            740                 745                 750


Thr Ser Phe Ser Ala Gln Gln Ile Trp Val Arg Asp Thr Ser Glu Pro 
        755                 760                 765


Gln Lys Glu Pro Asn Phe Arg Asn Ile Thr His Asp Tyr Asn Ala Thr 
    770                 775                 780


Asn Gly Ala Glu Ile Glu Leu Thr Leu Ser Glu Asp Glu Glu Asp Tyr 
785                 790                 795                 800


Tyr Gly Ser Ser Thr Asn Leu Lys Asp His Gln Val Ser Asn Thr Ala 
                805                 810                 815


Leu Leu Asn Thr Gln Thr Pro Ile Tyr Gly Thr Glu His Asn Ser Glu 
            820                 825                 830


Asn Thr Asp Phe Gly Asp Ser Gly Arg Leu Tyr Tyr Cys Lys His Cys 
        835                 840                 845


Asp Phe Asn Asn Lys Ser Ala Arg Ser Val Ser Thr His Tyr Gln Arg 
    850                 855                 860


Met His Pro Tyr Ile Lys Phe Ser Phe Arg Tyr Ile Leu Asp Pro Asn 
865                 870                 875                 880


Asp His Ser Ala Val Tyr Arg Cys Leu Glu Cys Tyr Ile Asp Tyr Thr 
                885                 890                 895


Asn Phe Glu Asp Leu Gln Gln His Tyr Gly Glu His His Pro Glu Ala 
            900                 905                 910


Met Asn Val Leu Asn Phe Asp His Ser Asp Leu Ile Tyr Arg Cys Arg 
        915                 920                 925


Phe Cys Ser Tyr Thr Ser Pro Asn Val Arg Ser Leu Met Pro His Tyr 
    930                 935                 940


Gln Arg Met His Pro Thr Val Lys Ile Asn Asn Ala Met Ile Phe Ser 
945                 950                 955                 960


Ser Tyr Val Val Glu Gln Gln Glu Gly Leu Asn Thr Glu Ser Gln Thr 
                965                 970                 975


Leu Arg Glu Ile Leu Asn Ser Ala Pro Lys Asn Met Ala Thr Ser Thr 
            980                 985                 990


Pro Val Ala Arg Gly Gly Gly Leu Pro Ala Thr Phe Asn Lys Asn Thr 
        995                 1000                1005


Pro Lys Thr Phe Thr Pro Glu Cys Glu Asn Gln Lys Asp Pro Leu Val 
    1010                1015                1020


Asn Thr Val Val Val Tyr Asp Cys Asp Val Cys Ser Phe Ala Ser Pro 
1025                1030                1035                1040


Asn Met His Ser Val Leu Val His Tyr Gln Lys Lys His Pro Glu Glu 
                1045                1050                1055


Lys Ala Ser Tyr Phe Arg Ile Gln Lys Thr Met Arg Met Val Ser Val 
            1060                1065                1070


Asp Arg Gly Ser Ala Leu Ser Gln Leu Ser Phe Glu Val Gly Ala Pro 
        1075                1080                1085


Met Ser Pro Lys Met Ser Asn Met Gly Ser Pro Pro Pro Pro Gln Pro 
    1090                1095                1100


Pro Pro Pro Asp Leu Ser Thr Glu Leu Tyr Tyr Cys Lys His Cys Ser 
1105                1110                1115                1120


Tyr Ser Asn Arg Ser Val Val Gly Val Leu Val His Tyr Gln Lys Arg 
                1125                1130                1135


His Pro Glu Ile Lys Val Thr Ala Lys Tyr Ile Arg Gln Ala Pro Pro 
            1140                1145                1150


Thr Ala Ala Met Met Arg Gly Val Glu Gly Pro Gln Gly Ser Pro Arg 
        1155                1160                1165


Pro Pro Ala Pro Ile Gln Gln Leu Asn Arg Ser Ser Ser Glu Arg Asp 
    1170                1175                1180


Gly Pro Pro Val Glu Asn Glu Met Phe Phe Cys Gln His Cys Asp Tyr 
1185                1190                1195                1200


Gly Asn Arg Thr Val Lys Gly Val Leu Ile His Tyr Gln Lys Lys His 
                1205                1210                1215


Arg Asp Phe Lys Ala Asn Ala Asp Val Ile Arg Gln His Thr Ala Thr 
            1220                1225                1230


Ile Arg Ser Leu Cys Asp Arg Asn Gln Lys Lys Pro Ala Ser Cys Val 
        1235                1240                1245


Leu Val Ser Pro Ser Asn Leu Glu Arg Asp Lys Thr Lys Leu Arg Ala 
    1250                1255                1260


Leu Lys Cys Arg Gln Cys Ser Tyr Thr Ser Pro Tyr Phe Tyr Ala Leu 
1265                1270                1275                1280


Arg Lys His Ile Lys Lys Asp His Pro Ala Leu Lys Ala Thr Val Thr 
                1285                1290                1295


Ser Ile Met Arg Trp Ala Phe Leu Asp Gly Leu Ile Glu Ala Gly Tyr 
            1300                1305                1310


His Cys Glu Trp Cys Ile Tyr Ser His Thr Glu Pro Asn Gly Leu Leu 
        1315                1320                1325


Leu His Tyr Gln Arg Arg His Pro Glu His Tyr Val Asp Tyr Thr Tyr 
    1330                1335                1340


Met Ala Thr Lys Leu Trp Ala Gly Pro Asp Pro Ser Pro Pro Ser Leu 
1345                1350                1355                1360


Thr Met Pro Ala Glu Ala Lys Thr Tyr Arg Cys Arg Asp Cys Val Phe 
                1365                1370                1375


Glu Ala Val Ser Ile Trp Asp Ile Thr Asn His Tyr Gln Ala Phe His 
            1380                1385                1390


Pro Trp Ala Met Asn Gly Asp Glu Ser Val Leu Leu Asp Ile Ile Lys 
        1395                1400                1405


Glu Lys Asp Ala Val Glu Lys Pro Ile Leu Ser Ser Glu Glu Leu Ala 
    1410                1415                1420


Gly Pro Val Asn Cys Glu Asn Ser Ile Pro Thr Pro Phe Pro Glu Gln 
1425                1430                1435                1440


Glu Ala Glu Cys Pro Glu Asp Ala Arg Leu Ser Pro Glu Lys Ser Leu 
                1445                1450                1455


Gln Leu Ala Ser Ala Asn Pro Ala Ile Ser Ser Thr Pro Tyr Gln Cys 
            1460                1465                1470


Thr Val Cys Gln Ser Glu Tyr Asn Asn Leu His Gly Leu Leu Thr His 
        1475                1480                1485


Tyr Gly Lys Lys His Pro Gly Met Lys Val Lys Ala Ala Asp Phe Ala 
    1490                1495                1500


Gln Asp Ile Asp Ile Asn Pro Gly Ala Val Tyr Lys Cys Arg His Cys 
1505                1510                1515                1520


Pro Tyr Ile Asn Thr Arg Ile His Gly Val Leu Thr His Tyr Gln Lys 
                1525                1530                1535


Arg His Pro Ser Ile Lys Val Thr Ala Glu Asp Phe Val His Asp Val 
            1540                1545                1550


Glu Gln Ser Ala Asp Ile Ser Gln Asn Asp Val Glu Glu Thr Ser Arg 
        1555                1560                1565


Ile Phe Lys Gln Gly Tyr Gly Ala Tyr Arg Cys Lys Leu Cys Pro Tyr 
    1570                1575                1580


Thr His Gly Thr Leu Glu Lys Leu Lys Ile His Tyr Glu Lys Tyr His 
1585                1590                1595                1600


Asn Gln Pro Glu Phe Asp Val Phe Ser Gln Ser Pro Pro Lys Leu Pro 
                1605                1610                1615


Val Pro Leu Glu Pro Glu Met Thr Thr Glu Val Ser Pro Ser Gln Val 
            1620                1625                1630


Ser Ile Thr Glu Glu Glu Val Gly Glu Glu Pro Val Ser Thr Ser His 
        1635                1640                1645


Phe Ser Thr Ser His Leu Val Ser His Thr Val Phe Arg Cys Gln Leu 
    1650                1655                1660


Cys Lys Tyr Phe Cys Ser Thr Arg Lys Gly Ile Ala Arg His Tyr Arg 
1665                1670                1675                1680


Ile Lys His Asn Asn Val Arg Ala Gln Pro Glu Gly Lys Asn Asn Leu 
                1685                1690                1695


Phe Lys Cys Ala Leu Cys Ala Tyr Thr Asn Pro Ile Arg Lys Gly Leu 
            1700                1705                1710


Ala Ala His Tyr Gln Lys Arg His Asp Ile Asp Ala Tyr Tyr Thr His 
        1715                1720                1725


Cys Leu Ala Ala Ser Arg Thr Ile Ser Asp Lys Pro Asn Lys Val Ile 
    1730                1735                1740


Ile Pro Ser Pro Pro Lys Asp Asp Ser Pro Gln Leu Ser Glu Glu Leu 
1745                1750                1755                1760


Arg Arg Ala Val Glu Lys Lys Lys Cys Ser Leu Cys Ser Phe Gln Ser 
                1765                1770                1775


Phe Ser Lys Lys Gly Ile Val Ser His Tyr Met Lys Arg His Pro Gly 
            1780                1785                1790


Val Phe Pro Lys Lys Gln His Ala Ser Lys Leu Gly Gly Tyr Phe Thr 
        1795                1800                1805


Ala Val Tyr Ala Asp Glu His Glu Lys Pro Thr Leu Met Glu Glu Glu 
    1810                1815                1820


Glu Arg Gly Asn Phe Glu Lys Ala Glu Val Glu Gly Glu Ala Gln Glu 
1825                1830                1835                1840


Ile Glu Trp Leu Pro Phe Arg Cys Ile Lys Cys Phe Lys Leu Ser Phe 
                1845                1850                1855


Ser Thr Ala Glu Leu Leu Cys Met His Tyr Thr Asp His His Ser Arg 
            1860                1865                1870


Asp Leu Lys Arg Asp Phe Ile Ile Leu Gly Asn Gly Pro Arg Leu Gln 
        1875                1880                1885


Asn Ser Thr Tyr Gln Cys Lys His Cys Asp Ser Lys Leu Gln Ser Thr 
    1890                1895                1900


Ala Glu Leu Thr Ser His Leu Asn Ile His Asn Glu Glu Phe Gln Lys 
1905                1910                1915                1920


Arg Ala Lys Arg Gln Glu Arg Arg Lys Gln Leu Leu Ser Lys Gln Lys 
                1925                1930                1935


Tyr Ala Asp Gly Ala Phe Ala Asp Phe Lys Gln Glu Arg Pro Phe Gly 
            1940                1945                1950


His Leu Glu Glu Val Pro Lys Ile Lys Glu Arg Lys Val Val Gly Tyr 
        1955                1960                1965


Lys Cys Lys Phe Cys Val Glu Val His Pro Thr Leu Arg Ala Ile Cys 
    1970                1975                1980


Asn His Leu Arg Lys His Val Gln Tyr Gly Asn Val Pro Ala Val Ser 
1985                1990                1995                2000


Ala Ala Val Lys Gly Leu Arg Ser His Glu Arg Ser His Leu Ala Leu 
                2005                2010                2015


Ala Met Phe Thr Arg Glu Asp Lys Tyr Ser Cys Gln Tyr Cys Ser Phe 
            2020                2025                2030


Val Ser Ala Phe Arg His Asn Leu Asp Arg His Met Gln Thr His His 
        2035                2040                2045


Gly His His Lys Pro Phe Arg Cys Lys Leu Cys Ser Phe Lys Ser Ser 
    2050                2055                2060


Tyr Asn Ser Arg Leu Lys Thr His Ile Leu Lys Ala His Ala Gly Glu 
2065                2070                2075                2080


His Ala Tyr Lys Cys Ser Trp Cys Ser Phe Ser Thr Met Thr Ile Ser 
                2085                2090                2095


Gln Leu Lys Glu His Ser Leu Lys Val His Gly Lys Ala Leu Thr Leu 
            2100                2105                2110


Pro Arg Pro Arg Ile Val Ser Leu Leu Ser Ser His Ser His His Ser 
        2115                2120                2125


Ser Gln Lys Ala Thr Pro Ala Glu Glu Val Glu Asp Ser Asn Asp Ser 
    2130                2135                2140


Ser Tyr Ser Glu Pro Pro Asp Val Gln Gln Gln Leu Asn His Tyr Gln 
2145                2150                2155                2160


Ser Ala Ala Leu Ala Arg Asn Asn Ser Arg Val Ser Pro Val Pro Leu 
                2165                2170                2175


Ser Gly Ala Ala Ala Gly Thr Glu Gln Lys Thr Glu Ala Val Leu His 
            2180                2185                2190


Cys Glu Phe Cys Glu Phe Ser Ser Gly Tyr Ile Gln Ser Ile Arg Arg 
        2195                2200                2205


His Tyr Arg Asp Lys His Gly Gly Lys Lys Leu Phe Lys Cys Lys Asp 
    2210                2215                2220


Cys Ser Phe Tyr Thr Gly Phe Lys Ser Ala Phe Thr Met His Val Glu 
2225                2230                2235                2240


Ala Gly His Ser Ala Val Pro Glu Glu Gly Pro Lys Asp Leu Arg Cys 
                2245                2250                2255


Pro Leu Cys Leu Tyr His Thr Lys Tyr Lys Arg Asn Met Ile Asp His 
            2260                2265                2270


Ile Val Leu His Arg Glu Glu Arg Val Val Pro Ile Glu Val Cys Arg 
        2275                2280                2285


Ser Lys Leu Ser Lys Tyr Leu Gln Gly Val Val Phe Arg Cys Asp Lys 
    2290                2295                2300


Cys Thr Phe Thr Cys Ser Ser Asp Glu Ser Leu Gln Gln His Ile Glu 
2305                2310                2315                2320


Lys His Asn Glu Leu Lys Pro Tyr Lys Cys Gln Leu Cys Tyr Tyr Glu 
                2325                2330                2335


Thr Lys His Thr Glu Glu Leu Asp Ser His Leu Arg Asp Glu His Lys 
            2340                2345                2350


Val Ser Arg Asn Phe Glu Leu Val Gly Arg Val Asn Leu Asp Gln Leu 
        2355                2360                2365


Glu Gln Met Lys Glu Lys Met Glu Ser Ser Ser Ser Asp Asp Glu Asp 
    2370                2375                2380


Lys Glu Glu Glu Met Asn Ser Lys Ala Glu Asp Arg Glu Leu Met Arg 
2385                2390                2395                2400


Phe Ser Asp His Gly Ala Ala Leu Asn Thr Glu Lys Arg Phe Pro Cys 
                2405                2410                2415


Glu Phe Cys Gly Arg Ala Phe Ser Gln Gly Ser Glu Trp Glu Arg His 
            2420                2425                2430


Val Leu Arg His Gly Met Ala Leu Asn Asp Thr Lys Gln Val Ser Arg 
        2435                2440                2445


Glu Glu Ile His Pro Lys Glu Ile Met Glu Asn Ser Val Lys Met Pro 
    2450                2455                2460


Ser Ile Glu Glu Lys Glu Asp Asp Glu Ala Ile Gly Ile Asp Phe Ser 
2465                2470                2475                2480


Leu Lys Asn Glu Thr Val Ala Ile Cys Val Val Thr Ala Asp Lys Ser 
                2485                2490                2495


Leu Leu Glu Asn Ala Glu Ala Lys Lys Glu 
            2500                2505


<210>  627
<211>  3151
<212>  DNA
<213>  Homo sapiens

<400>  627
gctcttacgc ggtctgtggg agaccggagc gggagacagc ggtgacagga gcagcggccg     60

ggagccctta gggaggcaga cagagcctgc agccaatgcc ccaggagccc tcggttccaa    120

ccaactgatg cccctgtgcc cactggccca cgccatgcag ccccagtccg ttctgcacag    180

cggctacttc cacccactac ttcgggcctg gcagacagcc accaccaccc tcaatgcctc    240

caacctcatc taccccatct ttgtcacgga tgttcctgat gacatacagc ctatcaccag    300

cctcccagga gtggccaggt atggtgtgaa gcggctggaa gagatgctga ggcccttggt    360

ggaagagggc ctacgctgtg tcttgatctt tggcgtcccc agcagagttc ccaaggacga    420

gcggggttcc gcagctgact ccgaggagtc cccagctatt gaggcaatcc atctgttgag    480

gaagaccttc cccaacctcc tggtggcctg tgatgtctgc ctgtgtccct acacctccca    540

tggtcactgc gggctcctga gtgaaaacgg agcattccgg gctgaggaga gccgccagcg    600

gctggctgag gtggcattgg cgtatgccaa ggcaggatgt caggtggtag ccccgtcgga    660

catgatggat ggacgcgtgg aagccatcaa agaggccctg atggcacatg gacttggcaa    720

cagggtatcg gtgatgagct acagtgccaa atttgcttcc tgtttctatg gccctttccg    780

ggatgcagct aagtcaagcc cagcttttgg ggaccgccgc tgctaccagc tgccccctgg    840

agcacgaggc ctggctctcc gagctgtgga ccgggatgta cgggaaggag ctgacatgct    900

catggtgaag ccgggaatgc cctacctgga catcgtgcgg gaggtaaagg acaagcaccc    960

tgacctccct ctcgccgtgt accacgtctc tggagagttt gccatgctgt ggcatggagc   1020

ccaggccggg gcatttgatc tcaaggctgc cgtactggag gccatgactg ccttccgcag   1080

agcaggtgct gacatcatca tcacctacta cacaccgcag ctgctgcagt ggctgaagga   1140

ggaatgatgg agacagtgcc aggcccaaga actagaactt taaaacgttc ccggggcctc   1200

agacaagtga aaaccaaagt aaatgctgct tttagaactg tgccctcatg ccctcttcct   1260

gctcacatgc tagcggggcc cagcagccct gggtggtttt gccagcatgc taactcttgt   1320

aactcgcagc tgcatcctat gagctctccc aagcttcccc gcccctcccc tgggtcagcc   1380

gtgaggccca cctttgccac cctcagctct ttcctctggt gtggcttcag cttgaaagca   1440

acctggagtc gggggcacag cctttggggc ctggctggga gagggtcttg gagcattagg   1500

ggaagaagag agcagtggga tcttggggcc tgagaagcct tggaacgctt ctggcagcag   1560

agctgggtgt gggaatgagg cctagatcga tatccctggg ttagagttga aatttgccgc   1620

aattccactg gaaggcattt cccacgaggc cagaggttgc caggctgcct gaggtctcct   1680

attctactct gaaccataaa cccagagaag aattactcat taaccagcat aaatactgcc   1740

tgaggatcaa aactcagagg caaagaggga gttcctgact gctagaggtg ccaccaccac   1800

aaacactttt tattcaggag atactttttg agaatctctg ctctgttcct aggttcagtg   1860

ctgggtcctg ggaatacagc aggacagacc tcagcttatc tcttcataga aattatacaa   1920

agagaattgg ggagacagct aagaagaaaa caaagaaata aagcagttac aaattgtgat   1980

aagtgctttg aaggaaagaa ggggtctgag acaacaacag ggaaggggcc tctcttgaaa   2040

cagtagttgg gaaggaggca gacatgcacc agtgatgtgg tgacaggtgc tctgaaggag   2100

gtcaccagga cctgacctct ttgaaggatc agaaaatact tccctgaagg actgacattt   2160

gagcctagac ctgaagggtg agccatcaag ctaagacaat tggggaagag cattccaggg   2220

agagggagga gttgtgcaaa ggccctgggg ctccttctag ctggaggaat gcaaggctag   2280

cttgtctgga gcactgagag gatggcctga actgagtgga gagagacaga ccaggaccaa   2340

accatgcaga ggtcaagggc cacattcacc ttttcagagt gactcaatca aatttgtagt   2400

ttgtaaaagt attttaacag ctctgcggca aagtgcaaat gaaaagtctt gatggcatgg   2460

actggagcgg ggacagtggg gatggagaaa ggggaatgga ttgtggatgt gtttagaagg   2520

tagattcgat gtgaaggatg aatctggctt gaccttctgg gtggctgatg ggccatttac   2580

tgagatgggg cagcctggaa gaggaacaga agcagggtcg gggtggaggg agaatactaa   2640

acttagcttg agacattttg caataaggaa gctatatcta gagtgcttat gtgactcacc   2700

taaggccact caacaagttt gtggcagaac tggattagaa ctgcacagaa aacagccaag   2760

ctgggatttg aacccatgta gtccaactcc aaggcctctg cccctaacca ctgtgccata   2820

ccacctccca ataatcaaca gcaaaattat aggtctaaca atgttttata gacacccctc   2880

catttatgtg atgggtttgc atcctgataa acccatcata agttgaaaat atgatcataa   2940

gttgaaaata tgatcataag tcaaaaatgt atttaatata cctaacctac caaacatcat   3000

agcttagcct agcctgcctt aaacatgctc agaacactta cattagccta cagtgggcaa   3060

aactatccaa cacaaaatct atattgtaat aaagttgtaa agaattttga ataaaaattc   3120

aatatttgaa gtacaaaaaa aaaaaaaaaa a                                  3151


<210>  628
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  628

Met Pro Leu Cys Pro Leu Ala His Ala Met Gln Pro Gln Ser Val Leu 
1               5                   10                  15


His Ser Gly Tyr Phe His Pro Leu Leu Arg Ala Trp Gln Thr Ala Thr 
            20                  25                  30


Thr Thr Leu Asn Ala Ser Asn Leu Ile Tyr Pro Ile Phe Val Thr Asp 
        35                  40                  45


Val Pro Asp Asp Ile Gln Pro Ile Thr Ser Leu Pro Gly Val Ala Arg 
    50                  55                  60


Tyr Gly Val Lys Arg Leu Glu Glu Met Leu Arg Pro Leu Val Glu Glu 
65                  70                  75                  80


Gly Leu Arg Cys Val Leu Ile Phe Gly Val Pro Ser Arg Val Pro Lys 
                85                  90                  95


Asp Glu Arg Gly Ser Ala Ala Asp Ser Glu Glu Ser Pro Ala Ile Glu 
            100                 105                 110


Ala Ile His Leu Leu Arg Lys Thr Phe Pro Asn Leu Leu Val Ala Cys 
        115                 120                 125


Asp Val Cys Leu Cys Pro Tyr Thr Ser His Gly His Cys Gly Leu Leu 
    130                 135                 140


Ser Glu Asn Gly Ala Phe Arg Ala Glu Glu Ser Arg Gln Arg Leu Ala 
145                 150                 155                 160


Glu Val Ala Leu Ala Tyr Ala Lys Ala Gly Cys Gln Val Val Ala Pro 
                165                 170                 175


Ser Asp Met Met Asp Gly Arg Val Glu Ala Ile Lys Glu Ala Leu Met 
            180                 185                 190


Ala His Gly Leu Gly Asn Arg Val Ser Val Met Ser Tyr Ser Ala Lys 
        195                 200                 205


Phe Ala Ser Cys Phe Tyr Gly Pro Phe Arg Asp Ala Ala Lys Ser Ser 
    210                 215                 220


Pro Ala Phe Gly Asp Arg Arg Cys Tyr Gln Leu Pro Pro Gly Ala Arg 
225                 230                 235                 240


Gly Leu Ala Leu Arg Ala Val Asp Arg Asp Val Arg Glu Gly Ala Asp 
                245                 250                 255


Met Leu Met Val Lys Pro Gly Met Pro Tyr Leu Asp Ile Val Arg Glu 
            260                 265                 270


Val Lys Asp Lys His Pro Asp Leu Pro Leu Ala Val Tyr His Val Ser 
        275                 280                 285


Gly Glu Phe Ala Met Leu Trp His Gly Ala Gln Ala Gly Ala Phe Asp 
    290                 295                 300


Leu Lys Ala Ala Val Leu Glu Ala Met Thr Ala Phe Arg Arg Ala Gly 
305                 310                 315                 320


Ala Asp Ile Ile Ile Thr Tyr Tyr Thr Pro Gln Leu Leu Gln Trp Leu 
                325                 330                 335


Lys Glu Glu 



<210>  629
<211>  3317
<212>  DNA
<213>  Homo sapiens

<400>  629
gctcttacgc ggtctgtggg agaccggagc gggagacagc ggtgacagga gcagcggccg     60

ggagccctta gggaggcaga cagagcctgc agccaatgcc ccaggagccc tcggttccaa    120

ccaactgatg cccctgtgcc cactggccca cgccatgcag ccccagtccg ttctgcacag    180

cggctacttc cacccactac ttcgggcctg gcagacagcc accaccaccc tcaatgcctc    240

caacctcatc taccccatct ttgtcacgcc ctgggcttgg ccaggcaggg aagccagaca    300

ctggatccca tcctcctccc accatctcca cttccatatt tctttcctgc ttcccaacca    360

tccctctcag tcgcccccgc accactggcc cttcccacag ctaccaatcc atatcccacc    420

cccgctcttg cagggatgtt cctgatgaca tacagcctat caccagcctc ccaggagtgg    480

ccaggtatgg tgtgaagcgg ctggaagaga tgctgaggcc cttggtggaa gagggcctac    540

gctgtgtctt gatctttggc gtccccagca gagttcccaa ggacgagcgg ggttccgcag    600

ctgactccga ggagtcccca gctattgagg caatccatct gttgaggaag accttcccca    660

acctcctggt ggcctgtgat gtctgcctgt gtccctacac ctcccatggt cactgcgggc    720

tcctgagtga aaacggagca ttccgggctg aggagagccg ccagcggctg gctgaggtgg    780

cattggcgta tgccaaggca ggatgtcagg tggtagcccc gtcggacatg atggatggac    840

gcgtggaagc catcaaagag gccctgatgg cacatggact tggcaacagg gtatcggtga    900

tgagctacag tgccaaattt gcttcctgtt tctatggccc tttccgggat gcagctaagt    960

caagcccagc ttttggggac cgccgctgct accagctgcc ccctggagca cgaggcctgg   1020

ctctccgagc tgtggaccgg gatgtacggg aaggagctga catgctcatg gtgaagccgg   1080

gaatgcccta cctggacatc gtgcgggagg taaaggacaa gcaccctgac ctccctctcg   1140

ccgtgtacca cgtctctgga gagtttgcca tgctgtggca tggagcccag gccggggcat   1200

ttgatctcaa ggctgccgta ctggaggcca tgactgcctt ccgcagagca ggtgctgaca   1260

tcatcatcac ctactacaca ccgcagctgc tgcagtggct gaaggaggaa tgatggagac   1320

agtgccaggc ccaagaacta gaactttaaa acgttcccgg ggcctcagac aagtgaaaac   1380

caaagtaaat gctgctttta gaactgtgcc ctcatgccct cttcctgctc acatgctagc   1440

ggggcccagc agccctgggt ggttttgcca gcatgctaac tcttgtaact cgcagctgca   1500

tcctatgagc tctcccaagc ttccccgccc ctcccctggg tcagccgtga ggcccacctt   1560

tgccaccctc agctctttcc tctggtgtgg cttcagcttg aaagcaacct ggagtcgggg   1620

gcacagcctt tggggcctgg ctgggagagg gtcttggagc attaggggaa gaagagagca   1680

gtgggatctt ggggcctgag aagccttgga acgcttctgg cagcagagct gggtgtggga   1740

atgaggccta gatcgatatc cctgggttag agttgaaatt tgccgcaatt ccactggaag   1800

gcatttccca cgaggccaga ggttgccagg ctgcctgagg tctcctattc tactctgaac   1860

cataaaccca gagaagaatt actcattaac cagcataaat actgcctgag gatcaaaact   1920

cagaggcaaa gagggagttc ctgactgcta gaggtgccac caccacaaac actttttatt   1980

caggagatac tttttgagaa tctctgctct gttcctaggt tcagtgctgg gtcctgggaa   2040

tacagcagga cagacctcag cttatctctt catagaaatt atacaaagag aattggggag   2100

acagctaaga agaaaacaaa gaaataaagc agttacaaat tgtgataagt gctttgaagg   2160

aaagaagggg tctgagacaa caacagggaa ggggcctctc ttgaaacagt agttgggaag   2220

gaggcagaca tgcaccagtg atgtggtgac aggtgctctg aaggaggtca ccaggacctg   2280

acctctttga aggatcagaa aatacttccc tgaaggactg acatttgagc ctagacctga   2340

agggtgagcc atcaagctaa gacaattggg gaagagcatt ccagggagag ggaggagttg   2400

tgcaaaggcc ctggggctcc ttctagctgg aggaatgcaa ggctagcttg tctggagcac   2460

tgagaggatg gcctgaactg agtggagaga gacagaccag gaccaaacca tgcagaggtc   2520

aagggccaca ttcacctttt cagagtgact caatcaaatt tgtagtttgt aaaagtattt   2580

taacagctct gcggcaaagt gcaaatgaaa agtcttgatg gcatggactg gagcggggac   2640

agtggggatg gagaaagggg aatggattgt ggatgtgttt agaaggtaga ttcgatgtga   2700

aggatgaatc tggcttgacc ttctgggtgg ctgatgggcc atttactgag atggggcagc   2760

ctggaagagg aacagaagca gggtcggggt ggagggagaa tactaaactt agcttgagac   2820

attttgcaat aaggaagcta tatctagagt gcttatgtga ctcacctaag gccactcaac   2880

aagtttgtgg cagaactgga ttagaactgc acagaaaaca gccaagctgg gatttgaacc   2940

catgtagtcc aactccaagg cctctgcccc taaccactgt gccataccac ctcccaataa   3000

tcaacagcaa aattataggt ctaacaatgt tttatagaca cccctccatt tatgtgatgg   3060

gtttgcatcc tgataaaccc atcataagtt gaaaatatga tcataagttg aaaatatgat   3120

cataagtcaa aaatgtattt aatataccta acctaccaaa catcatagct tagcctagcc   3180

tgccttaaac atgctcagaa cacttacatt agcctacagt gggcaaaact atccaacaca   3240

aaatctatat tgtaataaag ttgtaaagaa ttttgaataa aaattcaata tttgaagtac   3300

aaaaaaaaaa aaaaaaa                                                  3317


<210>  630
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  630

Met Pro Pro Thr Ser Ser Thr Pro Ser Leu Ser Arg Pro Gly Leu Gly 
1               5                   10                  15


Gln Ala Gly Lys Pro Asp Thr Gly Ser His Pro Pro Pro Thr Ile Ser 
            20                  25                  30


Thr Ser Ile Phe Leu Ser Cys Phe Pro Thr Ile Pro Leu Ser Arg Pro 
        35                  40                  45


Arg Thr Thr Gly Pro Ser His Ser Tyr Gln Ser Ile Ser His Pro Arg 
    50                  55                  60


Ser Cys Arg Asp Val Pro Asp Asp Ile Gln Pro Ile Thr Ser Leu Pro 
65                  70                  75                  80


Gly Val Ala Arg Tyr Gly Val Lys Arg Leu Glu Glu Met Leu Arg Pro 
                85                  90                  95


Leu Val Glu Glu Gly Leu Arg Cys Val Leu Ile Phe Gly Val Pro Ser 
            100                 105                 110


Arg Val Pro Lys Asp Glu Arg Gly Ser Ala Ala Asp Ser Glu Glu Ser 
        115                 120                 125


Pro Ala Ile Glu Ala Ile His Leu Leu Arg Lys Thr Phe Pro Asn Leu 
    130                 135                 140


Leu Val Ala Cys Asp Val Cys Leu Cys Pro Tyr Thr Ser His Gly His 
145                 150                 155                 160


Cys Gly Leu Leu Ser Glu Asn Gly Ala Phe Arg Ala Glu Glu Ser Arg 
                165                 170                 175


Gln Arg Leu Ala Glu Val Ala Leu Ala Tyr Ala Lys Ala Gly Cys Gln 
            180                 185                 190


Val Val Ala Pro Ser Asp Met Met Asp Gly Arg Val Glu Ala Ile Lys 
        195                 200                 205


Glu Ala Leu Met Ala His Gly Leu Gly Asn Arg Val Ser Val Met Ser 
    210                 215                 220


Tyr Ser Ala Lys Phe Ala Ser Cys Phe Tyr Gly Pro Phe Arg Asp Ala 
225                 230                 235                 240


Ala Lys Ser Ser Pro Ala Phe Gly Asp Arg Arg Cys Tyr Gln Leu Pro 
                245                 250                 255


Pro Gly Ala Arg Gly Leu Ala Leu Arg Ala Val Asp Arg Asp Val Arg 
            260                 265                 270


Glu Gly Ala Asp Met Leu Met Val Lys Pro Gly Met Pro Tyr Leu Asp 
        275                 280                 285


Ile Val Arg Glu Val Lys Asp Lys His Pro Asp Leu Pro Leu Ala Val 
    290                 295                 300


Tyr His Val Ser Gly Glu Phe Ala Met Leu Trp His Gly Ala Gln Ala 
305                 310                 315                 320


Gly Ala Phe Asp Leu Lys Ala Ala Val Leu Glu Ala Met Thr Ala Phe 
                325                 330                 335


Arg Arg Ala Gly Ala Asp Ile Ile Ile Thr Tyr Tyr Thr Pro Gln Leu 
            340                 345                 350


Leu Gln Trp Leu Lys Glu Glu 
        355


<210>  631
<211>  2185
<212>  DNA
<213>  Homo sapiens

<400>  631
agcggcgcag ggcaccatgg gaaacggacg gaagctccat tgagccaaat aagttggcca     60

cgtggggcgg aacggaaacc tcgcagggtc agaccgtagc gacgcgggaa gtccggacgc    120

agtagctccc tgaagcggag gcgaagggga gtttaagccc cagcggcggc aatggcggag    180

aggcccgagg acctaaacct gcccaatgcc gtgatcacca ggatcatcaa ggaggcgctc    240

ccggacggtg tcaacatctc caaggaggcc cggagcgcca tctcccgcgc cgccagcgtc    300

ttcgtgctgt acgccacatc ctgtgctaac aactttgcaa tgaaaggaaa gcggaagacg    360

ctgaatgcca gtgatgtgct ctcagccatg gaagagatgg agttccagcg gttcgttatc    420

ccattgaaag aagctctgga agcatatagg cgggagcaga aaggcaagaa ggaggcctca    480

gagcaaaaga agaaggacaa agacaaaaaa acagactcgg aagagcaaga caagagcagg    540

gatgaggaca atgatgaaga cgaagaaagg ctggaagaag aagaacagaa tgaagaggaa    600

gaagtagaca actgaaaagg gcgggagact gtggcacctt ggaaggtacc acttgaaatg    660

agacgtgcta cgtgtttctg tgaagctttt ccatgctggg cagagtagtc tcaggcaaaa    720

gtgcctgaaa agatcagaat aaaaactgac tagaaatacc gtcaaaacca gcacttacca    780

aactcagagc atctgagtag cagaatcctg ttttgcttca tcaatctgaa ggttatggcc    840

ttttgacaag agggattctg aacgactaaa ttagtcagtt tgctcgcttt tgtttactta    900

aatgtatggt tagatggttt ttgatctgca gtcttcccta gtcccccaaa taagtaataa    960

taacttccat gctgcctgct gtgttccaga tcacagaggc agccaaggct caggaaaaac   1020

tggggctttg cttatggtca gcctatgttt gattgcacag tctttgacaa tagtagctta   1080

ctaagactgc tcagaatgag taagctttag gaaactacta aaatgctgtg ggagaataac   1140

aaaatccgtt ctctctcttc acttgacaga agcattaact gaattttgtt tttcatagac   1200

ccacttggcc caaaaccttt ctatattgcc tgtagatgat cggcctgctg gtgtggtagt   1260

aatctgatca cagatattct taaatcagca gtgtggaatg gtattagtca aacatggtgc   1320

cagtgtcttt tacaaaaaca gatggcatag tgtcagatgt accttactct ctgctactgt   1380

acagctttag gatttgtcat cacctcccgg aaggtgtaaa accccaggct tcctcttctt   1440

gtagtccatc tcccagactt gtgactatgg cttttcattc ttcaattcat gacgagtgcc   1500

aaacttgatt ttctctaggc acagctttct ccctctgtgc ctcctgcttc ctttctctct   1560

cctgcctctc ctctgctccc catcccactt tctcatctgc ctccttttct cacttctgtc   1620

agtctgtaag ctttgataac ctgcttaata ctccaaagtg tgagttcctc tgatctcttg   1680

attccttagt tctaatctca cgttttgttt ttaagagatg gagtctctca ctctgtggcc   1740

caggctggag tgcagtggca tgatcatagc tcattgcatc cttgaaatcc tgggctcagg   1800

tgatcctccc gcctgagcct cctgagtatc tgggactaca gatgcgtgcc accaagcctg   1860

gctaattttg tctcatgtct tctaaaaatt attttgtgaa gccccttcac aaaaaacctt   1920

aagggaaatc tgatggtgct caggaatcta actctcccta aaccatcctc tttaactgct   1980

tctaaaatat ctctgttggc ctttcttagc ctttttctgt ttccattcag tgctccaagc   2040

gctttttgtt tctaagttga gtgcttgggg tttgacaggt agtgacgtgt agtttgacac   2100

tgttaacttg ttaaatacag tgaaaagttt gtgagtgaag aatgctgaga agattgtaat   2160

gctttgtaca aataaaagtc ttgtt                                         2185


<210>  632
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  632

Met Ala Glu Arg Pro Glu Asp Leu Asn Leu Pro Asn Ala Val Ile Thr 
1               5                   10                  15


Arg Ile Ile Lys Glu Ala Leu Pro Asp Gly Val Asn Ile Ser Lys Glu 
            20                  25                  30


Ala Arg Ser Ala Ile Ser Arg Ala Ala Ser Val Phe Val Leu Tyr Ala 
        35                  40                  45


Thr Ser Cys Ala Asn Asn Phe Ala Met Lys Gly Lys Arg Lys Thr Leu 
    50                  55                  60


Asn Ala Ser Asp Val Leu Ser Ala Met Glu Glu Met Glu Phe Gln Arg 
65                  70                  75                  80


Phe Val Ile Pro Leu Lys Glu Ala Leu Glu Ala Tyr Arg Arg Glu Gln 
                85                  90                  95


Lys Gly Lys Lys Glu Ala Ser Glu Gln Lys Lys Lys Asp Lys Asp Lys 
            100                 105                 110


Lys Thr Asp Ser Glu Glu Gln Asp Lys Ser Arg Asp Glu Asp Asn Asp 
        115                 120                 125


Glu Asp Glu Glu Arg Leu Glu Glu Glu Glu Gln Asn Glu Glu Glu Glu 
    130                 135                 140


Val Asp Asn 
145


<210>  633
<211>  2099
<212>  DNA
<213>  Homo sapiens

<400>  633
cctttaggac ccgaggcagg ctctgggccc gccgggtccg ttaatctcac cgcgccgcaa     60

ggggccacgt tttaccactt gatttagcaa ccctaagcgg tttggaatct gctttgctct    120

cacaggacct cagcccgtcg tgatcagatt ctcccacttt cttttttctt tcctggaatg    180

gagtgggcag tctttttcca tctctaccga agttgatgtt catttttaat cttttcgccc    240

ctcacgcttt tgtaataatg gtactaagac tgagtgttat ttagatttta ttgttgttgt    300

ttgtgtttaa cgcgaactat ttaggcagcc cagggataat gctggccata tagagatgcg    360

cctgattagg tctcaggagt caattcggac tgggcagagc actagaatgc tgcagggttg    420

gcctttggcc taaaccattt ctagctatgg acttgccaga tgagagccag tgggacgaaa    480

ccacctgtgg cttggctgtt tgtcagcacc cacaatgctg ggcaactatc cgccgcattg    540

agaggggcca tcctcgaatc ctcggctcat cctgcaaaac tcccctggat gctgaagata    600

aactcccagt gctcaccgtg gtagacatct tagattccgg ctttgcagct catcatttac    660

cagaatgtac ctttactaag gcccattctt tattgtctca gagttcaaag ttttactcca    720

aatttcatgg caggcctccg aagggtttac ctgacaaaag tttgatcaac tgtactaaca    780

gacttcccaa atttccagtg ttgaatttga atgagacgca acttccctgc cctgaagatg    840

ttagaaatat ggttgtattg tggatcccag aagaaacaga gatacatgtg agccagcatg    900

ggaagaagaa aagaaagaac tcggcagtga aaagcaagtc atttctgggt ctctctggaa    960

atcagtccgc aggaacacga gtaggaacac cagggatgat cgtgcctccc ccaaccccag   1020

tgcaattgtc tgaacaattc agttcagatt tcctacctct ctgggctcaa tccgaagcgt   1080

tacctcagga tctactgaag gaacttttgc caggtggaaa gcaaaccatg ctctgtccag   1140

agatgaagat aaaattggcc atgatgaaaa agaatcttcc cttggaaaag aaccgacctg   1200

acagtgtgat ttcttctaag atgtttctat ctatacaccg cctcaccctg gaaagaccag   1260

cactgcgata tcctgaacgt ttgaagaaat tacataacct gaagacagaa ggttacagga   1320

aacagcagca gcggcagcag cagcagcagc agcaacagaa gaaggtgaaa acacctatta   1380

agaaacagga ggctaaaaag aaagccaaga gtgatccagg gatccagagc acttcacata   1440

aacatccagt taccaccgtt catgaccgtc tctatggtta cagaactctg ccaggtcaga   1500

acagtgacat gaagcagcag cagcagatgg aaaaaggaac cacttcgaaa caggattcca   1560

cggagagacc aaagatgaac tactatgacc atgcggattt ccaccacagt gtaaaaagtc   1620

ctgaattgta tgaaacagaa cccactaaca aggacattag tgctccagtg gacgctgtgc   1680

cagaagccca ggctgccagg caaaagaaga tctcctttaa cttttcagaa attatggcta   1740

gcacaggctg gaactctgag ctcaaactac ttaggattct tcaggacact gatgatgagg   1800

atgaggagga ccagtcctct ggggcagagt gagaagcctc tggaggaata gactgaaggc   1860

atcccctggg gcagccgtgt tccaaagcgg gatggctggt atcctgaggg cagcaacgtt   1920

tcacataagg gcaagaggag aggggcttct gctctctgga gcctttacca gggcctgagc   1980

tctgagctta gggattccat tttctttgtt cacctctact tgcctctaaa ataaatgtag   2040

gagaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa    2099


<210>  634
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  634

Met Asp Leu Pro Asp Glu Ser Gln Trp Asp Glu Thr Thr Cys Gly Leu 
1               5                   10                  15


Ala Val Cys Gln His Pro Gln Cys Trp Ala Thr Ile Arg Arg Ile Glu 
            20                  25                  30


Arg Gly His Pro Arg Ile Leu Gly Ser Ser Cys Lys Thr Pro Leu Asp 
        35                  40                  45


Ala Glu Asp Lys Leu Pro Val Leu Thr Val Val Asp Ile Leu Asp Ser 
    50                  55                  60


Gly Phe Ala Ala His His Leu Pro Glu Cys Thr Phe Thr Lys Ala His 
65                  70                  75                  80


Ser Leu Leu Ser Gln Ser Ser Lys Phe Tyr Ser Lys Phe His Gly Arg 
                85                  90                  95


Pro Pro Lys Gly Leu Pro Asp Lys Ser Leu Ile Asn Cys Thr Asn Arg 
            100                 105                 110


Leu Pro Lys Phe Pro Val Leu Asn Leu Asn Glu Thr Gln Leu Pro Cys 
        115                 120                 125


Pro Glu Asp Val Arg Asn Met Val Val Leu Trp Ile Pro Glu Glu Thr 
    130                 135                 140


Glu Ile His Val Ser Gln His Gly Lys Lys Lys Arg Lys Asn Ser Ala 
145                 150                 155                 160


Val Lys Ser Lys Ser Phe Leu Gly Leu Ser Gly Asn Gln Ser Ala Gly 
                165                 170                 175


Thr Arg Val Gly Thr Pro Gly Met Ile Val Pro Pro Pro Thr Pro Val 
            180                 185                 190


Gln Leu Ser Glu Gln Phe Ser Ser Asp Phe Leu Pro Leu Trp Ala Gln 
        195                 200                 205


Ser Glu Ala Leu Pro Gln Asp Leu Leu Lys Glu Leu Leu Pro Gly Gly 
    210                 215                 220


Lys Gln Thr Met Leu Cys Pro Glu Met Lys Ile Lys Leu Ala Met Met 
225                 230                 235                 240


Lys Lys Asn Leu Pro Leu Glu Lys Asn Arg Pro Asp Ser Val Ile Ser 
                245                 250                 255


Ser Lys Met Phe Leu Ser Ile His Arg Leu Thr Leu Glu Arg Pro Ala 
            260                 265                 270


Leu Arg Tyr Pro Glu Arg Leu Lys Lys Leu His Asn Leu Lys Thr Glu 
        275                 280                 285


Gly Tyr Arg Lys Gln Gln Gln Arg Gln Gln Gln Gln Gln Gln Gln Gln 
    290                 295                 300


Lys Lys Val Lys Thr Pro Ile Lys Lys Gln Glu Ala Lys Lys Lys Ala 
305                 310                 315                 320


Lys Ser Asp Pro Gly Ile Gln Ser Thr Ser His Lys His Pro Val Thr 
                325                 330                 335


Thr Val His Asp Arg Leu Tyr Gly Tyr Arg Thr Leu Pro Gly Gln Asn 
            340                 345                 350


Ser Asp Met Lys Gln Gln Gln Gln Met Glu Lys Gly Thr Thr Ser Lys 
        355                 360                 365


Gln Asp Ser Thr Glu Arg Pro Lys Met Asn Tyr Tyr Asp His Ala Asp 
    370                 375                 380


Phe His His Ser Val Lys Ser Pro Glu Leu Tyr Glu Thr Glu Pro Thr 
385                 390                 395                 400


Asn Lys Asp Ile Ser Ala Pro Val Asp Ala Val Pro Glu Ala Gln Ala 
                405                 410                 415


Ala Arg Gln Lys Lys Ile Ser Phe Asn Phe Ser Glu Ile Met Ala Ser 
            420                 425                 430


Thr Gly Trp Asn Ser Glu Leu Lys Leu Leu Arg Ile Leu Gln Asp Thr 
        435                 440                 445


Asp Asp Glu Asp Glu Glu Asp Gln Ser Ser Gly Ala Glu 
    450                 455                 460


<210>  635
<211>  2564
<212>  DNA
<213>  Homo sapiens

<400>  635
agactccggt tactggggag caacacagcc gcctcgggtt gcagacgctc ctgtccgggt     60

cgcagtggga cgccatggag cgctccctgc accgcgtctc cctcgggagc cggcgtgccc    120

acccggactt gtccttctac ctcaccacct ttggtcagct gaggctgtcc attgatgccc    180

aggaccgggt tctgctgctt cacattatag aaggtaaagg cctgatcagc aaacagcctg    240

gcacctgtga tccgtatgtg aagatttctt tgatccctga agatagtaga ctacgccacc    300

agaagacgca gaccgttcca gactgcagag acccggcttt ccacgagcac ttcttctttc    360

ctgtccaaga ggaggatgat cagaagcgtc tcttggttac tgtgtggaac agggccagcc    420

agtccagaca gagtggactc attggctgca tgagctttgg ggtgaagtct ctcctgactc    480

cagacaagga gatcagtggt tggtactacc tcctagggga gcacctgggc cggaccaagc    540

acttgaaggt ggccaggcgg cgactgcggc cgctgagaga cccgctgctg agaatgccag    600

gaggtgggga cactgagaat gggaagaaac taaagatcac catcccgagg ggaaaggacg    660

gctttggctt caccatctgc tgcgactctc cagttcgagt ccaggccgtg gattccgggg    720

gtccggcgga acgggcaggg ctgcagcagc tggacacggt gctgcagctg aatgagaggc    780

ctgtggagca ctggaaatgt gtggagctgg cccacgagat ccggagctgc cccagtgaga    840

tcatcctact cgtgtggcgc atggtccccc aggtcaagcc aggaccagat ggcggggtcc    900

tgcggcgggc ctcctgcaag tcgacacatg acctccagtc accccccaac aaacgggaga    960

agaactgcac ccatggggtc caggcacggc ctgagcagcg ccacagctgc cacctggtat   1020

gtgacagctc tgatgggctg ctgctcggcg gctgggagcg ctacaccgag gtggccaagc   1080

gcgggggcca gcacaccctg cctgcactgt cccgtgccac tgcccccacc gaccccaact   1140

acatcatcct ggccccgctg aatcctggga gccagctgct ccggcctgtg taccaggagg   1200

ataccatccc cgaagaatca gggagtccca gtaaagggaa gtcctacaca ggcctgggga   1260

agaagtcccg gctgatgaag acagtgcaga ccatgaaggg ccacgggaac taccaaaact   1320

gcccggttgt gaggccgcat gccacgcact caagctatgg cacctacgtc accctggccc   1380

ccaaagtcct ggtgttccct gtctttgttc agcctctaga tctctgtaat cctgcccgga   1440

ccctcctgct gtcagaggag ctgctgctgt atgaagggag gaacaaggct gccgaggtga   1500

cactgtttgc ctattcggac ctgctgctct tcaccaagga ggacgagcct ggccgctgcg   1560

acgtcctgag gaaccccctc tacctccaga gtgtgaagct gcaggaaggt tcttcagaag   1620

acctgaaatt ctgcgtgctc tatctagcag agaaggcaga gtgcttattc actttggaag   1680

cgcactcgca ggagcagaag aagagagtgt gctggtgcct gtcggagaac atcgccaagc   1740

agcaacagct ggcagcatca cccccggaca gcaagaaact ccaccctttc ggctctctcc   1800

agcaggagat ggggccggtc aactcaacca atgccaccca ggatagaagc tttacctcac   1860

caggacagac tctgattggc tgagcaaacc caagggcggg actctgcttc tggcaactta   1920

accctttctt gggcatcccc taccacacag taacctcacc tcaactggac ctgaaacaga   1980

ggaccaagat ggtgggtcta gggtcatctg aagggagtgg tcccaagggt gcatgtggat   2040

gtcaacagaa ggaccacaat ggtgtgagag gccttgtggg catgcagaga ctggcagcag   2100

aaagtcccaa gaggagagga ctcagaggct tcttccttcc aaggaggagg aggaggagga   2160

cattccacat ctgggcttcc agtggtggct cccggacctg ccttgggggc agcaggagag   2220

gttgggagag gtcaccctga tgaagaacaa tgccatgatc tgctgctgcc agaggacatc   2280

tccgcccatc cactcatttt ccacctgtac acattggctc attcattcga tggatatttc   2340

gggtgcatct actttatgcc aggctctatg ctaggagctg gggatactgt ggagaaaaag   2400

tcggatatgg tctcgctctc atcaagattt cagtctagct gggagtgagc gttaaataag   2460

tcaataccaa cacacacacg tgcacacacg tgatggcaag ctgtgatcat ctatgaaaga   2520

aaaaacacag atttctttaa gagggaaaaa aaaaaaaaaa aaaa                    2564


<210>  636
<211>  602
<212>  PRT
<213>  Homo sapiens

<400>  636

Met Glu Arg Ser Leu His Arg Val Ser Leu Gly Ser Arg Arg Ala His 
1               5                   10                  15


Pro Asp Leu Ser Phe Tyr Leu Thr Thr Phe Gly Gln Leu Arg Leu Ser 
            20                  25                  30


Ile Asp Ala Gln Asp Arg Val Leu Leu Leu His Ile Ile Glu Gly Lys 
        35                  40                  45


Gly Leu Ile Ser Lys Gln Pro Gly Thr Cys Asp Pro Tyr Val Lys Ile 
    50                  55                  60


Ser Leu Ile Pro Glu Asp Ser Arg Leu Arg His Gln Lys Thr Gln Thr 
65                  70                  75                  80


Val Pro Asp Cys Arg Asp Pro Ala Phe His Glu His Phe Phe Phe Pro 
                85                  90                  95


Val Gln Glu Glu Asp Asp Gln Lys Arg Leu Leu Val Thr Val Trp Asn 
            100                 105                 110


Arg Ala Ser Gln Ser Arg Gln Ser Gly Leu Ile Gly Cys Met Ser Phe 
        115                 120                 125


Gly Val Lys Ser Leu Leu Thr Pro Asp Lys Glu Ile Ser Gly Trp Tyr 
    130                 135                 140


Tyr Leu Leu Gly Glu His Leu Gly Arg Thr Lys His Leu Lys Val Ala 
145                 150                 155                 160


Arg Arg Arg Leu Arg Pro Leu Arg Asp Pro Leu Leu Arg Met Pro Gly 
                165                 170                 175


Gly Gly Asp Thr Glu Asn Gly Lys Lys Leu Lys Ile Thr Ile Pro Arg 
            180                 185                 190


Gly Lys Asp Gly Phe Gly Phe Thr Ile Cys Cys Asp Ser Pro Val Arg 
        195                 200                 205


Val Gln Ala Val Asp Ser Gly Gly Pro Ala Glu Arg Ala Gly Leu Gln 
    210                 215                 220


Gln Leu Asp Thr Val Leu Gln Leu Asn Glu Arg Pro Val Glu His Trp 
225                 230                 235                 240


Lys Cys Val Glu Leu Ala His Glu Ile Arg Ser Cys Pro Ser Glu Ile 
                245                 250                 255


Ile Leu Leu Val Trp Arg Met Val Pro Gln Val Lys Pro Gly Pro Asp 
            260                 265                 270


Gly Gly Val Leu Arg Arg Ala Ser Cys Lys Ser Thr His Asp Leu Gln 
        275                 280                 285


Ser Pro Pro Asn Lys Arg Glu Lys Asn Cys Thr His Gly Val Gln Ala 
    290                 295                 300


Arg Pro Glu Gln Arg His Ser Cys His Leu Val Cys Asp Ser Ser Asp 
305                 310                 315                 320


Gly Leu Leu Leu Gly Gly Trp Glu Arg Tyr Thr Glu Val Ala Lys Arg 
                325                 330                 335


Gly Gly Gln His Thr Leu Pro Ala Leu Ser Arg Ala Thr Ala Pro Thr 
            340                 345                 350


Asp Pro Asn Tyr Ile Ile Leu Ala Pro Leu Asn Pro Gly Ser Gln Leu 
        355                 360                 365


Leu Arg Pro Val Tyr Gln Glu Asp Thr Ile Pro Glu Glu Ser Gly Ser 
    370                 375                 380


Pro Ser Lys Gly Lys Ser Tyr Thr Gly Leu Gly Lys Lys Ser Arg Leu 
385                 390                 395                 400


Met Lys Thr Val Gln Thr Met Lys Gly His Gly Asn Tyr Gln Asn Cys 
                405                 410                 415


Pro Val Val Arg Pro His Ala Thr His Ser Ser Tyr Gly Thr Tyr Val 
            420                 425                 430


Thr Leu Ala Pro Lys Val Leu Val Phe Pro Val Phe Val Gln Pro Leu 
        435                 440                 445


Asp Leu Cys Asn Pro Ala Arg Thr Leu Leu Leu Ser Glu Glu Leu Leu 
    450                 455                 460


Leu Tyr Glu Gly Arg Asn Lys Ala Ala Glu Val Thr Leu Phe Ala Tyr 
465                 470                 475                 480


Ser Asp Leu Leu Leu Phe Thr Lys Glu Asp Glu Pro Gly Arg Cys Asp 
                485                 490                 495


Val Leu Arg Asn Pro Leu Tyr Leu Gln Ser Val Lys Leu Gln Glu Gly 
            500                 505                 510


Ser Ser Glu Asp Leu Lys Phe Cys Val Leu Tyr Leu Ala Glu Lys Ala 
        515                 520                 525


Glu Cys Leu Phe Thr Leu Glu Ala His Ser Gln Glu Gln Lys Lys Arg 
    530                 535                 540


Val Cys Trp Cys Leu Ser Glu Asn Ile Ala Lys Gln Gln Gln Leu Ala 
545                 550                 555                 560


Ala Ser Pro Pro Asp Ser Lys Lys Leu His Pro Phe Gly Ser Leu Gln 
                565                 570                 575


Gln Glu Met Gly Pro Val Asn Ser Thr Asn Ala Thr Gln Asp Arg Ser 
            580                 585                 590


Phe Thr Ser Pro Gly Gln Thr Leu Ile Gly 
        595                 600


<210>  637
<211>  2914
<212>  DNA
<213>  Homo sapiens

<400>  637
ttctcggctg atctctctgg gtaggtgccc tctgggggca gtacccctgc ctgagtggca     60

cttcccctcc tggctttgtt tggtttggcc tcgatttaga acagggttgg cagaggcagg    120

ctgacttgca tttctggttt tgggtttgtt gctgcacttt ccccaagggg tgggcgggct    180

ctgactgaca gtcaccactg ggacaggcct gggccccacc ctcaccaccc aggaaagggg    240

aaatgcggcc cgctccccac tcagtgccac tctgtgccac tccgtgccag gccctgaggg    300

cacccggttg ctgcttcctt ccgtctttcc ccaaggacta tcagagatgc cagcgtgacc    360

cctgacacgt gtgtgcagca gcctgcagct gccccaagcc atggctgaac actgactccc    420

agctgtgggg cttcaccatt acagactccc cagggcttca aagacttctc agcttcgagc    480

atggcttttg gctgtcaggg cagctgtaca atagtggatg tttgagacgg aggcagatga    540

gaagagggag atggccttgg aggaagggaa ggggcctggt gccgaggatt ccccacccag    600

caaggagccc tctcctggcc aggagcttcc tccaggacaa gaccttccac ccaacaagga    660

ctccccttct gggcaggaac ccgctcccag ccaagaacca ctgtccagca aagactcagc    720

tacctctgaa ggatcccctc caggcccaga tgctccgccc agcaaggatg tgccaccatg    780

ccaggaaccc cctccagccc aagacctctc accctgccag gacctacctg ctggtcaaga    840

acccctgcct caccaggacc ctctactcac caaagacctc cctgccatcc aggaatcccc    900

cacccgggac cttccaccct gtcaagatct gcctcctagc caggtctccc tgccagccaa    960

ggcccttact gaggacacca tgagctccgg ggacctacta gcagctactg gggacccacc   1020

tgcggccccc aggccagcct tcgtgatccc tgaggtccgg ctggatagca cctacagcca   1080

gaaggcaggg gcagagcagg gctgctcggg agatgaggag gatgcagaag aggccgagga   1140

ggtggaggag ggggaggaag gggaggagga cgaggatgag gacaccagcg atgacaacta   1200

cggagagcgc agtgaggcca agcgcagcag catgatcgag acgggccagg gggctgaggg   1260

tggcctctca ctgcgtgtgc agaactcgct gcggcgccgg acgcacagcg agggcagcct   1320

gctgcaggag ccccgagggc cctgctttgc ctccgacacc accttgcact gctcagacgg   1380

tgagggcgcc gcctccacct ggggcatgcc ttcgcccagc accctcaaga aagagctggg   1440

ccgcaatggt ggctccatgc accacctttc cctcttcttc acaggacaca ggaagatgag   1500

cggggctgac accgttgggg atgatgacga agcctcccgg aagagaaaga gcaaaaacct   1560

agccaaggac atgaagaaca agctggggat cttcagacgg cggaatgagt cccctggagc   1620

ccctcccgcg ggcaaggcag acaaaatgat gaagtcattc aagcccacct cagaggaagc   1680

cctcaagtgg ggcgagtcct tggagaagct gctggttcac aaatacgggt tagcagtgtt   1740

ccaagccttc cttcgcactg agttcagtga ggagaatctg gagttctggt tggcttgtga   1800

ggacttcaag aaggtcaagt cacagtccaa gatggcatcc aaggccaaga agatctttgc   1860

tgaatacatc gcgatccagg catgcaagga ggtcaacctg gactcctaca cgcgggagca   1920

caccaaggac aacctgcaga gcgtcacgcg gggctgcttc gacctggcac agaagcgcat   1980

cttcgggctc atggaaaagg actcgtaccc tcgctttctc cgttctgacc tctacctgga   2040

ccttattaac cagaagaaga tgagtccccc gctttagggg ccactggagt cgagctcagc   2100

gttcacacca ggcgggctgg gtcccctgcc cacctgcctc cctgccccct gtgacggagg   2160

gggcaagcaa gcccccagag gctgtgtctc tggacagacg gatagacata cggaagcgag   2220

gcctggacca agagaggccc aggctactgg aggagtagaa ggatgggccc cgtggggtcc   2280

ccactgcccc ggtacgaggg ggcccaagac cctggcaggt caggggccct ggccaagcca   2340

gatctggagc tgctgctccc tgctgcggag accgcggagg cttcgcgttg accaagttcc   2400

ttaaagaact ggctgatggg gcaggaggtc caggcctggg ctctcgggcc ctcctagagg   2460

gccattggag cttgcagctc agacccccac tttgagtttt atttatttaa atagtagttg   2520

gatgcttggc acgtcgtcct gtaataggaa acccttgcct catcagtttt cctgatttac   2580

aagtgcaata ttttagccaa tgccttggga gaagctgcca tgcaaaggtg gacaccattc   2640

tccagcttca ggggatatgc tcgtcccggg caccggtggc aggcagctgg ccttctggac   2700

taaggcagcc tggggggaca ctgcagtctg gctacacaca gagatctggc accccctggg   2760

tggagtgtcc ctcgggggct ttgggaaagc atggcaccct cagaccacac agtagccaag   2820

ttctggagca aataaaaggc ctgtgttatt tcttgttctt gaaaaaaaaa aaaaaaaaaa   2880

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                               2914


<210>  638
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  638

Met Phe Glu Thr Glu Ala Asp Glu Lys Arg Glu Met Ala Leu Glu Glu 
1               5                   10                  15


Gly Lys Gly Pro Gly Ala Glu Asp Ser Pro Pro Ser Lys Glu Pro Ser 
            20                  25                  30


Pro Gly Gln Glu Leu Pro Pro Gly Gln Asp Leu Pro Pro Asn Lys Asp 
        35                  40                  45


Ser Pro Ser Gly Gln Glu Pro Ala Pro Ser Gln Glu Pro Leu Ser Ser 
    50                  55                  60


Lys Asp Ser Ala Thr Ser Glu Gly Ser Pro Pro Gly Pro Asp Ala Pro 
65                  70                  75                  80


Pro Ser Lys Asp Val Pro Pro Cys Gln Glu Pro Pro Pro Ala Gln Asp 
                85                  90                  95


Leu Ser Pro Cys Gln Asp Leu Pro Ala Gly Gln Glu Pro Leu Pro His 
            100                 105                 110


Gln Asp Pro Leu Leu Thr Lys Asp Leu Pro Ala Ile Gln Glu Ser Pro 
        115                 120                 125


Thr Arg Asp Leu Pro Pro Cys Gln Asp Leu Pro Pro Ser Gln Val Ser 
    130                 135                 140


Leu Pro Ala Lys Ala Leu Thr Glu Asp Thr Met Ser Ser Gly Asp Leu 
145                 150                 155                 160


Leu Ala Ala Thr Gly Asp Pro Pro Ala Ala Pro Arg Pro Ala Phe Val 
                165                 170                 175


Ile Pro Glu Val Arg Leu Asp Ser Thr Tyr Ser Gln Lys Ala Gly Ala 
            180                 185                 190


Glu Gln Gly Cys Ser Gly Asp Glu Glu Asp Ala Glu Glu Ala Glu Glu 
        195                 200                 205


Val Glu Glu Gly Glu Glu Gly Glu Glu Asp Glu Asp Glu Asp Thr Ser 
    210                 215                 220


Asp Asp Asn Tyr Gly Glu Arg Ser Glu Ala Lys Arg Ser Ser Met Ile 
225                 230                 235                 240


Glu Thr Gly Gln Gly Ala Glu Gly Gly Leu Ser Leu Arg Val Gln Asn 
                245                 250                 255


Ser Leu Arg Arg Arg Thr His Ser Glu Gly Ser Leu Leu Gln Glu Pro 
            260                 265                 270


Arg Gly Pro Cys Phe Ala Ser Asp Thr Thr Leu His Cys Ser Asp Gly 
        275                 280                 285


Glu Gly Ala Ala Ser Thr Trp Gly Met Pro Ser Pro Ser Thr Leu Lys 
    290                 295                 300


Lys Glu Leu Gly Arg Asn Gly Gly Ser Met His His Leu Ser Leu Phe 
305                 310                 315                 320


Phe Thr Gly His Arg Lys Met Ser Gly Ala Asp Thr Val Gly Asp Asp 
                325                 330                 335


Asp Glu Ala Ser Arg Lys Arg Lys Ser Lys Asn Leu Ala Lys Asp Met 
            340                 345                 350


Lys Asn Lys Leu Gly Ile Phe Arg Arg Arg Asn Glu Ser Pro Gly Ala 
        355                 360                 365


Pro Pro Ala Gly Lys Ala Asp Lys Met Met Lys Ser Phe Lys Pro Thr 
    370                 375                 380


Ser Glu Glu Ala Leu Lys Trp Gly Glu Ser Leu Glu Lys Leu Leu Val 
385                 390                 395                 400


His Lys Tyr Gly Leu Ala Val Phe Gln Ala Phe Leu Arg Thr Glu Phe 
                405                 410                 415


Ser Glu Glu Asn Leu Glu Phe Trp Leu Ala Cys Glu Asp Phe Lys Lys 
            420                 425                 430


Val Lys Ser Gln Ser Lys Met Ala Ser Lys Ala Lys Lys Ile Phe Ala 
        435                 440                 445


Glu Tyr Ile Ala Ile Gln Ala Cys Lys Glu Val Asn Leu Asp Ser Tyr 
    450                 455                 460


Thr Arg Glu His Thr Lys Asp Asn Leu Gln Ser Val Thr Arg Gly Cys 
465                 470                 475                 480


Phe Asp Leu Ala Gln Lys Arg Ile Phe Gly Leu Met Glu Lys Asp Ser 
                485                 490                 495


Tyr Pro Arg Phe Leu Arg Ser Asp Leu Tyr Leu Asp Leu Ile Asn Gln 
            500                 505                 510


Lys Lys Met Ser Pro Pro Leu 
        515


<210>  639
<211>  3741
<212>  DNA
<213>  Homo sapiens

<400>  639
ttggggaggt gagaggtgat ttcctgccat tcttctgtgg ggcgggcttc ccagggtgct     60

catgccaggc tgacgggtcc agtgcgggct cccgctgctg ggggagagct gggttttcat    120

ggggcggcag ccgaggcagg acccgcagcc atgaaccgct tcaatgggct ctgcaaggtg    180

tgctcggagc gccgctaccg ccagatcacc atcccgaggg gaaaggacgg ctttggcttc    240

accatctgct gcgactctcc agttcgagtc caggccgtgg attccggggg tccggcggaa    300

cgggcagggc tgcagcagct ggacacggtg ctgcagctga atgagaggcc tgtggagcac    360

tggaaatgtg tggagctggc ccacgagatc cggagctgcc ccagtgagat catcctactc    420

gtgtggcgca tggtccccca ggtcaagcca ggaccagatg gcggggtcct gcggcgggcc    480

tcctgcaagt cgacacatga cctccagtca ccccccaaca aacgggagaa gaactgcacc    540

catggggtcc aggcacggcc tgagcagcgc cacagctgcc acctggtatg tgacagctct    600

gatgggctgc tgctcggcgg ctgggagcgc tacaccgagg tggccaagcg cgggggccag    660

cacaccctgc ctgcactgtc ccgtgccact gcccccaccg accccaacta catcatcctg    720

gccccgctga atcctgggag ccagctgctc cggcctgtgt accaggagga taccatcccc    780

gaagaatcag ggagtcccag taaagggaag tcctacacag gcctggggaa gaagtcccgg    840

ctgatgaaga cagtgcagac catgaagggc cacgggaact accaaaactg cccggttgtg    900

aggccgcatg ccacgcactc aagctatggc acctacgtca ccctggcccc caaagtcctg    960

gtgttccctg tctttgttca gcctctagat ctctgtaatc ctgcccggac cctcctgctg   1020

tcagaggagc tgctgctgta tgaagggagg aacaaggctg ccgaggtgac actgtttgcc   1080

tattcggacc tgctgctctt caccaaggag gacgagcctg gccgctgcga cgtcctgagg   1140

aaccccctct acctccagag tgtgaagctg caggaaggtt cttcagaaga cctgaaattc   1200

tgcgtgctct atctagcaga gaaggcagag tgcttattca ctttggaagc gcactcgcag   1260

gagcagaaga agagagtgtg ctggtgcctg tcggagaaca tcgccaagca gcaacagctg   1320

gcagcatcac ccccggacag caagatgttt gagacggagg cagatgagaa gagggagatg   1380

gccttggagg aagggaaggg gcctggtgcc gaggattccc cacccagcaa ggagccctct   1440

cctggccagg agcttcctcc aggacaagac cttccaccca acaaggactc cccttctggg   1500

caggaacccg ctcccagcca agaaccactg tccagcaaag actcagctac ctctgaagga   1560

tcccctccag gcccagatgc tccgcccagc aaggatgtgc caccatgcca ggaaccccct   1620

ccagcccaag acctctcacc ctgccaggac ctacctgctg gtcaagaacc cctgcctcac   1680

caggaccctc tactcaccaa agacctccct gccatccagg aatcccccac ccgggacctt   1740

ccaccctgtc aagatctgcc tcctagccag gtctccctgc cagccaaggc ccttactgag   1800

gacaccatga gctccgggga cctactagca gctactgggg acccacctgc ggcccccagg   1860

ccagccttcg tgatccctga ggtccggctg gatagcacct acagccagaa ggcaggggca   1920

gagcagggct gctcgggaga tgaggaggat gcagaagagg ccgaggaggt ggaggagggg   1980

gaggaagggg aggaggacga ggatgaggac accagcgatg acaactacgg agagcgcagt   2040

gaggccaagc gcagcagcat gatcgagacg ggccaggggg ctgagggtgg cctctcactg   2100

cgtgtgcaga actcgctgcg gcgccggacg cacagcgagg gcagcctgct gcaggagccc   2160

cgagggccct gctttgcctc cgacaccacc ttgcactgct cagacggtga gggcgccgcc   2220

tccacctggg gcatgccttc gcccagcacc ctcaagaaag agctgggccg caatggtggc   2280

tccatgcacc acctttccct cttcttcaca ggacacagga agatgagcgg ggctgacacc   2340

gttggggatg atgacgaagc ctcccggaag agaaagagca aaaacctagc caaggacatg   2400

aagaacaagc tggggatctt cagacggcgg aatgagtccc ctggagcccc tcccgcgggc   2460

aaggcagaca aaatgatgaa gtcattcaag cccacctcag aggaagccct caagtggggc   2520

gagtccttgg agaagctgct ggttcacaaa tacgggttag cagtgttcca agccttcctt   2580

cgcactgagt tcagtgagga gaatctggag ttctggttgg cttgtgagga cttcaagaag   2640

gtcaagtcac agtccaagat ggcatccaag gccaagaaga tctttgctga atacatcgcg   2700

atccaggcat gcaaggaggt caacctggac tcctacacgc gggagcacac caaggacaac   2760

ctgcagagcg tcacgcgggg ctgcttcgac ctggcacaga agcgcatctt cgggctcatg   2820

gaaaaggact cgtaccctcg ctttctccgt tctgacctct acctggacct tattaaccag   2880

aagaagatga gtcccccgct ttaggggcca ctggagtcga gctcagcgtt cacaccaggc   2940

gggctgggtc ccctgcccac ctgcctccct gccccctgtg acggaggggg caagcaagcc   3000

cccagaggct gtgtctctgg acagacggat agacatacgg aagcgaggcc tggaccaaga   3060

gaggcccagg ctactggagg agtagaagga tgggccccgt ggggtcccca ctgccccggt   3120

acgagggggc ccaagaccct ggcaggtcag gggccctggc caagccagat ctggagctgc   3180

tgctccctgc tgcggagacc gcggaggctt cgcgttgacc aagttcctta aagaactggc   3240

tgatggggca ggaggtccag gcctgggctc tcgggccctc ctagagggcc attggagctt   3300

gcagctcaga cccccacttt gagttttatt tatttaaata gtagttggat gcttggcacg   3360

tcgtcctgta ataggaaacc cttgcctcat cagttttcct gatttacaag tgcaatattt   3420

tagccaatgc cttgggagaa gctgccatgc aaaggtggac accattctcc agcttcaggg   3480

gatatgctcg tcccgggcac cggtggcagg cagctggcct tctggactaa ggcagcctgg   3540

ggggacactg cagtctggct acacacagag atctggcacc ccctgggtgg agtgtccctc   3600

gggggctttg ggaaagcatg gcaccctcag accacacagt agccaagttc tggagcaaat   3660

aaaaggcctg tgttatttct tgttcttgaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3720

aaaaaaaaaa aaaaaaaaaa a                                             3741


<210>  640
<211>  917
<212>  PRT
<213>  Homo sapiens

<400>  640

Met Asn Arg Phe Asn Gly Leu Cys Lys Val Cys Ser Glu Arg Arg Tyr 
1               5                   10                  15


Arg Gln Ile Thr Ile Pro Arg Gly Lys Asp Gly Phe Gly Phe Thr Ile 
            20                  25                  30


Cys Cys Asp Ser Pro Val Arg Val Gln Ala Val Asp Ser Gly Gly Pro 
        35                  40                  45


Ala Glu Arg Ala Gly Leu Gln Gln Leu Asp Thr Val Leu Gln Leu Asn 
    50                  55                  60


Glu Arg Pro Val Glu His Trp Lys Cys Val Glu Leu Ala His Glu Ile 
65                  70                  75                  80


Arg Ser Cys Pro Ser Glu Ile Ile Leu Leu Val Trp Arg Met Val Pro 
                85                  90                  95


Gln Val Lys Pro Gly Pro Asp Gly Gly Val Leu Arg Arg Ala Ser Cys 
            100                 105                 110


Lys Ser Thr His Asp Leu Gln Ser Pro Pro Asn Lys Arg Glu Lys Asn 
        115                 120                 125


Cys Thr His Gly Val Gln Ala Arg Pro Glu Gln Arg His Ser Cys His 
    130                 135                 140


Leu Val Cys Asp Ser Ser Asp Gly Leu Leu Leu Gly Gly Trp Glu Arg 
145                 150                 155                 160


Tyr Thr Glu Val Ala Lys Arg Gly Gly Gln His Thr Leu Pro Ala Leu 
                165                 170                 175


Ser Arg Ala Thr Ala Pro Thr Asp Pro Asn Tyr Ile Ile Leu Ala Pro 
            180                 185                 190


Leu Asn Pro Gly Ser Gln Leu Leu Arg Pro Val Tyr Gln Glu Asp Thr 
        195                 200                 205


Ile Pro Glu Glu Ser Gly Ser Pro Ser Lys Gly Lys Ser Tyr Thr Gly 
    210                 215                 220


Leu Gly Lys Lys Ser Arg Leu Met Lys Thr Val Gln Thr Met Lys Gly 
225                 230                 235                 240


His Gly Asn Tyr Gln Asn Cys Pro Val Val Arg Pro His Ala Thr His 
                245                 250                 255


Ser Ser Tyr Gly Thr Tyr Val Thr Leu Ala Pro Lys Val Leu Val Phe 
            260                 265                 270


Pro Val Phe Val Gln Pro Leu Asp Leu Cys Asn Pro Ala Arg Thr Leu 
        275                 280                 285


Leu Leu Ser Glu Glu Leu Leu Leu Tyr Glu Gly Arg Asn Lys Ala Ala 
    290                 295                 300


Glu Val Thr Leu Phe Ala Tyr Ser Asp Leu Leu Leu Phe Thr Lys Glu 
305                 310                 315                 320


Asp Glu Pro Gly Arg Cys Asp Val Leu Arg Asn Pro Leu Tyr Leu Gln 
                325                 330                 335


Ser Val Lys Leu Gln Glu Gly Ser Ser Glu Asp Leu Lys Phe Cys Val 
            340                 345                 350


Leu Tyr Leu Ala Glu Lys Ala Glu Cys Leu Phe Thr Leu Glu Ala His 
        355                 360                 365


Ser Gln Glu Gln Lys Lys Arg Val Cys Trp Cys Leu Ser Glu Asn Ile 
    370                 375                 380


Ala Lys Gln Gln Gln Leu Ala Ala Ser Pro Pro Asp Ser Lys Met Phe 
385                 390                 395                 400


Glu Thr Glu Ala Asp Glu Lys Arg Glu Met Ala Leu Glu Glu Gly Lys 
                405                 410                 415


Gly Pro Gly Ala Glu Asp Ser Pro Pro Ser Lys Glu Pro Ser Pro Gly 
            420                 425                 430


Gln Glu Leu Pro Pro Gly Gln Asp Leu Pro Pro Asn Lys Asp Ser Pro 
        435                 440                 445


Ser Gly Gln Glu Pro Ala Pro Ser Gln Glu Pro Leu Ser Ser Lys Asp 
    450                 455                 460


Ser Ala Thr Ser Glu Gly Ser Pro Pro Gly Pro Asp Ala Pro Pro Ser 
465                 470                 475                 480


Lys Asp Val Pro Pro Cys Gln Glu Pro Pro Pro Ala Gln Asp Leu Ser 
                485                 490                 495


Pro Cys Gln Asp Leu Pro Ala Gly Gln Glu Pro Leu Pro His Gln Asp 
            500                 505                 510


Pro Leu Leu Thr Lys Asp Leu Pro Ala Ile Gln Glu Ser Pro Thr Arg 
        515                 520                 525


Asp Leu Pro Pro Cys Gln Asp Leu Pro Pro Ser Gln Val Ser Leu Pro 
    530                 535                 540


Ala Lys Ala Leu Thr Glu Asp Thr Met Ser Ser Gly Asp Leu Leu Ala 
545                 550                 555                 560


Ala Thr Gly Asp Pro Pro Ala Ala Pro Arg Pro Ala Phe Val Ile Pro 
                565                 570                 575


Glu Val Arg Leu Asp Ser Thr Tyr Ser Gln Lys Ala Gly Ala Glu Gln 
            580                 585                 590


Gly Cys Ser Gly Asp Glu Glu Asp Ala Glu Glu Ala Glu Glu Val Glu 
        595                 600                 605


Glu Gly Glu Glu Gly Glu Glu Asp Glu Asp Glu Asp Thr Ser Asp Asp 
    610                 615                 620


Asn Tyr Gly Glu Arg Ser Glu Ala Lys Arg Ser Ser Met Ile Glu Thr 
625                 630                 635                 640


Gly Gln Gly Ala Glu Gly Gly Leu Ser Leu Arg Val Gln Asn Ser Leu 
                645                 650                 655


Arg Arg Arg Thr His Ser Glu Gly Ser Leu Leu Gln Glu Pro Arg Gly 
            660                 665                 670


Pro Cys Phe Ala Ser Asp Thr Thr Leu His Cys Ser Asp Gly Glu Gly 
        675                 680                 685


Ala Ala Ser Thr Trp Gly Met Pro Ser Pro Ser Thr Leu Lys Lys Glu 
    690                 695                 700


Leu Gly Arg Asn Gly Gly Ser Met His His Leu Ser Leu Phe Phe Thr 
705                 710                 715                 720


Gly His Arg Lys Met Ser Gly Ala Asp Thr Val Gly Asp Asp Asp Glu 
                725                 730                 735


Ala Ser Arg Lys Arg Lys Ser Lys Asn Leu Ala Lys Asp Met Lys Asn 
            740                 745                 750


Lys Leu Gly Ile Phe Arg Arg Arg Asn Glu Ser Pro Gly Ala Pro Pro 
        755                 760                 765


Ala Gly Lys Ala Asp Lys Met Met Lys Ser Phe Lys Pro Thr Ser Glu 
    770                 775                 780


Glu Ala Leu Lys Trp Gly Glu Ser Leu Glu Lys Leu Leu Val His Lys 
785                 790                 795                 800


Tyr Gly Leu Ala Val Phe Gln Ala Phe Leu Arg Thr Glu Phe Ser Glu 
                805                 810                 815


Glu Asn Leu Glu Phe Trp Leu Ala Cys Glu Asp Phe Lys Lys Val Lys 
            820                 825                 830


Ser Gln Ser Lys Met Ala Ser Lys Ala Lys Lys Ile Phe Ala Glu Tyr 
        835                 840                 845


Ile Ala Ile Gln Ala Cys Lys Glu Val Asn Leu Asp Ser Tyr Thr Arg 
    850                 855                 860


Glu His Thr Lys Asp Asn Leu Gln Ser Val Thr Arg Gly Cys Phe Asp 
865                 870                 875                 880


Leu Ala Gln Lys Arg Ile Phe Gly Leu Met Glu Lys Asp Ser Tyr Pro 
                885                 890                 895


Arg Phe Leu Arg Ser Asp Leu Tyr Leu Asp Leu Ile Asn Gln Lys Lys 
            900                 905                 910


Met Ser Pro Pro Leu 
        915


<210>  641
<211>  1582
<212>  DNA
<213>  Homo sapiens

<400>  641
ggatggacgc ctctcccccg gagcagcact ttggggccag cttgggccct ggggatgagc     60

cacaggggac ccacagccta tgcgtgtgag catgtaaccc gggagccagc tgggcccctc    120

gcggggtggg cagaaggacg ggctggccca ggaccctctt ctttgagaca tcccggactc    180

catctcggat gaaagtgctt tgagaaacca cagagttttc tgtttaatgg aagaaagaaa    240

tccagcctct ctccagagtg gcggtggccg gctagacagg agccaaggac atgaagaaca    300

agctggggat cttcagacgg cggaatgagt cccctggagc ccctcccgcg ggcaaggcag    360

acaaaatgat gaagtcattc aagcccacct cagaggaagc cctcaagtgg ggcgagtcct    420

tggagaagct gctggttcac aaatacgggt tagcagtgtt ccaagccttc cttcgcactg    480

agttcagtga ggagaatctg gagttctggt tggcttgtga ggacttcaag aaggtcaagt    540

cacagtccaa gatggcatcc aaggccaaga agatctttgc tgaatacatc gcgatccagg    600

catgcaagga ggtcaacctg gactcctaca cgcgggagca caccaaggac aacctgcaga    660

gcgtcacgcg gggctgcttc gacctggcac agaagcgcat cttcgggctc atggaaaagg    720

actcgtaccc tcgctttctc cgttctgacc tctacctgga ccttattaac cagaagaaga    780

tgagtccccc gctttagggg ccactggagt cgagctcagc gttcacacca ggcgggctgg    840

gtcccctgcc cacctgcctc cctgccccct gtgacggagg gggcaagcaa gcccccagag    900

gctgtgtctc tggacagacg gatagacata cggaagcgag gcctggacca agagaggccc    960

aggctactgg aggagtagaa ggatgggccc cgtggggtcc ccactgcccc ggtacgaggg   1020

ggcccaagac cctggcaggt caggggccct ggccaagcca gatctggagc tgctgctccc   1080

tgctgcggag accgcggagg cttcgcgttg accaagttcc ttaaagaact ggctgatggg   1140

gcaggaggtc caggcctggg ctctcgggcc ctcctagagg gccattggag cttgcagctc   1200

agacccccac tttgagtttt atttatttaa atagtagttg gatgcttggc acgtcgtcct   1260

gtaataggaa acccttgcct catcagtttt cctgatttac aagtgcaata ttttagccaa   1320

tgccttggga gaagctgcca tgcaaaggtg gacaccattc tccagcttca ggggatatgc   1380

tcgtcccggg caccggtggc aggcagctgg ccttctggac taaggcagcc tggggggaca   1440

ctgcagtctg gctacacaca gagatctggc accccctggg tggagtgtcc ctcgggggct   1500

ttgggaaagc atggcaccct cagaccacac agtagccaag ttctggagca aataaaaggc   1560

ctgtgttatt tcttgttctt ga                                            1582


<210>  642
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  642

Met Lys Asn Lys Leu Gly Ile Phe Arg Arg Arg Asn Glu Ser Pro Gly 
1               5                   10                  15


Ala Pro Pro Ala Gly Lys Ala Asp Lys Met Met Lys Ser Phe Lys Pro 
            20                  25                  30


Thr Ser Glu Glu Ala Leu Lys Trp Gly Glu Ser Leu Glu Lys Leu Leu 
        35                  40                  45


Val His Lys Tyr Gly Leu Ala Val Phe Gln Ala Phe Leu Arg Thr Glu 
    50                  55                  60


Phe Ser Glu Glu Asn Leu Glu Phe Trp Leu Ala Cys Glu Asp Phe Lys 
65                  70                  75                  80


Lys Val Lys Ser Gln Ser Lys Met Ala Ser Lys Ala Lys Lys Ile Phe 
                85                  90                  95


Ala Glu Tyr Ile Ala Ile Gln Ala Cys Lys Glu Val Asn Leu Asp Ser 
            100                 105                 110


Tyr Thr Arg Glu His Thr Lys Asp Asn Leu Gln Ser Val Thr Arg Gly 
        115                 120                 125


Cys Phe Asp Leu Ala Gln Lys Arg Ile Phe Gly Leu Met Glu Lys Asp 
    130                 135                 140


Ser Tyr Pro Arg Phe Leu Arg Ser Asp Leu Tyr Leu Asp Leu Ile Asn 
145                 150                 155                 160


Gln Lys Lys Met Ser Pro Pro Leu 
                165


<210>  643
<211>  4643
<212>  DNA
<213>  Homo sapiens

<400>  643
aactttggct cagcctgtct tcatccactg tatcctgaca cctctcctac tccttctctt     60

taatgtacag ctgagactgg gataccctta gactgaaagg aaggacacgg ctatgtagaa    120

aagaattgac tgaaggggag gagtactcgt gaaccccttg cttcagcctc ccaatgttct    180

gagagaggag gagccaggcg cagtggctca tgcctgtaat cccagcactt tgggaggttg    240

agatgggcag atcgcaaggt caggagatcg agaccatcct ggctaacagg tcacattcag    300

acagcacacc tttgcccaat tttctttctg gatctcaccg tcctgagtgt tgtacctgca    360

ggttgctcac agcctctgga gcccaagata gtctcccctt tgggaggagg ctctacagtg    420

gtccctggcg aagttgtgaa gaggtctgcc acgtctctgt gctcagtgtc ctctctacat    480

cctgtggctt gagcctgagc ttgcccatat tccctggctg gatggagtgg ctaagccctg    540

atatcgctct gcccagaaga gatgagtgga ctcaaacttc tccagccagg aagaggatca    600

cgcatgccaa agtccagggt gcaggtcagc tgaggctgtc cattgatgcc caggaccggg    660

ttctgctgct tcacattata gaaggtaaag gcctgatcag caaacagcct ggcacctgtg    720

atccgtatgt gaagatttct ttgatccctg aagatagtag actacgccac cagaagacgc    780

agaccgttcc agactgcaga gacccggctt tccacgagca cttcttcttt cctgtccaag    840

aggaggatga tcagaagcgt ctcttggtta ctgtgtggaa cagggccagc cagtccagac    900

agagtggact cattggctgc atgagctttg gggtgaagtc tctcctgact ccagacaagg    960

agatcagtgg ttggtactac ctcctagggg agcacctggg ccggaccaag cacttgaagg   1020

tggccaggcg gcgactgcgg ccgctgagag acccgctgct gagaatgcca ggaggtgggg   1080

acactgagaa tgggaagaaa ctaaagatca ccatcccgag gggaaaggac ggctttggct   1140

tcaccatctg ctgcgactct ccagttcgag tccaggccgt ggattccggg ggtccggcgg   1200

aacgggcagg gctgcagcag ctggacacgg tgctgcagct gaatgagagg cctgtggagc   1260

actggaaatg tgtggagctg gcccacgaga tccggagctg ccccagtgag atcatcctac   1320

tcgtgtggcg catggtcccc caggtcaagc caggaccaga tggcggggtc ctgcggcggg   1380

cctcctgcaa gtcgacacat gacctccagt caccccccaa caaacgggag aagaactgca   1440

cccatggggt ccaggcacgg cctgagcagc gccacagctg ccacctggta tgtgacagct   1500

ctgatgggct gctgctcggc ggctgggagc gctacaccga ggtggccaag cgcgggggcc   1560

agcacaccct gcctgcactg tcccgtgcca ctgcccccac cgaccccaac tacatcatcc   1620

tggccccgct gaatcctggg agccagctgc tccggcctgt gtaccaggag gataccatcc   1680

ccgaagaatc agggagtccc agtaaaggga agtcctacac aggcctgggg aagaagtccc   1740

ggctgatgaa gacagtgcag accatgaagg gccacgggaa ctaccaaaac tgcccggttg   1800

tgaggccgca tgccacgcac tcaagctatg gcacctacgt caccctggcc cccaaagtcc   1860

tggtgttccc tgtctttgtt cagcctctag atctctgtaa tcctgcccgg accctcctgc   1920

tgtcagagga gctgctgctg tatgaaggga ggaacaaggc tgccgaggtg acactgtttg   1980

cctattcgga cctgctgctc ttcaccaagg aggacgagcc tggccgctgc gacgtcctga   2040

ggaaccccct ctacctccag agtgtgaagc tgcaggaagg ttcttcagaa gacctgaaat   2100

tctgcgtgct ctatctagca gagaaggcag agtgcttatt cactttggaa gcgcactcgc   2160

aggagcagaa gaagagagtg tgctggtgcc tgtcggagaa catcgccaag cagcaacagc   2220

tggcagcatc acccccggac agcaagatgt ttgagacgga ggcagatgag aagagggaga   2280

tggccttgga ggaagggaag gggcctggtg ccgaggattc cccacccagc aaggagccct   2340

ctcctggcca ggagcttcct ccaggacaag accttccacc caacaaggac tccccttctg   2400

ggcaggaacc cgctcccagc caagaaccac tgtccagcaa agactcagct acctctgaag   2460

gatcccctcc aggcccagat gctccgccca gcaaggatgt gccaccatgc caggaacccc   2520

ctccagccca agacctctca ccctgccagg acctacctgc tggtcaagaa cccctgcctc   2580

accaggaccc tctactcacc aaagacctcc ctgccatcca ggaatccccc acccgggacc   2640

ttccaccctg tcaagatctg cctcctagcc aggtctccct gccagccaag gcccttactg   2700

aggacaccat gagctccggg gacctactag cagctactgg ggacccacct gcggccccca   2760

ggccagcctt cgtgatccct gaggtccggc tggatagcac ctacagccag aaggcagggg   2820

cagagcaggg ctgctcggga gatgaggagg atgcagaaga ggccgaggag gtggaggagg   2880

gggaggaagg ggaggaggac gaggatgagg acaccagcga tgacaactac ggagagcgca   2940

gtgaggccaa gcgcagcagc atgatcgaga cgggccaggg ggctgagggt ggcctctcac   3000

tgcgtgtgca gaactcgctg cggcgccgga cgcacagcga gggcagcctg ctgcaggagc   3060

cccgagggcc ctgctttgcc tccgacacca ccttgcactg ctcagacggt gagggcgccg   3120

cctccacctg gggcatgcct tcgcccagca ccctcaagaa agagctgggc cgcaatggtg   3180

gctccatgca ccacctttcc ctcttcttca caggacacag gaagatgagc ggggctgaca   3240

ccgttgggga tgatgacgaa gcctcccgga agagaaagag caaaaaccta gccaaggaca   3300

tgaagaacaa gctggggatc ttcagacggc ggaatgagtc ccctggagcc cctcccgcgg   3360

gcaaggcaga caaaatgatg aagtcattca agcccacctc agaggaagcc ctcaagtggg   3420

gcgagtcctt ggagaagctg ctggttcaca aatacgggtt agcagtgttc caagccttcc   3480

ttcgcactga gttcagtgag gagaatctgg agttctggtt ggcttgtgag gacttcaaga   3540

aggtcaagtc acagtccaag atggcatcca aggccaagaa gatctttgct gaatacatcg   3600

cgatccaggc atgcaaggag gtcaacctgg actcctacac gcgggagcac accaaggaca   3660

acctgcagag cgtcacgcgg ggctgcttcg acctggcaca gaagcgcatc ttcgggctca   3720

tggaaaagga ctcgtaccct cgctttctcc gttctgacct ctacctggac cttattaacc   3780

agaagaagat gagtcccccg ctttaggggc cactggagtc gagctcagcg ttcacaccag   3840

gcgggctggg tcccctgccc acctgcctcc ctgccccctg tgacggaggg ggcaagcaag   3900

cccccagagg ctgtgtctct ggacagacgg atagacatac ggaagcgagg cctggaccaa   3960

gagaggccca ggctactgga ggagtagaag gatgggcccc gtggggtccc cactgccccg   4020

gtacgagggg gcccaagacc ctggcaggtc aggggccctg gccaagccag atctggagct   4080

gctgctccct gctgcggaga ccgcggaggc ttcgcgttga ccaagttcct taaagaactg   4140

gctgatgggg caggaggtcc aggcctgggc tctcgggccc tcctagaggg ccattggagc   4200

ttgcagctca gacccccact ttgagtttta tttatttaaa tagtagttgg atgcttggca   4260

cgtcgtcctg taataggaaa cccttgcctc atcagttttc ctgatttaca agtgcaatat   4320

tttagccaat gccttgggag aagctgccat gcaaaggtgg acaccattct ccagcttcag   4380

gggatatgct cgtcccgggc accggtggca ggcagctggc cttctggact aaggcagcct   4440

ggggggacac tgcagtctgg ctacacacag agatctggca ccccctgggt ggagtgtccc   4500

tcgggggctt tgggaaagca tggcaccctc agaccacaca gtagccaagt tctggagcaa   4560

ataaaaggcc tgtgttattt cttgttcttg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   4620

aaaaaaaaaa aaaaaaaaaa aaa                                           4643


<210>  644
<211>  1198
<212>  PRT
<213>  Homo sapiens

<400>  644

Met Pro Val Ile Pro Ala Leu Trp Glu Val Glu Met Gly Arg Ser Gln 
1               5                   10                  15


Gly Gln Glu Ile Glu Thr Ile Leu Ala Asn Arg Ser His Ser Asp Ser 
            20                  25                  30


Thr Pro Leu Pro Asn Phe Leu Ser Gly Ser His Arg Pro Glu Cys Cys 
        35                  40                  45


Thr Cys Arg Leu Leu Thr Ala Ser Gly Ala Gln Asp Ser Leu Pro Phe 
    50                  55                  60


Gly Arg Arg Leu Tyr Ser Gly Pro Trp Arg Ser Cys Glu Glu Val Cys 
65                  70                  75                  80


His Val Ser Val Leu Ser Val Leu Ser Thr Ser Cys Gly Leu Ser Leu 
                85                  90                  95


Ser Leu Pro Ile Phe Pro Gly Trp Met Glu Trp Leu Ser Pro Asp Ile 
            100                 105                 110


Ala Leu Pro Arg Arg Asp Glu Trp Thr Gln Thr Ser Pro Ala Arg Lys 
        115                 120                 125


Arg Ile Thr His Ala Lys Val Gln Gly Ala Gly Gln Leu Arg Leu Ser 
    130                 135                 140


Ile Asp Ala Gln Asp Arg Val Leu Leu Leu His Ile Ile Glu Gly Lys 
145                 150                 155                 160


Gly Leu Ile Ser Lys Gln Pro Gly Thr Cys Asp Pro Tyr Val Lys Ile 
                165                 170                 175


Ser Leu Ile Pro Glu Asp Ser Arg Leu Arg His Gln Lys Thr Gln Thr 
            180                 185                 190


Val Pro Asp Cys Arg Asp Pro Ala Phe His Glu His Phe Phe Phe Pro 
        195                 200                 205


Val Gln Glu Glu Asp Asp Gln Lys Arg Leu Leu Val Thr Val Trp Asn 
    210                 215                 220


Arg Ala Ser Gln Ser Arg Gln Ser Gly Leu Ile Gly Cys Met Ser Phe 
225                 230                 235                 240


Gly Val Lys Ser Leu Leu Thr Pro Asp Lys Glu Ile Ser Gly Trp Tyr 
                245                 250                 255


Tyr Leu Leu Gly Glu His Leu Gly Arg Thr Lys His Leu Lys Val Ala 
            260                 265                 270


Arg Arg Arg Leu Arg Pro Leu Arg Asp Pro Leu Leu Arg Met Pro Gly 
        275                 280                 285


Gly Gly Asp Thr Glu Asn Gly Lys Lys Leu Lys Ile Thr Ile Pro Arg 
    290                 295                 300


Gly Lys Asp Gly Phe Gly Phe Thr Ile Cys Cys Asp Ser Pro Val Arg 
305                 310                 315                 320


Val Gln Ala Val Asp Ser Gly Gly Pro Ala Glu Arg Ala Gly Leu Gln 
                325                 330                 335


Gln Leu Asp Thr Val Leu Gln Leu Asn Glu Arg Pro Val Glu His Trp 
            340                 345                 350


Lys Cys Val Glu Leu Ala His Glu Ile Arg Ser Cys Pro Ser Glu Ile 
        355                 360                 365


Ile Leu Leu Val Trp Arg Met Val Pro Gln Val Lys Pro Gly Pro Asp 
    370                 375                 380


Gly Gly Val Leu Arg Arg Ala Ser Cys Lys Ser Thr His Asp Leu Gln 
385                 390                 395                 400


Ser Pro Pro Asn Lys Arg Glu Lys Asn Cys Thr His Gly Val Gln Ala 
                405                 410                 415


Arg Pro Glu Gln Arg His Ser Cys His Leu Val Cys Asp Ser Ser Asp 
            420                 425                 430


Gly Leu Leu Leu Gly Gly Trp Glu Arg Tyr Thr Glu Val Ala Lys Arg 
        435                 440                 445


Gly Gly Gln His Thr Leu Pro Ala Leu Ser Arg Ala Thr Ala Pro Thr 
    450                 455                 460


Asp Pro Asn Tyr Ile Ile Leu Ala Pro Leu Asn Pro Gly Ser Gln Leu 
465                 470                 475                 480


Leu Arg Pro Val Tyr Gln Glu Asp Thr Ile Pro Glu Glu Ser Gly Ser 
                485                 490                 495


Pro Ser Lys Gly Lys Ser Tyr Thr Gly Leu Gly Lys Lys Ser Arg Leu 
            500                 505                 510


Met Lys Thr Val Gln Thr Met Lys Gly His Gly Asn Tyr Gln Asn Cys 
        515                 520                 525


Pro Val Val Arg Pro His Ala Thr His Ser Ser Tyr Gly Thr Tyr Val 
    530                 535                 540


Thr Leu Ala Pro Lys Val Leu Val Phe Pro Val Phe Val Gln Pro Leu 
545                 550                 555                 560


Asp Leu Cys Asn Pro Ala Arg Thr Leu Leu Leu Ser Glu Glu Leu Leu 
                565                 570                 575


Leu Tyr Glu Gly Arg Asn Lys Ala Ala Glu Val Thr Leu Phe Ala Tyr 
            580                 585                 590


Ser Asp Leu Leu Leu Phe Thr Lys Glu Asp Glu Pro Gly Arg Cys Asp 
        595                 600                 605


Val Leu Arg Asn Pro Leu Tyr Leu Gln Ser Val Lys Leu Gln Glu Gly 
    610                 615                 620


Ser Ser Glu Asp Leu Lys Phe Cys Val Leu Tyr Leu Ala Glu Lys Ala 
625                 630                 635                 640


Glu Cys Leu Phe Thr Leu Glu Ala His Ser Gln Glu Gln Lys Lys Arg 
                645                 650                 655


Val Cys Trp Cys Leu Ser Glu Asn Ile Ala Lys Gln Gln Gln Leu Ala 
            660                 665                 670


Ala Ser Pro Pro Asp Ser Lys Met Phe Glu Thr Glu Ala Asp Glu Lys 
        675                 680                 685


Arg Glu Met Ala Leu Glu Glu Gly Lys Gly Pro Gly Ala Glu Asp Ser 
    690                 695                 700


Pro Pro Ser Lys Glu Pro Ser Pro Gly Gln Glu Leu Pro Pro Gly Gln 
705                 710                 715                 720


Asp Leu Pro Pro Asn Lys Asp Ser Pro Ser Gly Gln Glu Pro Ala Pro 
                725                 730                 735


Ser Gln Glu Pro Leu Ser Ser Lys Asp Ser Ala Thr Ser Glu Gly Ser 
            740                 745                 750


Pro Pro Gly Pro Asp Ala Pro Pro Ser Lys Asp Val Pro Pro Cys Gln 
        755                 760                 765


Glu Pro Pro Pro Ala Gln Asp Leu Ser Pro Cys Gln Asp Leu Pro Ala 
    770                 775                 780


Gly Gln Glu Pro Leu Pro His Gln Asp Pro Leu Leu Thr Lys Asp Leu 
785                 790                 795                 800


Pro Ala Ile Gln Glu Ser Pro Thr Arg Asp Leu Pro Pro Cys Gln Asp 
                805                 810                 815


Leu Pro Pro Ser Gln Val Ser Leu Pro Ala Lys Ala Leu Thr Glu Asp 
            820                 825                 830


Thr Met Ser Ser Gly Asp Leu Leu Ala Ala Thr Gly Asp Pro Pro Ala 
        835                 840                 845


Ala Pro Arg Pro Ala Phe Val Ile Pro Glu Val Arg Leu Asp Ser Thr 
    850                 855                 860


Tyr Ser Gln Lys Ala Gly Ala Glu Gln Gly Cys Ser Gly Asp Glu Glu 
865                 870                 875                 880


Asp Ala Glu Glu Ala Glu Glu Val Glu Glu Gly Glu Glu Gly Glu Glu 
                885                 890                 895


Asp Glu Asp Glu Asp Thr Ser Asp Asp Asn Tyr Gly Glu Arg Ser Glu 
            900                 905                 910


Ala Lys Arg Ser Ser Met Ile Glu Thr Gly Gln Gly Ala Glu Gly Gly 
        915                 920                 925


Leu Ser Leu Arg Val Gln Asn Ser Leu Arg Arg Arg Thr His Ser Glu 
    930                 935                 940


Gly Ser Leu Leu Gln Glu Pro Arg Gly Pro Cys Phe Ala Ser Asp Thr 
945                 950                 955                 960


Thr Leu His Cys Ser Asp Gly Glu Gly Ala Ala Ser Thr Trp Gly Met 
                965                 970                 975


Pro Ser Pro Ser Thr Leu Lys Lys Glu Leu Gly Arg Asn Gly Gly Ser 
            980                 985                 990


Met His His Leu Ser Leu Phe Phe Thr Gly His Arg Lys Met Ser Gly 
        995                 1000                1005


Ala Asp Thr Val Gly Asp Asp Asp Glu Ala Ser Arg Lys Arg Lys Ser 
    1010                1015                1020


Lys Asn Leu Ala Lys Asp Met Lys Asn Lys Leu Gly Ile Phe Arg Arg 
1025                1030                1035                1040


Arg Asn Glu Ser Pro Gly Ala Pro Pro Ala Gly Lys Ala Asp Lys Met 
                1045                1050                1055


Met Lys Ser Phe Lys Pro Thr Ser Glu Glu Ala Leu Lys Trp Gly Glu 
            1060                1065                1070


Ser Leu Glu Lys Leu Leu Val His Lys Tyr Gly Leu Ala Val Phe Gln 
        1075                1080                1085


Ala Phe Leu Arg Thr Glu Phe Ser Glu Glu Asn Leu Glu Phe Trp Leu 
    1090                1095                1100


Ala Cys Glu Asp Phe Lys Lys Val Lys Ser Gln Ser Lys Met Ala Ser 
1105                1110                1115                1120


Lys Ala Lys Lys Ile Phe Ala Glu Tyr Ile Ala Ile Gln Ala Cys Lys 
                1125                1130                1135


Glu Val Asn Leu Asp Ser Tyr Thr Arg Glu His Thr Lys Asp Asn Leu 
            1140                1145                1150


Gln Ser Val Thr Arg Gly Cys Phe Asp Leu Ala Gln Lys Arg Ile Phe 
        1155                1160                1165


Gly Leu Met Glu Lys Asp Ser Tyr Pro Arg Phe Leu Arg Ser Asp Leu 
    1170                1175                1180


Tyr Leu Asp Leu Ile Asn Gln Lys Lys Met Ser Pro Pro Leu 
1185                1190                1195


<210>  645
<211>  1773
<212>  DNA
<213>  Homo sapiens

<400>  645
atggtaacga ggaggccagt cacaaatagc tgggactggc ttcctgccgg ggcggcccca     60

gaggctgtcc cttgcagaca catgcccctt tcacggctcc ctctcagggt tggccagaag    120

gaattttttt ttccgctccc cctcctggtc cctcccattt cctggctcct cctgtctgag    180

tcccagcccc ggcttgtgcc tgggagtcca gtcatcaggc caggattcca gagagcgtgt    240

gtggctgcag cctgcaccgt tgctgcccgc tgcccaggac gcggggtggg ggacaggagc    300

cagagtggtg cctcctacag accaatctgc ggccccaagg tggggggccc tacagagatg    360

ctccgaggca tgtacctcac tcgcaacggg aacctgcaga ggcgacacac gatgaaggaa    420

gccaaggaca tgaagaacaa gctggggatc ttcagacggc ggaatgagtc ccctggagcc    480

cctcccgcgg gcaaggcaga caaaatgatg aagtcattca agcccacctc agaggaagcc    540

ctcaagtggg gcgagtcctt ggagaagctg ctggttcaca aatacgggtt agcagtgttc    600

caagccttcc ttcgcactga gttcagtgag gagaatctgg agttctggtt ggcttgtgag    660

gacttcaaga aggtcaagtc acagtccaag atggcatcca aggccaagaa gatctttgct    720

gaatacatcg cgatccaggc atgcaaggag gtcaacctgg actcctacac gcgggagcac    780

accaaggaca acctgcagag cgtcacgcgg ggctgcttcg acctggcaca gaagcgcatc    840

ttcgggctca tggaaaagga ctcgtaccct cgctttctcc gttctgacct ctacctggac    900

cttattaacc agaagaagat gagtcccccg ctttaggggc cactggagtc gagctcagcg    960

ttcacaccag gcgggctggg tcccctgccc acctgcctcc ctgccccctg tgacggaggg   1020

ggcaagcaag cccccagagg ctgtgtctct ggacagacgg atagacatac ggaagcgagg   1080

cctggaccaa gagaggccca ggctactgga ggagtagaag gatgggcccc gtggggtccc   1140

cactgccccg gtacgagggg gcccaagacc ctggcaggtc aggggccctg gccaagccag   1200

atctggagct gctgctccct gctgcggaga ccgcggaggc ttcgcgttga ccaagttcct   1260

taaagaactg gctgatgggg caggaggtcc aggcctgggc tctcgggccc tcctagaggg   1320

ccattggagc ttgcagctca gacccccact ttgagtttta tttatttaaa tagtagttgg   1380

atgcttggca cgtcgtcctg taataggaaa cccttgcctc atcagttttc ctgatttaca   1440

agtgcaatat tttagccaat gccttgggag aagctgccat gcaaaggtgg acaccattct   1500

ccagcttcag gggatatgct cgtcccgggc accggtggca ggcagctggc cttctggact   1560

aaggcagcct ggggggacac tgcagtctgg ctacacacag agatctggca ccccctgggt   1620

ggagtgtccc tcgggggctt tgggaaagca tggcaccctc agaccacaca gtagccaagt   1680

tctggagcaa ataaaaggcc tgtgttattt cttgttcttg aaaaaaaaaa aaaaaaaaaa   1740

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                                1773


<210>  646
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  646

Met Val Thr Arg Arg Pro Val Thr Asn Ser Trp Asp Trp Leu Pro Ala 
1               5                   10                  15


Gly Ala Ala Pro Glu Ala Val Pro Cys Arg His Met Pro Leu Ser Arg 
            20                  25                  30


Leu Pro Leu Arg Val Gly Gln Lys Glu Phe Phe Phe Pro Leu Pro Leu 
        35                  40                  45


Leu Val Pro Pro Ile Ser Trp Leu Leu Leu Ser Glu Ser Gln Pro Arg 
    50                  55                  60


Leu Val Pro Gly Ser Pro Val Ile Arg Pro Gly Phe Gln Arg Ala Cys 
65                  70                  75                  80


Val Ala Ala Ala Cys Thr Val Ala Ala Arg Cys Pro Gly Arg Gly Val 
                85                  90                  95


Gly Asp Arg Ser Gln Ser Gly Ala Ser Tyr Arg Pro Ile Cys Gly Pro 
            100                 105                 110


Lys Val Gly Gly Pro Thr Glu Met Leu Arg Gly Met Tyr Leu Thr Arg 
        115                 120                 125


Asn Gly Asn Leu Gln Arg Arg His Thr Met Lys Glu Ala Lys Asp Met 
    130                 135                 140


Lys Asn Lys Leu Gly Ile Phe Arg Arg Arg Asn Glu Ser Pro Gly Ala 
145                 150                 155                 160


Pro Pro Ala Gly Lys Ala Asp Lys Met Met Lys Ser Phe Lys Pro Thr 
                165                 170                 175


Ser Glu Glu Ala Leu Lys Trp Gly Glu Ser Leu Glu Lys Leu Leu Val 
            180                 185                 190


His Lys Tyr Gly Leu Ala Val Phe Gln Ala Phe Leu Arg Thr Glu Phe 
        195                 200                 205


Ser Glu Glu Asn Leu Glu Phe Trp Leu Ala Cys Glu Asp Phe Lys Lys 
    210                 215                 220


Val Lys Ser Gln Ser Lys Met Ala Ser Lys Ala Lys Lys Ile Phe Ala 
225                 230                 235                 240


Glu Tyr Ile Ala Ile Gln Ala Cys Lys Glu Val Asn Leu Asp Ser Tyr 
                245                 250                 255


Thr Arg Glu His Thr Lys Asp Asn Leu Gln Ser Val Thr Arg Gly Cys 
            260                 265                 270


Phe Asp Leu Ala Gln Lys Arg Ile Phe Gly Leu Met Glu Lys Asp Ser 
        275                 280                 285


Tyr Pro Arg Phe Leu Arg Ser Asp Leu Tyr Leu Asp Leu Ile Asn Gln 
    290                 295                 300


Lys Lys Met Ser Pro Pro Leu 
305                 310


<210>  647
<211>  11025
<212>  DNA
<213>  Homo sapiens

<400>  647
gagcatcttt tggggggagg gaattcagcg gatcagtctt aagaggagct tttttttgga     60

gcgagaaatc atataaaata aaatgaaata aaacaaggag gaaggcaacc agctgttagg    120

ggaaaaataa ggcagataaa ggagcgggga gagaaattaa ttgccaacca ggaggagttg    180

ggctgtattt ttcaaaggtg gggagagtgg agcacacacc ttgaggagga aagcgagaaa    240

gaaaagaaaa aagcaagtgg aaaggggggc tcgcccaaga agggtgaaga agcgaagaaa    300

gtcgaggcgc cgaggctccc aaagctggca gctccgggtg gcggtgcagg ggcgaagggg    360

gggcgggggg aaccgtcgga catgcggctc tggagttggg tgctgcacct ggggctgctg    420

agcgccgcgc tgggctgcgg gctggccgag cgtccccgcc gggcccggag agacccgcgg    480

gccggccgac ccccgcgccc cgccgccggc ccggccacct gcgccacccg ggcggcccgc    540

ggccgccgcg cctcgccgcc gccgccgccg ccgccgggcg gtgcctggga agccgtgcgc    600

gtcccccggc ggcggcagca gcgggaggcg aggggcgcca ccgaggagcc gagcccgccg    660

agccgggcgc tctatttcag cgggcgaggc gagcagctgc gcctccgggc cgacctcgag    720

ctgccccggg acgcgttcac gctgcaagtg tggctgcgag cggagggggg ccagaggtct    780

ccggcagtga tcacagggct gtatgacaaa tgttcttata tctcacgtga ccgaggatgg    840

gtcgtgggca ttcacaccat cagtgaccaa gacaacaaag acccacgcta ctttttctcc    900

ttgaagacag accgagcccg gcaagtgacc accatcaatg cccaccgcag ctacctccca    960

ggccagtggg tatacctagc tgccacctat gatgggcagt tcatgaagct ctatgtgaat   1020

ggtgcccagg tggccacctc tggggaacaa gtgggtggca tattcagccc actgacccag   1080

aagtgcaaag tgctcatgtt agggggcagt gccctgaatc acaactaccg gggctacatc   1140

gagcacttca gtctgtggaa ggtggccagg actcagcggg agatactgtc tgacatggaa   1200

acccatggcg cccacactgc tctacctcag ctcctcctcc aggagaactg ggacaatgtg   1260

aagcatgcct ggtcccccat gaaggatggc agcagcccca aagtggaatt cagcaatgcc   1320

cacggctttc tgctggacac gagtctggag cctcctctgt gcggacagac attgtgtgac   1380

aacacagagg tcattgccag ctacaatcag ctctcaagtt tccgccagcc caaggtggtg   1440

cgctaccgcg tggtcaacct ctatgaagat gatcataaga acccgacggt gacgcgcgag   1500

caggtggact tccagcacca tcagctggct gaggccttca agcaatacaa catctcctgg   1560

gagctggacg tgctggaggt gagcaactcc tcccttcgcc gccgcctcat cctggccaac   1620

tgtgacatca gcaagattgg ggatgagaac tgtgaccccg agtgcaacca cacgctgacg   1680

ggccacgacg gcggggattg ccgccacctg cgccaccctg ccttcgtgaa gaagcagcac   1740

aacggggtgt gtgacatgga ctgcaactat gaacggttca actttgatgg tggagagtgc   1800

tgtgaccctg aaatcaccaa tgtcactcag acttgctttg accccgactc tccacacaga   1860

gcctacttgg atgttaatga gctgaagaac attcttaaat tggatggatc aacacatctc   1920

aatattttct ttgcaaaatc ctcagaggag gagttggcag gagtagcaac ttggccatgg   1980

gacaaggagg ccctgatgca cttaggtggc attgtcttga acccatcttt ctatggcatg   2040

cctgggcaca cccacaccat gatccatgag attggtcaca gcctgggcct ctatcacgtc   2100

ttccgaggca tctcagaaat ccagtcctgc agtgacccct gcatggagac agagccctcc   2160

ttcgagactg gagacctctg caatgatacc aacccagccc ctaaacacaa gtcctgtggt   2220

gacccagggc caggaaatga cacctgtggc tttcatagct tcttcaacac tccttacaac   2280

aacttcatga gctatgcaga tgacgactgt acggactcct tcacgcccaa tcaagtcgcc   2340

agaatgcact gttacctgga cctggtctac cagggctggc agccctccag gaaaccagcg   2400

cctgttgccc tcgcccccca agttctgggc cacacaacgg actctgtgac actggagtgg   2460

ttcccaccta tagatggcca tttctttgaa agagaattgg gatcagcatg tcatctttgc   2520

ctggaaggga gaatcctggt gcagtatgct tccaacgctt cctccccaat gccctgcagc   2580

ccatcaggac actggagccc tcgtgaagca gaaggtcatc ctgatgttga acagccctgt   2640

aagtccagtg tccgcacctg gagcccaaat tcagctgtca acccacacac ggttcctcca   2700

gcctgccctg agcctcaagg ctgctacctc gagctggagt tcctctaccc cttggtccct   2760

gagtctctga ccatttgggt gacctttgtc tccactgact gggactctag tggagctgtc   2820

aatgacatca aactgttggc tgtcagtggg aagaacatct ccctgggtcc tcagaatgtc   2880

ttctgtgatg tcccactgac catcagactc tgggacgtgg gcgaggaggt gtatggcatc   2940

caaatctaca cgctggatga gcacctggag atcgatgctg ccatgttgac ctccactgca   3000

gacaccccac tctgtctaca gtgtaagccc ctgaagtata aggtggtccg ggaccctcct   3060

ctccagatgg atgtggcctc catcctacat ctcaatagga aattcgtaga catggatcta   3120

aatcttggca gtgtgtacca gtattgggtc ataactattt caggaactga agagagtgag   3180

ccatcacctg ctgtcacata catccatgga agtgggtact gtggcgatgg cattatacaa   3240

aaagaccaag gtgaacaatg cgacgacatg aataagatca atggtgatgg ctgctccctt   3300

ttctgccgac aagaagtctc cttcaattgt attgatgaac ccagccggtg ctatttccat   3360

gatggtgatg gggtatgtga ggagtttgaa caaaaaacca gcattaagga ctgtggtgtc   3420

tacacgcccc agggattcct ggatcagtgg gcatccaatg cttcagtatc tcatcaagac   3480

cagcaatgcc caggctgggt catcatcgga cagccagcag catcccaggt gtgtcgaacc   3540

aaggtgatag atctcagtga aggcatttcc cagcatgcct ggtacccttg caccatcagc   3600

tacccatatt cccagctggc tcagaccact ttttggctcc gggcgtattt ttctcaacca   3660

atggttgccg cagctgtcat tgtccacctg gtgacggatg ggacatatta tggggaccaa   3720

aagcaggaga ccatcagcgt gcagctgctt gataccaaag atcagagcca cgatctaggc   3780

ctccatgtcc tgagctgcag gaacaatccc ctgattatcc ctgtggtcca tgacctcagc   3840

cagcccttct accacagcca ggcggtacgt gtgagcttca gttcgcccct ggtcgccatc   3900

tcgggggtgg ccctccgttc cttcgacaac tttgaccccg tcaccctgag cagctgccag   3960

agaggggaga cctacagccc tgccgagcag agctgcgtgc acttcgcatg tgagaaaact   4020

gactgtccag agctggctgt ggagaatgct tctctcaatt gctccagcag cgaccgctac   4080

cacggtgccc agtgtactgt gagctgccgg acaggctacg tgctccagat acggcgggat   4140

gatgagctga tcaagagcca gacgggaccc agcgtcacag tgacctgtac agagggcaag   4200

tggaataagc aggtggcctg tgagccagtc gactgcagca tcccagatca ccatcaagtc   4260

tatgctgcct ccttctcctg ccctgagggc accacctttg gcagtcaatg ttccttccag   4320

tgccgtcacc ctgcacaatt gaaaggcaac aacagcctcc tgacctgcat ggaggatggg   4380

ctgtggtcct tcccagaggc cctgtgtgag ctcatgtgcc tcgctccacc ccctgtgccc   4440

aatgcagacc tccagaccgc ccggtgccga gagaataagc acaaggtggg ctccttctgc   4500

aaatacaaat gcaagcctgg ataccatgtg cctggatcct ctcggaagtc aaagaaacgg   4560

gccttcaaga ctcagtgtac ccaggatggc agctggcagg agggagcttg tgttcctgtg   4620

acctgtgacc cacctccacc aaaattccat gggctctacc agtgtactaa tggcttccag   4680

ttcaacagtg agtgtaggat caagtgtgaa gacagtgatg cctcccaggg acttgggagc   4740

aatgtcattc attgccggaa agatggcacc tggaacggct ccttccatgt ctgccaggag   4800

atgcaaggcc agtgctcggt tccaaacgag ctcaacagca acctcaaact gcagtgccct   4860

gatggctatg ccatagggtc ggagtgtgcc acctcgtgcc tggaccacaa cagcgagtcc   4920

atcatcctgc caatgaacgt gaccgtgcgt gacatccccc actggctgaa ccccacacgg   4980

gtagagagag ttgtctgcac tgctggtctc aagtggtatc ctcaccctgc tctgattcac   5040

tgtgtcaaag gctgtgagcc cttcatggga gacaattatt gtgatgccat caacaaccga   5100

gccttttgca actatgacgg tggggattgc tgcacctcca cagtgaagac caaaaaggtc   5160

accccattcc ctatgtcctg tgatctacaa ggtgactgtg cttgtcggga cccccaggcc   5220

caagaacaca gccggaaaga cctccgggga tacagccatg gctaaggaag gacaagaagt   5280

tgtcaaagaa ttcccaacgc caggacccac atccctttgg tattgatttc acagtcagct   5340

gctcaacgga atggcctctc cacaccaggg atccttagca cccaaccggt ctgcctttaa   5400

ttttacccag gaaggactca cattggggcg aatgaaccaa gtttcgccat gctggatgat   5460

gaaatggatt cccatcccaa agtctgagat ggattgcata tacagtgtgc agtcccagag   5520

cctcctaaaa ttctagccat ttgtcacaca accacagcaa gaaacgtgtt ctatatctag   5580

agtgtgccca tctgtgttta gtacacatgc atgcatacac acccatacaa acatctgtgt   5640

gagggcagtt ctggagatga gcagagagag accggaataa actcaatctt ttctttccca   5700

agctcctagc caacactatc cttgggagaa agaaatttgc agaaactgct aagaccaagt   5760

gtggagatgt caagctagtt cacactctga ggctcagaat atgtaggaca tgcacaattg   5820

tgcagtcctt tgggattgga agtgaaacag tctgtgatcc cctaccttct agggaactag   5880

gacctaggaa gaggtaaaga ttatcaggta tgcaaagcgc cccaattctt ctgctgccat   5940

gggggatttt accccaactc cagggttcga ggccaatctg agaatggctt aggattgcaa   6000

tgtcaaggta ttatatcagc cccttgcttg aggcttgagg tcataatatc cctctaggac   6060

ttacctgttc ccccagatct tgccttggga ccacatttgc tgctactttt cctgctgctc   6120

tatcctatac attgaataat ccaagatggt agaactaggt taggaaaaat tccacacaac   6180

caaacagtct gccttaaaag tgacccacat ttttccatag ctcctcactt tttagccctt   6240

ctgcaagaga aaaaccctca tgggtccaca tggtgagaag ttaagtttcc tgtaagtggg   6300

cctctcaccc tggaaaggag ttgagggaca tcagatgctg gaaccctcac tgaaagtcca   6360

gaatgtctaa gccagtgtta gattttgtaa acaagtggaa cagtgttaaa tttctatgat   6420

gttggagcca tccagagact actggaattg tcgagacttt tggattatta tccttatcct   6480

tatcctaatc ttcctagccc ttcaggctag agtaggcttc gatcctgaga accttgctgt   6540

tgctctgagg agatataatt ctgggagaaa gaatctttta taagaacagt acagattgtt   6600

ctcaagaggg ccatcagaag gaagccaaag agttcacagc ctcagcacca acaactcaac   6660

atggtcatca tgttttctat atggtttttc cagctagcag tactcccttc catacctgtg   6720

actgggcagt gcttttctct ctcccatgtc tagcctccaa aagttaagtg aaaattagtc   6780

aactgcacgt ggaagccccc accactttgg ggatctcttt atttcttttc agccagggac   6840

ctgtccactc cctttgaatt aatatgggaa gaaattaata caggatgaac tggagagaag   6900

ggttgagtgt ggcatacttt ctgaaacctg gagctgggaa ttgcggagaa gggaaggtct   6960

agactagtta catcacatag ggattactgt aaatcaagtc atctcaagtc tagtgaagac   7020

agccaacaga aacaaaacct agcataggga tagaaaatac catgcacgtg tgcagcccca   7080

cctaattcct gcatccaagg caggtgttgt taatctatca tagcacttaa aaaaaaaaaa   7140

aaaaagagac caaaaataac tttaggaacc accatattat atcactccca atagcactga   7200

cctggtgatc aaaaacactt gagaagacat ctattggcca tctctggcca attacactaa   7260

gaaacatatc aaggtgcttt tggcacaggt gcccacaaat acggatgcag tgctgagata   7320

gtttatgaga cttgtaccat ttcacaaact ctgaaattgg gttccatatt ggcaaggctg   7380

ccacagttgt taagaataat cctctatgtt tcttcctcac aaaaccatat ctcatttata   7440

tccagaccat tacttcacta taattacaag gacaaattat tagcaagaaa taagaatagt   7500

attagaagaa ttgatcctat tttgaacccc tctccagtat cttcacactc ttgtcaactc   7560

tccaggcctc tctcttgccc tgagttatca gcctgtgtgg tgttaactac cttagaaggt   7620

acaagctaag aaatgtaaca gtatcaaccc tcccagttgc ttaattatac ccataggtaa   7680

tacaaaaagc tctgaagacc caaagatgac attactaatg atgtgatttc aggagccaca   7740

gaagaacctt accagcttcc ctcaaatcag tccttatcct ctttctatct tcactcccat   7800

catcatctat tttcacacta tccagctaag caaagattcc tggaggctga cttgtatctt   7860

cagactcaca gagtgaattc agctcttctg aatcaagacc cacccagtct ctttcattca   7920

gacctgttgc taacaaattt atatttgcca aggatattag gcaaaagagg ctacttgatt   7980

ggtggccaac ctcgtgccca catggaaggt atctttaata gggtcttttc aaaccttagt   8040

ggaggagggt cagctcaatt tgggcaatgc atttgttccc agtttcattt tcttcctggg   8100

aattaactcg tcatttcatt ccttcagtca tcttctgtgt aggtgaccgg agcactgaga   8160

ggcagctctg atgcactatt gtgtgtcagc agctcaaagg ccctaaaaca ctgaaggttc   8220

tgcatctgaa gtattagatt gttagcagca aaatatgaaa gatgaggtgg acagtcctct   8280

aagccctatt tagggaagct tttccaagcc acaatcttaa ctacctaccc aaaggatttg   8340

cattaccccc agattctgtg ccaacaacct tttaaggaaa tacagtcctt gggaaatgag   8400

ttttgatggt gaattggggt gttaaggaag ggaaagattg tcatagatgg tagggctttg   8460

aaaatgcagg gtatcagctg ccactcctgg cttcaacaca ttgagtcact gcctagacgg   8520

ttctcttggt cttattccca tcctggccaa tgcttaaata ctatttgttg aaaataattc   8580

tttgagacag atttcagcta cctcccttcc aggttcgatt taacttggtt gtaattgtca   8640

atttgttgtt ataggtctta cctgtgtgaa agaaagaaaa agaaagaaag aaagaaagag   8700

aaaggaaatt ataaggtcaa gttaacagtt ttgaggtttt gtgttttttt ctggaactac   8760

ttcaagtgag aaaataaaaa aaaatggtga caaagctgta cagatagaga taatagaaga   8820

caaagagatt aaaaggaaat aaaaatgcat gattaaaaac taagaataaa aaacctattt   8880

ttatgtttcc taaaggaaat tgtttattct acagcctcag taggtagaca caaacataaa   8940

gatttcccta gaagacatag agtgggattt gataacactg tctgttattt tctgtacatt   9000

gtggtaggtc caggaaatat gacattttcc cccttgatgt gttattgttg ttgttgggtg   9060

gggtgggcat tttgtttatt tgtttggtgg caatcagtgg tagtagggag tgggagggct   9120

tatattggtt tttccagcta ttaaggggac atattgtgtc gttgtgcttt tcacgttata   9180

aaatgtttat atttaccagt acagcactgg gctttataaa gactgcactc agaaccacac   9240

tgcacagtcc agttttttaa aaagctgcta catgacagac aggtaatccc actgagtgag   9300

ttttgagaaa caaatcaaac gaagtaaaca agaaacataa aaaccaaata gcaaatgaat   9360

aaaagcctgt tcttgtaact tattcaactt ttgccaaatt cctaccaatc acttgctttt   9420

taaaagaaat gtataatagc caaaagagaa attatgtccc tgttgtacag aagttagaat   9480

ttttgactcc aggcagcagt ttgctcagtg atcttgaaca agttatccaa ttgcctctac   9540

atttgcatca gtttctctag ctgcaaaatg gggataatac tatataccta cctcacagtg   9600

ggagggcagg agattttgag gccctgaggt tttaggtggg ctgtgagggc caacgcttga   9660

cacaaagtcc atgggttatt attcaagaat gcacaggccc atcggccttt tagaaagaca   9720

agacagggag tgcttgtttg atatttcaag gaataaagcc ggagctcctg aattgtagtc   9780

caccttaaaa gagagacctg tattggagaa tattttattt ttttggcaaa tttgatctta   9840

ccctttacca gttctataat ttggttaaaa gctgattatg tcctacaatg tcaaagtcag   9900

ctaactgtcg tctacttaag acttctggtc atttccaact tatagaggaa gggagtctct   9960

aaaatctctt cttcagaagg cacctcactt ctcagactta aaattccaca tcaagtgttc  10020

cattaaaaga agataaggca ttctgagtgc aaacaaatgg gggcttctta aactacacac  10080

cagcagtcag tgaggaaaac tttgaacaat tattgagttg ctttcttggg tctctataat  10140

caataacctg tctgcagata tctatctata taaagatatt atatataaat ataaatttac  10200

atatatatgc acatgtatat atagttgtac atatatgtgt gtatatatat acttaaatgt  10260

aatatttaca aaataaaact gtgatctcgt ctagagaaaa tgtattcata ttacaaactg  10320

ctcttccata tttatgtacc atattatacc tttttattat tgttataatt attatgggta  10380

tttctaatta atatgatgtt gaaacctgtt tggcaccttc tggaagctac caaaaaaatg  10440

acactccatt gaagtgctta aaagctgttc tcataagaat tctactggcc tattgtaaaa  10500

aagaaaaaaa aaaagaaaaa gaagaaagac acaaagaaaa taatctaaac accaaaaact  10560

aaacacaatt ccaatccttt ttctgtacct cacgcgcata aatttgctgc tcctattttt  10620

ttttctgttt atgtgttttt atggatctaa gttaaatctt ttggcaatat ataaaaatgt  10680

aaatagtaaa ctttatttat taagaatgtc atctttttta atttatattt acacaattgt  10740

tcatctaatt tattttttct atacagtttt aaatactcag acatattttg ctgttcatga  10800

tatttttatc ctgttctcat ggatttgttt tcccatactg ttttctctga tctcaattac  10860

aggttggatc tcacaaataa taatgtcaga gacagaaata ttttgccact gttgattact  10920

atactttaaa gttctatatt atgaaaatat ataatagctt gtacgcttca aaaaaaaaaa  10980

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                  11025


<210>  648
<211>  1627
<212>  PRT
<213>  Homo sapiens

<400>  648

Met Arg Leu Trp Ser Trp Val Leu His Leu Gly Leu Leu Ser Ala Ala 
1               5                   10                  15


Leu Gly Cys Gly Leu Ala Glu Arg Pro Arg Arg Ala Arg Arg Asp Pro 
            20                  25                  30


Arg Ala Gly Arg Pro Pro Arg Pro Ala Ala Gly Pro Ala Thr Cys Ala 
        35                  40                  45


Thr Arg Ala Ala Arg Gly Arg Arg Ala Ser Pro Pro Pro Pro Pro Pro 
    50                  55                  60


Pro Gly Gly Ala Trp Glu Ala Val Arg Val Pro Arg Arg Arg Gln Gln 
65                  70                  75                  80


Arg Glu Ala Arg Gly Ala Thr Glu Glu Pro Ser Pro Pro Ser Arg Ala 
                85                  90                  95


Leu Tyr Phe Ser Gly Arg Gly Glu Gln Leu Arg Leu Arg Ala Asp Leu 
            100                 105                 110


Glu Leu Pro Arg Asp Ala Phe Thr Leu Gln Val Trp Leu Arg Ala Glu 
        115                 120                 125


Gly Gly Gln Arg Ser Pro Ala Val Ile Thr Gly Leu Tyr Asp Lys Cys 
    130                 135                 140


Ser Tyr Ile Ser Arg Asp Arg Gly Trp Val Val Gly Ile His Thr Ile 
145                 150                 155                 160


Ser Asp Gln Asp Asn Lys Asp Pro Arg Tyr Phe Phe Ser Leu Lys Thr 
                165                 170                 175


Asp Arg Ala Arg Gln Val Thr Thr Ile Asn Ala His Arg Ser Tyr Leu 
            180                 185                 190


Pro Gly Gln Trp Val Tyr Leu Ala Ala Thr Tyr Asp Gly Gln Phe Met 
        195                 200                 205


Lys Leu Tyr Val Asn Gly Ala Gln Val Ala Thr Ser Gly Glu Gln Val 
    210                 215                 220


Gly Gly Ile Phe Ser Pro Leu Thr Gln Lys Cys Lys Val Leu Met Leu 
225                 230                 235                 240


Gly Gly Ser Ala Leu Asn His Asn Tyr Arg Gly Tyr Ile Glu His Phe 
                245                 250                 255


Ser Leu Trp Lys Val Ala Arg Thr Gln Arg Glu Ile Leu Ser Asp Met 
            260                 265                 270


Glu Thr His Gly Ala His Thr Ala Leu Pro Gln Leu Leu Leu Gln Glu 
        275                 280                 285


Asn Trp Asp Asn Val Lys His Ala Trp Ser Pro Met Lys Asp Gly Ser 
    290                 295                 300


Ser Pro Lys Val Glu Phe Ser Asn Ala His Gly Phe Leu Leu Asp Thr 
305                 310                 315                 320


Ser Leu Glu Pro Pro Leu Cys Gly Gln Thr Leu Cys Asp Asn Thr Glu 
                325                 330                 335


Val Ile Ala Ser Tyr Asn Gln Leu Ser Ser Phe Arg Gln Pro Lys Val 
            340                 345                 350


Val Arg Tyr Arg Val Val Asn Leu Tyr Glu Asp Asp His Lys Asn Pro 
        355                 360                 365


Thr Val Thr Arg Glu Gln Val Asp Phe Gln His His Gln Leu Ala Glu 
    370                 375                 380


Ala Phe Lys Gln Tyr Asn Ile Ser Trp Glu Leu Asp Val Leu Glu Val 
385                 390                 395                 400


Ser Asn Ser Ser Leu Arg Arg Arg Leu Ile Leu Ala Asn Cys Asp Ile 
                405                 410                 415


Ser Lys Ile Gly Asp Glu Asn Cys Asp Pro Glu Cys Asn His Thr Leu 
            420                 425                 430


Thr Gly His Asp Gly Gly Asp Cys Arg His Leu Arg His Pro Ala Phe 
        435                 440                 445


Val Lys Lys Gln His Asn Gly Val Cys Asp Met Asp Cys Asn Tyr Glu 
    450                 455                 460


Arg Phe Asn Phe Asp Gly Gly Glu Cys Cys Asp Pro Glu Ile Thr Asn 
465                 470                 475                 480


Val Thr Gln Thr Cys Phe Asp Pro Asp Ser Pro His Arg Ala Tyr Leu 
                485                 490                 495


Asp Val Asn Glu Leu Lys Asn Ile Leu Lys Leu Asp Gly Ser Thr His 
            500                 505                 510


Leu Asn Ile Phe Phe Ala Lys Ser Ser Glu Glu Glu Leu Ala Gly Val 
        515                 520                 525


Ala Thr Trp Pro Trp Asp Lys Glu Ala Leu Met His Leu Gly Gly Ile 
    530                 535                 540


Val Leu Asn Pro Ser Phe Tyr Gly Met Pro Gly His Thr His Thr Met 
545                 550                 555                 560


Ile His Glu Ile Gly His Ser Leu Gly Leu Tyr His Val Phe Arg Gly 
                565                 570                 575


Ile Ser Glu Ile Gln Ser Cys Ser Asp Pro Cys Met Glu Thr Glu Pro 
            580                 585                 590


Ser Phe Glu Thr Gly Asp Leu Cys Asn Asp Thr Asn Pro Ala Pro Lys 
        595                 600                 605


His Lys Ser Cys Gly Asp Pro Gly Pro Gly Asn Asp Thr Cys Gly Phe 
    610                 615                 620


His Ser Phe Phe Asn Thr Pro Tyr Asn Asn Phe Met Ser Tyr Ala Asp 
625                 630                 635                 640


Asp Asp Cys Thr Asp Ser Phe Thr Pro Asn Gln Val Ala Arg Met His 
                645                 650                 655


Cys Tyr Leu Asp Leu Val Tyr Gln Gly Trp Gln Pro Ser Arg Lys Pro 
            660                 665                 670


Ala Pro Val Ala Leu Ala Pro Gln Val Leu Gly His Thr Thr Asp Ser 
        675                 680                 685


Val Thr Leu Glu Trp Phe Pro Pro Ile Asp Gly His Phe Phe Glu Arg 
    690                 695                 700


Glu Leu Gly Ser Ala Cys His Leu Cys Leu Glu Gly Arg Ile Leu Val 
705                 710                 715                 720


Gln Tyr Ala Ser Asn Ala Ser Ser Pro Met Pro Cys Ser Pro Ser Gly 
                725                 730                 735


His Trp Ser Pro Arg Glu Ala Glu Gly His Pro Asp Val Glu Gln Pro 
            740                 745                 750


Cys Lys Ser Ser Val Arg Thr Trp Ser Pro Asn Ser Ala Val Asn Pro 
        755                 760                 765


His Thr Val Pro Pro Ala Cys Pro Glu Pro Gln Gly Cys Tyr Leu Glu 
    770                 775                 780


Leu Glu Phe Leu Tyr Pro Leu Val Pro Glu Ser Leu Thr Ile Trp Val 
785                 790                 795                 800


Thr Phe Val Ser Thr Asp Trp Asp Ser Ser Gly Ala Val Asn Asp Ile 
                805                 810                 815


Lys Leu Leu Ala Val Ser Gly Lys Asn Ile Ser Leu Gly Pro Gln Asn 
            820                 825                 830


Val Phe Cys Asp Val Pro Leu Thr Ile Arg Leu Trp Asp Val Gly Glu 
        835                 840                 845


Glu Val Tyr Gly Ile Gln Ile Tyr Thr Leu Asp Glu His Leu Glu Ile 
    850                 855                 860


Asp Ala Ala Met Leu Thr Ser Thr Ala Asp Thr Pro Leu Cys Leu Gln 
865                 870                 875                 880


Cys Lys Pro Leu Lys Tyr Lys Val Val Arg Asp Pro Pro Leu Gln Met 
                885                 890                 895


Asp Val Ala Ser Ile Leu His Leu Asn Arg Lys Phe Val Asp Met Asp 
            900                 905                 910


Leu Asn Leu Gly Ser Val Tyr Gln Tyr Trp Val Ile Thr Ile Ser Gly 
        915                 920                 925


Thr Glu Glu Ser Glu Pro Ser Pro Ala Val Thr Tyr Ile His Gly Ser 
    930                 935                 940


Gly Tyr Cys Gly Asp Gly Ile Ile Gln Lys Asp Gln Gly Glu Gln Cys 
945                 950                 955                 960


Asp Asp Met Asn Lys Ile Asn Gly Asp Gly Cys Ser Leu Phe Cys Arg 
                965                 970                 975


Gln Glu Val Ser Phe Asn Cys Ile Asp Glu Pro Ser Arg Cys Tyr Phe 
            980                 985                 990


His Asp Gly Asp Gly Val Cys Glu Glu Phe Glu Gln Lys Thr Ser Ile 
        995                 1000                1005


Lys Asp Cys Gly Val Tyr Thr Pro Gln Gly Phe Leu Asp Gln Trp Ala 
    1010                1015                1020


Ser Asn Ala Ser Val Ser His Gln Asp Gln Gln Cys Pro Gly Trp Val 
1025                1030                1035                1040


Ile Ile Gly Gln Pro Ala Ala Ser Gln Val Cys Arg Thr Lys Val Ile 
                1045                1050                1055


Asp Leu Ser Glu Gly Ile Ser Gln His Ala Trp Tyr Pro Cys Thr Ile 
            1060                1065                1070


Ser Tyr Pro Tyr Ser Gln Leu Ala Gln Thr Thr Phe Trp Leu Arg Ala 
        1075                1080                1085


Tyr Phe Ser Gln Pro Met Val Ala Ala Ala Val Ile Val His Leu Val 
    1090                1095                1100


Thr Asp Gly Thr Tyr Tyr Gly Asp Gln Lys Gln Glu Thr Ile Ser Val 
1105                1110                1115                1120


Gln Leu Leu Asp Thr Lys Asp Gln Ser His Asp Leu Gly Leu His Val 
                1125                1130                1135


Leu Ser Cys Arg Asn Asn Pro Leu Ile Ile Pro Val Val His Asp Leu 
            1140                1145                1150


Ser Gln Pro Phe Tyr His Ser Gln Ala Val Arg Val Ser Phe Ser Ser 
        1155                1160                1165


Pro Leu Val Ala Ile Ser Gly Val Ala Leu Arg Ser Phe Asp Asn Phe 
    1170                1175                1180


Asp Pro Val Thr Leu Ser Ser Cys Gln Arg Gly Glu Thr Tyr Ser Pro 
1185                1190                1195                1200


Ala Glu Gln Ser Cys Val His Phe Ala Cys Glu Lys Thr Asp Cys Pro 
                1205                1210                1215


Glu Leu Ala Val Glu Asn Ala Ser Leu Asn Cys Ser Ser Ser Asp Arg 
            1220                1225                1230


Tyr His Gly Ala Gln Cys Thr Val Ser Cys Arg Thr Gly Tyr Val Leu 
        1235                1240                1245


Gln Ile Arg Arg Asp Asp Glu Leu Ile Lys Ser Gln Thr Gly Pro Ser 
    1250                1255                1260


Val Thr Val Thr Cys Thr Glu Gly Lys Trp Asn Lys Gln Val Ala Cys 
1265                1270                1275                1280


Glu Pro Val Asp Cys Ser Ile Pro Asp His His Gln Val Tyr Ala Ala 
                1285                1290                1295


Ser Phe Ser Cys Pro Glu Gly Thr Thr Phe Gly Ser Gln Cys Ser Phe 
            1300                1305                1310


Gln Cys Arg His Pro Ala Gln Leu Lys Gly Asn Asn Ser Leu Leu Thr 
        1315                1320                1325


Cys Met Glu Asp Gly Leu Trp Ser Phe Pro Glu Ala Leu Cys Glu Leu 
    1330                1335                1340


Met Cys Leu Ala Pro Pro Pro Val Pro Asn Ala Asp Leu Gln Thr Ala 
1345                1350                1355                1360


Arg Cys Arg Glu Asn Lys His Lys Val Gly Ser Phe Cys Lys Tyr Lys 
                1365                1370                1375


Cys Lys Pro Gly Tyr His Val Pro Gly Ser Ser Arg Lys Ser Lys Lys 
            1380                1385                1390


Arg Ala Phe Lys Thr Gln Cys Thr Gln Asp Gly Ser Trp Gln Glu Gly 
        1395                1400                1405


Ala Cys Val Pro Val Thr Cys Asp Pro Pro Pro Pro Lys Phe His Gly 
    1410                1415                1420


Leu Tyr Gln Cys Thr Asn Gly Phe Gln Phe Asn Ser Glu Cys Arg Ile 
1425                1430                1435                1440


Lys Cys Glu Asp Ser Asp Ala Ser Gln Gly Leu Gly Ser Asn Val Ile 
                1445                1450                1455


His Cys Arg Lys Asp Gly Thr Trp Asn Gly Ser Phe His Val Cys Gln 
            1460                1465                1470


Glu Met Gln Gly Gln Cys Ser Val Pro Asn Glu Leu Asn Ser Asn Leu 
        1475                1480                1485


Lys Leu Gln Cys Pro Asp Gly Tyr Ala Ile Gly Ser Glu Cys Ala Thr 
    1490                1495                1500


Ser Cys Leu Asp His Asn Ser Glu Ser Ile Ile Leu Pro Met Asn Val 
1505                1510                1515                1520


Thr Val Arg Asp Ile Pro His Trp Leu Asn Pro Thr Arg Val Glu Arg 
                1525                1530                1535


Val Val Cys Thr Ala Gly Leu Lys Trp Tyr Pro His Pro Ala Leu Ile 
            1540                1545                1550


His Cys Val Lys Gly Cys Glu Pro Phe Met Gly Asp Asn Tyr Cys Asp 
        1555                1560                1565


Ala Ile Asn Asn Arg Ala Phe Cys Asn Tyr Asp Gly Gly Asp Cys Cys 
    1570                1575                1580


Thr Ser Thr Val Lys Thr Lys Lys Val Thr Pro Phe Pro Met Ser Cys 
1585                1590                1595                1600


Asp Leu Gln Gly Asp Cys Ala Cys Arg Asp Pro Gln Ala Gln Glu His 
                1605                1610                1615


Ser Arg Lys Asp Leu Arg Gly Tyr Ser His Gly 
            1620                1625


<210>  649
<211>  5041
<212>  DNA
<213>  Homo sapiens

<400>  649
cgcgcgccgg gcacgcgcgc cggcgaccat ggcgttcgcc gggctggagc gagtacatta     60

acccctggag gcggcggcgg cggcgaggga gcgagcctcg agcgggcggg ccccagcctg    120

agggaaggga ggaaggggcg gggagagcgc cagagggagg ccggtcggcc gcgggcgggc    180

gggcagcgca gcgccgagcg gggcccgcgg gcccatgagg aggcctgggg accatgggct    240

ccaggatcaa gcagaatcca gagaccacat ttgaagtata tgttgaagtg gcctatccca    300

ggacaggtgg cactctttca gatcctgagg tgcagaggca attcccggag gactacagtg    360

accaggaagt tctacagact ttgaccaagt tttgtttccc cttctatgtg gacagcctca    420

cagttagcca agttggccag aacttcacat tcgtgctcac tgacattgac agcaaacaga    480

gattcgggtt ctgccgctta tcttcaggag cgaagagctg cttctgtatc ttaagctatc    540

tcccctggtt cgaggtattt tataagctgc ttaacatcct ggcagattac acgacaaaaa    600

gacaggaaaa tcagtggaat gagcttcttg aaactctgca caaacttccc atccctgacc    660

caggagtgtc tgtccatctc agcgtgcatt cttattttac tgtgcctgat accagagaac    720

ttcccagcat acctgagaat agaaatctga cagaatattt tgtggctgtg gatgttaaca    780

acatgttgca tctgtacgcc agtatgctgt acgaacgccg gatactcatc atttgcagca    840

aactcagcac tctgactgcc tgcatccacg ggtctgcggc gatgctctac cccatgtact    900

ggcagcacgt gtacatcccc gtgctgccgc cgcatctgct ggactactgc tgtgctccca    960

tgccctacct cataggaatc catttaagtt taatggagaa agtcagaaac atggccctgg   1020

atgatgtcgt gatcctgaat gtggacacca acaccctgga aacccccttc gatgacctcc   1080

agagcctccc aaacgacgtg atctcttccc tgaagaacag gctgaaaaag gtctccacaa   1140

ccactgggga tggtgtggcc agagcgttcc tcaaggccca ggctgctttc ttcggtagct   1200

accgaaacgc tctgaaaatc gagccggagg agccgatcac tttctgtgag gaagccttcg   1260

tgtcccacta ccgctccgga gccatgaggc agttcctgca gaacgccaca cagctgcagc   1320

tcttcaagca gtttattgat ggtcgattag atcttctcaa ttccggcgaa ggtttcagtg   1380

atgtttttga agaggaaatc aacatgggcg agtacgctgg cagtgacaaa ctgtaccatc   1440

agtggctctc cactgtccgg aaaggaagtg gagcaattct gaatactgta aagaccaaag   1500

caaatccggc catgaagact gtctacaagt tcgcaaaaga tcatgcaaaa atgggaataa   1560

aagaggtgaa aaaccgcttg aagcaaaagg acattgccga gaatggctgc gcccccaccc   1620

cagaagagca gctgccaaag actgcaccgt ccccactggt ggaggccaag gaccccaagc   1680

tccgagaaga ccggcggcca atcacagtcc actttggaca ggtgcgccca cctcgtccac   1740

atgttgttaa gagaccaaag agcaacatcg cagtggaagg ccggaggacg tctgtgccga   1800

gccctgagca gccgcagccg tatcggacac tcagggagtc agacagcgcg gaaggcgacg   1860

aggcagagag tccagagcag caagtgcgga agtccacagg ccctgtccca gctccccctg   1920

accgggctgc cagcatcgac cttctggaag acgtcttcag caacctggac atggaggccg   1980

cactgcagcc actgggccag gccaagagct tagaggacct tcgtgccccc aaagacctga   2040

gggagcagcc agggaccttt gactatcaga ggctggatct gggcgggagt gagaggagcc   2100

gcggggtgac agtggccttg aagcttaccc acccgtacaa caagctctgg agcctgggcc   2160

aggacgacat ggccatcccc agcaagcccc cagctgcctc ccctgagaag ccctcggccc   2220

tgctcgggaa ctccctggcc ctgcctcgaa ggccccagaa ccgggacagc atcctgaacc   2280

ccagtgacaa ggaggaggtg cccaccccta ctctgggcag catcaccatc ccccggcccc   2340

aaggcaggaa gaccccagag ctgggcatcg tgcctccacc gcccattccc cgcccggcca   2400

agctccaggc tgccggcgcc gcacttggtg acgtctcaga gcggctgcag acggatcggg   2460

acaggcgagc tgccctgagt ccagggctcc tgcctggtgt tgtcccccaa ggccccactg   2520

aactgctcca gccgctcagc cctggccccg gggctgcagg cacgagcagt gacgccctgc   2580

tcgccctcct ggacccgctc agcacagcct ggtcaggcag caccctcccg tcacgccccg   2640

ccaccccgaa tgtagccacc ccattcaccc cccaattcag cttcccccct gcagggacac   2700

ccaccccatt cccacagcca ccactcaacc cctttgtccc atccatgcca gcagccccac   2760

ccaccctgcc cctggtctcc acaccagccg ggcctttcgg ggcccctcca gcttccctgg   2820

ggccggcttt tgcgtccggc ctcctgctgt ccagtgctgg cttctgtgcc cctcacaggt   2880

ctcagcccaa cctctccgcc ctctccatgc ccaacctctt tggccagatg cccatgggca   2940

cccacacgag ccccctacag ccgctgggtc ccccagcagt tgccccgtcg aggatccgaa   3000

cgttgcccct ggcccgctca agtgccaggg ctgctgagac caagcagggg ctggccctga   3060

ggcctggaga ccccccgctt ctgcctccca ggccccctca aggcctggag ccaacactgc   3120

agccctctgc tcctcaacag gccagagacc cctttgagga tttgttacag aaaaccaagc   3180

aagacgtgag cccgagtccg gccctggccc cggccccaga ctcggtggag cagctcagga   3240

agcagtggga gaccttcgag tgagccgggc cctgagggtg ggggatgcac cgaggcccga   3300

gggtccgtcc actgctgcgg ttccgaggct cccccgccac tctctctctg cccaggttct   3360

gctggtggga agggatggga cccctctctg ctgccccctc ctcccctcca cactgcccat   3420

ctctgatgtc tggccctggg gaatggcacc agttccagcc tgggaatcaa cccagttcct   3480

gagtgcccat cccaccccgc ggttgcctct cctcggcacc cttgattggg ttttgcacta   3540

aagaggtcag ctgggccaat gatattgctc cagaccgagt cctacccacc ttcccccgga   3600

agtgtcccaa gaggctccga aggcctcccc tccgagccca gctctcctgt ctcctccaca   3660

gccaggccct gcacgcccac ctcctcggac acaggtgaca gggttaccct ccagtttgag   3720

ctcatctgca cgagacacag gtagcttggg gttgaagtta ggactcctcc tgggctggag   3780

gatttacctg gtggggcact tccagactgt ttctagcaat atacacacac gttctttcct   3840

gtgtcttcac cccaaaactt cagttgattc tgacctggga ggatctgggg accagggggt   3900

cttgggctgc cttgtgatac acagccccag ccaccctgca cgggggctgc gagcaccagc   3960

aactttgatt tatagaagga aaatggaaac ccccatctga gtattttggg aggagccccc   4020

agccctcatc cagctctggc acgctgatac ctccaggtac tcccctcact gtcaaagctg   4080

gggctcagcc tcttgtcatc tggagctttg tgggcaaagc tgagaagctg caacccagat   4140

ttcaacccaa aaaggtcaag ctgaatgcct cagactgatg tggaaggcag ctggccttcc   4200

tgggttggaa cgaggcagtg gccctgagcc ccttctccag ggccaggtag aaaggacaaa   4260

cttggtctct gcctcgggga agcaggagga gggctagaag ccagtccctc cccacctgcc   4320

cagagctcca ggccagcaca gaaattcctg aggccaacgt caccaaagtt agattgaatg   4380

tttattatct ttctttttcc tttttacctt attgatttga tgaatcttga aatggattca   4440

tttccataaa ccaagttaaa gtatggcccg accatttaag aaaacaacca tctgagacac   4500

gcaggaaatt gtgagcattt cgacccgagc tctcatttcc tatttgtgaa gggtcagaca   4560

cagtctaccc aggggtgtct gggggacaag ggggtctctg gagatgtcac ccagggagcc   4620

ccctctatgt ctgagaggct gccactgctg cacatgctca gtgaggcttg gcggccatcc   4680

tggcacatgg ctcttcctgg gtcaaccgtg acctgtctgg ctcaggaatg ggctctggct   4740

gctgggggag ccgtgtcact cctgggccat gggggcacct cctgggcact taggtgtttc   4800

agcatagatt ccagtttcgc accctgggca gacccccagg ccccatccgg gatagggcag   4860

aggaggtgct ggcggcccca gggaaggagg gtgtgtaccc caaggccccc tggctgtgct   4920

gaggggctgg ggtgagcgct ccatgttcac atgagcactg ctgcctcttc acttgtggga   4980

ctttttgcaa acccaaggat gaactttgtg tgcattcaat aaaatcatct tggggaagag   5040

g                                                                   5041


<210>  650
<211>  1009
<212>  PRT
<213>  Homo sapiens

<400>  650

Met Gly Ser Arg Ile Lys Gln Asn Pro Glu Thr Thr Phe Glu Val Tyr 
1               5                   10                  15


Val Glu Val Ala Tyr Pro Arg Thr Gly Gly Thr Leu Ser Asp Pro Glu 
            20                  25                  30


Val Gln Arg Gln Phe Pro Glu Asp Tyr Ser Asp Gln Glu Val Leu Gln 
        35                  40                  45


Thr Leu Thr Lys Phe Cys Phe Pro Phe Tyr Val Asp Ser Leu Thr Val 
    50                  55                  60


Ser Gln Val Gly Gln Asn Phe Thr Phe Val Leu Thr Asp Ile Asp Ser 
65                  70                  75                  80


Lys Gln Arg Phe Gly Phe Cys Arg Leu Ser Ser Gly Ala Lys Ser Cys 
                85                  90                  95


Phe Cys Ile Leu Ser Tyr Leu Pro Trp Phe Glu Val Phe Tyr Lys Leu 
            100                 105                 110


Leu Asn Ile Leu Ala Asp Tyr Thr Thr Lys Arg Gln Glu Asn Gln Trp 
        115                 120                 125


Asn Glu Leu Leu Glu Thr Leu His Lys Leu Pro Ile Pro Asp Pro Gly 
    130                 135                 140


Val Ser Val His Leu Ser Val His Ser Tyr Phe Thr Val Pro Asp Thr 
145                 150                 155                 160


Arg Glu Leu Pro Ser Ile Pro Glu Asn Arg Asn Leu Thr Glu Tyr Phe 
                165                 170                 175


Val Ala Val Asp Val Asn Asn Met Leu His Leu Tyr Ala Ser Met Leu 
            180                 185                 190


Tyr Glu Arg Arg Ile Leu Ile Ile Cys Ser Lys Leu Ser Thr Leu Thr 
        195                 200                 205


Ala Cys Ile His Gly Ser Ala Ala Met Leu Tyr Pro Met Tyr Trp Gln 
    210                 215                 220


His Val Tyr Ile Pro Val Leu Pro Pro His Leu Leu Asp Tyr Cys Cys 
225                 230                 235                 240


Ala Pro Met Pro Tyr Leu Ile Gly Ile His Leu Ser Leu Met Glu Lys 
                245                 250                 255


Val Arg Asn Met Ala Leu Asp Asp Val Val Ile Leu Asn Val Asp Thr 
            260                 265                 270


Asn Thr Leu Glu Thr Pro Phe Asp Asp Leu Gln Ser Leu Pro Asn Asp 
        275                 280                 285


Val Ile Ser Ser Leu Lys Asn Arg Leu Lys Lys Val Ser Thr Thr Thr 
    290                 295                 300


Gly Asp Gly Val Ala Arg Ala Phe Leu Lys Ala Gln Ala Ala Phe Phe 
305                 310                 315                 320


Gly Ser Tyr Arg Asn Ala Leu Lys Ile Glu Pro Glu Glu Pro Ile Thr 
                325                 330                 335


Phe Cys Glu Glu Ala Phe Val Ser His Tyr Arg Ser Gly Ala Met Arg 
            340                 345                 350


Gln Phe Leu Gln Asn Ala Thr Gln Leu Gln Leu Phe Lys Gln Phe Ile 
        355                 360                 365


Asp Gly Arg Leu Asp Leu Leu Asn Ser Gly Glu Gly Phe Ser Asp Val 
    370                 375                 380


Phe Glu Glu Glu Ile Asn Met Gly Glu Tyr Ala Gly Ser Asp Lys Leu 
385                 390                 395                 400


Tyr His Gln Trp Leu Ser Thr Val Arg Lys Gly Ser Gly Ala Ile Leu 
                405                 410                 415


Asn Thr Val Lys Thr Lys Ala Asn Pro Ala Met Lys Thr Val Tyr Lys 
            420                 425                 430


Phe Ala Lys Asp His Ala Lys Met Gly Ile Lys Glu Val Lys Asn Arg 
        435                 440                 445


Leu Lys Gln Lys Asp Ile Ala Glu Asn Gly Cys Ala Pro Thr Pro Glu 
    450                 455                 460


Glu Gln Leu Pro Lys Thr Ala Pro Ser Pro Leu Val Glu Ala Lys Asp 
465                 470                 475                 480


Pro Lys Leu Arg Glu Asp Arg Arg Pro Ile Thr Val His Phe Gly Gln 
                485                 490                 495


Val Arg Pro Pro Arg Pro His Val Val Lys Arg Pro Lys Ser Asn Ile 
            500                 505                 510


Ala Val Glu Gly Arg Arg Thr Ser Val Pro Ser Pro Glu Gln Pro Gln 
        515                 520                 525


Pro Tyr Arg Thr Leu Arg Glu Ser Asp Ser Ala Glu Gly Asp Glu Ala 
    530                 535                 540


Glu Ser Pro Glu Gln Gln Val Arg Lys Ser Thr Gly Pro Val Pro Ala 
545                 550                 555                 560


Pro Pro Asp Arg Ala Ala Ser Ile Asp Leu Leu Glu Asp Val Phe Ser 
                565                 570                 575


Asn Leu Asp Met Glu Ala Ala Leu Gln Pro Leu Gly Gln Ala Lys Ser 
            580                 585                 590


Leu Glu Asp Leu Arg Ala Pro Lys Asp Leu Arg Glu Gln Pro Gly Thr 
        595                 600                 605


Phe Asp Tyr Gln Arg Leu Asp Leu Gly Gly Ser Glu Arg Ser Arg Gly 
    610                 615                 620


Val Thr Val Ala Leu Lys Leu Thr His Pro Tyr Asn Lys Leu Trp Ser 
625                 630                 635                 640


Leu Gly Gln Asp Asp Met Ala Ile Pro Ser Lys Pro Pro Ala Ala Ser 
                645                 650                 655


Pro Glu Lys Pro Ser Ala Leu Leu Gly Asn Ser Leu Ala Leu Pro Arg 
            660                 665                 670


Arg Pro Gln Asn Arg Asp Ser Ile Leu Asn Pro Ser Asp Lys Glu Glu 
        675                 680                 685


Val Pro Thr Pro Thr Leu Gly Ser Ile Thr Ile Pro Arg Pro Gln Gly 
    690                 695                 700


Arg Lys Thr Pro Glu Leu Gly Ile Val Pro Pro Pro Pro Ile Pro Arg 
705                 710                 715                 720


Pro Ala Lys Leu Gln Ala Ala Gly Ala Ala Leu Gly Asp Val Ser Glu 
                725                 730                 735


Arg Leu Gln Thr Asp Arg Asp Arg Arg Ala Ala Leu Ser Pro Gly Leu 
            740                 745                 750


Leu Pro Gly Val Val Pro Gln Gly Pro Thr Glu Leu Leu Gln Pro Leu 
        755                 760                 765


Ser Pro Gly Pro Gly Ala Ala Gly Thr Ser Ser Asp Ala Leu Leu Ala 
    770                 775                 780


Leu Leu Asp Pro Leu Ser Thr Ala Trp Ser Gly Ser Thr Leu Pro Ser 
785                 790                 795                 800


Arg Pro Ala Thr Pro Asn Val Ala Thr Pro Phe Thr Pro Gln Phe Ser 
                805                 810                 815


Phe Pro Pro Ala Gly Thr Pro Thr Pro Phe Pro Gln Pro Pro Leu Asn 
            820                 825                 830


Pro Phe Val Pro Ser Met Pro Ala Ala Pro Pro Thr Leu Pro Leu Val 
        835                 840                 845


Ser Thr Pro Ala Gly Pro Phe Gly Ala Pro Pro Ala Ser Leu Gly Pro 
    850                 855                 860


Ala Phe Ala Ser Gly Leu Leu Leu Ser Ser Ala Gly Phe Cys Ala Pro 
865                 870                 875                 880


His Arg Ser Gln Pro Asn Leu Ser Ala Leu Ser Met Pro Asn Leu Phe 
                885                 890                 895


Gly Gln Met Pro Met Gly Thr His Thr Ser Pro Leu Gln Pro Leu Gly 
            900                 905                 910


Pro Pro Ala Val Ala Pro Ser Arg Ile Arg Thr Leu Pro Leu Ala Arg 
        915                 920                 925


Ser Ser Ala Arg Ala Ala Glu Thr Lys Gln Gly Leu Ala Leu Arg Pro 
    930                 935                 940


Gly Asp Pro Pro Leu Leu Pro Pro Arg Pro Pro Gln Gly Leu Glu Pro 
945                 950                 955                 960


Thr Leu Gln Pro Ser Ala Pro Gln Gln Ala Arg Asp Pro Phe Glu Asp 
                965                 970                 975


Leu Leu Gln Lys Thr Lys Gln Asp Val Ser Pro Ser Pro Ala Leu Ala 
            980                 985                 990


Pro Ala Pro Asp Ser Val Glu Gln Leu Arg Lys Gln Trp Glu Thr Phe 
        995                 1000                1005


Glu 



<210>  651
<211>  2166
<212>  DNA
<213>  Homo sapiens

<400>  651
cgcgcgccgg gcacgcgcgc cggcgaccat ggcgttcgcc gggctggagc gagtacatta     60

acccctggag gcggcggcgg cggcgaggga gcgagcctcg agcgggcggg ccccagcctg    120

agggaaggga ggaaggggcg gggagagcgc cagagggagg ccggtcggcc gcgggcgggc    180

gggcagcgca gcgccgagcg gggcccgcgg gcccatgagg aggcctgggg accatgggct    240

ccaggatcaa gcagaatcca gagaccacat ttgaagtata tgttgaagtg gcctatccca    300

ggacaggtgg cactctttca gatcctgagg tgcagaggca attcccggag gactacagtg    360

accaggaagt tctacagact ttgaccaagt tttgtttccc cttctatgtg gacagcctca    420

cagttagcca agttggccag aacttcacat tcgtgctcac tgacattgac agcaaacaga    480

gattcgggtt ctgccgctta tcttcaggag cgaagagctg cttctgtatc ttaagctatc    540

tcccctggtt cgaggtattt tataagctgc ttaacatcct ggcagattac acgacaaaaa    600

gacaggaaaa tcagtggaat gagcttcttg aaactctgca caaacttccc atccctgacc    660

caggagtgtc tgtccatctc agcgtgcatt cttattttac tgtgcctgat accagagaac    720

ttcccagcat acctgagaat agaaatctga cagaatattt tgtggctgtg gatgttaaca    780

acatgttgca tctgtacgcc agtatgctgt acgaacgccg gatactcatc atttgcagca    840

aactcagcac tctgactgcc tgcatccacg ggtctgcggc gatgctctac cccatgtact    900

ggcagcacgt gtacatcccc gtgctgccgc cgcatctgct ggactactgc tgtgctccca    960

tgccctacct cataggaatc catttaagtt taatggagaa agtcagaaac atggccctgg   1020

atgatgtcgt gatcctgaat gtggacacca acaccctgga aacccccttc gatgacctcc   1080

agagcctccc aaacgacgtg atctcttccc tgaagaacag gctgaaaaag gtctccacaa   1140

ccactgggga tggtgtggcc agagcgttcc tcaaggccca ggctgctttc ttcggtagct   1200

accgaaacgc tctgaaaatc gagccggagg agccgatcac tttctgtgag gaagccttcg   1260

tgtcccacta ccgctccgga gccatgaggc agttcctgca gaacgccaca cagctgcagc   1320

tcttcaagca gtttattgat ggtcgattag atcttctcaa ttccggcgaa ggtttcagtg   1380

atgtttttga agaggaaatc aacatgggcg agtacgctgg cagtgacaaa ctgtaccatc   1440

agtggctctc cactgtccgg aaaggaagtg gagcaattct gaatactgta aagaccaaag   1500

caaatccggc catgaagact gtctacaagt tcgcaaaaga tcatgcaaaa atgggaataa   1560

aagaggtgaa aaaccgcttg aagcaaaagg acattgccga gaatggctgc gcccccaccc   1620

cagaagagca gctgccaaag actgcaccgt ccccactggt ggaggccaag gaccccaagc   1680

tccgagaaga ccggcggcca atcacagtcc actttggaca ggtgcgccca cctcgtccac   1740

atgttgttaa gagaccaaag agcaacatcg cagtggaagg ccggaggacg tctgtgccga   1800

gccctgagca aaacaccatt gcaacaccag ctacactcca catcctacag aaaagcatta   1860

cccattttgc ggccaagttc ccgacgagag gctggacctc ttcatcacat tgacttacgc   1920

cgttgctttt ccagactggg cagaggggct gacttcgcag tgtgtgccaa agagccggtg   1980

tctgataatc ccattttcct gcttatcacc tgaactgtgt cagtatcact tttagttttg   2040

ttggttggtt ggtttgttgt ttgtttaata tgccctgttt tctacttctg ttggaaaata   2100

tttggggttg aaataaacca gtgggagcat ggaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2160

aaaaaa                                                              2166


<210>  652
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  652

Met Gly Ser Arg Ile Lys Gln Asn Pro Glu Thr Thr Phe Glu Val Tyr 
1               5                   10                  15


Val Glu Val Ala Tyr Pro Arg Thr Gly Gly Thr Leu Ser Asp Pro Glu 
            20                  25                  30


Val Gln Arg Gln Phe Pro Glu Asp Tyr Ser Asp Gln Glu Val Leu Gln 
        35                  40                  45


Thr Leu Thr Lys Phe Cys Phe Pro Phe Tyr Val Asp Ser Leu Thr Val 
    50                  55                  60


Ser Gln Val Gly Gln Asn Phe Thr Phe Val Leu Thr Asp Ile Asp Ser 
65                  70                  75                  80


Lys Gln Arg Phe Gly Phe Cys Arg Leu Ser Ser Gly Ala Lys Ser Cys 
                85                  90                  95


Phe Cys Ile Leu Ser Tyr Leu Pro Trp Phe Glu Val Phe Tyr Lys Leu 
            100                 105                 110


Leu Asn Ile Leu Ala Asp Tyr Thr Thr Lys Arg Gln Glu Asn Gln Trp 
        115                 120                 125


Asn Glu Leu Leu Glu Thr Leu His Lys Leu Pro Ile Pro Asp Pro Gly 
    130                 135                 140


Val Ser Val His Leu Ser Val His Ser Tyr Phe Thr Val Pro Asp Thr 
145                 150                 155                 160


Arg Glu Leu Pro Ser Ile Pro Glu Asn Arg Asn Leu Thr Glu Tyr Phe 
                165                 170                 175


Val Ala Val Asp Val Asn Asn Met Leu His Leu Tyr Ala Ser Met Leu 
            180                 185                 190


Tyr Glu Arg Arg Ile Leu Ile Ile Cys Ser Lys Leu Ser Thr Leu Thr 
        195                 200                 205


Ala Cys Ile His Gly Ser Ala Ala Met Leu Tyr Pro Met Tyr Trp Gln 
    210                 215                 220


His Val Tyr Ile Pro Val Leu Pro Pro His Leu Leu Asp Tyr Cys Cys 
225                 230                 235                 240


Ala Pro Met Pro Tyr Leu Ile Gly Ile His Leu Ser Leu Met Glu Lys 
                245                 250                 255


Val Arg Asn Met Ala Leu Asp Asp Val Val Ile Leu Asn Val Asp Thr 
            260                 265                 270


Asn Thr Leu Glu Thr Pro Phe Asp Asp Leu Gln Ser Leu Pro Asn Asp 
        275                 280                 285


Val Ile Ser Ser Leu Lys Asn Arg Leu Lys Lys Val Ser Thr Thr Thr 
    290                 295                 300


Gly Asp Gly Val Ala Arg Ala Phe Leu Lys Ala Gln Ala Ala Phe Phe 
305                 310                 315                 320


Gly Ser Tyr Arg Asn Ala Leu Lys Ile Glu Pro Glu Glu Pro Ile Thr 
                325                 330                 335


Phe Cys Glu Glu Ala Phe Val Ser His Tyr Arg Ser Gly Ala Met Arg 
            340                 345                 350


Gln Phe Leu Gln Asn Ala Thr Gln Leu Gln Leu Phe Lys Gln Phe Ile 
        355                 360                 365


Asp Gly Arg Leu Asp Leu Leu Asn Ser Gly Glu Gly Phe Ser Asp Val 
    370                 375                 380


Phe Glu Glu Glu Ile Asn Met Gly Glu Tyr Ala Gly Ser Asp Lys Leu 
385                 390                 395                 400


Tyr His Gln Trp Leu Ser Thr Val Arg Lys Gly Ser Gly Ala Ile Leu 
                405                 410                 415


Asn Thr Val Lys Thr Lys Ala Asn Pro Ala Met Lys Thr Val Tyr Lys 
            420                 425                 430


Phe Ala Lys Asp His Ala Lys Met Gly Ile Lys Glu Val Lys Asn Arg 
        435                 440                 445


Leu Lys Gln Lys Asp Ile Ala Glu Asn Gly Cys Ala Pro Thr Pro Glu 
    450                 455                 460


Glu Gln Leu Pro Lys Thr Ala Pro Ser Pro Leu Val Glu Ala Lys Asp 
465                 470                 475                 480


Pro Lys Leu Arg Glu Asp Arg Arg Pro Ile Thr Val His Phe Gly Gln 
                485                 490                 495


Val Arg Pro Pro Arg Pro His Val Val Lys Arg Pro Lys Ser Asn Ile 
            500                 505                 510


Ala Val Glu Gly Arg Arg Thr Ser Val Pro Ser Pro Glu Gln Asn Thr 
        515                 520                 525


Ile Ala Thr Pro Ala Thr Leu His Ile Leu Gln Lys Ser Ile Thr His 
    530                 535                 540


Phe Ala Ala Lys Phe Pro Thr Arg Gly Trp Thr Ser Ser Ser His 
545                 550                 555


<210>  653
<211>  3273
<212>  DNA
<213>  Homo sapiens

<400>  653
agtccccgcg cagtccccgc gcagtcccag cgccaccggg cagcagcggc gccgtgctcg     60

ctccagggcg caaccatgtc gccatttctt cggattggct tgtccaactt tgactgcggg    120

tcctgccagt cttgtcaggg cgaggctgtt aacccttact gtgctgtgct cgtcaaagag    180

tatgtcgaat cagagaacgg gcagatgtat atccagaaaa agcctaccat gtacccaccc    240

tgggacagca cttttgatgc ccatatcaac aagggaagag tcatgcagat cattgtgaaa    300

ggcaaaaacg tggacctcat ctctgaaacc accgtggagc tctactcgct ggctgagagg    360

tgcaggaaga acaacgggaa gacagaaata tggttagagc tgaaacctca aggccgaatg    420

ctaatgaatg caagatactt tctggaaatg agtgacacaa aggacatgaa tgaatttgag    480

acggaaggct tctttgcttt gcatcagcgc cggggtgcca tcaagcaggc aaaggtccac    540

cacgtcaagt gccacgagtt cactgccacc ttcttcccac agcccacatt ttgctctgtc    600

tgccacgagt ttgtctgggg cctgaacaaa cagggctacc agtgccgaca atgcaatgca    660

gcaattcaca agaagtgtat tgataaagtt atagcaaagt gcacaggatc agctatcaat    720

agccgagaaa ccatgttcca caaggagaga ttcaaaattg acatgccaca cagatttaaa    780

gtctacaatt acaagagccc gaccttctgt gaacactgtg ggaccctgct gtggggactg    840

gcacggcaag gactcaagtg tgatgcatgt ggcatgaatg tgcatcatag atgccagaca    900

aaggtggcca acctttgtgg cataaaccag aagctaatgg ctgaagcgct ggccatgatt    960

gagagcactc aacaggctcg ctgcttaaga gatactgaac agatcttcag agaaggtccg   1020

gttgaaattg gtctcccatg ctccatcaaa aatgaagcaa ggccgccatg tttaccgaca   1080

ccgggaaaaa gagagcctca gggcatttcc tgggagtctc cgttggatga ggtggataaa   1140

atgtgccatc ttccagaacc tgaactgaac aaagaaagac catctctgca gattaaacta   1200

aaaattgagg attttatctt gcacaaaatg ttggggaaag gaagttttgg caaggtcttc   1260

ctggcagaat tcaagaaaac caatcaattt ttcgcaataa aggccttaaa gaaagatgtg   1320

gtcttgatgg acgatgatgt tgagtgcacg atggtagaga agagagttct ttccttggcc   1380

tgggagcatc cgtttctgac gcacatgttt tgtacattcc agaccaagga aaacctcttt   1440

tttgtgatgg agtacctcaa cggaggggac ttaatgtacc acatccaaag ctgccacaag   1500

ttcgaccttt ccagagcgac gttttatgct gctgaaatca ttcttggtct gcagttcctt   1560

cattccaaag gaatagtcta cagggacctg aagctagata acatcctgtt agacaaagat   1620

ggacatatca agatcgcgga ttttggaatg tgcaaggaga acatgttagg agatgccaag   1680

acgaatacct tctgtgggac acctgactac atcgccccag agatcttgct gggtcagaaa   1740

tacaaccact ctgtggactg gtggtccttc ggggttctcc tttatgaaat gctgattggt   1800

cagtcgcctt tccacgggca ggatgaggag gagctcttcc actccatccg catggacaat   1860

cccttttacc cacggtggct ggagaaggaa gcaaaggacc ttctggtgaa gctcttcgtg   1920

cgagaacctg agaagaggct gggcgtgagg ggagacatcc gccagcaccc tttgtttcgg   1980

gagatcaact gggaggaact tgaacggaag gagattgacc caccgttccg gccgaaagtg   2040

aaatcaccat ttgactgcag caatttcgac aaagaattct taaacgagaa gccccggctg   2100

tcatttgccg acagagcact gatcaacagc atggaccaga atatgttcag gaacttttcc   2160

ttcatgaacc ccgggatgga gcggctgata tcctgaatct tgcccctcca gagacaggaa   2220

agaatttgcc ttctccctgg gaactggttc aagagacact gcttgggttc ctttttcaac   2280

ttggaaaaag aaagaaacac tcaacaataa agactgagac ccgttcgccc ccatgtgact   2340

tttatctgta gcagaaacca agtctacttc actaatgacg atgccgtgtg tctcgtctcc   2400

tgacatgtct cacagacgct cctgaagtta ggtcattact aaccatagtt atttacttga   2460

aagatgggtc tccgcacttg gaaaggtttc aagacttgat actgcaataa attatggctc   2520

ttcacctggg cgccaactgc tgatcaatga aatgcttgtt gaatcagggg caaacggagt   2580

acagacgtct caagactgaa acggccccat tgcctggtct agtagcggat ctcactcagc   2640

cgcagacaag taatcactaa cccgttttat tctattccta tctgtggatg tgtaaatggc   2700

tggggggcca gccctggata ggtttttatg ggaattcttt acaataaaca tagcttgtaa   2760

cttgagatct acaaatccat tcatcctgat tgggcatgaa atccatggtc aagaggacaa   2820

gtggaaagtg agagggaagg tttgctagac accttcgctt gttatcttgt caagatagaa   2880

aagatagtat catttcaccc ttgccagtaa aaacctttcc atccacccat tctcagcaga   2940

ctccagtatt ggcacagtca ctcactgcca ttctcacact ataacaagaa aagaaatgaa   3000

gtgcataagt ctcctgggaa aagaacctta accccttctc gtgccatgac tggtgatttc   3060

atgactcata agcccctccg taggcatcat tcaagatcaa tggcccatgc atgctgtttg   3120

cagcagtcaa ttgagttgaa ttagaattcc aaccatacat tttaaaggta tttgtgctgt   3180

gtgtatattt tgataaaatg ttgtgacttc atggcaaaca ggtggatgtg taaaaatgga   3240

ataaaaaaaa aaaaagagtc aaaaaaaaaa aaa                                3273


<210>  654
<211>  706
<212>  PRT
<213>  Homo sapiens

<400>  654

Met Ser Pro Phe Leu Arg Ile Gly Leu Ser Asn Phe Asp Cys Gly Ser 
1               5                   10                  15


Cys Gln Ser Cys Gln Gly Glu Ala Val Asn Pro Tyr Cys Ala Val Leu 
            20                  25                  30


Val Lys Glu Tyr Val Glu Ser Glu Asn Gly Gln Met Tyr Ile Gln Lys 
        35                  40                  45


Lys Pro Thr Met Tyr Pro Pro Trp Asp Ser Thr Phe Asp Ala His Ile 
    50                  55                  60


Asn Lys Gly Arg Val Met Gln Ile Ile Val Lys Gly Lys Asn Val Asp 
65                  70                  75                  80


Leu Ile Ser Glu Thr Thr Val Glu Leu Tyr Ser Leu Ala Glu Arg Cys 
                85                  90                  95


Arg Lys Asn Asn Gly Lys Thr Glu Ile Trp Leu Glu Leu Lys Pro Gln 
            100                 105                 110


Gly Arg Met Leu Met Asn Ala Arg Tyr Phe Leu Glu Met Ser Asp Thr 
        115                 120                 125


Lys Asp Met Asn Glu Phe Glu Thr Glu Gly Phe Phe Ala Leu His Gln 
    130                 135                 140


Arg Arg Gly Ala Ile Lys Gln Ala Lys Val His His Val Lys Cys His 
145                 150                 155                 160


Glu Phe Thr Ala Thr Phe Phe Pro Gln Pro Thr Phe Cys Ser Val Cys 
                165                 170                 175


His Glu Phe Val Trp Gly Leu Asn Lys Gln Gly Tyr Gln Cys Arg Gln 
            180                 185                 190


Cys Asn Ala Ala Ile His Lys Lys Cys Ile Asp Lys Val Ile Ala Lys 
        195                 200                 205


Cys Thr Gly Ser Ala Ile Asn Ser Arg Glu Thr Met Phe His Lys Glu 
    210                 215                 220


Arg Phe Lys Ile Asp Met Pro His Arg Phe Lys Val Tyr Asn Tyr Lys 
225                 230                 235                 240


Ser Pro Thr Phe Cys Glu His Cys Gly Thr Leu Leu Trp Gly Leu Ala 
                245                 250                 255


Arg Gln Gly Leu Lys Cys Asp Ala Cys Gly Met Asn Val His His Arg 
            260                 265                 270


Cys Gln Thr Lys Val Ala Asn Leu Cys Gly Ile Asn Gln Lys Leu Met 
        275                 280                 285


Ala Glu Ala Leu Ala Met Ile Glu Ser Thr Gln Gln Ala Arg Cys Leu 
    290                 295                 300


Arg Asp Thr Glu Gln Ile Phe Arg Glu Gly Pro Val Glu Ile Gly Leu 
305                 310                 315                 320


Pro Cys Ser Ile Lys Asn Glu Ala Arg Pro Pro Cys Leu Pro Thr Pro 
                325                 330                 335


Gly Lys Arg Glu Pro Gln Gly Ile Ser Trp Glu Ser Pro Leu Asp Glu 
            340                 345                 350


Val Asp Lys Met Cys His Leu Pro Glu Pro Glu Leu Asn Lys Glu Arg 
        355                 360                 365


Pro Ser Leu Gln Ile Lys Leu Lys Ile Glu Asp Phe Ile Leu His Lys 
    370                 375                 380


Met Leu Gly Lys Gly Ser Phe Gly Lys Val Phe Leu Ala Glu Phe Lys 
385                 390                 395                 400


Lys Thr Asn Gln Phe Phe Ala Ile Lys Ala Leu Lys Lys Asp Val Val 
                405                 410                 415


Leu Met Asp Asp Asp Val Glu Cys Thr Met Val Glu Lys Arg Val Leu 
            420                 425                 430


Ser Leu Ala Trp Glu His Pro Phe Leu Thr His Met Phe Cys Thr Phe 
        435                 440                 445


Gln Thr Lys Glu Asn Leu Phe Phe Val Met Glu Tyr Leu Asn Gly Gly 
    450                 455                 460


Asp Leu Met Tyr His Ile Gln Ser Cys His Lys Phe Asp Leu Ser Arg 
465                 470                 475                 480


Ala Thr Phe Tyr Ala Ala Glu Ile Ile Leu Gly Leu Gln Phe Leu His 
                485                 490                 495


Ser Lys Gly Ile Val Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu 
            500                 505                 510


Asp Lys Asp Gly His Ile Lys Ile Ala Asp Phe Gly Met Cys Lys Glu 
        515                 520                 525


Asn Met Leu Gly Asp Ala Lys Thr Asn Thr Phe Cys Gly Thr Pro Asp 
    530                 535                 540


Tyr Ile Ala Pro Glu Ile Leu Leu Gly Gln Lys Tyr Asn His Ser Val 
545                 550                 555                 560


Asp Trp Trp Ser Phe Gly Val Leu Leu Tyr Glu Met Leu Ile Gly Gln 
                565                 570                 575


Ser Pro Phe His Gly Gln Asp Glu Glu Glu Leu Phe His Ser Ile Arg 
            580                 585                 590


Met Asp Asn Pro Phe Tyr Pro Arg Trp Leu Glu Lys Glu Ala Lys Asp 
        595                 600                 605


Leu Leu Val Lys Leu Phe Val Arg Glu Pro Glu Lys Arg Leu Gly Val 
    610                 615                 620


Arg Gly Asp Ile Arg Gln His Pro Leu Phe Arg Glu Ile Asn Trp Glu 
625                 630                 635                 640


Glu Leu Glu Arg Lys Glu Ile Asp Pro Pro Phe Arg Pro Lys Val Lys 
                645                 650                 655


Ser Pro Phe Asp Cys Ser Asn Phe Asp Lys Glu Phe Leu Asn Glu Lys 
            660                 665                 670


Pro Arg Leu Ser Phe Ala Asp Arg Ala Leu Ile Asn Ser Met Asp Gln 
        675                 680                 685


Asn Met Phe Arg Asn Phe Ser Phe Met Asn Pro Gly Met Glu Arg Leu 
    690                 695                 700


Ile Ser 
705


<210>  655
<211>  7773
<212>  DNA
<213>  Homo sapiens

<400>  655
agagcctcgg tggtttgcag cagtggaacc aggcaggccc agttgtgggt aggagaggcc     60

gtcacctgtt gaggcctccc ccccacaccc ccgcatcgcc ctgccctggc agagcccagc    120

ccccagtccc cggagagcgc gcctgaggac ggacggacgg acggacggac agacctaggg    180

acggagggcc aggggcaggg gagatccaag aggccccgcg ctggaatgca gttttctcgg    240

gcgagggaga ctttgcaccg gagtggaaaa tagtttgggg tggggtttcg caccgtcccc    300

tcctccccag ccccgggccc cctcccaggc gctttctggg agcttttaga actgcgctct    360

gaagtttcca gagagcgagg agcttttgcg gcaggcagag acaatggaag aaaatgaaag    420

ccagaaatgt gagccgtgcc ttccttactc agcagacaga agacagatgc aggaacaagg    480

caaaggcaat ctgcatgtaa catcaccaga agatgcagaa tgccgcagaa ccaaggaacg    540

cctttctaat ggaaacagtc gtggttcagt ttccaagtct tcccgcaata tcccaaggag    600

acacacccta ggggggcccc gaagttccaa ggaaatactg ggaatgcaaa catctgagat    660

ggatcggaag agagaagcgt tcctagaaca tctgaagcag aagtaccccc accacgcctc    720

tgcaatcatg ggtcaccaag agaggctgag agaccagaca aggagcccca aactgtctca    780

cagtcctcaa ccacccagtc tgggtgaccc ggtcgagcat ttatcagaga cgtccgctga    840

ttctttggaa gccatgtctg agggggatgc tccaacccct ttttccagag gcagccggac    900

tcgtgcgagc cttcctgtgg tgaggtcaac caaccagacg aaagaaagat ctctgggggt    960

tctctatctc cagtatggag atgaaaccaa gcagctcagg atgccgaatg aaatcacaag   1020

tgcagacaca atccgtgctc tcttcgtaag tgcctttcca cagcagctca ccatgaaaat   1080

gctggaatcg cccagtgtcg ccatttacat caaagatgaa agcagaaatg tctattatga   1140

attaaatgat gtaaggaaca ttcaagacag atcactcctc aaagtgtaca acaaggatcc   1200

tgcacatgcg tttaatcaca caccaaaaac tatgaatgga gacatgagga tgcagagaga   1260

acttgtttat gcaagaggag atggccctgg ggcccctcgc cccggatcta ctgctcatcc   1320

accccatgcg attccaaatt ccccaccgtc tactccagtg ccccattcca tgcccccctc   1380

cccgtccaga attccttatg ggggcacccg ctccatggtt gttcctggca atgccaccat   1440

ccccagggac agaatctcca gcctgccagt ctccagaccc atctctccaa gcccaagcgc   1500

cattttagaa agaagagatg tcaagcctga tgaagacatg agtggcaaaa acattgcaat   1560

gtacagaaat gagggtttct atgctgatcc ttacctttat cacgagggac ggatgagcat   1620

agcctcatcc catggtggac acccactgga tgtccccgac cacatcattg catatcaccg   1680

caccgccatc cggtcagcga gtgcttattg taacccctca atgcaagcgg aaatgcatat   1740

ggaacaatca ctgtacagac agaaatcaag gaaatatccg gatagccatt tgcctacact   1800

gggctccaaa acaccccctg cctctcctca cagagtcagt gacctgagga tgatagacat   1860

gcacgctcac tataatgccc acggcccccc tcacaccatg cagccagacc gggcctctcc   1920

gagccgccag gcctttaaaa aggagccagg caccttggtg tatatagaaa agccacggag   1980

cgctgcagga ttatccagcc ttgtagacct cggccctcct ctaatggaga agcaagtttt   2040

tgcctacagc acggcgacaa tacccaaaga cagagagacc agagagagga tgcaagccat   2100

ggagaaacag attgccagtt taactggcct tgttcagtct gcgcttttta aagggcccat   2160

tacaagttat agcaaagatg cgtctagcga gaaaatgatg aaaaccacag ccaacaggaa   2220

ccacacagat agtgcaggaa cgccccatgt gtctggtggg aagatgctca gtgctctgga   2280

gtccacggtg cctcccagcc agcctccacc tgtgggcacc tcagccatcc acatgagcct   2340

gcttgagatg aggcggagcg tggcggaact caggctccag ctccagcaga tgcggcagct   2400

ccagctgcag aaccaggagt tgctgagggc aatgatgaag aaggccgagc tggaaatcag   2460

tggcaaagtg atggaaacaa tgaagagact ggaggatccc gtgcagcgac agcgcgtcct   2520

agtggagcaa gagagacaaa aatatcttca tgaggaagag aagatcgtca agaagttgtg   2580

cgagttggaa gactttgttg aagacttgaa gaaggactcc acggcagcca gccgattggt   2640

tactctgaaa gacgtggaag acggggcttt cctcctgcgt caagtgggag aggctgtagc   2700

taccctgaaa ggagaatttc caaccttaca aaacaagatg cgagccatcc tgcgcataga   2760

agtggaggcc gtgcggtttc tgaaggagga gccacacaag ctggacagtc tcctgaagcg   2820

tgtgcgcagc atgacagacg tcctgaccat gctgcggaga catgtcactg atgggctcct   2880

gaaaggcacg gacgcagccc aagccgcaca gtacatggct atggaaaagg ccacagccgc   2940

agaagtcctg aagagtcagg aggaggcagc ccacacctcc ggccagccct tccacagcac   3000

aggtgcccct ggcgatgcga agtcggaagt ggtgcctttg tccggcatga tggttcgcca   3060

cgcgcagagc tcccctgtgg tcatccagcc ctcccagcac tccgtggccc tgctgaaccc   3120

tgctcagaac ttgcctcacg tggccagctc cccagccgtc ccccaggaag caacctccac   3180

tctgcagatg tcgcaggctc cgcagtcccc acagataccc atgaatgggt ctgccatgca   3240

gagcttgttc attgaagaaa tccacagtgt gagtgccaag aacagggcag tgtctatcga   3300

gaaagcagaa aagaaatggg aggaaaaaag gcaaaatctg gatcactata atgggaaaga   3360

gtttgagaag ctcctagaag aagctcaggc caatatcatg aagtcaatac caaatctgga   3420

gatgccgcca gccacaggcc cactgccaag gggagatgcc ccagtggaca aggtggaact   3480

ttcagaagat tctccaaatt cggaacagga cttggaaaag ctggggggaa agtcgccccc   3540

tcctcctccg ccacctcctc gtcgaagcta cctgccagga tcgggactca ccaccacgag   3600

gtcaggcgat gtggtctaca ccggcagaaa ggagaacatc accgctaagg caagcagtga   3660

agatgctgga ccaagcccac agaccagagc tacaaaatat ccagcagagg agcctgcttc   3720

agcctggacc ccatccccac cgcctgtcac cacctcctcc tcaaaggatg aggaggaaga   3780

agaagaagaa ggagacaaaa taatggcaga actccaggca ttccagaagt gttcctttat   3840

ggatgtaaat tcaaacagtc atgctgagcc atcccgggct gacagtcacg ttaaagacac   3900

taggtcgggc gccacagtgc cacccaagga gaagaagaat ttggaatttt tccatgaaga   3960

tgtacggaaa tctgatgttg aatatgaaaa tggcccccaa atggaattcc aaaaggttac   4020

cacaggggct gtaagaccta gtgaccctcc taagtgggaa agaggaatgg agaatagtat   4080

ttctgatgca tcaagaacat cagaatataa aactgagatc ataatgaagg aaaattccat   4140

atccaatatg agtttactca gagacagtag aaactattcc caggaaactg tgcctaaggc   4200

cagtttcggt ttctctggca ttagtccatt agaagatgaa ataaacaaag ggtctaaaat   4260

ctcaggcctg caatactcta tacctgacac cgagaaccag acgctgaatt acggaaagac   4320

aaaggagatg gaaaagcaaa atacggataa gtgtcacgtt tcctctcaca ctagactaac   4380

agaatcaagc gtgcatgatt ttaaaacaga agatcaagag gttatcacga cagattttgg   4440

ccaagttgtt ctaagaccca aggaggcaag gcatgctaac gtgaacccta atgaggatgg   4500

agaatcaagt tcaagttctc ccactgaaga aaatgcagcc actgacaata ttgccttcat   4560

gattaccgaa accactgtcc aggttctttc cagtggggag gtgcatgata ttgttagcca   4620

aaagggagaa gacatacaga cggttaatat cgatgccaga aaagagatga ccccccgaca   4680

agaagggact gacaatgagg atccagtcgt gtgcctggac aagaaaccag tgatcatcat   4740

tttcgatgag cccatggaca tccggtctgc ctataagaga ctttcaacta tctttgagga   4800

atgtgatgag gaattagaga gaatgatgat ggaggaaaag atagaggagg aggaagagga   4860

ggaaaatggg gattctgtag tccagaataa taacacttcc cagatgtctc ataagaaggt   4920

ggccccaggc aatcttagaa ccggacaaca ggtggaaaca aagtcacagc cacactccct   4980

ggccacagag accagaaacc caggaggaca ggaaatgaac agaacggagc tgaacaagtt   5040

cagccacgtg gattctccaa attcggaatg caagggtgag gacgcgaccg atgaccagtt   5100

tgaaagcccc aagaaaaagt ttaaattcaa attccctaag aagcaactcg ccgctctcac   5160

tcaagccatt cgcaccggaa ctaaaacagg gaagaagact ttgcaagtgg tagtctatga   5220

agaagaggaa gaggatggca ccctgaaaca gcacaaagaa gccaagcgct tcgaaatcgc   5280

taggtctcaa cctgaagaca cccctgaaaa cacagtgagg aggcaagagc agcccagcat   5340

cgagagtaca tctccgattt caagaactga tgaaattaga aaaaacacct acagaacatt   5400

ggatagcctg gagcagacca ttaaacagct cgaaaataca atcagtgaaa tgagtcccaa   5460

agccctagtt gatacctcat gttcttccaa cagagattct gttgcaagtt catcccacat   5520

agcccaagag gcctctcccc gacccttgct agttccggat gaaggtccca ctgccctaga   5580

gccccctacg tcgatacctt cagcttcacg taagggctcc agcggggccc cacagacgag   5640

caggatgcct gtccccatga gtgccaagaa cagacccgga accctggaca aacccggcaa   5700

gcagtccaaa ctgcaggatc cccgccaata tcgtcaggct aatggaagtg ctaagaaatc   5760

tggtggggac tttaagccta cttccccctc cttacctgct tctaagattc cagccctttc   5820

tcccagctct gggaaaagca gttctctgcc ctcttctagt ggtgacagct ctaacctccc   5880

taatccacct gctactaaac catcgattgc ttctaaccct ctcagccccc aaacaggacc   5940

acctgctcac tctgcctccc tcatcccttc tgtctctaat ggctctttga agtttcagag   6000

cctcactcat acaggtaaag gtcaccatct ttcattctca ccgcagagtc aaaatggccg   6060

agcaccccct cctttgtcat tttcctcctc ccctccttct cctgcctcct ccgtctcact   6120

gaatcaaggt gccaagggca ccaggaccat ccatactccc agcctcacca gctacaaggc   6180

acagaatgga agttcaagca aagccacccc atccacagca aaagaaacct cttaaaggtc   6240

aaatcctatt aggcacaagt cggagttaca tttaaaaaaa attaacagtc tacaacaact   6300

gttttcacaa gagaatgtaa catattgctg tatcgtttga ggcttaatgc taaatatgtg   6360

ctaaatactg gattaataga tttcagtaaa gctcgttcgt tttgtttggt tttcttttta   6420

cctagttgct atagtgtcta cagtctatac tcaataccta taaaatgcag taagcatgtg   6480

ttacagaaag aggttctggt gggagagaaa ggtgcgtgtg agacaggaga attgtcttaa   6540

gcatataaaa catgtatgat tccagaattt tagtatgttt tgtataaaac tatttttcat   6600

tacggagact agaagtgaac agagaattac acaagtgtga ctatacaaat tgtaaaacag   6660

atactataat atttcctttt attttagtgt tatttagctt tattacagat ttctattttt   6720

gtcaaaactt catggttcct ttcaagatct tttttgccaa aacattttga tactatagca   6780

ttgtacattt gaaagtagtg ttctagacta taaaaccaat gaacttctac atgagcccta   6840

cagacaggca tgtgtagaag gcaatttatc aaacctattg cactgccatg aaaagtgtgt   6900

ataataattt gctagcccaa gcaagctagt tttctttgct tgcttctttt ctttcttttt   6960

tccttccttt tttttttttt tttctttttt aacatgttga gattctctag ttgttttctt   7020

tggcgtatct aaccccttct tttgttttct gagacctggt aacccacgct cttgcattgt   7080

ggattttaaa atgtatactc tgtacggttc tgtaaaccga aaaacttttg taaatatata   7140

aatatacata gacataaaaa tactgtatgt gacagcacat agagtagttt tcccacacca   7200

aagttaattt ttatgcatgc tttaaaagta tatatcggga ccggcagaaa tggaagtatc   7260

catacatttt taaaaagcaa caagtttgca cagctagagt gtttttgtaa ataaatgtat   7320

ttgtataaca cagtcatgta atatacagaa ctataagcag agactttgca aaactaaata   7380

aagggctgca tgcttattat tttttgtacc ttgtcactat aactacttcc tagtcaaaga   7440

acgaaatgta actgttaccg agttaaatgt ttttccgctt tgagggatgt aaccacatcc   7500

actcagagga cactactttt ctgaaagctc tggggtgact aatgatgagt tcctaataaa   7560

ttaattgcaa gtgtggtgcc ttggatgtgg cctgttggct cgctttcttc tctgtggctt   7620

atcaaggtgt agatgacaga aagcaaacct ggatacagag tttccaccct cagttcctgg   7680

aggggctctt attattttct ctctttttaa aaaacttcca gtagaagtaa agtggaaata   7740

aaatgtcttt atcaaaaaaa aaaaaaaaaa aaa                                7773


<210>  656
<211>  1943
<212>  PRT
<213>  Homo sapiens

<400>  656

Met Glu Glu Asn Glu Ser Gln Lys Cys Glu Pro Cys Leu Pro Tyr Ser 
1               5                   10                  15


Ala Asp Arg Arg Gln Met Gln Glu Gln Gly Lys Gly Asn Leu His Val 
            20                  25                  30


Thr Ser Pro Glu Asp Ala Glu Cys Arg Arg Thr Lys Glu Arg Leu Ser 
        35                  40                  45


Asn Gly Asn Ser Arg Gly Ser Val Ser Lys Ser Ser Arg Asn Ile Pro 
    50                  55                  60


Arg Arg His Thr Leu Gly Gly Pro Arg Ser Ser Lys Glu Ile Leu Gly 
65                  70                  75                  80


Met Gln Thr Ser Glu Met Asp Arg Lys Arg Glu Ala Phe Leu Glu His 
                85                  90                  95


Leu Lys Gln Lys Tyr Pro His His Ala Ser Ala Ile Met Gly His Gln 
            100                 105                 110


Glu Arg Leu Arg Asp Gln Thr Arg Ser Pro Lys Leu Ser His Ser Pro 
        115                 120                 125


Gln Pro Pro Ser Leu Gly Asp Pro Val Glu His Leu Ser Glu Thr Ser 
    130                 135                 140


Ala Asp Ser Leu Glu Ala Met Ser Glu Gly Asp Ala Pro Thr Pro Phe 
145                 150                 155                 160


Ser Arg Gly Ser Arg Thr Arg Ala Ser Leu Pro Val Val Arg Ser Thr 
                165                 170                 175


Asn Gln Thr Lys Glu Arg Ser Leu Gly Val Leu Tyr Leu Gln Tyr Gly 
            180                 185                 190


Asp Glu Thr Lys Gln Leu Arg Met Pro Asn Glu Ile Thr Ser Ala Asp 
        195                 200                 205


Thr Ile Arg Ala Leu Phe Val Ser Ala Phe Pro Gln Gln Leu Thr Met 
    210                 215                 220


Lys Met Leu Glu Ser Pro Ser Val Ala Ile Tyr Ile Lys Asp Glu Ser 
225                 230                 235                 240


Arg Asn Val Tyr Tyr Glu Leu Asn Asp Val Arg Asn Ile Gln Asp Arg 
                245                 250                 255


Ser Leu Leu Lys Val Tyr Asn Lys Asp Pro Ala His Ala Phe Asn His 
            260                 265                 270


Thr Pro Lys Thr Met Asn Gly Asp Met Arg Met Gln Arg Glu Leu Val 
        275                 280                 285


Tyr Ala Arg Gly Asp Gly Pro Gly Ala Pro Arg Pro Gly Ser Thr Ala 
    290                 295                 300


His Pro Pro His Ala Ile Pro Asn Ser Pro Pro Ser Thr Pro Val Pro 
305                 310                 315                 320


His Ser Met Pro Pro Ser Pro Ser Arg Ile Pro Tyr Gly Gly Thr Arg 
                325                 330                 335


Ser Met Val Val Pro Gly Asn Ala Thr Ile Pro Arg Asp Arg Ile Ser 
            340                 345                 350


Ser Leu Pro Val Ser Arg Pro Ile Ser Pro Ser Pro Ser Ala Ile Leu 
        355                 360                 365


Glu Arg Arg Asp Val Lys Pro Asp Glu Asp Met Ser Gly Lys Asn Ile 
    370                 375                 380


Ala Met Tyr Arg Asn Glu Gly Phe Tyr Ala Asp Pro Tyr Leu Tyr His 
385                 390                 395                 400


Glu Gly Arg Met Ser Ile Ala Ser Ser His Gly Gly His Pro Leu Asp 
                405                 410                 415


Val Pro Asp His Ile Ile Ala Tyr His Arg Thr Ala Ile Arg Ser Ala 
            420                 425                 430


Ser Ala Tyr Cys Asn Pro Ser Met Gln Ala Glu Met His Met Glu Gln 
        435                 440                 445


Ser Leu Tyr Arg Gln Lys Ser Arg Lys Tyr Pro Asp Ser His Leu Pro 
    450                 455                 460


Thr Leu Gly Ser Lys Thr Pro Pro Ala Ser Pro His Arg Val Ser Asp 
465                 470                 475                 480


Leu Arg Met Ile Asp Met His Ala His Tyr Asn Ala His Gly Pro Pro 
                485                 490                 495


His Thr Met Gln Pro Asp Arg Ala Ser Pro Ser Arg Gln Ala Phe Lys 
            500                 505                 510


Lys Glu Pro Gly Thr Leu Val Tyr Ile Glu Lys Pro Arg Ser Ala Ala 
        515                 520                 525


Gly Leu Ser Ser Leu Val Asp Leu Gly Pro Pro Leu Met Glu Lys Gln 
    530                 535                 540


Val Phe Ala Tyr Ser Thr Ala Thr Ile Pro Lys Asp Arg Glu Thr Arg 
545                 550                 555                 560


Glu Arg Met Gln Ala Met Glu Lys Gln Ile Ala Ser Leu Thr Gly Leu 
                565                 570                 575


Val Gln Ser Ala Leu Phe Lys Gly Pro Ile Thr Ser Tyr Ser Lys Asp 
            580                 585                 590


Ala Ser Ser Glu Lys Met Met Lys Thr Thr Ala Asn Arg Asn His Thr 
        595                 600                 605


Asp Ser Ala Gly Thr Pro His Val Ser Gly Gly Lys Met Leu Ser Ala 
    610                 615                 620


Leu Glu Ser Thr Val Pro Pro Ser Gln Pro Pro Pro Val Gly Thr Ser 
625                 630                 635                 640


Ala Ile His Met Ser Leu Leu Glu Met Arg Arg Ser Val Ala Glu Leu 
                645                 650                 655


Arg Leu Gln Leu Gln Gln Met Arg Gln Leu Gln Leu Gln Asn Gln Glu 
            660                 665                 670


Leu Leu Arg Ala Met Met Lys Lys Ala Glu Leu Glu Ile Ser Gly Lys 
        675                 680                 685


Val Met Glu Thr Met Lys Arg Leu Glu Asp Pro Val Gln Arg Gln Arg 
    690                 695                 700


Val Leu Val Glu Gln Glu Arg Gln Lys Tyr Leu His Glu Glu Glu Lys 
705                 710                 715                 720


Ile Val Lys Lys Leu Cys Glu Leu Glu Asp Phe Val Glu Asp Leu Lys 
                725                 730                 735


Lys Asp Ser Thr Ala Ala Ser Arg Leu Val Thr Leu Lys Asp Val Glu 
            740                 745                 750


Asp Gly Ala Phe Leu Leu Arg Gln Val Gly Glu Ala Val Ala Thr Leu 
        755                 760                 765


Lys Gly Glu Phe Pro Thr Leu Gln Asn Lys Met Arg Ala Ile Leu Arg 
    770                 775                 780


Ile Glu Val Glu Ala Val Arg Phe Leu Lys Glu Glu Pro His Lys Leu 
785                 790                 795                 800


Asp Ser Leu Leu Lys Arg Val Arg Ser Met Thr Asp Val Leu Thr Met 
                805                 810                 815


Leu Arg Arg His Val Thr Asp Gly Leu Leu Lys Gly Thr Asp Ala Ala 
            820                 825                 830


Gln Ala Ala Gln Tyr Met Ala Met Glu Lys Ala Thr Ala Ala Glu Val 
        835                 840                 845


Leu Lys Ser Gln Glu Glu Ala Ala His Thr Ser Gly Gln Pro Phe His 
    850                 855                 860


Ser Thr Gly Ala Pro Gly Asp Ala Lys Ser Glu Val Val Pro Leu Ser 
865                 870                 875                 880


Gly Met Met Val Arg His Ala Gln Ser Ser Pro Val Val Ile Gln Pro 
                885                 890                 895


Ser Gln His Ser Val Ala Leu Leu Asn Pro Ala Gln Asn Leu Pro His 
            900                 905                 910


Val Ala Ser Ser Pro Ala Val Pro Gln Glu Ala Thr Ser Thr Leu Gln 
        915                 920                 925


Met Ser Gln Ala Pro Gln Ser Pro Gln Ile Pro Met Asn Gly Ser Ala 
    930                 935                 940


Met Gln Ser Leu Phe Ile Glu Glu Ile His Ser Val Ser Ala Lys Asn 
945                 950                 955                 960


Arg Ala Val Ser Ile Glu Lys Ala Glu Lys Lys Trp Glu Glu Lys Arg 
                965                 970                 975


Gln Asn Leu Asp His Tyr Asn Gly Lys Glu Phe Glu Lys Leu Leu Glu 
            980                 985                 990


Glu Ala Gln Ala Asn Ile Met Lys Ser Ile Pro Asn Leu Glu Met Pro 
        995                 1000                1005


Pro Ala Thr Gly Pro Leu Pro Arg Gly Asp Ala Pro Val Asp Lys Val 
    1010                1015                1020


Glu Leu Ser Glu Asp Ser Pro Asn Ser Glu Gln Asp Leu Glu Lys Leu 
1025                1030                1035                1040


Gly Gly Lys Ser Pro Pro Pro Pro Pro Pro Pro Pro Arg Arg Ser Tyr 
                1045                1050                1055


Leu Pro Gly Ser Gly Leu Thr Thr Thr Arg Ser Gly Asp Val Val Tyr 
            1060                1065                1070


Thr Gly Arg Lys Glu Asn Ile Thr Ala Lys Ala Ser Ser Glu Asp Ala 
        1075                1080                1085


Gly Pro Ser Pro Gln Thr Arg Ala Thr Lys Tyr Pro Ala Glu Glu Pro 
    1090                1095                1100


Ala Ser Ala Trp Thr Pro Ser Pro Pro Pro Val Thr Thr Ser Ser Ser 
1105                1110                1115                1120


Lys Asp Glu Glu Glu Glu Glu Glu Glu Gly Asp Lys Ile Met Ala Glu 
                1125                1130                1135


Leu Gln Ala Phe Gln Lys Cys Ser Phe Met Asp Val Asn Ser Asn Ser 
            1140                1145                1150


His Ala Glu Pro Ser Arg Ala Asp Ser His Val Lys Asp Thr Arg Ser 
        1155                1160                1165


Gly Ala Thr Val Pro Pro Lys Glu Lys Lys Asn Leu Glu Phe Phe His 
    1170                1175                1180


Glu Asp Val Arg Lys Ser Asp Val Glu Tyr Glu Asn Gly Pro Gln Met 
1185                1190                1195                1200


Glu Phe Gln Lys Val Thr Thr Gly Ala Val Arg Pro Ser Asp Pro Pro 
                1205                1210                1215


Lys Trp Glu Arg Gly Met Glu Asn Ser Ile Ser Asp Ala Ser Arg Thr 
            1220                1225                1230


Ser Glu Tyr Lys Thr Glu Ile Ile Met Lys Glu Asn Ser Ile Ser Asn 
        1235                1240                1245


Met Ser Leu Leu Arg Asp Ser Arg Asn Tyr Ser Gln Glu Thr Val Pro 
    1250                1255                1260


Lys Ala Ser Phe Gly Phe Ser Gly Ile Ser Pro Leu Glu Asp Glu Ile 
1265                1270                1275                1280


Asn Lys Gly Ser Lys Ile Ser Gly Leu Gln Tyr Ser Ile Pro Asp Thr 
                1285                1290                1295


Glu Asn Gln Thr Leu Asn Tyr Gly Lys Thr Lys Glu Met Glu Lys Gln 
            1300                1305                1310


Asn Thr Asp Lys Cys His Val Ser Ser His Thr Arg Leu Thr Glu Ser 
        1315                1320                1325


Ser Val His Asp Phe Lys Thr Glu Asp Gln Glu Val Ile Thr Thr Asp 
    1330                1335                1340


Phe Gly Gln Val Val Leu Arg Pro Lys Glu Ala Arg His Ala Asn Val 
1345                1350                1355                1360


Asn Pro Asn Glu Asp Gly Glu Ser Ser Ser Ser Ser Pro Thr Glu Glu 
                1365                1370                1375


Asn Ala Ala Thr Asp Asn Ile Ala Phe Met Ile Thr Glu Thr Thr Val 
            1380                1385                1390


Gln Val Leu Ser Ser Gly Glu Val His Asp Ile Val Ser Gln Lys Gly 
        1395                1400                1405


Glu Asp Ile Gln Thr Val Asn Ile Asp Ala Arg Lys Glu Met Thr Pro 
    1410                1415                1420


Arg Gln Glu Gly Thr Asp Asn Glu Asp Pro Val Val Cys Leu Asp Lys 
1425                1430                1435                1440


Lys Pro Val Ile Ile Ile Phe Asp Glu Pro Met Asp Ile Arg Ser Ala 
                1445                1450                1455


Tyr Lys Arg Leu Ser Thr Ile Phe Glu Glu Cys Asp Glu Glu Leu Glu 
            1460                1465                1470


Arg Met Met Met Glu Glu Lys Ile Glu Glu Glu Glu Glu Glu Glu Asn 
        1475                1480                1485


Gly Asp Ser Val Val Gln Asn Asn Asn Thr Ser Gln Met Ser His Lys 
    1490                1495                1500


Lys Val Ala Pro Gly Asn Leu Arg Thr Gly Gln Gln Val Glu Thr Lys 
1505                1510                1515                1520


Ser Gln Pro His Ser Leu Ala Thr Glu Thr Arg Asn Pro Gly Gly Gln 
                1525                1530                1535


Glu Met Asn Arg Thr Glu Leu Asn Lys Phe Ser His Val Asp Ser Pro 
            1540                1545                1550


Asn Ser Glu Cys Lys Gly Glu Asp Ala Thr Asp Asp Gln Phe Glu Ser 
        1555                1560                1565


Pro Lys Lys Lys Phe Lys Phe Lys Phe Pro Lys Lys Gln Leu Ala Ala 
    1570                1575                1580


Leu Thr Gln Ala Ile Arg Thr Gly Thr Lys Thr Gly Lys Lys Thr Leu 
1585                1590                1595                1600


Gln Val Val Val Tyr Glu Glu Glu Glu Glu Asp Gly Thr Leu Lys Gln 
                1605                1610                1615


His Lys Glu Ala Lys Arg Phe Glu Ile Ala Arg Ser Gln Pro Glu Asp 
            1620                1625                1630


Thr Pro Glu Asn Thr Val Arg Arg Gln Glu Gln Pro Ser Ile Glu Ser 
        1635                1640                1645


Thr Ser Pro Ile Ser Arg Thr Asp Glu Ile Arg Lys Asn Thr Tyr Arg 
    1650                1655                1660


Thr Leu Asp Ser Leu Glu Gln Thr Ile Lys Gln Leu Glu Asn Thr Ile 
1665                1670                1675                1680


Ser Glu Met Ser Pro Lys Ala Leu Val Asp Thr Ser Cys Ser Ser Asn 
                1685                1690                1695


Arg Asp Ser Val Ala Ser Ser Ser His Ile Ala Gln Glu Ala Ser Pro 
            1700                1705                1710


Arg Pro Leu Leu Val Pro Asp Glu Gly Pro Thr Ala Leu Glu Pro Pro 
        1715                1720                1725


Thr Ser Ile Pro Ser Ala Ser Arg Lys Gly Ser Ser Gly Ala Pro Gln 
    1730                1735                1740


Thr Ser Arg Met Pro Val Pro Met Ser Ala Lys Asn Arg Pro Gly Thr 
1745                1750                1755                1760


Leu Asp Lys Pro Gly Lys Gln Ser Lys Leu Gln Asp Pro Arg Gln Tyr 
                1765                1770                1775


Arg Gln Ala Asn Gly Ser Ala Lys Lys Ser Gly Gly Asp Phe Lys Pro 
            1780                1785                1790


Thr Ser Pro Ser Leu Pro Ala Ser Lys Ile Pro Ala Leu Ser Pro Ser 
        1795                1800                1805


Ser Gly Lys Ser Ser Ser Leu Pro Ser Ser Ser Gly Asp Ser Ser Asn 
    1810                1815                1820


Leu Pro Asn Pro Pro Ala Thr Lys Pro Ser Ile Ala Ser Asn Pro Leu 
1825                1830                1835                1840


Ser Pro Gln Thr Gly Pro Pro Ala His Ser Ala Ser Leu Ile Pro Ser 
                1845                1850                1855


Val Ser Asn Gly Ser Leu Lys Phe Gln Ser Leu Thr His Thr Gly Lys 
            1860                1865                1870


Gly His His Leu Ser Phe Ser Pro Gln Ser Gln Asn Gly Arg Ala Pro 
        1875                1880                1885


Pro Pro Leu Ser Phe Ser Ser Ser Pro Pro Ser Pro Ala Ser Ser Val 
    1890                1895                1900


Ser Leu Asn Gln Gly Ala Lys Gly Thr Arg Thr Ile His Thr Pro Ser 
1905                1910                1915                1920


Leu Thr Ser Tyr Lys Ala Gln Asn Gly Ser Ser Ser Lys Ala Thr Pro 
                1925                1930                1935


Ser Thr Ala Lys Glu Thr Ser 
            1940


<210>  657
<211>  3096
<212>  DNA
<213>  Homo sapiens

<400>  657
cgggcgccca gagggcaaat gaggggcggc ggggtggcgg gtcgggggga gacgcggaat     60

ttcccagcgc gggggctctg gcttaccctg caaccgggca gtctctttct gtttacggag    120

agaaagggga aatggaaaag tcggggaggc ggtggctggc gtccgctgcg ccgcccctgg    180

gcaggctcag acgccgtgag tcaggggcag agcagggcgg tctgagcgtg cgggcgacgc    240

gggtctcact cgtccgctcc gctctggact gcgcgccacg ctctggggtc cggcgccctg    300

gttcctgctt ctgccgctgc cgccgccgga tcccagtggc ccggcgtgct cggctcccac    360

aggcctgcag ccagcatcgc accgaacctt cggggggccg cggctggagc gctcggccgg    420

cgtgggagcg ccaaggccgc agatgcaatc ttcttaccgc gaagaagcca ggggaatagg    480

tagccacatc ttgtttgcag ataagaaagg aagctaacgc agtatctgca aagccaggag    540

tctgactcag tacttttctc actcatgcat acaaagcagc taaaaatgac acagcttatt    600

taccatgccc ctgacactgc actgagcact ttatgagctt gaactctgtt aatcctcacg    660

accacctcat gagactctcc agaaagagca acagtaatgg agtacatgag cactggaagt    720

gacaataaag aagagattga tttattaatt aaacatttaa atgtgtctga tgtaatagac    780

attatggaaa atctttatgc aagtgaagag ccagcagttt atgaacccag tctaatgacc    840

atgtgtcaag acagtaatca aaacgatgag cgttctaagt ctctgctgct tagtggccaa    900

gaggtaccat ggttgtcatc agtcagatat ggaactgtgg aggatttgct tgcttttgca    960

aaccatatat ccaacactgc aaagcatttt tatggacaac gaccacagga atctggaatt   1020

ttattaaaca tggtcatcac tccccaaaat ggacgttacc aaatagattc cgatgttctc   1080

ctgatcccct ggaagctgac ttacaggaat attggttctg attttattcc tcggggcgcc   1140

tttggaaagg tatacttggc acaagatata aagacgaaga aaagaatggc gtgtaaactg   1200

atcccagtag atcaatttaa gccatctgat gtggaaatcc aggcttgctt ccggcacgag   1260

aacatcgcag agctgtatgg cgcagtcctg tggggtgaaa ctgtccatct ctttatggaa   1320

gcaggcgagg gagggtctgt tctggagaaa ctggagagct gtggaccaat gagagaattt   1380

gaaattattt gggtgacaaa gcatgttctc aagggacttg attttctaca ctcaaagaaa   1440

gtgatccatc atgatattaa acctagcaac attgttttca tgtccacaaa agctgttttg   1500

gtggattttg gcctaagtgt tcaaatgacc gaagatgtct attttcctaa ggacctccga   1560

ggaacagaga tttacatgag cccagaggtc atcctgtgca ggggccattc aaccaaagca   1620

gacatctaca gcctgggggc cacgctcatc cacatgcaga cgggcacccc accctgggtg   1680

aagcgctacc ctcgctcagc ctatccctcc tacctgtaca taatccacaa gcaagcacct   1740

ccactggaag acattgcaga tgactgcagt ccagggatga gagagctgat agaagcttcc   1800

ctggagagaa accccaatca ccgcccaaga gccgcagacc tactaaaaca tgaggccctg   1860

aacccgccca gagaggatca gccacgctgt cagagtctgg actctgccct cttggagcgc   1920

aagaggctgc tgagtaggaa ggagctggaa cttcctgaga acattgctga ttcttcgtgc   1980

acaggaagca ccgaggaatc tgagatgctc aagaggcaac gctctctcta catcgacctc   2040

ggcgctctgg ctggctactt caatcttgtt cggggaccac caacgcttga atatggctga   2100

aggatgccat gtttgctcta aattaagaca gcattgatct cctggaggct ggttctgctg   2160

cctctacaca ggggccctgt acagtgaatg gtgccatttt cgaaggagca gtgtgacctc   2220

ctgtgaccca tgaatgtgcc tccaagcggc cctgtgtgtt tgacatgtga agctatttga   2280

tatgcaccag gtctcaaggt tctcatttct caggtgacgt gattctaagg caggaatttg   2340

agagttcaca gaaggatcgt gtctgctgac tgtttcattc actgtgcact ttgctcaaaa   2400

ttttaaaaat accaatcaca aggataatag agtagcctaa aattactatt cttggttctt   2460

atttaagtat ggaatattca ttttactcag aatagctgtt ttgtgtatat tggtgtatat   2520

tatataactc tttgagcctt tattggtaaa ttctggtata cattgaattc attataattt   2580

gggtgactag aacaacttga agattgtagc aataagctgg actagtgtcc taaaaatggc   2640

taactgatga attagaagcc atctgacagc aggccactag tgacagtttc ttttgtgttc   2700

ctatggaaac attttatact gtacatgcta tgctgaagac attcaaaacg tgatgttttg   2760

aatgtggata aaactgtgta aaccacataa tttttgtaca tcccaaagga tgagaatgtg   2820

acctttaaga aaaatgaaaa cttttgtaaa ttattgatga ttttgtaatt cttatgacta   2880

aattttcttt taagcatttg tatattaaaa tagcatactg tgtatgtttt atatcaaatg   2940

ccttcatgaa tctttcatac atatatatat ttgtaacatt gtaaagtatg tgagtagtct   3000

tatgtaaagt atgtttttac attatgcaaa taaaacccaa tacttttgtc caatgtggtt   3060

ggtcaaatca actgaataaa ttcagtattt tgcctt                             3096


<210>  658
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  658

Met Glu Tyr Met Ser Thr Gly Ser Asp Asn Lys Glu Glu Ile Asp Leu 
1               5                   10                  15


Leu Ile Lys His Leu Asn Val Ser Asp Val Ile Asp Ile Met Glu Asn 
            20                  25                  30


Leu Tyr Ala Ser Glu Glu Pro Ala Val Tyr Glu Pro Ser Leu Met Thr 
        35                  40                  45


Met Cys Gln Asp Ser Asn Gln Asn Asp Glu Arg Ser Lys Ser Leu Leu 
    50                  55                  60


Leu Ser Gly Gln Glu Val Pro Trp Leu Ser Ser Val Arg Tyr Gly Thr 
65                  70                  75                  80


Val Glu Asp Leu Leu Ala Phe Ala Asn His Ile Ser Asn Thr Ala Lys 
                85                  90                  95


His Phe Tyr Gly Gln Arg Pro Gln Glu Ser Gly Ile Leu Leu Asn Met 
            100                 105                 110


Val Ile Thr Pro Gln Asn Gly Arg Tyr Gln Ile Asp Ser Asp Val Leu 
        115                 120                 125


Leu Ile Pro Trp Lys Leu Thr Tyr Arg Asn Ile Gly Ser Asp Phe Ile 
    130                 135                 140


Pro Arg Gly Ala Phe Gly Lys Val Tyr Leu Ala Gln Asp Ile Lys Thr 
145                 150                 155                 160


Lys Lys Arg Met Ala Cys Lys Leu Ile Pro Val Asp Gln Phe Lys Pro 
                165                 170                 175


Ser Asp Val Glu Ile Gln Ala Cys Phe Arg His Glu Asn Ile Ala Glu 
            180                 185                 190


Leu Tyr Gly Ala Val Leu Trp Gly Glu Thr Val His Leu Phe Met Glu 
        195                 200                 205


Ala Gly Glu Gly Gly Ser Val Leu Glu Lys Leu Glu Ser Cys Gly Pro 
    210                 215                 220


Met Arg Glu Phe Glu Ile Ile Trp Val Thr Lys His Val Leu Lys Gly 
225                 230                 235                 240


Leu Asp Phe Leu His Ser Lys Lys Val Ile His His Asp Ile Lys Pro 
                245                 250                 255


Ser Asn Ile Val Phe Met Ser Thr Lys Ala Val Leu Val Asp Phe Gly 
            260                 265                 270


Leu Ser Val Gln Met Thr Glu Asp Val Tyr Phe Pro Lys Asp Leu Arg 
        275                 280                 285


Gly Thr Glu Ile Tyr Met Ser Pro Glu Val Ile Leu Cys Arg Gly His 
    290                 295                 300


Ser Thr Lys Ala Asp Ile Tyr Ser Leu Gly Ala Thr Leu Ile His Met 
305                 310                 315                 320


Gln Thr Gly Thr Pro Pro Trp Val Lys Arg Tyr Pro Arg Ser Ala Tyr 
                325                 330                 335


Pro Ser Tyr Leu Tyr Ile Ile His Lys Gln Ala Pro Pro Leu Glu Asp 
            340                 345                 350


Ile Ala Asp Asp Cys Ser Pro Gly Met Arg Glu Leu Ile Glu Ala Ser 
        355                 360                 365


Leu Glu Arg Asn Pro Asn His Arg Pro Arg Ala Ala Asp Leu Leu Lys 
    370                 375                 380


His Glu Ala Leu Asn Pro Pro Arg Glu Asp Gln Pro Arg Cys Gln Ser 
385                 390                 395                 400


Leu Asp Ser Ala Leu Leu Glu Arg Lys Arg Leu Leu Ser Arg Lys Glu 
                405                 410                 415


Leu Glu Leu Pro Glu Asn Ile Ala Asp Ser Ser Cys Thr Gly Ser Thr 
            420                 425                 430


Glu Glu Ser Glu Met Leu Lys Arg Gln Arg Ser Leu Tyr Ile Asp Leu 
        435                 440                 445


Gly Ala Leu Ala Gly Tyr Phe Asn Leu Val Arg Gly Pro Pro Thr Leu 
    450                 455                 460


Glu Tyr Gly 
465


<210>  659
<211>  2910
<212>  DNA
<213>  Homo sapiens

<400>  659
ggcggcggcc ggccggggag gcggcctcgg cgcacagtaa tggcagcgct gtgagcaggg     60

gaacgcgagc tgacagccgc cgccgccgcc gcctccgccc accttcctcg ccggggcttc    120

gtctttcact ccttcgggct gcctccccct ccccttgtcc cctgcccctt gccctgcttc    180

tgcagaagat ttcaacacta cacttgcaca atgtctttga aaccaagagt agtagatttt    240

gatgaaacat ggaacaaact tttgacgaca ataaaagccg tggtcatgtt ggaatacgtc    300

gaaagagcaa catggaatga ccgtttctca gatatctatg ctttatgtgt ggcctatcct    360

gaaccccttg gagaaagact ttatacagaa actaagattt ttttggaaaa tcatgttcgg    420

catttgcata agagagtttt ggagtcagaa gaacaagtac ttgttatgta tcataggtac    480

tgggaagaat acagcaaggg tgcagactat atggactgct tatataggta tctcaacacc    540

cagtttatta aaaagaataa attaacagaa gcggaccttc agtatggcta tggtggtgta    600

gatatgaatg aaccacttat ggaaatagga gagctagcat tggatatgtg gaggaaattg    660

atggttgaac cacttcaggc catccttatc cgaatgctgc tccgagaaat caaaaatgat    720

cgtggtggag aagacccaaa ccagaaagta atccatgggg ttattaactc ctttgttcat    780

gttgaacagt ataagaaaaa attcccctta aagttttatc aggaaatttt tgagtctccc    840

tttctgactg aaacaggaga gtattacaaa caagaagctt caaatttatt acaagaatca    900

aactgctcac agtatatgga aaaggttcta ggtagattaa aagatgaaga aattcgatgt    960

cgaaaatacc tacatccaag ttcatatact aaggtgattc atgaatgtca acaacgaatg   1020

gtagcagacc acttacagtt tttacatgca gaatgtcata atataattcg acaagagaaa   1080

aaaaatgaca tggcaaatat gtacgtctta ctccgtgctg tgtccactgg tttacctcat   1140

atgattcagg agctgcaaaa ccacatccat gatgagggcc ttcgagcaac cagcaacctt   1200

actcaggaaa acatgccaac actatttgtg gagtcagttt tggaagtgca tggtaaattt   1260

gttcagctta tcaacactgt tttgaatggt gatcagcatt ttatgagtgc gttggataag   1320

gcccttacgt cagttgtaaa ttacagagaa cctaagtctg tttgcaaagc acctgaactg   1380

cttgctaagt actgtgacaa cttactgaag aagtcagcga aagggatgac agagaatgaa   1440

gtggaagaca ggctcacgag cttcatcaca gtgttcaaat acattgatga caaggacgtc   1500

tttcaaaagt tctacgcaag aatgctggca aaacgtttaa ttcatgggtt atccatgtct   1560

atggactctg aagaagccat gatcaacaaa ttaaagcaag cctgtggtta tgagtttacc   1620

agcaagctac atcggatgta tacagatatg agtgtcagcg ctgatctcaa caataagttc   1680

aacaatttta tcaaaaacca agacacagta atagatttgg gaattagttt tcaaatatat   1740

gttctacagg ctggtgcgtg gcctcttact caggctcctt catctacgtt tgcaattccc   1800

caggaattag aaaaaagtgt acagatgttt gaattatttt atagccaaca tttcagtgga   1860

aggaaactta catggttaca ttatctgtgt acaggtgaag ttaaaatgaa ctatttgggc   1920

aaaccatatg tagccatggt tacaacatac caaatggcag ttcttcttgc ctttaacaac   1980

agtgaaactg tcagttataa agagcttcag gacagcactc agatgaatga aaaggaactg   2040

acaaaaacaa tcaaatcatt acttgatgtg aaaatgatta accatgattc agaaaaggaa   2100

gatattgatg cagaatcttc gttttcatta aatatgaact ttagcagtaa aagaacaaaa   2160

tttaaaatta ctacatcaat gcagaaagac acaccacaag aaatggagca gactagaagt   2220

gcagttgatg aggaccggaa aatgtatctc caagctgcta tagttcgtat catgaaagca   2280

cgaaaagtgc ttcggcacaa tgcccttatt caagaggtga ttagccagtc aagagctagg   2340

tttaatccca gtatcagcat gattaagaag tgtattgaag ttctgataga caaacaatac   2400

atagaacgca gccaggcgtc ggcagatgaa tacagctacg tcgcgtgatg tcgctctcct   2460

ccagcgtggt gtgagaagat cattgccatc accatttggt gtgttcctgt gggaaaaagc   2520

aggactgtgc ctccataatt tggtcatttg gcagcccctg ttttctgctg tttacaacat   2580

caccagtgcc acgtcatgag cgtcaaagaa aatgcctaga gatatttcaa gctcatgtca   2640

ttatgacatt tcttaaaact ttattaaaag aatgagtgaa gtattgctga aaagtggaaa   2700

ttcggttggg taccatgctt tttctcccct tcacgtttgc agttgatgtg tctttttttt   2760

tttttttaat gtatcttaaa ggacataaaa tttaaaaact taaatattgt aatatgacag   2820

ataacctaat aattgtatct acattaaaat gacaaacatg atactgctgc ttgtcaaata   2880

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                                    2910


<210>  660
<211>  745
<212>  PRT
<213>  Homo sapiens

<400>  660

Met Ser Leu Lys Pro Arg Val Val Asp Phe Asp Glu Thr Trp Asn Lys 
1               5                   10                  15


Leu Leu Thr Thr Ile Lys Ala Val Val Met Leu Glu Tyr Val Glu Arg 
            20                  25                  30


Ala Thr Trp Asn Asp Arg Phe Ser Asp Ile Tyr Ala Leu Cys Val Ala 
        35                  40                  45


Tyr Pro Glu Pro Leu Gly Glu Arg Leu Tyr Thr Glu Thr Lys Ile Phe 
    50                  55                  60


Leu Glu Asn His Val Arg His Leu His Lys Arg Val Leu Glu Ser Glu 
65                  70                  75                  80


Glu Gln Val Leu Val Met Tyr His Arg Tyr Trp Glu Glu Tyr Ser Lys 
                85                  90                  95


Gly Ala Asp Tyr Met Asp Cys Leu Tyr Arg Tyr Leu Asn Thr Gln Phe 
            100                 105                 110


Ile Lys Lys Asn Lys Leu Thr Glu Ala Asp Leu Gln Tyr Gly Tyr Gly 
        115                 120                 125


Gly Val Asp Met Asn Glu Pro Leu Met Glu Ile Gly Glu Leu Ala Leu 
    130                 135                 140


Asp Met Trp Arg Lys Leu Met Val Glu Pro Leu Gln Ala Ile Leu Ile 
145                 150                 155                 160


Arg Met Leu Leu Arg Glu Ile Lys Asn Asp Arg Gly Gly Glu Asp Pro 
                165                 170                 175


Asn Gln Lys Val Ile His Gly Val Ile Asn Ser Phe Val His Val Glu 
            180                 185                 190


Gln Tyr Lys Lys Lys Phe Pro Leu Lys Phe Tyr Gln Glu Ile Phe Glu 
        195                 200                 205


Ser Pro Phe Leu Thr Glu Thr Gly Glu Tyr Tyr Lys Gln Glu Ala Ser 
    210                 215                 220


Asn Leu Leu Gln Glu Ser Asn Cys Ser Gln Tyr Met Glu Lys Val Leu 
225                 230                 235                 240


Gly Arg Leu Lys Asp Glu Glu Ile Arg Cys Arg Lys Tyr Leu His Pro 
                245                 250                 255


Ser Ser Tyr Thr Lys Val Ile His Glu Cys Gln Gln Arg Met Val Ala 
            260                 265                 270


Asp His Leu Gln Phe Leu His Ala Glu Cys His Asn Ile Ile Arg Gln 
        275                 280                 285


Glu Lys Lys Asn Asp Met Ala Asn Met Tyr Val Leu Leu Arg Ala Val 
    290                 295                 300


Ser Thr Gly Leu Pro His Met Ile Gln Glu Leu Gln Asn His Ile His 
305                 310                 315                 320


Asp Glu Gly Leu Arg Ala Thr Ser Asn Leu Thr Gln Glu Asn Met Pro 
                325                 330                 335


Thr Leu Phe Val Glu Ser Val Leu Glu Val His Gly Lys Phe Val Gln 
            340                 345                 350


Leu Ile Asn Thr Val Leu Asn Gly Asp Gln His Phe Met Ser Ala Leu 
        355                 360                 365


Asp Lys Ala Leu Thr Ser Val Val Asn Tyr Arg Glu Pro Lys Ser Val 
    370                 375                 380


Cys Lys Ala Pro Glu Leu Leu Ala Lys Tyr Cys Asp Asn Leu Leu Lys 
385                 390                 395                 400


Lys Ser Ala Lys Gly Met Thr Glu Asn Glu Val Glu Asp Arg Leu Thr 
                405                 410                 415


Ser Phe Ile Thr Val Phe Lys Tyr Ile Asp Asp Lys Asp Val Phe Gln 
            420                 425                 430


Lys Phe Tyr Ala Arg Met Leu Ala Lys Arg Leu Ile His Gly Leu Ser 
        435                 440                 445


Met Ser Met Asp Ser Glu Glu Ala Met Ile Asn Lys Leu Lys Gln Ala 
    450                 455                 460


Cys Gly Tyr Glu Phe Thr Ser Lys Leu His Arg Met Tyr Thr Asp Met 
465                 470                 475                 480


Ser Val Ser Ala Asp Leu Asn Asn Lys Phe Asn Asn Phe Ile Lys Asn 
                485                 490                 495


Gln Asp Thr Val Ile Asp Leu Gly Ile Ser Phe Gln Ile Tyr Val Leu 
            500                 505                 510


Gln Ala Gly Ala Trp Pro Leu Thr Gln Ala Pro Ser Ser Thr Phe Ala 
        515                 520                 525


Ile Pro Gln Glu Leu Glu Lys Ser Val Gln Met Phe Glu Leu Phe Tyr 
    530                 535                 540


Ser Gln His Phe Ser Gly Arg Lys Leu Thr Trp Leu His Tyr Leu Cys 
545                 550                 555                 560


Thr Gly Glu Val Lys Met Asn Tyr Leu Gly Lys Pro Tyr Val Ala Met 
                565                 570                 575


Val Thr Thr Tyr Gln Met Ala Val Leu Leu Ala Phe Asn Asn Ser Glu 
            580                 585                 590


Thr Val Ser Tyr Lys Glu Leu Gln Asp Ser Thr Gln Met Asn Glu Lys 
        595                 600                 605


Glu Leu Thr Lys Thr Ile Lys Ser Leu Leu Asp Val Lys Met Ile Asn 
    610                 615                 620


His Asp Ser Glu Lys Glu Asp Ile Asp Ala Glu Ser Ser Phe Ser Leu 
625                 630                 635                 640


Asn Met Asn Phe Ser Ser Lys Arg Thr Lys Phe Lys Ile Thr Thr Ser 
                645                 650                 655


Met Gln Lys Asp Thr Pro Gln Glu Met Glu Gln Thr Arg Ser Ala Val 
            660                 665                 670


Asp Glu Asp Arg Lys Met Tyr Leu Gln Ala Ala Ile Val Arg Ile Met 
        675                 680                 685


Lys Ala Arg Lys Val Leu Arg His Asn Ala Leu Ile Gln Glu Val Ile 
    690                 695                 700


Ser Gln Ser Arg Ala Arg Phe Asn Pro Ser Ile Ser Met Ile Lys Lys 
705                 710                 715                 720


Cys Ile Glu Val Leu Ile Asp Lys Gln Tyr Ile Glu Arg Ser Gln Ala 
                725                 730                 735


Ser Ala Asp Glu Tyr Ser Tyr Val Ala 
            740                 745


<210>  661
<211>  1005
<212>  DNA
<213>  Homo sapiens

<400>  661
atggtaggga atggtccaga ctctctagag ggaaaatggg gccgcgggag aggcggccaa     60

gatcgggttg gggaggcccg ggatccagtc cagggggtgg cagggcttac gggtcagcgc    120

tctggggagc cgaggtcact tacaggatac catcttcccg ggcctccccc tttcatccct    180

ctccccacac ctcgtcgccc ccaactcctc tcctccgccc cagccccgcc acccattaac    240

cgggaaggga agtttcccgg cgcctgcagc ccggctcccc gaccctcagc ggggttacct    300

tctgcagaag cagggcaagg ggcaggggac aaggggaggg ggaggcagcc cgaaggagtg    360

aaagacgaag ccccggcgag gaaggtgggc ggaggcggcg gcggcggcgg ctgtcagctc    420

gcgttcccct gctcacagcg ctgccattac tgtgcgccga ggccgcctcc ccggccggcc    480

gccgccaccg gccccggaga cgcggggggt ggggagcgaa gcccggggag cccgcgcgcc    540

gacactcacc tgtctccgcg aggaaagaca gcaaagtcca aggccgccgc cgctccccgg    600

cgggacaggg gcggtaggga gggggggaaa ggggagaagg acgggccgat cacgggatcc    660

gtaaaacaat cgtcctcctc tgcctccggc tttgcccaac acacaccctc cggtctcctt    720

cttccgctgc tgccaaatcc cccccgccac ccggaaagca atggtacagg ccgcgttacg    780

ggggcggagt tcgagcctgg atttttttcc tcggggcctc ccccgggagg ccgtcccggc    840

gtgggggagg ggaggacggg gcgggaggac gcggttcggt cggctgcagc gctacttttg    900

gtccggggtc ggcagggagg ccgcggctac cgcatcacag ctgacgtgag gactacgtgg    960

ggccgctgcc ggctccgggt tgctgggcgg cggcgccgct gctga                   1005


<210>  662
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  662

Met Val Gly Asn Gly Pro Asp Ser Leu Glu Gly Lys Trp Gly Arg Gly 
1               5                   10                  15


Arg Gly Gly Gln Asp Arg Val Gly Glu Ala Arg Asp Pro Val Gln Gly 
            20                  25                  30


Val Ala Gly Leu Thr Gly Gln Arg Ser Gly Glu Pro Arg Ser Leu Thr 
        35                  40                  45


Gly Tyr His Leu Pro Gly Pro Pro Pro Phe Ile Pro Leu Pro Thr Pro 
    50                  55                  60


Arg Arg Pro Gln Leu Leu Ser Ser Ala Pro Ala Pro Pro Pro Ile Asn 
65                  70                  75                  80


Arg Glu Gly Lys Phe Pro Gly Ala Cys Ser Pro Ala Pro Arg Pro Ser 
                85                  90                  95


Ala Gly Leu Pro Ser Ala Glu Ala Gly Gln Gly Ala Gly Asp Lys Gly 
            100                 105                 110


Arg Gly Arg Gln Pro Glu Gly Val Lys Asp Glu Ala Pro Ala Arg Lys 
        115                 120                 125


Val Gly Gly Gly Gly Gly Gly Gly Gly Cys Gln Leu Ala Phe Pro Cys 
    130                 135                 140


Ser Gln Arg Cys His Tyr Cys Ala Pro Arg Pro Pro Pro Arg Pro Ala 
145                 150                 155                 160


Ala Ala Thr Gly Pro Gly Asp Ala Gly Gly Gly Glu Arg Ser Pro Gly 
                165                 170                 175


Ser Pro Arg Ala Asp Thr His Leu Ser Pro Arg Gly Lys Thr Ala Lys 
            180                 185                 190


Ser Lys Ala Ala Ala Ala Pro Arg Arg Asp Arg Gly Gly Arg Glu Gly 
        195                 200                 205


Gly Lys Gly Glu Lys Asp Gly Pro Ile Thr Gly Ser Val Lys Gln Ser 
    210                 215                 220


Ser Ser Ser Ala Ser Gly Phe Ala Gln His Thr Pro Ser Gly Leu Leu 
225                 230                 235                 240


Leu Pro Leu Leu Pro Asn Pro Pro Arg His Pro Glu Ser Asn Gly Thr 
                245                 250                 255


Gly Arg Val Thr Gly Ala Glu Phe Glu Pro Gly Phe Phe Ser Ser Gly 
            260                 265                 270


Pro Pro Pro Gly Gly Arg Pro Gly Val Gly Glu Gly Arg Thr Gly Arg 
        275                 280                 285


Glu Asp Ala Val Arg Ser Ala Ala Ala Leu Leu Leu Val Arg Gly Arg 
    290                 295                 300


Gln Gly Gly Arg Gly Tyr Arg Ile Thr Ala Asp Val Arg Thr Thr Trp 
305                 310                 315                 320


Gly Arg Cys Arg Leu Arg Val Ala Gly Arg Arg Arg Arg Cys 
                325                 330


<210>  663
<211>  1308
<212>  DNA
<213>  Homo sapiens

<400>  663
gctggcggcc ggcagggggc ggagttcgag cctggatttt tttcctcggg gcctcccccg     60

ggaggccgtc ccggcgtggg ggaggggagg acggggcggg aggacgcggt tcggtcggct    120

gcagcgctac ttttggtccg gggtcggcag ggaggccgcg gctaccgcat cacagctgac    180

gtgaggacta cgtggggccg ctgccggctc cgggttgctg ggcggcggcg ccgctgctga    240

gcggcggtcg ggctcgccgt ctccacctcc tcgcgtccgt aatcagtgac gaggtccgct    300

acgtaaatcc ctttgcggcg gacaaatgac catggaaaca gttgaatccc agcatgatgg    360

aagtataaca gcttctttga cagagagcaa gtctgctcat gtgcagactc agactggcca    420

aaattcaatc cctgctttag ctcaggtagc agcaattgca gagacagatg aatctgcaga    480

atcagaaggt gtaattgatt ctcataaacg tagagaaatc ctttcacgaa gaccctctta    540

taggaaaata ctgaatgaac tgtcctctga tgtgcctggt gttcccaaga ttgaagaaga    600

gagatcagag gaagaaggaa caccacctag tattgctacc atggcagtac caactagcat    660

atatcagact agcacggggc aatacagtat gtatgctgca attcgatatg atacagtgct    720

agctttaagt cttctctagt tatattgaag caactcaggt tttggcatta aattgttcca    780

ttttaaaatg catcattaat acctaaactg tatcatagaa tgaaagtata tgttaaaaag    840

tgagatcttt gtattgacag ctgtcatata attttgaaaa gtaaaaattt tgactgccga    900

atatagaaga aaattttggg gtaaaaagga gaatttttcc tatttacatg tttatattaa    960

tctctagtaa aacattgttt ttgttgtctt tatgatgcat gcgaacataa atgtctgtat   1020

ttcattcttg ttggcttttg ttacccacaa ttacatacta ttcttactaa tctgagagtt   1080

ttctaaagta tgttttcaat gtttcactac tctctactct gttaatttgt gctacagttt   1140

ttcctaaaag agaatggaaa aatgatttaa ttttttaaac tgtagcaatt ggatagataa   1200

ttttatttga aattttacac actgaaagct ctaaataaac agatacattc acattcaaaa   1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                1308


<210>  664
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  664

Met Thr Met Glu Thr Val Glu Ser Gln His Asp Gly Ser Ile Thr Ala 
1               5                   10                  15


Ser Leu Thr Glu Ser Lys Ser Ala His Val Gln Thr Gln Thr Gly Gln 
            20                  25                  30


Asn Ser Ile Pro Ala Leu Ala Gln Val Ala Ala Ile Ala Glu Thr Asp 
        35                  40                  45


Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg Glu 
    50                  55                  60


Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu Ser 
65                  70                  75                  80


Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu Glu 
                85                  90                  95


Glu Gly Thr Pro Pro Ser Ile Ala Thr Met Ala Val Pro Thr Ser Ile 
            100                 105                 110


Tyr Gln Thr Ser Thr Gly Gln Tyr Ser Met Tyr Ala Ala Ile Arg Tyr 
        115                 120                 125


Asp Thr Val Leu Ala Leu Ser Leu Leu 
    130                 135


<210>  665
<211>  2225
<212>  DNA
<213>  Homo sapiens

<400>  665
gacccgcctg cctcctcgcg aacttgggac gagttggaaa atcctccctg agagagccgt     60

gcggctcagg ggagcggttt aactcggaaa aggaaaagga atccagaaga taaataaaga    120

aaacaggaaa ggaggaaagc attgattaca aatatcttaa caatgagcaa atgtgcaagg    180

aaaaaatata ttaagacaaa tccaagacaa atgaccatgg aaacagttga atcccagcat    240

gatggaagta taacagcttc tttgacagag agcaagtctg ctcatgtgca gactcagact    300

ggccaaaatt caatccctgc tttagctcag gtagcagcaa ttgcagagac agatgaatct    360

gcagaatcag aaggtgtaat tgattctcat aaacgtagag aaatcctttc acgaagaccc    420

tcttatagga aaatactgaa tgaactgtcc tctgatgtgc ctggtgttcc caagattgaa    480

gaagagagat cagaggaaga aggaacacca cctagtattg ctaccatggc agtaccaact    540

agcatatatc agactagcac ggggcaatac attgctatag cccaaggtgg aacaatccag    600

atttctaacc caggatctga tggtgttcag ggactgcagg cattaacaat gacaaattca    660

ggagctcctc caccaggtgc tacaattgta cagtacgcag cacaatcagc tgatggcaca    720

cagcagttct ttgtcccagg cagccaggtt gttgttcaag ctgccactgg tgacatgcca    780

acttaccaga tccgagctcc tactgctgct ttgccacagg gagtggtgat ggctgcatcg    840

cccggaagtt tgcacagtcc ccagcagctg gcagaagaag caacacgcaa acgagagctg    900

aggctaatga aaaacaggga agctgccaaa gaatgtcgac gtcgaaagaa agaatatgta    960

aaatgtctgg agagccgagt tgcagtgctg gaagtccaga acaagaagct tatagaggaa   1020

cttgaaacct tgaaagacat ttgttctccc aaaacagatt actagaaata tttaactatg   1080

aactgaaggc agcatgtata gttgcttttg aaggaataca atatatagct ggcaagaatg   1140

gtggcttctt ttctttgtat cattcatctt cttctttaat cacttaacat tcctaaaatg   1200

cttcactgta cgtagttaag tcgtagctat aacttcaaat tttttaaaag agacaaactg   1260

taaaaaatgt gtgtattctt aaaatgcaat atttgtaagg cttgttccaa tgccacatac   1320

ttgcagctcc cattctatgt gtcatcaata gtgtcctatg caataaaatt atttgcaggt   1380

ctttaaatca ttttaggaaa ggatgatcaa aaataatgca tccagcagta caataaaagt   1440

aaaccacaaa aaaatacctc aggaaagaat agaaagaaag tctatctaat gacatgccta   1500

tatgagaaga atagcctaga tatgaatata tggcatttgc agatttttat attagttgct   1560

ttgttaaaaa aaaaaagatt gtattgctgt ccttgaatgc catagtcaaa gagagttttt   1620

aatagaacca tgttggttgc actttgtagt gtttggtgct catttaaata tctgaacatt   1680

tactacagtt tttaactcta ctgtgtaata taaaagatct tgcagaagtt cttagtgttg   1740

gtttaatatt acctaatgaa agtgatgaca tattttttat atctggaatg agcctgttgg   1800

gatcgcattg cataccttcg gggtacaagt cagtttctac actgggtgct gatccttgca   1860

cgcgcccttt ctaccatctc acggtgggga tggccgcagg gctgtgcacc cagaagaaga   1920

tggctgttag cgtttcggcc ttcataatgg cctgagactt tctttctgta ggtggtctgg   1980

agctgtccgg ctggtggccc cctattttgc catttagcga acaaccacag gaattttaaa   2040

aacaaaaaca tcccaagatt ttttcatttc aaaatgcttc aaagtccaca ttagatcaga   2100

tactccgctg tcggcacatt cagctgaggt tcattacaat cgagactgca atgtgatcta   2160

tgtttcatct tgtttttata ataaaaagct tcagggaaca agcccaaagc cctcaccaca   2220

aaaaa                                                               2225


<210>  666
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  666

Met Ser Lys Cys Ala Arg Lys Lys Tyr Ile Lys Thr Asn Pro Arg Gln 
1               5                   10                  15


Met Thr Met Glu Thr Val Glu Ser Gln His Asp Gly Ser Ile Thr Ala 
            20                  25                  30


Ser Leu Thr Glu Ser Lys Ser Ala His Val Gln Thr Gln Thr Gly Gln 
        35                  40                  45


Asn Ser Ile Pro Ala Leu Ala Gln Val Ala Ala Ile Ala Glu Thr Asp 
    50                  55                  60


Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg Glu 
65                  70                  75                  80


Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu Ser 
                85                  90                  95


Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu Glu 
            100                 105                 110


Glu Gly Thr Pro Pro Ser Ile Ala Thr Met Ala Val Pro Thr Ser Ile 
        115                 120                 125


Tyr Gln Thr Ser Thr Gly Gln Tyr Ile Ala Ile Ala Gln Gly Gly Thr 
    130                 135                 140


Ile Gln Ile Ser Asn Pro Gly Ser Asp Gly Val Gln Gly Leu Gln Ala 
145                 150                 155                 160


Leu Thr Met Thr Asn Ser Gly Ala Pro Pro Pro Gly Ala Thr Ile Val 
                165                 170                 175


Gln Tyr Ala Ala Gln Ser Ala Asp Gly Thr Gln Gln Phe Phe Val Pro 
            180                 185                 190


Gly Ser Gln Val Val Val Gln Ala Ala Thr Gly Asp Met Pro Thr Tyr 
        195                 200                 205


Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met Ala 
    210                 215                 220


Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala 
225                 230                 235                 240


Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Lys 
                245                 250                 255


Glu Cys Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser Arg 
            260                 265                 270


Val Ala Val Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu Glu 
        275                 280                 285


Thr Leu Lys Asp Ile Cys Ser Pro Lys Thr Asp Tyr 
    290                 295                 300


<210>  667
<211>  1991
<212>  DNA
<213>  Homo sapiens

<400>  667
tggaacactt tatgttgaac tgtggtagag gaaacaagac agttctgtct gcagaagccc     60

attatggctg taactggaga tgacacagat gaggaaactg aacttgcccc aagtcacatg    120

gctgctgcca ctggtgacat gccaacttac cagatccgag ctcctactgc tgctttgcca    180

cagggagtgg tgatggctgc atcgcccgga agtttgcaca gtccccagca gctggcagaa    240

gaagcaacac gcaaacgaga gctgaggcta atgaaaaaca gggaagctgc ccgggagtgt    300

cgcaggaaga agaaagaata tgtcaaatgt cttgaaaatc gtgtggctgt gcttgaaaac    360

caaaacaaga ctctcattga ggaactcaag gccctcaaag atctttattg ccataaagta    420

gagtaactgt ctttgacttg gaccttgttt actctaatca aggcaggaga tgcagcagtc    480

ctacttattg ccatgtggac ttgtgggaag gacacgtgtg acccttaaga atccagtttg    540

gattagtgtt tgaaattgaa ttgggaatgt tgttccagga tgtggaatgc agccgtgatc    600

acacttaccg agcttacttt gatctgtttg tcaatagcat gcaaaaaatg ctttgtttgc    660

cctttgcttc tgcttttttt cagggaagct gccaaagaat gtcgacgtcg aaagaaagaa    720

tatgtaaaat gtctggagag ccgagttgca gtgctggaag tccagaacaa gaagcttata    780

gaggaacttg aaaccttgaa agacatttgt tctcccaaaa cagattacta gaaatattta    840

actatgaact gaaggcagca tgtatagttg cttttgaagg aatacaatat atagctggca    900

agaatggtgg cttcttttct ttgtatcatt catcttcttc tttaatcact taacattcct    960

aaaatgcttc actgtacgta gttaagtcgt agctataact tcaaattttt taaaagagac   1020

aaactgtaaa aaatgtgtgt attcttaaaa tgcaatattt gtaaggcttg ttccaatgcc   1080

acatacttgc agctcccatt ctatgtgtca tcaatagtgt cctatgcaat aaaattattt   1140

gcaggtcttt aaatcatttt aggaaaggat gatcaaaaat aatgcatcca gcagtacaat   1200

aaaagtaaac cacaaaaaaa tacctcagga aagaatagaa agaaagtcta tctaatgaca   1260

tgcctatatg agaagaatag cctagatatg aatatatggc atttgcagat ttttatatta   1320

gttgctttgt taaaaaaaaa aagattgtat tgctgtcctt gaatgccata gtcaaagaga   1380

gtttttaata gaaccatgtt ggttgcactt tgtagtgttt ggtgctcatt taaatatctg   1440

aacatttact acagttttta actctactgt gtaatataaa agatcttgca gaagttctta   1500

gtgttggttt aatattacct aatgaaagtg atgacatatt ttttatatct ggaatgagcc   1560

tgttgggatc gcattgcata ccttcggggt acaagtcagt ttctacactg ggtgctgatc   1620

cttgcacgcg ccctttctac catctcacgg tggggatggc cgcagggctg tgcacccaga   1680

agaagatggc tgttagcgtt tcggccttca taatggcctg agactttctt tctgtaggtg   1740

gtctggagct gtccggctgg tggcccccta ttttgccatt tagcgaacaa ccacaggaat   1800

tttaaaaaca aaaacatccc aagatttttt catttcaaaa tgcttcaaag tccacattag   1860

atcagatact ccgctgtcgg cacattcagc tgaggttcat tacaatcgag actgcaatgt   1920

gatctatgtt tcatcttgtt tttataataa aaagcttcag ggaacaagcc caaagccctc   1980

accacaaaaa a                                                        1991


<210>  668
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  668

Met Ala Val Thr Gly Asp Asp Thr Asp Glu Glu Thr Glu Leu Ala Pro 
1               5                   10                  15


Ser His Met Ala Ala Ala Thr Gly Asp Met Pro Thr Tyr Gln Ile Arg 
            20                  25                  30


Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser Pro 
        35                  40                  45


Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala Thr Arg Lys 
    50                  55                  60


Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Arg Glu Cys Arg 
65                  70                  75                  80


Arg Lys Lys Lys Glu Tyr Val Lys Cys Leu Glu Asn Arg Val Ala Val 
                85                  90                  95


Leu Glu Asn Gln Asn Lys Thr Leu Ile Glu Glu Leu Lys Ala Leu Lys 
            100                 105                 110


Asp Leu Tyr Cys His Lys Val Glu 
        115                 120


<210>  669
<211>  1553
<212>  DNA
<213>  Homo sapiens

<400>  669
tggaacactt tatgttgaac tgtggtagag gaaacaagac agttctgtct gcagaagccc     60

attatggctg taactggaga tgacacagct gccactggtg acatgccaac ttaccagatc    120

cgagctccta ctgctgcttt gccacaggga gtggtgatgg ctgcatcgcc cggaagtttg    180

cacagtcccc agcagctggc agaagaagca acacgcaaac gagagctgag gctaatgaaa    240

aacagggaag ctgccaaaga atgtcgacgt cgaaagaaag aatatgtaaa atgtctggag    300

agccgagttg cagtgctgga agtccagaac aagaagctta tagaggaact tgaaaccttg    360

aaagacattt gttctcccaa aacagattac tagaaatatt taactatgaa ctgaaggcag    420

catgtatagt tgcttttgaa ggaatacaat atatagctgg caagaatggt ggcttctttt    480

ctttgtatca ttcatcttct tctttaatca cttaacattc ctaaaatgct tcactgtacg    540

tagttaagtc gtagctataa cttcaaattt tttaaaagag acaaactgta aaaaatgtgt    600

gtattcttaa aatgcaatat ttgtaaggct tgttccaatg ccacatactt gcagctccca    660

ttctatgtgt catcaatagt gtcctatgca ataaaattat ttgcaggtct ttaaatcatt    720

ttaggaaagg atgatcaaaa ataatgcatc cagcagtaca ataaaagtaa accacaaaaa    780

aatacctcag gaaagaatag aaagaaagtc tatctaatga catgcctata tgagaagaat    840

agcctagata tgaatatatg gcatttgcag atttttatat tagttgcttt gttaaaaaaa    900

aaaagattgt attgctgtcc ttgaatgcca tagtcaaaga gagtttttaa tagaaccatg    960

ttggttgcac tttgtagtgt ttggtgctca tttaaatatc tgaacattta ctacagtttt   1020

taactctact gtgtaatata aaagatcttg cagaagttct tagtgttggt ttaatattac   1080

ctaatgaaag tgatgacata ttttttatat ctggaatgag cctgttggga tcgcattgca   1140

taccttcggg gtacaagtca gtttctacac tgggtgctga tccttgcacg cgccctttct   1200

accatctcac ggtggggatg gccgcagggc tgtgcaccca gaagaagatg gctgttagcg   1260

tttcggcctt cataatggcc tgagactttc tttctgtagg tggtctggag ctgtccggct   1320

ggtggccccc tattttgcca tttagcgaac aaccacagga attttaaaaa caaaaacatc   1380

ccaagatttt ttcatttcaa aatgcttcaa agtccacatt agatcagata ctccgctgtc   1440

ggcacattca gctgaggttc attacaatcg agactgcaat gtgatctatg tttcatcttg   1500

tttttataat aaaaagcttc agggaacaag cccaaagccc tcaccacaaa aaa          1553


<210>  670
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  670

Met Ala Val Thr Gly Asp Asp Thr Ala Ala Thr Gly Asp Met Pro Thr 
1               5                   10                  15


Tyr Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met 
            20                  25                  30


Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu 
        35                  40                  45


Ala Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala 
    50                  55                  60


Lys Glu Cys Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser 
65                  70                  75                  80


Arg Val Ala Val Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu 
                85                  90                  95


Glu Thr Leu Lys Asp Ile Cys Ser Pro Lys Thr Asp Tyr 
            100                 105


<210>  671
<211>  1589
<212>  DNA
<213>  Homo sapiens

<400>  671
tggaacactt tatgttgaac tgtggtagag gaaacaagac agttctgtct gcagaagccc     60

attatggctg taactggaga tgacacagat gaggaaactg aacttgcccc aagtcacatg    120

gctgctgcca ctggtgacat gccaacttac cagatccgag ctcctactgc tgctttgcca    180

cagggagtgg tgatggctgc atcgcccgga agtttgcaca gtccccagca gctggcagaa    240

gaagcaacac gcaaacgaga gctgaggcta atgaaaaaca gggaagctgc caaagaatgt    300

cgacgtcgaa agaaagaata tgtaaaatgt ctggagagcc gagttgcagt gctggaagtc    360

cagaacaaga agcttataga ggaacttgaa accttgaaag acatttgttc tcccaaaaca    420

gattactaga aatatttaac tatgaactga aggcagcatg tatagttgct tttgaaggaa    480

tacaatatat agctggcaag aatggtggct tcttttcttt gtatcattca tcttcttctt    540

taatcactta acattcctaa aatgcttcac tgtacgtagt taagtcgtag ctataacttc    600

aaatttttta aaagagacaa actgtaaaaa atgtgtgtat tcttaaaatg caatatttgt    660

aaggcttgtt ccaatgccac atacttgcag ctcccattct atgtgtcatc aatagtgtcc    720

tatgcaataa aattatttgc aggtctttaa atcattttag gaaaggatga tcaaaaataa    780

tgcatccagc agtacaataa aagtaaacca caaaaaaata cctcaggaaa gaatagaaag    840

aaagtctatc taatgacatg cctatatgag aagaatagcc tagatatgaa tatatggcat    900

ttgcagattt ttatattagt tgctttgtta aaaaaaaaaa gattgtattg ctgtccttga    960

atgccatagt caaagagagt ttttaataga accatgttgg ttgcactttg tagtgtttgg   1020

tgctcattta aatatctgaa catttactac agtttttaac tctactgtgt aatataaaag   1080

atcttgcaga agttcttagt gttggtttaa tattacctaa tgaaagtgat gacatatttt   1140

ttatatctgg aatgagcctg ttgggatcgc attgcatacc ttcggggtac aagtcagttt   1200

ctacactggg tgctgatcct tgcacgcgcc ctttctacca tctcacggtg gggatggccg   1260

cagggctgtg cacccagaag aagatggctg ttagcgtttc ggccttcata atggcctgag   1320

actttctttc tgtaggtggt ctggagctgt ccggctggtg gccccctatt ttgccattta   1380

gcgaacaacc acaggaattt taaaaacaaa aacatcccaa gattttttca tttcaaaatg   1440

cttcaaagtc cacattagat cagatactcc gctgtcggca cattcagctg aggttcatta   1500

caatcgagac tgcaatgtga tctatgtttc atcttgtttt tataataaaa agcttcaggg   1560

aacaagccca aagccctcac cacaaaaaa                                     1589


<210>  672
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  672

Met Ala Val Thr Gly Asp Asp Thr Asp Glu Glu Thr Glu Leu Ala Pro 
1               5                   10                  15


Ser His Met Ala Ala Ala Thr Gly Asp Met Pro Thr Tyr Gln Ile Arg 
            20                  25                  30


Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser Pro 
        35                  40                  45


Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala Thr Arg Lys 
    50                  55                  60


Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Lys Glu Cys Arg 
65                  70                  75                  80


Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser Arg Val Ala Val 
                85                  90                  95


Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu Glu Thr Leu Lys 
            100                 105                 110


Asp Ile Cys Ser Pro Lys Thr Asp Tyr 
        115                 120


<210>  673
<211>  1955
<212>  DNA
<213>  Homo sapiens

<400>  673
tggaacactt tatgttgaac tgtggtagag gaaacaagac agttctgtct gcagaagccc     60

attatggctg taactggaga tgacacagct gccactggtg acatgccaac ttaccagatc    120

cgagctccta ctgctgcttt gccacaggga gtggtgatgg ctgcatcgcc cggaagtttg    180

cacagtcccc agcagctggc agaagaagca acacgcaaac gagagctgag gctaatgaaa    240

aacagggaag ctgcccggga gtgtcgcagg aagaagaaag aatatgtcaa atgtcttgaa    300

aatcgtgtgg ctgtgcttga aaaccaaaac aagactctca ttgaggaact caaggccctc    360

aaagatcttt attgccataa agtagagtaa ctgtctttga cttggacctt gtttactcta    420

atcaaggcag gagatgcagc agtcctactt attgccatgt ggacttgtgg gaaggacacg    480

tgtgaccctt aagaatccag tttggattag tgtttgaaat tgaattggga atgttgttcc    540

aggatgtgga atgcagccgt gatcacactt accgagctta ctttgatctg tttgtcaata    600

gcatgcaaaa aatgctttgt ttgccctttg cttctgcttt ttttcaggga agctgccaaa    660

gaatgtcgac gtcgaaagaa agaatatgta aaatgtctgg agagccgagt tgcagtgctg    720

gaagtccaga acaagaagct tatagaggaa cttgaaacct tgaaagacat ttgttctccc    780

aaaacagatt actagaaata tttaactatg aactgaaggc agcatgtata gttgcttttg    840

aaggaataca atatatagct ggcaagaatg gtggcttctt ttctttgtat cattcatctt    900

cttctttaat cacttaacat tcctaaaatg cttcactgta cgtagttaag tcgtagctat    960

aacttcaaat tttttaaaag agacaaactg taaaaaatgt gtgtattctt aaaatgcaat   1020

atttgtaagg cttgttccaa tgccacatac ttgcagctcc cattctatgt gtcatcaata   1080

gtgtcctatg caataaaatt atttgcaggt ctttaaatca ttttaggaaa ggatgatcaa   1140

aaataatgca tccagcagta caataaaagt aaaccacaaa aaaatacctc aggaaagaat   1200

agaaagaaag tctatctaat gacatgccta tatgagaaga atagcctaga tatgaatata   1260

tggcatttgc agatttttat attagttgct ttgttaaaaa aaaaaagatt gtattgctgt   1320

ccttgaatgc catagtcaaa gagagttttt aatagaacca tgttggttgc actttgtagt   1380

gtttggtgct catttaaata tctgaacatt tactacagtt tttaactcta ctgtgtaata   1440

taaaagatct tgcagaagtt cttagtgttg gtttaatatt acctaatgaa agtgatgaca   1500

tattttttat atctggaatg agcctgttgg gatcgcattg cataccttcg gggtacaagt   1560

cagtttctac actgggtgct gatccttgca cgcgcccttt ctaccatctc acggtgggga   1620

tggccgcagg gctgtgcacc cagaagaaga tggctgttag cgtttcggcc ttcataatgg   1680

cctgagactt tctttctgta ggtggtctgg agctgtccgg ctggtggccc cctattttgc   1740

catttagcga acaaccacag gaattttaaa aacaaaaaca tcccaagatt ttttcatttc   1800

aaaatgcttc aaagtccaca ttagatcaga tactccgctg tcggcacatt cagctgaggt   1860

tcattacaat cgagactgca atgtgatcta tgtttcatct tgtttttata ataaaaagct   1920

tcagggaaca agcccaaagc cctcaccaca aaaaa                              1955


<210>  674
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  674

Met Ala Val Thr Gly Asp Asp Thr Ala Ala Thr Gly Asp Met Pro Thr 
1               5                   10                  15


Tyr Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met 
            20                  25                  30


Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu 
        35                  40                  45


Ala Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala 
    50                  55                  60


Arg Glu Cys Arg Arg Lys Lys Lys Glu Tyr Val Lys Cys Leu Glu Asn 
65                  70                  75                  80


Arg Val Ala Val Leu Glu Asn Gln Asn Lys Thr Leu Ile Glu Glu Leu 
                85                  90                  95


Lys Ala Leu Lys Asp Leu Tyr Cys His Lys Val Glu 
            100                 105


<210>  675
<211>  2065
<212>  DNA
<213>  Homo sapiens

<400>  675
gtaaaatgct gctgacagat ttagagttaa ctagctcacc actgcctctg cctccaagct     60

gccttttaga ctgaatagct tttcttgtta gccctacttt aacatttctt ttgaagtggt    120

tgtctgcttg aagagggaaa cacgtcatga aactgtaatg catgaacaga actcaggagt    180

tgtctggcca gcttagtgct gccactggtg acatgccaac ttaccagatc cgagctccta    240

ctgctgcttt gccacaggga gtggtgatgg ctgcatcgcc cggaagtttg cacagtcccc    300

agcagctggc agaagaagca acacgcaaac gagagctgag gctaatgaaa aacagggaag    360

ctgcccggga gtgtcgcagg aagaagaaag aatatgtcaa atgtcttgaa aatcgtgtgg    420

ctgtgcttga aaaccaaaac aagactctca ttgaggaact caaggccctc aaagatcttt    480

attgccataa agtagagtaa ctgtctttga cttggacctt gtttactcta atcaaggcag    540

gagatgcagc agtcctactt attgccatgt ggacttgtgg gaaggacacg tgtgaccctt    600

aagaatccag tttggattag tgtttgaaat tgaattggga atgttgttcc aggatgtgga    660

atgcagccgt gatcacactt accgagctta ctttgatctg tttgtcaata gcatgcaaaa    720

aatgctttgt ttgccctttg cttctgcttt ttttcaggga agctgccaaa gaatgtcgac    780

gtcgaaagaa agaatatgta aaatgtctgg agagccgagt tgcagtgctg gaagtccaga    840

acaagaagct tatagaggaa cttgaaacct tgaaagacat ttgttctccc aaaacagatt    900

actagaaata tttaactatg aactgaaggc agcatgtata gttgcttttg aaggaataca    960

atatatagct ggcaagaatg gtggcttctt ttctttgtat cattcatctt cttctttaat   1020

cacttaacat tcctaaaatg cttcactgta cgtagttaag tcgtagctat aacttcaaat   1080

tttttaaaag agacaaactg taaaaaatgt gtgtattctt aaaatgcaat atttgtaagg   1140

cttgttccaa tgccacatac ttgcagctcc cattctatgt gtcatcaata gtgtcctatg   1200

caataaaatt atttgcaggt ctttaaatca ttttaggaaa ggatgatcaa aaataatgca   1260

tccagcagta caataaaagt aaaccacaaa aaaatacctc aggaaagaat agaaagaaag   1320

tctatctaat gacatgccta tatgagaaga atagcctaga tatgaatata tggcatttgc   1380

agatttttat attagttgct ttgttaaaaa aaaaaagatt gtattgctgt ccttgaatgc   1440

catagtcaaa gagagttttt aatagaacca tgttggttgc actttgtagt gtttggtgct   1500

catttaaata tctgaacatt tactacagtt tttaactcta ctgtgtaata taaaagatct   1560

tgcagaagtt cttagtgttg gtttaatatt acctaatgaa agtgatgaca tattttttat   1620

atctggaatg agcctgttgg gatcgcattg cataccttcg gggtacaagt cagtttctac   1680

actgggtgct gatccttgca cgcgcccttt ctaccatctc acggtgggga tggccgcagg   1740

gctgtgcacc cagaagaaga tggctgttag cgtttcggcc ttcataatgg cctgagactt   1800

tctttctgta ggtggtctgg agctgtccgg ctggtggccc cctattttgc catttagcga   1860

acaaccacag gaattttaaa aacaaaaaca tcccaagatt ttttcatttc aaaatgcttc   1920

aaagtccaca ttagatcaga tactccgctg tcggcacatt cagctgaggt tcattacaat   1980

cgagactgca atgtgatcta tgtttcatct tgtttttata ataaaaagct tcagggaaca   2040

agcccaaagc cctcaccaca aaaaa                                         2065


<210>  676
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  676

Met Asn Arg Thr Gln Glu Leu Ser Gly Gln Leu Ser Ala Ala Thr Gly 
1               5                   10                  15


Asp Met Pro Thr Tyr Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln 
            20                  25                  30


Gly Val Val Met Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln 
        35                  40                  45


Leu Ala Glu Glu Ala Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn 
    50                  55                  60


Arg Glu Ala Ala Arg Glu Cys Arg Arg Lys Lys Lys Glu Tyr Val Lys 
65                  70                  75                  80


Cys Leu Glu Asn Arg Val Ala Val Leu Glu Asn Gln Asn Lys Thr Leu 
                85                  90                  95


Ile Glu Glu Leu Lys Ala Leu Lys Asp Leu Tyr Cys His Lys Val Glu 
            100                 105                 110


<210>  677
<211>  2108
<212>  DNA
<213>  Homo sapiens

<400>  677
gtaaaatgct gctgacagat ttagagttaa ctagctcacc actgcctctg cctccaagct     60

gccttttaga ctgaatagct tttcttgtta gccctacttt aacatttctt ttgaagtggt    120

tgtctgcttg aagagggaaa cacgtcatga aactgtaatg catgaacaga actcaggagt    180

tgtctggcca gcttagtggt aagatcgagc ctcctactga ggccgtccct gcatgcgcct    240

gctgccactg gtgacatgcc aacttaccag atccgagctc ctactgctgc tttgccacag    300

ggagtggtga tggctgcatc gcccggaagt ttgcacagtc cccagcagct ggcagaagaa    360

gcaacacgca aacgagagct gaggctaatg aaaaacaggg aagctgcccg ggagtgtcgc    420

aggaagaaga aagaatatgt caaatgtctt gaaaatcgtg tggctgtgct tgaaaaccaa    480

aacaagactc tcattgagga actcaaggcc ctcaaagatc tttattgcca taaagtagag    540

taactgtctt tgacttggac cttgtttact ctaatcaagg caggagatgc agcagtccta    600

cttattgcca tgtggacttg tgggaaggac acgtgtgacc cttaagaatc cagtttggat    660

tagtgtttga aattgaattg ggaatgttgt tccaggatgt ggaatgcagc cgtgatcaca    720

cttaccgagc ttactttgat ctgtttgtca atagcatgca aaaaatgctt tgtttgccct    780

ttgcttctgc tttttttcag ggaagctgcc aaagaatgtc gacgtcgaaa gaaagaatat    840

gtaaaatgtc tggagagccg agttgcagtg ctggaagtcc agaacaagaa gcttatagag    900

gaacttgaaa ccttgaaaga catttgttct cccaaaacag attactagaa atatttaact    960

atgaactgaa ggcagcatgt atagttgctt ttgaaggaat acaatatata gctggcaaga   1020

atggtggctt cttttctttg tatcattcat cttcttcttt aatcacttaa cattcctaaa   1080

atgcttcact gtacgtagtt aagtcgtagc tataacttca aattttttaa aagagacaaa   1140

ctgtaaaaaa tgtgtgtatt cttaaaatgc aatatttgta aggcttgttc caatgccaca   1200

tacttgcagc tcccattcta tgtgtcatca atagtgtcct atgcaataaa attatttgca   1260

ggtctttaaa tcattttagg aaaggatgat caaaaataat gcatccagca gtacaataaa   1320

agtaaaccac aaaaaaatac ctcaggaaag aatagaaaga aagtctatct aatgacatgc   1380

ctatatgaga agaatagcct agatatgaat atatggcatt tgcagatttt tatattagtt   1440

gctttgttaa aaaaaaaaag attgtattgc tgtccttgaa tgccatagtc aaagagagtt   1500

tttaatagaa ccatgttggt tgcactttgt agtgtttggt gctcatttaa atatctgaac   1560

atttactaca gtttttaact ctactgtgta atataaaaga tcttgcagaa gttcttagtg   1620

ttggtttaat attacctaat gaaagtgatg acatattttt tatatctgga atgagcctgt   1680

tgggatcgca ttgcatacct tcggggtaca agtcagtttc tacactgggt gctgatcctt   1740

gcacgcgccc tttctaccat ctcacggtgg ggatggccgc agggctgtgc acccagaaga   1800

agatggctgt tagcgtttcg gccttcataa tggcctgaga ctttctttct gtaggtggtc   1860

tggagctgtc cggctggtgg ccccctattt tgccatttag cgaacaacca caggaatttt   1920

aaaaacaaaa acatcccaag attttttcat ttcaaaatgc ttcaaagtcc acattagatc   1980

agatactccg ctgtcggcac attcagctga ggttcattac aatcgagact gcaatgtgat   2040

ctatgtttca tcttgttttt ataataaaaa gcttcaggga acaagcccaa agccctcacc   2100

acaaaaaa                                                            2108


<210>  678
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  678

Met Pro Thr Tyr Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly 
1               5                   10                  15


Val Val Met Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu 
            20                  25                  30


Ala Glu Glu Ala Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg 
        35                  40                  45


Glu Ala Ala Arg Glu Cys Arg Arg Lys Lys Lys Glu Tyr Val Lys Cys 
    50                  55                  60


Leu Glu Asn Arg Val Ala Val Leu Glu Asn Gln Asn Lys Thr Leu Ile 
65                  70                  75                  80


Glu Glu Leu Lys Ala Leu Lys Asp Leu Tyr Cys His Lys Val Glu 
                85                  90                  95


<210>  679
<211>  2144
<212>  DNA
<213>  Homo sapiens

<400>  679
gtaaaatgct gctgacagat ttagagttaa ctagctcacc actgcctctg cctccaagct     60

gccttttaga ctgaatagct tttcttgtta gccctacttt aacatttctt ttgaagtggt    120

tgtctgcttg aagagggaaa cacgtcatga aactgtaatg catgaacaga actcaggagt    180

tgtctggcca gcttagtggt aagatcgagc ctcctactga ggccgtccct gcatgcgcct    240

gatgaggaaa ctgaacttgc cccaagtcac atggctgctg ccactggtga catgccaact    300

taccagatcc gagctcctac tgctgctttg ccacagggag tggtgatggc tgcatcgccc    360

ggaagtttgc acagtcccca gcagctggca gaagaagcaa cacgcaaacg agagctgagg    420

ctaatgaaaa acagggaagc tgcccgggag tgtcgcagga agaagaaaga atatgtcaaa    480

tgtcttgaaa atcgtgtggc tgtgcttgaa aaccaaaaca agactctcat tgaggaactc    540

aaggccctca aagatcttta ttgccataaa gtagagtaac tgtctttgac ttggaccttg    600

tttactctaa tcaaggcagg agatgcagca gtcctactta ttgccatgtg gacttgtggg    660

aaggacacgt gtgaccctta agaatccagt ttggattagt gtttgaaatt gaattgggaa    720

tgttgttcca ggatgtggaa tgcagccgtg atcacactta ccgagcttac tttgatctgt    780

ttgtcaatag catgcaaaaa atgctttgtt tgccctttgc ttctgctttt tttcagggaa    840

gctgccaaag aatgtcgacg tcgaaagaaa gaatatgtaa aatgtctgga gagccgagtt    900

gcagtgctgg aagtccagaa caagaagctt atagaggaac ttgaaacctt gaaagacatt    960

tgttctccca aaacagatta ctagaaatat ttaactatga actgaaggca gcatgtatag   1020

ttgcttttga aggaatacaa tatatagctg gcaagaatgg tggcttcttt tctttgtatc   1080

attcatcttc ttctttaatc acttaacatt cctaaaatgc ttcactgtac gtagttaagt   1140

cgtagctata acttcaaatt ttttaaaaga gacaaactgt aaaaaatgtg tgtattctta   1200

aaatgcaata tttgtaaggc ttgttccaat gccacatact tgcagctccc attctatgtg   1260

tcatcaatag tgtcctatgc aataaaatta tttgcaggtc tttaaatcat tttaggaaag   1320

gatgatcaaa aataatgcat ccagcagtac aataaaagta aaccacaaaa aaatacctca   1380

ggaaagaata gaaagaaagt ctatctaatg acatgcctat atgagaagaa tagcctagat   1440

atgaatatat ggcatttgca gatttttata ttagttgctt tgttaaaaaa aaaaagattg   1500

tattgctgtc cttgaatgcc atagtcaaag agagttttta atagaaccat gttggttgca   1560

ctttgtagtg tttggtgctc atttaaatat ctgaacattt actacagttt ttaactctac   1620

tgtgtaatat aaaagatctt gcagaagttc ttagtgttgg tttaatatta cctaatgaaa   1680

gtgatgacat attttttata tctggaatga gcctgttggg atcgcattgc ataccttcgg   1740

ggtacaagtc agtttctaca ctgggtgctg atccttgcac gcgccctttc taccatctca   1800

cggtggggat ggccgcaggg ctgtgcaccc agaagaagat ggctgttagc gtttcggcct   1860

tcataatggc ctgagacttt ctttctgtag gtggtctgga gctgtccggc tggtggcccc   1920

ctattttgcc atttagcgaa caaccacagg aattttaaaa acaaaaacat cccaagattt   1980

tttcatttca aaatgcttca aagtccacat tagatcagat actccgctgt cggcacattc   2040

agctgaggtt cattacaatc gagactgcaa tgtgatctat gtttcatctt gtttttataa   2100

taaaaagctt cagggaacaa gcccaaagcc ctcaccacaa aaaa                    2144


<210>  680
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  680

Met Ala Ala Ala Thr Gly Asp Met Pro Thr Tyr Gln Ile Arg Ala Pro 
1               5                   10                  15


Thr Ala Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser Pro Gly Ser 
            20                  25                  30


Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala Thr Arg Lys Arg Glu 
        35                  40                  45


Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Arg Glu Cys Arg Arg Lys 
    50                  55                  60


Lys Lys Glu Tyr Val Lys Cys Leu Glu Asn Arg Val Ala Val Leu Glu 
65                  70                  75                  80


Asn Gln Asn Lys Thr Leu Ile Glu Glu Leu Lys Ala Leu Lys Asp Leu 
                85                  90                  95


Tyr Cys His Lys Val Glu 
            100


<210>  681
<211>  1663
<212>  DNA
<213>  Homo sapiens

<400>  681
gtaaaatgct gctgacagat ttagagttaa ctagctcacc actgcctctg cctccaagct     60

gccttttaga ctgaatagct tttcttgtta gccctacttt aacatttctt ttgaagtggt    120

tgtctgcttg aagagggaaa cacgtcatga aactgtaatg catgaacaga actcaggagt    180

tgtctggcca gcttagtgct gccactggtg acatgccaac ttaccagatc cgagctccta    240

ctgctgcttt gccacaggga gtggtgatgg ctgcatcgcc cggaagtttg cacagtcccc    300

agcagctggc agaagaagca acacgcaaac gagagctgag gctaatgaaa aacagggaag    360

ctgccaaaga atgtcgacgt cgaaagaaag aatatgtaaa atgtctggag agccgagttg    420

cagtgctgga agtccagaac aagaagctta tagaggaact tgaaaccttg aaagacattt    480

gttctcccaa aacagattac tagaaatatt taactatgaa ctgaaggcag catgtatagt    540

tgcttttgaa ggaatacaat atatagctgg caagaatggt ggcttctttt ctttgtatca    600

ttcatcttct tctttaatca cttaacattc ctaaaatgct tcactgtacg tagttaagtc    660

gtagctataa cttcaaattt tttaaaagag acaaactgta aaaaatgtgt gtattcttaa    720

aatgcaatat ttgtaaggct tgttccaatg ccacatactt gcagctccca ttctatgtgt    780

catcaatagt gtcctatgca ataaaattat ttgcaggtct ttaaatcatt ttaggaaagg    840

atgatcaaaa ataatgcatc cagcagtaca ataaaagtaa accacaaaaa aatacctcag    900

gaaagaatag aaagaaagtc tatctaatga catgcctata tgagaagaat agcctagata    960

tgaatatatg gcatttgcag atttttatat tagttgcttt gttaaaaaaa aaaagattgt   1020

attgctgtcc ttgaatgcca tagtcaaaga gagtttttaa tagaaccatg ttggttgcac   1080

tttgtagtgt ttggtgctca tttaaatatc tgaacattta ctacagtttt taactctact   1140

gtgtaatata aaagatcttg cagaagttct tagtgttggt ttaatattac ctaatgaaag   1200

tgatgacata ttttttatat ctggaatgag cctgttggga tcgcattgca taccttcggg   1260

gtacaagtca gtttctacac tgggtgctga tccttgcacg cgccctttct accatctcac   1320

ggtggggatg gccgcagggc tgtgcaccca gaagaagatg gctgttagcg tttcggcctt   1380

cataatggcc tgagactttc tttctgtagg tggtctggag ctgtccggct ggtggccccc   1440

tattttgcca tttagcgaac aaccacagga attttaaaaa caaaaacatc ccaagatttt   1500

ttcatttcaa aatgcttcaa agtccacatt agatcagata ctccgctgtc ggcacattca   1560

gctgaggttc attacaatcg agactgcaat gtgatctatg tttcatcttg tttttataat   1620

aaaaagcttc agggaacaag cccaaagccc tcaccacaaa aaa                     1663


<210>  682
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  682

Met Asn Arg Thr Gln Glu Leu Ser Gly Gln Leu Ser Ala Ala Thr Gly 
1               5                   10                  15


Asp Met Pro Thr Tyr Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln 
            20                  25                  30


Gly Val Val Met Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln 
        35                  40                  45


Leu Ala Glu Glu Ala Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn 
    50                  55                  60


Arg Glu Ala Ala Lys Glu Cys Arg Arg Arg Lys Lys Glu Tyr Val Lys 
65                  70                  75                  80


Cys Leu Glu Ser Arg Val Ala Val Leu Glu Val Gln Asn Lys Lys Leu 
                85                  90                  95


Ile Glu Glu Leu Glu Thr Leu Lys Asp Ile Cys Ser Pro Lys Thr Asp 
            100                 105                 110


Tyr 



<210>  683
<211>  1706
<212>  DNA
<213>  Homo sapiens

<400>  683
gtaaaatgct gctgacagat ttagagttaa ctagctcacc actgcctctg cctccaagct     60

gccttttaga ctgaatagct tttcttgtta gccctacttt aacatttctt ttgaagtggt    120

tgtctgcttg aagagggaaa cacgtcatga aactgtaatg catgaacaga actcaggagt    180

tgtctggcca gcttagtggt aagatcgagc ctcctactga ggccgtccct gcatgcgcct    240

gctgccactg gtgacatgcc aacttaccag atccgagctc ctactgctgc tttgccacag    300

ggagtggtga tggctgcatc gcccggaagt ttgcacagtc cccagcagct ggcagaagaa    360

gcaacacgca aacgagagct gaggctaatg aaaaacaggg aagctgccaa agaatgtcga    420

cgtcgaaaga aagaatatgt aaaatgtctg gagagccgag ttgcagtgct ggaagtccag    480

aacaagaagc ttatagagga acttgaaacc ttgaaagaca tttgttctcc caaaacagat    540

tactagaaat atttaactat gaactgaagg cagcatgtat agttgctttt gaaggaatac    600

aatatatagc tggcaagaat ggtggcttct tttctttgta tcattcatct tcttctttaa    660

tcacttaaca ttcctaaaat gcttcactgt acgtagttaa gtcgtagcta taacttcaaa    720

ttttttaaaa gagacaaact gtaaaaaatg tgtgtattct taaaatgcaa tatttgtaag    780

gcttgttcca atgccacata cttgcagctc ccattctatg tgtcatcaat agtgtcctat    840

gcaataaaat tatttgcagg tctttaaatc attttaggaa aggatgatca aaaataatgc    900

atccagcagt acaataaaag taaaccacaa aaaaatacct caggaaagaa tagaaagaaa    960

gtctatctaa tgacatgcct atatgagaag aatagcctag atatgaatat atggcatttg   1020

cagattttta tattagttgc tttgttaaaa aaaaaaagat tgtattgctg tccttgaatg   1080

ccatagtcaa agagagtttt taatagaacc atgttggttg cactttgtag tgtttggtgc   1140

tcatttaaat atctgaacat ttactacagt ttttaactct actgtgtaat ataaaagatc   1200

ttgcagaagt tcttagtgtt ggtttaatat tacctaatga aagtgatgac atatttttta   1260

tatctggaat gagcctgttg ggatcgcatt gcataccttc ggggtacaag tcagtttcta   1320

cactgggtgc tgatccttgc acgcgccctt tctaccatct cacggtgggg atggccgcag   1380

ggctgtgcac ccagaagaag atggctgtta gcgtttcggc cttcataatg gcctgagact   1440

ttctttctgt aggtggtctg gagctgtccg gctggtggcc ccctattttg ccatttagcg   1500

aacaaccaca ggaattttaa aaacaaaaac atcccaagat tttttcattt caaaatgctt   1560

caaagtccac attagatcag atactccgct gtcggcacat tcagctgagg ttcattacaa   1620

tcgagactgc aatgtgatct atgtttcatc ttgtttttat aataaaaagc ttcagggaac   1680

aagcccaaag ccctcaccac aaaaaa                                        1706


<210>  684
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  684

Met Pro Thr Tyr Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly 
1               5                   10                  15


Val Val Met Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu 
            20                  25                  30


Ala Glu Glu Ala Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg 
        35                  40                  45


Glu Ala Ala Lys Glu Cys Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys 
    50                  55                  60


Leu Glu Ser Arg Val Ala Val Leu Glu Val Gln Asn Lys Lys Leu Ile 
65                  70                  75                  80


Glu Glu Leu Glu Thr Leu Lys Asp Ile Cys Ser Pro Lys Thr Asp Tyr 
                85                  90                  95


<210>  685
<211>  2005
<212>  DNA
<213>  Homo sapiens

<400>  685
acattcttag ccaccgaagt atgggcacca aaagcgataa ggagcatgtg ttccttaata     60

aatgtcacat cagaaaatga ctgttccagg acagtaacca cctcccgatg gtagcagcaa    120

ttgcagagac agatgaatct gcagaatcag aaggtgtaat tgattctcat aaacgtagag    180

aaatcctttc acgaagaccc tcttatagga aaatactgaa tgaactgtcc tctgatgtgc    240

ctggtgttcc caagattgaa gaagagagat cagaggaaga aggaacacca cctagtattg    300

ctaccatggc agtaccaact agcatatatc agactagcac ggggcaatac attgctatag    360

cccaaggtgg aacaatccag atttctaacc caggatctga tggtgttcag ggactgcagg    420

cattaacaat gacaaattca ggagctcctc caccaggtgc tacaattgta cagtacgcag    480

cacaatcagc tgatggcaca cagcagttct ttgtcccagg cagccaggtt gttgttcaag    540

ctgccactgg tgacatgcca acttaccaga tccgagctcc tactgctgct ttgccacagg    600

gagtggtgat ggctgcatcg cccggaagtt tgcacagtcc ccagcagctg gcagaagaag    660

caacacgcaa acgagagctg aggctaatga aaaacaggga agctgccaaa gaatgtcgac    720

gtcgaaagaa agaatatgta aaatgtctgg agagccgagt tgcagtgctg gaagtccaga    780

acaagaagct tatagaggaa cttgaaacct tgaaagacat ttgttctccc aaaacagatt    840

actagaaata tttaactatg aactgaaggc agcatgtata gttgcttttg aaggaataca    900

atatatagct ggcaagaatg gtggcttctt ttctttgtat cattcatctt cttctttaat    960

cacttaacat tcctaaaatg cttcactgta cgtagttaag tcgtagctat aacttcaaat   1020

tttttaaaag agacaaactg taaaaaatgt gtgtattctt aaaatgcaat atttgtaagg   1080

cttgttccaa tgccacatac ttgcagctcc cattctatgt gtcatcaata gtgtcctatg   1140

caataaaatt atttgcaggt ctttaaatca ttttaggaaa ggatgatcaa aaataatgca   1200

tccagcagta caataaaagt aaaccacaaa aaaatacctc aggaaagaat agaaagaaag   1260

tctatctaat gacatgccta tatgagaaga atagcctaga tatgaatata tggcatttgc   1320

agatttttat attagttgct ttgttaaaaa aaaaaagatt gtattgctgt ccttgaatgc   1380

catagtcaaa gagagttttt aatagaacca tgttggttgc actttgtagt gtttggtgct   1440

catttaaata tctgaacatt tactacagtt tttaactcta ctgtgtaata taaaagatct   1500

tgcagaagtt cttagtgttg gtttaatatt acctaatgaa agtgatgaca tattttttat   1560

atctggaatg agcctgttgg gatcgcattg cataccttcg gggtacaagt cagtttctac   1620

actgggtgct gatccttgca cgcgcccttt ctaccatctc acggtgggga tggccgcagg   1680

gctgtgcacc cagaagaaga tggctgttag cgtttcggcc ttcataatgg cctgagactt   1740

tctttctgta ggtggtctgg agctgtccgg ctggtggccc cctattttgc catttagcga   1800

acaaccacag gaattttaaa aacaaaaaca tcccaagatt ttttcatttc aaaatgcttc   1860

aaagtccaca ttagatcaga tactccgctg tcggcacatt cagctgaggt tcattacaat   1920

cgagactgca atgtgatcta tgtttcatct tgtttttata ataaaaagct tcagggaaca   1980

agcccaaagc cctcaccaca aaaaa                                         2005


<210>  686
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  686

Met Val Ala Ala Ile Ala Glu Thr Asp Glu Ser Ala Glu Ser Glu Gly 
1               5                   10                  15


Val Ile Asp Ser His Lys Arg Arg Glu Ile Leu Ser Arg Arg Pro Ser 
            20                  25                  30


Tyr Arg Lys Ile Leu Asn Glu Leu Ser Ser Asp Val Pro Gly Val Pro 
        35                  40                  45


Lys Ile Glu Glu Glu Arg Ser Glu Glu Glu Gly Thr Pro Pro Ser Ile 
    50                  55                  60


Ala Thr Met Ala Val Pro Thr Ser Ile Tyr Gln Thr Ser Thr Gly Gln 
65                  70                  75                  80


Tyr Ile Ala Ile Ala Gln Gly Gly Thr Ile Gln Ile Ser Asn Pro Gly 
                85                  90                  95


Ser Asp Gly Val Gln Gly Leu Gln Ala Leu Thr Met Thr Asn Ser Gly 
            100                 105                 110


Ala Pro Pro Pro Gly Ala Thr Ile Val Gln Tyr Ala Ala Gln Ser Ala 
        115                 120                 125


Asp Gly Thr Gln Gln Phe Phe Val Pro Gly Ser Gln Val Val Val Gln 
    130                 135                 140


Ala Ala Thr Gly Asp Met Pro Thr Tyr Gln Ile Arg Ala Pro Thr Ala 
145                 150                 155                 160


Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser Pro Gly Ser Leu His 
                165                 170                 175


Ser Pro Gln Gln Leu Ala Glu Glu Ala Thr Arg Lys Arg Glu Leu Arg 
            180                 185                 190


Leu Met Lys Asn Arg Glu Ala Ala Lys Glu Cys Arg Arg Arg Lys Lys 
        195                 200                 205


Glu Tyr Val Lys Cys Leu Glu Ser Arg Val Ala Val Leu Glu Val Gln 
    210                 215                 220


Asn Lys Lys Leu Ile Glu Glu Leu Glu Thr Leu Lys Asp Ile Cys Ser 
225                 230                 235                 240


Pro Lys Thr Asp Tyr 
                245


<210>  687
<211>  1816
<212>  DNA
<213>  Homo sapiens

<400>  687
acattcttag ccaccgaagt atgggcacca aaagcgataa ggagcatgtg ttccttaata     60

aatgtcacat cagaaaatga ctgttccagg acagtaacca cctcccgatg gtagcagcaa    120

ttgcagagac agatgaatct gcagaatcag aaggtgtaat tgattctcat aaacgtagag    180

aaatcctttc acgaagaccc tcttatagga aaatactgaa tgaactgtcc tctgatgtgc    240

ctggtgttcc caagattgaa gaagagagat cagaggaaga aggaacacca cctagtattg    300

ctaccatggc agtaccaact agcatatatc agactagcac ggggcaatac actgccactg    360

gtgacatgcc aacttaccag atccgagctc ctactgctgc tttgccacag ggagtggtga    420

tggctgcatc gcccggaagt ttgcacagtc cccagcagct ggcagaagaa gcaacacgca    480

aacgagagct gaggctaatg aaaaacaggg aagctgccaa agaatgtcga cgtcgaaaga    540

aagaatatgt aaaatgtctg gagagccgag ttgcagtgct ggaagtccag aacaagaagc    600

ttatagagga acttgaaacc ttgaaagaca tttgttctcc caaaacagat tactagaaat    660

atttaactat gaactgaagg cagcatgtat agttgctttt gaaggaatac aatatatagc    720

tggcaagaat ggtggcttct tttctttgta tcattcatct tcttctttaa tcacttaaca    780

ttcctaaaat gcttcactgt acgtagttaa gtcgtagcta taacttcaaa ttttttaaaa    840

gagacaaact gtaaaaaatg tgtgtattct taaaatgcaa tatttgtaag gcttgttcca    900

atgccacata cttgcagctc ccattctatg tgtcatcaat agtgtcctat gcaataaaat    960

tatttgcagg tctttaaatc attttaggaa aggatgatca aaaataatgc atccagcagt   1020

acaataaaag taaaccacaa aaaaatacct caggaaagaa tagaaagaaa gtctatctaa   1080

tgacatgcct atatgagaag aatagcctag atatgaatat atggcatttg cagattttta   1140

tattagttgc tttgttaaaa aaaaaaagat tgtattgctg tccttgaatg ccatagtcaa   1200

agagagtttt taatagaacc atgttggttg cactttgtag tgtttggtgc tcatttaaat   1260

atctgaacat ttactacagt ttttaactct actgtgtaat ataaaagatc ttgcagaagt   1320

tcttagtgtt ggtttaatat tacctaatga aagtgatgac atatttttta tatctggaat   1380

gagcctgttg ggatcgcatt gcataccttc ggggtacaag tcagtttcta cactgggtgc   1440

tgatccttgc acgcgccctt tctaccatct cacggtgggg atggccgcag ggctgtgcac   1500

ccagaagaag atggctgtta gcgtttcggc cttcataatg gcctgagact ttctttctgt   1560

aggtggtctg gagctgtccg gctggtggcc ccctattttg ccatttagcg aacaaccaca   1620

ggaattttaa aaacaaaaac atcccaagat tttttcattt caaaatgctt caaagtccac   1680

attagatcag atactccgct gtcggcacat tcagctgagg ttcattacaa tcgagactgc   1740

aatgtgatct atgtttcatc ttgtttttat aataaaaagc ttcagggaac aagcccaaag   1800

ccctcaccac aaaaaa                                                   1816


<210>  688
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  688

Met Val Ala Ala Ile Ala Glu Thr Asp Glu Ser Ala Glu Ser Glu Gly 
1               5                   10                  15


Val Ile Asp Ser His Lys Arg Arg Glu Ile Leu Ser Arg Arg Pro Ser 
            20                  25                  30


Tyr Arg Lys Ile Leu Asn Glu Leu Ser Ser Asp Val Pro Gly Val Pro 
        35                  40                  45


Lys Ile Glu Glu Glu Arg Ser Glu Glu Glu Gly Thr Pro Pro Ser Ile 
    50                  55                  60


Ala Thr Met Ala Val Pro Thr Ser Ile Tyr Gln Thr Ser Thr Gly Gln 
65                  70                  75                  80


Tyr Thr Ala Thr Gly Asp Met Pro Thr Tyr Gln Ile Arg Ala Pro Thr 
                85                  90                  95


Ala Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser Pro Gly Ser Leu 
            100                 105                 110


His Ser Pro Gln Gln Leu Ala Glu Glu Ala Thr Arg Lys Arg Glu Leu 
        115                 120                 125


Arg Leu Met Lys Asn Arg Glu Ala Ala Lys Glu Cys Arg Arg Arg Lys 
    130                 135                 140


Lys Glu Tyr Val Lys Cys Leu Glu Ser Arg Val Ala Val Leu Glu Val 
145                 150                 155                 160


Gln Asn Lys Lys Leu Ile Glu Glu Leu Glu Thr Leu Lys Asp Ile Cys 
                165                 170                 175


Ser Pro Lys Thr Asp Tyr 
            180


<210>  689
<211>  2160
<212>  DNA
<213>  Homo sapiens

<400>  689
agctacgggt cagagctagt ccactaggtg ctaatcaaat gctgtgttac aacactgtga     60

ggttttccca gttataagtg tcactattag ggtttttttt aattgcaaag ccaaataagg    120

ctgtcaattg catcatctta ccttatttct tcagattaag tactgtttat agtgggattt    180

ttggtggatg tggtggcatc agcataatct atgtttcagg cgtcctatag aagaggatta    240

ttcttcaggg gatgtggaag aaaaggtagc agcaattgca gagacagatg aatctgcaga    300

atcagaaggt gtaattgatt ctcataaacg tagagaaatc ctttcacgaa gaccctctta    360

taggaaaata ctgaatgaac tgtcctctga tgtgcctggt gttcccaaga ttgaagaaga    420

gagatcagag gaagaaggaa caccacctag tattgctacc atggcagtac caactagcat    480

atatcagact agcacggggc aatacattgc tatagcccaa ggtggaacaa tccagatttc    540

taacccagga tctgatggtg ttcagggact gcaggcatta acaatgacaa attcaggagc    600

tcctccacca ggtgctacaa ttgtacagta cgcagcacaa tcagctgatg gcacacagca    660

gttctttgtc ccaggcagcc aggttgttgt tcaagctgcc actggtgaca tgccaactta    720

ccagatccga gctcctactg ctgctttgcc acagggagtg gtgatggctg catcgcccgg    780

aagtttgcac agtccccagc agctggcaga agaagcaaca cgcaaacgag agctgaggct    840

aatgaaaaac agggaagctg ccaaagaatg tcgacgtcga aagaaagaat atgtaaaatg    900

tctggagagc cgagttgcag tgctggaagt ccagaacaag aagcttatag aggaacttga    960

aaccttgaaa gacatttgtt ctcccaaaac agattactag aaatatttaa ctatgaactg   1020

aaggcagcat gtatagttgc ttttgaagga atacaatata tagctggcaa gaatggtggc   1080

ttcttttctt tgtatcattc atcttcttct ttaatcactt aacattccta aaatgcttca   1140

ctgtacgtag ttaagtcgta gctataactt caaatttttt aaaagagaca aactgtaaaa   1200

aatgtgtgta ttcttaaaat gcaatatttg taaggcttgt tccaatgcca catacttgca   1260

gctcccattc tatgtgtcat caatagtgtc ctatgcaata aaattatttg caggtcttta   1320

aatcatttta ggaaaggatg atcaaaaata atgcatccag cagtacaata aaagtaaacc   1380

acaaaaaaat acctcaggaa agaatagaaa gaaagtctat ctaatgacat gcctatatga   1440

gaagaatagc ctagatatga atatatggca tttgcagatt tttatattag ttgctttgtt   1500

aaaaaaaaaa agattgtatt gctgtccttg aatgccatag tcaaagagag tttttaatag   1560

aaccatgttg gttgcacttt gtagtgtttg gtgctcattt aaatatctga acatttacta   1620

cagtttttaa ctctactgtg taatataaaa gatcttgcag aagttcttag tgttggttta   1680

atattaccta atgaaagtga tgacatattt tttatatctg gaatgagcct gttgggatcg   1740

cattgcatac cttcggggta caagtcagtt tctacactgg gtgctgatcc ttgcacgcgc   1800

cctttctacc atctcacggt ggggatggcc gcagggctgt gcacccagaa gaagatggct   1860

gttagcgttt cggccttcat aatggcctga gactttcttt ctgtaggtgg tctggagctg   1920

tccggctggt ggccccctat tttgccattt agcgaacaac cacaggaatt ttaaaaacaa   1980

aaacatccca agattttttc atttcaaaat gcttcaaagt ccacattaga tcagatactc   2040

cgctgtcggc acattcagct gaggttcatt acaatcgaga ctgcaatgtg atctatgttt   2100

catcttgttt ttataataaa aagcttcagg gaacaagccc aaagccctca ccacaaaaaa   2160


<210>  690
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  690

Met Trp Trp His Gln His Asn Leu Cys Phe Arg Arg Pro Ile Glu Glu 
1               5                   10                  15


Asp Tyr Ser Ser Gly Asp Val Glu Glu Lys Val Ala Ala Ile Ala Glu 
            20                  25                  30


Thr Asp Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg 
        35                  40                  45


Arg Glu Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu 
    50                  55                  60


Leu Ser Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser 
65                  70                  75                  80


Glu Glu Glu Gly Thr Pro Pro Ser Ile Ala Thr Met Ala Val Pro Thr 
                85                  90                  95


Ser Ile Tyr Gln Thr Ser Thr Gly Gln Tyr Ile Ala Ile Ala Gln Gly 
            100                 105                 110


Gly Thr Ile Gln Ile Ser Asn Pro Gly Ser Asp Gly Val Gln Gly Leu 
        115                 120                 125


Gln Ala Leu Thr Met Thr Asn Ser Gly Ala Pro Pro Pro Gly Ala Thr 
    130                 135                 140


Ile Val Gln Tyr Ala Ala Gln Ser Ala Asp Gly Thr Gln Gln Phe Phe 
145                 150                 155                 160


Val Pro Gly Ser Gln Val Val Val Gln Ala Ala Thr Gly Asp Met Pro 
                165                 170                 175


Thr Tyr Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val 
            180                 185                 190


Met Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu 
        195                 200                 205


Glu Ala Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala 
    210                 215                 220


Ala Lys Glu Cys Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu 
225                 230                 235                 240


Ser Arg Val Ala Val Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu 
                245                 250                 255


Leu Glu Thr Leu Lys Asp Ile Cys Ser Pro Lys Thr Asp Tyr 
            260                 265                 270


<210>  691
<211>  1971
<212>  DNA
<213>  Homo sapiens

<400>  691
agctacgggt cagagctagt ccactaggtg ctaatcaaat gctgtgttac aacactgtga     60

ggttttccca gttataagtg tcactattag ggtttttttt aattgcaaag ccaaataagg    120

ctgtcaattg catcatctta ccttatttct tcagattaag tactgtttat agtgggattt    180

ttggtggatg tggtggcatc agcataatct atgtttcagg cgtcctatag aagaggatta    240

ttcttcaggg gatgtggaag aaaaggtagc agcaattgca gagacagatg aatctgcaga    300

atcagaaggt gtaattgatt ctcataaacg tagagaaatc ctttcacgaa gaccctctta    360

taggaaaata ctgaatgaac tgtcctctga tgtgcctggt gttcccaaga ttgaagaaga    420

gagatcagag gaagaaggaa caccacctag tattgctacc atggcagtac caactagcat    480

atatcagact agcacggggc aatacactgc cactggtgac atgccaactt accagatccg    540

agctcctact gctgctttgc cacagggagt ggtgatggct gcatcgcccg gaagtttgca    600

cagtccccag cagctggcag aagaagcaac acgcaaacga gagctgaggc taatgaaaaa    660

cagggaagct gccaaagaat gtcgacgtcg aaagaaagaa tatgtaaaat gtctggagag    720

ccgagttgca gtgctggaag tccagaacaa gaagcttata gaggaacttg aaaccttgaa    780

agacatttgt tctcccaaaa cagattacta gaaatattta actatgaact gaaggcagca    840

tgtatagttg cttttgaagg aatacaatat atagctggca agaatggtgg cttcttttct    900

ttgtatcatt catcttcttc tttaatcact taacattcct aaaatgcttc actgtacgta    960

gttaagtcgt agctataact tcaaattttt taaaagagac aaactgtaaa aaatgtgtgt   1020

attcttaaaa tgcaatattt gtaaggcttg ttccaatgcc acatacttgc agctcccatt   1080

ctatgtgtca tcaatagtgt cctatgcaat aaaattattt gcaggtcttt aaatcatttt   1140

aggaaaggat gatcaaaaat aatgcatcca gcagtacaat aaaagtaaac cacaaaaaaa   1200

tacctcagga aagaatagaa agaaagtcta tctaatgaca tgcctatatg agaagaatag   1260

cctagatatg aatatatggc atttgcagat ttttatatta gttgctttgt taaaaaaaaa   1320

aagattgtat tgctgtcctt gaatgccata gtcaaagaga gtttttaata gaaccatgtt   1380

ggttgcactt tgtagtgttt ggtgctcatt taaatatctg aacatttact acagttttta   1440

actctactgt gtaatataaa agatcttgca gaagttctta gtgttggttt aatattacct   1500

aatgaaagtg atgacatatt ttttatatct ggaatgagcc tgttgggatc gcattgcata   1560

ccttcggggt acaagtcagt ttctacactg ggtgctgatc cttgcacgcg ccctttctac   1620

catctcacgg tggggatggc cgcagggctg tgcacccaga agaagatggc tgttagcgtt   1680

tcggccttca taatggcctg agactttctt tctgtaggtg gtctggagct gtccggctgg   1740

tggcccccta ttttgccatt tagcgaacaa ccacaggaat tttaaaaaca aaaacatccc   1800

aagatttttt catttcaaaa tgcttcaaag tccacattag atcagatact ccgctgtcgg   1860

cacattcagc tgaggttcat tacaatcgag actgcaatgt gatctatgtt tcatcttgtt   1920

tttataataa aaagcttcag ggaacaagcc caaagccctc accacaaaaa a            1971


<210>  692
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  692

Met Trp Trp His Gln His Asn Leu Cys Phe Arg Arg Pro Ile Glu Glu 
1               5                   10                  15


Asp Tyr Ser Ser Gly Asp Val Glu Glu Lys Val Ala Ala Ile Ala Glu 
            20                  25                  30


Thr Asp Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg 
        35                  40                  45


Arg Glu Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu 
    50                  55                  60


Leu Ser Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser 
65                  70                  75                  80


Glu Glu Glu Gly Thr Pro Pro Ser Ile Ala Thr Met Ala Val Pro Thr 
                85                  90                  95


Ser Ile Tyr Gln Thr Ser Thr Gly Gln Tyr Thr Ala Thr Gly Asp Met 
            100                 105                 110


Pro Thr Tyr Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly Val 
        115                 120                 125


Val Met Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala 
    130                 135                 140


Glu Glu Ala Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu 
145                 150                 155                 160


Ala Ala Lys Glu Cys Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu 
                165                 170                 175


Glu Ser Arg Val Ala Val Leu Glu Val Gln Asn Lys Lys Leu Ile Glu 
            180                 185                 190


Glu Leu Glu Thr Leu Lys Asp Ile Cys Ser Pro Lys Thr Asp Tyr 
        195                 200                 205


<210>  693
<211>  1786
<212>  DNA
<213>  Homo sapiens

<400>  693
gctggcggcc ggcagggggc ggagttcgag cctggatttt tttcctcggg gcctcccccg     60

ggaggccgtc ccggcgtggg ggaggggagg acggggcggg aggacgcggt tcggtcggct    120

gcagcgctac ttttggtccg gggtcggcag ggaggccgcg gctaccgcat cacagctgac    180

gtgaggacta cgtggggccg ctgccggctc cgggttgctg ggcggcggcg ccgctgctga    240

gcggcggtcg ggctcgccgt ctccacctcc tcgcgtccgt aatcagtgac gaggtccgct    300

acgtaaatcc ctttgcggcg gctgccactg gtgacatgcc aacttaccag atccgagctc    360

ctactgctgc tttgccacag ggagtggtga tggctgcatc gcccggaagt ttgcacagtc    420

cccagcagct ggcagaagaa gcaacacgca aacgagagct gaggctaatg aaaaacaggg    480

aagctgccaa agaatgtcga cgtcgaaaga aagaatatgt aaaatgtctg gagagccgag    540

ttgcagtgct ggaagtccag aacaagaagc ttatagagga acttgaaacc ttgaaagaca    600

tttgttctcc caaaacagat tactagaaat atttaactat gaactgaagg cagcatgtat    660

agttgctttt gaaggaatac aatatatagc tggcaagaat ggtggcttct tttctttgta    720

tcattcatct tcttctttaa tcacttaaca ttcctaaaat gcttcactgt acgtagttaa    780

gtcgtagcta taacttcaaa ttttttaaaa gagacaaact gtaaaaaatg tgtgtattct    840

taaaatgcaa tatttgtaag gcttgttcca atgccacata cttgcagctc ccattctatg    900

tgtcatcaat agtgtcctat gcaataaaat tatttgcagg tctttaaatc attttaggaa    960

aggatgatca aaaataatgc atccagcagt acaataaaag taaaccacaa aaaaatacct   1020

caggaaagaa tagaaagaaa gtctatctaa tgacatgcct atatgagaag aatagcctag   1080

atatgaatat atggcatttg cagattttta tattagttgc tttgttaaaa aaaaaaagat   1140

tgtattgctg tccttgaatg ccatagtcaa agagagtttt taatagaacc atgttggttg   1200

cactttgtag tgtttggtgc tcatttaaat atctgaacat ttactacagt ttttaactct   1260

actgtgtaat ataaaagatc ttgcagaagt tcttagtgtt ggtttaatat tacctaatga   1320

aagtgatgac atatttttta tatctggaat gagcctgttg ggatcgcatt gcataccttc   1380

ggggtacaag tcagtttcta cactgggtgc tgatccttgc acgcgccctt tctaccatct   1440

cacggtgggg atggccgcag ggctgtgcac ccagaagaag atggctgtta gcgtttcggc   1500

cttcataatg gcctgagact ttctttctgt aggtggtctg gagctgtccg gctggtggcc   1560

ccctattttg ccatttagcg aacaaccaca ggaattttaa aaacaaaaac atcccaagat   1620

tttttcattt caaaatgctt caaagtccac attagatcag atactccgct gtcggcacat   1680

tcagctgagg ttcattacaa tcgagactgc aatgtgatct atgtttcatc ttgtttttat   1740

aataaaaagc ttcagggaac aagcccaaag ccctcaccac aaaaaa                  1786


<210>  694
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  694

Met Pro Thr Tyr Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly 
1               5                   10                  15


Val Val Met Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu 
            20                  25                  30


Ala Glu Glu Ala Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg 
        35                  40                  45


Glu Ala Ala Lys Glu Cys Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys 
    50                  55                  60


Leu Glu Ser Arg Val Ala Val Leu Glu Val Gln Asn Lys Lys Leu Ile 
65                  70                  75                  80


Glu Glu Leu Glu Thr Leu Lys Asp Ile Cys Ser Pro Lys Thr Asp Tyr 
                85                  90                  95


<210>  695
<211>  2188
<212>  DNA
<213>  Homo sapiens

<400>  695
gctggcggcc ggcagggggc ggagttcgag cctggatttt tttcctcggg gcctcccccg     60

ggaggccgtc ccggcgtggg ggaggggagg acggggcggg aggacgcggt tcggtcggct    120

gcagcgctac ttttggtccg gggtcggcag ggaggccgcg gctaccgcat cacagctgac    180

gtgaggacta cgtggggccg ctgccggctc cgggttgctg ggcggcggcg ccgctgctga    240

gcggcggtcg ggctcgccgt ctccacctcc tcgcgtccgt aatcagtgac gaggtccgct    300

acgtaaatcc ctttgcggcg gctgccactg gtgacatgcc aacttaccag atccgagctc    360

ctactgctgc tttgccacag ggagtggtga tggctgcatc gcccggaagt ttgcacagtc    420

cccagcagct ggcagaagaa gcaacacgca aacgagagct gaggctaatg aaaaacaggg    480

aagctgcccg ggagtgtcgc aggaagaaga aagaatatgt caaatgtctt gaaaatcgtg    540

tggctgtgct tgaaaaccaa aacaagactc tcattgagga actcaaggcc ctcaaagatc    600

tttattgcca taaagtagag taactgtctt tgacttggac cttgtttact ctaatcaagg    660

caggagatgc agcagtccta cttattgcca tgtggacttg tgggaaggac acgtgtgacc    720

cttaagaatc cagtttggat tagtgtttga aattgaattg ggaatgttgt tccaggatgt    780

ggaatgcagc cgtgatcaca cttaccgagc ttactttgat ctgtttgtca atagcatgca    840

aaaaatgctt tgtttgccct ttgcttctgc tttttttcag ggaagctgcc aaagaatgtc    900

gacgtcgaaa gaaagaatat gtaaaatgtc tggagagccg agttgcagtg ctggaagtcc    960

agaacaagaa gcttatagag gaacttgaaa ccttgaaaga catttgttct cccaaaacag   1020

attactagaa atatttaact atgaactgaa ggcagcatgt atagttgctt ttgaaggaat   1080

acaatatata gctggcaaga atggtggctt cttttctttg tatcattcat cttcttcttt   1140

aatcacttaa cattcctaaa atgcttcact gtacgtagtt aagtcgtagc tataacttca   1200

aattttttaa aagagacaaa ctgtaaaaaa tgtgtgtatt cttaaaatgc aatatttgta   1260

aggcttgttc caatgccaca tacttgcagc tcccattcta tgtgtcatca atagtgtcct   1320

atgcaataaa attatttgca ggtctttaaa tcattttagg aaaggatgat caaaaataat   1380

gcatccagca gtacaataaa agtaaaccac aaaaaaatac ctcaggaaag aatagaaaga   1440

aagtctatct aatgacatgc ctatatgaga agaatagcct agatatgaat atatggcatt   1500

tgcagatttt tatattagtt gctttgttaa aaaaaaaaag attgtattgc tgtccttgaa   1560

tgccatagtc aaagagagtt tttaatagaa ccatgttggt tgcactttgt agtgtttggt   1620

gctcatttaa atatctgaac atttactaca gtttttaact ctactgtgta atataaaaga   1680

tcttgcagaa gttcttagtg ttggtttaat attacctaat gaaagtgatg acatattttt   1740

tatatctgga atgagcctgt tgggatcgca ttgcatacct tcggggtaca agtcagtttc   1800

tacactgggt gctgatcctt gcacgcgccc tttctaccat ctcacggtgg ggatggccgc   1860

agggctgtgc acccagaaga agatggctgt tagcgtttcg gccttcataa tggcctgaga   1920

ctttctttct gtaggtggtc tggagctgtc cggctggtgg ccccctattt tgccatttag   1980

cgaacaacca caggaatttt aaaaacaaaa acatcccaag attttttcat ttcaaaatgc   2040

ttcaaagtcc acattagatc agatactccg ctgtcggcac attcagctga ggttcattac   2100

aatcgagact gcaatgtgat ctatgtttca tcttgttttt ataataaaaa gcttcaggga   2160

acaagcccaa agccctcacc acaaaaaa                                      2188


<210>  696
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  696

Met Pro Thr Tyr Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly 
1               5                   10                  15


Val Val Met Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu 
            20                  25                  30


Ala Glu Glu Ala Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg 
        35                  40                  45


Glu Ala Ala Arg Glu Cys Arg Arg Lys Lys Lys Glu Tyr Val Lys Cys 
    50                  55                  60


Leu Glu Asn Arg Val Ala Val Leu Glu Asn Gln Asn Lys Thr Leu Ile 
65                  70                  75                  80


Glu Glu Leu Lys Ala Leu Lys Asp Leu Tyr Cys His Lys Val Glu 
                85                  90                  95


<210>  697
<211>  2519
<212>  DNA
<213>  Homo sapiens

<400>  697
gataaataaa gaaaacagga aaggaggaaa gcattgatta caaatatctt aacaatgagc     60

aaatgtgcaa ggaaaaaata tattaagaca aatccaagac aaatgaccat ggaaacagtt    120

gaatcccagc atgatggaag tataacagct tctttgacag agagcaagtc tgctcatgtg    180

cagactcaga ctggccaaaa ttcaatccct gctttagctc aggtagcagc aattgcagag    240

acagatgaat ctgcagaatc agaaggtgta attgattctc ataaacgtag agaaatcctt    300

tcacgaagac cctcttatag gaaaatactg aatgaactgt cctctgatgt gcctggtgtt    360

cccaagattg aagaagagag atcagaggaa gaaggaacac cacctagtat tgctaccatg    420

gcagtaccaa ctagcatata tcagactagc acggggcaat acattgctat agcccaaggt    480

ggaacaatcc agatttctaa cccaggatct gatggtgttc agggactgca ggcattaaca    540

atgacaaatt caggagctcc tccaccaggt gctacaattg tacagtacgc agcacaatca    600

gctgatggca cacagcagtt ctttgtccca ggcagccagg ttgttgttca agctgccact    660

ggtgacatgc caacttacca gatccgagct cctactgctg ctttgccaca gggagtggtg    720

atggctgcat cgcccggaag tttgcacagt ccccagcagc tggcagaaga agcaacacgc    780

aaacgagagc tgaggctaat gaaaaacagg gaagctgccc gggagtgtcg caggaagaag    840

aaagaatatg tcaaatgtct tgaaaatcgt gtggctgtgc ttgaaaacca aaacaagact    900

ctcattgagg aactcaaggc cctcaaagat ctttattgcc ataaagtaga gtaactgtct    960

ttgacttgga ccttgtttac tctaatcaag gcaggagatg cagcagtcct acttattgcc   1020

atgtggactt gtgggaagga cacgtgtgac ccttaagaat ccagtttgga ttagtgtttg   1080

aaattgaatt gggaatgttg ttccaggatg tggaatgcag ccgtgatcac acttaccgag   1140

cttactttga tctgtttgtc aatagcatgc aaaaaatgct ttgtttgccc tttgcttctg   1200

ctttttttca gggaagctgc caaagaatgt cgacgtcgaa agaaagaata tgtaaaatgt   1260

ctggagagcc gagttgcagt gctggaagtc cagaacaaga agcttataga ggaacttgaa   1320

accttgaaag acatttgttc tcccaaaaca gattactaga aatatttaac tatgaactga   1380

aggcagcatg tatagttgct tttgaaggaa tacaatatat agctggcaag aatggtggct   1440

tcttttcttt gtatcattca tcttcttctt taatcactta acattcctaa aatgcttcac   1500

tgtacgtagt taagtcgtag ctataacttc aaatttttta aaagagacaa actgtaaaaa   1560

atgtgtgtat tcttaaaatg caatatttgt aaggcttgtt ccaatgccac atacttgcag   1620

ctcccattct atgtgtcatc aatagtgtcc tatgcaataa aattatttgc aggtctttaa   1680

atcattttag gaaaggatga tcaaaaataa tgcatccagc agtacaataa aagtaaacca   1740

caaaaaaata cctcaggaaa gaatagaaag aaagtctatc taatgacatg cctatatgag   1800

aagaatagcc tagatatgaa tatatggcat ttgcagattt ttatattagt tgctttgtta   1860

aaaaaaaaaa gattgtattg ctgtccttga atgccatagt caaagagagt ttttaataga   1920

accatgttgg ttgcactttg tagtgtttgg tgctcattta aatatctgaa catttactac   1980

agtttttaac tctactgtgt aatataaaag atcttgcaga agttcttagt gttggtttaa   2040

tattacctaa tgaaagtgat gacatatttt ttatatctgg aatgagcctg ttgggatcgc   2100

attgcatacc ttcggggtac aagtcagttt ctacactggg tgctgatcct tgcacgcgcc   2160

ctttctacca tctcacggtg gggatggccg cagggctgtg cacccagaag aagatggctg   2220

ttagcgtttc ggccttcata atggcctgag actttctttc tgtaggtggt ctggagctgt   2280

ccggctggtg gccccctatt ttgccattta gcgaacaacc acaggaattt taaaaacaaa   2340

aacatcccaa gattttttca tttcaaaatg cttcaaagtc cacattagat cagatactcc   2400

gctgtcggca cattcagctg aggttcatta caatcgagac tgcaatgtga tctatgtttc   2460

atcttgtttt tataataaaa agcttcaggg aacaagccca aagccctcac cacaaaaaa    2519


<210>  698
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  698

Met Ser Lys Cys Ala Arg Lys Lys Tyr Ile Lys Thr Asn Pro Arg Gln 
1               5                   10                  15


Met Thr Met Glu Thr Val Glu Ser Gln His Asp Gly Ser Ile Thr Ala 
            20                  25                  30


Ser Leu Thr Glu Ser Lys Ser Ala His Val Gln Thr Gln Thr Gly Gln 
        35                  40                  45


Asn Ser Ile Pro Ala Leu Ala Gln Val Ala Ala Ile Ala Glu Thr Asp 
    50                  55                  60


Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg Glu 
65                  70                  75                  80


Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu Ser 
                85                  90                  95


Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu Glu 
            100                 105                 110


Glu Gly Thr Pro Pro Ser Ile Ala Thr Met Ala Val Pro Thr Ser Ile 
        115                 120                 125


Tyr Gln Thr Ser Thr Gly Gln Tyr Ile Ala Ile Ala Gln Gly Gly Thr 
    130                 135                 140


Ile Gln Ile Ser Asn Pro Gly Ser Asp Gly Val Gln Gly Leu Gln Ala 
145                 150                 155                 160


Leu Thr Met Thr Asn Ser Gly Ala Pro Pro Pro Gly Ala Thr Ile Val 
                165                 170                 175


Gln Tyr Ala Ala Gln Ser Ala Asp Gly Thr Gln Gln Phe Phe Val Pro 
            180                 185                 190


Gly Ser Gln Val Val Val Gln Ala Ala Thr Gly Asp Met Pro Thr Tyr 
        195                 200                 205


Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met Ala 
    210                 215                 220


Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala 
225                 230                 235                 240


Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Arg 
                245                 250                 255


Glu Cys Arg Arg Lys Lys Lys Glu Tyr Val Lys Cys Leu Glu Asn Arg 
            260                 265                 270


Val Ala Val Leu Glu Asn Gln Asn Lys Thr Leu Ile Glu Glu Leu Lys 
        275                 280                 285


Ala Leu Lys Asp Leu Tyr Cys His Lys Val Glu 
    290                 295


<210>  699
<211>  2330
<212>  DNA
<213>  Homo sapiens

<400>  699
gataaataaa gaaaacagga aaggaggaaa gcattgatta caaatatctt aacaatgagc     60

aaatgtgcaa ggaaaaaata tattaagaca aatccaagac aaatgaccat ggaaacagtt    120

gaatcccagc atgatggaag tataacagct tctttgacag agagcaagtc tgctcatgtg    180

cagactcaga ctggccaaaa ttcaatccct gctttagctc aggtagcagc aattgcagag    240

acagatgaat ctgcagaatc agaaggtgta attgattctc ataaacgtag agaaatcctt    300

tcacgaagac cctcttatag gaaaatactg aatgaactgt cctctgatgt gcctggtgtt    360

cccaagattg aagaagagag atcagaggaa gaaggaacac cacctagtat tgctaccatg    420

gcagtaccaa ctagcatata tcagactagc acggggcaat acactgccac tggtgacatg    480

ccaacttacc agatccgagc tcctactgct gctttgccac agggagtggt gatggctgca    540

tcgcccggaa gtttgcacag tccccagcag ctggcagaag aagcaacacg caaacgagag    600

ctgaggctaa tgaaaaacag ggaagctgcc cgggagtgtc gcaggaagaa gaaagaatat    660

gtcaaatgtc ttgaaaatcg tgtggctgtg cttgaaaacc aaaacaagac tctcattgag    720

gaactcaagg ccctcaaaga tctttattgc cataaagtag agtaactgtc tttgacttgg    780

accttgttta ctctaatcaa ggcaggagat gcagcagtcc tacttattgc catgtggact    840

tgtgggaagg acacgtgtga cccttaagaa tccagtttgg attagtgttt gaaattgaat    900

tgggaatgtt gttccaggat gtggaatgca gccgtgatca cacttaccga gcttactttg    960

atctgtttgt caatagcatg caaaaaatgc tttgtttgcc ctttgcttct gctttttttc   1020

agggaagctg ccaaagaatg tcgacgtcga aagaaagaat atgtaaaatg tctggagagc   1080

cgagttgcag tgctggaagt ccagaacaag aagcttatag aggaacttga aaccttgaaa   1140

gacatttgtt ctcccaaaac agattactag aaatatttaa ctatgaactg aaggcagcat   1200

gtatagttgc ttttgaagga atacaatata tagctggcaa gaatggtggc ttcttttctt   1260

tgtatcattc atcttcttct ttaatcactt aacattccta aaatgcttca ctgtacgtag   1320

ttaagtcgta gctataactt caaatttttt aaaagagaca aactgtaaaa aatgtgtgta   1380

ttcttaaaat gcaatatttg taaggcttgt tccaatgcca catacttgca gctcccattc   1440

tatgtgtcat caatagtgtc ctatgcaata aaattatttg caggtcttta aatcatttta   1500

ggaaaggatg atcaaaaata atgcatccag cagtacaata aaagtaaacc acaaaaaaat   1560

acctcaggaa agaatagaaa gaaagtctat ctaatgacat gcctatatga gaagaatagc   1620

ctagatatga atatatggca tttgcagatt tttatattag ttgctttgtt aaaaaaaaaa   1680

agattgtatt gctgtccttg aatgccatag tcaaagagag tttttaatag aaccatgttg   1740

gttgcacttt gtagtgtttg gtgctcattt aaatatctga acatttacta cagtttttaa   1800

ctctactgtg taatataaaa gatcttgcag aagttcttag tgttggttta atattaccta   1860

atgaaagtga tgacatattt tttatatctg gaatgagcct gttgggatcg cattgcatac   1920

cttcggggta caagtcagtt tctacactgg gtgctgatcc ttgcacgcgc cctttctacc   1980

atctcacggt ggggatggcc gcagggctgt gcacccagaa gaagatggct gttagcgttt   2040

cggccttcat aatggcctga gactttcttt ctgtaggtgg tctggagctg tccggctggt   2100

ggccccctat tttgccattt agcgaacaac cacaggaatt ttaaaaacaa aaacatccca   2160

agattttttc atttcaaaat gcttcaaagt ccacattaga tcagatactc cgctgtcggc   2220

acattcagct gaggttcatt acaatcgaga ctgcaatgtg atctatgttt catcttgttt   2280

ttataataaa aagcttcagg gaacaagccc aaagccctca ccacaaaaaa              2330


<210>  700
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  700

Met Ser Lys Cys Ala Arg Lys Lys Tyr Ile Lys Thr Asn Pro Arg Gln 
1               5                   10                  15


Met Thr Met Glu Thr Val Glu Ser Gln His Asp Gly Ser Ile Thr Ala 
            20                  25                  30


Ser Leu Thr Glu Ser Lys Ser Ala His Val Gln Thr Gln Thr Gly Gln 
        35                  40                  45


Asn Ser Ile Pro Ala Leu Ala Gln Val Ala Ala Ile Ala Glu Thr Asp 
    50                  55                  60


Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg Glu 
65                  70                  75                  80


Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu Ser 
                85                  90                  95


Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu Glu 
            100                 105                 110


Glu Gly Thr Pro Pro Ser Ile Ala Thr Met Ala Val Pro Thr Ser Ile 
        115                 120                 125


Tyr Gln Thr Ser Thr Gly Gln Tyr Thr Ala Thr Gly Asp Met Pro Thr 
    130                 135                 140


Tyr Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met 
145                 150                 155                 160


Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu 
                165                 170                 175


Ala Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala 
            180                 185                 190


Arg Glu Cys Arg Arg Lys Lys Lys Glu Tyr Val Lys Cys Leu Glu Asn 
        195                 200                 205


Arg Val Ala Val Leu Glu Asn Gln Asn Lys Thr Leu Ile Glu Glu Leu 
    210                 215                 220


Lys Ala Leu Lys Asp Leu Tyr Cys His Lys Val Glu 
225                 230                 235


<210>  701
<211>  2687
<212>  DNA
<213>  Homo sapiens

<400>  701
gctggcggcc ggcagggggc ggagttcgag cctggatttt tttcctcggg gcctcccccg     60

ggaggccgtc ccggcgtggg ggaggggagg acggggcggg aggacgcggt tcggtcggct    120

gcagcgctac ttttggtccg gggtcggcag ggaggccgcg gctaccgcat cacagctgac    180

gtgaggacta cgtggggccg ctgccggctc cgggttgctg ggcggcggcg ccgctgctga    240

gcggcggtcg ggctcgccgt ctccacctcc tcgcgtccgt aatcagtgac gaggtccgct    300

acgtaaatcc ctttgcggcg ggataaataa agaaaacagg aaaggaggaa agcattgatt    360

acaaatatct taacaatgag caaatgtgca aggaaaaaat atattaagac aaatccaaga    420

caaatgacca tggaaacagt tgaatcccag catgatggaa gtataacagc ttctttgaca    480

gagagcaagt ctgctcatgt gcagactcag actggccaaa attcaatccc tgctttagct    540

caggtagcag caattgcaga gacagatgaa tctgcagaat cagaaggtgt aattgattct    600

cataaacgta gagaaatcct ttcacgaaga ccctcttata ggaaaatact gaatgaactg    660

tcctctgatg tgcctggtgt tcccaagatt gaagaagaga gatcagagga agaaggaaca    720

ccacctagta ttgctaccat ggcagtacca actagcatat atcagactag cacggggcaa    780

tacaatgagg aaactgaact tgccccaagt cacatggctg ctgccactgg tgacatgcca    840

acttaccaga tccgagctcc tactgctgct ttgccacagg gagtggtgat ggctgcatcg    900

cccggaagtt tgcacagtcc ccagcagctg gcagaagaag caacacgcaa acgagagctg    960

aggctaatga aaaacaggga agctgcccgg gagtgtcgca ggaagaagaa agaatatgtc   1020

aaatgtcttg aaaatcgtgt ggctgtgctt gaaaaccaaa acaagactct cattgaggaa   1080

ctcaaggccc tcaaagatct ttattgccat aaagtagagt aactgtcttt gacttggacc   1140

ttgtttactc taatcaaggc aggagatgca gcagtcctac ttattgccat gtggacttgt   1200

gggaaggaca cgtgtgaccc ttaagaatcc agtttggatt agtgtttgaa attgaattgg   1260

gaatgttgtt ccaggatgtg gaatgcagcc gtgatcacac ttaccgagct tactttgatc   1320

tgtttgtcaa tagcatgcaa aaaatgcttt gtttgccctt tgcttctgct ttttttcagg   1380

gaagctgcca aagaatgtcg acgtcgaaag aaagaatatg taaaatgtct ggagagccga   1440

gttgcagtgc tggaagtcca gaacaagaag cttatagagg aacttgaaac cttgaaagac   1500

atttgttctc ccaaaacaga ttactagaaa tatttaacta tgaactgaag gcagcatgta   1560

tagttgcttt tgaaggaata caatatatag ctggcaagaa tggtggcttc ttttctttgt   1620

atcattcatc ttcttcttta atcacttaac attcctaaaa tgcttcactg tacgtagtta   1680

agtcgtagct ataacttcaa attttttaaa agagacaaac tgtaaaaaat gtgtgtattc   1740

ttaaaatgca atatttgtaa ggcttgttcc aatgccacat acttgcagct cccattctat   1800

gtgtcatcaa tagtgtccta tgcaataaaa ttatttgcag gtctttaaat cattttagga   1860

aaggatgatc aaaaataatg catccagcag tacaataaaa gtaaaccaca aaaaaatacc   1920

tcaggaaaga atagaaagaa agtctatcta atgacatgcc tatatgagaa gaatagccta   1980

gatatgaata tatggcattt gcagattttt atattagttg ctttgttaaa aaaaaaaaga   2040

ttgtattgct gtccttgaat gccatagtca aagagagttt ttaatagaac catgttggtt   2100

gcactttgta gtgtttggtg ctcatttaaa tatctgaaca tttactacag tttttaactc   2160

tactgtgtaa tataaaagat cttgcagaag ttcttagtgt tggtttaata ttacctaatg   2220

aaagtgatga catatttttt atatctggaa tgagcctgtt gggatcgcat tgcatacctt   2280

cggggtacaa gtcagtttct acactgggtg ctgatccttg cacgcgccct ttctaccatc   2340

tcacggtggg gatggccgca gggctgtgca cccagaagaa gatggctgtt agcgtttcgg   2400

ccttcataat ggcctgagac tttctttctg taggtggtct ggagctgtcc ggctggtggc   2460

cccctatttt gccatttagc gaacaaccac aggaatttta aaaacaaaaa catcccaaga   2520

ttttttcatt tcaaaatgct tcaaagtcca cattagatca gatactccgc tgtcggcaca   2580

ttcagctgag gttcattaca atcgagactg caatgtgatc tatgtttcat cttgttttta   2640

taataaaaag cttcagggaa caagcccaaa gccctcacca caaaaaa                 2687


<210>  702
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  702

Met Ser Lys Cys Ala Arg Lys Lys Tyr Ile Lys Thr Asn Pro Arg Gln 
1               5                   10                  15


Met Thr Met Glu Thr Val Glu Ser Gln His Asp Gly Ser Ile Thr Ala 
            20                  25                  30


Ser Leu Thr Glu Ser Lys Ser Ala His Val Gln Thr Gln Thr Gly Gln 
        35                  40                  45


Asn Ser Ile Pro Ala Leu Ala Gln Val Ala Ala Ile Ala Glu Thr Asp 
    50                  55                  60


Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg Glu 
65                  70                  75                  80


Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu Ser 
                85                  90                  95


Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu Glu 
            100                 105                 110


Glu Gly Thr Pro Pro Ser Ile Ala Thr Met Ala Val Pro Thr Ser Ile 
        115                 120                 125


Tyr Gln Thr Ser Thr Gly Gln Tyr Asn Glu Glu Thr Glu Leu Ala Pro 
    130                 135                 140


Ser His Met Ala Ala Ala Thr Gly Asp Met Pro Thr Tyr Gln Ile Arg 
145                 150                 155                 160


Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser Pro 
                165                 170                 175


Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala Thr Arg Lys 
            180                 185                 190


Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Arg Glu Cys Arg 
        195                 200                 205


Arg Lys Lys Lys Glu Tyr Val Lys Cys Leu Glu Asn Arg Val Ala Val 
    210                 215                 220


Leu Glu Asn Gln Asn Lys Thr Leu Ile Glu Glu Leu Lys Ala Leu Lys 
225                 230                 235                 240


Asp Leu Tyr Cys His Lys Val Glu 
                245


<210>  703
<211>  1938
<212>  DNA
<213>  Homo sapiens

<400>  703
gacccgcctg cctcctcgcg aacttgggac gagttggaaa atcctccctg agagagccgt     60

gcggctcagg ggagcggttt aactcggaaa aggaaaagga atccagaaac aaatgaccat    120

ggaaacagtt gaatcccagc atgatggaag tataacagct tctttgacag agagcaagtc    180

tgctcatgtg cagactcaga ctggccaaaa ttcaatccct gctttagctc aggtagcagc    240

aattgcagag acagatgaat ctgcagaatc agaaggtgta attgattctc ataaacgtag    300

agaaatcctt tcacgaagac cctcttatag gaaaatactg aatgaactgt cctctgatgt    360

gcctggtgtt cccaagattg aagaagagag atcagaggaa gaaggaacac cacctagtat    420

tgctaccatg gcagtaccaa ctagcatata tcagactagc acggggcaat acactgccac    480

tggtgacatg ccaacttacc agatccgagc tcctactgct gctttgccac agggagtggt    540

gatggctgca tcgcccggaa gtttgcacag tccccagcag ctggcagaag aagcaacacg    600

caaacgagag ctgaggctaa tgaaaaacag ggaagctgcc aaagaatgtc gacgtcgaaa    660

gaaagaatat gtaaaatgtc tggagagccg agttgcagtg ctggaagtcc agaacaagaa    720

gcttatagag gaacttgaaa ccttgaaaga catttgttct cccaaaacag attactagaa    780

atatttaact atgaactgaa ggcagcatgt atagttgctt ttgaaggaat acaatatata    840

gctggcaaga atggtggctt cttttctttg tatcattcat cttcttcttt aatcacttaa    900

cattcctaaa atgcttcact gtacgtagtt aagtcgtagc tataacttca aattttttaa    960

aagagacaaa ctgtaaaaaa tgtgtgtatt cttaaaatgc aatatttgta aggcttgttc   1020

caatgccaca tacttgcagc tcccattcta tgtgtcatca atagtgtcct atgcaataaa   1080

attatttgca ggtctttaaa tcattttagg aaaggatgat caaaaataat gcatccagca   1140

gtacaataaa agtaaaccac aaaaaaatac ctcaggaaag aatagaaaga aagtctatct   1200

aatgacatgc ctatatgaga agaatagcct agatatgaat atatggcatt tgcagatttt   1260

tatattagtt gctttgttaa aaaaaaaaag attgtattgc tgtccttgaa tgccatagtc   1320

aaagagagtt tttaatagaa ccatgttggt tgcactttgt agtgtttggt gctcatttaa   1380

atatctgaac atttactaca gtttttaact ctactgtgta atataaaaga tcttgcagaa   1440

gttcttagtg ttggtttaat attacctaat gaaagtgatg acatattttt tatatctgga   1500

atgagcctgt tgggatcgca ttgcatacct tcggggtaca agtcagtttc tacactgggt   1560

gctgatcctt gcacgcgccc tttctaccat ctcacggtgg ggatggccgc agggctgtgc   1620

acccagaaga agatggctgt tagcgtttcg gccttcataa tggcctgaga ctttctttct   1680

gtaggtggtc tggagctgtc cggctggtgg ccccctattt tgccatttag cgaacaacca   1740

caggaatttt aaaaacaaaa acatcccaag attttttcat ttcaaaatgc ttcaaagtcc   1800

acattagatc agatactccg ctgtcggcac attcagctga ggttcattac aatcgagact   1860

gcaatgtgat ctatgtttca tcttgttttt ataataaaaa gcttcaggga acaagcccaa   1920

agccctcacc acaaaaaa                                                 1938


<210>  704
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  704

Met Thr Met Glu Thr Val Glu Ser Gln His Asp Gly Ser Ile Thr Ala 
1               5                   10                  15


Ser Leu Thr Glu Ser Lys Ser Ala His Val Gln Thr Gln Thr Gly Gln 
            20                  25                  30


Asn Ser Ile Pro Ala Leu Ala Gln Val Ala Ala Ile Ala Glu Thr Asp 
        35                  40                  45


Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg Glu 
    50                  55                  60


Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu Ser 
65                  70                  75                  80


Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu Glu 
                85                  90                  95


Glu Gly Thr Pro Pro Ser Ile Ala Thr Met Ala Val Pro Thr Ser Ile 
            100                 105                 110


Tyr Gln Thr Ser Thr Gly Gln Tyr Thr Ala Thr Gly Asp Met Pro Thr 
        115                 120                 125


Tyr Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met 
    130                 135                 140


Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu 
145                 150                 155                 160


Ala Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala 
                165                 170                 175


Lys Glu Cys Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser 
            180                 185                 190


Arg Val Ala Val Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu 
        195                 200                 205


Glu Thr Leu Lys Asp Ile Cys Ser Pro Lys Thr Asp Tyr 
    210                 215                 220


<210>  705
<211>  522
<212>  DNA
<213>  Homo sapiens

<400>  705
atggccctaa aaaggcaaga ctcaggcaga agggaaaatg cgccttccga gagcggtcgc     60

ggctctgccc ttcccactcc ggagactgcc cgcgcccggg accgaatgac tcagctgcga    120

ggccctccgg cccagttaaa ccgctcccct gagccgcacg gctctctcag ggaggatttt    180

ccaactcgtc ccaagttcgc gaggaggcag gcgggtcccg gggcagctga gcgcacgaag    240

cgggcgtggg gcggcgagcc ggcggcctcg ggggcgccga gcgaggggcc gcgtcaggtg    300

aactcgcggc tgccccgcca gtccttggcc cggccccggg gtcccggccc gccgcccacg    360

gctccgctcg gcctctgctg ctccaccgca cccggctccg ctccgcctcc tgcctccacc    420

tccacctcct gcgccgcgtc gcccgctgct gggtctcggg gccggagccg acgcaccact    480

tacccgccgc aaagggattt acgtagcgga cctcgtcact ga                       522


<210>  706
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  706

Met Ala Leu Lys Arg Gln Asp Ser Gly Arg Arg Glu Asn Ala Pro Ser 
1               5                   10                  15


Glu Ser Gly Arg Gly Ser Ala Leu Pro Thr Pro Glu Thr Ala Arg Ala 
            20                  25                  30


Arg Asp Arg Met Thr Gln Leu Arg Gly Pro Pro Ala Gln Leu Asn Arg 
        35                  40                  45


Ser Pro Glu Pro His Gly Ser Leu Arg Glu Asp Phe Pro Thr Arg Pro 
    50                  55                  60


Lys Phe Ala Arg Arg Gln Ala Gly Pro Gly Ala Ala Glu Arg Thr Lys 
65                  70                  75                  80


Arg Ala Trp Gly Gly Glu Pro Ala Ala Ser Gly Ala Pro Ser Glu Gly 
                85                  90                  95


Pro Arg Gln Val Asn Ser Arg Leu Pro Arg Gln Ser Leu Ala Arg Pro 
            100                 105                 110


Arg Gly Pro Gly Pro Pro Pro Thr Ala Pro Leu Gly Leu Cys Cys Ser 
        115                 120                 125


Thr Ala Pro Gly Ser Ala Pro Pro Pro Ala Ser Thr Ser Thr Ser Cys 
    130                 135                 140


Ala Ala Ser Pro Ala Ala Gly Ser Arg Gly Arg Ser Arg Arg Thr Thr 
145                 150                 155                 160


Tyr Pro Pro Gln Arg Asp Leu Arg Ser Gly Pro Arg His 
                165                 170


<210>  707
<211>  2604
<212>  DNA
<213>  Homo sapiens

<400>  707
ctcggtgtcc tcccgcggag gggcgtaggg tgtaaacagg cgacgcgctg ggggaggtgc     60

ggccttgctg cgtccacgtc tcgggcatgc tcgaggcggg ccagggcggt agcgccgcca    120

gctcagagcc cacctgaggt aactcctgcg gcctctagga tcggagtccc ccacgccgcg    180

cgcagccgcc gccgctggcc gccaataagg gcggccgagc ccccggcccg ggcagggggt    240

gtggctgccg gcagcgcgtc ggctacaggt gggctgggct gggctgggct gggctgggct    300

gggtgggggc ggccgccaag gacccatccc tgcgctgcgg gcccggcgtg gagcccgcgg    360

agaggcagcg cgactccagg cagtgggtct ctctgccccg gtgctcgcgt ctgcccctgg    420

ggccgggccg agcggaacca ggaatcgcag aaacggtcag cgcccagggc tctaggccgg    480

ccgccccggg tgccaggtga attcctttcc ctgaccggct gtgagacgtt ggcccgtcag    540

ccgtcgtctt tggcctgagt gtgcacatct gtaaaatgga agctcggact agtgatccgt    600

gaggaccttc cacgtctgac gtgtgatctc gagagacctg cgtacattcg gggtgccaga    660

aggaaagcat agagatgggg tcttgctgtg ttgcccagac tggtctcaaa ctcctggcct    720

caagtgatcc ttctgcctca gcttcccaaa gtactgggat tacagcttga aatccatggc    780

ccaaaatgac tctaccagtg gagactctct tctgtgaaga agacgaccag ataagaggtt    840

gggatgagca tgccactgca tcagatctct gccattccat cccaggatgc catctctgct    900

agagtctaca gaagtaagac caaagaaaag gagagggaag aacagaatga gaagactttg    960

ggacatttca tgagtcattc aagcaacatt tctaaggctg ggagtcctcc gtcagcatca   1020

gctccggctc cggtgtcctc cttctctcgc acttctatca cgccatccag ccaggacatc   1080

tgcaggatct gccactgtga aggagatgat gagagccccc tgatcacccc ctgccactgc   1140

acaggaagcc tccacttcgt gcaccaggcc tgcctgcagc agtggatcaa gagctccgac   1200

acgcgctgct gcgagctctg caagtatgag ttcatcatgg agaccaagct gaagccactg   1260

agaaaatggg agaagttgca gatgacgtcc agcgagcgca ggaagatcat gtgctcagtg   1320

acattccacg tcattgccat cacatgtgtg gtctggtcct tgtatgtgct cattgaccgt   1380

actgctgagg agatcaagca ggggcaggca acaggaatcc tagaatggcc cttttggact   1440

aaattggtgg ttgtggccat cggcttcacc ggaggacttc tttttatgta tgttcagtgt   1500

aaagtgtatg tgcaattgtg gaagagactc aaggcctata atagagtgat ctatgttcaa   1560

aactgtccag aaacaagcaa aaagaatatt tttgaaaaat ctccactaac agagcccaac   1620

tttgaaaata aacatggata tggaatctgt cattccgaca caaactcttc ttgttgcaca   1680

gagcctgaag acactggagc agaaatcatt cacgtctgat tgtgtgcggg ttgtcatttt   1740

cctggacatc catgaagagc tgaaggaaat tgtttactgc caattgtata cctttcttat   1800

gtcctttaat agcatagact ggacaggtga ctatttatag tggcttctct ttttctaaac   1860

cctccttagt ctcctagaaa accttcctgt gggccaggca tgcctgggtc ctgcctctgc   1920

ctggcagctc tgtgggaaag tggaagaccc catgatgaca tcatggggag ccagcagagt   1980

tcctgcccat ggtcttgagc tgaatgagag aataaaatgc caatcccaag ggaagaggag   2040

gagcaggggt gcccaggccc tgatacccag ccgcctccag cttgcagtgg tccccagcct   2100

ggagcagagc attggggagt gtctagccat gacgagaaga ttccctctgc atcacggcga   2160

accccaggag atggtattga aacagacccc caaacacaga ctcctgcctg ccctctgccg   2220

atgctgcctc ctccatgctc ttgagcaggt ggagccatgg tgctctgtgg tggcgcatga   2280

ttcactgagc aaacagcact ttacagaaga aaatctttat tttgtaatat gtgtgtccag   2340

cgggattgac actcaaaaaa agtctcactt agaaatcttc ccttccttac ctttgtatct   2400

cctttacatc atgagagatc aaaaatccat tttgccttac atatgctaag aagcgtggca   2460

ttctttctgt tcataaaaca gactcatgac ttttaagaca ggacaagcag gccagaggct   2520

ttttttttaa tcacagatct catgggaatt agtggatgct aaatggcaat taaagcatga   2580

ttcctatgca aaaaaaaaaa aaaa                                          2604


<210>  708
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  708

Met Ser Met Pro Leu His Gln Ile Ser Ala Ile Pro Ser Gln Asp Ala 
1               5                   10                  15


Ile Ser Ala Arg Val Tyr Arg Ser Lys Thr Lys Glu Lys Glu Arg Glu 
            20                  25                  30


Glu Gln Asn Glu Lys Thr Leu Gly His Phe Met Ser His Ser Ser Asn 
        35                  40                  45


Ile Ser Lys Ala Gly Ser Pro Pro Ser Ala Ser Ala Pro Ala Pro Val 
    50                  55                  60


Ser Ser Phe Ser Arg Thr Ser Ile Thr Pro Ser Ser Gln Asp Ile Cys 
65                  70                  75                  80


Arg Ile Cys His Cys Glu Gly Asp Asp Glu Ser Pro Leu Ile Thr Pro 
                85                  90                  95


Cys His Cys Thr Gly Ser Leu His Phe Val His Gln Ala Cys Leu Gln 
            100                 105                 110


Gln Trp Ile Lys Ser Ser Asp Thr Arg Cys Cys Glu Leu Cys Lys Tyr 
        115                 120                 125


Glu Phe Ile Met Glu Thr Lys Leu Lys Pro Leu Arg Lys Trp Glu Lys 
    130                 135                 140


Leu Gln Met Thr Ser Ser Glu Arg Arg Lys Ile Met Cys Ser Val Thr 
145                 150                 155                 160


Phe His Val Ile Ala Ile Thr Cys Val Val Trp Ser Leu Tyr Val Leu 
                165                 170                 175


Ile Asp Arg Thr Ala Glu Glu Ile Lys Gln Gly Gln Ala Thr Gly Ile 
            180                 185                 190


Leu Glu Trp Pro Phe Trp Thr Lys Leu Val Val Val Ala Ile Gly Phe 
        195                 200                 205


Thr Gly Gly Leu Leu Phe Met Tyr Val Gln Cys Lys Val Tyr Val Gln 
    210                 215                 220


Leu Trp Lys Arg Leu Lys Ala Tyr Asn Arg Val Ile Tyr Val Gln Asn 
225                 230                 235                 240


Cys Pro Glu Thr Ser Lys Lys Asn Ile Phe Glu Lys Ser Pro Leu Thr 
                245                 250                 255


Glu Pro Asn Phe Glu Asn Lys His Gly Tyr Gly Ile Cys His Ser Asp 
            260                 265                 270


Thr Asn Ser Ser Cys Cys Thr Glu Pro Glu Asp Thr Gly Ala Glu Ile 
        275                 280                 285


Ile His Val 
    290


<210>  709
<211>  2000
<212>  DNA
<213>  Homo sapiens

<400>  709
atggtaggta tagggctgtg gatatcgtca gtttgaccaa gtattccaag aggccccatg     60

gagtttgtca tctgtaatag aggacgttag tgcattagtg atgaaaaaac tgcttaccac    120

tgactattgt gatctcccag ggagtataag gcagctccgc acttgaaatc catggcccaa    180

aatgactcta ccagtggaga ctctcttctg tgaagaagac gaccagataa gaggttggga    240

tgagcatgcc actgcatcag atctctgcca ttccatccca ggatgccatc tctgctagag    300

tctacagaag taagaccaaa gaaaaggaga gggaagaaca gaatgagaag actttgggac    360

atttcatgag tcattcaagc aacatttcta aggctgggag tcctccgtca gcatcagctc    420

cggctccggt gtcctccttc tctcgcactt ctatcacgcc atccagccag gacatctgca    480

ggatctgcca ctgtgaagga gatgatgaga gccccctgat caccccctgc cactgcacag    540

gaagcctcca cttcgtgcac caggcctgcc tgcagcagtg gatcaagagc tccgacacgc    600

gctgctgcga gctctgcaag tatgagttca tcatggagac caagctgaag ccactgagaa    660

aatgggagaa gttgcagatg acgtccagcg agcgcaggaa gatcatgtgc tcagtgacat    720

tccacgtcat tgccatcaca tgtgtggtct ggtccttgta tgtgctcatt gaccgtactg    780

ctgaggagat caagcagggg caggcaacag gaatcctaga atggcccttt tggactaaat    840

tggtggttgt ggccatcggc ttcaccggag gacttctttt tatgtatgtt cagtgtaaag    900

tgtatgtgca attgtggaag agactcaagg cctataatag agtgatctat gttcaaaact    960

gtccagaaac aagcaaaaag aatatttttg aaaaatctcc actaacagag cccaactttg   1020

aaaataaaca tggatatgga atctgtcatt ccgacacaaa ctcttcttgt tgcacagagc   1080

ctgaagacac tggagcagaa atcattcacg tctgattgtg tgcgggttgt cattttcctg   1140

gacatccatg aagagctgaa ggaaattgtt tactgccaat tgtatacctt tcttatgtcc   1200

tttaatagca tagactggac aggtgactat ttatagtggc ttctcttttt ctaaaccctc   1260

cttagtctcc tagaaaacct tcctgtgggc caggcatgcc tgggtcctgc ctctgcctgg   1320

cagctctgtg ggaaagtgga agaccccatg atgacatcat ggggagccag cagagttcct   1380

gcccatggtc ttgagctgaa tgagagaata aaatgccaat cccaagggaa gaggaggagc   1440

aggggtgccc aggccctgat acccagccgc ctccagcttg cagtggtccc cagcctggag   1500

cagagcattg gggagtgtct agccatgacg agaagattcc ctctgcatca cggcgaaccc   1560

caggagatgg tattgaaaca gacccccaaa cacagactcc tgcctgccct ctgccgatgc   1620

tgcctcctcc atgctcttga gcaggtggag ccatggtgct ctgtggtggc gcatgattca   1680

ctgagcaaac agcactttac agaagaaaat ctttattttg taatatgtgt gtccagcggg   1740

attgacactc aaaaaaagtc tcacttagaa atcttccctt ccttaccttt gtatctcctt   1800

tacatcatga gagatcaaaa atccattttg ccttacatat gctaagaagc gtggcattct   1860

ttctgttcat aaaacagact catgactttt aagacaggac aagcaggcca gaggcttttt   1920

ttttaatcac agatctcatg ggaattagtg gatgctaaat ggcaattaaa gcatgattcc   1980

tatgcaaaaa aaaaaaaaaa                                               2000


<210>  710
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  710

Met Ser Met Pro Leu His Gln Ile Ser Ala Ile Pro Ser Gln Asp Ala 
1               5                   10                  15


Ile Ser Ala Arg Val Tyr Arg Ser Lys Thr Lys Glu Lys Glu Arg Glu 
            20                  25                  30


Glu Gln Asn Glu Lys Thr Leu Gly His Phe Met Ser His Ser Ser Asn 
        35                  40                  45


Ile Ser Lys Ala Gly Ser Pro Pro Ser Ala Ser Ala Pro Ala Pro Val 
    50                  55                  60


Ser Ser Phe Ser Arg Thr Ser Ile Thr Pro Ser Ser Gln Asp Ile Cys 
65                  70                  75                  80


Arg Ile Cys His Cys Glu Gly Asp Asp Glu Ser Pro Leu Ile Thr Pro 
                85                  90                  95


Cys His Cys Thr Gly Ser Leu His Phe Val His Gln Ala Cys Leu Gln 
            100                 105                 110


Gln Trp Ile Lys Ser Ser Asp Thr Arg Cys Cys Glu Leu Cys Lys Tyr 
        115                 120                 125


Glu Phe Ile Met Glu Thr Lys Leu Lys Pro Leu Arg Lys Trp Glu Lys 
    130                 135                 140


Leu Gln Met Thr Ser Ser Glu Arg Arg Lys Ile Met Cys Ser Val Thr 
145                 150                 155                 160


Phe His Val Ile Ala Ile Thr Cys Val Val Trp Ser Leu Tyr Val Leu 
                165                 170                 175


Ile Asp Arg Thr Ala Glu Glu Ile Lys Gln Gly Gln Ala Thr Gly Ile 
            180                 185                 190


Leu Glu Trp Pro Phe Trp Thr Lys Leu Val Val Val Ala Ile Gly Phe 
        195                 200                 205


Thr Gly Gly Leu Leu Phe Met Tyr Val Gln Cys Lys Val Tyr Val Gln 
    210                 215                 220


Leu Trp Lys Arg Leu Lys Ala Tyr Asn Arg Val Ile Tyr Val Gln Asn 
225                 230                 235                 240


Cys Pro Glu Thr Ser Lys Lys Asn Ile Phe Glu Lys Ser Pro Leu Thr 
                245                 250                 255


Glu Pro Asn Phe Glu Asn Lys His Gly Tyr Gly Ile Cys His Ser Asp 
            260                 265                 270


Thr Asn Ser Ser Cys Cys Thr Glu Pro Glu Asp Thr Gly Ala Glu Ile 
        275                 280                 285


Ile His Val 
    290


<210>  711
<211>  2511
<212>  DNA
<213>  Homo sapiens

<400>  711
ctcggtgtcc tcccgcggag gggcgtaggg tgtaaacagg cgacgcgctg ggggaggtgc     60

ggccttgctg cgtccacgtc tcgggcatgc tcgaggcggg ccagggcggt agcgccgcca    120

gctcagagcc cacctgaggt aactcctgcg gcctctagga tcggagtccc ccacgccgcg    180

cgcagccgcc gccgctggcc gccaataagg gcggccgagc ccccggcccg ggcagggggt    240

gtggctgccg gcagcgcgtc ggctacaggt gggctgggct gggctgggct gggctgggct    300

gggtgggggc ggccgccaag gacccatccc tgcgctgcgg gcccggcgtg gagcccgcgg    360

agaggcagcg cgactccagg cagtgggtct ctctgccccg gtgctcgcgt ctgcccctgg    420

ggccgggccg agcggaacca ggaatcgcag aaacggtcag cgcccagggc tctaggccgg    480

ccgccccggg tgccaggtga attcctttcc ctgaccggct gtgagacgtt ggcccgtcag    540

ccgtcgtctt tggcctgagt gtgcacatct gtaaaatgga agctcggact agtgatccgt    600

gaggaccttc cacgtctgac gtgtgatctc gagagacctg cgtacattcg gggtgccaga    660

aggaaagcat agcttgaaat ccatggccca aaatgactct accagtggag actctcttct    720

gtgaagaaga cgaccagata agaggttggg atgagcatgc cactgcatca gatctctgcc    780

attccatccc aggatgccat ctctgctaga gtctacagaa gtaagaccaa agaaaaggag    840

agggaagaac agaatgagaa gactttggga catttcatga gtcattcaag caacatttct    900

aaggctggga gtcctccgtc agcatcagct ccggctccgg tgtcctcctt ctctcgcact    960

tctatcacgc catccagcca ggacatctgc aggatctgcc actgtgaagg agatgatgag   1020

agccccctga tcaccccctg ccactgcaca ggaagcctcc acttcgtgca ccaggcctgc   1080

ctgcagcagt ggatcaagag ctccgacacg cgctgctgcg agctctgcaa gtatgagttc   1140

atcatggaga ccaagctgaa gccactgaga aaatgggaga agttgcagat gacgtccagc   1200

gagcgcagga agatcatgtg ctcagtgaca ttccacgtca ttgccatcac atgtgtggtc   1260

tggtccttgt atgtgctcat tgaccgtact gctgaggaga tcaagcaggg gcaggcaaca   1320

ggaatcctag aatggccctt ttggactaaa ttggtggttg tggccatcgg cttcaccgga   1380

ggacttcttt ttatgtatgt tcagtgtaaa gtgtatgtgc aattgtggaa gagactcaag   1440

gcctataata gagtgatcta tgttcaaaac tgtccagaaa caagcaaaaa gaatattttt   1500

gaaaaatctc cactaacaga gcccaacttt gaaaataaac atggatatgg aatctgtcat   1560

tccgacacaa actcttcttg ttgcacagag cctgaagaca ctggagcaga aatcattcac   1620

gtctgattgt gtgcgggttg tcattttcct ggacatccat gaagagctga aggaaattgt   1680

ttactgccaa ttgtatacct ttcttatgtc ctttaatagc atagactgga caggtgacta   1740

tttatagtgg cttctctttt tctaaaccct ccttagtctc ctagaaaacc ttcctgtggg   1800

ccaggcatgc ctgggtcctg cctctgcctg gcagctctgt gggaaagtgg aagaccccat   1860

gatgacatca tggggagcca gcagagttcc tgcccatggt cttgagctga atgagagaat   1920

aaaatgccaa tcccaaggga agaggaggag caggggtgcc caggccctga tacccagccg   1980

cctccagctt gcagtggtcc ccagcctgga gcagagcatt ggggagtgtc tagccatgac   2040

gagaagattc cctctgcatc acggcgaacc ccaggagatg gtattgaaac agacccccaa   2100

acacagactc ctgcctgccc tctgccgatg ctgcctcctc catgctcttg agcaggtgga   2160

gccatggtgc tctgtggtgg cgcatgattc actgagcaaa cagcacttta cagaagaaaa   2220

tctttatttt gtaatatgtg tgtccagcgg gattgacact caaaaaaagt ctcacttaga   2280

aatcttccct tccttacctt tgtatctcct ttacatcatg agagatcaaa aatccatttt   2340

gccttacata tgctaagaag cgtggcattc tttctgttca taaaacagac tcatgacttt   2400

taagacagga caagcaggcc agaggctttt tttttaatca cagatctcat gggaattagt   2460

ggatgctaaa tggcaattaa agcatgattc ctatgcaaaa aaaaaaaaaa a            2511


<210>  712
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  712

Met Ser Met Pro Leu His Gln Ile Ser Ala Ile Pro Ser Gln Asp Ala 
1               5                   10                  15


Ile Ser Ala Arg Val Tyr Arg Ser Lys Thr Lys Glu Lys Glu Arg Glu 
            20                  25                  30


Glu Gln Asn Glu Lys Thr Leu Gly His Phe Met Ser His Ser Ser Asn 
        35                  40                  45


Ile Ser Lys Ala Gly Ser Pro Pro Ser Ala Ser Ala Pro Ala Pro Val 
    50                  55                  60


Ser Ser Phe Ser Arg Thr Ser Ile Thr Pro Ser Ser Gln Asp Ile Cys 
65                  70                  75                  80


Arg Ile Cys His Cys Glu Gly Asp Asp Glu Ser Pro Leu Ile Thr Pro 
                85                  90                  95


Cys His Cys Thr Gly Ser Leu His Phe Val His Gln Ala Cys Leu Gln 
            100                 105                 110


Gln Trp Ile Lys Ser Ser Asp Thr Arg Cys Cys Glu Leu Cys Lys Tyr 
        115                 120                 125


Glu Phe Ile Met Glu Thr Lys Leu Lys Pro Leu Arg Lys Trp Glu Lys 
    130                 135                 140


Leu Gln Met Thr Ser Ser Glu Arg Arg Lys Ile Met Cys Ser Val Thr 
145                 150                 155                 160


Phe His Val Ile Ala Ile Thr Cys Val Val Trp Ser Leu Tyr Val Leu 
                165                 170                 175


Ile Asp Arg Thr Ala Glu Glu Ile Lys Gln Gly Gln Ala Thr Gly Ile 
            180                 185                 190


Leu Glu Trp Pro Phe Trp Thr Lys Leu Val Val Val Ala Ile Gly Phe 
        195                 200                 205


Thr Gly Gly Leu Leu Phe Met Tyr Val Gln Cys Lys Val Tyr Val Gln 
    210                 215                 220


Leu Trp Lys Arg Leu Lys Ala Tyr Asn Arg Val Ile Tyr Val Gln Asn 
225                 230                 235                 240


Cys Pro Glu Thr Ser Lys Lys Asn Ile Phe Glu Lys Ser Pro Leu Thr 
                245                 250                 255


Glu Pro Asn Phe Glu Asn Lys His Gly Tyr Gly Ile Cys His Ser Asp 
            260                 265                 270


Thr Asn Ser Ser Cys Cys Thr Glu Pro Glu Asp Thr Gly Ala Glu Ile 
        275                 280                 285


Ile His Val 
    290


<210>  713
<211>  3256
<212>  DNA
<213>  Homo sapiens

<400>  713
cggactgctg tcctccagat tcaggccggt gggtctgggg agcccggatt ggtcttggag     60

gagcaacggc tgcgcaggtg actcggtggc ctcaagtgtg tacaaaactc aaaacatgaa    120

caacaatata tattaccaat cttcaaacct ggtttgccta gaactggaat acagttgcct    180

gcgacatatt ttagaagaac tagaaaagtc aaagtaatgg ataacagaaa agagcctcca    240

ttcttcaatg atgataacat gggaccattt tactacagac ttcatttctg tgataccatg    300

gagctcttca ttgaaacatt aactggaaca tgttttgagc tgagagtttc accttttgaa    360

actgttattt ctgtgaaagc aaaaattcga agattggaag gtattcccat ctgtcgacaa    420

cacttaattt ggaataacat ggaacttgaa aatgattatt gcttgaatga ttacaacatt    480

tcagaagggt gtaccttgaa gctagttttg gctatgcgtg gcggacctat aaatactaga    540

agagttccta cagacgatcc acttaggaag atggcagagt acttggattc cagtcgagtt    600

gaggtctggg agaagacctc ctgcagcaaa caagttacat ttttggtata ccgagaagga    660

gatcaattga atttctttcc tgcagtagat aggggagatg gcactttaac accgttatct    720

gactcttcaa agaaaataga ttttcatttg catgtcctac ggagaaaagg agaacatcgt    780

atgagtggtg gttctatgta taattcagat acagatgagg atgaagaaac tgagccttct    840

tcttctgggc aacagataat tgaaaattca ataactatga ataagatgaa gctgctgaag    900

gctaagatga agaacatgaa tctcagcaaa aagcctaaga aagctgtcaa gataaaacct    960

cacccacctg tagctcctcg accttctagt ggttccactg caccatctcg ccaccgattg   1020

ttaagggtcc tccccaacat tggtcaatct tgttcacctg cttttgggaa tgcatatccg   1080

cccgaaatct ccaggaatgg aatttcaagt ttggcaactc aactctctgc tgagagatac   1140

atatcttcta tcactggtga atttcttaag gaagataata gctgggagaa taacacactg   1200

tctcacttca gtagcaacgt caaactacct cctcagatac cccatttgga gttgggaaat   1260

gaccaggagc ttgctgactc tgttctccat cttggatcat ccctgcctag gcaaacaaaa   1320

cattttttag gaaacttgcc atctagtaat gggaacattg tcttaccttc agaagaatgt   1380

gtaaccgaac aatcacttct acctaaagtg ggctcaccgg cttcatttgc agaaggaaat   1440

gctgatgaac agagcagcgg cttagaaggt gcgtgcaaag tgaatctgga gttgctactc   1500

actaatgctg acaaagggtt gaaagctcca gagcagcatc tcaagcatgt tgcaggagtg   1560

ctgaatgggg aatcagtaga gacttcagtt cttaactacc gggaattaag tcctcacaag   1620

aatagactct tgtcacctct tcgctgttct gcatcaatgt cgctacataa ttctctggtg   1680

aaaccagaga gacagtccaa atgttttgag tttgggaagc tacagccttc ttcttctcag   1740

tcactggatg ttcaaaacat aactgattct tctttctcta ggactacttg ctttcaaggt   1800

gttaaagttg attcacttgg gaaaagatct gatgttattt ccaaagttga ggctcgggat   1860

atcacagaaa tgactaacaa ggcttccaaa gagcctgttg gttgtgtaaa taatatcagt   1920

tttcttgcct cactggccgg gagcacaagc agaaatagat tacagagcac acgtggggca   1980

ggcaggcttc agaactctgg aactgggctg tctacaaacc tccagcattt tcaggaagaa   2040

aactttagga aaagttctcc ccagttagaa catacaggag tttttttgtc tacccatggt   2100

gttggaatga atggaaataa tgcagcagca gggaaaagcg taggagaatg tactactcat   2160

cacctcccac ctgtgaaagc ccctcttcag acaaagaaga aaacaacaaa tcattgtttt   2220

ctttgtggaa agaaaacagg actggctagt agctacgaat gcagatgtgg aaacaacttc   2280

tgtgcatctc atcgttatgc agaaactcat ggctgtacct atgattacaa gagtgcaggg   2340

aggagatact tgcacgaggc aaatcctgtg gttaatgcac caaagcttcc aaaaatctaa   2400

ctcttcctct acatcttact gttctgcccg ggattcgtat tataatgaca gaagaaatgt   2460

tgtttagact attatttttg ttcgactcta aaagatttgc caaataacaa aagcatacaa   2520

tgcatactgt tggagaacaa gaatgctact gtattttaca tctttatttc ttggtgaaac   2580

aaaagtttta aaagtagttt taacaacttt acactggaat gatttagctt tgttattgca   2640

tgtcttgtgt taagtgtttt gtatatgata ttgcagtttt actaggcaaa tcttcaaaag   2700

atgcacttta ggaaacgaaa tatttcctaa ataaccaggc ttccacattg tacagaatga   2760

gcagtcatgt aatgaatggc tctactcaga ttgaccatat gggttttttc tttttctttc   2820

ttttattctt ctccttcttt ttttttcaga ggtgggatgg gtggagattt tttaaaaatc   2880

ccacgtgtga aagtttactg gctttattag caagttcctt tttacttcaa gctacttttt   2940

ataaaaaaga acatttttcc agtgtggttt ttaacagata atacatttct tccacattca   3000

gattagattc ggacatgaat ccattctata aaacacatcg tgttcatgat agtgtatatt   3060

ttactacttt ttgaatgtta attttaaaat agaagatgtc ccacttgcca ttaaatatag   3120

aagccaactt tttacctttt gaaatatggc tacatttaaa acaaaatctc acagctcggt   3180

ttttcttatt tgttgagtgc tattaccagg agaaatacaa ataaatattc aatttcatta   3240

aaaaaaaaaa aaaaaa                                                   3256


<210>  714
<211>  727
<212>  PRT
<213>  Homo sapiens

<400>  714

Met Asp Asn Arg Lys Glu Pro Pro Phe Phe Asn Asp Asp Asn Met Gly 
1               5                   10                  15


Pro Phe Tyr Tyr Arg Leu His Phe Cys Asp Thr Met Glu Leu Phe Ile 
            20                  25                  30


Glu Thr Leu Thr Gly Thr Cys Phe Glu Leu Arg Val Ser Pro Phe Glu 
        35                  40                  45


Thr Val Ile Ser Val Lys Ala Lys Ile Arg Arg Leu Glu Gly Ile Pro 
    50                  55                  60


Ile Cys Arg Gln His Leu Ile Trp Asn Asn Met Glu Leu Glu Asn Asp 
65                  70                  75                  80


Tyr Cys Leu Asn Asp Tyr Asn Ile Ser Glu Gly Cys Thr Leu Lys Leu 
                85                  90                  95


Val Leu Ala Met Arg Gly Gly Pro Ile Asn Thr Arg Arg Val Pro Thr 
            100                 105                 110


Asp Asp Pro Leu Arg Lys Met Ala Glu Tyr Leu Asp Ser Ser Arg Val 
        115                 120                 125


Glu Val Trp Glu Lys Thr Ser Cys Ser Lys Gln Val Thr Phe Leu Val 
    130                 135                 140


Tyr Arg Glu Gly Asp Gln Leu Asn Phe Phe Pro Ala Val Asp Arg Gly 
145                 150                 155                 160


Asp Gly Thr Leu Thr Pro Leu Ser Asp Ser Ser Lys Lys Ile Asp Phe 
                165                 170                 175


His Leu His Val Leu Arg Arg Lys Gly Glu His Arg Met Ser Gly Gly 
            180                 185                 190


Ser Met Tyr Asn Ser Asp Thr Asp Glu Asp Glu Glu Thr Glu Pro Ser 
        195                 200                 205


Ser Ser Gly Gln Gln Ile Ile Glu Asn Ser Ile Thr Met Asn Lys Met 
    210                 215                 220


Lys Leu Leu Lys Ala Lys Met Lys Asn Met Asn Leu Ser Lys Lys Pro 
225                 230                 235                 240


Lys Lys Ala Val Lys Ile Lys Pro His Pro Pro Val Ala Pro Arg Pro 
                245                 250                 255


Ser Ser Gly Ser Thr Ala Pro Ser Arg His Arg Leu Leu Arg Val Leu 
            260                 265                 270


Pro Asn Ile Gly Gln Ser Cys Ser Pro Ala Phe Gly Asn Ala Tyr Pro 
        275                 280                 285


Pro Glu Ile Ser Arg Asn Gly Ile Ser Ser Leu Ala Thr Gln Leu Ser 
    290                 295                 300


Ala Glu Arg Tyr Ile Ser Ser Ile Thr Gly Glu Phe Leu Lys Glu Asp 
305                 310                 315                 320


Asn Ser Trp Glu Asn Asn Thr Leu Ser His Phe Ser Ser Asn Val Lys 
                325                 330                 335


Leu Pro Pro Gln Ile Pro His Leu Glu Leu Gly Asn Asp Gln Glu Leu 
            340                 345                 350


Ala Asp Ser Val Leu His Leu Gly Ser Ser Leu Pro Arg Gln Thr Lys 
        355                 360                 365


His Phe Leu Gly Asn Leu Pro Ser Ser Asn Gly Asn Ile Val Leu Pro 
    370                 375                 380


Ser Glu Glu Cys Val Thr Glu Gln Ser Leu Leu Pro Lys Val Gly Ser 
385                 390                 395                 400


Pro Ala Ser Phe Ala Glu Gly Asn Ala Asp Glu Gln Ser Ser Gly Leu 
                405                 410                 415


Glu Gly Ala Cys Lys Val Asn Leu Glu Leu Leu Leu Thr Asn Ala Asp 
            420                 425                 430


Lys Gly Leu Lys Ala Pro Glu Gln His Leu Lys His Val Ala Gly Val 
        435                 440                 445


Leu Asn Gly Glu Ser Val Glu Thr Ser Val Leu Asn Tyr Arg Glu Leu 
    450                 455                 460


Ser Pro His Lys Asn Arg Leu Leu Ser Pro Leu Arg Cys Ser Ala Ser 
465                 470                 475                 480


Met Ser Leu His Asn Ser Leu Val Lys Pro Glu Arg Gln Ser Lys Cys 
                485                 490                 495


Phe Glu Phe Gly Lys Leu Gln Pro Ser Ser Ser Gln Ser Leu Asp Val 
            500                 505                 510


Gln Asn Ile Thr Asp Ser Ser Phe Ser Arg Thr Thr Cys Phe Gln Gly 
        515                 520                 525


Val Lys Val Asp Ser Leu Gly Lys Arg Ser Asp Val Ile Ser Lys Val 
    530                 535                 540


Glu Ala Arg Asp Ile Thr Glu Met Thr Asn Lys Ala Ser Lys Glu Pro 
545                 550                 555                 560


Val Gly Cys Val Asn Asn Ile Ser Phe Leu Ala Ser Leu Ala Gly Ser 
                565                 570                 575


Thr Ser Arg Asn Arg Leu Gln Ser Thr Arg Gly Ala Gly Arg Leu Gln 
            580                 585                 590


Asn Ser Gly Thr Gly Leu Ser Thr Asn Leu Gln His Phe Gln Glu Glu 
        595                 600                 605


Asn Phe Arg Lys Ser Ser Pro Gln Leu Glu His Thr Gly Val Phe Leu 
    610                 615                 620


Ser Thr His Gly Val Gly Met Asn Gly Asn Asn Ala Ala Ala Gly Lys 
625                 630                 635                 640


Ser Val Gly Glu Cys Thr Thr His His Leu Pro Pro Val Lys Ala Pro 
                645                 650                 655


Leu Gln Thr Lys Lys Lys Thr Thr Asn His Cys Phe Leu Cys Gly Lys 
            660                 665                 670


Lys Thr Gly Leu Ala Ser Ser Tyr Glu Cys Arg Cys Gly Asn Asn Phe 
        675                 680                 685


Cys Ala Ser His Arg Tyr Ala Glu Thr His Gly Cys Thr Tyr Asp Tyr 
    690                 695                 700


Lys Ser Ala Gly Arg Arg Tyr Leu His Glu Ala Asn Pro Val Val Asn 
705                 710                 715                 720


Ala Pro Lys Leu Pro Lys Ile 
                725


<210>  715
<211>  3558
<212>  DNA
<213>  Homo sapiens

<400>  715
ttctgagggt taaatgagca tagcacagtg tcaggcacac actacttgcc agatgtcgag     60

tattcatctt tattgaaata ggactgtggt aagccacttt atggctctcg attttgtatg    120

agaaaatcat gcttagtgcc ttgttagtaa aagaaagaaa acctgaaagt ccctgccacg    180

gaaggaagaa atagcgggga gaaaagggag ttggtaagtt tcagcatttc agagcttgga    240

gagggacaag ttaggtttcc attttatgga gaaggaggtg gaggcaggat gggtcctaag    300

gtgtcattca aaacacacag ccataactct ttattgagag tagcgctagg gccccaggga    360

ttgctgtggt caagttgcgg acaaaaatga ccactcgttg gaagacagga gaggagtgtt    420

tagttacaaa agcagtcaac aattcaggtg tatctatatt cagacagcaa ataaaagttg    480

ttcaacttgg ttgctaatgg gacccactct actgaggctt tgtatagaac tcatagagga    540

agatggcttc aaggaatgaa ctaccctgtg cttttcttag gactaaaatc tcaggaagct    600

ggtgatgaat gaaaacctta gtcccactgg cactgcacga ggggccagga gagcagcagc    660

atcataagcc gcagggtggg gcagccaagg caggggcatt ctgagctgtt ggggaggggt    720

ggcaggcagg gtggggcact gtgagctgtc ggggagggca ttgtgaagtg tggggtgggg    780

cattgtgtgc cacatgcctg ggctcccacc tggggccagt gggcttcagt ctgtaggtga    840

ctacagaagg aggaggagct ccgtctgttc tctcttcagg cagttgttgt gtctctcagc    900

acttgttggg ttcacaacct attaaataag ccggctggtc ttcaccctcc cagacaagtc    960

aactcagggg aggcagcagg gtgcgggcct tggccagggc cagggccagg gccagggcca   1020

gggctggtgc ccggggccgc gctgtgaggt gggcaggcga ggagcgggaa gaccatctct   1080

gcaagtgcag catagcctcg gcctaggaca gcgggagtgc gtggccaaag ctgtgagcag   1140

aggcacaggt ggtggcagac agtagaggca ccccatgggg aacatactga cctgtcgtgt   1200

gcaccctagc gtcagcctcg agtttgacca gcaacagggg tcggtgtgtc cctctgaatc   1260

tgagatctat gaggcagtag ctggggacag gatggcagga gcgcccatgg ctgctgctgt   1320

gcagcctgct gaggtgactg ttgaagttgg tgaggacctc cacatgcacc acgttcgtga   1380

ccgggagatg cctgaagctt tggagtttaa cctttctgcc aatccagagg caagcacaat   1440

attccagagg aactctcaaa cagatgcttt ggagtttaac ccttctgcca atccagaggc   1500

aagcacaata ttccagagga actctcaaac agatgttgta gaaataagaa gaagcaactg   1560

tacaaaccat gtatctactg tgcgtttcag tcaacaatac agcttgtgtt cgacaatatt   1620

ccttgatgac agcacagcca tcagcattat cttacaatga caataatatc tgtgaccttg   1680

gagatacctc atcatatcac acaaagagat gcagatagat ctttgagcat acctgatgaa   1740

cagttacact catttgcggt ttccaccgtg cacattacga agaacagaaa tggaggtggg   1800

agtttaaata actattcctc ctccattcca tcgactccca gcaccagcca ggaggaccct   1860

cagttcagtg ttcctcccac tgccaacaca cccacccccg tttgcaagcg gtccatgcgc   1920

tggtccaacc tgtttacatc tgagaaaggg agtgacccag acaaagagag gaaagccccg   1980

gagaatcatg ctgacaccat cgggagcggc agagccatcc ccattaaaca gggcatgctc   2040

ttaaagcgaa gtgggaaatg gctgaagaca tggaaaaaga aatacgtcac cctgtgttcc   2100

aatggcgtgc tcacctatta ttcaagctta ggtgattata tgaagaatat tcataaaaaa   2160

gagattgacc ttcagacatc taccatcaaa gtcccaggaa agtggccatc cctagccaca   2220

tcggcctgcg cacccatctc cagctctaaa agcaatgacc tatccaagga catggacacc   2280

gggctgggtg actccatatg cttcagcccc agtatctcca gcaccaccgg ccccaagctc   2340

aacccgcccc cctctcctca tgccaataaa aagaaacacc taaagaagaa aagcaccaac   2400

aactttatga ttgtgtctgc cactggccaa acgtggcact ttgaagccac gacatatgag   2460

gagcgggatg cctgggtcca agccatccag agccagatcc tggccagcct gcagtcatgc   2520

gagagcagta aaagcaagtc ccagctgacc agccagagcg aggccatggc cctgcagtcg   2580

atccaaaaca tgcgtgggaa cgcccactgt gtggactgtg agacccagaa tcctaagtgg   2640

gccagtttga acttgggagt cctcatgtgt attgaatgct caggtatcca ccgcagtctt   2700

ggcacccgcc tttcccgtgt gcgatctctg gagctggatg actggccagt tgagctcagg   2760

aaggttatgt catctattgg caatgaccta gccaacagca tctgggaagg gagcagccag   2820

ggacagacaa aaccctcaga aaagtccacg agggaagaaa aggaacggtg gatcctttcc   2880

aaatatgagg agaagctctt tctggcccca ctaccctgca ctgatctgtc cctgggccag   2940

cagctgctgc gggccaccgc tgatgaggac ctgcagacag ccatcctgct gctggcacat   3000

ggctcccgtg aggaggtgaa cgagacctgt ggggagggag acggctgcac ggcgctccat   3060

ctggcctgcc gcaaggggaa tgtggtcctg gcgcagctcc tgatctggta cggggtggac   3120

gtcatggccc gagatgccca cgggaacaca gcgctgacct acgcccggca ggcctccagc   3180

caggagtgca tcaacgtgct tctgcagtac ggctgccccg acgagtgcgt gtagttctgt   3240

tttatttgac tacagtctcc ttggtgcaaa aacaaaatgg gaaaaataag gataactcag   3300

aatttcaaaa ggaaatcaca aattcagctt ataatagcat tttcagtact tctcataaac   3360

taagtaaata cacaaaatgt tgatttttct gaccataaga catattttat gtccttttgc   3420

cgaggtggat gtgttagtct caggccctcc tggccacatt gcccaagtca cacaggcttc   3480

tgtattatgt atttagataa gatgtgtgaa aatatatttg aaaaaaagtt cataaatttg   3540

cattgatttt tgtacaca                                                 3558


<210>  716
<211>  786
<212>  DNA
<213>  Homo sapiens

<400>  716
atgtctttcc acgtcttttt ctttgctttt ataaatatat ctgtttccat agaaatgctt     60

cacatcacac aagtgagtga tgaggaagag gatgatgatg gctgtgacct ttttgctgac    120

tctgagaagg aggagaaaga tattgaggac attgaagaaa atactagacc tgtaaggaag    180

gctgtagttg ctatcacttg gcagggggga tgccgtgggc cgagtggacg aggagccgac    240

aaccttaccc tcaggagaag caaaacttcg gaagacactc aagagaagaa ggaaaggaga    300

actccttcgg acgatgaaga ggataactta ttcgcacccc ccaagctgac cgacgaggac    360

ttctcgccat ttggctctgg aggtggcctg ttcagtgggg gcaaggggct ctttgatgat    420

gaggacgagg agagtgacct cttcacggaa gccccccagg atcggcaagc tggagcctct    480

gttaaggagg agtcttcatc atccaaacct ggaaagaaaa tcctagcagg agctgtttct    540

gtatttttag gagacacgga tgtgctgcct ccgttccatc actgaaggag ccacagaagc    600

ctgagcagcc cactccaagg aaaagcccct atggtccccc tcccactggc ctgtttgatg    660

atgatgatgg tgatgatgat aacgactttt tctcgacacc ccacagcaaa ccttccaaaa    720

caggcaaagt ccaatccact gctgatatct ttggtgatga agaaggagat ctgttcaaag    780

aaaaag                                                               786


<210>  717
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  717

Met Ser Phe His Val Phe Phe Phe Ala Phe Ile Asn Ile Ser Val Ser 
1               5                   10                  15


Ile Glu Met Leu His Ile Thr Gln Val Ser Asp Glu Glu Glu Asp Asp 
            20                  25                  30


Asp Gly Cys Asp Leu Phe Ala Asp Ser Glu Lys Glu Glu Lys Asp Ile 
        35                  40                  45


Glu Asp Ile Glu Glu Asn Thr Arg Pro Val Arg Lys Ala Val Val Ala 
    50                  55                  60


Ile Thr Trp Gln Gly Gly Cys Arg Gly Pro Ser Gly Arg Gly Ala Asp 
65                  70                  75                  80


Asn Leu Thr Leu Arg Arg Ser Lys Thr Ser Glu Asp Thr Gln Glu Lys 
                85                  90                  95


Lys Glu Arg Arg Thr Pro Ser Asp Asp Glu Glu Asp Asn Leu Phe Ala 
            100                 105                 110


Pro Pro Lys Leu Thr Asp Glu Asp Phe Ser Pro Phe Gly Ser Gly Gly 
        115                 120                 125


Gly Leu Phe Ser Gly Gly Lys Gly Leu Phe Asp Asp Glu Asp Glu Glu 
    130                 135                 140


Ser Asp Leu Phe Thr Glu Ala Pro Gln Asp Arg Gln Ala Gly Ala Ser 
145                 150                 155                 160


Val Lys Glu Glu Ser Ser Ser Ser Lys Pro Gly Lys Lys Ile Leu Ala 
                165                 170                 175


Gly Ala Val Ser Val Phe Leu Gly Asp Thr Asp Val Leu Pro Pro Phe 
            180                 185                 190


His His 



<210>  718
<211>  4621
<212>  DNA
<213>  Homo sapiens

<400>  718
gtcacgcccc gggcagcttg gctggggcta ggcttccggg gctctgcggt cctcggcctg     60

tgctggcagc ctcggagccc accgagccgg gcggctggga tgatgaaccg gacgaccccc    120

gaccaggagc tggtgccggc gtcggagccc gtgtgggagc ggccgtggtc ggtggaggag    180

atccgcagga gcagccagag ctggtcgctg gcggccgacg cgggcctact acagtttcta    240

caggaattct cacagcaaac tatctctagg acccatgaaa tcaagaaaca agtggacgga    300

ctaatccggg aaaccaaagc cacagattgt cgcctgcata atgtcttcaa tgacttcctt    360

atgctctcta atacccagtt catagagaat cgtgtatatg atgaagaagt ggaggagcca    420

gtactcaagg ctgaggcaga aaaaacagag caggagaaga cacgagagca gaaagaagta    480

gatctcattc ctaaagtcca ggaggctgtg aactatggct tacaagtatt ggacagtgcc    540

tttgagcaac ttgatatcaa agcaggaaac tcagactccg aggaagatga tgctaatggg    600

cgggtggaac tgatccttga accaaaggat ctatacattg atcgtccttt accatatctc    660

attgggtcaa agctgttcat ggaacaagaa gatgtaggtc ttggagagct gtccagtgaa    720

gaaggctctg taggcagtga tcgtggcagt attgtggaca ctgaggaaga gaaagaagag    780

gaggagtcag atgaagattt tgcccatcac agtgacaatg aacaaaacca gcacaccaca    840

caaatgagtg atgaggaaga ggatgatgat ggctgtgacc tttttgctga ctctgagaag    900

gaggaggaag atattgagga cattgaagaa aatactagac ctaaaagaag cagacctaca    960

tcgtttgcag atgagctggc tgcccgcatc aagggggatg ccatgggtcg agtggacgag   1020

gagccgacaa ccttaccctc aggagaagca aaacctcgga agacactcaa agagaagaag   1080

gaaaggagaa ctccttcaga cgatgaagag gataacttat tcgcaccccc caagctgacc   1140

gacgaggact tctcgccatt tggctctgga ggtggcctgt tcagtggcgg caaggggcta   1200

tttgatgatg aggacgagga gagtgacctc ttcacggaag cctcccagga tcggcaagct   1260

ggagcctctg ttaaggagga gtcttcatca tccaaacctg gaaagaaaat cccagcagga   1320

gctgtttctg tatttttagg agacacggat gtgtttggtg ctgcctccgt tccatcactg   1380

aaggagccac agaagcctga gcagcccact ccaaggaaaa gcccctatgg tccccctccc   1440

actggcctct ttgatgatga tgatggtgat gatgatgacg actttttctc ggcaccccac   1500

agcaaacctt ctaaaacacg caaagtccaa tccactgccg atatctttgg tgacgaagaa   1560

ggagatctgt tcaaagaaaa agccgtagca tcgccagaag ccactgtgag tcagacagat   1620

gaaaataaag caagagcaga aaaaaaggtt accttatctt acagcaaaaa tctcaagccc   1680

tcatcagaaa caaagactca aaaaggctta ttttcagatg aggaggactc tgaggatttg   1740

ttttcttctc aaagtgcgag taacttaaaa ggtgcatctc tgctgcctgg caagctcccc   1800

acgtcggttt ccctgtttga tgatgaagat gaagaggata atctttttgg gggtacagct   1860

gctaagaagc agacattgtc tctacaagct cagagagaag agaaagcaaa agcctccgag   1920

ctctccaaaa agaaagcatc tgccctgttg ttcagcagtg atgaggagtg gaatattcct   1980

gcttcacaga cccacttagc atctgacagc aggtctaaag gagaacccag ggattctggg   2040

accctccaga gccaggaggc caaggctgtg aaaaagacca gtctctttga ggaagacaaa   2100

gaagatgatc tttttgccat tgccaaggac agccaaaaga agacccagag agtgtcactc   2160

ctctttgaag acgatgttga tagcggaggc tctctgtttg gctctcctcc cacatctgtt   2220

cctcctgcaa caaagaaaaa agagactgtc tctgaggcac cacctttgct gttcagcgat   2280

gaagaagaga aggaggcaca acttggagtg aagtctgtgg ataagaaggt tgagagtgcc   2340

aaggagtcat taaaatttgg gagaactgat gtggctgagt cagaaaagga aggacttttg   2400

actagatctg ctcaggaaac agtcaagcat tctgatttat tttcttcatc atccccatgg   2460

gacaaaggaa ccaagcctag aaccaaaact gttcttagct tgtttgatga ggaagaggat   2520

aaaatggaag atcaaaacat tatccaggct ccacagaaag aagtaggaaa gggctgcgat   2580

cctgatgccc accccaagag cacaggtgtc ttccaggatg aagagctgct tttcagccac   2640

aagctccaaa aggacaatga cccagatgtt gacctttttg ctggcaccaa aaaaaccaag   2700

ctgttagagc caagtgttgg gagcctgttt ggggatgatg aagatgatga tcttttcagc   2760

tctgccaagt cccagccttt ggtacaagag aaaaagagag tagtgaaaaa agaccactct   2820

gttaactctt tcaaaaacca gaaacatcct gaatccattc aaggtagtaa agaaaaaggc   2880

atatggaagc cggaaacacc tcaggcaaat ttagcgatca acccagcggc cttgctgccc   2940

acagcggctt cccagatctc tgaagtaaag cctgttttgc cagaattggc ttttccttca   3000

tctgaacaca gaaggagcca cggtctggaa agtgtgcctg tccttcccgg gagtggggag   3060

gccggtgtga gttttgatct tccagctcag gcagacacct tacacagtgc aaacaagagc   3120

cgtgtcaaga tgagagggaa gcgtagaccg cagacccgtg cagctaggcg gctggctgct   3180

caggagtcca gcgaggctga ggacatgagc gtccccagag gacccattgc acagtgggct   3240

gatggcgcca tttccccaaa tggccatcgg ccacagctca gagcagccag tggagaagac   3300

agcactgagg aggccctggc agctgccgct gcaccttggg aaggtggtcc tgtgcctgga   3360

gtggacacaa gcccctttgc aaagtctctg ggtcattcca gaggggaggc tgaccttttt   3420

gattctgggg acattttttc cacgggcact ggatctcagt ccgtggagag aacaaaaccc   3480

aaggcaaaga tagcagagaa tcctgccaac ccaccagtgg gtggtaaagc aaagagcccc   3540

atgtttcctg ctctaggcga ggccagcagt gatgatgatc tctttcagtc tgctaaacca   3600

aaaccagcaa agaaaacaaa tccctttcct ctcctggaag atgaggatga cctctttaca   3660

gatcagaaag tcaagaagaa tgagacaaaa tccagtagtc agcaggatgt catattaaca   3720

acacaagata tttttgagga tgatatattt gctacggaag caattaaacc ctctcagaaa   3780

accagagaga aggagaaaac attggaatct aatttatttg atgataacat tgatatcttt   3840

gctgacttaa ctgtaaaacc aaaagaaaag tccaaaaaga aagtggaagc caagtctata   3900

tttgatgatg atatggatga catcttctcc actggtatcc aggctaagac aaccaaacca   3960

aaaagccgat ctgcacaggc cgcacctgaa ccaagatttg aacacaaggt gtccaacatc   4020

tttgatgatc ccctgaatgc ctttggaggc cagtagagca cacagggtat ccacatgtta   4080

ccctgcagct acattgttga gttagtgatg atattgtata tgctcatggt cttaactgga   4140

ttacaaaaag caaatactag aacagctagc tcatctttta cccaatgtac ttagtatttt   4200

tctgcactgg tttaatcatg cttaatacta caaaacaaaa ataaatattt cacagtggtt   4260

ggtttgtttt gtttttaaac cacagtttga tttagttagc cttgctgggg ccataatatg   4320

cttcagggtg tgtaaaagaa gaaatctctt tgtggctttc atgggcaggg aatctcagag   4380

atagcaaatg ccacctgacc agaagtcttt gttatatgga tgggaaccct aacttagggc   4440

ttgggcaggg gaaagagaaa gaagatgaga gattatactt catgagtctt agcaatatgg   4500

gagcaggttt tcactgaatt ctgagggtgc ctctgcatgt cctccaaggc aaagtttggc   4560

aaactgtggc ccccccactg tcatattttg ttaataaaat tttattggaa cacaatcaca   4620

a                                                                   4621


<210>  719
<211>  1318
<212>  PRT
<213>  Homo sapiens

<400>  719

Met Met Asn Arg Thr Thr Pro Asp Gln Glu Leu Val Pro Ala Ser Glu 
1               5                   10                  15


Pro Val Trp Glu Arg Pro Trp Ser Val Glu Glu Ile Arg Arg Ser Ser 
            20                  25                  30


Gln Ser Trp Ser Leu Ala Ala Asp Ala Gly Leu Leu Gln Phe Leu Gln 
        35                  40                  45


Glu Phe Ser Gln Gln Thr Ile Ser Arg Thr His Glu Ile Lys Lys Gln 
    50                  55                  60


Val Asp Gly Leu Ile Arg Glu Thr Lys Ala Thr Asp Cys Arg Leu His 
65                  70                  75                  80


Asn Val Phe Asn Asp Phe Leu Met Leu Ser Asn Thr Gln Phe Ile Glu 
                85                  90                  95


Asn Arg Val Tyr Asp Glu Glu Val Glu Glu Pro Val Leu Lys Ala Glu 
            100                 105                 110


Ala Glu Lys Thr Glu Gln Glu Lys Thr Arg Glu Gln Lys Glu Val Asp 
        115                 120                 125


Leu Ile Pro Lys Val Gln Glu Ala Val Asn Tyr Gly Leu Gln Val Leu 
    130                 135                 140


Asp Ser Ala Phe Glu Gln Leu Asp Ile Lys Ala Gly Asn Ser Asp Ser 
145                 150                 155                 160


Glu Glu Asp Asp Ala Asn Gly Arg Val Glu Leu Ile Leu Glu Pro Lys 
                165                 170                 175


Asp Leu Tyr Ile Asp Arg Pro Leu Pro Tyr Leu Ile Gly Ser Lys Leu 
            180                 185                 190


Phe Met Glu Gln Glu Asp Val Gly Leu Gly Glu Leu Ser Ser Glu Glu 
        195                 200                 205


Gly Ser Val Gly Ser Asp Arg Gly Ser Ile Val Asp Thr Glu Glu Glu 
    210                 215                 220


Lys Glu Glu Glu Glu Ser Asp Glu Asp Phe Ala His His Ser Asp Asn 
225                 230                 235                 240


Glu Gln Asn Gln His Thr Thr Gln Met Ser Asp Glu Glu Glu Asp Asp 
                245                 250                 255


Asp Gly Cys Asp Leu Phe Ala Asp Ser Glu Lys Glu Glu Glu Asp Ile 
            260                 265                 270


Glu Asp Ile Glu Glu Asn Thr Arg Pro Lys Arg Ser Arg Pro Thr Ser 
        275                 280                 285


Phe Ala Asp Glu Leu Ala Ala Arg Ile Lys Gly Asp Ala Met Gly Arg 
    290                 295                 300


Val Asp Glu Glu Pro Thr Thr Leu Pro Ser Gly Glu Ala Lys Pro Arg 
305                 310                 315                 320


Lys Thr Leu Lys Glu Lys Lys Glu Arg Arg Thr Pro Ser Asp Asp Glu 
                325                 330                 335


Glu Asp Asn Leu Phe Ala Pro Pro Lys Leu Thr Asp Glu Asp Phe Ser 
            340                 345                 350


Pro Phe Gly Ser Gly Gly Gly Leu Phe Ser Gly Gly Lys Gly Leu Phe 
        355                 360                 365


Asp Asp Glu Asp Glu Glu Ser Asp Leu Phe Thr Glu Ala Ser Gln Asp 
    370                 375                 380


Arg Gln Ala Gly Ala Ser Val Lys Glu Glu Ser Ser Ser Ser Lys Pro 
385                 390                 395                 400


Gly Lys Lys Ile Pro Ala Gly Ala Val Ser Val Phe Leu Gly Asp Thr 
                405                 410                 415


Asp Val Phe Gly Ala Ala Ser Val Pro Ser Leu Lys Glu Pro Gln Lys 
            420                 425                 430


Pro Glu Gln Pro Thr Pro Arg Lys Ser Pro Tyr Gly Pro Pro Pro Thr 
        435                 440                 445


Gly Leu Phe Asp Asp Asp Asp Gly Asp Asp Asp Asp Asp Phe Phe Ser 
    450                 455                 460


Ala Pro His Ser Lys Pro Ser Lys Thr Arg Lys Val Gln Ser Thr Ala 
465                 470                 475                 480


Asp Ile Phe Gly Asp Glu Glu Gly Asp Leu Phe Lys Glu Lys Ala Val 
                485                 490                 495


Ala Ser Pro Glu Ala Thr Val Ser Gln Thr Asp Glu Asn Lys Ala Arg 
            500                 505                 510


Ala Glu Lys Lys Val Thr Leu Ser Tyr Ser Lys Asn Leu Lys Pro Ser 
        515                 520                 525


Ser Glu Thr Lys Thr Gln Lys Gly Leu Phe Ser Asp Glu Glu Asp Ser 
    530                 535                 540


Glu Asp Leu Phe Ser Ser Gln Ser Ala Ser Asn Leu Lys Gly Ala Ser 
545                 550                 555                 560


Leu Leu Pro Gly Lys Leu Pro Thr Ser Val Ser Leu Phe Asp Asp Glu 
                565                 570                 575


Asp Glu Glu Asp Asn Leu Phe Gly Gly Thr Ala Ala Lys Lys Gln Thr 
            580                 585                 590


Leu Ser Leu Gln Ala Gln Arg Glu Glu Lys Ala Lys Ala Ser Glu Leu 
        595                 600                 605


Ser Lys Lys Lys Ala Ser Ala Leu Leu Phe Ser Ser Asp Glu Glu Trp 
    610                 615                 620


Asn Ile Pro Ala Ser Gln Thr His Leu Ala Ser Asp Ser Arg Ser Lys 
625                 630                 635                 640


Gly Glu Pro Arg Asp Ser Gly Thr Leu Gln Ser Gln Glu Ala Lys Ala 
                645                 650                 655


Val Lys Lys Thr Ser Leu Phe Glu Glu Asp Lys Glu Asp Asp Leu Phe 
            660                 665                 670


Ala Ile Ala Lys Asp Ser Gln Lys Lys Thr Gln Arg Val Ser Leu Leu 
        675                 680                 685


Phe Glu Asp Asp Val Asp Ser Gly Gly Ser Leu Phe Gly Ser Pro Pro 
    690                 695                 700


Thr Ser Val Pro Pro Ala Thr Lys Lys Lys Glu Thr Val Ser Glu Ala 
705                 710                 715                 720


Pro Pro Leu Leu Phe Ser Asp Glu Glu Glu Lys Glu Ala Gln Leu Gly 
                725                 730                 735


Val Lys Ser Val Asp Lys Lys Val Glu Ser Ala Lys Glu Ser Leu Lys 
            740                 745                 750


Phe Gly Arg Thr Asp Val Ala Glu Ser Glu Lys Glu Gly Leu Leu Thr 
        755                 760                 765


Arg Ser Ala Gln Glu Thr Val Lys His Ser Asp Leu Phe Ser Ser Ser 
    770                 775                 780


Ser Pro Trp Asp Lys Gly Thr Lys Pro Arg Thr Lys Thr Val Leu Ser 
785                 790                 795                 800


Leu Phe Asp Glu Glu Glu Asp Lys Met Glu Asp Gln Asn Ile Ile Gln 
                805                 810                 815


Ala Pro Gln Lys Glu Val Gly Lys Gly Cys Asp Pro Asp Ala His Pro 
            820                 825                 830


Lys Ser Thr Gly Val Phe Gln Asp Glu Glu Leu Leu Phe Ser His Lys 
        835                 840                 845


Leu Gln Lys Asp Asn Asp Pro Asp Val Asp Leu Phe Ala Gly Thr Lys 
    850                 855                 860


Lys Thr Lys Leu Leu Glu Pro Ser Val Gly Ser Leu Phe Gly Asp Asp 
865                 870                 875                 880


Glu Asp Asp Asp Leu Phe Ser Ser Ala Lys Ser Gln Pro Leu Val Gln 
                885                 890                 895


Glu Lys Lys Arg Val Val Lys Lys Asp His Ser Val Asn Ser Phe Lys 
            900                 905                 910


Asn Gln Lys His Pro Glu Ser Ile Gln Gly Ser Lys Glu Lys Gly Ile 
        915                 920                 925


Trp Lys Pro Glu Thr Pro Gln Ala Asn Leu Ala Ile Asn Pro Ala Ala 
    930                 935                 940


Leu Leu Pro Thr Ala Ala Ser Gln Ile Ser Glu Val Lys Pro Val Leu 
945                 950                 955                 960


Pro Glu Leu Ala Phe Pro Ser Ser Glu His Arg Arg Ser His Gly Leu 
                965                 970                 975


Glu Ser Val Pro Val Leu Pro Gly Ser Gly Glu Ala Gly Val Ser Phe 
            980                 985                 990


Asp Leu Pro Ala Gln Ala Asp Thr Leu His Ser Ala Asn Lys Ser Arg 
        995                 1000                1005


Val Lys Met Arg Gly Lys Arg Arg Pro Gln Thr Arg Ala Ala Arg Arg 
    1010                1015                1020


Leu Ala Ala Gln Glu Ser Ser Glu Ala Glu Asp Met Ser Val Pro Arg 
1025                1030                1035                1040


Gly Pro Ile Ala Gln Trp Ala Asp Gly Ala Ile Ser Pro Asn Gly His 
                1045                1050                1055


Arg Pro Gln Leu Arg Ala Ala Ser Gly Glu Asp Ser Thr Glu Glu Ala 
            1060                1065                1070


Leu Ala Ala Ala Ala Ala Pro Trp Glu Gly Gly Pro Val Pro Gly Val 
        1075                1080                1085


Asp Thr Ser Pro Phe Ala Lys Ser Leu Gly His Ser Arg Gly Glu Ala 
    1090                1095                1100


Asp Leu Phe Asp Ser Gly Asp Ile Phe Ser Thr Gly Thr Gly Ser Gln 
1105                1110                1115                1120


Ser Val Glu Arg Thr Lys Pro Lys Ala Lys Ile Ala Glu Asn Pro Ala 
                1125                1130                1135


Asn Pro Pro Val Gly Gly Lys Ala Lys Ser Pro Met Phe Pro Ala Leu 
            1140                1145                1150


Gly Glu Ala Ser Ser Asp Asp Asp Leu Phe Gln Ser Ala Lys Pro Lys 
        1155                1160                1165


Pro Ala Lys Lys Thr Asn Pro Phe Pro Leu Leu Glu Asp Glu Asp Asp 
    1170                1175                1180


Leu Phe Thr Asp Gln Lys Val Lys Lys Asn Glu Thr Lys Ser Ser Ser 
1185                1190                1195                1200


Gln Gln Asp Val Ile Leu Thr Thr Gln Asp Ile Phe Glu Asp Asp Ile 
                1205                1210                1215


Phe Ala Thr Glu Ala Ile Lys Pro Ser Gln Lys Thr Arg Glu Lys Glu 
            1220                1225                1230


Lys Thr Leu Glu Ser Asn Leu Phe Asp Asp Asn Ile Asp Ile Phe Ala 
        1235                1240                1245


Asp Leu Thr Val Lys Pro Lys Glu Lys Ser Lys Lys Lys Val Glu Ala 
    1250                1255                1260


Lys Ser Ile Phe Asp Asp Asp Met Asp Asp Ile Phe Ser Thr Gly Ile 
1265                1270                1275                1280


Gln Ala Lys Thr Thr Lys Pro Lys Ser Arg Ser Ala Gln Ala Ala Pro 
                1285                1290                1295


Glu Pro Arg Phe Glu His Lys Val Ser Asn Ile Phe Asp Asp Pro Leu 
            1300                1305                1310


Asn Ala Phe Gly Gly Gln 
        1315


<210>  720
<211>  322
<212>  DNA
<213>  Homo sapiens

<400>  720
tcatcctgga ctcgggggca gcgggcctgc tctgagccct caccctggac ttgtctcctc     60

tgttcagttc atgccatgga ggaagtggtg aaggaggtgg tgggacatgc caaggagact    120

ggagagaaag ccattgccga agccataaag aaagcccaag agtcagggga caaaaagatg    180

aaggaagtca ctgagacagt gaccaacaca gtcacaaatg ccatcaccca tgcagcagag    240

agtctgggca aacttggaca gtgaatgcac ctgctaccat ggcccaccct tcccaagtct    300

caataaaaag ccatgaaata tg                                             322


<210>  721
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  721

Met Glu Glu Val Val Lys Glu Val Val Gly His Ala Lys Glu Thr Gly 
1               5                   10                  15


Glu Lys Ala Ile Ala Glu Ala Ile Lys Lys Ala Gln Glu Ser Gly Asp 
            20                  25                  30


Lys Lys Met Lys Glu Val Thr Glu Thr Val Thr Asn Thr Val Thr Asn 
        35                  40                  45


Ala Ile Thr His Ala Ala Glu Ser Leu Gly Lys Leu Gly Gln 
    50                  55                  60


<210>  722
<211>  2431
<212>  DNA
<213>  Homo sapiens

<400>  722
gtgggcaggc gaggagcggg aagaccatct ctgcaagtgc agcatagcct cggcctagga     60

cagcgggagt gcgtggccaa agctgtgagc agaggcacag gtggtggcag acagtagagg    120

cgccccatgg ggaacatact gacctgtcgt gtgcacccta gcgtcagcct cgagtttgac    180

cagcagcagg ggtcggtgtg tccctctgaa tctgagatct atgaggcagg agctggggac    240

aggatggcag gagcgcccat ggctgctgct gtacagcctg ctgaggtgac tgttgaagtt    300

ggtgaggacc tccacatgca ccacgttcgt gaccgggaga tgcctgaagc tttggagttt    360

aacccttctg ccaatccaga ggcaagcaca atattccaga ggaactctca aacagatgtt    420

gtagaaataa gaagaagcaa ctgtacaaac catgtatcta ctgtgcgttt cagtcaacaa    480

tacagcttgt gttcgacaat attccttgat gacagcacag ccatccagca ttatcttaca    540

atgacaataa tatctgtgac cttggagata cctcatcata tcacacaaag agatgcagat    600

agatctttga gcatacctga tgaacagtta cactcatttg cggtttccac cgtgcacatt    660

atgaagaaaa gaaatggagg tgggagttta aataactatt cctcctccat tccatcgact    720

cccagcacca gccaggagga ccctcagttc agtgttcctc ccactgccaa cacacccacc    780

cccgtttgca agcggtccat gcgctggtcc aacctgttta catctgagaa agggagtgac    840

ccagacaaag agaggaaagc cccggagaat catgctgaca ccatcgggag cggcagagcc    900

atccccatta aacagggcat gctcttaaag cgaagtggga aatggctgaa gacatggaaa    960

aagaaatacg tcaccctgtg ttccaatggc gtgctcacct attattcaag cttaggtgat   1020

tatatgaaga atattcataa aaaagagatt gaccttcaga catctaccat caaagtccca   1080

ggaaagtggc catccctagc cacatcggcc tgcacaccca tctccacctc taaaagcaat   1140

ggcctatcca aggacatgga caccgggctg ggtgactcca tatgcttcag ccccagtatc   1200

tccagcacca ccagccccaa gctcaacccg cccccctctc ctcatgccaa taaaaagaaa   1260

cacctaaaga agaaaagcac caacaacttt atgattgtgt ctgccactgg ccaaacgtgg   1320

cactttgaag ccacgacgta tgaggagcgg gatgcctggg tccaagccat ccagagccag   1380

atcctggcca gcctgcagtc atgcgagagc agtaaaagca agtcccagct gaccagccag   1440

agcaaggcca tggccctgca gtcgatccaa aacatgcgtg ggaacgccca ctgtgtggac   1500

tgtgagaccc agaatcctaa gtgggccagt ttgaacttgg gagtcctcat gtgtattgaa   1560

tgctcaggaa tccaccgcag tcttggcacc cgcctttccc gtgtgcgatc tctggagctg   1620

gatgactggc cagttgagct caggaaggtt atgtcatcta ttggcaatga cctagccaac   1680

agcatctggg aagggagcag ccaggggcag acaaaaccct cagaaaagtc cacgagggaa   1740

gagaaggaac ggtggatccg ttccaaatat gaggagaagc tctttctggc cccactaccc   1800

tgcactgagc tgtccctggg ccagcagctg ctgcgggcca ccgctgatga ggacctgcag   1860

acagccatcc tgctgctggc acatggctcc cgtgaggagg tgaacgagac ctgtggggag   1920

ggagacggct gcacggcgct ccatctggcc tgccgcaagg ggaatgtggt cctggcgcag   1980

ctcctgatct ggtacggggt ggacgtcatg gcccgagatg cccacgggaa cacagcgctg   2040

acctacgccc ggcaggcctc cagccaggag tgcatcaacg tgcttctgca gtacggctgc   2100

cccgacaagt gtgtgtagta tctgttttat ttgactgcag tctccttggt gcaaaaacaa   2160

aatgggaaaa ataaggataa ctcagaattt caaaaggaaa tcacaaattc agctaataat   2220

agcattttca gtacttttcg taaactaagt aaatacacaa aatgttgatt tttctgacca   2280

taagacgtat tttatgtcct tttgccaagg tggatttgtt agtctcaggc cctcctggcc   2340

acattgccca agtcacacag gcttctgtat tatgtattta gataaaatgt gtgaaaatat   2400

atttgaaata aagttcataa atatgcattg a                                  2431


<210>  723
<211>  663
<212>  PRT
<213>  Homo sapiens

<400>  723

Met Gly Asn Ile Leu Thr Cys Arg Val His Pro Ser Val Ser Leu Glu 
1               5                   10                  15


Phe Asp Gln Gln Gln Gly Ser Val Cys Pro Ser Glu Ser Glu Ile Tyr 
            20                  25                  30


Glu Ala Gly Ala Gly Asp Arg Met Ala Gly Ala Pro Met Ala Ala Ala 
        35                  40                  45


Val Gln Pro Ala Glu Val Thr Val Glu Val Gly Glu Asp Leu His Met 
    50                  55                  60


His His Val Arg Asp Arg Glu Met Pro Glu Ala Leu Glu Phe Asn Pro 
65                  70                  75                  80


Ser Ala Asn Pro Glu Ala Ser Thr Ile Phe Gln Arg Asn Ser Gln Thr 
                85                  90                  95


Asp Val Val Glu Ile Arg Arg Ser Asn Cys Thr Asn His Val Ser Thr 
            100                 105                 110


Val Arg Phe Ser Gln Gln Tyr Ser Leu Cys Ser Thr Ile Phe Leu Asp 
        115                 120                 125


Asp Ser Thr Ala Ile Gln His Tyr Leu Thr Met Thr Ile Ile Ser Val 
    130                 135                 140


Thr Leu Glu Ile Pro His His Ile Thr Gln Arg Asp Ala Asp Arg Ser 
145                 150                 155                 160


Leu Ser Ile Pro Asp Glu Gln Leu His Ser Phe Ala Val Ser Thr Val 
                165                 170                 175


His Ile Met Lys Lys Arg Asn Gly Gly Gly Ser Leu Asn Asn Tyr Ser 
            180                 185                 190


Ser Ser Ile Pro Ser Thr Pro Ser Thr Ser Gln Glu Asp Pro Gln Phe 
        195                 200                 205


Ser Val Pro Pro Thr Ala Asn Thr Pro Thr Pro Val Cys Lys Arg Ser 
    210                 215                 220


Met Arg Trp Ser Asn Leu Phe Thr Ser Glu Lys Gly Ser Asp Pro Asp 
225                 230                 235                 240


Lys Glu Arg Lys Ala Pro Glu Asn His Ala Asp Thr Ile Gly Ser Gly 
                245                 250                 255


Arg Ala Ile Pro Ile Lys Gln Gly Met Leu Leu Lys Arg Ser Gly Lys 
            260                 265                 270


Trp Leu Lys Thr Trp Lys Lys Lys Tyr Val Thr Leu Cys Ser Asn Gly 
        275                 280                 285


Val Leu Thr Tyr Tyr Ser Ser Leu Gly Asp Tyr Met Lys Asn Ile His 
    290                 295                 300


Lys Lys Glu Ile Asp Leu Gln Thr Ser Thr Ile Lys Val Pro Gly Lys 
305                 310                 315                 320


Trp Pro Ser Leu Ala Thr Ser Ala Cys Thr Pro Ile Ser Thr Ser Lys 
                325                 330                 335


Ser Asn Gly Leu Ser Lys Asp Met Asp Thr Gly Leu Gly Asp Ser Ile 
            340                 345                 350


Cys Phe Ser Pro Ser Ile Ser Ser Thr Thr Ser Pro Lys Leu Asn Pro 
        355                 360                 365


Pro Pro Ser Pro His Ala Asn Lys Lys Lys His Leu Lys Lys Lys Ser 
    370                 375                 380


Thr Asn Asn Phe Met Ile Val Ser Ala Thr Gly Gln Thr Trp His Phe 
385                 390                 395                 400


Glu Ala Thr Thr Tyr Glu Glu Arg Asp Ala Trp Val Gln Ala Ile Gln 
                405                 410                 415


Ser Gln Ile Leu Ala Ser Leu Gln Ser Cys Glu Ser Ser Lys Ser Lys 
            420                 425                 430


Ser Gln Leu Thr Ser Gln Ser Lys Ala Met Ala Leu Gln Ser Ile Gln 
        435                 440                 445


Asn Met Arg Gly Asn Ala His Cys Val Asp Cys Glu Thr Gln Asn Pro 
    450                 455                 460


Lys Trp Ala Ser Leu Asn Leu Gly Val Leu Met Cys Ile Glu Cys Ser 
465                 470                 475                 480


Gly Ile His Arg Ser Leu Gly Thr Arg Leu Ser Arg Val Arg Ser Leu 
                485                 490                 495


Glu Leu Asp Asp Trp Pro Val Glu Leu Arg Lys Val Met Ser Ser Ile 
            500                 505                 510


Gly Asn Asp Leu Ala Asn Ser Ile Trp Glu Gly Ser Ser Gln Gly Gln 
        515                 520                 525


Thr Lys Pro Ser Glu Lys Ser Thr Arg Glu Glu Lys Glu Arg Trp Ile 
    530                 535                 540


Arg Ser Lys Tyr Glu Glu Lys Leu Phe Leu Ala Pro Leu Pro Cys Thr 
545                 550                 555                 560


Glu Leu Ser Leu Gly Gln Gln Leu Leu Arg Ala Thr Ala Asp Glu Asp 
                565                 570                 575


Leu Gln Thr Ala Ile Leu Leu Leu Ala His Gly Ser Arg Glu Glu Val 
            580                 585                 590


Asn Glu Thr Cys Gly Glu Gly Asp Gly Cys Thr Ala Leu His Leu Ala 
        595                 600                 605


Cys Arg Lys Gly Asn Val Val Leu Ala Gln Leu Leu Ile Trp Tyr Gly 
    610                 615                 620


Val Asp Val Met Ala Arg Asp Ala His Gly Asn Thr Ala Leu Thr Tyr 
625                 630                 635                 640


Ala Arg Gln Ala Ser Ser Gln Glu Cys Ile Asn Val Leu Leu Gln Tyr 
                645                 650                 655


Gly Cys Pro Asp Lys Cys Val 
            660


<210>  724
<211>  2478
<212>  DNA
<213>  Homo sapiens

<400>  724
tggacccaac tggcgaggct gctggggttg cagcgggaca gttggggcgg ccccgcaggc     60

ccaggtgaac aaaaattgtt tgctggcccc caggatacta actagacctt tggcctgact    120

cacaggacac taaggctcct tttctgaaga agccttttac cagtctcatt taggggatgg    180

gaacaacatg tcttcaccta gggactttag agcagagcct gtaaacgatt atgagggaaa    240

tgactctgaa gcagaagact tgaatttcag ggagactttg ccttcatcaa gtcaggaaaa    300

cacacctaga tcaaaggttt ttgaaaataa agttaattca gagaaggtaa aactttctct    360

tcggaatttc ccacataatg attatgagga tgtttttgaa gagccttcag aaagtggcag    420

tgatcccagc atgtggacag ccagaggccc cttcagaaga gacaggtgga gcagtgagga    480

tgaggaggct gcagggccat cacaggctct ctcccctcta ctttctgata cgcgcaaaat    540

tgtttctgaa ggagaactag atcagttggc tcagattcgg ccattaatat tcaattttca    600

tgagcagaca gccatcaagg attgtttgaa aatccttgag gaaaaaacag cagcgtatga    660

tatcatgcag gaatttatgg ctttagaact taagaatctg cctggtgagt tcaactctgg    720

gaatcaacca agcaacagag aaaaaaacag ataccgagat attcttccat ttcaacatca    780

tggatatagt ggcccaaatg agagaacaac gttctggcat ggttcaaacg aaggagcagt    840

atcacttttg ttacgatatt gtgcttgaag ttcttcggaa acttctgact ttggattaag    900

aaagacttct gttgcctctc acttgaaatt accaagtggg tttgcacctc ctcataaaga    960

acatgtttgc actgtgctga agggctttgc tatgcataca atctgctttc ttggtttatc   1020

agtttatttt ctttctaaaa gctccctgaa gggcaatatc atttggcttg gggtgatcag   1080

tgtttactta ttgatcttgc tagacaatat caaaataact tcccacattt tccagtgaaa   1140

cagatgttac ataaaacgat tgcagcttgg ctatttggtt gaagggatta cagagcccaa   1200

taaaggattt aaaatatatt cattaagatt ttatttggaa aggtggctgg agagagctga   1260

ggatttccag gactttgtaa gttcttattc tgggagaaca taaggccaat aatcatgacc   1320

tcttccaggc atttttaaga cagatgtcta ttcatgttct ttagctagag cctgtacttt   1380

ttgctggcat ttgaataacc cagtttaaaa agagtccagt tagggtggac taactttgga   1440

cacaaattgg cttccatttc ctacattttc atactgctgc cttcctacag ctgctagacc   1500

aagacctgtt ggtctgggaa gcatttcatg gatagggaga gctcctctcg gtgaacagtc   1560

caaaactaaa atagatgttt atatagaaag cccaagagga gatttttgcc atgcctgagt   1620

tctttcctat cccaccctaa cacttaacat attacttagt ctgctttgtt aaaagcaagt   1680

attaccttta acttgcctct tactctttgc cctttagcta actaataaag tttgatatag   1740

gcattattat ataattctga gtcattcatg gtatatctca tgtttgatgt atttttcaaa   1800

ctaagatcta tgatagtttt ttttccagag ttccattaaa tcatttattt cctttacttt   1860

ctcacctctg ttgaaacatt tagaaactgg atttgggaac ccaattttgg aaaaccagat   1920

tcatagtcat gaaaatggaa acttccatat tctgtttttg aaaagatgtg gccattatta   1980

cagtaatttt attataggac tttgcctcgt acaattaata gtgatatttt ggacaaggag   2040

ttctggtgac aagctatacc taattataag ctataaaaca atagatatga gtgtttgtac   2100

agtttaactc aatggagatc agaatattct atgtattgag aaaatgttta atatcaatct   2160

ataaatcttg aatttctaag aggcttattt tgttcttttg gctgaatgag tatatttgaa   2220

ttggttgaat aattaataat tctcattgta aaaataatta tatgccaaaa atatatttga   2280

tgttaaatca aatagatgat tctgtttaca ttgttcatat gaataataat ctgtgttaat   2340

ttcattttga taattggcct ttaatatttg tatctctaat tttattttct ctctgttact   2400

gtaaaataat agctataatg tataacaatt ttcttcagaa gaattctatg ctattattaa   2460

aataaaatat ttactgtg                                                 2478


<210>  725
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  725

Met Ser Ser Pro Arg Asp Phe Arg Ala Glu Pro Val Asn Asp Tyr Glu 
1               5                   10                  15


Gly Asn Asp Ser Glu Ala Glu Asp Leu Asn Phe Arg Glu Thr Leu Pro 
            20                  25                  30


Ser Ser Ser Gln Glu Asn Thr Pro Arg Ser Lys Val Phe Glu Asn Lys 
        35                  40                  45


Val Asn Ser Glu Lys Val Lys Leu Ser Leu Arg Asn Phe Pro His Asn 
    50                  55                  60


Asp Tyr Glu Asp Val Phe Glu Glu Pro Ser Glu Ser Gly Ser Asp Pro 
65                  70                  75                  80


Ser Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser 
                85                  90                  95


Glu Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu 
            100                 105                 110


Ser Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala 
        115                 120                 125


Gln Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys 
    130                 135                 140


Asp Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met 
145                 150                 155                 160


Gln Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro Gly Glu Phe Asn 
                165                 170                 175


Ser Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg Tyr Arg Asp Ile 
            180                 185                 190


Leu Pro Phe Gln His His Gly Tyr Ser Gly Pro Asn Glu Arg Thr Thr 
        195                 200                 205


Phe Trp His Gly Ser Asn Glu Gly Ala Val Ser Leu Leu Leu Arg Tyr 
    210                 215                 220


Cys Ala 
225


<210>  726
<211>  2965
<212>  DNA
<213>  Homo sapiens

<400>  726
gtgaacaaaa attgtttgct ggcccccagg atactaacta gacctttggc ctgactcaca     60

ggacactaag gctccttttc tgaagaagcc ttttaccagt ctcatttagg ggatgggaac    120

aacatgtctt cacctaggga ctttagagca gagcctgtaa acgattatga gggaaatgac    180

tctgaagcag aagacttgaa tttcagggag actttgcctt catcaagtca ggaaaacaca    240

cctagatcaa aggtttttga aaataaagtt aattcagaga aggtaaaact ttctcttcgg    300

aatttcccac ataatgatta tgaggatgtt tttgaagagc cttcagaaag tggcagtgat    360

cccagcatgt ggacagccag aggccccttc agaagagaca ggtggagcag tgaggatgag    420

gaggctgcag ggccatcaca ggctctctcc cctctacttt ctgatacgcg caaaattgtt    480

tctgaaggag aactagatca gttggctcag attcggccat taatattcaa ttttcatgag    540

cagacagcca tcaaggattg tttgaaaatc cttgaggaaa aaacagcagc gtatgatatc    600

atgcaggaat ttatggcttt agaacttaag aatctgcctg gtgagttcaa ctctgggaat    660

caaccaagca acagagaaaa aaacagatac cgagatattc ttccatatga ttcaacacgc    720

gttcctcttg gaaaaagcaa ggactacatc aatgctagtt atattagaat agtcaattgt    780

ggagaagagt atttttatat cgctactcaa ggaccactgc tgagcaccat agatgacttt    840

tggcaaatgg tgttggaaaa taattcaaat gttattgcca tgataaccag agagatagaa    900

ggtggaatta tcaaatgcta ccattactgg cccatttctc tgaagaagcc attggaattg    960

aaacacttcc gtgtattcct ggagaactac cagatacttc aatatttcat cattcgaatg   1020

tttcaagttg tggagaagtc cacgggaact agtcactctg taaaacagtt gcagttcacc   1080

aagtggccag accatggcac tcctgcctca gcagatagct tcataaaata tattcgttat   1140

gcaaggaaga gccaccttac aggacccatg gttgttcact gcagtgccgg cataggccgg   1200

acaggggtgt tcctatgtgt ggatgtcgtg ttctgtgcca tcgtaaagaa ctgttcattc   1260

aacatcatgg atatagtggc ccaaatgaga gaacaacgtt ctggcatggt tcaaacgaag   1320

gagcagtatc acttttgtta cgatattgtg cttgaagttc ttcggaaact tctgactttg   1380

gattaagaaa gacttctgtt gcctctcact tgaaattacc aagtgggttt gcacctcctc   1440

ataaagaaca tgtttgcact gtgctgaagg gctttgctat gcatacaatc tgctttcttg   1500

gtttatcagt ttattttctt tctaaaagct ccctgaaggg caatatcatt tggcttgggg   1560

tgatcagtgt ttacttattg atcttgctag acaatatcaa aataacttcc cacattttcc   1620

agtgaaacag atgttacata aaacgattgc agcttggcta tttggttgaa gggattacag   1680

agcccaataa aggatttaaa atatattcat taagatttta tttggaaagg tggctggaga   1740

gagctgagga tttccaggac tttgtaagtt cttattctgg gagaacataa ggccaataat   1800

catgacctct tccaggcatt tttaagacag atgtctattc atgttcttta gctagagcct   1860

gtactttttg ctggcatttg aataacccag tttaaaaaga gtccagttag ggtggactaa   1920

ctttggacac aaattggctt ccatttccta cattttcata ctgctgcctt cctacagctg   1980

ctagaccaag acctgttggt ctgggaagca tttcatggat agggagagct cctctcggtg   2040

aacagtccaa aactaaaata gatgtttata tagaaagccc aagaggagat ttttgccatg   2100

cctgagttct ttcctatccc accctaacac ttaacatatt acttagtctg ctttgttaaa   2160

agcaagtatt acctttaact tgcctcttac tctttgccct ttagctaact aataaagttt   2220

gatataggca ttattatata attctgagtc attcatggta tatctcatgt ttgatgtatt   2280

tttcaaacta agatctatga tagttttttt tccagagttc cattaaatca tttatttcct   2340

ttactttctc acctctgttg aaacatttag aaactggatt tgggaaccca attttggaaa   2400

accagattca tagtcatgaa aatggaaact tccatattct gtttttgaaa agatgtggcc   2460

attattacag taattttatt ataggacttt gcctcgtaca attaatagtg atattttgga   2520

caaggagttc tggtgacaag ctatacctaa ttataagcta taaaacaata gatatgagtg   2580

tttgtacagt ttaactcaat ggagatcaga atattctatg tattgagaaa atgtttaata   2640

tcaatctata aatcttgaat ttctaagagg cttattttgt tcttttggct gaatgagtat   2700

atttgaattg gttgaataat taataattct cattgtaaaa ataattatat gccaaaaata   2760

tatttgatgt taaatcaaat agatgattct gtttacattg ttcatatgaa taataatctg   2820

tgttaatttc attttgataa ttggccttta atatttgtat ctctaatttt attttctctc   2880

tgttactgta aaataatagc tataatgtat aacaattttc ttcagaagaa ttctatgcta   2940

ttattaaaat aaaatattta ctgtg                                         2965


<210>  727
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  727

Met Ser Ser Pro Arg Asp Phe Arg Ala Glu Pro Val Asn Asp Tyr Glu 
1               5                   10                  15


Gly Asn Asp Ser Glu Ala Glu Asp Leu Asn Phe Arg Glu Thr Leu Pro 
            20                  25                  30


Ser Ser Ser Gln Glu Asn Thr Pro Arg Ser Lys Val Phe Glu Asn Lys 
        35                  40                  45


Val Asn Ser Glu Lys Val Lys Leu Ser Leu Arg Asn Phe Pro His Asn 
    50                  55                  60


Asp Tyr Glu Asp Val Phe Glu Glu Pro Ser Glu Ser Gly Ser Asp Pro 
65                  70                  75                  80


Ser Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser 
                85                  90                  95


Glu Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu 
            100                 105                 110


Ser Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala 
        115                 120                 125


Gln Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys 
    130                 135                 140


Asp Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met 
145                 150                 155                 160


Gln Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro Gly Glu Phe Asn 
                165                 170                 175


Ser Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg Tyr Arg Asp Ile 
            180                 185                 190


Leu Pro Tyr Asp Ser Thr Arg Val Pro Leu Gly Lys Ser Lys Asp Tyr 
        195                 200                 205


Ile Asn Ala Ser Tyr Ile Arg Ile Val Asn Cys Gly Glu Glu Tyr Phe 
    210                 215                 220


Tyr Ile Ala Thr Gln Gly Pro Leu Leu Ser Thr Ile Asp Asp Phe Trp 
225                 230                 235                 240


Gln Met Val Leu Glu Asn Asn Ser Asn Val Ile Ala Met Ile Thr Arg 
                245                 250                 255


Glu Ile Glu Gly Gly Ile Ile Lys Cys Tyr His Tyr Trp Pro Ile Ser 
            260                 265                 270


Leu Lys Lys Pro Leu Glu Leu Lys His Phe Arg Val Phe Leu Glu Asn 
        275                 280                 285


Tyr Gln Ile Leu Gln Tyr Phe Ile Ile Arg Met Phe Gln Val Val Glu 
    290                 295                 300


Lys Ser Thr Gly Thr Ser His Ser Val Lys Gln Leu Gln Phe Thr Lys 
305                 310                 315                 320


Trp Pro Asp His Gly Thr Pro Ala Ser Ala Asp Ser Phe Ile Lys Tyr 
                325                 330                 335


Ile Arg Tyr Ala Arg Lys Ser His Leu Thr Gly Pro Met Val Val His 
            340                 345                 350


Cys Ser Ala Gly Ile Gly Arg Thr Gly Val Phe Leu Cys Val Asp Val 
        355                 360                 365


Val Phe Cys Ala Ile Val Lys Asn Cys Ser Phe Asn Ile Met Asp Ile 
    370                 375                 380


Val Ala Gln Met Arg Glu Gln Arg Ser Gly Met Val Gln Thr Lys Glu 
385                 390                 395                 400


Gln Tyr His Phe Cys Tyr Asp Ile Val Leu Glu Val Leu Arg Lys Leu 
                405                 410                 415


Leu Thr Leu Asp 
            420


<210>  728
<211>  2870
<212>  DNA
<213>  Homo sapiens

<400>  728
ctgtggctct gtggtagggg aatgccacca actccctgag gagcagccgt gtggtatgat     60

tgtaaacgat tatgagggaa atgactctga agcagaagac ttgaatttca gggagacttt    120

gccttcatca agtcaggaaa acacacctag atcaaaggtt tttgaaaata aagttaattc    180

agagaaggta aaactttctc ttcggaattt cccacataat gattatgagg atgtttttga    240

agagccttca gaaagtggca gtgatcccag catgtggaca gccagaggcc ccttcagaag    300

agacaggtgg agcagtgagg atgaggaggc tgcagggcca tcacaggctc tctcccctct    360

actttctgat acgcgcaaaa ttgtttctga aggagaacta gatcagttgg ctcagattcg    420

gccattaata ttcaattttc atgagcagac agccatcaag gattgtttga aaatccttga    480

ggaaaaaaca gcagcgtatg atatcatgca ggaatttatg gctttagaac ttaagaatct    540

gcctggtgag ttcaactctg ggaatcaacc aagcaacaga gaaaaaaaca gataccgaga    600

tattcttcca tatgattcaa cacgcgttcc tcttggaaaa agcaaggact acatcaatgc    660

tagttatatt agaatagtca attgtggaga agagtatttt tatatcgcta ctcaaggacc    720

actgctgagc accatagatg acttttggca aatggtgttg gaaaataatt caaatgttat    780

tgccatgata accagagaga tagaaggtgg aattatcaaa tgctaccatt actggcccat    840

ttctctgaag aagccattgg aattgaaaca cttccgtgta ttcctggaga actaccagat    900

acttcaatat ttcatcattc gaatgtttca agttgtggag aagtccacgg gaactagtca    960

ctctgtaaaa cagttgcagt tcaccaagtg gccagaccat ggcactcctg cctcagcaga   1020

tagcttcata aaatatattc gttatgcaag gaagagccac cttacaggac ccatggttgt   1080

tcactgcagt gccggcatag gccggacagg ggtgttccta tgtgtggatg tcgtgttctg   1140

tgccatcgta aagaactgtt cattcaacat catggatata gtggcccaaa tgagagaaca   1200

acgttctggc atggttcaaa cgaaggagca gtatcacttt tgttacgata ttgtgcttga   1260

agttcttcgg aaacttctga ctttggatta agaaagactt ctgttgcctc tcacttgaaa   1320

ttaccaagtg ggtttgcacc tcctcataaa gaacatgttt gcactgtgct gaagggcttt   1380

gctatgcata caatctgctt tcttggttta tcagtttatt ttctttctaa aagctccctg   1440

aagggcaata tcatttggct tggggtgatc agtgtttact tattgatctt gctagacaat   1500

atcaaaataa cttcccacat tttccagtga aacagatgtt acataaaacg attgcagctt   1560

ggctatttgg ttgaagggat tacagagccc aataaaggat ttaaaatata ttcattaaga   1620

ttttatttgg aaaggtggct ggagagagct gaggatttcc aggactttgt aagttcttat   1680

tctgggagaa cataaggcca ataatcatga cctcttccag gcatttttaa gacagatgtc   1740

tattcatgtt ctttagctag agcctgtact ttttgctggc atttgaataa cccagtttaa   1800

aaagagtcca gttagggtgg actaactttg gacacaaatt ggcttccatt tcctacattt   1860

tcatactgct gccttcctac agctgctaga ccaagacctg ttggtctggg aagcatttca   1920

tggataggga gagctcctct cggtgaacag tccaaaacta aaatagatgt ttatatagaa   1980

agcccaagag gagatttttg ccatgcctga gttctttcct atcccaccct aacacttaac   2040

atattactta gtctgctttg ttaaaagcaa gtattacctt taacttgcct cttactcttt   2100

gccctttagc taactaataa agtttgatat aggcattatt atataattct gagtcattca   2160

tggtatatct catgtttgat gtatttttca aactaagatc tatgatagtt ttttttccag   2220

agttccatta aatcatttat ttcctttact ttctcacctc tgttgaaaca tttagaaact   2280

ggatttggga acccaatttt ggaaaaccag attcatagtc atgaaaatgg aaacttccat   2340

attctgtttt tgaaaagatg tggccattat tacagtaatt ttattatagg actttgcctc   2400

gtacaattaa tagtgatatt ttggacaagg agttctggtg acaagctata cctaattata   2460

agctataaaa caatagatat gagtgtttgt acagtttaac tcaatggaga tcagaatatt   2520

ctatgtattg agaaaatgtt taatatcaat ctataaatct tgaatttcta agaggcttat   2580

tttgttcttt tggctgaatg agtatatttg aattggttga ataattaata attctcattg   2640

taaaaataat tatatgccaa aaatatattt gatgttaaat caaatagatg attctgttta   2700

cattgttcat atgaataata atctgtgtta atttcatttt gataattggc ctttaatatt   2760

tgtatctcta attttatttt ctctctgtta ctgtaaaata atagctataa tgtataacaa   2820

ttttcttcag aagaattcta tgctattatt aaaataaaat atttactgtg              2870


<210>  729
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  729

Met Ile Val Asn Asp Tyr Glu Gly Asn Asp Ser Glu Ala Glu Asp Leu 
1               5                   10                  15


Asn Phe Arg Glu Thr Leu Pro Ser Ser Ser Gln Glu Asn Thr Pro Arg 
            20                  25                  30


Ser Lys Val Phe Glu Asn Lys Val Asn Ser Glu Lys Val Lys Leu Ser 
        35                  40                  45


Leu Arg Asn Phe Pro His Asn Asp Tyr Glu Asp Val Phe Glu Glu Pro 
    50                  55                  60


Ser Glu Ser Gly Ser Asp Pro Ser Met Trp Thr Ala Arg Gly Pro Phe 
65                  70                  75                  80


Arg Arg Asp Arg Trp Ser Ser Glu Asp Glu Glu Ala Ala Gly Pro Ser 
                85                  90                  95


Gln Ala Leu Ser Pro Leu Leu Ser Asp Thr Arg Lys Ile Val Ser Glu 
            100                 105                 110


Gly Glu Leu Asp Gln Leu Ala Gln Ile Arg Pro Leu Ile Phe Asn Phe 
        115                 120                 125


His Glu Gln Thr Ala Ile Lys Asp Cys Leu Lys Ile Leu Glu Glu Lys 
    130                 135                 140


Thr Ala Ala Tyr Asp Ile Met Gln Glu Phe Met Ala Leu Glu Leu Lys 
145                 150                 155                 160


Asn Leu Pro Gly Glu Phe Asn Ser Gly Asn Gln Pro Ser Asn Arg Glu 
                165                 170                 175


Lys Asn Arg Tyr Arg Asp Ile Leu Pro Tyr Asp Ser Thr Arg Val Pro 
            180                 185                 190


Leu Gly Lys Ser Lys Asp Tyr Ile Asn Ala Ser Tyr Ile Arg Ile Val 
        195                 200                 205


Asn Cys Gly Glu Glu Tyr Phe Tyr Ile Ala Thr Gln Gly Pro Leu Leu 
    210                 215                 220


Ser Thr Ile Asp Asp Phe Trp Gln Met Val Leu Glu Asn Asn Ser Asn 
225                 230                 235                 240


Val Ile Ala Met Ile Thr Arg Glu Ile Glu Gly Gly Ile Ile Lys Cys 
                245                 250                 255


Tyr His Tyr Trp Pro Ile Ser Leu Lys Lys Pro Leu Glu Leu Lys His 
            260                 265                 270


Phe Arg Val Phe Leu Glu Asn Tyr Gln Ile Leu Gln Tyr Phe Ile Ile 
        275                 280                 285


Arg Met Phe Gln Val Val Glu Lys Ser Thr Gly Thr Ser His Ser Val 
    290                 295                 300


Lys Gln Leu Gln Phe Thr Lys Trp Pro Asp His Gly Thr Pro Ala Ser 
305                 310                 315                 320


Ala Asp Ser Phe Ile Lys Tyr Ile Arg Tyr Ala Arg Lys Ser His Leu 
                325                 330                 335


Thr Gly Pro Met Val Val His Cys Ser Ala Gly Ile Gly Arg Thr Gly 
            340                 345                 350


Val Phe Leu Cys Val Asp Val Val Phe Cys Ala Ile Val Lys Asn Cys 
        355                 360                 365


Ser Phe Asn Ile Met Asp Ile Val Ala Gln Met Arg Glu Gln Arg Ser 
    370                 375                 380


Gly Met Val Gln Thr Lys Glu Gln Tyr His Phe Cys Tyr Asp Ile Val 
385                 390                 395                 400


Leu Glu Val Leu Arg Lys Leu Leu Thr Leu Asp 
                405                 410


<210>  730
<211>  2444
<212>  DNA
<213>  Homo sapiens

<400>  730
ctgtggctct gtggtagggg aatgccacca actccctgag gagcagccgt gtggtatgat     60

tgtaaacgat tatgagggaa atgactctga agcagaagac ttgaatttca gggagacttt    120

gccttcatca agtcaggaaa acacacctag atcaaaggtt tttgaaaata aagttaattc    180

agagaaggta aaactttctc ttcggaattt cccacataat gattatgagg atgtttttga    240

agagccttca gaaagtggca gtgatcccag catgtggaca gccagaggcc ccttcagaag    300

agacaggtgg agcagtgagg atgaggaggc tgcagggcca tcacaggctc tctcccctct    360

actttctgat acgcgcaaaa ttgtttctga aggagaacta gatcagttgg ctcagattcg    420

gccattaata ttcaattttc atgagcagac agccatcaag gattgtttga aaatccttga    480

ggaaaaaaca gcagcgtatg atatcatgca ggaatttatg acgggaacta gtcactctgt    540

aaaacagttg cagttcacca agtggccaga ccatggcact cctgcctcag cagatagctt    600

cataaaatat attcgttatg caaggaagag ccaccttaca ggacccatgg ttgttcactg    660

cagtgccggc ataggccgga caggggtgtt cctatgtgtg gatgtcgtgt tctgtgccat    720

cgtaaagaac tgttcattca acatcatgga tatagtggcc caaatgagag aacaacgttc    780

tggcatggtt caaacgaagg agcagtatca cttttgttac gatattgtgc ttgaagttct    840

tcggaaactt ctgactttgg attaagaaag acttctgttg cctctcactt gaaattacca    900

agtgggtttg cacctcctca taaagaacat gtttgcactg tgctgaaggg ctttgctatg    960

catacaatct gctttcttgg tttatcagtt tattttcttt ctaaaagctc cctgaagggc   1020

aatatcattt ggcttggggt gatcagtgtt tacttattga tcttgctaga caatatcaaa   1080

ataacttccc acattttcca gtgaaacaga tgttacataa aacgattgca gcttggctat   1140

ttggttgaag ggattacaga gcccaataaa ggatttaaaa tatattcatt aagattttat   1200

ttggaaaggt ggctggagag agctgaggat ttccaggact ttgtaagttc ttattctggg   1260

agaacataag gccaataatc atgacctctt ccaggcattt ttaagacaga tgtctattca   1320

tgttctttag ctagagcctg tactttttgc tggcatttga ataacccagt ttaaaaagag   1380

tccagttagg gtggactaac tttggacaca aattggcttc catttcctac attttcatac   1440

tgctgccttc ctacagctgc tagaccaaga cctgttggtc tgggaagcat ttcatggata   1500

gggagagctc ctctcggtga acagtccaaa actaaaatag atgtttatat agaaagccca   1560

agaggagatt tttgccatgc ctgagttctt tcctatccca ccctaacact taacatatta   1620

cttagtctgc tttgttaaaa gcaagtatta cctttaactt gcctcttact ctttgccctt   1680

tagctaacta ataaagtttg atataggcat tattatataa ttctgagtca ttcatggtat   1740

atctcatgtt tgatgtattt ttcaaactaa gatctatgat agtttttttt ccagagttcc   1800

attaaatcat ttatttcctt tactttctca cctctgttga aacatttaga aactggattt   1860

gggaacccaa ttttggaaaa ccagattcat agtcatgaaa atggaaactt ccatattctg   1920

tttttgaaaa gatgtggcca ttattacagt aattttatta taggactttg cctcgtacaa   1980

ttaatagtga tattttggac aaggagttct ggtgacaagc tatacctaat tataagctat   2040

aaaacaatag atatgagtgt ttgtacagtt taactcaatg gagatcagaa tattctatgt   2100

attgagaaaa tgtttaatat caatctataa atcttgaatt tctaagaggc ttattttgtt   2160

cttttggctg aatgagtata tttgaattgg ttgaataatt aataattctc attgtaaaaa   2220

taattatatg ccaaaaatat atttgatgtt aaatcaaata gatgattctg tttacattgt   2280

tcatatgaat aataatctgt gttaatttca ttttgataat tggcctttaa tatttgtatc   2340

tctaatttta ttttctctct gttactgtaa aataatagct ataatgtata acaattttct   2400

tcagaagaat tctatgctat tattaaaata aaatatttac tgtg                    2444


<210>  731
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  731

Met Ile Val Asn Asp Tyr Glu Gly Asn Asp Ser Glu Ala Glu Asp Leu 
1               5                   10                  15


Asn Phe Arg Glu Thr Leu Pro Ser Ser Ser Gln Glu Asn Thr Pro Arg 
            20                  25                  30


Ser Lys Val Phe Glu Asn Lys Val Asn Ser Glu Lys Val Lys Leu Ser 
        35                  40                  45


Leu Arg Asn Phe Pro His Asn Asp Tyr Glu Asp Val Phe Glu Glu Pro 
    50                  55                  60


Ser Glu Ser Gly Ser Asp Pro Ser Met Trp Thr Ala Arg Gly Pro Phe 
65                  70                  75                  80


Arg Arg Asp Arg Trp Ser Ser Glu Asp Glu Glu Ala Ala Gly Pro Ser 
                85                  90                  95


Gln Ala Leu Ser Pro Leu Leu Ser Asp Thr Arg Lys Ile Val Ser Glu 
            100                 105                 110


Gly Glu Leu Asp Gln Leu Ala Gln Ile Arg Pro Leu Ile Phe Asn Phe 
        115                 120                 125


His Glu Gln Thr Ala Ile Lys Asp Cys Leu Lys Ile Leu Glu Glu Lys 
    130                 135                 140


Thr Ala Ala Tyr Asp Ile Met Gln Glu Phe Met Thr Gly Thr Ser His 
145                 150                 155                 160


Ser Val Lys Gln Leu Gln Phe Thr Lys Trp Pro Asp His Gly Thr Pro 
                165                 170                 175


Ala Ser Ala Asp Ser Phe Ile Lys Tyr Ile Arg Tyr Ala Arg Lys Ser 
            180                 185                 190


His Leu Thr Gly Pro Met Val Val His Cys Ser Ala Gly Ile Gly Arg 
        195                 200                 205


Thr Gly Val Phe Leu Cys Val Asp Val Val Phe Cys Ala Ile Val Lys 
    210                 215                 220


Asn Cys Ser Phe Asn Ile Met Asp Ile Val Ala Gln Met Arg Glu Gln 
225                 230                 235                 240


Arg Ser Gly Met Val Gln Thr Lys Glu Gln Tyr His Phe Cys Tyr Asp 
                245                 250                 255


Ile Val Leu Glu Val Leu Arg Lys Leu Leu Thr Leu Asp 
            260                 265


<210>  732
<211>  2321
<212>  DNA
<213>  Homo sapiens

<400>  732
ctgtggctct gtggtagggg aatgccacca actccctgag gagcagccgt gtggtatgat     60

tgatgattca acacgcgttc ctcttggaaa aagcaaggac tacatcaatg ctagttatat    120

tagaatagtc aattgtggag aagagtattt ttatatcgct actcaaggac cactgctgag    180

caccatagat gacttttggc aaatggtgtt ggaaaataat tcaaatgtta ttgccatgat    240

aaccagagag atagaaggtg gaattatcaa atgctaccat tactggccca tttctctgaa    300

gaagccattg gaattgaaac acttccgtgt attcctggag aactaccaga tacttcaata    360

tttcatcatt cgaatgtttc aagttgtgga gaagtccacg ggaactagtc actctgtaaa    420

acagttgcag ttcaccaagt ggccagacca tggcactcct gcctcagcag atagcttcat    480

aaaatatatt cgttatgcaa ggaagagcca ccttacagga cccatggttg ttcactgcag    540

tgccggcata ggccggacag gggtgttcct atgtgtggat gtcgtgttct gtgccatcgt    600

aaagaactgt tcattcaaca tcatggatat agtggcccaa atgagagaac aacgttctgg    660

catggttcaa acgaaggagc agtatcactt ttgttacgat attgtgcttg aagttcttcg    720

gaaacttctg actttggatt aagaaagact tctgttgcct ctcacttgaa attaccaagt    780

gggtttgcac ctcctcataa agaacatgtt tgcactgtgc tgaagggctt tgctatgcat    840

acaatctgct ttcttggttt atcagtttat tttctttcta aaagctccct gaagggcaat    900

atcatttggc ttggggtgat cagtgtttac ttattgatct tgctagacaa tatcaaaata    960

acttcccaca ttttccagtg aaacagatgt tacataaaac gattgcagct tggctatttg   1020

gttgaaggga ttacagagcc caataaagga tttaaaatat attcattaag attttatttg   1080

gaaaggtggc tggagagagc tgaggatttc caggactttg taagttctta ttctgggaga   1140

acataaggcc aataatcatg acctcttcca ggcattttta agacagatgt ctattcatgt   1200

tctttagcta gagcctgtac tttttgctgg catttgaata acccagttta aaaagagtcc   1260

agttagggtg gactaacttt ggacacaaat tggcttccat ttcctacatt ttcatactgc   1320

tgccttccta cagctgctag accaagacct gttggtctgg gaagcatttc atggataggg   1380

agagctcctc tcggtgaaca gtccaaaact aaaatagatg tttatataga aagcccaaga   1440

ggagattttt gccatgcctg agttctttcc tatcccaccc taacacttaa catattactt   1500

agtctgcttt gttaaaagca agtattacct ttaacttgcc tcttactctt tgccctttag   1560

ctaactaata aagtttgata taggcattat tatataattc tgagtcattc atggtatatc   1620

tcatgtttga tgtatttttc aaactaagat ctatgatagt tttttttcca gagttccatt   1680

aaatcattta tttcctttac tttctcacct ctgttgaaac atttagaaac tggatttggg   1740

aacccaattt tggaaaacca gattcatagt catgaaaatg gaaacttcca tattctgttt   1800

ttgaaaagat gtggccatta ttacagtaat tttattatag gactttgcct cgtacaatta   1860

atagtgatat tttggacaag gagttctggt gacaagctat acctaattat aagctataaa   1920

acaatagata tgagtgtttg tacagtttaa ctcaatggag atcagaatat tctatgtatt   1980

gagaaaatgt ttaatatcaa tctataaatc ttgaatttct aagaggctta ttttgttctt   2040

ttggctgaat gagtatattt gaattggttg aataattaat aattctcatt gtaaaaataa   2100

ttatatgcca aaaatatatt tgatgttaaa tcaaatagat gattctgttt acattgttca   2160

tatgaataat aatctgtgtt aatttcattt tgataattgg cctttaatat ttgtatctct   2220

aattttattt tctctctgtt actgtaaaat aatagctata atgtataaca attttcttca   2280

gaagaattct atgctattat taaaataaaa tatttactgt g                       2321


<210>  733
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  733

Met Ile Asp Asp Ser Thr Arg Val Pro Leu Gly Lys Ser Lys Asp Tyr 
1               5                   10                  15


Ile Asn Ala Ser Tyr Ile Arg Ile Val Asn Cys Gly Glu Glu Tyr Phe 
            20                  25                  30


Tyr Ile Ala Thr Gln Gly Pro Leu Leu Ser Thr Ile Asp Asp Phe Trp 
        35                  40                  45


Gln Met Val Leu Glu Asn Asn Ser Asn Val Ile Ala Met Ile Thr Arg 
    50                  55                  60


Glu Ile Glu Gly Gly Ile Ile Lys Cys Tyr His Tyr Trp Pro Ile Ser 
65                  70                  75                  80


Leu Lys Lys Pro Leu Glu Leu Lys His Phe Arg Val Phe Leu Glu Asn 
                85                  90                  95


Tyr Gln Ile Leu Gln Tyr Phe Ile Ile Arg Met Phe Gln Val Val Glu 
            100                 105                 110


Lys Ser Thr Gly Thr Ser His Ser Val Lys Gln Leu Gln Phe Thr Lys 
        115                 120                 125


Trp Pro Asp His Gly Thr Pro Ala Ser Ala Asp Ser Phe Ile Lys Tyr 
    130                 135                 140


Ile Arg Tyr Ala Arg Lys Ser His Leu Thr Gly Pro Met Val Val His 
145                 150                 155                 160


Cys Ser Ala Gly Ile Gly Arg Thr Gly Val Phe Leu Cys Val Asp Val 
                165                 170                 175


Val Phe Cys Ala Ile Val Lys Asn Cys Ser Phe Asn Ile Met Asp Ile 
            180                 185                 190


Val Ala Gln Met Arg Glu Gln Arg Ser Gly Met Val Gln Thr Lys Glu 
        195                 200                 205


Gln Tyr His Phe Cys Tyr Asp Ile Val Leu Glu Val Leu Arg Lys Leu 
    210                 215                 220


Leu Thr Leu Asp 
225


<210>  734
<211>  2319
<212>  DNA
<213>  Homo sapiens

<400>  734
ctgtggctct gtggtagggg aatgccacca actccctgag gagcagccgt gtggtatgat     60

tgtaaacgat tatgagggaa atgactctga agcagaagac ttgaatttca gggagacttt    120

gccttcatca agtcaggaaa acacacctag atcaaaggtt tttgaaaata aagttaattc    180

agagaaggta aaactttctc ttcggaattt cccacataat gattatgagg atgtttttga    240

agagccttca gaaagtggca gtgatcccag catgtggaca gccagaggcc ccttcagaag    300

agacaggtgg agcagtgagg atgaggaggc tgcagggcca tcacaggctc tctcccctct    360

actttctgat acgcgcaaaa ttgtttctga aggagaacta gatcagttgg ctcagattcg    420

gccattaata ttcaattttc atgagcagac agccatcaag gattgtttga aaatccttga    480

ggaaaaaaca gcagcgtatg atatcatgca ggaatttatg gctttagaac ttaagaatct    540

gcctggtgag ttcaactctg ggaatcaacc aagcaacaga gaaaaaaaca gataccgaga    600

tattcttcca tttcaacatc atggatatag tggcccaaat gagagaacaa cgttctggca    660

tggttcaaac gaaggagcag tatcactttt gttacgatat tgtgcttgaa gttcttcgga    720

aacttctgac tttggattaa gaaagacttc tgttgcctct cacttgaaat taccaagtgg    780

gtttgcacct cctcataaag aacatgtttg cactgtgctg aagggctttg ctatgcatac    840

aatctgcttt cttggtttat cagtttattt tctttctaaa agctccctga agggcaatat    900

catttggctt ggggtgatca gtgtttactt attgatcttg ctagacaata tcaaaataac    960

ttcccacatt ttccagtgaa acagatgtta cataaaacga ttgcagcttg gctatttggt   1020

tgaagggatt acagagccca ataaaggatt taaaatatat tcattaagat tttatttgga   1080

aaggtggctg gagagagctg aggatttcca ggactttgta agttcttatt ctgggagaac   1140

ataaggccaa taatcatgac ctcttccagg catttttaag acagatgtct attcatgttc   1200

tttagctaga gcctgtactt tttgctggca tttgaataac ccagtttaaa aagagtccag   1260

ttagggtgga ctaactttgg acacaaattg gcttccattt cctacatttt catactgctg   1320

ccttcctaca gctgctagac caagacctgt tggtctggga agcatttcat ggatagggag   1380

agctcctctc ggtgaacagt ccaaaactaa aatagatgtt tatatagaaa gcccaagagg   1440

agatttttgc catgcctgag ttctttccta tcccacccta acacttaaca tattacttag   1500

tctgctttgt taaaagcaag tattaccttt aacttgcctc ttactctttg ccctttagct   1560

aactaataaa gtttgatata ggcattatta tataattctg agtcattcat ggtatatctc   1620

atgtttgatg tatttttcaa actaagatct atgatagttt tttttccaga gttccattaa   1680

atcatttatt tcctttactt tctcacctct gttgaaacat ttagaaactg gatttgggaa   1740

cccaattttg gaaaaccaga ttcatagtca tgaaaatgga aacttccata ttctgttttt   1800

gaaaagatgt ggccattatt acagtaattt tattatagga ctttgcctcg tacaattaat   1860

agtgatattt tggacaagga gttctggtga caagctatac ctaattataa gctataaaac   1920

aatagatatg agtgtttgta cagtttaact caatggagat cagaatattc tatgtattga   1980

gaaaatgttt aatatcaatc tataaatctt gaatttctaa gaggcttatt ttgttctttt   2040

ggctgaatga gtatatttga attggttgaa taattaataa ttctcattgt aaaaataatt   2100

atatgccaaa aatatatttg atgttaaatc aaatagatga ttctgtttac attgttcata   2160

tgaataataa tctgtgttaa tttcattttg ataattggcc tttaatattt gtatctctaa   2220

ttttattttc tctctgttac tgtaaaataa tagctataat gtataacaat tttcttcaga   2280

agaattctat gctattatta aaataaaata tttactgtg                          2319


<210>  735
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  735

Met Ile Val Asn Asp Tyr Glu Gly Asn Asp Ser Glu Ala Glu Asp Leu 
1               5                   10                  15


Asn Phe Arg Glu Thr Leu Pro Ser Ser Ser Gln Glu Asn Thr Pro Arg 
            20                  25                  30


Ser Lys Val Phe Glu Asn Lys Val Asn Ser Glu Lys Val Lys Leu Ser 
        35                  40                  45


Leu Arg Asn Phe Pro His Asn Asp Tyr Glu Asp Val Phe Glu Glu Pro 
    50                  55                  60


Ser Glu Ser Gly Ser Asp Pro Ser Met Trp Thr Ala Arg Gly Pro Phe 
65                  70                  75                  80


Arg Arg Asp Arg Trp Ser Ser Glu Asp Glu Glu Ala Ala Gly Pro Ser 
                85                  90                  95


Gln Ala Leu Ser Pro Leu Leu Ser Asp Thr Arg Lys Ile Val Ser Glu 
            100                 105                 110


Gly Glu Leu Asp Gln Leu Ala Gln Ile Arg Pro Leu Ile Phe Asn Phe 
        115                 120                 125


His Glu Gln Thr Ala Ile Lys Asp Cys Leu Lys Ile Leu Glu Glu Lys 
    130                 135                 140


Thr Ala Ala Tyr Asp Ile Met Gln Glu Phe Met Ala Leu Glu Leu Lys 
145                 150                 155                 160


Asn Leu Pro Gly Glu Phe Asn Ser Gly Asn Gln Pro Ser Asn Arg Glu 
                165                 170                 175


Lys Asn Arg Tyr Arg Asp Ile Leu Pro Phe Gln His His Gly Tyr Ser 
            180                 185                 190


Gly Pro Asn Glu Arg Thr Thr Phe Trp His Gly Ser Asn Glu Gly Ala 
        195                 200                 205


Val Ser Leu Leu Leu Arg Tyr Cys Ala 
    210                 215


<210>  736
<211>  2076
<212>  DNA
<213>  Homo sapiens

<400>  736
ctgtggctct gtggtagggg aatgccacca actccctgag gagcagccgt gtggtatgat     60

tgtaaacgat tatgagggaa atgactctga agcagaagac ttgaatttca gggagacttt    120

gccttcatca agtcaggaaa acacacctag atcaaaggtt tttgaaaata aagttaattc    180

agagaaggta aaactttctc ttcggaattt cccacataat gattatgagg atgtttttga    240

agagccttca gaaagtggca gtgatcccag catgtggaca gccagaggcc ccttcagaag    300

agacaggtgg agcagtgagg atgaggaggc tgcagggcca tcacaggctc tctcccctct    360

actttctgtt caacatcatg gatatagtgg cccaaatgag agaacaacgt tctggcatgg    420

ttcaaacgaa ggagcagtat cacttttgtt acgatattgt gcttgaagtt cttcggaaac    480

ttctgacttt ggattaagaa agacttctgt tgcctctcac ttgaaattac caagtgggtt    540

tgcacctcct cataaagaac atgtttgcac tgtgctgaag ggctttgcta tgcatacaat    600

ctgctttctt ggtttatcag tttattttct ttctaaaagc tccctgaagg gcaatatcat    660

ttggcttggg gtgatcagtg tttacttatt gatcttgcta gacaatatca aaataacttc    720

ccacattttc cagtgaaaca gatgttacat aaaacgattg cagcttggct atttggttga    780

agggattaca gagcccaata aaggatttaa aatatattca ttaagatttt atttggaaag    840

gtggctggag agagctgagg atttccagga ctttgtaagt tcttattctg ggagaacata    900

aggccaataa tcatgacctc ttccaggcat ttttaagaca gatgtctatt catgttcttt    960

agctagagcc tgtacttttt gctggcattt gaataaccca gtttaaaaag agtccagtta   1020

gggtggacta actttggaca caaattggct tccatttcct acattttcat actgctgcct   1080

tcctacagct gctagaccaa gacctgttgg tctgggaagc atttcatgga tagggagagc   1140

tcctctcggt gaacagtcca aaactaaaat agatgtttat atagaaagcc caagaggaga   1200

tttttgccat gcctgagttc tttcctatcc caccctaaca cttaacatat tacttagtct   1260

gctttgttaa aagcaagtat tacctttaac ttgcctctta ctctttgccc tttagctaac   1320

taataaagtt tgatataggc attattatat aattctgagt cattcatggt atatctcatg   1380

tttgatgtat ttttcaaact aagatctatg atagtttttt ttccagagtt ccattaaatc   1440

atttatttcc tttactttct cacctctgtt gaaacattta gaaactggat ttgggaaccc   1500

aattttggaa aaccagattc atagtcatga aaatggaaac ttccatattc tgtttttgaa   1560

aagatgtggc cattattaca gtaattttat tataggactt tgcctcgtac aattaatagt   1620

gatattttgg acaaggagtt ctggtgacaa gctataccta attataagct ataaaacaat   1680

agatatgagt gtttgtacag tttaactcaa tggagatcag aatattctat gtattgagaa   1740

aatgtttaat atcaatctat aaatcttgaa tttctaagag gcttattttg ttcttttggc   1800

tgaatgagta tatttgaatt ggttgaataa ttaataattc tcattgtaaa aataattata   1860

tgccaaaaat atatttgatg ttaaatcaaa tagatgattc tgtttacatt gttcatatga   1920

ataataatct gtgttaattt cattttgata attggccttt aatatttgta tctctaattt   1980

tattttctct ctgttactgt aaaataatag ctataatgta taacaatttt cttcagaaga   2040

attctatgct attattaaaa taaaatattt actgtg                             2076


<210>  737
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  737

Met Ile Val Asn Asp Tyr Glu Gly Asn Asp Ser Glu Ala Glu Asp Leu 
1               5                   10                  15


Asn Phe Arg Glu Thr Leu Pro Ser Ser Ser Gln Glu Asn Thr Pro Arg 
            20                  25                  30


Ser Lys Val Phe Glu Asn Lys Val Asn Ser Glu Lys Val Lys Leu Ser 
        35                  40                  45


Leu Arg Asn Phe Pro His Asn Asp Tyr Glu Asp Val Phe Glu Glu Pro 
    50                  55                  60


Ser Glu Ser Gly Ser Asp Pro Ser Met Trp Thr Ala Arg Gly Pro Phe 
65                  70                  75                  80


Arg Arg Asp Arg Trp Ser Ser Glu Asp Glu Glu Ala Ala Gly Pro Ser 
                85                  90                  95


Gln Ala Leu Ser Pro Leu Leu Ser Val Gln His His Gly Tyr Ser Gly 
            100                 105                 110


Pro Asn Glu Arg Thr Thr Phe Trp His Gly Ser Asn Glu Gly Ala Val 
        115                 120                 125


Ser Leu Leu Leu Arg Tyr Cys Ala 
    130                 135


<210>  738
<211>  2872
<212>  DNA
<213>  Homo sapiens

<400>  738
tggacccaac tggcgaggct gctggggttg cagcgggaca gttggggcgg ccccgcaggc     60

ccagtaaacg attatgaggg aaatgactct gaagcagaag acttgaattt cagggagact    120

ttgccttcat caagtcagga aaacacacct agatcaaagg tttttgaaaa taaagttaat    180

tcagagaagg taaaactttc tcttcggaat ttcccacata atgattatga ggatgttttt    240

gaagagcctt cagaaagtgg cagtgatccc agcatgtgga cagccagagg ccccttcaga    300

agagacaggt ggagcagtga ggatgaggag gctgcagggc catcacaggc tctctcccct    360

ctactttctg atacgcgcaa aattgtttct gaaggagaac tagatcagtt ggctcagatt    420

cggccattaa tattcaattt tcatgagcag acagccatca aggattgttt gaaaatcctt    480

gaggaaaaaa cagcagcgta tgatatcatg caggaattta tggctttaga acttaagaat    540

ctgcctggtg agttcaactc tgggaatcaa ccaagcaaca gagaaaaaaa cagataccga    600

gatattcttc catatgattc aacacgcgtt cctcttggaa aaagcaagga ctacatcaat    660

gctagttata ttagaatagt caattgtgga gaagagtatt tttatatcgc tactcaagga    720

ccactgctga gcaccataga tgacttttgg caaatggtgt tggaaaataa ttcaaatgtt    780

attgccatga taaccagaga gatagaaggt ggaattatca aatgctacca ttactggccc    840

atttctctga agaagccatt ggaattgaaa cacttccgtg tattcctgga gaactaccag    900

atacttcaat atttcatcat tcgaatgttt caagttgtgg agaagtccac gggaactagt    960

cactctgtaa aacagttgca gttcaccaag tggccagacc atggcactcc tgcctcagca   1020

gatagcttca taaaatatat tcgttatgca aggaagagcc accttacagg acccatggtt   1080

gttcactgca gtgccggcat aggccggaca ggggtgttcc tatgtgtgga tgtcgtgttc   1140

tgtgccatcg taaagaactg ttcattcaac atcatggata tagtggccca aatgagagaa   1200

caacgttctg gcatggttca aacgaaggag cagtatcact tttgttacga tattgtgctt   1260

gaagttcttc ggaaacttct gactttggat taagaaagac ttctgttgcc tctcacttga   1320

aattaccaag tgggtttgca cctcctcata aagaacatgt ttgcactgtg ctgaagggct   1380

ttgctatgca tacaatctgc tttcttggtt tatcagttta ttttctttct aaaagctccc   1440

tgaagggcaa tatcatttgg cttggggtga tcagtgttta cttattgatc ttgctagaca   1500

atatcaaaat aacttcccac attttccagt gaaacagatg ttacataaaa cgattgcagc   1560

ttggctattt ggttgaaggg attacagagc ccaataaagg atttaaaata tattcattaa   1620

gattttattt ggaaaggtgg ctggagagag ctgaggattt ccaggacttt gtaagttctt   1680

attctgggag aacataaggc caataatcat gacctcttcc aggcattttt aagacagatg   1740

tctattcatg ttctttagct agagcctgta ctttttgctg gcatttgaat aacccagttt   1800

aaaaagagtc cagttagggt ggactaactt tggacacaaa ttggcttcca tttcctacat   1860

tttcatactg ctgccttcct acagctgcta gaccaagacc tgttggtctg ggaagcattt   1920

catggatagg gagagctcct ctcggtgaac agtccaaaac taaaatagat gtttatatag   1980

aaagcccaag aggagatttt tgccatgcct gagttctttc ctatcccacc ctaacactta   2040

acatattact tagtctgctt tgttaaaagc aagtattacc tttaacttgc ctcttactct   2100

ttgcccttta gctaactaat aaagtttgat ataggcatta ttatataatt ctgagtcatt   2160

catggtatat ctcatgtttg atgtattttt caaactaaga tctatgatag ttttttttcc   2220

agagttccat taaatcattt atttccttta ctttctcacc tctgttgaaa catttagaaa   2280

ctggatttgg gaacccaatt ttggaaaacc agattcatag tcatgaaaat ggaaacttcc   2340

atattctgtt tttgaaaaga tgtggccatt attacagtaa ttttattata ggactttgcc   2400

tcgtacaatt aatagtgata ttttggacaa ggagttctgg tgacaagcta tacctaatta   2460

taagctataa aacaatagat atgagtgttt gtacagttta actcaatgga gatcagaata   2520

ttctatgtat tgagaaaatg tttaatatca atctataaat cttgaatttc taagaggctt   2580

attttgttct tttggctgaa tgagtatatt tgaattggtt gaataattaa taattctcat   2640

tgtaaaaata attatatgcc aaaaatatat ttgatgttaa atcaaataga tgattctgtt   2700

tacattgttc atatgaataa taatctgtgt taatttcatt ttgataattg gcctttaata   2760

tttgtatctc taattttatt ttctctctgt tactgtaaaa taatagctat aatgtataac   2820

aattttcttc agaagaattc tatgctatta ttaaaataaa atatttactg tg           2872


<210>  739
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  739

Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser Glu 
1               5                   10                  15


Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu Ser 
            20                  25                  30


Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala Gln 
        35                  40                  45


Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys Asp 
    50                  55                  60


Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met Gln 
65                  70                  75                  80


Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro Gly Glu Phe Asn Ser 
                85                  90                  95


Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg Tyr Arg Asp Ile Leu 
            100                 105                 110


Pro Tyr Asp Ser Thr Arg Val Pro Leu Gly Lys Ser Lys Asp Tyr Ile 
        115                 120                 125


Asn Ala Ser Tyr Ile Arg Ile Val Asn Cys Gly Glu Glu Tyr Phe Tyr 
    130                 135                 140


Ile Ala Thr Gln Gly Pro Leu Leu Ser Thr Ile Asp Asp Phe Trp Gln 
145                 150                 155                 160


Met Val Leu Glu Asn Asn Ser Asn Val Ile Ala Met Ile Thr Arg Glu 
                165                 170                 175


Ile Glu Gly Gly Ile Ile Lys Cys Tyr His Tyr Trp Pro Ile Ser Leu 
            180                 185                 190


Lys Lys Pro Leu Glu Leu Lys His Phe Arg Val Phe Leu Glu Asn Tyr 
        195                 200                 205


Gln Ile Leu Gln Tyr Phe Ile Ile Arg Met Phe Gln Val Val Glu Lys 
    210                 215                 220


Ser Thr Gly Thr Ser His Ser Val Lys Gln Leu Gln Phe Thr Lys Trp 
225                 230                 235                 240


Pro Asp His Gly Thr Pro Ala Ser Ala Asp Ser Phe Ile Lys Tyr Ile 
                245                 250                 255


Arg Tyr Ala Arg Lys Ser His Leu Thr Gly Pro Met Val Val His Cys 
            260                 265                 270


Ser Ala Gly Ile Gly Arg Thr Gly Val Phe Leu Cys Val Asp Val Val 
        275                 280                 285


Phe Cys Ala Ile Val Lys Asn Cys Ser Phe Asn Ile Met Asp Ile Val 
    290                 295                 300


Ala Gln Met Arg Glu Gln Arg Ser Gly Met Val Gln Thr Lys Glu Gln 
305                 310                 315                 320


Tyr His Phe Cys Tyr Asp Ile Val Leu Glu Val Leu Arg Lys Leu Leu 
                325                 330                 335


Thr Leu Asp 



<210>  740
<211>  2226
<212>  DNA
<213>  Homo sapiens

<400>  740
tggacccaac tggcgaggct gctggggttg cagcgggaca gttggggcgg ccccgcaggc     60

ccaggttttt gaaaataaag ttaattcaga gaaggtaaaa ctttctcttc ggaatttccc    120

acataatgat tatgaggatg tttttgaaga gccttcagaa agtggcagtg atcccagcat    180

gtggacagcc agaggcccct tcagaagaga caggtggagc agtgaggatg aggaggctgc    240

agggccatca caggctctct cccctctact ttctgatacg cgcaaaattg tttctgaagg    300

agaactagat cagttggctc agattcggcc attaatattc aattttcatg agcagacagc    360

catcaaggat tgtttgaaaa tccttgagga aaaaacagca gcgtatgata tcatgcagga    420

atttatggct ttagaactta agaatctgcc tggtgagttc aactctggga atcaaccaag    480

caacagagaa aaaaacagat accgagatat tcttccattt caacatcatg gatatagtgg    540

cccaaatgag agaacaacgt tctggcatgg ttcaaacgaa ggagcagtat cacttttgtt    600

acgatattgt gcttgaagtt cttcggaaac ttctgacttt ggattaagaa agacttctgt    660

tgcctctcac ttgaaattac caagtgggtt tgcacctcct cataaagaac atgtttgcac    720

tgtgctgaag ggctttgcta tgcatacaat ctgctttctt ggtttatcag tttattttct    780

ttctaaaagc tccctgaagg gcaatatcat ttggcttggg gtgatcagtg tttacttatt    840

gatcttgcta gacaatatca aaataacttc ccacattttc cagtgaaaca gatgttacat    900

aaaacgattg cagcttggct atttggttga agggattaca gagcccaata aaggatttaa    960

aatatattca ttaagatttt atttggaaag gtggctggag agagctgagg atttccagga   1020

ctttgtaagt tcttattctg ggagaacata aggccaataa tcatgacctc ttccaggcat   1080

ttttaagaca gatgtctatt catgttcttt agctagagcc tgtacttttt gctggcattt   1140

gaataaccca gtttaaaaag agtccagtta gggtggacta actttggaca caaattggct   1200

tccatttcct acattttcat actgctgcct tcctacagct gctagaccaa gacctgttgg   1260

tctgggaagc atttcatgga tagggagagc tcctctcggt gaacagtcca aaactaaaat   1320

agatgtttat atagaaagcc caagaggaga tttttgccat gcctgagttc tttcctatcc   1380

caccctaaca cttaacatat tacttagtct gctttgttaa aagcaagtat tacctttaac   1440

ttgcctctta ctctttgccc tttagctaac taataaagtt tgatataggc attattatat   1500

aattctgagt cattcatggt atatctcatg tttgatgtat ttttcaaact aagatctatg   1560

atagtttttt ttccagagtt ccattaaatc atttatttcc tttactttct cacctctgtt   1620

gaaacattta gaaactggat ttgggaaccc aattttggaa aaccagattc atagtcatga   1680

aaatggaaac ttccatattc tgtttttgaa aagatgtggc cattattaca gtaattttat   1740

tataggactt tgcctcgtac aattaatagt gatattttgg acaaggagtt ctggtgacaa   1800

gctataccta attataagct ataaaacaat agatatgagt gtttgtacag tttaactcaa   1860

tggagatcag aatattctat gtattgagaa aatgtttaat atcaatctat aaatcttgaa   1920

tttctaagag gcttattttg ttcttttggc tgaatgagta tatttgaatt ggttgaataa   1980

ttaataattc tcattgtaaa aataattata tgccaaaaat atatttgatg ttaaatcaaa   2040

tagatgattc tgtttacatt gttcatatga ataataatct gtgttaattt cattttgata   2100

attggccttt aatatttgta tctctaattt tattttctct ctgttactgt aaaataatag   2160

ctataatgta taacaatttt cttcagaaga attctatgct attattaaaa taaaatattt   2220

actgtg                                                              2226


<210>  741
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  741

Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser Glu 
1               5                   10                  15


Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu Ser 
            20                  25                  30


Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala Gln 
        35                  40                  45


Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys Asp 
    50                  55                  60


Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met Gln 
65                  70                  75                  80


Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro Gly Glu Phe Asn Ser 
                85                  90                  95


Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg Tyr Arg Asp Ile Leu 
            100                 105                 110


Pro Phe Gln His His Gly Tyr Ser Gly Pro Asn Glu Arg Thr Thr Phe 
        115                 120                 125


Trp His Gly Ser Asn Glu Gly Ala Val Ser Leu Leu Leu Arg Tyr Cys 
    130                 135                 140


Ala 
145


<210>  742
<211>  1885
<212>  DNA
<213>  Homo sapiens

<400>  742
tggacccaac tggcgaggct gctggggttg cagcgggaca gttggggcgg ccccgcaggc     60

ccagtggcag tgatcccagc atgtggacag ccagaggccc cttcagaaga gacaggtgga    120

gcagtgagga tgaggaggct gcagggccat cacaggctct ctcccctcta ctttctgttc    180

aacatcatgg atatagtggc ccaaatgaga gaacaacgtt ctggcatggt tcaaacgaag    240

gagcagtatc acttttgtta cgatattgtg cttgaagttc ttcggaaact tctgactttg    300

gattaagaaa gacttctgtt gcctctcact tgaaattacc aagtgggttt gcacctcctc    360

ataaagaaca tgtttgcact gtgctgaagg gctttgctat gcatacaatc tgctttcttg    420

gtttatcagt ttattttctt tctaaaagct ccctgaaggg caatatcatt tggcttgggg    480

tgatcagtgt ttacttattg atcttgctag acaatatcaa aataacttcc cacattttcc    540

agtgaaacag atgttacata aaacgattgc agcttggcta tttggttgaa gggattacag    600

agcccaataa aggatttaaa atatattcat taagatttta tttggaaagg tggctggaga    660

gagctgagga tttccaggac tttgtaagtt cttattctgg gagaacataa ggccaataat    720

catgacctct tccaggcatt tttaagacag atgtctattc atgttcttta gctagagcct    780

gtactttttg ctggcatttg aataacccag tttaaaaaga gtccagttag ggtggactaa    840

ctttggacac aaattggctt ccatttccta cattttcata ctgctgcctt cctacagctg    900

ctagaccaag acctgttggt ctgggaagca tttcatggat agggagagct cctctcggtg    960

aacagtccaa aactaaaata gatgtttata tagaaagccc aagaggagat ttttgccatg   1020

cctgagttct ttcctatccc accctaacac ttaacatatt acttagtctg ctttgttaaa   1080

agcaagtatt acctttaact tgcctcttac tctttgccct ttagctaact aataaagttt   1140

gatataggca ttattatata attctgagtc attcatggta tatctcatgt ttgatgtatt   1200

tttcaaacta agatctatga tagttttttt tccagagttc cattaaatca tttatttcct   1260

ttactttctc acctctgttg aaacatttag aaactggatt tgggaaccca attttggaaa   1320

accagattca tagtcatgaa aatggaaact tccatattct gtttttgaaa agatgtggcc   1380

attattacag taattttatt ataggacttt gcctcgtaca attaatagtg atattttgga   1440

caaggagttc tggtgacaag ctatacctaa ttataagcta taaaacaata gatatgagtg   1500

tttgtacagt ttaactcaat ggagatcaga atattctatg tattgagaaa atgtttaata   1560

tcaatctata aatcttgaat ttctaagagg cttattttgt tcttttggct gaatgagtat   1620

atttgaattg gttgaataat taataattct cattgtaaaa ataattatat gccaaaaata   1680

tatttgatgt taaatcaaat agatgattct gtttacattg ttcatatgaa taataatctg   1740

tgttaatttc attttgataa ttggccttta atatttgtat ctctaatttt attttctctc   1800

tgttactgta aaataatagc tataatgtat aacaattttc ttcagaagaa ttctatgcta   1860

ttattaaaat aaaatattta ctgtg                                         1885


<210>  743
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  743

Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser Glu 
1               5                   10                  15


Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu Ser 
            20                  25                  30


Val Gln His His Gly Tyr Ser Gly Pro Asn Glu Arg Thr Thr Phe Trp 
        35                  40                  45


His Gly Ser Asn Glu Gly Ala Val Ser Leu Leu Leu Arg Tyr Cys Ala 
    50                  55                  60


<210>  744
<211>  2631
<212>  DNA
<213>  Homo sapiens

<400>  744
ataataataa taataataat aataataata atctacaatg tcatttccca tccaagcttg     60

acttctacct ttactttctg atatggtttt gccatgtccc cacccaaatc tcatcatgaa    120

ttataatccc cataatcctg atgtgtcgag ggaggggcct agggggaggt gattggatca    180

tgggggcagt tatcctcatg ctgttcttgt gatattcagt aagtcctcat gagatcttat    240

agggttttgt tttgtttttt gggatggagt cttgctctgt tgtccaggca ggagtgccat    300

ggcatgatct tggctcactg cagtctctgc ctcttgagtt ccattgattc tcctgcctca    360

gcctcctgag tagctgggat tacaggcatg caccaccaca cccagctaat ttttgtattt    420

ttagtagaga caggatttca ctacattagc taggctggtc tcaaactcct gacctcagtt    480

gatccacctg ccttggcctc ccaaagtact agggttacaa gtgtgagcca ccgtgcccag    540

ctgagatctg atggttttat acatgtttga cagttgctcc ttcacatgtt cccactctct    600

gtgcggccac catgtaagtc ggacctgccc ttctgccatg attgtaagtt tcctgaagga    660

cttccccctc tgccatgatt gttaagtttc ctgaggcctc cccagccatg tgaaactgag    720

tcaattaaac ctctttcctt taaaaattac ccaacctcag gtgtttcttt atatcagtgt    780

gaaaacagac tgctatactt tctgatactc atgcttaagc aattggggaa ttcagactac    840

ctgggatcaa accatggccc cacccttagc agtcatgtga ccttggggag gttacttacc    900

ttctccatct caacaacttc tgtaaaatct gtaacatgag attgtttctg agggttaaat    960

gagcatagca cagtggggac actgtcaggc acacactact tgccagatgt cgagtattca   1020

tctttattga aataggactg tggtaagcca ctttatggct ctcgattttg tatgagaaaa   1080

tcatgcttag tgccttgtta gtaaaagaaa gaaaacctga aagtccctgc catggaagga   1140

agaaatagcg gggagaaaag ggagttggta agtttcagca tttcagagct tggaggtgcc   1200

agttaggttt ctattttatg gagaaggagg tggaggcagg atgggtccta aggtgtcatt   1260

caaaacacac agccataact ctttattgag agtagagcta gggccccagg gattgctgtg   1320

gtcaagttgc ggacaaaaat gaccactcgt tggaagacag gagaggagtg tttagttaca   1380

aaagcagtca acaattcagg tgtatctata ttcagacagc aaataaaagt tgttcaactt   1440

ggttgctaat gggacccact ctactgaggc tttgtataga actcatagag gaagctggct   1500

tcaaggaatg aactaccctg tgcttttctt aggactaaaa tctcaggaag ctggtgatga   1560

atgaaaacct tagtcccact ggcactgcac gaggggccag gagagcagca gcatcataag   1620

ccacagggtg gggcagccaa ggcaggggca ttctgagctg ttggggaggg gtggcaggca   1680

gggtggggca ctgtgaggtg tcggggaggg cattgtgaag tgtggggtgg ggcattgtgt   1740

gccacatgcc tgggctccca cctggggcca gtgggcttca gtctgtaggt gactacagaa   1800

ggagaaggag ctccgtctgt tctcttttca ggcagttgtt gtgtctctca gcgcttgttg   1860

ggttcacaac ctattaaata agccggctgg tcttcaccct cccagacaag tcaactcagg   1920

ggaggcagca gggtgcgggc cttggcccgc agccctagcc ggggccgggg ccggggccgg   1980

ggccagggct ggtgcccggg gccgcgctgt gaggtgggca ggcgaggagc gggaagacca   2040

tctctgcaag tgcagcatag cctcggccta ggacagcggg agtgcgtggc caaagctgtg   2100

agcagaggca caggtggtgg cagacagtag aggcgcccca tggggaacat actgacctgt   2160

cgtgtgcacc ctagcgtcag cctcgagttt gaccagcagc aggggtcggt gtgtccctct   2220

gaatctgaga tctatgaggc aggagctgag gacaggatgg caggagcgcc catggctgct   2280

gctgtacagc ctgctgaggt gactgttgaa gttggtgagg acctccacat gcaccacgtt   2340

cgtgaccggg agatgcctga agctttggag tttaaccttt ctgccaatcc agaggcaagc   2400

acaatattcc agaggaactc tcaaacagat gctttggagt ttaacccttc tgccaatcca   2460

gaggcaaaca caatattcca gaggaactct caaacagatg ttgtagaaat aagaagaagc   2520

aactgtacaa accatgtaag tgttggtgga aataacccag atgaagaaaa gaatagcaca   2580

gccaattctg gggtctcctc tacagacatc ctgagcttcg gatctggatg a            2631


<210>  745
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  745

Met Gly Asn Ile Leu Thr Cys Arg Val His Pro Ser Val Ser Leu Glu 
1               5                   10                  15


Phe Asp Gln Gln Gln Gly Ser Val Cys Pro Ser Glu Ser Glu Ile Tyr 
            20                  25                  30


Glu Ala Gly Ala Glu Asp Arg Met Ala Gly Ala Pro Met Ala Ala Ala 
        35                  40                  45


Val Gln Pro Ala Glu Val Thr Val Glu Val Gly Glu Asp Leu His Met 
    50                  55                  60


His His Val Arg Asp Arg Glu Met Pro Glu Ala Leu Glu Phe Asn Leu 
65                  70                  75                  80


Ser Ala Asn Pro Glu Ala Ser Thr Ile Phe Gln Arg Asn Ser Gln Thr 
                85                  90                  95


Asp Ala Leu Glu Phe Asn Pro Ser Ala Asn Pro Glu Ala Asn Thr Ile 
            100                 105                 110


Phe Gln Arg Asn Ser Gln Thr Asp Val Val Glu Ile Arg Arg Ser Asn 
        115                 120                 125


Cys Thr Asn His Val Ser Val Gly Gly Asn Asn Pro Asp Glu Glu Lys 
    130                 135                 140


Asn Ser Thr Ala Asn Ser Gly Val Ser Ser Thr Asp Ile Leu Ser Phe 
145                 150                 155                 160


Gly Ser Gly 



<210>  746
<211>  1568
<212>  DNA
<213>  Homo sapiens

<400>  746
ggacctaagg agtcgcagtt gtgaacaggt taggtgccgc gggctggggt aggcggcggt     60

tgggtccgtg gctctggggc actgggaaga tcgcgagtcg tgcgcgtggg aaggtactcc    120

cccggtcctc cgggtcatct ttgctcccca ggagcggcat atttcgcatc tgcctgaggt    180

tagagttact tgttattggt aaatagccac tatggagact aaggaccaga agaaacacag    240

aaagaaaaac agtggaccca aagctgcaaa gaaaaagaag tggcatctgc aggatctcca    300

gctaggagac gaagaaaatg cccagaagag aaatgccaat gcttttgcag ttcagtctgc    360

tgtgtggatg tctcgatcct ttcacaggac tctggatttg aagacacaaa agcatcatat    420

tccagtggtt gatggaactc cactagagcc gccaccaata gcggtagtgg tgacggggcc    480

tccaaagttg gaaagagcac tttgatataa tgcctcattc ggaacttcac ctggcagaag    540

ttcaccgaga tcagaggccc tgtgacgatc gtgtcaggta aaaagcgcag actcaccatt    600

attgaatgtg ggtgtgacat taacatgatg attgatctgg ctaaagtagc agatctggta    660

ctgatgctta tagatgccag ctttgggttt gaaatggaaa tgtttgagtt tctaaacatc    720

tgtcaagcac atggctttcc taaaattctg ggagttctca cccacctcga ctccttcaag    780

cataacaagc aactgaagaa gacaaagaag tgattaaaac acaggttctg gacagaagtt    840

taccaggttg ccaaactgtt ctacctttct ggaatggtgc atggagaata tcaaaaccaa    900

gaaatccaca atctgggcca ttttattaca gttatgaagt ttaggcctct catggcaaac    960

ttttcaccct tatatcctgg cagacattta tttttctagg atggaagatt tgacaaaccc   1020

ggaggatatc caaacaaaca tcaaatgtga cctgcaggtg tcactttatg gttatttaag   1080

aggagcacac ttgaaaaata aaagccaaat tcacatgcca ggggtagaac attttgccat   1140

gagtgacatc agtttcctcc cagacccttg tgttcttcct gaataacaaa agaagtgctg   1200

tttaaataag aaggagcagc tggtttatgc gcctgtttct ggagttgagg gtgtgctgta   1260

tgacaaagac gctgtctgtg ttgaccttgg tggcagccac ggttttcagg acaaggtggg   1320

gctcacccat gagctggtcc agagtctcat ctccacctac tccaccattg atgccaagat   1380

ggcttcaagt cgagtgatgc tgctttccaa ttccaaacca cttgggtcag aggctataga   1440

taatcaaggg taagtctgct ttttttctat ttttaataaa aagatatatt acagaagatc   1500

atatcaccca taattctgcc atcataacac attttggtgg gattcattct atgtcgtttt   1560

gtttttct                                                            1568


<210>  747
<211>  2668
<212>  DNA
<213>  Homo sapiens

<400>  747
ttaaatttca tttatttctt tatgaagaca tgatgtattt gttcactgaa caagggtaga     60

aactgcttaa ccatccccaa tttcatttct ctctgttatg ctataaatta gatgagttac    120

ctctgctaag gttacattct atggttaagt tactttttac tcgtctcaag tgtcaacatc    180

accagtacct atttctgcaa ggatggaaat attctatatc tgtacttttc agccatttag    240

ccattagcca catgtggtta cttaaaatgt acttcagaga aactgaaaaa atgaattctt    300

aattaatttc attctaactc taaatagtca catgtggcta ccatactgga cagctcagac    360

ctagacatcg actggactaa cgaagtggtt tcctaactta aactaaaact taaatttcaa    420

taaaaaattt aaaacgtttt tatgaacttc caataggatc gcagtattac ttttagtacc    480

tgttgactct aaaacttcta aattacagct catctacata catttgaaaa atagcaatat    540

ctgtatgtgt gagatatgac tggttctaga tgatgcctgg aggccccatg gacttacaga    600

gacccttcca gtgatttctg aggtacctgg gaatctgtgg ccaataaatt ggtagtcact    660

gaatctgtga gtttttttgg aatatcgggc tgcataaaat ctgacagctt gattgagaaa    720

aagcggggca gggtgccatt tcattcagtt aaggtcctgt attcattccg tttaataaac    780

gtttgtgtct gtctatgatg tgctagccac tgtgccagaa aatggatata gctatggtct    840

gattgacaga ggaaatccaa actagtatct tccgtgccat gcaataagag ctacattgca    900

aggctgcaga gggtgctact ggagcacaga agtgagtcaa aggcttccca cagacacaca    960

cacgagcgga aacagaaagt ctttatatat caccatatgt caaggaacac tggccgggag   1020

ttaggagagc tgggcactag gaacgctttg aaactgaata gctgtgtgat ttcagaggtt   1080

atattgcttg tctactatat tttactgccg aacttgtact gtttctctcc cttttcttct   1140

tggtgggaaa agcacaattt ggggtcaaca gattcggctc aggtctaagt cgcctgccgg   1200

gaccacgtcg ccaggaaacg acgtctcccc gacaccttcc ctcccagtcc gggctctctg   1260

cagggattca tcccgtcact ctcccaacga ccctcgggca cacctcaggc agatgcgaaa   1320

tatgccgctc ctggggagca aagatgaccc ggaggaccgg gggagtacct tcccacgcgc   1380

acgactcgcg atcttcccag tgccccagag ccacggaccc aaccgccgcc taccccagcc   1440

cgcggcacct aacctgttca caactgcgac tccttaggtc cgcttggaca ccgccggaaa   1500

cggaaattca ccctcgcgcc gactcgccgg aggtaaacaa aaaggcagaa aaaaagggac   1560

cgccgcctgg acgacttgca ggggacagct ggaagaaaga ctcgtcaacg gccgagtgct   1620

ggcgccggcg ccgtctgcgc agtgcgttcc accgggtccg cgtccctccc gattcagccc   1680

caccccgccc tcggaatccg ctgcctcagc tcctgctgtg gcactcccca gcagcttgca   1740

cctcgctcgc ggagtccttg ctgaaggcca gggcagctgt gcggcctggc gcgggttact   1800

tgatgccgtg caaaagccag gagacacatt tggttctggc cgccccggag tcaccgtgcc   1860

cggggcgaat ggactatggc tggattggga gaccacttcc tcctctgtaa agatgacaga   1920

cgagggagat ctcacgttct gggggtgccc tatagccctc ttttggccag aagcggtgga   1980

tcacgcctgt aatcccagcc ctttgggagg ccgaggtagg aggattgctt gagcccagga   2040

gttcaagacc aatctgggca acatagggag gctacgtctc tcaaaaaata aataaataca   2100

taaataaata aaaataaagc cagcgtcgtg gcggggcgcc tgtggtccct gtggtcccag   2160

ctactctgga ggctgaggcg ggacgatcgc ttgagcctgg gaggcagaag ttgtagtgag   2220

ctgagatcga gccactgcac tccagcctgg gcgacagagc aagacactgt ctcaaagaaa   2280

aataaataaa taaaataagg ccctcttttt ccgggaccaa cagactctga gggcagggac   2340

aaactgaccc agcctaaact gcctcgcctt ccctgctccc gggaaagggg ttttccctga   2400

gggaaggtag catcttgcca ttttcttcct gcacagcttt gccttcccag ggatccaccc   2460

attgccacct gaggaaatgc cttggagccc atctaatccc cagcccagct acttgggacg   2520

cctacagaga ctacattgtc agaggatgca tcttcctcta gtcttggagg gtttcttttc   2580

aatatgatcc caccggtgca tgcaaggctc aattctacat caaaaaacta ggcccactcc   2640

tgtcgccgag acccccaggc ttcaggtc                                      2668


<210>  748
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  748

Met Thr Arg Arg Thr Gly Gly Val Pro Ser His Ala His Asp Ser Arg 
1               5                   10                  15


Ser Ser Gln Cys Pro Arg Ala Thr Asp Pro Thr Ala Ala Tyr Pro Ser 
            20                  25                  30


Pro Arg His Leu Thr Cys Ser Gln Leu Arg Leu Leu Arg Ser Ala Trp 
        35                  40                  45


Thr Pro Pro Glu Thr Glu Ile His Pro Arg Ala Asp Ser Pro Glu Val 
    50                  55                  60


Asn Lys Lys Ala Glu Lys Lys Gly Pro Pro Pro Gly Arg Leu Ala Gly 
65                  70                  75                  80


Asp Ser Trp Lys Lys Asp Ser Ser Thr Ala Glu Cys Trp Arg Arg Arg 
                85                  90                  95


Arg Leu Arg Ser Ala Phe His Arg Val Arg Val Pro Pro Asp Ser Ala 
            100                 105                 110


Pro Pro Arg Pro Arg Asn Pro Leu Pro Gln Leu Leu Leu Trp His Ser 
        115                 120                 125


Pro Ala Ala Cys Thr Ser Leu Ala Glu Ser Leu Leu Lys Ala Arg Ala 
    130                 135                 140


Ala Val Arg Pro Gly Ala Gly Tyr Leu Met Pro Cys Lys Ser Gln Glu 
145                 150                 155                 160


Thr His Leu Val Leu Ala Ala Pro Glu Ser Pro Cys Pro Gly Arg Met 
                165                 170                 175


Asp Tyr Gly Trp Ile Gly Arg Pro Leu Pro Pro Leu 
            180                 185


<210>  749
<211>  2052
<212>  DNA
<213>  Homo sapiens

<400>  749
tttttttacg ggagggagct aattggattt taagtctaga tctttgtttt caattcctca     60

acatattcta taaataagac caaattatag tagaaggaga gtaaataagc tattatcttt    120

ttaaagtggt gaagagcact gattaaatat atattagagc cccagccccc gccccagctg    180

cgcgggcccc cgcctggccc atggactgca cagcccagcg ggcgccttga gcgcggtgcg    240

ggtcctcgga gcacccccga ggtgagcgca agcaaggtcc ggcatcatgt gctaggttat    300

tcccagtgcg aggccacact tgggccgtcg gagcagcccc tcctcacttc aggggtcacc    360

ctccccaaga cccattgccc catcatggcc ggggaccggc tccccaggaa ggtgatggac    420

gccaagaagc tggccagcct gctgcggggc gggcctgggg gggcctggtc atcgacagtc    480

actccttcct ggagtacaac agctggcatg tgctcagctc cgtcaacatc tgctgctcca    540

agctggtgaa gtggcggttg cagaagggca aggtgaccat tgtggagttc atccagccgg    600

ctgcacgcag ccaggtggag gccactgagc cacaggacgt ggtggtctat gaccagagca    660

cgcggccgca gacagcttcc tctccatcct gctgagcaag ctggatggct gcttccacag    720

cgtggccggc tgcttccaca gcatggccat catcacgggg ggcttcgcca ccttctcctc    780

ctgcttcccc gacctctgcg agggcgagcc tgctgccctg ctacccatga gcctctccca    840

gtcctgcctg ctcgtgccca gcgtgggcct gaccctcatc ctgcctcacc tctacctggg    900

ctcgcaggaa gacgtcctga acaaggatct gatgacgcag aatggaataa gctacgtcct    960

ctatgccagc aactcctgcc ccaagcctga cttcatctac cagagccact tcttgcaggt   1020

ccccatcaac gacaactact gtgaaaagct gctgccctgg ctggacaagt ccatcgagtt   1080

catcgataaa gccaagctgt ccagctgcca agtcatcgtc caccatctgg ccggcatctc   1140

ctgctgtgcc actatcgcca tcgcctacat catgaagacc atgggcatgt cctccgaaga   1200

cgcctacagg tttgtgaagg accagcgccc gtccatctcg cccaacttca acttcctggg   1260

ccagctgctg gagtaccaga gcagcccgaa gctgctggcc gccgtgcagg gcgacgcggg   1320

caccccctca ggaatgcagg agcctccccc cagccctgcg gccggggccc cactgccatg   1380

gctgccacca cctacctcag agaccgctgc caccaggagt gcggctgcca gggagggcgg   1440

cccgagcgcg ggcaggaagc ccccggcgcc ccccacggcc accagcacgc tgcagcaggg   1500

cctgcgcagc ctgcgcctct cctcggacca cctgcaggac accagccgcc tcaagccctc   1560

cttctctctg gacatcaagt cggcctacgc ccccagcagg cggcccggcg gcccgggccc   1620

agcgaccccg gcgaggcccc gaagctctct gaaagctgga cagccagcta cgcggctgcc   1680

gggccctggc cagccggcca gccccggagc ctggacgcca ccgctcgact ccctgaagcg   1740

tcctcggtgc ttcagccccg agggcgtgca agggccgggc agggtgctgt ttgcgccctt   1800

cggccgggcg ggcgccccgg aacccaacgg ctgcagcgac ctgccacggc gggaggcagc   1860

aagggctgag cccgggacgc gcggaccagc tggtcagacg agctggcccc ggattcgcac   1920

ttcaagtgct gcagctgcca gatggagttc gaggagggca tggtggaggg gcgcgcgcgc   1980

agcgaggagc tggccgccct gggcaagcag gggagcttct cgggcagcgt ggaggtcatc   2040

gagatgtcct ga                                                       2052


<210>  750
<211>  4862
<212>  DNA
<213>  Homo sapiens

<400>  750
actgcgcggc tccccgcgcc gcagctgggc accagcagca ccacggaccg cccctgtgct     60

cgcccgacgg cgccccgcgg cgctttaaga gacggcctgg cagcccagcc ccagccgccc    120

agaccggcga gaccagcctg cgggagcagc cccatggcgg agcagctggc cctggtgatt    180

gggggcacca tcggggggct gctgctgctg ctgttgatcg gggcaagctg ctgtctgtgg    240

agaaggttct gtgccaccct cacctatgag gagctgcctg ggacaccagc catggccacc    300

acagctgcct ccagtgggca gcgggacagg ccctgccagc cgcatgctag gacccaactg    360

agcaggccac cagctgtgcc attcgtggtg cccccaaccc ttcaaggccg agattgggtg    420

cccctgcaca gtggagagtg ggccgatgcc ccatgggacc cctgcccggc atcagagctg    480

ctgcctcaca cctccagcgg cggccttgga gatgcatgta tggtgggggc catcaaccca    540

gagctgtaca agttcccgga ggacaaaagt gagaccgact tccccgacgg ctgcctgggg    600

cggctgtggt tctcggtgga atatgagcag gaggctgagc ggctgctggt gggcttgatc    660

aaggcacagc acctgcaagc cccctcggag acctgcagcc ccctggtgaa gctctacctg    720

ctgcccgatg agcggcgctt cctccaatcc aagaccaaac gcaaaacctc caacccgcag    780

tttgacgagc acttcatctt tcaggtgtcc agcaagacca tcacccagag ggtgctgaag    840

ttctccgtct accacgtgga caggcagagg aagcaccagc tcctgggcca ggtgctcttc    900

cccttgaaga atgagaccct agtgggggac tgccggcgtg tcatctggag agacctggag    960

gccgagagcc tggagccccc ctcggagttt ggcgacctcc agttctgcct cagctacaac   1020

gactacctga gccgcctgac ggtggttgtg ctgcgtgcca agggcctccg gctccaggag   1080

gacagaggca ttgtcagtgt gtttgtcaaa gtgtctctga tgaaccacaa caagtttgtc   1140

aagtgcaaga agacttcagc tgtgctgggc tccatcaacc ctgtgtacaa tgagaccttc   1200

agcttcaagg ccgatgccac cgagctggat accgctagcc tcagcctgac tgtggtgcag   1260

aacatggaag gggacaagag ccagcagctg ggccgagtgg tggtgggccc ctacatgtac   1320

acccgcggca gagagctgga gcactgggac gagatgctca gcaagcccaa ggagctggtg   1380

aagcgctggc atgcgctctg ccgcaccacg gagccctgac ccttcgccca gcaccgcggt   1440

tccgctttgg gagccgacca tcctcgcagt tgcatgtgac agccacagcc acacgcatgg   1500

acgtttcatc caacagctcc ccgagctgcc agccagcccg agccaggagg acgtgagtgc   1560

tgatatgcag gagagaagag gggacaaaga agccctggcc cggtcagcgg ctctggccat   1620

acagccttcc gacacactcc ctcctcctta tctgcggggc tgcctgggct cggaatcccg   1680

gctcctggtc ctcacagccc tgatttggac cagaatctca gatgctcaga agaaagatcc   1740

tgtttagtga tgacccagct ctacctgctg aatggacctg cagggtaaac ttgggtgcct   1800

ccatctggga aagctgatga tgtgttcatg cagtcgatga ccctcactgc tttttcagcc   1860

agggtttctc tgccttctgc ctggcagaga aaacacactg ctatggggaa aatcacaggg   1920

agggcgctgt gaccagcgca ctcaggcacc aagtgtcggc atggctcact gtgctgggtg   1980

aaggcctccc cgagcattag gtcctccacg gggctgtgtc aaatgccctc ccacattgtg   2040

tcaagtctgc ccatggccca ccctccccac agtccaaaac cacacagccc tggttctcca   2100

gctgttctgc tgctgtttct gtgctctccc tgattaagag cattcagttc ctgggctctc   2160

cctttgagca ggaaatggtg aaagcatgtg gctatggtat agcccacagg gctgagattg   2220

ctgtgttgca gtattgatgt aaaatttgtt aagaaggaag tacccacaga tcactgccat   2280

caactcccca gaagttgcac tcaagctagt gagcagccct tgtgcttgtc acagttactg   2340

taacaggtag tgtgtatttg cacctggcat cgtgcagcct gcacgtcaac acgttgtttt   2400

gtgtaactag aacagcacat ggaaccacta tctctttctc ttttttcctt ctttttcttt   2460

tttttttttt tattttaatt ttttgagacg gagtttccct cttgtcaccc aggctggagt   2520

gcaatggcgt gatctcggct cactgcaccc tccacctccc aggttcaagc gattctcctg   2580

cctcagcctc ccaagtagct gggattactg gcgcccgcca ccatgcctgg ctaatttttt   2640

ttatttttag tagagacgga attttaccat gttggctagg ctggtctcaa attcctggcc   2700

tcaggtgatc cacctgcctc agcctcccaa agtgctggga ttacaggcat gagtcaccgc   2760

acccagcccg accagtatct ttttcttatg cagtgaaaca actttagcaa aagaggcaat   2820

gaatgttata ctgagtttct acctctttaa ctccacctcc aatttctgtc aatctacaaa   2880

cacaagtgtc gcctcgcagt gtttcgtatg aacagaatat cttgtgtttg ctttttgtca   2940

cttatttcac ttgcacattt tttgtttgtt tgtttgtttg tttgtttgtt ttttgagatg   3000

gagtcttgct ctgtcgccca ggctggagtg cggtggcgcg atctaggctt actgcaagct   3060

ccgcctcccg ggtttactta caccactgtc ctgcctcagc ctccggagta gctgggacta   3120

cagacacctg ccaccacgcc ctgctaattt tttgtatttt caagtagaga cggggtttca   3180

ctgtgttagc caggatggtc tcgatctcct gacctcatga tctacccgcc tcggcctccc   3240

aaagtgctgg gattacaggc gtgagccacc acgcccggcc cacttgcaca ttttcaaagt   3300

agtccgcaaa gctgtagttt ctaatagctt catagctcac atgtaatagg ggttctctgt   3360

gtgtttatag agcaggctac tacagtggaa ctgtttctgt ttcatctgac atccggatag   3420

atgccagcca cccccacatt ccaaggtgag atttctgact agcagtgact tttctagggc   3480

cgcttggaaa agttgataag tatccttttc tgcaggacag agtagactgg tatctctgac   3540

tcatccctga aaaatctaaa tggcaagaga ctagctggct ctctgctctg atggggagga   3600

ggttgttgtt tgggctgttc tctacagaca tagtcagggc aaaaagcata cgcatgcttc   3660

ccatggacca gagaaacctg gcctgggttg tctcaaatcc tgtccacaag gcaactccag   3720

aagaaagaag ccctttacat ttccataaaa cactttagaa tcagctagtc aatttccaca   3780

aaataaagtg ctagaatttg attggattta attgattatg tagaacaatt tgggggccat   3840

ttgacatcat taaaatattc aatcttccta ttcattaaca tggtatatct cttcacttta   3900

agtcttttgt atgtttctca gaactatttt tgtggttttc agtaaagtgt tcttgcacat   3960

ccttcaatag atttattctt agacgtttta tatttgttta tggctagtat atacagattc   4020

tgttgctaca aaactatgtt gaccttgtta tccagtgaga ggctttgtga cattcattta   4080

aattgtaata atttgcagat tatttttgta taatcatgtc ctctgtgaat gacagtttta   4140

tttcttcctt tcttaatctt tatgccttat ttagctcttg ccaaactgca gtggctgagc   4200

aattggacaa gataaagaaa taaaagtgat ccagatcata aagaaagaag taaaactata   4260

tctgcacatg acataatctt gtctatggaa aatcctaagg aatccacaca caaaaaaact   4320

actagagcta ataagtttgg caaggttgca agatataaaa ttggtataca aattgcagtg   4380

gctaggacct ccagcagaat gctgactata agtagtgata gtgggtattc ttgtctcatc   4440

ctcaatctca ggggtggtgg gtgtggcatg tggagagttg tcaatattca ccatgaagtt   4500

tgatggttgt tataggattt ttaatgtact cattaacata tattctcaag ctgttaaaaa   4560

gattttttta attacaaata aggttaaatt tctctcaaat acttactctg caccttttga   4620

aataatttta tttttctcct ttattctttg gatgtgatga cttatactaa ttgactgttg   4680

aatgtcaaac caaacttaac attcttgtaa tagaaaccag cagggtgtgt acacttttgt   4740

gtgtgtgcgc aggtttatac acataaacac aacaatactt ggacttattt atttaaaatt   4800

tagatttatt agagggagca tggccataaa ataaaataaa ataaaattta gatttaagtc   4860

ga                                                                  4862


<210>  751
<211>  421
<212>  PRT
<213>  Homo sapiens

<400>  751

Met Ala Glu Gln Leu Ala Leu Val Ile Gly Gly Thr Ile Gly Gly Leu 
1               5                   10                  15


Leu Leu Leu Leu Leu Ile Gly Ala Ser Cys Cys Leu Trp Arg Arg Phe 
            20                  25                  30


Cys Ala Thr Leu Thr Tyr Glu Glu Leu Pro Gly Thr Pro Ala Met Ala 
        35                  40                  45


Thr Thr Ala Ala Ser Ser Gly Gln Arg Asp Arg Pro Cys Gln Pro His 
    50                  55                  60


Ala Arg Thr Gln Leu Ser Arg Pro Pro Ala Val Pro Phe Val Val Pro 
65                  70                  75                  80


Pro Thr Leu Gln Gly Arg Asp Trp Val Pro Leu His Ser Gly Glu Trp 
                85                  90                  95


Ala Asp Ala Pro Trp Asp Pro Cys Pro Ala Ser Glu Leu Leu Pro His 
            100                 105                 110


Thr Ser Ser Gly Gly Leu Gly Asp Ala Cys Met Val Gly Ala Ile Asn 
        115                 120                 125


Pro Glu Leu Tyr Lys Phe Pro Glu Asp Lys Ser Glu Thr Asp Phe Pro 
    130                 135                 140


Asp Gly Cys Leu Gly Arg Leu Trp Phe Ser Val Glu Tyr Glu Gln Glu 
145                 150                 155                 160


Ala Glu Arg Leu Leu Val Gly Leu Ile Lys Ala Gln His Leu Gln Ala 
                165                 170                 175


Pro Ser Glu Thr Cys Ser Pro Leu Val Lys Leu Tyr Leu Leu Pro Asp 
            180                 185                 190


Glu Arg Arg Phe Leu Gln Ser Lys Thr Lys Arg Lys Thr Ser Asn Pro 
        195                 200                 205


Gln Phe Asp Glu His Phe Ile Phe Gln Val Ser Ser Lys Thr Ile Thr 
    210                 215                 220


Gln Arg Val Leu Lys Phe Ser Val Tyr His Val Asp Arg Gln Arg Lys 
225                 230                 235                 240


His Gln Leu Leu Gly Gln Val Leu Phe Pro Leu Lys Asn Glu Thr Leu 
                245                 250                 255


Val Gly Asp Cys Arg Arg Val Ile Trp Arg Asp Leu Glu Ala Glu Ser 
            260                 265                 270


Leu Glu Pro Pro Ser Glu Phe Gly Asp Leu Gln Phe Cys Leu Ser Tyr 
        275                 280                 285


Asn Asp Tyr Leu Ser Arg Leu Thr Val Val Val Leu Arg Ala Lys Gly 
    290                 295                 300


Leu Arg Leu Gln Glu Asp Arg Gly Ile Val Ser Val Phe Val Lys Val 
305                 310                 315                 320


Ser Leu Met Asn His Asn Lys Phe Val Lys Cys Lys Lys Thr Ser Ala 
                325                 330                 335


Val Leu Gly Ser Ile Asn Pro Val Tyr Asn Glu Thr Phe Ser Phe Lys 
            340                 345                 350


Ala Asp Ala Thr Glu Leu Asp Thr Ala Ser Leu Ser Leu Thr Val Val 
        355                 360                 365


Gln Asn Met Glu Gly Asp Lys Ser Gln Gln Leu Gly Arg Val Val Val 
    370                 375                 380


Gly Pro Tyr Met Tyr Thr Arg Gly Arg Glu Leu Glu His Trp Asp Glu 
385                 390                 395                 400


Met Leu Ser Lys Pro Lys Glu Leu Val Lys Arg Trp His Ala Leu Cys 
                405                 410                 415


Arg Thr Thr Glu Pro 
            420


<210>  752
<211>  1536
<212>  DNA
<213>  Homo sapiens

<400>  752
actgcgcggc tccccgcgcc gcagctgggc accagcagca ccacggaccg cccctgtgct     60

cgcccgacgg cgccccgcgg cgctttaaga gacggcctgg cagcccagcc ccagccgccc    120

agaccggcga gaccagcctg cgggagcagc cccatggcgg agcagctggc cctggtgatt    180

gggggcacca tcggggggct gctgctgctg ctgttgatcg gggcaagctg ctgtctgtgg    240

agaaggttct gtgccaccct cacctatgag gagctgcctg ggacaccagc catggccacc    300

acagctgcct ccagtgggca gcgggacagg ccctgccagc cgcatgctag gacccaactg    360

agcaggccac cagctgtgcc attcgtggtg cccccaaccc ttcaaggccg agattgggtg    420

cccctgcaca gtggagagtg ggccgatgcc ccatgggacc cctgcccggc atcagagctg    480

ctgcctcaca cctccagcgg cggccttgga gatgcatgta tggtgggggc catcaaccca    540

gagctgtaca agttcccgga ggacaaaagt gagaccgact tccccgacgg ctgcctgggg    600

cggctgtggt tctcggtgga atatgagcag gaggctgagc ggctgctggt gggcttgatc    660

aaggcacagc acctgcaagc cccctcggag acctgcagcc ccctggtgaa gctctacctg    720

ctgcccgatg agcggcgctt cctccaatcc aagaccaaac gcaaaacctc caacccgcag    780

tttgacgagc acttcatctt tcaggtgtcc agcaagacca tcacccagag ggtgctgaag    840

ttctccgtct accacgtgga caggcagagg aagcaccagc tcctgggcca ggtgctcttc    900

cccttgaaga atgagaccct agtgggggac tgccggcgtg tcatctggag agacctggag    960

gccgagagcc tggagccccc ctcggagttt ggcgacctcc agttctgcct cagctacaac   1020

gactacctga gccgcctgac ggtggttgtg ctgcgtgcca agggcctccg gctccaggag   1080

gacagaggca ttgtcagtgt gtttgtcaaa gtgtctctga tgaaccacaa caagtttgtc   1140

aagtgcaaga agacttcagc tgtgctgggc tccatcaacc ctgtgtacaa tgagaccttc   1200

agcttcaagg ccgatgccac cgagctggat accgctagcc tcagcctgac tgtggtgcag   1260

aacatggaag gggacaagca ggctactaca gtggaactgt ttctgtttca tctgacatcc   1320

ggatagatgc cagccacccc cacattccaa gattccagtt ctttgatgaa agtctctatt   1380

ccacccatca agtctgtgtc tgataacacc aatatctggg tcattagtgg ctccgttttg   1440

ttgtgtctgt tttcccctcc ttcctgtttt gtggtgtgtt tgatcactta ttgttgaatg   1500

ctaaccatta taataaattt tagtggctcc aggaaa                             1536


<210>  753
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  753

Met Ala Glu Gln Leu Ala Leu Val Ile Gly Gly Thr Ile Gly Gly Leu 
1               5                   10                  15


Leu Leu Leu Leu Leu Ile Gly Ala Ser Cys Cys Leu Trp Arg Arg Phe 
            20                  25                  30


Cys Ala Thr Leu Thr Tyr Glu Glu Leu Pro Gly Thr Pro Ala Met Ala 
        35                  40                  45


Thr Thr Ala Ala Ser Ser Gly Gln Arg Asp Arg Pro Cys Gln Pro His 
    50                  55                  60


Ala Arg Thr Gln Leu Ser Arg Pro Pro Ala Val Pro Phe Val Val Pro 
65                  70                  75                  80


Pro Thr Leu Gln Gly Arg Asp Trp Val Pro Leu His Ser Gly Glu Trp 
                85                  90                  95


Ala Asp Ala Pro Trp Asp Pro Cys Pro Ala Ser Glu Leu Leu Pro His 
            100                 105                 110


Thr Ser Ser Gly Gly Leu Gly Asp Ala Cys Met Val Gly Ala Ile Asn 
        115                 120                 125


Pro Glu Leu Tyr Lys Phe Pro Glu Asp Lys Ser Glu Thr Asp Phe Pro 
    130                 135                 140


Asp Gly Cys Leu Gly Arg Leu Trp Phe Ser Val Glu Tyr Glu Gln Glu 
145                 150                 155                 160


Ala Glu Arg Leu Leu Val Gly Leu Ile Lys Ala Gln His Leu Gln Ala 
                165                 170                 175


Pro Ser Glu Thr Cys Ser Pro Leu Val Lys Leu Tyr Leu Leu Pro Asp 
            180                 185                 190


Glu Arg Arg Phe Leu Gln Ser Lys Thr Lys Arg Lys Thr Ser Asn Pro 
        195                 200                 205


Gln Phe Asp Glu His Phe Ile Phe Gln Val Ser Ser Lys Thr Ile Thr 
    210                 215                 220


Gln Arg Val Leu Lys Phe Ser Val Tyr His Val Asp Arg Gln Arg Lys 
225                 230                 235                 240


His Gln Leu Leu Gly Gln Val Leu Phe Pro Leu Lys Asn Glu Thr Leu 
                245                 250                 255


Val Gly Asp Cys Arg Arg Val Ile Trp Arg Asp Leu Glu Ala Glu Ser 
            260                 265                 270


Leu Glu Pro Pro Ser Glu Phe Gly Asp Leu Gln Phe Cys Leu Ser Tyr 
        275                 280                 285


Asn Asp Tyr Leu Ser Arg Leu Thr Val Val Val Leu Arg Ala Lys Gly 
    290                 295                 300


Leu Arg Leu Gln Glu Asp Arg Gly Ile Val Ser Val Phe Val Lys Val 
305                 310                 315                 320


Ser Leu Met Asn His Asn Lys Phe Val Lys Cys Lys Lys Thr Ser Ala 
                325                 330                 335


Val Leu Gly Ser Ile Asn Pro Val Tyr Asn Glu Thr Phe Ser Phe Lys 
            340                 345                 350


Ala Asp Ala Thr Glu Leu Asp Thr Ala Ser Leu Ser Leu Thr Val Val 
        355                 360                 365


Gln Asn Met Glu Gly Asp Lys Gln Ala Thr Thr Val Glu Leu Phe Leu 
    370                 375                 380


Phe His Leu Thr Ser Gly 
385                 390


<210>  754
<211>  807
<212>  DNA
<213>  Homo sapiens

<400>  754
atgagaggcg gagcgcgggg agtgcgatgc ggccaccggg ggctctgggc gctgggcagg     60

ggccaggatg ccgggggtct gagcgcaggc agcgggaagg agtgggttct gaggctcagc    120

aagggggagg tgccgcccac cacgcccccc gccccaacgg gagcgcgcgg agccagcctc    180

tcaccctctc gcccgccggg gccgcgcagg cgggggaagc gctgctcctg cggccgccac    240

aggtgccagg tgccgcggcc caagatggag ccagagccga cctggcctgg gcgcgagacg    300

ccgcccgccg ccgtcggccc ggcccgcgga gcaagcgccg ggtacaggga ggggccagcg    360

gggcagctgg caccggggcg gcgggagggg cggcgggcgg agacctcgct cacctgggcc    420

cgtgccactc tggagcctgc caccgccccg ccgcggcccg ggatctgcgt ccgcgcgccc    480

ccacccctcc ttcccgaccc ctcctcaggc cgggtcccca ctgtcctcgg tcttttcggc    540

cccgcccgca ccacgaccgc ctgttctcca ggctgcccag cgaaccccca agactcccac    600

ttccccgacg caaccccacc gtcccgggtg tataggcgca gctccccacg attctccggc    660

cccagaccca gcccctcaag tccacctcct cgtagcccca ccccctcgct ccagtgcccc    720

tcgctccagt tccccctccg caccacgccc cgcattgagg tctccgcgcc ggcggctacc    780

cctttcctct cgccttctcc atcctag                                        807


<210>  755
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  755

Met Arg Gly Gly Ala Arg Gly Val Arg Cys Gly His Arg Gly Leu Trp 
1               5                   10                  15


Ala Leu Gly Arg Gly Gln Asp Ala Gly Gly Leu Ser Ala Gly Ser Gly 
            20                  25                  30


Lys Glu Trp Val Leu Arg Leu Ser Lys Gly Glu Val Pro Pro Thr Thr 
        35                  40                  45


Pro Pro Ala Pro Thr Gly Ala Arg Gly Ala Ser Leu Ser Pro Ser Arg 
    50                  55                  60


Pro Pro Gly Pro Arg Arg Arg Gly Lys Arg Cys Ser Cys Gly Arg His 
65                  70                  75                  80


Arg Cys Gln Val Pro Arg Pro Lys Met Glu Pro Glu Pro Thr Trp Pro 
                85                  90                  95


Gly Arg Glu Thr Pro Pro Ala Ala Val Gly Pro Ala Arg Gly Ala Ser 
            100                 105                 110


Ala Gly Tyr Arg Glu Gly Pro Ala Gly Gln Leu Ala Pro Gly Arg Arg 
        115                 120                 125


Glu Gly Arg Arg Ala Glu Thr Ser Leu Thr Trp Ala Arg Ala Thr Leu 
    130                 135                 140


Glu Pro Ala Thr Ala Pro Pro Arg Pro Gly Ile Cys Val Arg Ala Pro 
145                 150                 155                 160


Pro Pro Leu Leu Pro Asp Pro Ser Ser Gly Arg Val Pro Thr Val Leu 
                165                 170                 175


Gly Leu Phe Gly Pro Ala Arg Thr Thr Thr Ala Cys Ser Pro Gly Cys 
            180                 185                 190


Pro Ala Asn Pro Gln Asp Ser His Phe Pro Asp Ala Thr Pro Pro Ser 
        195                 200                 205


Arg Val Tyr Arg Arg Ser Ser Pro Arg Phe Ser Gly Pro Arg Pro Ser 
    210                 215                 220


Pro Ser Ser Pro Pro Pro Arg Ser Pro Thr Pro Ser Leu Gln Cys Pro 
225                 230                 235                 240


Ser Leu Gln Phe Pro Leu Arg Thr Thr Pro Arg Ile Glu Val Ser Ala 
                245                 250                 255


Pro Ala Ala Thr Pro Phe Leu Ser Pro Ser Pro Ser 
            260                 265


<210>  756
<211>  1823
<212>  DNA
<213>  Homo sapiens

<400>  756
gcctttgctc ctgagaagtt gctgacaggt ggaacctgag gcagcaggac agcctggcat     60

tggccacggg acatcggcca caaccatagc aacttcggca tcaaatgggg caggagagag    120

aacattaagg cagccatgag ctccagccgc cccgagccgg gtccctgggc acccctgagc    180

ccccgccttc agcccctgtc ccagagctct tccagcctgc tgggtgaagg ccgggaacag    240

aggccagagc tccgcaagac tgccagcagc accgtgtggc aggcccagct gggcgaggcc    300

agcaccagac cccaggcccc ggaggaagag gggaacccgc ctgagagcat gaagccagca    360

cgggcctctg gccccaaggc gcgacccagt gctggaggcc actggtggag cagcactgtg    420

ggcaatgtgt ccaccatggg cggcagtgac ctgtgtcgcc tgcgggcccc tagtgctgct    480

gctatgcaga ggagccattc agacctggtc cgtagcaccc agatgcgggg acacagtggt    540

gctcggaagg ccagtctcag ctgctcagcc cttggcagca gccctgtcca cagggctcag    600

ctgcagccag gtggtacttc tggccagggt ggccaggccc ctgcaggcct ggaaagggac    660

ctggctcctg aggatgagac ttctaactca gcctggatgc tgggggcgag tcagttgtca    720

gtgccaccac tagacctggg ggacacaact gcccacagca gcagtgccca ggctgagccc    780

aaagctgctg aacagctggc taccaccacc tgccatgctc tgcccccagc tgctctactc    840

tgtggcatga gggaggtgag ggctggtggc tgctgccatg ccctacctgc cacagggatc    900

ctggcctttc ccaaactagt ggcgtcagtg agcgagtctg ggctgcaggc tcagcatggg    960

gtgaagatcc actgtaggtt gtctgggggg ctccctgggc attcccattg ctgtgcccac   1020

ctttggggtc ccgctgggtt agtcccagag cctggctcta ggaccaaaga tgtgtggacc   1080

atgacctcag ccaatgactt ggcccctgca gaggcatccc cgctgtcagc ccaggatgct   1140

ggtgtgcagg cggccccagt ggcggcctgc aaggctgtgg ccaccagtcc gtccctggaa   1200

gcgcctgcag ccctgcatgt gttcccagag gtaactctgg ggtccagcct ggaggaggtg   1260

ccgtcccctg tgcgggatgt gcgatgggat gctgagggca tgacatggga ggtgtacgga   1320

gctgcggtgg acctggaggt gctcggtgtg gccatccaga agcacctgga gatgcagttt   1380

gagcagctgc agcgggcgcc cgccagcgag gacagcctgt ctgtggaggg ccggaggggg   1440

ccactgcggg ctgtcatgca gtccctgcgg cgccccagct gctgcggctg ctccggcgcg   1500

gcccccgagt gaggagctgt ggcccttgga gctggcctgg gcccactgac ttagtcctag   1560

acctgggcca gggacggtgg gggctccgtg ccccctggac ccaccggcag ctgggcacat   1620

ctctcacctg aatattggct gcctccagac cacaggactg cagcctgggg cttccggccc   1680

tacacagctg ggctgttttc ttaagggctt gatttccaag ggccacatct ctgcaccttc   1740

cgggctctga actttgagac agggctttag cactgtgcag aggggagatc ctgagttttc   1800

tgtaaaaaat gaccttttgt tca                                           1823


<210>  757
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  757

Met Ser Ser Ser Arg Pro Glu Pro Gly Pro Trp Ala Pro Leu Ser Pro 
1               5                   10                  15


Arg Leu Gln Pro Leu Ser Gln Ser Ser Ser Ser Leu Leu Gly Glu Gly 
            20                  25                  30


Arg Glu Gln Arg Pro Glu Leu Arg Lys Thr Ala Ser Ser Thr Val Trp 
        35                  40                  45


Gln Ala Gln Leu Gly Glu Ala Ser Thr Arg Pro Gln Ala Pro Glu Glu 
    50                  55                  60


Glu Gly Asn Pro Pro Glu Ser Met Lys Pro Ala Arg Ala Ser Gly Pro 
65                  70                  75                  80


Lys Ala Arg Pro Ser Ala Gly Gly His Trp Trp Ser Ser Thr Val Gly 
                85                  90                  95


Asn Val Ser Thr Met Gly Gly Ser Asp Leu Cys Arg Leu Arg Ala Pro 
            100                 105                 110


Ser Ala Ala Ala Met Gln Arg Ser His Ser Asp Leu Val Arg Ser Thr 
        115                 120                 125


Gln Met Arg Gly His Ser Gly Ala Arg Lys Ala Ser Leu Ser Cys Ser 
    130                 135                 140


Ala Leu Gly Ser Ser Pro Val His Arg Ala Gln Leu Gln Pro Gly Gly 
145                 150                 155                 160


Thr Ser Gly Gln Gly Gly Gln Ala Pro Ala Gly Leu Glu Arg Asp Leu 
                165                 170                 175


Ala Pro Glu Asp Glu Thr Ser Asn Ser Ala Trp Met Leu Gly Ala Ser 
            180                 185                 190


Gln Leu Ser Val Pro Pro Leu Asp Leu Gly Asp Thr Thr Ala His Ser 
        195                 200                 205


Ser Ser Ala Gln Ala Glu Pro Lys Ala Ala Glu Gln Leu Ala Thr Thr 
    210                 215                 220


Thr Cys His Ala Leu Pro Pro Ala Ala Leu Leu Cys Gly Met Arg Glu 
225                 230                 235                 240


Val Arg Ala Gly Gly Cys Cys His Ala Leu Pro Ala Thr Gly Ile Leu 
                245                 250                 255


Ala Phe Pro Lys Leu Val Ala Ser Val Ser Glu Ser Gly Leu Gln Ala 
            260                 265                 270


Gln His Gly Val Lys Ile His Cys Arg Leu Ser Gly Gly Leu Pro Gly 
        275                 280                 285


His Ser His Cys Cys Ala His Leu Trp Gly Pro Ala Gly Leu Val Pro 
    290                 295                 300


Glu Pro Gly Ser Arg Thr Lys Asp Val Trp Thr Met Thr Ser Ala Asn 
305                 310                 315                 320


Asp Leu Ala Pro Ala Glu Ala Ser Pro Leu Ser Ala Gln Asp Ala Gly 
                325                 330                 335


Val Gln Ala Ala Pro Val Ala Ala Cys Lys Ala Val Ala Thr Ser Pro 
            340                 345                 350


Ser Leu Glu Ala Pro Ala Ala Leu His Val Phe Pro Glu Val Thr Leu 
        355                 360                 365


Gly Ser Ser Leu Glu Glu Val Pro Ser Pro Val Arg Asp Val Arg Trp 
    370                 375                 380


Asp Ala Glu Gly Met Thr Trp Glu Val Tyr Gly Ala Ala Val Asp Leu 
385                 390                 395                 400


Glu Val Leu Gly Val Ala Ile Gln Lys His Leu Glu Met Gln Phe Glu 
                405                 410                 415


Gln Leu Gln Arg Ala Pro Ala Ser Glu Asp Ser Leu Ser Val Glu Gly 
            420                 425                 430


Arg Arg Gly Pro Leu Arg Ala Val Met Gln Ser Leu Arg Arg Pro Ser 
        435                 440                 445


Cys Cys Gly Cys Ser Gly Ala Ala Pro Glu 
    450                 455


<210>  758
<211>  1956
<212>  DNA
<213>  Homo sapiens

<400>  758
gggcacagga gtgcggccgg gggcggggcc gagtgggccc cggtacgaac cctccgggaa     60

gccgggcgcg ctgcctgccc ttggcccggg gcgcagagcg tcacactgga tctggggagc    120

atcctacccc cactgtggac ctcagtctcc tcacctgaga catgggcggc cccatccgca    180

ccctgtaagc cgcaagccaa ggagattcct ggcccccatc ctggattcac ttaactacat    240

ctcctggtgg aagggccctg ggatctgcac tttcaacatg cttctagaat gattctgatg    300

tttactgaag gttgagaact gcaaccctgt gggattaata atgactagag aatctgagag    360

gcgtcatccc tcaagtgtat cacttagttc aagagtcctg gaatcttttc acatccacta    420

tgaacacctc tcacctcctg gccttgctgc tcccaaaatc tccacaaggt gaaaacagaa    480

gcaaacccct gggcacccca tacaacttct ctgaacattg ccaggattcc gtggacgtga    540

tggtcttcat cgtcacttcc tacagcattg agactgtcgt gggggtcctg ggtaacctct    600

gcctgatgtg tgtgactgtg aggcagaagg agaaagccaa cgtgaccaac ctgcttatcg    660

ccaacctggc cttctctgac ttcctcatgt gcctcctctg ccagccgctg accgccgtct    720

acaccatcat ggactactgg atctttggag agaccctctg caagatgtcg gccttcatcc    780

agtgcatgtc ggtgacggtc tccatcctct cgctcgtcct cgtggccctg gagaggcatc    840

agctcatcat caacccaaca ggctggaagc ccagcatctc acaggcctac ctggggattg    900

tgctcatctg ggtcattgcc tgtgtcctct ccctgccctt cctggccaac agcatcctgg    960

agaatgtctt ccacaagaac cactccaagg ctctggagtt cctggcggat aaggtggtct   1020

gtaccgagtc ctggccactg gctcaccacc gcaccatcta caccaccttc ctgctcctct   1080

tccagtactg cctcccactg ggcttcatct tggtctgtta tgcacgcatc taccggcgcc   1140

tgcagaggca ggggcgcgtg tttcacaagg gcacctacag cttgcgagct gggcacatga   1200

agcaggtcaa tgtggtgctg gtggtgatgg tggtggcctt tgccgtgctc tggctgcctc   1260

tgcatgtgtt caacagcctg gaagactggc accatgaggc catccccatc tgccacggga   1320

acctcatctt cttagtgtgc cacttgcttg ccatggcctc cacctgcgtc aacccattca   1380

tctatggctt tctcaacacc aacttcaaga aggagatcaa ggccctggtg ctgacttgcc   1440

agcagagcgc ccccctggag gagtcggagc atctgcccct gtccacagta catacggaag   1500

tctccaaagg gtccctgagg ctaagtggca ggtccaatcc catttaacca ggtctaggtc   1560

ttctccctgc catgtccctt gccaggctct tccacttagc taagtgggca cactgcaagc   1620

tggggtggca ccccagcatt cctggctttc tggggtccag ataggctggc aagagctgtt   1680

tttgcatcca tttgcatcgt gaagactggc attttgatac ttcagctgtt tgttcctggg   1740

agaattctga gcacagattc cagaggtcac agtaagcctt gcagcttgag ctgaaagatg   1800

ccagagccgg agatgtctgc tggcagcagg cagggttcat tctggtgaca cagcaacaga   1860

tgcctggcct gggaacccag ggatttcacc tccaccagtg agaccacggg gccactgtgg   1920

ggtgagggaa ggagcgcttg gagtcagagc tctaga                             1956


<210>  759
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  759

Met Asn Thr Ser His Leu Leu Ala Leu Leu Leu Pro Lys Ser Pro Gln 
1               5                   10                  15


Gly Glu Asn Arg Ser Lys Pro Leu Gly Thr Pro Tyr Asn Phe Ser Glu 
            20                  25                  30


His Cys Gln Asp Ser Val Asp Val Met Val Phe Ile Val Thr Ser Tyr 
        35                  40                  45


Ser Ile Glu Thr Val Val Gly Val Leu Gly Asn Leu Cys Leu Met Cys 
    50                  55                  60


Val Thr Val Arg Gln Lys Glu Lys Ala Asn Val Thr Asn Leu Leu Ile 
65                  70                  75                  80


Ala Asn Leu Ala Phe Ser Asp Phe Leu Met Cys Leu Leu Cys Gln Pro 
                85                  90                  95


Leu Thr Ala Val Tyr Thr Ile Met Asp Tyr Trp Ile Phe Gly Glu Thr 
            100                 105                 110


Leu Cys Lys Met Ser Ala Phe Ile Gln Cys Met Ser Val Thr Val Ser 
        115                 120                 125


Ile Leu Ser Leu Val Leu Val Ala Leu Glu Arg His Gln Leu Ile Ile 
    130                 135                 140


Asn Pro Thr Gly Trp Lys Pro Ser Ile Ser Gln Ala Tyr Leu Gly Ile 
145                 150                 155                 160


Val Leu Ile Trp Val Ile Ala Cys Val Leu Ser Leu Pro Phe Leu Ala 
                165                 170                 175


Asn Ser Ile Leu Glu Asn Val Phe His Lys Asn His Ser Lys Ala Leu 
            180                 185                 190


Glu Phe Leu Ala Asp Lys Val Val Cys Thr Glu Ser Trp Pro Leu Ala 
        195                 200                 205


His His Arg Thr Ile Tyr Thr Thr Phe Leu Leu Leu Phe Gln Tyr Cys 
    210                 215                 220


Leu Pro Leu Gly Phe Ile Leu Val Cys Tyr Ala Arg Ile Tyr Arg Arg 
225                 230                 235                 240


Leu Gln Arg Gln Gly Arg Val Phe His Lys Gly Thr Tyr Ser Leu Arg 
                245                 250                 255


Ala Gly His Met Lys Gln Val Asn Val Val Leu Val Val Met Val Val 
            260                 265                 270


Ala Phe Ala Val Leu Trp Leu Pro Leu His Val Phe Asn Ser Leu Glu 
        275                 280                 285


Asp Trp His His Glu Ala Ile Pro Ile Cys His Gly Asn Leu Ile Phe 
    290                 295                 300


Leu Val Cys His Leu Leu Ala Met Ala Ser Thr Cys Val Asn Pro Phe 
305                 310                 315                 320


Ile Tyr Gly Phe Leu Asn Thr Asn Phe Lys Lys Glu Ile Lys Ala Leu 
                325                 330                 335


Val Leu Thr Cys Gln Gln Ser Ala Pro Leu Glu Glu Ser Glu His Leu 
            340                 345                 350


Pro Leu Ser Thr Val His Thr Glu Val Ser Lys Gly Ser Leu Arg Leu 
        355                 360                 365


Ser Gly Arg Ser Asn Pro Ile 
    370                 375


<210>  760
<211>  362
<212>  DNA
<213>  Homo sapiens

<400>  760
tcagcatcct agttcgccac tgtctgctgc cacacgatgc tgggaggcct ggggaagctg     60

gctgccgagg gcctggccca ccgcaccgag aaggccaccg agggagccat tcatgccgtg    120

gaggaagtgg tgaaggaggt ggtgggacat gccaaggaga ctggagagaa agccattgct    180

gaagccataa agaaagccca ggagtcaggg gacaaaaaga tgaaggaaat caccgagaca    240

gtgaccaaca cagtcacaaa tgccatcacc catgcagcag aaagtctgga caaacttgga    300

cagtgagtgc acctgctacc acggcccttc cccagtctca ataaaaagcc atgacatgtg    360

ta                                                                   362


<210>  761
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  761

Met Leu Gly Gly Leu Gly Lys Leu Ala Ala Glu Gly Leu Ala His Arg 
1               5                   10                  15


Thr Glu Lys Ala Thr Glu Gly Ala Ile His Ala Val Glu Glu Val Val 
            20                  25                  30


Lys Glu Val Val Gly His Ala Lys Glu Thr Gly Glu Lys Ala Ile Ala 
        35                  40                  45


Glu Ala Ile Lys Lys Ala Gln Glu Ser Gly Asp Lys Lys Met Lys Glu 
    50                  55                  60


Ile Thr Glu Thr Val Thr Asn Thr Val Thr Asn Ala Ile Thr His Ala 
65                  70                  75                  80


Ala Glu Ser Leu Asp Lys Leu Gly Gln 
                85


<210>  762
<211>  3817
<212>  DNA
<213>  Homo sapiens

<400>  762
gtgaacaggt ttggtgccgc gggctggggt tagagttact tgttattggt aaatagccac     60

tatggagact aaggaccaga agaaacacag aaagaaaaac ggtggaccca aagctgcaaa    120

gaaaaagaag tggcatctgc aggatctcca gctaggagac taagaaaatg cccagaagag    180

aaatgccaat gcttttgcag ttcagtctgc tgtgtggatg tctcgatcct ttcacaggac    240

tctggatttg aagacacaaa agcatcatat tccagtggtt gatggaactc cactagagcc    300

gccaccaata ccggtagtgg tgacggggcc tccaaagttg gaaagagcac tttgatataa    360

tgcctcattc ggaacttcac ctggcagaag ttcaccgaga tcagaggccc tgtgacgatc    420

gtgtcaggta aaaagcgcag actcaccatt attgaatgtg ggtgtgacat taacatgatg    480

attgatctgg ctaaagtagc agatctggta ctgatgctta tagatgccag ctttgggttt    540

gaaatggaaa tgtttgagtt tctaaacatc tgtcaagcac atggctttcc taaaattctg    600

ggagttctca cccacctcga ctccttcaag cataacaagc aactgaagaa gacaaagaag    660

cgattaaaac acaggttctg gacagaagtt taccaggttg ccaaactgtt ctacctttct    720

ggaatggtgc atggagaata tcaaaaccaa gaaatccaca atctgggcca ttttattaca    780

gttatgaagt ttaggcctct catggcaaac ttttcaccct tatatcctgg cagacaggat    840

ggaagatttg acaaacccgg aggatatcca aacaaacatc aaatgtgacc ggcaggtgtc    900

actttatggt tatttaagag gagcacactt caaagataaa agccaaattc acatgccagg    960

acaaggtggg gctcacccat gagctggtcc agagtctcat ctccacctac tccaccattg   1020

atgccaagat ggcttcaagt cgagtgacgc tgctttccaa ttccaaacca cttgggtcag   1080

aggctataga taatcaaggg gacgagttct cactatgttg cctaggctgg tctcgaactc   1140

ctgggctcaa gcaatcctcc cgacttggcc tcccaaaatc ctgggattac atatgtgagc   1200

cactatgcct ggcctgttat tcctgtattc taacttatcc atcccttatg tgtcagagat   1260

ggctttggat tccctgttct gtgtgctcct gtctggctcc tgaacccagc tggagaggtg   1320

tgtcaatccc aactggtgaa gtactgagag gaagctacac aaaaggcagc aaggtactag   1380

tgagtggtgt cattgagcaa acacaaagtc gggctcatcc aaggatgaga ttttgccaga   1440

gaaaggatga gcagcaagtc agggagctta agcgtcagcc tcgagtttga ccagcagcag   1500

gggtcggtgt gtccctctga atctgagatc tatgaggcag gagctgagga caggatggca   1560

ggagcgccca tggctgctgc tgtacagcct gctgaggtga ctgttgaagt tggtgaggac   1620

ctccacatgc accaggttcg tgaccgggag atgcctgaag ctttggagtt taacctttct   1680

gccaatccag aggcaagcac aatattccag aggaactctc aaacagatgc tttggagttt   1740

aactcttctg ccaatccaga ggcaagcaca atattccaga ggaactctca aacagatgtt   1800

gtagaaataa gaagaagcaa ctgtacaaac catgtatcta ctgagcgttt cagtcaacaa   1860

tacagctcgt gttcgacaat attccttgat gacagcacag ccatccagca ttatcttaca   1920

atgacaataa tatctgtgac cttggagata cctcatcata tcacacaaag agatgcagat   1980

agatctttga gcatacctga tgaacagtta cactcatttg cggtttccac cgtgcacatt   2040

atgaagaaaa gaaatggagg tgggagttta aataactatt cctcctccat tccaccgact   2100

cccagcacca gccaggagga ccctcagttc agtgttcctc ccactgccaa cacacccacc   2160

cccgtttgca agctgtccat gcgctggtcc aacctgttta catctgagaa agggagtgac   2220

ccagacaaag agaggaaagc cccggagaat catgctgaca ccatcgggag cggcagagcc   2280

atccccatta aacagggcat gctcttaaag cgaagtggaa aatggctgaa gacatggaaa   2340

aagaaatacg tcaccctgtg ttccaatggc gtgctcacct attattcaag cttaggtgat   2400

tatatgaaga atattcataa aaaagagatt gaccttcgga catctaccat caaagtccca   2460

ggaaagtggc catccctagc cacatcagcc tgtgcaccca tctccagctc taaaagcaat   2520

ggcctatcca aggacatgga caccgggctg ggtgactcca tatgcttcag ccccggtatc   2580

tccagcacca ccagccccaa gctcaacccg cccccctctc ctcatgccaa taaaaagaaa   2640

cacctaaaga agaaaagcac caacaacttt atgattgtgt ctgccactgg ccaaacgtgg   2700

cactttgaag ccacgacgta tgaggagcgg gatgcctggg tccaagccat ccagagccag   2760

atcctggcca gcctgcagtc atgcaagagc agtaaaagca agtcccagct gaccagccag   2820

agtgaggcca tggccctgca gtcgatccaa aacatgcgtg ggaacgccca ctgtgtggac   2880

tgtgagaccc agaatcctaa gtgggccagt ttgaacttgg gagtcctcat gtgtattgaa   2940

tgctcaggta tccaccgcag ttttggcacc cgcctttccc gtgtgcgatc tctggagctg   3000

gatgactggc cagttgagct caggaaggtt atgtcatcta ttggcaatga gctagccaac   3060

agcatctggg aagggagcag ccaggggcag acaaaaccct caataaagtc cacgagggaa   3120

gagaaggaat ggtggatccg ttccaaatat gaggagaagc tctttctggc cccactaccc   3180

tgcactgagc tgtccctggg ccagcagctg ctgcgggcca ccactgatga ggacctgcag   3240

acagccatcc tgctgctggc acatggctcc cgtgaggagg tgaacgagac ctgtggggag   3300

ggagacggct gcacggcact ccatctggcc tgccgcaagg ggaatgtggt cctggagcag   3360

ctcctgacgg ggtggacgtc atggcccgag atgcccacgg gaacacagcg ctgacctacg   3420

cccggcaggc ctccagccag gagtgcatca acgtgcttct gcagtacggc tgccccgacg   3480

agtgcgtgta gtatctgttt tatttgactg cagtctcctt ggtgcaaaaa caaaatggga   3540

aaaataagga taactcagaa tttcaaaagg aaatcacaaa ttcagctagt aatagcattt   3600

tcagtacttt tcgtaaacta agtaaataca caaaatgttg atttttctga ccataagaca   3660

tattttatgt ccttttgcca aggtggatgt gttagtctca ggccctcctg gccacattgc   3720

ccaagtcaca caggcttctg tattatgtat ttagataaaa tgtgtgaaaa tatatttgaa   3780

aaaaaatttc ataaatgtgc attgattttt gtacaca                            3817


<210>  763
<211>  2136
<212>  DNA
<213>  Homo sapiens

<400>  763
ttaaatttca tttatttctt tatgaagaca tgatgtattt gttcactgaa caagggtaga     60

aactgcttaa ccatccccaa tttcatttct ctctgttatg ctataaatta gatgagttac    120

ctctgctaag gttacattct atggttaagt tactttttat tcatctcaag tgtcaacatc    180

accagtacct atttctgcaa ggatggaaat attctatatc tgtacttttc agccatttag    240

ccattagcca catgtggtta cttaaaatgt acttcagaga aactgaaaaa atgaattctt    300

aattaatttc attctaactc taaatagtca catgtggcta ccatactgga cagctcagac    360

ctagacatcg actggactaa cgaagtggtt tcctaactta aaccagaact taaatttcaa    420

taaaaaattt aaaacgtttt tatgaacttc caataggatc gcagtattac ttttagtacc    480

tgttgactct aaaacttcta aattacagct catctacata catttgaaaa atagcaatat    540

ctgtatgtgt gagatatgac tggttttaga tgatgcctgg agaccccatg gacttacaga    600

gacccttcca gtgatttctg aggtacctgg gaatctgtgg ccaataaatt ggtagtcact    660

gaatctgtga gtttttttgg aatatcgggc tgcataaaat ctgacagctt gattgagaaa    720

aagcggggca gggtaccatt tcattcagtt aaggtcctgt attcattccg tttaataaat    780

gtttgtgtct gtctatgatg tgctagccac tgtgccagaa aatggatata gctatggtct    840

gattggcaga ggaaatccaa actagtatct tccgtgccat gcaataaggg ctacattgca    900

aggctgcaga gggtgctact ggagcacaga agtgagtcag aggcttctca cagacacaca    960

cacgagcgga aacagaaagt ctttatatat caccatatgt caaggaacac tggccgggag   1020

ttaggagagc tgggcactag gaacgctttg aaactgaata gctgtgtgat ttcagaggtt   1080

atattgcttc tctactatat tttactgccg aacttgtact gtttctctcc cttttcttct   1140

tggtgggaaa agcacaattt ggggtcaaca gattcggctc aggtctaagt cgcctgccgg   1200

gaccacgtcg ccaggaaacg acgtctcccc gacaccttcc ctcccagtcc gggctctctg   1260

cagggattca tcccgtcact ctcccaacga cccccgggca cacctcaggc agatgcgaaa   1320

tatgccgctc ctcgggagca aagatgaccc ggaggaccgg gggaggacct tcccatgcgc   1380

acgactcgcg atcttcccag tgccccagag ccacggaccc aaccgccgcc taccccagcc   1440

cgcggcacca aacctgttca caactgcgac tccttaggtc cgcttggaca ccgccggaaa   1500

cggaaattca ccctcgcgcc gactcgccgg agggaaacaa aaaggcagaa aaaaagggac   1560

cgccgcctgg atgactttca ggggacagct ggaagaaaga ctcgtcaacg gccgagtgct   1620

ggcgccggcg ccgtctgcgc agtgcgttcc accgggtccg cgtccctccc gattcagccc   1680

caccccgccc tcggaatccg ctgcctcagc tcctgctgtg gcactcccca gcagcttgca   1740

cctcgctcgc ggagtccttg ctgaaggcca gggcagctgt gcggcctggc gcgggttact   1800

tgatgccgtg caaaagccag gagacacatt tggttctggc cgccccggag tcaccgtgcc   1860

cggggcgaat ggactatggc tggattggga gtccacttcc tcctctgtaa agatgacaga   1920

cgagggagat ctcgcgttct gggggtgccc tatagccctc ttttggccag aagcggtgga   1980

tcacgcctgt aatcccagcc ttttgggagg ccgaggcagg aggattgctt gagcccagga   2040

gttcaagacc aatctgggca acatagggag gctacatctc tcaaaaaata aataaataaa   2100

taaataaata aataaataaa taaataaata aataaa                             2136


<210>  764
<211>  2061
<212>  DNA
<213>  Homo sapiens

<400>  764
tttttttacg ggagggagct aattggattt taagtctaga tctttgtttt caattcctca     60

acatattcta taaataagac caaattatag tagaaggaga gtaaataagc tattatcttt    120

ttaaagtggt gaagagcact gattaaatat atattagagc cccagccccc gccccagctg    180

cgcgggcccc cgcctggccc atggactgca cagccgagcg ggcgccttga gcgcggtgcg    240

ggtcctcgga gcacccccga ggtgagcgca agcaaggtcc ggcatcatgt gctaggttat    300

tcccagtgcg aggccacact tgggccgtcg gagcagcccc tcctcacttc aggggtcacc    360

ctccccaaga cccattgccc catcatggcc ggggaccggc tccccaggaa ggtgatggac    420

gccaagaagc tggccagcct gctgcggggc gggcctgggg gggcctggtc atcgacagtc    480

actccttcct ggagtacaac agctggcatg tgctcagctc cgtcaacatc tgctgctcca    540

agctggtgaa gtggcggttg cagaagggca aggtgaccat tgtggagttc atccagccgg    600

ccgcacgcag ccaggtggag gccactgagc cacaggacgt ggtggtctat gaccagagca    660

cgcggccgca gacagcttcc tctccatcct gctgagcaag ctggatggct gcttccacag    720

cgtggccggc tgcttccaca gcatggccat catcacgggg ggcttcgcca ccttctcctc    780

ctgcttcccc gacctctgcg agggcgagcc tgctgccctg ctacccatga gcctctccca    840

gtcctgcctg ctcgtgccca gcgtgggcct gaccctcatc ctgcctcacc tctacctggg    900

ctcgcaggaa gacgtcctga acaaggatct gatgacgcag aatggaataa gctacgtcct    960

ctatgccagc aactcctgcc ccaagcctga cttcatctac cagagccact tcttgcgggt   1020

ccccatcaac gacaactact gtgaaaagct gctgccctgg ctggacaagt ccatcgagtt   1080

cgtcgataaa gccaagctgt ccagctgcca agtcatcgtc caccgtctgg ccggcatctc   1140

ctgctgtgcc actatcgcca tcgcctacat catgaagacc atgggcatgt cctccgaaga   1200

cgcctacagg tttgtgaagg accagcgccc gtccatctcg cccaacttca acttcctggg   1260

ccagctgctg gaggaccaga gcagcccgaa gctgctggcc gccgtgcagg gcgacgcggg   1320

caccccctca ggaatgcagg agcctccccc cagccctgcg gccggggccc cactgccatg   1380

gctgccacca cctacctcag agaccgctgc caccaggagt gcggctgcca gggagggcgg   1440

cccgagcgcg ggcaggaagc ccccggcgcc ccccacggcc accagcacgc tgcagcaggg   1500

cctgcgcagc ctgcgcctct cctcggacca cctgcaggac accagccgcc tcaagccctc   1560

cttctctctg gacatcaagt cggcctacgc ccccagcagg cggcccggcg gcccgggccc   1620

agcgaccccg gcgaggcccc gaagctctct gaaagctgga cagccagtcg gggccattac   1680

gcggctgccg ggccctggcc agccggccag ccccggagcc tggacgccac cgctcgactc   1740

cctgaagcgt cctcggtgct tcagccccga gggcgtgcaa gggccgggca gggtgctgtt   1800

tgcgcccttc ggccgggcgg gcgccccgga acccaacggc tgcagcgacc tgccacggcg   1860

ggaggcagca agggctgagc ccgggacgcg cggaccagct ggtcagacga gctggccccg   1920

gattcgcact tcaagtgctg cagctgccag atggagttcg aggagggcat ggtggagggg   1980

cgcgcgcgcg gcgaggagct ggccgccctg ggcaagcagg ggagcttctc gggcagcgtg   2040

gaggtcatcg agatgtcctg a                                             2061


<210>  765
<211>  3497
<212>  DNA
<213>  Homo sapiens

<400>  765
atgagtggag gatctcaagt ccacattttt tggggtgctc cagttgctcc actgaaaatg     60

acagtatcag aagacacagc ttctttaatg tctgttgctg acccctggaa aaaaattcag    120

cttttataca gtcaacattc tttatatctg aaggatgaaa aacagcacaa aaatcttgaa    180

aactatgaag tcccagattc tattggttct ccagatcttt gtggtcattt cttagcaaac    240

tgtatgaata gacatgttca tgtgaaagat gactttgtac gttctgtttc tgaaacacag    300

aatatagaat cccagaagat tcactcctct agactgagtg gcataactag ctctaatatg    360

caaatatgtg gatttaaaag cacagttccg catttaaccg aagaagaaaa gtatcaaagc    420

ttctcagtga aaataaaatt agagatgaac agcctaaaca tcagccagat atatgtggtc    480

agaactttaa cacaaatttg tttcagttgg gccataaatg tgcagctgtg ttggatttgg    540

tttgtagtac tgaaaaaatt aatatagggc ctgaagtggt acaaagagag tgtgtgccaa    600

cagaatatca tgaaatacaa aaccagcgtt tgggattatt ttcctcgaac tcagtagata    660

agtcaaggtc tgaagcagca gttaagaagg tctcagacct taaaatatca actgataaag    720

aatttctcag tataattacc tccagccagg ttgctttttt tagctcaaaa gaaagataaa    780

aggcggagtc ctgtaaataa agggaatgta aacatggaga ctgaaccaaa ggcaagttac    840

ggggagataa gaatacctga agagaattcg attcagcttg atggttttac agaagcatat    900

gaaagtggac aaaaccaagc atattccctt gaacttttta gtcctgtttg tcctaaaaca    960

gaaaatagcc gcattcacat aaactctgat aaaggtcttg aagaacatac aggatctcaa   1020

gaacttttca gttctgaaga tgaactgcca ccaaatgaga tacgtattga gttgtgtagc   1080

tcaggaatac tgtgttccca actaaatacc ttccacaaaa gtgctattaa aagaagctgt   1140

acctctgaag ataaagtggc ccagtctgaa gctctatcta gagtccttca agtagctaag   1200

aaaatgaagt tgatttctaa tggaggagat tctgctgtag aaatggatcg gagaaatgtg   1260

tctgaattta agagtattaa aaaaatcatt aataaaaaac tgtgattcta aaagccagaa   1320

gtataattgt ttagtcatgg tgctatctcc atgccatgtg aaggaaataa acataaaatt   1380

cggaccaaat tctggctcta aagtgccttt agcaacagtt acagtaagtg atcaatcaga   1440

aactaagaag aaggtttttc tgtggaggac tgcagcattt tgggcattta cagtgtttct   1500

tggagatata attttactca cggatgttgt tattcatgag gaccaatgga ttggtgagac   1560

agtactacaa tcaacattta gcagtcagtt attaaatctt gggagttatt catctattca   1620

gcctgaagaa tattccagtg tagttagtga cgttgtactt caagacttac tggcatatgt   1680

gtcctcaaaa cattcctacc tcagagatct tcctccgaga cagcctcaga gggtgaacag   1740

tatagacttt gtagaattgg agcaccttca acctgatgtg ttagtccacg cagtactaag   1800

agttgttgat ttcctatact gacaggcagt atacagttat agaggacaga agcagaaaaa   1860

agttatgtta acagtggaac aggcccaaga tcaacattat gcgcttgtat tatggggtcc   1920

tggagcagcc tggtaccctc aacttcaaag gaaaaaaggt tatatttggg aatttaaata   1980

tctttttgtt cagcgcaatt acacactaga aaacctagaa ttgcatacaa cgccttggtc   2040

atcctgtgag tgcttgtttg atgatgatat aagggcaatt acatttaaag caaaatttca   2100

aaaaagtgca ccctcctttg tgaagatatc agacttagca acccacctag aggataagtg   2160

ttcaggagtg gttctaatta aagcccagat ttcagagctg gcatttcctc ttacagcagc   2220

tcagaagata tctctaaatg ctcacagttc tctgaagagt attttttctt ctcttcccaa   2280

catcatatat actggctgtg caaaatgtgg attggaacta gaaacagatg agaacaggat   2340

ctacaaacaa tgttttagct gcttgccatt tactatgaag aaaatatatt ataggccagc   2400

gttaatgact gccgttgatg gaagacataa tgtttacatc catgtagaat caaagctgat   2460

agagaagatt cttctcaaca tttctgcaga ctgcctcaac agagtgatag ttccttcctc   2520

agagatcacc tatgggatgg ttgtggcaga cctgttccac tccttgttgg cagtcagcgc   2580

agaaccttgt gtattgaaga ttcagagcct ttttgtgtta gatgaaaaca gctatccatt   2640

acaacaagat ttctccctcc tggattttta tcctgacatg gtaaagcatg gagccaatgc   2700

ccgtctctga ggccagagga agaaattgca ggcatttcaa ggaagaagta ctgaaatgat   2760

ttgtcttttg aaataaatga atgacagggc ttttgctttg gattttttat gaaatatatt   2820

ttacaaagag aattgcacta gatatataaa ttaaaacttt tttctaagaa aatcctgtga   2880

ggtttaaaaa gattgttttt gtcttttggt ttcttccttt cttctggaga aatgatctac   2940

cagtcaaggc aatatgtagc agatccctgg gaattaaagg tttgcccatt tgttcactgt   3000

atttagtccc tgctacattc caggcatcgt actaagtatg gggaaccaca gagaagacac   3060

tccttcagaa actgctgcag tgctttcgct tatccctacc taaaaaaccg tcaatgtgaa   3120

atcatttcct tgattataac tataatgata atggattagt ttatataaac ctatgtttag   3180

acaagttcaa gacaagcgtg tctttctata aaaagtattg aaagtgaagg aaatgagatc   3240

atgtttcaat ttattaaagc agggaagagc gttctgtggt tagttcgtgt ctaggatttg   3300

agtgccttac tgaatgtatt taccagcaaa catgtagcaa tctgttctct cattgtgatt   3360

gtggaagaag ctcatgtaaa atgatagtca ttaatgagga agtatggcgt ggtacttatt   3420

ctgtaagttc agagtatgct gagtgttaat agattgtcat attgcctgaa aataaattca   3480

tgatgacatg aacaagc                                                  3497


<210>  766
<211>  1074
<212>  DNA
<213>  Homo sapiens

<400>  766
gcggccgccg ccgatcacag cagcaggagc cgccgccgcc gcggttgatg tggttgggcc     60

ggggctgagg aggccgccaa gatgccgcag tcaaagtccc ggaagatcgc gatcctgggc    120

taccggtctg tggggaaatc ctcattgacg attcaatttg ttgaaggcca atttgtggac    180

tcctacgatc caaccataga aaacactttt acaaagttga tcacagtaaa tggacaagaa    240

tatcatcttt aacttgtaga cacagccggg caagatgaat attctatctt tcctcagaca    300

tactccatag atattaatgg ctatattctt gtgtattctg ttacatcaat caaaagtttt    360

gaagtgatta aagttatcca tggcaaattg ttggatatgg tggggaaagt acaaatacct    420

attatgttgg ttggaaataa gaaagacctg catatggaaa gggtgatcag ttatgaagaa    480

gggaaagctt tggcagaatc ttggaatgca gcttttttgg aatcttctgc taaagaaaat    540

cagactgctg ttgatgtttt tcgaaggatg attttggagg cagaaaaaat ggacgggggc    600

agcttcacaa ggcaagtctt catgctcggt gatgtgattc tgctgcaaag cccgaggaca    660

ctgggaatat attctagctg aagaagcaaa ctgcccgttc tccttgaaga taaactatgc    720

ttcttttttc ttctgttaac ctgaaagata tcatttgggt cagagctccc ctcccttcag    780

attatgttaa ctctgagtct gtccaaatga gttcacttcc attttcaaat tttaagcaat    840

catattttca atttatatat tgtgtttctt aatattatga ccaagaattt tatcggcatt    900

aatttttcag tgtagtttgt tgtttaaaat aatgtaatca tcaaaatgat gcatattgtt    960

acactactat taactaggct tcaatatatc agtgtttatt tcattgtgtt aaatgtatac   1020

ttgtaaataa aatagctgca aacctcaaaa aaacaaaaaa aaacaaaaaa aaga         1074


<210>  767
<211>  1632
<212>  DNA
<213>  Homo sapiens

<400>  767
atgagcaggg ggtcactgcc ccagaaccat gagggcaccc acatggtcta ccctggctcc     60

tcactcatca gaggaaatga cgagattcca aggtcccctc cggtattgca agctggcctg    120

agccataggg tcctgtccca gcatggcatc aaatgcctgg agctcatcct gcaggagcag    180

ccatggcgga gcccccaggg ttgggtcaaa gtcttgtgtc cagaagcccc ctggtcggca    240

gtcctcttgg cttcccctat cacccagtgt ccagcctgca tgggcccttc agtcccaggg    300

gccatgacca aggcccagtc cccttcacct gtctccatca taagcgtcac cagcctgtct    360

gacaaactgc ccagcaaagt tattgacatt ggcctggccg cctggggatg caaggccctg    420

aacattgtag agaatgagat gccaggcctg atgcacatgt gggagctgta ctcggcctcc    480

aagccactag agggcaacca cagtgccagc tgcctgcaca tgaccatgga gatggccatc    540

cacattgggt ccctcatcac cctgggtgcc ccagcagcaa catcttcctc accctggacc    600

atgtgttggc tgccattgcc aaggctggca ttccagttta cacctggaag ggcaaaagaa    660

cgcagagtac ccatggtgca tcgagcagtc actgtaattc agggatgggc tctcaacatt    720

attctggagg atgggggtga ccttgccaac ctcttccaca ccaagtactc acagctcttg    780

ctgggcatct gaggcacctc caaggagacc atgacgggtc cacaacccac acaggatgat    840

ggtcaatggg atcctgaagg tgcctgccat caatgtcaat gactccctca ccaagagtga    900

gttcaacaag ctctatggct gctgggagtc cctcatagat ggcatcaagt gggccacagt    960

ggtgatgatt gccggcaagg tagcgatggt agcaggctat ggcaatgtgg gcaagggctg   1020

tgcccaggcc ctgtggggtt tcggggccca cgtcatcatc accaagatcg accccatcaa   1080

tgcactgcag gctgccatgg agggctatga ggtgaccacc atggatgaag cctgtcagga   1140

gggcaacatc tttatcacca ccacagcctg tgtcaacatc atccttggcc ggcactttga   1200

acagatgaag gatgatgcca ttgtatgtaa cactggacac tttgaggtgg agatcaatgt   1260

caagtggctc agtgagaacc cttggagaag gtggccatca agccccaggt ggccgggtac   1320

tggatgaaga atgggcgcca caccatcctg ctggctgagg gtcggctggt cagcctgggt   1380

tgtgccatgg gccaccctgg ctttgtgatg agtgactcat caaccaggtg actgcacaga   1440

atgagctgtg aatccaccca gagaagtacc ccattgaggt tcatgtccta cccaagaagc   1500

tggatgaggc agtggctgaa gcccacctgg gcaagctgat catgaaattg accaagctga   1560

ctgagaaaca ggcccagtac ctggggcatc tcccctgatt gccccttcaa ggctgatcac   1620

taccgctact ga                                                       1632


<210>  768
<211>  9601
<212>  DNA
<213>  Homo sapiens

<400>  768
agacactgct gctccggggg gctgacctgg cggggagtgg ccgcgcagtc tgctccggcg     60

ccgctttgtg cgcgcagccg ctggcccctc tactcccggg tctgcccccc gggacacccc    120

tctgcctcgc ccaagtcatg cagccctacc tgcctctcca ctgtggacct ttgggaaccg    180

actcctcacc tcgggggctc gggccttgac tgtgctggga gccggtaggc gtcctccgcg    240

acccgcccgc gcccctcgcg cccgccgggg ccccgggctc caaagttgtg gggaccggcg    300

cgagttggaa agtttgcccg agggctggtg caggcttgga gctgggggcc gtgcgctgcc    360

ctgggaatgt gacccggcca gcgaccaaaa ccttgtgtga ctgagctgaa gagcagtgca    420

tccagattct cctcagaagt gagactttcc aaaggaccaa tgactctgtt tcctgcgccc    480

tttcattttt tcctactctg tagctatgtc tcgatcccgc catgcaaggc cttccagatt    540

agtcaggaag gaagatgtaa acaaaaaaaa gaaaaacagc caactacgaa agacaaccaa    600

gggagccaac aaaaatgtgg catcagtcaa gactttaagc cctggaaaat taaagcaatt    660

aattcaagaa agagatgtta agaaaaaaac agaacctaaa ccacccgtgc cagtcagaag    720

ccttctgaca agagctggag cagcacgcat gaatttggat aggactgagg ttctttttca    780

gaacccagag tccttaacct gcaatgggtt tacaatggcg ctacgaagca cctctcttag    840

caggcgactc tcccaacccc cactggtcgt agccaaatcc aaaaaggttc cactttctaa    900

gggtttagaa aagcaacatg attgtgatta taagatactc cctgctttgg gagtaaagca    960

ctcagaaaat gattcggttc caatgcaaga cacccaagtc cttcctgata tagagactct   1020

aattggtgta caaaatccct ctttacttaa aggtaagagc caagagacaa ctcagttttg   1080

gtcccaaaga gttgaggatt ccaagatcaa tatccctacc cacagtggcc ctgcagctga   1140

gatccttcct gggccactgg aagggacacg ctgtggtgaa ggactattct ctgaagagac   1200

attgaatgat accagtggtt ccccaaaaat gtttgctcag gacacagtgt gtgctccttt   1260

tccccaaaga gcaaccccca aagttacctc tcaaggaaac cccagcattc agttagaaga   1320

gttgggttca cgagtagaat ctcttaagtt atctgattct tacctggatc ccattaaaag   1380

tgaacatgat tgctacccca cctccagtct taataaggtt atacctgact tgaaccttag   1440

aaactgcttg gctcttggtg ggtctacgtc tcctacctct gtaataaaat tcctcttggc   1500

aggctcaaaa caagcgaccc ttggtgctaa accagatcat caagaggcct tcgaagctac   1560

tgcaaatcaa caggaagttt ctgataccac ctctttccta ggacaggcct ttggtgctat   1620

cccacatcaa tgggaacttc ctggtgctga cccagttcat ggtgaggccc tgggtgagac   1680

cccagatcta ccagagattc ctggtgctat tccagtccaa ggagaggtct ttggtactat   1740

tttagaccaa caagaaactc ttggtatgag tgggagtgtt gtcccagact tgcctgtctt   1800

ccttcctgtt cctccaaatc caattgctac ctttaatgct ccttccaaat ggcctgagcc   1860

ccaaagcact gtctcatatg gacttgcagt ccagggtgct atacagattt tgcctttggg   1920

ctcaggacac actcctcaat catcatcaaa ctcagagaaa aattcattac ctccagtaat   1980

ggctataagc aatgtagaaa atgagaagca ggttcatata agcttcctgc cagctaacac   2040

tcaggggttc ccattagccc ctgagagagg actcttccat gcttcactgg gtatagccca   2100

actctctcag gctggtccta gcaaatcaga cagagggagc tcccaggtca gtgtaaccag   2160

cacagttcat gttgtcaaca ccacagtggt gactatgcca gtgccaatgg tcagtacctc   2220

ctcttcttcc tataccactt tgctaccgac tttggaaaag aagaaaagaa agcgatgtgg   2280

ggtctgtgaa ccctgccagc agaagaccaa ctgtggtgaa tgcacttact gcaagaacag   2340

aaagaacagc catcagatct gtaagaaaag aaaatgtgag gagctgaaaa agaaaccatc   2400

tgttgttgtg cctctggagg ttataaagga aaacaagagg ccccagaggg aaaagaagcc   2460

caaagtttta aaggcagatt ttgacaacaa accagtaaat ggccccaagt cagaatccat   2520

ggactacagt agatgtggtc atggggaaga acaaaaattg gaattgaacc cacatactgt   2580

tgaaaatgta actaaaaatg aagacagcat gacaggcatc gaggtggaga agtggacaca   2640

aaacaagaaa tcacagttaa ctgatcacgt gaaaggagat tttagtgcta atgtcccaga   2700

agctgaaaaa tcgaaaaact ctgaagttga caagaaacga accaaatctc caaaattgtt   2760

tgtacaaacc gtaagaaatg gcattaaaca tgtacactgt ttaccagctg aaacaaatgt   2820

ttcatttaaa aaattcaata ttgaagaatt cggcaagaca ttggaaaaca attcttataa   2880

attcctaaaa gacactgcaa accataaaaa cgctatgagc tctgttgcta ctgatatgag   2940

ttgtgatcat ctcaagggga gaagtaacgt tttagtattc cagcagcctg gctttaactg   3000

cagttccatt ccacattctt cacactccat cataaatcat catgctagta tacacaatga   3060

aggtgatcaa ccaaaaactc ctgagaatat accaagtaaa gaaccaaaag atggatctcc   3120

cgttcaacca agtctcttat cgttaatgaa agataggaga ttaacattgg agcaagtggt   3180

agccatagag gccctgactc aactctcaga agccccatca gagaattcct ccccatcaaa   3240

gtcagagaag gatgaggaat cagagcagag aacagccagt ttgcttaata gctgcaaagc   3300

tatcctctac actgtaagaa aagacctcca agacccaaac ttacagggag agccaccaaa   3360

acttaatcac tgtccatctt tggaaaaaca aagttcatgc aacacggtgg ttttcaatgg   3420

gcaaactact accctttcca actcacatat caactcagct actaaccaag catccacaaa   3480

gtcacatgaa tattcaaaag tcacaaattc attatctctt tttataccaa aatcaaattc   3540

atccaagatt gacaccaata aaagtattgc tcaagggata attactcttg acaattgttc   3600

caatgatttg catcagttgc caccaagaaa taatgaagtg gagtattgca accagttact   3660

ggacagcagc aaaaaattgg actcagatga tctatcatgt caggatgcaa cccataccca   3720

aattgaggaa gatgttgcaa cacagttgac acaacttgct tcgataatta agatcaatta   3780

tataaaacca gaggacaaaa aagttgaaag tacaccaaca agccttgtca catgtaatgt   3840

acagcaaaaa tacaatcagg agaagggcac aatacaacag aaaccacctt caagtgtaca   3900

caataatcat ggttcatcat taacaaaaca aaagaaccca acccagaaaa agacaaaatc   3960

caccccatca agagatcggc ggaaaaagaa gcccacagtt gtaagttatc aagaaaatga   4020

tcggcagaag tgggaaaagt tgtcctatat gtatggcaca atatgcgaca tttggatagc   4080

atcgaaattt caaaattttg ggcaattttg tccacatgat tttcctactg tatttgggaa   4140

aatttcttcc tcgaccaaaa tatggaaacc actggctcaa acgaggtcca ttatgcaacc   4200

caaaacagta tttccaccac tcactcagat aaaattacag agatatcctg aatcagcaga   4260

ggaaaaggtg aaggttgaac cattggattc actcagctta tttcatctta aaacggaatc   4320

caacgggaag gcattcactg ataaagctta taattctcag gtacagttaa cggtgaatgc   4380

caatcagaaa gcccatcctt tgacccagcc ctcctctcca cctaaccagt gtgctaacgt   4440

gatggcaggc gatgaccaaa tacggtttca gcaggttgtt aaggagcaac tcatgcatca   4500

gagactgcca acattgcctg gtatctctca tgaaacaccc ttaccggagt cagcactaac   4560

tctcaggaat gtaaatgtag tgtgttcagg tggaattaca gtggtttcta ccaaaagtga   4620

agaggaagtc tgttcatcca gttttggaac atcagaattt tccacagtgg acagtgcaca   4680

gaaaaatttt aatgattatg ccatgaactt ctttactaac cctacaaaaa acctagtgtc   4740

tataactaaa gattctgaac tgcccacctg cagctgtctt gatcgagtta tacaaaaaga   4800

caaaggccca tattatacac accttggggc aggaccaagt gttgctgctg tcagggaaat   4860

catggagaat aggtatggtc aaaaaggaaa cgcaataagg atagaaatag tagtgtacac   4920

cggtaaagaa gggaaaagct ctcatgggtg tccaattgct aagtgggttt taagaagaag   4980

cagtgatgaa gaaaaagttc tttgtttggt ccggcagcgt acaggccacc actgtccaac   5040

tgctgtgatg gtggtgctca tcatggtgtg ggatggcatc cctcttccaa tggccgaccg   5100

gctatacaca gagctcacag agaatctaaa gtcatacaat gggcacccta ccgacagaag   5160

atgcaccctc aatgaaaatc gtacctgtac atgtcaagga attgatccag agacttgtgg   5220

agcttcattc tcttttggct gttcatggag tatgtacttt aatggctgta agtttggtag   5280

aagcccaagc cccagaagat ttagaattga tccaagctct cccttacatg aaaaaaacct   5340

tgaagataac ttacagagtt tggctacacg attagctcca atttataagc agtatgctcc   5400

agtagcttac caaaatcagg tggaatatga aaatgttgcc cgagaatgtc ggcttggcag   5460

caaggaaggt cgtcccttct ctggggtcac tgcttgcctg gacttctgtg ctcatcccca   5520

cagggacatt cacaacatga ataatggaag cactgtggtt tgtaccttaa ctcgagaaga   5580

taaccgctct ttgggtgtta ttcctcaaga tgagcagctc catgtgctac ctctttataa   5640

gctttcagac acagatgagt ttggctccaa ggaaggaatg gaagccaaga tcaaatctgg   5700

ggccatcgag gtcctggcac cccgccgcaa aaaaagaacg tgtttcactc agcctgttcc   5760

ccgttctgga aagaagaggg ctgcgatgat gacagaggtt cttgcacata agataagggc   5820

agtggaaaag aaacctattc cccgaatcaa gcggaagaat aactcaacaa caacaaacaa   5880

cagtaagcct tcgtcactgc caaccttagg gagtaacact gagaccgtgc aacctgaagt   5940

aaaaagtgaa accgaacccc attttatctt aaaaagttca gacaacacta aaacttattc   6000

gctgatgcca tccgctcctc acccagtgaa agaggcatct ccaggcttct cctggtcccc   6060

gaagactgct tcagccacac cagctccact gaagaatgac gcaacagcct catgcgggtt   6120

ttcagaaaga agcagcactc cccactgtac gatgccttcg ggaagactca gtggtgccaa   6180

tgcagctgct gctgatggcc ctggcatttc acagcttggc gaagtggctc ctctccccac   6240

cctgtctgct cctgtgatgg agcccctcat taattctgag ccttccactg gtgtgactga   6300

gccgctaacg cctcatcagc caaaccacca gccctccttc ctcacctctc ctcaagacct   6360

tgcctcttct ccaatggaag aagatgagca gcattctgaa gcagatgagc ctccatcaga   6420

cgaaccccta tctgatgacc ccctgtcacc tgctgaggag aaattgcccc acattgatga   6480

gtattggtca gacagtgagc acatcttttt ggatgcaaat attggtgggg tggccatcgc   6540

acctgctcac ggctcggttt tgattgagtg tgcccggcga gagctgcacg ctaccactcc   6600

tgttgagcac cccaaccgta atcatccaac ccgcctctcc cttgtctttt accagcacaa   6660

aaacctaaat aagccccaac atggttttga actaaacaag attaagtttg aggctaaaga   6720

agctaagaat aagaaaatga aggcctcaga gcaaaaagac caggcagcta atgaaggtcc   6780

agaacagtcc tctgaagtaa atgaattgaa ccaaattcct tctcataaag cattaacatt   6840

aacccatgac aatgttgtca ccgtgtcccc ttatgctctc acacacgttg cggggcccta   6900

taaccattgg gtctgaaggc ttttctcccc ctcttaatgc ctttgctagt gcagtgtatt   6960

ttttcaaggt gctgttaaaa gaaagtcatg ttgtcgttta ctatcttcat ctcacccatt   7020

tcaagtctga ggtaaaaaaa taataatgat aacaaaacgg ggtgggtatt cttaactgtg   7080

actatatttt gacaattggt agaaggtgca cattttaagc aaaaataaaa gttttatagt   7140

tttaaataca taaagaaatg tttcagttag gcattaacct tgatagaatc actcagtttg   7200

gtgctttaaa ttaagtctgt ttactatgaa acaagagtca tttttagagg attttaacag   7260

gttcatgttc tatgatgtaa aatcaagaca cacagtgtta actctacaca gcttctggtg   7320

cttaaccaca tccacacagt taaaaataag ctgaattatt atttcatggt gccattgttc   7380

caacatcttc caatcattgc tagaaaattg gcatattcct ttgaaataaa cttatgaaat   7440

gttttctctc ttaaaatatt tctcctgtgt aaaataaatc attgttgtta gtaatggttg   7500

gaggctgttc ataaattgta aatatatatt ttaaaagcac tttctatttt taaaagtaac   7560

ttgaaataat atagtataag aatcctattg tctattgttt gtgcatattt gcatacaaga   7620

gaaatcattt atccttgctg tgtagagttc catcttgtta actgcagtat gtattctaat   7680

catgtatatg gtttgtgttc ttttactgtg tcctctcaca ttcaagtatt agcaacttgc   7740

agtatataaa atagttagat aatgagaagt tgttaattat ctctaaaatt ggaattagga   7800

agcatatcac caatactgat taacattctc tttggaacta ggtaagagtg gtctcttctt   7860

attgaacaac ctcaatttag tttcatccca cctttctcag tataatccat gagaggtgtt   7920

tccaaaagga gatgagggaa caggataggt ttcagaagag tcaaatgctt ctaatgtctc   7980

aaggtgataa aatacaaaaa ctaagtagac agatatttgt actgaagtct gatacagaat   8040

tagaaaaaaa aaattcttgt tgaaatattt tgaaaacaaa ttccctacta tcatcacatg   8100

cctccccaac cccaagtcaa aaacaagagg aatggtacta caaacatggc tttgtccatt   8160

aagagctaat tcatttgttt atcttagcat actagatttg ggaaaatgat aactcatctt   8220

ttctgataat tgcctatgtt ctaggtaaca ggaaaacagg cattaagttt attttagtct   8280

tcccattttc ttcctattac tttattgact cattttattg caaaacaaaa aggattaccc   8340

aaacaacatg tttcgaacaa ggagaatttt caatgaaata cttgattctg ttaaaatgca   8400

gaggtgctat aacattcaaa gtgtcagatt ccttgggagt atggaaaacc taatggtgct   8460

tctcccttgg aaatgccata ggaagcccac aaccgctaac acttacaatt ttggtgcaaa   8520

agcaaacagt tccagcaggc tctctaaaga aaaactcatt gtaacttatt aaaataatat   8580

ctggtgcaaa gtatctgttt tgagcttttg actaatccaa gtaaaggaat atgaagggat   8640

tgtaaaaaac aaaatgtcca ttgatagacc atcgtgtaca agtagatttc tgcttgttga   8700

atatgtaaaa tagggtaatt cattgacttg ttttagtatt ttgtgtgcct tagatttccg   8760

ttttaagaca tgtatatttt tgtgagccta aggtttctta tatacatata agtatataaa   8820

taagtgattg tttattgctt cagctgcttc aacaagatat ttactagtat tagactatca   8880

ggaatacacc cttgcgagat tatgttttag attttaggcc ttagctccca ctagaaatta   8940

tttcttcacc agatttaatg gataaagttt tatggctctt tatgcatcca ctcatctact   9000

cattcttcga gtctacactt attgaatgcc tgcaaaatct aagtatcact tttatttttc   9060

tttggatcac cacctatgac atagtaaact tgaagaataa aaactaccct cagaaatatt   9120

tttaaaagaa gtagcaaatt atcttcagta taatccatgg taatgtatgc agtaattcaa   9180

attgatctct ctctcaatag gtttcttaac aatctaaact tgaaacatca atgttaattt   9240

ttggaactat tgggatttgt gacgcttgtt gcagtttacc aaaacaagta tttgaaaata   9300

tatagtatca actgaaatgt ttccattccg ttgttgtagt taacatcatg aatggacttc   9360

ttaagctgat taccccactg tgggaaccaa attggattcc tactttgttg gactctcttt   9420

cctgatttta acaatttacc atcccattct ctgccctgtg atttttttta aaagcttatt   9480

caatgttctg cagcattgtg attgtatgct ggctacactg cttttagaat gctctttctc   9540

atgaagcaag gaaataaatt tgtttgaaat gacattttct ctcaaaaaaa aaaaaaaaaa   9600

a                                                                   9601


<210>  769
<211>  2136
<212>  PRT
<213>  Homo sapiens

<400>  769

Met Ser Arg Ser Arg His Ala Arg Pro Ser Arg Leu Val Arg Lys Glu 
1               5                   10                  15


Asp Val Asn Lys Lys Lys Lys Asn Ser Gln Leu Arg Lys Thr Thr Lys 
            20                  25                  30


Gly Ala Asn Lys Asn Val Ala Ser Val Lys Thr Leu Ser Pro Gly Lys 
        35                  40                  45


Leu Lys Gln Leu Ile Gln Glu Arg Asp Val Lys Lys Lys Thr Glu Pro 
    50                  55                  60


Lys Pro Pro Val Pro Val Arg Ser Leu Leu Thr Arg Ala Gly Ala Ala 
65                  70                  75                  80


Arg Met Asn Leu Asp Arg Thr Glu Val Leu Phe Gln Asn Pro Glu Ser 
                85                  90                  95


Leu Thr Cys Asn Gly Phe Thr Met Ala Leu Arg Ser Thr Ser Leu Ser 
            100                 105                 110


Arg Arg Leu Ser Gln Pro Pro Leu Val Val Ala Lys Ser Lys Lys Val 
        115                 120                 125


Pro Leu Ser Lys Gly Leu Glu Lys Gln His Asp Cys Asp Tyr Lys Ile 
    130                 135                 140


Leu Pro Ala Leu Gly Val Lys His Ser Glu Asn Asp Ser Val Pro Met 
145                 150                 155                 160


Gln Asp Thr Gln Val Leu Pro Asp Ile Glu Thr Leu Ile Gly Val Gln 
                165                 170                 175


Asn Pro Ser Leu Leu Lys Gly Lys Ser Gln Glu Thr Thr Gln Phe Trp 
            180                 185                 190


Ser Gln Arg Val Glu Asp Ser Lys Ile Asn Ile Pro Thr His Ser Gly 
        195                 200                 205


Pro Ala Ala Glu Ile Leu Pro Gly Pro Leu Glu Gly Thr Arg Cys Gly 
    210                 215                 220


Glu Gly Leu Phe Ser Glu Glu Thr Leu Asn Asp Thr Ser Gly Ser Pro 
225                 230                 235                 240


Lys Met Phe Ala Gln Asp Thr Val Cys Ala Pro Phe Pro Gln Arg Ala 
                245                 250                 255


Thr Pro Lys Val Thr Ser Gln Gly Asn Pro Ser Ile Gln Leu Glu Glu 
            260                 265                 270


Leu Gly Ser Arg Val Glu Ser Leu Lys Leu Ser Asp Ser Tyr Leu Asp 
        275                 280                 285


Pro Ile Lys Ser Glu His Asp Cys Tyr Pro Thr Ser Ser Leu Asn Lys 
    290                 295                 300


Val Ile Pro Asp Leu Asn Leu Arg Asn Cys Leu Ala Leu Gly Gly Ser 
305                 310                 315                 320


Thr Ser Pro Thr Ser Val Ile Lys Phe Leu Leu Ala Gly Ser Lys Gln 
                325                 330                 335


Ala Thr Leu Gly Ala Lys Pro Asp His Gln Glu Ala Phe Glu Ala Thr 
            340                 345                 350


Ala Asn Gln Gln Glu Val Ser Asp Thr Thr Ser Phe Leu Gly Gln Ala 
        355                 360                 365


Phe Gly Ala Ile Pro His Gln Trp Glu Leu Pro Gly Ala Asp Pro Val 
    370                 375                 380


His Gly Glu Ala Leu Gly Glu Thr Pro Asp Leu Pro Glu Ile Pro Gly 
385                 390                 395                 400


Ala Ile Pro Val Gln Gly Glu Val Phe Gly Thr Ile Leu Asp Gln Gln 
                405                 410                 415


Glu Thr Leu Gly Met Ser Gly Ser Val Val Pro Asp Leu Pro Val Phe 
            420                 425                 430


Leu Pro Val Pro Pro Asn Pro Ile Ala Thr Phe Asn Ala Pro Ser Lys 
        435                 440                 445


Trp Pro Glu Pro Gln Ser Thr Val Ser Tyr Gly Leu Ala Val Gln Gly 
    450                 455                 460


Ala Ile Gln Ile Leu Pro Leu Gly Ser Gly His Thr Pro Gln Ser Ser 
465                 470                 475                 480


Ser Asn Ser Glu Lys Asn Ser Leu Pro Pro Val Met Ala Ile Ser Asn 
                485                 490                 495


Val Glu Asn Glu Lys Gln Val His Ile Ser Phe Leu Pro Ala Asn Thr 
            500                 505                 510


Gln Gly Phe Pro Leu Ala Pro Glu Arg Gly Leu Phe His Ala Ser Leu 
        515                 520                 525


Gly Ile Ala Gln Leu Ser Gln Ala Gly Pro Ser Lys Ser Asp Arg Gly 
    530                 535                 540


Ser Ser Gln Val Ser Val Thr Ser Thr Val His Val Val Asn Thr Thr 
545                 550                 555                 560


Val Val Thr Met Pro Val Pro Met Val Ser Thr Ser Ser Ser Ser Tyr 
                565                 570                 575


Thr Thr Leu Leu Pro Thr Leu Glu Lys Lys Lys Arg Lys Arg Cys Gly 
            580                 585                 590


Val Cys Glu Pro Cys Gln Gln Lys Thr Asn Cys Gly Glu Cys Thr Tyr 
        595                 600                 605


Cys Lys Asn Arg Lys Asn Ser His Gln Ile Cys Lys Lys Arg Lys Cys 
    610                 615                 620


Glu Glu Leu Lys Lys Lys Pro Ser Val Val Val Pro Leu Glu Val Ile 
625                 630                 635                 640


Lys Glu Asn Lys Arg Pro Gln Arg Glu Lys Lys Pro Lys Val Leu Lys 
                645                 650                 655


Ala Asp Phe Asp Asn Lys Pro Val Asn Gly Pro Lys Ser Glu Ser Met 
            660                 665                 670


Asp Tyr Ser Arg Cys Gly His Gly Glu Glu Gln Lys Leu Glu Leu Asn 
        675                 680                 685


Pro His Thr Val Glu Asn Val Thr Lys Asn Glu Asp Ser Met Thr Gly 
    690                 695                 700


Ile Glu Val Glu Lys Trp Thr Gln Asn Lys Lys Ser Gln Leu Thr Asp 
705                 710                 715                 720


His Val Lys Gly Asp Phe Ser Ala Asn Val Pro Glu Ala Glu Lys Ser 
                725                 730                 735


Lys Asn Ser Glu Val Asp Lys Lys Arg Thr Lys Ser Pro Lys Leu Phe 
            740                 745                 750


Val Gln Thr Val Arg Asn Gly Ile Lys His Val His Cys Leu Pro Ala 
        755                 760                 765


Glu Thr Asn Val Ser Phe Lys Lys Phe Asn Ile Glu Glu Phe Gly Lys 
    770                 775                 780


Thr Leu Glu Asn Asn Ser Tyr Lys Phe Leu Lys Asp Thr Ala Asn His 
785                 790                 795                 800


Lys Asn Ala Met Ser Ser Val Ala Thr Asp Met Ser Cys Asp His Leu 
                805                 810                 815


Lys Gly Arg Ser Asn Val Leu Val Phe Gln Gln Pro Gly Phe Asn Cys 
            820                 825                 830


Ser Ser Ile Pro His Ser Ser His Ser Ile Ile Asn His His Ala Ser 
        835                 840                 845


Ile His Asn Glu Gly Asp Gln Pro Lys Thr Pro Glu Asn Ile Pro Ser 
    850                 855                 860


Lys Glu Pro Lys Asp Gly Ser Pro Val Gln Pro Ser Leu Leu Ser Leu 
865                 870                 875                 880


Met Lys Asp Arg Arg Leu Thr Leu Glu Gln Val Val Ala Ile Glu Ala 
                885                 890                 895


Leu Thr Gln Leu Ser Glu Ala Pro Ser Glu Asn Ser Ser Pro Ser Lys 
            900                 905                 910


Ser Glu Lys Asp Glu Glu Ser Glu Gln Arg Thr Ala Ser Leu Leu Asn 
        915                 920                 925


Ser Cys Lys Ala Ile Leu Tyr Thr Val Arg Lys Asp Leu Gln Asp Pro 
    930                 935                 940


Asn Leu Gln Gly Glu Pro Pro Lys Leu Asn His Cys Pro Ser Leu Glu 
945                 950                 955                 960


Lys Gln Ser Ser Cys Asn Thr Val Val Phe Asn Gly Gln Thr Thr Thr 
                965                 970                 975


Leu Ser Asn Ser His Ile Asn Ser Ala Thr Asn Gln Ala Ser Thr Lys 
            980                 985                 990


Ser His Glu Tyr Ser Lys Val Thr Asn Ser Leu Ser Leu Phe Ile Pro 
        995                 1000                1005


Lys Ser Asn Ser Ser Lys Ile Asp Thr Asn Lys Ser Ile Ala Gln Gly 
    1010                1015                1020


Ile Ile Thr Leu Asp Asn Cys Ser Asn Asp Leu His Gln Leu Pro Pro 
1025                1030                1035                1040


Arg Asn Asn Glu Val Glu Tyr Cys Asn Gln Leu Leu Asp Ser Ser Lys 
                1045                1050                1055


Lys Leu Asp Ser Asp Asp Leu Ser Cys Gln Asp Ala Thr His Thr Gln 
            1060                1065                1070


Ile Glu Glu Asp Val Ala Thr Gln Leu Thr Gln Leu Ala Ser Ile Ile 
        1075                1080                1085


Lys Ile Asn Tyr Ile Lys Pro Glu Asp Lys Lys Val Glu Ser Thr Pro 
    1090                1095                1100


Thr Ser Leu Val Thr Cys Asn Val Gln Gln Lys Tyr Asn Gln Glu Lys 
1105                1110                1115                1120


Gly Thr Ile Gln Gln Lys Pro Pro Ser Ser Val His Asn Asn His Gly 
                1125                1130                1135


Ser Ser Leu Thr Lys Gln Lys Asn Pro Thr Gln Lys Lys Thr Lys Ser 
            1140                1145                1150


Thr Pro Ser Arg Asp Arg Arg Lys Lys Lys Pro Thr Val Val Ser Tyr 
        1155                1160                1165


Gln Glu Asn Asp Arg Gln Lys Trp Glu Lys Leu Ser Tyr Met Tyr Gly 
    1170                1175                1180


Thr Ile Cys Asp Ile Trp Ile Ala Ser Lys Phe Gln Asn Phe Gly Gln 
1185                1190                1195                1200


Phe Cys Pro His Asp Phe Pro Thr Val Phe Gly Lys Ile Ser Ser Ser 
                1205                1210                1215


Thr Lys Ile Trp Lys Pro Leu Ala Gln Thr Arg Ser Ile Met Gln Pro 
            1220                1225                1230


Lys Thr Val Phe Pro Pro Leu Thr Gln Ile Lys Leu Gln Arg Tyr Pro 
        1235                1240                1245


Glu Ser Ala Glu Glu Lys Val Lys Val Glu Pro Leu Asp Ser Leu Ser 
    1250                1255                1260


Leu Phe His Leu Lys Thr Glu Ser Asn Gly Lys Ala Phe Thr Asp Lys 
1265                1270                1275                1280


Ala Tyr Asn Ser Gln Val Gln Leu Thr Val Asn Ala Asn Gln Lys Ala 
                1285                1290                1295


His Pro Leu Thr Gln Pro Ser Ser Pro Pro Asn Gln Cys Ala Asn Val 
            1300                1305                1310


Met Ala Gly Asp Asp Gln Ile Arg Phe Gln Gln Val Val Lys Glu Gln 
        1315                1320                1325


Leu Met His Gln Arg Leu Pro Thr Leu Pro Gly Ile Ser His Glu Thr 
    1330                1335                1340


Pro Leu Pro Glu Ser Ala Leu Thr Leu Arg Asn Val Asn Val Val Cys 
1345                1350                1355                1360


Ser Gly Gly Ile Thr Val Val Ser Thr Lys Ser Glu Glu Glu Val Cys 
                1365                1370                1375


Ser Ser Ser Phe Gly Thr Ser Glu Phe Ser Thr Val Asp Ser Ala Gln 
            1380                1385                1390


Lys Asn Phe Asn Asp Tyr Ala Met Asn Phe Phe Thr Asn Pro Thr Lys 
        1395                1400                1405


Asn Leu Val Ser Ile Thr Lys Asp Ser Glu Leu Pro Thr Cys Ser Cys 
    1410                1415                1420


Leu Asp Arg Val Ile Gln Lys Asp Lys Gly Pro Tyr Tyr Thr His Leu 
1425                1430                1435                1440


Gly Ala Gly Pro Ser Val Ala Ala Val Arg Glu Ile Met Glu Asn Arg 
                1445                1450                1455


Tyr Gly Gln Lys Gly Asn Ala Ile Arg Ile Glu Ile Val Val Tyr Thr 
            1460                1465                1470


Gly Lys Glu Gly Lys Ser Ser His Gly Cys Pro Ile Ala Lys Trp Val 
        1475                1480                1485


Leu Arg Arg Ser Ser Asp Glu Glu Lys Val Leu Cys Leu Val Arg Gln 
    1490                1495                1500


Arg Thr Gly His His Cys Pro Thr Ala Val Met Val Val Leu Ile Met 
1505                1510                1515                1520


Val Trp Asp Gly Ile Pro Leu Pro Met Ala Asp Arg Leu Tyr Thr Glu 
                1525                1530                1535


Leu Thr Glu Asn Leu Lys Ser Tyr Asn Gly His Pro Thr Asp Arg Arg 
            1540                1545                1550


Cys Thr Leu Asn Glu Asn Arg Thr Cys Thr Cys Gln Gly Ile Asp Pro 
        1555                1560                1565


Glu Thr Cys Gly Ala Ser Phe Ser Phe Gly Cys Ser Trp Ser Met Tyr 
    1570                1575                1580


Phe Asn Gly Cys Lys Phe Gly Arg Ser Pro Ser Pro Arg Arg Phe Arg 
1585                1590                1595                1600


Ile Asp Pro Ser Ser Pro Leu His Glu Lys Asn Leu Glu Asp Asn Leu 
                1605                1610                1615


Gln Ser Leu Ala Thr Arg Leu Ala Pro Ile Tyr Lys Gln Tyr Ala Pro 
            1620                1625                1630


Val Ala Tyr Gln Asn Gln Val Glu Tyr Glu Asn Val Ala Arg Glu Cys 
        1635                1640                1645


Arg Leu Gly Ser Lys Glu Gly Arg Pro Phe Ser Gly Val Thr Ala Cys 
    1650                1655                1660


Leu Asp Phe Cys Ala His Pro His Arg Asp Ile His Asn Met Asn Asn 
1665                1670                1675                1680


Gly Ser Thr Val Val Cys Thr Leu Thr Arg Glu Asp Asn Arg Ser Leu 
                1685                1690                1695


Gly Val Ile Pro Gln Asp Glu Gln Leu His Val Leu Pro Leu Tyr Lys 
            1700                1705                1710


Leu Ser Asp Thr Asp Glu Phe Gly Ser Lys Glu Gly Met Glu Ala Lys 
        1715                1720                1725


Ile Lys Ser Gly Ala Ile Glu Val Leu Ala Pro Arg Arg Lys Lys Arg 
    1730                1735                1740


Thr Cys Phe Thr Gln Pro Val Pro Arg Ser Gly Lys Lys Arg Ala Ala 
1745                1750                1755                1760


Met Met Thr Glu Val Leu Ala His Lys Ile Arg Ala Val Glu Lys Lys 
                1765                1770                1775


Pro Ile Pro Arg Ile Lys Arg Lys Asn Asn Ser Thr Thr Thr Asn Asn 
            1780                1785                1790


Ser Lys Pro Ser Ser Leu Pro Thr Leu Gly Ser Asn Thr Glu Thr Val 
        1795                1800                1805


Gln Pro Glu Val Lys Ser Glu Thr Glu Pro His Phe Ile Leu Lys Ser 
    1810                1815                1820


Ser Asp Asn Thr Lys Thr Tyr Ser Leu Met Pro Ser Ala Pro His Pro 
1825                1830                1835                1840


Val Lys Glu Ala Ser Pro Gly Phe Ser Trp Ser Pro Lys Thr Ala Ser 
                1845                1850                1855


Ala Thr Pro Ala Pro Leu Lys Asn Asp Ala Thr Ala Ser Cys Gly Phe 
            1860                1865                1870


Ser Glu Arg Ser Ser Thr Pro His Cys Thr Met Pro Ser Gly Arg Leu 
        1875                1880                1885


Ser Gly Ala Asn Ala Ala Ala Ala Asp Gly Pro Gly Ile Ser Gln Leu 
    1890                1895                1900


Gly Glu Val Ala Pro Leu Pro Thr Leu Ser Ala Pro Val Met Glu Pro 
1905                1910                1915                1920


Leu Ile Asn Ser Glu Pro Ser Thr Gly Val Thr Glu Pro Leu Thr Pro 
                1925                1930                1935


His Gln Pro Asn His Gln Pro Ser Phe Leu Thr Ser Pro Gln Asp Leu 
            1940                1945                1950


Ala Ser Ser Pro Met Glu Glu Asp Glu Gln His Ser Glu Ala Asp Glu 
        1955                1960                1965


Pro Pro Ser Asp Glu Pro Leu Ser Asp Asp Pro Leu Ser Pro Ala Glu 
    1970                1975                1980


Glu Lys Leu Pro His Ile Asp Glu Tyr Trp Ser Asp Ser Glu His Ile 
1985                1990                1995                2000


Phe Leu Asp Ala Asn Ile Gly Gly Val Ala Ile Ala Pro Ala His Gly 
                2005                2010                2015


Ser Val Leu Ile Glu Cys Ala Arg Arg Glu Leu His Ala Thr Thr Pro 
            2020                2025                2030


Val Glu His Pro Asn Arg Asn His Pro Thr Arg Leu Ser Leu Val Phe 
        2035                2040                2045


Tyr Gln His Lys Asn Leu Asn Lys Pro Gln His Gly Phe Glu Leu Asn 
    2050                2055                2060


Lys Ile Lys Phe Glu Ala Lys Glu Ala Lys Asn Lys Lys Met Lys Ala 
2065                2070                2075                2080


Ser Glu Gln Lys Asp Gln Ala Ala Asn Glu Gly Pro Glu Gln Ser Ser 
                2085                2090                2095


Glu Val Asn Glu Leu Asn Gln Ile Pro Ser His Lys Ala Leu Thr Leu 
            2100                2105                2110


Thr His Asp Asn Val Val Thr Val Ser Pro Tyr Ala Leu Thr His Val 
        2115                2120                2125


Ala Gly Pro Tyr Asn His Trp Val 
    2130                2135


<210>  770
<211>  3858
<212>  DNA
<213>  Homo sapiens

<400>  770
gaagttggcg catgcgccta aagctgacgg gtttgaaatg gcttcgatgt tagccgggac     60

ccgactcaga tcgatgctat agaagacaaa caagggaagg ttttttttcc ttttgcatca    120

tggctcaatt tggaggacag aagaatccgc catgggctac tcagtttaca gccactgcag    180

tatcacagcc agctgcactg ggtgttcaac agccatcact ccttggagca tctcctacca    240

tttatacaca gcaaactgca ttggcagcag caggccttac cacacaaact ccagcaaact    300

atcagttaac acaaactgct gcattgcagc aacaagccgc agctgcagca gctgcattac    360

aacagcaata ttcacaacct cagcaggccc tgtatagtgt gcaacaacag ttacagcaac    420

cccagcaaac cctcttaaca cagccagctg ttgcactgcc tacaagcctt agcctgtcta    480

ctcctcagcc aacagcacaa ataactgtat catatccaac accaaggtcc agtcaacagc    540

aaacccagcc tcagaagcag cgtgttttca caggggtggt tacaaaacta catgatacgt    600

ttggatttgt ggatgaagat gtattctttc agcttagtgc tgtcaaaggg aaaacccccc    660

aagtaggtga cagagtattg gttgaagcta cttataatcc taatatgcct tttaaatgga    720

atgcacagag aattcaaaca ctaccaaatc agaatcagtc gcaaacccag ccattactga    780

agactcctcc tgctgtactt cagccaattg caccacagac aacatttggt gttcagactc    840

agccccagcc ccagtcactg ctgcaggcac agatttcagc agcttctatt acaccactat    900

tgcagactca accacagccc ttattacagc agcctcagca aaaagctggt ttattgcagc    960

ctcctgttcg tatagtttca cagccacaac cggcacgacg attagatccc ccatcccgat   1020

tttcaggaag aaatgacaga ggggatcaag tgcctaacag aaaagatgat cgaagtcgtg   1080

agagagagag agaaagacgt agatcgagag aaagatcacc tcagaggaaa cgttcccggg   1140

aaagatctcc acgaagagag cgagagcgat cacctcggag agttcgacgt gttgttccac   1200

gttacacagt tcagttttca aagttttctt tagattgtcc cagttgtgac atgatggaac   1260

taaggcgccg ttatcaaaat ttgtatatac ctagtgactt ttttgatgct caatttacat   1320

gggtggatgc tttccctttg tcaagaccat ttcagctggg aaattactgc aatttttatg   1380

taatgcacag agaagtagag tccttagaaa aaaatatggc cattcttgat ccaccagatg   1440

ctgaccactt atacagtgca aaggtaatgc tgatggctag ccctagtatg gaagatttat   1500

atcataagtc atgtgctctt gctgaggacc cacaagaact tcgagatgga ttccaacatc   1560

ctgctagact tgttaagttt ttagtgggca tgaaaggcaa ggatgaagct atggccattg   1620

gaggccactg gtctccttcg ttggatggac cagacccaga aaaagatccc tctgtgttga   1680

ttaagactgc tattcgttgt tgtaaggctc tgacaggcat tgatctaagt gtgtgcacac   1740

aatggtaccg ttttgcagag attcgctacc atcgccctga ggagacccac aaggggcgta   1800

cagttccagc tcatgtggag acagtggttt tatttttccc ggatgtttgg cattgccttc   1860

ccacccgctc agagtgggaa accctctccc gaggatacaa gcagcagctg gtcgagaagc   1920

ttcagggtga acgcaaggag gctgatggag aacaggatga agaagagaag gatgatggtg   1980

aagctaaaga aatttctaca cctacccatt ggtctaaact tgatccaaag acaatgaagg   2040

taaatgacct ccgaaaagaa ttagaaagtc gagctcttag ttccaaagga ttaaaatccc   2100

agttaatagc ccgattgaca aaacagctta aagtagagga acaaaaagaa gaacagaagg   2160

agttagagaa atctgaaaaa gaagaggatg aggatgatga taggaaatct gaagacgata   2220

aagaggaaga agaaaggaaa cgtcaagagg aaatagaacg ccagcgtcga gaaagaagat   2280

atattttgcc tgatgaaccg gccatcattg tacatccaaa ttgggctgca aaaagtggca   2340

agtttgattg tagcatcatg tctttgagtg tcctattgga ctacagatta gaggataata   2400

aagaacattc atttgaggtt tcattgtttg cggaactttt caacgaaatg cttcaaagag   2460

attttggtgt ccgtatatac aaatcattac tgtctcttcc tgagaaagag gacaaaaaag   2520

aaaaggataa aaaaagcaaa aaagatgaga gaaaagataa aaaagaagaa agagatgatg   2580

aaactgatga accaaaaccc aaacggagaa aatcaggcga tgataaagat aaaaaagaag   2640

atagagatga aaggaagaaa gaagataaaa gaaaagatga ttctaaagat gatgatgaaa   2700

ctgaagaaga taacaatcaa gatgaatatg accctatgga agcagaagaa gctgaggatg   2760

aagaagatga tagggatgag gaagaaatga ccaaacgaga tgacaaaaga gatatcaaca   2820

gatactgcaa ggagaggccc tctaaagata aggaaaaaga aaagactcaa atgatcacaa   2880

ttaacagaga tctgttaatg gcttttgttt attttgatca aagtcattgt ggttaccttc   2940

ttgaaaagga tttggaagaa atactttata ctcttggact acatctttct cgggctcagg   3000

taaagaagct tcttaataaa gtagtgctcc gtgaatcttg cttttaccgg aaattaacag   3060

acacctcaaa agatgaagag aaccatgaag agtctgagtc attgcaggaa gatatgctag   3120

gaaacagatt attacttcca acaccaacag taaagcagga atcaaaggat gtggaagaaa   3180

atgttggcct cattgtgtac aatggtgcaa tggtagatgt aggaagcctc ttgcaaaaat   3240

tggaaaagag cgaaaaagta agagctgagg tagaacagaa gctgcagtta ctagaagaaa   3300

aaacagatga agatgaaaaa accatattaa atttggagaa ttccaacaaa agcctctctg   3360

gtgaactcag agaagttaaa aaggacctta gtcagttaca agaaaactta aagatttcgg   3420

aaaacatgaa tttacaattt gaaaaccaaa tgaataagac aatcagaaac ttatctacgg   3480

taatggatga aatccacact gttctcaaga aggataatgt aaagaatgaa gacaaagatc   3540

aaaaatccaa ggagaatggt gccagtgtat gataaaatcc atgtagtgat gaggaatggt   3600

gttaaataat gtaatatata aaaatcatga tataagaatg tttgaaggtg atgcatgttt   3660

gattttagta gtataaatgt attttagttc aaatgatgta taaagtttta tgaatgtgag   3720

tttctgcttt tgaaaattgc ttgtaattcc tagccttcaa attattaaac actccttgag   3780

tgaaataatt ttgcattgca aagtgtttta ggatgaactt tgttatagtt ttaactccaa   3840

taaagttcat cagtttaa                                                 3858


<210>  771
<211>  1150
<212>  PRT
<213>  Homo sapiens

<400>  771

Met Ala Gln Phe Gly Gly Gln Lys Asn Pro Pro Trp Ala Thr Gln Phe 
1               5                   10                  15


Thr Ala Thr Ala Val Ser Gln Pro Ala Ala Leu Gly Val Gln Gln Pro 
            20                  25                  30


Ser Leu Leu Gly Ala Ser Pro Thr Ile Tyr Thr Gln Gln Thr Ala Leu 
        35                  40                  45


Ala Ala Ala Gly Leu Thr Thr Gln Thr Pro Ala Asn Tyr Gln Leu Thr 
    50                  55                  60


Gln Thr Ala Ala Leu Gln Gln Gln Ala Ala Ala Ala Ala Ala Ala Leu 
65                  70                  75                  80


Gln Gln Gln Tyr Ser Gln Pro Gln Gln Ala Leu Tyr Ser Val Gln Gln 
                85                  90                  95


Gln Leu Gln Gln Pro Gln Gln Thr Leu Leu Thr Gln Pro Ala Val Ala 
            100                 105                 110


Leu Pro Thr Ser Leu Ser Leu Ser Thr Pro Gln Pro Thr Ala Gln Ile 
        115                 120                 125


Thr Val Ser Tyr Pro Thr Pro Arg Ser Ser Gln Gln Gln Thr Gln Pro 
    130                 135                 140


Gln Lys Gln Arg Val Phe Thr Gly Val Val Thr Lys Leu His Asp Thr 
145                 150                 155                 160


Phe Gly Phe Val Asp Glu Asp Val Phe Phe Gln Leu Ser Ala Val Lys 
                165                 170                 175


Gly Lys Thr Pro Gln Val Gly Asp Arg Val Leu Val Glu Ala Thr Tyr 
            180                 185                 190


Asn Pro Asn Met Pro Phe Lys Trp Asn Ala Gln Arg Ile Gln Thr Leu 
        195                 200                 205


Pro Asn Gln Asn Gln Ser Gln Thr Gln Pro Leu Leu Lys Thr Pro Pro 
    210                 215                 220


Ala Val Leu Gln Pro Ile Ala Pro Gln Thr Thr Phe Gly Val Gln Thr 
225                 230                 235                 240


Gln Pro Gln Pro Gln Ser Leu Leu Gln Ala Gln Ile Ser Ala Ala Ser 
                245                 250                 255


Ile Thr Pro Leu Leu Gln Thr Gln Pro Gln Pro Leu Leu Gln Gln Pro 
            260                 265                 270


Gln Gln Lys Ala Gly Leu Leu Gln Pro Pro Val Arg Ile Val Ser Gln 
        275                 280                 285


Pro Gln Pro Ala Arg Arg Leu Asp Pro Pro Ser Arg Phe Ser Gly Arg 
    290                 295                 300


Asn Asp Arg Gly Asp Gln Val Pro Asn Arg Lys Asp Asp Arg Ser Arg 
305                 310                 315                 320


Glu Arg Glu Arg Glu Arg Arg Arg Ser Arg Glu Arg Ser Pro Gln Arg 
                325                 330                 335


Lys Arg Ser Arg Glu Arg Ser Pro Arg Arg Glu Arg Glu Arg Ser Pro 
            340                 345                 350


Arg Arg Val Arg Arg Val Val Pro Arg Tyr Thr Val Gln Phe Ser Lys 
        355                 360                 365


Phe Ser Leu Asp Cys Pro Ser Cys Asp Met Met Glu Leu Arg Arg Arg 
    370                 375                 380


Tyr Gln Asn Leu Tyr Ile Pro Ser Asp Phe Phe Asp Ala Gln Phe Thr 
385                 390                 395                 400


Trp Val Asp Ala Phe Pro Leu Ser Arg Pro Phe Gln Leu Gly Asn Tyr 
                405                 410                 415


Cys Asn Phe Tyr Val Met His Arg Glu Val Glu Ser Leu Glu Lys Asn 
            420                 425                 430


Met Ala Ile Leu Asp Pro Pro Asp Ala Asp His Leu Tyr Ser Ala Lys 
        435                 440                 445


Val Met Leu Met Ala Ser Pro Ser Met Glu Asp Leu Tyr His Lys Ser 
    450                 455                 460


Cys Ala Leu Ala Glu Asp Pro Gln Glu Leu Arg Asp Gly Phe Gln His 
465                 470                 475                 480


Pro Ala Arg Leu Val Lys Phe Leu Val Gly Met Lys Gly Lys Asp Glu 
                485                 490                 495


Ala Met Ala Ile Gly Gly His Trp Ser Pro Ser Leu Asp Gly Pro Asp 
            500                 505                 510


Pro Glu Lys Asp Pro Ser Val Leu Ile Lys Thr Ala Ile Arg Cys Cys 
        515                 520                 525


Lys Ala Leu Thr Gly Ile Asp Leu Ser Val Cys Thr Gln Trp Tyr Arg 
    530                 535                 540


Phe Ala Glu Ile Arg Tyr His Arg Pro Glu Glu Thr His Lys Gly Arg 
545                 550                 555                 560


Thr Val Pro Ala His Val Glu Thr Val Val Leu Phe Phe Pro Asp Val 
                565                 570                 575


Trp His Cys Leu Pro Thr Arg Ser Glu Trp Glu Thr Leu Ser Arg Gly 
            580                 585                 590


Tyr Lys Gln Gln Leu Val Glu Lys Leu Gln Gly Glu Arg Lys Glu Ala 
        595                 600                 605


Asp Gly Glu Gln Asp Glu Glu Glu Lys Asp Asp Gly Glu Ala Lys Glu 
    610                 615                 620


Ile Ser Thr Pro Thr His Trp Ser Lys Leu Asp Pro Lys Thr Met Lys 
625                 630                 635                 640


Val Asn Asp Leu Arg Lys Glu Leu Glu Ser Arg Ala Leu Ser Ser Lys 
                645                 650                 655


Gly Leu Lys Ser Gln Leu Ile Ala Arg Leu Thr Lys Gln Leu Lys Val 
            660                 665                 670


Glu Glu Gln Lys Glu Glu Gln Lys Glu Leu Glu Lys Ser Glu Lys Glu 
        675                 680                 685


Glu Asp Glu Asp Asp Asp Arg Lys Ser Glu Asp Asp Lys Glu Glu Glu 
    690                 695                 700


Glu Arg Lys Arg Gln Glu Glu Ile Glu Arg Gln Arg Arg Glu Arg Arg 
705                 710                 715                 720


Tyr Ile Leu Pro Asp Glu Pro Ala Ile Ile Val His Pro Asn Trp Ala 
                725                 730                 735


Ala Lys Ser Gly Lys Phe Asp Cys Ser Ile Met Ser Leu Ser Val Leu 
            740                 745                 750


Leu Asp Tyr Arg Leu Glu Asp Asn Lys Glu His Ser Phe Glu Val Ser 
        755                 760                 765


Leu Phe Ala Glu Leu Phe Asn Glu Met Leu Gln Arg Asp Phe Gly Val 
    770                 775                 780


Arg Ile Tyr Lys Ser Leu Leu Ser Leu Pro Glu Lys Glu Asp Lys Lys 
785                 790                 795                 800


Glu Lys Asp Lys Lys Ser Lys Lys Asp Glu Arg Lys Asp Lys Lys Glu 
                805                 810                 815


Glu Arg Asp Asp Glu Thr Asp Glu Pro Lys Pro Lys Arg Arg Lys Ser 
            820                 825                 830


Gly Asp Asp Lys Asp Lys Lys Glu Asp Arg Asp Glu Arg Lys Lys Glu 
        835                 840                 845


Asp Lys Arg Lys Asp Asp Ser Lys Asp Asp Asp Glu Thr Glu Glu Asp 
    850                 855                 860


Asn Asn Gln Asp Glu Tyr Asp Pro Met Glu Ala Glu Glu Ala Glu Asp 
865                 870                 875                 880


Glu Glu Asp Asp Arg Asp Glu Glu Glu Met Thr Lys Arg Asp Asp Lys 
                885                 890                 895


Arg Asp Ile Asn Arg Tyr Cys Lys Glu Arg Pro Ser Lys Asp Lys Glu 
            900                 905                 910


Lys Glu Lys Thr Gln Met Ile Thr Ile Asn Arg Asp Leu Leu Met Ala 
        915                 920                 925


Phe Val Tyr Phe Asp Gln Ser His Cys Gly Tyr Leu Leu Glu Lys Asp 
    930                 935                 940


Leu Glu Glu Ile Leu Tyr Thr Leu Gly Leu His Leu Ser Arg Ala Gln 
945                 950                 955                 960


Val Lys Lys Leu Leu Asn Lys Val Val Leu Arg Glu Ser Cys Phe Tyr 
                965                 970                 975


Arg Lys Leu Thr Asp Thr Ser Lys Asp Glu Glu Asn His Glu Glu Ser 
            980                 985                 990


Glu Ser Leu Gln Glu Asp Met Leu Gly Asn Arg Leu Leu Leu Pro Thr 
        995                 1000                1005


Pro Thr Val Lys Gln Glu Ser Lys Asp Val Glu Glu Asn Val Gly Leu 
    1010                1015                1020


Ile Val Tyr Asn Gly Ala Met Val Asp Val Gly Ser Leu Leu Gln Lys 
1025                1030                1035                1040


Leu Glu Lys Ser Glu Lys Val Arg Ala Glu Val Glu Gln Lys Leu Gln 
                1045                1050                1055


Leu Leu Glu Glu Lys Thr Asp Glu Asp Glu Lys Thr Ile Leu Asn Leu 
            1060                1065                1070


Glu Asn Ser Asn Lys Ser Leu Ser Gly Glu Leu Arg Glu Val Lys Lys 
        1075                1080                1085


Asp Leu Ser Gln Leu Gln Glu Asn Leu Lys Ile Ser Glu Asn Met Asn 
    1090                1095                1100


Leu Gln Phe Glu Asn Gln Met Asn Lys Thr Ile Arg Asn Leu Ser Thr 
1105                1110                1115                1120


Val Met Asp Glu Ile His Thr Val Leu Lys Lys Asp Asn Val Lys Asn 
                1125                1130                1135


Glu Asp Lys Asp Gln Lys Ser Lys Glu Asn Gly Ala Ser Val 
            1140                1145                1150


<210>  772
<211>  3293
<212>  DNA
<213>  Homo sapiens

<400>  772
atggcccggc ccgtgcagct ggcgccgggc tcgctggcgc tagtgctgtg ccggctggag     60

gcgcagaagg cggcgggggc cgcggaggag cctggtgggc gcgcggtgtt ccgcgctttc    120

cgtcgcgcca acgcgcgctg cttctggaac gcgcggctgg cgcgcgccgc ctcgcggctg    180

gccttccagg gctggctgcg gcggggggtg ctgctggtgc gcgcgccccc cgcctgcctg    240

caggtgctgc gcgatgcctg gcggcgccgg gccctgcggc cgccgcgcgg cttccgcatc    300

agggcggtgg gtgatgtctt tccagtgcaa atgaatccaa taactcaatc tcagttcgta    360

cctttgggtg aagttctttg ctgtgctata tctgatatga atacagctca gattgtagta    420

acgcaggaat cacttttgga gcgtttgatg aaacattacc caggcattgc aattccatcg    480

gaagatattc tttataccac tctgggaacg ctgattaaag aaaggaagat ttatcacact    540

ggagaaggat acttcatagt tactcctcag acttacttca ttacaaatac aaccacccag    600

gaaaataaga gaatgctgcc atcagatgaa agtcgcctga tgccagcttc catgacatat    660

ctggtgagca tggagagctg tgcagagtca gcccaagaga atgctgcccc catatcccac    720

tgtcagtctt gccagtgttt ccgggacatg cacactcagg atgttcagga agcaccagtt    780

gctgcagaag tgactaggaa gagtcacaga ggtcttgggg aatccgtatc ttgggtacag    840

aatggggcag tttcagtgtc tgcggagcac cacatttgtg agagcaccaa acctttacca    900

tacacaagag ataaagaaaa aggcaagaag tttggtttta gtctcttatg gcgcagctta    960

tctagaaagg agaagcccaa aacagaacac agcagtttct ctgctcagtt cccacctgaa   1020

gaatggcccg tccgagatga agatgacttg gacaatatcc ctcgagatgt tgaacatgag   1080

ataatcaaac gaattaaccc cattttgact gttgacaatt taatcaaaca cactgtccta   1140

atgcaaaaat acgaagaaca gaaaaaatat aatagccagg gcacttccac tgacatgctg   1200

acaatcgggc ataagtatcc ttcaaaagag ggggttaaga aaaggcaggg tctgtctgca   1260

aaacctcaag ggcagggcca ttctcgaagg gatagacaca aagccaggaa tcagggaagt   1320

gagtttcagc caggaagcat tagactggag aaacacccca agctccctgc tacacagccc   1380

atccccagaa ttaaaagccc aaatgaaatg gtaggtcaga aaccacttgg tgagattaca   1440

acagtgctag gttcccattt gatttacaaa aagcgaatca gtaatccttt ccagggtttg   1500

tctcaccgag gaagcacaat atccaaaggg cacaaaattc agaagacgag tgatctgaaa   1560

cccagccaga ctggaccaaa ggaaaagcct ttccaaaagc ctaggtcctt ggattcctca   1620

agaatctttg atggtaaagc caaagagcca tatgctgaac aacctaatga taaaatggaa   1680

gcagaatcca tttacataaa tgaccctact gtcaaaccca tcaatgatga cttcagaggt   1740

cacctcttca gtcaccctca acagagcatg ttgcaaaatg atggtaaatg ctgtcccttt   1800

atggaaagca tgttgagata tgaagtgtat ggtggagaaa atgaggtaat tcctgaagtc   1860

ttgaggaaaa gtcattccca ctttgacaaa ttaggggaga ccaaacagac tccgcatagt   1920

ctgccatcac gaggtgcctc cttttcagac cgaacaccct ctgcttgtag attagtggat   1980

aacacaatac accagtttca aaatcttggc cttttggatt acccagttgg cgtgaaccct   2040

ttaagacaag ctgcaagaca agacaaagac tcagaagaat tattgagaaa aggatttgtc   2100

caggatgcag agactacaag cctagaaaat gaacagcttt ctaacgatga ccaggccttg   2160

tatcagaatg aagtggaaga tgatgatggt gcctgtagtt cattatatct agaggaggat   2220

gacatttctg agaatgacga cttacgtcaa atgctgcctg gccacagtca gtattccttc   2280

acaggtggaa gccagggaaa tcatttagga aaacaaaaag tgattgagag atctctgacc   2340

gagtacaaca gcacaatgga gagggttgag tctcaggtgc ttaaaagaaa tgaatgctac   2400

aaacccactg ggctgcatgc taccccaggt gaaagccaag aacctaacct ctctgctgaa   2460

agttgtggcc taaattcagg ggcccagttt ggttttaact acgaagaaga acccagtgtt   2520

gctaaatgtg tacaggcctc agcacctgct gatgaaagaa tctttgatta ctatagcgca   2580

agaaaagcca gttttgaagc tgaagtcata caagacacta ttggtgacac aggaaagaag   2640

ccagctagct ggagtcagag tcctcagaat caggaaatga gaaaacattt cccacaaaag   2700

ttccaacttt tcaacacttc acatatgcca gtgttggctc aggatgtcca atatgaacac   2760

agtcacttgg aagggacaga aaatcacagc atggcaggag atagtggaat agattctcca   2820

cggacacaga gtctgggatc taataattca gtcattttgg atggactaaa aagaagacag   2880

aattttctgc aaaatgtcga aggcacaaag agcagtcaac cactcacatc taattcctta   2940

ctaccgctaa ctccagtcat aaacgtttaa ttttcttttg gaaacctact tttttcttta   3000

taaaaaggta gagcattatt acagaatctt tcaatcatgt aagaattgag tatataagaa   3060

ttgtctaaag gcaagcatat ctatactatt aaccacatta cacattttgt tctaattact   3120

ggcttttttt cctcttttgg tgtcttaagg ctttttgaag cttattttac tgtgagttta   3180

ttgggagtat atagattatt ttcgattaaa aagtggaatt attggtcccc ttccaattgt   3240

aattatcttg aatttttata cattagtttc tcaaatatat agaatgccaa ttt          3293


<210>  773
<211>  989
<212>  PRT
<213>  Homo sapiens

<400>  773

Met Ala Arg Pro Val Gln Leu Ala Pro Gly Ser Leu Ala Leu Val Leu 
1               5                   10                  15


Cys Arg Leu Glu Ala Gln Lys Ala Ala Gly Ala Ala Glu Glu Pro Gly 
            20                  25                  30


Gly Arg Ala Val Phe Arg Ala Phe Arg Arg Ala Asn Ala Arg Cys Phe 
        35                  40                  45


Trp Asn Ala Arg Leu Ala Arg Ala Ala Ser Arg Leu Ala Phe Gln Gly 
    50                  55                  60


Trp Leu Arg Arg Gly Val Leu Leu Val Arg Ala Pro Pro Ala Cys Leu 
65                  70                  75                  80


Gln Val Leu Arg Asp Ala Trp Arg Arg Arg Ala Leu Arg Pro Pro Arg 
                85                  90                  95


Gly Phe Arg Ile Arg Ala Val Gly Asp Val Phe Pro Val Gln Met Asn 
            100                 105                 110


Pro Ile Thr Gln Ser Gln Phe Val Pro Leu Gly Glu Val Leu Cys Cys 
        115                 120                 125


Ala Ile Ser Asp Met Asn Thr Ala Gln Ile Val Val Thr Gln Glu Ser 
    130                 135                 140


Leu Leu Glu Arg Leu Met Lys His Tyr Pro Gly Ile Ala Ile Pro Ser 
145                 150                 155                 160


Glu Asp Ile Leu Tyr Thr Thr Leu Gly Thr Leu Ile Lys Glu Arg Lys 
                165                 170                 175


Ile Tyr His Thr Gly Glu Gly Tyr Phe Ile Val Thr Pro Gln Thr Tyr 
            180                 185                 190


Phe Ile Thr Asn Thr Thr Thr Gln Glu Asn Lys Arg Met Leu Pro Ser 
        195                 200                 205


Asp Glu Ser Arg Leu Met Pro Ala Ser Met Thr Tyr Leu Val Ser Met 
    210                 215                 220


Glu Ser Cys Ala Glu Ser Ala Gln Glu Asn Ala Ala Pro Ile Ser His 
225                 230                 235                 240


Cys Gln Ser Cys Gln Cys Phe Arg Asp Met His Thr Gln Asp Val Gln 
                245                 250                 255


Glu Ala Pro Val Ala Ala Glu Val Thr Arg Lys Ser His Arg Gly Leu 
            260                 265                 270


Gly Glu Ser Val Ser Trp Val Gln Asn Gly Ala Val Ser Val Ser Ala 
        275                 280                 285


Glu His His Ile Cys Glu Ser Thr Lys Pro Leu Pro Tyr Thr Arg Asp 
    290                 295                 300


Lys Glu Lys Gly Lys Lys Phe Gly Phe Ser Leu Leu Trp Arg Ser Leu 
305                 310                 315                 320


Ser Arg Lys Glu Lys Pro Lys Thr Glu His Ser Ser Phe Ser Ala Gln 
                325                 330                 335


Phe Pro Pro Glu Glu Trp Pro Val Arg Asp Glu Asp Asp Leu Asp Asn 
            340                 345                 350


Ile Pro Arg Asp Val Glu His Glu Ile Ile Lys Arg Ile Asn Pro Ile 
        355                 360                 365


Leu Thr Val Asp Asn Leu Ile Lys His Thr Val Leu Met Gln Lys Tyr 
    370                 375                 380


Glu Glu Gln Lys Lys Tyr Asn Ser Gln Gly Thr Ser Thr Asp Met Leu 
385                 390                 395                 400


Thr Ile Gly His Lys Tyr Pro Ser Lys Glu Gly Val Lys Lys Arg Gln 
                405                 410                 415


Gly Leu Ser Ala Lys Pro Gln Gly Gln Gly His Ser Arg Arg Asp Arg 
            420                 425                 430


His Lys Ala Arg Asn Gln Gly Ser Glu Phe Gln Pro Gly Ser Ile Arg 
        435                 440                 445


Leu Glu Lys His Pro Lys Leu Pro Ala Thr Gln Pro Ile Pro Arg Ile 
    450                 455                 460


Lys Ser Pro Asn Glu Met Val Gly Gln Lys Pro Leu Gly Glu Ile Thr 
465                 470                 475                 480


Thr Val Leu Gly Ser His Leu Ile Tyr Lys Lys Arg Ile Ser Asn Pro 
                485                 490                 495


Phe Gln Gly Leu Ser His Arg Gly Ser Thr Ile Ser Lys Gly His Lys 
            500                 505                 510


Ile Gln Lys Thr Ser Asp Leu Lys Pro Ser Gln Thr Gly Pro Lys Glu 
        515                 520                 525


Lys Pro Phe Gln Lys Pro Arg Ser Leu Asp Ser Ser Arg Ile Phe Asp 
    530                 535                 540


Gly Lys Ala Lys Glu Pro Tyr Ala Glu Gln Pro Asn Asp Lys Met Glu 
545                 550                 555                 560


Ala Glu Ser Ile Tyr Ile Asn Asp Pro Thr Val Lys Pro Ile Asn Asp 
                565                 570                 575


Asp Phe Arg Gly His Leu Phe Ser His Pro Gln Gln Ser Met Leu Gln 
            580                 585                 590


Asn Asp Gly Lys Cys Cys Pro Phe Met Glu Ser Met Leu Arg Tyr Glu 
        595                 600                 605


Val Tyr Gly Gly Glu Asn Glu Val Ile Pro Glu Val Leu Arg Lys Ser 
    610                 615                 620


His Ser His Phe Asp Lys Leu Gly Glu Thr Lys Gln Thr Pro His Ser 
625                 630                 635                 640


Leu Pro Ser Arg Gly Ala Ser Phe Ser Asp Arg Thr Pro Ser Ala Cys 
                645                 650                 655


Arg Leu Val Asp Asn Thr Ile His Gln Phe Gln Asn Leu Gly Leu Leu 
            660                 665                 670


Asp Tyr Pro Val Gly Val Asn Pro Leu Arg Gln Ala Ala Arg Gln Asp 
        675                 680                 685


Lys Asp Ser Glu Glu Leu Leu Arg Lys Gly Phe Val Gln Asp Ala Glu 
    690                 695                 700


Thr Thr Ser Leu Glu Asn Glu Gln Leu Ser Asn Asp Asp Gln Ala Leu 
705                 710                 715                 720


Tyr Gln Asn Glu Val Glu Asp Asp Asp Gly Ala Cys Ser Ser Leu Tyr 
                725                 730                 735


Leu Glu Glu Asp Asp Ile Ser Glu Asn Asp Asp Leu Arg Gln Met Leu 
            740                 745                 750


Pro Gly His Ser Gln Tyr Ser Phe Thr Gly Gly Ser Gln Gly Asn His 
        755                 760                 765


Leu Gly Lys Gln Lys Val Ile Glu Arg Ser Leu Thr Glu Tyr Asn Ser 
    770                 775                 780


Thr Met Glu Arg Val Glu Ser Gln Val Leu Lys Arg Asn Glu Cys Tyr 
785                 790                 795                 800


Lys Pro Thr Gly Leu His Ala Thr Pro Gly Glu Ser Gln Glu Pro Asn 
                805                 810                 815


Leu Ser Ala Glu Ser Cys Gly Leu Asn Ser Gly Ala Gln Phe Gly Phe 
            820                 825                 830


Asn Tyr Glu Glu Glu Pro Ser Val Ala Lys Cys Val Gln Ala Ser Ala 
        835                 840                 845


Pro Ala Asp Glu Arg Ile Phe Asp Tyr Tyr Ser Ala Arg Lys Ala Ser 
    850                 855                 860


Phe Glu Ala Glu Val Ile Gln Asp Thr Ile Gly Asp Thr Gly Lys Lys 
865                 870                 875                 880


Pro Ala Ser Trp Ser Gln Ser Pro Gln Asn Gln Glu Met Arg Lys His 
                885                 890                 895


Phe Pro Gln Lys Phe Gln Leu Phe Asn Thr Ser His Met Pro Val Leu 
            900                 905                 910


Ala Gln Asp Val Gln Tyr Glu His Ser His Leu Glu Gly Thr Glu Asn 
        915                 920                 925


His Ser Met Ala Gly Asp Ser Gly Ile Asp Ser Pro Arg Thr Gln Ser 
    930                 935                 940


Leu Gly Ser Asn Asn Ser Val Ile Leu Asp Gly Leu Lys Arg Arg Gln 
945                 950                 955                 960


Asn Phe Leu Gln Asn Val Glu Gly Thr Lys Ser Ser Gln Pro Leu Thr 
                965                 970                 975


Ser Asn Ser Leu Leu Pro Leu Thr Pro Val Ile Asn Val 
            980                 985


<210>  774
<211>  1450
<212>  DNA
<213>  Homo sapiens

<400>  774
cgaaaaagaa gcagtcctgg gctgtacccg gcgcagctgg gagcggctgc ttcctccggg     60

gtcgtatctc cgcccggcat ggggctgctg gacctttgcg aggaagtgtt cggcaccgcc    120

gacctttacc gggtgctggg cgtgcgacgc gaggcctccg acggcgaggt ccgacgaggc    180

taccacaagg tgtccctgca ggtacacccg gaccgggtgg gcgagggcga caaggaggac    240

gccacccgcc gcttccagat cctgggaaaa gtctattccg ttctcagtga cagagaacag    300

agagcagtgt acgatgagca gggaacagtg gacgaggact ctcctgtgct cacccaagac    360

cgagactggg aggcgtattg gcggctactc tttaaaaaga tatctttaga ggacattcaa    420

gcttttgaaa agacatacaa aggttcggaa gaagagctgg ctgatattaa gcaggcctat    480

ctggacttca agggtgacat ggatcagatc atggagtctg tgctttgcgt gcagtacaca    540

gaggaaccca ggataaggaa tatcattcag caagctattg acgccggaga ggtcccatcc    600

tataatgcct ttgtcaaaga atcgaaacaa aagatgaatg caaggaaaag gagggctcag    660

gaagaggcca aagaagcaga aatgagcaga aaggagttgg ggcttgatga aggcgtggat    720

agcctgaagg cagccattca gagcagacaa aaggatcggc aaaaggaaat ggacaatttt    780

ctggctcaga tggaagcaaa gtactgcaaa tcttccaaag gaggagggaa aaaatctgct    840

ctcaagaaag aaaagaaata atggaatttt tctcttcaaa ggtccttagg tgtaaattga    900

tgccatcgta ggcaaggtgc aggcaagatt tgaaggcaaa agtcaattca gctcttgaga    960

aaaggtgtct ttccagcctg aatttttcag attgactaga ccaagcagaa tctctcaacc   1020

tgatcttagt atttcctaga aagcacttga cattgtgtga ggtctcacct gaaggaactt   1080

ggtggtgaca tttgggaggg tggagggagg cagtgtcctt cctgacagca cttgcctcca   1140

tggatcttct gtacacagaa ctcttatcta ggatgtggtt ctgttcatgc tgctttctgc   1200

gatgtgcgtg tctgttagaa taggctctct acccagctag aacaccttcc agacacttgc   1260

tggacagcta tcttccacat acttcccagt ttacatttgg tcttaatgat cttgaataga   1320

tcctctcttc attttactca gccaggtttt gtactgatgt acaggtgtta aattacttca   1380

agcatttttg taagaggtgt atataattca ataaaaaagg taagacatga tgattaaaaa   1440

aaaaaaaaaa                                                          1450


<210>  775
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  775

Met Gly Leu Leu Asp Leu Cys Glu Glu Val Phe Gly Thr Ala Asp Leu 
1               5                   10                  15


Tyr Arg Val Leu Gly Val Arg Arg Glu Ala Ser Asp Gly Glu Val Arg 
            20                  25                  30


Arg Gly Tyr His Lys Val Ser Leu Gln Val His Pro Asp Arg Val Gly 
        35                  40                  45


Glu Gly Asp Lys Glu Asp Ala Thr Arg Arg Phe Gln Ile Leu Gly Lys 
    50                  55                  60


Val Tyr Ser Val Leu Ser Asp Arg Glu Gln Arg Ala Val Tyr Asp Glu 
65                  70                  75                  80


Gln Gly Thr Val Asp Glu Asp Ser Pro Val Leu Thr Gln Asp Arg Asp 
                85                  90                  95


Trp Glu Ala Tyr Trp Arg Leu Leu Phe Lys Lys Ile Ser Leu Glu Asp 
            100                 105                 110


Ile Gln Ala Phe Glu Lys Thr Tyr Lys Gly Ser Glu Glu Glu Leu Ala 
        115                 120                 125


Asp Ile Lys Gln Ala Tyr Leu Asp Phe Lys Gly Asp Met Asp Gln Ile 
    130                 135                 140


Met Glu Ser Val Leu Cys Val Gln Tyr Thr Glu Glu Pro Arg Ile Arg 
145                 150                 155                 160


Asn Ile Ile Gln Gln Ala Ile Asp Ala Gly Glu Val Pro Ser Tyr Asn 
                165                 170                 175


Ala Phe Val Lys Glu Ser Lys Gln Lys Met Asn Ala Arg Lys Arg Arg 
            180                 185                 190


Ala Gln Glu Glu Ala Lys Glu Ala Glu Met Ser Arg Lys Glu Leu Gly 
        195                 200                 205


Leu Asp Glu Gly Val Asp Ser Leu Lys Ala Ala Ile Gln Ser Arg Gln 
    210                 215                 220


Lys Asp Arg Gln Lys Glu Met Asp Asn Phe Leu Ala Gln Met Glu Ala 
225                 230                 235                 240


Lys Tyr Cys Lys Ser Ser Lys Gly Gly Gly Lys Lys Ser Ala Leu Lys 
                245                 250                 255


Lys Glu Lys Lys 
            260


<210>  776
<211>  2651
<212>  DNA
<213>  Homo sapiens

<400>  776
attgtgggaa gtatagggcg gcaagcggag gaggcgtggc gagcggatca tccgcttccg     60

gagtcgaggt tttcgggctt gtaccgcttg gcggtgcggc ctggtgtcgg cttgcaggtt    120

ctttctgtgt ttgttctctg ccctgccaag gccgtagagc tggtgcgtgc gggtagcggg    180

gctctccgag gagccgcacg ccggcggcac catggtccac ctcactactc tcctctgcaa    240

ggcctaccgt gggggccact taaccatccg ccttgccctg ggtggctgca ccaatcggcc    300

gttctaccgc attgtggctg ctcacaacaa gtgtcccagg gatggccgtt tcgtagagca    360

gctgggctcc tatgatccat tgcccaacag tcatggagaa aaactcgttg ccctcaacct    420

agacaggatc cgtcattgga ttggctgcgg ggcccacctc tctaagccta tggaaaagct    480

tctgggtctt gctggctttt tccctctgca tcctatgatg atcacaaatg ctgagagact    540

gcgaaggaaa cgggcacgtg aagtcctgtt agcttctcag aaaacagatg cagaagctac    600

agatacagag gctacagaaa cataaatgag ctgactttag tgagcatagc agtgggaaca    660

aggtcaaggt ccttttgaaa cactgcagcg atcttaattt tgttagattt ggagttcaat    720

aaatggagta tcctgagttg cccttgctct tctggcctgg cctgcacagg gcccagggag    780

agatttgttc ttgtgtgact tagagctggg tgtgggtact aattagcttt tttcgacttt    840

gtcttgggat agacagtggc tatgggagga ttggactttt gagttgggct ctgggtctct    900

tggacaactt tacaatttac tggcttccaa gacttcctgc ttcaaaaccc ccagccagac    960

tattcatggc ccattcagat cttcatgttc atcccacaag tgcaagaaca gttaaccttt   1020

cttaattgat ttttgtaatt ggaggtttat attgtcttgc ctaatgcata ttctcttttt   1080

tttttttttt ttgagacgga gtcttgttct gttgccaggc tggagtgcgg tggtgcaatc   1140

tcagctcact gcaatctcca cctcctgggt tcaagaggtt ctcctgcctc agcctcctga   1200

gtagccgggg agctacaagc atgcaccacc acacccagct aatttttttt ttttttttga   1260

gaggagtctc gctctgtcgc ccaggcttga gtgcagtggc gcgatctcgg ctcactgcaa   1320

gctctgtctc ctgggttcat gccattctcc tgcttcagcc tcccgagtag tcccaggagt   1380

agctgggact acaggtgccc accaccacac ccagctaatt tttttgtatt tttagtagag   1440

atggggtttc accatgttat ccaggatggt tttgatctcc tgacctcgtg atccgcccgc   1500

cttggcctcc caaaagtgct gggattatag gcgtgagcca ccgcccgggc aaatttttgt   1560

atttttagta gagatggggt ttcaccgtgt tggccaggat ggtctcaatc tgaccttgtg   1620

atctgcccac ctcggcctcc caaagtgcta ggattactgg cgtgagccac cactcctagc   1680

cttaatgcat attcttaaat atacaaaggt agatttgtta tgaaaattgc tttggggctc   1740

taataaccta ccttttaaga atgagaaact gctgggctta agggagttca gtatgaatca   1800

agattgaacc attcaaatgt ggctgtgatt tctgcatata tcatagatgg gatccttctg   1860

agaatactgg aatagggaat taggacacca agccaattca gctgtgaacc ttattcttgt   1920

acttttcttt cttgctggta attttatgga gcaggttaag aaggctgctc tgtgttagga   1980

taaactgtat accaataatg ttgacaacct gtaatgagtg ttgcatttta cttcttgtat   2040

cttttccttc ctaccttgat gccagtaatc tataagggat ctttatagtt tgaatgtatt   2100

tgaataactt cagtatactt tagttctact tttttatttg actcacaacc attcttaggt   2160

ctcaagtatt cccatgtgtt ttaaaagcct gaagtcagtg agatgaaatt caacatcaag   2220

aatttgaagt aacttgtaag gaaaaataat ataaagatac cattggggca gtggctcaca   2280

cctgtaatct cagcactttg ggaggctgag gtggaaggat cacttgaagc cagagtttga   2340

gaccagcctg tgcaacacag caagaccccg tctctacaaa aacttaaaaa attagctggc   2400

tgtggtgttg ctcacccata gttccagcta ctcgggaagc tgaggcagta agatcacttg   2460

agcccaggag gccgatgctg cagtgaactg tgattgttcc actacagtcc agcctgggtg   2520

acagagaaaa gaaaaagaaa acattacata atttggctag agcataataa tttgattttc   2580

tggtttttga aaatttgagt tgcaataaaa ggatatttca gtgtgcgatt tcaaaaaaaa   2640

aaaaaaaaaa a                                                        2651


<210>  777
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  777

Met Val His Leu Thr Thr Leu Leu Cys Lys Ala Tyr Arg Gly Gly His 
1               5                   10                  15


Leu Thr Ile Arg Leu Ala Leu Gly Gly Cys Thr Asn Arg Pro Phe Tyr 
            20                  25                  30


Arg Ile Val Ala Ala His Asn Lys Cys Pro Arg Asp Gly Arg Phe Val 
        35                  40                  45


Glu Gln Leu Gly Ser Tyr Asp Pro Leu Pro Asn Ser His Gly Glu Lys 
    50                  55                  60


Leu Val Ala Leu Asn Leu Asp Arg Ile Arg His Trp Ile Gly Cys Gly 
65                  70                  75                  80


Ala His Leu Ser Lys Pro Met Glu Lys Leu Leu Gly Leu Ala Gly Phe 
                85                  90                  95


Phe Pro Leu His Pro Met Met Ile Thr Asn Ala Glu Arg Leu Arg Arg 
            100                 105                 110


Lys Arg Ala Arg Glu Val Leu Leu Ala Ser Gln Lys Thr Asp Ala Glu 
        115                 120                 125


Ala Thr Asp Thr Glu Ala Thr Glu Thr 
    130                 135


<210>  778
<211>  3707
<212>  DNA
<213>  Homo sapiens

<400>  778
agcgtctcgc tccctgctcc cggccccaga gggttatcgc gagtcttgga ataaacttgc     60

tcgtgcgatg gccaaaaaga ccaaagaaaa cagagggact tttcccagtt ggtgatatgg    120

agcaagtgcc atcagcaggc agactcgtgc agatcaccgt gacagaggga tatgatttga    180

aaggttttaa aggagatact ccagttacct ttattcgagc agaattcaat caagtggttc    240

tgggagactc tgcaaaaatt actgtttctc cagaaggaag tgcaaaatac aacttcacta    300

gcagttttga gtttaatcct gaaggaggaa tcacttcaga tgacctcgct cacaaacctg    360

tgttcttaac tgtgactgaa gttttaccaa aggaaaagaa acagaaagaa gagaagacct    420

taattcttgg tcaggctgtg gtggaccttc ttcccttact ggaaggacag agttcatttc    480

aaacaacagt tccattgcac cctgtgcaag gctcaccctt agaaactcct agatcaagtg    540

ctaagcagtg cagtcttgaa gttaaagtat tagtggcaga gcctttactg accacagccc    600

agatctcagg gggcaatcta ctgaaggtca cgttggaggc tgcttactct gtgcctgaat    660

ccttcattcc aacaggtcct gggcagaact acatggtcgg tctgcaagtt ccatcacttg    720

gagagaagga ctatcccatt ttatttaaga atggaactct gaagcttgga ggggaaaggg    780

aacctgttcc ccggcccaaa aagtggccaa ttgccaacat tctggctcca ggagctaata    840

acattcctga tgcattcatt gttggtggtc cctatgaaga agaagaagga gaactcaacc    900

atcctgagga cagcgaattt aggaatcaag cagagtgcat aaagaaaagg attatttggg    960

acttggaaag tcgctgctac cttgatcctt ctgcagtggt cagttttcag aagcgaattg   1020

ccgattgccg gctttggcct gtagagatca caagagttcc tctggtcact atacccaaag   1080

ggaaagctgg caaaactgaa aagactgatg aagaagctca gctttcgttt catggtgtgg   1140

cttatgttaa tatggtccca ttgttgtatc caggtgtgaa gagaattcgg ggagcttttc   1200

atgtttaccc ttacctagac agtgtagtcc atgaaaagac caaatgttta ttgagcttgt   1260

tccgggatat tggccatcac ttgattcata ataataaaat aggaggaatt aattctctgc   1320

tgtccaaaca agctgtttct aagaatctga aagaagataa accagtgaaa gaaaaggata   1380

tagatggaag gcctaggcct ggggatgtgc aggcacctag tataaaatct cagagctcag   1440

atactccttt ggaaggtgaa ccccctctaa gtcacaatcc tgaaggacag caatatgtag   1500

aagcagggac atacattgtg ttggaaattc agttggacaa agccttggtt ccaaagcgaa   1560

tgccagagga gctagccaga agggtcaagg aaatgattcc tccaaggcct cctcttaccc   1620

gtcggacagg aggagctcag aaggcagtga gtgactacca catacagatc aagaatattt   1680

ctagagccat tctagatgaa tactacagaa tgtttggaaa acaggtggcc aaactggaga   1740

gtgatatgga tagtgaaacc ttggaggagc agaagtgcca gctcagctat gaacttaatt   1800

gctctggaaa atactttgct ttcaaagaac aactcaagca tgctgtggta aagattgtga   1860

gagataaata cttgaagaca acatcatttg aaagccagga ggaacttcag acatttatca   1920

gtgagctcta tgtgttctta gtagatcaga tgcatgtagc cctaaaccag accatgccag   1980

atgatgtcca aggcactgtt gcaaccattt atacaagcag tgaacagctt caactctttg   2040

catttgaagc agaagtcaat gagaactttg agatggcagc agcatattat aaagagagat   2100

tggtccgtga gccccagaat ctggatcact ggttggacta tggtgccttc tgcctcctaa   2160

ctgaagacaa catcaaagca caagagtgtt ttcagaaagc cctttccctc aaccagagtc   2220

atatccacag cttgttgctg tgtggtgtcc tggctgtcct gttggagaac tatgagcaag   2280

cagaaatttt ctttgaggat gctacttgct tggaaccaac taatgttgta gcctggactt   2340

tacttggttt gtactatgaa attcaaaaca atgatattcg aatggaaatg gcatttcatg   2400

aggcctccaa acagcttcag gcacggatgc ttcaggcaca agtaacaaag caaaagagca   2460

ctggtgtaga agacactgag gaaagaggga agagagaatc tagtttaggc ccttggggaa   2520

tcacaaatgg ttctgcaaca gcaatcaagg tggaagcccc agcaggacca ggagctgcat   2580

tatctattct agacaaattt cttgaagaat cctccaaact gcagtctgat tcacaagaac   2640

ccattttgac tacacaaact tgggatccaa gtataagcca aaaaccatct aacacattta   2700

tcaaggagat accaacaaag aaagaagcat caaaatgtca agattcatca gctcttctgc   2760

atcccggcct tcattatggt gtttctcaaa ctaccaccat cttcatggag accatacatt   2820

tcttgatgaa agtcaaggct gtgcagtatg tgcacagagt gcttgcacat gagctgttat   2880

gccctcaagg aggccccagc tgtgaatatt acttggtgct ggcccaaaca cacattctta   2940

agaagaactt tgccaaggca gaggaatacc ttcaacaagc agcccagatg gactacctga   3000

accccaatgt ctggggcctg aagggccatc tctattttct gagtggaaat cattctgagg   3060

ccaaggcatg ctatgaacga accattagct ttgtagtgga tgcttctgag atgcacttca   3120

tcttcctgag actggggctc atctatctgg aagagaaaga gtatgaaaag gcaaagaaaa   3180

cctatatgca agcctgtaag agatcacctt catgccttac ctggctagga ctgggaatcg   3240

cctgctatcg gctggaggag ctcacagagg ctgaggatgc tctttctgaa gccaatgcat   3300

tgaacaacta caatgctgaa gtatgggcat atctggctct ggtctgcctg aaagttggac   3360

ggcaattaga agctgagcag gcctacaagt acatgatcaa gctgaaattg aaagatgagg   3420

ctctgcttgc agagatccac acactacagg aaacagttgg ctttggaaat ccatctttct   3480

gatacccctc cagctgaaca attttctgca tgggactctg agttcctttc cttcccagag   3540

agttttaccg tatgaagcct ggagctggag aacgaaagaa tcttcactat aaacagagac   3600

ccattcattt atttccattg gctgtgttac tggatgtttt actggttgac gagaaactgg   3660

gtcacaataa aaaaatggag atatgaaact caaaaaaaaa aaaaaaa                 3707


<210>  779
<211>  1121
<212>  PRT
<213>  Homo sapiens

<400>  779

Met Glu Gln Val Pro Ser Ala Gly Arg Leu Val Gln Ile Thr Val Thr 
1               5                   10                  15


Glu Gly Tyr Asp Leu Lys Gly Phe Lys Gly Asp Thr Pro Val Thr Phe 
            20                  25                  30


Ile Arg Ala Glu Phe Asn Gln Val Val Leu Gly Asp Ser Ala Lys Ile 
        35                  40                  45


Thr Val Ser Pro Glu Gly Ser Ala Lys Tyr Asn Phe Thr Ser Ser Phe 
    50                  55                  60


Glu Phe Asn Pro Glu Gly Gly Ile Thr Ser Asp Asp Leu Ala His Lys 
65                  70                  75                  80


Pro Val Phe Leu Thr Val Thr Glu Val Leu Pro Lys Glu Lys Lys Gln 
                85                  90                  95


Lys Glu Glu Lys Thr Leu Ile Leu Gly Gln Ala Val Val Asp Leu Leu 
            100                 105                 110


Pro Leu Leu Glu Gly Gln Ser Ser Phe Gln Thr Thr Val Pro Leu His 
        115                 120                 125


Pro Val Gln Gly Ser Pro Leu Glu Thr Pro Arg Ser Ser Ala Lys Gln 
    130                 135                 140


Cys Ser Leu Glu Val Lys Val Leu Val Ala Glu Pro Leu Leu Thr Thr 
145                 150                 155                 160


Ala Gln Ile Ser Gly Gly Asn Leu Leu Lys Val Thr Leu Glu Ala Ala 
                165                 170                 175


Tyr Ser Val Pro Glu Ser Phe Ile Pro Thr Gly Pro Gly Gln Asn Tyr 
            180                 185                 190


Met Val Gly Leu Gln Val Pro Ser Leu Gly Glu Lys Asp Tyr Pro Ile 
        195                 200                 205


Leu Phe Lys Asn Gly Thr Leu Lys Leu Gly Gly Glu Arg Glu Pro Val 
    210                 215                 220


Pro Arg Pro Lys Lys Trp Pro Ile Ala Asn Ile Leu Ala Pro Gly Ala 
225                 230                 235                 240


Asn Asn Ile Pro Asp Ala Phe Ile Val Gly Gly Pro Tyr Glu Glu Glu 
                245                 250                 255


Glu Gly Glu Leu Asn His Pro Glu Asp Ser Glu Phe Arg Asn Gln Ala 
            260                 265                 270


Glu Cys Ile Lys Lys Arg Ile Ile Trp Asp Leu Glu Ser Arg Cys Tyr 
        275                 280                 285


Leu Asp Pro Ser Ala Val Val Ser Phe Gln Lys Arg Ile Ala Asp Cys 
    290                 295                 300


Arg Leu Trp Pro Val Glu Ile Thr Arg Val Pro Leu Val Thr Ile Pro 
305                 310                 315                 320


Lys Gly Lys Ala Gly Lys Thr Glu Lys Thr Asp Glu Glu Ala Gln Leu 
                325                 330                 335


Ser Phe His Gly Val Ala Tyr Val Asn Met Val Pro Leu Leu Tyr Pro 
            340                 345                 350


Gly Val Lys Arg Ile Arg Gly Ala Phe His Val Tyr Pro Tyr Leu Asp 
        355                 360                 365


Ser Val Val His Glu Lys Thr Lys Cys Leu Leu Ser Leu Phe Arg Asp 
    370                 375                 380


Ile Gly His His Leu Ile His Asn Asn Lys Ile Gly Gly Ile Asn Ser 
385                 390                 395                 400


Leu Leu Ser Lys Gln Ala Val Ser Lys Asn Leu Lys Glu Asp Lys Pro 
                405                 410                 415


Val Lys Glu Lys Asp Ile Asp Gly Arg Pro Arg Pro Gly Asp Val Gln 
            420                 425                 430


Ala Pro Ser Ile Lys Ser Gln Ser Ser Asp Thr Pro Leu Glu Gly Glu 
        435                 440                 445


Pro Pro Leu Ser His Asn Pro Glu Gly Gln Gln Tyr Val Glu Ala Gly 
    450                 455                 460


Thr Tyr Ile Val Leu Glu Ile Gln Leu Asp Lys Ala Leu Val Pro Lys 
465                 470                 475                 480


Arg Met Pro Glu Glu Leu Ala Arg Arg Val Lys Glu Met Ile Pro Pro 
                485                 490                 495


Arg Pro Pro Leu Thr Arg Arg Thr Gly Gly Ala Gln Lys Ala Val Ser 
            500                 505                 510


Asp Tyr His Ile Gln Ile Lys Asn Ile Ser Arg Ala Ile Leu Asp Glu 
        515                 520                 525


Tyr Tyr Arg Met Phe Gly Lys Gln Val Ala Lys Leu Glu Ser Asp Met 
    530                 535                 540


Asp Ser Glu Thr Leu Glu Glu Gln Lys Cys Gln Leu Ser Tyr Glu Leu 
545                 550                 555                 560


Asn Cys Ser Gly Lys Tyr Phe Ala Phe Lys Glu Gln Leu Lys His Ala 
                565                 570                 575


Val Val Lys Ile Val Arg Asp Lys Tyr Leu Lys Thr Thr Ser Phe Glu 
            580                 585                 590


Ser Gln Glu Glu Leu Gln Thr Phe Ile Ser Glu Leu Tyr Val Phe Leu 
        595                 600                 605


Val Asp Gln Met His Val Ala Leu Asn Gln Thr Met Pro Asp Asp Val 
    610                 615                 620


Gln Gly Thr Val Ala Thr Ile Tyr Thr Ser Ser Glu Gln Leu Gln Leu 
625                 630                 635                 640


Phe Ala Phe Glu Ala Glu Val Asn Glu Asn Phe Glu Met Ala Ala Ala 
                645                 650                 655


Tyr Tyr Lys Glu Arg Leu Val Arg Glu Pro Gln Asn Leu Asp His Trp 
            660                 665                 670


Leu Asp Tyr Gly Ala Phe Cys Leu Leu Thr Glu Asp Asn Ile Lys Ala 
        675                 680                 685


Gln Glu Cys Phe Gln Lys Ala Leu Ser Leu Asn Gln Ser His Ile His 
    690                 695                 700


Ser Leu Leu Leu Cys Gly Val Leu Ala Val Leu Leu Glu Asn Tyr Glu 
705                 710                 715                 720


Gln Ala Glu Ile Phe Phe Glu Asp Ala Thr Cys Leu Glu Pro Thr Asn 
                725                 730                 735


Val Val Ala Trp Thr Leu Leu Gly Leu Tyr Tyr Glu Ile Gln Asn Asn 
            740                 745                 750


Asp Ile Arg Met Glu Met Ala Phe His Glu Ala Ser Lys Gln Leu Gln 
        755                 760                 765


Ala Arg Met Leu Gln Ala Gln Val Thr Lys Gln Lys Ser Thr Gly Val 
    770                 775                 780


Glu Asp Thr Glu Glu Arg Gly Lys Arg Glu Ser Ser Leu Gly Pro Trp 
785                 790                 795                 800


Gly Ile Thr Asn Gly Ser Ala Thr Ala Ile Lys Val Glu Ala Pro Ala 
                805                 810                 815


Gly Pro Gly Ala Ala Leu Ser Ile Leu Asp Lys Phe Leu Glu Glu Ser 
            820                 825                 830


Ser Lys Leu Gln Ser Asp Ser Gln Glu Pro Ile Leu Thr Thr Gln Thr 
        835                 840                 845


Trp Asp Pro Ser Ile Ser Gln Lys Pro Ser Asn Thr Phe Ile Lys Glu 
    850                 855                 860


Ile Pro Thr Lys Lys Glu Ala Ser Lys Cys Gln Asp Ser Ser Ala Leu 
865                 870                 875                 880


Leu His Pro Gly Leu His Tyr Gly Val Ser Gln Thr Thr Thr Ile Phe 
                885                 890                 895


Met Glu Thr Ile His Phe Leu Met Lys Val Lys Ala Val Gln Tyr Val 
            900                 905                 910


His Arg Val Leu Ala His Glu Leu Leu Cys Pro Gln Gly Gly Pro Ser 
        915                 920                 925


Cys Glu Tyr Tyr Leu Val Leu Ala Gln Thr His Ile Leu Lys Lys Asn 
    930                 935                 940


Phe Ala Lys Ala Glu Glu Tyr Leu Gln Gln Ala Ala Gln Met Asp Tyr 
945                 950                 955                 960


Leu Asn Pro Asn Val Trp Gly Leu Lys Gly His Leu Tyr Phe Leu Ser 
                965                 970                 975


Gly Asn His Ser Glu Ala Lys Ala Cys Tyr Glu Arg Thr Ile Ser Phe 
            980                 985                 990


Val Val Asp Ala Ser Glu Met His Phe Ile Phe Leu Arg Leu Gly Leu 
        995                 1000                1005


Ile Tyr Leu Glu Glu Lys Glu Tyr Glu Lys Ala Lys Lys Thr Tyr Met 
    1010                1015                1020


Gln Ala Cys Lys Arg Ser Pro Ser Cys Leu Thr Trp Leu Gly Leu Gly 
1025                1030                1035                1040


Ile Ala Cys Tyr Arg Leu Glu Glu Leu Thr Glu Ala Glu Asp Ala Leu 
                1045                1050                1055


Ser Glu Ala Asn Ala Leu Asn Asn Tyr Asn Ala Glu Val Trp Ala Tyr 
            1060                1065                1070


Leu Ala Leu Val Cys Leu Lys Val Gly Arg Gln Leu Glu Ala Glu Gln 
        1075                1080                1085


Ala Tyr Lys Tyr Met Ile Lys Leu Lys Leu Lys Asp Glu Ala Leu Leu 
    1090                1095                1100


Ala Glu Ile His Thr Leu Gln Glu Thr Val Gly Phe Gly Asn Pro Ser 
1105                1110                1115                1120


Phe 



<210>  780
<211>  2110
<212>  DNA
<213>  Homo sapiens

<400>  780
gaacccggtc tcccgcaaga tggagccggg ttgggctgtg acgctgctgc tggggtcaga     60

atgtcatacc caggctatcc cccaacaggc tacccacctt tccctggata tcctcctgca    120

ggtcaggagt catcttttcc cccttctggt cagtatcctt atcctagtgg ctttcctcca    180

atgggaggag gtgcctaccc acaagtgcca agtagtggct acccaggagc tggaggctac    240

cctgcgcctg gaggttatcc agcccctgga ggctatcctg gtgccccaca gccaggggga    300

gctccatcct atcccggagt tcctccaggc caaggatttg gagtcccacc aggtggagca    360

ggcttttctg ggtatccaca gccaccttca cagtcttatg gaggtggtcc agcacaggtt    420

ccactacctg gtggctttcc tggaggacag atgccttctc agtatcctgg aggacaacct    480

acttacccta gtcagcctgc cacagtgact caggtcactc aaggaactat ccgaccagct    540

gccaacttcg atgctataag agatgcagaa attcttcgta aggcaatgaa gggttttggg    600

acagatgagc aggcaattgt ggatgtggtg gccaaccgtt ccaatgatca gaggcaaaaa    660

attaaagcag catttaagac ctcctatggc aaggatttaa tcaaagatct caaatcagag    720

ttaagtggaa atatggaaga actgatcctg gccctcttca tgcctcctac gtattacgat    780

gcctggagct tacggaaagc aatgcaggga gcaggaactc aggaacgtgt attgattgag    840

attttgtgca caagaacaaa tcaggaaatc cgagaaattg tcagatgtta tcagtcagaa    900

tttggacgag accttgaaaa ggacattagg tcagatacat caggacattt tgaacgttta    960

cttgtgtcca tgtgccaggg aaatcgtgat gagaaccaga gtataaacca ccaaatggct   1020

caggaagatg ctcagcgtct ctatcaagct ggtgagggga gactagggac cgatgaatct   1080

tgctttaaca tgatccttgc cacaagaagc tttcctcagc tgagagctac catggaggct   1140

tattctagga tggctaatcg agacttgtta agcagtgtga gccgtgagtt ttccggatat   1200

gtagaaagtg gtttgaagac catcttgcag tgtgccctga accgccctgc cttctttgct   1260

gagaggctct actatgctat gaaaggtgct ggcacagatg actccaccct ggtccggatt   1320

gtggtcactc gaagtgagat tgaccttgta caaataaaac agatgttcgc tcagatgtat   1380

cagaagactc tgggcacaat gattgcaggt gacacgagtg gagattaccg aagacttctt   1440

ctggctattg tgggccagta ggagggattt tttttttttt aatgaaaaaa aaatttctat   1500

tcatagctta tccttcagag caatgacctg catgcagcaa tatcaaacat cagctaaccg   1560

aaagagcttt ctgtcaagga ccgtatcagg gtaatgtgct tggtttgcac atgttgttat   1620

tgccttaatt ctaattttat tttgttctct acatacaatc aatgtaaagc catatcacaa   1680

tgatacagta atattgcaat gtttgtaaac cttcattctt actagtttca ttctaatcaa   1740

gatgtcaaat tgaataaaaa tcacagcaat ctctgattct gtgtaataat attgaataat   1800

tttttagaag gttactgaaa gctctgcctt ccggaatccc tctaagtctg cttgatagag   1860

tggatagtat gttaaaactg tgtactttaa aaaaaaattc aacctttaca tctagaataa   1920

tttgcatctc attttgccta aattggttct gtattcataa acactttcca catagaaaat   1980

agattagtat tacctgtggc accttttaag aaagggtcaa atgtttatat gcttaagata   2040

catagcctcc ctttttttcg cgttgtttcc tttttttaaa ttgagttatg acaaataaaa   2100

aattgcatat                                                          2110


<210>  781
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  781

Met Ser Tyr Pro Gly Tyr Pro Pro Thr Gly Tyr Pro Pro Phe Pro Gly 
1               5                   10                  15


Tyr Pro Pro Ala Gly Gln Glu Ser Ser Phe Pro Pro Ser Gly Gln Tyr 
            20                  25                  30


Pro Tyr Pro Ser Gly Phe Pro Pro Met Gly Gly Gly Ala Tyr Pro Gln 
        35                  40                  45


Val Pro Ser Ser Gly Tyr Pro Gly Ala Gly Gly Tyr Pro Ala Pro Gly 
    50                  55                  60


Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Gly Ala Pro Gln Pro Gly Gly 
65                  70                  75                  80


Ala Pro Ser Tyr Pro Gly Val Pro Pro Gly Gln Gly Phe Gly Val Pro 
                85                  90                  95


Pro Gly Gly Ala Gly Phe Ser Gly Tyr Pro Gln Pro Pro Ser Gln Ser 
            100                 105                 110


Tyr Gly Gly Gly Pro Ala Gln Val Pro Leu Pro Gly Gly Phe Pro Gly 
        115                 120                 125


Gly Gln Met Pro Ser Gln Tyr Pro Gly Gly Gln Pro Thr Tyr Pro Ser 
    130                 135                 140


Gln Pro Ala Thr Val Thr Gln Val Thr Gln Gly Thr Ile Arg Pro Ala 
145                 150                 155                 160


Ala Asn Phe Asp Ala Ile Arg Asp Ala Glu Ile Leu Arg Lys Ala Met 
                165                 170                 175


Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Val Asp Val Val Ala Asn 
            180                 185                 190


Arg Ser Asn Asp Gln Arg Gln Lys Ile Lys Ala Ala Phe Lys Thr Ser 
        195                 200                 205


Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser Glu Leu Ser Gly Asn 
    210                 215                 220


Met Glu Glu Leu Ile Leu Ala Leu Phe Met Pro Pro Thr Tyr Tyr Asp 
225                 230                 235                 240


Ala Trp Ser Leu Arg Lys Ala Met Gln Gly Ala Gly Thr Gln Glu Arg 
                245                 250                 255


Val Leu Ile Glu Ile Leu Cys Thr Arg Thr Asn Gln Glu Ile Arg Glu 
            260                 265                 270


Ile Val Arg Cys Tyr Gln Ser Glu Phe Gly Arg Asp Leu Glu Lys Asp 
        275                 280                 285


Ile Arg Ser Asp Thr Ser Gly His Phe Glu Arg Leu Leu Val Ser Met 
    290                 295                 300


Cys Gln Gly Asn Arg Asp Glu Asn Gln Ser Ile Asn His Gln Met Ala 
305                 310                 315                 320


Gln Glu Asp Ala Gln Arg Leu Tyr Gln Ala Gly Glu Gly Arg Leu Gly 
                325                 330                 335


Thr Asp Glu Ser Cys Phe Asn Met Ile Leu Ala Thr Arg Ser Phe Pro 
            340                 345                 350


Gln Leu Arg Ala Thr Met Glu Ala Tyr Ser Arg Met Ala Asn Arg Asp 
        355                 360                 365


Leu Leu Ser Ser Val Ser Arg Glu Phe Ser Gly Tyr Val Glu Ser Gly 
    370                 375                 380


Leu Lys Thr Ile Leu Gln Cys Ala Leu Asn Arg Pro Ala Phe Phe Ala 
385                 390                 395                 400


Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp Ser Thr 
                405                 410                 415


Leu Val Arg Ile Val Val Thr Arg Ser Glu Ile Asp Leu Val Gln Ile 
            420                 425                 430


Lys Gln Met Phe Ala Gln Met Tyr Gln Lys Thr Leu Gly Thr Met Ile 
        435                 440                 445


Ala Gly Asp Thr Ser Gly Asp Tyr Arg Arg Leu Leu Leu Ala Ile Val 
    450                 455                 460


Gly Gln 
465


<210>  782
<211>  2176
<212>  DNA
<213>  Homo sapiens

<400>  782
gaacccggtc tcccgcaaga tggagccggg ttgggctgtg acgctgctgc tggggtcaga     60

atgtcatacc caggctatcc cccaacaggc tacccacctt tccctggata tcctcctgca    120

ggtcaggagt catcttttcc cccttctggt cagtatcctt atcctagtgg ctttcctcca    180

atgggaggag gtgcctaccc acaagtgcca agtagtggct acccaggagc tggaggctac    240

cctgcgcctg gaggttatcc agcccctgga ggctatcctg gtgccccaca gccaggggga    300

gctccatcct atcccggagt tcctccaggc caaggatttg gagtcccacc aggtggagca    360

ggcttttctg ggtatccaca gccaccttca cagtcttatg gaggtggtcc agcacaggtt    420

ccactacctg gtggctttcc tggaggacag atgccttctc agtatcctgg aggacaacct    480

acttacccta gtcagatcaa tacagattct ttttcttcct atcctgtttt ctctcctgtt    540

tctttggatt atagcagtga acctgccaca gtgactcagg tcactcaagg aactatccga    600

ccagctgcca acttcgatgc tataagagat gcagaaattc ttcgtaaggc aatgaagggt    660

tttgggacag atgagcaggc aattgtggat gtggtggcca accgttccaa tgatcagagg    720

caaaaaatta aagcagcatt taagacctcc tatggcaagg atttaatcaa agatctcaaa    780

tcagagttaa gtggaaatat ggaagaactg atcctggccc tcttcatgcc tcctacgtat    840

tacgatgcct ggagcttacg gaaagcaatg cagggagcag gaactcagga acgtgtattg    900

attgagattt tgtgcacaag aacaaatcag gaaatccgag aaattgtcag atgttatcag    960

tcagaatttg gacgagacct tgaaaaggac attaggtcag atacatcagg acattttgaa   1020

cgtttacttg tgtccatgtg ccagggaaat cgtgatgaga accagagtat aaaccaccaa   1080

atggctcagg aagatgctca gcgtctctat caagctggtg aggggagact agggaccgat   1140

gaatcttgct ttaacatgat ccttgccaca agaagctttc ctcagctgag agctaccatg   1200

gaggcttatt ctaggatggc taatcgagac ttgttaagca gtgtgagccg tgagttttcc   1260

ggatatgtag aaagtggttt gaagaccatc ttgcagtgtg ccctgaaccg ccctgccttc   1320

tttgctgaga ggctctacta tgctatgaaa ggtgctggca cagatgactc caccctggtc   1380

cggattgtgg tcactcgaag tgagattgac cttgtacaaa taaaacagat gttcgctcag   1440

atgtatcaga agactctggg cacaatgatt gcaggtgaca cgagtggaga ttaccgaaga   1500

cttcttctgg ctattgtggg ccagtaggag ggattttttt ttttttaatg aaaaaaaaat   1560

ttctattcat agcttatcct tcagagcaat gacctgcatg cagcaatatc aaacatcagc   1620

taaccgaaag agctttctgt caaggaccgt atcagggtaa tgtgcttggt ttgcacatgt   1680

tgttattgcc ttaattctaa ttttattttg ttctctacat acaatcaatg taaagccata   1740

tcacaatgat acagtaatat tgcaatgttt gtaaaccttc attcttacta gtttcattct   1800

aatcaagatg tcaaattgaa taaaaatcac agcaatctct gattctgtgt aataatattg   1860

aataattttt tagaaggtta ctgaaagctc tgccttccgg aatccctcta agtctgcttg   1920

atagagtgga tagtatgtta aaactgtgta ctttaaaaaa aaattcaacc tttacatcta   1980

gaataatttg catctcattt tgcctaaatt ggttctgtat tcataaacac tttccacata   2040

gaaaatagat tagtattacc tgtggcacct tttaagaaag ggtcaaatgt ttatatgctt   2100

aagatacata gcctcccttt ttttcgcgtt gtttcctttt tttaaattga gttatgacaa   2160

ataaaaaatt gcatat                                                   2176


<210>  783
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  783

Met Ser Tyr Pro Gly Tyr Pro Pro Thr Gly Tyr Pro Pro Phe Pro Gly 
1               5                   10                  15


Tyr Pro Pro Ala Gly Gln Glu Ser Ser Phe Pro Pro Ser Gly Gln Tyr 
            20                  25                  30


Pro Tyr Pro Ser Gly Phe Pro Pro Met Gly Gly Gly Ala Tyr Pro Gln 
        35                  40                  45


Val Pro Ser Ser Gly Tyr Pro Gly Ala Gly Gly Tyr Pro Ala Pro Gly 
    50                  55                  60


Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Gly Ala Pro Gln Pro Gly Gly 
65                  70                  75                  80


Ala Pro Ser Tyr Pro Gly Val Pro Pro Gly Gln Gly Phe Gly Val Pro 
                85                  90                  95


Pro Gly Gly Ala Gly Phe Ser Gly Tyr Pro Gln Pro Pro Ser Gln Ser 
            100                 105                 110


Tyr Gly Gly Gly Pro Ala Gln Val Pro Leu Pro Gly Gly Phe Pro Gly 
        115                 120                 125


Gly Gln Met Pro Ser Gln Tyr Pro Gly Gly Gln Pro Thr Tyr Pro Ser 
    130                 135                 140


Gln Ile Asn Thr Asp Ser Phe Ser Ser Tyr Pro Val Phe Ser Pro Val 
145                 150                 155                 160


Ser Leu Asp Tyr Ser Ser Glu Pro Ala Thr Val Thr Gln Val Thr Gln 
                165                 170                 175


Gly Thr Ile Arg Pro Ala Ala Asn Phe Asp Ala Ile Arg Asp Ala Glu 
            180                 185                 190


Ile Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile 
        195                 200                 205


Val Asp Val Val Ala Asn Arg Ser Asn Asp Gln Arg Gln Lys Ile Lys 
    210                 215                 220


Ala Ala Phe Lys Thr Ser Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys 
225                 230                 235                 240


Ser Glu Leu Ser Gly Asn Met Glu Glu Leu Ile Leu Ala Leu Phe Met 
                245                 250                 255


Pro Pro Thr Tyr Tyr Asp Ala Trp Ser Leu Arg Lys Ala Met Gln Gly 
            260                 265                 270


Ala Gly Thr Gln Glu Arg Val Leu Ile Glu Ile Leu Cys Thr Arg Thr 
        275                 280                 285


Asn Gln Glu Ile Arg Glu Ile Val Arg Cys Tyr Gln Ser Glu Phe Gly 
    290                 295                 300


Arg Asp Leu Glu Lys Asp Ile Arg Ser Asp Thr Ser Gly His Phe Glu 
305                 310                 315                 320


Arg Leu Leu Val Ser Met Cys Gln Gly Asn Arg Asp Glu Asn Gln Ser 
                325                 330                 335


Ile Asn His Gln Met Ala Gln Glu Asp Ala Gln Arg Leu Tyr Gln Ala 
            340                 345                 350


Gly Glu Gly Arg Leu Gly Thr Asp Glu Ser Cys Phe Asn Met Ile Leu 
        355                 360                 365


Ala Thr Arg Ser Phe Pro Gln Leu Arg Ala Thr Met Glu Ala Tyr Ser 
    370                 375                 380


Arg Met Ala Asn Arg Asp Leu Leu Ser Ser Val Ser Arg Glu Phe Ser 
385                 390                 395                 400


Gly Tyr Val Glu Ser Gly Leu Lys Thr Ile Leu Gln Cys Ala Leu Asn 
                405                 410                 415


Arg Pro Ala Phe Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala 
            420                 425                 430


Gly Thr Asp Asp Ser Thr Leu Val Arg Ile Val Val Thr Arg Ser Glu 
        435                 440                 445


Ile Asp Leu Val Gln Ile Lys Gln Met Phe Ala Gln Met Tyr Gln Lys 
    450                 455                 460


Thr Leu Gly Thr Met Ile Ala Gly Asp Thr Ser Gly Asp Tyr Arg Arg 
465                 470                 475                 480


Leu Leu Leu Ala Ile Val Gly Gln 
                485


<210>  784
<211>  2433
<212>  DNA
<213>  Homo sapiens

<400>  784
atttcacttg gaggaaagag agaaggaagg aagctgagga cttagcaggg tatcactgga     60

caggccatgg ctccacggtc ccggcgacga aggcacaaga aacctccctc atcagtggct    120

cccatcatca tggccccaac cacaattgtg acccctgtgc ctctgacccc ctcaaaacct    180

ggccctagca ttgacacact tggcttcttc tccttggatg ataatgttcc tggcctatcg    240

cagctgatcc ttcaaaagct gaacatgaaa agctatgaag aatataagtt ggtggtagat    300

gggggtaccc ccgtatcagg ctttggattt cgatgtcctc aagaaatgtt ccagaggatg    360

gaagacacat ttcgattctg tgctcactgt agagcactcc ctagtgggct ttcagactcc    420

aaggttctcc ggcactgtaa gaggtgcaga aatgtctatt actgtggtcc agagtgccag    480

aagtcagact ggcccgcaca caggagggtt tgtcaagagc ttcgtcttgt ggctgtggac    540

cgtctcatgg aatggcttct ggtcacaggt gattttgttc taccctcagg accttggcca    600

tggccacctg aagctgtaca ggactgggac tcctggtttt ctatgaaggg gttacaccta    660

gatgctacat tggatgctgt gctagttagt catgctgtga ccaccttatg ggccagtgta    720

ggacggccaa ggccagaccc ggatgtcctg cagggatctt tgaagcggct gctgacagat    780

gtcctgtcac ggcccttgac tctaggccta ggacttaggg ccttggggat agatgttagg    840

aggactgggg gaagcacagt gcatgtggtt ggtgcttccc atgtggagac atttcttact    900

cgcccagggg actatgatga gcttggttac atgtttcctg ggcaccttgg actccgtgtg    960

gtcatggtgg gtgtagatgt agctactggc ttttcacaga gcacctcaac ttcacccctg   1020

gaacctggca caattcagct tagtgcccac aggggcctct accatgactt ctgggaggag   1080

caagtagaga ccgggcagac acaccatcca gatttggtgg cggcattcca tccaggtttt   1140

cattcctccc cagacttgat ggaggcttgg ctgcccaccc tgctgctact tcgtgactat   1200

aagattccta cattgattac tgtttacagc catcaggagt tggtatcctc tttgcagatt   1260

ctggtggaac tggatacaca catcactgcc tttgggtcta atcctttcat gtccctcaaa   1320

cctgaacagg tctattccag tcccaacaag cagccagtat actgcagtgc atactatatc   1380

atgtttcttg gaagctcctg tcagctggat aataggcaat tagaagagaa agtggacggc   1440

gggatttaaa tagatcataa ctggacatct ggaaaacggg gagtttgtga tgaaattacc   1500

ctgctaatgc caggttcttg caaactttga aaaacattat attctaaacc tcatttactg   1560

tttgggtaaa aattctaagc tgaatgagag tttctgtata acataactgg tttctttctt   1620

tttttgagat ggagtcttgc tctgttgccc aggctggagt gcagcggcat gatctcgact   1680

cactgcagcc tccgcctcct gggttcaagt ggttctcctg cctcagcctc cctagtagct   1740

gggattacag gtgcacacca ccacacctgg ctaatttttg tatttttagc agacagggtt   1800

tcaccatgtt ggccaggctc gtatcaaacc cttgacccca ggtgatctgc ctgcctcagc   1860

ctcccaaagt tctgggatta caggcatgag ccaccatgcc cagccaatgt aactggtttc   1920

taagagttta gccacagtag cttctagaga taggaaatta gatttagtgg gtgggaagag   1980

gccctgatgc tggtctttcc agagcttata gttgctaaca cttttctttg taaagaagtt   2040

taccttttga ctggaaccag atggcactga gaaaaagaat gagaaccacc ttattcttct   2100

gaaaaagact ttcttctcat ccagtaattt gggctaaaaa atggaaagat gttgatgact   2160

tgaagtgatg caagaatgga caagtcaggg aagtcattgg gaacatggat gaggttgtaa   2220

gcattggtac agtgtcctgt ttcctgactt ttttgagaga aatgtctact tttcctgttt   2280

tctcttgggg acttttgacc ctagagtagc cctggtgtta tattttagat atcccaagct   2340

atatcagact ttacctgaat atactggagt tacttattat cccccattct ataccccaat   2400

aaactcagtt tggggcttct taaaaaaaaa aaa                                2433


<210>  785
<211>  460
<212>  PRT
<213>  Homo sapiens

<400>  785

Met Ala Pro Arg Ser Arg Arg Arg Arg His Lys Lys Pro Pro Ser Ser 
1               5                   10                  15


Val Ala Pro Ile Ile Met Ala Pro Thr Thr Ile Val Thr Pro Val Pro 
            20                  25                  30


Leu Thr Pro Ser Lys Pro Gly Pro Ser Ile Asp Thr Leu Gly Phe Phe 
        35                  40                  45


Ser Leu Asp Asp Asn Val Pro Gly Leu Ser Gln Leu Ile Leu Gln Lys 
    50                  55                  60


Leu Asn Met Lys Ser Tyr Glu Glu Tyr Lys Leu Val Val Asp Gly Gly 
65                  70                  75                  80


Thr Pro Val Ser Gly Phe Gly Phe Arg Cys Pro Gln Glu Met Phe Gln 
                85                  90                  95


Arg Met Glu Asp Thr Phe Arg Phe Cys Ala His Cys Arg Ala Leu Pro 
            100                 105                 110


Ser Gly Leu Ser Asp Ser Lys Val Leu Arg His Cys Lys Arg Cys Arg 
        115                 120                 125


Asn Val Tyr Tyr Cys Gly Pro Glu Cys Gln Lys Ser Asp Trp Pro Ala 
    130                 135                 140


His Arg Arg Val Cys Gln Glu Leu Arg Leu Val Ala Val Asp Arg Leu 
145                 150                 155                 160


Met Glu Trp Leu Leu Val Thr Gly Asp Phe Val Leu Pro Ser Gly Pro 
                165                 170                 175


Trp Pro Trp Pro Pro Glu Ala Val Gln Asp Trp Asp Ser Trp Phe Ser 
            180                 185                 190


Met Lys Gly Leu His Leu Asp Ala Thr Leu Asp Ala Val Leu Val Ser 
        195                 200                 205


His Ala Val Thr Thr Leu Trp Ala Ser Val Gly Arg Pro Arg Pro Asp 
    210                 215                 220


Pro Asp Val Leu Gln Gly Ser Leu Lys Arg Leu Leu Thr Asp Val Leu 
225                 230                 235                 240


Ser Arg Pro Leu Thr Leu Gly Leu Gly Leu Arg Ala Leu Gly Ile Asp 
                245                 250                 255


Val Arg Arg Thr Gly Gly Ser Thr Val His Val Val Gly Ala Ser His 
            260                 265                 270


Val Glu Thr Phe Leu Thr Arg Pro Gly Asp Tyr Asp Glu Leu Gly Tyr 
        275                 280                 285


Met Phe Pro Gly His Leu Gly Leu Arg Val Val Met Val Gly Val Asp 
    290                 295                 300


Val Ala Thr Gly Phe Ser Gln Ser Thr Ser Thr Ser Pro Leu Glu Pro 
305                 310                 315                 320


Gly Thr Ile Gln Leu Ser Ala His Arg Gly Leu Tyr His Asp Phe Trp 
                325                 330                 335


Glu Glu Gln Val Glu Thr Gly Gln Thr His His Pro Asp Leu Val Ala 
            340                 345                 350


Ala Phe His Pro Gly Phe His Ser Ser Pro Asp Leu Met Glu Ala Trp 
        355                 360                 365


Leu Pro Thr Leu Leu Leu Leu Arg Asp Tyr Lys Ile Pro Thr Leu Ile 
    370                 375                 380


Thr Val Tyr Ser His Gln Glu Leu Val Ser Ser Leu Gln Ile Leu Val 
385                 390                 395                 400


Glu Leu Asp Thr His Ile Thr Ala Phe Gly Ser Asn Pro Phe Met Ser 
                405                 410                 415


Leu Lys Pro Glu Gln Val Tyr Ser Ser Pro Asn Lys Gln Pro Val Tyr 
            420                 425                 430


Cys Ser Ala Tyr Tyr Ile Met Phe Leu Gly Ser Ser Cys Gln Leu Asp 
        435                 440                 445


Asn Arg Gln Leu Glu Glu Lys Val Asp Gly Gly Ile 
    450                 455                 460


<210>  786
<211>  3079
<212>  DNA
<213>  Homo sapiens

<400>  786
gggccctaca gagggtccgc catgttcccc ggcggcgccg ccgcttggct ctggtagccg     60

ccgcccccgc ccccaacccc gcccggccca gagcctagcc gagccccggg cccagcatgg    120

ccgccccgga gccggcccgg gctgcaccgc ccccaccccc gcccccgccg ccccctcccg    180

gggctgaccg cgtcgtcaaa gctgtccctt tccccccaac acatcgcttg acatctgaag    240

aagtatttga tttggatggg atacccaggg ttgatgttct gaagaaccac ttggtgaaag    300

aaggtcgagt agatgaagaa attgcgctta gaattatcaa tgagggtgct gccatccttc    360

ggagagagaa aaccatgata gaagtagaag ctccaatcac agtgtgtggt gacatccatg    420

gccaattttt tgatctgatg aaactttttg aagtaggagg atcacctgct aatacacgat    480

acctttttct tggcgattat gtggacagag gttattttag tatagagtgt gtcttatatt    540

tatgggttct gaagattcta tacccaagca cattatttct tctgagaggc aaccatgaat    600

gcagacacct tactgaatat tttaccttta agcaggaatg taaaattaag tattcggaaa    660

gagtctatga agcttgtatg gaagcttttg atagtttgcc tcttgctgca cttttaaacc    720

aacagtttct ttgtgttcat ggtggacttt caccagaaat acacacactg gatgatatta    780

ggagattaga tagattcaaa gagccacctg catttggacc aatgtgtgac ttgttatggt    840

ccgatccttc tgaagatttt ggaaatgaaa aatcacagga acattttagt cacaatacag    900

ttcgaggatg ttcttatttt tataactatc cagcagtgtg tgaatttttg caaaacaata    960

atttgttatc gattattaga gctcatgaag ctcaagatgc aggctataga atgtacagaa   1020

aaagtcaaac tacagggttc ccttcattaa taacaatttt ttcggcacct aattacttag   1080

atgtctacaa taataaagct gctgtattaa agtatgaaaa taatgtgatg aatattcgac   1140

agtttaactg ttctccacat ccttactggt tgcctaattt tatggatgtc ttcacgtggt   1200

ctttaccgtt tgttggagaa aaagtgacag aaatgttggt aaatgttctg agtatttgct   1260

ctgatgatga actaatgact gaaggtgaag accagtttga tggttcagct gcagcccgga   1320

aagaaatcat aagaaacaaa attcgagcaa ttggcaagat ggcaagagtc ttctctgttc   1380

tcagggagga gagtgaaagt gtgctgacac tcaagggcct gactcccaca gggatgttgc   1440

ctagtggagt gttagctgga ggacggcaga ccctgcaaag tgccacagtt gaggctattg   1500

aggctgaaaa agcaatacga ggattctctc caccacatag aatctgcagt tttgaagagg   1560

caaagggttt ggataggatc aatgagagaa tgccacctcg gaaagatgct gtacagcaag   1620

atggtttcaa ttctctgaac accgcacatg ccactgagaa ccacgggacg ggcaaccata   1680

ctgcccagtg acccactact tcccagggac tctcacatct cgggccccaa atggacagat   1740

cacccgagga gctggagggg tcggccaagc tgactgtaaa tttcacagtc tctctgaaga   1800

aaccattgtg cttctgagac cctagccccc ttcctggatg gaggcttgag ggccctggga   1860

catgtgctat ctgataagat tgggtcatcg ctgccaaggt ggagagcagt gagcaagggg   1920

cttggggcaa tttccagtgg agggcatcca cacctccatt ttatgcttgt ggttcacaca   1980

tttaagttta caaatcagat ttcttttccc cttcagtaga attagatttt gtttttcaat   2040

catgatttca aatgcaatcc taagagctaa tgtggacttt tctttttcca tgaaatgtct   2100

ttaaaggatg aattagcatg gtcttaaaat acatttctga ggttactagc tgtattttga   2160

attgtgagca aaatgccgag aaacccagtt ggcatttata caaaatgttg acctcaggtc   2220

tatagttctt aaatgtggct aattctgtaa catagtcttg gtatttttta attatgaatg   2280

catatcctat ttccaggcag gctctcttac ttgaacacaa atccaaaaac taatttagag   2340

tcttttttgc ccagatcttt taagacttac accccagaga tttaagaaga aaacctctaa   2400

atttcaaaat tatgaagaat tacagaatta ctcatttaag gtactttaaa agaagtttgt   2460

acattgtcaa agtaaatttt aattcaaatc atgtctgtaa aacttgacgt attttgtgta   2520

tgcatgtttt cattttgcaa atatttaata tatagaccta tgatgtacag gtacgacatg   2580

tataggttac ctagatgtta tgagaaattt tagtttattg tgagtactca agttgcttag   2640

agagccacca gggtgatttg ctgctggctt tctatcattt ttatgtttta atgcaaagga   2700

aattttaaaa tgttctggaa gtgtttttga ttaagcaatg cagcctagaa gcaatggttc   2760

tgttcaatca ttcagatgtt agtggaagca taaaagtcaa gactgcatgt tgaaaccttt   2820

cttttgatag ttactgaact gcttggttaa actaaatgga accatgtgct aatttttcac   2880

aattattgac ctgtattgat tgccactgta gtttggtatt tccctttact ttggtggcct   2940

gcttccctca tgccctggaa tacaactcag agctccaggc agcggaacca tctattgttt   3000

tgtttgccag aaagtgcacc ctgtatggtc tcctgtctaa gttggaaata ttatgcatgt   3060

gcaggactat tcgagtatt                                                3079


<210>  787
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  787

Met Ala Ala Pro Glu Pro Ala Arg Ala Ala Pro Pro Pro Pro Pro Pro 
1               5                   10                  15


Pro Pro Pro Pro Pro Gly Ala Asp Arg Val Val Lys Ala Val Pro Phe 
            20                  25                  30


Pro Pro Thr His Arg Leu Thr Ser Glu Glu Val Phe Asp Leu Asp Gly 
        35                  40                  45


Ile Pro Arg Val Asp Val Leu Lys Asn His Leu Val Lys Glu Gly Arg 
    50                  55                  60


Val Asp Glu Glu Ile Ala Leu Arg Ile Ile Asn Glu Gly Ala Ala Ile 
65                  70                  75                  80


Leu Arg Arg Glu Lys Thr Met Ile Glu Val Glu Ala Pro Ile Thr Val 
                85                  90                  95


Cys Gly Asp Ile His Gly Gln Phe Phe Asp Leu Met Lys Leu Phe Glu 
            100                 105                 110


Val Gly Gly Ser Pro Ala Asn Thr Arg Tyr Leu Phe Leu Gly Asp Tyr 
        115                 120                 125


Val Asp Arg Gly Tyr Phe Ser Ile Glu Cys Val Leu Tyr Leu Trp Val 
    130                 135                 140


Leu Lys Ile Leu Tyr Pro Ser Thr Leu Phe Leu Leu Arg Gly Asn His 
145                 150                 155                 160


Glu Cys Arg His Leu Thr Glu Tyr Phe Thr Phe Lys Gln Glu Cys Lys 
                165                 170                 175


Ile Lys Tyr Ser Glu Arg Val Tyr Glu Ala Cys Met Glu Ala Phe Asp 
            180                 185                 190


Ser Leu Pro Leu Ala Ala Leu Leu Asn Gln Gln Phe Leu Cys Val His 
        195                 200                 205


Gly Gly Leu Ser Pro Glu Ile His Thr Leu Asp Asp Ile Arg Arg Leu 
    210                 215                 220


Asp Arg Phe Lys Glu Pro Pro Ala Phe Gly Pro Met Cys Asp Leu Leu 
225                 230                 235                 240


Trp Ser Asp Pro Ser Glu Asp Phe Gly Asn Glu Lys Ser Gln Glu His 
                245                 250                 255


Phe Ser His Asn Thr Val Arg Gly Cys Ser Tyr Phe Tyr Asn Tyr Pro 
            260                 265                 270


Ala Val Cys Glu Phe Leu Gln Asn Asn Asn Leu Leu Ser Ile Ile Arg 
        275                 280                 285


Ala His Glu Ala Gln Asp Ala Gly Tyr Arg Met Tyr Arg Lys Ser Gln 
    290                 295                 300


Thr Thr Gly Phe Pro Ser Leu Ile Thr Ile Phe Ser Ala Pro Asn Tyr 
305                 310                 315                 320


Leu Asp Val Tyr Asn Asn Lys Ala Ala Val Leu Lys Tyr Glu Asn Asn 
                325                 330                 335


Val Met Asn Ile Arg Gln Phe Asn Cys Ser Pro His Pro Tyr Trp Leu 
            340                 345                 350


Pro Asn Phe Met Asp Val Phe Thr Trp Ser Leu Pro Phe Val Gly Glu 
        355                 360                 365


Lys Val Thr Glu Met Leu Val Asn Val Leu Ser Ile Cys Ser Asp Asp 
    370                 375                 380


Glu Leu Met Thr Glu Gly Glu Asp Gln Phe Asp Gly Ser Ala Ala Ala 
385                 390                 395                 400


Arg Lys Glu Ile Ile Arg Asn Lys Ile Arg Ala Ile Gly Lys Met Ala 
                405                 410                 415


Arg Val Phe Ser Val Leu Arg Glu Glu Ser Glu Ser Val Leu Thr Leu 
            420                 425                 430


Lys Gly Leu Thr Pro Thr Gly Met Leu Pro Ser Gly Val Leu Ala Gly 
        435                 440                 445


Gly Arg Gln Thr Leu Gln Ser Ala Thr Val Glu Ala Ile Glu Ala Glu 
    450                 455                 460


Lys Ala Ile Arg Gly Phe Ser Pro Pro His Arg Ile Cys Ser Phe Glu 
465                 470                 475                 480


Glu Ala Lys Gly Leu Asp Arg Ile Asn Glu Arg Met Pro Pro Arg Lys 
                485                 490                 495


Asp Ala Val Gln Gln Asp Gly Phe Asn Ser Leu Asn Thr Ala His Ala 
            500                 505                 510


Thr Glu Asn His Gly Thr Gly Asn His Thr Ala Gln 
        515                 520


<210>  788
<211>  6202
<212>  DNA
<213>  Homo sapiens

<400>  788
gctaaatgtg aacaataatg tcttggaaga gaaattattt ttcagggggt cgtggtagtg     60

tacaagggat gtttgcacct cgaagctcaa cctccatagc ccccagcaaa ggcctcagca    120

atgagccagg gcaaaacagc tgcttcctca acagtgccct gcaggttttg tggcacttgg    180

atatcttccg acgtagcttt aggcagctta caactcacaa gtgcatggga gattcctgca    240

tcttttgcgc tctcaaggga atctttaacc agtttcagtg tagtagtgaa aaagtgcttc    300

catctgacac tctccgcagt gctctggcaa agactttcca ggatgaacaa cgtttccagc    360

tgggaattat ggatgatgct gcagagtgct ttgaaaacct cctgatgaga attcacttcc    420

acattgctga tgaaaccaaa gaggatatat gtactgccca acactgcatt tcccatcaga    480

aatttgcaat gacattgttt gagcagtgtg tatgtactag ctgtggtgcc acttctgatc    540

cgctgccttt catccagatg gtacattata tctccaccac ttccctttgc aatcaggcta    600

tttgtatgct ggaaagacga gagaaacctt caccaagcat gtttggtgag ctgctgcaga    660

atgccagcac catgggggat ctgcggaact gtccaagcaa ctgtggagag aggatcagga    720

ttcgccgtgt gttgatgaat gctccacaga ttatcacgat tgggctggta tgggactcag    780

accactcaga cttagcagaa gatgttatcc acagcctggg aacctgcctt aagctgggtg    840

atctgttttt cagagtgacg gatgaccggg ccaagcaatc tgaactgtac ttagttggaa    900

tgatctgtta ctatggcaaa cattattcta cattcttttt tcaaacaaag attcgcaaat    960

ggatgtattt tgatgatgct catgtcaagg agattgggcc caaatggaag gatgtggtga   1020

ccaaatgcat caaggggcat tatcagcccc tgctgctgct ttatgcagat ccccagggta   1080

ccccagtttc cacccaggac ctgcctcccc aagctgagtt ccagtcatac agcaggacat   1140

gctacgacag tgaagattca gggagggagc cctccatctc aagtgacact cgaacagatt   1200

cctcaacgga gagctatccc tacaaacatt cccaccatga gtctgtggtc agtcacttct   1260

cttctgattc tcaggggaca gtcatctata atgtggaaaa tgattccatg tctcagagca   1320

gtcgggacac aggacacctg actgatagtg aatgtaatca gaaacacaca tccaagaaag   1380

ggtcactgat agagcgcaag aggagctctg gtcgggttag gaggaaaggc gatgagcccc   1440

aggcctcggg ataccacagt gaaggagaaa cactgaaaga gaagcaggct cctagaaatg   1500

cctccaaacc atccagcagc accaacaggc tgagagattt taaagagaca gtcagcaata   1560

tgatccataa cagaccatcc ctggcttctc agaccaatgt aggctctcac tgcaggggca   1620

gaggaggaga ccagcctgac aaaaaacctc ctaggaccct gcctttacac tctcgtgact   1680

gggaaataga gagtaccagc agtgagtcaa aatccagttc ttccagcaag tatcgtccca   1740

catggagacc caaacgagaa tctctgaata ttgacagtat ctttagtaag gacaaaagga   1800

agcactgtgg ctatacccag cttagcccct tttctgagga ttcagctaaa gaatttatac   1860

cagatgaacc aagcaagcca ccttcttacg acattaaatt tggtggacca agcccccagt   1920

acaagcgctg gggcccagca cggccaggct ctcacctttt agagcagcac ccccgactaa   1980

tccagcgaat ggaatctggc tatgaaagca gtgagaggaa cagcagcagc cctgtcagcc   2040

tggatgcagc cctgcctgag agctcaaatg tctacaggga tccaagtgct aagagatcag   2100

ctgggttggt tccttcctgg cgtcatatcc caaagtcgca cagcagtagc atcctggagg   2160

tagactccac agcatccatg ggtggctgga caaagagtca gcctttctct ggtgaggaga   2220

tatcttctaa aagtgaactg gatgaattgc aggaagaggt ggccaggagg gcgcaggaac   2280

aggaacttcg aagaaaacgg gagaaggagt tagaggcagc gaaagggttt aaccctcatc   2340

ctagccgctt catggacttg gatgaactgc agaatcaggg gaggagtgac ggctttgaga   2400

ggtccctgca agaggcagag tcagtgtttg aagagtcact acatctggaa cagaaaggag   2460

actgtgctgc agctttggct ctctgtaatg aagctatctc taaactaaga cttgccctgc   2520

atggtgccag ctgtagcacg cacagcagag ccctagtcga taagaagttg caaatcagta   2580

ttcgaaaagc acggagcctg caggatcgca tgcagcagca gcaatcacca cagcagccgt   2640

cgcagccctc agcctgcctc ccaacacagg cggggactct ctctcagcca acaagtgaac   2700

agcctatccc gctccaagta ttgttaagcc aagaggccca actggaatcc ggcatggata   2760

cagagtttgg ggccagttct ttcttccatt cacctgcttc ctgccatgag tcacactcat   2820

cactatctcc agagtcatct gccccacagc acagctcccc cagtagatct gccttgaagc   2880

ttctgacttc ggttgaagta gacaacattg aaccctctgc attccacagg caaggtttac   2940

ctaaagcacc agggtggact gagaagaatt ctcatcatag ttgggagcca ttggatgccc   3000

cagagggtaa gctgcaaggc tctaggtgtg acaacagcag ttgcagcaag ctccctccac   3060

aagaaggaag aggcattgct caagaacagc tgttccaaga aaagaaggat cctgctaacc   3120

cctccccggt gatgcctgga atagccacct ctgagagggg tgatgaacac agcctaggct   3180

gtagtccttc aaattcatca gctcagccca gccttcccct gtatagaacc tgccacccca   3240

taatgcctgt tgcttcttca tttgtgcttc actgtcctga tcctgtgcag aaaactaacc   3300

aatgcctcca aggccaaagc ctcaaaactt cattgacttt aaaagtggac agaggcagtg   3360

aggagaccta taggccagag tttcccagca caaaggggct tgtccgttct ctggctgagc   3420

agttccagag gatgcagggt gtctccatga gggatagtac aggtttcaag gatagaagtt   3480

tgtcaggtag tctaaggaag aactcttccc cttctgattc taagcctcct ttctcacagg   3540

gtcaagagaa aggccactgg ccatgggcaa agcaacaatc ctctctggag ggtggggata   3600

gaccactttc ctgggaagag tccactgaac attcttctct tgccttaaac tctgggctgc   3660

ctaatggtga aacttctagc ggaggacagc ccaggttggc agagccagac atataccaag   3720

agaagctgtc ccaagtgaga gatgttaggt ctaaggatct gggcagcagt actgacttgg   3780

ggacttcctt gcctttggat tcctgggtga atatcacaag gttctgtgat tctcagctta   3840

agcatggggc acctaggcca ggaatgaagt cctcccctca tgattcccat acgtgtgtaa   3900

cctatccaga gagaaatcac atccttttgc atccacattg gaaccaagac acagagcagg   3960

agacctcaga attggagtct ctgtatcagg ccagtcttca ggcttctcaa gctggctgtt   4020

ctggatgggg gcagcaggat accgcctggc acccacttag ccaaacaggc tctgcagatg   4080

gcatggggag gaggttgcac tcagcccatg atcctggtct ctcaaagact tcaacagcag   4140

aaatggagca tggtctccat gaagccagaa cagtgcgtac ttctcaggct acaccttgcc   4200

gaggcctcag cagggagtgt ggggaggatg agcagtacag tgcagagaat ttacgtcgca   4260

tctcacgcag tctcagtggc accgttgtct cagagaggga ggaagctccg gtttcttccc   4320

acagttttga ttcatcaaac gtgaggaagc ctttggaaac cgggcaccgt tgttccagct   4380

cctcttccct ccctgtcatc catgaccctt ctgtgtttct cctcggtccc caactctacc   4440

ttccccaacc acagttcctg tccccagatg tcctgatgcc caccatggca ggggagccca   4500

atagactccc aggaacttca aggagtgtcc agcagtttct ggctatgtgt gacaggggtg   4560

aaacttccca aggggccaag tacacaggaa ggactttgaa ctaccagagc ctcccccatc   4620

gctccagaac agacaactcc tgggcaccct ggtcagagac caaccagcat attgggacca   4680

gattcctgac tactccaggg tgcaatcctc aactaaccta cactgccaca ctaccagaaa   4740

gaagcaaggg ccttcaggtt cctcacactc agtcctggag tgatcttttc cattcaccct   4800

cccaccctcc cattgttcat cctgtgtacc caccatctag cagtcttcat gtacccctga   4860

ggtcagcttg gaattcagat cctgttccag ggtcccgaac ccctggtcct cgaagagtag   4920

atatgccccc agatgatgac tggaggcaaa gcagttatgc ctcccactct ggacacagga   4980

gaacagtggg agaggggttt ctgtttgttc tatcagatgc tcccagaaga gagcagatca   5040

gggctagagt cctgcagcac agtcaatggt aaaggttatt cctttccttt cctggagcta   5100

cacctttctt tgtaaaactg tactgtgggc cgggcgcggt ggctcacacc tgtaatccca   5160

gcactttggg aggctgaggc gggtggatca cgaggtcagg agattgagac catcctggcc   5220

aacatggtga aaccccgtct ctaccaaaat acaaaaaatt agccaggcgt gacggtgcgt   5280

gcctgtagtc ccaactactc ggaaggctga ggcaggagaa ttgcttgaac ccgggaggca   5340

gaggttgcag tgagccgaga tcgcaccact gcactccagc ttggcaatag agtgagactc   5400

catctcaaaa aacaaaacaa aacaacaaca aaataaacta ctgtggcagc gttggtaccc   5460

tgcatcactg ccatggttgt gctattctca tctcaacata gaattggtgg gttctcctaa   5520

gggtgtcagg aacctctaaa aagatgtgat tctttgggag gggatatttg aaattccaac   5580

ttccattccc cctagcaaaa ggaagcagct gctgtttaag ggttttatct gagccacttt   5640

aaagatgaat ccatggtatt actctggata ctagccattc cttaggattt taaggtcaca   5700

ttttattcct ggatgcttta tgtccccacc tccacctgag ccctcatcct ctgttcccta   5760

ctatactccc aacttctact ctttgtttta tccacctatc cctattacct gaccctttgt   5820

cttccctgtc tcccatcctt ggggggacat gtagccctgt ggtcatggtt ctgatgacat   5880

catcagggca gcccccctgc ccaggtatta tggcctgtca gcattccctg tgccctccaa   5940

accttaggcc tagaatgcgg agctgccaac ataacattca cccttttgaa cagatggagt   6000

caggcacact aacacagcct tctgtcctca ataacacagc cattattgcc acttgctcag   6060

tcgtcaatgt aaaccctcag agtcagctga actattttag gccaaacata ctgtttttgt   6120

aaagtatttt tcattaataa atctataaga cagttctatt taaaaaaaaa aaaaaaaaaa   6180

aaaaaaaaaa aaaaaaaaaa aa                                            6202


<210>  789
<211>  1684
<212>  PRT
<213>  Homo sapiens

<400>  789

Met Ser Trp Lys Arg Asn Tyr Phe Ser Gly Gly Arg Gly Ser Val Gln 
1               5                   10                  15


Gly Met Phe Ala Pro Arg Ser Ser Thr Ser Ile Ala Pro Ser Lys Gly 
            20                  25                  30


Leu Ser Asn Glu Pro Gly Gln Asn Ser Cys Phe Leu Asn Ser Ala Leu 
        35                  40                  45


Gln Val Leu Trp His Leu Asp Ile Phe Arg Arg Ser Phe Arg Gln Leu 
    50                  55                  60


Thr Thr His Lys Cys Met Gly Asp Ser Cys Ile Phe Cys Ala Leu Lys 
65                  70                  75                  80


Gly Ile Phe Asn Gln Phe Gln Cys Ser Ser Glu Lys Val Leu Pro Ser 
                85                  90                  95


Asp Thr Leu Arg Ser Ala Leu Ala Lys Thr Phe Gln Asp Glu Gln Arg 
            100                 105                 110


Phe Gln Leu Gly Ile Met Asp Asp Ala Ala Glu Cys Phe Glu Asn Leu 
        115                 120                 125


Leu Met Arg Ile His Phe His Ile Ala Asp Glu Thr Lys Glu Asp Ile 
    130                 135                 140


Cys Thr Ala Gln His Cys Ile Ser His Gln Lys Phe Ala Met Thr Leu 
145                 150                 155                 160


Phe Glu Gln Cys Val Cys Thr Ser Cys Gly Ala Thr Ser Asp Pro Leu 
                165                 170                 175


Pro Phe Ile Gln Met Val His Tyr Ile Ser Thr Thr Ser Leu Cys Asn 
            180                 185                 190


Gln Ala Ile Cys Met Leu Glu Arg Arg Glu Lys Pro Ser Pro Ser Met 
        195                 200                 205


Phe Gly Glu Leu Leu Gln Asn Ala Ser Thr Met Gly Asp Leu Arg Asn 
    210                 215                 220


Cys Pro Ser Asn Cys Gly Glu Arg Ile Arg Ile Arg Arg Val Leu Met 
225                 230                 235                 240


Asn Ala Pro Gln Ile Ile Thr Ile Gly Leu Val Trp Asp Ser Asp His 
                245                 250                 255


Ser Asp Leu Ala Glu Asp Val Ile His Ser Leu Gly Thr Cys Leu Lys 
            260                 265                 270


Leu Gly Asp Leu Phe Phe Arg Val Thr Asp Asp Arg Ala Lys Gln Ser 
        275                 280                 285


Glu Leu Tyr Leu Val Gly Met Ile Cys Tyr Tyr Gly Lys His Tyr Ser 
    290                 295                 300


Thr Phe Phe Phe Gln Thr Lys Ile Arg Lys Trp Met Tyr Phe Asp Asp 
305                 310                 315                 320


Ala His Val Lys Glu Ile Gly Pro Lys Trp Lys Asp Val Val Thr Lys 
                325                 330                 335


Cys Ile Lys Gly His Tyr Gln Pro Leu Leu Leu Leu Tyr Ala Asp Pro 
            340                 345                 350


Gln Gly Thr Pro Val Ser Thr Gln Asp Leu Pro Pro Gln Ala Glu Phe 
        355                 360                 365


Gln Ser Tyr Ser Arg Thr Cys Tyr Asp Ser Glu Asp Ser Gly Arg Glu 
    370                 375                 380


Pro Ser Ile Ser Ser Asp Thr Arg Thr Asp Ser Ser Thr Glu Ser Tyr 
385                 390                 395                 400


Pro Tyr Lys His Ser His His Glu Ser Val Val Ser His Phe Ser Ser 
                405                 410                 415


Asp Ser Gln Gly Thr Val Ile Tyr Asn Val Glu Asn Asp Ser Met Ser 
            420                 425                 430


Gln Ser Ser Arg Asp Thr Gly His Leu Thr Asp Ser Glu Cys Asn Gln 
        435                 440                 445


Lys His Thr Ser Lys Lys Gly Ser Leu Ile Glu Arg Lys Arg Ser Ser 
    450                 455                 460


Gly Arg Val Arg Arg Lys Gly Asp Glu Pro Gln Ala Ser Gly Tyr His 
465                 470                 475                 480


Ser Glu Gly Glu Thr Leu Lys Glu Lys Gln Ala Pro Arg Asn Ala Ser 
                485                 490                 495


Lys Pro Ser Ser Ser Thr Asn Arg Leu Arg Asp Phe Lys Glu Thr Val 
            500                 505                 510


Ser Asn Met Ile His Asn Arg Pro Ser Leu Ala Ser Gln Thr Asn Val 
        515                 520                 525


Gly Ser His Cys Arg Gly Arg Gly Gly Asp Gln Pro Asp Lys Lys Pro 
    530                 535                 540


Pro Arg Thr Leu Pro Leu His Ser Arg Asp Trp Glu Ile Glu Ser Thr 
545                 550                 555                 560


Ser Ser Glu Ser Lys Ser Ser Ser Ser Ser Lys Tyr Arg Pro Thr Trp 
                565                 570                 575


Arg Pro Lys Arg Glu Ser Leu Asn Ile Asp Ser Ile Phe Ser Lys Asp 
            580                 585                 590


Lys Arg Lys His Cys Gly Tyr Thr Gln Leu Ser Pro Phe Ser Glu Asp 
        595                 600                 605


Ser Ala Lys Glu Phe Ile Pro Asp Glu Pro Ser Lys Pro Pro Ser Tyr 
    610                 615                 620


Asp Ile Lys Phe Gly Gly Pro Ser Pro Gln Tyr Lys Arg Trp Gly Pro 
625                 630                 635                 640


Ala Arg Pro Gly Ser His Leu Leu Glu Gln His Pro Arg Leu Ile Gln 
                645                 650                 655


Arg Met Glu Ser Gly Tyr Glu Ser Ser Glu Arg Asn Ser Ser Ser Pro 
            660                 665                 670


Val Ser Leu Asp Ala Ala Leu Pro Glu Ser Ser Asn Val Tyr Arg Asp 
        675                 680                 685


Pro Ser Ala Lys Arg Ser Ala Gly Leu Val Pro Ser Trp Arg His Ile 
    690                 695                 700


Pro Lys Ser His Ser Ser Ser Ile Leu Glu Val Asp Ser Thr Ala Ser 
705                 710                 715                 720


Met Gly Gly Trp Thr Lys Ser Gln Pro Phe Ser Gly Glu Glu Ile Ser 
                725                 730                 735


Ser Lys Ser Glu Leu Asp Glu Leu Gln Glu Glu Val Ala Arg Arg Ala 
            740                 745                 750


Gln Glu Gln Glu Leu Arg Arg Lys Arg Glu Lys Glu Leu Glu Ala Ala 
        755                 760                 765


Lys Gly Phe Asn Pro His Pro Ser Arg Phe Met Asp Leu Asp Glu Leu 
    770                 775                 780


Gln Asn Gln Gly Arg Ser Asp Gly Phe Glu Arg Ser Leu Gln Glu Ala 
785                 790                 795                 800


Glu Ser Val Phe Glu Glu Ser Leu His Leu Glu Gln Lys Gly Asp Cys 
                805                 810                 815


Ala Ala Ala Leu Ala Leu Cys Asn Glu Ala Ile Ser Lys Leu Arg Leu 
            820                 825                 830


Ala Leu His Gly Ala Ser Cys Ser Thr His Ser Arg Ala Leu Val Asp 
        835                 840                 845


Lys Lys Leu Gln Ile Ser Ile Arg Lys Ala Arg Ser Leu Gln Asp Arg 
    850                 855                 860


Met Gln Gln Gln Gln Ser Pro Gln Gln Pro Ser Gln Pro Ser Ala Cys 
865                 870                 875                 880


Leu Pro Thr Gln Ala Gly Thr Leu Ser Gln Pro Thr Ser Glu Gln Pro 
                885                 890                 895


Ile Pro Leu Gln Val Leu Leu Ser Gln Glu Ala Gln Leu Glu Ser Gly 
            900                 905                 910


Met Asp Thr Glu Phe Gly Ala Ser Ser Phe Phe His Ser Pro Ala Ser 
        915                 920                 925


Cys His Glu Ser His Ser Ser Leu Ser Pro Glu Ser Ser Ala Pro Gln 
    930                 935                 940


His Ser Ser Pro Ser Arg Ser Ala Leu Lys Leu Leu Thr Ser Val Glu 
945                 950                 955                 960


Val Asp Asn Ile Glu Pro Ser Ala Phe His Arg Gln Gly Leu Pro Lys 
                965                 970                 975


Ala Pro Gly Trp Thr Glu Lys Asn Ser His His Ser Trp Glu Pro Leu 
            980                 985                 990


Asp Ala Pro Glu Gly Lys Leu Gln Gly Ser Arg Cys Asp Asn Ser Ser 
        995                 1000                1005


Cys Ser Lys Leu Pro Pro Gln Glu Gly Arg Gly Ile Ala Gln Glu Gln 
    1010                1015                1020


Leu Phe Gln Glu Lys Lys Asp Pro Ala Asn Pro Ser Pro Val Met Pro 
1025                1030                1035                1040


Gly Ile Ala Thr Ser Glu Arg Gly Asp Glu His Ser Leu Gly Cys Ser 
                1045                1050                1055


Pro Ser Asn Ser Ser Ala Gln Pro Ser Leu Pro Leu Tyr Arg Thr Cys 
            1060                1065                1070


His Pro Ile Met Pro Val Ala Ser Ser Phe Val Leu His Cys Pro Asp 
        1075                1080                1085


Pro Val Gln Lys Thr Asn Gln Cys Leu Gln Gly Gln Ser Leu Lys Thr 
    1090                1095                1100


Ser Leu Thr Leu Lys Val Asp Arg Gly Ser Glu Glu Thr Tyr Arg Pro 
1105                1110                1115                1120


Glu Phe Pro Ser Thr Lys Gly Leu Val Arg Ser Leu Ala Glu Gln Phe 
                1125                1130                1135


Gln Arg Met Gln Gly Val Ser Met Arg Asp Ser Thr Gly Phe Lys Asp 
            1140                1145                1150


Arg Ser Leu Ser Gly Ser Leu Arg Lys Asn Ser Ser Pro Ser Asp Ser 
        1155                1160                1165


Lys Pro Pro Phe Ser Gln Gly Gln Glu Lys Gly His Trp Pro Trp Ala 
    1170                1175                1180


Lys Gln Gln Ser Ser Leu Glu Gly Gly Asp Arg Pro Leu Ser Trp Glu 
1185                1190                1195                1200


Glu Ser Thr Glu His Ser Ser Leu Ala Leu Asn Ser Gly Leu Pro Asn 
                1205                1210                1215


Gly Glu Thr Ser Ser Gly Gly Gln Pro Arg Leu Ala Glu Pro Asp Ile 
            1220                1225                1230


Tyr Gln Glu Lys Leu Ser Gln Val Arg Asp Val Arg Ser Lys Asp Leu 
        1235                1240                1245


Gly Ser Ser Thr Asp Leu Gly Thr Ser Leu Pro Leu Asp Ser Trp Val 
    1250                1255                1260


Asn Ile Thr Arg Phe Cys Asp Ser Gln Leu Lys His Gly Ala Pro Arg 
1265                1270                1275                1280


Pro Gly Met Lys Ser Ser Pro His Asp Ser His Thr Cys Val Thr Tyr 
                1285                1290                1295


Pro Glu Arg Asn His Ile Leu Leu His Pro His Trp Asn Gln Asp Thr 
            1300                1305                1310


Glu Gln Glu Thr Ser Glu Leu Glu Ser Leu Tyr Gln Ala Ser Leu Gln 
        1315                1320                1325


Ala Ser Gln Ala Gly Cys Ser Gly Trp Gly Gln Gln Asp Thr Ala Trp 
    1330                1335                1340


His Pro Leu Ser Gln Thr Gly Ser Ala Asp Gly Met Gly Arg Arg Leu 
1345                1350                1355                1360


His Ser Ala His Asp Pro Gly Leu Ser Lys Thr Ser Thr Ala Glu Met 
                1365                1370                1375


Glu His Gly Leu His Glu Ala Arg Thr Val Arg Thr Ser Gln Ala Thr 
            1380                1385                1390


Pro Cys Arg Gly Leu Ser Arg Glu Cys Gly Glu Asp Glu Gln Tyr Ser 
        1395                1400                1405


Ala Glu Asn Leu Arg Arg Ile Ser Arg Ser Leu Ser Gly Thr Val Val 
    1410                1415                1420


Ser Glu Arg Glu Glu Ala Pro Val Ser Ser His Ser Phe Asp Ser Ser 
1425                1430                1435                1440


Asn Val Arg Lys Pro Leu Glu Thr Gly His Arg Cys Ser Ser Ser Ser 
                1445                1450                1455


Ser Leu Pro Val Ile His Asp Pro Ser Val Phe Leu Leu Gly Pro Gln 
            1460                1465                1470


Leu Tyr Leu Pro Gln Pro Gln Phe Leu Ser Pro Asp Val Leu Met Pro 
        1475                1480                1485


Thr Met Ala Gly Glu Pro Asn Arg Leu Pro Gly Thr Ser Arg Ser Val 
    1490                1495                1500


Gln Gln Phe Leu Ala Met Cys Asp Arg Gly Glu Thr Ser Gln Gly Ala 
1505                1510                1515                1520


Lys Tyr Thr Gly Arg Thr Leu Asn Tyr Gln Ser Leu Pro His Arg Ser 
                1525                1530                1535


Arg Thr Asp Asn Ser Trp Ala Pro Trp Ser Glu Thr Asn Gln His Ile 
            1540                1545                1550


Gly Thr Arg Phe Leu Thr Thr Pro Gly Cys Asn Pro Gln Leu Thr Tyr 
        1555                1560                1565


Thr Ala Thr Leu Pro Glu Arg Ser Lys Gly Leu Gln Val Pro His Thr 
    1570                1575                1580


Gln Ser Trp Ser Asp Leu Phe His Ser Pro Ser His Pro Pro Ile Val 
1585                1590                1595                1600


His Pro Val Tyr Pro Pro Ser Ser Ser Leu His Val Pro Leu Arg Ser 
                1605                1610                1615


Ala Trp Asn Ser Asp Pro Val Pro Gly Ser Arg Thr Pro Gly Pro Arg 
            1620                1625                1630


Arg Val Asp Met Pro Pro Asp Asp Asp Trp Arg Gln Ser Ser Tyr Ala 
        1635                1640                1645


Ser His Ser Gly His Arg Arg Thr Val Gly Glu Gly Phe Leu Phe Val 
    1650                1655                1660


Leu Ser Asp Ala Pro Arg Arg Glu Gln Ile Arg Ala Arg Val Leu Gln 
1665                1670                1675                1680


His Ser Gln Trp 



<210>  790
<211>  896
<212>  DNA
<213>  Homo sapiens

<400>  790
gttgaagaaa gaggatctgg ctgaaagacc cgcaactttc acttgttgag aacctttagc     60

cagcgccggc gtgcatgtgt tttagtttta ttctttttcc cttgccccca aagccgtgga    120

gtacctgctg ttgctctcat gcctcttgcc aacagtggca tctgctcagt gtagccatca    180

agaatttgaa tgtcaatatc tttgccttga aatgaatgga aaagtatttg tcactcagcg    240

gcaatcattc ttcaaataaa aggtcactgg aaggactgag cgcattcagg agcctggagg    300

aactcatctt ggacaacaat cagctggggg acgaccttgt gttgccaggg ttacccagac    360

tgcatacctt aaccctcaac aagaaccgaa tcactgattt ggagaacctg ctggatcact    420

tggcagaagt gacaccagct ctggagtacc tcagtctgct gggcaacgtg gcctgtccca    480

acgagctggt cagcttggaa aaggatgagg aagactacaa gagatacaga tgctttgttc    540

tgtacaagct gcccaacttg aaatttctgg atgcccagaa agtaaccaga caagaacgag    600

aggaggcgtt ggtcagagga gtcttcatga aggtggtgaa gcccaaggct tctagtgagg    660

acgttgccag ctccccggag cgccactaca cgcccttgcc ttctgcttcc agggaactca    720

ccagtcacca aggtgtcctg gggaagtgtc gctacgttta ctatgggaaa aactcagagg    780

gcaacaggtt tatccgagat gaccagctct gaagccaact tctgtatacc ttcacccatt    840

tcatgaaaat aaaatcaaaa gggaaatcaa aaataaagaa aacgctaaag aaaaaa        896


<210>  791
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  791

Met Glu Lys Tyr Leu Ser Leu Ser Gly Asn His Ser Ser Asn Lys Arg 
1               5                   10                  15


Ser Leu Glu Gly Leu Ser Ala Phe Arg Ser Leu Glu Glu Leu Ile Leu 
            20                  25                  30


Asp Asn Asn Gln Leu Gly Asp Asp Leu Val Leu Pro Gly Leu Pro Arg 
        35                  40                  45


Leu His Thr Leu Thr Leu Asn Lys Asn Arg Ile Thr Asp Leu Glu Asn 
    50                  55                  60


Leu Leu Asp His Leu Ala Glu Val Thr Pro Ala Leu Glu Tyr Leu Ser 
65                  70                  75                  80


Leu Leu Gly Asn Val Ala Cys Pro Asn Glu Leu Val Ser Leu Glu Lys 
                85                  90                  95


Asp Glu Glu Asp Tyr Lys Arg Tyr Arg Cys Phe Val Leu Tyr Lys Leu 
            100                 105                 110


Pro Asn Leu Lys Phe Leu Asp Ala Gln Lys Val Thr Arg Gln Glu Arg 
        115                 120                 125


Glu Glu Ala Leu Val Arg Gly Val Phe Met Lys Val Val Lys Pro Lys 
    130                 135                 140


Ala Ser Ser Glu Asp Val Ala Ser Ser Pro Glu Arg His Tyr Thr Pro 
145                 150                 155                 160


Leu Pro Ser Ala Ser Arg Glu Leu Thr Ser His Gln Gly Val Leu Gly 
                165                 170                 175


Lys Cys Arg Tyr Val Tyr Tyr Gly Lys Asn Ser Glu Gly Asn Arg Phe 
            180                 185                 190


Ile Arg Asp Asp Gln Leu 
        195


<210>  792
<211>  105
<212>  DNA
<213>  Homo sapiens

<400>  792
atggcaggaa gtaaaactaa tgagagtgtc ctggggaagt gtcgctacgt ttactatggg     60

aaaaactcag agggcaacag gtttatccga gatgaccagc tctga                    105


<210>  793
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  793

Met Ala Gly Ser Lys Thr Asn Glu Ser Val Leu Gly Lys Cys Arg Tyr 
1               5                   10                  15


Val Tyr Tyr Gly Lys Asn Ser Glu Gly Asn Arg Phe Ile Arg Asp Asp 
            20                  25                  30


Gln Leu 



<210>  794
<211>  2556
<212>  DNA
<213>  Homo sapiens

<400>  794
aacttgctct aacttcctcg gccgagccgg gccgcgccgc cgctgccgcc gccgcgcgcg     60

gattctgctt ctcagaagat gcactattat agatactcta acgccaaggt cagctgctgg    120

tacaagtacc tccttttcag ctacaacatc atcttctggt tggctggagt tgtcttcctt    180

ggagtcgggc tgtgggcatg gagcgaaaag ggtgtgctgt ccgacctcac caaagtgacc    240

cggatgcatg gaatcgaccc tgtggtgctg gtcctgatgg tgggcgtggt gatgttcacc    300

ctggggttcg ccggctgcgt gggggctctg cgggagaata tctgcttgct caactttttc    360

tgtggcacca tcgtgctcat cttcttcctg gagctggctg tggccgtgct ggccttcctg    420

ttccaggact gggtgaggga ccggttccgg gagttcttcg agagcaacat caagtcctac    480

cgggacgata tcgatctgca aaacgtcatc gactcccttc agaaagctaa ccagtgctgt    540

ggcgcatatg gccctgaaga ctgggacctc aacgtctact tcaattgcag cggtgccagc    600

tacagccgag agaagtgcgg ggtccccttc tcctgctgcg tgccagatcc tgcgcaaaaa    660

gttgtgaaca cacagtgtgg atatgatgtc aggattcagc tgaagagcaa gtgggatgag    720

tccatcttca cgaaaggctg catccaggcg ctggaaagct ggctcccgcg gaacatttac    780

attgtggctg gcgtcttcat cgccatctcg ctgttgcaga tatttggcat cttcctggca    840

aggacgctga tctcagacat cgaggcagtg aaggccggcc gtcacttctg aggagcagag    900

ttgagggagc cgagctgagc cacgctggga ggccagagcc tttctctgcc atcagcccta    960

cgtccagagg gagaggagcc gacaccccca gagccagtgc cccatcttaa gcatcagcgt   1020

gacgtgacct ctctgtttct gcttgctggt gctgaagacc aagggtcccc cttgttacct   1080

gcccaaactt gtgactgcat ccctctggag tctacccaga gacagagaat gtgtctttat   1140

gtgggagtgg tgactctgaa agacagagag ggctcctgtg gctgccagga gggcttgact   1200

cagaccccct gcagctcaag catgtctgca ggacaccctg gtcccctctc cactggcatc   1260

cagacatctg ctttgggtca tccacatctg tgggtgggcc gtgggtagag ggacccacag   1320

gcgtggaccg ggcatctccc tccatcaagc aaagcagcat gggggcctgc ccgtaacggg   1380

aggcggacgt ggccccgctg ggcctctgag tgccagcgca gtctgctggg acatgcacat   1440

atcaggggtt gtttgcagga tcctcagcca tgttcaagtg aagtaagcct gagccagtgc   1500

gtggactggt gccacgggag tgccttgtcc actgtccccc tgtgtccacc agctattctc   1560

ctggcgccgg aactgcctct ggtcttgata gcattaagcc ctgatggcgc cggtggcgcg   1620

gtgggcatgg ttcttcactg agagccggct ctccttttct taaagtgtgt aaatagttta   1680

tttatagggg taagaatgtt ctcacaccat ttcacttcct cttcctctcc tccagcattc   1740

tcctctgagc agccttagat agtgtccatg gctggagccg accctttgag tccccttgag   1800

tgtcttaaga accagcccac aacagcctct ctttctcctc cacatactgc agcctccctc   1860

catgcatccc acatacaagc actcccccac tccccagcgt ggcctcactg tcttctggtc   1920

ttggtgctac tgaaattgtc acccagaatt tgaatcctga ccctccccac tgcaagccca   1980

gggagcccca gcccaagatg gccagcctga aactgttggc cagggctcct cttgtggcca   2040

tgtacccagg gctggctggc ctgccatttg cctctccccg gagacagccg ttcttctgca   2100

accacacccc gtgcctagcc acaaccccag gctgcagctg ctcagaagct ccaggcattt   2160

tgtttctggt gaccgcccct aatgggatat cggtgatcac tggtccaccc ttcctgtcag   2220

ggcttttctg gggctgctct tggaaatgaa gtcttaagta ctgaataact cccctgggga   2280

tagctggggc atttgtctag ctgggctacc ttctaacact ttgccatagc tcagaccact   2340

tctcatcgtt cagggatgga ctgcaacctt aatttacttg ccggagtgta cattctagtg   2400

tggtgtatac tggtggctgt tgatgacgat tttttttttt tttttacaca attctctgta   2460

gactaggaga agaatgcttg tgtttttcgg aagtgtgatg cttctctttg actgccaaac   2520

tcttttatgg aatatatctt tatattaaaa aaaaaa                             2556


<210>  795
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  795

Met His Tyr Tyr Arg Tyr Ser Asn Ala Lys Val Ser Cys Trp Tyr Lys 
1               5                   10                  15


Tyr Leu Leu Phe Ser Tyr Asn Ile Ile Phe Trp Leu Ala Gly Val Val 
            20                  25                  30


Phe Leu Gly Val Gly Leu Trp Ala Trp Ser Glu Lys Gly Val Leu Ser 
        35                  40                  45


Asp Leu Thr Lys Val Thr Arg Met His Gly Ile Asp Pro Val Val Leu 
    50                  55                  60


Val Leu Met Val Gly Val Val Met Phe Thr Leu Gly Phe Ala Gly Cys 
65                  70                  75                  80


Val Gly Ala Leu Arg Glu Asn Ile Cys Leu Leu Asn Phe Phe Cys Gly 
                85                  90                  95


Thr Ile Val Leu Ile Phe Phe Leu Glu Leu Ala Val Ala Val Leu Ala 
            100                 105                 110


Phe Leu Phe Gln Asp Trp Val Arg Asp Arg Phe Arg Glu Phe Phe Glu 
        115                 120                 125


Ser Asn Ile Lys Ser Tyr Arg Asp Asp Ile Asp Leu Gln Asn Val Ile 
    130                 135                 140


Asp Ser Leu Gln Lys Ala Asn Gln Cys Cys Gly Ala Tyr Gly Pro Glu 
145                 150                 155                 160


Asp Trp Asp Leu Asn Val Tyr Phe Asn Cys Ser Gly Ala Ser Tyr Ser 
                165                 170                 175


Arg Glu Lys Cys Gly Val Pro Phe Ser Cys Cys Val Pro Asp Pro Ala 
            180                 185                 190


Gln Lys Val Val Asn Thr Gln Cys Gly Tyr Asp Val Arg Ile Gln Leu 
        195                 200                 205


Lys Ser Lys Trp Asp Glu Ser Ile Phe Thr Lys Gly Cys Ile Gln Ala 
    210                 215                 220


Leu Glu Ser Trp Leu Pro Arg Asn Ile Tyr Ile Val Ala Gly Val Phe 
225                 230                 235                 240


Ile Ala Ile Ser Leu Leu Gln Ile Phe Gly Ile Phe Leu Ala Arg Thr 
                245                 250                 255


Leu Ile Ser Asp Ile Glu Ala Val Lys Ala Gly Arg His Phe 
            260                 265                 270


<210>  796
<211>  598
<212>  DNA
<213>  Homo sapiens

<400>  796
gaccccagga gcaggggtcg cgccgaagag cagagtccgc ggctggaaac caggcagggg     60

agccacggag tagtcacaca ggttttctgc cgcctttcaa ctggtcttat tttgctttca    120

tttttcacca gcccatgtgg ggtgtttaat gttgcacgcg aacgcagttt cttccgggcc    180

cggaaggccc acgcacgcaa caatgttgtg caagtgactg gaaaccacct gagtgtccct    240

ccatgggggt gggttgccca gcatggacct ctactcctgt cacaatgaag tcgactgttt    300

cgtcgaggga agtggccacc gttgataaaa tgaaaagacg ccatgcagaa tactgtgcac    360

aggaggaaag gtctgcgtgc cctaagagag agctgctggc gtgcagagag aagcagagat    420

gccgacgacg gggaggaaac acactggcgg tggtgaggct ccttccagca gccacagccc    480

tggttcctct cagtctgtga ccctcccaca tccttcccat ctatgagagc ctgtaaactc    540

cttttgctta accttgtttt agttaaggtt ttaaacagtt gccaccagtg tgccctaa      598


<210>  797
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  797

Met Lys Ser Thr Val Ser Ser Arg Glu Val Ala Thr Val Asp Lys Met 
1               5                   10                  15


Lys Arg Arg His Ala Glu Tyr Cys Ala Gln Glu Glu Arg Ser Ala Cys 
            20                  25                  30


Pro Lys Arg Glu Leu Leu Ala Cys Arg Glu Lys Gln Arg Cys Arg Arg 
        35                  40                  45


Arg Gly Gly Asn Thr Leu Ala Val Val Arg Leu Leu Pro Ala Ala Thr 
    50                  55                  60


Ala Leu Val Pro Leu Ser Leu 
65                  70


<210>  798
<211>  5572
<212>  DNA
<213>  Homo sapiens

<400>  798
cctcccctcg cccggcgcgg tcccgtccgc ctctcgctcg cctcccgcct cccctcggtc     60

ttccgaggcg cccgggctcc cggcgcggcg gcggaggggg cgggcaggcc ggcgggcggt    120

gatgtggcgg gactctttat gcgctgcggc aggatacgcg ctcggcgctg ggacgcgact    180

gcgctcagtt ctctcctctc ggaagctgca gccatgatgg aagtttgaga gttgagccgc    240

tgtgaggcga ggccgggctc aggcgaggga gatgagagac ggcggcggcc gcggcccgga    300

gcccctctca gcgcctgtga gcagccgcgg gggcagcgcc ctcggggagc cggccggcct    360

gcggcggcgg cagcggcggc gtttctcgcc tcctcttcgt cttttctaac cgtgcagcct    420

cttcctcggc ttctcctgaa agggaaggtg gaagccgtgg gctcgggcgg gagccggctg    480

aggcgcggcg gcggcggcgg cacctcccgc tcctggagcg ggggggagaa gcggcggcgg    540

cggcggccgc ggcggctgca gctccaggga gggggtctga gtcgcctgtc accatttcca    600

gggctgggaa cgccggagag ttggtctctc cccttctact gcctccaaca cggcggcggc    660

ggcggcggca catccaggga cccgggccgg ttttaaacct cccgtccgcc gccgccgcac    720

cccccgtggc ccgggctccg gaggccgccg gcggaggcag ccgttcggag gattattcgt    780

cttctcccca ttccgctgcc gccgctgcca ggcctctggc tgctgaggag aagcaggccc    840

agtcgctgca accatccagc agccgccgca gcagccatta cccggctgcg gtccagagcc    900

aagcggcggc agagcgaggg gcatcagcta ccgccaagtc cagagccatt tccatcctgc    960

agaagaagcc ccgccaccag cagcttctgc catctctctc ctcctttttc ttcagccaca   1020

ggctcccaga catgacagcc atcatcaaag agatcgttag cagaaacaaa aggagatatc   1080

aagaggatgg attcgactta gacttgacct atatttatcc aaacattatt gctatgggat   1140

ttcctgcaga aagacttgaa ggcgtataca ggaacaatat tgatgatgta gtaaggtttt   1200

tggattcaaa gcataaaaac cattacaaga tatacaatct ttgtgctgaa agacattatg   1260

acaccgccaa atttaattgc agagttgcac aatatccttt tgaagaccat aacccaccac   1320

agctagaact tatcaaaccc ttttgtgaag atcttgacca atggctaagt gaagatgaca   1380

atcatgttgc agcaattcac tgtaaagctg gaaagggacg aactggtgta atgatatgtg   1440

catatttatt acatcggggc aaatttttaa aggcacaaga ggccctagat ttctatgggg   1500

aagtaaggac cagagacaaa aagggagtaa ctattcccag tcagaggcgc tatgtgtatt   1560

attatagcta cctgttaaag aatcatctgg attatagacc agtggcactg ttgtttcaca   1620

agatgatgtt tgaaactatt ccaatgttca gtggcggaac ttgcaatcct cagtttgtgg   1680

tctgccagct aaaggtgaag atatattcct ccaattcagg acccacacga cgggaagaca   1740

agttcatgta ctttgagttc cctcagccgt tacctgtgtg tggtgatatc aaagtagagt   1800

tcttccacaa acagaacaag atgctaaaaa aggacaaaat gtttcacttt tgggtaaata   1860

cattcttcat accaggacca gaggaaacct cagaaaaagt agaaaatgga agtctatgtg   1920

atcaagaaat cgatagcatt tgcagtatag agcgtgcaga taatgacaag gaatatctag   1980

tacttacttt aacaaaaaat gatcttgaca aagcaaataa agacaaagcc aaccgatact   2040

tttctccaaa ttttaaggtg aagctgtact tcacaaaaac agtagaggag ccgtcaaatc   2100

cagaggctag cagttcaact tctgtaacac cagatgttag tgacaatgaa cctgatcatt   2160

atagatattc tgacaccact gactctgatc cagagaatga accttttgat gaagatcagc   2220

atacacaaat tacaaaagtc tgaatttttt tttatcaaga gggataaaac accatgaaaa   2280

taaacttgaa taaactgaaa atggaccttt ttttttttaa tggcaatagg acattgtgtc   2340

agattaccag ttataggaac aattctcttt tcctgaccaa tcttgtttta ccctatacat   2400

ccacagggtt ttgacacttg ttgtccagtt gaaaaaaggt tgtgtagctg tgtcatgtat   2460

ataccttttt gtgtcaaaag gacatttaaa attcaattag gattaataaa gatggcactt   2520

tcccgtttta ttccagtttt ataaaaagtg gagacagact gatgtgtata cgtaggaatt   2580

ttttcctttt gtgttctgtc accaactgaa gtggctaaag agctttgtga tatactggtt   2640

cacatcctac ccctttgcac ttgtggcaac agataagttt gcagttggct aagagaggtt   2700

tccgaagggt tttgctacat tctaatgcat gtattcgggt taggggaatg gagggaatgc   2760

tcagaaagga aataatttta tgctggactc tggaccatat accatctcca gctatttaca   2820

cacacctttc tttagcatgc tacagttatt aatctggaca ttcgaggaat tggccgctgt   2880

cactgcttgt tgtttgcgca ttttttttta aagcatattg gtgctagaaa aggcagctaa   2940

aggaagtgaa tctgtattgg ggtacaggaa tgaaccttct gcaacatctt aagatccaca   3000

aatgaaggga tataaaaata atgtcatagg taagaaacac agcaacaatg acttaaccat   3060

ataaatgtgg aggctatcaa caaagaatgg gcttgaaaca ttataaaaat tgacaatgat   3120

ttattaaata tgttttctca attgtaacga cttctccatc tcctgtgtaa tcaaggccag   3180

tgctaaaatt cagatgctgt tagtacctac atcagtcaac aacttacact tattttacta   3240

gttttcaatc ataatacctg ctgtggatgc ttcatgtgct gcctgcaagc ttcttttttc   3300

tcattaaata taaaatattt tgtaatgctg cacagaaatt ttcaatttga gattctacag   3360

taagcgtttt ttttctttga agatttatga tgcacttatt caatagctgt cagccgttcc   3420

acccttttga ccttacacat tctattacaa tgaattttgc agttttgcac attttttaaa   3480

tgtcattaac tgttagggaa ttttacttga atactgaata catataatgt ttatattaaa   3540

aaggacattt gtgttaaaaa ggaaattaga gttgcagtaa actttcaatg ctgcacacaa   3600

aaaaaagaca tttgattttt cagtagaaat tgtcctacat gtgctttatt gatttgctat   3660

tgaaagaata gggttttttt tttttttttt tttttttttt ttaaatgtgc agtgttgaat   3720

catttcttca tagtgctccc ccgagttggg actagggctt caatttcact tcttaaaaaa   3780

aatcatcata tatttgatat gcccagactg catacgattt taagcggagt acaactacta   3840

ttgtaaagct aatgtgaaga tattattaaa aaggtttttt tttccagaaa tttggtgtct   3900

tcaaattata ccttcacctt gacatttgaa tatccagcca ttttgtttct taatggtata   3960

aaattccatt ttcaataact tattggtgct gaaattgttc actagctgtg gtctgaccta   4020

gttaatttac aaatacagat tgaataggac ctactagagc agcatttata gagtttgatg   4080

gcaaatagat taggcagaac ttcatctaaa atattcttag taaataatgt tgacacgttt   4140

tccatacctt gtcagtttca ttcaacaatt tttaaatttt taacaaagct cttaggattt   4200

acacatttat atttaaacat tgatatatag agtattgatt gattgctcat aagttaaatt   4260

ggtaaagtta gagacaacta ttctaacacc tcaccattga aatttatatg ccaccttgtc   4320

tttcataaaa gctgaaaatt gttacctaaa atgaaaatca acttcatgtt ttgaagatag   4380

ttataaatat tgttctttgt tacaatttcg ggcaccgcat attaaaacgt aactttattg   4440

ttccaatatg taacatggag ggccaggtca taaataatga cattataatg ggcttttgca   4500

ctgttattat ttttcctttg gaatgtgaag gtctgaatga gggttttgat tttgaatgtt   4560

tcaatgtttt tgagaagcct tgcttacatt ttatggtgta gtcattggaa atggaaaaat   4620

ggcattatat atattatata tataaatata tattatacat actctcctta ctttatttca   4680

gttaccatcc ccatagaatt tgacaagaat tgctatgact gaaaggtttt cgagtcctaa   4740

ttaaaacttt atttatggca gtattcataa ttagcctgaa atgcattctg taggtaatct   4800

ctgagtttct ggaatatttt cttagacttt ttggatgtgc agcagcttac atgtctgaag   4860

ttacttgaag gcatcacttt taagaaagct tacagttggg ccctgtacca tcccaagtcc   4920

tttgtagctc ctcttgaaca tgtttgccat acttttaaaa gggtagttga ataaatagca   4980

tcaccattct ttgctgtggc acaggttata aacttaagtg gagtttaccg gcagcatcaa   5040

atgtttcagc tttaaaaaat aaaagtaggg tacaagttta atgtttagtt ctagaaattt   5100

tgtgcaatat gttcataacg atggctgtgg ttgccacaaa gtgcctcgtt tacctttaaa   5160

tactgttaat gtgtcatgca tgcagatgga aggggtggaa ctgtgcacta aagtgggggc   5220

tttaactgta gtatttggca gagttgcctt ctacctgcca gttcaaaagt tcaacctgtt   5280

ttcatataga atatatatac taaaaaattt cagtctgtta aacagcctta ctctgattca   5340

gcctcttcag atactcttgt gctgtgcagc agtggctctg tgtgtaaatg ctatgcactg   5400

aggatacaca aaaataccaa tatgatgtgt acaggataat gcctcatccc aatcagatgt   5460

ccatttgtta ttgtgtttgt taacaaccct ttatctctta gtgttataaa ctccacttaa   5520

aactgattaa agtctcattc ttgtcaaaaa aaaaaaaaaa aaaaaaaaaa aa           5572


<210>  799
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  799

Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr 
1               5                   10                  15


Gln Glu Asp Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile 
            20                  25                  30


Ile Ala Met Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn 
        35                  40                  45


Asn Ile Asp Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His 
    50                  55                  60


Tyr Lys Ile Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys 
65                  70                  75                  80


Phe Asn Cys Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro 
                85                  90                  95


Gln Leu Glu Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu 
            100                 105                 110


Ser Glu Asp Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys 
        115                 120                 125


Gly Arg Thr Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys 
    130                 135                 140


Phe Leu Lys Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr 
145                 150                 155                 160


Arg Asp Lys Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr 
                165                 170                 175


Tyr Tyr Ser Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala 
            180                 185                 190


Leu Leu Phe His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly 
        195                 200                 205


Gly Thr Cys Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile 
    210                 215                 220


Tyr Ser Ser Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr 
225                 230                 235                 240


Phe Glu Phe Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu 
                245                 250                 255


Phe Phe His Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His 
            260                 265                 270


Phe Trp Val Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu 
        275                 280                 285


Lys Val Glu Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys 
    290                 295                 300


Ser Ile Glu Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu 
305                 310                 315                 320


Thr Lys Asn Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr 
                325                 330                 335


Phe Ser Pro Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu 
            340                 345                 350


Glu Pro Ser Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp 
        355                 360                 365


Val Ser Asp Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp 
    370                 375                 380


Ser Asp Pro Glu Asn Glu Pro Phe Asp Glu Asp Gln His Thr Gln Ile 
385                 390                 395                 400


Thr Lys Val 



<210>  800
<211>  4851
<212>  DNA
<213>  Homo sapiens

<400>  800
ggcggaggga gctggagctg tcacagtccc cgggtgcgcc tgaccgagcc aagtggggtg     60

tcatggccgc ggggggcagc ggctgcactt cctcagcggg cggcggcggc cggggagtta    120

atcctcgacg cacgggtcgg tgtgtcccgt ttccctctgt gcggcggccg gcgggaccat    180

aagggcttaa ctcatatatt taacccccct ccaaaaaggt ttgaaagtat tcttgaaggg    240

ctgtttggac ctgcattatt aaaagatctc agtttattta aagactgtga acctgaaagc    300

atttctgatt ggacttttga tgaaaactgt ttattctgtt gcttgagaag agataaagta    360

aagggacact tagtcggtct ggatgaacca gcttcgggag ctgggcaaga agctctgctt    420

aaacaagagc aagcaaaaat cattcgattc gagagacaag cagaagaatt cctcaatgca    480

gtcttttata gaaaagacag tccctgggtc tccgacccca atattcccct agtggcccgt    540

gagatcatgc agcgaatgat ccaacaattt gctgctgaat atacctcaaa aaatagctct    600

actcaggacc ccagccagcc caatagcaca aagaaccaaa gcctgccgaa agcatctcca    660

gtcaccacct ctcccacggc tgcaactact cagaaccctg tgctcagcaa acttctcatg    720

gctgaccaag actcacctct ggaccttact gtcagaaagt ctcagtcaga acctagcgaa    780

caagacggtg tacttgatct gtccactaag aaaagtccat gtgctggcag cacttccctg    840

agccactctc caggctgctc cagtactcaa gggaacgggc gacctgggag acccagccag    900

taccgcccag acggacttcg gagtggtgat ggggtacctc caagaagctt acaggatgga    960

accagggaag gttttggaca ctccacatca ctcaaagttc cactggctcg atccctgcag   1020

attagtgaag aactactgag cagaaaccaa ttgtccacag ctgccagcct tgggccatct   1080

ggattacaga atcatggaca acacttaata ttatccaggg aagcctcttg ggcaaaacca   1140

cattacgagt tcaacctcag ccgtatgaag ttcaggggaa atggtgcact cagcaacatc   1200

agtgaccttc cttttcttgc agaaaactct gcctttccaa aaatggcact tcaagcaaaa   1260

caagatggaa aaaaggacgt gagccattca tctcctgtag atttaaagat accacaagtt   1320

cgaggaatgg atctttcttg ggagtctcgc actggtgatc agtacagcta tagctctttg   1380

gtaatgggtt cacaaacgga gagcgcgctt agtaaaaaat taagggctat tcttccaaaa   1440

caaagtagaa aaagcatgtt agatgctggg cccgattctt ggggctcaga tgctgagcag   1500

tctacccctg gacagccata tcccacatcg gatcaagaag gagaccctgg ctccaagcag   1560

cctcggaaga aaagagggcg ttacagacag tacaacagtg agatactgga ggaagcaatc   1620

tcagtggtta tgagtggaaa aatgagtgtt tccaaagctc agagtattta tgggattccc   1680

cacagtacac tggagtacaa agtaaaggag aggctgggca ctttgaaaaa ccctccaaag   1740

aaaaagatga aattaatgag gtcggagggg ccagatgttt ctgtaaagat tgaattagat   1800

ccccagggag aggcagcaca aagtgcaaat gaatcaaaaa acgagtagga atactgtaga   1860

gtgccaatta ctgtacaaac tgggtgagca ctactgcatc attgttcagc tatcattgct   1920

tgcacgtaat ttcatttact gtgacacttg cttctttgca gattttgcat tgacttgtgt   1980

gtacagagat gaaatgtgca ttctgaatgt tgcatatttt aaatttttca tgtgcagtat   2040

ggctcggaat atgtttggcc ttttgcatgt ttctctacaa aagagaattg agttacctca   2100

cagagaacag atacatggaa gtggactcct tgcctgtaga gcctgcatgc ttttttgttt   2160

ttttttgttg ttgttgtttt ttcttaagtt atatttgttt ttacttttta aaaaagaaga   2220

ggaaacaaag ccccctttta gaaactacgt ctgtcatact gggagcttta tcactgcaaa   2280

ttggaaagcc atcttataca aaattattca catttttcat ctacgattca actaatcgaa   2340

ggattaaact aaagaaaaaa ctaagaagaa caatgaacct ttgactttga gaaatttggt   2400

tattcactga cataattatt gggtcattta tagttacatt ttataatttt cttctcacta   2460

ttaaatttat ttaaattagc aagctattag tgctcaccca gaggggaagg tggtggaaaa   2520

tgtgcacaca ctaccttcag aaatgcttca gttaattact ttgaacacta cctttgctgt   2580

aatttcattt gagattttct aagggtagaa tttggtctca ccaacaagtg aggatatagc   2640

cttatctcat ggaggacgag ctccgtattt actcaggagc agtcagggta cattacataa   2700

aacaatggag gatgcctcat tttagcaaac taggtttctt tgtattcttc agtcctttta   2760

cagaattgat gtgctaactg aatatcattg cagcaactag actaagatat tcaagatctc   2820

tttattgggg atgggagaaa tagggaaaga aatgtgtata agtaattatg atattgcaaa   2880

agtgatactt agattttaca gcctcagtag tctgcccagt gtccacatta atgaaggatc   2940

catgtttgta gtgagagaaa aaaaccccaa ggtaacccga tatgatttag gatgcatatc   3000

agttctaaca attcaatcag aagtcaagct cattggaatt ccttttttaa ctgatccaaa   3060

tactagtaga agggggaggg agaggtgttg ggtttttttt ttaagttttt atttaatttt   3120

gttggttaga atttttttct gtttttggca tcctacataa tacccccctt cttgactttt   3180

tctgataatt agctgatatt catggttgtt tagcacacag ttcaggacct ttgagatcat   3240

gtttgtataa gcactccttg aagaatatct aagctttttc tgagatgggc ttttgaaatt   3300

ataataaggg aagtttattt tctgcggttt ttgcaagaat aagcaaagcc catggaattt   3360

aatttttcat tgtgatcaga ttaaaattac tatttgtgca aaacaaattc cacaccacat   3420

gtactgtata ttctaatctg ctgagaaagg tggtcaggcc cttctaaatg cttaaccaaa   3480

aacaaacatt attggagttt cagtgtaaaa taaaattaaa attggagggt tggttagatt   3540

gatttcagat ggatactaac agtttgaggg gaggtccaga tatttccaag gcataaattc   3600

ttgcctggaa actttggagc aattaattaa attaggttaa gttttccctc agcaacctgt   3660

gtgttcaaag gttaggcaca ccattgctgt tactaaaata catgcactgc tcattcttga   3720

catagcttgg gtgtgggttc ctcttgtttt ggttattttg tgtagcagtt taatcagtgg   3780

ataactgagc ctgtttcctc ttagctttct agacttctta acagaaaaaa cagtttgggt   3840

tcaatagcat tttatgattc tacaatattt tgtcacctag ctggaagttg caataaaaat   3900

tccttatgaa atatatggtt ttcatctgtg attgaaggaa atcatagaaa gtttgctgaa   3960

agcaaagggc taagcttatg aaggaatgcc tcctttgtta cacactcaag aatttgtcag   4020

cacacaatta attgcagcca tagtaccttt ttgcgtaacg tttgggatat tcagtagccc   4080

aggattgcta caaaaaggtc ctttgagaaa attaatttgt gcttgctttt atcccctctc   4140

agaaagacat cactaaaggc ccattaaaaa tctggcccta aaagttcaac ttttgtagag   4200

tttattgttc agagaggttt aatcctatgt ggtagtctat ataagtgatg tatgagttga   4260

gttatgtaaa ttttgtcatt gtagtgtaca tggagtgatc attttactaa cataaatatt   4320

ttctatgtgt gtttcagtgg atgacaatcg agcagcagaa gaatggtgtg cctacccttt   4380

aatgctgcag tttaagagaa cttgtattgt gtcatttcag attgtaggct gagagttgta   4440

aatagtgaaa atttgagtac ttctattatt tgttttggtt agaaagtgaa tttaaaaaac   4500

aaaccaaact ctaaactttc tcagattaaa agtcctgaga cctgaagatt gtaatattca   4560

tgtctgtgaa gcttttaaac attacacttg agatcagtca tgacttgata ttcaggtaaa   4620

ttttcttttc caagaagctt ttgaataagc atatttcctc caaaggtctc tctctttctc   4680

tctctttttt tgagtgtaga ttattttaaa gcactaattg cattacattg gtaactgcaa   4740

tataaaatag ccattattgt tttgtgaagc atggttgaaa ttagctagtg gtcccttttg   4800

aatttcatga gcctctcaaa aaagaaaaac ttaagaaaaa aaaaaaaaaa a            4851


<210>  801
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  801

Met Gln Arg Met Ile Gln Gln Phe Ala Ala Glu Tyr Thr Ser Lys Asn 
1               5                   10                  15


Ser Ser Thr Gln Asp Pro Ser Gln Pro Asn Ser Thr Lys Asn Gln Ser 
            20                  25                  30


Leu Pro Lys Ala Ser Pro Val Thr Thr Ser Pro Thr Ala Ala Thr Thr 
        35                  40                  45


Gln Asn Pro Val Leu Ser Lys Leu Leu Met Ala Asp Gln Asp Ser Pro 
    50                  55                  60


Leu Asp Leu Thr Val Arg Lys Ser Gln Ser Glu Pro Ser Glu Gln Asp 
65                  70                  75                  80


Gly Val Leu Asp Leu Ser Thr Lys Lys Ser Pro Cys Ala Gly Ser Thr 
                85                  90                  95


Ser Leu Ser His Ser Pro Gly Cys Ser Ser Thr Gln Gly Asn Gly Arg 
            100                 105                 110


Pro Gly Arg Pro Ser Gln Tyr Arg Pro Asp Gly Leu Arg Ser Gly Asp 
        115                 120                 125


Gly Val Pro Pro Arg Ser Leu Gln Asp Gly Thr Arg Glu Gly Phe Gly 
    130                 135                 140


His Ser Thr Ser Leu Lys Val Pro Leu Ala Arg Ser Leu Gln Ile Ser 
145                 150                 155                 160


Glu Glu Leu Leu Ser Arg Asn Gln Leu Ser Thr Ala Ala Ser Leu Gly 
                165                 170                 175


Pro Ser Gly Leu Gln Asn His Gly Gln His Leu Ile Leu Ser Arg Glu 
            180                 185                 190


Ala Ser Trp Ala Lys Pro His Tyr Glu Phe Asn Leu Ser Arg Met Lys 
        195                 200                 205


Phe Arg Gly Asn Gly Ala Leu Ser Asn Ile Ser Asp Leu Pro Phe Leu 
    210                 215                 220


Ala Glu Asn Ser Ala Phe Pro Lys Met Ala Leu Gln Ala Lys Gln Asp 
225                 230                 235                 240


Gly Lys Lys Asp Val Ser His Ser Ser Pro Val Asp Leu Lys Ile Pro 
                245                 250                 255


Gln Val Arg Gly Met Asp Leu Ser Trp Glu Ser Arg Thr Gly Asp Gln 
            260                 265                 270


Tyr Ser Tyr Ser Ser Leu Val Met Gly Ser Gln Thr Glu Ser Ala Leu 
        275                 280                 285


Ser Lys Lys Leu Arg Ala Ile Leu Pro Lys Gln Ser Arg Lys Ser Met 
    290                 295                 300


Leu Asp Ala Gly Pro Asp Ser Trp Gly Ser Asp Ala Glu Gln Ser Thr 
305                 310                 315                 320


Pro Gly Gln Pro Tyr Pro Thr Ser Asp Gln Glu Gly Asp Pro Gly Ser 
                325                 330                 335


Lys Gln Pro Arg Lys Lys Arg Gly Arg Tyr Arg Gln Tyr Asn Ser Glu 
            340                 345                 350


Ile Leu Glu Glu Ala Ile Ser Val Val Met Ser Gly Lys Met Ser Val 
        355                 360                 365


Ser Lys Ala Gln Ser Ile Tyr Gly Ile Pro His Ser Thr Leu Glu Tyr 
    370                 375                 380


Lys Val Lys Glu Arg Leu Gly Thr Leu Lys Asn Pro Pro Lys Lys Lys 
385                 390                 395                 400


Met Lys Leu Met Arg Ser Glu Gly Pro Asp Val Ser Val Lys Ile Glu 
                405                 410                 415


Leu Asp Pro Gln Gly Glu Ala Ala Gln Ser Ala Asn Glu Ser Lys Asn 
            420                 425                 430


Glu 



<210>  802
<211>  3313
<212>  DNA
<213>  Homo sapiens

<400>  802
gcgccgagcg cgggtttccg ctcggggcgg gcgatagaga cagcgcgtcg cgcctttagc     60

ttctttccca gactccggcc cagctcctgc gatctccaca gcagcctctg aggccgcccc    120

cagagagcat caggatggct gaggaaaagg gtggaaagca agtcctggaa gaatctgcat    180

ttgaagaaat ggaaagagat tttcagggag ttctccatga actttctgga gacaaaagtt    240

tggaaaaatt tcggattgaa tatgagaggc ttcatgctgt catgaaaaag tcttatgaca    300

atgaaaagcg tctgatggcc aaatgcagag agctaaatgc agagattgta gtgaattctg    360

cgaaggtcgc cactgccctt aagctctctc aggatgatca gaccaccatt gcatccctaa    420

agaaggaaat tgaaaaggcc tggaagatgg tggactcagc ctatgacaaa gagcagaagg    480

ccaaggagac gattcttgct ctgaaagagg aaatagtgaa cctgaccaaa ctagtggagc    540

aggggtctgg actgtcaatg gaccagcata gcaacatccg agatttactg aggttcaaag    600

aagaagtgac aaaggagaga gaccagctct tatcagaagt ggtaaaatta cgagaatccc    660

tagctcagac cactgaacag cagcaggaaa cagagcgatc aaaagaggag gctgaacatg    720

ccatcagtca gttccaacaa gaaatccagc aacgtcagaa cgaagcttcc cgggagttcc    780

ggaagaagga aaaactagag aaagagctca agcagattca ggcagacatg gacagcaggc    840

agacagaaat aaaagccctg cagcagtatg tgcagaagag caaggaggag cttcagaagc    900

tggagcagca gctgaaggag cagaagatat tgaatgagag agctgcaaag gaactcgagc    960

aatttcagat gagaaatgct aaacttcagc aagagaatga acagcacagt ttggtctgtg   1020

agcagctatc ccaggaaaac caacagaagg cgttggagct caaagccaaa gaggaagaag   1080

tccatcaaat gcgccttgac atcgggaagc tcaacaaaat cagagaacaa attcataaga   1140

aattgcacca caccgaagat caaaaggcag aagtcgaaca gcacaaagaa accctaaaaa   1200

atcagattgt gggattagag agagaggtag aggcttcaaa gaaacaagca gaacttgaca   1260

gaaaggcaat ggacgagctt ctaagagaaa gggacatact aaataagaac atgcttaagg   1320

cggtcaatgc gacccagaag cagacagact tggtaaagct ccatgaacaa gccaagagga   1380

acctggaggg agaaatccag aactacaagg atgaggctca gaagcagaga aagatcatct   1440

ttcatctgga aaaggagcgt gaccggtaca tcaaccaagc cagtgacctt acgcaaaagg   1500

tccttatgaa catggaagac ataaaagttc gtgaaacaca gatttttgac tacaggaaaa   1560

aaatagctga atcagagatt aaattaaaac agcaacagaa cctatatgaa gctgtgagat   1620

cagacagaaa tctgtatagc aaaaatctgg ttgaggctca ggatgaaata acagatatga   1680

agagaaagtt aaagattatg atccatcagg tagatgagct gaaagaagac atctctgcca   1740

aagagtccgc acttgtgaag ctgcacctgg aacagcagcg aatagaaaag gaaaaggaaa   1800

cattgaaggc tgagctgcag aagctgagac aacaagccct ggagacaaaa cactttattg   1860

aaaagcaaga agctgaagag agaaaactcc tgcgaataat tgctgaggct gacggggaga   1920

ggttgagaca gaagaaggaa ttagaccagg tcatcagtga gagagatatc ctggggtctc   1980

agcttgttcg gcgcaatgat gagttagctt tgctctatga gaagatcaag atccaacagt   2040

ctgtgctgaa taaaggggag agccagtaca accagaggtt ggaggacatg agaatcctca   2100

gacttgagat caagaagctt cgccgggaaa aggggattct tgccaggagt atggctaatg   2160

ttgaagaact cagacaggag ttttttcaca tgcaaagaga attgttgaag gagaggacac   2220

gctgccgagc cctggaggag gagctggaga atcccctgaa tgtgcacaga tggaggaagc   2280

tcgaggccag cgaccccaat gcatatgagc tgatacagaa aattcacacc ctgcagaagc   2340

gtctcatcag caagactgaa gaggtggttg aaaaagagct gctcctccag gaaaaggaga   2400

aactctacat ggaactaaag cacgtcttgg cccgccagcc tggacctgag gctgcggaac   2460

agctgaagct gtaccgacgc acgctgcatg acaagaagca gcagctgaaa gttttgtctt   2520

cagaattgaa tatgtatgaa gtacagagca aagaatataa atatgaggta gagaaactta   2580

ccaatgagct ccagaattta aagaagaaat acctcgctca gaaacgtaaa gaacaacttc   2640

aaaaaaacaa ggacacagca cccatggata acaccttctt aatggtcaaa ccaaatggtc   2700

ctggttttac tgggggcgga tttcctctca ggtcaaccaa aatgacgttc taacctgaag   2760

ctgctggctg tttccagttg aacaactcat gaaatctgct ctgggacatt ttgggggaat   2820

ctcaaagtcc ttggatcata gaactgagtg ctgagaatcc aggatggaaa gaaatgcaga   2880

actatcatag tcacatacat ataagaggga tggtgttttg tctggttcac gttgatatta   2940

acagatcata attctctctg ttcagttagg ctgacctatt gcatgaagca aatcttttgt   3000

tgctacccca ttgattgaaa tgtactagac cttaatttct ttattacaga cattggtgta   3060

cttgaaggtt ttatatttaa aagtattttt gaaatgcaat gtgtcccctc tcaccttatt   3120

aacaataatc tattttaatt attcctcatt aacaagtcat tgcatgagat gagaaagaag   3180

gacaaactct taagaattta aaaagtgttt tgagaatgat ttctatatgg aatttctttt   3240

caggcccgga atgggaaaat ctattccaaa gagacacact aataaatact tcattataaa   3300

aaataaaaaa gaa                                                      3313


<210>  803
<211>  872
<212>  PRT
<213>  Homo sapiens

<400>  803

Met Ala Glu Glu Lys Gly Gly Lys Gln Val Leu Glu Glu Ser Ala Phe 
1               5                   10                  15


Glu Glu Met Glu Arg Asp Phe Gln Gly Val Leu His Glu Leu Ser Gly 
            20                  25                  30


Asp Lys Ser Leu Glu Lys Phe Arg Ile Glu Tyr Glu Arg Leu His Ala 
        35                  40                  45


Val Met Lys Lys Ser Tyr Asp Asn Glu Lys Arg Leu Met Ala Lys Cys 
    50                  55                  60


Arg Glu Leu Asn Ala Glu Ile Val Val Asn Ser Ala Lys Val Ala Thr 
65                  70                  75                  80


Ala Leu Lys Leu Ser Gln Asp Asp Gln Thr Thr Ile Ala Ser Leu Lys 
                85                  90                  95


Lys Glu Ile Glu Lys Ala Trp Lys Met Val Asp Ser Ala Tyr Asp Lys 
            100                 105                 110


Glu Gln Lys Ala Lys Glu Thr Ile Leu Ala Leu Lys Glu Glu Ile Val 
        115                 120                 125


Asn Leu Thr Lys Leu Val Glu Gln Gly Ser Gly Leu Ser Met Asp Gln 
    130                 135                 140


His Ser Asn Ile Arg Asp Leu Leu Arg Phe Lys Glu Glu Val Thr Lys 
145                 150                 155                 160


Glu Arg Asp Gln Leu Leu Ser Glu Val Val Lys Leu Arg Glu Ser Leu 
                165                 170                 175


Ala Gln Thr Thr Glu Gln Gln Gln Glu Thr Glu Arg Ser Lys Glu Glu 
            180                 185                 190


Ala Glu His Ala Ile Ser Gln Phe Gln Gln Glu Ile Gln Gln Arg Gln 
        195                 200                 205


Asn Glu Ala Ser Arg Glu Phe Arg Lys Lys Glu Lys Leu Glu Lys Glu 
    210                 215                 220


Leu Lys Gln Ile Gln Ala Asp Met Asp Ser Arg Gln Thr Glu Ile Lys 
225                 230                 235                 240


Ala Leu Gln Gln Tyr Val Gln Lys Ser Lys Glu Glu Leu Gln Lys Leu 
                245                 250                 255


Glu Gln Gln Leu Lys Glu Gln Lys Ile Leu Asn Glu Arg Ala Ala Lys 
            260                 265                 270


Glu Leu Glu Gln Phe Gln Met Arg Asn Ala Lys Leu Gln Gln Glu Asn 
        275                 280                 285


Glu Gln His Ser Leu Val Cys Glu Gln Leu Ser Gln Glu Asn Gln Gln 
    290                 295                 300


Lys Ala Leu Glu Leu Lys Ala Lys Glu Glu Glu Val His Gln Met Arg 
305                 310                 315                 320


Leu Asp Ile Gly Lys Leu Asn Lys Ile Arg Glu Gln Ile His Lys Lys 
                325                 330                 335


Leu His His Thr Glu Asp Gln Lys Ala Glu Val Glu Gln His Lys Glu 
            340                 345                 350


Thr Leu Lys Asn Gln Ile Val Gly Leu Glu Arg Glu Val Glu Ala Ser 
        355                 360                 365


Lys Lys Gln Ala Glu Leu Asp Arg Lys Ala Met Asp Glu Leu Leu Arg 
    370                 375                 380


Glu Arg Asp Ile Leu Asn Lys Asn Met Leu Lys Ala Val Asn Ala Thr 
385                 390                 395                 400


Gln Lys Gln Thr Asp Leu Val Lys Leu His Glu Gln Ala Lys Arg Asn 
                405                 410                 415


Leu Glu Gly Glu Ile Gln Asn Tyr Lys Asp Glu Ala Gln Lys Gln Arg 
            420                 425                 430


Lys Ile Ile Phe His Leu Glu Lys Glu Arg Asp Arg Tyr Ile Asn Gln 
        435                 440                 445


Ala Ser Asp Leu Thr Gln Lys Val Leu Met Asn Met Glu Asp Ile Lys 
    450                 455                 460


Val Arg Glu Thr Gln Ile Phe Asp Tyr Arg Lys Lys Ile Ala Glu Ser 
465                 470                 475                 480


Glu Ile Lys Leu Lys Gln Gln Gln Asn Leu Tyr Glu Ala Val Arg Ser 
                485                 490                 495


Asp Arg Asn Leu Tyr Ser Lys Asn Leu Val Glu Ala Gln Asp Glu Ile 
            500                 505                 510


Thr Asp Met Lys Arg Lys Leu Lys Ile Met Ile His Gln Val Asp Glu 
        515                 520                 525


Leu Lys Glu Asp Ile Ser Ala Lys Glu Ser Ala Leu Val Lys Leu His 
    530                 535                 540


Leu Glu Gln Gln Arg Ile Glu Lys Glu Lys Glu Thr Leu Lys Ala Glu 
545                 550                 555                 560


Leu Gln Lys Leu Arg Gln Gln Ala Leu Glu Thr Lys His Phe Ile Glu 
                565                 570                 575


Lys Gln Glu Ala Glu Glu Arg Lys Leu Leu Arg Ile Ile Ala Glu Ala 
            580                 585                 590


Asp Gly Glu Arg Leu Arg Gln Lys Lys Glu Leu Asp Gln Val Ile Ser 
        595                 600                 605


Glu Arg Asp Ile Leu Gly Ser Gln Leu Val Arg Arg Asn Asp Glu Leu 
    610                 615                 620


Ala Leu Leu Tyr Glu Lys Ile Lys Ile Gln Gln Ser Val Leu Asn Lys 
625                 630                 635                 640


Gly Glu Ser Gln Tyr Asn Gln Arg Leu Glu Asp Met Arg Ile Leu Arg 
                645                 650                 655


Leu Glu Ile Lys Lys Leu Arg Arg Glu Lys Gly Ile Leu Ala Arg Ser 
            660                 665                 670


Met Ala Asn Val Glu Glu Leu Arg Gln Glu Phe Phe His Met Gln Arg 
        675                 680                 685


Glu Leu Leu Lys Glu Arg Thr Arg Cys Arg Ala Leu Glu Glu Glu Leu 
    690                 695                 700


Glu Asn Pro Leu Asn Val His Arg Trp Arg Lys Leu Glu Ala Ser Asp 
705                 710                 715                 720


Pro Asn Ala Tyr Glu Leu Ile Gln Lys Ile His Thr Leu Gln Lys Arg 
                725                 730                 735


Leu Ile Ser Lys Thr Glu Glu Val Val Glu Lys Glu Leu Leu Leu Gln 
            740                 745                 750


Glu Lys Glu Lys Leu Tyr Met Glu Leu Lys His Val Leu Ala Arg Gln 
        755                 760                 765


Pro Gly Pro Glu Ala Ala Glu Gln Leu Lys Leu Tyr Arg Arg Thr Leu 
    770                 775                 780


His Asp Lys Lys Gln Gln Leu Lys Val Leu Ser Ser Glu Leu Asn Met 
785                 790                 795                 800


Tyr Glu Val Gln Ser Lys Glu Tyr Lys Tyr Glu Val Glu Lys Leu Thr 
                805                 810                 815


Asn Glu Leu Gln Asn Leu Lys Lys Lys Tyr Leu Ala Gln Lys Arg Lys 
            820                 825                 830


Glu Gln Leu Gln Lys Asn Lys Asp Thr Ala Pro Met Asp Asn Thr Phe 
        835                 840                 845


Leu Met Val Lys Pro Asn Gly Pro Gly Phe Thr Gly Gly Gly Phe Pro 
    850                 855                 860


Leu Arg Ser Thr Lys Met Thr Phe 
865                 870


<210>  804
<211>  7108
<212>  DNA
<213>  Homo sapiens

<400>  804
atgtgggacc agtgtgggaa ggtcttgttt atgtgggagg ggggaccaca gataacaaag     60

aacagcccct tgcccccctc attgaaaacc agctgtgcat ctagacctct gtcttcccac    120

agtgccgcca agctcctgga caagaaccca ttctcggtca gtaacccgaa ccctctgctt    180

ccttcacctg ccagtctcca gctggctcaa ctgcaggccc agctcaccct ccaccggctg    240

aagctggcac agacagctgt caccaacaac actgcagccg ccacagtcct gaaccaagtc    300

ctctccaaag tggccatgtc ccagcctctc ttcaatcaac tgaggcatcc gtctgtgatc    360

actggccccc acggccatgc tggggttccc caacatgctg cagccatacc cagtacccgg    420

tttccctcta atgcaattgc cttttcaccc cccagccaga cacgaggccc cggaccctcc    480

atgaaccttc ccaaccagcc acccagtgcc atggtgatgc atcctttcac tggggtaatg    540

cctcagaccc ctggccagcc agcagtcatc ttgggcattg gcaagactgg gcctgctcca    600

gctacagcag gattctatga gtatggcaaa gccagctctg gccagacata tggccctgaa    660

acagatggtc agcctggctt cctgccatcc tcggcctcaa cctcgggcag tgtgacctat    720

gaagggcact acagccacac agggcaggat ggtcaagctg ccttttccaa agatttttac    780

ggacccaact cccaaggttc acatgtggcc agcggatttc cagctgagca ggctgggggc    840

ctgaaaagtg aggtcgggcc actgctgcag ggcacaaaca gccaatggga gagcccccat    900

ggattctcgg gccaaagcaa gcctgatctc acagcaggtc ccatgtggcc tccaccccac    960

aaccagccct atgagctgta cgaccccgag gaaccaacct cagacaggac acctccttcc   1020

ttcgggggtc ggcttaacaa cagcaaacag ggttttatcg gtgctgggcg gagggccaag   1080

gaggaccagg cgttgctatc tgtgcggccc ctgcaggctc atgagctgaa cgactttcac   1140

ggtgtggccc ccctccactt gccgcatatc tgtagcatct gtgacaagaa ggtgtttgat   1200

ttgaaggact gggagctgca tgtgaaaggg aagctgcacg ctcagaaatg cctggtcttc   1260

tctgaaaatg ctggcatccg gtgtatactt ggttcggcag agggaacatt gtgtgcttct   1320

cccaacagca cagctgttta taaccctgct gggaatgaag attatgcctc aaatcttgga   1380

acatcatacg tgcccattcc agcaaggtca ttcactcagt caagccccac atttcctttg   1440

gcttctgtgg ggacaacttt tgcacagcgg aaaggggctg gccgtgtggt gcacatctgc   1500

aatctccctg aaggaagctg cactgagaat gacgtcatta acctggggct gccctttgga   1560

aaggtcacta attacatcct catgaagtcg actaatcagg cctttttaga gatggcttac   1620

acagaagctg cacaggccat ggtccagtat tatcaagaaa aatctgctgt gatcaatggt   1680

gagaagttgc tcattcggat gtccaagaga tacaaggaat tgcagctcaa gaaacccggg   1740

aaggccgtgg ctgccatcat ccaggacatc cattcccaga gggagaggga catgttccgg   1800

gaagcagaca gatatggccc agaaaggccg cggtctcgta gtccggtgag ccggtcactc   1860

tccccgaggt cccacactcc cagcttcacc tcctgcagct cttcccacag ccctccgggc   1920

ccctcccggg ctgactgggg caatggccgg gactcctggg agcactctcc ctatgccagg   1980

agggaggaag agcgagaccc ggctccctgg agggacaacg gagatgacaa gagggacagg   2040

atggacccct gggcacatga tcgcaaacac cacccccggc aactggacaa ggctgagttg   2100

gacgagcgac cagaaggagg gaggccccac cgggagaagt acccgagatc tgggtctccc   2160

aacctgcccc actctgtgtc cagctacaaa agccgtgaag acggctacta ccggaaagag   2220

cccaaagcca agtgggacaa gtatctgaag cagcagcagg atgcccccgg gaggtccagg   2280

aggaaagacg aggccaggct gcgggaaagc agacaccccc atccggatga ctcaggcaag   2340

gaagatgggc tggggccaaa ggtcactagg gcccctgagg gcgccaaggc caagcagaat   2400

gagaaaaata aaaccaagag aactgataga gaccaagaag gagctgatga tagaaaagaa   2460

aacacaatgg cagagaatga ggctggaaaa gaggaacagg agggcatgga agaaagccct   2520

caatcagtgg gcagacagga gaaagaagca gagttctctg atccggaaaa cacaaggaca   2580

aagaaggaac aagattggga gagtgaaagt gaggcagagg gggagagctg gtatcccact   2640

aacatggagg agctggtgac agtggacgag gttggggaag aagaagattt tatcgtggaa   2700

ccagacatcc cagagctgga agaaattgtg cccattgacc agaaagacaa aatttgccca   2760

gaaacatgtc tgtgtgtgac aaccacctta gacttagacc tggcccagga tttccccaag   2820

gaaggagtca aggccgtagg gaatggggct gcagaaatca gcctcaagtc acccagagaa   2880

ctgccctctg cttccacaag ctgtcccagt gacatggacg tggaaatgcc tggcctaaat   2940

ctggatgctg agcggaagcc agctgaaagt gagacaggcc tctccctgga ggattcagat   3000

tgctacgaga aggaggcaaa gggagtggag agctcagatg ttcatccagc ccctacagtc   3060

cagcaaatgt cttcccctaa gccagcagag gagagggccc ggcagccaag cccatttgtg   3120

gatgattgca agaccagggg gacccccgaa gatggggctt gtgaaggcag ccccctggag   3180

gagaaagcca gcccccccat cgaaactgac ctccaaaacc aagcttgcca agaagtgttg   3240

accccggaaa actccaggta cgtggaaatg aaatctctgg aggtgaggtc accagagtac   3300

actgaagtgg aactgaaaca gcccctttct ttgccctctt gggaaccaga ggatgtgttc   3360

agtgaactta gcattcctct aggggtggag ttcgtggttc ccaggactgg cttttattgc   3420

aagctgtgtg ggctgttcta cacgagcgag gagacagcaa agatgagcca ctgccgcagc   3480

gctgtccact acaggaactt acagaaatat ttgtcccagc tggccgagga gggcctcaag   3540

gagaccgagg gggcagatag cccgaggcca gaggacagcg gaatcgtgcc acgcttcgaa   3600

aggaaaaagc tctgatgctt ctgcttctgc tgctactgct gctgctgcaa ggttggaaag   3660

gagagcttgc tgaagtgggg ccttcctgat tctggggaca ggactaaagc ctgagaggaa   3720

ggaaaaccaa gcagggcaca ttgcttgggc ttgttcccag agactcagtg aaatgcccct   3780

gatatgtctc caggagcaag tcacccaggt gtgtccagcc cactgagggt caccaactct   3840

ctccctgctg actcttgttt ctctcaatct ttcaattcgt ttttctctct tttcctcttg   3900

ttctttctct ccctccctcc ttatgtgcca aggatcgttt ccttttcaca aaacccaact   3960

tctcagggat tttcacagtg tttaaattct tggtaggata taacaggtca ggcctagctg   4020

agtcaggcaa ggaaaaggtt taatggaaac tcctgggtca ggcgaacccc tgcagtgagt   4080

ctacagcagt atctctgcct ggtgtcccat gtatcccctg catgaggagc tgagtcaggt   4140

ctgcagtcct ggtgagggga catcacggac aatctgttgg cagagctggg agggtcttca   4200

ttaacctctt cctccaactg ggccaccctt ttgaaaagcc cctgttttta ataactgttt   4260

catcctctca gttattctag aaatctgcca gacttatgcc ttaaagtaaa attaaatgaa   4320

ttttagagaa gatgaaaaga gcccttcatt ttggaagctc tgataagttt cctccaaact   4380

tattcccctc ctcttgattt caggagatgt cagggttttt ctattctgga caatgaattt   4440

ggtacagagt cactgtaatt aaatataaaa acagaagcat cttcctccag ctaaagcagc   4500

agttggcgcg ggcttaggtt gaatgctggc ctctctgcaa agcacagctt tggctcgaga   4560

ggcacagctc caggctgtgg aaaacagagt tgtcttgggg gttaaatgag cttatttaag   4620

tcaaggaaac atcatctgtc cttgattcag ccttggtgcc tgcactctgg ggtacaacca   4680

cctcacagta ggatggtttt taaatggccc cccagttggg ggagaagcta aggaaagaga   4740

aggctgcaga tccaaagagt ggcattgaag tttgctgggt gtctgtaggt ggaccctttc   4800

cagctgggca gatagttgag ggctccctgg gtttgactgt atgtgcagac tttgatacca   4860

aaatgttatg aaaagtcgtg attcccgctg ctctttctgg tactggaggg tgggtacctt   4920

caggctgtgg ggtctctagc ctgatattcc attgaaaggg tgtgggataa aggtgctggg   4980

ggaaatgagg ctctgccaca gccatagaga ggccctcggg cagttaagaa gggagcctgg   5040

agctgttttc atgagcagag atactctcct gaaagcaccc ttcatagctt agcccaggaa   5100

aaataaaaca aggaagacag gtcactctcc cctaggcagt tcctgttgtt tctgttcctg   5160

accttgggca ggcagactga gaagggactg tgtagggttt tgttttgttt tttttcattt   5220

tcctttttat ggcatgtgag agcatactgt acattctgtc ctctgtacta atggaggaag   5280

ggcagagaga ttagttcaag gctaacattt tatatcaggt aactgaggca cacaaaggga   5340

acaaatgaag aacataaaat gatcagtgta aacctgaaag cacgcagtca ttggcaaggg   5400

acaggctcat gggagctggt gagagagagc agttaaggca agcaccaggg gaaagcagac   5460

caacttgaac agatgtgatg cggagaggtt ggaagaagca agaaacctga actcatcatc   5520

aggctattaa ataaaattta taggaggctg ttggtttgga ctgagctcct gcaataggcc   5580

caacagacca aaacaaaagg gagtcactca tgttgaagtt ctgtcttcca ggaaatcagg   5640

agagagagag agagaaagaa tagccaaatc cccaaacagg ccagttttaa ccagcatgat   5700

gaagtgtcct tggttttaac ctttataagg aaagcagctt tgagatgacc agtctggttt   5760

ttgttctttg tgtctgcttt cctcagccct tttctgtcta taaagccaac ctcctccgct   5820

cagctcatgg gaacactcat tctattttat agaatgacat gttgcccaat tctagaatca   5880

aaaataaagg ccaactaaga tcttcaaagt aaatttgttg taattttatc ttttgagaag   5940

accatatggg ggctgctgaa aagttggtat ctcaaataaa gtctgaagat cacggctcag   6000

cccagattgt tcccctggcc aactccacag gtttgaacct ggcattctgg acaccagcta   6060

tgcctcctcc atttctcaga aaacctttga tcttgtgtgt ctttcttcct actgaaggga   6120

attgtggggg cagttctttg gccttcttgc tgaactttgc tggaaatagc ccacaatttt   6180

tatcagaggt tagaactgta cattatcaga gagactggac actttatccc ctagcaaagt   6240

gggagaagat tttaccagct cattccactc caccctggcc ttcccccacc ccccatcccc   6300

agcagcattt ccatggaaat ccagatggtc gtgtagtgtt atggctctct tgtgatagac   6360

tggccttcat attggagagc tagggagagc ccctgggagg gagagagata aggcgctatc   6420

tgccttcaat cagaaccttc ggtttaaaat catctaagag tctatacttg tgtgtacata   6480

cgtatttatt tttatttatt tttatacaat tccattggca tggtccttca ccgaccctat   6540

gatttgcact ttttatttct atgtgtgcca cacacaatgc agtattaatg gcaaccaggt   6600

aaatattgat ttatttttta aagcttttct tcagtgtttt gtcaaccatt tcaaagtgtc   6660

tcccaaaaaa ggatgctgaa gagcaattgc tcccttaagc aacagattca tatttaccct   6720

gggttaatac aacaaaaggc ctgtataatt gtcttttcat tgttaacacc caaaatagca   6780

tctatctaga cagtatcccc aaagaatttg gaaaatctga tggtgtgagc agcagccgtt   6840

agtatcaggg tttcccattc ttggacagtc cgaggctgtg acctgttaga taattagatt   6900

atacttgaac tggaccagag tttgtttttt gaatttatga gaaaaaccaa aacactaagt   6960

taagtttgaa cttgtaaagt attgaaattt gttgagtgtc ctataaattg tcactacttt   7020

tcctgatctg tataactgac tgcaaagtgt ttgtttttac aaaagagaaa agaaaagatt   7080

tttaataaag agaatttgaa agctgtga                                      7108


<210>  805
<211>  1204
<212>  PRT
<213>  Homo sapiens

<400>  805

Met Trp Asp Gln Cys Gly Lys Val Leu Phe Met Trp Glu Gly Gly Pro 
1               5                   10                  15


Gln Ile Thr Lys Asn Ser Pro Leu Pro Pro Ser Leu Lys Thr Ser Cys 
            20                  25                  30


Ala Ser Arg Pro Leu Ser Ser His Ser Ala Ala Lys Leu Leu Asp Lys 
        35                  40                  45


Asn Pro Phe Ser Val Ser Asn Pro Asn Pro Leu Leu Pro Ser Pro Ala 
    50                  55                  60


Ser Leu Gln Leu Ala Gln Leu Gln Ala Gln Leu Thr Leu His Arg Leu 
65                  70                  75                  80


Lys Leu Ala Gln Thr Ala Val Thr Asn Asn Thr Ala Ala Ala Thr Val 
                85                  90                  95


Leu Asn Gln Val Leu Ser Lys Val Ala Met Ser Gln Pro Leu Phe Asn 
            100                 105                 110


Gln Leu Arg His Pro Ser Val Ile Thr Gly Pro His Gly His Ala Gly 
        115                 120                 125


Val Pro Gln His Ala Ala Ala Ile Pro Ser Thr Arg Phe Pro Ser Asn 
    130                 135                 140


Ala Ile Ala Phe Ser Pro Pro Ser Gln Thr Arg Gly Pro Gly Pro Ser 
145                 150                 155                 160


Met Asn Leu Pro Asn Gln Pro Pro Ser Ala Met Val Met His Pro Phe 
                165                 170                 175


Thr Gly Val Met Pro Gln Thr Pro Gly Gln Pro Ala Val Ile Leu Gly 
            180                 185                 190


Ile Gly Lys Thr Gly Pro Ala Pro Ala Thr Ala Gly Phe Tyr Glu Tyr 
        195                 200                 205


Gly Lys Ala Ser Ser Gly Gln Thr Tyr Gly Pro Glu Thr Asp Gly Gln 
    210                 215                 220


Pro Gly Phe Leu Pro Ser Ser Ala Ser Thr Ser Gly Ser Val Thr Tyr 
225                 230                 235                 240


Glu Gly His Tyr Ser His Thr Gly Gln Asp Gly Gln Ala Ala Phe Ser 
                245                 250                 255


Lys Asp Phe Tyr Gly Pro Asn Ser Gln Gly Ser His Val Ala Ser Gly 
            260                 265                 270


Phe Pro Ala Glu Gln Ala Gly Gly Leu Lys Ser Glu Val Gly Pro Leu 
        275                 280                 285


Leu Gln Gly Thr Asn Ser Gln Trp Glu Ser Pro His Gly Phe Ser Gly 
    290                 295                 300


Gln Ser Lys Pro Asp Leu Thr Ala Gly Pro Met Trp Pro Pro Pro His 
305                 310                 315                 320


Asn Gln Pro Tyr Glu Leu Tyr Asp Pro Glu Glu Pro Thr Ser Asp Arg 
                325                 330                 335


Thr Pro Pro Ser Phe Gly Gly Arg Leu Asn Asn Ser Lys Gln Gly Phe 
            340                 345                 350


Ile Gly Ala Gly Arg Arg Ala Lys Glu Asp Gln Ala Leu Leu Ser Val 
        355                 360                 365


Arg Pro Leu Gln Ala His Glu Leu Asn Asp Phe His Gly Val Ala Pro 
    370                 375                 380


Leu His Leu Pro His Ile Cys Ser Ile Cys Asp Lys Lys Val Phe Asp 
385                 390                 395                 400


Leu Lys Asp Trp Glu Leu His Val Lys Gly Lys Leu His Ala Gln Lys 
                405                 410                 415


Cys Leu Val Phe Ser Glu Asn Ala Gly Ile Arg Cys Ile Leu Gly Ser 
            420                 425                 430


Ala Glu Gly Thr Leu Cys Ala Ser Pro Asn Ser Thr Ala Val Tyr Asn 
        435                 440                 445


Pro Ala Gly Asn Glu Asp Tyr Ala Ser Asn Leu Gly Thr Ser Tyr Val 
    450                 455                 460


Pro Ile Pro Ala Arg Ser Phe Thr Gln Ser Ser Pro Thr Phe Pro Leu 
465                 470                 475                 480


Ala Ser Val Gly Thr Thr Phe Ala Gln Arg Lys Gly Ala Gly Arg Val 
                485                 490                 495


Val His Ile Cys Asn Leu Pro Glu Gly Ser Cys Thr Glu Asn Asp Val 
            500                 505                 510


Ile Asn Leu Gly Leu Pro Phe Gly Lys Val Thr Asn Tyr Ile Leu Met 
        515                 520                 525


Lys Ser Thr Asn Gln Ala Phe Leu Glu Met Ala Tyr Thr Glu Ala Ala 
    530                 535                 540


Gln Ala Met Val Gln Tyr Tyr Gln Glu Lys Ser Ala Val Ile Asn Gly 
545                 550                 555                 560


Glu Lys Leu Leu Ile Arg Met Ser Lys Arg Tyr Lys Glu Leu Gln Leu 
                565                 570                 575


Lys Lys Pro Gly Lys Ala Val Ala Ala Ile Ile Gln Asp Ile His Ser 
            580                 585                 590


Gln Arg Glu Arg Asp Met Phe Arg Glu Ala Asp Arg Tyr Gly Pro Glu 
        595                 600                 605


Arg Pro Arg Ser Arg Ser Pro Val Ser Arg Ser Leu Ser Pro Arg Ser 
    610                 615                 620


His Thr Pro Ser Phe Thr Ser Cys Ser Ser Ser His Ser Pro Pro Gly 
625                 630                 635                 640


Pro Ser Arg Ala Asp Trp Gly Asn Gly Arg Asp Ser Trp Glu His Ser 
                645                 650                 655


Pro Tyr Ala Arg Arg Glu Glu Glu Arg Asp Pro Ala Pro Trp Arg Asp 
            660                 665                 670


Asn Gly Asp Asp Lys Arg Asp Arg Met Asp Pro Trp Ala His Asp Arg 
        675                 680                 685


Lys His His Pro Arg Gln Leu Asp Lys Ala Glu Leu Asp Glu Arg Pro 
    690                 695                 700


Glu Gly Gly Arg Pro His Arg Glu Lys Tyr Pro Arg Ser Gly Ser Pro 
705                 710                 715                 720


Asn Leu Pro His Ser Val Ser Ser Tyr Lys Ser Arg Glu Asp Gly Tyr 
                725                 730                 735


Tyr Arg Lys Glu Pro Lys Ala Lys Trp Asp Lys Tyr Leu Lys Gln Gln 
            740                 745                 750


Gln Asp Ala Pro Gly Arg Ser Arg Arg Lys Asp Glu Ala Arg Leu Arg 
        755                 760                 765


Glu Ser Arg His Pro His Pro Asp Asp Ser Gly Lys Glu Asp Gly Leu 
    770                 775                 780


Gly Pro Lys Val Thr Arg Ala Pro Glu Gly Ala Lys Ala Lys Gln Asn 
785                 790                 795                 800


Glu Lys Asn Lys Thr Lys Arg Thr Asp Arg Asp Gln Glu Gly Ala Asp 
                805                 810                 815


Asp Arg Lys Glu Asn Thr Met Ala Glu Asn Glu Ala Gly Lys Glu Glu 
            820                 825                 830


Gln Glu Gly Met Glu Glu Ser Pro Gln Ser Val Gly Arg Gln Glu Lys 
        835                 840                 845


Glu Ala Glu Phe Ser Asp Pro Glu Asn Thr Arg Thr Lys Lys Glu Gln 
    850                 855                 860


Asp Trp Glu Ser Glu Ser Glu Ala Glu Gly Glu Ser Trp Tyr Pro Thr 
865                 870                 875                 880


Asn Met Glu Glu Leu Val Thr Val Asp Glu Val Gly Glu Glu Glu Asp 
                885                 890                 895


Phe Ile Val Glu Pro Asp Ile Pro Glu Leu Glu Glu Ile Val Pro Ile 
            900                 905                 910


Asp Gln Lys Asp Lys Ile Cys Pro Glu Thr Cys Leu Cys Val Thr Thr 
        915                 920                 925


Thr Leu Asp Leu Asp Leu Ala Gln Asp Phe Pro Lys Glu Gly Val Lys 
    930                 935                 940


Ala Val Gly Asn Gly Ala Ala Glu Ile Ser Leu Lys Ser Pro Arg Glu 
945                 950                 955                 960


Leu Pro Ser Ala Ser Thr Ser Cys Pro Ser Asp Met Asp Val Glu Met 
                965                 970                 975


Pro Gly Leu Asn Leu Asp Ala Glu Arg Lys Pro Ala Glu Ser Glu Thr 
            980                 985                 990


Gly Leu Ser Leu Glu Asp Ser Asp Cys Tyr Glu Lys Glu Ala Lys Gly 
        995                 1000                1005


Val Glu Ser Ser Asp Val His Pro Ala Pro Thr Val Gln Gln Met Ser 
    1010                1015                1020


Ser Pro Lys Pro Ala Glu Glu Arg Ala Arg Gln Pro Ser Pro Phe Val 
1025                1030                1035                1040


Asp Asp Cys Lys Thr Arg Gly Thr Pro Glu Asp Gly Ala Cys Glu Gly 
                1045                1050                1055


Ser Pro Leu Glu Glu Lys Ala Ser Pro Pro Ile Glu Thr Asp Leu Gln 
            1060                1065                1070


Asn Gln Ala Cys Gln Glu Val Leu Thr Pro Glu Asn Ser Arg Tyr Val 
        1075                1080                1085


Glu Met Lys Ser Leu Glu Val Arg Ser Pro Glu Tyr Thr Glu Val Glu 
    1090                1095                1100


Leu Lys Gln Pro Leu Ser Leu Pro Ser Trp Glu Pro Glu Asp Val Phe 
1105                1110                1115                1120


Ser Glu Leu Ser Ile Pro Leu Gly Val Glu Phe Val Val Pro Arg Thr 
                1125                1130                1135


Gly Phe Tyr Cys Lys Leu Cys Gly Leu Phe Tyr Thr Ser Glu Glu Thr 
            1140                1145                1150


Ala Lys Met Ser His Cys Arg Ser Ala Val His Tyr Arg Asn Leu Gln 
        1155                1160                1165


Lys Tyr Leu Ser Gln Leu Ala Glu Glu Gly Leu Lys Glu Thr Glu Gly 
    1170                1175                1180


Ala Asp Ser Pro Arg Pro Glu Asp Ser Gly Ile Val Pro Arg Phe Glu 
1185                1190                1195                1200


Arg Lys Lys Leu 



<210>  806
<211>  3591
<212>  DNA
<213>  Homo sapiens

<400>  806
cgaccacccg gcctcggcca ataagcgccg ccctctcgcc cccgtgttac tgggtagaag     60

aaaacaaaaa caaacagagc gagaagggcc agagactctc cgaggcggcg gcagagacag    120

aagagcgggg tcggggccgg ctgaccagga acctgggcga gcagcggcgg gggcccgagg    180

gattctgaag gaagatttcc attaggtaat ttgtttaatc agtgcaagcg aaattaaggg    240

aaaatggatg tagaaaatga gcagatactg aatgtaaacc ctgcagatcc tgataactta    300

agtgactctc tcttttccgg tgatgaagaa aatgctggga ctgaggaaat aaagaatgaa    360

ataaatggaa attggatttc agcatcctcc attaacgaag ctagaattaa tgccaaggca    420

aaaaggcgac taaggaaaaa ctcatcccgg gactctggca gaggcgattc ggtcagcgac    480

agtgggagtg acgcccttag aagtggatta actgtgccaa ccagtccaaa gggaaggttg    540

ctggataggc gatccagatc tgggaaagga aggggactac caaagaaagg tggtgcagga    600

ggcaaaggtg tctggggtac acctggacag gtgtatgatg tggaggaggt ggatgtgaaa    660

gatcctaact atgatgatga ccaggagaac tgtgtttatg aaactgtagt tttgcctttg    720

gatgaaaggg catttgagaa gactttaaca ccaatcatac aggaatattt tgagcatgga    780

gatactaatg aagttgcgga aatgttaaga gatttaaatc ttggtgaaat gaaaagtgga    840

gtaccagtgt tggcagtatc cttagcattg gaggggaagg ctagtcatag agagatgaca    900

tctaagcttc tttctgacct ttgtgggaca gtaatgagca caactgatgt ggaaaaatca    960

tttgataaat tgttgaaaga tctacctgaa ttagcactgg atactcctag agcaccacag   1020

ttggtgggcc agtttattgc tagagctgtt ggagatggaa ttttatgtaa tacctatatt   1080

gatagttaca aaggaactgt agattgtgtg caggctagag ctgctctgga taaggctacc   1140

gtgcttctga gtatgtctaa aggtggaaag cgtaaagata gtgtgtgggg ctctggaggt   1200

gggcagcaat ctgtcaatca ccttgttaaa gagattgata tgctgctgaa agaatattta   1260

ctctctggag acatatctga agctgaacat tgccttaagg aactggaagt acctcatttt   1320

caccatgagc ttgtatatga agctattata atggttttag agtcaactgg agaaagtaca   1380

tttaagatga ttttggattt attaaagtcc ctttggaagt cttctaccat tactgtagac   1440

caaatgaaaa gaggttatga gagaatttac aatgaaattc cggacattaa tctggatgtc   1500

ccacattcat actctgtgct ggagcggttt gtagaagaat gttttcaggc tggaataatt   1560

tccaaacaac tcagagatct ttgtccttca aggggcagaa agcgttttgt aagcgaagga   1620

gatggaggtc gtcttaaacc agagagctac tgaatataag aactcttgca gtcttagatg   1680

ttataaaaat atatatctga attgtaagag ttgttagcac aagttttttt tttttttttt   1740

tttaagcact tgttttgggt acaaggcatt tctgacattt tataaaccta catttaaggg   1800

gaatttttaa aggaaatgtt ttttcttttt tttttgtttt tcgagggggc aaggagggac   1860

agaaaagtaa cctcttctta agtggaatat tctaataagc taccttttgt aagtgccatg   1920

tttattatct aatcattcca agttttgcat tgatgtctga ctgccactcc tttctttcaa   1980

ggacagtgtt ttttgtagta aaatcactgg tttatacaaa gctttattta gggggtaaag   2040

ttaagctgct aaaaccccat gttggctgct gctgttgaga tactgtgctt tgggagtaaa   2100

aaaagaaagt tatttctttg tcttaaagaa tttttaaaaa attagtcatg agacttattc   2160

atctttccag ggaacatact gattggtctt aaaagactag acagttaagt aaaaggtggc   2220

tggaacatct atttttctac aaaactggaa aaatgaacct ggttctagaa gaatgtacac   2280

caaaataaaa catgtgaagc agtattgatt ctttattggg agtacatttt tttaggtctc   2340

ttaaacttta atttcacaca gtaaattttg aatctcataa ggaagcatat ttgaacctag   2400

tcaatttaat cttagtgttc ccttgaaaac tttttttccc tacaaaattt taagtgaaaa   2460

atacaatagt aaattaagat tacactgggg aaaaaaatgc aggtatcact ttactccatt   2520

gttatctgac ctagagctta attaagtttt agaaatatgt aataccttcc atcattccat   2580

catccttaaa ttctgttacc aaataatggc taatgttaca aaaagttata ctccagagac   2640

ccaaagcttg acatttacct aatgtatgag aaaatattac caattaacaa taaagaatga   2700

tcatattttt aacctctttt acatagccta ataactcagc aaggcctcaa cgtctgtgct   2760

aatttaaact gccaaatatt gactgcagca aacaagaatt atattcagaa tttatgaggg   2820

tactgttagg agtatactgc ttacaggttt agatatagtc tgttagaatt aaaaccaagt   2880

ttagtgttca tatttacctc atgggcttta tcaagcccat attacctcag cttatatata   2940

gttaccattt ttaggttttt aattgtttga cacttggatg ataaatgcag tcattttatt   3000

ctcaagtgct taaaattaat gtaattaaaa gcttagctga ctacagaata ggtgagggtt   3060

tcttaaaaat gagatttaag ggctgggcac ggtggctcat gcctgtaatc ccagcacttt   3120

gggaggccga ggtgggcgga tcacttgagg ttgggagttc atgaccagct tgaccaacat   3180

gaagaaaccc tgtctctatt aaaaatacaa aagtagccag gcatggtggc gcatgcgtgt   3240

aatcccagct acttgggagg ctgaggcagg agaattgctt gaacctggga ggcagaggtt   3300

gcagtgagtc gagatggtgc cattgctctc gtttgggcaa caagagtgaa actcttgtct   3360

caaaaaaaaa aaaaaatgag gtttaagaca gttttgtcat tactggtggg atctggtcac   3420

acaagatagc attaaacgtg acatggcaca taaaattggt taaaaaattt tgttttttaa   3480

ttacgtaatg taaaagccca acaaacactt tatgcaagat tggaatgtat cttcaaattc   3540

agatttaata aacatgtaaa gatcctctgt aaaaaaaaaa aaaaaaaaaa a            3591


<210>  807
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  807

Met Asp Val Glu Asn Glu Gln Ile Leu Asn Val Asn Pro Ala Asp Pro 
1               5                   10                  15


Asp Asn Leu Ser Asp Ser Leu Phe Ser Gly Asp Glu Glu Asn Ala Gly 
            20                  25                  30


Thr Glu Glu Ile Lys Asn Glu Ile Asn Gly Asn Trp Ile Ser Ala Ser 
        35                  40                  45


Ser Ile Asn Glu Ala Arg Ile Asn Ala Lys Ala Lys Arg Arg Leu Arg 
    50                  55                  60


Lys Asn Ser Ser Arg Asp Ser Gly Arg Gly Asp Ser Val Ser Asp Ser 
65                  70                  75                  80


Gly Ser Asp Ala Leu Arg Ser Gly Leu Thr Val Pro Thr Ser Pro Lys 
                85                  90                  95


Gly Arg Leu Leu Asp Arg Arg Ser Arg Ser Gly Lys Gly Arg Gly Leu 
            100                 105                 110


Pro Lys Lys Gly Gly Ala Gly Gly Lys Gly Val Trp Gly Thr Pro Gly 
        115                 120                 125


Gln Val Tyr Asp Val Glu Glu Val Asp Val Lys Asp Pro Asn Tyr Asp 
    130                 135                 140


Asp Asp Gln Glu Asn Cys Val Tyr Glu Thr Val Val Leu Pro Leu Asp 
145                 150                 155                 160


Glu Arg Ala Phe Glu Lys Thr Leu Thr Pro Ile Ile Gln Glu Tyr Phe 
                165                 170                 175


Glu His Gly Asp Thr Asn Glu Val Ala Glu Met Leu Arg Asp Leu Asn 
            180                 185                 190


Leu Gly Glu Met Lys Ser Gly Val Pro Val Leu Ala Val Ser Leu Ala 
        195                 200                 205


Leu Glu Gly Lys Ala Ser His Arg Glu Met Thr Ser Lys Leu Leu Ser 
    210                 215                 220


Asp Leu Cys Gly Thr Val Met Ser Thr Thr Asp Val Glu Lys Ser Phe 
225                 230                 235                 240


Asp Lys Leu Leu Lys Asp Leu Pro Glu Leu Ala Leu Asp Thr Pro Arg 
                245                 250                 255


Ala Pro Gln Leu Val Gly Gln Phe Ile Ala Arg Ala Val Gly Asp Gly 
            260                 265                 270


Ile Leu Cys Asn Thr Tyr Ile Asp Ser Tyr Lys Gly Thr Val Asp Cys 
        275                 280                 285


Val Gln Ala Arg Ala Ala Leu Asp Lys Ala Thr Val Leu Leu Ser Met 
    290                 295                 300


Ser Lys Gly Gly Lys Arg Lys Asp Ser Val Trp Gly Ser Gly Gly Gly 
305                 310                 315                 320


Gln Gln Ser Val Asn His Leu Val Lys Glu Ile Asp Met Leu Leu Lys 
                325                 330                 335


Glu Tyr Leu Leu Ser Gly Asp Ile Ser Glu Ala Glu His Cys Leu Lys 
            340                 345                 350


Glu Leu Glu Val Pro His Phe His His Glu Leu Val Tyr Glu Ala Ile 
        355                 360                 365


Ile Met Val Leu Glu Ser Thr Gly Glu Ser Thr Phe Lys Met Ile Leu 
    370                 375                 380


Asp Leu Leu Lys Ser Leu Trp Lys Ser Ser Thr Ile Thr Val Asp Gln 
385                 390                 395                 400


Met Lys Arg Gly Tyr Glu Arg Ile Tyr Asn Glu Ile Pro Asp Ile Asn 
                405                 410                 415


Leu Asp Val Pro His Ser Tyr Ser Val Leu Glu Arg Phe Val Glu Glu 
            420                 425                 430


Cys Phe Gln Ala Gly Ile Ile Ser Lys Gln Leu Arg Asp Leu Cys Pro 
        435                 440                 445


Ser Arg Gly Arg Lys Arg Phe Val Ser Glu Gly Asp Gly Gly Arg Leu 
    450                 455                 460


Lys Pro Glu Ser Tyr 
465


<210>  808
<211>  3675
<212>  DNA
<213>  Homo sapiens

<400>  808
cgaccacccg gcctcggcca ataagcgccg ccctctcgcc cccgtgttac tgggtagaag     60

aaaacaaaaa caaacagagc gagaagggcc agagactctc cgaggcggcg gcagagacag    120

aagagcgggg tcggggccgg ctgaccagga acctgggcga gcagcggcgg gggcccgagg    180

gattctgaag gaagatttcc attaggtaat ttgtttaatc agtgcaagcg aaattaaggg    240

aaaatggatg tagaaaatga gcagatactg aatgtaaacc ctgcagggta ttttccctaa    300

ttctccatgg tgcttcaata gcatgttatt atcataaaaa tgaacagttt tgtggaatag    360

atgaccaaat atcctgataa cttaagtgac tctctctttt ccggtgatga agaaaatgct    420

gggactgagg aaataaagaa tgaaataaat ggaaattgga tttcagcatc ctccattaac    480

gaagctagaa ttaatgccaa ggcaaaaagg cgactaagga aaaactcatc ccgggactct    540

ggcagaggcg attcggtcag cgacagtggg agtgacgccc ttagaagtgg attaactgtg    600

ccaaccagtc caaagggaag gttgctggat aggcgatcca gatctgggaa aggaagggga    660

ctaccaaaga aaggtggtgc aggaggcaaa ggtgtctggg gtacacctgg acaggtgtat    720

gatgtggagg aggtggatgt gaaagatcct aactatgatg atgaccagga gaactgtgtt    780

tatgaaactg tagttttgcc tttggatgaa agggcatttg agaagacttt aacaccaatc    840

atacaggaat attttgagca tggagatact aatgaagttg cggaaatgtt aagagattta    900

aatcttggtg aaatgaaaag tggagtacca gtgttggcag tatccttagc attggagggg    960

aaggctagtc atagagagat gacatctaag cttctttctg acctttgtgg gacagtaatg   1020

agcacaactg atgtggaaaa atcatttgat aaattgttga aagatctacc tgaattagca   1080

ctggatactc ctagagcacc acagttggtg ggccagttta ttgctagagc tgttggagat   1140

ggaattttat gtaataccta tattgatagt tacaaaggaa ctgtagattg tgtgcaggct   1200

agagctgctc tggataaggc taccgtgctt ctgagtatgt ctaaaggtgg aaagcgtaaa   1260

gatagtgtgt ggggctctgg aggtgggcag caatctgtca atcaccttgt taaagagatt   1320

gatatgctgc tgaaagaata tttactctct ggagacatat ctgaagctga acattgcctt   1380

aaggaactgg aagtacctca ttttcaccat gagcttgtat atgaagctat tataatggtt   1440

ttagagtcaa ctggagaaag tacatttaag atgattttgg atttattaaa gtccctttgg   1500

aagtcttcta ccattactgt agaccaaatg aaaagaggtt atgagagaat ttacaatgaa   1560

attccggaca ttaatctgga tgtcccacat tcatactctg tgctggagcg gtttgtagaa   1620

gaatgttttc aggctggaat aatttccaaa caactcagag atctttgtcc ttcaaggggc   1680

agaaagcgtt ttgtaagcga aggagatgga ggtcgtctta aaccagagag ctactgaata   1740

taagaactct tgcagtctta gatgttataa aaatatatat ctgaattgta agagttgtta   1800

gcacaagttt tttttttttt tttttttaag cacttgtttt gggtacaagg catttctgac   1860

attttataaa cctacattta aggggaattt ttaaaggaaa tgttttttct tttttttttg   1920

tttttcgagg gggcaaggag ggacagaaaa gtaacctctt cttaagtgga atattctaat   1980

aagctacctt ttgtaagtgc catgtttatt atctaatcat tccaagtttt gcattgatgt   2040

ctgactgcca ctcctttctt tcaaggacag tgttttttgt agtaaaatca ctggtttata   2100

caaagcttta tttagggggt aaagttaagc tgctaaaacc ccatgttggc tgctgctgtt   2160

gagatactgt gctttgggag taaaaaaaga aagttatttc tttgtcttaa agaattttta   2220

aaaaattagt catgagactt attcatcttt ccagggaaca tactgattgg tcttaaaaga   2280

ctagacagtt aagtaaaagg tggctggaac atctattttt ctacaaaact ggaaaaatga   2340

acctggttct agaagaatgt acaccaaaat aaaacatgtg aagcagtatt gattctttat   2400

tgggagtaca tttttttagg tctcttaaac tttaatttca cacagtaaat tttgaatctc   2460

ataaggaagc atatttgaac ctagtcaatt taatcttagt gttcccttga aaactttttt   2520

tccctacaaa attttaagtg aaaaatacaa tagtaaatta agattacact ggggaaaaaa   2580

atgcaggtat cactttactc cattgttatc tgacctagag cttaattaag ttttagaaat   2640

atgtaatacc ttccatcatt ccatcatcct taaattctgt taccaaataa tggctaatgt   2700

tacaaaaagt tatactccag agacccaaag cttgacattt acctaatgta tgagaaaata   2760

ttaccaatta acaataaaga atgatcatat ttttaacctc ttttacatag cctaataact   2820

cagcaaggcc tcaacgtctg tgctaattta aactgccaaa tattgactgc agcaaacaag   2880

aattatattc agaatttatg agggtactgt taggagtata ctgcttacag gtttagatat   2940

agtctgttag aattaaaacc aagtttagtg ttcatattta cctcatgggc tttatcaagc   3000

ccatattacc tcagcttata tatagttacc atttttaggt ttttaattgt ttgacacttg   3060

gatgataaat gcagtcattt tattctcaag tgcttaaaat taatgtaatt aaaagcttag   3120

ctgactacag aataggtgag ggtttcttaa aaatgagatt taagggctgg gcacggtggc   3180

tcatgcctgt aatcccagca ctttgggagg ccgaggtggg cggatcactt gaggttggga   3240

gttcatgacc agcttgacca acatgaagaa accctgtctc tattaaaaat acaaaagtag   3300

ccaggcatgg tggcgcatgc gtgtaatccc agctacttgg gaggctgagg caggagaatt   3360

gcttgaacct gggaggcaga ggttgcagtg agtcgagatg gtgccattgc tctcgtttgg   3420

gcaacaagag tgaaactctt gtctcaaaaa aaaaaaaaaa tgaggtttaa gacagttttg   3480

tcattactgg tgggatctgg tcacacaaga tagcattaaa cgtgacatgg cacataaaat   3540

tggttaaaaa attttgtttt ttaattacgt aatgtaaaag cccaacaaac actttatgca   3600

agattggaat gtatcttcaa attcagattt aataaacatg taaagatcct ctgtaaaaaa   3660

aaaaaaaaaa aaaaa                                                    3675


<210>  809
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  809

Met Thr Lys Tyr Pro Asp Asn Leu Ser Asp Ser Leu Phe Ser Gly Asp 
1               5                   10                  15


Glu Glu Asn Ala Gly Thr Glu Glu Ile Lys Asn Glu Ile Asn Gly Asn 
            20                  25                  30


Trp Ile Ser Ala Ser Ser Ile Asn Glu Ala Arg Ile Asn Ala Lys Ala 
        35                  40                  45


Lys Arg Arg Leu Arg Lys Asn Ser Ser Arg Asp Ser Gly Arg Gly Asp 
    50                  55                  60


Ser Val Ser Asp Ser Gly Ser Asp Ala Leu Arg Ser Gly Leu Thr Val 
65                  70                  75                  80


Pro Thr Ser Pro Lys Gly Arg Leu Leu Asp Arg Arg Ser Arg Ser Gly 
                85                  90                  95


Lys Gly Arg Gly Leu Pro Lys Lys Gly Gly Ala Gly Gly Lys Gly Val 
            100                 105                 110


Trp Gly Thr Pro Gly Gln Val Tyr Asp Val Glu Glu Val Asp Val Lys 
        115                 120                 125


Asp Pro Asn Tyr Asp Asp Asp Gln Glu Asn Cys Val Tyr Glu Thr Val 
    130                 135                 140


Val Leu Pro Leu Asp Glu Arg Ala Phe Glu Lys Thr Leu Thr Pro Ile 
145                 150                 155                 160


Ile Gln Glu Tyr Phe Glu His Gly Asp Thr Asn Glu Val Ala Glu Met 
                165                 170                 175


Leu Arg Asp Leu Asn Leu Gly Glu Met Lys Ser Gly Val Pro Val Leu 
            180                 185                 190


Ala Val Ser Leu Ala Leu Glu Gly Lys Ala Ser His Arg Glu Met Thr 
        195                 200                 205


Ser Lys Leu Leu Ser Asp Leu Cys Gly Thr Val Met Ser Thr Thr Asp 
    210                 215                 220


Val Glu Lys Ser Phe Asp Lys Leu Leu Lys Asp Leu Pro Glu Leu Ala 
225                 230                 235                 240


Leu Asp Thr Pro Arg Ala Pro Gln Leu Val Gly Gln Phe Ile Ala Arg 
                245                 250                 255


Ala Val Gly Asp Gly Ile Leu Cys Asn Thr Tyr Ile Asp Ser Tyr Lys 
            260                 265                 270


Gly Thr Val Asp Cys Val Gln Ala Arg Ala Ala Leu Asp Lys Ala Thr 
        275                 280                 285


Val Leu Leu Ser Met Ser Lys Gly Gly Lys Arg Lys Asp Ser Val Trp 
    290                 295                 300


Gly Ser Gly Gly Gly Gln Gln Ser Val Asn His Leu Val Lys Glu Ile 
305                 310                 315                 320


Asp Met Leu Leu Lys Glu Tyr Leu Leu Ser Gly Asp Ile Ser Glu Ala 
                325                 330                 335


Glu His Cys Leu Lys Glu Leu Glu Val Pro His Phe His His Glu Leu 
            340                 345                 350


Val Tyr Glu Ala Ile Ile Met Val Leu Glu Ser Thr Gly Glu Ser Thr 
        355                 360                 365


Phe Lys Met Ile Leu Asp Leu Leu Lys Ser Leu Trp Lys Ser Ser Thr 
    370                 375                 380


Ile Thr Val Asp Gln Met Lys Arg Gly Tyr Glu Arg Ile Tyr Asn Glu 
385                 390                 395                 400


Ile Pro Asp Ile Asn Leu Asp Val Pro His Ser Tyr Ser Val Leu Glu 
                405                 410                 415


Arg Phe Val Glu Glu Cys Phe Gln Ala Gly Ile Ile Ser Lys Gln Leu 
            420                 425                 430


Arg Asp Leu Cys Pro Ser Arg Gly Arg Lys Arg Phe Val Ser Glu Gly 
        435                 440                 445


Asp Gly Gly Arg Leu Lys Pro Glu Ser Tyr 
    450                 455


<210>  810
<211>  587
<212>  DNA
<213>  Homo sapiens

<400>  810
ctttcccaag gggcagccga agatggcaga ggtgcaggtc ctggtgcttg atggtcgagg     60

ccatctcctg ggccgcctgg cgaccatcgt ggctaaacag gtactgctgg gccggaaggt    120

ggtggtcgta cgctgcaaag gcatcaacat ttctggcaat ttctacagaa acaagttgaa    180

gtacttggct ttcctccgca agcggatgaa caccaaccct ttccgacgcc cctaccactt    240

ccgggccccc agccccatct tctggctgac tgtgcgaagt atgctgcccc acaagaccaa    300

gcgaggccag gccgctctgg accgcctcaa ggttgtgcgt ctgaagccta caagaaagtt    360

tgcctatctg gggcacctgg ctcacgaggt tggctggaag taccacgcag tgacagccac    420

cctggaggag aagaggaaag agaaagccaa aatccactac cggaagaaga aagagctcat    480

aagcctacgg aaacaggcca agaggaacat ggagaagaaa actgacaaat acacagaggt    540

cctcaagacc cacggactcc tggtctgagc ccaataaaga ctgttaa                  587


<210>  811
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  811

Met Ala Glu Val Gln Val Leu Val Leu Asp Gly Arg Gly His Leu Leu 
1               5                   10                  15


Gly Arg Leu Ala Thr Ile Val Ala Lys Gln Val Leu Leu Gly Arg Lys 
            20                  25                  30


Val Val Val Val Arg Cys Lys Gly Ile Asn Ile Ser Gly Asn Phe Tyr 
        35                  40                  45


Arg Asn Lys Leu Lys Tyr Leu Ala Phe Leu Arg Lys Arg Met Asn Thr 
    50                  55                  60


Asn Pro Phe Arg Arg Pro Tyr His Phe Arg Ala Pro Ser Pro Ile Phe 
65                  70                  75                  80


Trp Leu Thr Val Arg Ser Met Leu Pro His Lys Thr Lys Arg Gly Gln 
                85                  90                  95


Ala Ala Leu Asp Arg Leu Lys Val Val Arg Leu Lys Pro Thr Arg Lys 
            100                 105                 110


Phe Ala Tyr Leu Gly His Leu Ala His Glu Val Gly Trp Lys Tyr His 
        115                 120                 125


Ala Val Thr Ala Thr Leu Glu Glu Lys Arg Lys Glu Lys Ala Lys Ile 
    130                 135                 140


His Tyr Arg Lys Lys Lys Glu Leu Ile Ser Leu Arg Lys Gln Ala Lys 
145                 150                 155                 160


Arg Asn Met Glu Lys Lys Thr Asp Lys Tyr Thr Glu Val Leu Lys Thr 
                165                 170                 175


His Gly Leu Leu Val 
            180


<210>  812
<211>  3823
<212>  DNA
<213>  Homo sapiens

<400>  812
ctattttacc agttggaatg aatgatcaga aatgggcata gtgcttttag atccaacatg     60

taacagatgg atgttactcc atgctgatta cttcttcaag ccagtacttt tttgattgtg    120

taggatcttt gtctcttcat ctttgaattc aattactgga aaataaaagg agttcatgta    180

gtttttgtcc aggcttgagt caccatgagt agtagtttag gaaaagaaaa agactctaaa    240

gaaaaagatc ccaaagtacc atcagccaag gaaagagaaa aggaggcaaa agcctctgga    300

ggttttggga aagagagcaa agaaaaagaa cctaagacca aagggaaaga tgccaaagat    360

ggaaagaagg actccagtgc tgcccaacca ggggtggcat tttcagttga caatacgatc    420

aaacggccaa acccagcacc tgggactaga aaaaaatcca gcaatgcaga ggtgattaaa    480

gagctcaaca aatgccggga agagaattca atgcgtttgg acttatccaa gagatctata    540

cacatattgc catcatcaat caaagagttg actcaattaa cagaacttta tttatacagt    600

aacaaattgc agtccctccc agcagaggtg ggatgtttag taaatctcat gacactggct    660

ctaagtgaaa attcacttac cagtttgcct gactctcttg ataacttgaa gaagctgcgg    720

atgcttgatt tacggcataa taaactgaga gaaattcctt cagtggtgta taggctggat    780

tctctcacca ctctttacct tcgctttaat cgtataacta ctgtggaaaa ggacatcaaa    840

aacttgtcaa aactcagcat gcttagcatt cgagagaaca aaattaaaca actacctgct    900

gaaattggtg aattatgtaa cctcattacg ctggatgtag ctcacaatca acttgaacac    960

cttccaaagg agattggaaa ctgtacacag ataaccaacc ttgacttgca gcacaatgaa   1020

ctgctagacc tcccagatac tataggaaac ctgtccagtt taagtcgtct tggtctgaga   1080

tataacagac tgtcagcaat acccagatca ttagcaaaat gcagtgcact tgaagaatta   1140

aatttagaga acaataacat ttctacttta ccagagagtc ttttatcaag tcttgtgaaa   1200

ctgaatagtt tgaccttagc tagaaattgc ttccagttgt atccagtggg tggtccatct   1260

cagttttcta ccatctattc cctcaacatg gaacacaatc gaatcaacaa aattccattt   1320

ggaattttct ccagagcaaa agtattaagt aagctgaata tgaaggacaa tcagttaaca   1380

tcacttccct tggattttgg aacttggacc agtatggtag aattgaattt agccactaat   1440

cagctcacaa agatccctga ggatgtgtct ggtctcgttt ctcttgaggt tcttatctta   1500

tcaaacaatc ttctaaagaa gcttccccat ggtcttggaa accttaggaa gttaagagag   1560

ttggatctag aagagaacaa attggaatcc ttgccaaatg aaattgcata tcttaaggat   1620

ttacagaaat tagtcttgac aaacaaccag ttgaccactc ttcccagagg cattggtcac   1680

cttactaatc tcacacatct gggccttgga gagaacctac ttactcacct tcctgaagaa   1740

attggtacac tggagaacct agaagaactg tatttgaatg acaaccccaa cctgcatagc   1800

cttccctttg agctggcact ctgcagcaag ctttcaatca tgagtattga gaactgtcca   1860

ctcagtcacc ttccacctca gattgttgct ggggggcctt ctttcatcat tcagttctta   1920

aagatgcagg gtccatatcg tgccatggtc tgatataaat ctgctggtcc cacacactgt   1980

tcaaaaatag actgccatta atgtttctta tctatatctg tatctattta tgtagatatt   2040

ggtatatggc agatttataa aaattgcatt atgtgtttct gctaatagag gaatcatagc   2100

catttagaat tttttttaaa ttctgtacaa aaggcttata taagttttct ttgctgaatt   2160

tgatggatgt ttttctgttg tgtaatctga tatgccagtt tgcttaaaac atttgccaac   2220

acattatgaa gttattaaat ttaagggaca gaggtagtat agttagatat actttctctt   2280

aggaaaaata atgggcaaaa atttttgttg caacttttca tatatatttt ccccttacca   2340

attgttttat ccttatagta ttgtaggccc tgaaagtaga atttttcttt aacttatttt   2400

gagatttgag atttaaattt tatgtattgt ttacagtcag agtaaatcac tggatttctt   2460

ttgtttgttt tgatttgctc tgttttattc agtcaaatct agagtttgaa tcctctgcta   2520

aagaatttgc atccactggt gtaaacagtg aaaggtattt gcttgttgaa aaaaaaaact   2580

ggcaaagtga aaagatacag tcaaaaatct agaatttctt taattttgct tctctgacga   2640

gttgtgaagc aaaatacctg aagtgagtct ttgggtaggg gaagggtatt gagacctttt   2700

ctagtatgaa tattttttaa gtttggggga agagaaactt gcagtgaaaa ggagtttttt   2760

cattcctgaa agttgcagat ccacaaaact aacaggataa ttgggcaaat aaattacata   2820

taaacacaca caatctatat atgtatatac aatgctatat agatatgtat ttattatatc   2880

ataaactaca gtaggtaact ttaaggattt cttcctatcc ttgtacaatg acatgaatgt   2940

ctttctttga aaactgcaat gtatgtatgt ttcaaggtta tttaacagtg tactatggtt   3000

ttatatcttg acttgccttg tacatctttc aattctggaa tatctgtgtc taagcacaat   3060

atcttcacac tgtgctgtat tgctgctgaa ctaaatgcac ttttccccac atatggggca   3120

ctggcttcaa acaattcagt tcagtatcat tacttttaat ctcatctttc ctttcttggt   3180

agttgttaat acagttatgg aaaagaggca cattgcatag aagccattgg ggagttcagt   3240

ggaagttctg taagatgtgc atgtactatt tgatgcgttt tctttgcttc actgctttta   3300

atacttagca gtattgttgg tctaagtcaa tttgattatt gaggagtctc agagcaaggt   3360

gcgttctaga tgtcatccta aaaaacactt catatataat taatcactat tttgtataat   3420

tacatattgc tgcttgtgtg tttttttttt ttttccattt agttgggcgt tgtgttttac   3480

acaaaaccat ttttgaatta aggctatgat attaagatag aaatttggac tgttgttctg   3540

cttttcctgg cactcaaatt catgactagt tttgaggtca aacctatgtt cgtaatgaga   3600

gattttataa ggatcaacta agaaatggaa ggcaggtgaa gatataaaac cctagaatgc   3660

ttaaatgtgc tgtaaaacta ttgtagatgt cactggattt taccaagtaa tatcctttct   3720

tttttttttc cccccatctg ctgtggcttt tcagttaaaa ttttgtttat aaaaggaatt   3780

tgtttattac agctctacct aaaaaaaaaa aaaaaaaaaa aaa                     3823


<210>  813
<211>  582
<212>  PRT
<213>  Homo sapiens

<400>  813

Met Ser Ser Ser Leu Gly Lys Glu Lys Asp Ser Lys Glu Lys Asp Pro 
1               5                   10                  15


Lys Val Pro Ser Ala Lys Glu Arg Glu Lys Glu Ala Lys Ala Ser Gly 
            20                  25                  30


Gly Phe Gly Lys Glu Ser Lys Glu Lys Glu Pro Lys Thr Lys Gly Lys 
        35                  40                  45


Asp Ala Lys Asp Gly Lys Lys Asp Ser Ser Ala Ala Gln Pro Gly Val 
    50                  55                  60


Ala Phe Ser Val Asp Asn Thr Ile Lys Arg Pro Asn Pro Ala Pro Gly 
65                  70                  75                  80


Thr Arg Lys Lys Ser Ser Asn Ala Glu Val Ile Lys Glu Leu Asn Lys 
                85                  90                  95


Cys Arg Glu Glu Asn Ser Met Arg Leu Asp Leu Ser Lys Arg Ser Ile 
            100                 105                 110


His Ile Leu Pro Ser Ser Ile Lys Glu Leu Thr Gln Leu Thr Glu Leu 
        115                 120                 125


Tyr Leu Tyr Ser Asn Lys Leu Gln Ser Leu Pro Ala Glu Val Gly Cys 
    130                 135                 140


Leu Val Asn Leu Met Thr Leu Ala Leu Ser Glu Asn Ser Leu Thr Ser 
145                 150                 155                 160


Leu Pro Asp Ser Leu Asp Asn Leu Lys Lys Leu Arg Met Leu Asp Leu 
                165                 170                 175


Arg His Asn Lys Leu Arg Glu Ile Pro Ser Val Val Tyr Arg Leu Asp 
            180                 185                 190


Ser Leu Thr Thr Leu Tyr Leu Arg Phe Asn Arg Ile Thr Thr Val Glu 
        195                 200                 205


Lys Asp Ile Lys Asn Leu Ser Lys Leu Ser Met Leu Ser Ile Arg Glu 
    210                 215                 220


Asn Lys Ile Lys Gln Leu Pro Ala Glu Ile Gly Glu Leu Cys Asn Leu 
225                 230                 235                 240


Ile Thr Leu Asp Val Ala His Asn Gln Leu Glu His Leu Pro Lys Glu 
                245                 250                 255


Ile Gly Asn Cys Thr Gln Ile Thr Asn Leu Asp Leu Gln His Asn Glu 
            260                 265                 270


Leu Leu Asp Leu Pro Asp Thr Ile Gly Asn Leu Ser Ser Leu Ser Arg 
        275                 280                 285


Leu Gly Leu Arg Tyr Asn Arg Leu Ser Ala Ile Pro Arg Ser Leu Ala 
    290                 295                 300


Lys Cys Ser Ala Leu Glu Glu Leu Asn Leu Glu Asn Asn Asn Ile Ser 
305                 310                 315                 320


Thr Leu Pro Glu Ser Leu Leu Ser Ser Leu Val Lys Leu Asn Ser Leu 
                325                 330                 335


Thr Leu Ala Arg Asn Cys Phe Gln Leu Tyr Pro Val Gly Gly Pro Ser 
            340                 345                 350


Gln Phe Ser Thr Ile Tyr Ser Leu Asn Met Glu His Asn Arg Ile Asn 
        355                 360                 365


Lys Ile Pro Phe Gly Ile Phe Ser Arg Ala Lys Val Leu Ser Lys Leu 
    370                 375                 380


Asn Met Lys Asp Asn Gln Leu Thr Ser Leu Pro Leu Asp Phe Gly Thr 
385                 390                 395                 400


Trp Thr Ser Met Val Glu Leu Asn Leu Ala Thr Asn Gln Leu Thr Lys 
                405                 410                 415


Ile Pro Glu Asp Val Ser Gly Leu Val Ser Leu Glu Val Leu Ile Leu 
            420                 425                 430


Ser Asn Asn Leu Leu Lys Lys Leu Pro His Gly Leu Gly Asn Leu Arg 
        435                 440                 445


Lys Leu Arg Glu Leu Asp Leu Glu Glu Asn Lys Leu Glu Ser Leu Pro 
    450                 455                 460


Asn Glu Ile Ala Tyr Leu Lys Asp Leu Gln Lys Leu Val Leu Thr Asn 
465                 470                 475                 480


Asn Gln Leu Thr Thr Leu Pro Arg Gly Ile Gly His Leu Thr Asn Leu 
                485                 490                 495


Thr His Leu Gly Leu Gly Glu Asn Leu Leu Thr His Leu Pro Glu Glu 
            500                 505                 510


Ile Gly Thr Leu Glu Asn Leu Glu Glu Leu Tyr Leu Asn Asp Asn Pro 
        515                 520                 525


Asn Leu His Ser Leu Pro Phe Glu Leu Ala Leu Cys Ser Lys Leu Ser 
    530                 535                 540


Ile Met Ser Ile Glu Asn Cys Pro Leu Ser His Leu Pro Pro Gln Ile 
545                 550                 555                 560


Val Ala Gly Gly Pro Ser Phe Ile Ile Gln Phe Leu Lys Met Gln Gly 
                565                 570                 575


Pro Tyr Arg Ala Met Val 
            580


<210>  814
<211>  3653
<212>  DNA
<213>  Homo sapiens

<400>  814
gcgctcggcg cccaccaggc ggacgcccag gagaacccct gcctccgtcg cggctcctgg     60

agagctgatc gttcacctgc cccggcccgc ctgaggacgg gggtgccttc atgcggcccc    120

cacactcctc accccgccgc cgccgccgtc cccgagctcc gcacagtgcg ccccagcccc    180

agcagggcgc acaactttgg aagtctcgcg gcgctccgag aggcggcaga gtccgcgccc    240

cagccccggg ccgggccggg ccagaaccgc agcgtctggg ggaagccaga gagtcggtaa    300

tcgcttcggg gatgtaaggc gacagacata ggacccccga gctcgcatca gcacccttcg    360

gctgcctccc ggggtggggg cgggccccgc acacggtaag acctcttgct ttcgctcagg    420

ctcaagattc aagatacaga tattgatatg tatatatata tttaatttcc tgtcatcctt    480

ccaagttatc aggccaccga tgatttttgt tctcccttct tgaagaataa atctctcttt    540

acccatcggc tctccctact ctctcccgcc gcttagaaat aaaacttggc tgtattagga    600

gctcggagca agaaggcgcc caccgagagc gtctgaagcg cgagccaggc gcagttcgcg    660

ggacccgggc catgggccgc tagcggtcct ccagttcggg cccggcctcc ctgcggcccc    720

ctccctatgt gagccgcagc caggcgagcg gggcgccgga ggaagaggag gacccacggg    780

cgccgggccg gaaggcagct ggcagcaggc ccaggccagc gggcgcccgc gttcatgttc    840

cgccaggagc agccgttggc cgagggcagc tttgcgccca tgggctccct gcagccggac    900

gcgggcaacg cgagctggaa cgggaccgag gcgccggggg gcggcgcccg ggccacccct    960

tactccctgc aggtgacgct gacgctggtg tgcctggccg gcctgctcat gctgctcacc   1020

gtgttcggca acgtgctcgt catcatcgcc gtgttcacga gccgcgcgct caaggcgccc   1080

caaaacctct tcctggtgtc tctggcctcg gccgacatcc tggtggccac gctcgtcatc   1140

cctttctcgc tggccaacga ggtcatgggc tactggtact tcggcaaggc ttggtgcgag   1200

atctacctgg cgctcgacgt gctcttctgc acgtcgtcca tcgtgcacct gtgcgccatc   1260

agcctggacc gctactggtc catcacacag gccatcgagt acaacctgaa gcgcacgccg   1320

cgccgcatca aggccatcat catcaccgtg tgggtcatct cggccgtcat ctccttcccg   1380

ccgctcatct ccatcgagaa gaagggcggc ggcggcggcc cgcagccggc cgagccgcgc   1440

tgcgagatca acgaccagaa gtggtacgtc atctcgtcgt gcatcggctc cttcttcgct   1500

ccctgcctca tcatgatcct ggtctacgtg cgcatctacc agatcgccaa gcgtcgcacc   1560

cgcgtgccac ccagccgccg gggtccggac gccgtcgccg cgccgccggg gggcaccgag   1620

cgcaggccca acggtctggg ccccgagcgc agcgcgggcc cggggggcgc agaggccgaa   1680

ccgctgccca cccagctcaa cggcgcccct ggcgagcccg cgccggccgg gccgcgcgac   1740

accgacgcgc tggacctgga ggagagctcg tcttccgacc acgccgagcg gcctccaggg   1800

ccccgcagac ccgagcgcgg tccccggggc aaaggcaagg cccgagcgag ccaggtgaag   1860

ccgggcgaca gcctgccgcg gcgcgggccg ggggcgacgg ggatcgggac gccggctgca   1920

gggccggggg aggagcgcgt cggggctgcc aaggcgtcgc gctggcgcgg gcggcagaac   1980

cgcgagaagc gcttcacgtt cgtgctggcc gtggtcatcg gagtgttcgt ggtgtgctgg   2040

ttccccttct tcttcaccta cacgctcacg gccgtcgggt gctccgtgcc acgcacgctc   2100

ttcaaattct tcttctggtt cggctactgc aacagctcgt tgaacccggt catctacacc   2160

atcttcaacc acgatttccg ccgcgccttc aagaagatcc tctgtcgggg ggacaggaag   2220

cggatcgtgt gaggtttccg ctggcgcccg cgtagactca cgctgactgc aggcagcggg   2280

gggcatcgag gggtgcttag ccccagggca ctcagaaacc cgggcgctgc ctgctctgcg   2340

tttcctcgtc tggggtggct ctgcagcctc ctgcgggcgg gcgtctgctg ctcctacaag   2400

ggaagcttct tgctgccagg cccacacatc cccagttgtt ggtttggcca ctcttgacct   2460

ggagccatct tcctagtggg ccacccctaa tcactattgc ttcctaaagg tattttcacc   2520

ctcttcgcct ggtacagccc tcacagctct tcagagcaag cactggacta caagggcatg   2580

gctcacaaaa ggttaatgga tgggggttac ctagccctgg ctaattcccc ttccattccc   2640

aactctctct ctctttttga agaaaaatgc taagggcagc cctgcctgcc ctccccatcc   2700

cccgctgtaa atatacacta tttttgatag cacacatggg gcccccatat ctcttggcct   2760

tggttttgat gttgaaatcc tggccttggg agagatgcct tccaggcaga cacagctgtc   2820

tggttcaggc caagcccctt tgcaatgcaa gccctttctg gtgttatgaa gtccctctat   2880

gtcgtcgttt tcaccagcaa ctggtgactg tcccttcgac acggacctgc tttgagattt   2940

cctgacaggg aaaagatttc tgtccatttt tttcctgtgc ctaacagcat aattgccttt   3000

tcctatgtaa atattatgat ggtggatcaa gacataagta aatgagcctt tctgcctcac   3060

atcagccctg tgtataaagc cattattctc tgatgcactg tttgccccag taactcactt   3120

taaaacctct ctttccagtg ttccctctct ccctccaggg ccactgcttg aagaagaata   3180

tgtatgtttc tatcttgtat gtctgtgtgc ccctcctgcc ccgaaagtgc tgactatggg   3240

gaaatctttt agctgctgtt tttagactcc aaggagtgga aattatgtgg aagaagcaaa   3300

cctgatacaa tttgcccaag gtaaacagtt tgaaaagaca aatgggcctg ccaaactgta   3360

cagtttcttc cccaagagct gttaggtatc aaaatgttgt cctttccccc ctccgtgctt   3420

ttctggttga gatcatgtca ttgatgaact gccaaagtca ggggaggagg gcagagactt   3480

tgtgtttaca tctgcatttc tacatgtttt agacagagac aatttaaggc ctgcactctt   3540

atttcactaa agaaaaacta atgtcagcac atgttgctaa tgacagtgga ttttttttta   3600

aataaaaaag tttacagatc aaatgtgaaa taaatatgaa tggagtggtc aaa          3653


<210>  815
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  815

Met Gly Ser Leu Gln Pro Asp Ala Gly Asn Ala Ser Trp Asn Gly Thr 
1               5                   10                  15


Glu Ala Pro Gly Gly Gly Ala Arg Ala Thr Pro Tyr Ser Leu Gln Val 
            20                  25                  30


Thr Leu Thr Leu Val Cys Leu Ala Gly Leu Leu Met Leu Leu Thr Val 
        35                  40                  45


Phe Gly Asn Val Leu Val Ile Ile Ala Val Phe Thr Ser Arg Ala Leu 
    50                  55                  60


Lys Ala Pro Gln Asn Leu Phe Leu Val Ser Leu Ala Ser Ala Asp Ile 
65                  70                  75                  80


Leu Val Ala Thr Leu Val Ile Pro Phe Ser Leu Ala Asn Glu Val Met 
                85                  90                  95


Gly Tyr Trp Tyr Phe Gly Lys Ala Trp Cys Glu Ile Tyr Leu Ala Leu 
            100                 105                 110


Asp Val Leu Phe Cys Thr Ser Ser Ile Val His Leu Cys Ala Ile Ser 
        115                 120                 125


Leu Asp Arg Tyr Trp Ser Ile Thr Gln Ala Ile Glu Tyr Asn Leu Lys 
    130                 135                 140


Arg Thr Pro Arg Arg Ile Lys Ala Ile Ile Ile Thr Val Trp Val Ile 
145                 150                 155                 160


Ser Ala Val Ile Ser Phe Pro Pro Leu Ile Ser Ile Glu Lys Lys Gly 
                165                 170                 175


Gly Gly Gly Gly Pro Gln Pro Ala Glu Pro Arg Cys Glu Ile Asn Asp 
            180                 185                 190


Gln Lys Trp Tyr Val Ile Ser Ser Cys Ile Gly Ser Phe Phe Ala Pro 
        195                 200                 205


Cys Leu Ile Met Ile Leu Val Tyr Val Arg Ile Tyr Gln Ile Ala Lys 
    210                 215                 220


Arg Arg Thr Arg Val Pro Pro Ser Arg Arg Gly Pro Asp Ala Val Ala 
225                 230                 235                 240


Ala Pro Pro Gly Gly Thr Glu Arg Arg Pro Asn Gly Leu Gly Pro Glu 
                245                 250                 255


Arg Ser Ala Gly Pro Gly Gly Ala Glu Ala Glu Pro Leu Pro Thr Gln 
            260                 265                 270


Leu Asn Gly Ala Pro Gly Glu Pro Ala Pro Ala Gly Pro Arg Asp Thr 
        275                 280                 285


Asp Ala Leu Asp Leu Glu Glu Ser Ser Ser Ser Asp His Ala Glu Arg 
    290                 295                 300


Pro Pro Gly Pro Arg Arg Pro Glu Arg Gly Pro Arg Gly Lys Gly Lys 
305                 310                 315                 320


Ala Arg Ala Ser Gln Val Lys Pro Gly Asp Ser Leu Pro Arg Arg Gly 
                325                 330                 335


Pro Gly Ala Thr Gly Ile Gly Thr Pro Ala Ala Gly Pro Gly Glu Glu 
            340                 345                 350


Arg Val Gly Ala Ala Lys Ala Ser Arg Trp Arg Gly Arg Gln Asn Arg 
        355                 360                 365


Glu Lys Arg Phe Thr Phe Val Leu Ala Val Val Ile Gly Val Phe Val 
    370                 375                 380


Val Cys Trp Phe Pro Phe Phe Phe Thr Tyr Thr Leu Thr Ala Val Gly 
385                 390                 395                 400


Cys Ser Val Pro Arg Thr Leu Phe Lys Phe Phe Phe Trp Phe Gly Tyr 
                405                 410                 415


Cys Asn Ser Ser Leu Asn Pro Val Ile Tyr Thr Ile Phe Asn His Asp 
            420                 425                 430


Phe Arg Arg Ala Phe Lys Lys Ile Leu Cys Arg Gly Asp Arg Lys Arg 
        435                 440                 445


Ile Val 
    450


<210>  816
<211>  1628
<212>  DNA
<213>  Homo sapiens

<400>  816
cgggcgagga aggggcattt gcaccggggc tgggcgggcg cacccagagc caggcgggca     60

ggaacccctg cgcagccatc cggtgcctgc atgtccctgg cgcggaaggg acgcctcacc    120

agcctcggcg ccccctcccc ctagatttcc tccccgcccc tccccactgc ctgcctgctg    180

caccaccttc cacccagatc acccagatcg tctctaaagg gagttcttgg tttccttcga    240

tttcttatga acccaggatg ggcagcaaag aagatgcggg caaggggtgt ccggcggccg    300

gtggcgtctc cagcttcacc atccagtcca tcctgggcgg gggcccctcg gaggcaccgc    360

gggagcccgt cggctggcca gccaggaagc gcagcctgtc cgtgtcctcg gaggaggagg    420

agccggacga cggctggaag gcgcccgcct gcttctgccc agaccagcac ggccctaagg    480

agcagggccc caagcaccat ccccccatcc cttttccttg cctgggtacc cccaagggca    540

gcggaggctc gggcccgggc ggcttggagc gcacgccttt cctctctcct tcgcactcgg    600

actttaaaga agagaaagag aggctcctgc ccgcgggctc gccctcgccg gggtccgagc    660

ggccgcggga cggcggcgct gagcggcagg ccggcgcggc caagaagaag acgcgcaccg    720

tcttttcgcg cagccaggtg taccagctcg agtccacctt cgacatgaag cgctacctga    780

gcagctcgga gcgcgcctgc ctcgcctcca gcctgcagct cacggagacc caggtaaaga    840

cttggttcca gaaccgccgc aacaagtgga agcggcagct ctcggctgag ctggaggcgg    900

ccaacatggc gcacgcgtcg gcgcagactc tggtgagcat gccgctggtg ttccgggaca    960

gttcgctgct gcgcgtgccg gtgccgcgct cgctcgcctt tcccgcgccg ctctactacc   1020

cgggaagcaa cctctcggcc ttacctctct acaacctata caacaagctc gactactgac   1080

cggcccgccg ccccgcgccg cccccagctg cccgcagagc cgggcgcgta ctgtactgta   1140

agcagggctc cggagcaagg cggcgtgttt ccagaaatat gaagaaatac accatgtgta   1200

ttcattagct cttatttatg gtctctgccc tactttttgt tttgattgtt tcgggtattt   1260

attggcattc cctaagtcag agagcctgct tcctacctag accgaaccag tacgctttga   1320

aaaccattcg gagtgagatg ttctcgggtg gtggtgggaa agggagtttt ggccagacag   1380

gctgtggttg gtagggaaaa aaatcaggaa aacacctaca aaaccaggta cactcctccc   1440

ccatatatac acctgtatat atgtacatgc atacacgctc ggccaagcca ggccctcaga   1500

ggctttggac aattactaaa ttgcttcttt tcgtttccct catcccgagg atggtaggga   1560

cgaaaagggg agagttcaga tctgtaaata tttttaaaaa gaaaaaaaaa taaaacattt   1620

taaacatc                                                            1628


<210>  817
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  817

Met Gly Ser Lys Glu Asp Ala Gly Lys Gly Cys Pro Ala Ala Gly Gly 
1               5                   10                  15


Val Ser Ser Phe Thr Ile Gln Ser Ile Leu Gly Gly Gly Pro Ser Glu 
            20                  25                  30


Ala Pro Arg Glu Pro Val Gly Trp Pro Ala Arg Lys Arg Ser Leu Ser 
        35                  40                  45


Val Ser Ser Glu Glu Glu Glu Pro Asp Asp Gly Trp Lys Ala Pro Ala 
    50                  55                  60


Cys Phe Cys Pro Asp Gln His Gly Pro Lys Glu Gln Gly Pro Lys His 
65                  70                  75                  80


His Pro Pro Ile Pro Phe Pro Cys Leu Gly Thr Pro Lys Gly Ser Gly 
                85                  90                  95


Gly Ser Gly Pro Gly Gly Leu Glu Arg Thr Pro Phe Leu Ser Pro Ser 
            100                 105                 110


His Ser Asp Phe Lys Glu Glu Lys Glu Arg Leu Leu Pro Ala Gly Ser 
        115                 120                 125


Pro Ser Pro Gly Ser Glu Arg Pro Arg Asp Gly Gly Ala Glu Arg Gln 
    130                 135                 140


Ala Gly Ala Ala Lys Lys Lys Thr Arg Thr Val Phe Ser Arg Ser Gln 
145                 150                 155                 160


Val Tyr Gln Leu Glu Ser Thr Phe Asp Met Lys Arg Tyr Leu Ser Ser 
                165                 170                 175


Ser Glu Arg Ala Cys Leu Ala Ser Ser Leu Gln Leu Thr Glu Thr Gln 
            180                 185                 190


Val Lys Thr Trp Phe Gln Asn Arg Arg Asn Lys Trp Lys Arg Gln Leu 
        195                 200                 205


Ser Ala Glu Leu Glu Ala Ala Asn Met Ala His Ala Ser Ala Gln Thr 
    210                 215                 220


Leu Val Ser Met Pro Leu Val Phe Arg Asp Ser Ser Leu Leu Arg Val 
225                 230                 235                 240


Pro Val Pro Arg Ser Leu Ala Phe Pro Ala Pro Leu Tyr Tyr Pro Gly 
                245                 250                 255


Ser Asn Leu Ser Ala Leu Pro Leu Tyr Asn Leu Tyr Asn Lys Leu Asp 
            260                 265                 270


Tyr 



<210>  818
<211>  1432
<212>  DNA
<213>  Homo sapiens

<400>  818
ggcaggtcta cactggagct tcctctccgc ctccttcgcc tagcctgcga gtgttctgag     60

ggaagcaagg aggcggcggc ggccgcagcg agtggcgagt agtggaaacg ttgcttctga    120

ggggagccca agatgaccgg ttctaacgag ttcaagctga accagccacc cgaggatggc    180

atctcctccg tgaagttcag ccccaacacc tcccagttcc tgcttgtctc ctcctgggac    240

acgtccgtgc gtctctacga tgtgccggcc aactccatgc ggctcaagta ccagcacacc    300

ggcgccgtcc tggactgcgc cttctacgat ccaacgcatg cctggagtgg aggactagat    360

catcaattga aaatgcatga tttgaacact gatcaagaaa atcttgttgg gacccatgat    420

gcccctatca gatgtgttga atactgtcca gaagtgaatg tgatggtcac tggaagttgg    480

gatcagacag ttaaactgtg ggatcccaga actccttgta atgctgggac cttctctcag    540

cctgaaaagg tatataccct ctcagtgtct ggagaccggc tgattgtggg aacagcaggc    600

cgcagagtgt tggtgtggga cttacggaac atgggttacg tgcagcagcg cagggagtcc    660

agcctgaaat accagactcg ctgcatacga gcgtttccaa acaagcaggg ttatgtatta    720

agctctattg aaggccgagt ggcagttgag tatttggacc caagccctga ggtacagaag    780

aagaagtatg ccttcaaatg tcacagacta aaagaaaata atattgagca gatttaccca    840

gtcaatgcca tttcttttca caatatccac aatacatttg ccacaggtgg ttctgatggc    900

tttgtaaata tttgggatcc atttaacaaa aagcgactgt gccaattcca tcggtacccc    960

acgagcatcg catcacttgc cttcagtaat gatgggacta cgcttgcaat agcgtcatca   1020

tatatgtatg aaatggatga cacagaacat cctgaagatg gtatcttcat tcgccaagtg   1080

acagatgcag aaacaaaacc caagtccacc taatcatcct gtgaaagtgg tttctctatg   1140

gaaagctttg tttgcttcct acaaatacat gcttattcct taagggatgt gttagagtta   1200

ctgtggattt ctctgttttc tgtcttacaa gaaacttgtc tatgtacctt aatactttgt   1260

ttaggatgag gagtctttgt gtccctgtac agtagtctga cgtatttccc cttctgtccc   1320

ctagtaagcc cagttgctgt atctgaacag tttgagctct ttttgtaata tactctaaac   1380

ctgttatttc tgtgctaata aacgagatgc agaacccttg aaaaaaaaaa aa           1432


<210>  819
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  819

Met Thr Gly Ser Asn Glu Phe Lys Leu Asn Gln Pro Pro Glu Asp Gly 
1               5                   10                  15


Ile Ser Ser Val Lys Phe Ser Pro Asn Thr Ser Gln Phe Leu Leu Val 
            20                  25                  30


Ser Ser Trp Asp Thr Ser Val Arg Leu Tyr Asp Val Pro Ala Asn Ser 
        35                  40                  45


Met Arg Leu Lys Tyr Gln His Thr Gly Ala Val Leu Asp Cys Ala Phe 
    50                  55                  60


Tyr Asp Pro Thr His Ala Trp Ser Gly Gly Leu Asp His Gln Leu Lys 
65                  70                  75                  80


Met His Asp Leu Asn Thr Asp Gln Glu Asn Leu Val Gly Thr His Asp 
                85                  90                  95


Ala Pro Ile Arg Cys Val Glu Tyr Cys Pro Glu Val Asn Val Met Val 
            100                 105                 110


Thr Gly Ser Trp Asp Gln Thr Val Lys Leu Trp Asp Pro Arg Thr Pro 
        115                 120                 125


Cys Asn Ala Gly Thr Phe Ser Gln Pro Glu Lys Val Tyr Thr Leu Ser 
    130                 135                 140


Val Ser Gly Asp Arg Leu Ile Val Gly Thr Ala Gly Arg Arg Val Leu 
145                 150                 155                 160


Val Trp Asp Leu Arg Asn Met Gly Tyr Val Gln Gln Arg Arg Glu Ser 
                165                 170                 175


Ser Leu Lys Tyr Gln Thr Arg Cys Ile Arg Ala Phe Pro Asn Lys Gln 
            180                 185                 190


Gly Tyr Val Leu Ser Ser Ile Glu Gly Arg Val Ala Val Glu Tyr Leu 
        195                 200                 205


Asp Pro Ser Pro Glu Val Gln Lys Lys Lys Tyr Ala Phe Lys Cys His 
    210                 215                 220


Arg Leu Lys Glu Asn Asn Ile Glu Gln Ile Tyr Pro Val Asn Ala Ile 
225                 230                 235                 240


Ser Phe His Asn Ile His Asn Thr Phe Ala Thr Gly Gly Ser Asp Gly 
                245                 250                 255


Phe Val Asn Ile Trp Asp Pro Phe Asn Lys Lys Arg Leu Cys Gln Phe 
            260                 265                 270


His Arg Tyr Pro Thr Ser Ile Ala Ser Leu Ala Phe Ser Asn Asp Gly 
        275                 280                 285


Thr Thr Leu Ala Ile Ala Ser Ser Tyr Met Tyr Glu Met Asp Asp Thr 
    290                 295                 300


Glu His Pro Glu Asp Gly Ile Phe Ile Arg Gln Val Thr Asp Ala Glu 
305                 310                 315                 320


Thr Lys Pro Lys Ser Thr 
                325


<210>  820
<211>  2659
<212>  DNA
<213>  Homo sapiens

<400>  820
ggcaggtcta cactggagct tcctctccgc ctccttcgcc tagcctgcga gtgttctgag     60

ggaagcaagg aggcggcggc ggccgcagcg agtggcgagt agtggaaacg ttgcttctga    120

ggggagccca agatgaccgg ttctaacgag ttcaagctga accagccacc cgaggatggc    180

atctcctccg tgaagttcag ccccaacacc tcccagttcc tgcttgtctc ctcctgggac    240

acgtccgtgc gtctctacga tgtgccggcc aactccatgc ggctcaagta ccagcacacc    300

ggcgccgtcc tggactgcgc cttctacgat ccaacgcatg cctggagtgg aggactagat    360

catcaattga aaatgcatga tttgaacact gatcaagaaa atcttgttgg gacccatgat    420

gcccctatca gatgtgttga atactgtcca gaagtgaatg tgatggtcac tggaagttgg    480

gatcagacag ttaaactgtg ggatcccaga actccttgta atgctgggac cttctctcag    540

cctgaaaagg tatataccct ctcagtgtct ggagaccggc tgattgtggg aacagcaggc    600

cgcagagtgt tggtgtggga cttacggaac atgggttacg tgcagcagcg cagggagtcc    660

agcctgaaat accagactcg ctgcatacga gcgtttccaa acaagcaggg ttatgtatta    720

agctctattg aaggccgagt ggcagttgag tatttggacc caagccctga ggtacagaag    780

aagaagtatg ccttcaaatg tcacagacta aaagaaaata atattgagca gatttaccca    840

gtcaatgcca tttcttttca caatatccac aatacatttg ccacaggtgg ttctgatggc    900

tttgtaaata tttgggatcc atttaacaaa aagcgactgt gccaattcca tcggtacccc    960

acgagcatcg catcacttgc cttcagtaat gatgggacta cgcttgcaat agcgtcatca   1020

tatatgtatg aaatggatga cacagaacat cctgaagatg gtatcttcat tcgccaagtg   1080

acagatgcag aaacaaaacc caagtcacca tgtacttgac aagatttcat ttacttaagt   1140

gccatgttga tgataataaa acaattcgta ctccccaatg gtggatttat tactattaaa   1200

gaaaccaggg aaaatattaa ttttaatatt ataacaacct gaaaataatg gaaaagaggt   1260

ttttgaattt ttttttttaa ataaacacct tcttaagtgc atgagatggt ttgatggttt   1320

gctgcattaa aggtatttgg gcaaacaaaa ttggagggca agtgactgca gttttgagaa   1380

tcagttttga ccttgatgat tttttgtttc cactgtggaa ataaatgttt gtaaataagt   1440

gtaataaaaa tccctttgca ttctttctgg accttaaatg gtagaggaaa aggctcgtga   1500

gccatttgtt tcttttgctg gttatagttg ctaattctaa agctgcttca gactgcttca   1560

tgaggaggtt aatctacaat taaacaatat ttcctcttgg ccgtccatta ttttctgaag   1620

cagatggttc atcatttcct gggctgttaa acaaagcgag gttaaggtta gactcttggg   1680

aatcagctag ttttcaatct tattagggtg cagaaggaaa actaataaga aaacctccta   1740

atatcatttt gtgactgtaa acaattattt attagcaaac aattgatccc agaagggcaa   1800

attgtttgag tcagtaatga gctgagaaaa gacagagcat atctgtgtat ttggaaaaat   1860

aattgtaacg taattgcagt gcatttagac aggcatctat ttggacctgt ttctatctct   1920

aaatgaattt ttggaaacat taatgaggtt tacatatttc tctgacattt atatagttct   1980

tatgtccatt tcagttgacc agccgctggt gattaaagtt aaaaagaaaa aaattatagt   2040

gagaatgaga ttcatttcaa tgtaatgcac taaagcagaa cacgaactta gcttggccta   2100

ttctaggtag ttccaaatag tatttttgtt gtcaaacttt aaaatttata ttaatttgca   2160

aatgtatgtc tctgagtagg acttggacct ttcctgagat ttattttatc cgtgatgtat   2220

tttttttaat tcttttgata cagagaaggg tctttttttt tttaagtatt tcagtgaaaa   2280

cttggtgtaa gtctgaaccc atcttttgaa atgtattttc ttcattgcag gtccacctaa   2340

tcatcctgtg aaagtggttt ctctatggaa agctttgttt gcttcctaca aatacatgct   2400

tattccttaa gggatgtgtt agagttactg tggatttctc tgttttctgt cttacaagaa   2460

acttgtctat gtaccttaat actttgttta ggatgaggag tctttgtgtc cctgtacagt   2520

agtctgacgt atttcccctt ctgtccccta gtaagcccag ttgctgtatc tgaacagttt   2580

gagctctttt tgtaatatac tctaaacctg ttatttctgt gctaataaac gagatgcaga   2640

acccttgaaa aaaaaaaaa                                                2659


<210>  821
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  821

Met Thr Gly Ser Asn Glu Phe Lys Leu Asn Gln Pro Pro Glu Asp Gly 
1               5                   10                  15


Ile Ser Ser Val Lys Phe Ser Pro Asn Thr Ser Gln Phe Leu Leu Val 
            20                  25                  30


Ser Ser Trp Asp Thr Ser Val Arg Leu Tyr Asp Val Pro Ala Asn Ser 
        35                  40                  45


Met Arg Leu Lys Tyr Gln His Thr Gly Ala Val Leu Asp Cys Ala Phe 
    50                  55                  60


Tyr Asp Pro Thr His Ala Trp Ser Gly Gly Leu Asp His Gln Leu Lys 
65                  70                  75                  80


Met His Asp Leu Asn Thr Asp Gln Glu Asn Leu Val Gly Thr His Asp 
                85                  90                  95


Ala Pro Ile Arg Cys Val Glu Tyr Cys Pro Glu Val Asn Val Met Val 
            100                 105                 110


Thr Gly Ser Trp Asp Gln Thr Val Lys Leu Trp Asp Pro Arg Thr Pro 
        115                 120                 125


Cys Asn Ala Gly Thr Phe Ser Gln Pro Glu Lys Val Tyr Thr Leu Ser 
    130                 135                 140


Val Ser Gly Asp Arg Leu Ile Val Gly Thr Ala Gly Arg Arg Val Leu 
145                 150                 155                 160


Val Trp Asp Leu Arg Asn Met Gly Tyr Val Gln Gln Arg Arg Glu Ser 
                165                 170                 175


Ser Leu Lys Tyr Gln Thr Arg Cys Ile Arg Ala Phe Pro Asn Lys Gln 
            180                 185                 190


Gly Tyr Val Leu Ser Ser Ile Glu Gly Arg Val Ala Val Glu Tyr Leu 
        195                 200                 205


Asp Pro Ser Pro Glu Val Gln Lys Lys Lys Tyr Ala Phe Lys Cys His 
    210                 215                 220


Arg Leu Lys Glu Asn Asn Ile Glu Gln Ile Tyr Pro Val Asn Ala Ile 
225                 230                 235                 240


Ser Phe His Asn Ile His Asn Thr Phe Ala Thr Gly Gly Ser Asp Gly 
                245                 250                 255


Phe Val Asn Ile Trp Asp Pro Phe Asn Lys Lys Arg Leu Cys Gln Phe 
            260                 265                 270


His Arg Tyr Pro Thr Ser Ile Ala Ser Leu Ala Phe Ser Asn Asp Gly 
        275                 280                 285


Thr Thr Leu Ala Ile Ala Ser Ser Tyr Met Tyr Glu Met Asp Asp Thr 
    290                 295                 300


Glu His Pro Glu Asp Gly Ile Phe Ile Arg Gln Val Thr Asp Ala Glu 
305                 310                 315                 320


Thr Lys Pro Lys Ser Pro Cys Thr 
                325


<210>  822
<211>  6751
<212>  DNA
<213>  Homo sapiens

<400>  822
gaatggaaaa tggcggccta gacgcggagt ttcctgcccg acccgcggcg gctccggcgg     60

cgccatgacg cgctgggtgc ccaccaagcg cgaggagaag tacggcgtgg ctttttataa    120

ctatgatgcc agaggagcgg atgaactttc tttacagatc ggagacactg tgcacatctt    180

agaaacatat gaagggtggt accgaggtta cacgttacga aaaaagtcta agaagggtat    240

atttcctgct tcatatattc atcttaaaga agcgatagtt gaaggaaaag ggcaacatga    300

aacagtcatc ccgggtgacc tccccctcat ccaggaagtc accacgacac tccgagagtg    360

gtccaccatc tggaggcagc tctacgtgca agataacagg gagatgtttc gaagtgtgcg    420

gcacatgatc tatgacctta ttgaatggcg atcacaaatt ctttctggaa ctctgcctca    480

ggatgaactc aaagaactga agaagaaggt cacagccaaa attgattatg gaaacagaat    540

tctagatttg gacctggtgg ttagagatga agatgggaat attttggatc cagaattaac    600

tagcacgatt agtctcttca gagctcatga aatagcttct aaacaagtgg aggaaaggtt    660

acaagaggaa aaatctcaaa agcagaacat agatattaac agacaagcca agtttgctgc    720

aaccccttct ctggccttgt ttgtgaacct caaaaatgtg gtttgtaaaa taggagaaga    780

tgctgaagtc ctcatgtctc tatatgaccc tgtggagtcc aaattcatca gtgagaacta    840

cctggttcgc tggtccagtt caggattacc taaagacata gacagattac ataatttgcg    900

agccgtgttt actgacctcg gaagcaaaga cctgaaaagg gagaaaatca gttttgtctg    960

tcagattgtt cgcgtgggtc gcatggagct gagggacaac aacaccagga aactgacctc   1020

ggggttgcgg cgaccttttg gagtggctgt gatggatgta acagatataa taaatggaaa   1080

agtagatgat gaagataagc agcatttcat tccctttcag ccggtggcag gggagaatga   1140

cttccttcag actgttataa acaaagtcat cgctgccaaa gaagtcaacc acaaggggca   1200

gggtttgtgg gtaacattga aattacttcc tggagatatc catcagatcc gaaaagagtt   1260

tccgcattta gtggacagga ccacagctgt ggctcgaaaa acagggtttc cggagataat   1320

catgcctggt gatgttcgaa atgatatcta tgtaacatta gttcaaggag attttgataa   1380

aggaagcaaa acaacagcga agaacgtgga ggtcacggtg tctgtgtacg atgaggatgg   1440

gaaacgatta gagcatgtga ttttcccggg tgctggtgat gaagcgattt cagagtacaa   1500

atctgtgatt tactaccaag taaagcagcc acgctggttt gagactgtta aggtggccat   1560

tcccatcgag gacgttaacc gcagtcacct tcggtttacc ttccgccaca ggtcatcaca   1620

ggactctaag gataaatctg agaaaatatt tgcactagca tttgtcaagc tgatgagata   1680

cgatggtacc accctgcgag acggagagca cgatcttatc gtctataagg ccgaagcaaa   1740

gaagctggaa gatgctgcca cgtacttgag tctgccctcc acgaaggcag agttggaaga   1800

aaagggccac tcggccaccg gcaagagcat gcagagcctt gggagctgca ccattagcaa   1860

ggactccttc cagatctcca cgctcgtgtg ctccaccaaa ctgactcaga acgtggacct   1920

tctggggctc ttgaaatggc gctccaacac cagcctgctg cagcagaact tgaggcagct   1980

gatgaaagtc gatggtggtg aagtagtgaa gtttcttcag gacacgttgg atgccctctt   2040

caacatcatg atggagaact cagagagtga gacttttgac acgttagtct ttgatgctct   2100

ggtatttatc attggactga ttgctgatag aaaatttcag cattttaatc ctgttttgga   2160

aacttacatt aagaaacact ttagtgcaac gttagcctac acgaagttga caaaagtgtt   2220

gaagaactac gtggacggtg ctgagaagcc gggagtaaat gagcagctgt acaaagccat   2280

gaaagcgcta gaatccatct tcaagttcat cgtgcgctcc aggatcctgt tcaatcaact   2340

gtatgaaaac aagggagagg ctgacttcgt ggaatctttg ctgcagctct tcaggtccat   2400

caatgacatg atgagcagca tgtcagacca gaccgtccgg gtgaaggggg cagcactgaa   2460

atacttacca acgatcgtca acgatgtgaa attggtgttt gatcccaaag agctcagcaa   2520

aatgtttact gaattcatcc tcaatgttcc catgggcttg ctgaccatcc agaaactcta   2580

ctgcttgatc gaaatcgtcc acagtgacct cttcacacag catgactgca gagagatcct   2640

gcttcccatg atgaccgatc agctcaagta ccatctggag agacaggagg acctggaggc   2700

ctgctgtcag ctgctcagcc acatcctgga ggtgctgtac aggaaggacg tggggccaac   2760

ccagaggcac gtccagatta tcatggagaa acttctccgg accgtgaacc gaaccgtcat   2820

ttccatggga cgagattctg aactcattgg aaacttcgtg gcttgcatga cagctatttt   2880

acgacaaatg gaagattacc attatgccca cttgatcaag acttttggga aaatgaggac   2940

tgatgtggta gatttcctaa tggaaacatt catcatgttt aagaacctca ttggaaagaa   3000

cgtttacccc ttcgactggg tgatcatgaa catggtgcaa aataaagtct tcctgcgagc   3060

aattaatcag tatgcagata tgctgaacaa aaaatttctg gatcaagcca actttgagct   3120

acagctgtgg aacaactact ttcacctggc tgttgctttc cttactcaag agtccctgca   3180

actggagaat ttttcaagtg ccaagagagc caaaatcctt aacaagtacg gagatatgag   3240

gagacagatt ggctttgaaa tcagagacat gtggtacaac cttggtcaac acaagataaa   3300

gttcattcca gaaatggtgg gcccaatatt agaaatgaca ttaattcccg agacggagct   3360

gcgcaaagcc accatcccca tcttctttga tatgatgcag tgtgaattcc attcgacccg   3420

aagcttccaa atgtttgaaa atgagatcat caccaagctg gatcatgaag tcgaaggagg   3480

cagaggagac gaacagtaca aagtgttatt tgataaaatc cttctggaac actgcaggaa   3540

gcacaaatac ctcgccaaaa caggagaaac ttttgtaaaa ctcgttgtgc gcttaatgga   3600

aaggcttttg gattatagaa ccatcatgca cgacgagaac aaagaaaacc gcatgagctg   3660

caccgtcaat gtgctgaatt tctacaaaga aattgaaaga gaagaaatgt atataaggta   3720

tttgtacaag ctctgtgacc tgcacaagga gtgtgataac tacaccgaag cggcttacac   3780

cttgcttctc catgcaaagc ttcttaagtg gtcggaggat gtgtgtgtgg cccacctcac   3840

ccagcgggac gggtaccagg ccaccacgca gggacagctg aaggagcagc tctaccagga   3900

aatcatccac tacttcgaca aaggcaagat gtgggaggag gccattgcct tgggcaagga   3960

gctagccgag cagtatgaga acgaaatgtt tgattatgag caactcagcg aattgctgaa   4020

aaaacaggct cagttttatg aaaacatcgt caaagtgatc aggcccaagc ctgactattt   4080

tgctgttggc tactacggac aagggttccc cacattcctg cggggaaaag ttttcattta   4140

ccgagggaaa gagtatgagc gccgggaaga ttttgaggct cggctcttaa ctcagtttcc   4200

aaacgccgag aaaatgaaga caacatctcc accaggcgac gatattaaaa actctcctgg   4260

ccagtatatt cagtgcttca cagtgaagcc caaactcgat ctgcctccta agtttcacag   4320

gccagtgtca gagcagattg taagttttta cagggtgaac gaggtccagc gatttgaata   4380

ttctcggcca atccggaagg gagagaaaaa cccagacaat gaatttgcga atatgtggat   4440

cgagagaacc atatatacaa ctgcatataa attacctgga attttaaggt ggtttgaggt   4500

caagtctgtt ttcatggtgg aaatcagccc cctggagaat gccattgaga ccatgcagct   4560

gacgaacgac aagatcaaca gcatggtgca gcagcacctg gatgacccca gcctgcccat   4620

caacccgctc tccatgctcc tgaacggcat cgtggaccca gctgtcatgg ggggcttcgc   4680

aaactacgaa aaggccttct ttacagaccg gtacctgcag gagcaccctg aggcccatga   4740

aaagatcgag aagctcaagg acctgattgc ttggcagatt ccttttctgg ccgaagggat   4800

cagaatccat ggagacaaag tcacggaggc actgaggccg ttccacgaga ggatggaggc   4860

ctgtttcaaa cagctgaagg aaaaggtgga gaaagagtac ggcgtccgaa tcatgccctc   4920

aagtctggat gatagaagag gcagccgccc ccggtccatg gtgcggtcct tcacgatgcc   4980

ttcctcatcc cgccctctgt ctgtggcctc tgtctcttcc ctctcatcgg acagcacccc   5040

ttccagacca ggctccgacg ggtttgccct ggagcctctc ctgccaaaga aaatgcactc   5100

caggtcccag gacaagctgg acaaggatga cctggagaag gagaagaagg acaagaagaa   5160

ggaaaaaagg aacagcaaac atcaagagat atttgagaaa gaatttaaac ccaccgacat   5220

ttccctgcag cagtctgagg ctgtgatcct ttcggaaacg ataagtcccc tgcggcccca   5280

gagaccgaag agccaggtga tgaacgtcat tggaagcgaa aggcgcttct cggtgtcccc   5340

ctcgtcaccg tcctcccagc aaacaccccc tccagttaca ccaagggcca agctcagctt   5400

cagcatgcag tcgagcttgg agctgaacgg catgacgggg gcggacgtgg ccgatgtccc   5460

accccctctg cctctcaaag gcagcgtggc agattacggg aatttgatgg aaaaccagga   5520

cttgctgggc tcgccaacac ctccacctcc ccctccacac cagaggcatc tgccacctcc   5580

actgcccagc aaaactccgc ctcctccccc tccaaagaca actcgcaagc agacatcggt   5640

ggactccggg atcgtgcagt gacgtcgcaa gcctctctgg aaagagtgtg ctgcccctcc   5700

ccatctccat gccctctcct tctgtgtccc ctgagtctgc tgtttacctc attgggcctg   5760

tgatgttaac atttcgtgcg actgcttttt cttcaaagga gttcagttct caccatggag   5820

tgagtggcct ttagcgtcat ggagcaaggt gggtctggga ggtagatatg ggtccgggat   5880

gtgctatcgt agttatcaga gttgggggcc tctgagtgtg tctggctctg agagagtctg   5940

agtcttgccc aaacattctt tctttttgtg ccaaatgact tgcatttgca aagagctcaa   6000

ttgctctgag ctcagccaag taggagaggc taggccatca ctcttaggaa gctgtgtagt   6060

gatgatgtat aagaatcctc ctcactgtca tgggatgttg tatccagccc ctccttgttc   6120

cagccggtgg tgtgacttcg ttggttgagg tgtgtctcca acctacatca gaccatgaag   6180

ttcaacccct ccagggaagc tcctgatttc ccctgcataa ttgaaaatag gatatttctc   6240

agctattgaa cagttactaa tttatggggt ggaaacagca ttaagaatac tgaatcaaat   6300

ggaaaaacaa atgaatacag gaagataagt gttcgttctt ttctgaaaaa gagtatgtgt   6360

accacaagag ctggttttaa ttgggtgaat tgtttttgtc ctcattctgt acagaaattt   6420

gtatatatga tggttcttag aacttgtttt aatttttgtg gtccttccgt ttattataat   6480

aggcgtccac caatgattat ccatatgtgt tcttaatttt taactgctgg aagtgttaaa   6540

acacacacac acacacacac acattttttt tttgagaact ccaaagtcct gaaaattttg   6600

gtggacaatg atttttaaaa aactaacttt gtataaccta atatttgtat tctctcatct   6660

atattttttt attcactata atcatgatac tcttctaata gacttaaaag ttaatcattg   6720

acaacgaaaa ataaaatgtt attttaaaag a                                  6751


<210>  823
<211>  1865
<212>  PRT
<213>  Homo sapiens

<400>  823

Met Thr Arg Trp Val Pro Thr Lys Arg Glu Glu Lys Tyr Gly Val Ala 
1               5                   10                  15


Phe Tyr Asn Tyr Asp Ala Arg Gly Ala Asp Glu Leu Ser Leu Gln Ile 
            20                  25                  30


Gly Asp Thr Val His Ile Leu Glu Thr Tyr Glu Gly Trp Tyr Arg Gly 
        35                  40                  45


Tyr Thr Leu Arg Lys Lys Ser Lys Lys Gly Ile Phe Pro Ala Ser Tyr 
    50                  55                  60


Ile His Leu Lys Glu Ala Ile Val Glu Gly Lys Gly Gln His Glu Thr 
65                  70                  75                  80


Val Ile Pro Gly Asp Leu Pro Leu Ile Gln Glu Val Thr Thr Thr Leu 
                85                  90                  95


Arg Glu Trp Ser Thr Ile Trp Arg Gln Leu Tyr Val Gln Asp Asn Arg 
            100                 105                 110


Glu Met Phe Arg Ser Val Arg His Met Ile Tyr Asp Leu Ile Glu Trp 
        115                 120                 125


Arg Ser Gln Ile Leu Ser Gly Thr Leu Pro Gln Asp Glu Leu Lys Glu 
    130                 135                 140


Leu Lys Lys Lys Val Thr Ala Lys Ile Asp Tyr Gly Asn Arg Ile Leu 
145                 150                 155                 160


Asp Leu Asp Leu Val Val Arg Asp Glu Asp Gly Asn Ile Leu Asp Pro 
                165                 170                 175


Glu Leu Thr Ser Thr Ile Ser Leu Phe Arg Ala His Glu Ile Ala Ser 
            180                 185                 190


Lys Gln Val Glu Glu Arg Leu Gln Glu Glu Lys Ser Gln Lys Gln Asn 
        195                 200                 205


Ile Asp Ile Asn Arg Gln Ala Lys Phe Ala Ala Thr Pro Ser Leu Ala 
    210                 215                 220


Leu Phe Val Asn Leu Lys Asn Val Val Cys Lys Ile Gly Glu Asp Ala 
225                 230                 235                 240


Glu Val Leu Met Ser Leu Tyr Asp Pro Val Glu Ser Lys Phe Ile Ser 
                245                 250                 255


Glu Asn Tyr Leu Val Arg Trp Ser Ser Ser Gly Leu Pro Lys Asp Ile 
            260                 265                 270


Asp Arg Leu His Asn Leu Arg Ala Val Phe Thr Asp Leu Gly Ser Lys 
        275                 280                 285


Asp Leu Lys Arg Glu Lys Ile Ser Phe Val Cys Gln Ile Val Arg Val 
    290                 295                 300


Gly Arg Met Glu Leu Arg Asp Asn Asn Thr Arg Lys Leu Thr Ser Gly 
305                 310                 315                 320


Leu Arg Arg Pro Phe Gly Val Ala Val Met Asp Val Thr Asp Ile Ile 
                325                 330                 335


Asn Gly Lys Val Asp Asp Glu Asp Lys Gln His Phe Ile Pro Phe Gln 
            340                 345                 350


Pro Val Ala Gly Glu Asn Asp Phe Leu Gln Thr Val Ile Asn Lys Val 
        355                 360                 365


Ile Ala Ala Lys Glu Val Asn His Lys Gly Gln Gly Leu Trp Val Thr 
    370                 375                 380


Leu Lys Leu Leu Pro Gly Asp Ile His Gln Ile Arg Lys Glu Phe Pro 
385                 390                 395                 400


His Leu Val Asp Arg Thr Thr Ala Val Ala Arg Lys Thr Gly Phe Pro 
                405                 410                 415


Glu Ile Ile Met Pro Gly Asp Val Arg Asn Asp Ile Tyr Val Thr Leu 
            420                 425                 430


Val Gln Gly Asp Phe Asp Lys Gly Ser Lys Thr Thr Ala Lys Asn Val 
        435                 440                 445


Glu Val Thr Val Ser Val Tyr Asp Glu Asp Gly Lys Arg Leu Glu His 
    450                 455                 460


Val Ile Phe Pro Gly Ala Gly Asp Glu Ala Ile Ser Glu Tyr Lys Ser 
465                 470                 475                 480


Val Ile Tyr Tyr Gln Val Lys Gln Pro Arg Trp Phe Glu Thr Val Lys 
                485                 490                 495


Val Ala Ile Pro Ile Glu Asp Val Asn Arg Ser His Leu Arg Phe Thr 
            500                 505                 510


Phe Arg His Arg Ser Ser Gln Asp Ser Lys Asp Lys Ser Glu Lys Ile 
        515                 520                 525


Phe Ala Leu Ala Phe Val Lys Leu Met Arg Tyr Asp Gly Thr Thr Leu 
    530                 535                 540


Arg Asp Gly Glu His Asp Leu Ile Val Tyr Lys Ala Glu Ala Lys Lys 
545                 550                 555                 560


Leu Glu Asp Ala Ala Thr Tyr Leu Ser Leu Pro Ser Thr Lys Ala Glu 
                565                 570                 575


Leu Glu Glu Lys Gly His Ser Ala Thr Gly Lys Ser Met Gln Ser Leu 
            580                 585                 590


Gly Ser Cys Thr Ile Ser Lys Asp Ser Phe Gln Ile Ser Thr Leu Val 
        595                 600                 605


Cys Ser Thr Lys Leu Thr Gln Asn Val Asp Leu Leu Gly Leu Leu Lys 
    610                 615                 620


Trp Arg Ser Asn Thr Ser Leu Leu Gln Gln Asn Leu Arg Gln Leu Met 
625                 630                 635                 640


Lys Val Asp Gly Gly Glu Val Val Lys Phe Leu Gln Asp Thr Leu Asp 
                645                 650                 655


Ala Leu Phe Asn Ile Met Met Glu Asn Ser Glu Ser Glu Thr Phe Asp 
            660                 665                 670


Thr Leu Val Phe Asp Ala Leu Val Phe Ile Ile Gly Leu Ile Ala Asp 
        675                 680                 685


Arg Lys Phe Gln His Phe Asn Pro Val Leu Glu Thr Tyr Ile Lys Lys 
    690                 695                 700


His Phe Ser Ala Thr Leu Ala Tyr Thr Lys Leu Thr Lys Val Leu Lys 
705                 710                 715                 720


Asn Tyr Val Asp Gly Ala Glu Lys Pro Gly Val Asn Glu Gln Leu Tyr 
                725                 730                 735


Lys Ala Met Lys Ala Leu Glu Ser Ile Phe Lys Phe Ile Val Arg Ser 
            740                 745                 750


Arg Ile Leu Phe Asn Gln Leu Tyr Glu Asn Lys Gly Glu Ala Asp Phe 
        755                 760                 765


Val Glu Ser Leu Leu Gln Leu Phe Arg Ser Ile Asn Asp Met Met Ser 
    770                 775                 780


Ser Met Ser Asp Gln Thr Val Arg Val Lys Gly Ala Ala Leu Lys Tyr 
785                 790                 795                 800


Leu Pro Thr Ile Val Asn Asp Val Lys Leu Val Phe Asp Pro Lys Glu 
                805                 810                 815


Leu Ser Lys Met Phe Thr Glu Phe Ile Leu Asn Val Pro Met Gly Leu 
            820                 825                 830


Leu Thr Ile Gln Lys Leu Tyr Cys Leu Ile Glu Ile Val His Ser Asp 
        835                 840                 845


Leu Phe Thr Gln His Asp Cys Arg Glu Ile Leu Leu Pro Met Met Thr 
    850                 855                 860


Asp Gln Leu Lys Tyr His Leu Glu Arg Gln Glu Asp Leu Glu Ala Cys 
865                 870                 875                 880


Cys Gln Leu Leu Ser His Ile Leu Glu Val Leu Tyr Arg Lys Asp Val 
                885                 890                 895


Gly Pro Thr Gln Arg His Val Gln Ile Ile Met Glu Lys Leu Leu Arg 
            900                 905                 910


Thr Val Asn Arg Thr Val Ile Ser Met Gly Arg Asp Ser Glu Leu Ile 
        915                 920                 925


Gly Asn Phe Val Ala Cys Met Thr Ala Ile Leu Arg Gln Met Glu Asp 
    930                 935                 940


Tyr His Tyr Ala His Leu Ile Lys Thr Phe Gly Lys Met Arg Thr Asp 
945                 950                 955                 960


Val Val Asp Phe Leu Met Glu Thr Phe Ile Met Phe Lys Asn Leu Ile 
                965                 970                 975


Gly Lys Asn Val Tyr Pro Phe Asp Trp Val Ile Met Asn Met Val Gln 
            980                 985                 990


Asn Lys Val Phe Leu Arg Ala Ile Asn Gln Tyr Ala Asp Met Leu Asn 
        995                 1000                1005


Lys Lys Phe Leu Asp Gln Ala Asn Phe Glu Leu Gln Leu Trp Asn Asn 
    1010                1015                1020


Tyr Phe His Leu Ala Val Ala Phe Leu Thr Gln Glu Ser Leu Gln Leu 
1025                1030                1035                1040


Glu Asn Phe Ser Ser Ala Lys Arg Ala Lys Ile Leu Asn Lys Tyr Gly 
                1045                1050                1055


Asp Met Arg Arg Gln Ile Gly Phe Glu Ile Arg Asp Met Trp Tyr Asn 
            1060                1065                1070


Leu Gly Gln His Lys Ile Lys Phe Ile Pro Glu Met Val Gly Pro Ile 
        1075                1080                1085


Leu Glu Met Thr Leu Ile Pro Glu Thr Glu Leu Arg Lys Ala Thr Ile 
    1090                1095                1100


Pro Ile Phe Phe Asp Met Met Gln Cys Glu Phe His Ser Thr Arg Ser 
1105                1110                1115                1120


Phe Gln Met Phe Glu Asn Glu Ile Ile Thr Lys Leu Asp His Glu Val 
                1125                1130                1135


Glu Gly Gly Arg Gly Asp Glu Gln Tyr Lys Val Leu Phe Asp Lys Ile 
            1140                1145                1150


Leu Leu Glu His Cys Arg Lys His Lys Tyr Leu Ala Lys Thr Gly Glu 
        1155                1160                1165


Thr Phe Val Lys Leu Val Val Arg Leu Met Glu Arg Leu Leu Asp Tyr 
    1170                1175                1180


Arg Thr Ile Met His Asp Glu Asn Lys Glu Asn Arg Met Ser Cys Thr 
1185                1190                1195                1200


Val Asn Val Leu Asn Phe Tyr Lys Glu Ile Glu Arg Glu Glu Met Tyr 
                1205                1210                1215


Ile Arg Tyr Leu Tyr Lys Leu Cys Asp Leu His Lys Glu Cys Asp Asn 
            1220                1225                1230


Tyr Thr Glu Ala Ala Tyr Thr Leu Leu Leu His Ala Lys Leu Leu Lys 
        1235                1240                1245


Trp Ser Glu Asp Val Cys Val Ala His Leu Thr Gln Arg Asp Gly Tyr 
    1250                1255                1260


Gln Ala Thr Thr Gln Gly Gln Leu Lys Glu Gln Leu Tyr Gln Glu Ile 
1265                1270                1275                1280


Ile His Tyr Phe Asp Lys Gly Lys Met Trp Glu Glu Ala Ile Ala Leu 
                1285                1290                1295


Gly Lys Glu Leu Ala Glu Gln Tyr Glu Asn Glu Met Phe Asp Tyr Glu 
            1300                1305                1310


Gln Leu Ser Glu Leu Leu Lys Lys Gln Ala Gln Phe Tyr Glu Asn Ile 
        1315                1320                1325


Val Lys Val Ile Arg Pro Lys Pro Asp Tyr Phe Ala Val Gly Tyr Tyr 
    1330                1335                1340


Gly Gln Gly Phe Pro Thr Phe Leu Arg Gly Lys Val Phe Ile Tyr Arg 
1345                1350                1355                1360


Gly Lys Glu Tyr Glu Arg Arg Glu Asp Phe Glu Ala Arg Leu Leu Thr 
                1365                1370                1375


Gln Phe Pro Asn Ala Glu Lys Met Lys Thr Thr Ser Pro Pro Gly Asp 
            1380                1385                1390


Asp Ile Lys Asn Ser Pro Gly Gln Tyr Ile Gln Cys Phe Thr Val Lys 
        1395                1400                1405


Pro Lys Leu Asp Leu Pro Pro Lys Phe His Arg Pro Val Ser Glu Gln 
    1410                1415                1420


Ile Val Ser Phe Tyr Arg Val Asn Glu Val Gln Arg Phe Glu Tyr Ser 
1425                1430                1435                1440


Arg Pro Ile Arg Lys Gly Glu Lys Asn Pro Asp Asn Glu Phe Ala Asn 
                1445                1450                1455


Met Trp Ile Glu Arg Thr Ile Tyr Thr Thr Ala Tyr Lys Leu Pro Gly 
            1460                1465                1470


Ile Leu Arg Trp Phe Glu Val Lys Ser Val Phe Met Val Glu Ile Ser 
        1475                1480                1485


Pro Leu Glu Asn Ala Ile Glu Thr Met Gln Leu Thr Asn Asp Lys Ile 
    1490                1495                1500


Asn Ser Met Val Gln Gln His Leu Asp Asp Pro Ser Leu Pro Ile Asn 
1505                1510                1515                1520


Pro Leu Ser Met Leu Leu Asn Gly Ile Val Asp Pro Ala Val Met Gly 
                1525                1530                1535


Gly Phe Ala Asn Tyr Glu Lys Ala Phe Phe Thr Asp Arg Tyr Leu Gln 
            1540                1545                1550


Glu His Pro Glu Ala His Glu Lys Ile Glu Lys Leu Lys Asp Leu Ile 
        1555                1560                1565


Ala Trp Gln Ile Pro Phe Leu Ala Glu Gly Ile Arg Ile His Gly Asp 
    1570                1575                1580


Lys Val Thr Glu Ala Leu Arg Pro Phe His Glu Arg Met Glu Ala Cys 
1585                1590                1595                1600


Phe Lys Gln Leu Lys Glu Lys Val Glu Lys Glu Tyr Gly Val Arg Ile 
                1605                1610                1615


Met Pro Ser Ser Leu Asp Asp Arg Arg Gly Ser Arg Pro Arg Ser Met 
            1620                1625                1630


Val Arg Ser Phe Thr Met Pro Ser Ser Ser Arg Pro Leu Ser Val Ala 
        1635                1640                1645


Ser Val Ser Ser Leu Ser Ser Asp Ser Thr Pro Ser Arg Pro Gly Ser 
    1650                1655                1660


Asp Gly Phe Ala Leu Glu Pro Leu Leu Pro Lys Lys Met His Ser Arg 
1665                1670                1675                1680


Ser Gln Asp Lys Leu Asp Lys Asp Asp Leu Glu Lys Glu Lys Lys Asp 
                1685                1690                1695


Lys Lys Lys Glu Lys Arg Asn Ser Lys His Gln Glu Ile Phe Glu Lys 
            1700                1705                1710


Glu Phe Lys Pro Thr Asp Ile Ser Leu Gln Gln Ser Glu Ala Val Ile 
        1715                1720                1725


Leu Ser Glu Thr Ile Ser Pro Leu Arg Pro Gln Arg Pro Lys Ser Gln 
    1730                1735                1740


Val Met Asn Val Ile Gly Ser Glu Arg Arg Phe Ser Val Ser Pro Ser 
1745                1750                1755                1760


Ser Pro Ser Ser Gln Gln Thr Pro Pro Pro Val Thr Pro Arg Ala Lys 
                1765                1770                1775


Leu Ser Phe Ser Met Gln Ser Ser Leu Glu Leu Asn Gly Met Thr Gly 
            1780                1785                1790


Ala Asp Val Ala Asp Val Pro Pro Pro Leu Pro Leu Lys Gly Ser Val 
        1795                1800                1805


Ala Asp Tyr Gly Asn Leu Met Glu Asn Gln Asp Leu Leu Gly Ser Pro 
    1810                1815                1820


Thr Pro Pro Pro Pro Pro Pro His Gln Arg His Leu Pro Pro Pro Leu 
1825                1830                1835                1840


Pro Ser Lys Thr Pro Pro Pro Pro Pro Pro Lys Thr Thr Arg Lys Gln 
                1845                1850                1855


Thr Ser Val Asp Ser Gly Ile Val Gln 
            1860                1865


<210>  824
<211>  1011
<212>  DNA
<213>  Homo sapiens

<400>  824
aaaccaccca ccttcaccat gtctgacgag gaagttgaac aggtggagga gcagtacgaa     60

gaagaagagg aagcccagga ggaagaggaa gttcaagaag acaccgcaga ggaggacgcg    120

gaagaggaga aaccgagacc caaactcact gctcctaaga tcccagaagg ggagaaagtg    180

gacttcgatg acatccagaa gaagcgtcag aacaaagacc taatggagct ccaggccctc    240

atcgacagcc actttgaagc ccggaagaag gaggaggagg agctggtcgc tctcaaagag    300

agaatcgaga agcgccgtgc agagagagcg gagcagcaga ggattcgtgc agagaaggag    360

agggagcgcc agaacagact ggcggaggaa aaggccagaa gggaggagga ggatgccaag    420

aggagggcag aggacgacct gaagaagaag aaagctctgt cttccatggg agccaactac    480

agcagctacc tggccaaggc tgaccagaag agaggcaaga agcagacagc ccgggaaatg    540

aagaagaaga ttctggctga gagacgcaag ccgctcaaca tcgatcacct tggtgaagac    600

aaactgaggg acaaggccaa ggagctctgg gagaccctgc accagctgga gattgacaag    660

ttcgagtttg gggagaagct gaaacgccag aaatatgaca tcaccacgct caggagccgc    720

attgaccagg cccagaagca cagcaagaag gctgggaccc cagccaaggg caaagtcggc    780

gggcgctgga agtagagagg ccagaaaggc ccctcgaggc agagaccctc cgccctcttg    840

cacaccaggg ccgctcgtgg gactccacat cctccagccc ccacaatcct gtcaggggct    900

ccctgacagt cctgggggtg gagaggccat cccggggcgt cccccgcgtc tgtgtccttg    960

ctgccttcat cccctggggc ctgtgaataa agctgcagaa cccccttcaa a            1011


<210>  825
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  825

Met Ser Asp Glu Glu Val Glu Gln Val Glu Glu Gln Tyr Glu Glu Glu 
1               5                   10                  15


Glu Glu Ala Gln Glu Glu Glu Glu Val Gln Glu Asp Thr Ala Glu Glu 
            20                  25                  30


Asp Ala Glu Glu Glu Lys Pro Arg Pro Lys Leu Thr Ala Pro Lys Ile 
        35                  40                  45


Pro Glu Gly Glu Lys Val Asp Phe Asp Asp Ile Gln Lys Lys Arg Gln 
    50                  55                  60


Asn Lys Asp Leu Met Glu Leu Gln Ala Leu Ile Asp Ser His Phe Glu 
65                  70                  75                  80


Ala Arg Lys Lys Glu Glu Glu Glu Leu Val Ala Leu Lys Glu Arg Ile 
                85                  90                  95


Glu Lys Arg Arg Ala Glu Arg Ala Glu Gln Gln Arg Ile Arg Ala Glu 
            100                 105                 110


Lys Glu Arg Glu Arg Gln Asn Arg Leu Ala Glu Glu Lys Ala Arg Arg 
        115                 120                 125


Glu Glu Glu Asp Ala Lys Arg Arg Ala Glu Asp Asp Leu Lys Lys Lys 
    130                 135                 140


Lys Ala Leu Ser Ser Met Gly Ala Asn Tyr Ser Ser Tyr Leu Ala Lys 
145                 150                 155                 160


Ala Asp Gln Lys Arg Gly Lys Lys Gln Thr Ala Arg Glu Met Lys Lys 
                165                 170                 175


Lys Ile Leu Ala Glu Arg Arg Lys Pro Leu Asn Ile Asp His Leu Gly 
            180                 185                 190


Glu Asp Lys Leu Arg Asp Lys Ala Lys Glu Leu Trp Glu Thr Leu His 
        195                 200                 205


Gln Leu Glu Ile Asp Lys Phe Glu Phe Gly Glu Lys Leu Lys Arg Gln 
    210                 215                 220


Lys Tyr Asp Ile Thr Thr Leu Arg Ser Arg Ile Asp Gln Ala Gln Lys 
225                 230                 235                 240


His Ser Lys Lys Ala Gly Thr Pro Ala Lys Gly Lys Val Gly Gly Arg 
                245                 250                 255


Trp Lys 



<210>  826
<211>  701
<212>  DNA
<213>  Homo sapiens

<400>  826
gggcgggcgc gctgctcctt ccgcctcgcg gaccccggaa gcgcgcgtgg ccgccatggc     60

gcggaatgtg gtgtaccccc tgtaccggct gggtggccca caacttcggg tgttccgaac    120

caacttcttc attcagctgg tgcggcccgg tgtggcccag cccgaggaca ccgtgcagtt    180

ccggatcccc atggaaatga caagggtgga cctcaggaat tacctcgagg gcatctataa    240

cgtgcccgtg gctgctgtgc ggacacgggt gcagcatggc tctaacaaga gaagagatca    300

cagaaacgtg aggatcaaga agccggacta caaggtcgcc tacgtgcagc tggcccatgg    360

acagaccttc acgttcccag atctgtttcc cgagaaagac gagagccctg aaggcagcac    420

tgccgacgac ctctacagca tgctcgagga ggagaggcag cagaggcaga gcagcgaccc    480

gcggcggggc ggcgtcccca gctggttcgg gctgtgacgg ggtggccagc agggacgcgc    540

cccaggtggg cagctgtggc agagcagcga cccgcggcgg ggcggcatcc ccagctggtt    600

cgggccgtga cggggcggcc agcagggacg cgccccaggt gggcagctgt ggcagagcag    660

tcccgacacc taaataaaag tcttgctgca ggagaaagaa a                        701


<210>  827
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  827

Met Ala Arg Asn Val Val Tyr Pro Leu Tyr Arg Leu Gly Gly Pro Gln 
1               5                   10                  15


Leu Arg Val Phe Arg Thr Asn Phe Phe Ile Gln Leu Val Arg Pro Gly 
            20                  25                  30


Val Ala Gln Pro Glu Asp Thr Val Gln Phe Arg Ile Pro Met Glu Met 
        35                  40                  45


Thr Arg Val Asp Leu Arg Asn Tyr Leu Glu Gly Ile Tyr Asn Val Pro 
    50                  55                  60


Val Ala Ala Val Arg Thr Arg Val Gln His Gly Ser Asn Lys Arg Arg 
65                  70                  75                  80


Asp His Arg Asn Val Arg Ile Lys Lys Pro Asp Tyr Lys Val Ala Tyr 
                85                  90                  95


Val Gln Leu Ala His Gly Gln Thr Phe Thr Phe Pro Asp Leu Phe Pro 
            100                 105                 110


Glu Lys Asp Glu Ser Pro Glu Gly Ser Thr Ala Asp Asp Leu Tyr Ser 
        115                 120                 125


Met Leu Glu Glu Glu Arg Gln Gln Arg Gln Ser Ser Asp Pro Arg Arg 
    130                 135                 140


Gly Gly Val Pro Ser Trp Phe Gly Leu 
145                 150


<210>  828
<211>  2322
<212>  DNA
<213>  Homo sapiens

<400>  828
gggagggggt gggatgggtg gggggtaacg ggggaaactg gggaagtggg gaaccgaggg     60

gcaaccaggg gaagatgggg tgctggagga gagcttgtgg gagccaagga gcaccttgga    120

catctggagt ctggcaggag tgatgacggg tggaggggct agctcgaggc agggctggtg    180

gggcctgagg ccagtgagga gtgtggagta ggcgcccagg catcgtgcag acagggcgac    240

atcagctggg gacgatgggc ctgagctagg gctggaaaga agggggagcc aggcattcat    300

cccggtcact tttggttaca ggacgtggca gctggttgga cgaggggagc tggtgggcag    360

ggtttgatcc cagggcctgg gcaacggagg tgtagctggc agcagcgggc aggtgaggac    420

cccatctgcc gggcaggtga gtcccttccc tccccaggcc tcgcttcccc agccttctga    480

aagaaggagg tttaggggat cgagggctgg cggggagaag cagacaccct cccagcagag    540

gggcaggatg ggggcaggag agttagcaaa ggtgacatct tctcgggggg agccgagact    600

gcgcaaggct ggggggttat gggcccgttc caggcagaaa gagcaagagg gcagggaggg    660

agcacagggg tggccagcgt agggtccagc acgtggggtg gtaccccagg cctgggtcag    720

acagggacat ggcaggggac acaggacaga ggggtcccca gctgccacct cacccaccgc    780

aattcattta gtagcaggca caggggcagc tccggcacgg ctttctcagg cctatgccgg    840

agcctcgagg gctggagagc gggaagacag gcagtgctcg gggagttgca gcaggacgtc    900

accaggaggg cgaagcggcc acgggagggg ggccccggga cattgcgcag caaggaggct    960

gcaggggctc ggcctgcggg cgccggtccc acgaggcact gcggcccagg gtctggtgcg   1020

gagagggccc acagtggact tggtgacgct gtatgccctc accgctcagc ccctggggct   1080

ggcttggcag acagtacagc atccagggga gtcaagggca tggggcgaga ccagactagg   1140

cgaggcgggc ggggcggagt gaatgagctc tcaggaggga ggatggtgca ggcaggggtg   1200

aggagcgcag cgggcggcga gcgggaggca ctggcctcca gagcccgtgg ccaaggcggg   1260

cctcgcgggc ggcgacggag ccgggatcgg tgcctcagcg ttcgggctgg agacgaggcc   1320

aggtctccag ctggggtgga cgtgcccacc agctgccgaa ggccaagacg ccaggtccgg   1380

tggacgtgac aagcaggaca tgacatggtc cggtgtgacg gcgaggacag aggaggcgcg   1440

tccggccttc ctgaacacct taggctggtg gggctgcggc aagaagcggg tctgtttctt   1500

tacttcctcc acggagtcgg cacactatgg ctgccctctg ggctcccaga acccacaaca   1560

tgaaagaaat ggtgctaccc agctcaagcc tgggcctttg aatccggaca caaaaccctc   1620

tagcttggaa atgaatatgc tgcactttac aaccactgca ctacctgact caggaatcgg   1680

ctctggaagg tgaagctaga ggaaccagac ctcatcagcc caacatcaaa gacaccatcg   1740

gaacagcagc gcccgcagca cccaccccgc accggcgact ccatcttcat ggccaccccc   1800

tgcggcggac ggttgaccac cagccaccac atcatcccag agctgagctc ctccagcggg   1860

atgacgccgt ccccaccacc tccctcttct tctttttcat ccttctgtct ctttgtttct   1920

gagctttcct gtctttcctt ttttctgaga gattcaaagc ctccacgact ctgtttcccc   1980

cgtcccttct gaatttaatt tgcactaagt catttgcact ggttggagtt gtggagacgg   2040

ccttgagtct cagtacgagt gtgcgtgagt gtgagccacc ttggcaagtg cctgtgcagg   2100

gcccggccgc cctccatctg ggccgggtga ctgggcgccg gctgtgtgcc cgaggcctca   2160

ccctgccctc gcctagtctg gaagctccga ccgacatcac ggagcagcct tcaagcattc   2220

cattacgccc catctcgctc tgtgcccctc cccaccaggg cttcagcagg agccctggac   2280

tcatcatcaa taaacactgt tacagcaaaa aaaaaaaaaa aa                      2322


<210>  829
<211>  5165
<212>  DNA
<213>  Homo sapiens

<400>  829
cgcctgtccc cctcccgagg cccgggctcg cgacggcaga gggctccgtc ggcccaaacc     60

gagctgggcg cccgcggtcc gggtgcagcc tccactccgc cccccagtca ccgcctcccc    120

cggcccctcg acgtggcgcc cttccctccg cttctctgtg ctccccgcgc ccctcttggc    180

gtctggcccc ggcccccgct ctttctcccg caaccttccc ttcgctccct cccgtccccc    240

ccagctccta gcctccgact ccctcccccc ctcacgcccg ccctctcgcc ttcgccgaac    300

caaagtggat taattacacg ctttctgttt ctctccgtgc tgttctctcc cgctgtgcgc    360

ctgcccgcct ctcgctgtcc tctctccccc tcgccctctc ttcggccccc ccctttcacg    420

ttcactctgt ctctcccact atctctgccc ccctctatcc ttgatacaac agctgacctc    480

atttcccgat accttttccc ccccgaaaag tacaacatct ggcccgcccc agcccgaaga    540

cagcccgtcc tccctggaca atcagacgaa ttctcccccc ccccccaaaa aaaagccatc    600

cccccgctct gccccgtcgc acattcggcc cccgcgactc ggccagagcg gcgctggcag    660

aggagtgtcc ggcaggaggg ccaacgcccg ctgttcggtt tgcgacacgc agcagggagg    720

tgggcggcag cgtcgccggc ttccagacac caatgggaat cccaatgggg aagtcgatgc    780

tggtgcttct caccttcttg gccttcgcct cgtgctgcat tgctgcttac cgccccagtg    840

agaccctgtg cggcggggag ctggtggaca ccctccagtt cgtctgtggg gaccgcggct    900

tctacttcag caggcccgca agccgtgtga gccgtcgcag ccgtggcatc gttgaggagt    960

gctgtttccg cagctgtgac ctggccctcc tggagacgta ctgtgctacc cccgccaagt   1020

ccgagaggga cgtgtcgacc cctccgaccg tgcttccgga caacttcccc agataccccg   1080

tgggcaagtt cttccaatat gacacctgga agcagtccac ccagcgcctg cgcaggggcc   1140

tgcctgccct cctgcgtgcc cgccggggtc acgtgctcgc caaggagctc gaggcgttca   1200

gggaggccaa acgtcaccgt cccctgattg ctctacccac ccaagacccc gcccacgggg   1260

gcgccccccc agagatggcc agcaatcgga agtgagcaaa actgccgcaa gtctgcagcc   1320

cggcgccacc atcctgcagc ctcctcctga ccacggacgt ttccatcagg ttccatcccg   1380

aaaatctctc ggttccacgt ccccctgggg cttctcctga cccagtcccc gtgccccgcc   1440

tccccgaaac aggctactct cctcggcccc ctccatcggg ctgaggaagc acagcagcat   1500

cttcaaacat gtacaaaatc gattggcttt aaacaccctt cacataccct ccccccaaat   1560

tatccccaat tatccccaca cataaaaaat caaaacatta aactaacccc cttccccccc   1620

ccccacaaca accctcttaa aactaattgg ctttttagaa acaccccaca aaagctcaga   1680

aattggcttt aaaaaaaaca accaccaaaa aaaatcaatt ggctaaaaaa aaaaagtatt   1740

aaaaacgaat tggctgagaa acaattggca aaataaagga atttggcact ccccaccccc   1800

ctctttctct tctcccttgg actttgagtc aaattggcct ggacttgagt ccctgaacca   1860

gcaaagagaa aagaaggacc ccagaaatca caggtgggca cgtcgctgct accgccatct   1920

cccttctcac gggaattttc agggtaaact ggccatccga aaatagcaac aacccagact   1980

ggctcctcac tcccttttcc atcactaaaa atcacagagc agtcagaggg acccagtaag   2040

accaaaggag gggaggacag agcatgaaaa ccaaaatcca tgcaaatgaa atgtaattgg   2100

cacgaccctc acccccaaat cttacatctc aattcccatc ctaaaaagca ctcatacttt   2160

atgcatcccc gcagctacac acacacaaca cacagcacac gcatgaacac agcacacaca   2220

cgagcacagc acacacacaa acgcacagca cacacagcac acagatgagc acacagcaca   2280

cacacaaacg cacagcacac acacgcacac acatgcacac acagcacaca aacgcacggc   2340

acacacacgc acacacatgc acacacagca cacacacaaa cgcacagcac acacaaacgc   2400

acagcacaca cgcacacaca gcacacacac gagcacacag cacacaaacg cacagcacac   2460

gcacacacat gcacacacag cacacacact agcacacagc acacacacaa agacacagca   2520

cacacatgca cacacagcac acacacgcga acacagcaca cacgaacaca gcacacacag   2580

cacacacaca aacacagcac acacatgcac acagcacacg cacacacagc acacacatga   2640

acacagcaca cagcacacac atgcacacac agcacacacg catgcacagc acacatgaac   2700

acagcacaca cacaaacaca cagcacacac atgcacacac agcacacaca ctcatgcgca   2760

gcacatacat gaacacagct cacagcacac aaacacgcag cacacacgtt gcacacgcaa   2820

gcacccacct gcacacacac atgcgcacac acacgcacac ccccacaaaa ttggatgaaa   2880

acaataagca tatctaagca actacgatat ctgtatggat caggccaaag tcccgctaag   2940

attctccaat gttttcatgg tctgagcccc gctcctgttc ccatctccac tgcccctcgg   3000

ccctgtctgt gccctgcctc tcagaggagg gggctcagat ggtgcggcct gagtgtgcgg   3060

ccggcggcat ttgggataca cccgtagggt gggcggggtg tgtcccaggc ctaattccat   3120

ctttccacca tgacagagat gcccttgtga ggctggcctc cttggcgcct gtccccacgg   3180

cccccgcagc gtgagccacg atgctcccca taccccaccc attcccgata caccttactt   3240

actgtgtgtt ggcccagcca gagtgaggaa ggagtttggc cacattggag atggcggtag   3300

ctgagcagac atgcccccac gagtagcctg actccctggt gtgctcctgg aaggaagatc   3360

ttggggaccc ccccaccgga gcacacctag ggatcatctt tgcccgtctc ctggggaccc   3420

cccaagaaat gtggagtcct cgggggccgt gcactgatgc ggggagtgtg ggaagtctgg   3480

cggttggagg ggtgggtggg gggcagtggg ggctgggcgg ggggagttct ggggtaggaa   3540

gtggtcccgg gagattttgg atggaaaagt caggaggatt gacagcagac ttgcagaatt   3600

acatagagaa attaggaacc cccaaatttc atgtcaattg atctattccc cctctttgtt   3660

tcttggggca tttttccttt tttttttttt tttgtttttt ttttacccct ccttagcttt   3720

atgcgctcag aaaccaaatt aaaccccccc cccatgtaac aggggggcag tgacaaaagc   3780

aagaacgcac gaagccagcc tggagaccac cacgtcctgc cccccgccat ttatcgccct   3840

gattggattt tgtttttcat ctgtccctgt tgcttgggtt gagttgaggg tggagcctcc   3900

tggggggcac tggccactga gcccccttgg agaagtcaga ggggagtgga gaaggccact   3960

gtccggcctg gcttctgggg acagtggctg gtccccagaa gtcctgaggg cggagggggg   4020

ggttgggcag ggtctcctca ggtgtcagga gggtgctcgg aggccacagg agggggctcc   4080

tggctggcct gaggctggcc ggaggggaag gggctagcag gtgtgtaaac agagggttcc   4140

atcaggctgg ggcagggtgg ccgccttccg cacacttgag gaaccctccc ctctccctcg   4200

gtgacatctt gcccgcccct cagcaccctg ccttgtctcc aggaggtccg aagctctgtg   4260

ggacctcttg ggggcaaggt ggggtgaggc cggggagtag ggaggtcagg cgggtctgag   4320

cccacagagc aggagagctg ccaggtctgc ccatcgacca ggttgcttgg gccccggagc   4380

ccacgggtct ggtgatgcca tagcagccac caccgcggcg cctagggctg cggcagggac   4440

tcggcctctg ggaggtttac ctcgccccca cttgtgcccc cagctcagcc cccctgcacg   4500

cagcccgact agcagtctag aggcctgagg cttctgggtc ctggtgacgg ggctggcatg   4560

accccggggg tcgtccatgc cagtccgcct cagtcgcaga gggtccctcg gcaagcgccc   4620

tgtgagtggg ccattcggaa cattggacag aagcccaaag agccaaattg tcacaattgt   4680

ggaacccaca ttggcctgag atccaaaacg cttcgaggca ccccaaatta cctgcccatt   4740

cgtcaggaca cccacccacc cagtgttata ttctgcctcg ccggagtggg tgttcccggg   4800

ggcacttgcc gaccagcccc ttgcgtcccc aggtttgcag ctctcccctg ggccactaac   4860

catcctggcc cgggctgcct gtctgacctc cgtgcctagt cgtggctctc catcttgtct   4920

cctccccgtg tccccaatgt cttcagtggg gggccccctc ttgggtcccc tcctctgcca   4980

tcacctgaag acccccacgc caaacactga atgtcacctg tgcctgccgc ctcggtccac   5040

cttgcggccc gtgtttgact caactcaact cctttaacgc taatatttcc ggcaaaatcc   5100

catgcttggg ttttgtcttt aaccttgtaa cgcttgcaat cccaataaag cattaaaagt   5160

catga                                                               5165


<210>  830
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  830

Met Gly Ile Pro Met Gly Lys Ser Met Leu Val Leu Leu Thr Phe Leu 
1               5                   10                  15


Ala Phe Ala Ser Cys Cys Ile Ala Ala Tyr Arg Pro Ser Glu Thr Leu 
            20                  25                  30


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45


Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg 
    50                  55                  60


Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
65                  70                  75                  80


Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu Arg Asp Val Ser Thr 
                85                  90                  95


Pro Pro Thr Val Leu Pro Asp Asn Phe Pro Arg Tyr Pro Val Gly Lys 
            100                 105                 110


Phe Phe Gln Tyr Asp Thr Trp Lys Gln Ser Thr Gln Arg Leu Arg Arg 
        115                 120                 125


Gly Leu Pro Ala Leu Leu Arg Ala Arg Arg Gly His Val Leu Ala Lys 
    130                 135                 140


Glu Leu Glu Ala Phe Arg Glu Ala Lys Arg His Arg Pro Leu Ile Ala 
145                 150                 155                 160


Leu Pro Thr Gln Asp Pro Ala His Gly Gly Ala Pro Pro Glu Met Ala 
                165                 170                 175


Ser Asn Arg Lys 
            180


<210>  831
<211>  5139
<212>  DNA
<213>  Homo sapiens

<400>  831
ccgctaatgt accatgccct ggtgctggaa agtgcctgag ccagctgccc cagcggcctc     60

ggcactacca agttggcaca aagctcccca aattcggagg ggctcaggga aacgagtgga    120

ggggatgagg aggtgagggg taaacccatc atttcagttg gcatttgagc aggtgccatg    180

ctcagcggag atgaggctct cccatctgta ggggccgtat taacatgcac actctaaaag    240

tgcccttcgt ttctccagcc tcagctttgt ccctctcctc ctccacgtca acctggccag    300

agggtctgga cgccacagcc agggcacccc ctgctttggt ggtgactgct aatattggcc    360

aggccggcgg atcatcgtcc aggcagtttc ggcagagagc cttgggcacc agtgactccc    420

cggtcctctt tatccactgt ccaggagctg cggggactgc gcagggacta gagtacaggg    480

gccgaagagt caccaccgag cttgtgtggg aggaggtgga ttccagcccc cagccccagg    540

gctctgaatc gctgccagct cagccccctg cccagcctgc cccacagcct gagccccagc    600

aggccagaga gcccagtcct gaggtgagct gctgtggcct gtggcccagg cgaccccagc    660

gctcccagaa ctgaggctgg cagccagccc cagcctcagc cccaactgcg aggcagagag    720

acaccaatgg gaatcccaat ggggaagtcg atgctggtgc ttctcacctt cttggccttc    780

gcctcgtgct gcattgctgc ttaccgcccc agtgagaccc tgtgcggcgg ggagctggtg    840

gacaccctcc agttcgtctg tggggaccgc ggcttctact tcagcaggcc cgcaagccgt    900

gtgagccgtc gcagccgtgg catcgttgag gagtgctgtt tccgcagctg tgacctggcc    960

ctcctggaga cgtactgtgc tacccccgcc aagtccgaga gggacgtgtc gacccctccg   1020

accgtgcttc cggacaactt ccccagatac cccgtgggca agttcttcca atatgacacc   1080

tggaagcagt ccacccagcg cctgcgcagg ggcctgcctg ccctcctgcg tgcccgccgg   1140

ggtcacgtgc tcgccaagga gctcgaggcg ttcagggagg ccaaacgtca ccgtcccctg   1200

attgctctac ccacccaaga ccccgcccac gggggcgccc ccccagagat ggccagcaat   1260

cggaagtgag caaaactgcc gcaagtctgc agcccggcgc caccatcctg cagcctcctc   1320

ctgaccacgg acgtttccat caggttccat cccgaaaatc tctcggttcc acgtccccct   1380

ggggcttctc ctgacccagt ccccgtgccc cgcctccccg aaacaggcta ctctcctcgg   1440

ccccctccat cgggctgagg aagcacagca gcatcttcaa acatgtacaa aatcgattgg   1500

ctttaaacac ccttcacata ccctcccccc aaattatccc caattatccc cacacataaa   1560

aaatcaaaac attaaactaa cccccttccc ccccccccac aacaaccctc ttaaaactaa   1620

ttggcttttt agaaacaccc cacaaaagct cagaaattgg ctttaaaaaa aacaaccacc   1680

aaaaaaaatc aattggctaa aaaaaaaaag tattaaaaac gaattggctg agaaacaatt   1740

ggcaaaataa aggaatttgg cactccccac ccccctcttt ctcttctccc ttggactttg   1800

agtcaaattg gcctggactt gagtccctga accagcaaag agaaaagaag gaccccagaa   1860

atcacaggtg ggcacgtcgc tgctaccgcc atctcccttc tcacgggaat tttcagggta   1920

aactggccat ccgaaaatag caacaaccca gactggctcc tcactccctt ttccatcact   1980

aaaaatcaca gagcagtcag agggacccag taagaccaaa ggaggggagg acagagcatg   2040

aaaaccaaaa tccatgcaaa tgaaatgtaa ttggcacgac cctcaccccc aaatcttaca   2100

tctcaattcc catcctaaaa agcactcata ctttatgcat ccccgcagct acacacacac   2160

aacacacagc acacgcatga acacagcaca cacacgagca cagcacacac acaaacgcac   2220

agcacacaca gcacacagat gagcacacag cacacacaca aacgcacagc acacacacgc   2280

acacacatgc acacacagca cacaaacgca cggcacacac acgcacacac atgcacacac   2340

agcacacaca caaacgcaca gcacacacaa acgcacagca cacacgcaca cacagcacac   2400

acacgagcac acagcacaca aacgcacagc acacgcacac acatgcacac acagcacaca   2460

cactagcaca cagcacacac acaaagacac agcacacaca tgcacacaca gcacacacac   2520

gcgaacacag cacacacgaa cacagcacac acagcacaca cacaaacaca gcacacacat   2580

gcacacagca cacgcacaca cagcacacac atgaacacag cacacagcac acacatgcac   2640

acacagcaca cacgcatgca cagcacacat gaacacagca cacacacaaa cacacagcac   2700

acacatgcac acacagcaca cacactcatg cgcagcacat acatgaacac agctcacagc   2760

acacaaacac gcagcacaca cgttgcacac gcaagcaccc acctgcacac acacatgcgc   2820

acacacacgc acacccccac aaaattggat gaaaacaata agcatatcta agcaactacg   2880

atatctgtat ggatcaggcc aaagtcccgc taagattctc caatgttttc atggtctgag   2940

ccccgctcct gttcccatct ccactgcccc tcggccctgt ctgtgccctg cctctcagag   3000

gagggggctc agatggtgcg gcctgagtgt gcggccggcg gcatttggga tacacccgta   3060

gggtgggcgg ggtgtgtccc aggcctaatt ccatctttcc accatgacag agatgccctt   3120

gtgaggctgg cctccttggc gcctgtcccc acggcccccg cagcgtgagc cacgatgctc   3180

cccatacccc acccattccc gatacacctt acttactgtg tgttggccca gccagagtga   3240

ggaaggagtt tggccacatt ggagatggcg gtagctgagc agacatgccc ccacgagtag   3300

cctgactccc tggtgtgctc ctggaaggaa gatcttgggg acccccccac cggagcacac   3360

ctagggatca tctttgcccg tctcctgggg accccccaag aaatgtggag tcctcggggg   3420

ccgtgcactg atgcggggag tgtgggaagt ctggcggttg gaggggtggg tggggggcag   3480

tgggggctgg gcggggggag ttctggggta ggaagtggtc ccgggagatt ttggatggaa   3540

aagtcaggag gattgacagc agacttgcag aattacatag agaaattagg aacccccaaa   3600

tttcatgtca attgatctat tccccctctt tgtttcttgg ggcatttttc cttttttttt   3660

tttttttgtt ttttttttac ccctccttag ctttatgcgc tcagaaacca aattaaaccc   3720

cccccccatg taacaggggg gcagtgacaa aagcaagaac gcacgaagcc agcctggaga   3780

ccaccacgtc ctgccccccg ccatttatcg ccctgattgg attttgtttt tcatctgtcc   3840

ctgttgcttg ggttgagttg agggtggagc ctcctggggg gcactggcca ctgagccccc   3900

ttggagaagt cagaggggag tggagaaggc cactgtccgg cctggcttct ggggacagtg   3960

gctggtcccc agaagtcctg agggcggagg ggggggttgg gcagggtctc ctcaggtgtc   4020

aggagggtgc tcggaggcca caggaggggg ctcctggctg gcctgaggct ggccggaggg   4080

gaaggggcta gcaggtgtgt aaacagaggg ttccatcagg ctggggcagg gtggccgcct   4140

tccgcacact tgaggaaccc tcccctctcc ctcggtgaca tcttgcccgc ccctcagcac   4200

cctgccttgt ctccaggagg tccgaagctc tgtgggacct cttgggggca aggtggggtg   4260

aggccgggga gtagggaggt caggcgggtc tgagcccaca gagcaggaga gctgccaggt   4320

ctgcccatcg accaggttgc ttgggccccg gagcccacgg gtctggtgat gccatagcag   4380

ccaccaccgc ggcgcctagg gctgcggcag ggactcggcc tctgggaggt ttacctcgcc   4440

cccacttgtg cccccagctc agcccccctg cacgcagccc gactagcagt ctagaggcct   4500

gaggcttctg ggtcctggtg acggggctgg catgaccccg ggggtcgtcc atgccagtcc   4560

gcctcagtcg cagagggtcc ctcggcaagc gccctgtgag tgggccattc ggaacattgg   4620

acagaagccc aaagagccaa attgtcacaa ttgtggaacc cacattggcc tgagatccaa   4680

aacgcttcga ggcaccccaa attacctgcc cattcgtcag gacacccacc cacccagtgt   4740

tatattctgc ctcgccggag tgggtgttcc cgggggcact tgccgaccag ccccttgcgt   4800

ccccaggttt gcagctctcc cctgggccac taaccatcct ggcccgggct gcctgtctga   4860

cctccgtgcc tagtcgtggc tctccatctt gtctcctccc cgtgtcccca atgtcttcag   4920

tggggggccc cctcttgggt cccctcctct gccatcacct gaagaccccc acgccaaaca   4980

ctgaatgtca cctgtgcctg ccgcctcggt ccaccttgcg gcccgtgttt gactcaactc   5040

aactccttta acgctaatat ttccggcaaa atcccatgct tgggttttgt ctttaacctt   5100

gtaacgcttg caatcccaat aaagcattaa aagtcatga                          5139


<210>  832
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  832

Met Gly Ile Pro Met Gly Lys Ser Met Leu Val Leu Leu Thr Phe Leu 
1               5                   10                  15


Ala Phe Ala Ser Cys Cys Ile Ala Ala Tyr Arg Pro Ser Glu Thr Leu 
            20                  25                  30


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45


Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg 
    50                  55                  60


Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
65                  70                  75                  80


Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu Arg Asp Val Ser Thr 
                85                  90                  95


Pro Pro Thr Val Leu Pro Asp Asn Phe Pro Arg Tyr Pro Val Gly Lys 
            100                 105                 110


Phe Phe Gln Tyr Asp Thr Trp Lys Gln Ser Thr Gln Arg Leu Arg Arg 
        115                 120                 125


Gly Leu Pro Ala Leu Leu Arg Ala Arg Arg Gly His Val Leu Ala Lys 
    130                 135                 140


Glu Leu Glu Ala Phe Arg Glu Ala Lys Arg His Arg Pro Leu Ile Ala 
145                 150                 155                 160


Leu Pro Thr Gln Asp Pro Ala His Gly Gly Ala Pro Pro Glu Met Ala 
                165                 170                 175


Ser Asn Arg Lys 
            180


<210>  833
<211>  2071
<212>  DNA
<213>  Homo sapiens

<400>  833
cggagtccta ggcccgcggg ctagaggcac tttaccgccc ggcgggagcg cctctcctcc     60

gcgtccctcg ccccagcccc ctgcccgccc cactttggga ccctccagcc gctttcccca    120

caaatgagat ctttgcaatg agcaaacgaa agtggcgcgg atttcggggc gcccagcagg    180

agcgagcgca gccgccagcc gcaagtccgc agccgtgtcc cgcgccccac gccggcctcc    240

ccggcggcag ccggagacga gcgccagcac cggcgggaca gcagcagatg cgggccgaga    300

gccggtcagg ggcgcagagg cggaggggat cggcgcggcg gggagctcac cgcgaagctg    360

gaggctgcgt ccgcgggcgc accaggagct caggcagcga gcgatcgaac gctctgtggc    420

aggcggtgga cgctgctgaa gctctggctc tgagctcacc gctccgccgt ccgtgggacc    480

aagcccagca ttttacaaac ccagctcctt tctccaaggg tcctcagagc gcccctccgt    540

caccccctgc agggcgccgc agacgaggcg ctgaccttgc gctcactccc ctcgctgggg    600

aaggacacac tcgctggcgt cagcccggcc ggcctgggaa gtaggactaa ggacccgaac    660

tgcaaccctc cacaccagac agcacagacc accccaaggc tgctcaatct gcccaaagcc    720

aaaagagctc ccctgccagg acctcggtgc cgtggagact gcggggaacc tgctctgccc    780

acacctgctc tggcccctag acggaagcac ctggagccaa ccacggaact ccagatccca    840

gctgtgtgac tgaatccacg ccagcctctc tgagccaaag ctgcttgcag aagggggaga    900

tcccagttcg aagactcccg cgcagagcct gtggccctct ctgccaggcc tcagggtgcc    960

tgagacactc acctctctgc ctcgcagttg gggctgaggc tggggctggc tgccagcctc   1020

agttctggga gcgctggggt cgcctgggcc acaggccaca gcagctcacc tcaggactgg   1080

gctctctggc ctgctggggc tcaggctgtg gggcaggctg ggcagggggc tgagctggca   1140

gcgattcaga gccctggggc tgggggctgg aatccacctc ctcccacaca agctcggtgg   1200

tgactcttcg gcccctgggg aaaaacaaaa agatattgct gagatgacct cttttaaaag   1260

caaagccccc ctccccatac accccaagcc tgagccctgt cccatccccc tccccgggtt   1320

ccttcaggtc accttgtcag gatctgggca gcggcttccc cctctagccc ctcccctgcc   1380

tagagctccc tctttcaaag tataagggag ggaagaagtg gtgagaagtt tgcctagaaa   1440

gggcttcccg gtgctgatgg agaggccgag acccttctgt tggacaggct gccctgttcc   1500

tgggtgagga tgggcttctg cctggcactg ggggtggagg gtgcacacga atggcccgcc   1560

ttgaggggtc atggcacgga atatgaaagc ctcctccacc tccaaacacc cccaccttgg   1620

aaggagataa ggagggggcc ccagcaaaag ccactggaca cacagctctg cttgacgagg   1680

ccagtgaggg acggcgtggc tgtgcttcct ggggaaatga accccctccc cacagacacc   1740

accctgggtg gatcgaggag tctgggtcca gggtgcaaca gagaaaaact tcatgcatga   1800

atgagcattc ccagggaaac tgccttggcc ccagggcgcc tctctgtgcc agggaggctg   1860

ggagagcagc aagggggacc aggtgcgcca tcaggaggag agaagctaaa cctagggggg   1920

acatggaggg cggttgttgc ctctcccggc atttctcctc agtctcctgt ccaatttctt   1980

gctggtggtc aggaggcata gggaggcagg agggaaggaa gctttacctg taaaatggtg   2040

tatatatgta taaataaaat ctctgcgcca g                                  2071


<210>  834
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  834

Met Ser Lys Arg Lys Trp Arg Gly Phe Arg Gly Ala Gln Gln Glu Arg 
1               5                   10                  15


Ala Gln Pro Pro Ala Ala Ser Pro Gln Pro Cys Pro Ala Pro His Ala 
            20                  25                  30


Gly Leu Pro Gly Gly Ser Arg Arg Arg Ala Pro Ala Pro Ala Gly Gln 
        35                  40                  45


Gln Gln Met Arg Ala Glu Ser Arg Ser Gly Ala Gln Arg Arg Arg Gly 
    50                  55                  60


Ser Ala Arg Arg Gly Ala His Arg Glu Ala Gly Gly Cys Val Arg Gly 
65                  70                  75                  80


Arg Thr Arg Ser Ser Gly Ser Glu Arg Ser Asn Ala Leu Trp Gln Ala 
                85                  90                  95


Val Asp Ala Ala Glu Ala Leu Ala Leu Ser Ser Pro Leu Arg Arg Pro 
            100                 105                 110


Trp Asp Gln Ala Gln His Phe Thr Asn Pro Ala Pro Phe Ser Lys Gly 
        115                 120                 125


Pro Gln Ser Ala Pro Pro Ser Pro Pro Ala Gly Arg Arg Arg Arg Gly 
    130                 135                 140


Ala Asp Leu Ala Leu Thr Pro Leu Ala Gly Glu Gly His Thr Arg Trp 
145                 150                 155                 160


Arg Gln Pro Gly Arg Pro Gly Lys 
                165


<210>  835
<211>  469
<212>  DNA
<213>  Homo sapiens

<400>  835
agccctccag gacaggctgc atcagaagag gccatcaagc agatcactgt ccttctgcca     60

tggccctgtg gatgcgcctc ctgcccctgc tggcgctgct ggccctctgg ggacctgacc    120

cagccgcagc ctttgtgaac caacacctgt gcggctcaca cctggtggaa gctctctacc    180

tagtgtgcgg ggaacgaggc ttcttctaca cacccaagac ccgccgggag gcagaggacc    240

tgcaggtggg gcaggtggag ctgggcgggg gccctggtgc aggcagcctg cagcccttgg    300

ccctggaggg gtccctgcag aagcgtggca ttgtggaaca atgctgtacc agcatctgct    360

ccctctacca gctggagaac tactgcaact agacgcagcc cgcaggcagc cccacacccg    420

ccgcctcctg caccgagaga gatggaataa agcccttgaa ccagcaaaa                469


<210>  836
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  836

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15


Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly 
    50                  55                  60


Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 
65                  70                  75                  80


Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 
                85                  90                  95


Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105                 110


<210>  837
<211>  1817
<212>  DNA
<213>  Homo sapiens

<400>  837
cggacctcca cactgagcca tgcccacccc cgacgccacc acgccacagg ccaagggctt     60

ccgcagggcc gtgtctgagc tggacgccaa gcaggcagag gccatcatgt ccccgcggtt    120

cattgggcgc aggcagagcc tcatcgagga cgcccgcaag gagcgggagg cggcggtggc    180

agcagcggcc gctgcagtcc cctcggagcc cggggacccc ctggaggctg tggcctttga    240

ggagaaggag gggaaggccg tgctaaacct gctcttctcc ccgagggcca ccaagccctc    300

ggcgctgtcc cgagctgtga aggtgtttga gacgtttgaa gccaaaatcc accatctaga    360

gacccggccc gcccagaggc cgcgagctgg gggcccccac ctggagtact tcgtgcgcct    420

cgaggtgcgc cgaggggacc tggccgccct gctcagtggt gtgcgccagg tgtcagagga    480

cgtgcgcagc cccgcggggc ccaaggtccc ctggttccca agaaaagtgt cagagctgga    540

caagtgtcat cacctggtca ccaagttcga ccctgacctg gacttggacc acccgggctt    600

ctcggaccag gtgtaccgcc agcgcaggaa gctgattgct gagatcgcct tccagtacag    660

gcacggcgac ccgattcccc gtgtggagta caccgccgag gagattgcca cctggaagga    720

ggtctacacc acgctgaagg gcctctacgc cacgcacgcc tgcggggagc acctggaggc    780

ctttgctttg ctggagcgct tcagcggcta ccgggaagac aatatccccc agctggagga    840

cgtctcccgc ttcctgaagg agcgcacggg cttccagctg cggcctgtgg ccggcctgct    900

gtccgcccgg gacttcctgg ccagcctggc cttccgcgtg ttccagtgca cccagtatat    960

ccgccacgcg tcctcgccca tgcactcccc tgagccggac tgctgccacg agctgctggg   1020

gcacgtgccc atgctggccg accgcacctt cgcgcagttc tcgcaggaca ttggcctggc   1080

gtccctgggg gcctcggatg aggaaattga gaagctgtcc acgctgtact ggttcacggt   1140

ggagttcggg ctgtgtaagc agaacgggga ggtgaaggcc tatggtgccg ggctgctgtc   1200

ctcctacggg gagctcctgc actgcctgtc tgaggagcct gagattcggg ccttcgaccc   1260

tgaggctgcg gccgtgcagc cctaccaaga ccagacgtac cagtcagtct acttcgtgtc   1320

tgagagcttc agtgacgcca aggacaagct caggagctat gcctcacgca tccagcgccc   1380

cttctccgtg aagttcgacc cgtacacgct ggccatcgac gtgctggaca gcccccaggc   1440

cgtgcggcgc tccctggagg gtgtccagga tgagctggac acccttgccc atgcgctgag   1500

tgccattggc taggtgcacg gcgtccctga gggcccttcc caacctcccc tggtcctgca   1560

ctgtcccgga gctcaggccc tggtgagggg ctgggtcccg ggtgcccccc atgccctccc   1620

tgctgccagg ctcccactgc ccctgcacct gcttctcagc gcaacagctg tgtgtgcccg   1680

tggtgaggtt gtgctgcctg tggtgaggtc ctgtcctggc tcccagggtc ctgggggctg   1740

ctgcactgcc ctccgccctt ccctgacact gtctgctgcc ccaatcaccg tcacaataaa   1800

agaaactgtg gtctcta                                                  1817


<210>  838
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  838

Met Pro Thr Pro Asp Ala Thr Thr Pro Gln Ala Lys Gly Phe Arg Arg 
1               5                   10                  15


Ala Val Ser Glu Leu Asp Ala Lys Gln Ala Glu Ala Ile Met Ser Pro 
            20                  25                  30


Arg Phe Ile Gly Arg Arg Gln Ser Leu Ile Glu Asp Ala Arg Lys Glu 
        35                  40                  45


Arg Glu Ala Ala Val Ala Ala Ala Ala Ala Ala Val Pro Ser Glu Pro 
    50                  55                  60


Gly Asp Pro Leu Glu Ala Val Ala Phe Glu Glu Lys Glu Gly Lys Ala 
65                  70                  75                  80


Val Leu Asn Leu Leu Phe Ser Pro Arg Ala Thr Lys Pro Ser Ala Leu 
                85                  90                  95


Ser Arg Ala Val Lys Val Phe Glu Thr Phe Glu Ala Lys Ile His His 
            100                 105                 110


Leu Glu Thr Arg Pro Ala Gln Arg Pro Arg Ala Gly Gly Pro His Leu 
        115                 120                 125


Glu Tyr Phe Val Arg Leu Glu Val Arg Arg Gly Asp Leu Ala Ala Leu 
    130                 135                 140


Leu Ser Gly Val Arg Gln Val Ser Glu Asp Val Arg Ser Pro Ala Gly 
145                 150                 155                 160


Pro Lys Val Pro Trp Phe Pro Arg Lys Val Ser Glu Leu Asp Lys Cys 
                165                 170                 175


His His Leu Val Thr Lys Phe Asp Pro Asp Leu Asp Leu Asp His Pro 
            180                 185                 190


Gly Phe Ser Asp Gln Val Tyr Arg Gln Arg Arg Lys Leu Ile Ala Glu 
        195                 200                 205


Ile Ala Phe Gln Tyr Arg His Gly Asp Pro Ile Pro Arg Val Glu Tyr 
    210                 215                 220


Thr Ala Glu Glu Ile Ala Thr Trp Lys Glu Val Tyr Thr Thr Leu Lys 
225                 230                 235                 240


Gly Leu Tyr Ala Thr His Ala Cys Gly Glu His Leu Glu Ala Phe Ala 
                245                 250                 255


Leu Leu Glu Arg Phe Ser Gly Tyr Arg Glu Asp Asn Ile Pro Gln Leu 
            260                 265                 270


Glu Asp Val Ser Arg Phe Leu Lys Glu Arg Thr Gly Phe Gln Leu Arg 
        275                 280                 285


Pro Val Ala Gly Leu Leu Ser Ala Arg Asp Phe Leu Ala Ser Leu Ala 
    290                 295                 300


Phe Arg Val Phe Gln Cys Thr Gln Tyr Ile Arg His Ala Ser Ser Pro 
305                 310                 315                 320


Met His Ser Pro Glu Pro Asp Cys Cys His Glu Leu Leu Gly His Val 
                325                 330                 335


Pro Met Leu Ala Asp Arg Thr Phe Ala Gln Phe Ser Gln Asp Ile Gly 
            340                 345                 350


Leu Ala Ser Leu Gly Ala Ser Asp Glu Glu Ile Glu Lys Leu Ser Thr 
        355                 360                 365


Leu Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln Asn Gly Glu 
    370                 375                 380


Val Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Tyr Gly Glu Leu Leu 
385                 390                 395                 400


His Cys Leu Ser Glu Glu Pro Glu Ile Arg Ala Phe Asp Pro Glu Ala 
                405                 410                 415


Ala Ala Val Gln Pro Tyr Gln Asp Gln Thr Tyr Gln Ser Val Tyr Phe 
            420                 425                 430


Val Ser Glu Ser Phe Ser Asp Ala Lys Asp Lys Leu Arg Ser Tyr Ala 
        435                 440                 445


Ser Arg Ile Gln Arg Pro Phe Ser Val Lys Phe Asp Pro Tyr Thr Leu 
    450                 455                 460


Ala Ile Asp Val Leu Asp Ser Pro Gln Ala Val Arg Arg Ser Leu Glu 
465                 470                 475                 480


Gly Val Gln Asp Glu Leu Asp Thr Leu Ala His Ala Leu Ser Ala Ile 
                485                 490                 495


Gly 



<210>  839
<211>  1910
<212>  DNA
<213>  Homo sapiens

<400>  839
cggacctcca cactgagcca tgcccacccc cgacgccacc acgccacagg ccaagggctt     60

ccgcagggcc gtgtctgagc tggacgccaa gcaggcagag gccatcatgg taagagggca    120

gggcgccccg gggcccagcc tcacaggctc tccgtggcct ggaactgcag ccccagctgc    180

atcctacacc cccaccccaa ggtccccgcg gttcattggg cgcaggcaga gcctcatcga    240

ggacgcccgc aaggagcggg aggcggcggt ggcagcagcg gccgctgcag tcccctcgga    300

gcccggggac cccctggagg ctgtggcctt tgaggagaag gaggggaagg ccgtgctaaa    360

cctgctcttc tccccgaggg ccaccaagcc ctcggcgctg tcccgagctg tgaaggtgtt    420

tgagacgttt gaagccaaaa tccaccatct agagacccgg cccgcccaga ggccgcgagc    480

tgggggcccc cacctggagt acttcgtgcg cctcgaggtg cgccgagggg acctggccgc    540

cctgctcagt ggtgtgcgcc aggtgtcaga ggacgtgcgc agccccgcgg ggcccaaggt    600

cccctggttc ccaagaaaag tgtcagagct ggacaagtgt catcacctgg tcaccaagtt    660

cgaccctgac ctggacttgg accacccggg cttctcggac caggtgtacc gccagcgcag    720

gaagctgatt gctgagatcg ccttccagta caggcacggc gacccgattc cccgtgtgga    780

gtacaccgcc gaggagattg ccacctggaa ggaggtctac accacgctga agggcctcta    840

cgccacgcac gcctgcgggg agcacctgga ggcctttgct ttgctggagc gcttcagcgg    900

ctaccgggaa gacaatatcc cccagctgga ggacgtctcc cgcttcctga aggagcgcac    960

gggcttccag ctgcggcctg tggccggcct gctgtccgcc cgggacttcc tggccagcct   1020

ggccttccgc gtgttccagt gcacccagta tatccgccac gcgtcctcgc ccatgcactc   1080

ccctgagccg gactgctgcc acgagctgct ggggcacgtg cccatgctgg ccgaccgcac   1140

cttcgcgcag ttctcgcagg acattggcct ggcgtccctg ggggcctcgg atgaggaaat   1200

tgagaagctg tccacgctgt actggttcac ggtggagttc gggctgtgta agcagaacgg   1260

ggaggtgaag gcctatggtg ccgggctgct gtcctcctac ggggagctcc tgcactgcct   1320

gtctgaggag cctgagattc gggccttcga ccctgaggct gcggccgtgc agccctacca   1380

agaccagacg taccagtcag tctacttcgt gtctgagagc ttcagtgacg ccaaggacaa   1440

gctcaggagc tatgcctcac gcatccagcg ccccttctcc gtgaagttcg acccgtacac   1500

gctggccatc gacgtgctgg acagccccca ggccgtgcgg cgctccctgg agggtgtcca   1560

ggatgagctg gacacccttg cccatgcgct gagtgccatt ggctaggtgc acggcgtccc   1620

tgagggccct tcccaacctc ccctggtcct gcactgtccc ggagctcagg ccctggtgag   1680

gggctgggtc ccgggtgccc cccatgccct ccctgctgcc aggctcccac tgcccctgca   1740

cctgcttctc agcgcaacag ctgtgtgtgc ccgtggtgag gttgtgctgc ctgtggtgag   1800

gtcctgtcct ggctcccagg gtcctggggg ctgctgcact gccctccgcc cttccctgac   1860

actgtctgct gccccaatca ccgtcacaat aaaagaaact gtggtctcta              1910


<210>  840
<211>  528
<212>  PRT
<213>  Homo sapiens

<400>  840

Met Pro Thr Pro Asp Ala Thr Thr Pro Gln Ala Lys Gly Phe Arg Arg 
1               5                   10                  15


Ala Val Ser Glu Leu Asp Ala Lys Gln Ala Glu Ala Ile Met Val Arg 
            20                  25                  30


Gly Gln Gly Ala Pro Gly Pro Ser Leu Thr Gly Ser Pro Trp Pro Gly 
        35                  40                  45


Thr Ala Ala Pro Ala Ala Ser Tyr Thr Pro Thr Pro Arg Ser Pro Arg 
    50                  55                  60


Phe Ile Gly Arg Arg Gln Ser Leu Ile Glu Asp Ala Arg Lys Glu Arg 
65                  70                  75                  80


Glu Ala Ala Val Ala Ala Ala Ala Ala Ala Val Pro Ser Glu Pro Gly 
                85                  90                  95


Asp Pro Leu Glu Ala Val Ala Phe Glu Glu Lys Glu Gly Lys Ala Val 
            100                 105                 110


Leu Asn Leu Leu Phe Ser Pro Arg Ala Thr Lys Pro Ser Ala Leu Ser 
        115                 120                 125


Arg Ala Val Lys Val Phe Glu Thr Phe Glu Ala Lys Ile His His Leu 
    130                 135                 140


Glu Thr Arg Pro Ala Gln Arg Pro Arg Ala Gly Gly Pro His Leu Glu 
145                 150                 155                 160


Tyr Phe Val Arg Leu Glu Val Arg Arg Gly Asp Leu Ala Ala Leu Leu 
                165                 170                 175


Ser Gly Val Arg Gln Val Ser Glu Asp Val Arg Ser Pro Ala Gly Pro 
            180                 185                 190


Lys Val Pro Trp Phe Pro Arg Lys Val Ser Glu Leu Asp Lys Cys His 
        195                 200                 205


His Leu Val Thr Lys Phe Asp Pro Asp Leu Asp Leu Asp His Pro Gly 
    210                 215                 220


Phe Ser Asp Gln Val Tyr Arg Gln Arg Arg Lys Leu Ile Ala Glu Ile 
225                 230                 235                 240


Ala Phe Gln Tyr Arg His Gly Asp Pro Ile Pro Arg Val Glu Tyr Thr 
                245                 250                 255


Ala Glu Glu Ile Ala Thr Trp Lys Glu Val Tyr Thr Thr Leu Lys Gly 
            260                 265                 270


Leu Tyr Ala Thr His Ala Cys Gly Glu His Leu Glu Ala Phe Ala Leu 
        275                 280                 285


Leu Glu Arg Phe Ser Gly Tyr Arg Glu Asp Asn Ile Pro Gln Leu Glu 
    290                 295                 300


Asp Val Ser Arg Phe Leu Lys Glu Arg Thr Gly Phe Gln Leu Arg Pro 
305                 310                 315                 320


Val Ala Gly Leu Leu Ser Ala Arg Asp Phe Leu Ala Ser Leu Ala Phe 
                325                 330                 335


Arg Val Phe Gln Cys Thr Gln Tyr Ile Arg His Ala Ser Ser Pro Met 
            340                 345                 350


His Ser Pro Glu Pro Asp Cys Cys His Glu Leu Leu Gly His Val Pro 
        355                 360                 365


Met Leu Ala Asp Arg Thr Phe Ala Gln Phe Ser Gln Asp Ile Gly Leu 
    370                 375                 380


Ala Ser Leu Gly Ala Ser Asp Glu Glu Ile Glu Lys Leu Ser Thr Leu 
385                 390                 395                 400


Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln Asn Gly Glu Val 
                405                 410                 415


Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Tyr Gly Glu Leu Leu His 
            420                 425                 430


Cys Leu Ser Glu Glu Pro Glu Ile Arg Ala Phe Asp Pro Glu Ala Ala 
        435                 440                 445


Ala Val Gln Pro Tyr Gln Asp Gln Thr Tyr Gln Ser Val Tyr Phe Val 
    450                 455                 460


Ser Glu Ser Phe Ser Asp Ala Lys Asp Lys Leu Arg Ser Tyr Ala Ser 
465                 470                 475                 480


Arg Ile Gln Arg Pro Phe Ser Val Lys Phe Asp Pro Tyr Thr Leu Ala 
                485                 490                 495


Ile Asp Val Leu Asp Ser Pro Gln Ala Val Arg Arg Ser Leu Glu Gly 
            500                 505                 510


Val Gln Asp Glu Leu Asp Thr Leu Ala His Ala Leu Ser Ala Ile Gly 
        515                 520                 525


<210>  841
<211>  1898
<212>  DNA
<213>  Homo sapiens

<400>  841
cggacctcca cactgagcca tgcccacccc cgacgccacc acgccacagg ccaagggctt     60

ccgcagggcc gtgtctgagc tggacgccaa gcaggcagag gccatcatgg gcgccccggg    120

gcccagcctc acaggctctc cgtggcctgg aactgcagcc ccagctgcat cctacacccc    180

caccccaagg tccccgcggt tcattgggcg caggcagagc ctcatcgagg acgcccgcaa    240

ggagcgggag gcggcggtgg cagcagcggc cgctgcagtc ccctcggagc ccggggaccc    300

cctggaggct gtggcctttg aggagaagga ggggaaggcc gtgctaaacc tgctcttctc    360

cccgagggcc accaagccct cggcgctgtc ccgagctgtg aaggtgtttg agacgtttga    420

agccaaaatc caccatctag agacccggcc cgcccagagg ccgcgagctg ggggccccca    480

cctggagtac ttcgtgcgcc tcgaggtgcg ccgaggggac ctggccgccc tgctcagtgg    540

tgtgcgccag gtgtcagagg acgtgcgcag ccccgcgggg cccaaggtcc cctggttccc    600

aagaaaagtg tcagagctgg acaagtgtca tcacctggtc accaagttcg accctgacct    660

ggacttggac cacccgggct tctcggacca ggtgtaccgc cagcgcagga agctgattgc    720

tgagatcgcc ttccagtaca ggcacggcga cccgattccc cgtgtggagt acaccgccga    780

ggagattgcc acctggaagg aggtctacac cacgctgaag ggcctctacg ccacgcacgc    840

ctgcggggag cacctggagg cctttgcttt gctggagcgc ttcagcggct accgggaaga    900

caatatcccc cagctggagg acgtctcccg cttcctgaag gagcgcacgg gcttccagct    960

gcggcctgtg gccggcctgc tgtccgcccg ggacttcctg gccagcctgg ccttccgcgt   1020

gttccagtgc acccagtata tccgccacgc gtcctcgccc atgcactccc ctgagccgga   1080

ctgctgccac gagctgctgg ggcacgtgcc catgctggcc gaccgcacct tcgcgcagtt   1140

ctcgcaggac attggcctgg cgtccctggg ggcctcggat gaggaaattg agaagctgtc   1200

cacgctgtac tggttcacgg tggagttcgg gctgtgtaag cagaacgggg aggtgaaggc   1260

ctatggtgcc gggctgctgt cctcctacgg ggagctcctg cactgcctgt ctgaggagcc   1320

tgagattcgg gccttcgacc ctgaggctgc ggccgtgcag ccctaccaag accagacgta   1380

ccagtcagtc tacttcgtgt ctgagagctt cagtgacgcc aaggacaagc tcaggagcta   1440

tgcctcacgc atccagcgcc ccttctccgt gaagttcgac ccgtacacgc tggccatcga   1500

cgtgctggac agcccccagg ccgtgcggcg ctccctggag ggtgtccagg atgagctgga   1560

cacccttgcc catgcgctga gtgccattgg ctaggtgcac ggcgtccctg agggcccttc   1620

ccaacctccc ctggtcctgc actgtcccgg agctcaggcc ctggtgaggg gctgggtccc   1680

gggtgccccc catgccctcc ctgctgccag gctcccactg cccctgcacc tgcttctcag   1740

cgcaacagct gtgtgtgccc gtggtgaggt tgtgctgcct gtggtgaggt cctgtcctgg   1800

ctcccagggt cctgggggct gctgcactgc cctccgccct tccctgacac tgtctgctgc   1860

cccaatcacc gtcacaataa aagaaactgt ggtctcta                           1898


<210>  842
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  842

Met Pro Thr Pro Asp Ala Thr Thr Pro Gln Ala Lys Gly Phe Arg Arg 
1               5                   10                  15


Ala Val Ser Glu Leu Asp Ala Lys Gln Ala Glu Ala Ile Met Gly Ala 
            20                  25                  30


Pro Gly Pro Ser Leu Thr Gly Ser Pro Trp Pro Gly Thr Ala Ala Pro 
        35                  40                  45


Ala Ala Ser Tyr Thr Pro Thr Pro Arg Ser Pro Arg Phe Ile Gly Arg 
    50                  55                  60


Arg Gln Ser Leu Ile Glu Asp Ala Arg Lys Glu Arg Glu Ala Ala Val 
65                  70                  75                  80


Ala Ala Ala Ala Ala Ala Val Pro Ser Glu Pro Gly Asp Pro Leu Glu 
                85                  90                  95


Ala Val Ala Phe Glu Glu Lys Glu Gly Lys Ala Val Leu Asn Leu Leu 
            100                 105                 110


Phe Ser Pro Arg Ala Thr Lys Pro Ser Ala Leu Ser Arg Ala Val Lys 
        115                 120                 125


Val Phe Glu Thr Phe Glu Ala Lys Ile His His Leu Glu Thr Arg Pro 
    130                 135                 140


Ala Gln Arg Pro Arg Ala Gly Gly Pro His Leu Glu Tyr Phe Val Arg 
145                 150                 155                 160


Leu Glu Val Arg Arg Gly Asp Leu Ala Ala Leu Leu Ser Gly Val Arg 
                165                 170                 175


Gln Val Ser Glu Asp Val Arg Ser Pro Ala Gly Pro Lys Val Pro Trp 
            180                 185                 190


Phe Pro Arg Lys Val Ser Glu Leu Asp Lys Cys His His Leu Val Thr 
        195                 200                 205


Lys Phe Asp Pro Asp Leu Asp Leu Asp His Pro Gly Phe Ser Asp Gln 
    210                 215                 220


Val Tyr Arg Gln Arg Arg Lys Leu Ile Ala Glu Ile Ala Phe Gln Tyr 
225                 230                 235                 240


Arg His Gly Asp Pro Ile Pro Arg Val Glu Tyr Thr Ala Glu Glu Ile 
                245                 250                 255


Ala Thr Trp Lys Glu Val Tyr Thr Thr Leu Lys Gly Leu Tyr Ala Thr 
            260                 265                 270


His Ala Cys Gly Glu His Leu Glu Ala Phe Ala Leu Leu Glu Arg Phe 
        275                 280                 285


Ser Gly Tyr Arg Glu Asp Asn Ile Pro Gln Leu Glu Asp Val Ser Arg 
    290                 295                 300


Phe Leu Lys Glu Arg Thr Gly Phe Gln Leu Arg Pro Val Ala Gly Leu 
305                 310                 315                 320


Leu Ser Ala Arg Asp Phe Leu Ala Ser Leu Ala Phe Arg Val Phe Gln 
                325                 330                 335


Cys Thr Gln Tyr Ile Arg His Ala Ser Ser Pro Met His Ser Pro Glu 
            340                 345                 350


Pro Asp Cys Cys His Glu Leu Leu Gly His Val Pro Met Leu Ala Asp 
        355                 360                 365


Arg Thr Phe Ala Gln Phe Ser Gln Asp Ile Gly Leu Ala Ser Leu Gly 
    370                 375                 380


Ala Ser Asp Glu Glu Ile Glu Lys Leu Ser Thr Leu Tyr Trp Phe Thr 
385                 390                 395                 400


Val Glu Phe Gly Leu Cys Lys Gln Asn Gly Glu Val Lys Ala Tyr Gly 
                405                 410                 415


Ala Gly Leu Leu Ser Ser Tyr Gly Glu Leu Leu His Cys Leu Ser Glu 
            420                 425                 430


Glu Pro Glu Ile Arg Ala Phe Asp Pro Glu Ala Ala Ala Val Gln Pro 
        435                 440                 445


Tyr Gln Asp Gln Thr Tyr Gln Ser Val Tyr Phe Val Ser Glu Ser Phe 
    450                 455                 460


Ser Asp Ala Lys Asp Lys Leu Arg Ser Tyr Ala Ser Arg Ile Gln Arg 
465                 470                 475                 480


Pro Phe Ser Val Lys Phe Asp Pro Tyr Thr Leu Ala Ile Asp Val Leu 
                485                 490                 495


Asp Ser Pro Gln Ala Val Arg Arg Ser Leu Glu Gly Val Gln Asp Glu 
            500                 505                 510


Leu Asp Thr Leu Ala His Ala Leu Ser Ala Ile Gly 
        515                 520


<210>  843
<211>  2347
<212>  DNA
<213>  Homo sapiens

<400>  843
gggaggtttg gagccctgca taaagagaag gacgggacca cagctgactg ctgtgtcccc     60

acagatctgg gcctcctgct gccaccatgg ccaaaggtgg agaagccctg ccacagggca    120

gcccagcacc agtccaggat ccccacctca tcaaggtgac agtgaagacg cccaaagaca    180

aggaggattt ctcagttaca gacacatgca ctatccagca gctgaaggaa gagatatctc    240

agcgctttaa ggcccacccc gatcagcttg ttctaatctt tgctggcaaa atcctcaagg    300

atcctgactc actggcacag tgtggagtgc gagatggcct cactgtccac ctggtcatca    360

agaggcagca ccgtgccatg ggcaatgagt gcccagctgc ctctgtccct acccagggcc    420

caagtcctgg atcactccct cagccaagct ccatttaccc agcagatggg ccccctgcct    480

ttagcttagg tctcctcaca ggcctcagta ggctgggctt ggcctatcgt ggcttccctg    540

accagccaag ctccctgatg cggcagcatg tgtctgtgcc tgagtttgtg actcagctca    600

ttgatgaccc cttcatcccg ggtctgctgt ccaacacagg cctagtacgc cagctggttc    660

ttgacaaccc ccatatgcag cagctgatcc agcacaaccc tgagattggg catattctta    720

acaacccgga aattatgcgg cagacactgg agtttttacg taaccctgcc atgatgcagg    780

agatgatacg tagccaggac cgggtgctca gtaacttgga gagcattcct ggtggctaca    840

atgtgctttg cactatgtac acagatatta tggacccaat gcttaacgca gtccaggagc    900

agtttggcgg caatcccttt gccactgcca ctactgataa tgccaccacc accaccagcc    960

aaccttcaag gatggagaat tgtgaccctc tccccaaccc ctggacttcc acacatggag   1020

gctcaggtag caggcaagga aggcaggatg gggatcagga tgcacctgac attagaaata   1080

ggtttccaaa ctttctgggt attataaggc tctatgacta tctccagcaa ttacacgaga   1140

acccccagtc cctaggaact tatctacagg ggactgcatc tgccctcagc caaagccagg   1200

aaccaccacc atcagtaaac agagttcccc catcgtcacc ctcatctcag gagcctgggt   1260

caggccagcc tctccccgag gagtcagtag caatcaaggg aaggtcctcc tgcccagctt   1320

tcctgagata ccccacagag aacagtactg gacaaggtgg agaccaagat ggtgcaggga   1380

aaagctctac tggacatagc acaaacttgc ctgatcttgt ctcggggctg ggagattctg   1440

ccaacagggt tccatttgct cccttatctt tttcccccac ggcagccatt cctggaatcc   1500

ctgagcctcc ctggctgcca tccccggctt atccaagatc tctgaggcca gatggcatga   1560

atccagctcc acagttacag gatgagatac aaccacagct gccactgctg atgcaccttc   1620

aggcagccat ggcaaacccc cgtgccctgc aagccctgcg gcagattgag cagggtctac   1680

aggtcctagc tactgaagca cctcgcctcc tactctggtt catgccttgc ctagcaggga   1740

cgggtagtgt ggcaggaggt atagagtcta gagaagatcc ccttatgtct gaggatcctc   1800

tcccaaatcc acctcctgag gtgttcccag cactggactc tgcagagctg ggcttccttt   1860

cccctccctt tctccatatg ctgcaagatt tagttagtac aaatccccag cagctgcagc   1920

ctgaggctca ctttcaggtg cagctggagc aactgcggtc catgggcttt ctgaatcgtg   1980

aagccaatct tcaggccctc attgctacgg ggggcgacgt ggatgctgct gtggagaagc   2040

tgagacagtc gtaggagcct tattcattca aaccatacgt tttcctctgt gcctttttcc   2100

catatcctag ttccctagct ctcccatttt tgaatacagc tgcattataa accaaattta   2160

ctatgaagtc ctttgctgtg gaggcaatgt tgttccagag tcaacgagga agactaatgg   2220

ccaaaacata gtggaggtgc tgtgtgtgag tcaaccactt gtaccactat accactgggg   2280

ggccccagtc taagctctgc ttatgcctat cttgagatgc aattacaccc aatttccaat   2340

gtgaaaa                                                             2347


<210>  844
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  844

Met Ala Lys Gly Gly Glu Ala Leu Pro Gln Gly Ser Pro Ala Pro Val 
1               5                   10                  15


Gln Asp Pro His Leu Ile Lys Val Thr Val Lys Thr Pro Lys Asp Lys 
            20                  25                  30


Glu Asp Phe Ser Val Thr Asp Thr Cys Thr Ile Gln Gln Leu Lys Glu 
        35                  40                  45


Glu Ile Ser Gln Arg Phe Lys Ala His Pro Asp Gln Leu Val Leu Ile 
    50                  55                  60


Phe Ala Gly Lys Ile Leu Lys Asp Pro Asp Ser Leu Ala Gln Cys Gly 
65                  70                  75                  80


Val Arg Asp Gly Leu Thr Val His Leu Val Ile Lys Arg Gln His Arg 
                85                  90                  95


Ala Met Gly Asn Glu Cys Pro Ala Ala Ser Val Pro Thr Gln Gly Pro 
            100                 105                 110


Ser Pro Gly Ser Leu Pro Gln Pro Ser Ser Ile Tyr Pro Ala Asp Gly 
        115                 120                 125


Pro Pro Ala Phe Ser Leu Gly Leu Leu Thr Gly Leu Ser Arg Leu Gly 
    130                 135                 140


Leu Ala Tyr Arg Gly Phe Pro Asp Gln Pro Ser Ser Leu Met Arg Gln 
145                 150                 155                 160


His Val Ser Val Pro Glu Phe Val Thr Gln Leu Ile Asp Asp Pro Phe 
                165                 170                 175


Ile Pro Gly Leu Leu Ser Asn Thr Gly Leu Val Arg Gln Leu Val Leu 
            180                 185                 190


Asp Asn Pro His Met Gln Gln Leu Ile Gln His Asn Pro Glu Ile Gly 
        195                 200                 205


His Ile Leu Asn Asn Pro Glu Ile Met Arg Gln Thr Leu Glu Phe Leu 
    210                 215                 220


Arg Asn Pro Ala Met Met Gln Glu Met Ile Arg Ser Gln Asp Arg Val 
225                 230                 235                 240


Leu Ser Asn Leu Glu Ser Ile Pro Gly Gly Tyr Asn Val Leu Cys Thr 
                245                 250                 255


Met Tyr Thr Asp Ile Met Asp Pro Met Leu Asn Ala Val Gln Glu Gln 
            260                 265                 270


Phe Gly Gly Asn Pro Phe Ala Thr Ala Thr Thr Asp Asn Ala Thr Thr 
        275                 280                 285


Thr Thr Ser Gln Pro Ser Arg Met Glu Asn Cys Asp Pro Leu Pro Asn 
    290                 295                 300


Pro Trp Thr Ser Thr His Gly Gly Ser Gly Ser Arg Gln Gly Arg Gln 
305                 310                 315                 320


Asp Gly Asp Gln Asp Ala Pro Asp Ile Arg Asn Arg Phe Pro Asn Phe 
                325                 330                 335


Leu Gly Ile Ile Arg Leu Tyr Asp Tyr Leu Gln Gln Leu His Glu Asn 
            340                 345                 350


Pro Gln Ser Leu Gly Thr Tyr Leu Gln Gly Thr Ala Ser Ala Leu Ser 
        355                 360                 365


Gln Ser Gln Glu Pro Pro Pro Ser Val Asn Arg Val Pro Pro Ser Ser 
    370                 375                 380


Pro Ser Ser Gln Glu Pro Gly Ser Gly Gln Pro Leu Pro Glu Glu Ser 
385                 390                 395                 400


Val Ala Ile Lys Gly Arg Ser Ser Cys Pro Ala Phe Leu Arg Tyr Pro 
                405                 410                 415


Thr Glu Asn Ser Thr Gly Gln Gly Gly Asp Gln Asp Gly Ala Gly Lys 
            420                 425                 430


Ser Ser Thr Gly His Ser Thr Asn Leu Pro Asp Leu Val Ser Gly Leu 
        435                 440                 445


Gly Asp Ser Ala Asn Arg Val Pro Phe Ala Pro Leu Ser Phe Ser Pro 
    450                 455                 460


Thr Ala Ala Ile Pro Gly Ile Pro Glu Pro Pro Trp Leu Pro Ser Pro 
465                 470                 475                 480


Ala Tyr Pro Arg Ser Leu Arg Pro Asp Gly Met Asn Pro Ala Pro Gln 
                485                 490                 495


Leu Gln Asp Glu Ile Gln Pro Gln Leu Pro Leu Leu Met His Leu Gln 
            500                 505                 510


Ala Ala Met Ala Asn Pro Arg Ala Leu Gln Ala Leu Arg Gln Ile Glu 
        515                 520                 525


Gln Gly Leu Gln Val Leu Ala Thr Glu Ala Pro Arg Leu Leu Leu Trp 
    530                 535                 540


Phe Met Pro Cys Leu Ala Gly Thr Gly Ser Val Ala Gly Gly Ile Glu 
545                 550                 555                 560


Ser Arg Glu Asp Pro Leu Met Ser Glu Asp Pro Leu Pro Asn Pro Pro 
                565                 570                 575


Pro Glu Val Phe Pro Ala Leu Asp Ser Ala Glu Leu Gly Phe Leu Ser 
            580                 585                 590


Pro Pro Phe Leu His Met Leu Gln Asp Leu Val Ser Thr Asn Pro Gln 
        595                 600                 605


Gln Leu Gln Pro Glu Ala His Phe Gln Val Gln Leu Glu Gln Leu Arg 
    610                 615                 620


Ser Met Gly Phe Leu Asn Arg Glu Ala Asn Leu Gln Ala Leu Ile Ala 
625                 630                 635                 640


Thr Gly Gly Asp Val Asp Ala Ala Val Glu Lys Leu Arg Gln Ser 
                645                 650                 655


<210>  845
<211>  2350
<212>  DNA
<213>  Homo sapiens

<400>  845
agccctagga gaagtcatca ccactttgtc caccatgggt gaattatgaa tcagtagcta     60

tgccaggcct cagctgggcc acatctggag aactggggtg agggcacaac atcacaaaat    120

atctggcccc agtctggtca ctcatccctt ttagggcaac aaggaaacta tcctgtggcc    180

tgagagcaca atacctgaga caaaggccag cagaaacatt tgtctgccct caccctttct    240

gccccagctt ccacctgctc cccatctgcc cacccactaa agcccatgtg gcatgccatc    300

tctcgaacat ccaggatgtc ccagagtgga tgtccatcag gtctgctggc agacaaaaat    360

atctcttcaa gtgccactcg agtgatagtg aagactgcag gcaaccagaa agactttatg    420

gtagctgatg acatctcggt aaggcagttc aaggagatgc tattggctca cttccaatgc    480

cagatggacc aactagtgct ggtcttcatg ggttgccttc tcaaagacca tgacacactg    540

agccagaggg gcatcatgga tggccacacc atctacttgg tcatcaagtc caagcagggc    600

tccagatctc tagcccattc cttccgggac ctgccaacga atgatccctg ccaccgggac    660

agaaacacca aaggaaacag cagcagagtg caccaaccaa ctggtatgaa tcaagctcca    720

gtggaactgg cccactttgt ggggtctgat gcacccaaag tgcataccca aaacttggaa    780

gtgagccacc cagagtgcaa agcacagatg ctggagaatc ctagcatcca gcggcttctg    840

tccaacatgg agttcatgtg gcagttcatt tcagaacatc tagacacgca acaattgatg    900

cagcagaacc cagaagtttc ccgccttctt cttgataatt ctgagatcct attgcagact    960

ctggagctgg ccaggaacct tgctatgatc caagagataa tgcagatcca acaaccttca   1020

caaaaccttg agtatccact gaacccacag ccatatctgg gcttagagac aatgccaggt   1080

gggaataatg ccctgggtca gaactatgct gatatcaatg atcaaatgct gaacagcatg   1140

caagatcctt ttggaggaaa ccctttcaca gctctcctgg caggacaagt gctagaacaa   1200

gtccagtctt cacccccacc tccaccacca tcacaggaac aacaagacca gctcacacag   1260

catcctgcaa cccgagtcat ctataatagc tctggtggtt tctcttcaaa cacctcagcc   1320

aatgacaccc ttaacaaggt caaccacact tccaaagcca acactgctat gatttccacc   1380

aagggccaga gccatatctg tgccactcgg cagccagctt ggataccagc cttacctagc   1440

atagagctta cccagcagct tcaagaagaa tacaaggatg ccactgtttc tctaagtagc   1500

tccagacaga cattaaaggg tgatctccag ctgtcagatg agcagagcag ctcccagatc   1560

acaggaggca tgatgcagtt gcttatgaac aacccctacc tggcagctca gattatgttg   1620

ttcacaagta tgccccagct gagtgaacag tggaggcagc agctgcccac attcctgcag   1680

cagacacaga tttctgatct gcttagtgct taggcaaccc taaagcattc caagcaatat   1740

tgcagattga gcaggccctc cagctgctgg ccacagaggc tcctgttctt ctgccttggg   1800

ttgcacccta cctatggggc ctgggttggc ttcctgcccc cagctgcagc tatcctgaca   1860

cagtgccctg ttcctggaat gtttcagata cagctgagcc caagggacct gagtgctgcc   1920

acaagcctgg aacagtcctg cagaggctac aatccccgga tggggaccct tcccaccctc   1980

tgcaagctcc tgagatttgt tttagcaaac agatggattc tctccaggcc atgggatttg   2040

ggaaccacca tgccaatcta caggcactca ttgctactga aggggacacc aatgctgcta   2100

tccgcaagct caagagatcc cagagattct aaccaccatg cctacttgtt tgcttgctac   2160

ctgcctgctg acccacctga ccatctcatt tgccttttgc acctttcctg atgcttccag   2220

ccaggagaag tcctggaata agagttatca accaatgtgt cttgtactga ataatagatc   2280

attggtcgtg gctgaaacat ctgtcaataa aatggctaca ctcacttgct gcgaaaaaaa   2340

aaaaaaaaaa                                                          2350


<210>  846
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  846

Met Trp His Ala Ile Ser Arg Thr Ser Arg Met Ser Gln Ser Gly Cys 
1               5                   10                  15


Pro Ser Gly Leu Leu Ala Asp Lys Asn Ile Ser Ser Ser Ala Thr Arg 
            20                  25                  30


Val Ile Val Lys Thr Ala Gly Asn Gln Lys Asp Phe Met Val Ala Asp 
        35                  40                  45


Asp Ile Ser Val Arg Gln Phe Lys Glu Met Leu Leu Ala His Phe Gln 
    50                  55                  60


Cys Gln Met Asp Gln Leu Val Leu Val Phe Met Gly Cys Leu Leu Lys 
65                  70                  75                  80


Asp His Asp Thr Leu Ser Gln Arg Gly Ile Met Asp Gly His Thr Ile 
                85                  90                  95


Tyr Leu Val Ile Lys Ser Lys Gln Gly Ser Arg Ser Leu Ala His Ser 
            100                 105                 110


Phe Arg Asp Leu Pro Thr Asn Asp Pro Cys His Arg Asp Arg Asn Thr 
        115                 120                 125


Lys Gly Asn Ser Ser Arg Val His Gln Pro Thr Gly Met Asn Gln Ala 
    130                 135                 140


Pro Val Glu Leu Ala His Phe Val Gly Ser Asp Ala Pro Lys Val His 
145                 150                 155                 160


Thr Gln Asn Leu Glu Val Ser His Pro Glu Cys Lys Ala Gln Met Leu 
                165                 170                 175


Glu Asn Pro Ser Ile Gln Arg Leu Leu Ser Asn Met Glu Phe Met Trp 
            180                 185                 190


Gln Phe Ile Ser Glu His Leu Asp Thr Gln Gln Leu Met Gln Gln Asn 
        195                 200                 205


Pro Glu Val Ser Arg Leu Leu Leu Asp Asn Ser Glu Ile Leu Leu Gln 
    210                 215                 220


Thr Leu Glu Leu Ala Arg Asn Leu Ala Met Ile Gln Glu Ile Met Gln 
225                 230                 235                 240


Ile Gln Gln Pro Ser Gln Asn Leu Glu Tyr Pro Leu Asn Pro Gln Pro 
                245                 250                 255


Tyr Leu Gly Leu Glu Thr Met Pro Gly Gly Asn Asn Ala Leu Gly Gln 
            260                 265                 270


Asn Tyr Ala Asp Ile Asn Asp Gln Met Leu Asn Ser Met Gln Asp Pro 
        275                 280                 285


Phe Gly Gly Asn Pro Phe Thr Ala Leu Leu Ala Gly Gln Val Leu Glu 
    290                 295                 300


Gln Val Gln Ser Ser Pro Pro Pro Pro Pro Pro Ser Gln Glu Gln Gln 
305                 310                 315                 320


Asp Gln Leu Thr Gln His Pro Ala Thr Arg Val Ile Tyr Asn Ser Ser 
                325                 330                 335


Gly Gly Phe Ser Ser Asn Thr Ser Ala Asn Asp Thr Leu Asn Lys Val 
            340                 345                 350


Asn His Thr Ser Lys Ala Asn Thr Ala Met Ile Ser Thr Lys Gly Gln 
        355                 360                 365


Ser His Ile Cys Ala Thr Arg Gln Pro Ala Trp Ile Pro Ala Leu Pro 
    370                 375                 380


Ser Ile Glu Leu Thr Gln Gln Leu Gln Glu Glu Tyr Lys Asp Ala Thr 
385                 390                 395                 400


Val Ser Leu Ser Ser Ser Arg Gln Thr Leu Lys Gly Asp Leu Gln Leu 
                405                 410                 415


Ser Asp Glu Gln Ser Ser Ser Gln Ile Thr Gly Gly Met Met Gln Leu 
            420                 425                 430


Leu Met Asn Asn Pro Tyr Leu Ala Ala Gln Ile Met Leu Phe Thr Ser 
        435                 440                 445


Met Pro Gln Leu Ser Glu Gln Trp Arg Gln Gln Leu Pro Thr Phe Leu 
    450                 455                 460


Gln Gln Thr Gln Ile Ser Asp Leu Leu Ser Ala 
465                 470                 475


<210>  847
<211>  1473
<212>  DNA
<213>  Homo sapiens

<400>  847
atgcttcatt atgtttactg tgcctgtggc catggtttgc agctggtgag aagtgtgtca     60

agctctgtgg atgaaggagg cacatgccat tgtatggttc acctacccaa caaccccatc    120

cccctggagc agctggaaca gctacaaagt acagctcagg agctcatttg caagtatgag    180

cagaagctgt ctagagtgaa aaattgtgca cgcgccattg aagataaaga caatgaggtt    240

ctggaaatga gtcacatgct gaagtcctgg aatcccagtg cccttgcttc tccctatgag    300

aacccaggct tcaacctgct gtgcctggag ctggagggag cacaggagtt ggtgactcaa    360

cttaaagcca tgggaggtgt tagtgtggct ggggacctcc tccaccaact tcagagccag    420

gtgactaacg ccagtctcac actcaaactt ttggctgact ctgaccagtg cagctttggt    480

gctctccagc aggaggtgga tgtccttgag agtcaactaa gtgaatgtga gagagaaaag    540

gagaaagaat aggcctttgg acaccctgga ccacccctcc ccccggtgac ttcttgtgcc    600

catggaggcc tccaggaagt tagcaaatcc cttgtggtgc agctcactcg gagaggcttc    660

tcatataagg caggtccctg gggccgagac tcagcaccca atccagcctc ttccctttac    720

tgggttgctc ctctacgtac agatggcagg tactttgact actatcggct gtgcaaatcc    780

tataatgacc tcgcactgct gaaaaactat gaagagagga agatgggcta tggtgatggc    840

agtggaaacg ttgtgtacaa gaactttatg tactttaact actgtggcac aagtgacatg    900

gccaaaatgg acctttcctc caacacactg gtgctgtggc gtctgctgcc tggtgccacc    960

tataacaacc gcttttccta tgctggtgtg ccctggaagg acttagattt tgctggtgat   1020

gagaaggggc tgtgggttct ctatgccact gaggagagca agggcaacct ggttgtgagt   1080

cgtctcaacg ctagcaccct agaagtggag aaaacctggc gtaccagcca gtacaagcca   1140

gccctgtcag gggccttcat ggcctgtggg gtgctctatg ccttacattc actgaacacc   1200

caccaagagg agatcttcta tgcttttgac accaccaccg ggcaggagcg ccgcctcagc   1260

atcctgttgg acaagatgct ggaaaagctg cagggcatca actactgccc ctcagaccac   1320

aagccgtatg tcttcagtga tggttacctg ataaattatg acctcacctt cctgacaatg   1380

aagaccaggc taccaagacc acccaccagg aggccctctg gggctcatgc tccaccaaaa   1440

cctgtcaaac ctaacgaggc ttccagaccc tga                                1473


<210>  848
<211>  963
<212>  DNA
<213>  Homo sapiens

<400>  848
atgccatctg cctctgccat gatcattttc aacctgagca gttacaatcc aggacccttc     60

attctggtag ggatcccagg cctggagcaa ttccatgtgt ggattggaat tcccttctgt    120

atcatctaca ttgtagctgt tgtgggaaac tgcatccttc tctacctcat tgtggtggag    180

catagtcttc atgaacccat gttcttcttt ctctccatgc tggccatgac tgacctcatc    240

ttgtccacag ctggtgtgcc taaagcactc agtatctttt ggctaggggc tcgcgaaatc    300

acattcccag gatgccttac acaaatgttc ttccttcact ataactttgt cctggattca    360

gccattctga tggccatggc atttgatcac tatgtagcta tctgttctcc cttgagatat    420

accaccatct tgactcccaa gaccatcatc aagagtgcta tgggcatctc ctttcgaagc    480

ttctgcatca tcctgccaga tgtattcttg ctgacatgcc tgcctttctg caggacacgc    540

atcatacccc acacatactg tgagcatata ggtgttgccc agctcgcctg tgctgatatc    600

tccatcaact tctggtatgg cttttgtgtt cccatcatga cggtcatctc agatgtgatt    660

ctcattgctg tttcctacgc acacatcctc tgtgctgtct ttggccttcc ctcccaagat    720

gcctgccaga aagccctcgg cacttgtggt tctcatgtct gtgtcatcct catgttttat    780

acacctgcct ttttctccat cctcgcccat cgctttggac acaatgtctc tcgcaccttc    840

cacatcatgt ttgccaatct ctacattgtt atcccacctg cactcaaccc catggtttac    900

ggagtgaaga ccaagcagat cagagataag gttatacttt tgttttctaa gggtacagga    960

tga                                                                  963


<210>  849
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  849

Met Pro Ser Ala Ser Ala Met Ile Ile Phe Asn Leu Ser Ser Tyr Asn 
1               5                   10                  15


Pro Gly Pro Phe Ile Leu Val Gly Ile Pro Gly Leu Glu Gln Phe His 
            20                  25                  30


Val Trp Ile Gly Ile Pro Phe Cys Ile Ile Tyr Ile Val Ala Val Val 
        35                  40                  45


Gly Asn Cys Ile Leu Leu Tyr Leu Ile Val Val Glu His Ser Leu His 
    50                  55                  60


Glu Pro Met Phe Phe Phe Leu Ser Met Leu Ala Met Thr Asp Leu Ile 
65                  70                  75                  80


Leu Ser Thr Ala Gly Val Pro Lys Ala Leu Ser Ile Phe Trp Leu Gly 
                85                  90                  95


Ala Arg Glu Ile Thr Phe Pro Gly Cys Leu Thr Gln Met Phe Phe Leu 
            100                 105                 110


His Tyr Asn Phe Val Leu Asp Ser Ala Ile Leu Met Ala Met Ala Phe 
        115                 120                 125


Asp His Tyr Val Ala Ile Cys Ser Pro Leu Arg Tyr Thr Thr Ile Leu 
    130                 135                 140


Thr Pro Lys Thr Ile Ile Lys Ser Ala Met Gly Ile Ser Phe Arg Ser 
145                 150                 155                 160


Phe Cys Ile Ile Leu Pro Asp Val Phe Leu Leu Thr Cys Leu Pro Phe 
                165                 170                 175


Cys Arg Thr Arg Ile Ile Pro His Thr Tyr Cys Glu His Ile Gly Val 
            180                 185                 190


Ala Gln Leu Ala Cys Ala Asp Ile Ser Ile Asn Phe Trp Tyr Gly Phe 
        195                 200                 205


Cys Val Pro Ile Met Thr Val Ile Ser Asp Val Ile Leu Ile Ala Val 
    210                 215                 220


Ser Tyr Ala His Ile Leu Cys Ala Val Phe Gly Leu Pro Ser Gln Asp 
225                 230                 235                 240


Ala Cys Gln Lys Ala Leu Gly Thr Cys Gly Ser His Val Cys Val Ile 
                245                 250                 255


Leu Met Phe Tyr Thr Pro Ala Phe Phe Ser Ile Leu Ala His Arg Phe 
            260                 265                 270


Gly His Asn Val Ser Arg Thr Phe His Ile Met Phe Ala Asn Leu Tyr 
        275                 280                 285


Ile Val Ile Pro Pro Ala Leu Asn Pro Met Val Tyr Gly Val Lys Thr 
    290                 295                 300


Lys Gln Ile Arg Asp Lys Val Ile Leu Leu Phe Ser Lys Gly Thr Gly 
305                 310                 315                 320


<210>  850
<211>  1259
<212>  DNA
<213>  Homo sapiens

<400>  850
atgtctaagt cagagtctcc taaagagcct gaacagctga ggaaactgtt cattggaggg     60

ttgagctttg aaacaaccga tgagaggctg aggaaggagc cattttgagc aatgggaaca    120

ctcatggatt gtgtggtaat gagagaccca aacaccaagt gctccagggg ctttgggttt    180

gtcacatatg ccactgtgga ggaggtggat gcagccatga atgcaaggcc acacacggtg    240

gatggaagag tcgtggaacc aaagagagct gtctcaagag aagattctca aagacccact    300

taactgtgaa aaagttattt gttggtggca ttaaagaaga cactgaagaa catcacctaa    360

gagattattt tgaccagtat ggaaaaattg aagtgattga ctgaggcatt ggcaagaaaa    420

ggggctttgc ctttgtaacc tttgacaacc atgactctgt ggataagatt gtcattcaga    480

aataccacac tgtgaatggc cacaactgtg aagttaggaa agccctgtga aagcaagaga    540

tggctagtgc ttcagccagc caaagaggtc aaagtggttc tggaaacttt gatggtggta    600

tggaggtggt ttcggtggga atgacaactt tggtcatgga ggaaacttca gtggttgtgg    660

tggctttggt ggcaaccatg gtgctggtgg atatggtggc agtggggatg gctataacgg    720

atttggtaat aatgaaagca attttggagg tggtggaagc tacagtgatt ttggcaatta    780

caacaatcag tcttcaaatt tcagacccat gaagggagga aactttggag gcagaagccc    840

tggcccctat ggtggtggag gccaatattt tgccaaacct cgaaactaaa gtggctatgg    900

tggttctagt agtagcagta gctatggcag tggcagaaga ttttaattag gaaacaaagc    960

ttatcaggag aagagagcaa gagaagtgac agggaagcta caggttacaa tagatttgtg   1020

aactcagcca agcacagtgg tggcagggcc tagctgctac aaagaagaca tgttttagac   1080

aaatactcat gtttatgggc aaaaaactcg aggactgtat ttgtgactaa ttgtataaca   1140

ggttatttta gtttctgttc tgcggaaagt gtaaagcatt ccaacaaagg gttatagtgt   1200

agatttttaa ctttttttgc acctatgctg ttgaattcta aatgtaatag tctgattgt    1259


<210>  851
<211>  1008
<212>  DNA
<213>  Homo sapiens

<400>  851
atggcacagg tgagggcgct gcataaaatc atggcccttt tttctgctaa cagcataggt     60

gctatgaaca actctgacac tcgcatagca ggctgcttcc tcactggcat ccctgggctg    120

gagcaactac atatctggct gtccatcccc ttctgcatca tgtacatcac tgccctggaa    180

ggcaatggca tcctaatttg tgtcatcctc tcccaggcaa tcctgcatga gcccatgtac    240

atattcttat ctatgctggc cagtgctgat gtcttgctct ctaccaccac catgcctaag    300

gccctggcca atttgtggct aggttatagc ctcatttcct ttgatggctg cctcactcag    360

atgttcttca ttcacttcct cttcattcac tctgctgtcc tgctggccat ggcctttgac    420

cgctatgtgg ccatctgctc ccccctgcga tatgtcacaa tcctcacaag caaggtcatt    480

gggaagatcg tcactgccgc cctgagccac agcttcatca ttatgtttcc atccatcttt    540

ctccttgagc acctgcacta ttgccagatc aatatcattg cacacacatt ttgtgagcac    600

atgggcattg cccatctgtc ctgttctgat atctccatca atgtctggta tgggttggca    660

gctgctcttc tctccacagg cctagacatc atgcttatta ctgtttccta catccacatc    720

ctccaagcag tcttccgcct cctttctcaa gatgcccgct ccaaggccct gagtacctgt    780

ggatcccata tctgtgtcat cctactcttc tatgtccctg cgcttttttc tgtctttgcc    840

tacaggtttg gtgggagaag cgtcccatgc tatgtccata ttctcctggc cagcctctac    900

gttgtcattc ctcctatgct caatcccgtt atttatggag tgaggactaa gccaatactg    960

gaaggggcta agcagatgtt ttcaaatctt gccaaaggat ctaaataa                1008


<210>  852
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  852

Met Ala Gln Val Arg Ala Leu His Lys Ile Met Ala Leu Phe Ser Ala 
1               5                   10                  15


Asn Ser Ile Gly Ala Met Asn Asn Ser Asp Thr Arg Ile Ala Gly Cys 
            20                  25                  30


Phe Leu Thr Gly Ile Pro Gly Leu Glu Gln Leu His Ile Trp Leu Ser 
        35                  40                  45


Ile Pro Phe Cys Ile Met Tyr Ile Thr Ala Leu Glu Gly Asn Gly Ile 
    50                  55                  60


Leu Ile Cys Val Ile Leu Ser Gln Ala Ile Leu His Glu Pro Met Tyr 
65                  70                  75                  80


Ile Phe Leu Ser Met Leu Ala Ser Ala Asp Val Leu Leu Ser Thr Thr 
                85                  90                  95


Thr Met Pro Lys Ala Leu Ala Asn Leu Trp Leu Gly Tyr Ser Leu Ile 
            100                 105                 110


Ser Phe Asp Gly Cys Leu Thr Gln Met Phe Phe Ile His Phe Leu Phe 
        115                 120                 125


Ile His Ser Ala Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala 
    130                 135                 140


Ile Cys Ser Pro Leu Arg Tyr Val Thr Ile Leu Thr Ser Lys Val Ile 
145                 150                 155                 160


Gly Lys Ile Val Thr Ala Ala Leu Ser His Ser Phe Ile Ile Met Phe 
                165                 170                 175


Pro Ser Ile Phe Leu Leu Glu His Leu His Tyr Cys Gln Ile Asn Ile 
            180                 185                 190


Ile Ala His Thr Phe Cys Glu His Met Gly Ile Ala His Leu Ser Cys 
        195                 200                 205


Ser Asp Ile Ser Ile Asn Val Trp Tyr Gly Leu Ala Ala Ala Leu Leu 
    210                 215                 220


Ser Thr Gly Leu Asp Ile Met Leu Ile Thr Val Ser Tyr Ile His Ile 
225                 230                 235                 240


Leu Gln Ala Val Phe Arg Leu Leu Ser Gln Asp Ala Arg Ser Lys Ala 
                245                 250                 255


Leu Ser Thr Cys Gly Ser His Ile Cys Val Ile Leu Leu Phe Tyr Val 
            260                 265                 270


Pro Ala Leu Phe Ser Val Phe Ala Tyr Arg Phe Gly Gly Arg Ser Val 
        275                 280                 285


Pro Cys Tyr Val His Ile Leu Leu Ala Ser Leu Tyr Val Val Ile Pro 
    290                 295                 300


Pro Met Leu Asn Pro Val Ile Tyr Gly Val Arg Thr Lys Pro Ile Leu 
305                 310                 315                 320


Glu Gly Ala Lys Gln Met Phe Ser Asn Leu Ala Lys Gly Ser Lys 
                325                 330                 335


<210>  853
<211>  3409
<212>  DNA
<213>  Homo sapiens

<400>  853
gccttccgca aactcctgac ctgtgggtcc atccgttcaa cggccaaagg ctggcggagg     60

agggatcccc tgcctttctc ggaacggaac ggagcagagt cgtgcgtggt tgagtttaga    120

taaaagccga gtgagcgcgc tctgttcctt aagattagtt taaggtgcct tggattgctc    180

tgaagagctt tgaccacctg atattgctta catctggaac ttcttggctt ctcattcccc    240

agatgtgcgg gtcagagagg attctacagg caggaaacat cttagaaatc agggttgggc    300

aggcaggagc caggagagta gctacaatga cttcaccagt actggtggac atacgagaag    360

aggtgacctg ccctatctgc ctggagctcc taacagaacc cctgagcata gactgtggcc    420

acagcttctg ccaagcctgc atcacaccaa atggcaggga atcagtgatt ggtcaagaag    480

gggaaagaag ctgccctgtg tgccagacca gctaccagcc agggaacctg cggcctaatc    540

ggcatctggc caacatagtg aggcggctca gagaggtagt gttgggccct gggaagcagc    600

tgaaagcagt tctttgtgca gaccatggag aaaaactgca gctcttctgt caggaggatg    660

ggaaggtcat ttgctggctt tgtgagcggt ctcaggagca ccgtggtcac cacacgttcc    720

tcgtggagga ggttgcccag gagtaccagg agaagtttca ggagtctcta aagaagctga    780

agaacgagga gcaggaagct gagaagctaa cagcttttat cagagagaag aagacatcct    840

ggaagaatca gatggagcct gagagatgca ggatccagac agagtttaat cagctgcgaa    900

atatcctaga cagagtggag caacgggagc tgaaaaagct ggaacaggaa gagaagaagg    960

ggctacgaat tatagaagag gctgagaatg atctggtcca ccagacccag tcgctgcgag   1020

agctcatctc ggatctggag cgtcgatgtc aggggtcaac aatggagctg ctgcaggatg   1080

tgagtgatgt cacagaaagg agtgagttct ggaccctgag gaagccagaa gctctcccta   1140

caaagctgag aagtatgttc cgagccccag atctgaaaag gatgctgcga gtgtgtagag   1200

agctgacaga tgtccaaagc tactgggttg acgtgaccct gaatccacac acagctaatt   1260

taaatcttgt cctggctaaa aaccggagac aagtgaggtt tgtgggagct aaagtatctg   1320

gaccttcctg tctggaaaag cattatgact gtagtgtcct gggctcccag cacttctcct   1380

ctggtaagca ttactgggag gtagatgtgg ccaagaagac tgcctggatc ctgggggtat   1440

gcagcaattc actgggacct acattctctt tcaaccattt tgctcaaaat cacagtgctt   1500

actccaggta tcagcctcag agtggatact gggtgattgg gttacagcat aaccatgaat   1560

atagggccta tgaggattct tccccttccc tgcttctctc catgacagtg ccccctcgcc   1620

gtgttggggt tttcttagat tatgaggctg gtactgtctc cttttataat gtcacaaacc   1680

atggcttccc catctacact ttctctaaat attactttcc cactactctt tgtccatatt   1740

ttaatccttg caactgtgta attcctatga ccctgcgtcg tccaagctct tgaatattct   1800

tctgttccca cccacttctg ataagtaccc tgaggcttat cagcatgtga ttctcccttc   1860

tgatcttctg tttttctgtg ttctcaattc ttttgttgtt ttttggtttt tgaatctttt   1920

ttgagatgga atctcgctct gtcgcccagg ctggagtgca ctggcgcaat ctcggctcac   1980

tgcaacctct gcctcctggg ttcaagcgaa cctcctgcct cagcatccca agtagctggg   2040

attacaggca cccaccacca tgcccaacta atttttgtat ttttatagag atagggtttc   2100

accgtgttgg ccaggctgat ctcgaactcc tgaccgcaag tgatccaccc gcctcggtct   2160

cccaaagtgc tgggattaca gatgtgagcc gccgcgccca gacagttctt tcgttttaaa   2220

cagttactca gtactaggat gcacccagtg gtgagagtaa gcatctttga ctgatgacag   2280

gtcttgaggt ggataggggg cgctttcagt attttgccat taagcatagt atttgatgca   2340

ggtttttttt gattgatgca ggggatcaaa tttaggaagt tctgatctgt taatttacta   2400

caagtttttg tataaaatga aaactcgtat tctacctatg tcttttctgt aaattattga   2460

gacaattgtg tatcattttt gttctgttaa tgtggcttag tacattgatt tacttcaatt   2520

tgttaccaca acttgctgaa atacaccatt attatttgtt gtatgcaata ctggatttat   2580

tttgataacg tattgtttag attttgttct catctatgtt aatgaaagaa attggcctgt   2640

atttttacat tcttgtaata tctttgccag gttctataaa atgcaataat aagcaaataa   2700

attactttgt ttttgtataa gtatgtatag gattgagctc taaaaccaaa ccattataat   2760

gataatttgg gtagcttcaa actcaaattg aagagagtct tcactacaat cttcactaca   2820

acctttggcc ttcctctcta catttaagag tagcaataga acaataaaaa aaaatacgtc   2880

tttcaaatta attgcagtaa aaacaaaaga gtagtgggga gagaaaaaca atccaataca   2940

tatttttctc tcagaataga aagaaaacac aaagagaaaa tatgaacaat ataaagcact   3000

taaaggaaga ggatgatttc ttccagcttt tccacactct ctttatgcgc aggaacaaac   3060

agctgttgag tgagctgcta tgactttggt agagaggtgc aatatgtttt ttgaaccagc   3120

tataaaagaa attaagaggt acatgtgagg gtagaaacaa atatcaagga tgagaatggc   3180

actggctgtc ccatatggta tccaggagcc accaatgtct gttgagtact tcatacatgc   3240

ctagtctgaa ttgagatgtg ctcaatgtat aaaatatata ccagatttca aatacctact   3300

tcaaaaaata atgtaaaata tctcactaat aacttttcct ttgtgtattg caatgataat   3360

atgttggctc tattggatta aataaagtat gttattcatt ttacctgtt               3409


<210>  854
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  854

Met Cys Gly Ser Glu Arg Ile Leu Gln Ala Gly Asn Ile Leu Glu Ile 
1               5                   10                  15


Arg Val Gly Gln Ala Gly Ala Arg Arg Val Ala Thr Met Thr Ser Pro 
            20                  25                  30


Val Leu Val Asp Ile Arg Glu Glu Val Thr Cys Pro Ile Cys Leu Glu 
        35                  40                  45


Leu Leu Thr Glu Pro Leu Ser Ile Asp Cys Gly His Ser Phe Cys Gln 
    50                  55                  60


Ala Cys Ile Thr Pro Asn Gly Arg Glu Ser Val Ile Gly Gln Glu Gly 
65                  70                  75                  80


Glu Arg Ser Cys Pro Val Cys Gln Thr Ser Tyr Gln Pro Gly Asn Leu 
                85                  90                  95


Arg Pro Asn Arg His Leu Ala Asn Ile Val Arg Arg Leu Arg Glu Val 
            100                 105                 110


Val Leu Gly Pro Gly Lys Gln Leu Lys Ala Val Leu Cys Ala Asp His 
        115                 120                 125


Gly Glu Lys Leu Gln Leu Phe Cys Gln Glu Asp Gly Lys Val Ile Cys 
    130                 135                 140


Trp Leu Cys Glu Arg Ser Gln Glu His Arg Gly His His Thr Phe Leu 
145                 150                 155                 160


Val Glu Glu Val Ala Gln Glu Tyr Gln Glu Lys Phe Gln Glu Ser Leu 
                165                 170                 175


Lys Lys Leu Lys Asn Glu Glu Gln Glu Ala Glu Lys Leu Thr Ala Phe 
            180                 185                 190


Ile Arg Glu Lys Lys Thr Ser Trp Lys Asn Gln Met Glu Pro Glu Arg 
        195                 200                 205


Cys Arg Ile Gln Thr Glu Phe Asn Gln Leu Arg Asn Ile Leu Asp Arg 
    210                 215                 220


Val Glu Gln Arg Glu Leu Lys Lys Leu Glu Gln Glu Glu Lys Lys Gly 
225                 230                 235                 240


Leu Arg Ile Ile Glu Glu Ala Glu Asn Asp Leu Val His Gln Thr Gln 
                245                 250                 255


Ser Leu Arg Glu Leu Ile Ser Asp Leu Glu Arg Arg Cys Gln Gly Ser 
            260                 265                 270


Thr Met Glu Leu Leu Gln Asp Val Ser Asp Val Thr Glu Arg Ser Glu 
        275                 280                 285


Phe Trp Thr Leu Arg Lys Pro Glu Ala Leu Pro Thr Lys Leu Arg Ser 
    290                 295                 300


Met Phe Arg Ala Pro Asp Leu Lys Arg Met Leu Arg Val Cys Arg Glu 
305                 310                 315                 320


Leu Thr Asp Val Gln Ser Tyr Trp Val Asp Val Thr Leu Asn Pro His 
                325                 330                 335


Thr Ala Asn Leu Asn Leu Val Leu Ala Lys Asn Arg Arg Gln Val Arg 
            340                 345                 350


Phe Val Gly Ala Lys Val Ser Gly Pro Ser Cys Leu Glu Lys His Tyr 
        355                 360                 365


Asp Cys Ser Val Leu Gly Ser Gln His Phe Ser Ser Gly Lys His Tyr 
    370                 375                 380


Trp Glu Val Asp Val Ala Lys Lys Thr Ala Trp Ile Leu Gly Val Cys 
385                 390                 395                 400


Ser Asn Ser Leu Gly Pro Thr Phe Ser Phe Asn His Phe Ala Gln Asn 
                405                 410                 415


His Ser Ala Tyr Ser Arg Tyr Gln Pro Gln Ser Gly Tyr Trp Val Ile 
            420                 425                 430


Gly Leu Gln His Asn His Glu Tyr Arg Ala Tyr Glu Asp Ser Ser Pro 
        435                 440                 445


Ser Leu Leu Leu Ser Met Thr Val Pro Pro Arg Arg Val Gly Val Phe 
    450                 455                 460


Leu Asp Tyr Glu Ala Gly Thr Val Ser Phe Tyr Asn Val Thr Asn His 
465                 470                 475                 480


Gly Phe Pro Ile Tyr Thr Phe Ser Lys Tyr Tyr Phe Pro Thr Thr Leu 
                485                 490                 495


Cys Pro Tyr Phe Asn Pro Cys Asn Cys Val Ile Pro Met Thr Leu Arg 
            500                 505                 510


Arg Pro Ser Ser 
        515


<210>  855
<211>  3215
<212>  DNA
<213>  Homo sapiens

<400>  855
ttcggcctgg gtggaggacg cggctgcttc aagtccttgg ctctgatcca ggccacagat     60

tccaggattc tacaggcagg aaacatctta gaaatcaggg ttgggcaggc aggagccagg    120

agagtagcta caatgacttc accagtactg gtggacatac gagaagaggt gacctgccct    180

atctgcctgg agctcctaac agaacccctg agcatagact gtggccacag cttctgccaa    240

gcctgcatca caccaaatgg cagggaatca gtgattggtc aagaagggga aagaagctgc    300

cctgtgtgcc agaccagcta ccagccaggg aacctgcggc ctaatcggca tctggccaac    360

atagtgaggc ggctcagaga ggtagtgttg ggccctggga agcagctgaa agcagttctt    420

tgtgcagacc atggagaaaa actgcagctc ttctgtcagg aggatgggaa ggtcatttgc    480

tggctttgtg agcggtctca ggagcaccgt ggtcaccaca cgttcctcgt ggaggaggtt    540

gcccaggagt accaggagaa gtttcaggag tctctaaaga agctgaagaa cgaggagcag    600

gaagctgaga agctaacagc ttttatcaga gagaagaaga catcctggaa gaatcagatg    660

gagcctgaga gatgcaggat ccagacagag tttaatcagc tgcgaaatat cctagacaga    720

gtggagcaac gggagctgaa aaagctggaa caggaagaga agaaggggct acgaattata    780

gaagaggctg agaatgatct ggtccaccag acccagtcgc tgcgagagct catctcggat    840

ctggagcgtc gatgtcaggg gtcaacaatg gagctgctgc aggatgtgag tgatgtcaca    900

gaaaggagtg agttctggac cctgaggaag ccagaagctc tccctacaaa gctgagaagt    960

atgttccgag ccccagatct gaaaaggatg ctgcgagtgt gtagagagct gacagatgtc   1020

caaagctact gggttgacgt gaccctgaat ccacacacag ctaatttaaa tcttgtcctg   1080

gctaaaaacc ggagacaagt gaggtttgtg ggagctaaag tatctggacc ttcctgtctg   1140

gaaaagcatt atgactgtag tgtcctgggc tcccagcact tctcctctgg taagcattac   1200

tgggaggtag atgtggccaa gaagactgcc tggatcctgg gggtatgcag caattcactg   1260

ggacctacat tctctttcaa ccattttgct caaaatcaca gtgcttactc caggtatcag   1320

cctcagagtg gatactgggt gattgggtta cagcataacc atgaatatag ggcctatgag   1380

gattcttccc cttccctgct tctctccatg acagtgcccc ctcgccgtgt tggggttttc   1440

ttagattatg aggctggtac tgtctccttt tataatgtca caaaccatgg cttccccatc   1500

tacactttct ctaaatatta ctttcccact actctttgtc catattttaa tccttgcaac   1560

tgtgtaattc ctatgaccct gcgtcgtcca agctcttgaa tattcttctg ttcccaccca   1620

cttctgataa gtaccctgag gcttatcagc atgtgattct cccttctgat cttctgtttt   1680

tctgtgttct caattctttt gttgtttttt ggtttttgaa tcttttttga gatggaatct   1740

cgctctgtcg cccaggctgg agtgcactgg cgcaatctcg gctcactgca acctctgcct   1800

cctgggttca agcgaacctc ctgcctcagc atcccaagta gctgggatta caggcaccca   1860

ccaccatgcc caactaattt ttgtattttt atagagatag ggtttcaccg tgttggccag   1920

gctgatctcg aactcctgac cgcaagtgat ccacccgcct cggtctccca aagtgctggg   1980

attacagatg tgagccgccg cgcccagaca gttctttcgt tttaaacagt tactcagtac   2040

taggatgcac ccagtggtga gagtaagcat ctttgactga tgacaggtct tgaggtggat   2100

agggggcgct ttcagtattt tgccattaag catagtattt gatgcaggtt ttttttgatt   2160

gatgcagggg atcaaattta ggaagttctg atctgttaat ttactacaag tttttgtata   2220

aaatgaaaac tcgtattcta cctatgtctt ttctgtaaat tattgagaca attgtgtatc   2280

atttttgttc tgttaatgtg gcttagtaca ttgatttact tcaatttgtt accacaactt   2340

gctgaaatac accattatta tttgttgtat gcaatactgg atttattttg ataacgtatt   2400

gtttagattt tgttctcatc tatgttaatg aaagaaattg gcctgtattt ttacattctt   2460

gtaatatctt tgccaggttc tataaaatgc aataataagc aaataaatta ctttgttttt   2520

gtataagtat gtataggatt gagctctaaa accaaaccat tataatgata atttgggtag   2580

cttcaaactc aaattgaaga gagtcttcac tacaatcttc actacaacct ttggccttcc   2640

tctctacatt taagagtagc aatagaacaa taaaaaaaaa tacgtctttc aaattaattg   2700

cagtaaaaac aaaagagtag tggggagaga aaaacaatcc aatacatatt tttctctcag   2760

aatagaaaga aaacacaaag agaaaatatg aacaatataa agcacttaaa ggaagaggat   2820

gatttcttcc agcttttcca cactctcttt atgcgcagga acaaacagct gttgagtgag   2880

ctgctatgac tttggtagag aggtgcaata tgttttttga accagctata aaagaaatta   2940

agaggtacat gtgagggtag aaacaaatat caaggatgag aatggcactg gctgtcccat   3000

atggtatcca ggagccacca atgtctgttg agtacttcat acatgcctag tctgaattga   3060

gatgtgctca atgtataaaa tatataccag atttcaaata cctacttcaa aaaataatgt   3120

aaaatatctc actaataact tttcctttgt gtattgcaat gataatatgt tggctctatt   3180

ggattaaata aagtatgtta ttcattttac ctgtt                              3215


<210>  856
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  856

Met Thr Ser Pro Val Leu Val Asp Ile Arg Glu Glu Val Thr Cys Pro 
1               5                   10                  15


Ile Cys Leu Glu Leu Leu Thr Glu Pro Leu Ser Ile Asp Cys Gly His 
            20                  25                  30


Ser Phe Cys Gln Ala Cys Ile Thr Pro Asn Gly Arg Glu Ser Val Ile 
        35                  40                  45


Gly Gln Glu Gly Glu Arg Ser Cys Pro Val Cys Gln Thr Ser Tyr Gln 
    50                  55                  60


Pro Gly Asn Leu Arg Pro Asn Arg His Leu Ala Asn Ile Val Arg Arg 
65                  70                  75                  80


Leu Arg Glu Val Val Leu Gly Pro Gly Lys Gln Leu Lys Ala Val Leu 
                85                  90                  95


Cys Ala Asp His Gly Glu Lys Leu Gln Leu Phe Cys Gln Glu Asp Gly 
            100                 105                 110


Lys Val Ile Cys Trp Leu Cys Glu Arg Ser Gln Glu His Arg Gly His 
        115                 120                 125


His Thr Phe Leu Val Glu Glu Val Ala Gln Glu Tyr Gln Glu Lys Phe 
    130                 135                 140


Gln Glu Ser Leu Lys Lys Leu Lys Asn Glu Glu Gln Glu Ala Glu Lys 
145                 150                 155                 160


Leu Thr Ala Phe Ile Arg Glu Lys Lys Thr Ser Trp Lys Asn Gln Met 
                165                 170                 175


Glu Pro Glu Arg Cys Arg Ile Gln Thr Glu Phe Asn Gln Leu Arg Asn 
            180                 185                 190


Ile Leu Asp Arg Val Glu Gln Arg Glu Leu Lys Lys Leu Glu Gln Glu 
        195                 200                 205


Glu Lys Lys Gly Leu Arg Ile Ile Glu Glu Ala Glu Asn Asp Leu Val 
    210                 215                 220


His Gln Thr Gln Ser Leu Arg Glu Leu Ile Ser Asp Leu Glu Arg Arg 
225                 230                 235                 240


Cys Gln Gly Ser Thr Met Glu Leu Leu Gln Asp Val Ser Asp Val Thr 
                245                 250                 255


Glu Arg Ser Glu Phe Trp Thr Leu Arg Lys Pro Glu Ala Leu Pro Thr 
            260                 265                 270


Lys Leu Arg Ser Met Phe Arg Ala Pro Asp Leu Lys Arg Met Leu Arg 
        275                 280                 285


Val Cys Arg Glu Leu Thr Asp Val Gln Ser Tyr Trp Val Asp Val Thr 
    290                 295                 300


Leu Asn Pro His Thr Ala Asn Leu Asn Leu Val Leu Ala Lys Asn Arg 
305                 310                 315                 320


Arg Gln Val Arg Phe Val Gly Ala Lys Val Ser Gly Pro Ser Cys Leu 
                325                 330                 335


Glu Lys His Tyr Asp Cys Ser Val Leu Gly Ser Gln His Phe Ser Ser 
            340                 345                 350


Gly Lys His Tyr Trp Glu Val Asp Val Ala Lys Lys Thr Ala Trp Ile 
        355                 360                 365


Leu Gly Val Cys Ser Asn Ser Leu Gly Pro Thr Phe Ser Phe Asn His 
    370                 375                 380


Phe Ala Gln Asn His Ser Ala Tyr Ser Arg Tyr Gln Pro Gln Ser Gly 
385                 390                 395                 400


Tyr Trp Val Ile Gly Leu Gln His Asn His Glu Tyr Arg Ala Tyr Glu 
                405                 410                 415


Asp Ser Ser Pro Ser Leu Leu Leu Ser Met Thr Val Pro Pro Arg Arg 
            420                 425                 430


Val Gly Val Phe Leu Asp Tyr Glu Ala Gly Thr Val Ser Phe Tyr Asn 
        435                 440                 445


Val Thr Asn His Gly Phe Pro Ile Tyr Thr Phe Ser Lys Tyr Tyr Phe 
    450                 455                 460


Pro Thr Thr Leu Cys Pro Tyr Phe Asn Pro Cys Asn Cys Val Ile Pro 
465                 470                 475                 480


Met Thr Leu Arg Arg Pro Ser Ser 
                485


<210>  857
<211>  3490
<212>  DNA
<213>  Homo sapiens

<400>  857
gccttccgca aactcctgac ctgtgggtcc atccgttcaa cggccaaagg ctggcggagg     60

agggatcccc tgcctttctc ggaacggaac ggagcagagt cgtgcgtggt tgagtttaga    120

taaaagccga gtgagcgcgc tctgttcctt aagattagtt taaggtgcct tggattgctc    180

tgaagagctt tgaccacctg atattgctta catctggaac ttcttggctt ctcattcccc    240

agatgtgcgg gtcagagagg attctacagg caggaaacat cttagaaatc agggttgggc    300

aggcaggagc caggagagta gctacaatga cttcaccagt actggtggac atacgagaag    360

aggtgacctg ccctatctgc ctggagctcc taacagaacc cctgagcata gactgtggcc    420

acagcttctg ccaagcctgc atcacaccaa atggcaggga atcagtgatt ggtcaagaag    480

gggaaagaag ctgccctgtg tgccagacca gctaccagcc agggaacctg cggcctaatc    540

ggcatctggc caacatagtg aggcggctca gagaggtagt gttgggccct gggaagcagc    600

tgaaagcagt tctttgtgca gaccatggag aaaaactgca gctcttctgt caggaggatg    660

ggaaggtcat ttgctggctt tgtgagcggt ctcaggagca ccgtggtcac cacacgttcc    720

tcgtggagga ggttgcccag gagtaccagg agaagtttca ggagtctcta aagaagctga    780

agaacgagga gcaggaagct gagaagctaa cagcttttat cagagagaag aagacatcct    840

ggaagaatca gatggagcct gagagatgca ggatccagac agagtttaat cagctgcgaa    900

atatcctaga cagagtggag caacgggagc tgaaaaagct ggaacaggaa gagaagaagg    960

ggctacgaat tatagaagag gctgagaatg atctggtcca ccagacccag tcgctgcgag   1020

agctcatctc ggatctggag cgtcgatgtc aggggtcaac aatggagctg ctgcaggatg   1080

tgagtgatgt cacagaaagg agtgagttct ggaccctgag gaagccagaa gctctcccta   1140

caaagctgag aagtatgttc cgagccccag atctgaaaag gatgctgcga gtgtgtagag   1200

agctgacaga tgtccaaagc tactgggcca tccaggggtc tttaaccaga agagagagga   1260

gagcctcagg agttaggacc agaagaagcc agggaagcag tgcaatggct tcaaaaatct   1320

tgcttaacgt acaagaggag gtgacctgtc ccatctgcct ggagctgttg acagaaccct   1380

tgagtctaga ctgtggccac agcctctgcc gagcctgcat cactgtgagc aacaaggagg   1440

cagtgaccag catgggagga aaaagcagct gtcctgtgtg tggtatcagt tactcatttg   1500

aacatctaca ggctaatcag catctggcca acatagtgga gagactcaag gaggtcaagt   1560

tgagcccaga caatgggaag aagagagatc tctgtgatca tcatggagag aaactcctac   1620

tcttctgtaa ggaggatagg aaagtcattt gctggctttg tgagcggtct caggagcacc   1680

gtggtcacca cacagtcctc acggaggaag tattcaagga atgtcaggag aaactccagg   1740

cagtcctcaa gaggctgaag aaggaagagg aggaagctga gaagctggaa gctgacatca   1800

gagaagagaa aacttcctgg aagtatcagg tacaaactga gagacaaagg atacaaacag   1860

aatttgatca gcttagaagc atcctaaata atgaggagca gagagagctg caaagattgg   1920

aagaagaaga aaagaagacg ctggataagt ttgcagaggc tgaggatgag ctagttcagc   1980

agaagcagtt ggtgagagag ctcatctcag atgtggagtg tcggagtcag tggtcaacaa   2040

tggagctgct gcaggacatg agtggaatca tgaaatggag tgagatctgg aggctgaaaa   2100

agccaaaaat ggtttccaag aaactgaaga ctgtattcca tgctccagat ctgagtagga   2160

tgctgcaaat gtttagagaa ctgacagctg tccggtgcta ctgggtggat gtcacactga   2220

attcagtcaa cctaaatttg aatcttgtcc tttcagaaga tcagagacaa gtgatatctg   2280

tgccaatttg gccttttcag tgttataatt atggtgtctt gggatcccaa tatttctcct   2340

ctgggaaaca ttactgggaa gtggacgtgt ccaagaaaac tgcctggatc ctgggggtat   2400

actgtagaac atattcccgc catatgaagt atgttgttag aagatgtgca aatcgtcaaa   2460

atctttacac caaatacaga cctctatttg gctactgggt tatagggtta cagaataaat   2520

gtaagtatgg tgtctttgaa gagtctttgt cctctgatcc cgaggttttg actctctcca   2580

tggctgtgcc tccctgccgt gttggggttt tcctcgacta tgaagcaggc attgtctcat   2640

ttttcaatgt cacaagccat ggctccctca tttacaagtt ctctaaatgt tgcttttctc   2700

agcctgttta tccatatttc aatccttgga actgtccagc tcccatgact ctatgcccac   2760

caagctcttg aattttctca tttcttcacc tacaaccctt tgtctcgact tatctcctgc   2820

aactgactca tctgcaacat tcacaccatt gcttccttgt ggtttccctt ctttagaact   2880

tttactcatc cttgagatgt atggtgtatt tggcttgagt tatgagagat gcttatttat   2940

tcatttactc tttttcatat tttcagagaa agttacctaa tccctcctaa agacacagca   3000

gtatgggtat aacatccttg ccttcccatt tatccatgtt tcactttatc actgatgtga   3060

agaggcccaa agcctgttag ccaccatcca tgctacctag gtagtccata ggaaccaccc   3120

ccatgaccac caccaacatc aactaaaggt tcttggaggg tatgtcagtg tgttgctcag   3180

gataccccag gtacatcaag gaatcaagga gaggaaaata tgagcaatat gtgtattcag   3240

agtgaagatt ttatgtccag agtatttgag ctcaaacctt gcctgttgtt ttctaatcat   3300

gatgaatact ttctcagttt ctttttcctg aaatataaat tgggatttaa gactgtacct   3360

aactattaag atcactgtgt aaaactaagt gtctctaaat gtaatgcatc gatttagtgt   3420

ctggaacata ataaatattt gctctcatga ttgctaaaaa aaaaaaaaaa aaaaaaaaaa   3480

aaaaaaaaaa                                                          3490


<210>  858
<211>  842
<212>  PRT
<213>  Homo sapiens

<400>  858

Met Cys Gly Ser Glu Arg Ile Leu Gln Ala Gly Asn Ile Leu Glu Ile 
1               5                   10                  15


Arg Val Gly Gln Ala Gly Ala Arg Arg Val Ala Thr Met Thr Ser Pro 
            20                  25                  30


Val Leu Val Asp Ile Arg Glu Glu Val Thr Cys Pro Ile Cys Leu Glu 
        35                  40                  45


Leu Leu Thr Glu Pro Leu Ser Ile Asp Cys Gly His Ser Phe Cys Gln 
    50                  55                  60


Ala Cys Ile Thr Pro Asn Gly Arg Glu Ser Val Ile Gly Gln Glu Gly 
65                  70                  75                  80


Glu Arg Ser Cys Pro Val Cys Gln Thr Ser Tyr Gln Pro Gly Asn Leu 
                85                  90                  95


Arg Pro Asn Arg His Leu Ala Asn Ile Val Arg Arg Leu Arg Glu Val 
            100                 105                 110


Val Leu Gly Pro Gly Lys Gln Leu Lys Ala Val Leu Cys Ala Asp His 
        115                 120                 125


Gly Glu Lys Leu Gln Leu Phe Cys Gln Glu Asp Gly Lys Val Ile Cys 
    130                 135                 140


Trp Leu Cys Glu Arg Ser Gln Glu His Arg Gly His His Thr Phe Leu 
145                 150                 155                 160


Val Glu Glu Val Ala Gln Glu Tyr Gln Glu Lys Phe Gln Glu Ser Leu 
                165                 170                 175


Lys Lys Leu Lys Asn Glu Glu Gln Glu Ala Glu Lys Leu Thr Ala Phe 
            180                 185                 190


Ile Arg Glu Lys Lys Thr Ser Trp Lys Asn Gln Met Glu Pro Glu Arg 
        195                 200                 205


Cys Arg Ile Gln Thr Glu Phe Asn Gln Leu Arg Asn Ile Leu Asp Arg 
    210                 215                 220


Val Glu Gln Arg Glu Leu Lys Lys Leu Glu Gln Glu Glu Lys Lys Gly 
225                 230                 235                 240


Leu Arg Ile Ile Glu Glu Ala Glu Asn Asp Leu Val His Gln Thr Gln 
                245                 250                 255


Ser Leu Arg Glu Leu Ile Ser Asp Leu Glu Arg Arg Cys Gln Gly Ser 
            260                 265                 270


Thr Met Glu Leu Leu Gln Asp Val Ser Asp Val Thr Glu Arg Ser Glu 
        275                 280                 285


Phe Trp Thr Leu Arg Lys Pro Glu Ala Leu Pro Thr Lys Leu Arg Ser 
    290                 295                 300


Met Phe Arg Ala Pro Asp Leu Lys Arg Met Leu Arg Val Cys Arg Glu 
305                 310                 315                 320


Leu Thr Asp Val Gln Ser Tyr Trp Ala Ile Gln Gly Ser Leu Thr Arg 
                325                 330                 335


Arg Glu Arg Arg Ala Ser Gly Val Arg Thr Arg Arg Ser Gln Gly Ser 
            340                 345                 350


Ser Ala Met Ala Ser Lys Ile Leu Leu Asn Val Gln Glu Glu Val Thr 
        355                 360                 365


Cys Pro Ile Cys Leu Glu Leu Leu Thr Glu Pro Leu Ser Leu Asp Cys 
    370                 375                 380


Gly His Ser Leu Cys Arg Ala Cys Ile Thr Val Ser Asn Lys Glu Ala 
385                 390                 395                 400


Val Thr Ser Met Gly Gly Lys Ser Ser Cys Pro Val Cys Gly Ile Ser 
                405                 410                 415


Tyr Ser Phe Glu His Leu Gln Ala Asn Gln His Leu Ala Asn Ile Val 
            420                 425                 430


Glu Arg Leu Lys Glu Val Lys Leu Ser Pro Asp Asn Gly Lys Lys Arg 
        435                 440                 445


Asp Leu Cys Asp His His Gly Glu Lys Leu Leu Leu Phe Cys Lys Glu 
    450                 455                 460


Asp Arg Lys Val Ile Cys Trp Leu Cys Glu Arg Ser Gln Glu His Arg 
465                 470                 475                 480


Gly His His Thr Val Leu Thr Glu Glu Val Phe Lys Glu Cys Gln Glu 
                485                 490                 495


Lys Leu Gln Ala Val Leu Lys Arg Leu Lys Lys Glu Glu Glu Glu Ala 
            500                 505                 510


Glu Lys Leu Glu Ala Asp Ile Arg Glu Glu Lys Thr Ser Trp Lys Tyr 
        515                 520                 525


Gln Val Gln Thr Glu Arg Gln Arg Ile Gln Thr Glu Phe Asp Gln Leu 
    530                 535                 540


Arg Ser Ile Leu Asn Asn Glu Glu Gln Arg Glu Leu Gln Arg Leu Glu 
545                 550                 555                 560


Glu Glu Glu Lys Lys Thr Leu Asp Lys Phe Ala Glu Ala Glu Asp Glu 
                565                 570                 575


Leu Val Gln Gln Lys Gln Leu Val Arg Glu Leu Ile Ser Asp Val Glu 
            580                 585                 590


Cys Arg Ser Gln Trp Ser Thr Met Glu Leu Leu Gln Asp Met Ser Gly 
        595                 600                 605


Ile Met Lys Trp Ser Glu Ile Trp Arg Leu Lys Lys Pro Lys Met Val 
    610                 615                 620


Ser Lys Lys Leu Lys Thr Val Phe His Ala Pro Asp Leu Ser Arg Met 
625                 630                 635                 640


Leu Gln Met Phe Arg Glu Leu Thr Ala Val Arg Cys Tyr Trp Val Asp 
                645                 650                 655


Val Thr Leu Asn Ser Val Asn Leu Asn Leu Asn Leu Val Leu Ser Glu 
            660                 665                 670


Asp Gln Arg Gln Val Ile Ser Val Pro Ile Trp Pro Phe Gln Cys Tyr 
        675                 680                 685


Asn Tyr Gly Val Leu Gly Ser Gln Tyr Phe Ser Ser Gly Lys His Tyr 
    690                 695                 700


Trp Glu Val Asp Val Ser Lys Lys Thr Ala Trp Ile Leu Gly Val Tyr 
705                 710                 715                 720


Cys Arg Thr Tyr Ser Arg His Met Lys Tyr Val Val Arg Arg Cys Ala 
                725                 730                 735


Asn Arg Gln Asn Leu Tyr Thr Lys Tyr Arg Pro Leu Phe Gly Tyr Trp 
            740                 745                 750


Val Ile Gly Leu Gln Asn Lys Cys Lys Tyr Gly Val Phe Glu Glu Ser 
        755                 760                 765


Leu Ser Ser Asp Pro Glu Val Leu Thr Leu Ser Met Ala Val Pro Pro 
    770                 775                 780


Cys Arg Val Gly Val Phe Leu Asp Tyr Glu Ala Gly Ile Val Ser Phe 
785                 790                 795                 800


Phe Asn Val Thr Ser His Gly Ser Leu Ile Tyr Lys Phe Ser Lys Cys 
                805                 810                 815


Cys Phe Ser Gln Pro Val Tyr Pro Tyr Phe Asn Pro Trp Asn Cys Pro 
            820                 825                 830


Ala Pro Met Thr Leu Cys Pro Pro Ser Ser 
        835                 840


<210>  859
<211>  2326
<212>  DNA
<213>  Homo sapiens

<400>  859
cccgcctcag cctcccaaag tgctgggatt acaggtgtga gccactgcgc ccgtcctgac     60

tcatgcaact tctgcttcag ccatccaggg gtctttaacc agaagagaga ggagagcctc    120

aggagttagg accagaagaa gccagggaag cagtgcaatg gcttcaaaaa tcttgcttaa    180

cgtacaagag gaggtgacct gtcccatctg cctggagctg ttgacagaac ccttgagtct    240

agactgtggc cacagcctct gccgagcctg catcactgtg agcaacaagg aggcagtgac    300

cagcatggga ggaaaaagca gctgtcctgt gtgtggtatc agttactcat ttgaacatct    360

acaggctaat cagcatctgg ccaacatagt ggagagactc aaggaggtca agttgagccc    420

agacaatggg aagaagagag atctctgtga tcatcatgga gagaaactcc tactcttctg    480

taaggaggat aggaaagtca tttgctggct ttgtgagcgg tctcaggagc accgtggtca    540

ccacacagtc ctcacggagg aagtattcaa ggaatgtcag gagaaactcc aggcagtcct    600

caagaggctg aagaaggaag aggaggaagc tgagaagctg gaagctgaca tcagagaaga    660

gaaaacttcc tggaagtatc aggtacaaac tgagagacaa aggatacaaa cagaatttga    720

tcagcttaga agcatcctaa ataatgagga gcagagagag ctgcaaagat tggaagaaga    780

agaaaagaag acgctggata agtttgcaga ggctgaggat gagctagttc agcagaagca    840

gttggtgaga gagctcatct cagatgtgga gtgtcggagt cagtggtcaa caatggagct    900

gctgcaggac atgagtggaa tcatgaaatg gagtgagatc tggaggctga aaaagccaaa    960

aatggtttcc aagaaactga agactgtatt ccatgctcca gatctgagta ggatgctgca   1020

aatgtttaga gaactgacag ctgtccggtg ctactgggtg gatgtcacac tgaattcagt   1080

caacctaaat ttgaatcttg tcctttcaga agatcagaga caagtgatat ctgtgccaat   1140

ttggcctttt cagtgttata attatggtgt cttgggatcc caatatttct cctctgggaa   1200

acattactgg gaagtggacg tgtccaagaa aactgcctgg atcctggggg tatactgtag   1260

aacatattcc cgccatatga agtatgttgt tagaagatgt gcaaatcgtc aaaatcttta   1320

caccaaatac agacctctat ttggctactg ggttataggg ttacagaata aatgtaagta   1380

tggtgtcttt gaagagtctt tgtcctctga tcccgaggtt ttgactctct ccatggctgt   1440

gcctccctgc cgtgttgggg ttttcctcga ctatgaagca ggcattgtct catttttcaa   1500

tgtcacaagc catggctccc tcatttacaa gttctctaaa tgttgctttt ctcagcctgt   1560

ttatccatat ttcaatcctt ggaactgtcc agctcccatg actctatgcc caccaagctc   1620

ttgaattttc tcatttcttc acctacaacc ctttgtcttg acttatctcc tgcaactgac   1680

tcatctgcaa cattcacacc attgcttcct tgtggtttcc cttctttaga acttttactc   1740

atccttgaga tgtatggtgt atttggcttg agttatgaga gatgcttatt tattcattta   1800

ctctttttca tattttcaga gaaagttacc taatccctcc taaagacaca gcagtatggg   1860

tataacatcc ttgccttccc atttatccat gtttcacttt atcactgata tgaagaggcc   1920

caaagcctgt tagccaccat ccatgctacc taggtagtcc ataggaacca cccccatgac   1980

caccaccaac atcaactaaa ggttcttgga gggtatgtca gtgtgttgct caggataccc   2040

caggtacatc aaggaatcaa ggagaggaaa atatgagcaa tatgtgtatt cagagtgaag   2100

attttatgtc cagagtattt gagctcaaac cttgcctgtt gttttctaat catgatgaat   2160

actttctcag tttctttttc ctgaaatata aattgggatt taagactgta cctaactatt   2220

aagatcactg tgtaaaacta agtgtctcta aatgtaatgc atcgatttag tgtctggaac   2280

ataataaata tttgctctca tgattgctaa aaaaaaaaaa aaaaaa                  2326


<210>  860
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  860

Met Ala Ser Lys Ile Leu Leu Asn Val Gln Glu Glu Val Thr Cys Pro 
1               5                   10                  15


Ile Cys Leu Glu Leu Leu Thr Glu Pro Leu Ser Leu Asp Cys Gly His 
            20                  25                  30


Ser Leu Cys Arg Ala Cys Ile Thr Val Ser Asn Lys Glu Ala Val Thr 
        35                  40                  45


Ser Met Gly Gly Lys Ser Ser Cys Pro Val Cys Gly Ile Ser Tyr Ser 
    50                  55                  60


Phe Glu His Leu Gln Ala Asn Gln His Leu Ala Asn Ile Val Glu Arg 
65                  70                  75                  80


Leu Lys Glu Val Lys Leu Ser Pro Asp Asn Gly Lys Lys Arg Asp Leu 
                85                  90                  95


Cys Asp His His Gly Glu Lys Leu Leu Leu Phe Cys Lys Glu Asp Arg 
            100                 105                 110


Lys Val Ile Cys Trp Leu Cys Glu Arg Ser Gln Glu His Arg Gly His 
        115                 120                 125


His Thr Val Leu Thr Glu Glu Val Phe Lys Glu Cys Gln Glu Lys Leu 
    130                 135                 140


Gln Ala Val Leu Lys Arg Leu Lys Lys Glu Glu Glu Glu Ala Glu Lys 
145                 150                 155                 160


Leu Glu Ala Asp Ile Arg Glu Glu Lys Thr Ser Trp Lys Tyr Gln Val 
                165                 170                 175


Gln Thr Glu Arg Gln Arg Ile Gln Thr Glu Phe Asp Gln Leu Arg Ser 
            180                 185                 190


Ile Leu Asn Asn Glu Glu Gln Arg Glu Leu Gln Arg Leu Glu Glu Glu 
        195                 200                 205


Glu Lys Lys Thr Leu Asp Lys Phe Ala Glu Ala Glu Asp Glu Leu Val 
    210                 215                 220


Gln Gln Lys Gln Leu Val Arg Glu Leu Ile Ser Asp Val Glu Cys Arg 
225                 230                 235                 240


Ser Gln Trp Ser Thr Met Glu Leu Leu Gln Asp Met Ser Gly Ile Met 
                245                 250                 255


Lys Trp Ser Glu Ile Trp Arg Leu Lys Lys Pro Lys Met Val Ser Lys 
            260                 265                 270


Lys Leu Lys Thr Val Phe His Ala Pro Asp Leu Ser Arg Met Leu Gln 
        275                 280                 285


Met Phe Arg Glu Leu Thr Ala Val Arg Cys Tyr Trp Val Asp Val Thr 
    290                 295                 300


Leu Asn Ser Val Asn Leu Asn Leu Asn Leu Val Leu Ser Glu Asp Gln 
305                 310                 315                 320


Arg Gln Val Ile Ser Val Pro Ile Trp Pro Phe Gln Cys Tyr Asn Tyr 
                325                 330                 335


Gly Val Leu Gly Ser Gln Tyr Phe Ser Ser Gly Lys His Tyr Trp Glu 
            340                 345                 350


Val Asp Val Ser Lys Lys Thr Ala Trp Ile Leu Gly Val Tyr Cys Arg 
        355                 360                 365


Thr Tyr Ser Arg His Met Lys Tyr Val Val Arg Arg Cys Ala Asn Arg 
    370                 375                 380


Gln Asn Leu Tyr Thr Lys Tyr Arg Pro Leu Phe Gly Tyr Trp Val Ile 
385                 390                 395                 400


Gly Leu Gln Asn Lys Cys Lys Tyr Gly Val Phe Glu Glu Ser Leu Ser 
                405                 410                 415


Ser Asp Pro Glu Val Leu Thr Leu Ser Met Ala Val Pro Pro Cys Arg 
            420                 425                 430


Val Gly Val Phe Leu Asp Tyr Glu Ala Gly Ile Val Ser Phe Phe Asn 
        435                 440                 445


Val Thr Ser His Gly Ser Leu Ile Tyr Lys Phe Ser Lys Cys Cys Phe 
    450                 455                 460


Ser Gln Pro Val Tyr Pro Tyr Phe Asn Pro Trp Asn Cys Pro Ala Pro 
465                 470                 475                 480


Met Thr Leu Cys Pro Pro Ser Ser 
                485


<210>  861
<211>  2302
<212>  DNA
<213>  Homo sapiens

<400>  861
accctggctt ttcttcacct cttcaaccag gagccgagat ttctgttgct ctgaagccat     60

ccaggggtct ttaaccagaa gagagaggag agcctcagga gttaggacca gaagaagcca    120

gggaagcagt gcaatggctt caaaaatctt gcttaacgta caagaggagg tgacctgtcc    180

catctgcctg gagctgttga cagaaccctt gagtctagac tgtggccaca gcctctgccg    240

agcctgcatc actgtgagca acaaggaggc agtgaccagc atgggaggaa aaagcagctg    300

tcctgtgtgt ggtatcagtt actcatttga acatctacag gctaatcagc atctggccaa    360

catagtggag agactcaagg aggtcaagtt gagcccagac aatgggaaga agagagatct    420

ctgtgatcat catggagaga aactcctact cttctgtaag gaggatagga aagtcatttg    480

ctggctttgt gagcggtctc aggagcaccg tggtcaccac acagtcctca cggaggaagt    540

attcaaggaa tgtcaggaga aactccaggc agtcctcaag aggctgaaga aggaagagga    600

ggaagctgag aagctggaag ctgacatcag agaagagaaa acttcctgga agtatcaggt    660

acaaactgag agacaaagga tacaaacaga atttgatcag cttagaagca tcctaaataa    720

tgaggagcag agagagctgc aaagattgga agaagaagaa aagaagacgc tggataagtt    780

tgcagaggct gaggatgagc tagttcagca gaagcagttg gtgagagagc tcatctcaga    840

tgtggagtgt cggagtcagt ggtcaacaat ggagctgctg caggacatga gtggaatcat    900

gaaatggagt gagatctgga ggctgaaaaa gccaaaaatg gtttccaaga aactgaagac    960

tgtattccat gctccagatc tgagtaggat gctgcaaatg tttagagaac tgacagctgt   1020

ccggtgctac tgggtggatg tcacactgaa ttcagtcaac ctaaatttga atcttgtcct   1080

ttcagaagat cagagacaag tgatatctgt gccaatttgg ccttttcagt gttataatta   1140

tggtgtcttg ggatcccaat atttctcctc tgggaaacat tactgggaag tggacgtgtc   1200

caagaaaact gcctggatcc tgggggtata ctgtagaaca tattcccgcc atatgaagta   1260

tgttgttaga agatgtgcaa atcgtcaaaa tctttacacc aaatacagac ctctatttgg   1320

ctactgggtt atagggttac agaataaatg taagtatggt gtctttgaag agtctttgtc   1380

ctctgatccc gaggttttga ctctctccat ggctgtgcct ccctgccgtg ttggggtttt   1440

cctcgactat gaagcaggca ttgtctcatt tttcaatgtc acaagccatg gctccctcat   1500

ttacaagttc tctaaatgtt gcttttctca gcctgtttat ccatatttca atccttggaa   1560

ctgtccagct cccatgactc tatgcccacc aagctcttga attttctcat ttcttcacct   1620

acaacccttt gtcttgactt atctcctgca actgactcat ctgcaacatt cacaccattg   1680

cttccttgtg gtttcccttc tttagaactt ttactcatcc ttgagatgta tggtgtattt   1740

ggcttgagtt atgagagatg cttatttatt catttactct ttttcatatt ttcagagaaa   1800

gttacctaat ccctcctaaa gacacagcag tatgggtata acatccttgc cttcccattt   1860

atccatgttt cactttatca ctgatatgaa gaggcccaaa gcctgttagc caccatccat   1920

gctacctagg tagtccatag gaaccacccc catgaccacc accaacatca actaaaggtt   1980

cttggagggt atgtcagtgt gttgctcagg ataccccagg tacatcaagg aatcaaggag   2040

aggaaaatat gagcaatatg tgtattcaga gtgaagattt tatgtccaga gtatttgagc   2100

tcaaaccttg cctgttgttt tctaatcatg atgaatactt tctcagtttc tttttcctga   2160

aatataaatt gggatttaag actgtaccta actattaaga tcactgtgta aaactaagtg   2220

tctctaaatg taatgcatcg atttagtgtc tggaacataa taaatatttg ctctcatgat   2280

tgctaaaaaa aaaaaaaaaa aa                                            2302


<210>  862
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  862

Met Ala Ser Lys Ile Leu Leu Asn Val Gln Glu Glu Val Thr Cys Pro 
1               5                   10                  15


Ile Cys Leu Glu Leu Leu Thr Glu Pro Leu Ser Leu Asp Cys Gly His 
            20                  25                  30


Ser Leu Cys Arg Ala Cys Ile Thr Val Ser Asn Lys Glu Ala Val Thr 
        35                  40                  45


Ser Met Gly Gly Lys Ser Ser Cys Pro Val Cys Gly Ile Ser Tyr Ser 
    50                  55                  60


Phe Glu His Leu Gln Ala Asn Gln His Leu Ala Asn Ile Val Glu Arg 
65                  70                  75                  80


Leu Lys Glu Val Lys Leu Ser Pro Asp Asn Gly Lys Lys Arg Asp Leu 
                85                  90                  95


Cys Asp His His Gly Glu Lys Leu Leu Leu Phe Cys Lys Glu Asp Arg 
            100                 105                 110


Lys Val Ile Cys Trp Leu Cys Glu Arg Ser Gln Glu His Arg Gly His 
        115                 120                 125


His Thr Val Leu Thr Glu Glu Val Phe Lys Glu Cys Gln Glu Lys Leu 
    130                 135                 140


Gln Ala Val Leu Lys Arg Leu Lys Lys Glu Glu Glu Glu Ala Glu Lys 
145                 150                 155                 160


Leu Glu Ala Asp Ile Arg Glu Glu Lys Thr Ser Trp Lys Tyr Gln Val 
                165                 170                 175


Gln Thr Glu Arg Gln Arg Ile Gln Thr Glu Phe Asp Gln Leu Arg Ser 
            180                 185                 190


Ile Leu Asn Asn Glu Glu Gln Arg Glu Leu Gln Arg Leu Glu Glu Glu 
        195                 200                 205


Glu Lys Lys Thr Leu Asp Lys Phe Ala Glu Ala Glu Asp Glu Leu Val 
    210                 215                 220


Gln Gln Lys Gln Leu Val Arg Glu Leu Ile Ser Asp Val Glu Cys Arg 
225                 230                 235                 240


Ser Gln Trp Ser Thr Met Glu Leu Leu Gln Asp Met Ser Gly Ile Met 
                245                 250                 255


Lys Trp Ser Glu Ile Trp Arg Leu Lys Lys Pro Lys Met Val Ser Lys 
            260                 265                 270


Lys Leu Lys Thr Val Phe His Ala Pro Asp Leu Ser Arg Met Leu Gln 
        275                 280                 285


Met Phe Arg Glu Leu Thr Ala Val Arg Cys Tyr Trp Val Asp Val Thr 
    290                 295                 300


Leu Asn Ser Val Asn Leu Asn Leu Asn Leu Val Leu Ser Glu Asp Gln 
305                 310                 315                 320


Arg Gln Val Ile Ser Val Pro Ile Trp Pro Phe Gln Cys Tyr Asn Tyr 
                325                 330                 335


Gly Val Leu Gly Ser Gln Tyr Phe Ser Ser Gly Lys His Tyr Trp Glu 
            340                 345                 350


Val Asp Val Ser Lys Lys Thr Ala Trp Ile Leu Gly Val Tyr Cys Arg 
        355                 360                 365


Thr Tyr Ser Arg His Met Lys Tyr Val Val Arg Arg Cys Ala Asn Arg 
    370                 375                 380


Gln Asn Leu Tyr Thr Lys Tyr Arg Pro Leu Phe Gly Tyr Trp Val Ile 
385                 390                 395                 400


Gly Leu Gln Asn Lys Cys Lys Tyr Gly Val Phe Glu Glu Ser Leu Ser 
                405                 410                 415


Ser Asp Pro Glu Val Leu Thr Leu Ser Met Ala Val Pro Pro Cys Arg 
            420                 425                 430


Val Gly Val Phe Leu Asp Tyr Glu Ala Gly Ile Val Ser Phe Phe Asn 
        435                 440                 445


Val Thr Ser His Gly Ser Leu Ile Tyr Lys Phe Ser Lys Cys Cys Phe 
    450                 455                 460


Ser Gln Pro Val Tyr Pro Tyr Phe Asn Pro Trp Asn Cys Pro Ala Pro 
465                 470                 475                 480


Met Thr Leu Cys Pro Pro Ser Ser 
                485


<210>  863
<211>  2222
<212>  DNA
<213>  Homo sapiens

<400>  863
accctggctt ttcttcacct cttcaaccag gagccgagat ttctgttgct ctgaagccat     60

ccaggggtct ttaaccagaa gagagaggag agcctcagga gttaggacca gaagaagcca    120

gggaagcagt gcaatggctt caaaaatctt gcttaacgta caagaggagg tgacctgtcc    180

catctgcctg gagctgttga cagaaccctt gagtctagac tgtggccaca gcctctgccg    240

agcctgcatc actgtgagca acaaggaggc agtgaccagc atgggaggaa aaagcagctg    300

tcctgtgtgt ggtatcagtt actcatttga acatctacag gctaatcagc atctggccaa    360

catagtggag agactcaagg aggtcaagtt gagcccagac aatgggaaga agagagatct    420

ctgtgatcat catggagaga aactcctact cttctgtaag gaggatagga aatattcaag    480

gaatgtcagg agaaactcca ggcagtcctc aagaggctga agaaggaaga ggaggaagct    540

gagaagctgg aagctgacat cagagaagag aaaacttcct ggaagtatca ggtacaaact    600

gagagacaaa ggatacaaac agaatttgat cagcttagaa gcatcctaaa taatgaggag    660

cagagagagc tgcaaagatt ggaagaagaa gaaaagaaga cgctggataa gtttgcagag    720

gctgaggatg agctagttca gcagaagcag ttggtgagag agctcatctc agatgtggag    780

tgtcggagtc agtggtcaac aatggagctg ctgcaggaca tgagtggaat catgaaatgg    840

agtgagatct ggaggctgaa aaagccaaaa atggtttcca agaaactgaa gactgtattc    900

catgctccag atctgagtag gatgctgcaa atgtttagag aactgacagc tgtccggtgc    960

tactgggtgg atgtcacact gaattcagtc aacctaaatt tgaatcttgt cctttcagaa   1020

gatcagagac aagtgatatc tgtgccaatt tggccttttc agtgttataa ttatggtgtc   1080

ttgggatccc aatatttctc ctctgggaaa cattactggg aagtggacgt gtccaagaaa   1140

actgcctgga tcctgggggt atactgtaga acatattccc gccatatgaa gtatgttgtt   1200

agaagatgtg caaatcgtca aaatctttac accaaataca gacctctatt tggctactgg   1260

gttatagggt tacagaataa atgtaagtat ggtgtctttg aagagtcttt gtcctctgat   1320

cccgaggttt tgactctctc catggctgtg cctccctgcc gtgttggggt tttcctcgac   1380

tatgaagcag gcattgtctc atttttcaat gtcacaagcc atggctccct catttacaag   1440

ttctctaaat gttgcttttc tcagcctgtt tatccatatt tcaatccttg gaactgtcca   1500

gctcccatga ctctatgccc accaagctct tgaattttct catttcttca cctacaaccc   1560

tttgtcttga cttatctcct gcaactgact catctgcaac attcacacca ttgcttcctt   1620

gtggtttccc ttctttagaa cttttactca tccttgagat gtatggtgta tttggcttga   1680

gttatgagag atgcttattt attcatttac tctttttcat attttcagag aaagttacct   1740

aatccctcct aaagacacag cagtatgggt ataacatcct tgccttccca tttatccatg   1800

tttcacttta tcactgatat gaagaggccc aaagcctgtt agccaccatc catgctacct   1860

aggtagtcca taggaaccac ccccatgacc accaccaaca tcaactaaag gttcttggag   1920

ggtatgtcag tgtgttgctc aggatacccc aggtacatca aggaatcaag gagaggaaaa   1980

tatgagcaat atgtgtattc agagtgaaga ttttatgtcc agagtatttg agctcaaacc   2040

ttgcctgttg ttttctaatc atgatgaata ctttctcagt ttctttttcc tgaaatataa   2100

attgggattt aagactgtac ctaactatta agatcactgt gtaaaactaa gtgtctctaa   2160

atgtaatgca tcgatttagt gtctggaaca taataaatat ttgctctcat gattgctaaa   2220

aa                                                                  2222


<210>  864
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  864

Met Glu Leu Leu Gln Asp Met Ser Gly Ile Met Lys Trp Ser Glu Ile 
1               5                   10                  15


Trp Arg Leu Lys Lys Pro Lys Met Val Ser Lys Lys Leu Lys Thr Val 
            20                  25                  30


Phe His Ala Pro Asp Leu Ser Arg Met Leu Gln Met Phe Arg Glu Leu 
        35                  40                  45


Thr Ala Val Arg Cys Tyr Trp Val Asp Val Thr Leu Asn Ser Val Asn 
    50                  55                  60


Leu Asn Leu Asn Leu Val Leu Ser Glu Asp Gln Arg Gln Val Ile Ser 
65                  70                  75                  80


Val Pro Ile Trp Pro Phe Gln Cys Tyr Asn Tyr Gly Val Leu Gly Ser 
                85                  90                  95


Gln Tyr Phe Ser Ser Gly Lys His Tyr Trp Glu Val Asp Val Ser Lys 
            100                 105                 110


Lys Thr Ala Trp Ile Leu Gly Val Tyr Cys Arg Thr Tyr Ser Arg His 
        115                 120                 125


Met Lys Tyr Val Val Arg Arg Cys Ala Asn Arg Gln Asn Leu Tyr Thr 
    130                 135                 140


Lys Tyr Arg Pro Leu Phe Gly Tyr Trp Val Ile Gly Leu Gln Asn Lys 
145                 150                 155                 160


Cys Lys Tyr Gly Val Phe Glu Glu Ser Leu Ser Ser Asp Pro Glu Val 
                165                 170                 175


Leu Thr Leu Ser Met Ala Val Pro Pro Cys Arg Val Gly Val Phe Leu 
            180                 185                 190


Asp Tyr Glu Ala Gly Ile Val Ser Phe Phe Asn Val Thr Ser His Gly 
        195                 200                 205


Ser Leu Ile Tyr Lys Phe Ser Lys Cys Cys Phe Ser Gln Pro Val Tyr 
    210                 215                 220


Pro Tyr Phe Asn Pro Trp Asn Cys Pro Ala Pro Met Thr Leu Cys Pro 
225                 230                 235                 240


Pro Ser Ser 



<210>  865
<211>  959
<212>  DNA
<213>  Homo sapiens

<400>  865
ccatccaggg gtctttaacc agaagagaga ggagagcctc aggagttagg accagaagaa     60

gccagggaag cagtgcaatg gcttcaaaaa tcttgcttaa cgtacaagag gaggtgacct    120

gtcccatctg cctggagctg ttgacagaac ccttgagtct agactgtggc cacagcctct    180

gccgagcctg catcactgtg agcaacaagg aggcagtgac cagcatggga ggaaaaagca    240

gctgtcctgt gtgtggtatc agttactcat ttgaacatct acaggctaat cagcatctgg    300

ccaacatagt ggagagactc aaggaggtca agttgagccc agacaatggg aagaagagag    360

atctctgtga tcatcatgga gagaaactcc tactcttctg taaggaggat aggaaagtca    420

tttgctggct ttgtgagcgg tctcaggagc accgtggtca ccacacagtc ctcacggagg    480

aagtattcaa ggaatgtcag gagaaactcc aggcagtcct caagaggctg aagaaggaag    540

aggaggaagc tgagaagctg gaagctgaca tcagagaaga gaaaacttcc tggaagtatc    600

aggtacaaac tgagagacaa aggatacaaa cagaatttga tcagcttaga agcatcctaa    660

ataatgagga gcagagagag ctgcaaagat tggaagaaga agaaaagaag acgctggata    720

agtttgcaga ggctgaggat gagctagttc agcagaagca gttggtgaga gagctcatct    780

cagatgtgga gtgtcggagt cagtggtcaa caatggagct gctgcaggac atgagtggaa    840

tcatgaaatg gtgcgtatgg gtggccagga gtggtgcttg tgagttataa agaagtgttt    900

gtagctatta gagttatttg gtggtcaatt ggaataaaaa atctcccaga gtagtaaaa     959


<210>  866
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  866

Met Ala Ser Lys Ile Leu Leu Asn Val Gln Glu Glu Val Thr Cys Pro 
1               5                   10                  15


Ile Cys Leu Glu Leu Leu Thr Glu Pro Leu Ser Leu Asp Cys Gly His 
            20                  25                  30


Ser Leu Cys Arg Ala Cys Ile Thr Val Ser Asn Lys Glu Ala Val Thr 
        35                  40                  45


Ser Met Gly Gly Lys Ser Ser Cys Pro Val Cys Gly Ile Ser Tyr Ser 
    50                  55                  60


Phe Glu His Leu Gln Ala Asn Gln His Leu Ala Asn Ile Val Glu Arg 
65                  70                  75                  80


Leu Lys Glu Val Lys Leu Ser Pro Asp Asn Gly Lys Lys Arg Asp Leu 
                85                  90                  95


Cys Asp His His Gly Glu Lys Leu Leu Leu Phe Cys Lys Glu Asp Arg 
            100                 105                 110


Lys Val Ile Cys Trp Leu Cys Glu Arg Ser Gln Glu His Arg Gly His 
        115                 120                 125


His Thr Val Leu Thr Glu Glu Val Phe Lys Glu Cys Gln Glu Lys Leu 
    130                 135                 140


Gln Ala Val Leu Lys Arg Leu Lys Lys Glu Glu Glu Glu Ala Glu Lys 
145                 150                 155                 160


Leu Glu Ala Asp Ile Arg Glu Glu Lys Thr Ser Trp Lys Tyr Gln Val 
                165                 170                 175


Gln Thr Glu Arg Gln Arg Ile Gln Thr Glu Phe Asp Gln Leu Arg Ser 
            180                 185                 190


Ile Leu Asn Asn Glu Glu Gln Arg Glu Leu Gln Arg Leu Glu Glu Glu 
        195                 200                 205


Glu Lys Lys Thr Leu Asp Lys Phe Ala Glu Ala Glu Asp Glu Leu Val 
    210                 215                 220


Gln Gln Lys Gln Leu Val Arg Glu Leu Ile Ser Asp Val Glu Cys Arg 
225                 230                 235                 240


Ser Gln Trp Ser Thr Met Glu Leu Leu Gln Asp Met Ser Gly Ile Met 
                245                 250                 255


Lys Trp Cys Val Trp Val Ala Arg Ser Gly Ala Cys Glu Leu 
            260                 265                 270


<210>  867
<211>  1276
<212>  DNA
<213>  Homo sapiens

<400>  867
cttgtccttt cagaagatca gagacaagtg atatctgtgc caatttggcc ttttcagtgt     60

tataattatg gtgtcttggg atcccaatat ttctcctaat gtttccctga tgtgatactt    120

tgagagccca ggatgccagt acaataattg aaattcacaa atgtctggta tcttgtccct    180

cgtgccccat atattatctg tggtttcgga gagctcactt gtctcttatc ttcagaaatg    240

acagcacatg aaatgttgtt tggagccact gtcacatcaa ctgtagaaaa attaacaggt    300

cagctaaggg atataatgta actttatttg tgatatgaga gaaatcttga taaagacttg    360

agagaaaact gggaggaacc ttgtttagaa gttataagga ggggtaagtt atgtgtgtct    420

tggaaggaga atcataaatc ttaaaacatg agcctaatag agaacataaa attctaaaag    480

ataaagataa taataatgat aagccgcagg gtggcttatg ataatgtgac ttctccttac    540

cccagtagcg tcggacatct gtcagctctg aaatgataaa aatgcacaat attgaataca    600

aacaaaggag tcagcactga aattcatttt ctctccagat tagggaaaga gtaggtatgc    660

cctatggtag ggcagtaaat tgctgaatga tgagatgaaa cagccaccta gccatttccc    720

attaaatata atcccatcag cagcagacaa tatctatcct cccctatccc ctctatccat    780

atttggaaac tgcaccctct tccctattta gcaccctaac accacttgaa ttccataacc    840

ctgttgttga tctagctctc ctcacctcta aacacttcta gcattccttt cagatcagga    900

gctcgaaaca ctctcctttg attttttgga aaagtttctg gcttcttcaa ggtcacgttc    960

tccgtcctaa gaattaaaaa aaaaaaaaaa acttccaaac ctttgacctt gtgtccgtgg   1020

aacacccctg acttcctatc atttcaaccc attgaggcac ttgaactctc ttcttgggga   1080

tcctgagaag ggagagtgca aactcttgac cctggaggca aacaaaatgt tctcatgttt   1140

gccttcccac ttactttctg cgagaacgtg ggaagatctt aacctctcag aagcacagtt   1200

tcttccttct aaaatgaaat aattaacctc tccctgtcta cattcttaaa ctcataggac   1260

ataaaaaaaa aaaaaa                                                   1276


<210>  868
<211>  2364
<212>  DNA
<213>  Homo sapiens

<400>  868
gtcatcgctg tctggaacag cgatgactcg atcgcgagat caggaaggtg gccgagtgtg     60

tcgccgcggc catcaggcac ttctccttcc tgcccttgta tgaagaagga tgtgtttgct    120

tccccttgtg ccatgattgt aaatttcctg aggcctcctc agccctgcag aactggggtt    180

atagccatgt gactgatctt cgtccaagaa tatgtaaaga aaaagtgttg agttggcttt    240

tagggctaga gcaatgtatc ttaggctcac ttaaggaagc tgtagagatg agcccaagga    300

gggaaaccag aagagccccc caggctcacc agttgtttgt tggctcccta caaacatgtc    360

attcaagtgg ctaatcttac aacagcacaa attcatctaa ccagaaagag aagaggaggc    420

tccaaaggca cttgactact gagcatcacc ctggacgtgt acaagtctgc gtccttattg    480

ttttcttcat tgggccgaac tttctggtcc tcatccaaca gctcttctat cacgtgttcg    540

aaagtgtcag ccaatgatgt caagcatctt gaacctgcct tgggcccatt cacgctctcc    600

agagtcccat gggtccgcac acctggagat actctattat agcaaagaag aaagataatt    660

tcattgagcc atcctgtttt acagtattga attattacca caaggtacca accatatatg    720

catacttaat agggtatttt gtcaaaacta tgcatgaagg tcatttgttt gagatgtcag    780

aacattttcc cgtgagaaga tctcattggg cattgaaaca gaaccacatg ctcttcagac    840

cagcaaccgc gactaccaaa tactcctctg tcaactctac ttgagtaaga acgctttcaa    900

ttaaggccta agtgtcaaca tgcctttaaa aaaaatcgtg gtgacacaaa atctttcttt    960

ttagcaccca acagaatccc ttcaaagcct cgtggtctga caccctatgc tacgtgactt   1020

gtgacccatc catttgtcat gttcttcggg aatgtggcta aggggctaag atgtgacttg   1080

aaaagaaagg tagaacaaga tcatctcaaa tttattatca aggaatagtt cagaaaacga   1140

cttcagacca cagagacagc agaacagatg gtccggcatg gatagagcat cagacactca   1200

cagactgtgc caacaagagc catcgagtca aaacagccaa aggaaggagg gtcatggaat   1260

gggttctctc acaccaaact gatgcccaga ggccctcagc atgaataaca aaggcaacca   1320

gacccacaag ccatactgag tggatacaaa acctatacct aggctgacat cccaaatgtg   1380

tgtggcaagt tagatgatga tggcacaaaa gacagaacac cttgcttctg gccattgtca   1440

gctcttggaa gagagcacac ttttagagga gcagctgcaa ggagcctgag aacaaaactg   1500

gaaatgtctg ttatgaaagc cttcacagga aattctgcaa gtggcaacgt gggtccattc   1560

cgtgtgtgtc actagagctg gcgcaagccc atggccatgg tgaggcagcg tttccactgg   1620

aactaatctg atacctgcac caactcttgc aactgtgcag tgttcccact gcaaactacg   1680

gatggggtaa aagactgctc acctcctatt tctcatctaa tctcacacac tctgtttgat   1740

gaggctatgg agaaacaggt cttctcatac actaaaggtg ggagtacaaa caattcaagc   1800

cctgtgcagg acaattaggc aatacctatc aaaattatac atgatttttc ctgctgaccc   1860

agcaattcca cttttgggaa taattgacag atataggtgc atatgtacaa aatgatggaa   1920

agctctctgg tatatattag taagtgataa aacaaggtgt aaaatagtgt atatatggct   1980

actacctttt gttttaaaaa tgggggaaaa tggtggagct tgcggtgagc cgagatcgtg   2040

ccactgcact ccagcctggg cgacagagcg agactccgtc tcaaaaaaaa aacagggtgg   2100

ggtggggggg aaataatagt acatactcat atttacctgt atctatataa aacacactat   2160

caaggattca caagaaacta atacaaatga tccccttata gatggtatgt attgggggat   2220

actgaggtga gcagggtata agtggggcaa gacttttcag tgtaaacttc ttttaaattt   2280

tattttgatt tttgaataat gtaaattaac tgtcaaataa ttaaattaaa aataaccaat   2340

ttattaacaa aaaaaaaaaa aaaa                                          2364


<210>  869
<211>  2068
<212>  DNA
<213>  Homo sapiens

<400>  869
agtgttggcc aatcccagca gccatacttc aactactcat agactgctga atgttcaaac     60

tgtgttcaaa taagatggtg tcacaagaag gatctgaagt ggagcttcta gtatccccag    120

gagcgcgaag tgaacacgga aggtacctgc aggatccaat tgtgtccatt gatctctcag    180

agtggctgag gataatagag tttcttcttc aaggtctcaa ggtgtatggc tctgtgtatc    240

acatcaatca cgggaacccc ttcaacatgg aggtgctggt ggattcctgg cctgaatatc    300

agatggttat tatccggcct caaaagcagg agatgactga tgacatggat tcatacacaa    360

acgtatatcg tatgttctcc aaagagcctc aaaaatcaga agaagttttg aaaaattgtg    420

agatcgtaaa ctggaaacag agactccaaa tccaaggtct tcaagaaagt ttaggtgagg    480

ggataagagt ggctacattt tcaaagtcag tgaaagtaga gcattcgaga gcactcctct    540

tggttacgga agatattctg aagctcaatg cctccagtaa aagcaagctt ggaagctggg    600

ctgagacagg ccacccagat gatgaatttg aaagtgaaac tcccaacttt aagtatgccc    660

agctggatgt ctcttattct gggctggtaa atgacaactg gaagcgaggg aagaatgaga    720

ggagcctgca ttacatcaag cgctgcatag aagacctgcc agcagcctgt atgctcggcc    780

cagagggagt cccggtctca tgggtaacca tggacccttc ttgtgaagta ggaatggcct    840

acagcatgga aaaataccga aggacaggca acatggcacg agtgatggtg cgatacatga    900

aatatctgcg tcagaagaat attccatttt acatctctgt gttggaagaa aatgaagact    960

cccgcagatt tgtggggcag tttggtttct ttgaggcctc ctgtgagtgg caccaatgga   1020

cttgctaccc acagaatcta gttccatttt agacaatgaa gctgcttagt aatctctgcc   1080

aagccatctc ttaatattaa agcagacacc acagaataga tttcttcact tacaaatgca   1140

tattgggcac ttataataca gcaggaactc ttctcacctg gagccttgat gttaaaagac   1200

acagccatgc tcttgaggag cttacaatcc tggctggagg caggggaggg tatattcttt   1260

aaatatgctt aagtgttata gggaaagacg gggttaccag taaacatgta actagaaagc   1320

caggctcagt tcttacctct gggaatcaga actctttatg caacttggtt aatagaatct   1380

actatctgga agataaatga aggattttaa taaaattttc aatagaataa acctaatctg   1440

tatggatact ttatcaaaaa tgaatgtccc tgctatttct ggatttatga ggcaatggta   1500

cactaaagaa tggaatcagt tcagtgagta gaaaggtatc caaggtgaag cctgagacga   1560

atggctttcc caggctacct tccatcactg ttgtacagaa aagaaatcca gagaatcaaa   1620

tggactggcc ttgggggtct ctgctatgga aatgccattt tttgtgtctc ctttctccta   1680

ctctttctca catcctcttc atgattgaag catggcacaa ggcaaggtgt tgcctgcgag   1740

tctggttgta agttcagcct ttggtgtttg cactactgct atcataaggg gtcagggaca   1800

ttccggggag aagtgaccac taaggtgagg attagagagt gagtagaagt gagccagaca   1860

aaaaaagcag aaaatgcaga tgatggaaag gacatgtgcc atgcactatc ataagaactt   1920

cctaactgaa cactgatact acaattctga atccctgatc ttaaaaaata attatacttc   1980

accaacaaaa cttggcctct tttggttcca ctctgccacc ctgccattgg aacttggatt   2040

actgtgaaca ttgcagctat agcaaaat                                      2068


<210>  870
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  870

Met Phe Lys Leu Cys Ser Asn Lys Met Val Ser Gln Glu Gly Ser Glu 
1               5                   10                  15


Val Glu Leu Leu Val Ser Pro Gly Ala Arg Ser Glu His Gly Arg Tyr 
            20                  25                  30


Leu Gln Asp Pro Ile Val Ser Ile Asp Leu Ser Glu Trp Leu Arg Ile 
        35                  40                  45


Ile Glu Phe Leu Leu Gln Gly Leu Lys Val Tyr Gly Ser Val Tyr His 
    50                  55                  60


Ile Asn His Gly Asn Pro Phe Asn Met Glu Val Leu Val Asp Ser Trp 
65                  70                  75                  80


Pro Glu Tyr Gln Met Val Ile Ile Arg Pro Gln Lys Gln Glu Met Thr 
                85                  90                  95


Asp Asp Met Asp Ser Tyr Thr Asn Val Tyr Arg Met Phe Ser Lys Glu 
            100                 105                 110


Pro Gln Lys Ser Glu Glu Val Leu Lys Asn Cys Glu Ile Val Asn Trp 
        115                 120                 125


Lys Gln Arg Leu Gln Ile Gln Gly Leu Gln Glu Ser Leu Gly Glu Gly 
    130                 135                 140


Ile Arg Val Ala Thr Phe Ser Lys Ser Val Lys Val Glu His Ser Arg 
145                 150                 155                 160


Ala Leu Leu Leu Val Thr Glu Asp Ile Leu Lys Leu Asn Ala Ser Ser 
                165                 170                 175


Lys Ser Lys Leu Gly Ser Trp Ala Glu Thr Gly His Pro Asp Asp Glu 
            180                 185                 190


Phe Glu Ser Glu Thr Pro Asn Phe Lys Tyr Ala Gln Leu Asp Val Ser 
        195                 200                 205


Tyr Ser Gly Leu Val Asn Asp Asn Trp Lys Arg Gly Lys Asn Glu Arg 
    210                 215                 220


Ser Leu His Tyr Ile Lys Arg Cys Ile Glu Asp Leu Pro Ala Ala Cys 
225                 230                 235                 240


Met Leu Gly Pro Glu Gly Val Pro Val Ser Trp Val Thr Met Asp Pro 
                245                 250                 255


Ser Cys Glu Val Gly Met Ala Tyr Ser Met Glu Lys Tyr Arg Arg Thr 
            260                 265                 270


Gly Asn Met Ala Arg Val Met Val Arg Tyr Met Lys Tyr Leu Arg Gln 
        275                 280                 285


Lys Asn Ile Pro Phe Tyr Ile Ser Val Leu Glu Glu Asn Glu Asp Ser 
    290                 295                 300


Arg Arg Phe Val Gly Gln Phe Gly Phe Phe Glu Ala Ser Cys Glu Trp 
305                 310                 315                 320


His Gln Trp Thr Cys Tyr Pro Gln Asn Leu Val Pro Phe 
                325                 330


<210>  871
<211>  1568
<212>  DNA
<213>  Homo sapiens

<400>  871
cttaatattc acttttaatt cattccacca gagaggaaat gcatgggttt tggataggac     60

tctgtcattt atccctgtaa gaacttgaga aatttattta gtctctctaa gctttggcgt    120

attcaaaatg aagacgatac taacagtacc tacatcatga gtgttacttg aatggagatg    180

tgtaaagtgc attttaattt catctggtcc tttaacattt tcccttcact tctcttcaga    240

gttttttctt gaagggctcg aggactgaag catcccacaa aatgattcta ttgaataatt    300

ctgagcagct gctggcccta ttcaaatctt tagcaaggag cattcctgag tccctgaagg    360

tgtatggctc tctgtttcac atcaatcacg ggaacccctt caacatggag gtgttggtgg    420

actcctggcc cgggtatcag atggttatta tccgacctca aaaacaggag atgactgatg    480

acatggattc atacactaat gtatatcgta tattctccaa agaccctcaa aaatcacaag    540

aagttttgaa aaattctgag atcataaact ggaaacagaa actccaaatc caaggttttc    600

aagaaagttt aggtgagggg ataaaagcag ctgcattttc aaattcagtg aaggtagagc    660

attcgagagc actcctcttt gttacggaag atatcctgaa gctctatgcc accaataaaa    720

gcaagcttgg aagctgggct gagacaggcc acccagatga cgaattggag agcgagactc    780

ccaattttaa gtatgcccag ctgaatgtgt cttattctgg gctggtaaat gacaactgga    840

agctagggat gaataagagg agcctgcatt acatcaagcg ctgcctagga gccctgccag    900

cagtctgtat gctgggccca gagggggtcc cggtctcatg ggtaaccatg gacccttctt    960

gtgaaatagg aatgggctac agtgtggaaa aataccgaag gagaggcaac gcgacacgga   1020

tgatggtgcg atacatgaag tatctgtgtc agaagaatat tccattttac ggctctgtgc   1080

tggaagaaaa tcaaggcgcc atcagaatga ataaggcact aggtttcctt gaggcctcct   1140

gtcagtggca ccaatggacc tgctacccac agaatcttgt tccgttgtag acaatgaagc   1200

tgcttagcaa tcttgggcaa gccatctctt aatattaaag cagacaccac agaatagctt   1260

tcttcactta caaatgttga ttgggcattt atgatatggc aggaactcct tctcacatgg   1320

agacctgatg ttaaaggaca cagccatgct cttgaggagc ttacaatcca agctggaggc   1380

aggggagggt atagtcttta aatatgctta agtgttgtag ggaaggacag agttaccaat   1440

aaacatgtaa ctagaaagcc aggctcagtt cttacctctg ggaatcagaa ctctttatga   1500

aacttgattg atagaatcta ctatctggaa gataattgaa gaactttaat aaaattgtca   1560

atagaata                                                            1568


<210>  872
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  872

Met Ile Leu Leu Asn Asn Ser Glu Gln Leu Leu Ala Leu Phe Lys Ser 
1               5                   10                  15


Leu Ala Arg Ser Ile Pro Glu Ser Leu Lys Val Tyr Gly Ser Leu Phe 
            20                  25                  30


His Ile Asn His Gly Asn Pro Phe Asn Met Glu Val Leu Val Asp Ser 
        35                  40                  45


Trp Pro Gly Tyr Gln Met Val Ile Ile Arg Pro Gln Lys Gln Glu Met 
    50                  55                  60


Thr Asp Asp Met Asp Ser Tyr Thr Asn Val Tyr Arg Ile Phe Ser Lys 
65                  70                  75                  80


Asp Pro Gln Lys Ser Gln Glu Val Leu Lys Asn Ser Glu Ile Ile Asn 
                85                  90                  95


Trp Lys Gln Lys Leu Gln Ile Gln Gly Phe Gln Glu Ser Leu Gly Glu 
            100                 105                 110


Gly Ile Lys Ala Ala Ala Phe Ser Asn Ser Val Lys Val Glu His Ser 
        115                 120                 125


Arg Ala Leu Leu Phe Val Thr Glu Asp Ile Leu Lys Leu Tyr Ala Thr 
    130                 135                 140


Asn Lys Ser Lys Leu Gly Ser Trp Ala Glu Thr Gly His Pro Asp Asp 
145                 150                 155                 160


Glu Leu Glu Ser Glu Thr Pro Asn Phe Lys Tyr Ala Gln Leu Asn Val 
                165                 170                 175


Ser Tyr Ser Gly Leu Val Asn Asp Asn Trp Lys Leu Gly Met Asn Lys 
            180                 185                 190


Arg Ser Leu His Tyr Ile Lys Arg Cys Leu Gly Ala Leu Pro Ala Val 
        195                 200                 205


Cys Met Leu Gly Pro Glu Gly Val Pro Val Ser Trp Val Thr Met Asp 
    210                 215                 220


Pro Ser Cys Glu Ile Gly Met Gly Tyr Ser Val Glu Lys Tyr Arg Arg 
225                 230                 235                 240


Arg Gly Asn Ala Thr Arg Met Met Val Arg Tyr Met Lys Tyr Leu Cys 
                245                 250                 255


Gln Lys Asn Ile Pro Phe Tyr Gly Ser Val Leu Glu Glu Asn Gln Gly 
            260                 265                 270


Ala Ile Arg Met Asn Lys Ala Leu Gly Phe Leu Glu Ala Ser Cys Gln 
        275                 280                 285


Trp His Gln Trp Thr Cys Tyr Pro Gln Asn Leu Val Pro Leu 
    290                 295                 300


<210>  873
<211>  1568
<212>  DNA
<213>  Homo sapiens

<400>  873
cttaatattc acttttattc attccaccag agaggaaatg catgggtttt ggatatgact     60

ctgtcgttta tccctgtaag aacttgagaa atttatttag tctctctaag ctttggcgta    120

ttcaaaatga agacgatact aacagtacct acatcatgag tgttacttga atggagatgt    180

gtaaagtgca ttttaatttc atctggtcct ttaacatttt ccctccactt ctcttcagag    240

tttttttctt gaagggcttg aggactgaag catcccacaa aatgattcta ttgaataatt    300

ccgagcggct gctggcccta ttcaaatctt tagcaaggag cattcctgag tccctgaagg    360

tgtatggctc tctgtttcac atcaatcacg ggaacccctt caacatggaa gtgttggtgg    420

actcctggcc cgagtatcag atggttatta tccgacctca aaaacaggag atgactgatg    480

acatggattc atacactaat gtatatcgtg tattctccaa agaccctcaa aaatcacaag    540

aagttttgaa aaattctgag atcataaact ggaaacagaa actccaaatc caaggttttc    600

aagaaagttt aggtgagggg ataagagcag ctgcattttc aaattcagtg aaggtagagc    660

attcgagagc actcctcttt gttacggaag atatcctgaa gctctatgcc accaataaaa    720

gcaagcttgg aagctgggct gagacaggcc acccagatga cgaattggag agcgagactc    780

cgaactttaa gtatgcccag ctgaatgtgt cttattctgg gctggtaaat gacaactgga    840

agctagggat gaataagagg agcctgcgtt acatcaagcg ctgcctagga gccctgccag    900

cagcctgtat gctgggccca gagggggtcc cggtctcatg ggtaaccatg gacccttctt    960

gtgaaatagg aatgggctac agtgtggaaa aataccgaag gagaggcaat gggacacggc   1020

tgatcatgcg atgcatgaag tatctgtgtc agaagaatat tccattttac ggctctgtgc   1080

tggaagaaaa tcaaggcgtc atcagaaaga ctagtgcact aggtttcctt gaggcctcct   1140

gtcagtggca ccaatggaac tgctacccac agaatcttgt tccattgtag acaatgaagc   1200

tgcttagcaa tcttgggcaa gccatctctt aatattaaag cagacaccac agaatagctt   1260

tcttcactta caaatgttga ttgggcattt gtgatatggc aggaactctt tctcacatgg   1320

agacttgatg ttaaaggaca cagccatgct cttgaggagc ttacaatcca agctggaggc   1380

aggggagggt atagtcttta aatatgctta agtgttgtag ggaaggacag agttaccaat   1440

aaacatgtaa ctagaaagcc aggctcagtt cttacctctg ggaatcagaa ctctttatga   1500

aacttggttg atagaatcta ctatctggaa gataaatgaa gaactttaat aaaattgtca   1560

atagaata                                                            1568


<210>  874
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  874

Met Ile Leu Leu Asn Asn Ser Glu Arg Leu Leu Ala Leu Phe Lys Ser 
1               5                   10                  15


Leu Ala Arg Ser Ile Pro Glu Ser Leu Lys Val Tyr Gly Ser Leu Phe 
            20                  25                  30


His Ile Asn His Gly Asn Pro Phe Asn Met Glu Val Leu Val Asp Ser 
        35                  40                  45


Trp Pro Glu Tyr Gln Met Val Ile Ile Arg Pro Gln Lys Gln Glu Met 
    50                  55                  60


Thr Asp Asp Met Asp Ser Tyr Thr Asn Val Tyr Arg Val Phe Ser Lys 
65                  70                  75                  80


Asp Pro Gln Lys Ser Gln Glu Val Leu Lys Asn Ser Glu Ile Ile Asn 
                85                  90                  95


Trp Lys Gln Lys Leu Gln Ile Gln Gly Phe Gln Glu Ser Leu Gly Glu 
            100                 105                 110


Gly Ile Arg Ala Ala Ala Phe Ser Asn Ser Val Lys Val Glu His Ser 
        115                 120                 125


Arg Ala Leu Leu Phe Val Thr Glu Asp Ile Leu Lys Leu Tyr Ala Thr 
    130                 135                 140


Asn Lys Ser Lys Leu Gly Ser Trp Ala Glu Thr Gly His Pro Asp Asp 
145                 150                 155                 160


Glu Leu Glu Ser Glu Thr Pro Asn Phe Lys Tyr Ala Gln Leu Asn Val 
                165                 170                 175


Ser Tyr Ser Gly Leu Val Asn Asp Asn Trp Lys Leu Gly Met Asn Lys 
            180                 185                 190


Arg Ser Leu Arg Tyr Ile Lys Arg Cys Leu Gly Ala Leu Pro Ala Ala 
        195                 200                 205


Cys Met Leu Gly Pro Glu Gly Val Pro Val Ser Trp Val Thr Met Asp 
    210                 215                 220


Pro Ser Cys Glu Ile Gly Met Gly Tyr Ser Val Glu Lys Tyr Arg Arg 
225                 230                 235                 240


Arg Gly Asn Gly Thr Arg Leu Ile Met Arg Cys Met Lys Tyr Leu Cys 
                245                 250                 255


Gln Lys Asn Ile Pro Phe Tyr Gly Ser Val Leu Glu Glu Asn Gln Gly 
            260                 265                 270


Val Ile Arg Lys Thr Ser Ala Leu Gly Phe Leu Glu Ala Ser Cys Gln 
        275                 280                 285


Trp His Gln Trp Asn Cys Tyr Pro Gln Asn Leu Val Pro Leu 
    290                 295                 300


<210>  875
<211>  3489
<212>  DNA
<213>  Homo sapiens

<400>  875
aaatccagag cggcgggcac tgacgggcac ttgcaccgtg tggacagact ctccggttct     60

ggggaaatcc agtccctgtt actccatttt ggccagaaat tcaagacatt tcaggtggca    120

gaataaattc aatccttgtt tctccatctt atcgagtagt agaagttagt tacattctct    180

ttgaactcat catgaattcc atgaagactg aagaaaacaa gtcatttagc gctatggaag    240

atgaccagag gactagacct gaagtttcaa aggatactgt catgaagcag acacatgctg    300

acacacctgt tgatcattgt ctatctggca taagaaagtg tagcagcacc tttaagctta    360

aaagtgaagt caacaagcat gaaacagccc ttgaaatgca gaatccaaat ttgaacaata    420

aagaatgttg tttcaccttt acgttgaatg gaaactccag aaaattagac cgtagtgtgt    480

ttacagcata tggtaaaccc agcgagagta tctactcagc cctgagtgct aatgactatt    540

tcagtgaaag gataaagaat cagtttaata agaacattat tgtttatgaa gaaaagacaa    600

tagatggaca tataaattta ggaatgcctc tcaagtgcct gcctagtgat tctcatttta    660

aaattacatt tggtcaaaga aagagtagca aagaagatgg acacatatta cgccaatgtg    720

aaaatccaaa catggaatgc attctttttc atgttgttgc tataggaagg acaagaaaga    780

agattgttaa gatcaacgaa cttcatgaaa aaggaagtaa actttgtatt tatgccttga    840

agggtgagac tattgaagga gccttatgca aggatggccg ttttcggtct gacataggtg    900

aatttgaatg gaaactaaag gaaggtcata agaaaattta tggaaaacag tccatggtgg    960

atgaagtatc tggaaaagtc ttagaaatgg acatttcaaa aaaaaaagca ttacaacaga   1020

aagatatcca taaaaaaatt aaacagaatg aaagtgccac tgatgaaatt aatcaccaga   1080

gtctgataca gtctaagaaa aaagtccaca aaccaaagaa agatggagag accaaagatg   1140

tagaacacag cagagagcaa attctcccac ctcaggatct aagccattat attaaagata   1200

aaactcgcca gacaattccc aggattagaa attattactt ttgtagtttg ccccgaaaat   1260

ataggcaaat aaactcacaa gttagacgga ggccgcatct gggtaggcgg tatgctatta   1320

atctggatgt ccaaaaggag gcaattaatc tcttaaagaa ttatcaaacg ttgaatgaag   1380

ccataatgca tcagtatccg aattttaaag aggaggcaca gtgggtaaga aaatattttc   1440

gggaagaaca aaagagaatg aatctttcac cagctaagca attcaacata tataaaaagg   1500

acttcggaaa aatgactgca aattctgttt cagttgcaac ctgcgaacag cttacatatt   1560

atagcaagtc agttgggttc atgcaatggg acaataatgg aaacacaggt aatgctactt   1620

gctttgtctt caatggtggt tatattttca cctgtcgaca tgttgtacat cttatggtgg   1680

gtaaaaacac acatccaagt ttgtggccag atataattag caaatgtgcg aaggtaacct   1740

tcacttatac agagttctgc cctactcctg acaattggtt ttccattgag ccatggctta   1800

aagtgtccaa tgaaaatcta gattatgcca ttttaaaact aaaagaaaat ggaaatgcgt   1860

ttcctccagg actatggcga cagatttctc ctcaaccatc tactggtttg atttatttaa   1920

ttggtcatcc tgaaggccag atcaagaaaa tagatggttg tactgtgatt cctctaaacg   1980

aacgattgaa aaaatatcca aacgattgtc aagatgggtt ggtagatctc tatgatacca   2040

ccagtaatgt atactgtatg tttacccaaa gaagtttcct atcagaggtt tggaacacac   2100

acacgcttag ttatgatact tgtttctctg atgggtcctc aggctcccca gtgtttaatg   2160

catctggcaa attggttgct ttgcatacct ttgggctttt ttatcaacga ggatttaatg   2220

tgcatgccct tattgaattt ggttattcta tggattctat tctttgtgat attaaaaaga   2280

caaatgagag cttgtataaa tcattaaatg atgagaaact tgagacctac gatgaagaga   2340

aaggtaaaca agagtcatca cttcaagatc atcagattga acccatggaa tgttagaaaa   2400

gagatgctgt cttcaagaaa atatgccaat aattcctggc aaagatttca tgacaaagac   2460

acttaaagca attgcaacaa aagtgaaaat tggcaaatga gacctaatta aatcttctgc   2520

acagcaaaag aaactatcaa cagggtaaac acacaaccta cggaatggga gaaaatattt   2580

gcaaactatg catacagcaa agatctaata ttcagaatcc attaggaact taaacagatt   2640

aacaagcaaa aaaaaacaag caaccccatt aaaaagtggg caaaggacat gaacaaacac   2700

ttttcaaaag aagatataca catggccaac aaggatatga aaaaatacct gatatcacta   2760

atcattagag aaatgcaaat caaaaaaatg ccatcacact aatcagaatg gctgttatta   2820

aaatgccaaa aaattacaga tgctggcgag gttgcagaga aaggggaatg cttatacact   2880

gctagtggga aaataaatta gttcagccat tgtggaaagc agttgggtga tttctaaaag   2940

aacttaaaac agctaccatt caagccagca atctcatgac tgggtatatg tccaaaggaa   3000

tataaattgt tctaccataa agacatgcac atatatgttc actgcagcac tattcacaat   3060

agcaaaacat gaaatcaacc taaatgccca tcaatggtag actggataaa gaaaatgtga   3120

cacatataca ccatagcata ctacacagcc ataaaaaagt acaagatcat gtgctttgca   3180

gcaacatgga tggaactgaa ggtcattatc ctaagcgaac taatgcagga acagaaagcc   3240

aagtaccaca tgttctctca taagtggaag ctaaatattg agtacacatg gacacaaaga   3300

agaaaacaac agatatgggg cctacttgag ggtggagggt gggaggaggg tgaagactga   3360

aaaactgcct atggggtact atgcttatta cctgggtgat gaaataatct gaacacaaaa   3420

ccctggtgac atgcagttta cctatataac aaaactgcac atggactctt aaacctaaat   3480

aaaagttta                                                           3489


<210>  876
<211>  734
<212>  PRT
<213>  Homo sapiens

<400>  876

Met Asn Ser Met Lys Thr Glu Glu Asn Lys Ser Phe Ser Ala Met Glu 
1               5                   10                  15


Asp Asp Gln Arg Thr Arg Pro Glu Val Ser Lys Asp Thr Val Met Lys 
            20                  25                  30


Gln Thr His Ala Asp Thr Pro Val Asp His Cys Leu Ser Gly Ile Arg 
        35                  40                  45


Lys Cys Ser Ser Thr Phe Lys Leu Lys Ser Glu Val Asn Lys His Glu 
    50                  55                  60


Thr Ala Leu Glu Met Gln Asn Pro Asn Leu Asn Asn Lys Glu Cys Cys 
65                  70                  75                  80


Phe Thr Phe Thr Leu Asn Gly Asn Ser Arg Lys Leu Asp Arg Ser Val 
                85                  90                  95


Phe Thr Ala Tyr Gly Lys Pro Ser Glu Ser Ile Tyr Ser Ala Leu Ser 
            100                 105                 110


Ala Asn Asp Tyr Phe Ser Glu Arg Ile Lys Asn Gln Phe Asn Lys Asn 
        115                 120                 125


Ile Ile Val Tyr Glu Glu Lys Thr Ile Asp Gly His Ile Asn Leu Gly 
    130                 135                 140


Met Pro Leu Lys Cys Leu Pro Ser Asp Ser His Phe Lys Ile Thr Phe 
145                 150                 155                 160


Gly Gln Arg Lys Ser Ser Lys Glu Asp Gly His Ile Leu Arg Gln Cys 
                165                 170                 175


Glu Asn Pro Asn Met Glu Cys Ile Leu Phe His Val Val Ala Ile Gly 
            180                 185                 190


Arg Thr Arg Lys Lys Ile Val Lys Ile Asn Glu Leu His Glu Lys Gly 
        195                 200                 205


Ser Lys Leu Cys Ile Tyr Ala Leu Lys Gly Glu Thr Ile Glu Gly Ala 
    210                 215                 220


Leu Cys Lys Asp Gly Arg Phe Arg Ser Asp Ile Gly Glu Phe Glu Trp 
225                 230                 235                 240


Lys Leu Lys Glu Gly His Lys Lys Ile Tyr Gly Lys Gln Ser Met Val 
                245                 250                 255


Asp Glu Val Ser Gly Lys Val Leu Glu Met Asp Ile Ser Lys Lys Lys 
            260                 265                 270


Ala Leu Gln Gln Lys Asp Ile His Lys Lys Ile Lys Gln Asn Glu Ser 
        275                 280                 285


Ala Thr Asp Glu Ile Asn His Gln Ser Leu Ile Gln Ser Lys Lys Lys 
    290                 295                 300


Val His Lys Pro Lys Lys Asp Gly Glu Thr Lys Asp Val Glu His Ser 
305                 310                 315                 320


Arg Glu Gln Ile Leu Pro Pro Gln Asp Leu Ser His Tyr Ile Lys Asp 
                325                 330                 335


Lys Thr Arg Gln Thr Ile Pro Arg Ile Arg Asn Tyr Tyr Phe Cys Ser 
            340                 345                 350


Leu Pro Arg Lys Tyr Arg Gln Ile Asn Ser Gln Val Arg Arg Arg Pro 
        355                 360                 365


His Leu Gly Arg Arg Tyr Ala Ile Asn Leu Asp Val Gln Lys Glu Ala 
    370                 375                 380


Ile Asn Leu Leu Lys Asn Tyr Gln Thr Leu Asn Glu Ala Ile Met His 
385                 390                 395                 400


Gln Tyr Pro Asn Phe Lys Glu Glu Ala Gln Trp Val Arg Lys Tyr Phe 
                405                 410                 415


Arg Glu Glu Gln Lys Arg Met Asn Leu Ser Pro Ala Lys Gln Phe Asn 
            420                 425                 430


Ile Tyr Lys Lys Asp Phe Gly Lys Met Thr Ala Asn Ser Val Ser Val 
        435                 440                 445


Ala Thr Cys Glu Gln Leu Thr Tyr Tyr Ser Lys Ser Val Gly Phe Met 
    450                 455                 460


Gln Trp Asp Asn Asn Gly Asn Thr Gly Asn Ala Thr Cys Phe Val Phe 
465                 470                 475                 480


Asn Gly Gly Tyr Ile Phe Thr Cys Arg His Val Val His Leu Met Val 
                485                 490                 495


Gly Lys Asn Thr His Pro Ser Leu Trp Pro Asp Ile Ile Ser Lys Cys 
            500                 505                 510


Ala Lys Val Thr Phe Thr Tyr Thr Glu Phe Cys Pro Thr Pro Asp Asn 
        515                 520                 525


Trp Phe Ser Ile Glu Pro Trp Leu Lys Val Ser Asn Glu Asn Leu Asp 
    530                 535                 540


Tyr Ala Ile Leu Lys Leu Lys Glu Asn Gly Asn Ala Phe Pro Pro Gly 
545                 550                 555                 560


Leu Trp Arg Gln Ile Ser Pro Gln Pro Ser Thr Gly Leu Ile Tyr Leu 
                565                 570                 575


Ile Gly His Pro Glu Gly Gln Ile Lys Lys Ile Asp Gly Cys Thr Val 
            580                 585                 590


Ile Pro Leu Asn Glu Arg Leu Lys Lys Tyr Pro Asn Asp Cys Gln Asp 
        595                 600                 605


Gly Leu Val Asp Leu Tyr Asp Thr Thr Ser Asn Val Tyr Cys Met Phe 
    610                 615                 620


Thr Gln Arg Ser Phe Leu Ser Glu Val Trp Asn Thr His Thr Leu Ser 
625                 630                 635                 640


Tyr Asp Thr Cys Phe Ser Asp Gly Ser Ser Gly Ser Pro Val Phe Asn 
                645                 650                 655


Ala Ser Gly Lys Leu Val Ala Leu His Thr Phe Gly Leu Phe Tyr Gln 
            660                 665                 670


Arg Gly Phe Asn Val His Ala Leu Ile Glu Phe Gly Tyr Ser Met Asp 
        675                 680                 685


Ser Ile Leu Cys Asp Ile Lys Lys Thr Asn Glu Ser Leu Tyr Lys Ser 
    690                 695                 700


Leu Asn Asp Glu Lys Leu Glu Thr Tyr Asp Glu Glu Lys Gly Lys Gln 
705                 710                 715                 720


Glu Ser Ser Leu Gln Asp His Gln Ile Glu Pro Met Glu Cys 
                725                 730


<210>  877
<211>  1368
<212>  DNA
<213>  Homo sapiens

<400>  877
gtgactgcct cttccagggc gggcggtgtg gtgcacgcat tgctgtgctc caactccctc     60

agggcctgtg ttgccgcact ctgctgctat gagcttcctc aaaagtttcc cgccgcctgg    120

gccagcggag gggctcctgc ggcagcagcc agacactgag gctgtgctga acgggaaggg    180

cctcggcact ggtacccttt acatcgctga gagccgcctg tcttggttag atggctctgg    240

attaggattc tcactggaat accccaccat tagtttacat gcattatcca gggaccgaag    300

tgactgtcta ggagagcatt tgtatgttat ggtgaatgcc aaatttgaag aagaatcaaa    360

agaacctgtt gctgatgaag aagaggaaga cagtgatgat gatgttgaac ctattactga    420

atttagattt gtgcctagtg ataaatcagc gttggaggca atgttcactg caatgtgcga    480

atgccaggcc ttgcatccag atcctgagga tgaggattca gatgactacg atggagaaga    540

atatgatgtg gaagcacatg aacaaggaca gggggacatc cctacatttt acacctatga    600

agaaggatta tcccatctaa cagcagaagg ccaagccaca ctggagagat tagaaggaat    660

gctttctcag tctgtgagca gccagtataa tatggctggg gtcaggacag aagattcaat    720

aagagattat gaagatggga tggaggtgga taccacacca acagttgctg gacagtttga    780

ggatgcagat gttgatcact gaaaatgatt tatgcaagtt taagattctg ctcctaagtg    840

taggagagaa cttggtgcct cttccactct ggagtgaagt taatgaaagt ctttttcctt    900

ttccaaaacc caacctgaac cagttctttc ttgagacaga ctatactgag acaacaagtt    960

gtcaccagca gaagatagat aatatgacct ttattaactt gatgaattaa cttaaccaag   1020

agggtatttg tagtttacta tttaccctaa aactttctgt gtctgggtac cctctgagta   1080

ggcctataat tcctaccttg actgtgtgca tcatttgtaa gctagcagat ctatgtggtg   1140

aaaatgcaca ggagcttggt agactgcggg ggaaagagag agctcctttc gccatgtttt   1200

accagtctgc tgttataacc tcttaggttg tatcctttaa tttccagcct tttaggttag   1260

tttctgtaac agaacaagtg agtctgggat gaagtcctca aagtacttca aatggtaatt   1320

gttttgtttt tgtaatagct taacaaataa acctaggttt tctataaa                1368


<210>  878
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  878

Met Ser Phe Leu Lys Ser Phe Pro Pro Pro Gly Pro Ala Glu Gly Leu 
1               5                   10                  15


Leu Arg Gln Gln Pro Asp Thr Glu Ala Val Leu Asn Gly Lys Gly Leu 
            20                  25                  30


Gly Thr Gly Thr Leu Tyr Ile Ala Glu Ser Arg Leu Ser Trp Leu Asp 
        35                  40                  45


Gly Ser Gly Leu Gly Phe Ser Leu Glu Tyr Pro Thr Ile Ser Leu His 
    50                  55                  60


Ala Leu Ser Arg Asp Arg Ser Asp Cys Leu Gly Glu His Leu Tyr Val 
65                  70                  75                  80


Met Val Asn Ala Lys Phe Glu Glu Glu Ser Lys Glu Pro Val Ala Asp 
                85                  90                  95


Glu Glu Glu Glu Asp Ser Asp Asp Asp Val Glu Pro Ile Thr Glu Phe 
            100                 105                 110


Arg Phe Val Pro Ser Asp Lys Ser Ala Leu Glu Ala Met Phe Thr Ala 
        115                 120                 125


Met Cys Glu Cys Gln Ala Leu His Pro Asp Pro Glu Asp Glu Asp Ser 
    130                 135                 140


Asp Asp Tyr Asp Gly Glu Glu Tyr Asp Val Glu Ala His Glu Gln Gly 
145                 150                 155                 160


Gln Gly Asp Ile Pro Thr Phe Tyr Thr Tyr Glu Glu Gly Leu Ser His 
                165                 170                 175


Leu Thr Ala Glu Gly Gln Ala Thr Leu Glu Arg Leu Glu Gly Met Leu 
            180                 185                 190


Ser Gln Ser Val Ser Ser Gln Tyr Asn Met Ala Gly Val Arg Thr Glu 
        195                 200                 205


Asp Ser Ile Arg Asp Tyr Glu Asp Gly Met Glu Val Asp Thr Thr Pro 
    210                 215                 220


Thr Val Ala Gly Gln Phe Glu Asp Ala Asp Val Asp His 
225                 230                 235


<210>  879
<211>  5138
<212>  DNA
<213>  Homo sapiens

<400>  879
gatccgcaga ggagcccact tgagagcgcc tcctgtcgtc tgtaaggttg ccttgccatc     60

cctcggcacc ccaacttccc ccgccccccc atcgcctcct cctccatcct ccagttcaaa    120

atggcgacgg cggcggcagc ggcggcggtg atggctcctc cgggctgccc gggttcgtgc    180

cccaacttcg ccgtagtctg ctccttcttg gagcgctacg ggccgctgct agacctgcct    240

gagttgccgt tccctgagct ggagcgggtg ctgcaggcgc cgccgccgga cgtcggcaac    300

ggagaagtac caaaagaatt ggtggagctc catttgaagc tgatgaggaa aattggcaaa    360

tctgttactg cagacagatg ggaaaaatat ttgatcaaga tatgccaaga gtttaacagt    420

acctgggcat gggagatgga gaagaagggc tatcttgaaa tgagtgttga atgcaaacta    480

gcactcttaa agtacctctg tgagtgtcag tttgatgaca atctcaaatt caagaatatt    540

attaatgagg aggatgccga tactatgcgt ctccagccaa ttggtcgaga caaagatggc    600

ctcatgtact ggtaccaatt ggatcaagat cacaatgtca gaatgtacat agaagaacaa    660

gatgatcaag atggctcttc atggaaatgc attgtcagaa atcgaaacga gttggctgag    720

actcttgcac tcctgaaagc acaaattgat cctgtactat tgaaaaactc tagccaacaa    780

gacaactctt ctcgggaaag tcccagctta gaggatgagg agactaaaaa agaggaagaa    840

acacctaaac aagaggaaca gaaagaaagt gaaaagatga aaagtgagga gcagcctatg    900

gatttagaaa accgttctac agccaatgtt ctagaagaga ctactgtgaa aaaagaaaaa    960

gaagatgaaa aggaacttgt gaaactgcca gtcatagtga agctagaaaa acctttgcca   1020

gaaaatgaag aaaaaaagat tatcaaagaa gaaagtgatt ccttcaagga aaatgtcaaa   1080

cccattaaag ttgaggtgaa ggaatgtaga gcagatccta aagataccaa aagtagcatg   1140

gagaagccag tggcacagga gcctgaaagg atcgaatttg gtggcaatat taaatcttct   1200

cacgaaatta ctgagaaatc tactgaagaa actgagaaac ttaaaaatga ccagcaggcc   1260

aagataccac taaaaaaacg agaaattaaa ctgagtgatg attttgacag tccagtcaag   1320

ggacctttgt gtaaatcagt tactccaaca aaagagtttt tgaaagatga aataaaacaa   1380

gaggaagaga cttgtaaaag gatctctaca atcactgctt tgggtcatga agggaaacag   1440

ctggtaaatg gagaagttag tgatgaaagg gtagctccaa attttaagac agaaccaata   1500

gagacaaagt tttatgagac aaaggaagag agctatagcc cctctaagga cagaaatatc   1560

atcacggagg gaaatggaac agagtcctta aattctgtca taacaagtat gaaaacaggt   1620

gagcttgaga aagaaacagc ccctttgagg aaagatgcag atagttcaat atcagtctta   1680

gagatccata gtcaaaaagc acaaatagag gaacccgatc ctccagaaat ggaaacttct   1740

cttgattctt ctgagatggc aaaagatctc tcttcaaaaa ctgctttatc ttccaccgag   1800

tcgtgtacca tgaaaggtga agagaagtct cccaaaacta agaaggataa gcgcccacca   1860

atcctagaat gtcttgaaaa gttagagaag tccaaaaaga cttttcttga taaggacgca   1920

caaagattga gtccaatacc agaagaagtt ccaaagagta ctctagagtc agaaaagcct   1980

ggctctcctg aggcagctga aacttctcca ccatctaata tcattgacca ctgtgagaaa   2040

ctagcctcag aaaaagaagt ggtagaatgc cagagtacaa gtactgttgg tggccagtct   2100

gtgaaaaaag tagacctaga aaccctaaaa gaggattctg agttcacaaa ggtagaaatg   2160

gataatctgg acaatgccca gacctctggc atagaggagc cttctgagac aaagggttct   2220

atgcaaaaaa gcaaattcaa atataagttg gttcctgaag aagaaaccac tgcctcagaa   2280

aatacagaga taacctctga aaggcagaaa gagggcatca aattaacaat caggatatca   2340

agtcggaaaa agaagcccga ttctcccccc aaagttctag aaccagaaaa caagcaagag   2400

aagacagaaa aggaagagga gaaaacaaat gtgggtcgta ctttaagaag atctccaaga   2460

atatctagac ccactgcaaa agtggctgag atcagagatc agaaagctga taaaaaaaga   2520

ggggaaggag aagatgaggt ggaagaagag tcaacagctt tgcaaaaaac tgacaaaaag   2580

gaaattttga aaaaatcaga gaaagataca aattctaaag taagcaaggt aaaacccaaa   2640

ggcaaagttc gatggactgg ttctcggaca cgtggcagat ggaaatattc cagcaatgat   2700

gaaagtgaag ggtctggcag tgaaaaatca tctgcagctt cagaagagga ggaagaaaag   2760

gaaagtgaag aagccatcct agcagatgat gatgaaccat gcaaaaaatg tggccttcca   2820

aaccatcctg agctaattct tctgtgtgac tcttgcgata gtggatacca tactgcctgc   2880

cttcgccctc ctctgatgat catcccagat ggagaatggt tctgcccacc ttgccaacat   2940

aaactgctct gtgaaaaatt agaggaacag ttgcaggatt tggatgttgc cttaaagaag   3000

aaagagcgtg ccgaacgaag aaaagaacgc ttggtgtatg ttggtatcag tattgaaaac   3060

atcattcctc cacaagagcc agacttttct gaagatcaag aagaaaagaa aaaagattca   3120

aaaaaatcca aagcaaactt gcttgaaagg aggtcaacaa gaacaaggaa atgtataagc   3180

tacagatttg atgagtttga tgaagcaatt gatgaagcta ttgaagatga catcaaagaa   3240

gccgatggag gaggagttgg ccgaggaaaa gatatctcca ccatcacagg tcatcgtggg   3300

aaagacatct ctactatttt ggatgaagaa agaaaagaaa ataaacgacc ccagagggca   3360

gctgctgctc gaaggaagaa acgccggcga ttaaatgatc tggacagtga tagcaacctg   3420

gatgaagaag agagcgagga tgaattcaag atcagtgatg gatctcaaga tgagtttgtt   3480

gtgtctgatg aaaacccaga tgaaagtgaa gaagatccgc catctaatga tgacagtgac   3540

actgactttt gtagccgtag actgaggcga cacccctctc ggccaatgag gcagagcagg   3600

cgtttgcgaa gaaagacccc aaagaaaaaa tattccgatg atgatgaaga ggaggaatct   3660

gaggagaata gtagagactc tgaaagtgac ttcagtgatg attttagtga tgattttgta   3720

gaaactcggc gaaggcggtc aaggagaaat cagaaaagac aaattaacta caaagaagac   3780

tcagaaagtg acggttccca gaagagtttg cgacgtggta aagaaataag gcgagtacac   3840

aagcgaagac tttccagctc agagagtgaa gagagctatt tgtccaagaa ctctgaagat   3900

gatgagctag ctaaagaatc aaagcggtca gttcgaaagc ggggccgaag cacagacgag   3960

tattcagaag cagatgagga ggaggaggaa gaggaaggca aaccatcccg caaacggcta   4020

caccggattg agacggatga ggaggagagt tgtgacaatg ctcatggaga tgcaaatcag   4080

cctgcccgtg acagccagcc tagggtcctg ccctcagaac aagagagcac caagaagccc   4140

taccggatag aaagtgatga ggaagaggac tttgaaaatg taggcaaagt ggggagccca   4200

ttggactata gcttagtgga cttaccttca accaatggac agagccctgg caaagccatt   4260

gagaacttga ttggcaagcc tactgagaag tctcagaccc ccaaggacaa cagcacagcc   4320

agtgcaagcc tagcctccaa tgggacaagt ggtgggcagg aggcaggagc accagaagag   4380

gaggaagatg agcttttgag agtgactgac cttgttgatt atgtctgtaa cagtgaacag   4440

ttataagact ttttttccat ttttgtgcta atttattcca cggtagctct cacaccagcg   4500

ggccagttat taaaagctgt ttaatttttc ctagaaaact ccactacaga atgactttta   4560

gaagaaaaat ttcaacaaat cctgaagtct ttctgtgaag tgaccagttc tgaactttga   4620

agataaataa ttgctgtaaa ttccttttga ttttcttttt ccaggttcat ggtccttggt   4680

aatttcattc atggaaaaaa atcttattat aataacaaca aagatttgta tatttttgac   4740

tttatatttc ctgagctctc ctgactttgt gaaaaagggt ggatgaaaat gcattccgaa   4800

tctgtgaggg cccaaaacag aatttagggg tgggtgaaag cacttgtgct ttagcttttt   4860

catattaaat atatattata tttaaacatt catggcatag atgatgattt acagacaatt   4920

taaaagttca agtctgtact gttacagttt gagaattgta gataacatca tacataagtc   4980

atttagtaac agcctttgtg aaatgaactt gtttactatt ggagataacc acacttaata   5040

aagaagagac agtgaaagta ccatcataat taacctaaat ttttgttata gcagagtttc   5100

ttgtttaaaa aaaaataaaa tcatctgaaa agcaaaaa                           5138


<210>  880
<211>  1441
<212>  PRT
<213>  Homo sapiens

<400>  880

Met Ala Thr Ala Ala Ala Ala Ala Ala Val Met Ala Pro Pro Gly Cys 
1               5                   10                  15


Pro Gly Ser Cys Pro Asn Phe Ala Val Val Cys Ser Phe Leu Glu Arg 
            20                  25                  30


Tyr Gly Pro Leu Leu Asp Leu Pro Glu Leu Pro Phe Pro Glu Leu Glu 
        35                  40                  45


Arg Val Leu Gln Ala Pro Pro Pro Asp Val Gly Asn Gly Glu Val Pro 
    50                  55                  60


Lys Glu Leu Val Glu Leu His Leu Lys Leu Met Arg Lys Ile Gly Lys 
65                  70                  75                  80


Ser Val Thr Ala Asp Arg Trp Glu Lys Tyr Leu Ile Lys Ile Cys Gln 
                85                  90                  95


Glu Phe Asn Ser Thr Trp Ala Trp Glu Met Glu Lys Lys Gly Tyr Leu 
            100                 105                 110


Glu Met Ser Val Glu Cys Lys Leu Ala Leu Leu Lys Tyr Leu Cys Glu 
        115                 120                 125


Cys Gln Phe Asp Asp Asn Leu Lys Phe Lys Asn Ile Ile Asn Glu Glu 
    130                 135                 140


Asp Ala Asp Thr Met Arg Leu Gln Pro Ile Gly Arg Asp Lys Asp Gly 
145                 150                 155                 160


Leu Met Tyr Trp Tyr Gln Leu Asp Gln Asp His Asn Val Arg Met Tyr 
                165                 170                 175


Ile Glu Glu Gln Asp Asp Gln Asp Gly Ser Ser Trp Lys Cys Ile Val 
            180                 185                 190


Arg Asn Arg Asn Glu Leu Ala Glu Thr Leu Ala Leu Leu Lys Ala Gln 
        195                 200                 205


Ile Asp Pro Val Leu Leu Lys Asn Ser Ser Gln Gln Asp Asn Ser Ser 
    210                 215                 220


Arg Glu Ser Pro Ser Leu Glu Asp Glu Glu Thr Lys Lys Glu Glu Glu 
225                 230                 235                 240


Thr Pro Lys Gln Glu Glu Gln Lys Glu Ser Glu Lys Met Lys Ser Glu 
                245                 250                 255


Glu Gln Pro Met Asp Leu Glu Asn Arg Ser Thr Ala Asn Val Leu Glu 
            260                 265                 270


Glu Thr Thr Val Lys Lys Glu Lys Glu Asp Glu Lys Glu Leu Val Lys 
        275                 280                 285


Leu Pro Val Ile Val Lys Leu Glu Lys Pro Leu Pro Glu Asn Glu Glu 
    290                 295                 300


Lys Lys Ile Ile Lys Glu Glu Ser Asp Ser Phe Lys Glu Asn Val Lys 
305                 310                 315                 320


Pro Ile Lys Val Glu Val Lys Glu Cys Arg Ala Asp Pro Lys Asp Thr 
                325                 330                 335


Lys Ser Ser Met Glu Lys Pro Val Ala Gln Glu Pro Glu Arg Ile Glu 
            340                 345                 350


Phe Gly Gly Asn Ile Lys Ser Ser His Glu Ile Thr Glu Lys Ser Thr 
        355                 360                 365


Glu Glu Thr Glu Lys Leu Lys Asn Asp Gln Gln Ala Lys Ile Pro Leu 
    370                 375                 380


Lys Lys Arg Glu Ile Lys Leu Ser Asp Asp Phe Asp Ser Pro Val Lys 
385                 390                 395                 400


Gly Pro Leu Cys Lys Ser Val Thr Pro Thr Lys Glu Phe Leu Lys Asp 
                405                 410                 415


Glu Ile Lys Gln Glu Glu Glu Thr Cys Lys Arg Ile Ser Thr Ile Thr 
            420                 425                 430


Ala Leu Gly His Glu Gly Lys Gln Leu Val Asn Gly Glu Val Ser Asp 
        435                 440                 445


Glu Arg Val Ala Pro Asn Phe Lys Thr Glu Pro Ile Glu Thr Lys Phe 
    450                 455                 460


Tyr Glu Thr Lys Glu Glu Ser Tyr Ser Pro Ser Lys Asp Arg Asn Ile 
465                 470                 475                 480


Ile Thr Glu Gly Asn Gly Thr Glu Ser Leu Asn Ser Val Ile Thr Ser 
                485                 490                 495


Met Lys Thr Gly Glu Leu Glu Lys Glu Thr Ala Pro Leu Arg Lys Asp 
            500                 505                 510


Ala Asp Ser Ser Ile Ser Val Leu Glu Ile His Ser Gln Lys Ala Gln 
        515                 520                 525


Ile Glu Glu Pro Asp Pro Pro Glu Met Glu Thr Ser Leu Asp Ser Ser 
    530                 535                 540


Glu Met Ala Lys Asp Leu Ser Ser Lys Thr Ala Leu Ser Ser Thr Glu 
545                 550                 555                 560


Ser Cys Thr Met Lys Gly Glu Glu Lys Ser Pro Lys Thr Lys Lys Asp 
                565                 570                 575


Lys Arg Pro Pro Ile Leu Glu Cys Leu Glu Lys Leu Glu Lys Ser Lys 
            580                 585                 590


Lys Thr Phe Leu Asp Lys Asp Ala Gln Arg Leu Ser Pro Ile Pro Glu 
        595                 600                 605


Glu Val Pro Lys Ser Thr Leu Glu Ser Glu Lys Pro Gly Ser Pro Glu 
    610                 615                 620


Ala Ala Glu Thr Ser Pro Pro Ser Asn Ile Ile Asp His Cys Glu Lys 
625                 630                 635                 640


Leu Ala Ser Glu Lys Glu Val Val Glu Cys Gln Ser Thr Ser Thr Val 
                645                 650                 655


Gly Gly Gln Ser Val Lys Lys Val Asp Leu Glu Thr Leu Lys Glu Asp 
            660                 665                 670


Ser Glu Phe Thr Lys Val Glu Met Asp Asn Leu Asp Asn Ala Gln Thr 
        675                 680                 685


Ser Gly Ile Glu Glu Pro Ser Glu Thr Lys Gly Ser Met Gln Lys Ser 
    690                 695                 700


Lys Phe Lys Tyr Lys Leu Val Pro Glu Glu Glu Thr Thr Ala Ser Glu 
705                 710                 715                 720


Asn Thr Glu Ile Thr Ser Glu Arg Gln Lys Glu Gly Ile Lys Leu Thr 
                725                 730                 735


Ile Arg Ile Ser Ser Arg Lys Lys Lys Pro Asp Ser Pro Pro Lys Val 
            740                 745                 750


Leu Glu Pro Glu Asn Lys Gln Glu Lys Thr Glu Lys Glu Glu Glu Lys 
        755                 760                 765


Thr Asn Val Gly Arg Thr Leu Arg Arg Ser Pro Arg Ile Ser Arg Pro 
    770                 775                 780


Thr Ala Lys Val Ala Glu Ile Arg Asp Gln Lys Ala Asp Lys Lys Arg 
785                 790                 795                 800


Gly Glu Gly Glu Asp Glu Val Glu Glu Glu Ser Thr Ala Leu Gln Lys 
                805                 810                 815


Thr Asp Lys Lys Glu Ile Leu Lys Lys Ser Glu Lys Asp Thr Asn Ser 
            820                 825                 830


Lys Val Ser Lys Val Lys Pro Lys Gly Lys Val Arg Trp Thr Gly Ser 
        835                 840                 845


Arg Thr Arg Gly Arg Trp Lys Tyr Ser Ser Asn Asp Glu Ser Glu Gly 
    850                 855                 860


Ser Gly Ser Glu Lys Ser Ser Ala Ala Ser Glu Glu Glu Glu Glu Lys 
865                 870                 875                 880


Glu Ser Glu Glu Ala Ile Leu Ala Asp Asp Asp Glu Pro Cys Lys Lys 
                885                 890                 895


Cys Gly Leu Pro Asn His Pro Glu Leu Ile Leu Leu Cys Asp Ser Cys 
            900                 905                 910


Asp Ser Gly Tyr His Thr Ala Cys Leu Arg Pro Pro Leu Met Ile Ile 
        915                 920                 925


Pro Asp Gly Glu Trp Phe Cys Pro Pro Cys Gln His Lys Leu Leu Cys 
    930                 935                 940


Glu Lys Leu Glu Glu Gln Leu Gln Asp Leu Asp Val Ala Leu Lys Lys 
945                 950                 955                 960


Lys Glu Arg Ala Glu Arg Arg Lys Glu Arg Leu Val Tyr Val Gly Ile 
                965                 970                 975


Ser Ile Glu Asn Ile Ile Pro Pro Gln Glu Pro Asp Phe Ser Glu Asp 
            980                 985                 990


Gln Glu Glu Lys Lys Lys Asp Ser Lys Lys Ser Lys Ala Asn Leu Leu 
        995                 1000                1005


Glu Arg Arg Ser Thr Arg Thr Arg Lys Cys Ile Ser Tyr Arg Phe Asp 
    1010                1015                1020


Glu Phe Asp Glu Ala Ile Asp Glu Ala Ile Glu Asp Asp Ile Lys Glu 
1025                1030                1035                1040


Ala Asp Gly Gly Gly Val Gly Arg Gly Lys Asp Ile Ser Thr Ile Thr 
                1045                1050                1055


Gly His Arg Gly Lys Asp Ile Ser Thr Ile Leu Asp Glu Glu Arg Lys 
            1060                1065                1070


Glu Asn Lys Arg Pro Gln Arg Ala Ala Ala Ala Arg Arg Lys Lys Arg 
        1075                1080                1085


Arg Arg Leu Asn Asp Leu Asp Ser Asp Ser Asn Leu Asp Glu Glu Glu 
    1090                1095                1100


Ser Glu Asp Glu Phe Lys Ile Ser Asp Gly Ser Gln Asp Glu Phe Val 
1105                1110                1115                1120


Val Ser Asp Glu Asn Pro Asp Glu Ser Glu Glu Asp Pro Pro Ser Asn 
                1125                1130                1135


Asp Asp Ser Asp Thr Asp Phe Cys Ser Arg Arg Leu Arg Arg His Pro 
            1140                1145                1150


Ser Arg Pro Met Arg Gln Ser Arg Arg Leu Arg Arg Lys Thr Pro Lys 
        1155                1160                1165


Lys Lys Tyr Ser Asp Asp Asp Glu Glu Glu Glu Ser Glu Glu Asn Ser 
    1170                1175                1180


Arg Asp Ser Glu Ser Asp Phe Ser Asp Asp Phe Ser Asp Asp Phe Val 
1185                1190                1195                1200


Glu Thr Arg Arg Arg Arg Ser Arg Arg Asn Gln Lys Arg Gln Ile Asn 
                1205                1210                1215


Tyr Lys Glu Asp Ser Glu Ser Asp Gly Ser Gln Lys Ser Leu Arg Arg 
            1220                1225                1230


Gly Lys Glu Ile Arg Arg Val His Lys Arg Arg Leu Ser Ser Ser Glu 
        1235                1240                1245


Ser Glu Glu Ser Tyr Leu Ser Lys Asn Ser Glu Asp Asp Glu Leu Ala 
    1250                1255                1260


Lys Glu Ser Lys Arg Ser Val Arg Lys Arg Gly Arg Ser Thr Asp Glu 
1265                1270                1275                1280


Tyr Ser Glu Ala Asp Glu Glu Glu Glu Glu Glu Glu Gly Lys Pro Ser 
                1285                1290                1295


Arg Lys Arg Leu His Arg Ile Glu Thr Asp Glu Glu Glu Ser Cys Asp 
            1300                1305                1310


Asn Ala His Gly Asp Ala Asn Gln Pro Ala Arg Asp Ser Gln Pro Arg 
        1315                1320                1325


Val Leu Pro Ser Glu Gln Glu Ser Thr Lys Lys Pro Tyr Arg Ile Glu 
    1330                1335                1340


Ser Asp Glu Glu Glu Asp Phe Glu Asn Val Gly Lys Val Gly Ser Pro 
1345                1350                1355                1360


Leu Asp Tyr Ser Leu Val Asp Leu Pro Ser Thr Asn Gly Gln Ser Pro 
                1365                1370                1375


Gly Lys Ala Ile Glu Asn Leu Ile Gly Lys Pro Thr Glu Lys Ser Gln 
            1380                1385                1390


Thr Pro Lys Asp Asn Ser Thr Ala Ser Ala Ser Leu Ala Ser Asn Gly 
        1395                1400                1405


Thr Ser Gly Gly Gln Glu Ala Gly Ala Pro Glu Glu Glu Glu Asp Glu 
    1410                1415                1420


Leu Leu Arg Val Thr Asp Leu Val Asp Tyr Val Cys Asn Ser Glu Gln 
1425                1430                1435                1440


Leu 



<210>  881
<211>  939
<212>  DNA
<213>  Homo sapiens

<400>  881
atagagacgt tctttgccga gagtcgtcgg ggtttcctgc ttcaacagtg cttggacgga     60

acccggtgct cgtcccccac cccagccggc cgcccatagc cagccctccc tcacctcttc    120

acggcaccct cagaccgccc caaggcccct gccgccgccc cagcgccacg cagccactgc    180

caccgccgcc acctctcctt agtcgccgcc atgaggacca cgtccacctc acaggtgcgc    240

cagaactacc accaggactc agaggccgcc atcaaccgcc agatcaacct agagctctgt    300

gcctcctacg tttacctgtc catgtcttac tgctttgacc gtgatgatgt ggctttgaag    360

aactttgcca aatactttct tcaccaatct catgaggaga gggagcatgc tgagaaactg    420

atgaagctgc agaaccaacg aggtggccga atcttccttc aggatatcaa aaaaccagac    480

tgtgatgact gggagagcgg gctgaatgtg atggagtgtg cattacattt ggaaaaaaat    540

gtgaatcagt cactactgga actgcacaaa ttggccactg acaaaaatga cccccatttg    600

tgtgacttca ttgagacaca ttacctgaat gagcaggtga aagccatcaa agaattggat    660

gaccatgtga ccaacttgca caagatggga gcactcgaat ctggcttggc agaatatctc    720

tttgacaagc acaccctggg agacagtgat aatgaaagct aagcctcggc taatttcccc    780

gtagccgtgg ggtgacttcc ctggtcacca aggcagtgca tgcatgttgg ggtttccttt    840

accttttcta taagttgtac caaaacatcc acctaagttc tttgatttgt gccattcctt    900

cagatgaaga aatttggtac ccccccccaa aaaaagtaa                           939


<210>  882
<211>  524
<212>  DNA
<213>  Homo sapiens

<400>  882
atggctttga aggttaccgg aaaaacacgc gtggagctgg aggtggcagt tcaccgaaat     60

tgaatcactc taacgagccg caacataaaa tccctggaaa aggtgtgtgc tgacttcatc    120

agaggagcag aggcaaagaa tctccaagtg aaaggaccag ttcgaatacc taccaagact    180

ttgagaatca ctacagaaaa agtccttgtg gtgaaggttc taagacgtgg gatcctttcc    240

agatgagaat ccacaagcga ctcattgact tgcacagtcc ttctgagatt gttaagcaga    300

ttgcttccat cagtttgagc cgggagttga ggtgaaagtc accattgcag atgcttaagt    360

caactatttt aataaattga ttaccagttg ttaaaaaaaa attataaatg gcagacttga    420

tcccattcat cattagacta ctttcatgtt ttgctcagaa ttaagtaagt tttaatattc    480

atttaaaaat acttatcaaa taaatttggt ttctctcaaa gtaa                     524


<210>  883
<211>  557
<212>  DNA
<213>  Homo sapiens

<400>  883
ccgaagcagc gctgggagcg taagtgcggg cagagcactg cgccgtttgg gaacgcaact     60

ttgaggagac agtgcggtgg acttcagtga agttccttat gacttcccct gaaattgctt    120

ccttatcatg ggggcaaatg aaagtaaaag gctctaatac aacctataag gactgcaaag    180

tatggccagg gggtagtcgg acttgggatt ggagagaaac aggaactgag cattctcctg    240

gtgtgcagcc tgcagatgtg aaggaagttg ttgagaaggg tgtacagact cttgtgattg    300

gccgagggat gagtgaggcc ttgaaggtgc cttcatcaac tgtggagtac ctcaagaaac    360

atggcattga tgtgcgggtc ctccagacag agcaggcagt gaaggagtat aatgccttgg    420

ttgcccaagg ggtcagggtg ggaggtgtct tccattccac ctgctgatgg agccttaaga    480

ggagaataaa tcactaagtg cctaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    540

aaaaaaaaaa aaaaaaa                                                   557


<210>  884
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  884

Met Thr Ser Pro Glu Ile Ala Ser Leu Ser Trp Gly Gln Met Lys Val 
1               5                   10                  15


Lys Gly Ser Asn Thr Thr Tyr Lys Asp Cys Lys Val Trp Pro Gly Gly 
            20                  25                  30


Ser Arg Thr Trp Asp Trp Arg Glu Thr Gly Thr Glu His Ser Pro Gly 
        35                  40                  45


Val Gln Pro Ala Asp Val Lys Glu Val Val Glu Lys Gly Val Gln Thr 
    50                  55                  60


Leu Val Ile Gly Arg Gly Met Ser Glu Ala Leu Lys Val Pro Ser Ser 
65                  70                  75                  80


Thr Val Glu Tyr Leu Lys Lys His Gly Ile Asp Val Arg Val Leu Gln 
                85                  90                  95


Thr Glu Gln Ala Val Lys Glu Tyr Asn Ala Leu Val Ala Gln Gly Val 
            100                 105                 110


Arg Val Gly Gly Val Phe His Ser Thr Cys 
        115                 120


<210>  885
<211>  2929
<212>  DNA
<213>  Homo sapiens

<400>  885
gtttgcagcc tccgtgccag ggccgggggt gcggttcggg acgcgggatc ctaggtcggg     60

tcctgccccg cccatgtggc gccggcgtct gtgttgtctg cggtctccag ggcagcgccg    120

gggcgggcgg gggcccgggc ggcggcggcg gcggcgcggg aggatgcggg gcccgtccgg    180

gtcgcggccg cggaggagcg ccgggcaggt aacgcttttg tgaaccacaa ctttaaatat    240

cagccagctg ctcctatcaa cacgagtatc ccctgttaat tttttgcatt tttcaagatg    300

agtaaacgta aactaattcc caagctctct attcaatctc ctgtccttca taccaactta    360

aatgtccagt ccacacaccc acctttgaag aaagaagact tacatcggat ttcaaaagac    420

tccttggaat ctgattcaga aagcctcacg caagagatta tgtgccattc tgagtttgat    480

gatcgaatcc ggggcaacgg tatggagccc gacagcttag acgaggagga aagccctcga    540

tggggaagcc tgcacgagat ggaagaggaa gcaagtggaa aagcagctca gatggctcgc    600

gagcaaaacc accatacctg ggaccagggc gccaataaca ggcaacaacc aatagaagac    660

aaatattcag acctccgcta tgacccgaac tggaagagta agaaggagga agggcagctg    720

ctgtctgtgg aagcgttgcc ggagtccacg gacagctctt tagaaaatct gcctttggct    780

cccctctacc cttcccagga gacgtcaatg gaactctccg ggggaaaagg cgagcagaaa    840

gagagtccac agagtgcagc ttctttactt ggtagtgaat ttttaagccc aaactatgag    900

catggtgccc gtcgcagcaa gccgttttca gagctgagcg acagtgacct ggaggagaag    960

tcgagcagcc tttctccgta cgtgaagagc tcaagttcac ataacgaggt tttcctgccg   1020

ggatcacgtg gccctcggcg aaggaaatcc aaacaacatt ttgtggaaaa aaacaagctc   1080

actttgggat tacccacccc gaaaacggac tcttatcttc aacttcacaa taaaaaaaga   1140

ggggaatctc atccagaaca gatctcctac cccgtcagag taacagacaa gacgtctatt   1200

cagaatgcca aggaaatgga aaatgctgcc atcgatcctg aagataaatg gcatcaaaga   1260

gcacaacagc taaagaatta ccaggaacac tggtctcaat atgaaagtac aaaatcaagc   1320

aatgtaccaa gagggcaacc ttctgacatg gtgaatgacc atcaaccttc cagaagacca   1380

gccaagctca agattcgaaa gcagtgtaaa caccagaatg gcctgaagtc ttccacaacg   1440

gaagaggtga ctgccagtca ggggaaccag aataaccctc ccaggcagca acaaaaccaa   1500

aataagcctc ttgatacttc aacaaagcct gaatcgattg tgattatgca tgcctctaac   1560

aatgatgtac aagcctcaag ggcacttaga agccacaatc tcaaagaaac ctccaataca   1620

tttgctccac caaaacaggc ttttgacaag gtcttatcta aaaactctac tggatgtgac   1680

tctgggctga atgttaataa agaaagagga cacaaagacc aagaagagaa aagattttca   1740

tatcagcagc tacacaccct ttctgacatg gatttgaaca accttaatga actttctaag   1800

agacacgtgc tcctgagcca gaaaggctct cagtttgttt atcacataaa tactcatgga   1860

tcaaccaaaa ataagaaaca actcaaacag ccttatacag agacaaaata caggaactta   1920

gaaatgttat ggaaattcca ttcttcttct gacagccaga cggttagagc ttctccagat   1980

tcatggctca cccagataat ggagcagcat cagcaagcct tggtgcagct gaccgacgtg   2040

cagcccagtg aaggggcctt atccagcgtc acgcttccac ctatactgtc aagggtagaa   2100

agtgaatccc aactcagttc agagagaagc caaagaaacc aagtgaaaat tagccgtagc   2160

aattctgaag gctatctgtt tcaactggaa aagggaaaaa agcataagaa aagaagcagc   2220

agtaagaaca ccaagctgaa aggttatcag aaaagagacg tgaagcttgg aggcctcgga   2280

cctgactttg agtccatcag agacaaaacg caaaaattaa tacagcaaaa ggaatatgca   2340

aaacaagtca aggagtacaa catgaagaca ctatccattc tatcaaaacc acaaacagaa   2400

aaaactcaaa agaaatctgc tatccctcgg cagaaggctt tggaatacgc taagaccatc   2460

cccaaaccca aaccatcaaa tctgactcat caagcatcaa aggaacaaaa aaatccaacc   2520

tatgctggga aagaagaaag tttacctgaa atctcactgc tggaaatact gcagaacaga   2580

cacgaaaggg aaaaacaggc tgtggctgct ttcaaagtcc ttcacatcgt atagacaaca   2640

tttgatagga aggagaccaa aaatggtcca ggaatgaacg tggagaaaag aaacgccaac   2700

caccttctct gcgttgagag taatggccta ttattatcat ctatctgccg tccatgtttg   2760

ctttctgcag gatttaaaat atgaggccca attggattat ggtgccatat tttactttct   2820

aggaagaaaa ttttttaaat tatttatttt caaatcagtt agaattggag ctgaataata   2880

actagagaat aaagcttttg ttttatattg aaaaaaaaaa aaaaaaaaa               2929


<210>  886
<211>  778
<212>  PRT
<213>  Homo sapiens

<400>  886

Met Ser Lys Arg Lys Leu Ile Pro Lys Leu Ser Ile Gln Ser Pro Val 
1               5                   10                  15


Leu His Thr Asn Leu Asn Val Gln Ser Thr His Pro Pro Leu Lys Lys 
            20                  25                  30


Glu Asp Leu His Arg Ile Ser Lys Asp Ser Leu Glu Ser Asp Ser Glu 
        35                  40                  45


Ser Leu Thr Gln Glu Ile Met Cys His Ser Glu Phe Asp Asp Arg Ile 
    50                  55                  60


Arg Gly Asn Gly Met Glu Pro Asp Ser Leu Asp Glu Glu Glu Ser Pro 
65                  70                  75                  80


Arg Trp Gly Ser Leu His Glu Met Glu Glu Glu Ala Ser Gly Lys Ala 
                85                  90                  95


Ala Gln Met Ala Arg Glu Gln Asn His His Thr Trp Asp Gln Gly Ala 
            100                 105                 110


Asn Asn Arg Gln Gln Pro Ile Glu Asp Lys Tyr Ser Asp Leu Arg Tyr 
        115                 120                 125


Asp Pro Asn Trp Lys Ser Lys Lys Glu Glu Gly Gln Leu Leu Ser Val 
    130                 135                 140


Glu Ala Leu Pro Glu Ser Thr Asp Ser Ser Leu Glu Asn Leu Pro Leu 
145                 150                 155                 160


Ala Pro Leu Tyr Pro Ser Gln Glu Thr Ser Met Glu Leu Ser Gly Gly 
                165                 170                 175


Lys Gly Glu Gln Lys Glu Ser Pro Gln Ser Ala Ala Ser Leu Leu Gly 
            180                 185                 190


Ser Glu Phe Leu Ser Pro Asn Tyr Glu His Gly Ala Arg Arg Ser Lys 
        195                 200                 205


Pro Phe Ser Glu Leu Ser Asp Ser Asp Leu Glu Glu Lys Ser Ser Ser 
    210                 215                 220


Leu Ser Pro Tyr Val Lys Ser Ser Ser Ser His Asn Glu Val Phe Leu 
225                 230                 235                 240


Pro Gly Ser Arg Gly Pro Arg Arg Arg Lys Ser Lys Gln His Phe Val 
                245                 250                 255


Glu Lys Asn Lys Leu Thr Leu Gly Leu Pro Thr Pro Lys Thr Asp Ser 
            260                 265                 270


Tyr Leu Gln Leu His Asn Lys Lys Arg Gly Glu Ser His Pro Glu Gln 
        275                 280                 285


Ile Ser Tyr Pro Val Arg Val Thr Asp Lys Thr Ser Ile Gln Asn Ala 
    290                 295                 300


Lys Glu Met Glu Asn Ala Ala Ile Asp Pro Glu Asp Lys Trp His Gln 
305                 310                 315                 320


Arg Ala Gln Gln Leu Lys Asn Tyr Gln Glu His Trp Ser Gln Tyr Glu 
                325                 330                 335


Ser Thr Lys Ser Ser Asn Val Pro Arg Gly Gln Pro Ser Asp Met Val 
            340                 345                 350


Asn Asp His Gln Pro Ser Arg Arg Pro Ala Lys Leu Lys Ile Arg Lys 
        355                 360                 365


Gln Cys Lys His Gln Asn Gly Leu Lys Ser Ser Thr Thr Glu Glu Val 
    370                 375                 380


Thr Ala Ser Gln Gly Asn Gln Asn Asn Pro Pro Arg Gln Gln Gln Asn 
385                 390                 395                 400


Gln Asn Lys Pro Leu Asp Thr Ser Thr Lys Pro Glu Ser Ile Val Ile 
                405                 410                 415


Met His Ala Ser Asn Asn Asp Val Gln Ala Ser Arg Ala Leu Arg Ser 
            420                 425                 430


His Asn Leu Lys Glu Thr Ser Asn Thr Phe Ala Pro Pro Lys Gln Ala 
        435                 440                 445


Phe Asp Lys Val Leu Ser Lys Asn Ser Thr Gly Cys Asp Ser Gly Leu 
    450                 455                 460


Asn Val Asn Lys Glu Arg Gly His Lys Asp Gln Glu Glu Lys Arg Phe 
465                 470                 475                 480


Ser Tyr Gln Gln Leu His Thr Leu Ser Asp Met Asp Leu Asn Asn Leu 
                485                 490                 495


Asn Glu Leu Ser Lys Arg His Val Leu Leu Ser Gln Lys Gly Ser Gln 
            500                 505                 510


Phe Val Tyr His Ile Asn Thr His Gly Ser Thr Lys Asn Lys Lys Gln 
        515                 520                 525


Leu Lys Gln Pro Tyr Thr Glu Thr Lys Tyr Arg Asn Leu Glu Met Leu 
    530                 535                 540


Trp Lys Phe His Ser Ser Ser Asp Ser Gln Thr Val Arg Ala Ser Pro 
545                 550                 555                 560


Asp Ser Trp Leu Thr Gln Ile Met Glu Gln His Gln Gln Ala Leu Val 
                565                 570                 575


Gln Leu Thr Asp Val Gln Pro Ser Glu Gly Ala Leu Ser Ser Val Thr 
            580                 585                 590


Leu Pro Pro Ile Leu Ser Arg Val Glu Ser Glu Ser Gln Leu Ser Ser 
        595                 600                 605


Glu Arg Ser Gln Arg Asn Gln Val Lys Ile Ser Arg Ser Asn Ser Glu 
    610                 615                 620


Gly Tyr Leu Phe Gln Leu Glu Lys Gly Lys Lys His Lys Lys Arg Ser 
625                 630                 635                 640


Ser Ser Lys Asn Thr Lys Leu Lys Gly Tyr Gln Lys Arg Asp Val Lys 
                645                 650                 655


Leu Gly Gly Leu Gly Pro Asp Phe Glu Ser Ile Arg Asp Lys Thr Gln 
            660                 665                 670


Lys Leu Ile Gln Gln Lys Glu Tyr Ala Lys Gln Val Lys Glu Tyr Asn 
        675                 680                 685


Met Lys Thr Leu Ser Ile Leu Ser Lys Pro Gln Thr Glu Lys Thr Gln 
    690                 695                 700


Lys Lys Ser Ala Ile Pro Arg Gln Lys Ala Leu Glu Tyr Ala Lys Thr 
705                 710                 715                 720


Ile Pro Lys Pro Lys Pro Ser Asn Leu Thr His Gln Ala Ser Lys Glu 
                725                 730                 735


Gln Lys Asn Pro Thr Tyr Ala Gly Lys Glu Glu Ser Leu Pro Glu Ile 
            740                 745                 750


Ser Leu Leu Glu Ile Leu Gln Asn Arg His Glu Arg Glu Lys Gln Ala 
        755                 760                 765


Val Ala Ala Phe Lys Val Leu His Ile Val 
    770                 775


<210>  887
<211>  1865
<212>  DNA
<213>  Homo sapiens

<400>  887
gtttgcagcc tccgtgccag ggccgggggt gcggttcggg acgcgggatc ctaggtcggg     60

tcctgccccg cccatgtggc gccggcgtct gtgttgtctg cggtctccag ggcagcgccg    120

gggcgggcgg gggcccgggc ggcggcggcg gcggcgcggg aggatgcggg gcccgtccgg    180

gtcgcggccg cggaggagcg ccgggcaggt aacgcttttg tgaaccacaa ctttaaatat    240

cagccagctg ctcctatcaa cacgagtatc ccctgttaat tttttgcatt tttcaagatg    300

agtaaacgta aactaattcc caagctctct attcaatctc ctgtccttca taccaactta    360

aatgtccagt ccacacaccc acctttgaag aaagaagact tacatcggat ttcaaaagac    420

tccttggaat ctgattcaga aagcctcacg caagagatta tgtgccattc tgagtttgat    480

gatcgaatcc ggggcaacgg tatggagccc gacagcttag acgaggagga aagccctcga    540

tggggaagcc tgcacgagat ggaagaggaa gcaagtggaa aagcagctca gatggctcgc    600

gagcaaaacc accatacctg ggaccagggc gccaataaca ggcaacaacc aatagaagac    660

aaatattcag acctccgcta tgacccgaac tggaagagta agaaggagga agggcagctg    720

ctgtctgtgg aagcgttgcc ggagtccacg gacagctctt tagaaaatct gcctttggct    780

cccctctacc cttcccagga gacgtcaatg gaactctccg ggggaaaagg cgagcagaaa    840

gagagtccac agagtgcagc ttctttactt ggtagtgaat ttttaagccc aaactatgag    900

catggtgccc gtcgcagcaa gccgttttca gagctgagcg acagtgacct ggaggagaag    960

tcgagcagcc tttctccgta cgtgaagagc tcaagttcac ataacgaggt tttcctgccg   1020

ggatcacgtg gccctcggcg aaggaaatcc aaacaacatt ttgtggaaaa aaacaagctc   1080

actttgggat tacccacccc gaaaacggac tcttatcttc aacttcacaa taaaaaaaga   1140

ggggaatctc atccagaaca ggtcattttg agagtaaatt ctctcccacg tgatggattc   1200

aaaacctttt ggagccagta aacttagttc catttcacag gtgcacataa agaccttcct   1260

gcccacctcc tatggacatg tccagggata caggacaaga gtggggttag aatggtagag   1320

tccaccactc ttactggaaa gagcttgaga tttatcacct gctaatgtga ggtcattttc   1380

aaatacaaag gagaggttat tatgttaaat gtggttgccc ttagacctat tccaaatccc   1440

aactggtatt tttttttaac atattctaac ctgttctaac ctctaagcat tttctaatgg   1500

aacaaaatag atgaggtgga tgaacatttg tggcttttct tcagagactc ccttttttgt   1560

cttaaagaat tacgtctggt ggcacgttgg ctcatgcctg taatcccagc actttgggag   1620

gtcgaggtgg gaggatcact tgaggccacg agttcaagac cagcctggcc aacatggtga   1680

aacccatcta taccaaaaat acaaaaatta gccgggtgtg gtgatgcaca cctgtaatcc   1740

cagctactcg ggaggctgag gcacaagaat cgcttgaaca cgggaggcag aggttgcagt   1800

gagccgagat ggcgccacta cactccagcc tgggttatag agtgagactc tgtctcaaaa   1860

taaat                                                               1865


<210>  888
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  888

Met Ser Lys Arg Lys Leu Ile Pro Lys Leu Ser Ile Gln Ser Pro Val 
1               5                   10                  15


Leu His Thr Asn Leu Asn Val Gln Ser Thr His Pro Pro Leu Lys Lys 
            20                  25                  30


Glu Asp Leu His Arg Ile Ser Lys Asp Ser Leu Glu Ser Asp Ser Glu 
        35                  40                  45


Ser Leu Thr Gln Glu Ile Met Cys His Ser Glu Phe Asp Asp Arg Ile 
    50                  55                  60


Arg Gly Asn Gly Met Glu Pro Asp Ser Leu Asp Glu Glu Glu Ser Pro 
65                  70                  75                  80


Arg Trp Gly Ser Leu His Glu Met Glu Glu Glu Ala Ser Gly Lys Ala 
                85                  90                  95


Ala Gln Met Ala Arg Glu Gln Asn His His Thr Trp Asp Gln Gly Ala 
            100                 105                 110


Asn Asn Arg Gln Gln Pro Ile Glu Asp Lys Tyr Ser Asp Leu Arg Tyr 
        115                 120                 125


Asp Pro Asn Trp Lys Ser Lys Lys Glu Glu Gly Gln Leu Leu Ser Val 
    130                 135                 140


Glu Ala Leu Pro Glu Ser Thr Asp Ser Ser Leu Glu Asn Leu Pro Leu 
145                 150                 155                 160


Ala Pro Leu Tyr Pro Ser Gln Glu Thr Ser Met Glu Leu Ser Gly Gly 
                165                 170                 175


Lys Gly Glu Gln Lys Glu Ser Pro Gln Ser Ala Ala Ser Leu Leu Gly 
            180                 185                 190


Ser Glu Phe Leu Ser Pro Asn Tyr Glu His Gly Ala Arg Arg Ser Lys 
        195                 200                 205


Pro Phe Ser Glu Leu Ser Asp Ser Asp Leu Glu Glu Lys Ser Ser Ser 
    210                 215                 220


Leu Ser Pro Tyr Val Lys Ser Ser Ser Ser His Asn Glu Val Phe Leu 
225                 230                 235                 240


Pro Gly Ser Arg Gly Pro Arg Arg Arg Lys Ser Lys Gln His Phe Val 
                245                 250                 255


Glu Lys Asn Lys Leu Thr Leu Gly Leu Pro Thr Pro Lys Thr Asp Ser 
            260                 265                 270


Tyr Leu Gln Leu His Asn Lys Lys Arg Gly Glu Ser His Pro Glu Gln 
        275                 280                 285


Val Ile Leu Arg Val Asn Ser Leu Pro Arg Asp Gly Phe Lys Thr Phe 
    290                 295                 300


Trp Ser Gln 
305


<210>  889
<211>  871
<212>  DNA
<213>  Homo sapiens

<400>  889
agaataccag tgctcattaa tattcagcca cccttgcatt tagatgtagc caatatattt     60

atgttgtaag tagattcctt tggttacaat gaaaataaaa gaccacagga gaataagtga    120

taaatcaaca agaccagtta ggatgctatt gcagtatttt tggaaagaaa aactagtaag    180

actagaacag tgagatatgg aaacagaact actttttctg caacaggttg ctggcagaac    240

acaggtgtct tgaaaactat ctctaaagat gctgtgtcgc gccactgtag tggcttcttc    300

ctctgccttt ctcttcctcc gctgtcgcct cccaactcta gtcagcctcc ggccggccgt    360

ctccttaaca cagaacacca tgccttcaat taagttgcag agttctggtg gagagatatt    420

tgaagttgat gtggaaattg tcaaacaatc tgtgactatc aagaccatgt tggaagattt    480

gggaatgaat gatgaaggag atcatgaccc agttcctcta ccaaatgtta atgcagcaat    540

attaaaaaag gtcattcagt ggtgcaccca ccatgaggat gactcacctc ctcccaaagt    600

ttatgaaaac aaagaaaagc gaacagacga tatccctgtt tgggaccaag aatttctgaa    660

agttgaccaa ggaacacttt ttgaactcat tctggctgca aactacttag acatcaaagg    720

tttgcttgat gttacatgca agactgttgc caatatggtc aacaggaaaa ctcctgagga    780

gattcacaag accttcaatt taaaaaatga ctttactgaa gagtgggaag cccaggtaca    840

ccaagagaac cagcagtgtg aagagaagtg a                                   871


<210>  890
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  890

Met Pro Ser Ile Lys Leu Gln Ser Ser Gly Gly Glu Ile Phe Glu Val 
1               5                   10                  15


Asp Val Glu Ile Val Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30


Asp Leu Gly Met Asn Asp Glu Gly Asp His Asp Pro Val Pro Leu Pro 
        35                  40                  45


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60


His Glu Asp Asp Ser Pro Pro Pro Lys Val Tyr Glu Asn Lys Glu Lys 
65                  70                  75                  80


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95


Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Val Asn 
        115                 120                 125


Arg Lys Thr Pro Glu Glu Ile His Lys Thr Phe Asn Leu Lys Asn Asp 
    130                 135                 140


Phe Thr Glu Glu Trp Glu Ala Gln Val His Gln Glu Asn Gln Gln Cys 
145                 150                 155                 160


Glu Glu Lys 



<210>  891
<211>  1413
<212>  DNA
<213>  Homo sapiens

<400>  891
atgggaaagg aaaagactaa tatcaacatt gtcatcactg gacaagtagg ttcaggcaag     60

tccaccacta ctggccatct gatctacaaa tgcattgacg tcgacaaaag aaccattcaa    120

aaatttgaga aggaggctgc ttagatggga aagggctcct tcaagtatgc ttgggtcttg    180

gataaactga aagctaaaca tgaacctggt atcaccattg gtatctccct gtagaaattt    240

gagaccagta agtactacgt gagtatcatt gatgccccag gacacagaga cttcatcaaa    300

aacatgatta cagggacatc tcaggctgac tgtgctgtcc tgattgttgc tgctggtgtt    360

ggtgaatttg aagctggtat ctccaagaat ggacagaccc atgagcatgc ccttctggct    420

tacacactag gtgtgaaaca actaattgtt ggtgttaaca aaatggattc cactgagcaa    480

ccctacagcc agaagacata tgaggaaatc gttaaagaag tcaacactta cattatgaaa    540

attggctgca accttgacac agcagcattt gtgcttattt ctggttgaaa tggtgacaac    600

atactgtagc caagtgctaa catgccttgg tttaagggac tgaaagtcac ctgtaaggat    660

ggcaatacca gtggaacctc actgcttgag gctctggact gcatcctacc accaactcat    720

ccaactaaca agccctttca cctgcttctc taggatatct acaaaaattg gtggtattgg    780

tactgtttct gttggctgag tagagactgg tgttctcaaa ccctgtatgg tgctccagtc    840

aatgttacaa ctgaagtaaa gtctgttgaa atacaccatg aagctttgag tgaagctctt    900

cctggggaca atgtgggctt caatgtcaag aacgtgtctg tcaaggatgt tcgtcatggc    960

aacaatgctg gtgacagcaa aaacgaccca ccaatggaag cagctggctt cactgctcag   1020

gtgattatcc tgaaccatcc aggccaaata agtgctggct atgcccttgt actggattgt   1080

cacacggctc acactgcatg caagtttgct gagctgaagg aaaagattga tcgctgttct   1140

ggtaaaaagc tggaagacgg ccctaaattc ttgaagtctg gtgatgctgc catcatttat   1200

atggttcctg gcaagcccat gtgtgtagag agcttctcag actatccacc tctgggtcac   1260

tttgctgttg gtcatatgag acagacagtt gccatgggta tcatcaaagc agaggacagg   1320

aaggctgctg gagttggcaa ggtcactaag tctgcccaga aagctccaaa gcctagtgaa   1380

tattatccct tgtacctgcc accccagtct taa                                1413


<210>  892
<211>  942
<212>  DNA
<213>  Homo sapiens

<400>  892
gcacccagaa ttctaactag gatcttcaag aacaactctc cccaggtcag tgcatggagc     60

agaaagagaa gggaaaggga tagaatgtct tcatgacttt aatcctagta tttgaaaaaa    120

aaaaatcaaa ccttgcacct acaaatttct gtcttgatcc agaaagtcat tagcataaaa    180

aagataatag tggccttctc acctaacgcc accaacatgg tgttcaggcg cttcgtggag    240

gttggccggg tggcctatgt ctcctttgga cctcatgccg gaaaattggt cgcgattgta    300

gatgttattg atcagaacag ggctttggtc gatggacctt gcactcaagt gaggagacag    360

gccatgcctt tcaagtgcat gcagctcact gatttcatcc tcaagtttcc gcacagtgcc    420

cgccaaaagt atgtccaaca agcctggcag aaggcagaca tcaatacaaa atgggcagcc    480

acacgatggg ccaagaagat tgaagccaga gaaaggaaag ccaagatgac agattttgat    540

cgttttaaag ttatgaaggc aaagaaaacg aggaacagaa taatcaagaa tgaagttaag    600

aagcttcaaa aggcagctct cctgaaagct tctcccaaaa aagcacctgg tactaagggt    660

actgctgctg ctgctgctgc tgctgctgct gctaaagttc cagcaaaaaa gatgacggcc    720

gcgagtaaaa aggcttcagc ccagaaggtt cctgcccaga aagccacagg ccagaaagca    780

gcacctgctc caaaagctca gaagggtcaa aaagctccag cccagaaagc acctgctcca    840

aaggcatctg gcaagaaagc ataagtggca atcataaaaa gtaataaagg ttctttttga    900

cctgttggca aatgtaaaaa aaaaaaaaaa gataatagtg ag                       942


<210>  893
<211>  762
<212>  DNA
<213>  Homo sapiens

<400>  893
cgggtcttca tggccttctc acctaacgcc accaacatgg tgttcaggcg cttcgtggag     60

gttggccggg tggcctatgt ctcctttgga cctcatgccg gaaaattggt cgcgattgta    120

gatgttattg atcagaacag ggctttggtc gatggacctt gcactcaagt gaggagacag    180

gccatgcctt tcaagtgcat gcagctcact gatttcatcc tcaagtttcc gcacagtgcc    240

cgccaaaagt atgtccaaca agcctggcag aaggcagaca tcaatacaaa atgggcagcc    300

acacgatggg ccaagaagat tgaagccaga gaaaggaaag ccaagatgac agattttgat    360

cgttttaaag ttatgaaggc aaagaaaacg aggaacagaa taatcaagaa tgaagttaag    420

aagcttcaaa aggcagctct cctgaaagct tctcccaaaa aagcacctgg tactaagggt    480

actgctgctg ctgctgctgc tgctgctgct gctaaagttc cagcaaaaaa gatgacggcc    540

gcgagtaaaa aggcttcagc ccagaaggtt cctgcccaga aagccacagg ccagaaagca    600

gcacctgctc caaaagctca gaagggtcaa aaagctccag cccagaaagc acctgctcca    660

aaggcatctg gcaagaaagc ataagtggca atcataaaaa gtaataaagg ttctttttga    720

cctgttggca aatgtaaaaa aaaaaaaaaa gataatagtg ag                       762


<210>  894
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  894
atggagacag cgggctctgg tactgggcag ccggcctctc tgctggaggc tcccgggtcc     60

acggatgacc ggcttttcct ggttaaaggt ggaattttcc ttggtactgt tgctgcagca    120

ggaacgctag ctggatttat tacaacatta tcattggcta aaaagaaaag ccctgaatgg    180

ttcaataagg gaagtatggt cacgactgca ttaccggaaa gcgggtcttc ccttgccttg    240

cgagctctgg gctgcggctc actgtatgca tggtgtgggg ttggtgtgat tagcttctca    300

gtctggaaag ctttaggggt tcacagtgac atgtaa                              336


<210>  895
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  895

Met Glu Thr Ala Gly Ser Gly Thr Gly Gln Pro Ala Ser Leu Leu Glu 
1               5                   10                  15


Ala Pro Gly Ser Thr Asp Asp Arg Leu Phe Leu Val Lys Gly Gly Ile 
            20                  25                  30


Phe Leu Gly Thr Val Ala Ala Ala Gly Thr Leu Ala Gly Phe Ile Thr 
        35                  40                  45


Thr Leu Ser Leu Ala Lys Lys Lys Ser Pro Glu Trp Phe Asn Lys Gly 
    50                  55                  60


Ser Met Val Thr Thr Ala Leu Pro Glu Ser Gly Ser Ser Leu Ala Leu 
65                  70                  75                  80


Arg Ala Leu Gly Cys Gly Ser Leu Tyr Ala Trp Cys Gly Val Gly Val 
                85                  90                  95


Ile Ser Phe Ser Val Trp Lys Ala Leu Gly Val His Ser Asp Met 
            100                 105                 110


<210>  896
<211>  1142
<212>  DNA
<213>  Homo sapiens

<400>  896
atgagttgga ctgtacctgt tgtgtgggcc agccagagag tgagctcggc aggagcgaat     60

tttctgtgcc tggggatggc cctgtgtccc cgtcaggcag cgtgcatgcc actcatgggc    120

acctggctct tcacctccgt gagcaagatg gcgactgtga agagtgagct tattgagtgc    180

ttcacttccg aggagccctt tcatcacaga aaggtctcca tcacaggaac tggatcagtg    240

ggcatggcct gcgctaccag catcttatta aaaggcttga gtgatgaact tgcctttgtg    300

gatcttgatg aaggcaaact gaaaggtgag acaatggatc ttcaacatga cagccctttc    360

atgaaaatgt caaatattgt ttgtagcaaa gattaccttg tcacagcaaa cccccatcta    420

gtgattatca cagcaggtgc acgccgagaa aagggagaaa tgcgctttaa tttagtccgg    480

caaaatgtgg ccatcttcaa gttaatgatt tccagtattg tccagcagag ccccctctgc    540

aaactaatta ttgtttccaa tccagtagat atcttaactt acgtagcctg gaagttgagt    600

gcatttccca aaaaccgtgt tattggaagc ggctgtaatc tggatactgt tcgttttcaa    660

ttcttcattg gacaaaagct tggtatccac tctgaaagct gccgtggatg gatcctcgga    720

gagcatggag actcaagtgt tcctgtgtgg agtggaatga acatagctgg tgtccttttg    780

aaggatctga actctgatat aggaactgat aaagatcctg agaaatggaa aaatgtccac    840

aaagaagtga ttgctagtgc ctatgagatt attgaaatga aaagttctac ttcgtgggcc    900

attggcctat ctggagctga tttaacagaa agtattttga agaatcttag gagaaaacat    960

ccagtttcca ccataattaa gggcctctac ggaataaatg aagaagtctt cctcagtatt   1020

ccttctttgg agagaagggt attaccaacc ttataaagag aaagctgacc cctgaagagg   1080

aggcccatct gaaaaagagt gcaaaaacac tttgggaaat tcagaaggag cttgagactt   1140

aa                                                                  1142


<210>  897
<211>  1061
<212>  DNA
<213>  Homo sapiens

<400>  897
aggccgaggc gggggtggag gggtccatac ggcgctgttc tggattcccg ttgtaactta     60

aagggaaact ttcacaatgt ccggagccct tgatgtcctg caaatgaggg aggaggatgt    120

ccttaagttc cttgcagcag gaacccactt aggtggcacc aatcttgact tccagatgga    180

acagtacatc tatgaaagga aaagtgatgg catctatatc ataaatctga agaggacctg    240

ggagaagctt ctgctggcag ctcatgctat tgttgccatt gaaaaccctg ctgatgtcag    300

tgttatatcc tccaggaata ctggccagac ggctgtgctg aagtttgctg ctgccactgg    360

agccactcca attgctgggc gcttcactcc tggaaccttc actaaccaga tccaggcagc    420

cttccgggag ccacggcttc ttgtggttac tgaccccagg gctgaccacc agcctctcac    480

ggaggcatct tatgttaacc tacctaccat tgcgctgtgt aacacagatt ctcctctgcg    540

ctatgtggac attgccatcc catgcaacaa caagggagct tactcagtgg gtttgatgtg    600

gtggatgctg gctcgggaag ttctgtgcat gcttggcacc atttcctgtg aacacccatg    660

ggaggtcatg cctgatctgt acttctacag agatcctgaa gagattgaaa aagaagagca    720

ggctgctgct gaaaaggcag tgaccaagga ggaatttcag ggtgaatgga ctgctccagc    780

tcctgagttc actgctattc agcctgaggt tgcagactgg tctgaaggtg tacaggtgcc    840

ctctgtgcct attcagcaat tccctactga agactggagc tctcagcctg ccatggaaga    900

ctggtctgca gctcccactg ctcaggccac tgaatgggta ggagcaacca ctgactggtc    960

ttaagctgtt cttgcatagg ctcttaagca gcatggaaaa atggttgatg gaaaataagc   1020

atcagtttct aaaaaaaaaa aaagaataat ttgacttctt c                       1061


<210>  898
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  898

Met Ser Gly Ala Leu Asp Val Leu Gln Met Arg Glu Glu Asp Val Leu 
1               5                   10                  15


Lys Phe Leu Ala Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe 
            20                  25                  30


Gln Met Glu Gln Tyr Ile Tyr Glu Arg Lys Ser Asp Gly Ile Tyr Ile 
        35                  40                  45


Ile Asn Leu Lys Arg Thr Trp Glu Lys Leu Leu Leu Ala Ala His Ala 
    50                  55                  60


Ile Val Ala Ile Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg 
65                  70                  75                  80


Asn Thr Gly Gln Thr Ala Val Leu Lys Phe Ala Ala Ala Thr Gly Ala 
                85                  90                  95


Thr Pro Ile Ala Gly Arg Phe Thr Pro Gly Thr Phe Thr Asn Gln Ile 
            100                 105                 110


Gln Ala Ala Phe Arg Glu Pro Arg Leu Leu Val Val Thr Asp Pro Arg 
        115                 120                 125


Ala Asp His Gln Pro Leu Thr Glu Ala Ser Tyr Val Asn Leu Pro Thr 
    130                 135                 140


Ile Ala Leu Cys Asn Thr Asp Ser Pro Leu Arg Tyr Val Asp Ile Ala 
145                 150                 155                 160


Ile Pro Cys Asn Asn Lys Gly Ala Tyr Ser Val Gly Leu Met Trp Trp 
                165                 170                 175


Met Leu Ala Arg Glu Val Leu Cys Met Leu Gly Thr Ile Ser Cys Glu 
            180                 185                 190


His Pro Trp Glu Val Met Pro Asp Leu Tyr Phe Tyr Arg Asp Pro Glu 
        195                 200                 205


Glu Ile Glu Lys Glu Glu Gln Ala Ala Ala Glu Lys Ala Val Thr Lys 
    210                 215                 220


Glu Glu Phe Gln Gly Glu Trp Thr Ala Pro Ala Pro Glu Phe Thr Ala 
225                 230                 235                 240


Ile Gln Pro Glu Val Ala Asp Trp Ser Glu Gly Val Gln Val Pro Ser 
                245                 250                 255


Val Pro Ile Gln Gln Phe Pro Thr Glu Asp Trp Ser Ser Gln Pro Ala 
            260                 265                 270


Met Glu Asp Trp Ser Ala Ala Pro Thr Ala Gln Ala Thr Glu Trp Val 
        275                 280                 285


Gly Ala Thr Thr Asp Trp Ser 
    290                 295


<210>  899
<211>  2117
<212>  DNA
<213>  Homo sapiens

<400>  899
gcgaggctga acgcctgacg tcaaggcgac atcgccaaac ctcgcccaga ttcaggcgtg     60

taaaccagcc ggagcggcgc ggcagcggca ggaccgccgt ggcgcctaga gtagcgaccc    120

ggggggagcg cggggcgacg ctggctgcag ggacccggtg acagcgtgag aggtactagg    180

ttttgacaag cttgcatcat gcgtgagtat aagctagtcg ttcttggctc aggaggcgtt    240

ggaaagtctg ctttgactgt acaatttgtt caaggaattt ttgtagaaaa atacgatcct    300

acgatagaag attcttatag aaagcaagtt gaagtagatg cacaacagtg tatgcttgaa    360

atcttggata ctgcaggaac ggagcaattt acagcaatga gggatttata catgaaaaat    420

ggacaaggat ttgcattagt ttattccatc acagcacagt ccacatttaa cgatttacaa    480

gacctgagag aacagattct tcgagttaaa gacactgatg atgttccaat gattcttgtt    540

ggtaataagt gtgacttgga agatgaaaga gttgtaggga aggaacaagg tcaaaatcta    600

gcaagacaat ggaacaactg tgcattctta gaatcttctg caaaatcaaa aataaatgtt    660

aatgagatct tttatgacct agtgcggcaa attaacagaa aaactccagt gcctgggaag    720

gctcgcaaaa agtcatcatg tcagctgctt taatatacta aatgcattgt agctctgagc    780

caggtctgaa gaactgttgc ccaattcaac agtgccagca ttccaacttt gttaaaccta    840

ccaacatctt aaatggactt tcctgtggtg gtacccttta agaggcggat gaaagctact    900

atatcagttt gcacattcta atcactttcc agtatcacaa gagagatttt tacttatata    960

atagtcctag agtttgcagc tggtaaaacc agaggctaca tccagtatta ctgctaagag   1020

acattcttca tccaccaatg ttgtacatgt atgaaaatgg tgtactgtat actttaacat   1080

gccccatact ttgtattgga gagtacaata atgtaaatcc taaaagcacc actattttag   1140

cataataaaa gaaagtccaa agagctccta tatagactac tccagataac ttcgcttctt   1200

tgatacttgt agcttattgt aatttttttt aagaaattca aggtcattat tattgtacaa   1260

aataagcgct ttgattaaca cagctatata gtttttttaa tttttaaaaa acctgtggag   1320

acggtgatct tgtctttaaa acatgatagt cctttcagta taatgtctta gattaaagac   1380

gttgccttta atatctgttg ggaaggaaat gtccagactt ttcaaatctc ttattatatg   1440

tttccttttt ttgtttacat agggaacaat gtttatagtc gtgtgtacag tgggggtcta   1500

caacaagaag tgtatatttt caaacaattt tttaatgatt taacaatttt tgtaaatcat   1560

tttcaggctt ctgcagctgt agattctcac tgtgaatccc ttgcttgctc atgcataagt   1620

gtatttgcaa taccaaatat acaggtttag tatttttgcc tgttagtgat tgtttcacat   1680

gtgtaacgtt ttggttgaga tgttaaatgg tggacgagta ctgtggatgt gaatgtggga   1740

agtaatttta atcatatgta attggtcaca aggcctaatt tgcagtaact attgctgttt   1800

tatttaacaa tgccttgttg ctttgtatgc attaatgttt ggatgtaaag attgtgtgtc   1860

tatccaacag ggagccacag tatttaaatt gaccaaccta atgttacaac tactttgagg   1920

tggccaaatg taaactaaaa gccttaatta aagtggtgca attttgtata acttagcatc   1980

agtagttcaa taaatttgga ttgccatgca agggcttgca ttataattac ttgccacttg   2040

aatgtgtttt gtgtaatgtt ttaacagtgc tagtaaataa atacgggttt accctggtaa   2100

aaaaaaaaaa aaaaaaa                                                  2117


<210>  900
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  900

Met Arg Glu Tyr Lys Leu Val Val Leu Gly Ser Gly Gly Val Gly Lys 
1               5                   10                  15


Ser Ala Leu Thr Val Gln Phe Val Gln Gly Ile Phe Val Glu Lys Tyr 
            20                  25                  30


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Glu Val Asp Ala 
        35                  40                  45


Gln Gln Cys Met Leu Glu Ile Leu Asp Thr Ala Gly Thr Glu Gln Phe 
    50                  55                  60


Thr Ala Met Arg Asp Leu Tyr Met Lys Asn Gly Gln Gly Phe Ala Leu 
65                  70                  75                  80


Val Tyr Ser Ile Thr Ala Gln Ser Thr Phe Asn Asp Leu Gln Asp Leu 
                85                  90                  95


Arg Glu Gln Ile Leu Arg Val Lys Asp Thr Asp Asp Val Pro Met Ile 
            100                 105                 110


Leu Val Gly Asn Lys Cys Asp Leu Glu Asp Glu Arg Val Val Gly Lys 
        115                 120                 125


Glu Gln Gly Gln Asn Leu Ala Arg Gln Trp Asn Asn Cys Ala Phe Leu 
    130                 135                 140


Glu Ser Ser Ala Lys Ser Lys Ile Asn Val Asn Glu Ile Phe Tyr Asp 
145                 150                 155                 160


Leu Val Arg Gln Ile Asn Arg Lys Thr Pro Val Pro Gly Lys Ala Arg 
                165                 170                 175


Lys Lys Ser Ser Cys Gln Leu Leu 
            180


<210>  901
<211>  2126
<212>  DNA
<213>  Homo sapiens

<400>  901
gcgaggctga acgcctgacg tcaaggcgac atcgccaaac ctcgcccaga ttcaggcgtg     60

taaaccagcc ggagcggcgc ggcagcggca ggaccgccgt ggcgcctaga gtagcgaccc    120

ggggggagcg cggggcgacg ctggctgcag ggacccggtg acagcgtgag aggttcgcag    180

agtactaggt tttgacaagc ttgcatcatg cgtgagtata agctagtcgt tcttggctca    240

ggaggcgttg gaaagtctgc tttgactgta caatttgttc aaggaatttt tgtagaaaaa    300

tacgatccta cgatagaaga ttcttataga aagcaagttg aagtagatgc acaacagtgt    360

atgcttgaaa tcttggatac tgcaggaacg gagcaattta cagcaatgag ggatttatac    420

atgaaaaatg gacaaggatt tgcattagtt tattccatca cagcacagtc cacatttaac    480

gatttacaag acctgagaga acagattctt cgagttaaag acactgatga tgttccaatg    540

attcttgttg gtaataagtg tgacttggaa gatgaaagag ttgtagggaa ggaacaaggt    600

caaaatctag caagacaatg gaacaactgt gcattcttag aatcttctgc aaaatcaaaa    660

ataaatgtta atgagatctt ttatgaccta gtgcggcaaa ttaacagaaa aactccagtg    720

cctgggaagg ctcgcaaaaa gtcatcatgt cagctgcttt aatatactaa atgcattgta    780

gctctgagcc aggtctgaag aactgttgcc caattcaaca gtgccagcat tccaactttg    840

ttaaacctac caacatctta aatggacttt cctgtggtgg taccctttaa gaggcggatg    900

aaagctacta tatcagtttg cacattctaa tcactttcca gtatcacaag agagattttt    960

acttatataa tagtcctaga gtttgcagct ggtaaaacca gaggctacat ccagtattac   1020

tgctaagaga cattcttcat ccaccaatgt tgtacatgta tgaaaatggt gtactgtata   1080

ctttaacatg ccccatactt tgtattggag agtacaataa tgtaaatcct aaaagcacca   1140

ctattttagc ataataaaag aaagtccaaa gagctcctat atagactact ccagataact   1200

tcgcttcttt gatacttgta gcttattgta atttttttta agaaattcaa ggtcattatt   1260

attgtacaaa ataagcgctt tgattaacac agctatatag tttttttaat ttttaaaaaa   1320

cctgtggaga cggtgatctt gtctttaaaa catgatagtc ctttcagtat aatgtcttag   1380

attaaagacg ttgcctttaa tatctgttgg gaaggaaatg tccagacttt tcaaatctct   1440

tattatatgt ttcctttttt tgtttacata gggaacaatg tttatagtcg tgtgtacagt   1500

gggggtctac aacaagaagt gtatattttc aaacaatttt ttaatgattt aacaattttt   1560

gtaaatcatt ttcaggcttc tgcagctgta gattctcact gtgaatccct tgcttgctca   1620

tgcataagtg tatttgcaat accaaatata caggtttagt atttttgcct gttagtgatt   1680

gtttcacatg tgtaacgttt tggttgagat gttaaatggt ggacgagtac tgtggatgtg   1740

aatgtgggaa gtaattttaa tcatatgtaa ttggtcacaa ggcctaattt gcagtaacta   1800

ttgctgtttt atttaacaat gccttgttgc tttgtatgca ttaatgtttg gatgtaaaga   1860

ttgtgtgtct atccaacagg gagccacagt atttaaattg accaacctaa tgttacaact   1920

actttgaggt ggccaaatgt aaactaaaag ccttaattaa agtggtgcaa ttttgtataa   1980

cttagcatca gtagttcaat aaatttggat tgccatgcaa gggcttgcat tataattact   2040

tgccacttga atgtgttttg tgtaatgttt taacagtgct agtaaataaa tacgggttta   2100

ccctggtaaa aaaaaaaaaa aaaaaa                                        2126


<210>  902
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  902

Met Arg Glu Tyr Lys Leu Val Val Leu Gly Ser Gly Gly Val Gly Lys 
1               5                   10                  15


Ser Ala Leu Thr Val Gln Phe Val Gln Gly Ile Phe Val Glu Lys Tyr 
            20                  25                  30


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Glu Val Asp Ala 
        35                  40                  45


Gln Gln Cys Met Leu Glu Ile Leu Asp Thr Ala Gly Thr Glu Gln Phe 
    50                  55                  60


Thr Ala Met Arg Asp Leu Tyr Met Lys Asn Gly Gln Gly Phe Ala Leu 
65                  70                  75                  80


Val Tyr Ser Ile Thr Ala Gln Ser Thr Phe Asn Asp Leu Gln Asp Leu 
                85                  90                  95


Arg Glu Gln Ile Leu Arg Val Lys Asp Thr Asp Asp Val Pro Met Ile 
            100                 105                 110


Leu Val Gly Asn Lys Cys Asp Leu Glu Asp Glu Arg Val Val Gly Lys 
        115                 120                 125


Glu Gln Gly Gln Asn Leu Ala Arg Gln Trp Asn Asn Cys Ala Phe Leu 
    130                 135                 140


Glu Ser Ser Ala Lys Ser Lys Ile Asn Val Asn Glu Ile Phe Tyr Asp 
145                 150                 155                 160


Leu Val Arg Gln Ile Asn Arg Lys Thr Pro Val Pro Gly Lys Ala Arg 
                165                 170                 175


Lys Lys Ser Ser Cys Gln Leu Leu 
            180


<210>  903
<211>  1107
<212>  DNA
<213>  Homo sapiens

<400>  903
ccaggctggt ctcaaactcc tggcctcaaa agtgatcctc ctgccttggc ctcccaaagt     60

gttgggattt caggaatgag tcaccactgt ctggcccatt ttcattttct ataaagcaag    120

gctatctacc aaaacttagg tctgtttttt cagtatactg gggagtctct ctaaagataa    180

attaacatac cctgtacatc tatctatatg ataaaagacg cttttagtta ggtattatgt    240

ttctgttaga tgtagtttgg ctggtatggg tcacattcca gcatgacgtg aagtaaggag    300

ctacacatgg ggtatttcga aaagtgggta aaacaaaagt cacgctggga ataacgagag    360

gtgaagtttc aaggtcaggt caaatttaaa tgtgaaggcc cagaagcccg ggagacctaa    420

tcaattttaa agtagtggtt ggctaccaaa ccatttatac tcctaacact attattagta    480

aaatctctca ttctagtagg gattgggtat atttgtgtgt tttaaaaaac accctgctgc    540

agcctattaa gccaactgag ttcctttcct catggggggg cccagtgtgc aatggctgca    600

aacagcagct tccttggtag tgtatgcagc ctgtgtgttg tattgtatgg gttgctctaa    660

gggaccctgg agacagtcct ttcagatgga tgttcatgtt tctgaccttg cactacccca    720

gtgtaggttc caaacaggca tgcgaggtgc ctttgggaag ccccagggca ctgtggccag    780

ggttcacact ggccaagtta tcatctccat tcacaccaag ctgcagaaca aggagcatgt    840

gattgaggcc ctgcgcaggg ccaagttcaa gttttctggc cgccagaaga tccacatctc    900

aaagaagtgg ggcttcacca agttcaatgc caatgagttt gaagacatgg tgactgagaa    960

gcggctcatc ccagatggct gtcgggtcaa gtacatttcc aatcgtggcc ctgtggacaa   1020

gtggcgggcc ctgcactcat gagggcttcc actgtgctgc cccctcttaa tactcaccaa   1080

taaattctac ttcctgtcca cccaaaa                                       1107


<210>  904
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  904

Met Asp Val His Val Ser Asp Leu Ala Leu Pro Gln Cys Arg Phe Gln 
1               5                   10                  15


Thr Gly Met Arg Gly Ala Phe Gly Lys Pro Gln Gly Thr Val Ala Arg 
            20                  25                  30


Val His Thr Gly Gln Val Ile Ile Ser Ile His Thr Lys Leu Gln Asn 
        35                  40                  45


Lys Glu His Val Ile Glu Ala Leu Arg Arg Ala Lys Phe Lys Phe Ser 
    50                  55                  60


Gly Arg Gln Lys Ile His Ile Ser Lys Lys Trp Gly Phe Thr Lys Phe 
65                  70                  75                  80


Asn Ala Asn Glu Phe Glu Asp Met Val Thr Glu Lys Arg Leu Ile Pro 
                85                  90                  95


Asp Gly Cys Arg Val Lys Tyr Ile Ser Asn Arg Gly Pro Val Asp Lys 
            100                 105                 110


Trp Arg Ala Leu His Ser 
        115


<210>  905
<211>  3158
<212>  DNA
<213>  Homo sapiens

<400>  905
gttttaggga cagactgctt ccgggtcgaa gggcttgctt ccggagagcg ggaaggctaa     60

aacgcggtag ctaaactgca gccaactttg gttgtgtgtg gaaaaggctt tagccatgga    120

caggagtggc tttggagaga tatcatcccc tgtaatccgg gaggcagagg tgacacggac    180

tgcacggaaa cagagtgctc agaaaagagt tttacttcag gcatctcaag atgaaaattt    240

tggtaatact acaccaagaa accaggttat ccctcgaact cctagctcat ttcgacagcc    300

ttttacccca acaagccgaa gcttactaag gcagccagat atttcctgca ttcttggaac    360

aggagggaag tcgccccgac ttacgcagtc ttcagggttc tttggaaatc tctccatggt    420

tactaatctg gatgacagta actgggcagc tgcattttca tcacagcgtt ccgggctgtt    480

cacaaacaca gagccccaca gtataacaga agatgtaact atcagtgctg ttatgttacg    540

tgaggatgat cctggagaag ctgcatccat gagtatgttt tctgatttcc tgcagtcttt    600

tctgaagcac tcttcgagta cagtttttga tcttgtggaa gagtatgaaa acatctgtgg    660

tagtcaggtg aatatactga gtaaaatagt gagtcgagca acacctggac ttcaaaaatt    720

ttcaaaaaca gccagtatgc tctggcttct tcaacaggag atggtcacat ggaggctgct    780

ggcttctttg tatagagaca gaatacagtc tgcattagaa gaggaaagtg tattcgcagt    840

tactgctgtt aatgccagtg aaaaaacagt tgtggaagcg ttatttcaga gggattcact    900

tgttcgacaa agtcagctgg tggtagattg gttagagagt attgccaaag atgaaattgg    960

agaattttct gataatattg agttttatgc aaaatcagta tattgggaaa atactctgca   1020

taccttaaaa caacggcagc tgacttctta cgttggaagt gttcgtccgc ttgtcactga   1080

attggaccct gatgctccca taagacagaa aatgcccctt gatgatctgg atagagaaga   1140

tgaagttaga ttactcaaat atctctttac tctaatccgt gctggaatga cagaagaggc   1200

acaacgactc tgtaaacgct gtggtcaagc atggagagct gcaacacttg aaggctggaa   1260

actgtaccat gaccctaatg ttaatggagg aacagaatta gaacctgttg aagggaatcc   1320

atatagacgc atttggaaaa taagttgctg gagaatggca gaagatgagc tttttaatag   1380

atacgagaga gcaatttatg cagctttaag tgggaatctt aagcagctgc ttcctgtctg   1440

tgacacctgg gaagacacag tttgggccta cttccgggtg atggtggaca gtctggtaga   1500

acaggagatc cagacatcag tagcaactct ggatgaaact gaagaactcc ctagagaata   1560

tctgggagca aactggacgt tagaaaaggt ttttgaggaa cttcaagcta ctgacaaaaa   1620

gagagttctg gaagagaatc aagaacatta tcatatagtt caaaagtttc ttatcctggg   1680

agacattgat ggtttgatgg atgagtttag caaatggctt tccaaaagca gaaacaatct   1740

acctggacac ctgcttcgct ttatgactca ccttattttg tttttccgta ctctgggact   1800

acagaccaag gaggaagttt ctattgaagt tttaaagaca tacatacagc ttttaataag   1860

agagaaacat acaaatctta tagcatttta tacctgtcat ttgcctcaag acctagctgt   1920

tgcccagtat gcattatttt tggaaagtgt tacagaattt gaacagcgcc accattgcct   1980

ggagttggct aaagaagcag atttggatgt tgcaacaata acaaaaactg tagttgagaa   2040

tattcgaaag aaagataatg gtgaatttag tcatcatgac ctggccccag ccctagatac   2100

tggcactact gaggaggatc gtttaaaaat tgatgtaatt gactggttgg tatttgaccc   2160

agcgcagagg gcagaagcac tgaaacaagg caatgcaatt atgagaaaat tcttggcatc   2220

aaaaaagcac gaagctgcaa aagaagtatt tgtgaaaatt cctcaggatt ctatagcaga   2280

aatctataat cagtgcgagg aacaaggaat ggaaagtcca cttcctgctg aagatgataa   2340

tgctatccga gaacatttgt gcatcagagc ttatttggaa gcccatgaaa cctttaatga   2400

gtggtttaag catatgaatt cagttccaca aaaacctgct ttgatacctc aaccaacttt   2460

tactgagaaa gtggctcatg aacacaaaga aaagaaatat gaaatggatt ttggtatttg   2520

gaaagggcat ttggatgccc taactgctga tgtgaaggag aaaatgtata acgtcttgtt   2580

gtttgttgat ggagggtgga tggtggatgt tagagaggat gccaaagaag accatgaaag   2640

aacacatcaa atggtcttac tgagaaagct ttgtctgcca atgttgtgtt ttctgcttca   2700

tacgatattg cacagtactg gtcagtatca ggaatgccta cagttagcag atatggtatc   2760

ctctgagcgc cacaaactgt acctggtatt ttctaaggaa gagctaagga agttgctgca   2820

gaagctcaga gagtcctctc taatgctcct agaccaggga cttgacccat tagggtatga   2880

aattcagtta tagtttaatc tttgtaatct cactaatttt catgataaat gaagttttta   2940

ataaaatata cttgttatta gtaatttttt cttttgcatt accatgtaaa atttagacat   3000

ttgaattttg tacttttcag aatattatcg tgacactttc aacatgtagg gatatcagcg   3060

tttctctgtg tgcttgttaa taaaactata taaaaattaa aattttctgt ttttacaaat   3120

tccaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                           3158


<210>  906
<211>  925
<212>  PRT
<213>  Homo sapiens

<400>  906

Met Asp Arg Ser Gly Phe Gly Glu Ile Ser Ser Pro Val Ile Arg Glu 
1               5                   10                  15


Ala Glu Val Thr Arg Thr Ala Arg Lys Gln Ser Ala Gln Lys Arg Val 
            20                  25                  30


Leu Leu Gln Ala Ser Gln Asp Glu Asn Phe Gly Asn Thr Thr Pro Arg 
        35                  40                  45


Asn Gln Val Ile Pro Arg Thr Pro Ser Ser Phe Arg Gln Pro Phe Thr 
    50                  55                  60


Pro Thr Ser Arg Ser Leu Leu Arg Gln Pro Asp Ile Ser Cys Ile Leu 
65                  70                  75                  80


Gly Thr Gly Gly Lys Ser Pro Arg Leu Thr Gln Ser Ser Gly Phe Phe 
                85                  90                  95


Gly Asn Leu Ser Met Val Thr Asn Leu Asp Asp Ser Asn Trp Ala Ala 
            100                 105                 110


Ala Phe Ser Ser Gln Arg Ser Gly Leu Phe Thr Asn Thr Glu Pro His 
        115                 120                 125


Ser Ile Thr Glu Asp Val Thr Ile Ser Ala Val Met Leu Arg Glu Asp 
    130                 135                 140


Asp Pro Gly Glu Ala Ala Ser Met Ser Met Phe Ser Asp Phe Leu Gln 
145                 150                 155                 160


Ser Phe Leu Lys His Ser Ser Ser Thr Val Phe Asp Leu Val Glu Glu 
                165                 170                 175


Tyr Glu Asn Ile Cys Gly Ser Gln Val Asn Ile Leu Ser Lys Ile Val 
            180                 185                 190


Ser Arg Ala Thr Pro Gly Leu Gln Lys Phe Ser Lys Thr Ala Ser Met 
        195                 200                 205


Leu Trp Leu Leu Gln Gln Glu Met Val Thr Trp Arg Leu Leu Ala Ser 
    210                 215                 220


Leu Tyr Arg Asp Arg Ile Gln Ser Ala Leu Glu Glu Glu Ser Val Phe 
225                 230                 235                 240


Ala Val Thr Ala Val Asn Ala Ser Glu Lys Thr Val Val Glu Ala Leu 
                245                 250                 255


Phe Gln Arg Asp Ser Leu Val Arg Gln Ser Gln Leu Val Val Asp Trp 
            260                 265                 270


Leu Glu Ser Ile Ala Lys Asp Glu Ile Gly Glu Phe Ser Asp Asn Ile 
        275                 280                 285


Glu Phe Tyr Ala Lys Ser Val Tyr Trp Glu Asn Thr Leu His Thr Leu 
    290                 295                 300


Lys Gln Arg Gln Leu Thr Ser Tyr Val Gly Ser Val Arg Pro Leu Val 
305                 310                 315                 320


Thr Glu Leu Asp Pro Asp Ala Pro Ile Arg Gln Lys Met Pro Leu Asp 
                325                 330                 335


Asp Leu Asp Arg Glu Asp Glu Val Arg Leu Leu Lys Tyr Leu Phe Thr 
            340                 345                 350


Leu Ile Arg Ala Gly Met Thr Glu Glu Ala Gln Arg Leu Cys Lys Arg 
        355                 360                 365


Cys Gly Gln Ala Trp Arg Ala Ala Thr Leu Glu Gly Trp Lys Leu Tyr 
    370                 375                 380


His Asp Pro Asn Val Asn Gly Gly Thr Glu Leu Glu Pro Val Glu Gly 
385                 390                 395                 400


Asn Pro Tyr Arg Arg Ile Trp Lys Ile Ser Cys Trp Arg Met Ala Glu 
                405                 410                 415


Asp Glu Leu Phe Asn Arg Tyr Glu Arg Ala Ile Tyr Ala Ala Leu Ser 
            420                 425                 430


Gly Asn Leu Lys Gln Leu Leu Pro Val Cys Asp Thr Trp Glu Asp Thr 
        435                 440                 445


Val Trp Ala Tyr Phe Arg Val Met Val Asp Ser Leu Val Glu Gln Glu 
    450                 455                 460


Ile Gln Thr Ser Val Ala Thr Leu Asp Glu Thr Glu Glu Leu Pro Arg 
465                 470                 475                 480


Glu Tyr Leu Gly Ala Asn Trp Thr Leu Glu Lys Val Phe Glu Glu Leu 
                485                 490                 495


Gln Ala Thr Asp Lys Lys Arg Val Leu Glu Glu Asn Gln Glu His Tyr 
            500                 505                 510


His Ile Val Gln Lys Phe Leu Ile Leu Gly Asp Ile Asp Gly Leu Met 
        515                 520                 525


Asp Glu Phe Ser Lys Trp Leu Ser Lys Ser Arg Asn Asn Leu Pro Gly 
    530                 535                 540


His Leu Leu Arg Phe Met Thr His Leu Ile Leu Phe Phe Arg Thr Leu 
545                 550                 555                 560


Gly Leu Gln Thr Lys Glu Glu Val Ser Ile Glu Val Leu Lys Thr Tyr 
                565                 570                 575


Ile Gln Leu Leu Ile Arg Glu Lys His Thr Asn Leu Ile Ala Phe Tyr 
            580                 585                 590


Thr Cys His Leu Pro Gln Asp Leu Ala Val Ala Gln Tyr Ala Leu Phe 
        595                 600                 605


Leu Glu Ser Val Thr Glu Phe Glu Gln Arg His His Cys Leu Glu Leu 
    610                 615                 620


Ala Lys Glu Ala Asp Leu Asp Val Ala Thr Ile Thr Lys Thr Val Val 
625                 630                 635                 640


Glu Asn Ile Arg Lys Lys Asp Asn Gly Glu Phe Ser His His Asp Leu 
                645                 650                 655


Ala Pro Ala Leu Asp Thr Gly Thr Thr Glu Glu Asp Arg Leu Lys Ile 
            660                 665                 670


Asp Val Ile Asp Trp Leu Val Phe Asp Pro Ala Gln Arg Ala Glu Ala 
        675                 680                 685


Leu Lys Gln Gly Asn Ala Ile Met Arg Lys Phe Leu Ala Ser Lys Lys 
    690                 695                 700


His Glu Ala Ala Lys Glu Val Phe Val Lys Ile Pro Gln Asp Ser Ile 
705                 710                 715                 720


Ala Glu Ile Tyr Asn Gln Cys Glu Glu Gln Gly Met Glu Ser Pro Leu 
                725                 730                 735


Pro Ala Glu Asp Asp Asn Ala Ile Arg Glu His Leu Cys Ile Arg Ala 
            740                 745                 750


Tyr Leu Glu Ala His Glu Thr Phe Asn Glu Trp Phe Lys His Met Asn 
        755                 760                 765


Ser Val Pro Gln Lys Pro Ala Leu Ile Pro Gln Pro Thr Phe Thr Glu 
    770                 775                 780


Lys Val Ala His Glu His Lys Glu Lys Lys Tyr Glu Met Asp Phe Gly 
785                 790                 795                 800


Ile Trp Lys Gly His Leu Asp Ala Leu Thr Ala Asp Val Lys Glu Lys 
                805                 810                 815


Met Tyr Asn Val Leu Leu Phe Val Asp Gly Gly Trp Met Val Asp Val 
            820                 825                 830


Arg Glu Asp Ala Lys Glu Asp His Glu Arg Thr His Gln Met Val Leu 
        835                 840                 845


Leu Arg Lys Leu Cys Leu Pro Met Leu Cys Phe Leu Leu His Thr Ile 
    850                 855                 860


Leu His Ser Thr Gly Gln Tyr Gln Glu Cys Leu Gln Leu Ala Asp Met 
865                 870                 875                 880


Val Ser Ser Glu Arg His Lys Leu Tyr Leu Val Phe Ser Lys Glu Glu 
                885                 890                 895


Leu Arg Lys Leu Leu Gln Lys Leu Arg Glu Ser Ser Leu Met Leu Leu 
            900                 905                 910


Asp Gln Gly Leu Asp Pro Leu Gly Tyr Glu Ile Gln Leu 
        915                 920                 925


<210>  907
<211>  3033
<212>  DNA
<213>  Homo sapiens

<400>  907
gcccccgccc cctactccct tccctcaggc cccaggaagt tgcaagagta ccatttgtcg     60

cacactcggg gaccgcgggt ggccggagga gatgaaaccg tcttggctgc agtgtcgtaa    120

agtcaccagc gccggggggc tcggagggcc cttgcctggg tcctctccgg cccggggagc    180

cggtgcggcc ctcagggctt tagtggtccc gggcccgcgg ggcggtctcg ggggccgggg    240

atgcagggca ctgtcctccg gcagtggcag cgagtacaag acccacttcg cagcctcggt    300

gaccgacccc gagaggttct ggggcaaagc tgccgagcag atcagctggt acaagccctg    360

gaccaaaacg ctggagaaca aacactcgcc ctctaccagg tggtttgtgg aaggaatgct    420

taacatttgt tacaatgccg ttgatcgtca tattgaaaat ggtaaagggg ataagattgc    480

tatcatctat gacagtcctg ttacaaacac taaagcaacc tttacctata aagaagttct    540

ggagcaggtc tccaagctgg ctggtgtctt ggtcaagcat ggcatcaaga aaggtgacac    600

tgtggttatc tacatgccta tgatcccaca ggcgatgtat accatgttgg catgtgcaag    660

gataggtgcc atccacagtc tcatatttgg aggatttgct tccaaagaac taagtagtcg    720

cattgatcat gtaaagccca aggtggttgt tacagcatca tttggcattg aacctggaag    780

gagggtagag tacgtaccac ttgtagaaga agcgctaaaa ataggacaac acaaaccaga    840

caaaattctc atttataatc gtccaaatat ggaggcggtt cctttggctc ccggtcgtga    900

ccttgattgg gatgaagaga tggcaaaagc ccagtcacat gactgtgttc ctgttctttc    960

agaacaccca ctgtatattc tttacacatc tggcacaacg gggttaccta agggtgtgat   1020

taggcccact gggggatacg ctgtcatgct acactggtca atgtcttcca tatacggact   1080

tcaacccgga gaggtgtggt gggcagcttc tgacttaggc tgggttgttg gacattccta   1140

tatctgctat ggacctcttc ttcatgggaa cacaacagtt ttatatgagg ggaagcctgt   1200

gggaacacca gatgctggcg cttatttccg tgtgcttgca gagcatggag tagctgcctt   1260

gtttacagca ccaactgcaa ttagagcaat ccgtcaacag gaccctgggg cagctttggg   1320

gaagcagtac tctctgacaa ggttcaaaac attatttgtg gctggagaac gatgtgatgt   1380

agagaccctg gaatggtcca aaaatgtctt cagagtacct gtcttagacc attggtggca   1440

aactgagact ggatctccaa ttactgcgtc atgtgttgga ttaggcaatt ctaaaacacc   1500

tccaccaggg caagcaggaa aaagcgtccc aggatacaat gttatgattt tggatgacaa   1560

catgcaaaaa ctgaaggctc ggtgtttagg aaatattgtg gtaaagttac cattgccacc   1620

tggggctttt tcaggactct ggaagaatca ggaagcattc aagcatttat actttgaaaa   1680

atttcctgga tattatgata ccatggatgc tggttacatg gatgaagaag gctatttgta   1740

tgttatgtct cgagtggatg atgtaataaa tgttgcaggt cacagaattt ctgcaggcgc   1800

cattgaagag tcaatccttt cccatggtac cgtggcagac tgtgctgttg ttggcaagga   1860

agatccctta aaaggtcatg tccccttagc actctgtgta ttgagaaaag atataaatgc   1920

aacagaggag caagttttgg aagaaattgt gaaacacgtt agacagaaca ttggccctgt   1980

ggctgctttt cgaaatgcag tgtttgtcaa acagctaccc aaaaccagat ctggcaagat   2040

cccccgatca gctttatctg ccattgtcaa tggcaagcca tacaagataa cttctacaat   2100

tgaagacccc agcatttttg gccacgtaga agaaatgctg aagcaagcat aatgagtttg   2160

tcttattcct attttgagtt gatttaattt cttaattgaa attaaattat ttgagttgtt   2220

tctcagaaat aaatatttca gtagaaatta cttgcaaaat gaaatgtgaa ttgtaaaact   2280

tggcctaaac aaatctaatg aaaacatgtg aaagacctgt gccttttttt tggtttgacc   2340

ctgttagcat tgttattagt tatctataac atggcttatt gaatgtcatc tactgcttta   2400

ggaaaaacgt atctagtgta ttatttttaa aattgtacct cccaagaaga acactttaat   2460

tgaaagcaac actaatatag agccacttcc tgaaaccaag aatctgtagt tttgatccaa   2520

aatctaaaac ttaaagtcag aaaataatta aaatttttct tgtagaaatt ttagatattt   2580

tctagtattc tttagatgct cacattgttt taaataaaat agatgaaatg ggaagtttag   2640

gtaatcatct agacagatga aattattatc taggtaggag ggcttttcta tacattttct   2700

gagggaaagc agaacaccgg ggttatagct ataccttcag gtcttttgtt acttaggcaa   2760

ggaaaaccac atgtctgacc tggttcagca tgtaatccga gcactttggg aggctgaggc   2820

aggcggatca cttgaggtca gcagtttgag acgagcctgg ccaacatggt gaaaccctgt   2880

agctactgaa aatacaaaaa taagccaggc gtggtggcgg gaggctgagg caaggagaat   2940

cacttgaata caagaggcag aggttgcagt gagccaagtt cccccactgt actccagcct   3000

gggtgacaga gtaagactcc atctcaaaac aac                                3033


<210>  908
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  908

Met Lys Pro Ser Trp Leu Gln Cys Arg Lys Val Thr Ser Ala Gly Gly 
1               5                   10                  15


Leu Gly Gly Pro Leu Pro Gly Ser Ser Pro Ala Arg Gly Ala Gly Ala 
            20                  25                  30


Ala Leu Arg Ala Leu Val Val Pro Gly Pro Arg Gly Gly Leu Gly Gly 
        35                  40                  45


Arg Gly Cys Arg Ala Leu Ser Ser Gly Ser Gly Ser Glu Tyr Lys Thr 
    50                  55                  60


His Phe Ala Ala Ser Val Thr Asp Pro Glu Arg Phe Trp Gly Lys Ala 
65                  70                  75                  80


Ala Glu Gln Ile Ser Trp Tyr Lys Pro Trp Thr Lys Thr Leu Glu Asn 
                85                  90                  95


Lys His Ser Pro Ser Thr Arg Trp Phe Val Glu Gly Met Leu Asn Ile 
            100                 105                 110


Cys Tyr Asn Ala Val Asp Arg His Ile Glu Asn Gly Lys Gly Asp Lys 
        115                 120                 125


Ile Ala Ile Ile Tyr Asp Ser Pro Val Thr Asn Thr Lys Ala Thr Phe 
    130                 135                 140


Thr Tyr Lys Glu Val Leu Glu Gln Val Ser Lys Leu Ala Gly Val Leu 
145                 150                 155                 160


Val Lys His Gly Ile Lys Lys Gly Asp Thr Val Val Ile Tyr Met Pro 
                165                 170                 175


Met Ile Pro Gln Ala Met Tyr Thr Met Leu Ala Cys Ala Arg Ile Gly 
            180                 185                 190


Ala Ile His Ser Leu Ile Phe Gly Gly Phe Ala Ser Lys Glu Leu Ser 
        195                 200                 205


Ser Arg Ile Asp His Val Lys Pro Lys Val Val Val Thr Ala Ser Phe 
    210                 215                 220


Gly Ile Glu Pro Gly Arg Arg Val Glu Tyr Val Pro Leu Val Glu Glu 
225                 230                 235                 240


Ala Leu Lys Ile Gly Gln His Lys Pro Asp Lys Ile Leu Ile Tyr Asn 
                245                 250                 255


Arg Pro Asn Met Glu Ala Val Pro Leu Ala Pro Gly Arg Asp Leu Asp 
            260                 265                 270


Trp Asp Glu Glu Met Ala Lys Ala Gln Ser His Asp Cys Val Pro Val 
        275                 280                 285


Leu Ser Glu His Pro Leu Tyr Ile Leu Tyr Thr Ser Gly Thr Thr Gly 
    290                 295                 300


Leu Pro Lys Gly Val Ile Arg Pro Thr Gly Gly Tyr Ala Val Met Leu 
305                 310                 315                 320


His Trp Ser Met Ser Ser Ile Tyr Gly Leu Gln Pro Gly Glu Val Trp 
                325                 330                 335


Trp Ala Ala Ser Asp Leu Gly Trp Val Val Gly His Ser Tyr Ile Cys 
            340                 345                 350


Tyr Gly Pro Leu Leu His Gly Asn Thr Thr Val Leu Tyr Glu Gly Lys 
        355                 360                 365


Pro Val Gly Thr Pro Asp Ala Gly Ala Tyr Phe Arg Val Leu Ala Glu 
    370                 375                 380


His Gly Val Ala Ala Leu Phe Thr Ala Pro Thr Ala Ile Arg Ala Ile 
385                 390                 395                 400


Arg Gln Gln Asp Pro Gly Ala Ala Leu Gly Lys Gln Tyr Ser Leu Thr 
                405                 410                 415


Arg Phe Lys Thr Leu Phe Val Ala Gly Glu Arg Cys Asp Val Glu Thr 
            420                 425                 430


Leu Glu Trp Ser Lys Asn Val Phe Arg Val Pro Val Leu Asp His Trp 
        435                 440                 445


Trp Gln Thr Glu Thr Gly Ser Pro Ile Thr Ala Ser Cys Val Gly Leu 
    450                 455                 460


Gly Asn Ser Lys Thr Pro Pro Pro Gly Gln Ala Gly Lys Ser Val Pro 
465                 470                 475                 480


Gly Tyr Asn Val Met Ile Leu Asp Asp Asn Met Gln Lys Leu Lys Ala 
                485                 490                 495


Arg Cys Leu Gly Asn Ile Val Val Lys Leu Pro Leu Pro Pro Gly Ala 
            500                 505                 510


Phe Ser Gly Leu Trp Lys Asn Gln Glu Ala Phe Lys His Leu Tyr Phe 
        515                 520                 525


Glu Lys Phe Pro Gly Tyr Tyr Asp Thr Met Asp Ala Gly Tyr Met Asp 
    530                 535                 540


Glu Glu Gly Tyr Leu Tyr Val Met Ser Arg Val Asp Asp Val Ile Asn 
545                 550                 555                 560


Val Ala Gly His Arg Ile Ser Ala Gly Ala Ile Glu Glu Ser Ile Leu 
                565                 570                 575


Ser His Gly Thr Val Ala Asp Cys Ala Val Val Gly Lys Glu Asp Pro 
            580                 585                 590


Leu Lys Gly His Val Pro Leu Ala Leu Cys Val Leu Arg Lys Asp Ile 
        595                 600                 605


Asn Ala Thr Glu Glu Gln Val Leu Glu Glu Ile Val Lys His Val Arg 
    610                 615                 620


Gln Asn Ile Gly Pro Val Ala Ala Phe Arg Asn Ala Val Phe Val Lys 
625                 630                 635                 640


Gln Leu Pro Lys Thr Arg Ser Gly Lys Ile Pro Arg Ser Ala Leu Ser 
                645                 650                 655


Ala Ile Val Asn Gly Lys Pro Tyr Lys Ile Thr Ser Thr Ile Glu Asp 
            660                 665                 670


Pro Ser Ile Phe Gly His Val Glu Glu Met Leu Lys Gln Ala 
        675                 680                 685


<210>  909
<211>  4457
<212>  DNA
<213>  Homo sapiens

<400>  909
tgtgattggc tgttgccatg gatacgcttt gtgtagcggc tatgggcgct gtcttacaac     60

aaagccaagg aatctcgctg ctgagggttc tgtgctttat tatgaagaat aatggacgat    120

gatgatgcaa agctcaaagc agaaatagaa gctgaattgg ataaactcag catttcctcc    180

ttggaaaaag aagacattga gagtgatgca aaatcagaaa cccagagtga tgatagtgat    240

acagattcag ttgaattacc agaatcagtt cttcactgta ttaacatcat aaagaacagg    300

agtaaagctg ttgaagagct cattcttcag gacctggaag atactgatat tttaagctgt    360

agttatggag cagtttctaa taatcatatg catttaagaa caggactatc aactgaatat    420

gaagaaagtt cagagcaatt aattaagata ttatctgaaa tagaaaaaga agaatttatg    480

agaagtaaaa ccgattgtgc cactcctgat tttgttcctg agcctagtcc tcatgacttg    540

cctatggatg aacatgtttt accagatgat gctgatataa attttggata ctgtgaagtg    600

gaagaaaaat gtagacagtc ttttgaggct tggcaagaga aacagaagga attagaagat    660

aaagagaaac aaactctcaa agctcagagg gatagagaag aaaaacaatt tcaagaagaa    720

gaagaaaagc gacattgctg gatgaaacaa tttaaagttg aaaagaagaa attagagaac    780

attcagaagc aagaacagga caagatgaat gatgaactct ataaagaaga gaaaatttgg    840

aaagagaaat ttaaacagca tgaggagtat attagaaact tgcatttaca aatggaagaa    900

gaaagaacaa gatttaaaga ccaacaagaa aaagaaaaaa attctttgtt aaaacagcag    960

aataatgcag ctgttaaaat tcaagctaaa tataaagcat ttgttgccta tcaaaaatat   1020

ggcccaatta ttaaagagca aattgaaagt aagaaaagga aagcacaaga gtggaaggaa   1080

aaggaagcaa aaatacgaca aaaggaggaa gaaaatcgaa aaagattaga ggaggaacaa   1140

aggataaaag aagagagaaa aaagcaaaag gaagaggaaa ggaaaaggag agaaaaagaa   1200

tatgaagaaa aaaagaatat tgtgaaacag gaaagagagc aactaataag caaggaaaaa   1260

ataatattaa gagaagatgc aagccaacag ctaataataa gtagtgcatt aaagaagagc   1320

ggatataata acaaacattt aagtcttgaa gatatttcaa atgataaggg tgatatagcc   1380

aaaaatctag tggatgaaaa ttcaaagaag caggaagatg ttctcctttg gctagttgag   1440

gaatcaaata tgaaagaaaa tgtagataga cagactatat taaaagaatc aatacaagta   1500

aagttaaaag aatctatatc aagccaaaca attctggcag attttaaaat ggaagaaaaa   1560

aatgaaaacc tagcaaaaaa acgatgttca gaagaattgg tcaagcaaga aagaaaatat   1620

gaaaatacag ataacaaaac tgaattggga aactctgatc taaaaggaaa tctgaaagaa   1680

cagtttccat tgcaagaatt aaagtctgat gcacaaaaag aagaaaaaat catgaaacat   1740

gtcataaatg agaatacagg acaaaaaacc cagataatat taggacataa ccaagaaatc   1800

agtgaggtga aaaccaatga agagcagaaa ataatcaaag ataatcagca gaaaaagata   1860

caaaaagtag aaaaagaaga gatacaagaa cagaatggat tattatataa agataaggat   1920

actttagtta tttcagtgaa acaaagatca ctctcactaa catcagaaaa ttccaaagat   1980

gtaagagaaa acgtaatatt acaagaaaaa gaaatttatt caaaatccaa agaaattgag   2040

gagaacccaa aagacaatgc ttggaatagt ggcattgtga tttttaacac aactgatacc   2100

atgataaata tagaaggcaa aagaaatgac caagattatg tgttaggtag acatgctcct   2160

tgtgagggct tgagtaacta taatgcagaa agctccatgg tatctaaaga agtcaactct   2220

cttaaatctg agattagaaa tatttcagaa aaatgccatg aaaatgcacc tgaacctgat   2280

agcatgacct gctgtgtatc agagtcaacc cttctatatt ctattgaaga aaggagacta   2340

gcctggataa aatcatttaa accttggctt gaaattttca agcaaaatca acaaaagaaa   2400

attgttagaa gaaagagacc tgtgaaatgc ccagccaaca tgacacccgc tttggataaa   2460

ctggaaattc ttcgatgtgg cccttgggat actttacagc aggttacaac agttacattt   2520

caagatttgc caggctgtgt tctctccaca ctggcagagt gtacaaatct tcagtttcta   2580

tcccttcgac gctgtggatt aacttctttg cacagcctga gtaattgtaa aaaacttaag   2640

tacattgatg cacaggaaaa ccatattgag gctattgagt gtgaaaattt ggaaaatctc   2700

tgtgttgttc ttcttaataa aaatcaactg acttctcttc atggtttgga tggctgtact   2760

aatattcagt gtcttgaact ttcatataat aaaattactc gaattggata ttccttcttt   2820

ctggaagaaa aacttgttga caatgcaggg ttctgccatc acttgggcac ctccacttct   2880

tacttatccc tggcacaagt ctggattcca actggattat gttggtcctg gatacctatt   2940

acctcactta caaaaaattc agattgtaat ttccttatct cccacttata ctggaattgt   3000

ggtttagaat ctttgaaaaa tcttcaacaa ctaattttgg accacaatca gttaattaat   3060

acaaaaggtc tttgtgatac acctaccatt gtatacctag attgctccca taatcatctt   3120

actgatgtag agggcgttga aaattgtgga ttgctccaaa tattgaagtt acagggaaat   3180

tatctgagtg agcttccatc cttggagaat cttgttttac taagagaatt gcacttggat   3240

gataacagca tttcaactgt ggaagcattt tcttcatact ggctgccttt actacaaaat   3300

attactatct ctcaaaacag cttgactaaa atcgtaccac tttttcattt tgtttcattg   3360

gaaaagctag atgtcagcca caattgtctt tctgatctta aaagtgccat aaaatggttt   3420

gatgcatgct attctctcca tgaattgtct cttactggaa acccacttct tcaagaaaca   3480

aactggaggg attctctact taaagtgttg cctgctctga gaatcctcaa tggcaatata   3540

ctaaactcta attcagaaag ccgcactgaa gaacacaatc aactgggatc agcaggtttc   3600

ctggcacttt gtcagtctca gattcgagaa ttcaacttgc taattgaaaa ttatataact   3660

ggaaaaggag atgtatttac cttggatact gcagaaaatc tctgtcatta ttttaagaaa   3720

ttgatgatac ttagtactga ataccgacat gcacacgaac gaggggatgt aactatcacc   3780

aagaaagatg aatcagaagc ccagaaaaat catttggccc ctacaaacag tgacagcact   3840

ctgcaaaatg gagtcttcta ctcttgtgca cgtgaaggtg agccagactc accagatatt   3900

cctgagaaat ggatggactc tgtctccagc cactccccat taagcaaatc cgccacatgt   3960

gaaaatatgg aaggaagaca tcaggaaata ttagtatgtc agaagagaga agacagcaag   4020

gcaagcagta ttcccaccat aagaatccca tttaaggaag tagtaatgac aaattctttg   4080

ctgaggaatc accaaaatat tgagcctagt gaaaaaatgt aagatatata aataatgttt   4140

cttttataga tgtatgttta ctccttttga tggatgatat tagtcaatgg tacctagtaa   4200

tttgctgaag gattcaaatc acaatcatat ttcataccga ttccattatg ttttcgtgag   4260

gtgcattatg ttttcatgag gtgcacaaat cattaattat agtgcatatt aatttgatta   4320

aattctcatt taatttctag tagtatttaa atgagtaaat gtgagttttt ttctgccttg   4380

taatttctaa ataattaata tgttttaagg agaaataaaa tatcacagtc taaaaataat   4440

aaaaacattt tctgagt                                                  4457


<210>  910
<211>  1336
<212>  PRT
<213>  Homo sapiens

<400>  910

Met Asp Asp Asp Asp Ala Lys Leu Lys Ala Glu Ile Glu Ala Glu Leu 
1               5                   10                  15


Asp Lys Leu Ser Ile Ser Ser Leu Glu Lys Glu Asp Ile Glu Ser Asp 
            20                  25                  30


Ala Lys Ser Glu Thr Gln Ser Asp Asp Ser Asp Thr Asp Ser Val Glu 
        35                  40                  45


Leu Pro Glu Ser Val Leu His Cys Ile Asn Ile Ile Lys Asn Arg Ser 
    50                  55                  60


Lys Ala Val Glu Glu Leu Ile Leu Gln Asp Leu Glu Asp Thr Asp Ile 
65                  70                  75                  80


Leu Ser Cys Ser Tyr Gly Ala Val Ser Asn Asn His Met His Leu Arg 
                85                  90                  95


Thr Gly Leu Ser Thr Glu Tyr Glu Glu Ser Ser Glu Gln Leu Ile Lys 
            100                 105                 110


Ile Leu Ser Glu Ile Glu Lys Glu Glu Phe Met Arg Ser Lys Thr Asp 
        115                 120                 125


Cys Ala Thr Pro Asp Phe Val Pro Glu Pro Ser Pro His Asp Leu Pro 
    130                 135                 140


Met Asp Glu His Val Leu Pro Asp Asp Ala Asp Ile Asn Phe Gly Tyr 
145                 150                 155                 160


Cys Glu Val Glu Glu Lys Cys Arg Gln Ser Phe Glu Ala Trp Gln Glu 
                165                 170                 175


Lys Gln Lys Glu Leu Glu Asp Lys Glu Lys Gln Thr Leu Lys Ala Gln 
            180                 185                 190


Arg Asp Arg Glu Glu Lys Gln Phe Gln Glu Glu Glu Glu Lys Arg His 
        195                 200                 205


Cys Trp Met Lys Gln Phe Lys Val Glu Lys Lys Lys Leu Glu Asn Ile 
    210                 215                 220


Gln Lys Gln Glu Gln Asp Lys Met Asn Asp Glu Leu Tyr Lys Glu Glu 
225                 230                 235                 240


Lys Ile Trp Lys Glu Lys Phe Lys Gln His Glu Glu Tyr Ile Arg Asn 
                245                 250                 255


Leu His Leu Gln Met Glu Glu Glu Arg Thr Arg Phe Lys Asp Gln Gln 
            260                 265                 270


Glu Lys Glu Lys Asn Ser Leu Leu Lys Gln Gln Asn Asn Ala Ala Val 
        275                 280                 285


Lys Ile Gln Ala Lys Tyr Lys Ala Phe Val Ala Tyr Gln Lys Tyr Gly 
    290                 295                 300


Pro Ile Ile Lys Glu Gln Ile Glu Ser Lys Lys Arg Lys Ala Gln Glu 
305                 310                 315                 320


Trp Lys Glu Lys Glu Ala Lys Ile Arg Gln Lys Glu Glu Glu Asn Arg 
                325                 330                 335


Lys Arg Leu Glu Glu Glu Gln Arg Ile Lys Glu Glu Arg Lys Lys Gln 
            340                 345                 350


Lys Glu Glu Glu Arg Lys Arg Arg Glu Lys Glu Tyr Glu Glu Lys Lys 
        355                 360                 365


Asn Ile Val Lys Gln Glu Arg Glu Gln Leu Ile Ser Lys Glu Lys Ile 
    370                 375                 380


Ile Leu Arg Glu Asp Ala Ser Gln Gln Leu Ile Ile Ser Ser Ala Leu 
385                 390                 395                 400


Lys Lys Ser Gly Tyr Asn Asn Lys His Leu Ser Leu Glu Asp Ile Ser 
                405                 410                 415


Asn Asp Lys Gly Asp Ile Ala Lys Asn Leu Val Asp Glu Asn Ser Lys 
            420                 425                 430


Lys Gln Glu Asp Val Leu Leu Trp Leu Val Glu Glu Ser Asn Met Lys 
        435                 440                 445


Glu Asn Val Asp Arg Gln Thr Ile Leu Lys Glu Ser Ile Gln Val Lys 
    450                 455                 460


Leu Lys Glu Ser Ile Ser Ser Gln Thr Ile Leu Ala Asp Phe Lys Met 
465                 470                 475                 480


Glu Glu Lys Asn Glu Asn Leu Ala Lys Lys Arg Cys Ser Glu Glu Leu 
                485                 490                 495


Val Lys Gln Glu Arg Lys Tyr Glu Asn Thr Asp Asn Lys Thr Glu Leu 
            500                 505                 510


Gly Asn Ser Asp Leu Lys Gly Asn Leu Lys Glu Gln Phe Pro Leu Gln 
        515                 520                 525


Glu Leu Lys Ser Asp Ala Gln Lys Glu Glu Lys Ile Met Lys His Val 
    530                 535                 540


Ile Asn Glu Asn Thr Gly Gln Lys Thr Gln Ile Ile Leu Gly His Asn 
545                 550                 555                 560


Gln Glu Ile Ser Glu Val Lys Thr Asn Glu Glu Gln Lys Ile Ile Lys 
                565                 570                 575


Asp Asn Gln Gln Lys Lys Ile Gln Lys Val Glu Lys Glu Glu Ile Gln 
            580                 585                 590


Glu Gln Asn Gly Leu Leu Tyr Lys Asp Lys Asp Thr Leu Val Ile Ser 
        595                 600                 605


Val Lys Gln Arg Ser Leu Ser Leu Thr Ser Glu Asn Ser Lys Asp Val 
    610                 615                 620


Arg Glu Asn Val Ile Leu Gln Glu Lys Glu Ile Tyr Ser Lys Ser Lys 
625                 630                 635                 640


Glu Ile Glu Glu Asn Pro Lys Asp Asn Ala Trp Asn Ser Gly Ile Val 
                645                 650                 655


Ile Phe Asn Thr Thr Asp Thr Met Ile Asn Ile Glu Gly Lys Arg Asn 
            660                 665                 670


Asp Gln Asp Tyr Val Leu Gly Arg His Ala Pro Cys Glu Gly Leu Ser 
        675                 680                 685


Asn Tyr Asn Ala Glu Ser Ser Met Val Ser Lys Glu Val Asn Ser Leu 
    690                 695                 700


Lys Ser Glu Ile Arg Asn Ile Ser Glu Lys Cys His Glu Asn Ala Pro 
705                 710                 715                 720


Glu Pro Asp Ser Met Thr Cys Cys Val Ser Glu Ser Thr Leu Leu Tyr 
                725                 730                 735


Ser Ile Glu Glu Arg Arg Leu Ala Trp Ile Lys Ser Phe Lys Pro Trp 
            740                 745                 750


Leu Glu Ile Phe Lys Gln Asn Gln Gln Lys Lys Ile Val Arg Arg Lys 
        755                 760                 765


Arg Pro Val Lys Cys Pro Ala Asn Met Thr Pro Ala Leu Asp Lys Leu 
    770                 775                 780


Glu Ile Leu Arg Cys Gly Pro Trp Asp Thr Leu Gln Gln Val Thr Thr 
785                 790                 795                 800


Val Thr Phe Gln Asp Leu Pro Gly Cys Val Leu Ser Thr Leu Ala Glu 
                805                 810                 815


Cys Thr Asn Leu Gln Phe Leu Ser Leu Arg Arg Cys Gly Leu Thr Ser 
            820                 825                 830


Leu His Ser Leu Ser Asn Cys Lys Lys Leu Lys Tyr Ile Asp Ala Gln 
        835                 840                 845


Glu Asn His Ile Glu Ala Ile Glu Cys Glu Asn Leu Glu Asn Leu Cys 
    850                 855                 860


Val Val Leu Leu Asn Lys Asn Gln Leu Thr Ser Leu His Gly Leu Asp 
865                 870                 875                 880


Gly Cys Thr Asn Ile Gln Cys Leu Glu Leu Ser Tyr Asn Lys Ile Thr 
                885                 890                 895


Arg Ile Gly Tyr Ser Phe Phe Leu Glu Glu Lys Leu Val Asp Asn Ala 
            900                 905                 910


Gly Phe Cys His His Leu Gly Thr Ser Thr Ser Tyr Leu Ser Leu Ala 
        915                 920                 925


Gln Val Trp Ile Pro Thr Gly Leu Cys Trp Ser Trp Ile Pro Ile Thr 
    930                 935                 940


Ser Leu Thr Lys Asn Ser Asp Cys Asn Phe Leu Ile Ser His Leu Tyr 
945                 950                 955                 960


Trp Asn Cys Gly Leu Glu Ser Leu Lys Asn Leu Gln Gln Leu Ile Leu 
                965                 970                 975


Asp His Asn Gln Leu Ile Asn Thr Lys Gly Leu Cys Asp Thr Pro Thr 
            980                 985                 990


Ile Val Tyr Leu Asp Cys Ser His Asn His Leu Thr Asp Val Glu Gly 
        995                 1000                1005


Val Glu Asn Cys Gly Leu Leu Gln Ile Leu Lys Leu Gln Gly Asn Tyr 
    1010                1015                1020


Leu Ser Glu Leu Pro Ser Leu Glu Asn Leu Val Leu Leu Arg Glu Leu 
1025                1030                1035                1040


His Leu Asp Asp Asn Ser Ile Ser Thr Val Glu Ala Phe Ser Ser Tyr 
                1045                1050                1055


Trp Leu Pro Leu Leu Gln Asn Ile Thr Ile Ser Gln Asn Ser Leu Thr 
            1060                1065                1070


Lys Ile Val Pro Leu Phe His Phe Val Ser Leu Glu Lys Leu Asp Val 
        1075                1080                1085


Ser His Asn Cys Leu Ser Asp Leu Lys Ser Ala Ile Lys Trp Phe Asp 
    1090                1095                1100


Ala Cys Tyr Ser Leu His Glu Leu Ser Leu Thr Gly Asn Pro Leu Leu 
1105                1110                1115                1120


Gln Glu Thr Asn Trp Arg Asp Ser Leu Leu Lys Val Leu Pro Ala Leu 
                1125                1130                1135


Arg Ile Leu Asn Gly Asn Ile Leu Asn Ser Asn Ser Glu Ser Arg Thr 
            1140                1145                1150


Glu Glu His Asn Gln Leu Gly Ser Ala Gly Phe Leu Ala Leu Cys Gln 
        1155                1160                1165


Ser Gln Ile Arg Glu Phe Asn Leu Leu Ile Glu Asn Tyr Ile Thr Gly 
    1170                1175                1180


Lys Gly Asp Val Phe Thr Leu Asp Thr Ala Glu Asn Leu Cys His Tyr 
1185                1190                1195                1200


Phe Lys Lys Leu Met Ile Leu Ser Thr Glu Tyr Arg His Ala His Glu 
                1205                1210                1215


Arg Gly Asp Val Thr Ile Thr Lys Lys Asp Glu Ser Glu Ala Gln Lys 
            1220                1225                1230


Asn His Leu Ala Pro Thr Asn Ser Asp Ser Thr Leu Gln Asn Gly Val 
        1235                1240                1245


Phe Tyr Ser Cys Ala Arg Glu Gly Glu Pro Asp Ser Pro Asp Ile Pro 
    1250                1255                1260


Glu Lys Trp Met Asp Ser Val Ser Ser His Ser Pro Leu Ser Lys Ser 
1265                1270                1275                1280


Ala Thr Cys Glu Asn Met Glu Gly Arg His Gln Glu Ile Leu Val Cys 
                1285                1290                1295


Gln Lys Arg Glu Asp Ser Lys Ala Ser Ser Ile Pro Thr Ile Arg Ile 
            1300                1305                1310


Pro Phe Lys Glu Val Val Met Thr Asn Ser Leu Leu Arg Asn His Gln 
        1315                1320                1325


Asn Ile Glu Pro Ser Glu Lys Met 
    1330                1335


<210>  911
<211>  1320
<212>  DNA
<213>  Homo sapiens

<400>  911
gattatggag tttctgagcg agaagtttgc cctcaagagc cctccgagta aaaacagtga     60

cttttacatg ggcgcaggag gtcctctgga gcacgttatg gagacgctgg acaatgagtc    120

cttttacagc aaagcgtctg caggcaaatg cgtgcaggcc ttcggacccc tgccccgcgc    180

cgagcatcac gtgcgcttgg agaggacctc gccctgtcag gacagcagcg tgaactatgg    240

gatcactaaa gtagaaggac agccccttca caccgaactg aatagagcta tggacaactg    300

taacagtctc cgaatgtctc ccgtgaaagg gatgcaagag aagggagagc tggatgaact    360

tggggataaa tgtgatagca atgtatccag cagtaagaaa cggaggcacc gaaccacctt    420

caccagtttg cagctagagg agctggagaa agtctttcag aaaactcatt acccggatgt    480

gtatgtcaga gaacagcttg ctctgaggac agagctcact gaggccaggg tccaggtttg    540

gtttcaaaat cgaagggcca aatggagaaa aagggaacgt tatggccaaa tacaacaagc    600

gaaaagccat tttgctgcca cctatgatat atcagttttg ccaaggactg acagctaccc    660

acagattcag aacaatttgt gggcaggaaa tgcaagtggt ggttctgtgg ttacttcatg    720

catgttacca cgtgacactt cctcctgtat gacaccttat tctcactcgc ctcggacaga    780

ttccagttac acggggtttt caaaccacca gaaccagttc agccacgtgc ccctcaacaa    840

ttttttcact gactctcttc ttactggggc aaccaatgga catgcatttg aaacaaagcc    900

agagtttgaa aggaggtctt ccagtatcgc agttcttcga atgaaagcca aggagcacac    960

cgccaatatt tcatgggcca tgtaacatac agtactcttt tatttttctt ttaatagcaa   1020

agttaaacat tcttatttct catatttaaa ggataccaca ataagctgct gtgtgtggaa   1080

ttgctaaagg tcaagatatt cagtgagacc agcttaaatg aatagttgtt atttaacatt   1140

aaaatctaag aatgaacctc tgaaaagact aaataggttt accatgtgcc agtctccaca   1200

aaccctgttt tagtagtaag gttttctttt tctattgtac aagtcaatga aatatgatca   1260

cgcaacttat taaagaataa atgtgttaaa caaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1320


<210>  912
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  912

Met Glu Phe Leu Ser Glu Lys Phe Ala Leu Lys Ser Pro Pro Ser Lys 
1               5                   10                  15


Asn Ser Asp Phe Tyr Met Gly Ala Gly Gly Pro Leu Glu His Val Met 
            20                  25                  30


Glu Thr Leu Asp Asn Glu Ser Phe Tyr Ser Lys Ala Ser Ala Gly Lys 
        35                  40                  45


Cys Val Gln Ala Phe Gly Pro Leu Pro Arg Ala Glu His His Val Arg 
    50                  55                  60


Leu Glu Arg Thr Ser Pro Cys Gln Asp Ser Ser Val Asn Tyr Gly Ile 
65                  70                  75                  80


Thr Lys Val Glu Gly Gln Pro Leu His Thr Glu Leu Asn Arg Ala Met 
                85                  90                  95


Asp Asn Cys Asn Ser Leu Arg Met Ser Pro Val Lys Gly Met Gln Glu 
            100                 105                 110


Lys Gly Glu Leu Asp Glu Leu Gly Asp Lys Cys Asp Ser Asn Val Ser 
        115                 120                 125


Ser Ser Lys Lys Arg Arg His Arg Thr Thr Phe Thr Ser Leu Gln Leu 
    130                 135                 140


Glu Glu Leu Glu Lys Val Phe Gln Lys Thr His Tyr Pro Asp Val Tyr 
145                 150                 155                 160


Val Arg Glu Gln Leu Ala Leu Arg Thr Glu Leu Thr Glu Ala Arg Val 
                165                 170                 175


Gln Val Trp Phe Gln Asn Arg Arg Ala Lys Trp Arg Lys Arg Glu Arg 
            180                 185                 190


Tyr Gly Gln Ile Gln Gln Ala Lys Ser His Phe Ala Ala Thr Tyr Asp 
        195                 200                 205


Ile Ser Val Leu Pro Arg Thr Asp Ser Tyr Pro Gln Ile Gln Asn Asn 
    210                 215                 220


Leu Trp Ala Gly Asn Ala Ser Gly Gly Ser Val Val Thr Ser Cys Met 
225                 230                 235                 240


Leu Pro Arg Asp Thr Ser Ser Cys Met Thr Pro Tyr Ser His Ser Pro 
                245                 250                 255


Arg Thr Asp Ser Ser Tyr Thr Gly Phe Ser Asn His Gln Asn Gln Phe 
            260                 265                 270


Ser His Val Pro Leu Asn Asn Phe Phe Thr Asp Ser Leu Leu Thr Gly 
        275                 280                 285


Ala Thr Asn Gly His Ala Phe Glu Thr Lys Pro Glu Phe Glu Arg Arg 
    290                 295                 300


Ser Ser Ser Ile Ala Val Leu Arg Met Lys Ala Lys Glu His Thr Ala 
305                 310                 315                 320


Asn Ile Ser Trp Ala Met 
                325


<210>  913
<211>  545
<212>  DNA
<213>  Homo sapiens

<400>  913
atgctagtgg aaaacagttt gatctcagac tgctgtgcta gcaatcagcg agactccgtg     60

ggcgtaggac cctccgagcc aggcatcagc tatcaaaact tatgggaaat ggaattgaag    120

acaactactt ctagaattgg tgcatggaag cttctcatag gtgattagcc acactcttct    180

tctgtcaacc tggtgcagaa aagcttgaag accttggaaa tcacatattg atgatggagg    240

agatacaaga atgaaggacc ctgggttcct gaatcaacac tctaagaaga gactccttga    300

aatcaagagc actcattttg acattgcaaa cggaaaaatt cacttctatc aggtttgaac    360

caatatatag tttagggttt ttaaaaaata actgttagca tgactttaac taatacacat    420

gccatacagg atcagacctc tgtgactttg cttttacagt ctgctctgtc tggaggggag    480

tttcatcttt gccatcctta atgatatagc atagacgcta tgtcctccag aaacttcctt    540

ggcac                                                                545


<210>  914
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  914

Met Leu Val Glu Asn Ser Leu Ile Ser Asp Cys Cys Ala Ser Asn Gln 
1               5                   10                  15


Arg Asp Ser Val Gly Val Gly Pro Ser Glu Pro Gly Ile Ser Tyr Gln 
            20                  25                  30


Asn Leu Trp Glu Met Glu Leu Lys Thr Thr Thr Ser Arg Ile Gly Ala 
        35                  40                  45


Trp Lys Leu Leu Ile Gly Asp 
    50                  55


<210>  915
<211>  2958
<212>  DNA
<213>  Homo sapiens

<400>  915
aaattgcgga acgcgagggg cgagcgcgag ggagcccccc tccggaaccc ctgcccaccc     60

ccggagcgcc ggcagcggcg gccccgcgag gatcggctcc aggagatgat agaaagtgac    120

acctcatcca taatgtcagg aattattcga aactcagggc aaaatcacca cccctctcca    180

caggaataca gggtcaagca gggcaggctt cctggcagag gcggcattgg gctgtcagcc    240

tgagaccctt tcatgcctgg cctgccctgt cctgccctgc cctgccctgc cccacctcct    300

gcccccagct gtctgatcgc catggccctg aagaacagca agacaggcag cctgcctgtg    360

agcgagatct acagcttcat gaaggagcac ttcccctact tcaagacggc ccccgacggg    420

tggaagaact cggtgcggca caacctgtct ctgaacaagt gcttcgagaa ggtggagaac    480

aagatgagcg gctcctcccg caagggctgc ctgtgggctc tgaacctggc ccgcatcgac    540

aagatggagg aggagatgca caagtggaag aggaaggacc tggctgccat ccaccggagt    600

atggccaacc ctgaggagtt ggacaagctg atctccgacc ggcctgaaag ctgccggcgc    660

cccggcaaac cgggggaacc agaggccccc gtgctgactc acgccaccac agtggccgtg    720

gcgcatggct gcctggctgt ctcccagctc ccaccccagc cactgatgac cctgtccctg    780

cagtcagtcc ccctgcacca ccaggtccag ccccaggcac atcttgctcc agactctcca    840

gcaccagccc agaccccgcc actgcacgcc ctgccggacc tcagccccag cccgctcccc    900

caccccgcca tgggaagggc tcctgtagac ttcatcaaca tcagcaccga catgaacact    960

gaggtggatg ccctcgaccc gagcatcatg gacttcgctc tgcaggggaa cctgtgggag   1020

gagatgaagg atgagggatt cagcctggac acactgggcg cctttgcaga ctccccgctt   1080

ggctgtgacc tgggggcctc aggcctaacc cctgcctcgg gtggcagcga ccagtccttc   1140

ccagacttgc aggtgacggg tctctacaca gcgtactcca ctccggacag tgtggctgca   1200

tcgggcacca gctcctcctc ccagtacctt ggtgcacagg ggaacaagcc tatagccctg   1260

ctttgagctg tcagcctcac ctgccctgga accccggcac ccggcttggg cagagaactg   1320

actagaacag ggtgttccca gaaggcaggt ccctcattgt ccccgaagcc tctcctggac   1380

ctgtggcgaa gttgccggct ggacagggaa gcggttcccc tcagcagccc ctctccttct   1440

cgtgcctccc cctggagctt ccggagcagt ttctgggggc tcttccaagt cagaagaatg   1500

gaggaaggtg gacaagcaac ccagcatccc ctgacccctt gacactcctc cgaggcctga   1560

gccgcaatgc ctgcccgtgt tgagtgagac ttctccatcc tggatcctgg ctgcgtgacc   1620

tcagtgacct gcaccccatt ttgggacacc ttggtgcatt aaggaaacac cctggggtga   1680

aagcccttga attcatcctc atgggaaatg gctgagtgga tcaaacctca gccgcagcct   1740

ccgggggaca ggcccagggc gggaaatgga gccggagaag cttgagcctc tctcttggac   1800

aggacaagct gaactctgaa atgggagccg gtccaggtgg ccttcagccc cacctttccg   1860

atagtctgtt agaattttat tagcgcagat tcctgggcca tgccgggtac cgtgaccttg   1920

tgtaaattta tttatattta ttgtggccca tccaccccac ttctgcaaac ccatcccgag   1980

gcctctggaa tgggactcct tctccctccc tacctcccag ccatcctaac tcctacaggc   2040

cagagaatga catctctaac tggctcataa tcccttggca gcctggggct actttttaga   2100

accagcaagc actgttgata ctgtgaaaca tcccattttt tccgtattag agaccagata   2160

tttttctacc tgttcatgat tcacatctct tcttgcatgt acctaagagg ggcggtgcca   2220

ttgtttgggg gcttgggggg ctttcaaagg ggaaaatgcg atgggagagg gaggaactgg   2280

aggggggtgc ttttgtactg ggatttaaga cacccctgat ggaatgaaag ccaactgaac   2340

cacgtaaagc tcgaaccacg tggcaagtgg tggacaaaac ttcaacgcat gatatttatt   2400

ggcacttcct tacctccctt tgccctgcag ctgtttttat gcttcttttt ctctccttgc   2460

taattactga ctccccaagt ggcaagttcc gcagatagct gggttagaag agagacaggg   2520

gagtgagcta gtcaaatgtg aaaaatgctc tcccagcaaa gctgagacaa aattggagaa   2580

gctgcagcct cacgcaccat ccccctcttt ccaccagatg gatgttgact tggtgtctgg   2640

gagttcccga accctagagc caggatgttc tgtttaatca acagctcagc cagctgcctg   2700

ggagttttgg cattaagccc cgccttgaag ggcgagcttt aagtttttcc cagttctgga   2760

actttctacc gagtatccac cacccttaga cacaatccca gtgctacccg tctgacctgc   2820

actgctcatc tgctttgtgt aacatgaccc ctgataagat gttgaaactg ttattcacaa   2880

agactccgtg tttgggcaac atcaagactg taagtgtaga attgagcaac tgtcttctat   2940

caataaaggc tgaatggc                                                 2958


<210>  916
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  916

Met Pro Gly Leu Pro Cys Pro Ala Leu Pro Cys Pro Ala Pro Pro Pro 
1               5                   10                  15


Ala Pro Ser Cys Leu Ile Ala Met Ala Leu Lys Asn Ser Lys Thr Gly 
            20                  25                  30


Ser Leu Pro Val Ser Glu Ile Tyr Ser Phe Met Lys Glu His Phe Pro 
        35                  40                  45


Tyr Phe Lys Thr Ala Pro Asp Gly Trp Lys Asn Ser Val Arg His Asn 
    50                  55                  60


Leu Ser Leu Asn Lys Cys Phe Glu Lys Val Glu Asn Lys Met Ser Gly 
65                  70                  75                  80


Ser Ser Arg Lys Gly Cys Leu Trp Ala Leu Asn Leu Ala Arg Ile Asp 
                85                  90                  95


Lys Met Glu Glu Glu Met His Lys Trp Lys Arg Lys Asp Leu Ala Ala 
            100                 105                 110


Ile His Arg Ser Met Ala Asn Pro Glu Glu Leu Asp Lys Leu Ile Ser 
        115                 120                 125


Asp Arg Pro Glu Ser Cys Arg Arg Pro Gly Lys Pro Gly Glu Pro Glu 
    130                 135                 140


Ala Pro Val Leu Thr His Ala Thr Thr Val Ala Val Ala His Gly Cys 
145                 150                 155                 160


Leu Ala Val Ser Gln Leu Pro Pro Gln Pro Leu Met Thr Leu Ser Leu 
                165                 170                 175


Gln Ser Val Pro Leu His His Gln Val Gln Pro Gln Ala His Leu Ala 
            180                 185                 190


Pro Asp Ser Pro Ala Pro Ala Gln Thr Pro Pro Leu His Ala Leu Pro 
        195                 200                 205


Asp Leu Ser Pro Ser Pro Leu Pro His Pro Ala Met Gly Arg Ala Pro 
    210                 215                 220


Val Asp Phe Ile Asn Ile Ser Thr Asp Met Asn Thr Glu Val Asp Ala 
225                 230                 235                 240


Leu Asp Pro Ser Ile Met Asp Phe Ala Leu Gln Gly Asn Leu Trp Glu 
                245                 250                 255


Glu Met Lys Asp Glu Gly Phe Ser Leu Asp Thr Leu Gly Ala Phe Ala 
            260                 265                 270


Asp Ser Pro Leu Gly Cys Asp Leu Gly Ala Ser Gly Leu Thr Pro Ala 
        275                 280                 285


Ser Gly Gly Ser Asp Gln Ser Phe Pro Asp Leu Gln Val Thr Gly Leu 
    290                 295                 300


Tyr Thr Ala Tyr Ser Thr Pro Asp Ser Val Ala Ala Ser Gly Thr Ser 
305                 310                 315                 320


Ser Ser Ser Gln Tyr Leu Gly Ala Gln Gly Asn Lys Pro Ile Ala Leu 
                325                 330                 335


Leu 



<210>  917
<211>  716
<212>  DNA
<213>  Homo sapiens

<400>  917
aaattgtgcg gttaacggtc aaagcccccc tgcctacttt gacactcatt taaagatgac     60

agggaacaat agagatttgt tctgtgcaac cctttcttgt tatgccggcg acatcagctc    120

cgcacatgaa actgcccgat atttcattcc acctgccacc tccctcccgc ctcggtcgac    180

tctctcctct gctactttgc ttgtccccac tttaacacaa agagacagct ctgtgttcac    240

agcacctaac agtgttgaaa aagaatgcta tttaaaaccc gagttgagac atcacctttc    300

caaacccatg actgcttcct ggctcactaa acacgaacca gaaattaatg ctgcaaagag    360

cagagacaag agattcgact gtgttagcca ggatggtctc gatctcctga cttcgtgatc    420

tgcccgcctc agcctcccaa agtgctggga ttacaggctt gagccactgt gcctggcttc    480

aggctgggat ttttatagct tattatggca agggaggaga cggagagtaa aagaagaagg    540

aagagcatac acagtcaccc cttgtgtgac aaatatgcaa gaaataaaga taaatgtgta    600

caattcttac aattttactt ttctgaattt tgctattgca ctgaatgatt tgtgataaga    660

cagatgggga tgaaaaatat acttattaaa taaacagcta ttaaaagccc ctaaaa        716


<210>  918
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  918

Met Thr Gly Asn Asn Arg Asp Leu Phe Cys Ala Thr Leu Ser Cys Tyr 
1               5                   10                  15


Ala Gly Asp Ile Ser Ser Ala His Glu Thr Ala Arg Tyr Phe Ile Pro 
            20                  25                  30


Pro Ala Thr Ser Leu Pro Pro Arg Ser Thr Leu Ser Ser Ala Thr Leu 
        35                  40                  45


Leu Val Pro Thr Leu Thr Gln Arg Asp Ser Ser Val Phe Thr Ala Pro 
    50                  55                  60


Asn Ser Val Glu Lys Glu Cys Tyr Leu Lys Pro Glu Leu Arg His His 
65                  70                  75                  80


Leu Ser Lys Pro Met Thr Ala Ser Trp Leu Thr Lys His Glu Pro Glu 
                85                  90                  95


Ile Asn Ala Ala Lys Ser Arg Asp Lys Arg Phe Asp Cys Val Ser Gln 
            100                 105                 110


Asp Gly Leu Asp Leu Leu Thr Ser 
        115                 120


<210>  919
<211>  2628
<212>  DNA
<213>  Homo sapiens

<400>  919
gtgcgctgcc gtaccggtca cgtggacgtt tggtcacgtg actgcgtccg tggtcctccc     60

gtaggaaccg gcggactcgg ttggcgttgt ggggcagggg gtggtggagc aagatggcgg    120

ctcatctgtc ctacggccga gtgaacctaa acgtgttgcg cgaggcggtg cgtcgcgagc    180

tgcgcgagtt cctggacaag tgcgcaggaa gcaaggcaat agtttgggat gaatacctaa    240

ctggaccctt tggcctgatt gcacagtatt cactattgaa ggaacatgaa gtggaaaaaa    300

tgttcacact taaaggaaat cgtttgccgg cagctgatgt gaagaatata attttttttg    360

tcagacccag gctagagttg atggatataa tcgctgaaaa cgtgctcagt gaagatagac    420

gaggcccaac gagagatttt catattctgt ttgtgccacg ccgtagcctg ttgtgcgaac    480

agcggttgaa ggatctgggt gtcttgggat cctttattca cagggaggag tacagcttag    540

atctcattcc attcgatggg gatctcttat ccatggaatc agagggtgca ttcaaagagt    600

gctacctgga gggtgaccag acgagcctgt accacgcagc caaggggctg atgaccctgc    660

aagctctgta tggaacgatc ccccagatct ttgggaaagg agaatgcgct cggcaagtgg    720

ccaatatgat gatcaggatg aagagagagt ttacaggaag ccagaattca atatttcctg    780

tttttgataa tctcttgttg cttgatcgga atgtggattt attaacacct cttgccactc    840

agctgacata tgaaggactc attgatgaaa tttatggcat tcagaacagt tatgtgaaat    900

tacctccaga gaaatttgca cctaagaaac agggcgatgg tggtaaggac ctccccacgg    960

aagcaaagaa gctgcagctg aattctgcag aggagctcta tgctgagatc cgagataaga   1020

acttcaacgc agttggctct gtgctcagca agaaagcaaa gatcatctct gcagcattcg   1080

aggaaagaca caatgctaag accgtggggg agatcaagca gtttgtttcc cagttgcccc   1140

acatgcaggc agcaaggggc tcgcttgcaa accatacctc aattgcagaa ttgatcaaag   1200

atgtcactac ttctgaagac ttttttgata aattaaccgt ggaacaggag tttatgtctg   1260

gaatagacac tgataaggtc aacaattaca ttgaggattg tatcgcccaa aagcactcgt   1320

tgatcaaggt gttaagacta gtttgcctcc aatccgtgtg taatagtggg ctcaaacaaa   1380

aagttttgga ttattacaaa agagagattc tccagacata cggctatgag cacatattga   1440

ccttacacaa cctggagaag gccggcctgc tgaaaccgca gacggggggc agaaacaatt   1500

acccaactat acggaaaaca ttacgcctct ggatggatga tgttaatgag caaaacccca   1560

cggacatatc gtatgtgtac agtgggtatg ccccgctcag tgtgcggctg gcccagctgc   1620

tttcccggcc tggctggcgg agcatcgagg aggtcctccg catcctccca gggccccact   1680

ttgaggagcg gcagccactg cccacaggac tgcagaagaa acgtcaaccg ggagaaaacc   1740

gagtgactct gatatttttc cttgggggcg taaccttcgc tgaaattgct gccctgcgat   1800

ttctctccca gttggaagat ggaggtacag aatatgtcat tgccaccact aaactaatga   1860

atggaaccag ttggatagag gctctgatgg aaaaaccttt ctaggatgtt cagaggagac   1920

ttaacaagtg tactgcagaa taaactacct ctttgaagaa attgctgaaa ggaagtaaaa   1980

ccccatagaa gaaacatggg aatacagaat atattctggg gtcagcttct taaattatac   2040

tactgtttac tgctttctcc gtctcttttg tattcccttt ttttttttcc tttgagacgg   2100

agtcttgctc tgtcacccag actagagtgc agtggcacgg tctcacctca ctgcaacctc   2160

cacctcctag gttcaagcaa ttctcctgcc tcagcctcct gagtagctgg gactacaggc   2220

atgcaccacc acacccggct aatttttgta tttttagtag ccatggtgtt tcaccatgtt   2280

ggccaggctg gtctcaaact cctgacctca ggtgatccac ctgcctcggc ctcccacagt   2340

gctgggatta caggcctgag ccaccgtgcc tggcccctaa tctgctgaag aaagaagaat   2400

agaagaaaat caacctgagt aaaagcagca ctggttttga gttttctaag ctcagggtct   2460

tcattagaga cctctggaaa tacattaagg atggtggggg tagataatcc attcagccag   2520

acaaacgggg ccagctctta aaataagaaa gctgagactg aggaggtgaa actgaaaata   2580

aaaagagaaa gttcatcctc taaaaaaaaa aaaaaaaaaa aaaaaaaa                2628


<210>  920
<211>  596
<212>  PRT
<213>  Homo sapiens

<400>  920

Met Ala Ala His Leu Ser Tyr Gly Arg Val Asn Leu Asn Val Leu Arg 
1               5                   10                  15


Glu Ala Val Arg Arg Glu Leu Arg Glu Phe Leu Asp Lys Cys Ala Gly 
            20                  25                  30


Ser Lys Ala Ile Val Trp Asp Glu Tyr Leu Thr Gly Pro Phe Gly Leu 
        35                  40                  45


Ile Ala Gln Tyr Ser Leu Leu Lys Glu His Glu Val Glu Lys Met Phe 
    50                  55                  60


Thr Leu Lys Gly Asn Arg Leu Pro Ala Ala Asp Val Lys Asn Ile Ile 
65                  70                  75                  80


Phe Phe Val Arg Pro Arg Leu Glu Leu Met Asp Ile Ile Ala Glu Asn 
                85                  90                  95


Val Leu Ser Glu Asp Arg Arg Gly Pro Thr Arg Asp Phe His Ile Leu 
            100                 105                 110


Phe Val Pro Arg Arg Ser Leu Leu Cys Glu Gln Arg Leu Lys Asp Leu 
        115                 120                 125


Gly Val Leu Gly Ser Phe Ile His Arg Glu Glu Tyr Ser Leu Asp Leu 
    130                 135                 140


Ile Pro Phe Asp Gly Asp Leu Leu Ser Met Glu Ser Glu Gly Ala Phe 
145                 150                 155                 160


Lys Glu Cys Tyr Leu Glu Gly Asp Gln Thr Ser Leu Tyr His Ala Ala 
                165                 170                 175


Lys Gly Leu Met Thr Leu Gln Ala Leu Tyr Gly Thr Ile Pro Gln Ile 
            180                 185                 190


Phe Gly Lys Gly Glu Cys Ala Arg Gln Val Ala Asn Met Met Ile Arg 
        195                 200                 205


Met Lys Arg Glu Phe Thr Gly Ser Gln Asn Ser Ile Phe Pro Val Phe 
    210                 215                 220


Asp Asn Leu Leu Leu Leu Asp Arg Asn Val Asp Leu Leu Thr Pro Leu 
225                 230                 235                 240


Ala Thr Gln Leu Thr Tyr Glu Gly Leu Ile Asp Glu Ile Tyr Gly Ile 
                245                 250                 255


Gln Asn Ser Tyr Val Lys Leu Pro Pro Glu Lys Phe Ala Pro Lys Lys 
            260                 265                 270


Gln Gly Asp Gly Gly Lys Asp Leu Pro Thr Glu Ala Lys Lys Leu Gln 
        275                 280                 285


Leu Asn Ser Ala Glu Glu Leu Tyr Ala Glu Ile Arg Asp Lys Asn Phe 
    290                 295                 300


Asn Ala Val Gly Ser Val Leu Ser Lys Lys Ala Lys Ile Ile Ser Ala 
305                 310                 315                 320


Ala Phe Glu Glu Arg His Asn Ala Lys Thr Val Gly Glu Ile Lys Gln 
                325                 330                 335


Phe Val Ser Gln Leu Pro His Met Gln Ala Ala Arg Gly Ser Leu Ala 
            340                 345                 350


Asn His Thr Ser Ile Ala Glu Leu Ile Lys Asp Val Thr Thr Ser Glu 
        355                 360                 365


Asp Phe Phe Asp Lys Leu Thr Val Glu Gln Glu Phe Met Ser Gly Ile 
    370                 375                 380


Asp Thr Asp Lys Val Asn Asn Tyr Ile Glu Asp Cys Ile Ala Gln Lys 
385                 390                 395                 400


His Ser Leu Ile Lys Val Leu Arg Leu Val Cys Leu Gln Ser Val Cys 
                405                 410                 415


Asn Ser Gly Leu Lys Gln Lys Val Leu Asp Tyr Tyr Lys Arg Glu Ile 
            420                 425                 430


Leu Gln Thr Tyr Gly Tyr Glu His Ile Leu Thr Leu His Asn Leu Glu 
        435                 440                 445


Lys Ala Gly Leu Leu Lys Pro Gln Thr Gly Gly Arg Asn Asn Tyr Pro 
    450                 455                 460


Thr Ile Arg Lys Thr Leu Arg Leu Trp Met Asp Asp Val Asn Glu Gln 
465                 470                 475                 480


Asn Pro Thr Asp Ile Ser Tyr Val Tyr Ser Gly Tyr Ala Pro Leu Ser 
                485                 490                 495


Val Arg Leu Ala Gln Leu Leu Ser Arg Pro Gly Trp Arg Ser Ile Glu 
            500                 505                 510


Glu Val Leu Arg Ile Leu Pro Gly Pro His Phe Glu Glu Arg Gln Pro 
        515                 520                 525


Leu Pro Thr Gly Leu Gln Lys Lys Arg Gln Pro Gly Glu Asn Arg Val 
    530                 535                 540


Thr Leu Ile Phe Phe Leu Gly Gly Val Thr Phe Ala Glu Ile Ala Ala 
545                 550                 555                 560


Leu Arg Phe Leu Ser Gln Leu Glu Asp Gly Gly Thr Glu Tyr Val Ile 
                565                 570                 575


Ala Thr Thr Lys Leu Met Asn Gly Thr Ser Trp Ile Glu Ala Leu Met 
            580                 585                 590


Glu Lys Pro Phe 
        595


<210>  921
<211>  5898
<212>  DNA
<213>  Homo sapiens

<400>  921
gctgctgctg cagtgggaca ggtggcggcg accggcggcg tccgaggaga tttaatccag     60

agactgactt cactatagaa cccacagttg tatcaatggt tggggaaaga tagtggcaac    120

aggcaaagga gaaacagctc tgacatacaa agaaaatgag tatgctaaag ccaagtgggc    180

ttaaggcccc caccaagatc ctgaagcctg gaagcacagc tctgaagaca cctacggctg    240

ttgtagctcc agtagaaaaa accatatcca gtgaaaaagc atcaagcact ccatcatctg    300

agactcagga ggaatttgtg gatgactttc gagttgggga gcgagtttgg gtgaatggaa    360

ataagcctgg atttatccag tttcttggag aaacccagtt tgcaccaggc cagtgggctg    420

gaattgtttt agatgaaccc ataggcaaga acgatggttc ggtggcagga gttcggtatt    480

tccagtgtga acctttaaag ggcatattta cccgaccttc aaagttaaca aggaaggtgc    540

aagcagaaga tgaagctaat ggcctgcaga caacgcccgc ctcccgagct acttcaccgc    600

tgtgcacttc tacggccagc atggtgtctt cctccccctc caccccttca aacatccctc    660

agaaaccatc acagccagca gcaaaggaac cttcagctac gcctccgatc agcaacctta    720

caaaaactgc cagtgaatct atctccaacc tttcagaggc tggctcaatc aagaaaggag    780

aaagagagct caaaatcgga gacagagtat tggttggtgg cactaaggct ggtgtagtcc    840

ggtttcttgg ggagaccgac tttgccaagg gggagtggtg tggcgtggag ttagatgagc    900

cacttgggaa gaatgatggc gctgttgctg gaacaaggta ttttcagtgt caacccaaat    960

atggcttgtt cgctcctgtc cacaaagtta ccaagattgg cttcccttcc actacaccag   1020

ccaaagccaa ggccaacgca gtgaggcgag tgatggcgac cacgtccgcc agcctgaagc   1080

gcagcccttc tgcctcttcc ctcagctcca tgagctcagt ggcctcctct gtgagcagca   1140

ggcccagtcg gacaggacta ttgactgaaa cctcctcccg ttacgccagg aagatctccg   1200

gtaccactgc cctccaggag gccctgaagg agaagcagca gcacattgag cagctgctgg   1260

cggaacggga tctggagagg gcggaggtgg ccaaggccac gagccacgtg ggggagatag   1320

agcaggagct agctctggcc cgggacggac atgaccagca tgtcctggaa ttggaagcca   1380

aaatggacca gctgcgaaca atggtggaag ctgctgacag ggagaaggtg gagcttctca   1440

accagcttga agaggagaaa aggaaggttg aggaccttca gttccgggtt gaagaagaat   1500

caattaccaa aggtgatctt gagacgcaga ccaaactgga gcatgcccgc attaaggagc   1560

ttgaacagag cctgctcttt gaaaagacca aagctgacaa actccagagg gagttagaag   1620

acactagggt ggctacagtt tcagaaaagt cacgtataat ggaactggag aaagacctag   1680

cattgagagt acaggaagta gctgagctcc gaagaaggct agagtccaat aagcctgctg   1740

gggatgtgga catgtcactt tcccttttgc aagagataag ctctttgcaa gaaaagttag   1800

aagtcacccg tactgaccac cagagagaaa taacttctct gaaggagcat tttggagccc   1860

gggaagaaac tcatcagaag gagataaagg ctctgtatac cgccacggaa aagctttcca   1920

aagagaacga gtcattgaaa agcaagctgg agcatgccaa caaagagaac tcagatgtga   1980

tagctctatg gaagtccaaa ctggagactg ccatcgcatc ccaccagcag gcgatggaag   2040

aactgaaggt atctttcagc aaagggcttg gaacagagac ggcagaattt gctgaactaa   2100

aaacacaaat agagaaaatg agactagatt accaacacga aatagaaaat ttgcagaatc   2160

aacaagactc tgaacgggct gcccatgcta aagagatgga agccttgagg gctaaactga   2220

tgaaagttat taaagaaaag gaaaacagtc tggaagccat caggtcgaaa ctggacaaag   2280

cagaagacca gcatctcgta gaaatggaag acacgttaaa caaattacag gaagctgaaa   2340

taaaggtaaa ggagctagag gtactgcaag ccaaatgcaa tgaacaaacc aaggttattg   2400

ataattttac atcacagctc aaggctactg aagaaaagct cttggatctt gatgcacttc   2460

ggaaagccag ttccgaaggt aaatcggaaa tgaagaaact tagacagcag cttgaggcag   2520

ctgagaaaca gattaaacat ttagagattg aaaagaatgc tgaaagtagc aaggctagta   2580

gcattaccag agagctccag gggagagagc taaagcttac taaccttcag gaaaatttga   2640

gtgaagtcag tcaagtgaaa gagactttgg aaaaagaact tcagattttg aaagaaaagt   2700

ttgctgaagc ttcagaggag gcagtctctg ttcagagaag tatgcaagaa actgtaaata   2760

agttacacca aaaggaggaa cagtttaaca tgctgtcttc tgacttggag aagctgagag   2820

aaaacttagc agatatggag gcaaaattta gagagaaaga tgagagagaa gagcagctga   2880

taaaggcaaa ggaaaaactg gaaaatgaca ttgcagaaat aatgaagatg tcaggagata   2940

actcttctca gctgacaaaa atgaacgatg aattacgtct gaaagaaaga gatgtagaag   3000

aattacagct aaaacttaca aaggctaatg aaaatgcaag ttttctgcaa aaaagtattg   3060

aggacatgac tgtcaaagct gaacagagcc agcaagaagc agctaaaaag catgaggaag   3120

aaaagaaaga attggagagg aaattgtcgg acctggaaaa gaaaatggaa acaagccaca   3180

accagtgtca ggagctgaaa gccaggtatg agagagccac ttctgagaca aaaaccaagc   3240

atgaagaaat cctacagaac ctccagaaga cgctgctgga cacagaggac aagctgaagg   3300

gcgcacggga ggagaacagt ggcttgctgc aggagctgga ggagctgaga aagcaagccg   3360

acaaagccaa agctgctcaa acagcggaag atgccatgca gataatggaa cagatgacca   3420

aagagaagac tgagactctg gcctccttgg aggacaccaa gcaaacaaat gcaaaactac   3480

agaatgaatt ggacacactt aaagaaaaca acttgaaaaa tgtggaagag ctgaacaaat   3540

caaaagaact cctgactgta gagaatcaaa aaatggaaga atttaggaaa gaaatagaaa   3600

ccctaaagca ggcagcagct cagaagtccc agcagctttc agcgttgcaa gaagagaacg   3660

ttaaacttgc tgaggagctg gggagaagca gggacgaagt cacaagtcat caaaagctgg   3720

aagaagaaag atctgtgctc aataatcagt tgttagaaat gaaaaaaaga gaatccaagt   3780

tcataaaaga cgcagatgaa gagaaagctt ccttgcagaa atccatcagt ataactagtg   3840

ccttactcac agaaaaggat gccgagctgg agaaactgag aaatgaggtc acagtgctca   3900

ggggagaaaa cgcctctgcc aagtccttgc attcagttgt tcagactcta gagtctgata   3960

aggtgaagct cgagctcaag gtaaagaact tggagcttca actcaaagaa aacaagaggc   4020

agctcagcag ctcctcaggt aatacagaca ctcaggcaga cgaggatgaa agagcccagg   4080

agagtcagat tgatttccta aattcagtaa tagtggacct tcaaaggaag aatcaagacc   4140

tcaagatgaa ggtggagatg atgtcagaag cagccctgaa tgggaacggg gatgacctaa   4200

acaattatga cagtgatgat caggagaaac agtccaagaa gaaacctcgc ctcttctgtg   4260

acatttgtga ctgctttgat ctccacgaca cagaggattg tcctacccag gcacagatgt   4320

cagaggaccc tccccattcc acacaccatg gcagtcgggg tgaggaacgc ccatactgtg   4380

aaatctgtga gatgtttgga cactgggcca ccaactgcaa tgacgacgaa accttctgat   4440

gaagcctcca gtggagaact gggcttgctc agacgcactc gcattgacac aacgtaacac   4500

cagcattgtg tgtgcagact tcaggagaac tcatgttatt ttttaacccc gtcaacaaat   4560

ctaggaaaat attttgatct tcaacaaatt gccctttagt ctccccgtat gagttagaat   4620

aataaatatt tagtaggtga gttttcacct cgaattttgt tttcttgatt tttacgtttg   4680

aagacattgc accagatgcc attacattta ttggcccccc gaccttgtag aaaaacccct   4740

accctcacaa taccttattt aagtaacttt aaattatgcc gttacttttc atatttgcac   4800

taagatattt ccaggctgca tttgtatatt tagatttttt ggttaagctt tgacactgga   4860

atgagttgaa aaaatgtgcc attttgcatt ttcatctact catttaaagt attttattct   4920

tattcaaaga aatatctgag ctctttgcac tacctgttat cagtagtgcc tttacttcag   4980

gcttgataat acttaggtgt gattataaaa tcatgaagca ggtaaaggga ggggcaagcc   5040

cccaaactgc tgtggggaca ttttataatc tatatgctgc acccacttaa tctactgtgg   5100

tgttttgttt attagttttg cataatttca gcttctatat attgtatgta tatatttttt   5160

aaaaatctat attttgggaa aaaaacatac acaatgtgtc tttctttttg gacatttacc   5220

tttttgaaaa agaaaacact taaaatgatc attaggacat aacagactag gccagacata   5280

gcatcttgtg gctttgcaac cattttcatt tgtttgtttt ccttttattt cttcaccaga   5340

tttaaataac tggaggaatt ttctccaatt tttttttcct tctctggcag gtatccccag   5400

cagtcaatta acaataagcc agtataaaac acctaaataa ccaatctaca atctcccttc   5460

acaagttttt ttactgtttt tagatgaatg tacgatgaga aattcaacgt taataattct   5520

ggattttctt atcacaaaaa agaaaatgaa ggacctcaaa gcacctgaac agtttatcga   5580

ccagtttgaa tctatttatc ttcatttgaa tgtcttctag aatatgtaaa aagtcataaa   5640

atgtatcttc catgctacat gtacaataag aacttctata attgtatata tgcctttgat   5700

gtattttccc ctcaagatta tcaactgtgt gttcgacagt gaatattcaa tctggtacca   5760

gttgaaattt ttggttataa atgtaatacg aattgtttca caaacagaaa acatgtaaag   5820

cagtattaaa atttggccaa acaagtgttc tgtatctact ttaataaatg gttattcttt   5880

aaaaaaaaaa aaaaaaaa                                                 5898


<210>  922
<211>  1427
<212>  PRT
<213>  Homo sapiens

<400>  922

Met Ser Met Leu Lys Pro Ser Gly Leu Lys Ala Pro Thr Lys Ile Leu 
1               5                   10                  15


Lys Pro Gly Ser Thr Ala Leu Lys Thr Pro Thr Ala Val Val Ala Pro 
            20                  25                  30


Val Glu Lys Thr Ile Ser Ser Glu Lys Ala Ser Ser Thr Pro Ser Ser 
        35                  40                  45


Glu Thr Gln Glu Glu Phe Val Asp Asp Phe Arg Val Gly Glu Arg Val 
    50                  55                  60


Trp Val Asn Gly Asn Lys Pro Gly Phe Ile Gln Phe Leu Gly Glu Thr 
65                  70                  75                  80


Gln Phe Ala Pro Gly Gln Trp Ala Gly Ile Val Leu Asp Glu Pro Ile 
                85                  90                  95


Gly Lys Asn Asp Gly Ser Val Ala Gly Val Arg Tyr Phe Gln Cys Glu 
            100                 105                 110


Pro Leu Lys Gly Ile Phe Thr Arg Pro Ser Lys Leu Thr Arg Lys Val 
        115                 120                 125


Gln Ala Glu Asp Glu Ala Asn Gly Leu Gln Thr Thr Pro Ala Ser Arg 
    130                 135                 140


Ala Thr Ser Pro Leu Cys Thr Ser Thr Ala Ser Met Val Ser Ser Ser 
145                 150                 155                 160


Pro Ser Thr Pro Ser Asn Ile Pro Gln Lys Pro Ser Gln Pro Ala Ala 
                165                 170                 175


Lys Glu Pro Ser Ala Thr Pro Pro Ile Ser Asn Leu Thr Lys Thr Ala 
            180                 185                 190


Ser Glu Ser Ile Ser Asn Leu Ser Glu Ala Gly Ser Ile Lys Lys Gly 
        195                 200                 205


Glu Arg Glu Leu Lys Ile Gly Asp Arg Val Leu Val Gly Gly Thr Lys 
    210                 215                 220


Ala Gly Val Val Arg Phe Leu Gly Glu Thr Asp Phe Ala Lys Gly Glu 
225                 230                 235                 240


Trp Cys Gly Val Glu Leu Asp Glu Pro Leu Gly Lys Asn Asp Gly Ala 
                245                 250                 255


Val Ala Gly Thr Arg Tyr Phe Gln Cys Gln Pro Lys Tyr Gly Leu Phe 
            260                 265                 270


Ala Pro Val His Lys Val Thr Lys Ile Gly Phe Pro Ser Thr Thr Pro 
        275                 280                 285


Ala Lys Ala Lys Ala Asn Ala Val Arg Arg Val Met Ala Thr Thr Ser 
    290                 295                 300


Ala Ser Leu Lys Arg Ser Pro Ser Ala Ser Ser Leu Ser Ser Met Ser 
305                 310                 315                 320


Ser Val Ala Ser Ser Val Ser Ser Arg Pro Ser Arg Thr Gly Leu Leu 
                325                 330                 335


Thr Glu Thr Ser Ser Arg Tyr Ala Arg Lys Ile Ser Gly Thr Thr Ala 
            340                 345                 350


Leu Gln Glu Ala Leu Lys Glu Lys Gln Gln His Ile Glu Gln Leu Leu 
        355                 360                 365


Ala Glu Arg Asp Leu Glu Arg Ala Glu Val Ala Lys Ala Thr Ser His 
    370                 375                 380


Val Gly Glu Ile Glu Gln Glu Leu Ala Leu Ala Arg Asp Gly His Asp 
385                 390                 395                 400


Gln His Val Leu Glu Leu Glu Ala Lys Met Asp Gln Leu Arg Thr Met 
                405                 410                 415


Val Glu Ala Ala Asp Arg Glu Lys Val Glu Leu Leu Asn Gln Leu Glu 
            420                 425                 430


Glu Glu Lys Arg Lys Val Glu Asp Leu Gln Phe Arg Val Glu Glu Glu 
        435                 440                 445


Ser Ile Thr Lys Gly Asp Leu Glu Thr Gln Thr Lys Leu Glu His Ala 
    450                 455                 460


Arg Ile Lys Glu Leu Glu Gln Ser Leu Leu Phe Glu Lys Thr Lys Ala 
465                 470                 475                 480


Asp Lys Leu Gln Arg Glu Leu Glu Asp Thr Arg Val Ala Thr Val Ser 
                485                 490                 495


Glu Lys Ser Arg Ile Met Glu Leu Glu Lys Asp Leu Ala Leu Arg Val 
            500                 505                 510


Gln Glu Val Ala Glu Leu Arg Arg Arg Leu Glu Ser Asn Lys Pro Ala 
        515                 520                 525


Gly Asp Val Asp Met Ser Leu Ser Leu Leu Gln Glu Ile Ser Ser Leu 
    530                 535                 540


Gln Glu Lys Leu Glu Val Thr Arg Thr Asp His Gln Arg Glu Ile Thr 
545                 550                 555                 560


Ser Leu Lys Glu His Phe Gly Ala Arg Glu Glu Thr His Gln Lys Glu 
                565                 570                 575


Ile Lys Ala Leu Tyr Thr Ala Thr Glu Lys Leu Ser Lys Glu Asn Glu 
            580                 585                 590


Ser Leu Lys Ser Lys Leu Glu His Ala Asn Lys Glu Asn Ser Asp Val 
        595                 600                 605


Ile Ala Leu Trp Lys Ser Lys Leu Glu Thr Ala Ile Ala Ser His Gln 
    610                 615                 620


Gln Ala Met Glu Glu Leu Lys Val Ser Phe Ser Lys Gly Leu Gly Thr 
625                 630                 635                 640


Glu Thr Ala Glu Phe Ala Glu Leu Lys Thr Gln Ile Glu Lys Met Arg 
                645                 650                 655


Leu Asp Tyr Gln His Glu Ile Glu Asn Leu Gln Asn Gln Gln Asp Ser 
            660                 665                 670


Glu Arg Ala Ala His Ala Lys Glu Met Glu Ala Leu Arg Ala Lys Leu 
        675                 680                 685


Met Lys Val Ile Lys Glu Lys Glu Asn Ser Leu Glu Ala Ile Arg Ser 
    690                 695                 700


Lys Leu Asp Lys Ala Glu Asp Gln His Leu Val Glu Met Glu Asp Thr 
705                 710                 715                 720


Leu Asn Lys Leu Gln Glu Ala Glu Ile Lys Val Lys Glu Leu Glu Val 
                725                 730                 735


Leu Gln Ala Lys Cys Asn Glu Gln Thr Lys Val Ile Asp Asn Phe Thr 
            740                 745                 750


Ser Gln Leu Lys Ala Thr Glu Glu Lys Leu Leu Asp Leu Asp Ala Leu 
        755                 760                 765


Arg Lys Ala Ser Ser Glu Gly Lys Ser Glu Met Lys Lys Leu Arg Gln 
    770                 775                 780


Gln Leu Glu Ala Ala Glu Lys Gln Ile Lys His Leu Glu Ile Glu Lys 
785                 790                 795                 800


Asn Ala Glu Ser Ser Lys Ala Ser Ser Ile Thr Arg Glu Leu Gln Gly 
                805                 810                 815


Arg Glu Leu Lys Leu Thr Asn Leu Gln Glu Asn Leu Ser Glu Val Ser 
            820                 825                 830


Gln Val Lys Glu Thr Leu Glu Lys Glu Leu Gln Ile Leu Lys Glu Lys 
        835                 840                 845


Phe Ala Glu Ala Ser Glu Glu Ala Val Ser Val Gln Arg Ser Met Gln 
    850                 855                 860


Glu Thr Val Asn Lys Leu His Gln Lys Glu Glu Gln Phe Asn Met Leu 
865                 870                 875                 880


Ser Ser Asp Leu Glu Lys Leu Arg Glu Asn Leu Ala Asp Met Glu Ala 
                885                 890                 895


Lys Phe Arg Glu Lys Asp Glu Arg Glu Glu Gln Leu Ile Lys Ala Lys 
            900                 905                 910


Glu Lys Leu Glu Asn Asp Ile Ala Glu Ile Met Lys Met Ser Gly Asp 
        915                 920                 925


Asn Ser Ser Gln Leu Thr Lys Met Asn Asp Glu Leu Arg Leu Lys Glu 
    930                 935                 940


Arg Asp Val Glu Glu Leu Gln Leu Lys Leu Thr Lys Ala Asn Glu Asn 
945                 950                 955                 960


Ala Ser Phe Leu Gln Lys Ser Ile Glu Asp Met Thr Val Lys Ala Glu 
                965                 970                 975


Gln Ser Gln Gln Glu Ala Ala Lys Lys His Glu Glu Glu Lys Lys Glu 
            980                 985                 990


Leu Glu Arg Lys Leu Ser Asp Leu Glu Lys Lys Met Glu Thr Ser His 
        995                 1000                1005


Asn Gln Cys Gln Glu Leu Lys Ala Arg Tyr Glu Arg Ala Thr Ser Glu 
    1010                1015                1020


Thr Lys Thr Lys His Glu Glu Ile Leu Gln Asn Leu Gln Lys Thr Leu 
1025                1030                1035                1040


Leu Asp Thr Glu Asp Lys Leu Lys Gly Ala Arg Glu Glu Asn Ser Gly 
                1045                1050                1055


Leu Leu Gln Glu Leu Glu Glu Leu Arg Lys Gln Ala Asp Lys Ala Lys 
            1060                1065                1070


Ala Ala Gln Thr Ala Glu Asp Ala Met Gln Ile Met Glu Gln Met Thr 
        1075                1080                1085


Lys Glu Lys Thr Glu Thr Leu Ala Ser Leu Glu Asp Thr Lys Gln Thr 
    1090                1095                1100


Asn Ala Lys Leu Gln Asn Glu Leu Asp Thr Leu Lys Glu Asn Asn Leu 
1105                1110                1115                1120


Lys Asn Val Glu Glu Leu Asn Lys Ser Lys Glu Leu Leu Thr Val Glu 
                1125                1130                1135


Asn Gln Lys Met Glu Glu Phe Arg Lys Glu Ile Glu Thr Leu Lys Gln 
            1140                1145                1150


Ala Ala Ala Gln Lys Ser Gln Gln Leu Ser Ala Leu Gln Glu Glu Asn 
        1155                1160                1165


Val Lys Leu Ala Glu Glu Leu Gly Arg Ser Arg Asp Glu Val Thr Ser 
    1170                1175                1180


His Gln Lys Leu Glu Glu Glu Arg Ser Val Leu Asn Asn Gln Leu Leu 
1185                1190                1195                1200


Glu Met Lys Lys Arg Glu Ser Lys Phe Ile Lys Asp Ala Asp Glu Glu 
                1205                1210                1215


Lys Ala Ser Leu Gln Lys Ser Ile Ser Ile Thr Ser Ala Leu Leu Thr 
            1220                1225                1230


Glu Lys Asp Ala Glu Leu Glu Lys Leu Arg Asn Glu Val Thr Val Leu 
        1235                1240                1245


Arg Gly Glu Asn Ala Ser Ala Lys Ser Leu His Ser Val Val Gln Thr 
    1250                1255                1260


Leu Glu Ser Asp Lys Val Lys Leu Glu Leu Lys Val Lys Asn Leu Glu 
1265                1270                1275                1280


Leu Gln Leu Lys Glu Asn Lys Arg Gln Leu Ser Ser Ser Ser Gly Asn 
                1285                1290                1295


Thr Asp Thr Gln Ala Asp Glu Asp Glu Arg Ala Gln Glu Ser Gln Ile 
            1300                1305                1310


Asp Phe Leu Asn Ser Val Ile Val Asp Leu Gln Arg Lys Asn Gln Asp 
        1315                1320                1325


Leu Lys Met Lys Val Glu Met Met Ser Glu Ala Ala Leu Asn Gly Asn 
    1330                1335                1340


Gly Asp Asp Leu Asn Asn Tyr Asp Ser Asp Asp Gln Glu Lys Gln Ser 
1345                1350                1355                1360


Lys Lys Lys Pro Arg Leu Phe Cys Asp Ile Cys Asp Cys Phe Asp Leu 
                1365                1370                1375


His Asp Thr Glu Asp Cys Pro Thr Gln Ala Gln Met Ser Glu Asp Pro 
            1380                1385                1390


Pro His Ser Thr His His Gly Ser Arg Gly Glu Glu Arg Pro Tyr Cys 
        1395                1400                1405


Glu Ile Cys Glu Met Phe Gly His Trp Ala Thr Asn Cys Asn Asp Asp 
    1410                1415                1420


Glu Thr Phe 
1425


<210>  923
<211>  5793
<212>  DNA
<213>  Homo sapiens

<400>  923
gctgctgctg cagtgggaca ggtggcggcg accggcggcg tccgaggaga tttaatccag     60

agactgactt cactatagaa cccacagttg tatcaatggt tggggaaaga tagtggcaac    120

aggcaaagga gaaacagctc tgacatacaa agaaaatgag tatgctaaag ccaagtgggc    180

ttaaggcccc caccaagatc ctgaagcctg gaagcacagc tctgaagaca cctacggctg    240

ttgtagctcc agtagaaaaa accatatcca gtgaaaaagc atcaagcact ccatcatctg    300

agactcagga ggaatttgtg gatgactttc gagttgggga gcgagtttgg gtgaatggaa    360

ataagcctgg atttatccag tttcttggag aaacccagtt tgcaccaggc cagtgggctg    420

gaattgtttt agatgaaccc ataggcaaga acgatggttc ggtggcagga gttcggtatt    480

tccagtgtga acctttaaag ggcatattta cccgaccttc aaagttaaca aggaaggtgc    540

aagcagaaga tgaagctaat ggcctgcaga caacgcccgc ctcccgagct acttcaccgc    600

tgtgcacttc tacggccagc atggtgtctt cctccccctc caccccttca aacatccctc    660

agaaaccatc acagccagca gcaaaggaac cttcagctac gcctccgatc agcaacctta    720

caaaaactgc cagtgaatct atctccaacc tttcagaggc tggctcaatc aagaaaggag    780

aaagagagct caaaatcgga gacagagtat tggttggtgg cactaaggct ggtgtagtcc    840

ggtttcttgg ggagaccgac tttgccaagg gggagtggtg tggcgtggag ttagatgagc    900

cacttgggaa gaatgatggc gctgttgctg gaacaaggta ttttcagtgt caacccaaat    960

atggcttgtt cgctcctgtc cacaaagtta ccaagattgg cttcccttcc actacaccag   1020

ccaaagccaa ggccaacgca gtgaggcgag tgatggcgac cacgtccgcc agcctgaagc   1080

gcagcccttc tgcctcttcc ctcagctcca tgagctcagt ggcctcctct gtgagcagca   1140

ggcccagtcg gacaggacta ttgactgaaa cctcctcccg ttacgccagg aagatctccg   1200

gtaccactgc cctccaggag gccctgaagg agaagcagca gcacattgag cagctgctgg   1260

cggaacggga tctggagagg gcggaggtgg ccaaggccac gagccacgtg ggggagatag   1320

agcaggagct agctctggcc cgggacggac atgaccagca tgtcctggaa ttggaagcca   1380

aaatggacca gctgcgaaca atggtggaag ctgctgacag ggagaaggtg gagcttctca   1440

accagcttga agaggagaaa aggaaggttg aggaccttca gttccgggtt gaagaagaat   1500

caattaccaa aggtgatctt gaggtggcta cagtttcaga aaagtcacgt ataatggaac   1560

tggagaaaga cctagcattg agagtacagg aagtagctga gctccgaaga aggctagagt   1620

ccaataagcc tgctggggat gtggacatgt cactttccct tttgcaagag ataagctctt   1680

tgcaagaaaa gttagaagtc acccgtactg accaccagag agaaataact tctctgaagg   1740

agcattttgg agcccgggaa gaaactcatc agaaggagat aaaggctctg tataccgcca   1800

cggaaaagct ttccaaagag aacgagtcat tgaaaagcaa gctggagcat gccaacaaag   1860

agaactcaga tgtgatagct ctatggaagt ccaaactgga gactgccatc gcatcccacc   1920

agcaggcgat ggaagaactg aaggtatctt tcagcaaagg gcttggaaca gagacggcag   1980

aatttgctga actaaaaaca caaatagaga aaatgagact agattaccaa cacgaaatag   2040

aaaatttgca gaatcaacaa gactctgaac gggctgccca tgctaaagag atggaagcct   2100

tgagggctaa actgatgaaa gttattaaag aaaaggaaaa cagtctggaa gccatcaggt   2160

cgaaactgga caaagcagaa gaccagcatc tcgtagaaat ggaagacacg ttaaacaaat   2220

tacaggaagc tgaaataaag gtaaaggagc tagaggtact gcaagccaaa tgcaatgaac   2280

aaaccaaggt tattgataat tttacatcac agctcaaggc tactgaagaa aagctcttgg   2340

atcttgatgc acttcggaaa gccagttccg aaggtaaatc ggaaatgaag aaacttagac   2400

agcagcttga ggcagctgag aaacagatta aacatttaga gattgaaaag aatgctgaaa   2460

gtagcaaggc tagtagcatt accagagagc tccaggggag agagctaaag cttactaacc   2520

ttcaggaaaa tttgagtgaa gtcagtcaag tgaaagagac tttggaaaaa gaacttcaga   2580

ttttgaaaga aaagtttgct gaagcttcag aggaggcagt ctctgttcag agaagtatgc   2640

aagaaactgt aaataagtta caccaaaagg aggaacagtt taacatgctg tcttctgact   2700

tggagaagct gagagaaaac ttagcagata tggaggcaaa atttagagag aaagatgaga   2760

gagaagagca gctgataaag gcaaaggaaa aactggaaaa tgacattgca gaaataatga   2820

agatgtcagg agataactct tctcagctga caaaaatgaa cgatgaatta cgtctgaaag   2880

aaagagatgt agaagaatta cagctaaaac ttacaaaggc taatgaaaat gcaagttttc   2940

tgcaaaaaag tattgaggac atgactgtca aagctgaaca gagccagcaa gaagcagcta   3000

aaaagcatga ggaagaaaag aaagaattgg agaggaaatt gtcggacctg gaaaagaaaa   3060

tggaaacaag ccacaaccag tgtcaggagc tgaaagccag gtatgagaga gccacttctg   3120

agacaaaaac caagcatgaa gaaatcctac agaacctcca gaagacgctg ctggacacag   3180

aggacaagct gaagggcgca cgggaggaga acagtggctt gctgcaggag ctggaggagc   3240

tgagaaagca agccgacaaa gccaaagctg ctcaaacagc ggaagatgcc atgcagataa   3300

tggaacagat gaccaaagag aagactgaga ctctggcctc cttggaggac accaagcaaa   3360

caaatgcaaa actacagaat gaattggaca cacttaaaga aaacaacttg aaaaatgtgg   3420

aagagctgaa caaatcaaaa gaactcctga ctgtagagaa tcaaaaaatg gaagaattta   3480

ggaaagaaat agaaacccta aagcaggcag cagctcagaa gtcccagcag ctttcagcgt   3540

tgcaagaaga gaacgttaaa cttgctgagg agctggggag aagcagggac gaagtcacaa   3600

gtcatcaaaa gctggaagaa gaaagatctg tgctcaataa tcagttgtta gaaatgaaaa   3660

aaagagaatc caagttcata aaagacgcag atgaagagaa agcttccttg cagaaatcca   3720

tcagtataac tagtgcctta ctcacagaaa aggatgccga gctggagaaa ctgagaaatg   3780

aggtcacagt gctcagggga gaaaacgcct ctgccaagtc cttgcattca gttgttcaga   3840

ctctagagtc tgataaggtg aagctcgagc tcaaggtaaa gaacttggag cttcaactca   3900

aagaaaacaa gaggcagctc agcagctcct caggtaatac agacactcag gcagacgagg   3960

atgaaagagc ccaggagagt cagattgatt tcctaaattc agtaatagtg gaccttcaaa   4020

ggaagaatca agacctcaag atgaaggtgg agatgatgtc agaagcagcc ctgaatggga   4080

acggggatga cctaaacaat tatgacagtg atgatcagga gaaacagtcc aagaagaaac   4140

ctcgcctctt ctgtgacatt tgtgactgct ttgatctcca cgacacagag gattgtccta   4200

cccaggcaca gatgtcagag gaccctcccc attccacaca ccatggcagt cggggtgagg   4260

aacgcccata ctgtgaaatc tgtgagatgt ttggacactg ggccaccaac tgcaatgacg   4320

acgaaacctt ctgatgaagc ctccagtgga gaactgggct tgctcagacg cactcgcatt   4380

gacacaacgt aacaccagca ttgtgtgtgc agacttcagg agaactcatg ttatttttta   4440

accccgtcaa caaatctagg aaaatatttt gatcttcaac aaattgccct ttagtctccc   4500

cgtatgagtt agaataataa atatttagta ggtgagtttt cacctcgaat tttgttttct   4560

tgatttttac gtttgaagac attgcaccag atgccattac atttattggc cccccgacct   4620

tgtagaaaaa cccctaccct cacaatacct tatttaagta actttaaatt atgccgttac   4680

ttttcatatt tgcactaaga tatttccagg ctgcatttgt atatttagat tttttggtta   4740

agctttgaca ctggaatgag ttgaaaaaat gtgccatttt gcattttcat ctactcattt   4800

aaagtatttt attcttattc aaagaaatat ctgagctctt tgcactacct gttatcagta   4860

gtgcctttac ttcaggcttg ataatactta ggtgtgatta taaaatcatg aagcaggtaa   4920

agggaggggc aagcccccaa actgctgtgg ggacatttta taatctatat gctgcaccca   4980

cttaatctac tgtggtgttt tgtttattag ttttgcataa tttcagcttc tatatattgt   5040

atgtatatat tttttaaaaa tctatatttt gggaaaaaaa catacacaat gtgtctttct   5100

ttttggacat ttaccttttt gaaaaagaaa acacttaaaa tgatcattag gacataacag   5160

actaggccag acatagcatc ttgtggcttt gcaaccattt tcatttgttt gttttccttt   5220

tatttcttca ccagatttaa ataactggag gaattttctc caattttttt ttccttctct   5280

ggcaggtatc cccagcagtc aattaacaat aagccagtat aaaacaccta aataaccaat   5340

ctacaatctc ccttcacaag tttttttact gtttttagat gaatgtacga tgagaaattc   5400

aacgttaata attctggatt ttcttatcac aaaaaagaaa atgaaggacc tcaaagcacc   5460

tgaacagttt atcgaccagt ttgaatctat ttatcttcat ttgaatgtct tctagaatat   5520

gtaaaaagtc ataaaatgta tcttccatgc tacatgtaca ataagaactt ctataattgt   5580

atatatgcct ttgatgtatt ttcccctcaa gattatcaac tgtgtgttcg acagtgaata   5640

ttcaatctgg taccagttga aatttttggt tataaatgta atacgaattg tttcacaaac   5700

agaaaacatg taaagcagta ttaaaatttg gccaaacaag tgttctgtat ctactttaat   5760

aaatggttat tctttaaaaa aaaaaaaaaa aaa                                5793


<210>  924
<211>  1392
<212>  PRT
<213>  Homo sapiens

<400>  924

Met Ser Met Leu Lys Pro Ser Gly Leu Lys Ala Pro Thr Lys Ile Leu 
1               5                   10                  15


Lys Pro Gly Ser Thr Ala Leu Lys Thr Pro Thr Ala Val Val Ala Pro 
            20                  25                  30


Val Glu Lys Thr Ile Ser Ser Glu Lys Ala Ser Ser Thr Pro Ser Ser 
        35                  40                  45


Glu Thr Gln Glu Glu Phe Val Asp Asp Phe Arg Val Gly Glu Arg Val 
    50                  55                  60


Trp Val Asn Gly Asn Lys Pro Gly Phe Ile Gln Phe Leu Gly Glu Thr 
65                  70                  75                  80


Gln Phe Ala Pro Gly Gln Trp Ala Gly Ile Val Leu Asp Glu Pro Ile 
                85                  90                  95


Gly Lys Asn Asp Gly Ser Val Ala Gly Val Arg Tyr Phe Gln Cys Glu 
            100                 105                 110


Pro Leu Lys Gly Ile Phe Thr Arg Pro Ser Lys Leu Thr Arg Lys Val 
        115                 120                 125


Gln Ala Glu Asp Glu Ala Asn Gly Leu Gln Thr Thr Pro Ala Ser Arg 
    130                 135                 140


Ala Thr Ser Pro Leu Cys Thr Ser Thr Ala Ser Met Val Ser Ser Ser 
145                 150                 155                 160


Pro Ser Thr Pro Ser Asn Ile Pro Gln Lys Pro Ser Gln Pro Ala Ala 
                165                 170                 175


Lys Glu Pro Ser Ala Thr Pro Pro Ile Ser Asn Leu Thr Lys Thr Ala 
            180                 185                 190


Ser Glu Ser Ile Ser Asn Leu Ser Glu Ala Gly Ser Ile Lys Lys Gly 
        195                 200                 205


Glu Arg Glu Leu Lys Ile Gly Asp Arg Val Leu Val Gly Gly Thr Lys 
    210                 215                 220


Ala Gly Val Val Arg Phe Leu Gly Glu Thr Asp Phe Ala Lys Gly Glu 
225                 230                 235                 240


Trp Cys Gly Val Glu Leu Asp Glu Pro Leu Gly Lys Asn Asp Gly Ala 
                245                 250                 255


Val Ala Gly Thr Arg Tyr Phe Gln Cys Gln Pro Lys Tyr Gly Leu Phe 
            260                 265                 270


Ala Pro Val His Lys Val Thr Lys Ile Gly Phe Pro Ser Thr Thr Pro 
        275                 280                 285


Ala Lys Ala Lys Ala Asn Ala Val Arg Arg Val Met Ala Thr Thr Ser 
    290                 295                 300


Ala Ser Leu Lys Arg Ser Pro Ser Ala Ser Ser Leu Ser Ser Met Ser 
305                 310                 315                 320


Ser Val Ala Ser Ser Val Ser Ser Arg Pro Ser Arg Thr Gly Leu Leu 
                325                 330                 335


Thr Glu Thr Ser Ser Arg Tyr Ala Arg Lys Ile Ser Gly Thr Thr Ala 
            340                 345                 350


Leu Gln Glu Ala Leu Lys Glu Lys Gln Gln His Ile Glu Gln Leu Leu 
        355                 360                 365


Ala Glu Arg Asp Leu Glu Arg Ala Glu Val Ala Lys Ala Thr Ser His 
    370                 375                 380


Val Gly Glu Ile Glu Gln Glu Leu Ala Leu Ala Arg Asp Gly His Asp 
385                 390                 395                 400


Gln His Val Leu Glu Leu Glu Ala Lys Met Asp Gln Leu Arg Thr Met 
                405                 410                 415


Val Glu Ala Ala Asp Arg Glu Lys Val Glu Leu Leu Asn Gln Leu Glu 
            420                 425                 430


Glu Glu Lys Arg Lys Val Glu Asp Leu Gln Phe Arg Val Glu Glu Glu 
        435                 440                 445


Ser Ile Thr Lys Gly Asp Leu Glu Val Ala Thr Val Ser Glu Lys Ser 
    450                 455                 460


Arg Ile Met Glu Leu Glu Lys Asp Leu Ala Leu Arg Val Gln Glu Val 
465                 470                 475                 480


Ala Glu Leu Arg Arg Arg Leu Glu Ser Asn Lys Pro Ala Gly Asp Val 
                485                 490                 495


Asp Met Ser Leu Ser Leu Leu Gln Glu Ile Ser Ser Leu Gln Glu Lys 
            500                 505                 510


Leu Glu Val Thr Arg Thr Asp His Gln Arg Glu Ile Thr Ser Leu Lys 
        515                 520                 525


Glu His Phe Gly Ala Arg Glu Glu Thr His Gln Lys Glu Ile Lys Ala 
    530                 535                 540


Leu Tyr Thr Ala Thr Glu Lys Leu Ser Lys Glu Asn Glu Ser Leu Lys 
545                 550                 555                 560


Ser Lys Leu Glu His Ala Asn Lys Glu Asn Ser Asp Val Ile Ala Leu 
                565                 570                 575


Trp Lys Ser Lys Leu Glu Thr Ala Ile Ala Ser His Gln Gln Ala Met 
            580                 585                 590


Glu Glu Leu Lys Val Ser Phe Ser Lys Gly Leu Gly Thr Glu Thr Ala 
        595                 600                 605


Glu Phe Ala Glu Leu Lys Thr Gln Ile Glu Lys Met Arg Leu Asp Tyr 
    610                 615                 620


Gln His Glu Ile Glu Asn Leu Gln Asn Gln Gln Asp Ser Glu Arg Ala 
625                 630                 635                 640


Ala His Ala Lys Glu Met Glu Ala Leu Arg Ala Lys Leu Met Lys Val 
                645                 650                 655


Ile Lys Glu Lys Glu Asn Ser Leu Glu Ala Ile Arg Ser Lys Leu Asp 
            660                 665                 670


Lys Ala Glu Asp Gln His Leu Val Glu Met Glu Asp Thr Leu Asn Lys 
        675                 680                 685


Leu Gln Glu Ala Glu Ile Lys Val Lys Glu Leu Glu Val Leu Gln Ala 
    690                 695                 700


Lys Cys Asn Glu Gln Thr Lys Val Ile Asp Asn Phe Thr Ser Gln Leu 
705                 710                 715                 720


Lys Ala Thr Glu Glu Lys Leu Leu Asp Leu Asp Ala Leu Arg Lys Ala 
                725                 730                 735


Ser Ser Glu Gly Lys Ser Glu Met Lys Lys Leu Arg Gln Gln Leu Glu 
            740                 745                 750


Ala Ala Glu Lys Gln Ile Lys His Leu Glu Ile Glu Lys Asn Ala Glu 
        755                 760                 765


Ser Ser Lys Ala Ser Ser Ile Thr Arg Glu Leu Gln Gly Arg Glu Leu 
    770                 775                 780


Lys Leu Thr Asn Leu Gln Glu Asn Leu Ser Glu Val Ser Gln Val Lys 
785                 790                 795                 800


Glu Thr Leu Glu Lys Glu Leu Gln Ile Leu Lys Glu Lys Phe Ala Glu 
                805                 810                 815


Ala Ser Glu Glu Ala Val Ser Val Gln Arg Ser Met Gln Glu Thr Val 
            820                 825                 830


Asn Lys Leu His Gln Lys Glu Glu Gln Phe Asn Met Leu Ser Ser Asp 
        835                 840                 845


Leu Glu Lys Leu Arg Glu Asn Leu Ala Asp Met Glu Ala Lys Phe Arg 
    850                 855                 860


Glu Lys Asp Glu Arg Glu Glu Gln Leu Ile Lys Ala Lys Glu Lys Leu 
865                 870                 875                 880


Glu Asn Asp Ile Ala Glu Ile Met Lys Met Ser Gly Asp Asn Ser Ser 
                885                 890                 895


Gln Leu Thr Lys Met Asn Asp Glu Leu Arg Leu Lys Glu Arg Asp Val 
            900                 905                 910


Glu Glu Leu Gln Leu Lys Leu Thr Lys Ala Asn Glu Asn Ala Ser Phe 
        915                 920                 925


Leu Gln Lys Ser Ile Glu Asp Met Thr Val Lys Ala Glu Gln Ser Gln 
    930                 935                 940


Gln Glu Ala Ala Lys Lys His Glu Glu Glu Lys Lys Glu Leu Glu Arg 
945                 950                 955                 960


Lys Leu Ser Asp Leu Glu Lys Lys Met Glu Thr Ser His Asn Gln Cys 
                965                 970                 975


Gln Glu Leu Lys Ala Arg Tyr Glu Arg Ala Thr Ser Glu Thr Lys Thr 
            980                 985                 990


Lys His Glu Glu Ile Leu Gln Asn Leu Gln Lys Thr Leu Leu Asp Thr 
        995                 1000                1005


Glu Asp Lys Leu Lys Gly Ala Arg Glu Glu Asn Ser Gly Leu Leu Gln 
    1010                1015                1020


Glu Leu Glu Glu Leu Arg Lys Gln Ala Asp Lys Ala Lys Ala Ala Gln 
1025                1030                1035                1040


Thr Ala Glu Asp Ala Met Gln Ile Met Glu Gln Met Thr Lys Glu Lys 
                1045                1050                1055


Thr Glu Thr Leu Ala Ser Leu Glu Asp Thr Lys Gln Thr Asn Ala Lys 
            1060                1065                1070


Leu Gln Asn Glu Leu Asp Thr Leu Lys Glu Asn Asn Leu Lys Asn Val 
        1075                1080                1085


Glu Glu Leu Asn Lys Ser Lys Glu Leu Leu Thr Val Glu Asn Gln Lys 
    1090                1095                1100


Met Glu Glu Phe Arg Lys Glu Ile Glu Thr Leu Lys Gln Ala Ala Ala 
1105                1110                1115                1120


Gln Lys Ser Gln Gln Leu Ser Ala Leu Gln Glu Glu Asn Val Lys Leu 
                1125                1130                1135


Ala Glu Glu Leu Gly Arg Ser Arg Asp Glu Val Thr Ser His Gln Lys 
            1140                1145                1150


Leu Glu Glu Glu Arg Ser Val Leu Asn Asn Gln Leu Leu Glu Met Lys 
        1155                1160                1165


Lys Arg Glu Ser Lys Phe Ile Lys Asp Ala Asp Glu Glu Lys Ala Ser 
    1170                1175                1180


Leu Gln Lys Ser Ile Ser Ile Thr Ser Ala Leu Leu Thr Glu Lys Asp 
1185                1190                1195                1200


Ala Glu Leu Glu Lys Leu Arg Asn Glu Val Thr Val Leu Arg Gly Glu 
                1205                1210                1215


Asn Ala Ser Ala Lys Ser Leu His Ser Val Val Gln Thr Leu Glu Ser 
            1220                1225                1230


Asp Lys Val Lys Leu Glu Leu Lys Val Lys Asn Leu Glu Leu Gln Leu 
        1235                1240                1245


Lys Glu Asn Lys Arg Gln Leu Ser Ser Ser Ser Gly Asn Thr Asp Thr 
    1250                1255                1260


Gln Ala Asp Glu Asp Glu Arg Ala Gln Glu Ser Gln Ile Asp Phe Leu 
1265                1270                1275                1280


Asn Ser Val Ile Val Asp Leu Gln Arg Lys Asn Gln Asp Leu Lys Met 
                1285                1290                1295


Lys Val Glu Met Met Ser Glu Ala Ala Leu Asn Gly Asn Gly Asp Asp 
            1300                1305                1310


Leu Asn Asn Tyr Asp Ser Asp Asp Gln Glu Lys Gln Ser Lys Lys Lys 
        1315                1320                1325


Pro Arg Leu Phe Cys Asp Ile Cys Asp Cys Phe Asp Leu His Asp Thr 
    1330                1335                1340


Glu Asp Cys Pro Thr Gln Ala Gln Met Ser Glu Asp Pro Pro His Ser 
1345                1350                1355                1360


Thr His His Gly Ser Arg Gly Glu Glu Arg Pro Tyr Cys Glu Ile Cys 
                1365                1370                1375


Glu Met Phe Gly His Trp Ala Thr Asn Cys Asn Asp Asp Glu Thr Phe 
            1380                1385                1390


<210>  925
<211>  738
<212>  DNA
<213>  Homo sapiens

<400>  925
atgaagtgga gaaacagccg gattcaggat tcacccccga atcaaaaccc gatttttgaa     60

aggcaggacc ttccaattcg gctccggagg agccccccag ggacccccgg cctccggcgc    120

cggccacccg agactcccgc ggtcccctcc cggacggctc cggcgcgcga ggctcggccc    180

cgctcccgga cgccgggctt cgacccccga cccgaccctg ggcgggcccc gcaggccggg    240

aagccggcag gggagcaggg ggtgccggga aagggagagg gcccgcgccg ccccctgctc    300

acctcctcgg acgccgccgg tcgccgccac ctgtcccact gcagcagcag cagccgccgc    360

ggccgccgcc tcccgcctcc cggctcgtcg gctcggggcg ggggagagcg tgacgcgccg    420

ccgccgccgc ggggccgggc gggcgcgcgc tgccaggaga agacgccgcg cggctcctcc    480

cagcgctccg ccgccgcgcc cgcccggccg acaagggtga gaaatccttt gaaacaggct    540

gcaaggcgct tccgaagcag gttaagttgg ggattgggaa ggatcatctc tgccctcgcc    600

tccctccagg gaaagaccct ggatgaggcg tccctggaga aaatgctgaa aggaactgta    660

gagcaggtta agcttgggaa gaactgtatc tgctccccac ttccctccgg gaacgaccgc    720

gggttaaaaa tcctttga                                                  738


<210>  926
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  926

Met Lys Trp Arg Asn Ser Arg Ile Gln Asp Ser Pro Pro Asn Gln Asn 
1               5                   10                  15


Pro Ile Phe Glu Arg Gln Asp Leu Pro Ile Arg Leu Arg Arg Ser Pro 
            20                  25                  30


Pro Gly Thr Pro Gly Leu Arg Arg Arg Pro Pro Glu Thr Pro Ala Val 
        35                  40                  45


Pro Ser Arg Thr Ala Pro Ala Arg Glu Ala Arg Pro Arg Ser Arg Thr 
    50                  55                  60


Pro Gly Phe Asp Pro Arg Pro Asp Pro Gly Arg Ala Pro Gln Ala Gly 
65                  70                  75                  80


Lys Pro Ala Gly Glu Gln Gly Val Pro Gly Lys Gly Glu Gly Pro Arg 
                85                  90                  95


Arg Pro Leu Leu Thr Ser Ser Asp Ala Ala Gly Arg Arg His Leu Ser 
            100                 105                 110


His Cys Ser Ser Ser Ser Arg Arg Gly Arg Arg Leu Pro Pro Pro Gly 
        115                 120                 125


Ser Ser Ala Arg Gly Gly Gly Glu Arg Asp Ala Pro Pro Pro Pro Arg 
    130                 135                 140


Gly Arg Ala Gly Ala Arg Cys Gln Glu Lys Thr Pro Arg Gly Ser Ser 
145                 150                 155                 160


Gln Arg Ser Ala Ala Ala Pro Ala Arg Pro Thr Arg Val Arg Asn Pro 
                165                 170                 175


Leu Lys Gln Ala Ala Arg Arg Phe Arg Ser Arg Leu Ser Trp Gly Leu 
            180                 185                 190


Gly Arg Ile Ile Ser Ala Leu Ala Ser Leu Gln Gly Lys Thr Leu Asp 
        195                 200                 205


Glu Ala Ser Leu Glu Lys Met Leu Lys Gly Thr Val Glu Gln Val Lys 
    210                 215                 220


Leu Gly Lys Asn Cys Ile Cys Ser Pro Leu Pro Ser Gly Asn Asp Arg 
225                 230                 235                 240


Gly Leu Lys Ile Leu 
                245


<210>  927
<211>  2874
<212>  DNA
<213>  Homo sapiens

<400>  927
gcgtctggag aaaaccctag cgggtggctc cgtgcggcca gagctctaga gagtggtgcc     60

gccttccaac cttcttcccc aagccctggt ggccggctcc gcctcttctc gaatcttttc    120

cacagcccaa aatggccgca gaggtgtatt ttggcgatct agagctcttc gagccgttcg    180

accacccaga ggagtcgatt ccgaagcccg ttcacactcg cttcaaggac gacgacggcg    240

acgaggagga cgaaaatggg gtcggcgacg cggagctacg ggagcggctt cggcagtgcg    300

aggagaccat cgagcagctc cgcgccgaga atcaagaact taaacgaaaa ttgaacattc    360

tgactcgacc gagtggaata ttggtgaacg atactaagtt agatggacct atattacaga    420

ttctattcat gaacaatgct atttcaaagc aatatcatca agaaatagag gaatttgtat    480

caaatttagt aaaaagattt gaggaacagc agaaaaatga tgtggaaaag acttccttta    540

atcttttgcc ccagccatcc agtattgtgc tagaggagga ccacaaagtg gaagagtcct    600

gtgccattaa aaacaacaag gaagctttca gtgttgtagg aagtgtcctg tattttacta    660

atttttgcct tgataaattg gggcaaccgc ttctaaatga aaaccctcag ctttccgaag    720

gatgggaaat acccaagtac catcaagtct tcagccacat tgtttctcta gaagggcaag    780

aaatacaagt aaaggcaaaa aggccaaagc ctcactgttt caattgtggt tctgaagaac    840

accaaatgaa agattgccca atgcctcgga atgctgctcg aataagtgaa aagagaaaag    900

agtatatgga tgcctgtgga gaagcaaaca atcagaattt ccagcagcga taccacgcag    960

aagaagtaga agaaagattt ggaagattca agccaggagt tattagtgag gaacttcaag   1020

atgcactagg tgtgacagac aagagtcttc caccttttat ctatcggatg cgccagctag   1080

ggtacccacc agggtggctc aaagaggctg aattggagaa ttcggggctt gcactctatg   1140

atggaaaaga tggcactgat ggggaaacag aagttggaga aatacaacag aataaaagtg   1200

tcacttacga tctctcaaaa ttggtcaact atcctggttt taatatatct actcccagag   1260

gaattccaga cgaatggagg atctttggtt ccataccaat gcaggcatgt cagcagaagg   1320

atgtgtttgc caattacctt acttctaact tccaagcgcc aggtgtgaag tctggcaaca   1380

agaggtcttc atctcactct agcccaggta gtccaaagaa gcagaagaat gaaagcaact   1440

cagcgggatc tcccgccgac atggagctcg attcagatat ggaggtacca catggttctc   1500

agagcagcga aagttttcag tttcaaccac cattacctcc tgacactcct ccactccccc   1560

ggggaactcc tccacccgtc ttcacccctc cactcccaaa gggcaccccg ccgctgactc   1620

ccagtgactc accccagacc agaacagcat ctggagctgt ggatgaggac gcactgactc   1680

tagaagaact tgaagaacag cagaggcgga tctgggcagc tcttgagcag gccgagagcg   1740

taaacagcga ctccgacgtt cctgtggaca cacctttaac tggcaattcc gttgcctcat   1800

caccttgtcc aaatgagcta gacctccctg tcccggaggg aaaaacatct gaaaagcaga   1860

cgctggatga gcctgaggta ccagagattt ttacaaagaa atcagaagct ggacatgcct   1920

ccagtccaga ctctgaggtg acatcacttt gtcagaagga aaaagcagag ttggctccgg   1980

taaacactga aggtgccctt cttgataatg gcagtgtcgt accaaactgt gacatcagca   2040

atgggggcag ccagaagctc tttcctgcag acaccagtcc ttcaacggcc actaaaattc   2100

atagccctat acctgacatg agcaaatttg caactggaat cacgccattt gaatttgaga   2160

atatggcaga atctactgga atgtacctca ggataagaag cttgttaaag aactcacccc   2220

gaaaccagca gaaaaacaaa aaggcctctg aataatggct tgacttagca ctgagagcta   2280

tttaataact ttgttccgtt aattagtact aattaagtgg atagatagaa tggttttcct   2340

gtttgtccct cccatgttta aaaatctatc caaggttcat gttccaaagt caagcctatt   2400

ttaaagaaag actgagctca ctagttcagt atattttatt ctcactgaca aaacttgggg   2460

ggagatgtga atatgacctg gtttagagag ggtttgttaa ggtttatact atttttggat   2520

tgtgactatc cgtcgagagt gatggttttt atctgtcttt tgtacattgt tttccctttc   2580

tacattttgc taattatcct gtatataagt ttaatatatc actttttaaa agaaaaaatt   2640

ctaccatttt aaattcatgt ttcaactcct acaaccaaat gagaaaaatc agggatgagc   2700

agctttatcc catttggggt atttttgtaa gtgatttaca tgtgtcaatt ttagtaatac   2760

ttttactttt ttgtaacttc atccttcata tatgcttgct atacaggtat gttcatcttt   2820

gtgtacagag gtttaataaa ttagttttca tatacataat ctaaaaaaaa aaaa         2874


<210>  928
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  928

Met Ala Ala Glu Val Tyr Phe Gly Asp Leu Glu Leu Phe Glu Pro Phe 
1               5                   10                  15


Asp His Pro Glu Glu Ser Ile Pro Lys Pro Val His Thr Arg Phe Lys 
            20                  25                  30


Asp Asp Asp Gly Asp Glu Glu Asp Glu Asn Gly Val Gly Asp Ala Glu 
        35                  40                  45


Leu Arg Glu Arg Leu Arg Gln Cys Glu Glu Thr Ile Glu Gln Leu Arg 
    50                  55                  60


Ala Glu Asn Gln Glu Leu Lys Arg Lys Leu Asn Ile Leu Thr Arg Pro 
65                  70                  75                  80


Ser Gly Ile Leu Val Asn Asp Thr Lys Leu Asp Gly Pro Ile Leu Gln 
                85                  90                  95


Ile Leu Phe Met Asn Asn Ala Ile Ser Lys Gln Tyr His Gln Glu Ile 
            100                 105                 110


Glu Glu Phe Val Ser Asn Leu Val Lys Arg Phe Glu Glu Gln Gln Lys 
        115                 120                 125


Asn Asp Val Glu Lys Thr Ser Phe Asn Leu Leu Pro Gln Pro Ser Ser 
    130                 135                 140


Ile Val Leu Glu Glu Asp His Lys Val Glu Glu Ser Cys Ala Ile Lys 
145                 150                 155                 160


Asn Asn Lys Glu Ala Phe Ser Val Val Gly Ser Val Leu Tyr Phe Thr 
                165                 170                 175


Asn Phe Cys Leu Asp Lys Leu Gly Gln Pro Leu Leu Asn Glu Asn Pro 
            180                 185                 190


Gln Leu Ser Glu Gly Trp Glu Ile Pro Lys Tyr His Gln Val Phe Ser 
        195                 200                 205


His Ile Val Ser Leu Glu Gly Gln Glu Ile Gln Val Lys Ala Lys Arg 
    210                 215                 220


Pro Lys Pro His Cys Phe Asn Cys Gly Ser Glu Glu His Gln Met Lys 
225                 230                 235                 240


Asp Cys Pro Met Pro Arg Asn Ala Ala Arg Ile Ser Glu Lys Arg Lys 
                245                 250                 255


Glu Tyr Met Asp Ala Cys Gly Glu Ala Asn Asn Gln Asn Phe Gln Gln 
            260                 265                 270


Arg Tyr His Ala Glu Glu Val Glu Glu Arg Phe Gly Arg Phe Lys Pro 
        275                 280                 285


Gly Val Ile Ser Glu Glu Leu Gln Asp Ala Leu Gly Val Thr Asp Lys 
    290                 295                 300


Ser Leu Pro Pro Phe Ile Tyr Arg Met Arg Gln Leu Gly Tyr Pro Pro 
305                 310                 315                 320


Gly Trp Leu Lys Glu Ala Glu Leu Glu Asn Ser Gly Leu Ala Leu Tyr 
                325                 330                 335


Asp Gly Lys Asp Gly Thr Asp Gly Glu Thr Glu Val Gly Glu Ile Gln 
            340                 345                 350


Gln Asn Lys Ser Val Thr Tyr Asp Leu Ser Lys Leu Val Asn Tyr Pro 
        355                 360                 365


Gly Phe Asn Ile Ser Thr Pro Arg Gly Ile Pro Asp Glu Trp Arg Ile 
    370                 375                 380


Phe Gly Ser Ile Pro Met Gln Ala Cys Gln Gln Lys Asp Val Phe Ala 
385                 390                 395                 400


Asn Tyr Leu Thr Ser Asn Phe Gln Ala Pro Gly Val Lys Ser Gly Asn 
                405                 410                 415


Lys Arg Ser Ser Ser His Ser Ser Pro Gly Ser Pro Lys Lys Gln Lys 
            420                 425                 430


Asn Glu Ser Asn Ser Ala Gly Ser Pro Ala Asp Met Glu Leu Asp Ser 
        435                 440                 445


Asp Met Glu Val Pro His Gly Ser Gln Ser Ser Glu Ser Phe Gln Phe 
    450                 455                 460


Gln Pro Pro Leu Pro Pro Asp Thr Pro Pro Leu Pro Arg Gly Thr Pro 
465                 470                 475                 480


Pro Pro Val Phe Thr Pro Pro Leu Pro Lys Gly Thr Pro Pro Leu Thr 
                485                 490                 495


Pro Ser Asp Ser Pro Gln Thr Arg Thr Ala Ser Gly Ala Val Asp Glu 
            500                 505                 510


Asp Ala Leu Thr Leu Glu Glu Leu Glu Glu Gln Gln Arg Arg Ile Trp 
        515                 520                 525


Ala Ala Leu Glu Gln Ala Glu Ser Val Asn Ser Asp Ser Asp Val Pro 
    530                 535                 540


Val Asp Thr Pro Leu Thr Gly Asn Ser Val Ala Ser Ser Pro Cys Pro 
545                 550                 555                 560


Asn Glu Leu Asp Leu Pro Val Pro Glu Gly Lys Thr Ser Glu Lys Gln 
                565                 570                 575


Thr Leu Asp Glu Pro Glu Val Pro Glu Ile Phe Thr Lys Lys Ser Glu 
            580                 585                 590


Ala Gly His Ala Ser Ser Pro Asp Ser Glu Val Thr Ser Leu Cys Gln 
        595                 600                 605


Lys Glu Lys Ala Glu Leu Ala Pro Val Asn Thr Glu Gly Ala Leu Leu 
    610                 615                 620


Asp Asn Gly Ser Val Val Pro Asn Cys Asp Ile Ser Asn Gly Gly Ser 
625                 630                 635                 640


Gln Lys Leu Phe Pro Ala Asp Thr Ser Pro Ser Thr Ala Thr Lys Ile 
                645                 650                 655


His Ser Pro Ile Pro Asp Met Ser Lys Phe Ala Thr Gly Ile Thr Pro 
            660                 665                 670


Phe Glu Phe Glu Asn Met Ala Glu Ser Thr Gly Met Tyr Leu Arg Ile 
        675                 680                 685


Arg Ser Leu Leu Lys Asn Ser Pro Arg Asn Gln Gln Lys Asn Lys Lys 
    690                 695                 700


Ala Ser Glu 
705


<210>  929
<211>  2252
<212>  DNA
<213>  Homo sapiens

<400>  929
agctgtgcga cgcgccgggc ctcctcgcct ttgtgccatc cgggtctctc gcgcgagcga     60

tttagtctga ggcgaagctt cggagcggcc ggtactgttg aaagcgacaa gtggaggcgc    120

cgctctagcg gccgggactc tgaactatgg cggctagtga tacagagcga gatggactag    180

ccccagaaaa gacatcacca gatagagata agaaaaaaga gcagtcagaa gtatctgttt    240

ctcctagagc ttcaaaacat cattattcaa gatcacgatc aaggtcaaga gaaagaaaac    300

gaaagtcaga taatgaagga agaaaacaca ggagccggag cagaagcaaa gagggaagaa    360

gacatgaatc caaagataaa tcctctaaga aacataagtc tgaggaacat aatgacaaag    420

aacattcttc tgataaagga agagagcgac taaattcatc tgaaaatggt gaggacaggc    480

acaaacgcaa agaaagaaag tcatcaagag gcagaagtca ctcaagatct aggtctcgtg    540

aaagacgcca tcgtagtaga agcagggagc ggaagaagtc tcgatccagg agtagggagc    600

ggaagaaatc gagatccaga agcagagaga ggaagaaatc gagatccaga agcagggaaa    660

gaaaacggcg gatcaggtct cgttcccgct caagatcaag acacaggcat aggactagaa    720

gcaggagtag gacaaggagt aggagtcgag atagaaagaa gagaattgaa aagccgagaa    780

gatttagcag aagtttaagc cggactccaa gtccacctcc cttcagaggc agaaacacag    840

caatggatgc acaggaagct ttagctagaa ggttggaaag ggcaaagaaa ttacaagaac    900

agcgagaaaa ggaaatggtt gaaaaacaaa aacaacaaga aatagctgca gctgcagcta    960

ctggaggttc tgttctcaat gttgctgccc tgttggcatc aggaacacaa gtaacacctc   1020

agatagccat ggcagctcag atggcagccc tgcaagctaa agctttggca gagacaggaa   1080

tagctgttcc tagctactat aacccagccg ctgttaatcc aatgaaattt gctgaacaag   1140

agaaaaaaag gaaaatgctt tggcagggca agaaagaagg ggacaaatcc caatctgctg   1200

aaatatggga aaaattgaat tttggaaaca aggaccaaaa tgtcaaattt aggaaattga   1260

tgggtattaa gagtgaagat gaagctggat gtagctcagt tgatgaagaa agttacaaga   1320

ctctgaagca gcaggaagaa gtatttcgaa atttagatgc tcagtatgaa atggcaagat   1380

cacaaaccca cacacaaaga ggaatgggtt tgggtttcac atcttcaatg cgaggaatgg   1440

atgcagtttg aaaatgatca cacttgtaaa gtttgggact tatagacttc ttgttctgat   1500

gtcacgtcct tgttcaccaa acagctagca ctctagcttg catgggtgtt gcattgactt   1560

taatttattg aaaaatacaa atttttgtaa atatcagatc agtgatactg gtgttagtgt   1620

tgtaatcagg ttaaacccac ttccattaaa cttgacagga ctatagaagg ataatatttt   1680

ttagttcatg aattctactt ttcaaatata taaaagctgc aggtggggat aaaatctcat   1740

acatggattt tttcgtgtcc gctgtcttgt gtacttttgt acttaacctt gtacagttat   1800

tttcatctct tgaaacatga aagaaatgtt atgtagatgt tctttagaag atctggccat   1860

ttggtacata atccagcaca gataagctgg gtggtaatga taataaaaat ggttttctca   1920

aaactggtgt taatttaagt tacctgggat gtttctttga atttgtttta tagtttctgt   1980

agcatttggc aattgctgtt agaaaacact agctagaaat cccctcccca ccaccctttt   2040

taaggccagt taactatact acagtcaata ccgtggtgag caaaaatgta aaaggtggaa   2100

ggagaaaact tactaaaata gtatgttttc ctattataag ggacagactt ggtattcagt   2160

atttgtcaaa tattacatgt gttattcagg agatagatta atgcattaaa gggatgtaag   2220

cacttttatt ttaataaagt gccttataac aa                                 2252


<210>  930
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  930

Met Ala Ala Ser Asp Thr Glu Arg Asp Gly Leu Ala Pro Glu Lys Thr 
1               5                   10                  15


Ser Pro Asp Arg Asp Lys Lys Lys Glu Gln Ser Glu Val Ser Val Ser 
            20                  25                  30


Pro Arg Ala Ser Lys His His Tyr Ser Arg Ser Arg Ser Arg Ser Arg 
        35                  40                  45


Glu Arg Lys Arg Lys Ser Asp Asn Glu Gly Arg Lys His Arg Ser Arg 
    50                  55                  60


Ser Arg Ser Lys Glu Gly Arg Arg His Glu Ser Lys Asp Lys Ser Ser 
65                  70                  75                  80


Lys Lys His Lys Ser Glu Glu His Asn Asp Lys Glu His Ser Ser Asp 
                85                  90                  95


Lys Gly Arg Glu Arg Leu Asn Ser Ser Glu Asn Gly Glu Asp Arg His 
            100                 105                 110


Lys Arg Lys Glu Arg Lys Ser Ser Arg Gly Arg Ser His Ser Arg Ser 
        115                 120                 125


Arg Ser Arg Glu Arg Arg His Arg Ser Arg Ser Arg Glu Arg Lys Lys 
    130                 135                 140


Ser Arg Ser Arg Ser Arg Glu Arg Lys Lys Ser Arg Ser Arg Ser Arg 
145                 150                 155                 160


Glu Arg Lys Lys Ser Arg Ser Arg Ser Arg Glu Arg Lys Arg Arg Ile 
                165                 170                 175


Arg Ser Arg Ser Arg Ser Arg Ser Arg His Arg His Arg Thr Arg Ser 
            180                 185                 190


Arg Ser Arg Thr Arg Ser Arg Ser Arg Asp Arg Lys Lys Arg Ile Glu 
        195                 200                 205


Lys Pro Arg Arg Phe Ser Arg Ser Leu Ser Arg Thr Pro Ser Pro Pro 
    210                 215                 220


Pro Phe Arg Gly Arg Asn Thr Ala Met Asp Ala Gln Glu Ala Leu Ala 
225                 230                 235                 240


Arg Arg Leu Glu Arg Ala Lys Lys Leu Gln Glu Gln Arg Glu Lys Glu 
                245                 250                 255


Met Val Glu Lys Gln Lys Gln Gln Glu Ile Ala Ala Ala Ala Ala Thr 
            260                 265                 270


Gly Gly Ser Val Leu Asn Val Ala Ala Leu Leu Ala Ser Gly Thr Gln 
        275                 280                 285


Val Thr Pro Gln Ile Ala Met Ala Ala Gln Met Ala Ala Leu Gln Ala 
    290                 295                 300


Lys Ala Leu Ala Glu Thr Gly Ile Ala Val Pro Ser Tyr Tyr Asn Pro 
305                 310                 315                 320


Ala Ala Val Asn Pro Met Lys Phe Ala Glu Gln Glu Lys Lys Arg Lys 
                325                 330                 335


Met Leu Trp Gln Gly Lys Lys Glu Gly Asp Lys Ser Gln Ser Ala Glu 
            340                 345                 350


Ile Trp Glu Lys Leu Asn Phe Gly Asn Lys Asp Gln Asn Val Lys Phe 
        355                 360                 365


Arg Lys Leu Met Gly Ile Lys Ser Glu Asp Glu Ala Gly Cys Ser Ser 
    370                 375                 380


Val Asp Glu Glu Ser Tyr Lys Thr Leu Lys Gln Gln Glu Glu Val Phe 
385                 390                 395                 400


Arg Asn Leu Asp Ala Gln Tyr Glu Met Ala Arg Ser Gln Thr His Thr 
                405                 410                 415


Gln Arg Gly Met Gly Leu Gly Phe Thr Ser Ser Met Arg Gly Met Asp 
            420                 425                 430


Ala Val 



<210>  931
<211>  2352
<212>  DNA
<213>  Homo sapiens

<400>  931
agctgtgcga cgcgccgggc ctcctcgcct ttgtgccatc cgggtctctc gcgcgagcga     60

tttagtctga ggcgaagctt cggagcggcc ggtactgttg aaagcgacaa gtggaggcgc    120

cgctctagcg gccgggactc tgaactatgg cggctagtga tacagagcga gatggactag    180

ccccagaaaa gacatcacca gatagagata agaaaaaaga gcagtcagaa gtatctgttt    240

ctcctagagc ttcaaaacat cattattcaa gatcacgatc aaggtcaaga gaaagaaaac    300

gaaagtcaga taatgaagga agaaaacaca ggagccggag cagaagcaaa gagcgtgctt    360

atgcgcgaag agactgaact gaagacgctg cagactcaga tagcaaaata ataagcctac    420

ttcatgataa gaaccaactt cttcttaaaa cagggaagaa gacatgaatc caaagataaa    480

tcctctaaga aacataagtc tgaggaacat aatgacaaag aacattcttc tgataaagga    540

agagagcgac taaattcatc tgaaaatggt gaggacaggc acaaacgcaa agaaagaaag    600

tcatcaagag gcagaagtca ctcaagatct aggtctcgtg aaagacgcca tcgtagtaga    660

agcagggagc ggaagaagtc tcgatccagg agtagggagc ggaagaaatc gagatccaga    720

agcagagaga ggaagaaatc gagatccaga agcagggaaa gaaaacggcg gatcaggtct    780

cgttcccgct caagatcaag acacaggcat aggactagaa gcaggagtag gacaaggagt    840

aggagtcgag atagaaagaa gagaattgaa aagccgagaa gatttagcag aagtttaagc    900

cggactccaa gtccacctcc cttcagaggc agaaacacag caatggatgc acaggaagct    960

ttagctagaa ggttggaaag ggcaaagaaa ttacaagaac agcgagaaaa ggaaatggtt   1020

gaaaaacaaa aacaacaaga aatagctgca gctgcagcta ctggaggttc tgttctcaat   1080

gttgctgccc tgttggcatc aggaacacaa gtaacacctc agatagccat ggcagctcag   1140

atggcagccc tgcaagctaa agctttggca gagacaggaa tagctgttcc tagctactat   1200

aacccagccg ctgttaatcc aatgaaattt gctgaacaag agaaaaaaag gaaaatgctt   1260

tggcagggca agaaagaagg ggacaaatcc caatctgctg aaatatggga aaaattgaat   1320

tttggaaaca aggaccaaaa tgtcaaattt aggaaattga tgggtattaa gagtgaagat   1380

gaagctggat gtagctcagt tgatgaagaa agttacaaga ctctgaagca gcaggaagaa   1440

gtatttcgaa atttagatgc tcagtatgaa atggcaagat cacaaaccca cacacaaaga   1500

ggaatgggtt tgggtttcac atcttcaatg cgaggaatgg atgcagtttg aaaatgatca   1560

cacttgtaaa gtttgggact tatagacttc ttgttctgat gtcacgtcct tgttcaccaa   1620

acagctagca ctctagcttg catgggtgtt gcattgactt taatttattg aaaaatacaa   1680

atttttgtaa atatcagatc agtgatactg gtgttagtgt tgtaatcagg ttaaacccac   1740

ttccattaaa cttgacagga ctatagaagg ataatatttt ttagttcatg aattctactt   1800

ttcaaatata taaaagctgc aggtggggat aaaatctcat acatggattt tttcgtgtcc   1860

gctgtcttgt gtacttttgt acttaacctt gtacagttat tttcatctct tgaaacatga   1920

aagaaatgtt atgtagatgt tctttagaag atctggccat ttggtacata atccagcaca   1980

gataagctgg gtggtaatga taataaaaat ggttttctca aaactggtgt taatttaagt   2040

tacctgggat gtttctttga atttgtttta tagtttctgt agcatttggc aattgctgtt   2100

agaaaacact agctagaaat cccctcccca ccaccctttt taaggccagt taactatact   2160

acagtcaata ccgtggtgag caaaaatgta aaaggtggaa ggagaaaact tactaaaata   2220

gtatgttttc ctattataag ggacagactt ggtattcagt atttgtcaaa tattacatgt   2280

gttattcagg agatagatta atgcattaaa gggatgtaag cacttttatt ttaataaagt   2340

gccttataac aa                                                       2352


<210>  932
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  932

Met Ile Arg Thr Asn Phe Phe Leu Lys Gln Gly Arg Arg His Glu Ser 
1               5                   10                  15


Lys Asp Lys Ser Ser Lys Lys His Lys Ser Glu Glu His Asn Asp Lys 
            20                  25                  30


Glu His Ser Ser Asp Lys Gly Arg Glu Arg Leu Asn Ser Ser Glu Asn 
        35                  40                  45


Gly Glu Asp Arg His Lys Arg Lys Glu Arg Lys Ser Ser Arg Gly Arg 
    50                  55                  60


Ser His Ser Arg Ser Arg Ser Arg Glu Arg Arg His Arg Ser Arg Ser 
65                  70                  75                  80


Arg Glu Arg Lys Lys Ser Arg Ser Arg Ser Arg Glu Arg Lys Lys Ser 
                85                  90                  95


Arg Ser Arg Ser Arg Glu Arg Lys Lys Ser Arg Ser Arg Ser Arg Glu 
            100                 105                 110


Arg Lys Arg Arg Ile Arg Ser Arg Ser Arg Ser Arg Ser Arg His Arg 
        115                 120                 125


His Arg Thr Arg Ser Arg Ser Arg Thr Arg Ser Arg Ser Arg Asp Arg 
    130                 135                 140


Lys Lys Arg Ile Glu Lys Pro Arg Arg Phe Ser Arg Ser Leu Ser Arg 
145                 150                 155                 160


Thr Pro Ser Pro Pro Pro Phe Arg Gly Arg Asn Thr Ala Met Asp Ala 
                165                 170                 175


Gln Glu Ala Leu Ala Arg Arg Leu Glu Arg Ala Lys Lys Leu Gln Glu 
            180                 185                 190


Gln Arg Glu Lys Glu Met Val Glu Lys Gln Lys Gln Gln Glu Ile Ala 
        195                 200                 205


Ala Ala Ala Ala Thr Gly Gly Ser Val Leu Asn Val Ala Ala Leu Leu 
    210                 215                 220


Ala Ser Gly Thr Gln Val Thr Pro Gln Ile Ala Met Ala Ala Gln Met 
225                 230                 235                 240


Ala Ala Leu Gln Ala Lys Ala Leu Ala Glu Thr Gly Ile Ala Val Pro 
                245                 250                 255


Ser Tyr Tyr Asn Pro Ala Ala Val Asn Pro Met Lys Phe Ala Glu Gln 
            260                 265                 270


Glu Lys Lys Arg Lys Met Leu Trp Gln Gly Lys Lys Glu Gly Asp Lys 
        275                 280                 285


Ser Gln Ser Ala Glu Ile Trp Glu Lys Leu Asn Phe Gly Asn Lys Asp 
    290                 295                 300


Gln Asn Val Lys Phe Arg Lys Leu Met Gly Ile Lys Ser Glu Asp Glu 
305                 310                 315                 320


Ala Gly Cys Ser Ser Val Asp Glu Glu Ser Tyr Lys Thr Leu Lys Gln 
                325                 330                 335


Gln Glu Glu Val Phe Arg Asn Leu Asp Ala Gln Tyr Glu Met Ala Arg 
            340                 345                 350


Ser Gln Thr His Thr Gln Arg Gly Met Gly Leu Gly Phe Thr Ser Ser 
        355                 360                 365


Met Arg Gly Met Asp Ala Val 
    370                 375


<210>  933
<211>  2331
<212>  DNA
<213>  Homo sapiens

<400>  933
aagctgtgcg acgcgccggg cctcctcgcc tttgtgccat ccgggtctct cgcgcgagcg     60

atttagtctg aggcgaagct tcggagcggc cggtactgtt gaaagcgaca agtggaggcg    120

ccgctctagc ggccgggact ctgaactatg gcggctagtg atacagagcg agatggacta    180

gccccagaaa agacatcacc agatagagat aagaaaaaag agcagtcaga agtatctgtt    240

tctcctagag cttcaaaaca tcattattca agatcacgat caaggtcaag agaaagaaaa    300

cgaaagtcag ataatgaagg aagaaaacac aggagccgga gcagaagcaa agagcgtgct    360

tatgcgcgaa gagactgaac tgaagacgct gcagactcag atagcaaaat aataagccta    420

cttcatgata agggaagaag acatgaatcc aaagataaat cctctaagaa acataagtct    480

gaggaacata atgacaaaga acattcttct gataaaggaa gagagcgact aaattcatct    540

gaaaatggtg aggacaggca caaacgcaaa gaaagaaagt catcaagagg cagaagtcac    600

tcaagatcta ggtctcgtga aagacgccat cgtagtagaa gcagggagcg gaagaagtct    660

cgatccagga gtagggagcg gaagaaatcg agatccagaa gcagagagag gaagaaatcg    720

agatccagaa gcagggaaag aaaacggcgg atcaggtctc gttcccgctc aagatcaaga    780

cacaggcata ggactagaag caggagtagg acaaggagta ggagtcgaga tagaaagaag    840

agaattgaaa agccgagaag atttagcaga agtttaagcc ggactccaag tccacctccc    900

ttcagaggca gaaacacagc aatggatgca caggaagctt tagctagaag gttggaaagg    960

gcaaagaaat tacaagaaca gcgagaaaag gaaatggttg aaaaacaaaa acaacaagaa   1020

atagctgcag ctgcagctac tggaggttct gttctcaatg ttgctgccct gttggcatca   1080

ggaacacaag taacacctca gatagccatg gcagctcaga tggcagccct gcaagctaaa   1140

gctttggcag agacaggaat agctgttcct agctactata acccagccgc tgttaatcca   1200

atgaaatttg ctgaacaaga gaaaaaaagg aaaatgcttt ggcagggcaa gaaagaaggg   1260

gacaaatccc aatctgctga aatatgggaa aaattgaatt ttggaaacaa ggaccaaaat   1320

gtcaaattta ggaaattgat gggtattaag agtgaagatg aagctggatg tagctcagtt   1380

gatgaagaaa gttacaagac tctgaagcag caggaagaag tatttcgaaa tttagatgct   1440

cagtatgaaa tggcaagatc acaaacccac acacaaagag gaatgggttt gggtttcaca   1500

tcttcaatgc gaggaatgga tgcagtttga aaatgatcac acttgtaaag tttgggactt   1560

atagacttct tgttctgatg tcacgtcctt gttcaccaaa cagctagcac tctagcttgc   1620

atgggtgttg cattgacttt aatttattga aaaatacaaa tttttgtaaa tatcagatca   1680

gtgatactgg tgttagtgtt gtaatcaggt taaacccact tccattaaac ttgacaggac   1740

tatagaagga taatattttt tagttcatga attctacttt tcaaatatat aaaagctgca   1800

ggtggggata aaatctcata catggatttt ttcgtgtccg ctgtcttgtg tacttttgta   1860

cttaaccttg tacagttatt ttcatctctt gaaacatgaa agaaatgtta tgtagatgtt   1920

ctttagaaga tctggccatt tggtacataa tccagcacag ataagctggg tggtaatgat   1980

aataaaaatg gttttctcaa aactggtgtt aatttaagtt acctgggatg tttctttgaa   2040

tttgttttat agtttctgta gcatttggca attgctgtta gaaaacacta gctagaaatc   2100

ccctccccac cacccttttt aaggccagtt aactatacta cagtcaatac cgtggtgagc   2160

aaaaatgtaa aaggtggaag gagaaaactt actaaaatag tatgttttcc tattataagg   2220

gacagacttg gtattcagta tttgtcaaat attacatgtg ttattcagga gatagattaa   2280

tgcattaaag ggatgtaagc acttttattt taataaagtg ccttataaca a            2331


<210>  934
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  934

Met Asp Ala Gln Glu Ala Leu Ala Arg Arg Leu Glu Arg Ala Lys Lys 
1               5                   10                  15


Leu Gln Glu Gln Arg Glu Lys Glu Met Val Glu Lys Gln Lys Gln Gln 
            20                  25                  30


Glu Ile Ala Ala Ala Ala Ala Thr Gly Gly Ser Val Leu Asn Val Ala 
        35                  40                  45


Ala Leu Leu Ala Ser Gly Thr Gln Val Thr Pro Gln Ile Ala Met Ala 
    50                  55                  60


Ala Gln Met Ala Ala Leu Gln Ala Lys Ala Leu Ala Glu Thr Gly Ile 
65                  70                  75                  80


Ala Val Pro Ser Tyr Tyr Asn Pro Ala Ala Val Asn Pro Met Lys Phe 
                85                  90                  95


Ala Glu Gln Glu Lys Lys Arg Lys Met Leu Trp Gln Gly Lys Lys Glu 
            100                 105                 110


Gly Asp Lys Ser Gln Ser Ala Glu Ile Trp Glu Lys Leu Asn Phe Gly 
        115                 120                 125


Asn Lys Asp Gln Asn Val Lys Phe Arg Lys Leu Met Gly Ile Lys Ser 
    130                 135                 140


Glu Asp Glu Ala Gly Cys Ser Ser Val Asp Glu Glu Ser Tyr Lys Thr 
145                 150                 155                 160


Leu Lys Gln Gln Glu Glu Val Phe Arg Asn Leu Asp Ala Gln Tyr Glu 
                165                 170                 175


Met Ala Arg Ser Gln Thr His Thr Gln Arg Gly Met Gly Leu Gly Phe 
            180                 185                 190


Thr Ser Ser Met Arg Gly Met Asp Ala Val 
        195                 200


<210>  935
<211>  6965
<212>  DNA
<213>  Homo sapiens

<400>  935
ggcatggaac ctaaagacta gaggcggttg tgtgagtcag gaagaggggc cagatatctg     60

agtgttcctc tttagtttct tcaattgcag ataatatggt gtctaatttt atgttgttca    120

ggaaagacag tggttcctga ctcaggaaga cagtctcaga aacatgtgga atgatattga    180

gctgctaaca aatgatgata ccggaagtgg gtacctgagt gtcggttcaa gaaaagaaca    240

tggaactgct ttatatcaag tagatttgct agtgaagatc tcttctgaaa aggcctcatt    300

aaatccaaag atacaggcat gcagcttaag tgatgggttt attattgtag ccgaccaatc    360

agtgatattg cttgacagta tttgtagatc acttcaattg catcttgtct ttgatactga    420

agtggatgta gttggccttt gtcaagaagg aaagtttctt ttggttggcg agagaagtgg    480

caacctacat cttattcatg taacatcaaa acaaacacta ctcactaatg catttgttca    540

gaaagctaac gatgaaaatc ggcggactta ccagaatctt gtcattgaga aggatggttc    600

aaatgaaggt acctattata tgctacttct tacatacagt ggattttttt gtattacaaa    660

ccttcagctt ttaaaaattc aacaagcaat tgagaatgta gacttcagta cagcaaaaaa    720

gttacaagga caaatcaagt ccagttttat ttctactgaa aattatcata ctcttggttg    780

tctcagtctt gtggctggag atttagcaag tgaagttcct gtgataattg ggggaaccgg    840

taattgtgca ttctcaaaat gggaaccaga ttcttccaag aaaggaatga cagttaagaa    900

ccttattgat gcagagatta ttaaaggtgc aaagaagttc cagctgatag acaatctact    960

ttttgttctt gatactgata acgtgctgag tttatgggat atttacactc taactcctgt   1020

atggaactgg ccctctcttc acgtagaaga gtttcttctt actacagaag cagactctcc   1080

ttcatcagtc acgtggcaag gaattacaaa tctcaaatta atagctctga cagcttcagc   1140

taataagaag atgaaaaacc tcatggttta ttcattacct acaatggaaa tactatattc   1200

tttggaagta tctagtgttt cttctctggt ccaaacagga attagcacag ataccatata   1260

ccttttagaa ggagtttgca aaaatgatcc aaaattgtct gaagactcag tctctgtgtt   1320

agtactcaga tgtcttacgg aagctttacc agaaaacaga ttgagtcggt tacttcacaa   1380

acacagattt gctgaagctg agagttttgc cattcagttt ggactagatg ttgagcttgt   1440

ttacaaggtc aagtcaaatc atatattgga gaaactggca ttgagttctg tggatgccag   1500

tgaacagacc gaatggcaac aacttgtaga cgacgctaag gaaaatctac ataagatcca   1560

ggatgatgaa tttgtggtga attactgcct gaaagctcag tggataacct atgaaaccac   1620

tcaagagatg ctgaattatg ccaaaaccag gcttttgaag aaagaagata aaactgctct   1680

catttattct gatggcttga aagaggtgct aagagctcat gcaaaattga ctacttttta   1740

tggagcattt ggaccagaaa aattcagtgg cagttcttgg attgaatttc taaataatga   1800

agatgatctt aaagatattt ttttacagct aaaagaagga aaccttgttt gtgcacagta   1860

tctttggctt cgacatcggg caaactttga aagcagattt gatgtgaaaa tgctggagag   1920

cttgctcaac tcaatgtctg catcagtctc tttgcaaaag ctgtgtccat ggtttaaaaa   1980

tgatgtgatt ccatttgtaa gaaggactgt gcctgaagga cagataattc ttgcaaaatg   2040

gttggaacaa gcagccagga accttgaatt aactgataag gcaaattggc cagaaaatgg   2100

acttcaattg gcagagatat tttttacagc agaaaaaaca gacgagttgg gattggcatc   2160

ttcctggcat tggatttcct tgaaagatta tcagaacaca gaggaagtat gtcagctaag   2220

gactttggta aataacttgc gagagttgat cacgttgcat aggaagtaca actgcaaatt   2280

agccctctct gattttgaga aggaaaatac aaccaccata gtgttccgaa tgtttgataa   2340

agtgctggcc ccagagctta ttccctccat cttagagaag tttataagag tttacatgag   2400

agaacatgac ttgcaagagg aggaacttct cttgctgtac atagaggatt tactgaatag   2460

atgcagctca aagtccacat cactctttga aacagcatgg gaagcaaagg ccatggcagt   2520

aatagcgtgt ttatctgaca cggacctcat atttgatgcc gtgctcaaga tcatgtatgc   2580

ggcagtggtt ccttggagtg cagctgtgga gcaactggtg aaacagcacc tggaaatgga   2640

ccatcccaaa gtcaagttat tacaggaaag ttacaaacta atggagatga aaaaactttt   2700

acgaggctat ggaataagag aggtaaatct cttaaacaag gaaataatga gagtggttag   2760

atacattctc aaacaagatg tcccatcttc tttagaagat gctttaaagg tagcccaagc   2820

gtttatgtta tctgatgatg agatctacag tctaagaatt attgacctga ttgatagaga   2880

acagggtgaa gactgtctcc ttctgttgaa gtctttgcct cctgctgaag ctgagaaaac   2940

tgcagaaaga gtcatcatat gggcacgact ggcattacaa gaagagccag atcattctaa   3000

agagggcaag gcctggagaa tgtctgtagc gaagacatcc gtggacattc ttaagatact   3060

atgtgacatt cagaaagaca atctgcagaa gaaggacgaa tgtgaagaaa tgttgaaact   3120

atttaaagag gttgctagct tacaggagaa ctttgaggtc tttctttcat ttgaagatta   3180

tagcaatagt tccctggtag cagatctccg tgagcagcac attaaagctc acgaagttgc   3240

acaggcgaaa cacaaacctg ggagcacccc agagcccata gctgctgagg tgaggagccc   3300

aagcatggaa tcaaagctgc acagacaggc actggccctg cagatgtcca aacaagagct   3360

ggaggcagag ctgaccttga gagccttaaa agatgggaac atcaaaacag cactgaaaaa   3420

atgcagcgac ttgtttaagt atcactgcaa tgctgacact gggaaattgc tatttctgac   3480

atgtcagaag ctttgtcaga tgttggctga taatgtccca gtgacagtgc ctgtgggact   3540

gaatcttcct tccatgatac atgatctagc aagccaagct gccaccattt gcagtccaga   3600

ttttttacta gatgctttag aactatgtaa acatacttta atggctgtag agctttccag   3660

acaatgccaa atggatgact gtggaatcct catgaaagct tcttttggga cacataaaga   3720

tccatatgaa gagtggtctt acagtgactt cttcagtgaa gatggaattg ttcttgagtc   3780

acagatggtg cttccagtga tttatgaact gatttcatct cttgtgcctc tagctgaaag   3840

caagagatat cccttggagt ctaccagttt gccatactgc tcccttaatg aaggagatgg   3900

ccttgtttta cctgttataa attccatctc tgccctgctt cagaatcttc aggaatctag   3960

ccagtgggag ctagccctaa gatttgtggt tggttcattt ggtacctgtc ttcagcactc   4020

tgtgtcaaac ttcatgaatg ccactttgag tgaaaagtta tttggagaga ctacattagt   4080

taaatcaagg catgttgtta tggaattgaa agaaaaagct gttatattta tcagggaaaa   4140

tgctacaaca ctactgcaca aagtatttaa ttgtcgcttg gtagatcttg acctggcgtt   4200

gggttactgc actctcttac ctcaaaaaga tgtgtttgaa aatctctgga agctcataga   4260

taaagcatgg cagaattacg acaaaatctt ggcaatatct ctggtgggct ctgagctggc   4320

aagtctctat caggaaatag aaatggggct taagttccgt gaactcagta ctgatgccca   4380

gtggggcatt cgtcttggta aacttggtat ttcttttcaa ccagttttca ggcaacattt   4440

tctcaccaag aaagacctca ttaaagctct tgtggagaat atagatatgg acacaagcct   4500

cattttggaa tattgcagca catttcagtt ggactgcgat gcagttcttc agctcttcat   4560

tgaaacgctg ctccacaaca caaatgccgg ccaaggccag ggagatgcaa gcatggactc   4620

tgcaaagcgg cggcatccca aactcctggc caaagccctt gagatggttc ctttactgac   4680

gagcacaaaa gatttggtca tcagtcttag tggaatacta cataagttgg atccttatga   4740

ctatgaaatg attgaagttg tcttgaaagt tatagaacga gctgatgaaa agataaccaa   4800

tattaatatt aatcaggcat tgagtattct gaaacatttg aagtcataca gaagaatttc   4860

tcctcccgtg gatctagaat atcagtatat gttggaacat gtcataactt tgccatcagc   4920

tgcccaaact agactgcctt ttcacctgat attctttggc acagcacaga acttctggaa   4980

aattctctct acagaactca gtgaagaatc tttcccaaca ttgctcttaa tttcgaaatt   5040

aatgaagttc tctctggaca ctctgtacgt gtctacagca aaacacgttt tcgaaaaaaa   5100

actgaagcca aagctcctga agttaacaca agctaaatcc tcaacactga ttaacaagga   5160

aataactaag atcacgcaga ccatcgaatc ctgcttactc tctatagtca acccagagtg   5220

ggctgtagct attgccatca gccttgccca ggatatccct gaaggttcct tcaagatatc   5280

tgctttgaaa ttctgccttt atttagctga gagatggcta cagaatatcc catcgcagga   5340

cgaaaaacgt gaaaaagccg aggctttgtt gaagaagctt catatccagt accggcgatc   5400

gggcacagaa gctgtgctca tagcccacaa gctgaacact gaggaatatt taagagtgat   5460

cggaaagcca gcacatctta ttgtcagtct ctacgaacat cctagcatca atcaaagaat   5520

tcagaattca tctggcacag attatcctga tattcatgca gcagctaaag aaatagccga   5580

agtcaatgaa attaatttgg aaaaagtctg ggacatgttg ttggaaaaat ggctatgccc   5640

ttcaacaaaa cctggtgaaa aaccatcaga attatttgaa cttcaagaag atgaagccct   5700

acgaagagtg cagtatctcc tcctgtctcg tccaattgat tatagttcaa gaatgctgtt   5760

tgtatttgca acatcaacta caaccacatt aggtatgcat cagttaactt ttgcccatag   5820

aactcgagct cttcagtgtc tcttctattt ggctgacaag gaaactatag aatctctctt   5880

taaaaaaccc attgaagaag tgaaatctta tttgagatgt ataacttttc tggcatcatt   5940

tgagactttg aatatcccca tcacatatga attattttgc agcagtccta aagaaggaat   6000

gattaagggt ctgtggaaaa accacagcca cgagtccatg gcagtaagat tggtgactga   6060

gctgtgttta gaatacaaaa tctatgacct gcagctttgg aatggactct tgcaaaagct   6120

tctgggcttc aatatgattc cttatctaag gaaagtttta aaagccatct ccagtatcca   6180

ttctttatgg caggttccct acttcagcaa agcgtggcag cgtgtgatac agataccact   6240

gctttcagcc tcttgtcctt taagtcctga tcagctgtca gattgttctg agagtctcat   6300

cgctgtcctc gaatgtccag tctcaggtga tcttgacctg atcggagtcg ccaggcagta   6360

tatccagtta gaacttccgg cttttgcatt agcttgtctg atgctcatgc cccactcaga   6420

gaaaagacac cagcaaatta agaattttct gggttcctgt gaccctcagg ttattttaaa   6480

gcaattggaa gagcatatga acacgggcca gctagcagga ttttcacatc aaattagaag   6540

tctgattttg aataatatca tcaataagaa ggagtttggg attttggcaa agaccaaata   6600

ctttcaaatg ttgaagatgc atgcgatgaa taccaacaat atcactgagc tagtgaacta   6660

tttggcaaat gacttaagtt tagatgaagc ttcagtcttg ataactgaat attcaaagca   6720

ctgcgggaaa cctgtgcctc cagacactgc tccctgtgaa attctgaaga tgtttcttag   6780

tggattatcg taaatcactg aacctttttt tcaagaagga caagaatttt ggagtctgct   6840

attaatggac catatttatt acagttttta aattgtacaa tctctgtatt atagctattt   6900

gtctaacatt accccacatg taataaataa aacaatatga gcataattgc cccataaaga   6960

actca                                                               6965


<210>  936
<211>  2209
<212>  PRT
<213>  Homo sapiens

<400>  936

Met Trp Asn Asp Ile Glu Leu Leu Thr Asn Asp Asp Thr Gly Ser Gly 
1               5                   10                  15


Tyr Leu Ser Val Gly Ser Arg Lys Glu His Gly Thr Ala Leu Tyr Gln 
            20                  25                  30


Val Asp Leu Leu Val Lys Ile Ser Ser Glu Lys Ala Ser Leu Asn Pro 
        35                  40                  45


Lys Ile Gln Ala Cys Ser Leu Ser Asp Gly Phe Ile Ile Val Ala Asp 
    50                  55                  60


Gln Ser Val Ile Leu Leu Asp Ser Ile Cys Arg Ser Leu Gln Leu His 
65                  70                  75                  80


Leu Val Phe Asp Thr Glu Val Asp Val Val Gly Leu Cys Gln Glu Gly 
                85                  90                  95


Lys Phe Leu Leu Val Gly Glu Arg Ser Gly Asn Leu His Leu Ile His 
            100                 105                 110


Val Thr Ser Lys Gln Thr Leu Leu Thr Asn Ala Phe Val Gln Lys Ala 
        115                 120                 125


Asn Asp Glu Asn Arg Arg Thr Tyr Gln Asn Leu Val Ile Glu Lys Asp 
    130                 135                 140


Gly Ser Asn Glu Gly Thr Tyr Tyr Met Leu Leu Leu Thr Tyr Ser Gly 
145                 150                 155                 160


Phe Phe Cys Ile Thr Asn Leu Gln Leu Leu Lys Ile Gln Gln Ala Ile 
                165                 170                 175


Glu Asn Val Asp Phe Ser Thr Ala Lys Lys Leu Gln Gly Gln Ile Lys 
            180                 185                 190


Ser Ser Phe Ile Ser Thr Glu Asn Tyr His Thr Leu Gly Cys Leu Ser 
        195                 200                 205


Leu Val Ala Gly Asp Leu Ala Ser Glu Val Pro Val Ile Ile Gly Gly 
    210                 215                 220


Thr Gly Asn Cys Ala Phe Ser Lys Trp Glu Pro Asp Ser Ser Lys Lys 
225                 230                 235                 240


Gly Met Thr Val Lys Asn Leu Ile Asp Ala Glu Ile Ile Lys Gly Ala 
                245                 250                 255


Lys Lys Phe Gln Leu Ile Asp Asn Leu Leu Phe Val Leu Asp Thr Asp 
            260                 265                 270


Asn Val Leu Ser Leu Trp Asp Ile Tyr Thr Leu Thr Pro Val Trp Asn 
        275                 280                 285


Trp Pro Ser Leu His Val Glu Glu Phe Leu Leu Thr Thr Glu Ala Asp 
    290                 295                 300


Ser Pro Ser Ser Val Thr Trp Gln Gly Ile Thr Asn Leu Lys Leu Ile 
305                 310                 315                 320


Ala Leu Thr Ala Ser Ala Asn Lys Lys Met Lys Asn Leu Met Val Tyr 
                325                 330                 335


Ser Leu Pro Thr Met Glu Ile Leu Tyr Ser Leu Glu Val Ser Ser Val 
            340                 345                 350


Ser Ser Leu Val Gln Thr Gly Ile Ser Thr Asp Thr Ile Tyr Leu Leu 
        355                 360                 365


Glu Gly Val Cys Lys Asn Asp Pro Lys Leu Ser Glu Asp Ser Val Ser 
    370                 375                 380


Val Leu Val Leu Arg Cys Leu Thr Glu Ala Leu Pro Glu Asn Arg Leu 
385                 390                 395                 400


Ser Arg Leu Leu His Lys His Arg Phe Ala Glu Ala Glu Ser Phe Ala 
                405                 410                 415


Ile Gln Phe Gly Leu Asp Val Glu Leu Val Tyr Lys Val Lys Ser Asn 
            420                 425                 430


His Ile Leu Glu Lys Leu Ala Leu Ser Ser Val Asp Ala Ser Glu Gln 
        435                 440                 445


Thr Glu Trp Gln Gln Leu Val Asp Asp Ala Lys Glu Asn Leu His Lys 
    450                 455                 460


Ile Gln Asp Asp Glu Phe Val Val Asn Tyr Cys Leu Lys Ala Gln Trp 
465                 470                 475                 480


Ile Thr Tyr Glu Thr Thr Gln Glu Met Leu Asn Tyr Ala Lys Thr Arg 
                485                 490                 495


Leu Leu Lys Lys Glu Asp Lys Thr Ala Leu Ile Tyr Ser Asp Gly Leu 
            500                 505                 510


Lys Glu Val Leu Arg Ala His Ala Lys Leu Thr Thr Phe Tyr Gly Ala 
        515                 520                 525


Phe Gly Pro Glu Lys Phe Ser Gly Ser Ser Trp Ile Glu Phe Leu Asn 
    530                 535                 540


Asn Glu Asp Asp Leu Lys Asp Ile Phe Leu Gln Leu Lys Glu Gly Asn 
545                 550                 555                 560


Leu Val Cys Ala Gln Tyr Leu Trp Leu Arg His Arg Ala Asn Phe Glu 
                565                 570                 575


Ser Arg Phe Asp Val Lys Met Leu Glu Ser Leu Leu Asn Ser Met Ser 
            580                 585                 590


Ala Ser Val Ser Leu Gln Lys Leu Cys Pro Trp Phe Lys Asn Asp Val 
        595                 600                 605


Ile Pro Phe Val Arg Arg Thr Val Pro Glu Gly Gln Ile Ile Leu Ala 
    610                 615                 620


Lys Trp Leu Glu Gln Ala Ala Arg Asn Leu Glu Leu Thr Asp Lys Ala 
625                 630                 635                 640


Asn Trp Pro Glu Asn Gly Leu Gln Leu Ala Glu Ile Phe Phe Thr Ala 
                645                 650                 655


Glu Lys Thr Asp Glu Leu Gly Leu Ala Ser Ser Trp His Trp Ile Ser 
            660                 665                 670


Leu Lys Asp Tyr Gln Asn Thr Glu Glu Val Cys Gln Leu Arg Thr Leu 
        675                 680                 685


Val Asn Asn Leu Arg Glu Leu Ile Thr Leu His Arg Lys Tyr Asn Cys 
    690                 695                 700


Lys Leu Ala Leu Ser Asp Phe Glu Lys Glu Asn Thr Thr Thr Ile Val 
705                 710                 715                 720


Phe Arg Met Phe Asp Lys Val Leu Ala Pro Glu Leu Ile Pro Ser Ile 
                725                 730                 735


Leu Glu Lys Phe Ile Arg Val Tyr Met Arg Glu His Asp Leu Gln Glu 
            740                 745                 750


Glu Glu Leu Leu Leu Leu Tyr Ile Glu Asp Leu Leu Asn Arg Cys Ser 
        755                 760                 765


Ser Lys Ser Thr Ser Leu Phe Glu Thr Ala Trp Glu Ala Lys Ala Met 
    770                 775                 780


Ala Val Ile Ala Cys Leu Ser Asp Thr Asp Leu Ile Phe Asp Ala Val 
785                 790                 795                 800


Leu Lys Ile Met Tyr Ala Ala Val Val Pro Trp Ser Ala Ala Val Glu 
                805                 810                 815


Gln Leu Val Lys Gln His Leu Glu Met Asp His Pro Lys Val Lys Leu 
            820                 825                 830


Leu Gln Glu Ser Tyr Lys Leu Met Glu Met Lys Lys Leu Leu Arg Gly 
        835                 840                 845


Tyr Gly Ile Arg Glu Val Asn Leu Leu Asn Lys Glu Ile Met Arg Val 
    850                 855                 860


Val Arg Tyr Ile Leu Lys Gln Asp Val Pro Ser Ser Leu Glu Asp Ala 
865                 870                 875                 880


Leu Lys Val Ala Gln Ala Phe Met Leu Ser Asp Asp Glu Ile Tyr Ser 
                885                 890                 895


Leu Arg Ile Ile Asp Leu Ile Asp Arg Glu Gln Gly Glu Asp Cys Leu 
            900                 905                 910


Leu Leu Leu Lys Ser Leu Pro Pro Ala Glu Ala Glu Lys Thr Ala Glu 
        915                 920                 925


Arg Val Ile Ile Trp Ala Arg Leu Ala Leu Gln Glu Glu Pro Asp His 
    930                 935                 940


Ser Lys Glu Gly Lys Ala Trp Arg Met Ser Val Ala Lys Thr Ser Val 
945                 950                 955                 960


Asp Ile Leu Lys Ile Leu Cys Asp Ile Gln Lys Asp Asn Leu Gln Lys 
                965                 970                 975


Lys Asp Glu Cys Glu Glu Met Leu Lys Leu Phe Lys Glu Val Ala Ser 
            980                 985                 990


Leu Gln Glu Asn Phe Glu Val Phe Leu Ser Phe Glu Asp Tyr Ser Asn 
        995                 1000                1005


Ser Ser Leu Val Ala Asp Leu Arg Glu Gln His Ile Lys Ala His Glu 
    1010                1015                1020


Val Ala Gln Ala Lys His Lys Pro Gly Ser Thr Pro Glu Pro Ile Ala 
1025                1030                1035                1040


Ala Glu Val Arg Ser Pro Ser Met Glu Ser Lys Leu His Arg Gln Ala 
                1045                1050                1055


Leu Ala Leu Gln Met Ser Lys Gln Glu Leu Glu Ala Glu Leu Thr Leu 
            1060                1065                1070


Arg Ala Leu Lys Asp Gly Asn Ile Lys Thr Ala Leu Lys Lys Cys Ser 
        1075                1080                1085


Asp Leu Phe Lys Tyr His Cys Asn Ala Asp Thr Gly Lys Leu Leu Phe 
    1090                1095                1100


Leu Thr Cys Gln Lys Leu Cys Gln Met Leu Ala Asp Asn Val Pro Val 
1105                1110                1115                1120


Thr Val Pro Val Gly Leu Asn Leu Pro Ser Met Ile His Asp Leu Ala 
                1125                1130                1135


Ser Gln Ala Ala Thr Ile Cys Ser Pro Asp Phe Leu Leu Asp Ala Leu 
            1140                1145                1150


Glu Leu Cys Lys His Thr Leu Met Ala Val Glu Leu Ser Arg Gln Cys 
        1155                1160                1165


Gln Met Asp Asp Cys Gly Ile Leu Met Lys Ala Ser Phe Gly Thr His 
    1170                1175                1180


Lys Asp Pro Tyr Glu Glu Trp Ser Tyr Ser Asp Phe Phe Ser Glu Asp 
1185                1190                1195                1200


Gly Ile Val Leu Glu Ser Gln Met Val Leu Pro Val Ile Tyr Glu Leu 
                1205                1210                1215


Ile Ser Ser Leu Val Pro Leu Ala Glu Ser Lys Arg Tyr Pro Leu Glu 
            1220                1225                1230


Ser Thr Ser Leu Pro Tyr Cys Ser Leu Asn Glu Gly Asp Gly Leu Val 
        1235                1240                1245


Leu Pro Val Ile Asn Ser Ile Ser Ala Leu Leu Gln Asn Leu Gln Glu 
    1250                1255                1260


Ser Ser Gln Trp Glu Leu Ala Leu Arg Phe Val Val Gly Ser Phe Gly 
1265                1270                1275                1280


Thr Cys Leu Gln His Ser Val Ser Asn Phe Met Asn Ala Thr Leu Ser 
                1285                1290                1295


Glu Lys Leu Phe Gly Glu Thr Thr Leu Val Lys Ser Arg His Val Val 
            1300                1305                1310


Met Glu Leu Lys Glu Lys Ala Val Ile Phe Ile Arg Glu Asn Ala Thr 
        1315                1320                1325


Thr Leu Leu His Lys Val Phe Asn Cys Arg Leu Val Asp Leu Asp Leu 
    1330                1335                1340


Ala Leu Gly Tyr Cys Thr Leu Leu Pro Gln Lys Asp Val Phe Glu Asn 
1345                1350                1355                1360


Leu Trp Lys Leu Ile Asp Lys Ala Trp Gln Asn Tyr Asp Lys Ile Leu 
                1365                1370                1375


Ala Ile Ser Leu Val Gly Ser Glu Leu Ala Ser Leu Tyr Gln Glu Ile 
            1380                1385                1390


Glu Met Gly Leu Lys Phe Arg Glu Leu Ser Thr Asp Ala Gln Trp Gly 
        1395                1400                1405


Ile Arg Leu Gly Lys Leu Gly Ile Ser Phe Gln Pro Val Phe Arg Gln 
    1410                1415                1420


His Phe Leu Thr Lys Lys Asp Leu Ile Lys Ala Leu Val Glu Asn Ile 
1425                1430                1435                1440


Asp Met Asp Thr Ser Leu Ile Leu Glu Tyr Cys Ser Thr Phe Gln Leu 
                1445                1450                1455


Asp Cys Asp Ala Val Leu Gln Leu Phe Ile Glu Thr Leu Leu His Asn 
            1460                1465                1470


Thr Asn Ala Gly Gln Gly Gln Gly Asp Ala Ser Met Asp Ser Ala Lys 
        1475                1480                1485


Arg Arg His Pro Lys Leu Leu Ala Lys Ala Leu Glu Met Val Pro Leu 
    1490                1495                1500


Leu Thr Ser Thr Lys Asp Leu Val Ile Ser Leu Ser Gly Ile Leu His 
1505                1510                1515                1520


Lys Leu Asp Pro Tyr Asp Tyr Glu Met Ile Glu Val Val Leu Lys Val 
                1525                1530                1535


Ile Glu Arg Ala Asp Glu Lys Ile Thr Asn Ile Asn Ile Asn Gln Ala 
            1540                1545                1550


Leu Ser Ile Leu Lys His Leu Lys Ser Tyr Arg Arg Ile Ser Pro Pro 
        1555                1560                1565


Val Asp Leu Glu Tyr Gln Tyr Met Leu Glu His Val Ile Thr Leu Pro 
    1570                1575                1580


Ser Ala Ala Gln Thr Arg Leu Pro Phe His Leu Ile Phe Phe Gly Thr 
1585                1590                1595                1600


Ala Gln Asn Phe Trp Lys Ile Leu Ser Thr Glu Leu Ser Glu Glu Ser 
                1605                1610                1615


Phe Pro Thr Leu Leu Leu Ile Ser Lys Leu Met Lys Phe Ser Leu Asp 
            1620                1625                1630


Thr Leu Tyr Val Ser Thr Ala Lys His Val Phe Glu Lys Lys Leu Lys 
        1635                1640                1645


Pro Lys Leu Leu Lys Leu Thr Gln Ala Lys Ser Ser Thr Leu Ile Asn 
    1650                1655                1660


Lys Glu Ile Thr Lys Ile Thr Gln Thr Ile Glu Ser Cys Leu Leu Ser 
1665                1670                1675                1680


Ile Val Asn Pro Glu Trp Ala Val Ala Ile Ala Ile Ser Leu Ala Gln 
                1685                1690                1695


Asp Ile Pro Glu Gly Ser Phe Lys Ile Ser Ala Leu Lys Phe Cys Leu 
            1700                1705                1710


Tyr Leu Ala Glu Arg Trp Leu Gln Asn Ile Pro Ser Gln Asp Glu Lys 
        1715                1720                1725


Arg Glu Lys Ala Glu Ala Leu Leu Lys Lys Leu His Ile Gln Tyr Arg 
    1730                1735                1740


Arg Ser Gly Thr Glu Ala Val Leu Ile Ala His Lys Leu Asn Thr Glu 
1745                1750                1755                1760


Glu Tyr Leu Arg Val Ile Gly Lys Pro Ala His Leu Ile Val Ser Leu 
                1765                1770                1775


Tyr Glu His Pro Ser Ile Asn Gln Arg Ile Gln Asn Ser Ser Gly Thr 
            1780                1785                1790


Asp Tyr Pro Asp Ile His Ala Ala Ala Lys Glu Ile Ala Glu Val Asn 
        1795                1800                1805


Glu Ile Asn Leu Glu Lys Val Trp Asp Met Leu Leu Glu Lys Trp Leu 
    1810                1815                1820


Cys Pro Ser Thr Lys Pro Gly Glu Lys Pro Ser Glu Leu Phe Glu Leu 
1825                1830                1835                1840


Gln Glu Asp Glu Ala Leu Arg Arg Val Gln Tyr Leu Leu Leu Ser Arg 
                1845                1850                1855


Pro Ile Asp Tyr Ser Ser Arg Met Leu Phe Val Phe Ala Thr Ser Thr 
            1860                1865                1870


Thr Thr Thr Leu Gly Met His Gln Leu Thr Phe Ala His Arg Thr Arg 
        1875                1880                1885


Ala Leu Gln Cys Leu Phe Tyr Leu Ala Asp Lys Glu Thr Ile Glu Ser 
    1890                1895                1900


Leu Phe Lys Lys Pro Ile Glu Glu Val Lys Ser Tyr Leu Arg Cys Ile 
1905                1910                1915                1920


Thr Phe Leu Ala Ser Phe Glu Thr Leu Asn Ile Pro Ile Thr Tyr Glu 
                1925                1930                1935


Leu Phe Cys Ser Ser Pro Lys Glu Gly Met Ile Lys Gly Leu Trp Lys 
            1940                1945                1950


Asn His Ser His Glu Ser Met Ala Val Arg Leu Val Thr Glu Leu Cys 
        1955                1960                1965


Leu Glu Tyr Lys Ile Tyr Asp Leu Gln Leu Trp Asn Gly Leu Leu Gln 
    1970                1975                1980


Lys Leu Leu Gly Phe Asn Met Ile Pro Tyr Leu Arg Lys Val Leu Lys 
1985                1990                1995                2000


Ala Ile Ser Ser Ile His Ser Leu Trp Gln Val Pro Tyr Phe Ser Lys 
                2005                2010                2015


Ala Trp Gln Arg Val Ile Gln Ile Pro Leu Leu Ser Ala Ser Cys Pro 
            2020                2025                2030


Leu Ser Pro Asp Gln Leu Ser Asp Cys Ser Glu Ser Leu Ile Ala Val 
        2035                2040                2045


Leu Glu Cys Pro Val Ser Gly Asp Leu Asp Leu Ile Gly Val Ala Arg 
    2050                2055                2060


Gln Tyr Ile Gln Leu Glu Leu Pro Ala Phe Ala Leu Ala Cys Leu Met 
2065                2070                2075                2080


Leu Met Pro His Ser Glu Lys Arg His Gln Gln Ile Lys Asn Phe Leu 
                2085                2090                2095


Gly Ser Cys Asp Pro Gln Val Ile Leu Lys Gln Leu Glu Glu His Met 
            2100                2105                2110


Asn Thr Gly Gln Leu Ala Gly Phe Ser His Gln Ile Arg Ser Leu Ile 
        2115                2120                2125


Leu Asn Asn Ile Ile Asn Lys Lys Glu Phe Gly Ile Leu Ala Lys Thr 
    2130                2135                2140


Lys Tyr Phe Gln Met Leu Lys Met His Ala Met Asn Thr Asn Asn Ile 
2145                2150                2155                2160


Thr Glu Leu Val Asn Tyr Leu Ala Asn Asp Leu Ser Leu Asp Glu Ala 
                2165                2170                2175


Ser Val Leu Ile Thr Glu Tyr Ser Lys His Cys Gly Lys Pro Val Pro 
            2180                2185                2190


Pro Asp Thr Ala Pro Cys Glu Ile Leu Lys Met Phe Leu Ser Gly Leu 
        2195                2200                2205


Ser 



<210>  937
<211>  14805
<212>  DNA
<213>  Homo sapiens

<400>  937
gtcgatttgg tcagacaacg ccaccacttg ttgattttct caaggacatt ttgagaagat     60

atccagaagg aggacagatt cttaaggaat taattcagaa tgcagaagat gctggggcga    120

cagaagttaa atttttatat gatgaaactc aatacggaac agagactctt tggtcaaaag    180

atatggcgcc atatcagggg ccagctctct atgtgtacaa caacgcggtt ttcaccccag    240

aggactggca cggcattcaa gaaatagcaa gaagcaggaa aaaggatgat cctctgaagg    300

tcggaagatt tggaattggg tttaattctg tctatcatat aacagatgtt ccttgtatct    360

ttagtggtga ccaaatcggg atgctagatc ctcatcaaac actttttggc ccacatgaat    420

caggccaatg ttggaatctc aaagatgaca gcaaagaaat tagtgaactt tcagaccagt    480

ttgcaccatt tgttggcatt tttggaagca ccaaggaaac atttataaac ggcaattttc    540

caggaacatt tttccgtttc cctcttcgcc tacaaccttc acaacttagt agtaacctct    600

acaataagca gaaggttctt gagttgtttg agtcttttag ggcagatgca gacacagtgc    660

tgctctttct gaaaagtgtg caggatgttt ccttatatgt ccgagaggct gacggaacag    720

agaaactggt gtttagagtg acttcgagtg agagtaaggc actgaaacat gagcggccga    780

attctataaa gattctggga actgctataa gtaactattg taaaaagact ccaagcaata    840

acatcacctg tgtaacatat cacgtaaata ttgttttaga agaggagagt actaaggatg    900

cacagaaaac atcttggttg gtgtgtaaca gtgtgggtgg gcgagggatc agtagtaagc    960

ttgactcttt agctgatgaa ctgaaatttg tcccaatcat tggaatagcc atgcctttat   1020

caagcagaga tgatgaagca aaaggagcaa cgtctgattt ctcaggaaaa gcattttgtt   1080

tccttccttt accacctggt gaggaaagca gcacaggcct cccagttcac atcagtgggt   1140

tctttggcct tactgataac cgcaggagca taaaatggag agagctggac cagtggagag   1200

acccggcagc cttatggaat gagtttcttg tcatgaatgt tgtccccaaa gcttatgcta   1260

ctctgatctt agattcaata aaacgtctgg agatggaaaa gagctctgat ttccccttgt   1320

cagttgatgt tatctataag ctttggccgg aggcgagcaa agtcaaggtg cactggcaac   1380

cggtgttaga gcctctattc agcgagctgt tgcagaatgc agtgatttat tcaattagct   1440

gtgactgggt caggttggag caggtgtact tctcagaact tgatgaaaat ttagaataca   1500

caaaaactgt gctcaactac ctccagagct cagggaagca gattgccaag gtaccaggga   1560

atgtggatgc tgctgttcag ctcacagctg cctctggcac aacacctgtg aggaaggtga   1620

cgcccgcgtg ggtgcggcag gtgctgcgga agtgtgcaca cctgggctgt gctgaagaaa   1680

agcttcacct tctagaattt gtgctttctg accaagccta cagtgagctg cttgggctgg   1740

agctgctccc tttacaaaat ggcaattttg tccccttctc ctcatctgta tcagaccaag   1800

atgtcattta tattacctca gcagaatatc caaggtccct tttcccaagt cttgaaggaa   1860

gatttatttt ggataacttg aaacctcacc ttgtggctgc tttaaaggaa gctgcccaaa   1920

cccgaggaag accatgtact cagctgcagc ttctaaatcc agaacgattt gcacgtctta   1980

tcaaggaagt aatgaataca ttctggcctg gcagagaatt gattgttcaa tggtatccat   2040

ttgatgaaaa cagaaatcac ccatctgttt catggcttaa gatggtttgg aaaaatcttt   2100

atatacattt ttcagaggat ttgactttat ttgatgagat gccacttatc cccagaacta   2160

tactagagga aggtcagaca tgtgtggaac tcattagact caggattcca tcgttagtca   2220

ttttagacga tgaatctgaa gcacagcttc cagaattttt agcagacatt gtacaaaaac   2280

ttggagggtt tgtccttaaa aaattagatg catctataca acatccgctt attaaaaaat   2340

atattcattc accattacca agtgctgttt tgcagataat ggagaagatg ccattgcaga   2400

aattgtgtaa tcaaataact tcgctacttc caacacacaa agatgccctg aggaagttct   2460

tggctagttt aaccgatagc agtgagaaag agaaaagaat tattcaagaa ttggcaatat   2520

tcaagcgcat taaccattct tctgatcagg gaatttcctc ttatacaaaa ttgaaaggtt   2580

gtaaagtctt acaccatact gccaaactcc cagcagatct gcgactttct atttcagtaa   2640

tagacagtag tgatgaagct actattcgtc tggcaaacat gttgaaaata gaacagttaa   2700

agaccactag ctgcttaaag cttgttttaa aagatattga aaatgcattt tattcacatg   2760

aagaggtaac acagcttatg ttatgggtcc ttgagaatct atcttctctt aaaaatgaga   2820

atccaaatgt gcttgagtgg ttaacaccat taaaattcat ccagatatca caggaacaga   2880

tggtatcagc tggtgaactc tttgaccctg atatagaagt actaaaggat ctcttttgta   2940

atgaagaagg aacctatttc ccaccctcag tttttacctc accagatatt cttcactcct   3000

taagacagat tggtttaaaa aacgaagcca gtctcaaaga aaaggatgtt gtgcaagtgg   3060

caaaaaaaat tgaagcctta caggtcggtg cttgtcctga tcaagatgtt cttctgaaga   3120

aagccaaaac cctcttactg gttttaaata agaatcacac actgttgcaa tcatctgaag   3180

gaaagatgac attgaagaaa ataaaatggg ttccagcctg caaggaaagg cctccaaatt   3240

atccaggctc tttggtctgg aaaggagatc tctgtaatct ctgtgcacca ccagatatgt   3300

gtgatgtagg ccatgcaatt ctcattggct cctcacttcc tcttgttgaa agtatccatg   3360

taaacctgga aaaagcatta gggatcttca caaaacctag ccttagtgct gtcttaaaac   3420

actttaaaat tgttgttgat tggtattctt caaaaacctt tagtgatgaa gactactatc   3480

aattccagca tattttgctt gagatttacg gattcatgca tgatcatcta aatgaaggga   3540

aagattcttt tagagcctta aaatttccat gggtttggac tggcaaaaag ttttgtccac   3600

ttgcccaggc tgtgattaaa ccaatccatg atcttgacct tcagccttat ttgcataatg   3660

tacctaaaac catggcaaaa ttccaccaac tatttaaggt ctgtggttca atagaggagt   3720

tgacatcaga tcatatttcc atggttattc agaagatata tctcaaaagt gaccaagatc   3780

tcagtgaaca agaaagcaaa caaaatcttc atcttatgtt gaatattatc agatggctgt   3840

atagcaatca gattccagca agccccaaca caccagttcc tatacatcat agcaaaaatc   3900

cttctaaact tatcatgaag ccaattcacg aatgctgtta ttgtgacatt aaagttgatg   3960

accttaatga cttacttgaa gattctgtgg aaccaatcat tttggtgcat gaggacatac   4020

ccatgaaaac tgcagaatgg ctaaaagttc catgccttag tacaagactg ataaatcctg   4080

aaaacatggg atttgagcag tcaggacaaa gagagccact tactgtaaga attaaaaata   4140

ttctggaaga atacccttca gtgtcagata tttttaaaga actacttcaa aacgctgatg   4200

atgcaaatgc aacagaatgc agtttcttga ttgatatgag aagaaatatg gacataagag   4260

agaatctcct agacccaggg atggcagctt gtcatggacc tgctttgtgg tcattcaaca   4320

attctcaatt ctcagattca gattttgtga acataactag gttaggagaa tctttaaaaa   4380

ggggagaagt tgacaaagtt ggaaaatttg gtcttggatt taattctgtg taccatatca   4440

ctgacattcc catcattatg agtcgggaat tcatgataat gttcgatcca aacataaatc   4500

atatcagtaa acacattaaa gacaaatcca atcctgggat caaaattaat tggagtaaac   4560

aacagaaaag acttagaaaa tttcctaatc agttcaaacc atttatagat gtatttggct   4620

gtcagttacc tttgactgta gaagcacctt acagctataa tggaaccctt ttccgactgt   4680

cctttagaac tcaacaggaa gcaaaagtga gtgaagttag tagtacgtgc tacaatacag   4740

cagatattta ttctcttgtg gatgaattta gtctctgtgg acacaggctt atcattttca   4800

ctcagagtgt aaagtcaatg tatttgaagt acttgaaaat tgaggaaacc aaccccagtt   4860

tagcacaaga tacagtaata attaaaaaaa aatcctgctc ttccaaagca ttgaacacac   4920

ctgtcttaag tgttttaaaa gaggctgcta agctcatgaa gacttgcagc agcagtaata   4980

aaaagcttcc cagtgatgaa ccaaagtcat cttgcattct tcagatcaca gtggaagaat   5040

ttcaccatgt gttcagaagg attgctgatt tacagtcgcc actttttaga ggtccagatg   5100

atgacccagc tgctctcttt gaaatggcta agtctggcca atcaaaaaag ccatcagatg   5160

agttgtcaca gaaaacagta gagtgtacca cgtggcttct gtgtacttgc atggacacag   5220

gagaggctct gaagttttcc ctgagtgaga gtggaagaag actaggactg gttccatgtg   5280

gggcagtagg agttcagctg tcagaaatcc aggaccagaa gtggacagtg aaaccacaca   5340

ttggagaggt gttttgctat ttacctttac gaataaaaac aggcttgcca gttcatatca   5400

atgggtgctt tgctgttaca tcaaatagga aagaaatctg gaaaacagat acaaaaggac   5460

gatggaatac cacgttcatg agacatgtta ttgtgaaagc ttacttacag gtactgagtg   5520

tcttacggga cctggccact agtggggagc taatggatta tacttactat gcagtatggc   5580

ccgatcctga tttagttcat gatgattttt ctgtaatttg ccaaggattt tatgaagata   5640

tagctcatgg aaaagggaaa gaactgacca aagtcttctc tgatggatct acttgggttt   5700

ccatgaagaa cgtaagattt ctagatgact ctatacttaa aagaagagat gttggttcag   5760

cagccttcaa gatatttttg aaatacctca agaagactgg gtccaaaaac ctttgtgctg   5820

ttgaacttcc ttcttcggta aaattaggat ttgaagaagc tggctgcaaa cagatactac   5880

ttgaaaacac attttcagag aaacagtttt tttctgaagt gttttttcca aatattcaag   5940

aaattgaagc agaacttaga gatcctttaa tgatctttgt tctaaatgaa aaagttgatg   6000

agttctcggg agttcttcgt gttactccat gtattccttg ttccttggag gggcatcctt   6060

tggttttgcc atcaagattg atccaccccg aaggacgagt tgcaaagtta tttgatatta   6120

aagatgggag attcccttat ggttctactc aggattatct caatcctatt attttgatta   6180

aactagttca gttaggtatg gcaaaagatg atattttatg ggatgatatg ctagaacgtg   6240

cagtgtcagt agctgaaatt aataaaagtg atcatgttgc tgcatgccta agaagtagta   6300

tcttattgag tcttatcgat gagaaactaa aaataaggga tcctagagca aaggattttg   6360

ctgcaaaata tcaaacaatc cgcttccttc catttctgac aaaaccagca ggtttttctt   6420

tggactggaa aggcaacagt tttaagcctg aaaccatgtt tgcagcaact gacctttata   6480

cagctgaaca tcaagatata gtttgtcttt tgcaaccaat tctaaatgaa aattcccatt   6540

cttttagagg ttgtggttca gtgtcattgg ctgttaaaga gtttttggga ttactcaaga   6600

agccaacagt tgatctggtt ataaaccaat tgaaagaagt agcaaaatca gttgatgatg   6660

gaattacact gtaccaggag aatatcacca atgcttgcta caaatacctt catgaagcct   6720

tgatgcaaaa tgaaatcact aagatgtcaa ttattgataa gttaaaaccc tttagcttca   6780

ttctagttga gaatgcatat gttgactcag aaaaggtttc ttttcattta aattttgagg   6840

cggcaccata cctttatcag ttgcctaata agtataaaaa taatttccgc gaactttttg   6900

aaaccgtggg tgtgaggcag tcatgcactg ttgaagattt tgctcttgtt ttggaatcta   6960

ttgatcaaga aagaggaaca aagcaaataa cagaagagaa ttttcagctt tgccgacgaa   7020

taatcagtga aggaatatgg agtctcatta gagaaaagaa acaagaattt tgtgagaaaa   7080

attatggcaa gatattattg ccagatacta atcttatgct tctccctgct aaatcgttat   7140

gctacaatga ttgcccttgg ataaaagtaa aggataccac tgtaaaatat tgtcatgctg   7200

acatacccag ggaagtagca gtaaaactag gagcagtccc aaagcgacac aaagccttag   7260

aaagatatgc atccaatgtc tgttttacaa cacttggcac agaatttggg cagaaagaaa   7320

aattgaccag cagaattaag agcatcctta atgcatatcc ttctgaaaag gaaatgttga   7380

aagagcttct tcaaaatgct gatgatgcaa aggcgacaga aatctgtttt gtgtttgatc   7440

ctagacagca tccagttgat agaatatttg atgataagtg ggccccattg caagggccag   7500

cactttgtgt gtacaacaac cagccattta cagaagatga tgttagagga attcagaatc   7560

ttggaaaagg cacgaaagag ggaaatcctt ataaaactgg acagtatgga ataggattca   7620

attctgtgta tcatatcaca gactgcccat cttttatttc tggcaatgac atcctgtgta   7680

tttttgatcc tcatgccaga tatgcaccag gggccacatc cattagtccc ggacgcatgt   7740

ttagagattt ggatgcagat tttaggacac agttctcaga tgttctggat ctttatctgg   7800

gaacccattt taaactggat aattgcacaa tgttcagatt tcctcttcgt aatgcagaaa   7860

tggcaaaagt ttcggaaatt tcgtctgttc cagcatcaga cagaatggtc cagaatcttt   7920

tggacaaact gcgctcagat ggggcagaac ttctaatgtt tcttaatcac atggaaaaaa   7980

tttctatttg tgaaatagat aagagtactg gagctctaaa tgtgctgtat tcagtaaagg   8040

gcaaaatcac agatggagac agattgaaaa ggaaacaatt tcatgcatct gtaattgata   8100

gtgttactaa aaagaggcag ctcaaagaca taccagttca acaaataacc tatactatgg   8160

atactgagga ctctgaagga aatcttacta cgtggctaat ttgtaataga tcaggctttt   8220

caagtatgga gaaagtatct aaaagtgtca tatcagctca caagaaccaa gatattactc   8280

ttttcccacg tggtggagta gctgcctgca ttactcacaa ctataaaaaa ccccataggg   8340

ccttctgttt tttgcctctt tctttggaga ctgggctgcc atttcatgtg aatggccact   8400

ttgcactgga ttcagccaga aggaacctgt ggcgtgatga taatggagtt ggtgttcgaa   8460

gtgactggaa taacagttta atgacagcat taatagctcc tgcatatgtt gaattgctaa   8520

tacagttaaa aaaacggtat ttccctggtt ctgatccaac attatcagtg ttacagaaca   8580

cccctattca tgttgtaaag gacactttaa agaagttttt atcgtttttc ccagttaacc   8640

gtcttgatct acagccagat ttatattgtc tagtgaaagc actttacaat tgcattcacg   8700

aagacatgaa acgtctttta cctgttgtgc gggctccaaa tattgatggc tctgacttgc   8760

actctgcagt tataattact tggatcaata tgtctacttc taataaaact agaccatttt   8820

ttgacaattt actacaggat gaattacaac accttaaaaa tgcagattat aatatcacca   8880

cacgcaaaac agtagcagag aatgtctata ggctgaaaca tctcctttta gaaattggtt   8940

tcaacttggt ttataactgt gatgaaactg ctaatcttta ccactgtctt atagatgcag   9000

atattcctgt tagttatgtg acccctgctg atatcagatc ttttttaatg acattttcct   9060

ctcctgacac taattgccat attgggaagc tgccttgtcg tctgcagcag actaatctaa   9120

aactttttca tagtttaaaa cttttagttg attattgttt taaagatgca gaagaaaatg   9180

agattgaagt tgagggattg ccccttctca tcacactgga cagtgttttg caaacttttg   9240

atgcaaaacg acccaagttt ctaacaacat atcatgaatt gattccatcc cgcaaagact   9300

tgtttatgaa tacattatat ttgaaatata gtaatatttt attgaactgt aaagttgcaa   9360

aagtgtttga catttccagc tttgctgatt tgttatcctc tgtgttgcct cgagaatata   9420

agaccaaaag ttgcacaaag tggaaagaca attttgcaag tgagtcttgg cttaagaatg   9480

catggcattt tattagtgaa tctgtaagtg tgaaagaaga tcaggaagaa acaaaaccaa   9540

catttgacat tgttgttgat actctaaaag actgggcatt gcttccagga acaaagttta   9600

ctgtttcagc caaccagctt gtggttcctg aaggagatgt tctgcttcct ctcagcctta   9660

tgcacattgc agtttttcca aatgcccaga gtgataaagt ttttcatgct ctaatgaaag   9720

ccggctgtat tcagcttgct ttgaacaaaa tctgttccaa agacagtgca tttgttcctt   9780

tgttgtcatg tcacacagca aatatagaga gccccacaag catcttgaag gctctacatt   9840

atatggtcca aacttcaaca tttagagcag aaaaattagt agaaaatgat tttgaggcac   9900

ttttgatgta tttcaactgc aatttgaatc atttgatgtc ccaagatgat ataaaaattc   9960

taaagtcact tccgtgctat aaatccatca gtggccgcta tgtaagcatt ggaaaatttg  10020

gaacatgcta cgtacttaca aaaagtatcc cttcagctga agtggagaaa tggacacaat  10080

catcatcatc tgcatttctt gaagaaaaaa tacacttaaa agaactatat gaggtgattg  10140

gttgtgtacc tgtagatgat cttgaggtat atttgaaaca cctcttacca aaaattgaaa  10200

atctctctta tgatgcaaaa ttagagcact tgatctacct taagaataga ttatcaagtg  10260

ctgaggaatt atcagagatt aaggaacaac tttttgaaaa actggaaagt ttattgataa  10320

tccatgatgc taacagtaga ctaaagcaag caaagcattt ctatgataga actgtgagag  10380

tttttgaagt tatgcttcct gaaaaattgt ttattcctaa tgatttcttt aagaaattgg  10440

aacaacttat aaaacccaaa aatcatgtta catttatgac atcctgggtg gaattcttaa  10500

gaaatattgg actaaaatac atactttctc agcagcagtt gttacagttt gctaaggaaa  10560

tcagtgtgag ggctaataca gaaaactggt ccaaagaaac attgcaaaat acagttgata  10620

tccttctgca tcatatattc caagaacgaa tggatttgtt atctggaaat tttctgaaag  10680

aactatcttt aataccattc ttatgtcctg agcgggcccc cgcggaattc attagatttc  10740

atcctcaata tcaagaggta aatggaacac ttcctcttat aaagttcaat ggagcacagg  10800

taaatccaaa attcaagcaa tgtgatgtac tccagctgtt atggacatcc tgccctattc  10860

ttccagagaa agctacaccc ttaagcatta aagaacaaga aggtagtgac cttggtccac  10920

aagaacagct tgaacaagtt ttaaatatgc ttaatgttaa cctggatcct cctcttgata  10980

aggtaatcaa taactgcaga aacatatgca acataacgac gttggatgaa gaaatggtaa  11040

aaactagagc aaaagtctta aggagcatat atgaattcct cagtgcagaa aaaagggaat  11100

ttcgttttca gttgcgaggg gttgcttttg tgatggtaga agatggttgg aaacttctga  11160

agcctgagga ggtagtcata aacctagaat atgaatctga ttttaaacct tatttgtaca  11220

agctaccttt agaacttggc acatttcacc agttgttcaa acacttaggt actgaagata  11280

ttatttcaac taagcaatat gttgaagtgt tgagccgcat atttaaaaat tctgagggca  11340

aacaattaga tcctaatgaa atgcgtacag ttaagagagt agtttctggt ctgttcagga  11400

gtctacagaa tgattcagtc aaggtgagga gtgatctcga gaatgtacga gaccttgcgc  11460

tttacctccc aagccaggat ggtagattgg taaagtcaag catcttagtg tttgacgatg  11520

cgccacatta taaaagtaga atccagggga atattggtgt gcaaatgtta gttgatctca  11580

gccagtgcta cttagggaaa gaccatggat ttcacactaa gttgataatg ctctttcctc  11640

aaaaacttag acctcgatta ttgagcagta tacttgaaga acaattagat gaagagactc  11700

ccaaagtttg tcagtttgga gcgttgtgtt ctcttcaagg aagattgcag ttactcttgt  11760

cttctgaaca gttcattaca ggactgatta gaattatgaa gcatgaaaat gataatgctt  11820

ttctggccaa tgaagaaaaa gccataagac tttgcaaagc cctaagagaa ggattgaaag  11880

tatcctgctt tgaaaagctt caaacaacat taagagttaa aggttttaat cctattcccc  11940

acagcagaag tgaaactttt gcttttttga agcgatttgg taatgcagtc atcttgctct  12000

acattcaaca ttcagacagt aaagacatta atttcctgtt agcactggca atgactctta  12060

aatcagcaac tgacaatttg atttctgaca cttcatattt aattgctatg ctaggatgca  12120

atgatattta caggattggt gagaaacttg acagtttagg agtgaaatat gactcttcgg  12180

agccatcaaa actggaactt ccaatgcctg gcacaccaat tcctgctgaa attcattaca  12240

ctctgcttat ggacccaatg aatgtttttt acccgggaga atatgttggg taccttgttg  12300

atgctgaagg tggtgatatc tatggatcat accagccaac atacacatat gcaattattg  12360

tacaagaagt tgaaagagaa gatgctgaca attctagttt tctaggaaag atatatcaga  12420

tagatattgg ttatagtgaa tataaaatag ttagctctct tgatctgtat aagttttcaa  12480

gacctgagga aagctctcaa agcagggaca gtgctccttc tacaccaacc agccccactg  12540

agttcctcac ccctggcctg agaagcattc ctcctctttt ctctggtaga gagagccaca  12600

agacttcttc caaacatcag tcccccaaaa agcttaaggt taattcttta ccagaaatct  12660

taaaagaagt gacatctgtg gtggagcaag catggaagct tccagaatcg gaacgaaaaa  12720

agattattag gcggttgtat ttgaaatggc atcctgacaa aaatccagag aaccatgaca  12780

ttgccaatga agtttttaaa catttgcaga atgaaatcaa cagattagaa aaacaggctt  12840

ttctagatca aaatgcagac agggcctcca gacgaacatt ttcaacctca gcatcccgat  12900

ttcagtcaga caaatactca tttcagagat tctatacttc atggaatcaa gaagcaacga  12960

gccataaatc tgaaagacag caacagaaca aagaaaaatg ccccccttca gccggacaga  13020

cttactctca aaggttcttt gttcctccca ctttcaagtc ggttggcaat ccagtggaag  13080

cacgcagatg gctaagacaa gccagagcaa acttctcagc tgccaggaat gaccttcata  13140

aaaatgccaa tgagtgggtg tgctttaaat gttacctttc taccaagtta gctttgattg  13200

cagctgacta tgctgtgagg ggaaagtctg ataaagatgt aaaaccaact gcacttgctc  13260

agaaaataga ggaatatagt cagcaacttg aaggactgac aaatgatgtt cacacattgg  13320

aagcttatgg tgtagacagt ttaaaaacaa gataccctga tttgcttccc tttcctcaga  13380

tcccaaatga caggttcact tctgaggttg ctatgagggt gatggaatgt actgcctgta  13440

tcataataaa acttgaaaat tttatgcaac aaaaagtgtg aagatattta acgaaaaaaa  13500

aggtagatct tgaatgtgtt gtagcacgaa taaattgctg tacttcatta agcttcattg  13560

ccaattagct aggaattgtt aagcacattg cagattgttc ttggagaatt ctggagttgt  13620

tatgaacatg aataccaacg gaaaacctta actgaatcta aaagaaaact attttgaaga  13680

tggtggtgag ctgcaaaata gctggatgga tttgaatgat tgggatgata catcattgaa  13740

ctgcacttta tataaccaaa gcttagcagt ttgttagata agagtctatg tatgtctctg  13800

gttaggatga agttaatttt atgtttttaa catggtattt ttgaaggagc taatgaaaca  13860

ctggacatat aattggttta aacataaggg gaattaagtc tttgtagtct gtcatttttt  13920

taagtggatc ctcttggatg cgttattttc tcatcagctg gctctgatca tgaatttgtt  13980

gtaattttat gttgtactca gtgcatttaa gaaatggtag agtattttaa tcctattact  14040

tgactaagag tgtgaaggta gtacttttta gagtgcactg agtgcacttt acatctttat  14100

ttaaattttt ttttaacatc ttatgtttac aggcttcctg tttgatgaag atagcaacgg  14160

aaaactcaaa atggtggcag ttcttattac cagttgttag tattgtttct ggaaactgct  14220

tgccaagaca acatttatta actgttagaa cacttgcttt atgtttgtgt gtacatattt  14280

tccacaaatg ttataattta tatagtgtgg ttgaacagga tgcaatcttt tgttgtctaa  14340

aggtgctgca gttaaaaaaa aaacaacctt ttctttcaat atggcatgta gtggagtttt  14400

tttaacttta aaaacatcaa aaattgttaa aatcattgtg ttatctagta gtttataatt  14460

atcggcttat atttccccat gaatgatcag aactgacatt taattcatgt ttgtctcgcc  14520

atgcttcttt actttaacat atttcttttg cagaatgtaa aaggtaatga taattagttt  14580

atataagtgt actggctgta aatgatgcta aatatacttt atgcaattaa gggcttacag  14640

aacatgttga aacttttttt acttttattg ggaataagga atgtttgcac ctccacattt  14700

tattgcttct ggatgtgaaa tcatgtaatt atttctgctg ttatataaag tgccatactt  14760

ttaataaagg aaaatgtaca tatgaaatca aaaaaaaaaa aaaaa                  14805


<210>  938
<211>  4432
<212>  PRT
<213>  Homo sapiens

<400>  938

Met Ala Pro Tyr Gln Gly Pro Ala Leu Tyr Val Tyr Asn Asn Ala Val 
1               5                   10                  15


Phe Thr Pro Glu Asp Trp His Gly Ile Gln Glu Ile Ala Arg Ser Arg 
            20                  25                  30


Lys Lys Asp Asp Pro Leu Lys Val Gly Arg Phe Gly Ile Gly Phe Asn 
        35                  40                  45


Ser Val Tyr His Ile Thr Asp Val Pro Cys Ile Phe Ser Gly Asp Gln 
    50                  55                  60


Ile Gly Met Leu Asp Pro His Gln Thr Leu Phe Gly Pro His Glu Ser 
65                  70                  75                  80


Gly Gln Cys Trp Asn Leu Lys Asp Asp Ser Lys Glu Ile Ser Glu Leu 
                85                  90                  95


Ser Asp Gln Phe Ala Pro Phe Val Gly Ile Phe Gly Ser Thr Lys Glu 
            100                 105                 110


Thr Phe Ile Asn Gly Asn Phe Pro Gly Thr Phe Phe Arg Phe Pro Leu 
        115                 120                 125


Arg Leu Gln Pro Ser Gln Leu Ser Ser Asn Leu Tyr Asn Lys Gln Lys 
    130                 135                 140


Val Leu Glu Leu Phe Glu Ser Phe Arg Ala Asp Ala Asp Thr Val Leu 
145                 150                 155                 160


Leu Phe Leu Lys Ser Val Gln Asp Val Ser Leu Tyr Val Arg Glu Ala 
                165                 170                 175


Asp Gly Thr Glu Lys Leu Val Phe Arg Val Thr Ser Ser Glu Ser Lys 
            180                 185                 190


Ala Leu Lys His Glu Arg Pro Asn Ser Ile Lys Ile Leu Gly Thr Ala 
        195                 200                 205


Ile Ser Asn Tyr Cys Lys Lys Thr Pro Ser Asn Asn Ile Thr Cys Val 
    210                 215                 220


Thr Tyr His Val Asn Ile Val Leu Glu Glu Glu Ser Thr Lys Asp Ala 
225                 230                 235                 240


Gln Lys Thr Ser Trp Leu Val Cys Asn Ser Val Gly Gly Arg Gly Ile 
                245                 250                 255


Ser Ser Lys Leu Asp Ser Leu Ala Asp Glu Leu Lys Phe Val Pro Ile 
            260                 265                 270


Ile Gly Ile Ala Met Pro Leu Ser Ser Arg Asp Asp Glu Ala Lys Gly 
        275                 280                 285


Ala Thr Ser Asp Phe Ser Gly Lys Ala Phe Cys Phe Leu Pro Leu Pro 
    290                 295                 300


Pro Gly Glu Glu Ser Ser Thr Gly Leu Pro Val His Ile Ser Gly Phe 
305                 310                 315                 320


Phe Gly Leu Thr Asp Asn Arg Arg Ser Ile Lys Trp Arg Glu Leu Asp 
                325                 330                 335


Gln Trp Arg Asp Pro Ala Ala Leu Trp Asn Glu Phe Leu Val Met Asn 
            340                 345                 350


Val Val Pro Lys Ala Tyr Ala Thr Leu Ile Leu Asp Ser Ile Lys Arg 
        355                 360                 365


Leu Glu Met Glu Lys Ser Ser Asp Phe Pro Leu Ser Val Asp Val Ile 
    370                 375                 380


Tyr Lys Leu Trp Pro Glu Ala Ser Lys Val Lys Val His Trp Gln Pro 
385                 390                 395                 400


Val Leu Glu Pro Leu Phe Ser Glu Leu Leu Gln Asn Ala Val Ile Tyr 
                405                 410                 415


Ser Ile Ser Cys Asp Trp Val Arg Leu Glu Gln Val Tyr Phe Ser Glu 
            420                 425                 430


Leu Asp Glu Asn Leu Glu Tyr Thr Lys Thr Val Leu Asn Tyr Leu Gln 
        435                 440                 445


Ser Ser Gly Lys Gln Ile Ala Lys Val Pro Gly Asn Val Asp Ala Ala 
    450                 455                 460


Val Gln Leu Thr Ala Ala Ser Gly Thr Thr Pro Val Arg Lys Val Thr 
465                 470                 475                 480


Pro Ala Trp Val Arg Gln Val Leu Arg Lys Cys Ala His Leu Gly Cys 
                485                 490                 495


Ala Glu Glu Lys Leu His Leu Leu Glu Phe Val Leu Ser Asp Gln Ala 
            500                 505                 510


Tyr Ser Glu Leu Leu Gly Leu Glu Leu Leu Pro Leu Gln Asn Gly Asn 
        515                 520                 525


Phe Val Pro Phe Ser Ser Ser Val Ser Asp Gln Asp Val Ile Tyr Ile 
    530                 535                 540


Thr Ser Ala Glu Tyr Pro Arg Ser Leu Phe Pro Ser Leu Glu Gly Arg 
545                 550                 555                 560


Phe Ile Leu Asp Asn Leu Lys Pro His Leu Val Ala Ala Leu Lys Glu 
                565                 570                 575


Ala Ala Gln Thr Arg Gly Arg Pro Cys Thr Gln Leu Gln Leu Leu Asn 
            580                 585                 590


Pro Glu Arg Phe Ala Arg Leu Ile Lys Glu Val Met Asn Thr Phe Trp 
        595                 600                 605


Pro Gly Arg Glu Leu Ile Val Gln Trp Tyr Pro Phe Asp Glu Asn Arg 
    610                 615                 620


Asn His Pro Ser Val Ser Trp Leu Lys Met Val Trp Lys Asn Leu Tyr 
625                 630                 635                 640


Ile His Phe Ser Glu Asp Leu Thr Leu Phe Asp Glu Met Pro Leu Ile 
                645                 650                 655


Pro Arg Thr Ile Leu Glu Glu Gly Gln Thr Cys Val Glu Leu Ile Arg 
            660                 665                 670


Leu Arg Ile Pro Ser Leu Val Ile Leu Asp Asp Glu Ser Glu Ala Gln 
        675                 680                 685


Leu Pro Glu Phe Leu Ala Asp Ile Val Gln Lys Leu Gly Gly Phe Val 
    690                 695                 700


Leu Lys Lys Leu Asp Ala Ser Ile Gln His Pro Leu Ile Lys Lys Tyr 
705                 710                 715                 720


Ile His Ser Pro Leu Pro Ser Ala Val Leu Gln Ile Met Glu Lys Met 
                725                 730                 735


Pro Leu Gln Lys Leu Cys Asn Gln Ile Thr Ser Leu Leu Pro Thr His 
            740                 745                 750


Lys Asp Ala Leu Arg Lys Phe Leu Ala Ser Leu Thr Asp Ser Ser Glu 
        755                 760                 765


Lys Glu Lys Arg Ile Ile Gln Glu Leu Ala Ile Phe Lys Arg Ile Asn 
    770                 775                 780


His Ser Ser Asp Gln Gly Ile Ser Ser Tyr Thr Lys Leu Lys Gly Cys 
785                 790                 795                 800


Lys Val Leu His His Thr Ala Lys Leu Pro Ala Asp Leu Arg Leu Ser 
                805                 810                 815


Ile Ser Val Ile Asp Ser Ser Asp Glu Ala Thr Ile Arg Leu Ala Asn 
            820                 825                 830


Met Leu Lys Ile Glu Gln Leu Lys Thr Thr Ser Cys Leu Lys Leu Val 
        835                 840                 845


Leu Lys Asp Ile Glu Asn Ala Phe Tyr Ser His Glu Glu Val Thr Gln 
    850                 855                 860


Leu Met Leu Trp Val Leu Glu Asn Leu Ser Ser Leu Lys Asn Glu Asn 
865                 870                 875                 880


Pro Asn Val Leu Glu Trp Leu Thr Pro Leu Lys Phe Ile Gln Ile Ser 
                885                 890                 895


Gln Glu Gln Met Val Ser Ala Gly Glu Leu Phe Asp Pro Asp Ile Glu 
            900                 905                 910


Val Leu Lys Asp Leu Phe Cys Asn Glu Glu Gly Thr Tyr Phe Pro Pro 
        915                 920                 925


Ser Val Phe Thr Ser Pro Asp Ile Leu His Ser Leu Arg Gln Ile Gly 
    930                 935                 940


Leu Lys Asn Glu Ala Ser Leu Lys Glu Lys Asp Val Val Gln Val Ala 
945                 950                 955                 960


Lys Lys Ile Glu Ala Leu Gln Val Gly Ala Cys Pro Asp Gln Asp Val 
                965                 970                 975


Leu Leu Lys Lys Ala Lys Thr Leu Leu Leu Val Leu Asn Lys Asn His 
            980                 985                 990


Thr Leu Leu Gln Ser Ser Glu Gly Lys Met Thr Leu Lys Lys Ile Lys 
        995                 1000                1005


Trp Val Pro Ala Cys Lys Glu Arg Pro Pro Asn Tyr Pro Gly Ser Leu 
    1010                1015                1020


Val Trp Lys Gly Asp Leu Cys Asn Leu Cys Ala Pro Pro Asp Met Cys 
1025                1030                1035                1040


Asp Val Gly His Ala Ile Leu Ile Gly Ser Ser Leu Pro Leu Val Glu 
                1045                1050                1055


Ser Ile His Val Asn Leu Glu Lys Ala Leu Gly Ile Phe Thr Lys Pro 
            1060                1065                1070


Ser Leu Ser Ala Val Leu Lys His Phe Lys Ile Val Val Asp Trp Tyr 
        1075                1080                1085


Ser Ser Lys Thr Phe Ser Asp Glu Asp Tyr Tyr Gln Phe Gln His Ile 
    1090                1095                1100


Leu Leu Glu Ile Tyr Gly Phe Met His Asp His Leu Asn Glu Gly Lys 
1105                1110                1115                1120


Asp Ser Phe Arg Ala Leu Lys Phe Pro Trp Val Trp Thr Gly Lys Lys 
                1125                1130                1135


Phe Cys Pro Leu Ala Gln Ala Val Ile Lys Pro Ile His Asp Leu Asp 
            1140                1145                1150


Leu Gln Pro Tyr Leu His Asn Val Pro Lys Thr Met Ala Lys Phe His 
        1155                1160                1165


Gln Leu Phe Lys Val Cys Gly Ser Ile Glu Glu Leu Thr Ser Asp His 
    1170                1175                1180


Ile Ser Met Val Ile Gln Lys Ile Tyr Leu Lys Ser Asp Gln Asp Leu 
1185                1190                1195                1200


Ser Glu Gln Glu Ser Lys Gln Asn Leu His Leu Met Leu Asn Ile Ile 
                1205                1210                1215


Arg Trp Leu Tyr Ser Asn Gln Ile Pro Ala Ser Pro Asn Thr Pro Val 
            1220                1225                1230


Pro Ile His His Ser Lys Asn Pro Ser Lys Leu Ile Met Lys Pro Ile 
        1235                1240                1245


His Glu Cys Cys Tyr Cys Asp Ile Lys Val Asp Asp Leu Asn Asp Leu 
    1250                1255                1260


Leu Glu Asp Ser Val Glu Pro Ile Ile Leu Val His Glu Asp Ile Pro 
1265                1270                1275                1280


Met Lys Thr Ala Glu Trp Leu Lys Val Pro Cys Leu Ser Thr Arg Leu 
                1285                1290                1295


Ile Asn Pro Glu Asn Met Gly Phe Glu Gln Ser Gly Gln Arg Glu Pro 
            1300                1305                1310


Leu Thr Val Arg Ile Lys Asn Ile Leu Glu Glu Tyr Pro Ser Val Ser 
        1315                1320                1325


Asp Ile Phe Lys Glu Leu Leu Gln Asn Ala Asp Asp Ala Asn Ala Thr 
    1330                1335                1340


Glu Cys Ser Phe Leu Ile Asp Met Arg Arg Asn Met Asp Ile Arg Glu 
1345                1350                1355                1360


Asn Leu Leu Asp Pro Gly Met Ala Ala Cys His Gly Pro Ala Leu Trp 
                1365                1370                1375


Ser Phe Asn Asn Ser Gln Phe Ser Asp Ser Asp Phe Val Asn Ile Thr 
            1380                1385                1390


Arg Leu Gly Glu Ser Leu Lys Arg Gly Glu Val Asp Lys Val Gly Lys 
        1395                1400                1405


Phe Gly Leu Gly Phe Asn Ser Val Tyr His Ile Thr Asp Ile Pro Ile 
    1410                1415                1420


Ile Met Ser Arg Glu Phe Met Ile Met Phe Asp Pro Asn Ile Asn His 
1425                1430                1435                1440


Ile Ser Lys His Ile Lys Asp Lys Ser Asn Pro Gly Ile Lys Ile Asn 
                1445                1450                1455


Trp Ser Lys Gln Gln Lys Arg Leu Arg Lys Phe Pro Asn Gln Phe Lys 
            1460                1465                1470


Pro Phe Ile Asp Val Phe Gly Cys Gln Leu Pro Leu Thr Val Glu Ala 
        1475                1480                1485


Pro Tyr Ser Tyr Asn Gly Thr Leu Phe Arg Leu Ser Phe Arg Thr Gln 
    1490                1495                1500


Gln Glu Ala Lys Val Ser Glu Val Ser Ser Thr Cys Tyr Asn Thr Ala 
1505                1510                1515                1520


Asp Ile Tyr Ser Leu Val Asp Glu Phe Ser Leu Cys Gly His Arg Leu 
                1525                1530                1535


Ile Ile Phe Thr Gln Ser Val Lys Ser Met Tyr Leu Lys Tyr Leu Lys 
            1540                1545                1550


Ile Glu Glu Thr Asn Pro Ser Leu Ala Gln Asp Thr Val Ile Ile Lys 
        1555                1560                1565


Lys Lys Ser Cys Ser Ser Lys Ala Leu Asn Thr Pro Val Leu Ser Val 
    1570                1575                1580


Leu Lys Glu Ala Ala Lys Leu Met Lys Thr Cys Ser Ser Ser Asn Lys 
1585                1590                1595                1600


Lys Leu Pro Ser Asp Glu Pro Lys Ser Ser Cys Ile Leu Gln Ile Thr 
                1605                1610                1615


Val Glu Glu Phe His His Val Phe Arg Arg Ile Ala Asp Leu Gln Ser 
            1620                1625                1630


Pro Leu Phe Arg Gly Pro Asp Asp Asp Pro Ala Ala Leu Phe Glu Met 
        1635                1640                1645


Ala Lys Ser Gly Gln Ser Lys Lys Pro Ser Asp Glu Leu Ser Gln Lys 
    1650                1655                1660


Thr Val Glu Cys Thr Thr Trp Leu Leu Cys Thr Cys Met Asp Thr Gly 
1665                1670                1675                1680


Glu Ala Leu Lys Phe Ser Leu Ser Glu Ser Gly Arg Arg Leu Gly Leu 
                1685                1690                1695


Val Pro Cys Gly Ala Val Gly Val Gln Leu Ser Glu Ile Gln Asp Gln 
            1700                1705                1710


Lys Trp Thr Val Lys Pro His Ile Gly Glu Val Phe Cys Tyr Leu Pro 
        1715                1720                1725


Leu Arg Ile Lys Thr Gly Leu Pro Val His Ile Asn Gly Cys Phe Ala 
    1730                1735                1740


Val Thr Ser Asn Arg Lys Glu Ile Trp Lys Thr Asp Thr Lys Gly Arg 
1745                1750                1755                1760


Trp Asn Thr Thr Phe Met Arg His Val Ile Val Lys Ala Tyr Leu Gln 
                1765                1770                1775


Val Leu Ser Val Leu Arg Asp Leu Ala Thr Ser Gly Glu Leu Met Asp 
            1780                1785                1790


Tyr Thr Tyr Tyr Ala Val Trp Pro Asp Pro Asp Leu Val His Asp Asp 
        1795                1800                1805


Phe Ser Val Ile Cys Gln Gly Phe Tyr Glu Asp Ile Ala His Gly Lys 
    1810                1815                1820


Gly Lys Glu Leu Thr Lys Val Phe Ser Asp Gly Ser Thr Trp Val Ser 
1825                1830                1835                1840


Met Lys Asn Val Arg Phe Leu Asp Asp Ser Ile Leu Lys Arg Arg Asp 
                1845                1850                1855


Val Gly Ser Ala Ala Phe Lys Ile Phe Leu Lys Tyr Leu Lys Lys Thr 
            1860                1865                1870


Gly Ser Lys Asn Leu Cys Ala Val Glu Leu Pro Ser Ser Val Lys Leu 
        1875                1880                1885


Gly Phe Glu Glu Ala Gly Cys Lys Gln Ile Leu Leu Glu Asn Thr Phe 
    1890                1895                1900


Ser Glu Lys Gln Phe Phe Ser Glu Val Phe Phe Pro Asn Ile Gln Glu 
1905                1910                1915                1920


Ile Glu Ala Glu Leu Arg Asp Pro Leu Met Ile Phe Val Leu Asn Glu 
                1925                1930                1935


Lys Val Asp Glu Phe Ser Gly Val Leu Arg Val Thr Pro Cys Ile Pro 
            1940                1945                1950


Cys Ser Leu Glu Gly His Pro Leu Val Leu Pro Ser Arg Leu Ile His 
        1955                1960                1965


Pro Glu Gly Arg Val Ala Lys Leu Phe Asp Ile Lys Asp Gly Arg Phe 
    1970                1975                1980


Pro Tyr Gly Ser Thr Gln Asp Tyr Leu Asn Pro Ile Ile Leu Ile Lys 
1985                1990                1995                2000


Leu Val Gln Leu Gly Met Ala Lys Asp Asp Ile Leu Trp Asp Asp Met 
                2005                2010                2015


Leu Glu Arg Ala Val Ser Val Ala Glu Ile Asn Lys Ser Asp His Val 
            2020                2025                2030


Ala Ala Cys Leu Arg Ser Ser Ile Leu Leu Ser Leu Ile Asp Glu Lys 
        2035                2040                2045


Leu Lys Ile Arg Asp Pro Arg Ala Lys Asp Phe Ala Ala Lys Tyr Gln 
    2050                2055                2060


Thr Ile Arg Phe Leu Pro Phe Leu Thr Lys Pro Ala Gly Phe Ser Leu 
2065                2070                2075                2080


Asp Trp Lys Gly Asn Ser Phe Lys Pro Glu Thr Met Phe Ala Ala Thr 
                2085                2090                2095


Asp Leu Tyr Thr Ala Glu His Gln Asp Ile Val Cys Leu Leu Gln Pro 
            2100                2105                2110


Ile Leu Asn Glu Asn Ser His Ser Phe Arg Gly Cys Gly Ser Val Ser 
        2115                2120                2125


Leu Ala Val Lys Glu Phe Leu Gly Leu Leu Lys Lys Pro Thr Val Asp 
    2130                2135                2140


Leu Val Ile Asn Gln Leu Lys Glu Val Ala Lys Ser Val Asp Asp Gly 
2145                2150                2155                2160


Ile Thr Leu Tyr Gln Glu Asn Ile Thr Asn Ala Cys Tyr Lys Tyr Leu 
                2165                2170                2175


His Glu Ala Leu Met Gln Asn Glu Ile Thr Lys Met Ser Ile Ile Asp 
            2180                2185                2190


Lys Leu Lys Pro Phe Ser Phe Ile Leu Val Glu Asn Ala Tyr Val Asp 
        2195                2200                2205


Ser Glu Lys Val Ser Phe His Leu Asn Phe Glu Ala Ala Pro Tyr Leu 
    2210                2215                2220


Tyr Gln Leu Pro Asn Lys Tyr Lys Asn Asn Phe Arg Glu Leu Phe Glu 
2225                2230                2235                2240


Thr Val Gly Val Arg Gln Ser Cys Thr Val Glu Asp Phe Ala Leu Val 
                2245                2250                2255


Leu Glu Ser Ile Asp Gln Glu Arg Gly Thr Lys Gln Ile Thr Glu Glu 
            2260                2265                2270


Asn Phe Gln Leu Cys Arg Arg Ile Ile Ser Glu Gly Ile Trp Ser Leu 
        2275                2280                2285


Ile Arg Glu Lys Lys Gln Glu Phe Cys Glu Lys Asn Tyr Gly Lys Ile 
    2290                2295                2300


Leu Leu Pro Asp Thr Asn Leu Met Leu Leu Pro Ala Lys Ser Leu Cys 
2305                2310                2315                2320


Tyr Asn Asp Cys Pro Trp Ile Lys Val Lys Asp Thr Thr Val Lys Tyr 
                2325                2330                2335


Cys His Ala Asp Ile Pro Arg Glu Val Ala Val Lys Leu Gly Ala Val 
            2340                2345                2350


Pro Lys Arg His Lys Ala Leu Glu Arg Tyr Ala Ser Asn Val Cys Phe 
        2355                2360                2365


Thr Thr Leu Gly Thr Glu Phe Gly Gln Lys Glu Lys Leu Thr Ser Arg 
    2370                2375                2380


Ile Lys Ser Ile Leu Asn Ala Tyr Pro Ser Glu Lys Glu Met Leu Lys 
2385                2390                2395                2400


Glu Leu Leu Gln Asn Ala Asp Asp Ala Lys Ala Thr Glu Ile Cys Phe 
                2405                2410                2415


Val Phe Asp Pro Arg Gln His Pro Val Asp Arg Ile Phe Asp Asp Lys 
            2420                2425                2430


Trp Ala Pro Leu Gln Gly Pro Ala Leu Cys Val Tyr Asn Asn Gln Pro 
        2435                2440                2445


Phe Thr Glu Asp Asp Val Arg Gly Ile Gln Asn Leu Gly Lys Gly Thr 
    2450                2455                2460


Lys Glu Gly Asn Pro Tyr Lys Thr Gly Gln Tyr Gly Ile Gly Phe Asn 
2465                2470                2475                2480


Ser Val Tyr His Ile Thr Asp Cys Pro Ser Phe Ile Ser Gly Asn Asp 
                2485                2490                2495


Ile Leu Cys Ile Phe Asp Pro His Ala Arg Tyr Ala Pro Gly Ala Thr 
            2500                2505                2510


Ser Ile Ser Pro Gly Arg Met Phe Arg Asp Leu Asp Ala Asp Phe Arg 
        2515                2520                2525


Thr Gln Phe Ser Asp Val Leu Asp Leu Tyr Leu Gly Thr His Phe Lys 
    2530                2535                2540


Leu Asp Asn Cys Thr Met Phe Arg Phe Pro Leu Arg Asn Ala Glu Met 
2545                2550                2555                2560


Ala Lys Val Ser Glu Ile Ser Ser Val Pro Ala Ser Asp Arg Met Val 
                2565                2570                2575


Gln Asn Leu Leu Asp Lys Leu Arg Ser Asp Gly Ala Glu Leu Leu Met 
            2580                2585                2590


Phe Leu Asn His Met Glu Lys Ile Ser Ile Cys Glu Ile Asp Lys Ser 
        2595                2600                2605


Thr Gly Ala Leu Asn Val Leu Tyr Ser Val Lys Gly Lys Ile Thr Asp 
    2610                2615                2620


Gly Asp Arg Leu Lys Arg Lys Gln Phe His Ala Ser Val Ile Asp Ser 
2625                2630                2635                2640


Val Thr Lys Lys Arg Gln Leu Lys Asp Ile Pro Val Gln Gln Ile Thr 
                2645                2650                2655


Tyr Thr Met Asp Thr Glu Asp Ser Glu Gly Asn Leu Thr Thr Trp Leu 
            2660                2665                2670


Ile Cys Asn Arg Ser Gly Phe Ser Ser Met Glu Lys Val Ser Lys Ser 
        2675                2680                2685


Val Ile Ser Ala His Lys Asn Gln Asp Ile Thr Leu Phe Pro Arg Gly 
    2690                2695                2700


Gly Val Ala Ala Cys Ile Thr His Asn Tyr Lys Lys Pro His Arg Ala 
2705                2710                2715                2720


Phe Cys Phe Leu Pro Leu Ser Leu Glu Thr Gly Leu Pro Phe His Val 
                2725                2730                2735


Asn Gly His Phe Ala Leu Asp Ser Ala Arg Arg Asn Leu Trp Arg Asp 
            2740                2745                2750


Asp Asn Gly Val Gly Val Arg Ser Asp Trp Asn Asn Ser Leu Met Thr 
        2755                2760                2765


Ala Leu Ile Ala Pro Ala Tyr Val Glu Leu Leu Ile Gln Leu Lys Lys 
    2770                2775                2780


Arg Tyr Phe Pro Gly Ser Asp Pro Thr Leu Ser Val Leu Gln Asn Thr 
2785                2790                2795                2800


Pro Ile His Val Val Lys Asp Thr Leu Lys Lys Phe Leu Ser Phe Phe 
                2805                2810                2815


Pro Val Asn Arg Leu Asp Leu Gln Pro Asp Leu Tyr Cys Leu Val Lys 
            2820                2825                2830


Ala Leu Tyr Asn Cys Ile His Glu Asp Met Lys Arg Leu Leu Pro Val 
        2835                2840                2845


Val Arg Ala Pro Asn Ile Asp Gly Ser Asp Leu His Ser Ala Val Ile 
    2850                2855                2860


Ile Thr Trp Ile Asn Met Ser Thr Ser Asn Lys Thr Arg Pro Phe Phe 
2865                2870                2875                2880


Asp Asn Leu Leu Gln Asp Glu Leu Gln His Leu Lys Asn Ala Asp Tyr 
                2885                2890                2895


Asn Ile Thr Thr Arg Lys Thr Val Ala Glu Asn Val Tyr Arg Leu Lys 
            2900                2905                2910


His Leu Leu Leu Glu Ile Gly Phe Asn Leu Val Tyr Asn Cys Asp Glu 
        2915                2920                2925


Thr Ala Asn Leu Tyr His Cys Leu Ile Asp Ala Asp Ile Pro Val Ser 
    2930                2935                2940


Tyr Val Thr Pro Ala Asp Ile Arg Ser Phe Leu Met Thr Phe Ser Ser 
2945                2950                2955                2960


Pro Asp Thr Asn Cys His Ile Gly Lys Leu Pro Cys Arg Leu Gln Gln 
                2965                2970                2975


Thr Asn Leu Lys Leu Phe His Ser Leu Lys Leu Leu Val Asp Tyr Cys 
            2980                2985                2990


Phe Lys Asp Ala Glu Glu Asn Glu Ile Glu Val Glu Gly Leu Pro Leu 
        2995                3000                3005


Leu Ile Thr Leu Asp Ser Val Leu Gln Thr Phe Asp Ala Lys Arg Pro 
    3010                3015                3020


Lys Phe Leu Thr Thr Tyr His Glu Leu Ile Pro Ser Arg Lys Asp Leu 
3025                3030                3035                3040


Phe Met Asn Thr Leu Tyr Leu Lys Tyr Ser Asn Ile Leu Leu Asn Cys 
                3045                3050                3055


Lys Val Ala Lys Val Phe Asp Ile Ser Ser Phe Ala Asp Leu Leu Ser 
            3060                3065                3070


Ser Val Leu Pro Arg Glu Tyr Lys Thr Lys Ser Cys Thr Lys Trp Lys 
        3075                3080                3085


Asp Asn Phe Ala Ser Glu Ser Trp Leu Lys Asn Ala Trp His Phe Ile 
    3090                3095                3100


Ser Glu Ser Val Ser Val Lys Glu Asp Gln Glu Glu Thr Lys Pro Thr 
3105                3110                3115                3120


Phe Asp Ile Val Val Asp Thr Leu Lys Asp Trp Ala Leu Leu Pro Gly 
                3125                3130                3135


Thr Lys Phe Thr Val Ser Ala Asn Gln Leu Val Val Pro Glu Gly Asp 
            3140                3145                3150


Val Leu Leu Pro Leu Ser Leu Met His Ile Ala Val Phe Pro Asn Ala 
        3155                3160                3165


Gln Ser Asp Lys Val Phe His Ala Leu Met Lys Ala Gly Cys Ile Gln 
    3170                3175                3180


Leu Ala Leu Asn Lys Ile Cys Ser Lys Asp Ser Ala Phe Val Pro Leu 
3185                3190                3195                3200


Leu Ser Cys His Thr Ala Asn Ile Glu Ser Pro Thr Ser Ile Leu Lys 
                3205                3210                3215


Ala Leu His Tyr Met Val Gln Thr Ser Thr Phe Arg Ala Glu Lys Leu 
            3220                3225                3230


Val Glu Asn Asp Phe Glu Ala Leu Leu Met Tyr Phe Asn Cys Asn Leu 
        3235                3240                3245


Asn His Leu Met Ser Gln Asp Asp Ile Lys Ile Leu Lys Ser Leu Pro 
    3250                3255                3260


Cys Tyr Lys Ser Ile Ser Gly Arg Tyr Val Ser Ile Gly Lys Phe Gly 
3265                3270                3275                3280


Thr Cys Tyr Val Leu Thr Lys Ser Ile Pro Ser Ala Glu Val Glu Lys 
                3285                3290                3295


Trp Thr Gln Ser Ser Ser Ser Ala Phe Leu Glu Glu Lys Ile His Leu 
            3300                3305                3310


Lys Glu Leu Tyr Glu Val Ile Gly Cys Val Pro Val Asp Asp Leu Glu 
        3315                3320                3325


Val Tyr Leu Lys His Leu Leu Pro Lys Ile Glu Asn Leu Ser Tyr Asp 
    3330                3335                3340


Ala Lys Leu Glu His Leu Ile Tyr Leu Lys Asn Arg Leu Ser Ser Ala 
3345                3350                3355                3360


Glu Glu Leu Ser Glu Ile Lys Glu Gln Leu Phe Glu Lys Leu Glu Ser 
                3365                3370                3375


Leu Leu Ile Ile His Asp Ala Asn Ser Arg Leu Lys Gln Ala Lys His 
            3380                3385                3390


Phe Tyr Asp Arg Thr Val Arg Val Phe Glu Val Met Leu Pro Glu Lys 
        3395                3400                3405


Leu Phe Ile Pro Asn Asp Phe Phe Lys Lys Leu Glu Gln Leu Ile Lys 
    3410                3415                3420


Pro Lys Asn His Val Thr Phe Met Thr Ser Trp Val Glu Phe Leu Arg 
3425                3430                3435                3440


Asn Ile Gly Leu Lys Tyr Ile Leu Ser Gln Gln Gln Leu Leu Gln Phe 
                3445                3450                3455


Ala Lys Glu Ile Ser Val Arg Ala Asn Thr Glu Asn Trp Ser Lys Glu 
            3460                3465                3470


Thr Leu Gln Asn Thr Val Asp Ile Leu Leu His His Ile Phe Gln Glu 
        3475                3480                3485


Arg Met Asp Leu Leu Ser Gly Asn Phe Leu Lys Glu Leu Ser Leu Ile 
    3490                3495                3500


Pro Phe Leu Cys Pro Glu Arg Ala Pro Ala Glu Phe Ile Arg Phe His 
3505                3510                3515                3520


Pro Gln Tyr Gln Glu Val Asn Gly Thr Leu Pro Leu Ile Lys Phe Asn 
                3525                3530                3535


Gly Ala Gln Val Asn Pro Lys Phe Lys Gln Cys Asp Val Leu Gln Leu 
            3540                3545                3550


Leu Trp Thr Ser Cys Pro Ile Leu Pro Glu Lys Ala Thr Pro Leu Ser 
        3555                3560                3565


Ile Lys Glu Gln Glu Gly Ser Asp Leu Gly Pro Gln Glu Gln Leu Glu 
    3570                3575                3580


Gln Val Leu Asn Met Leu Asn Val Asn Leu Asp Pro Pro Leu Asp Lys 
3585                3590                3595                3600


Val Ile Asn Asn Cys Arg Asn Ile Cys Asn Ile Thr Thr Leu Asp Glu 
                3605                3610                3615


Glu Met Val Lys Thr Arg Ala Lys Val Leu Arg Ser Ile Tyr Glu Phe 
            3620                3625                3630


Leu Ser Ala Glu Lys Arg Glu Phe Arg Phe Gln Leu Arg Gly Val Ala 
        3635                3640                3645


Phe Val Met Val Glu Asp Gly Trp Lys Leu Leu Lys Pro Glu Glu Val 
    3650                3655                3660


Val Ile Asn Leu Glu Tyr Glu Ser Asp Phe Lys Pro Tyr Leu Tyr Lys 
3665                3670                3675                3680


Leu Pro Leu Glu Leu Gly Thr Phe His Gln Leu Phe Lys His Leu Gly 
                3685                3690                3695


Thr Glu Asp Ile Ile Ser Thr Lys Gln Tyr Val Glu Val Leu Ser Arg 
            3700                3705                3710


Ile Phe Lys Asn Ser Glu Gly Lys Gln Leu Asp Pro Asn Glu Met Arg 
        3715                3720                3725


Thr Val Lys Arg Val Val Ser Gly Leu Phe Arg Ser Leu Gln Asn Asp 
    3730                3735                3740


Ser Val Lys Val Arg Ser Asp Leu Glu Asn Val Arg Asp Leu Ala Leu 
3745                3750                3755                3760


Tyr Leu Pro Ser Gln Asp Gly Arg Leu Val Lys Ser Ser Ile Leu Val 
                3765                3770                3775


Phe Asp Asp Ala Pro His Tyr Lys Ser Arg Ile Gln Gly Asn Ile Gly 
            3780                3785                3790


Val Gln Met Leu Val Asp Leu Ser Gln Cys Tyr Leu Gly Lys Asp His 
        3795                3800                3805


Gly Phe His Thr Lys Leu Ile Met Leu Phe Pro Gln Lys Leu Arg Pro 
    3810                3815                3820


Arg Leu Leu Ser Ser Ile Leu Glu Glu Gln Leu Asp Glu Glu Thr Pro 
3825                3830                3835                3840


Lys Val Cys Gln Phe Gly Ala Leu Cys Ser Leu Gln Gly Arg Leu Gln 
                3845                3850                3855


Leu Leu Leu Ser Ser Glu Gln Phe Ile Thr Gly Leu Ile Arg Ile Met 
            3860                3865                3870


Lys His Glu Asn Asp Asn Ala Phe Leu Ala Asn Glu Glu Lys Ala Ile 
        3875                3880                3885


Arg Leu Cys Lys Ala Leu Arg Glu Gly Leu Lys Val Ser Cys Phe Glu 
    3890                3895                3900


Lys Leu Gln Thr Thr Leu Arg Val Lys Gly Phe Asn Pro Ile Pro His 
3905                3910                3915                3920


Ser Arg Ser Glu Thr Phe Ala Phe Leu Lys Arg Phe Gly Asn Ala Val 
                3925                3930                3935


Ile Leu Leu Tyr Ile Gln His Ser Asp Ser Lys Asp Ile Asn Phe Leu 
            3940                3945                3950


Leu Ala Leu Ala Met Thr Leu Lys Ser Ala Thr Asp Asn Leu Ile Ser 
        3955                3960                3965


Asp Thr Ser Tyr Leu Ile Ala Met Leu Gly Cys Asn Asp Ile Tyr Arg 
    3970                3975                3980


Ile Gly Glu Lys Leu Asp Ser Leu Gly Val Lys Tyr Asp Ser Ser Glu 
3985                3990                3995                4000


Pro Ser Lys Leu Glu Leu Pro Met Pro Gly Thr Pro Ile Pro Ala Glu 
                4005                4010                4015


Ile His Tyr Thr Leu Leu Met Asp Pro Met Asn Val Phe Tyr Pro Gly 
            4020                4025                4030


Glu Tyr Val Gly Tyr Leu Val Asp Ala Glu Gly Gly Asp Ile Tyr Gly 
        4035                4040                4045


Ser Tyr Gln Pro Thr Tyr Thr Tyr Ala Ile Ile Val Gln Glu Val Glu 
    4050                4055                4060


Arg Glu Asp Ala Asp Asn Ser Ser Phe Leu Gly Lys Ile Tyr Gln Ile 
4065                4070                4075                4080


Asp Ile Gly Tyr Ser Glu Tyr Lys Ile Val Ser Ser Leu Asp Leu Tyr 
                4085                4090                4095


Lys Phe Ser Arg Pro Glu Glu Ser Ser Gln Ser Arg Asp Ser Ala Pro 
            4100                4105                4110


Ser Thr Pro Thr Ser Pro Thr Glu Phe Leu Thr Pro Gly Leu Arg Ser 
        4115                4120                4125


Ile Pro Pro Leu Phe Ser Gly Arg Glu Ser His Lys Thr Ser Ser Lys 
    4130                4135                4140


His Gln Ser Pro Lys Lys Leu Lys Val Asn Ser Leu Pro Glu Ile Leu 
4145                4150                4155                4160


Lys Glu Val Thr Ser Val Val Glu Gln Ala Trp Lys Leu Pro Glu Ser 
                4165                4170                4175


Glu Arg Lys Lys Ile Ile Arg Arg Leu Tyr Leu Lys Trp His Pro Asp 
            4180                4185                4190


Lys Asn Pro Glu Asn His Asp Ile Ala Asn Glu Val Phe Lys His Leu 
        4195                4200                4205


Gln Asn Glu Ile Asn Arg Leu Glu Lys Gln Ala Phe Leu Asp Gln Asn 
    4210                4215                4220


Ala Asp Arg Ala Ser Arg Arg Thr Phe Ser Thr Ser Ala Ser Arg Phe 
4225                4230                4235                4240


Gln Ser Asp Lys Tyr Ser Phe Gln Arg Phe Tyr Thr Ser Trp Asn Gln 
                4245                4250                4255


Glu Ala Thr Ser His Lys Ser Glu Arg Gln Gln Gln Asn Lys Glu Lys 
            4260                4265                4270


Cys Pro Pro Ser Ala Gly Gln Thr Tyr Ser Gln Arg Phe Phe Val Pro 
        4275                4280                4285


Pro Thr Phe Lys Ser Val Gly Asn Pro Val Glu Ala Arg Arg Trp Leu 
    4290                4295                4300


Arg Gln Ala Arg Ala Asn Phe Ser Ala Ala Arg Asn Asp Leu His Lys 
4305                4310                4315                4320


Asn Ala Asn Glu Trp Val Cys Phe Lys Cys Tyr Leu Ser Thr Lys Leu 
                4325                4330                4335


Ala Leu Ile Ala Ala Asp Tyr Ala Val Arg Gly Lys Ser Asp Lys Asp 
            4340                4345                4350


Val Lys Pro Thr Ala Leu Ala Gln Lys Ile Glu Glu Tyr Ser Gln Gln 
        4355                4360                4365


Leu Glu Gly Leu Thr Asn Asp Val His Thr Leu Glu Ala Tyr Gly Val 
    4370                4375                4380


Asp Ser Leu Lys Thr Arg Tyr Pro Asp Leu Leu Pro Phe Pro Gln Ile 
4385                4390                4395                4400


Pro Asn Asp Arg Phe Thr Ser Glu Val Ala Met Arg Val Met Glu Cys 
                4405                4410                4415


Thr Ala Cys Ile Ile Ile Lys Leu Glu Asn Phe Met Gln Gln Lys Val 
            4420                4425                4430


<210>  939
<211>  1408
<212>  DNA
<213>  Homo sapiens

<400>  939
cgggaacgcc gctcttcgcc tctcagcggc ggcttgtcct ttgttccgga cgcccgctcc     60

tcagccctgc gtcctggggt cgctgctgca tcccgcacgc ctccaccggc tgcagaccca    120

tggccgagcg cggggaactc gacttgaccg gcgccaaaca gaacacagga gtgtggctag    180

tcaaggttcc taaatatttg tcacagcaat gggctaaagc ctctggaaga ggtgaagttg    240

ggaaactgcg gattgccaag actcaaggaa ggactgaggt gtcatttact ttgaatgagg    300

atcttgcaaa tattcatgat attggtggaa aaccagcttc agtcagtgct cctagagaac    360

atccatttgt cttgcaaagt gttggaggac agacattaac agtatttact gagagctcat    420

cagataagct gtcattggaa ggaatagtgg tacaaagagc tgaatgccga ccagctgcca    480

gtgaaaacta catgcgatta aaaagattgc aaatagaaga gtcttccaaa ccagtgaggc    540

tatcacaaca gctggacaaa gttgtaacaa ccaattacaa acctgttgct aatcatcaat    600

acaatatcga atatgaaagg aaaaagaaag aagacggaaa gcgagctcga gctgataaac    660

aacatgtttt agacatgcta ttttcagcct ttgagaaaca tcaatactat aatcttaagg    720

acttggtgga catcacaaaa caacctgtgg tgtacctgaa ggaaatctta aaagaaattg    780

gtgttcagaa tgtaaaaggg atccacaaaa acacatggga gctgaagcca gagtacagac    840

actatcaagg agaagaaaag agtgactaag aagactccta gccagcatgc tagtgaaagg    900

ctagcagcga tgctatgcaa aaggcgctga tactggaagg cttgaacacc gtatgtttaa    960

taggggttaa gtgacagtac tttgatttct ctcggtaaat tttttaaacc tgtaaggctt   1020

gtaaagtttc ttaactgttt ttttgaggag aaagaacaga tttatttata gacttaactt   1080

gtattaaacc agattattca cagtaggaat aggggttgga ggattaagag ggtttttctt   1140

aaatattagc ttttaatgtg tacaattagg aaattttttt aagtgaggac tctctaccct   1200

tgccgtatct aaggagctga ggtaatacag atccaaggag aattgtatag caagaaaaaa   1260

acagtcaact acagaaactc ttaaaaggaa taaaaaccca aagttcctta ttttgaaatt   1320

gtcaaagaac aaacggtgtt tttcttttaa acaggtgatc acgtttcttt tcatactcaa   1380

cgttaataaa aggagagagt ttgtagtg                                      1408


<210>  940
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  940

Met Ala Glu Arg Gly Glu Leu Asp Leu Thr Gly Ala Lys Gln Asn Thr 
1               5                   10                  15


Gly Val Trp Leu Val Lys Val Pro Lys Tyr Leu Ser Gln Gln Trp Ala 
            20                  25                  30


Lys Ala Ser Gly Arg Gly Glu Val Gly Lys Leu Arg Ile Ala Lys Thr 
        35                  40                  45


Gln Gly Arg Thr Glu Val Ser Phe Thr Leu Asn Glu Asp Leu Ala Asn 
    50                  55                  60


Ile His Asp Ile Gly Gly Lys Pro Ala Ser Val Ser Ala Pro Arg Glu 
65                  70                  75                  80


His Pro Phe Val Leu Gln Ser Val Gly Gly Gln Thr Leu Thr Val Phe 
                85                  90                  95


Thr Glu Ser Ser Ser Asp Lys Leu Ser Leu Glu Gly Ile Val Val Gln 
            100                 105                 110


Arg Ala Glu Cys Arg Pro Ala Ala Ser Glu Asn Tyr Met Arg Leu Lys 
        115                 120                 125


Arg Leu Gln Ile Glu Glu Ser Ser Lys Pro Val Arg Leu Ser Gln Gln 
    130                 135                 140


Leu Asp Lys Val Val Thr Thr Asn Tyr Lys Pro Val Ala Asn His Gln 
145                 150                 155                 160


Tyr Asn Ile Glu Tyr Glu Arg Lys Lys Lys Glu Asp Gly Lys Arg Ala 
                165                 170                 175


Arg Ala Asp Lys Gln His Val Leu Asp Met Leu Phe Ser Ala Phe Glu 
            180                 185                 190


Lys His Gln Tyr Tyr Asn Leu Lys Asp Leu Val Asp Ile Thr Lys Gln 
        195                 200                 205


Pro Val Val Tyr Leu Lys Glu Ile Leu Lys Glu Ile Gly Val Gln Asn 
    210                 215                 220


Val Lys Gly Ile His Lys Asn Thr Trp Glu Leu Lys Pro Glu Tyr Arg 
225                 230                 235                 240


His Tyr Gln Gly Glu Glu Lys Ser Asp 
                245


<210>  941
<211>  2133
<212>  DNA
<213>  Homo sapiens

<400>  941
tttccacaag accttctgga tccagctgaa tgtggaggcc tttaagagaa cttccagctc     60

ctgtaaaaac ccagaccaga ggactactga ccaacatttc aggctgatcc tccagacctc    120

gaagttactc tccttactct cctgactctt aattacatca cacctgtgtc gacactctct    180

gggaaaagac tgaagaaata atcttttcaa gaagcagaaa gctcctgcat acataggctg    240

atacgccacc tactgcaaaa ccgagctgac agcgcaggcg atgctgccag cgtttccatt    300

ccatcaccag gctggggctg aataaaggcg tgcttgtgtg gtagtgtctc tttttaaaaa    360

atctcaaagc caagaagaac aagctgaaat agcatcttca aaaaatggag cgtaaaataa    420

acagaagaga aaaagaaaag gagtatgaag ggaaacacaa cagcctggaa gatactgatc    480

aaggaaagaa ctgcaaatcc acactgatga ccctcaacgt tggtggatat ttatacatta    540

ctcaaaaaca aacactgacc aagtacccag acactttcct tgaaggtata gtaaatggaa    600

aaatcctctg cccgtttgat gctgatggtc attatttcat agacagggat ggtctcctct    660

tcaggcatgt cctaaacttc ctacgaaatg gagaacttct attgcccgaa gggtttcgag    720

aaaatcaact tcttgcacaa gaagcagaat tctttcagct caagggactg gcagaggaag    780

tgaaatccag gtgggagaaa gaacagctaa cacccagaga gactactttc ttggaaataa    840

cagataacca cgatcgttca caaggattaa gaatcttctg taatgctcct gatttcatat    900

caaaaataaa gtctcgcatt gttctggtgt ccaaaagcag gctggatgga tttccagagg    960

agttttcaat atcgtcaaat atcatccaat ttaaatactt cataaagtct gaaaatggca   1020

ctcgacttgt actaaaggaa gacaacacct ttgtctgtac cttggaaact cttaagtttg   1080

aggctatcat gatggcttta aagtgtggct ttagactgct gaccagcctg gattgttcca   1140

aagggtcaat tgttcacagc gatgcacttc attttatcaa gtaattacct gtgtcacgaa   1200

caaaggcaac aagcatgcag ccagcaagct tcggaaaacc acagcatcaa agacatccca   1260

aataacatgc ccagctagct ctgtactaca gagccctgct actaatcaat tactgtgagc   1320

taacggtatg taaattctat cgctaaagat gtccttcctc tggggtgttc ctactgatca   1380

gactcttcca cctaaaatga aaacagtaac cttctatata ctgtaaataa agactgaaag   1440

cttttgctat ttatttgtcc ttaagctgtc tttcaattca gattgtcttg ggtatttgca   1500

caaaaaagaa agcatgtaca ttatctatcg ttcatttaag taaatggtaa taaaatattt   1560

taaggggcta ttaatattta aaatcctttt ctactatggc aaaaatctac agagaaactg   1620

aactggcaaa attaactacc tggagcaaaa cagatgtgca gatctaacta aaacagagct   1680

atagtgaaac aaaatgagat tgtaagaaga cattaaagct attgatttga tttttccata   1740

gcaagcacca aaagcttata ttcacagttc ctgtgtttca tattagactt atagctgaat   1800

tggtattttg ctgaaaattc ctagaaaact gcttgatgac aataaaaagt aaataaaagc   1860

actgctacct tctttgattg tattaatgat tataataaaa agttacaggt cactttaaaa   1920

gcaaacagta ccacttgatg attttgcata aaattatgca ttgatgtcaa ccggcaggct   1980

acaggaaccc tggctggtcc tggaagtgac aaaaaccagc aaattcaatt ctttgcaggc   2040

tgagttccca caaagcatgg gtaacttagt ctcaatagag tatctgttat tagaataata   2100

aaggagttca ttttcagaaa aaaaaaaaaa aaa                                2133


<210>  942
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  942

Met Glu Arg Lys Ile Asn Arg Arg Glu Lys Glu Lys Glu Tyr Glu Gly 
1               5                   10                  15


Lys His Asn Ser Leu Glu Asp Thr Asp Gln Gly Lys Asn Cys Lys Ser 
            20                  25                  30


Thr Leu Met Thr Leu Asn Val Gly Gly Tyr Leu Tyr Ile Thr Gln Lys 
        35                  40                  45


Gln Thr Leu Thr Lys Tyr Pro Asp Thr Phe Leu Glu Gly Ile Val Asn 
    50                  55                  60


Gly Lys Ile Leu Cys Pro Phe Asp Ala Asp Gly His Tyr Phe Ile Asp 
65                  70                  75                  80


Arg Asp Gly Leu Leu Phe Arg His Val Leu Asn Phe Leu Arg Asn Gly 
                85                  90                  95


Glu Leu Leu Leu Pro Glu Gly Phe Arg Glu Asn Gln Leu Leu Ala Gln 
            100                 105                 110


Glu Ala Glu Phe Phe Gln Leu Lys Gly Leu Ala Glu Glu Val Lys Ser 
        115                 120                 125


Arg Trp Glu Lys Glu Gln Leu Thr Pro Arg Glu Thr Thr Phe Leu Glu 
    130                 135                 140


Ile Thr Asp Asn His Asp Arg Ser Gln Gly Leu Arg Ile Phe Cys Asn 
145                 150                 155                 160


Ala Pro Asp Phe Ile Ser Lys Ile Lys Ser Arg Ile Val Leu Val Ser 
                165                 170                 175


Lys Ser Arg Leu Asp Gly Phe Pro Glu Glu Phe Ser Ile Ser Ser Asn 
            180                 185                 190


Ile Ile Gln Phe Lys Tyr Phe Ile Lys Ser Glu Asn Gly Thr Arg Leu 
        195                 200                 205


Val Leu Lys Glu Asp Asn Thr Phe Val Cys Thr Leu Glu Thr Leu Lys 
    210                 215                 220


Phe Glu Ala Ile Met Met Ala Leu Lys Cys Gly Phe Arg Leu Leu Thr 
225                 230                 235                 240


Ser Leu Asp Cys Ser Lys Gly Ser Ile Val His Ser Asp Ala Leu His 
                245                 250                 255


Phe Ile Lys 



<210>  943
<211>  3364
<212>  DNA
<213>  Homo sapiens

<400>  943
gggggggggg cgctagggcc gagatcatgt ctgactggga gaggtttcct tggcagcaga     60

ggacgctagg tttgggatga aagaagctgg gcagatgcaa aatctggaga gcgcgagggc    120

cgggcggtca gtcagcaccc agactggcag catgaccggt cagataccaa ggctttctaa    180

agtcaacctt ttcactctgc tcagcctctg gatggagctc tttccagcag aagcccagcg    240

gcaaaaatct cagaaaaatg aagagggaaa gcatggaccc ttaggagata atgaagagag    300

gaccagagta tctactgaca aaagacaggt aaagagaact ggtcttgtgg tggtgaaaaa    360

catgaaaatt gttggtctcc actgttctag tgaagattta catgccgggc agattgctct    420

tattaaacat gggtcaaggc tgaaaaactg tgatctttat ttttccagaa aaccatgttc    480

tgcttgtttg aaaatgattg taaatgctgg agttaaccga atttcatact ggcctgctga    540

tccagaaata agtttgctta cggaggcttc tagttctgaa gatgcaaagt tagatgccaa    600

agcagtggaa agattgaagt caaacagtcg ggcccatgtg tgtgtcttac ttcaaccttt    660

ggtgtgttat atggtgcagt ttgtagagga gacctcttac aaatgtgact ttattcaaaa    720

aattacaaaa acattgccgg atgctaacac tgacttttat tatgaatgta aacaagaaag    780

aataaaagaa tatgaaatgt tatttttggt ttcaaatgaa gaaatgcata agcaaatact    840

gatgactata ggtttggaga acctgtgtga aaatccatac tttagcaatc taaggcaaaa    900

catgaaagac cttatcctac ttttggccac agtagcttcc agtgtgccga actttaaaca    960

cttcggattt taccgtagca atccagaaca gattaatgaa attcacaatc aaagtttgcc   1020

acaggaaatt gcaaggcact gcatggttca ggccaggtta ttggcatatc gaactgagga   1080

tcataaaaca ggagttgggg cagtcatttg ggcagaaggg aaatctagaa gttgtgatgg   1140

aacaggtgcc atgtactttg taggatgtgg ttacaatgct tttcctgttg gatctgagta   1200

tgctgacttc ccacacatgg atgacaagca gaaagacaga gaaataagga aattcagata   1260

catcatacat gcggaacaga atgccttgac atttaggtgt caagaaataa aaccagaaga   1320

aagaagcatg atttttgtga caaagtgccc atgtgatgag tgtgtacctt taattaaagg   1380

tgcaggcata aaacaaatct atgcaggaga tgtagatgtt ggaaaaaaga aggcagacat   1440

ctcttacatg aggttcgggg agcttgaagg tgttagcaaa tttacgtggc agctgaatcc   1500

atcaggagct tatggtcttg aacaaaatga gcctgaaagg agagaaaatg gtgtgttgag   1560

acctgtccca cagaaggaag agcagcacca ggacaagaag ctgcgcctcg gaatccacta   1620

agaaggcctg tctacactgc aggggaacct caagaacttt tcattgcact tctaaaattc   1680

agccttgttc attcagaaaa taaggatgga ttttgtgaat aattgaaaag attttttaag   1740

gaagctaatt tatttctagg atacaaatgg tgttaataag aatatttgtc ttttagattt   1800

atgtgtgggt tttccataat gtagtagtgt gttattttat tacacgaaat gagggagcaa   1860

taacttcaac caatgtaatc accaacaggg actgatttct atttatcttg actttatatt   1920

agccaatttg aaagggtctg cttcacaaga ggtcatgcct ctgcagggaa tcacacacct   1980

tttgagaaat attaattctt ttgaattaca agagtgacag ttagtaaact gctccaggga   2040

aataagtgtc atcttttaag agtcagtgta tagcaaacca aaagatcaca tttataccca   2100

aagctttcta gtaatcagaa tttacttaat tagaattgac tcataaaaat aaagttagtg   2160

gactttgtct ccatttttaa agtatatttt gtaaatgtta attctgtggt cctgtttatc   2220

acagactttg ggtagcaata ggaagagagt gttattctga gacagtgtcg ctgcttgata   2280

tcactgactc ttgaaatcac taacagtgaa cctcaaattt ggttatgatg ttaacagaga   2340

agaaatattt gagtctggaa tattgaaact agctttccta gaattccatt aataaatgct   2400

gctcccccat atagtcttcc cttctgtata attaacatag gttgtctcat ggctttgatc   2460

ttcaaaagga agagcctttt aaaaacattt gccaacctca agaataaata ctgaaagtct   2520

tgaaagtatg gtcatttcag ctattccaga ttgctgtctg tgatttctca catttttatt   2580

tgctgagaaa cattcagaaa attattccaa aaatgaaggt acattttctg ttctctccta   2640

ggttagagag gggtggcctg gggtgcttca tgagaaatgt cttcctggat ctgcggtggt   2700

caggtttgcc tctgcttttg ttccctgcct ttccgccaca tcacacggcc tcactgggct   2760

tcctaccagt ttctcagaat tacacgcacg accatccaaa cattggctcc atgccagggc   2820

tgtgactgca gcctgtgtag gaccatgggg agttcagagt catcatacaa ggcagccaag   2880

aactgccata aacactacac agatggaggg catgggatag gacaggagag gaggtgatgt   2940

acacttagag gtaactaagg ctagtttgaa aaccgtgaat taagatattc ttatcagtat   3000

aaaaacactg agattgctta cctcccaaat tgctttattg tattaactct catgcttcag   3060

ctcttggatt tgttgtttct aactaacatg tcatgtacac caaacatttt ataaatcaat   3120

cagtaaatat tttgtaagac ccaaaatcct ggcatattgc caggtctgtg gatttgcctg   3180

ttgggtgttg ggatgggata tcagaggaag aagcatacaa gtgggaaaaa ctgtgattag   3240

aaagggaaaa ataggcattt ccacagtact attaagagag gcatgataat gccatttttt   3300

ttcttctgta caactggtca gatttcaata aataatcatt gatggtaaaa aaaaaaaaaa   3360

aaaa                                                                3364


<210>  944
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  944

Met Lys Glu Ala Gly Gln Met Gln Asn Leu Glu Ser Ala Arg Ala Gly 
1               5                   10                  15


Arg Ser Val Ser Thr Gln Thr Gly Ser Met Thr Gly Gln Ile Pro Arg 
            20                  25                  30


Leu Ser Lys Val Asn Leu Phe Thr Leu Leu Ser Leu Trp Met Glu Leu 
        35                  40                  45


Phe Pro Ala Glu Ala Gln Arg Gln Lys Ser Gln Lys Asn Glu Glu Gly 
    50                  55                  60


Lys His Gly Pro Leu Gly Asp Asn Glu Glu Arg Thr Arg Val Ser Thr 
65                  70                  75                  80


Asp Lys Arg Gln Val Lys Arg Thr Gly Leu Val Val Val Lys Asn Met 
                85                  90                  95


Lys Ile Val Gly Leu His Cys Ser Ser Glu Asp Leu His Ala Gly Gln 
            100                 105                 110


Ile Ala Leu Ile Lys His Gly Ser Arg Leu Lys Asn Cys Asp Leu Tyr 
        115                 120                 125


Phe Ser Arg Lys Pro Cys Ser Ala Cys Leu Lys Met Ile Val Asn Ala 
    130                 135                 140


Gly Val Asn Arg Ile Ser Tyr Trp Pro Ala Asp Pro Glu Ile Ser Leu 
145                 150                 155                 160


Leu Thr Glu Ala Ser Ser Ser Glu Asp Ala Lys Leu Asp Ala Lys Ala 
                165                 170                 175


Val Glu Arg Leu Lys Ser Asn Ser Arg Ala His Val Cys Val Leu Leu 
            180                 185                 190


Gln Pro Leu Val Cys Tyr Met Val Gln Phe Val Glu Glu Thr Ser Tyr 
        195                 200                 205


Lys Cys Asp Phe Ile Gln Lys Ile Thr Lys Thr Leu Pro Asp Ala Asn 
    210                 215                 220


Thr Asp Phe Tyr Tyr Glu Cys Lys Gln Glu Arg Ile Lys Glu Tyr Glu 
225                 230                 235                 240


Met Leu Phe Leu Val Ser Asn Glu Glu Met His Lys Gln Ile Leu Met 
                245                 250                 255


Thr Ile Gly Leu Glu Asn Leu Cys Glu Asn Pro Tyr Phe Ser Asn Leu 
            260                 265                 270


Arg Gln Asn Met Lys Asp Leu Ile Leu Leu Leu Ala Thr Val Ala Ser 
        275                 280                 285


Ser Val Pro Asn Phe Lys His Phe Gly Phe Tyr Arg Ser Asn Pro Glu 
    290                 295                 300


Gln Ile Asn Glu Ile His Asn Gln Ser Leu Pro Gln Glu Ile Ala Arg 
305                 310                 315                 320


His Cys Met Val Gln Ala Arg Leu Leu Ala Tyr Arg Thr Glu Asp His 
                325                 330                 335


Lys Thr Gly Val Gly Ala Val Ile Trp Ala Glu Gly Lys Ser Arg Ser 
            340                 345                 350


Cys Asp Gly Thr Gly Ala Met Tyr Phe Val Gly Cys Gly Tyr Asn Ala 
        355                 360                 365


Phe Pro Val Gly Ser Glu Tyr Ala Asp Phe Pro His Met Asp Asp Lys 
    370                 375                 380


Gln Lys Asp Arg Glu Ile Arg Lys Phe Arg Tyr Ile Ile His Ala Glu 
385                 390                 395                 400


Gln Asn Ala Leu Thr Phe Arg Cys Gln Glu Ile Lys Pro Glu Glu Arg 
                405                 410                 415


Ser Met Ile Phe Val Thr Lys Cys Pro Cys Asp Glu Cys Val Pro Leu 
            420                 425                 430


Ile Lys Gly Ala Gly Ile Lys Gln Ile Tyr Ala Gly Asp Val Asp Val 
        435                 440                 445


Gly Lys Lys Lys Ala Asp Ile Ser Tyr Met Arg Phe Gly Glu Leu Glu 
    450                 455                 460


Gly Val Ser Lys Phe Thr Trp Gln Leu Asn Pro Ser Gly Ala Tyr Gly 
465                 470                 475                 480


Leu Glu Gln Asn Glu Pro Glu Arg Arg Glu Asn Gly Val Leu Arg Pro 
                485                 490                 495


Val Pro Gln Lys Glu Glu Gln His Gln Asp Lys Lys Leu Arg Leu Gly 
            500                 505                 510


Ile His 



<210>  945
<211>  3691
<212>  DNA
<213>  Homo sapiens

<400>  945
gtgacgttac aggactgagg agggaggaag taaaagggag ctgtgactgt ggtacgtatc     60

tgaaagcaag tgttagagag ggagtggaga acgcataagc aagctggttt gaccagaaac    120

agaactgcct gtgacagatt aagagacaag caaggcttgg aatctgagag caagcaaaga    180

gagtggaaat ttacagctgc cctatgtgag tgttcaagtg atcattttct ggtaacgttt    240

tccagtggta actgttactc ttcaaaaaga gggacagaaa gtcaagacct aattgtggaa    300

actcttttct ctgccacgct tggtaatagg aggcaacctc tattaaatgg acgataaagg    360

ctacttcatc taaagtgctt tgagctcaag aaagagctgt cttcagcacc tcaccatgtg    420

tctacatttt gttgcttaga aaagcctagg catttctgta acatttgcat tccatattgg    480

aagaagagat ttctacacat gaaaaaaatg cctttgttta gtaaatcaca caaaaatcca    540

gcagaaattg tgaaaatcct gaaagacaat ttggccattt tggaaaagca agacaaaaag    600

acagacaagg cttcagaaga agtgtctaaa tcactgcaag caatgaaaga aattctgtgt    660

ggtacaaacg agaaagaacc cccaacagaa gcagtggctc agctagcaca agaactctac    720

agcagtggcc tgctagtgac actgatagct gacctgcagc tgatagactt tgagggaaaa    780

aaagatgtga cccagatatt taacaacatc ttgagaagac agataggcac tcggagtcct    840

actgtggagt atattagtgc tcatcctcat atcctgttta tgctcctcaa aggatatgaa    900

gccccacaga ttgccttacg ttgtgggatt atgctgagag aatgtattcg acatgaacca    960

cttgccaaaa tcatcctctt ttctaatcaa ttcagagatt tctttaagta cgtggagttg   1020

tcaacatttg atattgcttc agatgccttt gctactttca aggatttact aaccagacat   1080

aaagtgttgg tagcagactt cttagaacaa aattacgaca ctatttttga agactatgag   1140

aaattgcttc agtctgagaa ttatgttact aagagacagt ctttaaagct gctaggggag   1200

ctgatcctgg accgtcacaa ctttgccatc atgacaaagt atatcagcaa gccggagaac   1260

ctgaaactca tgatgaacct ccttcgggat aaaagtccca acatccagtt tgaagccttt   1320

catgttttta aggtgtttgt ggccagtcct cacaaaacac agcctattgt ggagatcctg   1380

ttaaaaaatc agcccaaact cattgagttt ctgagcagct tccaaaaaga aaggacggat   1440

gatgagcagt tcgctgacga gaagaactac ttgattaaac agatccgaga cttgaagaaa   1500

acggcccctt gaagagctcc ccggcccctg tcacagtcag tcgtctcatt tgtccagttt   1560

gtacagtgtg tcatttcaga aagtcatcat tcttgggaag actttggagg tgcctatttt   1620

ttctgctgta attgttctgg gtagatggag tataaacatt tgaatggaaa aaaattaacc   1680

tagaataata tattcatttt agtcaagtct gtgattattt atgtgaaatg agaaccattg   1740

tatcagatgt tgataaaagc aattttaact tgcagatgtg agcccctggg cacaatgagc   1800

cgctaaatgg gagctcaatt gacaggcatc accaagtctt caaggaggac tgagttctca   1860

ggggagaact gggaatgggg ccagggtgca aaaatgcttt gcccatctgt aggtagacac   1920

acagatcgct cagggcactg agagatccca gaaggtaacg ttaatgtttt cagtcattgt   1980

gtgtcctttg ttgctgccaa tgtctttgga ctgtaatcag tgcatccaca cctcccagga   2040

tccagtgctc cctctcagct cagtctcccc tctctccctg tcctgcattc catcccagct   2100

cctcagcatg gcctcagtgg gcgcacccat gcctcccgca gtccaggtga gcaggggagc   2160

aactgagcag gaagaggatg gatcaacaag ggtcacgggg aataggggac ccacggggtg   2220

tgacctgctt gctagagaac tgtgaacatg tggctctgga tagagtgact gctgctccat   2280

attagcttcc agagggtgag tgagggacag aatatttcct tcataatggt catgggtgaa   2340

tgctttctgc tgtaagtgtc ttttagagta ggaatcagca tagtgggatg cccagcaggc   2400

acaaaccatg ggtccaggga gtctcagcgg ggaacttcta tcagtatcaa taaccattgg   2460

aaggagaaat gattcatgtg tgaaaaaatt ctcagatcca tcaataaatt tttttcagag   2520

ccattgtatc agatgttgat aaaagcaatt tttttctaat aagctgtcat tctataattg   2580

cccatcacag tctttagtga acacatagaa agcctataca gttttggtcc tgaatagtct   2640

cttgtgacta ggatgattga ggtgttaatt cctcttcctt ataaaaaggc ttggaatcaa   2700

aaatatttta aaaggccgtg gtttcgtttc agacatcaac catctaaaac gggattttaa   2760

agcgatattt tacaagaatg aaaggcacaa ttgttgatct gtatttttta cacttcagtt   2820

tctaaatcat gaatcgttgc cttccacagg aaccctccct tatacattac ttgagtgttg   2880

tgtagttttt cttcagccag gtatttctct gcctagagag gggaagagaa atgtgttctc   2940

caggactgat cccctttgta gattttgtac ctgaagagtt acctggcagg gcaccaccct   3000

tggctaggcc caggtgtgtg tttctttctt gcctggcatg gaccccgagg caggtgatgt   3060

ggggcctggc gcacctcccc gctttggcag ctgtggcctc cctggccagt gcccttgcag   3120

gaggccggcc ggcagcctga tgacccgtac tctttagtca ctgacgtcag attattttta   3180

taacgttccc tgacagttca gagtcccttc gaattgcact tttctggttt cgcttattta   3240

attaaaagag atgagtgtaa gtataaaaaa tgaaggtgaa ataaccattg gaattgtatt   3300

tggttactta atactgttcc acaacatctt gggacgtctg ttttcctttg gagagtgagg   3360

ccttgttatt attcttttct gataaagaaa acattttatt tcctttgggc ttgcattagc   3420

tctttcctag caacccatta tcccagctca gtacctttca aacagaaaac tagagtctgg   3480

ggttttgttg tgatctgaat ttgtaagtta ttaatgtgaa agggggagca ggaagctccc   3540

cctttgcaca aagggggatt tgtttgcaca aagttcactg taaatactgt gagaattgaa   3600

ttctgaaaag gtcatattta gtgatttcaa aagcacacat ttaaatgaag actgactaaa   3660

taaaaggtac cacacaaaaa aaaaaaaaaa a                                  3691


<210>  946
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  946

Met Lys Lys Met Pro Leu Phe Ser Lys Ser His Lys Asn Pro Ala Glu 
1               5                   10                  15


Ile Val Lys Ile Leu Lys Asp Asn Leu Ala Ile Leu Glu Lys Gln Asp 
            20                  25                  30


Lys Lys Thr Asp Lys Ala Ser Glu Glu Val Ser Lys Ser Leu Gln Ala 
        35                  40                  45


Met Lys Glu Ile Leu Cys Gly Thr Asn Glu Lys Glu Pro Pro Thr Glu 
    50                  55                  60


Ala Val Ala Gln Leu Ala Gln Glu Leu Tyr Ser Ser Gly Leu Leu Val 
65                  70                  75                  80


Thr Leu Ile Ala Asp Leu Gln Leu Ile Asp Phe Glu Gly Lys Lys Asp 
                85                  90                  95


Val Thr Gln Ile Phe Asn Asn Ile Leu Arg Arg Gln Ile Gly Thr Arg 
            100                 105                 110


Ser Pro Thr Val Glu Tyr Ile Ser Ala His Pro His Ile Leu Phe Met 
        115                 120                 125


Leu Leu Lys Gly Tyr Glu Ala Pro Gln Ile Ala Leu Arg Cys Gly Ile 
    130                 135                 140


Met Leu Arg Glu Cys Ile Arg His Glu Pro Leu Ala Lys Ile Ile Leu 
145                 150                 155                 160


Phe Ser Asn Gln Phe Arg Asp Phe Phe Lys Tyr Val Glu Leu Ser Thr 
                165                 170                 175


Phe Asp Ile Ala Ser Asp Ala Phe Ala Thr Phe Lys Asp Leu Leu Thr 
            180                 185                 190


Arg His Lys Val Leu Val Ala Asp Phe Leu Glu Gln Asn Tyr Asp Thr 
        195                 200                 205


Ile Phe Glu Asp Tyr Glu Lys Leu Leu Gln Ser Glu Asn Tyr Val Thr 
    210                 215                 220


Lys Arg Gln Ser Leu Lys Leu Leu Gly Glu Leu Ile Leu Asp Arg His 
225                 230                 235                 240


Asn Phe Ala Ile Met Thr Lys Tyr Ile Ser Lys Pro Glu Asn Leu Lys 
                245                 250                 255


Leu Met Met Asn Leu Leu Arg Asp Lys Ser Pro Asn Ile Gln Phe Glu 
            260                 265                 270


Ala Phe His Val Phe Lys Val Phe Val Ala Ser Pro His Lys Thr Gln 
        275                 280                 285


Pro Ile Val Glu Ile Leu Leu Lys Asn Gln Pro Lys Leu Ile Glu Phe 
    290                 295                 300


Leu Ser Ser Phe Gln Lys Glu Arg Thr Asp Asp Glu Gln Phe Ala Asp 
305                 310                 315                 320


Glu Lys Asn Tyr Leu Ile Lys Gln Ile Arg Asp Leu Lys Lys Thr Ala 
                325                 330                 335


Pro 



<210>  947
<211>  1952
<212>  DNA
<213>  Homo sapiens

<400>  947
gcctctggct gctctgttaa cgtgtcccgc gagcgaggcg cgtcgcaaaa ggtcgcggcg     60

gaacttccct gcgcttttca gaccatactc tttacggtac taggcactgc tgagctggga    120

gatgtcggcg gcgtgttggg aggaaccgtg gggtcttccc ggcggctttg cgaagcgggt    180

cctggtgacc ggcggtgctg gtttcattgc atcacatatg attgtctctt tagtggaaga    240

ttatccaaac tatatgatca taaatctaga caagctggat tactgtgcaa gcttgaagaa    300

tcttgaaacc atttctaaca aacagaacta caaatttata cagggtgaca tatgtgattc    360

tcactttgtg aaactgcttt ttgaaacaga gaaaatagat atagtactac attttgccgc    420

acaaacacat gtagatcttt cattcgtacg tgcctttgag tttacctatg ttaatgttta    480

tggcactcac gttttggtaa gtgctgctca tgaagccaga gtggagaagt ttatttatgt    540

cagcacagat gaagtatatg gtggcagtct tgataaggaa tttgatgaat cttcacccaa    600

acaacctaca aatccttatg catcatctaa agcagctgct gaatgttttg tacagtctta    660

ctgggaacaa tataagtttc cagttgtcat cacaagaagc agtaatgttt atggaccaca    720

tcaatatcca gaaaaggtta ttccaaaatt tatatctttg ctacagcaca acaggaaatg    780

ttgcattcat gggtcagggc ttcaaacaag aaacttcctt tatgctactg atgttgtaga    840

agcatttctc actgtcctca aaaaagggaa accaggtgaa atttataaca tcggaaccaa    900

ttttgaaatg tcagttgtcc agcttgccaa agaactaata caactgatca aagagaccaa    960

ttcagagtct gaaatggaaa attgggttga ttatgttaat gatagaccca ccaatgacat   1020

gagataccca atgaagtcag aaaaaataca tggcttagga tggagaccta aagtgccttg   1080

gaaagaagga ataaagaaaa caattgaatg gtacagagag aattttcaca actggaagaa   1140

tgtggaaaag gcattagaac cctttccggt ataatcacca tttatatagt cgagacagtt   1200

gtcaaagaag aaagttatcc tacctcgcca agtggtatga aattaagtga ccaaatgaag   1260

tgcactcttt tcttttggaa ttagattcat gactttctgt ataaaattca aatgcagaat   1320

gcctcaatct ttgggagagt ttcagtactg gcatagaatt taaatgtcaa aattctttct   1380

gaaacccttt ctcctagaaa ctaggaaata ataggtgtag aagactctcc ctaagggtag   1440

ccaggaagaa gtctcctgat tcggacaacc atgaggggta gtggtgctag ggagaaggca   1500

accttcactg gttttgaact cagtgcctaa gaaagtctct gaaatgttcg tttttaggca   1560

atataggatg tcttaggccc taattcacca tttctttttt aagatctgat atgctatcat   1620

tgccttaata atggaacaaa atagaagcat atctaacact ttttaaattg ataattttgt   1680

aaaattgatt acgttgaatg ctttttaaga gaagtgtgta aagtttttat attttcacaa   1740

ttaacgtatg taaaaccttg tatcagaaat ttatcatgtt tactgtttaa aatgattgta   1800

tttataaaat tgtcaatatc ttaatgtatt taatgtagaa tattgctttt taaaataatg   1860

tttttatttt gctgtagaaa aataaaaaaa aatttgatta taaaaaaaaa aaaaaaaaaa   1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                                 1952


<210>  948
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  948

Met Ser Ala Ala Cys Trp Glu Glu Pro Trp Gly Leu Pro Gly Gly Phe 
1               5                   10                  15


Ala Lys Arg Val Leu Val Thr Gly Gly Ala Gly Phe Ile Ala Ser His 
            20                  25                  30


Met Ile Val Ser Leu Val Glu Asp Tyr Pro Asn Tyr Met Ile Ile Asn 
        35                  40                  45


Leu Asp Lys Leu Asp Tyr Cys Ala Ser Leu Lys Asn Leu Glu Thr Ile 
    50                  55                  60


Ser Asn Lys Gln Asn Tyr Lys Phe Ile Gln Gly Asp Ile Cys Asp Ser 
65                  70                  75                  80


His Phe Val Lys Leu Leu Phe Glu Thr Glu Lys Ile Asp Ile Val Leu 
                85                  90                  95


His Phe Ala Ala Gln Thr His Val Asp Leu Ser Phe Val Arg Ala Phe 
            100                 105                 110


Glu Phe Thr Tyr Val Asn Val Tyr Gly Thr His Val Leu Val Ser Ala 
        115                 120                 125


Ala His Glu Ala Arg Val Glu Lys Phe Ile Tyr Val Ser Thr Asp Glu 
    130                 135                 140


Val Tyr Gly Gly Ser Leu Asp Lys Glu Phe Asp Glu Ser Ser Pro Lys 
145                 150                 155                 160


Gln Pro Thr Asn Pro Tyr Ala Ser Ser Lys Ala Ala Ala Glu Cys Phe 
                165                 170                 175


Val Gln Ser Tyr Trp Glu Gln Tyr Lys Phe Pro Val Val Ile Thr Arg 
            180                 185                 190


Ser Ser Asn Val Tyr Gly Pro His Gln Tyr Pro Glu Lys Val Ile Pro 
        195                 200                 205


Lys Phe Ile Ser Leu Leu Gln His Asn Arg Lys Cys Cys Ile His Gly 
    210                 215                 220


Ser Gly Leu Gln Thr Arg Asn Phe Leu Tyr Ala Thr Asp Val Val Glu 
225                 230                 235                 240


Ala Phe Leu Thr Val Leu Lys Lys Gly Lys Pro Gly Glu Ile Tyr Asn 
                245                 250                 255


Ile Gly Thr Asn Phe Glu Met Ser Val Val Gln Leu Ala Lys Glu Leu 
            260                 265                 270


Ile Gln Leu Ile Lys Glu Thr Asn Ser Glu Ser Glu Met Glu Asn Trp 
        275                 280                 285


Val Asp Tyr Val Asn Asp Arg Pro Thr Asn Asp Met Arg Tyr Pro Met 
    290                 295                 300


Lys Ser Glu Lys Ile His Gly Leu Gly Trp Arg Pro Lys Val Pro Trp 
305                 310                 315                 320


Lys Glu Gly Ile Lys Lys Thr Ile Glu Trp Tyr Arg Glu Asn Phe His 
                325                 330                 335


Asn Trp Lys Asn Val Glu Lys Ala Leu Glu Pro Phe Pro Val 
            340                 345                 350


<210>  949
<211>  3922
<212>  DNA
<213>  Homo sapiens

<400>  949
ctcccccagc tgccgacgtg gggcgggcag ccgccggcgg ctgggagccg aggcgtcggt     60

gcagacctgg agacgggcat gggggggctg cggctgctgg ctgtggccct cacgtgctgc    120

tggtggccgc agggcagcca gggtaagacc ctgcggggca gcttcagcag caccgcggcc    180

caggacgccc agggccagcg catcggccac ttcgagttcc atggtgacca tgctcttctg    240

tgtgtcagaa tcaacaacat agcagtagct gttggaaaag aagctaaact ctacctgttc    300

caagcccagg aatggctaaa gctacagcaa agcagtcatg gttatagctg tagtgaaaaa    360

ttatccaaag ctcagttgac aatgaccatg aaccagaccg aacataatct gacagtgtcc    420

cagattccgt ctccacaaac gtggcatgtg ttttatgcag acaagtatac atgccaagat    480

gacaaggaga attctcaggt ggaagatatc ccatttgaaa tggtgttact aaacccagat    540

gccgaaggga atccatttga tcattttagt gctggagaat ctgggttaca tgagttcttt    600

ttcctcctag tcctagtgta ctttgtgatt gcttgcattt atgctcaatc attgtggcag    660

gctattaaga aaggcggacc catgcacatg attttaaagg ttctgacaac tgcattgctg    720

ttacaagctg gttcagcttt agctaattac attcatttct ccagttactc caaagatgga    780

ataggggtac catttatggg aagtttggca gaattttttg acatcgcttc ccaaattcag    840

atgttatact tacttttgag tctatgcatg ggttggacaa tagtcagaat gaagaagtct    900

caaagcagac ctctccagtg ggattctacg cctgcatcca ctggcattgc agtattcatt    960

gtcatgacac agagtgtttt gctactttgg gaacagtttg aagatatcag tcatcatagc   1020

taccattcac accacaactt agcagggatc ctcctaattg ttctaagaat ttgcctagca   1080

ttgtcattag gctgtggact ctatcagatc atcacagtgg agagaagtac actcaaaagg   1140

gagttctaca tcacatttgc caaaggctgt atcttgtggt ttttatgcca tccagttctt   1200

gcatgcattt ctgtcatttt tagcgactac caaagagaca aggttattac aataggtgtt   1260

atcctttgcc agtctgtttc catggttatt ctctacagac tctttctgtc tcacagtcta   1320

tactgggaag tttcttcact ttcttcagta acactaccac tgaccatatc atctggacac   1380

aaaagtcgcc ctcatttctg atacttgatt tttgttgaga ggaaaagtga attggttaaa   1440

agagtgcaat aaggatccaa atacagtgac ttttttttca tacatttagt atgaaaactt   1500

gaacagcgaa agcagagcat gttatttata taactgcatt taagcagtac caagactgaa   1560

aaaaaaggta ataaatgaaa tgttttgaaa tatacttaaa caacaaactt tgaagaaagt   1620

gttgttataa aattattgaa gcgatttcta tgtggaaata aatgtgaaaa ataactatga   1680

tattttggta aaatattcac cacttataat gcctcatctt aatagctaac tcaggtttaa   1740

tagtcttata aaaagtaatc agttaaatga ttacttgctt ataaatatct aaactagtcc   1800

agttatgaaa tcagtgtaat acattgattt ttaaaactgc tgctttttat gctttaagga   1860

aaatgtattt catatttgag tttaaaggaa ttgaaattac ttcaggaaat gaatataaaa   1920

taggttcaca gttaaatgaa taagcttttg tttatttgtg ggtggagtta ttctccaatt   1980

ttttctgcca tttttggctc tagttcaggt tttagcttga ttagcaaagg tttttgacaa   2040

acagtttatg aaaaaataaa acttaaatac attacacggg ttgtaaggac aaaggatttt   2100

aaaatctgag cacttaggtg aagggacaag caggtttatg tgtttaaaca gaaagaaggg   2160

aaaaggtact atgtgatatg gtactgaaat tttgatccca atagaattca tttctcttac   2220

gttgaatccc caatcataat taagccgtat acacagatta aattaacaga agcatttcac   2280

ataaatgttg gtttcagtca tcaactaccc atgaattcct gcccaaggat acttaatcag   2340

gattaaattt tctatgaata attgaaaaac aaaacactca ctggatttgt tataatccgt   2400

gttggcactg gattctaagt agttgccatc ttgaatcctt tgtaataaag ccatactttt   2460

gtgtgtgtgt gtgatgcccc agtattgagt atgctagcta aaaaatatca agtgcctgat   2520

taaagaattg ctaaatggtt gtcaatactc gctgtataaa atgagtattc ccattaatag   2580

tcactgattg gaaattattc tgttgctgtt tgtcaagctg ttcaggcctt ttccttttta   2640

cttctggctt attttaaaaa tattttttat ctatttactg tgtgtttaag caagcaacag   2700

tgcactgatc tggtagttaa attttttaat taaatagtta aaataatgta gtgcaactta   2760

aaaatatcta tggctttgtt tttgtttttc ttttgtacct agtctcattg gaaatgacta   2820

gtattctgcc tcattttcag ggcagaatat gtgtttgtga cccaaaatga caaagttacc   2880

aagttcaacc tgctcattaa atcatctctc tattagttct ttgtaaatca cttagtacat   2940

tagagctaca ggttaagact agaaagtctg agttatgttt taggtataca tgatcgtctg   3000

agtggtcata accttttctt ttatcatgtc tcgctaataa ccccagctat tgtctgttgt   3060

gttcagctga gatgcaaaaa agaaattaag caaaaaagaa aaagatgaag acttttcatg   3120

aattttgtga acttgccaaa aggggaaggg aaaaatcttt gtgttacttc actcaaagaa   3180

cataagtaac tgcaattaac atatatgaaa tttattactc tgcttgcatt tatgaaacta   3240

accagttttt taaactttaa ttcttaaatt tatggttgga aatgctgata atttattttg   3300

ttatttaaga gctgttgtta agtggaggaa agtagttgtt aataaatgta taaaactgtt   3360

cttgactagt aatcagggac aaaatttata gttcataagt catgacacag tattcgctct   3420

ttttctgaat gtttacatag agattcatca ctgcagatta cagaaagtta agtgtatact   3480

acaaactcta attaaagata aaaatctttt ctacttttct ttgtcagata atgctttttt   3540

atgtgttttt acattttttg aaagaagata aatggttcat ccagagcttt attaagaagc   3600

atttcttttc ttcccttaaa aaatagatgc ttatttttat tgacatgtgt ataataagat   3660

gggtgcctac tgtgatgcat tttaccaggc attttacctt cattattact catctctatt   3720

gtgataacca ggctcccatt taactgagta taagagagaa taaatgattt ctctaaggtc   3780

atcaaactat ttagtttttc cactttacct tcatgattta aggaacatgt attagctgtg   3840

ttttagtgag aatgaattgc tatccatcat aatttttgct gttgatttga acattaaaac   3900

tggaattgtg ctaaaatcag aa                                            3922


<210>  950
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  950

Met Gly Gly Leu Arg Leu Leu Ala Val Ala Leu Thr Cys Cys Trp Trp 
1               5                   10                  15


Pro Gln Gly Ser Gln Gly Lys Thr Leu Arg Gly Ser Phe Ser Ser Thr 
            20                  25                  30


Ala Ala Gln Asp Ala Gln Gly Gln Arg Ile Gly His Phe Glu Phe His 
        35                  40                  45


Gly Asp His Ala Leu Leu Cys Val Arg Ile Asn Asn Ile Ala Val Ala 
    50                  55                  60


Val Gly Lys Glu Ala Lys Leu Tyr Leu Phe Gln Ala Gln Glu Trp Leu 
65                  70                  75                  80


Lys Leu Gln Gln Ser Ser His Gly Tyr Ser Cys Ser Glu Lys Leu Ser 
                85                  90                  95


Lys Ala Gln Leu Thr Met Thr Met Asn Gln Thr Glu His Asn Leu Thr 
            100                 105                 110


Val Ser Gln Ile Pro Ser Pro Gln Thr Trp His Val Phe Tyr Ala Asp 
        115                 120                 125


Lys Tyr Thr Cys Gln Asp Asp Lys Glu Asn Ser Gln Val Glu Asp Ile 
    130                 135                 140


Pro Phe Glu Met Val Leu Leu Asn Pro Asp Ala Glu Gly Asn Pro Phe 
145                 150                 155                 160


Asp His Phe Ser Ala Gly Glu Ser Gly Leu His Glu Phe Phe Phe Leu 
                165                 170                 175


Leu Val Leu Val Tyr Phe Val Ile Ala Cys Ile Tyr Ala Gln Ser Leu 
            180                 185                 190


Trp Gln Ala Ile Lys Lys Gly Gly Pro Met His Met Ile Leu Lys Val 
        195                 200                 205


Leu Thr Thr Ala Leu Leu Leu Gln Ala Gly Ser Ala Leu Ala Asn Tyr 
    210                 215                 220


Ile His Phe Ser Ser Tyr Ser Lys Asp Gly Ile Gly Val Pro Phe Met 
225                 230                 235                 240


Gly Ser Leu Ala Glu Phe Phe Asp Ile Ala Ser Gln Ile Gln Met Leu 
                245                 250                 255


Tyr Leu Leu Leu Ser Leu Cys Met Gly Trp Thr Ile Val Arg Met Lys 
            260                 265                 270


Lys Ser Gln Ser Arg Pro Leu Gln Trp Asp Ser Thr Pro Ala Ser Thr 
        275                 280                 285


Gly Ile Ala Val Phe Ile Val Met Thr Gln Ser Val Leu Leu Leu Trp 
    290                 295                 300


Glu Gln Phe Glu Asp Ile Ser His His Ser Tyr His Ser His His Asn 
305                 310                 315                 320


Leu Ala Gly Ile Leu Leu Ile Val Leu Arg Ile Cys Leu Ala Leu Ser 
                325                 330                 335


Leu Gly Cys Gly Leu Tyr Gln Ile Ile Thr Val Glu Arg Ser Thr Leu 
            340                 345                 350


Lys Arg Glu Phe Tyr Ile Thr Phe Ala Lys Gly Cys Ile Leu Trp Phe 
        355                 360                 365


Leu Cys His Pro Val Leu Ala Cys Ile Ser Val Ile Phe Ser Asp Tyr 
    370                 375                 380


Gln Arg Asp Lys Val Ile Thr Ile Gly Val Ile Leu Cys Gln Ser Val 
385                 390                 395                 400


Ser Met Val Ile Leu Tyr Arg Leu Phe Leu Ser His Ser Leu Tyr Trp 
                405                 410                 415


Glu Val Ser Ser Leu Ser Ser Val Thr Leu Pro Leu Thr Ile Ser Ser 
            420                 425                 430


Gly His Lys Ser Arg Pro His Phe 
        435                 440


<210>  951
<211>  5843
<212>  DNA
<213>  Homo sapiens

<400>  951
gagcggacag gcgtggcggc cggagcccca gcatccctgc ttgaggtcca ggagcggagc     60

ccgcggccac cgccgcctga tcagcgcgac cccggcccgc gcccgccccg cccggcaaga    120

tgctgcccgt gtaccaggag gtgaagccca acccgctgca ggacgcgaac ctctgctcac    180

gcgtgttctt ctggtggctc aatcccttgt ttaaaattgg ccataaacgg agattagagg    240

aagatgatat gtattcagtg ctgccagaag accgctcaca gcaccttgga gaggagttgc    300

aagggttctg ggataaagaa gttttaagag ctgagaatga cgcacagaag ccttctttaa    360

caagagcaat cataaagtgt tactggaaat cttatttagt tttgggaatt tttacgttaa    420

ttgaggaaag tgccaaagta atccagccca tatttttggg aaaaattatt aattattttg    480

aaaattatga tcccatggat tctgtggctt tgaacacagc gtacgcctat gccacggtgc    540

tgactttttg cacgctcatt ttggctatac tgcatcactt atatttttat cacgttcagt    600

gtgctgggat gaggttacga gtagccatgt gccatatgat ttatcggaag gcacttcgtc    660

ttagtaacat ggccatgggg aagacaacca caggccagat agtcaatctg ctgtccaatg    720

atgtgaacaa gtttgatcag gtgacagtgt tcttacactt cctgtgggca ggaccactgc    780

aggcgattgc agtgactgcc ctactctgga tggagatagg aatatcgtgc cttgctggga    840

tggcagttct aatcattctc ctgcccttgc aaagctgttt tgggaagttg ttctcatcac    900

tgaggagtaa aactgcaact ttcacggatg ccaggatcag gaccatgaat gaagttataa    960

ctggtataag gataataaaa atgtacgcct gggaaaagtc attttcaaat cttattacca   1020

atttgagaaa gaaggagatt tccaagattc tgagaagttc ctgcctcaga gggatgaatt   1080

tggcttcatt tttcagtgca agcaaaatca tcgtgtttgt gaccttcacc acctacgtgc   1140

tcctcggcag tgtgatcaca gccagccgcg tgttcgtggc agtgacgctg tatggggctg   1200

tgcggctgac ggttaccctc ttcttcccct cagccattga gagggtgtca gaggcaatcg   1260

tcagcatccg aagaatccag acctttttgc tacttgatga gatatcacag cgcaaccgtc   1320

agctgccgtc agatggtaaa aagatggtgc atgtgcagga ttttactgct ttttgggata   1380

aggcatcaga gaccccaact ctacaaggcc tttcctttac tgtcagacct ggcgaattgt   1440

tagctgtggt cggccccgtg ggagcaggga agtcatcact gttaagtgcc gtgctcgggg   1500

aattggcccc aagtcacggg ctggtcagcg tgcatggaag aattgcctat gtgtctcagc   1560

agccctgggt gttctcggga actctgagga gtaatatttt atttgggaag aaatacgaaa   1620

aggaacgata tgaaaaagtc ataaaggctt gtgctctgaa aaaggattta cagctgttgg   1680

aggatggtga tctgactgtg ataggagatc ggggaaccac gctgagtgga gggcagaaag   1740

cacgggtaaa ccttgcaaga gcagtgtatc aagatgctga catctatctc ctggacgatc   1800

ctctcagtgc agtagatgcg gaagttagca gacacttgtt cgaactgtgt atttgtcaaa   1860

ttttgcatga gaagatcaca attttagtga ctcatcagtt gcagtacctc aaagctgcaa   1920

gtcagattct gatattgaaa gatggtaaaa tggtgcagaa ggggacttac actgagttcc   1980

taaaatctgg tatagatttt ggctcccttt taaagaagga taatgaggaa agtgaacaac   2040

ctccagttcc aggaactccc acactaagga atcgtacctt ctcagagtct tcggtttggt   2100

ctcaacaatc ttctagaccc tccttgaaag atggtgctct ggagagccaa gatacagaga   2160

atgtcccagt tacactatca gaggagaacc gttctgaagg aaaagttggt tttcaggcct   2220

ataagaatta cttcagagct ggtgctcact ggattgtctt cattttcctt attctcctaa   2280

acactgcagc tcaggttgcc tatgtgcttc aagattggtg gctttcatac tgggcaaaca   2340

aacaaagtat gctaaatgtc actgtaaatg gaggaggaaa tgtaaccgag aagctagatc   2400

ttaactggta cttaggaatt tattcaggtt taactgtagc taccgttctt tttggcatag   2460

caagatctct attggtattc tacgtccttg ttaactcttc acaaactttg cacaacaaaa   2520

tgtttgagtc aattctgaaa gctccggtat tattctttga tagaaatcca ataggaagaa   2580

ttttaaatcg tttctccaaa gacattggac acttggatga tttgctgccg ctgacgtttt   2640

tagatttcat ccagacattg ctacaagtgg ttggtgtggt ctctgtggct gtggccgtga   2700

ttccttggat cgcaataccc ttggttcccc ttggaatcat tttcattttt cttcggcgat   2760

attttttgga aacgtcaaga gatgtgaagc gcctggaatc tacaactcgg agtccagtgt   2820

tttcccactt atcatcttct ctccaggggc tctggaccat ccgggcatac aaagcagaag   2880

agaggtgtca ggaactgttt gatgcacacc aggatttaca ttcagaggct tggttcttgt   2940

ttttgacaac gtcccgctgg tttgccgtcc gtctggatgc catctgtgcc atgtttgtca   3000

tcatcgttgc ctttgggtcc ctgattctgg caaaaactct ggatgccggg caggttggtt   3060

tggcactgtc ctatgccctc acgctcatgg ggatgtttca gtggtgtgtt cgacaaagtg   3120

ctgaagttga gaatatgatg atctcagtag aaagggtcat tgaatacaca gaccttgaaa   3180

aagaagcacc ttgggaatat cagaaacgcc caccaccagc ctggccccat gaaggagtga   3240

taatctttga caatgtgaac ttcatgtaca gtccaggtgg gcctctggta ctgaagcatc   3300

tgacagcact cattaaatca caagaaaagg ttggcattgt gggaagaacc ggagctggaa   3360

aaagttccct catctcagcc ctttttagat tgtcagaacc cgaaggtaaa atttggattg   3420

ataagatctt gacaactgaa attggacttc acgatttaag gaagaagatg tcaatcatac   3480

ctcaggaacc tgttttgttc actggaacaa tgaggaaaaa cctggatccc tttaatgagc   3540

acacggatga ggaactgtgg aatgccttac aagaggtaca acttaaagaa accattgaag   3600

atcttcctgg taaaatggat actgaattag cagaatcagg atccaatttt agtgttggac   3660

aaagacaact ggtgtgcctt gccagggcaa ttctcaggaa aaatcagata ttgattattg   3720

atgaagcgac ggcaaatgtg gatccaagaa ctgatgagtt aatacaaaaa aaaatccggg   3780

agaaatttgc ccactgcacc gtgctaacca ttgcacacag attgaacacc attattgaca   3840

gcgacaagat aatggtttta gattcaggaa gactgaaaga atatgatgag ccgtatgttt   3900

tgctgcaaaa taaagagagc ctattttaca agatggtgca acaactgggc aaggcagaag   3960

ccgctgccct cactgaaaca gcaaaacagg tatacttcaa aagaaattat ccacatattg   4020

gtcacactga ccacatggtt acaaacactt ccaatggaca gccctcgacc ttaactattt   4080

tcgagacagc actgtgaatc caaccaaaat gtcaagtccg ttccgaaggc attttccact   4140

agtttttgga ctatgtaaac cacattgtac ttttttttac tttggcaaca aatatttata   4200

catacaagat gctagttcat ttgaatattt ctcccaactt atccaaggat ctccagctct   4260

aacaaaatgg tttattttta tttaaatgtc aatagttgtt ttttaaaatc caaatcagag   4320

gtgcaggcca ccagttaaat gccgtctatc aggttttgtg ccttaagaga ctacagagtc   4380

aaagctcatt tttaaaggag taggacaaag ttgtcacagg tttttgttgt tgtttttatt   4440

gcccccaaaa ttacatgtta atttccattt atatcaggga ttctatttac ttgaagactg   4500

tgaagttgcc attttgtctc attgttttct ttgacataac taggatccat tatttcccct   4560

gaaggcttct tgttagaaaa tagtacagtt acaaccaata ggaacaacaa aaagaaaaag   4620

tttgtgacat tgtagtaggg agtgtgtacc ccttactccc catcaaaaaa aaaaatggat   4680

acatggttaa aggatagaag ggcaatattt tatcatatgt tctaaaagag aaggaagaga   4740

aaatactact ttctcaaaat ggaagccctt aaaggtgctt tgatactgaa ggacacaaat   4800

gtgaccgtcc atcctccttt agagttgcat gacttggaca cggtaactgt tgcagtttta   4860

gactcagcat tgtgacactt cccaagaagg ccaaacctct aaccgacatt cctgaaatac   4920

gtggcattat tcttttttgg atttctcatt tatggaaggc taaccctctg ttgactgtaa   4980

gccttttggt ttgggctgta ttgaaatcct ttctaaattg catgaatagg ctctgctaac   5040

gtgatgagac aaactgaaaa ttattgcaag cattgactat aattatgcag tacgttctca   5100

ggatgcatcc aggggttcat tttcatgagc ctgtccaggt tagtttactc ctgaccacta   5160

atagcattgt catttgggct ttctgttgaa tgaatcaaca aaccacaata cttcctggga   5220

ccttttgtac tttatttgaa ctatgagtct ttaatttttc ctgatgatgg tggctgtaat   5280

atgttgagtt cagtttacta aaggttttac tattatggtt tgaagtggag tctcatgacc   5340

tctcagaata aggtgtcacc tccctgaaat tgcatatatg tatatagaca tgcacacgtg   5400

tgcatttgtt tgtatacata tatttgtcct tcgtatagca agttttttgc tcatcagcag   5460

agagcaacag atgttttatt gagtgaagcc ttaaaaagca cacaccacac acagctaact   5520

gccaaaatac attgaccgta gtagctgttc aactcctagt acttagaaat acacgtatgg   5580

ttaatgttca gtccaacaaa ccacacacag taaatgttta ttaatagtca tggttcgtat   5640

tttaggtgac tgaaattgca tcagtgatca taatgaggtt tgttaaaacg atagctatat   5700

tcaaaatgtc tatatgttta tttggacttt tgaggttaaa gacagtcata taaacgtcct   5760

gtttctgttt taatgttatc atagaatttt ttaatgaaac taaattcaat tgaaataaat   5820

gatagttttc atctccattc aga                                           5843


<210>  952
<211>  1325
<212>  PRT
<213>  Homo sapiens

<400>  952

Met Leu Pro Val Tyr Gln Glu Val Lys Pro Asn Pro Leu Gln Asp Ala 
1               5                   10                  15


Asn Leu Cys Ser Arg Val Phe Phe Trp Trp Leu Asn Pro Leu Phe Lys 
            20                  25                  30


Ile Gly His Lys Arg Arg Leu Glu Glu Asp Asp Met Tyr Ser Val Leu 
        35                  40                  45


Pro Glu Asp Arg Ser Gln His Leu Gly Glu Glu Leu Gln Gly Phe Trp 
    50                  55                  60


Asp Lys Glu Val Leu Arg Ala Glu Asn Asp Ala Gln Lys Pro Ser Leu 
65                  70                  75                  80


Thr Arg Ala Ile Ile Lys Cys Tyr Trp Lys Ser Tyr Leu Val Leu Gly 
                85                  90                  95


Ile Phe Thr Leu Ile Glu Glu Ser Ala Lys Val Ile Gln Pro Ile Phe 
            100                 105                 110


Leu Gly Lys Ile Ile Asn Tyr Phe Glu Asn Tyr Asp Pro Met Asp Ser 
        115                 120                 125


Val Ala Leu Asn Thr Ala Tyr Ala Tyr Ala Thr Val Leu Thr Phe Cys 
    130                 135                 140


Thr Leu Ile Leu Ala Ile Leu His His Leu Tyr Phe Tyr His Val Gln 
145                 150                 155                 160


Cys Ala Gly Met Arg Leu Arg Val Ala Met Cys His Met Ile Tyr Arg 
                165                 170                 175


Lys Ala Leu Arg Leu Ser Asn Met Ala Met Gly Lys Thr Thr Thr Gly 
            180                 185                 190


Gln Ile Val Asn Leu Leu Ser Asn Asp Val Asn Lys Phe Asp Gln Val 
        195                 200                 205


Thr Val Phe Leu His Phe Leu Trp Ala Gly Pro Leu Gln Ala Ile Ala 
    210                 215                 220


Val Thr Ala Leu Leu Trp Met Glu Ile Gly Ile Ser Cys Leu Ala Gly 
225                 230                 235                 240


Met Ala Val Leu Ile Ile Leu Leu Pro Leu Gln Ser Cys Phe Gly Lys 
                245                 250                 255


Leu Phe Ser Ser Leu Arg Ser Lys Thr Ala Thr Phe Thr Asp Ala Arg 
            260                 265                 270


Ile Arg Thr Met Asn Glu Val Ile Thr Gly Ile Arg Ile Ile Lys Met 
        275                 280                 285


Tyr Ala Trp Glu Lys Ser Phe Ser Asn Leu Ile Thr Asn Leu Arg Lys 
    290                 295                 300


Lys Glu Ile Ser Lys Ile Leu Arg Ser Ser Cys Leu Arg Gly Met Asn 
305                 310                 315                 320


Leu Ala Ser Phe Phe Ser Ala Ser Lys Ile Ile Val Phe Val Thr Phe 
                325                 330                 335


Thr Thr Tyr Val Leu Leu Gly Ser Val Ile Thr Ala Ser Arg Val Phe 
            340                 345                 350


Val Ala Val Thr Leu Tyr Gly Ala Val Arg Leu Thr Val Thr Leu Phe 
        355                 360                 365


Phe Pro Ser Ala Ile Glu Arg Val Ser Glu Ala Ile Val Ser Ile Arg 
    370                 375                 380


Arg Ile Gln Thr Phe Leu Leu Leu Asp Glu Ile Ser Gln Arg Asn Arg 
385                 390                 395                 400


Gln Leu Pro Ser Asp Gly Lys Lys Met Val His Val Gln Asp Phe Thr 
                405                 410                 415


Ala Phe Trp Asp Lys Ala Ser Glu Thr Pro Thr Leu Gln Gly Leu Ser 
            420                 425                 430


Phe Thr Val Arg Pro Gly Glu Leu Leu Ala Val Val Gly Pro Val Gly 
        435                 440                 445


Ala Gly Lys Ser Ser Leu Leu Ser Ala Val Leu Gly Glu Leu Ala Pro 
    450                 455                 460


Ser His Gly Leu Val Ser Val His Gly Arg Ile Ala Tyr Val Ser Gln 
465                 470                 475                 480


Gln Pro Trp Val Phe Ser Gly Thr Leu Arg Ser Asn Ile Leu Phe Gly 
                485                 490                 495


Lys Lys Tyr Glu Lys Glu Arg Tyr Glu Lys Val Ile Lys Ala Cys Ala 
            500                 505                 510


Leu Lys Lys Asp Leu Gln Leu Leu Glu Asp Gly Asp Leu Thr Val Ile 
        515                 520                 525


Gly Asp Arg Gly Thr Thr Leu Ser Gly Gly Gln Lys Ala Arg Val Asn 
    530                 535                 540


Leu Ala Arg Ala Val Tyr Gln Asp Ala Asp Ile Tyr Leu Leu Asp Asp 
545                 550                 555                 560


Pro Leu Ser Ala Val Asp Ala Glu Val Ser Arg His Leu Phe Glu Leu 
                565                 570                 575


Cys Ile Cys Gln Ile Leu His Glu Lys Ile Thr Ile Leu Val Thr His 
            580                 585                 590


Gln Leu Gln Tyr Leu Lys Ala Ala Ser Gln Ile Leu Ile Leu Lys Asp 
        595                 600                 605


Gly Lys Met Val Gln Lys Gly Thr Tyr Thr Glu Phe Leu Lys Ser Gly 
    610                 615                 620


Ile Asp Phe Gly Ser Leu Leu Lys Lys Asp Asn Glu Glu Ser Glu Gln 
625                 630                 635                 640


Pro Pro Val Pro Gly Thr Pro Thr Leu Arg Asn Arg Thr Phe Ser Glu 
                645                 650                 655


Ser Ser Val Trp Ser Gln Gln Ser Ser Arg Pro Ser Leu Lys Asp Gly 
            660                 665                 670


Ala Leu Glu Ser Gln Asp Thr Glu Asn Val Pro Val Thr Leu Ser Glu 
        675                 680                 685


Glu Asn Arg Ser Glu Gly Lys Val Gly Phe Gln Ala Tyr Lys Asn Tyr 
    690                 695                 700


Phe Arg Ala Gly Ala His Trp Ile Val Phe Ile Phe Leu Ile Leu Leu 
705                 710                 715                 720


Asn Thr Ala Ala Gln Val Ala Tyr Val Leu Gln Asp Trp Trp Leu Ser 
                725                 730                 735


Tyr Trp Ala Asn Lys Gln Ser Met Leu Asn Val Thr Val Asn Gly Gly 
            740                 745                 750


Gly Asn Val Thr Glu Lys Leu Asp Leu Asn Trp Tyr Leu Gly Ile Tyr 
        755                 760                 765


Ser Gly Leu Thr Val Ala Thr Val Leu Phe Gly Ile Ala Arg Ser Leu 
    770                 775                 780


Leu Val Phe Tyr Val Leu Val Asn Ser Ser Gln Thr Leu His Asn Lys 
785                 790                 795                 800


Met Phe Glu Ser Ile Leu Lys Ala Pro Val Leu Phe Phe Asp Arg Asn 
                805                 810                 815


Pro Ile Gly Arg Ile Leu Asn Arg Phe Ser Lys Asp Ile Gly His Leu 
            820                 825                 830


Asp Asp Leu Leu Pro Leu Thr Phe Leu Asp Phe Ile Gln Thr Leu Leu 
        835                 840                 845


Gln Val Val Gly Val Val Ser Val Ala Val Ala Val Ile Pro Trp Ile 
    850                 855                 860


Ala Ile Pro Leu Val Pro Leu Gly Ile Ile Phe Ile Phe Leu Arg Arg 
865                 870                 875                 880


Tyr Phe Leu Glu Thr Ser Arg Asp Val Lys Arg Leu Glu Ser Thr Thr 
                885                 890                 895


Arg Ser Pro Val Phe Ser His Leu Ser Ser Ser Leu Gln Gly Leu Trp 
            900                 905                 910


Thr Ile Arg Ala Tyr Lys Ala Glu Glu Arg Cys Gln Glu Leu Phe Asp 
        915                 920                 925


Ala His Gln Asp Leu His Ser Glu Ala Trp Phe Leu Phe Leu Thr Thr 
    930                 935                 940


Ser Arg Trp Phe Ala Val Arg Leu Asp Ala Ile Cys Ala Met Phe Val 
945                 950                 955                 960


Ile Ile Val Ala Phe Gly Ser Leu Ile Leu Ala Lys Thr Leu Asp Ala 
                965                 970                 975


Gly Gln Val Gly Leu Ala Leu Ser Tyr Ala Leu Thr Leu Met Gly Met 
            980                 985                 990


Phe Gln Trp Cys Val Arg Gln Ser Ala Glu Val Glu Asn Met Met Ile 
        995                 1000                1005


Ser Val Glu Arg Val Ile Glu Tyr Thr Asp Leu Glu Lys Glu Ala Pro 
    1010                1015                1020


Trp Glu Tyr Gln Lys Arg Pro Pro Pro Ala Trp Pro His Glu Gly Val 
1025                1030                1035                1040


Ile Ile Phe Asp Asn Val Asn Phe Met Tyr Ser Pro Gly Gly Pro Leu 
                1045                1050                1055


Val Leu Lys His Leu Thr Ala Leu Ile Lys Ser Gln Glu Lys Val Gly 
            1060                1065                1070


Ile Val Gly Arg Thr Gly Ala Gly Lys Ser Ser Leu Ile Ser Ala Leu 
        1075                1080                1085


Phe Arg Leu Ser Glu Pro Glu Gly Lys Ile Trp Ile Asp Lys Ile Leu 
    1090                1095                1100


Thr Thr Glu Ile Gly Leu His Asp Leu Arg Lys Lys Met Ser Ile Ile 
1105                1110                1115                1120


Pro Gln Glu Pro Val Leu Phe Thr Gly Thr Met Arg Lys Asn Leu Asp 
                1125                1130                1135


Pro Phe Asn Glu His Thr Asp Glu Glu Leu Trp Asn Ala Leu Gln Glu 
            1140                1145                1150


Val Gln Leu Lys Glu Thr Ile Glu Asp Leu Pro Gly Lys Met Asp Thr 
        1155                1160                1165


Glu Leu Ala Glu Ser Gly Ser Asn Phe Ser Val Gly Gln Arg Gln Leu 
    1170                1175                1180


Val Cys Leu Ala Arg Ala Ile Leu Arg Lys Asn Gln Ile Leu Ile Ile 
1185                1190                1195                1200


Asp Glu Ala Thr Ala Asn Val Asp Pro Arg Thr Asp Glu Leu Ile Gln 
                1205                1210                1215


Lys Lys Ile Arg Glu Lys Phe Ala His Cys Thr Val Leu Thr Ile Ala 
            1220                1225                1230


His Arg Leu Asn Thr Ile Ile Asp Ser Asp Lys Ile Met Val Leu Asp 
        1235                1240                1245


Ser Gly Arg Leu Lys Glu Tyr Asp Glu Pro Tyr Val Leu Leu Gln Asn 
    1250                1255                1260


Lys Glu Ser Leu Phe Tyr Lys Met Val Gln Gln Leu Gly Lys Ala Glu 
1265                1270                1275                1280


Ala Ala Ala Leu Thr Glu Thr Ala Lys Gln Val Tyr Phe Lys Arg Asn 
                1285                1290                1295


Tyr Pro His Ile Gly His Thr Asp His Met Val Thr Asn Thr Ser Asn 
            1300                1305                1310


Gly Gln Pro Ser Thr Leu Thr Ile Phe Glu Thr Ala Leu 
        1315                1320                1325


<210>  953
<211>  3149
<212>  DNA
<213>  Homo sapiens

<400>  953
cgcttccggg agagtccgcg tctcccgcac cttcctctct atcaaacgcc gtctctgtgg     60

tagccggggc cccgcccctc ctcggactct acccagtact gaactagggg cagctgggct    120

ccagagtccc tcgggtctca ggtcatggcg gtcgcggggc ccgcgcccgg agctggcgcc    180

aggcccaggt tagatctgca atttctccag cggttcctgc agatactgaa ggttttgttt    240

ccttcttggt catcacaaaa tgccttgatg ttcctgaccc ttttgtgcct gaccctactg    300

gagcaatttg tgatctacca ggttggcttg atccccagtc agtactatgg ggtcctggga    360

aacaaagact tggaagggtt taagactctg acattcctgg ctgtcatgct cattgttctg    420

aactccacgc tgaagagctt tgatcagttc acctgcaacc tgctgtatgt gagctggagg    480

aaggacctca ctgagcacct tcaccgcctc tacttccggg gccgtgcgta ctacaccctc    540

aacgtgctgc gggatgacat cgataacccg gaccagcgca tcagccagga cgtggagcga    600

ttctgccggc agctcagcag catggccagc aagctcatca tctccccgtt caccctcgtc    660

tactacactt accagtgctt ccaaagcaca ggctggctcg ggcctgtgag catcttcggg    720

tatttcatcc tggggaccgt ggtgaacaaa actttgatgg gccccattgt gatgaagctg    780

gtgcatcagg agaagctgga gggagatttt aggttcaagc acatgcagat tcgggtgaat    840

gcggagcctg ctgctttcta cagagctggg catgtggagc acatgaggac agaccgcagg    900

ctgcagagac tccttcagac ccagagggag ctgatgtcca aggagctctg gctgtacatc    960

ggcatcaaca cctttgacta tctgggcagc atcctgagtt acgttgtcat cgcaatcccc   1020

attttcagcg gggtctatgg agacctgagt cccgcagagc ttagcaccct ggtcagcaag   1080

aatgcctttg tgtgcatcta cctcatcagc tgcttcaccc agctcatcga cctgtccacg   1140

acgctctcag atgtggctgg ctacacgcac agaattgggc agcttcggga gacgcttctg   1200

gacatgtccc tgaagtcaca ggactgcgag atcctgggcg agagcgagtg gggcttggac   1260

acacccccag ggtggccagc ggcagagcca gcagacacag catttctcct tgagcgggtc   1320

tccatctctg ccccctcctc tgacaaaccc ctaatcaagg atctgagcct aaagatctcc   1380

gagggacaga gcctgctcat cacaggcaac acgggcactg gcaagacctc cttgctccgg   1440

gttctgggtg gcctctggac gagtacacgg ggctcagtgc agatgctgac ggactttggg   1500

ccccatgggg tgctattcct gccacaaaag ccattcttca ctgacgggac ccttcgggag   1560

caggtgatat atcccctgaa ggaggtctac cccgactcag gttctgccga tgatgagagg   1620

atcttgaggt tcttggaatt ggcaggcctg tccaacttgg tggcaaggac agagggcctg   1680

gaccagcagg tggactggaa ctggtatgat gttctgtccc cgggggagat gcaacggctc   1740

tcctttgccc gactcttcta cctgcagccg aagtacgcag tgcttgatga agccaccagt   1800

gccctgacag aggaagtgga gagcgagctc tatcgcatcg gccagcagct ggggatgacg   1860

ttcatcagtg tgggacatcg gcagagcctt gagaagtttc attccttggt tctgaaactc   1920

tgtggaggag gaagatggga gctgatgaga atcaaagtgg aatgaagctc tggcttttgg   1980

aaggagagcc acactgtggc gggtcggcgg ccctcaggag agaccaggag gactgacagc   2040

gaagatcgag ctcaggttcg ccacatagat cccgtgcagg agccacatgg gtcctgtgca   2100

ggacccctag cagtggtggg ctgagcccag gtctaggttt ctgtggggga cactgaatct   2160

cccagtgttc agtctcccag gactctgctg cctcagccag agcctccata tgcttgaagt   2220

gctgattacc tacaaatgat ttcagatcat gtttgctaaa gagaaatctg gaagtgtgag   2280

atctgtaaga aatgaaagaa atgactcttg gagtcaagag atctggaaat cttttaatca   2340

gttaaattgt gcagcaatag atttttaact ttaactgacc atttaagttt tttaataagt   2400

tttttacaaa gaaaagttaa acattaaaaa gaattacagc tttctgtctt ctctatcatg   2460

gaatgatctt ttttattgaa tctccagatt tgtatttgac agcttggtgg gaagggaagc   2520

acactctgct gttctggaat cttatgccca gggtttttca cttctcccca catctccctt   2580

tccacttgcc agtgttgtgt agttagaacc tgaaccacta acttccaggg gcctttggtc   2640

tgccctacct taacccaaat gaaagtaaat ccctttcccc ttagccaaaa taaggttggg   2700

ttttctaaaa aaatagtcta tattagggaa caacaacagc aaattagaca aaacccagaa   2760

agcacaaagc atgaggtgga gttactgtgc ccaaagtcct cactcagacc agtgcccctc   2820

cagttcagtt gtctatgtat taccttcctt accttcataa tttttgccag gcttctgtac   2880

ttctagtact tgagttactt aatattttta aaaacaaacc ttttaagttt aaatggattt   2940

ttaagtgaaa ttttacactt aacatagatg gaaagtaact aaaaataaat acaagaaaaa   3000

ccatcggtgt tattaactta cggctagatg ctgttgcctg catagactct gggcctgagg   3060

cttgttcatt ttgtaaaaaa gagaggtgag gagttagacg gactggcact caactgagat   3120

ttttctcctt aataaaatca gaaagatgg                                     3149


<210>  954
<211>  606
<212>  PRT
<213>  Homo sapiens

<400>  954

Met Ala Val Ala Gly Pro Ala Pro Gly Ala Gly Ala Arg Pro Arg Leu 
1               5                   10                  15


Asp Leu Gln Phe Leu Gln Arg Phe Leu Gln Ile Leu Lys Val Leu Phe 
            20                  25                  30


Pro Ser Trp Ser Ser Gln Asn Ala Leu Met Phe Leu Thr Leu Leu Cys 
        35                  40                  45


Leu Thr Leu Leu Glu Gln Phe Val Ile Tyr Gln Val Gly Leu Ile Pro 
    50                  55                  60


Ser Gln Tyr Tyr Gly Val Leu Gly Asn Lys Asp Leu Glu Gly Phe Lys 
65                  70                  75                  80


Thr Leu Thr Phe Leu Ala Val Met Leu Ile Val Leu Asn Ser Thr Leu 
                85                  90                  95


Lys Ser Phe Asp Gln Phe Thr Cys Asn Leu Leu Tyr Val Ser Trp Arg 
            100                 105                 110


Lys Asp Leu Thr Glu His Leu His Arg Leu Tyr Phe Arg Gly Arg Ala 
        115                 120                 125


Tyr Tyr Thr Leu Asn Val Leu Arg Asp Asp Ile Asp Asn Pro Asp Gln 
    130                 135                 140


Arg Ile Ser Gln Asp Val Glu Arg Phe Cys Arg Gln Leu Ser Ser Met 
145                 150                 155                 160


Ala Ser Lys Leu Ile Ile Ser Pro Phe Thr Leu Val Tyr Tyr Thr Tyr 
                165                 170                 175


Gln Cys Phe Gln Ser Thr Gly Trp Leu Gly Pro Val Ser Ile Phe Gly 
            180                 185                 190


Tyr Phe Ile Leu Gly Thr Val Val Asn Lys Thr Leu Met Gly Pro Ile 
        195                 200                 205


Val Met Lys Leu Val His Gln Glu Lys Leu Glu Gly Asp Phe Arg Phe 
    210                 215                 220


Lys His Met Gln Ile Arg Val Asn Ala Glu Pro Ala Ala Phe Tyr Arg 
225                 230                 235                 240


Ala Gly His Val Glu His Met Arg Thr Asp Arg Arg Leu Gln Arg Leu 
                245                 250                 255


Leu Gln Thr Gln Arg Glu Leu Met Ser Lys Glu Leu Trp Leu Tyr Ile 
            260                 265                 270


Gly Ile Asn Thr Phe Asp Tyr Leu Gly Ser Ile Leu Ser Tyr Val Val 
        275                 280                 285


Ile Ala Ile Pro Ile Phe Ser Gly Val Tyr Gly Asp Leu Ser Pro Ala 
    290                 295                 300


Glu Leu Ser Thr Leu Val Ser Lys Asn Ala Phe Val Cys Ile Tyr Leu 
305                 310                 315                 320


Ile Ser Cys Phe Thr Gln Leu Ile Asp Leu Ser Thr Thr Leu Ser Asp 
                325                 330                 335


Val Ala Gly Tyr Thr His Arg Ile Gly Gln Leu Arg Glu Thr Leu Leu 
            340                 345                 350


Asp Met Ser Leu Lys Ser Gln Asp Cys Glu Ile Leu Gly Glu Ser Glu 
        355                 360                 365


Trp Gly Leu Asp Thr Pro Pro Gly Trp Pro Ala Ala Glu Pro Ala Asp 
    370                 375                 380


Thr Ala Phe Leu Leu Glu Arg Val Ser Ile Ser Ala Pro Ser Ser Asp 
385                 390                 395                 400


Lys Pro Leu Ile Lys Asp Leu Ser Leu Lys Ile Ser Glu Gly Gln Ser 
                405                 410                 415


Leu Leu Ile Thr Gly Asn Thr Gly Thr Gly Lys Thr Ser Leu Leu Arg 
            420                 425                 430


Val Leu Gly Gly Leu Trp Thr Ser Thr Arg Gly Ser Val Gln Met Leu 
        435                 440                 445


Thr Asp Phe Gly Pro His Gly Val Leu Phe Leu Pro Gln Lys Pro Phe 
    450                 455                 460


Phe Thr Asp Gly Thr Leu Arg Glu Gln Val Ile Tyr Pro Leu Lys Glu 
465                 470                 475                 480


Val Tyr Pro Asp Ser Gly Ser Ala Asp Asp Glu Arg Ile Leu Arg Phe 
                485                 490                 495


Leu Glu Leu Ala Gly Leu Ser Asn Leu Val Ala Arg Thr Glu Gly Leu 
            500                 505                 510


Asp Gln Gln Val Asp Trp Asn Trp Tyr Asp Val Leu Ser Pro Gly Glu 
        515                 520                 525


Met Gln Arg Leu Ser Phe Ala Arg Leu Phe Tyr Leu Gln Pro Lys Tyr 
    530                 535                 540


Ala Val Leu Asp Glu Ala Thr Ser Ala Leu Thr Glu Glu Val Glu Ser 
545                 550                 555                 560


Glu Leu Tyr Arg Ile Gly Gln Gln Leu Gly Met Thr Phe Ile Ser Val 
                565                 570                 575


Gly His Arg Gln Ser Leu Glu Lys Phe His Ser Leu Val Leu Lys Leu 
            580                 585                 590


Cys Gly Gly Gly Arg Trp Glu Leu Met Arg Ile Lys Val Glu 
        595                 600                 605


<210>  955
<211>  3464
<212>  DNA
<213>  Homo sapiens

<400>  955
caccggccag ttggctgtag acggtccatg ctcaatggtc ctctacagat atgaaactgg     60

ttctggagtg agacgagctc ggctggggac gctacttgag aaggcctttc cccacagggt    120

gacttaaatg tcccaggctg gaaggtggag cgagaagtgg atgcccccag ggctctgggt    180

cacactccag gatgacttct cggaaccagc tggtgcagaa ggtgctgcag gagctgcagg    240

aagcagtgga gtgcgaaggc ctggagggtc tcataggtgc ttccttggag gccaagcagg    300

tcctgtcttc cttcactctc cccacctgcc gggagggagg ccctggcctc caggtgctgg    360

aagtggactc ggtggccctg agcctgtatc cagaagatgc tccacggaac atgctgccgc    420

tggtgtgcaa gggggagggc agcctgctgt tcgaggcggc cagcatgctg ctgtggggtg    480

acgcaggcct cagcctggag ctgcgggccc gcaccgtggt agagatgctg ctgcacagac    540

actactacct ccagggcatg atcgactcca aagtgatgct gcaggccgtg cgctactccc    600

tatgctctga ggagtcccct gagatgacca gcttgccccc cgccacgctg gaggccatct    660

tcgatgccga cgtcaaggcc tcctgtttcc ccagcagctt ctccaacgtg tggcacttgt    720

atgctctcgc ctctgtcctc cagcggaaca tctactccat ctaccccatg cgcaacctca    780

agatccggcc ctacttcaac cgtgtcatcc ggccccgccg ctgcgaccac gtgccctcca    840

cgctgcacat catgtgggct ggccagcccc tcaccagcca cttcttccgc caccagtact    900

ttgcccctgt ggtggggctg gaagaggtgg aggctgaagg tgcccctggc gtggccccag    960

ctcttccagc cctggcccca ctctcatcgc cggccaagac cctggagctg ctcaaccgtg   1020

aacctggcct cagctactct cacctctgtg agcgctacag cgtcaccaaa agcaccttct   1080

accgctggcg gcggcagtcc caggagcacc ggcagaaggt tgctgcccgc ttctccgcca   1140

agcacttcct gcaggacagc ttccaccggg ggggcgtcgt gccacttcag cagttcctcc   1200

agcggttccc ggagatctcc cgctcaacct actatgcctg gaagcatgag ctgctgggct   1260

ctggcacctg cccggccttg ccccccaggg aggtgctggg catggaggag ctagagaagc   1320

tgccggagga gcaggtggct gaggaggagc tggagtgctc cgcactggcg gtgtcaagcc   1380

ctggaatggt cttaatgcag cgggccaagt tgtacctgga gcattgcatc tccctgaaca   1440

cactggtacc ctatcgctgc ttcaaacgca ggttccctgg catctcacgg tccacttatt   1500

ataattggcg gcgaaaggcc ctccggagga accccagctt caagccggca ccagccctct   1560

ctgctgctgg gactccccag ctagcatctg ttggggaagg ggctgtaatt ccttggaaga   1620

gtgaggcgga agagggggca gggaatgcca caggtgagga ccctcccgcc cccggggagc   1680

tcctgccact aaggatgccc ctgtcccgtt ggcagaggcg tctgcgcagg gctgcccgca   1740

ggcaggtgct gagtgggcat ctccctttct gccgcttccg cctccgctac cccagcctgt   1800

caccttctgc cttttgggtc tggaagagtc ttgctcgggg ttggcccaga ggcctgtcca   1860

aacttcaggt gccggtcccc accttgggca aaggggggca ggaggctgag gagaagcagg   1920

agaaggaggc tggcagggat gtgacagctg tgatggcccc acctgtgggg gcttcttcag   1980

aagatgtaga gggagggcct tccagagagg gggccctgca ggagggggcc acagcccagg   2040

gccagcccca cagtgggccc ttgctgagcc aacctgtggt ggcagcagcg ggtggcaggg   2100

atggccggat gctggtgatg gacatgatcg ctaccacgaa gttcaaggcc caggccaagc   2160

tgttcttgca gaagcgcttc cagtccaaga gctttccctc ctacaaggag ttcagtgccc   2220

tctttcccct cactgcccgc tccacatact acatgtggaa gcgagccctc tatgacggcc   2280

tgaccctggt agatggctga cagggaggta caaaaggggc tgggaagaag ggggaccagt   2340

ttggagaggg tcagggacct gagctgaccc caggcttggc caggatgtcc tttgctctgg   2400

gtcccacagt gtctacccta agtccaaggg tatatttgtg ttattttctg gctccaggac   2460

agagaatgcc agaaatcagc catctggtct cccgtaggaa actgtgggac cagagatatc   2520

ctctttcgtt gtttgctggt catattttta ctgttatgat ttagtttttg gttttgattt   2580

gagtgggttg gttggccccc ttgctggagt tggaagccgt atgtatgtca gggggtttag   2640

aggggggttg gttagctaga gctgctttca gcttttcctg gagacaaaag gagtgttata   2700

gcatgatcat cggtcccact gggcagaacg ttatcttcag tttcttttgg gggttggcat   2760

cctctttact cagttgtttc ccaaaggaac attaggctcg aatatggggg ccaggtgtgg   2820

tggcttatgc ctgtaatcct agcgctttgg gaggccaagg caggaggatc acttgaggct   2880

aggagttaga gaccaccctg ggcaatgtag tgagacctca tctcttagaa aaaaaaaaag   2940

aaagaaaatc aaatgtagag ctgatcagca gcttgtgcct ggcatcccca agggagaagg   3000

tgccaggtca gcaggagcag cagcagggat gtatagaaag aaccacagct ggcctctaaa   3060

ggatggcact gaggcaccgg agatcttgag gcactggaga tcactgaggg gctggcctgt   3120

cccctgcaag gagtgtggga ccaggtgggg caaggctggg agatgcaggc tctgtttgca   3180

gattatggcc cagagtctct gcttgtgggt gcttgatcca cctgctggga ccctgcagtc   3240

ctcggccagc ctggctgtca gttggggatt ccacctttct gctgagcgtc ttctcggagc   3300

tggaggccca tcttcagtga gagatcacaa agcggccagg caggtgggag actgaatttg   3360

ccttgttcga gagtaacgtt tgaaaaccaa agaaataaag tgatgcagtg cccacaaaaa   3420

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                    3464


<210>  956
<211>  702
<212>  PRT
<213>  Homo sapiens

<400>  956

Met Thr Ser Arg Asn Gln Leu Val Gln Lys Val Leu Gln Glu Leu Gln 
1               5                   10                  15


Glu Ala Val Glu Cys Glu Gly Leu Glu Gly Leu Ile Gly Ala Ser Leu 
            20                  25                  30


Glu Ala Lys Gln Val Leu Ser Ser Phe Thr Leu Pro Thr Cys Arg Glu 
        35                  40                  45


Gly Gly Pro Gly Leu Gln Val Leu Glu Val Asp Ser Val Ala Leu Ser 
    50                  55                  60


Leu Tyr Pro Glu Asp Ala Pro Arg Asn Met Leu Pro Leu Val Cys Lys 
65                  70                  75                  80


Gly Glu Gly Ser Leu Leu Phe Glu Ala Ala Ser Met Leu Leu Trp Gly 
                85                  90                  95


Asp Ala Gly Leu Ser Leu Glu Leu Arg Ala Arg Thr Val Val Glu Met 
            100                 105                 110


Leu Leu His Arg His Tyr Tyr Leu Gln Gly Met Ile Asp Ser Lys Val 
        115                 120                 125


Met Leu Gln Ala Val Arg Tyr Ser Leu Cys Ser Glu Glu Ser Pro Glu 
    130                 135                 140


Met Thr Ser Leu Pro Pro Ala Thr Leu Glu Ala Ile Phe Asp Ala Asp 
145                 150                 155                 160


Val Lys Ala Ser Cys Phe Pro Ser Ser Phe Ser Asn Val Trp His Leu 
                165                 170                 175


Tyr Ala Leu Ala Ser Val Leu Gln Arg Asn Ile Tyr Ser Ile Tyr Pro 
            180                 185                 190


Met Arg Asn Leu Lys Ile Arg Pro Tyr Phe Asn Arg Val Ile Arg Pro 
        195                 200                 205


Arg Arg Cys Asp His Val Pro Ser Thr Leu His Ile Met Trp Ala Gly 
    210                 215                 220


Gln Pro Leu Thr Ser His Phe Phe Arg His Gln Tyr Phe Ala Pro Val 
225                 230                 235                 240


Val Gly Leu Glu Glu Val Glu Ala Glu Gly Ala Pro Gly Val Ala Pro 
                245                 250                 255


Ala Leu Pro Ala Leu Ala Pro Leu Ser Ser Pro Ala Lys Thr Leu Glu 
            260                 265                 270


Leu Leu Asn Arg Glu Pro Gly Leu Ser Tyr Ser His Leu Cys Glu Arg 
        275                 280                 285


Tyr Ser Val Thr Lys Ser Thr Phe Tyr Arg Trp Arg Arg Gln Ser Gln 
    290                 295                 300


Glu His Arg Gln Lys Val Ala Ala Arg Phe Ser Ala Lys His Phe Leu 
305                 310                 315                 320


Gln Asp Ser Phe His Arg Gly Gly Val Val Pro Leu Gln Gln Phe Leu 
                325                 330                 335


Gln Arg Phe Pro Glu Ile Ser Arg Ser Thr Tyr Tyr Ala Trp Lys His 
            340                 345                 350


Glu Leu Leu Gly Ser Gly Thr Cys Pro Ala Leu Pro Pro Arg Glu Val 
        355                 360                 365


Leu Gly Met Glu Glu Leu Glu Lys Leu Pro Glu Glu Gln Val Ala Glu 
    370                 375                 380


Glu Glu Leu Glu Cys Ser Ala Leu Ala Val Ser Ser Pro Gly Met Val 
385                 390                 395                 400


Leu Met Gln Arg Ala Lys Leu Tyr Leu Glu His Cys Ile Ser Leu Asn 
                405                 410                 415


Thr Leu Val Pro Tyr Arg Cys Phe Lys Arg Arg Phe Pro Gly Ile Ser 
            420                 425                 430


Arg Ser Thr Tyr Tyr Asn Trp Arg Arg Lys Ala Leu Arg Arg Asn Pro 
        435                 440                 445


Ser Phe Lys Pro Ala Pro Ala Leu Ser Ala Ala Gly Thr Pro Gln Leu 
    450                 455                 460


Ala Ser Val Gly Glu Gly Ala Val Ile Pro Trp Lys Ser Glu Ala Glu 
465                 470                 475                 480


Glu Gly Ala Gly Asn Ala Thr Gly Glu Asp Pro Pro Ala Pro Gly Glu 
                485                 490                 495


Leu Leu Pro Leu Arg Met Pro Leu Ser Arg Trp Gln Arg Arg Leu Arg 
            500                 505                 510


Arg Ala Ala Arg Arg Gln Val Leu Ser Gly His Leu Pro Phe Cys Arg 
        515                 520                 525


Phe Arg Leu Arg Tyr Pro Ser Leu Ser Pro Ser Ala Phe Trp Val Trp 
    530                 535                 540


Lys Ser Leu Ala Arg Gly Trp Pro Arg Gly Leu Ser Lys Leu Gln Val 
545                 550                 555                 560


Pro Val Pro Thr Leu Gly Lys Gly Gly Gln Glu Ala Glu Glu Lys Gln 
                565                 570                 575


Glu Lys Glu Ala Gly Arg Asp Val Thr Ala Val Met Ala Pro Pro Val 
            580                 585                 590


Gly Ala Ser Ser Glu Asp Val Glu Gly Gly Pro Ser Arg Glu Gly Ala 
        595                 600                 605


Leu Gln Glu Gly Ala Thr Ala Gln Gly Gln Pro His Ser Gly Pro Leu 
    610                 615                 620


Leu Ser Gln Pro Val Val Ala Ala Ala Gly Gly Arg Asp Gly Arg Met 
625                 630                 635                 640


Leu Val Met Asp Met Ile Ala Thr Thr Lys Phe Lys Ala Gln Ala Lys 
                645                 650                 655


Leu Phe Leu Gln Lys Arg Phe Gln Ser Lys Ser Phe Pro Ser Tyr Lys 
            660                 665                 670


Glu Phe Ser Ala Leu Phe Pro Leu Thr Ala Arg Ser Thr Tyr Tyr Met 
        675                 680                 685


Trp Lys Arg Ala Leu Tyr Asp Gly Leu Thr Leu Val Asp Gly 
    690                 695                 700


<210>  957
<211>  5333
<212>  DNA
<213>  Homo sapiens

<400>  957
ctgtcactgc agcctggcgg cctgagcgcc gagcctgggg ctggggccgc ggtgctgagg     60

acgcaaatca gccccgtagc tgggtggagc ctccgggcct gacgtggatc ttcactggag    120

aagtgactca gggatcctcc caggatgtct gcctcaccag acaacctgag tacaggggga    180

aggttacaga acatgacagt ggatgaatgc ctccagtctc ggaacaccgt cctccagggg    240

cagccctttg ggggtgtccc caccgtgctg tgcctcaaca tcgccctgtg ggtgctcgtc    300

cttgtggttt actccttcct ccggaaagct gcgtgggact atgggcgcct ggctctgctg    360

atacacaatg acagcctgac ctcgctgatc tatggggagc agagcgagaa gacatctccc    420

tcggagactt ccttggagat ggaacgcaga gacaagggat tctgttcctg gttcttcaac    480

agcataacaa tgaaggacga ggatctgatt aacaagtgtg gggacgacgc gcgcatctac    540

atcgtgttcc agtaccacct catcatcttt gtgctcatca tctgtatccc ctccctgggc    600

atcattttgc ccatcaacta tactggatct gttctggact ggagcagtca ctttgctcgg    660

accaccattg tcaatgtctc cacagagagc aagctcctgt ggctgcatag cctgctgtcc    720

ttcttctact tcatcaccaa cttcatgttc atggctcatc actgcctggg gtttgcgccc    780

aggaatagcc aaaaggtcac aaggacacta atgatcacct atgtgcccaa ggacattgaa    840

gacccagaac tcatcattaa gcattttcac gaggcctatc caggcagtgt cgtgacaaga    900

gtccacttct gctacgacgt caggaacctg atcgacttgg acgatcagag gcgccatgcc    960

atgcggggcc ggcttttcta tacagccaag gccaagaaga ctgggaaggt gatgatcagg   1020

atccacccct gtgcccgcct gtgcttctgc aagtgctgga cctgcttcaa ggaggtggat   1080

gcagagcagt attacagcga gctagaggag cagctaacgg acgagttcaa cgccgagctc   1140

aaccgcgtgc cgctcaagcg gctggacctg atctttgtca ccttccagga ctccaggatg   1200

gccaagcgtg tccgtaagga ttacaagtat gtccagtgtg gtgtgcaacc ccagcagtcc   1260

tcagtgacca ccatcgtcaa atcatattac tggagggtca ctatggcccc acaccccaaa   1320

gacattattt ggaaacacct gtctgtccgc cgcttctttt ggtgggcccg ctttatcgca   1380

atcaacacct tcctcttctt cctcttcttc tttctcacca cgcctgccat catcatgaac   1440

actatcgaca tgtacaacgt cacccgcccc atcgagaagc tgcagaaccc aattgtgacc   1500

cagttcttcc cctctgtgat gctctggggc ttcacagtga tactgcctct gattgtctac   1560

ttctccgcct tcctcgaggc ccactggacc agatcaagtc agaatctggt catggtgcac   1620

aagtgctaca tctttctggt gttcatggta gtcattctgc cctctatggg actgaccagt   1680

ttggatgtct ttctccgctg gctctttgac atctactatc tagagcaagc atccatcagg   1740

ttccagtgtg tgttcctgcc agacaacggc gccttctttg tcaactacgt gatcacggca   1800

gctttacttg gcacaggcat ggagctgctg cgtctggggt cactcttctg ctacagcacc   1860

cgcctcttct tctctagatc agagccagag agagtcaaca tcagaaagaa ccaggccata   1920

gacttccagt ttgggcgtga gtatgcgtgg atgatgaacg tgttcagcgt ggtgatggcg   1980

tacagcatca cttgccccat cattgtgcct tttgggttgc tctacctgtg catgaagcac   2040

ttgacggatc gctataacat gtactactcc tttgcaccca ccaaactgaa cgagcagatc   2100

cacatggctg ccgtctccca ggccatcttt gcgccactct tgggtctgtt ctggatgctg   2160

ttcttctcca tcctgcggtt gggttctctc cacgccatca ccatcttttc cctgtccacc   2220

ctcctcattg ccatggtgat tgcctttgtt ggcatttttc tggggaagct tcggatggtt   2280

gccgactacg agcccgagga ggaggagatc cagacagtgt ttgacatgga gccaagcagc   2340

acctcctcca cgcccacctc cctcctgtat gtggccaccg tgctgcaaga accggagttg   2400

aatctgaccc ccgcctcctc cccagccagg cacacctatg gcaccatgaa caaccagccg   2460

gaagagggag aagaagagag tggtctgagg ggctttgcga gggagctaga ctcggcccag   2520

ttccaggaag ggctggaact ggagggccag aaccagtacc actgaccggg acctgaggcc   2580

tccactggcg acttgttgag gggtcagggg agggcctggc aaggggaggc aggagggtgg   2640

cctggacctc cccactacct cctgcagact ttgagaagcc tacagtggag acatccacca   2700

ccccagccat gggccatacg ggggtcctga cctgctgccc ggctggaact ggggctgctc   2760

ggcagtgctg aaggagcctg ggaagggatg ggaggataca ggcaagcaca tgtcttgaga   2820

gaggtggctg gagccccggc acagagactg aacgctgggg tcccttcctg ggaccaagat   2880

ggagaaggtg ttcctaaggg aggagacaga aggaggctgc cgaaggctct gtggggtcat   2940

caccactctg catcagctgc ccttaaaagg agcttctgct gctgctcctc ctcccagccc   3000

cggcccattc ctcccctgca gtctgaggag gcaaaggtat gtgcacgggg cacattgaca   3060

ggacacggag gaccacctca tcacagggtt ccctgcatgg ggatctgtaa agagaaagtt   3120

tctgcaccca ccagagcaag agccaactga aagcgtagac ctgagaagag gtaactcagc   3180

cccttcctgc tcctctgccc tcatcagatg tccccaggag cagcagggca gaggcccttc   3240

tttctattct tacaagggta gctagagcgt gatcactcag ggctcatcaa atgagactcg   3300

tgtgcatttt tcagaaggaa accttggtta gtccttgctg ggtaacacaa agtggggtga   3360

gacgacagaa gccgaattca tggaaggggg gtcttctccc caaaactctg tgtggtggga   3420

aaccagctat acctccccaa gccccagggc ctaaagagaa gacccccgaa gccaaagatg   3480

tggccactta aaagcgtctc ctgcctccta cccaactgag tgcctgggcc cccagcttgg   3540

ccaagatggg cagtacgtta gggtaagaac cccatgcttc aaacttaagg actgaccatc   3600

acctgcgtcc caagtaggac ccttcctccc ttctcggggc tgcccctgca ccctgccttg   3660

aagaccaccc aagcggcctc cagtgtgggc ctggtccaga cattgcagat gcttcaaccg   3720

tgatgtcgcc ccaggcctgc caggggtgtg gtggagggga aggccacgtg ctccagggag   3780

aagccctttc tggagaagca aggctgtcct cccagggctg ccactaccag agacctgggg   3840

gagctgaatt ccgaacagtg atggtgacac tcagcacctt tgccacagcc ggggggaacc   3900

ggcttctgcc tctgggatgg gctctcatca gggccaccgt gcagcccagc cagggaggac   3960

atgagaaggg ccagtggggg cctcaatgaa ccagaacaag ccaagctgaa tggggtctgt   4020

gtgctccagg gccctcttca gccccctccc ccaaaggtct gggtccctgc caccaaccta   4080

ctgaaggccg gcccccggct cacctcacct gagcacctgc accaggcccc aggcacatgg   4140

ctgccctgaa ctcagatcac ctagaccttg tccctgcccc acctttgccc catcctagcc   4200

ccagaagctc caagcttcac cgcaggtgag aaattgtgct caatgggcag aaactgctat   4260

acccccaggg catggcccac attttggcat gagggtgtct ttccagagag cttgggttgg   4320

ctggagagag gctgtctttc ccattccttg tccagctagg aataaagggg aaatggtcct   4380

agcctggccc ctacacaccc aggtcccaca ggccccctcc ccactggaat ttcaccaacc   4440

aacaagggga aagtacgctg ttacagcata gcggtcaggc ccagcaggag cttggcacat   4500

gatggggagg tggccagctc caggccctgc ccgaccccat catgtgtatt tggtgtatgg   4560

ggtgtggggg tcacaccaga agctggcctg gggtctcttc tttgctggac acagctccct   4620

ggcccctgcc cccagcccct gcagcccctg ccggactgtg gaagccacat atgggaaaag   4680

tcctggcaga caatgtggcg ggatgactgg gggcttctcc ctctgaacct gggtccagtg   4740

tagcctggct ctgagagaag gtggtgagca tgtggagaag gttccatagt ccactcttag   4800

gggaaccagc aaagcctcat ggcagttggc tccatctgga cctcccatgg tcactacagg   4860

atggtggagc agggggcatc ttttagcctc cccccgccac cacatccagg ccctctcagg   4920

cacctcctgc ctcagcccac acctgcctca cccattgccc ccctcccccc acctactgcc   4980

atcccactcc tctgccagcc acttcccagc cgccccaccc cactccatcc accaaatcac   5040

ctcctgactt aatcctttct ggaaggagct gccgcccagg aaccggtatt gcctagagcc   5100

tccaggaggg gccctcctca ggcctccagt ggccccatgc ccacctgcct gaccctccac   5160

tgcccctgga agcaaagtgc ctatcagcag cgttgcgtcc tctggggccc ccggtcgggg   5220

gggagggggt gtgggctaac cttggccacc accacaaaag gaatgtgcca gaatgctgaa   5280

ccttcttgtt aatgctatga ccgtgccttg aataaacaag tcctcccaac ctc          5333


<210>  958
<211>  806
<212>  PRT
<213>  Homo sapiens

<400>  958

Met Ser Ala Ser Pro Asp Asn Leu Ser Thr Gly Gly Arg Leu Gln Asn 
1               5                   10                  15


Met Thr Val Asp Glu Cys Leu Gln Ser Arg Asn Thr Val Leu Gln Gly 
            20                  25                  30


Gln Pro Phe Gly Gly Val Pro Thr Val Leu Cys Leu Asn Ile Ala Leu 
        35                  40                  45


Trp Val Leu Val Leu Val Val Tyr Ser Phe Leu Arg Lys Ala Ala Trp 
    50                  55                  60


Asp Tyr Gly Arg Leu Ala Leu Leu Ile His Asn Asp Ser Leu Thr Ser 
65                  70                  75                  80


Leu Ile Tyr Gly Glu Gln Ser Glu Lys Thr Ser Pro Ser Glu Thr Ser 
                85                  90                  95


Leu Glu Met Glu Arg Arg Asp Lys Gly Phe Cys Ser Trp Phe Phe Asn 
            100                 105                 110


Ser Ile Thr Met Lys Asp Glu Asp Leu Ile Asn Lys Cys Gly Asp Asp 
        115                 120                 125


Ala Arg Ile Tyr Ile Val Phe Gln Tyr His Leu Ile Ile Phe Val Leu 
    130                 135                 140


Ile Ile Cys Ile Pro Ser Leu Gly Ile Ile Leu Pro Ile Asn Tyr Thr 
145                 150                 155                 160


Gly Ser Val Leu Asp Trp Ser Ser His Phe Ala Arg Thr Thr Ile Val 
                165                 170                 175


Asn Val Ser Thr Glu Ser Lys Leu Leu Trp Leu His Ser Leu Leu Ser 
            180                 185                 190


Phe Phe Tyr Phe Ile Thr Asn Phe Met Phe Met Ala His His Cys Leu 
        195                 200                 205


Gly Phe Ala Pro Arg Asn Ser Gln Lys Val Thr Arg Thr Leu Met Ile 
    210                 215                 220


Thr Tyr Val Pro Lys Asp Ile Glu Asp Pro Glu Leu Ile Ile Lys His 
225                 230                 235                 240


Phe His Glu Ala Tyr Pro Gly Ser Val Val Thr Arg Val His Phe Cys 
                245                 250                 255


Tyr Asp Val Arg Asn Leu Ile Asp Leu Asp Asp Gln Arg Arg His Ala 
            260                 265                 270


Met Arg Gly Arg Leu Phe Tyr Thr Ala Lys Ala Lys Lys Thr Gly Lys 
        275                 280                 285


Val Met Ile Arg Ile His Pro Cys Ala Arg Leu Cys Phe Cys Lys Cys 
    290                 295                 300


Trp Thr Cys Phe Lys Glu Val Asp Ala Glu Gln Tyr Tyr Ser Glu Leu 
305                 310                 315                 320


Glu Glu Gln Leu Thr Asp Glu Phe Asn Ala Glu Leu Asn Arg Val Pro 
                325                 330                 335


Leu Lys Arg Leu Asp Leu Ile Phe Val Thr Phe Gln Asp Ser Arg Met 
            340                 345                 350


Ala Lys Arg Val Arg Lys Asp Tyr Lys Tyr Val Gln Cys Gly Val Gln 
        355                 360                 365


Pro Gln Gln Ser Ser Val Thr Thr Ile Val Lys Ser Tyr Tyr Trp Arg 
    370                 375                 380


Val Thr Met Ala Pro His Pro Lys Asp Ile Ile Trp Lys His Leu Ser 
385                 390                 395                 400


Val Arg Arg Phe Phe Trp Trp Ala Arg Phe Ile Ala Ile Asn Thr Phe 
                405                 410                 415


Leu Phe Phe Leu Phe Phe Phe Leu Thr Thr Pro Ala Ile Ile Met Asn 
            420                 425                 430


Thr Ile Asp Met Tyr Asn Val Thr Arg Pro Ile Glu Lys Leu Gln Asn 
        435                 440                 445


Pro Ile Val Thr Gln Phe Phe Pro Ser Val Met Leu Trp Gly Phe Thr 
    450                 455                 460


Val Ile Leu Pro Leu Ile Val Tyr Phe Ser Ala Phe Leu Glu Ala His 
465                 470                 475                 480


Trp Thr Arg Ser Ser Gln Asn Leu Val Met Val His Lys Cys Tyr Ile 
                485                 490                 495


Phe Leu Val Phe Met Val Val Ile Leu Pro Ser Met Gly Leu Thr Ser 
            500                 505                 510


Leu Asp Val Phe Leu Arg Trp Leu Phe Asp Ile Tyr Tyr Leu Glu Gln 
        515                 520                 525


Ala Ser Ile Arg Phe Gln Cys Val Phe Leu Pro Asp Asn Gly Ala Phe 
    530                 535                 540


Phe Val Asn Tyr Val Ile Thr Ala Ala Leu Leu Gly Thr Gly Met Glu 
545                 550                 555                 560


Leu Leu Arg Leu Gly Ser Leu Phe Cys Tyr Ser Thr Arg Leu Phe Phe 
                565                 570                 575


Ser Arg Ser Glu Pro Glu Arg Val Asn Ile Arg Lys Asn Gln Ala Ile 
            580                 585                 590


Asp Phe Gln Phe Gly Arg Glu Tyr Ala Trp Met Met Asn Val Phe Ser 
        595                 600                 605


Val Val Met Ala Tyr Ser Ile Thr Cys Pro Ile Ile Val Pro Phe Gly 
    610                 615                 620


Leu Leu Tyr Leu Cys Met Lys His Leu Thr Asp Arg Tyr Asn Met Tyr 
625                 630                 635                 640


Tyr Ser Phe Ala Pro Thr Lys Leu Asn Glu Gln Ile His Met Ala Ala 
                645                 650                 655


Val Ser Gln Ala Ile Phe Ala Pro Leu Leu Gly Leu Phe Trp Met Leu 
            660                 665                 670


Phe Phe Ser Ile Leu Arg Leu Gly Ser Leu His Ala Ile Thr Ile Phe 
        675                 680                 685


Ser Leu Ser Thr Leu Leu Ile Ala Met Val Ile Ala Phe Val Gly Ile 
    690                 695                 700


Phe Leu Gly Lys Leu Arg Met Val Ala Asp Tyr Glu Pro Glu Glu Glu 
705                 710                 715                 720


Glu Ile Gln Thr Val Phe Asp Met Glu Pro Ser Ser Thr Ser Ser Thr 
                725                 730                 735


Pro Thr Ser Leu Leu Tyr Val Ala Thr Val Leu Gln Glu Pro Glu Leu 
            740                 745                 750


Asn Leu Thr Pro Ala Ser Ser Pro Ala Arg His Thr Tyr Gly Thr Met 
        755                 760                 765


Asn Asn Gln Pro Glu Glu Gly Glu Glu Glu Ser Gly Leu Arg Gly Phe 
    770                 775                 780


Ala Arg Glu Leu Asp Ser Ala Gln Phe Gln Glu Gly Leu Glu Leu Glu 
785                 790                 795                 800


Gly Gln Asn Gln Tyr His 
                805


<210>  959
<211>  1885
<212>  DNA
<213>  Homo sapiens

<400>  959
ttcccaggcc accatagcgg ctggcggagg gagcgcgcgc cttgctggcc tggagggggc     60

gggggccgtg gcggctttaa agcgcccagc ccaggcgtcg cggggtgggg cggctctggc    120

ggctgcgggg cgcagggcgc agcggccaag cggggtcccc ggaagcacag ctggggtgtc    180

tccacctacg actggccgcg cgccttttct ctcccgcgcc agggaaggag cggctgcggc    240

ccccgccggg cggaggcacg gggggcgtac gaggggcgga ggggaccgcg tcgcggagga    300

gatggcgcgg cacgtgcggt gacggcaccc gagccctgag ggtcccagcc ccgcgctccg    360

cgtccccggg acagcatgga gcgcccggag cccgagctga tccggcagag ctggcgggca    420

gtgagccgca gcccgctgga gcacggcacc gtcctgtttg ccaggctgtt tgccctggag    480

cctgacctgc tgcccctctt ccagtacaac tgccgccagt tctccagccc agaggactgt    540

ctctcctcgc ctgagttcct ggaccacatc aggaaggtga tgctcgtgat tgatgctgca    600

gtgaccaatg tggaagacct gtcctcactg gaggagtacc ttgccagcct gggcaggaag    660

caccgggcag tgggtgtgaa gctcagctcc ttctcgacag tgggtgagtc tctgctctac    720

atgctggaga agtgtctggg ccctgccttc acaccagcca cacgggctgc ctggagccaa    780

ctctacgggg ccgtagtgca ggccatgagt cgaggctggg atggcgagta agaggcgacc    840

ccgcccggca gcccccatcc atctgtgtct gtctgttggc ctgtatctgt tgtagcccag    900

gctccccaag cttccctgca tcttggtcct tgtccccttg gccacactgg agaggtgatg    960

gggcagggct gggtctcagt atcctagagt ccagctgcag aaggagtggc ttttcctcca   1020

ggaaggggct tctgggtgtc ccctcatccc cagtagcctc tttcttgcgt ttctttttac   1080

cttttttggc actccctctg accccgcgat gagtgttttg gtggcagagg tgggatgagc   1140

tggaaaggta tggaggtggg agaggatggg gctcttctgt ctgtcctgct tcttcaggtg   1200

agtgcaggcc aaggcggggg tgagatggct gagcttccag cgccttctgt cctgcctgcc   1260

cagtcccttc actgctttcc tgccccaaga tggcttgctt ttcacaaata aagagaaaga   1320

gcagctttag ccttcttggt ggaatcccag gcagtgggag cagaatcaga actgccaggg   1380

aagggaaggg ggacctgggt ctcaatgggt ctcatttgag tctcgcgggc tgtgcagatg   1440

ccctgacaga gtcggtttcc tttggcggca ttccctttcc ctcattcagc acttctgctg   1500

ggaactccct gactattccg ctgctgcagg aacccagcta gctggccagg tggggagggg   1560

ctggggaccg gccaggaagg aggggtgact tcatcccaga gagacccgag ttcccccagc   1620

ccttcatcac caacccgctc ctgcaggagt gagtcttacc tcccctggcc ctcctttctg   1680

gctcagcctg cagcgactgt gaggccacag ctcctcagat tcactgcccg ctgtgtgcca   1740

gtactcaggc agctggagag aagagaaggc agcagcagag gcccccgccc tcaccccagc   1800

catctgcact tgtaccattt gctctgtgct gactgtggtc ctataaattc atgagaaata   1860

aactggttct gtgtgcaaaa aaaaa                                         1885


<210>  960
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  960

Met Glu Arg Pro Glu Pro Glu Leu Ile Arg Gln Ser Trp Arg Ala Val 
1               5                   10                  15


Ser Arg Ser Pro Leu Glu His Gly Thr Val Leu Phe Ala Arg Leu Phe 
            20                  25                  30


Ala Leu Glu Pro Asp Leu Leu Pro Leu Phe Gln Tyr Asn Cys Arg Gln 
        35                  40                  45


Phe Ser Ser Pro Glu Asp Cys Leu Ser Ser Pro Glu Phe Leu Asp His 
    50                  55                  60


Ile Arg Lys Val Met Leu Val Ile Asp Ala Ala Val Thr Asn Val Glu 
65                  70                  75                  80


Asp Leu Ser Ser Leu Glu Glu Tyr Leu Ala Ser Leu Gly Arg Lys His 
                85                  90                  95


Arg Ala Val Gly Val Lys Leu Ser Ser Phe Ser Thr Val Gly Glu Ser 
            100                 105                 110


Leu Leu Tyr Met Leu Glu Lys Cys Leu Gly Pro Ala Phe Thr Pro Ala 
        115                 120                 125


Thr Arg Ala Ala Trp Ser Gln Leu Tyr Gly Ala Val Val Gln Ala Met 
    130                 135                 140


Ser Arg Gly Trp Asp Gly Glu 
145                 150


<210>  961
<211>  4881
<212>  DNA
<213>  Homo sapiens

<400>  961
gccgcctcct agcggcccgg gccgcgacca cgctgcccgc cccgccccga gcccggggcc     60

ccgcgctccg ctgcagtgaa gggcgttgca tttcccgggg taccccgagc tgccctcttg    120

tgactccttg gcggggcggc tggtcagaca aagtgtgcct ccgggccgga gggcgaccca    180

gaggaggggg aagatgccgc cggccacggg cggaggcctg gcagagtccg agctgcgtcc    240

ccggaggggc cgctgtggcc cccaggctgc tagggccgca ggccgggacg tggccgctga    300

ggctgtggcg cgaagcccca aacggcctgc ttggggctca cggcgcttcg aggcggtcgg    360

ctggtgggcc ctgctggcct tggtgacgct gctgtccttc gccacccgct tccaccgctt    420

ggacgagccg ccgcacatct gttgggatga gactcacttt ggaaaaatgg gaagttacta    480

tatcaaccgt acatttttct ttgatgtgca cccgcccctg ggaaagatgc tgataggtct    540

tgctggctac ctgagtggat atgatggtac ctttttgttc cagaagcctg gggataaata    600

tgagcatcac agctacatgg gaatgagagg attctgtgca ttccttggct cctggctggt    660

cccctttgcc tacctcactg tactggatct gtccaagtcc ctctcggcag cactgctcac    720

agctgccctc ctcacctttg acacgggatg cctcactctg tcccagtaca tcctccttga    780

ccccatcctg atgttcttca tcatggctgc catgctgagc atggtcaagt acaactcttg    840

cgccgacagg cccttctctg ccccctggtg gttctggctc agcctgactg gcgttagtct    900

tgctggtgct ttaggggtca agtttgttgg cctctttatc atccttcaag tggggctgaa    960

caccattgca gacctttggt acctgttcgg agacctcagt ctttcattgg tgactgtggg   1020

aaaacacctg actgctcgtg tcctgtgcct catagtgctg cccctggctc tctatacagc   1080

cacctttgct gttcacttca tggtgctgag taaaagtggc cctggtgacg gtttcttcag   1140

ttctgccttc caggcccggc tttcagggaa caacctgcac aatgcttcca tccctgaaca   1200

cctggcctac ggctctgtga tcactgtgaa gaacctccgg atggccatcg gctatctgca   1260

ctcccacagg cacctctacc ccgagggcat tggtgcccgt cagcagcagg tcaccaccta   1320

tttgcacaag gactacaaca acctgtggat tatcaagaaa cataacacaa actcagatcc   1380

cctagaccct tccttcccag tggagtttgt aagacatgga gacattattc gactagaaca   1440

caaagaaact tcccggaact tgcacagtca ctatcatgag gcccccatga cccggaagca   1500

ctatcaggtc accggctatg gcataaatgg aacaggggac tcaaatgatt tctggcggat   1560

tgaggtcgta aacaggaaat ttggaaaccg gatcaaagtg ctgagaagtc gaattcgctt   1620

catccatttg gtcacaggtt gtgtcctggg ctcctcggga aaggttctgc ccaagtgggg   1680

ctgggagcag ttggaagtta cttgcacccc atacctgaaa gaaaccctca actccatctg   1740

gaatgtggag gaccatatca atcccaagtt gccaaacatc agcctggatg tgctacagcc   1800

cagttttcct gagatcttgc tggaatccca catggtcatg atccggggga acagtggcct   1860

caaacccaag gacaatgagt tcacgtccaa accctggcac tggcctatca actatcaggg   1920

cctacgcttc tcaggggtca atgacacaga tttccgagtc tatctgcttg gcaacccggt   1980

ggtttggtgg ctgaatctgt tgagcatcgc cctctacctc ctctcaggga gcatcattgc   2040

tgtagccatg cagagagggg cacggctgcc agcggaggtt gcagggttgt cccaggtcct   2100

gcttcgagga ggcggccagg tcctgctcgg ctggacactc cattacttcc cgtttttcct   2160

gatgggccgg gtcctctact tccaccacta cttcccagcc atgctcttct caagcatgtt   2220

gacaggcatt ctgtgggaca ccctcctgcg gctctgtgcc tggggcttgg cctcatggcc   2280

cctggcgagg ggcatacatg tggcgggaat cctgagcctg ctcctgggaa ctgcctacag   2340

cttctacctc ttccaccctc tggcttacgg gatggttggt cccctggccc aggaccccca   2400

aagtccaatg gcaggactaa ggtggctgga ctcatgggac ttttgaggcc actgcaaaga   2460

ttccagcctg ggtccaggaa cttcccagga gagccagctg ggaagcagta ctggaccatc   2520

cggccatgag gaagctgcct aaggagcccg aagaattctg ctgctcacca ggacccagct   2580

ctgggagtgc agctggaatg gaacccagca ttggagagag ccgggagaga gccgcagctc   2640

cgtccacagc accacggaga ggacagcgcc tcttgggctg ctccctcgtg cacagcgcag   2700

gggaggatgg gtgccagagg gtgggagtgg gtgcgcgtgt gtgtatgtga gggcatgttg   2760

tccatatccc tgtggaatac agaccgtgta actggacagc tgagtgtcat aaactctaaa   2820

atagtccagg ctatagtaat attttctggt atttttttct gttggatttc tttggttttg   2880

gtttgtaaga tccatcaaaa attctcagac ctctgagagg gccttgaggg cagagaatac   2940

tgacctcacc ttgggatgtc accaaaggca gagcagatgg gactgtcaaa gttgtgctgc   3000

cctccctccc acaaacaaat gaatccagcg tggaggaagg cgcgccgccc cgagctggag   3060

ggcctggctc ccaccatgcc ccccagtggc tgcaggtagc tggacttcct gcctgtgacg   3120

cacagagagc agcggactcc ggagcgtcag cctgccttag cccttggttc ctcgtttttt   3180

gggattgtca cactgtgaca ctcgggagga acgatgtcct atcctgggct gctcagtgtt   3240

cccaggccct gtgtgccaga ggccaggtct ctccaagtgc atctagcctg gcctggaggg   3300

caaggcagat gcattctcct ggctgctggg agagcccatg ggaaccttgc ttagcgccca   3360

aggtagatga gagacagggc agggaatctg cgtggtgctg ggatgtgggg actctggcct   3420

ctccagacta atgttcctgt cacctgctga gctttcccag tgtcacttct gcagtcctcc   3480

tctgctcacc cctccctcac tccgtgggca attccctttc tctctgtcac tgcttcagca   3540

gtgaagaccc atggcaccta gaaatgcatg ccagcttcct gcgtctacca ctctgcagct   3600

caaacaagaa gctcagagct gccccttcca cttcctcccc aaaagggatg aagaaaaccc   3660

tgtggtagaa ccaaaccacc caaggccagc ccttaagcct gcctccacct tcctggtgca   3720

tgacaaaata tttcttttgt ctcagaggac tttgatgctt caatatttaa tgatgaatcc   3780

gccacactcc attttccctc ctctgaagct cccaacaact ctgacagggt cagatctctt   3840

taaagcatct tcaggaggcg gttgccacgg agactggata ttggtcccag ggacaggctg   3900

tgctacctac tgggtggtgg ggagggaagc ttctggccat gcttgggcat tcagaccaac   3960

catcattaat gttaatagag gaaatgcagc aacgtcaaaa gcaaggcagg ttggttaatt   4020

agatctgggg cccgatgacc tccctttccc actgctacag cccttttgac ttcccccagc   4080

aggaagcgct gtctgtgcgg ctgagtctgg gccacttgct taattgcatt tctggcaggg   4140

aaggagagga gggatggaga agctctgctc gctgcttcca cctcaccgtg tgtcctcccc   4200

tcccctccct tcctctcctc cccacaggcg gaattgcttt cttctgagcc gggtgggctc   4260

tcctgcaggg agaatgcagg ggtctgtgct tggctcttag caaagcaggt ggcccacagt   4320

gacctccagg aggtggctga ttttcctttg tgccttctta tttctcagta ggaacttgga   4380

agggaagagc tctgaaggag ccagaggggc agccaccttg catgagggtg aggaaggaga   4440

agcccagcca gcctctaccc atccctccct cccaattagg ctgcactggg gccgaacgct   4500

tccctgggct cccactgcct tctaaggagc caaggagaat tccctgccca ctttctgttc   4560

ctccatgccc aaactggcag atgcttctct gggagcaagg ccacatgggc tgatgcagct   4620

ttgagtgctc aggttctgtt ttctggaagt tgctggagaa gggctgtcag ggtgcttcta   4680

tgaatatggg cttcagctgt agcacttggc agaaacgtga tgtgtcccac aaactgctgg   4740

tggaggaaga agatgttcgt cagccaattc aacctccagc cagcttcttg agcctatttg   4800

gtttaaaaaa aaaaagtctt ctaatcagaa gccactgatt ttataataaa taacacttgt   4860

tttgaaaaaa aaaaaaaaaa a                                             4881


<210>  962
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  962

Met Pro Pro Ala Thr Gly Gly Gly Leu Ala Glu Ser Glu Leu Arg Pro 
1               5                   10                  15


Arg Arg Gly Arg Cys Gly Pro Gln Ala Ala Arg Ala Ala Gly Arg Asp 
            20                  25                  30


Val Ala Ala Glu Ala Val Ala Arg Ser Pro Lys Arg Pro Ala Trp Gly 
        35                  40                  45


Ser Arg Arg Phe Glu Ala Val Gly Trp Trp Ala Leu Leu Ala Leu Val 
    50                  55                  60


Thr Leu Leu Ser Phe Ala Thr Arg Phe His Arg Leu Asp Glu Pro Pro 
65                  70                  75                  80


His Ile Cys Trp Asp Glu Thr His Phe Gly Lys Met Gly Ser Tyr Tyr 
                85                  90                  95


Ile Asn Arg Thr Phe Phe Phe Asp Val His Pro Pro Leu Gly Lys Met 
            100                 105                 110


Leu Ile Gly Leu Ala Gly Tyr Leu Ser Gly Tyr Asp Gly Thr Phe Leu 
        115                 120                 125


Phe Gln Lys Pro Gly Asp Lys Tyr Glu His His Ser Tyr Met Gly Met 
    130                 135                 140


Arg Gly Phe Cys Ala Phe Leu Gly Ser Trp Leu Val Pro Phe Ala Tyr 
145                 150                 155                 160


Leu Thr Val Leu Asp Leu Ser Lys Ser Leu Ser Ala Ala Leu Leu Thr 
                165                 170                 175


Ala Ala Leu Leu Thr Phe Asp Thr Gly Cys Leu Thr Leu Ser Gln Tyr 
            180                 185                 190


Ile Leu Leu Asp Pro Ile Leu Met Phe Phe Ile Met Ala Ala Met Leu 
        195                 200                 205


Ser Met Val Lys Tyr Asn Ser Cys Ala Asp Arg Pro Phe Ser Ala Pro 
    210                 215                 220


Trp Trp Phe Trp Leu Ser Leu Thr Gly Val Ser Leu Ala Gly Ala Leu 
225                 230                 235                 240


Gly Val Lys Phe Val Gly Leu Phe Ile Ile Leu Gln Val Gly Leu Asn 
                245                 250                 255


Thr Ile Ala Asp Leu Trp Tyr Leu Phe Gly Asp Leu Ser Leu Ser Leu 
            260                 265                 270


Val Thr Val Gly Lys His Leu Thr Ala Arg Val Leu Cys Leu Ile Val 
        275                 280                 285


Leu Pro Leu Ala Leu Tyr Thr Ala Thr Phe Ala Val His Phe Met Val 
    290                 295                 300


Leu Ser Lys Ser Gly Pro Gly Asp Gly Phe Phe Ser Ser Ala Phe Gln 
305                 310                 315                 320


Ala Arg Leu Ser Gly Asn Asn Leu His Asn Ala Ser Ile Pro Glu His 
                325                 330                 335


Leu Ala Tyr Gly Ser Val Ile Thr Val Lys Asn Leu Arg Met Ala Ile 
            340                 345                 350


Gly Tyr Leu His Ser His Arg His Leu Tyr Pro Glu Gly Ile Gly Ala 
        355                 360                 365


Arg Gln Gln Gln Val Thr Thr Tyr Leu His Lys Asp Tyr Asn Asn Leu 
    370                 375                 380


Trp Ile Ile Lys Lys His Asn Thr Asn Ser Asp Pro Leu Asp Pro Ser 
385                 390                 395                 400


Phe Pro Val Glu Phe Val Arg His Gly Asp Ile Ile Arg Leu Glu His 
                405                 410                 415


Lys Glu Thr Ser Arg Asn Leu His Ser His Tyr His Glu Ala Pro Met 
            420                 425                 430


Thr Arg Lys His Tyr Gln Val Thr Gly Tyr Gly Ile Asn Gly Thr Gly 
        435                 440                 445


Asp Ser Asn Asp Phe Trp Arg Ile Glu Val Val Asn Arg Lys Phe Gly 
    450                 455                 460


Asn Arg Ile Lys Val Leu Arg Ser Arg Ile Arg Phe Ile His Leu Val 
465                 470                 475                 480


Thr Gly Cys Val Leu Gly Ser Ser Gly Lys Val Leu Pro Lys Trp Gly 
                485                 490                 495


Trp Glu Gln Leu Glu Val Thr Cys Thr Pro Tyr Leu Lys Glu Thr Leu 
            500                 505                 510


Asn Ser Ile Trp Asn Val Glu Asp His Ile Asn Pro Lys Leu Pro Asn 
        515                 520                 525


Ile Ser Leu Asp Val Leu Gln Pro Ser Phe Pro Glu Ile Leu Leu Glu 
    530                 535                 540


Ser His Met Val Met Ile Arg Gly Asn Ser Gly Leu Lys Pro Lys Asp 
545                 550                 555                 560


Asn Glu Phe Thr Ser Lys Pro Trp His Trp Pro Ile Asn Tyr Gln Gly 
                565                 570                 575


Leu Arg Phe Ser Gly Val Asn Asp Thr Asp Phe Arg Val Tyr Leu Leu 
            580                 585                 590


Gly Asn Pro Val Val Trp Trp Leu Asn Leu Leu Ser Ile Ala Leu Tyr 
        595                 600                 605


Leu Leu Ser Gly Ser Ile Ile Ala Val Ala Met Gln Arg Gly Ala Arg 
    610                 615                 620


Leu Pro Ala Glu Val Ala Gly Leu Ser Gln Val Leu Leu Arg Gly Gly 
625                 630                 635                 640


Gly Gln Val Leu Leu Gly Trp Thr Leu His Tyr Phe Pro Phe Phe Leu 
                645                 650                 655


Met Gly Arg Val Leu Tyr Phe His His Tyr Phe Pro Ala Met Leu Phe 
            660                 665                 670


Ser Ser Met Leu Thr Gly Ile Leu Trp Asp Thr Leu Leu Arg Leu Cys 
        675                 680                 685


Ala Trp Gly Leu Ala Ser Trp Pro Leu Ala Arg Gly Ile His Val Ala 
    690                 695                 700


Gly Ile Leu Ser Leu Leu Leu Gly Thr Ala Tyr Ser Phe Tyr Leu Phe 
705                 710                 715                 720


His Pro Leu Ala Tyr Gly Met Val Gly Pro Leu Ala Gln Asp Pro Gln 
                725                 730                 735


Ser Pro Met Ala Gly Leu Arg Trp Leu Asp Ser Trp Asp Phe 
            740                 745                 750


<210>  963
<211>  1448
<212>  DNA
<213>  Homo sapiens

<400>  963
ccgggagggt tgggccagag gaggcggtcc tggtagggag tgcgtagcag ggtggagtcg     60

ctgtccggtc gcgcttcact tctgctccgc cctccctgct ccccataaca gacccctccc    120

tccactaagg cttccaaacg tcgccccaag cctcccaatt tctcgcagcc cttcatgctc    180

ttctcttggc cctagcagga gtggtcacca gcagtccctg tcccttggca ccaggagtcc    240

ctgtagcctg gctaggtaag gaaagggagt tgcatctcca aataaggaag atccagttgt    300

ggccacccaa ttcctcctct tcgaaagaca ctttctgccc atcacctgct ttctgtgcca    360

ggaccatctt tactttctcc acaaaagccc atcctctatt cctatttccg aagctcctgc    420

tcatggagag ttcgaattgc tctggccttg aaaggcatcg actacgagac ggtgcccatc    480

aatctcataa aggatggggg ccaacagttt tctaaggact tccaggcact gaatcctatg    540

aagcaggtgc caaccctgaa gattgatgga atcaccattc accagtcact ggccatcatt    600

gagtatctag aggagatgcg tcccactccg cgacttctgc ctcaggaccc aaagaagagg    660

gccagcgtgc gtatgatttc tgacctcatc gctggtggca tccagcccct gcagaacctg    720

tctgtcctga agcaagtggg agaggagatg cagctgacct gggcccagaa cgccatcact    780

tgtggcttta acgccctgga gcagatccta cagagcacag cgggcatata ctgtgtagga    840

gacgaggtga ccatggctga tctgtgcttg gtgcctcagg tggcaaatgc tgaaagattc    900

aaggtggatc tcacccccta ccctaccatc agctccatca acaagaggct gctggtcttg    960

gaggccttcc aggtgtctca cccctgccgg cagccagata cacccactga gctgagggcc   1020

tagctcccaa atcctgcccc gttggcacag ggccacagga gcagaagctg ggtgggctga   1080

agaggcctgg aaacgagagt cttaattgag gagatgggag actcgaactc tagccctgga   1140

tctgccttcc tgctgaaact tgttccacct cagtcccctc atctgtcaca cgcatgtggg   1200

gtggagtagg gagatgcggg gagcagggtg ggcaggaata ctgttatcta tgtgacgggg   1260

cagtcgtgag gctgagatga gaatgcggat taaaatgcct ggcgtgctca ccgtaacacc   1320

acggggaagg ctgtgtgcct tttctcatcc gcttttgttg tgtgtgactc caaagaatgc   1380

ccgcgctgaa atttggcgtg aattaaactg aagcccaggc ctctaaaaaa aaaaaaaaaa   1440

aaaaaaaa                                                            1448


<210>  964
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  964

Met Lys Gln Val Pro Thr Leu Lys Ile Asp Gly Ile Thr Ile His Gln 
1               5                   10                  15


Ser Leu Ala Ile Ile Glu Tyr Leu Glu Glu Met Arg Pro Thr Pro Arg 
            20                  25                  30


Leu Leu Pro Gln Asp Pro Lys Lys Arg Ala Ser Val Arg Met Ile Ser 
        35                  40                  45


Asp Leu Ile Ala Gly Gly Ile Gln Pro Leu Gln Asn Leu Ser Val Leu 
    50                  55                  60


Lys Gln Val Gly Glu Glu Met Gln Leu Thr Trp Ala Gln Asn Ala Ile 
65                  70                  75                  80


Thr Cys Gly Phe Asn Ala Leu Glu Gln Ile Leu Gln Ser Thr Ala Gly 
                85                  90                  95


Ile Tyr Cys Val Gly Asp Glu Val Thr Met Ala Asp Leu Cys Leu Val 
            100                 105                 110


Pro Gln Val Ala Asn Ala Glu Arg Phe Lys Val Asp Leu Thr Pro Tyr 
        115                 120                 125


Pro Thr Ile Ser Ser Ile Asn Lys Arg Leu Leu Val Leu Glu Ala Phe 
    130                 135                 140


Gln Val Ser His Pro Cys Arg Gln Pro Asp Thr Pro Thr Glu Leu Arg 
145                 150                 155                 160


Ala 



<210>  965
<211>  1231
<212>  DNA
<213>  Homo sapiens

<400>  965
gccagaggcg accggaagga tctttctagt ccagcccctc gctttacccg gacgaaagac     60

acgggcctga ttcgtcgagt ctcactgagc cttagtcgtc ggcaggtccc aggcgcgaag    120

tttctcggcc tggaggaggg ggtcgcgcga agtgccagat gcaggcgggg aagcccatcc    180

tctattccta tttccgaagc tcctgctcat ggagagttcg aattgctctg gccttgaaag    240

gcatcgacta cgagacggtg cccatcaatc tcataaagga tgggggccaa cagttttcta    300

aggacttcca ggcactgaat cctatgaagc aggtgccaac cctgaagatt gatggaatca    360

ccattcacca gtcactggcc atcattgagt atctagagga gatgcgtccc actccgcgac    420

ttctgcctca ggacccaaag aagagggcca gcgtgcgtat gatttctgac ctcatcgctg    480

gtggcatcca gcccctgcag aacctgtctg tcctgaagca agtgggagag gagatgcagc    540

tgacctgggc ccagaacgcc atcacttgtg gctttaacgc cctggagcag atcctacaga    600

gcacagcggg catatactgt gtaggagacg aggtgaccat ggctgatctg tgcttggtgc    660

ctcaggtggc aaatgctgaa agattcaagg tggatctcac cccctaccct accatcagct    720

ccatcaacaa gaggctgctg gtcttggagg ccttccaggt gtctcacccc tgccggcagc    780

cagatacacc cactgagctg agggcctagc tcccaaatcc tgccccgttg gcacagggcc    840

acaggagcag aagctgggtg ggctgaagag gcctggaaac gagagtctta attgaggaga    900

tgggagactc gaactctagc cctggatctg ccttcctgct gaaacttgtt ccacctcagt    960

cccctcatct gtcacacgca tgtggggtgg agtagggaga tgcggggagc agggtgggca   1020

ggaatactgt tatctatgtg acggggcagt cgtgaggctg agatgagaat gcggattaaa   1080

atgcctggcg tgctcaccgt aacaccacgg ggaaggctgt gtgccttttc tcatccgctt   1140

ttgttgtgtg tgactccaaa gaatgcccgc gctgaaattt ggcgtgaatt aaactgaagc   1200

ccaggcctct aaaaaaaaaa aaaaaaaaaa a                                  1231


<210>  966
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  966

Met Gln Ala Gly Lys Pro Ile Leu Tyr Ser Tyr Phe Arg Ser Ser Cys 
1               5                   10                  15


Ser Trp Arg Val Arg Ile Ala Leu Ala Leu Lys Gly Ile Asp Tyr Glu 
            20                  25                  30


Thr Val Pro Ile Asn Leu Ile Lys Asp Gly Gly Gln Gln Phe Ser Lys 
        35                  40                  45


Asp Phe Gln Ala Leu Asn Pro Met Lys Gln Val Pro Thr Leu Lys Ile 
    50                  55                  60


Asp Gly Ile Thr Ile His Gln Ser Leu Ala Ile Ile Glu Tyr Leu Glu 
65                  70                  75                  80


Glu Met Arg Pro Thr Pro Arg Leu Leu Pro Gln Asp Pro Lys Lys Arg 
                85                  90                  95


Ala Ser Val Arg Met Ile Ser Asp Leu Ile Ala Gly Gly Ile Gln Pro 
            100                 105                 110


Leu Gln Asn Leu Ser Val Leu Lys Gln Val Gly Glu Glu Met Gln Leu 
        115                 120                 125


Thr Trp Ala Gln Asn Ala Ile Thr Cys Gly Phe Asn Ala Leu Glu Gln 
    130                 135                 140


Ile Leu Gln Ser Thr Ala Gly Ile Tyr Cys Val Gly Asp Glu Val Thr 
145                 150                 155                 160


Met Ala Asp Leu Cys Leu Val Pro Gln Val Ala Asn Ala Glu Arg Phe 
                165                 170                 175


Lys Val Asp Leu Thr Pro Tyr Pro Thr Ile Ser Ser Ile Asn Lys Arg 
            180                 185                 190


Leu Leu Val Leu Glu Ala Phe Gln Val Ser His Pro Cys Arg Gln Pro 
        195                 200                 205


Asp Thr Pro Thr Glu Leu Arg Ala 
    210                 215


<210>  967
<211>  1145
<212>  DNA
<213>  Homo sapiens

<400>  967
gccagaggcg accggaagga tctttctagt ccagcccctc gctttacccg gacgaaagac     60

acgggcctga ttcgtcgagt ctcactgagc cttagtcgtc ggcaggtccc aggcgcgaag    120

tttctcggcc tggaggaggg ggtcgcgcga agtgccagat gcaggcgggg aagcccatcc    180

tctattccta tttccgaagc tcctgctcat ggagagttcg aattgctctg gccttgaaag    240

gcatcgacta caagacggtg cccatcaatc tcataaagga tgggggccaa cagttttcta    300

aggacttcca ggcactgaat cctatgaagc aggtgccaac cctgaagatt gatggaatca    360

ccattcacca gtcaaacctg tctgtcctga agcaagtggg agaggagatg cagctgacct    420

gggcccagaa cgccatcact tgtggcttta acgccctgga gcagatccta cagagcacag    480

cgggcatata ctgtgtagga gacgaggtga ccatggctga tctgtgcttg gtgcctcagg    540

tggcaaatgc tgaaagattc aaggtggatc tcacccccta ccctaccatc agctccatca    600

acaagaggct gctggtcttg gaggccttcc aggtgtctca cccctgccgg cagccagata    660

cacccactga gctgagggcc tagctcccaa atcctgcccc gttggcacag ggccacagga    720

gcagaagctg ggtgggctga agaggcctgg aaacgagagt cttaattgag gagatgggag    780

actcgaactc tagccctgga tctgccttcc tgctgaaact tgttccacct cagtcccctc    840

atctgtcaca cgcatgtggg gtggagtagg gagatgcggg gagcagggtg ggcaggaata    900

ctgttatcta tgtgacgggg cagtcgtgag gctgagatga gaatgcggat taaaatgcct    960

ggcgtgctca ccgtaacacc acggggaagg ctgtgtgcct tttctcatcc gcttttgttg   1020

tgtgtgactc caaagaatgc ccgcgctgaa atttggcgtg aattaaactg aagcccaggc   1080

ctctaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1140

aaaaa                                                               1145


<210>  968
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  968

Met Gln Ala Gly Lys Pro Ile Leu Tyr Ser Tyr Phe Arg Ser Ser Cys 
1               5                   10                  15


Ser Trp Arg Val Arg Ile Ala Leu Ala Leu Lys Gly Ile Asp Tyr Lys 
            20                  25                  30


Thr Val Pro Ile Asn Leu Ile Lys Asp Gly Gly Gln Gln Phe Ser Lys 
        35                  40                  45


Asp Phe Gln Ala Leu Asn Pro Met Lys Gln Val Pro Thr Leu Lys Ile 
    50                  55                  60


Asp Gly Ile Thr Ile His Gln Ser Asn Leu Ser Val Leu Lys Gln Val 
65                  70                  75                  80


Gly Glu Glu Met Gln Leu Thr Trp Ala Gln Asn Ala Ile Thr Cys Gly 
                85                  90                  95


Phe Asn Ala Leu Glu Gln Ile Leu Gln Ser Thr Ala Gly Ile Tyr Cys 
            100                 105                 110


Val Gly Asp Glu Val Thr Met Ala Asp Leu Cys Leu Val Pro Gln Val 
        115                 120                 125


Ala Asn Ala Glu Arg Phe Lys Val Asp Leu Thr Pro Tyr Pro Thr Ile 
    130                 135                 140


Ser Ser Ile Asn Lys Arg Leu Leu Val Leu Glu Ala Phe Gln Val Ser 
145                 150                 155                 160


His Pro Cys Arg Gln Pro Asp Thr Pro Thr Glu Leu Arg Ala 
                165                 170


<210>  969
<211>  7185
<212>  DNA
<213>  Homo sapiens

<400>  969
agttgtacgt tcgaaacctg tcgccgtcac ttgcgcgttt ggcattatcc attgtcaccg     60

cggaggaacg agcgctcgag atatcatcag tgcccgcaaa tctccgcgcc aaggcgctga    120

gctactcctt tccgaggtgc gcctctggtc ctccgtccct ggtgcccagc agcggcgagg    180

cggcatctcc gctcccgccg ccgtgtccac cgagccctgg gatcagggtg gcagttctca    240

acgatgggca ggagggacct cggcggcgac ccctaaaaca ataccatgcc ccgggatccc    300

cgctgctgcc gcgccagcgt cttccctttc cacctccctg accctgtcgg attcggatga    360

gcccattgca aggagaagac gcagccgtca gattgcagat tgagcttaac caagaagttc    420

gtaggctaat caaggctggc ttgacctaca aaagaagaag agagttctgc ctgcccactt    480

gggcttgtgt tgacacggct gataacttgc catcacctgt tgccagtgtg gaaaaattct    540

ccctgttgaa ttttttgcac atggaggaca gcagcaaaga gggcaacaca ggctgataag    600

accagagaca gcagggagat tattttacca tacgccctca ggacgttccc tctagctgga    660

gttctggact tcaacagaac cccatccagt cattttgatt ttgctgttta tttttttttt    720

ctttttcttt ttcccaccac attgtatttt atttccgtac ttcagaaatg ggcctacaga    780

ccacaaagtg gcccagccat ggggcttttt tcctgaagtc ttggcttatc atttccctgg    840

ggctctactc acaggtgtcc aaactcctgg cctgccctag tgtgtgccgc tgcgacagga    900

actttgtcta ctgtaatgag cgaagcttga cctcagtgcc tcttgggatc ccggagggcg    960

taaccgtact ctacctccac aacaaccaaa ttaataatgc tggatttcct gcagaactgc   1020

acaatgtaca gtcggtgcac acggtctacc tgtatggcaa ccaactggac gaattcccca   1080

tgaaccttcc caagaatgtc agagttctcc atttgcagga aaacaatatt cagaccattt   1140

cacgggctgc tcttgcccag ctcttgaagc ttgaagagct gcacctggat gacaactcca   1200

tatccacagt gggggtggaa gacggggcct tccgggaggc tattagcctc aaattgttgt   1260

ttttgtctaa gaatcacctg agcagtgtgc ctgttgggct tcctgtggac ttgcaagagc   1320

tgagagtgga tgaaaatcga attgctgtca tatccgacat ggccttccag aatctcacga   1380

gcttggagcg tcttattgtg gacgggaacc tcctgaccaa caagggtatc gccgagggca   1440

ccttcagcca tctcaccaag ctcaaggaat tttcaattgt acgtaattcg ctgtcccacc   1500

ctcctcccga tctcccaggt acgcatctga tcaggctcta tttgcaggac aaccagataa   1560

accacattcc tttgacagcc ttctcaaatc tgcgtaagct ggaacggctg gatatatcca   1620

acaaccaact gcggatgctg actcaagggg tttttgataa tctctccaac ctgaagcagc   1680

tcactgctcg gaataaccct tggttttgtg actgcagtat taaatgggtc acagaatggc   1740

tcaaatatat cccttcatct ctcaacgtgc ggggtttcat gtgccaaggt cctgaacaag   1800

tccgggggat ggccgtcagg gaattaaata tgaatctttt gtcctgtccc accacgaccc   1860

ccggcctgcc tctcttcacc ccagccccaa gtacagcttc tccgaccact cagcctccca   1920

ccctctctat tccaaaccct agcagaagct acacgcctcc aactcctacc acatcgaaac   1980

ttcccacgat tcctgactgg gatggcagag aaagagtgac cccacctatt tctgaacgga   2040

tccagctctc tatccatttt gtgaatgata cttccattca agtcagctgg ctctctctct   2100

tcaccgtgat ggcatacaaa ctcacatggg tgaaaatggg ccacagttta gtagggggca   2160

tcgttcagga gcgcatagtc agcggtgaga agcaacacct gagcctggtt aacttagagc   2220

cccgatccac ctatcggatt tgtttagtgc cactggatgc ttttaactac cgcgcggtag   2280

aagacaccat ttgttcagag gccaccaccc atgcctccta tctgaacaac ggcagcaaca   2340

cagcgtccag ccatgagcag acgacgtccc acagcatggg ctcccccttt ctgctggcgg   2400

gcttgatcgg gggcgcggtg atatttgtgc tggtggtctt gctcagcgtc ttttgctggc   2460

atatgcacaa aaaggggcgc tacacctccc agaagtggaa atacaaccgg ggccggcgga   2520

aagatgatta ttgcgaggca ggcaccaaga aggacaactc catcctggag atgacagaaa   2580

ccagttttca gatcgtctcc ttaaataacg atcaactcct taaaggagat ttcagactgc   2640

agcccattta caccccaaat gggggcatta attacacaga ctgccatatc cccaacaaca   2700

tgcgatactg caacagcagc gtgccagacc tggagcactg ccatacgtga cagccagagg   2760

cccagcgtta tcaaggcgga caattagact cttgagaaca cactcgtgtg tgcacataaa   2820

gacacgcaga ttacatttga taaatgttac acagatgcat ttgtgcattt gaatactctg   2880

taatttatac ggtgtactat ataatgggat ttaaaaaaag tgctatcttt tctatttcaa   2940

gttaattaca aacagttttg taactctttg ctttttaaat cttaaaaaaa aaaaagttgc   3000

tgaagtactg tacagggttg tacaatgaga acccaatgcc aaggcaaaaa gaacgagtga   3060

tttttcctta ggatacacat caaccacttt gctgttgaag ctgtcagaat aaattcctgg   3120

tggtcagatg aaagggcaga ttaaatggac tcatcagggt aagaggaata atatgggtaa   3180

aacaagaaat ggcccgatag tttcacacta ttcctatacc tccaggtccg gaagacaggt   3240

aaaaaattct ataatgtaag aatggaggta gttaccctga tttgaccctg tgtgggaaat   3300

gctgaaagca ccaggaggaa gccggttccc gtgagataag ttaacccggc ctgacagaat   3360

caagaaaatt gagatgagat ttgaaaggac ccgaaaatgc aggggttggc tttctgactg   3420

ggaacttaaa aatcactctt catgcttccc tggtcctatg tgataacaga gttagagact   3480

tgagtctgat ttcagtcatc ttcagggacc agtctgatgt tgtagcaaga agactccctt   3540

taaaagtgtt actgttcaaa tcatatatca ggttgaatca cattcaacag agatatattc   3600

tagaatactt ttttagaaga ggctaataaa gggaagaatt atattgaatg gaattatttt   3660

tgataatgag aattatttgg gtagattcac tgaggctatg tcaacatgat atttagacca   3720

acaggtgatc aatgtttgga aaatacaaca atgacttatt taaaaattac ccttcctgct   3780

atttagacaa aaacaactga tcagtggttc tgttatgtca gctgactttg ttagtatcat   3840

gttgaaatag cttgaagtaa tatcttttat ccccttgcaa attcttgtct tccaatcatc   3900

tcccatatat tttcataatt agttgtttat gacacctttg tttttctccc tctgttcagt   3960

atttcaagga aaattatgga tgccagtctt ggctgcacaa gatatccatt acgtacttat   4020

acattttaaa atgagtacta attttcactg ctaataattc tgtaaggaca catcaaagct   4080

ggccaaaata atgaattttt tttaaaaagc aatacctggt ttccaccttg gactgacttt   4140

gatcctgttc cacttttgaa attttatttg ttccttttcc atcgtggatg ttcctctact   4200

ttggcaattg tggagggcta atcaatctta tgttagcagg acaacccatg aaaaacaagt   4260

cagagagtga aggctttttc ccctaatcct ggcagagcag ggcgtagaaa agagaggatg   4320

tccgtgctta attctagata cttttgagac aacaccttca gaaaacacat aatttaatct   4380

ttgccatcct tagatagaga agggctatag atcacatacg ttatcaaaaa ctactccctt   4440

ggaaaaaata tctttcgaaa atcaaattta aacatttcac tctgtgctgc atatttcttt   4500

taccattgac cattattata gggacccatg aagtaaatgt cacaatcatc ttactagctc   4560

tctctctctc agcaaaataa aactgtgatg tgtcttcttt gtaaaagttt aggtataaaa   4620

tgctatgcaa ctttttcttt atagtaagag ctttattttc tttaataata tagcccaact   4680

tatatgtttt aatctccctt gtccctcaga ataagcagaa aatataactg cagctgtatg   4740

tcgtagacac aagaattgaa actgtgcagt cagtagagct gaacttagct atgaattaat   4800

ttaaattaat tctaaagtga ctctggtttc cattttagtc tattagctag agggttttgg   4860

ctgttgcttt ttttaaagtt aggtccacac agtgaaggga aaagagtctg tgaaggtgat   4920

cagtgtagca gtaagacatc taaaatcaag acaatgacat gggggctttg tgtacttagc   4980

tggataattc ccttctactg tcctcttccc cttggctgtg tagataaaat tgtgcattca   5040

aatgatggta ctttgacttt tgagggtttt tatttctgtt attcacaaaa tactcattct   5100

catttatgta tattgtatgt ttaaccccca gtgggatttc tggctgctga aaccactttg   5160

ggccaggaag aacaaggatg aagaggttcc tgtcatttct tatggggttc acagaattat   5220

ttggggctta aatggtacaa tggagacagt catgtgcaat gcttaagatg gtctgacagg   5280

gtcccttttg ctggaggtgt tcctgaagag attgaaccta gtaacaggct ttattttcac   5340

cttgtgtaca acatggcaaa gactgctaag attaaaatcc gtctcccatt tgttacagcc   5400

tcacctgcac caggatagaa agcacgtgat ggaatctgtg atgtctaatg tgtcttatga   5460

aaattgccaa acaactgtcc ctggggattc tgctttgatt ggcattttta gtcatgggaa   5520

tgtatatttg ctgatatatc tgctctgtgt ttgggcctct cttgctgtca ttatgatgta   5580

ttttgagatg attagtcaag agtcaaggtt gcgagtacag gccaagacca tgggaaaaaa   5640

agccatgctc actggccaat aaagagcttg atgctgcctg gccaaatgag gtgactcaga   5700

tagaatctga tcccattcag agcttggtaa atgtcactgt acagaagaca ttgaaaagga   5760

agaggcatag tcatgatcaa aaggatatat tgacagttat ctatagccag ggtagttgtt   5820

aatacctgct tgtttgggga gatatgtttg attatagaga gactctgggc caccctcaaa   5880

caccgtcaga tgcattagca gcccactgca tgggacaatc gcaggcagat acgaggaatg   5940

tatcccctgc ctattttcct tgtgtaacaa atggaaaaca ttctcccctg tgagaaataa   6000

tgcaatttct aattatctgg atgttcgttg aaaatatatt agacattctc cctgaggtta   6060

aaaacaaaaa gtacgtgacc agtctggtaa gaagtattaa tgaagtagct aatattacag   6120

cttcattttc tactagcacc tatcataatg gtcttagtca tttcacacaa atcagaactt   6180

ccttccccac cagggaggac aacatcttca tgctgtgatt gaagcatcca ttcagaacac   6240

gaggcaatat tgcagtccac agggaatgga tgcttcactt gatctccgga ccttggctgc   6300

agaggccatc gcagcttttg aaaagtgaag gggttaattc ccattggtgt ctttgcttat   6360

agcatttttc tctaacctat aacaaggaga cattacattt tactttagaa catgagaata   6420

gcagttttgc tcatgactta ccattccagc tgcatgggaa agcaaagcag aaaacagtgc   6480

cccaaatgga aaaaagatac tcacacagaa caaaacagtt cttggtcttg ttcttggtct   6540

tgtcaaacct tgcctgatgc tctttctaaa gtcaaaatat gaatgctaag aaggcataac   6600

ctacatcctt ctctgatttc ttcagcaggg tcaaaagaca gttactagca atggggaatg   6660

cttgtcactg tggagaaaga gttttgtata tgtctgatac cgttgttata acaaaacaaa   6720

tttttttact atagtttttt gttttctacc tgcacaccca ccagaagagc acaaagcaag   6780

gccattgcaa caggcattta aaaattatta tcaaacatgc acatgcttgt acacacacac   6840

acacacacac acaaacaggg gcatttgtaa aggtgtccct ggaatgtaag atttataatg   6900

tttaaggcaa ggtgaaggca ttgccaagtg tgtgtcgctc ataggactag tgtatattca   6960

ctgaaagtta acctgatgat ttgttattgt ttgaaccata tgctgatttg cttctggttt   7020

ctgtttagtg tgttctctct gataaggggc tgaaagattc tgcatcacac atcctctgag   7080

acctaccatg tcgcacactt tgttaatgac aaacttcact ctacactata cagtaccttg   7140

ttgatatatt cagtaaagtc ttattttaaa agaaaaccaa aaaaa                   7185


<210>  970
<211>  660
<212>  PRT
<213>  Homo sapiens

<400>  970

Met Gly Leu Gln Thr Thr Lys Trp Pro Ser His Gly Ala Phe Phe Leu 
1               5                   10                  15


Lys Ser Trp Leu Ile Ile Ser Leu Gly Leu Tyr Ser Gln Val Ser Lys 
            20                  25                  30


Leu Leu Ala Cys Pro Ser Val Cys Arg Cys Asp Arg Asn Phe Val Tyr 
        35                  40                  45


Cys Asn Glu Arg Ser Leu Thr Ser Val Pro Leu Gly Ile Pro Glu Gly 
    50                  55                  60


Val Thr Val Leu Tyr Leu His Asn Asn Gln Ile Asn Asn Ala Gly Phe 
65                  70                  75                  80


Pro Ala Glu Leu His Asn Val Gln Ser Val His Thr Val Tyr Leu Tyr 
                85                  90                  95


Gly Asn Gln Leu Asp Glu Phe Pro Met Asn Leu Pro Lys Asn Val Arg 
            100                 105                 110


Val Leu His Leu Gln Glu Asn Asn Ile Gln Thr Ile Ser Arg Ala Ala 
        115                 120                 125


Leu Ala Gln Leu Leu Lys Leu Glu Glu Leu His Leu Asp Asp Asn Ser 
    130                 135                 140


Ile Ser Thr Val Gly Val Glu Asp Gly Ala Phe Arg Glu Ala Ile Ser 
145                 150                 155                 160


Leu Lys Leu Leu Phe Leu Ser Lys Asn His Leu Ser Ser Val Pro Val 
                165                 170                 175


Gly Leu Pro Val Asp Leu Gln Glu Leu Arg Val Asp Glu Asn Arg Ile 
            180                 185                 190


Ala Val Ile Ser Asp Met Ala Phe Gln Asn Leu Thr Ser Leu Glu Arg 
        195                 200                 205


Leu Ile Val Asp Gly Asn Leu Leu Thr Asn Lys Gly Ile Ala Glu Gly 
    210                 215                 220


Thr Phe Ser His Leu Thr Lys Leu Lys Glu Phe Ser Ile Val Arg Asn 
225                 230                 235                 240


Ser Leu Ser His Pro Pro Pro Asp Leu Pro Gly Thr His Leu Ile Arg 
                245                 250                 255


Leu Tyr Leu Gln Asp Asn Gln Ile Asn His Ile Pro Leu Thr Ala Phe 
            260                 265                 270


Ser Asn Leu Arg Lys Leu Glu Arg Leu Asp Ile Ser Asn Asn Gln Leu 
        275                 280                 285


Arg Met Leu Thr Gln Gly Val Phe Asp Asn Leu Ser Asn Leu Lys Gln 
    290                 295                 300


Leu Thr Ala Arg Asn Asn Pro Trp Phe Cys Asp Cys Ser Ile Lys Trp 
305                 310                 315                 320


Val Thr Glu Trp Leu Lys Tyr Ile Pro Ser Ser Leu Asn Val Arg Gly 
                325                 330                 335


Phe Met Cys Gln Gly Pro Glu Gln Val Arg Gly Met Ala Val Arg Glu 
            340                 345                 350


Leu Asn Met Asn Leu Leu Ser Cys Pro Thr Thr Thr Pro Gly Leu Pro 
        355                 360                 365


Leu Phe Thr Pro Ala Pro Ser Thr Ala Ser Pro Thr Thr Gln Pro Pro 
    370                 375                 380


Thr Leu Ser Ile Pro Asn Pro Ser Arg Ser Tyr Thr Pro Pro Thr Pro 
385                 390                 395                 400


Thr Thr Ser Lys Leu Pro Thr Ile Pro Asp Trp Asp Gly Arg Glu Arg 
                405                 410                 415


Val Thr Pro Pro Ile Ser Glu Arg Ile Gln Leu Ser Ile His Phe Val 
            420                 425                 430


Asn Asp Thr Ser Ile Gln Val Ser Trp Leu Ser Leu Phe Thr Val Met 
        435                 440                 445


Ala Tyr Lys Leu Thr Trp Val Lys Met Gly His Ser Leu Val Gly Gly 
    450                 455                 460


Ile Val Gln Glu Arg Ile Val Ser Gly Glu Lys Gln His Leu Ser Leu 
465                 470                 475                 480


Val Asn Leu Glu Pro Arg Ser Thr Tyr Arg Ile Cys Leu Val Pro Leu 
                485                 490                 495


Asp Ala Phe Asn Tyr Arg Ala Val Glu Asp Thr Ile Cys Ser Glu Ala 
            500                 505                 510


Thr Thr His Ala Ser Tyr Leu Asn Asn Gly Ser Asn Thr Ala Ser Ser 
        515                 520                 525


His Glu Gln Thr Thr Ser His Ser Met Gly Ser Pro Phe Leu Leu Ala 
    530                 535                 540


Gly Leu Ile Gly Gly Ala Val Ile Phe Val Leu Val Val Leu Leu Ser 
545                 550                 555                 560


Val Phe Cys Trp His Met His Lys Lys Gly Arg Tyr Thr Ser Gln Lys 
                565                 570                 575


Trp Lys Tyr Asn Arg Gly Arg Arg Lys Asp Asp Tyr Cys Glu Ala Gly 
            580                 585                 590


Thr Lys Lys Asp Asn Ser Ile Leu Glu Met Thr Glu Thr Ser Phe Gln 
        595                 600                 605


Ile Val Ser Leu Asn Asn Asp Gln Leu Leu Lys Gly Asp Phe Arg Leu 
    610                 615                 620


Gln Pro Ile Tyr Thr Pro Asn Gly Gly Ile Asn Tyr Thr Asp Cys His 
625                 630                 635                 640


Ile Pro Asn Asn Met Arg Tyr Cys Asn Ser Ser Val Pro Asp Leu Glu 
                645                 650                 655


His Cys His Thr 
            660


<210>  971
<211>  1851
<212>  DNA
<213>  Homo sapiens

<400>  971
atcatttgca tgtctagctg gagaataaaa ataatatatc atttgcatgt cttagtaatg     60

aagtcatggg tgtcgtggca tgagatcagc tggagggaga ggagagatta aagtgaggag    120

agagctacaa ccaagtaagc aagtgtcagg gctcaccaac catgcaagga cagggcagga    180

gaagaggaac ctgcaaagac atattttgtt ccaaaatggc atcttacctt tatggagtac    240

tctttgctgt tggcctctgt gctccaatct actgtgtgtc cccggccaat gcccccagtg    300

catacccccg cccttcctcc acaaagagca cccctgcctc acaggtgtat tccctcaaca    360

ccgactttgc cttccgccta taccgcaggc tggttttgga gaccccgagt cagaacatct    420

tcttctcccc tgtgagtgtc tccacttccc tggccatgct ctcccttggg gcccactcag    480

tcaccaagac ccagattctc cagggcctgg gcttcaacct cacacacaca ccagagtctg    540

ccatccacca gggcttccag cacctggttc actcactgac tgttcccagc aaagacctga    600

ccttgaagat gggaagtgcc ctcttcgtca agaaggagct gcagctgcag gcaaatttct    660

tgggcaatgt caagaggctg tatgaagcag aagtcttttc tacagatttc tccaacccct    720

ccattgccca ggcgaggatc aacagccatg tgaaaaagaa gacccaaggg aaggttgtag    780

acataatcca aggccttgac cttctgacgg ccatggttct ggtgaaccac attttcttta    840

aagccaagtg ggagaagccc tttcaccctg aatatacaag aaagaacttc ccattcctgg    900

tgggcgagca ggtcactgtg catgtcccca tgatgcacca gaaagagcag ttcgcttttg    960

gggtggatac agagctgaac tgctttgtgc tgcagatgga ttacaaggga gatgccgtgg   1020

ccttctttgt cctccctagc aagggcaaga tgaggcaact ggaacaggcc ttgtcagcca   1080

gaacactgag aaagtggagc cactcactcc agaaaaggtg gatagaggtg ttcatcccca   1140

gattttccat ttctgcctcc tacaatctgg aaaccatcct cccgaagatg ggcatccaaa   1200

atgtctttga caaaaatgct gatttttctg gaattgcaaa gagagactcc ctgcaggttt   1260

ctaaagcaac ccacaaggct gtgctggatg tcagtgaaga gggcactgag gccacagcag   1320

ctaccaccac caagttcata gtccgatcga aggatggccc ctcttacttc actgtctcct   1380

tcaataggac cttcctgatg atgattacaa ataaagccac agacggtatt ctctttctag   1440

ggaaagtgga aaatcccact aaatcctagg tgggaaatgg cctgttaact gatggcacat   1500

tgctaatgca caagaaataa caaaccacat ccctctttct gttctgaggg tgcatttgac   1560

cccagtggag ctggattcgc tggcagggat gccacttcca aggctcaatc accaaaccat   1620

caacagggac cccagtcaca agccaacacc cattaacccc agtcagtgcc cttttccaca   1680

aattctccca ggtaactagc ttcatgggat gttgctgggt taccatattt ccattccttg   1740

gggctcccag gaatggaaat acgccaaccc aggttaggca cctctattgc agaattacaa   1800

taacacattc aataaaacta aaatatgaat tcatctgtca aaaaaaaaaa a            1851


<210>  972
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  972

Met Gln Gly Gln Gly Arg Arg Arg Gly Thr Cys Lys Asp Ile Phe Cys 
1               5                   10                  15


Ser Lys Met Ala Ser Tyr Leu Tyr Gly Val Leu Phe Ala Val Gly Leu 
            20                  25                  30


Cys Ala Pro Ile Tyr Cys Val Ser Pro Ala Asn Ala Pro Ser Ala Tyr 
        35                  40                  45


Pro Arg Pro Ser Ser Thr Lys Ser Thr Pro Ala Ser Gln Val Tyr Ser 
    50                  55                  60


Leu Asn Thr Asp Phe Ala Phe Arg Leu Tyr Arg Arg Leu Val Leu Glu 
65                  70                  75                  80


Thr Pro Ser Gln Asn Ile Phe Phe Ser Pro Val Ser Val Ser Thr Ser 
                85                  90                  95


Leu Ala Met Leu Ser Leu Gly Ala His Ser Val Thr Lys Thr Gln Ile 
            100                 105                 110


Leu Gln Gly Leu Gly Phe Asn Leu Thr His Thr Pro Glu Ser Ala Ile 
        115                 120                 125


His Gln Gly Phe Gln His Leu Val His Ser Leu Thr Val Pro Ser Lys 
    130                 135                 140


Asp Leu Thr Leu Lys Met Gly Ser Ala Leu Phe Val Lys Lys Glu Leu 
145                 150                 155                 160


Gln Leu Gln Ala Asn Phe Leu Gly Asn Val Lys Arg Leu Tyr Glu Ala 
                165                 170                 175


Glu Val Phe Ser Thr Asp Phe Ser Asn Pro Ser Ile Ala Gln Ala Arg 
            180                 185                 190


Ile Asn Ser His Val Lys Lys Lys Thr Gln Gly Lys Val Val Asp Ile 
        195                 200                 205


Ile Gln Gly Leu Asp Leu Leu Thr Ala Met Val Leu Val Asn His Ile 
    210                 215                 220


Phe Phe Lys Ala Lys Trp Glu Lys Pro Phe His Pro Glu Tyr Thr Arg 
225                 230                 235                 240


Lys Asn Phe Pro Phe Leu Val Gly Glu Gln Val Thr Val His Val Pro 
                245                 250                 255


Met Met His Gln Lys Glu Gln Phe Ala Phe Gly Val Asp Thr Glu Leu 
            260                 265                 270


Asn Cys Phe Val Leu Gln Met Asp Tyr Lys Gly Asp Ala Val Ala Phe 
        275                 280                 285


Phe Val Leu Pro Ser Lys Gly Lys Met Arg Gln Leu Glu Gln Ala Leu 
    290                 295                 300


Ser Ala Arg Thr Leu Arg Lys Trp Ser His Ser Leu Gln Lys Arg Trp 
305                 310                 315                 320


Ile Glu Val Phe Ile Pro Arg Phe Ser Ile Ser Ala Ser Tyr Asn Leu 
                325                 330                 335


Glu Thr Ile Leu Pro Lys Met Gly Ile Gln Asn Val Phe Asp Lys Asn 
            340                 345                 350


Ala Asp Phe Ser Gly Ile Ala Lys Arg Asp Ser Leu Gln Val Ser Lys 
        355                 360                 365


Ala Thr His Lys Ala Val Leu Asp Val Ser Glu Glu Gly Thr Glu Ala 
    370                 375                 380


Thr Ala Ala Thr Thr Thr Lys Phe Ile Val Arg Ser Lys Asp Gly Pro 
385                 390                 395                 400


Ser Tyr Phe Thr Val Ser Phe Asn Arg Thr Phe Leu Met Met Ile Thr 
                405                 410                 415


Asn Lys Ala Thr Asp Gly Ile Leu Phe Leu Gly Lys Val Glu Asn Pro 
            420                 425                 430


Thr Lys Ser 
        435


<210>  973
<211>  2087
<212>  DNA
<213>  Homo sapiens

<400>  973
ctcccaggtg cctggcagag agtcctcacc agccccctgc cggatgtctg gctggcatct     60

gaggggactg aacatggcaa gaagcaaaac agcagcacaa gaaaccagtt tcttcatctg    120

aaaccgagca ggctctactc cagaacagaa cccacagtcc caggcgctgg gccttcttct    180

taagttggga aatcactcat ccccaggaga aaaaaagagc aaaagcttcc agtactgggg    240

atgtggggag aggtttttta aaaatatcag cccaatatat gggaaaatat gggatgcagg    300

catccccagg tgtcaagcgt ccagatccgt agacacactg ggacgatggt gatcagtatc    360

actccctctg actcatcggc cctacagaga agacaccatg ctggtgcaca gtcggtgcca    420

aacccgcgtt tgtaaatgaa taagtgttgc tgccctggtg gaagcccagc tcatgtggag    480

gaagccagct tgcagagaga gcaagaacag agccagcaca cacattggag caaaggcaag    540

ggcagatgga aagttctggc ggcatcatgc caaggctccc atccgaggcc tccctgaacc    600

ccactctctc ggcgccacct tggatgctgc gggctggtac attccccact tgcaaaactc    660

tgtggggctg ggttcctctc ttttctttcc aaatatccca ggaagtggat ggttttatcc    720

aaattcagca gacgagtaaa aagagtcttc gggaggtgca atagctttct aggaatgagg    780

atattcttca aggaaaatga accccacact aggcctggcc atttttctgg ctgttctcct    840

cacggtgaaa ggtcttctaa agccgagctt ctcaccaagg aattataaag ctttgagcga    900

ggtccaagga tggaagcaaa ggatggcagc caaggagctt gcaaggcaga acatggactt    960

aggctttaag ctgctcaaga agctggcctt ttacaaccct ggcaggaaca tcttcctatc   1020

ccccttgagc atctctacag ctttctccat gctgtgcctg ggtgcccagg acagcaccct   1080

ggacgagatc aagcaggggt tcaacttcag aaagatgcca gaaaaagatc ttcatgaggg   1140

cttccattac atcatccacg agctgaccca gaagacccag gacctcaaac tgagcattgg   1200

gaacacgctg ttcattgacc agaggctgca gccacagcgt aagtttttgg aagatgccaa   1260

gaacttttac agtgccgaaa ccatccttac caactttcag aatttggaaa tggctcagaa   1320

gcagatcaat gactttatca gtcaaaaaac ccatgggaaa attaacaacc tgatcgagaa   1380

tatagacccc ggcactgtga tgcttcttgc aaattatatt ttctttcgag ccaggtggaa   1440

acatgagttt gatccaaatg taactaaaga ggaagatttc tttctggaga aaaacagttc   1500

agtcaaggtg cccatgatgt tccgtagtgg catataccaa gttggctatg acgataagct   1560

ctcttgcacc atcctggaaa taccctacca gaaaaatatc acagccatct tcatccttcc   1620

tgatgagggc aagctgaagc acttggagaa gggattgcag gtggacactt tctccagatg   1680

gaaaacatta ctgtcacgca gggtcgtaga cgtgtctgta cccagactcc acatgacggg   1740

caccttcgac ctgaagaaga ctctctccta cataggtgtc tccaaaatct ttgaggaaca   1800

tggtgatctc accaagatcg cccctcatcg cagcctgaaa gtgggcgagg ctgtgcacaa   1860

ggctgagctg aagatggatg agaggggtac ggaaggggcc gctggcaccg gagcacagac   1920

tctgcccatg gagacaccac tcgtcgtcaa gatagacaaa ccctatctgc tgctgattta   1980

cagcgagaaa ataccttccg tgctcttcct gggaaagatt gttaacccta ttggaaaata   2040

aaggagaatt cctgcttgcc aaaaaaaaaa aaaaaaaaaa aaaaaaa                 2087


<210>  974
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  974

Met Asn Pro Thr Leu Gly Leu Ala Ile Phe Leu Ala Val Leu Leu Thr 
1               5                   10                  15


Val Lys Gly Leu Leu Lys Pro Ser Phe Ser Pro Arg Asn Tyr Lys Ala 
            20                  25                  30


Leu Ser Glu Val Gln Gly Trp Lys Gln Arg Met Ala Ala Lys Glu Leu 
        35                  40                  45


Ala Arg Gln Asn Met Asp Leu Gly Phe Lys Leu Leu Lys Lys Leu Ala 
    50                  55                  60


Phe Tyr Asn Pro Gly Arg Asn Ile Phe Leu Ser Pro Leu Ser Ile Ser 
65                  70                  75                  80


Thr Ala Phe Ser Met Leu Cys Leu Gly Ala Gln Asp Ser Thr Leu Asp 
                85                  90                  95


Glu Ile Lys Gln Gly Phe Asn Phe Arg Lys Met Pro Glu Lys Asp Leu 
            100                 105                 110


His Glu Gly Phe His Tyr Ile Ile His Glu Leu Thr Gln Lys Thr Gln 
        115                 120                 125


Asp Leu Lys Leu Ser Ile Gly Asn Thr Leu Phe Ile Asp Gln Arg Leu 
    130                 135                 140


Gln Pro Gln Arg Lys Phe Leu Glu Asp Ala Lys Asn Phe Tyr Ser Ala 
145                 150                 155                 160


Glu Thr Ile Leu Thr Asn Phe Gln Asn Leu Glu Met Ala Gln Lys Gln 
                165                 170                 175


Ile Asn Asp Phe Ile Ser Gln Lys Thr His Gly Lys Ile Asn Asn Leu 
            180                 185                 190


Ile Glu Asn Ile Asp Pro Gly Thr Val Met Leu Leu Ala Asn Tyr Ile 
        195                 200                 205


Phe Phe Arg Ala Arg Trp Lys His Glu Phe Asp Pro Asn Val Thr Lys 
    210                 215                 220


Glu Glu Asp Phe Phe Leu Glu Lys Asn Ser Ser Val Lys Val Pro Met 
225                 230                 235                 240


Met Phe Arg Ser Gly Ile Tyr Gln Val Gly Tyr Asp Asp Lys Leu Ser 
                245                 250                 255


Cys Thr Ile Leu Glu Ile Pro Tyr Gln Lys Asn Ile Thr Ala Ile Phe 
            260                 265                 270


Ile Leu Pro Asp Glu Gly Lys Leu Lys His Leu Glu Lys Gly Leu Gln 
        275                 280                 285


Val Asp Thr Phe Ser Arg Trp Lys Thr Leu Leu Ser Arg Arg Val Val 
    290                 295                 300


Asp Val Ser Val Pro Arg Leu His Met Thr Gly Thr Phe Asp Leu Lys 
305                 310                 315                 320


Lys Thr Leu Ser Tyr Ile Gly Val Ser Lys Ile Phe Glu Glu His Gly 
                325                 330                 335


Asp Leu Thr Lys Ile Ala Pro His Arg Ser Leu Lys Val Gly Glu Ala 
            340                 345                 350


Val His Lys Ala Glu Leu Lys Met Asp Glu Arg Gly Thr Glu Gly Ala 
        355                 360                 365


Ala Gly Thr Gly Ala Gln Thr Leu Pro Met Glu Thr Pro Leu Val Val 
    370                 375                 380


Lys Ile Asp Lys Pro Tyr Leu Leu Leu Ile Tyr Ser Glu Lys Ile Pro 
385                 390                 395                 400


Ser Val Leu Phe Leu Gly Lys Ile Val Asn Pro Ile Gly Lys 
                405                 410


<210>  975
<211>  3780
<212>  DNA
<213>  Homo sapiens

<400>  975
acatgtcctt aaccttggca caacaaatct ctaaatcgat tgagacctgt ctcagatact     60

tcttggttta caagatggag gctgaaatta aagagaaaga tcctcactca actcacagag    120

gagcagaatg ggaagaggac ttagtgagaa ttccctgaac acaggagaaa accgaagccc    180

agagagtgga tggccaagtc caaggtcaca cagccaagtg catccgagca gcgcaggatc    240

caggtttcct gccccagtgc tctttctgca gcccatgcca cctgttttca tgctatctca    300

gttcaccttc cagctacaca cctgcaatca gaaacagaaa gtctgagagt gtgtgtggag    360

ccaaagaggg gacagcagtg gtgaggccag tttcatgtct tgtgatttat tttctccctt    420

tctttttgga ctttaatctt aagtggacag caatttggaa cagtgtcagc accttgttgg    480

attgtgctgt ttgggagagg tgacacagag tattttaaaa gagcaggtta agaacttttc    540

acaaggaatc aattgagaga aaataaaata gaaacagact gtcccacatt tgggctgagc    600

accaaacaca tttttttttt tttttttgag actgagtctt gctctgtcac tcaggctgga    660

atgcagtggc gcgatctcgg ctcactgcag ccttcacctc ccgggttcaa gtgattcttc    720

tgcctcagcc tcccaagtag ctgggattac aggtgcccac caccatgcca ggctaatttt    780

tgtattttta gtagagacga ggtttcacca tgttggccag gctggtcttg aactcctgac    840

caagtgatcc acctgcttcg gcctcccaaa gtgctgggat tacaggcacg agccaccgca    900

cctggcctca aacaagcttt ttaattgcat tcagaagtgc accaactagg cacagacctc    960

tggcatggag acagaatggg aggttcttgg tgtctggcct ggtcttgcag aaatcaggga   1020

gttgtgggga ccaggcagcc actgtgcatc agataggagt ttcagcagca ggcaacagaa   1080

agcctgccaa tgtagctgaa ataagaaggg cttattttta tccctgaaca gaagcttcca   1140

gcactggttc atcagatcag ggcactgagc tggcatcccc atttatacag ttttcctttc   1200

cttcaccttt gtaagatgcc tggcacagct ctgagcatca aatatctgtg ccatgtggga   1260

gcacacgagg ggacaagtgg ggaatagggt ctcctctgtc ctctgtcccc aggctggctt   1320

ctctcgtggt agaaggaccc ccacagcacc aggcctcata actaccctgc tggtaaactg   1380

caggtgctgt cacggcttcc tgccttcgta tatgaaatgt tccttggcag ctggactgct   1440

gtttgtttac cgcacgcaca gctctgctgc ctcttggtta caccagtgag ctattgctcc   1500

atgacaagcc acaccgaaat gtagcaagca cttattgttg cccacatgtg tcaagtcagt   1560

tgagtgtttc tgccaaccgg ggcctggctt ggcccacctt ggctgagctt gctctggtgc   1620

tagggtcagc tagacaggtc ggcaggagac cagctgctct agaagagcct ggacaggatg   1680

aattggttct ccttccacgt gcatcttgca tccctccagc caaggatttg aacccaggtc   1740

tcgtctgact ccaaatgcac caagaggatg gagcccagag tgacacagag gaagaggccc   1800

ctggatggat gcatggggaa gatcacggga attacaagtg acatcctgaa gtatgatcac   1860

aaatgtttca aattaagcct tcctgctaag tttccagagg tgtgtggctc ggacgaagtg   1920

tttccagacc ctgatctact gcatgtcctg cctgttgctg gttctttgca gcagtccatt   1980

gaccaatgct gtctacagct tgagagcctc tgcaggccag ggctgctctg tgcacatcct   2040

acgttactat tcaaactgca cagcagcatg aaaaacaggc ccttcttttc tctcatttac   2100

acatatgtga agaagacaca gcaagtgaga aaacgtgacc gaaagccacg cggacaggtg   2160

gccgcagggc caaacccaac ttccgtgatg tgatctggct acagtttgga gcccacatat   2220

ttcaatagtt atccccaggc ctggcacgtc aaagaggctc cagaaatgtt tgctgagtga   2280

gtgatgaatc agcaatttct gattttctcc taaacttaga gaataagtgg cttgtctgca   2340

gtcacccagg gcgtccctga cagaggtaca agtaaagccc agatctctgc atctctggtt   2400

caaggccttt tgtactacac accgctgtct ctttgtcatc attaaaagca aggctcaagg   2460

gacatgtttt ctagccttag ttccccatct acaaaatggg cctcatggaa tggaatgtct   2520

ccacttcact ccagcatcaa caagtgggga attctgatgg attcaattcg acttctttcc   2580

atgggcgtgt tctaagcagc ctctttgttc cagaagctgc cctcagccag agttggataa   2640

gccaatcctc actccccagc ctcctctgga tagggatgaa gaccccactg gggttggaag   2700

tgcagaggca gacaggtgta tggagtcacc tgtaaattga ttcaagtgag ccaggaaagc   2760

agcaaaggaa agagaaacct gagtgacgac gtggtggagg aacagggctg gaaagaggct   2820

gctggctgtc tggcttcgca gctctggcct cctaatcagc ctcgctcttg tctctggtgt   2880

tctctggctc ttgtccatct gtctgtgttt ctttttgcca gctattgact aatctttgct   2940

gaagctgagc tagaattctg gtgtttataa gcaggtaact agctgagcac tagttgataa   3000

ctttggagtt agtggataac cacagggctg ggctactaag ctttttcagt tgaaaaataa   3060

ataaataaat aaataaacac cacacccagc taatttttgt atttttagta gagacagggt   3120

ttcaccgtgt tagccaggat ggactccatc tcctgacctc gtgatccgcc tacctcggcc   3180

tcccaaagtg ctgggattac aggcgtgagc caccacgccc ggtcaccttt gtcctgtttt   3240

ctacaggtta gaagcaaggc acaagtcata cctacattca aggagagggg accatgcaaa   3300

ggataaactg cagagagaca acagatttac atcccagaca cattcacact gggccaagag   3360

cagctgccat tgcagattcg agtcacgtcc ttttttcctt ccttctcctt cttggagtta   3420

caacagaagc tggggaggtg agagtgcaga aaggacgtgg atgaagcaga gaggcacgtg   3480

cctgtctcat tcgcctctgg atctgctgca tccaggactg tgccagcaca aagtgggagc   3540

ccgataaata tttattgaag aaatgaaagg tgacaaaagg cagaaggagg gagaccccaa   3600

aaagagcagc acaggaagct gccccctcaa acactaaagg ctcctggagc tattcacagt   3660

gctggggaac aaccagagga ggaggaggac agagggagag aatacttttt ttaaaaatcc   3720

caaacaaaac caaattctat acatgtatat ctcgagtgag taaatgtgta acactcagca   3780


<210>  976
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  976

Met Glu Pro Arg Val Thr Gln Arg Lys Arg Pro Leu Asp Gly Cys Met 
1               5                   10                  15


Gly Lys Ile Thr Gly Ile Thr Ser Asp Ile Leu Lys Tyr Asp His Lys 
            20                  25                  30


Cys Phe Lys Leu Ser Leu Pro Ala Lys Phe Pro Glu Val Cys Gly Ser 
        35                  40                  45


Asp Glu Val Phe Pro Asp Pro Asp Leu Leu His Val Leu Pro Val Ala 
    50                  55                  60


Gly Ser Leu Gln Gln Ser Ile Asp Gln Cys Cys Leu Gln Leu Glu Ser 
65                  70                  75                  80


Leu Cys Arg Pro Gly Leu Leu Cys Ala His Pro Thr Leu Leu Phe Lys 
                85                  90                  95


Leu His Ser Ser Met Lys Asn Arg Pro Phe Phe Ser Leu Ile Tyr Thr 
            100                 105                 110


Tyr Val Lys Lys Thr Gln Gln Val Arg Lys Arg Asp Arg Lys Pro Arg 
        115                 120                 125


Gly Gln Val Ala Ala Gly Pro Asn Pro Thr Ser Val Met 
    130                 135                 140


<210>  977
<211>  4232
<212>  DNA
<213>  Homo sapiens

<400>  977
acatgtcctt aaccttggca caacaaatct ctaaatcgat tgagacctgt ctcagatact     60

tcttggttta caagatggag gctgaaatta aagagaaaga tcctcactca actcacagag    120

gagcagaatg ggaagaggac ttagtgagaa ttccctgaac acaggagaaa accgaagccc    180

agagagtgga tggccaagtc caaggtcaca cagccaagtg catccgagca gcgcaggatc    240

caggtttcct gccccagtgc tctttctgca gcccatgcca cctgttttca tgctatctca    300

gttcaccttc cagctacaca cctgcaatca gaaacagaaa gtctgagagt gtgtgtggag    360

ccaaagaggg gacagcagtg gtgaggccag tttcatgtct tgtgatttat tttctccctt    420

tctttttgga ctttaatctt aagtggacag caatttggaa cagtgtcagc accttgttgg    480

attgtgctgt ttgggagagg tgacacagag tattttaaaa gagcaggtta agaacttttc    540

acaaggaatc aattgagaga aaataaaata gaaacagact gtcccacatt tgggctgagc    600

accaaacaca tttttttttt tttttttgag actgagtctt gctctgtcac tcaggctgga    660

atgcagtggc gcgatctcgg ctcactgcag ccttcacctc ccgggttcaa gtgattcttc    720

tgcctcagcc tcccaagtag ctgggattac aggtgcccac caccatgcca ggctaatttt    780

tgtattttta gtagagacga ggtttcacca tgttggccag gctggtcttg aactcctgac    840

caagtgatcc acctgcttcg gcctcccaaa gtgctgggat tacaggcacg agccaccgca    900

cctggcctca aacaagcttt ttaattgcat tcagaagtgc accaactagg cacagacctc    960

tggcatggag acagaatggg aggttcttgg tgtctggcct ggtcttgcag aaatcaggga   1020

gttgtgggga ccaggcagcc actgtgcatc agataggagt ttcagcagca ggcaacagaa   1080

agcctgccaa tgtagctgaa ataagaaggg cttattttta tccctgaaca gaagcttcca   1140

gcactggttc atcagatcag ggcactgagc tggcatcccc atttatacag ttttcctttc   1200

cttcaccttt gtaagatgcc tggcacagct ctgagcatca aatatctgtg ccatgtggga   1260

gcacacgagg ggacaagtgg ggaatagggt ctcctctgtc ctctgtcccc aggctggctt   1320

ctctcgtggt agaaggaccc ccacagcacc aggcctcata actaccctgc tggtaaactg   1380

caggtgctgt cacggcttcc tgccttcgta tatgaaatgt tccttggcag ctggactgct   1440

gtttgtttac cgcacgcaca gctctgctgc ctcttggtta caccagtgag ctattgctcc   1500

atgacaagcc acaccgaaat gtagcaagca cttattgttg cccacatgtg tcaagtcagt   1560

tgagtgtttc tgccaaccgg ggcctggctt ggcccacctt ggctgagctt gctctggtgc   1620

tagggtcagc tagacaggtc ggcaggagac cagctgctct agaagagcct ggacaggatg   1680

aattggttct ccttccacgt gcatcttgca tccctccagc caaggatttg aacccaggtc   1740

tcgtctgact ccaaatgcac caagaggatg gagcccagag tgacacagag gaagaggccc   1800

ctggatggat gcatggggaa gatcacggga attacaagtg acatcctgaa gtatgatcac   1860

aaatgtttca aattaagcct tcctgctaag tttccagagg tgtgtggctc ggacgaagtg   1920

tttccagacc ctgatctact gcatgtcctg cctgttgctg gttctttgca gcagtccatt   1980

gaccaatgct gtctacagct tgagagcctc tgcaggccag ggctgctctg tgcacatcct   2040

acgttactat tcaaactgca cagcagcatg aaaaacaggc ccttcttttc tctcatttac   2100

acatatgtga agaagacaca gcaagtgaga aaacgtgacc gaaagccacg cggacaggtg   2160

gccgcagggc caaacccaac ttccgtgatg tgatctggct acagtttgga gcccacatat   2220

ttcaatagtt atccccaggc ctggcacgtc aaagaggctc cagaaatgtt tgctgagtga   2280

gtgatgaatc agcaatttct gattttctcc taaacttaga gaataagtgg cttgtctgca   2340

gtcacccagg gcgtccctga cagaggtaca agtaaagccc agatctctgc atctctggtt   2400

caaggccttt tgtactacac accgctgtct ctttgtcatc attaaaagca aggctcaagg   2460

gacatgtttt ctagccttag ttccccatct acaaaatggg cctcatggaa tggaatgtct   2520

ccacttcact ccagcatcaa caagtgggga attctgatgg attcaattcg acttctttcc   2580

atgggcgtgt tctaagcagc ctctttgttc cagaagctgc cctcagccag agttggataa   2640

gccaatcctc actccccagc ctcctctgga tagggatgaa gaccccactg gggttggaag   2700

tgcagaggca gacaggtgta tggagtcacc tgtaaattga ttcaagtgag ccaggaaagc   2760

agcaaaggaa agagaaacct gagtgacgac gtggtggagg aacagggctg gaaagaggct   2820

gctggctgtc tggcttcgca gctctggcct cctaatcagc ctcgctcttg tctctggtgt   2880

tctctggctc ttgtccatct gtctgtgttt ctttttgcca gctattgact aatctttgct   2940

gaagctgagc tagaattctg gtgtttataa gcaggtaact agctgagcac tagttgataa   3000

ctttggagtt agtggataac cacagggctg ggctactaag ctttttcagt tgaaaaataa   3060

ataaataaat aaataaacac cacacccagc taatttttgt atttttagta gagacagggt   3120

ttcaccgtgt tagccaggat ggactccatc tcctgacctc gtgatccgcc tacctcggcc   3180

tcccaaagtg ctgggattac aggcgtgagc caccacgccc ggtcaccttt gtcctgtttt   3240

ctacaggtta gaagcaaggc acaagtcata cctacattca aggagagggg accatgcaaa   3300

ggataaactg cagaaaggac gtggatgaag cagagaggca cgtgcctgtc tcattcgcct   3360

ctggatctgc tgcatccagg actgtgccag cacaaagtgg gagcccgata aatatttatt   3420

gaagaaatga aaggtgacaa aaggcagaag gagggagacc ccaaaaagag ttacactgga   3480

agaagagccc ctccttcctt caagccaagt catccccttg ggctctcacc acttcagttt   3540

ataccttgcc tgtagtccag tctctccagc atcaattcca tcagcacaaa gacataattt   3600

aattccttct accttaaaaa aaaaaaaaaa aaaaaaacag ctctccctct cttagggtga   3660

gatgaagtgg ttggcaacag gccaatgcta ctttcagagg cgtttgaatc agagtgactc   3720

cattttgaat aggggttgag taaaataagg ctgagaccta ctgggctgca ttcccatgag   3780

cttaggcatt ctaagtcaca ggatgagaca ggaggtcagc acaagataca cgtcacaaag   3840

accttgctga taaaacagat tgtgataaga aaagccagtc aaaacccacc aaaaccaaga   3900

tggcgacaaa agtgatctct ggttgtcctc actgctgatt attcactaat tataaaatta   3960

acatgataaa agacactccc accagcaccg tgacagttta caaatgacat ggacacatca   4020

ggaagttacc ctatatgtct aaaaggggag gagccctcca ttccaattgt ccaccccttt   4080

cctggaaaac tcatgaataa tccacccctt gtttagcata taatcaagaa ataaccatga   4140

aaatagccaa ccagcagccc tcagggctgc tttgcctatg gagtagccat tctatattcc   4200

tttactttct taataaactt gctttcactt ta                                 4232


<210>  978
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  978

Met Glu Pro Arg Val Thr Gln Arg Lys Arg Pro Leu Asp Gly Cys Met 
1               5                   10                  15


Gly Lys Ile Thr Gly Ile Thr Ser Asp Ile Leu Lys Tyr Asp His Lys 
            20                  25                  30


Cys Phe Lys Leu Ser Leu Pro Ala Lys Phe Pro Glu Val Cys Gly Ser 
        35                  40                  45


Asp Glu Val Phe Pro Asp Pro Asp Leu Leu His Val Leu Pro Val Ala 
    50                  55                  60


Gly Ser Leu Gln Gln Ser Ile Asp Gln Cys Cys Leu Gln Leu Glu Ser 
65                  70                  75                  80


Leu Cys Arg Pro Gly Leu Leu Cys Ala His Pro Thr Leu Leu Phe Lys 
                85                  90                  95


Leu His Ser Ser Met Lys Asn Arg Pro Phe Phe Ser Leu Ile Tyr Thr 
            100                 105                 110


Tyr Val Lys Lys Thr Gln Gln Val Arg Lys Arg Asp Arg Lys Pro Arg 
        115                 120                 125


Gly Gln Val Ala Ala Gly Pro Asn Pro Thr Ser Val Met 
    130                 135                 140


<210>  979
<211>  3398
<212>  DNA
<213>  Homo sapiens

<400>  979
acatgtcctt aaccttggca caacaaatct ctaaatcgat tgagacctgt ctcagatact     60

tcttggttta caagatggag gctgaaatta aagagaaaga tcctcactca actcacagag    120

gagcagaatg ggaagaggac ttagtgagaa ttccctgaac acaggagaaa accgaagccc    180

agagagtgga tggccaagtc caaggtcaca cagccaagtg catccgagca gcgcaggatc    240

caggtttcct gccccagtgc tctttctgca gcccatgcca cctgttttca tgctatctca    300

gttcaccttc cagctacaca cctgcaatca gaaacagaaa gtctgagagt gtgtgtggag    360

ccaaagaggg gacagcagtg gtgaggccag tttcatgtct tgtgatttat tttctccctt    420

tctttttgga ctttaatctt aagtggacag caatttggaa cagtgtcagc accttgttgg    480

attgtgctgt ttgggagagg tgacacagag tattttaaaa gagcaggtta agaacttttc    540

acaaggaatc aattgagaga aaataaaata gaaacagact gtcccacatt tgggctgagc    600

accaaacaca tttttttttt tttttttgag actgagtctt gctctgtcac tcaggctgga    660

atgcagtggc gcgatctcgg ctcactgcag ccttcacctc ccgggttcaa gtgattcttc    720

tgcctcagcc tcccaagtag ctgggattac aggtgcccac caccatgcca ggctaatttt    780

tgtattttta gtagagacga ggtttcacca tgttggccag gctggtcttg aactcctgac    840

caagtgatcc acctgcttcg gcctcccaaa gtgctgggat tacaggcacg agccaccgca    900

cctggcctca aacaagcttt ttaattgcat tcagaagtgc accaactagg cacagacctc    960

tggcatggag acagaatggg aggttcttgg tgtctggcct ggtcttgcag aaatcaggga   1020

gttgtgggga ccaggcagcc actgtgcatc agataggagt ttcagcagca ggcaacagaa   1080

agcctgccaa tgtagctgaa ataagaaggg cttattttta tccctgaaca gaagcttcca   1140

gcactggttc atcagatcag ggcactgagc tggcatcccc atttatacag ttttcctttc   1200

cttcaccttt gtaagatgcc tggcacagct ctgagcatca aatatctgtg ccatgtggga   1260

gcacacgagg ggacaagtgg ggaatagggt ctcctctgtc ctctgtcccc aggctggctt   1320

ctctcgtggt agaaggaccc ccacagcacc aggcctcata actaccctgc tggtaaactg   1380

caggtgctgt cacggcttcc tgccttcgta tatgaaatgt tccttggcag ctggactgct   1440

gtttgtttac cgcacgcaca gctctgctgc ctcttggtta caccagtgag ctattgctcc   1500

atgacaagcc acaccgaaat gtagcaagca cttattgttg cccacatgtg tcaagtcagt   1560

tgagtgtttc tgccaaccgg ggcctggctt ggcccacctt ggctgagctt gctctggtgc   1620

tagggtcagc tagacaggtc ggcaggagac cagctgctct agaagagcct ggacaggatg   1680

aattggttct ccttccacgt gcatcttgca tccctccagc caaggatttg aacccaggtc   1740

tcgtctgact ccaaatgcac caagaggatg gagcccagag tgacacagag gaagaggccc   1800

ctggatggat gcatggggaa gatcacggga attacaagtg acatcctgaa gtatgatcac   1860

aaatgtttca aattaagcct tcctgctaag tttccagagg tgtgtggctc ggacgaagtg   1920

tttccagacc ctgatctact gcatgtcctg cctgttgctg gttctttgca gcagtccatt   1980

gaccaatgct gtctacagct tgagagcctc tgcaggccag ggctgctctg tgcacatcct   2040

acgttactat tcaaactgca cagcagcatg aaaaacaggc ccttcttttc tctcatttac   2100

acatatgtga agaagacaca gcaagtgaga aaacgtgacc gaaagccacg cggacaggtg   2160

gccgcagggc caaacccaac ttccgtgatg tgatctggct acagtttgga gcccacatat   2220

ttcaatagtt atccccaggc ctggcacgtc aaagaggctc cagaaatgtt tgctgagtta   2280

gaagcaaggc acaagtcata cctacattca aggagagggg accatgcaaa ggataaactg   2340

cagagagaca acagatttac atcccagaca cattcacact gggccaagag cagctgccat   2400

tgcagattcg agtcacgtcc ttttttcctt ccttctcctt cttggagtta caacagaagc   2460

tggggaggtg agagtgcaga aaggacgtgg atgaagcaga gaggcacgtg cctgtctcat   2520

tcgcctctgg atctgctgca tccaggactg tgccagcaca aagtgggagc ccgataaata   2580

tttattgaag aaatgaaagg tgacaaaagg cagaaggagg gagaccccaa aaagagttac   2640

actggaagaa gagcccctcc ttccttcaag ccaagtcatc cccttgggct ctcaccactt   2700

cagtttatac cttgcctgta gtccagtctc tccagcatca attccatcag cacaaagaca   2760

taatttaatt ccttctacct taaaaaaaaa aaaaaaaaaa aaacagctct ccctctctta   2820

gggtgagatg aagtggttgg caacaggcca atgctacttt cagaggcgtt tgaatcagag   2880

tgactccatt ttgaataggg gttgagtaaa ataaggctga gacctactgg gctgcattcc   2940

catgagctta ggcattctaa gtcacaggat gagacaggag gtcagcacaa gatacacgtc   3000

acaaagacct tgctgataaa acagattgtg ataagaaaag ccagtcaaaa cccaccaaaa   3060

ccaagatggc gacaaaagtg atctctggtt gtcctcactg ctgattattc actaattata   3120

aaattaacat gataaaagac actcccacca gcaccgtgac agtttacaaa tgacatggac   3180

acatcaggaa gttaccctat atgtctaaaa ggggaggagc cctccattcc aattgtccac   3240

ccctttcctg gaaaactcat gaataatcca ccccttgttt agcatataat caagaaataa   3300

ccatgaaaat agccaaccag cagccctcag ggctgctttg cctatggagt agccattcta   3360

tattccttta ctttcttaat aaacttgctt tcacttta                           3398


<210>  980
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  980

Met Glu Pro Arg Val Thr Gln Arg Lys Arg Pro Leu Asp Gly Cys Met 
1               5                   10                  15


Gly Lys Ile Thr Gly Ile Thr Ser Asp Ile Leu Lys Tyr Asp His Lys 
            20                  25                  30


Cys Phe Lys Leu Ser Leu Pro Ala Lys Phe Pro Glu Val Cys Gly Ser 
        35                  40                  45


Asp Glu Val Phe Pro Asp Pro Asp Leu Leu His Val Leu Pro Val Ala 
    50                  55                  60


Gly Ser Leu Gln Gln Ser Ile Asp Gln Cys Cys Leu Gln Leu Glu Ser 
65                  70                  75                  80


Leu Cys Arg Pro Gly Leu Leu Cys Ala His Pro Thr Leu Leu Phe Lys 
                85                  90                  95


Leu His Ser Ser Met Lys Asn Arg Pro Phe Phe Ser Leu Ile Tyr Thr 
            100                 105                 110


Tyr Val Lys Lys Thr Gln Gln Val Arg Lys Arg Asp Arg Lys Pro Arg 
        115                 120                 125


Gly Gln Val Ala Ala Gly Pro Asn Pro Thr Ser Val Met 
    130                 135                 140


<210>  981
<211>  3663
<212>  DNA
<213>  Homo sapiens

<400>  981
acatgtcctt aaccttggca caacaaatct ctaaatcgat tgagacctgt ctcagatact     60

tcttggttta caagatggag gctgaaatta aagagaaaga tcctcactca actcacagag    120

gagcagaatg ggaagaggac ttagtgagaa ttccctgaac acaggagaaa accgaagccc    180

agagagtgga tggccaagtc caaggtcaca cagccaagtg catccgagca gcgcaggatc    240

caggtttcct gccccagtgc tctttctgca gcccatgcca cctgttttca tgctatctca    300

gttcaccttc cagctacaca cctgcaatca gaaacagaaa gtctgagagt gtgtgtggag    360

ccaaagaggg gacagcagtg gtgaggccag tttcatgtct tgtgatttat tttctccctt    420

tctttttgga ctttaatctt aagtggacag caatttggaa cagtgtcagc accttgttgg    480

attgtgctgt ttgggagagg tgacacagag tattttaaaa gagcaggtta agaacttttc    540

acaaggaatc aattgagaga aaataaaata gaaacagact gtcccacatt tgggctgagc    600

accaaacaca tttttttttt tttttttgag actgagtctt gctctgtcac tcaggctgga    660

atgcagtggc gcgatctcgg ctcactgcag ccttcacctc ccgggttcaa gtgattcttc    720

tgcctcagcc tcccaagtag ctgggattac aggtgcccac caccatgcca ggctaatttt    780

tgtattttta gtagagacga ggtttcacca tgttggccag gctggtcttg aactcctgac    840

caagtgatcc acctgcttcg gcctcccaaa gtgctgggat tacaggcacg agccaccgca    900

cctggcctca aacaagcttt ttaattgcat tcagaagtgc accaactagg cacagacctc    960

tggcatggag acagaatggg aggttcttgg tgtctggcct ggtcttgcag aaatcaggga   1020

gttgtgggga ccaggcagcc actgtgcatc agataggagt ttcagcagca ggcaacagaa   1080

agcctgccaa tgtagctgaa ataagaaggg cttattttta tccctgaaca gaagcttcca   1140

gcactggttc atcagatcag ggcactgagc tggcatcccc atttatacag ttttcctttc   1200

cttcaccttt gtaagatgcc tggcacagct ctgagcatca aatatctgtg ccatgtggga   1260

gcacacgagg ggacaagtgg ggaatagggt ctcctctgtc ctctgtcccc aggctggctt   1320

ctctcgtggt agaaggaccc ccacagcacc aggcctcata actaccctgc tggtaaactg   1380

caggtgctgt cacggcttcc tgccttcgta tatgaaatgt tccttggcag ctggactgct   1440

gtttgtttac cgcacgcaca gctctgctgc ctcttggtta caccagtgag ctattgctcc   1500

atgacaagcc acaccgaaat gtagcaagca cttattgttg cccacatgtg tcaagtcagt   1560

tgagtgtttc tgccaaccgg ggcctggctt ggcccacctt ggctgagctt gctctggtgc   1620

tagggtcagc tagacaggtc ggcaggagac cagctgctct agaagagcct ggacaggatg   1680

aattggttct ccttccacgt gcatcttgca tccctccagc caaggatttg aacccaggtc   1740

tcgtctgact ccaaatgcac caagaggatg gagcccagag tgacacagag gaagaggccc   1800

ctggatggat gcatggggaa ggttagaagc aaggcacaag tcatacctac attcaaggag   1860

aggggaccat gcaaaggata aactgcagag agacaacaga tttacatccc agacacattc   1920

acactgggcc aagagcagct gccattgcag attcgagtca cgtccttttt tccttccttc   1980

tccttcttgg agttacaaca gaagctgggg aggtgagagt gcagaaagga cgtggatgaa   2040

gcagagaggc acgtgcctgt ctcattcgcc tctggatctg ctgcatccag gactgtgcca   2100

gcacaaagtg ggagcccgat aaatatttat tgaagaaatg aaaggtgaca aaaggcagaa   2160

ggagggagac cccaaaaaga gagatgggat cccactatat tgcacaggct ggtctcaaac   2220

tcctgagctc aagcgatcct cctgccttgg cctcccacgg tgctgagact acaggtgtga   2280

gccaccactc ccagcctgat ttatatttta taaagaggca acgatggagt acacagctga   2340

gcaatctctt gcatttctgg accttgagca tcaggaagct tagggagggt gaaaactcag   2400

aagaaagctc agagttgaga cctttgattt tttgcccaga gagtccagct aacacacttt   2460

ataacccaaa aggccttaca aatatttcag agcagaggca gcatttttgc actggataaa   2520

caaaggtacg gtaatttctt catagtttat tttcattaca agtaattctt ttcctgaaga   2580

aaaatttata tttcagattt atttcccctc tcaaagggga ggggagttat aatattctgt   2640

ttccatagca ccattcctca agatcaaacc caggcaggca tttttacagc acacacttcc   2700

atatgtcatt gctaatcctc gcaaccttga ggaaactgag gtgcaaaggg gttgaggaat   2760

gtgttcacca tcccaaagcc aacgaagtgc cagaacccaa atccaagctt ggctgtctca   2820

tccccaagga cgtactcttt atgccgttcc ttatgacttt tcatgcagca ggtgcaaggc   2880

agcaagaatt tggctcttct gacatttatc aggcacctgg tatgtgccag gcctactgta   2940

aaccccaaga tgacatggtc catgtctatc cattcagcat cagagagact gttatcagga   3000

cttgaggcct gagacacagc cctgaatcag atgcaggcct ctggtgtttg caaaggatgc   3060

gtgagtatgt gtatgtgtat gcgtgcattg tgtgtagggg tgtgtgtatg ttgggggttg   3120

ggggcagaaa atgctccctg aactgttggt attaaggcag atctttgatg gagggactgg   3180

ggtgtggaga cttgaaccct agtttcaaag tggggacctc gaacactagt atggccagca   3240

gacaggctgg agttgctgaa ttgtcagcta ggtctttaat ccactcccct tctctaaatc   3300

agggtggaat tggactcagg gctggttcag ggctgaggtt tccgggggat gaatgattcc   3360

agacagtggg aaggggtgat ggatgatgaa cctggcaagt cacaggacta tggacttggc   3420

tgtatgttgc atgtatgtgt aagatctgag ttgagacctt tgatttttgc ccagaaagtc   3480

cagctaacat actatataag ccagtgagac cagccagtgt ctgttcattg cctctgcctt   3540

gcccctatgc ctgcccgcct cctatagcag gtccctatag cataatgaaa atgcgaacaa   3600

ccttttctct ggacactggg gaatctagtc tggtggataa agatggatgg ctgttaaacg   3660

atc                                                                 3663


<210>  982
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  982

Met Asp Ala Trp Gly Arg Leu Glu Ala Arg His Lys Ser Tyr Leu His 
1               5                   10                  15


Ser Arg Arg Gly Asp His Ala Lys Asp Lys Leu Gln Arg Asp Asn Arg 
            20                  25                  30


Phe Thr Ser Gln Thr His Ser His Trp Ala Lys Ser Ser Cys His Cys 
        35                  40                  45


Arg Phe Glu Ser Arg Pro Phe Phe Leu Pro Ser Pro Ser Trp Ser Tyr 
    50                  55                  60


Asn Arg Ser Trp Gly Gly Glu Ser Ala Glu Arg Thr Trp Met Lys Gln 
65                  70                  75                  80


Arg Gly Thr Cys Leu Ser His Ser Pro Leu Asp Leu Leu His Pro Gly 
                85                  90                  95


Leu Cys Gln His Lys Val Gly Ala Arg 
            100                 105


<210>  983
<211>  3307
<212>  DNA
<213>  Homo sapiens

<400>  983
gtcaacagcc acttcctccc tggggcttaa caggcattcc ttgaagcctg ccccgggcag     60

ttagtccttc ccttttgtgt gaactctcgg ctgttttcgt tgtctgcaca cagagcagtg    120

gtctagggag cgaagggttt tggaatggac cttttccttt cttagcttgc tgtagggatt    180

gtgcttcagc taagtaaagt ggaaaaacag aagtacaaaa gcaacagccc cagatctaag    240

ggcaccgtag ctctggaatc tggattttat tccagattca accctcagca gggagttgaa    300

gtggtcagcc ctgtgcttta caaggctgat tgggcagcac ccatagtaga attgtcaata    360

taaagtaatt gaaaggatca gaatccaggg ttttcgttgt ttttaagttt ttaagtttta    420

aaaacaaagt tgtttttgtt cgtttttaag tttacttctc tttaatcggt ctcactttat    480

tgaccaggct ggtttcgaac tcctgggctt aagtgatttc tcctgtctca gcttctcaaa    540

gtgctgggat tacaggcgtg agccgctgca cccagcccag aatccagttt taaagagttt    600

attcaagcca aaagctggga atggccatct gagaaacaca gactctagga aaatggggcc    660

agggccctga agttaaaagt taaagtcttg cttacatagg cagaaagcaa agacatttag    720

taaccttgta gaacattttc ttgtataact tttcttgttt taactttctt gtttaacatt    780

ttctatgcaa ggctggttta tgagttacaa cctataatta attataggtt gttcccctgc    840

ctccaccttg ttttcttttc tctacagctt gttttcattt cctttccaat ttaagaatgt    900

gtttaacatt ctatcccaga caatgtgatg gtcatgaagt ctctgtcaga gaggaaagag    960

ggagttaatc tataatgaag atcaacagtg aagaggaaag gggtcttccc tggaacgctt   1020

cagtcatata cgacatttta cacaacaata atggacctgt gtaaggaggt atgtgtggga   1080

gaagattcca gaaggtcttg agacactcca gatgaaggtt ggtgtggggc tgtgctgctg   1140

gagcaccaga gagtgaaaag aggttatctc cctctgtgcc aggccagagt gcagtggtgc   1200

aatcacggct cactgtagtc tcaacctcct gggctcaaga gatcctccca cttcagcctc   1260

ccaagcagct aagactacag ttattttatt cttatgagct tgtgggctcc atctaccaac   1320

ctctgggcaa atgctcatct gacttccata gacacacagc aagcagacaa ccacacaaag   1380

aggaagaggg agaatattta ccagccatgg aacatctgct ctgtgcttat atctcatatg   1440

cattatctct aattatcaaa agaaggttag aagcaaggca caagtcatac ctacattcaa   1500

ggagagggga ccatgcaaag gataaactgc agagagacaa cagatttaca tcccagacac   1560

attcacactg ggccaagagc agctgccatt gcagattcga gtcacgtcct tttttccttc   1620

cttctccttc ttggagttac aacagaagct ggggaggtga gagtgcagaa aggacgtgga   1680

tgaagcagag aggcacgtgc ctgtctcatt cgcctctgga tctgctgcat ccaggactgt   1740

gccagcacaa agtgggagcc cgataaatat ttattgaaga aatgaaaggt gacaaaaggc   1800

agaaggaggg agaccccaaa aagagagatg ggatcccact atattgcaca ggctggtctc   1860

aaactcctga gctcaagcga tcctcctgcc ttggcctccc acggtgctga gactacaggt   1920

gtgagccacc actcccagcc tgatttatat tttataaaga ggcaacgatg gagtacacag   1980

ctgagcaatc tcttgcattt ctggaccttg agcatcagga agcttaggga gggtgaaaac   2040

tcagaagaaa gctcagagtt gagacctttg attttttgcc cagagagtcc agctaacaca   2100

ctttataacc caaaaggcct tacaaatatt tcagagcaga ggcagcattt ttgcactgga   2160

taaacaaagg tacggtaatt tcttcatagt ttattttcat tacaagtaat tcttttcctg   2220

aagaaaaatt tatatttcag atttatttcc cctctcaaag gggaggggag ttataatatt   2280

ctgtttccat agcaccattc ctcaagatca aacccaggca ggcattttta cagcacacac   2340

ttccatatgt cattgctaat cctcgcaacc ttgaggaaac tgaggtgcaa aggggttgag   2400

gaatgtgttc accatcccaa agccaacgaa gtgccagaac ccaaatccaa gcttggctgt   2460

ctcatcccca aggacgtact ctttatgccg ttccttatga cttttcatgc agcaggtgca   2520

aggcagcaag aatttggctc ttctgacatt tatcaggcac ctggtatgtg ccaggcctac   2580

tgtaaacccc aagatgacat ggtccatgtc tatccattca gcatcagaga gactgttatc   2640

aggacttgag gcctgagaca cagccctgaa tcagatgcag gcctctggtg tttgcaaagg   2700

atgcgtgagt atgtgtatgt gtatgcgtgc attgtgtgta ggggtgtgtg tatgttgggg   2760

gttgggggca gaaaatgctc cctgaactgt tggtattaag gcagatcttt gatggaggga   2820

ctggggtgtg gagacttgaa ccctagtttc aaagtgggga cctcgaacac tagtatggcc   2880

agcagacagg ctggagttgc tgaattgtca gctaggtctt taatccactc cccttctcta   2940

aatcagggtg gaattggact cagggctggt tcagggctga ggtttccggg ggatgaatga   3000

ttccagacag tgggaagggg tgatggatga tgaacctggc aagtcacagg actatggact   3060

tggctgtatg ttgcatgtat gtgtaagatc tgagttgaga cctttgattt ttgcccagaa   3120

agtccagcta acatactata taagccagtg agaccagcca gtgtctgttc attgcctctg   3180

ccttgcccct atgcctgccc gcctcctata gcaggtccct atagcataat gaaaatgcga   3240

acaacctttt ctctggacac tggggaatct agtctggtgg ataaagatgg atggctgtta   3300

aacgatc                                                             3307


<210>  984
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  984

Met Glu His Leu Leu Cys Ala Tyr Ile Ser Tyr Ala Leu Ser Leu Ile 
1               5                   10                  15


Ile Lys Arg Arg Leu Glu Ala Arg His Lys Ser Tyr Leu His Ser Arg 
            20                  25                  30


Arg Gly Asp His Ala Lys Asp Lys Leu Gln Arg Asp Asn Arg Phe Thr 
        35                  40                  45


Ser Gln Thr His Ser His Trp Ala Lys Ser Ser Cys His Cys Arg Phe 
    50                  55                  60


Glu Ser Arg Pro Phe Phe Leu Pro Ser Pro Ser Trp Ser Tyr Asn Arg 
65                  70                  75                  80


Ser Trp Gly Gly Glu Ser Ala Glu Arg Thr Trp Met Lys Gln Arg Gly 
                85                  90                  95


Thr Cys Leu Ser His Ser Pro Leu Asp Leu Leu His Pro Gly Leu Cys 
            100                 105                 110


Gln His Lys Val Gly Ala Arg 
        115


<210>  985
<211>  2194
<212>  DNA
<213>  Homo sapiens

<400>  985
gtcaacagcc acttcctccc tggggcttaa caggcattcc ttgaagcctg ccccgggcag     60

ttagtccttc ccttttgtgt gaactctcgg ctgttttcgt tgtctgcaca cagagcagtg    120

gtctagggag cgaagggttt tggaatggac cttttccttt cttagcttgc tgtagggatt    180

gtgcttcagc taagtaaagt ggaaaaacag aagtacaaaa gcaacagccc cagatctaag    240

ggcaccgtag ctctggaatc tggattttat tccagattca accctcagca gggagttgaa    300

gtggtcagcc ctgtgcttta caaggctgat tgggcagcac ccatagtaga attgtcaata    360

taaagtaatt gaaaggatca gaatccaggg ttttcgttgt ttttaagttt ttaagtttta    420

aaaacaaagt tgtttttgtt cgtttttaag tttacttctc tttaatcggt ctcactttat    480

tgaccaggct ggtttcgaac tcctgggctt aagtgatttc tcctgtctca gcttctcaaa    540

gtgctgggat tacaggcgtg agccgctgca cccagcccag aatccagttt taaagagttt    600

attcaagcca aaagctggga atggccatct gagaaacaca gactctagga aaatggggcc    660

agggccctga agttaaaagt taaagtcttg cttacatagg cagaaagcaa agacatttag    720

taaccttgta gaacattttc ttgtataact tttcttgttt taactttctt gtttaacatt    780

ttctatgcaa ggctggttta tgagttacaa cctataatta attataggtt gttcccctgc    840

ctccaccttg ttttcttttc tctacagctt gttttcattt cctttccaat ttaagaatgt    900

gtttaacatt ctatcccaga caatgtgatg gtcatgaagt ctctgtcaga gaggaaagag    960

ggagttaatc tataatgaag atcaacagtg aagaggaaag gggtcttccc tggaacgctt   1020

cagtcatata cgacatttta cacaacaata atggacctgt gtaaggaggt atgtgtggga   1080

gaagattcca gaaggtcttg agacactcca gatgaaggtt ggtgtggggc tgtgctgctg   1140

gagcaccaga gagtgaaaag aggttatctc cctctgtgcc aggccagagt gcagtggtgc   1200

aatcacggct cactgtagtc tcaacctcct gggctcaaga gatcctccca cttcagcctc   1260

ccaagcagct aagactacag acatgtcctt aaccttggca caacaaatct ctaaatcgat   1320

tgagacctgt ctcagatact tcttggttta caagatggag gctgaaatta aagagaaaga   1380

tcctcactca actcacagag gagcagaatg ggaagaggac ttagtgagaa ttccctgaac   1440

acaggagaaa accgaagccc agagagtgga tggccaagtc caaggtcaca cagccaagtg   1500

catccgagca gcgcaggatc caggtttcct gccccagtgc tctttctgca gcccatgcca   1560

cctgttttca tgctatctca gttcaccttc cagctacaca cctgcaatca gaaacagaaa   1620

gtctgagagt gtgtgtggag ccaaagaggg gacagcagtg gttagaagca aggcacaagt   1680

catacctaca ttcaaggaga ggggaccatg caaaggataa actgcagaga gacaacagat   1740

ttacatccca gacacattca cactgggcca agagcagctg ccattgcaga ttcgagtcac   1800

gtcctttttt ccttccttct ccttcttgga gttacaacag aagctgggga ggtgagagtg   1860

cagaaaggac gtggatgaag cagagaggca cgtgcctgtc tcattcgcct ctggatctgc   1920

tgcatccagg actgtgccag cacaaagtgg gagcccgata aatatttatt gaagaaatga   1980

aaggtgacaa aaggcagaag gagggagacc ccaaaaagag cagcacagga agctgccccc   2040

tcaaacacta aaggctcctg gagctattca cagtgctggg gaacaaccag aggaggagga   2100

ggacagaggg agagaatact ttttttaaaa atcccaaaca aaaccaaatt ctatacatgt   2160

atatctcgag tgagtaaatg tgtaacactc agca                               2194


<210>  986
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  986

Met Ala Lys Ser Lys Val Thr Gln Pro Ser Ala Ser Glu Gln Arg Arg 
1               5                   10                  15


Ile Gln Val Ser Cys Pro Ser Ala Leu Ser Ala Ala His Ala Thr Cys 
            20                  25                  30


Phe His Ala Ile Ser Val His Leu Pro Ala Thr His Leu Gln Ser Glu 
        35                  40                  45


Thr Glu Ser Leu Arg Val Cys Val Glu Pro Lys Arg Gly Gln Gln Trp 
    50                  55                  60


Leu Glu Ala Arg His Lys Ser Tyr Leu His Ser Arg Arg Gly Asp His 
65                  70                  75                  80


Ala Lys Asp Lys Leu Gln Arg Asp Asn Arg Phe Thr Ser Gln Thr His 
                85                  90                  95


Ser His Trp Ala Lys Ser Ser Cys His Cys Arg Phe Glu Ser Arg Pro 
            100                 105                 110


Phe Phe Leu Pro Ser Pro Ser Trp Ser Tyr Asn Arg Ser Trp Gly Gly 
        115                 120                 125


Glu Ser Ala Glu Arg Thr Trp Met Lys Gln Arg Gly Thr Cys Leu Ser 
    130                 135                 140


His Ser Pro Leu Asp Leu Leu His Pro Gly Leu Cys Gln His Lys Val 
145                 150                 155                 160


Gly Ala Arg 



<210>  987
<211>  1161
<212>  DNA
<213>  Homo sapiens

<400>  987
acacgtgtga gcctagaggc gggtcccggt tgcagacttg ccatggcctc cgaagcttct     60

gtgcgtctag gggtgccccc tggccgtctg tggatccaga ggcctggcat ctacgaagat    120

gaggagggga gaacctgggt gactgtggtc gtgcggttca atccctcgcg tagggaatgg    180

gccagggcct cccagggcag cagatatgaa cccagcatca cagtgcactt gtggcagatg    240

gcagtgcata cccgggagct actctcctcc ggccagatgc ccttctccca gctgcccgcc    300

gtgtggcagc tctaccccgg gaggaagtac cgagcagcgg attccagttt ctgggaaata    360

gcagaccatg gccagattga ctctatggag cagctggtcc taacatatca gccggagagg    420

aaagactgac actgggagtg gctggccctg ctggccctgc ctcttctggc ctggtgtctc    480

ctcatgcccc ctcagtgagg atcttcatgt acctgctctt ctgtttgcac acccagcata    540

gcctccttgc aggcagaagg cagtagggcc cctgcacact cagtttctct cgttttcctt    600

agttatcagt cctgtcctgt cccactcagg tctgtactta gggcagctgg cctggatggg    660

cttcactggg gccctgtctg tgtgctgagc cagtttcccc tgctggctgc aagctgtggg    720

ttctttctcc tctgtgcccc tcatgctgat cttctagatg ccactcccaa atccccttca    780

tacccaccag gatgtgtgcc cagccaggcc tccagcaccc ccagtgcagc tcgtgattgg    840

aaactcacca tcggcaggca gtggttcggt ttaagagatg gcattagagg gagcccagtc    900

tggatgtgga cttggatgcc ctgtgggtat cagttctgct gacactttgg cccgaaatag    960

atccagtgct gagcaagcaa tgtacaccag agcctcagtg agcccatctg cacagtgggg   1020

agcatggagg gatgggtttg gcctgtgctt ctgcttattc agtccttcag ctcacggaag   1080

ggatgctagt ccgtgaaggt gacctcacag tactggttaa ttaaacttta ttgctcactg   1140

tccaaaaaaa aaaaaaaaaa a                                             1161


<210>  988
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  988

Met Ala Ser Glu Ala Ser Val Arg Leu Gly Val Pro Pro Gly Arg Leu 
1               5                   10                  15


Trp Ile Gln Arg Pro Gly Ile Tyr Glu Asp Glu Glu Gly Arg Thr Trp 
            20                  25                  30


Val Thr Val Val Val Arg Phe Asn Pro Ser Arg Arg Glu Trp Ala Arg 
        35                  40                  45


Ala Ser Gln Gly Ser Arg Tyr Glu Pro Ser Ile Thr Val His Leu Trp 
    50                  55                  60


Gln Met Ala Val His Thr Arg Glu Leu Leu Ser Ser Gly Gln Met Pro 
65                  70                  75                  80


Phe Ser Gln Leu Pro Ala Val Trp Gln Leu Tyr Pro Gly Arg Lys Tyr 
                85                  90                  95


Arg Ala Ala Asp Ser Ser Phe Trp Glu Ile Ala Asp His Gly Gln Ile 
            100                 105                 110


Asp Ser Met Glu Gln Leu Val Leu Thr Tyr Gln Pro Glu Arg Lys Asp 
        115                 120                 125


<210>  989
<211>  1754
<212>  DNA
<213>  Homo sapiens

<400>  989
acacgtgtga gcctagaggc gggtcccggt tgcagacttg ccatggcctc cgaagcttct     60

gtgcgtctag gggtgccccc tggccgtctg tggatccaga ggcctggcat ctacgaagat    120

gaggagggga gaacctgggt gactgtggtc gtgcggttca atccctcgcg tagggaatgg    180

gccagggcct cccagggcag cagatatgaa cccagcatca cagtgcactt gtggcagatg    240

gcagtgcata cccgggagct actctcctcc ggccagatgc ccttctccca gctgcccgcc    300

gtgtggcagc tctaccccgg gaggaagtac cgagcagcgg attccagttt ctgggaaata    360

gcagaccatg gccagattga ctctatggag cagctggtcc taacatatca gccggagagg    420

aaagactgac actgggagtg gctggtatgt tggggccctg tgcgtctcgg tgtagggatc    480

agacgaaagt gagaagacct ctcctctttt cagaaagacg gcgtggcctc ctcctccctg    540

ctgtttgctg agatttttct tacatagcca cctgtcacct ctgttcccca gccccttgga    600

tgtgatggta cacagtgggt gggcccccat aataagttcc taaagcatgg gatctcatcg    660

aataagactc atcatttaat ccttgtgaga attttgtgag gtgtacgtgt taatgtccca    720

tttcacgacg aaaagacaag actctgggga tgggaatgac ttcctcgaga ccatacagcc    780

aggaaatagc ggtgaatcta gtgatctcgg gtccctagat ttaaccatgg cactgaggtg    840

ccgtgtgacg gtggccttgg aggacccagc actgacccat agagggctcc tctcagatgg    900

gcagcagctt ggagcaggca ggcagggcct ggtccattgg aggggctggc actggacttg    960

cctttgaccc cagcagcttg gatggggtgc cgggctcccc catagttcac tgactgtctc   1020

ctttggtctt ctcgcaggcc ctgctggccc tgcctcttct ggcctggtgt ctcctcatgc   1080

cccctcagtg aggatcttca tgtacctgct cttctgtttg cacacccagc atagcctcct   1140

tgcaggcaga aggcagtagg gcccctgcac actcagtttc tctcgttttc cttagttatc   1200

agtcctgtcc tgtcccactc aggtctgtac ttagggcagc tggcctggat gggcttcact   1260

ggggccctgt ctgtgtgctg agccagtttc ccctgctggc tgcaagctgt gggttctttc   1320

tcctctgtgc ccctcatgct gatcttctag atgccactcc caaatcccct tcatacccac   1380

caggatgtgt gcccagccag gcctccagca cccccagtgc agctcgtgat tggaaactca   1440

ccatcggcag gcagtggttc ggtttaagag atggcattag agggagccca gtctggatgt   1500

ggacttggat gccctgtggg tatcagttct gctgacactt tggcccgaaa tagatccagt   1560

gctgagcaag caatgtacac cagagcctca gtgagcccat ctgcacagtg gggagcatgg   1620

agggatgggt ttggcctgtg cttctgctta ttcagtcctt cagctcacgg aagggatgct   1680

agtccgtgaa ggtgacctca cagtactggt taattaaact ttattgctca ctgtccaaaa   1740

aaaaaaaaaa aaaa                                                     1754


<210>  990
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  990

Met Ala Ser Glu Ala Ser Val Arg Leu Gly Val Pro Pro Gly Arg Leu 
1               5                   10                  15


Trp Ile Gln Arg Pro Gly Ile Tyr Glu Asp Glu Glu Gly Arg Thr Trp 
            20                  25                  30


Val Thr Val Val Val Arg Phe Asn Pro Ser Arg Arg Glu Trp Ala Arg 
        35                  40                  45


Ala Ser Gln Gly Ser Arg Tyr Glu Pro Ser Ile Thr Val His Leu Trp 
    50                  55                  60


Gln Met Ala Val His Thr Arg Glu Leu Leu Ser Ser Gly Gln Met Pro 
65                  70                  75                  80


Phe Ser Gln Leu Pro Ala Val Trp Gln Leu Tyr Pro Gly Arg Lys Tyr 
                85                  90                  95


Arg Ala Ala Asp Ser Ser Phe Trp Glu Ile Ala Asp His Gly Gln Ile 
            100                 105                 110


Asp Ser Met Glu Gln Leu Val Leu Thr Tyr Gln Pro Glu Arg Lys Asp 
        115                 120                 125


<210>  991
<211>  1410
<212>  DNA
<213>  Homo sapiens

<400>  991
gtcctcccgc cccgccgctt ggtggcggcc gcatgctgcc cggatataaa gggtcggccc     60

cacatcccag ggaccagcga gcggccttga gaggctctgg ctcttgcttc ttaggcggcc    120

cgaggacgcc atggccgagt gcccgacact cggggaggca gtcaccgacc acccggaccg    180

cctgtgggcc tgggagaagt tcgtgtattt ggacgagaag cagcacgcct ggctgccctt    240

aaccatcgag ataaaggata ggttacagtt acgggtgctc ttgcgtcggg aagacgtcgt    300

cctggggagg cctatgaccc ccacccagat aggcccaagc ctgctgccta tcatgtggca    360

gctctaccct gatggacgat accgatcctc agactccagt ttctggcgct tagtgtacca    420

catcaagatt gacggcgtgg aggacatgct tctcgagctg ctgccagatg actgatgtat    480

ggtcttggca gcacctgtct cctttcaccc cagggcctga gcctggccag cctacaatgg    540

ggatgttgtg tttctgttca ccttcgttta ctatgcctgt gtcttctcca ccacgctggg    600

gtctgggagg aatggacaga cagaggatga gctctaccca gggcctgcag gacctgcctg    660

tagcccactc tgctcgcctt agcactacca ctcctgccaa ggaggattcc atttggcaga    720

gcttcttcca ggtgcccagc tatacctgtg cctcggcttt tctcagctgg atgatggtct    780

tcagcctctt tctgtccctt ctgtccctca cagcactagt atttcatgtt gcacacccac    840

tcagctccgt gaacttgtga gaacacagcc gattcacctg agcaggacct ctgaaaccct    900

ggaccagtgg tctcacatgg tgctacgcct gcatgtaaac acgcctgcaa acgctgcctg    960

ccggtaaaca cgcctgcaaa cgctgcctgc ccgtaaacac gcctgcaaac gctgcctgcc   1020

cacacaggtt cacgtgcagc tcaaggaaag gcctgaaagg agcccttatc tgtgctcagg   1080

actcagaagc ctctgggtca gtggtccaca tcccgggacg cagcaggagg ccaggccggc   1140

gagccctgtg gatgagccct cagaaccctt ggcttgccca cgtggaaaag ggatagaggt   1200

tgggtttccc cccttttata gatggtcacg cacctgggtg ttacaaagtt gtatgtggca   1260

tgaatacttt ttgtaatgat tgattaaatg caagatagtt tatctaactt cgtgcggaat   1320

cagcttctat ccttgactta gattctggtg gagagaagtg agaataggca gcccccaaat   1380

aaaaaatatt catggaaaaa aaaaaaaaaa                                    1410


<210>  992
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  992

Met Ala Glu Cys Pro Thr Leu Gly Glu Ala Val Thr Asp His Pro Asp 
1               5                   10                  15


Arg Leu Trp Ala Trp Glu Lys Phe Val Tyr Leu Asp Glu Lys Gln His 
            20                  25                  30


Ala Trp Leu Pro Leu Thr Ile Glu Ile Lys Asp Arg Leu Gln Leu Arg 
        35                  40                  45


Val Leu Leu Arg Arg Glu Asp Val Val Leu Gly Arg Pro Met Thr Pro 
    50                  55                  60


Thr Gln Ile Gly Pro Ser Leu Leu Pro Ile Met Trp Gln Leu Tyr Pro 
65                  70                  75                  80


Asp Gly Arg Tyr Arg Ser Ser Asp Ser Ser Phe Trp Arg Leu Val Tyr 
                85                  90                  95


His Ile Lys Ile Asp Gly Val Glu Asp Met Leu Leu Glu Leu Leu Pro 
            100                 105                 110


Asp Asp 



<210>  993
<211>  1847
<212>  DNA
<213>  Homo sapiens

<400>  993
cagctttgcg atccagcaga gagggctgga gacgggacga aggccacaac agacccggcc     60

ctgccagcgg gcggtggcgc ctccagatca gagccctcgg gaaggaggcc tgggcgggcc    120

tggcccgttc acctgtgtgc cctgcagttc tgcccgaggc tcaactctca agggcctggg    180

aggggtgctg ccggccaaga gggtccagga cctcactgga ctgtgcccca cagggagatc    240

ccgaagagcc tgtttctgtc cctcggggag ccaggaggga accaggacca tgttccagta    300

aatgaggact gcagcaggag ccgtgagccc tgactcccgg ccagagacac gacgtcagac    360

cagaaagaat gaggaggccg cgtggggccc gcgggtgtgc agggcagaga gggaggacaa    420

caggaagtgc cccccctcca tcctgaaacg gagccggccg gagcaccacc gcccagaggc    480

caagccccag aggacctcga ggcgcgtgtg gttccgagaa cccccagcgg tgaccgtcca    540

ctacattgct gacaagaacg ccacagccac tgtcagggtg cccggccggc ccaggccaca    600

cggcggctcc ctgctcctgc agctgtgtgt gtgcgtcctg ctcgtgctgg ccctgggcct    660

atactgcggc cgggccaagc ccgtggcaac ggcactggag gacctgcggg cccggctcct    720

cggccttgtc ctgcacctgc ggcacgtggc cctcacctgc tggcgcggcc tcctgcggct    780

ctgacgggca ggacgggcag gacgggcagg gcttccagga gagctcaagc actccggggg    840

ctccgagaca gcctgagccc tggccctgct gcttggtgaa tcatgggggc caaaaggggc    900

tgctgcctga gggctaacta ggaaaagggg gaccccgtgg cgtgagatcg gacatggggg    960

gcacagcggg cggccccgcc acactagtca gcacagccct cctgtctcct gtgttgggtc   1020

catgtgagat tttattagaa agaggattcg actgctaaca gttgaggctc cccaggctca   1080

cccaaagacc cctccctcgt cccagcagga actcctgctg ctgctagggc ctggcccggc   1140

catcaccgtg tgcaccctct tgaggagggg gacacactgc ccgtgttcaa ggggctgctc   1200

ggaggaggca aacccagcct tttgcgatta tggcttgtgg ggaatccaga cctcgaaacc   1260

ccacggggag ggaagggtct ggttgtcaag gtgggtccct ttgatgtgag gtgccatcct   1320

ctgagcccag gtctgacccc cctacccagc cccgtgagtc tggagaggcc ccagggaagg   1380

acccctcatc aggggcggct tcaggtgtag aagccgaggg gacagcaagg ggcccagaca   1440

cccccgacct tcagaacagc catctgtgcc cagctctgca ggccaggcac acccagctga   1500

gcccggggcc agccagcacc acccaccagc tggggcctgt gggtcccgga gaccgtctgt   1560

ggttgtggct ttgtcgccgg attgcagagc tgaagggagc cctgtggatg acaaacacca   1620

ggggcctctc cagaccctac gtggggggag ggctgaacaa agcagggagg cccacggtta   1680

gacaccaggc agaactgccc aggagagaca cagggacaat cagaccagcg tcctcgaggt   1740

tagcctgagg cgggtgggca cggccgacca tccacccggt ggttcctgtt tgtcccacca   1800

cttaactggg agacactgtt ttattaaaac acaccgtggc ttccttc                 1847


<210>  994
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  994

Met Arg Thr Ala Ala Gly Ala Val Ser Pro Asp Ser Arg Pro Glu Thr 
1               5                   10                  15


Arg Arg Gln Thr Arg Lys Asn Glu Glu Ala Ala Trp Gly Pro Arg Val 
            20                  25                  30


Cys Arg Ala Glu Arg Glu Asp Asn Arg Lys Cys Pro Pro Ser Ile Leu 
        35                  40                  45


Lys Arg Ser Arg Pro Glu His His Arg Pro Glu Ala Lys Pro Gln Arg 
    50                  55                  60


Thr Ser Arg Arg Val Trp Phe Arg Glu Pro Pro Ala Val Thr Val His 
65                  70                  75                  80


Tyr Ile Ala Asp Lys Asn Ala Thr Ala Thr Val Arg Val Pro Gly Arg 
                85                  90                  95


Pro Arg Pro His Gly Gly Ser Leu Leu Leu Gln Leu Cys Val Cys Val 
            100                 105                 110


Leu Leu Val Leu Ala Leu Gly Leu Tyr Cys Gly Arg Ala Lys Pro Val 
        115                 120                 125


Ala Thr Ala Leu Glu Asp Leu Arg Ala Arg Leu Leu Gly Leu Val Leu 
    130                 135                 140


His Leu Arg His Val Ala Leu Thr Cys Trp Arg Gly Leu Leu Arg Leu 
145                 150                 155                 160


<210>  995
<211>  2200
<212>  DNA
<213>  Homo sapiens

<400>  995
tgtaagctta aggatcttta ctttcagttt agccagagtg gaattagaac agggatatca     60

ttaacagcca gccaggacag aagcgaaggc gtctcagaag caacttggtg gaccagcctc    120

aggaaccccg ggtcatgcct gcacttccca ccttcctgcc tggggagagg cccaatcccc    180

tgagggaccc tggagagccc acgaccaggg ccgccagccc ctgcccagca cactgcaggc    240

ccagctgccc cttcccaggg cgatgtgtct gggctccgga gacagcccag tccagggtgg    300

gtctatgtct gcatgcagcc gaggatttcc atcaccctgg ccatggggct gttccacacc    360

tgctcctggg atccagcagt gcagccccca agaacagacc caaccggggc caagcctcag    420

gttccagaag ccacccctgc ctcctgcccc tccttcaggg ccctagatgg ctgtggcctg    480

gatcagggct gggcagaggg tgaggcagga gccaccccac cttctgctgg ggacacagac    540

aaggagctct ccggactgga aagagtcccc atgtccagtg ggtcagggct ggaaggggag    600

acaggggacc ccatcagctt agggggcctc ggattctgtc caaacccctt ccctcgagga    660

cctggctgcc agctggaaac tcagctggtc cccaaggcca gagccccctt gagcttccag    720

agcctcgatc cccctggact tgacaccccc gatgggcacc tgccagcctc actcccggga    780

cccaggatga tgcccccacc aggaccctcc atgtggaccc aggcacgtgg cctccaggag    840

gctggtgccc agccacccag agacacaagc cagctgctga tggtggacag ggtgggtcat    900

gaactcaggg agccaggggc tcgcctctcc ccgggaaggt gggcgcagca gcagggagca    960

cttggcagca ctcgagccaa gaaacggaca gcccctcatc gagccccggg tggggaggcc   1020

ccccgcctcc gcccccgccc cagaacgagt cctctggagg tggaccctgg gctttcctga   1080

ggggcagggt ccacagccaa gcagccccct acgccggggt cccaggttca catcccagct   1140

cctccacttg cttctgcggg gcctcagcac acagactctg cagaatggga aggcagctcc   1200

ctcctctctc aggtggatgc tgggcgtggg agcccatggg aggggcagag gggctgtcca   1260

cacagcaccc acggctccca tcacgcacac aatgctcaca cgcacaggcg tgcacatgct   1320

cacatgcaac acacgcacat tcacatgcac ttacgcacat gctgcacaca ctgcagacac   1380

acctgcctag acactcacac ctacacactc ttcctcacac tcacatgcat gcacactcat   1440

gtcacaggga gtcacaccct cacactcaca tcctcccagg cacactcaca atcaagcctt   1500

cacacgcaca acagtcacac cctcacatgc agtcacaccc acatgcacac tcatgcacaa   1560

tcacatcctc ccaggcagtc actcgcacat gcagtcacac attcactcac aggcagtcac   1620

actctcatgc actcagtcac accctcacat gcacactcat gcacactcat atcctcccat   1680

gcagtcacac actctcacat gcagtcacac cctctcgtgc acactcagtg acaccttcac   1740

atgcagtcac acctgcactg tcacacccac acatgcacac tcagtcacat cctctcatgc   1800

actcatatac acaatcacac cctcccatgc acaaaggcac tcacaatcac atcctcccat   1860

actcacccac acacagaccc ctgccatggc tcctggccca gtcctctatg tggtacgtgt   1920

gcccccgaaa tccccaacca gatgatgccc ccgattctgt ggagcccaga ttaccacttc   1980

cctgaccctc agccaagcac agacaggacc cacacacagt gaggtgaact cacaggcctc   2040

agaagcctcc ctgagcccgg ccacagggtc tcccaggcct atggcaccca cccaggaggg   2100

ggactcagct ggggaggggg ccaacctggg gccagaggct ggaaggtgcc gtgagctcct   2160

ccccacacgc agcctctgcc tggatggcag aattcatgca                         2200


<210>  996
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  996

Met Gln Pro Arg Ile Ser Ile Thr Leu Ala Met Gly Leu Phe His Thr 
1               5                   10                  15


Cys Ser Trp Asp Pro Ala Val Gln Pro Pro Arg Thr Asp Pro Thr Gly 
            20                  25                  30


Ala Lys Pro Gln Val Pro Glu Ala Thr Pro Ala Ser Cys Pro Ser Phe 
        35                  40                  45


Arg Ala Leu Asp Gly Cys Gly Leu Asp Gln Gly Trp Ala Glu Gly Glu 
    50                  55                  60


Ala Gly Ala Thr Pro Pro Ser Ala Gly Asp Thr Asp Lys Glu Leu Ser 
65                  70                  75                  80


Gly Leu Glu Arg Val Pro Met Ser Ser Gly Ser Gly Leu Glu Gly Glu 
                85                  90                  95


Thr Gly Asp Pro Ile Ser Leu Gly Gly Leu Gly Phe Cys Pro Asn Pro 
            100                 105                 110


Phe Pro Arg Gly Pro Gly Cys Gln Leu Glu Thr Gln Leu Val Pro Lys 
        115                 120                 125


Ala Arg Ala Pro Leu Ser Phe Gln Ser Leu Asp Pro Pro Gly Leu Asp 
    130                 135                 140


Thr Pro Asp Gly His Leu Pro Ala Ser Leu Pro Gly Pro Arg Met Met 
145                 150                 155                 160


Pro Pro Pro Gly Pro Ser Met Trp Thr Gln Ala Arg Gly Leu Gln Glu 
                165                 170                 175


Ala Gly Ala Gln Pro Pro Arg Asp Thr Ser Gln Leu Leu Met Val Asp 
            180                 185                 190


Arg Val Gly His Glu Leu Arg Glu Pro Gly Ala Arg Leu Ser Pro Gly 
        195                 200                 205


Arg Trp Ala Gln Gln Gln Gly Ala Leu Gly Ser Thr Arg Ala Lys Lys 
    210                 215                 220


Arg Thr Ala Pro His Arg Ala Pro Gly Gly Glu Ala Pro Arg Leu Arg 
225                 230                 235                 240


Pro Arg Pro Arg Thr Ser Pro Leu Glu Val Asp Pro Gly Leu Ser 
                245                 250                 255


<210>  997
<211>  1623
<212>  DNA
<213>  Homo sapiens

<400>  997
gctctcgccc gggccggcca tggcgctcaa caatttcctt ttcgctcagt gcgcctgcta     60

cttcttggcc ttcctgttca gcttcgtggt ggtggtcccg ctgtccgaga acggccacga    120

cttccgcggc cgctgcctgc tcttcaccga gggcatgtgg ctgagcgcca acctcacggt    180

gcaggagcgc gagcgcttca cggtgcagga gtggggcccg ccggccgcct gccgcttcag    240

cctgctcgcc agcctcctgt ctctgctgct ggccgccgcg cacgcctggc gcacgctctt    300

cttcctatgc aagggacacg agggctcctt cttctccgcc ttcctgaacc tcctggtcag    360

cgccttcgtg gtcttcctgg tcttcattgc cagcaccatc gtgagcgtgg gcttcaccat    420

gtggtgcgac accatcaccg agaagggcac cgtaccccac agctgtgaag agctccagga    480

catcgacttg gagctgggcg tggacaactc cgccttctac gatcagtttg caattgccca    540

ggtagggggc tctgggcaag aagggaggct tgcaatgctg ggagggggcc atttactgct    600

ggacatttgc tgagctctcc cccatccaga ggaggaggca ggctcctgtg tggataaggt    660

agttagcaat gggaccaggc agtgggagca gtcgggaagg cttcctgcag gaggtggggg    720

agagctgggc ttttgtaggt gggtttgggg aggagatggc cacagtgagt tagaatcagg    780

aagtggcaag gccctggggt ctggggtggg aagtgtgggg gtgtgggggg aggtggtgcc    840

agaaacgaaa ccaggcatca gatcctgggg gtccagtgta gggacaaggg ctttggactt    900

tggtgctggc gctgggtggg cctgttcaga tcagagctgg aggcttagag gagtccccta    960

gccaggggga agctgataca gagtccaagg aaggaggcag gggatcccac ttgtgaattc   1020

agatttgcca ccctgccctt gtataagctg cgtcccccgc cccctaggag acttggtgga   1080

gggcgatggt ggcccccact ctgagggacg ctatttgctg aaatgcaggc atgtggggac   1140

acatcagtgg cccgtgaggg ccggaggggg aaccctggaa ttgggtttgc cccttgaaat   1200

ctgcagatgt gccccagacg gagatgaggc agatgagggg tgccgggtgg gggtggctga   1260

gaccagacac ctggctcctg ccagcactga tcagggcccg ctggcttcag gtccaattcc   1320

ggaccccagg ctggcctctg aaggctcttg ctggccgtgg ctggcctgag gacgcttctc   1380

ctggccagga gccctccaag ggtgctggac gtgggtgggc ctgaatgctc tttgccgaga   1440

tgaactggac ctgtcaaaga caccttcatg caaatttagt gagtggaaga ggcctcaggc   1500

ctaatttgtg ccagttggat taaggtgtga gtgcagtctg atggcaaata cgctcaaatg   1560

agaatcagct taatgtagct caggcctggt tctgattaaa ttgtttctcc ttcaactgtt   1620

tgg                                                                 1623


<210>  998
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  998

Met Ala Leu Asn Asn Phe Leu Phe Ala Gln Cys Ala Cys Tyr Phe Leu 
1               5                   10                  15


Ala Phe Leu Phe Ser Phe Val Val Val Val Pro Leu Ser Glu Asn Gly 
            20                  25                  30


His Asp Phe Arg Gly Arg Cys Leu Leu Phe Thr Glu Gly Met Trp Leu 
        35                  40                  45


Ser Ala Asn Leu Thr Val Gln Glu Arg Glu Arg Phe Thr Val Gln Glu 
    50                  55                  60


Trp Gly Pro Pro Ala Ala Cys Arg Phe Ser Leu Leu Ala Ser Leu Leu 
65                  70                  75                  80


Ser Leu Leu Leu Ala Ala Ala His Ala Trp Arg Thr Leu Phe Phe Leu 
                85                  90                  95


Cys Lys Gly His Glu Gly Ser Phe Phe Ser Ala Phe Leu Asn Leu Leu 
            100                 105                 110


Val Ser Ala Phe Val Val Phe Leu Val Phe Ile Ala Ser Thr Ile Val 
        115                 120                 125


Ser Val Gly Phe Thr Met Trp Cys Asp Thr Ile Thr Glu Lys Gly Thr 
    130                 135                 140


Val Pro His Ser Cys Glu Glu Leu Gln Asp Ile Asp Leu Glu Leu Gly 
145                 150                 155                 160


Val Asp Asn Ser Ala Phe Tyr Asp Gln Phe Ala Ile Ala Gln Val Gly 
                165                 170                 175


Gly Ser Gly Gln Glu Gly Arg Leu Ala Met Leu Gly Gly Gly His Leu 
            180                 185                 190


Leu Leu Asp Ile Cys 
        195


<210>  999
<211>  4668
<212>  DNA
<213>  Homo sapiens

<400>  999
cgccccgcgc ccgccaggag ccaccgtccg agccttgcgg agcgcggcag tgggcgccgg     60

ctgcccgcag cccctgaccc ggccccggac ggagcgccgg ccgcaccacc gccctctggc    120

cgttgcctca ccggctcggc aagatgtcgg tgaaggaggg cgcacagcgc aagtgggcag    180

cgctgaagga gaagctgggg ccacaggatt cggaccccac ggaggccaac ctggagagcg    240

cggaccccga gctgtgcatc cggctgctcc agatgccctc tgtggtcaac tactccggcc    300

tgcgcaagcg cctggagggc agcgacggcg gctggatggt gcagttcctg gagcagagcg    360

gcctggacct gctgctggag gcgctggcgc ggctgtcggg ccgcggcgtt gcacgtatct    420

ccgacgccct gctgcagctc acctgcgtca gctgcgtgcg cgccgtcatg aactcgcggc    480

agggcatcga gtacatcctc agcaaccagg gctacgtgcg ccagctctcc caggccctgg    540

acacatccaa cgtgatggtg aagaagcagg tgtttgagct actggctgcc ctgtgcatct    600

actctcccga gggccacgtg ctgaccctgg acgccctgga ccactacaag acggtgtgca    660

gccagcagta ccgcttcagc attgtcatga acgagctctc cggcagcgac aacgtgccct    720

acgtggtcac cctgcttagc gtgatcaacg ccgtcatctt gggccccgag gacctgcgcg    780

cgcgcaccca gctgcggaac gagtttatcg ggctgcagct gctggacgtc ctggctcgcc    840

tgcgagacct ggaggatgcc gacctgctga tccagctgga ggctttcgag gaggctaagg    900

ccgaggacga ggaggagctg ctgcgagtct ctggcggggt cgacatgagc agccaccagg    960

aggtctttgc ctccctgttc cacaaggtga gctgctcccc ggtgtctgcc cagctcctgt   1020

cggtgctgca gggcctcctg cacctggagc ccaccctccg ctccagccag ctgctctggg   1080

aggccctgga gagcctcgtg aaccgggccg tgctcctggc cagcgatgcc caggaatgca   1140

ccctggagga agtggttgag cggctcctgt ctgtcaaggg gcgacccaga ccgagccccc   1200

tggtcaaggc ccataaaagc gtccaggcca acctagacca gagccagagg ggcagctccc   1260

cgcaaaacac tacaaccccc aagcccagcg tggagggcca gcagccagca gcagctgctg   1320

cctgcgagcc cgtggaccac gcccagagtg agagcatcct gaaagtttcg cagcccagag   1380

ccctggagca gcaggcgtcc accccacccc cacccccacc cccacccctg ctccctggtt   1440

ccagtgccga gccccctccc cctcccccac caccccccct gcccagtgtg ggggctaagg   1500

ccctcccaac agcacccccg cccccacccc tgccaggcct gggggccatg gcccccccag   1560

cacctcctct accaccaccc ctgccaggct cctgtgagtt cctgccccca ccacctccac   1620

cactcccggg cttgggatgc ccgcccccac ccccacccct gctgcctggt atgggctggg   1680

gccctcctcc acccccacct ccactactgc cctgcacctg cagccccccc gtggcgggag   1740

gcatggagga ggtcatcgtg gcccaggtgg accatggctt gggctcagca tgggtcccca   1800

gccatcggcg ggtgaaccca cccacactgc gcatgaagaa gctgaactgg cagaagctgc   1860

catccaacgt ggcacgtgag cacaactcta tgtgggcgtc cctgagcagc cccgacgccg   1920

aggctgtgga gcccgacttc tccagcatcg agcgactatt ctccttccct gcagccaagc   1980

ccaaggagcc caccatggtg gccccccggg ccaggaagga gcccaaggag atcactttcc   2040

tcgatgccaa gaagagcctg aacctcaaca tcttcctgaa gcaatttaag tgctccaacg   2100

aggaggtcgc tgctatgatc cgggctggag ataccaccaa gtttgatgtg gaggttctca   2160

aacaactcct taagctcctt cccgagaagc acgagattga aaacctgcgg gcattcacag   2220

aggagcgagc caagctggcc agcgccgacc acttctacct cctcctgctg gccattccct   2280

gctaccagct gcgaatcgag tgcatgctgc tgtgtgaggg cgcggccgcc gtgctggaca   2340

tggtgcggcc caaggcccag ctggtgctgg ctgcctgcga aagcctgctc accagccgcc   2400

agctgcccat cttctgccag ctgatcctga gaattgggaa cttcctcaac tacggcagcc   2460

acaccggtga cgccgacggc ttcaagatca gcacattgct gaagctcacg gagaccaagt   2520

cccagcagaa ccgcgtgacg ctgctgcacc acgtgctgga ggaagcggaa aagagccacc   2580

ccgacctcct gcagctgccc cgggacctgg aacagccctc gcaagcagca gggatcaacc   2640

tggagatcat ccgctcagag gccagctcca acctgaagaa gcttctggag accgagcgga   2700

aggtgtctgc ctccgtggcc gaggtccagg agcagtacac cgagcgcctc caggccagca   2760

tctcggcctt ccgggcactg gatgagctgt ttgaggccat cgagcagaag caacgggagc   2820

tggccgacta cctgtgtgag gacgcccagc agctgtccct ggaggacacg ttcagcacca   2880

tgaaggcttt ccgggacctt ttcctccgcg ccctgaagga gaacaaggac cggaaggagc   2940

aggcggcgaa ggcagagagg aggaagcagc agctggcgga ggaggaggcg cggcggcctc   3000

ggggagagga cgggaagcct gtcaggaagg ggcccgggaa gcaggaggag gtgtgtgtca   3060

tcgatgccct gctggctgac atcaggaagg gcttccagct gcggaagaca gcccggggcc   3120

gcggggacac cgacgggggc agcaaggcag cctccatgga tcccccaaga gccacagagc   3180

ctgtggccac cagtaaccct gcaggagatc ccgtgggcag cacgcgctgt cccgcctctg   3240

agcccggcct tgatgctaca acagccagcg agtcccgggg ctgggacctt gtagacgccg   3300

tgacccccgg ccctcagccc accctggagc agttggagga gggtggtcca cggcccctgg   3360

agaggcgttc ttcctggtat gtggatgcca gcgatgtcct aaccactgag gatccccagt   3420

gcccccagcc cttggagggg gcctggccgg tgactctggg agatgctcag gccctgaagc   3480

ccctcaagtt ctccagcaac cagccccctg cagccggaag ttcaaggcaa gatgccaagg   3540

atcccacgtc cttgctgggc gtcctccagg ccgaggccga cagcacaagt gaggggctgg   3600

aggacgctgt ccacagccgt ggtgccagac cccctgcagc aggcccaggt ggggatgagg   3660

acgaggacga ggaggacacg gccccagagt ccgcactgga cacatccctg gacaagtcct   3720

tctccgagga tgcggtgacc gactcctcgg ggtcgggcac actccccagg gcccggggcc   3780

gggcctcaaa ggggaccggg aagcgaagga agaagcgtcc ctccaggagc caggaaggcc   3840

tcaggcccag gcccaaggcc aagtgagaga gcccaggcca caggacatgc tgccattctg   3900

ccaagagagg ctcttctggg ggccaggctg ggactgggcc ccggaaacca aaactccgtg   3960

ccttacccag ccggggccct cctggagcct tcttggggtg ttgtggctgg gaacccgaca   4020

ggcaccagtg ccctgccagg cctggtgccc tcctggaccg cctgcacgtg ccagcctccc   4080

acctgcttcc taaaggcaac cctggcccac acccgcatgc gcccggtgca gcctgccaag   4140

ggccagtcgg ggggtgctgc gtcctgccag tgtccaccac agctctgcct gcccttcagc   4200

ccagcaaggt ttaatcaaaa tgcaatgctt tgcaagtctt tactgcttgg aggtggctga   4260

gttgggggcc ctgggcaggg gtaagctggc aggcagtgcc atggcaggcc agggtcccct   4320

cccatggggt ctggcccccg ttccagcatg tccagcccct gaagttggag tggggggcgg   4380

tctgcctttg ctgccactgc caggcctctg ccctgcagct gaaacttggc catcacatca   4440

acagaaaacc cctcccagtg ccagctgccc agcgtgggca ggccctgggg acaatacagg   4500

tccacctgag gggctgcagg gtgacaccca gcagccgctg ccccctcact gcccacccag   4560

cgagggcagc ctacccgagc ctgccccctg ccaggtgtgt gccctgaggc tggcggctgg   4620

atgcgtggcc aataaaaagc agacctagcc cggaaaaaaa aaaaaaaa                4668


<210>  1000
<211>  1240
<212>  PRT
<213>  Homo sapiens

<400>  1000

Met Ser Val Lys Glu Gly Ala Gln Arg Lys Trp Ala Ala Leu Lys Glu 
1               5                   10                  15


Lys Leu Gly Pro Gln Asp Ser Asp Pro Thr Glu Ala Asn Leu Glu Ser 
            20                  25                  30


Ala Asp Pro Glu Leu Cys Ile Arg Leu Leu Gln Met Pro Ser Val Val 
        35                  40                  45


Asn Tyr Ser Gly Leu Arg Lys Arg Leu Glu Gly Ser Asp Gly Gly Trp 
    50                  55                  60


Met Val Gln Phe Leu Glu Gln Ser Gly Leu Asp Leu Leu Leu Glu Ala 
65                  70                  75                  80


Leu Ala Arg Leu Ser Gly Arg Gly Val Ala Arg Ile Ser Asp Ala Leu 
                85                  90                  95


Leu Gln Leu Thr Cys Val Ser Cys Val Arg Ala Val Met Asn Ser Arg 
            100                 105                 110


Gln Gly Ile Glu Tyr Ile Leu Ser Asn Gln Gly Tyr Val Arg Gln Leu 
        115                 120                 125


Ser Gln Ala Leu Asp Thr Ser Asn Val Met Val Lys Lys Gln Val Phe 
    130                 135                 140


Glu Leu Leu Ala Ala Leu Cys Ile Tyr Ser Pro Glu Gly His Val Leu 
145                 150                 155                 160


Thr Leu Asp Ala Leu Asp His Tyr Lys Thr Val Cys Ser Gln Gln Tyr 
                165                 170                 175


Arg Phe Ser Ile Val Met Asn Glu Leu Ser Gly Ser Asp Asn Val Pro 
            180                 185                 190


Tyr Val Val Thr Leu Leu Ser Val Ile Asn Ala Val Ile Leu Gly Pro 
        195                 200                 205


Glu Asp Leu Arg Ala Arg Thr Gln Leu Arg Asn Glu Phe Ile Gly Leu 
    210                 215                 220


Gln Leu Leu Asp Val Leu Ala Arg Leu Arg Asp Leu Glu Asp Ala Asp 
225                 230                 235                 240


Leu Leu Ile Gln Leu Glu Ala Phe Glu Glu Ala Lys Ala Glu Asp Glu 
                245                 250                 255


Glu Glu Leu Leu Arg Val Ser Gly Gly Val Asp Met Ser Ser His Gln 
            260                 265                 270


Glu Val Phe Ala Ser Leu Phe His Lys Val Ser Cys Ser Pro Val Ser 
        275                 280                 285


Ala Gln Leu Leu Ser Val Leu Gln Gly Leu Leu His Leu Glu Pro Thr 
    290                 295                 300


Leu Arg Ser Ser Gln Leu Leu Trp Glu Ala Leu Glu Ser Leu Val Asn 
305                 310                 315                 320


Arg Ala Val Leu Leu Ala Ser Asp Ala Gln Glu Cys Thr Leu Glu Glu 
                325                 330                 335


Val Val Glu Arg Leu Leu Ser Val Lys Gly Arg Pro Arg Pro Ser Pro 
            340                 345                 350


Leu Val Lys Ala His Lys Ser Val Gln Ala Asn Leu Asp Gln Ser Gln 
        355                 360                 365


Arg Gly Ser Ser Pro Gln Asn Thr Thr Thr Pro Lys Pro Ser Val Glu 
    370                 375                 380


Gly Gln Gln Pro Ala Ala Ala Ala Ala Cys Glu Pro Val Asp His Ala 
385                 390                 395                 400


Gln Ser Glu Ser Ile Leu Lys Val Ser Gln Pro Arg Ala Leu Glu Gln 
                405                 410                 415


Gln Ala Ser Thr Pro Pro Pro Pro Pro Pro Pro Pro Leu Leu Pro Gly 
            420                 425                 430


Ser Ser Ala Glu Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Ser 
        435                 440                 445


Val Gly Ala Lys Ala Leu Pro Thr Ala Pro Pro Pro Pro Pro Leu Pro 
    450                 455                 460


Gly Leu Gly Ala Met Ala Pro Pro Ala Pro Pro Leu Pro Pro Pro Leu 
465                 470                 475                 480


Pro Gly Ser Cys Glu Phe Leu Pro Pro Pro Pro Pro Pro Leu Pro Gly 
                485                 490                 495


Leu Gly Cys Pro Pro Pro Pro Pro Pro Leu Leu Pro Gly Met Gly Trp 
            500                 505                 510


Gly Pro Pro Pro Pro Pro Pro Pro Leu Leu Pro Cys Thr Cys Ser Pro 
        515                 520                 525


Pro Val Ala Gly Gly Met Glu Glu Val Ile Val Ala Gln Val Asp His 
    530                 535                 540


Gly Leu Gly Ser Ala Trp Val Pro Ser His Arg Arg Val Asn Pro Pro 
545                 550                 555                 560


Thr Leu Arg Met Lys Lys Leu Asn Trp Gln Lys Leu Pro Ser Asn Val 
                565                 570                 575


Ala Arg Glu His Asn Ser Met Trp Ala Ser Leu Ser Ser Pro Asp Ala 
            580                 585                 590


Glu Ala Val Glu Pro Asp Phe Ser Ser Ile Glu Arg Leu Phe Ser Phe 
        595                 600                 605


Pro Ala Ala Lys Pro Lys Glu Pro Thr Met Val Ala Pro Arg Ala Arg 
    610                 615                 620


Lys Glu Pro Lys Glu Ile Thr Phe Leu Asp Ala Lys Lys Ser Leu Asn 
625                 630                 635                 640


Leu Asn Ile Phe Leu Lys Gln Phe Lys Cys Ser Asn Glu Glu Val Ala 
                645                 650                 655


Ala Met Ile Arg Ala Gly Asp Thr Thr Lys Phe Asp Val Glu Val Leu 
            660                 665                 670


Lys Gln Leu Leu Lys Leu Leu Pro Glu Lys His Glu Ile Glu Asn Leu 
        675                 680                 685


Arg Ala Phe Thr Glu Glu Arg Ala Lys Leu Ala Ser Ala Asp His Phe 
    690                 695                 700


Tyr Leu Leu Leu Leu Ala Ile Pro Cys Tyr Gln Leu Arg Ile Glu Cys 
705                 710                 715                 720


Met Leu Leu Cys Glu Gly Ala Ala Ala Val Leu Asp Met Val Arg Pro 
                725                 730                 735


Lys Ala Gln Leu Val Leu Ala Ala Cys Glu Ser Leu Leu Thr Ser Arg 
            740                 745                 750


Gln Leu Pro Ile Phe Cys Gln Leu Ile Leu Arg Ile Gly Asn Phe Leu 
        755                 760                 765


Asn Tyr Gly Ser His Thr Gly Asp Ala Asp Gly Phe Lys Ile Ser Thr 
    770                 775                 780


Leu Leu Lys Leu Thr Glu Thr Lys Ser Gln Gln Asn Arg Val Thr Leu 
785                 790                 795                 800


Leu His His Val Leu Glu Glu Ala Glu Lys Ser His Pro Asp Leu Leu 
                805                 810                 815


Gln Leu Pro Arg Asp Leu Glu Gln Pro Ser Gln Ala Ala Gly Ile Asn 
            820                 825                 830


Leu Glu Ile Ile Arg Ser Glu Ala Ser Ser Asn Leu Lys Lys Leu Leu 
        835                 840                 845


Glu Thr Glu Arg Lys Val Ser Ala Ser Val Ala Glu Val Gln Glu Gln 
    850                 855                 860


Tyr Thr Glu Arg Leu Gln Ala Ser Ile Ser Ala Phe Arg Ala Leu Asp 
865                 870                 875                 880


Glu Leu Phe Glu Ala Ile Glu Gln Lys Gln Arg Glu Leu Ala Asp Tyr 
                885                 890                 895


Leu Cys Glu Asp Ala Gln Gln Leu Ser Leu Glu Asp Thr Phe Ser Thr 
            900                 905                 910


Met Lys Ala Phe Arg Asp Leu Phe Leu Arg Ala Leu Lys Glu Asn Lys 
        915                 920                 925


Asp Arg Lys Glu Gln Ala Ala Lys Ala Glu Arg Arg Lys Gln Gln Leu 
    930                 935                 940


Ala Glu Glu Glu Ala Arg Arg Pro Arg Gly Glu Asp Gly Lys Pro Val 
945                 950                 955                 960


Arg Lys Gly Pro Gly Lys Gln Glu Glu Val Cys Val Ile Asp Ala Leu 
                965                 970                 975


Leu Ala Asp Ile Arg Lys Gly Phe Gln Leu Arg Lys Thr Ala Arg Gly 
            980                 985                 990


Arg Gly Asp Thr Asp Gly Gly Ser Lys Ala Ala Ser Met Asp Pro Pro 
        995                 1000                1005


Arg Ala Thr Glu Pro Val Ala Thr Ser Asn Pro Ala Gly Asp Pro Val 
    1010                1015                1020


Gly Ser Thr Arg Cys Pro Ala Ser Glu Pro Gly Leu Asp Ala Thr Thr 
1025                1030                1035                1040


Ala Ser Glu Ser Arg Gly Trp Asp Leu Val Asp Ala Val Thr Pro Gly 
                1045                1050                1055


Pro Gln Pro Thr Leu Glu Gln Leu Glu Glu Gly Gly Pro Arg Pro Leu 
            1060                1065                1070


Glu Arg Arg Ser Ser Trp Tyr Val Asp Ala Ser Asp Val Leu Thr Thr 
        1075                1080                1085


Glu Asp Pro Gln Cys Pro Gln Pro Leu Glu Gly Ala Trp Pro Val Thr 
    1090                1095                1100


Leu Gly Asp Ala Gln Ala Leu Lys Pro Leu Lys Phe Ser Ser Asn Gln 
1105                1110                1115                1120


Pro Pro Ala Ala Gly Ser Ser Arg Gln Asp Ala Lys Asp Pro Thr Ser 
                1125                1130                1135


Leu Leu Gly Val Leu Gln Ala Glu Ala Asp Ser Thr Ser Glu Gly Leu 
            1140                1145                1150


Glu Asp Ala Val His Ser Arg Gly Ala Arg Pro Pro Ala Ala Gly Pro 
        1155                1160                1165


Gly Gly Asp Glu Asp Glu Asp Glu Glu Asp Thr Ala Pro Glu Ser Ala 
    1170                1175                1180


Leu Asp Thr Ser Leu Asp Lys Ser Phe Ser Glu Asp Ala Val Thr Asp 
1185                1190                1195                1200


Ser Ser Gly Ser Gly Thr Leu Pro Arg Ala Arg Gly Arg Ala Ser Lys 
                1205                1210                1215


Gly Thr Gly Lys Arg Arg Lys Lys Arg Pro Ser Arg Ser Gln Glu Gly 
            1220                1225                1230


Leu Arg Pro Arg Pro Lys Ala Lys 
        1235                1240


<210>  1001
<211>  4725
<212>  DNA
<213>  Homo sapiens

<400>  1001
cgccccgcgc ccgccaggag ccaccgtccg agccttgcgg agcgcggcag tgggcgccgg     60

ctgcccgcag cccctgaccc ggccccggac ggagcgccgg ccgcaccacc gccctctggc    120

cgttgcctca ccggctcggc aagatgtcgg tgaaggaggg cgcacagcgc aagtgggcag    180

cgctgaagga gaagctgggg ccacaggatt cggaccccac ggaggccaac ctggagagcg    240

cggaccccga gctgtgcatc cggctgctcc agatgccctc tgtggtcaac tactccggcc    300

tgcgcaagcg cctggagggc agcgacggcg gctggatggt gcagttcctg gagcagagcg    360

gcctggacct gctgctggag gcgctggcgc ggctgtcggg ccgcggcgtt gcacgtatct    420

ccgacgccct gctgcagctc acctgcgtca gctgcgtgcg cgccgtcatg aactcgcggc    480

agggcatcga gtacatcctc agcaaccagg gctacgtgcg ccagctctcc caggccctgg    540

acacatccaa cgtgatggtg aagaagcagg tgtttgagct actggctgcc ctgtgcatct    600

actctcccga gggccacgtg ctgaccctgg acgccctgga ccactacaag acggtgtgca    660

gccagcagta ccgcttcagc attgtcatga acgagctctc cggcagcgac aacgtgccct    720

acgtggtcac cctgcttagc gtgatcaacg ccgtcatctt gggccccgag gacctgcgcg    780

cgcgcaccca gctgcggaac gagtttatcg ggctgcagct gctggacgtc ctggctcgcc    840

tgcgagacct ggaggatgcc gacctgctga tccagctgga ggctttcgag gaggctaagg    900

ccgaggacga ggaggagctg ctgcgagtct ctggcggggt cgacatgagc agccaccagg    960

aggtctttgc ctccctgttc cacaaggtga gctgctcccc ggtgtctgcc cagctcctgt   1020

cggtgctgca gggcctcctg cacctggagc ccaccctccg ctccagccag ctgctctggg   1080

aggccctgga gagcctcgtg aaccgggccg tgctcctggc cagcgatgcc caggaatgca   1140

ccctggagga agtggttgag cggctcctgt ctgtcaaggg gcgacccaga ccgagccccc   1200

tggtcaaggc ccataaaagc gtccaggcca acctagacca gagccagagg ggcagctccc   1260

cgcaaaacac tacaaccccc aagcccagcg tggagggcca gcagccagca gcagctgctg   1320

cctgcgagcc cgtggaccac gcccagagtg agagcatcct gaaagtttcg cagcccagag   1380

ccctggagca gcaggcgtcc accccacccc cacccccacc cccacccctg ctccctggtt   1440

ccagtgccga gccccctccc cctcccccac caccccccct gcccagtgtg ggggctaagg   1500

ccctcccaac agcacccccg cccccacccc tgccaggcct gggggccatg gcccccccag   1560

cacctcctct accaccaccc ctgccaggct cctgtgagtt cctgccccca ccacctccac   1620

cactcccggg cttgggatgc ccgcccccac ccccacccct gctgcctggt atgggctggg   1680

gccctcctcc acccccacct ccactactgc cctgcacctg cagccccccc gtggcgggag   1740

gcatggagga ggtcatcgtg gcccaggtgg accatggctt gggctcagca tgggtcccca   1800

gccatcggcg ggtgaaccca cccacactgc gcatgaagaa gctgaactgg cagaagctgc   1860

catccaacgt ggcacgtgag cacaactcta tgtgggcgtc cctgagcagc cccgacgccg   1920

aggctgtgga gcccgacttc tccagcatcg agcgactatt ctccttccct gcagccaagc   1980

ccaaggagcc caccatggtg gccccccggg ccaggaagga gcccaaggag atcactttcc   2040

tcgatgccaa gaagagcctg aacctcaaca tcttcctgaa gcaatttaag tgctccaacg   2100

aggaggtcgc tgctatgatc cgggctggag ataccaccaa gtttgatgtg gaggttctca   2160

aacaactcct taagctcctt cccgagaagc acgagattga aaacctgcgg gcattcacag   2220

aggagcgagc caagctggcc agcgccgacc acttctacct cctcctgctg gccattccct   2280

gctaccagct gcgaatcgag tgcatgctgc tgtgtgaggg cgcggccgcc gtgctggaca   2340

tggtgcggcc caaggcccag ctggtgctgg ctgcctgcga aagcctgctc accagccgcc   2400

agctgcccat cttctgccag ctgatcctga gaattgggaa cttcctcaac tacggcagcc   2460

acaccggtga cgccgacggc ttcaagatca gcacattgct gaagctcacg gagaccaagt   2520

cccagcagaa ccgcgtgacg ctgctgcacc acgtgctgga ggaagcggaa aagagccacc   2580

ccgacctcct gcagctgccc cgggacctgg aacagccctc gcaagcagca gggatcaacc   2640

tggagatcat ccgctcagag gccagctcca acctgaagaa gcttctggag accgagcgga   2700

aggtgtctgc ctccgtggcc gaggtccagg agcagtacac cgagcgcctc caggccagca   2760

tctcggcctt ccgggcactg gatgagctgt ttgaggccat cgagcagaag caacgggagc   2820

tggccgacta cctgtgtgag gacgcccagc agctgtccct ggaggacacg ttcagcacca   2880

tgaaggcttt ccgggacctt ttcctccgcg ccctgaagga gaacaaggac cggaaggagc   2940

aggcggcgaa ggcagagagg aggaagcagc agctggcgga ggaggaggcg cggcggcctc   3000

ggggagagga cgggaagcct gtcaggaagg ggcccgggaa gcaggaggag gtgtgtgtca   3060

tcgatgccct gctggctgac atcaggaagg gcttccagct gcggaagaca gcccggggcc   3120

gcggggacac cgacgggggc agcaaggcag cctccatgga tcccccaaga gccacagagc   3180

ctgtggccac cagtaaccct gcaggagatc ccgtgggcag cacgcgctgt cccgcctctg   3240

agcccggcct tgatgctaca acagccagcg agtcccgggg ctgggacctt gtagacgccg   3300

tgacccccgg ccctcagccc accctggagc agttggagga gggtggtcca cggcccctgg   3360

agaggcgttc ttcctggtat gtggatgcca gcgatgtcct aaccactgag gatccccagt   3420

gcccccagcc cttggagggg gcctggccgg tgactctggg agatgctcag gccctgaagc   3480

ccctcaagtt ctccagcaac cagccccctg cagccggaag ttcaaggcaa gatgccaagg   3540

atcccacgtc cttgctgggc gtcctccagg ccgaggccga cagcacaagt gaggggctgg   3600

aggacgctgt ccacagccgt ggtgccagac cccctgcagc aggcccaggt ggggatgagg   3660

acgaggacga ggaggacacg gccccagagt ccgcactgga cacatccctg gacaagtcct   3720

tctccgagga tgcggtgacc gactcctcgg ggtcgggcac actccccagg gcccggggcc   3780

gggcctcaaa ggggaccggg aagcgaagga agaagcgtcc ctccaggagc caggaagagg   3840

ttccccctga ttctgatgat aataaaacaa agaaactgtg tgtgatccag taaggcctca   3900

ggcccaggcc caaggccaag tgagagagcc caggccacag gacatgctgc cattctgcca   3960

agagaggctc ttctgggggc caggctggga ctgggccccg gaaaccaaaa ctccgtgcct   4020

tacccagccg gggccctcct ggagccttct tggggtgttg tggctgggaa cccgacaggc   4080

accagtgccc tgccaggcct ggtgccctcc tggaccgcct gcacgtgcca gcctcccacc   4140

tgcttcctaa aggcaaccct ggcccacacc cgcatgcgcc cggtgcagcc tgccaagggc   4200

cagtcggggg gtgctgcgtc ctgccagtgt ccaccacagc tctgcctgcc cttcagccca   4260

gcaaggttta atcaaaatgc aatgctttgc aagtctttac tgcttggagg tggctgagtt   4320

gggggccctg ggcaggggta agctggcagg cagtgccatg gcaggccagg gtcccctccc   4380

atggggtctg gcccccgttc cagcatgtcc agcccctgaa gttggagtgg ggggcggtct   4440

gcctttgctg ccactgccag gcctctgccc tgcagctgaa acttggccat cacatcaaca   4500

gaaaacccct cccagtgcca gctgcccagc gtgggcaggc cctggggaca atacaggtcc   4560

acctgagggg ctgcagggtg acacccagca gccgctgccc cctcactgcc cacccagcga   4620

gggcagccta cccgagcctg ccccctgcca ggtgtgtgcc ctgaggctgg cggctggatg   4680

cgtggccaat aaaaagcaga cctagcccgg aaaaaaaaaa aaaaa                   4725


<210>  1002
<211>  1249
<212>  PRT
<213>  Homo sapiens

<400>  1002

Met Ser Val Lys Glu Gly Ala Gln Arg Lys Trp Ala Ala Leu Lys Glu 
1               5                   10                  15


Lys Leu Gly Pro Gln Asp Ser Asp Pro Thr Glu Ala Asn Leu Glu Ser 
            20                  25                  30


Ala Asp Pro Glu Leu Cys Ile Arg Leu Leu Gln Met Pro Ser Val Val 
        35                  40                  45


Asn Tyr Ser Gly Leu Arg Lys Arg Leu Glu Gly Ser Asp Gly Gly Trp 
    50                  55                  60


Met Val Gln Phe Leu Glu Gln Ser Gly Leu Asp Leu Leu Leu Glu Ala 
65                  70                  75                  80


Leu Ala Arg Leu Ser Gly Arg Gly Val Ala Arg Ile Ser Asp Ala Leu 
                85                  90                  95


Leu Gln Leu Thr Cys Val Ser Cys Val Arg Ala Val Met Asn Ser Arg 
            100                 105                 110


Gln Gly Ile Glu Tyr Ile Leu Ser Asn Gln Gly Tyr Val Arg Gln Leu 
        115                 120                 125


Ser Gln Ala Leu Asp Thr Ser Asn Val Met Val Lys Lys Gln Val Phe 
    130                 135                 140


Glu Leu Leu Ala Ala Leu Cys Ile Tyr Ser Pro Glu Gly His Val Leu 
145                 150                 155                 160


Thr Leu Asp Ala Leu Asp His Tyr Lys Thr Val Cys Ser Gln Gln Tyr 
                165                 170                 175


Arg Phe Ser Ile Val Met Asn Glu Leu Ser Gly Ser Asp Asn Val Pro 
            180                 185                 190


Tyr Val Val Thr Leu Leu Ser Val Ile Asn Ala Val Ile Leu Gly Pro 
        195                 200                 205


Glu Asp Leu Arg Ala Arg Thr Gln Leu Arg Asn Glu Phe Ile Gly Leu 
    210                 215                 220


Gln Leu Leu Asp Val Leu Ala Arg Leu Arg Asp Leu Glu Asp Ala Asp 
225                 230                 235                 240


Leu Leu Ile Gln Leu Glu Ala Phe Glu Glu Ala Lys Ala Glu Asp Glu 
                245                 250                 255


Glu Glu Leu Leu Arg Val Ser Gly Gly Val Asp Met Ser Ser His Gln 
            260                 265                 270


Glu Val Phe Ala Ser Leu Phe His Lys Val Ser Cys Ser Pro Val Ser 
        275                 280                 285


Ala Gln Leu Leu Ser Val Leu Gln Gly Leu Leu His Leu Glu Pro Thr 
    290                 295                 300


Leu Arg Ser Ser Gln Leu Leu Trp Glu Ala Leu Glu Ser Leu Val Asn 
305                 310                 315                 320


Arg Ala Val Leu Leu Ala Ser Asp Ala Gln Glu Cys Thr Leu Glu Glu 
                325                 330                 335


Val Val Glu Arg Leu Leu Ser Val Lys Gly Arg Pro Arg Pro Ser Pro 
            340                 345                 350


Leu Val Lys Ala His Lys Ser Val Gln Ala Asn Leu Asp Gln Ser Gln 
        355                 360                 365


Arg Gly Ser Ser Pro Gln Asn Thr Thr Thr Pro Lys Pro Ser Val Glu 
    370                 375                 380


Gly Gln Gln Pro Ala Ala Ala Ala Ala Cys Glu Pro Val Asp His Ala 
385                 390                 395                 400


Gln Ser Glu Ser Ile Leu Lys Val Ser Gln Pro Arg Ala Leu Glu Gln 
                405                 410                 415


Gln Ala Ser Thr Pro Pro Pro Pro Pro Pro Pro Pro Leu Leu Pro Gly 
            420                 425                 430


Ser Ser Ala Glu Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Ser 
        435                 440                 445


Val Gly Ala Lys Ala Leu Pro Thr Ala Pro Pro Pro Pro Pro Leu Pro 
    450                 455                 460


Gly Leu Gly Ala Met Ala Pro Pro Ala Pro Pro Leu Pro Pro Pro Leu 
465                 470                 475                 480


Pro Gly Ser Cys Glu Phe Leu Pro Pro Pro Pro Pro Pro Leu Pro Gly 
                485                 490                 495


Leu Gly Cys Pro Pro Pro Pro Pro Pro Leu Leu Pro Gly Met Gly Trp 
            500                 505                 510


Gly Pro Pro Pro Pro Pro Pro Pro Leu Leu Pro Cys Thr Cys Ser Pro 
        515                 520                 525


Pro Val Ala Gly Gly Met Glu Glu Val Ile Val Ala Gln Val Asp His 
    530                 535                 540


Gly Leu Gly Ser Ala Trp Val Pro Ser His Arg Arg Val Asn Pro Pro 
545                 550                 555                 560


Thr Leu Arg Met Lys Lys Leu Asn Trp Gln Lys Leu Pro Ser Asn Val 
                565                 570                 575


Ala Arg Glu His Asn Ser Met Trp Ala Ser Leu Ser Ser Pro Asp Ala 
            580                 585                 590


Glu Ala Val Glu Pro Asp Phe Ser Ser Ile Glu Arg Leu Phe Ser Phe 
        595                 600                 605


Pro Ala Ala Lys Pro Lys Glu Pro Thr Met Val Ala Pro Arg Ala Arg 
    610                 615                 620


Lys Glu Pro Lys Glu Ile Thr Phe Leu Asp Ala Lys Lys Ser Leu Asn 
625                 630                 635                 640


Leu Asn Ile Phe Leu Lys Gln Phe Lys Cys Ser Asn Glu Glu Val Ala 
                645                 650                 655


Ala Met Ile Arg Ala Gly Asp Thr Thr Lys Phe Asp Val Glu Val Leu 
            660                 665                 670


Lys Gln Leu Leu Lys Leu Leu Pro Glu Lys His Glu Ile Glu Asn Leu 
        675                 680                 685


Arg Ala Phe Thr Glu Glu Arg Ala Lys Leu Ala Ser Ala Asp His Phe 
    690                 695                 700


Tyr Leu Leu Leu Leu Ala Ile Pro Cys Tyr Gln Leu Arg Ile Glu Cys 
705                 710                 715                 720


Met Leu Leu Cys Glu Gly Ala Ala Ala Val Leu Asp Met Val Arg Pro 
                725                 730                 735


Lys Ala Gln Leu Val Leu Ala Ala Cys Glu Ser Leu Leu Thr Ser Arg 
            740                 745                 750


Gln Leu Pro Ile Phe Cys Gln Leu Ile Leu Arg Ile Gly Asn Phe Leu 
        755                 760                 765


Asn Tyr Gly Ser His Thr Gly Asp Ala Asp Gly Phe Lys Ile Ser Thr 
    770                 775                 780


Leu Leu Lys Leu Thr Glu Thr Lys Ser Gln Gln Asn Arg Val Thr Leu 
785                 790                 795                 800


Leu His His Val Leu Glu Glu Ala Glu Lys Ser His Pro Asp Leu Leu 
                805                 810                 815


Gln Leu Pro Arg Asp Leu Glu Gln Pro Ser Gln Ala Ala Gly Ile Asn 
            820                 825                 830


Leu Glu Ile Ile Arg Ser Glu Ala Ser Ser Asn Leu Lys Lys Leu Leu 
        835                 840                 845


Glu Thr Glu Arg Lys Val Ser Ala Ser Val Ala Glu Val Gln Glu Gln 
    850                 855                 860


Tyr Thr Glu Arg Leu Gln Ala Ser Ile Ser Ala Phe Arg Ala Leu Asp 
865                 870                 875                 880


Glu Leu Phe Glu Ala Ile Glu Gln Lys Gln Arg Glu Leu Ala Asp Tyr 
                885                 890                 895


Leu Cys Glu Asp Ala Gln Gln Leu Ser Leu Glu Asp Thr Phe Ser Thr 
            900                 905                 910


Met Lys Ala Phe Arg Asp Leu Phe Leu Arg Ala Leu Lys Glu Asn Lys 
        915                 920                 925


Asp Arg Lys Glu Gln Ala Ala Lys Ala Glu Arg Arg Lys Gln Gln Leu 
    930                 935                 940


Ala Glu Glu Glu Ala Arg Arg Pro Arg Gly Glu Asp Gly Lys Pro Val 
945                 950                 955                 960


Arg Lys Gly Pro Gly Lys Gln Glu Glu Val Cys Val Ile Asp Ala Leu 
                965                 970                 975


Leu Ala Asp Ile Arg Lys Gly Phe Gln Leu Arg Lys Thr Ala Arg Gly 
            980                 985                 990


Arg Gly Asp Thr Asp Gly Gly Ser Lys Ala Ala Ser Met Asp Pro Pro 
        995                 1000                1005


Arg Ala Thr Glu Pro Val Ala Thr Ser Asn Pro Ala Gly Asp Pro Val 
    1010                1015                1020


Gly Ser Thr Arg Cys Pro Ala Ser Glu Pro Gly Leu Asp Ala Thr Thr 
1025                1030                1035                1040


Ala Ser Glu Ser Arg Gly Trp Asp Leu Val Asp Ala Val Thr Pro Gly 
                1045                1050                1055


Pro Gln Pro Thr Leu Glu Gln Leu Glu Glu Gly Gly Pro Arg Pro Leu 
            1060                1065                1070


Glu Arg Arg Ser Ser Trp Tyr Val Asp Ala Ser Asp Val Leu Thr Thr 
        1075                1080                1085


Glu Asp Pro Gln Cys Pro Gln Pro Leu Glu Gly Ala Trp Pro Val Thr 
    1090                1095                1100


Leu Gly Asp Ala Gln Ala Leu Lys Pro Leu Lys Phe Ser Ser Asn Gln 
1105                1110                1115                1120


Pro Pro Ala Ala Gly Ser Ser Arg Gln Asp Ala Lys Asp Pro Thr Ser 
                1125                1130                1135


Leu Leu Gly Val Leu Gln Ala Glu Ala Asp Ser Thr Ser Glu Gly Leu 
            1140                1145                1150


Glu Asp Ala Val His Ser Arg Gly Ala Arg Pro Pro Ala Ala Gly Pro 
        1155                1160                1165


Gly Gly Asp Glu Asp Glu Asp Glu Glu Asp Thr Ala Pro Glu Ser Ala 
    1170                1175                1180


Leu Asp Thr Ser Leu Asp Lys Ser Phe Ser Glu Asp Ala Val Thr Asp 
1185                1190                1195                1200


Ser Ser Gly Ser Gly Thr Leu Pro Arg Ala Arg Gly Arg Ala Ser Lys 
                1205                1210                1215


Gly Thr Gly Lys Arg Arg Lys Lys Arg Pro Ser Arg Ser Gln Glu Glu 
            1220                1225                1230


Val Pro Pro Asp Ser Asp Asp Asn Lys Thr Lys Lys Leu Cys Val Ile 
        1235                1240                1245


Gln 



<210>  1003
<211>  1704
<212>  DNA
<213>  Homo sapiens

<400>  1003
aggagccacc gtccgagcct tgcggagcgc ggcagtgggc gccggctgcc cgcagcccct     60

gacccggccc cggacggagc gccggccgca ccaccgccct ctggccgttg cctcaccggc    120

tcggcaagat gtcggtgaag gagggcgcac agcgcaagtg ggcagcgctg aaggagaagc    180

tggggccaca ggattcggac cccacggagg ccaacctgga gagcgcggac cctgagctgt    240

gcatccggct gctccagatg ccctctgtgg tcaactactc cggcctgcgc aagcgcctgg    300

agggcagcga cggcggctgg atggtgcagt tcctggagca gagcggcctg gacctgctgc    360

tggaggcgct ggcgcggctg tcgggccgcg gcgttgcacg tatctccgac gccctgctgc    420

agctcacctg cgtcagctgc gtgcgcgccg tcatgaactc gcggcagggc atcgagtaca    480

tcctcagcaa ccagggctac gtgcgccagc tctcccaggc cctggacaca tccaacgtga    540

tggtgaagaa gcaggtgttt gagctactgg ctgccctgtg catctactct cccgagggcc    600

acgtgctgac cctggacgcc ctggaccact acaagacggt gtgcagccag cagtaccgct    660

tcagcattgt catgaacgag ctctccggca gcgacaacgt gccctacgtg gtcaccctgc    720

ttagcgtgat caacgccgtc atcttgggcc ccgaggacct gcgcgcgcgc acccagctgc    780

ggaacgagtt tatcgggctg cagctgctgg acgtcctggc tcgcctgcgg tgagtcccca    840

ctgtagcggt cctgccggct ccccctcctg ctcccaaggc caggcccacc tgccctttgg    900

ctcccagcca cctcacctaa gcagcacctc cagatggcag ggaggtggct ccctcggagt    960

aaccccaggg gtccagccag aagccaggtc tcaggctaga atccagctca ctgtccctgg   1020

cagctgccca cagaaactag ggttgcagca gccatagaaa ggacagaatg agctcatatc   1080

ctttgcacac cgtggatgga gctggaggcc gtgatcctaa gtgaaccaac ccagaaacag   1140

aaaatgaaat gccaataaga gggaactaca gggtggttca cgtggacgca agatggagac   1200

agggacacgg gctccagggc gagagttgaa aaactaccta cagggtacag tgttcgtcgc   1260

tacttggtgt caggcccact agaacaaggg tccccaaccg ccaggctgcg gaccggtacc   1320

tggcctattg gaaccgggcc acgcagcagg aagtgagcgg tgggcgggca ttcctgcctg   1380

agctgcacct catgtcagat cagcactgca ttagattctc cagcgcacgc acgcgcgcaa   1440

gggatccagg ctgcgcgctc ctcatgacaa tctaatgcct gatgatcggg ggtggaacag   1500

ttttatccct aaaccattcc cgtcacccca gtctatggaa aaattgtctt ccacaaaacc   1560

agtccctggt gccaaaaagg ctggggacca ctgccctaga aggcaaatcg cctacgttac   1620

acagtgtacc atgtggcaaa cacgcacatg tacccccgag tctaaaataa aaatttttta   1680

aaaaagaaaa aaaaaaaaaa aaaa                                          1704


<210>  1004
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  1004

Met Ser Val Lys Glu Gly Ala Gln Arg Lys Trp Ala Ala Leu Lys Glu 
1               5                   10                  15


Lys Leu Gly Pro Gln Asp Ser Asp Pro Thr Glu Ala Asn Leu Glu Ser 
            20                  25                  30


Ala Asp Pro Glu Leu Cys Ile Arg Leu Leu Gln Met Pro Ser Val Val 
        35                  40                  45


Asn Tyr Ser Gly Leu Arg Lys Arg Leu Glu Gly Ser Asp Gly Gly Trp 
    50                  55                  60


Met Val Gln Phe Leu Glu Gln Ser Gly Leu Asp Leu Leu Leu Glu Ala 
65                  70                  75                  80


Leu Ala Arg Leu Ser Gly Arg Gly Val Ala Arg Ile Ser Asp Ala Leu 
                85                  90                  95


Leu Gln Leu Thr Cys Val Ser Cys Val Arg Ala Val Met Asn Ser Arg 
            100                 105                 110


Gln Gly Ile Glu Tyr Ile Leu Ser Asn Gln Gly Tyr Val Arg Gln Leu 
        115                 120                 125


Ser Gln Ala Leu Asp Thr Ser Asn Val Met Val Lys Lys Gln Val Phe 
    130                 135                 140


Glu Leu Leu Ala Ala Leu Cys Ile Tyr Ser Pro Glu Gly His Val Leu 
145                 150                 155                 160


Thr Leu Asp Ala Leu Asp His Tyr Lys Thr Val Cys Ser Gln Gln Tyr 
                165                 170                 175


Arg Phe Ser Ile Val Met Asn Glu Leu Ser Gly Ser Asp Asn Val Pro 
            180                 185                 190


Tyr Val Val Thr Leu Leu Ser Val Ile Asn Ala Val Ile Leu Gly Pro 
        195                 200                 205


Glu Asp Leu Arg Ala Arg Thr Gln Leu Arg Asn Glu Phe Ile Gly Leu 
    210                 215                 220


Gln Leu Leu Asp Val Leu Ala Arg Leu Arg 
225                 230


<210>  1005
<211>  1769
<212>  DNA
<213>  Homo sapiens

<400>  1005
ctccatttaa tggcgcggac gccggcggcg gcgggctcct ggccgggcca gcgcagcgga     60

agagccaagc cagcatgtcg gggacccgag cctccaacga ccggcccccc ggcgcaggcg    120

gcgtcaagcg ggggcggctg cagcaggagg cggcggcgac cggctcccgc gtgacggtgg    180

tgctgggcgc gcagtggggg gacgagggca aaggcaaggt ggtggacctg ctggccacgg    240

acgccgacat catcagccgc tgccaggggg gcaacaacgc cggccacacg gtggtggtgg    300

atgggaaaga gtacgacttc cacctgctgc ccagcggcat catcaacacc aaggccgtgt    360

ccttcattgg caacggggtg gtcatccact tgccaggctt gtttgaggaa gcagagaaga    420

atgaaaagaa aggcctgaag gactgggaga agaggctcat catctctgac agagcccacc    480

ttgtgtttga ttttcaccag gctgtcgacg gacttcagga agtgcagcgc caggcacaag    540

aggggaagaa tataggcacc accaagaagg gaatcggacc aacctactct tccaaagctg    600

cccggacagg cctccgcatc tgcgacctcc tgtcagattt tgatgagttt tcctccagat    660

tcaagaacct ggcccaccag caccagtcga tgttccccac cctggaaata gacattgaag    720

gccaactcaa aaggctcaag ggctttgctg agcggatcag acccatggtc cgagatggtg    780

tttactttat gtatgaggca ctccacggcc cccccaagaa gatcctggtg gagggtgcca    840

acgccgccct cctcgacatt gacttcggga cctacccctt tgtgacttca tccaactgca    900

ccgtgggcgg tgtgtgcacg ggcctgggca tccccccgca gaacataggt gacgtgtatg    960

gcgtggtgaa agcctatacc acacgtgtgg gcatcggggc cttccccacc gagcagatca   1020

acgagattgg aggcctgctg cagacccgcg gccacgagtg gggagtgacc acaggcagga   1080

agaggcgctg cggctggctc gacctgatga ttctaagata tgctcacatg gtcaacggat   1140

tcactgcgct ggccctgacg aagctggaca tcctggacgt actgggtgag gttaaagtcg   1200

gtgtctcata caagctgaac gggaaaagga ttccctattt cccagctaac caggagatgc   1260

ttcagaaggt cgaagttgag tatgaaacgc tgcctgggtg gaaagcagac accacaggcg   1320

ccaggaggtg ggaggacctg cccccacagg cccagaacta catccgcttt gtggagaatc   1380

acgtgggagt cgcagtcaaa tgggttggtg ttggcaagtc aagagagtcg atgatccagc   1440

tgttttagtc acagactgag ctgatcccaa caggccctgg cagcgtctgg acttgtgtaa   1500

acagcagcag tcacgttcct cggccgccac aaccaacacc aaagcaggaa aaccattttc   1560

tgtactttta tatttctgtt caacctgttg gtttctacaa tgattttaaa cattggaaag   1620

ccagccttgt gtatattttt aaaaattata ttcaaaatga gccaaagtgc tcagagacct   1680

tctatgacac attagtgtca catggttgcg tgtccagccg aagcagtgta ataaacatct   1740

ccaatggcca ctgaaaaaaa aaaaaaaaa                                     1769


<210>  1006
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  1006

Met Ser Gly Thr Arg Ala Ser Asn Asp Arg Pro Pro Gly Ala Gly Gly 
1               5                   10                  15


Val Lys Arg Gly Arg Leu Gln Gln Glu Ala Ala Ala Thr Gly Ser Arg 
            20                  25                  30


Val Thr Val Val Leu Gly Ala Gln Trp Gly Asp Glu Gly Lys Gly Lys 
        35                  40                  45


Val Val Asp Leu Leu Ala Thr Asp Ala Asp Ile Ile Ser Arg Cys Gln 
    50                  55                  60


Gly Gly Asn Asn Ala Gly His Thr Val Val Val Asp Gly Lys Glu Tyr 
65                  70                  75                  80


Asp Phe His Leu Leu Pro Ser Gly Ile Ile Asn Thr Lys Ala Val Ser 
                85                  90                  95


Phe Ile Gly Asn Gly Val Val Ile His Leu Pro Gly Leu Phe Glu Glu 
            100                 105                 110


Ala Glu Lys Asn Glu Lys Lys Gly Leu Lys Asp Trp Glu Lys Arg Leu 
        115                 120                 125


Ile Ile Ser Asp Arg Ala His Leu Val Phe Asp Phe His Gln Ala Val 
    130                 135                 140


Asp Gly Leu Gln Glu Val Gln Arg Gln Ala Gln Glu Gly Lys Asn Ile 
145                 150                 155                 160


Gly Thr Thr Lys Lys Gly Ile Gly Pro Thr Tyr Ser Ser Lys Ala Ala 
                165                 170                 175


Arg Thr Gly Leu Arg Ile Cys Asp Leu Leu Ser Asp Phe Asp Glu Phe 
            180                 185                 190


Ser Ser Arg Phe Lys Asn Leu Ala His Gln His Gln Ser Met Phe Pro 
        195                 200                 205


Thr Leu Glu Ile Asp Ile Glu Gly Gln Leu Lys Arg Leu Lys Gly Phe 
    210                 215                 220


Ala Glu Arg Ile Arg Pro Met Val Arg Asp Gly Val Tyr Phe Met Tyr 
225                 230                 235                 240


Glu Ala Leu His Gly Pro Pro Lys Lys Ile Leu Val Glu Gly Ala Asn 
                245                 250                 255


Ala Ala Leu Leu Asp Ile Asp Phe Gly Thr Tyr Pro Phe Val Thr Ser 
            260                 265                 270


Ser Asn Cys Thr Val Gly Gly Val Cys Thr Gly Leu Gly Ile Pro Pro 
        275                 280                 285


Gln Asn Ile Gly Asp Val Tyr Gly Val Val Lys Ala Tyr Thr Thr Arg 
    290                 295                 300


Val Gly Ile Gly Ala Phe Pro Thr Glu Gln Ile Asn Glu Ile Gly Gly 
305                 310                 315                 320


Leu Leu Gln Thr Arg Gly His Glu Trp Gly Val Thr Thr Gly Arg Lys 
                325                 330                 335


Arg Arg Cys Gly Trp Leu Asp Leu Met Ile Leu Arg Tyr Ala His Met 
            340                 345                 350


Val Asn Gly Phe Thr Ala Leu Ala Leu Thr Lys Leu Asp Ile Leu Asp 
        355                 360                 365


Val Leu Gly Glu Val Lys Val Gly Val Ser Tyr Lys Leu Asn Gly Lys 
    370                 375                 380


Arg Ile Pro Tyr Phe Pro Ala Asn Gln Glu Met Leu Gln Lys Val Glu 
385                 390                 395                 400


Val Glu Tyr Glu Thr Leu Pro Gly Trp Lys Ala Asp Thr Thr Gly Ala 
                405                 410                 415


Arg Arg Trp Glu Asp Leu Pro Pro Gln Ala Gln Asn Tyr Ile Arg Phe 
            420                 425                 430


Val Glu Asn His Val Gly Val Ala Val Lys Trp Val Gly Val Gly Lys 
        435                 440                 445


Ser Arg Glu Ser Met Ile Gln Leu Phe 
    450                 455


<210>  1007
<211>  1826
<212>  DNA
<213>  Homo sapiens

<400>  1007
gcatggtggg gaggagctgt ggggtggcaa cccagaggca aggaggtggg cagaggccca     60

cgaacctggc cctgaccctc agctcgtccc cagctcacag cacagccctc ccctggctgc    120

ctccaaggag tctccagtta ctgagtggcc actccgtgcc agctcagccc acccctcacc    180

ttcccagtgc ctgtggaggc ccaactaggg tgacgctggg agaggagagg gcttggagga    240

gccacgggtc aaatgcagga ggccacacct gcctgcccag gaggactgca ggagccggat    300

ccttaacacc tggaggggag cgggggggca acaacgccgg ccacacggtg gtggtggatg    360

ggaaagagta cgacttccac ctgctgccca gcggcatcat caacaccaag gccgtgtcct    420

tcattggcaa cggggtggtc atccacttgc caggcttgtt tgaggaagca gagaagaatg    480

aaaagaaagg cctgaaggac tgggagaaga ggctcatcat ctctgacaga gcccaccttg    540

tgtttgattt tcaccaggct gtcgacggac ttcaggaagt gcagcgccag gcacaagagg    600

ggaagaatat aggcaccacc aagaagggaa tcggaccaac ctactcttcc aaagctgccc    660

ggacaggcct ccgcatctgc gacctcctgt cagattttga tgagttttcc tccagattca    720

agaacctggc ccaccagcac cagtcgatgt tccccaccct ggaaatagac attgaaggcc    780

aactcaaaag gctcaagggc tttgctgagc ggatcagacc catggtccga gatggtgttt    840

actttatgta tgaggcactc cacggccccc ccaagaagat cctggtggag ggtgccaacg    900

ccgccctcct cgacattgac ttcgggacct acccctttgt gacttcatcc aactgcaccg    960

tgggcggtgt gtgcacgggc ctgggcatcc ccccgcagaa cataggtgac gtgtatggcg   1020

tggtgaaagc ctataccaca cgtgtgggca tcggggcctt ccccaccgag cagatcaacg   1080

agattggagg cctgctgcag acccgcggcc acgagtgggg agtgaccaca ggcaggaaga   1140

ggcgctgcgg ctggctcgac ctgatgattc taagatatgc tcacatggtc aacggattca   1200

ctgcgctggc cctgacgaag ctggacatcc tggacgtact gggtgaggtt aaagtcggtg   1260

tctcatacaa gctgaacggg aaaaggattc cctatttccc agctaaccag gagatgcttc   1320

agaaggtcga agttgagtat gaaacgctgc ctgggtggaa agcagacacc acaggcgcca   1380

ggaggtggga ggacctgccc ccacaggccc agaactacat ccgctttgtg gagaatcacg   1440

tgggagtcgc agtcaaatgg gttggtgttg gcaagtcaag agagtcgatg atccagctgt   1500

tttagtcaca gactgagctg atcccaacag gccctggcag cgtctggact tgtgtaaaca   1560

gcagcagtca cgttcctcgg ccgccacaac caacaccaaa gcaggaaaac cattttctgt   1620

acttttatat ttctgttcaa cctgttggtt tctacaatga ttttaaacat tggaaagcca   1680

gccttgtgta tatttttaaa aattatattc aaaatgagcc aaagtgctca gagaccttct   1740

atgacacatt agtgtcacat ggttgcgtgt ccagccgaag cagtgtaata aacatctcca   1800

atggccactg aaaaaaaaaa aaaaaa                                        1826


<210>  1008
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  1008

Met Val Gly Arg Ser Cys Gly Val Ala Thr Gln Arg Gln Gly Gly Gly 
1               5                   10                  15


Gln Arg Pro Thr Asn Leu Ala Leu Thr Leu Ser Ser Ser Pro Ala His 
            20                  25                  30


Ser Thr Ala Leu Pro Trp Leu Pro Pro Arg Ser Leu Gln Leu Leu Ser 
        35                  40                  45


Gly His Ser Val Pro Ala Gln Pro Thr Pro His Leu Pro Ser Ala Cys 
    50                  55                  60


Gly Gly Pro Thr Arg Val Thr Leu Gly Glu Glu Arg Ala Trp Arg Ser 
65                  70                  75                  80


His Gly Ser Asn Ala Gly Gly His Thr Cys Leu Pro Arg Arg Thr Ala 
                85                  90                  95


Gly Ala Gly Ser Leu Thr Pro Gly Gly Glu Arg Gly Gly Asn Asn Ala 
            100                 105                 110


Gly His Thr Val Val Val Asp Gly Lys Glu Tyr Asp Phe His Leu Leu 
        115                 120                 125


Pro Ser Gly Ile Ile Asn Thr Lys Ala Val Ser Phe Ile Gly Asn Gly 
    130                 135                 140


Val Val Ile His Leu Pro Gly Leu Phe Glu Glu Ala Glu Lys Asn Glu 
145                 150                 155                 160


Lys Lys Gly Leu Lys Asp Trp Glu Lys Arg Leu Ile Ile Ser Asp Arg 
                165                 170                 175


Ala His Leu Val Phe Asp Phe His Gln Ala Val Asp Gly Leu Gln Glu 
            180                 185                 190


Val Gln Arg Gln Ala Gln Glu Gly Lys Asn Ile Gly Thr Thr Lys Lys 
        195                 200                 205


Gly Ile Gly Pro Thr Tyr Ser Ser Lys Ala Ala Arg Thr Gly Leu Arg 
    210                 215                 220


Ile Cys Asp Leu Leu Ser Asp Phe Asp Glu Phe Ser Ser Arg Phe Lys 
225                 230                 235                 240


Asn Leu Ala His Gln His Gln Ser Met Phe Pro Thr Leu Glu Ile Asp 
                245                 250                 255


Ile Glu Gly Gln Leu Lys Arg Leu Lys Gly Phe Ala Glu Arg Ile Arg 
            260                 265                 270


Pro Met Val Arg Asp Gly Val Tyr Phe Met Tyr Glu Ala Leu His Gly 
        275                 280                 285


Pro Pro Lys Lys Ile Leu Val Glu Gly Ala Asn Ala Ala Leu Leu Asp 
    290                 295                 300


Ile Asp Phe Gly Thr Tyr Pro Phe Val Thr Ser Ser Asn Cys Thr Val 
305                 310                 315                 320


Gly Gly Val Cys Thr Gly Leu Gly Ile Pro Pro Gln Asn Ile Gly Asp 
                325                 330                 335


Val Tyr Gly Val Val Lys Ala Tyr Thr Thr Arg Val Gly Ile Gly Ala 
            340                 345                 350


Phe Pro Thr Glu Gln Ile Asn Glu Ile Gly Gly Leu Leu Gln Thr Arg 
        355                 360                 365


Gly His Glu Trp Gly Val Thr Thr Gly Arg Lys Arg Arg Cys Gly Trp 
    370                 375                 380


Leu Asp Leu Met Ile Leu Arg Tyr Ala His Met Val Asn Gly Phe Thr 
385                 390                 395                 400


Ala Leu Ala Leu Thr Lys Leu Asp Ile Leu Asp Val Leu Gly Glu Val 
                405                 410                 415


Lys Val Gly Val Ser Tyr Lys Leu Asn Gly Lys Arg Ile Pro Tyr Phe 
            420                 425                 430


Pro Ala Asn Gln Glu Met Leu Gln Lys Val Glu Val Glu Tyr Glu Thr 
        435                 440                 445


Leu Pro Gly Trp Lys Ala Asp Thr Thr Gly Ala Arg Arg Trp Glu Asp 
    450                 455                 460


Leu Pro Pro Gln Ala Gln Asn Tyr Ile Arg Phe Val Glu Asn His Val 
465                 470                 475                 480


Gly Val Ala Val Lys Trp Val Gly Val Gly Lys Ser Arg Glu Ser Met 
                485                 490                 495


Ile Gln Leu Phe 
            500


<210>  1009
<211>  790
<212>  DNA
<213>  Homo sapiens

<400>  1009
tgtgacgtca cggcgtcgtt ggtaaggggc tggcggccgg ggagctgcgt agctcccggc     60

cccgcggcca tgcccaagcg gagctgcccc ttcgcggacg tggccccgct acagctcaag    120

gtccgcgtga gccagaggga gttgagccgc ggcgtgtgcg ccgagcgcta ctcgcaggag    180

gtcttcgaga agaccaagcg actcctgttc ctcggggccc aggcctacct ggaccacgtg    240

tgggatgaag gctgtgccgt cgttcacctg ccagagtccc caaagcctgg ccctacaggg    300

gccccgaggg ctgcacgtgg gcagatgctg attggaccag acggccgcct gatcaggagc    360

cttgggcagg cctccgaagc tgacccatct ggggtagcgt ccattgcctg ttcctcatgc    420

gtgcgagccg tggatgggaa ggcggtctgc ggtcagtgtg agcgagccct gtgcgggcag    480

tgtgtgcgca cctgctgggg ctgcggctcc gtggcctgta ccctgtgtgg cctcgtggac    540

tgcagtgaca tgtacgagaa agtgctgtgc accagctgtg ccatgttcga gacctgaggc    600

tggctcaagc cggctgcctt caccgggagc cacgccgtgc atggcagcct tccctggacg    660

agcgctcggt gttcacactg aactgtgggg tcgacgggag gggtgccttt tacatgttct    720

attttgtatc ctaatgacag aatgaataaa cctctttata tttgcacaag aaaaaaaaaa    780

aaaaaaaaaa                                                           790


<210>  1010
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  1010

Met Pro Lys Arg Ser Cys Pro Phe Ala Asp Val Ala Pro Leu Gln Leu 
1               5                   10                  15


Lys Val Arg Val Ser Gln Arg Glu Leu Ser Arg Gly Val Cys Ala Glu 
            20                  25                  30


Arg Tyr Ser Gln Glu Val Phe Glu Lys Thr Lys Arg Leu Leu Phe Leu 
        35                  40                  45


Gly Ala Gln Ala Tyr Leu Asp His Val Trp Asp Glu Gly Cys Ala Val 
    50                  55                  60


Val His Leu Pro Glu Ser Pro Lys Pro Gly Pro Thr Gly Ala Pro Arg 
65                  70                  75                  80


Ala Ala Arg Gly Gln Met Leu Ile Gly Pro Asp Gly Arg Leu Ile Arg 
                85                  90                  95


Ser Leu Gly Gln Ala Ser Glu Ala Asp Pro Ser Gly Val Ala Ser Ile 
            100                 105                 110


Ala Cys Ser Ser Cys Val Arg Ala Val Asp Gly Lys Ala Val Cys Gly 
        115                 120                 125


Gln Cys Glu Arg Ala Leu Cys Gly Gln Cys Val Arg Thr Cys Trp Gly 
    130                 135                 140


Cys Gly Ser Val Ala Cys Thr Leu Cys Gly Leu Val Asp Cys Ser Asp 
145                 150                 155                 160


Met Tyr Glu Lys Val Leu Cys Thr Ser Cys Ala Met Phe Glu Thr 
                165                 170                 175


<210>  1011
<211>  595
<212>  DNA
<213>  Homo sapiens

<400>  1011
tgtgacgtca cggcgtcgtt ggtaaggggc tggcggccgg ggagctgcgt agctcccggc     60

cccgcggcca tgcccaagcg gagctgcccc ttcgcggacg tggccccgct acagctcaag    120

gtccgcgtga gccagaggga gttgagccgc ggcgtgtgcg ccgagcgcta ctcgcaggag    180

gtcttcgacc catctggggt agcgtccatt gcctgttcct catgcgtgcg agccgtggat    240

gggaaggcgg tctgcggtca gtgtgagcga gccctgtgcg ggcagtgtgt gcgcacctgc    300

tggggctgcg gctccgtggc ctgtaccctg tgtggcctcg tggactgcag tgacatgtac    360

gagaaagtgc tgtgcaccag ctgtgccatg ttcgagacct gaggctggct caagccggct    420

gccttcaccg ggagccacgc cgtgcatggc agccttccct ggacgagcgc tcggtgttca    480

cactgaactg tggggtcgac gggaggggtg ccttttacat gttctatttt gtatcctaat    540

gacagaatga ataaacctct ttatatttgc acaagaaaaa aaaaaaaaaa aaaaa         595


<210>  1012
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  1012

Met Pro Lys Arg Ser Cys Pro Phe Ala Asp Val Ala Pro Leu Gln Leu 
1               5                   10                  15


Lys Val Arg Val Ser Gln Arg Glu Leu Ser Arg Gly Val Cys Ala Glu 
            20                  25                  30


Arg Tyr Ser Gln Glu Val Phe Asp Pro Ser Gly Val Ala Ser Ile Ala 
        35                  40                  45


Cys Ser Ser Cys Val Arg Ala Val Asp Gly Lys Ala Val Cys Gly Gln 
    50                  55                  60


Cys Glu Arg Ala Leu Cys Gly Gln Cys Val Arg Thr Cys Trp Gly Cys 
65                  70                  75                  80


Gly Ser Val Ala Cys Thr Leu Cys Gly Leu Val Asp Cys Ser Asp Met 
                85                  90                  95


Tyr Glu Lys Val Leu Cys Thr Ser Cys Ala Met Phe Glu Thr 
            100                 105                 110


<210>  1013
<211>  2794
<212>  DNA
<213>  Homo sapiens

<400>  1013
cggcaggacc gagcgcggca ggcggctggc ccagcgcagc cagcgcggcc cgaaggacgg     60

gagcaggcgg ccgagcaccg agcgctgggc accgggcacc gagcggcggc ggcacgcgag    120

gcccggcccc gagcagcgcc cccgcccgcc gcggcctcca gcccggcccc gcccagcgcc    180

ggcccgcggg gatgcggagc ggcgggcgcc ggaggccgcg gcccggctag gcccgcgctc    240

gcgcccggac gcggcggccc gaggctgtgg ccaggccagc tgggctcggg gagcgccagc    300

ctgagaggag cgcgtgagcg tcgcgggagc ctcgggcacc atgagcgacg tggctattgt    360

gaaggagggt tggctgcaca aacgagggga gtacatcaag acctggcggc cacgctactt    420

cctcctcaag aatgatggca ccttcattgg ctacaaggag cggccgcagg atgtggacca    480

acgtgaggct cccctcaaca acttctctgt ggcgcagtgc cagctgatga agacggagcg    540

gccccggccc aacaccttca tcatccgctg cctgcagtgg accactgtca tcgaacgcac    600

cttccatgtg gagactcctg aggagcggga ggagtggaca accgccatcc agactgtggc    660

tgacggcctc aagaagcagg aggaggagga gatggacttc cggtcgggct cacccagtga    720

caactcaggg gctgaagaga tggaggtgtc cctggccaag cccaagcacc gcgtgaccat    780

gaacgagttt gagtacctga agctgctggg caagggcact ttcggcaagg tgatcctggt    840

gaaggagaag gccacaggcc gctactacgc catgaagatc ctcaagaagg aagtcatcgt    900

ggccaaggac gaggtggccc acacactcac cgagaaccgc gtcctgcaga actccaggca    960

ccccttcctc acagccctga agtactcttt ccagacccac gaccgcctct gctttgtcat   1020

ggagtacgcc aacgggggcg agctgttctt ccacctgtcc cgggagcgtg tgttctccga   1080

ggaccgggcc cgcttctatg gcgctgagat tgtgtcagcc ctggactacc tgcactcgga   1140

gaagaacgtg gtgtaccggg acctcaagct ggagaacctc atgctggaca aggacgggca   1200

cattaagatc acagacttcg ggctgtgcaa ggaggggatc aaggacggtg ccaccatgaa   1260

gaccttttgc ggcacacctg agtacctggc ccccgaggtg ctggaggaca atgactacgg   1320

ccgtgcagtg gactggtggg ggctgggcgt ggtcatgtac gagatgatgt gcggtcgcct   1380

gcccttctac aaccaggacc atgagaagct ttttgagctc atcctcatgg aggagatccg   1440

cttcccgcgc acgcttggtc ccgaggccaa gtccttgctt tcagggctgc tcaagaagga   1500

ccccaagcag aggcttggcg ggggctccga ggacgccaag gagatcatgc agcatcgctt   1560

ctttgccggt atcgtgtggc agcacgtgta cgagaagaag ctcagcccac ccttcaagcc   1620

ccaggtcacg tcggagactg acaccaggta ttttgatgag gagttcacgg cccagatgat   1680

caccatcaca ccacctgacc aagatgacag catggagtgt gtggacagcg agcgcaggcc   1740

ccacttcccc cagttctcct actcggccag cggcacggcc tgaggcggcg gtggactgcg   1800

ctggacgata gcttggaggg atggagaggc ggcctcgtgc catgatctgt atttaatggt   1860

ttttatttct cgggtgcatt tgagagaagc cacgctgtcc tctcgagccc agatggaaag   1920

acgtttttgt gctgtgggca gcaccctccc ccgcagcggg gtagggaaga aaactatcct   1980

gcgggtttta atttatttca tccagtttgt tctccgggtg tggcctcagc cctcagaaca   2040

atccgattca cgtagggaaa tgttaaggac ttctgcagct atgcgcaatg tggcattggg   2100

gggccgggca ggtcctgccc atgtgtcccc tcactctgtc agccagccgc cctgggctgt   2160

ctgtcaccag ctatctgtca tctctctggg gccctgggcc tcagttcaac ctggtggcac   2220

cagatgcaac ctcactatgg tatgctggcc agcaccctct cctgggggtg gcaggcacac   2280

agcagccccc cagcactaag gccgtgtctc tgaggacgtc atcggaggct gggcccctgg   2340

gatgggacca gggatggggg atgggccagg gtttacccag tgggacagag gagcaaggtt   2400

taaatttgtt attgtgtatt atgttgttca aatgcatttt gggggttttt aatctttgtg   2460

acaggaaagc cctccccctt ccccttctgt gtcacagttc ttggtgactg tcccaccggg   2520

agcctccccc tcagatgatc tctccacggt agcacttgac cttttcgacg cttaaccttt   2580

ccgctgtcgc cccaggccct ccctgactcc ctgtgggggt ggccatccct gggcccctcc   2640

acgcctcctg gccagacgct gccgctgccg ctgcaccacg gcgttttttt acaacattca   2700

actttagtat ttttactatt ataatataat atggaacctt ccctccaaat tcttcaataa   2760

aagttgcttt tcaaaaaaaa aaaaaaaaaa aaaa                               2794


<210>  1014
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  1014

Met Ser Asp Val Ala Ile Val Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15


Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp 
            20                  25                  30


Gly Thr Phe Ile Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg 
        35                  40                  45


Glu Ala Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys 
    50                  55                  60


Thr Glu Arg Pro Arg Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80


Thr Thr Val Ile Glu Arg Thr Phe His Val Glu Thr Pro Glu Glu Arg 
                85                  90                  95


Glu Glu Trp Thr Thr Ala Ile Gln Thr Val Ala Asp Gly Leu Lys Lys 
            100                 105                 110


Gln Glu Glu Glu Glu Met Asp Phe Arg Ser Gly Ser Pro Ser Asp Asn 
        115                 120                 125


Ser Gly Ala Glu Glu Met Glu Val Ser Leu Ala Lys Pro Lys His Arg 
    130                 135                 140


Val Thr Met Asn Glu Phe Glu Tyr Leu Lys Leu Leu Gly Lys Gly Thr 
145                 150                 155                 160


Phe Gly Lys Val Ile Leu Val Lys Glu Lys Ala Thr Gly Arg Tyr Tyr 
                165                 170                 175


Ala Met Lys Ile Leu Lys Lys Glu Val Ile Val Ala Lys Asp Glu Val 
            180                 185                 190


Ala His Thr Leu Thr Glu Asn Arg Val Leu Gln Asn Ser Arg His Pro 
        195                 200                 205


Phe Leu Thr Ala Leu Lys Tyr Ser Phe Gln Thr His Asp Arg Leu Cys 
    210                 215                 220


Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His Leu Ser 
225                 230                 235                 240


Arg Glu Arg Val Phe Ser Glu Asp Arg Ala Arg Phe Tyr Gly Ala Glu 
                245                 250                 255


Ile Val Ser Ala Leu Asp Tyr Leu His Ser Glu Lys Asn Val Val Tyr 
            260                 265                 270


Arg Asp Leu Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile 
        275                 280                 285


Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala 
    290                 295                 300


Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val 
305                 310                 315                 320


Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly 
                325                 330                 335


Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln 
            340                 345                 350


Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg Phe 
        355                 360                 365


Pro Arg Thr Leu Gly Pro Glu Ala Lys Ser Leu Leu Ser Gly Leu Leu 
    370                 375                 380


Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Ser Glu Asp Ala Lys 
385                 390                 395                 400


Glu Ile Met Gln His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val 
                405                 410                 415


Tyr Glu Lys Lys Leu Ser Pro Pro Phe Lys Pro Gln Val Thr Ser Glu 
            420                 425                 430


Thr Asp Thr Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Met Ile Thr 
        435                 440                 445


Ile Thr Pro Pro Asp Gln Asp Asp Ser Met Glu Cys Val Asp Ser Glu 
    450                 455                 460


Arg Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Thr Ala 
465                 470                 475                 480


<210>  1015
<211>  2878
<212>  DNA
<213>  Homo sapiens

<400>  1015
cggcaggacc gagcgcggca ggcggctggc ccagcgcagc cagcgcggcc cgaaggacgg     60

gagcaggcgg ccgagcaccg agcgctgggc accgggcacc gagcggcggc ggcacgcgag    120

gcccggcccc gagcagcgcc cccgcccgcc gcggcctcca gcccggcccc gcccagcgcc    180

ggcccgcggg gatgcggagc ggcgggcgcc ggaggccgcg gcccggctag gcccgcgctc    240

gcgcccggac gcggcggccc ggggcttagg gaaggccgag ccagcctggg tcaaagaagt    300

caaaggggct gcctggagga ggcagcctgt cagctggtgc atcagaggct gtggccaggc    360

cagctgggct cggggagcgc cagcctgaga ggagcgcgtg agcgtcgcgg gagcctcggg    420

caccatgagc gacgtggcta ttgtgaagga gggttggctg cacaaacgag gggagtacat    480

caagacctgg cggccacgct acttcctcct caagaatgat ggcaccttca ttggctacaa    540

ggagcggccg caggatgtgg accaacgtga ggctcccctc aacaacttct ctgtggcgca    600

gtgccagctg atgaagacgg agcggccccg gcccaacacc ttcatcatcc gctgcctgca    660

gtggaccact gtcatcgaac gcaccttcca tgtggagact cctgaggagc gggaggagtg    720

gacaaccgcc atccagactg tggctgacgg cctcaagaag caggaggagg aggagatgga    780

cttccggtcg ggctcaccca gtgacaactc aggggctgaa gagatggagg tgtccctggc    840

caagcccaag caccgcgtga ccatgaacga gtttgagtac ctgaagctgc tgggcaaggg    900

cactttcggc aaggtgatcc tggtgaagga gaaggccaca ggccgctact acgccatgaa    960

gatcctcaag aaggaagtca tcgtggccaa ggacgaggtg gcccacacac tcaccgagaa   1020

ccgcgtcctg cagaactcca ggcacccctt cctcacagcc ctgaagtact ctttccagac   1080

ccacgaccgc ctctgctttg tcatggagta cgccaacggg ggcgagctgt tcttccacct   1140

gtcccgggag cgtgtgttct ccgaggaccg ggcccgcttc tatggcgctg agattgtgtc   1200

agccctggac tacctgcact cggagaagaa cgtggtgtac cgggacctca agctggagaa   1260

cctcatgctg gacaaggacg ggcacattaa gatcacagac ttcgggctgt gcaaggaggg   1320

gatcaaggac ggtgccacca tgaagacctt ttgcggcaca cctgagtacc tggcccccga   1380

ggtgctggag gacaatgact acggccgtgc agtggactgg tgggggctgg gcgtggtcat   1440

gtacgagatg atgtgcggtc gcctgccctt ctacaaccag gaccatgaga agctttttga   1500

gctcatcctc atggaggaga tccgcttccc gcgcacgctt ggtcccgagg ccaagtcctt   1560

gctttcaggg ctgctcaaga aggaccccaa gcagaggctt ggcgggggct ccgaggacgc   1620

caaggagatc atgcagcatc gcttctttgc cggtatcgtg tggcagcacg tgtacgagaa   1680

gaagctcagc ccacccttca agccccaggt cacgtcggag actgacacca ggtattttga   1740

tgaggagttc acggcccaga tgatcaccat cacaccacct gaccaagatg acagcatgga   1800

gtgtgtggac agcgagcgca ggccccactt cccccagttc tcctactcgg ccagcggcac   1860

ggcctgaggc ggcggtggac tgcgctggac gatagcttgg agggatggag aggcggcctc   1920

gtgccatgat ctgtatttaa tggtttttat ttctcgggtg catttgagag aagccacgct   1980

gtcctctcga gcccagatgg aaagacgttt ttgtgctgtg ggcagcaccc tcccccgcag   2040

cggggtaggg aagaaaacta tcctgcgggt tttaatttat ttcatccagt ttgttctccg   2100

ggtgtggcct cagccctcag aacaatccga ttcacgtagg gaaatgttaa ggacttctgc   2160

agctatgcgc aatgtggcat tggggggccg ggcaggtcct gcccatgtgt cccctcactc   2220

tgtcagccag ccgccctggg ctgtctgtca ccagctatct gtcatctctc tggggccctg   2280

ggcctcagtt caacctggtg gcaccagatg caacctcact atggtatgct ggccagcacc   2340

ctctcctggg ggtggcaggc acacagcagc cccccagcac taaggccgtg tctctgagga   2400

cgtcatcgga ggctgggccc ctgggatggg accagggatg ggggatgggc cagggtttac   2460

ccagtgggac agaggagcaa ggtttaaatt tgttattgtg tattatgttg ttcaaatgca   2520

ttttgggggt ttttaatctt tgtgacagga aagccctccc ccttcccctt ctgtgtcaca   2580

gttcttggtg actgtcccac cgggagcctc cccctcagat gatctctcca cggtagcact   2640

tgaccttttc gacgcttaac ctttccgctg tcgccccagg ccctccctga ctccctgtgg   2700

gggtggccat ccctgggccc ctccacgcct cctggccaga cgctgccgct gccgctgcac   2760

cacggcgttt ttttacaaca ttcaacttta gtatttttac tattataata taatatggaa   2820

ccttccctcc aaattcttca ataaaagttg cttttcaaaa aaaaaaaaaa aaaaaaaa     2878


<210>  1016
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  1016

Met Ser Asp Val Ala Ile Val Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15


Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp 
            20                  25                  30


Gly Thr Phe Ile Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg 
        35                  40                  45


Glu Ala Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys 
    50                  55                  60


Thr Glu Arg Pro Arg Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80


Thr Thr Val Ile Glu Arg Thr Phe His Val Glu Thr Pro Glu Glu Arg 
                85                  90                  95


Glu Glu Trp Thr Thr Ala Ile Gln Thr Val Ala Asp Gly Leu Lys Lys 
            100                 105                 110


Gln Glu Glu Glu Glu Met Asp Phe Arg Ser Gly Ser Pro Ser Asp Asn 
        115                 120                 125


Ser Gly Ala Glu Glu Met Glu Val Ser Leu Ala Lys Pro Lys His Arg 
    130                 135                 140


Val Thr Met Asn Glu Phe Glu Tyr Leu Lys Leu Leu Gly Lys Gly Thr 
145                 150                 155                 160


Phe Gly Lys Val Ile Leu Val Lys Glu Lys Ala Thr Gly Arg Tyr Tyr 
                165                 170                 175


Ala Met Lys Ile Leu Lys Lys Glu Val Ile Val Ala Lys Asp Glu Val 
            180                 185                 190


Ala His Thr Leu Thr Glu Asn Arg Val Leu Gln Asn Ser Arg His Pro 
        195                 200                 205


Phe Leu Thr Ala Leu Lys Tyr Ser Phe Gln Thr His Asp Arg Leu Cys 
    210                 215                 220


Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His Leu Ser 
225                 230                 235                 240


Arg Glu Arg Val Phe Ser Glu Asp Arg Ala Arg Phe Tyr Gly Ala Glu 
                245                 250                 255


Ile Val Ser Ala Leu Asp Tyr Leu His Ser Glu Lys Asn Val Val Tyr 
            260                 265                 270


Arg Asp Leu Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile 
        275                 280                 285


Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala 
    290                 295                 300


Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val 
305                 310                 315                 320


Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly 
                325                 330                 335


Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln 
            340                 345                 350


Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg Phe 
        355                 360                 365


Pro Arg Thr Leu Gly Pro Glu Ala Lys Ser Leu Leu Ser Gly Leu Leu 
    370                 375                 380


Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Ser Glu Asp Ala Lys 
385                 390                 395                 400


Glu Ile Met Gln His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val 
                405                 410                 415


Tyr Glu Lys Lys Leu Ser Pro Pro Phe Lys Pro Gln Val Thr Ser Glu 
            420                 425                 430


Thr Asp Thr Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Met Ile Thr 
        435                 440                 445


Ile Thr Pro Pro Asp Gln Asp Asp Ser Met Glu Cys Val Asp Ser Glu 
    450                 455                 460


Arg Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Thr Ala 
465                 470                 475                 480


<210>  1017
<211>  3008
<212>  DNA
<213>  Homo sapiens

<400>  1017
taattatggg tctgtaacca ccctggactg ggtgctcctc actgacggac ttgtctgaac     60

ctctctttgt ctccagcgcc cagcactggg cctggcaaaa cctgagacgc ccggtacatg    120

ttggccaaat gaatgaacca gattcagacc ggcaggggcg ctgtggttta ggaggggcct    180

ggggtttctc ccaggaggtt tttgggcttg cgctggaggg ctctggactc ccgtttgcgc    240

cagtggcctg catcctggtc ctgtcttcct catgtttgaa tttctttgct ttcctagtct    300

ggggagcagg gaggagccct gtgccctgtc ccaggatcca tgggtaggaa caccatggac    360

agggagagca aacggggcca tctgtcacca ggggcttagg gaaggccgag ccagcctggg    420

tcaaagaagt caaaggggct gcctggagga ggcagcctgt cagctggtgc atcagaggct    480

gtggccaggc cagctgggct cggggagcgc cagcctgaga ggagcgcgtg agcgtcgcgg    540

gagcctcggg caccatgagc gacgtggcta ttgtgaagga gggttggctg cacaaacgag    600

gggagtacat caagacctgg cggccacgct acttcctcct caagaatgat ggcaccttca    660

ttggctacaa ggagcggccg caggatgtgg accaacgtga ggctcccctc aacaacttct    720

ctgtggcgca gtgccagctg atgaagacgg agcggccccg gcccaacacc ttcatcatcc    780

gctgcctgca gtggaccact gtcatcgaac gcaccttcca tgtggagact cctgaggagc    840

gggaggagtg gacaaccgcc atccagactg tggctgacgg cctcaagaag caggaggagg    900

aggagatgga cttccggtcg ggctcaccca gtgacaactc aggggctgaa gagatggagg    960

tgtccctggc caagcccaag caccgcgtga ccatgaacga gtttgagtac ctgaagctgc   1020

tgggcaaggg cactttcggc aaggtgatcc tggtgaagga gaaggccaca ggccgctact   1080

acgccatgaa gatcctcaag aaggaagtca tcgtggccaa ggacgaggtg gcccacacac   1140

tcaccgagaa ccgcgtcctg cagaactcca ggcacccctt cctcacagcc ctgaagtact   1200

ctttccagac ccacgaccgc ctctgctttg tcatggagta cgccaacggg ggcgagctgt   1260

tcttccacct gtcccgggag cgtgtgttct ccgaggaccg ggcccgcttc tatggcgctg   1320

agattgtgtc agccctggac tacctgcact cggagaagaa cgtggtgtac cgggacctca   1380

agctggagaa cctcatgctg gacaaggacg ggcacattaa gatcacagac ttcgggctgt   1440

gcaaggaggg gatcaaggac ggtgccacca tgaagacctt ttgcggcaca cctgagtacc   1500

tggcccccga ggtgctggag gacaatgact acggccgtgc agtggactgg tgggggctgg   1560

gcgtggtcat gtacgagatg atgtgcggtc gcctgccctt ctacaaccag gaccatgaga   1620

agctttttga gctcatcctc atggaggaga tccgcttccc gcgcacgctt ggtcccgagg   1680

ccaagtcctt gctttcaggg ctgctcaaga aggaccccaa gcagaggctt ggcgggggct   1740

ccgaggacgc caaggagatc atgcagcatc gcttctttgc cggtatcgtg tggcagcacg   1800

tgtacgagaa gaagctcagc ccacccttca agccccaggt cacgtcggag actgacacca   1860

ggtattttga tgaggagttc acggcccaga tgatcaccat cacaccacct gaccaagatg   1920

acagcatgga gtgtgtggac agcgagcgca ggccccactt cccccagttc tcctactcgg   1980

ccagcggcac ggcctgaggc ggcggtggac tgcgctggac gatagcttgg agggatggag   2040

aggcggcctc gtgccatgat ctgtatttaa tggtttttat ttctcgggtg catttgagag   2100

aagccacgct gtcctctcga gcccagatgg aaagacgttt ttgtgctgtg ggcagcaccc   2160

tcccccgcag cggggtaggg aagaaaacta tcctgcgggt tttaatttat ttcatccagt   2220

ttgttctccg ggtgtggcct cagccctcag aacaatccga ttcacgtagg gaaatgttaa   2280

ggacttctgc agctatgcgc aatgtggcat tggggggccg ggcaggtcct gcccatgtgt   2340

cccctcactc tgtcagccag ccgccctggg ctgtctgtca ccagctatct gtcatctctc   2400

tggggccctg ggcctcagtt caacctggtg gcaccagatg caacctcact atggtatgct   2460

ggccagcacc ctctcctggg ggtggcaggc acacagcagc cccccagcac taaggccgtg   2520

tctctgagga cgtcatcgga ggctgggccc ctgggatggg accagggatg ggggatgggc   2580

cagggtttac ccagtgggac agaggagcaa ggtttaaatt tgttattgtg tattatgttg   2640

ttcaaatgca ttttgggggt ttttaatctt tgtgacagga aagccctccc ccttcccctt   2700

ctgtgtcaca gttcttggtg actgtcccac cgggagcctc cccctcagat gatctctcca   2760

cggtagcact tgaccttttc gacgcttaac ctttccgctg tcgccccagg ccctccctga   2820

ctccctgtgg gggtggccat ccctgggccc ctccacgcct cctggccaga cgctgccgct   2880

gccgctgcac cacggcgttt ttttacaaca ttcaacttta gtatttttac tattataata   2940

taatatggaa ccttccctcc aaattcttca ataaaagttg cttttcaaaa aaaaaaaaaa   3000

aaaaaaaa                                                            3008


<210>  1018
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  1018

Met Ser Asp Val Ala Ile Val Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15


Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp 
            20                  25                  30


Gly Thr Phe Ile Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg 
        35                  40                  45


Glu Ala Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys 
    50                  55                  60


Thr Glu Arg Pro Arg Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80


Thr Thr Val Ile Glu Arg Thr Phe His Val Glu Thr Pro Glu Glu Arg 
                85                  90                  95


Glu Glu Trp Thr Thr Ala Ile Gln Thr Val Ala Asp Gly Leu Lys Lys 
            100                 105                 110


Gln Glu Glu Glu Glu Met Asp Phe Arg Ser Gly Ser Pro Ser Asp Asn 
        115                 120                 125


Ser Gly Ala Glu Glu Met Glu Val Ser Leu Ala Lys Pro Lys His Arg 
    130                 135                 140


Val Thr Met Asn Glu Phe Glu Tyr Leu Lys Leu Leu Gly Lys Gly Thr 
145                 150                 155                 160


Phe Gly Lys Val Ile Leu Val Lys Glu Lys Ala Thr Gly Arg Tyr Tyr 
                165                 170                 175


Ala Met Lys Ile Leu Lys Lys Glu Val Ile Val Ala Lys Asp Glu Val 
            180                 185                 190


Ala His Thr Leu Thr Glu Asn Arg Val Leu Gln Asn Ser Arg His Pro 
        195                 200                 205


Phe Leu Thr Ala Leu Lys Tyr Ser Phe Gln Thr His Asp Arg Leu Cys 
    210                 215                 220


Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His Leu Ser 
225                 230                 235                 240


Arg Glu Arg Val Phe Ser Glu Asp Arg Ala Arg Phe Tyr Gly Ala Glu 
                245                 250                 255


Ile Val Ser Ala Leu Asp Tyr Leu His Ser Glu Lys Asn Val Val Tyr 
            260                 265                 270


Arg Asp Leu Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile 
        275                 280                 285


Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala 
    290                 295                 300


Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val 
305                 310                 315                 320


Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly 
                325                 330                 335


Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln 
            340                 345                 350


Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg Phe 
        355                 360                 365


Pro Arg Thr Leu Gly Pro Glu Ala Lys Ser Leu Leu Ser Gly Leu Leu 
    370                 375                 380


Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Ser Glu Asp Ala Lys 
385                 390                 395                 400


Glu Ile Met Gln His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val 
                405                 410                 415


Tyr Glu Lys Lys Leu Ser Pro Pro Phe Lys Pro Gln Val Thr Ser Glu 
            420                 425                 430


Thr Asp Thr Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Met Ile Thr 
        435                 440                 445


Ile Thr Pro Pro Asp Gln Asp Asp Ser Met Glu Cys Val Asp Ser Glu 
    450                 455                 460


Arg Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Thr Ala 
465                 470                 475                 480


<210>  1019
<211>  1038
<212>  DNA
<213>  Homo sapiens

<400>  1019
atggagttcc ctgagcacgg cggacggctg ctgggccgcc tgagacagca gcgcgagctg     60

ggcttcctat gcgactgcac cgtgctggtg ggcgacgcgc gcttcccggc ccaccgtgcc    120

gtgctggccg cgtgcagcgt ctacttccat ctcttctaca gggaccggcc cgcgggcagt    180

cgcgacacgg tgcggctcaa cggcgacatc gtcacggcgc ccgccttcgg ccgcctactg    240

gacttcatgt acgagggccg cctggacctg cgcagcctgc ctgtggagga cgtcctggca    300

gccgccagct acctgcacat gtatgacatc gtcaaggtct gcaagggcag gctccaggag    360

aaggatcgaa gtctggaccc ggggaaccct gcccctgggg cagaacctgc tcagccaccg    420

tgcccctggc ctgtctggac cgcggacctc tgcccagctg cccgaaaggc caagctcccc    480

ccgtttgggg tcaaggctgc cctccctcct cgagcatctg ggcctcctcc ctgccaggtc    540

ccagaagagt cagaccaggc cctggacctg tcgttgaagt ctggcccaag gcaggagcgg    600

gtccacccac cgtgcgtcct ccagacaccc ctctgcagcc agaggcagcc aggggcccag    660

ccactggtga aggacgaacg ggactcactg tccgaacagg aggagagcag cagctctagg    720

agcccccaca gtcccccgaa gccacctcct gttcctgcag ccaagggcct ggtgctgcac    780

ctcagtgccc acttccgtga gcgagacagc acccgggccc ggctctcacc cgacggcgtg    840

gcacccacct gcccgctctg tgggaagacc ttctcgtgca catacacact gaagaggcac    900

gagcggacac actcggtgca cactcgagag aagccgcatg cctgccggtg gtgtgagcgc    960

cgtttcacgc agtccgggga cctctaccgc cacgtccgca agtttcactg tggcctcgtc   1020

aagtcccttc tggtgtga                                                 1038


<210>  1020
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  1020

Met Glu Phe Pro Glu His Gly Gly Arg Leu Leu Gly Arg Leu Arg Gln 
1               5                   10                  15


Gln Arg Glu Leu Gly Phe Leu Cys Asp Cys Thr Val Leu Val Gly Asp 
            20                  25                  30


Ala Arg Phe Pro Ala His Arg Ala Val Leu Ala Ala Cys Ser Val Tyr 
        35                  40                  45


Phe His Leu Phe Tyr Arg Asp Arg Pro Ala Gly Ser Arg Asp Thr Val 
    50                  55                  60


Arg Leu Asn Gly Asp Ile Val Thr Ala Pro Ala Phe Gly Arg Leu Leu 
65                  70                  75                  80


Asp Phe Met Tyr Glu Gly Arg Leu Asp Leu Arg Ser Leu Pro Val Glu 
                85                  90                  95


Asp Val Leu Ala Ala Ala Ser Tyr Leu His Met Tyr Asp Ile Val Lys 
            100                 105                 110


Val Cys Lys Gly Arg Leu Gln Glu Lys Asp Arg Ser Leu Asp Pro Gly 
        115                 120                 125


Asn Pro Ala Pro Gly Ala Glu Pro Ala Gln Pro Pro Cys Pro Trp Pro 
    130                 135                 140


Val Trp Thr Ala Asp Leu Cys Pro Ala Ala Arg Lys Ala Lys Leu Pro 
145                 150                 155                 160


Pro Phe Gly Val Lys Ala Ala Leu Pro Pro Arg Ala Ser Gly Pro Pro 
                165                 170                 175


Pro Cys Gln Val Pro Glu Glu Ser Asp Gln Ala Leu Asp Leu Ser Leu 
            180                 185                 190


Lys Ser Gly Pro Arg Gln Glu Arg Val His Pro Pro Cys Val Leu Gln 
        195                 200                 205


Thr Pro Leu Cys Ser Gln Arg Gln Pro Gly Ala Gln Pro Leu Val Lys 
    210                 215                 220


Asp Glu Arg Asp Ser Leu Ser Glu Gln Glu Glu Ser Ser Ser Ser Arg 
225                 230                 235                 240


Ser Pro His Ser Pro Pro Lys Pro Pro Pro Val Pro Ala Ala Lys Gly 
                245                 250                 255


Leu Val Leu His Leu Ser Ala His Phe Arg Glu Arg Asp Ser Thr Arg 
            260                 265                 270


Ala Arg Leu Ser Pro Asp Gly Val Ala Pro Thr Cys Pro Leu Cys Gly 
        275                 280                 285


Lys Thr Phe Ser Cys Thr Tyr Thr Leu Lys Arg His Glu Arg Thr His 
    290                 295                 300


Ser Val His Thr Arg Glu Lys Pro His Ala Cys Arg Trp Cys Glu Arg 
305                 310                 315                 320


Arg Phe Thr Gln Ser Gly Asp Leu Tyr Arg His Val Arg Lys Phe His 
                325                 330                 335


Cys Gly Leu Val Lys Ser Leu Leu Val 
            340                 345


<210>  1021
<211>  6568
<212>  DNA
<213>  Homo sapiens

<400>  1021
gctcggcccg ggctgccacg agcgtgcggg cctcgccggg catgtcctag gcggcggccc     60

cgcccagcgc tcggccgggc gggcgggcgg gcgcgagggc agggaccgag ccgggccgag    120

ctggggaaca agccggggac caagccgggg accaagccgg ggactaaggc gagccggaga    180

ccgagcccga acagcagtcc cgcagcgtgg acaagcagca tgccgtcatc aactacgacc    240

aggacaggga cgagcactgg gtgaaggacc tgggcagcct caatgggacg tttgtgaatg    300

acatgcgcat cccggaccag aagtacgtca cgctgaagct caacgatgtc atccgcttcg    360

gctacgattc caacatgtat gtgctggagc gtgtgcagca ccgagtcccg gaggaggcac    420

tcaagcatga aaagtacacc agccagctgc aggtgagcgt gaagggtttg gcgcccaaga    480

ggagcgaggc actgccggaa cacacaccat actgcgaggc ctcgaacccc aggccggaga    540

agggggaccg gagaccagga acagaggcag cctcttaccg cacacccctg tatgggcagc    600

cctcctggtg gggtgaggac gatggtagca cgctgcctga cgcccagcgc cagggagagc    660

cctacccaga gcgccccaag ggaccagtgc agcaggacgg ggagctccac ggcttccgcg    720

cccctgctga gcctcagggc tgctcgttcc ggcgggagcc cagctacttc gagatcccca    780

cgaaggagac cccgcagccg tcgcagcccc ccgaggtgcc ggcacacgag atgcccacga    840

aggatgcaga ggcaggtggg ggcggagcgg cccctgtggt gcagagccac gcctccttca    900

ccatcgagtt tgatgactgc agccctggca agatgaagat caaggaccat atcaccaagt    960

tttccctgcg ccagcggcgg cccccgggca aggaggccac acctggcgag atggtgtcgg   1020

ctgagaccaa ggtggccgac tggctggtgc agaatgaccc gagcctgctg caccgggttg   1080

gccctgggga tgaccgccac agcaccaaga gcgacctgcc tgtccacacc cgcaccctga   1140

agggccacaa gcacgaggac ggcacgcaga gtgactcaga ggaccccctg gccaaggcgg   1200

cctcggccgc tggggtgccc ttggaggcca gcggggagca ggtgcggctg cagaggcaga   1260

tcaagcggga cccccaggag ctactacata accagcaggc ctttgtcatc gagttcttcg   1320

acgaggacac accccgaaag aagcgctccc agtccttcac gcacagcccg tccggggacc   1380

ccaaggccga caagcgccgt ggcccaacgc cggccgatag ggaccgcccc agtgtcccag   1440

ccccagtcca ggcagggggc cgcagctcgg ggccacagag ggccggctcg ctcaagcggg   1500

agaagacaga ggaacggctg ggcagcccct cgcccgcctc ccgaacccct gcccgcccct   1560

tcggaagcgt ggggcgccgc tcccgcctgg cccaggactt catggcccag tgtctgcggg   1620

agagctcccc ggccgcccgg cccagccccg agaaggttcc tccggtgctg cccgctcccc   1680

tgacacccca tgggaccagc cccgtgggcc ccccgacccc accgcccgcc cccacggacc   1740

cccagctgac caaggcacgg aaacaggagg aggacgacag cctcagtgac gcagggacat   1800

acaccatcga gaccgaggcg caggacacgg aggtggagga ggcccggaag atgatcgacc   1860

aggtctttgg ggtgttggag tcccctgaac tctccagggc atcttcggcc acctttcgcc   1920

cagtcatcag aggggacaga gatgagtctg atgacggggg cgtggcccag cggatggcgc   1980

tactgcagga gtttgcctcc cggccactgg gtgcggcccc ccaggcggag caccagggcc   2040

tcccggtgcc gggctcccct gggggtcaga agtgggtgtc ccgctgggcc agcctggctg   2100

acagctactc agacccgggc ctcacagagg atggcctggg acgtagaggc ggggagccgg   2160

aggggtccct gcctgtgcgc atgcggcgac ggctccctca gctgcccagt gagagggctg   2220

acagccctgc gggcccagag agcagcagga ggagtgggcc tgggccaccg gagctggaca   2280

gtgagcagcc cagccgcctc ttcggccagg aggagttgga tcctgacagc ctcagcgatg   2340

ccagtgggtc ggacgggggc cgaggccccg agccaggggt ggagccacag gacagcagac   2400

gcaggagccc ccaggagggg cccacgtgga gcaggggtcg gcgctcacca agggcccccg   2460

gggagccaac tcccgcctct ttcttcattg gggaccagaa tggggacgct gtgttatcta   2520

ggaaaccgct tgcggctcca ggggatgggg agggcctagg gcagacagcc cagcccagcc   2580

ccccagcacg ggatggcgtc tatgtcagtg ccaatgggag aatggtcatc cagctacggc   2640

ctggacggtc cccagaaccc gacggccctg ccccagcctt tctccggcaa gagagcttca   2700

ctaaggagcc agccagtggt cccccagcgc ccggcaagcc cccccacatc tccagccacc   2760

cgcttctaca ggacctggcc gctacccggg ccgcacgcat ggacttccac tcccaggaca   2820

cccacctgat cttgaaggag acggagacgg ccctggcggc cctggaggcc cgactcctct   2880

ctaattctgt ggatgccgag tgtgaggggg gcagcacccc gaggccgccg gaggacgccc   2940

tgtctgggga ctcggacgtg gacacagcca gcaccgtcag cctgcgtagt ggcaagagcg   3000

ggcccagccc cacaaccccc cagcctctgc gggcacagaa ggagatgtcg ccatccccgc   3060

cagctgcaca ggacccggga ggcaccgccc tggtcagtgc ccgtgagcag tcctcagaga   3120

ggcagcatca cccacttggc ccgacggaca tgggccgtgg agagccggta cggcgctcag   3180

ccataaggcg tggccacagg ccccgagggt ccctggattg gcccagtgag gagcgtggcc   3240

ctgtcctcgc ccacctaccc agctcagatg tgatggcctc caaccacgaa acccctgagg   3300

ccaccggggc aggacggcta ggttctcgcc ggaaaccagc ggccccaccg ccatccccag   3360

ctgcccggga ggagcagagc cgtagctcag ccagctccca gaaggggccg caggccttga   3420

cccgctccaa cagcctgtcc acccctcgcc ccacacgggc ctcccggctg aggcgggccc   3480

ggctggggga cgcttcagac actgaggctg cggatggtga gcgggggtcc ctgggcaacc   3540

ctgagcccgt gggccggcca gctgctgagc aggccaagaa gctgtcacgc ctggacatcc   3600

tggccatgcc ccggaagcgg gccggctcct tcacagggac tagtgacccc gaggcagccc   3660

ctgcccgcac cagcttctct ggccgcagtg tggagttgtg ctgtgccagc cgcaagccca   3720

ccatggccga agcacgggct gtctccagga aggctgccaa cacagccacc accacgggtc   3780

cccgccagcc cttcagcagg gcccgctcag gcagtgcccg atacacctcc accactcaga   3840

ccccgagggc tggcagctcc agccgggctc gttcccgggc ccccggcccc cgggacacgg   3900

acgacgatga ggaggagcct gacccttatg gtttcatcgt gcagacggca gagattgcgg   3960

agattgccag gctgagccag acgctggtga aggacgtggc catcctagcc caggagatcc   4020

acgatgtggc tggggacggt gacacactgg gctcctcgga gcctgcccac agcgcctccc   4080

tcagcaacat gcccagcacc cccgcctcga ccatctctgc ccgggaggag ctggtgcagc   4140

gcatccccga ggccagcctc aacttccaga aggtgccgcc cggctcgctg aactctcggg   4200

actttgacca gaacatgaac gacagctgtg aggacgccct ggccaacaag acgcggcctc   4260

ggaaccgaga ggaggtgatc ttcgataacc tgatgctgaa cccggtgtcc cagctgtcgc   4320

aggccatccg tgagaacaca gagcaccttg ccgagaagat gaagatcctc tttcagaaca   4380

cagggagagc ttgggaggac ctggaagcca ggatcaacgc cgagaacgag gtgcccatcc   4440

tgaagacatc taacaaggaa atcagctcca tcctgaagga actgaggcgg gtgcagaaac   4500

agctggaagt tatcaatgcc atcgtggacc ccagtgggag cctggacctg ctcacaggaa   4560

acaggagctt ggccagctct gcacagccgg ggctggggaa gggccgcgtg gctgcccaga   4620

gcccaccctc acccgcctca gccgaggccc tgctgccagc cctgcccctg aggaatttcc   4680

cacagcgggc cagctgtggg cctcccagcc tcccggaccc caccttcctc cctgatgccg   4740

agaggttcct gatctaggcc ccagacctgg ccaggccagc ctccctgtgc gtgtgcgtct   4800

ctgccttccg tccgccgcac acccgcctgc ctggccgcag gtggttctcc ctgaagaccc   4860

ccacatgtgc catatccctg tgggcgggtg cctcccacgc ccttgccccc tcgtcagctc   4920

ccagccagca ccctactcac cctgtccagc cccatggcca cccccacccc tgcctcgccc   4980

cctacaggcc tctgggccca gctcctggcc aggctgctgc caaggtcaag ccctcaaggg   5040

cattaccccg cctcctcttc atcactgtta tttttgtctt tagctttaaa ggaaagagtt   5100

gttggtgcca ttgcaggtgc cccctccagg cctgactggc tccgccaggc actaacctgc   5160

cataaccctt tgtgctggcc tgcggccagg cagaggaaga gaggtcgact gtggggtcat   5220

ttggtgccaa acatggaggt gggcaggctc acctgttcct gggactgtct gagatggcag   5280

ggcacttgcc ctggtggctc ccacctgacc ccaggccttt tataggcagg agccccactg   5340

cttccagcct ctggtgccaa cacagttgcc aaacccattg agcttggggc tgccctgtgg   5400

aggcctcctg ggtatggacc aggggcttgt tgagagctga gccatgcaca caggtgcaga   5460

caccccccaa ctcccatgca cacggctagt ccaggcgcct ccacgctgca ccgtgaggac   5520

tgcagggcat gtccccgtga ggggctatgg gcctctgtag gtgggcttcc aaggtcctgg   5580

gtgcagccgg gtgcatggca gcccttctgg cgggggtgag cgcacgacca aagtcactgg   5640

aagccgggtt tccggaagct cgcagcttgg cctgcaccac acgccctccc cttttggctt   5700

cacgccatca ggcctcaagt gggcatgggg gcagggacgg gcccaggaac tgttgttttc   5760

tcaggattct ttcagctggg aacatggcag gtgagcagag cttggtgcct ctgccgtggc   5820

ccctgctggg gcagcccgtg ttgccggagc ctctaagcca aagagcccgt tggccgtggt   5880

tggtgggggt ggacgtgggg gtgtcccacc tggaccagac tggcgtgggt gagctccaca   5940

ccctgcctgg caatggtatg agagtcggac ctggacaggg ccagctgctg ggggagcggc   6000

actggggact ggaggctgga agcgggtggt gtgtgtcccc tgtttacttt tagctgagct   6060

ggggttgggt gtacgggttc tgttcctctg agcctgcggc ccacctgatg tttacgtgtg   6120

tgtgtgaggg ggggcggggg tggcaggtgt ccccccctgg tccccgcccc aagagcctgc   6180

tgtctgtatg gaggaggtgc tagcccggtc caccgggctg ctgcccaccc ctgcatgccc   6240

cagttgccca ccccgcctgc ccctggacat gaagtggtca cgcttcatcc acggctcctt   6300

cccacccctc ggcagtggct gtgcaatgtt ttaagttcac aagttcctgc tcctccccac   6360

actgagctcc tttgttcctc cccctccagc ctttgcctgg gaactggtcc ttgtttgccg   6420

ggcttctcgg agggttcact gtacattcgt tctcaggtgg tcttgtggct gtctttcgga   6480

aaatggttat tttatatgat ttgtcatgga atttgttcta ataaatcatt cttctatcac   6540

atggcagcaa aaaaaaaaaa aaaaaaaa                                      6568


<210>  1022
<211>  1484
<212>  PRT
<213>  Homo sapiens

<400>  1022

Met Arg Ile Pro Asp Gln Lys Tyr Val Thr Leu Lys Leu Asn Asp Val 
1               5                   10                  15


Ile Arg Phe Gly Tyr Asp Ser Asn Met Tyr Val Leu Glu Arg Val Gln 
            20                  25                  30


His Arg Val Pro Glu Glu Ala Leu Lys His Glu Lys Tyr Thr Ser Gln 
        35                  40                  45


Leu Gln Val Ser Val Lys Gly Leu Ala Pro Lys Arg Ser Glu Ala Leu 
    50                  55                  60


Pro Glu His Thr Pro Tyr Cys Glu Ala Ser Asn Pro Arg Pro Glu Lys 
65                  70                  75                  80


Gly Asp Arg Arg Pro Gly Thr Glu Ala Ala Ser Tyr Arg Thr Pro Leu 
                85                  90                  95


Tyr Gly Gln Pro Ser Trp Trp Gly Glu Asp Asp Gly Ser Thr Leu Pro 
            100                 105                 110


Asp Ala Gln Arg Gln Gly Glu Pro Tyr Pro Glu Arg Pro Lys Gly Pro 
        115                 120                 125


Val Gln Gln Asp Gly Glu Leu His Gly Phe Arg Ala Pro Ala Glu Pro 
    130                 135                 140


Gln Gly Cys Ser Phe Arg Arg Glu Pro Ser Tyr Phe Glu Ile Pro Thr 
145                 150                 155                 160


Lys Glu Thr Pro Gln Pro Ser Gln Pro Pro Glu Val Pro Ala His Glu 
                165                 170                 175


Met Pro Thr Lys Asp Ala Glu Ala Gly Gly Gly Gly Ala Ala Pro Val 
            180                 185                 190


Val Gln Ser His Ala Ser Phe Thr Ile Glu Phe Asp Asp Cys Ser Pro 
        195                 200                 205


Gly Lys Met Lys Ile Lys Asp His Ile Thr Lys Phe Ser Leu Arg Gln 
    210                 215                 220


Arg Arg Pro Pro Gly Lys Glu Ala Thr Pro Gly Glu Met Val Ser Ala 
225                 230                 235                 240


Glu Thr Lys Val Ala Asp Trp Leu Val Gln Asn Asp Pro Ser Leu Leu 
                245                 250                 255


His Arg Val Gly Pro Gly Asp Asp Arg His Ser Thr Lys Ser Asp Leu 
            260                 265                 270


Pro Val His Thr Arg Thr Leu Lys Gly His Lys His Glu Asp Gly Thr 
        275                 280                 285


Gln Ser Asp Ser Glu Asp Pro Leu Ala Lys Ala Ala Ser Ala Ala Gly 
    290                 295                 300


Val Pro Leu Glu Ala Ser Gly Glu Gln Val Arg Leu Gln Arg Gln Ile 
305                 310                 315                 320


Lys Arg Asp Pro Gln Glu Leu Leu His Asn Gln Gln Ala Phe Val Ile 
                325                 330                 335


Glu Phe Phe Asp Glu Asp Thr Pro Arg Lys Lys Arg Ser Gln Ser Phe 
            340                 345                 350


Thr His Ser Pro Ser Gly Asp Pro Lys Ala Asp Lys Arg Arg Gly Pro 
        355                 360                 365


Thr Pro Ala Asp Arg Asp Arg Pro Ser Val Pro Ala Pro Val Gln Ala 
    370                 375                 380


Gly Gly Arg Ser Ser Gly Pro Gln Arg Ala Gly Ser Leu Lys Arg Glu 
385                 390                 395                 400


Lys Thr Glu Glu Arg Leu Gly Ser Pro Ser Pro Ala Ser Arg Thr Pro 
                405                 410                 415


Ala Arg Pro Phe Gly Ser Val Gly Arg Arg Ser Arg Leu Ala Gln Asp 
            420                 425                 430


Phe Met Ala Gln Cys Leu Arg Glu Ser Ser Pro Ala Ala Arg Pro Ser 
        435                 440                 445


Pro Glu Lys Val Pro Pro Val Leu Pro Ala Pro Leu Thr Pro His Gly 
    450                 455                 460


Thr Ser Pro Val Gly Pro Pro Thr Pro Pro Pro Ala Pro Thr Asp Pro 
465                 470                 475                 480


Gln Leu Thr Lys Ala Arg Lys Gln Glu Glu Asp Asp Ser Leu Ser Asp 
                485                 490                 495


Ala Gly Thr Tyr Thr Ile Glu Thr Glu Ala Gln Asp Thr Glu Val Glu 
            500                 505                 510


Glu Ala Arg Lys Met Ile Asp Gln Val Phe Gly Val Leu Glu Ser Pro 
        515                 520                 525


Glu Leu Ser Arg Ala Ser Ser Ala Thr Phe Arg Pro Val Ile Arg Gly 
    530                 535                 540


Asp Arg Asp Glu Ser Asp Asp Gly Gly Val Ala Gln Arg Met Ala Leu 
545                 550                 555                 560


Leu Gln Glu Phe Ala Ser Arg Pro Leu Gly Ala Ala Pro Gln Ala Glu 
                565                 570                 575


His Gln Gly Leu Pro Val Pro Gly Ser Pro Gly Gly Gln Lys Trp Val 
            580                 585                 590


Ser Arg Trp Ala Ser Leu Ala Asp Ser Tyr Ser Asp Pro Gly Leu Thr 
        595                 600                 605


Glu Asp Gly Leu Gly Arg Arg Gly Gly Glu Pro Glu Gly Ser Leu Pro 
    610                 615                 620


Val Arg Met Arg Arg Arg Leu Pro Gln Leu Pro Ser Glu Arg Ala Asp 
625                 630                 635                 640


Ser Pro Ala Gly Pro Glu Ser Ser Arg Arg Ser Gly Pro Gly Pro Pro 
                645                 650                 655


Glu Leu Asp Ser Glu Gln Pro Ser Arg Leu Phe Gly Gln Glu Glu Leu 
            660                 665                 670


Asp Pro Asp Ser Leu Ser Asp Ala Ser Gly Ser Asp Gly Gly Arg Gly 
        675                 680                 685


Pro Glu Pro Gly Val Glu Pro Gln Asp Ser Arg Arg Arg Ser Pro Gln 
    690                 695                 700


Glu Gly Pro Thr Trp Ser Arg Gly Arg Arg Ser Pro Arg Ala Pro Gly 
705                 710                 715                 720


Glu Pro Thr Pro Ala Ser Phe Phe Ile Gly Asp Gln Asn Gly Asp Ala 
                725                 730                 735


Val Leu Ser Arg Lys Pro Leu Ala Ala Pro Gly Asp Gly Glu Gly Leu 
            740                 745                 750


Gly Gln Thr Ala Gln Pro Ser Pro Pro Ala Arg Asp Gly Val Tyr Val 
        755                 760                 765


Ser Ala Asn Gly Arg Met Val Ile Gln Leu Arg Pro Gly Arg Ser Pro 
    770                 775                 780


Glu Pro Asp Gly Pro Ala Pro Ala Phe Leu Arg Gln Glu Ser Phe Thr 
785                 790                 795                 800


Lys Glu Pro Ala Ser Gly Pro Pro Ala Pro Gly Lys Pro Pro His Ile 
                805                 810                 815


Ser Ser His Pro Leu Leu Gln Asp Leu Ala Ala Thr Arg Ala Ala Arg 
            820                 825                 830


Met Asp Phe His Ser Gln Asp Thr His Leu Ile Leu Lys Glu Thr Glu 
        835                 840                 845


Thr Ala Leu Ala Ala Leu Glu Ala Arg Leu Leu Ser Asn Ser Val Asp 
    850                 855                 860


Ala Glu Cys Glu Gly Gly Ser Thr Pro Arg Pro Pro Glu Asp Ala Leu 
865                 870                 875                 880


Ser Gly Asp Ser Asp Val Asp Thr Ala Ser Thr Val Ser Leu Arg Ser 
                885                 890                 895


Gly Lys Ser Gly Pro Ser Pro Thr Thr Pro Gln Pro Leu Arg Ala Gln 
            900                 905                 910


Lys Glu Met Ser Pro Ser Pro Pro Ala Ala Gln Asp Pro Gly Gly Thr 
        915                 920                 925


Ala Leu Val Ser Ala Arg Glu Gln Ser Ser Glu Arg Gln His His Pro 
    930                 935                 940


Leu Gly Pro Thr Asp Met Gly Arg Gly Glu Pro Val Arg Arg Ser Ala 
945                 950                 955                 960


Ile Arg Arg Gly His Arg Pro Arg Gly Ser Leu Asp Trp Pro Ser Glu 
                965                 970                 975


Glu Arg Gly Pro Val Leu Ala His Leu Pro Ser Ser Asp Val Met Ala 
            980                 985                 990


Ser Asn His Glu Thr Pro Glu Ala Thr Gly Ala Gly Arg Leu Gly Ser 
        995                 1000                1005


Arg Arg Lys Pro Ala Ala Pro Pro Pro Ser Pro Ala Ala Arg Glu Glu 
    1010                1015                1020


Gln Ser Arg Ser Ser Ala Ser Ser Gln Lys Gly Pro Gln Ala Leu Thr 
1025                1030                1035                1040


Arg Ser Asn Ser Leu Ser Thr Pro Arg Pro Thr Arg Ala Ser Arg Leu 
                1045                1050                1055


Arg Arg Ala Arg Leu Gly Asp Ala Ser Asp Thr Glu Ala Ala Asp Gly 
            1060                1065                1070


Glu Arg Gly Ser Leu Gly Asn Pro Glu Pro Val Gly Arg Pro Ala Ala 
        1075                1080                1085


Glu Gln Ala Lys Lys Leu Ser Arg Leu Asp Ile Leu Ala Met Pro Arg 
    1090                1095                1100


Lys Arg Ala Gly Ser Phe Thr Gly Thr Ser Asp Pro Glu Ala Ala Pro 
1105                1110                1115                1120


Ala Arg Thr Ser Phe Ser Gly Arg Ser Val Glu Leu Cys Cys Ala Ser 
                1125                1130                1135


Arg Lys Pro Thr Met Ala Glu Ala Arg Ala Val Ser Arg Lys Ala Ala 
            1140                1145                1150


Asn Thr Ala Thr Thr Thr Gly Pro Arg Gln Pro Phe Ser Arg Ala Arg 
        1155                1160                1165


Ser Gly Ser Ala Arg Tyr Thr Ser Thr Thr Gln Thr Pro Arg Ala Gly 
    1170                1175                1180


Ser Ser Ser Arg Ala Arg Ser Arg Ala Pro Gly Pro Arg Asp Thr Asp 
1185                1190                1195                1200


Asp Asp Glu Glu Glu Pro Asp Pro Tyr Gly Phe Ile Val Gln Thr Ala 
                1205                1210                1215


Glu Ile Ala Glu Ile Ala Arg Leu Ser Gln Thr Leu Val Lys Asp Val 
            1220                1225                1230


Ala Ile Leu Ala Gln Glu Ile His Asp Val Ala Gly Asp Gly Asp Thr 
        1235                1240                1245


Leu Gly Ser Ser Glu Pro Ala His Ser Ala Ser Leu Ser Asn Met Pro 
    1250                1255                1260


Ser Thr Pro Ala Ser Thr Ile Ser Ala Arg Glu Glu Leu Val Gln Arg 
1265                1270                1275                1280


Ile Pro Glu Ala Ser Leu Asn Phe Gln Lys Val Pro Pro Gly Ser Leu 
                1285                1290                1295


Asn Ser Arg Asp Phe Asp Gln Asn Met Asn Asp Ser Cys Glu Asp Ala 
            1300                1305                1310


Leu Ala Asn Lys Thr Arg Pro Arg Asn Arg Glu Glu Val Ile Phe Asp 
        1315                1320                1325


Asn Leu Met Leu Asn Pro Val Ser Gln Leu Ser Gln Ala Ile Arg Glu 
    1330                1335                1340


Asn Thr Glu His Leu Ala Glu Lys Met Lys Ile Leu Phe Gln Asn Thr 
1345                1350                1355                1360


Gly Arg Ala Trp Glu Asp Leu Glu Ala Arg Ile Asn Ala Glu Asn Glu 
                1365                1370                1375


Val Pro Ile Leu Lys Thr Ser Asn Lys Glu Ile Ser Ser Ile Leu Lys 
            1380                1385                1390


Glu Leu Arg Arg Val Gln Lys Gln Leu Glu Val Ile Asn Ala Ile Val 
        1395                1400                1405


Asp Pro Ser Gly Ser Leu Asp Leu Leu Thr Gly Asn Arg Ser Leu Ala 
    1410                1415                1420


Ser Ser Ala Gln Pro Gly Leu Gly Lys Gly Arg Val Ala Ala Gln Ser 
1425                1430                1435                1440


Pro Pro Ser Pro Ala Ser Ala Glu Ala Leu Leu Pro Ala Leu Pro Leu 
                1445                1450                1455


Arg Asn Phe Pro Gln Arg Ala Ser Cys Gly Pro Pro Ser Leu Pro Asp 
            1460                1465                1470


Pro Thr Phe Leu Pro Asp Ala Glu Arg Phe Leu Ile 
        1475                1480


<210>  1023
<211>  15563
<212>  DNA
<213>  Homo sapiens

<400>  1023
cgcacgccga gcggctgccg ggggaagcag aggcgccgga ggctggggca ccgccgacgc     60

ctcgggagcc atggccgaag ggggagaagg aggcgaggac gagatccagt ttctgaggac    120

tgaggatgaa gtggtactcc agtgcatcgc caccattcat aaggagcaga ggaagttctg    180

cctggcagcc gagggacttg ggaatcgcct gtgcttcttg gaacccactt cagaagccaa    240

gtacattcct ccagatctct gcgtctgcaa ttttgtgctg gaacagtccc tatctgtcag    300

agccctgcag gaaatgcttg ccaacacagg tgaaaatggc ggcgaagggg cagcacaagg    360

aggtggccac aggaccctgt tatacggcca tgcagttctc ctgaggcact ctttcagcgg    420

aatgtatcta acatgcttga ctacatcaag atcccagaca gacaaacttg cctttgatgt    480

aggtctacgg gaacatgcca caggagaagc ctgttggtgg actatacatc ctgcttccaa    540

acagaggtcc gaaggagaga aagttcgaat tggcgatgac ctcatcctcg tcagcgtgtc    600

ctctgaaaga taccttcatc tctcagtatc aaatggtaac atacaagtgg atgcctcctt    660

tatgcaaaca ctctggaatg tacatcctac gtgctcagga agtagcatcg aagaaggata    720

cctacttggt gggcatgtag tacgtctttt ccatggtcat gatgaatgtt tgacgatacc    780

atctacagac cagaatgatt cccagcacag gaggatattc tacgaagctg ggggagctgg    840

gactcgagcc aggtctcttt ggagagtgga accccttcgg ataagctgga gtggcagtaa    900

catcagatgg ggccaggctt tccgactccg gcatctcacc acaggccact acctggcctt    960

gacagaagac caaggcctta tactgcaaga ccgggcaaag tcagacacca agtccacagc   1020

tttctctttc cgggcatcaa aggaactcaa ggagaaatta gactccagtc acaagcgaga   1080

catagaaggc atgggagttc cagaaatcaa gtatggagat tctgtctgct ttgtgcagca   1140

tatagccagt ggtctgtggg tgacctacaa agcacaagac gccaaaactt cccgcctggg   1200

acctctaaaa agaaaggtca tactccatca ggaaggccac atggatgatg gattaacact   1260

gcagagatgc cagcgtgagg agtcccaggc tgctcggatc atccggaaca ctacagcctt   1320

attcagccag tttgtcagcg gaaacaatcg cacagctgcc cccatcaccc tgcctataga   1380

agaagtcctg cagaccctac aggacttgat cgcctacttc cagcccccag aggaggagat   1440

gcgacatgaa gacaagcaga acaagctccg ctcactcaaa aacagacaaa atcttttcaa   1500

ggaagaggga atgttggccc ttgtcttaaa ttgcattgac cgcttaaatg tctacaatag   1560

cgtagcacac tttgcaggga ttgcaaggga agagagtggc atggcctgga aagaaattct   1620

gaacctcctc tacaaattgc tggctgctct cattcgcgga aacagaaaca attgcgctca   1680

attctccaat aaccttgatt ggctcatcag taaattggac agactagaat cttcctcagg   1740

tatcttggaa gttttgcact gcatcttaac tgaaagccca gaagccttaa atctgatagc   1800

ggagggccac atcaagtcga tcatctccct gttggataag cacgggcgga atcacaaggt   1860

tctggatatc ctgtgctccc tctgtctctg caatggggtt gcagtgagag ccaaccagaa   1920

tctgatctgt gacaacttgc tgccccggag aaacctactc ctgcagacac gactgattaa   1980

cgatgtaacc agtatccggc caaacatctt cctgggagtc gcggagggct cagcccagta   2040

caagaagtgg tacttcgagc tgattatcga ccaggtggac cccttcctaa cagcagagcc   2100

cacacatctg cgggtgggct gggcctcttc ttcaggctat gccccatacc caggaggtgg   2160

agaaggatgg ggaggcaatg gtgttggtga cgacctgtac tcctatggct ttgatggact   2220

tcacctttgg tcaggccgga tacccagagc tgtggcttcc atcaaccagc acctcctgag   2280

atcggatgac gtggtaagct gctgcctgga cctcggggtg cccagcatct cattccgcat   2340

caatgggcag cccgtgcagg ggatgtttga gaacttcaac acagacgggc tcttcttccc   2400

tgtgatgagc ttttcagcag gtgtcaaagt acgtttcctg atgggtggac gtcatggaga   2460

gtttaagttc ctgcctccct ctggctatgc cccttgctat gaagccttac ttccaaaaga   2520

gaagatgaga ttggagcctg tcaaagaata taaacgtgat gctgatggca ttagagatct   2580

cttgggtacc acccagttcc tctcccaagc ctctttcatc ccatgccccg tagacaccag   2640

tcaggttatt ttgccacctc acctagaaaa gatccgagac agactagctg aaaacatcca   2700

tgagctttgg ggaatgaata aaatagaact tggctggact ttcggcaaga tacgagatga   2760

caataaaaga caacaccctt gccttgtgga gttttcaaag ctcccagaaa ctgagaagaa   2820

ctataacctg caaatgtcaa ctgaaacctt aaaaaccctc ttggccctgg ggtgccacat   2880

tgctcatgtt aacccagctg ctgaggagga tctcaagaag gtcaaactgc ccaaaaacta   2940

tatgatgtcc aacggctata agccagcccc tttggatttg tctgatgtga agctgttacc   3000

tcctcaagaa attttagtgg ataagcttgc agaaaatgca cacaatgttt gggcaaaaga   3060

cagaataaaa caaggatgga cctatggcat ccaacaggat ttgaagaaca aaagaaatcc   3120

ccgtctggtg ccatatgcat tactggatga gcgtaccaag aagtcaaaca gggacagcct   3180

gcgggaagct gtgcgcactt ttgttggtta cgggtataac attgagccat cagaccaaga   3240

actagctgac tcggctgtgg agaaggtcag catagacaag atccgatttt tccgggtaga   3300

gcgatcttat gcagtgagat ctggaaagtg gtattttgag tttgaagtgg tgactggagg   3360

agacatgcga gtcggctggg cgaggccagg ctgtcgacct gatgtcgagc tgggggccga   3420

tgaccaagcc tttgtgtttg aaggcaacag gggccagcgt tggcatcaag gaagtgggta   3480

ttttgggcgt acctggcagc caggggatgt ggtcggatgt atgattaacc tggatgatgc   3540

ttcaatgatc ttcacactga atggggagct gctgatcacc aacaaaggct ctgaacttgc   3600

cttcgctgac tacgagattg agaatggctt cgtgcccatc tgctgtctgg gtctatctca   3660

gatcggccgc atgaatctcg ggacagatgc cagtaccttc aagttttata ccatgtgcgg   3720

tctccaagag ggctttgagc cttttgctgt caacatgaac agagatgttg ctatgtggtt   3780

cagcaagcgc ctcccgacgt ttgtcaacgt gccaaaggat catccacaca tagaggtcat   3840

gaggattgat ggcaccatgg acagccctcc gtgtctcaag gtgacgcata agacatttgg   3900

cacacagaat agcaatgccg acatgatcta ttgccgcttg agcatgcctg tcgagtgcca   3960

ctcctccttc agccacagcc cctgtctgga cagtgaagct ttccagaaaa ggaaacagat   4020

gcaagaaata ctctctcata caacaacaca gtgctactac gccatccgca tctttgctgg   4080

acaggatcca tcctgtgtct gggtcggatg ggtgactcca gactatcact tgtacagtga   4140

aaagtttgac ctgaataaaa actgcacagt gactgtcacc ctaggggatg aaagaggccg   4200

ggtccatgaa agtgtgaaac gcagcaactg ctacatggtc tggggtggag acattgtagc   4260

cagttcccag agatcaaatc ggagcaacgt ggacctggag atcggctgtc tcgtggatct   4320

ggccatgggc atgttgtcct tctcagccaa tggaaaggaa ctgggcacct gctaccaggt   4380

ggagcctaat accaaagtgt ttccagcagt cttcctgcag cctacaagta cttctttgtt   4440

tcagtttgaa cttggaaagc tgaagaacgc aatgcccctg tcagcggcca tattcaggag   4500

tgaagagaag aacccagtcc cacagtgtcc acctcggctg gacgtccaaa ccatccagcc   4560

cgtgctctgg agccgcatgc ccaacagctt cctgaaggtg gagaccgagc gtgtgagcga   4620

gcgccacggc tgggtggtgc agtgcctgga gcccctgcag atgatggcgc tccacatccc   4680

cgaggagaac aggtgtgtgg atatcctgga gctctgtgag caggaggacc tgatgcggtt   4740

ccattaccac acgctgaggc tctacagcgc ggtgtgcgcc ctgggaaaca gccgcgtggc   4800

ctacgccctg tgcagccacg tggacctctc ccagctcttc tatgccattg acaacaagta   4860

cctccccggc ctccttcgat ctggtttcta tgacctgctc atcagcatcc acctggccag   4920

cgccaaggag aggaagctga tgatgaagaa cgagtacatc atccccatta ccagcaccac   4980

caggaatatc cgcctcttcc cggacgagtc caagaggcat ggactgcctg gggtgggcct   5040

gagaacatgt ctcaagcccg ggttcaggtt ctccacccct tgctttgttg tgactggtga   5100

ggatcaccaa aagcagagcc ccgagattcc cttggagagt ctcaggacga aggctctgag   5160

tatgctgaca gaggcagtgc agtgcagcgg ggcccacatc cgagaccctg taggggggtc   5220

tgtggagttc cagtttgtgc ctgtgctgaa actcattgga accctgctgg tcatgggcgt   5280

gtttgatgat gatgatgttc ggcagatcct cctcctgatt gatccctctg tgtttgggga   5340

gcatagtgcg gggacagagg agggagcaga aaaggaggaa gtgacccagg tggaggagaa   5400

ggctgtggag gctggggaga aggccggcaa ggaggctcct gtcaaaggct tgttgcagac   5460

tcgattaccc gaatccgtca agctgcagat gtgtgagctc ctcagctatc tctgcgactg   5520

tgagctgcag caccgagtgg aggccattgt ggcatttggt gacatttatg tctccaagct   5580

gcaggcaaat cagaagttcc gctacaatga gctcatgcag gccctgaaca tgtctgcggc   5640

cctgactgcc cggaagacca aggagttccg ctcaccccca caggagcaga tcaacatgct   5700

gcttaacttt caactgggag agaactgccc ctgcccagag gagattcggg aggagctgta   5760

tgatttccat gaggaccttc tccttcactg tggggttcct ttggaagaag aggaagagga   5820

ggaggaggac acctcctgga caggaaaact ctgtgccttg gtttacaaaa tcaaaggccc   5880

acccaagcca gagaaggagc agccgacgga ggaggaggag agatgcccca caacattgaa   5940

ggaactcatc tcacagacga tgatctgctg ggcccaggag gaccagatcc aggattcaga   6000

gctggtccga atgatgttca acctcctccg gaggcagtat gacagcattg gggagctgct   6060

gcaggcgctg cggaagacct acaccatcag ccacacctct gtaagcgaca ccatcaacct   6120

gctggctgcc ctgggccaaa tccgctccct cctcagtgtc aggatgggca aggaagagga   6180

gttgctcatg atcaatgggc tgggagacat aatgaacaac aaggtgtttt accagcatcc   6240

caacctcatg agagtcctgg gcatgcacga gacggtgatg gaggtgatgg tgaacgtgtt   6300

gggtacagag aaatctcaga ttgcatttcc aaagatggtt gctagctgct gccgtttcct   6360

ttgctatttc tgtcgaatta gccggcaaaa tcagaaggcc atgtttgagc atctgagtta   6420

tcttctggag aatagcagtg ttggcctagc ctccccgtcg atgaggggat ccaccccgct   6480

ggatgtggca gcttcctctg tgatggacaa caatgagtta gcgctgagct tagaggaacc   6540

agacctcgag aaggtggtga cctacttggc aggctgtggc ctacagagct gccccatgct   6600

tctggccaaa ggataccctg atgtcggctg gaaccccatt gaaggggaac gctacctgtc   6660

cttcctgagg tttgctgtct tcgtgaacag tgagagtgtg gaagaaaacg ccagcgttgt   6720

ggtcaagctg ctcatcagac gcccagagtg cttcggcccg gccctgcggg gtgagggggg   6780

aaacgggctc ttggcagcca tgcagggtgc cattaagatc tctgagaacc cagcgctcga   6840

cctcccctct caaggataca aaagagaagt cagcacgggg gacgatgaag aggaagaaga   6900

aatcgtgcat atgggcaatg caattatgtc attttattcg gcccttatag atctactggg   6960

ccgctgtgct cctgaaatgc acctcatcca gacaggaaag ggggaagcca tccgcatcag   7020

gtccatcctg cgctccctgg tccccacaga agacctggtt gggatcatca gcatcccctt   7080

gaaactgccc tccctcaaca aagatgggtc ggtcagtgag ccagatatgg cggccaattt   7140

ctgccctgac cacaaggcac ctatggtgct gttcttggac cgcgtttatg gcattaagga   7200

tcaaactttt ctgctccact tgctggaggt tggattttta cctgacctaa gagcttctgc   7260

ctctctagat acagtttccc taagcaccac agaggctgcg cttgcactaa ataggtatat   7320

atgttctgct gtgctcccgc tcctcacaag atgtgcccct ctctttgccg gaacagaaca   7380

ctgcacctct ctgattgatt ccacactgca gacaatatac aggctatcca agggacgttc   7440

cctcaccaaa gcacaaaggg acactataga agaatgtttg cttgccattt gcaatcactt   7500

gaggccttcc atgttacagc aactcctgcg acgcctcgtt tttgatgtgc cgcaactcaa   7560

tgaatactgc aaaatgcctc tcaagcttct gacgaatcac tatgaacagt gttggaagta   7620

ttactgcctg ccttcaggat gggggagcta cgggctagct gtggaagaag agctgcacct   7680

aacggagaag cttttctggg ggatttttga ctcgctctcc cataagaaat atgacccaga   7740

tcttttccga atggccctgc cttgtctcag tgctatagct ggggccttgc caccagatta   7800

tttagatacc agaatcacag ccacgttgga gaaacagatc tcagtggatg cggatggcaa   7860

ctttgaccca aaacctatta acaccatgaa tttttccttg cctgaaaaat tggaatacat   7920

cgtcaccaag tatgctgagc attcacatga taaatgggcc tgtgacaaga gtcagagtgg   7980

atggaaatat gggatttccc tggatgaaaa tgtgaagacc cacccactga taaggccttt   8040

caagacatta acggagaagg agaaggaaat ttatcgctgg cctgcgcgag agtccctgaa   8100

aaccatgctg gctgtgggct ggactgtgga gaggaccaaa gagggagaag ctttggttca   8160

acagcgggaa aatgagaagc ttcgaagtgt gtcccaggcc aaccagggca acagctacag   8220

tcctgctccc ctcgacctct caaacgttgt gctctccaga gagctccagg gaatggtgga   8280

ggtcgtggct gagaactatc acaatatctg ggccaagaag aagaagctgg agctggagag   8340

caaaggtggt ggcagccacc ctcttctggt accatatgac accttgactg ccaaggaaaa   8400

gttcaaggac cgggagaagg cacaggacct gtttaagttc ctccaagtga atggcatcat   8460

agtttccagg ggtatgaagg atatggagct ggatgcctcc tccatggaga agaggtttgc   8520

ctataagttc ttgaagaaga tcctgaaata cgttgattct gctcaagaat ttattgccca   8580

tttagaagcc attgtcagca gtgggaaaac tgaaaagtct ccccgtgacc aggagatcaa   8640

attctttgcc aaagttctcc tcccgctggt tgaccagtac ttcaccagtc attgcctcta   8700

cttcttgtca tcccctctga agccccttag cagcagcgga tatgcctccc ataaggagaa   8760

agaaatggtg gccggcctgt tctgcaaact tgccgctctc gttagacaca gaatttccct   8820

ctttggtagt gattctacta caatggtgag ctgtcttcac atcttagctc agacacttga   8880

cacaaggact gtcatgaagt caggctcaga gctggtgaag gctgggttac gagcattctt   8940

tgaaaatgct gcagaagatt tggagaagac ttcagaaaac ctgaaacttg ggaagttcac   9000

ccattcccga acgcagatta aaggcgtttc tcagaatatt aactacacta cagtggctct   9060

gctccccatc ctgacgtcca tctttgagca cgtcactcag catcagtttg gaatggatct   9120

actcttgggt gatgtgcaga tttcatgcta ccacatactg tgcagcctct actcccttgg   9180

gacgggaaag aacatttatg ttgaaaggca acgccctgcc cttggagaat gtctggcctc   9240

gctggcagct gccataccag tggcattcct ggagcccacc cttaatcgct acaatccact   9300

ctcggtcttc aacaccaaaa cccccaggga gaggtctatt ctggggatgc cagacacggt   9360

agaagacatg tgtcctgaca tcccccagct ggaaggcctg atgaaggaaa tcaacgacct   9420

ggccgagtca ggggcccggt acacagagat gccccatgtc atcgaggtga tcttacccat   9480

gctctgcaac tacttgtcct actggtggga gcggggtcct gagaacctgc cccccagcac   9540

agggccatgc tgcaccaagg tcacctctga acacctcagt ctcatcctgg gcaacattct   9600

gaaaatcatc aacaacaacc tgggcatcga tgaggcctcc tggatgaagc gcattgcagt   9660

gtatgcacag cccatcatca gcaaagccag gcccgacctg ctgagaagcc acttcatccc   9720

aactctggag aagctgaaga aaaaggctgt caagacggtg caggaggagg agcagttgaa   9780

agccgatggc aaaggggaca cccaggaggc agaactcctc atcctggacg agttcgcggt   9840

cctctgcaga gatctctatg ccttctaccc catgctgatc cgctacgtgg acaacaacag   9900

atctaactgg ctgaaaagtc ctgatgctga ttctgaccag ctcttccgca tggtggcaga   9960

agtcttcatt ctgtggtgta aatctcataa cttcaagaga gaagagcaaa attttgtgat  10020

tcagaatgaa attaataatt tggcattttt aactggagac agcaaaagca agatgtcaaa  10080

agccatgcaa gtaaagtctg gaggacaaga ccaggagcgg aagaagacaa agcggcgggg  10140

agacttgtat tccatccaga cctccctcat cgtggctgca ctcaagaaaa tgctgcccat  10200

tggtttgaat atgtgtactc caggcgacca ggagctgatc tccctcgcaa aatcgcgata  10260

cagccatagg gacacagatg aagaggtcag agaacatctg cggaacaact tgcacttgca  10320

ggaaaagtct gatgacccag ctgtaaaatg gcaactgaac ctctacaagg atgttctgaa  10380

gagtgaagaa cctttcaatc cggaaaagac agtggagcgt gtgcagagaa tttcagcagc  10440

tgtcttccac ctggaacagg tggaacagcc tttgaggtcc aagaaggccg tctggcacaa  10500

actgttatca aagcaacgga aacgggcagt ggtggcctgt ttcaggatgg cccctctcta  10560

caacctgccc aggcaccgct ctattaacct cttcctccat ggctatcaga gattttggat  10620

agaaacagag gagtattcct ttgaagagaa actagtacag gatttggcta aatctccaaa  10680

ggtggaagag gaggaggagg aagagacaga aaaacaacct gacccactac atcagatcat  10740

tctctatttt agccgcaacg ctctcacgga gaggagcaaa ttggaagacg accctttgta  10800

cacctcctat tccagcatga tggccaagag ttgtcaaagt ggtgaggatg aagaagaaga  10860

tgaagacaag gaaaaaacat tcgaagagaa agagatggag aagcaaaaaa ccctctatca  10920

gcaagctcgg ctgcatgagc gtggtgctgc agagatggtc cttcagatga taagcgctag  10980

caaaggtgag atgagcccca tggtggttga gacgctgaag ctggggatcg ccattctgaa  11040

cggaggcaat gctggtgtgc aacagaaaat gctagattac ctaaaggaga aaaaggatgc  11100

tggattcttt caaagccttt ctggtcttat gcagtcttgc agtgtccttg atttgaatgc  11160

atttgagagg cagaataaag ctgaaggcct ggggatggtg actgaagaag gaacactcat  11220

tgttcgggaa cgtggtgaaa aagtactcca gaatgacgag ttcacgcgtg atctctttag  11280

attcctacag ttactttgtg agggacataa cagtgacttt cagaacttcc tgcggactca  11340

gatgggcaac accaccaccg tgaatgtcat catcagcact gtggactacc ttctgcgtct  11400

gcaggaatca atcagtgatt tctactggta ttattcaggg aaggacatca ttgatgaatc  11460

tggacagcac aatttttcca aagctctggc agtcaccaag cagattttca attctcttac  11520

agaatacatc cagggccctt gcattggtaa tcaacagagc ctggctcaca gcaggctgtg  11580

ggacgcagtg gttggcttcc tccatgtctt tgctaatatg cagatgaaac tctctcagga  11640

ttccagtcag atcgagctgc tgaaggaact cttggatctc cttcaggaca tggtggtgat  11700

gcttctgtcc ctcctggaag ggaatgtggt aaatggcacc attggcaagc agatggttga  11760

cacactggta gaatcatcta ccaatgtaga aatgatcttg aaattctttg acatgttctt  11820

gaaacttaaa gacttaacca gctcagacac cttcaaagaa tatgacccag atggtaaagg  11880

aattatctcc aaaaaagaat tccagaaggc catggaaggg caaaaacagt acacgcagtc  11940

agagattgac tttctcctgt cgtgtgcaga agctgatgag aatgacatgt ttaattacgt  12000

tgattttgta gaccggttcc atgagccagc caaggacata gggtttaatg tggctgtgtt  12060

attgacaaat ctttctgaac acatgccaaa cgattcccgc ctgaagtgtc tgttggaccc  12120

agcagaaagt gtgctaaatt acttcgaacc ctacctagga cgcatcgaga tcatgggtgg  12180

ggccaagaag attgagcgtg tttattttga gatcagtgaa tccagtcgca ctcagtggga  12240

gaagccccag gtgaaggaat ctaagcgaca gttcattttt gatgttgtca atgaaggtgg  12300

ggagcaggaa aagatggagc tgtttgtgaa cttctgtgag gacaccatct ttgaaatgca  12360

gttagcatct cagatctctg aatccgattc agctgacagg ccagaagagg aggaagaaga  12420

tgaagattct tcttacgtgt tagaaattgc gggtgaagag gaagaagacg ggtctcttga  12480

gccggcctct gcatttgcta tggcctgtgc ctctgtgaag aggaatgtca ccgacttcct  12540

gaagagagca accctgaaga acctcaggaa gcagtacagg aacgtgaaaa agatgactgc  12600

gaaggagctg gtgaaggtgc tcttctcctt tttctggatg ctgttcgtgg ggctattcca  12660

gttgctcttc accatcctgg gaggaatctt tcagatcctc tggagcacag tgtttggagg  12720

gggcctggta gaaggggcaa agaacatcag agtgaccaag atcctgggtg acatgcctga  12780

cccaacccaa tttggtatcc atgatgacac tatggaggct gagagggcag aggtgatgga  12840

gccaggtatc accactgaac tagtacactt cataaagggg gagaagggag atacagatat  12900

catgtcagac ctctttggac tccacccaaa gaaagagggc agcttaaagc atgggcctga  12960

agtgggtttg ggtgacctct cagaaattat tggcaaggat gaacccccta cattagagag  13020

tactgtacag aagaagagga aagctcaggc agcagaaatg aaagcagcaa atgaagcaga  13080

aggaaaagta gaatccgaga aggcagacat ggaagatgga gagaaggaag acaaagacaa  13140

agaagaggag caagctgagt acctgtggac agaagtgaca aaaaagaaga agcggcggtg  13200

tggtcagaag gttgagaagc cggaagcttt cacagccaat ttctttaaag ggctggaaat  13260

ctatcagacc aagttactgc attacctggc caggaatttc tacaacctga ggttccttgc  13320

tctgtttgta gccttcgcta tcaacttcat cctgcttttt tataaggtca ctgaagaacc  13380

tttagaagaa gagacagagg atgttgcaaa cctatggaat tcctttaatg acgaggaaga  13440

ggaagaagcg atggtattct ttgtccttca ggagagcacc gggtatatgg caccaaccct  13500

gcgtgccctg gccatcatcc ataccatcat ctctctagtc tgtgtggtgg gctactactg  13560

cctgaaggtg cctttggtgg ttttcaaaag ggaaaaagaa atcgccagga agctggagtt  13620

tgatggccta tatatcaccg aacagccatc tgaagatgac atcaaggggc agtgggaccg  13680

cttggtgatc aacacaccat cttttcctaa taactactgg gacaagtttg taaagagaaa  13740

ggtgatcaac aagtatggag atctctacgg agcagaacgc attgctgaac ttctgggttt  13800

ggacaaaaat gctcttgact ttagcccagt agaagagacc aaagcagaag cggcttctct  13860

ggtgtcatgg ctaagttcca tagacatgaa gtaccatatc tggaagcttg gagttgtttt  13920

tactgacaac tcctttctct accttgcctg gtatacaacc atgtcagtcc tgggccacta  13980

caataacttc ttctttgctg ctcacctatt ggacatcgca atgggcttca agacactgag  14040

gaccattctg tcatctgtaa ctcacaatgg caaacagttg gttctgactg tcggtctcct  14100

ggccgtggtg gtttatctct atactgtggt ggctttcaac ttcttccgca agttctacaa  14160

caaaagcgaa gacgatgacg agcccgatat gaagtgcgac gacatgatga cgtgttacct  14220

tttccacatg tacgtgggag tgagagcagg aggtggcatt ggtgatgaaa ttgaagaccc  14280

tgctggtgat ccttatgaaa tgtatcgcat tgtctttgac attacctttt tcttcttcgt  14340

cattgtcatc ttgctggcca tcattcaagg tcttattatt gatgctttcg gagagctaag  14400

agaccagcag gaacaagtac gagaagatat ggagactaaa tgtttcatct gtgggattgg  14460

caatgactac tttgacacaa cccctcatgg ttttgaaaca catacattac aagagcacaa  14520

cttagccaac tacttgttct ttctgatgta tttgattaat aaagatgaaa cagagcacac  14580

gggtcaggaa tcttatgtct ggaagatgta ccaagaaagg tgttgggatt tcttcccagc  14640

cggtgactgc tttcgtaaac aatatgaaga tcagcttgga taaatctgaa tcaaagaagc  14700

gcgacaattc tggacagtca acttcccatg aaataaagtc ccctttttac agttctgcaa  14760

catatctgaa atgtgacatt ttctaaatgc ctcccttaaa aaaaaaactg ctgaaaatct  14820

gtgctatttt gaaattgatt tggctttttg tgcctaatgg acatacactg tgggagagaa  14880

cctgtcaaaa tgtcgaagaa ggaaggcgaa gaatcaagta atctctaggc aaatgccttc  14940

aagttttcca gttctgaggt aactagttca gtttgttggg atggaagcat gaaggaaagg  15000

gctagagaag tatgaaatct cgaatgtgta atacctgaaa atttaaacac ttgaatgtca  15060

tcatggtatc caacttgtga ctcatagggt ctgaactcac tccaaaagat aataactgca  15120

gtctaatttt tcccatggta cttgctagtg actgtatcca gaaaagcttt aagcagttaa  15180

agaaacagaa aaaaaccgac actttgtcga cactgaaata tcgattaagt gccttaaaac  15240

ctctttagac atagctatgc aagtttttta tgtttgtgtt ccagaaggac agttccattc  15300

attagttgtg atcttccgtc ttactttatg aaactgcact tgaaggttat tcatacaagt  15360

ttttttagta acagctgtca gtcaactgct gttattagaa gaaaagtact gtactgaaaa  15420

ttcagaaaaa aaatctcaac cttatgccaa aatggagtaa tgctttatgg tcccttgtaa  15480

gtagtggagc tgctctgttt aggtgaatct cctcaaatac aatgaagtgc ccactgcaat  15540

aaagtaatac gtaccaataa aaa                                          15563


<210>  1024
<211>  4870
<212>  PRT
<213>  Homo sapiens

<400>  1024

Met Ala Glu Gly Gly Glu Gly Gly Glu Asp Glu Ile Gln Phe Leu Arg 
1               5                   10                  15


Thr Glu Asp Glu Val Val Leu Gln Cys Ile Ala Thr Ile His Lys Glu 
            20                  25                  30


Gln Arg Lys Phe Cys Leu Ala Ala Glu Gly Leu Gly Asn Arg Leu Cys 
        35                  40                  45


Phe Leu Glu Pro Thr Ser Glu Ala Lys Tyr Ile Pro Pro Asp Leu Cys 
    50                  55                  60


Val Cys Asn Phe Val Leu Glu Gln Ser Leu Ser Val Arg Ala Leu Gln 
65                  70                  75                  80


Glu Met Leu Ala Asn Thr Gly Glu Asn Gly Gly Glu Gly Ala Ala Gln 
                85                  90                  95


Gly Gly Gly His Arg Thr Leu Leu Tyr Gly His Ala Val Leu Leu Arg 
            100                 105                 110


His Ser Phe Ser Gly Met Tyr Leu Thr Cys Leu Thr Thr Ser Arg Ser 
        115                 120                 125


Gln Thr Asp Lys Leu Ala Phe Asp Val Gly Leu Arg Glu His Ala Thr 
    130                 135                 140


Gly Glu Ala Cys Trp Trp Thr Ile His Pro Ala Ser Lys Gln Arg Ser 
145                 150                 155                 160


Glu Gly Glu Lys Val Arg Ile Gly Asp Asp Leu Ile Leu Val Ser Val 
                165                 170                 175


Ser Ser Glu Arg Tyr Leu His Leu Ser Val Ser Asn Gly Asn Ile Gln 
            180                 185                 190


Val Asp Ala Ser Phe Met Gln Thr Leu Trp Asn Val His Pro Thr Cys 
        195                 200                 205


Ser Gly Ser Ser Ile Glu Glu Gly Tyr Leu Leu Gly Gly His Val Val 
    210                 215                 220


Arg Leu Phe His Gly His Asp Glu Cys Leu Thr Ile Pro Ser Thr Asp 
225                 230                 235                 240


Gln Asn Asp Ser Gln His Arg Arg Ile Phe Tyr Glu Ala Gly Gly Ala 
                245                 250                 255


Gly Thr Arg Ala Arg Ser Leu Trp Arg Val Glu Pro Leu Arg Ile Ser 
            260                 265                 270


Trp Ser Gly Ser Asn Ile Arg Trp Gly Gln Ala Phe Arg Leu Arg His 
        275                 280                 285


Leu Thr Thr Gly His Tyr Leu Ala Leu Thr Glu Asp Gln Gly Leu Ile 
    290                 295                 300


Leu Gln Asp Arg Ala Lys Ser Asp Thr Lys Ser Thr Ala Phe Ser Phe 
305                 310                 315                 320


Arg Ala Ser Lys Glu Leu Lys Glu Lys Leu Asp Ser Ser His Lys Arg 
                325                 330                 335


Asp Ile Glu Gly Met Gly Val Pro Glu Ile Lys Tyr Gly Asp Ser Val 
            340                 345                 350


Cys Phe Val Gln His Ile Ala Ser Gly Leu Trp Val Thr Tyr Lys Ala 
        355                 360                 365


Gln Asp Ala Lys Thr Ser Arg Leu Gly Pro Leu Lys Arg Lys Val Ile 
    370                 375                 380


Leu His Gln Glu Gly His Met Asp Asp Gly Leu Thr Leu Gln Arg Cys 
385                 390                 395                 400


Gln Arg Glu Glu Ser Gln Ala Ala Arg Ile Ile Arg Asn Thr Thr Ala 
                405                 410                 415


Leu Phe Ser Gln Phe Val Ser Gly Asn Asn Arg Thr Ala Ala Pro Ile 
            420                 425                 430


Thr Leu Pro Ile Glu Glu Val Leu Gln Thr Leu Gln Asp Leu Ile Ala 
        435                 440                 445


Tyr Phe Gln Pro Pro Glu Glu Glu Met Arg His Glu Asp Lys Gln Asn 
    450                 455                 460


Lys Leu Arg Ser Leu Lys Asn Arg Gln Asn Leu Phe Lys Glu Glu Gly 
465                 470                 475                 480


Met Leu Ala Leu Val Leu Asn Cys Ile Asp Arg Leu Asn Val Tyr Asn 
                485                 490                 495


Ser Val Ala His Phe Ala Gly Ile Ala Arg Glu Glu Ser Gly Met Ala 
            500                 505                 510


Trp Lys Glu Ile Leu Asn Leu Leu Tyr Lys Leu Leu Ala Ala Leu Ile 
        515                 520                 525


Arg Gly Asn Arg Asn Asn Cys Ala Gln Phe Ser Asn Asn Leu Asp Trp 
    530                 535                 540


Leu Ile Ser Lys Leu Asp Arg Leu Glu Ser Ser Ser Gly Ile Leu Glu 
545                 550                 555                 560


Val Leu His Cys Ile Leu Thr Glu Ser Pro Glu Ala Leu Asn Leu Ile 
                565                 570                 575


Ala Glu Gly His Ile Lys Ser Ile Ile Ser Leu Leu Asp Lys His Gly 
            580                 585                 590


Arg Asn His Lys Val Leu Asp Ile Leu Cys Ser Leu Cys Leu Cys Asn 
        595                 600                 605


Gly Val Ala Val Arg Ala Asn Gln Asn Leu Ile Cys Asp Asn Leu Leu 
    610                 615                 620


Pro Arg Arg Asn Leu Leu Leu Gln Thr Arg Leu Ile Asn Asp Val Thr 
625                 630                 635                 640


Ser Ile Arg Pro Asn Ile Phe Leu Gly Val Ala Glu Gly Ser Ala Gln 
                645                 650                 655


Tyr Lys Lys Trp Tyr Phe Glu Leu Ile Ile Asp Gln Val Asp Pro Phe 
            660                 665                 670


Leu Thr Ala Glu Pro Thr His Leu Arg Val Gly Trp Ala Ser Ser Ser 
        675                 680                 685


Gly Tyr Ala Pro Tyr Pro Gly Gly Gly Glu Gly Trp Gly Gly Asn Gly 
    690                 695                 700


Val Gly Asp Asp Leu Tyr Ser Tyr Gly Phe Asp Gly Leu His Leu Trp 
705                 710                 715                 720


Ser Gly Arg Ile Pro Arg Ala Val Ala Ser Ile Asn Gln His Leu Leu 
                725                 730                 735


Arg Ser Asp Asp Val Val Ser Cys Cys Leu Asp Leu Gly Val Pro Ser 
            740                 745                 750


Ile Ser Phe Arg Ile Asn Gly Gln Pro Val Gln Gly Met Phe Glu Asn 
        755                 760                 765


Phe Asn Thr Asp Gly Leu Phe Phe Pro Val Met Ser Phe Ser Ala Gly 
    770                 775                 780


Val Lys Val Arg Phe Leu Met Gly Gly Arg His Gly Glu Phe Lys Phe 
785                 790                 795                 800


Leu Pro Pro Ser Gly Tyr Ala Pro Cys Tyr Glu Ala Leu Leu Pro Lys 
                805                 810                 815


Glu Lys Met Arg Leu Glu Pro Val Lys Glu Tyr Lys Arg Asp Ala Asp 
            820                 825                 830


Gly Ile Arg Asp Leu Leu Gly Thr Thr Gln Phe Leu Ser Gln Ala Ser 
        835                 840                 845


Phe Ile Pro Cys Pro Val Asp Thr Ser Gln Val Ile Leu Pro Pro His 
    850                 855                 860


Leu Glu Lys Ile Arg Asp Arg Leu Ala Glu Asn Ile His Glu Leu Trp 
865                 870                 875                 880


Gly Met Asn Lys Ile Glu Leu Gly Trp Thr Phe Gly Lys Ile Arg Asp 
                885                 890                 895


Asp Asn Lys Arg Gln His Pro Cys Leu Val Glu Phe Ser Lys Leu Pro 
            900                 905                 910


Glu Thr Glu Lys Asn Tyr Asn Leu Gln Met Ser Thr Glu Thr Leu Lys 
        915                 920                 925


Thr Leu Leu Ala Leu Gly Cys His Ile Ala His Val Asn Pro Ala Ala 
    930                 935                 940


Glu Glu Asp Leu Lys Lys Val Lys Leu Pro Lys Asn Tyr Met Met Ser 
945                 950                 955                 960


Asn Gly Tyr Lys Pro Ala Pro Leu Asp Leu Ser Asp Val Lys Leu Leu 
                965                 970                 975


Pro Pro Gln Glu Ile Leu Val Asp Lys Leu Ala Glu Asn Ala His Asn 
            980                 985                 990


Val Trp Ala Lys Asp Arg Ile Lys Gln Gly Trp Thr Tyr Gly Ile Gln 
        995                 1000                1005


Gln Asp Leu Lys Asn Lys Arg Asn Pro Arg Leu Val Pro Tyr Ala Leu 
    1010                1015                1020


Leu Asp Glu Arg Thr Lys Lys Ser Asn Arg Asp Ser Leu Arg Glu Ala 
1025                1030                1035                1040


Val Arg Thr Phe Val Gly Tyr Gly Tyr Asn Ile Glu Pro Ser Asp Gln 
                1045                1050                1055


Glu Leu Ala Asp Ser Ala Val Glu Lys Val Ser Ile Asp Lys Ile Arg 
            1060                1065                1070


Phe Phe Arg Val Glu Arg Ser Tyr Ala Val Arg Ser Gly Lys Trp Tyr 
        1075                1080                1085


Phe Glu Phe Glu Val Val Thr Gly Gly Asp Met Arg Val Gly Trp Ala 
    1090                1095                1100


Arg Pro Gly Cys Arg Pro Asp Val Glu Leu Gly Ala Asp Asp Gln Ala 
1105                1110                1115                1120


Phe Val Phe Glu Gly Asn Arg Gly Gln Arg Trp His Gln Gly Ser Gly 
                1125                1130                1135


Tyr Phe Gly Arg Thr Trp Gln Pro Gly Asp Val Val Gly Cys Met Ile 
            1140                1145                1150


Asn Leu Asp Asp Ala Ser Met Ile Phe Thr Leu Asn Gly Glu Leu Leu 
        1155                1160                1165


Ile Thr Asn Lys Gly Ser Glu Leu Ala Phe Ala Asp Tyr Glu Ile Glu 
    1170                1175                1180


Asn Gly Phe Val Pro Ile Cys Cys Leu Gly Leu Ser Gln Ile Gly Arg 
1185                1190                1195                1200


Met Asn Leu Gly Thr Asp Ala Ser Thr Phe Lys Phe Tyr Thr Met Cys 
                1205                1210                1215


Gly Leu Gln Glu Gly Phe Glu Pro Phe Ala Val Asn Met Asn Arg Asp 
            1220                1225                1230


Val Ala Met Trp Phe Ser Lys Arg Leu Pro Thr Phe Val Asn Val Pro 
        1235                1240                1245


Lys Asp His Pro His Ile Glu Val Met Arg Ile Asp Gly Thr Met Asp 
    1250                1255                1260


Ser Pro Pro Cys Leu Lys Val Thr His Lys Thr Phe Gly Thr Gln Asn 
1265                1270                1275                1280


Ser Asn Ala Asp Met Ile Tyr Cys Arg Leu Ser Met Pro Val Glu Cys 
                1285                1290                1295


His Ser Ser Phe Ser His Ser Pro Cys Leu Asp Ser Glu Ala Phe Gln 
            1300                1305                1310


Lys Arg Lys Gln Met Gln Glu Ile Leu Ser His Thr Thr Thr Gln Cys 
        1315                1320                1325


Tyr Tyr Ala Ile Arg Ile Phe Ala Gly Gln Asp Pro Ser Cys Val Trp 
    1330                1335                1340


Val Gly Trp Val Thr Pro Asp Tyr His Leu Tyr Ser Glu Lys Phe Asp 
1345                1350                1355                1360


Leu Asn Lys Asn Cys Thr Val Thr Val Thr Leu Gly Asp Glu Arg Gly 
                1365                1370                1375


Arg Val His Glu Ser Val Lys Arg Ser Asn Cys Tyr Met Val Trp Gly 
            1380                1385                1390


Gly Asp Ile Val Ala Ser Ser Gln Arg Ser Asn Arg Ser Asn Val Asp 
        1395                1400                1405


Leu Glu Ile Gly Cys Leu Val Asp Leu Ala Met Gly Met Leu Ser Phe 
    1410                1415                1420


Ser Ala Asn Gly Lys Glu Leu Gly Thr Cys Tyr Gln Val Glu Pro Asn 
1425                1430                1435                1440


Thr Lys Val Phe Pro Ala Val Phe Leu Gln Pro Thr Ser Thr Ser Leu 
                1445                1450                1455


Phe Gln Phe Glu Leu Gly Lys Leu Lys Asn Ala Met Pro Leu Ser Ala 
            1460                1465                1470


Ala Ile Phe Arg Ser Glu Glu Lys Asn Pro Val Pro Gln Cys Pro Pro 
        1475                1480                1485


Arg Leu Asp Val Gln Thr Ile Gln Pro Val Leu Trp Ser Arg Met Pro 
    1490                1495                1500


Asn Ser Phe Leu Lys Val Glu Thr Glu Arg Val Ser Glu Arg His Gly 
1505                1510                1515                1520


Trp Val Val Gln Cys Leu Glu Pro Leu Gln Met Met Ala Leu His Ile 
                1525                1530                1535


Pro Glu Glu Asn Arg Cys Val Asp Ile Leu Glu Leu Cys Glu Gln Glu 
            1540                1545                1550


Asp Leu Met Arg Phe His Tyr His Thr Leu Arg Leu Tyr Ser Ala Val 
        1555                1560                1565


Cys Ala Leu Gly Asn Ser Arg Val Ala Tyr Ala Leu Cys Ser His Val 
    1570                1575                1580


Asp Leu Ser Gln Leu Phe Tyr Ala Ile Asp Asn Lys Tyr Leu Pro Gly 
1585                1590                1595                1600


Leu Leu Arg Ser Gly Phe Tyr Asp Leu Leu Ile Ser Ile His Leu Ala 
                1605                1610                1615


Ser Ala Lys Glu Arg Lys Leu Met Met Lys Asn Glu Tyr Ile Ile Pro 
            1620                1625                1630


Ile Thr Ser Thr Thr Arg Asn Ile Arg Leu Phe Pro Asp Glu Ser Lys 
        1635                1640                1645


Arg His Gly Leu Pro Gly Val Gly Leu Arg Thr Cys Leu Lys Pro Gly 
    1650                1655                1660


Phe Arg Phe Ser Thr Pro Cys Phe Val Val Thr Gly Glu Asp His Gln 
1665                1670                1675                1680


Lys Gln Ser Pro Glu Ile Pro Leu Glu Ser Leu Arg Thr Lys Ala Leu 
                1685                1690                1695


Ser Met Leu Thr Glu Ala Val Gln Cys Ser Gly Ala His Ile Arg Asp 
            1700                1705                1710


Pro Val Gly Gly Ser Val Glu Phe Gln Phe Val Pro Val Leu Lys Leu 
        1715                1720                1725


Ile Gly Thr Leu Leu Val Met Gly Val Phe Asp Asp Asp Asp Val Arg 
    1730                1735                1740


Gln Ile Leu Leu Leu Ile Asp Pro Ser Val Phe Gly Glu His Ser Ala 
1745                1750                1755                1760


Gly Thr Glu Glu Gly Ala Glu Lys Glu Glu Val Thr Gln Val Glu Glu 
                1765                1770                1775


Lys Ala Val Glu Ala Gly Glu Lys Ala Gly Lys Glu Ala Pro Val Lys 
            1780                1785                1790


Gly Leu Leu Gln Thr Arg Leu Pro Glu Ser Val Lys Leu Gln Met Cys 
        1795                1800                1805


Glu Leu Leu Ser Tyr Leu Cys Asp Cys Glu Leu Gln His Arg Val Glu 
    1810                1815                1820


Ala Ile Val Ala Phe Gly Asp Ile Tyr Val Ser Lys Leu Gln Ala Asn 
1825                1830                1835                1840


Gln Lys Phe Arg Tyr Asn Glu Leu Met Gln Ala Leu Asn Met Ser Ala 
                1845                1850                1855


Ala Leu Thr Ala Arg Lys Thr Lys Glu Phe Arg Ser Pro Pro Gln Glu 
            1860                1865                1870


Gln Ile Asn Met Leu Leu Asn Phe Gln Leu Gly Glu Asn Cys Pro Cys 
        1875                1880                1885


Pro Glu Glu Ile Arg Glu Glu Leu Tyr Asp Phe His Glu Asp Leu Leu 
    1890                1895                1900


Leu His Cys Gly Val Pro Leu Glu Glu Glu Glu Glu Glu Glu Glu Asp 
1905                1910                1915                1920


Thr Ser Trp Thr Gly Lys Leu Cys Ala Leu Val Tyr Lys Ile Lys Gly 
                1925                1930                1935


Pro Pro Lys Pro Glu Lys Glu Gln Pro Thr Glu Glu Glu Glu Arg Cys 
            1940                1945                1950


Pro Thr Thr Leu Lys Glu Leu Ile Ser Gln Thr Met Ile Cys Trp Ala 
        1955                1960                1965


Gln Glu Asp Gln Ile Gln Asp Ser Glu Leu Val Arg Met Met Phe Asn 
    1970                1975                1980


Leu Leu Arg Arg Gln Tyr Asp Ser Ile Gly Glu Leu Leu Gln Ala Leu 
1985                1990                1995                2000


Arg Lys Thr Tyr Thr Ile Ser His Thr Ser Val Ser Asp Thr Ile Asn 
                2005                2010                2015


Leu Leu Ala Ala Leu Gly Gln Ile Arg Ser Leu Leu Ser Val Arg Met 
            2020                2025                2030


Gly Lys Glu Glu Glu Leu Leu Met Ile Asn Gly Leu Gly Asp Ile Met 
        2035                2040                2045


Asn Asn Lys Val Phe Tyr Gln His Pro Asn Leu Met Arg Val Leu Gly 
    2050                2055                2060


Met His Glu Thr Val Met Glu Val Met Val Asn Val Leu Gly Thr Glu 
2065                2070                2075                2080


Lys Ser Gln Ile Ala Phe Pro Lys Met Val Ala Ser Cys Cys Arg Phe 
                2085                2090                2095


Leu Cys Tyr Phe Cys Arg Ile Ser Arg Gln Asn Gln Lys Ala Met Phe 
            2100                2105                2110


Glu His Leu Ser Tyr Leu Leu Glu Asn Ser Ser Val Gly Leu Ala Ser 
        2115                2120                2125


Pro Ser Met Arg Gly Ser Thr Pro Leu Asp Val Ala Ala Ser Ser Val 
    2130                2135                2140


Met Asp Asn Asn Glu Leu Ala Leu Ser Leu Glu Glu Pro Asp Leu Glu 
2145                2150                2155                2160


Lys Val Val Thr Tyr Leu Ala Gly Cys Gly Leu Gln Ser Cys Pro Met 
                2165                2170                2175


Leu Leu Ala Lys Gly Tyr Pro Asp Val Gly Trp Asn Pro Ile Glu Gly 
            2180                2185                2190


Glu Arg Tyr Leu Ser Phe Leu Arg Phe Ala Val Phe Val Asn Ser Glu 
        2195                2200                2205


Ser Val Glu Glu Asn Ala Ser Val Val Val Lys Leu Leu Ile Arg Arg 
    2210                2215                2220


Pro Glu Cys Phe Gly Pro Ala Leu Arg Gly Glu Gly Gly Asn Gly Leu 
2225                2230                2235                2240


Leu Ala Ala Met Gln Gly Ala Ile Lys Ile Ser Glu Asn Pro Ala Leu 
                2245                2250                2255


Asp Leu Pro Ser Gln Gly Tyr Lys Arg Glu Val Ser Thr Gly Asp Asp 
            2260                2265                2270


Glu Glu Glu Glu Glu Ile Val His Met Gly Asn Ala Ile Met Ser Phe 
        2275                2280                2285


Tyr Ser Ala Leu Ile Asp Leu Leu Gly Arg Cys Ala Pro Glu Met His 
    2290                2295                2300


Leu Ile Gln Thr Gly Lys Gly Glu Ala Ile Arg Ile Arg Ser Ile Leu 
2305                2310                2315                2320


Arg Ser Leu Val Pro Thr Glu Asp Leu Val Gly Ile Ile Ser Ile Pro 
                2325                2330                2335


Leu Lys Leu Pro Ser Leu Asn Lys Asp Gly Ser Val Ser Glu Pro Asp 
            2340                2345                2350


Met Ala Ala Asn Phe Cys Pro Asp His Lys Ala Pro Met Val Leu Phe 
        2355                2360                2365


Leu Asp Arg Val Tyr Gly Ile Lys Asp Gln Thr Phe Leu Leu His Leu 
    2370                2375                2380


Leu Glu Val Gly Phe Leu Pro Asp Leu Arg Ala Ser Ala Ser Leu Asp 
2385                2390                2395                2400


Thr Val Ser Leu Ser Thr Thr Glu Ala Ala Leu Ala Leu Asn Arg Tyr 
                2405                2410                2415


Ile Cys Ser Ala Val Leu Pro Leu Leu Thr Arg Cys Ala Pro Leu Phe 
            2420                2425                2430


Ala Gly Thr Glu His Cys Thr Ser Leu Ile Asp Ser Thr Leu Gln Thr 
        2435                2440                2445


Ile Tyr Arg Leu Ser Lys Gly Arg Ser Leu Thr Lys Ala Gln Arg Asp 
    2450                2455                2460


Thr Ile Glu Glu Cys Leu Leu Ala Ile Cys Asn His Leu Arg Pro Ser 
2465                2470                2475                2480


Met Leu Gln Gln Leu Leu Arg Arg Leu Val Phe Asp Val Pro Gln Leu 
                2485                2490                2495


Asn Glu Tyr Cys Lys Met Pro Leu Lys Leu Leu Thr Asn His Tyr Glu 
            2500                2505                2510


Gln Cys Trp Lys Tyr Tyr Cys Leu Pro Ser Gly Trp Gly Ser Tyr Gly 
        2515                2520                2525


Leu Ala Val Glu Glu Glu Leu His Leu Thr Glu Lys Leu Phe Trp Gly 
    2530                2535                2540


Ile Phe Asp Ser Leu Ser His Lys Lys Tyr Asp Pro Asp Leu Phe Arg 
2545                2550                2555                2560


Met Ala Leu Pro Cys Leu Ser Ala Ile Ala Gly Ala Leu Pro Pro Asp 
                2565                2570                2575


Tyr Leu Asp Thr Arg Ile Thr Ala Thr Leu Glu Lys Gln Ile Ser Val 
            2580                2585                2590


Asp Ala Asp Gly Asn Phe Asp Pro Lys Pro Ile Asn Thr Met Asn Phe 
        2595                2600                2605


Ser Leu Pro Glu Lys Leu Glu Tyr Ile Val Thr Lys Tyr Ala Glu His 
    2610                2615                2620


Ser His Asp Lys Trp Ala Cys Asp Lys Ser Gln Ser Gly Trp Lys Tyr 
2625                2630                2635                2640


Gly Ile Ser Leu Asp Glu Asn Val Lys Thr His Pro Leu Ile Arg Pro 
                2645                2650                2655


Phe Lys Thr Leu Thr Glu Lys Glu Lys Glu Ile Tyr Arg Trp Pro Ala 
            2660                2665                2670


Arg Glu Ser Leu Lys Thr Met Leu Ala Val Gly Trp Thr Val Glu Arg 
        2675                2680                2685


Thr Lys Glu Gly Glu Ala Leu Val Gln Gln Arg Glu Asn Glu Lys Leu 
    2690                2695                2700


Arg Ser Val Ser Gln Ala Asn Gln Gly Asn Ser Tyr Ser Pro Ala Pro 
2705                2710                2715                2720


Leu Asp Leu Ser Asn Val Val Leu Ser Arg Glu Leu Gln Gly Met Val 
                2725                2730                2735


Glu Val Val Ala Glu Asn Tyr His Asn Ile Trp Ala Lys Lys Lys Lys 
            2740                2745                2750


Leu Glu Leu Glu Ser Lys Gly Gly Gly Ser His Pro Leu Leu Val Pro 
        2755                2760                2765


Tyr Asp Thr Leu Thr Ala Lys Glu Lys Phe Lys Asp Arg Glu Lys Ala 
    2770                2775                2780


Gln Asp Leu Phe Lys Phe Leu Gln Val Asn Gly Ile Ile Val Ser Arg 
2785                2790                2795                2800


Gly Met Lys Asp Met Glu Leu Asp Ala Ser Ser Met Glu Lys Arg Phe 
                2805                2810                2815


Ala Tyr Lys Phe Leu Lys Lys Ile Leu Lys Tyr Val Asp Ser Ala Gln 
            2820                2825                2830


Glu Phe Ile Ala His Leu Glu Ala Ile Val Ser Ser Gly Lys Thr Glu 
        2835                2840                2845


Lys Ser Pro Arg Asp Gln Glu Ile Lys Phe Phe Ala Lys Val Leu Leu 
    2850                2855                2860


Pro Leu Val Asp Gln Tyr Phe Thr Ser His Cys Leu Tyr Phe Leu Ser 
2865                2870                2875                2880


Ser Pro Leu Lys Pro Leu Ser Ser Ser Gly Tyr Ala Ser His Lys Glu 
                2885                2890                2895


Lys Glu Met Val Ala Gly Leu Phe Cys Lys Leu Ala Ala Leu Val Arg 
            2900                2905                2910


His Arg Ile Ser Leu Phe Gly Ser Asp Ser Thr Thr Met Val Ser Cys 
        2915                2920                2925


Leu His Ile Leu Ala Gln Thr Leu Asp Thr Arg Thr Val Met Lys Ser 
    2930                2935                2940


Gly Ser Glu Leu Val Lys Ala Gly Leu Arg Ala Phe Phe Glu Asn Ala 
2945                2950                2955                2960


Ala Glu Asp Leu Glu Lys Thr Ser Glu Asn Leu Lys Leu Gly Lys Phe 
                2965                2970                2975


Thr His Ser Arg Thr Gln Ile Lys Gly Val Ser Gln Asn Ile Asn Tyr 
            2980                2985                2990


Thr Thr Val Ala Leu Leu Pro Ile Leu Thr Ser Ile Phe Glu His Val 
        2995                3000                3005


Thr Gln His Gln Phe Gly Met Asp Leu Leu Leu Gly Asp Val Gln Ile 
    3010                3015                3020


Ser Cys Tyr His Ile Leu Cys Ser Leu Tyr Ser Leu Gly Thr Gly Lys 
3025                3030                3035                3040


Asn Ile Tyr Val Glu Arg Gln Arg Pro Ala Leu Gly Glu Cys Leu Ala 
                3045                3050                3055


Ser Leu Ala Ala Ala Ile Pro Val Ala Phe Leu Glu Pro Thr Leu Asn 
            3060                3065                3070


Arg Tyr Asn Pro Leu Ser Val Phe Asn Thr Lys Thr Pro Arg Glu Arg 
        3075                3080                3085


Ser Ile Leu Gly Met Pro Asp Thr Val Glu Asp Met Cys Pro Asp Ile 
    3090                3095                3100


Pro Gln Leu Glu Gly Leu Met Lys Glu Ile Asn Asp Leu Ala Glu Ser 
3105                3110                3115                3120


Gly Ala Arg Tyr Thr Glu Met Pro His Val Ile Glu Val Ile Leu Pro 
                3125                3130                3135


Met Leu Cys Asn Tyr Leu Ser Tyr Trp Trp Glu Arg Gly Pro Glu Asn 
            3140                3145                3150


Leu Pro Pro Ser Thr Gly Pro Cys Cys Thr Lys Val Thr Ser Glu His 
        3155                3160                3165


Leu Ser Leu Ile Leu Gly Asn Ile Leu Lys Ile Ile Asn Asn Asn Leu 
    3170                3175                3180


Gly Ile Asp Glu Ala Ser Trp Met Lys Arg Ile Ala Val Tyr Ala Gln 
3185                3190                3195                3200


Pro Ile Ile Ser Lys Ala Arg Pro Asp Leu Leu Arg Ser His Phe Ile 
                3205                3210                3215


Pro Thr Leu Glu Lys Leu Lys Lys Lys Ala Val Lys Thr Val Gln Glu 
            3220                3225                3230


Glu Glu Gln Leu Lys Ala Asp Gly Lys Gly Asp Thr Gln Glu Ala Glu 
        3235                3240                3245


Leu Leu Ile Leu Asp Glu Phe Ala Val Leu Cys Arg Asp Leu Tyr Ala 
    3250                3255                3260


Phe Tyr Pro Met Leu Ile Arg Tyr Val Asp Asn Asn Arg Ser Asn Trp 
3265                3270                3275                3280


Leu Lys Ser Pro Asp Ala Asp Ser Asp Gln Leu Phe Arg Met Val Ala 
                3285                3290                3295


Glu Val Phe Ile Leu Trp Cys Lys Ser His Asn Phe Lys Arg Glu Glu 
            3300                3305                3310


Gln Asn Phe Val Ile Gln Asn Glu Ile Asn Asn Leu Ala Phe Leu Thr 
        3315                3320                3325


Gly Asp Ser Lys Ser Lys Met Ser Lys Ala Met Gln Val Lys Ser Gly 
    3330                3335                3340


Gly Gln Asp Gln Glu Arg Lys Lys Thr Lys Arg Arg Gly Asp Leu Tyr 
3345                3350                3355                3360


Ser Ile Gln Thr Ser Leu Ile Val Ala Ala Leu Lys Lys Met Leu Pro 
                3365                3370                3375


Ile Gly Leu Asn Met Cys Thr Pro Gly Asp Gln Glu Leu Ile Ser Leu 
            3380                3385                3390


Ala Lys Ser Arg Tyr Ser His Arg Asp Thr Asp Glu Glu Val Arg Glu 
        3395                3400                3405


His Leu Arg Asn Asn Leu His Leu Gln Glu Lys Ser Asp Asp Pro Ala 
    3410                3415                3420


Val Lys Trp Gln Leu Asn Leu Tyr Lys Asp Val Leu Lys Ser Glu Glu 
3425                3430                3435                3440


Pro Phe Asn Pro Glu Lys Thr Val Glu Arg Val Gln Arg Ile Ser Ala 
                3445                3450                3455


Ala Val Phe His Leu Glu Gln Val Glu Gln Pro Leu Arg Ser Lys Lys 
            3460                3465                3470


Ala Val Trp His Lys Leu Leu Ser Lys Gln Arg Lys Arg Ala Val Val 
        3475                3480                3485


Ala Cys Phe Arg Met Ala Pro Leu Tyr Asn Leu Pro Arg His Arg Ser 
    3490                3495                3500


Ile Asn Leu Phe Leu His Gly Tyr Gln Arg Phe Trp Ile Glu Thr Glu 
3505                3510                3515                3520


Glu Tyr Ser Phe Glu Glu Lys Leu Val Gln Asp Leu Ala Lys Ser Pro 
                3525                3530                3535


Lys Val Glu Glu Glu Glu Glu Glu Glu Thr Glu Lys Gln Pro Asp Pro 
            3540                3545                3550


Leu His Gln Ile Ile Leu Tyr Phe Ser Arg Asn Ala Leu Thr Glu Arg 
        3555                3560                3565


Ser Lys Leu Glu Asp Asp Pro Leu Tyr Thr Ser Tyr Ser Ser Met Met 
    3570                3575                3580


Ala Lys Ser Cys Gln Ser Gly Glu Asp Glu Glu Glu Asp Glu Asp Lys 
3585                3590                3595                3600


Glu Lys Thr Phe Glu Glu Lys Glu Met Glu Lys Gln Lys Thr Leu Tyr 
                3605                3610                3615


Gln Gln Ala Arg Leu His Glu Arg Gly Ala Ala Glu Met Val Leu Gln 
            3620                3625                3630


Met Ile Ser Ala Ser Lys Gly Glu Met Ser Pro Met Val Val Glu Thr 
        3635                3640                3645


Leu Lys Leu Gly Ile Ala Ile Leu Asn Gly Gly Asn Ala Gly Val Gln 
    3650                3655                3660


Gln Lys Met Leu Asp Tyr Leu Lys Glu Lys Lys Asp Ala Gly Phe Phe 
3665                3670                3675                3680


Gln Ser Leu Ser Gly Leu Met Gln Ser Cys Ser Val Leu Asp Leu Asn 
                3685                3690                3695


Ala Phe Glu Arg Gln Asn Lys Ala Glu Gly Leu Gly Met Val Thr Glu 
            3700                3705                3710


Glu Gly Thr Leu Ile Val Arg Glu Arg Gly Glu Lys Val Leu Gln Asn 
        3715                3720                3725


Asp Glu Phe Thr Arg Asp Leu Phe Arg Phe Leu Gln Leu Leu Cys Glu 
    3730                3735                3740


Gly His Asn Ser Asp Phe Gln Asn Phe Leu Arg Thr Gln Met Gly Asn 
3745                3750                3755                3760


Thr Thr Thr Val Asn Val Ile Ile Ser Thr Val Asp Tyr Leu Leu Arg 
                3765                3770                3775


Leu Gln Glu Ser Ile Ser Asp Phe Tyr Trp Tyr Tyr Ser Gly Lys Asp 
            3780                3785                3790


Ile Ile Asp Glu Ser Gly Gln His Asn Phe Ser Lys Ala Leu Ala Val 
        3795                3800                3805


Thr Lys Gln Ile Phe Asn Ser Leu Thr Glu Tyr Ile Gln Gly Pro Cys 
    3810                3815                3820


Ile Gly Asn Gln Gln Ser Leu Ala His Ser Arg Leu Trp Asp Ala Val 
3825                3830                3835                3840


Val Gly Phe Leu His Val Phe Ala Asn Met Gln Met Lys Leu Ser Gln 
                3845                3850                3855


Asp Ser Ser Gln Ile Glu Leu Leu Lys Glu Leu Leu Asp Leu Leu Gln 
            3860                3865                3870


Asp Met Val Val Met Leu Leu Ser Leu Leu Glu Gly Asn Val Val Asn 
        3875                3880                3885


Gly Thr Ile Gly Lys Gln Met Val Asp Thr Leu Val Glu Ser Ser Thr 
    3890                3895                3900


Asn Val Glu Met Ile Leu Lys Phe Phe Asp Met Phe Leu Lys Leu Lys 
3905                3910                3915                3920


Asp Leu Thr Ser Ser Asp Thr Phe Lys Glu Tyr Asp Pro Asp Gly Lys 
                3925                3930                3935


Gly Ile Ile Ser Lys Lys Glu Phe Gln Lys Ala Met Glu Gly Gln Lys 
            3940                3945                3950


Gln Tyr Thr Gln Ser Glu Ile Asp Phe Leu Leu Ser Cys Ala Glu Ala 
        3955                3960                3965


Asp Glu Asn Asp Met Phe Asn Tyr Val Asp Phe Val Asp Arg Phe His 
    3970                3975                3980


Glu Pro Ala Lys Asp Ile Gly Phe Asn Val Ala Val Leu Leu Thr Asn 
3985                3990                3995                4000


Leu Ser Glu His Met Pro Asn Asp Ser Arg Leu Lys Cys Leu Leu Asp 
                4005                4010                4015


Pro Ala Glu Ser Val Leu Asn Tyr Phe Glu Pro Tyr Leu Gly Arg Ile 
            4020                4025                4030


Glu Ile Met Gly Gly Ala Lys Lys Ile Glu Arg Val Tyr Phe Glu Ile 
        4035                4040                4045


Ser Glu Ser Ser Arg Thr Gln Trp Glu Lys Pro Gln Val Lys Glu Ser 
    4050                4055                4060


Lys Arg Gln Phe Ile Phe Asp Val Val Asn Glu Gly Gly Glu Gln Glu 
4065                4070                4075                4080


Lys Met Glu Leu Phe Val Asn Phe Cys Glu Asp Thr Ile Phe Glu Met 
                4085                4090                4095


Gln Leu Ala Ser Gln Ile Ser Glu Ser Asp Ser Ala Asp Arg Pro Glu 
            4100                4105                4110


Glu Glu Glu Glu Asp Glu Asp Ser Ser Tyr Val Leu Glu Ile Ala Gly 
        4115                4120                4125


Glu Glu Glu Glu Asp Gly Ser Leu Glu Pro Ala Ser Ala Phe Ala Met 
    4130                4135                4140


Ala Cys Ala Ser Val Lys Arg Asn Val Thr Asp Phe Leu Lys Arg Ala 
4145                4150                4155                4160


Thr Leu Lys Asn Leu Arg Lys Gln Tyr Arg Asn Val Lys Lys Met Thr 
                4165                4170                4175


Ala Lys Glu Leu Val Lys Val Leu Phe Ser Phe Phe Trp Met Leu Phe 
            4180                4185                4190


Val Gly Leu Phe Gln Leu Leu Phe Thr Ile Leu Gly Gly Ile Phe Gln 
        4195                4200                4205


Ile Leu Trp Ser Thr Val Phe Gly Gly Gly Leu Val Glu Gly Ala Lys 
    4210                4215                4220


Asn Ile Arg Val Thr Lys Ile Leu Gly Asp Met Pro Asp Pro Thr Gln 
4225                4230                4235                4240


Phe Gly Ile His Asp Asp Thr Met Glu Ala Glu Arg Ala Glu Val Met 
                4245                4250                4255


Glu Pro Gly Ile Thr Thr Glu Leu Val His Phe Ile Lys Gly Glu Lys 
            4260                4265                4270


Gly Asp Thr Asp Ile Met Ser Asp Leu Phe Gly Leu His Pro Lys Lys 
        4275                4280                4285


Glu Gly Ser Leu Lys His Gly Pro Glu Val Gly Leu Gly Asp Leu Ser 
    4290                4295                4300


Glu Ile Ile Gly Lys Asp Glu Pro Pro Thr Leu Glu Ser Thr Val Gln 
4305                4310                4315                4320


Lys Lys Arg Lys Ala Gln Ala Ala Glu Met Lys Ala Ala Asn Glu Ala 
                4325                4330                4335


Glu Gly Lys Val Glu Ser Glu Lys Ala Asp Met Glu Asp Gly Glu Lys 
            4340                4345                4350


Glu Asp Lys Asp Lys Glu Glu Glu Gln Ala Glu Tyr Leu Trp Thr Glu 
        4355                4360                4365


Val Thr Lys Lys Lys Lys Arg Arg Cys Gly Gln Lys Val Glu Lys Pro 
    4370                4375                4380


Glu Ala Phe Thr Ala Asn Phe Phe Lys Gly Leu Glu Ile Tyr Gln Thr 
4385                4390                4395                4400


Lys Leu Leu His Tyr Leu Ala Arg Asn Phe Tyr Asn Leu Arg Phe Leu 
                4405                4410                4415


Ala Leu Phe Val Ala Phe Ala Ile Asn Phe Ile Leu Leu Phe Tyr Lys 
            4420                4425                4430


Val Thr Glu Glu Pro Leu Glu Glu Glu Thr Glu Asp Val Ala Asn Leu 
        4435                4440                4445


Trp Asn Ser Phe Asn Asp Glu Glu Glu Glu Glu Ala Met Val Phe Phe 
    4450                4455                4460


Val Leu Gln Glu Ser Thr Gly Tyr Met Ala Pro Thr Leu Arg Ala Leu 
4465                4470                4475                4480


Ala Ile Ile His Thr Ile Ile Ser Leu Val Cys Val Val Gly Tyr Tyr 
                4485                4490                4495


Cys Leu Lys Val Pro Leu Val Val Phe Lys Arg Glu Lys Glu Ile Ala 
            4500                4505                4510


Arg Lys Leu Glu Phe Asp Gly Leu Tyr Ile Thr Glu Gln Pro Ser Glu 
        4515                4520                4525


Asp Asp Ile Lys Gly Gln Trp Asp Arg Leu Val Ile Asn Thr Pro Ser 
    4530                4535                4540


Phe Pro Asn Asn Tyr Trp Asp Lys Phe Val Lys Arg Lys Val Ile Asn 
4545                4550                4555                4560


Lys Tyr Gly Asp Leu Tyr Gly Ala Glu Arg Ile Ala Glu Leu Leu Gly 
                4565                4570                4575


Leu Asp Lys Asn Ala Leu Asp Phe Ser Pro Val Glu Glu Thr Lys Ala 
            4580                4585                4590


Glu Ala Ala Ser Leu Val Ser Trp Leu Ser Ser Ile Asp Met Lys Tyr 
        4595                4600                4605


His Ile Trp Lys Leu Gly Val Val Phe Thr Asp Asn Ser Phe Leu Tyr 
    4610                4615                4620


Leu Ala Trp Tyr Thr Thr Met Ser Val Leu Gly His Tyr Asn Asn Phe 
4625                4630                4635                4640


Phe Phe Ala Ala His Leu Leu Asp Ile Ala Met Gly Phe Lys Thr Leu 
                4645                4650                4655


Arg Thr Ile Leu Ser Ser Val Thr His Asn Gly Lys Gln Leu Val Leu 
            4660                4665                4670


Thr Val Gly Leu Leu Ala Val Val Val Tyr Leu Tyr Thr Val Val Ala 
        4675                4680                4685


Phe Asn Phe Phe Arg Lys Phe Tyr Asn Lys Ser Glu Asp Asp Asp Glu 
    4690                4695                4700


Pro Asp Met Lys Cys Asp Asp Met Met Thr Cys Tyr Leu Phe His Met 
4705                4710                4715                4720


Tyr Val Gly Val Arg Ala Gly Gly Gly Ile Gly Asp Glu Ile Glu Asp 
                4725                4730                4735


Pro Ala Gly Asp Pro Tyr Glu Met Tyr Arg Ile Val Phe Asp Ile Thr 
            4740                4745                4750


Phe Phe Phe Phe Val Ile Val Ile Leu Leu Ala Ile Ile Gln Gly Leu 
        4755                4760                4765


Ile Ile Asp Ala Phe Gly Glu Leu Arg Asp Gln Gln Glu Gln Val Arg 
    4770                4775                4780


Glu Asp Met Glu Thr Lys Cys Phe Ile Cys Gly Ile Gly Asn Asp Tyr 
4785                4790                4795                4800


Phe Asp Thr Thr Pro His Gly Phe Glu Thr His Thr Leu Gln Glu His 
                4805                4810                4815


Asn Leu Ala Asn Tyr Leu Phe Phe Leu Met Tyr Leu Ile Asn Lys Asp 
            4820                4825                4830


Glu Thr Glu His Thr Gly Gln Glu Ser Tyr Val Trp Lys Met Tyr Gln 
        4835                4840                4845


Glu Arg Cys Trp Asp Phe Phe Pro Ala Gly Asp Cys Phe Arg Lys Gln 
    4850                4855                4860


Tyr Glu Asp Gln Leu Gly 
4865                4870


<210>  1025
<211>  5532
<212>  DNA
<213>  Homo sapiens

<400>  1025
ggcccaccgc cgcccaggca aggccgccct gccttgggcg cagcgctgcc atggctgggg     60

gccgtggggc ccccgggcgc ggccgggacg agcctccgga gagctacccg caacgacagg    120

accacgagct acaggccctg gaggccatct acggcgcgga cttccaagac ctgcggccgg    180

acgcttgcgg accggtcaaa gagccccctg aaatcaattt agttttgtac cctcaaggcc    240

taactggtga agaagtatat gtaaaagtgg atttgagggt taaatgccca cctacctatc    300

cagatgtagt tcctgaaata gagttaaaaa atgccaaagg tctatcaaat gaaagtgtca    360

atttgttaaa atctcgccta gaagaactgg ccaagaaaca ctgtggggag gtgatgatct    420

ttgaactggc ttaccacgtg cagtcatttc tcagcgagca taacaagccc cctcccaagt    480

cttttcatga agaaatgctg gaaaggcggg ctcaggagga gcagcagagg ctgttggagg    540

ccaagcggaa agaagagcag gagcaacgtg aaatcctgca tgagattcag agaaggaaag    600

aagagataaa agaagagaaa aaaaggaaag aaatggctaa gcaggaacgt ttggaaattg    660

ctagtttgtc aaaccaagat catacctcta agaaggaccc aggaggacac agaacggctg    720

ccattctaca tggaggctct cctgactttg taggaaatgg taaacatcgg gcaaactcct    780

caggaaggtc taggcgagaa cgtcagtatt ctgtatgtaa tagtgaagat tctcctggct    840

cttgtgaaat tctgtatttc aatatgggga gtcctgatca gctcatggtg cacaaaggga    900

aatgtattgg cagtgatgaa caacttggaa aattagtcta caatgctttg gaaacagcca    960

ctggtggctt tgtcttgttg tatgagtggg tccttcagtg gcagaaaaaa atgggtccat   1020

tccttaccag tcaagaaaaa gagaagattg ataagtgcaa aaagcagatt caaggaacag   1080

aaacagaatt caactcactg gtaaaattga gccatccaaa tgtagtacgc taccttgcaa   1140

tgaatctcaa agagcaagac gactccatcg tggtggacat tttagtggag cacattagtg   1200

gggtctctct tgctgcacac ctgagccact caggccccat ccctgtgcat cagcttcgca   1260

ggtacacagc tcagctcctg tcaggccttg attatctgca cagcaattct gtggtgcata   1320

aggtcctgag tgcatctaat gtcttggtgg atgcagaagg caccgtcaag attacggact   1380

atagcatttc taagcgcctc gcagacattt gcaaggagga tgtgtttgag caaacccgag   1440

ttcgttttag tgacaatgct ctgccttata aaacggggaa gaaaggagat gtttggcgtc   1500

ttggccttct gctgctgtcc ctcagccaag gacaggaatg tggagagtac cctgtgacca   1560

tccctagtga cttaccagct gactttcaag attttctaaa gaaatgtgtg tgcttggatg   1620

acaaggaaag atggagtccc cagcagttgt tgaaacacag ctttataaat ccccagccaa   1680

aaatgcctct agtggaacaa agtcctgaag attctgaagg acaagattat gttgagactg   1740

ttattcctag caaccggcta cccagtgctg ccttctttag tgagacacag agacagtttt   1800

cccgatactt cattgagttt gaagaattac aacttcttgg taaaggagct tttggagctg   1860

tcatcaaggt gcagaacaag ttggacggct gctgctacgc agtgaagcgc atccccatca   1920

acccggccag ccggcagttc cgcaggatca agggcgaagt gacactgctg tcacggctgc   1980

accatgagaa cattgtgcgc tactacaacg cctggatcga gcggcacgag cggccggcgg   2040

gaccggggac gccgcccccg gactccgggc ccctggccaa ggatgaccga gctgcacgcg   2100

ggcagccggc gagcgacaca gacggcctgg acagcgtaga ggccgccgcg ccgccaccca   2160

tcctcagcag ctcggtggag tggagcactt cgggcgagcg ctcggccagt gcccgtttcc   2220

ccgccaccgg cccgggctcc agcgatgacg aggacgacga cgaggacgag cacggtggcg   2280

tcttctccca gtccttcctg cctgcttcag attctgaaag tgatattatc tttgacaatg   2340

aagatgagaa cagtaaaagt cagaatcagg atgaagattg caatgaaaag aatggctgcc   2400

atgaaagtga gccatcagtg acgactgagg ctgtgcacta cctatacatc cagatggagt   2460

actgtgagaa gagcacttta cgagacacca ttgaccaggg actgtatcga gacaccgtca   2520

gactctggag gctttttcga gagattctgg atggattagc ttatatccat gagaaaggaa   2580

tgattcaccg ggatttgaag cctgtcaaca tttttttgga ttctgatgac catgtgaaaa   2640

taggtgattt tggtttggcg acagaccatc tagccttttc tgctgacagc aaacaagacg   2700

atcagacagg agacttgatt aagtcagacc cttcaggtca cttaactggg atggttggca   2760

ctgctctcta tgtaagccca gaggtccaag gaagcaccaa atctgcatac aaccagaaag   2820

tggatctctt cagcctggga attatcttct ttgagatgtc ctatcacccc atggtcacgg   2880

cttcagaaag gatctttgtt ctcaaccaac tcagagatcc cacttcgcct aagtttccag   2940

aagactttga cgatggagag catgcaaagc agaaatcagt catctcctgg ctgttgaacc   3000

acgatccagc aaaacggccc acagccacag aactgctcaa gagtgagctg ctgcccccac   3060

cccagatgga ggagtcagag ctgcatgaag tgctgcacca cacgctgacc aacgtggatg   3120

ggaaggccta ccgcaccatg atggcccaga tcttctcgca gcgcatctcc cctgccatcg   3180

attacaccta tgacagcgac atactgaagg gcaacttctc aatccgtaca gccaagatgc   3240

agcagcatgt gtgtgaaacc atcatccgca tctttaaaag acatggagct gttcagttgt   3300

gtactccact actgcttccc cgaaacagac aaatatatga gcacaacgaa gctgccctat   3360

tcatggacca cagcgggatg ctggtgatgc ttccttttga cctgcggatc ccttttgcaa   3420

gatatgtggc aagaaataat atattgaatt taaaacgata ctgcatagaa cgtgtgttca   3480

ggccgcgcaa gttagatcga tttcatccca aagaacttct ggagtgtgca tttgatattg   3540

tcacttctac caccaacagc tttctgccca ctgctgaaat tatctacact atctatgaaa   3600

tcatccaaga gtttccagca cttcaggaaa gaaattacag tatttatttg aaccatacca   3660

tgttattgaa agcaatactc ttacactgtg ggatcccaga agataaactc agtcaagtct   3720

acattattct gtatgatgct gtgacagaga agctgacgag gagagaagtg gaagctaaat   3780

tttgtaatct gtctttgtct tctaatagtc tgtgtcgact ctacaagttt attgaacaga   3840

agggagattt gcaagatctt atgccaacaa taaattcatt aataaaacag aaaacaggta   3900

ttgcacagtt ggtgaagtat ggcttaaaag acctagagga ggttgttgga ctgttgaaga   3960

aactcggcat caagttacag gtcttgatca atttgggctt ggtttacaag gtgcagcagc   4020

acaatggaat catcttccag tttgtggctt tcatcaaacg aaggcaaagg gctgtacctg   4080

aaatcctcgc agctggaggc agatatgacc tgctgattcc ccagtttaga gggccacaag   4140

ctctggggcc agttcccact gccattgggg tcagcatagc tatagacaag atatctgctg   4200

ctgtcctcaa catggaggaa tctgttacaa taagctcttg tgacctcctg gttgtaagtg   4260

ttggccagat gtctatgtcc agggccatca acctaaccca gaaactctgg acagcaggca   4320

tcacagcaga aatcatgtac gactggtcac agtcccaaga ggaattacaa gagtactgca   4380

gacatcatga aatcacctat gtggcccttg tctcggataa agaaggaagc catgtcaagg   4440

ttaagtcttt cgagaaggaa aggcagacag agaagcgtgt gctggagact gaacttgtgg   4500

accatgtact gcagaaactg aggactaaag tcactgatga aaggaatggc agagaagctt   4560

ccgataatct tgcagtgcaa aatctgaagg ggtcattttc taatgcttca ggtttgtttg   4620

aaatccatgg agcaacagtg gttcccattg tgagtgtgct agccccggag aagctgtcag   4680

ccagcactag gaggcgctat gaaactcagg tacaaactcg acttcagacc tcccttgcca   4740

acttacatca gaaaagcagt gaaattgaaa ttctggctgt ggatctaccc aaagaaacaa   4800

tattacagtt tttatcatta gagtgggatg ctgatgaaca ggcatttaac acaactgtga   4860

agcagctgct gtcacgcctg ccaaagcaaa gatacctcaa attagtctgt gatgaaattt   4920

ataacatcaa agtagaaaaa aaggtgtctg tgctatttct gtacagctat agagatgact   4980

actacagaat cttattttaa ccctaaagaa ctgtcgttaa cctcattcaa acagacagag   5040

gcttatactg gaataatgga atgttgtaca ttcatcataa tttaaaatta aattctaaga   5100

agaggctggg tgcagtggct cacaccttta atcccagcac tttgggaagc caaggcagga   5160

agactgcttg aaaccaggag tttgagacca gcctgagcaa caaagcaaga ccccatctct   5220

ataaaaacta aaaaaattag ttgggcatgg tggcacatgc ctgtagtccc agctactcca   5280

gaggctgaga tggatcatct gagcctcagg aggttgaggc tgcagtgagc tgtgactgcg   5340

ccactgcact ccagtctggg acaacagagc aagaccctgt cttaaaaaaa aaaagaaaaa   5400

aaaaattttt ttctaagaag ctgtcctaca aagttgagct ttgttagttt ttcatgtgta   5460

atatattata aatttatctt ttgggatata ataaatgctt tcatatacct gcaaaaaaaa   5520

aaaaaaaaaa aa                                                       5532


<210>  1026
<211>  1649
<212>  PRT
<213>  Homo sapiens

<400>  1026

Met Ala Gly Gly Arg Gly Ala Pro Gly Arg Gly Arg Asp Glu Pro Pro 
1               5                   10                  15


Glu Ser Tyr Pro Gln Arg Gln Asp His Glu Leu Gln Ala Leu Glu Ala 
            20                  25                  30


Ile Tyr Gly Ala Asp Phe Gln Asp Leu Arg Pro Asp Ala Cys Gly Pro 
        35                  40                  45


Val Lys Glu Pro Pro Glu Ile Asn Leu Val Leu Tyr Pro Gln Gly Leu 
    50                  55                  60


Thr Gly Glu Glu Val Tyr Val Lys Val Asp Leu Arg Val Lys Cys Pro 
65                  70                  75                  80


Pro Thr Tyr Pro Asp Val Val Pro Glu Ile Glu Leu Lys Asn Ala Lys 
                85                  90                  95


Gly Leu Ser Asn Glu Ser Val Asn Leu Leu Lys Ser Arg Leu Glu Glu 
            100                 105                 110


Leu Ala Lys Lys His Cys Gly Glu Val Met Ile Phe Glu Leu Ala Tyr 
        115                 120                 125


His Val Gln Ser Phe Leu Ser Glu His Asn Lys Pro Pro Pro Lys Ser 
    130                 135                 140


Phe His Glu Glu Met Leu Glu Arg Arg Ala Gln Glu Glu Gln Gln Arg 
145                 150                 155                 160


Leu Leu Glu Ala Lys Arg Lys Glu Glu Gln Glu Gln Arg Glu Ile Leu 
                165                 170                 175


His Glu Ile Gln Arg Arg Lys Glu Glu Ile Lys Glu Glu Lys Lys Arg 
            180                 185                 190


Lys Glu Met Ala Lys Gln Glu Arg Leu Glu Ile Ala Ser Leu Ser Asn 
        195                 200                 205


Gln Asp His Thr Ser Lys Lys Asp Pro Gly Gly His Arg Thr Ala Ala 
    210                 215                 220


Ile Leu His Gly Gly Ser Pro Asp Phe Val Gly Asn Gly Lys His Arg 
225                 230                 235                 240


Ala Asn Ser Ser Gly Arg Ser Arg Arg Glu Arg Gln Tyr Ser Val Cys 
                245                 250                 255


Asn Ser Glu Asp Ser Pro Gly Ser Cys Glu Ile Leu Tyr Phe Asn Met 
            260                 265                 270


Gly Ser Pro Asp Gln Leu Met Val His Lys Gly Lys Cys Ile Gly Ser 
        275                 280                 285


Asp Glu Gln Leu Gly Lys Leu Val Tyr Asn Ala Leu Glu Thr Ala Thr 
    290                 295                 300


Gly Gly Phe Val Leu Leu Tyr Glu Trp Val Leu Gln Trp Gln Lys Lys 
305                 310                 315                 320


Met Gly Pro Phe Leu Thr Ser Gln Glu Lys Glu Lys Ile Asp Lys Cys 
                325                 330                 335


Lys Lys Gln Ile Gln Gly Thr Glu Thr Glu Phe Asn Ser Leu Val Lys 
            340                 345                 350


Leu Ser His Pro Asn Val Val Arg Tyr Leu Ala Met Asn Leu Lys Glu 
        355                 360                 365


Gln Asp Asp Ser Ile Val Val Asp Ile Leu Val Glu His Ile Ser Gly 
    370                 375                 380


Val Ser Leu Ala Ala His Leu Ser His Ser Gly Pro Ile Pro Val His 
385                 390                 395                 400


Gln Leu Arg Arg Tyr Thr Ala Gln Leu Leu Ser Gly Leu Asp Tyr Leu 
                405                 410                 415


His Ser Asn Ser Val Val His Lys Val Leu Ser Ala Ser Asn Val Leu 
            420                 425                 430


Val Asp Ala Glu Gly Thr Val Lys Ile Thr Asp Tyr Ser Ile Ser Lys 
        435                 440                 445


Arg Leu Ala Asp Ile Cys Lys Glu Asp Val Phe Glu Gln Thr Arg Val 
    450                 455                 460


Arg Phe Ser Asp Asn Ala Leu Pro Tyr Lys Thr Gly Lys Lys Gly Asp 
465                 470                 475                 480


Val Trp Arg Leu Gly Leu Leu Leu Leu Ser Leu Ser Gln Gly Gln Glu 
                485                 490                 495


Cys Gly Glu Tyr Pro Val Thr Ile Pro Ser Asp Leu Pro Ala Asp Phe 
            500                 505                 510


Gln Asp Phe Leu Lys Lys Cys Val Cys Leu Asp Asp Lys Glu Arg Trp 
        515                 520                 525


Ser Pro Gln Gln Leu Leu Lys His Ser Phe Ile Asn Pro Gln Pro Lys 
    530                 535                 540


Met Pro Leu Val Glu Gln Ser Pro Glu Asp Ser Glu Gly Gln Asp Tyr 
545                 550                 555                 560


Val Glu Thr Val Ile Pro Ser Asn Arg Leu Pro Ser Ala Ala Phe Phe 
                565                 570                 575


Ser Glu Thr Gln Arg Gln Phe Ser Arg Tyr Phe Ile Glu Phe Glu Glu 
            580                 585                 590


Leu Gln Leu Leu Gly Lys Gly Ala Phe Gly Ala Val Ile Lys Val Gln 
        595                 600                 605


Asn Lys Leu Asp Gly Cys Cys Tyr Ala Val Lys Arg Ile Pro Ile Asn 
    610                 615                 620


Pro Ala Ser Arg Gln Phe Arg Arg Ile Lys Gly Glu Val Thr Leu Leu 
625                 630                 635                 640


Ser Arg Leu His His Glu Asn Ile Val Arg Tyr Tyr Asn Ala Trp Ile 
                645                 650                 655


Glu Arg His Glu Arg Pro Ala Gly Pro Gly Thr Pro Pro Pro Asp Ser 
            660                 665                 670


Gly Pro Leu Ala Lys Asp Asp Arg Ala Ala Arg Gly Gln Pro Ala Ser 
        675                 680                 685


Asp Thr Asp Gly Leu Asp Ser Val Glu Ala Ala Ala Pro Pro Pro Ile 
    690                 695                 700


Leu Ser Ser Ser Val Glu Trp Ser Thr Ser Gly Glu Arg Ser Ala Ser 
705                 710                 715                 720


Ala Arg Phe Pro Ala Thr Gly Pro Gly Ser Ser Asp Asp Glu Asp Asp 
                725                 730                 735


Asp Glu Asp Glu His Gly Gly Val Phe Ser Gln Ser Phe Leu Pro Ala 
            740                 745                 750


Ser Asp Ser Glu Ser Asp Ile Ile Phe Asp Asn Glu Asp Glu Asn Ser 
        755                 760                 765


Lys Ser Gln Asn Gln Asp Glu Asp Cys Asn Glu Lys Asn Gly Cys His 
    770                 775                 780


Glu Ser Glu Pro Ser Val Thr Thr Glu Ala Val His Tyr Leu Tyr Ile 
785                 790                 795                 800


Gln Met Glu Tyr Cys Glu Lys Ser Thr Leu Arg Asp Thr Ile Asp Gln 
                805                 810                 815


Gly Leu Tyr Arg Asp Thr Val Arg Leu Trp Arg Leu Phe Arg Glu Ile 
            820                 825                 830


Leu Asp Gly Leu Ala Tyr Ile His Glu Lys Gly Met Ile His Arg Asp 
        835                 840                 845


Leu Lys Pro Val Asn Ile Phe Leu Asp Ser Asp Asp His Val Lys Ile 
    850                 855                 860


Gly Asp Phe Gly Leu Ala Thr Asp His Leu Ala Phe Ser Ala Asp Ser 
865                 870                 875                 880


Lys Gln Asp Asp Gln Thr Gly Asp Leu Ile Lys Ser Asp Pro Ser Gly 
                885                 890                 895


His Leu Thr Gly Met Val Gly Thr Ala Leu Tyr Val Ser Pro Glu Val 
            900                 905                 910


Gln Gly Ser Thr Lys Ser Ala Tyr Asn Gln Lys Val Asp Leu Phe Ser 
        915                 920                 925


Leu Gly Ile Ile Phe Phe Glu Met Ser Tyr His Pro Met Val Thr Ala 
    930                 935                 940


Ser Glu Arg Ile Phe Val Leu Asn Gln Leu Arg Asp Pro Thr Ser Pro 
945                 950                 955                 960


Lys Phe Pro Glu Asp Phe Asp Asp Gly Glu His Ala Lys Gln Lys Ser 
                965                 970                 975


Val Ile Ser Trp Leu Leu Asn His Asp Pro Ala Lys Arg Pro Thr Ala 
            980                 985                 990


Thr Glu Leu Leu Lys Ser Glu Leu Leu Pro Pro Pro Gln Met Glu Glu 
        995                 1000                1005


Ser Glu Leu His Glu Val Leu His His Thr Leu Thr Asn Val Asp Gly 
    1010                1015                1020


Lys Ala Tyr Arg Thr Met Met Ala Gln Ile Phe Ser Gln Arg Ile Ser 
1025                1030                1035                1040


Pro Ala Ile Asp Tyr Thr Tyr Asp Ser Asp Ile Leu Lys Gly Asn Phe 
                1045                1050                1055


Ser Ile Arg Thr Ala Lys Met Gln Gln His Val Cys Glu Thr Ile Ile 
            1060                1065                1070


Arg Ile Phe Lys Arg His Gly Ala Val Gln Leu Cys Thr Pro Leu Leu 
        1075                1080                1085


Leu Pro Arg Asn Arg Gln Ile Tyr Glu His Asn Glu Ala Ala Leu Phe 
    1090                1095                1100


Met Asp His Ser Gly Met Leu Val Met Leu Pro Phe Asp Leu Arg Ile 
1105                1110                1115                1120


Pro Phe Ala Arg Tyr Val Ala Arg Asn Asn Ile Leu Asn Leu Lys Arg 
                1125                1130                1135


Tyr Cys Ile Glu Arg Val Phe Arg Pro Arg Lys Leu Asp Arg Phe His 
            1140                1145                1150


Pro Lys Glu Leu Leu Glu Cys Ala Phe Asp Ile Val Thr Ser Thr Thr 
        1155                1160                1165


Asn Ser Phe Leu Pro Thr Ala Glu Ile Ile Tyr Thr Ile Tyr Glu Ile 
    1170                1175                1180


Ile Gln Glu Phe Pro Ala Leu Gln Glu Arg Asn Tyr Ser Ile Tyr Leu 
1185                1190                1195                1200


Asn His Thr Met Leu Leu Lys Ala Ile Leu Leu His Cys Gly Ile Pro 
                1205                1210                1215


Glu Asp Lys Leu Ser Gln Val Tyr Ile Ile Leu Tyr Asp Ala Val Thr 
            1220                1225                1230


Glu Lys Leu Thr Arg Arg Glu Val Glu Ala Lys Phe Cys Asn Leu Ser 
        1235                1240                1245


Leu Ser Ser Asn Ser Leu Cys Arg Leu Tyr Lys Phe Ile Glu Gln Lys 
    1250                1255                1260


Gly Asp Leu Gln Asp Leu Met Pro Thr Ile Asn Ser Leu Ile Lys Gln 
1265                1270                1275                1280


Lys Thr Gly Ile Ala Gln Leu Val Lys Tyr Gly Leu Lys Asp Leu Glu 
                1285                1290                1295


Glu Val Val Gly Leu Leu Lys Lys Leu Gly Ile Lys Leu Gln Val Leu 
            1300                1305                1310


Ile Asn Leu Gly Leu Val Tyr Lys Val Gln Gln His Asn Gly Ile Ile 
        1315                1320                1325


Phe Gln Phe Val Ala Phe Ile Lys Arg Arg Gln Arg Ala Val Pro Glu 
    1330                1335                1340


Ile Leu Ala Ala Gly Gly Arg Tyr Asp Leu Leu Ile Pro Gln Phe Arg 
1345                1350                1355                1360


Gly Pro Gln Ala Leu Gly Pro Val Pro Thr Ala Ile Gly Val Ser Ile 
                1365                1370                1375


Ala Ile Asp Lys Ile Ser Ala Ala Val Leu Asn Met Glu Glu Ser Val 
            1380                1385                1390


Thr Ile Ser Ser Cys Asp Leu Leu Val Val Ser Val Gly Gln Met Ser 
        1395                1400                1405


Met Ser Arg Ala Ile Asn Leu Thr Gln Lys Leu Trp Thr Ala Gly Ile 
    1410                1415                1420


Thr Ala Glu Ile Met Tyr Asp Trp Ser Gln Ser Gln Glu Glu Leu Gln 
1425                1430                1435                1440


Glu Tyr Cys Arg His His Glu Ile Thr Tyr Val Ala Leu Val Ser Asp 
                1445                1450                1455


Lys Glu Gly Ser His Val Lys Val Lys Ser Phe Glu Lys Glu Arg Gln 
            1460                1465                1470


Thr Glu Lys Arg Val Leu Glu Thr Glu Leu Val Asp His Val Leu Gln 
        1475                1480                1485


Lys Leu Arg Thr Lys Val Thr Asp Glu Arg Asn Gly Arg Glu Ala Ser 
    1490                1495                1500


Asp Asn Leu Ala Val Gln Asn Leu Lys Gly Ser Phe Ser Asn Ala Ser 
1505                1510                1515                1520


Gly Leu Phe Glu Ile His Gly Ala Thr Val Val Pro Ile Val Ser Val 
                1525                1530                1535


Leu Ala Pro Glu Lys Leu Ser Ala Ser Thr Arg Arg Arg Tyr Glu Thr 
            1540                1545                1550


Gln Val Gln Thr Arg Leu Gln Thr Ser Leu Ala Asn Leu His Gln Lys 
        1555                1560                1565


Ser Ser Glu Ile Glu Ile Leu Ala Val Asp Leu Pro Lys Glu Thr Ile 
    1570                1575                1580


Leu Gln Phe Leu Ser Leu Glu Trp Asp Ala Asp Glu Gln Ala Phe Asn 
1585                1590                1595                1600


Thr Thr Val Lys Gln Leu Leu Ser Arg Leu Pro Lys Gln Arg Tyr Leu 
                1605                1610                1615


Lys Leu Val Cys Asp Glu Ile Tyr Asn Ile Lys Val Glu Lys Lys Val 
            1620                1625                1630


Ser Val Leu Phe Leu Tyr Ser Tyr Arg Asp Asp Tyr Tyr Arg Ile Leu 
        1635                1640                1645


Phe 



<210>  1027
<211>  1126
<212>  DNA
<213>  Homo sapiens

<400>  1027
ccagcctagg ccgaacttcc ggctctcact gctaggggct taagcggagg gagtcgagcc     60

agcgtcgccg cgatggtgtt gttggagagc gagcagttcc tgacggagct gaccagactt    120

ttccagaagt gccggacgtc gggcagcgtc tatatcacct tgaagaagta tgacggtcga    180

accaaaccca ttccaaagaa gggtactgtg gagggctttg agcccgcaga caacaagtgt    240

ctgttaagag ctaccgatgg gaagaagaag atcagcactg tggtgagctc caaggaagtg    300

aataagtttc agatggctta ttcaaacctc cttagagcta acatggatgg gctgaagaag    360

agagacaaaa agaacaaaac taagaagacc aaagcagcag cagcagcagc agcagcagca    420

cctgccgcag cagcaacagc accaacaaca gcagcaacaa cagcagcaac agcagcacag    480

taaagggcat acatttcctg ctttcaccaa ttaaccactg aattgctatt ttttcctttt    540

ggccagatag ctaggtttct ggttccccca cagtaggtgt tttcacataa gattagggtc    600

cttttggaaa gaatagttgc agtgtttata ggatagttgt ggtaagaatc tagtttattt    660

tgcatttggc taattggtct gtgctgcatg gttatatact cctggattat agattaaaag    720

tctctgtaga catctctgtg aagagcaagc tatcattaaa catgtctgtt tatcagcact    780

gtctctttat tcctttccca acccatttta atagttctgg caataactac taaatctaga    840

atgatgtgat taatgaatag gctttagctc tataatatct tctaggttat tagaattgaa    900

acctgacagt tttataaaaa gtcatgttat ctcatgagct gcttcccacc tggctgtata    960

attttatcat catggttccc cagtttcgat gagttctcac agtcaaatga gagtttgttt   1020

aaccacctta ggagaaacat actacaaagt catcaagaat aaaggttcca aagtaattat   1080

gatttttggt ttctttatgc cctttggttt ggatattttc atgtgc                  1126


<210>  1028
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  1028

Met Val Leu Leu Glu Ser Glu Gln Phe Leu Thr Glu Leu Thr Arg Leu 
1               5                   10                  15


Phe Gln Lys Cys Arg Thr Ser Gly Ser Val Tyr Ile Thr Leu Lys Lys 
            20                  25                  30


Tyr Asp Gly Arg Thr Lys Pro Ile Pro Lys Lys Gly Thr Val Glu Gly 
        35                  40                  45


Phe Glu Pro Ala Asp Asn Lys Cys Leu Leu Arg Ala Thr Asp Gly Lys 
    50                  55                  60


Lys Lys Ile Ser Thr Val Val Ser Ser Lys Glu Val Asn Lys Phe Gln 
65                  70                  75                  80


Met Ala Tyr Ser Asn Leu Leu Arg Ala Asn Met Asp Gly Leu Lys Lys 
                85                  90                  95


Arg Asp Lys Lys Asn Lys Thr Lys Lys Thr Lys Ala Ala Ala Ala Ala 
            100                 105                 110


Ala Ala Ala Ala Pro Ala Ala Ala Ala Thr Ala Pro Thr Thr Ala Ala 
        115                 120                 125


Thr Thr Ala Ala Thr Ala Ala Gln 
    130                 135


<210>  1029
<211>  3584
<212>  DNA
<213>  Homo sapiens

<400>  1029
gctggtccta tcccactggg accgtcgctg ccactcagcc agagagccag catcttggca     60

agggctgggc ctggagtgaa gctggaaggg ctagcatgga gagcctgtca cctgggggac    120

cacctggcca cccttaccag ggggaggcct ctacctgctg gcagctcaca gtgagggtcc    180

tggaggcgcg gaacctgcgc tgggctgacc tgttgagtga ggccgaccct tacgtgatcc    240

tacagctgtc gaccgcacct ggaatgaagt ttaagaccaa gacgctcacc gacaccagtc    300

atcctgtgtg gaatgaggcc ttccgtttcc ttatccaaag tcaggtcaag aatgttctgg    360

agcttagcat ctatgatgag gactcagtca cggaggatga catctgcttc aaggttctct    420

atgacatctc agaagtcctc cctggcaagc tgctccggaa aaccttctcc cagagtcccc    480

agggagagga ggagctggat gtggagttcc tgatggaaga aacgtcagat cgcccagaaa    540

acctcatcac caacaaagtc attgtggccc gagagctgtc atgcctggat gtgcatctgg    600

acagcacagg gagcaccgct gtggttgcag atcaggacaa gctggagctg gagctggtgc    660

tgaaggggtc ctatgaggac acacagacat ccttcctggg cacagcctct gccttccgct    720

tccactacat ggcagcccta gagacagagc tgagcgggcg cctgaggagc tccagaagca    780

atggctggaa tggggacaac tcagctgggt acctcactgt gcccctgagg cccttgacca    840

ttgggaagga ggtgactatg gatgttcctg ctccaaatgc cccaggagtg aggctgcagc    900

tcaaggcaga gggctgccct gaggagctgg ccgtgcacct gggcttcaat ctctgtgcag    960

aggagcaggc cttcctgagc aggaggaagc aggtggtggc caaggccctg aagcaggccc   1020

tgcagctgga cagagacctg caggaggatg aggtacccgt tgtgggcatc atggccacag   1080

gaggaggtgc ccgggccatg acctcactct acggccacct attggccttg cagaagctgg   1140

gcctcctaga ctgtgtgacc tacttcagtg gcatctctgg ctctacgtgg acaatggccc   1200

acctgtacgg ggaccctgag tggtcgcaga gggacctgga gggacctatc agatacgccc   1260

gggagcacct ggccaagagc aagctggagg tcttttcccc agagcgcctg gcgagctacc   1320

gccgggagct ggagctgcgg gctgagcagg gccaccccac gacctttgtg gacctgtggg   1380

cgctagtgct ggagtccatg ctgcacggcc aggtgatgga tcagaagctg tcaggacaga   1440

gagccgccct ggaacggggt cagaaccctc tgcccctcta cttgagcctc aatgtcaaag   1500

agaacaatct ggagacactg gacttcaagg agtgggttga gttctccccc tatgaggtcg   1560

gtttcctgaa gtacggggcc ttcgtccctc ctgagctctt cggctccgag ttcttcatgg   1620

gacggctgat gaggaggatc ccggagcccc ggatctgctt tctggaagcc atctggagca   1680

acattttctc cctgaacctg ctggatgcct ggtatgacct caccagttct ggggagtcct   1740

ggaaacagca catcaaggac aagaccagga gcttagagaa ggagcccctg accacctcgg   1800

ggacctcctc gcggctggag gcctcgtggc tgcagccagg cacggcgctg gcccaggcat   1860

ttaaaggctt cctgacaggc aggcccctcc accagcgcag ccccaacttc ctccagggcc   1920

tccagctgca ccaggactac tgtagccaca aagacttctc cacctgggca gactaccagc   1980

ttgactccat gcccagccag ctgaccccca aggagccccg gctctgcctg gtggacgccg   2040

cctacttcat caacaccagc tctccctcca tgttccggcc aggccgcagg ctggacctca   2100

tcctctcctt cgactactcc ctatctgcgc ccttcgaggc actgcagcag acggagctgt   2160

actgccgggc ccgggggctg cccttccccc gggtggaacc cagccctcag gaccagcacc   2220

agccaaggga atgccacctc ttctcagacc ccgcctgccc cgaggccccg atcctgctgc   2280

acttcccgct ggtcaatgcc tccttcaagg accactcagc ccccggtgtc cagcgcagcc   2340

ccgcagagct ccagggtggc caagtggatc tcaccggggc cacctgcccc tacaccctgt   2400

ccaacatgac ctacaaggag gaagacttcg agcgcctgct gcggctcagt gactacaacg   2460

tgcagaccag ccagggtgcc atcctgcagg ccctgaggac cgcgctgaag caccggactc   2520

tagaggcgag gcctccaagg gcacagacct gaggttgctc agaggctgca ggaccctcca   2580

gggcctgcgg gcataacctg atctgtagct gggctcagcc acaggccttc ctggttggag   2640

ttctgggctc tcccaggcct gggtggcctc tgtagctggt ctcactgccc agagggaact   2700

gcacacacag acttctctct tacgttcatg gctggcttga gatgagttga aaataacttc   2760

gccaggccag tgtgtagaac agctggtcca accagacaga ctttcacacc acaattactt   2820

ccatgcctga gcaggataga tttgaagtgc aagccggagg cagcagatca ggagtaggga   2880

caggaaggac aggggatgcc tgacctgaca ggtggcttca ggcctcggga atcacaagac   2940

atcctgaaca cattgcctcc tcatcttctt cctgctcctc cacctcctcc tctccttgtc   3000

cttctcctct ttgtcctcct gctttccgta tccaagtctt gtacttgttt aaatttattc   3060

ctaaatattt tattcttttt gataagtgga gttactttct taatttcatt tagattattc   3120

attgctattt tatagaaata caatggattt ttaaatgttg atcttgtatt ccgcaatctt   3180

gctgaagttg tttaccggct ctaatacttt tgcggatttc ttagaatttt ctgtagacag   3240

atcatgccat ctccaaatag agatggtttt acttcttcct gtctgatctg aatgcctttt   3300

atttattttt cccaattgcc ctgagcagta caatgatgaa cacacgtttc aagagcagac   3360

atcttgtctt gttcctgact ctgacaagaa agcataagtc tctcaccatt tagtgtgatt   3420

ttagctgtgg gtttttcttg gacatcctta tcaggttgag aaagttctct tttatttcta   3480

gtttattgag tgttttatga tgaaacggtg ttaggttttg tcaagtgatt tttctgtgtc   3540

tatgggcatg atcatgtggt tttgtcgtgt attttattaa tgta                    3584


<210>  1030
<211>  818
<212>  PRT
<213>  Homo sapiens

<400>  1030

Met Glu Ser Leu Ser Pro Gly Gly Pro Pro Gly His Pro Tyr Gln Gly 
1               5                   10                  15


Glu Ala Ser Thr Cys Trp Gln Leu Thr Val Arg Val Leu Glu Ala Arg 
            20                  25                  30


Asn Leu Arg Trp Ala Asp Leu Leu Ser Glu Ala Asp Pro Tyr Val Ile 
        35                  40                  45


Leu Gln Leu Ser Thr Ala Pro Gly Met Lys Phe Lys Thr Lys Thr Leu 
    50                  55                  60


Thr Asp Thr Ser His Pro Val Trp Asn Glu Ala Phe Arg Phe Leu Ile 
65                  70                  75                  80


Gln Ser Gln Val Lys Asn Val Leu Glu Leu Ser Ile Tyr Asp Glu Asp 
                85                  90                  95


Ser Val Thr Glu Asp Asp Ile Cys Phe Lys Val Leu Tyr Asp Ile Ser 
            100                 105                 110


Glu Val Leu Pro Gly Lys Leu Leu Arg Lys Thr Phe Ser Gln Ser Pro 
        115                 120                 125


Gln Gly Glu Glu Glu Leu Asp Val Glu Phe Leu Met Glu Glu Thr Ser 
    130                 135                 140


Asp Arg Pro Glu Asn Leu Ile Thr Asn Lys Val Ile Val Ala Arg Glu 
145                 150                 155                 160


Leu Ser Cys Leu Asp Val His Leu Asp Ser Thr Gly Ser Thr Ala Val 
                165                 170                 175


Val Ala Asp Gln Asp Lys Leu Glu Leu Glu Leu Val Leu Lys Gly Ser 
            180                 185                 190


Tyr Glu Asp Thr Gln Thr Ser Phe Leu Gly Thr Ala Ser Ala Phe Arg 
        195                 200                 205


Phe His Tyr Met Ala Ala Leu Glu Thr Glu Leu Ser Gly Arg Leu Arg 
    210                 215                 220


Ser Ser Arg Ser Asn Gly Trp Asn Gly Asp Asn Ser Ala Gly Tyr Leu 
225                 230                 235                 240


Thr Val Pro Leu Arg Pro Leu Thr Ile Gly Lys Glu Val Thr Met Asp 
                245                 250                 255


Val Pro Ala Pro Asn Ala Pro Gly Val Arg Leu Gln Leu Lys Ala Glu 
            260                 265                 270


Gly Cys Pro Glu Glu Leu Ala Val His Leu Gly Phe Asn Leu Cys Ala 
        275                 280                 285


Glu Glu Gln Ala Phe Leu Ser Arg Arg Lys Gln Val Val Ala Lys Ala 
    290                 295                 300


Leu Lys Gln Ala Leu Gln Leu Asp Arg Asp Leu Gln Glu Asp Glu Val 
305                 310                 315                 320


Pro Val Val Gly Ile Met Ala Thr Gly Gly Gly Ala Arg Ala Met Thr 
                325                 330                 335


Ser Leu Tyr Gly His Leu Leu Ala Leu Gln Lys Leu Gly Leu Leu Asp 
            340                 345                 350


Cys Val Thr Tyr Phe Ser Gly Ile Ser Gly Ser Thr Trp Thr Met Ala 
        355                 360                 365


His Leu Tyr Gly Asp Pro Glu Trp Ser Gln Arg Asp Leu Glu Gly Pro 
    370                 375                 380


Ile Arg Tyr Ala Arg Glu His Leu Ala Lys Ser Lys Leu Glu Val Phe 
385                 390                 395                 400


Ser Pro Glu Arg Leu Ala Ser Tyr Arg Arg Glu Leu Glu Leu Arg Ala 
                405                 410                 415


Glu Gln Gly His Pro Thr Thr Phe Val Asp Leu Trp Ala Leu Val Leu 
            420                 425                 430


Glu Ser Met Leu His Gly Gln Val Met Asp Gln Lys Leu Ser Gly Gln 
        435                 440                 445


Arg Ala Ala Leu Glu Arg Gly Gln Asn Pro Leu Pro Leu Tyr Leu Ser 
    450                 455                 460


Leu Asn Val Lys Glu Asn Asn Leu Glu Thr Leu Asp Phe Lys Glu Trp 
465                 470                 475                 480


Val Glu Phe Ser Pro Tyr Glu Val Gly Phe Leu Lys Tyr Gly Ala Phe 
                485                 490                 495


Val Pro Pro Glu Leu Phe Gly Ser Glu Phe Phe Met Gly Arg Leu Met 
            500                 505                 510


Arg Arg Ile Pro Glu Pro Arg Ile Cys Phe Leu Glu Ala Ile Trp Ser 
        515                 520                 525


Asn Ile Phe Ser Leu Asn Leu Leu Asp Ala Trp Tyr Asp Leu Thr Ser 
    530                 535                 540


Ser Gly Glu Ser Trp Lys Gln His Ile Lys Asp Lys Thr Arg Ser Leu 
545                 550                 555                 560


Glu Lys Glu Pro Leu Thr Thr Ser Gly Thr Ser Ser Arg Leu Glu Ala 
                565                 570                 575


Ser Trp Leu Gln Pro Gly Thr Ala Leu Ala Gln Ala Phe Lys Gly Phe 
            580                 585                 590


Leu Thr Gly Arg Pro Leu His Gln Arg Ser Pro Asn Phe Leu Gln Gly 
        595                 600                 605


Leu Gln Leu His Gln Asp Tyr Cys Ser His Lys Asp Phe Ser Thr Trp 
    610                 615                 620


Ala Asp Tyr Gln Leu Asp Ser Met Pro Ser Gln Leu Thr Pro Lys Glu 
625                 630                 635                 640


Pro Arg Leu Cys Leu Val Asp Ala Ala Tyr Phe Ile Asn Thr Ser Ser 
                645                 650                 655


Pro Ser Met Phe Arg Pro Gly Arg Arg Leu Asp Leu Ile Leu Ser Phe 
            660                 665                 670


Asp Tyr Ser Leu Ser Ala Pro Phe Glu Ala Leu Gln Gln Thr Glu Leu 
        675                 680                 685


Tyr Cys Arg Ala Arg Gly Leu Pro Phe Pro Arg Val Glu Pro Ser Pro 
    690                 695                 700


Gln Asp Gln His Gln Pro Arg Glu Cys His Leu Phe Ser Asp Pro Ala 
705                 710                 715                 720


Cys Pro Glu Ala Pro Ile Leu Leu His Phe Pro Leu Val Asn Ala Ser 
                725                 730                 735


Phe Lys Asp His Ser Ala Pro Gly Val Gln Arg Ser Pro Ala Glu Leu 
            740                 745                 750


Gln Gly Gly Gln Val Asp Leu Thr Gly Ala Thr Cys Pro Tyr Thr Leu 
        755                 760                 765


Ser Asn Met Thr Tyr Lys Glu Glu Asp Phe Glu Arg Leu Leu Arg Leu 
    770                 775                 780


Ser Asp Tyr Asn Val Gln Thr Ser Gln Gly Ala Ile Leu Gln Ala Leu 
785                 790                 795                 800


Arg Thr Ala Leu Lys His Arg Thr Leu Glu Ala Arg Pro Pro Arg Ala 
                805                 810                 815


Gln Thr 



<210>  1031
<211>  15083
<212>  DNA
<213>  Homo sapiens

<400>  1031
atgagaagaa ggaccacagt gatatttcct ctgcttttgt tgttacaggt tttccaggat     60

ttagggatgg aagtactgtc tggagttgcc aaaggctata acatatgcct ttttgcttat    120

ggacagacag gctctgggaa gacatatacc atgctgggga ccccagcctc tgttgggttg    180

acaccacgga tatgtgaggg tctcttcgtc agggagaaag actgtgcctc actgccttcc    240

tcctgtagga taaaagtaag ttttctagaa atctataatg aacgggtgcg ggatctgttg    300

aagcaatctg gtcaaaaaaa gtcctatacc ctgcgggtca gggagcatcc agagatgggg    360

ccctatgtac aaggtttatc tcaacatgta gttaccaatt ataagcaagt aatccaactc    420

ttggaggagg gaattgcaaa cagaatcaca gcagccaccc atgttcatga ggccagcagc    480

agatcccacg ccattttcac gatccactac acgcaggcaa tcctggagaa caacctccct    540

tctgaaatgg ctagcaagat caaccttgtg gacctagcag gcagcgaaag agcagatccc    600

agttactgta aggaccgcat tgctgaagga gccaatatca acaagtccct tgtgactcta    660

ggaattgtca tctccacctt agcccagaac tcccaagttt tcagcagctg ccagagcctc    720

aacagctcag tcagcaatgg tggtgacagt gggatcctta gctctccttc tgggaccagc    780

agtggagggg caccctcccg aaggcagtct tatatcccat accgagactc tgtgttgacc    840

tggctgctga aggacagcct tggaggcaac tctaaaacca tcatggttgc cataacaagg    900

caaaccatga gcacactgag atatgcatcc agtgccaaaa acattatcaa caagccacga    960

gtaaatgagg tgagaccttt tcagaaaaac ttcagttcat tgagtgatga aaacctgaag   1020

gagctggttc tccaaaatga attgaaggtg gaccagctga ctaaagactg gacccagaag   1080

tggaatgatt ggcaggccct catggagcat tacagtgtgg acatcaacag gaggagggct   1140

ggggtggtca tcgactccag cctgccacac ttgatggcct tggaggatga tgtgctcagc   1200

acaggtgttg tgctctatca tctcaagggt cagtggattg agagagacca ctgcactatc   1260

accagtgcct gtggtgtagt tgttctacga cctgcccgtg gggcccgctg tacagtcaat   1320

ggccgggagg tcactgcctc ctgccgtctg actcaaggag ctgtcataac cctggggaag   1380

gcacagaagt tccgattcaa ccacccagca gaggctgctg tcctgcggca gcgaaggcag   1440

gttggagagg ctgctgctgg tcgtggctcg ttggagtggc tggatttgga tggagatctc   1500

gctgcctccc ggctgggtct ctcccctttg ctttggaagg aaaggagagc gcttgaagag   1560

caatgtgacg aggaccatca gacaccgagg gatggagaga catcccacag ggcccagatt   1620

cagcagcagc agagctacgt agaggatttg aggcatcaaa tcctagcaga agagattcga   1680

gctgcgaagg aactggaatt tgaccaagct tggattagcc agcagattaa agaaaaccag   1740

cagtgtctgc tcagagaaga gacctggctg gccagcttgc aacagcagca gcaagaagac   1800

caggtagcag agaaagaact tgaggcatct gtggcacttg atgcttggct tcagacagat   1860

cctgagattc agccatcccc atttgtccaa agtcagaaaa gggtggtgca cctgcagctc   1920

ctgcggagac acactcttcg ggcagcagag cggaatgtcc ggcggaaaaa ggtctcattc   1980

cagctagaga gaatcatcaa aaagcagagg ctgctggagg cccagaagag actggagaag   2040

ctcacgacat tgtgctggct ccaggatgac agcacccagg agcccccata ccaggtcctc   2100

agccctgatg ccacagtccc acggcctcca tgtagaagca aattgacgag ttgcagttct   2160

ttgagccccc aaagactctg cagcaagcac atgccccagc tacacagcat tttcctaagt   2220

tgggatccct ctaccacatt gccacctagg cctgacccta cacaccaaac atcagagaaa   2280

acatcatcag aagagcattt gccacaggct gcttcctacc ctgcaaggac agggtgcctc   2340

cgcaagaacg gcctgcattc ctcaggtcat gggcagccct gcacagccag agcagccttg   2400

gccaggaagg gagcctcagc tccagacgct tgcctcacca tgagtcccaa ctctgttggc   2460

atccaggaaa tggagatggg ggttaagcag ccccatcaga tggtgagcca gggcttagca   2520

tctctgagga aatcagctaa caaactaaag ccaaggcatg agccaaagat cttcacctct   2580

actacccaga ccagaggggc gaagggacta gcagacccta gccacacaca agctgggtgg   2640

cgaaaagaag ggaaccttgg gacccacaag gctgctaagg gagccagttg caattccttg   2700

tatcctcatg gacccaggca gactgctggg cacggaaagg cagtcaagac tttttggaca   2760

gaatacaaac caccttctcc aagcagggca tcaaaaaggc atcagagggt tctggcaact   2820

agggtcagaa atattaccaa aaagtcctct cacttgcctc ttggcagtcc tttgaagaga   2880

caacaaaata caagggaccc agacaccatg gtcccactca cagatttcag cccagtaatg   2940

gatcattcaa gagaaaaaga caatgattta tctgacacag atagcaacta ctcattggat   3000

tctctctcat gtgtctatgc caaagccctg atagagccac tgaagccaga ggagaggaaa   3060

tgggatttcc cagagccaga gaactctgaa agtgatgaca gccaactatc tgaggactca   3120

ctggctgaga agaggtacca aagccccaaa aacaggctag ggggcaatcg tcccaccaac   3180

aaccgtggcc aacccaggac cagaactaga gcttctgtga ggggcttcac tgcagcctca   3240

gacagtgacc tacttgctca aactcatagg agcttctcct tggatagcct gattgatgca   3300

gaggaagaac tgggggaaga tcagcaagaa gaacctttcc ctggttcagc tgacgagata   3360

cccacagaga ctttttggca cctggaggac tctagtctgc ctgtaatgga ccaagaggca   3420

atatgcaggc ttggtcccat caactacaga acagcagcta ggctggatgc cgtcctgcca   3480

atgagcagtt cgttttacct tgatcctcag ttccaacccc attgcatgca gctttcaaga   3540

gagagcccac tgatgtccat ggattcctgg ttttcctgtg actctaagat caaccccagc   3600

agccccccag gaatagtggg ttctttatgt ccaagtcctg atatgcagga atttcactcc   3660

tgtaaggggg agaggcctgg atactggcca aatactgagg aactaaagcc atcagatgca   3720

gaaacggttc tgccatatag ctccaaactg caccaaggca gtactgagct cctctgcagt   3780

gcaagagatg agcacacagc ctctgctgct gatacgtcta ggctgtctct ctggggaatt   3840

caaaggctta ttcaaccagg agctgatggc acctttcagg gcagatgtat ccctgacatg   3900

acccagcagg gcagctctga agcatcccac aattctagcg tatcaaacgt gctggctgcc   3960

tctgccacca ccttgactca tgtaggcagc acccatgaaa gggattggtc tgcccttcag   4020

cagaagtacc tccttgaact ctcttgtcct gttttggagg ccataggagc acccaagcca   4080

gcttacccct accttgagga agactctggt tccctggccc aagcttctag caaaggagga   4140

gatactctat tgccagttgg ccctagggta tctagcaatc tgaatctcaa caactttcca   4200

gtccatctgt ccagaatcag gcgtttgagg gcagagaaag aacaggacag tttaaatgcc   4260

aaattagaag gtgtttcaga tttctttagc actagtgaga aagaggcgag ttatgacgaa   4320

acttattcgg cagacttaga atcattgtct gcttctcgat ctacaaatgc acaggtcttt   4380

gcaacagaga acgcgatacc agattccatg acagaagcat gtgaagtcaa gcagaacaac   4440

ttggaagaat gccttcagag ttgcaggaaa cctggactga tgacttcctc tgatgaggat   4500

tttttccaga agaacgcttg tcacagtaat gtcactacag ccaccaaagc agaccattgg   4560

tcccaaggct gggctcctct caggaaaaat agtgcagtcc agccagggca attaagtccc   4620

gacagccact acccactaga ggaagagaag acagattgcc aggagagctc taaggaagca   4680

gttagaagac acataaatgt ttcctttgcc cttccttcag gtccagagct ataccttcac   4740

tctgctccct ggaatccatt gtcatcttcc ctgcagcccc cactcttgga aacattctat   4800

gtgaccaaaa gcagggatgc cctgacagaa actgccttag agattccagc ttgcagagaa   4860

gtaagggtac cctccccacc ccccagggaa gcctggggct ttggtcacaa ccaccaagct   4920

ctccaaggtg cttatttgaa gaataatttg ccagtgctgt tacaaaacca gaattctaag   4980

attgcctcat ctcagcaggt cacagctgag ataccagttg atctgaatac cagggaagtc   5040

atcagagaat caggtaaatg ccctggaaat attacagaag aaagccatga ttcagtttat   5100

tcttctgtta ctcagaacag acattttctc ccctctacca gcacaaaagt atgtgaattt   5160

gaaaaccaag ttgtaatttt aaataaaaaa cacagttttc cagcacttga gggaggagag   5220

gtcactgctc agtcctgttg cggtgcttcc tcagacagca ctgagtctgg gaagtctctc   5280

ctctttcgtg aatctgaggc acgagaggaa gaagagctgg atcagaatac ggttctgagg   5340

cagaccatca atgtaagcct tgagaaagac atgccagggg aaagtgctgt ttctttgaaa   5400

tccagatcag tagatcgtag agtaagcagc ccagtgatgg tggcccaggg tggtggccca   5460

acccctaagt gggaagggaa aaatgaaact gggcttcttg aaaaaggtct tcgtcccaaa   5520

gatagctcag aagagtttaa gcttccaggt acaaagcctg catatgaaag gttccagtta   5580

gttgcatgcc ctcaggaaag aaaccccagt gaatgcaagt cacaagaaat gttaaatccc   5640

aacagagaac cttctggaaa gaaacagaat aaaagagtta ataatactga tgaaatggct   5700

aggctaatta ggagtgtaat gcagctggaa aatggcatct tagaaattga atctaagcag   5760

aataagcagg ttcatgcttc ccacacacca ggaaccgata aggagttggt gttccaggac   5820

cagaaggagc aggagaagac tgaccatgcc tttaggccag acagctctgg aaaccctttg   5880

ccctctaagg atcagccatc ttctccaaga cagacagatg atactgtctt tagggatagt   5940

gaagctggag cgatggaggt taacagcatt gggaaccatc cccaggtcca gaaaatcacc   6000

ccaaacccct tcaggtcaag ggaaggtgta cgagagagtg aacctgtgag agagcacacc   6060

cacccagctg gatcggacag acctgccagg gatatttgtg attctttagg gaaacacaca   6120

acttgcagag agttcaccaa cacttctctt cacccacaga gaatgaaagc attggctaga   6180

gctctgccat tgcaacccag gctagagagg tcttctaaga ataatggcca gtttgtaaaa   6240

gcatcagcaa gtctcaaagg gcagccttgg ggcttaggaa gtcttgagga attggagact   6300

gtgaaaggtt ttcaggaaag ccaagtagct gaacacgtaa gtagttccaa ccaagaagag   6360

ccaaaagctc aaggtaaagt tgaagaaatg cctatgcaaa ggggaggcag ccttcaggaa   6420

gaaaataaag tgactcagaa atttcctagt ctcagccagc tttgtaggga cacgtttttc   6480

aggcaggaaa ctgtcagccc attactaagc cggacagaat tctgtacagc tcctcttcac   6540

caagacctga gtaatacctt gcccttgaat tctccaaggt ggccaagaag gtgtcttcat   6600

gtacctgttg ctctaggcat ctcttcactt gactgtgtgc tggatctcac aatgttgaaa   6660

attcataaca gtcccttggt aactggagta gagcatcagg accagagtac ggagaccaga   6720

agccacagcc ccgaaggaaa tgttagaggg cgttcctctg aggcacacac tgcctggtgt   6780

gggtctgtgc gatccatggc catgggatct catagtcaat ctggtgtacc agagagcatt   6840

cctctgggga cagaggacag gatctcagca agcaccagcc cccaagacca tggaaaggac   6900

ctcagaatca ccttgctggg tttcagtacc agtgaagatt ttgcttctga agccgaggtg   6960

gctgtacaaa aagaaataag agtcagttca ctgaacaagg tctctagcca gcctgaaaag   7020

agggtcagct tctccttgga agaggatagt gaccaagcca gcaagccaag gcagaaggca   7080

gagaaggaga ctgaggacgt cggactgacc agcggtgttt ccttagcacc tgtttccctg   7140

ccgagggtgc ccagtccaga gcctaggctg ttggagccct ctgaccatgc atccatgtgc   7200

ctggccatct tggaggagat cagacaggca aaggcccaga gaaagcagct tcatgacttt   7260

gtggccaggg gcacagtcct ttcttactgt gaaactttac tagaacccga atgttcttca   7320

agggttgctg gcaggcctca gtgtaaacaa atagaccagt catcatcaga ccagaccagg   7380

aatgagggtg aagcaccggg atttcatgtg gcatctctat ctgctgaagc agggcagata   7440

gatctgttac ctgatgagag gaaagtccag gccacatctc tgtctgcaga cagctttgaa   7500

tctctgccca atacggaaac tgacagagag ccatgggatc ctgtgcaggc tttctcccat   7560

gctgctcctg ctcaagacag gaaacgtcgt actggagaac tgaggcagtt cgcgggagca   7620

agtgaaccat ttatatgtca ctctagttct tctgaaatca tagagaaaaa gaaagatgca   7680

accagaacac cttcctcagc tgatcctttg gccccagaca gtcctcgttc ttcagcacct   7740

gtggaggagg tcaggagggt agtatcaaag aaggtagtgg ctgccttacc ttctcaggcc   7800

ccttatgatg atcctagagt gactctgcat gagctaagtc agtcagttcc gcaggagact   7860

gcagagggca taccccctgg cagtcaggac agcagcccag agcatcagga acccagaact   7920

ctagacacca catatggaga agtttcagat aatttgttag tgactgcaca gggagaaaaa   7980

acagcccatt ttgaaagtca gtctgtgacc tgtgatgttc agaattctac aagtgcctca   8040

gggcctaagc aagaccatgt ccaatgccct gaggcttcta ctggctttga agaaggtagg   8100

gcaagtccca aacaagatac cattctgcct ggagctctga caagggttgc actggaagct   8160

cccacacagc agtgtgtgca gtgtaaggag agtgttgggt ctgggttgac agaagtctgc   8220

agggctggca gcaaacattc caggccaatt ccactgccag atcaaagacc aagcgcaaat   8280

cctgggggaa ttggggagga agccccatgt agacacccaa gggaagcttt agatggccct   8340

gtcttctcaa ggaaccctga aggcagcagg actctcagcc cgtctagagg gaaagagagc   8400

agaactcttc cttgccgaca gccatgcagt tctcaacctg ttgctactca tgcttattcc   8460

tcccattcct ctactttact gtgttttaga gatggtgacc tagggaagga gcctttcaag   8520

gctgccccac atactatcca cccaccctgt gtagtacctt ccagggccta tgaaatggat   8580

gagacaggag agatctctag gggacctgat gtgcacttga cacatggcct tgagcccaaa   8640

gatgttaaca gggaatttag gctaacagag agcagcactt gtgagccttc tactgtggct   8700

gctgtcctat ctcgagctca aggctgcaga tccccttctg ctcctgacgt gaggacaggt   8760

tccttcagcc actcagctac tgatggaagc gtggggttaa taggggttcc tgagaaaaag   8820

gttgctgaga agcaagcaag cacagaactt gaggctgcct ctttccctgc aggcatgtac   8880

tctgagcccc tgaggcagtt tagggacagc tctgtaggtg accagaatgc acaggtgtgt   8940

caaaccaatc cagaaccacc tgcaacaact cagggaccac acaccctgga tttaagtgaa   9000

gggtctgctg agagcaagtt ggtggtagag ccacagcatg aatgtttaga aaataccact   9060

agatgttttt tggaaaagcc acaattttcc actgagttga gggatcacaa tcgcttggat   9120

tcccaagcca agtttgtagc aaggttaaaa catacctgca gcccccagga agacagtccc   9180

tggcaggaag aagagcagca cagagaccag gcttcaggtg gtggagaagg cttcgcccag   9240

ggtgtgaatc cccttcctga tgaagatggc ttagatggct gtcagatttt agatgctggg   9300

agagaggagg tggctgtggc caagcctcct gtgtccaaga ttttatcaca gggcttcaaa   9360

gacccagcca ctgtgtcctt gaggcaaaat gaaacaccgc agcctgctgc tcagaggagt   9420

ggccacctct acactggcag agagcagcca gcacccaacc acaggggctc acttcctgtg   9480

actacaatct tctctggccc caaacactcc aggtcctccc ccacaccaca gttctcagtt   9540

gtcggctctt ctcgttctct tcaggagctg aacttgagtg tggagcctcc ttcccctaca   9600

gacgaagata cacaggggcc taacagattg tggaacccac atctcagggg ctattcctca   9660

ggaaagtcag tggcaagaac atctctgcag gctgaggaca gcaatcagaa agcctcatct   9720

cgcttggatg atgggactac cgatcacagg cacctgaagc ctgccacccc tccttatcca   9780

atgccttcca ctctctcaca catgccaacc cctgatttca cgaccagctg gatgtctggt   9840

actttggaac aagcccaaca gggaaagcga gagaaactgg gtgtccaggt taggccagaa   9900

aattggtgct ctcagatgga caaaggaatg ctgcactttg gctccagtga catcagtccc   9960

tatgcgctgc cgtggcgtcc ggaggagcct gcacgtatca gctggaagca gtatatgtct  10020

ggcagtgcag tcgatgtttc ctgcagccag aagccccagg ggctgacact atcaaatgtg  10080

gcccggtgct ccagcatgga caatggccta gaagaccaga actccccttt ccactcccac  10140

ctcagcactt acgccaatat ttgtgatctg tcaaccacac acagcagcac tgagaatgcc  10200

cagggttcaa atgaggcctg ggaagtattc cgagggagtt cttcaattgc cttaggagac  10260

ccccacatcc cgacgagccc tgaaggagta gcccccactt cgggtcatga cagaaggcct  10320

cagttcaggg gcccttctgg tgaagcagac tgtctgagga gtaagccccc cttggccaaa  10380

ggaagtgctg caggtccagt ggatgagatt atgctgctgt atccatcaga ggcaggctgc  10440

cctgtgggac agaccaggac gaacacattc gaacagggca cacagaccct cggcagcagg  10500

cgccactgga gcagcactga catctccttt gctcagcctg aagccagtgc agtatcagcc  10560

tttgatctgg cctcatggac cagcatgcac aatctgtctc tccacctctc acagctcctg  10620

cacagtacct cagagctgct tgggagtctc tcccagccag atgtggccag aagggagcag  10680

aacaccaaga gggacatccc agataaagcc ccacaggccc tgatgatgga tggctctact  10740

cagaccactg tggatgaggg cagccagact gacctcacct tacccaccct gtgcctccag  10800

acttcagagg ctgaacctca gggagccaat gtgatccttg aagggctagg ctcagatacc  10860

tcgactgtgt ctcaagaaga gggagatgtg ccaggggtac ctcagaagag agaggcagag  10920

gaaacagcac agaaaatggc tcagctcctc tatcttcagg aagaaagcac tccctacaag  10980

ccccagagcc cttcaatacc ctcatcccac ttgaggtttc agaaagcccc cgttgggcag  11040

catcttcctt ctgtgagccc ctcagtttct gatgctttcc tgcctcccag ctcccagcca  11100

gaggagtcat attgcttagt tgtcagcagt cccagtccca gctcccctca ttccccaggg  11160

ctctttccca gtacttccga gtatcctggg gactccaggg tccagaagaa gctgggcccc  11220

acaagtgctt tgttcgtgga cagggcctcc tccccaatcc tcactcttag tgccagcacc  11280

caagagccgg gtctttcccc aggctctttg accctctcag ccccttcaac tcaccctgtt  11340

gaaggccacc agaagcttga ctccagccca gaccctgttg atgccccaag gactccaatg  11400

gataattatt cccaaaccac tgacgagtta ggtggctccc agagaggtag aagttcctta  11460

caaaggagta atgggagatc cttccttgag ttgcactccc cacacagccc acagcagagt  11520

ccaaaactcc aatttagttt cttagggcag caccctcagc agcttcagcc caggacaact  11580

atcggggtcc aaagcagact gctgccacca ccactgaggc acaggagcca aaggctgggc  11640

aacagctttg tgcctgagaa ggtggcttcc ccggagcatt gcccactgag cggtagggag  11700

ccaagtcagt ggcagagcag gacagaaaat ggaggtgaga gttcagcatc tccaggggaa  11760

ccacaacgca ctctggaccg accttcttca tggggaggcc tccagcacct cagcccctgc  11820

cctgtctctg agttgactga tactgcaggg ctccgaggtt ctgccttggg cctccctcag  11880

gcctgccaac ctgaggagtt actgtgcttc agttgccaga tgtgcatggc ccctgagcac  11940

cagcaccaca gtctgaggga cctcccggtg cataacaaat ttagtaactg gtgtggggtt  12000

cagaagggct cacctggggg gttggacatg actgaggagg agctgggggc cagcggtgat  12060

ctcagctctg aaaagcagga acagagtccc ccacaacctc ctaatgacca cagccaggat  12120

tctgagtggt ccaagaggga gcagatcccc ctgcaagttg gggcccagaa cctctcactc  12180

agcgtggaac tcacagaagc gaaactgcac catggctttg gggaggccga tgccctgctc  12240

caggtgctgc agagtgggac aggggaggcg cttgctgctg atgaacctgt gacatccacc  12300

tggaaggagc tctatgcacg gcaaaaaaag gccattgaga ccctcaggag agagcgggct  12360

gagcgacttg ggaacttctg ccggacgcga agccttagcc ctcagaaaca actgagcctc  12420

ctgcccaaca aagatctctt catctgggat cttgacttgc ccagcagacg ccgagaatac  12480

ctgcagcaac tgaggaagga tgttgtggag accaccaggt acccagagtc agtgtcaagg  12540

tcagctcaca caccctctga catagagttg atgctgcaag actaccagca ggcccatgag  12600

gaggccaagg tggagattgc ccgggcccga gaccaactgc gggagcggac tgaacaagag  12660

aagctgagaa tccaccagaa gatcatttcc cagctattga aggaagagga taaactacat  12720

accttggcca attccagctc cctgtgcacc agctctaatg gaagcctctc gtctggcatg  12780

acctctggct ataatagcag cccagccttg tcaggccagc tccagttccc agagaatatg  12840

gggcatacaa acttgcctga ttccagggat gtatggatag gggatgagcg aggaggccat  12900

tctgcagtga ggaagaactc tgcctacagc cacagagcct ccctgggcag ttgctgctgt  12960

tcaccatcca gtctgtccag cttggggacc tgcttttcct cctcctacca ggatttggcc  13020

aagcatgtcg tggacacttc tatggctgat gtaatggctg cttgttcgga taatttgcac  13080

aacctcttca gctgccaggc aactgctggc tggaactatc agggtgagga gcaggcggtg  13140

cagctttact acaaggtgtt ttctcccact cggcatggct tcctgggggc aggtgtggtg  13200

tcccagccgc tgtctcgtgt gtgggcggct gtcagtgacc ccactgtgtg gcccctgtat  13260

tacaagccca tccagacagc aaggctgcat cagcgagtga ccaacagcat cagcctggtg  13320

tacttggtgt gcaacaccac cctgtgcgca ctgaagcagc cacgggattt ctgttgtgtc  13380

tgcgtggaag ccaaagaggg tcacctgtct gtcatggcag cccagtctgt gtatgataca  13440

tccatgccaa gacccagcag aaaaatggtt cgcggggaga tcctgcccag tgcctggatc  13500

ttgcagccca tcactgtgga agggaaggaa gtcaccagag tcatctactt ggcccaggtg  13560

gaacttggtg ctccaggctt cccacctcag ctcctgagct ctttcatcaa acggcagcca  13620

ctggttatag ccagactggc ttccttcctt ggtaggtagc atctcaccgt caagatggtg  13680

ctgctgagat gcaggcccag gctgctcaag agagacactg tggcagctcc ttgttacttt  13740

ccataccaca gtgcaggaaa agctgatgct acctgctgtg gccgattggg gcagacagca  13800

ctggcccagg gatgctagca aagcccagtc agtacttggt cacagctggc accagtgcag  13860

agcaaacggc ctgagctcct ggcccagact atccagagtg aatgcagctc cgctcacctt  13920

ttggatttct cacctttctt tcctgtttct gggactctgc ggcagacagg acacttaagg  13980

accaggactg ggcacagcca gcagagccgg ggactgcagt gctttggcaa ggtgcttccg  14040

caggctggta gggaagcagg cagccactgg ccaagactct gttctgaatc tacctcctct  14100

agcattcagc tctactgtgt gatgggacgt taaaaatacc aaaacagaaa gagggtttaa  14160

aaaacagctg cacaaaccag aacaccgatt cagaatcttt tctccctctt gagtttttgc  14220

aaaatacttt attattgatt tttgcttttt ttctcccttt ccctcccagg agaagacatt  14280

tgggtcttgg cctgaggcag gggtgttgag cgatgatgct ctgatatgga gctgtcactc  14340

tagagctcgg tcagatggaa gacactatag aaccaggttg gacagatttg gggtcagggt  14400

tggaggctga gttcttttga ggactggttg gagtggcagc cagatggtgg ctgctgacaa  14460

ggcaagagga atttcagaga ttaaacattg tcctttgagg aagggagagg aggtgaatga  14520

actcccagag gaggtgagtg gcttgttggg aggaagctca gttccagaac ttacctcagt  14580

gcacttggga ggggtggagt cctgagcatt ccatgatttc tgccctggcc ccacctatcc  14640

taggatgggg tgggatggag agtgggttca gttttcttgt actttagcct ggctgaacat  14700

gaactttgtg tttacctgga agtggtaggg gtgggagaga ttctcatctt tagttctggt  14760

gcccaaaatc tttggtagat ggagggaact ggggattcag aagatgtggt aaaggtctat  14820

ttctgtagtg tggcagagat gtgtttttct aaagtgtttg cagggcattt ttccctctta  14880

cctcagatta agttatttat atattgttga ttgaaggttt tttaaaattg cttttaaact  14940

tctatttctc gggtaaattt tttggtgaca tgatatattt aacaccctat ttatatactc  15000

ctacctcttt tcatataaat ctcttactaa gactactgac caaaaaagaa cattttaaaa  15060

ttaaaagtcc tctgtgtact tta                                          15083


<210>  1032
<211>  4552
<212>  PRT
<213>  Homo sapiens

<400>  1032

Met Arg Arg Arg Thr Thr Val Ile Phe Pro Leu Leu Leu Leu Leu Gln 
1               5                   10                  15


Val Phe Gln Asp Leu Gly Met Glu Val Leu Ser Gly Val Ala Lys Gly 
            20                  25                  30


Tyr Asn Ile Cys Leu Phe Ala Tyr Gly Gln Thr Gly Ser Gly Lys Thr 
        35                  40                  45


Tyr Thr Met Leu Gly Thr Pro Ala Ser Val Gly Leu Thr Pro Arg Ile 
    50                  55                  60


Cys Glu Gly Leu Phe Val Arg Glu Lys Asp Cys Ala Ser Leu Pro Ser 
65                  70                  75                  80


Ser Cys Arg Ile Lys Val Ser Phe Leu Glu Ile Tyr Asn Glu Arg Val 
                85                  90                  95


Arg Asp Leu Leu Lys Gln Ser Gly Gln Lys Lys Ser Tyr Thr Leu Arg 
            100                 105                 110


Val Arg Glu His Pro Glu Met Gly Pro Tyr Val Gln Gly Leu Ser Gln 
        115                 120                 125


His Val Val Thr Asn Tyr Lys Gln Val Ile Gln Leu Leu Glu Glu Gly 
    130                 135                 140


Ile Ala Asn Arg Ile Thr Ala Ala Thr His Val His Glu Ala Ser Ser 
145                 150                 155                 160


Arg Ser His Ala Ile Phe Thr Ile His Tyr Thr Gln Ala Ile Leu Glu 
                165                 170                 175


Asn Asn Leu Pro Ser Glu Met Ala Ser Lys Ile Asn Leu Val Asp Leu 
            180                 185                 190


Ala Gly Ser Glu Arg Ala Asp Pro Ser Tyr Cys Lys Asp Arg Ile Ala 
        195                 200                 205


Glu Gly Ala Asn Ile Asn Lys Ser Leu Val Thr Leu Gly Ile Val Ile 
    210                 215                 220


Ser Thr Leu Ala Gln Asn Ser Gln Val Phe Ser Ser Cys Gln Ser Leu 
225                 230                 235                 240


Asn Ser Ser Val Ser Asn Gly Gly Asp Ser Gly Ile Leu Ser Ser Pro 
                245                 250                 255


Ser Gly Thr Ser Ser Gly Gly Ala Pro Ser Arg Arg Gln Ser Tyr Ile 
            260                 265                 270


Pro Tyr Arg Asp Ser Val Leu Thr Trp Leu Leu Lys Asp Ser Leu Gly 
        275                 280                 285


Gly Asn Ser Lys Thr Ile Met Val Ala Ile Thr Arg Gln Thr Met Ser 
    290                 295                 300


Thr Leu Arg Tyr Ala Ser Ser Ala Lys Asn Ile Ile Asn Lys Pro Arg 
305                 310                 315                 320


Val Asn Glu Val Arg Pro Phe Gln Lys Asn Phe Ser Ser Leu Ser Asp 
                325                 330                 335


Glu Asn Leu Lys Glu Leu Val Leu Gln Asn Glu Leu Lys Val Asp Gln 
            340                 345                 350


Leu Thr Lys Asp Trp Thr Gln Lys Trp Asn Asp Trp Gln Ala Leu Met 
        355                 360                 365


Glu His Tyr Ser Val Asp Ile Asn Arg Arg Arg Ala Gly Val Val Ile 
    370                 375                 380


Asp Ser Ser Leu Pro His Leu Met Ala Leu Glu Asp Asp Val Leu Ser 
385                 390                 395                 400


Thr Gly Val Val Leu Tyr His Leu Lys Gly Gln Trp Ile Glu Arg Asp 
                405                 410                 415


His Cys Thr Ile Thr Ser Ala Cys Gly Val Val Val Leu Arg Pro Ala 
            420                 425                 430


Arg Gly Ala Arg Cys Thr Val Asn Gly Arg Glu Val Thr Ala Ser Cys 
        435                 440                 445


Arg Leu Thr Gln Gly Ala Val Ile Thr Leu Gly Lys Ala Gln Lys Phe 
    450                 455                 460


Arg Phe Asn His Pro Ala Glu Ala Ala Val Leu Arg Gln Arg Arg Gln 
465                 470                 475                 480


Val Gly Glu Ala Ala Ala Gly Arg Gly Ser Leu Glu Trp Leu Asp Leu 
                485                 490                 495


Asp Gly Asp Leu Ala Ala Ser Arg Leu Gly Leu Ser Pro Leu Leu Trp 
            500                 505                 510


Lys Glu Arg Arg Ala Leu Glu Glu Gln Cys Asp Glu Asp His Gln Thr 
        515                 520                 525


Pro Arg Asp Gly Glu Thr Ser His Arg Ala Gln Ile Gln Gln Gln Gln 
    530                 535                 540


Ser Tyr Val Glu Asp Leu Arg His Gln Ile Leu Ala Glu Glu Ile Arg 
545                 550                 555                 560


Ala Ala Lys Glu Leu Glu Phe Asp Gln Ala Trp Ile Ser Gln Gln Ile 
                565                 570                 575


Lys Glu Asn Gln Gln Cys Leu Leu Arg Glu Glu Thr Trp Leu Ala Ser 
            580                 585                 590


Leu Gln Gln Gln Gln Gln Glu Asp Gln Val Ala Glu Lys Glu Leu Glu 
        595                 600                 605


Ala Ser Val Ala Leu Asp Ala Trp Leu Gln Thr Asp Pro Glu Ile Gln 
    610                 615                 620


Pro Ser Pro Phe Val Gln Ser Gln Lys Arg Val Val His Leu Gln Leu 
625                 630                 635                 640


Leu Arg Arg His Thr Leu Arg Ala Ala Glu Arg Asn Val Arg Arg Lys 
                645                 650                 655


Lys Val Ser Phe Gln Leu Glu Arg Ile Ile Lys Lys Gln Arg Leu Leu 
            660                 665                 670


Glu Ala Gln Lys Arg Leu Glu Lys Leu Thr Thr Leu Cys Trp Leu Gln 
        675                 680                 685


Asp Asp Ser Thr Gln Glu Pro Pro Tyr Gln Val Leu Ser Pro Asp Ala 
    690                 695                 700


Thr Val Pro Arg Pro Pro Cys Arg Ser Lys Leu Thr Ser Cys Ser Ser 
705                 710                 715                 720


Leu Ser Pro Gln Arg Leu Cys Ser Lys His Met Pro Gln Leu His Ser 
                725                 730                 735


Ile Phe Leu Ser Trp Asp Pro Ser Thr Thr Leu Pro Pro Arg Pro Asp 
            740                 745                 750


Pro Thr His Gln Thr Ser Glu Lys Thr Ser Ser Glu Glu His Leu Pro 
        755                 760                 765


Gln Ala Ala Ser Tyr Pro Ala Arg Thr Gly Cys Leu Arg Lys Asn Gly 
    770                 775                 780


Leu His Ser Ser Gly His Gly Gln Pro Cys Thr Ala Arg Ala Ala Leu 
785                 790                 795                 800


Ala Arg Lys Gly Ala Ser Ala Pro Asp Ala Cys Leu Thr Met Ser Pro 
                805                 810                 815


Asn Ser Val Gly Ile Gln Glu Met Glu Met Gly Val Lys Gln Pro His 
            820                 825                 830


Gln Met Val Ser Gln Gly Leu Ala Ser Leu Arg Lys Ser Ala Asn Lys 
        835                 840                 845


Leu Lys Pro Arg His Glu Pro Lys Ile Phe Thr Ser Thr Thr Gln Thr 
    850                 855                 860


Arg Gly Ala Lys Gly Leu Ala Asp Pro Ser His Thr Gln Ala Gly Trp 
865                 870                 875                 880


Arg Lys Glu Gly Asn Leu Gly Thr His Lys Ala Ala Lys Gly Ala Ser 
                885                 890                 895


Cys Asn Ser Leu Tyr Pro His Gly Pro Arg Gln Thr Ala Gly His Gly 
            900                 905                 910


Lys Ala Val Lys Thr Phe Trp Thr Glu Tyr Lys Pro Pro Ser Pro Ser 
        915                 920                 925


Arg Ala Ser Lys Arg His Gln Arg Val Leu Ala Thr Arg Val Arg Asn 
    930                 935                 940


Ile Thr Lys Lys Ser Ser His Leu Pro Leu Gly Ser Pro Leu Lys Arg 
945                 950                 955                 960


Gln Gln Asn Thr Arg Asp Pro Asp Thr Met Val Pro Leu Thr Asp Phe 
                965                 970                 975


Ser Pro Val Met Asp His Ser Arg Glu Lys Asp Asn Asp Leu Ser Asp 
            980                 985                 990


Thr Asp Ser Asn Tyr Ser Leu Asp Ser Leu Ser Cys Val Tyr Ala Lys 
        995                 1000                1005


Ala Leu Ile Glu Pro Leu Lys Pro Glu Glu Arg Lys Trp Asp Phe Pro 
    1010                1015                1020


Glu Pro Glu Asn Ser Glu Ser Asp Asp Ser Gln Leu Ser Glu Asp Ser 
1025                1030                1035                1040


Leu Ala Glu Lys Arg Tyr Gln Ser Pro Lys Asn Arg Leu Gly Gly Asn 
                1045                1050                1055


Arg Pro Thr Asn Asn Arg Gly Gln Pro Arg Thr Arg Thr Arg Ala Ser 
            1060                1065                1070


Val Arg Gly Phe Thr Ala Ala Ser Asp Ser Asp Leu Leu Ala Gln Thr 
        1075                1080                1085


His Arg Ser Phe Ser Leu Asp Ser Leu Ile Asp Ala Glu Glu Glu Leu 
    1090                1095                1100


Gly Glu Asp Gln Gln Glu Glu Pro Phe Pro Gly Ser Ala Asp Glu Ile 
1105                1110                1115                1120


Pro Thr Glu Thr Phe Trp His Leu Glu Asp Ser Ser Leu Pro Val Met 
                1125                1130                1135


Asp Gln Glu Ala Ile Cys Arg Leu Gly Pro Ile Asn Tyr Arg Thr Ala 
            1140                1145                1150


Ala Arg Leu Asp Ala Val Leu Pro Met Ser Ser Ser Phe Tyr Leu Asp 
        1155                1160                1165


Pro Gln Phe Gln Pro His Cys Met Gln Leu Ser Arg Glu Ser Pro Leu 
    1170                1175                1180


Met Ser Met Asp Ser Trp Phe Ser Cys Asp Ser Lys Ile Asn Pro Ser 
1185                1190                1195                1200


Ser Pro Pro Gly Ile Val Gly Ser Leu Cys Pro Ser Pro Asp Met Gln 
                1205                1210                1215


Glu Phe His Ser Cys Lys Gly Glu Arg Pro Gly Tyr Trp Pro Asn Thr 
            1220                1225                1230


Glu Glu Leu Lys Pro Ser Asp Ala Glu Thr Val Leu Pro Tyr Ser Ser 
        1235                1240                1245


Lys Leu His Gln Gly Ser Thr Glu Leu Leu Cys Ser Ala Arg Asp Glu 
    1250                1255                1260


His Thr Ala Ser Ala Ala Asp Thr Ser Arg Leu Ser Leu Trp Gly Ile 
1265                1270                1275                1280


Gln Arg Leu Ile Gln Pro Gly Ala Asp Gly Thr Phe Gln Gly Arg Cys 
                1285                1290                1295


Ile Pro Asp Met Thr Gln Gln Gly Ser Ser Glu Ala Ser His Asn Ser 
            1300                1305                1310


Ser Val Ser Asn Val Leu Ala Ala Ser Ala Thr Thr Leu Thr His Val 
        1315                1320                1325


Gly Ser Thr His Glu Arg Asp Trp Ser Ala Leu Gln Gln Lys Tyr Leu 
    1330                1335                1340


Leu Glu Leu Ser Cys Pro Val Leu Glu Ala Ile Gly Ala Pro Lys Pro 
1345                1350                1355                1360


Ala Tyr Pro Tyr Leu Glu Glu Asp Ser Gly Ser Leu Ala Gln Ala Ser 
                1365                1370                1375


Ser Lys Gly Gly Asp Thr Leu Leu Pro Val Gly Pro Arg Val Ser Ser 
            1380                1385                1390


Asn Leu Asn Leu Asn Asn Phe Pro Val His Leu Ser Arg Ile Arg Arg 
        1395                1400                1405


Leu Arg Ala Glu Lys Glu Gln Asp Ser Leu Asn Ala Lys Leu Glu Gly 
    1410                1415                1420


Val Ser Asp Phe Phe Ser Thr Ser Glu Lys Glu Ala Ser Tyr Asp Glu 
1425                1430                1435                1440


Thr Tyr Ser Ala Asp Leu Glu Ser Leu Ser Ala Ser Arg Ser Thr Asn 
                1445                1450                1455


Ala Gln Val Phe Ala Thr Glu Asn Ala Ile Pro Asp Ser Met Thr Glu 
            1460                1465                1470


Ala Cys Glu Val Lys Gln Asn Asn Leu Glu Glu Cys Leu Gln Ser Cys 
        1475                1480                1485


Arg Lys Pro Gly Leu Met Thr Ser Ser Asp Glu Asp Phe Phe Gln Lys 
    1490                1495                1500


Asn Ala Cys His Ser Asn Val Thr Thr Ala Thr Lys Ala Asp His Trp 
1505                1510                1515                1520


Ser Gln Gly Trp Ala Pro Leu Arg Lys Asn Ser Ala Val Gln Pro Gly 
                1525                1530                1535


Gln Leu Ser Pro Asp Ser His Tyr Pro Leu Glu Glu Glu Lys Thr Asp 
            1540                1545                1550


Cys Gln Glu Ser Ser Lys Glu Ala Val Arg Arg His Ile Asn Val Ser 
        1555                1560                1565


Phe Ala Leu Pro Ser Gly Pro Glu Leu Tyr Leu His Ser Ala Pro Trp 
    1570                1575                1580


Asn Pro Leu Ser Ser Ser Leu Gln Pro Pro Leu Leu Glu Thr Phe Tyr 
1585                1590                1595                1600


Val Thr Lys Ser Arg Asp Ala Leu Thr Glu Thr Ala Leu Glu Ile Pro 
                1605                1610                1615


Ala Cys Arg Glu Val Arg Val Pro Ser Pro Pro Pro Arg Glu Ala Trp 
            1620                1625                1630


Gly Phe Gly His Asn His Gln Ala Leu Gln Gly Ala Tyr Leu Lys Asn 
        1635                1640                1645


Asn Leu Pro Val Leu Leu Gln Asn Gln Asn Ser Lys Ile Ala Ser Ser 
    1650                1655                1660


Gln Gln Val Thr Ala Glu Ile Pro Val Asp Leu Asn Thr Arg Glu Val 
1665                1670                1675                1680


Ile Arg Glu Ser Gly Lys Cys Pro Gly Asn Ile Thr Glu Glu Ser His 
                1685                1690                1695


Asp Ser Val Tyr Ser Ser Val Thr Gln Asn Arg His Phe Leu Pro Ser 
            1700                1705                1710


Thr Ser Thr Lys Val Cys Glu Phe Glu Asn Gln Val Val Ile Leu Asn 
        1715                1720                1725


Lys Lys His Ser Phe Pro Ala Leu Glu Gly Gly Glu Val Thr Ala Gln 
    1730                1735                1740


Ser Cys Cys Gly Ala Ser Ser Asp Ser Thr Glu Ser Gly Lys Ser Leu 
1745                1750                1755                1760


Leu Phe Arg Glu Ser Glu Ala Arg Glu Glu Glu Glu Leu Asp Gln Asn 
                1765                1770                1775


Thr Val Leu Arg Gln Thr Ile Asn Val Ser Leu Glu Lys Asp Met Pro 
            1780                1785                1790


Gly Glu Ser Ala Val Ser Leu Lys Ser Arg Ser Val Asp Arg Arg Val 
        1795                1800                1805


Ser Ser Pro Val Met Val Ala Gln Gly Gly Gly Pro Thr Pro Lys Trp 
    1810                1815                1820


Glu Gly Lys Asn Glu Thr Gly Leu Leu Glu Lys Gly Leu Arg Pro Lys 
1825                1830                1835                1840


Asp Ser Ser Glu Glu Phe Lys Leu Pro Gly Thr Lys Pro Ala Tyr Glu 
                1845                1850                1855


Arg Phe Gln Leu Val Ala Cys Pro Gln Glu Arg Asn Pro Ser Glu Cys 
            1860                1865                1870


Lys Ser Gln Glu Met Leu Asn Pro Asn Arg Glu Pro Ser Gly Lys Lys 
        1875                1880                1885


Gln Asn Lys Arg Val Asn Asn Thr Asp Glu Met Ala Arg Leu Ile Arg 
    1890                1895                1900


Ser Val Met Gln Leu Glu Asn Gly Ile Leu Glu Ile Glu Ser Lys Gln 
1905                1910                1915                1920


Asn Lys Gln Val His Ala Ser His Thr Pro Gly Thr Asp Lys Glu Leu 
                1925                1930                1935


Val Phe Gln Asp Gln Lys Glu Gln Glu Lys Thr Asp His Ala Phe Arg 
            1940                1945                1950


Pro Asp Ser Ser Gly Asn Pro Leu Pro Ser Lys Asp Gln Pro Ser Ser 
        1955                1960                1965


Pro Arg Gln Thr Asp Asp Thr Val Phe Arg Asp Ser Glu Ala Gly Ala 
    1970                1975                1980


Met Glu Val Asn Ser Ile Gly Asn His Pro Gln Val Gln Lys Ile Thr 
1985                1990                1995                2000


Pro Asn Pro Phe Arg Ser Arg Glu Gly Val Arg Glu Ser Glu Pro Val 
                2005                2010                2015


Arg Glu His Thr His Pro Ala Gly Ser Asp Arg Pro Ala Arg Asp Ile 
            2020                2025                2030


Cys Asp Ser Leu Gly Lys His Thr Thr Cys Arg Glu Phe Thr Asn Thr 
        2035                2040                2045


Ser Leu His Pro Gln Arg Met Lys Ala Leu Ala Arg Ala Leu Pro Leu 
    2050                2055                2060


Gln Pro Arg Leu Glu Arg Ser Ser Lys Asn Asn Gly Gln Phe Val Lys 
2065                2070                2075                2080


Ala Ser Ala Ser Leu Lys Gly Gln Pro Trp Gly Leu Gly Ser Leu Glu 
                2085                2090                2095


Glu Leu Glu Thr Val Lys Gly Phe Gln Glu Ser Gln Val Ala Glu His 
            2100                2105                2110


Val Ser Ser Ser Asn Gln Glu Glu Pro Lys Ala Gln Gly Lys Val Glu 
        2115                2120                2125


Glu Met Pro Met Gln Arg Gly Gly Ser Leu Gln Glu Glu Asn Lys Val 
    2130                2135                2140


Thr Gln Lys Phe Pro Ser Leu Ser Gln Leu Cys Arg Asp Thr Phe Phe 
2145                2150                2155                2160


Arg Gln Glu Thr Val Ser Pro Leu Leu Ser Arg Thr Glu Phe Cys Thr 
                2165                2170                2175


Ala Pro Leu His Gln Asp Leu Ser Asn Thr Leu Pro Leu Asn Ser Pro 
            2180                2185                2190


Arg Trp Pro Arg Arg Cys Leu His Val Pro Val Ala Leu Gly Ile Ser 
        2195                2200                2205


Ser Leu Asp Cys Val Leu Asp Leu Thr Met Leu Lys Ile His Asn Ser 
    2210                2215                2220


Pro Leu Val Thr Gly Val Glu His Gln Asp Gln Ser Thr Glu Thr Arg 
2225                2230                2235                2240


Ser His Ser Pro Glu Gly Asn Val Arg Gly Arg Ser Ser Glu Ala His 
                2245                2250                2255


Thr Ala Trp Cys Gly Ser Val Arg Ser Met Ala Met Gly Ser His Ser 
            2260                2265                2270


Gln Ser Gly Val Pro Glu Ser Ile Pro Leu Gly Thr Glu Asp Arg Ile 
        2275                2280                2285


Ser Ala Ser Thr Ser Pro Gln Asp His Gly Lys Asp Leu Arg Ile Thr 
    2290                2295                2300


Leu Leu Gly Phe Ser Thr Ser Glu Asp Phe Ala Ser Glu Ala Glu Val 
2305                2310                2315                2320


Ala Val Gln Lys Glu Ile Arg Val Ser Ser Leu Asn Lys Val Ser Ser 
                2325                2330                2335


Gln Pro Glu Lys Arg Val Ser Phe Ser Leu Glu Glu Asp Ser Asp Gln 
            2340                2345                2350


Ala Ser Lys Pro Arg Gln Lys Ala Glu Lys Glu Thr Glu Asp Val Gly 
        2355                2360                2365


Leu Thr Ser Gly Val Ser Leu Ala Pro Val Ser Leu Pro Arg Val Pro 
    2370                2375                2380


Ser Pro Glu Pro Arg Leu Leu Glu Pro Ser Asp His Ala Ser Met Cys 
2385                2390                2395                2400


Leu Ala Ile Leu Glu Glu Ile Arg Gln Ala Lys Ala Gln Arg Lys Gln 
                2405                2410                2415


Leu His Asp Phe Val Ala Arg Gly Thr Val Leu Ser Tyr Cys Glu Thr 
            2420                2425                2430


Leu Leu Glu Pro Glu Cys Ser Ser Arg Val Ala Gly Arg Pro Gln Cys 
        2435                2440                2445


Lys Gln Ile Asp Gln Ser Ser Ser Asp Gln Thr Arg Asn Glu Gly Glu 
    2450                2455                2460


Ala Pro Gly Phe His Val Ala Ser Leu Ser Ala Glu Ala Gly Gln Ile 
2465                2470                2475                2480


Asp Leu Leu Pro Asp Glu Arg Lys Val Gln Ala Thr Ser Leu Ser Ala 
                2485                2490                2495


Asp Ser Phe Glu Ser Leu Pro Asn Thr Glu Thr Asp Arg Glu Pro Trp 
            2500                2505                2510


Asp Pro Val Gln Ala Phe Ser His Ala Ala Pro Ala Gln Asp Arg Lys 
        2515                2520                2525


Arg Arg Thr Gly Glu Leu Arg Gln Phe Ala Gly Ala Ser Glu Pro Phe 
    2530                2535                2540


Ile Cys His Ser Ser Ser Ser Glu Ile Ile Glu Lys Lys Lys Asp Ala 
2545                2550                2555                2560


Thr Arg Thr Pro Ser Ser Ala Asp Pro Leu Ala Pro Asp Ser Pro Arg 
                2565                2570                2575


Ser Ser Ala Pro Val Glu Glu Val Arg Arg Val Val Ser Lys Lys Val 
            2580                2585                2590


Val Ala Ala Leu Pro Ser Gln Ala Pro Tyr Asp Asp Pro Arg Val Thr 
        2595                2600                2605


Leu His Glu Leu Ser Gln Ser Val Pro Gln Glu Thr Ala Glu Gly Ile 
    2610                2615                2620


Pro Pro Gly Ser Gln Asp Ser Ser Pro Glu His Gln Glu Pro Arg Thr 
2625                2630                2635                2640


Leu Asp Thr Thr Tyr Gly Glu Val Ser Asp Asn Leu Leu Val Thr Ala 
                2645                2650                2655


Gln Gly Glu Lys Thr Ala His Phe Glu Ser Gln Ser Val Thr Cys Asp 
            2660                2665                2670


Val Gln Asn Ser Thr Ser Ala Ser Gly Pro Lys Gln Asp His Val Gln 
        2675                2680                2685


Cys Pro Glu Ala Ser Thr Gly Phe Glu Glu Gly Arg Ala Ser Pro Lys 
    2690                2695                2700


Gln Asp Thr Ile Leu Pro Gly Ala Leu Thr Arg Val Ala Leu Glu Ala 
2705                2710                2715                2720


Pro Thr Gln Gln Cys Val Gln Cys Lys Glu Ser Val Gly Ser Gly Leu 
                2725                2730                2735


Thr Glu Val Cys Arg Ala Gly Ser Lys His Ser Arg Pro Ile Pro Leu 
            2740                2745                2750


Pro Asp Gln Arg Pro Ser Ala Asn Pro Gly Gly Ile Gly Glu Glu Ala 
        2755                2760                2765


Pro Cys Arg His Pro Arg Glu Ala Leu Asp Gly Pro Val Phe Ser Arg 
    2770                2775                2780


Asn Pro Glu Gly Ser Arg Thr Leu Ser Pro Ser Arg Gly Lys Glu Ser 
2785                2790                2795                2800


Arg Thr Leu Pro Cys Arg Gln Pro Cys Ser Ser Gln Pro Val Ala Thr 
                2805                2810                2815


His Ala Tyr Ser Ser His Ser Ser Thr Leu Leu Cys Phe Arg Asp Gly 
            2820                2825                2830


Asp Leu Gly Lys Glu Pro Phe Lys Ala Ala Pro His Thr Ile His Pro 
        2835                2840                2845


Pro Cys Val Val Pro Ser Arg Ala Tyr Glu Met Asp Glu Thr Gly Glu 
    2850                2855                2860


Ile Ser Arg Gly Pro Asp Val His Leu Thr His Gly Leu Glu Pro Lys 
2865                2870                2875                2880


Asp Val Asn Arg Glu Phe Arg Leu Thr Glu Ser Ser Thr Cys Glu Pro 
                2885                2890                2895


Ser Thr Val Ala Ala Val Leu Ser Arg Ala Gln Gly Cys Arg Ser Pro 
            2900                2905                2910


Ser Ala Pro Asp Val Arg Thr Gly Ser Phe Ser His Ser Ala Thr Asp 
        2915                2920                2925


Gly Ser Val Gly Leu Ile Gly Val Pro Glu Lys Lys Val Ala Glu Lys 
    2930                2935                2940


Gln Ala Ser Thr Glu Leu Glu Ala Ala Ser Phe Pro Ala Gly Met Tyr 
2945                2950                2955                2960


Ser Glu Pro Leu Arg Gln Phe Arg Asp Ser Ser Val Gly Asp Gln Asn 
                2965                2970                2975


Ala Gln Val Cys Gln Thr Asn Pro Glu Pro Pro Ala Thr Thr Gln Gly 
            2980                2985                2990


Pro His Thr Leu Asp Leu Ser Glu Gly Ser Ala Glu Ser Lys Leu Val 
        2995                3000                3005


Val Glu Pro Gln His Glu Cys Leu Glu Asn Thr Thr Arg Cys Phe Leu 
    3010                3015                3020


Glu Lys Pro Gln Phe Ser Thr Glu Leu Arg Asp His Asn Arg Leu Asp 
3025                3030                3035                3040


Ser Gln Ala Lys Phe Val Ala Arg Leu Lys His Thr Cys Ser Pro Gln 
                3045                3050                3055


Glu Asp Ser Pro Trp Gln Glu Glu Glu Gln His Arg Asp Gln Ala Ser 
            3060                3065                3070


Gly Gly Gly Glu Gly Phe Ala Gln Gly Val Asn Pro Leu Pro Asp Glu 
        3075                3080                3085


Asp Gly Leu Asp Gly Cys Gln Ile Leu Asp Ala Gly Arg Glu Glu Val 
    3090                3095                3100


Ala Val Ala Lys Pro Pro Val Ser Lys Ile Leu Ser Gln Gly Phe Lys 
3105                3110                3115                3120


Asp Pro Ala Thr Val Ser Leu Arg Gln Asn Glu Thr Pro Gln Pro Ala 
                3125                3130                3135


Ala Gln Arg Ser Gly His Leu Tyr Thr Gly Arg Glu Gln Pro Ala Pro 
            3140                3145                3150


Asn His Arg Gly Ser Leu Pro Val Thr Thr Ile Phe Ser Gly Pro Lys 
        3155                3160                3165


His Ser Arg Ser Ser Pro Thr Pro Gln Phe Ser Val Val Gly Ser Ser 
    3170                3175                3180


Arg Ser Leu Gln Glu Leu Asn Leu Ser Val Glu Pro Pro Ser Pro Thr 
3185                3190                3195                3200


Asp Glu Asp Thr Gln Gly Pro Asn Arg Leu Trp Asn Pro His Leu Arg 
                3205                3210                3215


Gly Tyr Ser Ser Gly Lys Ser Val Ala Arg Thr Ser Leu Gln Ala Glu 
            3220                3225                3230


Asp Ser Asn Gln Lys Ala Ser Ser Arg Leu Asp Asp Gly Thr Thr Asp 
        3235                3240                3245


His Arg His Leu Lys Pro Ala Thr Pro Pro Tyr Pro Met Pro Ser Thr 
    3250                3255                3260


Leu Ser His Met Pro Thr Pro Asp Phe Thr Thr Ser Trp Met Ser Gly 
3265                3270                3275                3280


Thr Leu Glu Gln Ala Gln Gln Gly Lys Arg Glu Lys Leu Gly Val Gln 
                3285                3290                3295


Val Arg Pro Glu Asn Trp Cys Ser Gln Met Asp Lys Gly Met Leu His 
            3300                3305                3310


Phe Gly Ser Ser Asp Ile Ser Pro Tyr Ala Leu Pro Trp Arg Pro Glu 
        3315                3320                3325


Glu Pro Ala Arg Ile Ser Trp Lys Gln Tyr Met Ser Gly Ser Ala Val 
    3330                3335                3340


Asp Val Ser Cys Ser Gln Lys Pro Gln Gly Leu Thr Leu Ser Asn Val 
3345                3350                3355                3360


Ala Arg Cys Ser Ser Met Asp Asn Gly Leu Glu Asp Gln Asn Ser Pro 
                3365                3370                3375


Phe His Ser His Leu Ser Thr Tyr Ala Asn Ile Cys Asp Leu Ser Thr 
            3380                3385                3390


Thr His Ser Ser Thr Glu Asn Ala Gln Gly Ser Asn Glu Ala Trp Glu 
        3395                3400                3405


Val Phe Arg Gly Ser Ser Ser Ile Ala Leu Gly Asp Pro His Ile Pro 
    3410                3415                3420


Thr Ser Pro Glu Gly Val Ala Pro Thr Ser Gly His Asp Arg Arg Pro 
3425                3430                3435                3440


Gln Phe Arg Gly Pro Ser Gly Glu Ala Asp Cys Leu Arg Ser Lys Pro 
                3445                3450                3455


Pro Leu Ala Lys Gly Ser Ala Ala Gly Pro Val Asp Glu Ile Met Leu 
            3460                3465                3470


Leu Tyr Pro Ser Glu Ala Gly Cys Pro Val Gly Gln Thr Arg Thr Asn 
        3475                3480                3485


Thr Phe Glu Gln Gly Thr Gln Thr Leu Gly Ser Arg Arg His Trp Ser 
    3490                3495                3500


Ser Thr Asp Ile Ser Phe Ala Gln Pro Glu Ala Ser Ala Val Ser Ala 
3505                3510                3515                3520


Phe Asp Leu Ala Ser Trp Thr Ser Met His Asn Leu Ser Leu His Leu 
                3525                3530                3535


Ser Gln Leu Leu His Ser Thr Ser Glu Leu Leu Gly Ser Leu Ser Gln 
            3540                3545                3550


Pro Asp Val Ala Arg Arg Glu Gln Asn Thr Lys Arg Asp Ile Pro Asp 
        3555                3560                3565


Lys Ala Pro Gln Ala Leu Met Met Asp Gly Ser Thr Gln Thr Thr Val 
    3570                3575                3580


Asp Glu Gly Ser Gln Thr Asp Leu Thr Leu Pro Thr Leu Cys Leu Gln 
3585                3590                3595                3600


Thr Ser Glu Ala Glu Pro Gln Gly Ala Asn Val Ile Leu Glu Gly Leu 
                3605                3610                3615


Gly Ser Asp Thr Ser Thr Val Ser Gln Glu Glu Gly Asp Val Pro Gly 
            3620                3625                3630


Val Pro Gln Lys Arg Glu Ala Glu Glu Thr Ala Gln Lys Met Ala Gln 
        3635                3640                3645


Leu Leu Tyr Leu Gln Glu Glu Ser Thr Pro Tyr Lys Pro Gln Ser Pro 
    3650                3655                3660


Ser Ile Pro Ser Ser His Leu Arg Phe Gln Lys Ala Pro Val Gly Gln 
3665                3670                3675                3680


His Leu Pro Ser Val Ser Pro Ser Val Ser Asp Ala Phe Leu Pro Pro 
                3685                3690                3695


Ser Ser Gln Pro Glu Glu Ser Tyr Cys Leu Val Val Ser Ser Pro Ser 
            3700                3705                3710


Pro Ser Ser Pro His Ser Pro Gly Leu Phe Pro Ser Thr Ser Glu Tyr 
        3715                3720                3725


Pro Gly Asp Ser Arg Val Gln Lys Lys Leu Gly Pro Thr Ser Ala Leu 
    3730                3735                3740


Phe Val Asp Arg Ala Ser Ser Pro Ile Leu Thr Leu Ser Ala Ser Thr 
3745                3750                3755                3760


Gln Glu Pro Gly Leu Ser Pro Gly Ser Leu Thr Leu Ser Ala Pro Ser 
                3765                3770                3775


Thr His Pro Val Glu Gly His Gln Lys Leu Asp Ser Ser Pro Asp Pro 
            3780                3785                3790


Val Asp Ala Pro Arg Thr Pro Met Asp Asn Tyr Ser Gln Thr Thr Asp 
        3795                3800                3805


Glu Leu Gly Gly Ser Gln Arg Gly Arg Ser Ser Leu Gln Arg Ser Asn 
    3810                3815                3820


Gly Arg Ser Phe Leu Glu Leu His Ser Pro His Ser Pro Gln Gln Ser 
3825                3830                3835                3840


Pro Lys Leu Gln Phe Ser Phe Leu Gly Gln His Pro Gln Gln Leu Gln 
                3845                3850                3855


Pro Arg Thr Thr Ile Gly Val Gln Ser Arg Leu Leu Pro Pro Pro Leu 
            3860                3865                3870


Arg His Arg Ser Gln Arg Leu Gly Asn Ser Phe Val Pro Glu Lys Val 
        3875                3880                3885


Ala Ser Pro Glu His Cys Pro Leu Ser Gly Arg Glu Pro Ser Gln Trp 
    3890                3895                3900


Gln Ser Arg Thr Glu Asn Gly Gly Glu Ser Ser Ala Ser Pro Gly Glu 
3905                3910                3915                3920


Pro Gln Arg Thr Leu Asp Arg Pro Ser Ser Trp Gly Gly Leu Gln His 
                3925                3930                3935


Leu Ser Pro Cys Pro Val Ser Glu Leu Thr Asp Thr Ala Gly Leu Arg 
            3940                3945                3950


Gly Ser Ala Leu Gly Leu Pro Gln Ala Cys Gln Pro Glu Glu Leu Leu 
        3955                3960                3965


Cys Phe Ser Cys Gln Met Cys Met Ala Pro Glu His Gln His His Ser 
    3970                3975                3980


Leu Arg Asp Leu Pro Val His Asn Lys Phe Ser Asn Trp Cys Gly Val 
3985                3990                3995                4000


Gln Lys Gly Ser Pro Gly Gly Leu Asp Met Thr Glu Glu Glu Leu Gly 
                4005                4010                4015


Ala Ser Gly Asp Leu Ser Ser Glu Lys Gln Glu Gln Ser Pro Pro Gln 
            4020                4025                4030


Pro Pro Asn Asp His Ser Gln Asp Ser Glu Trp Ser Lys Arg Glu Gln 
        4035                4040                4045


Ile Pro Leu Gln Val Gly Ala Gln Asn Leu Ser Leu Ser Val Glu Leu 
    4050                4055                4060


Thr Glu Ala Lys Leu His His Gly Phe Gly Glu Ala Asp Ala Leu Leu 
4065                4070                4075                4080


Gln Val Leu Gln Ser Gly Thr Gly Glu Ala Leu Ala Ala Asp Glu Pro 
                4085                4090                4095


Val Thr Ser Thr Trp Lys Glu Leu Tyr Ala Arg Gln Lys Lys Ala Ile 
            4100                4105                4110


Glu Thr Leu Arg Arg Glu Arg Ala Glu Arg Leu Gly Asn Phe Cys Arg 
        4115                4120                4125


Thr Arg Ser Leu Ser Pro Gln Lys Gln Leu Ser Leu Leu Pro Asn Lys 
    4130                4135                4140


Asp Leu Phe Ile Trp Asp Leu Asp Leu Pro Ser Arg Arg Arg Glu Tyr 
4145                4150                4155                4160


Leu Gln Gln Leu Arg Lys Asp Val Val Glu Thr Thr Arg Tyr Pro Glu 
                4165                4170                4175


Ser Val Ser Arg Ser Ala His Thr Pro Ser Asp Ile Glu Leu Met Leu 
            4180                4185                4190


Gln Asp Tyr Gln Gln Ala His Glu Glu Ala Lys Val Glu Ile Ala Arg 
        4195                4200                4205


Ala Arg Asp Gln Leu Arg Glu Arg Thr Glu Gln Glu Lys Leu Arg Ile 
    4210                4215                4220


His Gln Lys Ile Ile Ser Gln Leu Leu Lys Glu Glu Asp Lys Leu His 
4225                4230                4235                4240


Thr Leu Ala Asn Ser Ser Ser Leu Cys Thr Ser Ser Asn Gly Ser Leu 
                4245                4250                4255


Ser Ser Gly Met Thr Ser Gly Tyr Asn Ser Ser Pro Ala Leu Ser Gly 
            4260                4265                4270


Gln Leu Gln Phe Pro Glu Asn Met Gly His Thr Asn Leu Pro Asp Ser 
        4275                4280                4285


Arg Asp Val Trp Ile Gly Asp Glu Arg Gly Gly His Ser Ala Val Arg 
    4290                4295                4300


Lys Asn Ser Ala Tyr Ser His Arg Ala Ser Leu Gly Ser Cys Cys Cys 
4305                4310                4315                4320


Ser Pro Ser Ser Leu Ser Ser Leu Gly Thr Cys Phe Ser Ser Ser Tyr 
                4325                4330                4335


Gln Asp Leu Ala Lys His Val Val Asp Thr Ser Met Ala Asp Val Met 
            4340                4345                4350


Ala Ala Cys Ser Asp Asn Leu His Asn Leu Phe Ser Cys Gln Ala Thr 
        4355                4360                4365


Ala Gly Trp Asn Tyr Gln Gly Glu Glu Gln Ala Val Gln Leu Tyr Tyr 
    4370                4375                4380


Lys Val Phe Ser Pro Thr Arg His Gly Phe Leu Gly Ala Gly Val Val 
4385                4390                4395                4400


Ser Gln Pro Leu Ser Arg Val Trp Ala Ala Val Ser Asp Pro Thr Val 
                4405                4410                4415


Trp Pro Leu Tyr Tyr Lys Pro Ile Gln Thr Ala Arg Leu His Gln Arg 
            4420                4425                4430


Val Thr Asn Ser Ile Ser Leu Val Tyr Leu Val Cys Asn Thr Thr Leu 
        4435                4440                4445


Cys Ala Leu Lys Gln Pro Arg Asp Phe Cys Cys Val Cys Val Glu Ala 
    4450                4455                4460


Lys Glu Gly His Leu Ser Val Met Ala Ala Gln Ser Val Tyr Asp Thr 
4465                4470                4475                4480


Ser Met Pro Arg Pro Ser Arg Lys Met Val Arg Gly Glu Ile Leu Pro 
                4485                4490                4495


Ser Ala Trp Ile Leu Gln Pro Ile Thr Val Glu Gly Lys Glu Val Thr 
            4500                4505                4510


Arg Val Ile Tyr Leu Ala Gln Val Glu Leu Gly Ala Pro Gly Phe Pro 
        4515                4520                4525


Pro Gln Leu Leu Ser Ser Phe Ile Lys Arg Gln Pro Leu Val Ile Ala 
    4530                4535                4540


Arg Leu Ala Ser Phe Leu Gly Arg 
4545                4550


<210>  1033
<211>  4757
<212>  DNA
<213>  Homo sapiens

<400>  1033
ccgggtccct ccccatcccg cgacccaacg gtcgttcccc gccgccggcc ccgcccctcc     60

ctggccgccc gcggcgcgcc ggcgcctgcg cagtcgcccc agagcgcccc gaccgggatg    120

gcggccgttt tggagtcgct gctgcgagaa gaggtgtcgg tcgcagccgt cgtgcggtgg    180

atcgcgcgca gcacccaggg ttcggaggat aacgctgggg aggcggccgc gctgagctca    240

ctccgggccc tgcggaaaga attcgtaccg ttcctgttga acttcctgag ggagcagagc    300

agccgcgtcc tcccgcaggg gcccccgacc cccgccaaga ccccgggcgc ctcggcagcc    360

ttgccaggga ggccgggagg cccgccgcgg ggtagccgcg gggcgcgcag ccagcttttc    420

cctccgaccg aggcccagag caccgctgcc gaggcccctc tggcccgccg cgggggcagg    480

aggcggggcc cggggccggc ccgcgagcgt ggaggccgcg gcctggagga gggggtcagc    540

ggggagagcc tgcccggagc cgggggccgg aggcttaggg gctctggcag ccccagccgc    600

cccagcctca cgctgtctga tccgccaaac ctcagcaacc tggaggagtt ccctcccgta    660

ggctcggttc cccccggccc tacagggacg aagccttctc gcaggatcaa cccaactccg    720

gtgagcgaag agcggtcact ctccaagccc aagacctgct tcacctcacc cccaatcagc    780

tgtgtcccca gttcccaacc ctcagccctg gacactagcc cttggggcct tggccttccc    840

ccagggtgca gaagtctgca agaggagcga gagatgctca ggaaggagcg ctctaagcag    900

ctgcagcagt cacctacccc cacctgtccc accccagaat tggggtcgcc cctccccagc    960

cggacaggaa gcctcacaga tgaacctgca gaccctgcca gagtgtcttc ccgccagcgc   1020

ctggagcttg tagcccttgt ttactcctcg tgcattgctg agaacctggt accaaacctc   1080

ttcttggagc ttttcttcgt ctttcagctc ctcactgccc ggaggatggt gactgccaag   1140

gacagcgacc ctgaactaag tccagctgtc ctagattccc tggaaagtcc actgttccaa   1200

agcatccacg attgtgtctt ctttgcagtg caggttttgg agtgtcactt tcaggttctt   1260

tccaacctgg acaaagggac cttgaagctg ctggctgaga atgagcggct gctgtgcttc   1320

tcaccagctc tgcaaggccg ccttcgagct gcctatgagg gcagtgttgc caaggtctct   1380

ctggtgatgc ctccctctac tcaagctgtc tcctttcagc cagagactga caatcgtgcc   1440

aacttctcca gtgaccgagc ctttcatact tttaagaaac agagggatgt gttttatgag   1500

gtgctgcgag agtgggaaga tcaccatgag gagcctggct gggattttga gaagggcttg   1560

ggcagcagaa tcagggccat gatgggtcag ctctccgcag cctgcagcca cagccacttt   1620

gttcggcttt tccaaaaaca actactccag atgtgtcaga gccctggtgg tgctgggggc   1680

accgtcttgg gcgaggcccc agatgtgttg agtatgctgg gagctgacaa gctggggcgg   1740

ttgtggcgcc tacaggaacg gcttatggct cctcagagca gtggggggcc ctgcccaccc   1800

cccaccttcc caggctgtca aggcttcttt agggacttca tccttagtgc cagcagcttc   1860

cagtttaacc agcatctcat ggacagtctg agcttgaaga tccaggagct caatggtctt   1920

gccctgcccc agcatgagcc caatgatgaa gacggggagt cagacgtaga ctggcagggt   1980

gagcggaagc aatttgctgt ggtgcttctt agcctgagac ttttggctaa attcctgggc   2040

tttgtggctt tcctgccata ccgggggcct gaacctcccc cgaccggtga gcttcaggac   2100

tccattctgg ccctcaggag ccaggtccct ccggtcctgg atgtgcggac tctgctgcag   2160

cgagggctgc aggcccgccg ggcggtgctc accgtgccct ggctggtgga gtttctctcc   2220

tttgctgacc atgttgttcc cttgctggaa tattaccggg acatcttcac tctcctgctg   2280

cgcctgcacc ggagcttggt gttgtcgcag gagagtgagg ggaagatgtg tttcctgaac   2340

aagctgctgc tacttgctgt cctgggctgg cttttccaga ttcccacagt ccctgaggac   2400

ttgttctttc tggaagaggg tccctcatat gcctttgagg tggacacagt agccccagag   2460

catggcttgg acaatgcgcc tgtggtggac cagcagctgc tctacacctg ctgcccctac   2520

atcggagagc tccggaaact gctcgcttcg tgggtgtcag gcagtagtgg acggagtggg   2580

ggcttcatga ggaaaatcac ccccaccact accaccagcc tgggagccca gccttcccag   2640

accagccagg ggctgcaggc acagctcgcc caggcctttt tccacaacca gccgccctcc   2700

ttgcgccgga ccgtagagtt cgtggcagaa agaattggat caaactgtgt caaacatatc   2760

aaggctacac tggtggcaga tctggtgcgc caggcagagt cacttctcca agagcagctg   2820

gtgacacagg gagaggaagg gggagaccca gcccagctgt tggagatctt gtgttcccag   2880

ctgtgccctc acggggccca ggcattggcc ctggggcggg agttctgtca aaggaagagc   2940

cctggggctg tgcgggcgct gcttccagag gagaccccgg cagccgttct gagcagtgca   3000

gagaacattg ctgtggggct tgcaacagag aaagcctgtg cttggctgtc agccaacatc   3060

acagcactga tcaggaggga ggtgaaagca gcagtgagtc gcacacttcg agcccagggt   3120

cctgaacctg ctgcccgggg ggagcggagg ggctgctccc gcgcctgtga gcaccatgct   3180

cccctcccct cccacctcat ctccgagata aaagacgtgc tctccttggc cgtggggcca   3240

cgggaccctg acgagggagt ctccccagag catctggaac agctcctagg ccagctgggc   3300

cagacgctgc ggtgccgcca gttcctgtgc ccacctgctg agcagcatct ggcaaagtgc   3360

tctgtggagt tagcttccct cctcgttgca gatcaaattc ctatcctagg gcccccggca   3420

cagtacaggc tggagagagg gcaggctcga aggcttctgc acatgctgct ttccttgtgg   3480

aaggaagact ttcaggggcc ggttccgctg cagctgctgc tgagcccaag aaatgtgggg   3540

cttctggcag acacaaggcc aagggagtgg gacttgctgc tattcttgct acgggagctg   3600

gtggagaagg gtctgatggg acggatggag atagaggcct gcctgggcag cctccaccag   3660

gcccagtggc caggggactt tgctgaagaa ttagcaacac tgtctaatct gtttctagcc   3720

gagccccacc tgccagaacc ccagctaaga gcctgtgagt tggtgcagcc aaaccggggc   3780

actgtgctgg cccagagcta gggctgagaa gtggccctgc cttgggcatt gcaccagaac   3840

cctggacccc cgcctcacga ggaggcccaa gtgcccaatg cagaccctca ctggttgggg   3900

tgtagctggg tctacagtca gacttcctgc tctaagggtg tcactgcctg gcatcccacc   3960

acgcgaatcc tagaggaagg agagttggcc tgatttggga ttatggcaga aaagtccaga   4020

gatgccagtc ctggagtaga agaggtggtg tttgtttatc tcttggatac taaatgaaat   4080

gaggtgtgtg ggcttgtcaa cacagaattc aagcctcatt tgctatccca gcatctctta   4140

aaactttgta gtcttggaat tcatgacaga ggcaaatgac tcctgcttaa cttatgaaga   4200

aagttaaaac atgaatcttg ggagtctaca ttttcttatc accaggagct ggactgccat   4260

ctccttataa atgcctaaca caggccgggt ctggtggctc atgcctgtaa tcccagcact   4320

ttgagaggcc tgaggtcggc ggactgcctg aggtcaggaa ttcaagacca gcctggccaa   4380

catggcaaaa ccccatctct actaaaaata aaaaaattat tagctgggca tggtggtgtg   4440

tgcctgtaat cccagctact caggaggatg aggcaggaga cctgcttgaa cctggaggtg   4500

gaggttgcag tgagccgagg tcgcaccact gcactccagt ctgggtaaca gagcgagact   4560

ttctagaaaa agcctaacaa acagataagg taggactcaa ccaactgaaa cctgactttc   4620

cccctgtacc ttcagcccct gtgcaggtag taacctcttg agacctctcc ctgaccaggg   4680

accaagcaca gggcatttag agctttttag aataaactgg ttttctttaa aaaaaaaaaa   4740

aaaaaaaaaa aaaaaaa                                                  4757


<210>  1034
<211>  1227
<212>  PRT
<213>  Homo sapiens

<400>  1034

Met Ala Ala Val Leu Glu Ser Leu Leu Arg Glu Glu Val Ser Val Ala 
1               5                   10                  15


Ala Val Val Arg Trp Ile Ala Arg Ser Thr Gln Gly Ser Glu Asp Asn 
            20                  25                  30


Ala Gly Glu Ala Ala Ala Leu Ser Ser Leu Arg Ala Leu Arg Lys Glu 
        35                  40                  45


Phe Val Pro Phe Leu Leu Asn Phe Leu Arg Glu Gln Ser Ser Arg Val 
    50                  55                  60


Leu Pro Gln Gly Pro Pro Thr Pro Ala Lys Thr Pro Gly Ala Ser Ala 
65                  70                  75                  80


Ala Leu Pro Gly Arg Pro Gly Gly Pro Pro Arg Gly Ser Arg Gly Ala 
                85                  90                  95


Arg Ser Gln Leu Phe Pro Pro Thr Glu Ala Gln Ser Thr Ala Ala Glu 
            100                 105                 110


Ala Pro Leu Ala Arg Arg Gly Gly Arg Arg Arg Gly Pro Gly Pro Ala 
        115                 120                 125


Arg Glu Arg Gly Gly Arg Gly Leu Glu Glu Gly Val Ser Gly Glu Ser 
    130                 135                 140


Leu Pro Gly Ala Gly Gly Arg Arg Leu Arg Gly Ser Gly Ser Pro Ser 
145                 150                 155                 160


Arg Pro Ser Leu Thr Leu Ser Asp Pro Pro Asn Leu Ser Asn Leu Glu 
                165                 170                 175


Glu Phe Pro Pro Val Gly Ser Val Pro Pro Gly Pro Thr Gly Thr Lys 
            180                 185                 190


Pro Ser Arg Arg Ile Asn Pro Thr Pro Val Ser Glu Glu Arg Ser Leu 
        195                 200                 205


Ser Lys Pro Lys Thr Cys Phe Thr Ser Pro Pro Ile Ser Cys Val Pro 
    210                 215                 220


Ser Ser Gln Pro Ser Ala Leu Asp Thr Ser Pro Trp Gly Leu Gly Leu 
225                 230                 235                 240


Pro Pro Gly Cys Arg Ser Leu Gln Glu Glu Arg Glu Met Leu Arg Lys 
                245                 250                 255


Glu Arg Ser Lys Gln Leu Gln Gln Ser Pro Thr Pro Thr Cys Pro Thr 
            260                 265                 270


Pro Glu Leu Gly Ser Pro Leu Pro Ser Arg Thr Gly Ser Leu Thr Asp 
        275                 280                 285


Glu Pro Ala Asp Pro Ala Arg Val Ser Ser Arg Gln Arg Leu Glu Leu 
    290                 295                 300


Val Ala Leu Val Tyr Ser Ser Cys Ile Ala Glu Asn Leu Val Pro Asn 
305                 310                 315                 320


Leu Phe Leu Glu Leu Phe Phe Val Phe Gln Leu Leu Thr Ala Arg Arg 
                325                 330                 335


Met Val Thr Ala Lys Asp Ser Asp Pro Glu Leu Ser Pro Ala Val Leu 
            340                 345                 350


Asp Ser Leu Glu Ser Pro Leu Phe Gln Ser Ile His Asp Cys Val Phe 
        355                 360                 365


Phe Ala Val Gln Val Leu Glu Cys His Phe Gln Val Leu Ser Asn Leu 
    370                 375                 380


Asp Lys Gly Thr Leu Lys Leu Leu Ala Glu Asn Glu Arg Leu Leu Cys 
385                 390                 395                 400


Phe Ser Pro Ala Leu Gln Gly Arg Leu Arg Ala Ala Tyr Glu Gly Ser 
                405                 410                 415


Val Ala Lys Val Ser Leu Val Met Pro Pro Ser Thr Gln Ala Val Ser 
            420                 425                 430


Phe Gln Pro Glu Thr Asp Asn Arg Ala Asn Phe Ser Ser Asp Arg Ala 
        435                 440                 445


Phe His Thr Phe Lys Lys Gln Arg Asp Val Phe Tyr Glu Val Leu Arg 
    450                 455                 460


Glu Trp Glu Asp His His Glu Glu Pro Gly Trp Asp Phe Glu Lys Gly 
465                 470                 475                 480


Leu Gly Ser Arg Ile Arg Ala Met Met Gly Gln Leu Ser Ala Ala Cys 
                485                 490                 495


Ser His Ser His Phe Val Arg Leu Phe Gln Lys Gln Leu Leu Gln Met 
            500                 505                 510


Cys Gln Ser Pro Gly Gly Ala Gly Gly Thr Val Leu Gly Glu Ala Pro 
        515                 520                 525


Asp Val Leu Ser Met Leu Gly Ala Asp Lys Leu Gly Arg Leu Trp Arg 
    530                 535                 540


Leu Gln Glu Arg Leu Met Ala Pro Gln Ser Ser Gly Gly Pro Cys Pro 
545                 550                 555                 560


Pro Pro Thr Phe Pro Gly Cys Gln Gly Phe Phe Arg Asp Phe Ile Leu 
                565                 570                 575


Ser Ala Ser Ser Phe Gln Phe Asn Gln His Leu Met Asp Ser Leu Ser 
            580                 585                 590


Leu Lys Ile Gln Glu Leu Asn Gly Leu Ala Leu Pro Gln His Glu Pro 
        595                 600                 605


Asn Asp Glu Asp Gly Glu Ser Asp Val Asp Trp Gln Gly Glu Arg Lys 
    610                 615                 620


Gln Phe Ala Val Val Leu Leu Ser Leu Arg Leu Leu Ala Lys Phe Leu 
625                 630                 635                 640


Gly Phe Val Ala Phe Leu Pro Tyr Arg Gly Pro Glu Pro Pro Pro Thr 
                645                 650                 655


Gly Glu Leu Gln Asp Ser Ile Leu Ala Leu Arg Ser Gln Val Pro Pro 
            660                 665                 670


Val Leu Asp Val Arg Thr Leu Leu Gln Arg Gly Leu Gln Ala Arg Arg 
        675                 680                 685


Ala Val Leu Thr Val Pro Trp Leu Val Glu Phe Leu Ser Phe Ala Asp 
    690                 695                 700


His Val Val Pro Leu Leu Glu Tyr Tyr Arg Asp Ile Phe Thr Leu Leu 
705                 710                 715                 720


Leu Arg Leu His Arg Ser Leu Val Leu Ser Gln Glu Ser Glu Gly Lys 
                725                 730                 735


Met Cys Phe Leu Asn Lys Leu Leu Leu Leu Ala Val Leu Gly Trp Leu 
            740                 745                 750


Phe Gln Ile Pro Thr Val Pro Glu Asp Leu Phe Phe Leu Glu Glu Gly 
        755                 760                 765


Pro Ser Tyr Ala Phe Glu Val Asp Thr Val Ala Pro Glu His Gly Leu 
    770                 775                 780


Asp Asn Ala Pro Val Val Asp Gln Gln Leu Leu Tyr Thr Cys Cys Pro 
785                 790                 795                 800


Tyr Ile Gly Glu Leu Arg Lys Leu Leu Ala Ser Trp Val Ser Gly Ser 
                805                 810                 815


Ser Gly Arg Ser Gly Gly Phe Met Arg Lys Ile Thr Pro Thr Thr Thr 
            820                 825                 830


Thr Ser Leu Gly Ala Gln Pro Ser Gln Thr Ser Gln Gly Leu Gln Ala 
        835                 840                 845


Gln Leu Ala Gln Ala Phe Phe His Asn Gln Pro Pro Ser Leu Arg Arg 
    850                 855                 860


Thr Val Glu Phe Val Ala Glu Arg Ile Gly Ser Asn Cys Val Lys His 
865                 870                 875                 880


Ile Lys Ala Thr Leu Val Ala Asp Leu Val Arg Gln Ala Glu Ser Leu 
                885                 890                 895


Leu Gln Glu Gln Leu Val Thr Gln Gly Glu Glu Gly Gly Asp Pro Ala 
            900                 905                 910


Gln Leu Leu Glu Ile Leu Cys Ser Gln Leu Cys Pro His Gly Ala Gln 
        915                 920                 925


Ala Leu Ala Leu Gly Arg Glu Phe Cys Gln Arg Lys Ser Pro Gly Ala 
    930                 935                 940


Val Arg Ala Leu Leu Pro Glu Glu Thr Pro Ala Ala Val Leu Ser Ser 
945                 950                 955                 960


Ala Glu Asn Ile Ala Val Gly Leu Ala Thr Glu Lys Ala Cys Ala Trp 
                965                 970                 975


Leu Ser Ala Asn Ile Thr Ala Leu Ile Arg Arg Glu Val Lys Ala Ala 
            980                 985                 990


Val Ser Arg Thr Leu Arg Ala Gln Gly Pro Glu Pro Ala Ala Arg Gly 
        995                 1000                1005


Glu Arg Arg Gly Cys Ser Arg Ala Cys Glu His His Ala Pro Leu Pro 
    1010                1015                1020


Ser His Leu Ile Ser Glu Ile Lys Asp Val Leu Ser Leu Ala Val Gly 
1025                1030                1035                1040


Pro Arg Asp Pro Asp Glu Gly Val Ser Pro Glu His Leu Glu Gln Leu 
                1045                1050                1055


Leu Gly Gln Leu Gly Gln Thr Leu Arg Cys Arg Gln Phe Leu Cys Pro 
            1060                1065                1070


Pro Ala Glu Gln His Leu Ala Lys Cys Ser Val Glu Leu Ala Ser Leu 
        1075                1080                1085


Leu Val Ala Asp Gln Ile Pro Ile Leu Gly Pro Pro Ala Gln Tyr Arg 
    1090                1095                1100


Leu Glu Arg Gly Gln Ala Arg Arg Leu Leu His Met Leu Leu Ser Leu 
1105                1110                1115                1120


Trp Lys Glu Asp Phe Gln Gly Pro Val Pro Leu Gln Leu Leu Leu Ser 
                1125                1130                1135


Pro Arg Asn Val Gly Leu Leu Ala Asp Thr Arg Pro Arg Glu Trp Asp 
            1140                1145                1150


Leu Leu Leu Phe Leu Leu Arg Glu Leu Val Glu Lys Gly Leu Met Gly 
        1155                1160                1165


Arg Met Glu Ile Glu Ala Cys Leu Gly Ser Leu His Gln Ala Gln Trp 
    1170                1175                1180


Pro Gly Asp Phe Ala Glu Glu Leu Ala Thr Leu Ser Asn Leu Phe Leu 
1185                1190                1195                1200


Ala Glu Pro His Leu Pro Glu Pro Gln Leu Arg Ala Cys Glu Leu Val 
                1205                1210                1215


Gln Pro Asn Arg Gly Thr Val Leu Ala Gln Ser 
            1220                1225


<210>  1035
<211>  5635
<212>  DNA
<213>  Homo sapiens

<400>  1035
agaataacgt cgggtcgggt cagcgggctc tgcagtagtc gccgcagcgg cgatgggagc     60

ggtggggacg aggcggcggc ggcggcagga gggggagcag gtgctggcac aagagcagcg    120

gcttggggga gccggcagca gcagtaacag cagcagcagc cgccgccgcc gccgccagta    180

aacgcggacg gtaccccagg ggactaccca gccggccggc cctggaagcc gcgctcgggt    240

cccgccgcag tcggcggtgg gggatgggca ggcagtggcg gtcccgcctg ccgagggtta    300

acccccgccg gtcccggtcc tgagctggac cagagccctc ctccagaaac ccctgcgtcc    360

gccacggccc aggttaaatg gaaaccaccc ttgggaactg gatgcctgtg tagctgttct    420

accatatcag tgtattgcaa tgagtggggg aggagagcag ctggatatcc tgagtgttgg    480

aatcctagtg aaagaaagat ggaaagtgtt gagaaagatt gggggtgggg gctttggaga    540

aatttacgat gccttggaca tgctcaccag ggaaaatgtt gcactgaagg tggaatcagc    600

tcaacaacca aaacaagttc tgaaaatgga agttgctgtt ttgaaaaagc tgcaagggaa    660

agaccatgtt tgtagattta ttggctgtgg gaggaatgat cgattcaact atgtggtcat    720

gcagttgcag ggtcggaatc tggcagatct tcgccgtagc cagtcccgag gcacattcac    780

cattagtacc actctccggc tgggtagaca gattttggag tctattgaaa gcattcattc    840

tgtgggattc ttgcatcgag acatcaaacc gtcgaacttc gctatgggtc gctttcctag    900

tacatgtagg aaatgttaca tgcttgattt tggcttggct cgacaattta ccaattcctg    960

tggtgacgtc agaccacctc gagctgtggc aggttttcga gggacagttc gttatgcatc   1020

aatcaacgca catcggaaca gggaaatggg aagacatgat gacctttggt ccttattcta   1080

catgttggtg gagtttgtgg ttggtcagct gccctggaga aaaataaagg acaaggagca   1140

agtaggctct attaaggaga gatatgacca caggctcatg ttgaaacatc tccctccaga   1200

attcagcatc tttctagacc atatctcttc tttggattat tttacaaaac cagactacca   1260

gcttcttaca tccgtgtttg acaatagcat caagactttt ggagtaattg agagtgaccc   1320

ttttgactgg gagaagactg gaaatgatgg ctccctaaca accaccacta cttctaccac   1380

ccctcagttg cacactcgct tgacccctgc tgcaattgga attgccaatg ctactcccat   1440

ccctggagac ttgcttcgag aaaatacaga tgaggtattt ccagatgaac agcttagcga   1500

tggagaaaat ggcatccctg ttggtgtgtc accagataaa ttgcctggat ctctgggaca   1560

cccccgtccc caggagaagg atgtttggga agagatggat gccaacaaaa acaagataaa   1620

gcttggaatt tgtaaggctg ctactgaaga ggagaacagc catggccagg caaatggtct   1680

tctcaatgct ccaagccttg ggtcaccaat tcgtgtccgc tcagagatta ctcagccaga   1740

cagagatatt ccactggtgc gaaagttacg ttccattcac agctttgagc tggaaaaacg   1800

tctgaccctg gagccaaagc cagacactga caagttcctt gagacctgcc tggagaaaat   1860

gcagaaagat accagtgcag gaaaagaatc tattctccct gctctgctgc ataagccttg   1920

cgttcctgct gtgtcccgta ctgaccacat ctggcactat gatgaagaat atcttccaga   1980

tgcctccaag cctgcttctg ccaacacccc tgagcaggca gatggtggtg gcagcaatgg   2040

atttatagct gttaacctga gctcttgcaa gcaagaaatt gattccaaag aatgggtgat   2100

tgtggacaag gagcaggacc ttcaggattt taggacaaat gaggctgtag gacataaaac   2160

aactggaagt ccttctgatg aggagcctga agtacttcaa gtcctggagg catcacctca   2220

agatgaaaag ctccagttag gtccttgggc agaaaatgat catttaaaga aggaaacctc   2280

aggtgtggtc ttagcacttt ctgcagaggg tcctcctact gctgcttcag aacaatatac   2340

agataggctg gaactccagc ctggagctgc tagtcagttt attgcagcga cgcccacaag   2400

tctaatggag gcgcaggcag aaggacccct tacagcgatt acaattccta gaccttctgt   2460

ggcatctaca cagtcaactt caggaagctt tcactgtggt cagcagccag agaagaaaga   2520

tcttcagccc atggagccca ctgtggaact ttactctcca agggaaaact tctctggctt   2580

ggttgtgaca gagggtgaac ctcctagtgg aggaagcaga acagatttgg ggcttcagat   2640

agatcacatt ggtcatgaca tgttacccaa cattagagaa agtaacaaat ctcaagacct   2700

gggaccaaaa gaacttcctg atcataatag actggttgtg agagaatttg aaaatctccc   2760

tggggaaact gaagagaaaa gcatcctttt agagtcagat aatgaagatg agaagttaag   2820

tagagggcag cattgtattg agatctcctc tctcccagga gatttggtaa ttgtggaaaa   2880

ggatcactca gctactactg aacctcttga tgtgacaaaa acacagactt ttagtgtggt   2940

gccaaatcaa gacaaaaata atgagataat gaagcttctg acagttggaa cttcagaaat   3000

ttcttccaga gacattgacc cacatgttga aggtcagata ggccaagtgg cagaaatgca   3060

aaaaaataag atatctaagg atgatgacat catgagtgaa gacttgccag gtcatcaagg   3120

agacctctct acttttttgc accaagaggg caagagagag aaaatcaccc ctagaaatgg   3180

agaactattt cattgtgttt cagagaatga acatggtgcc ccaacccgga aggatatggt   3240

taggtcatcc tttgtaacta gacacagccg aatccctgtt ttagcacaag agatagactc   3300

aactttggaa tcatcctctc cagtttctgc aaaagaaaag ctcctccaaa agaaagccta   3360

tcagccagac ctagtcaagc ttctggtgga aaaaagacaa ttcaagtcct tccttggcga   3420

cctctcaagt gcctctgata aattgctaga ggagaaacta gctactgttc ctgctccctt   3480

ttgtgaggag gaagtgctca ctcccttttc aagactgaca gtagattctc acctgagtag   3540

gtcagctgaa gatagctttc tgtcacccat catctcccag tctagaaaga gcaaaattcc   3600

aaggccagtt tcatgggtca acacagatca ggtcaatagc tcaacttcgt ctcagttctt   3660

tcctcggcca ccaccaggaa agccacccac gaggcctgga gtagaagcca ggctacgcag   3720

atataaagtc ctagggagta gtaactccga ctcagacctt ttctcccgcc tggcccaaat   3780

tcttcaaaat ggatctcaga aaccccggag cactactcag tgcaagagtc caggatctcc   3840

tcacaatcca aaaacaccac ccaagagtcc agttgtccct cgcaggagtc ccagtgcctc   3900

tcctcgaagc tcatccttgc ctcgcacgtc tagttcctca ccatctaggg ctggacggcc   3960

ccaccatgac cagaggagtt cgtccccaca tctggggaga agcaagtcac ctcccagcca   4020

ctcaggatct tcctcctcca ggaggtcctg ccaacaggag cattgcaaac ccagcaagaa   4080

tggcctgaaa ggatccggca gcctccacca ccactcagcc agcactaaaa ccccccaagg   4140

gaagagtaag ccagccagta aactcagcag ataggagcca ggctgcatct ctttgaaagg   4200

tgtgagatct tcctcctaaa cctgatgcat gtgtgtccct gtactttcta tgtaaaaaaa   4260

tcagtgttga tcttctcttg caaaagaaag taacatgatc aattatttat aagaagacat   4320

aatacatgat aaggaattac ctaaggcagg cagcaagtag attaggaatc aatgtctttg   4380

tacaagaagg aaaaatagag caaaaatcca agggggagaa actcattaaa atgagctctc   4440

attttttaag ctgcctttga aacaaaagag ttgaggatag gagatagaat ggaattttag   4500

gggggttgcc taattttttt aagcctcaat tcaaagatta tatagcaaaa gtgaaacttc   4560

ttgtttgata ttttcattca aaactttccc accctgaaga gtcattgatc agatattaga   4620

ttatataaga agtctgttgc cagggagcca gtattcatgt atatttggct tgtgtgttta   4680

tttcgtgtat tgagaatgaa cacctttact ttgcctcatt cctagtaccc tccctggagt   4740

tcagattttt ttttaaaatt ttgtatgtct cgtctgattc aatctctctg cttttatttt   4800

atggtcctag ttgtactatc aaatccaatt actttttttt aggtccccct gatttttttt   4860

ttttagagca agagttctta acatattaca tttttattat gaaaaataag aaagttaggt   4920

aaaggaaaga aaagtctaac tagagctatt ttgcaggctt tagtgtttag ggagagaaag   4980

aaagtgtggg ttaatagcct tcaagataga agatgccctt tcatctctgt taagtgtcct   5040

cctttagaaa cttgagtaga aggaaaactg accagagtag actgcttcct taagtcttct   5100

gggttccaac tgtttgtaat atcagcatcc aagatgatac gagggaagca caatgctttg   5160

gactgtgatt tgagatttag aaataaatta gatatattat tgaggcttag aatcctcaaa   5220

ctttgtattt tatacattta gccaataagg aattaatatc tggggaaata aatttaggca   5280

aatatttctt ttttaatgtt ttattacctg cttctcctgt gttttagttc aacatttggg   5340

cttcttggcc tgattttcat acaatctcaa tttacgaagc tgtaaagagg aagatatttg   5400

ttctaatctc actcttctaa taggaatcag gcaaatgaaa gtctaccaga cttttaaaat   5460

gggctgtttt tatactctct aggtgttttg tgttgtaaag accttattaa ggtcaggtaa   5520

attggtctgc ttgctgttga aatttgcctt ctagcaaaca tatgtgcttt ctgtttgacc   5580

ttgtgtttgc tgccaaacct aatacagttg aattgggaaa caaaaaaaaa aaaaa        5635


<210>  1036
<211>  1244
<212>  PRT
<213>  Homo sapiens

<400>  1036

Met Ser Gly Gly Gly Glu Gln Leu Asp Ile Leu Ser Val Gly Ile Leu 
1               5                   10                  15


Val Lys Glu Arg Trp Lys Val Leu Arg Lys Ile Gly Gly Gly Gly Phe 
            20                  25                  30


Gly Glu Ile Tyr Asp Ala Leu Asp Met Leu Thr Arg Glu Asn Val Ala 
        35                  40                  45


Leu Lys Val Glu Ser Ala Gln Gln Pro Lys Gln Val Leu Lys Met Glu 
    50                  55                  60


Val Ala Val Leu Lys Lys Leu Gln Gly Lys Asp His Val Cys Arg Phe 
65                  70                  75                  80


Ile Gly Cys Gly Arg Asn Asp Arg Phe Asn Tyr Val Val Met Gln Leu 
                85                  90                  95


Gln Gly Arg Asn Leu Ala Asp Leu Arg Arg Ser Gln Ser Arg Gly Thr 
            100                 105                 110


Phe Thr Ile Ser Thr Thr Leu Arg Leu Gly Arg Gln Ile Leu Glu Ser 
        115                 120                 125


Ile Glu Ser Ile His Ser Val Gly Phe Leu His Arg Asp Ile Lys Pro 
    130                 135                 140


Ser Asn Phe Ala Met Gly Arg Phe Pro Ser Thr Cys Arg Lys Cys Tyr 
145                 150                 155                 160


Met Leu Asp Phe Gly Leu Ala Arg Gln Phe Thr Asn Ser Cys Gly Asp 
                165                 170                 175


Val Arg Pro Pro Arg Ala Val Ala Gly Phe Arg Gly Thr Val Arg Tyr 
            180                 185                 190


Ala Ser Ile Asn Ala His Arg Asn Arg Glu Met Gly Arg His Asp Asp 
        195                 200                 205


Leu Trp Ser Leu Phe Tyr Met Leu Val Glu Phe Val Val Gly Gln Leu 
    210                 215                 220


Pro Trp Arg Lys Ile Lys Asp Lys Glu Gln Val Gly Ser Ile Lys Glu 
225                 230                 235                 240


Arg Tyr Asp His Arg Leu Met Leu Lys His Leu Pro Pro Glu Phe Ser 
                245                 250                 255


Ile Phe Leu Asp His Ile Ser Ser Leu Asp Tyr Phe Thr Lys Pro Asp 
            260                 265                 270


Tyr Gln Leu Leu Thr Ser Val Phe Asp Asn Ser Ile Lys Thr Phe Gly 
        275                 280                 285


Val Ile Glu Ser Asp Pro Phe Asp Trp Glu Lys Thr Gly Asn Asp Gly 
    290                 295                 300


Ser Leu Thr Thr Thr Thr Thr Ser Thr Thr Pro Gln Leu His Thr Arg 
305                 310                 315                 320


Leu Thr Pro Ala Ala Ile Gly Ile Ala Asn Ala Thr Pro Ile Pro Gly 
                325                 330                 335


Asp Leu Leu Arg Glu Asn Thr Asp Glu Val Phe Pro Asp Glu Gln Leu 
            340                 345                 350


Ser Asp Gly Glu Asn Gly Ile Pro Val Gly Val Ser Pro Asp Lys Leu 
        355                 360                 365


Pro Gly Ser Leu Gly His Pro Arg Pro Gln Glu Lys Asp Val Trp Glu 
    370                 375                 380


Glu Met Asp Ala Asn Lys Asn Lys Ile Lys Leu Gly Ile Cys Lys Ala 
385                 390                 395                 400


Ala Thr Glu Glu Glu Asn Ser His Gly Gln Ala Asn Gly Leu Leu Asn 
                405                 410                 415


Ala Pro Ser Leu Gly Ser Pro Ile Arg Val Arg Ser Glu Ile Thr Gln 
            420                 425                 430


Pro Asp Arg Asp Ile Pro Leu Val Arg Lys Leu Arg Ser Ile His Ser 
        435                 440                 445


Phe Glu Leu Glu Lys Arg Leu Thr Leu Glu Pro Lys Pro Asp Thr Asp 
    450                 455                 460


Lys Phe Leu Glu Thr Cys Leu Glu Lys Met Gln Lys Asp Thr Ser Ala 
465                 470                 475                 480


Gly Lys Glu Ser Ile Leu Pro Ala Leu Leu His Lys Pro Cys Val Pro 
                485                 490                 495


Ala Val Ser Arg Thr Asp His Ile Trp His Tyr Asp Glu Glu Tyr Leu 
            500                 505                 510


Pro Asp Ala Ser Lys Pro Ala Ser Ala Asn Thr Pro Glu Gln Ala Asp 
        515                 520                 525


Gly Gly Gly Ser Asn Gly Phe Ile Ala Val Asn Leu Ser Ser Cys Lys 
    530                 535                 540


Gln Glu Ile Asp Ser Lys Glu Trp Val Ile Val Asp Lys Glu Gln Asp 
545                 550                 555                 560


Leu Gln Asp Phe Arg Thr Asn Glu Ala Val Gly His Lys Thr Thr Gly 
                565                 570                 575


Ser Pro Ser Asp Glu Glu Pro Glu Val Leu Gln Val Leu Glu Ala Ser 
            580                 585                 590


Pro Gln Asp Glu Lys Leu Gln Leu Gly Pro Trp Ala Glu Asn Asp His 
        595                 600                 605


Leu Lys Lys Glu Thr Ser Gly Val Val Leu Ala Leu Ser Ala Glu Gly 
    610                 615                 620


Pro Pro Thr Ala Ala Ser Glu Gln Tyr Thr Asp Arg Leu Glu Leu Gln 
625                 630                 635                 640


Pro Gly Ala Ala Ser Gln Phe Ile Ala Ala Thr Pro Thr Ser Leu Met 
                645                 650                 655


Glu Ala Gln Ala Glu Gly Pro Leu Thr Ala Ile Thr Ile Pro Arg Pro 
            660                 665                 670


Ser Val Ala Ser Thr Gln Ser Thr Ser Gly Ser Phe His Cys Gly Gln 
        675                 680                 685


Gln Pro Glu Lys Lys Asp Leu Gln Pro Met Glu Pro Thr Val Glu Leu 
    690                 695                 700


Tyr Ser Pro Arg Glu Asn Phe Ser Gly Leu Val Val Thr Glu Gly Glu 
705                 710                 715                 720


Pro Pro Ser Gly Gly Ser Arg Thr Asp Leu Gly Leu Gln Ile Asp His 
                725                 730                 735


Ile Gly His Asp Met Leu Pro Asn Ile Arg Glu Ser Asn Lys Ser Gln 
            740                 745                 750


Asp Leu Gly Pro Lys Glu Leu Pro Asp His Asn Arg Leu Val Val Arg 
        755                 760                 765


Glu Phe Glu Asn Leu Pro Gly Glu Thr Glu Glu Lys Ser Ile Leu Leu 
    770                 775                 780


Glu Ser Asp Asn Glu Asp Glu Lys Leu Ser Arg Gly Gln His Cys Ile 
785                 790                 795                 800


Glu Ile Ser Ser Leu Pro Gly Asp Leu Val Ile Val Glu Lys Asp His 
                805                 810                 815


Ser Ala Thr Thr Glu Pro Leu Asp Val Thr Lys Thr Gln Thr Phe Ser 
            820                 825                 830


Val Val Pro Asn Gln Asp Lys Asn Asn Glu Ile Met Lys Leu Leu Thr 
        835                 840                 845


Val Gly Thr Ser Glu Ile Ser Ser Arg Asp Ile Asp Pro His Val Glu 
    850                 855                 860


Gly Gln Ile Gly Gln Val Ala Glu Met Gln Lys Asn Lys Ile Ser Lys 
865                 870                 875                 880


Asp Asp Asp Ile Met Ser Glu Asp Leu Pro Gly His Gln Gly Asp Leu 
                885                 890                 895


Ser Thr Phe Leu His Gln Glu Gly Lys Arg Glu Lys Ile Thr Pro Arg 
            900                 905                 910


Asn Gly Glu Leu Phe His Cys Val Ser Glu Asn Glu His Gly Ala Pro 
        915                 920                 925


Thr Arg Lys Asp Met Val Arg Ser Ser Phe Val Thr Arg His Ser Arg 
    930                 935                 940


Ile Pro Val Leu Ala Gln Glu Ile Asp Ser Thr Leu Glu Ser Ser Ser 
945                 950                 955                 960


Pro Val Ser Ala Lys Glu Lys Leu Leu Gln Lys Lys Ala Tyr Gln Pro 
                965                 970                 975


Asp Leu Val Lys Leu Leu Val Glu Lys Arg Gln Phe Lys Ser Phe Leu 
            980                 985                 990


Gly Asp Leu Ser Ser Ala Ser Asp Lys Leu Leu Glu Glu Lys Leu Ala 
        995                 1000                1005


Thr Val Pro Ala Pro Phe Cys Glu Glu Glu Val Leu Thr Pro Phe Ser 
    1010                1015                1020


Arg Leu Thr Val Asp Ser His Leu Ser Arg Ser Ala Glu Asp Ser Phe 
1025                1030                1035                1040


Leu Ser Pro Ile Ile Ser Gln Ser Arg Lys Ser Lys Ile Pro Arg Pro 
                1045                1050                1055


Val Ser Trp Val Asn Thr Asp Gln Val Asn Ser Ser Thr Ser Ser Gln 
            1060                1065                1070


Phe Phe Pro Arg Pro Pro Pro Gly Lys Pro Pro Thr Arg Pro Gly Val 
        1075                1080                1085


Glu Ala Arg Leu Arg Arg Tyr Lys Val Leu Gly Ser Ser Asn Ser Asp 
    1090                1095                1100


Ser Asp Leu Phe Ser Arg Leu Ala Gln Ile Leu Gln Asn Gly Ser Gln 
1105                1110                1115                1120


Lys Pro Arg Ser Thr Thr Gln Cys Lys Ser Pro Gly Ser Pro His Asn 
                1125                1130                1135


Pro Lys Thr Pro Pro Lys Ser Pro Val Val Pro Arg Arg Ser Pro Ser 
            1140                1145                1150


Ala Ser Pro Arg Ser Ser Ser Leu Pro Arg Thr Ser Ser Ser Ser Pro 
        1155                1160                1165


Ser Arg Ala Gly Arg Pro His His Asp Gln Arg Ser Ser Ser Pro His 
    1170                1175                1180


Leu Gly Arg Ser Lys Ser Pro Pro Ser His Ser Gly Ser Ser Ser Ser 
1185                1190                1195                1200


Arg Arg Ser Cys Gln Gln Glu His Cys Lys Pro Ser Lys Asn Gly Leu 
                1205                1210                1215


Lys Gly Ser Gly Ser Leu His His His Ser Ala Ser Thr Lys Thr Pro 
            1220                1225                1230


Gln Gly Lys Ser Lys Pro Ala Ser Lys Leu Ser Arg 
        1235                1240


<210>  1037
<211>  11626
<212>  DNA
<213>  Homo sapiens

<400>  1037
gggagccgcg gcagagactg tgggtgccac aagcggacag gagccacagc tgggacagct     60

gcgagcggag ccgagcagtg gctgtagcgg ccacgactgg gagcagccgc cgccgcctcc    120

tcgggagtcg gagccgccgc ttctccactg gcaggggccg cctgaagtgg gagcagcgcc    180

tggagaaggc gggaggagcc cggcccgggg gacgggcggc gggatagcgg gaccccggcg    240

gcgcggtgcg cttcagggcg cagcggcggc cgcagaccga gccccgggcg cggcaagagg    300

cggcgggagc cggtggcggc tcggcatcat gcgtcgaggg cgtctgctgg agatcgccct    360

gggatttacc gtgcttttag cgtcctacac gagccatggg gcggacgcca atttggaggc    420

tgggaacgtg aaggaaacca gagccagtcg ggccaagaga agaggcggtg gaggacacga    480

cgcgcttaaa ggacccaatg tctgtggatc acgttataat gcttactgtt gccctggatg    540

gaaaacctta cctggcggaa atcagtgtat tgtccccatt tgccggcatt cctgtgggga    600

tggattttgt tcgaggccaa atatgtgcac ttgcccatct ggtcagatag ctccttcctg    660

tggctccaga tccatacaac actgcaatat tcgctgtatg aatggaggta gctgcagtga    720

cgatcactgt ctatgccaga aaggatacat agggactcac tgtggacaac ctgtttgtga    780

aagtggctgt ctcaatggag gaaggtgtgt ggccccaaat cgatgtgcat gcacttacgg    840

atttactgga ccccagtgtg aaagagatta caggacaggc ccatgtttta ctgtgatcag    900

caaccagatg tgccagggac aactcagcgg gattgtctgc acaaaaacgc tctgctgtgc    960

cacagtcggc cgagcctggg gccacccctg tgagatgtgt cctgcccagc ctcacccctg   1020

ccgccgtggc ttcattccaa atatccgcac gggagcttgt caagatgtgg atgaatgcca   1080

ggccatcccc gggctctgtc agggaggaaa ttgcattaat actgttgggt cttttgagtg   1140

caaatgccct gctggacaca aacttaatga agtgtcacaa aaatgtgaag atattgatga   1200

atgcagcacc attcctggaa tctgtgaagg gggtgaatgt acaaacacag tcagcagtta   1260

cttttgcaaa tgtccccctg gtttttacac ctctccagat ggtaccagat gcatagatgt   1320

tcgcccagga tactgttaca cagctctgac aaacgggcgc tgctctaacc agctgccaca   1380

gtccataacc aaaatgcagt gctgctgtga tgccggccga tgctggtctc caggggtcac   1440

tgtcgcccct gagatgtgtc ccatcagagc aaccgaggat ttcaacaagc tgtgctctgt   1500

tcctatggta attcctggga gaccagaata tcctccccca ccccttggcc ccattcctcc   1560

agttctccct gttcctcctg gctttcctcc tggacctcaa attccggtcc ctcgaccacc   1620

agtggaatat ctgtatccat ctcgggagcc accaagggtg ctgccagtaa acgttactga   1680

ttactgccag ttggtccgct atctctgtca aaatggacgc tgcattccaa ctcctgggag   1740

ttgccggtgt gagtgcaaca aagggttcca gctggacctc cgtggggagt gtattgatgt   1800

tgatgaatgt gagaaaaacc cctgtgctgg tggtgagtgt attaacaacc agggttcgta   1860

cacctgtcag tgccgagctg gatatcagag cacactcacg cggacagaat gccgagacat   1920

tgatgagtgt ttacagaatg gccggatctg caataatgga cgctgcatca acacagatgg   1980

cagttttcat tgcgtgtgta atgcgggctt tcatgttaca cgagatggga agaactgtga   2040

agatatggat gaatgcagca taaggaacat gtgccttaat ggaatgtgta tcaatgaaga   2100

tggcagtttt aaatgtattt gcaaacctgg attccagctg gcatcagatg gacgttattg   2160

caaagacatt aacgagtgtg aaacccctgg gatctgcatg aatgggcgtt gcgtcaacac   2220

tgatggctcc tacagatgtg aatgcttccc tggactggct gtgggtctgg atggccgtgt   2280

gtgtgttgac acacacatgc ggagcacatg ctatggtgga tacaagagag gccagtgtat   2340

caaacctttg tttggtgctg tcactaaatc tgaatgctgt tgcgccagca ctgagtatgc   2400

atttggggaa ccttgccagc cgtgtcctgc acagaattca gcggaatatc aggcactctg   2460

cagcagtggg ccaggaatga cgtcagcagg cagtgatata aatgaatgtg cactagatcc   2520

tgatatttgc ccaaatggaa tctgtgaaaa ccttcgtggg acctataaat gtatatgcaa   2580

ttcaggatat gaagtggatt caactgggaa aaactgcgtt gatattaatg aatgtgtact   2640

gaacagtctc ctttgtgaca atggacaatg tagaaatact cctggaagtt ttgtctgtac   2700

ctgccccaag ggatttatct acaaacctga tctaaaaaca tgtgaagaca ttgatgaatg   2760

cgaatcaagt ccttgcatta atggagtctg caagaacagc ccaggctctt ttatttgtga   2820

atgttcttct gaaagtactt tggatccaac aaaaaccatc tgcatagaaa ccatcaaggg   2880

cacttgctgg cagactgtca ttgatgggcg atgtgagatc aacatcaatg gagccacctt   2940

aaagtcccag tgctgctcct ccctcggtgc tgcgtgggga agcccgtgca ccctatgcca   3000

agttgatccc atatgtggta aagggtactc aagaattaaa ggaacacaat gtgaagatat   3060

agatgaatgt gaagtgttcc caggagtgtg taaaaatggc ctgtgtgtta acactagggg   3120

gtcattcaag tgtcagtgtc ccagtggaat gactttggat gccacaggaa ggatctgtct   3180

tgatatccgc ctggaaacct gcttcctgag gtacgaggac gaggagtgca ccctgcctat   3240

tgctggccgc caccgcatgg acgcctgctg ctgctccgtc ggggcagcct ggggtactga   3300

ggaatgcgag gagtgtccca tgagaaatac tcctgagtac gaggagctgt gtccgagagg   3360

acccggattt gccacaaaag aaattacaaa tggaaagcct ttcttcaaag atatcaatga   3420

gtgcaagatg atacccagcc tctgcaccca cggcaagtgc agaaacacca ttggcagctt   3480

taagtgcagg tgtgacagcg gctttgctct tgattctgaa gaaaggaact gcacagacat   3540

tgacgaatgc cgcatatctc ctgacctctg tggcagaggc cagtgtgtga acacccctgg   3600

ggactttgaa tgcaagtgtg acgaaggcta tgaaagtgga ttcatgatga tgaagaactg   3660

catggatatt gatgagtgtc agagagatcc tctcctatgc cgaggtggtg tttgccataa   3720

cacagaggga agttaccgct gtgaatgccc gcctggccat cagctgtccc ccaacatctc   3780

cgcgtgtatc gacatcaatg aatgtgagct gagtgcacac ctgtgcccca atggccgttg   3840

cgtgaacctc atagggaagt atcagtgtgc ctgcaaccct ggctaccatt caactcccga   3900

taggctattt tgtgttgaca ttgatgaatg cagcataatg aatggtggtt gtgaaacctt   3960

ctgcacaaac tctgaaggca gctatgaatg tagctgtcag ccgggatttg cactaatgcc   4020

tgaccagaga tcatgcaccg acatcgatga gtgtgaagat aatcccaata tctgtgatgg   4080

tggtcagtgc acaaatatcc ctggagagta caggtgcttg tgttatgatg gattcatggc   4140

atctgaagac atgaagactt gtgtagatgt caatgagtgt gacctgaatc caaatatctg   4200

cctaagtggg acctgtgaaa acacgaaagg ctcatttatc tgccactgtg atatgggcta   4260

ctccggcaaa aaaggaaaaa ctggctgtac agacatcaat gaatgtgaaa ttggagcaca   4320

caactgtggc aaacatgctg tatgtaccaa tacagcagga agcttcaaat gtagctgcag   4380

tcccgggtgg attggagatg gcattaagtg cactgatctg gacgaatgtt ccaatggaac   4440

ccatatgtgc agccagcatg cagactgcaa gaataccatg ggatcttacc gctgtctgtg   4500

caaggaagga tacacaggtg atggcttcac ttgtacagac cttgatgagt gctctgagaa   4560

cctgaatctc tgtggcaatg gccagtgcct caatgcacca ggaggatacc gctgtgaatg   4620

cgacatgggc ttcgtgccca gtgctgacgg gaaagcctgt gaagatattg atgagtgctc   4680

ccttccgaac atctgtgtct ttggaacttg ccacaacctc cctggcctgt tccgctgtga   4740

gtgtgagata ggctacgaac tggacagaag cggcgggaac tgcacagatg tgaatgaatg   4800

cctggatcca accacgtgca tcagtgggaa ctgtgtcaac actccaggca gctatatctg   4860

tgactgccca cctgattttg aactgaaccc aactcgagtt ggctgtgttg atacccgctc   4920

tggaaattgc tatttggata ttcgacctcg aggagacaat ggagatacag cctgcagcaa   4980

tgaaattgga gttggtgttt ccaaagcttc ctgctgctgt tctctgggta aagcctgggg   5040

tactccttgt gagatgtgtc ctgctgtgaa cacatccgag tacaaaattc tttgtcctgg   5100

aggggaaggt ttccgaccaa atcctatcac cgttatattg gaagatattg atgagtgcca   5160

ggagctacca gggctgtgcc aaggaggaaa atgtatcaac acctttggga gtttccagtg   5220

ccgctgtcca accggctact acctgaatga agatacacga gtgtgtgatg atgtgaatga   5280

atgtgagact cctggaatct gtggtccagg gacatgttac aacaccgttg gcaactacac   5340

ctgtatctgt cctccagact acatgcaagt gaatggggga aataattgca tggatatgag   5400

aagaagtttg tgctacagaa actactatgc tgacaaccag acctgtgatg gagaattgtt   5460

attcaacatg accaagaaga tgtgctgctg ttcctacaac attggccggg cgtggaacaa   5520

gccctgtgaa cagtgtccca tcccaagtac agatgagttt gctacactct gtggaagtca   5580

aaggccaggc tttgtcatcg acatttatac cggtttaccc gttgatattg atgagtgccg   5640

ggagatccca ggggtctgtg aaaatggagt gtgtatcaac atggttggca gcttccgatg   5700

tgaatgtcca gtgggattct tctataatga caagttgttg gtttgtgaag atattgacga   5760

gtgtcagaac ggcccagtgt gccagcgcaa cgccgaatgc atcaacactg caggcagcta   5820

ccgctgtgac tgtaagcccg gctaccgctt cacctccaca ggacagtgca atgatcgtaa   5880

tgaatgtcaa gaaatcccca atatatgcag tcatgggcag tgcattgaca cagttggaag   5940

cttttattgc ctttgccaca ctggttttaa aacaaatgat gaccaaacca tgtgcttgga   6000

cataaatgaa tgtgaaagag atgcctgtgg gaatggaact tgccggaaca caattggttc   6060

cttcaactgc cgctgcaatc atggtttcat cctttctcac aacaatgact gtatagatgt   6120

tgatgaatgt gcaagtggaa atgggaatct ttgcagaaat ggccaatgca ttaatacagt   6180

ggggtctttc cagtgccagt gcaatgaagg ctatgaggtg gctccagatg ggaggacctg   6240

tgtggatatc aatgaatgtc ttctagaacc cagaaaatgt gcaccaggta cctgtcaaaa   6300

cttggatggg tcctacagat gcatttgccc acctggatac agtcttcaaa atgagaagtg   6360

tgaagatatt gatgagtgtg tcgaagagcc agaaatttgt gccctgggca catgcagtaa   6420

cactgaaggc agcttcaaat gtctgtgtcc agaagggttt tccttgtcct ccagtggaag   6480

aaggtgccaa gatttgcgaa tgagctactg ttatgcgaag tttgaaggag gaaagtgttc   6540

atcacccaaa tccagaaatc actccaagca ggaatgctgc tgtgccttga agggagaagg   6600

ctggggagac ccctgcgagc tctgccccac ggaacctgat gaggccttcc gccagatatg   6660

tccttatgga agtgggatca tcgtgggacc tgatgattca gcagttgata tggacgaatg   6720

caaagaaccc gatgtctgta aacatggaca gtgcatcaat acagatggtt cctatcgctg   6780

cgagtgtccc tttggttata ttctagcagg gaatgaatgt gtagatactg atgaatgttc   6840

tgttggcaat ccttgtggaa atggaacctg caagaatgtg attggaggtt ttgaatgcac   6900

ctgcgaggag ggatttgagc ccggtccaat gatgacatgt gaagatataa atgaatgtgc   6960

ccagaatcct ctgctctgtg ccttccgatg tgtgaacact tatgggtcat atgaatgcaa   7020

atgtcccgtg ggatatgtgc tcagagaaga ccgtaggatg tgcaaagatg aggatgagtg   7080

tgaagaggga aaacatgact gtactgaaaa acaaatggaa tgcaagaacc tcattggcac   7140

atatatgtgc atctgtggac ccgggtatca gcggagacct gatggagaag gctgtgtaga   7200

tgagaatgaa tgtcagacga agccagggat ctgtgagaat gggcgctgcc tcaacacccg   7260

tgggagctac acctgtgagt gtaatgatgg gtttaccgcc agccccaacc aggacgagtg   7320

ccttgacaat cgggaagggt actgcttcac agaggtgcta caaaacatgt gtcagatcgg   7380

ctccagcaac aggaaccccg tcaccaaatc ggaatgctgc tgtgacggag ggagaggctg   7440

gggtccccac tgtgagatct gccctttcca ggggactgtg gctttcaaga aactctgtcc   7500

ccatggccga ggattcatga ccaatggagc agatatcgat gaatgcaagg ttattcacga   7560

tgtttgccga aatggggaat gtgtcaatga cagaggatca tatcattgca tttgtaaaac   7620

tgggtacact ccagatataa ctgggacttc ctgtgtagat ctgaacgagt gcaaccaggc   7680

tcccaaaccc tgcaatttta tctgcaaaaa cacagaaggg agttaccagt gttcatgccc   7740

gaaaggctac attctgcaag aggatggaag gagctgcaaa gatcttgatg agtgtgcaac   7800

caagcaacac aactgccagt tcctatgtgt taacaccatt ggcggcttca catgcaaatg   7860

tcctcccgga tttacccaac accatacgtc ctgcattgat aacaatgaat gcacctctga   7920

catcaatctg tgcgggtcta agggcatttg ccagaacact cctggaagct tcacctgtga   7980

atgccagcgg ggattctcac ttgatcagac cggctccagc tgtgaagacg tggacgagtg   8040

tgagggtaac caccgctgcc agcatggctg ccagaacatc attgggggct acaggtgcag   8100

ctgcccccag ggctacctcc agcactacca gtggaaccag tgtgttgatg aaaacgaatg   8160

cctcagcgct cacatctgcg gaggagcctc ctgtcacaac accctgggga gctacaagtg   8220

catgtgtccc gccggcttcc agtatgaaca gttcagtgga ggatgccaag acatcaatga   8280

atgtggctct gcgcaggccc cctgcagcta tggctgttcc aataccgagg gcggttacct   8340

gtgtggctgt ccacctggtt acttccgcat aggccaaggg cactgtgttt ctggaatggg   8400

catgggccga ggaaacccag agccacctgt cagtggtgaa atggatgaca attcactctc   8460

cccagaggct tgttacgagt gtaagatcaa tggctacccc aaacggggca ggaaacggag   8520

aagcacaaac gaaactgatg cctccaatat cgaggatcag tctgagacag aagccaatgt   8580

gagtcttgca agttgggatg ttgagaagac agccatcttt gctttcaata tttcccacgt   8640

cagtaacaag gttcgaatcc tagaactcct tccagctctt acaactctga cgaatcacaa   8700

cagatacttg atcgaatctg gaaatgaaga tggcttcttt aaaatcaacc aaaaggaagg   8760

gatcagctac ctccacttca caaagaagaa gccagtggct ggaacctatt cattacaaat   8820

cagtagtact ccactttata aaaagaaaga acttaaccaa ctagaagaca aatatgacaa   8880

agactacctc agtggtgaac tgggtgataa tctgaagatg aaaatccagg ttttgcttca   8940

ttaattcacc atccagagac caaataatta aaagaaaaac aaatatagat aggtagaact   9000

atattttccc ccaatcagaa tcatcatatc ataggtacaa tctttcacca agtaaatttg   9060

tataaataag cactattctt tgtattacca aagcaaggta caggtgacta ccctagttca   9120

aaacaaccac tttctcaggc ttctcatgtg tgtagctaag ctaccttgtc atatgtgttg   9180

attcttgaaa actgggacgt gtatttccat tgggggttgg ccatttatgc tgacatgcca   9240

tccttccagc aaacgtacgg gaatgtgctt tcaattgatg gactactcta ttttttgcaa   9300

atttgtaaac tttgcttctc caaatacaag tactaggttg tccatttatg gtacctattt   9360

ggtgctagta aattttcaaa ctagatttat aaatgcactg taatatgtac acaacttaga   9420

aaccaaatta caagtattca gttccaatac ttcattaatt tcaatcaacc aaagttagtt   9480

cagtagctta tctcagttat gagtataata cattacatgt aaattaagtg tgtgtatact   9540

gtaatcgtgc tattttttat cattgaaaca tttataaact agaataataa tgcccttaat   9600

gtgagggttt gtaatggtgc ttattaagac caaagacttg ttaaatgtat acaccaagtg   9660

gtaatgaaat ttcggtgact ggcccacacg tgcatagagg tctgggagga ccaggaaaca   9720

gcctcagtgg ccagaggatc accagtgcat ccttcatcac agcatgtgca atatgccaag   9780

attaccctcg gtcattcctg tcaacaaggg gtcaatgtca taaatgtcac aataaaacaa   9840

tctcttcttt tttttagttt accccttggc tttgtgttct tgcatggatt tggggttgga   9900

ggggccattc cggaggctaa ataaagtctc ctggatttaa attatcctgg gtctcttact   9960

tatggcttat gaaagtacca aatgtataac cactagaaga aaatttaaca tatgagtcga  10020

tcccttgttt tatccattga aagtagcaga gtctggtgtc attaacctga cttgcttgtg  10080

agaaatttag attgtagagt catttctgaa acatgaccta attcatcttg tgacttttaa  10140

atagtcttaa ataccaagtt cagtcattgt cttagagcac atgaatttca ttataataga  10200

tttatcatgc ccccctctca aatatacaca gttttggcaa gccttaggtg ttctgttcca  10260

tttttttttc ccctaaacat ctttcgttag tcaatgctca tctaattaca aagggataat  10320

cccagactgt atccaattgc tgtaactttt ggtttcttaa tgtcataatt tttaaagtct  10380

gttttatttt aagtgcaata ttgagtattt agctgttagg ctcaatccgt cgatatgaaa  10440

taatttttta aatccctaag ggcaggaaag catttcgtgg tagtgaaaat aagaggaaat  10500

aagatggcat gaaggtggtg ggcggagaaa ctaggtagga cacaggaaag tgctctcaaa  10560

aatctttgaa gagctcagct gaaaaaaatg gagtagattt ggctcatact attccggaag  10620

gcaaaaccag ggtcagctga tgtcagcccc agtttaatac acacggtccc aattatagag  10680

ctactcactg aaagaatggg tttccttgca ttgtggtgag ctccctgtca caagatagaa  10740

gagtttcagt ctaggcttaa tggcaaccat tggacaaaga tgctttcttc cacctaacag  10800

gccattaaca tcttaaaggt atttttgtat ctctaatttt gtttataata ggtgctcaac  10860

agaatgagct gaatggctgt tacaaagggg gtttgtacct tgggtaagag attaaaatat  10920

aactcaaaat ttccttctaa cgctgcacct atggaaccat gtgatagagg tgtattaaaa  10980

ttgttatcga agaatatata gcatatggta aacaacagtt tgcatatgga aaatgtcttt  11040

gataatttaa ccagaactgc attatattca ataacggatt ttctttataa caaacaacag  11100

gggaaaatgg agttggcaca cagtggatca ctttgatatt tttaatagtc caagtctgga  11160

ttttatttat tcctgagcca acaattttga acagcatatt ttccatgttt ctgactgtaa  11220

caaaacattt tcctcattgt tccattgtaa atattcctct tgttggaact ctttttaatc  11280

ctgagattta aacctgtacc tttcaattgt ctgtgacctt tcaatttcac tttcaatagt  11340

tgaagaactt ggctttgtaa atctctcaga agcttgaaaa tatcttgtct ctaccccctc  11400

agcccatttc atttgccaat aattattttg taagtagggt tgaaatgaac tcagctggcc  11460

ttgtgaaatg tttaaacttg cacaaacaac tacatttttg ttcaacaaat agcagtttac  11520

tcagccaaaa tcactttgga tattgccatt acaaatactg ttaaacttca gaaatcatgt  11580

ctgtaaatta gatgagccaa aataaaggac aattgggttg atgctg                 11626


<210>  1038
<211>  2871
<212>  PRT
<213>  Homo sapiens

<400>  1038

Met Arg Arg Gly Arg Leu Leu Glu Ile Ala Leu Gly Phe Thr Val Leu 
1               5                   10                  15


Leu Ala Ser Tyr Thr Ser His Gly Ala Asp Ala Asn Leu Glu Ala Gly 
            20                  25                  30


Asn Val Lys Glu Thr Arg Ala Ser Arg Ala Lys Arg Arg Gly Gly Gly 
        35                  40                  45


Gly His Asp Ala Leu Lys Gly Pro Asn Val Cys Gly Ser Arg Tyr Asn 
    50                  55                  60


Ala Tyr Cys Cys Pro Gly Trp Lys Thr Leu Pro Gly Gly Asn Gln Cys 
65                  70                  75                  80


Ile Val Pro Ile Cys Arg His Ser Cys Gly Asp Gly Phe Cys Ser Arg 
                85                  90                  95


Pro Asn Met Cys Thr Cys Pro Ser Gly Gln Ile Ala Pro Ser Cys Gly 
            100                 105                 110


Ser Arg Ser Ile Gln His Cys Asn Ile Arg Cys Met Asn Gly Gly Ser 
        115                 120                 125


Cys Ser Asp Asp His Cys Leu Cys Gln Lys Gly Tyr Ile Gly Thr His 
    130                 135                 140


Cys Gly Gln Pro Val Cys Glu Ser Gly Cys Leu Asn Gly Gly Arg Cys 
145                 150                 155                 160


Val Ala Pro Asn Arg Cys Ala Cys Thr Tyr Gly Phe Thr Gly Pro Gln 
                165                 170                 175


Cys Glu Arg Asp Tyr Arg Thr Gly Pro Cys Phe Thr Val Ile Ser Asn 
            180                 185                 190


Gln Met Cys Gln Gly Gln Leu Ser Gly Ile Val Cys Thr Lys Thr Leu 
        195                 200                 205


Cys Cys Ala Thr Val Gly Arg Ala Trp Gly His Pro Cys Glu Met Cys 
    210                 215                 220


Pro Ala Gln Pro His Pro Cys Arg Arg Gly Phe Ile Pro Asn Ile Arg 
225                 230                 235                 240


Thr Gly Ala Cys Gln Asp Val Asp Glu Cys Gln Ala Ile Pro Gly Leu 
                245                 250                 255


Cys Gln Gly Gly Asn Cys Ile Asn Thr Val Gly Ser Phe Glu Cys Lys 
            260                 265                 270


Cys Pro Ala Gly His Lys Leu Asn Glu Val Ser Gln Lys Cys Glu Asp 
        275                 280                 285


Ile Asp Glu Cys Ser Thr Ile Pro Gly Ile Cys Glu Gly Gly Glu Cys 
    290                 295                 300


Thr Asn Thr Val Ser Ser Tyr Phe Cys Lys Cys Pro Pro Gly Phe Tyr 
305                 310                 315                 320


Thr Ser Pro Asp Gly Thr Arg Cys Ile Asp Val Arg Pro Gly Tyr Cys 
                325                 330                 335


Tyr Thr Ala Leu Thr Asn Gly Arg Cys Ser Asn Gln Leu Pro Gln Ser 
            340                 345                 350


Ile Thr Lys Met Gln Cys Cys Cys Asp Ala Gly Arg Cys Trp Ser Pro 
        355                 360                 365


Gly Val Thr Val Ala Pro Glu Met Cys Pro Ile Arg Ala Thr Glu Asp 
    370                 375                 380


Phe Asn Lys Leu Cys Ser Val Pro Met Val Ile Pro Gly Arg Pro Glu 
385                 390                 395                 400


Tyr Pro Pro Pro Pro Leu Gly Pro Ile Pro Pro Val Leu Pro Val Pro 
                405                 410                 415


Pro Gly Phe Pro Pro Gly Pro Gln Ile Pro Val Pro Arg Pro Pro Val 
            420                 425                 430


Glu Tyr Leu Tyr Pro Ser Arg Glu Pro Pro Arg Val Leu Pro Val Asn 
        435                 440                 445


Val Thr Asp Tyr Cys Gln Leu Val Arg Tyr Leu Cys Gln Asn Gly Arg 
    450                 455                 460


Cys Ile Pro Thr Pro Gly Ser Cys Arg Cys Glu Cys Asn Lys Gly Phe 
465                 470                 475                 480


Gln Leu Asp Leu Arg Gly Glu Cys Ile Asp Val Asp Glu Cys Glu Lys 
                485                 490                 495


Asn Pro Cys Ala Gly Gly Glu Cys Ile Asn Asn Gln Gly Ser Tyr Thr 
            500                 505                 510


Cys Gln Cys Arg Ala Gly Tyr Gln Ser Thr Leu Thr Arg Thr Glu Cys 
        515                 520                 525


Arg Asp Ile Asp Glu Cys Leu Gln Asn Gly Arg Ile Cys Asn Asn Gly 
    530                 535                 540


Arg Cys Ile Asn Thr Asp Gly Ser Phe His Cys Val Cys Asn Ala Gly 
545                 550                 555                 560


Phe His Val Thr Arg Asp Gly Lys Asn Cys Glu Asp Met Asp Glu Cys 
                565                 570                 575


Ser Ile Arg Asn Met Cys Leu Asn Gly Met Cys Ile Asn Glu Asp Gly 
            580                 585                 590


Ser Phe Lys Cys Ile Cys Lys Pro Gly Phe Gln Leu Ala Ser Asp Gly 
        595                 600                 605


Arg Tyr Cys Lys Asp Ile Asn Glu Cys Glu Thr Pro Gly Ile Cys Met 
    610                 615                 620


Asn Gly Arg Cys Val Asn Thr Asp Gly Ser Tyr Arg Cys Glu Cys Phe 
625                 630                 635                 640


Pro Gly Leu Ala Val Gly Leu Asp Gly Arg Val Cys Val Asp Thr His 
                645                 650                 655


Met Arg Ser Thr Cys Tyr Gly Gly Tyr Lys Arg Gly Gln Cys Ile Lys 
            660                 665                 670


Pro Leu Phe Gly Ala Val Thr Lys Ser Glu Cys Cys Cys Ala Ser Thr 
        675                 680                 685


Glu Tyr Ala Phe Gly Glu Pro Cys Gln Pro Cys Pro Ala Gln Asn Ser 
    690                 695                 700


Ala Glu Tyr Gln Ala Leu Cys Ser Ser Gly Pro Gly Met Thr Ser Ala 
705                 710                 715                 720


Gly Ser Asp Ile Asn Glu Cys Ala Leu Asp Pro Asp Ile Cys Pro Asn 
                725                 730                 735


Gly Ile Cys Glu Asn Leu Arg Gly Thr Tyr Lys Cys Ile Cys Asn Ser 
            740                 745                 750


Gly Tyr Glu Val Asp Ser Thr Gly Lys Asn Cys Val Asp Ile Asn Glu 
        755                 760                 765


Cys Val Leu Asn Ser Leu Leu Cys Asp Asn Gly Gln Cys Arg Asn Thr 
    770                 775                 780


Pro Gly Ser Phe Val Cys Thr Cys Pro Lys Gly Phe Ile Tyr Lys Pro 
785                 790                 795                 800


Asp Leu Lys Thr Cys Glu Asp Ile Asp Glu Cys Glu Ser Ser Pro Cys 
                805                 810                 815


Ile Asn Gly Val Cys Lys Asn Ser Pro Gly Ser Phe Ile Cys Glu Cys 
            820                 825                 830


Ser Ser Glu Ser Thr Leu Asp Pro Thr Lys Thr Ile Cys Ile Glu Thr 
        835                 840                 845


Ile Lys Gly Thr Cys Trp Gln Thr Val Ile Asp Gly Arg Cys Glu Ile 
    850                 855                 860


Asn Ile Asn Gly Ala Thr Leu Lys Ser Gln Cys Cys Ser Ser Leu Gly 
865                 870                 875                 880


Ala Ala Trp Gly Ser Pro Cys Thr Leu Cys Gln Val Asp Pro Ile Cys 
                885                 890                 895


Gly Lys Gly Tyr Ser Arg Ile Lys Gly Thr Gln Cys Glu Asp Ile Asp 
            900                 905                 910


Glu Cys Glu Val Phe Pro Gly Val Cys Lys Asn Gly Leu Cys Val Asn 
        915                 920                 925


Thr Arg Gly Ser Phe Lys Cys Gln Cys Pro Ser Gly Met Thr Leu Asp 
    930                 935                 940


Ala Thr Gly Arg Ile Cys Leu Asp Ile Arg Leu Glu Thr Cys Phe Leu 
945                 950                 955                 960


Arg Tyr Glu Asp Glu Glu Cys Thr Leu Pro Ile Ala Gly Arg His Arg 
                965                 970                 975


Met Asp Ala Cys Cys Cys Ser Val Gly Ala Ala Trp Gly Thr Glu Glu 
            980                 985                 990


Cys Glu Glu Cys Pro Met Arg Asn Thr Pro Glu Tyr Glu Glu Leu Cys 
        995                 1000                1005


Pro Arg Gly Pro Gly Phe Ala Thr Lys Glu Ile Thr Asn Gly Lys Pro 
    1010                1015                1020


Phe Phe Lys Asp Ile Asn Glu Cys Lys Met Ile Pro Ser Leu Cys Thr 
1025                1030                1035                1040


His Gly Lys Cys Arg Asn Thr Ile Gly Ser Phe Lys Cys Arg Cys Asp 
                1045                1050                1055


Ser Gly Phe Ala Leu Asp Ser Glu Glu Arg Asn Cys Thr Asp Ile Asp 
            1060                1065                1070


Glu Cys Arg Ile Ser Pro Asp Leu Cys Gly Arg Gly Gln Cys Val Asn 
        1075                1080                1085


Thr Pro Gly Asp Phe Glu Cys Lys Cys Asp Glu Gly Tyr Glu Ser Gly 
    1090                1095                1100


Phe Met Met Met Lys Asn Cys Met Asp Ile Asp Glu Cys Gln Arg Asp 
1105                1110                1115                1120


Pro Leu Leu Cys Arg Gly Gly Val Cys His Asn Thr Glu Gly Ser Tyr 
                1125                1130                1135


Arg Cys Glu Cys Pro Pro Gly His Gln Leu Ser Pro Asn Ile Ser Ala 
            1140                1145                1150


Cys Ile Asp Ile Asn Glu Cys Glu Leu Ser Ala His Leu Cys Pro Asn 
        1155                1160                1165


Gly Arg Cys Val Asn Leu Ile Gly Lys Tyr Gln Cys Ala Cys Asn Pro 
    1170                1175                1180


Gly Tyr His Ser Thr Pro Asp Arg Leu Phe Cys Val Asp Ile Asp Glu 
1185                1190                1195                1200


Cys Ser Ile Met Asn Gly Gly Cys Glu Thr Phe Cys Thr Asn Ser Glu 
                1205                1210                1215


Gly Ser Tyr Glu Cys Ser Cys Gln Pro Gly Phe Ala Leu Met Pro Asp 
            1220                1225                1230


Gln Arg Ser Cys Thr Asp Ile Asp Glu Cys Glu Asp Asn Pro Asn Ile 
        1235                1240                1245


Cys Asp Gly Gly Gln Cys Thr Asn Ile Pro Gly Glu Tyr Arg Cys Leu 
    1250                1255                1260


Cys Tyr Asp Gly Phe Met Ala Ser Glu Asp Met Lys Thr Cys Val Asp 
1265                1270                1275                1280


Val Asn Glu Cys Asp Leu Asn Pro Asn Ile Cys Leu Ser Gly Thr Cys 
                1285                1290                1295


Glu Asn Thr Lys Gly Ser Phe Ile Cys His Cys Asp Met Gly Tyr Ser 
            1300                1305                1310


Gly Lys Lys Gly Lys Thr Gly Cys Thr Asp Ile Asn Glu Cys Glu Ile 
        1315                1320                1325


Gly Ala His Asn Cys Gly Lys His Ala Val Cys Thr Asn Thr Ala Gly 
    1330                1335                1340


Ser Phe Lys Cys Ser Cys Ser Pro Gly Trp Ile Gly Asp Gly Ile Lys 
1345                1350                1355                1360


Cys Thr Asp Leu Asp Glu Cys Ser Asn Gly Thr His Met Cys Ser Gln 
                1365                1370                1375


His Ala Asp Cys Lys Asn Thr Met Gly Ser Tyr Arg Cys Leu Cys Lys 
            1380                1385                1390


Glu Gly Tyr Thr Gly Asp Gly Phe Thr Cys Thr Asp Leu Asp Glu Cys 
        1395                1400                1405


Ser Glu Asn Leu Asn Leu Cys Gly Asn Gly Gln Cys Leu Asn Ala Pro 
    1410                1415                1420


Gly Gly Tyr Arg Cys Glu Cys Asp Met Gly Phe Val Pro Ser Ala Asp 
1425                1430                1435                1440


Gly Lys Ala Cys Glu Asp Ile Asp Glu Cys Ser Leu Pro Asn Ile Cys 
                1445                1450                1455


Val Phe Gly Thr Cys His Asn Leu Pro Gly Leu Phe Arg Cys Glu Cys 
            1460                1465                1470


Glu Ile Gly Tyr Glu Leu Asp Arg Ser Gly Gly Asn Cys Thr Asp Val 
        1475                1480                1485


Asn Glu Cys Leu Asp Pro Thr Thr Cys Ile Ser Gly Asn Cys Val Asn 
    1490                1495                1500


Thr Pro Gly Ser Tyr Ile Cys Asp Cys Pro Pro Asp Phe Glu Leu Asn 
1505                1510                1515                1520


Pro Thr Arg Val Gly Cys Val Asp Thr Arg Ser Gly Asn Cys Tyr Leu 
                1525                1530                1535


Asp Ile Arg Pro Arg Gly Asp Asn Gly Asp Thr Ala Cys Ser Asn Glu 
            1540                1545                1550


Ile Gly Val Gly Val Ser Lys Ala Ser Cys Cys Cys Ser Leu Gly Lys 
        1555                1560                1565


Ala Trp Gly Thr Pro Cys Glu Met Cys Pro Ala Val Asn Thr Ser Glu 
    1570                1575                1580


Tyr Lys Ile Leu Cys Pro Gly Gly Glu Gly Phe Arg Pro Asn Pro Ile 
1585                1590                1595                1600


Thr Val Ile Leu Glu Asp Ile Asp Glu Cys Gln Glu Leu Pro Gly Leu 
                1605                1610                1615


Cys Gln Gly Gly Lys Cys Ile Asn Thr Phe Gly Ser Phe Gln Cys Arg 
            1620                1625                1630


Cys Pro Thr Gly Tyr Tyr Leu Asn Glu Asp Thr Arg Val Cys Asp Asp 
        1635                1640                1645


Val Asn Glu Cys Glu Thr Pro Gly Ile Cys Gly Pro Gly Thr Cys Tyr 
    1650                1655                1660


Asn Thr Val Gly Asn Tyr Thr Cys Ile Cys Pro Pro Asp Tyr Met Gln 
1665                1670                1675                1680


Val Asn Gly Gly Asn Asn Cys Met Asp Met Arg Arg Ser Leu Cys Tyr 
                1685                1690                1695


Arg Asn Tyr Tyr Ala Asp Asn Gln Thr Cys Asp Gly Glu Leu Leu Phe 
            1700                1705                1710


Asn Met Thr Lys Lys Met Cys Cys Cys Ser Tyr Asn Ile Gly Arg Ala 
        1715                1720                1725


Trp Asn Lys Pro Cys Glu Gln Cys Pro Ile Pro Ser Thr Asp Glu Phe 
    1730                1735                1740


Ala Thr Leu Cys Gly Ser Gln Arg Pro Gly Phe Val Ile Asp Ile Tyr 
1745                1750                1755                1760


Thr Gly Leu Pro Val Asp Ile Asp Glu Cys Arg Glu Ile Pro Gly Val 
                1765                1770                1775


Cys Glu Asn Gly Val Cys Ile Asn Met Val Gly Ser Phe Arg Cys Glu 
            1780                1785                1790


Cys Pro Val Gly Phe Phe Tyr Asn Asp Lys Leu Leu Val Cys Glu Asp 
        1795                1800                1805


Ile Asp Glu Cys Gln Asn Gly Pro Val Cys Gln Arg Asn Ala Glu Cys 
    1810                1815                1820


Ile Asn Thr Ala Gly Ser Tyr Arg Cys Asp Cys Lys Pro Gly Tyr Arg 
1825                1830                1835                1840


Phe Thr Ser Thr Gly Gln Cys Asn Asp Arg Asn Glu Cys Gln Glu Ile 
                1845                1850                1855


Pro Asn Ile Cys Ser His Gly Gln Cys Ile Asp Thr Val Gly Ser Phe 
            1860                1865                1870


Tyr Cys Leu Cys His Thr Gly Phe Lys Thr Asn Asp Asp Gln Thr Met 
        1875                1880                1885


Cys Leu Asp Ile Asn Glu Cys Glu Arg Asp Ala Cys Gly Asn Gly Thr 
    1890                1895                1900


Cys Arg Asn Thr Ile Gly Ser Phe Asn Cys Arg Cys Asn His Gly Phe 
1905                1910                1915                1920


Ile Leu Ser His Asn Asn Asp Cys Ile Asp Val Asp Glu Cys Ala Ser 
                1925                1930                1935


Gly Asn Gly Asn Leu Cys Arg Asn Gly Gln Cys Ile Asn Thr Val Gly 
            1940                1945                1950


Ser Phe Gln Cys Gln Cys Asn Glu Gly Tyr Glu Val Ala Pro Asp Gly 
        1955                1960                1965


Arg Thr Cys Val Asp Ile Asn Glu Cys Leu Leu Glu Pro Arg Lys Cys 
    1970                1975                1980


Ala Pro Gly Thr Cys Gln Asn Leu Asp Gly Ser Tyr Arg Cys Ile Cys 
1985                1990                1995                2000


Pro Pro Gly Tyr Ser Leu Gln Asn Glu Lys Cys Glu Asp Ile Asp Glu 
                2005                2010                2015


Cys Val Glu Glu Pro Glu Ile Cys Ala Leu Gly Thr Cys Ser Asn Thr 
            2020                2025                2030


Glu Gly Ser Phe Lys Cys Leu Cys Pro Glu Gly Phe Ser Leu Ser Ser 
        2035                2040                2045


Ser Gly Arg Arg Cys Gln Asp Leu Arg Met Ser Tyr Cys Tyr Ala Lys 
    2050                2055                2060


Phe Glu Gly Gly Lys Cys Ser Ser Pro Lys Ser Arg Asn His Ser Lys 
2065                2070                2075                2080


Gln Glu Cys Cys Cys Ala Leu Lys Gly Glu Gly Trp Gly Asp Pro Cys 
                2085                2090                2095


Glu Leu Cys Pro Thr Glu Pro Asp Glu Ala Phe Arg Gln Ile Cys Pro 
            2100                2105                2110


Tyr Gly Ser Gly Ile Ile Val Gly Pro Asp Asp Ser Ala Val Asp Met 
        2115                2120                2125


Asp Glu Cys Lys Glu Pro Asp Val Cys Lys His Gly Gln Cys Ile Asn 
    2130                2135                2140


Thr Asp Gly Ser Tyr Arg Cys Glu Cys Pro Phe Gly Tyr Ile Leu Ala 
2145                2150                2155                2160


Gly Asn Glu Cys Val Asp Thr Asp Glu Cys Ser Val Gly Asn Pro Cys 
                2165                2170                2175


Gly Asn Gly Thr Cys Lys Asn Val Ile Gly Gly Phe Glu Cys Thr Cys 
            2180                2185                2190


Glu Glu Gly Phe Glu Pro Gly Pro Met Met Thr Cys Glu Asp Ile Asn 
        2195                2200                2205


Glu Cys Ala Gln Asn Pro Leu Leu Cys Ala Phe Arg Cys Val Asn Thr 
    2210                2215                2220


Tyr Gly Ser Tyr Glu Cys Lys Cys Pro Val Gly Tyr Val Leu Arg Glu 
2225                2230                2235                2240


Asp Arg Arg Met Cys Lys Asp Glu Asp Glu Cys Glu Glu Gly Lys His 
                2245                2250                2255


Asp Cys Thr Glu Lys Gln Met Glu Cys Lys Asn Leu Ile Gly Thr Tyr 
            2260                2265                2270


Met Cys Ile Cys Gly Pro Gly Tyr Gln Arg Arg Pro Asp Gly Glu Gly 
        2275                2280                2285


Cys Val Asp Glu Asn Glu Cys Gln Thr Lys Pro Gly Ile Cys Glu Asn 
    2290                2295                2300


Gly Arg Cys Leu Asn Thr Arg Gly Ser Tyr Thr Cys Glu Cys Asn Asp 
2305                2310                2315                2320


Gly Phe Thr Ala Ser Pro Asn Gln Asp Glu Cys Leu Asp Asn Arg Glu 
                2325                2330                2335


Gly Tyr Cys Phe Thr Glu Val Leu Gln Asn Met Cys Gln Ile Gly Ser 
            2340                2345                2350


Ser Asn Arg Asn Pro Val Thr Lys Ser Glu Cys Cys Cys Asp Gly Gly 
        2355                2360                2365


Arg Gly Trp Gly Pro His Cys Glu Ile Cys Pro Phe Gln Gly Thr Val 
    2370                2375                2380


Ala Phe Lys Lys Leu Cys Pro His Gly Arg Gly Phe Met Thr Asn Gly 
2385                2390                2395                2400


Ala Asp Ile Asp Glu Cys Lys Val Ile His Asp Val Cys Arg Asn Gly 
                2405                2410                2415


Glu Cys Val Asn Asp Arg Gly Ser Tyr His Cys Ile Cys Lys Thr Gly 
            2420                2425                2430


Tyr Thr Pro Asp Ile Thr Gly Thr Ser Cys Val Asp Leu Asn Glu Cys 
        2435                2440                2445


Asn Gln Ala Pro Lys Pro Cys Asn Phe Ile Cys Lys Asn Thr Glu Gly 
    2450                2455                2460


Ser Tyr Gln Cys Ser Cys Pro Lys Gly Tyr Ile Leu Gln Glu Asp Gly 
2465                2470                2475                2480


Arg Ser Cys Lys Asp Leu Asp Glu Cys Ala Thr Lys Gln His Asn Cys 
                2485                2490                2495


Gln Phe Leu Cys Val Asn Thr Ile Gly Gly Phe Thr Cys Lys Cys Pro 
            2500                2505                2510


Pro Gly Phe Thr Gln His His Thr Ser Cys Ile Asp Asn Asn Glu Cys 
        2515                2520                2525


Thr Ser Asp Ile Asn Leu Cys Gly Ser Lys Gly Ile Cys Gln Asn Thr 
    2530                2535                2540


Pro Gly Ser Phe Thr Cys Glu Cys Gln Arg Gly Phe Ser Leu Asp Gln 
2545                2550                2555                2560


Thr Gly Ser Ser Cys Glu Asp Val Asp Glu Cys Glu Gly Asn His Arg 
                2565                2570                2575


Cys Gln His Gly Cys Gln Asn Ile Ile Gly Gly Tyr Arg Cys Ser Cys 
            2580                2585                2590


Pro Gln Gly Tyr Leu Gln His Tyr Gln Trp Asn Gln Cys Val Asp Glu 
        2595                2600                2605


Asn Glu Cys Leu Ser Ala His Ile Cys Gly Gly Ala Ser Cys His Asn 
    2610                2615                2620


Thr Leu Gly Ser Tyr Lys Cys Met Cys Pro Ala Gly Phe Gln Tyr Glu 
2625                2630                2635                2640


Gln Phe Ser Gly Gly Cys Gln Asp Ile Asn Glu Cys Gly Ser Ala Gln 
                2645                2650                2655


Ala Pro Cys Ser Tyr Gly Cys Ser Asn Thr Glu Gly Gly Tyr Leu Cys 
            2660                2665                2670


Gly Cys Pro Pro Gly Tyr Phe Arg Ile Gly Gln Gly His Cys Val Ser 
        2675                2680                2685


Gly Met Gly Met Gly Arg Gly Asn Pro Glu Pro Pro Val Ser Gly Glu 
    2690                2695                2700


Met Asp Asp Asn Ser Leu Ser Pro Glu Ala Cys Tyr Glu Cys Lys Ile 
2705                2710                2715                2720


Asn Gly Tyr Pro Lys Arg Gly Arg Lys Arg Arg Ser Thr Asn Glu Thr 
                2725                2730                2735


Asp Ala Ser Asn Ile Glu Asp Gln Ser Glu Thr Glu Ala Asn Val Ser 
            2740                2745                2750


Leu Ala Ser Trp Asp Val Glu Lys Thr Ala Ile Phe Ala Phe Asn Ile 
        2755                2760                2765


Ser His Val Ser Asn Lys Val Arg Ile Leu Glu Leu Leu Pro Ala Leu 
    2770                2775                2780


Thr Thr Leu Thr Asn His Asn Arg Tyr Leu Ile Glu Ser Gly Asn Glu 
2785                2790                2795                2800


Asp Gly Phe Phe Lys Ile Asn Gln Lys Glu Gly Ile Ser Tyr Leu His 
                2805                2810                2815


Phe Thr Lys Lys Lys Pro Val Ala Gly Thr Tyr Ser Leu Gln Ile Ser 
            2820                2825                2830


Ser Thr Pro Leu Tyr Lys Lys Lys Glu Leu Asn Gln Leu Glu Asp Lys 
        2835                2840                2845


Tyr Asp Lys Asp Tyr Leu Ser Gly Glu Leu Gly Asp Asn Leu Lys Met 
    2850                2855                2860


Lys Ile Gln Val Leu Leu His 
2865                2870


<210>  1039
<211>  12227
<212>  DNA
<213>  Homo sapiens

<400>  1039
accccgggca ggtggagcgc tcgcggctgc tcgcggcgag cccgggagtg atggcgaggc     60

ccctgcgggc ggccagcgcc tgaggcgccc cgccccgccc cgccccgcgc ggccctcccc    120

gcccggccct gccctgccct gctccctgcc ggcggctgcg ggcgcttcct agtccgctcg    180

ggcggccgcc caggcgaggt gcggcctccg cacaggcggg gggcgtaggc gcgcggggcc    240

cgccatggct gcgtcggagc tctacacaaa gtttgccagg gtttggatac ctgatccaga    300

ggaagtctgg aagtcagcag agctgctcaa agattataag ccaggagata aagtcctcct    360

gcttcacctc gaggaaggaa aggatttgga ataccatcta gatccaaaga ccaaggagct    420

gcctcactta cgaaatcctg acatacttgt tggtgaaaat gacctcacag ccctcagcta    480

tcttcatgag cctgctgtgc tccataatct cagagtccgc tttattgatt ccaaacttat    540

ttatacgtat tgtggtatag tcctagtagc tataaatccc tatgaacagc tgcctattta    600

tggagaagat attattaatg catacagtgg tcagaacatg ggtgatatgg atccacatat    660

ctttgcagta gctgaagaag cttacaagca aatggccaga gatgaacgaa atcagtccat    720

catcgtaagt ggagagtctg gggcaggaaa aacagtctca gctaagtatg ccatgcgata    780

ctttgcaact gtgagtggtt ctgccagtga ggccaatgtg gaggaaaagg tcttggcctc    840

caaccccatc atggagtcca ttggaaatgc taaaacaacc aggaatgata atagcagccg    900

ttttgggaag tatattgaga ttggttttga taagagatat cgaatcattg gtgccaatat    960

gagaacttat cttttagaga aatccagagt ggtattccag gcagaagagg agagaaacta   1020

tcatatcttc tatcagcttt gtgcctcagc aaagttacct gaatttaaaa tgctacgatt   1080

aggaaatgca gataacttta attacacaaa acaaggaggc agtcctgtga ttgaaggagt   1140

ggatgatgca aaggagatgg cacatactag gcaggcctgc actttgctag gaattagtga   1200

atctcatcaa atgggaattt tccgaatact tgctggcatc cttcacttag gcaatgttgg   1260

atttacatcc cgagatgcag acagctgcac aatacctccc aagcatgaac ctctctgcat   1320

cttctgtgaa ctcatgggtg tggactatga ggagatgtgt cactggctct gccatcggaa   1380

actggctact gccacagaga catacatcaa gcccatctcc aagctgcagg ccacaaatgc   1440

ccgcgatgct ttggccaagc acatctatgc caagctcttt aactggattg tagataatgt   1500

caatcaggct ctccattctg ctgtcaaaca gcactctttt attggtgtgc tagacattta   1560

cggatttgaa acatttgaga taaatagttt tgaacagttt tgcataaatt atgcaaatga   1620

aaaactacag caacaattca atatgcatgt cttcaaattg gagcaagaag aatatatgaa   1680

ggaacaaatt ccatggacac tcatagattt ttatgataat cagccttgta ttaatcttat   1740

agaatcaaaa ctaggcattc tagatttact ggatgaggaa tgcaagatgc ctaaaggcac   1800

agatgacacc tgggcccaaa aattgtacaa cacacatttg aacaaatgtg cactctttga   1860

aaagcctcgt ctatcaaaca aagctttcat catccaacat tttgctgaca aagtggaata   1920

ccagtgtgaa ggatttctcg aaaagaataa agacaccgtt tttgaagaac aaattaaagt   1980

tcttaaatca agcaagttta agatgctacc agaactattt caagatgatg agaaggccat   2040

cagtccaact tcagccacct cctcagggcg cacacccctc acacgaactc ctgcaaagcc   2100

caccaaaggc agaccaggcc aaatggccaa agagcacaag aaaacagtgg ggcatcagtt   2160

cagaaactcc ctgcacctgc ttatggagac actcaatgcc actacccctc actatgtgcg   2220

ctgtatcaag cctaatgact tcaagttccc attcacgttt gatgagaaga gggcagtgca   2280

gcagctgaga gcatgtggtg tcctggaaac catccgaatc agtgcggccg gtttcccctc   2340

acggtggact taccaagaat ttttcagccg ctaccgtgtc ctaatgaagc agaaagatgt   2400

gctgagtgac agaaagcaaa catgcaagaa tgtgttagag aaactgatac tggacaagga   2460

caaataccag tttggtaaga caaagatctt tttccgtgcc ggtcaagtgg cctatctaga   2520

aaaattgaga gctgacaaac tgagagctgc ctgcatccgg atccagaaga ccatccgagg   2580

gtggctgctg agaaagaagt acctacgcat gcggaaggca gccatcacca tgcagagata   2640

cgtgcggggc taccaggccc gatgctatgc taagtttctg cgcagaacca aggcagcaac   2700

catcattcaa aagtactggc gcatgtatgt ggtccgcagg aggtacaaga ttagacgagc   2760

tgccactatc gttcttcagt cttacttgcg aggcttcttg gccagaaata ggtatcgcaa   2820

gatactccgt gagcacaaag cagtcatcat tcagaagcga gtccggggct ggctggcccg   2880

cacacactac aagaggagca tgcatgccat catctacctt cagtgctgct tcaggcggat   2940

gatggccaag cgtgagctaa agaagctcaa aatcgaggct cgctcagtgg agcgctataa   3000

gaagctgcac atcggcatgg agaacaagat catgcagctg cagcgcaaag ttgatgagca   3060

gaacaaagac tacaaatgcc ttgtggagaa actaaccaat ctggaaggaa tatacaactc   3120

tgagactgag aaactacgaa gtgacttaga acgtcttcaa ctaagtgaag aggaagcgaa   3180

agttgccact gggcgggtcc ttagtctgca ggaagaaatt gccaagctcc ggaaagacct   3240

ggagcaaact cgttcagaga aaaaatgcat tgaggaacat gcagatcgat acaaacaaga   3300

aacagagcag ctggtatcaa atctgaagga agaaaatact ttgctgaagc aagaaaaaga   3360

agccctcaat caccgcatcg tgcagcaggc taaggagatg acagaaacta tggagaagaa   3420

gttagtagaa gaaacgaaac aactggaact cgaccttaat gatgaaaggc tgagatatca   3480

gaaccttctg aatgagttca gtcgcctgga agaaagatat gatgacctca aggaagagat   3540

gacccttatg gtgcatgtgc ctaagcctgg acacaagaga acagactcca cccacagcag   3600

caacgagtct gaatatatct ttagctctga aattgcagaa atggaagaca ttccatcaag   3660

gacagaggaa ccaagtgaga agaaggtacc tctggacatg tcattgttcc ttaagctcca   3720

gaagcgggtc acagagctgg agcaggagaa gcaggtgatg caggatgagc tggaccgcaa   3780

ggaggagcag gtgctccgca gcaaggccaa ggaagaagaa agaccacaaa ttagaggtgc   3840

agaactggaa tatgagtcac tcaagcgtca agaactagaa tcagaaaaca aaaaactgaa   3900

gaatgagcta aatgagttgc gcaaggccct cagtgagaaa agtgccccag aggtgaccgc   3960

cccaggtgca cctgcctacc gtgtcctcat ggagcagctg acctctgtga gcgaggagct   4020

tgatgtccgc aaggaggaag tcctcatctt aaggtctcaa ctggtgagcc agaaagaggc   4080

catccaaccc aaggatgaca agaatacaat gacagattcc acaatacttt tggaagatgt   4140

acaaaaaatg aaagataaag gtgaaatagc acaagcatac attggtttga aagaaacaaa   4200

tagatcatct gctctggatt accatgagtt gaatgaggat ggagagctgt ggctggttta   4260

tgaagggtta aaacaagcca acaggctcct ggaatcccag ctgcagtcac agaagaggag   4320

ccatgagaat gaggccgagg ccctccgtgg ggagatccag agcctgaagg aggagaacaa   4380

ccgacagcag cagctgctgg cccagaacct gcagctgccc ccagaggccc gcattgaggc   4440

cagcctgcag cacgagatca cccggctgac caacgaaaac ttggatttga tggaacaact   4500

tgaaaaacag gataagacgg tccgtaaact gaaaaaacaa ctgaaagtat ttgccaaaaa   4560

aattggcgaa ctagaagtgg gccagatgga gaacatatcc ccaggacaga tcattgatga   4620

acccatccga ccagtcaaca ttcccaggaa agaaaaggat ttccaaggga tgctggaata   4680

caagaaggag gatgagcaaa aacttgttaa gaacctgatt ctggaactga agccacgtgg   4740

tgtagcagtc aatttgattc caggattacc ggcatatatc ctgttcatgt gtgttcgaca   4800

tgctgactac ctgaatgatg atcagaaagt aaggtcgttg ctaacatcaa caattaacag   4860

catcaaaaaa gtattgaaga aaagaggtga tgattttgaa accgtctcct tctggctctc   4920

taacacatgc cgatttttgc actgcttgaa acagtacagt ggagaagagg gctttatgaa   4980

gcacaacaca tctcgccaga atgaacactg cctcaccaat tttgacctgg ctgagtatcg   5040

gcaggtgctg agtgacttgg ccattcagat ctaccagcag ctcgtgcggg tgttagagaa   5100

catccttcag ccaatgattg tctcaggcat gctggaacat gaaacgattc agggcgtgtc   5160

tggggtgaag cccacagggt tgagaaagcg aacctccagt atcgccgatg agggcaccta   5220

cacactggac tccatcctcc ggcagctcaa ctccttccac tcggtcatgt gtcagcatgg   5280

catggaccct gaactgatca agcaggtggt caagcagatg ttctacatca taggggccat   5340

caccctgaac aaccttctcc tgcggaagga catgtgctcc tggagtaaag gcatgcagat   5400

caggtacaat gtcagtcaac tggaagaatg gctgcgtgac aagaatctga tgaatagtgg   5460

ggctaaagaa accctggaac ctctcattca ggctgctcaa cttttgcaag tgaaaaagaa   5520

aacagatgat gatgcagaag ccatttgttc tatgtgcaat gctttaacta ctgcccagat   5580

tgtgaaagtg ttgaatttgt atactccagt taatgagttt gaagaaagag tctctgtgtc   5640

gttcattcgt actatacaga tgcgtttacg agacaggaaa gactctcccc agctgctcat   5700

ggatgctaaa cacatctttc ctgtcacctt tcctttcaac ccatcttccc tcgcactaga   5760

aaccatccag attccagcca gcctcggcct gggcttcatt tcacgggtct gaaagtgatg   5820

tccaggcaaa aattgacaat acatttcttg cccgaaataa gaacccatta tttccagtga   5880

gttactgaaa atacattttt aaagagaaag tactgattat ctcccaaatg agaagtcatt   5940

aactggaaat ctccctagaa tactttcatc actttggaaa caaagatagg ctctttcgtg   6000

ctgtgttatc tttatagcaa cactcatcct taaccaacta ggtaccgtga gtttacatac   6060

aggagaatga tggaaggaag ggaggaagga aaggaggaga aaaatgtgtc ttcagctggc   6120

agcatttatt ttaaatcctt agcactgagt ttgaatggta taaaaagtat aacttccata   6180

gatgagctgt tgttaggaag gcaccaaaga acctcctctg cactaaacag gagaatggaa   6240

agaaaagtct ccattgagta catatcatgt cagtttagta atcaattatg ttgatattgt   6300

taaactggtt caaagaaata aactggcaat atgtaaagta attcctcatt tgtgtcacta   6360

tgatatagag atattaaagg aatgttggtt tgctaaatag tatagatgtc catttgtact   6420

atagtttact gagcatttta aattgctgct acatactgtc ttcttaaaat gtaagtgata   6480

ttaggcacta caataagttt ctcttgtcaa ttctgtttac aattcaatca gatcacagtt   6540

ttaactggat tatatgcaaa tacctacaga ttcacctgca caagtagcag acactggaaa   6600

gtcatgtagt aatatgacaa aatgcttgac atttaggggt aggattagac aaagtggcta   6660

ttgttgatgt cattatttat tcaggatgta ttacattgat gtgctcatta attttccctg   6720

ggtggatatt gcgtcagggt acagtgttct gtgaagtgac ttatttttaa ctaccagatc   6780

tgattccttc agtgcatatt ttcaaccttg acaggttttc tctcttctta atttattaag   6840

aattaatctc ggctgggcgc ggtggctcac gcctgtaatc ccagcacttt gggaagccaa   6900

ggtgggcgga tcacttcagg ttaggagttg gagaccagcc tggccaacat ggcgaaaccc   6960

tgtctctact aaaaatacaa aaattagccg ggcgtggtgg cacttgcctg taatcccagc   7020

tactcgggag gctgaggcac gagaatcgat taaacctggg aggcggagat tgcaatgaga   7080

tcgaaccact gcactccagc ctgggtgaca gagagagaca ctgccttgga aaaaaaaaga   7140

atctcactca ctatctagag aggattgtca gaatattcac gattcaggtc ttgaaacttt   7200

gattatgcaa aagaaggtat ataataaata tttcattatg attcagtttt taaggctttg   7260

cagcttctat aagtgttctc agatgccact agataatttt aaaagcatca tattagaaat   7320

actttaagaa gacttatata agaaatagaa gattgttgaa ttttacagag gatttggttc   7380

attaagaccc agattctgta agttttcatt ctgaaattct agttaaacat attcaccatt   7440

tttcttagga atcttataca ataaatcctt caggttgcac aaaagcaaat tattagtttt   7500

cattagaaac tctggttctg aattacaatc ataggttata taaatttaac tgttagatgg   7560

tctataaatc ttattaaaat atgtgcaata tttatggaag tcaaacagct tcatatcagt   7620

gataaagatt gttattaaaa gataaatact gtctgttaat ttacatgggc ctcaagttcc   7680

tcgtttataa aataagagag ttggacactg attcttaaca tctcctccac atttaaaatt   7740

ctctcttctc agcccttaga ttctagagag aaaaagctgc agttactcag taagtccatt   7800

ctctgatgga aagaccagtg tgtagtgcct gtcaattcct taggattaat caaatgtaaa   7860

atcacaagtt tgtgtagctg taacctttct taaatgtaca tgatttatgt acatgctttt   7920

agaaggtcct actatatttg tattataatt agtttaagta atttttatta catcatgtat   7980

tgctttattc agtttgaata catttattta tttatttgca gtatcaacca gaaacactac   8040

caattgcatc aaattctccc agtttttcct ggttgtcaat gcggttttca atgcacaatt   8100

aagtcatagc catttggttc gtaccaaatg tgtcagaatc taacagcatc cgataggctg   8160

taagttgggg agttgctaag aaaatgcaac gtggtacagg ctgtccgcct cagccctgga   8220

aatctcccag acctccccca gcttcatcct gtgtagcacg actcaacgtg caccctgaat   8280

cttctcaggt cttccaggtc atgctgtagc tgtcactgcc atgcagccct tttttttact   8340

ccggacagct catgtactga agcgtcatga aagaaaggct gtggtctgag cccttctctc   8400

ccatctcctg tctttgtcct gtcaagtgct ggagccagag ctcctacagc tgcccttggt   8460

ggtttctcct gttcagcgat ggtggcacaa aggttctgct attccagggc tccagcttcc   8520

tcccaggtct acccagagct ccagatgggg gtctgaatta acctctcttg gtggcctgga   8580

gatttttagt cattgacaag aataccttgt aaccagggaa ccccaaggcc cagtaaatga   8640

ttctgtatac cattttcttg aaggtacaag aagattctgc cgactatggg gatctttggg   8700

ccagtttgag gattgctttc cctctgaggt tctttctctc tgtcagccac actttctcac   8760

ccaacttcag acacaccctg ccagcctttc ccctactcat tcactcttcc ccttccctca   8820

acttaatcgt ctatcccgtt gcctgctgtt tgactgtgca ctgaaggcag gtggatggag   8880

tcagtcctca gttgcccctg ctggccttcc tggtgcttac catcagccca atctttgcac   8940

agtccttgtt gttcttactt ctctgcatgc attccttcag aagatcagtc atcaactttt   9000

tcttaattcc tctgtgacac acaatgggaa ttcaaaggaa gagatcttaa aagtcacaac   9060

agttctttat cttaataatc ccctccccat tcaccttact acatgcagac tcacctcaca   9120

cccttacaac ttgaagctga aaatttaaaa gtaatttccc tttttgcagc ttttcctcag   9180

gttaaggctt tgatctgcct gagagtaact ctaaaaggag ggaagataaa tatgggataa   9240

aatccacaaa gtgtagcttc taattccttt ggaagtttaa aaaatttcca catatctgat   9300

gcttcttttg tcaggtgcag aagcacaaaa acatattccg aagccaactg atagggaatt   9360

tggggattat tgtcagtttg gagaatttgc tgtgttattt cttcatttcc atggatagct   9420

catagttggc tctttctggg tgagtaatta tgtgtaatat agatcaaatc ttttactaag   9480

gttacagcta catgttaggg gaggctatga aaatactata ttattataat ttcagtgcag   9540

tgattgttgt gagaaataac tttcatggta accctaggaa aatgggcacc tgccaccatc   9600

ctgagaagtc ctcacacaat gccctttctc tcttacacac acacacacac acatacacac   9660

acacacaccc ccgtcactaa ttcatagagt tccttagcag gcatagtcaa ggatcctctg   9720

ggtaatgtca gctgcttagt gataaaacag agccaaaact agtgcatcct gttgaaagta   9780

atgcagaaac agtacctggg tccagatatg ctttcctgcg gcgctttcct ctgttacctc   9840

gtttcatcct cacagcagca tggacggtag gtggggtcgc ttctacaatc atttctgatg   9900

atagcttggg aatagagata ggggcagtga cttgcctgat gtcgcacagc cctctggctg   9960

tcctgctttc ccatatggag cagtggtggt gtgggcacct gtgatgcagg agactttaaa  10020

aatgtcgtga ggtcacgtgc tgcccctcct ggtacgtgtg gaatgcccct ggccagcaag  10080

gggtgctttt ttatcagagt tggcagctgg catgtgggaa ccgagcaagt gctgcgtacc  10140

aagttacttg ttttaaggag accaagtgct cagcgccagg tggttttctt ttttgtcata  10200

gttacttgct ataactcagc ttgacttctg tcatgaatca gtgctctctg ggaggatgca  10260

atactctgtt tgggcattaa ttggtagcag gttgtctcaa ccaaaaagac aggaaacagc  10320

aaaagcctct ctgaaattaa gaggaaagtt actctcccca cacccatcag agtctttatt  10380

ggagccacca ggtgagctgt gcagcctgga caggcctgca gctataggcc accttcccag  10440

tttaggtcct cagcacaggg gagcccaagt cactgggtgc cttccgaggg ctgtcactgg  10500

gcaggccata tacaagtcag tgtgtgcgtg ggcactgcag tgtgtgcatg ccgtaggtgt  10560

tgatgggtgc taggaggggt gtcgtgtgca tgcgcgttga agaggatctg tattgccgtg  10620

acctctgttc atggatgagt gcattgtaat ttgttctcag gctgtgctgt gagggccgcc  10680

ttaacccttg ctcccttccc ttctagagct gccttaagtt ctccagaact tttcttctgt  10740

aaaggatatc ttgcctggaa gggatatctt gccctgtttc tcaaggtttt gtgagagttt  10800

tgactggatg tggccctgca tgaccctcct tctcctgtac ttcctctttc ctttccaaat  10860

gggaattaga actgtggggc agcaacagtc tcagagccag tgagaggcca gcttagagaa  10920

tgcttctgag ttagtgggac tctgtgtcac aagtaagcaa atgaatatat gaaagaaatt  10980

atggagataa gttagattct tggtaatact taaatgtctt gctttctact aaccttttgt  11040

tactaaaggt aaagggtata actcaaactt tttgtggaca ttcttttcaa aattttttaa  11100

gaaccctgta ctataaaagg ttgagtaaaa acaggaaagc gtgctataag ttcaaatctg  11160

ttgtattacc ctaaattaga taaaccaacc tgaattatag tagatttctc aatagatgag  11220

gaactgaaaa atactatgta aaatatcttc caaaatgctt tttatacttt ttttatttgt  11280

aatttggtct atctaaaatg ttcgttagct taacttaatg ggcgttattg gattcatatg  11340

actaacgttt cctcagtatt gtaatgcttg aaatatttga aagaaaaaat gttgtttttt  11400

agttgaaact ggtatatata attcagtgct tggcaggtta gtatattttt atgcattttt  11460

cagagtcagc agtttcaaat cttattgtta tcatgttata aaattttagc ccacatttca  11520

ggctccgtaa atcatttgag ccattatttt ttcccaacaa atggtgaatt ttttctttaa  11580

atgtggatat atatgttgta atttatgatt cctggttatg tatttttgtg ggatcctgca  11640

gtaaaattga cttttttgtg tctttgggag atttaaattg cgctaacagt gttgcgcaaa  11700

aatgagttca tgccatttaa catattgtat tttaattatt aactgtatta atttactatg  11760

aaatggacat ccttttaact aaaatggaat tgaacattgc agttttcaaa tatttttcct  11820

tgttgggtct ggaaaaggaa ttctactttg atctgcatag aaaattttga tacaattttt  11880

tgaaagttct taggtgaaac atttacccat taaaaaggaa gcagaaatac tgagacatga  11940

aaggcattat caactaactc tagactctag aacccattct agcatatctc acgtgcaatt  12000

tttaaaaata agttaataat tcatctcata tcaacaaaag cctttgaaac atgggttttc  12060

actagatatc acctagtgct aagataaaaa ccaaaacaat atcagaatta catttatgct  12120

ctaaatttgt agttgtccat tgttgtgctt agtaaatgtg tgtcattaat gctgtattct  12180

cctagctatt atggaaactt gtttaaataa agatatggat ataaaga                12227


<210>  1040
<211>  1855
<212>  PRT
<213>  Homo sapiens

<400>  1040

Met Ala Ala Ser Glu Leu Tyr Thr Lys Phe Ala Arg Val Trp Ile Pro 
1               5                   10                  15


Asp Pro Glu Glu Val Trp Lys Ser Ala Glu Leu Leu Lys Asp Tyr Lys 
            20                  25                  30


Pro Gly Asp Lys Val Leu Leu Leu His Leu Glu Glu Gly Lys Asp Leu 
        35                  40                  45


Glu Tyr His Leu Asp Pro Lys Thr Lys Glu Leu Pro His Leu Arg Asn 
    50                  55                  60


Pro Asp Ile Leu Val Gly Glu Asn Asp Leu Thr Ala Leu Ser Tyr Leu 
65                  70                  75                  80


His Glu Pro Ala Val Leu His Asn Leu Arg Val Arg Phe Ile Asp Ser 
                85                  90                  95


Lys Leu Ile Tyr Thr Tyr Cys Gly Ile Val Leu Val Ala Ile Asn Pro 
            100                 105                 110


Tyr Glu Gln Leu Pro Ile Tyr Gly Glu Asp Ile Ile Asn Ala Tyr Ser 
        115                 120                 125


Gly Gln Asn Met Gly Asp Met Asp Pro His Ile Phe Ala Val Ala Glu 
    130                 135                 140


Glu Ala Tyr Lys Gln Met Ala Arg Asp Glu Arg Asn Gln Ser Ile Ile 
145                 150                 155                 160


Val Ser Gly Glu Ser Gly Ala Gly Lys Thr Val Ser Ala Lys Tyr Ala 
                165                 170                 175


Met Arg Tyr Phe Ala Thr Val Ser Gly Ser Ala Ser Glu Ala Asn Val 
            180                 185                 190


Glu Glu Lys Val Leu Ala Ser Asn Pro Ile Met Glu Ser Ile Gly Asn 
        195                 200                 205


Ala Lys Thr Thr Arg Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr Ile 
    210                 215                 220


Glu Ile Gly Phe Asp Lys Arg Tyr Arg Ile Ile Gly Ala Asn Met Arg 
225                 230                 235                 240


Thr Tyr Leu Leu Glu Lys Ser Arg Val Val Phe Gln Ala Glu Glu Glu 
                245                 250                 255


Arg Asn Tyr His Ile Phe Tyr Gln Leu Cys Ala Ser Ala Lys Leu Pro 
            260                 265                 270


Glu Phe Lys Met Leu Arg Leu Gly Asn Ala Asp Asn Phe Asn Tyr Thr 
        275                 280                 285


Lys Gln Gly Gly Ser Pro Val Ile Glu Gly Val Asp Asp Ala Lys Glu 
    290                 295                 300


Met Ala His Thr Arg Gln Ala Cys Thr Leu Leu Gly Ile Ser Glu Ser 
305                 310                 315                 320


His Gln Met Gly Ile Phe Arg Ile Leu Ala Gly Ile Leu His Leu Gly 
                325                 330                 335


Asn Val Gly Phe Thr Ser Arg Asp Ala Asp Ser Cys Thr Ile Pro Pro 
            340                 345                 350


Lys His Glu Pro Leu Cys Ile Phe Cys Glu Leu Met Gly Val Asp Tyr 
        355                 360                 365


Glu Glu Met Cys His Trp Leu Cys His Arg Lys Leu Ala Thr Ala Thr 
    370                 375                 380


Glu Thr Tyr Ile Lys Pro Ile Ser Lys Leu Gln Ala Thr Asn Ala Arg 
385                 390                 395                 400


Asp Ala Leu Ala Lys His Ile Tyr Ala Lys Leu Phe Asn Trp Ile Val 
                405                 410                 415


Asp Asn Val Asn Gln Ala Leu His Ser Ala Val Lys Gln His Ser Phe 
            420                 425                 430


Ile Gly Val Leu Asp Ile Tyr Gly Phe Glu Thr Phe Glu Ile Asn Ser 
        435                 440                 445


Phe Glu Gln Phe Cys Ile Asn Tyr Ala Asn Glu Lys Leu Gln Gln Gln 
    450                 455                 460


Phe Asn Met His Val Phe Lys Leu Glu Gln Glu Glu Tyr Met Lys Glu 
465                 470                 475                 480


Gln Ile Pro Trp Thr Leu Ile Asp Phe Tyr Asp Asn Gln Pro Cys Ile 
                485                 490                 495


Asn Leu Ile Glu Ser Lys Leu Gly Ile Leu Asp Leu Leu Asp Glu Glu 
            500                 505                 510


Cys Lys Met Pro Lys Gly Thr Asp Asp Thr Trp Ala Gln Lys Leu Tyr 
        515                 520                 525


Asn Thr His Leu Asn Lys Cys Ala Leu Phe Glu Lys Pro Arg Leu Ser 
    530                 535                 540


Asn Lys Ala Phe Ile Ile Gln His Phe Ala Asp Lys Val Glu Tyr Gln 
545                 550                 555                 560


Cys Glu Gly Phe Leu Glu Lys Asn Lys Asp Thr Val Phe Glu Glu Gln 
                565                 570                 575


Ile Lys Val Leu Lys Ser Ser Lys Phe Lys Met Leu Pro Glu Leu Phe 
            580                 585                 590


Gln Asp Asp Glu Lys Ala Ile Ser Pro Thr Ser Ala Thr Ser Ser Gly 
        595                 600                 605


Arg Thr Pro Leu Thr Arg Thr Pro Ala Lys Pro Thr Lys Gly Arg Pro 
    610                 615                 620


Gly Gln Met Ala Lys Glu His Lys Lys Thr Val Gly His Gln Phe Arg 
625                 630                 635                 640


Asn Ser Leu His Leu Leu Met Glu Thr Leu Asn Ala Thr Thr Pro His 
                645                 650                 655


Tyr Val Arg Cys Ile Lys Pro Asn Asp Phe Lys Phe Pro Phe Thr Phe 
            660                 665                 670


Asp Glu Lys Arg Ala Val Gln Gln Leu Arg Ala Cys Gly Val Leu Glu 
        675                 680                 685


Thr Ile Arg Ile Ser Ala Ala Gly Phe Pro Ser Arg Trp Thr Tyr Gln 
    690                 695                 700


Glu Phe Phe Ser Arg Tyr Arg Val Leu Met Lys Gln Lys Asp Val Leu 
705                 710                 715                 720


Ser Asp Arg Lys Gln Thr Cys Lys Asn Val Leu Glu Lys Leu Ile Leu 
                725                 730                 735


Asp Lys Asp Lys Tyr Gln Phe Gly Lys Thr Lys Ile Phe Phe Arg Ala 
            740                 745                 750


Gly Gln Val Ala Tyr Leu Glu Lys Leu Arg Ala Asp Lys Leu Arg Ala 
        755                 760                 765


Ala Cys Ile Arg Ile Gln Lys Thr Ile Arg Gly Trp Leu Leu Arg Lys 
    770                 775                 780


Lys Tyr Leu Arg Met Arg Lys Ala Ala Ile Thr Met Gln Arg Tyr Val 
785                 790                 795                 800


Arg Gly Tyr Gln Ala Arg Cys Tyr Ala Lys Phe Leu Arg Arg Thr Lys 
                805                 810                 815


Ala Ala Thr Ile Ile Gln Lys Tyr Trp Arg Met Tyr Val Val Arg Arg 
            820                 825                 830


Arg Tyr Lys Ile Arg Arg Ala Ala Thr Ile Val Leu Gln Ser Tyr Leu 
        835                 840                 845


Arg Gly Phe Leu Ala Arg Asn Arg Tyr Arg Lys Ile Leu Arg Glu His 
    850                 855                 860


Lys Ala Val Ile Ile Gln Lys Arg Val Arg Gly Trp Leu Ala Arg Thr 
865                 870                 875                 880


His Tyr Lys Arg Ser Met His Ala Ile Ile Tyr Leu Gln Cys Cys Phe 
                885                 890                 895


Arg Arg Met Met Ala Lys Arg Glu Leu Lys Lys Leu Lys Ile Glu Ala 
            900                 905                 910


Arg Ser Val Glu Arg Tyr Lys Lys Leu His Ile Gly Met Glu Asn Lys 
        915                 920                 925


Ile Met Gln Leu Gln Arg Lys Val Asp Glu Gln Asn Lys Asp Tyr Lys 
    930                 935                 940


Cys Leu Val Glu Lys Leu Thr Asn Leu Glu Gly Ile Tyr Asn Ser Glu 
945                 950                 955                 960


Thr Glu Lys Leu Arg Ser Asp Leu Glu Arg Leu Gln Leu Ser Glu Glu 
                965                 970                 975


Glu Ala Lys Val Ala Thr Gly Arg Val Leu Ser Leu Gln Glu Glu Ile 
            980                 985                 990


Ala Lys Leu Arg Lys Asp Leu Glu Gln Thr Arg Ser Glu Lys Lys Cys 
        995                 1000                1005


Ile Glu Glu His Ala Asp Arg Tyr Lys Gln Glu Thr Glu Gln Leu Val 
    1010                1015                1020


Ser Asn Leu Lys Glu Glu Asn Thr Leu Leu Lys Gln Glu Lys Glu Ala 
1025                1030                1035                1040


Leu Asn His Arg Ile Val Gln Gln Ala Lys Glu Met Thr Glu Thr Met 
                1045                1050                1055


Glu Lys Lys Leu Val Glu Glu Thr Lys Gln Leu Glu Leu Asp Leu Asn 
            1060                1065                1070


Asp Glu Arg Leu Arg Tyr Gln Asn Leu Leu Asn Glu Phe Ser Arg Leu 
        1075                1080                1085


Glu Glu Arg Tyr Asp Asp Leu Lys Glu Glu Met Thr Leu Met Val His 
    1090                1095                1100


Val Pro Lys Pro Gly His Lys Arg Thr Asp Ser Thr His Ser Ser Asn 
1105                1110                1115                1120


Glu Ser Glu Tyr Ile Phe Ser Ser Glu Ile Ala Glu Met Glu Asp Ile 
                1125                1130                1135


Pro Ser Arg Thr Glu Glu Pro Ser Glu Lys Lys Val Pro Leu Asp Met 
            1140                1145                1150


Ser Leu Phe Leu Lys Leu Gln Lys Arg Val Thr Glu Leu Glu Gln Glu 
        1155                1160                1165


Lys Gln Val Met Gln Asp Glu Leu Asp Arg Lys Glu Glu Gln Val Leu 
    1170                1175                1180


Arg Ser Lys Ala Lys Glu Glu Glu Arg Pro Gln Ile Arg Gly Ala Glu 
1185                1190                1195                1200


Leu Glu Tyr Glu Ser Leu Lys Arg Gln Glu Leu Glu Ser Glu Asn Lys 
                1205                1210                1215


Lys Leu Lys Asn Glu Leu Asn Glu Leu Arg Lys Ala Leu Ser Glu Lys 
            1220                1225                1230


Ser Ala Pro Glu Val Thr Ala Pro Gly Ala Pro Ala Tyr Arg Val Leu 
        1235                1240                1245


Met Glu Gln Leu Thr Ser Val Ser Glu Glu Leu Asp Val Arg Lys Glu 
    1250                1255                1260


Glu Val Leu Ile Leu Arg Ser Gln Leu Val Ser Gln Lys Glu Ala Ile 
1265                1270                1275                1280


Gln Pro Lys Asp Asp Lys Asn Thr Met Thr Asp Ser Thr Ile Leu Leu 
                1285                1290                1295


Glu Asp Val Gln Lys Met Lys Asp Lys Gly Glu Ile Ala Gln Ala Tyr 
            1300                1305                1310


Ile Gly Leu Lys Glu Thr Asn Arg Ser Ser Ala Leu Asp Tyr His Glu 
        1315                1320                1325


Leu Asn Glu Asp Gly Glu Leu Trp Leu Val Tyr Glu Gly Leu Lys Gln 
    1330                1335                1340


Ala Asn Arg Leu Leu Glu Ser Gln Leu Gln Ser Gln Lys Arg Ser His 
1345                1350                1355                1360


Glu Asn Glu Ala Glu Ala Leu Arg Gly Glu Ile Gln Ser Leu Lys Glu 
                1365                1370                1375


Glu Asn Asn Arg Gln Gln Gln Leu Leu Ala Gln Asn Leu Gln Leu Pro 
            1380                1385                1390


Pro Glu Ala Arg Ile Glu Ala Ser Leu Gln His Glu Ile Thr Arg Leu 
        1395                1400                1405


Thr Asn Glu Asn Leu Asp Leu Met Glu Gln Leu Glu Lys Gln Asp Lys 
    1410                1415                1420


Thr Val Arg Lys Leu Lys Lys Gln Leu Lys Val Phe Ala Lys Lys Ile 
1425                1430                1435                1440


Gly Glu Leu Glu Val Gly Gln Met Glu Asn Ile Ser Pro Gly Gln Ile 
                1445                1450                1455


Ile Asp Glu Pro Ile Arg Pro Val Asn Ile Pro Arg Lys Glu Lys Asp 
            1460                1465                1470


Phe Gln Gly Met Leu Glu Tyr Lys Lys Glu Asp Glu Gln Lys Leu Val 
        1475                1480                1485


Lys Asn Leu Ile Leu Glu Leu Lys Pro Arg Gly Val Ala Val Asn Leu 
    1490                1495                1500


Ile Pro Gly Leu Pro Ala Tyr Ile Leu Phe Met Cys Val Arg His Ala 
1505                1510                1515                1520


Asp Tyr Leu Asn Asp Asp Gln Lys Val Arg Ser Leu Leu Thr Ser Thr 
                1525                1530                1535


Ile Asn Ser Ile Lys Lys Val Leu Lys Lys Arg Gly Asp Asp Phe Glu 
            1540                1545                1550


Thr Val Ser Phe Trp Leu Ser Asn Thr Cys Arg Phe Leu His Cys Leu 
        1555                1560                1565


Lys Gln Tyr Ser Gly Glu Glu Gly Phe Met Lys His Asn Thr Ser Arg 
    1570                1575                1580


Gln Asn Glu His Cys Leu Thr Asn Phe Asp Leu Ala Glu Tyr Arg Gln 
1585                1590                1595                1600


Val Leu Ser Asp Leu Ala Ile Gln Ile Tyr Gln Gln Leu Val Arg Val 
                1605                1610                1615


Leu Glu Asn Ile Leu Gln Pro Met Ile Val Ser Gly Met Leu Glu His 
            1620                1625                1630


Glu Thr Ile Gln Gly Val Ser Gly Val Lys Pro Thr Gly Leu Arg Lys 
        1635                1640                1645


Arg Thr Ser Ser Ile Ala Asp Glu Gly Thr Tyr Thr Leu Asp Ser Ile 
    1650                1655                1660


Leu Arg Gln Leu Asn Ser Phe His Ser Val Met Cys Gln His Gly Met 
1665                1670                1675                1680


Asp Pro Glu Leu Ile Lys Gln Val Val Lys Gln Met Phe Tyr Ile Ile 
                1685                1690                1695


Gly Ala Ile Thr Leu Asn Asn Leu Leu Leu Arg Lys Asp Met Cys Ser 
            1700                1705                1710


Trp Ser Lys Gly Met Gln Ile Arg Tyr Asn Val Ser Gln Leu Glu Glu 
        1715                1720                1725


Trp Leu Arg Asp Lys Asn Leu Met Asn Ser Gly Ala Lys Glu Thr Leu 
    1730                1735                1740


Glu Pro Leu Ile Gln Ala Ala Gln Leu Leu Gln Val Lys Lys Lys Thr 
1745                1750                1755                1760


Asp Asp Asp Ala Glu Ala Ile Cys Ser Met Cys Asn Ala Leu Thr Thr 
                1765                1770                1775


Ala Gln Ile Val Lys Val Leu Asn Leu Tyr Thr Pro Val Asn Glu Phe 
            1780                1785                1790


Glu Glu Arg Val Ser Val Ser Phe Ile Arg Thr Ile Gln Met Arg Leu 
        1795                1800                1805


Arg Asp Arg Lys Asp Ser Pro Gln Leu Leu Met Asp Ala Lys His Ile 
    1810                1815                1820


Phe Pro Val Thr Phe Pro Phe Asn Pro Ser Ser Leu Ala Leu Glu Thr 
1825                1830                1835                1840


Ile Gln Ile Pro Ala Ser Leu Gly Leu Gly Phe Ile Ser Arg Val 
                1845                1850                1855


<210>  1041
<211>  4729
<212>  DNA
<213>  Homo sapiens

<400>  1041
cgagactcag ccagaggagt acggattaag tggccgaaga aagaggagtg aggcagggga     60

gcgaggcgga cgctccgagc gcatcggact cacctgggcc ggcggcgagc ggcgagtacg    120

agtggactct tgccctccgc agcatgcgcc ccgcctgcta agtcgccgcc gtctcgccct    180

cacctagcac cgccaatccc gcctggatgg agtcccctct gggttcccat tggctcctgt    240

gagtgcttgg gtgtcgggag cctgtttttg gcgaggggaa ccaacttttg aagttcgccc    300

agaagactgc gttccagccc cagttccccg gcagcgggac ccggcgaaga cgcgaccgcg    360

gcgcgagtca ccatgggaag caaaggtgtc taccagtacc actggcaaag ccacaatgtc    420

aagcacagtg gtgtggacga catggtgcta ctgtccaaga tcacagagaa ctccatcgtg    480

gagaatctga agaagagata catggatgac tacattttta catatatagg atctgtatta    540

atctcagtca accctttcaa gcagatgcca tattttgggg aaaaggaaat tgaaatgtac    600

caaggagcgg cacagtatga aaacccacca catatctatg cccttgcaga taatatgtac    660

agaaacatga tcattgacag agagaaccag tgcgtcatta tcagtggtga aagtggtgct    720

ggaaaaacag tggctgccaa atatatcatg agctacatct ccagagtgtc tggaggaggg    780

accaaagtcc agcacgtgaa ggacattatc ctgcagtcca acccgctgct ggaggccttc    840

gggaacgcca agaccgtccg gaacaacaac tccagccgat ttggaaaata ctttgaaatc    900

cagttcagtc caggtgggga accagatggt ggaaagatct ccaacttcct tctggaaaaa    960

tctagggtgg tgatgaggaa cccaggagag cggagttttc acatatttta ccagctcatc   1020

gagggcgcct ctgcagagca gaaacacagc cttggcatca ccagcatgga ctattattac   1080

tacctgagcc tctcgggctc atacaaggtt gatgacattg acgacaggcg ggagtttcag   1140

gaaactctgc acgccatgaa tgtgattggg atctttgcag aagagcaaac gctggtgttg   1200

cagatagtgg cgggtattct ccacctggga aacatcagct tcaaagaagt tggcaactac   1260

gcggctgtgg agagtgaaga gtttttagct tttcctgcat atctgctagg gataaaccag   1320

gaccggttga aagaaaagct aacaagccgg cagatggata gcaagtgggg aggcaaatcc   1380

gaatccatcc acgtgaccct caacgtagag caggcctgtt acacccggga tgcgctcgcc   1440

aaggccctgc acgcccgggt ctttgatttc ttggtagatt ccatcaataa agccatggag   1500

aaagaccatg aagaatacaa cattggcgtc ctagacatct atggctttga aatattccag   1560

aaaaatggct ttgaacagtt ttgtatcaat tttgttaatg aaaaactgca gcagattttt   1620

attgaactga cattaaaggc agaacaggaa gaatatgttc aagagggaat aagatggaca   1680

cccattgagt actttaataa taaaatcgta tgtgacctca tagagaacaa agtgaaccct   1740

cctggcatca tgagcatcct ggatgacgtg tgcgccacga tgcatgcggt gggtgagggg   1800

gcagatcaga cgctgctcca gaaacttcag atgcagattg ggagtcatga gcacttcaac   1860

agttggaacc aaggcttcat cattcatcat tatgctggga aggtatccta tgacatggat   1920

ggcttttgtg aaaggaaccg ggatgtgctt tttatggatc tcatcgagct tatgcagagc   1980

agcgagctgc ctttcataaa gtctttattt ccggaaaatc tgcaggctga caagaaaggg   2040

cgcccaacta ctgccggaag caaaataaag aaacaagcca atgaccttgt gagcaccctg   2100

atgaaatgta cgccccacta cattcgctgc atcaagccaa acgaaaccaa gaagcccaga   2160

gactgggagg aaagcagggt aaagcatcaa gtcgaatatt tgggtctgaa agagaacatt   2220

cgagtgagaa gagctggcta tgcctatcgg cgcatcttcc aaaaattcct acagaggtat   2280

gccattctga ccaaagccac ctggccttct tggcagggag aggagaagca aggcgtcctg   2340

cacctgctgc agtcggtcaa catggacagc gaccagttcc agctggggag gagtaaagtg   2400

ttcatcaaag cccccgagtc tctatttctt ttagaagaga tgagagagag aaagtatgat   2460

gggtatgctc gagtgataca gaaatcatgg aggaaattcg tggcccggaa gaaatacgtt   2520

caaatgagag aagaagcctc agacctctta ttgaacaaga aggagagaag gagaaacagt   2580

attaacagga actttatagg ggattatatt gggatggaag agcacccaga actccagcag   2640

ttcgtgggca agagggagaa gattgatttc gcagacacag tcaccaagta tgacaggagg   2700

ttcaagggtg taaagcgaga cctgctcctt accccaaagt gcttgtactt aatcggacga   2760

gaaaaagtca aacagggccc agacaagggc ctggtgaaag aagtcctgaa gcggaaaatc   2820

gagatagaac ggatcttgtc tgtgtccctc agtactatgc aggatgacat ttttattctc   2880

catgagcaag agtatgacag tttgcttgaa tctgtcttca aaactgaatt cctaagcctc   2940

ttagcaaagc gttacgagga gaagacccag aagcaactac ctctgaaatt cagcaatacg   3000

cttgaactga agttgaaaaa ggaaaactgg ggcccctgga gtgcaggggg ctcccggcaa   3060

gtgcagttcc accaagggtt tggggacctg gctgtcctca agcccagtaa caaagtgctg   3120

caggtcagca tcggacctgg actgcccaag aactcccgtc ctaccagaag gaacactacc   3180

caaaatacag gttattccag tgggactcaa aatgccaact acccagtgag agctgcccct   3240

cctcccccag gataccatca gaacggagtc atcagaaacc agtatgtgcc atatccccat   3300

gctcctggaa gccagaggtc caatcagaaa agcctgtaca cctccatggc ccgcccgccc   3360

ttgcctcggc agcagtctac cagttcagac cgagtgtcac agacgccaga gagcctggat   3420

ttcctcaagg tcccggacca gggagctgca ggggtcagga gacaaacaac cagtcggcct   3480

cccccagcag ggggcagacc caagccccag cccaagccca agcctcaggt gccacagtgc   3540

aaggctttgt atgcctatga cgctcaggac acagacgaac tcagctttaa tgccaatgac   3600

attattgata ttatcaaaga agatccttct ggctggtgga cgggtcgact acgaggcaag   3660

cagggcctgt tccccaacaa ctatgtgacc aagatctgag gtgcccgtga ctctgacaca   3720

tggggcagag gagctccagg cacagaccag gggaggggat atttaggggc tccccttaca   3780

atccacaatg agcaattgct tctccaaggc ctggagctat tctggtacct tccccatgga   3840

ggacactgaa aaggctgggt tggggacagg gagtatcact ccataagtga tcctaaaagg   3900

tagcctcttc ataggaaccc aggaggacaa aaccaccatg cattaagatt tatttattgt   3960

atttaaacct ggtgagagga caagtgaggt ctgctcagac cttgtaggct tctatcaaaa   4020

cagcaccctg cttgctcacc aggcctagag aatggctgta ggtggccgct gacaagtgcc   4080

tttagttgaa gagcacattt ctttcatctc tcttgtccat acctgataga cacattcctc   4140

tctgccacct tccttcaggg aggacccgcc ctctgcagac tgggcttagc gtgagcaggc   4200

acttcccatg tacgtgccaa gggtaagctg gcctgctgag cccagggcga cagaggggca   4260

ctggtttaca ctttgccggg accatcaggg ccgccaagca ggtcaggggc tgggggctgg   4320

gggctgggct gctggctttg ctttctctgg gtcttcaatt agaatgtggc tggcccatat   4380

tggtttgtgt ttaaatgctg tacttactac aagaaggatc ttttttcaag ctgtacattt   4440

ataaaaacag atcatatact gtatatataa aaatcttgag atggtagaaa catgtatgaa   4500

tgtactaagt agtattccac tgtactcatt cataaggtag gttttcttac aaaactcaca   4560

ccaggtactt aaagatgtgc tctgcttttt tccaactacg gagtgtcact gctttctagg   4620

tcagtccctg cagactcttc tcaactcttt ccctatagga aacttactcc gcgtcctgcc   4680

cccacctcct aaataaataa aggaatcggc gaacaaaaaa aaaaaaaaa               4729


<210>  1042
<211>  1108
<212>  PRT
<213>  Homo sapiens

<400>  1042

Met Gly Ser Lys Gly Val Tyr Gln Tyr His Trp Gln Ser His Asn Val 
1               5                   10                  15


Lys His Ser Gly Val Asp Asp Met Val Leu Leu Ser Lys Ile Thr Glu 
            20                  25                  30


Asn Ser Ile Val Glu Asn Leu Lys Lys Arg Tyr Met Asp Asp Tyr Ile 
        35                  40                  45


Phe Thr Tyr Ile Gly Ser Val Leu Ile Ser Val Asn Pro Phe Lys Gln 
    50                  55                  60


Met Pro Tyr Phe Gly Glu Lys Glu Ile Glu Met Tyr Gln Gly Ala Ala 
65                  70                  75                  80


Gln Tyr Glu Asn Pro Pro His Ile Tyr Ala Leu Ala Asp Asn Met Tyr 
                85                  90                  95


Arg Asn Met Ile Ile Asp Arg Glu Asn Gln Cys Val Ile Ile Ser Gly 
            100                 105                 110


Glu Ser Gly Ala Gly Lys Thr Val Ala Ala Lys Tyr Ile Met Ser Tyr 
        115                 120                 125


Ile Ser Arg Val Ser Gly Gly Gly Thr Lys Val Gln His Val Lys Asp 
    130                 135                 140


Ile Ile Leu Gln Ser Asn Pro Leu Leu Glu Ala Phe Gly Asn Ala Lys 
145                 150                 155                 160


Thr Val Arg Asn Asn Asn Ser Ser Arg Phe Gly Lys Tyr Phe Glu Ile 
                165                 170                 175


Gln Phe Ser Pro Gly Gly Glu Pro Asp Gly Gly Lys Ile Ser Asn Phe 
            180                 185                 190


Leu Leu Glu Lys Ser Arg Val Val Met Arg Asn Pro Gly Glu Arg Ser 
        195                 200                 205


Phe His Ile Phe Tyr Gln Leu Ile Glu Gly Ala Ser Ala Glu Gln Lys 
    210                 215                 220


His Ser Leu Gly Ile Thr Ser Met Asp Tyr Tyr Tyr Tyr Leu Ser Leu 
225                 230                 235                 240


Ser Gly Ser Tyr Lys Val Asp Asp Ile Asp Asp Arg Arg Glu Phe Gln 
                245                 250                 255


Glu Thr Leu His Ala Met Asn Val Ile Gly Ile Phe Ala Glu Glu Gln 
            260                 265                 270


Thr Leu Val Leu Gln Ile Val Ala Gly Ile Leu His Leu Gly Asn Ile 
        275                 280                 285


Ser Phe Lys Glu Val Gly Asn Tyr Ala Ala Val Glu Ser Glu Glu Phe 
    290                 295                 300


Leu Ala Phe Pro Ala Tyr Leu Leu Gly Ile Asn Gln Asp Arg Leu Lys 
305                 310                 315                 320


Glu Lys Leu Thr Ser Arg Gln Met Asp Ser Lys Trp Gly Gly Lys Ser 
                325                 330                 335


Glu Ser Ile His Val Thr Leu Asn Val Glu Gln Ala Cys Tyr Thr Arg 
            340                 345                 350


Asp Ala Leu Ala Lys Ala Leu His Ala Arg Val Phe Asp Phe Leu Val 
        355                 360                 365


Asp Ser Ile Asn Lys Ala Met Glu Lys Asp His Glu Glu Tyr Asn Ile 
    370                 375                 380


Gly Val Leu Asp Ile Tyr Gly Phe Glu Ile Phe Gln Lys Asn Gly Phe 
385                 390                 395                 400


Glu Gln Phe Cys Ile Asn Phe Val Asn Glu Lys Leu Gln Gln Ile Phe 
                405                 410                 415


Ile Glu Leu Thr Leu Lys Ala Glu Gln Glu Glu Tyr Val Gln Glu Gly 
            420                 425                 430


Ile Arg Trp Thr Pro Ile Glu Tyr Phe Asn Asn Lys Ile Val Cys Asp 
        435                 440                 445


Leu Ile Glu Asn Lys Val Asn Pro Pro Gly Ile Met Ser Ile Leu Asp 
    450                 455                 460


Asp Val Cys Ala Thr Met His Ala Val Gly Glu Gly Ala Asp Gln Thr 
465                 470                 475                 480


Leu Leu Gln Lys Leu Gln Met Gln Ile Gly Ser His Glu His Phe Asn 
                485                 490                 495


Ser Trp Asn Gln Gly Phe Ile Ile His His Tyr Ala Gly Lys Val Ser 
            500                 505                 510


Tyr Asp Met Asp Gly Phe Cys Glu Arg Asn Arg Asp Val Leu Phe Met 
        515                 520                 525


Asp Leu Ile Glu Leu Met Gln Ser Ser Glu Leu Pro Phe Ile Lys Ser 
    530                 535                 540


Leu Phe Pro Glu Asn Leu Gln Ala Asp Lys Lys Gly Arg Pro Thr Thr 
545                 550                 555                 560


Ala Gly Ser Lys Ile Lys Lys Gln Ala Asn Asp Leu Val Ser Thr Leu 
                565                 570                 575


Met Lys Cys Thr Pro His Tyr Ile Arg Cys Ile Lys Pro Asn Glu Thr 
            580                 585                 590


Lys Lys Pro Arg Asp Trp Glu Glu Ser Arg Val Lys His Gln Val Glu 
        595                 600                 605


Tyr Leu Gly Leu Lys Glu Asn Ile Arg Val Arg Arg Ala Gly Tyr Ala 
    610                 615                 620


Tyr Arg Arg Ile Phe Gln Lys Phe Leu Gln Arg Tyr Ala Ile Leu Thr 
625                 630                 635                 640


Lys Ala Thr Trp Pro Ser Trp Gln Gly Glu Glu Lys Gln Gly Val Leu 
                645                 650                 655


His Leu Leu Gln Ser Val Asn Met Asp Ser Asp Gln Phe Gln Leu Gly 
            660                 665                 670


Arg Ser Lys Val Phe Ile Lys Ala Pro Glu Ser Leu Phe Leu Leu Glu 
        675                 680                 685


Glu Met Arg Glu Arg Lys Tyr Asp Gly Tyr Ala Arg Val Ile Gln Lys 
    690                 695                 700


Ser Trp Arg Lys Phe Val Ala Arg Lys Lys Tyr Val Gln Met Arg Glu 
705                 710                 715                 720


Glu Ala Ser Asp Leu Leu Leu Asn Lys Lys Glu Arg Arg Arg Asn Ser 
                725                 730                 735


Ile Asn Arg Asn Phe Ile Gly Asp Tyr Ile Gly Met Glu Glu His Pro 
            740                 745                 750


Glu Leu Gln Gln Phe Val Gly Lys Arg Glu Lys Ile Asp Phe Ala Asp 
        755                 760                 765


Thr Val Thr Lys Tyr Asp Arg Arg Phe Lys Gly Val Lys Arg Asp Leu 
    770                 775                 780


Leu Leu Thr Pro Lys Cys Leu Tyr Leu Ile Gly Arg Glu Lys Val Lys 
785                 790                 795                 800


Gln Gly Pro Asp Lys Gly Leu Val Lys Glu Val Leu Lys Arg Lys Ile 
                805                 810                 815


Glu Ile Glu Arg Ile Leu Ser Val Ser Leu Ser Thr Met Gln Asp Asp 
            820                 825                 830


Ile Phe Ile Leu His Glu Gln Glu Tyr Asp Ser Leu Leu Glu Ser Val 
        835                 840                 845


Phe Lys Thr Glu Phe Leu Ser Leu Leu Ala Lys Arg Tyr Glu Glu Lys 
    850                 855                 860


Thr Gln Lys Gln Leu Pro Leu Lys Phe Ser Asn Thr Leu Glu Leu Lys 
865                 870                 875                 880


Leu Lys Lys Glu Asn Trp Gly Pro Trp Ser Ala Gly Gly Ser Arg Gln 
                885                 890                 895


Val Gln Phe His Gln Gly Phe Gly Asp Leu Ala Val Leu Lys Pro Ser 
            900                 905                 910


Asn Lys Val Leu Gln Val Ser Ile Gly Pro Gly Leu Pro Lys Asn Ser 
        915                 920                 925


Arg Pro Thr Arg Arg Asn Thr Thr Gln Asn Thr Gly Tyr Ser Ser Gly 
    930                 935                 940


Thr Gln Asn Ala Asn Tyr Pro Val Arg Ala Ala Pro Pro Pro Pro Gly 
945                 950                 955                 960


Tyr His Gln Asn Gly Val Ile Arg Asn Gln Tyr Val Pro Tyr Pro His 
                965                 970                 975


Ala Pro Gly Ser Gln Arg Ser Asn Gln Lys Ser Leu Tyr Thr Ser Met 
            980                 985                 990


Ala Arg Pro Pro Leu Pro Arg Gln Gln Ser Thr Ser Ser Asp Arg Val 
        995                 1000                1005


Ser Gln Thr Pro Glu Ser Leu Asp Phe Leu Lys Val Pro Asp Gln Gly 
    1010                1015                1020


Ala Ala Gly Val Arg Arg Gln Thr Thr Ser Arg Pro Pro Pro Ala Gly 
1025                1030                1035                1040


Gly Arg Pro Lys Pro Gln Pro Lys Pro Lys Pro Gln Val Pro Gln Cys 
                1045                1050                1055


Lys Ala Leu Tyr Ala Tyr Asp Ala Gln Asp Thr Asp Glu Leu Ser Phe 
            1060                1065                1070


Asn Ala Asn Asp Ile Ile Asp Ile Ile Lys Glu Asp Pro Ser Gly Trp 
        1075                1080                1085


Trp Thr Gly Arg Leu Arg Gly Lys Gln Gly Leu Phe Pro Asn Asn Tyr 
    1090                1095                1100


Val Thr Lys Ile 
1105


<210>  1043
<211>  1680
<212>  DNA
<213>  Homo sapiens

<400>  1043
agagtgctga aggtcctgcc aacggctctc ttggcgtctc aacgttcgga tcagcagctt     60

ttttccattc tctctctcca cttcttcagt gagcagccat gagttggact gtgcctgttg    120

tgcgggccag ccagagagtg agctcggtgg gagcgaattt cctatgcctg gggatggccc    180

tgtgtccgcg tcaagcaacg cgcatcccgc tcaacggcac ctggctcttc acccccgtga    240

gcaagatggc gactgtgaag agtgagctta ttgagcgttt cacttccgag aagcccgttc    300

atcacagtaa ggtctccatc ataggaactg gatcggtggg catggcctgc gctatcagca    360

tcttattaaa aggcttgagt gatgaacttg cccttgtgga tcttgatgaa gacaaactga    420

agggtgagac gatggatctt caacatggca gccctttcac gaaaatgcca aatattgttt    480

gtagcaaaga ttactttgtc acagcaaact ccaacctagt gattatcaca gcaggtgcac    540

gccaagaaaa gggagaaacg cgccttaatt tagtccagcg aaatgtggcc atcttcaagt    600

taatgatttc cagtattgtc cagtacagcc cccactgcaa actgattatt gtttccaatc    660

cagtggatat cttaacttat gtagcttgga agttgagtgc atttcccaaa aaccgtatta    720

ttggaagcgg ctgtaatctg gatactgctc gttttcgttt cttgattgga caaaagcttg    780

gtatccattc tgaaagctgc catggatgga tcctcggaga gcatggagac tcaagtgttc    840

ctgtgtggag tggagtgaac atagctggtg tccctttgaa ggatctgaac tctgatatag    900

gaactgataa agatcctgag caatggaaaa atgtccacaa agaagtgact gcaactgcct    960

atgagattat taaaatgaaa ggttatactt cttgggccat tggcctatct gtggccgatt   1020

taacagaaag tattttgaag aatcttagga gaatacatcc agtttccacc ataattaagg   1080

gcctctatgg aatagatgaa gaagtattcc tcagtattcc ttgtatcctg ggagagaacg   1140

gtattaccaa ccttataaag ataaagctga cccctgaaga agaggcccat ctgaaaaaaa   1200

gtgcaaaaac actctgggaa attcagaata agcttaagct ttaaagttgc ctaaaactac   1260

cattccgaaa ttattgaaga gatcatagat acaggattat ataacgaaat tttgaataaa   1320

cttgaattcc taaaagatgg aaacaggaaa gtaggtagag tgattttcct atttatttag   1380

tcctccagct cttttattga gcatccacgt gctggacgat acttatttac aattcctaag   1440

tatttttggt acctctgatg tagcagcact tgccatgtta tatatatgta gttggcattt   1500

ggttcccaaa aagtaggatg taggtattta ttgtgttcta gaaattccga ctcttttcat   1560

tagatatatg ctatttcttt cattcttgct ggtttatacc tatgttcatt tatatgctgt   1620

aaaaaagtag tagcttcttc tacaatgtaa aaataaatgt acatacaaaa aaaaaaaaaa   1680


<210>  1044
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  1044

Met Ser Trp Thr Val Pro Val Val Arg Ala Ser Gln Arg Val Ser Ser 
1               5                   10                  15


Val Gly Ala Asn Phe Leu Cys Leu Gly Met Ala Leu Cys Pro Arg Gln 
            20                  25                  30


Ala Thr Arg Ile Pro Leu Asn Gly Thr Trp Leu Phe Thr Pro Val Ser 
        35                  40                  45


Lys Met Ala Thr Val Lys Ser Glu Leu Ile Glu Arg Phe Thr Ser Glu 
    50                  55                  60


Lys Pro Val His His Ser Lys Val Ser Ile Ile Gly Thr Gly Ser Val 
65                  70                  75                  80


Gly Met Ala Cys Ala Ile Ser Ile Leu Leu Lys Gly Leu Ser Asp Glu 
                85                  90                  95


Leu Ala Leu Val Asp Leu Asp Glu Asp Lys Leu Lys Gly Glu Thr Met 
            100                 105                 110


Asp Leu Gln His Gly Ser Pro Phe Thr Lys Met Pro Asn Ile Val Cys 
        115                 120                 125


Ser Lys Asp Tyr Phe Val Thr Ala Asn Ser Asn Leu Val Ile Ile Thr 
    130                 135                 140


Ala Gly Ala Arg Gln Glu Lys Gly Glu Thr Arg Leu Asn Leu Val Gln 
145                 150                 155                 160


Arg Asn Val Ala Ile Phe Lys Leu Met Ile Ser Ser Ile Val Gln Tyr 
                165                 170                 175


Ser Pro His Cys Lys Leu Ile Ile Val Ser Asn Pro Val Asp Ile Leu 
            180                 185                 190


Thr Tyr Val Ala Trp Lys Leu Ser Ala Phe Pro Lys Asn Arg Ile Ile 
        195                 200                 205


Gly Ser Gly Cys Asn Leu Asp Thr Ala Arg Phe Arg Phe Leu Ile Gly 
    210                 215                 220


Gln Lys Leu Gly Ile His Ser Glu Ser Cys His Gly Trp Ile Leu Gly 
225                 230                 235                 240


Glu His Gly Asp Ser Ser Val Pro Val Trp Ser Gly Val Asn Ile Ala 
                245                 250                 255


Gly Val Pro Leu Lys Asp Leu Asn Ser Asp Ile Gly Thr Asp Lys Asp 
            260                 265                 270


Pro Glu Gln Trp Lys Asn Val His Lys Glu Val Thr Ala Thr Ala Tyr 
        275                 280                 285


Glu Ile Ile Lys Met Lys Gly Tyr Thr Ser Trp Ala Ile Gly Leu Ser 
    290                 295                 300


Val Ala Asp Leu Thr Glu Ser Ile Leu Lys Asn Leu Arg Arg Ile His 
305                 310                 315                 320


Pro Val Ser Thr Ile Ile Lys Gly Leu Tyr Gly Ile Asp Glu Glu Val 
                325                 330                 335


Phe Leu Ser Ile Pro Cys Ile Leu Gly Glu Asn Gly Ile Thr Asn Leu 
            340                 345                 350


Ile Lys Ile Lys Leu Thr Pro Glu Glu Glu Ala His Leu Lys Lys Ser 
        355                 360                 365


Ala Lys Thr Leu Trp Glu Ile Gln Asn Lys Leu Lys Leu 
    370                 375                 380


<210>  1045
<211>  1644
<212>  DNA
<213>  Homo sapiens

<400>  1045
gctcagcatt tggggacgct ctcagctctc ggcgcacggc ccaggttatc ttgtagcata     60

gcaacttcgg atttcactct acccggagag tttcccgctt ggttgaacac attggcctca    120

ggaagcttcc ttcaaaatgt ctactgttca cgaaatcctg tgcaagctca gcttggaggg    180

tgatcactct acacccccaa gtgcatatgg gtctgtcaaa gcctatacta actttgatgc    240

tgagcgggat gctttgaaca ttgaaacagc catcaagacc aaaggtgtgg atgaggtcac    300

cattgtcaac attttgacca accgcagcaa tgcacagaga caggatattg ccttcgccta    360

ccagagaagg accaaaaagg aacttgcatc agcactgaag tcagccttat ctggccacct    420

ggagacggtg attttgggcc tattgaagac acctgctcag tatgacgctt ctgagctaaa    480

agcttccatg aaggggctgg gaaccgacga ggactctctc attgagatca tctgctccag    540

aaccaaccag gagctgcagg aaattaacag agtctacaag gaaatgtaca agactgatct    600

ggagaaggac attatttcgg acacatctgg tgacttccgc aagctgatgg ttgccctggc    660

aaagggtaga agagcagagg atggctctgt cattgattat gaactgattg accaagatgc    720

tcgggatctc tatgacgctg gagtgaagag gaaaggaact gatgttccca agtggatcag    780

catcatgacc gagcggagcg tgccccacct ccagaaagta tttgataggt acaagagtta    840

cagcccttat gacatgttgg aaagcatcag gaaagaggtt aaaggagacc tggaaaatgc    900

tttcctgaac ctggttcagt gcattcagaa caagcccctg tattttgctg atcggctgta    960

tgactccatg aagggcaagg ggacgcgaga taaggtcctg atcagaatca tggtctcccg   1020

cagtgaagtg gacatgttga aaattaggtc tgaattcaag agaaagtacg gcaagtccct   1080

gtactattat atccagcaag acactaaggg cgactaccag aaagcgctgc tgtacctgtg   1140

tggtggagat gactgaagcc cgacacggcc tgagcgtcca gaaatggtgc tcaccatgct   1200

tccagctaac aggtctagaa aaccagcttg cgaataacag tccccgtggc catccctgtg   1260

agggtgacgt tagcattacc cccaacctca ttttagttgc ctaagcattg cctggccttc   1320

ctgtctagtc tctcctgtaa gccaaagaaa tgaacattcc aaggagttgg aagtgaagtc   1380

tatgatgtga aacactttgc ctcctgtgta ctgtgtcata aacagatgaa taaactgaat   1440

ttgtacttta gaaacacgta ctttgtggcc ctgctttcaa ctgaattgtt tgaaaattaa   1500

acgtgcttgg ggttcagctg gtgaggctgt ccctgtagga agaaagctct gggactgagc   1560

tgtacagtat ggttgcccct atccaagtgt cgctatttaa gttaaattta aatgaaataa   1620

aataaaataa aatcaaaaaa aaaa                                          1644


<210>  1046
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  1046

Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp 
1               5                   10                  15


His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr Asn 
            20                  25                  30


Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys Thr 
        35                  40                  45


Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg Ser 
    50                  55                  60


Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg Thr Lys 
65                  70                  75                  80


Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu Glu 
                85                  90                  95


Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala Ser 
            100                 105                 110


Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser Leu 
        115                 120                 125


Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile Asn 
    130                 135                 140


Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile Ile 
145                 150                 155                 160


Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala Lys 
                165                 170                 175


Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile Asp 
            180                 185                 190


Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly Thr 
        195                 200                 205


Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro His 
    210                 215                 220


Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp Met 
225                 230                 235                 240


Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala Phe 
                245                 250                 255


Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe Ala Asp 
            260                 265                 270


Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val Leu 
        275                 280                 285


Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys Ile Arg 
    290                 295                 300


Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln 
305                 310                 315                 320


Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu Cys Gly 
                325                 330                 335


Gly Asp Asp 



<210>  1047
<211>  1635
<212>  DNA
<213>  Homo sapiens

<400>  1047
gctcagcatt tggggacgct ctcagctctc ggcgcacggc ccaggtaagc ggggcgcgcc     60

ctgcccgccc gcgatgggcc gccagctagc ggggtgcgga gacgctggga agaaggcttc    120

cttcaaaatg tctactgttc acgaaatcct gtgcaagctc agcttggagg gtgatcactc    180

tacaccccca agtgcatatg ggtctgtcaa agcctatact aactttgatg ctgagcggga    240

tgctttgaac attgaaacag ccatcaagac caaaggtgtg gatgaggtca ccattgtcaa    300

cattttgacc aaccgcagca atgcacagag acaggatatt gccttcgcct accagagaag    360

gaccaaaaag gaacttgcat cagcactgaa gtcagcctta tctggccacc tggagacggt    420

gattttgggc ctattgaaga cacctgctca gtatgacgct tctgagctaa aagcttccat    480

gaaggggctg ggaaccgacg aggactctct cattgagatc atctgctcca gaaccaacca    540

ggagctgcag gaaattaaca gagtctacaa ggaaatgtac aagactgatc tggagaagga    600

cattatttcg gacacatctg gtgacttccg caagctgatg gttgccctgg caaagggtag    660

aagagcagag gatggctctg tcattgatta tgaactgatt gaccaagatg ctcgggatct    720

ctatgacgct ggagtgaaga ggaaaggaac tgatgttccc aagtggatca gcatcatgac    780

cgagcggagc gtgccccacc tccagaaagt atttgatagg tacaagagtt acagccctta    840

tgacatgttg gaaagcatca ggaaagaggt taaaggagac ctggaaaatg ctttcctgaa    900

cctggttcag tgcattcaga acaagcccct gtattttgct gatcggctgt atgactccat    960

gaagggcaag gggacgcgag ataaggtcct gatcagaatc atggtctccc gcagtgaagt   1020

ggacatgttg aaaattaggt ctgaattcaa gagaaagtac ggcaagtccc tgtactatta   1080

tatccagcaa gacactaagg gcgactacca gaaagcgctg ctgtacctgt gtggtggaga   1140

tgactgaagc ccgacacggc ctgagcgtcc agaaatggtg ctcaccatgc ttccagctaa   1200

caggtctaga aaaccagctt gcgaataaca gtccccgtgg ccatccctgt gagggtgacg   1260

ttagcattac ccccaacctc attttagttg cctaagcatt gcctggcctt cctgtctagt   1320

ctctcctgta agccaaagaa atgaacattc caaggagttg gaagtgaagt ctatgatgtg   1380

aaacactttg cctcctgtgt actgtgtcat aaacagatga ataaactgaa tttgtacttt   1440

agaaacacgt actttgtggc cctgctttca actgaattgt ttgaaaatta aacgtgcttg   1500

gggttcagct ggtgaggctg tccctgtagg aagaaagctc tgggactgag ctgtacagta   1560

tggttgcccc tatccaagtg tcgctattta agttaaattt aaatgaaata aaataaaata   1620

aaatcaaaaa aaaaa                                                    1635


<210>  1048
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  1048

Met Gly Arg Gln Leu Ala Gly Cys Gly Asp Ala Gly Lys Lys Ala Ser 
1               5                   10                  15


Phe Lys Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu 
            20                  25                  30


Gly Asp His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr 
        35                  40                  45


Thr Asn Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile 
    50                  55                  60


Lys Thr Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn 
65                  70                  75                  80


Arg Ser Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg 
                85                  90                  95


Thr Lys Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His 
            100                 105                 110


Leu Glu Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp 
        115                 120                 125


Ala Ser Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp 
    130                 135                 140


Ser Leu Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu 
145                 150                 155                 160


Ile Asn Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp 
                165                 170                 175


Ile Ile Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu 
            180                 185                 190


Ala Lys Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu 
        195                 200                 205


Ile Asp Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys 
    210                 215                 220


Gly Thr Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val 
225                 230                 235                 240


Pro His Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr 
                245                 250                 255


Asp Met Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn 
            260                 265                 270


Ala Phe Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe 
        275                 280                 285


Ala Asp Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys 
    290                 295                 300


Val Leu Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys 
305                 310                 315                 320


Ile Arg Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr 
                325                 330                 335


Ile Gln Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu 
            340                 345                 350


Cys Gly Gly Asp Asp 
        355


<210>  1049
<211>  1563
<212>  DNA
<213>  Homo sapiens

<400>  1049
gctcagcatt tggggacgct ctcagctctc ggcgcacggc ccagcttcct tcaaaatgtc     60

tactgttcac gaaatcctgt gcaagctcag cttggagggt gatcactcta cacccccaag    120

tgcatatggg tctgtcaaag cctatactaa ctttgatgct gagcgggatg ctttgaacat    180

tgaaacagcc atcaagacca aaggtgtgga tgaggtcacc attgtcaaca ttttgaccaa    240

ccgcagcaat gcacagagac aggatattgc cttcgcctac cagagaagga ccaaaaagga    300

acttgcatca gcactgaagt cagccttatc tggccacctg gagacggtga ttttgggcct    360

attgaagaca cctgctcagt atgacgcttc tgagctaaaa gcttccatga aggggctggg    420

aaccgacgag gactctctca ttgagatcat ctgctccaga accaaccagg agctgcagga    480

aattaacaga gtctacaagg aaatgtacaa gactgatctg gagaaggaca ttatttcgga    540

cacatctggt gacttccgca agctgatggt tgccctggca aagggtagaa gagcagagga    600

tggctctgtc attgattatg aactgattga ccaagatgct cgggatctct atgacgctgg    660

agtgaagagg aaaggaactg atgttcccaa gtggatcagc atcatgaccg agcggagcgt    720

gccccacctc cagaaagtat ttgataggta caagagttac agcccttatg acatgttgga    780

aagcatcagg aaagaggtta aaggagacct ggaaaatgct ttcctgaacc tggttcagtg    840

cattcagaac aagcccctgt attttgctga tcggctgtat gactccatga agggcaaggg    900

gacgcgagat aaggtcctga tcagaatcat ggtctcccgc agtgaagtgg acatgttgaa    960

aattaggtct gaattcaaga gaaagtacgg caagtccctg tactattata tccagcaaga   1020

cactaagggc gactaccaga aagcgctgct gtacctgtgt ggtggagatg actgaagccc   1080

gacacggcct gagcgtccag aaatggtgct caccatgctt ccagctaaca ggtctagaaa   1140

accagcttgc gaataacagt ccccgtggcc atccctgtga gggtgacgtt agcattaccc   1200

ccaacctcat tttagttgcc taagcattgc ctggccttcc tgtctagtct ctcctgtaag   1260

ccaaagaaat gaacattcca aggagttgga agtgaagtct atgatgtgaa acactttgcc   1320

tcctgtgtac tgtgtcataa acagatgaat aaactgaatt tgtactttag aaacacgtac   1380

tttgtggccc tgctttcaac tgaattgttt gaaaattaaa cgtgcttggg gttcagctgg   1440

tgaggctgtc cctgtaggaa gaaagctctg ggactgagct gtacagtatg gttgccccta   1500

tccaagtgtc gctatttaag ttaaatttaa atgaaataaa ataaaataaa atcaaaaaaa   1560

aaa                                                                 1563


<210>  1050
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  1050

Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp 
1               5                   10                  15


His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr Asn 
            20                  25                  30


Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys Thr 
        35                  40                  45


Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg Ser 
    50                  55                  60


Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg Thr Lys 
65                  70                  75                  80


Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu Glu 
                85                  90                  95


Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala Ser 
            100                 105                 110


Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser Leu 
        115                 120                 125


Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile Asn 
    130                 135                 140


Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile Ile 
145                 150                 155                 160


Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala Lys 
                165                 170                 175


Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile Asp 
            180                 185                 190


Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly Thr 
        195                 200                 205


Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro His 
    210                 215                 220


Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp Met 
225                 230                 235                 240


Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala Phe 
                245                 250                 255


Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe Ala Asp 
            260                 265                 270


Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val Leu 
        275                 280                 285


Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys Ile Arg 
    290                 295                 300


Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln 
305                 310                 315                 320


Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu Cys Gly 
                325                 330                 335


Gly Asp Asp 



<210>  1051
<211>  515
<212>  DNA
<213>  Homo sapiens

<400>  1051
acgctacagc cgccgaaatg ttgatgccta agaagaaccg gattgccatt tatgaactcc     60

tttttaagga gggagccatg gtggccaaga aggatgtcta cacgcctaag cagccagagt    120

tggcagacaa gaatgtgccc aaccttcatg tcatgaaggc catgcagtct ctcaagtccc    180

gaggctacat gaaggaacag tttgcctgga gacatttcta ctggtacctt accaatgagg    240

gtatccacca tctccgtgat taccttcatc tgcccccgga gattgtgcct gccaccctat    300

gccacagccg tccagagact ggcaggcctc ggcctaaagg tctggagggt gagtgacctg    360

caagactcac aagaggggaa gccaacaggg atacctacag atggaatgct gtgctccctg    420

gtgctgacaa gaaagccgat gctgggagtg ggtcagcaac cgaattccag tttagaggca    480

gatttggtcg tggacatggt cagccatctc agtaa                               515


<210>  1052
<211>  15216
<212>  DNA
<213>  Homo sapiens

<400>  1052
gtctttccct ttgacaagtc gctgctgctg cagcaaaaat aaaggacgcg accgccgcag     60

cctctgcgga gccgggctcg ggtcgccgga gccgcgcccc accccgccag ctccagagcc    120

acgactaatg gctgaaggat aaatcaacat ggcaactatg attccaccag tgaagctgaa    180

atggcttgaa cacttgaaca gctcctggat tacagaggac agtgaatcta ttgctacaag    240

agagggagtt gctgttctgt attctaaact ggttagcaat aaggaagtag tacctttgcc    300

ccaacaagtt ttatgcctca aaggaccaca gttgccagac tttgaacgtg agtctctttc    360

aagtgatgag caggaccact atttggatgc ccttcttagc agccagctag cattggcaaa    420

gatggtatgt tcagattccc catttgccgg ggcacttaga aaacgactgc ttgtactcca    480

gcgtgtcttt tatgcacttt ctaataaata ccatgacaaa ggcaaggtga agcagcagca    540

gcattctccg gagagcagtt ctggttcagc agatgtccat tctgttagtg aacgcccccg    600

gtcaagcact gatgcactta tagaaatggg tgttcgaact ggtctaagtt tattatttgc    660

gcttctaaga caaagttgga tgatgcctgt gtcaggacct ggtctcagtc tttgcaacga    720

tgtcattcat actgcaattg aagttgtgag ctctttgcca ccattatcat tagcaaatga    780

aagcaagatt cctcctatgg gcttggactg cttatcgcaa gtaacaacat ttcttaaagg    840

agtcactatt cctaattctg gggcagacac tttaggtcgt agattagctt ctgagttgct    900

gcttggtttg gcagctcaac gaggctcatt gcgatatctt cttgaatgga tagaaatggc    960

tttgggggct tcggcagttg tacacaccat ggagaaaggc aaactactct caagccagga   1020

aggaatgatc agctttgact gctttatgac catattaatg cagatgaggc gttctttggg   1080

ttcatctgct gatcggagtc agtggagaga accaaccaga acatcggatg gcttgtgctc   1140

cctttacgag gcagcattat gtctctttga agaggtttgc agaatggctt ctgattattc   1200

gagaacatgt gctagcccag atagcattca gactggtgat gctcccattg tctccgaaac   1260

ctgtgaggtt tatgtttggg ggagcaatag cagccatcag ttggtagaag gtacacagga   1320

gaaaatactg caacccaaac tggctcctag tttctctgat gcacagacca ttgaagctgg   1380

acagtactgc acttttgtca tttctacgga tggctctgtt agagcttgcg ggaaaggcag   1440

ctatgggaga ctgggccttg gagactccaa taatcagtca actttaaaaa agttaacatt   1500

cgagcctcac agatccatta aaaaggtttc atcttctaaa ggatctgatg gtcacacttt   1560

agcctttacg acagaaggag aagtcttcag ttggggagat ggtgattatg ggaaactggg   1620

gcatggaaat agttcaacac agaaatatcc caagcttatt cagggacctc tacaaggaaa   1680

ggtagttgtt tgtgtgtcag ctggatacag acatagtgct gctgtcacag aggatgggga   1740

attatacaca tggggtgaag gagactttgg aagattaggt catggtgaca gcaatagtcg   1800

taacattcca acattagtaa aagacatcag caatgtagga gaggtttctt gtggcagttc   1860

acatactatt gctctgtcta aagatgggag aactgtatgg tcttttggag gaggagacaa   1920

tggtaaactt ggtcatggtg ataccaacag agtgtataaa cctaaagtta ttgaagcttt   1980

acaaggaatg ttcattcgca aagtttgtgc tgggagccag tcttcacttg ctttgacatc   2040

aacagggcag gtctatgctt ggggctgtgg agcttgtcta ggttgtggtt cttcagaagc   2100

tactgctttg agacccaagc ttattgaaga actggctgcc acaagaatag ttgatgtttc   2160

tattggagac agtcattgtt tggctctttc tcatgataat gaagtttatg cctggggcaa   2220

taactcaatg gggcaatgtg gtcagggaaa ttccacaggt cctattacta aaccaaagaa   2280

agtgagtggc ttagatggca tagctattca gcagatttcg gctggaacat cacatagtct   2340

ggcatggact gctcttccta gggacagaca agttgttgca tggcaccgac cttattgtgt   2400

agatcttgaa gagagtacct tctcacacct gcgttctttt cttgagagat actgtgataa   2460

aataaacagt gagattcccc cactcccttt cccttcatca agagaacacc acagttttct   2520

caagctgtgc ctgaagctac tttcaaatca ccttgctctt gcacttgcgg gaggggtagc   2580

taccagcatt ctcgggaggc aggcaggtcc acttcgaaat ttgctcttca gactgatgga   2640

ctcaactgtc ccagatgaaa tccaagaggt ggtaattgaa actttatcag tgggagcaac   2700

catgctgtta cctccattac gagaacggat ggaattactt cattctcttt tacctcaagg   2760

acctgataga tgggaaagct tatctaaagg acagagaatg caactggata tcatcctgac   2820

aagtttgcaa gatcataccc acgtagcctc cctacttggc tatagttcac cctctgatgc   2880

tgctgaccta tcttctgtgt gtactggcta cggaaatctg tcagatcaac cttacggcac   2940

tcagagctgc catccagata cccacctggc tgaaattttg atgaagaccc tcttaagaaa   3000

tttaggattt tatacagatc aagcatttgg agagctagaa aagaatagtg ataaatttct   3060

acttggaaca tcatcatcag aaaacagtca gcctgctcat cttcatgaac tgctatgttc   3120

actacagaaa cagctgctgg cattttgcca tatcaataac attagtgaga actcaagcag   3180

tgtggcattg cttcataaac atcttcagct tttgttgcct catgccacag atatttattc   3240

acgttctgca aatttgctca aagaaagtcc ttggaatggc agtgttggag aaaaattaag   3300

agatgtgata tacgtctcag ctgctggcag tatgctctgc cagattgtta actccctgct   3360

gttactccct gtgtcagtgg ctcggccttt attgagttac ctcctcgact tgttgccacc   3420

tcttgattgc cttaatagac tcctgccagc tgctgatctt ttagaagacc aggagttaca   3480

gtggcctctt catggagggc cagaactaat tgatcctgct ggtctgccat tacctcagcc   3540

agctcagtcc tgggtatggc ttgtggatct agaaagaaca attgctctcc ttattgggcg   3600

gtgtcttggt ggcatgcttc agggctcccc tgtgtctcca gaggaacagg acactgcata   3660

ttggatgaaa acgccactgt tcagtgacgg tgtagaaatg gacactcctc aattggataa   3720

atgtatgagt tgcctgttag aagtagcact ttctggaaat gaagaacaga agccttttga   3780

ttataaattg cggcctgaaa ttgctgtcta tgtagacttg gcattgggtt gttctaaaga   3840

gcctgcccga agcctttgga tcagcatgca ggactatgct gttagtaaag attgggacag   3900

tgcaacttta agtaatgagt cactcttgga cactgtgtct agatttgttc ttgcagctct   3960

tctgaaacac acaaatttac ttagtcaagc atgtggagaa agccgatatc aacctggtaa   4020

acacttatca gaagtgtacc gttgtgtata caaagttcga agtcgtttac ttgcttgcaa   4080

gaaccttgaa cttattcaaa caaggtcatc atcacgggac agatggatat cagaaaacca   4140

ggactctgca gatgttgatc ctcaggagca ttcatttact cgaactattg atgaagaagc   4200

tgaaatggaa gaacaggctg agagagaccg ggaagagggg catccggagc cagaggatga   4260

agaggaggaa cgggaacatg aagtgatgac agctggcaaa atctttcagt gtttcctctc   4320

agcccgtgaa gtagctcgta gccgagaccg agatagaatg aacagtgggg cagggtctgg   4380

ggctcgagct gatgatccac ctcctcagtc tcagcaagag cgaagggtca gcacagacct   4440

tcctgagggt caggatgtgt acactgctgc atgcaactcc gtgatccatc ggtgtgccct   4500

gttaatatta ggagtaagtc ctgtgataga tgagcttcag aagcgaagag aagaaggaca   4560

gttgcagcaa ccttcaacaa gtgcctctga agggggtgga cttatgacca ggagtgaaag   4620

tcttactgca gagagccggc tagtccacac aagcccaaat tatagactga tcaaatcgag   4680

gagtgaatct gatttgtctc agcctgaatc agatgaagag ggttacgcac tgagtggcag   4740

acgaaatgtt gatttggatt tggcagcatc tcacagaaag agaggtccta tgcacagtca   4800

attggaatcc ctgagtgact cttgggctcg cctgaaacat agcagagact ggttatgcaa   4860

ctcctcctat tcctttgagt cagattttga tcttaccaag tctttgggag ttcacacttt   4920

gattgaaaat gttgtaagct ttgtgagtgg agatgtgggg aatgccccag gttttaaaga   4980

gccagaggaa agtatgtcta caagtcccca ggcctccatc attgcaatgg aacagcagca   5040

gttaagggca gaacttcgtt tagaggcact tcatcagatc ctcgttctat tgtctgggat   5100

ggaagaaaaa ggtagcatct cactggcagg aagcagattg agttcaggct tccagtcctc   5160

cacactactc acgtctgtga ggctgcagtt cctagcaggg tgttttggtt taggcactgt   5220

tggacacaca ggaggcaagg gagagagtgg ccgattgcat cactatcagg atgggatcag   5280

agcagctaag agaaatattc agattgaaat ccaggtagct gtgcataaaa tttatcaaca   5340

gttgtctgct accctggaaa gagccctgca agcaaacaag catcacattg aagcccagca   5400

acgtctgctt ctggttacag tttttgccct aagtgttcat tatcaaccag tagatgtttc   5460

tttggcaatt tccactggtc tgctaaacgt attgtcacag ttgtgtggta cagacaccat   5520

gctaggacag cccctgcagt tgttgccaaa gacgggtgtt tcccagctta gcacagcttt   5580

gaaagtggcc agtacaaggt tgctccagat tctagccatc actactggga cctatgctga   5640

taaactgagt cccaaagtag ttcaatcctt gttggatcta ctctgtagtc agttgaagaa   5700

tttattgtcc caaactggtg tactacatat ggcctctttc ggagaagggg agcaagaaga   5760

cggtgaagaa gaagaaaaaa aagttgactc cagtggagaa actgagaaga aagatttcag   5820

agctgctctt aggaaacaac atgcagccga actccatcta ggggattttt tagtttttct   5880

tcgcagagtt gtatcttcaa aagcaattca atcaaaaatg gcttccccaa agtggaccga   5940

agtgcttcta aatatagcat ctcagaaatg ttcttcaggt atccctctgg ttggtaactt   6000

aagaacaagg ctccttgcac ttcatgtcct tgaagctgtg ctgccagctt gtgaatctgg   6060

tgtagaagat gatcaaatgg cccagattgt tgagcgctta ttttcccttc tctctgattg   6120

tatgtgggag acacccattg ctcaggccaa acatgctatt cagataaagg aaaaagaaca   6180

agaaataaaa ctacagaagc agggcgagtt ggaagaagaa gatgagaatc ttcctatcca   6240

agaagtatcc tttgacccgg agaaagctca gtgttgccta gtggagaatg gacagatttt   6300

aactcacggc agtggaggga aaggatatgg attggcatct acaggagtaa cttctgggtg   6360

ctatcagtgg aagttttata ttgtgaagga aaacagaggt aatgaaggca cgtgtgttgg   6420

agtttctcgc tggccagtac atgactttaa tcaccgcact acctcggata tgtggctcta   6480

tagggcctac agtggtaacc tctatcacaa tggagaacag actctcacat tgtccagctt   6540

tactcaagga gatttcatta cctgtgtgtt agacatggaa gccaggacca tttcttttgg   6600

gaaaaatgga gaggaaccca aattagcttt tgaagatgtg gatgcagcag agttgtaccc   6660

atgtgtgatg ttctatagta gcaatccagg ggaaaaggtg aaaatttgtg atatgcagat   6720

gcgtggcaca ccccgagact tacttccagg agaccctatt tgtagtccag tagcagcagt   6780

gctggctgag gccactattc agctcatccg tatccttcac cgaacagacc gttggactta   6840

ctgcattaac aaaaaaatga tggaaaggct tcacaaaatt aagatatgta ttaaagagtc   6900

aggtcagaag ctaaagaaaa gccgctcggt tcagagccga gaggaaaatg aaatgagaga   6960

ggagaaggag agcaaagagg aagagaaagg taaacatact aggcatggcc tcgctgacct   7020

ctcagagctg cagctgagga ctctttgcat agaggtgtgg cccgtgctgg ctgtgatagg   7080

aggagttgat gctggtctta gagttggagg tcggtgtgtt cacaagcaaa ctgggcgcca   7140

tgccacgctg ctgggagtgg tcaaagaggg cagcacgtct gccaaggtcc aatgggatga   7200

agcagaaatt actatcagct tcccaacttt ttggtcgcct agtgatactc cattgtataa   7260

tctggaaccc tgtgaaccat tgccgtttga tgtggcgcga ttccgaggcc tgacggcttc   7320

tgtgctgctg gacctaacat atctcactgg cgttcatgaa gacatgggca aacagagcac   7380

caaacgacat gaaaagaaac accgacatga atccgaggag aaaggggatg ttgagcagaa   7440

acctgagagt gaatccgctt tagatatgcg aacaggccta acatctgatg acgtcaaaag   7500

tcagagtacc acaagctcca aatcagaaaa tgaaatcgct tcattttctt tagatccaac   7560

actgccaagt gtggaatccc aacatcaaat aacagaaggg aaaagaaaaa atcatgaaca   7620

catgtccaaa aaccatgatg tagcccagtc agaaatcaga gcagtccagc tgtcctatct   7680

ttacctcggt gctatgaagt cacttagtgc ccttcttggc tgtagtaaat atgctgagct   7740

gttgctgata ccaaaagttc tggctgaaaa tggccacaac tcagactgtg caagttctcc   7800

agttgttcat gaagacgtgg agatgcgagc agccctgcag ttcttgatgc gacacatggt   7860

gaagcgagca gtcatgcggt cacccataaa gagagcattg ggattagctg atctggaacg   7920

agcgcaagcc atgatctata aattagtggt tcatgggctt ttggaagacc agtttggggg   7980

caaaattaag caagagattg atcaacaagc tgaagaaagt gaccctgccc agcaggcaca   8040

gacaccagtt actactagcc catcagcctc aagcacgacc tcctttatga gcagctctct   8100

ggaggacacc acaactgcca ccactccagt cactgacaca gaaacagtgc ctgcatccga   8160

gtccccggga gtgatgcctc ttagtcttct caggcaaatg ttctctagtt acccaactac   8220

cactgtactt cccacacgtc gggcacagac tcctccaata tcttcgttac caacctctcc   8280

ttctgatgaa gtaggaagga ggcaaagttt aacttctcct gattcccagt cagcaaggcc   8340

agctaaccgc acagccttgt cagacccaag cagtagactt tcaacttctc ctcctcctcc   8400

agcaattgca gttcccttgc tggaaatggg gttctctctt cggcagattg ccaaagccat   8460

ggaagctaca ggtgctaggg gagaggctga tgcccagaat atcactgtcc ttgccatgtg   8520

gatgatagag caccctgggc atgaggatga agaggagccc cagtcgggca gcacagcaga   8580

ctctaggcct ggagcagccg ttctaggcag tggcgggaag tcaaatgatc cctgttattt   8640

gcagtcacct ggagacatac catcagctga tgctgctgaa atggaggaag gttttagtga   8700

aagccctgat aatttggatc atacagagaa tgcagcttct ggaagtggac catcagctag   8760

aggtcgctca gcggtaacaa gaagacacaa gtttgactta gctgctcgca cactgctagc   8820

aagagcagcg ggattatacc gctctgtgca ggcccacagg aatcaaagtc ggagagaagg   8880

aatatctttg cagcaagacc caggggcgtt gtatgacttt aatttagatg aggaattgga   8940

aattgatctt gatgatgagg cgatggaagc tatgtttgga caagacctga ccagtgacaa   9000

tgatattctg ggaatgtgga tcccagaggt actggattgg cctacctggc atgtttgtga   9060

gtctgaagac agggaagaag tggtggtgtg tgaactgtgt gaatgcagcg tcgtcagctt   9120

caatcagcac atgaagagaa accatccagg ctgtgggcgc agtgcaaacc gccagggcta   9180

tcgcagcaat ggttcctatg tggatggctg gtttggcggt gaatgtggga gtggaaatcc   9240

gtactacctg ttatgtggca cctgcaggga gaagtactta gccatgaaga ccaaatctaa   9300

gtcaacaagt tctgaaaggt acaagggaca agctccagat ctaattggca agcaagacag   9360

tgtgtatgaa gaagactggg acatgttgga tgttgatgaa gatgaaaagc taactggtga   9420

agaagaattt gaattacttg ctggaccgct tggtttaaat gaccggcgca ttgtaccaga   9480

accagttcag ttccctgaca gcgatccact gggagcatca gtagcaatgg tcacagccac   9540

caacagtatg gaagagactc tgatgcaaat aggttgccat ggctccgtag aaaagagctc   9600

ctctgggaga ataacgttag gagagcaggc agctgcccta gcaaaccctc atgaccgtgt   9660

ggtggcttta aggagagtga ctgctgctgc tcaggttctt ctggccagaa ccatggtcat   9720

gagagcgctg tctcttctct cagtcagtgg ttccagttgt agcctggctg ctggtcttga   9780

gtctctgggg ctaacagata tccgaacgct agttcgatta atgtgcttgg cagcagcagg   9840

gagagctggc ctctccacca gcccttctgc catggctagc acctcagaac gatcacgagg   9900

tgggcatagc aaggctaaca agcctatctc ttgcctggcc tatttgagca cagcagtggg   9960

atgtctggca tcaaatgctc ctagtgctgc caaactgctt gtacagttgt gtacacagaa  10020

cttgatttct gctgcaacag gtgtaaatct aaccacagtt gatgactcaa ttcagcgaaa  10080

gtttctaccc agctttctcc gaggaattgc tgaagagaac aagcttgtga cctccccaaa  10140

ctttgttgta acacaggccc ttgtggcatt gctagcagac aaaggggcca aactaagacc  10200

taactatgat aagtcagaag ttgaaaagaa aggccctctg gagttggcta atgccctggc  10260

agcctgctgc ctctcctcca ggctgtcctc acagcatcgg caatgggcag ctcagcaact  10320

cgtgcgcact cttgctgcac acgaccgtga caaccaaact actctgcaga cacttgctga  10380

tatgggagga gatcttagaa aatgctcctt tatcaaattg gaggctcatc agaacagagt  10440

aatgacatgt gtttggtgta ataaaaaagg tcttttggct acaagtggca atgatggcac  10500

catccgcgta tggaatgtta ccaagaagca atattcactg caacagacct gtgtgttcaa  10560

cagattggaa ggggatgctg aggaaagcct gggatcaccc agtgatccaa gtttctcacc  10620

agtttcctgg agtatcagtg gcaaatatct agcaggcgct ttggaaaaga tggtgaatat  10680

ctggcaagtt aatggaggaa aaggattagt agatattcag cctcattggg tatctgccct  10740

ggcttggcca gaagagggtc cggctacagc ctggtcagga gagtctccag aattgttgtt  10800

ggtgggacgg atggatggat ctctgggact gattgaagtt gttgatgtgt ccaccatgca  10860

ccgtcgagaa ttggagcatt gctatcgaaa ggatgtgtct gttacttgca ttgcatggtt  10920

cagtgaagac agaccatttg cagtgggata ttttgatgga aaactgttac tgggaacaaa  10980

ggaaccactt gagaaaggag gcattgttct aattgatgca cataaggata ctcttattag  11040

catgaagtgg gaccctacag gtcatattct tatgacatgt gccaaagaag acagtgtgaa  11100

actctggggc tctatttcgg gatgctggtg ctgtctacat tcactctgcc atccatctat  11160

tgtaaatggc attgcttggt gccgccttcc agggaaagga tccaagttgc agttactgat  11220

ggctactggc tgtcagagtg gcttagtatg tgtttggcgc attcctcaag atactacaca  11280

gaccaatgtg actagtgcag aaggatggtg ggagcaggaa tcaaattgcc aggatggata  11340

taggaaatca tcaggagcca agtgtgttta tcagctgcgg ggacacatca ctcctgttcg  11400

gactgttgcc tttagttctg atgggttggc cctggtgtct ggtggactag gtgggctcat  11460

gaacatttgg tctttaaggg atggctctgt cttgcaaact gttgtgatag gctctggagc  11520

tattcagacc acagtatgga ttccagaagt tggagtagct gcttgctcaa atagatcaaa  11580

ggatgttttg gtcgtgaatt gtacagcaga atgggcagct gccaatcatg ttttggcaac  11640

ctgtaggaca gcattgaaac agcagggtgt tctgggattg aacatggctc cctgcatgag  11700

agcatttttg gagcggctcc ccatgatgct tcaggagcag tatgcctatg aaaagcctca  11760

tgtggtttgt ggtgaccaac ttgttcatag cccctatatg caatgcttgg cttcccttgc  11820

tgtgggactt catctggatc agctgttgtg taaccctcca gtgccaccac accaccagaa  11880

ctgtctccct gaccctgcat cctggaatcc aaatgaatgg gcctggttag aatgtttctc  11940

aaccactata aaagctgccg aagccctgac caatggagcc cagtttccag aatcttttac  12000

cgttccagat ctagaacctg ttccagagga tgaacttgta tttctaatgg ataacagtaa  12060

atggattaac ggcatggatg aacaaattat gtcttgggca acttccagac ctgaggactg  12120

gcacctggga ggtaaatgtg atgtctactt atggggtgct ggtaggcatg gacagctggc  12180

agaagctgga agaaatgtaa tggtacctgc agcagctccc tcattctcac aggcccaaca  12240

ggtcatttgt ggtcagaatt gtacctttgt catccaggcc aatggcacag tgttggcttg  12300

tggggaagga agttatggca gattaggaca aggaaattca gatgaccttc atgtgctgac  12360

agttatttca gccttacaag gctttgtggt gacccagctg gtgacttcct gtggttctga  12420

tgggcactct atggccctaa ctgaaagtgg tgaggtcttt agctggggag atggtgacta  12480

tggtaaactt ggccatggga acagcgacag gcagcggcgg cccaggcaga tcgaggcctt  12540

acaaggagaa gaagtggtgc agatgtcttg tggcttcaag cactcagcag tggtcacttc  12600

agatggcaaa ctgttcacct ttgggaatgg tgactatggt cgtctgggtc ttggaaatac  12660

ctctaacaaa aaacttccag agagagtgac tgcactggag ggatatcaga ttggacaggt  12720

ggcctgtgga ttaaaccaca ctttggcagt gtcagcagat ggttccatgg tgtgggcttt  12780

tggagatgga gactatggaa aactaggctt aggaaattcc actgcaaaat cttcacctca  12840

gaaaattgac gtcctttgtg gaattggaat aaaaaaggtt gcttgtggaa ctcagttttc  12900

tgttgctttg accaaagatg gtcatgtgta tacctttggt caagatcgcc tgataggctt  12960

gccagagggg cgtgctcgca atcacaatcg accgcaacaa atccctgtcc tggctggagt  13020

aatcatagaa gatgtggcag ttggagctga acacacactt gctttggcat caaatggaga  13080

tgtgtatgcc tgggggagca attcagaagg gcagctcggc ttaggccata ccaaccatgt  13140

tcgagaacca accctggtaa caggtctgca agggaaaaat gttcggcaga tctcggctgg  13200

ccgctgccac agtgctgcat ggacagcacc acctgtccca ccaagagcac caggtgtgtc  13260

agtacctctg cagctgggcc tgcctgacac agtgcccccc cagtatgggg cgctgagaga  13320

agtcagcatt cacacggtgc gggccaggct ccggctgctc taccacttct ctgacctcat  13380

gtactcatcc tggagactgc tgaaccttag ccccaacaac cagaacagca catcccatta  13440

taatgctgga acttggggca ttgtacaggg acaacttcgg cctttgttag ccccaagagt  13500

ctacactctg ccaatggtgc gctccatagg aaaaaccatg gttcaaggca aaaactatgg  13560

acctcagata actgtaaaga ggatatcaac cagaggacgg aagtgtaagc ctatttttgt  13620

ccaaatagcg agacaagtag ttaagctgaa tgcttcagac ctccgcctgc cttcccgagc  13680

gtggaaggtt aagctggttg gagaaggggc tgatgatgct ggaggagtgt ttgatgacac  13740

catcacagag atgtgccagg aacttgaaac tggtattgtt gaccttctta taccctctcc  13800

caatgccacc gcagaagtgg gttacaatag ggacaggttc ctttttaacc cttctgcctg  13860

cctcgatgaa cacttaatgc agtttaagtt tttaggaatt ttaatggggg ttgccattcg  13920

cacaaagaag cctctggacc tccacttggc ccctctggtg tggaagcagc tgtgctgtgt  13980

cccactcacc ctagaggacc tggaggaggt ggatctgctc tacgtgcaga ctctcaacag  14040

cattcttcac attgaagaca gtgggattac cgaggagagt ttccatgaga tgattcctct  14100

tgattctttt gttggccaga gtgctgatgg caaaatggtt cctataatcc ctggtggaaa  14160

tagtatccca ctcacatttt ccaacaggaa ggaatatgtg gagagggcca ttgaatatcg  14220

acttcatgag atggacagac aggtggctgc agtccgagaa gggatgtcct ggattgttcc  14280

tgtgccgctg ctgtccctcc tcacagcaaa acaactggag cagatggtgt gtgggatgcc  14340

cgagatctct gtggaagtct tgaagaaagt ggtgcggtac cgtgaggtgg atgagcagca  14400

tcagctggtg cagtggttct ggcacacgct ggaagagttc tccaatgagg agcgggtgct  14460

tttcatgagg tttgtgtcag gaagatctcg actaccagcc aacactgctg acatttctca  14520

gagatttcaa atcatgaagg ttgataggcc ttacgacagt ctgcctacct cacagacctg  14580

cttcttccag ctgaggctgc ccccgtactc cagccagctg gtcatggccg agcgcctgcg  14640

ctatgccatc aacaactgcc gctcaatcga catggacaac tacatgctct cgagaaacgt  14700

ggacaacgcc gagggctccg acactgacta ctgaccgtgc gggtgctctc accctccctt  14760

ctctccctca ataatgctca cttctgattt gatgttgata tacttttatg gtaactacat  14820

agatgttata agaacataaa ccaacattat aaacaatggc cacatttagt tactctaaat  14880

gtaacaaaga aattagatgt ttttattttt ctgtgattgt acaaaaacaa caaaaacgaa  14940

gtgctctcag tcaggttttt ccctccatat ttttggtcac ttttgataag tttgcatgaa  15000

accattttgg tgcattttta gttgggaatg gtacattttt gtaaatccac ccagtgaaca  15060

tgaaattgta cattgtgtat aattgttcat tagaaaggac agttttacat gaatattcat  15120

atatttattt tgttttaatt tgaattgcct gttcagggtt ccttatgcag agaaataaag  15180

cagattcagg aattggaaaa aaaaaaaaaa aaaaaa                            15216


<210>  1053
<211>  4861
<212>  PRT
<213>  Homo sapiens

<400>  1053

Met Ala Thr Met Ile Pro Pro Val Lys Leu Lys Trp Leu Glu His Leu 
1               5                   10                  15


Asn Ser Ser Trp Ile Thr Glu Asp Ser Glu Ser Ile Ala Thr Arg Glu 
            20                  25                  30


Gly Val Ala Val Leu Tyr Ser Lys Leu Val Ser Asn Lys Glu Val Val 
        35                  40                  45


Pro Leu Pro Gln Gln Val Leu Cys Leu Lys Gly Pro Gln Leu Pro Asp 
    50                  55                  60


Phe Glu Arg Glu Ser Leu Ser Ser Asp Glu Gln Asp His Tyr Leu Asp 
65                  70                  75                  80


Ala Leu Leu Ser Ser Gln Leu Ala Leu Ala Lys Met Val Cys Ser Asp 
                85                  90                  95


Ser Pro Phe Ala Gly Ala Leu Arg Lys Arg Leu Leu Val Leu Gln Arg 
            100                 105                 110


Val Phe Tyr Ala Leu Ser Asn Lys Tyr His Asp Lys Gly Lys Val Lys 
        115                 120                 125


Gln Gln Gln His Ser Pro Glu Ser Ser Ser Gly Ser Ala Asp Val His 
    130                 135                 140


Ser Val Ser Glu Arg Pro Arg Ser Ser Thr Asp Ala Leu Ile Glu Met 
145                 150                 155                 160


Gly Val Arg Thr Gly Leu Ser Leu Leu Phe Ala Leu Leu Arg Gln Ser 
                165                 170                 175


Trp Met Met Pro Val Ser Gly Pro Gly Leu Ser Leu Cys Asn Asp Val 
            180                 185                 190


Ile His Thr Ala Ile Glu Val Val Ser Ser Leu Pro Pro Leu Ser Leu 
        195                 200                 205


Ala Asn Glu Ser Lys Ile Pro Pro Met Gly Leu Asp Cys Leu Ser Gln 
    210                 215                 220


Val Thr Thr Phe Leu Lys Gly Val Thr Ile Pro Asn Ser Gly Ala Asp 
225                 230                 235                 240


Thr Leu Gly Arg Arg Leu Ala Ser Glu Leu Leu Leu Gly Leu Ala Ala 
                245                 250                 255


Gln Arg Gly Ser Leu Arg Tyr Leu Leu Glu Trp Ile Glu Met Ala Leu 
            260                 265                 270


Gly Ala Ser Ala Val Val His Thr Met Glu Lys Gly Lys Leu Leu Ser 
        275                 280                 285


Ser Gln Glu Gly Met Ile Ser Phe Asp Cys Phe Met Thr Ile Leu Met 
    290                 295                 300


Gln Met Arg Arg Ser Leu Gly Ser Ser Ala Asp Arg Ser Gln Trp Arg 
305                 310                 315                 320


Glu Pro Thr Arg Thr Ser Asp Gly Leu Cys Ser Leu Tyr Glu Ala Ala 
                325                 330                 335


Leu Cys Leu Phe Glu Glu Val Cys Arg Met Ala Ser Asp Tyr Ser Arg 
            340                 345                 350


Thr Cys Ala Ser Pro Asp Ser Ile Gln Thr Gly Asp Ala Pro Ile Val 
        355                 360                 365


Ser Glu Thr Cys Glu Val Tyr Val Trp Gly Ser Asn Ser Ser His Gln 
    370                 375                 380


Leu Val Glu Gly Thr Gln Glu Lys Ile Leu Gln Pro Lys Leu Ala Pro 
385                 390                 395                 400


Ser Phe Ser Asp Ala Gln Thr Ile Glu Ala Gly Gln Tyr Cys Thr Phe 
                405                 410                 415


Val Ile Ser Thr Asp Gly Ser Val Arg Ala Cys Gly Lys Gly Ser Tyr 
            420                 425                 430


Gly Arg Leu Gly Leu Gly Asp Ser Asn Asn Gln Ser Thr Leu Lys Lys 
        435                 440                 445


Leu Thr Phe Glu Pro His Arg Ser Ile Lys Lys Val Ser Ser Ser Lys 
    450                 455                 460


Gly Ser Asp Gly His Thr Leu Ala Phe Thr Thr Glu Gly Glu Val Phe 
465                 470                 475                 480


Ser Trp Gly Asp Gly Asp Tyr Gly Lys Leu Gly His Gly Asn Ser Ser 
                485                 490                 495


Thr Gln Lys Tyr Pro Lys Leu Ile Gln Gly Pro Leu Gln Gly Lys Val 
            500                 505                 510


Val Val Cys Val Ser Ala Gly Tyr Arg His Ser Ala Ala Val Thr Glu 
        515                 520                 525


Asp Gly Glu Leu Tyr Thr Trp Gly Glu Gly Asp Phe Gly Arg Leu Gly 
    530                 535                 540


His Gly Asp Ser Asn Ser Arg Asn Ile Pro Thr Leu Val Lys Asp Ile 
545                 550                 555                 560


Ser Asn Val Gly Glu Val Ser Cys Gly Ser Ser His Thr Ile Ala Leu 
                565                 570                 575


Ser Lys Asp Gly Arg Thr Val Trp Ser Phe Gly Gly Gly Asp Asn Gly 
            580                 585                 590


Lys Leu Gly His Gly Asp Thr Asn Arg Val Tyr Lys Pro Lys Val Ile 
        595                 600                 605


Glu Ala Leu Gln Gly Met Phe Ile Arg Lys Val Cys Ala Gly Ser Gln 
    610                 615                 620


Ser Ser Leu Ala Leu Thr Ser Thr Gly Gln Val Tyr Ala Trp Gly Cys 
625                 630                 635                 640


Gly Ala Cys Leu Gly Cys Gly Ser Ser Glu Ala Thr Ala Leu Arg Pro 
                645                 650                 655


Lys Leu Ile Glu Glu Leu Ala Ala Thr Arg Ile Val Asp Val Ser Ile 
            660                 665                 670


Gly Asp Ser His Cys Leu Ala Leu Ser His Asp Asn Glu Val Tyr Ala 
        675                 680                 685


Trp Gly Asn Asn Ser Met Gly Gln Cys Gly Gln Gly Asn Ser Thr Gly 
    690                 695                 700


Pro Ile Thr Lys Pro Lys Lys Val Ser Gly Leu Asp Gly Ile Ala Ile 
705                 710                 715                 720


Gln Gln Ile Ser Ala Gly Thr Ser His Ser Leu Ala Trp Thr Ala Leu 
                725                 730                 735


Pro Arg Asp Arg Gln Val Val Ala Trp His Arg Pro Tyr Cys Val Asp 
            740                 745                 750


Leu Glu Glu Ser Thr Phe Ser His Leu Arg Ser Phe Leu Glu Arg Tyr 
        755                 760                 765


Cys Asp Lys Ile Asn Ser Glu Ile Pro Pro Leu Pro Phe Pro Ser Ser 
    770                 775                 780


Arg Glu His His Ser Phe Leu Lys Leu Cys Leu Lys Leu Leu Ser Asn 
785                 790                 795                 800


His Leu Ala Leu Ala Leu Ala Gly Gly Val Ala Thr Ser Ile Leu Gly 
                805                 810                 815


Arg Gln Ala Gly Pro Leu Arg Asn Leu Leu Phe Arg Leu Met Asp Ser 
            820                 825                 830


Thr Val Pro Asp Glu Ile Gln Glu Val Val Ile Glu Thr Leu Ser Val 
        835                 840                 845


Gly Ala Thr Met Leu Leu Pro Pro Leu Arg Glu Arg Met Glu Leu Leu 
    850                 855                 860


His Ser Leu Leu Pro Gln Gly Pro Asp Arg Trp Glu Ser Leu Ser Lys 
865                 870                 875                 880


Gly Gln Arg Met Gln Leu Asp Ile Ile Leu Thr Ser Leu Gln Asp His 
                885                 890                 895


Thr His Val Ala Ser Leu Leu Gly Tyr Ser Ser Pro Ser Asp Ala Ala 
            900                 905                 910


Asp Leu Ser Ser Val Cys Thr Gly Tyr Gly Asn Leu Ser Asp Gln Pro 
        915                 920                 925


Tyr Gly Thr Gln Ser Cys His Pro Asp Thr His Leu Ala Glu Ile Leu 
    930                 935                 940


Met Lys Thr Leu Leu Arg Asn Leu Gly Phe Tyr Thr Asp Gln Ala Phe 
945                 950                 955                 960


Gly Glu Leu Glu Lys Asn Ser Asp Lys Phe Leu Leu Gly Thr Ser Ser 
                965                 970                 975


Ser Glu Asn Ser Gln Pro Ala His Leu His Glu Leu Leu Cys Ser Leu 
            980                 985                 990


Gln Lys Gln Leu Leu Ala Phe Cys His Ile Asn Asn Ile Ser Glu Asn 
        995                 1000                1005


Ser Ser Ser Val Ala Leu Leu His Lys His Leu Gln Leu Leu Leu Pro 
    1010                1015                1020


His Ala Thr Asp Ile Tyr Ser Arg Ser Ala Asn Leu Leu Lys Glu Ser 
1025                1030                1035                1040


Pro Trp Asn Gly Ser Val Gly Glu Lys Leu Arg Asp Val Ile Tyr Val 
                1045                1050                1055


Ser Ala Ala Gly Ser Met Leu Cys Gln Ile Val Asn Ser Leu Leu Leu 
            1060                1065                1070


Leu Pro Val Ser Val Ala Arg Pro Leu Leu Ser Tyr Leu Leu Asp Leu 
        1075                1080                1085


Leu Pro Pro Leu Asp Cys Leu Asn Arg Leu Leu Pro Ala Ala Asp Leu 
    1090                1095                1100


Leu Glu Asp Gln Glu Leu Gln Trp Pro Leu His Gly Gly Pro Glu Leu 
1105                1110                1115                1120


Ile Asp Pro Ala Gly Leu Pro Leu Pro Gln Pro Ala Gln Ser Trp Val 
                1125                1130                1135


Trp Leu Val Asp Leu Glu Arg Thr Ile Ala Leu Leu Ile Gly Arg Cys 
            1140                1145                1150


Leu Gly Gly Met Leu Gln Gly Ser Pro Val Ser Pro Glu Glu Gln Asp 
        1155                1160                1165


Thr Ala Tyr Trp Met Lys Thr Pro Leu Phe Ser Asp Gly Val Glu Met 
    1170                1175                1180


Asp Thr Pro Gln Leu Asp Lys Cys Met Ser Cys Leu Leu Glu Val Ala 
1185                1190                1195                1200


Leu Ser Gly Asn Glu Glu Gln Lys Pro Phe Asp Tyr Lys Leu Arg Pro 
                1205                1210                1215


Glu Ile Ala Val Tyr Val Asp Leu Ala Leu Gly Cys Ser Lys Glu Pro 
            1220                1225                1230


Ala Arg Ser Leu Trp Ile Ser Met Gln Asp Tyr Ala Val Ser Lys Asp 
        1235                1240                1245


Trp Asp Ser Ala Thr Leu Ser Asn Glu Ser Leu Leu Asp Thr Val Ser 
    1250                1255                1260


Arg Phe Val Leu Ala Ala Leu Leu Lys His Thr Asn Leu Leu Ser Gln 
1265                1270                1275                1280


Ala Cys Gly Glu Ser Arg Tyr Gln Pro Gly Lys His Leu Ser Glu Val 
                1285                1290                1295


Tyr Arg Cys Val Tyr Lys Val Arg Ser Arg Leu Leu Ala Cys Lys Asn 
            1300                1305                1310


Leu Glu Leu Ile Gln Thr Arg Ser Ser Ser Arg Asp Arg Trp Ile Ser 
        1315                1320                1325


Glu Asn Gln Asp Ser Ala Asp Val Asp Pro Gln Glu His Ser Phe Thr 
    1330                1335                1340


Arg Thr Ile Asp Glu Glu Ala Glu Met Glu Glu Gln Ala Glu Arg Asp 
1345                1350                1355                1360


Arg Glu Glu Gly His Pro Glu Pro Glu Asp Glu Glu Glu Glu Arg Glu 
                1365                1370                1375


His Glu Val Met Thr Ala Gly Lys Ile Phe Gln Cys Phe Leu Ser Ala 
            1380                1385                1390


Arg Glu Val Ala Arg Ser Arg Asp Arg Asp Arg Met Asn Ser Gly Ala 
        1395                1400                1405


Gly Ser Gly Ala Arg Ala Asp Asp Pro Pro Pro Gln Ser Gln Gln Glu 
    1410                1415                1420


Arg Arg Val Ser Thr Asp Leu Pro Glu Gly Gln Asp Val Tyr Thr Ala 
1425                1430                1435                1440


Ala Cys Asn Ser Val Ile His Arg Cys Ala Leu Leu Ile Leu Gly Val 
                1445                1450                1455


Ser Pro Val Ile Asp Glu Leu Gln Lys Arg Arg Glu Glu Gly Gln Leu 
            1460                1465                1470


Gln Gln Pro Ser Thr Ser Ala Ser Glu Gly Gly Gly Leu Met Thr Arg 
        1475                1480                1485


Ser Glu Ser Leu Thr Ala Glu Ser Arg Leu Val His Thr Ser Pro Asn 
    1490                1495                1500


Tyr Arg Leu Ile Lys Ser Arg Ser Glu Ser Asp Leu Ser Gln Pro Glu 
1505                1510                1515                1520


Ser Asp Glu Glu Gly Tyr Ala Leu Ser Gly Arg Arg Asn Val Asp Leu 
                1525                1530                1535


Asp Leu Ala Ala Ser His Arg Lys Arg Gly Pro Met His Ser Gln Leu 
            1540                1545                1550


Glu Ser Leu Ser Asp Ser Trp Ala Arg Leu Lys His Ser Arg Asp Trp 
        1555                1560                1565


Leu Cys Asn Ser Ser Tyr Ser Phe Glu Ser Asp Phe Asp Leu Thr Lys 
    1570                1575                1580


Ser Leu Gly Val His Thr Leu Ile Glu Asn Val Val Ser Phe Val Ser 
1585                1590                1595                1600


Gly Asp Val Gly Asn Ala Pro Gly Phe Lys Glu Pro Glu Glu Ser Met 
                1605                1610                1615


Ser Thr Ser Pro Gln Ala Ser Ile Ile Ala Met Glu Gln Gln Gln Leu 
            1620                1625                1630


Arg Ala Glu Leu Arg Leu Glu Ala Leu His Gln Ile Leu Val Leu Leu 
        1635                1640                1645


Ser Gly Met Glu Glu Lys Gly Ser Ile Ser Leu Ala Gly Ser Arg Leu 
    1650                1655                1660


Ser Ser Gly Phe Gln Ser Ser Thr Leu Leu Thr Ser Val Arg Leu Gln 
1665                1670                1675                1680


Phe Leu Ala Gly Cys Phe Gly Leu Gly Thr Val Gly His Thr Gly Gly 
                1685                1690                1695


Lys Gly Glu Ser Gly Arg Leu His His Tyr Gln Asp Gly Ile Arg Ala 
            1700                1705                1710


Ala Lys Arg Asn Ile Gln Ile Glu Ile Gln Val Ala Val His Lys Ile 
        1715                1720                1725


Tyr Gln Gln Leu Ser Ala Thr Leu Glu Arg Ala Leu Gln Ala Asn Lys 
    1730                1735                1740


His His Ile Glu Ala Gln Gln Arg Leu Leu Leu Val Thr Val Phe Ala 
1745                1750                1755                1760


Leu Ser Val His Tyr Gln Pro Val Asp Val Ser Leu Ala Ile Ser Thr 
                1765                1770                1775


Gly Leu Leu Asn Val Leu Ser Gln Leu Cys Gly Thr Asp Thr Met Leu 
            1780                1785                1790


Gly Gln Pro Leu Gln Leu Leu Pro Lys Thr Gly Val Ser Gln Leu Ser 
        1795                1800                1805


Thr Ala Leu Lys Val Ala Ser Thr Arg Leu Leu Gln Ile Leu Ala Ile 
    1810                1815                1820


Thr Thr Gly Thr Tyr Ala Asp Lys Leu Ser Pro Lys Val Val Gln Ser 
1825                1830                1835                1840


Leu Leu Asp Leu Leu Cys Ser Gln Leu Lys Asn Leu Leu Ser Gln Thr 
                1845                1850                1855


Gly Val Leu His Met Ala Ser Phe Gly Glu Gly Glu Gln Glu Asp Gly 
            1860                1865                1870


Glu Glu Glu Glu Lys Lys Val Asp Ser Ser Gly Glu Thr Glu Lys Lys 
        1875                1880                1885


Asp Phe Arg Ala Ala Leu Arg Lys Gln His Ala Ala Glu Leu His Leu 
    1890                1895                1900


Gly Asp Phe Leu Val Phe Leu Arg Arg Val Val Ser Ser Lys Ala Ile 
1905                1910                1915                1920


Gln Ser Lys Met Ala Ser Pro Lys Trp Thr Glu Val Leu Leu Asn Ile 
                1925                1930                1935


Ala Ser Gln Lys Cys Ser Ser Gly Ile Pro Leu Val Gly Asn Leu Arg 
            1940                1945                1950


Thr Arg Leu Leu Ala Leu His Val Leu Glu Ala Val Leu Pro Ala Cys 
        1955                1960                1965


Glu Ser Gly Val Glu Asp Asp Gln Met Ala Gln Ile Val Glu Arg Leu 
    1970                1975                1980


Phe Ser Leu Leu Ser Asp Cys Met Trp Glu Thr Pro Ile Ala Gln Ala 
1985                1990                1995                2000


Lys His Ala Ile Gln Ile Lys Glu Lys Glu Gln Glu Ile Lys Leu Gln 
                2005                2010                2015


Lys Gln Gly Glu Leu Glu Glu Glu Asp Glu Asn Leu Pro Ile Gln Glu 
            2020                2025                2030


Val Ser Phe Asp Pro Glu Lys Ala Gln Cys Cys Leu Val Glu Asn Gly 
        2035                2040                2045


Gln Ile Leu Thr His Gly Ser Gly Gly Lys Gly Tyr Gly Leu Ala Ser 
    2050                2055                2060


Thr Gly Val Thr Ser Gly Cys Tyr Gln Trp Lys Phe Tyr Ile Val Lys 
2065                2070                2075                2080


Glu Asn Arg Gly Asn Glu Gly Thr Cys Val Gly Val Ser Arg Trp Pro 
                2085                2090                2095


Val His Asp Phe Asn His Arg Thr Thr Ser Asp Met Trp Leu Tyr Arg 
            2100                2105                2110


Ala Tyr Ser Gly Asn Leu Tyr His Asn Gly Glu Gln Thr Leu Thr Leu 
        2115                2120                2125


Ser Ser Phe Thr Gln Gly Asp Phe Ile Thr Cys Val Leu Asp Met Glu 
    2130                2135                2140


Ala Arg Thr Ile Ser Phe Gly Lys Asn Gly Glu Glu Pro Lys Leu Ala 
2145                2150                2155                2160


Phe Glu Asp Val Asp Ala Ala Glu Leu Tyr Pro Cys Val Met Phe Tyr 
                2165                2170                2175


Ser Ser Asn Pro Gly Glu Lys Val Lys Ile Cys Asp Met Gln Met Arg 
            2180                2185                2190


Gly Thr Pro Arg Asp Leu Leu Pro Gly Asp Pro Ile Cys Ser Pro Val 
        2195                2200                2205


Ala Ala Val Leu Ala Glu Ala Thr Ile Gln Leu Ile Arg Ile Leu His 
    2210                2215                2220


Arg Thr Asp Arg Trp Thr Tyr Cys Ile Asn Lys Lys Met Met Glu Arg 
2225                2230                2235                2240


Leu His Lys Ile Lys Ile Cys Ile Lys Glu Ser Gly Gln Lys Leu Lys 
                2245                2250                2255


Lys Ser Arg Ser Val Gln Ser Arg Glu Glu Asn Glu Met Arg Glu Glu 
            2260                2265                2270


Lys Glu Ser Lys Glu Glu Glu Lys Gly Lys His Thr Arg His Gly Leu 
        2275                2280                2285


Ala Asp Leu Ser Glu Leu Gln Leu Arg Thr Leu Cys Ile Glu Val Trp 
    2290                2295                2300


Pro Val Leu Ala Val Ile Gly Gly Val Asp Ala Gly Leu Arg Val Gly 
2305                2310                2315                2320


Gly Arg Cys Val His Lys Gln Thr Gly Arg His Ala Thr Leu Leu Gly 
                2325                2330                2335


Val Val Lys Glu Gly Ser Thr Ser Ala Lys Val Gln Trp Asp Glu Ala 
            2340                2345                2350


Glu Ile Thr Ile Ser Phe Pro Thr Phe Trp Ser Pro Ser Asp Thr Pro 
        2355                2360                2365


Leu Tyr Asn Leu Glu Pro Cys Glu Pro Leu Pro Phe Asp Val Ala Arg 
    2370                2375                2380


Phe Arg Gly Leu Thr Ala Ser Val Leu Leu Asp Leu Thr Tyr Leu Thr 
2385                2390                2395                2400


Gly Val His Glu Asp Met Gly Lys Gln Ser Thr Lys Arg His Glu Lys 
                2405                2410                2415


Lys His Arg His Glu Ser Glu Glu Lys Gly Asp Val Glu Gln Lys Pro 
            2420                2425                2430


Glu Ser Glu Ser Ala Leu Asp Met Arg Thr Gly Leu Thr Ser Asp Asp 
        2435                2440                2445


Val Lys Ser Gln Ser Thr Thr Ser Ser Lys Ser Glu Asn Glu Ile Ala 
    2450                2455                2460


Ser Phe Ser Leu Asp Pro Thr Leu Pro Ser Val Glu Ser Gln His Gln 
2465                2470                2475                2480


Ile Thr Glu Gly Lys Arg Lys Asn His Glu His Met Ser Lys Asn His 
                2485                2490                2495


Asp Val Ala Gln Ser Glu Ile Arg Ala Val Gln Leu Ser Tyr Leu Tyr 
            2500                2505                2510


Leu Gly Ala Met Lys Ser Leu Ser Ala Leu Leu Gly Cys Ser Lys Tyr 
        2515                2520                2525


Ala Glu Leu Leu Leu Ile Pro Lys Val Leu Ala Glu Asn Gly His Asn 
    2530                2535                2540


Ser Asp Cys Ala Ser Ser Pro Val Val His Glu Asp Val Glu Met Arg 
2545                2550                2555                2560


Ala Ala Leu Gln Phe Leu Met Arg His Met Val Lys Arg Ala Val Met 
                2565                2570                2575


Arg Ser Pro Ile Lys Arg Ala Leu Gly Leu Ala Asp Leu Glu Arg Ala 
            2580                2585                2590


Gln Ala Met Ile Tyr Lys Leu Val Val His Gly Leu Leu Glu Asp Gln 
        2595                2600                2605


Phe Gly Gly Lys Ile Lys Gln Glu Ile Asp Gln Gln Ala Glu Glu Ser 
    2610                2615                2620


Asp Pro Ala Gln Gln Ala Gln Thr Pro Val Thr Thr Ser Pro Ser Ala 
2625                2630                2635                2640


Ser Ser Thr Thr Ser Phe Met Ser Ser Ser Leu Glu Asp Thr Thr Thr 
                2645                2650                2655


Ala Thr Thr Pro Val Thr Asp Thr Glu Thr Val Pro Ala Ser Glu Ser 
            2660                2665                2670


Pro Gly Val Met Pro Leu Ser Leu Leu Arg Gln Met Phe Ser Ser Tyr 
        2675                2680                2685


Pro Thr Thr Thr Val Leu Pro Thr Arg Arg Ala Gln Thr Pro Pro Ile 
    2690                2695                2700


Ser Ser Leu Pro Thr Ser Pro Ser Asp Glu Val Gly Arg Arg Gln Ser 
2705                2710                2715                2720


Leu Thr Ser Pro Asp Ser Gln Ser Ala Arg Pro Ala Asn Arg Thr Ala 
                2725                2730                2735


Leu Ser Asp Pro Ser Ser Arg Leu Ser Thr Ser Pro Pro Pro Pro Ala 
            2740                2745                2750


Ile Ala Val Pro Leu Leu Glu Met Gly Phe Ser Leu Arg Gln Ile Ala 
        2755                2760                2765


Lys Ala Met Glu Ala Thr Gly Ala Arg Gly Glu Ala Asp Ala Gln Asn 
    2770                2775                2780


Ile Thr Val Leu Ala Met Trp Met Ile Glu His Pro Gly His Glu Asp 
2785                2790                2795                2800


Glu Glu Glu Pro Gln Ser Gly Ser Thr Ala Asp Ser Arg Pro Gly Ala 
                2805                2810                2815


Ala Val Leu Gly Ser Gly Gly Lys Ser Asn Asp Pro Cys Tyr Leu Gln 
            2820                2825                2830


Ser Pro Gly Asp Ile Pro Ser Ala Asp Ala Ala Glu Met Glu Glu Gly 
        2835                2840                2845


Phe Ser Glu Ser Pro Asp Asn Leu Asp His Thr Glu Asn Ala Ala Ser 
    2850                2855                2860


Gly Ser Gly Pro Ser Ala Arg Gly Arg Ser Ala Val Thr Arg Arg His 
2865                2870                2875                2880


Lys Phe Asp Leu Ala Ala Arg Thr Leu Leu Ala Arg Ala Ala Gly Leu 
                2885                2890                2895


Tyr Arg Ser Val Gln Ala His Arg Asn Gln Ser Arg Arg Glu Gly Ile 
            2900                2905                2910


Ser Leu Gln Gln Asp Pro Gly Ala Leu Tyr Asp Phe Asn Leu Asp Glu 
        2915                2920                2925


Glu Leu Glu Ile Asp Leu Asp Asp Glu Ala Met Glu Ala Met Phe Gly 
    2930                2935                2940


Gln Asp Leu Thr Ser Asp Asn Asp Ile Leu Gly Met Trp Ile Pro Glu 
2945                2950                2955                2960


Val Leu Asp Trp Pro Thr Trp His Val Cys Glu Ser Glu Asp Arg Glu 
                2965                2970                2975


Glu Val Val Val Cys Glu Leu Cys Glu Cys Ser Val Val Ser Phe Asn 
            2980                2985                2990


Gln His Met Lys Arg Asn His Pro Gly Cys Gly Arg Ser Ala Asn Arg 
        2995                3000                3005


Gln Gly Tyr Arg Ser Asn Gly Ser Tyr Val Asp Gly Trp Phe Gly Gly 
    3010                3015                3020


Glu Cys Gly Ser Gly Asn Pro Tyr Tyr Leu Leu Cys Gly Thr Cys Arg 
3025                3030                3035                3040


Glu Lys Tyr Leu Ala Met Lys Thr Lys Ser Lys Ser Thr Ser Ser Glu 
                3045                3050                3055


Arg Tyr Lys Gly Gln Ala Pro Asp Leu Ile Gly Lys Gln Asp Ser Val 
            3060                3065                3070


Tyr Glu Glu Asp Trp Asp Met Leu Asp Val Asp Glu Asp Glu Lys Leu 
        3075                3080                3085


Thr Gly Glu Glu Glu Phe Glu Leu Leu Ala Gly Pro Leu Gly Leu Asn 
    3090                3095                3100


Asp Arg Arg Ile Val Pro Glu Pro Val Gln Phe Pro Asp Ser Asp Pro 
3105                3110                3115                3120


Leu Gly Ala Ser Val Ala Met Val Thr Ala Thr Asn Ser Met Glu Glu 
                3125                3130                3135


Thr Leu Met Gln Ile Gly Cys His Gly Ser Val Glu Lys Ser Ser Ser 
            3140                3145                3150


Gly Arg Ile Thr Leu Gly Glu Gln Ala Ala Ala Leu Ala Asn Pro His 
        3155                3160                3165


Asp Arg Val Val Ala Leu Arg Arg Val Thr Ala Ala Ala Gln Val Leu 
    3170                3175                3180


Leu Ala Arg Thr Met Val Met Arg Ala Leu Ser Leu Leu Ser Val Ser 
3185                3190                3195                3200


Gly Ser Ser Cys Ser Leu Ala Ala Gly Leu Glu Ser Leu Gly Leu Thr 
                3205                3210                3215


Asp Ile Arg Thr Leu Val Arg Leu Met Cys Leu Ala Ala Ala Gly Arg 
            3220                3225                3230


Ala Gly Leu Ser Thr Ser Pro Ser Ala Met Ala Ser Thr Ser Glu Arg 
        3235                3240                3245


Ser Arg Gly Gly His Ser Lys Ala Asn Lys Pro Ile Ser Cys Leu Ala 
    3250                3255                3260


Tyr Leu Ser Thr Ala Val Gly Cys Leu Ala Ser Asn Ala Pro Ser Ala 
3265                3270                3275                3280


Ala Lys Leu Leu Val Gln Leu Cys Thr Gln Asn Leu Ile Ser Ala Ala 
                3285                3290                3295


Thr Gly Val Asn Leu Thr Thr Val Asp Asp Ser Ile Gln Arg Lys Phe 
            3300                3305                3310


Leu Pro Ser Phe Leu Arg Gly Ile Ala Glu Glu Asn Lys Leu Val Thr 
        3315                3320                3325


Ser Pro Asn Phe Val Val Thr Gln Ala Leu Val Ala Leu Leu Ala Asp 
    3330                3335                3340


Lys Gly Ala Lys Leu Arg Pro Asn Tyr Asp Lys Ser Glu Val Glu Lys 
3345                3350                3355                3360


Lys Gly Pro Leu Glu Leu Ala Asn Ala Leu Ala Ala Cys Cys Leu Ser 
                3365                3370                3375


Ser Arg Leu Ser Ser Gln His Arg Gln Trp Ala Ala Gln Gln Leu Val 
            3380                3385                3390


Arg Thr Leu Ala Ala His Asp Arg Asp Asn Gln Thr Thr Leu Gln Thr 
        3395                3400                3405


Leu Ala Asp Met Gly Gly Asp Leu Arg Lys Cys Ser Phe Ile Lys Leu 
    3410                3415                3420


Glu Ala His Gln Asn Arg Val Met Thr Cys Val Trp Cys Asn Lys Lys 
3425                3430                3435                3440


Gly Leu Leu Ala Thr Ser Gly Asn Asp Gly Thr Ile Arg Val Trp Asn 
                3445                3450                3455


Val Thr Lys Lys Gln Tyr Ser Leu Gln Gln Thr Cys Val Phe Asn Arg 
            3460                3465                3470


Leu Glu Gly Asp Ala Glu Glu Ser Leu Gly Ser Pro Ser Asp Pro Ser 
        3475                3480                3485


Phe Ser Pro Val Ser Trp Ser Ile Ser Gly Lys Tyr Leu Ala Gly Ala 
    3490                3495                3500


Leu Glu Lys Met Val Asn Ile Trp Gln Val Asn Gly Gly Lys Gly Leu 
3505                3510                3515                3520


Val Asp Ile Gln Pro His Trp Val Ser Ala Leu Ala Trp Pro Glu Glu 
                3525                3530                3535


Gly Pro Ala Thr Ala Trp Ser Gly Glu Ser Pro Glu Leu Leu Leu Val 
            3540                3545                3550


Gly Arg Met Asp Gly Ser Leu Gly Leu Ile Glu Val Val Asp Val Ser 
        3555                3560                3565


Thr Met His Arg Arg Glu Leu Glu His Cys Tyr Arg Lys Asp Val Ser 
    3570                3575                3580


Val Thr Cys Ile Ala Trp Phe Ser Glu Asp Arg Pro Phe Ala Val Gly 
3585                3590                3595                3600


Tyr Phe Asp Gly Lys Leu Leu Leu Gly Thr Lys Glu Pro Leu Glu Lys 
                3605                3610                3615


Gly Gly Ile Val Leu Ile Asp Ala His Lys Asp Thr Leu Ile Ser Met 
            3620                3625                3630


Lys Trp Asp Pro Thr Gly His Ile Leu Met Thr Cys Ala Lys Glu Asp 
        3635                3640                3645


Ser Val Lys Leu Trp Gly Ser Ile Ser Gly Cys Trp Cys Cys Leu His 
    3650                3655                3660


Ser Leu Cys His Pro Ser Ile Val Asn Gly Ile Ala Trp Cys Arg Leu 
3665                3670                3675                3680


Pro Gly Lys Gly Ser Lys Leu Gln Leu Leu Met Ala Thr Gly Cys Gln 
                3685                3690                3695


Ser Gly Leu Val Cys Val Trp Arg Ile Pro Gln Asp Thr Thr Gln Thr 
            3700                3705                3710


Asn Val Thr Ser Ala Glu Gly Trp Trp Glu Gln Glu Ser Asn Cys Gln 
        3715                3720                3725


Asp Gly Tyr Arg Lys Ser Ser Gly Ala Lys Cys Val Tyr Gln Leu Arg 
    3730                3735                3740


Gly His Ile Thr Pro Val Arg Thr Val Ala Phe Ser Ser Asp Gly Leu 
3745                3750                3755                3760


Ala Leu Val Ser Gly Gly Leu Gly Gly Leu Met Asn Ile Trp Ser Leu 
                3765                3770                3775


Arg Asp Gly Ser Val Leu Gln Thr Val Val Ile Gly Ser Gly Ala Ile 
            3780                3785                3790


Gln Thr Thr Val Trp Ile Pro Glu Val Gly Val Ala Ala Cys Ser Asn 
        3795                3800                3805


Arg Ser Lys Asp Val Leu Val Val Asn Cys Thr Ala Glu Trp Ala Ala 
    3810                3815                3820


Ala Asn His Val Leu Ala Thr Cys Arg Thr Ala Leu Lys Gln Gln Gly 
3825                3830                3835                3840


Val Leu Gly Leu Asn Met Ala Pro Cys Met Arg Ala Phe Leu Glu Arg 
                3845                3850                3855


Leu Pro Met Met Leu Gln Glu Gln Tyr Ala Tyr Glu Lys Pro His Val 
            3860                3865                3870


Val Cys Gly Asp Gln Leu Val His Ser Pro Tyr Met Gln Cys Leu Ala 
        3875                3880                3885


Ser Leu Ala Val Gly Leu His Leu Asp Gln Leu Leu Cys Asn Pro Pro 
    3890                3895                3900


Val Pro Pro His His Gln Asn Cys Leu Pro Asp Pro Ala Ser Trp Asn 
3905                3910                3915                3920


Pro Asn Glu Trp Ala Trp Leu Glu Cys Phe Ser Thr Thr Ile Lys Ala 
                3925                3930                3935


Ala Glu Ala Leu Thr Asn Gly Ala Gln Phe Pro Glu Ser Phe Thr Val 
            3940                3945                3950


Pro Asp Leu Glu Pro Val Pro Glu Asp Glu Leu Val Phe Leu Met Asp 
        3955                3960                3965


Asn Ser Lys Trp Ile Asn Gly Met Asp Glu Gln Ile Met Ser Trp Ala 
    3970                3975                3980


Thr Ser Arg Pro Glu Asp Trp His Leu Gly Gly Lys Cys Asp Val Tyr 
3985                3990                3995                4000


Leu Trp Gly Ala Gly Arg His Gly Gln Leu Ala Glu Ala Gly Arg Asn 
                4005                4010                4015


Val Met Val Pro Ala Ala Ala Pro Ser Phe Ser Gln Ala Gln Gln Val 
            4020                4025                4030


Ile Cys Gly Gln Asn Cys Thr Phe Val Ile Gln Ala Asn Gly Thr Val 
        4035                4040                4045


Leu Ala Cys Gly Glu Gly Ser Tyr Gly Arg Leu Gly Gln Gly Asn Ser 
    4050                4055                4060


Asp Asp Leu His Val Leu Thr Val Ile Ser Ala Leu Gln Gly Phe Val 
4065                4070                4075                4080


Val Thr Gln Leu Val Thr Ser Cys Gly Ser Asp Gly His Ser Met Ala 
                4085                4090                4095


Leu Thr Glu Ser Gly Glu Val Phe Ser Trp Gly Asp Gly Asp Tyr Gly 
            4100                4105                4110


Lys Leu Gly His Gly Asn Ser Asp Arg Gln Arg Arg Pro Arg Gln Ile 
        4115                4120                4125


Glu Ala Leu Gln Gly Glu Glu Val Val Gln Met Ser Cys Gly Phe Lys 
    4130                4135                4140


His Ser Ala Val Val Thr Ser Asp Gly Lys Leu Phe Thr Phe Gly Asn 
4145                4150                4155                4160


Gly Asp Tyr Gly Arg Leu Gly Leu Gly Asn Thr Ser Asn Lys Lys Leu 
                4165                4170                4175


Pro Glu Arg Val Thr Ala Leu Glu Gly Tyr Gln Ile Gly Gln Val Ala 
            4180                4185                4190


Cys Gly Leu Asn His Thr Leu Ala Val Ser Ala Asp Gly Ser Met Val 
        4195                4200                4205


Trp Ala Phe Gly Asp Gly Asp Tyr Gly Lys Leu Gly Leu Gly Asn Ser 
    4210                4215                4220


Thr Ala Lys Ser Ser Pro Gln Lys Ile Asp Val Leu Cys Gly Ile Gly 
4225                4230                4235                4240


Ile Lys Lys Val Ala Cys Gly Thr Gln Phe Ser Val Ala Leu Thr Lys 
                4245                4250                4255


Asp Gly His Val Tyr Thr Phe Gly Gln Asp Arg Leu Ile Gly Leu Pro 
            4260                4265                4270


Glu Gly Arg Ala Arg Asn His Asn Arg Pro Gln Gln Ile Pro Val Leu 
        4275                4280                4285


Ala Gly Val Ile Ile Glu Asp Val Ala Val Gly Ala Glu His Thr Leu 
    4290                4295                4300


Ala Leu Ala Ser Asn Gly Asp Val Tyr Ala Trp Gly Ser Asn Ser Glu 
4305                4310                4315                4320


Gly Gln Leu Gly Leu Gly His Thr Asn His Val Arg Glu Pro Thr Leu 
                4325                4330                4335


Val Thr Gly Leu Gln Gly Lys Asn Val Arg Gln Ile Ser Ala Gly Arg 
            4340                4345                4350


Cys His Ser Ala Ala Trp Thr Ala Pro Pro Val Pro Pro Arg Ala Pro 
        4355                4360                4365


Gly Val Ser Val Pro Leu Gln Leu Gly Leu Pro Asp Thr Val Pro Pro 
    4370                4375                4380


Gln Tyr Gly Ala Leu Arg Glu Val Ser Ile His Thr Val Arg Ala Arg 
4385                4390                4395                4400


Leu Arg Leu Leu Tyr His Phe Ser Asp Leu Met Tyr Ser Ser Trp Arg 
                4405                4410                4415


Leu Leu Asn Leu Ser Pro Asn Asn Gln Asn Ser Thr Ser His Tyr Asn 
            4420                4425                4430


Ala Gly Thr Trp Gly Ile Val Gln Gly Gln Leu Arg Pro Leu Leu Ala 
        4435                4440                4445


Pro Arg Val Tyr Thr Leu Pro Met Val Arg Ser Ile Gly Lys Thr Met 
    4450                4455                4460


Val Gln Gly Lys Asn Tyr Gly Pro Gln Ile Thr Val Lys Arg Ile Ser 
4465                4470                4475                4480


Thr Arg Gly Arg Lys Cys Lys Pro Ile Phe Val Gln Ile Ala Arg Gln 
                4485                4490                4495


Val Val Lys Leu Asn Ala Ser Asp Leu Arg Leu Pro Ser Arg Ala Trp 
            4500                4505                4510


Lys Val Lys Leu Val Gly Glu Gly Ala Asp Asp Ala Gly Gly Val Phe 
        4515                4520                4525


Asp Asp Thr Ile Thr Glu Met Cys Gln Glu Leu Glu Thr Gly Ile Val 
    4530                4535                4540


Asp Leu Leu Ile Pro Ser Pro Asn Ala Thr Ala Glu Val Gly Tyr Asn 
4545                4550                4555                4560


Arg Asp Arg Phe Leu Phe Asn Pro Ser Ala Cys Leu Asp Glu His Leu 
                4565                4570                4575


Met Gln Phe Lys Phe Leu Gly Ile Leu Met Gly Val Ala Ile Arg Thr 
            4580                4585                4590


Lys Lys Pro Leu Asp Leu His Leu Ala Pro Leu Val Trp Lys Gln Leu 
        4595                4600                4605


Cys Cys Val Pro Leu Thr Leu Glu Asp Leu Glu Glu Val Asp Leu Leu 
    4610                4615                4620


Tyr Val Gln Thr Leu Asn Ser Ile Leu His Ile Glu Asp Ser Gly Ile 
4625                4630                4635                4640


Thr Glu Glu Ser Phe His Glu Met Ile Pro Leu Asp Ser Phe Val Gly 
                4645                4650                4655


Gln Ser Ala Asp Gly Lys Met Val Pro Ile Ile Pro Gly Gly Asn Ser 
            4660                4665                4670


Ile Pro Leu Thr Phe Ser Asn Arg Lys Glu Tyr Val Glu Arg Ala Ile 
        4675                4680                4685


Glu Tyr Arg Leu His Glu Met Asp Arg Gln Val Ala Ala Val Arg Glu 
    4690                4695                4700


Gly Met Ser Trp Ile Val Pro Val Pro Leu Leu Ser Leu Leu Thr Ala 
4705                4710                4715                4720


Lys Gln Leu Glu Gln Met Val Cys Gly Met Pro Glu Ile Ser Val Glu 
                4725                4730                4735


Val Leu Lys Lys Val Val Arg Tyr Arg Glu Val Asp Glu Gln His Gln 
            4740                4745                4750


Leu Val Gln Trp Phe Trp His Thr Leu Glu Glu Phe Ser Asn Glu Glu 
        4755                4760                4765


Arg Val Leu Phe Met Arg Phe Val Ser Gly Arg Ser Arg Leu Pro Ala 
    4770                4775                4780


Asn Thr Ala Asp Ile Ser Gln Arg Phe Gln Ile Met Lys Val Asp Arg 
4785                4790                4795                4800


Pro Tyr Asp Ser Leu Pro Thr Ser Gln Thr Cys Phe Phe Gln Leu Arg 
                4805                4810                4815


Leu Pro Pro Tyr Ser Ser Gln Leu Val Met Ala Glu Arg Leu Arg Tyr 
            4820                4825                4830


Ala Ile Asn Asn Cys Arg Ser Ile Asp Met Asp Asn Tyr Met Leu Ser 
        4835                4840                4845


Arg Asn Val Asp Asn Ala Glu Gly Ser Asp Thr Asp Tyr 
    4850                4855                4860


<210>  1054
<211>  2628
<212>  DNA
<213>  Homo sapiens

<400>  1054
gaccgcggca gctcagcctc ccgccgattg tatgttccag gcctcaatga ggagtccaaa     60

catggagcca ttcaagcagc agaaggtgga ggacttttat gacatcggag aggagctggg    120

gagtggccag tttgccatcg tgaagaagtg ccgggagaag agcacggggc ttgagtatgc    180

agccaagttc atcaagaagc ggcagagccg ggcgagccgg cgcggtgtga gccgggagga    240

gatcgagcgg gaggtgagca tcctgcggca ggtgctgcac cacaatgtca tcacgctgca    300

cgacgtctat gagaaccgca ccgacgtggt gctcatcctt gagctagtgt ctggaggaga    360

gctcttcgat ttcctggccc agaaggagtc actgagtgag gaggaggcca ccagcttcat    420

taagcagatc ctggatgggg tgaactacct tcacacaaag aaaattgctc actttgatct    480

caagccagaa aacattatgt tgttagacaa gaatattccc attccacaca tcaagctgat    540

tgactttggt ctggctcacg aaatagaaga tggagttgaa tttaagaata tttttgggac    600

gccggaattt gttgctccag aaattgtgaa ctacgagccc ctgggtctgg aggctgacat    660

gtggagcata ggcgtcatca cctacatcct cttaagtgga gcatcccctt tcctgggaga    720

cacgaagcag gaaacactgg caaatatcac agcagtgagt tacgactttg atgaggaatt    780

cttcagccag acgagcgagc tggccaagga ctttattcgg aagcttctgg ttaaagagac    840

ccggaaacgg ctcacaatcc aagaggctct cagacacccc tggatcacgc cggtggacaa    900

ccagcaagcc atggtgcgca gggagtctgt ggtcaatctg gagaacttca ggaagcagta    960

tgtccgcagg cggtggaagc tttccttcag catcgtgtcc ctgtgcaacc acctcacccg   1020

ctcgctgatg aagaaggtgc acctgaggcc ggatgaggac ctgaggaact gtgagagtga   1080

cactgaggag gacatcgcca ggaggaaagc cctccaccca cggaggagga gcagcacctc   1140

ctaactggcc tgacctgcag tggccgccag ggaggtctgg gcccagcggg gctcccttct   1200

gtgcagactt ttggacccag ctcagcacca gcacccgggc gtcctgagca ctttgcaaga   1260

gagatgggcc caaggaattc agaagagctt gcaggcaagc caggagaccc tgggagctgt   1320

ggctgtcttc tgtggaggag gctccagcat tcccaaagct cttaattctc cataaaatgg   1380

gctttcctct gtctgccatc ctcagagtct ggggtgggag tgtggactta ggaaaacaat   1440

ataaaggaca tcctcatcat cacggggtga aggtcagact aaggcagcct tcttcacagg   1500

ctgagggggt tcagaaccag cctggccaaa aattacacca gagagacaga gtcctcccca   1560

ttgggaacag ggtgattgag gaaagtgaac cttgggtgtg agggaccaat cctgtgacct   1620

cccagaacca tggaagccag gacgtcaggc tgaccaacac ctcagacctt ctgaagcagc   1680

ccattgctgg cccgccatgt tgtaattttg ctcattttta ttaaacttct ggtttacctg   1740

atgcttggct tcttttaggg ctacccccat ctcatttcct ttagcccgtg tgcctgtaac   1800

tctgaggggg ggcacccagt ggggtgctga gtgggcagaa tctcagaagg tcctcctgaa   1860

ccgtccgcgc aggcctgcag tgggcctgcc tcctccttgc ttccctaaca ggaaggtgtc   1920

cagttcaaga gaacccaccc agagactggg agtggtggct cacgcctata atccctgcgc   1980

tttggcagtc cgaggcaggg gaattgcttg aactcaggag ttggagacca gcctgggcaa   2040

catggcaaaa cgcagtctgt acaaaaaata caaaaaatta gccaggtgta ggggtaggca   2100

cctggcatcc cagctactcc aggggctgag gtgacagcat tgcttaagcc cagaaggtcg   2160

aggctgcagt gagctgagat cacgccactg cactccagtc tgggtgacag agagagacca   2220

tatccaaaaa aaaaaaaagt tgccagagac gagtatgccc atgctccctc tacctcactg   2280

ccaccactcc tgctgttagg agctgagtgt gtctccctaa aatttctatg ttgaagtctt   2340

aacccttggt accacagaat atcactgtat ttggagatgg ggtctttaga aaggcactta   2400

aattaaaatg agctcactga tatgggcccc gatgcaatat aattggtgtc cttataagaa   2460

ggggaggtta ggacacgcag gaaagaccac atgaaggccc aggagtggga gggggaatag   2520

ccatcgacaa actaaggggg cctcagagga aaccaaccct gctgacacct caatcttaga   2580

ctctggcctc aaaaattgta agaaaataaa cttctgtctt ttaagcca                2628


<210>  1055
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  1055

Met Phe Gln Ala Ser Met Arg Ser Pro Asn Met Glu Pro Phe Lys Gln 
1               5                   10                  15


Gln Lys Val Glu Asp Phe Tyr Asp Ile Gly Glu Glu Leu Gly Ser Gly 
            20                  25                  30


Gln Phe Ala Ile Val Lys Lys Cys Arg Glu Lys Ser Thr Gly Leu Glu 
        35                  40                  45


Tyr Ala Ala Lys Phe Ile Lys Lys Arg Gln Ser Arg Ala Ser Arg Arg 
    50                  55                  60


Gly Val Ser Arg Glu Glu Ile Glu Arg Glu Val Ser Ile Leu Arg Gln 
65                  70                  75                  80


Val Leu His His Asn Val Ile Thr Leu His Asp Val Tyr Glu Asn Arg 
                85                  90                  95


Thr Asp Val Val Leu Ile Leu Glu Leu Val Ser Gly Gly Glu Leu Phe 
            100                 105                 110


Asp Phe Leu Ala Gln Lys Glu Ser Leu Ser Glu Glu Glu Ala Thr Ser 
        115                 120                 125


Phe Ile Lys Gln Ile Leu Asp Gly Val Asn Tyr Leu His Thr Lys Lys 
    130                 135                 140


Ile Ala His Phe Asp Leu Lys Pro Glu Asn Ile Met Leu Leu Asp Lys 
145                 150                 155                 160


Asn Ile Pro Ile Pro His Ile Lys Leu Ile Asp Phe Gly Leu Ala His 
                165                 170                 175


Glu Ile Glu Asp Gly Val Glu Phe Lys Asn Ile Phe Gly Thr Pro Glu 
            180                 185                 190


Phe Val Ala Pro Glu Ile Val Asn Tyr Glu Pro Leu Gly Leu Glu Ala 
        195                 200                 205


Asp Met Trp Ser Ile Gly Val Ile Thr Tyr Ile Leu Leu Ser Gly Ala 
    210                 215                 220


Ser Pro Phe Leu Gly Asp Thr Lys Gln Glu Thr Leu Ala Asn Ile Thr 
225                 230                 235                 240


Ala Val Ser Tyr Asp Phe Asp Glu Glu Phe Phe Ser Gln Thr Ser Glu 
                245                 250                 255


Leu Ala Lys Asp Phe Ile Arg Lys Leu Leu Val Lys Glu Thr Arg Lys 
            260                 265                 270


Arg Leu Thr Ile Gln Glu Ala Leu Arg His Pro Trp Ile Thr Pro Val 
        275                 280                 285


Asp Asn Gln Gln Ala Met Val Arg Arg Glu Ser Val Val Asn Leu Glu 
    290                 295                 300


Asn Phe Arg Lys Gln Tyr Val Arg Arg Arg Trp Lys Leu Ser Phe Ser 
305                 310                 315                 320


Ile Val Ser Leu Cys Asn His Leu Thr Arg Ser Leu Met Lys Lys Val 
                325                 330                 335


His Leu Arg Pro Asp Glu Asp Leu Arg Asn Cys Glu Ser Asp Thr Glu 
            340                 345                 350


Glu Asp Ile Ala Arg Arg Lys Ala Leu His Pro Arg Arg Arg Ser Ser 
        355                 360                 365


Thr Ser 
    370


<210>  1056
<211>  138
<212>  DNA
<213>  Homo sapiens

<400>  1056
atggagggga acagggatga agctgagaaa tgtgtcgaca tcgtccagga ggctctgaat     60

gctggcaacc gcgagaaggc ccagcgtttc ctgcagaagg ccgagaagct ctacccactg    120

cccttggcct gcgcataa                                                  138


<210>  1057
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  1057

Met Glu Gly Asn Arg Asp Glu Ala Glu Lys Cys Val Asp Ile Val Gln 
1               5                   10                  15


Glu Ala Leu Asn Ala Gly Asn Arg Glu Lys Ala Gln Arg Phe Leu Gln 
            20                  25                  30


Lys Ala Glu Lys Leu Tyr Pro Leu Pro Leu Ala Cys Ala 
        35                  40                  45


<210>  1058
<211>  723
<212>  DNA
<213>  Homo sapiens

<400>  1058
atggtggtaa ccaggaacag ttcccttccc ccaccacaca cccccccaaa aagactagaa     60

aaaaaactgg tcaacttgga cgctggccgc gctcacgcag aacccgtgcc cgcgggccgg    120

ggaaggctga acagaccctg ggaggaaaag tgggcctgca ggcaccccgg gctccccccg    180

ccgcctgtct cagataccga gcaggtggga ttccgggaag ccacctccga cttacgagcc    240

ccccacgcgt ccgacgcaga ggcgcgggtg ctactctcag caccgccgcg ccatcccggg    300

gcggaccgag ccgcggagca cctcccggat ctcaggagct ctcgggcgga gatctcggcc    360

atccgtgcct cctccccgaa cccacccgcc ccgctcccgc gcccccggct gtcacctctc    420

cgggccgtga cagctccacc tgccaccgct gcccgggtcg ccgcccccgc actcaccacc    480

cagctggctc ccgtgcgagc agcggatcga gctcggagag cggcgccgga atcccgcacg    540

cgcggtagcg gaacacgagg ggctgaatgc cgcggcgctc tgagcccgct tagctcatcc    600

ccagcccggc gctccgccct tcgcggcacc cccgcccgcc cgcccaggcc tgccgtctca    660

gtcagacggg actccccctc ccctcgcggc cgccactgcc tccgcctctt tctccgactc    720

tag                                                                  723


<210>  1059
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  1059

Met Val Val Thr Arg Asn Ser Ser Leu Pro Pro Pro His Thr Pro Pro 
1               5                   10                  15


Lys Arg Leu Glu Lys Lys Leu Val Asn Leu Asp Ala Gly Arg Ala His 
            20                  25                  30


Ala Glu Pro Val Pro Ala Gly Arg Gly Arg Leu Asn Arg Pro Trp Glu 
        35                  40                  45


Glu Lys Trp Ala Cys Arg His Pro Gly Leu Pro Pro Pro Pro Val Ser 
    50                  55                  60


Asp Thr Glu Gln Val Gly Phe Arg Glu Ala Thr Ser Asp Leu Arg Ala 
65                  70                  75                  80


Pro His Ala Ser Asp Ala Glu Ala Arg Val Leu Leu Ser Ala Pro Pro 
                85                  90                  95


Arg His Pro Gly Ala Asp Arg Ala Ala Glu His Leu Pro Asp Leu Arg 
            100                 105                 110


Ser Ser Arg Ala Glu Ile Ser Ala Ile Arg Ala Ser Ser Pro Asn Pro 
        115                 120                 125


Pro Ala Pro Leu Pro Arg Pro Arg Leu Ser Pro Leu Arg Ala Val Thr 
    130                 135                 140


Ala Pro Pro Ala Thr Ala Ala Arg Val Ala Ala Pro Ala Leu Thr Thr 
145                 150                 155                 160


Gln Leu Ala Pro Val Arg Ala Ala Asp Arg Ala Arg Arg Ala Ala Pro 
                165                 170                 175


Glu Ser Arg Thr Arg Gly Ser Gly Thr Arg Gly Ala Glu Cys Arg Gly 
            180                 185                 190


Ala Leu Ser Pro Leu Ser Ser Ser Pro Ala Arg Arg Ser Ala Leu Arg 
        195                 200                 205


Gly Thr Pro Ala Arg Pro Pro Arg Pro Ala Val Ser Val Arg Arg Asp 
    210                 215                 220


Ser Pro Ser Pro Arg Gly Arg His Cys Leu Arg Leu Phe Leu Arg Leu 
225                 230                 235                 240


<210>  1060
<211>  2393
<212>  DNA
<213>  Homo sapiens

<400>  1060
agcggcaggg aggggctctt cacccagtcc ggcagttgaa gctcggcgct cgggttaccc     60

ctgcagcgac gccccctggt cccacagata ccactgctgc tcccgccctt tcgctcctcg    120

gccgcgcaat gggcacccgc gacgacgagt acgactacct ctttaaagtt gtccttattg    180

gagattctgg tgttggaaag agtaatctcc tgtctcgatt tactcgaaat gagtttaatc    240

tggaaagcaa gagcaccatt ggagtagagt ttgcaacaag aagcatccag gttgatggaa    300

aaacaataaa ggcacagata tgggacacag cagggcaaga gcgatatcga gctataacat    360

cagcatatta tcgtggagct gtaggtgcct tattggttta tgacattgct aaacatctca    420

catatgaaaa tgtagagcga tggctgaaag aactgagaga tcatgctgat agtaacattg    480

ttatcatgct tgtgggcaat aagagtgatc tacgtcatct cagggcagtt cctacagatg    540

aagcaagagc ttttgcagaa aagaatggtt tgtcattcat tgaaacttcg gccctagact    600

ctacaaatgt agaagctgct tttcagacaa ttttaacaga gatttaccgc attgtttctc    660

agaagcaaat gtcagacaga cgcgaaaatg acatgtctcc aagcaacaat gtggttccta    720

ttcatgttcc accaaccact gaaaacaagc caaaggtgca gtgctgtcag aacatctaag    780

gcatttctct tctcccctag aaggctgtgt atagtccatt tcccaggtct gagatttaaa    840

tatatttgta attcttgtgt cacttttgtg ttttattact tcatacttat gaatttttcc    900

atgtcctaag tcttttgatt ttagctttat aaaatcatcc acttgtcccg aatgactgca    960

gctttttttc atgctatggc ttcactagcc ttagtttaat aaactgaatg tttggattcc   1020

tcagttattg tttacttttc atcatggaag cctgtcactg tatgtaggac ataatagaac   1080

ttgatcactt gaagctcaga cctattggtc ttgatcaaat caaactaaga agaccttaga   1140

aataagctac cattttgcca cagagcagct tataggtaat acactcttct ctcagtgcag   1200

tgtacatttc cacaaatcta agaattgccc tataaacata gcaggatttt gagagcttga   1260

aaattttcca ttattctgga catgaatttc taaaatgcct taataggttt atgtagttga   1320

gtaaattttg ttttttaatt tttgtaagca tcaaagttga ttagagaggg gggcactttt   1380

tctggagaat tctcttagta aacacaaaag attgttacgg tttcattagt agtatggttg   1440

tggggccata agttaaacag tgctgcctgg taggctggga actgaagaga cttgtggtat   1500

tccatctcgg gtgcctctgt tggcaatgat caggcagccc aaaagattta aatgatctat   1560

aataatttcc aagcggtaga ttatgtggca ttttattgct caggcaataa ttggtttaat   1620

gctggtagtg tcaaattttg aagtgttaat tttgtcttag aaccttccag taagtgaaat   1680

acaacctagt tttatcacca tatccaccag caggcatgga taattatttt aacaatgcta   1740

atatttgagt tttgcagtat attatagaat atagtccagt taaatctttg gtttcagtat   1800

gtctgaagag tacagtgaga ggttaatttc tgctcaagtg gtaccactta aaggcatgta   1860

ttcttttagt atgtaaaatg aaatagtacc ttgagtttaa atagaatgca tttaggcatt   1920

gtagagatct gaaatagttt tcttccacta cattgttgaa atcaatgaag caattagttt   1980

ctcattcaga aatgtgcaca ctaatattta gttttgcttt ctcgtggata atattaagca   2040

cttactctgc agtttcctgg aagttgtgtc aactgcagtg atactattca ggatggtggg   2100

aaatccccaa aaatatgtat gtgtgggctt gcttagatta ctatatttca tagttaatct   2160

tttgtctctt gcggtgctca tgatgtgtgg ggcacacgga aggcattgct gtagtcagtc   2220

attttggttt tcttctatag ccattttatt attttagtgt attagttatg aagataatat   2280

tatctatttg taaattgcta ctttgtattt tatgcatgct ctgtaatttg attttttttt   2340

agttattgat ttggattata ttcacattct aataaacagt tataggggga tta          2393


<210>  1061
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  1061

Met Gly Thr Arg Asp Asp Glu Tyr Asp Tyr Leu Phe Lys Val Val Leu 
1               5                   10                  15


Ile Gly Asp Ser Gly Val Gly Lys Ser Asn Leu Leu Ser Arg Phe Thr 
            20                  25                  30


Arg Asn Glu Phe Asn Leu Glu Ser Lys Ser Thr Ile Gly Val Glu Phe 
        35                  40                  45


Ala Thr Arg Ser Ile Gln Val Asp Gly Lys Thr Ile Lys Ala Gln Ile 
    50                  55                  60


Trp Asp Thr Ala Gly Gln Glu Arg Tyr Arg Ala Ile Thr Ser Ala Tyr 
65                  70                  75                  80


Tyr Arg Gly Ala Val Gly Ala Leu Leu Val Tyr Asp Ile Ala Lys His 
                85                  90                  95


Leu Thr Tyr Glu Asn Val Glu Arg Trp Leu Lys Glu Leu Arg Asp His 
            100                 105                 110


Ala Asp Ser Asn Ile Val Ile Met Leu Val Gly Asn Lys Ser Asp Leu 
        115                 120                 125


Arg His Leu Arg Ala Val Pro Thr Asp Glu Ala Arg Ala Phe Ala Glu 
    130                 135                 140


Lys Asn Gly Leu Ser Phe Ile Glu Thr Ser Ala Leu Asp Ser Thr Asn 
145                 150                 155                 160


Val Glu Ala Ala Phe Gln Thr Ile Leu Thr Glu Ile Tyr Arg Ile Val 
                165                 170                 175


Ser Gln Lys Gln Met Ser Asp Arg Arg Glu Asn Asp Met Ser Pro Ser 
            180                 185                 190


Asn Asn Val Val Pro Ile His Val Pro Pro Thr Thr Glu Asn Lys Pro 
        195                 200                 205


Lys Val Gln Cys Cys Gln Asn Ile 
    210                 215


<210>  1062
<211>  3997
<212>  DNA
<213>  Homo sapiens

<400>  1062
gatcgccgag ccggccacca tgcccggcag accgcgccac taggcgctcc tcgcggctcc     60

cacccggcgg cggcggcggc ggcggcggcg tccgcgatgg tttcagacgc tgaaggattt    120

tgcatctgat cgctcggcgt ttcaaagaag cagcgatcgg agatggatgt ctctctttgc    180

ccagccaagt gtagtttctg gcggattttc ttgctgggaa gcgtctggct ggactatgtg    240

ggctccgtgc tggcttgccc tgcaaattgt gtctgcagca agactgagat caattgccgg    300

cggccggacg atgggaacct cttccccctc ctggaagggc aggattcagg gaacagcaat    360

gggaacgcca gtatcaacat cacggacatc tcaaggaata tcacttccat acacatagag    420

aactggcgca gtcttcacac gctcaacgcc gtggacatgg agctctacac cggacttcaa    480

aagctgacca tcaagaactc aggacttcgg agcattcagc ccagagcctt tgccaagaac    540

ccccatttgc gttatataaa cctgtcaagt aaccggctca ccacactctc gtggcagctc    600

ttccagacgc tgagtcttcg ggaattgcag ttggagcaga actttttcaa ctgcagctgt    660

gacatccgct ggatgcagct ctggcaggag cagggggagg ccaagctcaa cagccagaac    720

ctctactgca tcaacgctga tggctcccag cttcctctct tccgcatgaa catcagtcag    780

tgtgaccttc ctgagatcag cgtgagccac gtcaacctga ccgtacgaga gggtgacaat    840

gctgttatca cttgcaatgg ctctggatca ccccttcctg atgtggactg gatagtcact    900

gggctgcagt ccatcaacac tcaccagacc aatctgaact ggaccaatgt tcatgccatc    960

aacttgacgc tggtgaatgt gacgagtgag gacaatggct tcaccctgac gtgcattgca   1020

gagaacgtgg tgggcatgag caatgccagt gttgccctca ctgtctacta tcccccacgt   1080

gtggtgagcc tggaggagcc tgagctgcgc ctggagcact gcatcgagtt tgtggtgcgt   1140

ggcaaccccc caccaacgct gcactggctg cacaatgggc agcctctgcg ggagtccaag   1200

atcatccatg tggaatacta ccaagaggga gagatttccg agggctgcct gctcttcaac   1260

aagcccaccc actacaacaa tggcaactat accctcattg ccaaaaaccc actgggcaca   1320

gccaaccaga ccatcaatgg ccacttcctc aaggagccct ttccagagag cacggataac   1380

tttatcttgt ttgacgaagt gagtcccaca cctcctatca ctgtgaccca caaaccagaa   1440

gaagacactt ttggggtatc catagcagtt ggacttgctg cttttgcctg tgtcctgttg   1500

gtggttctct tcgtcatgat caacaaatat ggtcgacggt ccaaatttgg aatgaagggt   1560

cccgtggctg tcatcagtgg tgaggaggac tcagccagcc cactgcacca catcaaccac   1620

ggcatcacca cgccctcgtc actggatgcc gggcccgaca ctgtggtcat tggcatgact   1680

cgcatccctg tcattgagaa cccccagtac ttccgtcagg gacacaactg ccacaagccg   1740

gacacgtggg tcttttcaaa catagacaat catgggatat taaacttgaa ggacaataga   1800

gatcatctag tcccatcaac tcactatata tatgaggaac ctgaggtcca gagtggggaa   1860

gtgtcttacc caaggtcaca tggtttcaga gaaattatgt tgaatccaat aagccttccc   1920

ggacattcca agcctcttaa ccatggcatc tatgttgagg atgtcaatgt ttatttcagc   1980

aaaggacgtc atggctttta aaaactcctt ttaagcctcc ttgttttgat gtcaccttgg   2040

taggctgggc cctctgagag gttggaagct ctaggcattg ttctctttgg atccagggat   2100

gctaagtaga aactgcatga gccaccagtg ccccggcacc ctttaacacc accagatggg   2160

tgttttcccc catccaccac tggcagggtt gccccttccc tccaatcatc actgtgctcc   2220

ttttttcccg gcctacgagg cagctcctgc cactatcttt agagccaata aagagaatta   2280

aaaacctgtg caccaggagc atcttttaaa tacactagcc attctcttgc tttacaaaaa   2340

caacctaacc atcacaagaa agcctgatga agtccagccg tgctccagcc tcactttccc   2400

tgcttggaag cgtggggtct ccctggctct cccaggatac catgctgtcc tcttagtgac   2460

ctcgtcgccc tgcaacctcc agtggggaag agtcacagag agcacctaag cagaggtgga   2520

gacggcgcgg taagaggagg gggagccagg ctcaagtatt ggcaccaagt taggtctcag   2580

aggaaagaat ggaaaccaat cactttacat ttttattttt attttcggtg gaaaaatcat   2640

ccttttttgg gacatacttg ccccctactt cctcttctct ctggaacggc tcacaatgag   2700

tgtgacatta gaaaactcct tgcagaggag agtttctcca ggctcttcct gggcccttag   2760

atctgcagtt ccgacaagct ttggctgcag gaggttttac ccatgaactg gccatcctac   2820

taggaccaca agggaccaag ggaatcaggg acaaaggccc ttcctgccag cccatgatcc   2880

cgggattggc tctcttcccc tacttccact tattcttgac tctgagaact tttggaaccc   2940

aatggaatca gcatttcaag gtcaagatga actgaagggg aagagaagta aaacttggcc   3000

tcctccagcc cctctcatgg caccaatgga agtgtcctcc tgttctctgg tcaatatgtg   3060

tgtttacttt gcttgctttg actcatgcct tactccatgg ccaccctctc ccaaagaggg   3120

ggctcgcttc ccccattttc aacttgatcc actgaggaga gggaaggggg tgactttccc   3180

ttcttcagta ggaaaggcac atttgtaggg cctgaaactc tcccgtattt gctgactcat   3240

tggtggagta gacttctggc tcccagctcc actggcccat ggggcctcca ttgtatgaag   3300

tcagcatagg ctgcccacct aatggtggag agcatgaaac tgggagcatc ctgtgggggg   3360

cttgtggggg aaaaaggtgg ttgttttaac ccaccgttgt tttggggtgg tgttgcacac   3420

tagtagagaa tagagtctat gcctttggca aatttaactg ggagtttgga ttcccactta   3480

agggttttac ttcttgggtc ctgtggatgg tggttcttcg tgtcaggatc ccagcccgat   3540

tctgcaaatg cctccatggg gtttaaaaac atgaggcttt ccaagttctt gcccagtatc   3600

tggggcagcc tccagagtat cacctgggag ttcaggttct ctccagggct ccaggtgtgt   3660

gtttatctcg ccccctccag ctctcctcat cctgctcccc attgctccat gtcaggctgt   3720

tccccattgt gccctgctga tgctttgggt ccagggcctc ctcccaagtg tggctttaag   3780

gagtaagctt gaggatgatg ttttttaatt attgtaaatc attacctcat ttccagcctc   3840

ccaggctcca tccatcccag catcttttat tctgccattt tcctcacctt gtgctatgac   3900

aatggggcgt tgtgtttcca cagagactta taggagtgtt cagtgtatag tttcttaata   3960

aacactttat tttctaatga aaaaaaaaaa aaaaaaa                            3997


<210>  1063
<211>  612
<212>  PRT
<213>  Homo sapiens

<400>  1063

Met Asp Val Ser Leu Cys Pro Ala Lys Cys Ser Phe Trp Arg Ile Phe 
1               5                   10                  15


Leu Leu Gly Ser Val Trp Leu Asp Tyr Val Gly Ser Val Leu Ala Cys 
            20                  25                  30


Pro Ala Asn Cys Val Cys Ser Lys Thr Glu Ile Asn Cys Arg Arg Pro 
        35                  40                  45


Asp Asp Gly Asn Leu Phe Pro Leu Leu Glu Gly Gln Asp Ser Gly Asn 
    50                  55                  60


Ser Asn Gly Asn Ala Ser Ile Asn Ile Thr Asp Ile Ser Arg Asn Ile 
65                  70                  75                  80


Thr Ser Ile His Ile Glu Asn Trp Arg Ser Leu His Thr Leu Asn Ala 
                85                  90                  95


Val Asp Met Glu Leu Tyr Thr Gly Leu Gln Lys Leu Thr Ile Lys Asn 
            100                 105                 110


Ser Gly Leu Arg Ser Ile Gln Pro Arg Ala Phe Ala Lys Asn Pro His 
        115                 120                 125


Leu Arg Tyr Ile Asn Leu Ser Ser Asn Arg Leu Thr Thr Leu Ser Trp 
    130                 135                 140


Gln Leu Phe Gln Thr Leu Ser Leu Arg Glu Leu Gln Leu Glu Gln Asn 
145                 150                 155                 160


Phe Phe Asn Cys Ser Cys Asp Ile Arg Trp Met Gln Leu Trp Gln Glu 
                165                 170                 175


Gln Gly Glu Ala Lys Leu Asn Ser Gln Asn Leu Tyr Cys Ile Asn Ala 
            180                 185                 190


Asp Gly Ser Gln Leu Pro Leu Phe Arg Met Asn Ile Ser Gln Cys Asp 
        195                 200                 205


Leu Pro Glu Ile Ser Val Ser His Val Asn Leu Thr Val Arg Glu Gly 
    210                 215                 220


Asp Asn Ala Val Ile Thr Cys Asn Gly Ser Gly Ser Pro Leu Pro Asp 
225                 230                 235                 240


Val Asp Trp Ile Val Thr Gly Leu Gln Ser Ile Asn Thr His Gln Thr 
                245                 250                 255


Asn Leu Asn Trp Thr Asn Val His Ala Ile Asn Leu Thr Leu Val Asn 
            260                 265                 270


Val Thr Ser Glu Asp Asn Gly Phe Thr Leu Thr Cys Ile Ala Glu Asn 
        275                 280                 285


Val Val Gly Met Ser Asn Ala Ser Val Ala Leu Thr Val Tyr Tyr Pro 
    290                 295                 300


Pro Arg Val Val Ser Leu Glu Glu Pro Glu Leu Arg Leu Glu His Cys 
305                 310                 315                 320


Ile Glu Phe Val Val Arg Gly Asn Pro Pro Pro Thr Leu His Trp Leu 
                325                 330                 335


His Asn Gly Gln Pro Leu Arg Glu Ser Lys Ile Ile His Val Glu Tyr 
            340                 345                 350


Tyr Gln Glu Gly Glu Ile Ser Glu Gly Cys Leu Leu Phe Asn Lys Pro 
        355                 360                 365


Thr His Tyr Asn Asn Gly Asn Tyr Thr Leu Ile Ala Lys Asn Pro Leu 
    370                 375                 380


Gly Thr Ala Asn Gln Thr Ile Asn Gly His Phe Leu Lys Glu Pro Phe 
385                 390                 395                 400


Pro Glu Ser Thr Asp Asn Phe Ile Leu Phe Asp Glu Val Ser Pro Thr 
                405                 410                 415


Pro Pro Ile Thr Val Thr His Lys Pro Glu Glu Asp Thr Phe Gly Val 
            420                 425                 430


Ser Ile Ala Val Gly Leu Ala Ala Phe Ala Cys Val Leu Leu Val Val 
        435                 440                 445


Leu Phe Val Met Ile Asn Lys Tyr Gly Arg Arg Ser Lys Phe Gly Met 
    450                 455                 460


Lys Gly Pro Val Ala Val Ile Ser Gly Glu Glu Asp Ser Ala Ser Pro 
465                 470                 475                 480


Leu His His Ile Asn His Gly Ile Thr Thr Pro Ser Ser Leu Asp Ala 
                485                 490                 495


Gly Pro Asp Thr Val Val Ile Gly Met Thr Arg Ile Pro Val Ile Glu 
            500                 505                 510


Asn Pro Gln Tyr Phe Arg Gln Gly His Asn Cys His Lys Pro Asp Thr 
        515                 520                 525


Trp Val Phe Ser Asn Ile Asp Asn His Gly Ile Leu Asn Leu Lys Asp 
    530                 535                 540


Asn Arg Asp His Leu Val Pro Ser Thr His Tyr Ile Tyr Glu Glu Pro 
545                 550                 555                 560


Glu Val Gln Ser Gly Glu Val Ser Tyr Pro Arg Ser His Gly Phe Arg 
                565                 570                 575


Glu Ile Met Leu Asn Pro Ile Ser Leu Pro Gly His Ser Lys Pro Leu 
            580                 585                 590


Asn His Gly Ile Tyr Val Glu Asp Val Asn Val Tyr Phe Ser Lys Gly 
        595                 600                 605


Arg His Gly Phe 
    610


<210>  1064
<211>  2860
<212>  DNA
<213>  Homo sapiens

<400>  1064
gatcgccgag ccggccacca tgcccggcag accgcgccac taggcgctcc tcgcggctcc     60

cacccggcgg cggcggcggc ggcggcggcg tccgcgatgg tttcagacgc tgaaggattt    120

tgcatctgat cgctcggcgt ttcaaagaag cagcgatcgg agatggatgt ctctctttgc    180

ccagccaagt gtagtttctg gcggattttc ttgctgggaa gcgtctggct ggactatgtg    240

ggctccgtgc tggcttgccc tgcaaattgt gtctgcagca agactgagat caattgccgg    300

cggccggacg atgggaacct cttccccctc ctggaagggc aggattcagg gaacagcaat    360

gggaacgcca gtatcaacat cacggacatc tcaaggaata tcacttccat acacatagag    420

aactggcgca gtcttcacac gctcaacgcc gtggacatgg agctctacac cggacttcaa    480

aagctgacca tcaagaactc aggacttcgg agcattcagc ccagagcctt tgccaagaac    540

ccccatttgc gttatataaa cctgtcaagt aaccggctca ccacactctc gtggcagctc    600

ttccagacgc tgagtcttcg ggaattgcag ttggagcaga actttttcaa ctgcagctgt    660

gacatccgct ggatgcagct ctggcaggag cagggggagg ccaagctcaa cagccagaac    720

ctctactgca tcaacgctga tggctcccag cttcctctct tccgcatgaa catcagtcag    780

tgtgaccttc ctgagatcag cgtgagccac gtcaacctga ccgtacgaga gggtgacaat    840

gctgttatca cttgcaatgg ctctggatca ccccttcctg atgtggactg gatagtcact    900

gggctgcagt ccatcaacac tcaccagacc aatctgaact ggaccaatgt tcatgccatc    960

aacttgacgc tggtgaatgt gacgagtgag gacaatggct tcaccctgac gtgcattgca   1020

gagaacgtgg tgggcatgag caatgccagt gttgccctca ctgtctacta tcccccacgt   1080

gtggtgagcc tggaggagcc tgagctgcgc ctggagcact gcatcgagtt tgtggtgcgt   1140

ggcaaccccc caccaacgct gcactggctg cacaatgggc agcctctgcg ggagtccaag   1200

atcatccatg tggaatacta ccaagaggga gagatttccg agggctgcct gctcttcaac   1260

aagcccaccc actacaacaa tggcaactat accctcattg ccaaaaaccc actgggcaca   1320

gccaaccaga ccatcaatgg ccacttcctc aaggagccct ttccagagag cacggataac   1380

tttatcttgt ttgacgaagt gagtcccaca cctcctatca ctgtgaccca caaaccagaa   1440

gaagacactt ttggggtatc catagcagtt ggacttgctg cttttgcctg tgtcctgttg   1500

gtggttctct tcgtcatgat caacaaatat ggtcgacggt ccaaatttgg aatgaagggt   1560

cccgtggctg tcatcagtgg tgaggaggac tcagccagcc cactgcacca catcaaccac   1620

ggcatcacca cgccctcgtc actggatgcc gggcccgaca ctgtggtcat tggcatgact   1680

cgcatccctg tcattgagaa cccccagtac ttccgtcagg gacacaactg ccacaagccg   1740

gacacgtatg tgcagcacat taagaggaga gacatcgtgc tgaagcgaga actgggtgag   1800

ggagcctttg gaaaggtctt cctggccgag tgctacaacc tcagcccgac caaggacaag   1860

atgcttgtgg ctgtgaaggc cctgaaggat cccaccctgg ctgcccggaa ggatttccag   1920

agggaggccg agctgctcac caacctgcag catgagcaca ttgtcaagtt ctatggagtg   1980

tgcggcgatg gggaccccct catcatggtc tttgaataca tgaagcatgg agacctgaat   2040

aagttcctca gggcccatgg gccagatgca atgatccttg tggatggaca gccacgccag   2100

gccaagggtg agctggggct ctcccaaatg ctccacattg ccagtcagat cgcctcgggt   2160

atggtgtacc tggcctccca gcactttgtg caccgagacc tggccaccag gaactgcctg   2220

gttggagcga atctgctagt gaagattggg gacttcggca tgtccagaga tgtctacagc   2280

acggattatt acaggctctt taatccatct ggaaatgatt tttgtatatg gtgtgaggtg   2340

ggaggacaca ccatgctccc cattcgctgg atgcctcctg aaagcatcat gtaccggaag   2400

ttcactacag agagtgatgt atggagcttc ggggtgatcc tctgggagat cttcacctat   2460

ggaaagcagc catggttcca actctcaaac acggaggtca ttgagtgcat tacccaaggt   2520

cgtgttttgg agcggccccg agtctgcccc aaagaggtgt acgatgtcat gctggggtgc   2580

tggcagaggg aaccacagca gcggttgaac atcaaggaga tctacaaaat cctccatgct   2640

ttggggaagg ccaccccaat ctacctggac attcttggct agtggtggct ggtggtcatg   2700

aattcatact ctgttgcctc ctctctccct gcctcacatc tcccttccac ctcacaactc   2760

cttccatcct tgactgaagc gaacatcttc atataaactc aagtgcctgc tacacataca   2820

acactgaaaa aaggaaaaaa aaagaaagaa aaaaaaaccc                         2860


<210>  1065
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  1065

Met Asp Val Ser Leu Cys Pro Ala Lys Cys Ser Phe Trp Arg Ile Phe 
1               5                   10                  15


Leu Leu Gly Ser Val Trp Leu Asp Tyr Val Gly Ser Val Leu Ala Cys 
            20                  25                  30


Pro Ala Asn Cys Val Cys Ser Lys Thr Glu Ile Asn Cys Arg Arg Pro 
        35                  40                  45


Asp Asp Gly Asn Leu Phe Pro Leu Leu Glu Gly Gln Asp Ser Gly Asn 
    50                  55                  60


Ser Asn Gly Asn Ala Ser Ile Asn Ile Thr Asp Ile Ser Arg Asn Ile 
65                  70                  75                  80


Thr Ser Ile His Ile Glu Asn Trp Arg Ser Leu His Thr Leu Asn Ala 
                85                  90                  95


Val Asp Met Glu Leu Tyr Thr Gly Leu Gln Lys Leu Thr Ile Lys Asn 
            100                 105                 110


Ser Gly Leu Arg Ser Ile Gln Pro Arg Ala Phe Ala Lys Asn Pro His 
        115                 120                 125


Leu Arg Tyr Ile Asn Leu Ser Ser Asn Arg Leu Thr Thr Leu Ser Trp 
    130                 135                 140


Gln Leu Phe Gln Thr Leu Ser Leu Arg Glu Leu Gln Leu Glu Gln Asn 
145                 150                 155                 160


Phe Phe Asn Cys Ser Cys Asp Ile Arg Trp Met Gln Leu Trp Gln Glu 
                165                 170                 175


Gln Gly Glu Ala Lys Leu Asn Ser Gln Asn Leu Tyr Cys Ile Asn Ala 
            180                 185                 190


Asp Gly Ser Gln Leu Pro Leu Phe Arg Met Asn Ile Ser Gln Cys Asp 
        195                 200                 205


Leu Pro Glu Ile Ser Val Ser His Val Asn Leu Thr Val Arg Glu Gly 
    210                 215                 220


Asp Asn Ala Val Ile Thr Cys Asn Gly Ser Gly Ser Pro Leu Pro Asp 
225                 230                 235                 240


Val Asp Trp Ile Val Thr Gly Leu Gln Ser Ile Asn Thr His Gln Thr 
                245                 250                 255


Asn Leu Asn Trp Thr Asn Val His Ala Ile Asn Leu Thr Leu Val Asn 
            260                 265                 270


Val Thr Ser Glu Asp Asn Gly Phe Thr Leu Thr Cys Ile Ala Glu Asn 
        275                 280                 285


Val Val Gly Met Ser Asn Ala Ser Val Ala Leu Thr Val Tyr Tyr Pro 
    290                 295                 300


Pro Arg Val Val Ser Leu Glu Glu Pro Glu Leu Arg Leu Glu His Cys 
305                 310                 315                 320


Ile Glu Phe Val Val Arg Gly Asn Pro Pro Pro Thr Leu His Trp Leu 
                325                 330                 335


His Asn Gly Gln Pro Leu Arg Glu Ser Lys Ile Ile His Val Glu Tyr 
            340                 345                 350


Tyr Gln Glu Gly Glu Ile Ser Glu Gly Cys Leu Leu Phe Asn Lys Pro 
        355                 360                 365


Thr His Tyr Asn Asn Gly Asn Tyr Thr Leu Ile Ala Lys Asn Pro Leu 
    370                 375                 380


Gly Thr Ala Asn Gln Thr Ile Asn Gly His Phe Leu Lys Glu Pro Phe 
385                 390                 395                 400


Pro Glu Ser Thr Asp Asn Phe Ile Leu Phe Asp Glu Val Ser Pro Thr 
                405                 410                 415


Pro Pro Ile Thr Val Thr His Lys Pro Glu Glu Asp Thr Phe Gly Val 
            420                 425                 430


Ser Ile Ala Val Gly Leu Ala Ala Phe Ala Cys Val Leu Leu Val Val 
        435                 440                 445


Leu Phe Val Met Ile Asn Lys Tyr Gly Arg Arg Ser Lys Phe Gly Met 
    450                 455                 460


Lys Gly Pro Val Ala Val Ile Ser Gly Glu Glu Asp Ser Ala Ser Pro 
465                 470                 475                 480


Leu His His Ile Asn His Gly Ile Thr Thr Pro Ser Ser Leu Asp Ala 
                485                 490                 495


Gly Pro Asp Thr Val Val Ile Gly Met Thr Arg Ile Pro Val Ile Glu 
            500                 505                 510


Asn Pro Gln Tyr Phe Arg Gln Gly His Asn Cys His Lys Pro Asp Thr 
        515                 520                 525


Tyr Val Gln His Ile Lys Arg Arg Asp Ile Val Leu Lys Arg Glu Leu 
    530                 535                 540


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu 
545                 550                 555                 560


Ser Pro Thr Lys Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Asp 
                565                 570                 575


Pro Thr Leu Ala Ala Arg Lys Asp Phe Gln Arg Glu Ala Glu Leu Leu 
            580                 585                 590


Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Gly 
        595                 600                 605


Asp Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp 
    610                 615                 620


Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Met Ile Leu Val 
625                 630                 635                 640


Asp Gly Gln Pro Arg Gln Ala Lys Gly Glu Leu Gly Leu Ser Gln Met 
                645                 650                 655


Leu His Ile Ala Ser Gln Ile Ala Ser Gly Met Val Tyr Leu Ala Ser 
            660                 665                 670


Gln His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly 
        675                 680                 685


Ala Asn Leu Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val 
    690                 695                 700


Tyr Ser Thr Asp Tyr Tyr Arg Leu Phe Asn Pro Ser Gly Asn Asp Phe 
705                 710                 715                 720


Cys Ile Trp Cys Glu Val Gly Gly His Thr Met Leu Pro Ile Arg Trp 
                725                 730                 735


Met Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp 
            740                 745                 750


Val Trp Ser Phe Gly Val Ile Leu Trp Glu Ile Phe Thr Tyr Gly Lys 
        755                 760                 765


Gln Pro Trp Phe Gln Leu Ser Asn Thr Glu Val Ile Glu Cys Ile Thr 
    770                 775                 780


Gln Gly Arg Val Leu Glu Arg Pro Arg Val Cys Pro Lys Glu Val Tyr 
785                 790                 795                 800


Asp Val Met Leu Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg Leu Asn 
                805                 810                 815


Ile Lys Glu Ile Tyr Lys Ile Leu His Ala Leu Gly Lys Ala Thr Pro 
            820                 825                 830


Ile Tyr Leu Asp Ile Leu Gly 
        835


<210>  1066
<211>  2818
<212>  DNA
<213>  Homo sapiens

<400>  1066
gatcgccgag ccggccacca tgcccggcag accgcgccac taggcgctcc tcgcggctcc     60

cacccggcgg cggcggcggc ggcggcggcg tccgcgatgg tttcagacgc tgaaggattt    120

tgcatctgat cgctcggcgt ttcaaagaag cagcgatcgg agatggatgt ctctctttgc    180

ccagccaagt gtagtttctg gcggattttc ttgctgggaa gcgtctggct ggactatgtg    240

ggctccgtgc tggcttgccc tgcaaattgt gtctgcagca agactgagat caattgccgg    300

cggccggacg atgggaacct cttccccctc ctggaagggc aggattcagg gaacagcaat    360

gggaacgcca gtatcaacat cacggacatc tcaaggaata tcacttccat acacatagag    420

aactggcgca gtcttcacac gctcaacgcc gtggacatgg agctctacac cggacttcaa    480

aagctgacca tcaagaactc aggacttcgg agcattcagc ccagagcctt tgccaagaac    540

ccccatttgc gttatataaa cctgtcaagt aaccggctca ccacactctc gtggcagctc    600

ttccagacgc tgagtcttcg ggaattgcag ttggagcaga actttttcaa ctgcagctgt    660

gacatccgct ggatgcagct ctggcaggag cagggggagg ccaagctcaa cagccagaac    720

ctctactgca tcaacgctga tggctcccag cttcctctct tccgcatgaa catcagtcag    780

tgtgaccttc ctgagatcag cgtgagccac gtcaacctga ccgtacgaga gggtgacaat    840

gctgttatca cttgcaatgg ctctggatca ccccttcctg atgtggactg gatagtcact    900

gggctgcagt ccatcaacac tcaccagacc aatctgaact ggaccaatgt tcatgccatc    960

aacttgacgc tggtgaatgt gacgagtgag gacaatggct tcaccctgac gtgcattgca   1020

gagaacgtgg tgggcatgag caatgccagt gttgccctca ctgtctacta tcccccacgt   1080

gtggtgagcc tggaggagcc tgagctgcgc ctggagcact gcatcgagtt tgtggtgcgt   1140

ggcaaccccc caccaacgct gcactggctg cacaatgggc agcctctgcg ggagtccaag   1200

atcatccatg tggaatacta ccaagaggga gagatttccg agggctgcct gctcttcaac   1260

aagcccaccc actacaacaa tggcaactat accctcattg ccaaaaaccc actgggcaca   1320

gccaaccaga ccatcaatgg ccacttcctc aaggagccct ttccagagag cacggataac   1380

tttatcttgt ttgacgaagt gagtcccaca cctcctatca ctgtgaccca caaaccagaa   1440

gaagacactt ttggggtatc catagcagtt ggacttgctg cttttgcctg tgtcctgttg   1500

gtggttctct tcgtcatgat caacaaatat ggtcgacggt ccaaatttgg aatgaagggt   1560

cccgtggctg tcatcagtgg tgaggaggac tcagccagcc cactgcacca catcaaccac   1620

ggcatcacca cgccctcgtc actggatgcc gggcccgaca ctgtggtcat tggcatgact   1680

cgcatccctg tcattgagaa cccccagtac ttccgtcagg gacacaactg ccacaagccg   1740

gacacgtatg tgcagcacat taagaggaga gacatcgtgc tgaagcgaga actgggtgag   1800

ggagcctttg gaaaggtctt cctggccgag tgctacaacc tcagcccgac caaggacaag   1860

atgcttgtgg ctgtgaaggc cctgaaggat cccaccctgg ctgcccggaa ggatttccag   1920

agggaggccg agctgctcac caacctgcag catgagcaca ttgtcaagtt ctatggagtg   1980

tgcggcgatg gggaccccct catcatggtc tttgaataca tgaagcatgg agacctgaat   2040

aagttcctca gggcccatgg gccagatgca atgatccttg tggatggaca gccacgccag   2100

gccaagggtg agctggggct ctcccaaatg ctccacattg ccagtcagat cgcctcgggt   2160

atggtgtacc tggcctccca gcactttgtg caccgagacc tggccaccag gaactgcctg   2220

gttggagcga atctgctagt gaagattggg gacttcggca tgtccagaga tgtctacagc   2280

acggattatt acagggtggg aggacacacc atgctcccca ttcgctggat gcctcctgaa   2340

agcatcatgt accggaagtt cactacagag agtgatgtat ggagcttcgg ggtgatcctc   2400

tgggagatct tcacctatgg aaagcagcca tggttccaac tctcaaacac ggaggtcatt   2460

gagtgcatta cccaaggtcg tgttttggag cggccccgag tctgccccaa agaggtgtac   2520

gatgtcatgc tggggtgctg gcagagggaa ccacagcagc ggttgaacat caaggagatc   2580

tacaaaatcc tccatgcttt ggggaaggcc accccaatct acctggacat tcttggctag   2640

tggtggctgg tggtcatgaa ttcatactct gttgcctcct ctctccctgc ctcacatctc   2700

ccttccacct cacaactcct tccatccttg actgaagcga acatcttcat ataaactcaa   2760

gtgcctgcta cacatacaac actgaaaaaa ggaaaaaaaa agaaagaaaa aaaaaccc     2818


<210>  1067
<211>  825
<212>  PRT
<213>  Homo sapiens

<400>  1067

Met Asp Val Ser Leu Cys Pro Ala Lys Cys Ser Phe Trp Arg Ile Phe 
1               5                   10                  15


Leu Leu Gly Ser Val Trp Leu Asp Tyr Val Gly Ser Val Leu Ala Cys 
            20                  25                  30


Pro Ala Asn Cys Val Cys Ser Lys Thr Glu Ile Asn Cys Arg Arg Pro 
        35                  40                  45


Asp Asp Gly Asn Leu Phe Pro Leu Leu Glu Gly Gln Asp Ser Gly Asn 
    50                  55                  60


Ser Asn Gly Asn Ala Ser Ile Asn Ile Thr Asp Ile Ser Arg Asn Ile 
65                  70                  75                  80


Thr Ser Ile His Ile Glu Asn Trp Arg Ser Leu His Thr Leu Asn Ala 
                85                  90                  95


Val Asp Met Glu Leu Tyr Thr Gly Leu Gln Lys Leu Thr Ile Lys Asn 
            100                 105                 110


Ser Gly Leu Arg Ser Ile Gln Pro Arg Ala Phe Ala Lys Asn Pro His 
        115                 120                 125


Leu Arg Tyr Ile Asn Leu Ser Ser Asn Arg Leu Thr Thr Leu Ser Trp 
    130                 135                 140


Gln Leu Phe Gln Thr Leu Ser Leu Arg Glu Leu Gln Leu Glu Gln Asn 
145                 150                 155                 160


Phe Phe Asn Cys Ser Cys Asp Ile Arg Trp Met Gln Leu Trp Gln Glu 
                165                 170                 175


Gln Gly Glu Ala Lys Leu Asn Ser Gln Asn Leu Tyr Cys Ile Asn Ala 
            180                 185                 190


Asp Gly Ser Gln Leu Pro Leu Phe Arg Met Asn Ile Ser Gln Cys Asp 
        195                 200                 205


Leu Pro Glu Ile Ser Val Ser His Val Asn Leu Thr Val Arg Glu Gly 
    210                 215                 220


Asp Asn Ala Val Ile Thr Cys Asn Gly Ser Gly Ser Pro Leu Pro Asp 
225                 230                 235                 240


Val Asp Trp Ile Val Thr Gly Leu Gln Ser Ile Asn Thr His Gln Thr 
                245                 250                 255


Asn Leu Asn Trp Thr Asn Val His Ala Ile Asn Leu Thr Leu Val Asn 
            260                 265                 270


Val Thr Ser Glu Asp Asn Gly Phe Thr Leu Thr Cys Ile Ala Glu Asn 
        275                 280                 285


Val Val Gly Met Ser Asn Ala Ser Val Ala Leu Thr Val Tyr Tyr Pro 
    290                 295                 300


Pro Arg Val Val Ser Leu Glu Glu Pro Glu Leu Arg Leu Glu His Cys 
305                 310                 315                 320


Ile Glu Phe Val Val Arg Gly Asn Pro Pro Pro Thr Leu His Trp Leu 
                325                 330                 335


His Asn Gly Gln Pro Leu Arg Glu Ser Lys Ile Ile His Val Glu Tyr 
            340                 345                 350


Tyr Gln Glu Gly Glu Ile Ser Glu Gly Cys Leu Leu Phe Asn Lys Pro 
        355                 360                 365


Thr His Tyr Asn Asn Gly Asn Tyr Thr Leu Ile Ala Lys Asn Pro Leu 
    370                 375                 380


Gly Thr Ala Asn Gln Thr Ile Asn Gly His Phe Leu Lys Glu Pro Phe 
385                 390                 395                 400


Pro Glu Ser Thr Asp Asn Phe Ile Leu Phe Asp Glu Val Ser Pro Thr 
                405                 410                 415


Pro Pro Ile Thr Val Thr His Lys Pro Glu Glu Asp Thr Phe Gly Val 
            420                 425                 430


Ser Ile Ala Val Gly Leu Ala Ala Phe Ala Cys Val Leu Leu Val Val 
        435                 440                 445


Leu Phe Val Met Ile Asn Lys Tyr Gly Arg Arg Ser Lys Phe Gly Met 
    450                 455                 460


Lys Gly Pro Val Ala Val Ile Ser Gly Glu Glu Asp Ser Ala Ser Pro 
465                 470                 475                 480


Leu His His Ile Asn His Gly Ile Thr Thr Pro Ser Ser Leu Asp Ala 
                485                 490                 495


Gly Pro Asp Thr Val Val Ile Gly Met Thr Arg Ile Pro Val Ile Glu 
            500                 505                 510


Asn Pro Gln Tyr Phe Arg Gln Gly His Asn Cys His Lys Pro Asp Thr 
        515                 520                 525


Tyr Val Gln His Ile Lys Arg Arg Asp Ile Val Leu Lys Arg Glu Leu 
    530                 535                 540


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu 
545                 550                 555                 560


Ser Pro Thr Lys Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Asp 
                565                 570                 575


Pro Thr Leu Ala Ala Arg Lys Asp Phe Gln Arg Glu Ala Glu Leu Leu 
            580                 585                 590


Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Gly 
        595                 600                 605


Asp Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp 
    610                 615                 620


Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Met Ile Leu Val 
625                 630                 635                 640


Asp Gly Gln Pro Arg Gln Ala Lys Gly Glu Leu Gly Leu Ser Gln Met 
                645                 650                 655


Leu His Ile Ala Ser Gln Ile Ala Ser Gly Met Val Tyr Leu Ala Ser 
            660                 665                 670


Gln His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly 
        675                 680                 685


Ala Asn Leu Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val 
    690                 695                 700


Tyr Ser Thr Asp Tyr Tyr Arg Val Gly Gly His Thr Met Leu Pro Ile 
705                 710                 715                 720


Arg Trp Met Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu 
                725                 730                 735


Ser Asp Val Trp Ser Phe Gly Val Ile Leu Trp Glu Ile Phe Thr Tyr 
            740                 745                 750


Gly Lys Gln Pro Trp Phe Gln Leu Ser Asn Thr Glu Val Ile Glu Cys 
        755                 760                 765


Ile Thr Gln Gly Arg Val Leu Glu Arg Pro Arg Val Cys Pro Lys Glu 
    770                 775                 780


Val Tyr Asp Val Met Leu Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg 
785                 790                 795                 800


Leu Asn Ile Lys Glu Ile Tyr Lys Ile Leu His Ala Leu Gly Lys Ala 
                805                 810                 815


Thr Pro Ile Tyr Leu Asp Ile Leu Gly 
            820                 825


<210>  1068
<211>  9085
<212>  DNA
<213>  Homo sapiens

<400>  1068
agtagcgtct gggtccctgg actaaagccg tcaaatgtaa ccaattgctg aggagctctc     60

ccctaagaat cccgcctcca ctctgaggaa cagcttcgct gatcaatgga tcccctccta    120

gacgcaatga gcgcgcgggg caagtggaga agcggctgaa ctgcccaatg aacaagcggt    180

ttccgtggtt aggggcgtgg cagaagcggt cgtcaggggc gtggcggcag ttacttgggc    240

ggggccggta gcggcgggag ctgcactggc caggggttcc ggctgtatat ccatgagcgc    300

cgctggcagc cggggagctg caggaaccag actgggggcg agctgagcac ctgtagtcaa    360

tcacacgcag aaataataat gatacttatg ttagaagatt gttttgagaa gtgcatggag    420

ttactacatc tgaagcattt agaacagtac ctggcacagg gttctgtcct cttcatttgc    480

aagccactgc tttatccacg agggtgctcc ctacttatgc cagtgaatta atttttggca    540

cagatgaatc cttcatattt atctggattt agctggtagc atttgtctcc taagacttgg    600

tcacagagga atccatgtga ccttcaggcc ttctgctcta aactggcagg agatcctgtt    660

tctactcaca gcgtccgagg gtctggtggc cgagccctga ggggcgctgt tgctcccagg    720

tggcagaatt cagcatcaga gagccacaca gctgaaagag atggatggct tttaggtttg    780

tttgaataag agatctgacc tgaccggccc aactgtacaa ctcttcaagg aaaattcgta    840

tttgcagtgg gaagaataag taacattgat caagatgaat gccatgctgg agactcccga    900

actcccagcc gtgtttgatg gagtgaagct ggctgcagtg gctgctgtgc tgtacgtgat    960

cgtccggtgt ttgaacctga agagccccac agccccacct gacctctact tccaggactc   1020

ggggctctca cgctttctgc tcaagtcctg tcctcttctg accaaagaat acattccacc   1080

gttgatctgg gggaaaagtg gacacatcca gacagccttg tatgggaaga tgggaagggt   1140

gaggtcgcca catccttatg ggcaccggaa gttcatcact atgtctgatg gagccacttc   1200

tacattcgac ctcttcgagc ccttggctga gcactgtgtt ggagatgata tcaccatggt   1260

catctgccct ggaattgcca atcacagcga gaagcaatac atccgcactt tcgttgacta   1320

cgcccagaaa aatggctatc ggtgcgccgt gctgaaccac ctgggtgccc tgcccaacat   1380

tgaattgacc tcgccacgca tgttcaccta tggctgcacg tgggaatttg gagccatggt   1440

gaactacatc aagaagacat atcccctgac ccagctggtc gtcgtgggct tcagcctggg   1500

tggtaacatt gtgtgcaaat acttggggga gactcaggca aaccaagaga aggtcctgtg   1560

ctgcgtcagc gtgtgccagg ggtacagtgc actgagggcc caggaaacct tcatgcaatg   1620

ggatcagtgc cggcggttct acaacttcct catggctgac aacatgaaga agatcatcct   1680

ctcgcacagg caagctcttt ttggagacca tgttaagaaa ccccagagcc tggaagacac   1740

ggacttgagc cggctctaca cagcaacatc cctgatgcag attgatgaca atgtgatgag   1800

gaagtttcac ggctataact ccctgaagga atactatgag gaagaaagtt gcatgcggta   1860

cctgcacagg atttatgttc ctctcatgct ggttaatgca gctgacgatc cgttggtgca   1920

tgaaagtctt ctaaccattc caaaatctct ttcagagaaa cgagagaacg tcatgtttgt   1980

gctgcctctg catgggggcc acttgggctt ctttgagggc tctgtgctgt tccccgagcc   2040

cctgacatgg atggataagc tggtggtgga gtacgccaac gccatttgcc aatgggagcg   2100

taacaagttg cagtgctctg acacggagca ggtggaggcc gacctggagt gaggcctccg   2160

gactctggca cgctccagca gccctcctct ggaagctgcg tcccctcacc ccctgtttca   2220

ggtctcccat ctccctcagt gacctggatc tgacctcaca ccatcagcag ggggcaccca   2280

ccatgcacac ctgtctcgga gtaggcagct cttcctggga gctccaggct atttttgtgc   2340

ttagttactg gttttctcca ttgcattgtt aggcatggtg acaagtgaca gagttcttgc   2400

cctctgtcca gtttcagcat ctggttgctt ttaagccaag tacatctagt ttccctatta   2460

aaaatgtgtc tgaatagcga ttttgctttg ccaccaaaag gcttttccct gagaacagtg   2520

aaggatgtat gtcattttgt ggtggttgta tgtgtcctta catagacctt aaaaagagct   2580

cacccttcca ggccaatgct gaagacacag ctccgcttgg gagcctgaga acccaggctt   2640

cccaggccag agtgtggctt cttaaacggc aaaggaaatt cctttgagtc acaagccaag   2700

ttttcgccct gtctcctgag accatttccc tacgctttgc tgctgctgag agttacgtga   2760

ggcacttgtt aaaaattcag cctcccaggt ccctcccctc ggagaggctg attcactggg   2820

tctgggaagg agcctgggga ttttaatttt tcacaagtgc cccagatgat tctcatcacc   2880

aagcaaattt tggaaatgct gttcaacagc gcccttaaat tggaaacatc tttgcagctc   2940

gttttattga aattcataat caggggtgtc ctctagctcc cacggtctcc agagcagcaa   3000

ggccggctat ggagctgccg tcgtgtgacc acagtgtgat gtctcagaag ggctctgggt   3060

gggctgagca tctgggctgt gccctggctc tgcttttcac cctggacaaa gtcgctgtgg   3120

acttcaattt cttcacctct aaaatggggg acttggacca ggtagattgc tgagctcact   3180

accaggttca aagttcaatg acaaactcag tttactgagg tttgagagaa catccctcca   3240

ggggagcctg ggagctgctc tcccagtcta agcatgtaga tatcatcgtt tgccttttgt   3300

gtgtgtgtgt cccttatttg ataaaaagat gttttgagtt gttttttttt taagcactca   3360

cttgtaattt tagtttttaa acccaagtcc ctctaacttt gcctttgata ccaaacaatt   3420

caaaagttgg atctgagttt ggagaaagat atttccaacc taagtgggta ttattttgaa   3480

accagatttt taatttaata gcctatattt gtagtctgtt ggataggtgt ttccaaagtg   3540

tgtcttctca agtgaaaacg caactctagg tttcaagtac tccttttctc cgatcctgtg   3600

gtacttgaat atccaaaaac cctgcacttt gaacaatcag ctgttgctat ctggaactaa   3660

acagaactat gagtaaaatt gcctggatac tttaaaaaga tatttttcct ccttcatctc   3720

ctttgactcc aggacagact ggaatataag tagtgggtct gcatggatgt ttcagggatc   3780

aaaggagcca cctgggcgcc tgagtgccaa ccctcagggc cacaggtggg tgtggtttgg   3840

gcacgggtcc aagtgactgt gacgggaccc gtgggcatgg gtccaggtct gtaacctgaa   3900

gaagttgttt tctgacaatc accaaatcat ccgaatgaca tcaaaagcag cccttatctc   3960

agagactgag atttctgtgg tctcaacttc gctttggtat aatttctggc actcaccagc   4020

ctctatcatt atgactttcc ccccagtgta ttatttctct aataggtttc cttttcacgt   4080

tcttttagca cagactggca ctttaccctc tcagtttgga agttagcccc tctcctctgt   4140

tacttttccc ttcacccaac tacagctgtg atctagaaca ttcatagtca tatttctgct   4200

actactacct tcatttatca agacttttta tgagaatagg taaaccaagc aataacttcc   4260

taggactgaa tcaccacccc agaagagcga gaggctcctt tcatatgcct gaggccacac   4320

cccttaacct gttctgacaa aatagtggct ggcccatgta ccagctccat tcagaaattc   4380

aggaagagaa aagacagccc tgttgtcaca caaaccggtg tgggggaggg tggagcctgg   4440

tctgcacggc agtcctggtg gcccctgtgg aggacaggca gggctggcag catagccttt   4500

gttgccacac aaccggaatt tgctccccca ggactgtggg agccagtgtc ccagctgaaa   4560

tctttttagt gtgtggctct gaatggcact cacattccat tttggctcac atgaaactaa   4620

ctgaagccct ttgttcaagc ttcaggctct taggcatgga aatgagaatg tgactgtggc   4680

tgtcttacag gaaaattctt gtttgtccct gaatgagagc acagaggcat tgaattcaca   4740

gagctgcaaa cttgcctgat aaatgaggga gtggcagttt atagataggt catctttttt   4800

ccttcctcca ggtgtccttg cctttcttcc caaagtcatt catttctgat gagtatatga   4860

atccccctct tgctagtaag gttctatttg ggctaaaaca aggctgaatt tttaaagagt   4920

atttgaatat attttagaat caaattgagg ctataaattg catcaatctg gacaattcca   4980

ttgcaggaat aatatgttaa aaaccaatgg ggagaagcac ccacatctct cctgtagcac   5040

tccgtgtctc ataagcaatt tgaagacact tacaagtaac tgattccagt caaattagga   5100

ttaactgact caaaaaatgg tgtcaagttt ctttaatgtt tttatgttag aagtgagttt   5160

aacagacttg aagaaaactg ttatcttttc ctgctgtgag tttacacaaa tgattccaga   5220

gcagaatgaa agcagaaagc tgttggttac aatattcttt taacctctct gcagcatttt   5280

acacttactg ggaaccttat gattcaccgt aagagtggaa atatacctga gttcgtgtcc   5340

taatggtctc taattcacat tggatcgtgg gcaaatcacc tcacctctct gagcctgttc   5400

cctcctctta gaccatctct aagaccactt catctattta cacatcattt gcttgaacat   5460

tgctgaacat ctgcgtgaac ttggcctctc cagcccttgc aggtggaaac agctgtgtca   5520

aggctcaagg ctcacgctga ggggacttgg agggaggggg cttctgcatt aagctttcct   5580

ggtgaagacc cttgatcttg tccaaagccc tgtgtctttg actggcttct cttcagagtc   5640

cccgttgtca tcgtaagacc cttgctgttt ggagggtggt cttgtgactg tggcagctgc   5700

tggccgctgg aatgaggagc ctatctccat cctccagtgt gactcaggca gagcattgag   5760

aattcccagg gcagaaatcc ttcctgctca ggctttcatt ctaaaactac agtcttcatt   5820

aaagctgaac tttctgggta gctgagctta tatgcccggc atctgaatga gagctctctt   5880

tgtaactgtg tgacttgaga tctagtttgc cagctcctgg gaaacaatac atgtgttctt   5940

gtttgtgttt gctcagcaag cagatgtctg agatgtaaga agcttttctt ttcctgtggc   6000

attgattctg acttagagct gaagtaaaag atcactgaaa catcacgtca agttgaagtc   6060

actcataggt ctttgtcctt taggcaggac aggagagtca ttaagaagca tttcactgta   6120

gcattctatc acaatatcat ctggaattgt tttctttgcc cagaaagcct taacttgcct   6180

ctagagaatc cctggtatta caacgatatt gcggcattag aattccaact cttctgctgt   6240

ggaagtttga agcgaagctg cagcaaaacc agagaatttc ctcaagtggc ctgtaggctc   6300

cttgttatct tatgccccca cccctccctc aacaatatga gtgatccaga actggcccaa   6360

acacctcagc tctggtccct ttttgccctt cttggcctta ctctgttgtt caaagccact   6420

ttggattgct tggatgcttc gaacagccat gaaaagtagc ctgcctgtgg catttagagg   6480

ccaagcaatt gacagaaagg gtttcttcta cctctgttat ctaagcagag ggaagtaaac   6540

ctctcaccgc cccccacccc tcactgcccc cgattaccct agaattgctt tcgccaaatt   6600

gtagttgaag ctaaggaagg ggaatctggc ccctgctggg agagggaact ggaatgccac   6660

acaaggcaag gcctgcttcc ttccttcccc tctgctgctg ctgcctcgga acgctgcagc   6720

ccaggcttcc tcccacagtg gcccttggaa gcaggccgca gagtagacag ctgctccttt   6780

tggaagagtc agtcccctgt gttttctgaa ctgtttttcc tagcatgtat gtgggtagag   6840

ctttcatgca tctctagtaa taataagctg aaattagttt tttttttaat tctccaattt   6900

aaaactttta attaaaaagt aaattttaat gtcgaaaatg caaacttggg gagggcagaa   6960

agatcacaca caaggctgtc acttcatact tgcaggattg cacagcagcc gggcagaggc   7020

gctcctcact tcccagatgg ggcggcgggc agcagagacg cacctcactt cctagacagt   7080

gcggcagcca ggcacaggca cacctcactt cccagacagt tgggcggcca ggcaagcgct   7140

cctcacttcc cagatggggc ggctcccggg aagcggggct cctcacttcc cagacagggt   7200

ggccaggcag aggtgctcct cacttcccag aacaattctt tatgaatttg ataaaggact   7260

gaagtgcaac tgaaagctgc tagtgatgat ctggtaatat acaatttgtc cagtagccag   7320

tttgttttta ttgtgttttc taaccataag agatcattaa aggcaaagcc tgtatgacgc   7380

tgtacacaca caaaaaaatg gtcaccgcag gccatactac caatgaaatg gtaggtaaac   7440

aaatcttctg gtcaagagaa aaaaaaaaga aatagcactc tgcatgcttt gctctacaag   7500

acgaatttcc ctagaaagaa tccaatgaag gccgggcata gtggctcact cctgtaatcc   7560

cagcactttg gaggccgagg cgggtagatc acctgaggtt aggagttcaa gaccagcctg   7620

gccaacatgg tgaaacccct tctctactaa aaatgcaaaa attagctggg tgtggtggcg   7680

ggcgcctgta atcccagcta ctcgggaggc tgaggtggga gaattgcttg aacccaggag   7740

acggaggttg cagtgagccg agatcacgcc tctgcactcc agcctgggca acaagagtga   7800

gactccgtct ccaaaaaaag aaaaggaatc cagtgaaaat ggctgcaatt acaacaagaa   7860

gtgaaggaag aagactggtg acatctctga aggatgcagt tgaggttgat ccaggtttat   7920

ccgaatatgc tacctttctg agccttaaac cttcatctct caggtgttga tttgcttctg   7980

atagcttcat catttctccc tgaagtcttt tacactcttc tgttagtttc cttgtttcag   8040

tatcatgaag tgaagcactg tgtggttgtg gcgtgggccc gtcttgctta gatgcattca   8100

gtgggacagc tttgctgggt tccatgtcat tcaatttatc attttcattg gggatctcca   8160

tttggaatcc attaattcat gaggttttgc ctcattccac acagcttcca tatctgaagt   8220

gtttagtgga gcaaaaattg taccataaac ttgtgtttac tcttttcatt cggatcatag   8280

tcaaagggct gtagcattac tgaaacagtc acagttgacc ctgggtcaat aattccactg   8340

ttgggcctca cacagtaccg gtgaggcacg gtagtcttca ctttgaaaca cacttttcta   8400

tccgatggat ttcgcaattt aagatttgta gtgactacat ctgtgaaggg gcctttgaat   8460

ttgaggtcta tgggcgggtc gaggaccagg atctgctcgt gcttcgccgt ggccccggag   8520

gcagacgcca ttggagagac agcgcagagc agggggcggc ttgctcgctg ggggcggggg   8580

acgatggcga gaggggaggg ggagcgagtt cgcatctctc cttttcctgg ttagactctg   8640

ttcaaccaca ttcttatgtt ggcagatctg cttccagatt gatttttaga gcaccatcac   8700

tttcacattc ctgattctga ttttgttttg ttttgtttgg gttttctgaa acttaaaatg   8760

ctgccccgaa aatactatat ttttgagttt gtgttctgaa agcctccgtg ctgctggatc   8820

tttgggggga aatacaggat ccttcagcac tgaggtgttt aagatttgca actagcaatg   8880

caattttttc taaatatggg gatatttacc tttattaaga aattatacta aacattgatg   8940

tccttgatca ttttatgttc tcatattact tttgattcta ctatgattgt gtggtggtga   9000

acaaagatca ttacaaacaa aaactgtaat tttgttatat ttgattcaat ggaatttacc   9060

taaaaaataa agactaaaaa tgtgg                                         9085


<210>  1069
<211>  425
<212>  PRT
<213>  Homo sapiens

<400>  1069

Met Asn Ala Met Leu Glu Thr Pro Glu Leu Pro Ala Val Phe Asp Gly 
1               5                   10                  15


Val Lys Leu Ala Ala Val Ala Ala Val Leu Tyr Val Ile Val Arg Cys 
            20                  25                  30


Leu Asn Leu Lys Ser Pro Thr Ala Pro Pro Asp Leu Tyr Phe Gln Asp 
        35                  40                  45


Ser Gly Leu Ser Arg Phe Leu Leu Lys Ser Cys Pro Leu Leu Thr Lys 
    50                  55                  60


Glu Tyr Ile Pro Pro Leu Ile Trp Gly Lys Ser Gly His Ile Gln Thr 
65                  70                  75                  80


Ala Leu Tyr Gly Lys Met Gly Arg Val Arg Ser Pro His Pro Tyr Gly 
                85                  90                  95


His Arg Lys Phe Ile Thr Met Ser Asp Gly Ala Thr Ser Thr Phe Asp 
            100                 105                 110


Leu Phe Glu Pro Leu Ala Glu His Cys Val Gly Asp Asp Ile Thr Met 
        115                 120                 125


Val Ile Cys Pro Gly Ile Ala Asn His Ser Glu Lys Gln Tyr Ile Arg 
    130                 135                 140


Thr Phe Val Asp Tyr Ala Gln Lys Asn Gly Tyr Arg Cys Ala Val Leu 
145                 150                 155                 160


Asn His Leu Gly Ala Leu Pro Asn Ile Glu Leu Thr Ser Pro Arg Met 
                165                 170                 175


Phe Thr Tyr Gly Cys Thr Trp Glu Phe Gly Ala Met Val Asn Tyr Ile 
            180                 185                 190


Lys Lys Thr Tyr Pro Leu Thr Gln Leu Val Val Val Gly Phe Ser Leu 
        195                 200                 205


Gly Gly Asn Ile Val Cys Lys Tyr Leu Gly Glu Thr Gln Ala Asn Gln 
    210                 215                 220


Glu Lys Val Leu Cys Cys Val Ser Val Cys Gln Gly Tyr Ser Ala Leu 
225                 230                 235                 240


Arg Ala Gln Glu Thr Phe Met Gln Trp Asp Gln Cys Arg Arg Phe Tyr 
                245                 250                 255


Asn Phe Leu Met Ala Asp Asn Met Lys Lys Ile Ile Leu Ser His Arg 
            260                 265                 270


Gln Ala Leu Phe Gly Asp His Val Lys Lys Pro Gln Ser Leu Glu Asp 
        275                 280                 285


Thr Asp Leu Ser Arg Leu Tyr Thr Ala Thr Ser Leu Met Gln Ile Asp 
    290                 295                 300


Asp Asn Val Met Arg Lys Phe His Gly Tyr Asn Ser Leu Lys Glu Tyr 
305                 310                 315                 320


Tyr Glu Glu Glu Ser Cys Met Arg Tyr Leu His Arg Ile Tyr Val Pro 
                325                 330                 335


Leu Met Leu Val Asn Ala Ala Asp Asp Pro Leu Val His Glu Ser Leu 
            340                 345                 350


Leu Thr Ile Pro Lys Ser Leu Ser Glu Lys Arg Glu Asn Val Met Phe 
        355                 360                 365


Val Leu Pro Leu His Gly Gly His Leu Gly Phe Phe Glu Gly Ser Val 
    370                 375                 380


Leu Phe Pro Glu Pro Leu Thr Trp Met Asp Lys Leu Val Val Glu Tyr 
385                 390                 395                 400


Ala Asn Ala Ile Cys Gln Trp Glu Arg Asn Lys Leu Gln Cys Ser Asp 
                405                 410                 415


Thr Glu Gln Val Glu Ala Asp Leu Glu 
            420                 425


<210>  1070
<211>  8687
<212>  DNA
<213>  Homo sapiens

<400>  1070
agtagcgtct gggtccctgg actaaagccg tcaaatgtaa ccaattgctg aggagctctc     60

ccctaagaat cccgcctcca ctctgaggaa cagcttcgct gatcaatgga tcccctccta    120

gacgcaatga gcgcgcgggg caagtggaga agcggctgaa ctgcccaatg aacaagcggt    180

ttccgtggtt aggggcgtgg cagaagcggt cgtcaggggc gtggcggcag ttacttgggc    240

ggggccggta gcggcgggag ctgcactggc caggggttcc ggctgtatat ccatgagcgc    300

cgctggcagc cggggagctg caggaaccag actgggggcg agctgagcac ctgtagtcaa    360

tcacacgcag cttttaggtt tgtttgaata agagatctga cctgaccggc ccaactgtac    420

aactcttcaa ggaaaattcg tatttgcagt gggaagaata agtaacattg atcaagatga    480

atgccatgct ggagactccc gaactcccag ccgtgtttga tggagtgaag ctggctgcag    540

tggctgctgt gctgtacgtg atcgtccggt gtttgaacct gaagagcccc acagccccac    600

ctgacctcta cttccaggac tcggggctct cacgctttct gctcaagtcc tgtcctcttc    660

tgaccaaaga atacattcca ccgttgatct gggggaaaag tggacacatc cagacagcct    720

tgtatgggaa gatgggaagg gtgaggtcgc cacatcctta tgggcaccgg aagttcatca    780

ctatgtctga tggagccact tctacattcg acctcttcga gcccttggct gagcactgtg    840

ttggagatga tatcaccatg gtcatctgcc ctggaattgc caatcacagc gagaagcaat    900

acatccgcac tttcgttgac tacgcccaga aaaatggcta tcggtgcgcc gtgctgaacc    960

acctgggtgc cctgcccaac attgaattga cctcgccacg catgttcacc tatggctgca   1020

cgtgggaatt tggagccatg gtgaactaca tcaagaagac atatcccctg acccagctgg   1080

tcgtcgtggg cttcagcctg ggtggtaaca ttgtgtgcaa atacttgggg gagactcagg   1140

caaaccaaga gaaggtcctg tgctgcgtca gcgtgtgcca ggggtacagt gcactgaggg   1200

cccaggaaac cttcatgcaa tgggatcagt gccggcggtt ctacaacttc ctcatggctg   1260

acaacatgaa gaagatcatc ctctcgcaca ggcaagctct ttttggagac catgttaaga   1320

aaccccagag cctggaagac acggacttga gccggctcta cacagcaaca tccctgatgc   1380

agattgatga caatgtgatg aggaagtttc acggctataa ctccctgaag gaatactatg   1440

aggaagaaag ttgcatgcgg tacctgcaca ggatttatgt tcctctcatg ctggttaatg   1500

cagctgacga tccgttggtg catgaaagtc ttctaaccat tccaaaatct ctttcagaga   1560

aacgagagaa cgtcatgttt gtgctgcctc tgcatggggg ccacttgggc ttctttgagg   1620

gctctgtgct gttccccgag cccctgacat ggatggataa gctggtggtg gagtacgcca   1680

acgccatttg ccaatgggag cgtaacaagt tgcagtgctc tgacacggag caggtggagg   1740

ccgacctgga gtgaggcctc cggactctgg cacgctccag cagccctcct ctggaagctg   1800

cgtcccctca ccccctgttt caggtctccc atctccctca gtgacctgga tctgacctca   1860

caccatcagc agggggcacc caccatgcac acctgtctcg gagtaggcag ctcttcctgg   1920

gagctccagg ctatttttgt gcttagttac tggttttctc cattgcattg ttaggcatgg   1980

tgacaagtga cagagttctt gccctctgtc cagtttcagc atctggttgc ttttaagcca   2040

agtacatcta gtttccctat taaaaatgtg tctgaatagc gattttgctt tgccaccaaa   2100

aggcttttcc ctgagaacag tgaaggatgt atgtcatttt gtggtggttg tatgtgtcct   2160

tacatagacc ttaaaaagag ctcacccttc caggccaatg ctgaagacac agctccgctt   2220

gggagcctga gaacccaggc ttcccaggcc agagtgtggc ttcttaaacg gcaaaggaaa   2280

ttcctttgag tcacaagcca agttttcgcc ctgtctcctg agaccatttc cctacgcttt   2340

gctgctgctg agagttacgt gaggcacttg ttaaaaattc agcctcccag gtccctcccc   2400

tcggagaggc tgattcactg ggtctgggaa ggagcctggg gattttaatt tttcacaagt   2460

gccccagatg attctcatca ccaagcaaat tttggaaatg ctgttcaaca gcgcccttaa   2520

attggaaaca tctttgcagc tcgttttatt gaaattcata atcaggggtg tcctctagct   2580

cccacggtct ccagagcagc aaggccggct atggagctgc cgtcgtgtga ccacagtgtg   2640

atgtctcaga agggctctgg gtgggctgag catctgggct gtgccctggc tctgcttttc   2700

accctggaca aagtcgctgt ggacttcaat ttcttcacct ctaaaatggg ggacttggac   2760

caggtagatt gctgagctca ctaccaggtt caaagttcaa tgacaaactc agtttactga   2820

ggtttgagag aacatccctc caggggagcc tgggagctgc tctcccagtc taagcatgta   2880

gatatcatcg tttgcctttt gtgtgtgtgt gtcccttatt tgataaaaag atgttttgag   2940

ttgttttttt tttaagcact cacttgtaat tttagttttt aaacccaagt ccctctaact   3000

ttgcctttga taccaaacaa ttcaaaagtt ggatctgagt ttggagaaag atatttccaa   3060

cctaagtggg tattattttg aaaccagatt tttaatttaa tagcctatat ttgtagtctg   3120

ttggataggt gtttccaaag tgtgtcttct caagtgaaaa cgcaactcta ggtttcaagt   3180

actccttttc tccgatcctg tggtacttga atatccaaaa accctgcact ttgaacaatc   3240

agctgttgct atctggaact aaacagaact atgagtaaaa ttgcctggat actttaaaaa   3300

gatatttttc ctccttcatc tcctttgact ccaggacaga ctggaatata agtagtgggt   3360

ctgcatggat gtttcaggga tcaaaggagc cacctgggcg cctgagtgcc aaccctcagg   3420

gccacaggtg ggtgtggttt gggcacgggt ccaagtgact gtgacgggac ccgtgggcat   3480

gggtccaggt ctgtaacctg aagaagttgt tttctgacaa tcaccaaatc atccgaatga   3540

catcaaaagc agcccttatc tcagagactg agatttctgt ggtctcaact tcgctttggt   3600

ataatttctg gcactcacca gcctctatca ttatgacttt ccccccagtg tattatttct   3660

ctaataggtt tccttttcac gttcttttag cacagactgg cactttaccc tctcagtttg   3720

gaagttagcc cctctcctct gttacttttc ccttcaccca actacagctg tgatctagaa   3780

cattcatagt catatttctg ctactactac cttcatttat caagactttt tatgagaata   3840

ggtaaaccaa gcaataactt cctaggactg aatcaccacc ccagaagagc gagaggctcc   3900

tttcatatgc ctgaggccac accccttaac ctgttctgac aaaatagtgg ctggcccatg   3960

taccagctcc attcagaaat tcaggaagag aaaagacagc cctgttgtca cacaaaccgg   4020

tgtgggggag ggtggagcct ggtctgcacg gcagtcctgg tggcccctgt ggaggacagg   4080

cagggctggc agcatagcct ttgttgccac acaaccggaa tttgctcccc caggactgtg   4140

ggagccagtg tcccagctga aatcttttta gtgtgtggct ctgaatggca ctcacattcc   4200

attttggctc acatgaaact aactgaagcc ctttgttcaa gcttcaggct cttaggcatg   4260

gaaatgagaa tgtgactgtg gctgtcttac aggaaaattc ttgtttgtcc ctgaatgaga   4320

gcacagaggc attgaattca cagagctgca aacttgcctg ataaatgagg gagtggcagt   4380

ttatagatag gtcatctttt ttccttcctc caggtgtcct tgcctttctt cccaaagtca   4440

ttcatttctg atgagtatat gaatccccct cttgctagta aggttctatt tgggctaaaa   4500

caaggctgaa tttttaaaga gtatttgaat atattttaga atcaaattga ggctataaat   4560

tgcatcaatc tggacaattc cattgcagga ataatatgtt aaaaaccaat ggggagaagc   4620

acccacatct ctcctgtagc actccgtgtc tcataagcaa tttgaagaca cttacaagta   4680

actgattcca gtcaaattag gattaactga ctcaaaaaat ggtgtcaagt ttctttaatg   4740

tttttatgtt agaagtgagt ttaacagact tgaagaaaac tgttatcttt tcctgctgtg   4800

agtttacaca aatgattcca gagcagaatg aaagcagaaa gctgttggtt acaatattct   4860

tttaacctct ctgcagcatt ttacacttac tgggaacctt atgattcacc gtaagagtgg   4920

aaatatacct gagttcgtgt cctaatggtc tctaattcac attggatcgt gggcaaatca   4980

cctcacctct ctgagcctgt tccctcctct tagaccatct ctaagaccac ttcatctatt   5040

tacacatcat ttgcttgaac attgctgaac atctgcgtga acttggcctc tccagccctt   5100

gcaggtggaa acagctgtgt caaggctcaa ggctcacgct gaggggactt ggagggaggg   5160

ggcttctgca ttaagctttc ctggtgaaga cccttgatct tgtccaaagc cctgtgtctt   5220

tgactggctt ctcttcagag tccccgttgt catcgtaaga cccttgctgt ttggagggtg   5280

gtcttgtgac tgtggcagct gctggccgct ggaatgagga gcctatctcc atcctccagt   5340

gtgactcagg cagagcattg agaattccca gggcagaaat ccttcctgct caggctttca   5400

ttctaaaact acagtcttca ttaaagctga actttctggg tagctgagct tatatgcccg   5460

gcatctgaat gagagctctc tttgtaactg tgtgacttga gatctagttt gccagctcct   5520

gggaaacaat acatgtgttc ttgtttgtgt ttgctcagca agcagatgtc tgagatgtaa   5580

gaagcttttc ttttcctgtg gcattgattc tgacttagag ctgaagtaaa agatcactga   5640

aacatcacgt caagttgaag tcactcatag gtctttgtcc tttaggcagg acaggagagt   5700

cattaagaag catttcactg tagcattcta tcacaatatc atctggaatt gttttctttg   5760

cccagaaagc cttaacttgc ctctagagaa tccctggtat tacaacgata ttgcggcatt   5820

agaattccaa ctcttctgct gtggaagttt gaagcgaagc tgcagcaaaa ccagagaatt   5880

tcctcaagtg gcctgtaggc tccttgttat cttatgcccc cacccctccc tcaacaatat   5940

gagtgatcca gaactggccc aaacacctca gctctggtcc ctttttgccc ttcttggcct   6000

tactctgttg ttcaaagcca ctttggattg cttggatgct tcgaacagcc atgaaaagta   6060

gcctgcctgt ggcatttaga ggccaagcaa ttgacagaaa gggtttcttc tacctctgtt   6120

atctaagcag agggaagtaa acctctcacc gccccccacc cctcactgcc cccgattacc   6180

ctagaattgc tttcgccaaa ttgtagttga agctaaggaa ggggaatctg gcccctgctg   6240

ggagagggaa ctggaatgcc acacaaggca aggcctgctt ccttccttcc cctctgctgc   6300

tgctgcctcg gaacgctgca gcccaggctt cctcccacag tggcccttgg aagcaggccg   6360

cagagtagac agctgctcct tttggaagag tcagtcccct gtgttttctg aactgttttt   6420

cctagcatgt atgtgggtag agctttcatg catctctagt aataataagc tgaaattagt   6480

ttttttttta attctccaat ttaaaacttt taattaaaaa gtaaatttta atgtcgaaaa   6540

tgcaaacttg gggagggcag aaagatcaca cacaaggctg tcacttcata cttgcaggat   6600

tgcacagcag ccgggcagag gcgctcctca cttcccagat ggggcggcgg gcagcagaga   6660

cgcacctcac ttcctagaca gtgcggcagc caggcacagg cacacctcac ttcccagaca   6720

gttgggcggc caggcaagcg ctcctcactt cccagatggg gcggctcccg ggaagcgggg   6780

ctcctcactt cccagacagg gtggccaggc agaggtgctc ctcacttccc agaacaattc   6840

tttatgaatt tgataaagga ctgaagtgca actgaaagct gctagtgatg atctggtaat   6900

atacaatttg tccagtagcc agtttgtttt tattgtgttt tctaaccata agagatcatt   6960

aaaggcaaag cctgtatgac gctgtacaca cacaaaaaaa tggtcaccgc aggccatact   7020

accaatgaaa tggtaggtaa acaaatcttc tggtcaagag aaaaaaaaaa gaaatagcac   7080

tctgcatgct ttgctctaca agacgaattt ccctagaaag aatccaatga aggccgggca   7140

tagtggctca ctcctgtaat cccagcactt tggaggccga ggcgggtaga tcacctgagg   7200

ttaggagttc aagaccagcc tggccaacat ggtgaaaccc cttctctact aaaaatgcaa   7260

aaattagctg ggtgtggtgg cgggcgcctg taatcccagc tactcgggag gctgaggtgg   7320

gagaattgct tgaacccagg agacggaggt tgcagtgagc cgagatcacg cctctgcact   7380

ccagcctggg caacaagagt gagactccgt ctccaaaaaa agaaaaggaa tccagtgaaa   7440

atggctgcaa ttacaacaag aagtgaagga agaagactgg tgacatctct gaaggatgca   7500

gttgaggttg atccaggttt atccgaatat gctacctttc tgagccttaa accttcatct   7560

ctcaggtgtt gatttgcttc tgatagcttc atcatttctc cctgaagtct tttacactct   7620

tctgttagtt tccttgtttc agtatcatga agtgaagcac tgtgtggttg tggcgtgggc   7680

ccgtcttgct tagatgcatt cagtgggaca gctttgctgg gttccatgtc attcaattta   7740

tcattttcat tggggatctc catttggaat ccattaattc atgaggtttt gcctcattcc   7800

acacagcttc catatctgaa gtgtttagtg gagcaaaaat tgtaccataa acttgtgttt   7860

actcttttca ttcggatcat agtcaaaggg ctgtagcatt actgaaacag tcacagttga   7920

ccctgggtca ataattccac tgttgggcct cacacagtac cggtgaggca cggtagtctt   7980

cactttgaaa cacacttttc tatccgatgg atttcgcaat ttaagatttg tagtgactac   8040

atctgtgaag gggcctttga atttgaggtc tatgggcggg tcgaggacca ggatctgctc   8100

gtgcttcgcc gtggccccgg aggcagacgc cattggagag acagcgcaga gcagggggcg   8160

gcttgctcgc tgggggcggg ggacgatggc gagaggggag ggggagcgag ttcgcatctc   8220

tccttttcct ggttagactc tgttcaacca cattcttatg ttggcagatc tgcttccaga   8280

ttgattttta gagcaccatc actttcacat tcctgattct gattttgttt tgttttgttt   8340

gggttttctg aaacttaaaa tgctgccccg aaaatactat atttttgagt ttgtgttctg   8400

aaagcctccg tgctgctgga tctttggggg gaaatacagg atccttcagc actgaggtgt   8460

ttaagatttg caactagcaa tgcaattttt tctaaatatg gggatattta cctttattaa   8520

gaaattatac taaacattga tgtccttgat cattttatgt tctcatatta cttttgattc   8580

tactatgatt gtgtggtggt gaacaaagat cattacaaac aaaaactgta attttgttat   8640

atttgattca atggaattta cctaaaaaat aaagactaaa aatgtgg                 8687


<210>  1071
<211>  425
<212>  PRT
<213>  Homo sapiens

<400>  1071

Met Asn Ala Met Leu Glu Thr Pro Glu Leu Pro Ala Val Phe Asp Gly 
1               5                   10                  15


Val Lys Leu Ala Ala Val Ala Ala Val Leu Tyr Val Ile Val Arg Cys 
            20                  25                  30


Leu Asn Leu Lys Ser Pro Thr Ala Pro Pro Asp Leu Tyr Phe Gln Asp 
        35                  40                  45


Ser Gly Leu Ser Arg Phe Leu Leu Lys Ser Cys Pro Leu Leu Thr Lys 
    50                  55                  60


Glu Tyr Ile Pro Pro Leu Ile Trp Gly Lys Ser Gly His Ile Gln Thr 
65                  70                  75                  80


Ala Leu Tyr Gly Lys Met Gly Arg Val Arg Ser Pro His Pro Tyr Gly 
                85                  90                  95


His Arg Lys Phe Ile Thr Met Ser Asp Gly Ala Thr Ser Thr Phe Asp 
            100                 105                 110


Leu Phe Glu Pro Leu Ala Glu His Cys Val Gly Asp Asp Ile Thr Met 
        115                 120                 125


Val Ile Cys Pro Gly Ile Ala Asn His Ser Glu Lys Gln Tyr Ile Arg 
    130                 135                 140


Thr Phe Val Asp Tyr Ala Gln Lys Asn Gly Tyr Arg Cys Ala Val Leu 
145                 150                 155                 160


Asn His Leu Gly Ala Leu Pro Asn Ile Glu Leu Thr Ser Pro Arg Met 
                165                 170                 175


Phe Thr Tyr Gly Cys Thr Trp Glu Phe Gly Ala Met Val Asn Tyr Ile 
            180                 185                 190


Lys Lys Thr Tyr Pro Leu Thr Gln Leu Val Val Val Gly Phe Ser Leu 
        195                 200                 205


Gly Gly Asn Ile Val Cys Lys Tyr Leu Gly Glu Thr Gln Ala Asn Gln 
    210                 215                 220


Glu Lys Val Leu Cys Cys Val Ser Val Cys Gln Gly Tyr Ser Ala Leu 
225                 230                 235                 240


Arg Ala Gln Glu Thr Phe Met Gln Trp Asp Gln Cys Arg Arg Phe Tyr 
                245                 250                 255


Asn Phe Leu Met Ala Asp Asn Met Lys Lys Ile Ile Leu Ser His Arg 
            260                 265                 270


Gln Ala Leu Phe Gly Asp His Val Lys Lys Pro Gln Ser Leu Glu Asp 
        275                 280                 285


Thr Asp Leu Ser Arg Leu Tyr Thr Ala Thr Ser Leu Met Gln Ile Asp 
    290                 295                 300


Asp Asn Val Met Arg Lys Phe His Gly Tyr Asn Ser Leu Lys Glu Tyr 
305                 310                 315                 320


Tyr Glu Glu Glu Ser Cys Met Arg Tyr Leu His Arg Ile Tyr Val Pro 
                325                 330                 335


Leu Met Leu Val Asn Ala Ala Asp Asp Pro Leu Val His Glu Ser Leu 
            340                 345                 350


Leu Thr Ile Pro Lys Ser Leu Ser Glu Lys Arg Glu Asn Val Met Phe 
        355                 360                 365


Val Leu Pro Leu His Gly Gly His Leu Gly Phe Phe Glu Gly Ser Val 
    370                 375                 380


Leu Phe Pro Glu Pro Leu Thr Trp Met Asp Lys Leu Val Val Glu Tyr 
385                 390                 395                 400


Ala Asn Ala Ile Cys Gln Trp Glu Arg Asn Lys Leu Gln Cys Ser Asp 
                405                 410                 415


Thr Glu Gln Val Glu Ala Asp Leu Glu 
            420                 425


<210>  1072
<211>  6265
<212>  DNA
<213>  Homo sapiens

<400>  1072
cacaccacat ttttagtctt tattttttag gtaaattcca ttgaatcaaa tataacaaaa     60

ttacagtttt tgtttgtaat gatctttgtt caccaccaca caatcatagt agaatcaaaa    120

gtaatatgag aacataaaat gatcaaggac atcaatgttt agtataattt cttaataaag    180

gtaaatatcc ccatatttag aaaaaattgc attgctagtt gcaaatctta aacacctcag    240

tgctgaagga tcctgtattt ccccccaaag atccagcagc acggaggctt tcagaacaca    300

aactcaaaaa tatagtattt tcggggcagc attttaagtt tcagaaaacc caaacaaaac    360

aaaacaaaat cagaatcagg aatgtgaaag tgatggtgct ctaaaaatca atctggaagc    420

agatctgcca acataagaat gtggttgaac agagtctaac caggaaaagg agagatgcga    480

actcgctccc cctcccctct cgccatcgtc ccccgccccc agcgagcaag ccgccccctg    540

ctctgcgctg tctctccaat ggcgtctgcc tccggggcca cggcgaagca cgagcagatc    600

ctggtcctcg acccgcccat agacctcaaa ttcaaaggcc ccttcacaga tgtagtcact    660

acaaatctta aattgcgaaa tccatcggat agaaaagtgt gtttcaaagt gaagactacc    720

gtgcctcacc ggtactgtgt gaggcccaac agtggaatta ttgacccagg gtcaactgtg    780

actgtttcag taatgctaca gccctttgac tatgatccga atgaaaagag taaacacaag    840

tttatggtac aatttttgct ccactaaaca cttcagatat ggaagctgtg tggaatgagg    900

caaaacctca tgaattaatg gattccaaat ggagatcccc aatgaaaatg ataaattgaa    960

tgacatggaa cccagcaaag ctgtcccact gaatgcatct aagcaagacg ggcccacgcc   1020

acaaccacac agtgcttcac ttcatgatac tgaaacaagg aaactaacag aagagtgtaa   1080

aagacttcag ggagaaatga tgaagctatc agaagcaaat caacacctga gagatgaagg   1140

tttaaggctc agaaaggtag catattcgga taaacctgga tcaacctcaa ctgcatcctt   1200

cagagatgtc accagtcttc ttccttcact tcttgttgta attgcagcca tcttcattgg   1260

attctttcta gggaaattcg tcttgtagag caaagcatgc agagtgctat ttcttttttt   1320

tttctcttga ccagaagatt tgtttaccta ccatttcatt ggtagtatgg cctgcggtga   1380

ccattttttt gtgtgtgtac agcgtcatac aggctttgcc tttaatgatc tcttatggtt   1440

agaaaacaca ataaaaacaa actggctact ggacaaattg tatattacca gatcatcact   1500

agcagctttc agttgcactt cagtccttta tcaaattcat aaagaattgt tctgggaagt   1560

gaggagcacc tctgcctggc caccctgtct gggaagtgag gagccccgct tcccgggagc   1620

cgccccatct gggaagtgag gagcgcttgc ctggccgccc aactgtctgg gaagtgaggt   1680

gtgcctgtgc ctggctgccg cactgtctag gaagtgaggt gcgtctctgc tgcccgccgc   1740

cccatctggg aagtgaggag cgcctctgcc cggctgctgt gcaatcctgc aagtatgaag   1800

tgacagcctt gtgtgtgatc tttctgccct ccccaagttt gcattttcga cattaaaatt   1860

tactttttaa ttaaaagttt taaattggag aattaaaaaa aaaactaatt tcagcttatt   1920

attactagag atgcatgaaa gctctaccca catacatgct aggaaaaaca gttcagaaaa   1980

cacaggggac tgactcttcc aaaaggagca gctgtctact ctgcggcctg cttccaaggg   2040

ccactgtggg aggaagcctg ggctgcagcg ttccgaggca gcagcagcag aggggaagga   2100

aggaagcagg ccttgccttg tgtggcattc cagttccctc tcccagcagg ggccagattc   2160

cccttcctta gcttcaacta caatttggcg aaagcaattc tagggtaatc gggggcagtg   2220

aggggtgggg ggcggtgaga ggtttacttc cctctgctta gataacagag gtagaagaaa   2280

ccctttctgt caattgcttg gcctctaaat gccacaggca ggctactttt catggctgtt   2340

cgaagcatcc aagcaatcca aagtggcttt gaacaacaga gtaaggccaa gaagggcaaa   2400

aagggaccag agctgaggtg tttgggccag ttctggatca ctcatattgt tgagggaggg   2460

gtgggggcat aagataacaa ggagcctaca ggccacttga ggaaattctc tggttttgct   2520

gcagcttcgc ttcaaacttc cacagcagaa gagttggaat tctaatgccg caatatcgtt   2580

gtaataccag ggattctcta gaggcaagtt aaggctttct gggcaaagaa aacaattcca   2640

gatgatattg tgatagaatg ctacagtgaa atgcttctta atgactctcc tgtcctgcct   2700

aaaggacaaa gacctatgag tgacttcaac ttgacgtgat gtttcagtga tcttttactt   2760

cagctctaag tcagaatcaa tgccacagga aaagaaaagc ttcttacatc tcagacatct   2820

gcttgctgag caaacacaaa caagaacaca tgtattgttt cccaggagct ggcaaactag   2880

atctcaagtc acacagttac aaagagagct ctcattcaga tgccgggcat ataagctcag   2940

ctacccagaa agttcagctt taatgaagac tgtagtttta gaatgaaagc ctgagcagga   3000

aggatttctg ccctgggaat tctcaatgct ctgcctgagt cacactggag gatggagata   3060

ggctcctcat tccagcggcc agcagctgcc acagtcacaa gaccaccctc caaacagcaa   3120

gggtcttacg atgacaacgg ggactctgaa gagaagccag tcaaagacac agggctttgg   3180

acaagatcaa gggtcttcac caggaaagct taatgcagaa gccccctccc tccaagtccc   3240

ctcagcgtga gccttgagcc ttgacacagc tgtttccacc tgcaagggct ggagaggcca   3300

agttcacgca gatgttcagc aatgttcaag caaatgatgt gtaaatagat gaagtggtct   3360

tagagatggt ctaagaggag ggaacaggct cagagaggtg aggtgatttg cccacgatcc   3420

aatgtgaatt agagaccatt aggacacgaa ctcaggtata tttccactct tacggtgaat   3480

cataaggttc ccagtaagtg taaaatgctg cagagaggtt aaaagaatat tgtaaccaac   3540

agctttctgc tttcattctg ctctggaatc atttgtgtaa actcacagca ggaaaagata   3600

acagttttct tcaagtctgt taaactcact tctaacataa aaacattaaa gaaacttgac   3660

accatttttt gagtcagtta atcctaattt gactggaatc agttacttgt aagtgtcttc   3720

aaattgctta tgagacacgg agtgctacag gagagatgtg ggtgcttctc cccattggtt   3780

tttaacatat tattcctgca atggaattgt ccagattgat gcaatttata gcctcaattt   3840

gattctaaaa tatattcaaa tactctttaa aaattcagcc ttgttttagc ccaaatagaa   3900

ccttactagc aagaggggga ttcatatact catcagaaat gaatgacttt gggaagaaag   3960

gcaaggacac ctggaggaag gaaaaaagat gacctatcta taaactgcca ctccctcatt   4020

tatcaggcaa gtttgcagct ctgtgaattc aatgcctctg tgctctcatt cagggacaaa   4080

caagaatttt cctgtaagac agccacagtc acattctcat ttccatgcct aagagcctga   4140

agcttgaaca aagggcttca gttagtttca tgtgagccaa aatggaatgt gagtgccatt   4200

cagagccaca cactaaaaag atttcagctg ggacactggc tcccacagtc ctgggggagc   4260

aaattccggt tgtgtggcaa caaaggctat gctgccagcc ctgcctgtcc tccacagggg   4320

ccaccaggac tgccgtgcag accaggctcc accctccccc acaccggttt gtgtgacaac   4380

agggctgtct tttctcttcc tgaatttctg aatggagctg gtacatgggc cagccactat   4440

tttgtcagaa caggttaagg ggtgtggcct caggcatatg aaaggagcct ctcgctcttc   4500

tggggtggtg attcagtcct aggaagttat tgcttggttt acctattctc ataaaaagtc   4560

ttgataaatg aaggtagtag tagcagaaat atgactatga atgttctaga tcacagctgt   4620

agttgggtga agggaaaagt aacagaggag aggggctaac ttccaaactg agagggtaaa   4680

gtgccagtct gtgctaaaag aacgtgaaaa ggaaacctat tagagaaata atacactggg   4740

gggaaagtca taatgataga ggctggtgag tgccagaaat tataccaaag cgaagttgag   4800

accacagaaa tctcagtctc tgagataagg gctgcttttg atgtcattcg gatgatttgg   4860

tgattgtcag aaaacaactt cttcaggtta cagacctgga cccatgccca cgggtcccgt   4920

cacagtcact tggacccgtg cccaaaccac acccacctgt ggccctgagg gttggcactc   4980

aggcgcccag gtggctcctt tgatccctga aacatccatg cagacccact acttatattc   5040

cagtctgtcc tggagtcaaa ggagatgaag gaggaaaaat atctttttaa agtatccagg   5100

caattttact catagttctg tttagttcca gatagcaaca gctgattgtt caaagtgcag   5160

ggtttttgga tattcaagta ccacaggatc ggagaaaagg agtacttgaa acctagagtt   5220

gcgttttcac ttgagaagac acactttgga aacacctatc caacagacta caaatatagg   5280

ctattaaatt aaaaatctgg tttcaaaata atacccactt aggttggaaa tatctttctc   5340

caaactcaga tccaactttt gaattgtttg gtatcaaagg caaagttaga gggacttggg   5400

tttaaaaact aaaattacaa gtgagtgctt aaaaaaaaaa caactcaaaa catcttttta   5460

tcaaataagg gacacacaca cacaaaaggc aaacgatgat atctacatgc ttagactggg   5520

agagcagctc ccaggctccc ctggagggat gttctctcaa acctcagtaa actgagtttg   5580

tcattgaact ttgaacctgg tagtgagctc agcaatctac ctggtccaag tcccccattt   5640

tagaggtgaa gaaattgaag tccacagcga ctttgtccag ggtgaaaagc agagccaggg   5700

cacagcccag atgctcagcc cacccagagc ccttctgaga catcacactg tggtcacacg   5760

acggcagctc catagccggc cttgctgctc tggagaccgt gggagctaga ggacacccct   5820

gattatgaat ttcaataaaa cgagctgcaa agatgtttcc aatttaaggg cgctgttgaa   5880

cagcatttcc aaaatttgct tggtgatgag aatcatctgg ggcacttgtg aaaaattaaa   5940

atccccaggc tccttcccag acccagtgaa tcagcctctc cgaggggagg gacctgggag   6000

gctgaatttt taacaagtgc ctcacgtaac tctcagcagc agcaaagcgt agggaaatgg   6060

tctcaggaga cagggcgaaa acttggcttg tgactcaaag gaatttcctt tgccgtttaa   6120

gaagccacac tctggcctgg gaagcctggg ttctcaggct cccaagcgga gctgtgtctt   6180

cagcattggc ctggaagggt gagctctttt taaggtctat gtaaggacac atacaaccac   6240

cacaaaatga catacatcct tcact                                         6265


<210>  1073
<211>  1752
<212>  DNA
<213>  Homo sapiens

<400>  1073
gagcccgatt taacggaaac tgtgggcggt gagaagttcc ttatgacaca ctaatcccaa     60

cctgctgacc ggaccacgcc tccagcggag ggaacctcta gagctccagg acattcaggt    120

accaggtagc cccaaggagg agctgccgac ctggcaggga acaaccaaga ctggggttaa    180

atctcacagc ctgcaagtgg aagagaagaa cttgaaccca ggtccaactt ttgcgccaca    240

gcaggctgcc tcttggtcct gacaggaagt cacaacttgg ccctgacttc ctatcctagg    300

gaaggggccg gctggagagg ccaggacaga gaaagcagat cccttctttt tccaaggact    360

ctgtgtcttc cataggcaac atgtcagaag gggtgggcac gttccgcatg gtacctgaag    420

aggaacagga gctccgtgcc caactggagc agctcacaac caaggaccat ggacctgtct    480

ttggcccgtg cagccagctg ccccgccaca ccttgcagaa ggccaaggat gagctgaacg    540

agagagagga gacccgggag gaggcagtgc gagagctgca ggagatggtg caggcgcagg    600

cggcctcggg ggaggagctg gcggtggccg tggcggagag ggtgcaagag aaggacagcg    660

gcttcttcct gcgcttcatc cgcgcacgga agttcaacgt gggccgtgcc tatgagctgc    720

tcagaggcta tgtgaatttc cggctgcagt accctgagct ctttgacagc ctgtccccag    780

aggctgtccg ctgcaccatt gaagctggct accctggtgt cctctctagt cgggacaagt    840

atggccgagt ggtcatgctc ttcaacattg agaactggca aagtcaagaa atcacctttg    900

atgagatctt gcaggcatat tgcttcatcc tggagaagct gctggagaat gaggaaactc    960

aaatcaatgg cttctgcatc attgagaact tcaagggctt taccatgcag caggctgcta   1020

gtctccggac ttcagatctc aggaagatgg tggacatgct ccaggattcc ttcccagccc   1080

ggttcaaagc catccacttc atccaccagc catggtactt caccacgacc tacaatgtgg   1140

tcaagccctt cttgaagagc aagctgcttg agagggtctt tgtccacggg gatgaccttt   1200

ctggtttcta ccaggagatc gatgagaaca tcctgccctc tgacttcggg ggcacgctgc   1260

ccaagtatga tggcaaggcc gttgctgagc agctctttgg cccccaggcc caagctgaga   1320

acacagcctt ctgaaaacat ctcctgccag ctgaactgta gttagaatct ctgggcctct   1380

cctcaactgt cctggaccca aggctaggaa agggctgctt gagatgactg tggtcccccc   1440

ttagactccc taagcccgag tgagctcagg tgtcaccctg ttctcaagtt gggggatggg   1500

taataaagga gggggaattc ccttgaacaa gaagaactgg ggatagttat atttccacct   1560

gcccttgaag ctttaagaca gtgatttttg tgtaaggttg tatttcaaag actcgaattc   1620

attttctcag tcatttcctt tgtaacagag ttttacgact tagagtctgt gaaaacaggc   1680

aaggagcccg ggttaaaata tccccctatt cgcccccaaa atgcaataaa agaagataaa   1740

agagagagga ta                                                       1752


<210>  1074
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  1074

Met Ser Glu Gly Val Gly Thr Phe Arg Met Val Pro Glu Glu Glu Gln 
1               5                   10                  15


Glu Leu Arg Ala Gln Leu Glu Gln Leu Thr Thr Lys Asp His Gly Pro 
            20                  25                  30


Val Phe Gly Pro Cys Ser Gln Leu Pro Arg His Thr Leu Gln Lys Ala 
        35                  40                  45


Lys Asp Glu Leu Asn Glu Arg Glu Glu Thr Arg Glu Glu Ala Val Arg 
    50                  55                  60


Glu Leu Gln Glu Met Val Gln Ala Gln Ala Ala Ser Gly Glu Glu Leu 
65                  70                  75                  80


Ala Val Ala Val Ala Glu Arg Val Gln Glu Lys Asp Ser Gly Phe Phe 
                85                  90                  95


Leu Arg Phe Ile Arg Ala Arg Lys Phe Asn Val Gly Arg Ala Tyr Glu 
            100                 105                 110


Leu Leu Arg Gly Tyr Val Asn Phe Arg Leu Gln Tyr Pro Glu Leu Phe 
        115                 120                 125


Asp Ser Leu Ser Pro Glu Ala Val Arg Cys Thr Ile Glu Ala Gly Tyr 
    130                 135                 140


Pro Gly Val Leu Ser Ser Arg Asp Lys Tyr Gly Arg Val Val Met Leu 
145                 150                 155                 160


Phe Asn Ile Glu Asn Trp Gln Ser Gln Glu Ile Thr Phe Asp Glu Ile 
                165                 170                 175


Leu Gln Ala Tyr Cys Phe Ile Leu Glu Lys Leu Leu Glu Asn Glu Glu 
            180                 185                 190


Thr Gln Ile Asn Gly Phe Cys Ile Ile Glu Asn Phe Lys Gly Phe Thr 
        195                 200                 205


Met Gln Gln Ala Ala Ser Leu Arg Thr Ser Asp Leu Arg Lys Met Val 
    210                 215                 220


Asp Met Leu Gln Asp Ser Phe Pro Ala Arg Phe Lys Ala Ile His Phe 
225                 230                 235                 240


Ile His Gln Pro Trp Tyr Phe Thr Thr Thr Tyr Asn Val Val Lys Pro 
                245                 250                 255


Phe Leu Lys Ser Lys Leu Leu Glu Arg Val Phe Val His Gly Asp Asp 
            260                 265                 270


Leu Ser Gly Phe Tyr Gln Glu Ile Asp Glu Asn Ile Leu Pro Ser Asp 
        275                 280                 285


Phe Gly Gly Thr Leu Pro Lys Tyr Asp Gly Lys Ala Val Ala Glu Gln 
    290                 295                 300


Leu Phe Gly Pro Gln Ala Gln Ala Glu Asn Thr Ala Phe 
305                 310                 315


<210>  1075
<211>  4569
<212>  DNA
<213>  Homo sapiens

<400>  1075
tcttgttgtt acgggtaacg gaagtgtggc ggcgttgggt tgagcgggct ttttggaagt     60

ttgtggcgga gttctgtgat atgagcaaca atggaccaga agattttatc tctagcagca    120

gaaaaaacag cagacaaact gcaagaattt cttcaaaccc tgagagaagg tgatttgact    180

aatctccttc agaatcaagc agtgaaagga aaagttgctg gagcactcct gagagccatc    240

ttcaaaggtt ccccctgctc tgaggaagct ggaacactta ggagacgtaa gatatacact    300

tgttgtatcc agttggtgga atcgggggat ttgcagaaag aaatagcgtc tgagatcata    360

ggattactga tgctggaggc tcaccatttt ccaggaccat tattggttga attagccaat    420

gagtttatta gtgctgtcag agaaggcagc ctagtgaatg gaaaatcttt ggagttacta    480

cctatcattc tcactgccct ggctacgaaa aaggaaaatc tggcttatgg aaaaggtgta    540

ctgagtgggg aagaatgtaa gaaacagttg attaacaccc tgtgttctgg caggtgggat    600

cagcaatatg taatccaact cacctccatg ttcaaggatg tccctctgac tgcagaagag    660

gtggaatttg tggtggaaaa agcattgagc atgttctcca agatgaatct tcaagaaata    720

ccacctttgg tctatcagct tctggttctc tcctccaagg gaagcagaaa gagtgttttg    780

gaaggaatca tagccttctt cagtgcacta gataagcagc acaatgagga acagagtggt    840

gacgagctat tggatgttgt cactgtgcca tcaggtgaac ttcgtcatgt ggaaggcacc    900

attattctac acattgtgtt tgccatcaaa ttggactatg aactaggcag agaactcgtg    960

aaacacttaa aggtaggaca gcaaggagat tccaataata acttaagtcc cttcagcatt   1020

gctcttcttc tgtctgtaac aagaatacaa agatttcagg accaggtgct tgatctttta   1080

aagacttcgg ttgtaaagag ctttaaggat cttcaactcc tccaaggctc aaaatttctt   1140

cagaatctag ttcctcatag atcttatgtt tcaaccatga tcttggaagt agtgaagaat   1200

agcgttcata gctgggacca tgttactcag ggcctcgtag aacttggttt cattttgatg   1260

gattcatatg ggccaaagaa ggttcttgat ggaaaaacta ttgaaaccag cccaagtctt   1320

tctagaatgc caaaccagca tgcatgtaag ctcggagcta atatcctgtt ggaaactttt   1380

aagatccatg agatgatcag acaagaaatt ttggagcagg tcctcaacag ggttgttacc   1440

agagcatctt ctcccatcag tcatttctta gacctgcttt caaatatcgt catgtatgca   1500

cccttagttc ttcaaagttg ttcttctaaa gtcacagaag cttttgacta tttgtccttt   1560

ctgccccttc agactgtaca aaggctgctt aaggcagtgc agccccttct caaagtcagc   1620

atgtcaatga gagactgctt gatacttgtc cttcggaaag ctatgtttgc caaccagctt   1680

gatgcccgaa aatctgcagt tgctgggttt ttgctgctcc tgaagaactt taaagtttta   1740

ggcagcctgt catcctctca gtgcagtcag tctctcagtg tcagtcaggt tcatgtggat   1800

gttcacagcc attacaattc tgtcgccaat gaaacttttt gccttgagat catggatagt   1860

ttgaggagat gcttaagcca gcaagctgat gttcgactca tgctttatga ggggttttat   1920

gatgttcttc gaaggaactc tcagctggct aattcagtca tgcaaactct gctctcacag   1980

ttaaaacagt tctatgagcc aaaacctgat ctgctgcctc ctctgaaatt agaagcttgt   2040

attctgaccc aaggagataa gatctctcta caagaaccac tggattatct gctgtgttgt   2100

attcagcatt gtttggcctg gtataagaat acagtcatac ccttacagca gggagaggag   2160

gaagaggagg aggaagaggc attctacgaa gacctagatg atatattgga gtccattact   2220

aatagaatga ttaagagtga gctggaagac tttgaactgg ataaatcagc agatttttct   2280

cagagcacca gtattggcat aaaaaataat atctgtgctt ttcttgtgat gggagtttgt   2340

gaggttttaa tagaatacaa tttctccata agtagtttca gtaagaatag gtttgaggac   2400

attctgagct tatttatgtg ttacaaaaaa ctctctgaca ttcttaatga aaaagcgggt   2460

aaagccaaaa ctaaaatggc caacaagaca agtgatagtc ttttgtccat gaaatttgtg   2520

tccagtcttc tcactgctct tttcagagtc ttgctatgga gatacacttc aattcctact   2580

tcagtggaag agtcgggaaa gaaagagaaa ggaaagagca tctcactgct gtgcttggag   2640

ggtttacaga aaatattcag tgctgtgcaa cagttctatc agcccaagat tcagcagttt   2700

ctcagagctc tggatgtcac agataaggaa ggagaagaga gagaagatgc agatgtcagt   2760

gtcactcaga gaacagcatt ccagatccgg caatttcaga ggtccttgtt gaatttactt   2820

agcagtcaag aggaagattt taatagcaaa gaagccctcc tgctagtcac ggttcttacc   2880

agtttgtcca agttactgga gccctcctct cctcagtttg tgcagatgtt atcctggaca   2940

tcaaagattt gcaaggaaaa cagccgggag gatgccttgt tttgcaagag cttgatgaac   3000

ttgctcttca gcctgcatgt ttcgtataag agtcctgtca ttctgctgcg tgacttgtcc   3060

caggatatcc acgggcatct gggagatata gaccaggatg tagaggtgga gaaaacaaac   3120

cactttgcaa tagtgaattt gagaacggct gcccccactg tctgtttact tgttctgagt   3180

caggccgaga aggttctaga agaagtggac tggctaatca ccaagcttaa gggacaagtg   3240

agccaagaaa ccttatcaga agaggcctct tctcaggcaa ccctaccaaa tcagcctgtt   3300

gagaaagcta tcatcatgca actgggaact ctgcttacat ttttccacga gctggtgcag   3360

acagctctgc catcaggcag ctgtgtggac accttgttaa aggacttgtg caaaatgtac   3420

accacactta cagcccttgt cagatattat ctccaggtgt gtcagagctc cggaggaatt   3480

ccaaaaaata tggaaaagct ggtgaagctg tctggttctc atctgacccc cctgtgttat   3540

tctttcattt cttacgtaca gaataagagt aagagcctga actatacggg agagaaaaag   3600

gagaaacctg ctgccgttgc cacagccatg gccagagttc ttcgggaaac caagccaatc   3660

cctaacctca tctttgccat agaacagtat gaaaaatttc tcatccacct ttctaagaag   3720

tccaaggtga acctgatgca gcacatgaag ctcagcacct cacgagactt caagatcaaa   3780

ggaaacatcc tagacatggt tcttcgagag gatggtgaag atgaaaatga agagggcact   3840

gcatcagagc atgggggaca gaacaaagaa ccagccaaga agaaaaggaa aaaataaatg   3900

aaatgcctga gttaatgtga actttggggc ttctgcttca tttttaccca acaagcaaca   3960

atgccccttg tcctgtagtc cacaccgatg ttggcatctt ggttctgaac ccactgaatt   4020

caactgcacc ttcagttaga aggaatcttc ttggcaggtc ctgctactga aaaatggctg   4080

gccttaggca agcccttttg caaaaagcac agctgaaagc ctgagtttgg gagcctgcac   4140

caccccgatg aagctccacg ggagcaaata cagagcctcc aggcagtgct atggtccagg   4200

ctggcttcgt ttttccaagg agcctttggt gagttcaatt atctggtaaa tatccagcgc   4260

ttcacctgaa agatagtgca aattggttag gatgccacct caagaactgt aactgagagc   4320

tcagaagtga gcaaaggagc ttaatgctaa ggtcaaaagg agagtgaaag gttgagaaca   4380

attgccacga acggtaatgt tacatgttag gagggtctgt tttcttttta tataagtgtg   4440

tcttagatat attttaaata gaaaataagc tttctgattt acttgtttgg tatttaaagc   4500

acagtttgtt tttctgtcac ctatagagtg caagaatgca ctctatagaa taaattatct   4560

ttaaacatt                                                           4569


<210>  1076
<211>  1268
<212>  PRT
<213>  Homo sapiens

<400>  1076

Met Asp Gln Lys Ile Leu Ser Leu Ala Ala Glu Lys Thr Ala Asp Lys 
1               5                   10                  15


Leu Gln Glu Phe Leu Gln Thr Leu Arg Glu Gly Asp Leu Thr Asn Leu 
            20                  25                  30


Leu Gln Asn Gln Ala Val Lys Gly Lys Val Ala Gly Ala Leu Leu Arg 
        35                  40                  45


Ala Ile Phe Lys Gly Ser Pro Cys Ser Glu Glu Ala Gly Thr Leu Arg 
    50                  55                  60


Arg Arg Lys Ile Tyr Thr Cys Cys Ile Gln Leu Val Glu Ser Gly Asp 
65                  70                  75                  80


Leu Gln Lys Glu Ile Ala Ser Glu Ile Ile Gly Leu Leu Met Leu Glu 
                85                  90                  95


Ala His His Phe Pro Gly Pro Leu Leu Val Glu Leu Ala Asn Glu Phe 
            100                 105                 110


Ile Ser Ala Val Arg Glu Gly Ser Leu Val Asn Gly Lys Ser Leu Glu 
        115                 120                 125


Leu Leu Pro Ile Ile Leu Thr Ala Leu Ala Thr Lys Lys Glu Asn Leu 
    130                 135                 140


Ala Tyr Gly Lys Gly Val Leu Ser Gly Glu Glu Cys Lys Lys Gln Leu 
145                 150                 155                 160


Ile Asn Thr Leu Cys Ser Gly Arg Trp Asp Gln Gln Tyr Val Ile Gln 
                165                 170                 175


Leu Thr Ser Met Phe Lys Asp Val Pro Leu Thr Ala Glu Glu Val Glu 
            180                 185                 190


Phe Val Val Glu Lys Ala Leu Ser Met Phe Ser Lys Met Asn Leu Gln 
        195                 200                 205


Glu Ile Pro Pro Leu Val Tyr Gln Leu Leu Val Leu Ser Ser Lys Gly 
    210                 215                 220


Ser Arg Lys Ser Val Leu Glu Gly Ile Ile Ala Phe Phe Ser Ala Leu 
225                 230                 235                 240


Asp Lys Gln His Asn Glu Glu Gln Ser Gly Asp Glu Leu Leu Asp Val 
                245                 250                 255


Val Thr Val Pro Ser Gly Glu Leu Arg His Val Glu Gly Thr Ile Ile 
            260                 265                 270


Leu His Ile Val Phe Ala Ile Lys Leu Asp Tyr Glu Leu Gly Arg Glu 
        275                 280                 285


Leu Val Lys His Leu Lys Val Gly Gln Gln Gly Asp Ser Asn Asn Asn 
    290                 295                 300


Leu Ser Pro Phe Ser Ile Ala Leu Leu Leu Ser Val Thr Arg Ile Gln 
305                 310                 315                 320


Arg Phe Gln Asp Gln Val Leu Asp Leu Leu Lys Thr Ser Val Val Lys 
                325                 330                 335


Ser Phe Lys Asp Leu Gln Leu Leu Gln Gly Ser Lys Phe Leu Gln Asn 
            340                 345                 350


Leu Val Pro His Arg Ser Tyr Val Ser Thr Met Ile Leu Glu Val Val 
        355                 360                 365


Lys Asn Ser Val His Ser Trp Asp His Val Thr Gln Gly Leu Val Glu 
    370                 375                 380


Leu Gly Phe Ile Leu Met Asp Ser Tyr Gly Pro Lys Lys Val Leu Asp 
385                 390                 395                 400


Gly Lys Thr Ile Glu Thr Ser Pro Ser Leu Ser Arg Met Pro Asn Gln 
                405                 410                 415


His Ala Cys Lys Leu Gly Ala Asn Ile Leu Leu Glu Thr Phe Lys Ile 
            420                 425                 430


His Glu Met Ile Arg Gln Glu Ile Leu Glu Gln Val Leu Asn Arg Val 
        435                 440                 445


Val Thr Arg Ala Ser Ser Pro Ile Ser His Phe Leu Asp Leu Leu Ser 
    450                 455                 460


Asn Ile Val Met Tyr Ala Pro Leu Val Leu Gln Ser Cys Ser Ser Lys 
465                 470                 475                 480


Val Thr Glu Ala Phe Asp Tyr Leu Ser Phe Leu Pro Leu Gln Thr Val 
                485                 490                 495


Gln Arg Leu Leu Lys Ala Val Gln Pro Leu Leu Lys Val Ser Met Ser 
            500                 505                 510


Met Arg Asp Cys Leu Ile Leu Val Leu Arg Lys Ala Met Phe Ala Asn 
        515                 520                 525


Gln Leu Asp Ala Arg Lys Ser Ala Val Ala Gly Phe Leu Leu Leu Leu 
    530                 535                 540


Lys Asn Phe Lys Val Leu Gly Ser Leu Ser Ser Ser Gln Cys Ser Gln 
545                 550                 555                 560


Ser Leu Ser Val Ser Gln Val His Val Asp Val His Ser His Tyr Asn 
                565                 570                 575


Ser Val Ala Asn Glu Thr Phe Cys Leu Glu Ile Met Asp Ser Leu Arg 
            580                 585                 590


Arg Cys Leu Ser Gln Gln Ala Asp Val Arg Leu Met Leu Tyr Glu Gly 
        595                 600                 605


Phe Tyr Asp Val Leu Arg Arg Asn Ser Gln Leu Ala Asn Ser Val Met 
    610                 615                 620


Gln Thr Leu Leu Ser Gln Leu Lys Gln Phe Tyr Glu Pro Lys Pro Asp 
625                 630                 635                 640


Leu Leu Pro Pro Leu Lys Leu Glu Ala Cys Ile Leu Thr Gln Gly Asp 
                645                 650                 655


Lys Ile Ser Leu Gln Glu Pro Leu Asp Tyr Leu Leu Cys Cys Ile Gln 
            660                 665                 670


His Cys Leu Ala Trp Tyr Lys Asn Thr Val Ile Pro Leu Gln Gln Gly 
        675                 680                 685


Glu Glu Glu Glu Glu Glu Glu Glu Ala Phe Tyr Glu Asp Leu Asp Asp 
    690                 695                 700


Ile Leu Glu Ser Ile Thr Asn Arg Met Ile Lys Ser Glu Leu Glu Asp 
705                 710                 715                 720


Phe Glu Leu Asp Lys Ser Ala Asp Phe Ser Gln Ser Thr Ser Ile Gly 
                725                 730                 735


Ile Lys Asn Asn Ile Cys Ala Phe Leu Val Met Gly Val Cys Glu Val 
            740                 745                 750


Leu Ile Glu Tyr Asn Phe Ser Ile Ser Ser Phe Ser Lys Asn Arg Phe 
        755                 760                 765


Glu Asp Ile Leu Ser Leu Phe Met Cys Tyr Lys Lys Leu Ser Asp Ile 
    770                 775                 780


Leu Asn Glu Lys Ala Gly Lys Ala Lys Thr Lys Met Ala Asn Lys Thr 
785                 790                 795                 800


Ser Asp Ser Leu Leu Ser Met Lys Phe Val Ser Ser Leu Leu Thr Ala 
                805                 810                 815


Leu Phe Arg Val Leu Leu Trp Arg Tyr Thr Ser Ile Pro Thr Ser Val 
            820                 825                 830


Glu Glu Ser Gly Lys Lys Glu Lys Gly Lys Ser Ile Ser Leu Leu Cys 
        835                 840                 845


Leu Glu Gly Leu Gln Lys Ile Phe Ser Ala Val Gln Gln Phe Tyr Gln 
    850                 855                 860


Pro Lys Ile Gln Gln Phe Leu Arg Ala Leu Asp Val Thr Asp Lys Glu 
865                 870                 875                 880


Gly Glu Glu Arg Glu Asp Ala Asp Val Ser Val Thr Gln Arg Thr Ala 
                885                 890                 895


Phe Gln Ile Arg Gln Phe Gln Arg Ser Leu Leu Asn Leu Leu Ser Ser 
            900                 905                 910


Gln Glu Glu Asp Phe Asn Ser Lys Glu Ala Leu Leu Leu Val Thr Val 
        915                 920                 925


Leu Thr Ser Leu Ser Lys Leu Leu Glu Pro Ser Ser Pro Gln Phe Val 
    930                 935                 940


Gln Met Leu Ser Trp Thr Ser Lys Ile Cys Lys Glu Asn Ser Arg Glu 
945                 950                 955                 960


Asp Ala Leu Phe Cys Lys Ser Leu Met Asn Leu Leu Phe Ser Leu His 
                965                 970                 975


Val Ser Tyr Lys Ser Pro Val Ile Leu Leu Arg Asp Leu Ser Gln Asp 
            980                 985                 990


Ile His Gly His Leu Gly Asp Ile Asp Gln Asp Val Glu Val Glu Lys 
        995                 1000                1005


Thr Asn His Phe Ala Ile Val Asn Leu Arg Thr Ala Ala Pro Thr Val 
    1010                1015                1020


Cys Leu Leu Val Leu Ser Gln Ala Glu Lys Val Leu Glu Glu Val Asp 
1025                1030                1035                1040


Trp Leu Ile Thr Lys Leu Lys Gly Gln Val Ser Gln Glu Thr Leu Ser 
                1045                1050                1055


Glu Glu Ala Ser Ser Gln Ala Thr Leu Pro Asn Gln Pro Val Glu Lys 
            1060                1065                1070


Ala Ile Ile Met Gln Leu Gly Thr Leu Leu Thr Phe Phe His Glu Leu 
        1075                1080                1085


Val Gln Thr Ala Leu Pro Ser Gly Ser Cys Val Asp Thr Leu Leu Lys 
    1090                1095                1100


Asp Leu Cys Lys Met Tyr Thr Thr Leu Thr Ala Leu Val Arg Tyr Tyr 
1105                1110                1115                1120


Leu Gln Val Cys Gln Ser Ser Gly Gly Ile Pro Lys Asn Met Glu Lys 
                1125                1130                1135


Leu Val Lys Leu Ser Gly Ser His Leu Thr Pro Leu Cys Tyr Ser Phe 
            1140                1145                1150


Ile Ser Tyr Val Gln Asn Lys Ser Lys Ser Leu Asn Tyr Thr Gly Glu 
        1155                1160                1165


Lys Lys Glu Lys Pro Ala Ala Val Ala Thr Ala Met Ala Arg Val Leu 
    1170                1175                1180


Arg Glu Thr Lys Pro Ile Pro Asn Leu Ile Phe Ala Ile Glu Gln Tyr 
1185                1190                1195                1200


Glu Lys Phe Leu Ile His Leu Ser Lys Lys Ser Lys Val Asn Leu Met 
                1205                1210                1215


Gln His Met Lys Leu Ser Thr Ser Arg Asp Phe Lys Ile Lys Gly Asn 
            1220                1225                1230


Ile Leu Asp Met Val Leu Arg Glu Asp Gly Glu Asp Glu Asn Glu Glu 
        1235                1240                1245


Gly Thr Ala Ser Glu His Gly Gly Gln Asn Lys Glu Pro Ala Lys Lys 
    1250                1255                1260


Lys Arg Lys Lys 
1265


<210>  1077
<211>  4465
<212>  DNA
<213>  Homo sapiens

<400>  1077
gcggaccggc cgggtggagg ccacacgcta ccccgaggct gcgtaggccg cgcgaagggg     60

gacgccgtgc cgtgggcctg gggtcggggg agcagcagac cgggaagcac cgtgaggacc    120

gaggatttgg ggtggaaggc aggcatggtc aaacccattt cactgacagg agagcagaga    180

caggacgtgt ctctctccac gtcttccagc cagtaaaaga agccaagctg gagcccaaag    240

ccaggtgttc tgactcccag cgtgggggtc cctgcaccaa ccatgagccg cctgctctgg    300

aggaaggtgg ccggcgccac cgtcgggcca gggccggttc cagctccggg gcgctgggtc    360

tccagctccg tccccgcgtc cgaccccagc gacgggcagc ggcggcggca gcagcagcag    420

cagcagcagc agcagcagca acagcagcct cagcagccgc aagtgctatc ctcggagggc    480

gggcagctgc ggcacaaccc attggacatc cagatgctct cgagagggct gcacgagcaa    540

atcttcgggc aaggagggga gatgcctggc gaggccgcgg tgcgccgcag cgtcgagcac    600

ctgcagaagc acgggctctg ggggcagcca gccgtgccct tgcccgacgt ggagctgcgc    660

ctgccgcccc tctacgggga caacctggac cagcacttcc gcctcctggc ccagaagcag    720

agcctgccct acctggaggc ggccaacttg ctgttgcagg cccagctgcc cccgaagccc    780

ccggcttggg cctgggcgga gggctggacc cggtacggcc ccgaggggga ggccgtaccc    840

gtggccatcc ccgaggagcg ggccctggtg ttcgacgtgg aggtctgctt ggcagaggga    900

acttgcccca cattggcggt ggccatatcc ccctcggcct ggtattcctg gtgcagccag    960

cggctggtgg aagagcgtta ctcttggacc agccagctgt cgccggctga cctcatcccc   1020

ctggaggtcc ctactggtgc cagcagcccc acccagagag actggcagga gcagttagtg   1080

gtggggcaca atgtttcctt tgaccgagct catatcaggg agcagtacct gatccagggt   1140

tcccgcatgc gtttcctgga caccatgagc atgcacatgg ccatctcagg gctaagcagc   1200

ttccagcgca gtctgtggat agcagccaag cagggcaaac acaaggtcca gccccccaca   1260

aagcaaggcc agaagtccca gaggaaagcc agaagaggcc cagcgatctc atcctgggac   1320

tggctggaca tcagcagtgt caacagtctg gcagaggtgc acagacttta tgtagggggg   1380

cctcccttag agaaggagcc tcgagaactg tttgtgaagg gcaccatgaa ggacattcgt   1440

gagaacttcc aggacctgat gcagtactgt gcccaggacg tgtgggccac ccatgaggtt   1500

ttccagcagc agctaccgct cttcttggag aggtgtcccc acccagtgac tctggccggc   1560

atgctggaga tgggtgtctc ctacctgcct gtcaaccaga actgggagcg ttacctggca   1620

gaggcacagg gcacttatga ggagctccag cgggagatga agaagtcgtt gatggatctg   1680

gccaatgatg cctgccagct gctctcagga gagaggtaca aagaagaccc ctggctctgg   1740

gacctggagt gggacctgca agaatttaag cagaagaaag ctaagaaggt gaagaaggaa   1800

ccagccacag ccagcaagtt gcccatcgag ggggctgggg cccctggtga tcccatggat   1860

caggaagacc tcggcccctg cagtgaggag gaggagtttc aacaagatgt catggcccgc   1920

gcctgcttgc agaagctgaa ggggaccaca gagctcctgc ccaagcggcc ccagcacctt   1980

cctggacacc ctggatggta ccggaagctc tgcccccggc tagacgaccc tgcatggacc   2040

ccgggcccca gcctcctcag cctgcagatg cgggtcacac ctaaactcat ggcacttacc   2100

tgggatggct tccctctgca ctactcagag cgtcatggct ggggctactt ggtgcctggg   2160

cggcgggaca acctggccaa gctgccgaca ggtaccaccc tggagtcagc tggggtggtc   2220

tgcccctaca gagccatcga gtccctgtac aggaagcact gtctcgaaca ggggaagcag   2280

cagctgatgc cccaggaggc cggcctggcg gaggagttcc tgctcactga caatagtgcc   2340

atatggcaaa cggtagaaga actggattac ttagaagtgg aggctgaggc caagatggag   2400

aacttgcgag ctgcagtgcc aggtcaaccc ctagctctga ctgcccgtgg tggccccaag   2460

gacacccagc ccagctatca ccatggcaat ggaccttaca acgacgtgga catccctggc   2520

tgctggtttt tcaagctgcc tcacaaggat ggtaatagct gtaatgtggg aagccccttt   2580

gccaaggact tcctgcccaa gatggaggat ggcaccctgc aggctggccc aggaggtgcc   2640

agtgggcccc gtgctctgga aatcaacaaa atgatttctt tctggaggaa cgcccataaa   2700

cgtatcagct cccagatggt ggtgtggctg cccaggtcag ctctgccccg tgctgtgatc   2760

aggcaccccg actatgatga ggaaggcctc tatggggcca tcctgcccca agtggtgact   2820

gccggcacca tcactcgccg ggctgtggag cccacatggc tcaccgccag caatgcccgg   2880

cctgaccgag taggcagtga gttgaaagcc atggtgcagg ccccacctgg ctacaccctt   2940

gtgggtgctg atgtggactc ccaagagctg tggattgcag ctgtgcttgg agacgcccac   3000

tttgccggca tgcatggctg cacagccttt gggtggatga cactgcaggg caggaagagc   3060

aggggcactg atctacacag taagacagcc actactgtgg gcatcagccg tgagcatgcc   3120

aaaatcttca actacggccg catctatggt gctgggcagc cctttgctga gcgcttacta   3180

atgcagttta accaccggct cacacagcag gaggcagctg agaaggccca gcagatgtac   3240

gctgccacca agggcctccg ctggtatcgg ctgtcggatg agggcgagtg gctggtgagg   3300

gagttgaacc tcccagtgga caggactgag ggtggctgga tttccctgca ggatctgcgc   3360

aaggtccaga gagaaactgc aaggaagtca cagtggaaga agtgggaggt ggttgctgaa   3420

cgggcatgga aggggggcac agagtcagaa atgttcaata agcttgagag cattgctacg   3480

tctgacatac cacgtacccc ggtgctgggc tgctgcatca gccgagccct ggagccctcg   3540

gctgtccagg aagagtttat gaccagccgt gtgaattggg tggtacagag ctctgctgtt   3600

gactacttac acctcatgct tgtggccatg aagtggctgt ttgaagagtt tgccatagat   3660

gggcgcttct gcatcagcat ccatgacgag gttcgctacc tggtgcggga ggaggaccgc   3720

taccgcgctg ccctggcctt gcagatcacc aacctcttga ccaggtgcat gtttgcctac   3780

aagctgggtc tgaatgactt gccccagtca gtcgcctttt tcagtgcagt cgatattgac   3840

cggtgcctca ggaaggaagt gaccatggat tgtaaaaccc cttccaaccc aactgggatg   3900

gaaaggagat acgggattcc ccagggtgaa gcgctggata tttaccagat aattgaactc   3960

accaaaggct ccttggaaaa acgaagccag cctggaccat agcactgcct ggaggctctg   4020

tatttgctcc cgtggagctt catcggggtg gtgcaggctc ccaaactcag gctttcagct   4080

gtgctttttg caaaagggct tgcctaaggc cagccatttt tcagtagcag gacctgccaa   4140

gaagattcct tctaactgaa ggtgcagttg aattcagtgg gttcagaacc aagatgccaa   4200

catcggtgtg gactacagga caaggggcat tgttgcttgt tgggtaaaaa tgaagcagaa   4260

gccccaaagt tcacattaac tcaggcattt catttatttt ttccttttct tcttggctgg   4320

ttctttgttc tgtcccccat gctctgatgc agtgccctag aaggggaaag aattaatgct   4380

ctaacgtgat aaacctgctc caaggcagtg gaaataaaaa gaaggaaaaa aaagaaaaaa   4440

aaaaaaaaaa aaaaaaaaaa aaaat                                         4465


<210>  1078
<211>  1239
<212>  PRT
<213>  Homo sapiens

<400>  1078

Met Ser Arg Leu Leu Trp Arg Lys Val Ala Gly Ala Thr Val Gly Pro 
1               5                   10                  15


Gly Pro Val Pro Ala Pro Gly Arg Trp Val Ser Ser Ser Val Pro Ala 
            20                  25                  30


Ser Asp Pro Ser Asp Gly Gln Arg Arg Arg Gln Gln Gln Gln Gln Gln 
        35                  40                  45


Gln Gln Gln Gln Gln Gln Gln Pro Gln Gln Pro Gln Val Leu Ser Ser 
    50                  55                  60


Glu Gly Gly Gln Leu Arg His Asn Pro Leu Asp Ile Gln Met Leu Ser 
65                  70                  75                  80


Arg Gly Leu His Glu Gln Ile Phe Gly Gln Gly Gly Glu Met Pro Gly 
                85                  90                  95


Glu Ala Ala Val Arg Arg Ser Val Glu His Leu Gln Lys His Gly Leu 
            100                 105                 110


Trp Gly Gln Pro Ala Val Pro Leu Pro Asp Val Glu Leu Arg Leu Pro 
        115                 120                 125


Pro Leu Tyr Gly Asp Asn Leu Asp Gln His Phe Arg Leu Leu Ala Gln 
    130                 135                 140


Lys Gln Ser Leu Pro Tyr Leu Glu Ala Ala Asn Leu Leu Leu Gln Ala 
145                 150                 155                 160


Gln Leu Pro Pro Lys Pro Pro Ala Trp Ala Trp Ala Glu Gly Trp Thr 
                165                 170                 175


Arg Tyr Gly Pro Glu Gly Glu Ala Val Pro Val Ala Ile Pro Glu Glu 
            180                 185                 190


Arg Ala Leu Val Phe Asp Val Glu Val Cys Leu Ala Glu Gly Thr Cys 
        195                 200                 205


Pro Thr Leu Ala Val Ala Ile Ser Pro Ser Ala Trp Tyr Ser Trp Cys 
    210                 215                 220


Ser Gln Arg Leu Val Glu Glu Arg Tyr Ser Trp Thr Ser Gln Leu Ser 
225                 230                 235                 240


Pro Ala Asp Leu Ile Pro Leu Glu Val Pro Thr Gly Ala Ser Ser Pro 
                245                 250                 255


Thr Gln Arg Asp Trp Gln Glu Gln Leu Val Val Gly His Asn Val Ser 
            260                 265                 270


Phe Asp Arg Ala His Ile Arg Glu Gln Tyr Leu Ile Gln Gly Ser Arg 
        275                 280                 285


Met Arg Phe Leu Asp Thr Met Ser Met His Met Ala Ile Ser Gly Leu 
    290                 295                 300


Ser Ser Phe Gln Arg Ser Leu Trp Ile Ala Ala Lys Gln Gly Lys His 
305                 310                 315                 320


Lys Val Gln Pro Pro Thr Lys Gln Gly Gln Lys Ser Gln Arg Lys Ala 
                325                 330                 335


Arg Arg Gly Pro Ala Ile Ser Ser Trp Asp Trp Leu Asp Ile Ser Ser 
            340                 345                 350


Val Asn Ser Leu Ala Glu Val His Arg Leu Tyr Val Gly Gly Pro Pro 
        355                 360                 365


Leu Glu Lys Glu Pro Arg Glu Leu Phe Val Lys Gly Thr Met Lys Asp 
    370                 375                 380


Ile Arg Glu Asn Phe Gln Asp Leu Met Gln Tyr Cys Ala Gln Asp Val 
385                 390                 395                 400


Trp Ala Thr His Glu Val Phe Gln Gln Gln Leu Pro Leu Phe Leu Glu 
                405                 410                 415


Arg Cys Pro His Pro Val Thr Leu Ala Gly Met Leu Glu Met Gly Val 
            420                 425                 430


Ser Tyr Leu Pro Val Asn Gln Asn Trp Glu Arg Tyr Leu Ala Glu Ala 
        435                 440                 445


Gln Gly Thr Tyr Glu Glu Leu Gln Arg Glu Met Lys Lys Ser Leu Met 
    450                 455                 460


Asp Leu Ala Asn Asp Ala Cys Gln Leu Leu Ser Gly Glu Arg Tyr Lys 
465                 470                 475                 480


Glu Asp Pro Trp Leu Trp Asp Leu Glu Trp Asp Leu Gln Glu Phe Lys 
                485                 490                 495


Gln Lys Lys Ala Lys Lys Val Lys Lys Glu Pro Ala Thr Ala Ser Lys 
            500                 505                 510


Leu Pro Ile Glu Gly Ala Gly Ala Pro Gly Asp Pro Met Asp Gln Glu 
        515                 520                 525


Asp Leu Gly Pro Cys Ser Glu Glu Glu Glu Phe Gln Gln Asp Val Met 
    530                 535                 540


Ala Arg Ala Cys Leu Gln Lys Leu Lys Gly Thr Thr Glu Leu Leu Pro 
545                 550                 555                 560


Lys Arg Pro Gln His Leu Pro Gly His Pro Gly Trp Tyr Arg Lys Leu 
                565                 570                 575


Cys Pro Arg Leu Asp Asp Pro Ala Trp Thr Pro Gly Pro Ser Leu Leu 
            580                 585                 590


Ser Leu Gln Met Arg Val Thr Pro Lys Leu Met Ala Leu Thr Trp Asp 
        595                 600                 605


Gly Phe Pro Leu His Tyr Ser Glu Arg His Gly Trp Gly Tyr Leu Val 
    610                 615                 620


Pro Gly Arg Arg Asp Asn Leu Ala Lys Leu Pro Thr Gly Thr Thr Leu 
625                 630                 635                 640


Glu Ser Ala Gly Val Val Cys Pro Tyr Arg Ala Ile Glu Ser Leu Tyr 
                645                 650                 655


Arg Lys His Cys Leu Glu Gln Gly Lys Gln Gln Leu Met Pro Gln Glu 
            660                 665                 670


Ala Gly Leu Ala Glu Glu Phe Leu Leu Thr Asp Asn Ser Ala Ile Trp 
        675                 680                 685


Gln Thr Val Glu Glu Leu Asp Tyr Leu Glu Val Glu Ala Glu Ala Lys 
    690                 695                 700


Met Glu Asn Leu Arg Ala Ala Val Pro Gly Gln Pro Leu Ala Leu Thr 
705                 710                 715                 720


Ala Arg Gly Gly Pro Lys Asp Thr Gln Pro Ser Tyr His His Gly Asn 
                725                 730                 735


Gly Pro Tyr Asn Asp Val Asp Ile Pro Gly Cys Trp Phe Phe Lys Leu 
            740                 745                 750


Pro His Lys Asp Gly Asn Ser Cys Asn Val Gly Ser Pro Phe Ala Lys 
        755                 760                 765


Asp Phe Leu Pro Lys Met Glu Asp Gly Thr Leu Gln Ala Gly Pro Gly 
    770                 775                 780


Gly Ala Ser Gly Pro Arg Ala Leu Glu Ile Asn Lys Met Ile Ser Phe 
785                 790                 795                 800


Trp Arg Asn Ala His Lys Arg Ile Ser Ser Gln Met Val Val Trp Leu 
                805                 810                 815


Pro Arg Ser Ala Leu Pro Arg Ala Val Ile Arg His Pro Asp Tyr Asp 
            820                 825                 830


Glu Glu Gly Leu Tyr Gly Ala Ile Leu Pro Gln Val Val Thr Ala Gly 
        835                 840                 845


Thr Ile Thr Arg Arg Ala Val Glu Pro Thr Trp Leu Thr Ala Ser Asn 
    850                 855                 860


Ala Arg Pro Asp Arg Val Gly Ser Glu Leu Lys Ala Met Val Gln Ala 
865                 870                 875                 880


Pro Pro Gly Tyr Thr Leu Val Gly Ala Asp Val Asp Ser Gln Glu Leu 
                885                 890                 895


Trp Ile Ala Ala Val Leu Gly Asp Ala His Phe Ala Gly Met His Gly 
            900                 905                 910


Cys Thr Ala Phe Gly Trp Met Thr Leu Gln Gly Arg Lys Ser Arg Gly 
        915                 920                 925


Thr Asp Leu His Ser Lys Thr Ala Thr Thr Val Gly Ile Ser Arg Glu 
    930                 935                 940


His Ala Lys Ile Phe Asn Tyr Gly Arg Ile Tyr Gly Ala Gly Gln Pro 
945                 950                 955                 960


Phe Ala Glu Arg Leu Leu Met Gln Phe Asn His Arg Leu Thr Gln Gln 
                965                 970                 975


Glu Ala Ala Glu Lys Ala Gln Gln Met Tyr Ala Ala Thr Lys Gly Leu 
            980                 985                 990


Arg Trp Tyr Arg Leu Ser Asp Glu Gly Glu Trp Leu Val Arg Glu Leu 
        995                 1000                1005


Asn Leu Pro Val Asp Arg Thr Glu Gly Gly Trp Ile Ser Leu Gln Asp 
    1010                1015                1020


Leu Arg Lys Val Gln Arg Glu Thr Ala Arg Lys Ser Gln Trp Lys Lys 
1025                1030                1035                1040


Trp Glu Val Val Ala Glu Arg Ala Trp Lys Gly Gly Thr Glu Ser Glu 
                1045                1050                1055


Met Phe Asn Lys Leu Glu Ser Ile Ala Thr Ser Asp Ile Pro Arg Thr 
            1060                1065                1070


Pro Val Leu Gly Cys Cys Ile Ser Arg Ala Leu Glu Pro Ser Ala Val 
        1075                1080                1085


Gln Glu Glu Phe Met Thr Ser Arg Val Asn Trp Val Val Gln Ser Ser 
    1090                1095                1100


Ala Val Asp Tyr Leu His Leu Met Leu Val Ala Met Lys Trp Leu Phe 
1105                1110                1115                1120


Glu Glu Phe Ala Ile Asp Gly Arg Phe Cys Ile Ser Ile His Asp Glu 
                1125                1130                1135


Val Arg Tyr Leu Val Arg Glu Glu Asp Arg Tyr Arg Ala Ala Leu Ala 
            1140                1145                1150


Leu Gln Ile Thr Asn Leu Leu Thr Arg Cys Met Phe Ala Tyr Lys Leu 
        1155                1160                1165


Gly Leu Asn Asp Leu Pro Gln Ser Val Ala Phe Phe Ser Ala Val Asp 
    1170                1175                1180


Ile Asp Arg Cys Leu Arg Lys Glu Val Thr Met Asp Cys Lys Thr Pro 
1185                1190                1195                1200


Ser Asn Pro Thr Gly Met Glu Arg Arg Tyr Gly Ile Pro Gln Gly Glu 
                1205                1210                1215


Ala Leu Asp Ile Tyr Gln Ile Ile Glu Leu Thr Lys Gly Ser Leu Glu 
            1220                1225                1230


Lys Arg Ser Gln Pro Gly Pro 
        1235


<210>  1079
<211>  2032
<212>  DNA
<213>  Homo sapiens

<400>  1079
gtgcatccct gccccttctg ggtacccgta ggcgctcccg ggcgctggcg gcggcggagg     60

agagggagca gcgtcacggg cgcccggccc gttaaaacgc tgctggctgg agccacctcc    120

ctccctgcag cccgcaacgg gaatggagta aagggagacc cgtcgacctg gccacgggga    180

tcagcgatgg aattaaagca atctttgtcc acccatctgg aagccgagaa gcctctgagg    240

cgctatgggg cggtggagga gacggcttgg aaaacggaga gactggggag aaatcagctg    300

gacatcatct ccatggcgga gacaaccatg atgccagagg agattgagct ggagatggca    360

aaaattcagc gtctccggga agtcttggtc cgccgggagt ctgagctcag gttcatgatg    420

gatgacatcc agctctgcaa ggacatcatg gacttgaagc aggagctgca gaacttggtc    480

gccatcccag aaaaagaaaa aaccaaactg cagaagcaga gagaggatga gctaatccag    540

aagatccaca aactggtgca gaagagagac ttcctggtgg acgatgcgga ggtcgagcgg    600

ttaagggagc aagaagaaga caaggaaatg gctgatttcc tgagaatcaa gttaaaacct    660

ctagacaaag taaccaaatc tccagccagc tcccgggcag agaagaaagc agagccccca    720

cctagcaagc ccacggtggc caagacgggg ctggcactga tcaaggattg ttgcggggcc    780

acccagtgca acatcatgta gcccccacgt ggggtgccct gggccatggg gacccccccc    840

ccaccctctt gtctttatag cccccatttc accggggccc aagagctctc caaggcagaa    900

ggggttgaag gcaagcccgt gactgtcacc agaggccatg ggcacggcag gcgggcctgg    960

ccaccctgta cagagtgtag cagtagggag tctctcaccg tcgcatggtc ctccccagag   1020

catgccgaac ccaggagtct gtctcactgt ttatccaaac accaggaaag gtcctccctc   1080

aaaaaagcat atctccactt ctctctagct gtatctaacc caccgtgtga atgaactggg   1140

agaggggcat gctccccagc tgtgtgtagt cgtgacttct caacaatcta gcaccatgtc   1200

ggacacgttc cccatccacc ctcctagctc tgctctcaga gctaggcaca tgggcacagg   1260

tcccctcccg tctgtcctct cccagcaact gtgccctgga gggctccaca tggcccccgt   1320

gtctctcggg caccacccat atagcagtcc cagagggccc atctgtaaag atcgagcttg   1380

tgtgtggtgt cgtggtcaca tctcccgctt ccccccatcc tgtgtctggg cacagttcac   1440

atcaggacag cgtccattgt gctctcagtc tgcctcaggt gtgtgcctgg agggggcctg   1500

gactggcatg gatccagtgt gcagaagagc cagcagggaa ccggaagctc tgatgtcaag   1560

gccagagcag ttgagaatgg gacccagagt agatgctgac ctgggcactc caccattccg   1620

gggcaccaca gagatgccag caggatgcca ctttgccagc ccgacacacg gacctttgta   1680

aagaacagca acaggcagga gaggcagcgt gtgaccagat tgtgtcccgt cattgggtgg   1740

catatgttaa ctagctgcca aacaacttca acccgtgtaa ttcatgtaca tttgcaacag   1800

ccagcccggt acagcctgtg tgacttctct gtatgtgtgt gtgtgtcgtg accagcctaa   1860

gtagttagca taactcaaga tgctgatgtg cagtcaccca tcagagaaaa taaaaatgga   1920

aaccacgttc acagcatttt aaaagttttt actttttttc ttgattatgg aagtaatcca   1980

tgtacatagt aaatcatttt aaaagtacaa aaagtatgaa gaagtttgtc tt           2032


<210>  1080
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  1080

Met Glu Leu Lys Gln Ser Leu Ser Thr His Leu Glu Ala Glu Lys Pro 
1               5                   10                  15


Leu Arg Arg Tyr Gly Ala Val Glu Glu Thr Ala Trp Lys Thr Glu Arg 
            20                  25                  30


Leu Gly Arg Asn Gln Leu Asp Ile Ile Ser Met Ala Glu Thr Thr Met 
        35                  40                  45


Met Pro Glu Glu Ile Glu Leu Glu Met Ala Lys Ile Gln Arg Leu Arg 
    50                  55                  60


Glu Val Leu Val Arg Arg Glu Ser Glu Leu Arg Phe Met Met Asp Asp 
65                  70                  75                  80


Ile Gln Leu Cys Lys Asp Ile Met Asp Leu Lys Gln Glu Leu Gln Asn 
                85                  90                  95


Leu Val Ala Ile Pro Glu Lys Glu Lys Thr Lys Leu Gln Lys Gln Arg 
            100                 105                 110


Glu Asp Glu Leu Ile Gln Lys Ile His Lys Leu Val Gln Lys Arg Asp 
        115                 120                 125


Phe Leu Val Asp Asp Ala Glu Val Glu Arg Leu Arg Glu Gln Glu Glu 
    130                 135                 140


Asp Lys Glu Met Ala Asp Phe Leu Arg Ile Lys Leu Lys Pro Leu Asp 
145                 150                 155                 160


Lys Val Thr Lys Ser Pro Ala Ser Ser Arg Ala Glu Lys Lys Ala Glu 
                165                 170                 175


Pro Pro Pro Ser Lys Pro Thr Val Ala Lys Thr Gly Leu Ala Leu Ile 
            180                 185                 190


Lys Asp Cys Cys Gly Ala Thr Gln Cys Asn Ile Met 
        195                 200


<210>  1081
<211>  7745
<212>  DNA
<213>  Homo sapiens

<400>  1081
ggaagcggaa gtgaagggtg cgcttggcgg cggcggcggg agctgcggag tcgggaatca     60

aaacaaaggg cctggggggg gcggggggaa ggcggcgggg ccggaatgtg agcggaggtg    120

gagccggcgg cagagggtgg aagaatgaaa gaaaagaaag atgaaaggat gttgaatcac    180

tttgcatggc tgtatgatgg aaggaaacgg aactgagaac tcctgcagta gaacacgtgg    240

atggcttcaa caagataatg atgctaagcc atggctttgg aaattctcta attgcttttc    300

tcgtcctgag cagacgctgc cacatagtcc ccaaacgaaa gagtacatgg agaacaagaa    360

agttgctgtg gaactaaagg atgtaccatc accccttcat gctggctcta agctttttcc    420

agcagtccca cttcctgata ttcgttctct tcagcagcct aaaatacagc tttcttctgt    480

ccccaaagta agctgctgtg ctcattgccc taatgaaccc tccacttcgc caatgcgttt    540

tggtggtggt ggtggcggta gcggaggtac cagtagcttg attcacccgg gcgcactgtt    600

agactcgcaa agcaccagga caatcacgtg tcaggtaggg tcagggtttg ctttccagtc    660

tgcatcttca ctccagaatg cctcagctag gaacaatttg gcaggcattg caagtgactt    720

tcccagcatg tgtctagaga gtaacctgtc ttcctgcaaa cacctgccct gttgtggaaa    780

actccacttc cagtcatgtc atggtaatgt gcacaagctg catcagtttc cgagtctgca    840

gggctgcacc tccgctggct atttcccctg ttctgatttc acaagcgggg ctccagggca    900

tttggaagag cacatttcac agtcggagct aacgcctcac ttgtgcacca actctttgca    960

ccttaatgtg gtacctccgg tttgtttaaa gggctcactt tactgcgaag actgtctaaa   1020

caagccagca agaaatagca taatcgatgc ggctaaagtc tggccaaata taccacctcc   1080

aaatactcaa cctgcacctc ttgctgtccc tctgtgtaat ggctgtggaa ccaaaggaac   1140

agggaaggag accacgttgt tattggcgac cagtctaggc aaagctgctt caaaatttgg   1200

gtcaccagaa gttgcagtag ctggacaggt gctagaaaac ttacccccca ttggagtttt   1260

ttgggatatt gaaaactgct ccgttccctc tggccggtca gcaactgctg ttgtgcaaag   1320

aatccgtgag aagtttttta aaggccacag agaagcagaa ttcatctgtg tatgtgacat   1380

cagtaaagaa aacaaggaag ttattcaaga gctgaataat tgccaggtaa ccgttgccca   1440

catcaatgct actgcaaaga atgccgctga tgataaactg cggcagagtc tccgcagatt   1500

tgcaaataca cacactgctc cagccacagt ggttcttgtg tcaactgatg tcaattttgc   1560

attggaactt agtgacctga gacacaggca tggtttccac attattttgg tccataaaaa   1620

ccaggcctca gaagcactgc tgcatcatgc taacgagctg atcagatttg aagagttcat   1680

ttccgacttg ccccccaggt taccactaaa aatgccacag tgccacactc tgctctatgt   1740

ttataaccta ccagcaaata aggatggcaa gagcgtcagc aacaggctca gacgcctgtc   1800

cgataattgt ggtgggaaag tgctgagtat cacaggctgc agtgcaattc tccgcttcat   1860

aaaccaagat agtgcagagc gcgctcagaa gcgaatggaa aacgaagatg tctttggtaa   1920

taggatcatt gtgtcattta ctccaaaaaa tagagaactc tgtgaaacaa agagttcaaa   1980

tgcaattgct gataaagtga agtctcccaa aaaacttaag aatccaaaat tgtgcctcat   2040

caaagatgca agtgaacaat cttccagtgc caaagccacg cctggaaaag ggtcacaggc   2100

aaattctgga tctgctacaa aaaatacaaa tgttaaaagt ttacaggagc tgtgccgcat   2160

ggagtcaaaa actggtcata gaaacagtga gcaccagcaa ggtcacctga ggctggtcgt   2220

acccactcac ggtaactcaa gtgctgcagt gtcgacgccg aaaaactcgg gggtggcaga   2280

acccgtttac aaaaccagtc agaaaaagga gaacctcagt gcccgaagtg ttaccagttc   2340

tcctgtagag aaaaaagata aagaggagac tgtattccaa gtgagttacc cgtctgcttt   2400

tagcaagtta gttgcatcca ggcaagtcag tcctctgctc gcatctcagt cttggtcttc   2460

taggagtatg tctccaaacc ttttaaacag agcatccccg cttgctttca acattgcaaa   2520

ttcgagcagc gaagccgact gcccagaccc atttgcaaat ggtgctgatg tccaagtcag   2580

caacatagac tacagattat cccggaagga gctgcagcag ctcctgcagg aagcatttgc   2640

caggcatggc aaggtgaaga gtgttgagct cagcccccat acagattatc aactcaaggc   2700

tgttgtgcaa atggaaaact tacaagatgc gatcggtgca gtgaatagcc tccacagata   2760

caaaattggc agcaaaaaga tcctggtctc acttgccacc ggggctgcca gcaaatcact   2820

ctctttactg agtgcagaaa caatgtctgt tcttcaggat gcccctgcct gttgcctgcc   2880

tctgtttaaa tttacagata tctatgaaaa aaagtttgga cacaagttga atgtgtcaga   2940

tctatataaa ttaacagaca cggtcgcaat ccgtgaacaa ggaaacggac ggctggtgtg   3000

tctcctaccc agcagtcagg cccgccagag ccccttgggg tcttcccagt cacacgacgg   3060

ctcctccacg aattgcagcc caattatatt tgaagagtta gaatatcacg agcctgtctg   3120

cagacagcat tgttccaata aggatttcag cgaacatgaa tttgatccag actcttacaa   3180

gattcctttt gtgattcttt ctttgaagac atttgcgccc caggttcaca gtcttctcca   3240

gacccacgag ggcaccgtgc ctttattgag ctttccagat tgttacattg cagagtttgg   3300

cgatctagaa gtagtgcaag aaaaccaagg aggtgttccc ttagaacact tcattacctg   3360

tgttccaggt gtaaacattg ccactgctca gaatggcatc aaagtggtta aatggattca   3420

caacaagccc ccgcctccca acactgaccc ttggcttctg cgttcgaaga gtcctgtagg   3480

taacccccag ctgatccagt tcagtagaga agtgattgac ttgctgaaaa gccagccatc   3540

ttgtgtcata cccatcagtc atttcatccc atcctatcac catcattttg caaagcagtg   3600

ccgagtgtca gactacggat actccaagct gattgagtta ttagaagcag tgcctcatgt   3660

attgcagatt cttggaatgg gctccaaacg tctgctgacc cttacccaca gggcccaggt   3720

gaagcgcttt actcaggatt tactaaaact tctcaaatcc caggccagca aacaggtcat   3780

tgtgagagaa ttctcacagg cttatcactg gtgtttctca aaggactggg atgtcactga   3840

atatggtgtt tgtgagttga ttgacatcgt atcagagatt ccagacacaa ccatctgctt   3900

gtcccaacaa gataatgaaa tggtgatttg tatccccaaa agagaacgca ctcaggatga   3960

aatagaaagg acaaaacagt tctccaagga tgtcgttgat ttgctgcgtc accaacccca   4020

tttccggatg ccctttaata aatttatccc ttcttaccat caccactttg gccggcagtg   4080

caaacttgcg tactatgggt ttaccaaact acttgaactt tttgaagcca tacctgatac   4140

tttacaagta ttggaatgtg gagaagaaaa gatccttact ctgacagagg tggagcggtt   4200

caaagctcta gctgcccagt ttgttaaact ccttcggtcc caaaaagata actgccttat   4260

gatgacagat ctccttacag aatatgctaa aacttttggt tatacatttc gtctccaaga   4320

ctatgatgtc agttccattt cggctttaac tcagaaactc tgccatgtcg tgaaggttgc   4380

cgatatagaa tctggcagac agattcagct gatcaaccga aagtctctgc gatctctcac   4440

tgcccagttg ctggtattgt tgatgtcttg ggaaggaacc acccatcttt ctgttgagga   4500

gctcaagaga cattacgaaa gtacccacaa cactcccctt aacccctgtg aatatggatt   4560

catgaccttg accgaactgc tgaagagcct gccatacttg gttgaggttt tcactaatga   4620

taagatggaa gaatgtgtga agctcacaag tctgtatttg tttgcaaaga atgtgcggtc   4680

tttacttcat acttaccact accagcagat tttccttcat gagttttcca tggcctatac   4740

caagtatgtc ggagaaactc tgcagcccaa gacctacggc cacagcagcg tggaggagct   4800

cttgggagca attccacagg tggtctggat aaaaggacat ggtcataaga gaattgtagt   4860

gttaaaaaat gacatgaaaa gtcgtttgag ttcactcagt ctctcccctg ccaatcatga   4920

aaaccagccc tcggagggcg agcgcatcct ggaggtgccc gaatcgcaca cagcctcgga   4980

actcaagctt ggagctgacg gcagtgggcc cagtcacaca gagcaggagc ttctccgcct   5040

gaccgacgac tcccccgtcg acctcctgtg tgcgcctgtc ccctcgtgcc tgccgtcccc   5100

tcagctgaga ccagaccccg ttatcctcca atctgctgat ctcattcagt ttgaggagcg   5160

ccctcaagag ccttctgaaa ttatgatttt aaaccaagaa gaaaaaatgg agattccaat   5220

accaggaaag agcaaaactc tgacctctga ctccagctcg tcctgcatct cagcagctgt   5280

ccccgtgcct ccctgcccct cctcggaaac ctccgagtca ctgctcagca aggaccccgt   5340

ggaaagcccg gccaaaaagc aacccaaaaa tagagtcaaa ttggcagcca acttttcctt   5400

agcacctata accaagcttt aactcccatt tggaatatag aattaggatg ggaaaacact   5460

gtctgattct gcacacaaaa gtgggtttca aaaatacatc cttttctgtg tcatgaaaac   5520

cccccgaagc cattgacttc atcttacctg tgttctatca tgtttttctt ttccattgaa   5580

cacagctttg agctgaagtc tttcttttct tcttcctttt tctttctttt ttcaattatt   5640

tgaagaactt gtggcatttg ttaaagaatc cttaatatat tttaccaaat ttttagtaac   5700

tattatgaaa tacaatggtg ttccaaaaga agaaagcact aaaaactcaa ctagcaggaa   5760

gcggttttgc ttccattgag ccacgtcggt ggtgtcatcc tacatgtagc ataatagagt   5820

ctctcagcct ttgcttactg gtgtttccga cagtattaac ccagtgcgtg gcatgtcttt   5880

gaagcaaagc ctgtcccgct agcctgtgtg ttcacacacc aaaggagaag ggtaggcgag   5940

gggttcggag tgtattttca ggttggaatg tgaaggttcc tggcttccat gtgacttgta   6000

agtgtgcctt gttttttatt taaactatgt ctgtagttga caaaagtggc ttcatcacaa   6060

atttttttaa acgtttctac tttggggttc catttaggag ctttctagaa agttgaggat   6120

gtttgaagct tcccttctgt gttccagttt gatatgggtt aggttaagga aaaggagatg   6180

gtctcgatgt catggattta aagtcagcat ttggattaca acacacatta ttgtgtgtcg   6240

agaggcagca ttggaaagag cctgattttc taaaatatgc atcaagtgca taaattacaa   6300

atcagagctg agtggggagg tgcttcagca gcagcgggat caatacgatt tccactggga   6360

agagacagga attctaccta cacataggaa ggccaaggtt gatccactta accttgttat   6420

tgtaatttta aagctggtat cggtagctgg gaagctttat gtgtgtgtat gtcagctcag   6480

catcttttaa tcgtgtctga ttttactctc gttacttctc gctgttggaa gcatctctgg   6540

gtttcttgtg gcgtctggtg tggaatggcc ttcctctcta ggtgcctgag gtgtccgctg   6600

acgggtggcc tctcaccccc ctctagagaa acctgacatt tacaatggat tgtatttgtc   6660

cggcaaaaaa ggcggattca ttcatagagc agaaagaacc tgttggcgta aggtcttcca   6720

ctagttagat ggtttctttt ggggaaatgt ttatatttgg taacttctag aaagccagaa   6780

aatggactct gatttcatag cattttgata aaatgccaca aaataagggc tatagagaga   6840

tttttacaag tcagattttt tgttccccaa atcttttaaa tgaagccagt gactcccagt   6900

tctcaacaca tggccccagt caagacagaa caccatggaa aaaaccctgt aagtattatg   6960

gcactctccg aatcctcctg aaggcatttc ctctacagac atagtgttac aggaagtgaa   7020

atgcaaatgt gcaatttttt ttaaaggagc ttttaaacaa agtaataata attggtgttg   7080

agaacatcag ttgccttatt ctaagatttc ataaggctga gtttgcacgc ttggacttca   7140

gttctgctag catgtaaaga gtggtggact ttaaaaccgt aagaggtatc attacaagtc   7200

acctggaaca gactcaaaga acaggttctt tgggcaacag acaaagaaga atcaagttct   7260

gtgctgtccc gtgagtgtgt ctgagtacca ttcactggag ttgctgctta ggtctgggac   7320

gtgtgtgtga ctcttaacaa ttgctgtctg aaaatgagag agaagacttc ggaagcacat   7380

tgtgttcata atgtactcca caatggccag tccaattgct atctattttt ttatccagag   7440

gcttaattaa atgatgtggt aaaatgatgt ttgagcatta agacaatgta attctttatt   7500

tctgggtgga aagatatacc ggattaaatt tatctgttta aaaaaatgac aaaagttatc   7560

accaaaaccc cctttcccat cttgcactgt ttgttttgga ttgggtttgg gggaaagaga   7620

tgtttttctt agttgtctac tttgtttgaa cacttttgtt gtggttcaag tgctgttttg   7680

tgtgttggga ccaaacagtt gtcaataaac tttacaagcg agcatctaaa aaaaaaaaaa   7740

aaaaa                                                               7745


<210>  1082
<211>  1742
<212>  PRT
<213>  Homo sapiens

<400>  1082

Met Met Glu Gly Asn Gly Thr Glu Asn Ser Cys Ser Arg Thr Arg Gly 
1               5                   10                  15


Trp Leu Gln Gln Asp Asn Asp Ala Lys Pro Trp Leu Trp Lys Phe Ser 
            20                  25                  30


Asn Cys Phe Ser Arg Pro Glu Gln Thr Leu Pro His Ser Pro Gln Thr 
        35                  40                  45


Lys Glu Tyr Met Glu Asn Lys Lys Val Ala Val Glu Leu Lys Asp Val 
    50                  55                  60


Pro Ser Pro Leu His Ala Gly Ser Lys Leu Phe Pro Ala Val Pro Leu 
65                  70                  75                  80


Pro Asp Ile Arg Ser Leu Gln Gln Pro Lys Ile Gln Leu Ser Ser Val 
                85                  90                  95


Pro Lys Val Ser Cys Cys Ala His Cys Pro Asn Glu Pro Ser Thr Ser 
            100                 105                 110


Pro Met Arg Phe Gly Gly Gly Gly Gly Gly Ser Gly Gly Thr Ser Ser 
        115                 120                 125


Leu Ile His Pro Gly Ala Leu Leu Asp Ser Gln Ser Thr Arg Thr Ile 
    130                 135                 140


Thr Cys Gln Val Gly Ser Gly Phe Ala Phe Gln Ser Ala Ser Ser Leu 
145                 150                 155                 160


Gln Asn Ala Ser Ala Arg Asn Asn Leu Ala Gly Ile Ala Ser Asp Phe 
                165                 170                 175


Pro Ser Met Cys Leu Glu Ser Asn Leu Ser Ser Cys Lys His Leu Pro 
            180                 185                 190


Cys Cys Gly Lys Leu His Phe Gln Ser Cys His Gly Asn Val His Lys 
        195                 200                 205


Leu His Gln Phe Pro Ser Leu Gln Gly Cys Thr Ser Ala Gly Tyr Phe 
    210                 215                 220


Pro Cys Ser Asp Phe Thr Ser Gly Ala Pro Gly His Leu Glu Glu His 
225                 230                 235                 240


Ile Ser Gln Ser Glu Leu Thr Pro His Leu Cys Thr Asn Ser Leu His 
                245                 250                 255


Leu Asn Val Val Pro Pro Val Cys Leu Lys Gly Ser Leu Tyr Cys Glu 
            260                 265                 270


Asp Cys Leu Asn Lys Pro Ala Arg Asn Ser Ile Ile Asp Ala Ala Lys 
        275                 280                 285


Val Trp Pro Asn Ile Pro Pro Pro Asn Thr Gln Pro Ala Pro Leu Ala 
    290                 295                 300


Val Pro Leu Cys Asn Gly Cys Gly Thr Lys Gly Thr Gly Lys Glu Thr 
305                 310                 315                 320


Thr Leu Leu Leu Ala Thr Ser Leu Gly Lys Ala Ala Ser Lys Phe Gly 
                325                 330                 335


Ser Pro Glu Val Ala Val Ala Gly Gln Val Leu Glu Asn Leu Pro Pro 
            340                 345                 350


Ile Gly Val Phe Trp Asp Ile Glu Asn Cys Ser Val Pro Ser Gly Arg 
        355                 360                 365


Ser Ala Thr Ala Val Val Gln Arg Ile Arg Glu Lys Phe Phe Lys Gly 
    370                 375                 380


His Arg Glu Ala Glu Phe Ile Cys Val Cys Asp Ile Ser Lys Glu Asn 
385                 390                 395                 400


Lys Glu Val Ile Gln Glu Leu Asn Asn Cys Gln Val Thr Val Ala His 
                405                 410                 415


Ile Asn Ala Thr Ala Lys Asn Ala Ala Asp Asp Lys Leu Arg Gln Ser 
            420                 425                 430


Leu Arg Arg Phe Ala Asn Thr His Thr Ala Pro Ala Thr Val Val Leu 
        435                 440                 445


Val Ser Thr Asp Val Asn Phe Ala Leu Glu Leu Ser Asp Leu Arg His 
    450                 455                 460


Arg His Gly Phe His Ile Ile Leu Val His Lys Asn Gln Ala Ser Glu 
465                 470                 475                 480


Ala Leu Leu His His Ala Asn Glu Leu Ile Arg Phe Glu Glu Phe Ile 
                485                 490                 495


Ser Asp Leu Pro Pro Arg Leu Pro Leu Lys Met Pro Gln Cys His Thr 
            500                 505                 510


Leu Leu Tyr Val Tyr Asn Leu Pro Ala Asn Lys Asp Gly Lys Ser Val 
        515                 520                 525


Ser Asn Arg Leu Arg Arg Leu Ser Asp Asn Cys Gly Gly Lys Val Leu 
    530                 535                 540


Ser Ile Thr Gly Cys Ser Ala Ile Leu Arg Phe Ile Asn Gln Asp Ser 
545                 550                 555                 560


Ala Glu Arg Ala Gln Lys Arg Met Glu Asn Glu Asp Val Phe Gly Asn 
                565                 570                 575


Arg Ile Ile Val Ser Phe Thr Pro Lys Asn Arg Glu Leu Cys Glu Thr 
            580                 585                 590


Lys Ser Ser Asn Ala Ile Ala Asp Lys Val Lys Ser Pro Lys Lys Leu 
        595                 600                 605


Lys Asn Pro Lys Leu Cys Leu Ile Lys Asp Ala Ser Glu Gln Ser Ser 
    610                 615                 620


Ser Ala Lys Ala Thr Pro Gly Lys Gly Ser Gln Ala Asn Ser Gly Ser 
625                 630                 635                 640


Ala Thr Lys Asn Thr Asn Val Lys Ser Leu Gln Glu Leu Cys Arg Met 
                645                 650                 655


Glu Ser Lys Thr Gly His Arg Asn Ser Glu His Gln Gln Gly His Leu 
            660                 665                 670


Arg Leu Val Val Pro Thr His Gly Asn Ser Ser Ala Ala Val Ser Thr 
        675                 680                 685


Pro Lys Asn Ser Gly Val Ala Glu Pro Val Tyr Lys Thr Ser Gln Lys 
    690                 695                 700


Lys Glu Asn Leu Ser Ala Arg Ser Val Thr Ser Ser Pro Val Glu Lys 
705                 710                 715                 720


Lys Asp Lys Glu Glu Thr Val Phe Gln Val Ser Tyr Pro Ser Ala Phe 
                725                 730                 735


Ser Lys Leu Val Ala Ser Arg Gln Val Ser Pro Leu Leu Ala Ser Gln 
            740                 745                 750


Ser Trp Ser Ser Arg Ser Met Ser Pro Asn Leu Leu Asn Arg Ala Ser 
        755                 760                 765


Pro Leu Ala Phe Asn Ile Ala Asn Ser Ser Ser Glu Ala Asp Cys Pro 
    770                 775                 780


Asp Pro Phe Ala Asn Gly Ala Asp Val Gln Val Ser Asn Ile Asp Tyr 
785                 790                 795                 800


Arg Leu Ser Arg Lys Glu Leu Gln Gln Leu Leu Gln Glu Ala Phe Ala 
                805                 810                 815


Arg His Gly Lys Val Lys Ser Val Glu Leu Ser Pro His Thr Asp Tyr 
            820                 825                 830


Gln Leu Lys Ala Val Val Gln Met Glu Asn Leu Gln Asp Ala Ile Gly 
        835                 840                 845


Ala Val Asn Ser Leu His Arg Tyr Lys Ile Gly Ser Lys Lys Ile Leu 
    850                 855                 860


Val Ser Leu Ala Thr Gly Ala Ala Ser Lys Ser Leu Ser Leu Leu Ser 
865                 870                 875                 880


Ala Glu Thr Met Ser Val Leu Gln Asp Ala Pro Ala Cys Cys Leu Pro 
                885                 890                 895


Leu Phe Lys Phe Thr Asp Ile Tyr Glu Lys Lys Phe Gly His Lys Leu 
            900                 905                 910


Asn Val Ser Asp Leu Tyr Lys Leu Thr Asp Thr Val Ala Ile Arg Glu 
        915                 920                 925


Gln Gly Asn Gly Arg Leu Val Cys Leu Leu Pro Ser Ser Gln Ala Arg 
    930                 935                 940


Gln Ser Pro Leu Gly Ser Ser Gln Ser His Asp Gly Ser Ser Thr Asn 
945                 950                 955                 960


Cys Ser Pro Ile Ile Phe Glu Glu Leu Glu Tyr His Glu Pro Val Cys 
                965                 970                 975


Arg Gln His Cys Ser Asn Lys Asp Phe Ser Glu His Glu Phe Asp Pro 
            980                 985                 990


Asp Ser Tyr Lys Ile Pro Phe Val Ile Leu Ser Leu Lys Thr Phe Ala 
        995                 1000                1005


Pro Gln Val His Ser Leu Leu Gln Thr His Glu Gly Thr Val Pro Leu 
    1010                1015                1020


Leu Ser Phe Pro Asp Cys Tyr Ile Ala Glu Phe Gly Asp Leu Glu Val 
1025                1030                1035                1040


Val Gln Glu Asn Gln Gly Gly Val Pro Leu Glu His Phe Ile Thr Cys 
                1045                1050                1055


Val Pro Gly Val Asn Ile Ala Thr Ala Gln Asn Gly Ile Lys Val Val 
            1060                1065                1070


Lys Trp Ile His Asn Lys Pro Pro Pro Pro Asn Thr Asp Pro Trp Leu 
        1075                1080                1085


Leu Arg Ser Lys Ser Pro Val Gly Asn Pro Gln Leu Ile Gln Phe Ser 
    1090                1095                1100


Arg Glu Val Ile Asp Leu Leu Lys Ser Gln Pro Ser Cys Val Ile Pro 
1105                1110                1115                1120


Ile Ser His Phe Ile Pro Ser Tyr His His His Phe Ala Lys Gln Cys 
                1125                1130                1135


Arg Val Ser Asp Tyr Gly Tyr Ser Lys Leu Ile Glu Leu Leu Glu Ala 
            1140                1145                1150


Val Pro His Val Leu Gln Ile Leu Gly Met Gly Ser Lys Arg Leu Leu 
        1155                1160                1165


Thr Leu Thr His Arg Ala Gln Val Lys Arg Phe Thr Gln Asp Leu Leu 
    1170                1175                1180


Lys Leu Leu Lys Ser Gln Ala Ser Lys Gln Val Ile Val Arg Glu Phe 
1185                1190                1195                1200


Ser Gln Ala Tyr His Trp Cys Phe Ser Lys Asp Trp Asp Val Thr Glu 
                1205                1210                1215


Tyr Gly Val Cys Glu Leu Ile Asp Ile Val Ser Glu Ile Pro Asp Thr 
            1220                1225                1230


Thr Ile Cys Leu Ser Gln Gln Asp Asn Glu Met Val Ile Cys Ile Pro 
        1235                1240                1245


Lys Arg Glu Arg Thr Gln Asp Glu Ile Glu Arg Thr Lys Gln Phe Ser 
    1250                1255                1260


Lys Asp Val Val Asp Leu Leu Arg His Gln Pro His Phe Arg Met Pro 
1265                1270                1275                1280


Phe Asn Lys Phe Ile Pro Ser Tyr His His His Phe Gly Arg Gln Cys 
                1285                1290                1295


Lys Leu Ala Tyr Tyr Gly Phe Thr Lys Leu Leu Glu Leu Phe Glu Ala 
            1300                1305                1310


Ile Pro Asp Thr Leu Gln Val Leu Glu Cys Gly Glu Glu Lys Ile Leu 
        1315                1320                1325


Thr Leu Thr Glu Val Glu Arg Phe Lys Ala Leu Ala Ala Gln Phe Val 
    1330                1335                1340


Lys Leu Leu Arg Ser Gln Lys Asp Asn Cys Leu Met Met Thr Asp Leu 
1345                1350                1355                1360


Leu Thr Glu Tyr Ala Lys Thr Phe Gly Tyr Thr Phe Arg Leu Gln Asp 
                1365                1370                1375


Tyr Asp Val Ser Ser Ile Ser Ala Leu Thr Gln Lys Leu Cys His Val 
            1380                1385                1390


Val Lys Val Ala Asp Ile Glu Ser Gly Arg Gln Ile Gln Leu Ile Asn 
        1395                1400                1405


Arg Lys Ser Leu Arg Ser Leu Thr Ala Gln Leu Leu Val Leu Leu Met 
    1410                1415                1420


Ser Trp Glu Gly Thr Thr His Leu Ser Val Glu Glu Leu Lys Arg His 
1425                1430                1435                1440


Tyr Glu Ser Thr His Asn Thr Pro Leu Asn Pro Cys Glu Tyr Gly Phe 
                1445                1450                1455


Met Thr Leu Thr Glu Leu Leu Lys Ser Leu Pro Tyr Leu Val Glu Val 
            1460                1465                1470


Phe Thr Asn Asp Lys Met Glu Glu Cys Val Lys Leu Thr Ser Leu Tyr 
        1475                1480                1485


Leu Phe Ala Lys Asn Val Arg Ser Leu Leu His Thr Tyr His Tyr Gln 
    1490                1495                1500


Gln Ile Phe Leu His Glu Phe Ser Met Ala Tyr Thr Lys Tyr Val Gly 
1505                1510                1515                1520


Glu Thr Leu Gln Pro Lys Thr Tyr Gly His Ser Ser Val Glu Glu Leu 
                1525                1530                1535


Leu Gly Ala Ile Pro Gln Val Val Trp Ile Lys Gly His Gly His Lys 
            1540                1545                1550


Arg Ile Val Val Leu Lys Asn Asp Met Lys Ser Arg Leu Ser Ser Leu 
        1555                1560                1565


Ser Leu Ser Pro Ala Asn His Glu Asn Gln Pro Ser Glu Gly Glu Arg 
    1570                1575                1580


Ile Leu Glu Val Pro Glu Ser His Thr Ala Ser Glu Leu Lys Leu Gly 
1585                1590                1595                1600


Ala Asp Gly Ser Gly Pro Ser His Thr Glu Gln Glu Leu Leu Arg Leu 
                1605                1610                1615


Thr Asp Asp Ser Pro Val Asp Leu Leu Cys Ala Pro Val Pro Ser Cys 
            1620                1625                1630


Leu Pro Ser Pro Gln Leu Arg Pro Asp Pro Val Ile Leu Gln Ser Ala 
        1635                1640                1645


Asp Leu Ile Gln Phe Glu Glu Arg Pro Gln Glu Pro Ser Glu Ile Met 
    1650                1655                1660


Ile Leu Asn Gln Glu Glu Lys Met Glu Ile Pro Ile Pro Gly Lys Ser 
1665                1670                1675                1680


Lys Thr Leu Thr Ser Asp Ser Ser Ser Ser Cys Ile Ser Ala Ala Val 
                1685                1690                1695


Pro Val Pro Pro Cys Pro Ser Ser Glu Thr Ser Glu Ser Leu Leu Ser 
            1700                1705                1710


Lys Asp Pro Val Glu Ser Pro Ala Lys Lys Gln Pro Lys Asn Arg Val 
        1715                1720                1725


Lys Leu Ala Ala Asn Phe Ser Leu Ala Pro Ile Thr Lys Leu 
    1730                1735                1740


<210>  1083
<211>  1997
<212>  DNA
<213>  Homo sapiens

<400>  1083
agccgcctct gccgccgccg ccgcgttggc ctcgccgccc ctgctcggac accatgccac     60

aaggagagtg atctcttccc ctgttttcac aatggaggac tccggaaaga ctttcagctc    120

cgaggaggaa gaagctaact attggaaaga tctggcgatg acctacaaac agagggcaga    180

aaatacgcaa gaggaactcc gagaattcca ggagggaagc cgagaatatg aagctgaatt    240

ggagacgcag ctgcaacaaa ttgaaaccag gaacagagac ctcctgtccg aaaataaccg    300

ccttcgcatg gagctggaaa ccatcaagga gaagtttgaa gtgcagcact ctgaaggcta    360

ccggcagatc tcagccttgg aggatgacct cgcgcagacc aaagccatta aagaccaatt    420

gcagaaatac atcagagagc tggagcaagc aaatgacgac ctggaaagag ccaagcgcgc    480

cacgatcatg tctctcgaag actttgagca gcgcttgaat caggccatcg aaagaaatgc    540

cttcctggaa agtgaacttg atgaaaaaga gaatctcctg gaatctgttc agagactgaa    600

ggatgaagcc agagatttgc ggcaggaact ggccgtgcag cagaagcagg agaaacccag    660

gacccccatg cccagctcag tggaagctga gaggacagac acagctgtgc aggccacggg    720

ctccgtgccg tccacgccca ttgctcaccg aggacccagc tcaagtttaa acacacctgg    780

gagcttcaga cgtggcctgg acgactccac cggggggacc cccctcacac ctgcggcccg    840

gatatcagcc ctcaacattg tgggagacct actgcggaaa gtcggggcac tggagtccaa    900

actcgcttcc tgccggaacc tcgtgtacga tcagtcccca aaccgaacag gtggcccagc    960

ctctgggcgg agcagcaaga acagagatgg cggggagaga cggccaagca gcaccagcgt   1020

gcctttgggt gataaggggt tggacacgag ttgccgctgg ttgtccaaat caacaaccag   1080

gtcgtccagc tcctgctgaa gcctgttctt ggtcttttcc agtttatcat acgcggccgc   1140

cttctcctcg tactgctggg tgaggttctc gatctccttc tggaacctct tcttcccctc   1200

ttccagagct tccacggtgc tggcaaagtc ctgcagcttc ttcttcgagt cggagagcta   1260

caaggacagc gtccagggta gggtgagagg gggaccatga atggcccctg tccctggccc   1320

cacagactct gagaagcgaa gaccatgtct cctcgttgga gaaacccaat agcaggggaa   1380

gctggggggt caagcaccat cgcaccaaca ctccaccgcg atctgcctgc gggggatctc   1440

agcgcagaga agttgagagg acccatgaag gaagcaagga cacggggcag gcacctggat   1500

gttgagagtg gagatgtggc gctccaggtt ctgcttggcc tccatctcct cgtccagctg   1560

gtcttgcagg ctgttccgct cctcctccag ctggcgcagc ttcgtagaca cgttgagctt   1620

ctgccgggtt tcttcttgaa gcagctcctg caaaagggat gcaaagaggt cccagggacc   1680

tgccccgagg aaggccaccc cccaggtccc ctggatgatg tggcaggaca ctcacctggg   1740

tgtcctggag ctgggaactg agggacgcca cgtccttggc cagcttaatg gccttcccct   1800

cggcctcgtt aagcatccct gtgacgctct caacttcatt ctaagggtgc caagagactg   1860

gttagtcaaa gcctctagaa ggggatcctc gttgaaagga gcccttttta ctcaaaacac   1920

atgggctagt acttgaggtg ttcactgatt gagaaaatac ccgtgaggta tgggactctg   1980

aaaaaaaaaa aaaaaaa                                                  1997


<210>  1084
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  1084

Met Glu Asp Ser Gly Lys Thr Phe Ser Ser Glu Glu Glu Glu Ala Asn 
1               5                   10                  15


Tyr Trp Lys Asp Leu Ala Met Thr Tyr Lys Gln Arg Ala Glu Asn Thr 
            20                  25                  30


Gln Glu Glu Leu Arg Glu Phe Gln Glu Gly Ser Arg Glu Tyr Glu Ala 
        35                  40                  45


Glu Leu Glu Thr Gln Leu Gln Gln Ile Glu Thr Arg Asn Arg Asp Leu 
    50                  55                  60


Leu Ser Glu Asn Asn Arg Leu Arg Met Glu Leu Glu Thr Ile Lys Glu 
65                  70                  75                  80


Lys Phe Glu Val Gln His Ser Glu Gly Tyr Arg Gln Ile Ser Ala Leu 
                85                  90                  95


Glu Asp Asp Leu Ala Gln Thr Lys Ala Ile Lys Asp Gln Leu Gln Lys 
            100                 105                 110


Tyr Ile Arg Glu Leu Glu Gln Ala Asn Asp Asp Leu Glu Arg Ala Lys 
        115                 120                 125


Arg Ala Thr Ile Met Ser Leu Glu Asp Phe Glu Gln Arg Leu Asn Gln 
    130                 135                 140


Ala Ile Glu Arg Asn Ala Phe Leu Glu Ser Glu Leu Asp Glu Lys Glu 
145                 150                 155                 160


Asn Leu Leu Glu Ser Val Gln Arg Leu Lys Asp Glu Ala Arg Asp Leu 
                165                 170                 175


Arg Gln Glu Leu Ala Val Gln Gln Lys Gln Glu Lys Pro Arg Thr Pro 
            180                 185                 190


Met Pro Ser Ser Val Glu Ala Glu Arg Thr Asp Thr Ala Val Gln Ala 
        195                 200                 205


Thr Gly Ser Val Pro Ser Thr Pro Ile Ala His Arg Gly Pro Ser Ser 
    210                 215                 220


Ser Leu Asn Thr Pro Gly Ser Phe Arg Arg Gly Leu Asp Asp Ser Thr 
225                 230                 235                 240


Gly Gly Thr Pro Leu Thr Pro Ala Ala Arg Ile Ser Ala Leu Asn Ile 
                245                 250                 255


Val Gly Asp Leu Leu Arg Lys Val Gly Ala Leu Glu Ser Lys Leu Ala 
            260                 265                 270


Ser Cys Arg Asn Leu Val Tyr Asp Gln Ser Pro Asn Arg Thr Gly Gly 
        275                 280                 285


Pro Ala Ser Gly Arg Ser Ser Lys Asn Arg Asp Gly Gly Glu Arg Arg 
    290                 295                 300


Pro Ser Ser Thr Ser Val Pro Leu Gly Asp Lys Gly Leu Asp Thr Ser 
305                 310                 315                 320


Cys Arg Trp Leu Ser Lys Ser Thr Thr Arg Ser Ser Ser Ser Cys 
                325                 330                 335


<210>  1085
<211>  6942
<212>  DNA
<213>  Homo sapiens

<400>  1085
gggagatttg gacgctccgg cctgggaggt gcgtcagatc cgagctcgcc atccagtttc     60

ctctccacta gtccccccag ttggagatct gggaccaaca aggcaccatg gcgcagaagg    120

gccaactcag tgacgatgag aagttcctct ttgtggacaa aaacttcatc aacagcccag    180

tggcccaggc tgactgggcc gccaagagac tcgtctgggt cccctcggag aagcagggct    240

tcgaggcagc cagcattaag gaggagaagg gggatgaggt ggttgtggag ctggtggaga    300

atggcaagaa ggtcacggtt gggaaagatg acatccagaa gatgaaccca cccaagttct    360

ccaaggtgga ggacatggcg gagctgacgt gcctcaacga agcctccgtg ctacacaacc    420

tgagggagcg gtacttctca gggctaatat atacgtactc tggcctcttc tgcgtggtgg    480

tcaaccccta taaacacctg cccatctact cggagaagat cgtcgacatg tacaagggca    540

agaagaggca cgagatgccg cctcacatct acgccatcgc agacacggcc taccggagca    600

tgcttcaaga tcgggaggac cagtccattc tatgcacagg cgagtctgga gccgggaaaa    660

ccgaaaacac caagaaggtc attcagtacc tggccgtggt ggcctcctcc cacaagggca    720

agaaagacac aagtatcacg caaggcccat cttttgccta cggagagctg gaaaagcagc    780

ttctacaagc aaacccgatt ctggaggctt tcggcaacgc caaaacagtg aagaacgaca    840

actcctcacg attcggcaaa ttcatccgca tcaacttcga cgtcacgggt tacatcgtgg    900

gagccaacat tgagacctat ctgctagaaa aatcacgggc aattcgccaa gccagagacg    960

agaggacatt ccacatcttt tactacatga ttgctggagc caaggagaag atgagaagtg   1020

acttgctttt ggagggcttc aacaactaca ccttcctctc caatggcttt gtgcccatcc   1080

cagcagccca ggatgatgag atgttccagg aaaccgtgga ggccatggca atcatgggtt   1140

tcagcgagga ggagcagcta tccatattga aggtggtatc atcggtcctg cagcttggaa   1200

atatcgtctt caagaaggaa agaaacacag accaggcgtc catgccagat aacacagctg   1260

ctcagaaagt ttgccacctc atgggaatta atgtgacaga tttcaccaga tccatcctca   1320

ctcctcgtat caaggttggg cgagatgtgg tacagaaagc tcagacaaaa gaacaggctg   1380

actttgctgt agaggctttg gccaaggcaa catatgagcg ccttttccgc tggatactca   1440

cccgcgtgaa caaagccctg gacaagaccc atcggcaagg ggcttccttc ctggggatcc   1500

tggatatagc tggatttgag atctttgagg tgaactcctt cgagcagctg tgcatcaact   1560

acaccaacga gaagctgcag cagctcttca accacaccat gttcatcctg gagcaggagg   1620

agtaccagcg cgagggcatc gagtggaact tcatcgactt tgggctggac ctacagccct   1680

gcatcgagct catcgagcga ccgaacaacc ctccaggtgt gctggccctg ctggacgagg   1740

aatgctggtt ccccaaagcc acggacaagt ctttcgtgga gaagctgtgc acggagcagg   1800

gcagccaccc caagttccag aagcccaagc agctcaagga caagactgag ttctccatca   1860

tccattatgc tgggaaggtg gactataatg cgagtgcctg gctgaccaag aatatggacc   1920

cgctgaatga caacgtgact tccctgctca atgcctcctc cgacaagttt gtggccgacc   1980

tgtggaagga cgtggaccgc atcgtgggcc tggaccagat ggccaagatg acggagagct   2040

cgctgcccag cgcctccaag accaagaagg gcatgttccg cacagtgggg cagctgtaca   2100

aggagcagct gggcaagctg atgaccacgc tacgcaacac cacgcccaac ttcgtgcgct   2160

gcatcatccc caaccacgag aagaggtccg gcaagctgga tgcgttcctg gtgctggagc   2220

agctgcggtg caatggggtg ctggaaggca ttcgcatctg ccggcagggc ttccccaacc   2280

ggatcgtctt ccaggagttc cgccaacgct acgagatcct ggcggcgaat gccatcccca   2340

aaggcttcat ggacgggaag caggcctgca ttctcatgat caaagccctg gaacttgacc   2400

ccaacttata caggataggg cagagcaaaa tcttcttccg aactggcgtc ctggcccacc   2460

tagaggagga gcgagatttg aagatcaccg atgtcatcat ggccttccag gcgatgtgtc   2520

gtggctactt ggccagaaag gcttttgcca agaggcagca gcagctgacc gccatgaagg   2580

tgattcagag gaactgcgcc gcctacctca agctgcggaa ctggcagtgg tggaggcttt   2640

tcaccaaagt gaagccactg ctgcaggtga cacggcagga ggaggagatg caggccaagg   2700

aggatgaact gcagaagacc aaggagcggc agcagaaggc agagaatgag cttaaggagc   2760

tggaacagaa gcactcgcag ctgaccgagg agaagaacct gctacaggaa cagctgcagg   2820

cagagacaga gctgtatgca gaggctgagg agatgcgggt gcggctggcg gccaagaagc   2880

aggagctgga ggagatactg catgagatgg aggcccgcct ggaggaggag gaagacaggg   2940

gccagcagct acaggctgaa aggaagaaga tggcccagca gatgctggac cttgaagaac   3000

agctggagga ggaggaagct gccaggcaga agctgcaact tgagaaggtc acggctgagg   3060

ccaagatcaa gaaactggag gatgagatcc tggtcatgga tgatcagaac aataaactat   3120

caaaagaacg aaaactcctt gaggagagga ttagtgactt aacgacaaat cttgcagaag   3180

aggaagaaaa ggccaagaat cttaccaagc tgaaaaacaa gcatgaatct atgatttcag   3240

aactggaagt gcggctaaag aaggaagaga agagccgaca ggagctggag aagctgaaac   3300

ggaagctgga gggtgatgcc agcgacttcc acgagcagat cgctgacctc caggcgcaga   3360

tcgcagagct caagatgcag ctggccaaga aggaggagga gctgcaggcg gccctggcca   3420

ggcttgacga tgaaatcgct cagaagaaca atgccctgaa gaagatccgg gagctggagg   3480

gccacatctc agacctccag gaggacctgg actcagagcg ggccgccagg aacaaggctg   3540

aaaagcagaa gcgagacctc ggcgaggagc tggaggccct aaagacagag ctggaagaca   3600

cactggacag cacagccact cagcaggagc tcagggccaa gagggagcag gaggtgacgg   3660

tgctgaagaa ggccctggat gaagagacgc ggtcccatga ggctcaggtc caggagatga   3720

ggcagaaaca cgcacaggcg gtggaggagc tcacagagca gcttgagcag ttcaagaggg   3780

ccaaggcgaa cctagacaag aataagcaga cgctggagaa agagaacgca gacctggccg   3840

gggagctgcg ggtcctgggc caggccaagc aggaggtgga acataagaag aagaagctgg   3900

aggcgcaggt gcaggagctg cagtccaagt gcagcgatgg ggagcgggcc cgggcggagc   3960

tcaatgacaa agtccacaag ctgcagaatg aagttgagag cgtcacaggg atgcttaacg   4020

aggccgaggg gaaggccatt aagctggcca aggacgtggc gtccctcagt tcccagctcc   4080

aggacaccca ggagctgctt caagaagaaa cccggcagaa gctcaacgtg tctacgaagc   4140

tgcgccagct ggaggaggag cggaacagcc tgcaagacca gctggacgag gagatggagg   4200

ccaagcagaa cctggagcgc cacatctcca ctctcaacat ccagctctcc gactcgaaga   4260

agaagctgca ggactttgcc agcaccgtgg aagctctgga agaggggaag aagaggttcc   4320

agaaggagat cgagaacctc acccagcagt acgaggagaa ggcggccgct tatgataaac   4380

tggaaaagac caagaacagg cttcagcagg agctggacga cctggttgtt gatttggaca   4440

accagcggca actcgtgtcc aacctggaaa agaagcagag gaaatttgat cagttgttag   4500

ccgaggagaa aaacatctct tccaaatacg cggatgagag ggacagagct gaggcagaag   4560

ccagggagaa ggaaaccaag gccctgtccc tggctcgggc ccttgaagag gccttggaag   4620

ccaaagagga actcgagcgg accaacaaaa tgctcaaagc cgaaatggaa gacctggtca   4680

gctccaagga tgacgtgggc aagaacgtcc atgagctgga gaagtccaag cgggccctgg   4740

agacccagat ggaggagatg aagacgcagc tggaagagct ggaggacgag ctgcaagcca   4800

cggaggacgc caaactgcgg ctggaagtca acatgcaggc gctcaagggc cagttcgaaa   4860

gggatctcca agcccgggac gagcagaatg aggagaagag gaggcaactg cagagacagc   4920

ttcacgagta tgagacggaa ctggaagacg agcgaaagca acgtgccctg gcagctgcag   4980

caaagaagaa gctggaaggg gacctgaaag acctggagct tcaggccgac tctgccatca   5040

aggggaggga ggaagccatc aagcagctac gcaaactgca ggctcagatg aaggactttc   5100

aaagagagct ggaagatgcc cgtgcctcca gagatgagat ctttgccaca gccaaagaga   5160

atgagaagaa agccaagagc ttggaagcag acctcatgca gctacaagag gacctcgccg   5220

ccgctgagag ggctcgcaaa caagcggacc tcgagaagga ggaactggca gaggagctgg   5280

ccagtagcct gtcgggaagg aacgcactcc aggacgagaa gcgccgcctg gaggcccgga   5340

tcgcccagct ggaggaggag ctggaggagg agcagggcaa catggaggcc atgagcgacc   5400

gggtccgcaa agccacacag caggccgagc agctcagcaa cgagctggcc acagagcgca   5460

gcacggccca gaagaatgag agtgcccggc agcagctcga gcggcagaac aaggagctcc   5520

ggagcaagct ccacgagatg gagggggccg tcaagtccaa gttcaagtcc accatcgcgg   5580

cgctggaggc caagattgca cagctggagg agcaggtcga gcaggaggcc agagagaaac   5640

aggcggccac caagtcgctg aagcagaaag acaagaagct gaaggaaatc ttgctgcagg   5700

tggaggacga gcgcaagatg gccgagcagt acaaggagca ggcagagaaa ggcaatgcca   5760

gggtcaagca gctcaagagg cagctggagg aggcagagga ggagtcccag cgcatcaacg   5820

ccaaccgcag gaagctgcag cgggagctgg atgaggccac ggagagcaac gaggccatgg   5880

gccgcgaggt gaacgcactc aagagcaagc tcagagggcc ccccccacag gaaacttcgc   5940

agtgatgcac caggcgagga aacgagacct ctttcgttcc ttctagaagg tctggaggac   6000

gtagagttat tgaaaatgca gatggttctg aggaggaaac ggacactcga gacgcagact   6060

tcaatggaac caaggccagt gaataagcaa ctttctacag ttttgcacca cggcaagaaa   6120

accaaaaacc aaaacaaaca aacaaaaaaa acccaacaac aacccagaac aaagcaaaac   6180

ccagcagact gtacttagca ttgtctaaat ccattctcaa attccaaata tcacagacac   6240

ccctcacaca aggaatataa aaaccaccac cctccagcct gggcaacgta gtaaaacctc   6300

atctatacaa gaatttaaaa ataagctggg cgtggtggta cacacctgtg gtcccagcta   6360

ctagggaggc tgagccagga agaacgctcc agcccaggac ttcgaggctg caatgagcta   6420

taattgcatc attgcactcc agcctgggca acagagaccc tgtctcaacc accaccacca   6480

ccaccacccc tactacccct gtattcaagg taaaaattga agtttgtatg atgtaagaga   6540

tgagaaaaac ccaacaggaa acacagacac atcctccagt tctatcaatg gattgtgcag   6600

acactgagtt tttagaaaaa catatccacg gtaaccggtc cctggcaatt ctgtttacat   6660

gaaatgggga gaaagtcacc gaaatgggtg ccgccggccc ccactcccaa ttcattccct   6720

aacctgcaaa cctttccaac ttctcacgtc aggcctttga gaattctttc cccctctcct   6780

ggtttccaca cctcagacac gcacagttca ccaagtgcct tctgtagtca catgaattga   6840

aaaggagacg ctgctcccac ggaggggagc aggaatgctg cactgtttac accctgactg   6900

tgcttaaaaa cactttcact aataaatggt tataaatcac aa                      6942


<210>  1086
<211>  1945
<212>  PRT
<213>  Homo sapiens

<400>  1086

Met Ala Gln Lys Gly Gln Leu Ser Asp Asp Glu Lys Phe Leu Phe Val 
1               5                   10                  15


Asp Lys Asn Phe Ile Asn Ser Pro Val Ala Gln Ala Asp Trp Ala Ala 
            20                  25                  30


Lys Arg Leu Val Trp Val Pro Ser Glu Lys Gln Gly Phe Glu Ala Ala 
        35                  40                  45


Ser Ile Lys Glu Glu Lys Gly Asp Glu Val Val Val Glu Leu Val Glu 
    50                  55                  60


Asn Gly Lys Lys Val Thr Val Gly Lys Asp Asp Ile Gln Lys Met Asn 
65                  70                  75                  80


Pro Pro Lys Phe Ser Lys Val Glu Asp Met Ala Glu Leu Thr Cys Leu 
                85                  90                  95


Asn Glu Ala Ser Val Leu His Asn Leu Arg Glu Arg Tyr Phe Ser Gly 
            100                 105                 110


Leu Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Val Val Asn Pro Tyr 
        115                 120                 125


Lys His Leu Pro Ile Tyr Ser Glu Lys Ile Val Asp Met Tyr Lys Gly 
    130                 135                 140


Lys Lys Arg His Glu Met Pro Pro His Ile Tyr Ala Ile Ala Asp Thr 
145                 150                 155                 160


Ala Tyr Arg Ser Met Leu Gln Asp Arg Glu Asp Gln Ser Ile Leu Cys 
                165                 170                 175


Thr Gly Glu Ser Gly Ala Gly Lys Thr Glu Asn Thr Lys Lys Val Ile 
            180                 185                 190


Gln Tyr Leu Ala Val Val Ala Ser Ser His Lys Gly Lys Lys Asp Thr 
        195                 200                 205


Ser Ile Thr Gln Gly Pro Ser Phe Ala Tyr Gly Glu Leu Glu Lys Gln 
    210                 215                 220


Leu Leu Gln Ala Asn Pro Ile Leu Glu Ala Phe Gly Asn Ala Lys Thr 
225                 230                 235                 240


Val Lys Asn Asp Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile Asn 
                245                 250                 255


Phe Asp Val Thr Gly Tyr Ile Val Gly Ala Asn Ile Glu Thr Tyr Leu 
            260                 265                 270


Leu Glu Lys Ser Arg Ala Ile Arg Gln Ala Arg Asp Glu Arg Thr Phe 
        275                 280                 285


His Ile Phe Tyr Tyr Met Ile Ala Gly Ala Lys Glu Lys Met Arg Ser 
    290                 295                 300


Asp Leu Leu Leu Glu Gly Phe Asn Asn Tyr Thr Phe Leu Ser Asn Gly 
305                 310                 315                 320


Phe Val Pro Ile Pro Ala Ala Gln Asp Asp Glu Met Phe Gln Glu Thr 
                325                 330                 335


Val Glu Ala Met Ala Ile Met Gly Phe Ser Glu Glu Glu Gln Leu Ser 
            340                 345                 350


Ile Leu Lys Val Val Ser Ser Val Leu Gln Leu Gly Asn Ile Val Phe 
        355                 360                 365


Lys Lys Glu Arg Asn Thr Asp Gln Ala Ser Met Pro Asp Asn Thr Ala 
    370                 375                 380


Ala Gln Lys Val Cys His Leu Met Gly Ile Asn Val Thr Asp Phe Thr 
385                 390                 395                 400


Arg Ser Ile Leu Thr Pro Arg Ile Lys Val Gly Arg Asp Val Val Gln 
                405                 410                 415


Lys Ala Gln Thr Lys Glu Gln Ala Asp Phe Ala Val Glu Ala Leu Ala 
            420                 425                 430


Lys Ala Thr Tyr Glu Arg Leu Phe Arg Trp Ile Leu Thr Arg Val Asn 
        435                 440                 445


Lys Ala Leu Asp Lys Thr His Arg Gln Gly Ala Ser Phe Leu Gly Ile 
    450                 455                 460


Leu Asp Ile Ala Gly Phe Glu Ile Phe Glu Val Asn Ser Phe Glu Gln 
465                 470                 475                 480


Leu Cys Ile Asn Tyr Thr Asn Glu Lys Leu Gln Gln Leu Phe Asn His 
                485                 490                 495


Thr Met Phe Ile Leu Glu Gln Glu Glu Tyr Gln Arg Glu Gly Ile Glu 
            500                 505                 510


Trp Asn Phe Ile Asp Phe Gly Leu Asp Leu Gln Pro Cys Ile Glu Leu 
        515                 520                 525


Ile Glu Arg Pro Asn Asn Pro Pro Gly Val Leu Ala Leu Leu Asp Glu 
    530                 535                 540


Glu Cys Trp Phe Pro Lys Ala Thr Asp Lys Ser Phe Val Glu Lys Leu 
545                 550                 555                 560


Cys Thr Glu Gln Gly Ser His Pro Lys Phe Gln Lys Pro Lys Gln Leu 
                565                 570                 575


Lys Asp Lys Thr Glu Phe Ser Ile Ile His Tyr Ala Gly Lys Val Asp 
            580                 585                 590


Tyr Asn Ala Ser Ala Trp Leu Thr Lys Asn Met Asp Pro Leu Asn Asp 
        595                 600                 605


Asn Val Thr Ser Leu Leu Asn Ala Ser Ser Asp Lys Phe Val Ala Asp 
    610                 615                 620


Leu Trp Lys Asp Val Asp Arg Ile Val Gly Leu Asp Gln Met Ala Lys 
625                 630                 635                 640


Met Thr Glu Ser Ser Leu Pro Ser Ala Ser Lys Thr Lys Lys Gly Met 
                645                 650                 655


Phe Arg Thr Val Gly Gln Leu Tyr Lys Glu Gln Leu Gly Lys Leu Met 
            660                 665                 670


Thr Thr Leu Arg Asn Thr Thr Pro Asn Phe Val Arg Cys Ile Ile Pro 
        675                 680                 685


Asn His Glu Lys Arg Ser Gly Lys Leu Asp Ala Phe Leu Val Leu Glu 
    690                 695                 700


Gln Leu Arg Cys Asn Gly Val Leu Glu Gly Ile Arg Ile Cys Arg Gln 
705                 710                 715                 720


Gly Phe Pro Asn Arg Ile Val Phe Gln Glu Phe Arg Gln Arg Tyr Glu 
                725                 730                 735


Ile Leu Ala Ala Asn Ala Ile Pro Lys Gly Phe Met Asp Gly Lys Gln 
            740                 745                 750


Ala Cys Ile Leu Met Ile Lys Ala Leu Glu Leu Asp Pro Asn Leu Tyr 
        755                 760                 765


Arg Ile Gly Gln Ser Lys Ile Phe Phe Arg Thr Gly Val Leu Ala His 
    770                 775                 780


Leu Glu Glu Glu Arg Asp Leu Lys Ile Thr Asp Val Ile Met Ala Phe 
785                 790                 795                 800


Gln Ala Met Cys Arg Gly Tyr Leu Ala Arg Lys Ala Phe Ala Lys Arg 
                805                 810                 815


Gln Gln Gln Leu Thr Ala Met Lys Val Ile Gln Arg Asn Cys Ala Ala 
            820                 825                 830


Tyr Leu Lys Leu Arg Asn Trp Gln Trp Trp Arg Leu Phe Thr Lys Val 
        835                 840                 845


Lys Pro Leu Leu Gln Val Thr Arg Gln Glu Glu Glu Met Gln Ala Lys 
    850                 855                 860


Glu Asp Glu Leu Gln Lys Thr Lys Glu Arg Gln Gln Lys Ala Glu Asn 
865                 870                 875                 880


Glu Leu Lys Glu Leu Glu Gln Lys His Ser Gln Leu Thr Glu Glu Lys 
                885                 890                 895


Asn Leu Leu Gln Glu Gln Leu Gln Ala Glu Thr Glu Leu Tyr Ala Glu 
            900                 905                 910


Ala Glu Glu Met Arg Val Arg Leu Ala Ala Lys Lys Gln Glu Leu Glu 
        915                 920                 925


Glu Ile Leu His Glu Met Glu Ala Arg Leu Glu Glu Glu Glu Asp Arg 
    930                 935                 940


Gly Gln Gln Leu Gln Ala Glu Arg Lys Lys Met Ala Gln Gln Met Leu 
945                 950                 955                 960


Asp Leu Glu Glu Gln Leu Glu Glu Glu Glu Ala Ala Arg Gln Lys Leu 
                965                 970                 975


Gln Leu Glu Lys Val Thr Ala Glu Ala Lys Ile Lys Lys Leu Glu Asp 
            980                 985                 990


Glu Ile Leu Val Met Asp Asp Gln Asn Asn Lys Leu Ser Lys Glu Arg 
        995                 1000                1005


Lys Leu Leu Glu Glu Arg Ile Ser Asp Leu Thr Thr Asn Leu Ala Glu 
    1010                1015                1020


Glu Glu Glu Lys Ala Lys Asn Leu Thr Lys Leu Lys Asn Lys His Glu 
1025                1030                1035                1040


Ser Met Ile Ser Glu Leu Glu Val Arg Leu Lys Lys Glu Glu Lys Ser 
                1045                1050                1055


Arg Gln Glu Leu Glu Lys Leu Lys Arg Lys Leu Glu Gly Asp Ala Ser 
            1060                1065                1070


Asp Phe His Glu Gln Ile Ala Asp Leu Gln Ala Gln Ile Ala Glu Leu 
        1075                1080                1085


Lys Met Gln Leu Ala Lys Lys Glu Glu Glu Leu Gln Ala Ala Leu Ala 
    1090                1095                1100


Arg Leu Asp Asp Glu Ile Ala Gln Lys Asn Asn Ala Leu Lys Lys Ile 
1105                1110                1115                1120


Arg Glu Leu Glu Gly His Ile Ser Asp Leu Gln Glu Asp Leu Asp Ser 
                1125                1130                1135


Glu Arg Ala Ala Arg Asn Lys Ala Glu Lys Gln Lys Arg Asp Leu Gly 
            1140                1145                1150


Glu Glu Leu Glu Ala Leu Lys Thr Glu Leu Glu Asp Thr Leu Asp Ser 
        1155                1160                1165


Thr Ala Thr Gln Gln Glu Leu Arg Ala Lys Arg Glu Gln Glu Val Thr 
    1170                1175                1180


Val Leu Lys Lys Ala Leu Asp Glu Glu Thr Arg Ser His Glu Ala Gln 
1185                1190                1195                1200


Val Gln Glu Met Arg Gln Lys His Ala Gln Ala Val Glu Glu Leu Thr 
                1205                1210                1215


Glu Gln Leu Glu Gln Phe Lys Arg Ala Lys Ala Asn Leu Asp Lys Asn 
            1220                1225                1230


Lys Gln Thr Leu Glu Lys Glu Asn Ala Asp Leu Ala Gly Glu Leu Arg 
        1235                1240                1245


Val Leu Gly Gln Ala Lys Gln Glu Val Glu His Lys Lys Lys Lys Leu 
    1250                1255                1260


Glu Ala Gln Val Gln Glu Leu Gln Ser Lys Cys Ser Asp Gly Glu Arg 
1265                1270                1275                1280


Ala Arg Ala Glu Leu Asn Asp Lys Val His Lys Leu Gln Asn Glu Val 
                1285                1290                1295


Glu Ser Val Thr Gly Met Leu Asn Glu Ala Glu Gly Lys Ala Ile Lys 
            1300                1305                1310


Leu Ala Lys Asp Val Ala Ser Leu Ser Ser Gln Leu Gln Asp Thr Gln 
        1315                1320                1325


Glu Leu Leu Gln Glu Glu Thr Arg Gln Lys Leu Asn Val Ser Thr Lys 
    1330                1335                1340


Leu Arg Gln Leu Glu Glu Glu Arg Asn Ser Leu Gln Asp Gln Leu Asp 
1345                1350                1355                1360


Glu Glu Met Glu Ala Lys Gln Asn Leu Glu Arg His Ile Ser Thr Leu 
                1365                1370                1375


Asn Ile Gln Leu Ser Asp Ser Lys Lys Lys Leu Gln Asp Phe Ala Ser 
            1380                1385                1390


Thr Val Glu Ala Leu Glu Glu Gly Lys Lys Arg Phe Gln Lys Glu Ile 
        1395                1400                1405


Glu Asn Leu Thr Gln Gln Tyr Glu Glu Lys Ala Ala Ala Tyr Asp Lys 
    1410                1415                1420


Leu Glu Lys Thr Lys Asn Arg Leu Gln Gln Glu Leu Asp Asp Leu Val 
1425                1430                1435                1440


Val Asp Leu Asp Asn Gln Arg Gln Leu Val Ser Asn Leu Glu Lys Lys 
                1445                1450                1455


Gln Arg Lys Phe Asp Gln Leu Leu Ala Glu Glu Lys Asn Ile Ser Ser 
            1460                1465                1470


Lys Tyr Ala Asp Glu Arg Asp Arg Ala Glu Ala Glu Ala Arg Glu Lys 
        1475                1480                1485


Glu Thr Lys Ala Leu Ser Leu Ala Arg Ala Leu Glu Glu Ala Leu Glu 
    1490                1495                1500


Ala Lys Glu Glu Leu Glu Arg Thr Asn Lys Met Leu Lys Ala Glu Met 
1505                1510                1515                1520


Glu Asp Leu Val Ser Ser Lys Asp Asp Val Gly Lys Asn Val His Glu 
                1525                1530                1535


Leu Glu Lys Ser Lys Arg Ala Leu Glu Thr Gln Met Glu Glu Met Lys 
            1540                1545                1550


Thr Gln Leu Glu Glu Leu Glu Asp Glu Leu Gln Ala Thr Glu Asp Ala 
        1555                1560                1565


Lys Leu Arg Leu Glu Val Asn Met Gln Ala Leu Lys Gly Gln Phe Glu 
    1570                1575                1580


Arg Asp Leu Gln Ala Arg Asp Glu Gln Asn Glu Glu Lys Arg Arg Gln 
1585                1590                1595                1600


Leu Gln Arg Gln Leu His Glu Tyr Glu Thr Glu Leu Glu Asp Glu Arg 
                1605                1610                1615


Lys Gln Arg Ala Leu Ala Ala Ala Ala Lys Lys Lys Leu Glu Gly Asp 
            1620                1625                1630


Leu Lys Asp Leu Glu Leu Gln Ala Asp Ser Ala Ile Lys Gly Arg Glu 
        1635                1640                1645


Glu Ala Ile Lys Gln Leu Arg Lys Leu Gln Ala Gln Met Lys Asp Phe 
    1650                1655                1660


Gln Arg Glu Leu Glu Asp Ala Arg Ala Ser Arg Asp Glu Ile Phe Ala 
1665                1670                1675                1680


Thr Ala Lys Glu Asn Glu Lys Lys Ala Lys Ser Leu Glu Ala Asp Leu 
                1685                1690                1695


Met Gln Leu Gln Glu Asp Leu Ala Ala Ala Glu Arg Ala Arg Lys Gln 
            1700                1705                1710


Ala Asp Leu Glu Lys Glu Glu Leu Ala Glu Glu Leu Ala Ser Ser Leu 
        1715                1720                1725


Ser Gly Arg Asn Ala Leu Gln Asp Glu Lys Arg Arg Leu Glu Ala Arg 
    1730                1735                1740


Ile Ala Gln Leu Glu Glu Glu Leu Glu Glu Glu Gln Gly Asn Met Glu 
1745                1750                1755                1760


Ala Met Ser Asp Arg Val Arg Lys Ala Thr Gln Gln Ala Glu Gln Leu 
                1765                1770                1775


Ser Asn Glu Leu Ala Thr Glu Arg Ser Thr Ala Gln Lys Asn Glu Ser 
            1780                1785                1790


Ala Arg Gln Gln Leu Glu Arg Gln Asn Lys Glu Leu Arg Ser Lys Leu 
        1795                1800                1805


His Glu Met Glu Gly Ala Val Lys Ser Lys Phe Lys Ser Thr Ile Ala 
    1810                1815                1820


Ala Leu Glu Ala Lys Ile Ala Gln Leu Glu Glu Gln Val Glu Gln Glu 
1825                1830                1835                1840


Ala Arg Glu Lys Gln Ala Ala Thr Lys Ser Leu Lys Gln Lys Asp Lys 
                1845                1850                1855


Lys Leu Lys Glu Ile Leu Leu Gln Val Glu Asp Glu Arg Lys Met Ala 
            1860                1865                1870


Glu Gln Tyr Lys Glu Gln Ala Glu Lys Gly Asn Ala Arg Val Lys Gln 
        1875                1880                1885


Leu Lys Arg Gln Leu Glu Glu Ala Glu Glu Glu Ser Gln Arg Ile Asn 
    1890                1895                1900


Ala Asn Arg Arg Lys Leu Gln Arg Glu Leu Asp Glu Ala Thr Glu Ser 
1905                1910                1915                1920


Asn Glu Ala Met Gly Arg Glu Val Asn Ala Leu Lys Ser Lys Leu Arg 
                1925                1930                1935


Gly Pro Pro Pro Gln Glu Thr Ser Gln 
            1940                1945


<210>  1087
<211>  6903
<212>  DNA
<213>  Homo sapiens

<400>  1087
gggagatttg gacgctccgg cctgggaggt gcgtcagatc cgagctcgcc atccagtttc     60

ctctccacta gtccccccag ttggagatct gggaccaaca aggcaccatg gcgcagaagg    120

gccaactcag tgacgatgag aagttcctct ttgtggacaa aaacttcatc aacagcccag    180

tggcccaggc tgactgggcc gccaagagac tcgtctgggt cccctcggag aagcagggct    240

tcgaggcagc cagcattaag gaggagaagg gggatgaggt ggttgtggag ctggtggaga    300

atggcaagaa ggtcacggtt gggaaagatg acatccagaa gatgaaccca cccaagttct    360

ccaaggtgga ggacatggcg gagctgacgt gcctcaacga agcctccgtg ctacacaacc    420

tgagggagcg gtacttctca gggctaatat atacgtactc tggcctcttc tgcgtggtgg    480

tcaaccccta taaacacctg cccatctact cggagaagat cgtcgacatg tacaagggca    540

agaagaggca cgagatgccg cctcacatct acgccatcgc agacacggcc taccggagca    600

tgcttcaaga tcgggaggac cagtccattc tatgcacagg cgagtctgga gccgggaaaa    660

ccgaaaacac caagaaggtc attcagtacc tggccgtggt ggcctcctcc cacaagggca    720

agaaagacac aagtatcacg caaggcccat cttttgccta cggagagctg gaaaagcagc    780

ttctacaagc aaacccgatt ctggaggctt tcggcaacgc caaaacagtg aagaacgaca    840

actcctcacg attcggcaaa ttcatccgca tcaacttcga cgtcacgggt tacatcgtgg    900

gagccaacat tgagacctat ctgctagaaa aatcacgggc aattcgccaa gccagagacg    960

agaggacatt ccacatcttt tactacatga ttgctggagc caaggagaag atgagaagtg   1020

acttgctttt ggagggcttc aacaactaca ccttcctctc caatggcttt gtgcccatcc   1080

cagcagccca ggatgatgag atgttccagg aaaccgtgga ggccatggca atcatgggtt   1140

tcagcgagga ggagcagcta tccatattga aggtggtatc atcggtcctg cagcttggaa   1200

atatcgtctt caagaaggaa agaaacacag accaggcgtc catgccagat aacacagctg   1260

ctcagaaagt ttgccacctc atgggaatta atgtgacaga tttcaccaga tccatcctca   1320

ctcctcgtat caaggttggg cgagatgtgg tacagaaagc tcagacaaaa gaacaggctg   1380

actttgctgt agaggctttg gccaaggcaa catatgagcg ccttttccgc tggatactca   1440

cccgcgtgaa caaagccctg gacaagaccc atcggcaagg ggcttccttc ctggggatcc   1500

tggatatagc tggatttgag atctttgagg tgaactcctt cgagcagctg tgcatcaact   1560

acaccaacga gaagctgcag cagctcttca accacaccat gttcatcctg gagcaggagg   1620

agtaccagcg cgagggcatc gagtggaact tcatcgactt tgggctggac ctacagccct   1680

gcatcgagct catcgagcga ccgaacaacc ctccaggtgt gctggccctg ctggacgagg   1740

aatgctggtt ccccaaagcc acggacaagt ctttcgtgga gaagctgtgc acggagcagg   1800

gcagccaccc caagttccag aagcccaagc agctcaagga caagactgag ttctccatca   1860

tccattatgc tgggaaggtg gactataatg cgagtgcctg gctgaccaag aatatggacc   1920

cgctgaatga caacgtgact tccctgctca atgcctcctc cgacaagttt gtggccgacc   1980

tgtggaagga cgtggaccgc atcgtgggcc tggaccagat ggccaagatg acggagagct   2040

cgctgcccag cgcctccaag accaagaagg gcatgttccg cacagtgggg cagctgtaca   2100

aggagcagct gggcaagctg atgaccacgc tacgcaacac cacgcccaac ttcgtgcgct   2160

gcatcatccc caaccacgag aagaggtccg gcaagctgga tgcgttcctg gtgctggagc   2220

agctgcggtg caatggggtg ctggaaggca ttcgcatctg ccggcagggc ttccccaacc   2280

ggatcgtctt ccaggagttc cgccaacgct acgagatcct ggcggcgaat gccatcccca   2340

aaggcttcat ggacgggaag caggcctgca ttctcatgat caaagccctg gaacttgacc   2400

ccaacttata caggataggg cagagcaaaa tcttcttccg aactggcgtc ctggcccacc   2460

tagaggagga gcgagatttg aagatcaccg atgtcatcat ggccttccag gcgatgtgtc   2520

gtggctactt ggccagaaag gcttttgcca agaggcagca gcagctgacc gccatgaagg   2580

tgattcagag gaactgcgcc gcctacctca agctgcggaa ctggcagtgg tggaggcttt   2640

tcaccaaagt gaagccactg ctgcaggtga cacggcagga ggaggagatg caggccaagg   2700

aggatgaact gcagaagacc aaggagcggc agcagaaggc agagaatgag cttaaggagc   2760

tggaacagaa gcactcgcag ctgaccgagg agaagaacct gctacaggaa cagctgcagg   2820

cagagacaga gctgtatgca gaggctgagg agatgcgggt gcggctggcg gccaagaagc   2880

aggagctgga ggagatactg catgagatgg aggcccgcct ggaggaggag gaagacaggg   2940

gccagcagct acaggctgaa aggaagaaga tggcccagca gatgctggac cttgaagaac   3000

agctggagga ggaggaagct gccaggcaga agctgcaact tgagaaggtc acggctgagg   3060

ccaagatcaa gaaactggag gatgagatcc tggtcatgga tgatcagaac aataaactat   3120

caaaagaacg aaaactcctt gaggagagga ttagtgactt aacgacaaat cttgcagaag   3180

aggaagaaaa ggccaagaat cttaccaagc tgaaaaacaa gcatgaatct atgatttcag   3240

aactggaagt gcggctaaag aaggaagaga agagccgaca ggagctggag aagctgaaac   3300

ggaagctgga gggtgatgcc agcgacttcc acgagcagat cgctgacctc caggcgcaga   3360

tcgcagagct caagatgcag ctggccaaga aggaggagga gctgcaggcg gccctggcca   3420

ggcttgacga tgaaatcgct cagaagaaca atgccctgaa gaagatccgg gagctggagg   3480

gccacatctc agacctccag gaggacctgg actcagagcg ggccgccagg aacaaggctg   3540

aaaagcagaa gcgagacctc ggcgaggagc tggaggccct aaagacagag ctggaagaca   3600

cactggacag cacagccact cagcaggagc tcagggccaa gagggagcag gaggtgacgg   3660

tgctgaagaa ggccctggat gaagagacgc ggtcccatga ggctcaggtc caggagatga   3720

ggcagaaaca cgcacaggcg gtggaggagc tcacagagca gcttgagcag ttcaagaggg   3780

ccaaggcgaa cctagacaag aataagcaga cgctggagaa agagaacgca gacctggccg   3840

gggagctgcg ggtcctgggc caggccaagc aggaggtgga acataagaag aagaagctgg   3900

aggcgcaggt gcaggagctg cagtccaagt gcagcgatgg ggagcgggcc cgggcggagc   3960

tcaatgacaa agtccacaag ctgcagaatg aagttgagag cgtcacaggg atgcttaacg   4020

aggccgaggg gaaggccatt aagctggcca aggacgtggc gtccctcagt tcccagctcc   4080

aggacaccca ggagctgctt caagaagaaa cccggcagaa gctcaacgtg tctacgaagc   4140

tgcgccagct ggaggaggag cggaacagcc tgcaagacca gctggacgag gagatggagg   4200

ccaagcagaa cctggagcgc cacatctcca ctctcaacat ccagctctcc gactcgaaga   4260

agaagctgca ggactttgcc agcaccgtgg aagctctgga agaggggaag aagaggttcc   4320

agaaggagat cgagaacctc acccagcagt acgaggagaa ggcggccgct tatgataaac   4380

tggaaaagac caagaacagg cttcagcagg agctggacga cctggttgtt gatttggaca   4440

accagcggca actcgtgtcc aacctggaaa agaagcagag gaaatttgat cagttgttag   4500

ccgaggagaa aaacatctct tccaaatacg cggatgagag ggacagagct gaggcagaag   4560

ccagggagaa ggaaaccaag gccctgtccc tggctcgggc ccttgaagag gccttggaag   4620

ccaaagagga actcgagcgg accaacaaaa tgctcaaagc cgaaatggaa gacctggtca   4680

gctccaagga tgacgtgggc aagaacgtcc atgagctgga gaagtccaag cgggccctgg   4740

agacccagat ggaggagatg aagacgcagc tggaagagct ggaggacgag ctgcaagcca   4800

cggaggacgc caaactgcgg ctggaagtca acatgcaggc gctcaagggc cagttcgaaa   4860

gggatctcca agcccgggac gagcagaatg aggagaagag gaggcaactg cagagacagc   4920

ttcacgagta tgagacggaa ctggaagacg agcgaaagca acgtgccctg gcagctgcag   4980

caaagaagaa gctggaaggg gacctgaaag acctggagct tcaggccgac tctgccatca   5040

aggggaggga ggaagccatc aagcagctac gcaaactgca ggctcagatg aaggactttc   5100

aaagagagct ggaagatgcc cgtgcctcca gagatgagat ctttgccaca gccaaagaga   5160

atgagaagaa agccaagagc ttggaagcag acctcatgca gctacaagag gacctcgccg   5220

ccgctgagag ggctcgcaaa caagcggacc tcgagaagga ggaactggca gaggagctgg   5280

ccagtagcct gtcgggaagg aacgcactcc aggacgagaa gcgccgcctg gaggcccgga   5340

tcgcccagct ggaggaggag ctggaggagg agcagggcaa catggaggcc atgagcgacc   5400

gggtccgcaa agccacacag caggccgagc agctcagcaa cgagctggcc acagagcgca   5460

gcacggccca gaagaatgag agtgcccggc agcagctcga gcggcagaac aaggagctcc   5520

ggagcaagct ccacgagatg gagggggccg tcaagtccaa gttcaagtcc accatcgcgg   5580

cgctggaggc caagattgca cagctggagg agcaggtcga gcaggaggcc agagagaaac   5640

aggcggccac caagtcgctg aagcagaaag acaagaagct gaaggaaatc ttgctgcagg   5700

tggaggacga gcgcaagatg gccgagcagt acaaggagca ggcagagaaa ggcaatgcca   5760

gggtcaagca gctcaagagg cagctggagg aggcagagga ggagtcccag cgcatcaacg   5820

ccaaccgcag gaagctgcag cgggagctgg atgaggccac ggagagcaac gaggccatgg   5880

gccgcgaggt gaacgcactc aagagcaagc tcaggcgagg aaacgagacc tctttcgttc   5940

cttctagaag gtctggagga cgtagagtta ttgaaaatgc agatggttct gaggaggaaa   6000

cggacactcg agacgcagac ttcaatggaa ccaaggccag tgaataagca actttctaca   6060

gttttgcacc acggcaagaa aaccaaaaac caaaacaaac aaacaaaaaa aacccaacaa   6120

caacccagaa caaagcaaaa cccagcagac tgtacttagc attgtctaaa tccattctca   6180

aattccaaat atcacagaca cccctcacac aaggaatata aaaaccacca ccctccagcc   6240

tgggcaacgt agtaaaacct catctataca agaatttaaa aataagctgg gcgtggtggt   6300

acacacctgt ggtcccagct actagggagg ctgagccagg aagaacgctc cagcccagga   6360

cttcgaggct gcaatgagct ataattgcat cattgcactc cagcctgggc aacagagacc   6420

ctgtctcaac caccaccacc accaccaccc ctactacccc tgtattcaag gtaaaaattg   6480

aagtttgtat gatgtaagag atgagaaaaa cccaacagga aacacagaca catcctccag   6540

ttctatcaat ggattgtgca gacactgagt ttttagaaaa acatatccac ggtaaccggt   6600

ccctggcaat tctgtttaca tgaaatgggg agaaagtcac cgaaatgggt gccgccggcc   6660

cccactccca attcattccc taacctgcaa acctttccaa cttctcacgt caggcctttg   6720

agaattcttt ccccctctcc tggtttccac acctcagaca cgcacagttc accaagtgcc   6780

ttctgtagtc acatgaattg aaaaggagac gctgctccca cggaggggag caggaatgct   6840

gcactgttta caccctgact gtgcttaaaa acactttcac taataaatgg ttataaatca   6900

caa                                                                 6903


<210>  1088
<211>  1979
<212>  PRT
<213>  Homo sapiens

<400>  1088

Met Ala Gln Lys Gly Gln Leu Ser Asp Asp Glu Lys Phe Leu Phe Val 
1               5                   10                  15


Asp Lys Asn Phe Ile Asn Ser Pro Val Ala Gln Ala Asp Trp Ala Ala 
            20                  25                  30


Lys Arg Leu Val Trp Val Pro Ser Glu Lys Gln Gly Phe Glu Ala Ala 
        35                  40                  45


Ser Ile Lys Glu Glu Lys Gly Asp Glu Val Val Val Glu Leu Val Glu 
    50                  55                  60


Asn Gly Lys Lys Val Thr Val Gly Lys Asp Asp Ile Gln Lys Met Asn 
65                  70                  75                  80


Pro Pro Lys Phe Ser Lys Val Glu Asp Met Ala Glu Leu Thr Cys Leu 
                85                  90                  95


Asn Glu Ala Ser Val Leu His Asn Leu Arg Glu Arg Tyr Phe Ser Gly 
            100                 105                 110


Leu Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Val Val Asn Pro Tyr 
        115                 120                 125


Lys His Leu Pro Ile Tyr Ser Glu Lys Ile Val Asp Met Tyr Lys Gly 
    130                 135                 140


Lys Lys Arg His Glu Met Pro Pro His Ile Tyr Ala Ile Ala Asp Thr 
145                 150                 155                 160


Ala Tyr Arg Ser Met Leu Gln Asp Arg Glu Asp Gln Ser Ile Leu Cys 
                165                 170                 175


Thr Gly Glu Ser Gly Ala Gly Lys Thr Glu Asn Thr Lys Lys Val Ile 
            180                 185                 190


Gln Tyr Leu Ala Val Val Ala Ser Ser His Lys Gly Lys Lys Asp Thr 
        195                 200                 205


Ser Ile Thr Gln Gly Pro Ser Phe Ala Tyr Gly Glu Leu Glu Lys Gln 
    210                 215                 220


Leu Leu Gln Ala Asn Pro Ile Leu Glu Ala Phe Gly Asn Ala Lys Thr 
225                 230                 235                 240


Val Lys Asn Asp Asn Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile Asn 
                245                 250                 255


Phe Asp Val Thr Gly Tyr Ile Val Gly Ala Asn Ile Glu Thr Tyr Leu 
            260                 265                 270


Leu Glu Lys Ser Arg Ala Ile Arg Gln Ala Arg Asp Glu Arg Thr Phe 
        275                 280                 285


His Ile Phe Tyr Tyr Met Ile Ala Gly Ala Lys Glu Lys Met Arg Ser 
    290                 295                 300


Asp Leu Leu Leu Glu Gly Phe Asn Asn Tyr Thr Phe Leu Ser Asn Gly 
305                 310                 315                 320


Phe Val Pro Ile Pro Ala Ala Gln Asp Asp Glu Met Phe Gln Glu Thr 
                325                 330                 335


Val Glu Ala Met Ala Ile Met Gly Phe Ser Glu Glu Glu Gln Leu Ser 
            340                 345                 350


Ile Leu Lys Val Val Ser Ser Val Leu Gln Leu Gly Asn Ile Val Phe 
        355                 360                 365


Lys Lys Glu Arg Asn Thr Asp Gln Ala Ser Met Pro Asp Asn Thr Ala 
    370                 375                 380


Ala Gln Lys Val Cys His Leu Met Gly Ile Asn Val Thr Asp Phe Thr 
385                 390                 395                 400


Arg Ser Ile Leu Thr Pro Arg Ile Lys Val Gly Arg Asp Val Val Gln 
                405                 410                 415


Lys Ala Gln Thr Lys Glu Gln Ala Asp Phe Ala Val Glu Ala Leu Ala 
            420                 425                 430


Lys Ala Thr Tyr Glu Arg Leu Phe Arg Trp Ile Leu Thr Arg Val Asn 
        435                 440                 445


Lys Ala Leu Asp Lys Thr His Arg Gln Gly Ala Ser Phe Leu Gly Ile 
    450                 455                 460


Leu Asp Ile Ala Gly Phe Glu Ile Phe Glu Val Asn Ser Phe Glu Gln 
465                 470                 475                 480


Leu Cys Ile Asn Tyr Thr Asn Glu Lys Leu Gln Gln Leu Phe Asn His 
                485                 490                 495


Thr Met Phe Ile Leu Glu Gln Glu Glu Tyr Gln Arg Glu Gly Ile Glu 
            500                 505                 510


Trp Asn Phe Ile Asp Phe Gly Leu Asp Leu Gln Pro Cys Ile Glu Leu 
        515                 520                 525


Ile Glu Arg Pro Asn Asn Pro Pro Gly Val Leu Ala Leu Leu Asp Glu 
    530                 535                 540


Glu Cys Trp Phe Pro Lys Ala Thr Asp Lys Ser Phe Val Glu Lys Leu 
545                 550                 555                 560


Cys Thr Glu Gln Gly Ser His Pro Lys Phe Gln Lys Pro Lys Gln Leu 
                565                 570                 575


Lys Asp Lys Thr Glu Phe Ser Ile Ile His Tyr Ala Gly Lys Val Asp 
            580                 585                 590


Tyr Asn Ala Ser Ala Trp Leu Thr Lys Asn Met Asp Pro Leu Asn Asp 
        595                 600                 605


Asn Val Thr Ser Leu Leu Asn Ala Ser Ser Asp Lys Phe Val Ala Asp 
    610                 615                 620


Leu Trp Lys Asp Val Asp Arg Ile Val Gly Leu Asp Gln Met Ala Lys 
625                 630                 635                 640


Met Thr Glu Ser Ser Leu Pro Ser Ala Ser Lys Thr Lys Lys Gly Met 
                645                 650                 655


Phe Arg Thr Val Gly Gln Leu Tyr Lys Glu Gln Leu Gly Lys Leu Met 
            660                 665                 670


Thr Thr Leu Arg Asn Thr Thr Pro Asn Phe Val Arg Cys Ile Ile Pro 
        675                 680                 685


Asn His Glu Lys Arg Ser Gly Lys Leu Asp Ala Phe Leu Val Leu Glu 
    690                 695                 700


Gln Leu Arg Cys Asn Gly Val Leu Glu Gly Ile Arg Ile Cys Arg Gln 
705                 710                 715                 720


Gly Phe Pro Asn Arg Ile Val Phe Gln Glu Phe Arg Gln Arg Tyr Glu 
                725                 730                 735


Ile Leu Ala Ala Asn Ala Ile Pro Lys Gly Phe Met Asp Gly Lys Gln 
            740                 745                 750


Ala Cys Ile Leu Met Ile Lys Ala Leu Glu Leu Asp Pro Asn Leu Tyr 
        755                 760                 765


Arg Ile Gly Gln Ser Lys Ile Phe Phe Arg Thr Gly Val Leu Ala His 
    770                 775                 780


Leu Glu Glu Glu Arg Asp Leu Lys Ile Thr Asp Val Ile Met Ala Phe 
785                 790                 795                 800


Gln Ala Met Cys Arg Gly Tyr Leu Ala Arg Lys Ala Phe Ala Lys Arg 
                805                 810                 815


Gln Gln Gln Leu Thr Ala Met Lys Val Ile Gln Arg Asn Cys Ala Ala 
            820                 825                 830


Tyr Leu Lys Leu Arg Asn Trp Gln Trp Trp Arg Leu Phe Thr Lys Val 
        835                 840                 845


Lys Pro Leu Leu Gln Val Thr Arg Gln Glu Glu Glu Met Gln Ala Lys 
    850                 855                 860


Glu Asp Glu Leu Gln Lys Thr Lys Glu Arg Gln Gln Lys Ala Glu Asn 
865                 870                 875                 880


Glu Leu Lys Glu Leu Glu Gln Lys His Ser Gln Leu Thr Glu Glu Lys 
                885                 890                 895


Asn Leu Leu Gln Glu Gln Leu Gln Ala Glu Thr Glu Leu Tyr Ala Glu 
            900                 905                 910


Ala Glu Glu Met Arg Val Arg Leu Ala Ala Lys Lys Gln Glu Leu Glu 
        915                 920                 925


Glu Ile Leu His Glu Met Glu Ala Arg Leu Glu Glu Glu Glu Asp Arg 
    930                 935                 940


Gly Gln Gln Leu Gln Ala Glu Arg Lys Lys Met Ala Gln Gln Met Leu 
945                 950                 955                 960


Asp Leu Glu Glu Gln Leu Glu Glu Glu Glu Ala Ala Arg Gln Lys Leu 
                965                 970                 975


Gln Leu Glu Lys Val Thr Ala Glu Ala Lys Ile Lys Lys Leu Glu Asp 
            980                 985                 990


Glu Ile Leu Val Met Asp Asp Gln Asn Asn Lys Leu Ser Lys Glu Arg 
        995                 1000                1005


Lys Leu Leu Glu Glu Arg Ile Ser Asp Leu Thr Thr Asn Leu Ala Glu 
    1010                1015                1020


Glu Glu Glu Lys Ala Lys Asn Leu Thr Lys Leu Lys Asn Lys His Glu 
1025                1030                1035                1040


Ser Met Ile Ser Glu Leu Glu Val Arg Leu Lys Lys Glu Glu Lys Ser 
                1045                1050                1055


Arg Gln Glu Leu Glu Lys Leu Lys Arg Lys Leu Glu Gly Asp Ala Ser 
            1060                1065                1070


Asp Phe His Glu Gln Ile Ala Asp Leu Gln Ala Gln Ile Ala Glu Leu 
        1075                1080                1085


Lys Met Gln Leu Ala Lys Lys Glu Glu Glu Leu Gln Ala Ala Leu Ala 
    1090                1095                1100


Arg Leu Asp Asp Glu Ile Ala Gln Lys Asn Asn Ala Leu Lys Lys Ile 
1105                1110                1115                1120


Arg Glu Leu Glu Gly His Ile Ser Asp Leu Gln Glu Asp Leu Asp Ser 
                1125                1130                1135


Glu Arg Ala Ala Arg Asn Lys Ala Glu Lys Gln Lys Arg Asp Leu Gly 
            1140                1145                1150


Glu Glu Leu Glu Ala Leu Lys Thr Glu Leu Glu Asp Thr Leu Asp Ser 
        1155                1160                1165


Thr Ala Thr Gln Gln Glu Leu Arg Ala Lys Arg Glu Gln Glu Val Thr 
    1170                1175                1180


Val Leu Lys Lys Ala Leu Asp Glu Glu Thr Arg Ser His Glu Ala Gln 
1185                1190                1195                1200


Val Gln Glu Met Arg Gln Lys His Ala Gln Ala Val Glu Glu Leu Thr 
                1205                1210                1215


Glu Gln Leu Glu Gln Phe Lys Arg Ala Lys Ala Asn Leu Asp Lys Asn 
            1220                1225                1230


Lys Gln Thr Leu Glu Lys Glu Asn Ala Asp Leu Ala Gly Glu Leu Arg 
        1235                1240                1245


Val Leu Gly Gln Ala Lys Gln Glu Val Glu His Lys Lys Lys Lys Leu 
    1250                1255                1260


Glu Ala Gln Val Gln Glu Leu Gln Ser Lys Cys Ser Asp Gly Glu Arg 
1265                1270                1275                1280


Ala Arg Ala Glu Leu Asn Asp Lys Val His Lys Leu Gln Asn Glu Val 
                1285                1290                1295


Glu Ser Val Thr Gly Met Leu Asn Glu Ala Glu Gly Lys Ala Ile Lys 
            1300                1305                1310


Leu Ala Lys Asp Val Ala Ser Leu Ser Ser Gln Leu Gln Asp Thr Gln 
        1315                1320                1325


Glu Leu Leu Gln Glu Glu Thr Arg Gln Lys Leu Asn Val Ser Thr Lys 
    1330                1335                1340


Leu Arg Gln Leu Glu Glu Glu Arg Asn Ser Leu Gln Asp Gln Leu Asp 
1345                1350                1355                1360


Glu Glu Met Glu Ala Lys Gln Asn Leu Glu Arg His Ile Ser Thr Leu 
                1365                1370                1375


Asn Ile Gln Leu Ser Asp Ser Lys Lys Lys Leu Gln Asp Phe Ala Ser 
            1380                1385                1390


Thr Val Glu Ala Leu Glu Glu Gly Lys Lys Arg Phe Gln Lys Glu Ile 
        1395                1400                1405


Glu Asn Leu Thr Gln Gln Tyr Glu Glu Lys Ala Ala Ala Tyr Asp Lys 
    1410                1415                1420


Leu Glu Lys Thr Lys Asn Arg Leu Gln Gln Glu Leu Asp Asp Leu Val 
1425                1430                1435                1440


Val Asp Leu Asp Asn Gln Arg Gln Leu Val Ser Asn Leu Glu Lys Lys 
                1445                1450                1455


Gln Arg Lys Phe Asp Gln Leu Leu Ala Glu Glu Lys Asn Ile Ser Ser 
            1460                1465                1470


Lys Tyr Ala Asp Glu Arg Asp Arg Ala Glu Ala Glu Ala Arg Glu Lys 
        1475                1480                1485


Glu Thr Lys Ala Leu Ser Leu Ala Arg Ala Leu Glu Glu Ala Leu Glu 
    1490                1495                1500


Ala Lys Glu Glu Leu Glu Arg Thr Asn Lys Met Leu Lys Ala Glu Met 
1505                1510                1515                1520


Glu Asp Leu Val Ser Ser Lys Asp Asp Val Gly Lys Asn Val His Glu 
                1525                1530                1535


Leu Glu Lys Ser Lys Arg Ala Leu Glu Thr Gln Met Glu Glu Met Lys 
            1540                1545                1550


Thr Gln Leu Glu Glu Leu Glu Asp Glu Leu Gln Ala Thr Glu Asp Ala 
        1555                1560                1565


Lys Leu Arg Leu Glu Val Asn Met Gln Ala Leu Lys Gly Gln Phe Glu 
    1570                1575                1580


Arg Asp Leu Gln Ala Arg Asp Glu Gln Asn Glu Glu Lys Arg Arg Gln 
1585                1590                1595                1600


Leu Gln Arg Gln Leu His Glu Tyr Glu Thr Glu Leu Glu Asp Glu Arg 
                1605                1610                1615


Lys Gln Arg Ala Leu Ala Ala Ala Ala Lys Lys Lys Leu Glu Gly Asp 
            1620                1625                1630


Leu Lys Asp Leu Glu Leu Gln Ala Asp Ser Ala Ile Lys Gly Arg Glu 
        1635                1640                1645


Glu Ala Ile Lys Gln Leu Arg Lys Leu Gln Ala Gln Met Lys Asp Phe 
    1650                1655                1660


Gln Arg Glu Leu Glu Asp Ala Arg Ala Ser Arg Asp Glu Ile Phe Ala 
1665                1670                1675                1680


Thr Ala Lys Glu Asn Glu Lys Lys Ala Lys Ser Leu Glu Ala Asp Leu 
                1685                1690                1695


Met Gln Leu Gln Glu Asp Leu Ala Ala Ala Glu Arg Ala Arg Lys Gln 
            1700                1705                1710


Ala Asp Leu Glu Lys Glu Glu Leu Ala Glu Glu Leu Ala Ser Ser Leu 
        1715                1720                1725


Ser Gly Arg Asn Ala Leu Gln Asp Glu Lys Arg Arg Leu Glu Ala Arg 
    1730                1735                1740


Ile Ala Gln Leu Glu Glu Glu Leu Glu Glu Glu Gln Gly Asn Met Glu 
1745                1750                1755                1760


Ala Met Ser Asp Arg Val Arg Lys Ala Thr Gln Gln Ala Glu Gln Leu 
                1765                1770                1775


Ser Asn Glu Leu Ala Thr Glu Arg Ser Thr Ala Gln Lys Asn Glu Ser 
            1780                1785                1790


Ala Arg Gln Gln Leu Glu Arg Gln Asn Lys Glu Leu Arg Ser Lys Leu 
        1795                1800                1805


His Glu Met Glu Gly Ala Val Lys Ser Lys Phe Lys Ser Thr Ile Ala 
    1810                1815                1820


Ala Leu Glu Ala Lys Ile Ala Gln Leu Glu Glu Gln Val Glu Gln Glu 
1825                1830                1835                1840


Ala Arg Glu Lys Gln Ala Ala Thr Lys Ser Leu Lys Gln Lys Asp Lys 
                1845                1850                1855


Lys Leu Lys Glu Ile Leu Leu Gln Val Glu Asp Glu Arg Lys Met Ala 
            1860                1865                1870


Glu Gln Tyr Lys Glu Gln Ala Glu Lys Gly Asn Ala Arg Val Lys Gln 
        1875                1880                1885


Leu Lys Arg Gln Leu Glu Glu Ala Glu Glu Glu Ser Gln Arg Ile Asn 
    1890                1895                1900


Ala Asn Arg Arg Lys Leu Gln Arg Glu Leu Asp Glu Ala Thr Glu Ser 
1905                1910                1915                1920


Asn Glu Ala Met Gly Arg Glu Val Asn Ala Leu Lys Ser Lys Leu Arg 
                1925                1930                1935


Arg Gly Asn Glu Thr Ser Phe Val Pro Ser Arg Arg Ser Gly Gly Arg 
            1940                1945                1950


Arg Val Ile Glu Asn Ala Asp Gly Ser Glu Glu Glu Thr Asp Thr Arg 
        1955                1960                1965


Asp Ala Asp Phe Asn Gly Thr Lys Ala Ser Glu 
    1970                1975


<210>  1089
<211>  6882
<212>  DNA
<213>  Homo sapiens

<400>  1089
gggagatttg gacgctccgg cctgggaggt gcgtcagatc cgagctcgcc atccagtttc     60

ctctccacta gtccccccag ttggagatct gggaccaaca aggcaccatg gcgcagaagg    120

gccaactcag tgacgatgag aagttcctct ttgtggacaa aaacttcatc aacagcccag    180

tggcccaggc tgactgggcc gccaagagac tcgtctgggt cccctcggag aagcagggct    240

tcgaggcagc cagcattaag gaggagaagg gggatgaggt ggttgtggag ctggtggaga    300

atggcaagaa ggtcacggtt gggaaagatg acatccagaa gatgaaccca cccaagttct    360

ccaaggtgga ggacatggcg gagctgacgt gcctcaacga agcctccgtg ctacacaacc    420

tgagggagcg gtacttctca gggctaatat atacgtactc tggcctcttc tgcgtggtgg    480

tcaaccccta taaacacctg cccatctact cggagaagat cgtcgacatg tacaagggca    540

agaagaggca cgagatgccg cctcacatct acgccatcgc agacacggcc taccggagca    600

tgcttcaaga tcgggaggac cagtccattc tatgcacagg cgagtctgga gccgggaaaa    660

ccgaaaacac caagaaggtc attcagtacc tggccgtggt ggcctcctcc cacaagggca    720

agaaagacac aagtatcacg ggagagctgg aaaagcagct tctacaagca aacccgattc    780

tggaggcttt cggcaacgcc aaaacagtga agaacgacaa ctcctcacga ttcggcaaat    840

tcatccgcat caacttcgac gtcacgggtt acatcgtggg agccaacatt gagacctatc    900

tgctagaaaa atcacgggca attcgccaag ccagagacga gaggacattc cacatctttt    960

actacatgat tgctggagcc aaggagaaga tgagaagtga cttgcttttg gagggcttca   1020

acaactacac cttcctctcc aatggctttg tgcccatccc agcagcccag gatgatgaga   1080

tgttccagga aaccgtggag gccatggcaa tcatgggttt cagcgaggag gagcagctat   1140

ccatattgaa ggtggtatca tcggtcctgc agcttggaaa tatcgtcttc aagaaggaaa   1200

gaaacacaga ccaggcgtcc atgccagata acacagctgc tcagaaagtt tgccacctca   1260

tgggaattaa tgtgacagat ttcaccagat ccatcctcac tcctcgtatc aaggttgggc   1320

gagatgtggt acagaaagct cagacaaaag aacaggctga ctttgctgta gaggctttgg   1380

ccaaggcaac atatgagcgc cttttccgct ggatactcac ccgcgtgaac aaagccctgg   1440

acaagaccca tcggcaaggg gcttccttcc tggggatcct ggatatagct ggatttgaga   1500

tctttgaggt gaactccttc gagcagctgt gcatcaacta caccaacgag aagctgcagc   1560

agctcttcaa ccacaccatg ttcatcctgg agcaggagga gtaccagcgc gagggcatcg   1620

agtggaactt catcgacttt gggctggacc tacagccctg catcgagctc atcgagcgac   1680

cgaacaaccc tccaggtgtg ctggccctgc tggacgagga atgctggttc cccaaagcca   1740

cggacaagtc tttcgtggag aagctgtgca cggagcaggg cagccacccc aagttccaga   1800

agcccaagca gctcaaggac aagactgagt tctccatcat ccattatgct gggaaggtgg   1860

actataatgc gagtgcctgg ctgaccaaga atatggaccc gctgaatgac aacgtgactt   1920

ccctgctcaa tgcctcctcc gacaagtttg tggccgacct gtggaaggac gtggaccgca   1980

tcgtgggcct ggaccagatg gccaagatga cggagagctc gctgcccagc gcctccaaga   2040

ccaagaaggg catgttccgc acagtggggc agctgtacaa ggagcagctg ggcaagctga   2100

tgaccacgct acgcaacacc acgcccaact tcgtgcgctg catcatcccc aaccacgaga   2160

agaggtccgg caagctggat gcgttcctgg tgctggagca gctgcggtgc aatggggtgc   2220

tggaaggcat tcgcatctgc cggcagggct tccccaaccg gatcgtcttc caggagttcc   2280

gccaacgcta cgagatcctg gcggcgaatg ccatccccaa aggcttcatg gacgggaagc   2340

aggcctgcat tctcatgatc aaagccctgg aacttgaccc caacttatac aggatagggc   2400

agagcaaaat cttcttccga actggcgtcc tggcccacct agaggaggag cgagatttga   2460

agatcaccga tgtcatcatg gccttccagg cgatgtgtcg tggctacttg gccagaaagg   2520

cttttgccaa gaggcagcag cagctgaccg ccatgaaggt gattcagagg aactgcgccg   2580

cctacctcaa gctgcggaac tggcagtggt ggaggctttt caccaaagtg aagccactgc   2640

tgcaggtgac acggcaggag gaggagatgc aggccaagga ggatgaactg cagaagacca   2700

aggagcggca gcagaaggca gagaatgagc ttaaggagct ggaacagaag cactcgcagc   2760

tgaccgagga gaagaacctg ctacaggaac agctgcaggc agagacagag ctgtatgcag   2820

aggctgagga gatgcgggtg cggctggcgg ccaagaagca ggagctggag gagatactgc   2880

atgagatgga ggcccgcctg gaggaggagg aagacagggg ccagcagcta caggctgaaa   2940

ggaagaagat ggcccagcag atgctggacc ttgaagaaca gctggaggag gaggaagctg   3000

ccaggcagaa gctgcaactt gagaaggtca cggctgaggc caagatcaag aaactggagg   3060

atgagatcct ggtcatggat gatcagaaca ataaactatc aaaagaacga aaactccttg   3120

aggagaggat tagtgactta acgacaaatc ttgcagaaga ggaagaaaag gccaagaatc   3180

ttaccaagct gaaaaacaag catgaatcta tgatttcaga actggaagtg cggctaaaga   3240

aggaagagaa gagccgacag gagctggaga agctgaaacg gaagctggag ggtgatgcca   3300

gcgacttcca cgagcagatc gctgacctcc aggcgcagat cgcagagctc aagatgcagc   3360

tggccaagaa ggaggaggag ctgcaggcgg ccctggccag gcttgacgat gaaatcgctc   3420

agaagaacaa tgccctgaag aagatccggg agctggaggg ccacatctca gacctccagg   3480

aggacctgga ctcagagcgg gccgccagga acaaggctga aaagcagaag cgagacctcg   3540

gcgaggagct ggaggcccta aagacagagc tggaagacac actggacagc acagccactc   3600

agcaggagct cagggccaag agggagcagg aggtgacggt gctgaagaag gccctggatg   3660

aagagacgcg gtcccatgag gctcaggtcc aggagatgag gcagaaacac gcacaggcgg   3720

tggaggagct cacagagcag cttgagcagt tcaagagggc caaggcgaac ctagacaaga   3780

ataagcagac gctggagaaa gagaacgcag acctggccgg ggagctgcgg gtcctgggcc   3840

aggccaagca ggaggtggaa cataagaaga agaagctgga ggcgcaggtg caggagctgc   3900

agtccaagtg cagcgatggg gagcgggccc gggcggagct caatgacaaa gtccacaagc   3960

tgcagaatga agttgagagc gtcacaggga tgcttaacga ggccgagggg aaggccatta   4020

agctggccaa ggacgtggcg tccctcagtt cccagctcca ggacacccag gagctgcttc   4080

aagaagaaac ccggcagaag ctcaacgtgt ctacgaagct gcgccagctg gaggaggagc   4140

ggaacagcct gcaagaccag ctggacgagg agatggaggc caagcagaac ctggagcgcc   4200

acatctccac tctcaacatc cagctctccg actcgaagaa gaagctgcag gactttgcca   4260

gcaccgtgga agctctggaa gaggggaaga agaggttcca gaaggagatc gagaacctca   4320

cccagcagta cgaggagaag gcggccgctt atgataaact ggaaaagacc aagaacaggc   4380

ttcagcagga gctggacgac ctggttgttg atttggacaa ccagcggcaa ctcgtgtcca   4440

acctggaaaa gaagcagagg aaatttgatc agttgttagc cgaggagaaa aacatctctt   4500

ccaaatacgc ggatgagagg gacagagctg aggcagaagc cagggagaag gaaaccaagg   4560

ccctgtccct ggctcgggcc cttgaagagg ccttggaagc caaagaggaa ctcgagcgga   4620

ccaacaaaat gctcaaagcc gaaatggaag acctggtcag ctccaaggat gacgtgggca   4680

agaacgtcca tgagctggag aagtccaagc gggccctgga gacccagatg gaggagatga   4740

agacgcagct ggaagagctg gaggacgagc tgcaagccac ggaggacgcc aaactgcggc   4800

tggaagtcaa catgcaggcg ctcaagggcc agttcgaaag ggatctccaa gcccgggacg   4860

agcagaatga ggagaagagg aggcaactgc agagacagct tcacgagtat gagacggaac   4920

tggaagacga gcgaaagcaa cgtgccctgg cagctgcagc aaagaagaag ctggaagggg   4980

acctgaaaga cctggagctt caggccgact ctgccatcaa ggggagggag gaagccatca   5040

agcagctacg caaactgcag gctcagatga aggactttca aagagagctg gaagatgccc   5100

gtgcctccag agatgagatc tttgccacag ccaaagagaa tgagaagaaa gccaagagct   5160

tggaagcaga cctcatgcag ctacaagagg acctcgccgc cgctgagagg gctcgcaaac   5220

aagcggacct cgagaaggag gaactggcag aggagctggc cagtagcctg tcgggaagga   5280

acgcactcca ggacgagaag cgccgcctgg aggcccggat cgcccagctg gaggaggagc   5340

tggaggagga gcagggcaac atggaggcca tgagcgaccg ggtccgcaaa gccacacagc   5400

aggccgagca gctcagcaac gagctggcca cagagcgcag cacggcccag aagaatgaga   5460

gtgcccggca gcagctcgag cggcagaaca aggagctccg gagcaagctc cacgagatgg   5520

agggggccgt caagtccaag ttcaagtcca ccatcgcggc gctggaggcc aagattgcac   5580

agctggagga gcaggtcgag caggaggcca gagagaaaca ggcggccacc aagtcgctga   5640

agcagaaaga caagaagctg aaggaaatct tgctgcaggt ggaggacgag cgcaagatgg   5700

ccgagcagta caaggagcag gcagagaaag gcaatgccag ggtcaagcag ctcaagaggc   5760

agctggagga ggcagaggag gagtcccagc gcatcaacgc caaccgcagg aagctgcagc   5820

gggagctgga tgaggccacg gagagcaacg aggccatggg ccgcgaggtg aacgcactca   5880

agagcaagct caggcgagga aacgagacct ctttcgttcc ttctagaagg tctggaggac   5940

gtagagttat tgaaaatgca gatggttctg aggaggaaac ggacactcga gacgcagact   6000

tcaatggaac caaggccagt gaataagcaa ctttctacag ttttgcacca cggcaagaaa   6060

accaaaaacc aaaacaaaca aacaaaaaaa acccaacaac aacccagaac aaagcaaaac   6120

ccagcagact gtacttagca ttgtctaaat ccattctcaa attccaaata tcacagacac   6180

ccctcacaca aggaatataa aaaccaccac cctccagcct gggcaacgta gtaaaacctc   6240

atctatacaa gaatttaaaa ataagctggg cgtggtggta cacacctgtg gtcccagcta   6300

ctagggaggc tgagccagga agaacgctcc agcccaggac ttcgaggctg caatgagcta   6360

taattgcatc attgcactcc agcctgggca acagagaccc tgtctcaacc accaccacca   6420

ccaccacccc tactacccct gtattcaagg taaaaattga agtttgtatg atgtaagaga   6480

tgagaaaaac ccaacaggaa acacagacac atcctccagt tctatcaatg gattgtgcag   6540

acactgagtt tttagaaaaa catatccacg gtaaccggtc cctggcaatt ctgtttacat   6600

gaaatgggga gaaagtcacc gaaatgggtg ccgccggccc ccactcccaa ttcattccct   6660

aacctgcaaa cctttccaac ttctcacgtc aggcctttga gaattctttc cccctctcct   6720

ggtttccaca cctcagacac gcacagttca ccaagtgcct tctgtagtca catgaattga   6780

aaaggagacg ctgctcccac ggaggggagc aggaatgctg cactgtttac accctgactg   6840

tgcttaaaaa cactttcact aataaatggt tataaatcac aa                      6882


<210>  1090
<211>  1972
<212>  PRT
<213>  Homo sapiens

<400>  1090

Met Ala Gln Lys Gly Gln Leu Ser Asp Asp Glu Lys Phe Leu Phe Val 
1               5                   10                  15


Asp Lys Asn Phe Ile Asn Ser Pro Val Ala Gln Ala Asp Trp Ala Ala 
            20                  25                  30


Lys Arg Leu Val Trp Val Pro Ser Glu Lys Gln Gly Phe Glu Ala Ala 
        35                  40                  45


Ser Ile Lys Glu Glu Lys Gly Asp Glu Val Val Val Glu Leu Val Glu 
    50                  55                  60


Asn Gly Lys Lys Val Thr Val Gly Lys Asp Asp Ile Gln Lys Met Asn 
65                  70                  75                  80


Pro Pro Lys Phe Ser Lys Val Glu Asp Met Ala Glu Leu Thr Cys Leu 
                85                  90                  95


Asn Glu Ala Ser Val Leu His Asn Leu Arg Glu Arg Tyr Phe Ser Gly 
            100                 105                 110


Leu Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Val Val Asn Pro Tyr 
        115                 120                 125


Lys His Leu Pro Ile Tyr Ser Glu Lys Ile Val Asp Met Tyr Lys Gly 
    130                 135                 140


Lys Lys Arg His Glu Met Pro Pro His Ile Tyr Ala Ile Ala Asp Thr 
145                 150                 155                 160


Ala Tyr Arg Ser Met Leu Gln Asp Arg Glu Asp Gln Ser Ile Leu Cys 
                165                 170                 175


Thr Gly Glu Ser Gly Ala Gly Lys Thr Glu Asn Thr Lys Lys Val Ile 
            180                 185                 190


Gln Tyr Leu Ala Val Val Ala Ser Ser His Lys Gly Lys Lys Asp Thr 
        195                 200                 205


Ser Ile Thr Gly Glu Leu Glu Lys Gln Leu Leu Gln Ala Asn Pro Ile 
    210                 215                 220


Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Lys Asn Asp Asn Ser Ser 
225                 230                 235                 240


Arg Phe Gly Lys Phe Ile Arg Ile Asn Phe Asp Val Thr Gly Tyr Ile 
                245                 250                 255


Val Gly Ala Asn Ile Glu Thr Tyr Leu Leu Glu Lys Ser Arg Ala Ile 
            260                 265                 270


Arg Gln Ala Arg Asp Glu Arg Thr Phe His Ile Phe Tyr Tyr Met Ile 
        275                 280                 285


Ala Gly Ala Lys Glu Lys Met Arg Ser Asp Leu Leu Leu Glu Gly Phe 
    290                 295                 300


Asn Asn Tyr Thr Phe Leu Ser Asn Gly Phe Val Pro Ile Pro Ala Ala 
305                 310                 315                 320


Gln Asp Asp Glu Met Phe Gln Glu Thr Val Glu Ala Met Ala Ile Met 
                325                 330                 335


Gly Phe Ser Glu Glu Glu Gln Leu Ser Ile Leu Lys Val Val Ser Ser 
            340                 345                 350


Val Leu Gln Leu Gly Asn Ile Val Phe Lys Lys Glu Arg Asn Thr Asp 
        355                 360                 365


Gln Ala Ser Met Pro Asp Asn Thr Ala Ala Gln Lys Val Cys His Leu 
    370                 375                 380


Met Gly Ile Asn Val Thr Asp Phe Thr Arg Ser Ile Leu Thr Pro Arg 
385                 390                 395                 400


Ile Lys Val Gly Arg Asp Val Val Gln Lys Ala Gln Thr Lys Glu Gln 
                405                 410                 415


Ala Asp Phe Ala Val Glu Ala Leu Ala Lys Ala Thr Tyr Glu Arg Leu 
            420                 425                 430


Phe Arg Trp Ile Leu Thr Arg Val Asn Lys Ala Leu Asp Lys Thr His 
        435                 440                 445


Arg Gln Gly Ala Ser Phe Leu Gly Ile Leu Asp Ile Ala Gly Phe Glu 
    450                 455                 460


Ile Phe Glu Val Asn Ser Phe Glu Gln Leu Cys Ile Asn Tyr Thr Asn 
465                 470                 475                 480


Glu Lys Leu Gln Gln Leu Phe Asn His Thr Met Phe Ile Leu Glu Gln 
                485                 490                 495


Glu Glu Tyr Gln Arg Glu Gly Ile Glu Trp Asn Phe Ile Asp Phe Gly 
            500                 505                 510


Leu Asp Leu Gln Pro Cys Ile Glu Leu Ile Glu Arg Pro Asn Asn Pro 
        515                 520                 525


Pro Gly Val Leu Ala Leu Leu Asp Glu Glu Cys Trp Phe Pro Lys Ala 
    530                 535                 540


Thr Asp Lys Ser Phe Val Glu Lys Leu Cys Thr Glu Gln Gly Ser His 
545                 550                 555                 560


Pro Lys Phe Gln Lys Pro Lys Gln Leu Lys Asp Lys Thr Glu Phe Ser 
                565                 570                 575


Ile Ile His Tyr Ala Gly Lys Val Asp Tyr Asn Ala Ser Ala Trp Leu 
            580                 585                 590


Thr Lys Asn Met Asp Pro Leu Asn Asp Asn Val Thr Ser Leu Leu Asn 
        595                 600                 605


Ala Ser Ser Asp Lys Phe Val Ala Asp Leu Trp Lys Asp Val Asp Arg 
    610                 615                 620


Ile Val Gly Leu Asp Gln Met Ala Lys Met Thr Glu Ser Ser Leu Pro 
625                 630                 635                 640


Ser Ala Ser Lys Thr Lys Lys Gly Met Phe Arg Thr Val Gly Gln Leu 
                645                 650                 655


Tyr Lys Glu Gln Leu Gly Lys Leu Met Thr Thr Leu Arg Asn Thr Thr 
            660                 665                 670


Pro Asn Phe Val Arg Cys Ile Ile Pro Asn His Glu Lys Arg Ser Gly 
        675                 680                 685


Lys Leu Asp Ala Phe Leu Val Leu Glu Gln Leu Arg Cys Asn Gly Val 
    690                 695                 700


Leu Glu Gly Ile Arg Ile Cys Arg Gln Gly Phe Pro Asn Arg Ile Val 
705                 710                 715                 720


Phe Gln Glu Phe Arg Gln Arg Tyr Glu Ile Leu Ala Ala Asn Ala Ile 
                725                 730                 735


Pro Lys Gly Phe Met Asp Gly Lys Gln Ala Cys Ile Leu Met Ile Lys 
            740                 745                 750


Ala Leu Glu Leu Asp Pro Asn Leu Tyr Arg Ile Gly Gln Ser Lys Ile 
        755                 760                 765


Phe Phe Arg Thr Gly Val Leu Ala His Leu Glu Glu Glu Arg Asp Leu 
    770                 775                 780


Lys Ile Thr Asp Val Ile Met Ala Phe Gln Ala Met Cys Arg Gly Tyr 
785                 790                 795                 800


Leu Ala Arg Lys Ala Phe Ala Lys Arg Gln Gln Gln Leu Thr Ala Met 
                805                 810                 815


Lys Val Ile Gln Arg Asn Cys Ala Ala Tyr Leu Lys Leu Arg Asn Trp 
            820                 825                 830


Gln Trp Trp Arg Leu Phe Thr Lys Val Lys Pro Leu Leu Gln Val Thr 
        835                 840                 845


Arg Gln Glu Glu Glu Met Gln Ala Lys Glu Asp Glu Leu Gln Lys Thr 
    850                 855                 860


Lys Glu Arg Gln Gln Lys Ala Glu Asn Glu Leu Lys Glu Leu Glu Gln 
865                 870                 875                 880


Lys His Ser Gln Leu Thr Glu Glu Lys Asn Leu Leu Gln Glu Gln Leu 
                885                 890                 895


Gln Ala Glu Thr Glu Leu Tyr Ala Glu Ala Glu Glu Met Arg Val Arg 
            900                 905                 910


Leu Ala Ala Lys Lys Gln Glu Leu Glu Glu Ile Leu His Glu Met Glu 
        915                 920                 925


Ala Arg Leu Glu Glu Glu Glu Asp Arg Gly Gln Gln Leu Gln Ala Glu 
    930                 935                 940


Arg Lys Lys Met Ala Gln Gln Met Leu Asp Leu Glu Glu Gln Leu Glu 
945                 950                 955                 960


Glu Glu Glu Ala Ala Arg Gln Lys Leu Gln Leu Glu Lys Val Thr Ala 
                965                 970                 975


Glu Ala Lys Ile Lys Lys Leu Glu Asp Glu Ile Leu Val Met Asp Asp 
            980                 985                 990


Gln Asn Asn Lys Leu Ser Lys Glu Arg Lys Leu Leu Glu Glu Arg Ile 
        995                 1000                1005


Ser Asp Leu Thr Thr Asn Leu Ala Glu Glu Glu Glu Lys Ala Lys Asn 
    1010                1015                1020


Leu Thr Lys Leu Lys Asn Lys His Glu Ser Met Ile Ser Glu Leu Glu 
1025                1030                1035                1040


Val Arg Leu Lys Lys Glu Glu Lys Ser Arg Gln Glu Leu Glu Lys Leu 
                1045                1050                1055


Lys Arg Lys Leu Glu Gly Asp Ala Ser Asp Phe His Glu Gln Ile Ala 
            1060                1065                1070


Asp Leu Gln Ala Gln Ile Ala Glu Leu Lys Met Gln Leu Ala Lys Lys 
        1075                1080                1085


Glu Glu Glu Leu Gln Ala Ala Leu Ala Arg Leu Asp Asp Glu Ile Ala 
    1090                1095                1100


Gln Lys Asn Asn Ala Leu Lys Lys Ile Arg Glu Leu Glu Gly His Ile 
1105                1110                1115                1120


Ser Asp Leu Gln Glu Asp Leu Asp Ser Glu Arg Ala Ala Arg Asn Lys 
                1125                1130                1135


Ala Glu Lys Gln Lys Arg Asp Leu Gly Glu Glu Leu Glu Ala Leu Lys 
            1140                1145                1150


Thr Glu Leu Glu Asp Thr Leu Asp Ser Thr Ala Thr Gln Gln Glu Leu 
        1155                1160                1165


Arg Ala Lys Arg Glu Gln Glu Val Thr Val Leu Lys Lys Ala Leu Asp 
    1170                1175                1180


Glu Glu Thr Arg Ser His Glu Ala Gln Val Gln Glu Met Arg Gln Lys 
1185                1190                1195                1200


His Ala Gln Ala Val Glu Glu Leu Thr Glu Gln Leu Glu Gln Phe Lys 
                1205                1210                1215


Arg Ala Lys Ala Asn Leu Asp Lys Asn Lys Gln Thr Leu Glu Lys Glu 
            1220                1225                1230


Asn Ala Asp Leu Ala Gly Glu Leu Arg Val Leu Gly Gln Ala Lys Gln 
        1235                1240                1245


Glu Val Glu His Lys Lys Lys Lys Leu Glu Ala Gln Val Gln Glu Leu 
    1250                1255                1260


Gln Ser Lys Cys Ser Asp Gly Glu Arg Ala Arg Ala Glu Leu Asn Asp 
1265                1270                1275                1280


Lys Val His Lys Leu Gln Asn Glu Val Glu Ser Val Thr Gly Met Leu 
                1285                1290                1295


Asn Glu Ala Glu Gly Lys Ala Ile Lys Leu Ala Lys Asp Val Ala Ser 
            1300                1305                1310


Leu Ser Ser Gln Leu Gln Asp Thr Gln Glu Leu Leu Gln Glu Glu Thr 
        1315                1320                1325


Arg Gln Lys Leu Asn Val Ser Thr Lys Leu Arg Gln Leu Glu Glu Glu 
    1330                1335                1340


Arg Asn Ser Leu Gln Asp Gln Leu Asp Glu Glu Met Glu Ala Lys Gln 
1345                1350                1355                1360


Asn Leu Glu Arg His Ile Ser Thr Leu Asn Ile Gln Leu Ser Asp Ser 
                1365                1370                1375


Lys Lys Lys Leu Gln Asp Phe Ala Ser Thr Val Glu Ala Leu Glu Glu 
            1380                1385                1390


Gly Lys Lys Arg Phe Gln Lys Glu Ile Glu Asn Leu Thr Gln Gln Tyr 
        1395                1400                1405


Glu Glu Lys Ala Ala Ala Tyr Asp Lys Leu Glu Lys Thr Lys Asn Arg 
    1410                1415                1420


Leu Gln Gln Glu Leu Asp Asp Leu Val Val Asp Leu Asp Asn Gln Arg 
1425                1430                1435                1440


Gln Leu Val Ser Asn Leu Glu Lys Lys Gln Arg Lys Phe Asp Gln Leu 
                1445                1450                1455


Leu Ala Glu Glu Lys Asn Ile Ser Ser Lys Tyr Ala Asp Glu Arg Asp 
            1460                1465                1470


Arg Ala Glu Ala Glu Ala Arg Glu Lys Glu Thr Lys Ala Leu Ser Leu 
        1475                1480                1485


Ala Arg Ala Leu Glu Glu Ala Leu Glu Ala Lys Glu Glu Leu Glu Arg 
    1490                1495                1500


Thr Asn Lys Met Leu Lys Ala Glu Met Glu Asp Leu Val Ser Ser Lys 
1505                1510                1515                1520


Asp Asp Val Gly Lys Asn Val His Glu Leu Glu Lys Ser Lys Arg Ala 
                1525                1530                1535


Leu Glu Thr Gln Met Glu Glu Met Lys Thr Gln Leu Glu Glu Leu Glu 
            1540                1545                1550


Asp Glu Leu Gln Ala Thr Glu Asp Ala Lys Leu Arg Leu Glu Val Asn 
        1555                1560                1565


Met Gln Ala Leu Lys Gly Gln Phe Glu Arg Asp Leu Gln Ala Arg Asp 
    1570                1575                1580


Glu Gln Asn Glu Glu Lys Arg Arg Gln Leu Gln Arg Gln Leu His Glu 
1585                1590                1595                1600


Tyr Glu Thr Glu Leu Glu Asp Glu Arg Lys Gln Arg Ala Leu Ala Ala 
                1605                1610                1615


Ala Ala Lys Lys Lys Leu Glu Gly Asp Leu Lys Asp Leu Glu Leu Gln 
            1620                1625                1630


Ala Asp Ser Ala Ile Lys Gly Arg Glu Glu Ala Ile Lys Gln Leu Arg 
        1635                1640                1645


Lys Leu Gln Ala Gln Met Lys Asp Phe Gln Arg Glu Leu Glu Asp Ala 
    1650                1655                1660


Arg Ala Ser Arg Asp Glu Ile Phe Ala Thr Ala Lys Glu Asn Glu Lys 
1665                1670                1675                1680


Lys Ala Lys Ser Leu Glu Ala Asp Leu Met Gln Leu Gln Glu Asp Leu 
                1685                1690                1695


Ala Ala Ala Glu Arg Ala Arg Lys Gln Ala Asp Leu Glu Lys Glu Glu 
            1700                1705                1710


Leu Ala Glu Glu Leu Ala Ser Ser Leu Ser Gly Arg Asn Ala Leu Gln 
        1715                1720                1725


Asp Glu Lys Arg Arg Leu Glu Ala Arg Ile Ala Gln Leu Glu Glu Glu 
    1730                1735                1740


Leu Glu Glu Glu Gln Gly Asn Met Glu Ala Met Ser Asp Arg Val Arg 
1745                1750                1755                1760


Lys Ala Thr Gln Gln Ala Glu Gln Leu Ser Asn Glu Leu Ala Thr Glu 
                1765                1770                1775


Arg Ser Thr Ala Gln Lys Asn Glu Ser Ala Arg Gln Gln Leu Glu Arg 
            1780                1785                1790


Gln Asn Lys Glu Leu Arg Ser Lys Leu His Glu Met Glu Gly Ala Val 
        1795                1800                1805


Lys Ser Lys Phe Lys Ser Thr Ile Ala Ala Leu Glu Ala Lys Ile Ala 
    1810                1815                1820


Gln Leu Glu Glu Gln Val Glu Gln Glu Ala Arg Glu Lys Gln Ala Ala 
1825                1830                1835                1840


Thr Lys Ser Leu Lys Gln Lys Asp Lys Lys Leu Lys Glu Ile Leu Leu 
                1845                1850                1855


Gln Val Glu Asp Glu Arg Lys Met Ala Glu Gln Tyr Lys Glu Gln Ala 
            1860                1865                1870


Glu Lys Gly Asn Ala Arg Val Lys Gln Leu Lys Arg Gln Leu Glu Glu 
        1875                1880                1885


Ala Glu Glu Glu Ser Gln Arg Ile Asn Ala Asn Arg Arg Lys Leu Gln 
    1890                1895                1900


Arg Glu Leu Asp Glu Ala Thr Glu Ser Asn Glu Ala Met Gly Arg Glu 
1905                1910                1915                1920


Val Asn Ala Leu Lys Ser Lys Leu Arg Arg Gly Asn Glu Thr Ser Phe 
                1925                1930                1935


Val Pro Ser Arg Arg Ser Gly Gly Arg Arg Val Ile Glu Asn Ala Asp 
            1940                1945                1950


Gly Ser Glu Glu Glu Thr Asp Thr Arg Asp Ala Asp Phe Asn Gly Thr 
        1955                1960                1965


Lys Ala Ser Glu 
    1970


<210>  1091
<211>  6921
<212>  DNA
<213>  Homo sapiens

<400>  1091
gggagatttg gacgctccgg cctgggaggt gcgtcagatc cgagctcgcc atccagtttc     60

ctctccacta gtccccccag ttggagatct gggaccaaca aggcaccatg gcgcagaagg    120

gccaactcag tgacgatgag aagttcctct ttgtggacaa aaacttcatc aacagcccag    180

tggcccaggc tgactgggcc gccaagagac tcgtctgggt cccctcggag aagcagggct    240

tcgaggcagc cagcattaag gaggagaagg gggatgaggt ggttgtggag ctggtggaga    300

atggcaagaa ggtcacggtt gggaaagatg acatccagaa gatgaaccca cccaagttct    360

ccaaggtgga ggacatggcg gagctgacgt gcctcaacga agcctccgtg ctacacaacc    420

tgagggagcg gtacttctca gggctaatat atacgtactc tggcctcttc tgcgtggtgg    480

tcaaccccta taaacacctg cccatctact cggagaagat cgtcgacatg tacaagggca    540

agaagaggca cgagatgccg cctcacatct acgccatcgc agacacggcc taccggagca    600

tgcttcaaga tcgggaggac cagtccattc tatgcacagg cgagtctgga gccgggaaaa    660

ccgaaaacac caagaaggtc attcagtacc tggccgtggt ggcctcctcc cacaagggca    720

agaaagacac aagtatcacg ggagagctgg aaaagcagct tctacaagca aacccgattc    780

tggaggcttt cggcaacgcc aaaacagtga agaacgacaa ctcctcacga ttcggcaaat    840

tcatccgcat caacttcgac gtcacgggtt acatcgtggg agccaacatt gagacctatc    900

tgctagaaaa atcacgggca attcgccaag ccagagacga gaggacattc cacatctttt    960

actacatgat tgctggagcc aaggagaaga tgagaagtga cttgcttttg gagggcttca   1020

acaactacac cttcctctcc aatggctttg tgcccatccc agcagcccag gatgatgaga   1080

tgttccagga aaccgtggag gccatggcaa tcatgggttt cagcgaggag gagcagctat   1140

ccatattgaa ggtggtatca tcggtcctgc agcttggaaa tatcgtcttc aagaaggaaa   1200

gaaacacaga ccaggcgtcc atgccagata acacagctgc tcagaaagtt tgccacctca   1260

tgggaattaa tgtgacagat ttcaccagat ccatcctcac tcctcgtatc aaggttgggc   1320

gagatgtggt acagaaagct cagacaaaag aacaggctga ctttgctgta gaggctttgg   1380

ccaaggcaac atatgagcgc cttttccgct ggatactcac ccgcgtgaac aaagccctgg   1440

acaagaccca tcggcaaggg gcttccttcc tggggatcct ggatatagct ggatttgaga   1500

tctttgaggt gaactccttc gagcagctgt gcatcaacta caccaacgag aagctgcagc   1560

agctcttcaa ccacaccatg ttcatcctgg agcaggagga gtaccagcgc gagggcatcg   1620

agtggaactt catcgacttt gggctggacc tacagccctg catcgagctc atcgagcgac   1680

cgaacaaccc tccaggtgtg ctggccctgc tggacgagga atgctggttc cccaaagcca   1740

cggacaagtc tttcgtggag aagctgtgca cggagcaggg cagccacccc aagttccaga   1800

agcccaagca gctcaaggac aagactgagt tctccatcat ccattatgct gggaaggtgg   1860

actataatgc gagtgcctgg ctgaccaaga atatggaccc gctgaatgac aacgtgactt   1920

ccctgctcaa tgcctcctcc gacaagtttg tggccgacct gtggaaggac gtggaccgca   1980

tcgtgggcct ggaccagatg gccaagatga cggagagctc gctgcccagc gcctccaaga   2040

ccaagaaggg catgttccgc acagtggggc agctgtacaa ggagcagctg ggcaagctga   2100

tgaccacgct acgcaacacc acgcccaact tcgtgcgctg catcatcccc aaccacgaga   2160

agaggtccgg caagctggat gcgttcctgg tgctggagca gctgcggtgc aatggggtgc   2220

tggaaggcat tcgcatctgc cggcagggct tccccaaccg gatcgtcttc caggagttcc   2280

gccaacgcta cgagatcctg gcggcgaatg ccatccccaa aggcttcatg gacgggaagc   2340

aggcctgcat tctcatgatc aaagccctgg aacttgaccc caacttatac aggatagggc   2400

agagcaaaat cttcttccga actggcgtcc tggcccacct agaggaggag cgagatttga   2460

agatcaccga tgtcatcatg gccttccagg cgatgtgtcg tggctacttg gccagaaagg   2520

cttttgccaa gaggcagcag cagctgaccg ccatgaaggt gattcagagg aactgcgccg   2580

cctacctcaa gctgcggaac tggcagtggt ggaggctttt caccaaagtg aagccactgc   2640

tgcaggtgac acggcaggag gaggagatgc aggccaagga ggatgaactg cagaagacca   2700

aggagcggca gcagaaggca gagaatgagc ttaaggagct ggaacagaag cactcgcagc   2760

tgaccgagga gaagaacctg ctacaggaac agctgcaggc agagacagag ctgtatgcag   2820

aggctgagga gatgcgggtg cggctggcgg ccaagaagca ggagctggag gagatactgc   2880

atgagatgga ggcccgcctg gaggaggagg aagacagggg ccagcagcta caggctgaaa   2940

ggaagaagat ggcccagcag atgctggacc ttgaagaaca gctggaggag gaggaagctg   3000

ccaggcagaa gctgcaactt gagaaggtca cggctgaggc caagatcaag aaactggagg   3060

atgagatcct ggtcatggat gatcagaaca ataaactatc aaaagaacga aaactccttg   3120

aggagaggat tagtgactta acgacaaatc ttgcagaaga ggaagaaaag gccaagaatc   3180

ttaccaagct gaaaaacaag catgaatcta tgatttcaga actggaagtg cggctaaaga   3240

aggaagagaa gagccgacag gagctggaga agctgaaacg gaagctggag ggtgatgcca   3300

gcgacttcca cgagcagatc gctgacctcc aggcgcagat cgcagagctc aagatgcagc   3360

tggccaagaa ggaggaggag ctgcaggcgg ccctggccag gcttgacgat gaaatcgctc   3420

agaagaacaa tgccctgaag aagatccggg agctggaggg ccacatctca gacctccagg   3480

aggacctgga ctcagagcgg gccgccagga acaaggctga aaagcagaag cgagacctcg   3540

gcgaggagct ggaggcccta aagacagagc tggaagacac actggacagc acagccactc   3600

agcaggagct cagggccaag agggagcagg aggtgacggt gctgaagaag gccctggatg   3660

aagagacgcg gtcccatgag gctcaggtcc aggagatgag gcagaaacac gcacaggcgg   3720

tggaggagct cacagagcag cttgagcagt tcaagagggc caaggcgaac ctagacaaga   3780

ataagcagac gctggagaaa gagaacgcag acctggccgg ggagctgcgg gtcctgggcc   3840

aggccaagca ggaggtggaa cataagaaga agaagctgga ggcgcaggtg caggagctgc   3900

agtccaagtg cagcgatggg gagcgggccc gggcggagct caatgacaaa gtccacaagc   3960

tgcagaatga agttgagagc gtcacaggga tgcttaacga ggccgagggg aaggccatta   4020

agctggccaa ggacgtggcg tccctcagtt cccagctcca ggacacccag gagctgcttc   4080

aagaagaaac ccggcagaag ctcaacgtgt ctacgaagct gcgccagctg gaggaggagc   4140

ggaacagcct gcaagaccag ctggacgagg agatggaggc caagcagaac ctggagcgcc   4200

acatctccac tctcaacatc cagctctccg actcgaagaa gaagctgcag gactttgcca   4260

gcaccgtgga agctctggaa gaggggaaga agaggttcca gaaggagatc gagaacctca   4320

cccagcagta cgaggagaag gcggccgctt atgataaact ggaaaagacc aagaacaggc   4380

ttcagcagga gctggacgac ctggttgttg atttggacaa ccagcggcaa ctcgtgtcca   4440

acctggaaaa gaagcagagg aaatttgatc agttgttagc cgaggagaaa aacatctctt   4500

ccaaatacgc ggatgagagg gacagagctg aggcagaagc cagggagaag gaaaccaagg   4560

ccctgtccct ggctcgggcc cttgaagagg ccttggaagc caaagaggaa ctcgagcgga   4620

ccaacaaaat gctcaaagcc gaaatggaag acctggtcag ctccaaggat gacgtgggca   4680

agaacgtcca tgagctggag aagtccaagc gggccctgga gacccagatg gaggagatga   4740

agacgcagct ggaagagctg gaggacgagc tgcaagccac ggaggacgcc aaactgcggc   4800

tggaagtcaa catgcaggcg ctcaagggcc agttcgaaag ggatctccaa gcccgggacg   4860

agcagaatga ggagaagagg aggcaactgc agagacagct tcacgagtat gagacggaac   4920

tggaagacga gcgaaagcaa cgtgccctgg cagctgcagc aaagaagaag ctggaagggg   4980

acctgaaaga cctggagctt caggccgact ctgccatcaa ggggagggag gaagccatca   5040

agcagctacg caaactgcag gctcagatga aggactttca aagagagctg gaagatgccc   5100

gtgcctccag agatgagatc tttgccacag ccaaagagaa tgagaagaaa gccaagagct   5160

tggaagcaga cctcatgcag ctacaagagg acctcgccgc cgctgagagg gctcgcaaac   5220

aagcggacct cgagaaggag gaactggcag aggagctggc cagtagcctg tcgggaagga   5280

acgcactcca ggacgagaag cgccgcctgg aggcccggat cgcccagctg gaggaggagc   5340

tggaggagga gcagggcaac atggaggcca tgagcgaccg ggtccgcaaa gccacacagc   5400

aggccgagca gctcagcaac gagctggcca cagagcgcag cacggcccag aagaatgaga   5460

gtgcccggca gcagctcgag cggcagaaca aggagctccg gagcaagctc cacgagatgg   5520

agggggccgt caagtccaag ttcaagtcca ccatcgcggc gctggaggcc aagattgcac   5580

agctggagga gcaggtcgag caggaggcca gagagaaaca ggcggccacc aagtcgctga   5640

agcagaaaga caagaagctg aaggaaatct tgctgcaggt ggaggacgag cgcaagatgg   5700

ccgagcagta caaggagcag gcagagaaag gcaatgccag ggtcaagcag ctcaagaggc   5760

agctggagga ggcagaggag gagtcccagc gcatcaacgc caaccgcagg aagctgcagc   5820

gggagctgga tgaggccacg gagagcaacg aggccatggg ccgcgaggtg aacgcactca   5880

agagcaagct cagagggccc cccccacagg aaacttcgca gtgatgcacc aggcgaggaa   5940

acgagacctc tttcgttcct tctagaaggt ctggaggacg tagagttatt gaaaatgcag   6000

atggttctga ggaggaaacg gacactcgag acgcagactt caatggaacc aaggccagtg   6060

aataagcaac tttctacagt tttgcaccac ggcaagaaaa ccaaaaacca aaacaaacaa   6120

acaaaaaaaa cccaacaaca acccagaaca aagcaaaacc cagcagactg tacttagcat   6180

tgtctaaatc cattctcaaa ttccaaatat cacagacacc cctcacacaa ggaatataaa   6240

aaccaccacc ctccagcctg ggcaacgtag taaaacctca tctatacaag aatttaaaaa   6300

taagctgggc gtggtggtac acacctgtgg tcccagctac tagggaggct gagccaggaa   6360

gaacgctcca gcccaggact tcgaggctgc aatgagctat aattgcatca ttgcactcca   6420

gcctgggcaa cagagaccct gtctcaacca ccaccaccac caccacccct actacccctg   6480

tattcaaggt aaaaattgaa gtttgtatga tgtaagagat gagaaaaacc caacaggaaa   6540

cacagacaca tcctccagtt ctatcaatgg attgtgcaga cactgagttt ttagaaaaac   6600

atatccacgg taaccggtcc ctggcaattc tgtttacatg aaatggggag aaagtcaccg   6660

aaatgggtgc cgccggcccc cactcccaat tcattcccta acctgcaaac ctttccaact   6720

tctcacgtca ggcctttgag aattctttcc ccctctcctg gtttccacac ctcagacacg   6780

cacagttcac caagtgcctt ctgtagtcac atgaattgaa aaggagacgc tgctcccacg   6840

gaggggagca ggaatgctgc actgtttaca ccctgactgt gcttaaaaac actttcacta   6900

ataaatggtt ataaatcaca a                                             6921


<210>  1092
<211>  1938
<212>  PRT
<213>  Homo sapiens

<400>  1092

Met Ala Gln Lys Gly Gln Leu Ser Asp Asp Glu Lys Phe Leu Phe Val 
1               5                   10                  15


Asp Lys Asn Phe Ile Asn Ser Pro Val Ala Gln Ala Asp Trp Ala Ala 
            20                  25                  30


Lys Arg Leu Val Trp Val Pro Ser Glu Lys Gln Gly Phe Glu Ala Ala 
        35                  40                  45


Ser Ile Lys Glu Glu Lys Gly Asp Glu Val Val Val Glu Leu Val Glu 
    50                  55                  60


Asn Gly Lys Lys Val Thr Val Gly Lys Asp Asp Ile Gln Lys Met Asn 
65                  70                  75                  80


Pro Pro Lys Phe Ser Lys Val Glu Asp Met Ala Glu Leu Thr Cys Leu 
                85                  90                  95


Asn Glu Ala Ser Val Leu His Asn Leu Arg Glu Arg Tyr Phe Ser Gly 
            100                 105                 110


Leu Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Val Val Asn Pro Tyr 
        115                 120                 125


Lys His Leu Pro Ile Tyr Ser Glu Lys Ile Val Asp Met Tyr Lys Gly 
    130                 135                 140


Lys Lys Arg His Glu Met Pro Pro His Ile Tyr Ala Ile Ala Asp Thr 
145                 150                 155                 160


Ala Tyr Arg Ser Met Leu Gln Asp Arg Glu Asp Gln Ser Ile Leu Cys 
                165                 170                 175


Thr Gly Glu Ser Gly Ala Gly Lys Thr Glu Asn Thr Lys Lys Val Ile 
            180                 185                 190


Gln Tyr Leu Ala Val Val Ala Ser Ser His Lys Gly Lys Lys Asp Thr 
        195                 200                 205


Ser Ile Thr Gly Glu Leu Glu Lys Gln Leu Leu Gln Ala Asn Pro Ile 
    210                 215                 220


Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Lys Asn Asp Asn Ser Ser 
225                 230                 235                 240


Arg Phe Gly Lys Phe Ile Arg Ile Asn Phe Asp Val Thr Gly Tyr Ile 
                245                 250                 255


Val Gly Ala Asn Ile Glu Thr Tyr Leu Leu Glu Lys Ser Arg Ala Ile 
            260                 265                 270


Arg Gln Ala Arg Asp Glu Arg Thr Phe His Ile Phe Tyr Tyr Met Ile 
        275                 280                 285


Ala Gly Ala Lys Glu Lys Met Arg Ser Asp Leu Leu Leu Glu Gly Phe 
    290                 295                 300


Asn Asn Tyr Thr Phe Leu Ser Asn Gly Phe Val Pro Ile Pro Ala Ala 
305                 310                 315                 320


Gln Asp Asp Glu Met Phe Gln Glu Thr Val Glu Ala Met Ala Ile Met 
                325                 330                 335


Gly Phe Ser Glu Glu Glu Gln Leu Ser Ile Leu Lys Val Val Ser Ser 
            340                 345                 350


Val Leu Gln Leu Gly Asn Ile Val Phe Lys Lys Glu Arg Asn Thr Asp 
        355                 360                 365


Gln Ala Ser Met Pro Asp Asn Thr Ala Ala Gln Lys Val Cys His Leu 
    370                 375                 380


Met Gly Ile Asn Val Thr Asp Phe Thr Arg Ser Ile Leu Thr Pro Arg 
385                 390                 395                 400


Ile Lys Val Gly Arg Asp Val Val Gln Lys Ala Gln Thr Lys Glu Gln 
                405                 410                 415


Ala Asp Phe Ala Val Glu Ala Leu Ala Lys Ala Thr Tyr Glu Arg Leu 
            420                 425                 430


Phe Arg Trp Ile Leu Thr Arg Val Asn Lys Ala Leu Asp Lys Thr His 
        435                 440                 445


Arg Gln Gly Ala Ser Phe Leu Gly Ile Leu Asp Ile Ala Gly Phe Glu 
    450                 455                 460


Ile Phe Glu Val Asn Ser Phe Glu Gln Leu Cys Ile Asn Tyr Thr Asn 
465                 470                 475                 480


Glu Lys Leu Gln Gln Leu Phe Asn His Thr Met Phe Ile Leu Glu Gln 
                485                 490                 495


Glu Glu Tyr Gln Arg Glu Gly Ile Glu Trp Asn Phe Ile Asp Phe Gly 
            500                 505                 510


Leu Asp Leu Gln Pro Cys Ile Glu Leu Ile Glu Arg Pro Asn Asn Pro 
        515                 520                 525


Pro Gly Val Leu Ala Leu Leu Asp Glu Glu Cys Trp Phe Pro Lys Ala 
    530                 535                 540


Thr Asp Lys Ser Phe Val Glu Lys Leu Cys Thr Glu Gln Gly Ser His 
545                 550                 555                 560


Pro Lys Phe Gln Lys Pro Lys Gln Leu Lys Asp Lys Thr Glu Phe Ser 
                565                 570                 575


Ile Ile His Tyr Ala Gly Lys Val Asp Tyr Asn Ala Ser Ala Trp Leu 
            580                 585                 590


Thr Lys Asn Met Asp Pro Leu Asn Asp Asn Val Thr Ser Leu Leu Asn 
        595                 600                 605


Ala Ser Ser Asp Lys Phe Val Ala Asp Leu Trp Lys Asp Val Asp Arg 
    610                 615                 620


Ile Val Gly Leu Asp Gln Met Ala Lys Met Thr Glu Ser Ser Leu Pro 
625                 630                 635                 640


Ser Ala Ser Lys Thr Lys Lys Gly Met Phe Arg Thr Val Gly Gln Leu 
                645                 650                 655


Tyr Lys Glu Gln Leu Gly Lys Leu Met Thr Thr Leu Arg Asn Thr Thr 
            660                 665                 670


Pro Asn Phe Val Arg Cys Ile Ile Pro Asn His Glu Lys Arg Ser Gly 
        675                 680                 685


Lys Leu Asp Ala Phe Leu Val Leu Glu Gln Leu Arg Cys Asn Gly Val 
    690                 695                 700


Leu Glu Gly Ile Arg Ile Cys Arg Gln Gly Phe Pro Asn Arg Ile Val 
705                 710                 715                 720


Phe Gln Glu Phe Arg Gln Arg Tyr Glu Ile Leu Ala Ala Asn Ala Ile 
                725                 730                 735


Pro Lys Gly Phe Met Asp Gly Lys Gln Ala Cys Ile Leu Met Ile Lys 
            740                 745                 750


Ala Leu Glu Leu Asp Pro Asn Leu Tyr Arg Ile Gly Gln Ser Lys Ile 
        755                 760                 765


Phe Phe Arg Thr Gly Val Leu Ala His Leu Glu Glu Glu Arg Asp Leu 
    770                 775                 780


Lys Ile Thr Asp Val Ile Met Ala Phe Gln Ala Met Cys Arg Gly Tyr 
785                 790                 795                 800


Leu Ala Arg Lys Ala Phe Ala Lys Arg Gln Gln Gln Leu Thr Ala Met 
                805                 810                 815


Lys Val Ile Gln Arg Asn Cys Ala Ala Tyr Leu Lys Leu Arg Asn Trp 
            820                 825                 830


Gln Trp Trp Arg Leu Phe Thr Lys Val Lys Pro Leu Leu Gln Val Thr 
        835                 840                 845


Arg Gln Glu Glu Glu Met Gln Ala Lys Glu Asp Glu Leu Gln Lys Thr 
    850                 855                 860


Lys Glu Arg Gln Gln Lys Ala Glu Asn Glu Leu Lys Glu Leu Glu Gln 
865                 870                 875                 880


Lys His Ser Gln Leu Thr Glu Glu Lys Asn Leu Leu Gln Glu Gln Leu 
                885                 890                 895


Gln Ala Glu Thr Glu Leu Tyr Ala Glu Ala Glu Glu Met Arg Val Arg 
            900                 905                 910


Leu Ala Ala Lys Lys Gln Glu Leu Glu Glu Ile Leu His Glu Met Glu 
        915                 920                 925


Ala Arg Leu Glu Glu Glu Glu Asp Arg Gly Gln Gln Leu Gln Ala Glu 
    930                 935                 940


Arg Lys Lys Met Ala Gln Gln Met Leu Asp Leu Glu Glu Gln Leu Glu 
945                 950                 955                 960


Glu Glu Glu Ala Ala Arg Gln Lys Leu Gln Leu Glu Lys Val Thr Ala 
                965                 970                 975


Glu Ala Lys Ile Lys Lys Leu Glu Asp Glu Ile Leu Val Met Asp Asp 
            980                 985                 990


Gln Asn Asn Lys Leu Ser Lys Glu Arg Lys Leu Leu Glu Glu Arg Ile 
        995                 1000                1005


Ser Asp Leu Thr Thr Asn Leu Ala Glu Glu Glu Glu Lys Ala Lys Asn 
    1010                1015                1020


Leu Thr Lys Leu Lys Asn Lys His Glu Ser Met Ile Ser Glu Leu Glu 
1025                1030                1035                1040


Val Arg Leu Lys Lys Glu Glu Lys Ser Arg Gln Glu Leu Glu Lys Leu 
                1045                1050                1055


Lys Arg Lys Leu Glu Gly Asp Ala Ser Asp Phe His Glu Gln Ile Ala 
            1060                1065                1070


Asp Leu Gln Ala Gln Ile Ala Glu Leu Lys Met Gln Leu Ala Lys Lys 
        1075                1080                1085


Glu Glu Glu Leu Gln Ala Ala Leu Ala Arg Leu Asp Asp Glu Ile Ala 
    1090                1095                1100


Gln Lys Asn Asn Ala Leu Lys Lys Ile Arg Glu Leu Glu Gly His Ile 
1105                1110                1115                1120


Ser Asp Leu Gln Glu Asp Leu Asp Ser Glu Arg Ala Ala Arg Asn Lys 
                1125                1130                1135


Ala Glu Lys Gln Lys Arg Asp Leu Gly Glu Glu Leu Glu Ala Leu Lys 
            1140                1145                1150


Thr Glu Leu Glu Asp Thr Leu Asp Ser Thr Ala Thr Gln Gln Glu Leu 
        1155                1160                1165


Arg Ala Lys Arg Glu Gln Glu Val Thr Val Leu Lys Lys Ala Leu Asp 
    1170                1175                1180


Glu Glu Thr Arg Ser His Glu Ala Gln Val Gln Glu Met Arg Gln Lys 
1185                1190                1195                1200


His Ala Gln Ala Val Glu Glu Leu Thr Glu Gln Leu Glu Gln Phe Lys 
                1205                1210                1215


Arg Ala Lys Ala Asn Leu Asp Lys Asn Lys Gln Thr Leu Glu Lys Glu 
            1220                1225                1230


Asn Ala Asp Leu Ala Gly Glu Leu Arg Val Leu Gly Gln Ala Lys Gln 
        1235                1240                1245


Glu Val Glu His Lys Lys Lys Lys Leu Glu Ala Gln Val Gln Glu Leu 
    1250                1255                1260


Gln Ser Lys Cys Ser Asp Gly Glu Arg Ala Arg Ala Glu Leu Asn Asp 
1265                1270                1275                1280


Lys Val His Lys Leu Gln Asn Glu Val Glu Ser Val Thr Gly Met Leu 
                1285                1290                1295


Asn Glu Ala Glu Gly Lys Ala Ile Lys Leu Ala Lys Asp Val Ala Ser 
            1300                1305                1310


Leu Ser Ser Gln Leu Gln Asp Thr Gln Glu Leu Leu Gln Glu Glu Thr 
        1315                1320                1325


Arg Gln Lys Leu Asn Val Ser Thr Lys Leu Arg Gln Leu Glu Glu Glu 
    1330                1335                1340


Arg Asn Ser Leu Gln Asp Gln Leu Asp Glu Glu Met Glu Ala Lys Gln 
1345                1350                1355                1360


Asn Leu Glu Arg His Ile Ser Thr Leu Asn Ile Gln Leu Ser Asp Ser 
                1365                1370                1375


Lys Lys Lys Leu Gln Asp Phe Ala Ser Thr Val Glu Ala Leu Glu Glu 
            1380                1385                1390


Gly Lys Lys Arg Phe Gln Lys Glu Ile Glu Asn Leu Thr Gln Gln Tyr 
        1395                1400                1405


Glu Glu Lys Ala Ala Ala Tyr Asp Lys Leu Glu Lys Thr Lys Asn Arg 
    1410                1415                1420


Leu Gln Gln Glu Leu Asp Asp Leu Val Val Asp Leu Asp Asn Gln Arg 
1425                1430                1435                1440


Gln Leu Val Ser Asn Leu Glu Lys Lys Gln Arg Lys Phe Asp Gln Leu 
                1445                1450                1455


Leu Ala Glu Glu Lys Asn Ile Ser Ser Lys Tyr Ala Asp Glu Arg Asp 
            1460                1465                1470


Arg Ala Glu Ala Glu Ala Arg Glu Lys Glu Thr Lys Ala Leu Ser Leu 
        1475                1480                1485


Ala Arg Ala Leu Glu Glu Ala Leu Glu Ala Lys Glu Glu Leu Glu Arg 
    1490                1495                1500


Thr Asn Lys Met Leu Lys Ala Glu Met Glu Asp Leu Val Ser Ser Lys 
1505                1510                1515                1520


Asp Asp Val Gly Lys Asn Val His Glu Leu Glu Lys Ser Lys Arg Ala 
                1525                1530                1535


Leu Glu Thr Gln Met Glu Glu Met Lys Thr Gln Leu Glu Glu Leu Glu 
            1540                1545                1550


Asp Glu Leu Gln Ala Thr Glu Asp Ala Lys Leu Arg Leu Glu Val Asn 
        1555                1560                1565


Met Gln Ala Leu Lys Gly Gln Phe Glu Arg Asp Leu Gln Ala Arg Asp 
    1570                1575                1580


Glu Gln Asn Glu Glu Lys Arg Arg Gln Leu Gln Arg Gln Leu His Glu 
1585                1590                1595                1600


Tyr Glu Thr Glu Leu Glu Asp Glu Arg Lys Gln Arg Ala Leu Ala Ala 
                1605                1610                1615


Ala Ala Lys Lys Lys Leu Glu Gly Asp Leu Lys Asp Leu Glu Leu Gln 
            1620                1625                1630


Ala Asp Ser Ala Ile Lys Gly Arg Glu Glu Ala Ile Lys Gln Leu Arg 
        1635                1640                1645


Lys Leu Gln Ala Gln Met Lys Asp Phe Gln Arg Glu Leu Glu Asp Ala 
    1650                1655                1660


Arg Ala Ser Arg Asp Glu Ile Phe Ala Thr Ala Lys Glu Asn Glu Lys 
1665                1670                1675                1680


Lys Ala Lys Ser Leu Glu Ala Asp Leu Met Gln Leu Gln Glu Asp Leu 
                1685                1690                1695


Ala Ala Ala Glu Arg Ala Arg Lys Gln Ala Asp Leu Glu Lys Glu Glu 
            1700                1705                1710


Leu Ala Glu Glu Leu Ala Ser Ser Leu Ser Gly Arg Asn Ala Leu Gln 
        1715                1720                1725


Asp Glu Lys Arg Arg Leu Glu Ala Arg Ile Ala Gln Leu Glu Glu Glu 
    1730                1735                1740


Leu Glu Glu Glu Gln Gly Asn Met Glu Ala Met Ser Asp Arg Val Arg 
1745                1750                1755                1760


Lys Ala Thr Gln Gln Ala Glu Gln Leu Ser Asn Glu Leu Ala Thr Glu 
                1765                1770                1775


Arg Ser Thr Ala Gln Lys Asn Glu Ser Ala Arg Gln Gln Leu Glu Arg 
            1780                1785                1790


Gln Asn Lys Glu Leu Arg Ser Lys Leu His Glu Met Glu Gly Ala Val 
        1795                1800                1805


Lys Ser Lys Phe Lys Ser Thr Ile Ala Ala Leu Glu Ala Lys Ile Ala 
    1810                1815                1820


Gln Leu Glu Glu Gln Val Glu Gln Glu Ala Arg Glu Lys Gln Ala Ala 
1825                1830                1835                1840


Thr Lys Ser Leu Lys Gln Lys Asp Lys Lys Leu Lys Glu Ile Leu Leu 
                1845                1850                1855


Gln Val Glu Asp Glu Arg Lys Met Ala Glu Gln Tyr Lys Glu Gln Ala 
            1860                1865                1870


Glu Lys Gly Asn Ala Arg Val Lys Gln Leu Lys Arg Gln Leu Glu Glu 
        1875                1880                1885


Ala Glu Glu Glu Ser Gln Arg Ile Asn Ala Asn Arg Arg Lys Leu Gln 
    1890                1895                1900


Arg Glu Leu Asp Glu Ala Thr Glu Ser Asn Glu Ala Met Gly Arg Glu 
1905                1910                1915                1920


Val Asn Ala Leu Lys Ser Lys Leu Arg Gly Pro Pro Pro Gln Glu Thr 
                1925                1930                1935


Ser Gln 



<210>  1093
<211>  4867
<212>  DNA
<213>  Homo sapiens

<400>  1093
gcggagctcg agcgctgttg tgtgtttgga aggaaggatg ctgctgccaa tttgtgggac     60

cgctgctgcg aggagtgggc gtggcctcgg cggtgtggat gcttgttagg aaagatgctg    120

agtgcttttc agtgaggagt cagggaggtg tgtgtgagag agagagagaa aagagagaga    180

cagagacggg gagagagaga gggagagaga agagagggag gagggaagaa gaaaagacgg    240

agggaggtga ggaggaaggg agggggagag acagagacct agaggggctg aagacccaga    300

cagagctggc agagctactg agaagaggac tggagcgctc tgagagcctc tcaagatctt    360

ttgggggagc ccaataaatg tgaacatggg atctgtcacg ggagctgtcc tcaagacgct    420

acttctgtta tctactcaaa attggaacag agtcgaagct gggaattcct atgactgtga    480

tgatcctctt gtgtctgcct tgcctcaggc atccttcagc agttcttccg agctctccag    540

cagtcatggt cctggatttg caaggctgaa tagaagagat ggagctggtg gctggtctcc    600

acttgtgtct aacaaatacc agtggttgca gattgacctt ggagagagaa tggaggtcac    660

cgctgtggcc actcaagggg gatatggtag ctccaactgg gtgaccagct acctcctgat    720

gttcagtgat agtggctgga actggaaaca atatcgccaa gaggacagca tctggggttt    780

ttcaggaaat gcaaatgcag acagtgttgt gtactataga ctccagcctt ctatcaaagc    840

cagatttctg cgcttcatcc ctttggaatg gaaccccaag ggcagaattg gaatgcgaat    900

cgaagtgttc ggatgtgcat acagatcaga agtggttgat cttgatggaa aaagttccct    960

tctctacaga tttgatcaaa aatccctgag cccaataaaa gacattattt ctttgaaatt   1020

caaaaccatg cagagtgatg ggattctact ccacagggaa gggccaaatg gagatcacat   1080

cacactgcaa ttaagaagag caagactctt tttacttatt aattcaggtg aagctaaact   1140

gccttccact tccaccctgg tcaatctcac cctgggcagc ctgctagatg atcagcattg   1200

gcattcagtg ctcatccagc gtttgggcaa acaagtcaac ttcacagtgg acgaacacag   1260

gcatcatttc catgcacggg gagaattcaa tctcatgaat cttgattatg agatcagctt   1320

tggagggatt ccagcacctg gaaaatcagt gtcattccca catagaaatt ttcatggatg   1380

tttagaaaat ctctattata atggagtgga tatcattgat ttggccaagc agcaaaaacc   1440

acagatcatt gctatgggaa atgtgtcatt ttcttgttca caaccacaat ctatgcccgt   1500

gacttttctg agctccagga gttatttagc actgccagac ttctctggag aggaggaggt   1560

ttctgccact tttcaatttc gaacttggaa taaggcaggg cttctgctgt tcagtgaact   1620

tcagctgatt tcagggggta tcctcctctt tctgagtgat ggaaaactta agtcgaatct   1680

ctaccagcca ggaaaattac ccagtgacat cacagcaggt gtcgaattaa atgatgggca   1740

gtggcattct gtctctttat ctgctaaaaa gaatcacttg agtgtggcgg tggacggcca   1800

gatggcttct gctgctcctc tgctggggcc tgagcagatt tattcgggtg gcacctatta   1860

ttttggaggt tgtcctgaca aaagctttgg atccaaatgt aaaagtccac ttggtggatt   1920

tcagggatgt atgaggctca tttctatcag cggcaaagtg gtagatctga tttcagttca   1980

gcaggggtcc cttgggaact tcagtgacct tcagatagac tcatgtggca tctcagacag   2040

gtgtttgccc aactattgtg aacacggtgg ggagtgttcc cagtcctgga gcacctttca   2100

ttgtaactgt accaacactg gttacagagg agctacttgc cataactcta tctatgagca   2160

gtcatgtgaa gcctataagc acagaggaaa tacttcaggg ttttactata tagattcaga   2220

tggaagtggt cccctggaac catttcttct atattgcaat atgaccgaaa ctgcatggac   2280

catcatacag cacaacggct ctgacttaac aagagtcaga aatactaatc cagagaaccc   2340

atatgctggg tttttcgagt atgtggccag catggagcaa cttcaggcca ctattaaccg   2400

tgcagagcac tgtgaacagg agtttactta ttactgcaag aagtcacggc tggtcaataa   2460

gcaagatgga acccctctga gttggtgggt aggaagaacc aatgaaacgc aaacctactg   2520

gggaggttct tcgcctgatc ttcaaaaatg tacttgtgga ttagagggaa actgcattga   2580

ttctcagtat tactgcaatt gtgatgctga ccggaatgaa tggaccaatg acactggatt   2640

gcttgcttat aaagaacatc ttccagtaac taagatcgtg attacagaca caggccgact   2700

gcattcagaa gcagcttata aactggggcc tctgctctgc cagggagaca gatcattttg   2760

gaattcagct tcctttgata ccgaggcttc atatcttcat tttcctacct tccacggaga   2820

acttagcgcg gatgtatctt tcttttttaa gacaacagct tcatctgggg tatttttaga   2880

gaacttgggg attgctgatt ttatacggat agagcttcgc tctccgacag tagtgacttt   2940

ttcatttgat gtggggaatg ggccttttga aatctcagtg cagtcaccca cccacttcaa   3000

cgacaaccag tggcaccatg tgagggttga aaggaacatg aaggaggcct cccttcaagt   3060

ggatcagctg acaccaaaga cacagcccgc ccccgctgat gggcatgtcc tgttacagct   3120

caacagtcag ctcttcgtgg gtggaacggc caccagacag agaggctttc tgggctgcat   3180

tcggtctctg cagttgaatg ggatgaccct ggatttggaa gaaagagccc aggtgactcc   3240

agaagtgcag ccaggttgta ggggacattg cagcagctat gggaagttat gccgcaatgg   3300

agggaaatgc agagaaagac ccattgggtt cttttgtgac tgcactttct ctgcatacac   3360

agggccattc tgctcaaatg agatttctgc atattttgga tctggctcat ccgtgatata   3420

caattttcaa gaaaattatc ttttaagtaa aaactccagc tcccacgctg cttcatttca   3480

tggtgatatg aagctgagca gagaaatgat caaatttagt ttccgaacaa cacgaacacc   3540

aagcttgctg ctttttgtga gctcctttta caaagaatac ctttctgtga tcattgccaa   3600

aaatggaagt ttgcagatca ggtacaagtt aaataaatat caagagcctg atgttgttaa   3660

ctttgatttt aaaaacatgg ctgatggaca acttcaccac ataatgatta acagagaaga   3720

aggagtggtc tttatagaga ttgacgataa tagaaggaga caagttcacc tgtcatcagg   3780

cacagaattc agtgcagtca aatctctggt attgggcagg attttagaac acagtgatgt   3840

ggaccaggat actgcactgg caggtgcgca gggcttcaca ggctgcctct ctgcagtgca   3900

gctcagccac gtggcccctc tgaaggcagc tctgcacccc agccacccag accctgtcac   3960

tgttacagga cacgtgactg agtccagctg tatggcccag cctggcactg atgccacatc   4020

aagggaaagg acacactcgt ttgcagatca ttctggaaca atagatgaca gagagcccct   4080

tgctaatgca atcaaaagtg actctgcagt aattggaggt ctgatagctg ttgtgatttt   4140

tatcttgctt tgcatcactg ccatagctgt tcgcatttat cagcagaaaa ggttatataa   4200

aagaagtgag gcaaaaaggt cagagaatgt agacagtgct gaggctgttc tgaaaagtga   4260

gcttaatata caaaatgcag tcaatgaaaa tcagaaagag tacttcttct gattggcagc   4320

tatgatttaa cataaaatta tgatagtttg ttttaatagc caggggttct caatggaaaa   4380

acgaatgctc ttacactgaa tgtacaggca gtgggcttgc agcactgcca tcttgccatg   4440

tacaggcttg gggtggctcc aggaagcctc gtccagtgat atatttctca tagcattcat   4500

tctatggaac aagaaattag atattgctgt taattttcaa ctgttctggt atgatctaaa   4560

acaagtttaa cctgcttaat ggctacagtt tttacatgtg aaaactgtag ccttggtctc   4620

ttaaccatgt aatacataag ttttgttaga ggtaaaaatt aaatttggac tataatgtcc   4680

ttgctttatt tgagaacatt tgctgtgttt gcttttgtct cctcgtggtg ttattcatag   4740

acctggaaat gcttctcaga tcctgtgtgg ccggtgtttg catcttcagt ggccacaagc   4800

ataataaagc ccctttgcct ttctctgtat tatattcaat acaatacatc aatagtcttg   4860

aaaaatg                                                             4867


<210>  1094
<211>  1308
<212>  PRT
<213>  Homo sapiens

<400>  1094

Met Gly Ser Val Thr Gly Ala Val Leu Lys Thr Leu Leu Leu Leu Ser 
1               5                   10                  15


Thr Gln Asn Trp Asn Arg Val Glu Ala Gly Asn Ser Tyr Asp Cys Asp 
            20                  25                  30


Asp Pro Leu Val Ser Ala Leu Pro Gln Ala Ser Phe Ser Ser Ser Ser 
        35                  40                  45


Glu Leu Ser Ser Ser His Gly Pro Gly Phe Ala Arg Leu Asn Arg Arg 
    50                  55                  60


Asp Gly Ala Gly Gly Trp Ser Pro Leu Val Ser Asn Lys Tyr Gln Trp 
65                  70                  75                  80


Leu Gln Ile Asp Leu Gly Glu Arg Met Glu Val Thr Ala Val Ala Thr 
                85                  90                  95


Gln Gly Gly Tyr Gly Ser Ser Asn Trp Val Thr Ser Tyr Leu Leu Met 
            100                 105                 110


Phe Ser Asp Ser Gly Trp Asn Trp Lys Gln Tyr Arg Gln Glu Asp Ser 
        115                 120                 125


Ile Trp Gly Phe Ser Gly Asn Ala Asn Ala Asp Ser Val Val Tyr Tyr 
    130                 135                 140


Arg Leu Gln Pro Ser Ile Lys Ala Arg Phe Leu Arg Phe Ile Pro Leu 
145                 150                 155                 160


Glu Trp Asn Pro Lys Gly Arg Ile Gly Met Arg Ile Glu Val Phe Gly 
                165                 170                 175


Cys Ala Tyr Arg Ser Glu Val Val Asp Leu Asp Gly Lys Ser Ser Leu 
            180                 185                 190


Leu Tyr Arg Phe Asp Gln Lys Ser Leu Ser Pro Ile Lys Asp Ile Ile 
        195                 200                 205


Ser Leu Lys Phe Lys Thr Met Gln Ser Asp Gly Ile Leu Leu His Arg 
    210                 215                 220


Glu Gly Pro Asn Gly Asp His Ile Thr Leu Gln Leu Arg Arg Ala Arg 
225                 230                 235                 240


Leu Phe Leu Leu Ile Asn Ser Gly Glu Ala Lys Leu Pro Ser Thr Ser 
                245                 250                 255


Thr Leu Val Asn Leu Thr Leu Gly Ser Leu Leu Asp Asp Gln His Trp 
            260                 265                 270


His Ser Val Leu Ile Gln Arg Leu Gly Lys Gln Val Asn Phe Thr Val 
        275                 280                 285


Asp Glu His Arg His His Phe His Ala Arg Gly Glu Phe Asn Leu Met 
    290                 295                 300


Asn Leu Asp Tyr Glu Ile Ser Phe Gly Gly Ile Pro Ala Pro Gly Lys 
305                 310                 315                 320


Ser Val Ser Phe Pro His Arg Asn Phe His Gly Cys Leu Glu Asn Leu 
                325                 330                 335


Tyr Tyr Asn Gly Val Asp Ile Ile Asp Leu Ala Lys Gln Gln Lys Pro 
            340                 345                 350


Gln Ile Ile Ala Met Gly Asn Val Ser Phe Ser Cys Ser Gln Pro Gln 
        355                 360                 365


Ser Met Pro Val Thr Phe Leu Ser Ser Arg Ser Tyr Leu Ala Leu Pro 
    370                 375                 380


Asp Phe Ser Gly Glu Glu Glu Val Ser Ala Thr Phe Gln Phe Arg Thr 
385                 390                 395                 400


Trp Asn Lys Ala Gly Leu Leu Leu Phe Ser Glu Leu Gln Leu Ile Ser 
                405                 410                 415


Gly Gly Ile Leu Leu Phe Leu Ser Asp Gly Lys Leu Lys Ser Asn Leu 
            420                 425                 430


Tyr Gln Pro Gly Lys Leu Pro Ser Asp Ile Thr Ala Gly Val Glu Leu 
        435                 440                 445


Asn Asp Gly Gln Trp His Ser Val Ser Leu Ser Ala Lys Lys Asn His 
    450                 455                 460


Leu Ser Val Ala Val Asp Gly Gln Met Ala Ser Ala Ala Pro Leu Leu 
465                 470                 475                 480


Gly Pro Glu Gln Ile Tyr Ser Gly Gly Thr Tyr Tyr Phe Gly Gly Cys 
                485                 490                 495


Pro Asp Lys Ser Phe Gly Ser Lys Cys Lys Ser Pro Leu Gly Gly Phe 
            500                 505                 510


Gln Gly Cys Met Arg Leu Ile Ser Ile Ser Gly Lys Val Val Asp Leu 
        515                 520                 525


Ile Ser Val Gln Gln Gly Ser Leu Gly Asn Phe Ser Asp Leu Gln Ile 
    530                 535                 540


Asp Ser Cys Gly Ile Ser Asp Arg Cys Leu Pro Asn Tyr Cys Glu His 
545                 550                 555                 560


Gly Gly Glu Cys Ser Gln Ser Trp Ser Thr Phe His Cys Asn Cys Thr 
                565                 570                 575


Asn Thr Gly Tyr Arg Gly Ala Thr Cys His Asn Ser Ile Tyr Glu Gln 
            580                 585                 590


Ser Cys Glu Ala Tyr Lys His Arg Gly Asn Thr Ser Gly Phe Tyr Tyr 
        595                 600                 605


Ile Asp Ser Asp Gly Ser Gly Pro Leu Glu Pro Phe Leu Leu Tyr Cys 
    610                 615                 620


Asn Met Thr Glu Thr Ala Trp Thr Ile Ile Gln His Asn Gly Ser Asp 
625                 630                 635                 640


Leu Thr Arg Val Arg Asn Thr Asn Pro Glu Asn Pro Tyr Ala Gly Phe 
                645                 650                 655


Phe Glu Tyr Val Ala Ser Met Glu Gln Leu Gln Ala Thr Ile Asn Arg 
            660                 665                 670


Ala Glu His Cys Glu Gln Glu Phe Thr Tyr Tyr Cys Lys Lys Ser Arg 
        675                 680                 685


Leu Val Asn Lys Gln Asp Gly Thr Pro Leu Ser Trp Trp Val Gly Arg 
    690                 695                 700


Thr Asn Glu Thr Gln Thr Tyr Trp Gly Gly Ser Ser Pro Asp Leu Gln 
705                 710                 715                 720


Lys Cys Thr Cys Gly Leu Glu Gly Asn Cys Ile Asp Ser Gln Tyr Tyr 
                725                 730                 735


Cys Asn Cys Asp Ala Asp Arg Asn Glu Trp Thr Asn Asp Thr Gly Leu 
            740                 745                 750


Leu Ala Tyr Lys Glu His Leu Pro Val Thr Lys Ile Val Ile Thr Asp 
        755                 760                 765


Thr Gly Arg Leu His Ser Glu Ala Ala Tyr Lys Leu Gly Pro Leu Leu 
    770                 775                 780


Cys Gln Gly Asp Arg Ser Phe Trp Asn Ser Ala Ser Phe Asp Thr Glu 
785                 790                 795                 800


Ala Ser Tyr Leu His Phe Pro Thr Phe His Gly Glu Leu Ser Ala Asp 
                805                 810                 815


Val Ser Phe Phe Phe Lys Thr Thr Ala Ser Ser Gly Val Phe Leu Glu 
            820                 825                 830


Asn Leu Gly Ile Ala Asp Phe Ile Arg Ile Glu Leu Arg Ser Pro Thr 
        835                 840                 845


Val Val Thr Phe Ser Phe Asp Val Gly Asn Gly Pro Phe Glu Ile Ser 
    850                 855                 860


Val Gln Ser Pro Thr His Phe Asn Asp Asn Gln Trp His His Val Arg 
865                 870                 875                 880


Val Glu Arg Asn Met Lys Glu Ala Ser Leu Gln Val Asp Gln Leu Thr 
                885                 890                 895


Pro Lys Thr Gln Pro Ala Pro Ala Asp Gly His Val Leu Leu Gln Leu 
            900                 905                 910


Asn Ser Gln Leu Phe Val Gly Gly Thr Ala Thr Arg Gln Arg Gly Phe 
        915                 920                 925


Leu Gly Cys Ile Arg Ser Leu Gln Leu Asn Gly Met Thr Leu Asp Leu 
    930                 935                 940


Glu Glu Arg Ala Gln Val Thr Pro Glu Val Gln Pro Gly Cys Arg Gly 
945                 950                 955                 960


His Cys Ser Ser Tyr Gly Lys Leu Cys Arg Asn Gly Gly Lys Cys Arg 
                965                 970                 975


Glu Arg Pro Ile Gly Phe Phe Cys Asp Cys Thr Phe Ser Ala Tyr Thr 
            980                 985                 990


Gly Pro Phe Cys Ser Asn Glu Ile Ser Ala Tyr Phe Gly Ser Gly Ser 
        995                 1000                1005


Ser Val Ile Tyr Asn Phe Gln Glu Asn Tyr Leu Leu Ser Lys Asn Ser 
    1010                1015                1020


Ser Ser His Ala Ala Ser Phe His Gly Asp Met Lys Leu Ser Arg Glu 
1025                1030                1035                1040


Met Ile Lys Phe Ser Phe Arg Thr Thr Arg Thr Pro Ser Leu Leu Leu 
                1045                1050                1055


Phe Val Ser Ser Phe Tyr Lys Glu Tyr Leu Ser Val Ile Ile Ala Lys 
            1060                1065                1070


Asn Gly Ser Leu Gln Ile Arg Tyr Lys Leu Asn Lys Tyr Gln Glu Pro 
        1075                1080                1085


Asp Val Val Asn Phe Asp Phe Lys Asn Met Ala Asp Gly Gln Leu His 
    1090                1095                1100


His Ile Met Ile Asn Arg Glu Glu Gly Val Val Phe Ile Glu Ile Asp 
1105                1110                1115                1120


Asp Asn Arg Arg Arg Gln Val His Leu Ser Ser Gly Thr Glu Phe Ser 
                1125                1130                1135


Ala Val Lys Ser Leu Val Leu Gly Arg Ile Leu Glu His Ser Asp Val 
            1140                1145                1150


Asp Gln Asp Thr Ala Leu Ala Gly Ala Gln Gly Phe Thr Gly Cys Leu 
        1155                1160                1165


Ser Ala Val Gln Leu Ser His Val Ala Pro Leu Lys Ala Ala Leu His 
    1170                1175                1180


Pro Ser His Pro Asp Pro Val Thr Val Thr Gly His Val Thr Glu Ser 
1185                1190                1195                1200


Ser Cys Met Ala Gln Pro Gly Thr Asp Ala Thr Ser Arg Glu Arg Thr 
                1205                1210                1215


His Ser Phe Ala Asp His Ser Gly Thr Ile Asp Asp Arg Glu Pro Leu 
            1220                1225                1230


Ala Asn Ala Ile Lys Ser Asp Ser Ala Val Ile Gly Gly Leu Ile Ala 
        1235                1240                1245


Val Val Ile Phe Ile Leu Leu Cys Ile Thr Ala Ile Ala Val Arg Ile 
    1250                1255                1260


Tyr Gln Gln Lys Arg Leu Tyr Lys Arg Ser Glu Ala Lys Arg Ser Glu 
1265                1270                1275                1280


Asn Val Asp Ser Ala Glu Ala Val Leu Lys Ser Glu Leu Asn Ile Gln 
                1285                1290                1295


Asn Ala Val Asn Glu Asn Gln Lys Glu Tyr Phe Phe 
            1300                1305


<210>  1095
<211>  4327
<212>  DNA
<213>  Homo sapiens

<400>  1095
gcttttgctg cttcctcatt ttctcttgca gccgccatga ttctgaggcc ttcccagcta     60

tgtggaacta tgactgtgat gatcctcttg tgtctgcctt gcctcaggca tccttcagca    120

gttcttccga gctctccagc agtcatggtc ctggatttgc aaggctgaat agaagagatg    180

gagctggtgg ctggtctcca cttgtgtcta acaaatacca gtggttgcag attgaccttg    240

gagagagaat ggaggtcacc gctgtggcca ctcaaggggg atatggtagc tccaactggg    300

tgaccagcta cctcctgatg ttcagtgata gtggctggaa ctggaaacaa tatcgccaag    360

aggacagcat ctggggtttt tcaggaaatg caaatgcaga cagtgttgtg tactatagac    420

tccagccttc tatcaaagcc agatttctgc gcttcatccc tttggaatgg aaccccaagg    480

gcagaattgg aatgcgaatc gaagtgttcg gatgtgcata cagatcagaa gtggttgatc    540

ttgatggaaa aagttccctt ctctacagat ttgatcaaaa atccctgagc ccaataaaag    600

acattatttc tttgaaattc aaaaccatgc agagtgatgg gattctactc cacagggaag    660

ggccaaatgg agatcacatc acactgcaat taagaagagc aagactcttt ttacttatta    720

attcaggtga agctaaactg ccttccactt ccaccctggt caatctcacc ctgggcagcc    780

tgctagatga tcagcattgg cattcagtgc tcatccagcg tttgggcaaa caagtcaact    840

tcacagtgga cgaacacagg catcatttcc atgcacgggg agaattcaat ctcatgaatc    900

ttgattatga gggaaatgtg tcattttctt gttcacaacc acaatctatg cccgtgactt    960

ttctgagctc caggagttat ttagcactgc cagacttctc tggagaggag gaggtttctg   1020

ccacttttca atttcgaact tggaataagg cagggcttct gctgttcagt gaacttcagc   1080

tgatttcagg gggtatcctc ctctttctga gtgatggaaa acttaagtcg aatctctacc   1140

agccaggaaa attacccagt gacatcacag caggtgtcga attaaatgat gggcagtggc   1200

attctgtctc tttatctgct aaaaagaatc acttgagtgt ggcggtggac ggccagatgg   1260

cttctgctgc tcctctgctg gggcctgagc agatttattc gggtggcacc tattattttg   1320

gaggttgtcc tgacaaaagc tttggatcca aatgtaaaag tccacttggt ggatttcagg   1380

gatgtatgag gctcatttct atcagcggca aagtggtaga tctgatttca gttcagcagg   1440

ggtcccttgg gaacttcagt gaccttcaga tagactcatg tggcatctca gacaggtgtt   1500

tgcccaacta ttgtgaacac ggtggggagt gttcccagtc ctggagcacc tttcattgta   1560

actgtaccaa cactggttac agaggagcta cttgccataa ctctatctat gagcagtcat   1620

gtgaagccta taagcacaga ggaaatactt cagggtttta ctatatagat tcagatggaa   1680

gtggtcccct ggaaccattt cttctatatt gcaatatgac cgaaactgca tggaccatca   1740

tacagcacaa cggctctgac ttaacaagag tcagaaatac taatccagag aacccatatg   1800

ctgggttttt cgagtatgtg gccagcatgg agcaacttca ggccactatt aaccgtgcag   1860

agcactgtga acaggagttt acttattact gcaagaagtc acggctggtc aataagcaag   1920

atggaacccc tctgagttgg tgggtaggaa gaaccaatga aacgcaaacc tactggggag   1980

gttcttcgcc tgatcttcaa aaatgtactt gtggattaga gggaaactgc attgattctc   2040

agtattactg caattgtgat gctgaccgga atgaatggac caatgacact ggattgcttg   2100

cttataaaga acatcttcca gtaactaaga tcgtgattac agacacaggc cgactgcatt   2160

cagaagcagc ttataaactg gggcctctgc tctgccaggg agacagatca ttttggaatt   2220

cagcttcctt tgataccgag gcttcatatc ttcattttcc taccttccac ggagaactta   2280

gcgcggatgt atctttcttt tttaagacaa cagcttcatc tggggtattt ttagagaact   2340

tggggattgc tgattttata cggatagagc ttcgctctcc gacagtagtg actttttcat   2400

ttgatgtggg gaatgggcct tttgaaatct cagtgcagtc acccacccac ttcaacgaca   2460

accagtggca ccatgtgagg gttgaaagga acatgaagga ggcctccctt caagtggatc   2520

agctgacacc aaagacacag cccgcccccg ctgatgggca tgtcctgtta cagctcaaca   2580

gtcagctctt cgtgggtgga acggccacca gacagagagg ctttctgggc tgcattcggt   2640

ctctgcagtt gaatgggatg accctggatt tggaagaaag agcccaggtg actccagaag   2700

tgcagccagg ttgtagggga cattgcagca gctatgggaa gttatgccgc aatggaggga   2760

aatgcagaga aagacccatt gggttctttt gtgactgcac tttctctgca tacacagggc   2820

cattctgctc aaatgagatt tctgcatatt ttggatctgg ctcatccgtg atatacaatt   2880

ttcaagaaaa ttatctttta agtaaaaact ccagctccca cgctgcttca tttcatggtg   2940

atatgaagct gagcagagaa atgatcaaat ttagtttccg aacaacacga acaccaagct   3000

tgctgctttt tgtgagctcc ttttacaaag aatacctttc tgtgatcatt gccaaaaatg   3060

gaagtttgca gatcaggtac aagttaaata aatatcaaga gcctgatgtt gttaactttg   3120

attttaaaaa catggctgat ggacaacttc accacataat gattaacaga gaagaaggag   3180

tggtctttat agagattgac gataatagaa ggagacaagt tcacctgtca tcaggcacag   3240

aattcagtgc agtcaaatct ctggtattgg gcaggatttt agaacacagt gatgtggacc   3300

aggatactgc actggcaggt gcgcagggct tcacaggctg cctctctgca gtgcagctca   3360

gccacgtggc ccctctgaag gcagctctgc accccagcca cccagaccct gtcactgtta   3420

caggacacgt gactgagtcc agctgtatgg cccagcctgg cactgatgcc acatcaaggg   3480

aaaggacaca ctcgtttgca gatcattctg gaacaataga tgacagagag ccccttgcta   3540

atgcaatcaa aagtgactct gcagtaattg gaggtctgat agctgttgtg atttttatct   3600

tgctttgcat cactgccata gctgttcgca tttatcagca gaaaaggtta tataaaagaa   3660

gtgaggcaaa aaggtcagag aatgtagaca gtgctgaggc tgttctgaaa agtgagctta   3720

atatacaaaa tgcagtcaat gaaaatcaga aagagtactt cttctgattg gcagctatga   3780

tttaacataa aattatgata gtttgtttta atagccaggg gttctcaatg gaaaaacgaa   3840

tgctcttaca ctgaatgtac aggcagtggg cttgcagcac tgccatcttg ccatgtacag   3900

gcttggggtg gctccaggaa gcctcgtcca gtgatatatt tctcatagca ttcattctat   3960

ggaacaagaa attagatatt gctgttaatt ttcaactgtt ctggtatgat ctaaaacaag   4020

tttaacctgc ttaatggcta cagtttttac atgtgaaaac tgtagccttg gtctcttaac   4080

catgtaatac ataagttttg ttagaggtaa aaattaaatt tggactataa tgtccttgct   4140

ttatttgaga acatttgctg tgtttgcttt tgtctcctcg tggtgttatt catagacctg   4200

gaaatgcttc tcagatcctg tgtggccggt gtttgcatct tcagtggcca caagcataat   4260

aaagcccctt tgcctttctc tgtattatat tcaatacaat acatcaatag tcttgaaaaa   4320

tgaaaaa                                                             4327


<210>  1096
<211>  1235
<212>  PRT
<213>  Homo sapiens

<400>  1096

Met Trp Asn Tyr Asp Cys Asp Asp Pro Leu Val Ser Ala Leu Pro Gln 
1               5                   10                  15


Ala Ser Phe Ser Ser Ser Ser Glu Leu Ser Ser Ser His Gly Pro Gly 
            20                  25                  30


Phe Ala Arg Leu Asn Arg Arg Asp Gly Ala Gly Gly Trp Ser Pro Leu 
        35                  40                  45


Val Ser Asn Lys Tyr Gln Trp Leu Gln Ile Asp Leu Gly Glu Arg Met 
    50                  55                  60


Glu Val Thr Ala Val Ala Thr Gln Gly Gly Tyr Gly Ser Ser Asn Trp 
65                  70                  75                  80


Val Thr Ser Tyr Leu Leu Met Phe Ser Asp Ser Gly Trp Asn Trp Lys 
                85                  90                  95


Gln Tyr Arg Gln Glu Asp Ser Ile Trp Gly Phe Ser Gly Asn Ala Asn 
            100                 105                 110


Ala Asp Ser Val Val Tyr Tyr Arg Leu Gln Pro Ser Ile Lys Ala Arg 
        115                 120                 125


Phe Leu Arg Phe Ile Pro Leu Glu Trp Asn Pro Lys Gly Arg Ile Gly 
    130                 135                 140


Met Arg Ile Glu Val Phe Gly Cys Ala Tyr Arg Ser Glu Val Val Asp 
145                 150                 155                 160


Leu Asp Gly Lys Ser Ser Leu Leu Tyr Arg Phe Asp Gln Lys Ser Leu 
                165                 170                 175


Ser Pro Ile Lys Asp Ile Ile Ser Leu Lys Phe Lys Thr Met Gln Ser 
            180                 185                 190


Asp Gly Ile Leu Leu His Arg Glu Gly Pro Asn Gly Asp His Ile Thr 
        195                 200                 205


Leu Gln Leu Arg Arg Ala Arg Leu Phe Leu Leu Ile Asn Ser Gly Glu 
    210                 215                 220


Ala Lys Leu Pro Ser Thr Ser Thr Leu Val Asn Leu Thr Leu Gly Ser 
225                 230                 235                 240


Leu Leu Asp Asp Gln His Trp His Ser Val Leu Ile Gln Arg Leu Gly 
                245                 250                 255


Lys Gln Val Asn Phe Thr Val Asp Glu His Arg His His Phe His Ala 
            260                 265                 270


Arg Gly Glu Phe Asn Leu Met Asn Leu Asp Tyr Glu Gly Asn Val Ser 
        275                 280                 285


Phe Ser Cys Ser Gln Pro Gln Ser Met Pro Val Thr Phe Leu Ser Ser 
    290                 295                 300


Arg Ser Tyr Leu Ala Leu Pro Asp Phe Ser Gly Glu Glu Glu Val Ser 
305                 310                 315                 320


Ala Thr Phe Gln Phe Arg Thr Trp Asn Lys Ala Gly Leu Leu Leu Phe 
                325                 330                 335


Ser Glu Leu Gln Leu Ile Ser Gly Gly Ile Leu Leu Phe Leu Ser Asp 
            340                 345                 350


Gly Lys Leu Lys Ser Asn Leu Tyr Gln Pro Gly Lys Leu Pro Ser Asp 
        355                 360                 365


Ile Thr Ala Gly Val Glu Leu Asn Asp Gly Gln Trp His Ser Val Ser 
    370                 375                 380


Leu Ser Ala Lys Lys Asn His Leu Ser Val Ala Val Asp Gly Gln Met 
385                 390                 395                 400


Ala Ser Ala Ala Pro Leu Leu Gly Pro Glu Gln Ile Tyr Ser Gly Gly 
                405                 410                 415


Thr Tyr Tyr Phe Gly Gly Cys Pro Asp Lys Ser Phe Gly Ser Lys Cys 
            420                 425                 430


Lys Ser Pro Leu Gly Gly Phe Gln Gly Cys Met Arg Leu Ile Ser Ile 
        435                 440                 445


Ser Gly Lys Val Val Asp Leu Ile Ser Val Gln Gln Gly Ser Leu Gly 
    450                 455                 460


Asn Phe Ser Asp Leu Gln Ile Asp Ser Cys Gly Ile Ser Asp Arg Cys 
465                 470                 475                 480


Leu Pro Asn Tyr Cys Glu His Gly Gly Glu Cys Ser Gln Ser Trp Ser 
                485                 490                 495


Thr Phe His Cys Asn Cys Thr Asn Thr Gly Tyr Arg Gly Ala Thr Cys 
            500                 505                 510


His Asn Ser Ile Tyr Glu Gln Ser Cys Glu Ala Tyr Lys His Arg Gly 
        515                 520                 525


Asn Thr Ser Gly Phe Tyr Tyr Ile Asp Ser Asp Gly Ser Gly Pro Leu 
    530                 535                 540


Glu Pro Phe Leu Leu Tyr Cys Asn Met Thr Glu Thr Ala Trp Thr Ile 
545                 550                 555                 560


Ile Gln His Asn Gly Ser Asp Leu Thr Arg Val Arg Asn Thr Asn Pro 
                565                 570                 575


Glu Asn Pro Tyr Ala Gly Phe Phe Glu Tyr Val Ala Ser Met Glu Gln 
            580                 585                 590


Leu Gln Ala Thr Ile Asn Arg Ala Glu His Cys Glu Gln Glu Phe Thr 
        595                 600                 605


Tyr Tyr Cys Lys Lys Ser Arg Leu Val Asn Lys Gln Asp Gly Thr Pro 
    610                 615                 620


Leu Ser Trp Trp Val Gly Arg Thr Asn Glu Thr Gln Thr Tyr Trp Gly 
625                 630                 635                 640


Gly Ser Ser Pro Asp Leu Gln Lys Cys Thr Cys Gly Leu Glu Gly Asn 
                645                 650                 655


Cys Ile Asp Ser Gln Tyr Tyr Cys Asn Cys Asp Ala Asp Arg Asn Glu 
            660                 665                 670


Trp Thr Asn Asp Thr Gly Leu Leu Ala Tyr Lys Glu His Leu Pro Val 
        675                 680                 685


Thr Lys Ile Val Ile Thr Asp Thr Gly Arg Leu His Ser Glu Ala Ala 
    690                 695                 700


Tyr Lys Leu Gly Pro Leu Leu Cys Gln Gly Asp Arg Ser Phe Trp Asn 
705                 710                 715                 720


Ser Ala Ser Phe Asp Thr Glu Ala Ser Tyr Leu His Phe Pro Thr Phe 
                725                 730                 735


His Gly Glu Leu Ser Ala Asp Val Ser Phe Phe Phe Lys Thr Thr Ala 
            740                 745                 750


Ser Ser Gly Val Phe Leu Glu Asn Leu Gly Ile Ala Asp Phe Ile Arg 
        755                 760                 765


Ile Glu Leu Arg Ser Pro Thr Val Val Thr Phe Ser Phe Asp Val Gly 
    770                 775                 780


Asn Gly Pro Phe Glu Ile Ser Val Gln Ser Pro Thr His Phe Asn Asp 
785                 790                 795                 800


Asn Gln Trp His His Val Arg Val Glu Arg Asn Met Lys Glu Ala Ser 
                805                 810                 815


Leu Gln Val Asp Gln Leu Thr Pro Lys Thr Gln Pro Ala Pro Ala Asp 
            820                 825                 830


Gly His Val Leu Leu Gln Leu Asn Ser Gln Leu Phe Val Gly Gly Thr 
        835                 840                 845


Ala Thr Arg Gln Arg Gly Phe Leu Gly Cys Ile Arg Ser Leu Gln Leu 
    850                 855                 860


Asn Gly Met Thr Leu Asp Leu Glu Glu Arg Ala Gln Val Thr Pro Glu 
865                 870                 875                 880


Val Gln Pro Gly Cys Arg Gly His Cys Ser Ser Tyr Gly Lys Leu Cys 
                885                 890                 895


Arg Asn Gly Gly Lys Cys Arg Glu Arg Pro Ile Gly Phe Phe Cys Asp 
            900                 905                 910


Cys Thr Phe Ser Ala Tyr Thr Gly Pro Phe Cys Ser Asn Glu Ile Ser 
        915                 920                 925


Ala Tyr Phe Gly Ser Gly Ser Ser Val Ile Tyr Asn Phe Gln Glu Asn 
    930                 935                 940


Tyr Leu Leu Ser Lys Asn Ser Ser Ser His Ala Ala Ser Phe His Gly 
945                 950                 955                 960


Asp Met Lys Leu Ser Arg Glu Met Ile Lys Phe Ser Phe Arg Thr Thr 
                965                 970                 975


Arg Thr Pro Ser Leu Leu Leu Phe Val Ser Ser Phe Tyr Lys Glu Tyr 
            980                 985                 990


Leu Ser Val Ile Ile Ala Lys Asn Gly Ser Leu Gln Ile Arg Tyr Lys 
        995                 1000                1005


Leu Asn Lys Tyr Gln Glu Pro Asp Val Val Asn Phe Asp Phe Lys Asn 
    1010                1015                1020


Met Ala Asp Gly Gln Leu His His Ile Met Ile Asn Arg Glu Glu Gly 
1025                1030                1035                1040


Val Val Phe Ile Glu Ile Asp Asp Asn Arg Arg Arg Gln Val His Leu 
                1045                1050                1055


Ser Ser Gly Thr Glu Phe Ser Ala Val Lys Ser Leu Val Leu Gly Arg 
            1060                1065                1070


Ile Leu Glu His Ser Asp Val Asp Gln Asp Thr Ala Leu Ala Gly Ala 
        1075                1080                1085


Gln Gly Phe Thr Gly Cys Leu Ser Ala Val Gln Leu Ser His Val Ala 
    1090                1095                1100


Pro Leu Lys Ala Ala Leu His Pro Ser His Pro Asp Pro Val Thr Val 
1105                1110                1115                1120


Thr Gly His Val Thr Glu Ser Ser Cys Met Ala Gln Pro Gly Thr Asp 
                1125                1130                1135


Ala Thr Ser Arg Glu Arg Thr His Ser Phe Ala Asp His Ser Gly Thr 
            1140                1145                1150


Ile Asp Asp Arg Glu Pro Leu Ala Asn Ala Ile Lys Ser Asp Ser Ala 
        1155                1160                1165


Val Ile Gly Gly Leu Ile Ala Val Val Ile Phe Ile Leu Leu Cys Ile 
    1170                1175                1180


Thr Ala Ile Ala Val Arg Ile Tyr Gln Gln Lys Arg Leu Tyr Lys Arg 
1185                1190                1195                1200


Ser Glu Ala Lys Arg Ser Glu Asn Val Asp Ser Ala Glu Ala Val Leu 
                1205                1210                1215


Lys Ser Glu Leu Asn Ile Gln Asn Ala Val Asn Glu Asn Gln Lys Glu 
            1220                1225                1230


Tyr Phe Phe 
        1235


<210>  1097
<211>  1787
<212>  DNA
<213>  Homo sapiens

<400>  1097
gttggacatc agctggggct ggagtcacct gcaggctggc ctggggtcgg gcagggggat     60

ctgcttccaa ggctctgctt cagaggcggc tccctcccac ggtaggcgca tggtttcctg    120

tctccaaagt gggcctctgc acaaggctgc ttggatgacc tcatgatatg gtggctgctg    180

accagggtag aggctggaac cccttggatg gcccaacctg ggaggtacta gccatgcctc    240

tgccattggg cccggccaca caggttcctg ccctcttctc cgctgccctt gtgcctcccg    300

tgtcctcgct gcgtcctaac caaatgctgg actggcagag actgaaaacg ccccacgggg    360

cccctgtggc ttgctcactc gggctctccg gagagtgggt gccaaccccc tgcgccctga    420

gcatcttggc tctgcttggc ttgcagctgg atcccctttt tggactttgg ggctgcacac    480

gcaccttgtt ctggagcgaa tgggctcgtg agagccgcag gccctgaggc atggcctaac    540

tcaggcagag tagttggcga aggccccaga gggacccagg ctatcgtcct gcagctgccg    600

gcaaaaccat caacggatgc tgacatcagc gagcaaaagt gtgatgaaga acggcgattt    660

gcatcgtttc aaagtatctc tccatgagat acttactaat ttcaaagggg acaatggcca    720

ggtgaagcct ggcagatgtc acttacactg agtgatccat gttgccatct ccagggtgac    780

acggtgtgcc tgtgacatga agcgccaagg ggaacccaat gtcatttctg gggttcttcc    840

tgccccaaac agtccatttg gttaaactca cgagagtgtg tgcttgtcga tgtagctgat    900

tctgtatggg tggggatttg gaccagccct tcactactca aagtggggtc tgtacaccag    960

cagcagggtt acctccttaa ccccgagctt gtaagaaagc acagccaagc atggtggctc   1020

atgtttgtaa tcctagcact ttgggaggct gaggtgggtg gatcatctga ggtcaggagt   1080

ttgagaccag cctggccaac atgatgaaac cccgtttcta ctaaaaatac aaaaattagc   1140

caggcgtggt gatgggtgcc tgtaatccca gctacgtggg aggctgaggc aggagaatca   1200

cttgaaccca gaaggtgcag gttgcagtga gctgagatcg tgccactgca ctccagcctg   1260

ggcgacaaga gcgaaactct gtctcaaaaa aaaaaaaaaa aaagaaagaa agaaagaaag   1320

aaattaagag tctcgggccc tgccccagac ctagaatcag gacctgcatg ttaacaaacc   1380

ccacatctgt gatccctgtc cacagtaaag gctgagaatg cttaatccaa aacaccttcc   1440

gcctcccaga gcttgtggct ttgatgccat ttgtctgaac atcacaagga accacgtggg   1500

aaaacaggac ttcgtggcgt gccctggcag acaagccaaa gcaactgtgg gcatcaggct   1560

gtggggcggc atccctagga ctcagaataa tgcctgcgca cagtaggcac ggaagtattt   1620

gtggaaggaa gaaatggaga tcatcatgaa ataagcgcta ttggccgggc acggtggctc   1680

acgcctgtaa tcccagcact tcgggaggcc gaggtaggcg gatcacctga ggttaggagt   1740

tcgagaccag cctggccaac atgatgaaac cttatctcta ctaaaaa                 1787


<210>  1098
<211>  981
<212>  DNA
<213>  Homo sapiens

<400>  1098
atgaggatta tccggggggc cctgagtgta acagtgagga ttatgcaggg gggccctgag     60

tgtaacaatg aggattatcc ggggggccct gagtgtaacg gtgaggatta tccggggggc    120

cctgagtgta acggtgagga ttattcaggg ggccctgagt gcaacggtga ggattattca    180

ggggggcctg agagtaacag tgaggattat ccaggggggc ctgagagtaa cagtgaggat    240

tatccagggg ggcctgagag taacactaac agtgaggatt atccgggggg cctgagtgta    300

acagtgagga ttatccaggg gggccctgag agtaacagcg aggattatcc ggggggccct    360

gagtgcaaca gtgaggatta tccagggggg cctgagagta acagtgagga ttatccaggg    420

gggcctgaga gtaacagtga ggattatcca ggggggcctg agagtaacat aacagtgagg    480

attatccagg ggggccctga gtgtaacagt gaggattatc cagggggccc tgagtgtaac    540

agtgaggatt atcagaggga ccctgagtgc aacagtgagg attatccggg gggcctgaga    600

gtaacagtga ggattatcca ggggggccct gagtgtaaca gtgaggatta tccagggggc    660

cctgagtgta acagtgagga ttatcagagg gaccctgagt gcaacagggg ccctgagtgt    720

aacagcgagg attatccagg ggggcctgag agtaacagtg aggattatcc aggggggcct    780

gagagtaaca gtgaggatta tccagggggg cctgagagta acagtgagga ttatccaggt    840

gccctgagtg taacagtgag gattatccag gggggccctg agtgtaacag cgaggattat    900

ccagggggcc ctgagtgcaa cagtgaggat tatccagggg ggcctgagtg taacagtgag    960

gattatccag gggggccctg a                                              981


<210>  1099
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  1099

Met Arg Ile Ile Arg Gly Ala Leu Ser Val Thr Val Arg Ile Met Gln 
1               5                   10                  15


Gly Gly Pro Glu Cys Asn Asn Glu Asp Tyr Pro Gly Gly Pro Glu Cys 
            20                  25                  30


Asn Gly Glu Asp Tyr Pro Gly Gly Pro Glu Cys Asn Gly Glu Asp Tyr 
        35                  40                  45


Ser Gly Gly Pro Glu Cys Asn Gly Glu Asp Tyr Ser Gly Gly Pro Glu 
    50                  55                  60


Ser Asn Ser Glu Asp Tyr Pro Gly Gly Pro Glu Ser Asn Ser Glu Asp 
65                  70                  75                  80


Tyr Pro Gly Gly Pro Glu Ser Asn Thr Asn Ser Glu Asp Tyr Pro Gly 
                85                  90                  95


Gly Leu Ser Val Thr Val Arg Ile Ile Gln Gly Gly Pro Glu Ser Asn 
            100                 105                 110


Ser Glu Asp Tyr Pro Gly Gly Pro Glu Cys Asn Ser Glu Asp Tyr Pro 
        115                 120                 125


Gly Gly Pro Glu Ser Asn Ser Glu Asp Tyr Pro Gly Gly Pro Glu Ser 
    130                 135                 140


Asn Ser Glu Asp Tyr Pro Gly Gly Pro Glu Ser Asn Ile Thr Val Arg 
145                 150                 155                 160


Ile Ile Gln Gly Gly Pro Glu Cys Asn Ser Glu Asp Tyr Pro Gly Gly 
                165                 170                 175


Pro Glu Cys Asn Ser Glu Asp Tyr Gln Arg Asp Pro Glu Cys Asn Ser 
            180                 185                 190


Glu Asp Tyr Pro Gly Gly Leu Arg Val Thr Val Arg Ile Ile Gln Gly 
        195                 200                 205


Gly Pro Glu Cys Asn Ser Glu Asp Tyr Pro Gly Gly Pro Glu Cys Asn 
    210                 215                 220


Ser Glu Asp Tyr Gln Arg Asp Pro Glu Cys Asn Arg Gly Pro Glu Cys 
225                 230                 235                 240


Asn Ser Glu Asp Tyr Pro Gly Gly Pro Glu Ser Asn Ser Glu Asp Tyr 
                245                 250                 255


Pro Gly Gly Pro Glu Ser Asn Ser Glu Asp Tyr Pro Gly Gly Pro Glu 
            260                 265                 270


Ser Asn Ser Glu Asp Tyr Pro Gly Ala Leu Ser Val Thr Val Arg Ile 
        275                 280                 285


Ile Gln Gly Gly Pro Glu Cys Asn Ser Glu Asp Tyr Pro Gly Gly Pro 
    290                 295                 300


Glu Cys Asn Ser Glu Asp Tyr Pro Gly Gly Pro Glu Cys Asn Ser Glu 
305                 310                 315                 320


Asp Tyr Pro Gly Gly Pro 
                325


<210>  1100
<211>  1941
<212>  DNA
<213>  Homo sapiens

<400>  1100
cttcccagag gcgcgagtcg cttttccagg agccgaggcc caaacggggc cgggcctgaa     60

gggtcccccg ccagcccgcg gccgcgccat caatcgccgc cgcctcgtcc cgcttctcgg    120

ctgaggcgcc gcgcggccag gcagcgggtc caggcctcag ccgcgcgccc aggggcctcc    180

ggggccctcc cgggtcagca tgcccggggt gaaactgacc acccaggcct actgcaagat    240

ggtgctgcac ggcgccaagt acccgcactg cgccgtcaac gggctcctgg tggccgagaa    300

gcagaagccg cgtaaggagc acctccccct gggcggcccc ggcgcccacc acaccctctt    360

cgtggactgc atccccctct tccacggcac cctggccctc gcccccatgc tggaggtggc    420

tctcaccctg attgattcat ggtgcaaaga tcatagctac gtgattgctg gttattatca    480

agctaatgag cgagtaaagg atgccagtcc aaaccaggtt gcagagaagg tggcctccag    540

aatcgccgag ggcttcagcg acactgcgct catcatggta gacaacacca agtttacgat    600

ggactgcgta gcgcctacga tccacgtgta cgagcaccat gagaacagat ggcggtgcag    660

agacccacac catgactact gtgaagactg gccagaggca cagaggatct cagcctcgct    720

cctggacagc cggtcctacg agacgctcgt ggatttcgat aaccacctgg atgacattcg    780

gaatgactgg acaaacccag agatcaataa agctgtccta cacttgtgct aggcaggcac    840

cgctgtgact gggctccggg cctttccact acgttgaaga agaaaaccta tttttaaatg    900

taaataaaat atctggtagc ctgtgtggaa agctgaccgt tttaagaagt ggcatgtgcc    960

ttgaaagggg gcagaatgtt cagtcggtcg tgtttttaac acagagtctc tagaagaggt   1020

gcagacatcc cgtctgactg tccctgtgga ctctctcagt tgtatgttgc tataatcctc   1080

caaatcaaag ctctttctgc ttgtgcaaga ttgttcctat taaacagttt taactaacct   1140

tttataatct ggagagaata ctttttaagg cttttgaact atcttttttt aaaaaaaaaa   1200

aaaagcccac atcttatact ccaatgagtg tgtttgtgag tttttatcct gtttgaattt   1260

tgatgtcgtc caggcgtcct gggatcaggg tagacacgtg gagtgctggt gctgagctgt   1320

ttgagaagct ctgtgtgggt gtttctgtgg tcaggtaggc tgggctgtga acagcactgc   1380

tccacatggt gtcggctcac agagccaccg caactctgcc cagcgggagt gacaccactg   1440

atgccacaga agcctttatc gttaggggca aaagcagaca tctctggtag caggagctca   1500

gtgtggtgct cttcagccac gcagaaagct cacgtgcctg cagggccagg aaagggaaat   1560

gatcgtttct tttgtattag gaaaaacaag acttagactt cccgagttgt gcagagtgac   1620

gtctgtactt tttatactta gaacatttgg tcaagttttg taaccaaacc ttagggaatt   1680

gagagggaaa ctttatggta cgtttacctt ttttcctttt tatatgaatt attttgtaca   1740

aagttcagag agcggtacct ttcctactgt cttttctttg actccatgga ggaatttgta   1800

acgatcggtg tgacctgaaa gggtttgtga tacagcggtc actattttct cttaacacat   1860

aggaaaaaag ttcagacatc gctacaataa atgtgcttta tttgatccaa aaaaaaaaaa   1920

aaaaaaaaaa aaaaaaaaaa a                                             1941


<210>  1101
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  1101

Met Pro Gly Val Lys Leu Thr Thr Gln Ala Tyr Cys Lys Met Val Leu 
1               5                   10                  15


His Gly Ala Lys Tyr Pro His Cys Ala Val Asn Gly Leu Leu Val Ala 
            20                  25                  30


Glu Lys Gln Lys Pro Arg Lys Glu His Leu Pro Leu Gly Gly Pro Gly 
        35                  40                  45


Ala His His Thr Leu Phe Val Asp Cys Ile Pro Leu Phe His Gly Thr 
    50                  55                  60


Leu Ala Leu Ala Pro Met Leu Glu Val Ala Leu Thr Leu Ile Asp Ser 
65                  70                  75                  80


Trp Cys Lys Asp His Ser Tyr Val Ile Ala Gly Tyr Tyr Gln Ala Asn 
                85                  90                  95


Glu Arg Val Lys Asp Ala Ser Pro Asn Gln Val Ala Glu Lys Val Ala 
            100                 105                 110


Ser Arg Ile Ala Glu Gly Phe Ser Asp Thr Ala Leu Ile Met Val Asp 
        115                 120                 125


Asn Thr Lys Phe Thr Met Asp Cys Val Ala Pro Thr Ile His Val Tyr 
    130                 135                 140


Glu His His Glu Asn Arg Trp Arg Cys Arg Asp Pro His His Asp Tyr 
145                 150                 155                 160


Cys Glu Asp Trp Pro Glu Ala Gln Arg Ile Ser Ala Ser Leu Leu Asp 
                165                 170                 175


Ser Arg Ser Tyr Glu Thr Leu Val Asp Phe Asp Asn His Leu Asp Asp 
            180                 185                 190


Ile Arg Asn Asp Trp Thr Asn Pro Glu Ile Asn Lys Ala Val Leu His 
        195                 200                 205


Leu Cys 
    210


<210>  1102
<211>  708
<212>  DNA
<213>  Homo sapiens

<400>  1102
atggcgcggc cgcgggctgg cgggggaccc ttcaggcccg gccccgtttg ggcctcggct     60

cctggaaaag cgactcgcgc ctctgggaag ccgcagcccc agactccagt cgcgcttctc    120

gcccggcgcc gccggaaagc agcctctcca acgcctgccg gaaagcagcc cggcccggca    180

ttttacgacg ttcgcagcgc tacccttttc cgctccacgg tgacctccgt gcggccgggt    240

gcgggcggag tcttcctcga tcccgtggtg ctccgcggcg cggccttgct ctcttccggt    300

cgcgggacac cgggtgtaga gggcggtcgc ggcgggcagt ggcggcaggt gagacaggag    360

gtggccggtg cggcgccgcc aggccgggcc gggtcggggg gccgggagcc atcaagtctg    420

cacgtccgca gcctggccgc tcggcttcag caggaagcac cgaatgggcc tcggagccag    480

gtgacattga ggccggcccg tggggactcc gggctcggtg gctccaggct cggggggccg    540

ccccgaagtg cccggtccat cttacccggt ctcgcagcgg ctgcggaccg gcctcgggca    600

ctgaccttgg agcgcccgct ggccgagggc tcaggctgcg gggaggcggg cccgcgctct    660

gtgcctgcag cctccgccct tgctccttca aaagggattg gaaattga                 708


<210>  1103
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  1103

Met Ala Arg Pro Arg Ala Gly Gly Gly Pro Phe Arg Pro Gly Pro Val 
1               5                   10                  15


Trp Ala Ser Ala Pro Gly Lys Ala Thr Arg Ala Ser Gly Lys Pro Gln 
            20                  25                  30


Pro Gln Thr Pro Val Ala Leu Leu Ala Arg Arg Arg Arg Lys Ala Ala 
        35                  40                  45


Ser Pro Thr Pro Ala Gly Lys Gln Pro Gly Pro Ala Phe Tyr Asp Val 
    50                  55                  60


Arg Ser Ala Thr Leu Phe Arg Ser Thr Val Thr Ser Val Arg Pro Gly 
65                  70                  75                  80


Ala Gly Gly Val Phe Leu Asp Pro Val Val Leu Arg Gly Ala Ala Leu 
                85                  90                  95


Leu Ser Ser Gly Arg Gly Thr Pro Gly Val Glu Gly Gly Arg Gly Gly 
            100                 105                 110


Gln Trp Arg Gln Val Arg Gln Glu Val Ala Gly Ala Ala Pro Pro Gly 
        115                 120                 125


Arg Ala Gly Ser Gly Gly Arg Glu Pro Ser Ser Leu His Val Arg Ser 
    130                 135                 140


Leu Ala Ala Arg Leu Gln Gln Glu Ala Pro Asn Gly Pro Arg Ser Gln 
145                 150                 155                 160


Val Thr Leu Arg Pro Ala Arg Gly Asp Ser Gly Leu Gly Gly Ser Arg 
                165                 170                 175


Leu Gly Gly Pro Pro Arg Ser Ala Arg Ser Ile Leu Pro Gly Leu Ala 
            180                 185                 190


Ala Ala Ala Asp Arg Pro Arg Ala Leu Thr Leu Glu Arg Pro Leu Ala 
        195                 200                 205


Glu Gly Ser Gly Cys Gly Glu Ala Gly Pro Arg Ser Val Pro Ala Ala 
    210                 215                 220


Ser Ala Leu Ala Pro Ser Lys Gly Ile Gly Asn 
225                 230                 235


<210>  1104
<211>  802
<212>  DNA
<213>  Homo sapiens

<400>  1104
cgacgttcgc agcgctaccc ttttccgctc cacggtgacc tccgtgcggc cgggtgcggg     60

cggagtcttc ctcgatcccg tggtgctccg cggcgcggcc ttgctctctt ccggtcgcgg    120

gacaccgggt gtagagggcg gtcgcggcgg gcagtggcgg cagaatgttg gctaccaggg    180

tatttagcct agttggcaag cgagcaattt ccacctctgt gtgtgtacga gctcatgaaa    240

gtgttgtgaa gagcgaagac ttttcgctcc cagcttatat ggatcggcgt gaccacccct    300

tgccggaggt ggcccatgtc aagcacctgt ctgccagcca gaaggcactg aaggagaagg    360

agaaggcctc ctggagcagc ctctccatgg atgagaaagt cgagttgtat cgcattaagt    420

tcaaggagag ctttgctgag atgaacaggg gctcgaacga gtggaagacg gttgtgggcg    480

gtgccatgtt cttcatcggt ttcaccgcgc tcgttatcat gtggcagaag cactatgtgt    540

acggccccct cccgcaaagc tttgacaaag agtgggtggc caagcagacc aagaggatgc    600

tggacatgaa ggtgaacccc atccagggct tagcctccaa gtgggactac gaaaagaacg    660

agtggaagaa gtgagagatg ctggcctgcg cctgcacctg cgcctggctc tgtcaccgcc    720

atgcaactcc atgcctattt actggaaacc tgttatgcca aacagttgta ccactgctaa    780

taaatgacca gtttacctga aa                                             802


<210>  1105
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  1105

Met Leu Ala Thr Arg Val Phe Ser Leu Val Gly Lys Arg Ala Ile Ser 
1               5                   10                  15


Thr Ser Val Cys Val Arg Ala His Glu Ser Val Val Lys Ser Glu Asp 
            20                  25                  30


Phe Ser Leu Pro Ala Tyr Met Asp Arg Arg Asp His Pro Leu Pro Glu 
        35                  40                  45


Val Ala His Val Lys His Leu Ser Ala Ser Gln Lys Ala Leu Lys Glu 
    50                  55                  60


Lys Glu Lys Ala Ser Trp Ser Ser Leu Ser Met Asp Glu Lys Val Glu 
65                  70                  75                  80


Leu Tyr Arg Ile Lys Phe Lys Glu Ser Phe Ala Glu Met Asn Arg Gly 
                85                  90                  95


Ser Asn Glu Trp Lys Thr Val Val Gly Gly Ala Met Phe Phe Ile Gly 
            100                 105                 110


Phe Thr Ala Leu Val Ile Met Trp Gln Lys His Tyr Val Tyr Gly Pro 
        115                 120                 125


Leu Pro Gln Ser Phe Asp Lys Glu Trp Val Ala Lys Gln Thr Lys Arg 
    130                 135                 140


Met Leu Asp Met Lys Val Asn Pro Ile Gln Gly Leu Ala Ser Lys Trp 
145                 150                 155                 160


Asp Tyr Glu Lys Asn Glu Trp Lys Lys 
                165


<210>  1106
<211>  1652
<212>  DNA
<213>  Homo sapiens

<400>  1106
cctcaggtgg atcgccgcgg cccctcctcc cagagcggca gccttttccc gcgcgtgctg     60

ccttcgccgc tcgggccgcc cgggggaaaa catggcgtct gccctggagc agttcgtgaa    120

cagtgtccga cagctctcag ctcaagggca aatgacacag ctttgtgaac tgatcaacaa    180

gagtggggaa ctccttgcga agaacttatc ccatctggac actgtgctcg gggctctgga    240

tgtacaagaa cactccttgg gcgtccttgc tgttttgttt gtgaagtttt ctatgcccag    300

tgttcctgac ttcgaaacgc tattctcaca ggttcagctc ttcatcagca cttgtaatgg    360

ggagcacatt cgatatgcaa cagacacttt tgctgggctt tgccatcagc taacaaatgc    420

acttgtggaa agaaaacagc ccctgcgagg aattggcatc cttaagcaag ccatagacaa    480

gatgcagatg aatacaaacc agctgacctc aatacatgct gatctctgcc agctttgttt    540

gctagcaaaa tgctttaagc ctgcccttcc atatcttgac gtggatatga tggatatctg    600

taaagagaat ggagcctatg atgcaaaaca ctttttatgt tactattatt atggagggat    660

gatctatact gggctgaaga actttgaaag agctctctac ttttatgaac aggctataac    720

tactcctgcc atggcggtca gtcatatcat gttggaatca tataaaaagt atattttagt    780

gtctttgata ttacttggca aagtacaaca gctaccaaaa tatacatctc aaattgtggg    840

tagattcatt aagcctctta gcaatgcata ccacgagtta gcacaagtgt attcaaccaa    900

caacccctca gaactccgaa acctggtgaa taagcacagt gaaaccttca ctcgcgataa    960

caacatgggg ctggtgaagc aatgcttgtc atctctttat aagaagaata ttcagaggct   1020

aacaaagacc tttttaactc tatcattaca agatatggca agtcgtgtgc agttgtctgg   1080

acctcaggag gcagagaaat acgttctgca catgatagaa gatggtgaga tttttgcaag   1140

tattaaccag aaggacggta tggtcagttt ccatgataac cctgaaaaat ataataaccc   1200

agccatgctt cataacattg atcaggagat gctgaagtgc attgagctgg atgagcggct   1260

gaaagccatg gaccaggaga tcacagtgaa ccctcagttt gtacaaaaga gtatgggctc   1320

acaagaagat gattcaggaa acaaaccatc cagttattct tgaaactaac atccatcctg   1380

agctaaacaa gagaaactac catcttggcc agtgacaagt gttcggaggg cagcagagag   1440

gaccaagcct gtgtcacctg gagactaaga aattaagttt tgttttgaca tcttcagtcc   1500

tgtgtgcttt cagaaaacca ttttctctgc aaagaaagga aacagatttg caaactttaa   1560

agtctgtcgt ggatttattt atcctcagat tattgttact gcattaaatc tacctttttg   1620

ttttaagttg cttgaaaaaa aaaaaaaaaa aa                                 1652


<210>  1107
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  1107

Met Ala Ser Ala Leu Glu Gln Phe Val Asn Ser Val Arg Gln Leu Ser 
1               5                   10                  15


Ala Gln Gly Gln Met Thr Gln Leu Cys Glu Leu Ile Asn Lys Ser Gly 
            20                  25                  30


Glu Leu Leu Ala Lys Asn Leu Ser His Leu Asp Thr Val Leu Gly Ala 
        35                  40                  45


Leu Asp Val Gln Glu His Ser Leu Gly Val Leu Ala Val Leu Phe Val 
    50                  55                  60


Lys Phe Ser Met Pro Ser Val Pro Asp Phe Glu Thr Leu Phe Ser Gln 
65                  70                  75                  80


Val Gln Leu Phe Ile Ser Thr Cys Asn Gly Glu His Ile Arg Tyr Ala 
                85                  90                  95


Thr Asp Thr Phe Ala Gly Leu Cys His Gln Leu Thr Asn Ala Leu Val 
            100                 105                 110


Glu Arg Lys Gln Pro Leu Arg Gly Ile Gly Ile Leu Lys Gln Ala Ile 
        115                 120                 125


Asp Lys Met Gln Met Asn Thr Asn Gln Leu Thr Ser Ile His Ala Asp 
    130                 135                 140


Leu Cys Gln Leu Cys Leu Leu Ala Lys Cys Phe Lys Pro Ala Leu Pro 
145                 150                 155                 160


Tyr Leu Asp Val Asp Met Met Asp Ile Cys Lys Glu Asn Gly Ala Tyr 
                165                 170                 175


Asp Ala Lys His Phe Leu Cys Tyr Tyr Tyr Tyr Gly Gly Met Ile Tyr 
            180                 185                 190


Thr Gly Leu Lys Asn Phe Glu Arg Ala Leu Tyr Phe Tyr Glu Gln Ala 
        195                 200                 205


Ile Thr Thr Pro Ala Met Ala Val Ser His Ile Met Leu Glu Ser Tyr 
    210                 215                 220


Lys Lys Tyr Ile Leu Val Ser Leu Ile Leu Leu Gly Lys Val Gln Gln 
225                 230                 235                 240


Leu Pro Lys Tyr Thr Ser Gln Ile Val Gly Arg Phe Ile Lys Pro Leu 
                245                 250                 255


Ser Asn Ala Tyr His Glu Leu Ala Gln Val Tyr Ser Thr Asn Asn Pro 
            260                 265                 270


Ser Glu Leu Arg Asn Leu Val Asn Lys His Ser Glu Thr Phe Thr Arg 
        275                 280                 285


Asp Asn Asn Met Gly Leu Val Lys Gln Cys Leu Ser Ser Leu Tyr Lys 
    290                 295                 300


Lys Asn Ile Gln Arg Leu Thr Lys Thr Phe Leu Thr Leu Ser Leu Gln 
305                 310                 315                 320


Asp Met Ala Ser Arg Val Gln Leu Ser Gly Pro Gln Glu Ala Glu Lys 
                325                 330                 335


Tyr Val Leu His Met Ile Glu Asp Gly Glu Ile Phe Ala Ser Ile Asn 
            340                 345                 350


Gln Lys Asp Gly Met Val Ser Phe His Asp Asn Pro Glu Lys Tyr Asn 
        355                 360                 365


Asn Pro Ala Met Leu His Asn Ile Asp Gln Glu Met Leu Lys Cys Ile 
    370                 375                 380


Glu Leu Asp Glu Arg Leu Lys Ala Met Asp Gln Glu Ile Thr Val Asn 
385                 390                 395                 400


Pro Gln Phe Val Gln Lys Ser Met Gly Ser Gln Glu Asp Asp Ser Gly 
                405                 410                 415


Asn Lys Pro Ser Ser Tyr Ser 
            420


<210>  1108
<211>  1633
<212>  DNA
<213>  Homo sapiens

<400>  1108
cggcctcgct ctggggccgg tacttgcgcg cccgcacccc gcgctccccg ccccgctccc     60

cgtcccgcgc tccacgcgcg ccccagcgtt gggggcttct cctccgcggc gggaatgtct    120

ggccggctcc ggcagcacgg cgcggcccag gtccccgcgc ccacgacggg ccagcgcgct    180

gggccatgat ccggctgggc ggctggtgtg cgcggcggct ctgcagcgcg gcggttcccg    240

cggggcggcg cggggcggcg ggcgggctgg gcctggcggg aggccgcgcc ctacgggtgc    300

tggtggacat ggacggcgtg ctggctgact tcgagggcgg attcctcagg aagttccgcg    360

cgcgctttcc cgaccagccc ttcatcgcgc tggaggaccg gcgcggcttc tgggtgtcgg    420

agcagtacgg ccgcctgcgg ccagggctga gcgagaaggc catcagcatt tgggagtcaa    480

agaatttctt ttttgaactt gagcctctgc caggggccgt ggaagctgtc aaggagatgg    540

ccagcctaca aaacactgac gtcttcatct gcacaagccc catcaagatg ttcaagtact    600

gtccctatga gaagtatgcc tgggtggaga agtactttgg ccctgacttt ctggagcaga    660

ttgtgctgac cagagacaag accgtggtct ctgctgacct tctcatagac gaccggccgg    720

acatcacagg ggccgagcca acccccagct gggagcatgt cctcttcacc gcctgccaca    780

accagcacct gcagctgcag cccccccgcc gcaggctgca ctcgtgggcg gacgactgga    840

aggccattct ggacagcaag cggccctgct gagctggact gtgcttcggg ctcctctgtg    900

gggctctgac ctcagggctc ccagctcggg gcctgtgggg ccagtatgct ggtctgggag    960

tccctcctag actcctgggc cccatgacct cctgctgcat gtcccttccc ttccccagcc   1020

ctgccaggcc ttaacctgat cacggggcag ggctgggccc tctgggcgct tggacataga   1080

cacgtggtcc caggccgttc agcctgacct caggcagcag gcaccaagct gccagaagcc   1140

caggggctca ggacagggag gagttgaggc cactgttcag ggggctggtg gccgtctcca   1200

ctccctaggc aagttctctg aggcagaagg gggttccctg ttcccagagt ctgcagccat   1260

cagcaaggag gaccaggaac ccggcgactg aggtgcttcc aggtggggac aagcccctct   1320

tggtctcagc cacagcaccc cttattccag ctgccctgcc caacctgctc accccacatg   1380

accttctgtg tattcagcaa acactcacta ggtgacagcg gccaccaggc tctgtgctgg   1440

gggacgatac tggccctggc ctcgaccagc ttagaggttt ctcacacctc tgttcccagg   1500

gccccgctca gggcccagca gagagtccgt aggcttgaac atgtgttgag tgcatgaaaa   1560

ataaatgctg ttcatgtgtg tagctcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1620

aaaaaaaaaa aaa                                                      1633


<210>  1109
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  1109

Met Ile Arg Leu Gly Gly Trp Cys Ala Arg Arg Leu Cys Ser Ala Ala 
1               5                   10                  15


Val Pro Ala Gly Arg Arg Gly Ala Ala Gly Gly Leu Gly Leu Ala Gly 
            20                  25                  30


Gly Arg Ala Leu Arg Val Leu Val Asp Met Asp Gly Val Leu Ala Asp 
        35                  40                  45


Phe Glu Gly Gly Phe Leu Arg Lys Phe Arg Ala Arg Phe Pro Asp Gln 
    50                  55                  60


Pro Phe Ile Ala Leu Glu Asp Arg Arg Gly Phe Trp Val Ser Glu Gln 
65                  70                  75                  80


Tyr Gly Arg Leu Arg Pro Gly Leu Ser Glu Lys Ala Ile Ser Ile Trp 
                85                  90                  95


Glu Ser Lys Asn Phe Phe Phe Glu Leu Glu Pro Leu Pro Gly Ala Val 
            100                 105                 110


Glu Ala Val Lys Glu Met Ala Ser Leu Gln Asn Thr Asp Val Phe Ile 
        115                 120                 125


Cys Thr Ser Pro Ile Lys Met Phe Lys Tyr Cys Pro Tyr Glu Lys Tyr 
    130                 135                 140


Ala Trp Val Glu Lys Tyr Phe Gly Pro Asp Phe Leu Glu Gln Ile Val 
145                 150                 155                 160


Leu Thr Arg Asp Lys Thr Val Val Ser Ala Asp Leu Leu Ile Asp Asp 
                165                 170                 175


Arg Pro Asp Ile Thr Gly Ala Glu Pro Thr Pro Ser Trp Glu His Val 
            180                 185                 190


Leu Phe Thr Ala Cys His Asn Gln His Leu Gln Leu Gln Pro Pro Arg 
        195                 200                 205


Arg Arg Leu His Ser Trp Ala Asp Asp Trp Lys Ala Ile Leu Asp Ser 
    210                 215                 220


Lys Arg Pro Cys 
225


<210>  1110
<211>  770
<212>  DNA
<213>  Homo sapiens

<400>  1110
aaaaaaaaaa aaaacaagcc tttccgctcg gctgttttcc tgctcaggag ccgcagggcc     60

gtaggcagcc atgacgccca gccggaatgg catggtcttg aagccccact tccacaagga    120

ctggcagcgg cgcgtggcca cgtggttcaa ccagccggcc cggaagatcc gcagacgtaa    180

ggcccggcaa gccaaggcgc gccgcatcgc cccgcgcccc gcgtcggggc ccatccggcc    240

catcgtgtgc tgccccacgg ttcggtacca cacgaaggtg cgcgccggcc gcggcttcaa    300

tctggaggag ctcagggtgg ccggcattca caagaaggtg gcccggacca tcggcatttc    360

tgtggatccg aggaggcgga acaagtccac ggagtccctg caggcgaacg tgcagcggct    420

gaaggagtac cgctccaaac tcatcctctt ccccaggaag ccctcggccc ccaagaaggg    480

agacagttct gctgaagaac tgaaactggc cacccagctg accggaccgg tcatgcccat    540

ccggaatgtc tataagaagg agaaagctcg agtgatcact gaggaagaga agaatttcaa    600

agccttcgct agtctccgta tggcccgtgc caacgcccgg ctcttcggca tacgggcaaa    660

aagagccaag gaagccgcag aacaggatgt tgaaaagaaa aaataaagcc ctcctgggga    720

cttggaataa aaaaaaaaaa aaaaaaaaaa aaaaaaggag accaaccaaa               770


<210>  1111
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  1111

Met Thr Pro Ser Arg Asn Gly Met Val Leu Lys Pro His Phe His Lys 
1               5                   10                  15


Asp Trp Gln Arg Arg Val Ala Thr Trp Phe Asn Gln Pro Ala Arg Lys 
            20                  25                  30


Ile Arg Arg Arg Lys Ala Arg Gln Ala Lys Ala Arg Arg Ile Ala Pro 
        35                  40                  45


Arg Pro Ala Ser Gly Pro Ile Arg Pro Ile Val Cys Cys Pro Thr Val 
    50                  55                  60


Arg Tyr His Thr Lys Val Arg Ala Gly Arg Gly Phe Asn Leu Glu Glu 
65                  70                  75                  80


Leu Arg Val Ala Gly Ile His Lys Lys Val Ala Arg Thr Ile Gly Ile 
                85                  90                  95


Ser Val Asp Pro Arg Arg Arg Asn Lys Ser Thr Glu Ser Leu Gln Ala 
            100                 105                 110


Asn Val Gln Arg Leu Lys Glu Tyr Arg Ser Lys Leu Ile Leu Phe Pro 
        115                 120                 125


Arg Lys Pro Ser Ala Pro Lys Lys Gly Asp Ser Ser Ala Glu Glu Leu 
    130                 135                 140


Lys Leu Ala Thr Gln Leu Thr Gly Pro Val Met Pro Ile Arg Asn Val 
145                 150                 155                 160


Tyr Lys Lys Glu Lys Ala Arg Val Ile Thr Glu Glu Glu Lys Asn Phe 
                165                 170                 175


Lys Ala Phe Ala Ser Leu Arg Met Ala Arg Ala Asn Ala Arg Leu Phe 
            180                 185                 190


Gly Ile Arg Ala Lys Arg Ala Lys Glu Ala Ala Glu Gln Asp Val Glu 
        195                 200                 205


Lys Lys Lys 
    210


<210>  1112
<211>  1401
<212>  DNA
<213>  Homo sapiens

<400>  1112
atggtgctgc tctttgtcat cgccattggg cctctccagg accctgccca ccacatgcca     60

tgggagatct tactcactcc ccgagcttca gtcatggctg tgtcaatgcc tccctgtcat    120

gggaccctct tttctgaggg aacttctact catcacaaaa ggacctccca tgatggcctg    180

aaaaaagaca ggaagagggg ctcagaagat ggctgatcag acagctgtgt gagcctcaca    240

gccatggcac cctccccaga ggtttctgca gctgccacca cctccttaat gacagacaag    300

cttggcctag acaacctcgc ctgtgtgcct ggcagaggac agtcagccag caatcagccc    360

agggaactct gtctggccag agcaaccaaa ctaggacaca gccctttgag caatccagca    420

actcgtacaa ccacgtagga aagctgtccg gcagcatcgg tcatcacaga acaattagaa    480

gcaaatcttt ccaaaaataa tcgagctttg agtgttcttc gaaggataaa gagtgggagt    540

gtagtcgcca accgagctaa ccagggcaag gaaaattctg aaaacatcac cacccctgaa    600

gtctttccaa ggttgtacca cctgatccca gatggtgaaa ttaccagcat caagatcaat    660

caagtggatc ccagtgaaag cctctccatt atgctgatgg gaggcagtga aaccccactg    720

gtccgtatca tccaacacat ttatcatgat ggggcaaatg ccagagatga ccagctacta    780

ccaggagaca tcatcctaaa tgtcaatggg atggacatta gcaaagtctc tcacaactac    840

gctctgcatc tcctgcggca gccctaccag gtgttgtgac tgaccatgct gcacaaccag    900

aagttctgca gcaggaacag tggacaggcc ctggatgcct acagacccca ggatgacagc    960

tgccatgtga tttgcaacaa aagtagcccc aaggaacagc ttggaataaa attggtgtgc   1020

aaggtggatg agcctggggt gtttatcttc aacgtgctag atggtagtgt ggctgattga   1080

catggtcagc tggaggagaa tgattgtgtg ttagccatca atggacatga ccttcaatat   1140

ggcagcccag aaagcggtgc ttatctgatt caggtattgc tggccctctt caccacttta   1200

aagcaatctc tggcaaggcc attacataag cagtgtccct tgccagctgt caccaaggcc   1260

accggaaaaa tcaagacata tatcctgcaa gacctgggca tgaagccggt gcccacacct   1320

ggcgtgtgga tggccagggg tatttcctcg cagctcttag agccctttgt ctacatcatc   1380

tcacttgcag cctccccatg a                                             1401


<210>  1113
<211>  2222
<212>  DNA
<213>  Homo sapiens

<400>  1113
gtagagtgcg cgacgctttt ggcgacccga cctctggcta acctaccccc ggagccatgg     60

cctctgctgg ggtggcagcc gggcgacagg cggaggatgt attgccgcca acgtccgacc    120

agccgctgcc tgacaccaag ccgctgccgc ctcctcagcc gccgccggtc cctgcgcctc    180

aaccgcagca gtcgccggcg ccacggcctc agtcacctgc ccgcgcgagg gaggaagaga    240

actactcctt tttacctttg gttcacaaca tcatcaaatg catggacaag gacagcccgg    300

aggtccacca ggacctgaac gccctcaaaa gcaagttcca ggagatgcgc aagctcatca    360

gcaccatgcc cggcatccac ctgagccccg aacagcagca gcagcagctg cagagcctcc    420

gggagcaagt caggaccaag aatgagcttc tgcaaaagta caagagcctc tgcatgttcg    480

aaatccccaa ggagtagagt gaggctgact tccttagaaa gagggggaag ccaatggcct    540

gtctccccac taccatcccc aaacgctcct tggggcgtgg ttcctgtgga ccccagctca    600

gctcgtcaag ctgcaggggc ggggctcctg tgctgctgcg cgcgcttcgc ctgtgcggga    660

gccagcgcag agcttggctg cgccgggggt tcctcgtgta gatccatatg tctagatgca    720

taataactgg agtgcctgct ggtggaagtc agaatgctcc tggaggctgc agagggggtg    780

gaggactctc ccctgcctct ggggaggggg ccatctgctg cgcccggccc cactgacaga    840

tctgaagagc acagtaggaa gggaggcggc tcctctttgc ttccttccct ctctctcctc    900

ccacccccat aggatcagtg tgtaccaggt acacattgtt cctgttaaca gcagcttctt    960

gaaacatttg catagaattc actggacgaa ttaagcctgc actcatatgg catagaattg   1020

tgagagaatg ttttgaaagg ccagagggtg gcctttttcc ccaaacagtt tggttccttt   1080

tatgtttgag ccagtgaagg gaactacgct ttgggggctt cagcctagag ccctgccagg   1140

cagcccctgg ctccaggttc cctgcctcct agcgctctcc tcgccttcag ctcttgctcc   1200

cttcctcgtt catcaccctc agtcagtgcc caagagtggc caaaccgctt cacatctgca   1260

gtgcttcccc agggttgaca aggggccgtc ctttccacac aggccagaag aggtcttcag   1320

gcgaaccgac cttccccctt ctggcatttc agattcccct tgctctggtt aaaaggtctt   1380

tccctcgtgg cctttgcact tgcggcagca acgtgtacta cactgcagaa gggttcagta   1440

tgcaccttgt gttgagagag aggcaaccct gggggccagt tcaggtggtc cccaaccata   1500

agctaggtct gaaagttaca cagccaagtt tgagctctta aaagttgatg aacagcctca   1560

tttccccagc ttccctgatt tcttccagat gggacgtttt atttgtgtgc tctcccttga   1620

ctgtcagatt gaagtaagag cagttctctc cgttgcctct cgaggaggag gtgcgaagtc   1680

ctggagtatt gtttgggtct cggaatgggc gcataacctg cgctgaccag tttaggggct   1740

tagcagatgc ctgccagctg acctcgttgg caggagggtt gggtggagat gtttttagca   1800

gagcttccat tagtgtagac ctgtagccac ctgtcagaag gtgggtggca tattggggac   1860

ctgggaatgt gtgaaggagg agatcaaatt tcagtggctt tggacagaaa agaaggctct   1920

ggatttaagc gggtggtcac ctgtgagacc aggtctacct tgggactgtt atttaactga   1980

atcagttatt tccttgaaat ttcacagtag tgggtgggcc tgttttaagg ctctgacaga   2040

taccacgaaa catgaagcac gtggaactac aagacccccg gggtctttct gagtgcaagg   2100

ctgaaatgga caagggctcc tcacgggggt ggagggagcc ggagcctgcc ttgtgttcct   2160

tttttgactt gtgacatttt tcaaacacat aattaaaagg acttatgctc tgctgtctca   2220

gg                                                                  2222


<210>  1114
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  1114

Met Ala Ser Ala Gly Val Ala Ala Gly Arg Gln Ala Glu Asp Val Leu 
1               5                   10                  15


Pro Pro Thr Ser Asp Gln Pro Leu Pro Asp Thr Lys Pro Leu Pro Pro 
            20                  25                  30


Pro Gln Pro Pro Pro Val Pro Ala Pro Gln Pro Gln Gln Ser Pro Ala 
        35                  40                  45


Pro Arg Pro Gln Ser Pro Ala Arg Ala Arg Glu Glu Glu Asn Tyr Ser 
    50                  55                  60


Phe Leu Pro Leu Val His Asn Ile Ile Lys Cys Met Asp Lys Asp Ser 
65                  70                  75                  80


Pro Glu Val His Gln Asp Leu Asn Ala Leu Lys Ser Lys Phe Gln Glu 
                85                  90                  95


Met Arg Lys Leu Ile Ser Thr Met Pro Gly Ile His Leu Ser Pro Glu 
            100                 105                 110


Gln Gln Gln Gln Gln Leu Gln Ser Leu Arg Glu Gln Val Arg Thr Lys 
        115                 120                 125


Asn Glu Leu Leu Gln Lys Tyr Lys Ser Leu Cys Met Phe Glu Ile Pro 
    130                 135                 140


Lys Glu 
145


<210>  1115
<211>  1758
<212>  DNA
<213>  Homo sapiens

<400>  1115
agcaagcggc ctgtgcccag atcctgggag aaccccagcc gagcccagcc tagcccgagc     60

ccagcccgag cggagccgga gccccaagcc cgagccgcgc ccagcccgag cagagccctc    120

cagccgctca ccccgcgtgc caccccagcg accctcagcc gctctctgcc cttctctcgg    180

ccccgcgccc gccctcgcgg cccctctgcc caatgaaact ggccgcgatg atcaagaaga    240

tgtgcccgag cgactcggag ctgagtatcc cggccaagaa ctgctatcgc atggtcatcc    300

tcggctcgtc caaggtgggc aagacggcca tcgtgtcgcg cttcctcacc ggccgcttcg    360

aggacgccta cacgcctacc atcgaggact tccaccgcaa gttctactcc atccgcggcg    420

aggtctacca gctcgacatc ctcgacacgt ccggcaacca cccgttcccc gccatgcggc    480

gcctctccat cctcacagga gacgttttca tcctggtgtt cagtctggac aaccgcgact    540

ccttcgagga ggtgcagcgg ctcaggcagc agatcctcga caccaagtct tgcctcaaga    600

acaaaaccaa ggagaacgtg gacgtgcccc tggtcatctg cggcaacaag ggtgaccgcg    660

acttctaccg cgaggtggac cagcgcgaga tcgagcagct ggtgggcgac gacccccagc    720

gctgcgccta cttcgagatc tcggccaaga agaacagcag cctggaccag atgttccgcg    780

cgctcttcgc catggccaag ctgcccagcg agatgagccc agacctgcac cgcaaggtct    840

cggtgcagta ctgcgacgtg ctgcacaaga aggcgctgcg gaacaagaag ctgctgcggg    900

ccggcagcgg cggcggcggc ggcgacccgg gcgacgcctt tggcatcgtg gcacccttcg    960

cgcgccggcc cagcgtacac agcgacctca tgtacatccg cgagaaggcc agcgccggca   1020

gccaggccaa ggacaaggag cgctgcgtca tcagctagga gccccgccgc gctggcgaca   1080

caacctaagg aggacctttt tgttaagtca aatccaacgg cccggtgcgc cccaggccgg   1140

gagcgcgcgc ggactggcgt ctcccctccc ggcgatccgc ccccagcact ggggaggcgc   1200

cactgaaccg agaagggacg gtcatctgct ccggaaggaa agagaacggg ccaagactgg   1260

gactattccc cacccccggt cccccattga ggcccgccac ccccataact ttgggagcga   1320

gggcccagcc gagggtggat ttatcttctc aaagacctaa gagtgagcgc ggggtggggg   1380

agggatgtga agttatccag cctctgctag gcttcaagaa accgtcatgc ccgcttgagg   1440

gtcaggaccc acggggcatt atcttgtctg tgattccggg ttgctgtgac agccggtaga   1500

gcctctgccc tcccgaaact aagcgggggg gcgtgggtca aatcatagcc aagtgacttg   1560

tttacatgtg agtgaaactg cacaaaggaa cacaaaacaa aacttgcact ttaacggtag   1620

ttccggtgtc aacatggaca cgaacaaaac cttacccagg tgtttatact gtgtgtgtgt   1680

gaggtcttta aagttattgc tttatttggt tttttaatat acaataaaat aatttaaaat   1740

ggaaaaaaaa aaaaaaaa                                                 1758


<210>  1116
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  1116

Met Lys Leu Ala Ala Met Ile Lys Lys Met Cys Pro Ser Asp Ser Glu 
1               5                   10                  15


Leu Ser Ile Pro Ala Lys Asn Cys Tyr Arg Met Val Ile Leu Gly Ser 
            20                  25                  30


Ser Lys Val Gly Lys Thr Ala Ile Val Ser Arg Phe Leu Thr Gly Arg 
        35                  40                  45


Phe Glu Asp Ala Tyr Thr Pro Thr Ile Glu Asp Phe His Arg Lys Phe 
    50                  55                  60


Tyr Ser Ile Arg Gly Glu Val Tyr Gln Leu Asp Ile Leu Asp Thr Ser 
65                  70                  75                  80


Gly Asn His Pro Phe Pro Ala Met Arg Arg Leu Ser Ile Leu Thr Gly 
                85                  90                  95


Asp Val Phe Ile Leu Val Phe Ser Leu Asp Asn Arg Asp Ser Phe Glu 
            100                 105                 110


Glu Val Gln Arg Leu Arg Gln Gln Ile Leu Asp Thr Lys Ser Cys Leu 
        115                 120                 125


Lys Asn Lys Thr Lys Glu Asn Val Asp Val Pro Leu Val Ile Cys Gly 
    130                 135                 140


Asn Lys Gly Asp Arg Asp Phe Tyr Arg Glu Val Asp Gln Arg Glu Ile 
145                 150                 155                 160


Glu Gln Leu Val Gly Asp Asp Pro Gln Arg Cys Ala Tyr Phe Glu Ile 
                165                 170                 175


Ser Ala Lys Lys Asn Ser Ser Leu Asp Gln Met Phe Arg Ala Leu Phe 
            180                 185                 190


Ala Met Ala Lys Leu Pro Ser Glu Met Ser Pro Asp Leu His Arg Lys 
        195                 200                 205


Val Ser Val Gln Tyr Cys Asp Val Leu His Lys Lys Ala Leu Arg Asn 
    210                 215                 220


Lys Lys Leu Leu Arg Ala Gly Ser Gly Gly Gly Gly Gly Asp Pro Gly 
225                 230                 235                 240


Asp Ala Phe Gly Ile Val Ala Pro Phe Ala Arg Arg Pro Ser Val His 
                245                 250                 255


Ser Asp Leu Met Tyr Ile Arg Glu Lys Ala Ser Ala Gly Ser Gln Ala 
            260                 265                 270


Lys Asp Lys Glu Arg Cys Val Ile Ser 
        275                 280


<210>  1117
<211>  1008
<212>  DNA
<213>  Homo sapiens

<400>  1117
ctgaccacag agcgctgctc ccgagaaccc tgcacccctc aatggagtaa attaccataa     60

agcctcttcc ttacccatgc tttggggtgt taacagctga ggctattcgt cggtgacctg    120

tgggactcga gctattcctg cagctcagca gacctcctgg ccgtggcaga cttctgcgtt    180

atgacccggc tgctgggcta cgtggacccc ctggatccca gctttgtggc tgccgtcatc    240

accatcacct tcaatccgct ctactggaat gtggttgcac gatgggaaca caagacccgc    300

aagctgagca gggccttcgg atccccctac ctggcctgct actctctaag cgtcaccatc    360

ctgctcctga acttcctgcg ctcgcactgc ttcacgcagg ccatgctgag ccagcccagg    420

atggagagcc tggacacccc cgcggcctac agcctgggcc tcgcgctcct gggactgggc    480

gtcgtgctcg tgctctccag cttctttgca ctggggttcg ctggaacttt cctaggtgat    540

tacttcggga tcctcaagga ggcgagagtg accgtgttcc ccttcaacat cctggacaac    600

cccatgtact ggggaagcac agccaactac ctgggctggg ccatcatgca cgccagcccc    660

acgggcctgc tcctgacggt gctggtggcc ctcacctaca tagtggctct cctatacgaa    720

gagcccttca ccgctgagat ctaccggcag aaagcctccg ggtcccacaa gaggagctga    780

ttgagctgca acagctttgc tgaaggcctg gccagcctcc tggcctgccc caagtggcag    840

gccctgcgca gggcgagaat ggtgcctgct gctcagggct cgcccccggc gtgggctgcc    900

ccagtgcctt ggaacctgct gccttgggga ccctggacgt gccgacatat ggccattgag    960

ctccaaccca cacattccca ttcaccaata aaggcaccct gaccccaa                1008


<210>  1118
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  1118

Met Thr Arg Leu Leu Gly Tyr Val Asp Pro Leu Asp Pro Ser Phe Val 
1               5                   10                  15


Ala Ala Val Ile Thr Ile Thr Phe Asn Pro Leu Tyr Trp Asn Val Val 
            20                  25                  30


Ala Arg Trp Glu His Lys Thr Arg Lys Leu Ser Arg Ala Phe Gly Ser 
        35                  40                  45


Pro Tyr Leu Ala Cys Tyr Ser Leu Ser Val Thr Ile Leu Leu Leu Asn 
    50                  55                  60


Phe Leu Arg Ser His Cys Phe Thr Gln Ala Met Leu Ser Gln Pro Arg 
65                  70                  75                  80


Met Glu Ser Leu Asp Thr Pro Ala Ala Tyr Ser Leu Gly Leu Ala Leu 
                85                  90                  95


Leu Gly Leu Gly Val Val Leu Val Leu Ser Ser Phe Phe Ala Leu Gly 
            100                 105                 110


Phe Ala Gly Thr Phe Leu Gly Asp Tyr Phe Gly Ile Leu Lys Glu Ala 
        115                 120                 125


Arg Val Thr Val Phe Pro Phe Asn Ile Leu Asp Asn Pro Met Tyr Trp 
    130                 135                 140


Gly Ser Thr Ala Asn Tyr Leu Gly Trp Ala Ile Met His Ala Ser Pro 
145                 150                 155                 160


Thr Gly Leu Leu Leu Thr Val Leu Val Ala Leu Thr Tyr Ile Val Ala 
                165                 170                 175


Leu Leu Tyr Glu Glu Pro Phe Thr Ala Glu Ile Tyr Arg Gln Lys Ala 
            180                 185                 190


Ser Gly Ser His Lys Arg Ser 
        195


<210>  1119
<211>  1028
<212>  DNA
<213>  Homo sapiens

<400>  1119
gggggcgcgt ggctgcagcg gggcccgcgt ggtgcctcct gaggcggccc ccggatgaag     60

agatctggga acccgggagc cgaggtaacg aacagctcgg tggcagggcc tgactgctgc    120

ggaggcctcg gcaatattga ttttagacag gcagacttct gcgttatgac ccggctgctg    180

ggctacgtgg accccctgga tcccagcttt gtggctgccg tcatcaccat caccttcaat    240

ccgctctact ggaatgtggt tgcacgatgg gaacacaaga cccgcaagct gagcagggcc    300

ttcggatccc cctacctggc ctgctactct ctaagcgtca ccatcctgct cctgaacttc    360

ctgcgctcgc actgcttcac gcaggccatg ctgagccagc ccaggatgga gagcctggac    420

acccccgcgg cctacagcct gggcctcgcg ctcctgggac tgggcgtcgt gctcgtgctc    480

tccagcttct ttgcactggg gttcgctgga actttcctag gtgattactt cgggatcctc    540

aaggaggcga gagtgaccgt gttccccttc aacatcctgg acaaccccat gtactgggga    600

agcacagcca actacctggg ctgggccatc atgcacgcca gccccacggg cctgctcctg    660

acggtgctgg tggccctcac ctacatagtg gctctcctat acgaagagcc cttcaccgct    720

gagatctacc ggcagaaagc ctccgggtcc cacaagagga gctgattgag ctgcaacagc    780

tttgctgaag gcctggccag cctcctggcc tgccccaagt ggcaggccct gcgcagggcg    840

agaatggtgc ctgctgctca gggctcgccc ccggcgtggg ctgccccagt gccttggaac    900

ctgctgcctt ggggaccctg gacgtgccga catatggcca ttgagctcca acccacacat    960

tcccattcac caataaaggc accctgaccc caaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1020

aaaaaaaa                                                            1028


<210>  1120
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  1120

Met Lys Arg Ser Gly Asn Pro Gly Ala Glu Val Thr Asn Ser Ser Val 
1               5                   10                  15


Ala Gly Pro Asp Cys Cys Gly Gly Leu Gly Asn Ile Asp Phe Arg Gln 
            20                  25                  30


Ala Asp Phe Cys Val Met Thr Arg Leu Leu Gly Tyr Val Asp Pro Leu 
        35                  40                  45


Asp Pro Ser Phe Val Ala Ala Val Ile Thr Ile Thr Phe Asn Pro Leu 
    50                  55                  60


Tyr Trp Asn Val Val Ala Arg Trp Glu His Lys Thr Arg Lys Leu Ser 
65                  70                  75                  80


Arg Ala Phe Gly Ser Pro Tyr Leu Ala Cys Tyr Ser Leu Ser Val Thr 
                85                  90                  95


Ile Leu Leu Leu Asn Phe Leu Arg Ser His Cys Phe Thr Gln Ala Met 
            100                 105                 110


Leu Ser Gln Pro Arg Met Glu Ser Leu Asp Thr Pro Ala Ala Tyr Ser 
        115                 120                 125


Leu Gly Leu Ala Leu Leu Gly Leu Gly Val Val Leu Val Leu Ser Ser 
    130                 135                 140


Phe Phe Ala Leu Gly Phe Ala Gly Thr Phe Leu Gly Asp Tyr Phe Gly 
145                 150                 155                 160


Ile Leu Lys Glu Ala Arg Val Thr Val Phe Pro Phe Asn Ile Leu Asp 
                165                 170                 175


Asn Pro Met Tyr Trp Gly Ser Thr Ala Asn Tyr Leu Gly Trp Ala Ile 
            180                 185                 190


Met His Ala Ser Pro Thr Gly Leu Leu Leu Thr Val Leu Val Ala Leu 
        195                 200                 205


Thr Tyr Ile Val Ala Leu Leu Tyr Glu Glu Pro Phe Thr Ala Glu Ile 
    210                 215                 220


Tyr Arg Gln Lys Ala Ser Gly Ser His Lys Arg Ser 
225                 230                 235


<210>  1121
<211>  905
<212>  DNA
<213>  Homo sapiens

<400>  1121
ggcgaggaga ggcacaccac tattgtttta atttgctttt acctgattcc tggcagactt     60

ctgcgttatg acccggctgc tgggctacgt ggaccccctg gatcccagct ttgtggctgc    120

cgtcatcacc atcaccttca atccgctcta ctggaatgtg gttgcacgat gggaacacaa    180

gacccgcaag ctgagcaggg ccttcggatc cccctacctg gcctgctact ctctaagcgt    240

caccatcctg ctcctgaact tcctgcgctc gcactgcttc acgcaggcca tgctgagcca    300

gcccaggatg gagagcctgg acacccccgc ggcctacagc ctgggcctcg cgctcctggg    360

actgggcgtc gtgctcgtgc tctccagctt ctttgcactg gggttcgctg gaactttcct    420

aggtgattac ttcgggatcc tcaaggaggc gagagtgacc gtgttcccct tcaacatcct    480

ggacaacccc atgtactggg gaagcacagc caactacctg ggctgggcca tcatgcacgc    540

cagccccacg ggcctgctcc tgacggtgct ggtggccctc acctacatag tggctctcct    600

atacgaagag cccttcaccg ctgagatcta ccggcagaaa gcctccgggt cccacaagag    660

gagctgattg agctgcaaca gctttgctga aggcctggcc agcctcctgg cctgccccaa    720

gtggcaggcc ctgcgcaggg cgagaatggt gcctgctgct cagggctcgc ccccggcgtg    780

ggctgcccca gtgccttgga acctgctgcc ttggggaccc tggacgtgcc gacatatggc    840

cattgagctc caacccacac attcccattc accaataaag gcaccctgac cccaaaaaaa    900

aaaaa                                                                905


<210>  1122
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  1122

Met Thr Arg Leu Leu Gly Tyr Val Asp Pro Leu Asp Pro Ser Phe Val 
1               5                   10                  15


Ala Ala Val Ile Thr Ile Thr Phe Asn Pro Leu Tyr Trp Asn Val Val 
            20                  25                  30


Ala Arg Trp Glu His Lys Thr Arg Lys Leu Ser Arg Ala Phe Gly Ser 
        35                  40                  45


Pro Tyr Leu Ala Cys Tyr Ser Leu Ser Val Thr Ile Leu Leu Leu Asn 
    50                  55                  60


Phe Leu Arg Ser His Cys Phe Thr Gln Ala Met Leu Ser Gln Pro Arg 
65                  70                  75                  80


Met Glu Ser Leu Asp Thr Pro Ala Ala Tyr Ser Leu Gly Leu Ala Leu 
                85                  90                  95


Leu Gly Leu Gly Val Val Leu Val Leu Ser Ser Phe Phe Ala Leu Gly 
            100                 105                 110


Phe Ala Gly Thr Phe Leu Gly Asp Tyr Phe Gly Ile Leu Lys Glu Ala 
        115                 120                 125


Arg Val Thr Val Phe Pro Phe Asn Ile Leu Asp Asn Pro Met Tyr Trp 
    130                 135                 140


Gly Ser Thr Ala Asn Tyr Leu Gly Trp Ala Ile Met His Ala Ser Pro 
145                 150                 155                 160


Thr Gly Leu Leu Leu Thr Val Leu Val Ala Leu Thr Tyr Ile Val Ala 
                165                 170                 175


Leu Leu Tyr Glu Glu Pro Phe Thr Ala Glu Ile Tyr Arg Gln Lys Ala 
            180                 185                 190


Ser Gly Ser His Lys Arg Ser 
        195


<210>  1123
<211>  3948
<212>  DNA
<213>  Homo sapiens

<400>  1123
agaagcagaa aaggttggat aaaagataag gacagaccca cgaagtcaag catgcggagt     60

gcagccaagc cctggaaccc agccatcaga gcagggggcc acggcccaga ccgggtgcgg    120

cctctgcctg cagcctcttc cggcatgaag agttctaagt cttcaacttc cttggctttt    180

gagtcccgac tcagcaggct caagagggcc agcagtgagg acacgctcaa caagccagga    240

agtaccgctg catcgggggt ggttcgcctg aagaagaccg ccactgccgg agccatctcg    300

gagctcacgg agagccgcct gaggagcggc acaggggcct ttacaacaac taaacggaca    360

ggcattccag ccccacggga attttcagta actgtctcaa gagagaggtc tgtgccacgt    420

ggtccctcca accccaggaa atcagtgtcc agtccaactt cttccaacac tcccactcct    480

acgaaacacc tgaggacccc ttccacaaag cccaagcaag agaatgaagg tggagaaaag    540

gctgcgcttg agtcccaagt tcgggaactt ttggcagaag ccaaagcaaa agatagtgaa    600

attaacaggc ttcgaagtga actaaagaaa tacaaagaga aaaggactct gaacgctgag    660

gggactgatg ctttgggccc aaatgtcgat ggaacatcag tctccccagg tgacacggaa    720

cctatgataa gagctcttga ggagaagaac aagaactttc agaaagagct ttccgatcta    780

gaggaagaaa accgggtcct gaaggagaaa ctgatctatc ttgagcactc cccaaattca    840

gaaggggcag caagtcacac tggcgacagc agctgcccaa catccataac tcaagagtca    900

agcttcggaa gcccaactgg aaatcagatg tccagtgaca ttgatgagta taaaaaaaac    960

atacatggaa atgcattacg gacatcaggc tcctcaagta gcgatgttac caaagcttct   1020

ttgtcgccag atgcttccga ctttgagcac attacagcag agacaccctc aaggcccctg   1080

tcctccacca gtaacccctt taagagttca aagtgttcta ctgctgggag ttccccaaac   1140

agcgtaagtg aattgtccct ggcttccctc acagagaaga tacaaaagat ggaagaaaac   1200

caccatagca ctgcagaaga actacaggct actctacaag aattatcaga ccagcaacaa   1260

atggtacagg aattgacagc tgaaaatgag aagctggtgg atgaaaagac gattttagag   1320

acatcctttc atcagcatcg agagagggca gagcagctaa gtcaagaaaa tgagaagctg   1380

atgaatcttt tacaagagcg agtaaagaat gaagagccca ccactcagga aggaaaaatt   1440

attgaactgg agcagaagtg cacaggtatt cttgaacagg gccgctttga aagagagaag   1500

ctactcaaca ttcagcagca gttgacctgt agcttgcgga aggttgagga agaaaaccaa   1560

ggagctttag aaatgattaa acgtctgaag gaagaaaatg aaaaactgaa tgagtttcta   1620

gaactggaac ggcataataa taacatgatg gccaaaactt tggaagagtg tagagttacc   1680

ttggaagggc taaaaatgga gaatggatct ttgaagtctc atttgcaggg tgagaagcag   1740

aaagccacag aggccagtgc tgtggagcag acggcagaga gctgcgaagt tcaagaaatg   1800

ttgaaagtag cccgagcaga gaaagatcta ctggaactgt cttgcaatga gctcagacaa   1860

gaattactaa aggcaaacgg tgaaattaaa catgtttcca gtctgctggc caaggtggaa   1920

aaggattatt catacctgaa ggagatatgt gatcaccaag ccgaacagct gagcagaacc   1980

agcctaaagc tgcaagaaaa agcatcagag agtgatgcag agatcaaaga catgaaagaa   2040

accatatttg aattggaaga tcaggtggaa cagcaccggg ctgtcaagtt acacaataat   2100

caactcatca gtgagctaga aagtagtgtg atcaagctgg aggaacagaa gtcagacctg   2160

gagaggcagc tgaagactct gaccaagcag atgaaggagg agaccgagga atggaggcgg   2220

ttccaggcgg atctgcagac cgcagtggtg gtggccaatg acatcaagtg tgaggcccag   2280

caggagctgc gcaccgtgaa gaggaaactg ctggaggagg aggagaagaa tgcccggttg   2340

cagaaggagc tgggggatgt gcagggccac ggcagggtgg tcaccagcag agccgcccct   2400

ccacctgtgg atgaagagcc agagtcctct gaggtcgatg ctgctggtcg gtggcctggt   2460

gtctgtgtta gcagaacatc tccaacaccc ccagagtcgg caaccaccgt taagtcactt   2520

atcaagtcat ttgacttggg acgcccaggt ggagctggac agaatatttc tgtccataag   2580

acccccagaa gtcccctaag tgggatacca gtgaggactg ctccagcagc tgctgtctct   2640

ccaatgcaga ggcattcgac ttacagcagt gtgcggccag ccagcagagg ggtgactcaa   2700

cgcttggacc ttcctgacct tcccctctca gatattctaa agggaaggac tgagaccctg   2760

aagccagacc cccacctccg caagagtccc tcactagagt cactgagcag acccccgtct   2820

ctgggctttg gggacacaag actgctgagt gcttccaccc gggcatggaa accacaaagc   2880

aaactcagtg tggaaagaaa agaccctctg gcagccttgg cccgggaata cggtggttcc   2940

aagcgcaatg ctctactgaa atggtgccag aagaagacac aaggttatgc gaacattgac   3000

atcaccaatt tcagcagcag ctggagcgat ggcctggcct tctgtgctct gctccacacc   3060

tacctgcctg cccacatccc ctaccaggag ctgaatagtc aggagaaaaa gaggaatctc   3120

ttgttggcat ttgaagcggc tgaaagtgta ggcatcaaac ccagcctgga actcagcgag   3180

atgctgtaca cagaccggcc cgactggcag agtgtgatgc agtacgtggc ccaaatctac   3240

aagtactttg agacgtaacc ctggagggcc tggggcagcc accattgcca cctactgcag   3300

cttttcctgg aagcgcctga ttactgtcca ctgaccctgc tctgcccacc acccagctgc   3360

ctagacttca aagacaggct caatccaagt ggaccaacac ccaaataaga aacagagtgg   3420

gtcccacgat gtacctgtct gaaatgcaaa tgcagctgga ctgtaaattg gggactcttt   3480

gatctcttgt gggatgcttc taaagagggc agcctccctc cttccagacc aagaccccac   3540

acccaggctt gttttgctga ttatattggg tggctgaacg aacacattat ctgcagaaat   3600

tcagacaaag aacatctcca aatcagtctt ttggttgctg ttgttaaaaa tatcccggct   3660

ttgcctttat gaaacctttg cccttggctg ggtgtggtag ctcgtggctg taatcccagc   3720

actttaggaa gccaaggcag taggatcgtt tgagcccagg agttcgaggc tgcagtgagc   3780

tatgagcata ccactgcact ccagcctgtg tgaaagagcc agaccctgtc tcaaaaaaat   3840

gataaaaccc aaaactttgc ccttgtgaac cctcccttcc cccctccccc cccaaaaaaa   3900

aacaacaaaa cacaaaaaat aaacatttgt tccagggcaa cctggaaa                3948


<210>  1124
<211>  1068
<212>  PRT
<213>  Homo sapiens

<400>  1124

Met Arg Ser Ala Ala Lys Pro Trp Asn Pro Ala Ile Arg Ala Gly Gly 
1               5                   10                  15


His Gly Pro Asp Arg Val Arg Pro Leu Pro Ala Ala Ser Ser Gly Met 
            20                  25                  30


Lys Ser Ser Lys Ser Ser Thr Ser Leu Ala Phe Glu Ser Arg Leu Ser 
        35                  40                  45


Arg Leu Lys Arg Ala Ser Ser Glu Asp Thr Leu Asn Lys Pro Gly Ser 
    50                  55                  60


Thr Ala Ala Ser Gly Val Val Arg Leu Lys Lys Thr Ala Thr Ala Gly 
65                  70                  75                  80


Ala Ile Ser Glu Leu Thr Glu Ser Arg Leu Arg Ser Gly Thr Gly Ala 
                85                  90                  95


Phe Thr Thr Thr Lys Arg Thr Gly Ile Pro Ala Pro Arg Glu Phe Ser 
            100                 105                 110


Val Thr Val Ser Arg Glu Arg Ser Val Pro Arg Gly Pro Ser Asn Pro 
        115                 120                 125


Arg Lys Ser Val Ser Ser Pro Thr Ser Ser Asn Thr Pro Thr Pro Thr 
    130                 135                 140


Lys His Leu Arg Thr Pro Ser Thr Lys Pro Lys Gln Glu Asn Glu Gly 
145                 150                 155                 160


Gly Glu Lys Ala Ala Leu Glu Ser Gln Val Arg Glu Leu Leu Ala Glu 
                165                 170                 175


Ala Lys Ala Lys Asp Ser Glu Ile Asn Arg Leu Arg Ser Glu Leu Lys 
            180                 185                 190


Lys Tyr Lys Glu Lys Arg Thr Leu Asn Ala Glu Gly Thr Asp Ala Leu 
        195                 200                 205


Gly Pro Asn Val Asp Gly Thr Ser Val Ser Pro Gly Asp Thr Glu Pro 
    210                 215                 220


Met Ile Arg Ala Leu Glu Glu Lys Asn Lys Asn Phe Gln Lys Glu Leu 
225                 230                 235                 240


Ser Asp Leu Glu Glu Glu Asn Arg Val Leu Lys Glu Lys Leu Ile Tyr 
                245                 250                 255


Leu Glu His Ser Pro Asn Ser Glu Gly Ala Ala Ser His Thr Gly Asp 
            260                 265                 270


Ser Ser Cys Pro Thr Ser Ile Thr Gln Glu Ser Ser Phe Gly Ser Pro 
        275                 280                 285


Thr Gly Asn Gln Met Ser Ser Asp Ile Asp Glu Tyr Lys Lys Asn Ile 
    290                 295                 300


His Gly Asn Ala Leu Arg Thr Ser Gly Ser Ser Ser Ser Asp Val Thr 
305                 310                 315                 320


Lys Ala Ser Leu Ser Pro Asp Ala Ser Asp Phe Glu His Ile Thr Ala 
                325                 330                 335


Glu Thr Pro Ser Arg Pro Leu Ser Ser Thr Ser Asn Pro Phe Lys Ser 
            340                 345                 350


Ser Lys Cys Ser Thr Ala Gly Ser Ser Pro Asn Ser Val Ser Glu Leu 
        355                 360                 365


Ser Leu Ala Ser Leu Thr Glu Lys Ile Gln Lys Met Glu Glu Asn His 
    370                 375                 380


His Ser Thr Ala Glu Glu Leu Gln Ala Thr Leu Gln Glu Leu Ser Asp 
385                 390                 395                 400


Gln Gln Gln Met Val Gln Glu Leu Thr Ala Glu Asn Glu Lys Leu Val 
                405                 410                 415


Asp Glu Lys Thr Ile Leu Glu Thr Ser Phe His Gln His Arg Glu Arg 
            420                 425                 430


Ala Glu Gln Leu Ser Gln Glu Asn Glu Lys Leu Met Asn Leu Leu Gln 
        435                 440                 445


Glu Arg Val Lys Asn Glu Glu Pro Thr Thr Gln Glu Gly Lys Ile Ile 
    450                 455                 460


Glu Leu Glu Gln Lys Cys Thr Gly Ile Leu Glu Gln Gly Arg Phe Glu 
465                 470                 475                 480


Arg Glu Lys Leu Leu Asn Ile Gln Gln Gln Leu Thr Cys Ser Leu Arg 
                485                 490                 495


Lys Val Glu Glu Glu Asn Gln Gly Ala Leu Glu Met Ile Lys Arg Leu 
            500                 505                 510


Lys Glu Glu Asn Glu Lys Leu Asn Glu Phe Leu Glu Leu Glu Arg His 
        515                 520                 525


Asn Asn Asn Met Met Ala Lys Thr Leu Glu Glu Cys Arg Val Thr Leu 
    530                 535                 540


Glu Gly Leu Lys Met Glu Asn Gly Ser Leu Lys Ser His Leu Gln Gly 
545                 550                 555                 560


Glu Lys Gln Lys Ala Thr Glu Ala Ser Ala Val Glu Gln Thr Ala Glu 
                565                 570                 575


Ser Cys Glu Val Gln Glu Met Leu Lys Val Ala Arg Ala Glu Lys Asp 
            580                 585                 590


Leu Leu Glu Leu Ser Cys Asn Glu Leu Arg Gln Glu Leu Leu Lys Ala 
        595                 600                 605


Asn Gly Glu Ile Lys His Val Ser Ser Leu Leu Ala Lys Val Glu Lys 
    610                 615                 620


Asp Tyr Ser Tyr Leu Lys Glu Ile Cys Asp His Gln Ala Glu Gln Leu 
625                 630                 635                 640


Ser Arg Thr Ser Leu Lys Leu Gln Glu Lys Ala Ser Glu Ser Asp Ala 
                645                 650                 655


Glu Ile Lys Asp Met Lys Glu Thr Ile Phe Glu Leu Glu Asp Gln Val 
            660                 665                 670


Glu Gln His Arg Ala Val Lys Leu His Asn Asn Gln Leu Ile Ser Glu 
        675                 680                 685


Leu Glu Ser Ser Val Ile Lys Leu Glu Glu Gln Lys Ser Asp Leu Glu 
    690                 695                 700


Arg Gln Leu Lys Thr Leu Thr Lys Gln Met Lys Glu Glu Thr Glu Glu 
705                 710                 715                 720


Trp Arg Arg Phe Gln Ala Asp Leu Gln Thr Ala Val Val Val Ala Asn 
                725                 730                 735


Asp Ile Lys Cys Glu Ala Gln Gln Glu Leu Arg Thr Val Lys Arg Lys 
            740                 745                 750


Leu Leu Glu Glu Glu Glu Lys Asn Ala Arg Leu Gln Lys Glu Leu Gly 
        755                 760                 765


Asp Val Gln Gly His Gly Arg Val Val Thr Ser Arg Ala Ala Pro Pro 
    770                 775                 780


Pro Val Asp Glu Glu Pro Glu Ser Ser Glu Val Asp Ala Ala Gly Arg 
785                 790                 795                 800


Trp Pro Gly Val Cys Val Ser Arg Thr Ser Pro Thr Pro Pro Glu Ser 
                805                 810                 815


Ala Thr Thr Val Lys Ser Leu Ile Lys Ser Phe Asp Leu Gly Arg Pro 
            820                 825                 830


Gly Gly Ala Gly Gln Asn Ile Ser Val His Lys Thr Pro Arg Ser Pro 
        835                 840                 845


Leu Ser Gly Ile Pro Val Arg Thr Ala Pro Ala Ala Ala Val Ser Pro 
    850                 855                 860


Met Gln Arg His Ser Thr Tyr Ser Ser Val Arg Pro Ala Ser Arg Gly 
865                 870                 875                 880


Val Thr Gln Arg Leu Asp Leu Pro Asp Leu Pro Leu Ser Asp Ile Leu 
                885                 890                 895


Lys Gly Arg Thr Glu Thr Leu Lys Pro Asp Pro His Leu Arg Lys Ser 
            900                 905                 910


Pro Ser Leu Glu Ser Leu Ser Arg Pro Pro Ser Leu Gly Phe Gly Asp 
        915                 920                 925


Thr Arg Leu Leu Ser Ala Ser Thr Arg Ala Trp Lys Pro Gln Ser Lys 
    930                 935                 940


Leu Ser Val Glu Arg Lys Asp Pro Leu Ala Ala Leu Ala Arg Glu Tyr 
945                 950                 955                 960


Gly Gly Ser Lys Arg Asn Ala Leu Leu Lys Trp Cys Gln Lys Lys Thr 
                965                 970                 975


Gln Gly Tyr Ala Asn Ile Asp Ile Thr Asn Phe Ser Ser Ser Trp Ser 
            980                 985                 990


Asp Gly Leu Ala Phe Cys Ala Leu Leu His Thr Tyr Leu Pro Ala His 
        995                 1000                1005


Ile Pro Tyr Gln Glu Leu Asn Ser Gln Glu Lys Lys Arg Asn Leu Leu 
    1010                1015                1020


Leu Ala Phe Glu Ala Ala Glu Ser Val Gly Ile Lys Pro Ser Leu Glu 
1025                1030                1035                1040


Leu Ser Glu Met Leu Tyr Thr Asp Arg Pro Asp Trp Gln Ser Val Met 
                1045                1050                1055


Gln Tyr Val Ala Gln Ile Tyr Lys Tyr Phe Glu Thr 
            1060                1065


<210>  1125
<211>  2536
<212>  DNA
<213>  Homo sapiens

<400>  1125
cggacccgcc ggacgcaacc gcctcgccag ccggagccag cgcgagctcg gcacggtgga     60

cacccggtcc gaggccggca agccggctgg tgcccgagtc ggccaagcat gggcaaccac    120

tcaggacggc ccgaggatcc ggaaccaggg gcctttacaa caactaaacg gacaggcatt    180

ccagccccac gggaattttc agtaactgtc tcaagagaga ggtctgtgcc acgtggtccc    240

tccaacccca ggaaatcagt gtccagtcca acttcttcca acactcccac tcctacgaaa    300

cacctgagga ccccttccac aaagcccaag caagagaatg aaggtggaga aaaggctgcg    360

cttgagtccc aagttcggga acttttggca gaagccaaag caaaagatag tgaaattaac    420

aggcttcgaa gtgaactaaa gaaatacaaa gagaaaagga ctctgaacgc tgaggggact    480

gatgctttgg gcccaaatgt cgatggaaca tcagtctccc caggtgacac ggaacctatg    540

ataagagctc ttgaggagaa gaacaagaac tttcagaaag agctttccga tctagaggaa    600

gaaaaccggg tcctgaagga gaaactgatc tatcttgagc actccccaaa ttcagaaggg    660

gcagcaagtc acactggcga cagcagctgc ccaacatcca taactcaaga gtcaagcttc    720

ggaagcccaa ctggaaatca gatgtccagt gacattgatg agtataaaaa aaacatacat    780

ggaaatgcat tacggacatc aggctcctca agtagcgatg ttaccaaagc ttctttgtcg    840

ccagatgctt ccgactttga gcacattaca gcagagacac cctcaaggcc cctgtcctcc    900

accagtaacc cctttaagag ttcaaagtgt tctactgctg ggagttcccc aaacagcgta    960

agtgaattgt ccctggcttc cctcacagag aagatacaaa agatggaaga aaaccaccat   1020

agcactgcag aagaactaca ggctactcta caagaattat cagaccagca acaaatggta   1080

caggaattga cagctgaaaa tgagaagctg gtggatgaaa agacgatttt agagacatcc   1140

tttcatcagc atcgagagag ggcagagcag ctaagtcaag aaaatgagaa gctgatgaat   1200

cttttacaag agcgagtaaa gaatgaagag cccaccactc aggaaggaaa aattattgaa   1260

ctggagcaga agtgcacagg tattcttgaa cagggccgct ttgaaagaga gaagctactc   1320

aacattcagc agcagttgac ctgtagcttg cggaaggttg aggaagaaaa ccaaggagct   1380

ttagaaatga ttaaacgtct gaaggaagaa aatgaaaaac tgaatgagtt tctagaactg   1440

gaacggcata ataataacat gatggccaaa actttggaag agtgtagagt taccttggaa   1500

gggctaaaaa tggagaatgg atctttgaag tctcatttgc agggtgagaa gcagaaagcc   1560

acagaggcca gtgctgtgga gcagacggca gagagctgcg aagttcaaga aatgttgaaa   1620

gtagcccgag cagagaaaga tctactggaa ctgtcttgca atgagctcag acaagaatta   1680

ctaaaggcaa acggtgaaat taaacatgtt tccagtctgc tggccaaggt ggaaaaggat   1740

tattcatacc tgaaggagat atgtgatcac caagccgaac agctgagcag aaccagccta   1800

aagctgcaag aaaaagcatc agagagtgat gcagagatca aagacatgaa agaaaccata   1860

tttgaattgg aagatcaggt ggaacagcac cgggctgtca agttacacaa taatcaactc   1920

atcagtgagc tagaaagtag tgtgatcaag ctggaggaac agaagtcaga cctggagagg   1980

cagctgaaga ctctgaccaa gcagatgaag gaggagaccg aggaatggag gcggttccag   2040

gcggatctgc agaccgcagt ggtggtggcc aatgacatca agtgtgaggc ccagcaggag   2100

ctgcgcaccg tgaagaggaa actgctggag gaggaggaga agaatgcccg gttgcagaag   2160

gagctggggg atgtgcaggg ccacggcagg gtggtcacca gcagagccgc ccctccctcc   2220

ctgggctctg tcagctagca gagcatttgg tggaagaaag acagcccagc tcttgccatg   2280

attgggagcc gcagccatct ctagatgaaa gggggaatgt gtagaggaga aattgcctct   2340

ttataaagag cccagttgtc tccttgtgac attctctgtt tctcagagtc attgccgtcg   2400

agtctctgct ttttgtccac attttgggat cagcttactg catgatcaaa gatgatgttt   2460

ccctcttttt acttttcctc agaagattga gctgtctttt atttggagaa taaaatgaag   2520

ttctgaaaaa aacaaa                                                   2536


<210>  1126
<211>  709
<212>  PRT
<213>  Homo sapiens

<400>  1126

Met Gly Asn His Ser Gly Arg Pro Glu Asp Pro Glu Pro Gly Ala Phe 
1               5                   10                  15


Thr Thr Thr Lys Arg Thr Gly Ile Pro Ala Pro Arg Glu Phe Ser Val 
            20                  25                  30


Thr Val Ser Arg Glu Arg Ser Val Pro Arg Gly Pro Ser Asn Pro Arg 
        35                  40                  45


Lys Ser Val Ser Ser Pro Thr Ser Ser Asn Thr Pro Thr Pro Thr Lys 
    50                  55                  60


His Leu Arg Thr Pro Ser Thr Lys Pro Lys Gln Glu Asn Glu Gly Gly 
65                  70                  75                  80


Glu Lys Ala Ala Leu Glu Ser Gln Val Arg Glu Leu Leu Ala Glu Ala 
                85                  90                  95


Lys Ala Lys Asp Ser Glu Ile Asn Arg Leu Arg Ser Glu Leu Lys Lys 
            100                 105                 110


Tyr Lys Glu Lys Arg Thr Leu Asn Ala Glu Gly Thr Asp Ala Leu Gly 
        115                 120                 125


Pro Asn Val Asp Gly Thr Ser Val Ser Pro Gly Asp Thr Glu Pro Met 
    130                 135                 140


Ile Arg Ala Leu Glu Glu Lys Asn Lys Asn Phe Gln Lys Glu Leu Ser 
145                 150                 155                 160


Asp Leu Glu Glu Glu Asn Arg Val Leu Lys Glu Lys Leu Ile Tyr Leu 
                165                 170                 175


Glu His Ser Pro Asn Ser Glu Gly Ala Ala Ser His Thr Gly Asp Ser 
            180                 185                 190


Ser Cys Pro Thr Ser Ile Thr Gln Glu Ser Ser Phe Gly Ser Pro Thr 
        195                 200                 205


Gly Asn Gln Met Ser Ser Asp Ile Asp Glu Tyr Lys Lys Asn Ile His 
    210                 215                 220


Gly Asn Ala Leu Arg Thr Ser Gly Ser Ser Ser Ser Asp Val Thr Lys 
225                 230                 235                 240


Ala Ser Leu Ser Pro Asp Ala Ser Asp Phe Glu His Ile Thr Ala Glu 
                245                 250                 255


Thr Pro Ser Arg Pro Leu Ser Ser Thr Ser Asn Pro Phe Lys Ser Ser 
            260                 265                 270


Lys Cys Ser Thr Ala Gly Ser Ser Pro Asn Ser Val Ser Glu Leu Ser 
        275                 280                 285


Leu Ala Ser Leu Thr Glu Lys Ile Gln Lys Met Glu Glu Asn His His 
    290                 295                 300


Ser Thr Ala Glu Glu Leu Gln Ala Thr Leu Gln Glu Leu Ser Asp Gln 
305                 310                 315                 320


Gln Gln Met Val Gln Glu Leu Thr Ala Glu Asn Glu Lys Leu Val Asp 
                325                 330                 335


Glu Lys Thr Ile Leu Glu Thr Ser Phe His Gln His Arg Glu Arg Ala 
            340                 345                 350


Glu Gln Leu Ser Gln Glu Asn Glu Lys Leu Met Asn Leu Leu Gln Glu 
        355                 360                 365


Arg Val Lys Asn Glu Glu Pro Thr Thr Gln Glu Gly Lys Ile Ile Glu 
    370                 375                 380


Leu Glu Gln Lys Cys Thr Gly Ile Leu Glu Gln Gly Arg Phe Glu Arg 
385                 390                 395                 400


Glu Lys Leu Leu Asn Ile Gln Gln Gln Leu Thr Cys Ser Leu Arg Lys 
                405                 410                 415


Val Glu Glu Glu Asn Gln Gly Ala Leu Glu Met Ile Lys Arg Leu Lys 
            420                 425                 430


Glu Glu Asn Glu Lys Leu Asn Glu Phe Leu Glu Leu Glu Arg His Asn 
        435                 440                 445


Asn Asn Met Met Ala Lys Thr Leu Glu Glu Cys Arg Val Thr Leu Glu 
    450                 455                 460


Gly Leu Lys Met Glu Asn Gly Ser Leu Lys Ser His Leu Gln Gly Glu 
465                 470                 475                 480


Lys Gln Lys Ala Thr Glu Ala Ser Ala Val Glu Gln Thr Ala Glu Ser 
                485                 490                 495


Cys Glu Val Gln Glu Met Leu Lys Val Ala Arg Ala Glu Lys Asp Leu 
            500                 505                 510


Leu Glu Leu Ser Cys Asn Glu Leu Arg Gln Glu Leu Leu Lys Ala Asn 
        515                 520                 525


Gly Glu Ile Lys His Val Ser Ser Leu Leu Ala Lys Val Glu Lys Asp 
    530                 535                 540


Tyr Ser Tyr Leu Lys Glu Ile Cys Asp His Gln Ala Glu Gln Leu Ser 
545                 550                 555                 560


Arg Thr Ser Leu Lys Leu Gln Glu Lys Ala Ser Glu Ser Asp Ala Glu 
                565                 570                 575


Ile Lys Asp Met Lys Glu Thr Ile Phe Glu Leu Glu Asp Gln Val Glu 
            580                 585                 590


Gln His Arg Ala Val Lys Leu His Asn Asn Gln Leu Ile Ser Glu Leu 
        595                 600                 605


Glu Ser Ser Val Ile Lys Leu Glu Glu Gln Lys Ser Asp Leu Glu Arg 
    610                 615                 620


Gln Leu Lys Thr Leu Thr Lys Gln Met Lys Glu Glu Thr Glu Glu Trp 
625                 630                 635                 640


Arg Arg Phe Gln Ala Asp Leu Gln Thr Ala Val Val Val Ala Asn Asp 
                645                 650                 655


Ile Lys Cys Glu Ala Gln Gln Glu Leu Arg Thr Val Lys Arg Lys Leu 
            660                 665                 670


Leu Glu Glu Glu Glu Lys Asn Ala Arg Leu Gln Lys Glu Leu Gly Asp 
        675                 680                 685


Val Gln Gly His Gly Arg Val Val Thr Ser Arg Ala Ala Pro Pro Ser 
    690                 695                 700


Leu Gly Ser Val Ser 
705


<210>  1127
<211>  3762
<212>  DNA
<213>  Homo sapiens

<400>  1127
cggacccgcc ggacgcaacc gcctcgccag ccggagccag cgcgagctcg gcacggtgga     60

cacccggtcc gaggccggca agccggctgg tgcccgagtc ggccaagcat gggcaaccac    120

tcaggacggc ccgaggatcc ggaaccaggg gcctttacaa caactaaacg gacaggcatt    180

ccagccccac gggaattttc agtaactgtc tcaagagaga ggtctgtgcc acgtggtccc    240

tccaacccca ggaaatcagt gtccagtcca acttcttcca acactcccac tcctacgaaa    300

cacctgagga ccccttccac aaagcccaag caagagaatg aaggtggaga aaaggctgcg    360

cttgagtccc aagttcggga acttttggca gaagccaaag caaaagatag tgaaattaac    420

aggcttcgaa gtgaactaaa gaaatacaaa gagaaaagga ctctgaacgc tgaggggact    480

gatgctttgg gcccaaatgt cgatggaaca tcagtctccc caggtgacac ggaacctatg    540

ataagagctc ttgaggagaa gaacaagaac tttcagaaag agctttccga tctagaggaa    600

gaaaaccggg tcctgaagga gaaactgatc tatcttgagc actccccaaa ttcagaaggg    660

gcagcaagtc acactggcga cagcagctgc ccaacatcca taactcaaga gtcaagcttc    720

ggaagcccaa ctggaaatca gatgtccagt gacattgatg agtataaaaa aaacatacat    780

ggaaatgcat tacggacatc aggctcctca agtagcgatg ttaccaaagc ttctttgtcg    840

ccagatgctt ccgactttga gcacattaca gcagagacac cctcaaggcc cctgtcctcc    900

accagtaacc cctttaagag ttcaaagtgt tctactgctg ggagttcccc aaacagcgta    960

agtgaattgt ccctggcttc cctcacagag aagatacaaa agatggaaga aaaccaccat   1020

agcactgcag aagaactaca ggctactcta caagaattat cagaccagca acaaatggta   1080

caggaattga cagctgaaaa tgagaagctg gtggatgaaa agacgatttt agagacatcc   1140

tttcatcagc atcgagagag ggcagagcag ctaagtcaag aaaatgagaa gctgatgaat   1200

cttttacaag agcgagtaaa gaatgaagag cccaccactc aggaaggaaa aattattgaa   1260

ctggagcaga agtgcacagg tattcttgaa cagggccgct ttgaaagaga gaagctactc   1320

aacattcagc agcagttgac ctgtagcttg cggaaggttg aggaagaaaa ccaaggagct   1380

ttagaaatga ttaaacgtct gaaggaagaa aatgaaaaac tgaatgagtt tctagaactg   1440

gaacggcata ataataacat gatggccaaa actttggaag agtgtagagt taccttggaa   1500

gggctaaaaa tggagaatgg atctttgaag tctcatttgc agggtgagaa gcagaaagcc   1560

acagaggcca gtgctgtgga gcagacggca gagagctgcg aagttcaaga aatgttgaaa   1620

gtagcccgag cagagaaaga tctactggaa ctgtcttgca atgagctcag acaagaatta   1680

ctaaaggcaa acggtgaaat taaacatgtt tccagtctgc tggccaaggt ggaaaaggat   1740

tattcatacc tgaaggagat atgtgatcac caagccgaac agctgagcag aaccagccta   1800

aagctgcaag aaaaagcatc agagagtgat gcagagatca aagacatgaa agaaaccata   1860

tttgaattgg aagatcaggt ggaacagcac cgggctgtca agttacacaa taatcaactc   1920

atcagtgagc tagaaagtag tgtgatcaag ctggaggaac agaagtcaga cctggagagg   1980

cagctgaaga ctctgaccaa gcagatgaag gaggagaccg aggaatggag gcggttccag   2040

gcggatctgc agaccgcagt ggtggtggcc aatgacatca agtgtgaggc ccagcaggag   2100

ctgcgcaccg tgaagaggaa actgctggag gaggaggaga agaatgcccg gttgcagaag   2160

gagctggggg atgtgcaggg ccacggcagg gtggtcacca gcagagccgc ccctccacct   2220

gtggatgaag agccagagtc ctctgaggtc gatgctgctg gtcggtggcc tggtgtctgt   2280

gttagcagaa catctccaac acccccagag tcggcaacca ccgttaagtc acttatcaag   2340

tcatttgact tgggacgccc aggtggagct ggacagaata tttctgtcca taagaccccc   2400

agaagtcccc taagtgggat accagtgagg actgctccag cagctgctgt ctctccaatg   2460

cagaggcatt cgacttacag cagtgtgcgg ccagccagca gaggggtgac tcaacgcttg   2520

gaccttcctg accttcccct ctcagatatt ctaaagggaa ggactgagac cctgaagcca   2580

gacccccacc tccgcaagag tccctcacta gagtcactga gcagaccccc gtctctgggc   2640

tttggggaca caagactgct gagtgcttcc acccgggcat ggaaaccaca aagcaaactc   2700

agtgtggaaa gaaaagaccc tctggcagcc ttggcccggg aatacggtgg ttccaagcgc   2760

aatgctctac tgaaatggtg ccagaagaag acacaaggtt atgcgaacat tgacatcacc   2820

aatttcagca gcagctggag cgatggcctg gccttctgtg ctctgctcca cacctacctg   2880

cctgcccaca tcccctacca ggagctgaat agtcaggaga aaaagaggaa tctcttgttg   2940

gcatttgaag cggctgaaag tgtaggcatc aaacccagcc tggaactcag cgagatgctg   3000

tacacagacc ggcccgactg gcagagtgtg atgcagtacg tggcccaaat ctacaagtac   3060

tttgagacgt aaccctggag ggcctggggc agccaccatt gccacctact gcagcttttc   3120

ctggaagcgc ctgattactg tccactgacc ctgctctgcc caccacccag ctgcctagac   3180

ttcaaagaca ggctcaatcc aagtggacca acacccaaat aagaaacaga gtgggtccca   3240

cgatgtacct gtctgaaatg caaatgcagc tggactgtaa attggggact ctttgatctc   3300

ttgtgggatg cttctaaaga gggcagcctc cctccttcca gaccaagacc ccacacccag   3360

gcttgttttg ctgattatat tgggtggctg aacgaacaca ttatctgcag aaattcagac   3420

aaagaacatc tccaaatcag tcttttggtt gctgttgtta aaaatatccc ggctttgcct   3480

ttatgaaacc tttgcccttg gctgggtgtg gtagctcgtg gctgtaatcc cagcacttta   3540

ggaagccaag gcagtaggat cgtttgagcc caggagttcg aggctgcagt gagctatgag   3600

cataccactg cactccagcc tgtgtgaaag agccagaccc tgtctcaaaa aaatgataaa   3660

acccaaaact ttgcccttgt gaaccctccc ttcccccctc cccccccaaa aaaaaacaac   3720

aaaacacaaa aaataaacat ttgttccagg gcaacctgga aa                      3762


<210>  1128
<211>  987
<212>  PRT
<213>  Homo sapiens

<400>  1128

Met Gly Asn His Ser Gly Arg Pro Glu Asp Pro Glu Pro Gly Ala Phe 
1               5                   10                  15


Thr Thr Thr Lys Arg Thr Gly Ile Pro Ala Pro Arg Glu Phe Ser Val 
            20                  25                  30


Thr Val Ser Arg Glu Arg Ser Val Pro Arg Gly Pro Ser Asn Pro Arg 
        35                  40                  45


Lys Ser Val Ser Ser Pro Thr Ser Ser Asn Thr Pro Thr Pro Thr Lys 
    50                  55                  60


His Leu Arg Thr Pro Ser Thr Lys Pro Lys Gln Glu Asn Glu Gly Gly 
65                  70                  75                  80


Glu Lys Ala Ala Leu Glu Ser Gln Val Arg Glu Leu Leu Ala Glu Ala 
                85                  90                  95


Lys Ala Lys Asp Ser Glu Ile Asn Arg Leu Arg Ser Glu Leu Lys Lys 
            100                 105                 110


Tyr Lys Glu Lys Arg Thr Leu Asn Ala Glu Gly Thr Asp Ala Leu Gly 
        115                 120                 125


Pro Asn Val Asp Gly Thr Ser Val Ser Pro Gly Asp Thr Glu Pro Met 
    130                 135                 140


Ile Arg Ala Leu Glu Glu Lys Asn Lys Asn Phe Gln Lys Glu Leu Ser 
145                 150                 155                 160


Asp Leu Glu Glu Glu Asn Arg Val Leu Lys Glu Lys Leu Ile Tyr Leu 
                165                 170                 175


Glu His Ser Pro Asn Ser Glu Gly Ala Ala Ser His Thr Gly Asp Ser 
            180                 185                 190


Ser Cys Pro Thr Ser Ile Thr Gln Glu Ser Ser Phe Gly Ser Pro Thr 
        195                 200                 205


Gly Asn Gln Met Ser Ser Asp Ile Asp Glu Tyr Lys Lys Asn Ile His 
    210                 215                 220


Gly Asn Ala Leu Arg Thr Ser Gly Ser Ser Ser Ser Asp Val Thr Lys 
225                 230                 235                 240


Ala Ser Leu Ser Pro Asp Ala Ser Asp Phe Glu His Ile Thr Ala Glu 
                245                 250                 255


Thr Pro Ser Arg Pro Leu Ser Ser Thr Ser Asn Pro Phe Lys Ser Ser 
            260                 265                 270


Lys Cys Ser Thr Ala Gly Ser Ser Pro Asn Ser Val Ser Glu Leu Ser 
        275                 280                 285


Leu Ala Ser Leu Thr Glu Lys Ile Gln Lys Met Glu Glu Asn His His 
    290                 295                 300


Ser Thr Ala Glu Glu Leu Gln Ala Thr Leu Gln Glu Leu Ser Asp Gln 
305                 310                 315                 320


Gln Gln Met Val Gln Glu Leu Thr Ala Glu Asn Glu Lys Leu Val Asp 
                325                 330                 335


Glu Lys Thr Ile Leu Glu Thr Ser Phe His Gln His Arg Glu Arg Ala 
            340                 345                 350


Glu Gln Leu Ser Gln Glu Asn Glu Lys Leu Met Asn Leu Leu Gln Glu 
        355                 360                 365


Arg Val Lys Asn Glu Glu Pro Thr Thr Gln Glu Gly Lys Ile Ile Glu 
    370                 375                 380


Leu Glu Gln Lys Cys Thr Gly Ile Leu Glu Gln Gly Arg Phe Glu Arg 
385                 390                 395                 400


Glu Lys Leu Leu Asn Ile Gln Gln Gln Leu Thr Cys Ser Leu Arg Lys 
                405                 410                 415


Val Glu Glu Glu Asn Gln Gly Ala Leu Glu Met Ile Lys Arg Leu Lys 
            420                 425                 430


Glu Glu Asn Glu Lys Leu Asn Glu Phe Leu Glu Leu Glu Arg His Asn 
        435                 440                 445


Asn Asn Met Met Ala Lys Thr Leu Glu Glu Cys Arg Val Thr Leu Glu 
    450                 455                 460


Gly Leu Lys Met Glu Asn Gly Ser Leu Lys Ser His Leu Gln Gly Glu 
465                 470                 475                 480


Lys Gln Lys Ala Thr Glu Ala Ser Ala Val Glu Gln Thr Ala Glu Ser 
                485                 490                 495


Cys Glu Val Gln Glu Met Leu Lys Val Ala Arg Ala Glu Lys Asp Leu 
            500                 505                 510


Leu Glu Leu Ser Cys Asn Glu Leu Arg Gln Glu Leu Leu Lys Ala Asn 
        515                 520                 525


Gly Glu Ile Lys His Val Ser Ser Leu Leu Ala Lys Val Glu Lys Asp 
    530                 535                 540


Tyr Ser Tyr Leu Lys Glu Ile Cys Asp His Gln Ala Glu Gln Leu Ser 
545                 550                 555                 560


Arg Thr Ser Leu Lys Leu Gln Glu Lys Ala Ser Glu Ser Asp Ala Glu 
                565                 570                 575


Ile Lys Asp Met Lys Glu Thr Ile Phe Glu Leu Glu Asp Gln Val Glu 
            580                 585                 590


Gln His Arg Ala Val Lys Leu His Asn Asn Gln Leu Ile Ser Glu Leu 
        595                 600                 605


Glu Ser Ser Val Ile Lys Leu Glu Glu Gln Lys Ser Asp Leu Glu Arg 
    610                 615                 620


Gln Leu Lys Thr Leu Thr Lys Gln Met Lys Glu Glu Thr Glu Glu Trp 
625                 630                 635                 640


Arg Arg Phe Gln Ala Asp Leu Gln Thr Ala Val Val Val Ala Asn Asp 
                645                 650                 655


Ile Lys Cys Glu Ala Gln Gln Glu Leu Arg Thr Val Lys Arg Lys Leu 
            660                 665                 670


Leu Glu Glu Glu Glu Lys Asn Ala Arg Leu Gln Lys Glu Leu Gly Asp 
        675                 680                 685


Val Gln Gly His Gly Arg Val Val Thr Ser Arg Ala Ala Pro Pro Pro 
    690                 695                 700


Val Asp Glu Glu Pro Glu Ser Ser Glu Val Asp Ala Ala Gly Arg Trp 
705                 710                 715                 720


Pro Gly Val Cys Val Ser Arg Thr Ser Pro Thr Pro Pro Glu Ser Ala 
                725                 730                 735


Thr Thr Val Lys Ser Leu Ile Lys Ser Phe Asp Leu Gly Arg Pro Gly 
            740                 745                 750


Gly Ala Gly Gln Asn Ile Ser Val His Lys Thr Pro Arg Ser Pro Leu 
        755                 760                 765


Ser Gly Ile Pro Val Arg Thr Ala Pro Ala Ala Ala Val Ser Pro Met 
    770                 775                 780


Gln Arg His Ser Thr Tyr Ser Ser Val Arg Pro Ala Ser Arg Gly Val 
785                 790                 795                 800


Thr Gln Arg Leu Asp Leu Pro Asp Leu Pro Leu Ser Asp Ile Leu Lys 
                805                 810                 815


Gly Arg Thr Glu Thr Leu Lys Pro Asp Pro His Leu Arg Lys Ser Pro 
            820                 825                 830


Ser Leu Glu Ser Leu Ser Arg Pro Pro Ser Leu Gly Phe Gly Asp Thr 
        835                 840                 845


Arg Leu Leu Ser Ala Ser Thr Arg Ala Trp Lys Pro Gln Ser Lys Leu 
    850                 855                 860


Ser Val Glu Arg Lys Asp Pro Leu Ala Ala Leu Ala Arg Glu Tyr Gly 
865                 870                 875                 880


Gly Ser Lys Arg Asn Ala Leu Leu Lys Trp Cys Gln Lys Lys Thr Gln 
                885                 890                 895


Gly Tyr Ala Asn Ile Asp Ile Thr Asn Phe Ser Ser Ser Trp Ser Asp 
            900                 905                 910


Gly Leu Ala Phe Cys Ala Leu Leu His Thr Tyr Leu Pro Ala His Ile 
        915                 920                 925


Pro Tyr Gln Glu Leu Asn Ser Gln Glu Lys Lys Arg Asn Leu Leu Leu 
    930                 935                 940


Ala Phe Glu Ala Ala Glu Ser Val Gly Ile Lys Pro Ser Leu Glu Leu 
945                 950                 955                 960


Ser Glu Met Leu Tyr Thr Asp Arg Pro Asp Trp Gln Ser Val Met Gln 
                965                 970                 975


Tyr Val Ala Gln Ile Tyr Lys Tyr Phe Glu Thr 
            980                 985


<210>  1129
<211>  2714
<212>  DNA
<213>  Homo sapiens

<400>  1129
agaagcagaa aaggttggat aaaagataag gacagaccca cgaagtcaag catgcggagt     60

gcagccaagc cctggaaccc agccatcaga gcagggggcc acggcccaga ccgggtgcgg    120

cctctgcctg cagcctcttc cggcatgaag agttctaagt cttcaacttc cttggctttt    180

gagtcccgac tcagcaggct caagagggcc agcagtgagg acacgctcaa caagccagga    240

agtaccgctg catcgggggt ggttcgcctg aagaagaccg ccactgccgg agccatctcg    300

gagctcacgg agagccgcct gaggagcggc acaggggcct ttacaacaac taaacggaca    360

ggcattccag ccccacggga attttcagta actgtctcaa gagagaggtc tgtgccacgt    420

ggtccctcca accccaggaa atcagtgtcc agtccaactt cttccaacac tcccactcct    480

acgaaacacc tgaggacccc ttccacaaag cccaagcaag agaatgaagg tggagaaaag    540

gctgcgcttg agtcccaagt tcgggaactt ttggcagaag ccaaagcaaa agatagtgaa    600

attaacaggc ttcgaagtga actaaagaaa tacaaagaga aaaggactct gaacgctgag    660

gggactgatg ctttgggccc aaatgtcgat ggaacatcag tctccccagg tgacacggaa    720

cctatgataa gagctcttga ggagaagaac aagaactttc agaaagagct ttccgatcta    780

gaggaagaaa accgggtcct gaaggagaaa ctgatctatc ttgagcactc cccaaattca    840

gaaggggcag caagtcacac tggcgacagc agctgcccaa catccataac tcaagagtca    900

agcttcggaa gcccaactgg aaatcagatg tccagtgaca ttgatgagta taaaaaaaac    960

atacatggaa atgcattacg gacatcaggc tcctcaagta gcgatgttac caaagcttct   1020

ttgtcgccag atgcttccga ctttgagcac attacagcag agacaccctc aaggcccctg   1080

tcctccacca gtaacccctt taagagttca aagtgttcta ctgctgggag ttccccaaac   1140

agcgtaagtg aattgtccct ggcttccctc acagagaaga tacaaaagat ggaagaaaac   1200

caccatagca ctgcagaaga actacaggct actctacaag aattatcaga ccagcaacaa   1260

atggtacagg aattgacagc tgaaaatgag aagctggtgg atgaaaagac gattttagag   1320

acatcctttc atcagcatcg agagagggca gagcagctaa gtcaagaaaa tgagaagctg   1380

atgaatcttt tacaagagcg agtaaagaat gaagagccca ccactcagga aggaaaaatt   1440

attgaactgg agcagaagtg cacaggtatt cttgaacagg gccgctttga aagagagaag   1500

ctactcaaca ttcagcagca gttgacctgt agcttgcgga aggttgagga agaaaaccaa   1560

ggagctttag aaatgattaa acgtctgaag gaagaaaatg aaaaactgaa tgagtttcta   1620

gaactggaac ggcataataa taacatgatg gccaaaactt tggaagagtg tagagttacc   1680

ttggaagggc taaaaatgga gaatggatct ttgaagtctc atttgcaggg tgagaagcag   1740

aaagccacag aggccagtgc tgtggagcag acggcagaga gctgcgaagt tcaagaaatg   1800

ttgaaagtag cccgagcaga gaaagatcta ctggaactgt cttgcaatga gctcagacaa   1860

gaattactaa aggcaaacgg tgaaattaaa catgtttcca gtctgctggc caaggtggaa   1920

aaggattatt catacctgaa ggagatatgt gatcaccaag ccgaacagct gagcagaacc   1980

agcctaaagc tgcaagaaaa agcatcagag agtgatgcag agatcaaaga catgaaagaa   2040

accatatttg aattggaaga tcaggtggaa cagcaccggg ctgtcaagtt acacaataat   2100

caactcatca gtgagctaga aagtagtgtg atcaagctgg aggaacagaa gtcagacctg   2160

gagaggcagc tgaagactct gaccaagcag atgaaggagg agaccgagga atggaggcgg   2220

ttccaggcgg atctgcagac cgcagtggtg gtggccaatg acatcaagtg tgaggcccag   2280

caggagctgc gcaccgtgaa gaggaaactg ctggaggagg aggagaagaa tgcccggttg   2340

cagaaggagc tgggggatgt gcagggccac ggcagggtgg tcaccagcag agccgcccct   2400

ccctccctgg gctctgtcag ctagcagagc atttggtgga agaaagacag cccagctctt   2460

gccatgattg ggagccgcag ccatctctag atgaaagggg gaatgtgtag aggagaaatt   2520

gcctctttat aaagagccca gttgtctcct tgtgacattc tctgtttctc agagtcattg   2580

ccgtcgagtc tctgcttttt gtccacattt tgggatcagc ttactgcatg atcaaagatg   2640

atgtttccct ctttttactt ttcctcagaa gattgagctg tcttttattt ggagaataaa   2700

atgaagttct gaaa                                                     2714


<210>  1130
<211>  790
<212>  PRT
<213>  Homo sapiens

<400>  1130

Met Arg Ser Ala Ala Lys Pro Trp Asn Pro Ala Ile Arg Ala Gly Gly 
1               5                   10                  15


His Gly Pro Asp Arg Val Arg Pro Leu Pro Ala Ala Ser Ser Gly Met 
            20                  25                  30


Lys Ser Ser Lys Ser Ser Thr Ser Leu Ala Phe Glu Ser Arg Leu Ser 
        35                  40                  45


Arg Leu Lys Arg Ala Ser Ser Glu Asp Thr Leu Asn Lys Pro Gly Ser 
    50                  55                  60


Thr Ala Ala Ser Gly Val Val Arg Leu Lys Lys Thr Ala Thr Ala Gly 
65                  70                  75                  80


Ala Ile Ser Glu Leu Thr Glu Ser Arg Leu Arg Ser Gly Thr Gly Ala 
                85                  90                  95


Phe Thr Thr Thr Lys Arg Thr Gly Ile Pro Ala Pro Arg Glu Phe Ser 
            100                 105                 110


Val Thr Val Ser Arg Glu Arg Ser Val Pro Arg Gly Pro Ser Asn Pro 
        115                 120                 125


Arg Lys Ser Val Ser Ser Pro Thr Ser Ser Asn Thr Pro Thr Pro Thr 
    130                 135                 140


Lys His Leu Arg Thr Pro Ser Thr Lys Pro Lys Gln Glu Asn Glu Gly 
145                 150                 155                 160


Gly Glu Lys Ala Ala Leu Glu Ser Gln Val Arg Glu Leu Leu Ala Glu 
                165                 170                 175


Ala Lys Ala Lys Asp Ser Glu Ile Asn Arg Leu Arg Ser Glu Leu Lys 
            180                 185                 190


Lys Tyr Lys Glu Lys Arg Thr Leu Asn Ala Glu Gly Thr Asp Ala Leu 
        195                 200                 205


Gly Pro Asn Val Asp Gly Thr Ser Val Ser Pro Gly Asp Thr Glu Pro 
    210                 215                 220


Met Ile Arg Ala Leu Glu Glu Lys Asn Lys Asn Phe Gln Lys Glu Leu 
225                 230                 235                 240


Ser Asp Leu Glu Glu Glu Asn Arg Val Leu Lys Glu Lys Leu Ile Tyr 
                245                 250                 255


Leu Glu His Ser Pro Asn Ser Glu Gly Ala Ala Ser His Thr Gly Asp 
            260                 265                 270


Ser Ser Cys Pro Thr Ser Ile Thr Gln Glu Ser Ser Phe Gly Ser Pro 
        275                 280                 285


Thr Gly Asn Gln Met Ser Ser Asp Ile Asp Glu Tyr Lys Lys Asn Ile 
    290                 295                 300


His Gly Asn Ala Leu Arg Thr Ser Gly Ser Ser Ser Ser Asp Val Thr 
305                 310                 315                 320


Lys Ala Ser Leu Ser Pro Asp Ala Ser Asp Phe Glu His Ile Thr Ala 
                325                 330                 335


Glu Thr Pro Ser Arg Pro Leu Ser Ser Thr Ser Asn Pro Phe Lys Ser 
            340                 345                 350


Ser Lys Cys Ser Thr Ala Gly Ser Ser Pro Asn Ser Val Ser Glu Leu 
        355                 360                 365


Ser Leu Ala Ser Leu Thr Glu Lys Ile Gln Lys Met Glu Glu Asn His 
    370                 375                 380


His Ser Thr Ala Glu Glu Leu Gln Ala Thr Leu Gln Glu Leu Ser Asp 
385                 390                 395                 400


Gln Gln Gln Met Val Gln Glu Leu Thr Ala Glu Asn Glu Lys Leu Val 
                405                 410                 415


Asp Glu Lys Thr Ile Leu Glu Thr Ser Phe His Gln His Arg Glu Arg 
            420                 425                 430


Ala Glu Gln Leu Ser Gln Glu Asn Glu Lys Leu Met Asn Leu Leu Gln 
        435                 440                 445


Glu Arg Val Lys Asn Glu Glu Pro Thr Thr Gln Glu Gly Lys Ile Ile 
    450                 455                 460


Glu Leu Glu Gln Lys Cys Thr Gly Ile Leu Glu Gln Gly Arg Phe Glu 
465                 470                 475                 480


Arg Glu Lys Leu Leu Asn Ile Gln Gln Gln Leu Thr Cys Ser Leu Arg 
                485                 490                 495


Lys Val Glu Glu Glu Asn Gln Gly Ala Leu Glu Met Ile Lys Arg Leu 
            500                 505                 510


Lys Glu Glu Asn Glu Lys Leu Asn Glu Phe Leu Glu Leu Glu Arg His 
        515                 520                 525


Asn Asn Asn Met Met Ala Lys Thr Leu Glu Glu Cys Arg Val Thr Leu 
    530                 535                 540


Glu Gly Leu Lys Met Glu Asn Gly Ser Leu Lys Ser His Leu Gln Gly 
545                 550                 555                 560


Glu Lys Gln Lys Ala Thr Glu Ala Ser Ala Val Glu Gln Thr Ala Glu 
                565                 570                 575


Ser Cys Glu Val Gln Glu Met Leu Lys Val Ala Arg Ala Glu Lys Asp 
            580                 585                 590


Leu Leu Glu Leu Ser Cys Asn Glu Leu Arg Gln Glu Leu Leu Lys Ala 
        595                 600                 605


Asn Gly Glu Ile Lys His Val Ser Ser Leu Leu Ala Lys Val Glu Lys 
    610                 615                 620


Asp Tyr Ser Tyr Leu Lys Glu Ile Cys Asp His Gln Ala Glu Gln Leu 
625                 630                 635                 640


Ser Arg Thr Ser Leu Lys Leu Gln Glu Lys Ala Ser Glu Ser Asp Ala 
                645                 650                 655


Glu Ile Lys Asp Met Lys Glu Thr Ile Phe Glu Leu Glu Asp Gln Val 
            660                 665                 670


Glu Gln His Arg Ala Val Lys Leu His Asn Asn Gln Leu Ile Ser Glu 
        675                 680                 685


Leu Glu Ser Ser Val Ile Lys Leu Glu Glu Gln Lys Ser Asp Leu Glu 
    690                 695                 700


Arg Gln Leu Lys Thr Leu Thr Lys Gln Met Lys Glu Glu Thr Glu Glu 
705                 710                 715                 720


Trp Arg Arg Phe Gln Ala Asp Leu Gln Thr Ala Val Val Val Ala Asn 
                725                 730                 735


Asp Ile Lys Cys Glu Ala Gln Gln Glu Leu Arg Thr Val Lys Arg Lys 
            740                 745                 750


Leu Leu Glu Glu Glu Glu Lys Asn Ala Arg Leu Gln Lys Glu Leu Gly 
        755                 760                 765


Asp Val Gln Gly His Gly Arg Val Val Thr Ser Arg Ala Ala Pro Pro 
    770                 775                 780


Ser Leu Gly Ser Val Ser 
785                 790


<210>  1131
<211>  416
<212>  DNA
<213>  Homo sapiens

<400>  1131
atggtccagc gtttgacata cattgtaggc tttcctacaa tacagcctct aacaaaacta     60

ggctgtcccg aaccaaaact aggctgtccc gaacccctgg taatagaatt gtttatcttt    120

ataccaagaa gtttgggaaa gcaccaaaat ctgcatgtgg catgtgccca ggcagacttc    180

aagtggttcc tgctgtaaga cctaaagttc ttatgagatt gtccaaaaca aaggaacatg    240

tcagcagggc ctgtggtggt tccatgtgtg ctaaatgtgt tcgtgacagg atcaagcatg    300

ctttccttac tgaggagcag aaaatcgttg tgaaagtgtt gaaggcacaa gcacaaagtc    360

agaaaacgaa attaaaaaat gaaacttttt tgagtaataa aaatgaaaag acttaa        416


<210>  1132
<211>  2849
<212>  DNA
<213>  Homo sapiens

<400>  1132
agatatctcc ggcgccgccc gccattttga ctccagtgtc tcgtttgcag tcggcgcttt     60

aggggaactg tcttcctccg caggcgcgag gctgggtaca gggtctattg tctgtggttg    120

actccgtact ttggtctgag gccttcggga gctttcccga ggcagttagc agaagccgca    180

gcggccgccc ccgcccgtct cctctgtccc tgggcccggg agggaccaac ttggcgtcac    240

gcccctcagc ggtcgccact ctcttctctg ttgttgggtc cgcatcgtat tcccggaatc    300

agacggtgcc ccatagatgg ccagctttcc cccgagggtc aacgagaaag agatcgtgag    360

attacgtact ataggtgaac ttttagctcc tgcagctcct tttgacaaga aatgtggtcg    420

tgaaaattgg actgttgctt ttgctccaga tggttcatac tttgcttggt cacaaggaca    480

tcgcacagta aagcttgttc cgtggtccca gtgccttcag aactttctct tgcatggcac    540

caagaatgtt accaattcaa gcagtttaag attgccaaga caaaatagtg atggtggtca    600

gaaaaataag cctcgtgaac atattataga ctgtggagat atagtctgga gtcttgcttt    660

tgggtcatca gttccagaaa aacagagtcg ctgtgtaaat atagaatggc atcgcttcag    720

atttggacaa gatcagctac ttcttgctac agggttgaac aatgggcgta tcaaaatatg    780

ggatgtatat acaggaaaac tcctccttaa cttggtagat catactgaag tggtcagaga    840

tttaactttt gctccagatg gaagcttgat cctggtgtca gcttcaagag acaaaactct    900

cagagtatgg gacctgaaag atgatggaaa catgatgaaa gtattgaggg ggcatcagaa    960

ttgggtgtac agctgtgcat tctctcctga ctcttctatg ctgtgttcag tcggagccag   1020

taaagcagtt ttcctttgga atatggataa atacaccatg atacggaaac tagaaggaca   1080

tcaccatgat gtggtagctt gtgacttttc tcctgatgga gcattactgg ctactgcatc   1140

ttatgatact cgagtatata tctgggatcc acataatgga gacattctga tggaatttgg   1200

gcacctgttt cccccaccta ctccaatatt tgctggagga gcaaatgacc ggtgggtacg   1260

atctgtatct tttagccatg atggactgca tgttgcaagc cttgctgatg ataaaatggt   1320

gaggttctgg agaattgatg aggattatcc agtgcaagtt gcacctttga gcaatggtct   1380

ttgctgtgcc ttctctactg atggcagtgt tttagctgct gggacacatg acggaagtgt   1440

gtatttttgg gccactccac ggcaggtccc tagcctgcaa catttatgtc gcatgtcaat   1500

ccgaagagtg atgcccaccc aagaagttca ggagctgccg attccttcca agcttttgga   1560

gtttctctcg tatcgtattt agaagattct gccttcccta gtagtaggga ctgacagaat   1620

acacttaaca caaacctcaa gctttactga cttcaattat ctgtttttaa agacgtagaa   1680

gatttattta atttgatatg ttcttgtact gcattttgat cagttgagct tttaaaatat   1740

tatttataga caatagaagt atttctgaac atatcaaata taaatttttt taaagatcta   1800

actgtgaaaa catacatacc tgtacatatt tagatataag ctgctatatg ttgaatggac   1860

ccttttgctt ttctgatttt tagttctgac atgtatatat tgcttcagta gagccacaat   1920

atgtatcttt gctgtaaagt gcaaggaaat tttaaattct gggacactga gttagatggt   1980

aaatactgac ttacgaaagt tgaattgggt gaggcgggca aatcacctga ggtcagcagt   2040

ttgagactag cctggcaaac atgatgaaac cctgtctcta ctaaaaatac aaaaaaaaaa   2100

aaaattagcc aggcgtggtg gtgcacacct gtagtcctag ctacttggga ggctgaggca   2160

ggagaattgc ttgaacccag gaggtggagg ttgcagtaag ccaagatcac accactgcac   2220

tccaacctgg acaacagagc gagactccat ctcaaaaaaa aaaaaaaatt gtgttgcctc   2280

atacgaaatg tatttggttt tgttggagag tgtcagactg atctggaagt gaaacacagt   2340

ttatgtacag ggaaaaggat tttattatcc ttaggaatgt catccaagac gtagagcttg   2400

aatgtgacgt tatttaaaaa caacaacaaa gaaggcagag ccaggatata actagaaaaa   2460

ggatgtcttt tttttttttt ttactccccc tctaaacact gctgctgcct taattttaga   2520

aagcagctta ctagtttacc cttgtggtat aaagtattat aaattgttgt gaatttgaag   2580

aatccgtcta ctgtattatt gctaaatatt ttgtttatac taagggacaa ttattttaag   2640

accatggatt taaaaaaaaa aaaaaaaact ctgtttctgc aggggatgat attggtgagt   2700

tgccaaagaa gcaatacagc atatctgctt ttgccttctg ttgtttatct tacctgcaga   2760

tattaagaat gtatgcatta tgtaaaatgc tcaattatat atttttgttg agttttttaa   2820

ttaaagactt gttaaaaaaa aaaaaaaaa                                     2849


<210>  1133
<211>  421
<212>  PRT
<213>  Homo sapiens

<400>  1133

Met Ala Ser Phe Pro Pro Arg Val Asn Glu Lys Glu Ile Val Arg Leu 
1               5                   10                  15


Arg Thr Ile Gly Glu Leu Leu Ala Pro Ala Ala Pro Phe Asp Lys Lys 
            20                  25                  30


Cys Gly Arg Glu Asn Trp Thr Val Ala Phe Ala Pro Asp Gly Ser Tyr 
        35                  40                  45


Phe Ala Trp Ser Gln Gly His Arg Thr Val Lys Leu Val Pro Trp Ser 
    50                  55                  60


Gln Cys Leu Gln Asn Phe Leu Leu His Gly Thr Lys Asn Val Thr Asn 
65                  70                  75                  80


Ser Ser Ser Leu Arg Leu Pro Arg Gln Asn Ser Asp Gly Gly Gln Lys 
                85                  90                  95


Asn Lys Pro Arg Glu His Ile Ile Asp Cys Gly Asp Ile Val Trp Ser 
            100                 105                 110


Leu Ala Phe Gly Ser Ser Val Pro Glu Lys Gln Ser Arg Cys Val Asn 
        115                 120                 125


Ile Glu Trp His Arg Phe Arg Phe Gly Gln Asp Gln Leu Leu Leu Ala 
    130                 135                 140


Thr Gly Leu Asn Asn Gly Arg Ile Lys Ile Trp Asp Val Tyr Thr Gly 
145                 150                 155                 160


Lys Leu Leu Leu Asn Leu Val Asp His Thr Glu Val Val Arg Asp Leu 
                165                 170                 175


Thr Phe Ala Pro Asp Gly Ser Leu Ile Leu Val Ser Ala Ser Arg Asp 
            180                 185                 190


Lys Thr Leu Arg Val Trp Asp Leu Lys Asp Asp Gly Asn Met Met Lys 
        195                 200                 205


Val Leu Arg Gly His Gln Asn Trp Val Tyr Ser Cys Ala Phe Ser Pro 
    210                 215                 220


Asp Ser Ser Met Leu Cys Ser Val Gly Ala Ser Lys Ala Val Phe Leu 
225                 230                 235                 240


Trp Asn Met Asp Lys Tyr Thr Met Ile Arg Lys Leu Glu Gly His His 
                245                 250                 255


His Asp Val Val Ala Cys Asp Phe Ser Pro Asp Gly Ala Leu Leu Ala 
            260                 265                 270


Thr Ala Ser Tyr Asp Thr Arg Val Tyr Ile Trp Asp Pro His Asn Gly 
        275                 280                 285


Asp Ile Leu Met Glu Phe Gly His Leu Phe Pro Pro Pro Thr Pro Ile 
    290                 295                 300


Phe Ala Gly Gly Ala Asn Asp Arg Trp Val Arg Ser Val Ser Phe Ser 
305                 310                 315                 320


His Asp Gly Leu His Val Ala Ser Leu Ala Asp Asp Lys Met Val Arg 
                325                 330                 335


Phe Trp Arg Ile Asp Glu Asp Tyr Pro Val Gln Val Ala Pro Leu Ser 
            340                 345                 350


Asn Gly Leu Cys Cys Ala Phe Ser Thr Asp Gly Ser Val Leu Ala Ala 
        355                 360                 365


Gly Thr His Asp Gly Ser Val Tyr Phe Trp Ala Thr Pro Arg Gln Val 
    370                 375                 380


Pro Ser Leu Gln His Leu Cys Arg Met Ser Ile Arg Arg Val Met Pro 
385                 390                 395                 400


Thr Gln Glu Val Gln Glu Leu Pro Ile Pro Ser Lys Leu Leu Glu Phe 
                405                 410                 415


Leu Ser Tyr Arg Ile 
            420


<210>  1134
<211>  2411
<212>  DNA
<213>  Homo sapiens

<400>  1134
agatatctcc ggcgccgccc gccattttga ctccagtgtc tcgtttgcag tcggcgcttt     60

aggggaactg tcttcctccg caggcgcgag gctgggtaca gggtctattg tctgtggttg    120

actccgtact ttggtctgag gccttcggga gctttcccga ggcagttagc agaagccgca    180

gcggccgccc ccgcccgtct cctctgtccc tgggcccggg agggaccaac ttggcgtcac    240

gcccctcagc ggtcgccact ctcttctctg ttgttgggtc cgcatcgtat tcccggaatc    300

agacggtgcc ccatagatgg ccagctttcc cccgagggtc aacgagaaag agatcggaaa    360

actcctcctt aacttggtag atcatactga agtggtcaga gatttaactt ttgctccaga    420

tggaagcttg atcctggtgt cagcttcaag agacaaaact ctcagagtat gggacctgaa    480

agatgatgga aacatgatga aagtattgag ggggcatcag aattgggtgt acagctgtgc    540

attctctcct gactcttcta tgctgtgttc agtcggagcc agtaaagcag ttttcctttg    600

gaatatggat aaatacacca tgatacggaa actagaagga catcaccatg atgtggtagc    660

ttgtgacttt tctcctgatg gagcattact ggctactgca tcttatgata ctcgagtata    720

tatctgggat ccacataatg gagacattct gatggaattt gggcacctgt ttcccccacc    780

tactccaata tttgctggag gagcaaatga ccggtgggta cgatctgtat cttttagcca    840

tgatggactg catgttgcaa gccttgctga tgataaaatg gtgaggttct ggagaattga    900

tgaggattat ccagtgcaag ttgcaccttt gagcaatggt ctttgctgtg ccttctctac    960

tgatggcagt gttttagctg ctgggacaca tgacggaagt gtgtattttt gggccactcc   1020

acggcaggtc cctagcctgc aacatttatg tcgcatgtca atccgaagag tgatgcccac   1080

ccaagaagtt caggagctgc cgattccttc caagcttttg gagtttctct cgtatcgtat   1140

ttagaagatt ctgccttccc tagtagtagg gactgacaga atacacttaa cacaaacctc   1200

aagctttact gacttcaatt atctgttttt aaagacgtag aagatttatt taatttgata   1260

tgttcttgta ctgcattttg atcagttgag cttttaaaat attatttata gacaatagaa   1320

gtatttctga acatatcaaa tataaatttt tttaaagatc taactgtgaa aacatacata   1380

cctgtacata tttagatata agctgctata tgttgaatgg acccttttgc ttttctgatt   1440

tttagttctg acatgtatat attgcttcag tagagccaca atatgtatct ttgctgtaaa   1500

gtgcaaggaa attttaaatt ctgggacact gagttagatg gtaaatactg acttacgaaa   1560

gttgaattgg gtgaggcggg caaatcacct gaggtcagca gtttgagact agcctggcaa   1620

acatgatgaa accctgtctc tactaaaaat acaaaaaaaa aaaaaattag ccaggcgtgg   1680

tggtgcacac ctgtagtcct agctacttgg gaggctgagg caggagaatt gcttgaaccc   1740

aggaggtgga ggttgcagta agccaagatc acaccactgc actccaacct ggacaacaga   1800

gcgagactcc atctcaaaaa aaaaaaaaaa ttgtgttgcc tcatacgaaa tgtatttggt   1860

tttgttggag agtgtcagac tgatctggaa gtgaaacaca gtttatgtac agggaaaagg   1920

attttattat ccttaggaat gtcatccaag acgtagagct tgaatgtgac gttatttaaa   1980

aacaacaaca aagaaggcag agccaggata taactagaaa aaggatgtct tttttttttt   2040

ttttactccc cctctaaaca ctgctgctgc cttaatttta gaaagcagct tactagttta   2100

cccttgtggt ataaagtatt ataaattgtt gtgaatttga agaatccgtc tactgtatta   2160

ttgctaaata ttttgtttat actaagggac aattatttta agaccatgga tttaaaaaaa   2220

aaaaaaaaaa ctctgtttct gcaggggatg atattggtga gttgccaaag aagcaataca   2280

gcatatctgc ttttgccttc tgttgtttat cttacctgca gatattaaga atgtatgcat   2340

tatgtaaaat gctcaattat atatttttgt tgagtttttt aattaaagac ttgttaaaaa   2400

aaaaaaaaaa a                                                        2411


<210>  1135
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  1135

Met Ala Ser Phe Pro Pro Arg Val Asn Glu Lys Glu Ile Gly Lys Leu 
1               5                   10                  15


Leu Leu Asn Leu Val Asp His Thr Glu Val Val Arg Asp Leu Thr Phe 
            20                  25                  30


Ala Pro Asp Gly Ser Leu Ile Leu Val Ser Ala Ser Arg Asp Lys Thr 
        35                  40                  45


Leu Arg Val Trp Asp Leu Lys Asp Asp Gly Asn Met Met Lys Val Leu 
    50                  55                  60


Arg Gly His Gln Asn Trp Val Tyr Ser Cys Ala Phe Ser Pro Asp Ser 
65                  70                  75                  80


Ser Met Leu Cys Ser Val Gly Ala Ser Lys Ala Val Phe Leu Trp Asn 
                85                  90                  95


Met Asp Lys Tyr Thr Met Ile Arg Lys Leu Glu Gly His His His Asp 
            100                 105                 110


Val Val Ala Cys Asp Phe Ser Pro Asp Gly Ala Leu Leu Ala Thr Ala 
        115                 120                 125


Ser Tyr Asp Thr Arg Val Tyr Ile Trp Asp Pro His Asn Gly Asp Ile 
    130                 135                 140


Leu Met Glu Phe Gly His Leu Phe Pro Pro Pro Thr Pro Ile Phe Ala 
145                 150                 155                 160


Gly Gly Ala Asn Asp Arg Trp Val Arg Ser Val Ser Phe Ser His Asp 
                165                 170                 175


Gly Leu His Val Ala Ser Leu Ala Asp Asp Lys Met Val Arg Phe Trp 
            180                 185                 190


Arg Ile Asp Glu Asp Tyr Pro Val Gln Val Ala Pro Leu Ser Asn Gly 
        195                 200                 205


Leu Cys Cys Ala Phe Ser Thr Asp Gly Ser Val Leu Ala Ala Gly Thr 
    210                 215                 220


His Asp Gly Ser Val Tyr Phe Trp Ala Thr Pro Arg Gln Val Pro Ser 
225                 230                 235                 240


Leu Gln His Leu Cys Arg Met Ser Ile Arg Arg Val Met Pro Thr Gln 
                245                 250                 255


Glu Val Gln Glu Leu Pro Ile Pro Ser Lys Leu Leu Glu Phe Leu Ser 
            260                 265                 270


Tyr Arg Ile 
        275


<210>  1136
<211>  1506
<212>  DNA
<213>  Homo sapiens

<400>  1136
gcgcttctga caagcccgaa agtcatttcc aatctcaagt ggactttgtt ccaactattg     60

ggggcgtcgc tccccctctt catggtcgcg ggcaaacttc ctcctcggcg cctcttctaa    120

tggagcccca cctgctcggg ctgctcctcg gcctcctgct cggtggcacc agggtcctcg    180

ctggctaccc aatttggtgg tccctggccc tgggccagca gtacacatct ctgggctcac    240

agcccctgct ctgcggctcc atcccaggcc tggtccccaa gcaactgcgc ttctgccgca    300

attacatcga gatcatgccc agcgtggccg agggcgtgaa gctgggcatc caggagtgcc    360

agcaccagtt ccggggccgc cgctggaact gcaccaccat agatgacagc ctggccatct    420

ttgggcccgt cctcgacaaa gccacccgcg agtcggcctt cgttcacgcc atcgcctcgg    480

ccggcgtggc cttcgccgtc acccgctcct gcgccgaggg cacctccacc atttgcggct    540

gtgactcgca tcataagggg ccgcctggcg aaggctggaa gtggggcggc tgcagcgagg    600

acgctgactt cggcgtgtta gtgtccaggg agttcgcgga tgcgcgcgag aacaggccgg    660

acgcgcgctc ggccatgaac aagcacaaca acgaggcggg ccgcacgact atcctggacc    720

acatgcacct caaatgcaag tgccacgggc tgtcgggcag ctgtgaggtg aagacctgct    780

ggtgggcgca gcctgacttc cgtgccatcg gtgacttcct caaggacaag tatgacagcg    840

cctcggagat ggtagtagag aagcaccgtg agtcccgagg ctgggtggag accctccggg    900

ccaagtactc gctcttcaag ccacccacgg agagggacct ggtctactac gagaactccc    960

ccaacttttg tgagcccaac ccagagacgg gttcctttgg cacaagggac cggacttgca   1020

atgtcacctc ccacggcatc gatggctgcg atctgctctg ctgtggccgg ggccacaaca   1080

cgaggacgga gaagcggaag gaaaaatgcc actgcatctt ccactggtgc tgctacgtca   1140

gctgccagga gtgtattcgc atctacgacg tgcacacctg caagtagggc accagggcgc   1200

tgggaagggg tgaagtgtgt ggctgggcgg attcagcgaa gtctcatggg aagcaggacc   1260

tagagccggg cacagccctc agcgtcagac agcaaggaac tgtcaccagc cgcacgcgtg   1320

gtaaatgacc cagacccaac tcgcctgtgg acggggaggc tctccctctc tctcatctta   1380

catttctcac cctactctgg atggtgtgtg gtttttaaag aagggggctt tctttttagt   1440

tctctagggt ctgataggaa cagacctgag gcttatcttt gcacatgtta aagaaaaaaa   1500

aaaaaa                                                              1506


<210>  1137
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  1137

Met Glu Pro His Leu Leu Gly Leu Leu Leu Gly Leu Leu Leu Gly Gly 
1               5                   10                  15


Thr Arg Val Leu Ala Gly Tyr Pro Ile Trp Trp Ser Leu Ala Leu Gly 
            20                  25                  30


Gln Gln Tyr Thr Ser Leu Gly Ser Gln Pro Leu Leu Cys Gly Ser Ile 
        35                  40                  45


Pro Gly Leu Val Pro Lys Gln Leu Arg Phe Cys Arg Asn Tyr Ile Glu 
    50                  55                  60


Ile Met Pro Ser Val Ala Glu Gly Val Lys Leu Gly Ile Gln Glu Cys 
65                  70                  75                  80


Gln His Gln Phe Arg Gly Arg Arg Trp Asn Cys Thr Thr Ile Asp Asp 
                85                  90                  95


Ser Leu Ala Ile Phe Gly Pro Val Leu Asp Lys Ala Thr Arg Glu Ser 
            100                 105                 110


Ala Phe Val His Ala Ile Ala Ser Ala Gly Val Ala Phe Ala Val Thr 
        115                 120                 125


Arg Ser Cys Ala Glu Gly Thr Ser Thr Ile Cys Gly Cys Asp Ser His 
    130                 135                 140


His Lys Gly Pro Pro Gly Glu Gly Trp Lys Trp Gly Gly Cys Ser Glu 
145                 150                 155                 160


Asp Ala Asp Phe Gly Val Leu Val Ser Arg Glu Phe Ala Asp Ala Arg 
                165                 170                 175


Glu Asn Arg Pro Asp Ala Arg Ser Ala Met Asn Lys His Asn Asn Glu 
            180                 185                 190


Ala Gly Arg Thr Thr Ile Leu Asp His Met His Leu Lys Cys Lys Cys 
        195                 200                 205


His Gly Leu Ser Gly Ser Cys Glu Val Lys Thr Cys Trp Trp Ala Gln 
    210                 215                 220


Pro Asp Phe Arg Ala Ile Gly Asp Phe Leu Lys Asp Lys Tyr Asp Ser 
225                 230                 235                 240


Ala Ser Glu Met Val Val Glu Lys His Arg Glu Ser Arg Gly Trp Val 
                245                 250                 255


Glu Thr Leu Arg Ala Lys Tyr Ser Leu Phe Lys Pro Pro Thr Glu Arg 
            260                 265                 270


Asp Leu Val Tyr Tyr Glu Asn Ser Pro Asn Phe Cys Glu Pro Asn Pro 
        275                 280                 285


Glu Thr Gly Ser Phe Gly Thr Arg Asp Arg Thr Cys Asn Val Thr Ser 
    290                 295                 300


His Gly Ile Asp Gly Cys Asp Leu Leu Cys Cys Gly Arg Gly His Asn 
305                 310                 315                 320


Thr Arg Thr Glu Lys Arg Lys Glu Lys Cys His Cys Ile Phe His Trp 
                325                 330                 335


Cys Cys Tyr Val Ser Cys Gln Glu Cys Ile Arg Ile Tyr Asp Val His 
            340                 345                 350


Thr Cys Lys 
        355


<210>  1138
<211>  3570
<212>  DNA
<213>  Homo sapiens

<400>  1138
gcggccgcgg tgaagcgcgg agggcggcgc gggcaccggg gccgggccgg ggctgcagcc     60

gcagcggcca tgggggccct gacgagccgg cagcacgcgg gcgtggagga ggtggacatc    120

ccgtctaatt ccgtgtaccg ctacccgccc aagtccggaa gctattttgc cagccacttc    180

attatgggag gagagaagtt tgactcaact catcctgaag gttacctgtt tggagagaac    240

agcgatctga actttctggg gaacagacca gttgtgtttc cttacgccgc cccacctccc    300

caagaacccg tgaagactct gagaagcctg gtcaatatcc gaaaggacac actgaggctc    360

gtcaaatgtg ctgaggaagt gaagagccct ggagaagagg ccagtaaagc taaagtccac    420

tataatgttg agttcacctt tgacacagat gctcgggtag ccatcaccat ctattaccag    480

gccacggaag agttccagaa tggtattgcc agctacattc ccaaagacaa cagcctccag    540

tcggagactg tgcagtacaa gcgaggagtg tgtcagcagt tctgcctgcc ctcccacacc    600

gtggatccct ccgagtgggc cgaagaggag cttggctttg atttagaccg agaagtttac    660

cctctagtgg tacatgccgt ggtggatgaa ggagacgagt attttggcca ttgccatgta    720

ctgctgggta cttttgagaa gcacacagat ggaactttct gtgtcaagcc cctcaaacag    780

aaacaagtag tagacggggt cagctacctc cttcaggaga tctatggaat tgaaaacaag    840

tacaacacac aagattctaa ggtggctgaa gacgaagtga gtgataacag tgccgagtgt    900

gtggtgtgtc tctcggatgt ccgggacacc ttgattctgc cctgtcgcca cctctgcctc    960

tgtaacacct gtgcagacac gctgcgctac caggccaaca actgccccat ctgccgactg   1020

cccttccggg cactgcttca gatccgagcc atgaggaaaa aattgggccc cttgtcccca   1080

accagcttta accccatcat ctcatcccag acatctgact ctgaagagca tccatcctca   1140

gagaatattc caccaggcta tgaagtagta tctcttctgg aggccctcaa cgggcccctc   1200

accccgtccc cagcagttcc tccacttcac gtgcttggag atggccacct ctcaggaatg   1260

ctcccttcat atggcagtga tggccacctg ccccccgtca ggacgatctc gcctcttgac   1320

cgcctgtctg acagcagcag tcagggactc aaactcaaaa agagtctctc caaatccact   1380

tcccaaaact cttccgtgct gcatgaagag gaagatgagc attcctgcag cgagtcggag   1440

acacagctct ctcagagacc gtcggttcag catctcggag aggaatgtgg tgtgactcca   1500

gaaagtgaga atctcaccct gtcgtcatct ggagctattg accagtcgtc ttgcacaggg   1560

acgcctctgt catccactat ttcctcccca gaaggccctg ccagcagcag cttggcccag   1620

tctgtcatgt ccatggcatc ctcccagatc agcactgaca ccgtctcctc catgtctggc   1680

tcctacatcg cccctggcac tgaagaggag ggagaggctc tctcttcccc ccagcctgcc   1740

agcagggccc cctcagaaga aggagagggg ctgccagcgg agtctccaga cagcaacttt   1800

gctggcctcc cagctggaga gcaggatgca gagggaaatg atgttataga ggaagaggat   1860

ggatcaccca cgcaggaagg ccagaggacg tgcgcatttc taggtatgga gtgtgacaat   1920

aacaatgact ttgacatcgc aagcgtgaaa gcactggaca ataagctgtg ctctgaggtc   1980

tgcttacctg gtgcctggca ggctgatgac aatgccgtca gtcggaatgc ccagcgccgg   2040

cgcttgtcat ccagcagcct ggaggactct gagacgaggc cctgtgtgtg gggccctttg   2100

gctgtctgag ccccagcctc tgcacttggg ctcccctcct gccctgcatt ccatccatcc   2160

tcactcagct gctgcctact gggcatcctc agcaagatgc tggagacttt ttaccctcct   2220

gtgacagctg ttacaacctg taaccacaat ccctcacctc tcagagggaa ctggaaccct   2280

cctttctccg tgtgacctaa agccactcaa tgaactgcag ctcacgagac cttttgcagg   2340

gactctggaa tgtcctcacg gtatattgat gttcaggtgg agctggggtc catgggctaa   2400

tttcttacac atcttttttc tccttagggg gtagaacaag aaggcttaga gtttggcagc   2460

tttgttacaa acatccctct ggcatttcct ggtctctggc acatcataac caattggaaa   2520

cctgcagttt ggggtagggc tggaggatcg ctcctgtgga aagggagagc catactgcac   2580

ggacgtagcg tttccctcta caagcactag gagcaccttt ctcaaggaca agaaatggta   2640

gcaaccaaaa ggttggttga aggaaacaat ccttccttct ggtggcagag ccagtcttct   2700

gggcctcaca tgcctgtgcg gttaagaagg agctcttggc cgggcgcggt ggctcacgcc   2760

tgtaatctca gcactttggg aggccgaggc gggtggatca tgagatcagg agatcgagac   2820

catcctggct aacacggcga aaccccgtct ctactaaaaa tacaaaaaat tagctgggca   2880

tggttgcagg cgcctgtagt cccagctact tgggaggctg aggcaggaga atggcctgaa   2940

cccgggaggc ggagcttgca gtgagccgag atcgcgccaa tgcactccag cctgggcgac   3000

agagaaaaaa aaaaaaaaaa gaaggagccc ttgaatctga gaatccccca gttaagatga   3060

tttcccttaa ggagcatttc tcctgatcag gtgcattcag ggaggcctgc aactccatcc   3120

taaggtgaca tttcaagaaa cacatgtgtt gaccacctct gtgtgccaag cactgggtga   3180

ggagtggtcg tatattacca taattcatcc tcactcaatt gggaggtggc attcttgtcc   3240

ctgttgcccc catctctacc cccttttgtt aatggttgag agaaatgtgg accagtgatt   3300

ctcagtttgg tgcccaggtc cccaaaggaa gtgatggaga gccttgagct aagttcaggc   3360

agcagcatgt ggccagcagc agtgtgctgg gagcagaggt tggaatcagg gctcagggcc   3420

ttcacttcaa gggccctccc cagctactcg ggaggctgag gcaggagaat cgcttgaact   3480

caggaggtgg aggttgcggt gagccaagat cgtgccactg cactccagcc tgggctacaa   3540

gattgaaaag atcgaaactc tgtctcaaac                                    3570


<210>  1139
<211>  679
<212>  PRT
<213>  Homo sapiens

<400>  1139

Met Gly Ala Leu Thr Ser Arg Gln His Ala Gly Val Glu Glu Val Asp 
1               5                   10                  15


Ile Pro Ser Asn Ser Val Tyr Arg Tyr Pro Pro Lys Ser Gly Ser Tyr 
            20                  25                  30


Phe Ala Ser His Phe Ile Met Gly Gly Glu Lys Phe Asp Ser Thr His 
        35                  40                  45


Pro Glu Gly Tyr Leu Phe Gly Glu Asn Ser Asp Leu Asn Phe Leu Gly 
    50                  55                  60


Asn Arg Pro Val Val Phe Pro Tyr Ala Ala Pro Pro Pro Gln Glu Pro 
65                  70                  75                  80


Val Lys Thr Leu Arg Ser Leu Val Asn Ile Arg Lys Asp Thr Leu Arg 
                85                  90                  95


Leu Val Lys Cys Ala Glu Glu Val Lys Ser Pro Gly Glu Glu Ala Ser 
            100                 105                 110


Lys Ala Lys Val His Tyr Asn Val Glu Phe Thr Phe Asp Thr Asp Ala 
        115                 120                 125


Arg Val Ala Ile Thr Ile Tyr Tyr Gln Ala Thr Glu Glu Phe Gln Asn 
    130                 135                 140


Gly Ile Ala Ser Tyr Ile Pro Lys Asp Asn Ser Leu Gln Ser Glu Thr 
145                 150                 155                 160


Val Gln Tyr Lys Arg Gly Val Cys Gln Gln Phe Cys Leu Pro Ser His 
                165                 170                 175


Thr Val Asp Pro Ser Glu Trp Ala Glu Glu Glu Leu Gly Phe Asp Leu 
            180                 185                 190


Asp Arg Glu Val Tyr Pro Leu Val Val His Ala Val Val Asp Glu Gly 
        195                 200                 205


Asp Glu Tyr Phe Gly His Cys His Val Leu Leu Gly Thr Phe Glu Lys 
    210                 215                 220


His Thr Asp Gly Thr Phe Cys Val Lys Pro Leu Lys Gln Lys Gln Val 
225                 230                 235                 240


Val Asp Gly Val Ser Tyr Leu Leu Gln Glu Ile Tyr Gly Ile Glu Asn 
                245                 250                 255


Lys Tyr Asn Thr Gln Asp Ser Lys Val Ala Glu Asp Glu Val Ser Asp 
            260                 265                 270


Asn Ser Ala Glu Cys Val Val Cys Leu Ser Asp Val Arg Asp Thr Leu 
        275                 280                 285


Ile Leu Pro Cys Arg His Leu Cys Leu Cys Asn Thr Cys Ala Asp Thr 
    290                 295                 300


Leu Arg Tyr Gln Ala Asn Asn Cys Pro Ile Cys Arg Leu Pro Phe Arg 
305                 310                 315                 320


Ala Leu Leu Gln Ile Arg Ala Met Arg Lys Lys Leu Gly Pro Leu Ser 
                325                 330                 335


Pro Thr Ser Phe Asn Pro Ile Ile Ser Ser Gln Thr Ser Asp Ser Glu 
            340                 345                 350


Glu His Pro Ser Ser Glu Asn Ile Pro Pro Gly Tyr Glu Val Val Ser 
        355                 360                 365


Leu Leu Glu Ala Leu Asn Gly Pro Leu Thr Pro Ser Pro Ala Val Pro 
    370                 375                 380


Pro Leu His Val Leu Gly Asp Gly His Leu Ser Gly Met Leu Pro Ser 
385                 390                 395                 400


Tyr Gly Ser Asp Gly His Leu Pro Pro Val Arg Thr Ile Ser Pro Leu 
                405                 410                 415


Asp Arg Leu Ser Asp Ser Ser Ser Gln Gly Leu Lys Leu Lys Lys Ser 
            420                 425                 430


Leu Ser Lys Ser Thr Ser Gln Asn Ser Ser Val Leu His Glu Glu Glu 
        435                 440                 445


Asp Glu His Ser Cys Ser Glu Ser Glu Thr Gln Leu Ser Gln Arg Pro 
    450                 455                 460


Ser Val Gln His Leu Gly Glu Glu Cys Gly Val Thr Pro Glu Ser Glu 
465                 470                 475                 480


Asn Leu Thr Leu Ser Ser Ser Gly Ala Ile Asp Gln Ser Ser Cys Thr 
                485                 490                 495


Gly Thr Pro Leu Ser Ser Thr Ile Ser Ser Pro Glu Gly Pro Ala Ser 
            500                 505                 510


Ser Ser Leu Ala Gln Ser Val Met Ser Met Ala Ser Ser Gln Ile Ser 
        515                 520                 525


Thr Asp Thr Val Ser Ser Met Ser Gly Ser Tyr Ile Ala Pro Gly Thr 
    530                 535                 540


Glu Glu Glu Gly Glu Ala Leu Ser Ser Pro Gln Pro Ala Ser Arg Ala 
545                 550                 555                 560


Pro Ser Glu Glu Gly Glu Gly Leu Pro Ala Glu Ser Pro Asp Ser Asn 
                565                 570                 575


Phe Ala Gly Leu Pro Ala Gly Glu Gln Asp Ala Glu Gly Asn Asp Val 
            580                 585                 590


Ile Glu Glu Glu Asp Gly Ser Pro Thr Gln Glu Gly Gln Arg Thr Cys 
        595                 600                 605


Ala Phe Leu Gly Met Glu Cys Asp Asn Asn Asn Asp Phe Asp Ile Ala 
    610                 615                 620


Ser Val Lys Ala Leu Asp Asn Lys Leu Cys Ser Glu Val Cys Leu Pro 
625                 630                 635                 640


Gly Ala Trp Gln Ala Asp Asp Asn Ala Val Ser Arg Asn Ala Gln Arg 
                645                 650                 655


Arg Arg Leu Ser Ser Ser Ser Leu Glu Asp Ser Glu Thr Arg Pro Cys 
            660                 665                 670


Val Trp Gly Pro Leu Ala Val 
        675


<210>  1140
<211>  1440
<212>  DNA
<213>  Homo sapiens

<400>  1140
atttggcatt tctactttgc ctgcccacag atgtagtttt ttccgcacgt gcacgccttc     60

cctcctcccc gccctcaggg tccacggcca ccatggcata ttaggggcag cagtgcctgc    120

ggcagcattg gcctttgcag cggcggcagc agcaccaggc tctgcagcgg caccccccag    180

cggcttaagc catggcgctt cccacggcat tcagcagcag cattgctgta accgacaaag    240

acaccttcga attaagcaca ttactcgatt ccagcaaagc accgcaacat gaccgaaatg    300

agcttcctga gcaacgaggt gttggtgggg gacttgatgt cccccttcga ccagtcgggt    360

ttgggggctg aagaaagcat aggtctctta gatgactacg tggaggtggc caagcacttc    420

aaacctcatg ggttctccag cgacaaggct aaggcgggct cctccgaatg gctgactgtg    480

gatgggttgg tcagtccctc caacaacagc aaggaggatg ccttctctgg gacacattgg    540

atgttggaga aaatggattt gaaggagttc gactttggtg ccctgttggg tatagatgac    600

ctggaaacca tgccagatga ccttttgacc acgttggatg acacttgtaa tctctttgcc    660

cccctagtcc aggagactaa taaggtgccc ccccagatgg tgaacccaat tggccatctc    720

ccagaaagtt taacaaaacc cgaccaggtt gcccccttca ccttcttgca acttcttccc    780

ctttccccag gggtccagtc ctccactcca gatcattcct ttagtttaga gctgggcagt    840

gaagtggata tcactgaaga agataggaag ccggactcca ctgcttacgt tgccatgatc    900

cctcagtgca taaaggagga agacacccct tcagataatg atagtggcat ctgtatgagc    960

ccagagtcct atctggggtc tcctcagcat agcccctcta ccaggggctc tccaaatagg   1020

agcctcccat ctccaggtgt tctctgtggg tctgcccacc ccaaacctta cgatcctcct   1080

ggagagaaga tggtagcagc aaaagtaaag ggtgagaaac tggataagaa gctgaaaaaa   1140

atggagcaaa acaagacagc agccactagg taccgccaga agaagagggc ggagcaggag   1200

gctctcactg gcgagtgcaa agagctggaa aagaagaacg aggctctaaa agagagggca   1260

gattccctgg ccaaggagat ccagtacctg aaagatttga tagaagaggt ccgcaaggca   1320

agggggaaga aaagggtccc ctagttgagg gtaggtcagg agtgtcaacg tgcttgtaca   1380

tagagtgtct gctgtagctg tgtgttccaa taaattattt tgtagggaaa aaaatacata   1440


<210>  1141
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  1141

Met Thr Glu Met Ser Phe Leu Ser Asn Glu Val Leu Val Gly Asp Leu 
1               5                   10                  15


Met Ser Pro Phe Asp Gln Ser Gly Leu Gly Ala Glu Glu Ser Ile Gly 
            20                  25                  30


Leu Leu Asp Asp Tyr Val Glu Val Ala Lys His Phe Lys Pro His Gly 
        35                  40                  45


Phe Ser Ser Asp Lys Ala Lys Ala Gly Ser Ser Glu Trp Leu Thr Val 
    50                  55                  60


Asp Gly Leu Val Ser Pro Ser Asn Asn Ser Lys Glu Asp Ala Phe Ser 
65                  70                  75                  80


Gly Thr His Trp Met Leu Glu Lys Met Asp Leu Lys Glu Phe Asp Phe 
                85                  90                  95


Gly Ala Leu Leu Gly Ile Asp Asp Leu Glu Thr Met Pro Asp Asp Leu 
            100                 105                 110


Leu Thr Thr Leu Asp Asp Thr Cys Asn Leu Phe Ala Pro Leu Val Gln 
        115                 120                 125


Glu Thr Asn Lys Val Pro Pro Gln Met Val Asn Pro Ile Gly His Leu 
    130                 135                 140


Pro Glu Ser Leu Thr Lys Pro Asp Gln Val Ala Pro Phe Thr Phe Leu 
145                 150                 155                 160


Gln Leu Leu Pro Leu Ser Pro Gly Val Gln Ser Ser Thr Pro Asp His 
                165                 170                 175


Ser Phe Ser Leu Glu Leu Gly Ser Glu Val Asp Ile Thr Glu Glu Asp 
            180                 185                 190


Arg Lys Pro Asp Ser Thr Ala Tyr Val Ala Met Ile Pro Gln Cys Ile 
        195                 200                 205


Lys Glu Glu Asp Thr Pro Ser Asp Asn Asp Ser Gly Ile Cys Met Ser 
    210                 215                 220


Pro Glu Ser Tyr Leu Gly Ser Pro Gln His Ser Pro Ser Thr Arg Gly 
225                 230                 235                 240


Ser Pro Asn Arg Ser Leu Pro Ser Pro Gly Val Leu Cys Gly Ser Ala 
                245                 250                 255


His Pro Lys Pro Tyr Asp Pro Pro Gly Glu Lys Met Val Ala Ala Lys 
            260                 265                 270


Val Lys Gly Glu Lys Leu Asp Lys Lys Leu Lys Lys Met Glu Gln Asn 
        275                 280                 285


Lys Thr Ala Ala Thr Arg Tyr Arg Gln Lys Lys Arg Ala Glu Gln Glu 
    290                 295                 300


Ala Leu Thr Gly Glu Cys Lys Glu Leu Glu Lys Lys Asn Glu Ala Leu 
305                 310                 315                 320


Lys Glu Arg Ala Asp Ser Leu Ala Lys Glu Ile Gln Tyr Leu Lys Asp 
                325                 330                 335


Leu Ile Glu Glu Val Arg Lys Ala Arg Gly Lys Lys Arg Val Pro 
            340                 345                 350


<210>  1142
<211>  959
<212>  DNA
<213>  Homo sapiens

<400>  1142
ctctttccca tcttgcaaga tggcaggtga aaaagttgag aagccagata ctaaagagaa     60

gaaacccgaa gccaagaagg ttgatgctgg tggcaaggtg aaaaagggta acctcaaagc    120

taaaaagccc aagaagggga agccccattg cagccgcaac cctgtccttg tcagaggaat    180

tggcaggtat tcccgatctg ccatgtattc cagaaaggcc atgtagaaga ggaagtactc    240

agccgctaaa tccaaggttg aaaagaaaaa gaaggagaag gttcttgcag ctgttacaaa    300

accagttggt ggtgacaaga acggcggtac ccgggtggtt aaacttcgca aaatgcctag    360

atagtatcct actgaagatg tgcctcgaaa gctgttgagc cacggcaaaa aacccttcag    420

tcagcacgtg agaaaactgc gagccagcat tacccccggg accattctga tcatcctcac    480

tggacgccac aggggcaaga gggtggtttt cctgaagcag ctggctagtg gcttattact    540

tgtgactgga cctctggtcc tcaatcgagt tcctctacga agaacacacc agaaatttgt    600

cattgccacc tcaaccaaaa tcgatatcag caatgtaaaa atcccaaaac atcttactga    660

tgcttacttc aagaagaaga agctgcggaa gcccagacac caggaaggtg agatcttcga    720

cacagaaaaa gagaaatatg agattacgga gcagcgcaag attgatcaga aagctgtgga    780

ctcacaaatt ttaccaaaaa tcaaagctat tcctcagctc cagggctacc tgcgatctgt    840

gtttgctctg acgaatggaa tttatcctca caaattggtg ttctaaatgt cttaagaacc    900

taattaaata gctgactaca aaaaaaaaaa aaaaaaaaaa aagacactga caggattga     959


<210>  1143
<211>  7109
<212>  DNA
<213>  Homo sapiens

<400>  1143
attaattgtg gctggacgca gtggcgcggc agtttaattc tccggcggct gcagattgac     60

gggacgagat ggtcctggca gggctcatca ggaaactcgg tcatcagctg gccgagatca    120

gggagcgcgc tctcaagagt attctctgca agattgagca caacttaatc tgctacgctg    180

atctcattca ggagaggcaa ctttttcttc atttgctgga atggttcaat ttcccgtccg    240

ttccgatgaa ggaagaggtt ctgaacctgt taagcagatt ggttaagtat cccccagcag    300

tccaacattt ggttgacgtt ggtgcagtag agttcttatc taagcttcgg tctaatgtgg    360

agccaaatct gcaggctgaa attgatggca ttctggatgg actttttctt cttccttcgg    420

aagttcctgc actatcttct gcctcatacc aaaccaatca aactgaattg tcaaaaaacc    480

ctgaaatctt aacaggatat tttccccaag acaaaagtaa tttccagcag atggaagtgc    540

cgccacgacc agtggtaaat cagactgtga agtgcttgaa gttttctaca tttccttggc    600

tacccctgac caccacagac agacatgtcc tctcctctaa tgaaagctct ttaagaagta    660

gtaaccacac tttaatctgg aacacctgtg aactattgaa ggatgttatc atgcaagatt    720

ttcctgctga gattttcctt caaaggccaa aaattgttca gagcctttta tctctgttga    780

aactggcctt tggagatgga aagcatcgcc tggcattaca gtcggtgtcc tgcctgcagc    840

agctgtgcat gtatttaaga aacagactta actttcaccg agatccaggt tttttctcca    900

ataaacacga cacagtttcc caaaattctt ctttgtctta ttgtcatgaa gcaagaggta    960

ctcatcattc ccagaatcct tccccaggaa gcagcagccc tcggccttct gtggttgggc   1020

gcacaggcca gcgacccaga ggagatggcc aggactggga tgcagcgtcc tctagtggaa   1080

gtagtagtca tgctcatgta aactccagga tatccgttca ttcacctttg gatatgggac   1140

acatagatct gccagagctg gaaactgaag acacattgga actacaattc cagcagctca   1200

gtcttcccca gttttgtgtc tccattctgg aatcagctgt tcctctctta agaacaggta   1260

gcagacaagt gataataaga gttctggaat tgcttacaga ggatatgaca cttattggtg   1320

aagcaatttc aacagatatc tgggatgaca gcagcctttt tggtatagat atgaaggaga   1380

aactactcct ggtgttggga gcccttggag aaaccatgtg ctaccataaa agtagtatca   1440

gtttggagca gccagaggtg atgcttgtgc accacagaat ggcctttatc agcatttccc   1500

tgtttgcagt tcgactgcta caaacgcttc tccctgttga aaaggcaagc gagtttttat   1560

cagagcctat gtcaacagca ttatttctcc tttctttgga catgcctatt tctttggaat   1620

atccaaatat tcatgaagct gttgtggcct atttggaaca gctgaattct gaaaactaca   1680

gtatttataa acgaactgca gaggccgttt attcaattga atgcacctgt aacttcctgt   1740

ctgatattgg gaaagaggga gagaagaatc tcttagaatt agtggagctg gcagaccaag   1800

ccttgcgtag cttttcctat catcagcatt tcccgctaat aaaggaaatc atcagcattt   1860

gttcaaagat ctggaaatct gctcaggcca gtccattact acaaggagaa agtcagaagg   1920

tgcttctcca tatgttgtct cacccattgc cacgagtgaa agctgaaact taccactgct   1980

gtctggaaat cacgaaggaa tgtttaggtg tccataatgt cactaaaccc gtgtcttcac   2040

tttgcaatgg aattcatttt ctacttcatc caaaagttct gtatgaaatc tctgtatttg   2100

gcattcaaga gcccgaaagt gaggtgaaca ctgctgccaa ggccattctg ttatacctgc   2160

ttcagggacg attgatgatg acagcattga cctggaacaa gtttattgaa tctctctgtc   2220

ctgtcatccc aatactacag ggctatgccg acacagaaga tcctctgggt aactgcattc   2280

tccttctaag caaagcaagt tctgacacag aagagatgct tccgtgtact acccgattaa   2340

agtccatgct gcgacttttg ctagtgaaaa agccatcggt ccgttcgcta gcattaaagc   2400

ttttagcatt ccatcttacc agtgaagaag gggctgatac aaagcgtcct ctaatagacg   2460

ccagagttct ctccagagtt actgatttat tcattgggaa gaaacctatt gaactcagac   2520

tggatgacag aagagagctg gttattaagt tggagactgt tgaaaaggta tatgaaatct   2580

tcacctcaga tgatgttgat ctcgttttga gaaagtcagc tgctgaacag ttagctgtga   2640

ttatgcaaga tattaaaatg catgctgtgg tgaaaaagtt atgcttaatt gacaaaataa   2700

ttgagtattt aaatgaatgt gtgagtcaag atggcaaggt tgtagaatgt ttggtacaac   2760

catgcctcac actcttgagg aaggttttat gtggtgatcc agtcatgcgt gtttcgctct   2820

cgcaacagtc ttctcttttg accgtgttat tcagagtttc cttaatattt catgaagatt   2880

gtagtgtcgt gactgaagtt ggagcactat tttgtcttct attatttgat gaagtatcga   2940

gaatggatat gtggtctgtt aatccttcca ataaaccttc tttgccatcg gtcttcagtt   3000

tgcctgtttc cgtttttaga aggtaccatc tacctgttca tgtaattgga caccatgctg   3060

tgagtcctta ctccatagtt ttgcccttat ctgctgattg tttggccttg aagccggtgt   3120

cagatatgct gagaatagct tggaacctgt catggtatca tgggagtgat aatctgttga   3180

agcaaatgaa ctctgaaact aaaacgcaag aaattttaga tgcattgaag ttatctacag   3240

aggacatcct cactctgaag ataacacaca tggctagtgg gctgcaggac tgcctccatt   3300

ccattgttca ggctgcaacc cacagggaag ttagggctgc tgtcaccagg atgagttttt   3360

atcttctgaa tgacagattg tctttaaagg gttgccctgg tccatgtggg gttaccttga   3420

agtccttggc ttggcacacc gcactaaaca ggtttttaca ggtgcttcct gcttgcactg   3480

aagatgagaa actgctaata gatatcatac attttttaaa taaattaata aaggaacaaa   3540

gaaaaaattc ttcactagaa cttctaaact ggattctcga attacttctt agacatagtg   3600

caaacccact gttagacctc ttggttctga cagagtcaca ggcacgagaa gaaacagatg   3660

atatccggac tgctgtcagg caacaacttc agaaagaact gattgctctt tttgatacct   3720

tgctgctcaa tttcatggaa gttactgaca ggaaatgctc ggaacttctt tacgtttttc   3780

aaacgcagct ggctctgaaa ctgctccagt gtctgaaagt gacggatgcg cctcatttct   3840

atggcctgcc gtcccttgag cggaccttac gagggatggc taacctcact gcgtttccgg   3900

gatggagctc acactctcct ctcacaaagc ctctagatat ctgtgtgaag tacttgtcag   3960

gtctccttga ggtcattact tctttttatg tggagcgtgg aggaaatgct atgtccttca   4020

tgggaaaagg tgttacaaag agcacaattc tttgcttgct tcacttatcc catgagatga   4080

tggcccaggc tgggagcttg gagtggatgt cactttggtt cttgcctttg ggtagtcata   4140

gtgaagaaca tattcctact caacaaggat tggcttggtt gattccatta tgggttgatc   4200

gggacccaga ggtgagattc acttcactgg gattaggatc agcactgacc acccttgaaa   4260

cgggctgtgt ggccttagca aacagttgtc agaacatttc cggtgggctc tggggaactg   4320

tggtgaacat tcttctggac cagtcagaat gtagtatggt gcgccgggag gcggcattta   4380

ttcttcagaa tctccttgta attccaatgc ctacagaaat tataaaggat tatacttggc   4440

agggtccctg tgttcatgat gaggactctg gcctatcgct cattggaaaa cctgcccttc   4500

aggctctttt atatcactgc catttttatg aacatttgaa tcagatggta aagcattgtt   4560

acctaggacg gtgtatgttt gatttgaatt tttctgcttt tgatagaaat tcagaaagca   4620

atgatttaaa tggtttagat gactcattca agttttggag ggctccatct aggacaagtc   4680

aggatcgaga tccaagttct ctctccacct cagaaacaac ggtggcacct tcattgggga   4740

gtactgaatt tcagccactt gtgcagtcaa caacacttct acctgaagcc tcccatgacc   4800

agtttgtggc tcaaggtcac caggaaagta catcaccacg gccacctcat gattcatctc   4860

tttctgctcc cctgcccaaa ctgtgtgttt ttgttactcc atctcttctt tcagcaatgt   4920

gcagcctctt ggacaacctc ttgacgattg ctcccagaga cactgcaaag gcttttcgac   4980

aagctcatct catagaactt ctctgtagca ttgcagatgc taccctcata cagacatgtg   5040

tccaggaact cagagccctg ctgccttcat cacctccagc tgaacacact caggctcagg   5100

tttcctttct cctggaatac ctatcctctt tgtccaggct tctgcagtca tgtttattgg   5160

tggagcctga ccttgtgatt caggatgagc ttgtgaaacc tcttatcacc aatatcattg   5220

gaattctcac catatgtacc aaagatgtat tagataaaga gttaatatca gctttttatc   5280

acacatggac acatttattt aatcttctgg ccatgctcct gaggaaagct ggtgccatca   5340

cactcccgtt tgttaccgtg gccctggcca agcactggac agcggcgatt gatatgttct   5400

gcacatgtgc aggcttgtct gccacgtgtc ctgccctgta tactgccagc ttgcaattcc   5460

tttctgttct cttgaccgaa gaagcaaaag ggcatctcca ggctaagagc aaaacacatt   5520

tatgctgtag tccaacagtg gcttcacttc ttgatgactc tcaggaaaat cagaaatctc   5580

tagaacaact tagtgatgta atccttcagt gctatgaagg gaaatcctcc aaagatatcc   5640

tgaaaagagt agctgcaaat gcattgatgt cactgctggc tgtcagtaga agagcacaga   5700

aacatgcttt gaaagccaat cttatagaca attgcatgga gcagatgaaa cacataaatg   5760

cacaactgaa cctagattct ctgaggcctg ggaaagcagc attgaaaaaa aaggaggatg   5820

gtgttattaa agagttaagc attgccatgc agctcctaag aaactgtctt tatcaaaatg   5880

aggaatgtaa agaagcagct cttgaagctc accttgtccc tgtcttgcac tctctctggc   5940

cttggatttt gatggatgat tcattgatgc aaatttctct gcagctcctt tgtgtctata   6000

ctgcaaattt tccaaatggt tgcagttctc tttgttggtc aagttgtgga caacaccctg   6060

ttcaagctac acatagagga gccgtgagca actctctgat gctgtgtatc ctaaagttgg   6120

cttcccagat gccactggag aacaccacgg ttcagcagat ggtttttatg cttctttcaa   6180

acctggcctt gtcgcatgac tgtaaaggag taattcagaa gagtaacttc ttacagaact   6240

tcctctctct agcattgcca aaaggaggaa ataaacatct aagtaatctg actattcttt   6300

ggttgaagtt actcctgaat atatcatctg gagaagatgg gcaacaaatg attctgaggc   6360

ttgatggctg tctagactta ctaacagaga tgagcaaata caagcacaag agcagccctt   6420

tattgcctct tcttatcttt cataatgttt gcttcagtcc tgcaaataaa cccaagatcc   6480

tggctaatga aaaagtcatt actgtgcttg ctgcctgtct ggaaagtgag aatcaaaatg   6540

ctcagaggat tggagcagct gccctttggg ctctgattta caattatcag aaggcaaaaa   6600

cagctttgaa aagcccatca gtaaaaagaa gagtggatga agcatactcc ttagcaaaga   6660

aaactttccc aaactcagaa gcaaaccctc taaatgccta ttatttgaaa tgtcttgaaa   6720

acctcgtgca gctccttaat tcttcctgag tgccatggga tgctacacct tgaagctgac   6780

agtcatcaac aggggagcta aagttgaagc cagctgtgtg tagcagctgt tacctgaaga   6840

cgtgctacct ctctacaaag tgttgatccc cttctttccc atgagagaga gaactggtga   6900

tactccaaca ccgtccagtt gtggcagctc tccagaagta atagcagctg acaactttct   6960

gtgccttttc ctttctgttg aaaaggcata gaaagttctg ggaacataaa catttttacc   7020

cttttctatg ccatttattt tgtaaaaatc ctatttaaca gttatttaat aaaacaatat   7080

ttttagaaac taaaaaaaaa aaaaaaaaa                                     7109


<210>  1144
<211>  2226
<212>  PRT
<213>  Homo sapiens

<400>  1144

Met Val Leu Ala Gly Leu Ile Arg Lys Leu Gly His Gln Leu Ala Glu 
1               5                   10                  15


Ile Arg Glu Arg Ala Leu Lys Ser Ile Leu Cys Lys Ile Glu His Asn 
            20                  25                  30


Leu Ile Cys Tyr Ala Asp Leu Ile Gln Glu Arg Gln Leu Phe Leu His 
        35                  40                  45


Leu Leu Glu Trp Phe Asn Phe Pro Ser Val Pro Met Lys Glu Glu Val 
    50                  55                  60


Leu Asn Leu Leu Ser Arg Leu Val Lys Tyr Pro Pro Ala Val Gln His 
65                  70                  75                  80


Leu Val Asp Val Gly Ala Val Glu Phe Leu Ser Lys Leu Arg Ser Asn 
                85                  90                  95


Val Glu Pro Asn Leu Gln Ala Glu Ile Asp Gly Ile Leu Asp Gly Leu 
            100                 105                 110


Phe Leu Leu Pro Ser Glu Val Pro Ala Leu Ser Ser Ala Ser Tyr Gln 
        115                 120                 125


Thr Asn Gln Thr Glu Leu Ser Lys Asn Pro Glu Ile Leu Thr Gly Tyr 
    130                 135                 140


Phe Pro Gln Asp Lys Ser Asn Phe Gln Gln Met Glu Val Pro Pro Arg 
145                 150                 155                 160


Pro Val Val Asn Gln Thr Val Lys Cys Leu Lys Phe Ser Thr Phe Pro 
                165                 170                 175


Trp Leu Pro Leu Thr Thr Thr Asp Arg His Val Leu Ser Ser Asn Glu 
            180                 185                 190


Ser Ser Leu Arg Ser Ser Asn His Thr Leu Ile Trp Asn Thr Cys Glu 
        195                 200                 205


Leu Leu Lys Asp Val Ile Met Gln Asp Phe Pro Ala Glu Ile Phe Leu 
    210                 215                 220


Gln Arg Pro Lys Ile Val Gln Ser Leu Leu Ser Leu Leu Lys Leu Ala 
225                 230                 235                 240


Phe Gly Asp Gly Lys His Arg Leu Ala Leu Gln Ser Val Ser Cys Leu 
                245                 250                 255


Gln Gln Leu Cys Met Tyr Leu Arg Asn Arg Leu Asn Phe His Arg Asp 
            260                 265                 270


Pro Gly Phe Phe Ser Asn Lys His Asp Thr Val Ser Gln Asn Ser Ser 
        275                 280                 285


Leu Ser Tyr Cys His Glu Ala Arg Gly Thr His His Ser Gln Asn Pro 
    290                 295                 300


Ser Pro Gly Ser Ser Ser Pro Arg Pro Ser Val Val Gly Arg Thr Gly 
305                 310                 315                 320


Gln Arg Pro Arg Gly Asp Gly Gln Asp Trp Asp Ala Ala Ser Ser Ser 
                325                 330                 335


Gly Ser Ser Ser His Ala His Val Asn Ser Arg Ile Ser Val His Ser 
            340                 345                 350


Pro Leu Asp Met Gly His Ile Asp Leu Pro Glu Leu Glu Thr Glu Asp 
        355                 360                 365


Thr Leu Glu Leu Gln Phe Gln Gln Leu Ser Leu Pro Gln Phe Cys Val 
    370                 375                 380


Ser Ile Leu Glu Ser Ala Val Pro Leu Leu Arg Thr Gly Ser Arg Gln 
385                 390                 395                 400


Val Ile Ile Arg Val Leu Glu Leu Leu Thr Glu Asp Met Thr Leu Ile 
                405                 410                 415


Gly Glu Ala Ile Ser Thr Asp Ile Trp Asp Asp Ser Ser Leu Phe Gly 
            420                 425                 430


Ile Asp Met Lys Glu Lys Leu Leu Leu Val Leu Gly Ala Leu Gly Glu 
        435                 440                 445


Thr Met Cys Tyr His Lys Ser Ser Ile Ser Leu Glu Gln Pro Glu Val 
    450                 455                 460


Met Leu Val His His Arg Met Ala Phe Ile Ser Ile Ser Leu Phe Ala 
465                 470                 475                 480


Val Arg Leu Leu Gln Thr Leu Leu Pro Val Glu Lys Ala Ser Glu Phe 
                485                 490                 495


Leu Ser Glu Pro Met Ser Thr Ala Leu Phe Leu Leu Ser Leu Asp Met 
            500                 505                 510


Pro Ile Ser Leu Glu Tyr Pro Asn Ile His Glu Ala Val Val Ala Tyr 
        515                 520                 525


Leu Glu Gln Leu Asn Ser Glu Asn Tyr Ser Ile Tyr Lys Arg Thr Ala 
    530                 535                 540


Glu Ala Val Tyr Ser Ile Glu Cys Thr Cys Asn Phe Leu Ser Asp Ile 
545                 550                 555                 560


Gly Lys Glu Gly Glu Lys Asn Leu Leu Glu Leu Val Glu Leu Ala Asp 
                565                 570                 575


Gln Ala Leu Arg Ser Phe Ser Tyr His Gln His Phe Pro Leu Ile Lys 
            580                 585                 590


Glu Ile Ile Ser Ile Cys Ser Lys Ile Trp Lys Ser Ala Gln Ala Ser 
        595                 600                 605


Pro Leu Leu Gln Gly Glu Ser Gln Lys Val Leu Leu His Met Leu Ser 
    610                 615                 620


His Pro Leu Pro Arg Val Lys Ala Glu Thr Tyr His Cys Cys Leu Glu 
625                 630                 635                 640


Ile Thr Lys Glu Cys Leu Gly Val His Asn Val Thr Lys Pro Val Ser 
                645                 650                 655


Ser Leu Cys Asn Gly Ile His Phe Leu Leu His Pro Lys Val Leu Tyr 
            660                 665                 670


Glu Ile Ser Val Phe Gly Ile Gln Glu Pro Glu Ser Glu Val Asn Thr 
        675                 680                 685


Ala Ala Lys Ala Ile Leu Leu Tyr Leu Leu Gln Gly Arg Leu Met Met 
    690                 695                 700


Thr Ala Leu Thr Trp Asn Lys Phe Ile Glu Ser Leu Cys Pro Val Ile 
705                 710                 715                 720


Pro Ile Leu Gln Gly Tyr Ala Asp Thr Glu Asp Pro Leu Gly Asn Cys 
                725                 730                 735


Ile Leu Leu Leu Ser Lys Ala Ser Ser Asp Thr Glu Glu Met Leu Pro 
            740                 745                 750


Cys Thr Thr Arg Leu Lys Ser Met Leu Arg Leu Leu Leu Val Lys Lys 
        755                 760                 765


Pro Ser Val Arg Ser Leu Ala Leu Lys Leu Leu Ala Phe His Leu Thr 
    770                 775                 780


Ser Glu Glu Gly Ala Asp Thr Lys Arg Pro Leu Ile Asp Ala Arg Val 
785                 790                 795                 800


Leu Ser Arg Val Thr Asp Leu Phe Ile Gly Lys Lys Pro Ile Glu Leu 
                805                 810                 815


Arg Leu Asp Asp Arg Arg Glu Leu Val Ile Lys Leu Glu Thr Val Glu 
            820                 825                 830


Lys Val Tyr Glu Ile Phe Thr Ser Asp Asp Val Asp Leu Val Leu Arg 
        835                 840                 845


Lys Ser Ala Ala Glu Gln Leu Ala Val Ile Met Gln Asp Ile Lys Met 
    850                 855                 860


His Ala Val Val Lys Lys Leu Cys Leu Ile Asp Lys Ile Ile Glu Tyr 
865                 870                 875                 880


Leu Asn Glu Cys Val Ser Gln Asp Gly Lys Val Val Glu Cys Leu Val 
                885                 890                 895


Gln Pro Cys Leu Thr Leu Leu Arg Lys Val Leu Cys Gly Asp Pro Val 
            900                 905                 910


Met Arg Val Ser Leu Ser Gln Gln Ser Ser Leu Leu Thr Val Leu Phe 
        915                 920                 925


Arg Val Ser Leu Ile Phe His Glu Asp Cys Ser Val Val Thr Glu Val 
    930                 935                 940


Gly Ala Leu Phe Cys Leu Leu Leu Phe Asp Glu Val Ser Arg Met Asp 
945                 950                 955                 960


Met Trp Ser Val Asn Pro Ser Asn Lys Pro Ser Leu Pro Ser Val Phe 
                965                 970                 975


Ser Leu Pro Val Ser Val Phe Arg Arg Tyr His Leu Pro Val His Val 
            980                 985                 990


Ile Gly His His Ala Val Ser Pro Tyr Ser Ile Val Leu Pro Leu Ser 
        995                 1000                1005


Ala Asp Cys Leu Ala Leu Lys Pro Val Ser Asp Met Leu Arg Ile Ala 
    1010                1015                1020


Trp Asn Leu Ser Trp Tyr His Gly Ser Asp Asn Leu Leu Lys Gln Met 
1025                1030                1035                1040


Asn Ser Glu Thr Lys Thr Gln Glu Ile Leu Asp Ala Leu Lys Leu Ser 
                1045                1050                1055


Thr Glu Asp Ile Leu Thr Leu Lys Ile Thr His Met Ala Ser Gly Leu 
            1060                1065                1070


Gln Asp Cys Leu His Ser Ile Val Gln Ala Ala Thr His Arg Glu Val 
        1075                1080                1085


Arg Ala Ala Val Thr Arg Met Ser Phe Tyr Leu Leu Asn Asp Arg Leu 
    1090                1095                1100


Ser Leu Lys Gly Cys Pro Gly Pro Cys Gly Val Thr Leu Lys Ser Leu 
1105                1110                1115                1120


Ala Trp His Thr Ala Leu Asn Arg Phe Leu Gln Val Leu Pro Ala Cys 
                1125                1130                1135


Thr Glu Asp Glu Lys Leu Leu Ile Asp Ile Ile His Phe Leu Asn Lys 
            1140                1145                1150


Leu Ile Lys Glu Gln Arg Lys Asn Ser Ser Leu Glu Leu Leu Asn Trp 
        1155                1160                1165


Ile Leu Glu Leu Leu Leu Arg His Ser Ala Asn Pro Leu Leu Asp Leu 
    1170                1175                1180


Leu Val Leu Thr Glu Ser Gln Ala Arg Glu Glu Thr Asp Asp Ile Arg 
1185                1190                1195                1200


Thr Ala Val Arg Gln Gln Leu Gln Lys Glu Leu Ile Ala Leu Phe Asp 
                1205                1210                1215


Thr Leu Leu Leu Asn Phe Met Glu Val Thr Asp Arg Lys Cys Ser Glu 
            1220                1225                1230


Leu Leu Tyr Val Phe Gln Thr Gln Leu Ala Leu Lys Leu Leu Gln Cys 
        1235                1240                1245


Leu Lys Val Thr Asp Ala Pro His Phe Tyr Gly Leu Pro Ser Leu Glu 
    1250                1255                1260


Arg Thr Leu Arg Gly Met Ala Asn Leu Thr Ala Phe Pro Gly Trp Ser 
1265                1270                1275                1280


Ser His Ser Pro Leu Thr Lys Pro Leu Asp Ile Cys Val Lys Tyr Leu 
                1285                1290                1295


Ser Gly Leu Leu Glu Val Ile Thr Ser Phe Tyr Val Glu Arg Gly Gly 
            1300                1305                1310


Asn Ala Met Ser Phe Met Gly Lys Gly Val Thr Lys Ser Thr Ile Leu 
        1315                1320                1325


Cys Leu Leu His Leu Ser His Glu Met Met Ala Gln Ala Gly Ser Leu 
    1330                1335                1340


Glu Trp Met Ser Leu Trp Phe Leu Pro Leu Gly Ser His Ser Glu Glu 
1345                1350                1355                1360


His Ile Pro Thr Gln Gln Gly Leu Ala Trp Leu Ile Pro Leu Trp Val 
                1365                1370                1375


Asp Arg Asp Pro Glu Val Arg Phe Thr Ser Leu Gly Leu Gly Ser Ala 
            1380                1385                1390


Leu Thr Thr Leu Glu Thr Gly Cys Val Ala Leu Ala Asn Ser Cys Gln 
        1395                1400                1405


Asn Ile Ser Gly Gly Leu Trp Gly Thr Val Val Asn Ile Leu Leu Asp 
    1410                1415                1420


Gln Ser Glu Cys Ser Met Val Arg Arg Glu Ala Ala Phe Ile Leu Gln 
1425                1430                1435                1440


Asn Leu Leu Val Ile Pro Met Pro Thr Glu Ile Ile Lys Asp Tyr Thr 
                1445                1450                1455


Trp Gln Gly Pro Cys Val His Asp Glu Asp Ser Gly Leu Ser Leu Ile 
            1460                1465                1470


Gly Lys Pro Ala Leu Gln Ala Leu Leu Tyr His Cys His Phe Tyr Glu 
        1475                1480                1485


His Leu Asn Gln Met Val Lys His Cys Tyr Leu Gly Arg Cys Met Phe 
    1490                1495                1500


Asp Leu Asn Phe Ser Ala Phe Asp Arg Asn Ser Glu Ser Asn Asp Leu 
1505                1510                1515                1520


Asn Gly Leu Asp Asp Ser Phe Lys Phe Trp Arg Ala Pro Ser Arg Thr 
                1525                1530                1535


Ser Gln Asp Arg Asp Pro Ser Ser Leu Ser Thr Ser Glu Thr Thr Val 
            1540                1545                1550


Ala Pro Ser Leu Gly Ser Thr Glu Phe Gln Pro Leu Val Gln Ser Thr 
        1555                1560                1565


Thr Leu Leu Pro Glu Ala Ser His Asp Gln Phe Val Ala Gln Gly His 
    1570                1575                1580


Gln Glu Ser Thr Ser Pro Arg Pro Pro His Asp Ser Ser Leu Ser Ala 
1585                1590                1595                1600


Pro Leu Pro Lys Leu Cys Val Phe Val Thr Pro Ser Leu Leu Ser Ala 
                1605                1610                1615


Met Cys Ser Leu Leu Asp Asn Leu Leu Thr Ile Ala Pro Arg Asp Thr 
            1620                1625                1630


Ala Lys Ala Phe Arg Gln Ala His Leu Ile Glu Leu Leu Cys Ser Ile 
        1635                1640                1645


Ala Asp Ala Thr Leu Ile Gln Thr Cys Val Gln Glu Leu Arg Ala Leu 
    1650                1655                1660


Leu Pro Ser Ser Pro Pro Ala Glu His Thr Gln Ala Gln Val Ser Phe 
1665                1670                1675                1680


Leu Leu Glu Tyr Leu Ser Ser Leu Ser Arg Leu Leu Gln Ser Cys Leu 
                1685                1690                1695


Leu Val Glu Pro Asp Leu Val Ile Gln Asp Glu Leu Val Lys Pro Leu 
            1700                1705                1710


Ile Thr Asn Ile Ile Gly Ile Leu Thr Ile Cys Thr Lys Asp Val Leu 
        1715                1720                1725


Asp Lys Glu Leu Ile Ser Ala Phe Tyr His Thr Trp Thr His Leu Phe 
    1730                1735                1740


Asn Leu Leu Ala Met Leu Leu Arg Lys Ala Gly Ala Ile Thr Leu Pro 
1745                1750                1755                1760


Phe Val Thr Val Ala Leu Ala Lys His Trp Thr Ala Ala Ile Asp Met 
                1765                1770                1775


Phe Cys Thr Cys Ala Gly Leu Ser Ala Thr Cys Pro Ala Leu Tyr Thr 
            1780                1785                1790


Ala Ser Leu Gln Phe Leu Ser Val Leu Leu Thr Glu Glu Ala Lys Gly 
        1795                1800                1805


His Leu Gln Ala Lys Ser Lys Thr His Leu Cys Cys Ser Pro Thr Val 
    1810                1815                1820


Ala Ser Leu Leu Asp Asp Ser Gln Glu Asn Gln Lys Ser Leu Glu Gln 
1825                1830                1835                1840


Leu Ser Asp Val Ile Leu Gln Cys Tyr Glu Gly Lys Ser Ser Lys Asp 
                1845                1850                1855


Ile Leu Lys Arg Val Ala Ala Asn Ala Leu Met Ser Leu Leu Ala Val 
            1860                1865                1870


Ser Arg Arg Ala Gln Lys His Ala Leu Lys Ala Asn Leu Ile Asp Asn 
        1875                1880                1885


Cys Met Glu Gln Met Lys His Ile Asn Ala Gln Leu Asn Leu Asp Ser 
    1890                1895                1900


Leu Arg Pro Gly Lys Ala Ala Leu Lys Lys Lys Glu Asp Gly Val Ile 
1905                1910                1915                1920


Lys Glu Leu Ser Ile Ala Met Gln Leu Leu Arg Asn Cys Leu Tyr Gln 
                1925                1930                1935


Asn Glu Glu Cys Lys Glu Ala Ala Leu Glu Ala His Leu Val Pro Val 
            1940                1945                1950


Leu His Ser Leu Trp Pro Trp Ile Leu Met Asp Asp Ser Leu Met Gln 
        1955                1960                1965


Ile Ser Leu Gln Leu Leu Cys Val Tyr Thr Ala Asn Phe Pro Asn Gly 
    1970                1975                1980


Cys Ser Ser Leu Cys Trp Ser Ser Cys Gly Gln His Pro Val Gln Ala 
1985                1990                1995                2000


Thr His Arg Gly Ala Val Ser Asn Ser Leu Met Leu Cys Ile Leu Lys 
                2005                2010                2015


Leu Ala Ser Gln Met Pro Leu Glu Asn Thr Thr Val Gln Gln Met Val 
            2020                2025                2030


Phe Met Leu Leu Ser Asn Leu Ala Leu Ser His Asp Cys Lys Gly Val 
        2035                2040                2045


Ile Gln Lys Ser Asn Phe Leu Gln Asn Phe Leu Ser Leu Ala Leu Pro 
    2050                2055                2060


Lys Gly Gly Asn Lys His Leu Ser Asn Leu Thr Ile Leu Trp Leu Lys 
2065                2070                2075                2080


Leu Leu Leu Asn Ile Ser Ser Gly Glu Asp Gly Gln Gln Met Ile Leu 
                2085                2090                2095


Arg Leu Asp Gly Cys Leu Asp Leu Leu Thr Glu Met Ser Lys Tyr Lys 
            2100                2105                2110


His Lys Ser Ser Pro Leu Leu Pro Leu Leu Ile Phe His Asn Val Cys 
        2115                2120                2125


Phe Ser Pro Ala Asn Lys Pro Lys Ile Leu Ala Asn Glu Lys Val Ile 
    2130                2135                2140


Thr Val Leu Ala Ala Cys Leu Glu Ser Glu Asn Gln Asn Ala Gln Arg 
2145                2150                2155                2160


Ile Gly Ala Ala Ala Leu Trp Ala Leu Ile Tyr Asn Tyr Gln Lys Ala 
                2165                2170                2175


Lys Thr Ala Leu Lys Ser Pro Ser Val Lys Arg Arg Val Asp Glu Ala 
            2180                2185                2190


Tyr Ser Leu Ala Lys Lys Thr Phe Pro Asn Ser Glu Ala Asn Pro Leu 
        2195                2200                2205


Asn Ala Tyr Tyr Leu Lys Cys Leu Glu Asn Leu Val Gln Leu Leu Asn 
    2210                2215                2220


Ser Ser 
2225


<210>  1145
<211>  3014
<212>  DNA
<213>  Homo sapiens

<400>  1145
caggtggccc tgaattcatt gcctgctcag caaaataaag gcccagtgtg gaagccggaa     60

cttgcatttg aagaaggatg ggaaggatgg gttgaggagg gcccatcccc agcagcccga    120

gagggaggag gccacggaga cttggagcat tcccgtttct tccagagcgc tgcgggataa    180

aggaggagcg tcctgcttcc cggctgccct gttgctgtcg gagtcacagg atggcggctg    240

tcatcctgcc ctcgactgct gctccgtctt ccctgttccc agcctctcag caaaaaggac    300

acacacaggg cggagagctg gttaatgagc tcctgacaag ctggctacgg ggcttggtaa    360

ccttcgagga tgtggccgtg gagttcaccc aggaggagtg ggcgttgctg gaccctgccc    420

aaaggacact gtacagggat gtgatgctgg agaactgcag gaacctggcc tcactagggt    480

gtcgtgttaa taaacccagt ctgatatccc agttggaaca agacaagaag gtggtgacag    540

aggaaagagg aattctacca agcacctgtc cagatttgga gactctactt aaagccaaat    600

ggttaactcc taagaagaat gttttcagaa aagaacagtc taaaggtgta aaaacggaaa    660

gaagtcatcg tggagtgaaa ctcaatgaat gtaatcagtg ttttaaagtc ttcagcacga    720

aatctaacct aactcagcac aagagaattc atactggaga aaaaccctat gactgtagtc    780

aatgtgggaa gtccttcagt agcagatctt accttactat tcataagaga atccataatg    840

gggagaaacc ctatgaatgc aatcactgtg ggaaagcatt tagtgatccc tcatccctta    900

gactgcattt gagaattcac actggagaaa aaccctatga atgtaaccag tgttttcacg    960

ttttccgcac cagttgtaac ctcaaaagcc acaagaggat tcacacgggg gagaatcacc   1020

atgaatgtaa tcagtgtgga aaagctttca gcacaaggtc ctctctcact gggcacaata   1080

gcattcatac aggggagaaa ccttatgaat gtcacgattg tgggaaaacc ttcaggaaga   1140

gctcctatct gacacagcac gtaagaactc atactggaga aaaaccctat gaatgtaacg   1200

agtgtgggaa atccttcagc agtagctttt ctcttactgt gcacaagaga atacataccg   1260

gagagaaacc ctacgagtgc agtgactgtg gaaaagcctt taataatctc tcagctgtga   1320

agaaacactt aagaactcac actggagaaa aaccctatga atgtaatcat tgtgggaaat   1380

ccttcacaag taactcctat ctttctgtgc acaagagaat acataataga tggatatgaa   1440

ttactgcagg aacttctgga ggaaagcact cattgatctt tcatccctaa gatagtttga   1500

gagagctcac actggatata taagttattt gttgcagcat aacaaatgat ccccgcaaat   1560

tttgtggctt caaacacgaa atgtttattc tctaacaatt tctacagatc aggaattcaa   1620

gaacagctta tctctgtagt tacactgcag gatctctcat gcctttactt acaatcaaga   1680

tgtcagccaa agctatagtc atctaacatc tttactgatg aacagtccac ttccaagatg   1740

acttattcac atgcctggaa agttgatgtt ggttgttgtc aggggacctt cagtcattac   1800

catgtaggcc tctttacaag gcccagctcc ttgacaattt ggcaataagt tctcgccaag   1860

gttagtgatc caagagagga ccaatacaga ggccaaaatg gcttttatgg cctatcctca   1920

ggaggactgc taagctttca cttatttcct attgtgttgg tctcacaaca caccaatcct   1980

gatacaatgt gagagactgc agaaggtatg aataccagga aacagataac tcagaagcat   2040

ctgggaaatt tgccatggaa ttaatgaaga aaagccctca gcacatcatc cttctactct   2100

aatcaatatg aaatagcatt cagtaactcc tattaattca ctctgaagag aaaccttttg   2160

aggacaatct gtatggtaaa gctctcagct cgaattctca ccttcatggg cccagaagat   2220

tatgtactga gagaatcctg aagaatggaa cagctgtaga aagccttcag tgctatcagc   2280

agggattcat gtgacagctc acactaaggg agaaaacctg tgaaggtctc agaaggcttc   2340

agtgacagtc atcccttaag acacactgga aatcacacaa tggaacaaca ctcagaaatg   2400

cggaataccc tgcagcaaaa gtgttcacat tactgagcaa actatagtgt ggtattctgc   2460

agtgactatg ggaaagcctt gaatgttcta tcggttttta agggacttga gaattaattc   2520

tggagagaat gccccattga acatcatcaa tattggagag ctttctgttt ttctacattt   2580

gttaggaaac ttgtgagcat tcacactaca gagaaacttg aaatataaag aagaagagaa   2640

agccttcagt gatgcctctg tgttagggaa aatatggaac ttctccctgg atgcaaaacc   2700

tatgagtata ttaatattgg aaaatttttc agtgattctt ctctttcttg tatatgagag   2760

aacttacatg gagaaacccc taggaatgta atcagtgtta ggatgcctca gcctgaactc   2820

ttcactgagt ggccacaatt ttcactggga acaaaaagta taatcactgt tttgagtgtg   2880

ggatatcctt tatcagtgtc tcatctgtag attggactgc tggctcatta atttttttag   2940

tctttttttc ttttaatata aacatttgtg tatagctgtt ccctaaaata aacattaaca   3000

tatttcataa tttt                                                     3014


<210>  1146
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  1146

Met Ala Ala Val Ile Leu Pro Ser Thr Ala Ala Pro Ser Ser Leu Phe 
1               5                   10                  15


Pro Ala Ser Gln Gln Lys Gly His Thr Gln Gly Gly Glu Leu Val Asn 
            20                  25                  30


Glu Leu Leu Thr Ser Trp Leu Arg Gly Leu Val Thr Phe Glu Asp Val 
        35                  40                  45


Ala Val Glu Phe Thr Gln Glu Glu Trp Ala Leu Leu Asp Pro Ala Gln 
    50                  55                  60


Arg Thr Leu Tyr Arg Asp Val Met Leu Glu Asn Cys Arg Asn Leu Ala 
65                  70                  75                  80


Ser Leu Gly Cys Arg Val Asn Lys Pro Ser Leu Ile Ser Gln Leu Glu 
                85                  90                  95


Gln Asp Lys Lys Val Val Thr Glu Glu Arg Gly Ile Leu Pro Ser Thr 
            100                 105                 110


Cys Pro Asp Leu Glu Thr Leu Leu Lys Ala Lys Trp Leu Thr Pro Lys 
        115                 120                 125


Lys Asn Val Phe Arg Lys Glu Gln Ser Lys Gly Val Lys Thr Glu Arg 
    130                 135                 140


Ser His Arg Gly Val Lys Leu Asn Glu Cys Asn Gln Cys Phe Lys Val 
145                 150                 155                 160


Phe Ser Thr Lys Ser Asn Leu Thr Gln His Lys Arg Ile His Thr Gly 
                165                 170                 175


Glu Lys Pro Tyr Asp Cys Ser Gln Cys Gly Lys Ser Phe Ser Ser Arg 
            180                 185                 190


Ser Tyr Leu Thr Ile His Lys Arg Ile His Asn Gly Glu Lys Pro Tyr 
        195                 200                 205


Glu Cys Asn His Cys Gly Lys Ala Phe Ser Asp Pro Ser Ser Leu Arg 
    210                 215                 220


Leu His Leu Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Gln 
225                 230                 235                 240


Cys Phe His Val Phe Arg Thr Ser Cys Asn Leu Lys Ser His Lys Arg 
                245                 250                 255


Ile His Thr Gly Glu Asn His His Glu Cys Asn Gln Cys Gly Lys Ala 
            260                 265                 270


Phe Ser Thr Arg Ser Ser Leu Thr Gly His Asn Ser Ile His Thr Gly 
        275                 280                 285


Glu Lys Pro Tyr Glu Cys His Asp Cys Gly Lys Thr Phe Arg Lys Ser 
    290                 295                 300


Ser Tyr Leu Thr Gln His Val Arg Thr His Thr Gly Glu Lys Pro Tyr 
305                 310                 315                 320


Glu Cys Asn Glu Cys Gly Lys Ser Phe Ser Ser Ser Phe Ser Leu Thr 
                325                 330                 335


Val His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Asp 
            340                 345                 350


Cys Gly Lys Ala Phe Asn Asn Leu Ser Ala Val Lys Lys His Leu Arg 
        355                 360                 365


Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Asn His Cys Gly Lys Ser 
    370                 375                 380


Phe Thr Ser Asn Ser Tyr Leu Ser Val His Lys Arg Ile His Asn Arg 
385                 390                 395                 400


Trp Ile 



<210>  1147
<211>  664
<212>  DNA
<213>  Homo sapiens

<400>  1147
agtgtaagag gaaaagaagt gtgatggcca agagttcaca gaggaagcaa cgtgactgtg     60

taaaccaatg caaatcaaag cctggcttga gcacctcaat ccctttgaga atgtccagtt    120

acacattcaa gaggccagta acgagaatta caccccatcc tggcaatgag gtcagatacc    180

atcaatggga ggagagcttg gagaagcctc agcaggtctg ctggcagagg agactgcagg    240

gactccaggc ttacagcagt gcaggagaac tttcaagcac tttggatctt gccaatacct    300

tgcaaaaact tgtccctagt tacacaggtg gatctctgct ggaggatctt gccagtggtc    360

tggagcactc ctgccccatg ccccaccttg cctgctcttc agatgcggtg gagataattc    420

ctgcagaggg agtgggtatc tcgcagctcc tctgcaaaca atttctggtc actgaggaag    480

atatcaggaa acaggaaggg aaagtgaaga cagtcagaga gagactcgca atagcactga    540

ttgcggatgg actcgctaat gaggcagaga aagtgagaga ccaagaaggc tgtcctgaaa    600

aacgctaaga aaaaaaggga agatagtgca gatgaaataa agtgtaatcc tttattaaca    660

tctc                                                                 664


<210>  1148
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  1148

Met Ala Lys Ser Ser Gln Arg Lys Gln Arg Asp Cys Val Asn Gln Cys 
1               5                   10                  15


Lys Ser Lys Pro Gly Leu Ser Thr Ser Ile Pro Leu Arg Met Ser Ser 
            20                  25                  30


Tyr Thr Phe Lys Arg Pro Val Thr Arg Ile Thr Pro His Pro Gly Asn 
        35                  40                  45


Glu Val Arg Tyr His Gln Trp Glu Glu Ser Leu Glu Lys Pro Gln Gln 
    50                  55                  60


Val Cys Trp Gln Arg Arg Leu Gln Gly Leu Gln Ala Tyr Ser Ser Ala 
65                  70                  75                  80


Gly Glu Leu Ser Ser Thr Leu Asp Leu Ala Asn Thr Leu Gln Lys Leu 
                85                  90                  95


Val Pro Ser Tyr Thr Gly Gly Ser Leu Leu Glu Asp Leu Ala Ser Gly 
            100                 105                 110


Leu Glu His Ser Cys Pro Met Pro His Leu Ala Cys Ser Ser Asp Ala 
        115                 120                 125


Val Glu Ile Ile Pro Ala Glu Gly Val Gly Ile Ser Gln Leu Leu Cys 
    130                 135                 140


Lys Gln Phe Leu Val Thr Glu Glu Asp Ile Arg Lys Gln Glu Gly Lys 
145                 150                 155                 160


Val Lys Thr Val Arg Glu Arg Leu Ala Ile Ala Leu Ile Ala Asp Gly 
                165                 170                 175


Leu Ala Asn Glu Ala Glu Lys Val Arg Asp Gln Glu Gly Cys Pro Glu 
            180                 185                 190


Lys Arg 



<210>  1149
<211>  43816
<212>  DNA
<213>  Homo sapiens

<400>  1149
aagcgttgca caattccccc aacctccata catacggcag ctcttctaga cacaggtttt     60

cccaggtcaa atgcggggac cccagccata tctcccaccc tgagaaattt tggagtttca    120

gggagctcag aagctctgca gaggccaccc tctctgaggg gattcttctt agacctccat    180

ccagaggcaa atgttgacct gtccatgctg aaaccctcag gccttcctgg gtcatcttct    240

cccacccgct ccttgatgac agggagcagg agcactaaag ccacaccaga aatggattca    300

ggactgacag gagccacctt gtcacctaag acatctacag gtgcaatcgt ggtgacagaa    360

catactctgc cctttacttc cccagataag accttggcca gtcctacatc ttcggttgtg    420

ggaagaacca cccagtcttt gggggtgatg tcctctgctc tccctgagtc aacctctaga    480

ggaatgacac actccgagca aagaaccagc ccatcgctga gtccccaggt caatggaact    540

ccctctagga actaccctgc tacaagcatg gtttcaggat tgagttcccc aaggaccagg    600

accagttcca cagaaggaaa ttttaccaaa gaagcatcta catacacact cactgtagag    660

accacaagtg gcccagtcac tgagaagtac acagtcccca ctgagacctc aacaactgaa    720

ggtgacagca cagagacccc ctgggacaca agatatattc ctgtaaaaat cacatctcca    780

atgaaaacat ttgcagattc aactgcatcc aaggaaaatg ccccagtgtc tatgactcca    840

gctgagacca cagttactga ctcacatact ccaggaagga caaacccatc atttgggaca    900

ctttattctt ccttccttga cctatcacct aaagggaccc caaattccag aggtgaaaca    960

agcctggaac tgattctatc aaccactgga tatcccttct cctctcctga acctggctct   1020

gcaggacaca gcagaataag taccagtgcg cctttgtcat catctgcttc agttctcgat   1080

aataaaatat cagagaccag catattctca ggccagagtc tcacctcccc tctgtctcct   1140

ggggtgcccg aggccagagc cagcacaatg cccaactcag ctatcccttt ttccatgaca   1200

ctaagcaatg cagaaacaag tgccgaaagg gtcagaagca caatttcctc tctggggact   1260

ccatcaatat ccacaaagca gacagcagag actatcctta ccttccatgc cttcgctgag   1320

accatggata tacccagcac ccacatagcc aagactttgg cttcagaatg gttgggaagt   1380

ccaggtaccc ttggtggcac cagcacttca gcgctgacaa ccacatctcc atctaccact   1440

ttagtctcag aggagaccaa cacccatcac tccacgagtg gaaaggaaac agaaggaact   1500

ttgaatacat ctatgactcc acttgagacc tctgctcctg gagaagagtc cgaaatgact   1560

gccaccttgg tccccactct aggttttaca actcttgaca gcaagatcag aagtccatct   1620

caggtctctt catcccaccc aacaagagag ctcagaacca caggcagcac ctctgggagg   1680

cagagttcca gcacagctgc ccacgggagc tctgacatcc tgagggcaac cacttccagc   1740

acctcaaaag catcatcatg gaccagtgaa agcacagctc agcaatttag tgaaccccag   1800

cacacacagt gggtggagac aagtcctagc atgaaaacag agagaccccc agcatcaacc   1860

agtgtggcag cccctatcac cacttctgtt ccctcagtgg tctctggctt caccaccctg   1920

aagaccagct ccacaaaagg gatttggctt gaagaaacat ctgcagacac actcatcgga   1980

gaatccacag ctggcccaac cacccatcag tttgctgttc ccactgggat ttcaatgaca   2040

ggaggcagca gcaccagggg aagccagggc acaacccacc tactcaccag agccacagca   2100

tcatctgaga catccgcaga tttgactctg gccacgaacg gtgtcccagt ctccgtgtct   2160

ccagcagtga gcaagacggc tgctggctca agtcctccag gagggacaaa gccatcatat   2220

acaatggttt cttctgtcat ccctgagaca tcatctctac agtcctcagc tttcagggaa   2280

ggaaccagcc tgggactgac tccattaaac actagacatc ccttctcttc ccctgaacca   2340

gactctgcag gacacaccaa gataagcacc agcattcctc tgttgtcatc tgcttcagtt   2400

cttgaggata aagtgtcagc gaccagcaca ttctcacacc acaaagccac ctcatctatt   2460

accacaggga ctcctgaaat ctcaacaaag acaaagccca gctcagccgt tctttcctcc   2520

atgaccctaa gcaatgcagc aacaagtcct gaaagagtca gaaatgcaac ttcccctctg   2580

actcatccat ctccatcagg ggaagagaca gcagggagtg tcctcactct cagcacctct   2640

gctgagacta cagactcacc taacatccac ccaactggga cactgacttc agaatcgtca   2700

gagagtccta gcactctcag cctcccaagt gtctctggag tcaaaaccac attttcttca   2760

tctactcctt ccactcatct atttactagt ggagaagaaa cagaggaaac ttcgaatcca   2820

tctgtgtctc aacctgagac ttctgtttcc agagtaagga ccaccttggc cagcacctct   2880

gtccctaccc cagtattccc caccatggac acctggccta cacgttcagc tcagttctct   2940

tcatcccacc tagtgagtga gctcagagct acgagcagta cctcagttac aaactcaact   3000

ggttcagctc ttcctaaaat atctcacctc actgggacgg caacaatgtc acagaccaat   3060

agagacacgt ttaatgactc tgctgcaccc caaagcacaa cttggccaga gactagtccc   3120

agattcaaga cagggttacc ttcagcaaca accactgttt caacctctgc cacttctctc   3180

tctgctactg taatggtctc taaattcact tctccagcaa ctagttccat ggaagcaact   3240

tctatcaggg aaccatcaac aaccatcctc acaacagaga ccacgaatgg cccaggctct   3300

atggctgtgg cttctaccaa catcccaatt ggaaagggct acattactga aggaagattg   3360

gacacaagcc atctgcccat tggaaccaca gcttcctctg agacatctat ggattttacc   3420

atggccaaag aaagtgtctc aatgtcagta tctccatctc agtccatgga tgctgctggc   3480

tcaagcactc caggaaggac aagccaattc gttgacacat tttctgatga tgtctatcat   3540

ttaacatcca gagaaattac aatacctaga gatggaacaa gctcagctct gactccacaa   3600

atgactgcaa ctcaccctcc atctcctgat cctggctctg ctagaagcac ctggcttggc   3660

atcttgtcct catctccttc ttctcctact cccaaagtca caatgagctc cacattttca   3720

actcagagag tcaccacaag catgataatg gacacagttg aaactagtcg gtggaacatg   3780

cccaacttac cttccacgac ttccttgaca ccaagtaata ttccaacaag tggtgccata   3840

ggaaaaagca ccctggttcc cttggacact ccatctccag ccacatcatt ggaggcatca   3900

gaagggggac ttccaaccct cagcacctac cctgaatcaa caaacacacc cagcatccac   3960

ctcggagcac acgctagttc agaaagtcca agcaccatca aacttaccat ggcttcagta   4020

gtaaaacctg gctcttacac acctctcacc ttcccctcaa tagagaccca cattcatgta   4080

tcaacagcca gaatggctta ctcttctggg tcttcacctg agatgacagc tcctggagag   4140

actaacactg gtagtacctg ggaccccacc acctacatca ccactacgga tcctaaggat   4200

acaagttcag ctcaggtctc tacaccccac tcagtgagga cactcagaac cacagaaaac   4260

catccaaaga cagagtccgc caccccagct gcttactctg gaagtcctaa aatctcaagt   4320

tcacccaatc tcaccagtcc ggccacaaaa gcatggacca tcacagacac aactgaacac   4380

tccactcaat tacattacac aaaattggca gaaaaatcat ctggatttga gacacagtca   4440

gctccaggac ctgtctctgt agtaatccct acctccccta ccattggaag cagcacattg   4500

gaactaactt ctgatgtccc aggggaaccc ctggtccttg ctcccagtga gcagaccaca   4560

atcactctcc ccatggcaac atggctgagt accagtttga cagaggaaat ggcttcaaca   4620

gaccttgata tttcaagtcc aagttcaccc atgagtacat ttgctatttt tccacctatg   4680

tccacacctt ctcatgaact ttcaaagtca gaggcagata ccagtgccat tagaaataca   4740

gattcaacaa cgttggatca gcacctagga atcaggagtt tgggcagaac tggggactta   4800

acaactgttc ctatcacccc actgacaacc acgtggacca gtgtgattga acactcaaca   4860

caagcacagg acaccctttc tgcaacgatg agtcctactc acgtgacaca gtcactcaaa   4920

gatcaaacat ctataccagc ctcagcatcc ccttcccatc ttactgaagt ctaccctgag   4980

ctcgggacac aagggagaag ctcctctgag gcaaccactt tttggaaacc atctacagac   5040

acactgtcca gagagattga gactggccca acaaacattc aatccactcc acccatggac   5100

aacacaacaa cagggagcag tagtagtgga gtcaccctgg gcatagccca ccttcccata   5160

ggaacatcct ccccagctga gacatccaca aacatggcac tggaaagaag aagttctaca   5220

gccactgtct ctatggctgg gacaatggga ctccttgtta ctagtgctcc aggaagaagc   5280

atcagccagt cattaggaag agtttcctct gtcctttctg agtcaactac tgaaggagtc   5340

acagattcta gtaagggaag cagcccaagg ctgaacacac agggaaatac agctctctcc   5400

tcctctcttg aacccagcta tgctgaagga agccagatga gcacaagcat ccctctaacc   5460

tcatctccta caactcctga tgtggaattc atagggggca gcacattttg gaccaaggag   5520

gtcaccacag ttatgacctc agacatctcc aagtcttcag caaggacaga gtccagctca   5580

gctaccctta tgtccacagc tttgggaagc actgaaaata caggaaaaga aaaactcaga   5640

actgcctcta tggatcttcc atctccaact ccatcaatgg aggtgacacc atggatttct   5700

ctcactctca gtaatgcccc caataccaca gattcacttg acctcagcca tggggtgcac   5760

accagctctg cagggacttt ggccactgac aggtcattga atactggtgt cactagagcc   5820

tccagattgg aaaacggctc tgatacctct tctaagtccc tgtctatggg aaacagcact   5880

cacacttcca tgacttacac agagaagagt gaagtgtctt cttcaatcca tccccgacct   5940

gagacctcag ctcctggagc agagaccact ttgacttcca ctcctggaaa cagggccata   6000

agcttaacat tgcctttttc atccattcca gtggaagaag tcatttctac aggcataacc   6060

tcaggaccag acatcaactc agcacccatg acacattctc ccatcacccc accaacaatt   6120

gtatggacca gtacaggcac aattgaacag tccactcaac cactacatgc agtttcttca   6180

gaaaaagttt ctgtgcagac acagtcaact ccatatgtca actctgtggc agtgtctgct   6240

tcccctaccc atgagaattc agtctcttct ggaagcagca catcctctcc atattcctca   6300

gcctcacttg aatccttgga ttccacaatc agtaggagga atgcaatcac ttcctggcta   6360

tgggacctca ctacatctct ccccactaca acttggccaa gtactagttt atctgaggca   6420

ctgtcctcag gccattctgg ggtttcaaac ccaagttcaa ctacgactga atttccactc   6480

ttttcagctg catccacatc tgctgctaag caaagaaatc cagaaacaga gacccatggt   6540

ccccagaata cagccgcgag tactttgaac actgatgcat cctcggtcac aggtctttct   6600

gagactcctg tgggggcaag tatcagctct gaagtccctc ttccaatggc cataacttct   6660

agatcagatg tttctggcct tacatctgag agtactgcta acccgagttt aggcacagcc   6720

tcttcagcag ggaccaaatt aactaggaca atatccctgc ccacttcaga gtctttggtt   6780

tcctttagaa tgaacaagga tccatggaca gtgtcaatcc ctttggggtc ccatccaact   6840

actaatacag aaacaagcat cccagtaaac agcgcaggtc cacctggctt gtccacagta   6900

gcatcagatg taattgacac accttcagat ggggctgaga gtattcccac tgtctccttt   6960

tccccctccc ctgatactga agtgacaact atctcacatt tcccagaaaa gacaactcat   7020

tcatttagaa ccatttcatc tctcactcat gagttgactt caagagtgac acctattcct   7080

ggggattgga tgagttcagc tatgtctaca aagcccacag gagccagtcc ctccattaca   7140

ctgggagaga gaaggacaat cacctctgct gctccaacca cttcccccat agttctcact   7200

gctagtttca cagagaccag cacagtttca ctggataatg aaactacagt aaaaacctca   7260

gatatccttg acgcacggaa aacaaatgag ctcccctcag atagcagttc ttcttctgat   7320

ctgatcaaca cctccatagc ttcttcaact atggatgtca ctaaaacagc ctccatcagt   7380

cccactagca tctcaggaat gacagcaagt tcctccccat ctctcttctc ttcagataga   7440

ccccaggttc ccacatctac aacagagaca aatacagcca cctctccatc tgtttccagt   7500

aacacctatt ctcttgatgg gggctccaat gtgggtggca ctccatccac tttaccaccc   7560

tttacaatca cccaccctgt cgagacaagc tcggccctat tagcctggtc tagaccagta   7620

agaactttca gcaccatggt cagcactgac actgcctccg gagaaaatcc tacctctagc   7680

aattctgtgg tgacttctgt tccagcacca ggtacatgga ccagtgtagg cagtactact   7740

gacttacctg ccatgggctt tctcaagaca agtcctgcag gagaggcaca ctcacttcta   7800

gcatcaacta ttgaaccagc cactgccttc actccccatc tctcagcagc agtggtcact   7860

ggatccagtg ctacatcaga agccagtctt ctcactacga gtgaaagcaa agccattcat   7920

tcttcaccac agaccccaac tacacccacc tctggagcaa actgggaaac ttcagctact   7980

cctgagagcc ttttggtagt cactgagact tcagacacaa cacttacctc aaagattttg   8040

gtcacagata ccatcttgtt ttcaactgtg tccacgccac cttctaaatt tccaagtacg   8100

gggactctgt ctggagcttc cttccctact ttactcccgg acactccagc catccctctc   8160

actgccactg agccaacaag ttcattagct acatcctttg attccacccc actggtgact   8220

atagcttcgg atagtcttgg cacagtccca gagactaccc tgaccatgtc agagacctca   8280

aatggtgatg cactggttct taagacagta agtaacccag ataggagcat ccctggaatc   8340

actatccaag gagtaacaga aagtccactc catccttctt ccacttcccc ctctaagatt   8400

gttgctccac ggaatacaac ctatgaaggt tcgatcacag tggcactttc tactttgcct   8460

gcgggaacta ctggttccct tgtattcagt cagagttctg aaaactcaga gacaacggct   8520

ttggtagact catcagctgg gcttgagagg gcatctgtga tgccactaac cacaggaagc   8580

cagggtatgg ctagctctgg aggaatcaga agtgggtcca ctcactcaac tggaaccaaa   8640

acattttctt ctctccctct gaccatgaac ccaggtgagg ttacagccat gtctgaaatc   8700

accacgaaca gactgacagc tactcaatca acagcaccca aagggatacc tgtgaagccc   8760

accagtgctg agtcaggcct cctaacacct gtctctgcct cctcaagccc atcaaaggcc   8820

tttgcctcac tgactacagc tcccccaact tgggggatcc cacagtctac cttgacattt   8880

gagttttctg aggtcccaag tttggatact aagtccgctt ctttaccaac tcctggacag   8940

tccctgaaca ccattccaga ctcagatgca agcacagcat cttcctcact gtccaagtct   9000

ccagaaaaaa acccaagggc aaggatgatg acttccacaa aggccataag tgcaagctca   9060

tttcaatcaa caggttttac tgaaacccct gagggatctg cctccccttc tatggcaggg   9120

catgaaccca gagtccccac ttcaggaaca ggggacccta gatatgcctc agagagcatg   9180

tcttatccag acccaagcaa ggcatcatca gctatgacat cgacctctct tgcatcaaaa   9240

ctcacaactc tcttcagcac aggtcaagca gcaaggtctg gttctagttc ctctcccata   9300

agcctatcca ctgagaaaga aacaagcttc ctttccccca ctgcatccac ctccagaaag   9360

acttcactat ttcttgggcc ttccatggca aggcagccca acatattggt gcatcttcag   9420

acttcagctc tgacactttc tccaacatcc actctaaata tgtcccagga ggagcctcct   9480

gagttaacct caagccagac cattgcagaa gaagagggaa caacagctga aacacagacg   9540

ttaaccttca caccatctga gaccccaaca tccttgttac ctgtctcttc tcccacagaa   9600

cccacagcca gaagaaagag ttctccagaa acatgggcaa gctctatttc agttcctgcc   9660

aagacctcct tggttgaaac aactgatgga acgctagtga ccaccataaa gatgtcaagc   9720

caggcagcac aaggaaattc cacgtggcct gccccagcag aggagacggg gagcagtcca   9780

gcaggcacat ccccaggaag cccagaaatg tctaccactc tcaaaatcat gagctccaag   9840

gaacccagca tcagcccaga gatcaggtcc actgtgagaa attctccttg gaagactcca   9900

gaaacaactg ttcccatgga gaccacagtg gaaccagtca cccttcagtc cacagcccta   9960

ggaagtggca gcaccagcat ctctcacctg cccacaggaa ccacatcacc aaccaagtca  10020

ccaacagaaa atatgttggc tacagaaagg gtctccctct ccccatcccc acctgaggct  10080

tggaccaacc tttattctgg aactccagga gggaccaggc agtcactggc cacaatgtcc  10140

tctgtctccc tagagtcacc aactgctaga agcatcacag ggactggtca gcaaagcagt  10200

ccagaactgg tttcaaagac aactggaatg gaattctcta tgtggcatgg ctctactgga  10260

gggaccacag gggacacaca tgtctctctg agcacatctt ccaatatcct tgaagaccct  10320

gtaaccagcc caaactctgt gagctcattg acagataaat ccaaacataa aaccgagaca  10380

tgggtaagca ccacagccat tccctccact gtcctgaata ataagataat ggcagctgaa  10440

caacagacaa gtcgatctgt ggatgaggct tattcatcaa ctagttcttg gtcagatcag  10500

acatctggga gtgacatcac ccttggtgca tctcctgatg tcacaaacac attatacatc  10560

acctccacag cacaaaccac ctcactagtg tctctgccct ctggagacca aggcattaca  10620

agcctcacca atccctcagg aggaaaaaca agctctgcgt catctgtcac atctccttca  10680

atagggcttg agactctgag ggccaatgta agtgcagtga aaagtgacat tgcccctact  10740

gctgggcatc tatctcagac ttcatctcct gcggaagtga gcatcctgga cgtaaccaca  10800

gctcctactc caggtatctc caccaccatc accaccatgg gaaccaactc aatctcaact  10860

accacaccca acccagaagt gggtatgagt accatggaca gcaccccggc cacagagagg  10920

cgcacaactt ctacagaaca cccttccacc tggtcttcca cagctgcatc agattcctgg  10980

actgtcacag acatgacttc aaacttgaaa gttgcaagat ctcctggaac aatttccaca  11040

atgcatacaa cttcattctt agcctcaagc actgaattag actccatgtc tactccccat  11100

ggccgtataa ctgtcattgg aaccagcctg gtcactccat cctctgatgc ttcagctgta  11160

aagacagaga ccagtacaag tgaaagaaca ttgagtcctt cagacacaac tgcatctact  11220

cccatctcaa ctttttctcg tgtccagagg atgagcatct cagttcctga cattttaagt  11280

acaagttgga ctcccagtag tacagaagca gaagatgtgc ctgtttcaat ggtttctaca  11340

gatcatgcta gtacaaagac tgacccaaat acgcccctgt ccacttttct gtttgattct  11400

ctgtccactc ttgactggga cactgggaga tctctgtcat cagccacagc cactacctca  11460

gctcctcagg gggccacaac tccccaggaa ctcactttgg aaaccatgat cagcccagct  11520

acctcacagt tgcccttctc tatagggcac attacaagtg cagtcacacc agctgcaatg  11580

gcaaggagct ctggagttac tttttcaaga ccagatccca caagcaaaaa ggcagagcag  11640

acttccactc agcttcccac caccacttct gcacatccag ggcaggtgcc cagatcagca  11700

gcaacaactc tggatgtgat cccacacaca gcaaaaactc cagatgcaac ttttcagaga  11760

caagggcaga cagctcttac aacagaggca agagctacat ctgactcctg gaatgagaaa  11820

gaaaaatcaa ccccaagtgc accttggatc actgagatga tgaattctgt ctcagaagat  11880

accatcaagg aggttaccag ctcctccagt gtattaagga ccctgaatac gctggacata  11940

aacttggaat ctgggacgac ttcatcccca agttggaaaa gcagcccata tgagagaatt  12000

gccccttctg agtccaccac agacaaagag gcaattcacc cttctacaaa cacagtagag  12060

accacaggct gggtcacaag ttccgaacat gcttctcatt ccactatccc agcccactca  12120

gcgtcatcca aactcacatc tccagtggtt acaacctcca ccagggaaca agcaatagtt  12180

tctatgtcaa caaccacatg gccagagtct acaagggcta gaacagagcc taattccttc  12240

ttgactattg aactgaggga cgtcagccct tacatggaca ccagctcaac cacacaaaca  12300

agtattatct cttccccagg ttccactgcg atcaccaagg ggcctagaac agaaattacc  12360

tcctctaaga gaatatccag ctcattcctt gcccagtcta tgaggtcgtc agacagcccc  12420

tcagaagcca tcaccaggct gtctaacttt cctgccatga cagaatctgg aggaatgatc  12480

cttgctatgc aaacaagtcc acctggcgct acatcactaa gtgcacctac tttggataca  12540

tcagccacag cctcctggac agggactcca ctggctacga ctcagagatt tacatactca  12600

gagaagacca ctctctttag caaaggtcct gaggatacat cacagccaag ccctccctct  12660

gtggaagaaa ccagctcttc ctcttccctg gtacctatcc atgctacaac ctcgccttcc  12720

aatattttgt tgacatcaca agggcacagt ccctcctcta ctccacctgt gacctcagtt  12780

ttcttgtctg agacctctgg cctggggaag accacagaca tgtcgaggat aagcttggaa  12840

cctggcacaa gtttacctcc caatttgagc agtacagcag gtgaggcgtt atccacttat  12900

gaagcctcca gagatacaaa ggcaattcat cattctgcag acacagcagt gacgaatatg  12960

gaggcaacca gttctgaata ttctcctatc ccaggccata caaagccatc caaagccaca  13020

tctccattgg ttacctccca catcatgggg gacatcactt cttccacatc agtatttggc  13080

tcctccgaga ccacagagat tgagacagtg tcctctgtga accagggact tcaggagaga  13140

agcacatccc aggtggccag ctctgctaca gagacaagca ctgtcattac ccatgtgtct  13200

agtggtgatg ctactactca tgtcaccaag acacaagcca ctttctctag cggaacatcc  13260

atctcaagcc ctcatcagtt tataacttct accaacacat ttacagatgt gagcaccaac  13320

ccctccacct ctctgataat gacagaatct tcaggagtga ccatcaccac ccaaacaggt  13380

cctactggag ctgcaacaca gggtccatat ctcttggaca catcaaccat gccttacttg  13440

acagagactc cattagctgt gactccagat tttatgcaat cagagaagac cactctcata  13500

agcaaaggtc ccaaggatgt gtcctggaca agccctccct ctgtggcaga aaccagctat  13560

ccctcttccc tgacaccttt cttggtcaca accatacctc ctgccacttc cacgttacaa  13620

gggcaacata catcctctcc tgtttctgcg acttcagttc ttacctctgg actggtgaag  13680

accacagata tgttgaacac aagcatggaa cctgtgacca attcacctca aaatttgaac  13740

aatccatcaa atgagatact ggccactttg gcagccacca cagatataga gactattcat  13800

ccttccataa acaaagcagt gaccaatatg gggactgcca gttcagcaca tgtactgcat  13860

tccactctcc cagtcagctc agaaccatct acagccacat ctccaatggt tcctgcctcc  13920

agcatggggg acgctcttgc ttctatatca atacctggtt ctgagaccac agacattgag  13980

ggagagccaa catcctccct gactgctgga cgaaaagaga acagcaccct ccaggagatg  14040

aactcaacta cagagtcaaa catcatcctc tccaatgtgt ctgtgggggc tattactgaa  14100

gccacaaaaa tggaagtccc ctcttttgat gcaacattca taccaactcc tgctcagtca  14160

acaaagttcc cagatatttt ctcagtagcc agcagtagac tttcaaactc tcctcccatg  14220

acaatatcta cccacatgac caccacccag acagggtctt ctggagctac atcaaagatt  14280

ccacttgcct tagacacatc aaccttggaa acctcagcag ggactccatc agtggtgact  14340

gaggggtttg cccactcaaa aataaccact gcaatgaaca atgatgtcaa ggacgtgtca  14400

cagacaaacc ctccctttca ggatgaagcc agctctccct cttctcaagc acctgtcctt  14460

gtcacaacct taccttcttc tgttgctttc acaccgcaat ggcacagtac ctcctctcct  14520

gtttctatgt cctcagttct tacttcttca ctggtaaaga ccgcaggcaa ggtggataca  14580

agcttagaaa cagtgaccag ttcacctcaa agtatgagca acactttgga tgacatatcg  14640

gtcacttcag cagccaccac agatatagag acaacgcatc cttccataaa cacagtagtt  14700

accaatgtgg ggaccaccgg ttcagcattt gaatcacatt ctactgtctc agcttaccca  14760

gagccatcta aagtcacatc tccaaatgtt accacctcca ccatggaaga caccacaatt  14820

tccagatcaa tacctaaatc ctctaagact acaagaactg agactgagac aacttcctcc  14880

ctgactccta aactgaggga gaccagcatc tcccaggaga tcacctcgtc cacagagaca  14940

agcactgttc cttacaaaga gctcactggt gccactaccg aggtatccag gacagatgtc  15000

acttcctcta gcagtacatc cttccctggc cctgatcagt ccacagtgtc actagacatc  15060

tccacagaaa ccaacaccag gctgtctacc tccccaataa tgacagaatc tgcagaaata  15120

accatcacca cccaaacagg tcctcatggg gctacatcac aggatacttt taccatggac  15180

ccatcaaata caacccccca ggcagggatc cactcagcta tgactcatgg attttcacaa  15240

ttggatgtga ccactcttat gagcagaatt ccacaggatg tatcatggac aagtcctccc  15300

tctgtggata aaaccagctc cccctcttcc tttctgtcct cacctgcaat gaccacacct  15360

tccctgattt cttctacctt accagaggat aagctctcct ctcctatgac ttcacttctc  15420

acctctggcc tagtgaagat tacagacata ttacgtacac gcttggaacc tgtgaccagc  15480

tcacttccaa atttcagcag cacctcagat aagatactgg ccacttctaa agacagtaaa  15540

gacacaaagg aaatttttcc ttctataaac acagaagaga ccaatgtgaa agccaacaac  15600

tctggacatg aatcccattc ccctgcactg gctgactcag agacacccaa agccacaact  15660

caaatggtta tcaccaccac tgtgggagat ccagctcctt ccacatcaat gccagtgcat  15720

ggttcctctg agactacaaa cattaagaga gagccaacat atttcttgac tcctagactg  15780

agagagacca gtacctctca ggagtccagc tttcccacgg acacaagttt tctactttcc  15840

aaagtcccca ctggtactat tactgaggtc tccagtacag gggtcaactc ttctagcaaa  15900

atttccaccc cagaccatga taagtccaca gtgccacctg acaccttcac aggagagatc  15960

cccagggtct tcacctcctc tattaagaca aaatctgcag aaatgacgat caccacccaa  16020

gcaagtcctc ctgagtctgc atcgcacagt acccttccct tggacacatc aaccacactt  16080

tcccagggag ggactcattc aactgtgact cagggattcc catactcaga ggtgaccact  16140

ctcatgggca tgggtcctgg gaatgtgtca tggatgacaa ctccccctgt ggaagaaacc  16200

agctctgtgt cttccctgat gtcttcacct gccatgacat ccccttctcc tgtttcctcc  16260

acatcaccac agagcatccc ctcctctcct cttcctgtga ctgcacttcc tacttctgtt  16320

ctggtgacaa ccacagatgt gttgggcaca acaagcccag agtctgtaac cagttcacct  16380

ccaaatttga gcagcatcac tcatgagaga ccggccactt acaaagacac tgcacacaca  16440

gaagccgcca tgcatcattc cacaaacacc gcagtgacca atgtagggac ttccgggtct  16500

ggacataaat cacaatcctc tgtcctagct gactcagaga catcgaaagc cacacctctg  16560

atgagtacca cctccaccct gggggacaca agtgtttcca catcaactcc taatatctct  16620

cagactaacc aaattcaaac agagccaaca gcatccctga gccctagact gagggagagc  16680

agcacgtctg agaagaccag ctcaacaaca gagacaaata ctgccttttc ttatgtgccc  16740

acaggtgcta ttactcaggc ctccagaaca gaaatctcct ctagcagaac atccatctca  16800

gaccttgatc ggcccacaat agcacccgac atctccacag gaatgatcac caggctcttc  16860

acctccccca tcatgacaaa atctgcagaa atgaccgtca ccactcaaac aactactcct  16920

ggggctacat cacagggtat ccttccctgg gacacatcaa ccacactttt ccagggaggg  16980

actcattcaa ccgtgtctca gggattccca cactcagaga taaccactct tcggagcaga  17040

acccctggag atgtgtcatg gatgacaact ccccctgtgg aagaaaccag ctctgggttt  17100

tccctgatgt caccttccat gacatcccct tctcctgttt cctccacatc accagagagc  17160

atcccctcct ctcctctccc tgtgactgca cttcttactt ctgttctggt gacaaccaca  17220

aatgtattgg gcacaacaag cccagagccc gtaacgagtt cacctccaaa tttaagcagc  17280

cccacacagg agagactgac cacttacaaa gacactgcgc acacagaagc catgcatgct  17340

tccatgcata caaacactgc agtggccaac gtggggacct ccatttctgg acatgaatca  17400

caatcttctg tcccagctga ttcacacaca tccaaagcca catctccaat gggtatcacc  17460

ttcgccatgg gggatacaag tgtttctaca tcaactcctg ccttctttga gactagaatt  17520

cagactgaat caacatcctc tttgattcct ggattaaggg acaccaggac gtctgaggag  17580

atcaacactg tgacagagac cagcactgtc ctttcagaag tgcccactac tactactact  17640

gaggtctcca ggacagaagt tatcacttcc agcagaacaa ccatctcagg gcctgatcat  17700

tccaaaatgt caccctacat ctccacagaa accatcacca ggctctccac ttttcctttt  17760

gtaacaggat ccacagaaat ggccatcacc aaccaaacag gtcctatagg gactatctca  17820

caggctaccc ttaccctgga cacatcaagc acagcttcct gggaagggac tcactcacct  17880

gtgactcaga gatttccaca ctcagaggag accactacta tgagcagaag tactaagggc  17940

gtgtcatggc aaagccctcc ctctgtggaa gaaaccagtt ctccttcttc cccagtgcct  18000

ttacctgcaa taacctcaca ttcatctctt tattccgcag tatcaggaag tagccccact  18060

tctgctctcc ctgtgacttc ccttctcacc tctggcagga ggaagaccat agacatgttg  18120

gacacacact cagaacttgt gaccagctcc ttaccaagtg caagtagctt ctcaggtgag  18180

atactcactt ctgaagcctc cacaaataca gagacaattc acttttcaga gaacacagca  18240

gaaaccaata tggggaccac caattctatg cataaactac attcctctgt ctcaatccac  18300

tcccagccat ccggacacac acctccaaag gttactggat ctatgatgga ggacgctatt  18360

gtttccacat caacacctgg ttctcctgag actaaaaatg ttgacagaga ctcaacatcc  18420

cctctgactc ctgaactgaa agaggacagc accgccctgg tgatgaactc aactacagag  18480

tcaaacactg ttttctccag tgtgtccctg gatgctgcta ctgaggtctc cagggcagaa  18540

gtcacctact atgatcctac attcatgcca gcttctgctc agtcaacaaa gtccccagac  18600

atttcacctg aagccagcag cagtcattct aactctcctc ccttgacaat atctacacac  18660

aagaccatcg ccacacaaac aggtccttct ggggtgacat ctcttggcca actgaccctg  18720

gacacatcaa ccatagccac ctcagcagga actccatcag ccagaactca ggattttgta  18780

gattcagaaa caaccagtgt catgaacaat gatctcaatg atgtgttgaa gacaagccct  18840

ttctctgcag aagaagccaa ctctctctct tctcaggcac ctctccttgt gacaacctca  18900

ccttctcctg taacttccac attgcaagag cacagtacct cctctcttgt ttctgtgacc  18960

tcagtaccca cccctacact ggcgaagatc acagacatgg acacaaactt agaacctgtg  19020

actcgttcac ctcaaaattt aaggaacacc ttggccactt cagaagccac cacagataca  19080

cacacaatgc atccttctat aaacacagca gtggccaatg tggggaccac cagttcacca  19140

aatgaattct attttactgt ctcacctgac tcagacccat ataaagccac atccgcagta  19200

gttatcactt ccacctcggg ggactcaata gtttccacat caatgcctag atcctctgcg  19260

atgaaaaaga ttgagtctga gacaactttc tccctgatat ttagactgag ggagactagc  19320

acctcccaga aaattggctc atcctcagac acaagcacgg tctttgacaa agcattcact  19380

gctgctacta ctgaggtctc cagaacagaa ctcacctcct ctagcagaac atccatccaa  19440

ggcactgaaa agcccacaat gtcaccggac acctccacaa gatctgtcac catgctttct  19500

acttttgctg gcctgacaaa atccgaagaa aggaccattg ccacccaaac aggtcctcat  19560

agggcgacat cacagggtac ccttacctgg gacacatcaa tcacaacctc acaggcaggg  19620

acccactcag ctatgactca tggattttca caattagatt tgtccactct tacgagtaga  19680

gttcctgagt acatatcagg gacaagccca ccctctgtgg aaaaaaccag ctcttcctct  19740

tcccttctgt ctttaccagc aataacctca ccgtcccctg tacctactac attaccagaa  19800

agtaggccgt cttctcctgt tcatctgact tcactcccca cctctggcct agtgaagacc  19860

acagatatgc tggcatctgt ggccagttta cctccaaact tgggcagcac ctcacataag  19920

ataccgacta cttcagaaga cattaaagat acagagaaaa tgtatccttc cacaaacata  19980

gcagtaacca atgtggggac caccacttct gaaaaggaat cttattcgtc tgtcccagcc  20040

tactcagaac cacccaaagt cacctctcca atggttacct ctttcaacat aagggacacc  20100

attgtttcca catccatgcc tggctcctct gagattacaa ggattgagat ggagtcaaca  20160

ttctccctgg ctcatgggct gaagggaacc agcacctccc aggaccccat cgtatccaca  20220

gagaaaagtg ctgtccttca caagttgacc actggtgcta ctgagacctc taggacagaa  20280

gttgcctctt ctagaagaac atccattcca ggccctgatc attccacaga gtcaccagac  20340

atctccactg aagtgatccc cagcctgcct atctcccttg gcattacaga atcttcaaat  20400

atgaccatca tcactcgaac aggtcctcct cttggctcta catcacaggg cacatttacc  20460

ttggacacac caactacatc ctccagggca ggaacacact cgatggcgac tcaggaattt  20520

ccacactcag aaatgaccac tgtcatgaac aaggaccctg agattctatc atggacaatc  20580

cctccttcta tagagaaaac cagcttctcc tcttccctga tgccttcacc agccatgact  20640

tcacctcctg tttcctcaac attaccaaag accattcaca ccactccttc tcctatgacc  20700

tcactgctca cccctagcct agtgatgacc acagacacat tgggcacaag cccagaacct  20760

acaaccagtt cacctccaaa tttgagcagt acctcacatg agatactgac aacagatgaa  20820

gacaccacag ctatagaagc catgcatcct tccacaagca cagcagcgac taatgtggaa  20880

accaccagtt ctggacatgg gtcacaatcc tctgtcctag ctgactcaga aaaaaccaag  20940

gccacagctc caatggatac cacctccacc atggggcata caactgtttc cacatcaatg  21000

tctgtttcct ctgagactac aaaaattaag agagagtcaa catattcctt gactcctgga  21060

ctgagagaga ccagcatttc ccaaaatgcc agcttttcca ctgacacaag tattgttctt  21120

tcagaagtcc ccactggtac tactgctgag gtctccagga cagaagtcac ctcctctggt  21180

agaacatcca tccctggccc ttctcagtcc acagttttgc cagaaatatc cacaagaaca  21240

atgacaaggc tctttgcctc gcccaccatg acagaatcag cagaaatgac catccccact  21300

caaacaggtc cttctgggtc tacctcacag gataccctta ccttggacac atccaccaca  21360

aagtcccagg caaagactca ttcaactttg actcagagat ttccacactc agagatgacc  21420

actctcatga gcagaggtcc tggagatatg tcatggcaaa gctctccctc tctggaaaat  21480

cccagctctc tcccttccct gctgtcttta cctgccacaa cctcacctcc tcccatttcc  21540

tccacattac cagtgactat ctcctcctct cctcttcctg tgacttcact tctcacctct  21600

agcccggtaa cgaccacaga catgttacac acaagcccag aacttgtaac cagttcacct  21660

ccaaagctga gccacacttc agatgagaga ctgaccactg gcaaggacac cacaaataca  21720

gaagctgtgc atccttccac aaacacagca gcgtccaatg tggagattcc cagctctgga  21780

catgaatccc cttcctctgc cttagctgac tcagagacat ccaaagccac atcaccaatg  21840

tttattacct ccacccagga ggatacaact gttgccatat caacccctca cttcttggag  21900

actagcagaa ttcagaaaga gtcaatttcc tccctgagcc ctaaattgag ggagacaggc  21960

agttctgtgg agacaagctc agccatagag acaagtgctg tcctttctga agtgtccatt  22020

ggtgctacta ctgagatctc caggacagaa gtcacctcct ctagcagaac atccatctct  22080

ggttctgctg agtccacaat gttgccagaa atatccacca caagaaaaat cattaagttc  22140

cctacttccc ccatcctggc agaatcatca gaaatgacca tcaagaccca aacaagtcct  22200

cctgggtcta catcagagag tacctttaca ttagacacat caaccactcc ctccttggta  22260

ataacccatt cgactatgac tcagagattg ccacactcag agataaccac tcttgtgagt  22320

agaggtgctg gggatgtgcc acggcccagc tctctccctg tggaagaaac aagccctcca  22380

tcttcccagc tgtctttatc tgccatgatc tcaccttctc ctgtttcttc cacattacca  22440

gcaagtagcc actcctcttc tgcttctgtg acttcacttc tcacaccagg ccaagtgaag  22500

actactgagg tgttggacgc aagtgcagaa cctgaaacca gttcacctcc aagtttgagc  22560

agcacctcag ttgaaatact ggccacctct gaagtcacca cagatacgga gaaaattcat  22620

cctttctcaa acacggcagt aaccaaagtt ggaacttcca gttctggaca tgaatcccct  22680

tcctctgtcc tacctgactc agagacaacc aaagccacat cggcaatggg taccatctcc  22740

attatggggg atacaagtgt ttctacatta actcctgcct tatctaacac taggaaaatt  22800

cagtcagagc cagcttcctc actgaccacc agattgaggg agaccagcac ctctgaagag  22860

accagcttag ccacagaagc aaacactgtt ctttctaaag tgtccactgg tgctactact  22920

gaggtctcca ggacagaagc catctccttt agcagaacat ccatgtcagg ccctgagcag  22980

tccacaatgt cacaagacat ctccatagga accatcccca ggatttctgc ctcctctgtc  23040

ctgacagaat ctgcaaaaat gaccatcaca acccaaacag gtccttcgga gtctacacta  23100

gaaagtaccc ttaatttgaa cacagcaacc acaccctctt gggtggaaac ccactctata  23160

gtaattcagg gatttccaca cccagagatg accacttcca tgggcagagg tcctggaggt  23220

gtgtcatggc ctagccctcc ctttgtgaaa gaaaccagcc ctccatcctc cccgctgtct  23280

ttacctgccg tgacctcacc tcatcctgtt tccaccacat tcctagcaca tatccccccc  23340

tctccccttc ctgtgacttc acttctcacc tctggcccgg cgacaaccac agatatcttg  23400

ggtacaagca cagaacctgg aaccagttca tcttcaagtt tgagcaccac ctcccatgag  23460

agactgacca cttacaaaga cactgcacat acagaagccg tgcatccttc cacaaacaca  23520

ggagggacca atgtggcaac caccagctct ggatataaat cacagtcctc tgtcctagct  23580

gactcatctc caatgtgtac cacctccacc atgggggata caagtgttct cacatcaact  23640

cctgccttcc ttgagactag gaggattcag acagagctag cttcctccct gacccctgga  23700

ttgagggagt ccagcggctc tgaagggacc agctcaggca ccaagatgag cactgtcctc  23760

tctaaagtgc ccactggtgc tactactgag atctccaagg aagacgtcac ctccatccca  23820

ggtcccgctc aatccacaat atcaccagac atctccacaa gaaccgtcag ctggttctct  23880

acatcccctg tcatgacaga atcagcagaa ataaccatga acacccatac aagtccttta  23940

ggggccacaa cacaaggcac cagtactttg gacacgtcaa gcacaacctc tttgacaatg  24000

acacactcaa ctatatctca aggattttca cactcacaga tgagcactct tatgaggagg  24060

ggtcctgagg atgtatcatg gatgagccct ccccttctgg aaaaaactag accttccttt  24120

tctctgatgt cttcaccagc cacaacttca ccttctcctg tttcctccac attaccagag  24180

agcatctctt cctctcctct tcctgtgact tcactcctca cgtctggctt ggcaaaaact  24240

acagatatgt tgcacaaaag ctcagaacct gtaaccaact cacctgcaaa tttgagcagc  24300

acctcagttg aaatactggc cacctctgaa gtcaccacag atacagagaa aactcatcct  24360

tcttcaaaca gaacagtgac cgatgtgggg acctccagtt ctggacatga atccacttcc  24420

tttgtcctag ctgactcaca gacatccaaa gtcacatctc caatggttat tacctccacc  24480

atggaggata cgagtgtctc cacatcaact cctggctttt ttgagactag cagaattcag  24540

acagaaccaa catcctccct gacccttgga ctgagaaaga ccagcagctc tgaggggacc  24600

agcttagcca cagagatgag cactgtcctt tctggagtgc ccactggtgc cactgctgaa  24660

gtctccagga cagaagtcac ctcctctagc agaacatcca tctcaggctt tgctcagctc  24720

acagtgtcac cagagacttc cacagaaacc atcaccagac tccctacctc cagcataatg  24780

acagaatcag cagaaatgat gatcaagaca caaacagatc ctcctgggtc tacaccagag  24840

agtactcata ctgtggacat atcaacaaca cccaactggg tagaaaccca ctcgactgtg  24900

actcagagat tttcacactc agagatgacc actcttgtga gcagaagccc tggtgatatg  24960

ttatggccta gtcaatcctc tgtggaagaa accagctctg cctcttccct gctgtctctg  25020

cctgccacga cctcaccttc tcctgtttcc tctacattag tagaggattt cccttccgct  25080

tctcttcctg tgacttctct tctcaaccct ggcctggtga taaccacaga caggatgggc  25140

ataagcagag aacctggaac cagttccact tcaaatttga gcagcacctc ccatgagaga  25200

ctgaccactt tggaagacac tgtagataca gaagacatgc agccttccac acacacagca  25260

gtgaccaacg tgaggacctc catttctgga catgaatcac aatcttctgt cctatctgac  25320

tcagagacac ccaaagccac atctccaatg ggtaccacct acaccatggg ggaaacgagt  25380

gtttccatat ccacttctga cttctttgag accagcagaa ttcagataga accaacatcc  25440

tccctgactt ctggattgag ggagaccagc agctctgaga ggatcagctc agccacagag  25500

ggaagcactg tcctttctga agtgcccagt ggtgctacca ctgaggtctc caggacagaa  25560

gtgatatcct ctaggggaac atccatgtca gggcctgatc agttcaccat atcaccagac  25620

atctctactg aagcgatcac caggctttct acttccccca ttatgacaga atcagcagaa  25680

agtgccatca ctattgagac aggttctcct ggggctacat cagagggtac cctcaccttg  25740

gacacctcaa caacaacctt ttggtcaggg acccactcaa ctgcatctcc aggattttca  25800

cactcagaga tgaccactct tatgagtaga actcctggag atgtgccatg gccgagcctt  25860

ccctctgtgg aagaagccag ctctgtctct tcctcactgt cttcacctgc catgacctca  25920

acttcttttt tctccacatt accagagagc atctcctcct ctcctcatcc tgtgactgca  25980

cttctcaccc ttggcccagt gaagaccaca gacatgttgc gcacaagctc agaacctgaa  26040

accagttcac ctccaaattt gagcagcacc tcagctgaaa tattagccac gtctgaagtc  26100

accaaagata gagagaaaat tcatccctcc tcaaacacac ctgtagtcaa tgtagggact  26160

gtgatttata aacatctatc cccttcctct gttttggctg acttagtgac aacaaaaccc  26220

acatctccaa tggctaccac ctccactctg gggaatacaa gtgtttccac atcaactcct  26280

gccttcccag aaactatgat gacacagcca acttcctccc tgacttctgg attaagggag  26340

atcagtacct ctcaagagac cagctcagca acagagagaa gtgcttctct ttctggaatg  26400

cccactggtg ctactactaa ggtctccaga acagaagccc tctccttagg cagaacatcc  26460

accccaggtc ctgctcaatc cacaatatca ccagaaatct ccacggaaac catcactaga  26520

atttctactc ccctcaccac gacaggatca gcagaaatga ccatcacccc caaaacaggt  26580

cattctgggg catcctcaca aggtaccttt accttggaca catcaagcag agcctcctgg  26640

ccaggaactc actcagctgc aactcacaga tctccacact cagggatgac cactcctatg  26700

agcagaggtc ctgaggatgt gtcatggcca agccgcccat cagtggaaaa aactagccct  26760

ccatcttccc tggtgtcttt atctgcagta acctcacctt cgccacttta ttccacacca  26820

tctgagagta gccactcatc tcctctccgg gtgacttctc ttttcacccc tgtcatgatg  26880

aagaccacag acatgttgga cacaagcttg gaacctgtga ccacttcacc tcccagtatg  26940

aatatcacct cagatgagag tctggccact tctaaagcca ccatggagac agaggcaatt  27000

cagctttcag aaaacacagc tgtgactcag atgggcacca tcagcgctag acaagaattc  27060

tattcctctt atccaggcct cccagagcca tccaaagtga catctccagt ggtcacctct  27120

tccaccataa aagacattgt ttctacaacc atacctgctt cctctgagat aacaagaatt  27180

gagatggagt caacatccac cctgaccccc acaccaaggg agaccagcac ctcccaggag  27240

atccactcag ccacaaagcc aagcactgtt ccttacaagg cactcactag tgccacgatt  27300

gaggactcca tgacacaagt catgtcctct agcagaggac ctagccctga tcagtccaca  27360

atgtcacaag acatatccac tgaagtgatc accaggctct ctacctcccc catcaagaca  27420

gaatctacag aaatgaccat taccacccaa acaggttctc ctggggctac atcaaggggt  27480

acccttacct tggacacttc aacaactttt atgtcaggga cccactcaac tgcatctcaa  27540

ggattttcac actcacagat gaccgctctt atgagtagaa ctcctggaga tgtgccatgg  27600

ctaagccatc cctctgtgga agaagccagc tctgcctctt tctcactgtc ttcacctgtc  27660

atgacctcat cttctcccgt ttcttccaca ttaccagaca gcatccactc ttcttcgctt  27720

cctgtgacat cacttctcac ctcagggctg gtgaagacca cagagctgtt gggcacaagc  27780

tcagaacctg aaaccagttc acccccaaat ttgagcagca cctcagctga aatactggcc  27840

atcactgaag tcactacaga tacagagaaa ctggagatga ccaatgtggt aacctcaggt  27900

tatacacatg aatctccttc ctctgtccta gctgactcag tgacaacaaa ggccacatct  27960

tcaatgggta tcacctaccc cacaggagat acaaatgttc tcacatcaac ccctgccttc  28020

tctgacacca gtaggattca aacaaagtca aagctctcac tgactcctgg gttgatggag  28080

accagcatct ctgaagagac cagctctgcc acagaaaaaa gcactgtcct ttctagtgtg  28140

cccactggtg ctactactga ggtctccagg acagaagcca tctcttctag cagaacatcc  28200

atcccaggcc ctgctcaatc cacaatgtca tcagacacct ccatggaaac catcactaga  28260

atttctaccc ccctcacaag gaaagaatca acagacatgg ccatcacccc caaaacaggt  28320

ccttctgggg ctacctcgca gggtaccttt accttggact catcaagcac agcctcctgg  28380

ccaggaactc actcagctac aactcagaga tttccacagt cagtggtgac aactcctatg  28440

agcagaggtc ctgaggatgt gtcatggcca agcccgctgt ctgtggaaaa aaacagccct  28500

ccatcttccc tggtatcttc atcttcagta acctcacctt cgccacttta ttccacacca  28560

tctgggagta gccactcctc tcctgtccct gtcacttctc ttttcacctc tatcatgatg  28620

aaggccacag acatgttgga tgcaagtttg gaacctgaga ccacttcagc tcccaatatg  28680

aatatcacct cagatgagag tctggccgct tctaaagcca ccacggagac agaggcaatt  28740

cacgtttttg aaaatacagc agcgtcccat gtggaaacca ccagtgctac agaggaactc  28800

tattcctctt ccccaggctt ctcagagcca acaaaagtga tatctccagt ggtcacctct  28860

tcctctataa gagacaacat ggtttccaca acaatgcctg gctcctctgg cattacaagg  28920

attgagatag agtcaatgtc atctctgacc cctggactga gggagaccag aacctcccag  28980

gacatcacct catccacaga gacaagcact gtcctttaca agatgccctc tggtgccact  29040

cctgaggtct ccaggacaga agttatgccc tctagcagaa catccattcc tggccctgct  29100

cagtccacaa tgtcactaga catctccgat gaagttgtca ccaggctgtc tacctctccc  29160

atcatgacag aatctgcaga aataaccatc accacccaaa caggttattc tctggctaca  29220

tcccaggtta cccttccctt gggcacctca atgacctttt tgtcagggac ccactcaact  29280

atgtctcaag gactttcaca ctcagagatg accaatctta tgagcagggg tcctgaaagt  29340

ctgtcatgga cgagccctcg ctttgtggaa acaactagat cttcctcttc tctgacatca  29400

ttacctctca cgacctcact ttctcctgtg tcctccacat tactagacag tagcccctcc  29460

tctcctcttc ctgtgacttc acttatcctc ccaggcctgg tgaagactac agaagtgttg  29520

gatacaagct cagagcctaa aaccagttca tctccaaatt tgagcagcac ctcagttgaa  29580

ataccggcca cctctgaaat catgacagat acagagaaaa ttcatccttc ctcaaacaca  29640

gcggtggcca aagtgaggac ctccagttct gttcatgaat ctcattcctc tgtcctagct  29700

gactcagaaa caaccataac cataccttca atgggtatca cctccgctgt ggacgatacc  29760

actgttttca catcaaatcc tgccttctct gagactagga ggattccgac agagccaaca  29820

ttctcattga ctcctggatt cagggagact agcacctctg aagagaccac ctcaatcaca  29880

gaaacaagtg cagtccttta tggagtgccc actagtgcta ctactgaagt ctccatgaca  29940

gaaatcatgt cctctaatag aatacacatc cctgactctg atcagtccac gatgtctcca  30000

gacatcatca ctgaagtgat caccaggctc tcttcctcat ccatgatgtc agaatcaaca  30060

caaatgacca tcaccaccca aaaaagttct cctggggcta cagcacagag tactcttacc  30120

ttggccacaa caacagcccc cttggcaagg acccactcaa ctgttcctcc tagattttta  30180

cactcagaga tgacaactct tatgagtagg agtcctgaaa atccatcatg gaagagctct  30240

ctctttgtgg aaaaaactag ctcttcatct tctctgttgt ccttacctgt cacgacctca  30300

ccttctgttt cttccacatt accgcagagt atcccttcct cctctttttc tgtgacttca  30360

ctcctcaccc caggcatggt gaagactaca gacacaagca cagaacctgg aaccagttta  30420

tctccaaatc tgagtggcac ctcagttgaa atactggctg cctctgaagt caccacagat  30480

acagagaaaa ttcatccttc ttcaagcatg gcagtgacca atgtgggaac caccagttct  30540

ggacatgaac tatattcctc tgtttcaatc cactcggagc catccaaggc tacataccca  30600

gtgggtactc cctcttccat ggctgaaacc tctatttcca catcaatgcc tgctaatttt  30660

gagaccacag gatttgaggc tgagccattt tctcatttga cttctggatt taggaagaca  30720

aacatgtccc tggacaccag ctcagtcaca ccaacaaata caccttcttc tcctgggtcc  30780

actcaccttt tacagagttc caagactgat ttcacctctt ctgcaaaaac atcatcccca  30840

gactggcctc cagcctcaca gtatactgaa attccagtgg acataatcac cccctttaat  30900

gcttctccat ctattacgga gtccactggg ataacctcct tcccagaatc caggtttact  30960

atgtctgtaa cagaaagtac tcatcatctg agtacagatt tgctgccttc agctgagact  31020

atttccactg gcacagtgat gccttctcta tcagaggcca tgacttcatt tgccaccact  31080

ggagttccac gagccatctc aggttcaggt agtccattct ctaggacaga gtcaggccct  31140

ggggatgcta ctctgtccac cattgcagag agcctgcctt catccactcc tgtgccattc  31200

tcctcttcaa ccttcactac cactgattct tcaaccatcc cagccctcca tgagataact  31260

tcctcttcag ctaccccata tagagtggac accagtcttg ggacagagag cagcactact  31320

gaaggacgct tggttatggt cagtactttg gacacttcaa gccaaccagg caggacatct  31380

tcatcaccca ttttggatac cagaatgaca gagagcgttg agctgggaac agtgacaagt  31440

gcttatcaag ttccttcact ctcaacacgg ttgacaagaa ctgatggcat tatggaacac  31500

atcacaaaaa tacccaatga agcagcacac agaggtacca taagaccagt caaaggccct  31560

cagacatcca cttcgcctgc cagtcctaaa ggactacaca caggagggac aaaaagaatg  31620

gagaccacca ccacagctct gaagaccacc accacagctc tgaagaccac ttccagagcc  31680

accttgacca ccagtgtcta tactcccact ttgggaacac tgactcccct caatgcatca  31740

atgcaaatgg ccagcacaat ccccacagaa atgatgatca caaccccata tgttttccct  31800

gatgttccag aaacgacatc ctcattggct accagcctgg gagcagaaac cagcacagct  31860

cttcccagga caaccccatc tgttttcaat agagaatcag agaccacagc ctcactggtc  31920

tctcgttctg gggcagagag aagtccggtt attcaaactc tagatgtttc ttctagtgag  31980

ccagatacaa cagcttcatg ggttatccat cctgcagaga ccatcccaac tgtttccaag  32040

acaaccccca attttttcca cagtgaatta gacactgtat cttccacagc caccagtcat  32100

ggggcagacg tcagctcagc cattccaaca aatatctcac ctagtgaact agatgcactg  32160

accccactgg tcactatttc ggggacagat actagtacaa cattcccaac actgactaag  32220

tccccacatg aaacagagac aagaaccaca tggctcactc atcctgcaga gaccagctca  32280

actattccca gaacaatccc caatttttct catcatgaat cagatgccac accttcaata  32340

gccaccagtc ctggggcaga aaccagttca gctattccaa ttatgactgt ctcacctggt  32400

gcagaagatc tggtgacctc acaggtcact agttctggga cagacagaaa tatgactatt  32460

ccaactttga ctctttctcc tggtgaacca aagacgatag cctcattagt cacccatcct  32520

gaagcacaga caagttcggc cattccaact tcaactatct cgcctgctgt atcacggttg  32580

gtgacctcaa tggtcaccag tttggcggca aagacaagta caactaatcg agctctgaca  32640

aactcccctg gtgaaccagc tacaacagtt tcattggtca cgcatcctgc acagaccagc  32700

ccaacagttc cctggacaac ttccattttt ttccatagta aatcagacac cacaccttca  32760

atgaccacca gtcatggggc agaatccagt tcagctgttc caactccaac tgtttcaact  32820

gaggtaccag gagtagtgac ccctttggtc accagttcta gggcagtgat cagtacaact  32880

attccaattc tgactctttc tcctggtgaa ccagagacca caccttcaat ggccaccagt  32940

catggggaag aagccagttc tgctattcca actccaactg tttcacctgg ggtaccagga  33000

gtggtgacct ctctggtcac tagttctagg gcagtgacta gtacaactat tccaattctg  33060

actttttctc ttggtgaacc agagaccaca ccttcaatgg ccaccagtca tgggacagaa  33120

gctggctcag ctgttccaac tgttttacct gaggtaccag gaatggtgac ctctctggtt  33180

gctagttcta gggcagtaac cagtacaact cttccaactc tgactctttc tcctggtgaa  33240

ccagagacca caccttcaat ggccaccagt catggggcag aagccagctc aactgttcca  33300

actgtttcac ctgaggtacc aggagtggtg acctctctgg tcactagttc tagtggagta  33360

aacagtacaa gtattccaac tctgattctt tctcctggtg aactagaaac cacaccttca  33420

atggccacca gtcatggggc agaagccagc tcagctgttc caactccaac tgtttcacct  33480

ggggtatcag gagtggtgac ccctctggtc actagttcca gggcagtgac cagtacaact  33540

attccaattc taactctttc ttctagtgag ccagagacca caccttcaat ggccaccagt  33600

catggggtag aagccagctc agctgttcta actgtttcac ctgaggtacc aggaatggtg  33660

acctctctgg tcactagttc tagagcagta accagtacaa ctattccaac tctgactatt  33720

tcttctgatg aaccagagac cacaacttca ttggtcaccc attctgaggc aaagatgatt  33780

tcagccattc caactttagc tgtctcccct actgtacaag ggctggtgac ttcactggtc  33840

actagttctg ggtcagagac cagtgcgttt tcaaatctaa ctgttgcctc aagtcaacca  33900

gagaccatag actcatgggt cgctcatcct gggacagaag caagttctgt tgttccaact  33960

ttgactgtct ccactggtga gccgtttaca aatatctcat tggtcaccca tcctgcagag  34020

agtagctcaa ctcttcccag gacaacctca aggttttccc acagtgaatt agacactatg  34080

ccttctacag tcaccagtcc tgaggcagaa tccagctcag ccatttcaac aactatttca  34140

cctggtatac caggtgtgct gacatcactg gtcactagct ctgggagaga catcagtgca  34200

acttttccaa cagtgcctga gtccccacat gaatcagagg caacagcctc atgggttact  34260

catcctgcag tcaccagcac aacagttccc aggacaaccc ctaattattc tcatagtgaa  34320

ccagacacca caccatcaat agccaccagt cctggggcag aagccacttc agattttcca  34380

acaataactg tctcacctga tgtaccagat atggtaacct cacaggtcac tagttctggg  34440

acagacacca gtataactat tccaactctg actctttctt ctggtgagcc agagaccaca  34500

acctcattta tcacctattc tgagacacac acaagttcag ccattccaac tctccctgtc  34560

tcccctggtg catcaaagat gctgacctca ctggtcatca gttctgggac agacagcact  34620

acaactttcc caacactgac ggagacccca tatgaaccag agacaacagc catacagctc  34680

attcatcctg cagagaccaa cacaatggtt cccaggacaa ctcccaagtt ttcccatagt  34740

aagtcagaca ccacactccc agtagccatc accagtcctg ggccagaagc cagttcagct  34800

gtttcaacga caactatctc acctgatatg tcagatctgg tgacctcact ggtccctagt  34860

tctgggacag acaccagtac aaccttccca acattgagtg agaccccata tgaaccagag  34920

actacagcca cgtggctcac tcatcctgca gaaaccagca caacggtttc tgggacaatt  34980

cccaactttt cccatagggg atcagacact gcaccctcaa tggtcaccag tcctggagta  35040

gacacgaggt caggtgttcc aactacaacc atcccaccca gtataccagg ggtagtgacc  35100

tcacaggtca ctagttctgc aacagacact agtacagcta ttccaacttt gactccttct  35160

cctggtgaac cagagaccac agcctcatca gctacccatc ctgggacaca gactggcttc  35220

actgttccaa ttcggactgt tccctctagt gagccagata caatggcttc ctgggtcact  35280

catcctccac agaccagcac acctgtttcc agaacaacct ccagtttttc ccatagtagt  35340

ccagatgcca cacctgtaat ggccaccagt cctaggacag aagccagttc agctgtactg  35400

acaacaatct cacctggtgc accagagatg gtgacttcac agatcactag ttctggggca  35460

gcaaccagta caactgttcc aactttgact cattctcctg gtatgccaga gaccacagcc  35520

ttattgagca cccatcccag aacagagaca agtaaaacat ttcctgcttc aactgtgttt  35580

cctcaagtat cagagaccac agcctcactc accattagac ctggtgcaga gactagcaca  35640

gctctcccaa ctcagacaac atcctctctc ttcaccctac ttgtaactgg aaccagcaga  35700

gttgatctaa gtccaactgc ttcacctggt gtttctgcaa aaacagcccc actttccacc  35760

catccaggga cagaaaccag cacaatgatt ccaacttcaa ctctttccct tggtttacta  35820

gagactacag gcttactggc caccagctct tcagcagaga ccagcacgag tactctaact  35880

ctgactgttt cccctgctgt ctctgggctt tccagtgcct ctataacaac tgataagccc  35940

caaactgtga cctcctggaa cacagaaacc tcaccatctg taacttcagt tggaccccca  36000

gaattttcca ggactgtcac aggcaccact atgaccttga taccatcaga gatgccaaca  36060

ccacctaaaa ccagtcatgg agaaggagtg agtccaacca ctatcttgag aactacaatg  36120

gttgaagcca ctaatttagc taccacaggt tccagtccca ctgtggccaa gacaacaacc  36180

accttcaata cactggctgg aagcctcttt actcctctga ccacacctgg gatgtccacc  36240

ttggcctctg agagtgtgac ctcaagaaca agttataacc atcggtcctg gatctccacc  36300

accagcagtt ataaccgtcg gtactggacc cctgccacca gcactccagt gacttctaca  36360

ttctccccag ggatttccac atcctccatc cccagctcca cagcagccac agtcccattc  36420

atggtgccat tcaccctcaa cttcaccatc accaacctgc agtacgagga ggacatgcgg  36480

caccctggtt ccaggaagtt caacgccaca gagagagaac tgcagggtct gctcaaaccc  36540

ttgttcagga atagcagtct ggaatacctc tattcaggct gcagactagc ctcactcagg  36600

ccagagaagg atagctcagc cacggcagtg gatgccatct gcacacatcg ccctgaccct  36660

gaagacctcg gactggacag agagcgactg tactgggagc tgagcaatct gacaaatggc  36720

atccaggagc tgggccccta caccctggac cggaacagtc tctatgtcaa tggtttcacc  36780

catcgaagct ctatgcccac caccagcact cctgggacct ccacagtgga tgtgggaacc  36840

tcagggactc catcctccag ccccagcccc acgactgctg gccctctcct gatgccgttc  36900

accctcaact tcaccatcac caacctgcag tacgaggagg acatgcgtcg cactggctcc  36960

aggaagttca acaccatgga gagtgtcctg cagggtctgc tcaagccctt gttcaagaac  37020

accagtgttg gccctctgta ctctggctgc agattgacct tgctcaggcc cgagaaagat  37080

ggggcagcca ctggagtgga tgccatctgc acccaccgcc ttgaccccaa aagccctgga  37140

ctcaacaggg agcagctgta ctgggagcta agcaaactga ccaatgacat tgaagagctg  37200

ggcccctaca ccctggacag gaacagtctc tatgtcaatg gtttcaccca tcagagctct  37260

gtgtccacca ccagcactcc tgggacctcc acagtggatc tcagaacctc agggactcca  37320

tcctccctct ccagccccac aattatggct gctggccctc tcctggtacc attcaccctc  37380

aacttcacca tcaccaacct gcagtatggg gaggacatgg gtcaccctgg ctccaggaag  37440

ttcaacacca cagagagggt cctgcagggt ctgcttggtc ccatattcaa gaacaccagt  37500

gttggccctc tgtactctgg ctgcagactg acctctctca ggtctgagaa ggatggagca  37560

gccactggag tggatgccat ctgcatccat catcttgacc ccaaaagccc tggactcaac  37620

agagagcggc tgtactggga gctgagccaa ctgaccaatg gcatcaaaga gctgggcccc  37680

tacaccctgg acaggaacag tctctatgtc aatggtttca cccatcggac ctctgtgccc  37740

accagcagca ctcctgggac ctccacagtg gaccttggaa cctcagggac tccattctcc  37800

ctcccaagcc ccgcaactgc tggccctctc ctggtgctgt tcaccctcaa cttcaccatc  37860

accaacctga agtatgagga ggacatgcat cgccctggct ccaggaagtt caacaccact  37920

gagagggtcc tgcagactct gcttggtcct atgttcaaga acaccagtgt tggccttctg  37980

tactctggct gcagactgac cttgctcagg tccgagaagg atggagcagc cactggagtg  38040

gatgccatct gcacccaccg tcttgacccc aaaagccctg gagtggacag ggagcagcta  38100

tactgggagc tgagccagct gaccaatggc atcaaagagc tgggccccta caccctggac  38160

aggaacagtc tctatgtcaa tggtttcacc cattggatcc ctgtgcccac cagcagcact  38220

cctgggacct ccacagtgga ccttgggtca gggactccat cctccctccc cagccccaca  38280

actgctggcc ctctcctggt gccgttcacc ctcaacttca ccatcaccaa cctgaagtac  38340

gaggaggaca tgcattgccc tggctccagg aagttcaaca ccacagagag agtcctgcag  38400

agtctgcttg gtcccatgtt caagaacacc agtgttggcc ctctgtactc tggctgcaga  38460

ctgaccttgc tcaggtccga gaaggatgga gcagccactg gagtggatgc catctgcacc  38520

caccgtcttg accccaaaag ccctggagtg gacagggagc agctatactg ggagctgagc  38580

cagctgacca atggcatcaa agagctgggt ccctacaccc tggacagaaa cagtctctat  38640

gtcaatggtt tcacccatca gacctctgcg cccaacacca gcactcctgg gacctccaca  38700

gtggaccttg ggacctcagg gactccatcc tccctcccca gccctacatc tgctggccct  38760

ctcctggtgc cattcaccct caacttcacc atcaccaacc tgcagtacga ggaggacatg  38820

catcacccag gctccaggaa gttcaacacc acggagcggg tcctgcaggg tctgcttggt  38880

cccatgttca agaacaccag tgtcggcctt ctgtactctg gctgcagact gaccttgctc  38940

aggcctgaga agaatggggc agccactgga atggatgcca tctgcagcca ccgtcttgac  39000

cccaaaagcc ctggactcaa cagagagcag ctgtactggg agctgagcca gctgacccat  39060

ggcatcaaag agctgggccc ctacaccctg gacaggaaca gtctctatgt caatggtttc  39120

acccatcgga gctctgtggc ccccaccagc actcctggga cctccacagt ggaccttggg  39180

acctcaggga ctccatcctc cctccccagc cccacaacag ctgttcctct cctggtgccg  39240

ttcaccctca actttaccat caccaatctg cagtatgggg aggacatgcg tcaccctggc  39300

tccaggaagt tcaacaccac agagagggtc ctgcagggtc tgcttggtcc cttgttcaag  39360

aactccagtg tcggccctct gtactctggc tgcagactga tctctctcag gtctgagaag  39420

gatggggcag ccactggagt ggatgccatc tgcacccacc accttaaccc tcaaagccct  39480

ggactggaca gggagcagct gtactggcag ctgagccaga tgaccaatgg catcaaagag  39540

ctgggcccct acaccctgga ccggaacagt ctctacgtca atggtttcac ccatcggagc  39600

tctgggctca ccaccagcac tccttggact tccacagttg accttggaac ctcagggact  39660

ccatcccccg tccccagccc cacaaccacc ggccctctcc tggtgccatt cacactcaac  39720

ttcaccatca ctaacctaca gtatgaggag aacatgggtc accctggctc caggaagttc  39780

aacatcacgg agagtgttct gcagggtctg ctcaagccct tgttcaagag caccagtgtt  39840

ggccctctgt attctggctg cagactgacc ttgctcaggc ctgagaagga tggagtagcc  39900

accagagtgg acgccatctg cacccaccgc cctgacccca aaatccctgg gctagacaga  39960

cagcagctat actgggagct gagccagctg acccacagca tcactgagct gggaccctac  40020

accctggata gggacagtct ctatgtcaat ggtttcaccc agcggagctc tgtgcccacc  40080

accagcactc ctgggacttt cacagtacag ccggaaacct ctgagactcc atcatccctc  40140

cctggcccca cagccactgg ccctgtcctg ctgccattca ccctcaattt taccatcact  40200

aacctgcagt atgaggagga catgcgtcgc cctggctcca ggaagttcaa caccacggag  40260

agggtccttc agggtctgct tatgcccttg ttcaagaaca ccagtgtcag ctctctgtac  40320

tctggttgca gactgacctt gctcaggcct gagaaggatg gggcagccac cagagtggat  40380

gctgtctgca cccatcgtcc tgaccccaaa agccctggac tggacagaga gcggctgtac  40440

tggaagctga gccagctgac ccacggcatc actgagctgg gcccctacac cctggacagg  40500

cacagtctct atgtcaatgg tttcacccat cagagctcta tgacgaccac cagaactcct  40560

gatacctcca caatgcacct ggcaacctcg agaactccag cctccctgtc tggacccatg  40620

accgccagcc ctctcctggt gctattcaca attaacttca ccatcactaa cctgcggtat  40680

gaggagaaca tgcatcaccc tggctctaga aagtttaaca ccacggagag agtccttcag  40740

ggtctgctca ggcctgtgtt caagaacacc agtgttggcc ctctgtactc tggctgcaga  40800

ctgaccttgc tcaggcccaa gaaggatggg gcagccacca aagtggatgc catctgcacc  40860

taccgccctg atcccaaaag ccctggactg gacagagagc agctatactg ggagctgagc  40920

cagctgaccc acagcatcac tgagctgggc ccctacaccc tggacaggga cagtctctat  40980

gtcaatggtt tcacacagcg gagctctgtg cccaccacta gcattcctgg gacccccaca  41040

gtggacctgg gaacatctgg gactccagtt tctaaacctg gtccctcggc tgccagccct  41100

ctcctggtgc tattcactct caacttcacc atcaccaacc tgcggtatga ggagaacatg  41160

cagcaccctg gctccaggaa gttcaacacc acggagaggg tccttcaggg cctgctcagg  41220

tccctgttca agagcaccag tgttggccct ctgtactctg gctgcagact gactttgctc  41280

aggcctgaaa aggatgggac agccactgga gtggatgcca tctgcaccca ccaccctgac  41340

cccaaaagcc ctaggctgga cagagagcag ctgtattggg agctgagcca gctgacccac  41400

aatatcactg agctgggccc ctatgccctg gacaacgaca gcctctttgt caatggtttc  41460

actcatcgga gctctgtgtc caccaccagc actcctggga cccccacagt gtatctggga  41520

gcatctaaga ctccagcctc gatatttggc ccttcagctg ccagccatct cctgatacta  41580

ttcaccctca acttcaccat cactaacctg cggtatgagg agaacatgtg gcctggctcc  41640

aggaagttca acactacaga gagggtcctt cagggcctgc taaggccctt gttcaagaac  41700

accagtgttg gccctctgta ctctggctgc aggctgacct tgctcaggcc agagaaagat  41760

ggggaagcca ccggagtgga tgccatctgc acccaccgcc ctgaccccac aggccctggg  41820

ctggacagag agcagctgta tttggagctg agccagctga cccacagcat cactgagctg  41880

ggcccctaca cactggacag ggacagtctc tatgtcaatg gtttcaccca tcggagctct  41940

gtacccacca ccagcaccgg ggtggtcagc gaggagccat tcacactgaa cttcaccatc  42000

aacaacctgc gctacatggc ggacatgggc caacccggct ccctcaagtt caacatcaca  42060

gacaacgtca tgcagcacct gctcagtcct ttgttccaga ggagcagcct gggtgcacgg  42120

tacacaggct gcagggtcat cgcactaagg tctgtgaaga acggtgctga gacacgggtg  42180

gacctcctct gcacctacct gcagcccctc agcggcccag gtctgcctat caagcaggtg  42240

ttccatgagc tgagccagca gacccatggc atcacccggc tgggccccta ctctctggac  42300

aaagacagcc tctaccttaa cggttacaat gaacctggtc cagatgagcc tcctacaact  42360

cccaagccag ccaccacatt cctgcctcct ctgtcagaag ccacaacagc catggggtac  42420

cacctgaaga ccctcacact caacttcacc atctccaatc tccagtattc accagatatg  42480

ggcaagggct cagctacatt caactccacc gagggggtcc ttcagcacct gctcagaccc  42540

ttgttccaga agagcagcat gggccccttc tacttgggtt gccaactgat ctccctcagg  42600

cctgagaagg atggggcagc cactggtgtg gacaccacct gcacctacca ccctgaccct  42660

gtgggccccg ggctggacat acagcagctt tactgggagc tgagtcagct gacccatggt  42720

gtcacccaac tgggcttcta tgtcctggac agggatagcc tcttcatcaa tggctatgca  42780

ccccagaatt tatcaatccg gggcgagtac cagataaatt tccacattgt caactggaac  42840

ctcagtaatc cagaccccac atcctcagag tacatcaccc tgctgaggga catccaggac  42900

aaggtcacca cactctacaa aggcagtcaa ctacatgaca cattccgctt ctgcctggtc  42960

accaacttga cgatggactc cgtgttggtc actgtcaagg cattgttctc ctccaatttg  43020

gaccccagcc tggtggagca agtctttcta gataagaccc tgaatgcctc attccattgg  43080

ctgggctcca cctaccagtt ggtggacatc catgtgacag aaatggagtc atcagtttat  43140

caaccaacaa gcagctccag cacccagcac ttctacctga atttcaccat caccaaccta  43200

ccatattccc aggacaaagc ccagccaggc accaccaatt accagaggaa caaaaggaat  43260

attgaggatg cgctcaacca actcttccga aacagcagca tcaagagtta tttttctgac  43320

tgtcaagttt caacattcag gtctgtcccc aacaggcacc acaccggggt ggactccctg  43380

tgtaacttct cgccactggc tcggagagta gacagagttg ccatctatga ggaatttctg  43440

cggatgaccc ggaatggtac ccagctgcag aacttcaccc tggacaggag cagtgtcctt  43500

gtggatgggt attctcccaa cagaaatgag cccttaactg ggaattctga ccttcccttc  43560

tgggctgtca tcctcatcgg cttggcagga ctcctgggag tcatcacatg cctgatctgc  43620

ggtgtcctgg tgaccacccg ccggcggaag aaggaaggag aatacaacgt ccagcaacag  43680

tgcccaggct actaccagtc acacctagac ctggaggatc tgcaatgact ggaacttgcc  43740

ggtgcctggg gtgcctttcc cccagccagg gtccaaagaa gcttggctgg ggcagaaata  43800

aaccatattg gtcgga                                                  43816


<210>  1150
<211>  14507
<212>  PRT
<213>  Homo sapiens

<400>  1150

Met Leu Lys Pro Ser Gly Leu Pro Gly Ser Ser Ser Pro Thr Arg Ser 
1               5                   10                  15      


Leu Met Thr Gly Ser Arg Ser Thr Lys Ala Thr Pro Glu Met Asp Ser 
            20                  25                  30          


Gly Leu Thr Gly Ala Thr Leu Ser Pro Lys Thr Ser Thr Gly Ala Ile 
        35                  40                  45              


Val Val Thr Glu His Thr Leu Pro Phe Thr Ser Pro Asp Lys Thr Leu 
    50                  55                  60                  


Ala Ser Pro Thr Ser Ser Val Val Gly Arg Thr Thr Gln Ser Leu Gly 
65                  70                  75                  80  


Val Met Ser Ser Ala Leu Pro Glu Ser Thr Ser Arg Gly Met Thr His 
                85                  90                  95      


Ser Glu Gln Arg Thr Ser Pro Ser Leu Ser Pro Gln Val Asn Gly Thr 
            100                 105                 110         


Pro Ser Arg Asn Tyr Pro Ala Thr Ser Met Val Ser Gly Leu Ser Ser 
        115                 120                 125             


Pro Arg Thr Arg Thr Ser Ser Thr Glu Gly Asn Phe Thr Lys Glu Ala 
    130                 135                 140                 


Ser Thr Tyr Thr Leu Thr Val Glu Thr Thr Ser Gly Pro Val Thr Glu 
145                 150                 155                 160 


Lys Tyr Thr Val Pro Thr Glu Thr Ser Thr Thr Glu Gly Asp Ser Thr 
                165                 170                 175     


Glu Thr Pro Trp Asp Thr Arg Tyr Ile Pro Val Lys Ile Thr Ser Pro 
            180                 185                 190         


Met Lys Thr Phe Ala Asp Ser Thr Ala Ser Lys Glu Asn Ala Pro Val 
        195                 200                 205             


Ser Met Thr Pro Ala Glu Thr Thr Val Thr Asp Ser His Thr Pro Gly 
    210                 215                 220                 


Arg Thr Asn Pro Ser Phe Gly Thr Leu Tyr Ser Ser Phe Leu Asp Leu 
225                 230                 235                 240 


Ser Pro Lys Gly Thr Pro Asn Ser Arg Gly Glu Thr Ser Leu Glu Leu 
                245                 250                 255     


Ile Leu Ser Thr Thr Gly Tyr Pro Phe Ser Ser Pro Glu Pro Gly Ser 
            260                 265                 270         


Ala Gly His Ser Arg Ile Ser Thr Ser Ala Pro Leu Ser Ser Ser Ala 
        275                 280                 285             


Ser Val Leu Asp Asn Lys Ile Ser Glu Thr Ser Ile Phe Ser Gly Gln 
    290                 295                 300                 


Ser Leu Thr Ser Pro Leu Ser Pro Gly Val Pro Glu Ala Arg Ala Ser 
305                 310                 315                 320 


Thr Met Pro Asn Ser Ala Ile Pro Phe Ser Met Thr Leu Ser Asn Ala 
                325                 330                 335     


Glu Thr Ser Ala Glu Arg Val Arg Ser Thr Ile Ser Ser Leu Gly Thr 
            340                 345                 350         


Pro Ser Ile Ser Thr Lys Gln Thr Ala Glu Thr Ile Leu Thr Phe His 
        355                 360                 365             


Ala Phe Ala Glu Thr Met Asp Ile Pro Ser Thr His Ile Ala Lys Thr 
    370                 375                 380                 


Leu Ala Ser Glu Trp Leu Gly Ser Pro Gly Thr Leu Gly Gly Thr Ser 
385                 390                 395                 400 


Thr Ser Ala Leu Thr Thr Thr Ser Pro Ser Thr Thr Leu Val Ser Glu 
                405                 410                 415     


Glu Thr Asn Thr His His Ser Thr Ser Gly Lys Glu Thr Glu Gly Thr 
            420                 425                 430         


Leu Asn Thr Ser Met Thr Pro Leu Glu Thr Ser Ala Pro Gly Glu Glu 
        435                 440                 445             


Ser Glu Met Thr Ala Thr Leu Val Pro Thr Leu Gly Phe Thr Thr Leu 
    450                 455                 460                 


Asp Ser Lys Ile Arg Ser Pro Ser Gln Val Ser Ser Ser His Pro Thr 
465                 470                 475                 480 


Arg Glu Leu Arg Thr Thr Gly Ser Thr Ser Gly Arg Gln Ser Ser Ser 
                485                 490                 495     


Thr Ala Ala His Gly Ser Ser Asp Ile Leu Arg Ala Thr Thr Ser Ser 
            500                 505                 510         


Thr Ser Lys Ala Ser Ser Trp Thr Ser Glu Ser Thr Ala Gln Gln Phe 
        515                 520                 525             


Ser Glu Pro Gln His Thr Gln Trp Val Glu Thr Ser Pro Ser Met Lys 
    530                 535                 540                 


Thr Glu Arg Pro Pro Ala Ser Thr Ser Val Ala Ala Pro Ile Thr Thr 
545                 550                 555                 560 


Ser Val Pro Ser Val Val Ser Gly Phe Thr Thr Leu Lys Thr Ser Ser 
                565                 570                 575     


Thr Lys Gly Ile Trp Leu Glu Glu Thr Ser Ala Asp Thr Leu Ile Gly 
            580                 585                 590         


Glu Ser Thr Ala Gly Pro Thr Thr His Gln Phe Ala Val Pro Thr Gly 
        595                 600                 605             


Ile Ser Met Thr Gly Gly Ser Ser Thr Arg Gly Ser Gln Gly Thr Thr 
    610                 615                 620                 


His Leu Leu Thr Arg Ala Thr Ala Ser Ser Glu Thr Ser Ala Asp Leu 
625                 630                 635                 640 


Thr Leu Ala Thr Asn Gly Val Pro Val Ser Val Ser Pro Ala Val Ser 
                645                 650                 655     


Lys Thr Ala Ala Gly Ser Ser Pro Pro Gly Gly Thr Lys Pro Ser Tyr 
            660                 665                 670         


Thr Met Val Ser Ser Val Ile Pro Glu Thr Ser Ser Leu Gln Ser Ser 
        675                 680                 685             


Ala Phe Arg Glu Gly Thr Ser Leu Gly Leu Thr Pro Leu Asn Thr Arg 
    690                 695                 700                 


His Pro Phe Ser Ser Pro Glu Pro Asp Ser Ala Gly His Thr Lys Ile 
705                 710                 715                 720 


Ser Thr Ser Ile Pro Leu Leu Ser Ser Ala Ser Val Leu Glu Asp Lys 
                725                 730                 735     


Val Ser Ala Thr Ser Thr Phe Ser His His Lys Ala Thr Ser Ser Ile 
            740                 745                 750         


Thr Thr Gly Thr Pro Glu Ile Ser Thr Lys Thr Lys Pro Ser Ser Ala 
        755                 760                 765             


Val Leu Ser Ser Met Thr Leu Ser Asn Ala Ala Thr Ser Pro Glu Arg 
    770                 775                 780                 


Val Arg Asn Ala Thr Ser Pro Leu Thr His Pro Ser Pro Ser Gly Glu 
785                 790                 795                 800 


Glu Thr Ala Gly Ser Val Leu Thr Leu Ser Thr Ser Ala Glu Thr Thr 
                805                 810                 815     


Asp Ser Pro Asn Ile His Pro Thr Gly Thr Leu Thr Ser Glu Ser Ser 
            820                 825                 830         


Glu Ser Pro Ser Thr Leu Ser Leu Pro Ser Val Ser Gly Val Lys Thr 
        835                 840                 845             


Thr Phe Ser Ser Ser Thr Pro Ser Thr His Leu Phe Thr Ser Gly Glu 
    850                 855                 860                 


Glu Thr Glu Glu Thr Ser Asn Pro Ser Val Ser Gln Pro Glu Thr Ser 
865                 870                 875                 880 


Val Ser Arg Val Arg Thr Thr Leu Ala Ser Thr Ser Val Pro Thr Pro 
                885                 890                 895     


Val Phe Pro Thr Met Asp Thr Trp Pro Thr Arg Ser Ala Gln Phe Ser 
            900                 905                 910         


Ser Ser His Leu Val Ser Glu Leu Arg Ala Thr Ser Ser Thr Ser Val 
        915                 920                 925             


Thr Asn Ser Thr Gly Ser Ala Leu Pro Lys Ile Ser His Leu Thr Gly 
    930                 935                 940                 


Thr Ala Thr Met Ser Gln Thr Asn Arg Asp Thr Phe Asn Asp Ser Ala 
945                 950                 955                 960 


Ala Pro Gln Ser Thr Thr Trp Pro Glu Thr Ser Pro Arg Phe Lys Thr 
                965                 970                 975     


Gly Leu Pro Ser Ala Thr Thr Thr Val Ser Thr Ser Ala Thr Ser Leu 
            980                 985                 990         


Ser Ala Thr Val Met Val Ser Lys  Phe Thr Ser Pro Ala  Thr Ser Ser 
        995                 1000                 1005             


Met Glu  Ala Thr Ser Ile Arg  Glu Pro Ser Thr Thr  Ile Leu Thr 
    1010                 1015                 1020             


Thr Glu  Thr Thr Asn Gly Pro  Gly Ser Met Ala Val  Ala Ser Thr 
    1025                 1030                 1035             


Asn Ile  Pro Ile Gly Lys Gly  Tyr Ile Thr Glu Gly  Arg Leu Asp 
    1040                 1045                 1050             


Thr Ser  His Leu Pro Ile Gly  Thr Thr Ala Ser Ser  Glu Thr Ser 
    1055                 1060                 1065             


Met Asp  Phe Thr Met Ala Lys  Glu Ser Val Ser Met  Ser Val Ser 
    1070                 1075                 1080             


Pro Ser  Gln Ser Met Asp Ala  Ala Gly Ser Ser Thr  Pro Gly Arg 
    1085                 1090                 1095             


Thr Ser  Gln Phe Val Asp Thr  Phe Ser Asp Asp Val  Tyr His Leu 
    1100                 1105                 1110             


Thr Ser  Arg Glu Ile Thr Ile  Pro Arg Asp Gly Thr  Ser Ser Ala 
    1115                 1120                 1125             


Leu Thr  Pro Gln Met Thr Ala  Thr His Pro Pro Ser  Pro Asp Pro 
    1130                 1135                 1140             


Gly Ser  Ala Arg Ser Thr Trp  Leu Gly Ile Leu Ser  Ser Ser Pro 
    1145                 1150                 1155             


Ser Ser  Pro Thr Pro Lys Val  Thr Met Ser Ser Thr  Phe Ser Thr 
    1160                 1165                 1170             


Gln Arg  Val Thr Thr Ser Met  Ile Met Asp Thr Val  Glu Thr Ser 
    1175                 1180                 1185             


Arg Trp  Asn Met Pro Asn Leu  Pro Ser Thr Thr Ser  Leu Thr Pro 
    1190                 1195                 1200             


Ser Asn  Ile Pro Thr Ser Gly  Ala Ile Gly Lys Ser  Thr Leu Val 
    1205                 1210                 1215             


Pro Leu  Asp Thr Pro Ser Pro  Ala Thr Ser Leu Glu  Ala Ser Glu 
    1220                 1225                 1230             


Gly Gly  Leu Pro Thr Leu Ser  Thr Tyr Pro Glu Ser  Thr Asn Thr 
    1235                 1240                 1245             


Pro Ser  Ile His Leu Gly Ala  His Ala Ser Ser Glu  Ser Pro Ser 
    1250                 1255                 1260             


Thr Ile  Lys Leu Thr Met Ala  Ser Val Val Lys Pro  Gly Ser Tyr 
    1265                 1270                 1275             


Thr Pro  Leu Thr Phe Pro Ser  Ile Glu Thr His Ile  His Val Ser 
    1280                 1285                 1290             


Thr Ala  Arg Met Ala Tyr Ser  Ser Gly Ser Ser Pro  Glu Met Thr 
    1295                 1300                 1305             


Ala Pro  Gly Glu Thr Asn Thr  Gly Ser Thr Trp Asp  Pro Thr Thr 
    1310                 1315                 1320             


Tyr Ile  Thr Thr Thr Asp Pro  Lys Asp Thr Ser Ser  Ala Gln Val 
    1325                 1330                 1335             


Ser Thr  Pro His Ser Val Arg  Thr Leu Arg Thr Thr  Glu Asn His 
    1340                 1345                 1350             


Pro Lys  Thr Glu Ser Ala Thr  Pro Ala Ala Tyr Ser  Gly Ser Pro 
    1355                 1360                 1365             


Lys Ile  Ser Ser Ser Pro Asn  Leu Thr Ser Pro Ala  Thr Lys Ala 
    1370                 1375                 1380             


Trp Thr  Ile Thr Asp Thr Thr  Glu His Ser Thr Gln  Leu His Tyr 
    1385                 1390                 1395             


Thr Lys  Leu Ala Glu Lys Ser  Ser Gly Phe Glu Thr  Gln Ser Ala 
    1400                 1405                 1410             


Pro Gly  Pro Val Ser Val Val  Ile Pro Thr Ser Pro  Thr Ile Gly 
    1415                 1420                 1425             


Ser Ser  Thr Leu Glu Leu Thr  Ser Asp Val Pro Gly  Glu Pro Leu 
    1430                 1435                 1440             


Val Leu  Ala Pro Ser Glu Gln  Thr Thr Ile Thr Leu  Pro Met Ala 
    1445                 1450                 1455             


Thr Trp  Leu Ser Thr Ser Leu  Thr Glu Glu Met Ala  Ser Thr Asp 
    1460                 1465                 1470             


Leu Asp  Ile Ser Ser Pro Ser  Ser Pro Met Ser Thr  Phe Ala Ile 
    1475                 1480                 1485             


Phe Pro  Pro Met Ser Thr Pro  Ser His Glu Leu Ser  Lys Ser Glu 
    1490                 1495                 1500             


Ala Asp  Thr Ser Ala Ile Arg  Asn Thr Asp Ser Thr  Thr Leu Asp 
    1505                 1510                 1515             


Gln His  Leu Gly Ile Arg Ser  Leu Gly Arg Thr Gly  Asp Leu Thr 
    1520                 1525                 1530             


Thr Val  Pro Ile Thr Pro Leu  Thr Thr Thr Trp Thr  Ser Val Ile 
    1535                 1540                 1545             


Glu His  Ser Thr Gln Ala Gln  Asp Thr Leu Ser Ala  Thr Met Ser 
    1550                 1555                 1560             


Pro Thr  His Val Thr Gln Ser  Leu Lys Asp Gln Thr  Ser Ile Pro 
    1565                 1570                 1575             


Ala Ser  Ala Ser Pro Ser His  Leu Thr Glu Val Tyr  Pro Glu Leu 
    1580                 1585                 1590             


Gly Thr  Gln Gly Arg Ser Ser  Ser Glu Ala Thr Thr  Phe Trp Lys 
    1595                 1600                 1605             


Pro Ser  Thr Asp Thr Leu Ser  Arg Glu Ile Glu Thr  Gly Pro Thr 
    1610                 1615                 1620             


Asn Ile  Gln Ser Thr Pro Pro  Met Asp Asn Thr Thr  Thr Gly Ser 
    1625                 1630                 1635             


Ser Ser  Ser Gly Val Thr Leu  Gly Ile Ala His Leu  Pro Ile Gly 
    1640                 1645                 1650             


Thr Ser  Ser Pro Ala Glu Thr  Ser Thr Asn Met Ala  Leu Glu Arg 
    1655                 1660                 1665             


Arg Ser  Ser Thr Ala Thr Val  Ser Met Ala Gly Thr  Met Gly Leu 
    1670                 1675                 1680             


Leu Val  Thr Ser Ala Pro Gly  Arg Ser Ile Ser Gln  Ser Leu Gly 
    1685                 1690                 1695             


Arg Val  Ser Ser Val Leu Ser  Glu Ser Thr Thr Glu  Gly Val Thr 
    1700                 1705                 1710             


Asp Ser  Ser Lys Gly Ser Ser  Pro Arg Leu Asn Thr  Gln Gly Asn 
    1715                 1720                 1725             


Thr Ala  Leu Ser Ser Ser Leu  Glu Pro Ser Tyr Ala  Glu Gly Ser 
    1730                 1735                 1740             


Gln Met  Ser Thr Ser Ile Pro  Leu Thr Ser Ser Pro  Thr Thr Pro 
    1745                 1750                 1755             


Asp Val  Glu Phe Ile Gly Gly  Ser Thr Phe Trp Thr  Lys Glu Val 
    1760                 1765                 1770             


Thr Thr  Val Met Thr Ser Asp  Ile Ser Lys Ser Ser  Ala Arg Thr 
    1775                 1780                 1785             


Glu Ser  Ser Ser Ala Thr Leu  Met Ser Thr Ala Leu  Gly Ser Thr 
    1790                 1795                 1800             


Glu Asn  Thr Gly Lys Glu Lys  Leu Arg Thr Ala Ser  Met Asp Leu 
    1805                 1810                 1815             


Pro Ser  Pro Thr Pro Ser Met  Glu Val Thr Pro Trp  Ile Ser Leu 
    1820                 1825                 1830             


Thr Leu  Ser Asn Ala Pro Asn  Thr Thr Asp Ser Leu  Asp Leu Ser 
    1835                 1840                 1845             


His Gly  Val His Thr Ser Ser  Ala Gly Thr Leu Ala  Thr Asp Arg 
    1850                 1855                 1860             


Ser Leu  Asn Thr Gly Val Thr  Arg Ala Ser Arg Leu  Glu Asn Gly 
    1865                 1870                 1875             


Ser Asp  Thr Ser Ser Lys Ser  Leu Ser Met Gly Asn  Ser Thr His 
    1880                 1885                 1890             


Thr Ser  Met Thr Tyr Thr Glu  Lys Ser Glu Val Ser  Ser Ser Ile 
    1895                 1900                 1905             


His Pro  Arg Pro Glu Thr Ser  Ala Pro Gly Ala Glu  Thr Thr Leu 
    1910                 1915                 1920             


Thr Ser  Thr Pro Gly Asn Arg  Ala Ile Ser Leu Thr  Leu Pro Phe 
    1925                 1930                 1935             


Ser Ser  Ile Pro Val Glu Glu  Val Ile Ser Thr Gly  Ile Thr Ser 
    1940                 1945                 1950             


Gly Pro  Asp Ile Asn Ser Ala  Pro Met Thr His Ser  Pro Ile Thr 
    1955                 1960                 1965             


Pro Pro  Thr Ile Val Trp Thr  Ser Thr Gly Thr Ile  Glu Gln Ser 
    1970                 1975                 1980             


Thr Gln  Pro Leu His Ala Val  Ser Ser Glu Lys Val  Ser Val Gln 
    1985                 1990                 1995             


Thr Gln  Ser Thr Pro Tyr Val  Asn Ser Val Ala Val  Ser Ala Ser 
    2000                 2005                 2010             


Pro Thr  His Glu Asn Ser Val  Ser Ser Gly Ser Ser  Thr Ser Ser 
    2015                 2020                 2025             


Pro Tyr  Ser Ser Ala Ser Leu  Glu Ser Leu Asp Ser  Thr Ile Ser 
    2030                 2035                 2040             


Arg Arg  Asn Ala Ile Thr Ser  Trp Leu Trp Asp Leu  Thr Thr Ser 
    2045                 2050                 2055             


Leu Pro  Thr Thr Thr Trp Pro  Ser Thr Ser Leu Ser  Glu Ala Leu 
    2060                 2065                 2070             


Ser Ser  Gly His Ser Gly Val  Ser Asn Pro Ser Ser  Thr Thr Thr 
    2075                 2080                 2085             


Glu Phe  Pro Leu Phe Ser Ala  Ala Ser Thr Ser Ala  Ala Lys Gln 
    2090                 2095                 2100             


Arg Asn  Pro Glu Thr Glu Thr  His Gly Pro Gln Asn  Thr Ala Ala 
    2105                 2110                 2115             


Ser Thr  Leu Asn Thr Asp Ala  Ser Ser Val Thr Gly  Leu Ser Glu 
    2120                 2125                 2130             


Thr Pro  Val Gly Ala Ser Ile  Ser Ser Glu Val Pro  Leu Pro Met 
    2135                 2140                 2145             


Ala Ile  Thr Ser Arg Ser Asp  Val Ser Gly Leu Thr  Ser Glu Ser 
    2150                 2155                 2160             


Thr Ala  Asn Pro Ser Leu Gly  Thr Ala Ser Ser Ala  Gly Thr Lys 
    2165                 2170                 2175             


Leu Thr  Arg Thr Ile Ser Leu  Pro Thr Ser Glu Ser  Leu Val Ser 
    2180                 2185                 2190             


Phe Arg  Met Asn Lys Asp Pro  Trp Thr Val Ser Ile  Pro Leu Gly 
    2195                 2200                 2205             


Ser His  Pro Thr Thr Asn Thr  Glu Thr Ser Ile Pro  Val Asn Ser 
    2210                 2215                 2220             


Ala Gly  Pro Pro Gly Leu Ser  Thr Val Ala Ser Asp  Val Ile Asp 
    2225                 2230                 2235             


Thr Pro  Ser Asp Gly Ala Glu  Ser Ile Pro Thr Val  Ser Phe Ser 
    2240                 2245                 2250             


Pro Ser  Pro Asp Thr Glu Val  Thr Thr Ile Ser His  Phe Pro Glu 
    2255                 2260                 2265             


Lys Thr  Thr His Ser Phe Arg  Thr Ile Ser Ser Leu  Thr His Glu 
    2270                 2275                 2280             


Leu Thr  Ser Arg Val Thr Pro  Ile Pro Gly Asp Trp  Met Ser Ser 
    2285                 2290                 2295             


Ala Met  Ser Thr Lys Pro Thr  Gly Ala Ser Pro Ser  Ile Thr Leu 
    2300                 2305                 2310             


Gly Glu  Arg Arg Thr Ile Thr  Ser Ala Ala Pro Thr  Thr Ser Pro 
    2315                 2320                 2325             


Ile Val  Leu Thr Ala Ser Phe  Thr Glu Thr Ser Thr  Val Ser Leu 
    2330                 2335                 2340             


Asp Asn  Glu Thr Thr Val Lys  Thr Ser Asp Ile Leu  Asp Ala Arg 
    2345                 2350                 2355             


Lys Thr  Asn Glu Leu Pro Ser  Asp Ser Ser Ser Ser  Ser Asp Leu 
    2360                 2365                 2370             


Ile Asn  Thr Ser Ile Ala Ser  Ser Thr Met Asp Val  Thr Lys Thr 
    2375                 2380                 2385             


Ala Ser  Ile Ser Pro Thr Ser  Ile Ser Gly Met Thr  Ala Ser Ser 
    2390                 2395                 2400             


Ser Pro  Ser Leu Phe Ser Ser  Asp Arg Pro Gln Val  Pro Thr Ser 
    2405                 2410                 2415             


Thr Thr  Glu Thr Asn Thr Ala  Thr Ser Pro Ser Val  Ser Ser Asn 
    2420                 2425                 2430             


Thr Tyr  Ser Leu Asp Gly Gly  Ser Asn Val Gly Gly  Thr Pro Ser 
    2435                 2440                 2445             


Thr Leu  Pro Pro Phe Thr Ile  Thr His Pro Val Glu  Thr Ser Ser 
    2450                 2455                 2460             


Ala Leu  Leu Ala Trp Ser Arg  Pro Val Arg Thr Phe  Ser Thr Met 
    2465                 2470                 2475             


Val Ser  Thr Asp Thr Ala Ser  Gly Glu Asn Pro Thr  Ser Ser Asn 
    2480                 2485                 2490             


Ser Val  Val Thr Ser Val Pro  Ala Pro Gly Thr Trp  Thr Ser Val 
    2495                 2500                 2505             


Gly Ser  Thr Thr Asp Leu Pro  Ala Met Gly Phe Leu  Lys Thr Ser 
    2510                 2515                 2520             


Pro Ala  Gly Glu Ala His Ser  Leu Leu Ala Ser Thr  Ile Glu Pro 
    2525                 2530                 2535             


Ala Thr  Ala Phe Thr Pro His  Leu Ser Ala Ala Val  Val Thr Gly 
    2540                 2545                 2550             


Ser Ser  Ala Thr Ser Glu Ala  Ser Leu Leu Thr Thr  Ser Glu Ser 
    2555                 2560                 2565             


Lys Ala  Ile His Ser Ser Pro  Gln Thr Pro Thr Thr  Pro Thr Ser 
    2570                 2575                 2580             


Gly Ala  Asn Trp Glu Thr Ser  Ala Thr Pro Glu Ser  Leu Leu Val 
    2585                 2590                 2595             


Val Thr  Glu Thr Ser Asp Thr  Thr Leu Thr Ser Lys  Ile Leu Val 
    2600                 2605                 2610             


Thr Asp  Thr Ile Leu Phe Ser  Thr Val Ser Thr Pro  Pro Ser Lys 
    2615                 2620                 2625             


Phe Pro  Ser Thr Gly Thr Leu  Ser Gly Ala Ser Phe  Pro Thr Leu 
    2630                 2635                 2640             


Leu Pro  Asp Thr Pro Ala Ile  Pro Leu Thr Ala Thr  Glu Pro Thr 
    2645                 2650                 2655             


Ser Ser  Leu Ala Thr Ser Phe  Asp Ser Thr Pro Leu  Val Thr Ile 
    2660                 2665                 2670             


Ala Ser  Asp Ser Leu Gly Thr  Val Pro Glu Thr Thr  Leu Thr Met 
    2675                 2680                 2685             


Ser Glu  Thr Ser Asn Gly Asp  Ala Leu Val Leu Lys  Thr Val Ser 
    2690                 2695                 2700             


Asn Pro  Asp Arg Ser Ile Pro  Gly Ile Thr Ile Gln  Gly Val Thr 
    2705                 2710                 2715             


Glu Ser  Pro Leu His Pro Ser  Ser Thr Ser Pro Ser  Lys Ile Val 
    2720                 2725                 2730             


Ala Pro  Arg Asn Thr Thr Tyr  Glu Gly Ser Ile Thr  Val Ala Leu 
    2735                 2740                 2745             


Ser Thr  Leu Pro Ala Gly Thr  Thr Gly Ser Leu Val  Phe Ser Gln 
    2750                 2755                 2760             


Ser Ser  Glu Asn Ser Glu Thr  Thr Ala Leu Val Asp  Ser Ser Ala 
    2765                 2770                 2775             


Gly Leu  Glu Arg Ala Ser Val  Met Pro Leu Thr Thr  Gly Ser Gln 
    2780                 2785                 2790             


Gly Met  Ala Ser Ser Gly Gly  Ile Arg Ser Gly Ser  Thr His Ser 
    2795                 2800                 2805             


Thr Gly  Thr Lys Thr Phe Ser  Ser Leu Pro Leu Thr  Met Asn Pro 
    2810                 2815                 2820             


Gly Glu  Val Thr Ala Met Ser  Glu Ile Thr Thr Asn  Arg Leu Thr 
    2825                 2830                 2835             


Ala Thr  Gln Ser Thr Ala Pro  Lys Gly Ile Pro Val  Lys Pro Thr 
    2840                 2845                 2850             


Ser Ala  Glu Ser Gly Leu Leu  Thr Pro Val Ser Ala  Ser Ser Ser 
    2855                 2860                 2865             


Pro Ser  Lys Ala Phe Ala Ser  Leu Thr Thr Ala Pro  Pro Thr Trp 
    2870                 2875                 2880             


Gly Ile  Pro Gln Ser Thr Leu  Thr Phe Glu Phe Ser  Glu Val Pro 
    2885                 2890                 2895             


Ser Leu  Asp Thr Lys Ser Ala  Ser Leu Pro Thr Pro  Gly Gln Ser 
    2900                 2905                 2910             


Leu Asn  Thr Ile Pro Asp Ser  Asp Ala Ser Thr Ala  Ser Ser Ser 
    2915                 2920                 2925             


Leu Ser  Lys Ser Pro Glu Lys  Asn Pro Arg Ala Arg  Met Met Thr 
    2930                 2935                 2940             


Ser Thr  Lys Ala Ile Ser Ala  Ser Ser Phe Gln Ser  Thr Gly Phe 
    2945                 2950                 2955             


Thr Glu  Thr Pro Glu Gly Ser  Ala Ser Pro Ser Met  Ala Gly His 
    2960                 2965                 2970             


Glu Pro  Arg Val Pro Thr Ser  Gly Thr Gly Asp Pro  Arg Tyr Ala 
    2975                 2980                 2985             


Ser Glu  Ser Met Ser Tyr Pro  Asp Pro Ser Lys Ala  Ser Ser Ala 
    2990                 2995                 3000             


Met Thr  Ser Thr Ser Leu Ala  Ser Lys Leu Thr Thr  Leu Phe Ser 
    3005                 3010                 3015             


Thr Gly  Gln Ala Ala Arg Ser  Gly Ser Ser Ser Ser  Pro Ile Ser 
    3020                 3025                 3030             


Leu Ser  Thr Glu Lys Glu Thr  Ser Phe Leu Ser Pro  Thr Ala Ser 
    3035                 3040                 3045             


Thr Ser  Arg Lys Thr Ser Leu  Phe Leu Gly Pro Ser  Met Ala Arg 
    3050                 3055                 3060             


Gln Pro  Asn Ile Leu Val His  Leu Gln Thr Ser Ala  Leu Thr Leu 
    3065                 3070                 3075             


Ser Pro  Thr Ser Thr Leu Asn  Met Ser Gln Glu Glu  Pro Pro Glu 
    3080                 3085                 3090             


Leu Thr  Ser Ser Gln Thr Ile  Ala Glu Glu Glu Gly  Thr Thr Ala 
    3095                 3100                 3105             


Glu Thr  Gln Thr Leu Thr Phe  Thr Pro Ser Glu Thr  Pro Thr Ser 
    3110                 3115                 3120             


Leu Leu  Pro Val Ser Ser Pro  Thr Glu Pro Thr Ala  Arg Arg Lys 
    3125                 3130                 3135             


Ser Ser  Pro Glu Thr Trp Ala  Ser Ser Ile Ser Val  Pro Ala Lys 
    3140                 3145                 3150             


Thr Ser  Leu Val Glu Thr Thr  Asp Gly Thr Leu Val  Thr Thr Ile 
    3155                 3160                 3165             


Lys Met  Ser Ser Gln Ala Ala  Gln Gly Asn Ser Thr  Trp Pro Ala 
    3170                 3175                 3180             


Pro Ala  Glu Glu Thr Gly Ser  Ser Pro Ala Gly Thr  Ser Pro Gly 
    3185                 3190                 3195             


Ser Pro  Glu Met Ser Thr Thr  Leu Lys Ile Met Ser  Ser Lys Glu 
    3200                 3205                 3210             


Pro Ser  Ile Ser Pro Glu Ile  Arg Ser Thr Val Arg  Asn Ser Pro 
    3215                 3220                 3225             


Trp Lys  Thr Pro Glu Thr Thr  Val Pro Met Glu Thr  Thr Val Glu 
    3230                 3235                 3240             


Pro Val  Thr Leu Gln Ser Thr  Ala Leu Gly Ser Gly  Ser Thr Ser 
    3245                 3250                 3255             


Ile Ser  His Leu Pro Thr Gly  Thr Thr Ser Pro Thr  Lys Ser Pro 
    3260                 3265                 3270             


Thr Glu  Asn Met Leu Ala Thr  Glu Arg Val Ser Leu  Ser Pro Ser 
    3275                 3280                 3285             


Pro Pro  Glu Ala Trp Thr Asn  Leu Tyr Ser Gly Thr  Pro Gly Gly 
    3290                 3295                 3300             


Thr Arg  Gln Ser Leu Ala Thr  Met Ser Ser Val Ser  Leu Glu Ser 
    3305                 3310                 3315             


Pro Thr  Ala Arg Ser Ile Thr  Gly Thr Gly Gln Gln  Ser Ser Pro 
    3320                 3325                 3330             


Glu Leu  Val Ser Lys Thr Thr  Gly Met Glu Phe Ser  Met Trp His 
    3335                 3340                 3345             


Gly Ser  Thr Gly Gly Thr Thr  Gly Asp Thr His Val  Ser Leu Ser 
    3350                 3355                 3360             


Thr Ser  Ser Asn Ile Leu Glu  Asp Pro Val Thr Ser  Pro Asn Ser 
    3365                 3370                 3375             


Val Ser  Ser Leu Thr Asp Lys  Ser Lys His Lys Thr  Glu Thr Trp 
    3380                 3385                 3390             


Val Ser  Thr Thr Ala Ile Pro  Ser Thr Val Leu Asn  Asn Lys Ile 
    3395                 3400                 3405             


Met Ala  Ala Glu Gln Gln Thr  Ser Arg Ser Val Asp  Glu Ala Tyr 
    3410                 3415                 3420             


Ser Ser  Thr Ser Ser Trp Ser  Asp Gln Thr Ser Gly  Ser Asp Ile 
    3425                 3430                 3435             


Thr Leu  Gly Ala Ser Pro Asp  Val Thr Asn Thr Leu  Tyr Ile Thr 
    3440                 3445                 3450             


Ser Thr  Ala Gln Thr Thr Ser  Leu Val Ser Leu Pro  Ser Gly Asp 
    3455                 3460                 3465             


Gln Gly  Ile Thr Ser Leu Thr  Asn Pro Ser Gly Gly  Lys Thr Ser 
    3470                 3475                 3480             


Ser Ala  Ser Ser Val Thr Ser  Pro Ser Ile Gly Leu  Glu Thr Leu 
    3485                 3490                 3495             


Arg Ala  Asn Val Ser Ala Val  Lys Ser Asp Ile Ala  Pro Thr Ala 
    3500                 3505                 3510             


Gly His  Leu Ser Gln Thr Ser  Ser Pro Ala Glu Val  Ser Ile Leu 
    3515                 3520                 3525             


Asp Val  Thr Thr Ala Pro Thr  Pro Gly Ile Ser Thr  Thr Ile Thr 
    3530                 3535                 3540             


Thr Met  Gly Thr Asn Ser Ile  Ser Thr Thr Thr Pro  Asn Pro Glu 
    3545                 3550                 3555             


Val Gly  Met Ser Thr Met Asp  Ser Thr Pro Ala Thr  Glu Arg Arg 
    3560                 3565                 3570             


Thr Thr  Ser Thr Glu His Pro  Ser Thr Trp Ser Ser  Thr Ala Ala 
    3575                 3580                 3585             


Ser Asp  Ser Trp Thr Val Thr  Asp Met Thr Ser Asn  Leu Lys Val 
    3590                 3595                 3600             


Ala Arg  Ser Pro Gly Thr Ile  Ser Thr Met His Thr  Thr Ser Phe 
    3605                 3610                 3615             


Leu Ala  Ser Ser Thr Glu Leu  Asp Ser Met Ser Thr  Pro His Gly 
    3620                 3625                 3630             


Arg Ile  Thr Val Ile Gly Thr  Ser Leu Val Thr Pro  Ser Ser Asp 
    3635                 3640                 3645             


Ala Ser  Ala Val Lys Thr Glu  Thr Ser Thr Ser Glu  Arg Thr Leu 
    3650                 3655                 3660             


Ser Pro  Ser Asp Thr Thr Ala  Ser Thr Pro Ile Ser  Thr Phe Ser 
    3665                 3670                 3675             


Arg Val  Gln Arg Met Ser Ile  Ser Val Pro Asp Ile  Leu Ser Thr 
    3680                 3685                 3690             


Ser Trp  Thr Pro Ser Ser Thr  Glu Ala Glu Asp Val  Pro Val Ser 
    3695                 3700                 3705             


Met Val  Ser Thr Asp His Ala  Ser Thr Lys Thr Asp  Pro Asn Thr 
    3710                 3715                 3720             


Pro Leu  Ser Thr Phe Leu Phe  Asp Ser Leu Ser Thr  Leu Asp Trp 
    3725                 3730                 3735             


Asp Thr  Gly Arg Ser Leu Ser  Ser Ala Thr Ala Thr  Thr Ser Ala 
    3740                 3745                 3750             


Pro Gln  Gly Ala Thr Thr Pro  Gln Glu Leu Thr Leu  Glu Thr Met 
    3755                 3760                 3765             


Ile Ser  Pro Ala Thr Ser Gln  Leu Pro Phe Ser Ile  Gly His Ile 
    3770                 3775                 3780             


Thr Ser  Ala Val Thr Pro Ala  Ala Met Ala Arg Ser  Ser Gly Val 
    3785                 3790                 3795             


Thr Phe  Ser Arg Pro Asp Pro  Thr Ser Lys Lys Ala  Glu Gln Thr 
    3800                 3805                 3810             


Ser Thr  Gln Leu Pro Thr Thr  Thr Ser Ala His Pro  Gly Gln Val 
    3815                 3820                 3825             


Pro Arg  Ser Ala Ala Thr Thr  Leu Asp Val Ile Pro  His Thr Ala 
    3830                 3835                 3840             


Lys Thr  Pro Asp Ala Thr Phe  Gln Arg Gln Gly Gln  Thr Ala Leu 
    3845                 3850                 3855             


Thr Thr  Glu Ala Arg Ala Thr  Ser Asp Ser Trp Asn  Glu Lys Glu 
    3860                 3865                 3870             


Lys Ser  Thr Pro Ser Ala Pro  Trp Ile Thr Glu Met  Met Asn Ser 
    3875                 3880                 3885             


Val Ser  Glu Asp Thr Ile Lys  Glu Val Thr Ser Ser  Ser Ser Val 
    3890                 3895                 3900             


Leu Arg  Thr Leu Asn Thr Leu  Asp Ile Asn Leu Glu  Ser Gly Thr 
    3905                 3910                 3915             


Thr Ser  Ser Pro Ser Trp Lys  Ser Ser Pro Tyr Glu  Arg Ile Ala 
    3920                 3925                 3930             


Pro Ser  Glu Ser Thr Thr Asp  Lys Glu Ala Ile His  Pro Ser Thr 
    3935                 3940                 3945             


Asn Thr  Val Glu Thr Thr Gly  Trp Val Thr Ser Ser  Glu His Ala 
    3950                 3955                 3960             


Ser His  Ser Thr Ile Pro Ala  His Ser Ala Ser Ser  Lys Leu Thr 
    3965                 3970                 3975             


Ser Pro  Val Val Thr Thr Ser  Thr Arg Glu Gln Ala  Ile Val Ser 
    3980                 3985                 3990             


Met Ser  Thr Thr Thr Trp Pro  Glu Ser Thr Arg Ala  Arg Thr Glu 
    3995                 4000                 4005             


Pro Asn  Ser Phe Leu Thr Ile  Glu Leu Arg Asp Val  Ser Pro Tyr 
    4010                 4015                 4020             


Met Asp  Thr Ser Ser Thr Thr  Gln Thr Ser Ile Ile  Ser Ser Pro 
    4025                 4030                 4035             


Gly Ser  Thr Ala Ile Thr Lys  Gly Pro Arg Thr Glu  Ile Thr Ser 
    4040                 4045                 4050             


Ser Lys  Arg Ile Ser Ser Ser  Phe Leu Ala Gln Ser  Met Arg Ser 
    4055                 4060                 4065             


Ser Asp  Ser Pro Ser Glu Ala  Ile Thr Arg Leu Ser  Asn Phe Pro 
    4070                 4075                 4080             


Ala Met  Thr Glu Ser Gly Gly  Met Ile Leu Ala Met  Gln Thr Ser 
    4085                 4090                 4095             


Pro Pro  Gly Ala Thr Ser Leu  Ser Ala Pro Thr Leu  Asp Thr Ser 
    4100                 4105                 4110             


Ala Thr  Ala Ser Trp Thr Gly  Thr Pro Leu Ala Thr  Thr Gln Arg 
    4115                 4120                 4125             


Phe Thr  Tyr Ser Glu Lys Thr  Thr Leu Phe Ser Lys  Gly Pro Glu 
    4130                 4135                 4140             


Asp Thr  Ser Gln Pro Ser Pro  Pro Ser Val Glu Glu  Thr Ser Ser 
    4145                 4150                 4155             


Ser Ser  Ser Leu Val Pro Ile  His Ala Thr Thr Ser  Pro Ser Asn 
    4160                 4165                 4170             


Ile Leu  Leu Thr Ser Gln Gly  His Ser Pro Ser Ser  Thr Pro Pro 
    4175                 4180                 4185             


Val Thr  Ser Val Phe Leu Ser  Glu Thr Ser Gly Leu  Gly Lys Thr 
    4190                 4195                 4200             


Thr Asp  Met Ser Arg Ile Ser  Leu Glu Pro Gly Thr  Ser Leu Pro 
    4205                 4210                 4215             


Pro Asn  Leu Ser Ser Thr Ala  Gly Glu Ala Leu Ser  Thr Tyr Glu 
    4220                 4225                 4230             


Ala Ser  Arg Asp Thr Lys Ala  Ile His His Ser Ala  Asp Thr Ala 
    4235                 4240                 4245             


Val Thr  Asn Met Glu Ala Thr  Ser Ser Glu Tyr Ser  Pro Ile Pro 
    4250                 4255                 4260             


Gly His  Thr Lys Pro Ser Lys  Ala Thr Ser Pro Leu  Val Thr Ser 
    4265                 4270                 4275             


His Ile  Met Gly Asp Ile Thr  Ser Ser Thr Ser Val  Phe Gly Ser 
    4280                 4285                 4290             


Ser Glu  Thr Thr Glu Ile Glu  Thr Val Ser Ser Val  Asn Gln Gly 
    4295                 4300                 4305             


Leu Gln  Glu Arg Ser Thr Ser  Gln Val Ala Ser Ser  Ala Thr Glu 
    4310                 4315                 4320             


Thr Ser  Thr Val Ile Thr His  Val Ser Ser Gly Asp  Ala Thr Thr 
    4325                 4330                 4335             


His Val  Thr Lys Thr Gln Ala  Thr Phe Ser Ser Gly  Thr Ser Ile 
    4340                 4345                 4350             


Ser Ser  Pro His Gln Phe Ile  Thr Ser Thr Asn Thr  Phe Thr Asp 
    4355                 4360                 4365             


Val Ser  Thr Asn Pro Ser Thr  Ser Leu Ile Met Thr  Glu Ser Ser 
    4370                 4375                 4380             


Gly Val  Thr Ile Thr Thr Gln  Thr Gly Pro Thr Gly  Ala Ala Thr 
    4385                 4390                 4395             


Gln Gly  Pro Tyr Leu Leu Asp  Thr Ser Thr Met Pro  Tyr Leu Thr 
    4400                 4405                 4410             


Glu Thr  Pro Leu Ala Val Thr  Pro Asp Phe Met Gln  Ser Glu Lys 
    4415                 4420                 4425             


Thr Thr  Leu Ile Ser Lys Gly  Pro Lys Asp Val Ser  Trp Thr Ser 
    4430                 4435                 4440             


Pro Pro  Ser Val Ala Glu Thr  Ser Tyr Pro Ser Ser  Leu Thr Pro 
    4445                 4450                 4455             


Phe Leu  Val Thr Thr Ile Pro  Pro Ala Thr Ser Thr  Leu Gln Gly 
    4460                 4465                 4470             


Gln His  Thr Ser Ser Pro Val  Ser Ala Thr Ser Val  Leu Thr Ser 
    4475                 4480                 4485             


Gly Leu  Val Lys Thr Thr Asp  Met Leu Asn Thr Ser  Met Glu Pro 
    4490                 4495                 4500             


Val Thr  Asn Ser Pro Gln Asn  Leu Asn Asn Pro Ser  Asn Glu Ile 
    4505                 4510                 4515             


Leu Ala  Thr Leu Ala Ala Thr  Thr Asp Ile Glu Thr  Ile His Pro 
    4520                 4525                 4530             


Ser Ile  Asn Lys Ala Val Thr  Asn Met Gly Thr Ala  Ser Ser Ala 
    4535                 4540                 4545             


His Val  Leu His Ser Thr Leu  Pro Val Ser Ser Glu  Pro Ser Thr 
    4550                 4555                 4560             


Ala Thr  Ser Pro Met Val Pro  Ala Ser Ser Met Gly  Asp Ala Leu 
    4565                 4570                 4575             


Ala Ser  Ile Ser Ile Pro Gly  Ser Glu Thr Thr Asp  Ile Glu Gly 
    4580                 4585                 4590             


Glu Pro  Thr Ser Ser Leu Thr  Ala Gly Arg Lys Glu  Asn Ser Thr 
    4595                 4600                 4605             


Leu Gln  Glu Met Asn Ser Thr  Thr Glu Ser Asn Ile  Ile Leu Ser 
    4610                 4615                 4620             


Asn Val  Ser Val Gly Ala Ile  Thr Glu Ala Thr Lys  Met Glu Val 
    4625                 4630                 4635             


Pro Ser  Phe Asp Ala Thr Phe  Ile Pro Thr Pro Ala  Gln Ser Thr 
    4640                 4645                 4650             


Lys Phe  Pro Asp Ile Phe Ser  Val Ala Ser Ser Arg  Leu Ser Asn 
    4655                 4660                 4665             


Ser Pro  Pro Met Thr Ile Ser  Thr His Met Thr Thr  Thr Gln Thr 
    4670                 4675                 4680             


Gly Ser  Ser Gly Ala Thr Ser  Lys Ile Pro Leu Ala  Leu Asp Thr 
    4685                 4690                 4695             


Ser Thr  Leu Glu Thr Ser Ala  Gly Thr Pro Ser Val  Val Thr Glu 
    4700                 4705                 4710             


Gly Phe  Ala His Ser Lys Ile  Thr Thr Ala Met Asn  Asn Asp Val 
    4715                 4720                 4725             


Lys Asp  Val Ser Gln Thr Asn  Pro Pro Phe Gln Asp  Glu Ala Ser 
    4730                 4735                 4740             


Ser Pro  Ser Ser Gln Ala Pro  Val Leu Val Thr Thr  Leu Pro Ser 
    4745                 4750                 4755             


Ser Val  Ala Phe Thr Pro Gln  Trp His Ser Thr Ser  Ser Pro Val 
    4760                 4765                 4770             


Ser Met  Ser Ser Val Leu Thr  Ser Ser Leu Val Lys  Thr Ala Gly 
    4775                 4780                 4785             


Lys Val  Asp Thr Ser Leu Glu  Thr Val Thr Ser Ser  Pro Gln Ser 
    4790                 4795                 4800             


Met Ser  Asn Thr Leu Asp Asp  Ile Ser Val Thr Ser  Ala Ala Thr 
    4805                 4810                 4815             


Thr Asp  Ile Glu Thr Thr His  Pro Ser Ile Asn Thr  Val Val Thr 
    4820                 4825                 4830             


Asn Val  Gly Thr Thr Gly Ser  Ala Phe Glu Ser His  Ser Thr Val 
    4835                 4840                 4845             


Ser Ala  Tyr Pro Glu Pro Ser  Lys Val Thr Ser Pro  Asn Val Thr 
    4850                 4855                 4860             


Thr Ser  Thr Met Glu Asp Thr  Thr Ile Ser Arg Ser  Ile Pro Lys 
    4865                 4870                 4875             


Ser Ser  Lys Thr Thr Arg Thr  Glu Thr Glu Thr Thr  Ser Ser Leu 
    4880                 4885                 4890             


Thr Pro  Lys Leu Arg Glu Thr  Ser Ile Ser Gln Glu  Ile Thr Ser 
    4895                 4900                 4905             


Ser Thr  Glu Thr Ser Thr Val  Pro Tyr Lys Glu Leu  Thr Gly Ala 
    4910                 4915                 4920             


Thr Thr  Glu Val Ser Arg Thr  Asp Val Thr Ser Ser  Ser Ser Thr 
    4925                 4930                 4935             


Ser Phe  Pro Gly Pro Asp Gln  Ser Thr Val Ser Leu  Asp Ile Ser 
    4940                 4945                 4950             


Thr Glu  Thr Asn Thr Arg Leu  Ser Thr Ser Pro Ile  Met Thr Glu 
    4955                 4960                 4965             


Ser Ala  Glu Ile Thr Ile Thr  Thr Gln Thr Gly Pro  His Gly Ala 
    4970                 4975                 4980             


Thr Ser  Gln Asp Thr Phe Thr  Met Asp Pro Ser Asn  Thr Thr Pro 
    4985                 4990                 4995             


Gln Ala  Gly Ile His Ser Ala  Met Thr His Gly Phe  Ser Gln Leu 
    5000                 5005                 5010             


Asp Val  Thr Thr Leu Met Ser  Arg Ile Pro Gln Asp  Val Ser Trp 
    5015                 5020                 5025             


Thr Ser  Pro Pro Ser Val Asp  Lys Thr Ser Ser Pro  Ser Ser Phe 
    5030                 5035                 5040             


Leu Ser  Ser Pro Ala Met Thr  Thr Pro Ser Leu Ile  Ser Ser Thr 
    5045                 5050                 5055             


Leu Pro  Glu Asp Lys Leu Ser  Ser Pro Met Thr Ser  Leu Leu Thr 
    5060                 5065                 5070             


Ser Gly  Leu Val Lys Ile Thr  Asp Ile Leu Arg Thr  Arg Leu Glu 
    5075                 5080                 5085             


Pro Val  Thr Ser Ser Leu Pro  Asn Phe Ser Ser Thr  Ser Asp Lys 
    5090                 5095                 5100             


Ile Leu  Ala Thr Ser Lys Asp  Ser Lys Asp Thr Lys  Glu Ile Phe 
    5105                 5110                 5115             


Pro Ser  Ile Asn Thr Glu Glu  Thr Asn Val Lys Ala  Asn Asn Ser 
    5120                 5125                 5130             


Gly His  Glu Ser His Ser Pro  Ala Leu Ala Asp Ser  Glu Thr Pro 
    5135                 5140                 5145             


Lys Ala  Thr Thr Gln Met Val  Ile Thr Thr Thr Val  Gly Asp Pro 
    5150                 5155                 5160             


Ala Pro  Ser Thr Ser Met Pro  Val His Gly Ser Ser  Glu Thr Thr 
    5165                 5170                 5175             


Asn Ile  Lys Arg Glu Pro Thr  Tyr Phe Leu Thr Pro  Arg Leu Arg 
    5180                 5185                 5190             


Glu Thr  Ser Thr Ser Gln Glu  Ser Ser Phe Pro Thr  Asp Thr Ser 
    5195                 5200                 5205             


Phe Leu  Leu Ser Lys Val Pro  Thr Gly Thr Ile Thr  Glu Val Ser 
    5210                 5215                 5220             


Ser Thr  Gly Val Asn Ser Ser  Ser Lys Ile Ser Thr  Pro Asp His 
    5225                 5230                 5235             


Asp Lys  Ser Thr Val Pro Pro  Asp Thr Phe Thr Gly  Glu Ile Pro 
    5240                 5245                 5250             


Arg Val  Phe Thr Ser Ser Ile  Lys Thr Lys Ser Ala  Glu Met Thr 
    5255                 5260                 5265             


Ile Thr  Thr Gln Ala Ser Pro  Pro Glu Ser Ala Ser  His Ser Thr 
    5270                 5275                 5280             


Leu Pro  Leu Asp Thr Ser Thr  Thr Leu Ser Gln Gly  Gly Thr His 
    5285                 5290                 5295             


Ser Thr  Val Thr Gln Gly Phe  Pro Tyr Ser Glu Val  Thr Thr Leu 
    5300                 5305                 5310             


Met Gly  Met Gly Pro Gly Asn  Val Ser Trp Met Thr  Thr Pro Pro 
    5315                 5320                 5325             


Val Glu  Glu Thr Ser Ser Val  Ser Ser Leu Met Ser  Ser Pro Ala 
    5330                 5335                 5340             


Met Thr  Ser Pro Ser Pro Val  Ser Ser Thr Ser Pro  Gln Ser Ile 
    5345                 5350                 5355             


Pro Ser  Ser Pro Leu Pro Val  Thr Ala Leu Pro Thr  Ser Val Leu 
    5360                 5365                 5370             


Val Thr  Thr Thr Asp Val Leu  Gly Thr Thr Ser Pro  Glu Ser Val 
    5375                 5380                 5385             


Thr Ser  Ser Pro Pro Asn Leu  Ser Ser Ile Thr His  Glu Arg Pro 
    5390                 5395                 5400             


Ala Thr  Tyr Lys Asp Thr Ala  His Thr Glu Ala Ala  Met His His 
    5405                 5410                 5415             


Ser Thr  Asn Thr Ala Val Thr  Asn Val Gly Thr Ser  Gly Ser Gly 
    5420                 5425                 5430             


His Lys  Ser Gln Ser Ser Val  Leu Ala Asp Ser Glu  Thr Ser Lys 
    5435                 5440                 5445             


Ala Thr  Pro Leu Met Ser Thr  Thr Ser Thr Leu Gly  Asp Thr Ser 
    5450                 5455                 5460             


Val Ser  Thr Ser Thr Pro Asn  Ile Ser Gln Thr Asn  Gln Ile Gln 
    5465                 5470                 5475             


Thr Glu  Pro Thr Ala Ser Leu  Ser Pro Arg Leu Arg  Glu Ser Ser 
    5480                 5485                 5490             


Thr Ser  Glu Lys Thr Ser Ser  Thr Thr Glu Thr Asn  Thr Ala Phe 
    5495                 5500                 5505             


Ser Tyr  Val Pro Thr Gly Ala  Ile Thr Gln Ala Ser  Arg Thr Glu 
    5510                 5515                 5520             


Ile Ser  Ser Ser Arg Thr Ser  Ile Ser Asp Leu Asp  Arg Pro Thr 
    5525                 5530                 5535             


Ile Ala  Pro Asp Ile Ser Thr  Gly Met Ile Thr Arg  Leu Phe Thr 
    5540                 5545                 5550             


Ser Pro  Ile Met Thr Lys Ser  Ala Glu Met Thr Val  Thr Thr Gln 
    5555                 5560                 5565             


Thr Thr  Thr Pro Gly Ala Thr  Ser Gln Gly Ile Leu  Pro Trp Asp 
    5570                 5575                 5580             


Thr Ser  Thr Thr Leu Phe Gln  Gly Gly Thr His Ser  Thr Val Ser 
    5585                 5590                 5595             


Gln Gly  Phe Pro His Ser Glu  Ile Thr Thr Leu Arg  Ser Arg Thr 
    5600                 5605                 5610             


Pro Gly  Asp Val Ser Trp Met  Thr Thr Pro Pro Val  Glu Glu Thr 
    5615                 5620                 5625             


Ser Ser  Gly Phe Ser Leu Met  Ser Pro Ser Met Thr  Ser Pro Ser 
    5630                 5635                 5640             


Pro Val  Ser Ser Thr Ser Pro  Glu Ser Ile Pro Ser  Ser Pro Leu 
    5645                 5650                 5655             


Pro Val  Thr Ala Leu Leu Thr  Ser Val Leu Val Thr  Thr Thr Asn 
    5660                 5665                 5670             


Val Leu  Gly Thr Thr Ser Pro  Glu Pro Val Thr Ser  Ser Pro Pro 
    5675                 5680                 5685             


Asn Leu  Ser Ser Pro Thr Gln  Glu Arg Leu Thr Thr  Tyr Lys Asp 
    5690                 5695                 5700             


Thr Ala  His Thr Glu Ala Met  His Ala Ser Met His  Thr Asn Thr 
    5705                 5710                 5715             


Ala Val  Ala Asn Val Gly Thr  Ser Ile Ser Gly His  Glu Ser Gln 
    5720                 5725                 5730             


Ser Ser  Val Pro Ala Asp Ser  His Thr Ser Lys Ala  Thr Ser Pro 
    5735                 5740                 5745             


Met Gly  Ile Thr Phe Ala Met  Gly Asp Thr Ser Val  Ser Thr Ser 
    5750                 5755                 5760             


Thr Pro  Ala Phe Phe Glu Thr  Arg Ile Gln Thr Glu  Ser Thr Ser 
    5765                 5770                 5775             


Ser Leu  Ile Pro Gly Leu Arg  Asp Thr Arg Thr Ser  Glu Glu Ile 
    5780                 5785                 5790             


Asn Thr  Val Thr Glu Thr Ser  Thr Val Leu Ser Glu  Val Pro Thr 
    5795                 5800                 5805             


Thr Thr  Thr Thr Glu Val Ser  Arg Thr Glu Val Ile  Thr Ser Ser 
    5810                 5815                 5820             


Arg Thr  Thr Ile Ser Gly Pro  Asp His Ser Lys Met  Ser Pro Tyr 
    5825                 5830                 5835             


Ile Ser  Thr Glu Thr Ile Thr  Arg Leu Ser Thr Phe  Pro Phe Val 
    5840                 5845                 5850             


Thr Gly  Ser Thr Glu Met Ala  Ile Thr Asn Gln Thr  Gly Pro Ile 
    5855                 5860                 5865             


Gly Thr  Ile Ser Gln Ala Thr  Leu Thr Leu Asp Thr  Ser Ser Thr 
    5870                 5875                 5880             


Ala Ser  Trp Glu Gly Thr His  Ser Pro Val Thr Gln  Arg Phe Pro 
    5885                 5890                 5895             


His Ser  Glu Glu Thr Thr Thr  Met Ser Arg Ser Thr  Lys Gly Val 
    5900                 5905                 5910             


Ser Trp  Gln Ser Pro Pro Ser  Val Glu Glu Thr Ser  Ser Pro Ser 
    5915                 5920                 5925             


Ser Pro  Val Pro Leu Pro Ala  Ile Thr Ser His Ser  Ser Leu Tyr 
    5930                 5935                 5940             


Ser Ala  Val Ser Gly Ser Ser  Pro Thr Ser Ala Leu  Pro Val Thr 
    5945                 5950                 5955             


Ser Leu  Leu Thr Ser Gly Arg  Arg Lys Thr Ile Asp  Met Leu Asp 
    5960                 5965                 5970             


Thr His  Ser Glu Leu Val Thr  Ser Ser Leu Pro Ser  Ala Ser Ser 
    5975                 5980                 5985             


Phe Ser  Gly Glu Ile Leu Thr  Ser Glu Ala Ser Thr  Asn Thr Glu 
    5990                 5995                 6000             


Thr Ile  His Phe Ser Glu Asn  Thr Ala Glu Thr Asn  Met Gly Thr 
    6005                 6010                 6015             


Thr Asn  Ser Met His Lys Leu  His Ser Ser Val Ser  Ile His Ser 
    6020                 6025                 6030             


Gln Pro  Ser Gly His Thr Pro  Pro Lys Val Thr Gly  Ser Met Met 
    6035                 6040                 6045             


Glu Asp  Ala Ile Val Ser Thr  Ser Thr Pro Gly Ser  Pro Glu Thr 
    6050                 6055                 6060             


Lys Asn  Val Asp Arg Asp Ser  Thr Ser Pro Leu Thr  Pro Glu Leu 
    6065                 6070                 6075             


Lys Glu  Asp Ser Thr Ala Leu  Val Met Asn Ser Thr  Thr Glu Ser 
    6080                 6085                 6090             


Asn Thr  Val Phe Ser Ser Val  Ser Leu Asp Ala Ala  Thr Glu Val 
    6095                 6100                 6105             


Ser Arg  Ala Glu Val Thr Tyr  Tyr Asp Pro Thr Phe  Met Pro Ala 
    6110                 6115                 6120             


Ser Ala  Gln Ser Thr Lys Ser  Pro Asp Ile Ser Pro  Glu Ala Ser 
    6125                 6130                 6135             


Ser Ser  His Ser Asn Ser Pro  Pro Leu Thr Ile Ser  Thr His Lys 
    6140                 6145                 6150             


Thr Ile  Ala Thr Gln Thr Gly  Pro Ser Gly Val Thr  Ser Leu Gly 
    6155                 6160                 6165             


Gln Leu  Thr Leu Asp Thr Ser  Thr Ile Ala Thr Ser  Ala Gly Thr 
    6170                 6175                 6180             


Pro Ser  Ala Arg Thr Gln Asp  Phe Val Asp Ser Glu  Thr Thr Ser 
    6185                 6190                 6195             


Val Met  Asn Asn Asp Leu Asn  Asp Val Leu Lys Thr  Ser Pro Phe 
    6200                 6205                 6210             


Ser Ala  Glu Glu Ala Asn Ser  Leu Ser Ser Gln Ala  Pro Leu Leu 
    6215                 6220                 6225             


Val Thr  Thr Ser Pro Ser Pro  Val Thr Ser Thr Leu  Gln Glu His 
    6230                 6235                 6240             


Ser Thr  Ser Ser Leu Val Ser  Val Thr Ser Val Pro  Thr Pro Thr 
    6245                 6250                 6255             


Leu Ala  Lys Ile Thr Asp Met  Asp Thr Asn Leu Glu  Pro Val Thr 
    6260                 6265                 6270             


Arg Ser  Pro Gln Asn Leu Arg  Asn Thr Leu Ala Thr  Ser Glu Ala 
    6275                 6280                 6285             


Thr Thr  Asp Thr His Thr Met  His Pro Ser Ile Asn  Thr Ala Val 
    6290                 6295                 6300             


Ala Asn  Val Gly Thr Thr Ser  Ser Pro Asn Glu Phe  Tyr Phe Thr 
    6305                 6310                 6315             


Val Ser  Pro Asp Ser Asp Pro  Tyr Lys Ala Thr Ser  Ala Val Val 
    6320                 6325                 6330             


Ile Thr  Ser Thr Ser Gly Asp  Ser Ile Val Ser Thr  Ser Met Pro 
    6335                 6340                 6345             


Arg Ser  Ser Ala Met Lys Lys  Ile Glu Ser Glu Thr  Thr Phe Ser 
    6350                 6355                 6360             


Leu Ile  Phe Arg Leu Arg Glu  Thr Ser Thr Ser Gln  Lys Ile Gly 
    6365                 6370                 6375             


Ser Ser  Ser Asp Thr Ser Thr  Val Phe Asp Lys Ala  Phe Thr Ala 
    6380                 6385                 6390             


Ala Thr  Thr Glu Val Ser Arg  Thr Glu Leu Thr Ser  Ser Ser Arg 
    6395                 6400                 6405             


Thr Ser  Ile Gln Gly Thr Glu  Lys Pro Thr Met Ser  Pro Asp Thr 
    6410                 6415                 6420             


Ser Thr  Arg Ser Val Thr Met  Leu Ser Thr Phe Ala  Gly Leu Thr 
    6425                 6430                 6435             


Lys Ser  Glu Glu Arg Thr Ile  Ala Thr Gln Thr Gly  Pro His Arg 
    6440                 6445                 6450             


Ala Thr  Ser Gln Gly Thr Leu  Thr Trp Asp Thr Ser  Ile Thr Thr 
    6455                 6460                 6465             


Ser Gln  Ala Gly Thr His Ser  Ala Met Thr His Gly  Phe Ser Gln 
    6470                 6475                 6480             


Leu Asp  Leu Ser Thr Leu Thr  Ser Arg Val Pro Glu  Tyr Ile Ser 
    6485                 6490                 6495             


Gly Thr  Ser Pro Pro Ser Val  Glu Lys Thr Ser Ser  Ser Ser Ser 
    6500                 6505                 6510             


Leu Leu  Ser Leu Pro Ala Ile  Thr Ser Pro Ser Pro  Val Pro Thr 
    6515                 6520                 6525             


Thr Leu  Pro Glu Ser Arg Pro  Ser Ser Pro Val His  Leu Thr Ser 
    6530                 6535                 6540             


Leu Pro  Thr Ser Gly Leu Val  Lys Thr Thr Asp Met  Leu Ala Ser 
    6545                 6550                 6555             


Val Ala  Ser Leu Pro Pro Asn  Leu Gly Ser Thr Ser  His Lys Ile 
    6560                 6565                 6570             


Pro Thr  Thr Ser Glu Asp Ile  Lys Asp Thr Glu Lys  Met Tyr Pro 
    6575                 6580                 6585             


Ser Thr  Asn Ile Ala Val Thr  Asn Val Gly Thr Thr  Thr Ser Glu 
    6590                 6595                 6600             


Lys Glu  Ser Tyr Ser Ser Val  Pro Ala Tyr Ser Glu  Pro Pro Lys 
    6605                 6610                 6615             


Val Thr  Ser Pro Met Val Thr  Ser Phe Asn Ile Arg  Asp Thr Ile 
    6620                 6625                 6630             


Val Ser  Thr Ser Met Pro Gly  Ser Ser Glu Ile Thr  Arg Ile Glu 
    6635                 6640                 6645             


Met Glu  Ser Thr Phe Ser Leu  Ala His Gly Leu Lys  Gly Thr Ser 
    6650                 6655                 6660             


Thr Ser  Gln Asp Pro Ile Val  Ser Thr Glu Lys Ser  Ala Val Leu 
    6665                 6670                 6675             


His Lys  Leu Thr Thr Gly Ala  Thr Glu Thr Ser Arg  Thr Glu Val 
    6680                 6685                 6690             


Ala Ser  Ser Arg Arg Thr Ser  Ile Pro Gly Pro Asp  His Ser Thr 
    6695                 6700                 6705             


Glu Ser  Pro Asp Ile Ser Thr  Glu Val Ile Pro Ser  Leu Pro Ile 
    6710                 6715                 6720             


Ser Leu  Gly Ile Thr Glu Ser  Ser Asn Met Thr Ile  Ile Thr Arg 
    6725                 6730                 6735             


Thr Gly  Pro Pro Leu Gly Ser  Thr Ser Gln Gly Thr  Phe Thr Leu 
    6740                 6745                 6750             


Asp Thr  Pro Thr Thr Ser Ser  Arg Ala Gly Thr His  Ser Met Ala 
    6755                 6760                 6765             


Thr Gln  Glu Phe Pro His Ser  Glu Met Thr Thr Val  Met Asn Lys 
    6770                 6775                 6780             


Asp Pro  Glu Ile Leu Ser Trp  Thr Ile Pro Pro Ser  Ile Glu Lys 
    6785                 6790                 6795             


Thr Ser  Phe Ser Ser Ser Leu  Met Pro Ser Pro Ala  Met Thr Ser 
    6800                 6805                 6810             


Pro Pro  Val Ser Ser Thr Leu  Pro Lys Thr Ile His  Thr Thr Pro 
    6815                 6820                 6825             


Ser Pro  Met Thr Ser Leu Leu  Thr Pro Ser Leu Val  Met Thr Thr 
    6830                 6835                 6840             


Asp Thr  Leu Gly Thr Ser Pro  Glu Pro Thr Thr Ser  Ser Pro Pro 
    6845                 6850                 6855             


Asn Leu  Ser Ser Thr Ser His  Glu Ile Leu Thr Thr  Asp Glu Asp 
    6860                 6865                 6870             


Thr Thr  Ala Ile Glu Ala Met  His Pro Ser Thr Ser  Thr Ala Ala 
    6875                 6880                 6885             


Thr Asn  Val Glu Thr Thr Ser  Ser Gly His Gly Ser  Gln Ser Ser 
    6890                 6895                 6900             


Val Leu  Ala Asp Ser Glu Lys  Thr Lys Ala Thr Ala  Pro Met Asp 
    6905                 6910                 6915             


Thr Thr  Ser Thr Met Gly His  Thr Thr Val Ser Thr  Ser Met Ser 
    6920                 6925                 6930             


Val Ser  Ser Glu Thr Thr Lys  Ile Lys Arg Glu Ser  Thr Tyr Ser 
    6935                 6940                 6945             


Leu Thr  Pro Gly Leu Arg Glu  Thr Ser Ile Ser Gln  Asn Ala Ser 
    6950                 6955                 6960             


Phe Ser  Thr Asp Thr Ser Ile  Val Leu Ser Glu Val  Pro Thr Gly 
    6965                 6970                 6975             


Thr Thr  Ala Glu Val Ser Arg  Thr Glu Val Thr Ser  Ser Gly Arg 
    6980                 6985                 6990             


Thr Ser  Ile Pro Gly Pro Ser  Gln Ser Thr Val Leu  Pro Glu Ile 
    6995                 7000                 7005             


Ser Thr  Arg Thr Met Thr Arg  Leu Phe Ala Ser Pro  Thr Met Thr 
    7010                 7015                 7020             


Glu Ser  Ala Glu Met Thr Ile  Pro Thr Gln Thr Gly  Pro Ser Gly 
    7025                 7030                 7035             


Ser Thr  Ser Gln Asp Thr Leu  Thr Leu Asp Thr Ser  Thr Thr Lys 
    7040                 7045                 7050             


Ser Gln  Ala Lys Thr His Ser  Thr Leu Thr Gln Arg  Phe Pro His 
    7055                 7060                 7065             


Ser Glu  Met Thr Thr Leu Met  Ser Arg Gly Pro Gly  Asp Met Ser 
    7070                 7075                 7080             


Trp Gln  Ser Ser Pro Ser Leu  Glu Asn Pro Ser Ser  Leu Pro Ser 
    7085                 7090                 7095             


Leu Leu  Ser Leu Pro Ala Thr  Thr Ser Pro Pro Pro  Ile Ser Ser 
    7100                 7105                 7110             


Thr Leu  Pro Val Thr Ile Ser  Ser Ser Pro Leu Pro  Val Thr Ser 
    7115                 7120                 7125             


Leu Leu  Thr Ser Ser Pro Val  Thr Thr Thr Asp Met  Leu His Thr 
    7130                 7135                 7140             


Ser Pro  Glu Leu Val Thr Ser  Ser Pro Pro Lys Leu  Ser His Thr 
    7145                 7150                 7155             


Ser Asp  Glu Arg Leu Thr Thr  Gly Lys Asp Thr Thr  Asn Thr Glu 
    7160                 7165                 7170             


Ala Val  His Pro Ser Thr Asn  Thr Ala Ala Ser Asn  Val Glu Ile 
    7175                 7180                 7185             


Pro Ser  Ser Gly His Glu Ser  Pro Ser Ser Ala Leu  Ala Asp Ser 
    7190                 7195                 7200             


Glu Thr  Ser Lys Ala Thr Ser  Pro Met Phe Ile Thr  Ser Thr Gln 
    7205                 7210                 7215             


Glu Asp  Thr Thr Val Ala Ile  Ser Thr Pro His Phe  Leu Glu Thr 
    7220                 7225                 7230             


Ser Arg  Ile Gln Lys Glu Ser  Ile Ser Ser Leu Ser  Pro Lys Leu 
    7235                 7240                 7245             


Arg Glu  Thr Gly Ser Ser Val  Glu Thr Ser Ser Ala  Ile Glu Thr 
    7250                 7255                 7260             


Ser Ala  Val Leu Ser Glu Val  Ser Ile Gly Ala Thr  Thr Glu Ile 
    7265                 7270                 7275             


Ser Arg  Thr Glu Val Thr Ser  Ser Ser Arg Thr Ser  Ile Ser Gly 
    7280                 7285                 7290             


Ser Ala  Glu Ser Thr Met Leu  Pro Glu Ile Ser Thr  Thr Arg Lys 
    7295                 7300                 7305             


Ile Ile  Lys Phe Pro Thr Ser  Pro Ile Leu Ala Glu  Ser Ser Glu 
    7310                 7315                 7320             


Met Thr  Ile Lys Thr Gln Thr  Ser Pro Pro Gly Ser  Thr Ser Glu 
    7325                 7330                 7335             


Ser Thr  Phe Thr Leu Asp Thr  Ser Thr Thr Pro Ser  Leu Val Ile 
    7340                 7345                 7350             


Thr His  Ser Thr Met Thr Gln  Arg Leu Pro His Ser  Glu Ile Thr 
    7355                 7360                 7365             


Thr Leu  Val Ser Arg Gly Ala  Gly Asp Val Pro Arg  Pro Ser Ser 
    7370                 7375                 7380             


Leu Pro  Val Glu Glu Thr Ser  Pro Pro Ser Ser Gln  Leu Ser Leu 
    7385                 7390                 7395             


Ser Ala  Met Ile Ser Pro Ser  Pro Val Ser Ser Thr  Leu Pro Ala 
    7400                 7405                 7410             


Ser Ser  His Ser Ser Ser Ala  Ser Val Thr Ser Leu  Leu Thr Pro 
    7415                 7420                 7425             


Gly Gln  Val Lys Thr Thr Glu  Val Leu Asp Ala Ser  Ala Glu Pro 
    7430                 7435                 7440             


Glu Thr  Ser Ser Pro Pro Ser  Leu Ser Ser Thr Ser  Val Glu Ile 
    7445                 7450                 7455             


Leu Ala  Thr Ser Glu Val Thr  Thr Asp Thr Glu Lys  Ile His Pro 
    7460                 7465                 7470             


Phe Ser  Asn Thr Ala Val Thr  Lys Val Gly Thr Ser  Ser Ser Gly 
    7475                 7480                 7485             


His Glu  Ser Pro Ser Ser Val  Leu Pro Asp Ser Glu  Thr Thr Lys 
    7490                 7495                 7500             


Ala Thr  Ser Ala Met Gly Thr  Ile Ser Ile Met Gly  Asp Thr Ser 
    7505                 7510                 7515             


Val Ser  Thr Leu Thr Pro Ala  Leu Ser Asn Thr Arg  Lys Ile Gln 
    7520                 7525                 7530             


Ser Glu  Pro Ala Ser Ser Leu  Thr Thr Arg Leu Arg  Glu Thr Ser 
    7535                 7540                 7545             


Thr Ser  Glu Glu Thr Ser Leu  Ala Thr Glu Ala Asn  Thr Val Leu 
    7550                 7555                 7560             


Ser Lys  Val Ser Thr Gly Ala  Thr Thr Glu Val Ser  Arg Thr Glu 
    7565                 7570                 7575             


Ala Ile  Ser Phe Ser Arg Thr  Ser Met Ser Gly Pro  Glu Gln Ser 
    7580                 7585                 7590             


Thr Met  Ser Gln Asp Ile Ser  Ile Gly Thr Ile Pro  Arg Ile Ser 
    7595                 7600                 7605             


Ala Ser  Ser Val Leu Thr Glu  Ser Ala Lys Met Thr  Ile Thr Thr 
    7610                 7615                 7620             


Gln Thr  Gly Pro Ser Glu Ser  Thr Leu Glu Ser Thr  Leu Asn Leu 
    7625                 7630                 7635             


Asn Thr  Ala Thr Thr Pro Ser  Trp Val Glu Thr His  Ser Ile Val 
    7640                 7645                 7650             


Ile Gln  Gly Phe Pro His Pro  Glu Met Thr Thr Ser  Met Gly Arg 
    7655                 7660                 7665             


Gly Pro  Gly Gly Val Ser Trp  Pro Ser Pro Pro Phe  Val Lys Glu 
    7670                 7675                 7680             


Thr Ser  Pro Pro Ser Ser Pro  Leu Ser Leu Pro Ala  Val Thr Ser 
    7685                 7690                 7695             


Pro His  Pro Val Ser Thr Thr  Phe Leu Ala His Ile  Pro Pro Ser 
    7700                 7705                 7710             


Pro Leu  Pro Val Thr Ser Leu  Leu Thr Ser Gly Pro  Ala Thr Thr 
    7715                 7720                 7725             


Thr Asp  Ile Leu Gly Thr Ser  Thr Glu Pro Gly Thr  Ser Ser Ser 
    7730                 7735                 7740             


Ser Ser  Leu Ser Thr Thr Ser  His Glu Arg Leu Thr  Thr Tyr Lys 
    7745                 7750                 7755             


Asp Thr  Ala His Thr Glu Ala  Val His Pro Ser Thr  Asn Thr Gly 
    7760                 7765                 7770             


Gly Thr  Asn Val Ala Thr Thr  Ser Ser Gly Tyr Lys  Ser Gln Ser 
    7775                 7780                 7785             


Ser Val  Leu Ala Asp Ser Ser  Pro Met Cys Thr Thr  Ser Thr Met 
    7790                 7795                 7800             


Gly Asp  Thr Ser Val Leu Thr  Ser Thr Pro Ala Phe  Leu Glu Thr 
    7805                 7810                 7815             


Arg Arg  Ile Gln Thr Glu Leu  Ala Ser Ser Leu Thr  Pro Gly Leu 
    7820                 7825                 7830             


Arg Glu  Ser Ser Gly Ser Glu  Gly Thr Ser Ser Gly  Thr Lys Met 
    7835                 7840                 7845             


Ser Thr  Val Leu Ser Lys Val  Pro Thr Gly Ala Thr  Thr Glu Ile 
    7850                 7855                 7860             


Ser Lys  Glu Asp Val Thr Ser  Ile Pro Gly Pro Ala  Gln Ser Thr 
    7865                 7870                 7875             


Ile Ser  Pro Asp Ile Ser Thr  Arg Thr Val Ser Trp  Phe Ser Thr 
    7880                 7885                 7890             


Ser Pro  Val Met Thr Glu Ser  Ala Glu Ile Thr Met  Asn Thr His 
    7895                 7900                 7905             


Thr Ser  Pro Leu Gly Ala Thr  Thr Gln Gly Thr Ser  Thr Leu Asp 
    7910                 7915                 7920             


Thr Ser  Ser Thr Thr Ser Leu  Thr Met Thr His Ser  Thr Ile Ser 
    7925                 7930                 7935             


Gln Gly  Phe Ser His Ser Gln  Met Ser Thr Leu Met  Arg Arg Gly 
    7940                 7945                 7950             


Pro Glu  Asp Val Ser Trp Met  Ser Pro Pro Leu Leu  Glu Lys Thr 
    7955                 7960                 7965             


Arg Pro  Ser Phe Ser Leu Met  Ser Ser Pro Ala Thr  Thr Ser Pro 
    7970                 7975                 7980             


Ser Pro  Val Ser Ser Thr Leu  Pro Glu Ser Ile Ser  Ser Ser Pro 
    7985                 7990                 7995             


Leu Pro  Val Thr Ser Leu Leu  Thr Ser Gly Leu Ala  Lys Thr Thr 
    8000                 8005                 8010             


Asp Met  Leu His Lys Ser Ser  Glu Pro Val Thr Asn  Ser Pro Ala 
    8015                 8020                 8025             


Asn Leu  Ser Ser Thr Ser Val  Glu Ile Leu Ala Thr  Ser Glu Val 
    8030                 8035                 8040             


Thr Thr  Asp Thr Glu Lys Thr  His Pro Ser Ser Asn  Arg Thr Val 
    8045                 8050                 8055             


Thr Asp  Val Gly Thr Ser Ser  Ser Gly His Glu Ser  Thr Ser Phe 
    8060                 8065                 8070             


Val Leu  Ala Asp Ser Gln Thr  Ser Lys Val Thr Ser  Pro Met Val 
    8075                 8080                 8085             


Ile Thr  Ser Thr Met Glu Asp  Thr Ser Val Ser Thr  Ser Thr Pro 
    8090                 8095                 8100             


Gly Phe  Phe Glu Thr Ser Arg  Ile Gln Thr Glu Pro  Thr Ser Ser 
    8105                 8110                 8115             


Leu Thr  Leu Gly Leu Arg Lys  Thr Ser Ser Ser Glu  Gly Thr Ser 
    8120                 8125                 8130             


Leu Ala  Thr Glu Met Ser Thr  Val Leu Ser Gly Val  Pro Thr Gly 
    8135                 8140                 8145             


Ala Thr  Ala Glu Val Ser Arg  Thr Glu Val Thr Ser  Ser Ser Arg 
    8150                 8155                 8160             


Thr Ser  Ile Ser Gly Phe Ala  Gln Leu Thr Val Ser  Pro Glu Thr 
    8165                 8170                 8175             


Ser Thr  Glu Thr Ile Thr Arg  Leu Pro Thr Ser Ser  Ile Met Thr 
    8180                 8185                 8190             


Glu Ser  Ala Glu Met Met Ile  Lys Thr Gln Thr Asp  Pro Pro Gly 
    8195                 8200                 8205             


Ser Thr  Pro Glu Ser Thr His  Thr Val Asp Ile Ser  Thr Thr Pro 
    8210                 8215                 8220             


Asn Trp  Val Glu Thr His Ser  Thr Val Thr Gln Arg  Phe Ser His 
    8225                 8230                 8235             


Ser Glu  Met Thr Thr Leu Val  Ser Arg Ser Pro Gly  Asp Met Leu 
    8240                 8245                 8250             


Trp Pro  Ser Gln Ser Ser Val  Glu Glu Thr Ser Ser  Ala Ser Ser 
    8255                 8260                 8265             


Leu Leu  Ser Leu Pro Ala Thr  Thr Ser Pro Ser Pro  Val Ser Ser 
    8270                 8275                 8280             


Thr Leu  Val Glu Asp Phe Pro  Ser Ala Ser Leu Pro  Val Thr Ser 
    8285                 8290                 8295             


Leu Leu  Asn Pro Gly Leu Val  Ile Thr Thr Asp Arg  Met Gly Ile 
    8300                 8305                 8310             


Ser Arg  Glu Pro Gly Thr Ser  Ser Thr Ser Asn Leu  Ser Ser Thr 
    8315                 8320                 8325             


Ser His  Glu Arg Leu Thr Thr  Leu Glu Asp Thr Val  Asp Thr Glu 
    8330                 8335                 8340             


Asp Met  Gln Pro Ser Thr His  Thr Ala Val Thr Asn  Val Arg Thr 
    8345                 8350                 8355             


Ser Ile  Ser Gly His Glu Ser  Gln Ser Ser Val Leu  Ser Asp Ser 
    8360                 8365                 8370             


Glu Thr  Pro Lys Ala Thr Ser  Pro Met Gly Thr Thr  Tyr Thr Met 
    8375                 8380                 8385             


Gly Glu  Thr Ser Val Ser Ile  Ser Thr Ser Asp Phe  Phe Glu Thr 
    8390                 8395                 8400             


Ser Arg  Ile Gln Ile Glu Pro  Thr Ser Ser Leu Thr  Ser Gly Leu 
    8405                 8410                 8415             


Arg Glu  Thr Ser Ser Ser Glu  Arg Ile Ser Ser Ala  Thr Glu Gly 
    8420                 8425                 8430             


Ser Thr  Val Leu Ser Glu Val  Pro Ser Gly Ala Thr  Thr Glu Val 
    8435                 8440                 8445             


Ser Arg  Thr Glu Val Ile Ser  Ser Arg Gly Thr Ser  Met Ser Gly 
    8450                 8455                 8460             


Pro Asp  Gln Phe Thr Ile Ser  Pro Asp Ile Ser Thr  Glu Ala Ile 
    8465                 8470                 8475             


Thr Arg  Leu Ser Thr Ser Pro  Ile Met Thr Glu Ser  Ala Glu Ser 
    8480                 8485                 8490             


Ala Ile  Thr Ile Glu Thr Gly  Ser Pro Gly Ala Thr  Ser Glu Gly 
    8495                 8500                 8505             


Thr Leu  Thr Leu Asp Thr Ser  Thr Thr Thr Phe Trp  Ser Gly Thr 
    8510                 8515                 8520             


His Ser  Thr Ala Ser Pro Gly  Phe Ser His Ser Glu  Met Thr Thr 
    8525                 8530                 8535             


Leu Met  Ser Arg Thr Pro Gly  Asp Val Pro Trp Pro  Ser Leu Pro 
    8540                 8545                 8550             


Ser Val  Glu Glu Ala Ser Ser  Val Ser Ser Ser Leu  Ser Ser Pro 
    8555                 8560                 8565             


Ala Met  Thr Ser Thr Ser Phe  Phe Ser Thr Leu Pro  Glu Ser Ile 
    8570                 8575                 8580             


Ser Ser  Ser Pro His Pro Val  Thr Ala Leu Leu Thr  Leu Gly Pro 
    8585                 8590                 8595             


Val Lys  Thr Thr Asp Met Leu  Arg Thr Ser Ser Glu  Pro Glu Thr 
    8600                 8605                 8610             


Ser Ser  Pro Pro Asn Leu Ser  Ser Thr Ser Ala Glu  Ile Leu Ala 
    8615                 8620                 8625             


Thr Ser  Glu Val Thr Lys Asp  Arg Glu Lys Ile His  Pro Ser Ser 
    8630                 8635                 8640             


Asn Thr  Pro Val Val Asn Val  Gly Thr Val Ile Tyr  Lys His Leu 
    8645                 8650                 8655             


Ser Pro  Ser Ser Val Leu Ala  Asp Leu Val Thr Thr  Lys Pro Thr 
    8660                 8665                 8670             


Ser Pro  Met Ala Thr Thr Ser  Thr Leu Gly Asn Thr  Ser Val Ser 
    8675                 8680                 8685             


Thr Ser  Thr Pro Ala Phe Pro  Glu Thr Met Met Thr  Gln Pro Thr 
    8690                 8695                 8700             


Ser Ser  Leu Thr Ser Gly Leu  Arg Glu Ile Ser Thr  Ser Gln Glu 
    8705                 8710                 8715             


Thr Ser  Ser Ala Thr Glu Arg  Ser Ala Ser Leu Ser  Gly Met Pro 
    8720                 8725                 8730             


Thr Gly  Ala Thr Thr Lys Val  Ser Arg Thr Glu Ala  Leu Ser Leu 
    8735                 8740                 8745             


Gly Arg  Thr Ser Thr Pro Gly  Pro Ala Gln Ser Thr  Ile Ser Pro 
    8750                 8755                 8760             


Glu Ile  Ser Thr Glu Thr Ile  Thr Arg Ile Ser Thr  Pro Leu Thr 
    8765                 8770                 8775             


Thr Thr  Gly Ser Ala Glu Met  Thr Ile Thr Pro Lys  Thr Gly His 
    8780                 8785                 8790             


Ser Gly  Ala Ser Ser Gln Gly  Thr Phe Thr Leu Asp  Thr Ser Ser 
    8795                 8800                 8805             


Arg Ala  Ser Trp Pro Gly Thr  His Ser Ala Ala Thr  His Arg Ser 
    8810                 8815                 8820             


Pro His  Ser Gly Met Thr Thr  Pro Met Ser Arg Gly  Pro Glu Asp 
    8825                 8830                 8835             


Val Ser  Trp Pro Ser Arg Pro  Ser Val Glu Lys Thr  Ser Pro Pro 
    8840                 8845                 8850             


Ser Ser  Leu Val Ser Leu Ser  Ala Val Thr Ser Pro  Ser Pro Leu 
    8855                 8860                 8865             


Tyr Ser  Thr Pro Ser Glu Ser  Ser His Ser Ser Pro  Leu Arg Val 
    8870                 8875                 8880             


Thr Ser  Leu Phe Thr Pro Val  Met Met Lys Thr Thr  Asp Met Leu 
    8885                 8890                 8895             


Asp Thr  Ser Leu Glu Pro Val  Thr Thr Ser Pro Pro  Ser Met Asn 
    8900                 8905                 8910             


Ile Thr  Ser Asp Glu Ser Leu  Ala Thr Ser Lys Ala  Thr Met Glu 
    8915                 8920                 8925             


Thr Glu  Ala Ile Gln Leu Ser  Glu Asn Thr Ala Val  Thr Gln Met 
    8930                 8935                 8940             


Gly Thr  Ile Ser Ala Arg Gln  Glu Phe Tyr Ser Ser  Tyr Pro Gly 
    8945                 8950                 8955             


Leu Pro  Glu Pro Ser Lys Val  Thr Ser Pro Val Val  Thr Ser Ser 
    8960                 8965                 8970             


Thr Ile  Lys Asp Ile Val Ser  Thr Thr Ile Pro Ala  Ser Ser Glu 
    8975                 8980                 8985             


Ile Thr  Arg Ile Glu Met Glu  Ser Thr Ser Thr Leu  Thr Pro Thr 
    8990                 8995                 9000             


Pro Arg  Glu Thr Ser Thr Ser  Gln Glu Ile His Ser  Ala Thr Lys 
    9005                 9010                 9015             


Pro Ser  Thr Val Pro Tyr Lys  Ala Leu Thr Ser Ala  Thr Ile Glu 
    9020                 9025                 9030             


Asp Ser  Met Thr Gln Val Met  Ser Ser Ser Arg Gly  Pro Ser Pro 
    9035                 9040                 9045             


Asp Gln  Ser Thr Met Ser Gln  Asp Ile Ser Thr Glu  Val Ile Thr 
    9050                 9055                 9060             


Arg Leu  Ser Thr Ser Pro Ile  Lys Thr Glu Ser Thr  Glu Met Thr 
    9065                 9070                 9075             


Ile Thr  Thr Gln Thr Gly Ser  Pro Gly Ala Thr Ser  Arg Gly Thr 
    9080                 9085                 9090             


Leu Thr  Leu Asp Thr Ser Thr  Thr Phe Met Ser Gly  Thr His Ser 
    9095                 9100                 9105             


Thr Ala  Ser Gln Gly Phe Ser  His Ser Gln Met Thr  Ala Leu Met 
    9110                 9115                 9120             


Ser Arg  Thr Pro Gly Asp Val  Pro Trp Leu Ser His  Pro Ser Val 
    9125                 9130                 9135             


Glu Glu  Ala Ser Ser Ala Ser  Phe Ser Leu Ser Ser  Pro Val Met 
    9140                 9145                 9150             


Thr Ser  Ser Ser Pro Val Ser  Ser Thr Leu Pro Asp  Ser Ile His 
    9155                 9160                 9165             


Ser Ser  Ser Leu Pro Val Thr  Ser Leu Leu Thr Ser  Gly Leu Val 
    9170                 9175                 9180             


Lys Thr  Thr Glu Leu Leu Gly  Thr Ser Ser Glu Pro  Glu Thr Ser 
    9185                 9190                 9195             


Ser Pro  Pro Asn Leu Ser Ser  Thr Ser Ala Glu Ile  Leu Ala Ile 
    9200                 9205                 9210             


Thr Glu  Val Thr Thr Asp Thr  Glu Lys Leu Glu Met  Thr Asn Val 
    9215                 9220                 9225             


Val Thr  Ser Gly Tyr Thr His  Glu Ser Pro Ser Ser  Val Leu Ala 
    9230                 9235                 9240             


Asp Ser  Val Thr Thr Lys Ala  Thr Ser Ser Met Gly  Ile Thr Tyr 
    9245                 9250                 9255             


Pro Thr  Gly Asp Thr Asn Val  Leu Thr Ser Thr Pro  Ala Phe Ser 
    9260                 9265                 9270             


Asp Thr  Ser Arg Ile Gln Thr  Lys Ser Lys Leu Ser  Leu Thr Pro 
    9275                 9280                 9285             


Gly Leu  Met Glu Thr Ser Ile  Ser Glu Glu Thr Ser  Ser Ala Thr 
    9290                 9295                 9300             


Glu Lys  Ser Thr Val Leu Ser  Ser Val Pro Thr Gly  Ala Thr Thr 
    9305                 9310                 9315             


Glu Val  Ser Arg Thr Glu Ala  Ile Ser Ser Ser Arg  Thr Ser Ile 
    9320                 9325                 9330             


Pro Gly  Pro Ala Gln Ser Thr  Met Ser Ser Asp Thr  Ser Met Glu 
    9335                 9340                 9345             


Thr Ile  Thr Arg Ile Ser Thr  Pro Leu Thr Arg Lys  Glu Ser Thr 
    9350                 9355                 9360             


Asp Met  Ala Ile Thr Pro Lys  Thr Gly Pro Ser Gly  Ala Thr Ser 
    9365                 9370                 9375             


Gln Gly  Thr Phe Thr Leu Asp  Ser Ser Ser Thr Ala  Ser Trp Pro 
    9380                 9385                 9390             


Gly Thr  His Ser Ala Thr Thr  Gln Arg Phe Pro Gln  Ser Val Val 
    9395                 9400                 9405             


Thr Thr  Pro Met Ser Arg Gly  Pro Glu Asp Val Ser  Trp Pro Ser 
    9410                 9415                 9420             


Pro Leu  Ser Val Glu Lys Asn  Ser Pro Pro Ser Ser  Leu Val Ser 
    9425                 9430                 9435             


Ser Ser  Ser Val Thr Ser Pro  Ser Pro Leu Tyr Ser  Thr Pro Ser 
    9440                 9445                 9450             


Gly Ser  Ser His Ser Ser Pro  Val Pro Val Thr Ser  Leu Phe Thr 
    9455                 9460                 9465             


Ser Ile  Met Met Lys Ala Thr  Asp Met Leu Asp Ala  Ser Leu Glu 
    9470                 9475                 9480             


Pro Glu  Thr Thr Ser Ala Pro  Asn Met Asn Ile Thr  Ser Asp Glu 
    9485                 9490                 9495             


Ser Leu  Ala Ala Ser Lys Ala  Thr Thr Glu Thr Glu  Ala Ile His 
    9500                 9505                 9510             


Val Phe  Glu Asn Thr Ala Ala  Ser His Val Glu Thr  Thr Ser Ala 
    9515                 9520                 9525             


Thr Glu  Glu Leu Tyr Ser Ser  Ser Pro Gly Phe Ser  Glu Pro Thr 
    9530                 9535                 9540             


Lys Val  Ile Ser Pro Val Val  Thr Ser Ser Ser Ile  Arg Asp Asn 
    9545                 9550                 9555             


Met Val  Ser Thr Thr Met Pro  Gly Ser Ser Gly Ile  Thr Arg Ile 
    9560                 9565                 9570             


Glu Ile  Glu Ser Met Ser Ser  Leu Thr Pro Gly Leu  Arg Glu Thr 
    9575                 9580                 9585             


Arg Thr  Ser Gln Asp Ile Thr  Ser Ser Thr Glu Thr  Ser Thr Val 
    9590                 9595                 9600             


Leu Tyr  Lys Met Pro Ser Gly  Ala Thr Pro Glu Val  Ser Arg Thr 
    9605                 9610                 9615             


Glu Val  Met Pro Ser Ser Arg  Thr Ser Ile Pro Gly  Pro Ala Gln 
    9620                 9625                 9630             


Ser Thr  Met Ser Leu Asp Ile  Ser Asp Glu Val Val  Thr Arg Leu 
    9635                 9640                 9645             


Ser Thr  Ser Pro Ile Met Thr  Glu Ser Ala Glu Ile  Thr Ile Thr 
    9650                 9655                 9660             


Thr Gln  Thr Gly Tyr Ser Leu  Ala Thr Ser Gln Val  Thr Leu Pro 
    9665                 9670                 9675             


Leu Gly  Thr Ser Met Thr Phe  Leu Ser Gly Thr His  Ser Thr Met 
    9680                 9685                 9690             


Ser Gln  Gly Leu Ser His Ser  Glu Met Thr Asn Leu  Met Ser Arg 
    9695                 9700                 9705             


Gly Pro  Glu Ser Leu Ser Trp  Thr Ser Pro Arg Phe  Val Glu Thr 
    9710                 9715                 9720             


Thr Arg  Ser Ser Ser Ser Leu  Thr Ser Leu Pro Leu  Thr Thr Ser 
    9725                 9730                 9735             


Leu Ser  Pro Val Ser Ser Thr  Leu Leu Asp Ser Ser  Pro Ser Ser 
    9740                 9745                 9750             


Pro Leu  Pro Val Thr Ser Leu  Ile Leu Pro Gly Leu  Val Lys Thr 
    9755                 9760                 9765             


Thr Glu  Val Leu Asp Thr Ser  Ser Glu Pro Lys Thr  Ser Ser Ser 
    9770                 9775                 9780             


Pro Asn  Leu Ser Ser Thr Ser  Val Glu Ile Pro Ala  Thr Ser Glu 
    9785                 9790                 9795             


Ile Met  Thr Asp Thr Glu Lys  Ile His Pro Ser Ser  Asn Thr Ala 
    9800                 9805                 9810             


Val Ala  Lys Val Arg Thr Ser  Ser Ser Val His Glu  Ser His Ser 
    9815                 9820                 9825             


Ser Val  Leu Ala Asp Ser Glu  Thr Thr Ile Thr Ile  Pro Ser Met 
    9830                 9835                 9840             


Gly Ile  Thr Ser Ala Val Asp  Asp Thr Thr Val Phe  Thr Ser Asn 
    9845                 9850                 9855             


Pro Ala  Phe Ser Glu Thr Arg  Arg Ile Pro Thr Glu  Pro Thr Phe 
    9860                 9865                 9870             


Ser Leu  Thr Pro Gly Phe Arg  Glu Thr Ser Thr Ser  Glu Glu Thr 
    9875                 9880                 9885             


Thr Ser  Ile Thr Glu Thr Ser  Ala Val Leu Tyr Gly  Val Pro Thr 
    9890                 9895                 9900             


Ser Ala  Thr Thr Glu Val Ser  Met Thr Glu Ile Met  Ser Ser Asn 
    9905                 9910                 9915             


Arg Ile  His Ile Pro Asp Ser  Asp Gln Ser Thr Met  Ser Pro Asp 
    9920                 9925                 9930             


Ile Ile  Thr Glu Val Ile Thr  Arg Leu Ser Ser Ser  Ser Met Met 
    9935                 9940                 9945             


Ser Glu  Ser Thr Gln Met Thr  Ile Thr Thr Gln Lys  Ser Ser Pro 
    9950                 9955                 9960             


Gly Ala  Thr Ala Gln Ser Thr  Leu Thr Leu Ala Thr  Thr Thr Ala 
    9965                 9970                 9975             


Pro Leu  Ala Arg Thr His Ser  Thr Val Pro Pro Arg  Phe Leu His 
    9980                 9985                 9990             


Ser Glu  Met Thr Thr Leu Met   Ser Arg Ser Pro Glu   Asn Pro Ser 
    9995                 10000                 10005             


Trp Lys   Ser Ser Leu Phe Val   Glu Lys Thr Ser Ser   Ser Ser Ser 
    10010                 10015                 10020             


Leu Leu   Ser Leu Pro Val Thr   Thr Ser Pro Ser Val   Ser Ser Thr 
    10025                 10030                 10035             


Leu Pro   Gln Ser Ile Pro Ser   Ser Ser Phe Ser Val   Thr Ser Leu 
    10040                 10045                 10050             


Leu Thr   Pro Gly Met Val Lys   Thr Thr Asp Thr Ser   Thr Glu Pro 
    10055                 10060                 10065             


Gly Thr   Ser Leu Ser Pro Asn   Leu Ser Gly Thr Ser   Val Glu Ile 
    10070                 10075                 10080             


Leu Ala   Ala Ser Glu Val Thr   Thr Asp Thr Glu Lys   Ile His Pro 
    10085                 10090                 10095             


Ser Ser   Ser Met Ala Val Thr   Asn Val Gly Thr Thr   Ser Ser Gly 
    10100                 10105                 10110             


His Glu   Leu Tyr Ser Ser Val   Ser Ile His Ser Glu   Pro Ser Lys 
    10115                 10120                 10125             


Ala Thr   Tyr Pro Val Gly Thr   Pro Ser Ser Met Ala   Glu Thr Ser 
    10130                 10135                 10140             


Ile Ser   Thr Ser Met Pro Ala   Asn Phe Glu Thr Thr   Gly Phe Glu 
    10145                 10150                 10155             


Ala Glu   Pro Phe Ser His Leu   Thr Ser Gly Phe Arg   Lys Thr Asn 
    10160                 10165                 10170             


Met Ser   Leu Asp Thr Ser Ser   Val Thr Pro Thr Asn   Thr Pro Ser 
    10175                 10180                 10185             


Ser Pro   Gly Ser Thr His Leu   Leu Gln Ser Ser Lys   Thr Asp Phe 
    10190                 10195                 10200             


Thr Ser   Ser Ala Lys Thr Ser   Ser Pro Asp Trp Pro   Pro Ala Ser 
    10205                 10210                 10215             


Gln Tyr   Thr Glu Ile Pro Val   Asp Ile Ile Thr Pro   Phe Asn Ala 
    10220                 10225                 10230             


Ser Pro   Ser Ile Thr Glu Ser   Thr Gly Ile Thr Ser   Phe Pro Glu 
    10235                 10240                 10245             


Ser Arg   Phe Thr Met Ser Val   Thr Glu Ser Thr His   His Leu Ser 
    10250                 10255                 10260             


Thr Asp   Leu Leu Pro Ser Ala   Glu Thr Ile Ser Thr   Gly Thr Val 
    10265                 10270                 10275             


Met Pro   Ser Leu Ser Glu Ala   Met Thr Ser Phe Ala   Thr Thr Gly 
    10280                 10285                 10290             


Val Pro   Arg Ala Ile Ser Gly   Ser Gly Ser Pro Phe   Ser Arg Thr 
    10295                 10300                 10305             


Glu Ser   Gly Pro Gly Asp Ala   Thr Leu Ser Thr Ile   Ala Glu Ser 
    10310                 10315                 10320             


Leu Pro   Ser Ser Thr Pro Val   Pro Phe Ser Ser Ser   Thr Phe Thr 
    10325                 10330                 10335             


Thr Thr   Asp Ser Ser Thr Ile   Pro Ala Leu His Glu   Ile Thr Ser 
    10340                 10345                 10350             


Ser Ser   Ala Thr Pro Tyr Arg   Val Asp Thr Ser Leu   Gly Thr Glu 
    10355                 10360                 10365             


Ser Ser   Thr Thr Glu Gly Arg   Leu Val Met Val Ser   Thr Leu Asp 
    10370                 10375                 10380             


Thr Ser   Ser Gln Pro Gly Arg   Thr Ser Ser Ser Pro   Ile Leu Asp 
    10385                 10390                 10395             


Thr Arg   Met Thr Glu Ser Val   Glu Leu Gly Thr Val   Thr Ser Ala 
    10400                 10405                 10410             


Tyr Gln   Val Pro Ser Leu Ser   Thr Arg Leu Thr Arg   Thr Asp Gly 
    10415                 10420                 10425             


Ile Met   Glu His Ile Thr Lys   Ile Pro Asn Glu Ala   Ala His Arg 
    10430                 10435                 10440             


Gly Thr   Ile Arg Pro Val Lys   Gly Pro Gln Thr Ser   Thr Ser Pro 
    10445                 10450                 10455             


Ala Ser   Pro Lys Gly Leu His   Thr Gly Gly Thr Lys   Arg Met Glu 
    10460                 10465                 10470             


Thr Thr   Thr Thr Ala Leu Lys   Thr Thr Thr Thr Ala   Leu Lys Thr 
    10475                 10480                 10485             


Thr Ser   Arg Ala Thr Leu Thr   Thr Ser Val Tyr Thr   Pro Thr Leu 
    10490                 10495                 10500             


Gly Thr   Leu Thr Pro Leu Asn   Ala Ser Met Gln Met   Ala Ser Thr 
    10505                 10510                 10515             


Ile Pro   Thr Glu Met Met Ile   Thr Thr Pro Tyr Val   Phe Pro Asp 
    10520                 10525                 10530             


Val Pro   Glu Thr Thr Ser Ser   Leu Ala Thr Ser Leu   Gly Ala Glu 
    10535                 10540                 10545             


Thr Ser   Thr Ala Leu Pro Arg   Thr Thr Pro Ser Val   Phe Asn Arg 
    10550                 10555                 10560             


Glu Ser   Glu Thr Thr Ala Ser   Leu Val Ser Arg Ser   Gly Ala Glu 
    10565                 10570                 10575             


Arg Ser   Pro Val Ile Gln Thr   Leu Asp Val Ser Ser   Ser Glu Pro 
    10580                 10585                 10590             


Asp Thr   Thr Ala Ser Trp Val   Ile His Pro Ala Glu   Thr Ile Pro 
    10595                 10600                 10605             


Thr Val   Ser Lys Thr Thr Pro   Asn Phe Phe His Ser   Glu Leu Asp 
    10610                 10615                 10620             


Thr Val   Ser Ser Thr Ala Thr   Ser His Gly Ala Asp   Val Ser Ser 
    10625                 10630                 10635             


Ala Ile   Pro Thr Asn Ile Ser   Pro Ser Glu Leu Asp   Ala Leu Thr 
    10640                 10645                 10650             


Pro Leu   Val Thr Ile Ser Gly   Thr Asp Thr Ser Thr   Thr Phe Pro 
    10655                 10660                 10665             


Thr Leu   Thr Lys Ser Pro His   Glu Thr Glu Thr Arg   Thr Thr Trp 
    10670                 10675                 10680             


Leu Thr   His Pro Ala Glu Thr   Ser Ser Thr Ile Pro   Arg Thr Ile 
    10685                 10690                 10695             


Pro Asn   Phe Ser His His Glu   Ser Asp Ala Thr Pro   Ser Ile Ala 
    10700                 10705                 10710             


Thr Ser   Pro Gly Ala Glu Thr   Ser Ser Ala Ile Pro   Ile Met Thr 
    10715                 10720                 10725             


Val Ser   Pro Gly Ala Glu Asp   Leu Val Thr Ser Gln   Val Thr Ser 
    10730                 10735                 10740             


Ser Gly   Thr Asp Arg Asn Met   Thr Ile Pro Thr Leu   Thr Leu Ser 
    10745                 10750                 10755             


Pro Gly   Glu Pro Lys Thr Ile   Ala Ser Leu Val Thr   His Pro Glu 
    10760                 10765                 10770             


Ala Gln   Thr Ser Ser Ala Ile   Pro Thr Ser Thr Ile   Ser Pro Ala 
    10775                 10780                 10785             


Val Ser   Arg Leu Val Thr Ser   Met Val Thr Ser Leu   Ala Ala Lys 
    10790                 10795                 10800             


Thr Ser   Thr Thr Asn Arg Ala   Leu Thr Asn Ser Pro   Gly Glu Pro 
    10805                 10810                 10815             


Ala Thr   Thr Val Ser Leu Val   Thr His Pro Ala Gln   Thr Ser Pro 
    10820                 10825                 10830             


Thr Val   Pro Trp Thr Thr Ser   Ile Phe Phe His Ser   Lys Ser Asp 
    10835                 10840                 10845             


Thr Thr   Pro Ser Met Thr Thr   Ser His Gly Ala Glu   Ser Ser Ser 
    10850                 10855                 10860             


Ala Val   Pro Thr Pro Thr Val   Ser Thr Glu Val Pro   Gly Val Val 
    10865                 10870                 10875             


Thr Pro   Leu Val Thr Ser Ser   Arg Ala Val Ile Ser   Thr Thr Ile 
    10880                 10885                 10890             


Pro Ile   Leu Thr Leu Ser Pro   Gly Glu Pro Glu Thr   Thr Pro Ser 
    10895                 10900                 10905             


Met Ala   Thr Ser His Gly Glu   Glu Ala Ser Ser Ala   Ile Pro Thr 
    10910                 10915                 10920             


Pro Thr   Val Ser Pro Gly Val   Pro Gly Val Val Thr   Ser Leu Val 
    10925                 10930                 10935             


Thr Ser   Ser Arg Ala Val Thr   Ser Thr Thr Ile Pro   Ile Leu Thr 
    10940                 10945                 10950             


Phe Ser   Leu Gly Glu Pro Glu   Thr Thr Pro Ser Met   Ala Thr Ser 
    10955                 10960                 10965             


His Gly   Thr Glu Ala Gly Ser   Ala Val Pro Thr Val   Leu Pro Glu 
    10970                 10975                 10980             


Val Pro   Gly Met Val Thr Ser   Leu Val Ala Ser Ser   Arg Ala Val 
    10985                 10990                 10995             


Thr Ser   Thr Thr Leu Pro Thr   Leu Thr Leu Ser Pro   Gly Glu Pro 
    11000                 11005                 11010             


Glu Thr   Thr Pro Ser Met Ala   Thr Ser His Gly Ala   Glu Ala Ser 
    11015                 11020                 11025             


Ser Thr   Val Pro Thr Val Ser   Pro Glu Val Pro Gly   Val Val Thr 
    11030                 11035                 11040             


Ser Leu   Val Thr Ser Ser Ser   Gly Val Asn Ser Thr   Ser Ile Pro 
    11045                 11050                 11055             


Thr Leu   Ile Leu Ser Pro Gly   Glu Leu Glu Thr Thr   Pro Ser Met 
    11060                 11065                 11070             


Ala Thr   Ser His Gly Ala Glu   Ala Ser Ser Ala Val   Pro Thr Pro 
    11075                 11080                 11085             


Thr Val   Ser Pro Gly Val Ser   Gly Val Val Thr Pro   Leu Val Thr 
    11090                 11095                 11100             


Ser Ser   Arg Ala Val Thr Ser   Thr Thr Ile Pro Ile   Leu Thr Leu 
    11105                 11110                 11115             


Ser Ser   Ser Glu Pro Glu Thr   Thr Pro Ser Met Ala   Thr Ser His 
    11120                 11125                 11130             


Gly Val   Glu Ala Ser Ser Ala   Val Leu Thr Val Ser   Pro Glu Val 
    11135                 11140                 11145             


Pro Gly   Met Val Thr Ser Leu   Val Thr Ser Ser Arg   Ala Val Thr 
    11150                 11155                 11160             


Ser Thr   Thr Ile Pro Thr Leu   Thr Ile Ser Ser Asp   Glu Pro Glu 
    11165                 11170                 11175             


Thr Thr   Thr Ser Leu Val Thr   His Ser Glu Ala Lys   Met Ile Ser 
    11180                 11185                 11190             


Ala Ile   Pro Thr Leu Ala Val   Ser Pro Thr Val Gln   Gly Leu Val 
    11195                 11200                 11205             


Thr Ser   Leu Val Thr Ser Ser   Gly Ser Glu Thr Ser   Ala Phe Ser 
    11210                 11215                 11220             


Asn Leu   Thr Val Ala Ser Ser   Gln Pro Glu Thr Ile   Asp Ser Trp 
    11225                 11230                 11235             


Val Ala   His Pro Gly Thr Glu   Ala Ser Ser Val Val   Pro Thr Leu 
    11240                 11245                 11250             


Thr Val   Ser Thr Gly Glu Pro   Phe Thr Asn Ile Ser   Leu Val Thr 
    11255                 11260                 11265             


His Pro   Ala Glu Ser Ser Ser   Thr Leu Pro Arg Thr   Thr Ser Arg 
    11270                 11275                 11280             


Phe Ser   His Ser Glu Leu Asp   Thr Met Pro Ser Thr   Val Thr Ser 
    11285                 11290                 11295             


Pro Glu   Ala Glu Ser Ser Ser   Ala Ile Ser Thr Thr   Ile Ser Pro 
    11300                 11305                 11310             


Gly Ile   Pro Gly Val Leu Thr   Ser Leu Val Thr Ser   Ser Gly Arg 
    11315                 11320                 11325             


Asp Ile   Ser Ala Thr Phe Pro   Thr Val Pro Glu Ser   Pro His Glu 
    11330                 11335                 11340             


Ser Glu   Ala Thr Ala Ser Trp   Val Thr His Pro Ala   Val Thr Ser 
    11345                 11350                 11355             


Thr Thr   Val Pro Arg Thr Thr   Pro Asn Tyr Ser His   Ser Glu Pro 
    11360                 11365                 11370             


Asp Thr   Thr Pro Ser Ile Ala   Thr Ser Pro Gly Ala   Glu Ala Thr 
    11375                 11380                 11385             


Ser Asp   Phe Pro Thr Ile Thr   Val Ser Pro Asp Val   Pro Asp Met 
    11390                 11395                 11400             


Val Thr   Ser Gln Val Thr Ser   Ser Gly Thr Asp Thr   Ser Ile Thr 
    11405                 11410                 11415             


Ile Pro   Thr Leu Thr Leu Ser   Ser Gly Glu Pro Glu   Thr Thr Thr 
    11420                 11425                 11430             


Ser Phe   Ile Thr Tyr Ser Glu   Thr His Thr Ser Ser   Ala Ile Pro 
    11435                 11440                 11445             


Thr Leu   Pro Val Ser Pro Gly   Ala Ser Lys Met Leu   Thr Ser Leu 
    11450                 11455                 11460             


Val Ile   Ser Ser Gly Thr Asp   Ser Thr Thr Thr Phe   Pro Thr Leu 
    11465                 11470                 11475             


Thr Glu   Thr Pro Tyr Glu Pro   Glu Thr Thr Ala Ile   Gln Leu Ile 
    11480                 11485                 11490             


His Pro   Ala Glu Thr Asn Thr   Met Val Pro Arg Thr   Thr Pro Lys 
    11495                 11500                 11505             


Phe Ser   His Ser Lys Ser Asp   Thr Thr Leu Pro Val   Ala Ile Thr 
    11510                 11515                 11520             


Ser Pro   Gly Pro Glu Ala Ser   Ser Ala Val Ser Thr   Thr Thr Ile 
    11525                 11530                 11535             


Ser Pro   Asp Met Ser Asp Leu   Val Thr Ser Leu Val   Pro Ser Ser 
    11540                 11545                 11550             


Gly Thr   Asp Thr Ser Thr Thr   Phe Pro Thr Leu Ser   Glu Thr Pro 
    11555                 11560                 11565             


Tyr Glu   Pro Glu Thr Thr Ala   Thr Trp Leu Thr His   Pro Ala Glu 
    11570                 11575                 11580             


Thr Ser   Thr Thr Val Ser Gly   Thr Ile Pro Asn Phe   Ser His Arg 
    11585                 11590                 11595             


Gly Ser   Asp Thr Ala Pro Ser   Met Val Thr Ser Pro   Gly Val Asp 
    11600                 11605                 11610             


Thr Arg   Ser Gly Val Pro Thr   Thr Thr Ile Pro Pro   Ser Ile Pro 
    11615                 11620                 11625             


Gly Val   Val Thr Ser Gln Val   Thr Ser Ser Ala Thr   Asp Thr Ser 
    11630                 11635                 11640             


Thr Ala   Ile Pro Thr Leu Thr   Pro Ser Pro Gly Glu   Pro Glu Thr 
    11645                 11650                 11655             


Thr Ala   Ser Ser Ala Thr His   Pro Gly Thr Gln Thr   Gly Phe Thr 
    11660                 11665                 11670             


Val Pro   Ile Arg Thr Val Pro   Ser Ser Glu Pro Asp   Thr Met Ala 
    11675                 11680                 11685             


Ser Trp   Val Thr His Pro Pro   Gln Thr Ser Thr Pro   Val Ser Arg 
    11690                 11695                 11700             


Thr Thr   Ser Ser Phe Ser His   Ser Ser Pro Asp Ala   Thr Pro Val 
    11705                 11710                 11715             


Met Ala   Thr Ser Pro Arg Thr   Glu Ala Ser Ser Ala   Val Leu Thr 
    11720                 11725                 11730             


Thr Ile   Ser Pro Gly Ala Pro   Glu Met Val Thr Ser   Gln Ile Thr 
    11735                 11740                 11745             


Ser Ser   Gly Ala Ala Thr Ser   Thr Thr Val Pro Thr   Leu Thr His 
    11750                 11755                 11760             


Ser Pro   Gly Met Pro Glu Thr   Thr Ala Leu Leu Ser   Thr His Pro 
    11765                 11770                 11775             


Arg Thr   Glu Thr Ser Lys Thr   Phe Pro Ala Ser Thr   Val Phe Pro 
    11780                 11785                 11790             


Gln Val   Ser Glu Thr Thr Ala   Ser Leu Thr Ile Arg   Pro Gly Ala 
    11795                 11800                 11805             


Glu Thr   Ser Thr Ala Leu Pro   Thr Gln Thr Thr Ser   Ser Leu Phe 
    11810                 11815                 11820             


Thr Leu   Leu Val Thr Gly Thr   Ser Arg Val Asp Leu   Ser Pro Thr 
    11825                 11830                 11835             


Ala Ser   Pro Gly Val Ser Ala   Lys Thr Ala Pro Leu   Ser Thr His 
    11840                 11845                 11850             


Pro Gly   Thr Glu Thr Ser Thr   Met Ile Pro Thr Ser   Thr Leu Ser 
    11855                 11860                 11865             


Leu Gly   Leu Leu Glu Thr Thr   Gly Leu Leu Ala Thr   Ser Ser Ser 
    11870                 11875                 11880             


Ala Glu   Thr Ser Thr Ser Thr   Leu Thr Leu Thr Val   Ser Pro Ala 
    11885                 11890                 11895             


Val Ser   Gly Leu Ser Ser Ala   Ser Ile Thr Thr Asp   Lys Pro Gln 
    11900                 11905                 11910             


Thr Val   Thr Ser Trp Asn Thr   Glu Thr Ser Pro Ser   Val Thr Ser 
    11915                 11920                 11925             


Val Gly   Pro Pro Glu Phe Ser   Arg Thr Val Thr Gly   Thr Thr Met 
    11930                 11935                 11940             


Thr Leu   Ile Pro Ser Glu Met   Pro Thr Pro Pro Lys   Thr Ser His 
    11945                 11950                 11955             


Gly Glu   Gly Val Ser Pro Thr   Thr Ile Leu Arg Thr   Thr Met Val 
    11960                 11965                 11970             


Glu Ala   Thr Asn Leu Ala Thr   Thr Gly Ser Ser Pro   Thr Val Ala 
    11975                 11980                 11985             


Lys Thr   Thr Thr Thr Phe Asn   Thr Leu Ala Gly Ser   Leu Phe Thr 
    11990                 11995                 12000             


Pro Leu   Thr Thr Pro Gly Met   Ser Thr Leu Ala Ser   Glu Ser Val 
    12005                 12010                 12015             


Thr Ser   Arg Thr Ser Tyr Asn   His Arg Ser Trp Ile   Ser Thr Thr 
    12020                 12025                 12030             


Ser Ser   Tyr Asn Arg Arg Tyr   Trp Thr Pro Ala Thr   Ser Thr Pro 
    12035                 12040                 12045             


Val Thr   Ser Thr Phe Ser Pro   Gly Ile Ser Thr Ser   Ser Ile Pro 
    12050                 12055                 12060             


Ser Ser   Thr Ala Ala Thr Val   Pro Phe Met Val Pro   Phe Thr Leu 
    12065                 12070                 12075             


Asn Phe   Thr Ile Thr Asn Leu   Gln Tyr Glu Glu Asp   Met Arg His 
    12080                 12085                 12090             


Pro Gly   Ser Arg Lys Phe Asn   Ala Thr Glu Arg Glu   Leu Gln Gly 
    12095                 12100                 12105             


Leu Leu   Lys Pro Leu Phe Arg   Asn Ser Ser Leu Glu   Tyr Leu Tyr 
    12110                 12115                 12120             


Ser Gly   Cys Arg Leu Ala Ser   Leu Arg Pro Glu Lys   Asp Ser Ser 
    12125                 12130                 12135             


Ala Thr   Ala Val Asp Ala Ile   Cys Thr His Arg Pro   Asp Pro Glu 
    12140                 12145                 12150             


Asp Leu   Gly Leu Asp Arg Glu   Arg Leu Tyr Trp Glu   Leu Ser Asn 
    12155                 12160                 12165             


Leu Thr   Asn Gly Ile Gln Glu   Leu Gly Pro Tyr Thr   Leu Asp Arg 
    12170                 12175                 12180             


Asn Ser   Leu Tyr Val Asn Gly   Phe Thr His Arg Ser   Ser Met Pro 
    12185                 12190                 12195             


Thr Thr   Ser Thr Pro Gly Thr   Ser Thr Val Asp Val   Gly Thr Ser 
    12200                 12205                 12210             


Gly Thr   Pro Ser Ser Ser Pro   Ser Pro Thr Thr Ala   Gly Pro Leu 
    12215                 12220                 12225             


Leu Met   Pro Phe Thr Leu Asn   Phe Thr Ile Thr Asn   Leu Gln Tyr 
    12230                 12235                 12240             


Glu Glu   Asp Met Arg Arg Thr   Gly Ser Arg Lys Phe   Asn Thr Met 
    12245                 12250                 12255             


Glu Ser   Val Leu Gln Gly Leu   Leu Lys Pro Leu Phe   Lys Asn Thr 
    12260                 12265                 12270             


Ser Val   Gly Pro Leu Tyr Ser   Gly Cys Arg Leu Thr   Leu Leu Arg 
    12275                 12280                 12285             


Pro Glu   Lys Asp Gly Ala Ala   Thr Gly Val Asp Ala   Ile Cys Thr 
    12290                 12295                 12300             


His Arg   Leu Asp Pro Lys Ser   Pro Gly Leu Asn Arg   Glu Gln Leu 
    12305                 12310                 12315             


Tyr Trp   Glu Leu Ser Lys Leu   Thr Asn Asp Ile Glu   Glu Leu Gly 
    12320                 12325                 12330             


Pro Tyr   Thr Leu Asp Arg Asn   Ser Leu Tyr Val Asn   Gly Phe Thr 
    12335                 12340                 12345             


His Gln   Ser Ser Val Ser Thr   Thr Ser Thr Pro Gly   Thr Ser Thr 
    12350                 12355                 12360             


Val Asp   Leu Arg Thr Ser Gly   Thr Pro Ser Ser Leu   Ser Ser Pro 
    12365                 12370                 12375             


Thr Ile   Met Ala Ala Gly Pro   Leu Leu Val Pro Phe   Thr Leu Asn 
    12380                 12385                 12390             


Phe Thr   Ile Thr Asn Leu Gln   Tyr Gly Glu Asp Met   Gly His Pro 
    12395                 12400                 12405             


Gly Ser   Arg Lys Phe Asn Thr   Thr Glu Arg Val Leu   Gln Gly Leu 
    12410                 12415                 12420             


Leu Gly   Pro Ile Phe Lys Asn   Thr Ser Val Gly Pro   Leu Tyr Ser 
    12425                 12430                 12435             


Gly Cys   Arg Leu Thr Ser Leu   Arg Ser Glu Lys Asp   Gly Ala Ala 
    12440                 12445                 12450             


Thr Gly   Val Asp Ala Ile Cys   Ile His His Leu Asp   Pro Lys Ser 
    12455                 12460                 12465             


Pro Gly   Leu Asn Arg Glu Arg   Leu Tyr Trp Glu Leu   Ser Gln Leu 
    12470                 12475                 12480             


Thr Asn   Gly Ile Lys Glu Leu   Gly Pro Tyr Thr Leu   Asp Arg Asn 
    12485                 12490                 12495             


Ser Leu   Tyr Val Asn Gly Phe   Thr His Arg Thr Ser   Val Pro Thr 
    12500                 12505                 12510             


Ser Ser   Thr Pro Gly Thr Ser   Thr Val Asp Leu Gly   Thr Ser Gly 
    12515                 12520                 12525             


Thr Pro   Phe Ser Leu Pro Ser   Pro Ala Thr Ala Gly   Pro Leu Leu 
    12530                 12535                 12540             


Val Leu   Phe Thr Leu Asn Phe   Thr Ile Thr Asn Leu   Lys Tyr Glu 
    12545                 12550                 12555             


Glu Asp   Met His Arg Pro Gly   Ser Arg Lys Phe Asn   Thr Thr Glu 
    12560                 12565                 12570             


Arg Val   Leu Gln Thr Leu Leu   Gly Pro Met Phe Lys   Asn Thr Ser 
    12575                 12580                 12585             


Val Gly   Leu Leu Tyr Ser Gly   Cys Arg Leu Thr Leu   Leu Arg Ser 
    12590                 12595                 12600             


Glu Lys   Asp Gly Ala Ala Thr   Gly Val Asp Ala Ile   Cys Thr His 
    12605                 12610                 12615             


Arg Leu   Asp Pro Lys Ser Pro   Gly Val Asp Arg Glu   Gln Leu Tyr 
    12620                 12625                 12630             


Trp Glu   Leu Ser Gln Leu Thr   Asn Gly Ile Lys Glu   Leu Gly Pro 
    12635                 12640                 12645             


Tyr Thr   Leu Asp Arg Asn Ser   Leu Tyr Val Asn Gly   Phe Thr His 
    12650                 12655                 12660             


Trp Ile   Pro Val Pro Thr Ser   Ser Thr Pro Gly Thr   Ser Thr Val 
    12665                 12670                 12675             


Asp Leu   Gly Ser Gly Thr Pro   Ser Ser Leu Pro Ser   Pro Thr Thr 
    12680                 12685                 12690             


Ala Gly   Pro Leu Leu Val Pro   Phe Thr Leu Asn Phe   Thr Ile Thr 
    12695                 12700                 12705             


Asn Leu   Lys Tyr Glu Glu Asp   Met His Cys Pro Gly   Ser Arg Lys 
    12710                 12715                 12720             


Phe Asn   Thr Thr Glu Arg Val   Leu Gln Ser Leu Leu   Gly Pro Met 
    12725                 12730                 12735             


Phe Lys   Asn Thr Ser Val Gly   Pro Leu Tyr Ser Gly   Cys Arg Leu 
    12740                 12745                 12750             


Thr Leu   Leu Arg Ser Glu Lys   Asp Gly Ala Ala Thr   Gly Val Asp 
    12755                 12760                 12765             


Ala Ile   Cys Thr His Arg Leu   Asp Pro Lys Ser Pro   Gly Val Asp 
    12770                 12775                 12780             


Arg Glu   Gln Leu Tyr Trp Glu   Leu Ser Gln Leu Thr   Asn Gly Ile 
    12785                 12790                 12795             


Lys Glu   Leu Gly Pro Tyr Thr   Leu Asp Arg Asn Ser   Leu Tyr Val 
    12800                 12805                 12810             


Asn Gly   Phe Thr His Gln Thr   Ser Ala Pro Asn Thr   Ser Thr Pro 
    12815                 12820                 12825             


Gly Thr   Ser Thr Val Asp Leu   Gly Thr Ser Gly Thr   Pro Ser Ser 
    12830                 12835                 12840             


Leu Pro   Ser Pro Thr Ser Ala   Gly Pro Leu Leu Val   Pro Phe Thr 
    12845                 12850                 12855             


Leu Asn   Phe Thr Ile Thr Asn   Leu Gln Tyr Glu Glu   Asp Met His 
    12860                 12865                 12870             


His Pro   Gly Ser Arg Lys Phe   Asn Thr Thr Glu Arg   Val Leu Gln 
    12875                 12880                 12885             


Gly Leu   Leu Gly Pro Met Phe   Lys Asn Thr Ser Val   Gly Leu Leu 
    12890                 12895                 12900             


Tyr Ser   Gly Cys Arg Leu Thr   Leu Leu Arg Pro Glu   Lys Asn Gly 
    12905                 12910                 12915             


Ala Ala   Thr Gly Met Asp Ala   Ile Cys Ser His Arg   Leu Asp Pro 
    12920                 12925                 12930             


Lys Ser   Pro Gly Leu Asn Arg   Glu Gln Leu Tyr Trp   Glu Leu Ser 
    12935                 12940                 12945             


Gln Leu   Thr His Gly Ile Lys   Glu Leu Gly Pro Tyr   Thr Leu Asp 
    12950                 12955                 12960             


Arg Asn   Ser Leu Tyr Val Asn   Gly Phe Thr His Arg   Ser Ser Val 
    12965                 12970                 12975             


Ala Pro   Thr Ser Thr Pro Gly   Thr Ser Thr Val Asp   Leu Gly Thr 
    12980                 12985                 12990             


Ser Gly   Thr Pro Ser Ser Leu   Pro Ser Pro Thr Thr   Ala Val Pro 
    12995                 13000                 13005             


Leu Leu   Val Pro Phe Thr Leu   Asn Phe Thr Ile Thr   Asn Leu Gln 
    13010                 13015                 13020             


Tyr Gly   Glu Asp Met Arg His   Pro Gly Ser Arg Lys   Phe Asn Thr 
    13025                 13030                 13035             


Thr Glu   Arg Val Leu Gln Gly   Leu Leu Gly Pro Leu   Phe Lys Asn 
    13040                 13045                 13050             


Ser Ser   Val Gly Pro Leu Tyr   Ser Gly Cys Arg Leu   Ile Ser Leu 
    13055                 13060                 13065             


Arg Ser   Glu Lys Asp Gly Ala   Ala Thr Gly Val Asp   Ala Ile Cys 
    13070                 13075                 13080             


Thr His   His Leu Asn Pro Gln   Ser Pro Gly Leu Asp   Arg Glu Gln 
    13085                 13090                 13095             


Leu Tyr   Trp Gln Leu Ser Gln   Met Thr Asn Gly Ile   Lys Glu Leu 
    13100                 13105                 13110             


Gly Pro   Tyr Thr Leu Asp Arg   Asn Ser Leu Tyr Val   Asn Gly Phe 
    13115                 13120                 13125             


Thr His   Arg Ser Ser Gly Leu   Thr Thr Ser Thr Pro   Trp Thr Ser 
    13130                 13135                 13140             


Thr Val   Asp Leu Gly Thr Ser   Gly Thr Pro Ser Pro   Val Pro Ser 
    13145                 13150                 13155             


Pro Thr   Thr Thr Gly Pro Leu   Leu Val Pro Phe Thr   Leu Asn Phe 
    13160                 13165                 13170             


Thr Ile   Thr Asn Leu Gln Tyr   Glu Glu Asn Met Gly   His Pro Gly 
    13175                 13180                 13185             


Ser Arg   Lys Phe Asn Ile Thr   Glu Ser Val Leu Gln   Gly Leu Leu 
    13190                 13195                 13200             


Lys Pro   Leu Phe Lys Ser Thr   Ser Val Gly Pro Leu   Tyr Ser Gly 
    13205                 13210                 13215             


Cys Arg   Leu Thr Leu Leu Arg   Pro Glu Lys Asp Gly   Val Ala Thr 
    13220                 13225                 13230             


Arg Val   Asp Ala Ile Cys Thr   His Arg Pro Asp Pro   Lys Ile Pro 
    13235                 13240                 13245             


Gly Leu   Asp Arg Gln Gln Leu   Tyr Trp Glu Leu Ser   Gln Leu Thr 
    13250                 13255                 13260             


His Ser   Ile Thr Glu Leu Gly   Pro Tyr Thr Leu Asp   Arg Asp Ser 
    13265                 13270                 13275             


Leu Tyr   Val Asn Gly Phe Thr   Gln Arg Ser Ser Val   Pro Thr Thr 
    13280                 13285                 13290             


Ser Thr   Pro Gly Thr Phe Thr   Val Gln Pro Glu Thr   Ser Glu Thr 
    13295                 13300                 13305             


Pro Ser   Ser Leu Pro Gly Pro   Thr Ala Thr Gly Pro   Val Leu Leu 
    13310                 13315                 13320             


Pro Phe   Thr Leu Asn Phe Thr   Ile Thr Asn Leu Gln   Tyr Glu Glu 
    13325                 13330                 13335             


Asp Met   Arg Arg Pro Gly Ser   Arg Lys Phe Asn Thr   Thr Glu Arg 
    13340                 13345                 13350             


Val Leu   Gln Gly Leu Leu Met   Pro Leu Phe Lys Asn   Thr Ser Val 
    13355                 13360                 13365             


Ser Ser   Leu Tyr Ser Gly Cys   Arg Leu Thr Leu Leu   Arg Pro Glu 
    13370                 13375                 13380             


Lys Asp   Gly Ala Ala Thr Arg   Val Asp Ala Val Cys   Thr His Arg 
    13385                 13390                 13395             


Pro Asp   Pro Lys Ser Pro Gly   Leu Asp Arg Glu Arg   Leu Tyr Trp 
    13400                 13405                 13410             


Lys Leu   Ser Gln Leu Thr His   Gly Ile Thr Glu Leu   Gly Pro Tyr 
    13415                 13420                 13425             


Thr Leu   Asp Arg His Ser Leu   Tyr Val Asn Gly Phe   Thr His Gln 
    13430                 13435                 13440             


Ser Ser   Met Thr Thr Thr Arg   Thr Pro Asp Thr Ser   Thr Met His 
    13445                 13450                 13455             


Leu Ala   Thr Ser Arg Thr Pro   Ala Ser Leu Ser Gly   Pro Met Thr 
    13460                 13465                 13470             


Ala Ser   Pro Leu Leu Val Leu   Phe Thr Ile Asn Phe   Thr Ile Thr 
    13475                 13480                 13485             


Asn Leu   Arg Tyr Glu Glu Asn   Met His His Pro Gly   Ser Arg Lys 
    13490                 13495                 13500             


Phe Asn   Thr Thr Glu Arg Val   Leu Gln Gly Leu Leu   Arg Pro Val 
    13505                 13510                 13515             


Phe Lys   Asn Thr Ser Val Gly   Pro Leu Tyr Ser Gly   Cys Arg Leu 
    13520                 13525                 13530             


Thr Leu   Leu Arg Pro Lys Lys   Asp Gly Ala Ala Thr   Lys Val Asp 
    13535                 13540                 13545             


Ala Ile   Cys Thr Tyr Arg Pro   Asp Pro Lys Ser Pro   Gly Leu Asp 
    13550                 13555                 13560             


Arg Glu   Gln Leu Tyr Trp Glu   Leu Ser Gln Leu Thr   His Ser Ile 
    13565                 13570                 13575             


Thr Glu   Leu Gly Pro Tyr Thr   Leu Asp Arg Asp Ser   Leu Tyr Val 
    13580                 13585                 13590             


Asn Gly   Phe Thr Gln Arg Ser   Ser Val Pro Thr Thr   Ser Ile Pro 
    13595                 13600                 13605             


Gly Thr   Pro Thr Val Asp Leu   Gly Thr Ser Gly Thr   Pro Val Ser 
    13610                 13615                 13620             


Lys Pro   Gly Pro Ser Ala Ala   Ser Pro Leu Leu Val   Leu Phe Thr 
    13625                 13630                 13635             


Leu Asn   Phe Thr Ile Thr Asn   Leu Arg Tyr Glu Glu   Asn Met Gln 
    13640                 13645                 13650             


His Pro   Gly Ser Arg Lys Phe   Asn Thr Thr Glu Arg   Val Leu Gln 
    13655                 13660                 13665             


Gly Leu   Leu Arg Ser Leu Phe   Lys Ser Thr Ser Val   Gly Pro Leu 
    13670                 13675                 13680             


Tyr Ser   Gly Cys Arg Leu Thr   Leu Leu Arg Pro Glu   Lys Asp Gly 
    13685                 13690                 13695             


Thr Ala   Thr Gly Val Asp Ala   Ile Cys Thr His His   Pro Asp Pro 
    13700                 13705                 13710             


Lys Ser   Pro Arg Leu Asp Arg   Glu Gln Leu Tyr Trp   Glu Leu Ser 
    13715                 13720                 13725             


Gln Leu   Thr His Asn Ile Thr   Glu Leu Gly Pro Tyr   Ala Leu Asp 
    13730                 13735                 13740             


Asn Asp   Ser Leu Phe Val Asn   Gly Phe Thr His Arg   Ser Ser Val 
    13745                 13750                 13755             


Ser Thr   Thr Ser Thr Pro Gly   Thr Pro Thr Val Tyr   Leu Gly Ala 
    13760                 13765                 13770             


Ser Lys   Thr Pro Ala Ser Ile   Phe Gly Pro Ser Ala   Ala Ser His 
    13775                 13780                 13785             


Leu Leu   Ile Leu Phe Thr Leu   Asn Phe Thr Ile Thr   Asn Leu Arg 
    13790                 13795                 13800             


Tyr Glu   Glu Asn Met Trp Pro   Gly Ser Arg Lys Phe   Asn Thr Thr 
    13805                 13810                 13815             


Glu Arg   Val Leu Gln Gly Leu   Leu Arg Pro Leu Phe   Lys Asn Thr 
    13820                 13825                 13830             


Ser Val   Gly Pro Leu Tyr Ser   Gly Cys Arg Leu Thr   Leu Leu Arg 
    13835                 13840                 13845             


Pro Glu   Lys Asp Gly Glu Ala   Thr Gly Val Asp Ala   Ile Cys Thr 
    13850                 13855                 13860             


His Arg   Pro Asp Pro Thr Gly   Pro Gly Leu Asp Arg   Glu Gln Leu 
    13865                 13870                 13875             


Tyr Leu   Glu Leu Ser Gln Leu   Thr His Ser Ile Thr   Glu Leu Gly 
    13880                 13885                 13890             


Pro Tyr   Thr Leu Asp Arg Asp   Ser Leu Tyr Val Asn   Gly Phe Thr 
    13895                 13900                 13905             


His Arg   Ser Ser Val Pro Thr   Thr Ser Thr Gly Val   Val Ser Glu 
    13910                 13915                 13920             


Glu Pro   Phe Thr Leu Asn Phe   Thr Ile Asn Asn Leu   Arg Tyr Met 
    13925                 13930                 13935             


Ala Asp   Met Gly Gln Pro Gly   Ser Leu Lys Phe Asn   Ile Thr Asp 
    13940                 13945                 13950             


Asn Val   Met Gln His Leu Leu   Ser Pro Leu Phe Gln   Arg Ser Ser 
    13955                 13960                 13965             


Leu Gly   Ala Arg Tyr Thr Gly   Cys Arg Val Ile Ala   Leu Arg Ser 
    13970                 13975                 13980             


Val Lys   Asn Gly Ala Glu Thr   Arg Val Asp Leu Leu   Cys Thr Tyr 
    13985                 13990                 13995             


Leu Gln   Pro Leu Ser Gly Pro   Gly Leu Pro Ile Lys   Gln Val Phe 
    14000                 14005                 14010             


His Glu   Leu Ser Gln Gln Thr   His Gly Ile Thr Arg   Leu Gly Pro 
    14015                 14020                 14025             


Tyr Ser   Leu Asp Lys Asp Ser   Leu Tyr Leu Asn Gly   Tyr Asn Glu 
    14030                 14035                 14040             


Pro Gly   Pro Asp Glu Pro Pro   Thr Thr Pro Lys Pro   Ala Thr Thr 
    14045                 14050                 14055             


Phe Leu   Pro Pro Leu Ser Glu   Ala Thr Thr Ala Met   Gly Tyr His 
    14060                 14065                 14070             


Leu Lys   Thr Leu Thr Leu Asn   Phe Thr Ile Ser Asn   Leu Gln Tyr 
    14075                 14080                 14085             


Ser Pro   Asp Met Gly Lys Gly   Ser Ala Thr Phe Asn   Ser Thr Glu 
    14090                 14095                 14100             


Gly Val   Leu Gln His Leu Leu   Arg Pro Leu Phe Gln   Lys Ser Ser 
    14105                 14110                 14115             


Met Gly   Pro Phe Tyr Leu Gly   Cys Gln Leu Ile Ser   Leu Arg Pro 
    14120                 14125                 14130             


Glu Lys   Asp Gly Ala Ala Thr   Gly Val Asp Thr Thr   Cys Thr Tyr 
    14135                 14140                 14145             


His Pro   Asp Pro Val Gly Pro   Gly Leu Asp Ile Gln   Gln Leu Tyr 
    14150                 14155                 14160             


Trp Glu   Leu Ser Gln Leu Thr   His Gly Val Thr Gln   Leu Gly Phe 
    14165                 14170                 14175             


Tyr Val   Leu Asp Arg Asp Ser   Leu Phe Ile Asn Gly   Tyr Ala Pro 
    14180                 14185                 14190             


Gln Asn   Leu Ser Ile Arg Gly   Glu Tyr Gln Ile Asn   Phe His Ile 
    14195                 14200                 14205             


Val Asn   Trp Asn Leu Ser Asn   Pro Asp Pro Thr Ser   Ser Glu Tyr 
    14210                 14215                 14220             


Ile Thr   Leu Leu Arg Asp Ile   Gln Asp Lys Val Thr   Thr Leu Tyr 
    14225                 14230                 14235             


Lys Gly   Ser Gln Leu His Asp   Thr Phe Arg Phe Cys   Leu Val Thr 
    14240                 14245                 14250             


Asn Leu   Thr Met Asp Ser Val   Leu Val Thr Val Lys   Ala Leu Phe 
    14255                 14260                 14265             


Ser Ser   Asn Leu Asp Pro Ser   Leu Val Glu Gln Val   Phe Leu Asp 
    14270                 14275                 14280             


Lys Thr   Leu Asn Ala Ser Phe   His Trp Leu Gly Ser   Thr Tyr Gln 
    14285                 14290                 14295             


Leu Val   Asp Ile His Val Thr   Glu Met Glu Ser Ser   Val Tyr Gln 
    14300                 14305                 14310             


Pro Thr   Ser Ser Ser Ser Thr   Gln His Phe Tyr Leu   Asn Phe Thr 
    14315                 14320                 14325             


Ile Thr   Asn Leu Pro Tyr Ser   Gln Asp Lys Ala Gln   Pro Gly Thr 
    14330                 14335                 14340             


Thr Asn   Tyr Gln Arg Asn Lys   Arg Asn Ile Glu Asp   Ala Leu Asn 
    14345                 14350                 14355             


Gln Leu   Phe Arg Asn Ser Ser   Ile Lys Ser Tyr Phe   Ser Asp Cys 
    14360                 14365                 14370             


Gln Val   Ser Thr Phe Arg Ser   Val Pro Asn Arg His   His Thr Gly 
    14375                 14380                 14385             


Val Asp   Ser Leu Cys Asn Phe   Ser Pro Leu Ala Arg   Arg Val Asp 
    14390                 14395                 14400             


Arg Val   Ala Ile Tyr Glu Glu   Phe Leu Arg Met Thr   Arg Asn Gly 
    14405                 14410                 14415             


Thr Gln   Leu Gln Asn Phe Thr   Leu Asp Arg Ser Ser   Val Leu Val 
    14420                 14425                 14430             


Asp Gly   Tyr Ser Pro Asn Arg   Asn Glu Pro Leu Thr   Gly Asn Ser 
    14435                 14440                 14445             


Asp Leu   Pro Phe Trp Ala Val   Ile Leu Ile Gly Leu   Ala Gly Leu 
    14450                 14455                 14460             


Leu Gly   Val Ile Thr Cys Leu   Ile Cys Gly Val Leu   Val Thr Thr 
    14465                 14470                 14475             


Arg Arg   Arg Lys Lys Glu Gly   Glu Tyr Asn Val Gln   Gln Gln Cys 
    14480                 14485                 14490             


Pro Gly   Tyr Tyr Gln Ser His   Leu Asp Leu Glu Asp   Leu Gln 
    14495                 14500                 14505         


<210>  1151
<211>  1899
<212>  DNA
<213>  Homo sapiens

<400>  1151
ggtcgggacg ccgggctagg ggcgcgtcat gtggccgctc acggtcccgc cgccgctgct     60

gctgctgctg tgctcaggcc tggccggaca gactctcttc cagaacccag aagagggctg    120

gcagctgtac acctcagccc aggcccctga cgggaaatgc atctgcacgg ccgtgatccc    180

agcgcagagt acctgctctc gagatggcag gagtcgggag ctgcggcaac tgatggagaa    240

ggtccagaac gtctcccagt ccatggaggt ccttgagttg cggacgtatc gcgacctcca    300

gtatgtacgc ggcatggaga ccctcatgcg gagcctggat gcgcggctcc gggcagctga    360

tgggtccctc tcggccaaga gcttccagga gctgaaggac aggatgacgg aactgttgcc    420

cctgagctcg gtcctggagc agtacaaggc agacacgcgg accattgtac gcttgcggga    480

ggaggtgagg aatctctccg gcagtctggc ggccattcag gaggagatgg gtgcctacgg    540

gtatgaggac ctgcagcaac gggtgatggc cctggaggcc cggctccacg cctgcgccca    600

gaagctgggc tgtgggaagc tgaccggggt cagtaacccc atcaccgttc gggccatggg    660

gtcccgcttc ggctcctgga tgactgacac gatggccccc agtgcggata gccgggtctg    720

gtacatggat ggctattaca aaggccgccg ggtcctggag ttccgtaccc tgggagactt    780

catcaaaggc cagaacttta tccagcacct gctgccccag ccgtgggcgg gcacgggcca    840

cgtggtgtac aacggctccc tgttctataa caagtaccag agcaacgtgg tggtcaaata    900

ccacttccgc tcgcgctctg tgctggtgca gaggagcctc ccgggcgccg gttacaacaa    960

caccttcccc tactcctggg gcggcttctc cgacatggac ttcatggtgg acgagagcgg   1020

gctctgggct gtgtacacca ccaaccagaa cgcgggcaac atcgtggtca gccggctgga   1080

cccgcacacc ctcgaggtca tgcggtcctg ggacaccggc taccccaagc gcagcgctgg   1140

cgaggccttc atgatctgcg gtgtgctcta cgtgaccaac tcccacctgg ctggggccaa   1200

ggtctacttc gcctatttta ccaacacgtc cagttacgag tacacggacg tgcccttcca   1260

caaccagtat tcccacatct cgatgctgga ttacaacccc cgggagcgcg ccctctatac   1320

ctggaacaac ggccaccagg tgctctacaa tgtcaccctg tttcacgtca tcagcacctc   1380

tggggacccc tgagccaatg ctgtggctcg ggctgctgcc tggggggcct ccgggggctg   1440

ggggcccttt tcattctgcc tgtgtccctc aagggtgatc tctctgtctc tgtcacgccc   1500

tttctccccg cctttttgct gggcttttgt tctctgccta tgtatttctg tctatttttt   1560

caatttcccc tcttctcctt tattgatctc tgcttttaat acaccacttc tttctttctg   1620

cctttttatg gatgtctttt tctttttatg gctctggttc tccagttctt tccgtctctg   1680

cctctctctg tctctctctc tctgtccttc cacccctccc tccttgcttc ccacccattc   1740

ctcatccctc actcccaccc ccacccccac ccccaggagt tgagtgcatg gatctgtttc   1800

tttttttatt tacacttttt ctttccggtt tgccggaata aacaggacct ttgacatttg   1860

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                          1899


<210>  1152
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  1152

Met Trp Pro Leu Thr Val Pro Pro Pro Leu Leu Leu Leu Leu Cys Ser 
1               5                   10                  15


Gly Leu Ala Gly Gln Thr Leu Phe Gln Asn Pro Glu Glu Gly Trp Gln 
            20                  25                  30


Leu Tyr Thr Ser Ala Gln Ala Pro Asp Gly Lys Cys Ile Cys Thr Ala 
        35                  40                  45


Val Ile Pro Ala Gln Ser Thr Cys Ser Arg Asp Gly Arg Ser Arg Glu 
    50                  55                  60


Leu Arg Gln Leu Met Glu Lys Val Gln Asn Val Ser Gln Ser Met Glu 
65                  70                  75                  80


Val Leu Glu Leu Arg Thr Tyr Arg Asp Leu Gln Tyr Val Arg Gly Met 
                85                  90                  95


Glu Thr Leu Met Arg Ser Leu Asp Ala Arg Leu Arg Ala Ala Asp Gly 
            100                 105                 110


Ser Leu Ser Ala Lys Ser Phe Gln Glu Leu Lys Asp Arg Met Thr Glu 
        115                 120                 125


Leu Leu Pro Leu Ser Ser Val Leu Glu Gln Tyr Lys Ala Asp Thr Arg 
    130                 135                 140


Thr Ile Val Arg Leu Arg Glu Glu Val Arg Asn Leu Ser Gly Ser Leu 
145                 150                 155                 160


Ala Ala Ile Gln Glu Glu Met Gly Ala Tyr Gly Tyr Glu Asp Leu Gln 
                165                 170                 175


Gln Arg Val Met Ala Leu Glu Ala Arg Leu His Ala Cys Ala Gln Lys 
            180                 185                 190


Leu Gly Cys Gly Lys Leu Thr Gly Val Ser Asn Pro Ile Thr Val Arg 
        195                 200                 205


Ala Met Gly Ser Arg Phe Gly Ser Trp Met Thr Asp Thr Met Ala Pro 
    210                 215                 220


Ser Ala Asp Ser Arg Val Trp Tyr Met Asp Gly Tyr Tyr Lys Gly Arg 
225                 230                 235                 240


Arg Val Leu Glu Phe Arg Thr Leu Gly Asp Phe Ile Lys Gly Gln Asn 
                245                 250                 255


Phe Ile Gln His Leu Leu Pro Gln Pro Trp Ala Gly Thr Gly His Val 
            260                 265                 270


Val Tyr Asn Gly Ser Leu Phe Tyr Asn Lys Tyr Gln Ser Asn Val Val 
        275                 280                 285


Val Lys Tyr His Phe Arg Ser Arg Ser Val Leu Val Gln Arg Ser Leu 
    290                 295                 300


Pro Gly Ala Gly Tyr Asn Asn Thr Phe Pro Tyr Ser Trp Gly Gly Phe 
305                 310                 315                 320


Ser Asp Met Asp Phe Met Val Asp Glu Ser Gly Leu Trp Ala Val Tyr 
                325                 330                 335


Thr Thr Asn Gln Asn Ala Gly Asn Ile Val Val Ser Arg Leu Asp Pro 
            340                 345                 350


His Thr Leu Glu Val Met Arg Ser Trp Asp Thr Gly Tyr Pro Lys Arg 
        355                 360                 365


Ser Ala Gly Glu Ala Phe Met Ile Cys Gly Val Leu Tyr Val Thr Asn 
    370                 375                 380


Ser His Leu Ala Gly Ala Lys Val Tyr Phe Ala Tyr Phe Thr Asn Thr 
385                 390                 395                 400


Ser Ser Tyr Glu Tyr Thr Asp Val Pro Phe His Asn Gln Tyr Ser His 
                405                 410                 415


Ile Ser Met Leu Asp Tyr Asn Pro Arg Glu Arg Ala Leu Tyr Thr Trp 
            420                 425                 430


Asn Asn Gly His Gln Val Leu Tyr Asn Val Thr Leu Phe His Val Ile 
        435                 440                 445


Ser Thr Ser Gly Asp Pro 
    450


<210>  1153
<211>  6192
<212>  DNA
<213>  Homo sapiens

<400>  1153
gcgagtgact gcaccgagcc cgagaagtcg ccgcgccccg cagccgcccc gactggttcc     60

ccgccttgcc cgtgggcccc gccgggatgg ggaaccgccg ggacctgggc cagccgcggg    120

ccggtctctg cctgctcctg gccgcgctgc agcttctgcc ggggacgcag gccgatcctg    180

tggatgtcct gaaggccctg ggtgtgcagg gaggccaggc tggggtcccc gaggggcctg    240

gcttctgtcc ccagaggact ccagagggtg accgggcatt cagaattggc caggccagca    300

cgctcggcat ccccacgtgg gaactctttc cagaaggcca ctttcctgag aacttctcct    360

tgctgatcac cttgcgggga cagccagcca atcagtctgt cctgctgtcc atttatgatg    420

aaaggggtgc ccggcagttg ggcctggcac tggggccagc gctgggtctc ctaggtgacc    480

ccttccgccc cctcccccag caggtcaacc tcacagatgg caggtggcac cgtgtggccg    540

tcagcataga tggtgagatg gtgaccctgg tagctgactg tgaagctcag ccccctgttt    600

tgggccatgg cccccgcttc atcagcatag ctggactcac tgtgctgggg acccaggacc    660

ttggggaaaa gactttcgag ggagacattc aggagctgct gataagccca gatcctcagg    720

ctgccttcca ggcttgtgag cggtacctcc ccgactgtga caacctggca ccggcagcca    780

cagtggctcc ccagggtgaa ccagaaaccc ctcgtcctcg gcggaagggg aagggaaaag    840

ggaggaagaa agggcgaggt cgcaagggga agggcaggaa aaagaacaag gaaatttgga    900

cctcaagtcc acctcctgac tccgcagaga accagacctc cactgacatc cccaagacag    960

agactccagc tccaaatctg cctccgaccc ccacgccttt ggtcgtcacc tccactgtga   1020

ctactggact caatgccacg atcctagaga ggagcttgga ccctgacagt ggaaccgagc   1080

tggggaccct ggagaccaag gcagccaggg aggatgaaga aggagatgat tccaccatgg   1140

gccctgactt ccgggcagca gaatatccat ctcggactca gttccagatc tttcctggtg   1200

ctggagagaa aggagcaaaa ggagagcccg cagtgattga aaaggggcag cagtttgagg   1260

gacctccagg agccccagga ccccaagggg tggttggccc ctcaggccct cccggccccc   1320

caggattccc tggcgaccct ggtccaccgg gccctgctgg cctcccagga atccccggca   1380

ttgatgggat ccgaggccca ccgggcactg tgatcatgat gccgttccag tttgcaggcg   1440

gctcctttaa aggcccccca gtctcattcc agcaggccca ggctcaggca gttctgcagc   1500

agactcagct ctctatgaaa ggcccccctg gtccagtggg gctcactggg cgcccaggcc   1560

ctgtgggtct ccccgggcat ccaggtctga aaggagagga gggagcagaa gggccacagg   1620

gtccccgagg cctgcaggga cctcatggac cccctggccg agtgggcaag atgggccgcc   1680

ctggagcaga tggagctcgg ggcctcccag gggacactgg acctaagggt gatcgtggct   1740

tcgatggcct ccctgggctg cctggtgaga agggccaaag gggtgacttt ggccatgtgg   1800

ggcaacccgg tcccccagga gaggatggtg agaggggagc agagggacct ccagggccca   1860

ctggccaggc tggggagccg ggtccacgag gactgcttgg ccccagaggc tctcctggcc   1920

ccacgggtcg cccgggtgtg actggaattg atggtgctcc tggtgccaaa ggcaatgtgg   1980

gtcctccagg agaaccaggc cctccgggac agcagggaaa ccatgggtcc cagggactcc   2040

ccggtcccca gggactcatt ggcactcctg gggagaaggg tccccctgga aacccaggaa   2100

ttccaggcct cccaggatcc gatggccctc tgggtcaccc aggacatgag ggccccacgg   2160

gagagaaagg ggctcagggt ccaccagggt cggcaggccc tccgggctat cctggacctc   2220

ggggagtgaa gggcacttca ggcaaccggg gcctccaggg ggagaaaggc gagaagggag   2280

aggacggctt cccaggcttc aagggcgatg tggggctcaa aggtgatcag gggaaacccg   2340

gagctccagg tccccgggga gaggatggtc ctgaggggcc gaaggggcag gcggggcagg   2400

ctggcgagga ggggccccca ggctcagctg gggagaaggg caagcttggg gtgccaggcc   2460

tcccaggtta tccaggacgc cctggaccta agggatctat tggatttccc ggtcccctgg   2520

gacccatagg agagaaaggg aagtcgggaa agacagggca gccaggcctg gaaggagagc   2580

ggggaccacc aggttcccgt ggagagaggg ggcaaccggg tgccacaggg caaccaggcc   2640

ccaagggcga tgtgggccag gatggagccc ctgggatccc tggagaaaag ggcctccctg   2700

gtctgcaagg ccctccagga ttccctgggc caaagggccc ccctggtcac caaggtaaag   2760

atgggcgacc agggcaccct ggacagagag gagaactggg cttccaaggt cagacaggcc   2820

cgcctggacc agctggtgtc ttaggccctc agggaaagac aggagaagtg ggacctctag   2880

gtgaaagggg gcctccaggc ccccctggac ctcctggtga acaaggtctt cctggcctgg   2940

aaggcagaga gggggccaag ggggaactgg gaccaccagg accccttggg aaagaagggc   3000

cagctggact caggggcttt cccggcccca aagggggccc tggggacccg ggacctactg   3060

gcttaaaggg tgataagggc cccccagggc ccgtgggggc caatggctcc cctggtgagc   3120

gcggtccttt gggcccagca ggaggcattg gacttcctgg ccaaagtggc agcgaaggcc   3180

ccgttggccc tgcaggcaag aaggggtccc ggggagaacg tggcccccct ggccccactg   3240

gcaaagatgg gatcccaggg cccctggggc ctctgggacc ccctggagct gctgggcctt   3300

ctggcgagga aggggacaag ggggatgtgg gtgcccccgg acacaagggg agtaaaggcg   3360

ataaaggaga cgcgggccca cctggacaac cagggatacg gggtcctgca ggacacccag   3420

gtcccccggg agcagacggg gctcaggggc gccggggacc cccaggcctc tttgggcaga   3480

aaggagatga cggagtcaga ggctttgtgg gggtgattgg ccctcctgga ctgcaggggc   3540

tgccaggccc tccgggagag aaaggggagg tcggagacgt cgggtccatg ggtccccatg   3600

gagctccagg tcctcggggt ccccaaggcc ccactggatc agagggcact ccagggctgc   3660

ctggaggagt tggtcagcca ggcgccgtgg gtgagaaggg tgagcgaggg gacgctggag   3720

acccagggcc tccaggagcc ccaggcatcc cggggcccaa gggagacatt ggtgaaaagg   3780

gggactcagg cccatctgga gctgctggac ccccaggcaa gaaaggtccc cctggagagg   3840

atggagccaa agggagcgtg ggccccacgg ggctgcccgg agatctaggg cccccaggag   3900

accctggagt ttcaggcata gatggttccc caggggagaa gggagaccct ggtgatgttg   3960

ggggaccggg tccgcctgga gcttctgggg agcccggcgc ccccgggccc cccggcaaga   4020

ggggtccttc aggccacatg ggtcgagaag gcagagaagg ggagaaaggt gccaaggggg   4080

agccaggtcc tgatgggccc ccagggagga cgggtccaat gggggctaga gggccccctg   4140

gacgtgtggg gcctgagggt cttcgaggga tccctggccc tgtgggtgaa ccaggcctcc   4200

tgggagcccc tggacagatg ggccctcctg gccccctggg gccctctggc ctcccagggc   4260

tgaagggaga cactggcccc aagggggaaa agggccacat tggattgatc ggtctcattg   4320

gccccccggg agaagctggt gagaaaggag atcaggggtt gccaggcgtg cagggacccc   4380

ctggtcccaa gggagaccct ggtccccctg gtcccattgg ctctctgggc caccctgggc   4440

ccccaggtgt ggcgggccct ctaggacaga aaggctcaaa agggtctccg gggtccatgg   4500

gcccccgtgg agacactgga cctgcaggcc caccaggccc cccgggtgcc cctgccgagc   4560

tgcatgggct gcgcaggcgc cggcgcttcg tcccagtccc gcttccagtc gtggagggcg   4620

gcctggagga ggtgctggcc tcgctcacat cgctgagctt ggagctggag cagctgcggc   4680

gtcctcccgg cactgcggag cgcccgggcc tcgtgtgcca cgagctgcac cgcaaccacc   4740

cgcacctgcc tgatggggaa tactggattg accccaacca gggctgcgcg cgggactcgt   4800

tcagggtttt ttgcaacttc acggcgggag gagagacctg cctctatccc gacaagaagt   4860

ttgagatcgt gaaattggcc tcctggtcca aggaaaagcc tggaggctgg tatagcacat   4920

tccgtcgagg gaagaagttc tcctacgtgg acgccgacgg gtccccagtg aatgtcgtgc   4980

agctgaactt cctgaaactg ctgagtgcca cagctcgcca gaacttcacc tactcctgcc   5040

agaatgcagc tgcctggctg gacgaagcca cgggtgacta cagccactcc gcccgcttcc   5100

ttggcaccaa tggagaggag ctgtctttca accagacgac agcagccact gtcagcgtcc   5160

cccaggatgg ctgccggctc cggaaaggac agacgaagac ccttttcgaa ttcagctctt   5220

ctcgagcggg atttctgccc ctgtgggatg tggcggccac tgactttggc cagacgaacc   5280

aaaagtttgg gtttgaactg ggccccgtct gcttcagcag ctgagagtgt ccggggtggg   5340

agggaccatg agggagcccc agaatggggt gcatttggtg ctgaggcttt gaagccaccg   5400

tatttttcgt tacctgtgac tatggagcca atgggatgtg acttcgctca tcacggacag   5460

tcattccttc tcctttccag ggtgctgggg gctggggttc cctggcccaa gggtccagcc   5520

tcctctcacc ccattccagg tggcatactg cagtctggct ctttctcccc tccctcccca   5580

cccaagcctc acctccccac cccttgaacc cccatgcaat gagcttctaa ctcagagctg   5640

atgaacaaaa gcccccccac ccccaatgcc tgcctcctca ctcctccgtc gctgcccttc   5700

acaccttttg gtgctacccc tccccagagt taagcactgg atgtctcctg atcccaggct   5760

gggaccccta cccccacccc ctttgatcct ttctacttcc acggtgaaag gactgaggtc   5820

ggactacaga gggaagaggg acttcccttg actgggttgt gtttcttttc ctgcctcagc   5880

ccagctctgc aaatcccctc cccctgcccc ccacctcccc aggctcacct tgccatgcca   5940

ggtggtttgg ggaccaagat gttggggggg tgaatcagga tcctaatggt gctgccctat   6000

ttatacctgg gtctgtatta aaagggaaag tcccccctgt tgtagatttc atctgcttcc   6060

tccttaggga aggctgggat atgatgagag attccagccc aagcctggcc ccccaccgcc   6120

aggccatagg gcataatttg catctcaaat ctgagaataa actgatgaac tgtgaaaaaa   6180

aaaaaaaaaa aa                                                       6192


<210>  1154
<211>  1745
<212>  PRT
<213>  Homo sapiens

<400>  1154

Met Gly Asn Arg Arg Asp Leu Gly Gln Pro Arg Ala Gly Leu Cys Leu 
1               5                   10                  15


Leu Leu Ala Ala Leu Gln Leu Leu Pro Gly Thr Gln Ala Asp Pro Val 
            20                  25                  30


Asp Val Leu Lys Ala Leu Gly Val Gln Gly Gly Gln Ala Gly Val Pro 
        35                  40                  45


Glu Gly Pro Gly Phe Cys Pro Gln Arg Thr Pro Glu Gly Asp Arg Ala 
    50                  55                  60


Phe Arg Ile Gly Gln Ala Ser Thr Leu Gly Ile Pro Thr Trp Glu Leu 
65                  70                  75                  80


Phe Pro Glu Gly His Phe Pro Glu Asn Phe Ser Leu Leu Ile Thr Leu 
                85                  90                  95


Arg Gly Gln Pro Ala Asn Gln Ser Val Leu Leu Ser Ile Tyr Asp Glu 
            100                 105                 110


Arg Gly Ala Arg Gln Leu Gly Leu Ala Leu Gly Pro Ala Leu Gly Leu 
        115                 120                 125


Leu Gly Asp Pro Phe Arg Pro Leu Pro Gln Gln Val Asn Leu Thr Asp 
    130                 135                 140


Gly Arg Trp His Arg Val Ala Val Ser Ile Asp Gly Glu Met Val Thr 
145                 150                 155                 160


Leu Val Ala Asp Cys Glu Ala Gln Pro Pro Val Leu Gly His Gly Pro 
                165                 170                 175


Arg Phe Ile Ser Ile Ala Gly Leu Thr Val Leu Gly Thr Gln Asp Leu 
            180                 185                 190


Gly Glu Lys Thr Phe Glu Gly Asp Ile Gln Glu Leu Leu Ile Ser Pro 
        195                 200                 205


Asp Pro Gln Ala Ala Phe Gln Ala Cys Glu Arg Tyr Leu Pro Asp Cys 
    210                 215                 220


Asp Asn Leu Ala Pro Ala Ala Thr Val Ala Pro Gln Gly Glu Pro Glu 
225                 230                 235                 240


Thr Pro Arg Pro Arg Arg Lys Gly Lys Gly Lys Gly Arg Lys Lys Gly 
                245                 250                 255


Arg Gly Arg Lys Gly Lys Gly Arg Lys Lys Asn Lys Glu Ile Trp Thr 
            260                 265                 270


Ser Ser Pro Pro Pro Asp Ser Ala Glu Asn Gln Thr Ser Thr Asp Ile 
        275                 280                 285


Pro Lys Thr Glu Thr Pro Ala Pro Asn Leu Pro Pro Thr Pro Thr Pro 
    290                 295                 300


Leu Val Val Thr Ser Thr Val Thr Thr Gly Leu Asn Ala Thr Ile Leu 
305                 310                 315                 320


Glu Arg Ser Leu Asp Pro Asp Ser Gly Thr Glu Leu Gly Thr Leu Glu 
                325                 330                 335


Thr Lys Ala Ala Arg Glu Asp Glu Glu Gly Asp Asp Ser Thr Met Gly 
            340                 345                 350


Pro Asp Phe Arg Ala Ala Glu Tyr Pro Ser Arg Thr Gln Phe Gln Ile 
        355                 360                 365


Phe Pro Gly Ala Gly Glu Lys Gly Ala Lys Gly Glu Pro Ala Val Ile 
    370                 375                 380


Glu Lys Gly Gln Gln Phe Glu Gly Pro Pro Gly Ala Pro Gly Pro Gln 
385                 390                 395                 400


Gly Val Val Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Phe Pro Gly 
                405                 410                 415


Asp Pro Gly Pro Pro Gly Pro Ala Gly Leu Pro Gly Ile Pro Gly Ile 
            420                 425                 430


Asp Gly Ile Arg Gly Pro Pro Gly Thr Val Ile Met Met Pro Phe Gln 
        435                 440                 445


Phe Ala Gly Gly Ser Phe Lys Gly Pro Pro Val Ser Phe Gln Gln Ala 
    450                 455                 460


Gln Ala Gln Ala Val Leu Gln Gln Thr Gln Leu Ser Met Lys Gly Pro 
465                 470                 475                 480


Pro Gly Pro Val Gly Leu Thr Gly Arg Pro Gly Pro Val Gly Leu Pro 
                485                 490                 495


Gly His Pro Gly Leu Lys Gly Glu Glu Gly Ala Glu Gly Pro Gln Gly 
            500                 505                 510


Pro Arg Gly Leu Gln Gly Pro His Gly Pro Pro Gly Arg Val Gly Lys 
        515                 520                 525


Met Gly Arg Pro Gly Ala Asp Gly Ala Arg Gly Leu Pro Gly Asp Thr 
    530                 535                 540


Gly Pro Lys Gly Asp Arg Gly Phe Asp Gly Leu Pro Gly Leu Pro Gly 
545                 550                 555                 560


Glu Lys Gly Gln Arg Gly Asp Phe Gly His Val Gly Gln Pro Gly Pro 
                565                 570                 575


Pro Gly Glu Asp Gly Glu Arg Gly Ala Glu Gly Pro Pro Gly Pro Thr 
            580                 585                 590


Gly Gln Ala Gly Glu Pro Gly Pro Arg Gly Leu Leu Gly Pro Arg Gly 
        595                 600                 605


Ser Pro Gly Pro Thr Gly Arg Pro Gly Val Thr Gly Ile Asp Gly Ala 
    610                 615                 620


Pro Gly Ala Lys Gly Asn Val Gly Pro Pro Gly Glu Pro Gly Pro Pro 
625                 630                 635                 640


Gly Gln Gln Gly Asn His Gly Ser Gln Gly Leu Pro Gly Pro Gln Gly 
                645                 650                 655


Leu Ile Gly Thr Pro Gly Glu Lys Gly Pro Pro Gly Asn Pro Gly Ile 
            660                 665                 670


Pro Gly Leu Pro Gly Ser Asp Gly Pro Leu Gly His Pro Gly His Glu 
        675                 680                 685


Gly Pro Thr Gly Glu Lys Gly Ala Gln Gly Pro Pro Gly Ser Ala Gly 
    690                 695                 700


Pro Pro Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Thr Ser Gly Asn 
705                 710                 715                 720


Arg Gly Leu Gln Gly Glu Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro 
                725                 730                 735


Gly Phe Lys Gly Asp Val Gly Leu Lys Gly Asp Gln Gly Lys Pro Gly 
            740                 745                 750


Ala Pro Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Gln 
        755                 760                 765


Ala Gly Gln Ala Gly Glu Glu Gly Pro Pro Gly Ser Ala Gly Glu Lys 
    770                 775                 780


Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Pro Gly 
785                 790                 795                 800


Pro Lys Gly Ser Ile Gly Phe Pro Gly Pro Leu Gly Pro Ile Gly Glu 
                805                 810                 815


Lys Gly Lys Ser Gly Lys Thr Gly Gln Pro Gly Leu Glu Gly Glu Arg 
            820                 825                 830


Gly Pro Pro Gly Ser Arg Gly Glu Arg Gly Gln Pro Gly Ala Thr Gly 
        835                 840                 845


Gln Pro Gly Pro Lys Gly Asp Val Gly Gln Asp Gly Ala Pro Gly Ile 
    850                 855                 860


Pro Gly Glu Lys Gly Leu Pro Gly Leu Gln Gly Pro Pro Gly Phe Pro 
865                 870                 875                 880


Gly Pro Lys Gly Pro Pro Gly His Gln Gly Lys Asp Gly Arg Pro Gly 
                885                 890                 895


His Pro Gly Gln Arg Gly Glu Leu Gly Phe Gln Gly Gln Thr Gly Pro 
            900                 905                 910


Pro Gly Pro Ala Gly Val Leu Gly Pro Gln Gly Lys Thr Gly Glu Val 
        915                 920                 925


Gly Pro Leu Gly Glu Arg Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
    930                 935                 940


Glu Gln Gly Leu Pro Gly Leu Glu Gly Arg Glu Gly Ala Lys Gly Glu 
945                 950                 955                 960


Leu Gly Pro Pro Gly Pro Leu Gly Lys Glu Gly Pro Ala Gly Leu Arg 
                965                 970                 975


Gly Phe Pro Gly Pro Lys Gly Gly Pro Gly Asp Pro Gly Pro Thr Gly 
            980                 985                 990


Leu Lys Gly Asp Lys Gly Pro Pro Gly Pro Val Gly Ala Asn Gly Ser 
        995                 1000                1005


Pro Gly Glu Arg Gly Pro Leu Gly Pro Ala Gly Gly Ile Gly Leu Pro 
    1010                1015                1020


Gly Gln Ser Gly Ser Glu Gly Pro Val Gly Pro Ala Gly Lys Lys Gly 
1025                1030                1035                1040


Ser Arg Gly Glu Arg Gly Pro Pro Gly Pro Thr Gly Lys Asp Gly Ile 
                1045                1050                1055


Pro Gly Pro Leu Gly Pro Leu Gly Pro Pro Gly Ala Ala Gly Pro Ser 
            1060                1065                1070


Gly Glu Glu Gly Asp Lys Gly Asp Val Gly Ala Pro Gly His Lys Gly 
        1075                1080                1085


Ser Lys Gly Asp Lys Gly Asp Ala Gly Pro Pro Gly Gln Pro Gly Ile 
    1090                1095                1100


Arg Gly Pro Ala Gly His Pro Gly Pro Pro Gly Ala Asp Gly Ala Gln 
1105                1110                1115                1120


Gly Arg Arg Gly Pro Pro Gly Leu Phe Gly Gln Lys Gly Asp Asp Gly 
                1125                1130                1135


Val Arg Gly Phe Val Gly Val Ile Gly Pro Pro Gly Leu Gln Gly Leu 
            1140                1145                1150


Pro Gly Pro Pro Gly Glu Lys Gly Glu Val Gly Asp Val Gly Ser Met 
        1155                1160                1165


Gly Pro His Gly Ala Pro Gly Pro Arg Gly Pro Gln Gly Pro Thr Gly 
    1170                1175                1180


Ser Glu Gly Thr Pro Gly Leu Pro Gly Gly Val Gly Gln Pro Gly Ala 
1185                1190                1195                1200


Val Gly Glu Lys Gly Glu Arg Gly Asp Ala Gly Asp Pro Gly Pro Pro 
                1205                1210                1215


Gly Ala Pro Gly Ile Pro Gly Pro Lys Gly Asp Ile Gly Glu Lys Gly 
            1220                1225                1230


Asp Ser Gly Pro Ser Gly Ala Ala Gly Pro Pro Gly Lys Lys Gly Pro 
        1235                1240                1245


Pro Gly Glu Asp Gly Ala Lys Gly Ser Val Gly Pro Thr Gly Leu Pro 
    1250                1255                1260


Gly Asp Leu Gly Pro Pro Gly Asp Pro Gly Val Ser Gly Ile Asp Gly 
1265                1270                1275                1280


Ser Pro Gly Glu Lys Gly Asp Pro Gly Asp Val Gly Gly Pro Gly Pro 
                1285                1290                1295


Pro Gly Ala Ser Gly Glu Pro Gly Ala Pro Gly Pro Pro Gly Lys Arg 
            1300                1305                1310


Gly Pro Ser Gly His Met Gly Arg Glu Gly Arg Glu Gly Glu Lys Gly 
        1315                1320                1325


Ala Lys Gly Glu Pro Gly Pro Asp Gly Pro Pro Gly Arg Thr Gly Pro 
    1330                1335                1340


Met Gly Ala Arg Gly Pro Pro Gly Arg Val Gly Pro Glu Gly Leu Arg 
1345                1350                1355                1360


Gly Ile Pro Gly Pro Val Gly Glu Pro Gly Leu Leu Gly Ala Pro Gly 
                1365                1370                1375


Gln Met Gly Pro Pro Gly Pro Leu Gly Pro Ser Gly Leu Pro Gly Leu 
            1380                1385                1390


Lys Gly Asp Thr Gly Pro Lys Gly Glu Lys Gly His Ile Gly Leu Ile 
        1395                1400                1405


Gly Leu Ile Gly Pro Pro Gly Glu Ala Gly Glu Lys Gly Asp Gln Gly 
    1410                1415                1420


Leu Pro Gly Val Gln Gly Pro Pro Gly Pro Lys Gly Asp Pro Gly Pro 
1425                1430                1435                1440


Pro Gly Pro Ile Gly Ser Leu Gly His Pro Gly Pro Pro Gly Val Ala 
                1445                1450                1455


Gly Pro Leu Gly Gln Lys Gly Ser Lys Gly Ser Pro Gly Ser Met Gly 
            1460                1465                1470


Pro Arg Gly Asp Thr Gly Pro Ala Gly Pro Pro Gly Pro Pro Gly Ala 
        1475                1480                1485


Pro Ala Glu Leu His Gly Leu Arg Arg Arg Arg Arg Phe Val Pro Val 
    1490                1495                1500


Pro Leu Pro Val Val Glu Gly Gly Leu Glu Glu Val Leu Ala Ser Leu 
1505                1510                1515                1520


Thr Ser Leu Ser Leu Glu Leu Glu Gln Leu Arg Arg Pro Pro Gly Thr 
                1525                1530                1535


Ala Glu Arg Pro Gly Leu Val Cys His Glu Leu His Arg Asn His Pro 
            1540                1545                1550


His Leu Pro Asp Gly Glu Tyr Trp Ile Asp Pro Asn Gln Gly Cys Ala 
        1555                1560                1565


Arg Asp Ser Phe Arg Val Phe Cys Asn Phe Thr Ala Gly Gly Glu Thr 
    1570                1575                1580


Cys Leu Tyr Pro Asp Lys Lys Phe Glu Ile Val Lys Leu Ala Ser Trp 
1585                1590                1595                1600


Ser Lys Glu Lys Pro Gly Gly Trp Tyr Ser Thr Phe Arg Arg Gly Lys 
                1605                1610                1615


Lys Phe Ser Tyr Val Asp Ala Asp Gly Ser Pro Val Asn Val Val Gln 
            1620                1625                1630


Leu Asn Phe Leu Lys Leu Leu Ser Ala Thr Ala Arg Gln Asn Phe Thr 
        1635                1640                1645


Tyr Ser Cys Gln Asn Ala Ala Ala Trp Leu Asp Glu Ala Thr Gly Asp 
    1650                1655                1660


Tyr Ser His Ser Ala Arg Phe Leu Gly Thr Asn Gly Glu Glu Leu Ser 
1665                1670                1675                1680


Phe Asn Gln Thr Thr Ala Ala Thr Val Ser Val Pro Gln Asp Gly Cys 
                1685                1690                1695


Arg Leu Arg Lys Gly Gln Thr Lys Thr Leu Phe Glu Phe Ser Ser Ser 
            1700                1705                1710


Arg Ala Gly Phe Leu Pro Leu Trp Asp Val Ala Ala Thr Asp Phe Gly 
        1715                1720                1725


Gln Thr Asn Gln Lys Phe Gly Phe Glu Leu Gly Pro Val Cys Phe Ser 
    1730                1735                1740


Ser 
1745


<210>  1155
<211>  2674
<212>  DNA
<213>  Homo sapiens

<400>  1155
cgggttcctg agaattgtca atcaggcgcg aggcagagag gagggtgtga cgttccagga     60

gctagtggcc tcttcaccct ggtgacctct gttccgtatt ctgtcactga gagacgccct    120

gggacatctg tggtggcttt tgtcgcgctg ggacctaccc tgactacggg agttgggagg    180

acccgggaca ccgcacagcc gggaaatgga ctcagtggcc tttgaggatg tggctgtgaa    240

cttcacccat gaggagtggg ctttgctggg tccatcacag aagaatctct acagagatgt    300

gatgcgagaa accattagga acctgaactg tataggaatg aaatgggaaa accagaacat    360

tgatgatcag caccaaaatc tcaggagaaa tccaaggtgt gatgtggtag agagatttgg    420

taaaagtaaa gatggtagtc agtgtggaga aaccttaagc cagattcgaa atagtattgt    480

aaacaagaac actcccgcca gagtagatgc atgtggaagc agtgtgaatg gagaagtcat    540

aatgggtcat tcatccctga attgctacat cagagttgat actggacaca aacaccggga    600

gtgtcatgaa tatgcagaga agtcatatac acataagcag tgtgggaaag gcttaagtta    660

tcgccactcc tttcaaacat gtgaaaggcc tcacactgga aagaaaccct atgattgtaa    720

ggaatgtgga aaaaccttca gttctcctgg aaaccttcga agacatatgg tagtaaaagg    780

tggagatgga ccttataaat gtgaattgtg tgggaaagcc tttttttggc ccagtttatt    840

acgtatgcat gaaagaactc acactggaga gaaaccatat gaatgtaagc agtgttctaa    900

agccttccct gtttacagtt cctatctaag acatgaaaaa atacacactg gggagaaacc    960

gtatgaatgt aagcagtgtt ctaaagcctt ccctgattac agttcatatc taagacatga   1020

aagaactcac actggagaga aaccctacaa atgtaaacaa tgtgggaaag ccttcagtgt   1080

ttccggttcc cttcgagtac atgaaagaat tcacactgga gagaaaccct atacatgtaa   1140

acagtgtggg aaagcgtttt gtcatcttgg aagctttcaa agacacatga taatgcacag   1200

tggagatgga cctcataaat gtaagatatg tgggaaaggc tttgattttc ctggttcagc   1260

acgaattcat gaaggaactc acactctaga gaaaccctat gaatgtaagc aatgtgggaa   1320

attgttatct catcgctcaa gctttcgaag acacatgatg gcacacactg gagatggccc   1380

tcataaatgc acagtatgtg ggaaagcctt tgattctcct agtgtatttc aaagacatga   1440

aaggactcac actggagaga aaccctatga atgcaagcaa tgtgggaaag ccttccgtac   1500

ttccagttcc cttcgaaaac atgaaacaac acacactgga gagcaaccct ataaatgtaa   1560

atgtggaaaa gcttttagtg atttattttc ctttcaaagt catgaaacaa cacacagtga   1620

agaggagcct tatgaatgta aggagtgtgg gaaagcattt agttctttta aatacttttg   1680

tcgccatgaa aggactcaca gtgaagaaaa atcttatgag tgtcaaattt gtggcaaagc   1740

cttcagtcgt ttcagttact taaaaactca tgaaaggact cacacggcag agaagccata   1800

tgaatgtaag caatgcagga aagcattctt ttggccctct ttccttctaa gacatgaaag   1860

gactcacact ggagaaagac cctatgaatg taaacactgt ggtaaagcct tcagtcgttc   1920

cagtttctgt cgagaacatg aaagaactca cactggagag aagccctatg aatgtaagga   1980

atgtgggaaa gccttcagtt ctctcagttc ctttaataga cataaaagga cacactggaa   2040

ggatattcta taagtgtatg gaatgtggga aagcattcat tggttttatc acattcagat   2100

acttgaaaga aataaatcct gtgaatgtaa acgtggtaaa gccttaagaa gtttccaggc   2160

tgggcgcagc ggctcacacc tgtaatccca gcactttgag aggccgagga gggcagatca   2220

cgaggccagg agatcgagac cagcctggct aacatgggaa accctgtctc tactaaaaat   2280

acggaaaaaa aaaaaaatag ccaggcatag ttgctcacac ctgtagtcct agctactcag   2340

gaggctgagg caggagaatc ccttgaaccc gggaggtgga ggttgcagtg agccgagatt   2400

gcactactgc actccagctt gggtgctaga gcgagactcc atctcaaaaa aaaaaaaaaa   2460

agtttccatt tctttcaaat agagttgctg cctgctatat gcaagaagat tggttccagt   2520

acaccctgag tatacctaaa tccacagatg ccagctcttt tataaaatgg aatattcgca   2580

tgtacctacc cacattctcc tgtatactct ataaatgtct agattaatta aaatatctca   2640

tgcattgtaa aaaaaaaaaa aaaaaaaaaa aaaa                               2674


<210>  1156
<211>  615
<212>  PRT
<213>  Homo sapiens

<400>  1156

Met Asp Ser Val Ala Phe Glu Asp Val Ala Val Asn Phe Thr His Glu 
1               5                   10                  15


Glu Trp Ala Leu Leu Gly Pro Ser Gln Lys Asn Leu Tyr Arg Asp Val 
            20                  25                  30


Met Arg Glu Thr Ile Arg Asn Leu Asn Cys Ile Gly Met Lys Trp Glu 
        35                  40                  45


Asn Gln Asn Ile Asp Asp Gln His Gln Asn Leu Arg Arg Asn Pro Arg 
    50                  55                  60


Cys Asp Val Val Glu Arg Phe Gly Lys Ser Lys Asp Gly Ser Gln Cys 
65                  70                  75                  80


Gly Glu Thr Leu Ser Gln Ile Arg Asn Ser Ile Val Asn Lys Asn Thr 
                85                  90                  95


Pro Ala Arg Val Asp Ala Cys Gly Ser Ser Val Asn Gly Glu Val Ile 
            100                 105                 110


Met Gly His Ser Ser Leu Asn Cys Tyr Ile Arg Val Asp Thr Gly His 
        115                 120                 125


Lys His Arg Glu Cys His Glu Tyr Ala Glu Lys Ser Tyr Thr His Lys 
    130                 135                 140


Gln Cys Gly Lys Gly Leu Ser Tyr Arg His Ser Phe Gln Thr Cys Glu 
145                 150                 155                 160


Arg Pro His Thr Gly Lys Lys Pro Tyr Asp Cys Lys Glu Cys Gly Lys 
                165                 170                 175


Thr Phe Ser Ser Pro Gly Asn Leu Arg Arg His Met Val Val Lys Gly 
            180                 185                 190


Gly Asp Gly Pro Tyr Lys Cys Glu Leu Cys Gly Lys Ala Phe Phe Trp 
        195                 200                 205


Pro Ser Leu Leu Arg Met His Glu Arg Thr His Thr Gly Glu Lys Pro 
    210                 215                 220


Tyr Glu Cys Lys Gln Cys Ser Lys Ala Phe Pro Val Tyr Ser Ser Tyr 
225                 230                 235                 240


Leu Arg His Glu Lys Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys 
                245                 250                 255


Gln Cys Ser Lys Ala Phe Pro Asp Tyr Ser Ser Tyr Leu Arg His Glu 
            260                 265                 270


Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Gln Cys Gly Lys 
        275                 280                 285


Ala Phe Ser Val Ser Gly Ser Leu Arg Val His Glu Arg Ile His Thr 
    290                 295                 300


Gly Glu Lys Pro Tyr Thr Cys Lys Gln Cys Gly Lys Ala Phe Cys His 
305                 310                 315                 320


Leu Gly Ser Phe Gln Arg His Met Ile Met His Ser Gly Asp Gly Pro 
                325                 330                 335


His Lys Cys Lys Ile Cys Gly Lys Gly Phe Asp Phe Pro Gly Ser Ala 
            340                 345                 350


Arg Ile His Glu Gly Thr His Thr Leu Glu Lys Pro Tyr Glu Cys Lys 
        355                 360                 365


Gln Cys Gly Lys Leu Leu Ser His Arg Ser Ser Phe Arg Arg His Met 
    370                 375                 380


Met Ala His Thr Gly Asp Gly Pro His Lys Cys Thr Val Cys Gly Lys 
385                 390                 395                 400


Ala Phe Asp Ser Pro Ser Val Phe Gln Arg His Glu Arg Thr His Thr 
                405                 410                 415


Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys Ala Phe Arg Thr 
            420                 425                 430


Ser Ser Ser Leu Arg Lys His Glu Thr Thr His Thr Gly Glu Gln Pro 
        435                 440                 445


Tyr Lys Cys Lys Cys Gly Lys Ala Phe Ser Asp Leu Phe Ser Phe Gln 
    450                 455                 460


Ser His Glu Thr Thr His Ser Glu Glu Glu Pro Tyr Glu Cys Lys Glu 
465                 470                 475                 480


Cys Gly Lys Ala Phe Ser Ser Phe Lys Tyr Phe Cys Arg His Glu Arg 
                485                 490                 495


Thr His Ser Glu Glu Lys Ser Tyr Glu Cys Gln Ile Cys Gly Lys Ala 
            500                 505                 510


Phe Ser Arg Phe Ser Tyr Leu Lys Thr His Glu Arg Thr His Thr Ala 
        515                 520                 525


Glu Lys Pro Tyr Glu Cys Lys Gln Cys Arg Lys Ala Phe Phe Trp Pro 
    530                 535                 540


Ser Phe Leu Leu Arg His Glu Arg Thr His Thr Gly Glu Arg Pro Tyr 
545                 550                 555                 560


Glu Cys Lys His Cys Gly Lys Ala Phe Ser Arg Ser Ser Phe Cys Arg 
                565                 570                 575


Glu His Glu Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu 
            580                 585                 590


Cys Gly Lys Ala Phe Ser Ser Leu Ser Ser Phe Asn Arg His Lys Arg 
        595                 600                 605


Thr His Trp Lys Asp Ile Leu 
    610                 615


<210>  1157
<211>  889
<212>  DNA
<213>  Homo sapiens

<400>  1157
atggctgatg acgcaggtgc agcgcggggg tccagaggcc ctggggaccc tgggatgggg     60

aaccgcagtg gcttccgcgg agatttcggc agtggcatcc ggggccgggg ccgcggagct    120

ctgagaggca aggccgagga taagaagtgg atgcccgtta ccaagctggg ctgcctggtc    180

aaggacatga agatctagtc cctggaggag atctatctct tctccctgcc catcaaggaa    240

tctgagatca ttgacttgtt cctgggggcc tctctcaagg acgaggtttt gattacacca    300

gtgcagaagc agacccgtgc cggccagtgc accaggttca aggcgtttgt tgccatcggg    360

gactacaatg gccatgtccg tctgggagtt aagtgctcca aggaggcagc cactgccatc    420

cgcggggcca tcatcctggc caagctctcc actgtcctcg tgcgcagagg ctactggggg    480

aacaagatcg gcaagcccca caccgtccct tgcaaggtga caggccactg cggctctgtg    540

ctggtgcgcc tcatccccgc acccagggac actggcatcg tctcagcgcc tgtgcccaag    600

aagctgctca tgatggctgg tatcagtgac tgatacacct cagcccgggg ctgcactgcc    660

atcctgggca acttcgccaa ggccaccttt gatgtcatct ctaagaccta cagctaccta    720

acccctgacc tctggaagga gactgtattc accaagtctc cctatcagga attcactgac    780

cacctcgtta agacccacac cagagtctct gtgcagagga cccaggctcc agctgtggct    840

acaacatagg gctttcatac aagaaaaata aagtaaatta agcctgaaa                889


<210>  1158
<211>  2755
<212>  DNA
<213>  Homo sapiens

<400>  1158
gccaggttca aagagcccgc ggcgtcttca cgcccctgcg ctcagctcta gactcagtcg     60

ctcgctgaga gacgccctgg aacgtctgtg tagcctcagt cgctgagaga cgccctggaa    120

cgtctgtggc agcctctgtc acagtgggac ccgcactggc agcgggaggc agagggagga    180

ccctggaaca tcccggaagc cgggaaatgg acgcagtggc ctttgaggat gtggctgtga    240

acttcaccca ggaggaatgg gctttgctgg gtccatcaca gaagaattta tacagatatg    300

tgatgcaaga aaccatcagg aacctggact gtataagaat gatatgggaa gaacagaata    360

ctgaagatca gtacaaaaat cctaggagaa atctaagatg tcatatggta gagagattca    420

gtgaaagtaa agacagtagt cagtgtggag aaacatttag cctcattcga gatagtattg    480

tgaacaacag catttgtcct ggagaagatc catgtcaaag cgctgagtgt gaagaagtca    540

taatgggtca tttatccctt aatagccaca tcagagttga ttctggacac aaaccacatg    600

agtatcagga atatggagag aagccacata cacataaaca acgtgggaaa gccttcagtt    660

accatcactc ctttcagtcg cgtggaaggc ctcacactgg aaagaaacgc tatgagtgta    720

aggaatgtgg aaaaaccttc agttctcgta gaaaccttcg aagacacatg gtagtgcaag    780

gtggaaatag accttataaa tgtaagttgt gtgggaaagc ttttttttgg cccagtttat    840

tacgtatgca tgaaagaact cacactggag agaaaccgta tgaatgtaag cagtgttcta    900

aagcctttcc tttttacagt tcctatcgaa gacatgagag aatgcacact ggggagaaac    960

cgtatgaatg taagcagtgt tctaaagcct tgcctgattc cagttcctat ataagacatg   1020

aaagaactca cactggagag aaaccatata catgtaaaca gtgtgggaaa gccttcagtg   1080

tttccagttc ccttcgaaga catgaaacca ctcacagtgc agagaaaccc tatgagtgta   1140

agcaatgcgg gaaaacattt catcatcttg gaagctttca gatacacatg aaaaggcaca   1200

ctggagatcg acctcataaa tgtaagatat gtgggaaagg ctttgatcgt cccagtttag   1260

ttcgatatca tgaacgaatt cacactggag agaaacccta tgaatgcaag cagtgtggga   1320

aaacgttatc tcatagctca agctttcgaa gacacatgat aatgcacact ggaggtggac   1380

ctcataaatg caagatatgt gggaaagctt ttgtttatcc tagtgtatgt caaagacacg   1440

aaaagtctca cagtggagag aaaccctatg aatgcaagca gtgtgggaaa gcgttatctc   1500

atagctcaag ctttcgaaga catatggtaa tgcatacggg agatgggccg aataaatgca   1560

aggtatgtgg gaaagccttt gtttatccca gtgtatgtca aagacatgaa aagactcact   1620

ggagagaaac aatatgaatg taaactatta taaagccttc tatatttcca gttccctttg   1680

atatcatgaa taaacttaca ctggacagaa accctataaa tgtaaatgtg ggaaagcctt   1740

tcataatttt tattcctttc aaaatcatga aatatctcac actggagaga tgctgtatga   1800

tataaggaat gtgggaaagt gttcgatttt ttttttaaca ccattgtcaa cataaaacaa   1860

ctcacagagc agaaaaactc tgtgagtgta aaatatgtag ggaagccttc agtcattttg   1920

gtaacttaaa agtacatgag gctgggcaca gtggctcacg cctgtaatcc cagcacttag   1980

ggtgggcaaa ttgcttgacc tcaggaattt gaggcctgcc tgggcaaaat ggtgaaacca   2040

tgtctctaca aaaaatagaa aaagtagcag gtgtggtggt atgcccctgt agtcccagct   2100

acttgggagg ctgaggtggg aagatctctt gagccgaggg ggtgggggtt gcagtgagcc   2160

aagatgcact gcaccccagc ctgggcgaca gagccagacc ctgtctcaaa aaaaaaaaaa   2220

aagtacatga aaggattcac tctggagaga agtcatatga atgtaagaaa tgtagaaaat   2280

cattgagttc tctcaggtcc ttgcatagac ataaaaggac tcactggaga gatactctat   2340

aaatgtgtga aatgtaggga agtattcttt aatgttattt catttcagat agaaataatt   2400

ctcattggag ataaacgcta tgaatgtaaa cacatagtaa agccttaatt ttaagcctca   2460

gtttctttca aatacagtta tcccctaata tttgaggagc gtggttctac caccccctgg   2520

gcatacataa atcgacacat gccaagtcct tttttaaaaa tgacatattt ggtacaaaat   2580

tacccggatg tgatggcaca tgcctgtaat cccagctact caggaggctg aggcaggata   2640

atcacttgaa tccgggaggc ggaggttgcg gtgagccaag gtcgcgccac tgcactccag   2700

cctgggcagc aagagcaaaa caacctctgt cacacacaca aaaaaaaaaa aaaaa        2755


<210>  1159
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  1159

Met Asp Ala Val Ala Phe Glu Asp Val Ala Val Asn Phe Thr Gln Glu 
1               5                   10                  15


Glu Trp Ala Leu Leu Gly Pro Ser Gln Lys Asn Leu Tyr Arg Tyr Val 
            20                  25                  30


Met Gln Glu Thr Ile Arg Asn Leu Asp Cys Ile Arg Met Ile Trp Glu 
        35                  40                  45


Glu Gln Asn Thr Glu Asp Gln Tyr Lys Asn Pro Arg Arg Asn Leu Arg 
    50                  55                  60


Cys His Met Val Glu Arg Phe Ser Glu Ser Lys Asp Ser Ser Gln Cys 
65                  70                  75                  80


Gly Glu Thr Phe Ser Leu Ile Arg Asp Ser Ile Val Asn Asn Ser Ile 
                85                  90                  95


Cys Pro Gly Glu Asp Pro Cys Gln Ser Ala Glu Cys Glu Glu Val Ile 
            100                 105                 110


Met Gly His Leu Ser Leu Asn Ser His Ile Arg Val Asp Ser Gly His 
        115                 120                 125


Lys Pro His Glu Tyr Gln Glu Tyr Gly Glu Lys Pro His Thr His Lys 
    130                 135                 140


Gln Arg Gly Lys Ala Phe Ser Tyr His His Ser Phe Gln Ser Arg Gly 
145                 150                 155                 160


Arg Pro His Thr Gly Lys Lys Arg Tyr Glu Cys Lys Glu Cys Gly Lys 
                165                 170                 175


Thr Phe Ser Ser Arg Arg Asn Leu Arg Arg His Met Val Val Gln Gly 
            180                 185                 190


Gly Asn Arg Pro Tyr Lys Cys Lys Leu Cys Gly Lys Ala Phe Phe Trp 
        195                 200                 205


Pro Ser Leu Leu Arg Met His Glu Arg Thr His Thr Gly Glu Lys Pro 
    210                 215                 220


Tyr Glu Cys Lys Gln Cys Ser Lys Ala Phe Pro Phe Tyr Ser Ser Tyr 
225                 230                 235                 240


Arg Arg His Glu Arg Met His Thr Gly Glu Lys Pro Tyr Glu Cys Lys 
                245                 250                 255


Gln Cys Ser Lys Ala Leu Pro Asp Ser Ser Ser Tyr Ile Arg His Glu 
            260                 265                 270


Arg Thr His Thr Gly Glu Lys Pro Tyr Thr Cys Lys Gln Cys Gly Lys 
        275                 280                 285


Ala Phe Ser Val Ser Ser Ser Leu Arg Arg His Glu Thr Thr His Ser 
    290                 295                 300


Ala Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys Thr Phe His His 
305                 310                 315                 320


Leu Gly Ser Phe Gln Ile His Met Lys Arg His Thr Gly Asp Arg Pro 
                325                 330                 335


His Lys Cys Lys Ile Cys Gly Lys Gly Phe Asp Arg Pro Ser Leu Val 
            340                 345                 350


Arg Tyr His Glu Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys 
        355                 360                 365


Gln Cys Gly Lys Thr Leu Ser His Ser Ser Ser Phe Arg Arg His Met 
    370                 375                 380


Ile Met His Thr Gly Gly Gly Pro His Lys Cys Lys Ile Cys Gly Lys 
385                 390                 395                 400


Ala Phe Val Tyr Pro Ser Val Cys Gln Arg His Glu Lys Ser His Ser 
                405                 410                 415


Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys Ala Leu Ser His 
            420                 425                 430


Ser Ser Ser Phe Arg Arg His Met Val Met His Thr Gly Asp Gly Pro 
        435                 440                 445


Asn Lys Cys Lys Val Cys Gly Lys Ala Phe Val Tyr Pro Ser Val Cys 
    450                 455                 460


Gln Arg His Glu Lys Thr His Trp Arg Glu Thr Ile 
465                 470                 475


<210>  1160
<211>  1990
<212>  DNA
<213>  Homo sapiens

<400>  1160
ttaaatttgg cagtgattta ttggatacga catttaaggc acagacaacc aataaaagat     60

aaactggact acatcgaaat taaaaacttt tgcgcaccaa aggacaatct caagatgaaa    120

agaaaaccta cagaaaggga gaacacatct gcatatcaca tatcaaataa gggcttaata    180

cccacagtgt ataaagaatt cctacaactc tcttccaagc acttgggagc tgaaaaaaga    240

aagaaatttt ctaaatatta aaaactaaaa attttaaata agaattccta taactcaaca    300

acaaaacaca aatgactcaa ttttaatgag caaaggattt taaaacaaac tggttcaaaa    360

aatatataaa caaccaacaa aaacaaaaac caatgtgcat tattattggt cattagggaa    420

atgcaaatca aaaccacaat gaaaaagcag tacagaacca ttaattggct attatgaaaa    480

aaatacgaca accagtatat gtgacaatgt ggaaaataga aacccttatg cattgctgga    540

gagaatgtaa aacattgtag ccactttgta aagcaatata cctgttcctg aaaaaggttt    600

acaccaatta ttctgtgaac cagcaattac actcctaggg atacatatat ccaaaagaat    660

tgaaagcagg gactcacaca gacatagaca taccacatcc acagcagcct tattgatagc    720

agtcaaatta ttactgtgga aacaacccat gtttatcaac ataaaaatgg ataaacaaag    780

tatgctttaa ccatacagtg gaaatttatt cagacacaaa aacaatgagt tcctgataca    840

tgctaccaca tggataaacc ttgaaaacgt tctaagtgaa ataagccaga catggaagga    900

cacatgcata cttccacata tctctctctc tatgaatagt caaattcaca gacagagaaa    960

gtagaatgga gattttcagt actttgggat aggatggaat aggtaattac atgtatggaa   1020

cactaagtag atagagcaag tagcacagta acacgtataa aatgatccct tcctttgtgt   1080

attctagttt gtaccagcac tgtaagaggc ttccagatga gcagttccag tggttaatgt   1140

tggtagttca aagggtaaca ctgccctcta ggcaacatcg tggaggtcta tttgagatat   1200

atttcactac aagttattct catgaatact tcaatgaaac agctcttatc aaggccccca   1260

gtgaccaaat acttgccaaa atctacagtc aacccttttt ccttgtctta ttcaaattct   1320

cagtgacctg tgacacagct gaccactctc cccatattga aataccttct tctggaggct   1380

tccaggagaa gaaacccatg ttttcctcct actacttcat tgggtgttgg aaaccattat   1440

ggagtgagga agtcaatgat ttcaggagct tctccactat tgatgaagta tcaggaatat   1500

ctcaaatgct gcaagggagg ttggtgggga aaacaatcta tgacatgctt gaagacttta   1560

ttgaggaaca cattgacagg acaagagcac cgccatcttt ataacactcc accatcctaa   1620

gctttaagtt tctatttggc cacctggcca aaactgaaaa tgtcagcccc gcccataact   1680

tcaacagaga ataacggccc taactgtaac agaacagcca ggacttcccc aacccctccc   1740

taacagaatt ttgtttcaaa gcacacttct ccactgggcc ctttaaaaaa gcctcaggct   1800

gtaagagaag tttgcacctg accctgccgc tggaagccct tctcaggttt actcccaata   1860

aaactgtctc aactgttgag ccaccttctc atctctcctt tccttaatct ttctatccca   1920

acacaaataa gagagcataa atactaacaa ggaactcgaa gatatactga aattctctgc   1980

agataatgat                                                          1990


<210>  1161
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  1161

Met Ile Pro Ser Phe Val Tyr Ser Ser Leu Tyr Gln His Cys Lys Arg 
1               5                   10                  15


Leu Pro Asp Glu Gln Phe Gln Trp Leu Met Leu Val Val Gln Arg Val 
            20                  25                  30


Thr Leu Pro Ser Arg Gln His Arg Gly Gly Leu Phe Glu Ile Tyr Phe 
        35                  40                  45


Thr Thr Ser Tyr Ser His Glu Tyr Phe Asn Glu Thr Ala Leu Ile Lys 
    50                  55                  60


Ala Pro Ser Asp Gln Ile Leu Ala Lys Ile Tyr Ser Gln Pro Phe Phe 
65                  70                  75                  80


Leu Val Leu Phe Lys Phe Ser Val Thr Cys Asp Thr Ala Asp His Ser 
                85                  90                  95


Pro His Ile Glu Ile Pro Ser Ser Gly Gly Phe Gln Glu Lys Lys Pro 
            100                 105                 110


Met Phe Ser Ser Tyr Tyr Phe Ile Gly Cys Trp Lys Pro Leu Trp Ser 
        115                 120                 125


Glu Glu Val Asn Asp Phe Arg Ser Phe Ser Thr Ile Asp Glu Val Ser 
    130                 135                 140


Gly Ile Ser Gln Met Leu Gln Gly Arg Leu Val Gly Lys Thr Ile Tyr 
145                 150                 155                 160


Asp Met Leu Glu Asp Phe Ile Glu Glu His Ile Asp Arg Thr Arg Ala 
                165                 170                 175


Pro Pro Ser Leu 
            180


<210>  1162
<211>  2825
<212>  DNA
<213>  Homo sapiens

<400>  1162
gctcccgctc ctggctctgt agctgagaga agccctggca ggtcagtggc aggcactgtc     60

acgctgagtc ctatgctggc agcggggaac cttggggaga acacgggaca ccgcggaagc    120

cgggaaatga ttgtgcggct gtaaccggca caggttcgcg gtccgagtca ctgcaccgag    180

actccaaggc ctgcagcaga aacagtttaa tagggggaga ggagagaaga ccccagttcc    240

gcctccatga gaggtttggg gatgggggtg tttaggggtc tggacagggg cggctgaagt    300

gtggggtcgc tggttggtgg ggaagtgaca ggcgaatcct gggacgggag gtgaagaaac    360

cgcattctcc tgctgagtgg gttccctcgt ggggttttca ccctgcttgg cgccagcctt    420

tccgttggaa ttcaagatct gagaaagaac ttgggcaact cgagcagctc tccgagatct    480

tatccccagg cacaatgcag aagccggcgg tcagtgtctt ctgtgacctg actctcagga    540

aggcggcccc cgcgaggcag tggggctcag gtttccattc cttggggaca cacggctggt    600

cagccagttg aatgattgta tttgggggag aagacagaag tgatctcttc cttcctgact    660

ctcagactaa tgaagagaga aaacaatatg attcagtagc ctttgaggat gtggcggtga    720

acttcaccca ggaagagtgg gctttgctgg gtccatcaca gaagagtctg tacagagatg    780

tgatgtggga aaccattagg aacctggact gtataggaat gaaatgggaa gacacaaaca    840

ttgaagatca gcacagaaat cccaggagga gcctaagatg tcatatcata gagagattta    900

gtgaaagtcg ccagccagat agtactgtga atgaaaaacc tcctggagta gatccatgta    960

aaagcagtgt gtgtggagaa atcatgggtt gttcattcct taattgctat atcacatttg   1020

atgctggaca caaaccagat gagtgtcagg aatatggaga gaagccacat acacataaac   1080

aatgtgggac agccttcaat tatcaccact cctttcaaac acaggaaaga cctcacactg   1140

gaaagaaacg ctatgattgt aaggaatgtg ggaaaacctt cagttcttcg ggaaaccttc   1200

gaagacacat aatagtacaa cgtggaggtg gaccttatat atgtaagttg tgtgggaaag   1260

cctttttttg gcctagttta tttcgtatgc atgaaagaac tcacactgga gagaaaccgt   1320

atgaatgtaa gcagtgttgt aaagccttcc ctatttacag ttcctatcta agacatgaaa   1380

gaacacacac tggggagaaa ccatatgaat gcaagcactg ttccaaagcc ttccctgatt   1440

acagttccta tgtaagacat gaaagaactc acactggaga aaaaccctat aaatgtaaac   1500

gatgtggaag agccttcagt gtttccagtt cccttcgaat acatgaaaga actcacactg   1560

gagagaaacc ctatgaatgc aagcaatgcg ggaaagcatt tcatcatctg ggaagctttc   1620

aaagacacat gataaggcac actggagatg gacctcataa atgtaagata tgtgggaaag   1680

gctttgattg tcctagttca ctgcaaagtc atgaaagaac tcacactgga gagaaaccct   1740

atgaatgcaa gcagtgtggg aaagcgttat ctcatcactc aagctttcga agtcatatga   1800

taatgcacac tggagatgga cctcacaaat gcaaggtatg tgggaaagcc ttcatttatc   1860

ccagtgtatt tcaaggacat gaaaggactc atactggtga gaaaccctat gaatgtaaag   1920

aatgtggtaa agccttccgt atttctagtt cccttcgaag acatgaaaca actcacactg   1980

gagagaaacc ctataaatgt aaatgtggga aagcctttat tgatttctat tcctttcaaa   2040

atcatgaaac aactcacact ggagagaagc catatgagtg taaggaatgt gggaaagcat   2100

tcagttgttt cacatacctt tctcaacata gaaggactca catggctgaa aaaccttatg   2160

aatgtaaaac atgtaagaaa gccttcagtc attttggtaa cttaaaagtc catgaaagga   2220

ttcacactgg agagaagcca tatgaatgta aggaatgcag gaaagcattc tcttggctca   2280

cttgccttct gcgacatgaa agaattcaca ctggaaagaa atcttatgaa tgtcaacaat   2340

gtggtaaagc cttcactcgt tctcgtttcc ttcgaggaca tgaaaaaact cacactggag   2400

agaagatgca tgaatgtaag gaatgtggga aggcactgag ttctctcagt tccttgcata   2460

gacataaaag gactcactgg agagatactc tataaatgtg gaaaagcatt cattaatttt   2520

atttcatttc agaaacgtga aagaaatcac ataggagata agcctcatga atgcaaacac   2580

atggtaaagc cttaagatgt ttcttttgaa tatggttatc ccctaaccat atgcagggga   2640

ttggttccag accccctaag catacctaaa tccacagatg ctgtgttcct tttataaaag   2700

gacatttgca tgtaacctat ccacatcctc ctgcatccca taaatcatgc ctagattact   2760

taatttttca ccaacccaaa gcttttgtaa aagtaaaaat aaaaagtagg ttactaaaat   2820

acctc                                                               2825


<210>  1163
<211>  627
<212>  PRT
<213>  Homo sapiens

<400>  1163

Met Ile Val Phe Gly Gly Glu Asp Arg Ser Asp Leu Phe Leu Pro Asp 
1               5                   10                  15


Ser Gln Thr Asn Glu Glu Arg Lys Gln Tyr Asp Ser Val Ala Phe Glu 
            20                  25                  30


Asp Val Ala Val Asn Phe Thr Gln Glu Glu Trp Ala Leu Leu Gly Pro 
        35                  40                  45


Ser Gln Lys Ser Leu Tyr Arg Asp Val Met Trp Glu Thr Ile Arg Asn 
    50                  55                  60


Leu Asp Cys Ile Gly Met Lys Trp Glu Asp Thr Asn Ile Glu Asp Gln 
65                  70                  75                  80


His Arg Asn Pro Arg Arg Ser Leu Arg Cys His Ile Ile Glu Arg Phe 
                85                  90                  95


Ser Glu Ser Arg Gln Pro Asp Ser Thr Val Asn Glu Lys Pro Pro Gly 
            100                 105                 110


Val Asp Pro Cys Lys Ser Ser Val Cys Gly Glu Ile Met Gly Cys Ser 
        115                 120                 125


Phe Leu Asn Cys Tyr Ile Thr Phe Asp Ala Gly His Lys Pro Asp Glu 
    130                 135                 140


Cys Gln Glu Tyr Gly Glu Lys Pro His Thr His Lys Gln Cys Gly Thr 
145                 150                 155                 160


Ala Phe Asn Tyr His His Ser Phe Gln Thr Gln Glu Arg Pro His Thr 
                165                 170                 175


Gly Lys Lys Arg Tyr Asp Cys Lys Glu Cys Gly Lys Thr Phe Ser Ser 
            180                 185                 190


Ser Gly Asn Leu Arg Arg His Ile Ile Val Gln Arg Gly Gly Gly Pro 
        195                 200                 205


Tyr Ile Cys Lys Leu Cys Gly Lys Ala Phe Phe Trp Pro Ser Leu Phe 
    210                 215                 220


Arg Met His Glu Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys 
225                 230                 235                 240


Gln Cys Cys Lys Ala Phe Pro Ile Tyr Ser Ser Tyr Leu Arg His Glu 
                245                 250                 255


Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys His Cys Ser Lys 
            260                 265                 270


Ala Phe Pro Asp Tyr Ser Ser Tyr Val Arg His Glu Arg Thr His Thr 
        275                 280                 285


Gly Glu Lys Pro Tyr Lys Cys Lys Arg Cys Gly Arg Ala Phe Ser Val 
    290                 295                 300


Ser Ser Ser Leu Arg Ile His Glu Arg Thr His Thr Gly Glu Lys Pro 
305                 310                 315                 320


Tyr Glu Cys Lys Gln Cys Gly Lys Ala Phe His His Leu Gly Ser Phe 
                325                 330                 335


Gln Arg His Met Ile Arg His Thr Gly Asp Gly Pro His Lys Cys Lys 
            340                 345                 350


Ile Cys Gly Lys Gly Phe Asp Cys Pro Ser Ser Leu Gln Ser His Glu 
        355                 360                 365


Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys 
    370                 375                 380


Ala Leu Ser His His Ser Ser Phe Arg Ser His Met Ile Met His Thr 
385                 390                 395                 400


Gly Asp Gly Pro His Lys Cys Lys Val Cys Gly Lys Ala Phe Ile Tyr 
                405                 410                 415


Pro Ser Val Phe Gln Gly His Glu Arg Thr His Thr Gly Glu Lys Pro 
            420                 425                 430


Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Arg Ile Ser Ser Ser Leu 
        435                 440                 445


Arg Arg His Glu Thr Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Lys 
    450                 455                 460


Cys Gly Lys Ala Phe Ile Asp Phe Tyr Ser Phe Gln Asn His Glu Thr 
465                 470                 475                 480


Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala 
                485                 490                 495


Phe Ser Cys Phe Thr Tyr Leu Ser Gln His Arg Arg Thr His Met Ala 
            500                 505                 510


Glu Lys Pro Tyr Glu Cys Lys Thr Cys Lys Lys Ala Phe Ser His Phe 
        515                 520                 525


Gly Asn Leu Lys Val His Glu Arg Ile His Thr Gly Glu Lys Pro Tyr 
    530                 535                 540


Glu Cys Lys Glu Cys Arg Lys Ala Phe Ser Trp Leu Thr Cys Leu Leu 
545                 550                 555                 560


Arg His Glu Arg Ile His Thr Gly Lys Lys Ser Tyr Glu Cys Gln Gln 
                565                 570                 575


Cys Gly Lys Ala Phe Thr Arg Ser Arg Phe Leu Arg Gly His Glu Lys 
            580                 585                 590


Thr His Thr Gly Glu Lys Met His Glu Cys Lys Glu Cys Gly Lys Ala 
        595                 600                 605


Leu Ser Ser Leu Ser Ser Leu His Arg His Lys Arg Thr His Trp Arg 
    610                 615                 620


Asp Thr Leu 
625


<210>  1164
<211>  2635
<212>  DNA
<213>  Homo sapiens

<400>  1164
cgtccgctgg aagttctgag gcagcctttg tctggctgga acacgcattg gcagcgggag     60

ctgtcggtag gacctgggac accgcggaag tcgggaaatg gcctcagtgg ctttagagga    120

tgtggctgtg aacttcaccc gagaagagtg ggctttgctg ggtccttgtc agaagaatct    180

ctacaaagat gtgatgcagg aaaccatcag gaacctggat tgtgtagtaa tgaaatggaa    240

agaccagaac attgaagatc aatatagata tcccaggaaa aatctaagat gtcgtatgtt    300

agagagattt attgaaagta aagatggaac tcaatgtgga gaaacatcta gccagattca    360

agatagtatt gtgaccaaga acactcttcc tggagtaggt ccttgtgaaa gcagtatgag    420

aggagaaaaa gtcatgggtc attcatccct taattgttac atcagagttg gtgctgggca    480

caaaccacat gagtatcatg aatgtggaga gaagccagat acgcataaac aacgtgggaa    540

agccttcagt taccacaact catttcaaac acatgagagg cttcacactg gaaagaaacc    600

atatgattgt aaagaatgtg ggaagtcctt cagttctttg ggaaaccttc aaagacacat    660

ggcagtgcag cgtggagatg gaccttataa atgtaagttg tgtgggaaag cgtttttttg    720

gcccagttta ttacatatgc atgaaagaac gcacactgga gagaaaccat atgaatgtaa    780

gcagtgttct aaagcctttt ctttttacag ttcctatcta agacatgaaa gaacacatac    840

tggggagaaa ccgtatgaat gtaaacagtg ttctaaagcc tttccttttt acagttccta    900

tctaagacat gaaagaacac atactgggga gaaaccatat aaatgtaagc agtgttctaa    960

agccttccct gattccagtt cttgtctaat acatgaaaga actcacactg gagagaaacc   1020

ctatacatgt aaacaatgtg ggaaagcctt cagtgtttcc ggttcccttc aaagacatga   1080

aaccactcac agtgcagaga aaccctatgc atgtcagcaa tgtgggaaag cgtttcatca   1140

tctgggaagc tttcaaagac acatgataag gcacactgga aatggacctc ataaatgtaa   1200

gatatgtggg aaaggctttg attgtcctag ttcactgcaa agtcatgaaa gaactcacac   1260

tggagagaaa ccctatgaat gcaagcagtg tgggaaagca ttatctcatc gctcaagctt   1320

tcgaagtcat atgataatgc acactggaga tggacctcat aaatgcaagg tatgtgggaa   1380

agcctttgtt tatcccagtg tatttcaaag acatgaaagg actcacactg cagagaaacc   1440

ctataaatgt aaacaatgtg gcaaagccta ccgtatttcc agttcccttc gaaggcatga   1500

aacaactcat actggagaga aaccctataa atgcacactt gggaaagcct ttattgattt   1560

ctgttccttt caaaatcaca aaacaactca cactggagag aagccatatg agtgtaagga   1620

atgtgggaaa gcattcagtc gtttcagata cctttctcga cataaaagga ctcacacagg   1680

agagaaacct tatgagtgta aaacatgtag gaaagccttc ggtcattatg ataacttaaa   1740

ggtacatgaa agaattcact ctggagagaa gccgtatgaa tgtaaggaat gtgggaaagc   1800

attctcttgg ctcacttgct ttctacgaca tgaaagaatt cacatgagag agaaatccta   1860

tgaatgtcca caatgtggta aagccttcac tcattcccgt tttcttcaag gacatgaaaa   1920

aactcatact ggagagaacc cgtatgaatg taaggaatgt gggaaagcat ttgcttctct   1980

cagttccttg catagacata aaaagactca ctggaaaaaa actcacactg gagagaaccc   2040

atatgaatgt aaggaatgtg ggaaagcatt tgcttctctc agttccttgc atagacataa   2100

aaagactcac tagcattctc tctaaatgta tggaatgtgg gaaagcattt attaatttta   2160

tttcatttca gatacttgta cgaaacacat tggagataga ccctgtgaat gtaagcactt   2220

ggtaaagcct taagtagttt cagtttcttt ccagtacagt catcccttga tacctgctgg   2280

gtattggttc cagcactctg tgagccatgt ccagtccctt ttataaaatg acatgtttgt   2340

atgtaactta cccacatcct cttgtatagt ctcaattatg tctagattac ttaaaatacc   2400

tcatgcatta taaaagctat gcaaatagtt gttctattgt attgtttagg gactcatgat   2460

aaggaaaaga gtctatgtat tttcagtata gatgcagtaa ttgtcagcct atcaacatag   2520

tgtagtcagc cagaacatta aagtttcttt gtttcaactc tcaaaaaaaa aaaaaaaaaa   2580

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa        2635


<210>  1165
<211>  671
<212>  PRT
<213>  Homo sapiens

<400>  1165

Met Ala Ser Val Ala Leu Glu Asp Val Ala Val Asn Phe Thr Arg Glu 
1               5                   10                  15


Glu Trp Ala Leu Leu Gly Pro Cys Gln Lys Asn Leu Tyr Lys Asp Val 
            20                  25                  30


Met Gln Glu Thr Ile Arg Asn Leu Asp Cys Val Val Met Lys Trp Lys 
        35                  40                  45


Asp Gln Asn Ile Glu Asp Gln Tyr Arg Tyr Pro Arg Lys Asn Leu Arg 
    50                  55                  60


Cys Arg Met Leu Glu Arg Phe Ile Glu Ser Lys Asp Gly Thr Gln Cys 
65                  70                  75                  80


Gly Glu Thr Ser Ser Gln Ile Gln Asp Ser Ile Val Thr Lys Asn Thr 
                85                  90                  95


Leu Pro Gly Val Gly Pro Cys Glu Ser Ser Met Arg Gly Glu Lys Val 
            100                 105                 110


Met Gly His Ser Ser Leu Asn Cys Tyr Ile Arg Val Gly Ala Gly His 
        115                 120                 125


Lys Pro His Glu Tyr His Glu Cys Gly Glu Lys Pro Asp Thr His Lys 
    130                 135                 140


Gln Arg Gly Lys Ala Phe Ser Tyr His Asn Ser Phe Gln Thr His Glu 
145                 150                 155                 160


Arg Leu His Thr Gly Lys Lys Pro Tyr Asp Cys Lys Glu Cys Gly Lys 
                165                 170                 175


Ser Phe Ser Ser Leu Gly Asn Leu Gln Arg His Met Ala Val Gln Arg 
            180                 185                 190


Gly Asp Gly Pro Tyr Lys Cys Lys Leu Cys Gly Lys Ala Phe Phe Trp 
        195                 200                 205


Pro Ser Leu Leu His Met His Glu Arg Thr His Thr Gly Glu Lys Pro 
    210                 215                 220


Tyr Glu Cys Lys Gln Cys Ser Lys Ala Phe Ser Phe Tyr Ser Ser Tyr 
225                 230                 235                 240


Leu Arg His Glu Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys 
                245                 250                 255


Gln Cys Ser Lys Ala Phe Pro Phe Tyr Ser Ser Tyr Leu Arg His Glu 
            260                 265                 270


Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Gln Cys Ser Lys 
        275                 280                 285


Ala Phe Pro Asp Ser Ser Ser Cys Leu Ile His Glu Arg Thr His Thr 
    290                 295                 300


Gly Glu Lys Pro Tyr Thr Cys Lys Gln Cys Gly Lys Ala Phe Ser Val 
305                 310                 315                 320


Ser Gly Ser Leu Gln Arg His Glu Thr Thr His Ser Ala Glu Lys Pro 
                325                 330                 335


Tyr Ala Cys Gln Gln Cys Gly Lys Ala Phe His His Leu Gly Ser Phe 
            340                 345                 350


Gln Arg His Met Ile Arg His Thr Gly Asn Gly Pro His Lys Cys Lys 
        355                 360                 365


Ile Cys Gly Lys Gly Phe Asp Cys Pro Ser Ser Leu Gln Ser His Glu 
    370                 375                 380


Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys 
385                 390                 395                 400


Ala Leu Ser His Arg Ser Ser Phe Arg Ser His Met Ile Met His Thr 
                405                 410                 415


Gly Asp Gly Pro His Lys Cys Lys Val Cys Gly Lys Ala Phe Val Tyr 
            420                 425                 430


Pro Ser Val Phe Gln Arg His Glu Arg Thr His Thr Ala Glu Lys Pro 
        435                 440                 445


Tyr Lys Cys Lys Gln Cys Gly Lys Ala Tyr Arg Ile Ser Ser Ser Leu 
    450                 455                 460


Arg Arg His Glu Thr Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Thr 
465                 470                 475                 480


Leu Gly Lys Ala Phe Ile Asp Phe Cys Ser Phe Gln Asn His Lys Thr 
                485                 490                 495


Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala 
            500                 505                 510


Phe Ser Arg Phe Arg Tyr Leu Ser Arg His Lys Arg Thr His Thr Gly 
        515                 520                 525


Glu Lys Pro Tyr Glu Cys Lys Thr Cys Arg Lys Ala Phe Gly His Tyr 
    530                 535                 540


Asp Asn Leu Lys Val His Glu Arg Ile His Ser Gly Glu Lys Pro Tyr 
545                 550                 555                 560


Glu Cys Lys Glu Cys Gly Lys Ala Phe Ser Trp Leu Thr Cys Phe Leu 
                565                 570                 575


Arg His Glu Arg Ile His Met Arg Glu Lys Ser Tyr Glu Cys Pro Gln 
            580                 585                 590


Cys Gly Lys Ala Phe Thr His Ser Arg Phe Leu Gln Gly His Glu Lys 
        595                 600                 605


Thr His Thr Gly Glu Asn Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala 
    610                 615                 620


Phe Ala Ser Leu Ser Ser Leu His Arg His Lys Lys Thr His Trp Lys 
625                 630                 635                 640


Lys Thr His Thr Gly Glu Asn Pro Tyr Glu Cys Lys Glu Cys Gly Lys 
                645                 650                 655


Ala Phe Ala Ser Leu Ser Ser Leu His Arg His Lys Lys Thr His 
            660                 665                 670


<210>  1166
<211>  2154
<212>  DNA
<213>  Homo sapiens

<400>  1166
gcgcaaacgg cgagggcgtg gctaccagcc gctgcgctcc gctctggggt ctcctcaccc     60

cagaaggccc tcaggtggag gaagggcctc aggtggaggt aggacctgtg ctggccgcgg    120

gagaggtaaa cagaacacca ggacatccca gagtctggga aatggactca gtggtctttg    180

aggatgtggc tgtgaacttc acccaggagg agtgggcttt gctgggtccc tctcagaaga    240

aactctacag agatgtgatg caagaaacct ttgttaactt ggcctctata ggggaaaact    300

gggaggagaa gaacattgaa gatcacaaaa atcaggggag aaagctaaga agtcatatgg    360

tagagaggct ctgtgaaagg aaagaaggta gtcagtttgg agaaaccatc agtcagactc    420

caaatcctaa accaaacaag aaaactttta ctagagtaaa accatatgaa tgtagtgtgt    480

gtggaaagga ctatatgtgt cattcatctc ttaataggca catgagatct catactgaac    540

atagatcata tgaatatcac aaatatggag agaaatcata tgaatgtaag gaatgtggga    600

aaagattcag ctttcgaagt tcatttcgaa tacatgaaag aactcacact ggagagaaac    660

cctataaatg taaacagtgt ggtaaggctt tcagttggcc cagttccttt caaatacatg    720

aaagaactca tactggagag aaaccttatg aatgtaagga atgtgggaag gccttcattt    780

atcacacaac ctttcgagga cacatgagaa tgcacacagg ggagaaaccc tataaatgta    840

aagaatgcgg gaaaacgttc agtcatccca gttcttttcg aaatcatgaa agaactcact    900

ctggagagaa accctatgaa tgtaaacaat gtggaaaagc tttcagatat taccaaactt    960

ttcaaataca tgaaaggact cacactgggg aaaaacccta tcagtgtaag caatgtggta   1020

aagctcttag ttgtcccaca tcctttcgaa gtcatgaaag gattcacact ggagaaaaac   1080

cctataaatg taaaaaatgt gggaaagcct tcagttttcc tagttccttt agaaaacatg   1140

aaagaattca tacaggagag aaaccctatg attgtaagga atgtgggaaa gcattcattt   1200

ctcttccaag ctatcgaaga catatgataa tgcacactgg aaatggacct tataaatgca   1260

aggaatgtgg gaaagccttt gattgtccta gttcttttca aatccatgaa cgaactcaca   1320

ctggagagaa accctatgaa tgtaaacagt gtggtaaagc cttcagttgt tccagttcct   1380

ttcgaatgca tgaaagaact cacactggag agaaacccca tgaatgtaaa caatgtggta   1440

aagccttcag ttgttccagt tctgttcgaa tacatgaaag gactcacact ggagagaaac   1500

cctatgaatg taaacagtgt ggtaaagcct tcagttgttc cagttccttt cgaatgcatg   1560

aaagaattca cactggagag aaaccctatg aatgtaaaca gtgtggtaaa gcctttagtt   1620

tttctagttc ctttcggatg catgaaagga ctcacactgg agagaaaccc tatgaatgta   1680

aacaatgtgg taaagccttc agttgttcca gttcctttcg aatgcatgaa aggactcaca   1740

ctggggagaa accctatgaa tgtaaacagt gtggtaaggc gtttagttgt tccagttcca   1800

ttcgaataca tgaaaggact cacactggag agaaacctta tgagtgtaaa caatgtggta   1860

aggccttcag ttgttctagt tctgttcgaa tgcatgaaag gactcacact ggagtgaaac   1920

cctatgaatg taaacaatgt gacaaagcct tcagttgctc acgttccttt cgaatccatg   1980

aacgaactca cactggagag aaaccctatg catgtcaaca atgtggtaaa gccttcaagt   2040

gttcccgttc ctttcgaata catgaaagag ttcatagtgg agagtaaccc tatgtatata   2100

agcaatatgg caaagttttc agttgtccta tttccttttt tttttttttt tttt         2154


<210>  1167
<211>  641
<212>  PRT
<213>  Homo sapiens

<400>  1167

Met Asp Ser Val Val Phe Glu Asp Val Ala Val Asn Phe Thr Gln Glu 
1               5                   10                  15


Glu Trp Ala Leu Leu Gly Pro Ser Gln Lys Lys Leu Tyr Arg Asp Val 
            20                  25                  30


Met Gln Glu Thr Phe Val Asn Leu Ala Ser Ile Gly Glu Asn Trp Glu 
        35                  40                  45


Glu Lys Asn Ile Glu Asp His Lys Asn Gln Gly Arg Lys Leu Arg Ser 
    50                  55                  60


His Met Val Glu Arg Leu Cys Glu Arg Lys Glu Gly Ser Gln Phe Gly 
65                  70                  75                  80


Glu Thr Ile Ser Gln Thr Pro Asn Pro Lys Pro Asn Lys Lys Thr Phe 
                85                  90                  95


Thr Arg Val Lys Pro Tyr Glu Cys Ser Val Cys Gly Lys Asp Tyr Met 
            100                 105                 110


Cys His Ser Ser Leu Asn Arg His Met Arg Ser His Thr Glu His Arg 
        115                 120                 125


Ser Tyr Glu Tyr His Lys Tyr Gly Glu Lys Ser Tyr Glu Cys Lys Glu 
    130                 135                 140


Cys Gly Lys Arg Phe Ser Phe Arg Ser Ser Phe Arg Ile His Glu Arg 
145                 150                 155                 160


Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Gln Cys Gly Lys Ala 
                165                 170                 175


Phe Ser Trp Pro Ser Ser Phe Gln Ile His Glu Arg Thr His Thr Gly 
            180                 185                 190


Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Ile Tyr His 
        195                 200                 205


Thr Thr Phe Arg Gly His Met Arg Met His Thr Gly Glu Lys Pro Tyr 
    210                 215                 220


Lys Cys Lys Glu Cys Gly Lys Thr Phe Ser His Pro Ser Ser Phe Arg 
225                 230                 235                 240


Asn His Glu Arg Thr His Ser Gly Glu Lys Pro Tyr Glu Cys Lys Gln 
                245                 250                 255


Cys Gly Lys Ala Phe Arg Tyr Tyr Gln Thr Phe Gln Ile His Glu Arg 
            260                 265                 270


Thr His Thr Gly Glu Lys Pro Tyr Gln Cys Lys Gln Cys Gly Lys Ala 
        275                 280                 285


Leu Ser Cys Pro Thr Ser Phe Arg Ser His Glu Arg Ile His Thr Gly 
    290                 295                 300


Glu Lys Pro Tyr Lys Cys Lys Lys Cys Gly Lys Ala Phe Ser Phe Pro 
305                 310                 315                 320


Ser Ser Phe Arg Lys His Glu Arg Ile His Thr Gly Glu Lys Pro Tyr 
                325                 330                 335


Asp Cys Lys Glu Cys Gly Lys Ala Phe Ile Ser Leu Pro Ser Tyr Arg 
            340                 345                 350


Arg His Met Ile Met His Thr Gly Asn Gly Pro Tyr Lys Cys Lys Glu 
        355                 360                 365


Cys Gly Lys Ala Phe Asp Cys Pro Ser Ser Phe Gln Ile His Glu Arg 
    370                 375                 380


Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys Ala 
385                 390                 395                 400


Phe Ser Cys Ser Ser Ser Phe Arg Met His Glu Arg Thr His Thr Gly 
                405                 410                 415


Glu Lys Pro His Glu Cys Lys Gln Cys Gly Lys Ala Phe Ser Cys Ser 
            420                 425                 430


Ser Ser Val Arg Ile His Glu Arg Thr His Thr Gly Glu Lys Pro Tyr 
        435                 440                 445


Glu Cys Lys Gln Cys Gly Lys Ala Phe Ser Cys Ser Ser Ser Phe Arg 
    450                 455                 460


Met His Glu Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Gln 
465                 470                 475                 480


Cys Gly Lys Ala Phe Ser Phe Ser Ser Ser Phe Arg Met His Glu Arg 
                485                 490                 495


Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys Ala 
            500                 505                 510


Phe Ser Cys Ser Ser Ser Phe Arg Met His Glu Arg Thr His Thr Gly 
        515                 520                 525


Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys Ala Phe Ser Cys Ser 
    530                 535                 540


Ser Ser Ile Arg Ile His Glu Arg Thr His Thr Gly Glu Lys Pro Tyr 
545                 550                 555                 560


Glu Cys Lys Gln Cys Gly Lys Ala Phe Ser Cys Ser Ser Ser Val Arg 
                565                 570                 575


Met His Glu Arg Thr His Thr Gly Val Lys Pro Tyr Glu Cys Lys Gln 
            580                 585                 590


Cys Asp Lys Ala Phe Ser Cys Ser Arg Ser Phe Arg Ile His Glu Arg 
        595                 600                 605


Thr His Thr Gly Glu Lys Pro Tyr Ala Cys Gln Gln Cys Gly Lys Ala 
    610                 615                 620


Phe Lys Cys Ser Arg Ser Phe Arg Ile His Glu Arg Val His Ser Gly 
625                 630                 635                 640


Glu 



<210>  1168
<211>  2553
<212>  DNA
<213>  Homo sapiens

<400>  1168
aatgttcaac aactccgcgg ggtcttcctg tttcgtgtcc gctgcgtttg ggttccggtc     60

tccgcttctc cagtggcccc ggtggctcca ccgcagcgtc tggcgcgctg ggacctgcac    120

aggccggaga gagccgtagg caggaccccg ggacaccctg gaagccagga aatggactca    180

gtggcctctg aggatgtggc tgtgaacttc acacttgagg agtgggcttt gctggatcct    240

tcccagaaga aactctacag agatgtgatg cgggaaacct ttagaaacct ggcctgtgta    300

ggaaaaaaat gggaagacca gagcattgaa gattggtaca aaaatcaggg gagaatttta    360

agaaatcata tggaagaggg actcagtgaa agtaaagaat atgatcaatg tggagaagcc    420

ttcagtcaga ttctcaatct taatctgaac aagaaaattc ctactatagt aagaccatgt    480

gaatgtagtt tgtgtgggaa agtcttcatg catcattcat cccttagtag gcacatcaga    540

tctcaccttg gacacaaacc atatgactat caggaatatg gagagaaacc atataaatgt    600

aagcagtgtg ggaaagcctt cagttcttgt caatcctttc gaagacatga aagaactcac    660

actggtgaga aaccctatgc atgtccggaa tgtgggaaag ccttcatttc tctcccaagt    720

gttcgaagac acatgattaa gcacactgga gatggaccat ataaatgtca ggaatgtggg    780

aaagcctttg atcgcccaag tttatttcag atacatgaaa gaactcacac tggagagaaa    840

ccctatgaat gtcaggaatg tgcaaaagct ttcatttctc ttccaagttt tcaaagacac    900

atgattaggc acactggaga tggaccttat aaatgtcagg aatgtggaaa agcctttgac    960

cgccccagtt tatttcgaat acatgaaaga actcatactg gagagaaacc ccatgaatgt   1020

aaacagtgtg ggaaggcctt catttctttc acaaattttc aaagtcatat gattaggcac   1080

actggggatg gaccttataa atgtaaagta tgtgggagag cctttatttt tcccagttat   1140

gttcgaaagc atgaaagaac tcatactggg gagaaaccct atgaatgtaa taaatgtggt   1200

aaaaccttca gttcttccag taatgttcga acacatgaaa ggactcacac tggagagaag   1260

ccctatgaat gtaaggaatg cgggaaagcc ttcatttctc tcccaagtgt ccgaagacac   1320

atgataaagc acactggaga tggaccttat aaatgtcagg tatgtggtag agcctttgac   1380

tgtcccagtt catttcaaat acacgaaaga actcacactg gagagaaacc ctatgaatgt   1440

caggtatgtg ggaaagcctt catttctctt aaaaggatta gaaaacatat gatactgcac   1500

actggagatg gaccttataa atgtcaggta tgtggtaaag cctttgactg tcctagttct   1560

gtccgaacac atgaaagaac tcatactgga gaaaaaccct atgaatgtaa agaatgtggg   1620

aaagcattca attatgccag ttccattaga atacatgaaa gaactcatac cggagaaaaa   1680

ccctatgaat gtaagcaatg tggaaaaacg ttcagttatt ccagttcctt tcaaagacat   1740

gaaagagctc ataatggaga taaaccttac gtaaagaatg tgggaaagct ttcatttatc   1800

acacaacctt cgaatacctg tgaaaatgaa tagtggagga caggtctaca agtatctaca   1860

tatctaaaga atatggaaag tcttcagttt gctttctggg tttcagactt gtttgggagc   1920

tcaccccttt ctcctgtttc tcacttttgg aataggaatc tctatcctgt gcctgtctca   1980

tattttggaa atacatgact agtttggttt tcaccggttc ggagctgaag aagaattttg   2040

cctcagcatg aattgagtct catccatatc tgagtgatgt gatattgaga tgacactttg   2100

gagtttgagt ttaaacatta ggcttcatgc tggaattaac tgagactttt gaggcctttg   2160

ggatgagatg aatatatttt acatgtgatg acatggattt tgggggccag aggtgtaatg   2220

ttttggctga gtgtatgcca cctcagattc atatgttgaa accttacccc cgtgcccccc   2280

ctctccccca caatgtgatg gtatttggag gccctgtctc tggtggtttt taggattgga   2340

ggacatcatg aagatggagg ccttgtaatt gggattagtt tcctgatagg aatccctaga   2400

gagctagctt tgcccttcac catgagaggg tgcagtgaga agatagctat ctttgaaccg   2460

ggaagcaggc ccttaccaga catggactat gccagtgcct tgatattgga cttcccagcc   2520

tcccaaacca tgagaaataa atgtttgttg att                                2553


<210>  1169
<211>  553
<212>  PRT
<213>  Homo sapiens

<400>  1169

Met Asp Ser Val Ala Ser Glu Asp Val Ala Val Asn Phe Thr Leu Glu 
1               5                   10                  15


Glu Trp Ala Leu Leu Asp Pro Ser Gln Lys Lys Leu Tyr Arg Asp Val 
            20                  25                  30


Met Arg Glu Thr Phe Arg Asn Leu Ala Cys Val Gly Lys Lys Trp Glu 
        35                  40                  45


Asp Gln Ser Ile Glu Asp Trp Tyr Lys Asn Gln Gly Arg Ile Leu Arg 
    50                  55                  60


Asn His Met Glu Glu Gly Leu Ser Glu Ser Lys Glu Tyr Asp Gln Cys 
65                  70                  75                  80


Gly Glu Ala Phe Ser Gln Ile Leu Asn Leu Asn Leu Asn Lys Lys Ile 
                85                  90                  95


Pro Thr Ile Val Arg Pro Cys Glu Cys Ser Leu Cys Gly Lys Val Phe 
            100                 105                 110


Met His His Ser Ser Leu Ser Arg His Ile Arg Ser His Leu Gly His 
        115                 120                 125


Lys Pro Tyr Asp Tyr Gln Glu Tyr Gly Glu Lys Pro Tyr Lys Cys Lys 
    130                 135                 140


Gln Cys Gly Lys Ala Phe Ser Ser Cys Gln Ser Phe Arg Arg His Glu 
145                 150                 155                 160


Arg Thr His Thr Gly Glu Lys Pro Tyr Ala Cys Pro Glu Cys Gly Lys 
                165                 170                 175


Ala Phe Ile Ser Leu Pro Ser Val Arg Arg His Met Ile Lys His Thr 
            180                 185                 190


Gly Asp Gly Pro Tyr Lys Cys Gln Glu Cys Gly Lys Ala Phe Asp Arg 
        195                 200                 205


Pro Ser Leu Phe Gln Ile His Glu Arg Thr His Thr Gly Glu Lys Pro 
    210                 215                 220


Tyr Glu Cys Gln Glu Cys Ala Lys Ala Phe Ile Ser Leu Pro Ser Phe 
225                 230                 235                 240


Gln Arg His Met Ile Arg His Thr Gly Asp Gly Pro Tyr Lys Cys Gln 
                245                 250                 255


Glu Cys Gly Lys Ala Phe Asp Arg Pro Ser Leu Phe Arg Ile His Glu 
            260                 265                 270


Arg Thr His Thr Gly Glu Lys Pro His Glu Cys Lys Gln Cys Gly Lys 
        275                 280                 285


Ala Phe Ile Ser Phe Thr Asn Phe Gln Ser His Met Ile Arg His Thr 
    290                 295                 300


Gly Asp Gly Pro Tyr Lys Cys Lys Val Cys Gly Arg Ala Phe Ile Phe 
305                 310                 315                 320


Pro Ser Tyr Val Arg Lys His Glu Arg Thr His Thr Gly Glu Lys Pro 
                325                 330                 335


Tyr Glu Cys Asn Lys Cys Gly Lys Thr Phe Ser Ser Ser Ser Asn Val 
            340                 345                 350


Arg Thr His Glu Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys 
        355                 360                 365


Glu Cys Gly Lys Ala Phe Ile Ser Leu Pro Ser Val Arg Arg His Met 
    370                 375                 380


Ile Lys His Thr Gly Asp Gly Pro Tyr Lys Cys Gln Val Cys Gly Arg 
385                 390                 395                 400


Ala Phe Asp Cys Pro Ser Ser Phe Gln Ile His Glu Arg Thr His Thr 
                405                 410                 415


Gly Glu Lys Pro Tyr Glu Cys Gln Val Cys Gly Lys Ala Phe Ile Ser 
            420                 425                 430


Leu Lys Arg Ile Arg Lys His Met Ile Leu His Thr Gly Asp Gly Pro 
        435                 440                 445


Tyr Lys Cys Gln Val Cys Gly Lys Ala Phe Asp Cys Pro Ser Ser Val 
    450                 455                 460


Arg Thr His Glu Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys 
465                 470                 475                 480


Glu Cys Gly Lys Ala Phe Asn Tyr Ala Ser Ser Ile Arg Ile His Glu 
                485                 490                 495


Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys 
            500                 505                 510


Thr Phe Ser Tyr Ser Ser Ser Phe Gln Arg His Glu Arg Ala His Asn 
        515                 520                 525


Gly Asp Lys Pro Tyr Val Lys Asn Val Gly Lys Leu Ser Phe Ile Thr 
    530                 535                 540


Gln Pro Ser Asn Thr Cys Glu Asn Glu 
545                 550


<210>  1170
<211>  1690
<212>  DNA
<213>  Homo sapiens

<400>  1170
atggaggcca cgccccccct ctgccctagt tggccctggt tacaccttct ctggtcagtc     60

tcacagctgc gcggtggcag acaggacttg ttccacagtg gtaactggga tagagctgat    120

gtggccccaa ccccacctcc cttcccgccc tgccatgtcg gaagaaaccc gacgagcaaa    180

ttggcagcag caaagaaaaa gttgagagac tatcagtgga ggaacagccc tggtgttcct    240

acaggagtga aaaagaaaat taaaaattgc agtaaccccg agacaaccac ttctggtggt    300

tgccactcac ctggagatgt aatggaggca tgtagacaaa tacaactgga gagagataca    360

tttgctgaga ttcttaaagg agagagagcc acatggcagc agaggatgaa tcagatgtcg    420

gagcagatgc acacactgag ggaggagaag gagtgtatta tgaatcggtt acaggagctg    480

gagacaagct tggtggaatt gagaaaacag atgactgaac tcccagccct ggcaccccca    540

gcaaggccct ccgaggtgga gcagcagcta caagaggagg ctgagcacct gagggaggag    600

ctggagagtc tggcaggaca gctccaagcc caggtacagg acaatgaggg cttgagttgc    660

ctgaaccggg agcaggagga gaggctgctg gagctggagc gggcagctga gctctggcgg    720

aagcaagagg aggatgagga tgaggaggag aaggagaagg agaagaagaa gaagaagaag    780

gaggagaagg agaaggagga ggaggcgtct cggcccatga agagcatcct gcaggacctg    840

gaaagccagg agtccatggt ggcattttta acatcagctg tagccagtgc agatggggag    900

caggctcggc tccgtgggca gctgaaggag caaaggctgc gctgccggtg cctggctcac    960

ctgctggcct gggcccagaa gcagccagag gcagcagccc cagccccagg gactgggatg   1020

gattctagct gctttatgca gctgatgcag gaaaaggtgg acctgaaaga gcgggtggag   1080

gagctggaac atcgctgcat ccagctctct ggagagacag acaccatcgg agtctacact   1140

gccctctctc agccaggggg cagcgctgaa ggagcagcac cgagaggagg aggagcacat   1200

ccacaggcta gcccaggaca aggaggagat gaaggtgaag ctgctggagt tgcaggagct   1260

ggtgttgcgg cttgtgggcg acaggactga gggccatggc agattcctgg cagctgccca   1320

gagccctgct catgagccag ctccaggggc cccagccccc cagagctcag ggctgccgac   1380

aagcagggtg atgagtagtg ccctcaggcg gtttgggcag gcaagagcaa gggaggctgg   1440

cagtgtgctc agagccctcc tccctctctc caaagatctt tgccaggtga ccctcaccag   1500

cagcgtggag cctgcacaag gagaggccgg ggagggttct cccctcgaca accccagtgc   1560

acagcagatc atgcagctgt ttggtgagat gcagaaccct caggagcgcc caggcttggg   1620

cagcatcccc tgcattctgt tttcccacca ggctgacaaa aaccaccagg tgaagatcac   1680

cctcatctga                                                          1690


<210>  1171
<211>  790
<212>  DNA
<213>  Homo sapiens

<400>  1171
atggtccagc gtttgacata ccaatgtagg cattcctaca gtacagcctc taacaaaagt     60

aggctgttcc gaacccctgg taatagaata cctttatacc aagaaggttg gaaaagcatc    120

aaaatctgct tgtggcatgt gcccaggcag acttcgaggg gttcgtgctg taagacttaa    180

agttcttatg aaattgtcca aaacaaacaa acatgtcagc agggcctatg gtggttccat    240

gtgtgctaaa tgtgttcgtg gcaggatcaa gcgtgctttc cttattgagg agcagaaaat    300

cgttgtgaaa gtgttgaagg cacaagcaga gtcttctcac tcattttatt tagctttgca    360

gctaaataaa aactctaggc agtttctcct ggttcttctg ttcctggcgt ctgagatttg    420

tcagcagggc cagattttca ggaaccatgc atggctatcg cctcctcccg cctggagggc    480

tgctcctgcg cctctgaccg gcgctggttc cagccgcggc ccagctgagc acagcaggaa    540

ccgcagtagc agccggagcg cccacgcccg gggtcgccta gcccaggaac gccttagttg    600

caaccctgcg tcgaggccca gctccgtgcg cagaaagccg aggccaacca gagcatttcc    660

tggacgagtc ctctcggcct gcggggccag ttcctcctac cagcttcctg ctgccacctc    720

ggcttccatc agagggacgc ttaggatggc gcaggggccc ggagacactg tgaagagtcc    780

aggggaatga                                                           790


<210>  1172
<211>  2011
<212>  DNA
<213>  Homo sapiens

<400>  1172
cagagacagc cagacccccg gggacccagc ctctcacagt cagtcctccc acccgagtga     60

ccccgatggc ggcctcccag ctggcggcgc tggaaggagt ggactccggt cccagggtgc    120

ccggggccag ccccggcttt ctatattccg agggccagcg gctggcactg gaggctctgt    180

tgagcaaggg cgcggaggcg ttccagacct gcgtgcagcg cgaggagctg tggcccttcc    240

tcagtgcgga tgaggttcag ggcttggcag cggcagctga agactggaca gtggccaagc    300

aggagcccag cgggatggca gagggagcca ccaccaccga tgtggacgcg ggcagcctga    360

gctactggcc tgggcagtcg gagcagccgg cgcccgtcct gcggctgggc tggccagtgg    420

actctgcgtg gaaaggcatc acccgggcgc agctgtacac ccagcctcct ggagagggtc    480

agccgcccct caaggagctg gtgcggctgg agatccaggc tgcccacaag ctggtggccg    540

tggtcatgga cgtcttcact gacccagacc tgcttttgga cttggtggat gctgccacgc    600

gccgctgggt acctgtctac ctgctcctgg accgccagca gctgcctgcc ttcctggaac    660

tggcccagca gctgggggtg aacccctgga acacggagaa cgtggatgtc cgtgtcgtgc    720

ggggctgcag cttccagagc cgctggcgac ggcaggtgag cggcaccgtg cgggagaagt    780

ttgtgctgct ggacggcgag agggtcatct caggatccta cagcttcacg tggagtgacg    840

cacgcctgca ccgaggcctg gtgaccctgc tgactggtga aattgttgac gccttcagcc    900

ttgagttccg gacgctgtac gcggcctcct gcccgctccc acctgcgccc ccccagaaac    960

cctcggtcat aggtggcctg cagcggggcc gcagcccgca ccgcgtgtcc cgccgccgct   1020

ccgtggcccc cgcgtcgcct ccgccgcctg acggcccgct ggcccaccgc ctggccgcct   1080

gccgcgtctc ccctgctacc ccggggccgg cactcagtga cattctaagg agtgtgcagc   1140

gcgcccggac ccccagcggc cccccggccc ggcccagccg ctccatgtgg gacctaagcc   1200

gcctgtccca gctgtctggc tccagtgatg gggacaacga gctcaagaaa tcctggggct   1260

ccaaggacac tccagccaag gctctgatga ggcagcgggg cactggagga ggcccctggg   1320

gggaagtgga ctcccgacct ccgtggggcg gtgccctgcc cctgcccccc gcccaccgcc   1380

tccgctatct gtccccagcc cgaaggcggt tcggtgggga tgctacattc aaacttcaag   1440

agcccagagg cgtcaggccg tcagactggg ccccccgggc aggacttggg gggcaaccct   1500

gaacaggagc ccaagccaaa tctgctggcc cacccaagga gcagtgccgg acaactgtcg   1560

gctcagagcc ctctgcctca atgccctgcc ttggacaagg cttctggcct cggcgtctgt   1620

caagcagaag ggatgtttgt cacttgttct gcaacttggg ccgggagtgg tggctcatgc   1680

ctgtaatccc tgcactttgg gaggctaagg tgggagggtt gcttaaggcc aggagttgga   1740

gaccagcctg ggcaacatag tgagacccca tctctacaat taaaaaaaca aattagttgg   1800

gtgtggtggc gcacgcctgt ggtcccagct acgcaggagg ctgaggtggg aggatccctt   1860

gagctcagga ggtggaggca gcagtgagcc aagatcatgc ccttgcactc cagcctgggc   1920

aacacagtga gaggccatct ctttaaaaaa aaaaaaaaaa gaaaaaagaa aaagaaaggc   1980

tgatcgaggt ggctcactcc tgtaatccca g                                  2011


<210>  1173
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  1173

Met Ala Ala Ser Gln Leu Ala Ala Leu Glu Gly Val Asp Ser Gly Pro 
1               5                   10                  15


Arg Val Pro Gly Ala Ser Pro Gly Phe Leu Tyr Ser Glu Gly Gln Arg 
            20                  25                  30


Leu Ala Leu Glu Ala Leu Leu Ser Lys Gly Ala Glu Ala Phe Gln Thr 
        35                  40                  45


Cys Val Gln Arg Glu Glu Leu Trp Pro Phe Leu Ser Ala Asp Glu Val 
    50                  55                  60


Gln Gly Leu Ala Ala Ala Ala Glu Asp Trp Thr Val Ala Lys Gln Glu 
65                  70                  75                  80


Pro Ser Gly Met Ala Glu Gly Ala Thr Thr Thr Asp Val Asp Ala Gly 
                85                  90                  95


Ser Leu Ser Tyr Trp Pro Gly Gln Ser Glu Gln Pro Ala Pro Val Leu 
            100                 105                 110


Arg Leu Gly Trp Pro Val Asp Ser Ala Trp Lys Gly Ile Thr Arg Ala 
        115                 120                 125


Gln Leu Tyr Thr Gln Pro Pro Gly Glu Gly Gln Pro Pro Leu Lys Glu 
    130                 135                 140


Leu Val Arg Leu Glu Ile Gln Ala Ala His Lys Leu Val Ala Val Val 
145                 150                 155                 160


Met Asp Val Phe Thr Asp Pro Asp Leu Leu Leu Asp Leu Val Asp Ala 
                165                 170                 175


Ala Thr Arg Arg Trp Val Pro Val Tyr Leu Leu Leu Asp Arg Gln Gln 
            180                 185                 190


Leu Pro Ala Phe Leu Glu Leu Ala Gln Gln Leu Gly Val Asn Pro Trp 
        195                 200                 205


Asn Thr Glu Asn Val Asp Val Arg Val Val Arg Gly Cys Ser Phe Gln 
    210                 215                 220


Ser Arg Trp Arg Arg Gln Val Ser Gly Thr Val Arg Glu Lys Phe Val 
225                 230                 235                 240


Leu Leu Asp Gly Glu Arg Val Ile Ser Gly Ser Tyr Ser Phe Thr Trp 
                245                 250                 255


Ser Asp Ala Arg Leu His Arg Gly Leu Val Thr Leu Leu Thr Gly Glu 
            260                 265                 270


Ile Val Asp Ala Phe Ser Leu Glu Phe Arg Thr Leu Tyr Ala Ala Ser 
        275                 280                 285


Cys Pro Leu Pro Pro Ala Pro Pro Gln Lys Pro Ser Val Ile Gly Gly 
    290                 295                 300


Leu Gln Arg Gly Arg Ser Pro His Arg Val Ser Arg Arg Arg Ser Val 
305                 310                 315                 320


Ala Pro Ala Ser Pro Pro Pro Pro Asp Gly Pro Leu Ala His Arg Leu 
                325                 330                 335


Ala Ala Cys Arg Val Ser Pro Ala Thr Pro Gly Pro Ala Leu Ser Asp 
            340                 345                 350


Ile Leu Arg Ser Val Gln Arg Ala Arg Thr Pro Ser Gly Pro Pro Ala 
        355                 360                 365


Arg Pro Ser Arg Ser Met Trp Asp Leu Ser Arg Leu Ser Gln Leu Ser 
    370                 375                 380


Gly Ser Ser Asp Gly Asp Asn Glu Leu Lys Lys Ser Trp Gly Ser Lys 
385                 390                 395                 400


Asp Thr Pro Ala Lys Ala Leu Met Arg Gln Arg Gly Thr Gly Gly Gly 
                405                 410                 415


Pro Trp Gly Glu Val Asp Ser Arg Pro Pro Trp Gly Gly Ala Leu Pro 
            420                 425                 430


Leu Pro Pro Ala His Arg Leu Arg Tyr Leu Ser Pro Ala Arg Arg Arg 
        435                 440                 445


Phe Gly Gly Asp Ala Thr Phe Lys Leu Gln Glu Pro Arg Gly Val Arg 
    450                 455                 460


Pro Ser Asp Trp Ala Pro Arg Ala Gly Leu Gly Gly Gln Pro 
465                 470                 475


<210>  1174
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  1174
ctttccggac ctggccgagc aggaggcgcc atcatgggag tggacatccg ccataacaag     60

gaccgaaagg ttcggcgcaa ggagcccaag agccaggata tctacctgag gctgttggtc    120

aagttataca ggtttctggc cagaagaacc aactccacat tcaaccaggt tgtgttgaag    180

aggttgttta tgagtcgcac caaccggccg cctctgtccc tttcccggat gatccggaag    240

atgaagcttc ctggccggga aaacaagacg gccgtggttg tggggaccat aactgatgat    300

gtgcgggttc aggaggtacc caaactgaag gtatgtgcac tgcgcgtgac cagccgggcc    360

cgcagccgca tcctcagggc agggggcaag atcctcactt tcgaccagct ggccctggac    420

tcccctaagg gctgtggcac tgtcctgctc tccggtcctc gcaagggccg agaggtgtac    480

cggcatttcg gcaaggcccc aggaaccccg cacagccaca ccaaacccta cgtccgctcc    540

aagggccgga agttcgagcg tgccagaggc cgacgggcca gccgaggcta caaaaactaa    600

ccctggatcc tactctctta ttaaaaagat ttttgctgac aaaaaaaa                 648


<210>  1175
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  1175

Met Gly Val Asp Ile Arg His Asn Lys Asp Arg Lys Val Arg Arg Lys 
1               5                   10                  15


Glu Pro Lys Ser Gln Asp Ile Tyr Leu Arg Leu Leu Val Lys Leu Tyr 
            20                  25                  30


Arg Phe Leu Ala Arg Arg Thr Asn Ser Thr Phe Asn Gln Val Val Leu 
        35                  40                  45


Lys Arg Leu Phe Met Ser Arg Thr Asn Arg Pro Pro Leu Ser Leu Ser 
    50                  55                  60


Arg Met Ile Arg Lys Met Lys Leu Pro Gly Arg Glu Asn Lys Thr Ala 
65                  70                  75                  80


Val Val Val Gly Thr Ile Thr Asp Asp Val Arg Val Gln Glu Val Pro 
                85                  90                  95


Lys Leu Lys Val Cys Ala Leu Arg Val Thr Ser Arg Ala Arg Ser Arg 
            100                 105                 110


Ile Leu Arg Ala Gly Gly Lys Ile Leu Thr Phe Asp Gln Leu Ala Leu 
        115                 120                 125


Asp Ser Pro Lys Gly Cys Gly Thr Val Leu Leu Ser Gly Pro Arg Lys 
    130                 135                 140


Gly Arg Glu Val Tyr Arg His Phe Gly Lys Ala Pro Gly Thr Pro His 
145                 150                 155                 160


Ser His Thr Lys Pro Tyr Val Arg Ser Lys Gly Arg Lys Phe Glu Arg 
                165                 170                 175


Ala Arg Gly Arg Arg Ala Ser Arg Gly Tyr Lys Asn 
            180                 185


<210>  1176
<211>  3012
<212>  DNA
<213>  Homo sapiens

<400>  1176
cgactgacta gccgggcgat aacggcagag agcatagagc gcaggaacaa gcgcaacgtc     60

caagagggaa gggccagcac gtcgggggcc tctctggccc tacccaggcc gtgttctcga    120

tagctttccg gaagaaaggg atctgggagc gagatgcgtg tagctagcac gatgcgtcgc    180

gcggtgacgc tctggcccga cgccgacggc ctctcagtgg ctcccggagg acccggcggg    240

cccagtgttg gagagctgaa ggtcaggcca ggacagtgag acctgactcc ttgctcctac    300

cagcctacta tggcttaaga cccagggcca gggtcccgtt gatgtaacag agcagaggac    360

cagcagatga atggacacct tgaagcagag gagcagcagg accagaggcc agaccaggag    420

ctgaccggga gctggggcca cgggcctagg agcaccctgg tcagggctaa ggccatggcc    480

ccgcccccac cgccactggc tgccagcacc ccgctcctcc atggcgagtt tggctcctac    540

ccagcccgag gcccacgctt tgccctcacc cttacatcgc aggccctgca catacagcgg    600

ctgcgcccca aacctgaagc caggccccgg ggtggcctgg tcccgttggc cgaggtctca    660

ggctgctgca ccctgcgaag ccgcagcccc tcagactcag cggcctactt ctgcatctac    720

acctaccctc ggggccggcg cggggcccgg cgcagagcca ctcgcacctt ccgggcagat    780

ggggccgcca cctacgaaga gaaccgtgcc gaggcccagc gctgggccac tgccctcacc    840

tgtctgctcc gaggactgcc actgcccggg gatggggaga tcacccctga cctgctacct    900

cggccgcccc ggttgcttct attggtcaat ccctttgggg gtcggggcct ggcctggcag    960

tggtgtaaga accacgtgct tcccatgatc tctgaagctg ggctgtcctt caacctcatc   1020

cagacagaac gacagaacca cgcccgggag ctggtccagg ggctgagcct gagtgagtgg   1080

gatggcatcg tcacggtctc gggagacggg ctgctccatg aggtgctgaa cgggctccta   1140

gatcgccctg actgggagga agctgtgaag atgcctgtgg gcatcctccc ctgcggctcg   1200

ggcaacgcgc tggccggagc agtgaaccag cacgggggat ttgagccagc cctgggcctc   1260

gacctgttgc tcaactgctc actgttgctg tgccggggtg gtggccaccc actggacctg   1320

ctctccgtga cgctggcctc gggctcccgc tgtttctcct tcctgtctgt ggcctggggc   1380

ttcgtgtcag atgtggatat ccagagcgag cgcttcaggg ccttgggcag tgcccgcttc   1440

acactgggca cggtgctggg cctcgccaca ctgcacacct accgcggacg cctctcctac   1500

ctccccgcca ctgtggaacc tgcctcgccc acccctgccc atagcctgcc tcgtgccaag   1560

tcggagctga ccctaacccc agacccagcc ccgcccatgg cccactcacc cctgcatcgt   1620

tctgtgtctg acctgcctct tcccctgccc cagcctgccc tggcctctcc tggctcgcca   1680

gaacccctgc ccatcctgtc cctcaacggt gggggcccag agctggctgg ggactggggt   1740

ggggctgggg atgctccgct gtccccggac ccactgctgt cttcacctcc tggctctccc   1800

aaggcagctc tacactcacc cgtctccgaa ggggcccccg taattccccc atcctctggg   1860

ctcccacttc ccacccctga tgcccgggta ggggcctcca cctgcggccc gcccgaccac   1920

ctgctgcctc cgctgggcac cccgctgccc ccagactggg tgacgctgga gggggacttt   1980

gtgctcatgt tggccatctc gcccagccac ctaggcgctg acctggtggc agctccgcat   2040

gcgcgcttcg acgacggcct ggtgcacctg tgctgggtgc gtagcggcat ctcgcgggct   2100

gcgctgctgc gccttttctt ggccatggag cgtggtagcc acttcagcct gggctgtccg   2160

cagctgggct acgccgcggc ccgtgccttc cgcctagagc cgctcacacc acgcggcgtg   2220

ctcacagtgg acggggagca ggtggagtat gggccgctac aggcacagat gcaccctggc   2280

atcggtacac tgctcactgg gcctcctggc tgcccggggc gggagccctg aaactaaaca   2340

agcttggtac ccgccggggg cggggcctac attccaatgg ggcggagcct gagctagggg   2400

gtgtggcctg gctgctagag ttgtggtggc aggggccctg gccccgtctc aggattgcgc   2460

tcgctttcat gggaccagac gtgatgctgg aaggtgggcg tcgtcacggt taaagagaaa   2520

tgggctcgtc ccgagggtag tgcctgatca atgagggcgg ggcctggcgt ctgatctggg   2580

gccgccctta cggggcaggg ctcagtcctg acgcttgcca cctgctccta cccggccagg   2640

atggctgagg gcggagtcta ttttacgcgt cgcccaatga caggacctgg aatgtactgg   2700

ctggggtagg cctcagtgag tcggccggtc agggcccgca gcctcgcccc atccactccg   2760

gtgcctccat ttagctggcc aatcagccca ggaggggcag gttccccggg gccggcgcta   2820

ggatttgcac taatgttcct ctccccgcgg gtgggggcgg ggaaattcat atcccctgtt   2880

cgtctcatgc gcgtcctccg tccccaatct aaaaagcaat tgaaaaggtc tatgcaataa   2940

aggcagtcgc ttcattcctc tcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3000

aaaaaaaaaa aa                                                       3012


<210>  1177
<211>  654
<212>  PRT
<213>  Homo sapiens

<400>  1177

Met Asn Gly His Leu Glu Ala Glu Glu Gln Gln Asp Gln Arg Pro Asp 
1               5                   10                  15


Gln Glu Leu Thr Gly Ser Trp Gly His Gly Pro Arg Ser Thr Leu Val 
            20                  25                  30


Arg Ala Lys Ala Met Ala Pro Pro Pro Pro Pro Leu Ala Ala Ser Thr 
        35                  40                  45


Pro Leu Leu His Gly Glu Phe Gly Ser Tyr Pro Ala Arg Gly Pro Arg 
    50                  55                  60


Phe Ala Leu Thr Leu Thr Ser Gln Ala Leu His Ile Gln Arg Leu Arg 
65                  70                  75                  80


Pro Lys Pro Glu Ala Arg Pro Arg Gly Gly Leu Val Pro Leu Ala Glu 
                85                  90                  95


Val Ser Gly Cys Cys Thr Leu Arg Ser Arg Ser Pro Ser Asp Ser Ala 
            100                 105                 110


Ala Tyr Phe Cys Ile Tyr Thr Tyr Pro Arg Gly Arg Arg Gly Ala Arg 
        115                 120                 125


Arg Arg Ala Thr Arg Thr Phe Arg Ala Asp Gly Ala Ala Thr Tyr Glu 
    130                 135                 140


Glu Asn Arg Ala Glu Ala Gln Arg Trp Ala Thr Ala Leu Thr Cys Leu 
145                 150                 155                 160


Leu Arg Gly Leu Pro Leu Pro Gly Asp Gly Glu Ile Thr Pro Asp Leu 
                165                 170                 175


Leu Pro Arg Pro Pro Arg Leu Leu Leu Leu Val Asn Pro Phe Gly Gly 
            180                 185                 190


Arg Gly Leu Ala Trp Gln Trp Cys Lys Asn His Val Leu Pro Met Ile 
        195                 200                 205


Ser Glu Ala Gly Leu Ser Phe Asn Leu Ile Gln Thr Glu Arg Gln Asn 
    210                 215                 220


His Ala Arg Glu Leu Val Gln Gly Leu Ser Leu Ser Glu Trp Asp Gly 
225                 230                 235                 240


Ile Val Thr Val Ser Gly Asp Gly Leu Leu His Glu Val Leu Asn Gly 
                245                 250                 255


Leu Leu Asp Arg Pro Asp Trp Glu Glu Ala Val Lys Met Pro Val Gly 
            260                 265                 270


Ile Leu Pro Cys Gly Ser Gly Asn Ala Leu Ala Gly Ala Val Asn Gln 
        275                 280                 285


His Gly Gly Phe Glu Pro Ala Leu Gly Leu Asp Leu Leu Leu Asn Cys 
    290                 295                 300


Ser Leu Leu Leu Cys Arg Gly Gly Gly His Pro Leu Asp Leu Leu Ser 
305                 310                 315                 320


Val Thr Leu Ala Ser Gly Ser Arg Cys Phe Ser Phe Leu Ser Val Ala 
                325                 330                 335


Trp Gly Phe Val Ser Asp Val Asp Ile Gln Ser Glu Arg Phe Arg Ala 
            340                 345                 350


Leu Gly Ser Ala Arg Phe Thr Leu Gly Thr Val Leu Gly Leu Ala Thr 
        355                 360                 365


Leu His Thr Tyr Arg Gly Arg Leu Ser Tyr Leu Pro Ala Thr Val Glu 
    370                 375                 380


Pro Ala Ser Pro Thr Pro Ala His Ser Leu Pro Arg Ala Lys Ser Glu 
385                 390                 395                 400


Leu Thr Leu Thr Pro Asp Pro Ala Pro Pro Met Ala His Ser Pro Leu 
                405                 410                 415


His Arg Ser Val Ser Asp Leu Pro Leu Pro Leu Pro Gln Pro Ala Leu 
            420                 425                 430


Ala Ser Pro Gly Ser Pro Glu Pro Leu Pro Ile Leu Ser Leu Asn Gly 
        435                 440                 445


Gly Gly Pro Glu Leu Ala Gly Asp Trp Gly Gly Ala Gly Asp Ala Pro 
    450                 455                 460


Leu Ser Pro Asp Pro Leu Leu Ser Ser Pro Pro Gly Ser Pro Lys Ala 
465                 470                 475                 480


Ala Leu His Ser Pro Val Ser Glu Gly Ala Pro Val Ile Pro Pro Ser 
                485                 490                 495


Ser Gly Leu Pro Leu Pro Thr Pro Asp Ala Arg Val Gly Ala Ser Thr 
            500                 505                 510


Cys Gly Pro Pro Asp His Leu Leu Pro Pro Leu Gly Thr Pro Leu Pro 
        515                 520                 525


Pro Asp Trp Val Thr Leu Glu Gly Asp Phe Val Leu Met Leu Ala Ile 
    530                 535                 540


Ser Pro Ser His Leu Gly Ala Asp Leu Val Ala Ala Pro His Ala Arg 
545                 550                 555                 560


Phe Asp Asp Gly Leu Val His Leu Cys Trp Val Arg Ser Gly Ile Ser 
                565                 570                 575


Arg Ala Ala Leu Leu Arg Leu Phe Leu Ala Met Glu Arg Gly Ser His 
            580                 585                 590


Phe Ser Leu Gly Cys Pro Gln Leu Gly Tyr Ala Ala Ala Arg Ala Phe 
        595                 600                 605


Arg Leu Glu Pro Leu Thr Pro Arg Gly Val Leu Thr Val Asp Gly Glu 
    610                 615                 620


Gln Val Glu Tyr Gly Pro Leu Gln Ala Gln Met His Pro Gly Ile Gly 
625                 630                 635                 640


Thr Leu Leu Thr Gly Pro Pro Gly Cys Pro Gly Arg Glu Pro 
                645                 650


<210>  1178
<211>  1478
<212>  DNA
<213>  Homo sapiens

<400>  1178
cagattttgc aagagccagg ctcgcccacc ttgtagaagg agcgccttga gtcccctctc     60

accctcggtt gcaaagagcc gaccgcttga tctggacacc ccctcgccca gattgcatga    120

tctcccggga ccctcttgag ttgcacgttt ctgcaccgag gacctcaaat ccccgtcgct    180

cctaggattt gcagcgttct ggatactgga gggttgcagg ctacactcgc ccgcccctgg    240

gcagacactc gtccaaacca ctggagtgtg ctggtgactg gcaggccagc ccttcgcctc    300

tccatgaacc cgtgagcctg ggggcaggtg ccaggcgatg gcgcggcctg tgagcgacag    360

gaccccggcc cctctgctgc tgggcggccc ggccgggaca ccccctggcg ggggagcgct    420

gcttgggttg cggagccttc tgcaggggac cagcaagccc aaagagccgg ccagctgtct    480

cctgaaggaa aaggagcgca aggcggccct gcctgcagcc acaacccctg ggccaggcct    540

ggagactgcg ggcccggcgg atgccccggc tggggcagtg gtgggcggag ggtccccgcg    600

ggggcgcccg gggccggtgc ccgccccggg tctgttggcg ccactgctgt gggagcgcac    660

gctgccgttc ggcgatgtgg agtacgtaga cctggacgcc ttcctgctgg agcacgggct    720

cccgcccagc ccgccgcccc ccggtggccc gtcgccggag ccgtcgcccg cgcggacgcc    780

cgcaccctcc ccagggccgg gttcgtgcgg ctcggcttcc ccccgctcct ctcctgggca    840

cgcccccgcc cgggctgccc tcgggaccgc cagcggccac cgcgcaggcc tgacctctcg    900

ggacacaccc agccctgtgg acccagacac cgtggaggtg ttgatgacct ttgaacccga    960

cccagctgat cttgccctat caagcattcc tggccacgag acctttgacc ctcgaagaca   1020

tcgcttctca gaagaggaac ttaagcccca gccaatcatg aagaaggcaa gaaaaatcca   1080

ggtgccggag gagcagaagg atgagaaata ctggagccgg cggtacaaga acaacgaggc   1140

agccaagcgg tcccgtgacg cccggcggct caaggagaac cagatatcgg tgcgggcggc   1200

cttcctggag aaggagaacg ccctgctgcg gcaggaagtt gtggccgtgc gccaggagct   1260

gtcccactac cgcgccgtgc tgtcccgata ccaggcccag cacggggccc tgtgaggctg   1320

ccccacatcc ccacctggcg gagctctcct ccgccttgct gagacttacg ccctgttccc   1380

ttcctgccct gtggcccacg ggccggccag ctgggtgccc cagggacgtg ataatgcaga   1440

taaatacatt tatattttta agaaaaaaaa aaaaaaaa                           1478


<210>  1179
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  1179

Met Ala Arg Pro Val Ser Asp Arg Thr Pro Ala Pro Leu Leu Leu Gly 
1               5                   10                  15


Gly Pro Ala Gly Thr Pro Pro Gly Gly Gly Ala Leu Leu Gly Leu Arg 
            20                  25                  30


Ser Leu Leu Gln Gly Thr Ser Lys Pro Lys Glu Pro Ala Ser Cys Leu 
        35                  40                  45


Leu Lys Glu Lys Glu Arg Lys Ala Ala Leu Pro Ala Ala Thr Thr Pro 
    50                  55                  60


Gly Pro Gly Leu Glu Thr Ala Gly Pro Ala Asp Ala Pro Ala Gly Ala 
65                  70                  75                  80


Val Val Gly Gly Gly Ser Pro Arg Gly Arg Pro Gly Pro Val Pro Ala 
                85                  90                  95


Pro Gly Leu Leu Ala Pro Leu Leu Trp Glu Arg Thr Leu Pro Phe Gly 
            100                 105                 110


Asp Val Glu Tyr Val Asp Leu Asp Ala Phe Leu Leu Glu His Gly Leu 
        115                 120                 125


Pro Pro Ser Pro Pro Pro Pro Gly Gly Pro Ser Pro Glu Pro Ser Pro 
    130                 135                 140


Ala Arg Thr Pro Ala Pro Ser Pro Gly Pro Gly Ser Cys Gly Ser Ala 
145                 150                 155                 160


Ser Pro Arg Ser Ser Pro Gly His Ala Pro Ala Arg Ala Ala Leu Gly 
                165                 170                 175


Thr Ala Ser Gly His Arg Ala Gly Leu Thr Ser Arg Asp Thr Pro Ser 
            180                 185                 190


Pro Val Asp Pro Asp Thr Val Glu Val Leu Met Thr Phe Glu Pro Asp 
        195                 200                 205


Pro Ala Asp Leu Ala Leu Ser Ser Ile Pro Gly His Glu Thr Phe Asp 
    210                 215                 220


Pro Arg Arg His Arg Phe Ser Glu Glu Glu Leu Lys Pro Gln Pro Ile 
225                 230                 235                 240


Met Lys Lys Ala Arg Lys Ile Gln Val Pro Glu Glu Gln Lys Asp Glu 
                245                 250                 255


Lys Tyr Trp Ser Arg Arg Tyr Lys Asn Asn Glu Ala Ala Lys Arg Ser 
            260                 265                 270


Arg Asp Ala Arg Arg Leu Lys Glu Asn Gln Ile Ser Val Arg Ala Ala 
        275                 280                 285


Phe Leu Glu Lys Glu Asn Ala Leu Leu Arg Gln Glu Val Val Ala Val 
    290                 295                 300


Arg Gln Glu Leu Ser His Tyr Arg Ala Val Leu Ser Arg Tyr Gln Ala 
305                 310                 315                 320


Gln His Gly Ala Leu 
                325


<210>  1180
<211>  1686
<212>  DNA
<213>  Homo sapiens

<400>  1180
aagggacaag agagaagaga gactgaaaca gggagaagag gcaggagagg aggaggtggg     60

gagagcacga agctggaggc cgacactgag ggagggcggg aggaggtgaa gaaggagaga    120

ggggagaaga ggcaggagct ggaaaggaga gagggaggag gaggaggaga tgcgggatgg    180

agacctggag ttaggtggct tgggagagct taatgaaaag agaacggaga ggaggtgtgg    240

gttaggaacc aagaggtagc cctgggggca gcagaaggct gagaggagta ggaagatcag    300

gagctagagg gagactggag ggttccggga aaagagcaga ggaaagagga aagacacaga    360

gagacgggag agagaagaag agtgggtttg aagggcggat ctcagtccct ggctgctttg    420

gcatttgggg aactgggact ccctgtgggg aggagaggaa agctggaagt cctggaggga    480

cagggtccca gaaggagggg acagaggagc tgagagaggg gggcagggcg ttgggcaggg    540

gtccctcgga ggcctcctgg ggatgggggc tgcagctcgt ctgagcgccc ctcgagcgct    600

ggtactctgg gctgcactgg gggcagcagc tcacatcgga ccagcacctg accccgagga    660

ctggtggagc tacaaggata atctccaggg aaacttcgtg ccagggcctc ctttctgggg    720

cctggtgaat gcagcgtgga gtctgtgtgc tgtggggaag cggcagagcc ccgtggatgt    780

ggagctgaag agggttcttt atgacccctt tctgccccca ttaaggctca gcactggagg    840

agagaagctc cggggaacct tgtacaacac cggccgacat gtctccttcc tgcctgcacc    900

ccgacctgtg gtcaatgtgt ctggaggtcc cctcctttac agccaccgac tcagtgaact    960

gcggctgctg tttggagctc gcgacggagc cggctcggaa catcagatca accaccaggg   1020

cttctctgct gaggtgcagc tcattcactt caaccaggaa ctctacggga atttcagcgc   1080

tgcctcccgc ggccccaatg gcctggccat tctcagcctc tttgtcaacg ttgccagtac   1140

ctctaaccca ttcctcagtc gcctccttaa ccgcgacacc atcactcgca tctcctacaa   1200

gaatgatgcc tactttcttc aagacctgag cctggagctc ctgttccctg aatccttcgg   1260

cttcatcacc tatcagggct ctctcagcac cccgccctgc tccgagactg tcacctggat   1320

cctcattgac cgggccctca atatcacctc ccttcagatg cactccctga gactcctgag   1380

ccagaatcct ccatctcaga tcttccagag cctcagcggt aacagccggc ccctgcagcc   1440

cttggcccac agggcactga ggggcaacag ggacccccgg caccccgaga ggcgctgccg   1500

aggccccaac taccgcctgc atgtggatgg tgtcccccat ggtcgctgag actccccttc   1560

gaggattgca cccgcccgtc ctaagcctcc ccacaaggcg aggggagtta cccctaaaac   1620

aaagctatta aagggacaga atacttcctg tttaaaaaaa aaaaaaaaaa aaaaaaaaaa   1680

aaaaaa                                                              1686


<210>  1181
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  1181

Met Gly Ala Ala Ala Arg Leu Ser Ala Pro Arg Ala Leu Val Leu Trp 
1               5                   10                  15


Ala Ala Leu Gly Ala Ala Ala His Ile Gly Pro Ala Pro Asp Pro Glu 
            20                  25                  30


Asp Trp Trp Ser Tyr Lys Asp Asn Leu Gln Gly Asn Phe Val Pro Gly 
        35                  40                  45


Pro Pro Phe Trp Gly Leu Val Asn Ala Ala Trp Ser Leu Cys Ala Val 
    50                  55                  60


Gly Lys Arg Gln Ser Pro Val Asp Val Glu Leu Lys Arg Val Leu Tyr 
65                  70                  75                  80


Asp Pro Phe Leu Pro Pro Leu Arg Leu Ser Thr Gly Gly Glu Lys Leu 
                85                  90                  95


Arg Gly Thr Leu Tyr Asn Thr Gly Arg His Val Ser Phe Leu Pro Ala 
            100                 105                 110


Pro Arg Pro Val Val Asn Val Ser Gly Gly Pro Leu Leu Tyr Ser His 
        115                 120                 125


Arg Leu Ser Glu Leu Arg Leu Leu Phe Gly Ala Arg Asp Gly Ala Gly 
    130                 135                 140


Ser Glu His Gln Ile Asn His Gln Gly Phe Ser Ala Glu Val Gln Leu 
145                 150                 155                 160


Ile His Phe Asn Gln Glu Leu Tyr Gly Asn Phe Ser Ala Ala Ser Arg 
                165                 170                 175


Gly Pro Asn Gly Leu Ala Ile Leu Ser Leu Phe Val Asn Val Ala Ser 
            180                 185                 190


Thr Ser Asn Pro Phe Leu Ser Arg Leu Leu Asn Arg Asp Thr Ile Thr 
        195                 200                 205


Arg Ile Ser Tyr Lys Asn Asp Ala Tyr Phe Leu Gln Asp Leu Ser Leu 
    210                 215                 220


Glu Leu Leu Phe Pro Glu Ser Phe Gly Phe Ile Thr Tyr Gln Gly Ser 
225                 230                 235                 240


Leu Ser Thr Pro Pro Cys Ser Glu Thr Val Thr Trp Ile Leu Ile Asp 
                245                 250                 255


Arg Ala Leu Asn Ile Thr Ser Leu Gln Met His Ser Leu Arg Leu Leu 
            260                 265                 270


Ser Gln Asn Pro Pro Ser Gln Ile Phe Gln Ser Leu Ser Gly Asn Ser 
        275                 280                 285


Arg Pro Leu Gln Pro Leu Ala His Arg Ala Leu Arg Gly Asn Arg Asp 
    290                 295                 300


Pro Arg His Pro Glu Arg Arg Cys Arg Gly Pro Asn Tyr Arg Leu His 
305                 310                 315                 320


Val Asp Gly Val Pro His Gly Arg 
                325


<210>  1182
<211>  1898
<212>  DNA
<213>  Homo sapiens

<400>  1182
gagagcccac cgcgccacag cttggaggaa gagcctgcgg ggaactggct gcaggacgct     60

ctcttcttga gtgcaggtgc tggctctgct gtgaccatgc ccgtgacctt tgccctcctg    120

ctcctcctgg gccaggccac tgcggaccca tgctacgatc cacagggccg cccccaattc    180

tgcctcccgc cagtgacaca gctggctgcc gtggcggcct cctgccctca ggcctgtgcc    240

ctgtccccag gaaaccacct tggcgccagg gaaacctgca atggcagcct gactttggcc    300

ctgggtggcc ccttcctcct gacatctgtc agcttgcgct tctgtacccc aggaccccca    360

gccctcatcc tgtctgctgc ctgggcctca gggggtccct ggaggctgct gtggcacagg    420

cccgcctggc ctggggcctt agggggccct gaaagggtga ccttccactc cacaccaggt    480

cctaaggcca ctgtggcggc cagccacctc cgtgtggagt ttgggggcca ggccgggcta    540

gcggcagctg ggctgagagg ccgctgccag tgtcatggcc acgctgcccg ctgtgccgcc    600

cgtgcccggc ccccccgctg ccactgccgc caccatacca ctggcccggg gtgcgagagc    660

tgccgcccgt cccatcgaga ctggccctgg cggcctgcca cgccccggca cccccaccct    720

tgcctaccct gctcctgcaa ccagcacgcc cgacgctgcc ggttcaactc tgagctgttc    780

agactgtcgg gcggccggag tgggggtgtt tgtgagcggt gccgccacca cacagctggg    840

cggcactgcc actactgcca acctgggttc tggagggacc ctagccagcc tatcttcagc    900

cgcagggcct gcagagcctg ccagtgccac cctattgggg caacaggagg aacctgcaac    960

cagaccagtg ggcagtgcac ctgcaagtta ggggtcacag gcctgacctg caaccgctgt   1020

ggccctggct accagcagag ccgctccccc aggatgccct gccagcgaat tccagaggca   1080

acaaccaccc ttgccactac tcctggtgct tatagctctg accctcagtg tcaaaactac   1140

tgcaatatgt cggacaccag ggtacacatg agccttcgga ggtactgcca gcaggaccat   1200

gttctccgcg cgcaggtgct agcgtccgag gcggcgggcc cggcatggca gcggctggcc   1260

gtgcgcgtgc tggccgttta caagcagcgg gcgcagcccg tgcgacgcgg cgaccaggac   1320

gcctgggtgc cccgcgccga cctgacctgc ggctgcctgc gcctgcagcc aggcaccgac   1380

tacctgctgc tgggcagcgc cgtgggcgac cccgacccca cgcgcctcat cctcgaccgc   1440

cacggcctcg cgctgccatg gaggccgcgc tgggcccggc ccctgaagcg gctgcagcag   1500

gaggagcgcg ccggaggctg ccgcggcgtg cgggcaccca cacccagccc caggccggag   1560

cactagacgt gagatggggc tgcctcgagc accaacaaag taatttggga gcgactagga   1620

gctgagcctt ctacctcgac ggtgcactgc agagagccaa tcagacgtcg cagagccccg   1680

acgacactat gcttgcgccc acgccgagca ggcgtgcgga acttttagca aaaggcggca   1740

agcgggactt ctggtcccag catttcctcc tttggcctgt ggcttattcc ccgccagtga   1800

tctgtttccc ccaataaagt ctcaaatctt tgggaaaaaa aaaaaaaaaa aaaaaaaaaa   1860

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                           1898


<210>  1183
<211>  489
<212>  PRT
<213>  Homo sapiens

<400>  1183

Met Pro Val Thr Phe Ala Leu Leu Leu Leu Leu Gly Gln Ala Thr Ala 
1               5                   10                  15


Asp Pro Cys Tyr Asp Pro Gln Gly Arg Pro Gln Phe Cys Leu Pro Pro 
            20                  25                  30


Val Thr Gln Leu Ala Ala Val Ala Ala Ser Cys Pro Gln Ala Cys Ala 
        35                  40                  45


Leu Ser Pro Gly Asn His Leu Gly Ala Arg Glu Thr Cys Asn Gly Ser 
    50                  55                  60


Leu Thr Leu Ala Leu Gly Gly Pro Phe Leu Leu Thr Ser Val Ser Leu 
65                  70                  75                  80


Arg Phe Cys Thr Pro Gly Pro Pro Ala Leu Ile Leu Ser Ala Ala Trp 
                85                  90                  95


Ala Ser Gly Gly Pro Trp Arg Leu Leu Trp His Arg Pro Ala Trp Pro 
            100                 105                 110


Gly Ala Leu Gly Gly Pro Glu Arg Val Thr Phe His Ser Thr Pro Gly 
        115                 120                 125


Pro Lys Ala Thr Val Ala Ala Ser His Leu Arg Val Glu Phe Gly Gly 
    130                 135                 140


Gln Ala Gly Leu Ala Ala Ala Gly Leu Arg Gly Arg Cys Gln Cys His 
145                 150                 155                 160


Gly His Ala Ala Arg Cys Ala Ala Arg Ala Arg Pro Pro Arg Cys His 
                165                 170                 175


Cys Arg His His Thr Thr Gly Pro Gly Cys Glu Ser Cys Arg Pro Ser 
            180                 185                 190


His Arg Asp Trp Pro Trp Arg Pro Ala Thr Pro Arg His Pro His Pro 
        195                 200                 205


Cys Leu Pro Cys Ser Cys Asn Gln His Ala Arg Arg Cys Arg Phe Asn 
    210                 215                 220


Ser Glu Leu Phe Arg Leu Ser Gly Gly Arg Ser Gly Gly Val Cys Glu 
225                 230                 235                 240


Arg Cys Arg His His Thr Ala Gly Arg His Cys His Tyr Cys Gln Pro 
                245                 250                 255


Gly Phe Trp Arg Asp Pro Ser Gln Pro Ile Phe Ser Arg Arg Ala Cys 
            260                 265                 270


Arg Ala Cys Gln Cys His Pro Ile Gly Ala Thr Gly Gly Thr Cys Asn 
        275                 280                 285


Gln Thr Ser Gly Gln Cys Thr Cys Lys Leu Gly Val Thr Gly Leu Thr 
    290                 295                 300


Cys Asn Arg Cys Gly Pro Gly Tyr Gln Gln Ser Arg Ser Pro Arg Met 
305                 310                 315                 320


Pro Cys Gln Arg Ile Pro Glu Ala Thr Thr Thr Leu Ala Thr Thr Pro 
                325                 330                 335


Gly Ala Tyr Ser Ser Asp Pro Gln Cys Gln Asn Tyr Cys Asn Met Ser 
            340                 345                 350


Asp Thr Arg Val His Met Ser Leu Arg Arg Tyr Cys Gln Gln Asp His 
        355                 360                 365


Val Leu Arg Ala Gln Val Leu Ala Ser Glu Ala Ala Gly Pro Ala Trp 
    370                 375                 380


Gln Arg Leu Ala Val Arg Val Leu Ala Val Tyr Lys Gln Arg Ala Gln 
385                 390                 395                 400


Pro Val Arg Arg Gly Asp Gln Asp Ala Trp Val Pro Arg Ala Asp Leu 
                405                 410                 415


Thr Cys Gly Cys Leu Arg Leu Gln Pro Gly Thr Asp Tyr Leu Leu Leu 
            420                 425                 430


Gly Ser Ala Val Gly Asp Pro Asp Pro Thr Arg Leu Ile Leu Asp Arg 
        435                 440                 445


His Gly Leu Ala Leu Pro Trp Arg Pro Arg Trp Ala Arg Pro Leu Lys 
    450                 455                 460


Arg Leu Gln Gln Glu Glu Arg Ala Gly Gly Cys Arg Gly Val Arg Ala 
465                 470                 475                 480


Pro Thr Pro Ser Pro Arg Pro Glu His 
                485


<210>  1184
<211>  1396
<212>  DNA
<213>  Homo sapiens

<400>  1184
tttttttttt ttgtaaagat agggtctcac tttttttgct caagctggtc ttgaacttgg     60

gctcaagtga tcctcccatc tcagcctccc aaagtgccag gattacaggc acaagccgct    120

gtgctcagcg aggtgcagta acttgactga agtcacaagg tgctggtgag gctgggactt    180

ccagcaggaa ctcagcctca ggtggaaaga ccccagggtc tgtgctctga ggcctctccc    240

atgcactgtg gtgctcagga cagaggcttg gatggattga gtgagtgaat gaatgacttt    300

ggcagggggt gggtgaagag actcctgtcc ccccagccct gcctcctgac catgtcctct    360

ctcctcccca cagccgtcaa gggattctgg gccacccgcc cttccttctc caccttctac    420

ttcgtctttg ccatttttgt ggtgtccacc atctttcact gccaccagca cctggctctg    480

gtgcctgcgc cctgggcata ctcagcccgt gtggtcctgg cccccagaca cctgccccgg    540

gaggacctgt tcactatcaa ctccaagggc cgcctgggga accagatggg cgagtacgcc    600

acgctgtacg ccctggccaa gatgaacggg cggcccgcct tcatcccggc ccagatgcac    660

agcaccctgg cccccatctt cagaatcacc ctgccggtgc tgcacagcgc cacggccagc    720

aggatcccct ggcagaacta ccacctgaac gactggatgg aggaggagta ccgccacatc    780

ccggggcgct gtgtccgcct cacgggctac ccctgctcct ggaccttcta ccaccacctc    840

cgccaggaga tcctccagga gttcaccctg cacgaccacg tgcgcgagga ggcccagaag    900

ttcctgcggg gcctgcaggc caagtgggca gggcaggcga ccttcgtggg ggtccacgtg    960

cgccgggggg actatgtccg tgtcatgccg cgcgtatgga agggggtgct ggccgaccgg   1020

ctacctgcag cgggccctgg actggttccg ggcctgctgc cgcctcccgg tctttgtggt   1080

caccagcgat gacatggcct ggtgccggga gagcatcaac agctcccttg gggacgtggt   1140

gttcgctggc aatggcctcc agggctcacc tgccaaggac ttcgcactgc tcacacagtg   1200

caaccacacc atcatcaccg tgggcacctt cggggtctgg gccgcgtacc tcgcgggcgg   1260

ggacactgtc tacctggcca acttcaccct gcccaactcc cctttcaacg tggtctttag   1320

gccgtaagcg gccttcctgc cagagtgggt gggccttgcg gctgaccttg gacaggctgg   1380

acagaacggc ctctag                                                   1396


<210>  1185
<211>  3115
<212>  DNA
<213>  Homo sapiens

<400>  1185
agtcaccgat gctggaaggg tttctttggc cctgagtgaa gagagaccca gagggaacac     60

tgaggtgcct gcccaaccac tctgtcccgg tttccttcag caggaccagg tgagagaagc    120

catgctggtc gttcagatgc ctttctcctt tcccatggcc cacttcatcc tctttgtctt    180

tacggtttcc actatatttc acgttcagca gcggctagcg aagattcaag ccatgtggga    240

gttaccggtg cagataccag tgctagcctc aacatcaaag gcactgggac ccagccagct    300

cagggggatg tggacgatca atgcaatagg ccgcctgggg aaccagatgg gcgagtacgc    360

cacactgtac gccctggcca agatgaacgg gcggcccgcc ttcatcccgg cccagatgca    420

cagcaccctg gcccccatct tcagaatcac cctgccggtg ctgcacagcg ccacggccag    480

caggatcccc tggcagaact accacctgaa cgactggatg gaggaggaat accgccacat    540

cccgggggag tacgtccgct tcaccggcta cccctgctcc tggaccttct accaccacct    600

ccgccaggag atcctccagg agttcaccct gcacgaccac gtgcgggagg aggcccagaa    660

gttcctgcgg ggcctgcagg tgaacgggag ccggccgggc acctttgtag gggtccatgt    720

tcgccgaggg gactatgtcc atgtcatgcc aaaagtgtgg aagggggtgg tggccgaccg    780

gcgataccta cagcaggccc tggactggtt ccgagctcgc tacagctccc tcatcttcgt    840

ggtcaccagt aatggcatgg cctggtgtcg ggagaacatt gacacctccc acggtgatgt    900

ggtgtttgct ggcgatggca ttgagggctc acctgccaaa gattttgctc tactcacaca    960

gtgtaaccac accatcatga ccattgggac gttcgggatc tgggccgcat acctcacggg   1020

cggagacacc atctacctgg ccaattacac cctccccgac tcccctttcc tcaaaatctt   1080

taagccagag gcagccttcc tgccggagtg gacagggatt gccgcagacc tgtccccctt   1140

actcaagcac taatgctggc ccattctttg agaccttttc tccttctctg cctccctcaa   1200

gatgagtgcc cgggcatgag aagcacatgg ttccatgagc aggacccatc tctcttctgt   1260

gaagatgcgt tgggctgcaa gtaacagaaa tctcagtgaa cagtggcctg gcgtggtggc   1320

tcatgcctgt aatgctcgca ctttgtgagg ccagggtggg tggatcactt gaggtcagga   1380

gttcaagact agcctggcca acatggtgaa accccatctc gactaaaaat acaaaaatta   1440

gccaggcgtg gtggtgcaca cctgtaatcc cagctactcg ggaggctgag gcaagagaat   1500

cacttgaacc caggaggcgg aggttgcagt gagccaagat ggtgccgctg cactccagtc   1560

tgggtgacac agcaagactc catctcaaaa aaaaaaaaaa aaaaaagaaa agaaaaagaa   1620

atgaatgggt tcaaagacca taatcatgca tatcacataa gaccagaagt ggcccaggtc   1680

cagggtcagt taatttagcg gctccacaaa gtcatcagtc acctgagctc catccatctt   1740

cacatgctgt gctaccattt cttagctgta tcatcccatg gtcccaaaag ggctgctaca   1800

catccagcca tcacatgcag ataattcctt tcaaaaacag cagaaagagg ctcgttcttg   1860

tcttggtccc ttttgaagaa tgaatgaaac cttcctaagc cttccagcaa tttcccccca   1920

actccgatgg gtaggaattg tcacataccc atgtgacccg ataggaggca aaagaaatga   1980

gacttctggg attagtttag cctcagattc tgcagctgag aagttgatca gccacctctg   2040

aaggacatgc agcttgcaga aaattagggt ggtgttacca aggtgaaaag gggaaatggc   2100

tttagagtag acaacagaga tgccctgagg ggttgtgtag gttgttcact gcaggaagtc   2160

ccctggttaa gaaggcaagt ggggtttaaa cagacccaca gtctactcat caaaccaggt   2220

gtccttggca ttgtgtccac ccagagagct cactgttttc ttttcttttt cttttctttt   2280

tttttttttt tttgagatgg agtcttgctg catcccccag gctggagtgc agtggcatga   2340

tcttggctca ctgcagcctc cgcctcccag gttcaagcga ttctcctgcc tcagcctccc   2400

gagtagctag gattacaggt gcgtgccacc acgcccagct aatttttata tgtttagtgg   2460

aaatggagtt tcaccatgtt ggtcaggctg gtctcaaact cctgacctca tgatccgcct   2520

tcctcggcct cccaaagtgc tgggattaca ggtgttagcc actgcgcccg gccctagagc   2580

tcactgtttt ctagttagtc catctggaag tggagccttt ttccagtttg cacaaatgtg   2640

ccatattggc ttgtagctgg catgcatcca agtccatagg tcctgcctct tcaatcctgg   2700

ctttctaggg cctgggatga tcattgctag aactgagaga ccagcctggc tcagtgaact   2760

tcagggcgtt ccgttcattc tttcagtaaa tgtttgcagc acatgtgtta catgtcaggc   2820

agtgaaaccc cccacagcag ccttccctct cagaggatac atttgtaacc attacacagt   2880

catcaaagga ataatttttt ttaatcacca gtgtgcatac agtcatggag ttgggtattc   2940

ccagctacca gggaggctga ggtgggagga ttgcttgatg ccaggagtta gggaatatag   3000

tgcaccgtga ttggacttgc gaatagccac tgcactgcgg cctggacgac gtagtgatac   3060

cctgactctt ataaataaat aaatgaataa acacaattat gactttgcgg atggg        3115


<210>  1186
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  1186

Met Leu Val Val Gln Met Pro Phe Ser Phe Pro Met Ala His Phe Ile 
1               5                   10                  15


Leu Phe Val Phe Thr Val Ser Thr Ile Phe His Val Gln Gln Arg Leu 
            20                  25                  30


Ala Lys Ile Gln Ala Met Trp Glu Leu Pro Val Gln Ile Pro Val Leu 
        35                  40                  45


Ala Ser Thr Ser Lys Ala Leu Gly Pro Ser Gln Leu Arg Gly Met Trp 
    50                  55                  60


Thr Ile Asn Ala Ile Gly Arg Leu Gly Asn Gln Met Gly Glu Tyr Ala 
65                  70                  75                  80


Thr Leu Tyr Ala Leu Ala Lys Met Asn Gly Arg Pro Ala Phe Ile Pro 
                85                  90                  95


Ala Gln Met His Ser Thr Leu Ala Pro Ile Phe Arg Ile Thr Leu Pro 
            100                 105                 110


Val Leu His Ser Ala Thr Ala Ser Arg Ile Pro Trp Gln Asn Tyr His 
        115                 120                 125


Leu Asn Asp Trp Met Glu Glu Glu Tyr Arg His Ile Pro Gly Glu Tyr 
    130                 135                 140


Val Arg Phe Thr Gly Tyr Pro Cys Ser Trp Thr Phe Tyr His His Leu 
145                 150                 155                 160


Arg Gln Glu Ile Leu Gln Glu Phe Thr Leu His Asp His Val Arg Glu 
                165                 170                 175


Glu Ala Gln Lys Phe Leu Arg Gly Leu Gln Val Asn Gly Ser Arg Pro 
            180                 185                 190


Gly Thr Phe Val Gly Val His Val Arg Arg Gly Asp Tyr Val His Val 
        195                 200                 205


Met Pro Lys Val Trp Lys Gly Val Val Ala Asp Arg Arg Tyr Leu Gln 
    210                 215                 220


Gln Ala Leu Asp Trp Phe Arg Ala Arg Tyr Ser Ser Leu Ile Phe Val 
225                 230                 235                 240


Val Thr Ser Asn Gly Met Ala Trp Cys Arg Glu Asn Ile Asp Thr Ser 
                245                 250                 255


His Gly Asp Val Val Phe Ala Gly Asp Gly Ile Glu Gly Ser Pro Ala 
            260                 265                 270


Lys Asp Phe Ala Leu Leu Thr Gln Cys Asn His Thr Ile Met Thr Ile 
        275                 280                 285


Gly Thr Phe Gly Ile Trp Ala Ala Tyr Leu Thr Gly Gly Asp Thr Ile 
    290                 295                 300


Tyr Leu Ala Asn Tyr Thr Leu Pro Asp Ser Pro Phe Leu Lys Ile Phe 
305                 310                 315                 320


Lys Pro Glu Ala Ala Phe Leu Pro Glu Trp Thr Gly Ile Ala Ala Asp 
                325                 330                 335


Leu Ser Pro Leu Leu Lys His 
            340


<210>  1187
<211>  1825
<212>  DNA
<213>  Homo sapiens

<400>  1187
gaatggcgct ggcccgcggc gctgcgctgg cagggagcag gcgggaggcc cgaggaaggg     60

agcctgctgc ccgcccaccc gcctgcacag gctgtgtaag ggggctgggc acgcatatcc    120

cgccaacaac tgcagctccc accagcctgc caggccaggc tcctggacac tcccttcccg    180

ccttcctcct cccacctccc tcctccctcc acagtcctcc agcttcggat ccacagacgg    240

aatcaggagc agaatccagt tcaggcgccc atctcccagc aatcaagtct tgctccctgg    300

cctgccctcc ggcaccctgg agccccgctt cccacacagc cttgctcctc ccggcctggc    360

ttgctgcctg caggcctctc agggtccttc accgtctctc cagtctcgga tccggacccg    420

tggatctcag cctcagaccc tcctctggcc ccggccttgc cctcgggcac ggcccctttc    480

ctcttcagcc ctggggtcct gctccccgag ccagaatatt gtcctccttg gaggtcccca    540

aagaaggagt ctcccaagat ctcccaacgt tggagggagt ccaagcccag ggggaacttg    600

acataccacc agtacatgcc cccagagccg agacagggat ccagggcaga cccccaagcc    660

gaggggtccg ccctgggtcc tcctgggcca tctctgtggg aagggacaga ctcgcagcag    720

ccacatccta ggatgaagcc ctctcccctc actccctgcc caccaggagt ccctagcccc    780

tcgccacccc cacacaagtt ggaacttcag acccttaaac tggaggagct gacggtctca    840

gagctccggc agcagctgcg cctgcggggc ctcccagtgt cggggaccaa gtctatgctc    900

ctggagcgca tgcgcggcgg cgcgccgccc cgcgagcggc cgaagccgcg gcgcgaggac    960

agtcccgcgg gtgctccctg gccgcgcctc aagcccaagg ccctggcagc cgcccggcgt   1020

cagggctcgg tcaagcccag cgcagcatct cacaggccac ctcttccacg cgccgcggat   1080

accccgggga cggctccggc tccaactccc actccggctc ctgctgcagc tccagccctg   1140

accccttcct cagggccggg ctcagcggct ctgactctgg aggaggagct gcaggaagcg   1200

atccggaggg cgcagttgct tcctaaccgg ggcatcgatg acatcctgga ggatcaggtg   1260

gagcctgatg accccctgcc ccctattccc ctggacttcc ctggctcctt cgacgtgctg   1320

tccccctccc cggactctga aggcctctca tctgttttct cctcttcact cccgtctccc   1380

acgaactcct cctccccttc tcccagggac cccacggact ccctggactg gctggaggcc   1440

ctgagcgggg gtcctcctct gggttctggt cccccacccc ccagcatttt ttccgctgac   1500

ttatctgact ccagcagcag ccggctgtgg gacctgctgg aggatccatg gtgatggatt   1560

ttaggattta cagagacaga gaactgatgg gggtggagag aagctccttg tgggaggaga   1620

gggaactacc agcagagccc ctcctaccgc agacacagga tcggagacaa cctccaaccc   1680

cacctgcctc ctgaagtgct gctgacatgc aactgcctta actttgccta cctggcctcc   1740

ttatgatccc cctccggcgt ggtatggttg gggggcttct tttgctgctg gccacggcaa   1800

acaagctgct tgctgcttcc ttcag                                         1825


<210>  1188
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  1188

Met Pro Pro Glu Pro Arg Gln Gly Ser Arg Ala Asp Pro Gln Ala Glu 
1               5                   10                  15


Gly Ser Ala Leu Gly Pro Pro Gly Pro Ser Leu Trp Glu Gly Thr Asp 
            20                  25                  30


Ser Gln Gln Pro His Pro Arg Met Lys Pro Ser Pro Leu Thr Pro Cys 
        35                  40                  45


Pro Pro Gly Val Pro Ser Pro Ser Pro Pro Pro His Lys Leu Glu Leu 
    50                  55                  60


Gln Thr Leu Lys Leu Glu Glu Leu Thr Val Ser Glu Leu Arg Gln Gln 
65                  70                  75                  80


Leu Arg Leu Arg Gly Leu Pro Val Ser Gly Thr Lys Ser Met Leu Leu 
                85                  90                  95


Glu Arg Met Arg Gly Gly Ala Pro Pro Arg Glu Arg Pro Lys Pro Arg 
            100                 105                 110


Arg Glu Asp Ser Pro Ala Gly Ala Pro Trp Pro Arg Leu Lys Pro Lys 
        115                 120                 125


Ala Leu Ala Ala Ala Arg Arg Gln Gly Ser Val Lys Pro Ser Ala Ala 
    130                 135                 140


Ser His Arg Pro Pro Leu Pro Arg Ala Ala Asp Thr Pro Gly Thr Ala 
145                 150                 155                 160


Pro Ala Pro Thr Pro Thr Pro Ala Pro Ala Ala Ala Pro Ala Leu Thr 
                165                 170                 175


Pro Ser Ser Gly Pro Gly Ser Ala Ala Leu Thr Leu Glu Glu Glu Leu 
            180                 185                 190


Gln Glu Ala Ile Arg Arg Ala Gln Leu Leu Pro Asn Arg Gly Ile Asp 
        195                 200                 205


Asp Ile Leu Glu Asp Gln Val Glu Pro Asp Asp Pro Leu Pro Pro Ile 
    210                 215                 220


Pro Leu Asp Phe Pro Gly Ser Phe Asp Val Leu Ser Pro Ser Pro Asp 
225                 230                 235                 240


Ser Glu Gly Leu Ser Ser Val Phe Ser Ser Ser Leu Pro Ser Pro Thr 
                245                 250                 255


Asn Ser Ser Ser Pro Ser Pro Arg Asp Pro Thr Asp Ser Leu Asp Trp 
            260                 265                 270


Leu Glu Ala Leu Ser Gly Gly Pro Pro Leu Gly Ser Gly Pro Pro Pro 
        275                 280                 285


Pro Ser Ile Phe Ser Ala Asp Leu Ser Asp Ser Ser Ser Ser Arg Leu 
    290                 295                 300


Trp Asp Leu Leu Glu Asp Pro Trp 
305                 310


<210>  1189
<211>  3311
<212>  DNA
<213>  Homo sapiens

<400>  1189
caaccctacc cagatctcct cccccaggcc tggtctcctc acaggacgcc ccctccccgc     60

tcttcctgcc gggtttcctc ttgccttttc ctgtccccca cccagtgctg ggagccgtgg    120

cagaggcaag agcagtggaa ctgacccagg ccagtggagc cagggcctcc gggtgtgccg    180

gacccgaagc aggggccatg ctgtctggtg aacggaagga gggcggaagc ccccgcttcg    240

ggaagcttca tctccccgtg ggcctgtgga tcaattcccc caggaagcag ctggcgaagc    300

tggggcggcg ctggcccagc gcagcctctg tcaagtcttc ttcgtcggac acggggagcc    360

gcagcagcga gccgctacct ccgcccccgc cgcacgtgga gctgcggcga gtgggcgctg    420

tcaaggcggc cgggggagcc tccggtagcc gcgccaagcg catctcccag ctcttccggg    480

gctcggggac cgggaccacg gggtccagcg gcgcaggagg ccctgggacc ccggggggcg    540

cgcagcgctg ggccagcgag aagaagctgc cggagctggc ggcgggcgtg gcccccgagc    600

ccccgctggc tacccgcgcc acggcgcctc cgggggtcct caagatcttc ggcgccggac    660

tggcatcggg cgccaactac aagagcgtgc tggccacggc gcgctccacg gcgcgcgagc    720

tcgtggccga ggcgctagag cgctacggcc tagcaggcag ccccggcggt ggccccggcg    780

agagcagctg cgtggacgcc ttcgctttgt gcgacgctct gggccggccc gcggcggcgg    840

gcgtgggaag cggcgagtgg cgggcggagc acctgcgcgt gctgggcgac tccgagcgcc    900

cgctgctggt gcaggagctg tggcgggcgc ggcccggctg ggcgcggcgc ttcgagttgc    960

gcggccgcga ggaggcgcgg cgcctggagc aggaggcctt cggggccgcg gacagcgaag   1020

gcaccggcgc cccttcgtgg cggccacaga agaaccgctc ccgggcggcg tcgggtgggg   1080

cagcgctggc cagtcctggc ccggggaccg gatcaggggc cccagctggg tctggaggca   1140

aggagcgctc agaaaacttg tctttgcggc gcagcgtgtc ggagcttagc cttcaggggc   1200

ggcggcggcg gcagcaggag cggagacagc aggcacttag catggcccca ggggcagccg   1260

acgcccaaat cggaactgca gaccccgggg acttcgatca gttgactcag tgcctcatcc   1320

aggcccccag caaccgcccc tacttcctgc tgctccaggg ctaccaggac gcccaggact   1380

ttgtggtgta tgtgatgacg cgagagcagc acgtgtttgg gcgaggtggg aactcgtctg   1440

gccgcggggg gtccccggct ccctatgtgg acaccttcct caacgccccg gacatcctgc   1500

cgcgtcactg cacagtgcgc gcgggccctg agcacccggc catggtgcgc ccgtcccggg   1560

gcgccccagt cacgcacaac gggtgcctcc tgctgcggga ggctgagctg cacccgggcg   1620

acctcctggg gctgggcgag cacttcctgt tcatgtacaa ggacccccgc actgggggct   1680

cggggcctgc gaggccgccg tggctgcccg cgcgccccgg ggccacgccg ccaggccctg   1740

gctgggcctt ctcctgtcgc ctgtgcggcc gcggcctgca ggagcgcggc gaggcactgg   1800

ccgcctacct ggacggccgt gagccagtcc tgcgcttccg gccgcgcgag gaggaggcgc   1860

tgctgggcga gatcgtgcgc gccgcagccg ccggctcggg agacctgccg cccctcgggc   1920

ccgccacgct gctggcgctg tgcgtgcagc attccgcccg tgagctggag ctgggccacc   1980

tgccacgact gctgggccgc ctggcccggc tcatcaagga ggccgtctgg gaaaagatta   2040

aggaaattgg agaccgtcag ccagaaaacc accctgaggg ggtccccgag gtgcccctga   2100

ctcctgaagc tgtgtctgtg gagctgcggc cactcatgct gtggatggcc aacaccacgg   2160

agctgcttag ctttgtgcag gagaaggtgc tggaaatgga gaaggaggct gaccaagagg   2220

acccacagct ctgcaatgac ttggaattat gtgatgaggc catggccctc ctggatgagg   2280

tcatcatgtg taccttccag cagtctgtct actacctcac caagactctc tattcaacgc   2340

tgcctgctct cctggatagt aaccctttca cagctggtgc agagctgccg gggcctggcg   2400

cggagctggg ggccatgcct ccaggattga gacctaccct gggcgtgttc caggcagcct   2460

tggagctgac cagccagtgc gagctgcacc ctgacctcgt gtctcagact tttggctact   2520

tgttcttctt ctccaacgca tcccttctca actcgctgat ggaacgaggt caaggccggc   2580

ctttctatca atggtcccga gctgttcaaa tccgaaccaa cctggacctc gtcttggact   2640

ggctacaggg agctgggctg ggcgacattg ccactgagtt cttccggaaa ctctccatgg   2700

ctgtgaacct gctctgtgtg ccccgcactt ccctgctcaa ggcttcatgg agcagcctaa   2760

gaaccgacca ccccaccttg acccccgccc agctgcacca tctgctcagc cactatcagc   2820

tgggccctgg ccgcgggccg ccagccgcgt gggaccctcc ccctgcagag cgggaggctg   2880

tggacacagg ggacatcttc gaaagcttct cctcgcaccc gcccctcatc ctccccctgg   2940

ggagctcgcg cctgcgcctc actggtccag tgacggacga tgccttgcac cgtgaactcc   3000

gtaggctccg ccgcctcctc tgggatcttg agcagcagga gctgccagcc aattatcgcc   3060

atgggcctcc cgtggccacg tctccttgag aaccaatacc aaacgagcgc gcgaaccttg   3120

aaatgtcacg ggcttctacg gacaggagcc cgcctgagcg caaagctttc tgggagttgt   3180

agttcttatc ccgcgtggaa tgttgggaga ttgagttttc gggaagtagc ggatgggacg   3240

gtgggagcat gggcttagga tgtgaatgcc agggagcaat aaaggtatcc gtggtatcgg   3300

caaaaaaaaa a                                                        3311


<210>  1190
<211>  963
<212>  PRT
<213>  Homo sapiens

<400>  1190

Met Leu Ser Gly Glu Arg Lys Glu Gly Gly Ser Pro Arg Phe Gly Lys 
1               5                   10                  15


Leu His Leu Pro Val Gly Leu Trp Ile Asn Ser Pro Arg Lys Gln Leu 
            20                  25                  30


Ala Lys Leu Gly Arg Arg Trp Pro Ser Ala Ala Ser Val Lys Ser Ser 
        35                  40                  45


Ser Ser Asp Thr Gly Ser Arg Ser Ser Glu Pro Leu Pro Pro Pro Pro 
    50                  55                  60


Pro His Val Glu Leu Arg Arg Val Gly Ala Val Lys Ala Ala Gly Gly 
65                  70                  75                  80


Ala Ser Gly Ser Arg Ala Lys Arg Ile Ser Gln Leu Phe Arg Gly Ser 
                85                  90                  95


Gly Thr Gly Thr Thr Gly Ser Ser Gly Ala Gly Gly Pro Gly Thr Pro 
            100                 105                 110


Gly Gly Ala Gln Arg Trp Ala Ser Glu Lys Lys Leu Pro Glu Leu Ala 
        115                 120                 125


Ala Gly Val Ala Pro Glu Pro Pro Leu Ala Thr Arg Ala Thr Ala Pro 
    130                 135                 140


Pro Gly Val Leu Lys Ile Phe Gly Ala Gly Leu Ala Ser Gly Ala Asn 
145                 150                 155                 160


Tyr Lys Ser Val Leu Ala Thr Ala Arg Ser Thr Ala Arg Glu Leu Val 
                165                 170                 175


Ala Glu Ala Leu Glu Arg Tyr Gly Leu Ala Gly Ser Pro Gly Gly Gly 
            180                 185                 190


Pro Gly Glu Ser Ser Cys Val Asp Ala Phe Ala Leu Cys Asp Ala Leu 
        195                 200                 205


Gly Arg Pro Ala Ala Ala Gly Val Gly Ser Gly Glu Trp Arg Ala Glu 
    210                 215                 220


His Leu Arg Val Leu Gly Asp Ser Glu Arg Pro Leu Leu Val Gln Glu 
225                 230                 235                 240


Leu Trp Arg Ala Arg Pro Gly Trp Ala Arg Arg Phe Glu Leu Arg Gly 
                245                 250                 255


Arg Glu Glu Ala Arg Arg Leu Glu Gln Glu Ala Phe Gly Ala Ala Asp 
            260                 265                 270


Ser Glu Gly Thr Gly Ala Pro Ser Trp Arg Pro Gln Lys Asn Arg Ser 
        275                 280                 285


Arg Ala Ala Ser Gly Gly Ala Ala Leu Ala Ser Pro Gly Pro Gly Thr 
    290                 295                 300


Gly Ser Gly Ala Pro Ala Gly Ser Gly Gly Lys Glu Arg Ser Glu Asn 
305                 310                 315                 320


Leu Ser Leu Arg Arg Ser Val Ser Glu Leu Ser Leu Gln Gly Arg Arg 
                325                 330                 335


Arg Arg Gln Gln Glu Arg Arg Gln Gln Ala Leu Ser Met Ala Pro Gly 
            340                 345                 350


Ala Ala Asp Ala Gln Ile Gly Thr Ala Asp Pro Gly Asp Phe Asp Gln 
        355                 360                 365


Leu Thr Gln Cys Leu Ile Gln Ala Pro Ser Asn Arg Pro Tyr Phe Leu 
    370                 375                 380


Leu Leu Gln Gly Tyr Gln Asp Ala Gln Asp Phe Val Val Tyr Val Met 
385                 390                 395                 400


Thr Arg Glu Gln His Val Phe Gly Arg Gly Gly Asn Ser Ser Gly Arg 
                405                 410                 415


Gly Gly Ser Pro Ala Pro Tyr Val Asp Thr Phe Leu Asn Ala Pro Asp 
            420                 425                 430


Ile Leu Pro Arg His Cys Thr Val Arg Ala Gly Pro Glu His Pro Ala 
        435                 440                 445


Met Val Arg Pro Ser Arg Gly Ala Pro Val Thr His Asn Gly Cys Leu 
    450                 455                 460


Leu Leu Arg Glu Ala Glu Leu His Pro Gly Asp Leu Leu Gly Leu Gly 
465                 470                 475                 480


Glu His Phe Leu Phe Met Tyr Lys Asp Pro Arg Thr Gly Gly Ser Gly 
                485                 490                 495


Pro Ala Arg Pro Pro Trp Leu Pro Ala Arg Pro Gly Ala Thr Pro Pro 
            500                 505                 510


Gly Pro Gly Trp Ala Phe Ser Cys Arg Leu Cys Gly Arg Gly Leu Gln 
        515                 520                 525


Glu Arg Gly Glu Ala Leu Ala Ala Tyr Leu Asp Gly Arg Glu Pro Val 
    530                 535                 540


Leu Arg Phe Arg Pro Arg Glu Glu Glu Ala Leu Leu Gly Glu Ile Val 
545                 550                 555                 560


Arg Ala Ala Ala Ala Gly Ser Gly Asp Leu Pro Pro Leu Gly Pro Ala 
                565                 570                 575


Thr Leu Leu Ala Leu Cys Val Gln His Ser Ala Arg Glu Leu Glu Leu 
            580                 585                 590


Gly His Leu Pro Arg Leu Leu Gly Arg Leu Ala Arg Leu Ile Lys Glu 
        595                 600                 605


Ala Val Trp Glu Lys Ile Lys Glu Ile Gly Asp Arg Gln Pro Glu Asn 
    610                 615                 620


His Pro Glu Gly Val Pro Glu Val Pro Leu Thr Pro Glu Ala Val Ser 
625                 630                 635                 640


Val Glu Leu Arg Pro Leu Met Leu Trp Met Ala Asn Thr Thr Glu Leu 
                645                 650                 655


Leu Ser Phe Val Gln Glu Lys Val Leu Glu Met Glu Lys Glu Ala Asp 
            660                 665                 670


Gln Glu Asp Pro Gln Leu Cys Asn Asp Leu Glu Leu Cys Asp Glu Ala 
        675                 680                 685


Met Ala Leu Leu Asp Glu Val Ile Met Cys Thr Phe Gln Gln Ser Val 
    690                 695                 700


Tyr Tyr Leu Thr Lys Thr Leu Tyr Ser Thr Leu Pro Ala Leu Leu Asp 
705                 710                 715                 720


Ser Asn Pro Phe Thr Ala Gly Ala Glu Leu Pro Gly Pro Gly Ala Glu 
                725                 730                 735


Leu Gly Ala Met Pro Pro Gly Leu Arg Pro Thr Leu Gly Val Phe Gln 
            740                 745                 750


Ala Ala Leu Glu Leu Thr Ser Gln Cys Glu Leu His Pro Asp Leu Val 
        755                 760                 765


Ser Gln Thr Phe Gly Tyr Leu Phe Phe Phe Ser Asn Ala Ser Leu Leu 
    770                 775                 780


Asn Ser Leu Met Glu Arg Gly Gln Gly Arg Pro Phe Tyr Gln Trp Ser 
785                 790                 795                 800


Arg Ala Val Gln Ile Arg Thr Asn Leu Asp Leu Val Leu Asp Trp Leu 
                805                 810                 815


Gln Gly Ala Gly Leu Gly Asp Ile Ala Thr Glu Phe Phe Arg Lys Leu 
            820                 825                 830


Ser Met Ala Val Asn Leu Leu Cys Val Pro Arg Thr Ser Leu Leu Lys 
        835                 840                 845


Ala Ser Trp Ser Ser Leu Arg Thr Asp His Pro Thr Leu Thr Pro Ala 
    850                 855                 860


Gln Leu His His Leu Leu Ser His Tyr Gln Leu Gly Pro Gly Arg Gly 
865                 870                 875                 880


Pro Pro Ala Ala Trp Asp Pro Pro Pro Ala Glu Arg Glu Ala Val Asp 
                885                 890                 895


Thr Gly Asp Ile Phe Glu Ser Phe Ser Ser His Pro Pro Leu Ile Leu 
            900                 905                 910


Pro Leu Gly Ser Ser Arg Leu Arg Leu Thr Gly Pro Val Thr Asp Asp 
        915                 920                 925


Ala Leu His Arg Glu Leu Arg Arg Leu Arg Arg Leu Leu Trp Asp Leu 
    930                 935                 940


Glu Gln Gln Glu Leu Pro Ala Asn Tyr Arg His Gly Pro Pro Val Ala 
945                 950                 955                 960


Thr Ser Pro 



<210>  1191
<211>  1695
<212>  DNA
<213>  Homo sapiens

<400>  1191
ggaatatcta taaaggaatt cgggccccta cgtgagaagc tcggaggggg tggtttcagg     60

agttccttgt ggagagggga tcgtccgtga ctcagacccc gtcgaaaagc tctcgatttc    120

acgcaaccaa ccttaccctc gtccccaaca caatccttga ttttacccct gggaaaatta    180

gcgtaggtgg tcatgacccc ggcttcctct ttaaaagccc tcagaacctg gaccgggctc    240

ctcaatgaac cctagtgtta gaggccacaa atcgggaatc aaggtcgggg agcggctgtt    300

tagggtgcat cactgttcag gatgcatcgg ggctcctttt tctaagcgga agtgtgcgcc    360

ctgcaaattg gaagcccgtt agttttgggg aagggtgaac aagggccccc taggtctaga    420

ggaccgcatg gagtctcgct taagtgttag tggggtcctc agttctagaa atctgcgttc    480

tcctgctctc ggtttggggt gagagcaccc ttcctaacgg tcttcgggaa ctgtgcgcgc    540

cggctgcaat ggggccgcat tttaccctcc tgtgtgcggc gctggccggt tgcttgcttc    600

ctgccgaggg gtgtgttata tgtgacccgt ctgtcgtgct ggcgctaaag tccctggaga    660

aagattacct gcctggccac ctggatgcga agcatcacaa agccatgatg gaaagggtag    720

agaatgccgt gaaggatttc caggaactgt cgcttaatga ggatgcctat atgggggtcg    780

ttgatgaggc cacactgcaa aaggggtcct ggagtttgct gaaggatctg aaacgcatca    840

cagacagtga tgtaaaaggc gatctctttg tgaaggagct attttggatg ttgcacttgc    900

aaaaggaaac ctttgccacc tatgttgctc gattccaaaa agaggcttat tgtcccaaca    960

aatgtggtgt gatgttgcaa actctgatct ggtgcaagaa ctgcaaaaag gaggttcacg   1020

cttgtcgaaa gtcctacgat tgcggggagc ggaatgtgga agttcctcaa atggaagaca   1080

tgatcctgga ctgtgagtta aactggcatc aggcttcgga aggcctcact gattacagct   1140

tttacagggt ttgggggaac aatacggaga ccttggtgtc caaggggaaa gaggccaccc   1200

tgaccaagcc catggtgggt ccagaggatg caggcagcta ccgctgcgag ctgggctctg   1260

tgaattccag cccagccacg atcatcaatt ttcacgtcac agtgttgccc aaaatgatca   1320

aggaggaaaa accttctcca aatatcgtaa ccccggggga ggcgaccacg gagtcgtcca   1380

taagcctcca gcctctgcag cccgagaaaa tgctggcaag ccgccttctg gggctgctga   1440

tctgcggctc cctagcactg ataaccggcc ttacctttgc gatatttcgt cgaaggaagg   1500

tgatcgattt catcaaatcc tcactgtttg gccttggcag tggagttgcc gagcaaaccc   1560

aggtcccaaa agaaaaggcc acagattcga ggcaacaata aagatttatc ttgttgtcta   1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1680

aaaaaaaaaa aaaaa                                                    1695


<210>  1192
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  1192

Met Gly Pro His Phe Thr Leu Leu Cys Ala Ala Leu Ala Gly Cys Leu 
1               5                   10                  15


Leu Pro Ala Glu Gly Cys Val Ile Cys Asp Pro Ser Val Val Leu Ala 
            20                  25                  30


Leu Lys Ser Leu Glu Lys Asp Tyr Leu Pro Gly His Leu Asp Ala Lys 
        35                  40                  45


His His Lys Ala Met Met Glu Arg Val Glu Asn Ala Val Lys Asp Phe 
    50                  55                  60


Gln Glu Leu Ser Leu Asn Glu Asp Ala Tyr Met Gly Val Val Asp Glu 
65                  70                  75                  80


Ala Thr Leu Gln Lys Gly Ser Trp Ser Leu Leu Lys Asp Leu Lys Arg 
                85                  90                  95


Ile Thr Asp Ser Asp Val Lys Gly Asp Leu Phe Val Lys Glu Leu Phe 
            100                 105                 110


Trp Met Leu His Leu Gln Lys Glu Thr Phe Ala Thr Tyr Val Ala Arg 
        115                 120                 125


Phe Gln Lys Glu Ala Tyr Cys Pro Asn Lys Cys Gly Val Met Leu Gln 
    130                 135                 140


Thr Leu Ile Trp Cys Lys Asn Cys Lys Lys Glu Val His Ala Cys Arg 
145                 150                 155                 160


Lys Ser Tyr Asp Cys Gly Glu Arg Asn Val Glu Val Pro Gln Met Glu 
                165                 170                 175


Asp Met Ile Leu Asp Cys Glu Leu Asn Trp His Gln Ala Ser Glu Gly 
            180                 185                 190


Leu Thr Asp Tyr Ser Phe Tyr Arg Val Trp Gly Asn Asn Thr Glu Thr 
        195                 200                 205


Leu Val Ser Lys Gly Lys Glu Ala Thr Leu Thr Lys Pro Met Val Gly 
    210                 215                 220


Pro Glu Asp Ala Gly Ser Tyr Arg Cys Glu Leu Gly Ser Val Asn Ser 
225                 230                 235                 240


Ser Pro Ala Thr Ile Ile Asn Phe His Val Thr Val Leu Pro Lys Met 
                245                 250                 255


Ile Lys Glu Glu Lys Pro Ser Pro Asn Ile Val Thr Pro Gly Glu Ala 
            260                 265                 270


Thr Thr Glu Ser Ser Ile Ser Leu Gln Pro Leu Gln Pro Glu Lys Met 
        275                 280                 285


Leu Ala Ser Arg Leu Leu Gly Leu Leu Ile Cys Gly Ser Leu Ala Leu 
    290                 295                 300


Ile Thr Gly Leu Thr Phe Ala Ile Phe Arg Arg Arg Lys Val Ile Asp 
305                 310                 315                 320


Phe Ile Lys Ser Ser Leu Phe Gly Leu Gly Ser Gly Val Ala Glu Gln 
                325                 330                 335


Thr Gln Val Pro Lys Glu Lys Ala Thr Asp Ser Arg Gln Gln 
            340                 345                 350


<210>  1193
<211>  4244
<212>  DNA
<213>  Homo sapiens

<400>  1193
gaaagtccct gactggagtt ggcagccaag ccaggccctg gagtgggcac ccagagggaa     60

gacaggttgg ctaatttcct ggagccccta agggtgcaag ggggaagaac acccacccgc    120

aaagccccgt agctggaccc tacgttagcc tgccctgctc ggggttggcg atgctggagg    180

tgggccttgg accagagaaa atgctttaat taggtgacaa gcgggcagag gcctttgtct    240

ctggagccgg cagccacggc ccccgctgac ggcgtgggaa acagaccctg ttccactccg    300

gtctccagcc ttggaatggt tgccttcgtg cagtgcagga ggacgcggca gagggcggac    360

gatcgctcca ctcgccggga ccaggtgcgg gggccctgcc cagccgctgg ggcgtggcca    420

ggctcgaagc acccaggtgt cgggggccga ctctaagccc tggcaccgga agagagaggg    480

cggcggattg gacctcccgg ctccagcatt gcaactgggc gctccgtctc ctggtccacg    540

caatgatggt gcggctgctc agaagccagg tagcctgccc tgggtgaagc cttcgcgcag    600

gtcaatgacg gggcggaggg gcagggcgcg gtcccctgca tccccgatct ggggagcggt    660

gggcccaggg gccatcgcct tagcccctgg cgctggggct cggcgccaag tgacgggcgg    720

ggctccacct tccagccatc cgcccggccc gggagggcgg acgctgcgag actcccggcc    780

gcgccctctc cttcctctcc tccccaagcc ctcgctgcca gtccggacag gctgcgcgga    840

ggggagggct gccgggccgg atagccggac gcctggcgtt ccaggggcgg ccggatgtgg    900

cctgcctttg cggagggtgc gctccggcca cgaaaagcgg actgtggatc tgccacctgc    960

aagcagctcg gccatgtggc tccggagcca tcgtcagctc tgcctggcct tcctgctagt   1020

ctgtgtcctc tctgtaatct tcttcctcca tatccatcaa gacagctttc cacatggcct   1080

aggcctgtcg atcctgtgtc cagaccgccg cctggtgaca cccccagtgg ccatcttctg   1140

cctgccgggt actgcgatgg gccccaacgc ctcctcttcc tgtccccagc accctgcttc   1200

cctctccggc acctggactg tctaccccaa tggccggttt ggtaatcaga tgggacagta   1260

tgccacgctg ctggctctgg cccagctcaa cggccgccgg gcctttatcc tgcctgccat   1320

gcatgccgcc ctggccccgg tattccgcat caccctgccc gtgctggccc cagaagtgga   1380

cagccgcacg ccgtggcggg agctgcagct tcacgactgg atgtcggagg agtacgcgga   1440

cttgagagat cctttcctga agctctctgg cttcccctgc tcttggactt tcttccacca   1500

tctccgggaa cagatccgca gagagttcac cctgcacgac caccttcggg aagaggcgca   1560

gagtgtgctg ggtcagctcc gcctgggccg cacaggggac cgcccgcgca cctttgtcgg   1620

cgtccacgtg cgccgtgggg actatctgca ggttatgcct cagcgctgga agggtgtggt   1680

gggcgacagc gcctacctcc ggcaggccat ggactggttc cgggcacggc acgaagcccc   1740

cgttttcgtg gtcaccagca acggcatgga gtggtgtaaa gaaaacatcg acacctccca   1800

gggcgatgtg acgtttgctg gcgatggaca ggaggctaca ccgtggaaag actttgccct   1860

gctcacacag tgcaaccaca ccattatgac cattggcacc ttcggcttct gggctgccta   1920

cctggctggc ggagacactg tctacctggc caacttcacc ctgccagact ctgagttcct   1980

gaagatcttt aagccggagg cggccttcct gcccgagtgg gtgggcatta atgcagactt   2040

gtctccactc tggacattgg ctaagccttg agagccaggg agactttctg aagtagcctg   2100

atctttctag agccagcagt acgtggcttc agaggcctgg catcttctgg agaagcttgt   2160

ggtgttcctg aagcaaatgg gtgcccgtat ccagagtgat tctagttggg agagttggag   2220

agaaggggga cgtttctgga actgtctgaa tattctagaa ctagcaaaac atcttttcct   2280

gatggctggc aggcagttct agaagccaca gtgcccacct gctcttccca gcccatatct   2340

acagtacttc cagatggctg cccccaggaa tggggaactc tccctctggt ctactctaga   2400

agaggggtta cttctcccct gggtcctcca aagactgaag gagcatatga ttgctccaga   2460

gcaagcattc accaagtccc cttctgtgtt tctggagtga ttctagaggg agacttgttc   2520

tagagaggac caggtttgat gcctgtgaag aaccctgcag ggcccttatg gacaggatgg   2580

ggttctggaa atccagataa ctaaggtgaa gaatcttttt agtttttttt tttttttttt   2640

ggagacaggg tctcgctctg ttgcccaggc tggagtgcag tggcgtgatc ttggctcact   2700

gcaacttccg cctcctgtgt tcaagcgatt ctcctgtctc agcctcctga gtagatggga   2760

ctacaggcac aggccattat gcctggctaa tttttgtatt tttagtagag acagggtttc   2820

accatgttgg ccaggatggt ctcgatctcc tgaccttgtc atccacctgt cttggcctcc   2880

caaagtgctg ggattactgg catgagccac tgtgcccagc ccggatattt tttttttaat   2940

tatttattta tttatttatt tattgagacg gagtcttgct ctgtagccca ggccagagtg   3000

cagtggcgcg atctcagctc actgcaagct ctgcctcccg ggttcatgcc attctgcctc   3060

agcctcctga gtagctggga ctacaggcgc ccgccaccac gcccggctaa ttttttttgt   3120

atttttagta gagacggggt ttcatcgtgt taaccaggat ggtctcgatc tcctgacctc   3180

gtgatctgcc cacctcggcc tcccacagtg ctgggattac cggcgtgagc caccatgcct   3240

ggcccggata atttttttta atttttgtag agacgaggtc ttgtgatatt gcccaggctg   3300

ttcttcaact cctgggctca agcagtcctc ccaccttggc ctcccagaat gctgggttta   3360

tagatgtgag ccagcacacc gggccaagtg aagaatctaa tgaatgtgca acctaattgt   3420

agcatctaat gaatgttcca ccattgctgg aaaaattgag atggaaaaca aaccatctct   3480

agttggccag cgtcttgctc tgttcacagt ctctggaaaa gctggggtag ttggtgagca   3540

gagcgggact ctgtccaaca agccccacag cccctcaaag actttttttt gtttgttttg   3600

agcagacagg ctaaaatgtg aacgtggggt gagggatcac tgccaaaatg gtacagcttc   3660

tggagcagaa ctttccaggg atccagggac actttttttt aaagctcata aactgccaag   3720

agctccatat attgggtgtg agttcaggtt gcctctcaca atgaaggaag ttggtctttg   3780

tctgcaggtg ggctgctgag ggtctgggat ctgttttctg gaagtgtgca ggtataaaca   3840

caccctctgt gcttgtgaca aactggcagg taccgtgctc attgctaacc actgtctgtc   3900

cctgaactcc cagaaccact acatctggct ttgggcaggt ctgagataaa acgatctaaa   3960

ggtaggcaga ccctggaccc agcctcagat ccaggcagga gcacgaggtc tggccaaggt   4020

ggacggggtt gtcgagatct caggagcccc ttgctgtttt ttggagggtg aaagaagaaa   4080

ccttaaacat agtcagctct gatcacatcc cctgtctact catccagacc ccatgcctgt   4140

aggcttatca gggagttaca gttacaattg ttacagtact gttcccaact cagctgccac   4200

gggtgagaga gcaggaggta tgaattaaaa gtctacagca ctaa                    4244


<210>  1194
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  1194

Met Trp Leu Arg Ser His Arg Gln Leu Cys Leu Ala Phe Leu Leu Val 
1               5                   10                  15


Cys Val Leu Ser Val Ile Phe Phe Leu His Ile His Gln Asp Ser Phe 
            20                  25                  30


Pro His Gly Leu Gly Leu Ser Ile Leu Cys Pro Asp Arg Arg Leu Val 
        35                  40                  45


Thr Pro Pro Val Ala Ile Phe Cys Leu Pro Gly Thr Ala Met Gly Pro 
    50                  55                  60


Asn Ala Ser Ser Ser Cys Pro Gln His Pro Ala Ser Leu Ser Gly Thr 
65                  70                  75                  80


Trp Thr Val Tyr Pro Asn Gly Arg Phe Gly Asn Gln Met Gly Gln Tyr 
                85                  90                  95


Ala Thr Leu Leu Ala Leu Ala Gln Leu Asn Gly Arg Arg Ala Phe Ile 
            100                 105                 110


Leu Pro Ala Met His Ala Ala Leu Ala Pro Val Phe Arg Ile Thr Leu 
        115                 120                 125


Pro Val Leu Ala Pro Glu Val Asp Ser Arg Thr Pro Trp Arg Glu Leu 
    130                 135                 140


Gln Leu His Asp Trp Met Ser Glu Glu Tyr Ala Asp Leu Arg Asp Pro 
145                 150                 155                 160


Phe Leu Lys Leu Ser Gly Phe Pro Cys Ser Trp Thr Phe Phe His His 
                165                 170                 175


Leu Arg Glu Gln Ile Arg Arg Glu Phe Thr Leu His Asp His Leu Arg 
            180                 185                 190


Glu Glu Ala Gln Ser Val Leu Gly Gln Leu Arg Leu Gly Arg Thr Gly 
        195                 200                 205


Asp Arg Pro Arg Thr Phe Val Gly Val His Val Arg Arg Gly Asp Tyr 
    210                 215                 220


Leu Gln Val Met Pro Gln Arg Trp Lys Gly Val Val Gly Asp Ser Ala 
225                 230                 235                 240


Tyr Leu Arg Gln Ala Met Asp Trp Phe Arg Ala Arg His Glu Ala Pro 
                245                 250                 255


Val Phe Val Val Thr Ser Asn Gly Met Glu Trp Cys Lys Glu Asn Ile 
            260                 265                 270


Asp Thr Ser Gln Gly Asp Val Thr Phe Ala Gly Asp Gly Gln Glu Ala 
        275                 280                 285


Thr Pro Trp Lys Asp Phe Ala Leu Leu Thr Gln Cys Asn His Thr Ile 
    290                 295                 300


Met Thr Ile Gly Thr Phe Gly Phe Trp Ala Ala Tyr Leu Ala Gly Gly 
305                 310                 315                 320


Asp Thr Val Tyr Leu Ala Asn Phe Thr Leu Pro Asp Ser Glu Phe Leu 
                325                 330                 335


Lys Ile Phe Lys Pro Glu Ala Ala Phe Leu Pro Glu Trp Val Gly Ile 
            340                 345                 350


Asn Ala Asp Leu Ser Pro Leu Trp Thr Leu Ala Lys Pro 
        355                 360                 365


<210>  1195
<211>  940
<212>  DNA
<213>  Homo sapiens

<400>  1195
ctgtcagctg aggatccagc cgaaagagga gccaggcact caggccacct gagtctactc     60

acctggacaa ctggaatctg gcaccaattc taaaccactc agcttctccg agctcacacc    120

ccggagatca cctgaggacc cgagccattg atggactcgg acgagaccgg gttcgagcac    180

tcaggactgt gggtttctgt gctggctggt cttctgctgg gagcctgcca ggcacacccc    240

atccctgact ccagtcctct cctgcaattc gggggccaag tccggcagcg gtacctctac    300

acagatgatg cccagcagac agaagcccac ctggagatca gggaggatgg gacggtgggg    360

ggcgctgctg accagagccc cgaaagtctc ctgcagctga aagccttgaa gccgggagtt    420

attcaaatct tgggagtcaa gacatccagg ttcctgtgcc agcggccaga tggggccctg    480

tatggatcgc tccactttga ccctgaggcc tgcagcttcc gggagctgct tcttgaggac    540

ggatacaatg tttaccagtc cgaagcccac ggcctcccgc tgcacctgcc agggaacaag    600

tccccacacc gggaccctgc accccgagga ccagctcgct tcctgccact accaggcctg    660

ccccccgcac tcccggagcc acccggaatc ctggcccccc agccccccga tgtgggctcc    720

tcggaccctc tgagcatggt gggaccttcc cagggccgaa gccccagcta cgcttcctga    780

agccagaggc tgtttactat gacatctcct ctttatttat taggttattt atcttattta    840

tttttttatt tttcttactt gagataataa agagttccag aggagaaaaa aaaaaaaaaa    900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                          940


<210>  1196
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  1196

Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser 
1               5                   10                  15


Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro 
            20                  25                  30


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        35                  40                  45


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
    50                  55                  60


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
65                  70                  75                  80


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                85                  90                  95


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
            100                 105                 110


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        115                 120                 125


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
    130                 135                 140


His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly 
145                 150                 155                 160


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu 
                165                 170                 175


Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp 
            180                 185                 190


Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
        195                 200                 205


Ser 



<210>  1197
<211>  2722
<212>  DNA
<213>  Homo sapiens

<400>  1197
cacagcagcc cccgcgcccg ccgtgccgcc gccgggacgt ggggcccttg ggccgtcggg     60

ccgcctgggg agcgccagcc cggatccggc tgcccagatg cgggcgccac tctgcctgct    120

cctgctcgtc gcccacgccg tggacatgct cgccctgaac cgaaggaaga agcaagtggg    180

cactggcctg gggggcaact gcacaggctg tatcatctgc tcagaggaga acggctgttc    240

cacctgccag cagaggctct tcctgttcat ccgccgggaa ggcatccgcc agtacggcaa    300

gtgcctgcac gactgtcccc ctgggtactt cggcatccgc ggccaggagg tcaacaggtg    360

caaaaaatgt ggggccactt gtgagagctg cttcagccag gacttctgca tccggtgcaa    420

gaggcagttt tacttgtaca aggggaagtg tctgcccacc tgcccgccgg gcactttggc    480

ccaccagaac acacgggagt gccaggggga gtgtgaactg ggtccctggg gcggctggag    540

cccctgcaca cacaatggaa agacctgcgg ctcggcttgg ggcctggaga gccgggtacg    600

agaggctggc cgggctgggc atgaggaggc agccacctgc caggtgcttt ctgagtcaag    660

gaaatgtccc atccagaggc cctgcccagg agagaggagc cccggccaga agaagggcag    720

gaaggaccgg cgcccacgca aggacaggaa gctggaccgc aggctggacg tgaggccgcg    780

ccagcccggc ctgcagccct gaccgccggc tctcccgact ctctggtcct agtcctcggc    840

ccctgcacac ctcctcctgc tccttctcct cctctcctct tactctttct cctctgtctt    900

ctccatttgt cctctctttc tttccaccct tctatcattt ttctgtcagt ctaccttccc    960

tttctttttc ttttttattt cctttatttc ttccacctcc attctcctct cctttctccc   1020

tccctccttc ccttccttcc tcttctttct cacttatctt ttatctttcc ttttctttct   1080

tcctgtgttt cttcctgtcc ttcaccgcat ccttctctct ctccctcctc ttgtctccct   1140

ctcacacaca ctttaagagg gaccatgagc ctgtgccctc ccctgcagct ttctctatct   1200

acaacttaaa gaaagcaaac atcttttccc aggcctttcc ctgaccccat ctttgcagag   1260

aaagggtttc cagagggcaa agctgggaca cagcacaggt gaatcctgaa ggccctgctt   1320

ctgctctggg ggaggctcca ggaccctgag ctgtgagcac ctggttctct ggacagtccc   1380

cagaggccat ttccacagcc ttcagccacc agccaccccg aggagctggc tggacaaggc   1440

tccagggctt ccagaggcct ggcttggaca cctcccccag ctggccgtgg agggtcacaa   1500

cctggcctct gggtgggcag ccagccctgg agggcatcct ctgcaagctg cctgccaccc   1560

tcatcggcac tcccccacag gcctccctct catgggttcc atgccccttt ttcccaagcc   1620

ggatcaggtg agctgtcact gctgggggat ccacctgccc agcccagaag aggccactga   1680

aacggaaagg aaagctgaga ttatccagca gctctgttcc ccacctcagc gcttcctgcc   1740

catgtgggga aacaggtctg agaaggaagg ggcttgccca gggtcacaca ggaagccttc   1800

aggctctgct tctgcctgat ggctctgctc agcacattca cggtggagag gagaatttgg   1860

gggtcacttg aggggggaaa tgtagggaat tgtgggtggg gagcaaggga agatccgtgc   1920

actcgtccac acccaccacc acactcgctg acacccaccc ccacacgctg acacccaccc   1980

ccacacttgc ccacacccat caccgcactc gcccacaccc accaccacac tgccccacac   2040

ccaccaccac actcccccac acccaccacc acactcgccc acacccacca ccagtgactt   2100

gagcatctgt gcttcgctgt gacgcccctc gccctaggca ggaacgacgc tgggaggagt   2160

ctccaggtca gacccagctt ggaagcaagt ctgtcctcac tgcctatcct tctgccatca   2220

taacaccccc ttcctgctct gctccccgga atcctcagaa acgggatttg tatttgccgt   2280

gactggttgg cctgaacacg tagggctccg tgactgggac aggaatgggc aggagaagca   2340

agagtcggag ctccaagggg cccaggggtg gcctggggaa ggaagatggt cagcaggctg   2400

ggggagaggc tctaggtgat gaaatattac attcccgacc ccaagagagc acccaccctc   2460

agacctgccc tccacctggc agctggggag ccctggcctg aacccccccc tcccagcagg   2520

cccaccctct ctctgacttc cctgctctca cctccccgag aacagctaga gccccctcct   2580

ccgcctggcc aggccaccag cttctcttct gcaaacgttt gtgcctctga aatgctccgt   2640

tgttattgtt tcaagaccct aacttttttt taaaactttc ttaataaagg gaaaagaaac   2700

ttgtaaaaaa aaaaaaaaaa aa                                            2722


<210>  1198
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  1198

Met Arg Ala Pro Leu Cys Leu Leu Leu Leu Val Ala His Ala Val Asp 
1               5                   10                  15


Met Leu Ala Leu Asn Arg Arg Lys Lys Gln Val Gly Thr Gly Leu Gly 
            20                  25                  30


Gly Asn Cys Thr Gly Cys Ile Ile Cys Ser Glu Glu Asn Gly Cys Ser 
        35                  40                  45


Thr Cys Gln Gln Arg Leu Phe Leu Phe Ile Arg Arg Glu Gly Ile Arg 
    50                  55                  60


Gln Tyr Gly Lys Cys Leu His Asp Cys Pro Pro Gly Tyr Phe Gly Ile 
65                  70                  75                  80


Arg Gly Gln Glu Val Asn Arg Cys Lys Lys Cys Gly Ala Thr Cys Glu 
                85                  90                  95


Ser Cys Phe Ser Gln Asp Phe Cys Ile Arg Cys Lys Arg Gln Phe Tyr 
            100                 105                 110


Leu Tyr Lys Gly Lys Cys Leu Pro Thr Cys Pro Pro Gly Thr Leu Ala 
        115                 120                 125


His Gln Asn Thr Arg Glu Cys Gln Gly Glu Cys Glu Leu Gly Pro Trp 
    130                 135                 140


Gly Gly Trp Ser Pro Cys Thr His Asn Gly Lys Thr Cys Gly Ser Ala 
145                 150                 155                 160


Trp Gly Leu Glu Ser Arg Val Arg Glu Ala Gly Arg Ala Gly His Glu 
                165                 170                 175


Glu Ala Ala Thr Cys Gln Val Leu Ser Glu Ser Arg Lys Cys Pro Ile 
            180                 185                 190


Gln Arg Pro Cys Pro Gly Glu Arg Ser Pro Gly Gln Lys Lys Gly Arg 
        195                 200                 205


Lys Asp Arg Arg Pro Arg Lys Asp Arg Lys Leu Asp Arg Arg Leu Asp 
    210                 215                 220


Val Arg Pro Arg Gln Pro Gly Leu Gln Pro 
225                 230


<210>  1199
<211>  2536
<212>  DNA
<213>  Homo sapiens

<400>  1199
cacagcagcc cccgcgcccg ccgtgccgcc gccgggacgt ggggcccttg ggccgtcggg     60

ccgcctgggg agcgccagcc cggatccggc tgcccagatg cgggcgccac tctgcctgct    120

cctgctcgtc gcccacgccg tggacatgct cgccctgaac cgaaggaaga agcaagtggg    180

cactggcctg gggggcaact gcacaggctg tatcatctgc tcagaggaga acggctgttc    240

cacctgccag cagaggctct tcctgttcat ccgccgggaa ggcatccgcc agtacggcaa    300

gtgcctgcac gactgtcccc ctgggtactt cggcatccgc ggccaggagg tcaacaggtg    360

caaaaaatgt ggggccactt gtgagagctg cttcagccag gacttctgca tccggtgcaa    420

gaggcagttt tacttgtaca aggggaagtg tctgcccacc tgcccgccgg gcactttggc    480

ccaccagaac acacgggagt gccaggagag gagccccggc cagaagaagg gcaggaagga    540

ccggcgccca cgcaaggaca ggaagctgga ccgcaggctg gacgtgaggc cgcgccagcc    600

cggcctgcag ccctgaccgc cggctctccc gactctctgg tcctagtcct cggcccctgc    660

acacctcctc ctgctccttc tcctcctctc ctcttactct ttctcctctg tcttctccat    720

ttgtcctctc tttctttcca cccttctatc atttttctgt cagtctacct tccctttctt    780

tttctttttt atttccttta tttcttccac ctccattctc ctctcctttc tccctccctc    840

cttcccttcc ttcctcttct ttctcactta tcttttatct ttccttttct ttcttcctgt    900

gtttcttcct gtccttcacc gcatccttct ctctctccct cctcttgtct ccctctcaca    960

cacactttaa gagggaccat gagcctgtgc cctcccctgc agctttctct atctacaact   1020

taaagaaagc aaacatcttt tcccaggcct ttccctgacc ccatctttgc agagaaaggg   1080

tttccagagg gcaaagctgg gacacagcac aggtgaatcc tgaaggccct gcttctgctc   1140

tgggggaggc tccaggaccc tgagctgtga gcacctggtt ctctggacag tccccagagg   1200

ccatttccac agccttcagc caccagccac cccgaggagc tggctggaca aggctccagg   1260

gcttccagag gcctggcttg gacacctccc ccagctggcc gtggagggtc acaacctggc   1320

ctctgggtgg gcagccagcc ctggagggca tcctctgcaa gctgcctgcc accctcatcg   1380

gcactccccc acaggcctcc ctctcatggg ttccatgccc ctttttccca agccggatca   1440

ggtgagctgt cactgctggg ggatccacct gcccagccca gaagaggcca ctgaaacgga   1500

aaggaaagct gagattatcc agcagctctg ttccccacct cagcgcttcc tgcccatgtg   1560

gggaaacagg tctgagaagg aaggggcttg cccagggtca cacaggaagc cttcaggctc   1620

tgcttctgcc tgatggctct gctcagcaca ttcacggtgg agaggagaat ttgggggtca   1680

cttgaggggg gaaatgtagg gaattgtggg tggggagcaa gggaagatcc gtgcactcgt   1740

ccacacccac caccacactc gctgacaccc acccccacac gctgacaccc acccccacac   1800

ttgcccacac ccatcaccgc actcgcccac acccaccacc acactgcccc acacccacca   1860

ccacactccc ccacacccac caccacactc gcccacaccc accaccagtg acttgagcat   1920

ctgtgcttcg ctgtgacgcc cctcgcccta ggcaggaacg acgctgggag gagtctccag   1980

gtcagaccca gcttggaagc aagtctgtcc tcactgccta tccttctgcc atcataacac   2040

ccccttcctg ctctgctccc cggaatcctc agaaacggga tttgtatttg ccgtgactgg   2100

ttggcctgaa cacgtagggc tccgtgactg ggacaggaat gggcaggaga agcaagagtc   2160

ggagctccaa ggggcccagg ggtggcctgg ggaaggaaga tggtcagcag gctgggggag   2220

aggctctagg tgatgaaata ttacattccc gaccccaaga gagcacccac cctcagacct   2280

gccctccacc tggcagctgg ggagccctgg cctgaacccc cccctcccag caggcccacc   2340

ctctctctga cttccctgct ctcacctccc cgagaacagc tagagccccc tcctccgcct   2400

ggccaggcca ccagcttctc ttctgcaaac gtttgtgcct ctgaaatgct ccgttgttat   2460

tgtttcaaga ccctaacttt tttttaaaac tttcttaata aagggaaaag aaacttgtaa   2520

aaaaaaaaaa aaaaaa                                                   2536


<210>  1200
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  1200

Met Arg Ala Pro Leu Cys Leu Leu Leu Leu Val Ala His Ala Val Asp 
1               5                   10                  15


Met Leu Ala Leu Asn Arg Arg Lys Lys Gln Val Gly Thr Gly Leu Gly 
            20                  25                  30


Gly Asn Cys Thr Gly Cys Ile Ile Cys Ser Glu Glu Asn Gly Cys Ser 
        35                  40                  45


Thr Cys Gln Gln Arg Leu Phe Leu Phe Ile Arg Arg Glu Gly Ile Arg 
    50                  55                  60


Gln Tyr Gly Lys Cys Leu His Asp Cys Pro Pro Gly Tyr Phe Gly Ile 
65                  70                  75                  80


Arg Gly Gln Glu Val Asn Arg Cys Lys Lys Cys Gly Ala Thr Cys Glu 
                85                  90                  95


Ser Cys Phe Ser Gln Asp Phe Cys Ile Arg Cys Lys Arg Gln Phe Tyr 
            100                 105                 110


Leu Tyr Lys Gly Lys Cys Leu Pro Thr Cys Pro Pro Gly Thr Leu Ala 
        115                 120                 125


His Gln Asn Thr Arg Glu Cys Gln Glu Arg Ser Pro Gly Gln Lys Lys 
    130                 135                 140


Gly Arg Lys Asp Arg Arg Pro Arg Lys Asp Arg Lys Leu Asp Arg Arg 
145                 150                 155                 160


Leu Asp Val Arg Pro Arg Gln Pro Gly Leu Gln Pro 
                165                 170


<210>  1201
<211>  1108
<212>  DNA
<213>  Homo sapiens

<400>  1201
attgaatgca gcaagggtct ggaggctgag gaccaggcag acaaacattc agagttgctg     60

gaatgcgaca gagacaggga gtcagactgg tcatgcaagg tcctgggcct gcccttgggt    120

cctggggagc cacggaaggt tgtgggtgcc agagggttgt ggtcagagcc acagtcaggg    180

gccttctgag acctgtgccc cctccccacc ctccctcccc acctccctag gccagctctg    240

gggtctcggc aggtggtccg cgacatgacc tccgagttct tctctgccca gctccgggcc    300

cagatctctg acgacaccac tcacccgatc tcctactaca agcccgagtt ctacatgccg    360

gatgacgggg gcactgctca cctgtctgtg gtcgcagagg acggcagtgc tgtgtccgcc    420

accagcacca tcaacctcta ctttggctcc aaggtgcgct ccccagtcag cgggatcctg    480

ctcaataatg aaatggatga cttcagctct accagcatca ccaacgagtt tggggtaccc    540

ccctcacctg ccaatttcat ccagccaggg aagcagccgc tctcgtccat gtgcccgacg    600

atcatggtgg gccaggacgg ccaggtccgg atggtggtgg gagctgccgg gggcacgcag    660

atcaccatgg ccactgcact ggccatcatc tacaacctct ggttcggcta tgacgtgaag    720

tgggccgtgg aggagccccg gctgcacaac cagcttctgc ccaacgtcac gacagtggag    780

agaaacattg accaggaagt gactgcagcc ctggagaccc ggcaccatca cacccagatc    840

acgtccacct tcattgctgt ggtgcaagcc atcgtccgca tggctggtgg ctgggcagct    900

gcctcggact ccaggaaagg tggggaacct gctggctact gattgctcca ggcggacaag    960

gctgacaagc aatccaggaa caaaatactc accaggacga ggaagaggac tttgggggac   1020

aggcttctcc tgtgagcagc agagcagcac aataaatgag gccactgtgc caggctccag   1080

gtggcctccc tggcctgtct ccccactc                                      1108


<210>  1202
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  1202

Met Thr Ser Glu Phe Phe Ser Ala Gln Leu Arg Ala Gln Ile Ser Asp 
1               5                   10                  15


Asp Thr Thr His Pro Ile Ser Tyr Tyr Lys Pro Glu Phe Tyr Met Pro 
            20                  25                  30


Asp Asp Gly Gly Thr Ala His Leu Ser Val Val Ala Glu Asp Gly Ser 
        35                  40                  45


Ala Val Ser Ala Thr Ser Thr Ile Asn Leu Tyr Phe Gly Ser Lys Val 
    50                  55                  60


Arg Ser Pro Val Ser Gly Ile Leu Leu Asn Asn Glu Met Asp Asp Phe 
65                  70                  75                  80


Ser Ser Thr Ser Ile Thr Asn Glu Phe Gly Val Pro Pro Ser Pro Ala 
                85                  90                  95


Asn Phe Ile Gln Pro Gly Lys Gln Pro Leu Ser Ser Met Cys Pro Thr 
            100                 105                 110


Ile Met Val Gly Gln Asp Gly Gln Val Arg Met Val Val Gly Ala Ala 
        115                 120                 125


Gly Gly Thr Gln Ile Thr Met Ala Thr Ala Leu Ala Ile Ile Tyr Asn 
    130                 135                 140


Leu Trp Phe Gly Tyr Asp Val Lys Trp Ala Val Glu Glu Pro Arg Leu 
145                 150                 155                 160


His Asn Gln Leu Leu Pro Asn Val Thr Thr Val Glu Arg Asn Ile Asp 
                165                 170                 175


Gln Glu Val Thr Ala Ala Leu Glu Thr Arg His His His Thr Gln Ile 
            180                 185                 190


Thr Ser Thr Phe Ile Ala Val Val Gln Ala Ile Val Arg Met Ala Gly 
        195                 200                 205


Gly Trp Ala Ala Ala Ser Asp Ser Arg Lys Gly Gly Glu Pro Ala Gly 
    210                 215                 220


Tyr 
225


<210>  1203
<211>  1049
<212>  DNA
<213>  Homo sapiens

<400>  1203
ctcgagagct gggctctgcg tcctcgtcca gccgccaact cggccaaagg cgaagccagc     60

agtttcttct gctgccgggc aacgcgcctt ttaaacctga gggagtgggc gcgtgagcac    120

ttaatggcgc cggtgacaga gtgagcttaa cggattaata agcgcagcca ggccagctct    180

ggggtctcgg caggtggtcc gcgacatgac ctccgagttc ttctctgccc agctccgggc    240

ccagatctct gacgacacca ctcacccgat ctcctactac aagcccgagt tctacatgcc    300

ggatgacggg ggcactgctc acctgtctgt ggtcgcagag gacggcagtg ctgtgtccgc    360

caccagcacc atcaacctct actttggctc caaggtgcgc tccccagtca gcgggatcct    420

gctcaataat gaaatggatg acttcagctc taccagcatc accaacgagt ttggggtacc    480

cccctcacct gccaatttca tccagccagg gaagcagccg ctctcgtcca tgtgcccgac    540

gatcatggtg ggccaggacg gccaggtccg gatggtggtg ggagctgccg ggggcacgca    600

gatcaccatg gccactgcac tggccatcat ctacaacctc tggttcggct atgacgtgaa    660

gtgggccgtg gaggagcccc ggctgcacaa ccagcttctg cccaacgtca cgacagtgga    720

gagaaacatt gaccaggaag tgactgcagc cctggagacc cggcaccatc acacccagat    780

cacgtccacc ttcattgctg tggtgcaagc catcgtccgc atggctggtg gctgggcagc    840

tgcctcggac tccaggaaag gtggggaacc tgctggctac tgattgctcc aggcggacaa    900

ggctgacaag caatccagga acaaaatact caccaggacg aggaagagga ctttggggga    960

caggcttctc ctgtgagcag cagagcagca caataaatga ggccactgtg ccaggctcca   1020

ggtggcctcc ctggcctgtc tccccactc                                     1049


<210>  1204
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  1204

Met Thr Ser Glu Phe Phe Ser Ala Gln Leu Arg Ala Gln Ile Ser Asp 
1               5                   10                  15


Asp Thr Thr His Pro Ile Ser Tyr Tyr Lys Pro Glu Phe Tyr Met Pro 
            20                  25                  30


Asp Asp Gly Gly Thr Ala His Leu Ser Val Val Ala Glu Asp Gly Ser 
        35                  40                  45


Ala Val Ser Ala Thr Ser Thr Ile Asn Leu Tyr Phe Gly Ser Lys Val 
    50                  55                  60


Arg Ser Pro Val Ser Gly Ile Leu Leu Asn Asn Glu Met Asp Asp Phe 
65                  70                  75                  80


Ser Ser Thr Ser Ile Thr Asn Glu Phe Gly Val Pro Pro Ser Pro Ala 
                85                  90                  95


Asn Phe Ile Gln Pro Gly Lys Gln Pro Leu Ser Ser Met Cys Pro Thr 
            100                 105                 110


Ile Met Val Gly Gln Asp Gly Gln Val Arg Met Val Val Gly Ala Ala 
        115                 120                 125


Gly Gly Thr Gln Ile Thr Met Ala Thr Ala Leu Ala Ile Ile Tyr Asn 
    130                 135                 140


Leu Trp Phe Gly Tyr Asp Val Lys Trp Ala Val Glu Glu Pro Arg Leu 
145                 150                 155                 160


His Asn Gln Leu Leu Pro Asn Val Thr Thr Val Glu Arg Asn Ile Asp 
                165                 170                 175


Gln Glu Val Thr Ala Ala Leu Glu Thr Arg His His His Thr Gln Ile 
            180                 185                 190


Thr Ser Thr Phe Ile Ala Val Val Gln Ala Ile Val Arg Met Ala Gly 
        195                 200                 205


Gly Trp Ala Ala Ala Ser Asp Ser Arg Lys Gly Gly Glu Pro Ala Gly 
    210                 215                 220


Tyr 
225


<210>  1205
<211>  977
<212>  DNA
<213>  Homo sapiens

<400>  1205
attgaatgca gcaagggtct ggaggctgag gaccaggcag acaaacattc agagttgctg     60

gaatgcgaca gagacaggga gtcagactgg tcatgcaagg ccagctctgg ggtctcggca    120

ggtggtccgc gacatgacct ccgagttctt ctctgcccag ctccgggccc agatctctga    180

cgacaccact cacccgatct cctactacaa gcccgagttc tacatgccgg atgacggggg    240

cactgctcac ctgtctgtgg tcgcagagga cggcagtgct gtgtccgcca ccagcaccat    300

caacctctac tttggctcca aggtgcgctc cccagtcagc gggatcctgc tcaataatga    360

aatggatgac ttcagctcta ccagcatcac caacgagttt ggggtacccc cctcacctgc    420

caatttcatc cagccaggga agcagccgct ctcgtccatg tgcccgacga tcatggtggg    480

ccaggacggc caggtccgga tggtggtggg agctgccggg ggcacgcaga tcaccatggc    540

cactgcactg gccatcatct acaacctctg gttcggctat gacgtgaagt gggccgtgga    600

ggagccccgg ctgcacaacc agcttctgcc caacgtcacg acagtggaga gaaacattga    660

ccaggaagtg actgcagccc tggagacccg gcaccatcac acccagatca cgtccacctt    720

cattgctgtg gtgcaagcca tcgtccgcat ggctggtggc tgggcagctg cctcggactc    780

caggaaaggt ggggaacctg ctggctactg attgctccag gcggacaagg ctgacaagca    840

atccaggaac aaaatactca ccaggacgag gaagaggact ttgggggaca ggcttctcct    900

gtgagcagca gagcagcaca ataaatgagg ccactgtgcc aggctccagg tggcctccct    960

ggcctgtctc cccactc                                                   977


<210>  1206
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  1206

Met Thr Ser Glu Phe Phe Ser Ala Gln Leu Arg Ala Gln Ile Ser Asp 
1               5                   10                  15


Asp Thr Thr His Pro Ile Ser Tyr Tyr Lys Pro Glu Phe Tyr Met Pro 
            20                  25                  30


Asp Asp Gly Gly Thr Ala His Leu Ser Val Val Ala Glu Asp Gly Ser 
        35                  40                  45


Ala Val Ser Ala Thr Ser Thr Ile Asn Leu Tyr Phe Gly Ser Lys Val 
    50                  55                  60


Arg Ser Pro Val Ser Gly Ile Leu Leu Asn Asn Glu Met Asp Asp Phe 
65                  70                  75                  80


Ser Ser Thr Ser Ile Thr Asn Glu Phe Gly Val Pro Pro Ser Pro Ala 
                85                  90                  95


Asn Phe Ile Gln Pro Gly Lys Gln Pro Leu Ser Ser Met Cys Pro Thr 
            100                 105                 110


Ile Met Val Gly Gln Asp Gly Gln Val Arg Met Val Val Gly Ala Ala 
        115                 120                 125


Gly Gly Thr Gln Ile Thr Met Ala Thr Ala Leu Ala Ile Ile Tyr Asn 
    130                 135                 140


Leu Trp Phe Gly Tyr Asp Val Lys Trp Ala Val Glu Glu Pro Arg Leu 
145                 150                 155                 160


His Asn Gln Leu Leu Pro Asn Val Thr Thr Val Glu Arg Asn Ile Asp 
                165                 170                 175


Gln Glu Val Thr Ala Ala Leu Glu Thr Arg His His His Thr Gln Ile 
            180                 185                 190


Thr Ser Thr Phe Ile Ala Val Val Gln Ala Ile Val Arg Met Ala Gly 
        195                 200                 205


Gly Trp Ala Ala Ala Ser Asp Ser Arg Lys Gly Gly Glu Pro Ala Gly 
    210                 215                 220


Tyr 
225


<210>  1207
<211>  2437
<212>  DNA
<213>  Homo sapiens

<400>  1207
agacactggc cgcgggccac catctggacg cgatcccccg ctagggcctc cctggtctgg     60

gccaaagttg gtggccacct tcgcgcgggc tgcgccctcc ttctcttccc tgccctcctc    120

ccccggggcc cgcgcccgct gcctccagca cgcgcgtcgg caggctcggc aagcgaagag    180

gagcggctcg ccccagggcg cccctcgccc agcctgccgg ccaggcgagc gcgacgagag    240

tctccccgca ccccttcctc tcccgggggc cgagagggtt gggctccgcc ccggcgccgc    300

agctcccgac tccccgccgc tcgggctgcc gccgctgccc cgcgcccggc gctcggggca    360

gccgggggcg caggcggaga gcgcagggcg gggagaggcg tggggagcag agcggcgctg    420

aggggagggc agaggaggag agagcctggc agcggaggag cagaggcggg cgccgcaccg    480

ccccgcacgc tcgctcgctc gggagagtcg cgggcggccg cttgggcgca cttgccgggt    540

caccttgtcc cggaggagaa atggcttccc tgaggcaagt gtaacctaca ttcccagccc    600

accagcctga cgcccagcca gggagagagt accatggatg gcatcattga acagaagagc    660

atgctggtgc acagtaaaat cagtgatgct ggcaagagga atggtttaat taacaccaga    720

aacttgatgg ccgagagcag agatggtctg gtgtctgttt acccagcgcc ccagtaccag    780

agccaccggg tgggggccag cacagtgccg gccagcctgg acagcagcag gagtgagccg    840

atgcagcagc tgctggaccc caacaccctg cagcagtcag tggagtcccg ctaccggccc    900

aacatcatcc tctattcaga gggcgtgctg cgctcctggg gggacggtgt ggccgccgac    960

tgctgcgaga ccaccttcat cgaggaccgg tcgcccacca aagacagcct cgagtacccg   1020

gatgggaagt tcattgacct ctcagctgat gacataaaaa tccacaccct gtcctacgat   1080

gtggaggagg aggaggagtt ccaggagctg gagagcgact actcaagcga cacagagagt   1140

gaggacaatt tcctcatgat gcccccgcgg gaccacctgg gcctcagtgt cttctccatg   1200

ctctgctgct tctggcctct gggcatcgca gccttctact tgtcccatga gaccaacaaa   1260

gccgtggcca agggggactt gcaccaggcc agcaccagct cccggcgggc cctattcctg   1320

gcagtgctgt ccatcaccat tgggactggc gtctatgtgg gcgtggccgt ggccctcatc   1380

gcctacctct ccaagaacaa ccacctgtga gcttcctgcg aatggagggg gagcacccgg   1440

ggccaggtct gtgtggacgt ggaggaagca ggcataccgc atgatgctgt acagtacaaa   1500

tgattgccaa atgatgccac gaagccctgg gatttcctac ccatggattt attttgtttt   1560

tatcctttaa tttcatgttc acagcactgt gtagagcacc agacagacgg gcactgctaa   1620

tccttccaaa ggaaagctcc aaagatccca gcccgcaagg ctgtctctgg atggattctg   1680

gtggatgaat ggcaacgcgg ctctctgcag cctgccagtg cccagagtgc caccgcatta   1740

gcaatataca aacagtccaa aaaagtgttt attttttatg gaatacggtg caataggcag   1800

aggacaaggg acacatcact cttctgtctg tggccctgct ggagtccttt gtgccccccg   1860

gagtccacac gccttccctg caagacgaga atggggctgg gaagaaagag gcaacaccac   1920

ggctggcagg agccccgctg cactgctctg cagacccatt ggcctgaccc tgagaagcag   1980

agccagcaaa gcccgggacc tgcccctctt tctttccctt cacaccaccc cagcctcagg   2040

atgtcaagcc acctccggaa cgtgtctaca ctccacagct accccgcagc aatacgcact   2100

cttgggacct cgctgatcta ggatggggag gcaggccacc gcccctccca agactcctca   2160

agaaagagcc ccgcggttgc tccggaaact cgaggcactg cagctatggg cactgcctca   2220

gcctaaagac acaggggcgc ctcccaatca ccgcgctggc ggatgctcac cccgtcataa   2280

gcagaaacta gtgatcctgg aaatgagatg ggccttactc tgtcgactaa atgaatagct   2340

attttcttgt cattttttaa agtgcaactc ttgcttcatg ctgcttaagt taccagatga   2400

atgctgagaa ataagtaatc acagacattt taatacc                            2437


<210>  1208
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  1208

Met Asp Gly Ile Ile Glu Gln Lys Ser Met Leu Val His Ser Lys Ile 
1               5                   10                  15


Ser Asp Ala Gly Lys Arg Asn Gly Leu Ile Asn Thr Arg Asn Leu Met 
            20                  25                  30


Ala Glu Ser Arg Asp Gly Leu Val Ser Val Tyr Pro Ala Pro Gln Tyr 
        35                  40                  45


Gln Ser His Arg Val Gly Ala Ser Thr Val Pro Ala Ser Leu Asp Ser 
    50                  55                  60


Ser Arg Ser Glu Pro Met Gln Gln Leu Leu Asp Pro Asn Thr Leu Gln 
65                  70                  75                  80


Gln Ser Val Glu Ser Arg Tyr Arg Pro Asn Ile Ile Leu Tyr Ser Glu 
                85                  90                  95


Gly Val Leu Arg Ser Trp Gly Asp Gly Val Ala Ala Asp Cys Cys Glu 
            100                 105                 110


Thr Thr Phe Ile Glu Asp Arg Ser Pro Thr Lys Asp Ser Leu Glu Tyr 
        115                 120                 125


Pro Asp Gly Lys Phe Ile Asp Leu Ser Ala Asp Asp Ile Lys Ile His 
    130                 135                 140


Thr Leu Ser Tyr Asp Val Glu Glu Glu Glu Glu Phe Gln Glu Leu Glu 
145                 150                 155                 160


Ser Asp Tyr Ser Ser Asp Thr Glu Ser Glu Asp Asn Phe Leu Met Met 
                165                 170                 175


Pro Pro Arg Asp His Leu Gly Leu Ser Val Phe Ser Met Leu Cys Cys 
            180                 185                 190


Phe Trp Pro Leu Gly Ile Ala Ala Phe Tyr Leu Ser His Glu Thr Asn 
        195                 200                 205


Lys Ala Val Ala Lys Gly Asp Leu His Gln Ala Ser Thr Ser Ser Arg 
    210                 215                 220


Arg Ala Leu Phe Leu Ala Val Leu Ser Ile Thr Ile Gly Thr Gly Val 
225                 230                 235                 240


Tyr Val Gly Val Ala Val Ala Leu Ile Ala Tyr Leu Ser Lys Asn Asn 
                245                 250                 255


His Leu 



<210>  1209
<211>  8197
<212>  DNA
<213>  Homo sapiens

<400>  1209
cgttcgggca gcggcctctt gttacccggg gcccgcttgc ctcagcttct tgctgccgcc     60

agcacgctaa gctccagtcg gcgccgaagg agagcttccc gaccctcgtg tccagtagcc    120

gcaatcccag gctgggaggg tgaggcgccg cgctctgccg cccccccgcc cctcgctccc    180

tgtgtcctgg cggatttgca cgtaatctat ccgaaagccc agtcccaccc gccacccgac    240

tctggagctc ccattcttca ggaccctgct gaagtatcgc ttctcagccg ccttctccag    300

gcgcagctgc attcgcttct cggtttttgc actcgctgtg caccgagtta ctttcccggc    360

ccctcgttga caccgttcac aggtggctgt tggtctttag taagggtgct gtcttccctg    420

tctgatcctt agcaaaagta ggaaggtaga gttgttggca gaaatcctgg gataagagaa    480

tagtttcctg gaagatctgt gcctccaacc agcagagagg gattgagctt cattgaactc    540

aacagagcca acatttcata gcaccatgtt caagaggagg ttgaagtggc atggcaatgg    600

ttagagaccc tgctgggcgt gaacaccctc tggctaccta gggacctgtg ggcctaccac    660

ctggtgccct catggagaca agaagccctg ggttgaacaa catgaagccc cagtcactgc    720

agctggtact ggaagagcag gtgctggcac tacagcagca gatggcagag aatcaggcag    780

cctcctggcg gaagctgaag aactcccagg aggcccagca gagacaagca acccttgtga    840

ggaagctgca ggccaaggtg ctgcagtacc gaagctggtg ccaagagctg gagaagcggc    900

tagaagccac tggaggacca atcccccaga ggtgggaaaa tgtggaggag ccaaacctgg    960

atgagctgct ggtccgattg gaggaggagc aacagaggtg tgagagtcta gcagaggtga   1020

acacccagct tcgactgcac atggaaaaag ctgacgtggt gaataaagcc cttagggaag   1080

atgtggaaaa actgacagtg gactggagcc gggcccggga tgagctaatg aggaaggaga   1140

gccagtggca gatggagcag gagttcttca agggctacct gaaaggggag cacggtcgcc   1200

ttctcagtct atggcgggag gttgtgacat tccgacgcca cttcctggaa atgaagtcag   1260

ctactgacag agatctgatg gagctaaaag ctgagcatgt gaggctttca gggtctctgt   1320

tgacctgttg tctgcgcttg actgtgggag cacagtctcg ggaacccaac ggatctggaa   1380

gaatggatgg gcgggagccg gcccagctgc tgctgctact agccaagacc caggagctgg   1440

agaaggaagc ccatgaaagg agccaggagt taatacagct gaagagtcaa ggggatctgg   1500

agaaggctga acttcaggac cgggtgaccg agctctctgc tctgttgacc cagtctcaga   1560

agcaaaatga agattatgaa aagatgataa aggctctgag agagacagtg gagatcctgg   1620

agacaaatca cacagaatta atggaacatg aagcatctct tagtaggaat gcgcaagagg   1680

agaagttgtc tttacagcag gtgatcaagg atataaccca ggtcatggtg gaagaagggg   1740

acaatatagc ccaaggctct ggtcatgaga actctttgga attggactct agtatcttct   1800

cccagtttga ttaccaggat gcagacaagg ctcttactct ggtgcgttca gtgctgactc   1860

ggagacgcca ggctgtgcag gacctaaggc agcagcttgc aggctgtcaa gaggctgtga   1920

acttgttgca acagcagcat gatcagtggg aggaagaggg caaagccttg agacagcggc   1980

tgcagaagct cactggggag cgggacactc tggcagggca gactgtggac ctccagggag   2040

aggtggactc tctcagcaag gagcgagagc tgctgcagaa ggccagggaa gagctgcggc   2100

agcagctgga ggtgctagag caggaggcat ggcgcctgcg aagggtaaat gtggagcttc   2160

agctgcaggg ggactctgcc cagggccaga aggaggaaca gcaggaggag ctgcacctgg   2220

ctgtccggga gagggagcgt cttcaggaga tgctgatggg cctggaagcc aaacagtcag   2280

aatcactcag tgaactgatc actcttcggg aagccctgga gtcaagtcac ctggaagggg   2340

agttactgag gcaagagcaa acggaagtga ccgcagcgct ggctagggca gagcagtcaa   2400

ttgcagagct gtcgagttct gaaaacaccc tgaagacaga agtagctgat cttcgggctg   2460

cagctgtcaa gctcagtgcc ttaaatgagg ctttggcgtt agataaagtt gggctgaacc   2520

agcagcttct ccagttagag gaggagaacc agtctgtgtg cagcagaatg gaggccgcag   2580

agcaggcgag aaatgctttg caggtcgacc tggcggaggc agagaagagg agggaagccc   2640

tgtgggaaaa gaacactcac ctggaggctc agctgcagaa agctgaggag gctggggctg   2700

agctgcaggc agatctcagg gacatccaag aagagaagga agaaattcaa aagaaactaa   2760

gtgagtcacg tcaccagcag gaggcagcca cgactcagct ggagcagcta catcaggagg   2820

caaagcgaca ggaagaagtg cttgccaggg cagtccagga gaaggaggcc ctagtacgag   2880

agaaagcggc tctagaggtg cggctgcagg ccgtggagcg tgaccggcag gacctcgctg   2940

aacaactaca ggggctcagc tcagccaagg agctactgga gagcagtctg tttgaagccc   3000

aacaacaaaa ttctgtgata gaggtcacca aggggcagct ggaggtccag attcaaactg   3060

tcactcaagc caaggaagta atccaagggg aagtgaggtg cctgaagctg gaactggaca   3120

ctgaacggag tcaggcagag caggagcggg atgctgcagc cagacagctg gcccaggctg   3180

agcaagaagg gaagactgcc ttggagcagc agaaggcagc ccatgagaaa gaggtgaacc   3240

agctccggga gaaatggatg cagctggaaa cagagaagga gagagtatcc ctcctggaga   3300

cactgctgca gacgcagaag gagctagcag atgccagcca acaactggaa cgactgaggc   3360

aggacatgaa agtccagaaa ttaaaggagc aggagaccac tgggatacta cagacccagc   3420

tccaggaggc tcaacgggag ctgaaggagg cagcccggca gcacagagat gaccttgctg   3480

ccctccaaga agagagcagc tccctgctgc aggataagat ggacctgcag aagcaggtgg   3540

aggacttgaa gtctcagctg gtggcccagg atgactccca gaggctggtg gagcaggagg   3600

ttcaggagaa gctgagagag acccaggagt ataaccgaat tcagaaggag ctggagagag   3660

agaaagccag cctgactctg tcactgatgg aaaaggaaca gagactcctt gttttacaag   3720

aagctgactc tattcgacaa caagagctga gtgccctgcg ccaggacatg caggaggccc   3780

agggagaaca gaaagagctc agtgctcaga tggaattact aaggcaagag gtgaaggaaa   3840

aggaggctga ctttctggcc caggaagcac agctgctgga ggagctggag gcgtctcata   3900

tcacggagca gcagctgcga gcctccttgt gggcccagga agccaaggca gcccaactac   3960

agctgcgact gcgcagcaca gagagccagc tagaagcgct ggccgcagag cagcagcccg   4020

ggaaccaggc ccaggcccag gcccagctgg ccagcctcta ctctgccctg cagcaggccc   4080

tggggtctgt ttgtgagagc aggcctgagc tgagtggtgg gggagactct gctccttccg   4140

tctggggcct tgagccagac cagaatggag ctaggagcct ctttaagaga gggcccctgc   4200

tgactgctct ctccgctgag gcagtagcat ctgccctcca caagcttcat caagacctgt   4260

ggaagactca acagacccgg gatgttctga gggatcaggt ccagaaactg gaagagcgtc   4320

taactgatac tgaggctgag aagagccagg tccacacaga gttgcaggat ctgcagagac   4380

agctctccca gaatcaggaa gagaaatcca agtgggaagg aaagcagaac tccctagaat   4440

ctgagctgat ggaactacat gaaactatgg catccttaca gagtcgcctg cggagagcag   4500

agctacagcg aatggaagcc cagggtgagc gagagttact tcaggcagcc aaggagaacc   4560

tgacagccca ggtggaacac ctgcaagcag ctgtcgtaga agccagggct caggcaagtg   4620

ctgctggcat cctggaagaa gacctgagaa cggctcgctc agcactgaag ctgaaaaatg   4680

aggaagtaga gagtgagcgt gagagagccc aggctctgca agagcagggc gaactgaagg   4740

tggcccaagg gaaggctctg caagagaatt tggccctcct gacccagacc ctagctgaaa   4800

gagaagagga ggtggagact ctgcggggac aaatccagga actggagaag caacgggaaa   4860

tgcagaaggc tgctttggaa ttgctgtctc tggacctgaa gaagaggaac caagaggtag   4920

atctgcagca agaacagatt caggagctag agaagtgtag gtctgtttta gagcatctgc   4980

ccatggccgt ccaggagcga gagcagaagc tgactgtgca gagggagcag atcagagagc   5040

tcgagaagga tcgggagact cagaggaacg tcttggagca tcagcttcta gaacttgaga   5100

agaaagacca aatgattgag tcccagagag gacaggttca ggacctgaaa aagcagttgg   5160

ttactctgga atgcctggcc ctggaactgg aggaaaacca tcacaagatg gagtgccagc   5220

aaaaactgat caaggagctg gagggccaga gggaaaccca gagagtggct ttgacccacc   5280

ttacgctgga cctagaagaa aggagccagg agctgcaggc acaaagcagc cagatccatg   5340

acctggagag ccacagcacc gttctggcaa gagagctgca ggagagggac caggaggtga   5400

agtctcagcg agaacagatc gaggagctgc agaggcagaa agagcatctg actcaggatc   5460

tcgagaggag agaccaggag ctgatgctgc agaaggagag gattcaggtt ctcgaggatc   5520

agaggacccg gcagaccaag atcctggagg aggacctgga acagatcaag ctgtccttga   5580

gagagcgagg ccgggagctg accactcaga ggcagctgat gcaggaacgg gcagaggaag   5640

ggaagggccc aagtaaagca cagcgcggga gcctagagca catgaagctg atcctgcgtg   5700

ataaggagaa ggaggtggaa tgtcagcagg agcatatcca tgaactccag gagctcaaag   5760

accagctgga gcagcagctc cagggcctgc acaggaaggt aggtgagacc agcctcctcc   5820

tgtcccagcg agagcaggaa atagtggtcc tgcagcagca actgcaggaa gccagggaac   5880

aaggggagct gaaggagcag tcacttcaga gtcaactgga tgaggcccag agagccctag   5940

cccagaggga ccaggaactg gaggctctgc agcaagaaca gcagcaggcc cagggacagg   6000

aggagagggt gaaggaaaag gcagacgccc tccagggagc tctggagcaa gcccatatga   6060

cactgaagga gcgtcatgga gagcttcagg accacaagga acaggcacga aggctggagg   6120

aagagctggc agtggaggga cggcgggtcc aggccctgga ggaggtgctg ggagacctaa   6180

gggctgagtc tcgggaacag gagaaagctc tgttggccct ccagcagcag tgtgctgagc   6240

aggcacagga gcatgaggtg gagaccaggg ccctgcagga cagctggctg caggcccagg   6300

cagtgctcaa ggaacgggac caggagctgg aagctctgcg ggcagaaagt cagtcctccc   6360

ggcatcagga ggaggctgcc cgggcccggg ctgaggctct gcaggaggcc cttggcaagg   6420

ctcatgctgc cctgcagggg aaagagcagc atctcctcga gcaggcagaa ttgagccgca   6480

gtctggaggc cagcactgca accctgcaag cctccctgga tgcctgccag gcacacagtc   6540

ggcagctgga ggaggctctg aggatacaag aaggtgagat ccaggaccag gatctccgat   6600

accaggagga tgtgcagcag ctgcagcagg cacttgccca gagggatgaa gagctgagac   6660

atcagcagga acgggagcag ctgctggaga agtctctggc ccagagggtc caagagaata   6720

tgatccaaga gaagcagaat ctggggcaag agagagaaga ggaggagata aggggccttc   6780

atcagagtgt aagggagcta cagctgactc tagcccaaaa ggaacaggag attctggagc   6840

tgagggagac ccagcaaagg aacaacctgg aagccttacc ccacagccac aaaacctccc   6900

caatggagga acaatctcta aaacttgatt ctttagagcc caggctgcag cgggagctgg   6960

agcggctaca ggcagccctg agacagacag aagccaggga gattgagtgg agggagaagg   7020

cccaggactt ggcactctcc ctagcgcaga ccaaggccag tgtcagcagt ctgcaggagg   7080

tagccatgtt cctacaagcc tctgtcctgg agcgggactc agaacagcaa aggctgcagg   7140

atgaactgga gctcaccaga cgggctctgg agaaggagcg gctacacagc ccaggtgcaa   7200

ccagcacagc agaactgggg tccagagggg agcagggtgt gcagctggga gaggtctcag   7260

gagtggaggc tgagcctagt cctgatggaa tggagaagca gtcatggaga caaaggcttg   7320

aacacctgca gcaagcagtg gcccggctgg agattgacag gagcaggctg cagcgccaca   7380

atgtccagct gcggagtacc ttggagcagg tggagcgaga acggaggaag ctgaagaggg   7440

aggccatgcg tgcggcccag gcagggtccc tagagatcag caaggccacg gcttcttcac   7500

ccacacagca ggatgggaga ggacagaaga actcagatgc caagtgtgtg gctgaactgc   7560

agaaagaggt ggtcctgctg caagctcagc tgactttgga gcggaagcag aagcaggact   7620

acatcacccg ctcagcacag accagccgtg agctagcagg cctgcaccac agcctctcac   7680

actcacttct tgccgtggcc caggcccctg aggccactgt cctggaggca gagacccgca   7740

ggctggatga gtccctgact caaagtctga catccccagg gccagtcctg ctacacccca   7800

gccccagcac tacccaagcc gcctccaggt agcagccaca gccaggagca cacagacaga   7860

agactgtgtc atgggtcatg gcccctccgc acacctacag gtttgccaaa ggaaaagcct   7920

ggctctgtta ggcacccagg agccccaggt cggcgggtgt tcccaggaag aggaagtaaa   7980

tctgcaaccc tggggaggac cccaactcac ctgggaatga ggcaaattgc atttgcttgc   8040

tccctatgga atcacccaga ggggtgcctt gccctggctg agggacatgt actgcctctc   8100

atctagaatt tattttccta gcacttcacc acctccttca tcttctcctt caacaataaa   8160

ccctgagatc tttgcattca aaaaaaaaaa aaaaaaa                            8197


<210>  1210
<211>  2386
<212>  PRT
<213>  Homo sapiens

<400>  1210

Met Glu Thr Arg Ser Pro Gly Leu Asn Asn Met Lys Pro Gln Ser Leu 
1               5                   10                  15


Gln Leu Val Leu Glu Glu Gln Val Leu Ala Leu Gln Gln Gln Met Ala 
            20                  25                  30


Glu Asn Gln Ala Ala Ser Trp Arg Lys Leu Lys Asn Ser Gln Glu Ala 
        35                  40                  45


Gln Gln Arg Gln Ala Thr Leu Val Arg Lys Leu Gln Ala Lys Val Leu 
    50                  55                  60


Gln Tyr Arg Ser Trp Cys Gln Glu Leu Glu Lys Arg Leu Glu Ala Thr 
65                  70                  75                  80


Gly Gly Pro Ile Pro Gln Arg Trp Glu Asn Val Glu Glu Pro Asn Leu 
                85                  90                  95


Asp Glu Leu Leu Val Arg Leu Glu Glu Glu Gln Gln Arg Cys Glu Ser 
            100                 105                 110


Leu Ala Glu Val Asn Thr Gln Leu Arg Leu His Met Glu Lys Ala Asp 
        115                 120                 125


Val Val Asn Lys Ala Leu Arg Glu Asp Val Glu Lys Leu Thr Val Asp 
    130                 135                 140


Trp Ser Arg Ala Arg Asp Glu Leu Met Arg Lys Glu Ser Gln Trp Gln 
145                 150                 155                 160


Met Glu Gln Glu Phe Phe Lys Gly Tyr Leu Lys Gly Glu His Gly Arg 
                165                 170                 175


Leu Leu Ser Leu Trp Arg Glu Val Val Thr Phe Arg Arg His Phe Leu 
            180                 185                 190


Glu Met Lys Ser Ala Thr Asp Arg Asp Leu Met Glu Leu Lys Ala Glu 
        195                 200                 205


His Val Arg Leu Ser Gly Ser Leu Leu Thr Cys Cys Leu Arg Leu Thr 
    210                 215                 220


Val Gly Ala Gln Ser Arg Glu Pro Asn Gly Ser Gly Arg Met Asp Gly 
225                 230                 235                 240


Arg Glu Pro Ala Gln Leu Leu Leu Leu Leu Ala Lys Thr Gln Glu Leu 
                245                 250                 255


Glu Lys Glu Ala His Glu Arg Ser Gln Glu Leu Ile Gln Leu Lys Ser 
            260                 265                 270


Gln Gly Asp Leu Glu Lys Ala Glu Leu Gln Asp Arg Val Thr Glu Leu 
        275                 280                 285


Ser Ala Leu Leu Thr Gln Ser Gln Lys Gln Asn Glu Asp Tyr Glu Lys 
    290                 295                 300


Met Ile Lys Ala Leu Arg Glu Thr Val Glu Ile Leu Glu Thr Asn His 
305                 310                 315                 320


Thr Glu Leu Met Glu His Glu Ala Ser Leu Ser Arg Asn Ala Gln Glu 
                325                 330                 335


Glu Lys Leu Ser Leu Gln Gln Val Ile Lys Asp Ile Thr Gln Val Met 
            340                 345                 350


Val Glu Glu Gly Asp Asn Ile Ala Gln Gly Ser Gly His Glu Asn Ser 
        355                 360                 365


Leu Glu Leu Asp Ser Ser Ile Phe Ser Gln Phe Asp Tyr Gln Asp Ala 
    370                 375                 380


Asp Lys Ala Leu Thr Leu Val Arg Ser Val Leu Thr Arg Arg Arg Gln 
385                 390                 395                 400


Ala Val Gln Asp Leu Arg Gln Gln Leu Ala Gly Cys Gln Glu Ala Val 
                405                 410                 415


Asn Leu Leu Gln Gln Gln His Asp Gln Trp Glu Glu Glu Gly Lys Ala 
            420                 425                 430


Leu Arg Gln Arg Leu Gln Lys Leu Thr Gly Glu Arg Asp Thr Leu Ala 
        435                 440                 445


Gly Gln Thr Val Asp Leu Gln Gly Glu Val Asp Ser Leu Ser Lys Glu 
    450                 455                 460


Arg Glu Leu Leu Gln Lys Ala Arg Glu Glu Leu Arg Gln Gln Leu Glu 
465                 470                 475                 480


Val Leu Glu Gln Glu Ala Trp Arg Leu Arg Arg Val Asn Val Glu Leu 
                485                 490                 495


Gln Leu Gln Gly Asp Ser Ala Gln Gly Gln Lys Glu Glu Gln Gln Glu 
            500                 505                 510


Glu Leu His Leu Ala Val Arg Glu Arg Glu Arg Leu Gln Glu Met Leu 
        515                 520                 525


Met Gly Leu Glu Ala Lys Gln Ser Glu Ser Leu Ser Glu Leu Ile Thr 
    530                 535                 540


Leu Arg Glu Ala Leu Glu Ser Ser His Leu Glu Gly Glu Leu Leu Arg 
545                 550                 555                 560


Gln Glu Gln Thr Glu Val Thr Ala Ala Leu Ala Arg Ala Glu Gln Ser 
                565                 570                 575


Ile Ala Glu Leu Ser Ser Ser Glu Asn Thr Leu Lys Thr Glu Val Ala 
            580                 585                 590


Asp Leu Arg Ala Ala Ala Val Lys Leu Ser Ala Leu Asn Glu Ala Leu 
        595                 600                 605


Ala Leu Asp Lys Val Gly Leu Asn Gln Gln Leu Leu Gln Leu Glu Glu 
    610                 615                 620


Glu Asn Gln Ser Val Cys Ser Arg Met Glu Ala Ala Glu Gln Ala Arg 
625                 630                 635                 640


Asn Ala Leu Gln Val Asp Leu Ala Glu Ala Glu Lys Arg Arg Glu Ala 
                645                 650                 655


Leu Trp Glu Lys Asn Thr His Leu Glu Ala Gln Leu Gln Lys Ala Glu 
            660                 665                 670


Glu Ala Gly Ala Glu Leu Gln Ala Asp Leu Arg Asp Ile Gln Glu Glu 
        675                 680                 685


Lys Glu Glu Ile Gln Lys Lys Leu Ser Glu Ser Arg His Gln Gln Glu 
    690                 695                 700


Ala Ala Thr Thr Gln Leu Glu Gln Leu His Gln Glu Ala Lys Arg Gln 
705                 710                 715                 720


Glu Glu Val Leu Ala Arg Ala Val Gln Glu Lys Glu Ala Leu Val Arg 
                725                 730                 735


Glu Lys Ala Ala Leu Glu Val Arg Leu Gln Ala Val Glu Arg Asp Arg 
            740                 745                 750


Gln Asp Leu Ala Glu Gln Leu Gln Gly Leu Ser Ser Ala Lys Glu Leu 
        755                 760                 765


Leu Glu Ser Ser Leu Phe Glu Ala Gln Gln Gln Asn Ser Val Ile Glu 
    770                 775                 780


Val Thr Lys Gly Gln Leu Glu Val Gln Ile Gln Thr Val Thr Gln Ala 
785                 790                 795                 800


Lys Glu Val Ile Gln Gly Glu Val Arg Cys Leu Lys Leu Glu Leu Asp 
                805                 810                 815


Thr Glu Arg Ser Gln Ala Glu Gln Glu Arg Asp Ala Ala Ala Arg Gln 
            820                 825                 830


Leu Ala Gln Ala Glu Gln Glu Gly Lys Thr Ala Leu Glu Gln Gln Lys 
        835                 840                 845


Ala Ala His Glu Lys Glu Val Asn Gln Leu Arg Glu Lys Trp Met Gln 
    850                 855                 860


Leu Glu Thr Glu Lys Glu Arg Val Ser Leu Leu Glu Thr Leu Leu Gln 
865                 870                 875                 880


Thr Gln Lys Glu Leu Ala Asp Ala Ser Gln Gln Leu Glu Arg Leu Arg 
                885                 890                 895


Gln Asp Met Lys Val Gln Lys Leu Lys Glu Gln Glu Thr Thr Gly Ile 
            900                 905                 910


Leu Gln Thr Gln Leu Gln Glu Ala Gln Arg Glu Leu Lys Glu Ala Ala 
        915                 920                 925


Arg Gln His Arg Asp Asp Leu Ala Ala Leu Gln Glu Glu Ser Ser Ser 
    930                 935                 940


Leu Leu Gln Asp Lys Met Asp Leu Gln Lys Gln Val Glu Asp Leu Lys 
945                 950                 955                 960


Ser Gln Leu Val Ala Gln Asp Asp Ser Gln Arg Leu Val Glu Gln Glu 
                965                 970                 975


Val Gln Glu Lys Leu Arg Glu Thr Gln Glu Tyr Asn Arg Ile Gln Lys 
            980                 985                 990


Glu Leu Glu Arg Glu Lys Ala Ser Leu Thr Leu Ser Leu Met Glu Lys 
        995                 1000                1005


Glu Gln Arg Leu Leu Val Leu Gln Glu Ala Asp Ser Ile Arg Gln Gln 
    1010                1015                1020


Glu Leu Ser Ala Leu Arg Gln Asp Met Gln Glu Ala Gln Gly Glu Gln 
1025                1030                1035                1040


Lys Glu Leu Ser Ala Gln Met Glu Leu Leu Arg Gln Glu Val Lys Glu 
                1045                1050                1055


Lys Glu Ala Asp Phe Leu Ala Gln Glu Ala Gln Leu Leu Glu Glu Leu 
            1060                1065                1070


Glu Ala Ser His Ile Thr Glu Gln Gln Leu Arg Ala Ser Leu Trp Ala 
        1075                1080                1085


Gln Glu Ala Lys Ala Ala Gln Leu Gln Leu Arg Leu Arg Ser Thr Glu 
    1090                1095                1100


Ser Gln Leu Glu Ala Leu Ala Ala Glu Gln Gln Pro Gly Asn Gln Ala 
1105                1110                1115                1120


Gln Ala Gln Ala Gln Leu Ala Ser Leu Tyr Ser Ala Leu Gln Gln Ala 
                1125                1130                1135


Leu Gly Ser Val Cys Glu Ser Arg Pro Glu Leu Ser Gly Gly Gly Asp 
            1140                1145                1150


Ser Ala Pro Ser Val Trp Gly Leu Glu Pro Asp Gln Asn Gly Ala Arg 
        1155                1160                1165


Ser Leu Phe Lys Arg Gly Pro Leu Leu Thr Ala Leu Ser Ala Glu Ala 
    1170                1175                1180


Val Ala Ser Ala Leu His Lys Leu His Gln Asp Leu Trp Lys Thr Gln 
1185                1190                1195                1200


Gln Thr Arg Asp Val Leu Arg Asp Gln Val Gln Lys Leu Glu Glu Arg 
                1205                1210                1215


Leu Thr Asp Thr Glu Ala Glu Lys Ser Gln Val His Thr Glu Leu Gln 
            1220                1225                1230


Asp Leu Gln Arg Gln Leu Ser Gln Asn Gln Glu Glu Lys Ser Lys Trp 
        1235                1240                1245


Glu Gly Lys Gln Asn Ser Leu Glu Ser Glu Leu Met Glu Leu His Glu 
    1250                1255                1260


Thr Met Ala Ser Leu Gln Ser Arg Leu Arg Arg Ala Glu Leu Gln Arg 
1265                1270                1275                1280


Met Glu Ala Gln Gly Glu Arg Glu Leu Leu Gln Ala Ala Lys Glu Asn 
                1285                1290                1295


Leu Thr Ala Gln Val Glu His Leu Gln Ala Ala Val Val Glu Ala Arg 
            1300                1305                1310


Ala Gln Ala Ser Ala Ala Gly Ile Leu Glu Glu Asp Leu Arg Thr Ala 
        1315                1320                1325


Arg Ser Ala Leu Lys Leu Lys Asn Glu Glu Val Glu Ser Glu Arg Glu 
    1330                1335                1340


Arg Ala Gln Ala Leu Gln Glu Gln Gly Glu Leu Lys Val Ala Gln Gly 
1345                1350                1355                1360


Lys Ala Leu Gln Glu Asn Leu Ala Leu Leu Thr Gln Thr Leu Ala Glu 
                1365                1370                1375


Arg Glu Glu Glu Val Glu Thr Leu Arg Gly Gln Ile Gln Glu Leu Glu 
            1380                1385                1390


Lys Gln Arg Glu Met Gln Lys Ala Ala Leu Glu Leu Leu Ser Leu Asp 
        1395                1400                1405


Leu Lys Lys Arg Asn Gln Glu Val Asp Leu Gln Gln Glu Gln Ile Gln 
    1410                1415                1420


Glu Leu Glu Lys Cys Arg Ser Val Leu Glu His Leu Pro Met Ala Val 
1425                1430                1435                1440


Gln Glu Arg Glu Gln Lys Leu Thr Val Gln Arg Glu Gln Ile Arg Glu 
                1445                1450                1455


Leu Glu Lys Asp Arg Glu Thr Gln Arg Asn Val Leu Glu His Gln Leu 
            1460                1465                1470


Leu Glu Leu Glu Lys Lys Asp Gln Met Ile Glu Ser Gln Arg Gly Gln 
        1475                1480                1485


Val Gln Asp Leu Lys Lys Gln Leu Val Thr Leu Glu Cys Leu Ala Leu 
    1490                1495                1500


Glu Leu Glu Glu Asn His His Lys Met Glu Cys Gln Gln Lys Leu Ile 
1505                1510                1515                1520


Lys Glu Leu Glu Gly Gln Arg Glu Thr Gln Arg Val Ala Leu Thr His 
                1525                1530                1535


Leu Thr Leu Asp Leu Glu Glu Arg Ser Gln Glu Leu Gln Ala Gln Ser 
            1540                1545                1550


Ser Gln Ile His Asp Leu Glu Ser His Ser Thr Val Leu Ala Arg Glu 
        1555                1560                1565


Leu Gln Glu Arg Asp Gln Glu Val Lys Ser Gln Arg Glu Gln Ile Glu 
    1570                1575                1580


Glu Leu Gln Arg Gln Lys Glu His Leu Thr Gln Asp Leu Glu Arg Arg 
1585                1590                1595                1600


Asp Gln Glu Leu Met Leu Gln Lys Glu Arg Ile Gln Val Leu Glu Asp 
                1605                1610                1615


Gln Arg Thr Arg Gln Thr Lys Ile Leu Glu Glu Asp Leu Glu Gln Ile 
            1620                1625                1630


Lys Leu Ser Leu Arg Glu Arg Gly Arg Glu Leu Thr Thr Gln Arg Gln 
        1635                1640                1645


Leu Met Gln Glu Arg Ala Glu Glu Gly Lys Gly Pro Ser Lys Ala Gln 
    1650                1655                1660


Arg Gly Ser Leu Glu His Met Lys Leu Ile Leu Arg Asp Lys Glu Lys 
1665                1670                1675                1680


Glu Val Glu Cys Gln Gln Glu His Ile His Glu Leu Gln Glu Leu Lys 
                1685                1690                1695


Asp Gln Leu Glu Gln Gln Leu Gln Gly Leu His Arg Lys Val Gly Glu 
            1700                1705                1710


Thr Ser Leu Leu Leu Ser Gln Arg Glu Gln Glu Ile Val Val Leu Gln 
        1715                1720                1725


Gln Gln Leu Gln Glu Ala Arg Glu Gln Gly Glu Leu Lys Glu Gln Ser 
    1730                1735                1740


Leu Gln Ser Gln Leu Asp Glu Ala Gln Arg Ala Leu Ala Gln Arg Asp 
1745                1750                1755                1760


Gln Glu Leu Glu Ala Leu Gln Gln Glu Gln Gln Gln Ala Gln Gly Gln 
                1765                1770                1775


Glu Glu Arg Val Lys Glu Lys Ala Asp Ala Leu Gln Gly Ala Leu Glu 
            1780                1785                1790


Gln Ala His Met Thr Leu Lys Glu Arg His Gly Glu Leu Gln Asp His 
        1795                1800                1805


Lys Glu Gln Ala Arg Arg Leu Glu Glu Glu Leu Ala Val Glu Gly Arg 
    1810                1815                1820


Arg Val Gln Ala Leu Glu Glu Val Leu Gly Asp Leu Arg Ala Glu Ser 
1825                1830                1835                1840


Arg Glu Gln Glu Lys Ala Leu Leu Ala Leu Gln Gln Gln Cys Ala Glu 
                1845                1850                1855


Gln Ala Gln Glu His Glu Val Glu Thr Arg Ala Leu Gln Asp Ser Trp 
            1860                1865                1870


Leu Gln Ala Gln Ala Val Leu Lys Glu Arg Asp Gln Glu Leu Glu Ala 
        1875                1880                1885


Leu Arg Ala Glu Ser Gln Ser Ser Arg His Gln Glu Glu Ala Ala Arg 
    1890                1895                1900


Ala Arg Ala Glu Ala Leu Gln Glu Ala Leu Gly Lys Ala His Ala Ala 
1905                1910                1915                1920


Leu Gln Gly Lys Glu Gln His Leu Leu Glu Gln Ala Glu Leu Ser Arg 
                1925                1930                1935


Ser Leu Glu Ala Ser Thr Ala Thr Leu Gln Ala Ser Leu Asp Ala Cys 
            1940                1945                1950


Gln Ala His Ser Arg Gln Leu Glu Glu Ala Leu Arg Ile Gln Glu Gly 
        1955                1960                1965


Glu Ile Gln Asp Gln Asp Leu Arg Tyr Gln Glu Asp Val Gln Gln Leu 
    1970                1975                1980


Gln Gln Ala Leu Ala Gln Arg Asp Glu Glu Leu Arg His Gln Gln Glu 
1985                1990                1995                2000


Arg Glu Gln Leu Leu Glu Lys Ser Leu Ala Gln Arg Val Gln Glu Asn 
                2005                2010                2015


Met Ile Gln Glu Lys Gln Asn Leu Gly Gln Glu Arg Glu Glu Glu Glu 
            2020                2025                2030


Ile Arg Gly Leu His Gln Ser Val Arg Glu Leu Gln Leu Thr Leu Ala 
        2035                2040                2045


Gln Lys Glu Gln Glu Ile Leu Glu Leu Arg Glu Thr Gln Gln Arg Asn 
    2050                2055                2060


Asn Leu Glu Ala Leu Pro His Ser His Lys Thr Ser Pro Met Glu Glu 
2065                2070                2075                2080


Gln Ser Leu Lys Leu Asp Ser Leu Glu Pro Arg Leu Gln Arg Glu Leu 
                2085                2090                2095


Glu Arg Leu Gln Ala Ala Leu Arg Gln Thr Glu Ala Arg Glu Ile Glu 
            2100                2105                2110


Trp Arg Glu Lys Ala Gln Asp Leu Ala Leu Ser Leu Ala Gln Thr Lys 
        2115                2120                2125


Ala Ser Val Ser Ser Leu Gln Glu Val Ala Met Phe Leu Gln Ala Ser 
    2130                2135                2140


Val Leu Glu Arg Asp Ser Glu Gln Gln Arg Leu Gln Asp Glu Leu Glu 
2145                2150                2155                2160


Leu Thr Arg Arg Ala Leu Glu Lys Glu Arg Leu His Ser Pro Gly Ala 
                2165                2170                2175


Thr Ser Thr Ala Glu Leu Gly Ser Arg Gly Glu Gln Gly Val Gln Leu 
            2180                2185                2190


Gly Glu Val Ser Gly Val Glu Ala Glu Pro Ser Pro Asp Gly Met Glu 
        2195                2200                2205


Lys Gln Ser Trp Arg Gln Arg Leu Glu His Leu Gln Gln Ala Val Ala 
    2210                2215                2220


Arg Leu Glu Ile Asp Arg Ser Arg Leu Gln Arg His Asn Val Gln Leu 
2225                2230                2235                2240


Arg Ser Thr Leu Glu Gln Val Glu Arg Glu Arg Arg Lys Leu Lys Arg 
                2245                2250                2255


Glu Ala Met Arg Ala Ala Gln Ala Gly Ser Leu Glu Ile Ser Lys Ala 
            2260                2265                2270


Thr Ala Ser Ser Pro Thr Gln Gln Asp Gly Arg Gly Gln Lys Asn Ser 
        2275                2280                2285


Asp Ala Lys Cys Val Ala Glu Leu Gln Lys Glu Val Val Leu Leu Gln 
    2290                2295                2300


Ala Gln Leu Thr Leu Glu Arg Lys Gln Lys Gln Asp Tyr Ile Thr Arg 
2305                2310                2315                2320


Ser Ala Gln Thr Ser Arg Glu Leu Ala Gly Leu His His Ser Leu Ser 
                2325                2330                2335


His Ser Leu Leu Ala Val Ala Gln Ala Pro Glu Ala Thr Val Leu Glu 
            2340                2345                2350


Ala Glu Thr Arg Arg Leu Asp Glu Ser Leu Thr Gln Ser Leu Thr Ser 
        2355                2360                2365


Pro Gly Pro Val Leu Leu His Pro Ser Pro Ser Thr Thr Gln Ala Ala 
    2370                2375                2380


Ser Arg 
2385


<210>  1211
<211>  8365
<212>  DNA
<213>  Homo sapiens

<400>  1211
cgttcgggca gcggcctctt gttacccggg gcccgcttgc ctcagcttct tgctgccgcc     60

agcacgctaa gctccagtcg gcgccgaagg agagcttccc gaccctcgtg tccagtagcc    120

gcaatcccag gctgggaggg tgaggcgccg cgctctgccg cccccccgcc cctcgctccc    180

tgtgtcctgg cggatttgca cgtaatctat ccgaaagccc agtcccaccc gccacccgac    240

tctggagctc ccattcttca ggaccctgct gaagtatcgc ttctcagccg ccttctccag    300

gcgcagctgc attcgcttct cggtttttgc actcgctgtg caccgagtta ctttcccggc    360

ccctcgttga caccgttcac aggtggctgt tggtctttag taagggtgct gtcttccctg    420

tctgatcctt agcaaaagta ggaaggtaga gttgttggca gaaatcctgg gataagagaa    480

tagtttcctg gaagatctgt gcctccaacc agcagagagg gattgagctt cattgaactc    540

aacagagcca acatttcata gcaccatgtt caagaggagg ttgaagtggc atggcaatgg    600

ttagagaccc tgctgggcgt gaacaccctc tggctaccta gggacctgtg ggcctaccac    660

ctggtgccct catggagaca agaagccctg ggttgaacaa catgaagccc cagtcactgc    720

agctggtact ggaagagcag gtgctggcac tacagcagca gatggcagag aatcaggcag    780

cctcctggcg gaagctgaag aactcccagg aggcccagca gagacaagca acccttgtga    840

ggaagctgca ggccaaggtg ctgcagtacc gaagctggtg ccaagagctg gagaagcggc    900

tagaagccac tggaggacca atcccccaga ggtgggaaaa tgtggaggag ccaaacctgg    960

atgagctgct ggtccgattg gaggaggagc aacagaggtg tgagagtcta gcagaggtga   1020

acacccagct tcgactgcac atggaaaaag ctgacgtggt gaataaagcc cttagggaag   1080

atgtggaaaa actgacagtg gactggagcc gggcccggga tgagctaatg aggaaggaga   1140

gccagtggca gatggagcag gagttcttca agggctacct gaaaggggag cacggtcgcc   1200

ttctcagtct atggcgggag gttgtgacat tccgacgcca cttcctggaa atgaagtcag   1260

ctactgacag agatctgatg gagctaaaag ctgagcatgt gaggctttca gggtctctgt   1320

tgacctgttg tctgcgcttg actgtgggag cacagtctcg ggaacccaac ggatctggaa   1380

gaatggatgg gcgggagccg gcccagctgc tgctgctact agccaagacc caggagctgg   1440

agaaggaagc ccatgaaagg agccaggagt taatacagct gaagagtcaa ggggatctgg   1500

agaaggctga acttcaggac cgggtgaccg agctctctgc tctgttgacc cagtctcaga   1560

agcaaaatga agattatgaa aagatgataa aggctctgag agagacagtg gagatcctgg   1620

agacaaatca cacagaatta atggaacatg aagcatctct tagtaggaat gcgcaagagg   1680

agaagttgtc tttacagcag gtgatcaagg atataaccca ggtcatggtg gaagaagggg   1740

acaatatagc ccaaggctct ggtcatgaga actctttgga attggactct agtatcttct   1800

cccagtttga ttaccaggat gcagacaagg ctcttactct ggtgcgttca gtgctgactc   1860

ggagacgcca ggctgtgcag gacctaaggc agcagcttgc aggctgtcaa gaggctgtga   1920

acttgttgca acagcagcat gatcagtggg aggaagaggg caaagccttg agacagcggc   1980

tgcagaagct cactggggag cgggacactc tggcagggca gactgtggac ctccagggag   2040

aggtggactc tctcagcaag gagcgagagc tgctgcagaa ggccagggaa gagctgcggc   2100

agcagctgga ggtgctagag caggaggcat ggcgcctgcg aagggtaaat gtggagcttc   2160

agctgcaggg ggactctgcc cagggccaga aggaggaaca gcaggaggag ctgcacctgg   2220

ctgtccggga gagggagcgt cttcaggaga tgctgatggg cctggaagcc aaacagtcag   2280

aatcactcag tgaactgatc actcttcggg aagccctgga gtcaagtcac ctggaagggg   2340

agttactgag gcaagagcaa acggaagtga ccgcagcgct ggctagggca gagcagtcaa   2400

ttgcagagct gtcgagttct gaaaacaccc tgaagacaga agtagctgat cttcgggctg   2460

cagctgtcaa gctcagtgcc ttaaatgagg ctttggcgtt agataaagtt gggctgaacc   2520

agcagcttct ccagttagag gaggagaacc agtctgtgtg cagcagaatg gaggccgcag   2580

agcaggcgag aaatgctttg caggtcgacc tggcggaggc agagaagagg agggaagccc   2640

tgtgggaaaa gaacactcac ctggaggctc agctgcagaa agctgaggag gctggggctg   2700

agctgcaggc agatctcagg gacatccaag aagagaagga agaaattcaa aagaaactaa   2760

gtgagtcacg tcaccagcag gaggcagcca cgactcagct ggagcagcta catcaggagg   2820

caaagcgaca ggaagaagtg cttgccaggg cagtccagga gaaggaggcc ctagtacgag   2880

agaaagcggc tctagaggtg cggctgcagg ccgtggagcg tgaccggcag gacctcgctg   2940

aacaactaca ggggctcagc tcagccaagg agctactgga gagcagtctg tttgaagccc   3000

aacaacaaaa ttctgtgata gaggtcacca aggggcagct ggaggtccag attcaaactg   3060

tcactcaagc caaggaagta atccaagggg aagtgaggtg cctgaagctg gaactggaca   3120

ctgaacggag tcaggcagag caggagcggg atgctgcagc cagacagctg gcccaggctg   3180

agcaagaagg gaagactgcc ttggagcagc agaaggcagc ccatgagaaa gaggtgaacc   3240

agctccggga gaaatgggag aaggagcgct cctggcacca gcaggagctg gcaaaggctc   3300

tggagagctt agaaagggaa aaaatggagc tggaaatgag gctaaaggag cagcagacag   3360

aaatggaggc catccaggcc cagagggaag aagaacggac ccaggcagag agtgccctat   3420

gccagatgca gctggaaaca gagaaggaga gagtatccct cctggagaca ctgctgcaga   3480

cgcagaagga gctagcagat gccagccaac aactggaacg actgaggcag gacatgaaag   3540

tccagaaatt aaaggagcag gagaccactg ggatactaca gacccagctc caggaggctc   3600

aacgggagct gaaggaggca gcccggcagc acagagatga ccttgctgcc ctccaagaag   3660

agagcagctc cctgctgcag gataagatgg acctgcagaa gcaggtggag gacttgaagt   3720

ctcagctggt ggcccaggat gactcccaga ggctggtgga gcaggaggtt caggagaagc   3780

tgagagagac ccaggagtat aaccgaattc agaaggagct ggagagagag aaagccagcc   3840

tgactctgtc actgatggaa aaggaacaga gactccttgt tttacaagaa gctgactcta   3900

ttcgacaaca agagctgagt gccctgcgcc aggacatgca ggaggcccag ggagaacaga   3960

aagagctcag tgctcagatg gaattactaa ggcaagaggt gaaggaaaag gaggctgact   4020

ttctggccca ggaagcacag ctgctggagg agctggaggc gtctcatatc acggagcagc   4080

agctgcgagc ctccttgtgg gcccaggaag ccaaggcagc ccaactacag ctgcgactgc   4140

gcagcacaga gagccagcta gaagcgctgg ccgcagagca gcagcccggg aaccaggccc   4200

aggcccaggc ccagctggcc agcctctact ctgccctgca gcaggccctg gggtctgttt   4260

gtgagagcag gcctgagctg agtggtgggg gagactctgc tccttccgtc tggggccttg   4320

agccagacca gaatggagct aggagcctct ttaagagagg gcccctgctg actgctctct   4380

ccgctgaggc agtagcatct gccctccaca agcttcatca agacctgtgg aagactcaac   4440

agacccggga tgttctgagg gatcaggtcc agaaactgga agagcgtcta actgatactg   4500

aggctgagaa gagccaggtc cacacagagt tgcaggatct gcagagacag ctctcccaga   4560

atcaggaaga gaaatccaag tgggaaggaa agcagaactc cctagaatct gagctgatgg   4620

aactacatga aactatggca tccttacaga gtcgcctgcg gagagcagag ctacagcgaa   4680

tggaagccca gggtgagcga gagttacttc aggcagccaa ggagaacctg acagcccagg   4740

tggaacacct gcaagcagct gtcgtagaag ccagggctca ggcaagtgct gctggcatcc   4800

tggaagaaga cctgagaacg gctcgctcag cactgaagct gaaaaatgag gaagtagaga   4860

gtgagcgtga gagagcccag gctctgcaag agcagggcga actgaaggtg gcccaaggga   4920

aggctctgca agagaatttg gccctcctga cccagaccct agctgaaaga gaagaggagg   4980

tggagactct gcggggacaa atccaggaac tggagaagca acgggaaatg cagaaggctg   5040

ctttggaatt gctgtctctg gacctgaaga agaggaacca agaggtagat ctgcagcaag   5100

aacagattca ggagctagag aagtgtaggt ctgttttaga gcatctgccc atggccgtcc   5160

aggagcgaga gcagaagctg actgtgcaga gggagcagat cagagagctc gagaaggatc   5220

gggagactca gaggaacgtc ttggagcatc agcttctaga acttgagaag aaagaccaaa   5280

tgattgagtc ccagagagga caggttcagg acctgaaaaa gcagttggtt actctggaat   5340

gcctggccct ggaactggag gaaaaccatc acaagatgga gtgccagcaa aaactgatca   5400

aggagctgga gggccagagg gaaacccaga gagtggcttt gacccacctt acgctggacc   5460

tagaagaaag gagccaggag ctgcaggcac aaagcagcca gatccatgac ctggagagcc   5520

acagcaccgt tctggcaaga gagctgcagg agagggacca ggaggtgaag tctcagcgag   5580

aacagatcga ggagctgcag aggcagaaag agcatctgac tcaggatctc gagaggagag   5640

accaggagct gatgctgcag aaggagagga ttcaggttct cgaggatcag aggacccggc   5700

agaccaagat cctggaggag gacctggaac agatcaagct gtccttgaga gagcgaggcc   5760

gggagctgac cactcagagg cagctgatgc aggaacgggc agaggaaggg aagggcccaa   5820

gtaaagcaca gcgcgggagc ctagagcaca tgaagctgat cctgcgtgat aaggagaagg   5880

aggtggaatg tcagcaggag catatccatg aactccagga gctcaaagac cagctggagc   5940

agcagctcca gggcctgcac aggaaggtag gtgagaccag cctcctcctg tcccagcgag   6000

agcaggaaat agtggtcctg cagcagcaac tgcaggaagc cagggaacaa ggggagctga   6060

aggagcagtc acttcagagt caactggatg aggcccagag agccctagcc cagagggacc   6120

aggaactgga ggctctgcag caagaacagc agcaggccca gggacaggag gagagggtga   6180

aggaaaaggc agacgccctc cagggagctc tggagcaagc ccatatgaca ctgaaggagc   6240

gtcatggaga gcttcaggac cacaaggaac aggcacgaag gctggaggaa gagctggcag   6300

tggagggacg gcgggtccag gccctggagg aggtgctggg agacctaagg gctgagtctc   6360

gggaacagga gaaagctctg ttggccctcc agcagcagtg tgctgagcag gcacaggagc   6420

atgaggtgga gaccagggcc ctgcaggaca gctggctgca ggcccaggca gtgctcaagg   6480

aacgggacca ggagctggaa gctctgcggg cagaaagtca gtcctcccgg catcaggagg   6540

aggctgcccg ggcccgggct gaggctctgc aggaggccct tggcaaggct catgctgccc   6600

tgcaggggaa agagcagcat ctcctcgagc aggcagaatt gagccgcagt ctggaggcca   6660

gcactgcaac cctgcaagcc tccctggatg cctgccaggc acacagtcgg cagctggagg   6720

aggctctgag gatacaagaa ggtgagatcc aggaccagga tctccgatac caggaggatg   6780

tgcagcagct gcagcaggca cttgcccaga gggatgaaga gctgagacat cagcaggaac   6840

gggagcagct gctggagaag tctctggccc agagggtcca agagaatatg atccaagaga   6900

agcagaatct ggggcaagag agagaagagg aggagataag gggccttcat cagagtgtaa   6960

gggagctaca gctgactcta gcccaaaagg aacaggagat tctggagctg agggagaccc   7020

agcaaaggaa caacctggaa gccttacccc acagccacaa aacctcccca atggaggaac   7080

aatctctaaa acttgattct ttagagccca ggctgcagcg ggagctggag cggctacagg   7140

cagccctgag acagacagaa gccagggaga ttgagtggag ggagaaggcc caggacttgg   7200

cactctccct agcgcagacc aaggccagtg tcagcagtct gcaggaggta gccatgttcc   7260

tacaagcctc tgtcctggag cgggactcag aacagcaaag gctgcaggat gaactggagc   7320

tcaccagacg ggctctggag aaggagcggc tacacagccc aggtgcaacc agcacagcag   7380

aactggggtc cagaggggag cagggtgtgc agctgggaga ggtctcagga gtggaggctg   7440

agcctagtcc tgatggaatg gagaagcagt catggagaca aaggcttgaa cacctgcagc   7500

aagcagtggc ccggctggag attgacagga gcaggctgca gcgccacaat gtccagctgc   7560

ggagtacctt ggagcaggtg gagcgagaac ggaggaagct gaagagggag gccatgcgtg   7620

cggcccaggc agggtcccta gagatcagca aggccacggc ttcttcaccc acacagcagg   7680

atgggagagg acagaagaac tcagatgcca agtgtgtggc tgaactgcag aaagaggtgg   7740

tcctgctgca agctcagctg actttggagc ggaagcagaa gcaggactac atcacccgct   7800

cagcacagac cagccgtgag ctagcaggcc tgcaccacag cctctcacac tcacttcttg   7860

ccgtggccca ggcccctgag gccactgtcc tggaggcaga gacccgcagg ctggatgagt   7920

ccctgactca aagtctgaca tccccagggc cagtcctgct acaccccagc cccagcacta   7980

cccaagccgc ctccaggtag cagccacagc caggagcaca cagacagaag actgtgtcat   8040

gggtcatggc ccctccgcac acctacaggt ttgccaaagg aaaagcctgg ctctgttagg   8100

cacccaggag ccccaggtcg gcgggtgttc ccaggaagag gaagtaaatc tgcaaccctg   8160

gggaggaccc caactcacct gggaatgagg caaattgcat ttgcttgctc cctatggaat   8220

cacccagagg ggtgccttgc cctggctgag ggacatgtac tgcctctcat ctagaattta   8280

ttttcctagc acttcaccac ctccttcatc ttctccttca acaataaacc ctgagatctt   8340

tgcattcaaa aaaaaaaaaa aaaaa                                         8365


<210>  1212
<211>  2442
<212>  PRT
<213>  Homo sapiens

<400>  1212

Met Glu Thr Arg Ser Pro Gly Leu Asn Asn Met Lys Pro Gln Ser Leu 
1               5                   10                  15


Gln Leu Val Leu Glu Glu Gln Val Leu Ala Leu Gln Gln Gln Met Ala 
            20                  25                  30


Glu Asn Gln Ala Ala Ser Trp Arg Lys Leu Lys Asn Ser Gln Glu Ala 
        35                  40                  45


Gln Gln Arg Gln Ala Thr Leu Val Arg Lys Leu Gln Ala Lys Val Leu 
    50                  55                  60


Gln Tyr Arg Ser Trp Cys Gln Glu Leu Glu Lys Arg Leu Glu Ala Thr 
65                  70                  75                  80


Gly Gly Pro Ile Pro Gln Arg Trp Glu Asn Val Glu Glu Pro Asn Leu 
                85                  90                  95


Asp Glu Leu Leu Val Arg Leu Glu Glu Glu Gln Gln Arg Cys Glu Ser 
            100                 105                 110


Leu Ala Glu Val Asn Thr Gln Leu Arg Leu His Met Glu Lys Ala Asp 
        115                 120                 125


Val Val Asn Lys Ala Leu Arg Glu Asp Val Glu Lys Leu Thr Val Asp 
    130                 135                 140


Trp Ser Arg Ala Arg Asp Glu Leu Met Arg Lys Glu Ser Gln Trp Gln 
145                 150                 155                 160


Met Glu Gln Glu Phe Phe Lys Gly Tyr Leu Lys Gly Glu His Gly Arg 
                165                 170                 175


Leu Leu Ser Leu Trp Arg Glu Val Val Thr Phe Arg Arg His Phe Leu 
            180                 185                 190


Glu Met Lys Ser Ala Thr Asp Arg Asp Leu Met Glu Leu Lys Ala Glu 
        195                 200                 205


His Val Arg Leu Ser Gly Ser Leu Leu Thr Cys Cys Leu Arg Leu Thr 
    210                 215                 220


Val Gly Ala Gln Ser Arg Glu Pro Asn Gly Ser Gly Arg Met Asp Gly 
225                 230                 235                 240


Arg Glu Pro Ala Gln Leu Leu Leu Leu Leu Ala Lys Thr Gln Glu Leu 
                245                 250                 255


Glu Lys Glu Ala His Glu Arg Ser Gln Glu Leu Ile Gln Leu Lys Ser 
            260                 265                 270


Gln Gly Asp Leu Glu Lys Ala Glu Leu Gln Asp Arg Val Thr Glu Leu 
        275                 280                 285


Ser Ala Leu Leu Thr Gln Ser Gln Lys Gln Asn Glu Asp Tyr Glu Lys 
    290                 295                 300


Met Ile Lys Ala Leu Arg Glu Thr Val Glu Ile Leu Glu Thr Asn His 
305                 310                 315                 320


Thr Glu Leu Met Glu His Glu Ala Ser Leu Ser Arg Asn Ala Gln Glu 
                325                 330                 335


Glu Lys Leu Ser Leu Gln Gln Val Ile Lys Asp Ile Thr Gln Val Met 
            340                 345                 350


Val Glu Glu Gly Asp Asn Ile Ala Gln Gly Ser Gly His Glu Asn Ser 
        355                 360                 365


Leu Glu Leu Asp Ser Ser Ile Phe Ser Gln Phe Asp Tyr Gln Asp Ala 
    370                 375                 380


Asp Lys Ala Leu Thr Leu Val Arg Ser Val Leu Thr Arg Arg Arg Gln 
385                 390                 395                 400


Ala Val Gln Asp Leu Arg Gln Gln Leu Ala Gly Cys Gln Glu Ala Val 
                405                 410                 415


Asn Leu Leu Gln Gln Gln His Asp Gln Trp Glu Glu Glu Gly Lys Ala 
            420                 425                 430


Leu Arg Gln Arg Leu Gln Lys Leu Thr Gly Glu Arg Asp Thr Leu Ala 
        435                 440                 445


Gly Gln Thr Val Asp Leu Gln Gly Glu Val Asp Ser Leu Ser Lys Glu 
    450                 455                 460


Arg Glu Leu Leu Gln Lys Ala Arg Glu Glu Leu Arg Gln Gln Leu Glu 
465                 470                 475                 480


Val Leu Glu Gln Glu Ala Trp Arg Leu Arg Arg Val Asn Val Glu Leu 
                485                 490                 495


Gln Leu Gln Gly Asp Ser Ala Gln Gly Gln Lys Glu Glu Gln Gln Glu 
            500                 505                 510


Glu Leu His Leu Ala Val Arg Glu Arg Glu Arg Leu Gln Glu Met Leu 
        515                 520                 525


Met Gly Leu Glu Ala Lys Gln Ser Glu Ser Leu Ser Glu Leu Ile Thr 
    530                 535                 540


Leu Arg Glu Ala Leu Glu Ser Ser His Leu Glu Gly Glu Leu Leu Arg 
545                 550                 555                 560


Gln Glu Gln Thr Glu Val Thr Ala Ala Leu Ala Arg Ala Glu Gln Ser 
                565                 570                 575


Ile Ala Glu Leu Ser Ser Ser Glu Asn Thr Leu Lys Thr Glu Val Ala 
            580                 585                 590


Asp Leu Arg Ala Ala Ala Val Lys Leu Ser Ala Leu Asn Glu Ala Leu 
        595                 600                 605


Ala Leu Asp Lys Val Gly Leu Asn Gln Gln Leu Leu Gln Leu Glu Glu 
    610                 615                 620


Glu Asn Gln Ser Val Cys Ser Arg Met Glu Ala Ala Glu Gln Ala Arg 
625                 630                 635                 640


Asn Ala Leu Gln Val Asp Leu Ala Glu Ala Glu Lys Arg Arg Glu Ala 
                645                 650                 655


Leu Trp Glu Lys Asn Thr His Leu Glu Ala Gln Leu Gln Lys Ala Glu 
            660                 665                 670


Glu Ala Gly Ala Glu Leu Gln Ala Asp Leu Arg Asp Ile Gln Glu Glu 
        675                 680                 685


Lys Glu Glu Ile Gln Lys Lys Leu Ser Glu Ser Arg His Gln Gln Glu 
    690                 695                 700


Ala Ala Thr Thr Gln Leu Glu Gln Leu His Gln Glu Ala Lys Arg Gln 
705                 710                 715                 720


Glu Glu Val Leu Ala Arg Ala Val Gln Glu Lys Glu Ala Leu Val Arg 
                725                 730                 735


Glu Lys Ala Ala Leu Glu Val Arg Leu Gln Ala Val Glu Arg Asp Arg 
            740                 745                 750


Gln Asp Leu Ala Glu Gln Leu Gln Gly Leu Ser Ser Ala Lys Glu Leu 
        755                 760                 765


Leu Glu Ser Ser Leu Phe Glu Ala Gln Gln Gln Asn Ser Val Ile Glu 
    770                 775                 780


Val Thr Lys Gly Gln Leu Glu Val Gln Ile Gln Thr Val Thr Gln Ala 
785                 790                 795                 800


Lys Glu Val Ile Gln Gly Glu Val Arg Cys Leu Lys Leu Glu Leu Asp 
                805                 810                 815


Thr Glu Arg Ser Gln Ala Glu Gln Glu Arg Asp Ala Ala Ala Arg Gln 
            820                 825                 830


Leu Ala Gln Ala Glu Gln Glu Gly Lys Thr Ala Leu Glu Gln Gln Lys 
        835                 840                 845


Ala Ala His Glu Lys Glu Val Asn Gln Leu Arg Glu Lys Trp Glu Lys 
    850                 855                 860


Glu Arg Ser Trp His Gln Gln Glu Leu Ala Lys Ala Leu Glu Ser Leu 
865                 870                 875                 880


Glu Arg Glu Lys Met Glu Leu Glu Met Arg Leu Lys Glu Gln Gln Thr 
                885                 890                 895


Glu Met Glu Ala Ile Gln Ala Gln Arg Glu Glu Glu Arg Thr Gln Ala 
            900                 905                 910


Glu Ser Ala Leu Cys Gln Met Gln Leu Glu Thr Glu Lys Glu Arg Val 
        915                 920                 925


Ser Leu Leu Glu Thr Leu Leu Gln Thr Gln Lys Glu Leu Ala Asp Ala 
    930                 935                 940


Ser Gln Gln Leu Glu Arg Leu Arg Gln Asp Met Lys Val Gln Lys Leu 
945                 950                 955                 960


Lys Glu Gln Glu Thr Thr Gly Ile Leu Gln Thr Gln Leu Gln Glu Ala 
                965                 970                 975


Gln Arg Glu Leu Lys Glu Ala Ala Arg Gln His Arg Asp Asp Leu Ala 
            980                 985                 990


Ala Leu Gln Glu Glu Ser Ser Ser Leu Leu Gln Asp Lys Met Asp Leu 
        995                 1000                1005


Gln Lys Gln Val Glu Asp Leu Lys Ser Gln Leu Val Ala Gln Asp Asp 
    1010                1015                1020


Ser Gln Arg Leu Val Glu Gln Glu Val Gln Glu Lys Leu Arg Glu Thr 
1025                1030                1035                1040


Gln Glu Tyr Asn Arg Ile Gln Lys Glu Leu Glu Arg Glu Lys Ala Ser 
                1045                1050                1055


Leu Thr Leu Ser Leu Met Glu Lys Glu Gln Arg Leu Leu Val Leu Gln 
            1060                1065                1070


Glu Ala Asp Ser Ile Arg Gln Gln Glu Leu Ser Ala Leu Arg Gln Asp 
        1075                1080                1085


Met Gln Glu Ala Gln Gly Glu Gln Lys Glu Leu Ser Ala Gln Met Glu 
    1090                1095                1100


Leu Leu Arg Gln Glu Val Lys Glu Lys Glu Ala Asp Phe Leu Ala Gln 
1105                1110                1115                1120


Glu Ala Gln Leu Leu Glu Glu Leu Glu Ala Ser His Ile Thr Glu Gln 
                1125                1130                1135


Gln Leu Arg Ala Ser Leu Trp Ala Gln Glu Ala Lys Ala Ala Gln Leu 
            1140                1145                1150


Gln Leu Arg Leu Arg Ser Thr Glu Ser Gln Leu Glu Ala Leu Ala Ala 
        1155                1160                1165


Glu Gln Gln Pro Gly Asn Gln Ala Gln Ala Gln Ala Gln Leu Ala Ser 
    1170                1175                1180


Leu Tyr Ser Ala Leu Gln Gln Ala Leu Gly Ser Val Cys Glu Ser Arg 
1185                1190                1195                1200


Pro Glu Leu Ser Gly Gly Gly Asp Ser Ala Pro Ser Val Trp Gly Leu 
                1205                1210                1215


Glu Pro Asp Gln Asn Gly Ala Arg Ser Leu Phe Lys Arg Gly Pro Leu 
            1220                1225                1230


Leu Thr Ala Leu Ser Ala Glu Ala Val Ala Ser Ala Leu His Lys Leu 
        1235                1240                1245


His Gln Asp Leu Trp Lys Thr Gln Gln Thr Arg Asp Val Leu Arg Asp 
    1250                1255                1260


Gln Val Gln Lys Leu Glu Glu Arg Leu Thr Asp Thr Glu Ala Glu Lys 
1265                1270                1275                1280


Ser Gln Val His Thr Glu Leu Gln Asp Leu Gln Arg Gln Leu Ser Gln 
                1285                1290                1295


Asn Gln Glu Glu Lys Ser Lys Trp Glu Gly Lys Gln Asn Ser Leu Glu 
            1300                1305                1310


Ser Glu Leu Met Glu Leu His Glu Thr Met Ala Ser Leu Gln Ser Arg 
        1315                1320                1325


Leu Arg Arg Ala Glu Leu Gln Arg Met Glu Ala Gln Gly Glu Arg Glu 
    1330                1335                1340


Leu Leu Gln Ala Ala Lys Glu Asn Leu Thr Ala Gln Val Glu His Leu 
1345                1350                1355                1360


Gln Ala Ala Val Val Glu Ala Arg Ala Gln Ala Ser Ala Ala Gly Ile 
                1365                1370                1375


Leu Glu Glu Asp Leu Arg Thr Ala Arg Ser Ala Leu Lys Leu Lys Asn 
            1380                1385                1390


Glu Glu Val Glu Ser Glu Arg Glu Arg Ala Gln Ala Leu Gln Glu Gln 
        1395                1400                1405


Gly Glu Leu Lys Val Ala Gln Gly Lys Ala Leu Gln Glu Asn Leu Ala 
    1410                1415                1420


Leu Leu Thr Gln Thr Leu Ala Glu Arg Glu Glu Glu Val Glu Thr Leu 
1425                1430                1435                1440


Arg Gly Gln Ile Gln Glu Leu Glu Lys Gln Arg Glu Met Gln Lys Ala 
                1445                1450                1455


Ala Leu Glu Leu Leu Ser Leu Asp Leu Lys Lys Arg Asn Gln Glu Val 
            1460                1465                1470


Asp Leu Gln Gln Glu Gln Ile Gln Glu Leu Glu Lys Cys Arg Ser Val 
        1475                1480                1485


Leu Glu His Leu Pro Met Ala Val Gln Glu Arg Glu Gln Lys Leu Thr 
    1490                1495                1500


Val Gln Arg Glu Gln Ile Arg Glu Leu Glu Lys Asp Arg Glu Thr Gln 
1505                1510                1515                1520


Arg Asn Val Leu Glu His Gln Leu Leu Glu Leu Glu Lys Lys Asp Gln 
                1525                1530                1535


Met Ile Glu Ser Gln Arg Gly Gln Val Gln Asp Leu Lys Lys Gln Leu 
            1540                1545                1550


Val Thr Leu Glu Cys Leu Ala Leu Glu Leu Glu Glu Asn His His Lys 
        1555                1560                1565


Met Glu Cys Gln Gln Lys Leu Ile Lys Glu Leu Glu Gly Gln Arg Glu 
    1570                1575                1580


Thr Gln Arg Val Ala Leu Thr His Leu Thr Leu Asp Leu Glu Glu Arg 
1585                1590                1595                1600


Ser Gln Glu Leu Gln Ala Gln Ser Ser Gln Ile His Asp Leu Glu Ser 
                1605                1610                1615


His Ser Thr Val Leu Ala Arg Glu Leu Gln Glu Arg Asp Gln Glu Val 
            1620                1625                1630


Lys Ser Gln Arg Glu Gln Ile Glu Glu Leu Gln Arg Gln Lys Glu His 
        1635                1640                1645


Leu Thr Gln Asp Leu Glu Arg Arg Asp Gln Glu Leu Met Leu Gln Lys 
    1650                1655                1660


Glu Arg Ile Gln Val Leu Glu Asp Gln Arg Thr Arg Gln Thr Lys Ile 
1665                1670                1675                1680


Leu Glu Glu Asp Leu Glu Gln Ile Lys Leu Ser Leu Arg Glu Arg Gly 
                1685                1690                1695


Arg Glu Leu Thr Thr Gln Arg Gln Leu Met Gln Glu Arg Ala Glu Glu 
            1700                1705                1710


Gly Lys Gly Pro Ser Lys Ala Gln Arg Gly Ser Leu Glu His Met Lys 
        1715                1720                1725


Leu Ile Leu Arg Asp Lys Glu Lys Glu Val Glu Cys Gln Gln Glu His 
    1730                1735                1740


Ile His Glu Leu Gln Glu Leu Lys Asp Gln Leu Glu Gln Gln Leu Gln 
1745                1750                1755                1760


Gly Leu His Arg Lys Val Gly Glu Thr Ser Leu Leu Leu Ser Gln Arg 
                1765                1770                1775


Glu Gln Glu Ile Val Val Leu Gln Gln Gln Leu Gln Glu Ala Arg Glu 
            1780                1785                1790


Gln Gly Glu Leu Lys Glu Gln Ser Leu Gln Ser Gln Leu Asp Glu Ala 
        1795                1800                1805


Gln Arg Ala Leu Ala Gln Arg Asp Gln Glu Leu Glu Ala Leu Gln Gln 
    1810                1815                1820


Glu Gln Gln Gln Ala Gln Gly Gln Glu Glu Arg Val Lys Glu Lys Ala 
1825                1830                1835                1840


Asp Ala Leu Gln Gly Ala Leu Glu Gln Ala His Met Thr Leu Lys Glu 
                1845                1850                1855


Arg His Gly Glu Leu Gln Asp His Lys Glu Gln Ala Arg Arg Leu Glu 
            1860                1865                1870


Glu Glu Leu Ala Val Glu Gly Arg Arg Val Gln Ala Leu Glu Glu Val 
        1875                1880                1885


Leu Gly Asp Leu Arg Ala Glu Ser Arg Glu Gln Glu Lys Ala Leu Leu 
    1890                1895                1900


Ala Leu Gln Gln Gln Cys Ala Glu Gln Ala Gln Glu His Glu Val Glu 
1905                1910                1915                1920


Thr Arg Ala Leu Gln Asp Ser Trp Leu Gln Ala Gln Ala Val Leu Lys 
                1925                1930                1935


Glu Arg Asp Gln Glu Leu Glu Ala Leu Arg Ala Glu Ser Gln Ser Ser 
            1940                1945                1950


Arg His Gln Glu Glu Ala Ala Arg Ala Arg Ala Glu Ala Leu Gln Glu 
        1955                1960                1965


Ala Leu Gly Lys Ala His Ala Ala Leu Gln Gly Lys Glu Gln His Leu 
    1970                1975                1980


Leu Glu Gln Ala Glu Leu Ser Arg Ser Leu Glu Ala Ser Thr Ala Thr 
1985                1990                1995                2000


Leu Gln Ala Ser Leu Asp Ala Cys Gln Ala His Ser Arg Gln Leu Glu 
                2005                2010                2015


Glu Ala Leu Arg Ile Gln Glu Gly Glu Ile Gln Asp Gln Asp Leu Arg 
            2020                2025                2030


Tyr Gln Glu Asp Val Gln Gln Leu Gln Gln Ala Leu Ala Gln Arg Asp 
        2035                2040                2045


Glu Glu Leu Arg His Gln Gln Glu Arg Glu Gln Leu Leu Glu Lys Ser 
    2050                2055                2060


Leu Ala Gln Arg Val Gln Glu Asn Met Ile Gln Glu Lys Gln Asn Leu 
2065                2070                2075                2080


Gly Gln Glu Arg Glu Glu Glu Glu Ile Arg Gly Leu His Gln Ser Val 
                2085                2090                2095


Arg Glu Leu Gln Leu Thr Leu Ala Gln Lys Glu Gln Glu Ile Leu Glu 
            2100                2105                2110


Leu Arg Glu Thr Gln Gln Arg Asn Asn Leu Glu Ala Leu Pro His Ser 
        2115                2120                2125


His Lys Thr Ser Pro Met Glu Glu Gln Ser Leu Lys Leu Asp Ser Leu 
    2130                2135                2140


Glu Pro Arg Leu Gln Arg Glu Leu Glu Arg Leu Gln Ala Ala Leu Arg 
2145                2150                2155                2160


Gln Thr Glu Ala Arg Glu Ile Glu Trp Arg Glu Lys Ala Gln Asp Leu 
                2165                2170                2175


Ala Leu Ser Leu Ala Gln Thr Lys Ala Ser Val Ser Ser Leu Gln Glu 
            2180                2185                2190


Val Ala Met Phe Leu Gln Ala Ser Val Leu Glu Arg Asp Ser Glu Gln 
        2195                2200                2205


Gln Arg Leu Gln Asp Glu Leu Glu Leu Thr Arg Arg Ala Leu Glu Lys 
    2210                2215                2220


Glu Arg Leu His Ser Pro Gly Ala Thr Ser Thr Ala Glu Leu Gly Ser 
2225                2230                2235                2240


Arg Gly Glu Gln Gly Val Gln Leu Gly Glu Val Ser Gly Val Glu Ala 
                2245                2250                2255


Glu Pro Ser Pro Asp Gly Met Glu Lys Gln Ser Trp Arg Gln Arg Leu 
            2260                2265                2270


Glu His Leu Gln Gln Ala Val Ala Arg Leu Glu Ile Asp Arg Ser Arg 
        2275                2280                2285


Leu Gln Arg His Asn Val Gln Leu Arg Ser Thr Leu Glu Gln Val Glu 
    2290                2295                2300


Arg Glu Arg Arg Lys Leu Lys Arg Glu Ala Met Arg Ala Ala Gln Ala 
2305                2310                2315                2320


Gly Ser Leu Glu Ile Ser Lys Ala Thr Ala Ser Ser Pro Thr Gln Gln 
                2325                2330                2335


Asp Gly Arg Gly Gln Lys Asn Ser Asp Ala Lys Cys Val Ala Glu Leu 
            2340                2345                2350


Gln Lys Glu Val Val Leu Leu Gln Ala Gln Leu Thr Leu Glu Arg Lys 
        2355                2360                2365


Gln Lys Gln Asp Tyr Ile Thr Arg Ser Ala Gln Thr Ser Arg Glu Leu 
    2370                2375                2380


Ala Gly Leu His His Ser Leu Ser His Ser Leu Leu Ala Val Ala Gln 
2385                2390                2395                2400


Ala Pro Glu Ala Thr Val Leu Glu Ala Glu Thr Arg Arg Leu Asp Glu 
                2405                2410                2415


Ser Leu Thr Gln Ser Leu Thr Ser Pro Gly Pro Val Leu Leu His Pro 
            2420                2425                2430


Ser Pro Ser Thr Thr Gln Ala Ala Ser Arg 
        2435                2440


<210>  1213
<211>  637
<212>  DNA
<213>  Homo sapiens

<400>  1213
atgcgcgtta tgtaccctgg gattgccagc cctcaggacc ccggtaccca actgctgctg     60

cttccatttc agacggttca ggttcctggt ggaaccgaag acagcaaaga taaggtgctg    120

gtgatcagcc tctacttcct caggtatatc caggaaagtt ggctggagaa ccatggtcag    180

tatccgtcct tggagtttgt ggctctgttg tatgccttgc atacctgtga ccaggtatcc    240

ttgtttggtt ttggggaaga caattgcaaa aggtggtccc attactggga tgacaaatat    300

tggtttgaga acaccatgca aaatttccca gcagaatacc agatcatctt gaaactgcag    360

tgtgagagga agattgctgt ctacggctga gatgtttcca gtggagtccc caggaggctt    420

gacaggtagc caaggggacc ttgtggtgtc agagagggac tagggcttca agcagaccct    480

ggatggagat tactctgcta ctgaataaaa ccctagctta tttctctctc tggatttctg    540

gtggcattaa agggctacat tctattactg attctgtctt atcaccatgt gactctctta    600

tgctgtatct taccaaaaaa taaaattaaa tgagaaa                             637


<210>  1214
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  1214

Met Arg Val Met Tyr Pro Gly Ile Ala Ser Pro Gln Asp Pro Gly Thr 
1               5                   10                  15


Gln Leu Leu Leu Leu Pro Phe Gln Thr Val Gln Val Pro Gly Gly Thr 
            20                  25                  30


Glu Asp Ser Lys Asp Lys Val Leu Val Ile Ser Leu Tyr Phe Leu Arg 
        35                  40                  45


Tyr Ile Gln Glu Ser Trp Leu Glu Asn His Gly Gln Tyr Pro Ser Leu 
    50                  55                  60


Glu Phe Val Ala Leu Leu Tyr Ala Leu His Thr Cys Asp Gln Val Ser 
65                  70                  75                  80


Leu Phe Gly Phe Gly Glu Asp Asn Cys Lys Arg Trp Ser His Tyr Trp 
                85                  90                  95


Asp Asp Lys Tyr Trp Phe Glu Asn Thr Met Gln Asn Phe Pro Ala Glu 
            100                 105                 110


Tyr Gln Ile Ile Leu Lys Leu Gln Cys Glu Arg Lys Ile Ala Val Tyr 
        115                 120                 125


Gly 



<210>  1215
<211>  1368
<212>  DNA
<213>  Homo sapiens

<400>  1215
gtggctccag gccggaagag ggagtctgta ggggcgggcc ggctggcgtc ccctttccgg     60

ccggtcccca tggaggcgct ggggaagctg aagcagttcg atgcctaccc caagactttg    120

gaggacttcc gggtcaagac ctgcgggggc gccaccgtga ccattgtcag tggccttctc    180

atgctgctac tgttcctgtc cgagctgcag tattacctca ccacggaggt gcatcctgag    240

ctctacgtgg acaagtcgcg gggagataaa ctgaagatca acatcgatgt actttttccg    300

cacatgcctt gtgcctatct gagtattgat gccatggatg tggccggaga acagcagctg    360

gatgtggaac acaacctgtt caagcaacga ctagataaag atggcatccc cgtgagctca    420

gaggctgagc ggcatgagct tgggaaagtc gaggtgacgg tgtttgaccc tgactccctg    480

gaccctgatc gctgtgagag ctgctatggt gctgaggcag aagatatcaa gtgctgtaac    540

acctgtgaag atgtgcggga ggcatatcgc cgtagaggct gggccttcaa gaacccagat    600

actattgagc agtgccggcg agagggcttc agccagaaga tgcaggagca gaagaatgaa    660

ggctgccagg tgtatggctt cttggaagtc aataaggtgg ccggaaactt ccactttgcc    720

cctgggaaga gcttccagca gtcccatgtg cacgtccatg acttgcagag ctttggcctt    780

gacaacatca acatgaccca ctacatccag cacctgtcat ttggggagga ctatccaggc    840

attgtgaacc ccctggacca caccaatgtc actgcgcccc aagcctccat gatgttccag    900

tactttgtga aggtggtgcc cactgtgtac atgaaggtgg acggagaggt actgaggaca    960

aatcagttct ctgtgaccag acatgagaag gttgccaatg ggctgttggg cgaccaaggc   1020

cttcccggag tcttcgtcct ctatgagctc tcgcccatga tggtgaagct gacggagaag   1080

cacaggtcct tcacccactt cctgacaggt gtgtgcgcca tcattggggg catgttcaca   1140

gtggctggac tcatcgattc gctcatctac cactcagcac gagccatcca gaagaaaatt   1200

gatctaggga agacaacgta gtcaccctcg gtgcttcctc tgtctcctct ttctccctgg   1260

cctgtggttg tcccccagcc tctgccaccc tccacctcct cggtcagccc cagccccagg   1320

ttgataaatc tattgattga ttgtgatagt aaaaaaaaaa aaaaaaaa                1368


<210>  1216
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  1216

Met Glu Ala Leu Gly Lys Leu Lys Gln Phe Asp Ala Tyr Pro Lys Thr 
1               5                   10                  15


Leu Glu Asp Phe Arg Val Lys Thr Cys Gly Gly Ala Thr Val Thr Ile 
            20                  25                  30


Val Ser Gly Leu Leu Met Leu Leu Leu Phe Leu Ser Glu Leu Gln Tyr 
        35                  40                  45


Tyr Leu Thr Thr Glu Val His Pro Glu Leu Tyr Val Asp Lys Ser Arg 
    50                  55                  60


Gly Asp Lys Leu Lys Ile Asn Ile Asp Val Leu Phe Pro His Met Pro 
65                  70                  75                  80


Cys Ala Tyr Leu Ser Ile Asp Ala Met Asp Val Ala Gly Glu Gln Gln 
                85                  90                  95


Leu Asp Val Glu His Asn Leu Phe Lys Gln Arg Leu Asp Lys Asp Gly 
            100                 105                 110


Ile Pro Val Ser Ser Glu Ala Glu Arg His Glu Leu Gly Lys Val Glu 
        115                 120                 125


Val Thr Val Phe Asp Pro Asp Ser Leu Asp Pro Asp Arg Cys Glu Ser 
    130                 135                 140


Cys Tyr Gly Ala Glu Ala Glu Asp Ile Lys Cys Cys Asn Thr Cys Glu 
145                 150                 155                 160


Asp Val Arg Glu Ala Tyr Arg Arg Arg Gly Trp Ala Phe Lys Asn Pro 
                165                 170                 175


Asp Thr Ile Glu Gln Cys Arg Arg Glu Gly Phe Ser Gln Lys Met Gln 
            180                 185                 190


Glu Gln Lys Asn Glu Gly Cys Gln Val Tyr Gly Phe Leu Glu Val Asn 
        195                 200                 205


Lys Val Ala Gly Asn Phe His Phe Ala Pro Gly Lys Ser Phe Gln Gln 
    210                 215                 220


Ser His Val His Val His Asp Leu Gln Ser Phe Gly Leu Asp Asn Ile 
225                 230                 235                 240


Asn Met Thr His Tyr Ile Gln His Leu Ser Phe Gly Glu Asp Tyr Pro 
                245                 250                 255


Gly Ile Val Asn Pro Leu Asp His Thr Asn Val Thr Ala Pro Gln Ala 
            260                 265                 270


Ser Met Met Phe Gln Tyr Phe Val Lys Val Val Pro Thr Val Tyr Met 
        275                 280                 285


Lys Val Asp Gly Glu Val Leu Arg Thr Asn Gln Phe Ser Val Thr Arg 
    290                 295                 300


His Glu Lys Val Ala Asn Gly Leu Leu Gly Asp Gln Gly Leu Pro Gly 
305                 310                 315                 320


Val Phe Val Leu Tyr Glu Leu Ser Pro Met Met Val Lys Leu Thr Glu 
                325                 330                 335


Lys His Arg Ser Phe Thr His Phe Leu Thr Gly Val Cys Ala Ile Ile 
            340                 345                 350


Gly Gly Met Phe Thr Val Ala Gly Leu Ile Asp Ser Leu Ile Tyr His 
        355                 360                 365


Ser Ala Arg Ala Ile Gln Lys Lys Ile Asp Leu Gly Lys Thr Thr 
    370                 375                 380


<210>  1217
<211>  1383
<212>  DNA
<213>  Homo sapiens

<400>  1217
gtggctccag gccggaagag ggagtctgta ggggcgggcc ggctggcgtc ccctttccgg     60

ccggtcccca tggaggcgct ggggaagctg aagcagttcg atgcctaccc caagactttg    120

gaggacttcc gggtcaagac ctgcgggggc gccaccgtga ccattgtcag tggccttctc    180

atgctgctac tgttcctgtc cgagctgcag tattacctca ccacggaggt gcatcctgag    240

ctctacgtgg acaagtcgcg gggagataaa ctgaagatca acatcgatgt actttttccg    300

cacatgcctt gtgcctatct gagtattgat gccatggatg tggccggaga acagcagctg    360

gatgtggaac acaacctgtt caagcaacga ctagataaag atggcatccc cgtgagctca    420

gaggctgagc ggcatgagct tgggaaagtc gaggtgacgg tgtttgaccc tgactccctg    480

gaccctgatc gctgtgagag ctgctatggt gctgaggcag aagatatcaa gtgctgtaac    540

acctgtgaag atgtgcggga ggcatatcgc cgtagaggct gggccttcaa gaacccagat    600

actattgagc agtgccggcg agagggcttc agccagaaga tgcaggagca gaagaatgaa    660

ggctgccagg tgtatggctt cttggaagtc aataaggtgg ccggaaactt ccactttgcc    720

cctgggaaga gcttccagca gtcccatgtg cacgtacatg ctgtggagat ccatgacttg    780

cagagctttg gccttgacaa catcaacatg acccactaca tccagcacct gtcatttggg    840

gaggactatc caggcattgt gaaccccctg gaccacacca atgtcactgc gccccaagcc    900

tccatgatgt tccagtactt tgtgaaggtg gtgcccactg tgtacatgaa ggtggacgga    960

gaggtactga ggacaaatca gttctctgtg accagacatg agaaggttgc caatgggctg   1020

ttgggcgacc aaggccttcc cggagtcttc gtcctctatg agctctcgcc catgatggtg   1080

aagctgacgg agaagcacag gtccttcacc cacttcctga caggtgtgtg cgccatcatt   1140

gggggcatgt tcacagtggc tggactcatc gattcgctca tctaccactc agcacgagcc   1200

atccagaaga aaattgatct agggaagaca acgtagtcac cctcggtgct tcctctgtct   1260

cctctttctc cctggcctgt ggttgtcccc cagcctctgc caccctccac ctcctcggtc   1320

agccccagcc ccaggttgat aaatctattg attgattgtg atagtaaaaa aaaaaaaaaa   1380

aaa                                                                 1383


<210>  1218
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  1218

Met Glu Ala Leu Gly Lys Leu Lys Gln Phe Asp Ala Tyr Pro Lys Thr 
1               5                   10                  15


Leu Glu Asp Phe Arg Val Lys Thr Cys Gly Gly Ala Thr Val Thr Ile 
            20                  25                  30


Val Ser Gly Leu Leu Met Leu Leu Leu Phe Leu Ser Glu Leu Gln Tyr 
        35                  40                  45


Tyr Leu Thr Thr Glu Val His Pro Glu Leu Tyr Val Asp Lys Ser Arg 
    50                  55                  60


Gly Asp Lys Leu Lys Ile Asn Ile Asp Val Leu Phe Pro His Met Pro 
65                  70                  75                  80


Cys Ala Tyr Leu Ser Ile Asp Ala Met Asp Val Ala Gly Glu Gln Gln 
                85                  90                  95


Leu Asp Val Glu His Asn Leu Phe Lys Gln Arg Leu Asp Lys Asp Gly 
            100                 105                 110


Ile Pro Val Ser Ser Glu Ala Glu Arg His Glu Leu Gly Lys Val Glu 
        115                 120                 125


Val Thr Val Phe Asp Pro Asp Ser Leu Asp Pro Asp Arg Cys Glu Ser 
    130                 135                 140


Cys Tyr Gly Ala Glu Ala Glu Asp Ile Lys Cys Cys Asn Thr Cys Glu 
145                 150                 155                 160


Asp Val Arg Glu Ala Tyr Arg Arg Arg Gly Trp Ala Phe Lys Asn Pro 
                165                 170                 175


Asp Thr Ile Glu Gln Cys Arg Arg Glu Gly Phe Ser Gln Lys Met Gln 
            180                 185                 190


Glu Gln Lys Asn Glu Gly Cys Gln Val Tyr Gly Phe Leu Glu Val Asn 
        195                 200                 205


Lys Val Ala Gly Asn Phe His Phe Ala Pro Gly Lys Ser Phe Gln Gln 
    210                 215                 220


Ser His Val His Val His Ala Val Glu Ile His Asp Leu Gln Ser Phe 
225                 230                 235                 240


Gly Leu Asp Asn Ile Asn Met Thr His Tyr Ile Gln His Leu Ser Phe 
                245                 250                 255


Gly Glu Asp Tyr Pro Gly Ile Val Asn Pro Leu Asp His Thr Asn Val 
            260                 265                 270


Thr Ala Pro Gln Ala Ser Met Met Phe Gln Tyr Phe Val Lys Val Val 
        275                 280                 285


Pro Thr Val Tyr Met Lys Val Asp Gly Glu Val Leu Arg Thr Asn Gln 
    290                 295                 300


Phe Ser Val Thr Arg His Glu Lys Val Ala Asn Gly Leu Leu Gly Asp 
305                 310                 315                 320


Gln Gly Leu Pro Gly Val Phe Val Leu Tyr Glu Leu Ser Pro Met Met 
                325                 330                 335


Val Lys Leu Thr Glu Lys His Arg Ser Phe Thr His Phe Leu Thr Gly 
            340                 345                 350


Val Cys Ala Ile Ile Gly Gly Met Phe Thr Val Ala Gly Leu Ile Asp 
        355                 360                 365


Ser Leu Ile Tyr His Ser Ala Arg Ala Ile Gln Lys Lys Ile Asp Leu 
    370                 375                 380


Gly Lys Thr Thr 
385


<210>  1219
<211>  4024
<212>  DNA
<213>  Homo sapiens

<400>  1219
tgcccctctg tcactgcaag ccatgcatgc atgtgtggag ttgctgggag gaccacacct     60

ggcgcctgca gagcagcaac tgcgtgcgca aagtggccga gaggctggac caggggctgc    120

aggaggttga gagactgcag cgcaagccgg ggcctggcgc ctgtgcacag ctcaagcagg    180

cactggaagt gctggtggct gggagcagac agttttgcca cggtgccgag cgcaggacga    240

tgacccggcc caatgccctg gatcgatgcc gagggaaact cctggtgcac agcctgaacc    300

ttttggctaa gcaaggactg cgacttctac gcagcctgag acggcgcaat gtgcaaaaga    360

aggtggcact ggccaagaag ctcctggcaa aactgcgctt tctggctgag gagcacaact    420

ttgatgaaga tgaaatggat gatcctggag attcagatgg ggtcaacctc atttctatgg    480

ttggggagat ccaagaccag ggtgaggctg aagtcaaagg cactgtgtcc ccaaaaaaag    540

cagttgccac cctgaagatc tacaacaggt ccctggagga agaatttaac cactttgaag    600

actggctgaa tgtgtttcct ctgtaccgag ggcaaggggg ccaggatgga ggtggagaag    660

aggaaggatc tggacacctt gtgggcaagt tcaagggctc cttcctcatt taccctgaat    720

cagaggcagt gttgttctct gagccccaga tctcccgggg gatcccacag aaccggccca    780

tcaagctcct ggtcagagtg tatgttgtaa agctaagaaa cctttgcaaa atccaaggtc    840

atgaagactt ttgcctgttt tctgctgcta ccaacctggc tcctgcagac cccaatggca    900

aagcagaccc ttacgtggtg gtgagcgctg gccgggagcg gcaggacacc aaggaacgct    960

acatccccaa gcagctcaac cccatctttg gagagatcct ggagctaagc atctctctcc   1020

cagctgagac ggagctgacg gtcgccgtat ttgatcatga cctcgtgggt tctgacgacc   1080

tcatcgggga gacccacatt gatctggaaa accgattcta tagccaccac agagcaaact   1140

gtggactggc ctcccagtat gaagtgtggg tccagcaggg cccacaggag ccattctgag   1200

tttctggcca aacacattca agctcacatt cccttttgtg tctccagatc ctatgatttc   1260

atggaagggg accctcccac ccaccgccac tgccaaccaa gacatagctc agtggtcaag   1320

acttgggctt gggagtcggg atcctgtaac gaatgtcact tgaccgcttt ctttttttat   1380

gaaacagtct cgctctgtct cccaggttgg agtgcagtgg cacgatctcg gctgactgca   1440

acctccacct cctgggttca agcgattctc ctgcctcagc ctccccagta gctgggatta   1500

caggcgtggg cccccatgtc cagctaattt ttatattttc gctctgtctc ccaggttgga   1560

gtgcagtggc acgatctcgg ctgactgcaa cctccacctc ctgggttcaa gcgattctcc   1620

tgcctcagcc tccccagtag ctgggattac aggcgtgggc ccccatgtcc agctaatttt   1680

tatattttta gtagagacag ggtttcacca tgttgtccag gctggtcttg aacccctgac   1740

ctcaagtgat ccacccacct ctgcctccca aagtgctggg attacaggtg tgagccacca   1800

tgccaggccc acttaacctc ttcaagtctg ttttctcatc tgcaaaacag aggtaataag   1860

atcagtatct tcttaatgga agcacctgga ctacattttt ttcattcatt gttatcataa   1920

atgaggacta acctgtctcc cgttgggagt tttgaaccta gacctcatgt cttcatgacg   1980

tcatcactgc cccaggccca gctgtgtccc tacaccagcc ccagctgacg catcttcttt   2040

ttctgcctgt agagatggtt acaatgcctg gcgtgatgca ttctggcctt cgcagatcct   2100

ggcggggctg tgccaacgct gtggcctccc tgcccctgaa taccgagccg gtgctgtcaa   2160

ggtgggcagc aaagtcttcc tgacaccacc ggagaccctg cccccaggga tctcttcaca   2220

tgtggattga catctttcct caagatgtgc ctgctccacc cccagttgac atcaagcctc   2280

ggcagccaat cagctatgag ctcagagttg tcatctggaa cacggaggat gtggttctgg   2340

atgacgagaa tccactcacc ggagagatgt cgagtgccat ctatgtgaag aggtaggctg   2400

ctggccgggc ggggcaacgg cggtgcacta gggggattgc aaatgggtgt gggccctcgg   2460

gctgagtcca gagccccgac cccaggccct ccgtggtgct gagagcgggg tgaggagtgg   2520

gttctccatg tagctccagc cctgacgctc acccaccccg gccccagctg ggtgaagggg   2580

ttggagcatg acaagcagga gacagacgtt cacttcaact ccctgactgg ggaggggaac   2640

ttcaattggc gctttgtgtt ccgctttgac tacctgccca cggagcggga ggtgagcatc   2700

cggcgcaggt ctggaccctt tgccctggag gaggcggagt tccggcagcc tgcagtgctg   2760

gtcctgcagg tctgggacta tgaccgcatc tctgccaatg acttccttgg tattacaatg   2820

cttagccttc cccaccctca gcccctgcct ccagccctca cctccgcccc tgcctccagc   2880

cctcacttcc gtcccccagt tccctactct gacccaacct tgaatcttgg gattttggac   2940

ccgaggtgtg aaacctttgc tttctggcct aattactgag ttaattaggc ctagaccaca   3000

gtaacctcca ttcccaccca gagtctctga ttcaactctg atttgaccct agcttgtcac   3060

cctgacaccg actccacagc ctttggtcct tggcactctg atcccgaccc ttggccctct   3120

tccactggga agtagcaatg ggtggaccgc tgggctgtgg tctgggtggt ctatagctgt   3180

ggcctgaccg cacactgcaa caactttcaa tgccccaatt tacaaccttg gtgtgttgcc   3240

tcctcacccc tggcacaatg agactttgat cccatgccta atctggtgtg ctctggactt   3300

gcaggatccc tggagttgca gctaccagac atggtgcgtg gggcccgggg ccccgagctc   3360

tgctctgtgc agctggcccg caatggggcc gggccgaggt gcaatctgtt tcgctgccgc   3420

cgcctgaggg gctggtggcc ggtagtgaag ctgaaggagg cagaggacgt ggagcgggag   3480

gcgcaggagg ctcaggctgg caagaagaag cgaaagcaga ggaggaggaa gggccggcca   3540

gaagacctgg agttcacaga catgggtggc aatgtgtaca tcctcacggg caaggtggag   3600

gcagagtttg agctgctgac tgtggaggag gccgagaaac ggccagtggg gaaggggcgg   3660

aagcagccag agcctctgga gaaacccagc cgccccaaaa cttccttcaa ctggtttgtg   3720

aacccgctga aggcctttgt cttcttcatc tggcgccggt actggcgcac cctggtgctg   3780

ctgctactgg tgctgctcac cgtcttcctc ctcctggtct tctacaccat ccctggccag   3840

atcagccagg tcatcttccg tcccctccac aagtgactct cgctgacctt ggacactcac   3900

ccagggtgcc aacccttcaa tgcctgctcc tggaagtctt tcttacccat gtgagctacc   3960

ccagagtcta gtgcttcctc tgaataaacc tatcacagcc actgaaaaaa aaaaaaaaaa   4020

aaaa                                                                4024


<210>  1220
<211>  1452
<212>  DNA
<213>  Homo sapiens

<400>  1220
cgacttcacg cagggtccgt ggggtccccg cggcgcgcag cggctgaagg aggccccagg     60

gccttggcga ccgcagcggc ggctttagcg tcagtgacta ggcagcaggg ggtcaggatg    120

cggcgaagct cccgcccggg ctcggcctcg tcctcgcgca agcacacgcc caactttttc    180

agcgagaaca gctcaatgag catcacctcg gaggacagca aagggctccg gtcagcggag    240

cccgggcctg gggagcccga gggcagaaga gcccggggcc cgagctgcgg tgagcccgcc    300

ttgagcgcgg gagtgcccgg aggaaccaca tgggcaggaa gctctcagca gaagccagcg    360

cctcggagcc acaactggca gacagcctgt ggcgcggcaa ccgtgagggg cggggcctcg    420

gaaccgactg ggtctccagt agtctctgag gagccgctcg accttctccc gaccctggat    480

ctgaggcagg agatgcctcc cccgcgggtg ttcaagagct ttctgagcct gctcttccag    540

gggctgagcg tgttgttatc cctggcagga gacgtgctgg tcagcatgta cagggaggtc    600

tgttccatcc gcttcctgtt cacggctgtg tcgctgctga gcctctttct gtcagcattc    660

tggctggggc ttctgtacct ggtctctcct ttggagaatg aacctaagga gatgctgact    720

ctaagtgagt accacgagcg cgtgcgctcc caggggcagc agctgcagca gctccaggcc    780

gagctggata aactccacaa ggaggtgtcc actgttcggg cagccaacag cgagagagtg    840

gccaagctcg tgttccagag gctgaatgag gattttgtgc ggaagcccga ctatgctttg    900

agctctgtgg gagcctccat cgacctgcag aagacatccc acgattacgc agacaggaac    960

actgcctact tctggaatcg cttcagcttc tggaactacg cacggccgcc cacggttatc   1020

ctggagcccc acgtgttccc tgggaattgc tgggcttttg aaggcgacca aggccaggtg   1080

gtgatccaac tgccgggccg agtgcagctg agcgacatca ctctgcagca tccaccgccc   1140

agcgtggagc acaccggagg agccaacagc gccccccgcg atttcgcggt ctttggcctc   1200

caggtttatg atgaaactga agtttccttg gggaaattca ccttcgatgt tgagaaatcg   1260

gagattcaga ctttccacct gcagaatgac cccccagctg cctttcccaa ggtgaagatc   1320

cagattctaa gcaactgggg ccacccccgt ttcacgtgct tgtatcgagt ccgtgcccac   1380

ggtgtgcgaa cctcagaggg ggcagagggc agtgcacagg ggccccatta aacatgctga   1440

tttttggagt ag                                                       1452


<210>  1221
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  1221

Met Arg Arg Ser Ser Arg Pro Gly Ser Ala Ser Ser Ser Arg Lys His 
1               5                   10                  15


Thr Pro Asn Phe Phe Ser Glu Asn Ser Ser Met Ser Ile Thr Ser Glu 
            20                  25                  30


Asp Ser Lys Gly Leu Arg Ser Ala Glu Pro Gly Pro Gly Glu Pro Glu 
        35                  40                  45


Gly Arg Arg Ala Arg Gly Pro Ser Cys Gly Glu Pro Ala Leu Ser Ala 
    50                  55                  60


Gly Val Pro Gly Gly Thr Thr Trp Ala Gly Ser Ser Gln Gln Lys Pro 
65                  70                  75                  80


Ala Pro Arg Ser His Asn Trp Gln Thr Ala Cys Gly Ala Ala Thr Val 
                85                  90                  95


Arg Gly Gly Ala Ser Glu Pro Thr Gly Ser Pro Val Val Ser Glu Glu 
            100                 105                 110


Pro Leu Asp Leu Leu Pro Thr Leu Asp Leu Arg Gln Glu Met Pro Pro 
        115                 120                 125


Pro Arg Val Phe Lys Ser Phe Leu Ser Leu Leu Phe Gln Gly Leu Ser 
    130                 135                 140


Val Leu Leu Ser Leu Ala Gly Asp Val Leu Val Ser Met Tyr Arg Glu 
145                 150                 155                 160


Val Cys Ser Ile Arg Phe Leu Phe Thr Ala Val Ser Leu Leu Ser Leu 
                165                 170                 175


Phe Leu Ser Ala Phe Trp Leu Gly Leu Leu Tyr Leu Val Ser Pro Leu 
            180                 185                 190


Glu Asn Glu Pro Lys Glu Met Leu Thr Leu Ser Glu Tyr His Glu Arg 
        195                 200                 205


Val Arg Ser Gln Gly Gln Gln Leu Gln Gln Leu Gln Ala Glu Leu Asp 
    210                 215                 220


Lys Leu His Lys Glu Val Ser Thr Val Arg Ala Ala Asn Ser Glu Arg 
225                 230                 235                 240


Val Ala Lys Leu Val Phe Gln Arg Leu Asn Glu Asp Phe Val Arg Lys 
                245                 250                 255


Pro Asp Tyr Ala Leu Ser Ser Val Gly Ala Ser Ile Asp Leu Gln Lys 
            260                 265                 270


Thr Ser His Asp Tyr Ala Asp Arg Asn Thr Ala Tyr Phe Trp Asn Arg 
        275                 280                 285


Phe Ser Phe Trp Asn Tyr Ala Arg Pro Pro Thr Val Ile Leu Glu Pro 
    290                 295                 300


His Val Phe Pro Gly Asn Cys Trp Ala Phe Glu Gly Asp Gln Gly Gln 
305                 310                 315                 320


Val Val Ile Gln Leu Pro Gly Arg Val Gln Leu Ser Asp Ile Thr Leu 
                325                 330                 335


Gln His Pro Pro Pro Ser Val Glu His Thr Gly Gly Ala Asn Ser Ala 
            340                 345                 350


Pro Arg Asp Phe Ala Val Phe Gly Leu Gln Val Tyr Asp Glu Thr Glu 
        355                 360                 365


Val Ser Leu Gly Lys Phe Thr Phe Asp Val Glu Lys Ser Glu Ile Gln 
    370                 375                 380


Thr Phe His Leu Gln Asn Asp Pro Pro Ala Ala Phe Pro Lys Val Lys 
385                 390                 395                 400


Ile Gln Ile Leu Ser Asn Trp Gly His Pro Arg Phe Thr Cys Leu Tyr 
                405                 410                 415


Arg Val Arg Ala His Gly Val Arg Thr Ser Glu Gly Ala Glu Gly Ser 
            420                 425                 430


Ala Gln Gly Pro His 
        435


<210>  1222
<211>  2211
<212>  DNA
<213>  Homo sapiens

<400>  1222
ggcgaaggct ttgtagagtt cagaaatgag gctgactata aggctgctct gtgtcgtcat     60

aaacagtaca tgggcaatcg ctttattcaa gttcatccaa ttactaagaa aggtatgcta    120

gaaaagatag atatgattcg aaaaagactg cagaacttca gctatgacca gagggaaatg    180

atactaaatc cagaggggga tgtcaactct gccaaagtct gtgcccacat aacaaatatt    240

ccattcagca ttacaaagat ggatgttctt cagttcctag aaggaatccc agtggatgaa    300

aatgctgtac atgttcttgt tgataacaat gggcaaggtc taggacaggc attggttcag    360

tttaaaaatg aagatgatgc acatggccca ctgcgtgacc ttggttcagc tgtccatttc    420

ctgtgaccat ctcattgaca aggacatcgg ctccaagtct gacccactct gcgtcctttt    480

acaggatgtg ggagggggca gctgggctga gcttggccgg actgaacggg tgcggaactg    540

ctcaagccct gagttctcca agactctaca gcttgagtac cgctttgaga cagtccagaa    600

gctacgcttt ggaatctatg acatagacaa caagacgcca gagctgaggg atgatgactt    660

cctagggggt gctgagtgtt ccctaggaca gattgtgtcc agccaggtac tgactctccc    720

cttgatgctg aagcctggaa aacctgctgg gcgggggacc atcacggtct cagctcagga    780

attaaaggac aatcgtgtag taaccatgga ggtagaggcc agaaacctag ataagaagga    840

cttcctggga aaatcagatc catttctgga gttcttccgc cagggtgatg ggaaatggca    900

cctggtgtac agatctgagg tcatcaagaa caacctgaac cctacatgga agcgtttctc    960

agtccccgtt cagcatttct gtggtgggaa ccccagcaca cccatccagg tgcaatgctc   1020

cgattatgac agtgacgggt cacatgatct catcggtacc ttccacacca gcttggccca   1080

gctgcaggca gtcccggctg agtttgaatg catccaccct gagaagcagc agaaaaagaa   1140

aagctacaag aactctggaa ctatccgtgt caagatttgt cgggtagaaa cagagtactc   1200

ctttctggac tatgtgatgg gaggctgtca gatcaacttc actgtgggcg tggacttcac   1260

tggctccaat ggagacccct cctcacctga ctccctacac tacctgagtc caacaggggt   1320

caatgagtac ctgatggcac tgtggagtgt gggcagcgtg gttcaggact atgactcaga   1380

caagctgttc cctgcatttg gatttggggc ccaggttccc cctgactggc aggtctcgca   1440

tgaatttgcc ttgaatttca accccagtaa cccctactgt gcaggcatcc agggcattgt   1500

ggatgcctac cgccaagccc tgccccaagt tcgcctctat ggccctacca actttgcacc   1560

catcatcaac catgtggcca ggtttgcagc ccaggctgca catcagggga ctgcctcgca   1620

atacttcatg ctgttgctgc tgactgatgg tgctgtgacg gatgtggaag ccacacgtga   1680

ggctgtggtg cgtgcctcga acctgcccat gtcagtgatc attgtgggtg tgggtggtgc   1740

tgactttgag gccatggagc agctggacgc tgatggtgga cccctgcata cacgttctgg   1800

gcaggctgct gcccgcgaca ttgtgcagtt tgtaccctac cgccggttcc agaatgcccc   1860

tcgggaggca ttggcacaga ccgtgctcgc agaagtgccc acacaactgg tctcatactt   1920

cagggcccag ggttgggccc cgctcaagcc acttccaccc tcagccaagg atcctgcaca   1980

ggccccccag gcctaggttc ccttggaggc tgtggcaagt cctcaatcct gtgtcccaga   2040

ggtccctctg ggccacaacc caacccttct cactctcctc agtgctagca ctttgtattt   2100

tttgatactt ttatacttgt ttctgctttt gctgctcttg atcccacctt tgctcctgac   2160

aaccctcatt caataaagac cagtgaagac caaaaaaaaa aaaaaaaaaa a            2211


<210>  1223
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  1223

Met Ala His Cys Val Thr Leu Val Gln Leu Ser Ile Ser Cys Asp His 
1               5                   10                  15


Leu Ile Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val Leu 
            20                  25                  30


Leu Gln Asp Val Gly Gly Gly Ser Trp Ala Glu Leu Gly Arg Thr Glu 
        35                  40                  45


Arg Val Arg Asn Cys Ser Ser Pro Glu Phe Ser Lys Thr Leu Gln Leu 
    50                  55                  60


Glu Tyr Arg Phe Glu Thr Val Gln Lys Leu Arg Phe Gly Ile Tyr Asp 
65                  70                  75                  80


Ile Asp Asn Lys Thr Pro Glu Leu Arg Asp Asp Asp Phe Leu Gly Gly 
                85                  90                  95


Ala Glu Cys Ser Leu Gly Gln Ile Val Ser Ser Gln Val Leu Thr Leu 
            100                 105                 110


Pro Leu Met Leu Lys Pro Gly Lys Pro Ala Gly Arg Gly Thr Ile Thr 
        115                 120                 125


Val Ser Ala Gln Glu Leu Lys Asp Asn Arg Val Val Thr Met Glu Val 
    130                 135                 140


Glu Ala Arg Asn Leu Asp Lys Lys Asp Phe Leu Gly Lys Ser Asp Pro 
145                 150                 155                 160


Phe Leu Glu Phe Phe Arg Gln Gly Asp Gly Lys Trp His Leu Val Tyr 
                165                 170                 175


Arg Ser Glu Val Ile Lys Asn Asn Leu Asn Pro Thr Trp Lys Arg Phe 
            180                 185                 190


Ser Val Pro Val Gln His Phe Cys Gly Gly Asn Pro Ser Thr Pro Ile 
        195                 200                 205


Gln Val Gln Cys Ser Asp Tyr Asp Ser Asp Gly Ser His Asp Leu Ile 
    210                 215                 220


Gly Thr Phe His Thr Ser Leu Ala Gln Leu Gln Ala Val Pro Ala Glu 
225                 230                 235                 240


Phe Glu Cys Ile His Pro Glu Lys Gln Gln Lys Lys Lys Ser Tyr Lys 
                245                 250                 255


Asn Ser Gly Thr Ile Arg Val Lys Ile Cys Arg Val Glu Thr Glu Tyr 
            260                 265                 270


Ser Phe Leu Asp Tyr Val Met Gly Gly Cys Gln Ile Asn Phe Thr Val 
        275                 280                 285


Gly Val Asp Phe Thr Gly Ser Asn Gly Asp Pro Ser Ser Pro Asp Ser 
    290                 295                 300


Leu His Tyr Leu Ser Pro Thr Gly Val Asn Glu Tyr Leu Met Ala Leu 
305                 310                 315                 320


Trp Ser Val Gly Ser Val Val Gln Asp Tyr Asp Ser Asp Lys Leu Phe 
                325                 330                 335


Pro Ala Phe Gly Phe Gly Ala Gln Val Pro Pro Asp Trp Gln Val Ser 
            340                 345                 350


His Glu Phe Ala Leu Asn Phe Asn Pro Ser Asn Pro Tyr Cys Ala Gly 
        355                 360                 365


Ile Gln Gly Ile Val Asp Ala Tyr Arg Gln Ala Leu Pro Gln Val Arg 
    370                 375                 380


Leu Tyr Gly Pro Thr Asn Phe Ala Pro Ile Ile Asn His Val Ala Arg 
385                 390                 395                 400


Phe Ala Ala Gln Ala Ala His Gln Gly Thr Ala Ser Gln Tyr Phe Met 
                405                 410                 415


Leu Leu Leu Leu Thr Asp Gly Ala Val Thr Asp Val Glu Ala Thr Arg 
            420                 425                 430


Glu Ala Val Val Arg Ala Ser Asn Leu Pro Met Ser Val Ile Ile Val 
        435                 440                 445


Gly Val Gly Gly Ala Asp Phe Glu Ala Met Glu Gln Leu Asp Ala Asp 
    450                 455                 460


Gly Gly Pro Leu His Thr Arg Ser Gly Gln Ala Ala Ala Arg Asp Ile 
465                 470                 475                 480


Val Gln Phe Val Pro Tyr Arg Arg Phe Gln Asn Ala Pro Arg Glu Ala 
                485                 490                 495


Leu Ala Gln Thr Val Leu Ala Glu Val Pro Thr Gln Leu Val Ser Tyr 
            500                 505                 510


Phe Arg Ala Gln Gly Trp Ala Pro Leu Lys Pro Leu Pro Pro Ser Ala 
        515                 520                 525


Lys Asp Pro Ala Gln Ala Pro Gln Ala 
    530                 535


<210>  1224
<211>  1996
<212>  DNA
<213>  Homo sapiens

<400>  1224
cggagccgct gagcgggccg acggccattt tgtgaagcgg cgaaggaggt ggtggctgcg     60

ttgggctccg ggaagccgtt cgggctgggg ctgtcggccg cggggcggag gcactcgcgc    120

ggggggtaat tcggggtctg ggttctggtg ccgcgcagct ttccccgatg gcccactgcg    180

tgaccttggt tcagctgtcc atttcctgtg accatctcat tgacaaggac atcggctcca    240

agtctgaccc actctgcgtc cttttacagg atgtgggagg gggcagctgg gctgagcttg    300

gccggactga acgggtgcgg aactgctcaa gccctgagtt ctccaagact ctacagcttg    360

agtaccgctt tgagacagtc cagaagctac gctttggaat ctatgacata gacaacaaga    420

cgccagagct gagggatgat gacttcctag ggggtgctga gtgttcccta ggacagattg    480

tgtccagcca ggtactgact ctccccttga tgctgaagcc tggaaaacct gctgggcggg    540

ggaccatcac ggtctcagct caggaattaa aggacaatcg tgtagtaacc atggaggtag    600

aggccagaaa cctagataag aaggacttcc tgggaaaatc agatccattt ctggagttct    660

tccgccaggg tgatgggaaa tggcacctgg tgtacagatc tgaggtcatc aagaacaacc    720

tgaaccctac atggaagcgt ttctcagtcc ccgttcagca tttctgtggt gggaacccca    780

gcacacccat ccaggtgcaa tgctccgatt atgacagtga cgggtcacat gatctcatcg    840

gtaccttcca caccagcttg gcccagctgc aggcagtccc ggctgagttt gaatgcatcc    900

accctgagaa gcagcagaaa aagaaaagct acaagaactc tggaactatc cgtgtcaaga    960

tttgtcgggt agaaacagag tactcctttc tggactatgt gatgggaggc tgtcagatca   1020

acttcactgt gggcgtggac ttcactggct ccaatggaga cccctcctca cctgactccc   1080

tacactacct gagtccaaca ggggtcaatg agtacctgat ggcactgtgg agtgtgggca   1140

gcgtggttca ggactatgac tcagacaagc tgttccctgc atttggattt ggggcccagg   1200

ttccccctga ctggcaggtc tcgcatgaat ttgccttgaa tttcaacccc agtaacccct   1260

actgtgcagg catccagggc attgtggatg cctaccgcca agccctgccc caagttcgcc   1320

tctatggccc taccaacttt gcacccatca tcaaccatgt ggccaggttt gcagcccagg   1380

ctgcacatca ggggactgcc tcgcaatact tcatgctgtt gctgctgact gatggtgctg   1440

tgacggatgt ggaagccaca cgtgaggctg tggtgcgtgc ctcgaacctg cccatgtcag   1500

tgatcattgt gggtgtgggt ggtgctgact ttgaggccat ggagcagctg gacgctgatg   1560

gtggacccct gcatacacgt tctgggcagg ctgctgcccg cgacattgtg cagtttgtac   1620

cctaccgccg gttccagaat gcccctcggg aggcattggc acagaccgtg ctcgcagaag   1680

tgcccacaca actggtctca tacttcaggg cccagggttg ggccccgctc aagccacttc   1740

caccctcagc caaggatcct gcacaggccc cccaggccta ggttcccttg gaggctgtgg   1800

caagtcctca atcctgtgtc ccagaggtcc ctctgggcca caacccaacc cttctcactc   1860

tcctcagtgc tagcactttg tattttttga tacttttata cttgtttctg cttttgctgc   1920

tcttgatccc acctttgctc ctgacaaccc tcattcaata aagaccagtg aagaccaaaa   1980

aaaaaaaaaa aaaaaa                                                   1996


<210>  1225
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  1225

Met Ala His Cys Val Thr Leu Val Gln Leu Ser Ile Ser Cys Asp His 
1               5                   10                  15


Leu Ile Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val Leu 
            20                  25                  30


Leu Gln Asp Val Gly Gly Gly Ser Trp Ala Glu Leu Gly Arg Thr Glu 
        35                  40                  45


Arg Val Arg Asn Cys Ser Ser Pro Glu Phe Ser Lys Thr Leu Gln Leu 
    50                  55                  60


Glu Tyr Arg Phe Glu Thr Val Gln Lys Leu Arg Phe Gly Ile Tyr Asp 
65                  70                  75                  80


Ile Asp Asn Lys Thr Pro Glu Leu Arg Asp Asp Asp Phe Leu Gly Gly 
                85                  90                  95


Ala Glu Cys Ser Leu Gly Gln Ile Val Ser Ser Gln Val Leu Thr Leu 
            100                 105                 110


Pro Leu Met Leu Lys Pro Gly Lys Pro Ala Gly Arg Gly Thr Ile Thr 
        115                 120                 125


Val Ser Ala Gln Glu Leu Lys Asp Asn Arg Val Val Thr Met Glu Val 
    130                 135                 140


Glu Ala Arg Asn Leu Asp Lys Lys Asp Phe Leu Gly Lys Ser Asp Pro 
145                 150                 155                 160


Phe Leu Glu Phe Phe Arg Gln Gly Asp Gly Lys Trp His Leu Val Tyr 
                165                 170                 175


Arg Ser Glu Val Ile Lys Asn Asn Leu Asn Pro Thr Trp Lys Arg Phe 
            180                 185                 190


Ser Val Pro Val Gln His Phe Cys Gly Gly Asn Pro Ser Thr Pro Ile 
        195                 200                 205


Gln Val Gln Cys Ser Asp Tyr Asp Ser Asp Gly Ser His Asp Leu Ile 
    210                 215                 220


Gly Thr Phe His Thr Ser Leu Ala Gln Leu Gln Ala Val Pro Ala Glu 
225                 230                 235                 240


Phe Glu Cys Ile His Pro Glu Lys Gln Gln Lys Lys Lys Ser Tyr Lys 
                245                 250                 255


Asn Ser Gly Thr Ile Arg Val Lys Ile Cys Arg Val Glu Thr Glu Tyr 
            260                 265                 270


Ser Phe Leu Asp Tyr Val Met Gly Gly Cys Gln Ile Asn Phe Thr Val 
        275                 280                 285


Gly Val Asp Phe Thr Gly Ser Asn Gly Asp Pro Ser Ser Pro Asp Ser 
    290                 295                 300


Leu His Tyr Leu Ser Pro Thr Gly Val Asn Glu Tyr Leu Met Ala Leu 
305                 310                 315                 320


Trp Ser Val Gly Ser Val Val Gln Asp Tyr Asp Ser Asp Lys Leu Phe 
                325                 330                 335


Pro Ala Phe Gly Phe Gly Ala Gln Val Pro Pro Asp Trp Gln Val Ser 
            340                 345                 350


His Glu Phe Ala Leu Asn Phe Asn Pro Ser Asn Pro Tyr Cys Ala Gly 
        355                 360                 365


Ile Gln Gly Ile Val Asp Ala Tyr Arg Gln Ala Leu Pro Gln Val Arg 
    370                 375                 380


Leu Tyr Gly Pro Thr Asn Phe Ala Pro Ile Ile Asn His Val Ala Arg 
385                 390                 395                 400


Phe Ala Ala Gln Ala Ala His Gln Gly Thr Ala Ser Gln Tyr Phe Met 
                405                 410                 415


Leu Leu Leu Leu Thr Asp Gly Ala Val Thr Asp Val Glu Ala Thr Arg 
            420                 425                 430


Glu Ala Val Val Arg Ala Ser Asn Leu Pro Met Ser Val Ile Ile Val 
        435                 440                 445


Gly Val Gly Gly Ala Asp Phe Glu Ala Met Glu Gln Leu Asp Ala Asp 
    450                 455                 460


Gly Gly Pro Leu His Thr Arg Ser Gly Gln Ala Ala Ala Arg Asp Ile 
465                 470                 475                 480


Val Gln Phe Val Pro Tyr Arg Arg Phe Gln Asn Ala Pro Arg Glu Ala 
                485                 490                 495


Leu Ala Gln Thr Val Leu Ala Glu Val Pro Thr Gln Leu Val Ser Tyr 
            500                 505                 510


Phe Arg Ala Gln Gly Trp Ala Pro Leu Lys Pro Leu Pro Pro Ser Ala 
        515                 520                 525


Lys Asp Pro Ala Gln Ala Pro Gln Ala 
    530                 535


<210>  1226
<211>  1954
<212>  DNA
<213>  Homo sapiens

<400>  1226
cggagccgct gagcgggccg acggccattt tgtgaagcgg cgaaggaggt ggtggctgcg     60

ttgggctccg ggaagccgtt cgggctgggg ctgtcggccg cggggcggag gcactcgcgc    120

gggggatggc ccactgcgtg accttggttc agctgtccat ttcctgtgac catctcattg    180

acaaggacat cggctccaag tctgacccac tctgcgtcct tttacaggat gtgggagggg    240

gcagctgggc tgagcttggc cggactgaac gggtgcggaa ctgctcaagc cctgagttct    300

ccaagactct acagcttgag taccgctttg agacagtcca gaagctacgc tttggaatct    360

atgacataga caacaagacg ccagagctga gggatgatga cttcctaggg ggtgctgagt    420

gttccctagg acagattgtg tccagccagg tactgactct ccccttgatg ctgaagcctg    480

gaaaacctgc tgggcggggg accatcacgg tctcagctca ggaattaaag gacaatcgtg    540

tagtaaccat ggaggtagag gccagaaacc tagataagaa ggacttcctg ggaaaatcag    600

atccatttct ggagttcttc cgccagggtg atgggaaatg gcacctggtg tacagatctg    660

aggtcatcaa gaacaacctg aaccctacat ggaagcgttt ctcagtcccc gttcagcatt    720

tctgtggtgg gaaccccagc acacccatcc aggtgcaatg ctccgattat gacagtgacg    780

ggtcacatga tctcatcggt accttccaca ccagcttggc ccagctgcag gcagtcccgg    840

ctgagtttga atgcatccac cctgagaagc agcagaaaaa gaaaagctac aagaactctg    900

gaactatccg tgtcaagatt tgtcgggtag aaacagagta ctcctttctg gactatgtga    960

tgggaggctg tcagatcaac ttcactgtgg gcgtggactt cactggctcc aatggagacc   1020

cctcctcacc tgactcccta cactacctga gtccaacagg ggtcaatgag tacctgatgg   1080

cactgtggag tgtgggcagc gtggttcagg actatgactc agacaagctg ttccctgcat   1140

ttggatttgg ggcccaggtt ccccctgact ggcaggtctc gcatgaattt gccttgaatt   1200

tcaaccccag taacccctac tgtgcaggca tccagggcat tgtggatgcc taccgccaag   1260

ccctgcccca agttcgcctc tatggcccta ccaactttgc acccatcatc aaccatgtgg   1320

ccaggtttgc agcccaggct gcacatcagg ggactgcctc gcaatacttc atgctgttgc   1380

tgctgactga tggtgctgtg acggatgtgg aagccacacg tgaggctgtg gtgcgtgcct   1440

cgaacctgcc catgtcagtg atcattgtgg gtgtgggtgg tgctgacttt gaggccatgg   1500

agcagctgga cgctgatggt ggacccctgc atacacgttc tgggcaggct gctgcccgcg   1560

acattgtgca gtttgtaccc taccgccggt tccagaatgc ccctcgggag gcattggcac   1620

agaccgtgct cgcagaagtg cccacacaac tggtctcata cttcagggcc cagggttggg   1680

ccccgctcaa gccacttcca ccctcagcca aggatcctgc acaggccccc caggcctagg   1740

ttcccttgga ggctgtggca agtcctcaat cctgtgtccc agaggtccct ctgggccaca   1800

acccaaccct tctcactctc ctcagtgcta gcactttgta ttttttgata cttttatact   1860

tgtttctgct tttgctgctc ttgatcccac ctttgctcct gacaaccctc attcaataaa   1920

gaccagtgaa gaccaaaaaa aaaaaaaaaa aaaa                               1954


<210>  1227
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  1227

Met Ala His Cys Val Thr Leu Val Gln Leu Ser Ile Ser Cys Asp His 
1               5                   10                  15


Leu Ile Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val Leu 
            20                  25                  30


Leu Gln Asp Val Gly Gly Gly Ser Trp Ala Glu Leu Gly Arg Thr Glu 
        35                  40                  45


Arg Val Arg Asn Cys Ser Ser Pro Glu Phe Ser Lys Thr Leu Gln Leu 
    50                  55                  60


Glu Tyr Arg Phe Glu Thr Val Gln Lys Leu Arg Phe Gly Ile Tyr Asp 
65                  70                  75                  80


Ile Asp Asn Lys Thr Pro Glu Leu Arg Asp Asp Asp Phe Leu Gly Gly 
                85                  90                  95


Ala Glu Cys Ser Leu Gly Gln Ile Val Ser Ser Gln Val Leu Thr Leu 
            100                 105                 110


Pro Leu Met Leu Lys Pro Gly Lys Pro Ala Gly Arg Gly Thr Ile Thr 
        115                 120                 125


Val Ser Ala Gln Glu Leu Lys Asp Asn Arg Val Val Thr Met Glu Val 
    130                 135                 140


Glu Ala Arg Asn Leu Asp Lys Lys Asp Phe Leu Gly Lys Ser Asp Pro 
145                 150                 155                 160


Phe Leu Glu Phe Phe Arg Gln Gly Asp Gly Lys Trp His Leu Val Tyr 
                165                 170                 175


Arg Ser Glu Val Ile Lys Asn Asn Leu Asn Pro Thr Trp Lys Arg Phe 
            180                 185                 190


Ser Val Pro Val Gln His Phe Cys Gly Gly Asn Pro Ser Thr Pro Ile 
        195                 200                 205


Gln Val Gln Cys Ser Asp Tyr Asp Ser Asp Gly Ser His Asp Leu Ile 
    210                 215                 220


Gly Thr Phe His Thr Ser Leu Ala Gln Leu Gln Ala Val Pro Ala Glu 
225                 230                 235                 240


Phe Glu Cys Ile His Pro Glu Lys Gln Gln Lys Lys Lys Ser Tyr Lys 
                245                 250                 255


Asn Ser Gly Thr Ile Arg Val Lys Ile Cys Arg Val Glu Thr Glu Tyr 
            260                 265                 270


Ser Phe Leu Asp Tyr Val Met Gly Gly Cys Gln Ile Asn Phe Thr Val 
        275                 280                 285


Gly Val Asp Phe Thr Gly Ser Asn Gly Asp Pro Ser Ser Pro Asp Ser 
    290                 295                 300


Leu His Tyr Leu Ser Pro Thr Gly Val Asn Glu Tyr Leu Met Ala Leu 
305                 310                 315                 320


Trp Ser Val Gly Ser Val Val Gln Asp Tyr Asp Ser Asp Lys Leu Phe 
                325                 330                 335


Pro Ala Phe Gly Phe Gly Ala Gln Val Pro Pro Asp Trp Gln Val Ser 
            340                 345                 350


His Glu Phe Ala Leu Asn Phe Asn Pro Ser Asn Pro Tyr Cys Ala Gly 
        355                 360                 365


Ile Gln Gly Ile Val Asp Ala Tyr Arg Gln Ala Leu Pro Gln Val Arg 
    370                 375                 380


Leu Tyr Gly Pro Thr Asn Phe Ala Pro Ile Ile Asn His Val Ala Arg 
385                 390                 395                 400


Phe Ala Ala Gln Ala Ala His Gln Gly Thr Ala Ser Gln Tyr Phe Met 
                405                 410                 415


Leu Leu Leu Leu Thr Asp Gly Ala Val Thr Asp Val Glu Ala Thr Arg 
            420                 425                 430


Glu Ala Val Val Arg Ala Ser Asn Leu Pro Met Ser Val Ile Ile Val 
        435                 440                 445


Gly Val Gly Gly Ala Asp Phe Glu Ala Met Glu Gln Leu Asp Ala Asp 
    450                 455                 460


Gly Gly Pro Leu His Thr Arg Ser Gly Gln Ala Ala Ala Arg Asp Ile 
465                 470                 475                 480


Val Gln Phe Val Pro Tyr Arg Arg Phe Gln Asn Ala Pro Arg Glu Ala 
                485                 490                 495


Leu Ala Gln Thr Val Leu Ala Glu Val Pro Thr Gln Leu Val Ser Tyr 
            500                 505                 510


Phe Arg Ala Gln Gly Trp Ala Pro Leu Lys Pro Leu Pro Pro Ser Ala 
        515                 520                 525


Lys Asp Pro Ala Gln Ala Pro Gln Ala 
    530                 535


<210>  1228
<211>  2081
<212>  DNA
<213>  Homo sapiens

<400>  1228
cggagccgct gagcgggccg acggccattt tgtgaagcgg cgaaggaggt ggtggctgcg     60

ttgggctccg ggaagccgtt cgggctgggg ctgtcggccg cggggcggag gcactcgcgc    120

ggggggtaat tcggggtctg ggttctggtg ccgcgcagct ttccccgtct aaaagttggt    180

tttaattggt tgcccacagg attgacttgg cctctacttc ttgttaagga aattcatctc    240

ttgttttatc agatggccca ctgcgtgacc ttggttcagc tgtccatttc ctgtgaccat    300

ctcattgaca aggacatcgg ctccaagtct gacccactct gcgtcctttt acaggatgtg    360

ggagggggca gctgggctga gcttggccgg actgaacggg tgcggaactg ctcaagccct    420

gagttctcca agactctaca gcttgagtac cgctttgaga cagtccagaa gctacgcttt    480

ggaatctatg acatagacaa caagacgcca gagctgaggg atgatgactt cctagggggt    540

gctgagtgtt ccctaggaca gattgtgtcc agccaggtac tgactctccc cttgatgctg    600

aagcctggaa aacctgctgg gcgggggacc atcacggtct cagctcagga attaaaggac    660

aatcgtgtag taaccatgga ggtagaggcc agaaacctag ataagaagga cttcctggga    720

aaatcagatc catttctgga gttcttccgc cagggtgatg ggaaatggca cctggtgtac    780

agatctgagg tcatcaagaa caacctgaac cctacatgga agcgtttctc agtccccgtt    840

cagcatttct gtggtgggaa ccccagcaca cccatccagg tgcaatgctc cgattatgac    900

agtgacgggt cacatgatct catcggtacc ttccacacca gcttggccca gctgcaggca    960

gtcccggctg agtttgaatg catccaccct gagaagcagc agaaaaagaa aagctacaag   1020

aactctggaa ctatccgtgt caagatttgt cgggtagaaa cagagtactc ctttctggac   1080

tatgtgatgg gaggctgtca gatcaacttc actgtgggcg tggacttcac tggctccaat   1140

ggagacccct cctcacctga ctccctacac tacctgagtc caacaggggt caatgagtac   1200

ctgatggcac tgtggagtgt gggcagcgtg gttcaggact atgactcaga caagctgttc   1260

cctgcatttg gatttggggc ccaggttccc cctgactggc aggtctcgca tgaatttgcc   1320

ttgaatttca accccagtaa cccctactgt gcaggcatcc agggcattgt ggatgcctac   1380

cgccaagccc tgccccaagt tcgcctctat ggccctacca actttgcacc catcatcaac   1440

catgtggcca ggtttgcagc ccaggctgca catcagggga ctgcctcgca atacttcatg   1500

ctgttgctgc tgactgatgg tgctgtgacg gatgtggaag ccacacgtga ggctgtggtg   1560

cgtgcctcga acctgcccat gtcagtgatc attgtgggtg tgggtggtgc tgactttgag   1620

gccatggagc agctggacgc tgatggtgga cccctgcata cacgttctgg gcaggctgct   1680

gcccgcgaca ttgtgcagtt tgtaccctac cgccggttcc agaatgcccc tcgggaggca   1740

ttggcacaga ccgtgctcgc agaagtgccc acacaactgg tctcatactt cagggcccag   1800

ggttgggccc cgctcaagcc acttccaccc tcagccaagg atcctgcaca ggccccccag   1860

gcctaggttc ccttggaggc tgtggcaagt cctcaatcct gtgtcccaga ggtccctctg   1920

ggccacaacc caacccttct cactctcctc agtgctagca ctttgtattt tttgatactt   1980

ttatacttgt ttctgctttt gctgctcttg atcccacctt tgctcctgac aaccctcatt   2040

caataaagac cagtgaagac caaaaaaaaa aaaaaaaaaa a                       2081


<210>  1229
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  1229

Met Ala His Cys Val Thr Leu Val Gln Leu Ser Ile Ser Cys Asp His 
1               5                   10                  15


Leu Ile Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val Leu 
            20                  25                  30


Leu Gln Asp Val Gly Gly Gly Ser Trp Ala Glu Leu Gly Arg Thr Glu 
        35                  40                  45


Arg Val Arg Asn Cys Ser Ser Pro Glu Phe Ser Lys Thr Leu Gln Leu 
    50                  55                  60


Glu Tyr Arg Phe Glu Thr Val Gln Lys Leu Arg Phe Gly Ile Tyr Asp 
65                  70                  75                  80


Ile Asp Asn Lys Thr Pro Glu Leu Arg Asp Asp Asp Phe Leu Gly Gly 
                85                  90                  95


Ala Glu Cys Ser Leu Gly Gln Ile Val Ser Ser Gln Val Leu Thr Leu 
            100                 105                 110


Pro Leu Met Leu Lys Pro Gly Lys Pro Ala Gly Arg Gly Thr Ile Thr 
        115                 120                 125


Val Ser Ala Gln Glu Leu Lys Asp Asn Arg Val Val Thr Met Glu Val 
    130                 135                 140


Glu Ala Arg Asn Leu Asp Lys Lys Asp Phe Leu Gly Lys Ser Asp Pro 
145                 150                 155                 160


Phe Leu Glu Phe Phe Arg Gln Gly Asp Gly Lys Trp His Leu Val Tyr 
                165                 170                 175


Arg Ser Glu Val Ile Lys Asn Asn Leu Asn Pro Thr Trp Lys Arg Phe 
            180                 185                 190


Ser Val Pro Val Gln His Phe Cys Gly Gly Asn Pro Ser Thr Pro Ile 
        195                 200                 205


Gln Val Gln Cys Ser Asp Tyr Asp Ser Asp Gly Ser His Asp Leu Ile 
    210                 215                 220


Gly Thr Phe His Thr Ser Leu Ala Gln Leu Gln Ala Val Pro Ala Glu 
225                 230                 235                 240


Phe Glu Cys Ile His Pro Glu Lys Gln Gln Lys Lys Lys Ser Tyr Lys 
                245                 250                 255


Asn Ser Gly Thr Ile Arg Val Lys Ile Cys Arg Val Glu Thr Glu Tyr 
            260                 265                 270


Ser Phe Leu Asp Tyr Val Met Gly Gly Cys Gln Ile Asn Phe Thr Val 
        275                 280                 285


Gly Val Asp Phe Thr Gly Ser Asn Gly Asp Pro Ser Ser Pro Asp Ser 
    290                 295                 300


Leu His Tyr Leu Ser Pro Thr Gly Val Asn Glu Tyr Leu Met Ala Leu 
305                 310                 315                 320


Trp Ser Val Gly Ser Val Val Gln Asp Tyr Asp Ser Asp Lys Leu Phe 
                325                 330                 335


Pro Ala Phe Gly Phe Gly Ala Gln Val Pro Pro Asp Trp Gln Val Ser 
            340                 345                 350


His Glu Phe Ala Leu Asn Phe Asn Pro Ser Asn Pro Tyr Cys Ala Gly 
        355                 360                 365


Ile Gln Gly Ile Val Asp Ala Tyr Arg Gln Ala Leu Pro Gln Val Arg 
    370                 375                 380


Leu Tyr Gly Pro Thr Asn Phe Ala Pro Ile Ile Asn His Val Ala Arg 
385                 390                 395                 400


Phe Ala Ala Gln Ala Ala His Gln Gly Thr Ala Ser Gln Tyr Phe Met 
                405                 410                 415


Leu Leu Leu Leu Thr Asp Gly Ala Val Thr Asp Val Glu Ala Thr Arg 
            420                 425                 430


Glu Ala Val Val Arg Ala Ser Asn Leu Pro Met Ser Val Ile Ile Val 
        435                 440                 445


Gly Val Gly Gly Ala Asp Phe Glu Ala Met Glu Gln Leu Asp Ala Asp 
    450                 455                 460


Gly Gly Pro Leu His Thr Arg Ser Gly Gln Ala Ala Ala Arg Asp Ile 
465                 470                 475                 480


Val Gln Phe Val Pro Tyr Arg Arg Phe Gln Asn Ala Pro Arg Glu Ala 
                485                 490                 495


Leu Ala Gln Thr Val Leu Ala Glu Val Pro Thr Gln Leu Val Ser Tyr 
            500                 505                 510


Phe Arg Ala Gln Gly Trp Ala Pro Leu Lys Pro Leu Pro Pro Ser Ala 
        515                 520                 525


Lys Asp Pro Ala Gln Ala Pro Gln Ala 
    530                 535


<210>  1230
<211>  2049
<212>  DNA
<213>  Homo sapiens

<400>  1230
cggagccgct gagcgggccg acggccattt tgtgaagcgg cgaaggaggt ggtggctgcg     60

ttgggctccg ggaagccgtt cgggctgggg ctgtcggccg cggggcggag gcactcgcgc    120

ggggggtaat tcggggtctg ggttctggtg ccgcgcagct ttccccggat tgacttggcc    180

tctacttctt gttaaggaaa ttcatctctt gttttatcag atggcccact gcgtgacctt    240

ggttcagctg tccatttcct gtgaccatct cattgacaag gacatcggct ccaagtctga    300

cccactctgc gtccttttac aggatgtggg agggggcagc tgggctgagc ttggccggac    360

tgaacgggtg cggaactgct caagccctga gttctccaag actctacagc ttgagtaccg    420

ctttgagaca gtccagaagc tacgctttgg aatctatgac atagacaaca agacgccaga    480

gctgagggat gatgacttcc tagggggtgc tgagtgttcc ctaggacaga ttgtgtccag    540

ccaggtactg actctcccct tgatgctgaa gcctggaaaa cctgctgggc gggggaccat    600

cacggtctca gctcaggaat taaaggacaa tcgtgtagta accatggagg tagaggccag    660

aaacctagat aagaaggact tcctgggaaa atcagatcca tttctggagt tcttccgcca    720

gggtgatggg aaatggcacc tggtgtacag atctgaggtc atcaagaaca acctgaaccc    780

tacatggaag cgtttctcag tccccgttca gcatttctgt ggtgggaacc ccagcacacc    840

catccaggtg caatgctccg attatgacag tgacgggtca catgatctca tcggtacctt    900

ccacaccagc ttggcccagc tgcaggcagt cccggctgag tttgaatgca tccaccctga    960

gaagcagcag aaaaagaaaa gctacaagaa ctctggaact atccgtgtca agatttgtcg   1020

ggtagaaaca gagtactcct ttctggacta tgtgatggga ggctgtcaga tcaacttcac   1080

tgtgggcgtg gacttcactg gctccaatgg agacccctcc tcacctgact ccctacacta   1140

cctgagtcca acaggggtca atgagtacct gatggcactg tggagtgtgg gcagcgtggt   1200

tcaggactat gactcagaca agctgttccc tgcatttgga tttggggccc aggttccccc   1260

tgactggcag gtctcgcatg aatttgcctt gaatttcaac cccagtaacc cctactgtgc   1320

aggcatccag ggcattgtgg atgcctaccg ccaagccctg ccccaagttc gcctctatgg   1380

ccctaccaac tttgcaccca tcatcaacca tgtggccagg tttgcagccc aggctgcaca   1440

tcaggggact gcctcgcaat acttcatgct gttgctgctg actgatggtg ctgtgacgga   1500

tgtggaagcc acacgtgagg ctgtggtgcg tgcctcgaac ctgcccatgt cagtgatcat   1560

tgtgggtgtg ggtggtgctg actttgaggc catggagcag ctggacgctg atggtggacc   1620

cctgcataca cgttctgggc aggctgctgc ccgcgacatt gtgcagtttg taccctaccg   1680

ccggttccag aatgcccctc gggaggcatt ggcacagacc gtgctcgcag aagtgcccac   1740

acaactggtc tcatacttca gggcccaggg ttgggccccg ctcaagccac ttccaccctc   1800

agccaaggat cctgcacagg ccccccaggc ctaggttccc ttggaggctg tggcaagtcc   1860

tcaatcctgt gtcccagagg tccctctggg ccacaaccca acccttctca ctctcctcag   1920

tgctagcact ttgtattttt tgatactttt atacttgttt ctgcttttgc tgctcttgat   1980

cccacctttg ctcctgacaa ccctcattca ataaagacca gtgaagacca aaaaaaaaaa   2040

aaaaaaaaa                                                           2049


<210>  1231
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  1231

Met Ala His Cys Val Thr Leu Val Gln Leu Ser Ile Ser Cys Asp His 
1               5                   10                  15


Leu Ile Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val Leu 
            20                  25                  30


Leu Gln Asp Val Gly Gly Gly Ser Trp Ala Glu Leu Gly Arg Thr Glu 
        35                  40                  45


Arg Val Arg Asn Cys Ser Ser Pro Glu Phe Ser Lys Thr Leu Gln Leu 
    50                  55                  60


Glu Tyr Arg Phe Glu Thr Val Gln Lys Leu Arg Phe Gly Ile Tyr Asp 
65                  70                  75                  80


Ile Asp Asn Lys Thr Pro Glu Leu Arg Asp Asp Asp Phe Leu Gly Gly 
                85                  90                  95


Ala Glu Cys Ser Leu Gly Gln Ile Val Ser Ser Gln Val Leu Thr Leu 
            100                 105                 110


Pro Leu Met Leu Lys Pro Gly Lys Pro Ala Gly Arg Gly Thr Ile Thr 
        115                 120                 125


Val Ser Ala Gln Glu Leu Lys Asp Asn Arg Val Val Thr Met Glu Val 
    130                 135                 140


Glu Ala Arg Asn Leu Asp Lys Lys Asp Phe Leu Gly Lys Ser Asp Pro 
145                 150                 155                 160


Phe Leu Glu Phe Phe Arg Gln Gly Asp Gly Lys Trp His Leu Val Tyr 
                165                 170                 175


Arg Ser Glu Val Ile Lys Asn Asn Leu Asn Pro Thr Trp Lys Arg Phe 
            180                 185                 190


Ser Val Pro Val Gln His Phe Cys Gly Gly Asn Pro Ser Thr Pro Ile 
        195                 200                 205


Gln Val Gln Cys Ser Asp Tyr Asp Ser Asp Gly Ser His Asp Leu Ile 
    210                 215                 220


Gly Thr Phe His Thr Ser Leu Ala Gln Leu Gln Ala Val Pro Ala Glu 
225                 230                 235                 240


Phe Glu Cys Ile His Pro Glu Lys Gln Gln Lys Lys Lys Ser Tyr Lys 
                245                 250                 255


Asn Ser Gly Thr Ile Arg Val Lys Ile Cys Arg Val Glu Thr Glu Tyr 
            260                 265                 270


Ser Phe Leu Asp Tyr Val Met Gly Gly Cys Gln Ile Asn Phe Thr Val 
        275                 280                 285


Gly Val Asp Phe Thr Gly Ser Asn Gly Asp Pro Ser Ser Pro Asp Ser 
    290                 295                 300


Leu His Tyr Leu Ser Pro Thr Gly Val Asn Glu Tyr Leu Met Ala Leu 
305                 310                 315                 320


Trp Ser Val Gly Ser Val Val Gln Asp Tyr Asp Ser Asp Lys Leu Phe 
                325                 330                 335


Pro Ala Phe Gly Phe Gly Ala Gln Val Pro Pro Asp Trp Gln Val Ser 
            340                 345                 350


His Glu Phe Ala Leu Asn Phe Asn Pro Ser Asn Pro Tyr Cys Ala Gly 
        355                 360                 365


Ile Gln Gly Ile Val Asp Ala Tyr Arg Gln Ala Leu Pro Gln Val Arg 
    370                 375                 380


Leu Tyr Gly Pro Thr Asn Phe Ala Pro Ile Ile Asn His Val Ala Arg 
385                 390                 395                 400


Phe Ala Ala Gln Ala Ala His Gln Gly Thr Ala Ser Gln Tyr Phe Met 
                405                 410                 415


Leu Leu Leu Leu Thr Asp Gly Ala Val Thr Asp Val Glu Ala Thr Arg 
            420                 425                 430


Glu Ala Val Val Arg Ala Ser Asn Leu Pro Met Ser Val Ile Ile Val 
        435                 440                 445


Gly Val Gly Gly Ala Asp Phe Glu Ala Met Glu Gln Leu Asp Ala Asp 
    450                 455                 460


Gly Gly Pro Leu His Thr Arg Ser Gly Gln Ala Ala Ala Arg Asp Ile 
465                 470                 475                 480


Val Gln Phe Val Pro Tyr Arg Arg Phe Gln Asn Ala Pro Arg Glu Ala 
                485                 490                 495


Leu Ala Gln Thr Val Leu Ala Glu Val Pro Thr Gln Leu Val Ser Tyr 
            500                 505                 510


Phe Arg Ala Gln Gly Trp Ala Pro Leu Lys Pro Leu Pro Pro Ser Ala 
        515                 520                 525


Lys Asp Pro Ala Gln Ala Pro Gln Ala 
    530                 535


<210>  1232
<211>  2097
<212>  DNA
<213>  Homo sapiens

<400>  1232
cggagccgct gagcgggccg acggccattt tgtgaagcgg cgaaggaggt ggtggctgcg     60

ttgggctccg ggaagccgtt cgggctgggg ctgtcggccg cggggcggag gcactcgcgc    120

ggggggtgtg tgtggtttca gcgcagcatg gctgtggtca tccgtttgca aggtctccca    180

attgtggcgg ggaccatgga cattcgccac ttcttctctg gattgaccat tcctgatggg    240

ggcgtgcata ttgtaggggg tgaactggat ggcccactgc gtgaccttgg ttcagctgtc    300

catttcctgt gaccatctca ttgacaagga catcggctcc aagtctgacc cactctgcgt    360

ccttttacag gatgtgggag ggggcagctg ggctgagctt ggccggactg aacgggtgcg    420

gaactgctca agccctgagt tctccaagac tctacagctt gagtaccgct ttgagacagt    480

ccagaagcta cgctttggaa tctatgacat agacaacaag acgccagagc tgagggatga    540

tgacttccta gggggtgctg agtgttccct aggacagatt gtgtccagcc aggtactgac    600

tctccccttg atgctgaagc ctggaaaacc tgctgggcgg gggaccatca cggtctcagc    660

tcaggaatta aaggacaatc gtgtagtaac catggaggta gaggccagaa acctagataa    720

gaaggacttc ctgggaaaat cagatccatt tctggagttc ttccgccagg gtgatgggaa    780

atggcacctg gtgtacagat ctgaggtcat caagaacaac ctgaacccta catggaagcg    840

tttctcagtc cccgttcagc atttctgtgg tgggaacccc agcacaccca tccaggtgca    900

atgctccgat tatgacagtg acgggtcaca tgatctcatc ggtaccttcc acaccagctt    960

ggcccagctg caggcagtcc cggctgagtt tgaatgcatc caccctgaga agcagcagaa   1020

aaagaaaagc tacaagaact ctggaactat ccgtgtcaag atttgtcggg tagaaacaga   1080

gtactccttt ctggactatg tgatgggagg ctgtcagatc aacttcactg tgggcgtgga   1140

cttcactggc tccaatggag acccctcctc acctgactcc ctacactacc tgagtccaac   1200

aggggtcaat gagtacctga tggcactgtg gagtgtgggc agcgtggttc aggactatga   1260

ctcagacaag ctgttccctg catttggatt tggggcccag gttccccctg actggcaggt   1320

ctcgcatgaa tttgccttga atttcaaccc cagtaacccc tactgtgcag gcatccaggg   1380

cattgtggat gcctaccgcc aagccctgcc ccaagttcgc ctctatggcc ctaccaactt   1440

tgcacccatc atcaaccatg tggccaggtt tgcagcccag gctgcacatc aggggactgc   1500

ctcgcaatac ttcatgctgt tgctgctgac tgatggtgct gtgacggatg tggaagccac   1560

acgtgaggct gtggtgcgtg cctcgaacct gcccatgtca gtgatcattg tgggtgtggg   1620

tggtgctgac tttgaggcca tggagcagct ggacgctgat ggtggacccc tgcatacacg   1680

ttctgggcag gctgctgccc gcgacattgt gcagtttgta ccctaccgcc ggttccagaa   1740

tgcccctcgg gaggcattgg cacagaccgt gctcgcagaa gtgcccacac aactggtctc   1800

atacttcagg gcccagggtt gggccccgct caagccactt ccaccctcag ccaaggatcc   1860

tgcacaggcc ccccaggcct aggttccctt ggaggctgtg gcaagtcctc aatcctgtgt   1920

cccagaggtc cctctgggcc acaacccaac ccttctcact ctcctcagtg ctagcacttt   1980

gtattttttg atacttttat acttgtttct gcttttgctg ctcttgatcc cacctttgct   2040

cctgacaacc ctcattcaat aaagaccagt gaagaccaaa aaaaaaaaaa aaaaaaa      2097


<210>  1233
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  1233

Met Ala His Cys Val Thr Leu Val Gln Leu Ser Ile Ser Cys Asp His 
1               5                   10                  15


Leu Ile Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val Leu 
            20                  25                  30


Leu Gln Asp Val Gly Gly Gly Ser Trp Ala Glu Leu Gly Arg Thr Glu 
        35                  40                  45


Arg Val Arg Asn Cys Ser Ser Pro Glu Phe Ser Lys Thr Leu Gln Leu 
    50                  55                  60


Glu Tyr Arg Phe Glu Thr Val Gln Lys Leu Arg Phe Gly Ile Tyr Asp 
65                  70                  75                  80


Ile Asp Asn Lys Thr Pro Glu Leu Arg Asp Asp Asp Phe Leu Gly Gly 
                85                  90                  95


Ala Glu Cys Ser Leu Gly Gln Ile Val Ser Ser Gln Val Leu Thr Leu 
            100                 105                 110


Pro Leu Met Leu Lys Pro Gly Lys Pro Ala Gly Arg Gly Thr Ile Thr 
        115                 120                 125


Val Ser Ala Gln Glu Leu Lys Asp Asn Arg Val Val Thr Met Glu Val 
    130                 135                 140


Glu Ala Arg Asn Leu Asp Lys Lys Asp Phe Leu Gly Lys Ser Asp Pro 
145                 150                 155                 160


Phe Leu Glu Phe Phe Arg Gln Gly Asp Gly Lys Trp His Leu Val Tyr 
                165                 170                 175


Arg Ser Glu Val Ile Lys Asn Asn Leu Asn Pro Thr Trp Lys Arg Phe 
            180                 185                 190


Ser Val Pro Val Gln His Phe Cys Gly Gly Asn Pro Ser Thr Pro Ile 
        195                 200                 205


Gln Val Gln Cys Ser Asp Tyr Asp Ser Asp Gly Ser His Asp Leu Ile 
    210                 215                 220


Gly Thr Phe His Thr Ser Leu Ala Gln Leu Gln Ala Val Pro Ala Glu 
225                 230                 235                 240


Phe Glu Cys Ile His Pro Glu Lys Gln Gln Lys Lys Lys Ser Tyr Lys 
                245                 250                 255


Asn Ser Gly Thr Ile Arg Val Lys Ile Cys Arg Val Glu Thr Glu Tyr 
            260                 265                 270


Ser Phe Leu Asp Tyr Val Met Gly Gly Cys Gln Ile Asn Phe Thr Val 
        275                 280                 285


Gly Val Asp Phe Thr Gly Ser Asn Gly Asp Pro Ser Ser Pro Asp Ser 
    290                 295                 300


Leu His Tyr Leu Ser Pro Thr Gly Val Asn Glu Tyr Leu Met Ala Leu 
305                 310                 315                 320


Trp Ser Val Gly Ser Val Val Gln Asp Tyr Asp Ser Asp Lys Leu Phe 
                325                 330                 335


Pro Ala Phe Gly Phe Gly Ala Gln Val Pro Pro Asp Trp Gln Val Ser 
            340                 345                 350


His Glu Phe Ala Leu Asn Phe Asn Pro Ser Asn Pro Tyr Cys Ala Gly 
        355                 360                 365


Ile Gln Gly Ile Val Asp Ala Tyr Arg Gln Ala Leu Pro Gln Val Arg 
    370                 375                 380


Leu Tyr Gly Pro Thr Asn Phe Ala Pro Ile Ile Asn His Val Ala Arg 
385                 390                 395                 400


Phe Ala Ala Gln Ala Ala His Gln Gly Thr Ala Ser Gln Tyr Phe Met 
                405                 410                 415


Leu Leu Leu Leu Thr Asp Gly Ala Val Thr Asp Val Glu Ala Thr Arg 
            420                 425                 430


Glu Ala Val Val Arg Ala Ser Asn Leu Pro Met Ser Val Ile Ile Val 
        435                 440                 445


Gly Val Gly Gly Ala Asp Phe Glu Ala Met Glu Gln Leu Asp Ala Asp 
    450                 455                 460


Gly Gly Pro Leu His Thr Arg Ser Gly Gln Ala Ala Ala Arg Asp Ile 
465                 470                 475                 480


Val Gln Phe Val Pro Tyr Arg Arg Phe Gln Asn Ala Pro Arg Glu Ala 
                485                 490                 495


Leu Ala Gln Thr Val Leu Ala Glu Val Pro Thr Gln Leu Val Ser Tyr 
            500                 505                 510


Phe Arg Ala Gln Gly Trp Ala Pro Leu Lys Pro Leu Pro Pro Ser Ala 
        515                 520                 525


Lys Asp Pro Ala Gln Ala Pro Gln Ala 
    530                 535


<210>  1234
<211>  2224
<212>  DNA
<213>  Homo sapiens

<400>  1234
cggagccgct gagcgggccg acggccattt tgtgaagcgg cgaaggaggt ggtggctgcg     60

ttgggctccg ggaagccgtt cgggctgggg ctgtcggccg cggggcggag gcactcgcgc    120

ggggggtaat tcggggtctg ggttctggtg ccgcgcagct ttccccgtct aaaagttggt    180

tttaattggt tgcccacagg attgacttgg cctctacttc ttgttaagga aattcatctc    240

ttgttttatc aggtgtgtgt ggtttcagcg cagcatggct gtggtcatcc gtttgcaagg    300

tctcccaatt gtggcgggga ccatggacat tcgccacttc ttctctggat tgaccattcc    360

tgatgggggc gtgcatattg tagggggtga actggatggc ccactgcgtg accttggttc    420

agctgtccat ttcctgtgac catctcattg acaaggacat cggctccaag tctgacccac    480

tctgcgtcct tttacaggat gtgggagggg gcagctgggc tgagcttggc cggactgaac    540

gggtgcggaa ctgctcaagc cctgagttct ccaagactct acagcttgag taccgctttg    600

agacagtcca gaagctacgc tttggaatct atgacataga caacaagacg ccagagctga    660

gggatgatga cttcctaggg ggtgctgagt gttccctagg acagattgtg tccagccagg    720

tactgactct ccccttgatg ctgaagcctg gaaaacctgc tgggcggggg accatcacgg    780

tctcagctca ggaattaaag gacaatcgtg tagtaaccat ggaggtagag gccagaaacc    840

tagataagaa ggacttcctg ggaaaatcag atccatttct ggagttcttc cgccagggtg    900

atgggaaatg gcacctggtg tacagatctg aggtcatcaa gaacaacctg aaccctacat    960

ggaagcgttt ctcagtcccc gttcagcatt tctgtggtgg gaaccccagc acacccatcc   1020

aggtgcaatg ctccgattat gacagtgacg ggtcacatga tctcatcggt accttccaca   1080

ccagcttggc ccagctgcag gcagtcccgg ctgagtttga atgcatccac cctgagaagc   1140

agcagaaaaa gaaaagctac aagaactctg gaactatccg tgtcaagatt tgtcgggtag   1200

aaacagagta ctcctttctg gactatgtga tgggaggctg tcagatcaac ttcactgtgg   1260

gcgtggactt cactggctcc aatggagacc cctcctcacc tgactcccta cactacctga   1320

gtccaacagg ggtcaatgag tacctgatgg cactgtggag tgtgggcagc gtggttcagg   1380

actatgactc agacaagctg ttccctgcat ttggatttgg ggcccaggtt ccccctgact   1440

ggcaggtctc gcatgaattt gccttgaatt tcaaccccag taacccctac tgtgcaggca   1500

tccagggcat tgtggatgcc taccgccaag ccctgcccca agttcgcctc tatggcccta   1560

ccaactttgc acccatcatc aaccatgtgg ccaggtttgc agcccaggct gcacatcagg   1620

ggactgcctc gcaatacttc atgctgttgc tgctgactga tggtgctgtg acggatgtgg   1680

aagccacacg tgaggctgtg gtgcgtgcct cgaacctgcc catgtcagtg atcattgtgg   1740

gtgtgggtgg tgctgacttt gaggccatgg agcagctgga cgctgatggt ggacccctgc   1800

atacacgttc tgggcaggct gctgcccgcg acattgtgca gtttgtaccc taccgccggt   1860

tccagaatgc ccctcgggag gcattggcac agaccgtgct cgcagaagtg cccacacaac   1920

tggtctcata cttcagggcc cagggttggg ccccgctcaa gccacttcca ccctcagcca   1980

aggatcctgc acaggccccc caggcctagg ttcccttgga ggctgtggca agtcctcaat   2040

cctgtgtccc agaggtccct ctgggccaca acccaaccct tctcactctc ctcagtgcta   2100

gcactttgta ttttttgata cttttatact tgtttctgct tttgctgctc ttgatcccac   2160

ctttgctcct gacaaccctc attcaataaa gaccagtgaa gaccaaaaaa aaaaaaaaaa   2220

aaaa                                                                2224


<210>  1235
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  1235

Met Ala His Cys Val Thr Leu Val Gln Leu Ser Ile Ser Cys Asp His 
1               5                   10                  15


Leu Ile Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val Leu 
            20                  25                  30


Leu Gln Asp Val Gly Gly Gly Ser Trp Ala Glu Leu Gly Arg Thr Glu 
        35                  40                  45


Arg Val Arg Asn Cys Ser Ser Pro Glu Phe Ser Lys Thr Leu Gln Leu 
    50                  55                  60


Glu Tyr Arg Phe Glu Thr Val Gln Lys Leu Arg Phe Gly Ile Tyr Asp 
65                  70                  75                  80


Ile Asp Asn Lys Thr Pro Glu Leu Arg Asp Asp Asp Phe Leu Gly Gly 
                85                  90                  95


Ala Glu Cys Ser Leu Gly Gln Ile Val Ser Ser Gln Val Leu Thr Leu 
            100                 105                 110


Pro Leu Met Leu Lys Pro Gly Lys Pro Ala Gly Arg Gly Thr Ile Thr 
        115                 120                 125


Val Ser Ala Gln Glu Leu Lys Asp Asn Arg Val Val Thr Met Glu Val 
    130                 135                 140


Glu Ala Arg Asn Leu Asp Lys Lys Asp Phe Leu Gly Lys Ser Asp Pro 
145                 150                 155                 160


Phe Leu Glu Phe Phe Arg Gln Gly Asp Gly Lys Trp His Leu Val Tyr 
                165                 170                 175


Arg Ser Glu Val Ile Lys Asn Asn Leu Asn Pro Thr Trp Lys Arg Phe 
            180                 185                 190


Ser Val Pro Val Gln His Phe Cys Gly Gly Asn Pro Ser Thr Pro Ile 
        195                 200                 205


Gln Val Gln Cys Ser Asp Tyr Asp Ser Asp Gly Ser His Asp Leu Ile 
    210                 215                 220


Gly Thr Phe His Thr Ser Leu Ala Gln Leu Gln Ala Val Pro Ala Glu 
225                 230                 235                 240


Phe Glu Cys Ile His Pro Glu Lys Gln Gln Lys Lys Lys Ser Tyr Lys 
                245                 250                 255


Asn Ser Gly Thr Ile Arg Val Lys Ile Cys Arg Val Glu Thr Glu Tyr 
            260                 265                 270


Ser Phe Leu Asp Tyr Val Met Gly Gly Cys Gln Ile Asn Phe Thr Val 
        275                 280                 285


Gly Val Asp Phe Thr Gly Ser Asn Gly Asp Pro Ser Ser Pro Asp Ser 
    290                 295                 300


Leu His Tyr Leu Ser Pro Thr Gly Val Asn Glu Tyr Leu Met Ala Leu 
305                 310                 315                 320


Trp Ser Val Gly Ser Val Val Gln Asp Tyr Asp Ser Asp Lys Leu Phe 
                325                 330                 335


Pro Ala Phe Gly Phe Gly Ala Gln Val Pro Pro Asp Trp Gln Val Ser 
            340                 345                 350


His Glu Phe Ala Leu Asn Phe Asn Pro Ser Asn Pro Tyr Cys Ala Gly 
        355                 360                 365


Ile Gln Gly Ile Val Asp Ala Tyr Arg Gln Ala Leu Pro Gln Val Arg 
    370                 375                 380


Leu Tyr Gly Pro Thr Asn Phe Ala Pro Ile Ile Asn His Val Ala Arg 
385                 390                 395                 400


Phe Ala Ala Gln Ala Ala His Gln Gly Thr Ala Ser Gln Tyr Phe Met 
                405                 410                 415


Leu Leu Leu Leu Thr Asp Gly Ala Val Thr Asp Val Glu Ala Thr Arg 
            420                 425                 430


Glu Ala Val Val Arg Ala Ser Asn Leu Pro Met Ser Val Ile Ile Val 
        435                 440                 445


Gly Val Gly Gly Ala Asp Phe Glu Ala Met Glu Gln Leu Asp Ala Asp 
    450                 455                 460


Gly Gly Pro Leu His Thr Arg Ser Gly Gln Ala Ala Ala Arg Asp Ile 
465                 470                 475                 480


Val Gln Phe Val Pro Tyr Arg Arg Phe Gln Asn Ala Pro Arg Glu Ala 
                485                 490                 495


Leu Ala Gln Thr Val Leu Ala Glu Val Pro Thr Gln Leu Val Ser Tyr 
            500                 505                 510


Phe Arg Ala Gln Gly Trp Ala Pro Leu Lys Pro Leu Pro Pro Ser Ala 
        515                 520                 525


Lys Asp Pro Ala Gln Ala Pro Gln Ala 
    530                 535


<210>  1236
<211>  2192
<212>  DNA
<213>  Homo sapiens

<400>  1236
cggagccgct gagcgggccg acggccattt tgtgaagcgg cgaaggaggt ggtggctgcg     60

ttgggctccg ggaagccgtt cgggctgggg ctgtcggccg cggggcggag gcactcgcgc    120

ggggggtaat tcggggtctg ggttctggtg ccgcgcagct ttccccggat tgacttggcc    180

tctacttctt gttaaggaaa ttcatctctt gttttatcag gtgtgtgtgg tttcagcgca    240

gcatggctgt ggtcatccgt ttgcaaggtc tcccaattgt ggcggggacc atggacattc    300

gccacttctt ctctggattg accattcctg atgggggcgt gcatattgta gggggtgaac    360

tggatggccc actgcgtgac cttggttcag ctgtccattt cctgtgacca tctcattgac    420

aaggacatcg gctccaagtc tgacccactc tgcgtccttt tacaggatgt gggagggggc    480

agctgggctg agcttggccg gactgaacgg gtgcggaact gctcaagccc tgagttctcc    540

aagactctac agcttgagta ccgctttgag acagtccaga agctacgctt tggaatctat    600

gacatagaca acaagacgcc agagctgagg gatgatgact tcctaggggg tgctgagtgt    660

tccctaggac agattgtgtc cagccaggta ctgactctcc ccttgatgct gaagcctgga    720

aaacctgctg ggcgggggac catcacggtc tcagctcagg aattaaagga caatcgtgta    780

gtaaccatgg aggtagaggc cagaaaccta gataagaagg acttcctggg aaaatcagat    840

ccatttctgg agttcttccg ccagggtgat gggaaatggc acctggtgta cagatctgag    900

gtcatcaaga acaacctgaa ccctacatgg aagcgtttct cagtccccgt tcagcatttc    960

tgtggtggga accccagcac acccatccag gtgcaatgct ccgattatga cagtgacggg   1020

tcacatgatc tcatcggtac cttccacacc agcttggccc agctgcaggc agtcccggct   1080

gagtttgaat gcatccaccc tgagaagcag cagaaaaaga aaagctacaa gaactctgga   1140

actatccgtg tcaagatttg tcgggtagaa acagagtact cctttctgga ctatgtgatg   1200

ggaggctgtc agatcaactt cactgtgggc gtggacttca ctggctccaa tggagacccc   1260

tcctcacctg actccctaca ctacctgagt ccaacagggg tcaatgagta cctgatggca   1320

ctgtggagtg tgggcagcgt ggttcaggac tatgactcag acaagctgtt ccctgcattt   1380

ggatttgggg cccaggttcc ccctgactgg caggtctcgc atgaatttgc cttgaatttc   1440

aaccccagta acccctactg tgcaggcatc cagggcattg tggatgccta ccgccaagcc   1500

ctgccccaag ttcgcctcta tggccctacc aactttgcac ccatcatcaa ccatgtggcc   1560

aggtttgcag cccaggctgc acatcagggg actgcctcgc aatacttcat gctgttgctg   1620

ctgactgatg gtgctgtgac ggatgtggaa gccacacgtg aggctgtggt gcgtgcctcg   1680

aacctgccca tgtcagtgat cattgtgggt gtgggtggtg ctgactttga ggccatggag   1740

cagctggacg ctgatggtgg acccctgcat acacgttctg ggcaggctgc tgcccgcgac   1800

attgtgcagt ttgtacccta ccgccggttc cagaatgccc ctcgggaggc attggcacag   1860

accgtgctcg cagaagtgcc cacacaactg gtctcatact tcagggccca gggttgggcc   1920

ccgctcaagc cacttccacc ctcagccaag gatcctgcac aggcccccca ggcctaggtt   1980

cccttggagg ctgtggcaag tcctcaatcc tgtgtcccag aggtccctct gggccacaac   2040

ccaacccttc tcactctcct cagtgctagc actttgtatt ttttgatact tttatacttg   2100

tttctgcttt tgctgctctt gatcccacct ttgctcctga caaccctcat tcaataaaga   2160

ccagtgaaga ccaaaaaaaa aaaaaaaaaa aa                                 2192


<210>  1237
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  1237

Met Ala His Cys Val Thr Leu Val Gln Leu Ser Ile Ser Cys Asp His 
1               5                   10                  15


Leu Ile Asp Lys Asp Ile Gly Ser Lys Ser Asp Pro Leu Cys Val Leu 
            20                  25                  30


Leu Gln Asp Val Gly Gly Gly Ser Trp Ala Glu Leu Gly Arg Thr Glu 
        35                  40                  45


Arg Val Arg Asn Cys Ser Ser Pro Glu Phe Ser Lys Thr Leu Gln Leu 
    50                  55                  60


Glu Tyr Arg Phe Glu Thr Val Gln Lys Leu Arg Phe Gly Ile Tyr Asp 
65                  70                  75                  80


Ile Asp Asn Lys Thr Pro Glu Leu Arg Asp Asp Asp Phe Leu Gly Gly 
                85                  90                  95


Ala Glu Cys Ser Leu Gly Gln Ile Val Ser Ser Gln Val Leu Thr Leu 
            100                 105                 110


Pro Leu Met Leu Lys Pro Gly Lys Pro Ala Gly Arg Gly Thr Ile Thr 
        115                 120                 125


Val Ser Ala Gln Glu Leu Lys Asp Asn Arg Val Val Thr Met Glu Val 
    130                 135                 140


Glu Ala Arg Asn Leu Asp Lys Lys Asp Phe Leu Gly Lys Ser Asp Pro 
145                 150                 155                 160


Phe Leu Glu Phe Phe Arg Gln Gly Asp Gly Lys Trp His Leu Val Tyr 
                165                 170                 175


Arg Ser Glu Val Ile Lys Asn Asn Leu Asn Pro Thr Trp Lys Arg Phe 
            180                 185                 190


Ser Val Pro Val Gln His Phe Cys Gly Gly Asn Pro Ser Thr Pro Ile 
        195                 200                 205


Gln Val Gln Cys Ser Asp Tyr Asp Ser Asp Gly Ser His Asp Leu Ile 
    210                 215                 220


Gly Thr Phe His Thr Ser Leu Ala Gln Leu Gln Ala Val Pro Ala Glu 
225                 230                 235                 240


Phe Glu Cys Ile His Pro Glu Lys Gln Gln Lys Lys Lys Ser Tyr Lys 
                245                 250                 255


Asn Ser Gly Thr Ile Arg Val Lys Ile Cys Arg Val Glu Thr Glu Tyr 
            260                 265                 270


Ser Phe Leu Asp Tyr Val Met Gly Gly Cys Gln Ile Asn Phe Thr Val 
        275                 280                 285


Gly Val Asp Phe Thr Gly Ser Asn Gly Asp Pro Ser Ser Pro Asp Ser 
    290                 295                 300


Leu His Tyr Leu Ser Pro Thr Gly Val Asn Glu Tyr Leu Met Ala Leu 
305                 310                 315                 320


Trp Ser Val Gly Ser Val Val Gln Asp Tyr Asp Ser Asp Lys Leu Phe 
                325                 330                 335


Pro Ala Phe Gly Phe Gly Ala Gln Val Pro Pro Asp Trp Gln Val Ser 
            340                 345                 350


His Glu Phe Ala Leu Asn Phe Asn Pro Ser Asn Pro Tyr Cys Ala Gly 
        355                 360                 365


Ile Gln Gly Ile Val Asp Ala Tyr Arg Gln Ala Leu Pro Gln Val Arg 
    370                 375                 380


Leu Tyr Gly Pro Thr Asn Phe Ala Pro Ile Ile Asn His Val Ala Arg 
385                 390                 395                 400


Phe Ala Ala Gln Ala Ala His Gln Gly Thr Ala Ser Gln Tyr Phe Met 
                405                 410                 415


Leu Leu Leu Leu Thr Asp Gly Ala Val Thr Asp Val Glu Ala Thr Arg 
            420                 425                 430


Glu Ala Val Val Arg Ala Ser Asn Leu Pro Met Ser Val Ile Ile Val 
        435                 440                 445


Gly Val Gly Gly Ala Asp Phe Glu Ala Met Glu Gln Leu Asp Ala Asp 
    450                 455                 460


Gly Gly Pro Leu His Thr Arg Ser Gly Gln Ala Ala Ala Arg Asp Ile 
465                 470                 475                 480


Val Gln Phe Val Pro Tyr Arg Arg Phe Gln Asn Ala Pro Arg Glu Ala 
                485                 490                 495


Leu Ala Gln Thr Val Leu Ala Glu Val Pro Thr Gln Leu Val Ser Tyr 
            500                 505                 510


Phe Arg Ala Gln Gly Trp Ala Pro Leu Lys Pro Leu Pro Pro Ser Ala 
        515                 520                 525


Lys Asp Pro Ala Gln Ala Pro Gln Ala 
    530                 535


<210>  1238
<211>  6640
<212>  DNA
<213>  Homo sapiens

<400>  1238
gagcgggccg acggccattt tgtgaagcgg cgaaggaggt ggtggctgcg ttgggctccg     60

ggaagccgtt cgggctgggg ctgtcggccg cggggcggag gcactcgcgc ggggggtaat    120

tcggggtctg ggttctggtg ccgcgcagct ttccccgtct aaaagttggt tttaattggt    180

tgcccacagg attgacttgg cctctacttc ttgttaagga aattcatctc ttgttttatc    240

aggtgtgtgt ggtttcagcg cagcatggct gtggtcatcc gtttgcaagg tctcccaatt    300

gtggcgggga ccatggacat tcgccacttc ttctctggat tgaccattcc tgatgggggc    360

gtgcatattg tagggggtga actgggtgag gctttcatcg tttttgccac tgatgaagat    420

gcaaggcttg gtatgatgcg cacaggtggt acaattaaag ggtcaaaagt aacactattg    480

ttgagtagta agacggaaat gcagaatatg attgaactga gtcgtaggcg ttttgaaact    540

gccaacttag atataccacc agcaaatgcc agtagatcag gaccaccacc tagctcagga    600

atgagtagca gggtaaactt gcccacaaca gtatccaact ttaataatcc atcacccagt    660

gtagttactg ccaccacttc tgttcatgaa agcaacaaaa acatacagac attttccaca    720

gccagcgtag gaacagctcc tccaaatatg ggggcttcct ttgggagccc aacgtttagc    780

tcaactgttc caagcacagc ctctccaatg aacacagtcc cgccgccacc aattcctcca    840

attccagcga tgccatctct gccaccaatg ccatccattc ccccaattcc agttcctcct    900

ccagtaccta cattgcctcc tgtgcctcct gtgcccccga ttcccccagt tccttctgtg    960

ccacccatga ccccactgcc acccatgtcg ggcatgccgc ccttgaatcc gccacctgtg   1020

gcacctctac ctgctggaat gaatggctct ggagcaccta tgaatttgaa caataatctg   1080

aatcctatgt ttcttggtcc gttgaatcct gttaacccta tccagatgaa ctctcagagc   1140

agtgtgaagc cactccccat caaccctgat gatctgtatg tcagtgtgca tggaatgccc   1200

ttttctgcaa tggaaaatga tgtcagagat ttttttcatg ggctccgtgt tgatgcagtg   1260

catttgttga aagatcatgt aggtcgaaat aatgggaatg gattggttaa gtttctctcc   1320

cctcaagata catttgaagc tttgaaacga aacagaatgc tgatgattca acgctatgtg   1380

gaagttagcc ctgccacaga aagacagtgg gtagctgctg gaggccatat cacttttaag   1440

caaaatatgg gaccttctgg acaaactcat ccccctcctc agacacttcc caggtcaaaa   1500

tcgcccagtg ggcagaaaag atcaaggtca agatcaccac atgaggctgg tttttgtgtt   1560

tacttgaaag ggctaccatt tgaagcagaa aacaaacatg tcattgattt ttttaaaaag   1620

ctggatattg tggaagatag tatttatata gcttatggac ccaatgggaa agcaactggc   1680

gaaggctttg tagagttcag aaatgaggct gactataagg ctgctctgtg tcgtcataaa   1740

cagtacatgg gcaatcgctt tattcaagtt catccaatta ctaagaaagg tatgctagaa   1800

aagatagata tgattcgaaa aagactgcag aacttcagct atgaccagag ggaaatgata   1860

ctaaatccag agggggatgt caactctgcc aaagtctgtg cccacataac aaatattcca   1920

ttcagcatta caaagatgga tgttcttcag ttcctagaag gaatcccagt ggatgaaaat   1980

gctgtacatg ttcttgttga taacaatggg caaggtctag gacaggcatt ggttcagttt   2040

aaaaatgaag atgatgcacg taagtctgaa cgcttacacc gtaaaaaact taatgggaga   2100

gaagcttttg ttcatgtagt taccctagaa gatatgagag agattgagaa aaatccccct   2160

gcccaaggaa aaaagggatt aaagatgcct gtgccaggta atcctgcagt tccaggaatg   2220

cccaatgcgg gactgcccgg tgtgggactg cccagtgcag gacttcccgg tgcaggcctg   2280

cccagcacag gactgcctgg ttcagcaata accagtgcag gactgcctgg tgcgggaatg   2340

cccagtgcag gaatacctag tgcaggaggt gaagagcatg ccttcctgac tgtaggatca   2400

aaggaagcca ataatgggcc tccatttaac tttcctggta attttggtgg atcaaatgcc   2460

tttgggccac caatccctcc tccaggatta ggaggcgggg cctttggtga tgctaggcct   2520

ggtatgcctt cagttggaaa cagtggtttg cctggtctag gactggatgt tccgggtttt   2580

ggaggtggac caaacaattt aagtgggcca tcgggatttg gagggggccc tcagaatttt   2640

ggaaatggcc ctggtagctt aggcggtccc ccggggtttg gaagtggccc tcctggtctt   2700

ggaagtgccc ctgggcattt gggtgggcca ccagcttttg ggcctggccc cggccccggc   2760

cccggccctg gcccaatcca tattggtggt ccccctggct ttgcatctag ttctggaaaa   2820

ccaggaccga cagtaattaa agtgcaaaac atgcccttta ctgtgtctat tgatgagatt   2880

ttagatttct tttatggcta tcaagtaatc ccaggctcag tgtgtttaaa atacaatgaa   2940

aaaggtatgc ccacaggtga agccatggtg gcctttgagt ctcgggatga agccacagct   3000

gctgtcattg acttaaatga caggcctata ggttcaagaa aagtaaaact tgtattaggg   3060

tagccattca catcattttt tatagggtag atcttcatat tgctgtgatt aatgcatcca   3120

gattgttttc ctagtatttc caggttagaa cctgtggatt gtttcaattg catatagctt   3180

ggtttccata acatagagca ttggttgact gtttacagaa gactcactca ccaggataaa   3240

cattgctgta tgttacagta aagctatctg gagagaacac ataaatgatt ttggcatacc   3300

attagagaaa ccatttgtaa aactcaaatg accacataaa gcttatcaag gagtctagat   3360

tggttttgtt ttataccata tgggatgaag aaaatagaaa tgtcagtaga actcattgag   3420

ggtgctcttg ccagctgctg aaaatagaag ttggctactc tcagaatttg gtttaaagct   3480

ggacagattt gctttgttat agggtaaagc tttgtctaaa gtcctcattt tcttttaaaa   3540

ttgaataaaa tttctgtata cagattcatt gtatgtacct ttattgcttc ttaagggtcc   3600

ttgctgtata gacagtcctg cttcagaagt tgctgctttg tttgtctaat tgactcattt   3660

gtaaatgagc agaactgttt tgttggtttt tttccctaaa tataaaagtc cacacttcgt   3720

ttgtgctata acctcaaact ttgatttcta atgtcacact taaaactgtg tggaataaga   3780

cttttgccat aaaaataaac tatggagtcc tttatctacc agagcctttt tggtttgacc   3840

gccacgattt aggttagtca gtttaaaaat tgttcatgtt gtttggatgg tatcgaaaac   3900

cagaaaccac ttttaataat gtgtttaaga tacttgattt gaagtccttt tcatatggac   3960

taattgtagt atcaatttcc tcctgtcccg attatgtgaa attttggcct ttaaacaaag   4020

aggggcccat tcataagaaa gtgttatatc taggttttta aaactgaagt tgaaattatc   4080

tttgttagca gtagtagtat agaataaaag atccgtatgc tggttcgtag attgatacgt   4140

gttagtcctg ttatttggag gctttttggc atagttgttc gatcaggagc ctgtttacta   4200

aaagtcttca tacagagtac aagtgcagcc gccagaggag aaaattgaga ttcttgaccc   4260

tttcatactc ttttctttgg tattcaggac actaaggcag gaggaccaca tgagttctgg   4320

ttggtaagtg tccttgtcat gaaaacactt gccttacaag gctctaatta tgatttccct   4380

agtcagtgct ctgaagatgt gtcacattat attataaaca atacggaagg ggagataggt   4440

gagatgatat gaaaaacaaa ttttctcact gtcataaaag gctctaatta tggttacttt   4500

ccttgtgatg aaaaacttgg ccttacaggg ctctagttat ggttactttc cctagtcaat   4560

gctctgaaaa tgtgtcacat tataaacaat acagaaggag agatagatga gagatcatga   4620

aaaccaaatt ttatctttta catggcccct ttgtcttcgt ttgaaacatc cccaacattt   4680

cctacaaatc agcgtagtta caaaggggtc agtcttttaa aataagtatt tcctattaaa   4740

ctatatatat atacagtgcc tttttggtgt tgtgagtcag tggaacactg aaatacagcg   4800

gttgtgtaat ttaagagtgg caacagtttc atttgataag atttgaaaag gctttttatc   4860

actacaatct tagaggattg acagtacagg atttttgttt aagagaagga ttgtttagac   4920

tcaagaggtg actatgttgt gggtcttttg ataattcatg aatacagatt tgctttgacc   4980

gatcactaga tactgcctcc tcaatttcaa aagcaatata acgtttgtat atgctgttta   5040

atttaagtta atgttaagta atcatttctc attccaaaga caatgcaaaa aacttcagca   5100

ctgcttgaga gttgtatttc agccacagat attttctcca ttggaaagct attttcattt   5160

tagaaaaatg ggttgtttga agatgaaagt cttttatctt ttttcacaat ttattttggt   5220

tatatgttcg tacattctta ttaaatattt catacacttt attgcaacta ctttgttatt   5280

tctacatctt agataaatgc tgaaaaggaa aacgatttca ttgttcatct aattaaataa   5340

attaaaagag cggtttgtgt agaaattgga gagaactatg ttttatatga atcacaacag   5400

tgctcgttgt ggactgtaat taaatgcttt gccctctgga acttgatttt tgtgtatctg   5460

agatttatta acagtgctaa ctgctaagga tactgtttat cttgttctgg gcattggagt   5520

ttcagttttt aaaaaattct tgaaaatgta ttctgtgaaa ctactcatac ctctcttcct   5580

gcgaattttc tcctaagaac taggtttggg gtagaaatga attgacatta ttttctcatt   5640

tgctttgtat ggtatgaagg atttgtaaag ctttgctcaa agttgtgtgc atttgtaaac   5700

actatcatga tattttcaat tttatgtgta aattttattg tctgtttttg gtgactctga   5760

cattaatgga agagaatatt ttccattaga tttaattttt tttcctctcc cttctgattt   5820

tttttttatt ggtgttcatt tttcttttga tttaaaggat tagagaaatc tacaaatgta   5880

tgtcataaat aagcaaattt gtaaactttt ctgaacttta gtgaaacatt tagttcacaa   5940

gcataatttg gaggtgtgtt ctgtgtttac acagtagttt ggatgtacaa ttattattag   6000

tggcttttta aaaaatgaaa cagtgttaag tgaaatgtag ttcctagctt tgtactccaa   6060

gttgtcaaag catcaacaat gaaaattcga ttaggaaact ttatttaaaa tttcaggtag   6120

taatattcag tgtagttaag gccagtctta acccactgga tgaaaatcta ggactgtatg   6180

gaagtaagca aacattacat ttttaggtgg aaatagtcag ccttgcataa aaacaaggat   6240

gcgtgaaagc cttaaattcc agctcccttt tactggagtc tgtggttgtg tacaggtatg   6300

ggccaagtgt aaaatctcat caattttaag aacactcggg aaatgagtaa agaaaatgta   6360

aaattgctgc tagtcaaatc ttttggaaag aatttctgga agtggtcact ttaaaaatta   6420

ttttccaccc ttgcaaaatt gccacattta aattgtttta ctggcagttc tatagtagtc   6480

cagactttag aaaccaaaca caacaaaatg gcttgttgcc aatatggcca caacattgcc   6540

agcaaatact gccttggcat cactcagcag aggtttttgt ttataaagat gaagtcttga   6600

atactgttca ataaacttgt caaaaaataa aaaaaaaaaa                         6640


<210>  1239
<211>  932
<212>  PRT
<213>  Homo sapiens

<400>  1239

Met Ala Val Val Ile Arg Leu Gln Gly Leu Pro Ile Val Ala Gly Thr 
1               5                   10                  15


Met Asp Ile Arg His Phe Phe Ser Gly Leu Thr Ile Pro Asp Gly Gly 
            20                  25                  30


Val His Ile Val Gly Gly Glu Leu Gly Glu Ala Phe Ile Val Phe Ala 
        35                  40                  45


Thr Asp Glu Asp Ala Arg Leu Gly Met Met Arg Thr Gly Gly Thr Ile 
    50                  55                  60


Lys Gly Ser Lys Val Thr Leu Leu Leu Ser Ser Lys Thr Glu Met Gln 
65                  70                  75                  80


Asn Met Ile Glu Leu Ser Arg Arg Arg Phe Glu Thr Ala Asn Leu Asp 
                85                  90                  95


Ile Pro Pro Ala Asn Ala Ser Arg Ser Gly Pro Pro Pro Ser Ser Gly 
            100                 105                 110


Met Ser Ser Arg Val Asn Leu Pro Thr Thr Val Ser Asn Phe Asn Asn 
        115                 120                 125


Pro Ser Pro Ser Val Val Thr Ala Thr Thr Ser Val His Glu Ser Asn 
    130                 135                 140


Lys Asn Ile Gln Thr Phe Ser Thr Ala Ser Val Gly Thr Ala Pro Pro 
145                 150                 155                 160


Asn Met Gly Ala Ser Phe Gly Ser Pro Thr Phe Ser Ser Thr Val Pro 
                165                 170                 175


Ser Thr Ala Ser Pro Met Asn Thr Val Pro Pro Pro Pro Ile Pro Pro 
            180                 185                 190


Ile Pro Ala Met Pro Ser Leu Pro Pro Met Pro Ser Ile Pro Pro Ile 
        195                 200                 205


Pro Val Pro Pro Pro Val Pro Thr Leu Pro Pro Val Pro Pro Val Pro 
    210                 215                 220


Pro Ile Pro Pro Val Pro Ser Val Pro Pro Met Thr Pro Leu Pro Pro 
225                 230                 235                 240


Met Ser Gly Met Pro Pro Leu Asn Pro Pro Pro Val Ala Pro Leu Pro 
                245                 250                 255


Ala Gly Met Asn Gly Ser Gly Ala Pro Met Asn Leu Asn Asn Asn Leu 
            260                 265                 270


Asn Pro Met Phe Leu Gly Pro Leu Asn Pro Val Asn Pro Ile Gln Met 
        275                 280                 285


Asn Ser Gln Ser Ser Val Lys Pro Leu Pro Ile Asn Pro Asp Asp Leu 
    290                 295                 300


Tyr Val Ser Val His Gly Met Pro Phe Ser Ala Met Glu Asn Asp Val 
305                 310                 315                 320


Arg Asp Phe Phe His Gly Leu Arg Val Asp Ala Val His Leu Leu Lys 
                325                 330                 335


Asp His Val Gly Arg Asn Asn Gly Asn Gly Leu Val Lys Phe Leu Ser 
            340                 345                 350


Pro Gln Asp Thr Phe Glu Ala Leu Lys Arg Asn Arg Met Leu Met Ile 
        355                 360                 365


Gln Arg Tyr Val Glu Val Ser Pro Ala Thr Glu Arg Gln Trp Val Ala 
    370                 375                 380


Ala Gly Gly His Ile Thr Phe Lys Gln Asn Met Gly Pro Ser Gly Gln 
385                 390                 395                 400


Thr His Pro Pro Pro Gln Thr Leu Pro Arg Ser Lys Ser Pro Ser Gly 
                405                 410                 415


Gln Lys Arg Ser Arg Ser Arg Ser Pro His Glu Ala Gly Phe Cys Val 
            420                 425                 430


Tyr Leu Lys Gly Leu Pro Phe Glu Ala Glu Asn Lys His Val Ile Asp 
        435                 440                 445


Phe Phe Lys Lys Leu Asp Ile Val Glu Asp Ser Ile Tyr Ile Ala Tyr 
    450                 455                 460


Gly Pro Asn Gly Lys Ala Thr Gly Glu Gly Phe Val Glu Phe Arg Asn 
465                 470                 475                 480


Glu Ala Asp Tyr Lys Ala Ala Leu Cys Arg His Lys Gln Tyr Met Gly 
                485                 490                 495


Asn Arg Phe Ile Gln Val His Pro Ile Thr Lys Lys Gly Met Leu Glu 
            500                 505                 510


Lys Ile Asp Met Ile Arg Lys Arg Leu Gln Asn Phe Ser Tyr Asp Gln 
        515                 520                 525


Arg Glu Met Ile Leu Asn Pro Glu Gly Asp Val Asn Ser Ala Lys Val 
    530                 535                 540


Cys Ala His Ile Thr Asn Ile Pro Phe Ser Ile Thr Lys Met Asp Val 
545                 550                 555                 560


Leu Gln Phe Leu Glu Gly Ile Pro Val Asp Glu Asn Ala Val His Val 
                565                 570                 575


Leu Val Asp Asn Asn Gly Gln Gly Leu Gly Gln Ala Leu Val Gln Phe 
            580                 585                 590


Lys Asn Glu Asp Asp Ala Arg Lys Ser Glu Arg Leu His Arg Lys Lys 
        595                 600                 605


Leu Asn Gly Arg Glu Ala Phe Val His Val Val Thr Leu Glu Asp Met 
    610                 615                 620


Arg Glu Ile Glu Lys Asn Pro Pro Ala Gln Gly Lys Lys Gly Leu Lys 
625                 630                 635                 640


Met Pro Val Pro Gly Asn Pro Ala Val Pro Gly Met Pro Asn Ala Gly 
                645                 650                 655


Leu Pro Gly Val Gly Leu Pro Ser Ala Gly Leu Pro Gly Ala Gly Leu 
            660                 665                 670


Pro Ser Thr Gly Leu Pro Gly Ser Ala Ile Thr Ser Ala Gly Leu Pro 
        675                 680                 685


Gly Ala Gly Met Pro Ser Ala Gly Ile Pro Ser Ala Gly Gly Glu Glu 
    690                 695                 700


His Ala Phe Leu Thr Val Gly Ser Lys Glu Ala Asn Asn Gly Pro Pro 
705                 710                 715                 720


Phe Asn Phe Pro Gly Asn Phe Gly Gly Ser Asn Ala Phe Gly Pro Pro 
                725                 730                 735


Ile Pro Pro Pro Gly Leu Gly Gly Gly Ala Phe Gly Asp Ala Arg Pro 
            740                 745                 750


Gly Met Pro Ser Val Gly Asn Ser Gly Leu Pro Gly Leu Gly Leu Asp 
        755                 760                 765


Val Pro Gly Phe Gly Gly Gly Pro Asn Asn Leu Ser Gly Pro Ser Gly 
    770                 775                 780


Phe Gly Gly Gly Pro Gln Asn Phe Gly Asn Gly Pro Gly Ser Leu Gly 
785                 790                 795                 800


Gly Pro Pro Gly Phe Gly Ser Gly Pro Pro Gly Leu Gly Ser Ala Pro 
                805                 810                 815


Gly His Leu Gly Gly Pro Pro Ala Phe Gly Pro Gly Pro Gly Pro Gly 
            820                 825                 830


Pro Gly Pro Gly Pro Ile His Ile Gly Gly Pro Pro Gly Phe Ala Ser 
        835                 840                 845


Ser Ser Gly Lys Pro Gly Pro Thr Val Ile Lys Val Gln Asn Met Pro 
    850                 855                 860


Phe Thr Val Ser Ile Asp Glu Ile Leu Asp Phe Phe Tyr Gly Tyr Gln 
865                 870                 875                 880


Val Ile Pro Gly Ser Val Cys Leu Lys Tyr Asn Glu Lys Gly Met Pro 
                885                 890                 895


Thr Gly Glu Ala Met Val Ala Phe Glu Ser Arg Asp Glu Ala Thr Ala 
            900                 905                 910


Ala Val Ile Asp Leu Asn Asp Arg Pro Ile Gly Ser Arg Lys Val Lys 
        915                 920                 925


Leu Val Leu Gly 
    930


<210>  1240
<211>  6608
<212>  DNA
<213>  Homo sapiens

<400>  1240
gagcgggccg acggccattt tgtgaagcgg cgaaggaggt ggtggctgcg ttgggctccg     60

ggaagccgtt cgggctgggg ctgtcggccg cggggcggag gcactcgcgc ggggggtaat    120

tcggggtctg ggttctggtg ccgcgcagct ttccccggat tgacttggcc tctacttctt    180

gttaaggaaa ttcatctctt gttttatcag gtgtgtgtgg tttcagcgca gcatggctgt    240

ggtcatccgt ttgcaaggtc tcccaattgt ggcggggacc atggacattc gccacttctt    300

ctctggattg accattcctg atgggggcgt gcatattgta gggggtgaac tgggtgaggc    360

tttcatcgtt tttgccactg atgaagatgc aaggcttggt atgatgcgca caggtggtac    420

aattaaaggg tcaaaagtaa cactattgtt gagtagtaag acggaaatgc agaatatgat    480

tgaactgagt cgtaggcgtt ttgaaactgc caacttagat ataccaccag caaatgccag    540

tagatcagga ccaccaccta gctcaggaat gagtagcagg gtaaacttgc ccacaacagt    600

atccaacttt aataatccat cacccagtgt agttactgcc accacttctg ttcatgaaag    660

caacaaaaac atacagacat tttccacagc cagcgtagga acagctcctc caaatatggg    720

ggcttccttt gggagcccaa cgtttagctc aactgttcca agcacagcct ctccaatgaa    780

cacagtcccg ccgccaccaa ttcctccaat tccagcgatg ccatctctgc caccaatgcc    840

atccattccc ccaattccag ttcctcctcc agtacctaca ttgcctcctg tgcctcctgt    900

gcccccgatt cccccagttc cttctgtgcc acccatgacc ccactgccac ccatgtcggg    960

catgccgccc ttgaatccgc cacctgtggc acctctacct gctggaatga atggctctgg   1020

agcacctatg aatttgaaca ataatctgaa tcctatgttt cttggtccgt tgaatcctgt   1080

taaccctatc cagatgaact ctcagagcag tgtgaagcca ctccccatca accctgatga   1140

tctgtatgtc agtgtgcatg gaatgccctt ttctgcaatg gaaaatgatg tcagagattt   1200

ttttcatggg ctccgtgttg atgcagtgca tttgttgaaa gatcatgtag gtcgaaataa   1260

tgggaatgga ttggttaagt ttctctcccc tcaagataca tttgaagctt tgaaacgaaa   1320

cagaatgctg atgattcaac gctatgtgga agttagccct gccacagaaa gacagtgggt   1380

agctgctgga ggccatatca cttttaagca aaatatggga ccttctggac aaactcatcc   1440

ccctcctcag acacttccca ggtcaaaatc gcccagtggg cagaaaagat caaggtcaag   1500

atcaccacat gaggctggtt tttgtgttta cttgaaaggg ctaccatttg aagcagaaaa   1560

caaacatgtc attgattttt ttaaaaagct ggatattgtg gaagatagta tttatatagc   1620

ttatggaccc aatgggaaag caactggcga aggctttgta gagttcagaa atgaggctga   1680

ctataaggct gctctgtgtc gtcataaaca gtacatgggc aatcgcttta ttcaagttca   1740

tccaattact aagaaaggta tgctagaaaa gatagatatg attcgaaaaa gactgcagaa   1800

cttcagctat gaccagaggg aaatgatact aaatccagag ggggatgtca actctgccaa   1860

agtctgtgcc cacataacaa atattccatt cagcattaca aagatggatg ttcttcagtt   1920

cctagaagga atcccagtgg atgaaaatgc tgtacatgtt cttgttgata acaatgggca   1980

aggtctagga caggcattgg ttcagtttaa aaatgaagat gatgcacgta agtctgaacg   2040

cttacaccgt aaaaaactta atgggagaga agcttttgtt catgtagtta ccctagaaga   2100

tatgagagag attgagaaaa atccccctgc ccaaggaaaa aagggattaa agatgcctgt   2160

gccaggtaat cctgcagttc caggaatgcc caatgcggga ctgcccggtg tgggactgcc   2220

cagtgcagga cttcccggtg caggcctgcc cagcacagga ctgcctggtt cagcaataac   2280

cagtgcagga ctgcctggtg cgggaatgcc cagtgcagga atacctagtg caggaggtga   2340

agagcatgcc ttcctgactg taggatcaaa ggaagccaat aatgggcctc catttaactt   2400

tcctggtaat tttggtggat caaatgcctt tgggccacca atccctcctc caggattagg   2460

aggcggggcc tttggtgatg ctaggcctgg tatgccttca gttggaaaca gtggtttgcc   2520

tggtctagga ctggatgttc cgggttttgg aggtggacca aacaatttaa gtgggccatc   2580

gggatttgga gggggccctc agaattttgg aaatggccct ggtagcttag gcggtccccc   2640

ggggtttgga agtggccctc ctggtcttgg aagtgcccct gggcatttgg gtgggccacc   2700

agcttttggg cctggccccg gccccggccc cggccctggc ccaatccata ttggtggtcc   2760

ccctggcttt gcatctagtt ctggaaaacc aggaccgaca gtaattaaag tgcaaaacat   2820

gccctttact gtgtctattg atgagatttt agatttcttt tatggctatc aagtaatccc   2880

aggctcagtg tgtttaaaat acaatgaaaa aggtatgccc acaggtgaag ccatggtggc   2940

ctttgagtct cgggatgaag ccacagctgc tgtcattgac ttaaatgaca ggcctatagg   3000

ttcaagaaaa gtaaaacttg tattagggta gccattcaca tcatttttta tagggtagat   3060

cttcatattg ctgtgattaa tgcatccaga ttgttttcct agtatttcca ggttagaacc   3120

tgtggattgt ttcaattgca tatagcttgg tttccataac atagagcatt ggttgactgt   3180

ttacagaaga ctcactcacc aggataaaca ttgctgtatg ttacagtaaa gctatctgga   3240

gagaacacat aaatgatttt ggcataccat tagagaaacc atttgtaaaa ctcaaatgac   3300

cacataaagc ttatcaagga gtctagattg gttttgtttt ataccatatg ggatgaagaa   3360

aatagaaatg tcagtagaac tcattgaggg tgctcttgcc agctgctgaa aatagaagtt   3420

ggctactctc agaatttggt ttaaagctgg acagatttgc tttgttatag ggtaaagctt   3480

tgtctaaagt cctcattttc ttttaaaatt gaataaaatt tctgtataca gattcattgt   3540

atgtaccttt attgcttctt aagggtcctt gctgtataga cagtcctgct tcagaagttg   3600

ctgctttgtt tgtctaattg actcatttgt aaatgagcag aactgttttg ttggtttttt   3660

tccctaaata taaaagtcca cacttcgttt gtgctataac ctcaaacttt gatttctaat   3720

gtcacactta aaactgtgtg gaataagact tttgccataa aaataaacta tggagtcctt   3780

tatctaccag agcctttttg gtttgaccgc cacgatttag gttagtcagt ttaaaaattg   3840

ttcatgttgt ttggatggta tcgaaaacca gaaaccactt ttaataatgt gtttaagata   3900

cttgatttga agtccttttc atatggacta attgtagtat caatttcctc ctgtcccgat   3960

tatgtgaaat tttggccttt aaacaaagag gggcccattc ataagaaagt gttatatcta   4020

ggtttttaaa actgaagttg aaattatctt tgttagcagt agtagtatag aataaaagat   4080

ccgtatgctg gttcgtagat tgatacgtgt tagtcctgtt atttggaggc tttttggcat   4140

agttgttcga tcaggagcct gtttactaaa agtcttcata cagagtacaa gtgcagccgc   4200

cagaggagaa aattgagatt cttgaccctt tcatactctt ttctttggta ttcaggacac   4260

taaggcagga ggaccacatg agttctggtt ggtaagtgtc cttgtcatga aaacacttgc   4320

cttacaaggc tctaattatg atttccctag tcagtgctct gaagatgtgt cacattatat   4380

tataaacaat acggaagggg agataggtga gatgatatga aaaacaaatt ttctcactgt   4440

cataaaaggc tctaattatg gttactttcc ttgtgatgaa aaacttggcc ttacagggct   4500

ctagttatgg ttactttccc tagtcaatgc tctgaaaatg tgtcacatta taaacaatac   4560

agaaggagag atagatgaga gatcatgaaa accaaatttt atcttttaca tggccccttt   4620

gtcttcgttt gaaacatccc caacatttcc tacaaatcag cgtagttaca aaggggtcag   4680

tcttttaaaa taagtatttc ctattaaact atatatatat acagtgcctt tttggtgttg   4740

tgagtcagtg gaacactgaa atacagcggt tgtgtaattt aagagtggca acagtttcat   4800

ttgataagat ttgaaaaggc tttttatcac tacaatctta gaggattgac agtacaggat   4860

ttttgtttaa gagaaggatt gtttagactc aagaggtgac tatgttgtgg gtcttttgat   4920

aattcatgaa tacagatttg ctttgaccga tcactagata ctgcctcctc aatttcaaaa   4980

gcaatataac gtttgtatat gctgtttaat ttaagttaat gttaagtaat catttctcat   5040

tccaaagaca atgcaaaaaa cttcagcact gcttgagagt tgtatttcag ccacagatat   5100

tttctccatt ggaaagctat tttcatttta gaaaaatggg ttgtttgaag atgaaagtct   5160

tttatctttt ttcacaattt attttggtta tatgttcgta cattcttatt aaatatttca   5220

tacactttat tgcaactact ttgttatttc tacatcttag ataaatgctg aaaaggaaaa   5280

cgatttcatt gttcatctaa ttaaataaat taaaagagcg gtttgtgtag aaattggaga   5340

gaactatgtt ttatatgaat cacaacagtg ctcgttgtgg actgtaatta aatgctttgc   5400

cctctggaac ttgatttttg tgtatctgag atttattaac agtgctaact gctaaggata   5460

ctgtttatct tgttctgggc attggagttt cagtttttaa aaaattcttg aaaatgtatt   5520

ctgtgaaact actcatacct ctcttcctgc gaattttctc ctaagaacta ggtttggggt   5580

agaaatgaat tgacattatt ttctcatttg ctttgtatgg tatgaaggat ttgtaaagct   5640

ttgctcaaag ttgtgtgcat ttgtaaacac tatcatgata ttttcaattt tatgtgtaaa   5700

ttttattgtc tgtttttggt gactctgaca ttaatggaag agaatatttt ccattagatt   5760

taattttttt tcctctccct tctgattttt tttttattgg tgttcatttt tcttttgatt   5820

taaaggatta gagaaatcta caaatgtatg tcataaataa gcaaatttgt aaacttttct   5880

gaactttagt gaaacattta gttcacaagc ataatttgga ggtgtgttct gtgtttacac   5940

agtagtttgg atgtacaatt attattagtg gctttttaaa aaatgaaaca gtgttaagtg   6000

aaatgtagtt cctagctttg tactccaagt tgtcaaagca tcaacaatga aaattcgatt   6060

aggaaacttt atttaaaatt tcaggtagta atattcagtg tagttaaggc cagtcttaac   6120

ccactggatg aaaatctagg actgtatgga agtaagcaaa cattacattt ttaggtggaa   6180

atagtcagcc ttgcataaaa acaaggatgc gtgaaagcct taaattccag ctccctttta   6240

ctggagtctg tggttgtgta caggtatggg ccaagtgtaa aatctcatca attttaagaa   6300

cactcgggaa atgagtaaag aaaatgtaaa attgctgcta gtcaaatctt ttggaaagaa   6360

tttctggaag tggtcacttt aaaaattatt ttccaccctt gcaaaattgc cacatttaaa   6420

ttgttttact ggcagttcta tagtagtcca gactttagaa accaaacaca acaaaatggc   6480

ttgttgccaa tatggccaca acattgccag caaatactgc cttggcatca ctcagcagag   6540

gtttttgttt ataaagatga agtcttgaat actgttcaat aaacttgtca aaaaataaaa   6600

aaaaaaaa                                                            6608


<210>  1241
<211>  932
<212>  PRT
<213>  Homo sapiens

<400>  1241

Met Ala Val Val Ile Arg Leu Gln Gly Leu Pro Ile Val Ala Gly Thr 
1               5                   10                  15


Met Asp Ile Arg His Phe Phe Ser Gly Leu Thr Ile Pro Asp Gly Gly 
            20                  25                  30


Val His Ile Val Gly Gly Glu Leu Gly Glu Ala Phe Ile Val Phe Ala 
        35                  40                  45


Thr Asp Glu Asp Ala Arg Leu Gly Met Met Arg Thr Gly Gly Thr Ile 
    50                  55                  60


Lys Gly Ser Lys Val Thr Leu Leu Leu Ser Ser Lys Thr Glu Met Gln 
65                  70                  75                  80


Asn Met Ile Glu Leu Ser Arg Arg Arg Phe Glu Thr Ala Asn Leu Asp 
                85                  90                  95


Ile Pro Pro Ala Asn Ala Ser Arg Ser Gly Pro Pro Pro Ser Ser Gly 
            100                 105                 110


Met Ser Ser Arg Val Asn Leu Pro Thr Thr Val Ser Asn Phe Asn Asn 
        115                 120                 125


Pro Ser Pro Ser Val Val Thr Ala Thr Thr Ser Val His Glu Ser Asn 
    130                 135                 140


Lys Asn Ile Gln Thr Phe Ser Thr Ala Ser Val Gly Thr Ala Pro Pro 
145                 150                 155                 160


Asn Met Gly Ala Ser Phe Gly Ser Pro Thr Phe Ser Ser Thr Val Pro 
                165                 170                 175


Ser Thr Ala Ser Pro Met Asn Thr Val Pro Pro Pro Pro Ile Pro Pro 
            180                 185                 190


Ile Pro Ala Met Pro Ser Leu Pro Pro Met Pro Ser Ile Pro Pro Ile 
        195                 200                 205


Pro Val Pro Pro Pro Val Pro Thr Leu Pro Pro Val Pro Pro Val Pro 
    210                 215                 220


Pro Ile Pro Pro Val Pro Ser Val Pro Pro Met Thr Pro Leu Pro Pro 
225                 230                 235                 240


Met Ser Gly Met Pro Pro Leu Asn Pro Pro Pro Val Ala Pro Leu Pro 
                245                 250                 255


Ala Gly Met Asn Gly Ser Gly Ala Pro Met Asn Leu Asn Asn Asn Leu 
            260                 265                 270


Asn Pro Met Phe Leu Gly Pro Leu Asn Pro Val Asn Pro Ile Gln Met 
        275                 280                 285


Asn Ser Gln Ser Ser Val Lys Pro Leu Pro Ile Asn Pro Asp Asp Leu 
    290                 295                 300


Tyr Val Ser Val His Gly Met Pro Phe Ser Ala Met Glu Asn Asp Val 
305                 310                 315                 320


Arg Asp Phe Phe His Gly Leu Arg Val Asp Ala Val His Leu Leu Lys 
                325                 330                 335


Asp His Val Gly Arg Asn Asn Gly Asn Gly Leu Val Lys Phe Leu Ser 
            340                 345                 350


Pro Gln Asp Thr Phe Glu Ala Leu Lys Arg Asn Arg Met Leu Met Ile 
        355                 360                 365


Gln Arg Tyr Val Glu Val Ser Pro Ala Thr Glu Arg Gln Trp Val Ala 
    370                 375                 380


Ala Gly Gly His Ile Thr Phe Lys Gln Asn Met Gly Pro Ser Gly Gln 
385                 390                 395                 400


Thr His Pro Pro Pro Gln Thr Leu Pro Arg Ser Lys Ser Pro Ser Gly 
                405                 410                 415


Gln Lys Arg Ser Arg Ser Arg Ser Pro His Glu Ala Gly Phe Cys Val 
            420                 425                 430


Tyr Leu Lys Gly Leu Pro Phe Glu Ala Glu Asn Lys His Val Ile Asp 
        435                 440                 445


Phe Phe Lys Lys Leu Asp Ile Val Glu Asp Ser Ile Tyr Ile Ala Tyr 
    450                 455                 460


Gly Pro Asn Gly Lys Ala Thr Gly Glu Gly Phe Val Glu Phe Arg Asn 
465                 470                 475                 480


Glu Ala Asp Tyr Lys Ala Ala Leu Cys Arg His Lys Gln Tyr Met Gly 
                485                 490                 495


Asn Arg Phe Ile Gln Val His Pro Ile Thr Lys Lys Gly Met Leu Glu 
            500                 505                 510


Lys Ile Asp Met Ile Arg Lys Arg Leu Gln Asn Phe Ser Tyr Asp Gln 
        515                 520                 525


Arg Glu Met Ile Leu Asn Pro Glu Gly Asp Val Asn Ser Ala Lys Val 
    530                 535                 540


Cys Ala His Ile Thr Asn Ile Pro Phe Ser Ile Thr Lys Met Asp Val 
545                 550                 555                 560


Leu Gln Phe Leu Glu Gly Ile Pro Val Asp Glu Asn Ala Val His Val 
                565                 570                 575


Leu Val Asp Asn Asn Gly Gln Gly Leu Gly Gln Ala Leu Val Gln Phe 
            580                 585                 590


Lys Asn Glu Asp Asp Ala Arg Lys Ser Glu Arg Leu His Arg Lys Lys 
        595                 600                 605


Leu Asn Gly Arg Glu Ala Phe Val His Val Val Thr Leu Glu Asp Met 
    610                 615                 620


Arg Glu Ile Glu Lys Asn Pro Pro Ala Gln Gly Lys Lys Gly Leu Lys 
625                 630                 635                 640


Met Pro Val Pro Gly Asn Pro Ala Val Pro Gly Met Pro Asn Ala Gly 
                645                 650                 655


Leu Pro Gly Val Gly Leu Pro Ser Ala Gly Leu Pro Gly Ala Gly Leu 
            660                 665                 670


Pro Ser Thr Gly Leu Pro Gly Ser Ala Ile Thr Ser Ala Gly Leu Pro 
        675                 680                 685


Gly Ala Gly Met Pro Ser Ala Gly Ile Pro Ser Ala Gly Gly Glu Glu 
    690                 695                 700


His Ala Phe Leu Thr Val Gly Ser Lys Glu Ala Asn Asn Gly Pro Pro 
705                 710                 715                 720


Phe Asn Phe Pro Gly Asn Phe Gly Gly Ser Asn Ala Phe Gly Pro Pro 
                725                 730                 735


Ile Pro Pro Pro Gly Leu Gly Gly Gly Ala Phe Gly Asp Ala Arg Pro 
            740                 745                 750


Gly Met Pro Ser Val Gly Asn Ser Gly Leu Pro Gly Leu Gly Leu Asp 
        755                 760                 765


Val Pro Gly Phe Gly Gly Gly Pro Asn Asn Leu Ser Gly Pro Ser Gly 
    770                 775                 780


Phe Gly Gly Gly Pro Gln Asn Phe Gly Asn Gly Pro Gly Ser Leu Gly 
785                 790                 795                 800


Gly Pro Pro Gly Phe Gly Ser Gly Pro Pro Gly Leu Gly Ser Ala Pro 
                805                 810                 815


Gly His Leu Gly Gly Pro Pro Ala Phe Gly Pro Gly Pro Gly Pro Gly 
            820                 825                 830


Pro Gly Pro Gly Pro Ile His Ile Gly Gly Pro Pro Gly Phe Ala Ser 
        835                 840                 845


Ser Ser Gly Lys Pro Gly Pro Thr Val Ile Lys Val Gln Asn Met Pro 
    850                 855                 860


Phe Thr Val Ser Ile Asp Glu Ile Leu Asp Phe Phe Tyr Gly Tyr Gln 
865                 870                 875                 880


Val Ile Pro Gly Ser Val Cys Leu Lys Tyr Asn Glu Lys Gly Met Pro 
                885                 890                 895


Thr Gly Glu Ala Met Val Ala Phe Glu Ser Arg Asp Glu Ala Thr Ala 
            900                 905                 910


Ala Val Ile Asp Leu Asn Asp Arg Pro Ile Gly Ser Arg Lys Val Lys 
        915                 920                 925


Leu Val Leu Gly 
    930


<210>  1242
<211>  2371
<212>  DNA
<213>  Homo sapiens

<400>  1242
acttccggga gcctggggcc caggactgca gcggcttcgg aaggtgggct ctgccagcgg     60

gaccatgctg ctccgagccg cttggaggcg ggcggcagtg gcggtgacag cggctccagg    120

gccgaagccc gcggcgccca ctcgggggct gcgcctgcgc gttggagacc gtgctcctca    180

gtctgcggtt cccgcagata cagccgctgc cccggaggtg gggccagtgc tgcgacctct    240

ctatatggat gtgcaagcta caactcctct ggacccccgg gtgcttgatg ccatgctccc    300

ttacctaatc aactactatg ggaacccaca ctcccggaca catgcttatg gctgggagag    360

tgaggcagcc atggaacgtg ctcgtcagca agtagcatct ctgattggag ctgatcctcg    420

tgagatcatt tttactagtg gtgctactga atccaacaac atagcaatta agggggtggc    480

ccgattctac aggtcacgga aaaagcactt gatcaccacc cagacagaac acaaatgtgt    540

cttggactcc tgccgttcac tggaagctga gggctttcag gtcacctacc tcccagtgca    600

gaagagtggg atcattgacc taaaggaact agaggctgct atccagccag atactagcct    660

ggtgtcagtc atgactgtga acaatgagat tggagtgaag cagcctattg cagaaatagg    720

gcggatttgc agttccagaa aggtatattt ccatactgat gcagcccagg ctgttggaaa    780

aatcccactt gatgtcaatg acatgaaaat tgatctcatg agcattagtg gtcacaaaat    840

ctacggtccc aaaggggttg gtgccatcta catccgtcgc cggccccgtg tgcgtgtgga    900

ggccctgcag agtggagggg ggcaggagcg gggtatgcgg tctgggacag tgcccacacc    960

cttagtggtg gggctggggg ctgcgtgtga ggtggcacag caagagatgg agtatgacca   1020

caagcgaatc tcaaagttgt cagagcggct gatacagaat ataatgaaga gccttccaga   1080

tgtggtgatg aatggggacc ctaagcacca ttatcccggc tgtatcaacc tctcctttgc   1140

atatgtggaa ggggaaagtc tgctgatggc actgaaggac gttgccttat cctcagggag   1200

tgcctgcacc tctgcatccc tggagccctc ttatgtgctt agagcaattg gcactgatga   1260

ggatttagcg cactcttcta tcaggtttgg aattggccgc ttcactacag aggaggaagt   1320

ggactacaca gtggagaaat gcattcagca tgtgaagcgt cttcgagaaa tgagccctct   1380

ctgggagatg gttcaggatg gcattgacct caagagcatc aagtggaccc aacactagaa   1440

gaatagggcc ctgactttgt gctggtctgg cccctcctgc ctcaccaacc cgtgcacaac   1500

cagacacctt gttacaccta gtggatgctc tagattggta tagaccagtt gacttcagca   1560

tcagtccacc tctatgacag aaacacaaga aaactgtctt tccctagctt cagttccttg   1620

ggtgtggagc actccccatt tcttctcggg tcttaaagtg tgtggacatt ttcatcccga   1680

agccatagag acatttgctg tcatattgct gctgggcaca tctgtgctct tggtgaggag   1740

agcaagagga accagaagaa gtctctttgg tcagggacca tgatgctcta catggacatt   1800

tgagtcttcg tcttctgctg ctgctcggct ggaccagctt ctttaacagc aagcataatc   1860

cacttcaatg taatattttc tgtagctcca aaggctatct cttcatattg actgcagaca   1920

gactgaatgg acagtttctt agagggcttg tctcctttct acccttgtcc tctttccttt   1980

cctttgacct aatggagcta gaaatatgtc tgtgactcca ccagttattc taataatttg   2040

ttttcttgaa aattgttaat ttcaagactg gagaaataaa ctcaccttct atttactctg   2100

tgactttatg agaggttgag ggaaaagtgg aagctgtact tgggaattgt ggagaagacc   2160

gccactccat ctgatttgca taaatgactc agtgggcttt tgtatctctt catttaagaa   2220

ttatttgaat gcctgccagg agccagattt gttctgggta ttaggaatac actggttaac   2280

aggaccaaaa aagaccctgc cctcactgag ttttaaattt tagtggagag atggaaaata   2340

attaaacaaa taaacaatgt tatagattgt g                                  2371


<210>  1243
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  1243

Met Leu Leu Arg Ala Ala Trp Arg Arg Ala Ala Val Ala Val Thr Ala 
1               5                   10                  15


Ala Pro Gly Pro Lys Pro Ala Ala Pro Thr Arg Gly Leu Arg Leu Arg 
            20                  25                  30


Val Gly Asp Arg Ala Pro Gln Ser Ala Val Pro Ala Asp Thr Ala Ala 
        35                  40                  45


Ala Pro Glu Val Gly Pro Val Leu Arg Pro Leu Tyr Met Asp Val Gln 
    50                  55                  60


Ala Thr Thr Pro Leu Asp Pro Arg Val Leu Asp Ala Met Leu Pro Tyr 
65                  70                  75                  80


Leu Ile Asn Tyr Tyr Gly Asn Pro His Ser Arg Thr His Ala Tyr Gly 
                85                  90                  95


Trp Glu Ser Glu Ala Ala Met Glu Arg Ala Arg Gln Gln Val Ala Ser 
            100                 105                 110


Leu Ile Gly Ala Asp Pro Arg Glu Ile Ile Phe Thr Ser Gly Ala Thr 
        115                 120                 125


Glu Ser Asn Asn Ile Ala Ile Lys Gly Val Ala Arg Phe Tyr Arg Ser 
    130                 135                 140


Arg Lys Lys His Leu Ile Thr Thr Gln Thr Glu His Lys Cys Val Leu 
145                 150                 155                 160


Asp Ser Cys Arg Ser Leu Glu Ala Glu Gly Phe Gln Val Thr Tyr Leu 
                165                 170                 175


Pro Val Gln Lys Ser Gly Ile Ile Asp Leu Lys Glu Leu Glu Ala Ala 
            180                 185                 190


Ile Gln Pro Asp Thr Ser Leu Val Ser Val Met Thr Val Asn Asn Glu 
        195                 200                 205


Ile Gly Val Lys Gln Pro Ile Ala Glu Ile Gly Arg Ile Cys Ser Ser 
    210                 215                 220


Arg Lys Val Tyr Phe His Thr Asp Ala Ala Gln Ala Val Gly Lys Ile 
225                 230                 235                 240


Pro Leu Asp Val Asn Asp Met Lys Ile Asp Leu Met Ser Ile Ser Gly 
                245                 250                 255


His Lys Ile Tyr Gly Pro Lys Gly Val Gly Ala Ile Tyr Ile Arg Arg 
            260                 265                 270


Arg Pro Arg Val Arg Val Glu Ala Leu Gln Ser Gly Gly Gly Gln Glu 
        275                 280                 285


Arg Gly Met Arg Ser Gly Thr Val Pro Thr Pro Leu Val Val Gly Leu 
    290                 295                 300


Gly Ala Ala Cys Glu Val Ala Gln Gln Glu Met Glu Tyr Asp His Lys 
305                 310                 315                 320


Arg Ile Ser Lys Leu Ser Glu Arg Leu Ile Gln Asn Ile Met Lys Ser 
                325                 330                 335


Leu Pro Asp Val Val Met Asn Gly Asp Pro Lys His His Tyr Pro Gly 
            340                 345                 350


Cys Ile Asn Leu Ser Phe Ala Tyr Val Glu Gly Glu Ser Leu Leu Met 
        355                 360                 365


Ala Leu Lys Asp Val Ala Leu Ser Ser Gly Ser Ala Cys Thr Ser Ala 
    370                 375                 380


Ser Leu Glu Pro Ser Tyr Val Leu Arg Ala Ile Gly Thr Asp Glu Asp 
385                 390                 395                 400


Leu Ala His Ser Ser Ile Arg Phe Gly Ile Gly Arg Phe Thr Thr Glu 
                405                 410                 415


Glu Glu Val Asp Tyr Thr Val Glu Lys Cys Ile Gln His Val Lys Arg 
            420                 425                 430


Leu Arg Glu Met Ser Pro Leu Trp Glu Met Val Gln Asp Gly Ile Asp 
        435                 440                 445


Leu Lys Ser Ile Lys Trp Thr Gln His 
    450                 455


<210>  1244
<211>  477
<212>  DNA
<213>  Homo sapiens

<400>  1244
cttccgaagc cgctgcagtc ctgggcccca ggctcccgga agtgctgccc ggcgctccgg     60

aagcgattca tcgggccgcg agcgccctcc ccgtcgtttt ccgtgagaga cgtagagctg    120

agcgacccag cccgcgagcg aggtgagatg ccggtggccg tgggtcccta cggacagtcc    180

cagccaagct gcttcgaccg tgtcaaaatg ggcttcgtga tgggttgcgc cgtgggcatg    240

gcggccgggg cgctcttcgg caccttttcc tgtctcagga tcggaatgcg gggtcgagag    300

ctgatgggcg gcattgggaa aaccatgatg cagagtggcg gcacctttgg cacattcatg    360

gccattggga tgggcatccg atgctaacca tggttgccaa ctacatctgt cccttcccat    420

caatcccagc ccatgtacta ataaaagaaa gtctttgagt aaaaaaaaaa aaaaaaa       477


<210>  1245
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  1245

Met Pro Val Ala Val Gly Pro Tyr Gly Gln Ser Gln Pro Ser Cys Phe 
1               5                   10                  15


Asp Arg Val Lys Met Gly Phe Val Met Gly Cys Ala Val Gly Met Ala 
            20                  25                  30


Ala Gly Ala Leu Phe Gly Thr Phe Ser Cys Leu Arg Ile Gly Met Arg 
        35                  40                  45


Gly Arg Glu Leu Met Gly Gly Ile Gly Lys Thr Met Met Gln Ser Gly 
    50                  55                  60


Gly Thr Phe Gly Thr Phe Met Ala Ile Gly Met Gly Ile Arg Cys 
65                  70                  75


<210>  1246
<211>  2791
<212>  DNA
<213>  Homo sapiens

<400>  1246
tgtgtgtgtg tatgtgtgct ggtgaatgtg agtacaggga agcagcggcc gccatttcag     60

ggagcttgtc gacgctgtcg caggggtgga tcctgagctg ccgaagccgc cgtcctgctc    120

tcccgcgtgg gcttctctaa ttccattgtt ttttttagat tctctcgggc ctagccgtcc    180

ttggaacccg atattcgggc tgggcggttc cgcggcctgg gcctaggggc ttaacagtag    240

caacagaagc ggcggcggcg gcagcagcag cagcagcagc agcaatctct tcccgaacac    300

gagcaccaca ggcgcccgaa ggccggaaca ggcgtttaga gaaaatggca gacgatattg    360

atattgaagc aatgcttgag gctccttaca agaaggatga gaacaagttg agcagtgcca    420

acggccatga agaacgtagc aaaaagagga aaaaaagcaa gagcagaagt cgtagtcatg    480

aacgaaagag aagcaaaagt aaggaacgga agcgaagtag agacagagaa aggaaaaaga    540

gcaaaagccg tgaaagaaag cgaagtagaa gcaaagagag gcgacggagc cgctcaagaa    600

gtcgagatcg aagatttaga ggccgctaca gaagtcctta ctccggacca aaatttaaca    660

gtgccatccg aggaaagatt gggttgcctc atagcatcaa attaagcaga cgacgttccc    720

gaagcaaaag tccattcaga aaagacaaga gccctgtgag agaacctatt gataatttaa    780

ctcctgagga aagagatgca aggacagtct tctgtatgca gctggcggca agaattcgac    840

caagggattt ggaagagttt ttctctacag taggaaaggt tcgagatgtg aggatgattt    900

ctgacagaaa ttcaagacgt tccaaaggaa ttgcttatgt ggagttcgtc gatgttagct    960

cagtgcctct agcaatagga ttaactggcc aacgagtttt aggcgtgcca atcatagtac   1020

aggcatcaca ggcagaaaaa aacagagctg cagcaatggc aaacaattta caaaagggaa   1080

gtgctggacc tatgaggctt tatgtgggct cattacactt caacataact gaagatatgc   1140

ttcgtgggat ctttgagcct tttggaagaa ttgaaagtat ccagctgatg atggacagtg   1200

aaactggtcg atccaaggga tatggattta ttacattttc tgactcagaa tgtgccaaaa   1260

aggctttgga acaacttaat ggatttgaac tagcaggaag accaatgaaa gttggtcatg   1320

ttactgaacg tactgatgct tcgagtgcta gttcattttt ggacagtgat gaactggaaa   1380

ggactggaat tgatttggga acaactggtc gtcttcagtt aatggcaaga cttgcagagg   1440

gtacaggttt gcagattccg ccagcagcac agcaagctct acagatgagt ggctctttgg   1500

catttggtgc tgtggcagat ttgcaaacaa gactttccca gcagactgaa gcttcagctt   1560

tagctgcagc tgcctctgtt cagccacttg caacacaatg tttccaactc tctaacatgt   1620

ttaaccctca aacagaagaa gaagttggat gggataccga gattaaggat gatgtgattg   1680

aagaatgtaa taaacatgga ggagttattc atatttatgt tgacaaaaat tcagctcagg   1740

gcaatgtgta tgtgaagtgc ccatcaattg ctgcagctat tgctgctgtc aatgcattgc   1800

atggcaggtg gtttgctggt aaaatgataa cagcagcata tgtacctctt ccaacttacc   1860

acaacctgtt tcctgattct atgacagcaa cacagctact ggttccaagt agacgatgaa   1920

ggaagatata gtcccttatg tatatagctt tttttctttc ttgagaattc atcttgagtt   1980

atcttttatt tagataaaaa taaagaggca aggatctact gtcatttgta tgcaatttcc   2040

tgttaccttg aaaaaataaa aatgttaaca ggaatgcagt gtgctcattc tccctaaata   2100

gtaaatccca ctgtatacaa aactgttctc ttgttctgcc ttttaaaatg ttcatgtaga   2160

aaattaatga actataggaa tagctctagg agaacaaatg tgctttctgt aaaaaggcag   2220

accagggatg taatgttttt aatgtttcag aagcctaact ttttacacag tggttacatt   2280

tcacatttca ctaatgttga tatttggctg atggttgagc agtttctgaa atacacattt   2340

agtgtatgga aatacaagac agctaaaggg ctgtttggtt agcatctcat cttgcattct   2400

gatcaattgg caagaaaggg agatttcaaa attatatttc ttgatggtat cttttcaatt   2460

aatgtatctg taaaagtttc tttgtaaata ctatgtgttc tggtgtgtct taaaattcca   2520

aacaaaatga tccctgcatt tcctgaagat gtttaaacgt gagagtctgg taggcaaagc   2580

agtctgagaa agaaatagga aatgcagaaa taggttttgt ctggttgcat ataatctttg   2640

ctctttttaa gctctgtgag ctctgaaata tatttttggg ttacttcagt gtgtttgaca   2700

agacagcttg atatttctat caaacaaatg actttcatat tgcaacaatc tttgtaagaa   2760

ccactcaaat aaaagtctct taaaaaggcc a                                  2791


<210>  1247
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  1247

Met Ala Asp Asp Ile Asp Ile Glu Ala Met Leu Glu Ala Pro Tyr Lys 
1               5                   10                  15


Lys Asp Glu Asn Lys Leu Ser Ser Ala Asn Gly His Glu Glu Arg Ser 
            20                  25                  30


Lys Lys Arg Lys Lys Ser Lys Ser Arg Ser Arg Ser His Glu Arg Lys 
        35                  40                  45


Arg Ser Lys Ser Lys Glu Arg Lys Arg Ser Arg Asp Arg Glu Arg Lys 
    50                  55                  60


Lys Ser Lys Ser Arg Glu Arg Lys Arg Ser Arg Ser Lys Glu Arg Arg 
65                  70                  75                  80


Arg Ser Arg Ser Arg Ser Arg Asp Arg Arg Phe Arg Gly Arg Tyr Arg 
                85                  90                  95


Ser Pro Tyr Ser Gly Pro Lys Phe Asn Ser Ala Ile Arg Gly Lys Ile 
            100                 105                 110


Gly Leu Pro His Ser Ile Lys Leu Ser Arg Arg Arg Ser Arg Ser Lys 
        115                 120                 125


Ser Pro Phe Arg Lys Asp Lys Ser Pro Val Arg Glu Pro Ile Asp Asn 
    130                 135                 140


Leu Thr Pro Glu Glu Arg Asp Ala Arg Thr Val Phe Cys Met Gln Leu 
145                 150                 155                 160


Ala Ala Arg Ile Arg Pro Arg Asp Leu Glu Glu Phe Phe Ser Thr Val 
                165                 170                 175


Gly Lys Val Arg Asp Val Arg Met Ile Ser Asp Arg Asn Ser Arg Arg 
            180                 185                 190


Ser Lys Gly Ile Ala Tyr Val Glu Phe Val Asp Val Ser Ser Val Pro 
        195                 200                 205


Leu Ala Ile Gly Leu Thr Gly Gln Arg Val Leu Gly Val Pro Ile Ile 
    210                 215                 220


Val Gln Ala Ser Gln Ala Glu Lys Asn Arg Ala Ala Ala Met Ala Asn 
225                 230                 235                 240


Asn Leu Gln Lys Gly Ser Ala Gly Pro Met Arg Leu Tyr Val Gly Ser 
                245                 250                 255


Leu His Phe Asn Ile Thr Glu Asp Met Leu Arg Gly Ile Phe Glu Pro 
            260                 265                 270


Phe Gly Arg Ile Glu Ser Ile Gln Leu Met Met Asp Ser Glu Thr Gly 
        275                 280                 285


Arg Ser Lys Gly Tyr Gly Phe Ile Thr Phe Ser Asp Ser Glu Cys Ala 
    290                 295                 300


Lys Lys Ala Leu Glu Gln Leu Asn Gly Phe Glu Leu Ala Gly Arg Pro 
305                 310                 315                 320


Met Lys Val Gly His Val Thr Glu Arg Thr Asp Ala Ser Ser Ala Ser 
                325                 330                 335


Ser Phe Leu Asp Ser Asp Glu Leu Glu Arg Thr Gly Ile Asp Leu Gly 
            340                 345                 350


Thr Thr Gly Arg Leu Gln Leu Met Ala Arg Leu Ala Glu Gly Thr Gly 
        355                 360                 365


Leu Gln Ile Pro Pro Ala Ala Gln Gln Ala Leu Gln Met Ser Gly Ser 
    370                 375                 380


Leu Ala Phe Gly Ala Val Ala Asp Leu Gln Thr Arg Leu Ser Gln Gln 
385                 390                 395                 400


Thr Glu Ala Ser Ala Leu Ala Ala Ala Ala Ser Val Gln Pro Leu Ala 
                405                 410                 415


Thr Gln Cys Phe Gln Leu Ser Asn Met Phe Asn Pro Gln Thr Glu Glu 
            420                 425                 430


Glu Val Gly Trp Asp Thr Glu Ile Lys Asp Asp Val Ile Glu Glu Cys 
        435                 440                 445


Asn Lys His Gly Gly Val Ile His Ile Tyr Val Asp Lys Asn Ser Ala 
    450                 455                 460


Gln Gly Asn Val Tyr Val Lys Cys Pro Ser Ile Ala Ala Ala Ile Ala 
465                 470                 475                 480


Ala Val Asn Ala Leu His Gly Arg Trp Phe Ala Gly Lys Met Ile Thr 
                485                 490                 495


Ala Ala Tyr Val Pro Leu Pro Thr Tyr His Asn Leu Phe Pro Asp Ser 
            500                 505                 510


Met Thr Ala Thr Gln Leu Leu Val Pro Ser Arg Arg 
        515                 520


<210>  1248
<211>  2809
<212>  DNA
<213>  Homo sapiens

<400>  1248
tgtgtgtgtg tatgtgtgct ggtgaatgtg agtacaggga agcagcggcc gccatttcag     60

ggagcttgtc gacgctgtcg caggggtgga tcctgagctg ccgaagccgc cgtcctgctc    120

tcccgcgtgg gcttctctaa ttccattgtt ttttttagat tctctcgggc ctagccgtcc    180

ttggaacccg atattcgggc tgggcggttc cgcggcctgg gcctaggggc ttaacagtag    240

caacagaagc ggcggcggcg gcagcagcag cagcagcagc agcaatctct tcccgaacac    300

gagcaccaca ggcgcccgaa ggccggaaca ggcgtttaga gaaaatggca gacgatattg    360

atattgaagc aatgcttgag gctccttaca agaaggatga gaacaagttg agcagtgcca    420

acggccatga agaacgtagc aaaaagagga aaaaaagcaa gagcagaagt cgtagtcatg    480

aacgaaagag aagcaaaagt aaggaacgga agcgaagtag agacagagaa aggaaaaaga    540

gcaaaagccg tgaaagaaag cgaagtagaa gcaaagagag gcgacggagc cgctcaagaa    600

gtcgagatcg aagatttaga ggccgctaca gaagtcctta ctccggacca aaatttaaca    660

gtgccatccg aggaaagatt gggttgcctc atagcatcaa attaagcaga cgacgttccc    720

gaagcaaaag tccattcaga aaagacaaga gccctgtgag agaacctatt gataatttaa    780

ctcctgagga aagagatgca aggacagtct tctgtatgca gctggcggca agaattcgac    840

caagggattt ggaagagttt ttctctacag taggaaaggt tcgagatgtg aggatgattt    900

ctgacagaaa ttcaagacgt tccaaaggaa ttgcttatgt ggagttcgtc gatgttagct    960

cagtgcctct agcaatagga ttaactggcc aacgagtttt aggcgtgcca atcatagtac   1020

aggcatcaca ggcagaaaaa aacagagctg cagcaatggc aaacaattta caaaagggaa   1080

gtgctggacc tatgaggctt tatgtgggct cattacactt caacataact gaagatatgc   1140

ttcgtgggat ctttgagcct tttggaagaa ttgaaagtat ccagctgatg atggacagtg   1200

aaactggtcg atccaaggga tatggattta ttacattttc tgactcagaa tgtgccaaaa   1260

aggctttgga acaacttaat ggatttgaac tagcaggaag accaatgaaa gttggtcatg   1320

ttactgaacg tactgatgct tcgagtgcta gttcattttt ggacagtgat gaactggaaa   1380

ggactggaat tgatttggga acaactggtc gtcttcagtt aatggcaaga cttgcagagg   1440

gtacaggttt gcagattccg ccagcagcac agcaagctct acagatgagt ggctctttgg   1500

catttggtgc tgtggcagaa ttctcttttg ttatagattt gcaaacaaga ctttcccagc   1560

agactgaagc ttcagcttta gctgcagctg cctctgttca gccacttgca acacaatgtt   1620

tccaactctc taacatgttt aaccctcaaa cagaagaaga agttggatgg gataccgaga   1680

ttaaggatga tgtgattgaa gaatgtaata aacatggagg agttattcat atttatgttg   1740

acaaaaattc agctcagggc aatgtgtatg tgaagtgccc atcaattgct gcagctattg   1800

ctgctgtcaa tgcattgcat ggcaggtggt ttgctggtaa aatgataaca gcagcatatg   1860

tacctcttcc aacttaccac aacctgtttc ctgattctat gacagcaaca cagctactgg   1920

ttccaagtag acgatgaagg aagatatagt cccttatgta tatagctttt tttctttctt   1980

gagaattcat cttgagttat cttttattta gataaaaata aagaggcaag gatctactgt   2040

catttgtatg caatttcctg ttaccttgaa aaaataaaaa tgttaacagg aatgcagtgt   2100

gctcattctc cctaaatagt aaatcccact gtatacaaaa ctgttctctt gttctgcctt   2160

ttaaaatgtt catgtagaaa attaatgaac tataggaata gctctaggag aacaaatgtg   2220

ctttctgtaa aaaggcagac cagggatgta atgtttttaa tgtttcagaa gcctaacttt   2280

ttacacagtg gttacatttc acatttcact aatgttgata tttggctgat ggttgagcag   2340

tttctgaaat acacatttag tgtatggaaa tacaagacag ctaaagggct gtttggttag   2400

catctcatct tgcattctga tcaattggca agaaagggag atttcaaaat tatatttctt   2460

gatggtatct tttcaattaa tgtatctgta aaagtttctt tgtaaatact atgtgttctg   2520

gtgtgtctta aaattccaaa caaaatgatc cctgcatttc ctgaagatgt ttaaacgtga   2580

gagtctggta ggcaaagcag tctgagaaag aaataggaaa tgcagaaata ggttttgtct   2640

ggttgcatat aatctttgct ctttttaagc tctgtgagct ctgaaatata tttttgggtt   2700

acttcagtgt gtttgacaag acagcttgat atttctatca aacaaatgac tttcatattg   2760

caacaatctt tgtaagaacc actcaaataa aagtctctta aaaaggcca               2809


<210>  1249
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  1249

Met Ala Asp Asp Ile Asp Ile Glu Ala Met Leu Glu Ala Pro Tyr Lys 
1               5                   10                  15


Lys Asp Glu Asn Lys Leu Ser Ser Ala Asn Gly His Glu Glu Arg Ser 
            20                  25                  30


Lys Lys Arg Lys Lys Ser Lys Ser Arg Ser Arg Ser His Glu Arg Lys 
        35                  40                  45


Arg Ser Lys Ser Lys Glu Arg Lys Arg Ser Arg Asp Arg Glu Arg Lys 
    50                  55                  60


Lys Ser Lys Ser Arg Glu Arg Lys Arg Ser Arg Ser Lys Glu Arg Arg 
65                  70                  75                  80


Arg Ser Arg Ser Arg Ser Arg Asp Arg Arg Phe Arg Gly Arg Tyr Arg 
                85                  90                  95


Ser Pro Tyr Ser Gly Pro Lys Phe Asn Ser Ala Ile Arg Gly Lys Ile 
            100                 105                 110


Gly Leu Pro His Ser Ile Lys Leu Ser Arg Arg Arg Ser Arg Ser Lys 
        115                 120                 125


Ser Pro Phe Arg Lys Asp Lys Ser Pro Val Arg Glu Pro Ile Asp Asn 
    130                 135                 140


Leu Thr Pro Glu Glu Arg Asp Ala Arg Thr Val Phe Cys Met Gln Leu 
145                 150                 155                 160


Ala Ala Arg Ile Arg Pro Arg Asp Leu Glu Glu Phe Phe Ser Thr Val 
                165                 170                 175


Gly Lys Val Arg Asp Val Arg Met Ile Ser Asp Arg Asn Ser Arg Arg 
            180                 185                 190


Ser Lys Gly Ile Ala Tyr Val Glu Phe Val Asp Val Ser Ser Val Pro 
        195                 200                 205


Leu Ala Ile Gly Leu Thr Gly Gln Arg Val Leu Gly Val Pro Ile Ile 
    210                 215                 220


Val Gln Ala Ser Gln Ala Glu Lys Asn Arg Ala Ala Ala Met Ala Asn 
225                 230                 235                 240


Asn Leu Gln Lys Gly Ser Ala Gly Pro Met Arg Leu Tyr Val Gly Ser 
                245                 250                 255


Leu His Phe Asn Ile Thr Glu Asp Met Leu Arg Gly Ile Phe Glu Pro 
            260                 265                 270


Phe Gly Arg Ile Glu Ser Ile Gln Leu Met Met Asp Ser Glu Thr Gly 
        275                 280                 285


Arg Ser Lys Gly Tyr Gly Phe Ile Thr Phe Ser Asp Ser Glu Cys Ala 
    290                 295                 300


Lys Lys Ala Leu Glu Gln Leu Asn Gly Phe Glu Leu Ala Gly Arg Pro 
305                 310                 315                 320


Met Lys Val Gly His Val Thr Glu Arg Thr Asp Ala Ser Ser Ala Ser 
                325                 330                 335


Ser Phe Leu Asp Ser Asp Glu Leu Glu Arg Thr Gly Ile Asp Leu Gly 
            340                 345                 350


Thr Thr Gly Arg Leu Gln Leu Met Ala Arg Leu Ala Glu Gly Thr Gly 
        355                 360                 365


Leu Gln Ile Pro Pro Ala Ala Gln Gln Ala Leu Gln Met Ser Gly Ser 
    370                 375                 380


Leu Ala Phe Gly Ala Val Ala Glu Phe Ser Phe Val Ile Asp Leu Gln 
385                 390                 395                 400


Thr Arg Leu Ser Gln Gln Thr Glu Ala Ser Ala Leu Ala Ala Ala Ala 
                405                 410                 415


Ser Val Gln Pro Leu Ala Thr Gln Cys Phe Gln Leu Ser Asn Met Phe 
            420                 425                 430


Asn Pro Gln Thr Glu Glu Glu Val Gly Trp Asp Thr Glu Ile Lys Asp 
        435                 440                 445


Asp Val Ile Glu Glu Cys Asn Lys His Gly Gly Val Ile His Ile Tyr 
    450                 455                 460


Val Asp Lys Asn Ser Ala Gln Gly Asn Val Tyr Val Lys Cys Pro Ser 
465                 470                 475                 480


Ile Ala Ala Ala Ile Ala Ala Val Asn Ala Leu His Gly Arg Trp Phe 
                485                 490                 495


Ala Gly Lys Met Ile Thr Ala Ala Tyr Val Pro Leu Pro Thr Tyr His 
            500                 505                 510


Asn Leu Phe Pro Asp Ser Met Thr Ala Thr Gln Leu Leu Val Pro Ser 
        515                 520                 525


Arg Arg 
    530


<210>  1250
<211>  986
<212>  DNA
<213>  Homo sapiens

<400>  1250
atggataaac cattgcaaat taggaggcag aagttccagg tagtggtagc gatagatgct     60

ctggatcgag ttgtaaagcc caaaatgaaa agagtcaaga gattccttga gaagagagaa    120

ccaaaactca atgaaaatat taaaaatgca atgctgatta aagggggaaa tgcaaacgca    180

acagtgacac aagtacttaa agatgtgtgt gcactgaaaa aaccatacgg tgtactgtat    240

aaaaagaaaa atgttacaag accttttgag gatcagacat cactggaatt actttcaaag    300

aagtcagatt gttctttatt catgtttggc tcctataata agaagcggcc aaataatcta    360

gtaataggtc atatgtatga ctaccatgtg ctggatatga ttgaattagg tattgagaat    420

tttgtctctc taaaagacat taagaacagt aaatgtcctg agggaacaaa acccatgcta    480

atatttgctg gtgatgattt caatgtaaca gaagattaca gaagactaaa aagtcttctt    540

actgatttct tcagaggccc cacagtatca aatatctgcc tggctggatt agaatatgtt    600

ctgcacttca ctgcactgaa tgggaagatt tactttcgaa gatataagtt gctgttgaag    660

aaatctggtt gcagaacacc acggattgaa ttggaagaga taggaccctc attgaatctg    720

gttctgagga ggacacacct ggcatccgat gacctttata cattatctat gaaaatgcca    780

aaagctctca agccaaagaa gaagaaaaat atctccaatg atacttttgg tacaacttat    840

ggaaggattc atatgtagaa cgaagataag caaactacaa accaggaaaa tgaaggggtt    900

gaagaagtga cctgcagaaa ggataacaga agaccaggag aaaaagtcaa aaagaattta    960

aaagaaatta tggaaaaaaa aaaaaa                                         986


<210>  1251
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  1251

Met Asp Lys Pro Leu Gln Ile Arg Arg Gln Lys Phe Gln Val Val Val 
1               5                   10                  15


Ala Ile Asp Ala Leu Asp Arg Val Val Lys Pro Lys Met Lys Arg Val 
            20                  25                  30


Lys Arg Phe Leu Glu Lys Arg Glu Pro Lys Leu Asn Glu Asn Ile Lys 
        35                  40                  45


Asn Ala Met Leu Ile Lys Gly Gly Asn Ala Asn Ala Thr Val Thr Gln 
    50                  55                  60


Val Leu Lys Asp Val Cys Ala Leu Lys Lys Pro Tyr Gly Val Leu Tyr 
65                  70                  75                  80


Lys Lys Lys Asn Val Thr Arg Pro Phe Glu Asp Gln Thr Ser Leu Glu 
                85                  90                  95


Leu Leu Ser Lys Lys Ser Asp Cys Ser Leu Phe Met Phe Gly Ser Tyr 
            100                 105                 110


Asn Lys Lys Arg Pro Asn Asn Leu Val Ile Gly His Met Tyr Asp Tyr 
        115                 120                 125


His Val Leu Asp Met Ile Glu Leu Gly Ile Glu Asn Phe Val Ser Leu 
    130                 135                 140


Lys Asp Ile Lys Asn Ser Lys Cys Pro Glu Gly Thr Lys Pro Met Leu 
145                 150                 155                 160


Ile Phe Ala Gly Asp Asp Phe Asn Val Thr Glu Asp Tyr Arg Arg Leu 
                165                 170                 175


Lys Ser Leu Leu Thr Asp Phe Phe Arg Gly Pro Thr Val Ser Asn Ile 
            180                 185                 190


Cys Leu Ala Gly Leu Glu Tyr Val Leu His Phe Thr Ala Leu Asn Gly 
        195                 200                 205


Lys Ile Tyr Phe Arg Arg Tyr Lys Leu Leu Leu Lys Lys Ser Gly Cys 
    210                 215                 220


Arg Thr Pro Arg Ile Glu Leu Glu Glu Ile Gly Pro Ser Leu Asn Leu 
225                 230                 235                 240


Val Leu Arg Arg Thr His Leu Ala Ser Asp Asp Leu Tyr Thr Leu Ser 
                245                 250                 255


Met Lys Met Pro Lys Ala Leu Lys Pro Lys Lys Lys Lys Asn Ile Ser 
            260                 265                 270


Asn Asp Thr Phe Gly Thr Thr Tyr Gly Arg Ile His Met 
        275                 280                 285


<210>  1252
<211>  5899
<212>  DNA
<213>  Homo sapiens

<400>  1252
gggggtcacg tggtgcagag cacgcagagt ccttctgtcg gttggtcctg gagcggcgca     60

gccggagtgg ggccgtgagg agaataaagg cagccccgtt gatgactgaa aatgacaaag    120

catccaccta acagacgagg aatcagcttt gaagtgggag cccagttgga agcccgggac    180

cgtttaaaaa actggtatcc agctcacata gaagacattg actacgagga aggaaaagta    240

ctcatccatt tcaagcgttg gaaccatcgt tatgatgagt ggttctgctg ggacagtcct    300

tatttacgcc ctttagagaa aatacagctg aggaaagagg gcttgcatga agaggatgga    360

tcttctgaat ttcaaataaa tgagcaggtc cttgcttgct ggtctgattg tcgtttttac    420

ccggccaaag tcactgctgt taacaaggat ggtacttaca ctgtgaaatt ttatgatgga    480

gtagttcaga ctgtcaaaca tattcatgtc aaagcttttt ccaaagatca gaatattgtg    540

ggtaatgcta ggcctaaaga aacagatcac aaaagtcttt catcatctcc tgataaacga    600

gagaagttta aagaacagag aaaagcaaca gtgaatgtga agaaagacaa agaagataaa    660

cccttaaaga cagaaaagcg acccaagcag cctgataaag aaggaaagtt aatctgttct    720

gaaaagggga aagtgtcaga gaaaagtctt cccaagaacg agaaggaaga caaggaaaac    780

atttccgaaa atgacagaga gtattctgga gatgcccaag tggataagaa acctgaaaat    840

gacattgtga agagtccaca agaaaacttg agggaaccca aaagaaaacg aggcagaccc    900

ccttccatag ctcctactgc tgtggattca aactctcaaa ctttgcaacc aataacattg    960

gaactgagaa gaaggaaaat atcaaaagga tgtgaagtcc cattaaaacg tcctcggctt   1020

gacaaaaatt catcccagga aaagtcaaaa aactactcgg aaaacactga caaagactta   1080

tcgaggagac gttcctccag gctgtccact aatgggaccc atgagatcct agatcctgac   1140

ttggttgtat cagatttggt tgatacggat cctttgcaag acacgttgtc tagtaccaag   1200

gaatctgaag aaggtcagtt gaagtctgct ttggaagctg gccaggtctc atctgcactg   1260

acttgccact cctttgggga tggatccggg gctgcaggct tggagttgaa ctgcccatca   1320

atgggagaaa acacgatgaa aacagaaccg acttctcccc ttgtggaatt acaagagatt   1380

tcgactgtgg aagtaacaaa tacttttaag aaaacagatg attttgggtc atctaatgca   1440

ccagctgtcg acctagacca taagtttaga tgcaaagttg tggactgttt aaaatttttc   1500

cgcaaagcca aactgttgca ctatcacatg aagtatttcc atggaatgga gaagtcactg   1560

gagccagaag agagcccggg aaagaggcat gtccaaacca ggggcccttc agcttcagac   1620

aagcccagcc aggagaccct gaccaggaag cgggtctctg ccagttcccc aactacaaaa   1680

gacaaggaaa agaataaaga gaagaaattc aaggagtttg tgagagtgaa gccaaagaag   1740

aaaaagaaaa agaaaaagaa aaccaaacct gaatgcccct gcagtgagga gatcagtgac   1800

acctcccagg aaccttctcc acccaaggca tttgctgtta ccaggtgtgg gtcctcacac   1860

aagccagggg tccatatgag cccgcagctt catggcccag aatctggaca ccacaaaggg   1920

aaagtgaaag cattggagga ggataatttg agtgagtcct cttctgagag ctttctctgg   1980

agtgatgatg agtatggcca agatgtggat gtgaccacca acccagatga ggaacttgat   2040

ggggatgacc gctatgactt cgaggtggtc cgctgcatct gtgaggtcca ggaggaaaat   2100

gacttcatga ttcagtgtga agagtgccag tgctggcagc atggggtctg catgggatta   2160

ctggaagaaa atgtgcccga gaaatacacc tgttatgttt gccaagaccc tccaggtcag   2220

aggcctggct tcaagtactg gtatgacaag gagtggctga gcaggggaca tatgcatggc   2280

ctggcatttc tagaagagaa ctactcccat cagaatgcca agaagatcgt ggccacccac   2340

cagcttcttg gtgatgtgca gagagtgatt gaggttctgc atggcctgca gctcaagatg   2400

agcatcttgc aaagccggga gcatcctgat ctgccgctgt ggtgccagcc ttggaaacag   2460

cactcagggg aggggagatc tcatttcaga aacatccctg tcactgacac caggagcaag   2520

gaggaagctc caagctatag aactttgaac ggggcagtgg agaagcccag gcccctggcc   2580

ctgcccctgc cgcgttctgt ggaggaatcc tatatcacca gtgagcattg ctaccagaag   2640

ccccgcgcct attaccctgc cgtggagcag aagctggtgg tggagacgag gggctctgcc   2700

ctcgacgatg cggtcaaccc cctccatgag aacggcgatg attccctttc cccgcgcctg   2760

ggctggcctc tagaccaaga caggagcaag ggggacagtg accccaaacc cggctcccca   2820

aaggtgaagg aatatgtctc caaaaaggcc ctaccagaag aagcccctgc tcggaagctg   2880

ctggacagag gtggagaggg gctgctgagc tcccagcacc agtggcagtt taacctgctg   2940

acccatgtgg aatctcttca ggatgaagtt acgcacagga tggactccat tgagaaggag   3000

ttggatgtgt tggagagctg gctggactac actggggaac tggagccccc tgagccgctg   3060

gccaggcttc cgcagctcaa gcattgtatc aagcagctgc tgatggacct gggcaaggtg   3120

cagcagatcg ccctctgctg ctcaacatga aactgggcac ccaaaactca tgggggcaca   3180

atcctggggc acctgcagga ggagcttcgc atatttaaat aaataaacct agcatgctga   3240

atgcacgtga caccgactga cttcagggat ctgggccagg agtgtggtgg acattggaca   3300

aagaggccat tttggctgcg ggaggacact ctgatctcga agcctgccat aaaggtagca   3360

aatagactct tgggattccc ctcttctgtg cacatcgttg aatgaagaga gtctttttgc   3420

acaaacttca cttgaaattg tgccactgat gataaacgga atgagagcca aaaaagttta   3480

gttggagaca gttgtaaatt caatttggag tttatttaat tgacttttct atcacgttgg   3540

ggcacatgcc aactccctgg tttcttcctg gcatggtgtt tgggcagcag gcatcatttt   3600

ccttttctag cttcatagga atattgtgag ctcaccatgc tgtggaggtt gggaaagagc   3660

agagtcttgg ctgccctgct ttctccttag gactcttcac ttttctcacc acatctcttg   3720

catgacttca tggtactggg gacaagtttg tatgccttca ccccagagct ggctgggtta   3780

tggcttttgt agcagagccc atacagccta tggaagaact agaatctcac tcacagtaat   3840

aagaatctag gaggaattcc aaaccgaagc aggcagggtc tggaacccaa aggacagcat   3900

tttctaccca cttcttaata ttgacagctt ccccgttcta tttaatgtcc aaaaatgttt   3960

cccaaaattt caaactcttt cactgtaaag atttgttaca aagaatgtgg tttggggaat   4020

taccttattt tatattgttg taaacaaact tcaaattcta catgtgcgac ttttctcctt   4080

cctgaagggt gtttagtagt cagcgttttc agaattgttt tgttactata ctttaacatt   4140

ttacatttcc tgtttgtatt attttgtgag agcaaggtga tcatgctgct taaggtccag   4200

gtacaaccta tttgtacctt ttgagacaat atttgtgtta cttttgcagg ttacggttcc   4260

acatgtaatt gctatatttt gttttgtttt tccttactag gcaaagttaa aatgttccat   4320

gctttgagga gtgacccatt tcactacttt gttttcttat cactaaaggc aaaaatcaaa   4380

gcacagttgt ccattaacac ttataagtta attatgggtt tatgagtctg taatgttata   4440

tgctgcaaac atttactatg taaacgtgaa gtagccaata atatctcaat agtagtaaca   4500

gtatctttag cgacctttgg aatagttaag cacaggtcat tgtggacatg aattcaggcc   4560

tctgtactaa aatctatttc agggaatgtt ctgtctagtg atttgctcac catttgatat   4620

ataatgaatt ataggacaag tataagctga tctgctatag ctgtccatca gagagaatac   4680

acgtggctat aacatctata acaaaacgac gattcctcta caagaggctg tttctcactg   4740

ctaacgttgg tgtttctggc gtgggaagaa atgcacaggc gtgcatggca tgcacgttca   4800

gacagctgca ttgtaagagt tctgtcatgc agtctgaaaa gggaagaaac aggatggctt   4860

tctgtagcca cacctgtgag gcgtgatgat tgttgtatta ttagattact gatttttctt   4920

ttctgaaaat acatttgagt tttaatcaca tctgtggaag ctgtaacttt taaggtagtc   4980

aatttcatgt cttgttcaac gatgtaagca gaaactgaat tgccctaatt ttgccaactg   5040

gccattattg ggattattgt ttaaattttt ggtaaaggaa gtaatctcct ttcattcatt   5100

gtgacttttg ttcttaggga agcagagaag actccccaag ttcttataac ctcattgtgc   5160

ttccctaatt taaagccatg ttgaggggct ccattcccaa ttcctgggtc aaggtgaatt   5220

aaccctatgt tggagcactg gaaaccgtta tttgcaaaca ttgctgttac catttagaaa   5280

tatgtgcact atcagctggg tgcagtggct cacgtctgta atcccagcac tttgggaggc   5340

cgaggcaggt ggatcacctg aggtcaggag ttcgagacca gcctggccaa cagggtgaaa   5400

ccccgtctct actaaaagta caaaaattag ctgggcgtgg tggcggacgc ctgtaatctc   5460

agctacttgg gaggctgaag caggagaggt gctggaacct gggaggcgga ggttgaagtg   5520

agccgagatt gcgctattgc actccagctc gggcgacaac tgcaagactc catctcaaaa   5580

aaataaaaat aaaagaaaag aaagaaatat gtgcactacc taagttttgt ctttagaaaa   5640

actatccacc tataaaaaat taccttgaca aaaatagttc cggtttgact aatcattttg   5700

tttctttaag tggtaagtgt atgcaaggtg gatccttgat gagccaacat tgcactgtgg   5760

atacatatct atgtttacgc gctattagaa cagaaggcgc tgtatataga aatgttgctt   5820

tgaagcaata tttgcaaaac acgcagactt ctgtatctgt atttggaaaa aataaaacag   5880

gttcttgtta aaaaaaaaa                                                5899


<210>  1253
<211>  1012
<212>  PRT
<213>  Homo sapiens

<400>  1253

Met Thr Lys His Pro Pro Asn Arg Arg Gly Ile Ser Phe Glu Val Gly 
1               5                   10                  15


Ala Gln Leu Glu Ala Arg Asp Arg Leu Lys Asn Trp Tyr Pro Ala His 
            20                  25                  30


Ile Glu Asp Ile Asp Tyr Glu Glu Gly Lys Val Leu Ile His Phe Lys 
        35                  40                  45


Arg Trp Asn His Arg Tyr Asp Glu Trp Phe Cys Trp Asp Ser Pro Tyr 
    50                  55                  60


Leu Arg Pro Leu Glu Lys Ile Gln Leu Arg Lys Glu Gly Leu His Glu 
65                  70                  75                  80


Glu Asp Gly Ser Ser Glu Phe Gln Ile Asn Glu Gln Val Leu Ala Cys 
                85                  90                  95


Trp Ser Asp Cys Arg Phe Tyr Pro Ala Lys Val Thr Ala Val Asn Lys 
            100                 105                 110


Asp Gly Thr Tyr Thr Val Lys Phe Tyr Asp Gly Val Val Gln Thr Val 
        115                 120                 125


Lys His Ile His Val Lys Ala Phe Ser Lys Asp Gln Asn Ile Val Gly 
    130                 135                 140


Asn Ala Arg Pro Lys Glu Thr Asp His Lys Ser Leu Ser Ser Ser Pro 
145                 150                 155                 160


Asp Lys Arg Glu Lys Phe Lys Glu Gln Arg Lys Ala Thr Val Asn Val 
                165                 170                 175


Lys Lys Asp Lys Glu Asp Lys Pro Leu Lys Thr Glu Lys Arg Pro Lys 
            180                 185                 190


Gln Pro Asp Lys Glu Gly Lys Leu Ile Cys Ser Glu Lys Gly Lys Val 
        195                 200                 205


Ser Glu Lys Ser Leu Pro Lys Asn Glu Lys Glu Asp Lys Glu Asn Ile 
    210                 215                 220


Ser Glu Asn Asp Arg Glu Tyr Ser Gly Asp Ala Gln Val Asp Lys Lys 
225                 230                 235                 240


Pro Glu Asn Asp Ile Val Lys Ser Pro Gln Glu Asn Leu Arg Glu Pro 
                245                 250                 255


Lys Arg Lys Arg Gly Arg Pro Pro Ser Ile Ala Pro Thr Ala Val Asp 
            260                 265                 270


Ser Asn Ser Gln Thr Leu Gln Pro Ile Thr Leu Glu Leu Arg Arg Arg 
        275                 280                 285


Lys Ile Ser Lys Gly Cys Glu Val Pro Leu Lys Arg Pro Arg Leu Asp 
    290                 295                 300


Lys Asn Ser Ser Gln Glu Lys Ser Lys Asn Tyr Ser Glu Asn Thr Asp 
305                 310                 315                 320


Lys Asp Leu Ser Arg Arg Arg Ser Ser Arg Leu Ser Thr Asn Gly Thr 
                325                 330                 335


His Glu Ile Leu Asp Pro Asp Leu Val Val Ser Asp Leu Val Asp Thr 
            340                 345                 350


Asp Pro Leu Gln Asp Thr Leu Ser Ser Thr Lys Glu Ser Glu Glu Gly 
        355                 360                 365


Gln Leu Lys Ser Ala Leu Glu Ala Gly Gln Val Ser Ser Ala Leu Thr 
    370                 375                 380


Cys His Ser Phe Gly Asp Gly Ser Gly Ala Ala Gly Leu Glu Leu Asn 
385                 390                 395                 400


Cys Pro Ser Met Gly Glu Asn Thr Met Lys Thr Glu Pro Thr Ser Pro 
                405                 410                 415


Leu Val Glu Leu Gln Glu Ile Ser Thr Val Glu Val Thr Asn Thr Phe 
            420                 425                 430


Lys Lys Thr Asp Asp Phe Gly Ser Ser Asn Ala Pro Ala Val Asp Leu 
        435                 440                 445


Asp His Lys Phe Arg Cys Lys Val Val Asp Cys Leu Lys Phe Phe Arg 
    450                 455                 460


Lys Ala Lys Leu Leu His Tyr His Met Lys Tyr Phe His Gly Met Glu 
465                 470                 475                 480


Lys Ser Leu Glu Pro Glu Glu Ser Pro Gly Lys Arg His Val Gln Thr 
                485                 490                 495


Arg Gly Pro Ser Ala Ser Asp Lys Pro Ser Gln Glu Thr Leu Thr Arg 
            500                 505                 510


Lys Arg Val Ser Ala Ser Ser Pro Thr Thr Lys Asp Lys Glu Lys Asn 
        515                 520                 525


Lys Glu Lys Lys Phe Lys Glu Phe Val Arg Val Lys Pro Lys Lys Lys 
    530                 535                 540


Lys Lys Lys Lys Lys Lys Thr Lys Pro Glu Cys Pro Cys Ser Glu Glu 
545                 550                 555                 560


Ile Ser Asp Thr Ser Gln Glu Pro Ser Pro Pro Lys Ala Phe Ala Val 
                565                 570                 575


Thr Arg Cys Gly Ser Ser His Lys Pro Gly Val His Met Ser Pro Gln 
            580                 585                 590


Leu His Gly Pro Glu Ser Gly His His Lys Gly Lys Val Lys Ala Leu 
        595                 600                 605


Glu Glu Asp Asn Leu Ser Glu Ser Ser Ser Glu Ser Phe Leu Trp Ser 
    610                 615                 620


Asp Asp Glu Tyr Gly Gln Asp Val Asp Val Thr Thr Asn Pro Asp Glu 
625                 630                 635                 640


Glu Leu Asp Gly Asp Asp Arg Tyr Asp Phe Glu Val Val Arg Cys Ile 
                645                 650                 655


Cys Glu Val Gln Glu Glu Asn Asp Phe Met Ile Gln Cys Glu Glu Cys 
            660                 665                 670


Gln Cys Trp Gln His Gly Val Cys Met Gly Leu Leu Glu Glu Asn Val 
        675                 680                 685


Pro Glu Lys Tyr Thr Cys Tyr Val Cys Gln Asp Pro Pro Gly Gln Arg 
    690                 695                 700


Pro Gly Phe Lys Tyr Trp Tyr Asp Lys Glu Trp Leu Ser Arg Gly His 
705                 710                 715                 720


Met His Gly Leu Ala Phe Leu Glu Glu Asn Tyr Ser His Gln Asn Ala 
                725                 730                 735


Lys Lys Ile Val Ala Thr His Gln Leu Leu Gly Asp Val Gln Arg Val 
            740                 745                 750


Ile Glu Val Leu His Gly Leu Gln Leu Lys Met Ser Ile Leu Gln Ser 
        755                 760                 765


Arg Glu His Pro Asp Leu Pro Leu Trp Cys Gln Pro Trp Lys Gln His 
    770                 775                 780


Ser Gly Glu Gly Arg Ser His Phe Arg Asn Ile Pro Val Thr Asp Thr 
785                 790                 795                 800


Arg Ser Lys Glu Glu Ala Pro Ser Tyr Arg Thr Leu Asn Gly Ala Val 
                805                 810                 815


Glu Lys Pro Arg Pro Leu Ala Leu Pro Leu Pro Arg Ser Val Glu Glu 
            820                 825                 830


Ser Tyr Ile Thr Ser Glu His Cys Tyr Gln Lys Pro Arg Ala Tyr Tyr 
        835                 840                 845


Pro Ala Val Glu Gln Lys Leu Val Val Glu Thr Arg Gly Ser Ala Leu 
    850                 855                 860


Asp Asp Ala Val Asn Pro Leu His Glu Asn Gly Asp Asp Ser Leu Ser 
865                 870                 875                 880


Pro Arg Leu Gly Trp Pro Leu Asp Gln Asp Arg Ser Lys Gly Asp Ser 
                885                 890                 895


Asp Pro Lys Pro Gly Ser Pro Lys Val Lys Glu Tyr Val Ser Lys Lys 
            900                 905                 910


Ala Leu Pro Glu Glu Ala Pro Ala Arg Lys Leu Leu Asp Arg Gly Gly 
        915                 920                 925


Glu Gly Leu Leu Ser Ser Gln His Gln Trp Gln Phe Asn Leu Leu Thr 
    930                 935                 940


His Val Glu Ser Leu Gln Asp Glu Val Thr His Arg Met Asp Ser Ile 
945                 950                 955                 960


Glu Lys Glu Leu Asp Val Leu Glu Ser Trp Leu Asp Tyr Thr Gly Glu 
                965                 970                 975


Leu Glu Pro Pro Glu Pro Leu Ala Arg Leu Pro Gln Leu Lys His Cys 
            980                 985                 990


Ile Lys Gln Leu Leu Met Asp Leu Gly Lys Val Gln Gln Ile Ala Leu 
        995                 1000                1005


Cys Cys Ser Thr 
    1010


<210>  1254
<211>  916
<212>  DNA
<213>  Homo sapiens

<400>  1254
ggacgcagag aagccagaga ctttcgcttc cggctgccgc aggcgcttcg ctggtgcagg     60

taagctccgc acactctcgg ccggtcccga gtccgactcc ctcaagggtg acgcgagctc    120

tgccctttaa ccggaaacgt ctccctgctc accccacccc cgcgcagacg cagtgctgag    180

cacacagcta ccggacaaag agtgacgccc ggagctggag ttatggcggc tacggagccg    240

atcttggcgg ccactgggag tcccgcggcg gtgccaccgg agaaactgga aggagccggt    300

tcgagctcag cccctgagcg taactgtgtg ggctcctcgc tgccagaggc ctcaccgcct    360

gcccctgagc cttccagtcc caacgccgcg gtccctgaag ccatccctac gccccgagct    420

gcggcctccg cggccctgga gctgcctctc gggcccgcac ccgtgagcgt agcgcctcag    480

gccgaagctg aagcgcgctc cacaccaggc cccgccggct ctagactcgg tcccgagacg    540

ttccgccagc gtttccggca gttccgctac caggatgcgg cgggtccccg ggaggctttc    600

cggcagctgc gggagctgtc ccgccagtgg ctgcggcctg acatccgcac caaggagcag    660

atcgtggaga tgctggtgca agagcagctg ctcgccatcc tgcccgaggc ggctcgggcc    720

cggcggatcc gccgccgcac ggatgtgcgc atcactggct gagcggtgga gctgcgggcg    780

gccagggccg ggcgctctgt gcggactggg gccatgatcg ggcccggggg cctgagcctg    840

ggaccccacc ccgtgttaat gaaaaatgag ttttggcagc gccaaaaaaa aaaaaaaaaa    900

aaaaaaaaaa aaaaaa                                                    916


<210>  1255
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  1255

Met Ala Ala Thr Glu Pro Ile Leu Ala Ala Thr Gly Ser Pro Ala Ala 
1               5                   10                  15


Val Pro Pro Glu Lys Leu Glu Gly Ala Gly Ser Ser Ser Ala Pro Glu 
            20                  25                  30


Arg Asn Cys Val Gly Ser Ser Leu Pro Glu Ala Ser Pro Pro Ala Pro 
        35                  40                  45


Glu Pro Ser Ser Pro Asn Ala Ala Val Pro Glu Ala Ile Pro Thr Pro 
    50                  55                  60


Arg Ala Ala Ala Ser Ala Ala Leu Glu Leu Pro Leu Gly Pro Ala Pro 
65                  70                  75                  80


Val Ser Val Ala Pro Gln Ala Glu Ala Glu Ala Arg Ser Thr Pro Gly 
                85                  90                  95


Pro Ala Gly Ser Arg Leu Gly Pro Glu Thr Phe Arg Gln Arg Phe Arg 
            100                 105                 110


Gln Phe Arg Tyr Gln Asp Ala Ala Gly Pro Arg Glu Ala Phe Arg Gln 
        115                 120                 125


Leu Arg Glu Leu Ser Arg Gln Trp Leu Arg Pro Asp Ile Arg Thr Lys 
    130                 135                 140


Glu Gln Ile Val Glu Met Leu Val Gln Glu Gln Leu Leu Ala Ile Leu 
145                 150                 155                 160


Pro Glu Ala Ala Arg Ala Arg Arg Ile Arg Arg Arg Thr Asp Val Arg 
                165                 170                 175


Ile Thr Gly 



<210>  1256
<211>  840
<212>  DNA
<213>  Homo sapiens

<400>  1256
ggacgcagag aagccagaga ctttcgcttc cggctgccgc aggcgcttcg ctggtgcaga     60

cgcagtgctg agcacacagc taccggacaa agagtgacgc ccggagctgg agttatggcg    120

gctacggagc cgatcttggc ggccactggg agtcccgcgg cggtgccacc ggagaaactg    180

gaaggagccg gttcgagctc agcccctgag cgtaactgtg tgggctcctc gctgccagag    240

gcctcaccgc ctgcccctga gccttccagt cccaacgccg cggtccctga agccatccct    300

acgccccgag ctgcggcctc cgcggccctg gagctgcctc tcgggcccgc acccgtgagc    360

gtagcgcctc aggccgaagc tgaagcgcgc tccacaccag gccccgccgg ctctagactc    420

ggtcccgaga cgttccgcca gcgtttccgg cagttccgct accaggatgc ggcgggtccc    480

cgggaggctt tccggcagct gcgggagctg tcccgccagt ggctgcggcc tgacatccgc    540

accaaggagc agatcgtgga gatgctggtg caagagcagc tgctcgccat cctgcccgag    600

gcggctcggg cccggcggat ccgccgccgc acggatgtgc gcatcactgg ctgagcggtg    660

gagctgcggg cggccagggc cgggcgctct gtgcggactg gggccatgat cgggcccggg    720

ggcctgagcc tgggacccca ccccgtgtta atgaaaaatg agttttggca gcgccaaaaa    780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    840


<210>  1257
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  1257

Met Ala Ala Thr Glu Pro Ile Leu Ala Ala Thr Gly Ser Pro Ala Ala 
1               5                   10                  15


Val Pro Pro Glu Lys Leu Glu Gly Ala Gly Ser Ser Ser Ala Pro Glu 
            20                  25                  30


Arg Asn Cys Val Gly Ser Ser Leu Pro Glu Ala Ser Pro Pro Ala Pro 
        35                  40                  45


Glu Pro Ser Ser Pro Asn Ala Ala Val Pro Glu Ala Ile Pro Thr Pro 
    50                  55                  60


Arg Ala Ala Ala Ser Ala Ala Leu Glu Leu Pro Leu Gly Pro Ala Pro 
65                  70                  75                  80


Val Ser Val Ala Pro Gln Ala Glu Ala Glu Ala Arg Ser Thr Pro Gly 
                85                  90                  95


Pro Ala Gly Ser Arg Leu Gly Pro Glu Thr Phe Arg Gln Arg Phe Arg 
            100                 105                 110


Gln Phe Arg Tyr Gln Asp Ala Ala Gly Pro Arg Glu Ala Phe Arg Gln 
        115                 120                 125


Leu Arg Glu Leu Ser Arg Gln Trp Leu Arg Pro Asp Ile Arg Thr Lys 
    130                 135                 140


Glu Gln Ile Val Glu Met Leu Val Gln Glu Gln Leu Leu Ala Ile Leu 
145                 150                 155                 160


Pro Glu Ala Ala Arg Ala Arg Arg Ile Arg Arg Arg Thr Asp Val Arg 
                165                 170                 175


Ile Thr Gly 



<210>  1258
<211>  1927
<212>  DNA
<213>  Homo sapiens

<400>  1258
agctgatggt atggtaggag gagtggagtg gagctcttgc cttgttactg aggaaatcta     60

tttgtttcta gtattactgg atttttgggg aaaaatttgt agtcctcccc ttgaaaggca    120

aaggggctag ttgtgccatt tgcctgcaca ggaaccatga ggagacatat ggtaacttat    180

gcctggcagc tcctgaagaa ggaactggga ctgtaccagc tcgccatgga tatcatcata    240

atgatccgag tgtgtaaaat gttccgccaa ggcctcaggg gattccggga atatcaaatc    300

attgagactg ctcactggaa gcaccctatc ttctccttct gggataaaaa gatgcaaagc    360

cgagtcacat ttgataccat ggacttcatt gcagaggagg gtcactttcc tccaaaggcc    420

attcagatca tgcagaagaa gccttcctgg agaacagagg atgagatcca ggccgtctgt    480

aacatcttgc aggttctgga tagctatcgg aactacgcag agcccctgca gctgctcctg    540

gccaaagtca tgcgctttga acggtttggt cgcaggcgtg tgatcatcaa gaaggggcag    600

aagggcaaca gcttttattt catctacctg ggcacagttg caataaccaa ggacgaggat    660

ggcagcagtg ccttcctaga tccccacccg aaattgctgc acaagggtag ctgttttggg    720

gaaatggacg ttctgcatgc ttcagtgagg aggtccacca tcgtctgtat ggaagaaacg    780

gagttcctgg ttgttgaccg ggaggacttc tttgctaata agctggacca ggaagttcag    840

aaggatgctc agtatcggtt tgaatttttt aggaagatgg agctgtttgc atcatggtct    900

gatgagaagc tctggcagct ggtagccatg gcgaagatag agaggttctc gtatgggcag    960

ctgatctcaa aagattttgg agagtcaccc ttcatcatgt ttatcagcaa gggcagctgt   1020

gaagtcctgc ggctgttgga ccttggggcc tccccttcct accgtagatg gatctggcag   1080

cacctggagc tgatagatgg cagacctctg aagacccacc tgagtgaata ctctcctatg   1140

gaaagattta aggaattcca gatcaaatca tatcctctgc aagactttag ctccttgaaa   1200

cttccacatc tcaaaaaagc ctgggggcta caggggacaa gcttcagcag gaagatcaga   1260

acctcaggag acactctctc caagatgctg ggcccgaaga tccaatccag gcctgctcag   1320

tcgatcaaat gtgccatgat caatatcaag cctggtgagc tccccaagga ggctgcagtg   1380

ggggcctacg tgaaggtgca cactgtggag cagggagaaa ttttggcctt ccttccagag   1440

ggtgaatgcg acacacgacc cttgatcctg atgagcctgg gaaatgagtt gatacggata   1500

aggaaggaaa tattttatga actgattgac aatgatgacg agatgataaa aaagttgtta   1560

aagctcaata ttgcattccc cagtgatgaa gatatgtgcc agaagttcct ccagcagaac   1620

agctggaata tctttcggaa ggacctgttg cagctgctcg tggagccttg ccaaagtcaa   1680

ctgttcactc caaaccggcc caagaagaga gagatctaca accctaagtc tgtggtcctg   1740

gatttgtgca gcatcaacaa gacgactaag cctcgttatc ctatttttat ggcaccccag   1800

aaatacctcc ccccattgag gattgtccaa gccatcaaag cacctcggta caaaatccga   1860

gaactcttgg cttagtgtaa gagcacaggg gtccttattt aggacaaata aaggatggtg   1920

gattggg                                                             1927


<210>  1259
<211>  572
<212>  PRT
<213>  Homo sapiens

<400>  1259

Met Arg Arg His Met Val Thr Tyr Ala Trp Gln Leu Leu Lys Lys Glu 
1               5                   10                  15


Leu Gly Leu Tyr Gln Leu Ala Met Asp Ile Ile Ile Met Ile Arg Val 
            20                  25                  30


Cys Lys Met Phe Arg Gln Gly Leu Arg Gly Phe Arg Glu Tyr Gln Ile 
        35                  40                  45


Ile Glu Thr Ala His Trp Lys His Pro Ile Phe Ser Phe Trp Asp Lys 
    50                  55                  60


Lys Met Gln Ser Arg Val Thr Phe Asp Thr Met Asp Phe Ile Ala Glu 
65                  70                  75                  80


Glu Gly His Phe Pro Pro Lys Ala Ile Gln Ile Met Gln Lys Lys Pro 
                85                  90                  95


Ser Trp Arg Thr Glu Asp Glu Ile Gln Ala Val Cys Asn Ile Leu Gln 
            100                 105                 110


Val Leu Asp Ser Tyr Arg Asn Tyr Ala Glu Pro Leu Gln Leu Leu Leu 
        115                 120                 125


Ala Lys Val Met Arg Phe Glu Arg Phe Gly Arg Arg Arg Val Ile Ile 
    130                 135                 140


Lys Lys Gly Gln Lys Gly Asn Ser Phe Tyr Phe Ile Tyr Leu Gly Thr 
145                 150                 155                 160


Val Ala Ile Thr Lys Asp Glu Asp Gly Ser Ser Ala Phe Leu Asp Pro 
                165                 170                 175


His Pro Lys Leu Leu His Lys Gly Ser Cys Phe Gly Glu Met Asp Val 
            180                 185                 190


Leu His Ala Ser Val Arg Arg Ser Thr Ile Val Cys Met Glu Glu Thr 
        195                 200                 205


Glu Phe Leu Val Val Asp Arg Glu Asp Phe Phe Ala Asn Lys Leu Asp 
    210                 215                 220


Gln Glu Val Gln Lys Asp Ala Gln Tyr Arg Phe Glu Phe Phe Arg Lys 
225                 230                 235                 240


Met Glu Leu Phe Ala Ser Trp Ser Asp Glu Lys Leu Trp Gln Leu Val 
                245                 250                 255


Ala Met Ala Lys Ile Glu Arg Phe Ser Tyr Gly Gln Leu Ile Ser Lys 
            260                 265                 270


Asp Phe Gly Glu Ser Pro Phe Ile Met Phe Ile Ser Lys Gly Ser Cys 
        275                 280                 285


Glu Val Leu Arg Leu Leu Asp Leu Gly Ala Ser Pro Ser Tyr Arg Arg 
    290                 295                 300


Trp Ile Trp Gln His Leu Glu Leu Ile Asp Gly Arg Pro Leu Lys Thr 
305                 310                 315                 320


His Leu Ser Glu Tyr Ser Pro Met Glu Arg Phe Lys Glu Phe Gln Ile 
                325                 330                 335


Lys Ser Tyr Pro Leu Gln Asp Phe Ser Ser Leu Lys Leu Pro His Leu 
            340                 345                 350


Lys Lys Ala Trp Gly Leu Gln Gly Thr Ser Phe Ser Arg Lys Ile Arg 
        355                 360                 365


Thr Ser Gly Asp Thr Leu Ser Lys Met Leu Gly Pro Lys Ile Gln Ser 
    370                 375                 380


Arg Pro Ala Gln Ser Ile Lys Cys Ala Met Ile Asn Ile Lys Pro Gly 
385                 390                 395                 400


Glu Leu Pro Lys Glu Ala Ala Val Gly Ala Tyr Val Lys Val His Thr 
                405                 410                 415


Val Glu Gln Gly Glu Ile Leu Ala Phe Leu Pro Glu Gly Glu Cys Asp 
            420                 425                 430


Thr Arg Pro Leu Ile Leu Met Ser Leu Gly Asn Glu Leu Ile Arg Ile 
        435                 440                 445


Arg Lys Glu Ile Phe Tyr Glu Leu Ile Asp Asn Asp Asp Glu Met Ile 
    450                 455                 460


Lys Lys Leu Leu Lys Leu Asn Ile Ala Phe Pro Ser Asp Glu Asp Met 
465                 470                 475                 480


Cys Gln Lys Phe Leu Gln Gln Asn Ser Trp Asn Ile Phe Arg Lys Asp 
                485                 490                 495


Leu Leu Gln Leu Leu Val Glu Pro Cys Gln Ser Gln Leu Phe Thr Pro 
            500                 505                 510


Asn Arg Pro Lys Lys Arg Glu Ile Tyr Asn Pro Lys Ser Val Val Leu 
        515                 520                 525


Asp Leu Cys Ser Ile Asn Lys Thr Thr Lys Pro Arg Tyr Pro Ile Phe 
    530                 535                 540


Met Ala Pro Gln Lys Tyr Leu Pro Pro Leu Arg Ile Val Gln Ala Ile 
545                 550                 555                 560


Lys Ala Pro Arg Tyr Lys Ile Arg Glu Leu Leu Ala 
                565                 570


<210>  1260
<211>  6276
<212>  DNA
<213>  Homo sapiens

<400>  1260
agtcggcatc catcagcggg cgggggtgtc gccgaacagg ctgctccgca gagcccgccg     60

cgaccccgcg ccgccccgcc ccgcggcctg cctgccagag gagccgaggg ggccgcccct    120

cgcccaacct gcccgacatg gggaaccccg ggcccaggcg tgctggtcac catgacaaca    180

gagacaggcc ccgactctga ggtgaagaaa gctcaggagg aggccccgca gcagcccgag    240

gctgctgccg ctgtgaccac ccctgtgacc cctgcaggcc acggccaccc agaggccaac    300

tccaatgaga agcatccatc ccagcaggac acgcggcctg ctgaacagag cctagacatg    360

gaggagaagg actacagtga ggccgatggc ctttcggaga ggaccacgcc cagcaaggcc    420

cagaaatcgc cccagaagat tgccaagaaa tacaagagtg ccatctgccg ggtcactctg    480

cttgatgcct cggagtatga gtgtgaggtg gagaaacatg gccggggcca ggtgctgttt    540

gacctggtct gtgaacacct caacctccta gagaaggact acttcggcct gaccttctgt    600

gatgctgaca gccagaagaa ctggctggac ccctccaagg agatcaagaa gcagatccgg    660

agtagcccct ggaattttgc cttcacagtc aagttctacc cgcctgatcc tgcccagctg    720

acagaagaca tcacaagata ctacctgtgc ctgcagctgc gggcagacat catcacgggc    780

cggctgccat gctcctttgt cacgcatgcc ctactgggct cctacgctgt gcaggctgag    840

ctgggtgact atgatgctga ggagcatgtg ggcaactatg tcagcgagct ccgcttcgcc    900

cctaaccaga cccgggagct ggaggagagg atcatggagc tgcataagac atataggggg    960

atgaccccgg gagaagcaga aatccacttc ttagagaatg ccaagaagct ttccatgtac   1020

ggagtagacc tgcaccatgc caaggactct gagggcatcg acatcatgtt aggcgtttgt   1080

gccaatggcc tgctcatcta ccgggaccgg ctgagaatca accgctttgc ctggcccaag   1140

atcctcaaga tctcctacaa gaggagtaac ttctatatca agatccggcc tggggagtat   1200

gagcaatttg agagcacaat tggctttaag ctcccaaacc accggtcagc caagagactg   1260

tggaaggtct gcatcgagca tcatacattc ttccggctgg tgtcccctga gcccccaccc   1320

aagggcttcc tggtgatggg ctccaagttc cggtacagtg ggaggaccca ggcacagact   1380

cgccaggcca gcgccctcat tgaccggcct gcacccttct ttgagcgttc ttccagcaaa   1440

cggtacacca tgtcccgcag ccttgatgga gcagagttct cccgcccagc ctcggtcagc   1500

gagaaccatg atgcagggcc tgacggtgac aagcgggatg aggatggcga gtctgggggg   1560

caacggtcag aggctgagga gggagaggtc aggactccaa ccaagatcaa ggagctaaag   1620

ccggagcagg aaaccacgcc gagacacaag caggagttct tagacaagcc agaagatgtc   1680

ttgctgaagc accaggccag catcaatgag ctcaaaagga ccctgaagga gcccaacagc   1740

aaactcatcc accgggatcg agactgggaa cgggagcgca ggctgccctc ctcccccgcc   1800

tccccctccc ccaagggcac ccctgagaaa gccaatgaga gagcagggct gagggagggc   1860

tccgaggaga aagtcaaacc accacgtccc cgggccccag agagtgacac aggcgatgag   1920

gaccaggacc aggagaggga cacggtgttc ctgaaggaca accacctggc cattgagcgc   1980

aagtgctcca gcatcacggt cagctctacg tctagcctgg aggctgaggt ggacttcacg   2040

gtcattggtg actaccatgg cagcgccttc gaagacttct cccgcagcct gcctgagctc   2100

gaccgggaca aaagcgactc ggacactgag ggcctgctgt tctcccggga tctcaacaag   2160

ggggccccca gccaggatga tgagtctggg ggcattgagg acagcccgga tcgaggggcc   2220

tgctccaccc cggatatgcc ccagtttgag cccgtgaaaa cagaaaccat gactgtcagc   2280

agtctggcca ttagaaagaa gattgagccg gaggccgtac tgcagaccag agtctccgct   2340

atggataaca cccagcaggt tgatgggagt gcctcagtgg ggagggagtt catagcaacc   2400

actccctcca tcaccacgga gaccatatcg accaccatgg agaacagtct caagtccggg   2460

aagggggcag ctgccatgat cccaggccca cagacggtgg ccacggaaat ccgttctctt   2520

tctccgatca tcgggaaaga tgtcctcacc agcacctacg gcgccactgc ggaaaccctc   2580

tcaacctcca ccaccaccca tgtcaccaaa actgtgaaag gagggttttc tgagacaagg   2640

atcgagaagc gaatcatcat tactggggat gaagatgtcg atcaagacca ggccctggct   2700

ttggccatca aggaggccaa actgcagcat cctgatatgc tggtaaccaa agctgtcgta   2760

tacagagaaa cagacccatc cccagaggag agggacaaga agccacagga atcctgacct   2820

ctgtgaagag atcctggcat ttctggtcca acccaagcca gagaaccatt aagaaggggc   2880

cttcattctg gattctccga cgcaacactg acgtcccagc tgcgacgtac tgtcactgat   2940

gagagactgg gaagggaaaa gcatatatat atagatatat agagatatag atatatatac   3000

aggaaacacc gcatccttgc actgctgctg gggctggcag agcagttggc tgacagcaac   3060

aaccgacatc tgaacaccta catttccttt gcagacaaat tgaagaactg gtgggatttt   3120

tttcaagaaa aaaaattata taataactat aatcccttgc tcaccccttt cccccgccaa   3180

ataagaaacg caagccagac cacgatgatt gtagaagtcc ctcccgccct ggttctgcac   3240

gttacagtta gcagacgagc aattccattt gttcttctcc agcatctcta aggcccactt   3300

gaatgcaaag gaaaacactt gcacagcaaa gcaagagaag tcacagcagc aagacacgca   3360

cagtcaacca ttttccgaga aaaaaagaaa attccccact tggaaagaaa gaggaggaac   3420

actggattct tactttctgg atcttgacac tgggctgcaa aacctacctt cctctctccc   3480

gcctcccctc accctcaact ctcaatgtct tgctgtcatt ttctgtctcg gctccctcct   3540

cccccttccc ccttccccca ccccacaccc ttcaccctct gtgtcctggt ccttctgagg   3600

gccactgcag atgactctcc tttgaaatga gaaaaagaaa agaaagcaag aacagaaaac   3660

gaagccacag gaagggaagt agacattgta tgcttatggt ttctcattat gaaggtgcag   3720

cttgtaggag gtttgtacgg atgtgctttg aagttatgta tattacatat aacaggaaaa   3780

aatattaaaa taaacagtgc tggtaagtat gaagctgaca ttctaaaatt ataattatct   3840

gactgtgatt gatgtatcct gaggttccta gatctcactg aactggccca gctaaggaga   3900

cctggactct gggtgtgggt tggctcacag taggggctga cgggttcagt gtagtaatac   3960

tgtgtgtggt gtttgtaatt ggttgattgg tggggagggg tggggggccc taatggagag   4020

gtgtgggttt ggcaagaaag aagcaacaca gatgtcgtcc ccaaaatgcc agttcaagac   4080

accttctccc tgcccccctg gtagtaacag tcagggcctg gtctgtgctc aggtactggg   4140

tcccagtctg ggactctgct gctgaagttg ccacagtaga ggtccctggc ttagtcctta   4200

tctccctacg gggcttgcct tggttttcag tcttctctct ctttctctct tttttttttt   4260

tttgccacat tctgcccttc cctgacccca ttgtaataac caactccata tccaaaggga   4320

ggtggtgctc tcagccattg tagaagatgg tggctttaac ctgactgtct aaaaattccc   4380

agctaagcct tttcctctac tctcttcctt gttctgaatc atttcttctt ctcaggccaa   4440

agtagccatg gtaaggaggc ttcatggggc agaccctgaa agatcaaaac tgcatttgca   4500

aagccctccc ctgtcccagg acaaagctga gactgacggg tgatgttgct cataggctcc   4560

agctctgcat aagaccttgg cttggagacc tccctctcag tcaacagctg aactctgagc   4620

ttgtgcccag aaattacccc aagaccacag gaacccttca agaagctccc atcacaagct   4680

tggcattgct ctctgccaca cgtgggcttc ctcaggcttg tctgccacaa gctacttctc   4740

tgagctcaga aagtgcccct tgatgaggga aaatgtccca ctgcactgcg aatttctcag   4800

ttccatttta cctcccagtc ctccttctaa accagttaat aaattcattc cacaagtatt   4860

tactgattac ctgcttgtgc cagggactat tctcaggctg aagaaggtgg gaggggaggg   4920

cggaacctga ggagccacct gagccagctt tatatttcaa ccatggctgg cccatctgag   4980

agcatctccc cactctcgcc aacctatcgg ggcatagccc agggatgccc ccaggcggcc   5040

caggttagat gcgtcccttt ggcttgtcag tgatgacata caccttagct gcttagctgg   5100

tgctggcctg aggcagggca ggaaatcaga atagcatttg cttctctggg caaatgggaa   5160

gttcagcggg gcagcagaat cagtggcatt ccccctggtg caggccggtg ggtccactcc   5220

aactccccct gagtgtagca gcacactttc catacaccag gttctttcta caatcctggt   5280

ggaaaagcca cagaaccttc ttcctgccct tcttgagagt tccccctctt tctgggtcaa   5340

gagctggagt ggtggctcca tcctctctgg gccacttcgg tctaggaact catctttgca   5400

ggaaccagga gtcctgagca cactgaacac acctcagagg gaggatcctt gttgtggatt   5460

ttgcacctgg ctttggggca ggggtgaagt gaccaggctt agcttgtgga gtttatgggc   5520

caccagggtt tggggaaatc accatcccgc ggatgctgtg acctcccttc tacggagatg   5580

caggcagtgc cacgagggag gaggggacct gcaaagctag aatctagggc actgtttcct   5640

ccccatcctt ctctttgtag agaatagaga cgtttgtctt gtctgtcttc aacctacttt   5700

tccttttctc ttttttgttt ctcatcctct ctgtgccacc tctccaccca ggaggccatg   5760

tagcatagtg gaaaaagtcc ctgagggcgg ttaggagttc tgggtgacca tcctggctca   5820

gctcctaact caccatgtga catcaggcta tccccattcc ccctcttggg cctcagtttc   5880

ccgacttgca aaataagcag aaagaaccag atgctctcca gggtcttttt ctactttgct   5940

atctcatggg tcttcatttt ctcttatttt gttttctctg gatcttttcc atctgagggt   6000

acaggaagta ccaggacctg tttcagtttt tgaatcctgc aagcacattc caagactggc   6060

ctgaaactgc atgagcaaca tcactcgaaa taattttttt tttcaaaagc accttaacaa   6120

ccaattgcga tgctgtcctg ttccttttta ctcacaccct tctctccttt ctcgtcccca   6180

tgctccccca cctcagtgct ccgtgctgta tgcgtgtgct ctctgttctt gtatactcaa   6240

tataagtgaa ataaatgtgt ttgatgctga accata                             6276


<210>  1261
<211>  881
<212>  PRT
<213>  Homo sapiens

<400>  1261

Met Thr Thr Glu Thr Gly Pro Asp Ser Glu Val Lys Lys Ala Gln Glu 
1               5                   10                  15


Glu Ala Pro Gln Gln Pro Glu Ala Ala Ala Ala Val Thr Thr Pro Val 
            20                  25                  30


Thr Pro Ala Gly His Gly His Pro Glu Ala Asn Ser Asn Glu Lys His 
        35                  40                  45


Pro Ser Gln Gln Asp Thr Arg Pro Ala Glu Gln Ser Leu Asp Met Glu 
    50                  55                  60


Glu Lys Asp Tyr Ser Glu Ala Asp Gly Leu Ser Glu Arg Thr Thr Pro 
65                  70                  75                  80


Ser Lys Ala Gln Lys Ser Pro Gln Lys Ile Ala Lys Lys Tyr Lys Ser 
                85                  90                  95


Ala Ile Cys Arg Val Thr Leu Leu Asp Ala Ser Glu Tyr Glu Cys Glu 
            100                 105                 110


Val Glu Lys His Gly Arg Gly Gln Val Leu Phe Asp Leu Val Cys Glu 
        115                 120                 125


His Leu Asn Leu Leu Glu Lys Asp Tyr Phe Gly Leu Thr Phe Cys Asp 
    130                 135                 140


Ala Asp Ser Gln Lys Asn Trp Leu Asp Pro Ser Lys Glu Ile Lys Lys 
145                 150                 155                 160


Gln Ile Arg Ser Ser Pro Trp Asn Phe Ala Phe Thr Val Lys Phe Tyr 
                165                 170                 175


Pro Pro Asp Pro Ala Gln Leu Thr Glu Asp Ile Thr Arg Tyr Tyr Leu 
            180                 185                 190


Cys Leu Gln Leu Arg Ala Asp Ile Ile Thr Gly Arg Leu Pro Cys Ser 
        195                 200                 205


Phe Val Thr His Ala Leu Leu Gly Ser Tyr Ala Val Gln Ala Glu Leu 
    210                 215                 220


Gly Asp Tyr Asp Ala Glu Glu His Val Gly Asn Tyr Val Ser Glu Leu 
225                 230                 235                 240


Arg Phe Ala Pro Asn Gln Thr Arg Glu Leu Glu Glu Arg Ile Met Glu 
                245                 250                 255


Leu His Lys Thr Tyr Arg Gly Met Thr Pro Gly Glu Ala Glu Ile His 
            260                 265                 270


Phe Leu Glu Asn Ala Lys Lys Leu Ser Met Tyr Gly Val Asp Leu His 
        275                 280                 285


His Ala Lys Asp Ser Glu Gly Ile Asp Ile Met Leu Gly Val Cys Ala 
    290                 295                 300


Asn Gly Leu Leu Ile Tyr Arg Asp Arg Leu Arg Ile Asn Arg Phe Ala 
305                 310                 315                 320


Trp Pro Lys Ile Leu Lys Ile Ser Tyr Lys Arg Ser Asn Phe Tyr Ile 
                325                 330                 335


Lys Ile Arg Pro Gly Glu Tyr Glu Gln Phe Glu Ser Thr Ile Gly Phe 
            340                 345                 350


Lys Leu Pro Asn His Arg Ser Ala Lys Arg Leu Trp Lys Val Cys Ile 
        355                 360                 365


Glu His His Thr Phe Phe Arg Leu Val Ser Pro Glu Pro Pro Pro Lys 
    370                 375                 380


Gly Phe Leu Val Met Gly Ser Lys Phe Arg Tyr Ser Gly Arg Thr Gln 
385                 390                 395                 400


Ala Gln Thr Arg Gln Ala Ser Ala Leu Ile Asp Arg Pro Ala Pro Phe 
                405                 410                 415


Phe Glu Arg Ser Ser Ser Lys Arg Tyr Thr Met Ser Arg Ser Leu Asp 
            420                 425                 430


Gly Ala Glu Phe Ser Arg Pro Ala Ser Val Ser Glu Asn His Asp Ala 
        435                 440                 445


Gly Pro Asp Gly Asp Lys Arg Asp Glu Asp Gly Glu Ser Gly Gly Gln 
    450                 455                 460


Arg Ser Glu Ala Glu Glu Gly Glu Val Arg Thr Pro Thr Lys Ile Lys 
465                 470                 475                 480


Glu Leu Lys Pro Glu Gln Glu Thr Thr Pro Arg His Lys Gln Glu Phe 
                485                 490                 495


Leu Asp Lys Pro Glu Asp Val Leu Leu Lys His Gln Ala Ser Ile Asn 
            500                 505                 510


Glu Leu Lys Arg Thr Leu Lys Glu Pro Asn Ser Lys Leu Ile His Arg 
        515                 520                 525


Asp Arg Asp Trp Glu Arg Glu Arg Arg Leu Pro Ser Ser Pro Ala Ser 
    530                 535                 540


Pro Ser Pro Lys Gly Thr Pro Glu Lys Ala Asn Glu Arg Ala Gly Leu 
545                 550                 555                 560


Arg Glu Gly Ser Glu Glu Lys Val Lys Pro Pro Arg Pro Arg Ala Pro 
                565                 570                 575


Glu Ser Asp Thr Gly Asp Glu Asp Gln Asp Gln Glu Arg Asp Thr Val 
            580                 585                 590


Phe Leu Lys Asp Asn His Leu Ala Ile Glu Arg Lys Cys Ser Ser Ile 
        595                 600                 605


Thr Val Ser Ser Thr Ser Ser Leu Glu Ala Glu Val Asp Phe Thr Val 
    610                 615                 620


Ile Gly Asp Tyr His Gly Ser Ala Phe Glu Asp Phe Ser Arg Ser Leu 
625                 630                 635                 640


Pro Glu Leu Asp Arg Asp Lys Ser Asp Ser Asp Thr Glu Gly Leu Leu 
                645                 650                 655


Phe Ser Arg Asp Leu Asn Lys Gly Ala Pro Ser Gln Asp Asp Glu Ser 
            660                 665                 670


Gly Gly Ile Glu Asp Ser Pro Asp Arg Gly Ala Cys Ser Thr Pro Asp 
        675                 680                 685


Met Pro Gln Phe Glu Pro Val Lys Thr Glu Thr Met Thr Val Ser Ser 
    690                 695                 700


Leu Ala Ile Arg Lys Lys Ile Glu Pro Glu Ala Val Leu Gln Thr Arg 
705                 710                 715                 720


Val Ser Ala Met Asp Asn Thr Gln Gln Val Asp Gly Ser Ala Ser Val 
                725                 730                 735


Gly Arg Glu Phe Ile Ala Thr Thr Pro Ser Ile Thr Thr Glu Thr Ile 
            740                 745                 750


Ser Thr Thr Met Glu Asn Ser Leu Lys Ser Gly Lys Gly Ala Ala Ala 
        755                 760                 765


Met Ile Pro Gly Pro Gln Thr Val Ala Thr Glu Ile Arg Ser Leu Ser 
    770                 775                 780


Pro Ile Ile Gly Lys Asp Val Leu Thr Ser Thr Tyr Gly Ala Thr Ala 
785                 790                 795                 800


Glu Thr Leu Ser Thr Ser Thr Thr Thr His Val Thr Lys Thr Val Lys 
                805                 810                 815


Gly Gly Phe Ser Glu Thr Arg Ile Glu Lys Arg Ile Ile Ile Thr Gly 
            820                 825                 830


Asp Glu Asp Val Asp Gln Asp Gln Ala Leu Ala Leu Ala Ile Lys Glu 
        835                 840                 845


Ala Lys Leu Gln His Pro Asp Met Leu Val Thr Lys Ala Val Val Tyr 
    850                 855                 860


Arg Glu Thr Asp Pro Ser Pro Glu Glu Arg Asp Lys Lys Pro Gln Glu 
865                 870                 875                 880


Ser 



<210>  1262
<211>  5863
<212>  DNA
<213>  Homo sapiens

<400>  1262
gtgcctgact gacagaagtt cttgcccccg gggagctggt gtggacagag gagggagcct     60

agacatggag gagaaggact acagtgaggc cgatggcctt tcggagagga ccacgcccag    120

caaggcccag aaatcgcccc agaagattgc caagaaatac aagagtgcca tctgccgggt    180

cactctgctt gatgcctcgg agtatgagtg tgaggtggag aaacatggcc ggggccaggt    240

gctgtttgac ctggtctgtg aacacctcaa cctcctagag aaggactact tcggcctgac    300

cttctgtgat gctgacagcc agaagaactg gctggacccc tccaaggaga tcaagaagca    360

gatccggagt agcccctgga attttgcctt cacagtcaag ttctacccgc ctgatcctgc    420

ccagctgaca gaagacatca caagatacta cctgtgcctg cagctgcggg cagacatcat    480

cacgggccgg ctgccatgct cctttgtcac gcatgcccta ctgggctcct acgctgtgca    540

ggctgagctg ggtgactatg atgctgagga gcatgtgggc aactatgtca gcgagctccg    600

cttcgcccct aaccagaccc gggagctgga ggagaggatc atggagctgc ataagacata    660

tagggggatg accccgggag aagcagaaat ccacttctta gagaatgcca agaagctttc    720

catgtacgga gtagacctgc accatgccaa ggactctgag ggcatcgaca tcatgttagg    780

cgtttgtgcc aatggcctgc tcatctaccg ggaccggctg agaatcaacc gctttgcctg    840

gcccaagatc ctcaagatct cctacaagag gagtaacttc tatatcaaga tccggcctgg    900

ggagtatgag caatttgaga gcacaattgg ctttaagctc ccaaaccacc ggtcagccaa    960

gagactgtgg aaggtctgca tcgagcatca tacattcttc cggctggtgt cccctgagcc   1020

cccacccaag ggcttcctgg tgatgggctc caagttccgg tacagtggga ggacccaggc   1080

acagactcgc caggccagcg ccctcattga ccggcctgca cccttctttg agcgttcttc   1140

cagcaaacgg tacaccatgt cccgcagcct tgatggagca gagttctccc gcccagcctc   1200

ggtcagcgag aaccatgatg cagggcctga cggtgacaag cgggatgagg atggcgagtc   1260

tggggggcaa cggtcagagg ctgaggaggg agaggtcagg actccaacca agatcaagga   1320

gctaaagttc ttagacaagc cagaagatgt cttgctgaag caccaggcca gcatcaatga   1380

gctcaaaagg accctgaagg agcccaacag caaactcatc caccgggatc gagactggga   1440

acgggagcgc aggctgccct cctcccccgc ctccccctcc cccaagggca cccctgagaa   1500

agccaatgag agagcagggc tgagggaggg ctccgaggag aaagtcaaac caccacgtcc   1560

ccgggcccca gagagtgaca caggcgatga ggaccaggac caggagaggg acacggtgtt   1620

cctgaaggac aaccacctgg ccattgagcg caagtgctcc agcatcacgg tcagctctac   1680

gtctagcctg gaggctgagg tggacttcac ggtcattggt gactaccatg gcagcgcctt   1740

cgaagacttc tcccgcagcc tgcctgagct cgaccgggac aaaagcgact cggacactga   1800

gggcctgctg ttctcccggg atctcaacaa gggggccccc agccaggatg atgagtctgg   1860

gggcattgag gacagcccgg atcgaggggc ctgctccacc ccggatatgc cccagtttga   1920

gcccgtgaaa acagaaacca tgactgtcag cagtctggcc attagaaaga agattgagcc   1980

ggaggccgta ctgcagacca gagtctccgc tatggataac acccaggaga acagtctcaa   2040

gtccgggaag ggggcagctg ccatgatccc aggcccacag acggtggcca cggaaatccg   2100

ttctctttct ccgatcatcg ggaaagatgt cctcaccagc acctacggcg ccactgcgga   2160

aaccctctca acctccacca ccacccatgt caccaaaact gtgaaaggag ggttttctga   2220

gacaaggatc gagaagcgaa tcatcattac tggggatgaa gatgtcgatc aagaccaggc   2280

cctggctttg gccatcaagg aggccaaact gcagcatcct gatatgctgg taaccaaagc   2340

tgtcgtatac agagaaacag acccatcccc agaggagagg gacaagaagc cacaggaatc   2400

ctgacctctg tgaagagatc ctggcatttc tggtccaacc caagccagag aaccattaag   2460

aaggggcctt cattctggat tctccgacgc aacactgacg tcccagctgc gacgtactgt   2520

cactgatgag agactgggaa gggaaaagca tatatatata gatatataga gatatagata   2580

tatatacagg aaacaccgca tccttgcact gctgctgggg ctggcagagc agttggctga   2640

cagcaacaac cgacatctga acacctacat ttcctttgca gacaaattga agaactggtg   2700

ggattttttt caagaaaaaa aattatataa taactataat cccttgctca cccctttccc   2760

ccgccaaata agaaacgcaa gccagaccac gatgattgta gaagtccctc ccgccctggt   2820

tctgcacgtt acagttagca gacgagcaat tccatttgtt cttctccagc atctctaagg   2880

cccacttgaa tgcaaaggaa aacacttgca cagcaaagca agagaagtca cagcagcaag   2940

acacgcacag tcaaccattt tccgagaaaa aaagaaaatt ccccacttgg aaagaaagag   3000

gaggaacact ggattcttac tttctggatc ttgacactgg gctgcaaaac ctaccttcct   3060

ctctcccgcc tcccctcacc ctcaactctc aatgtcttgc tgtcattttc tgtctcggct   3120

ccctcctccc ccttccccct tcccccaccc cacacccttc accctctgtg tcctggtcct   3180

tctgagggcc actgcagatg actctccttt gaaatgagaa aaagaaaaga aagcaagaac   3240

agaaaacgaa gccacaggaa gggaagtaga cattgtatgc ttatggtttc tcattatgaa   3300

ggtgcagctt gtaggaggtt tgtacggatg tgctttgaag ttatgtatat tacatataac   3360

aggaaaaaat attaaaataa acagtgctgg taagtatgaa gctgacattc taaaattata   3420

attatctgac tgtgattgat gtatcctgag gttcctagat ctcactgaac tggcccagct   3480

aaggagacct ggactctggg tgtgggttgg ctcacagtag gggctgacgg gttcagtgta   3540

gtaatactgt gtgtggtgtt tgtaattggt tgattggtgg ggaggggtgg ggggccctaa   3600

tggagaggtg tgggtttggc aagaaagaag caacacagat gtcgtcccca aaatgccagt   3660

tcaagacacc ttctccctgc ccccctggta gtaacagtca gggcctggtc tgtgctcagg   3720

tactgggtcc cagtctggga ctctgctgct gaagttgcca cagtagaggt ccctggctta   3780

gtccttatct ccctacgggg cttgccttgg ttttcagtct tctctctctt tctctctttt   3840

tttttttttt gccacattct gcccttccct gaccccattg taataaccaa ctccatatcc   3900

aaagggaggt ggtgctctca gccattgtag aagatggtgg ctttaacctg actgtctaaa   3960

aattcccagc taagcctttt cctctactct cttccttgtt ctgaatcatt tcttcttctc   4020

aggccaaagt agccatggta aggaggcttc atggggcaga ccctgaaaga tcaaaactgc   4080

atttgcaaag ccctcccctg tcccaggaca aagctgagac tgacgggtga tgttgctcat   4140

aggctccagc tctgcataag accttggctt ggagacctcc ctctcagtca acagctgaac   4200

tctgagcttg tgcccagaaa ttaccccaag accacaggaa cccttcaaga agctcccatc   4260

acaagcttgg cattgctctc tgccacacgt gggcttcctc aggcttgtct gccacaagct   4320

acttctctga gctcagaaag tgccccttga tgagggaaaa tgtcccactg cactgcgaat   4380

ttctcagttc cattttacct cccagtcctc cttctaaacc agttaataaa ttcattccac   4440

aagtatttac tgattacctg cttgtgccag ggactattct caggctgaag aaggtgggag   4500

gggagggcgg aacctgagga gccacctgag ccagctttat atttcaacca tggctggccc   4560

atctgagagc atctccccac tctcgccaac ctatcggggc atagcccagg gatgccccca   4620

ggcggcccag gttagatgcg tccctttggc ttgtcagtga tgacatacac cttagctgct   4680

tagctggtgc tggcctgagg cagggcagga aatcagaata gcatttgctt ctctgggcaa   4740

atgggaagtt cagcggggca gcagaatcag tggcattccc cctggtgcag gccggtgggt   4800

ccactccaac tccccctgag tgtagcagca cactttccat acaccaggtt ctttctacaa   4860

tcctggtgga aaagccacag aaccttcttc ctgcccttct tgagagttcc ccctctttct   4920

gggtcaagag ctggagtggt ggctccatcc tctctgggcc acttcggtct aggaactcat   4980

ctttgcagga accaggagtc ctgagcacac tgaacacacc tcagagggag gatccttgtt   5040

gtggattttg cacctggctt tggggcaggg gtgaagtgac caggcttagc ttgtggagtt   5100

tatgggccac cagggtttgg ggaaatcacc atcccgcgga tgctgtgacc tcccttctac   5160

ggagatgcag gcagtgccac gagggaggag gggacctgca aagctagaat ctagggcact   5220

gtttcctccc catccttctc tttgtagaga atagagacgt ttgtcttgtc tgtcttcaac   5280

ctacttttcc ttttctcttt tttgtttctc atcctctctg tgccacctct ccacccagga   5340

ggccatgtag catagtggaa aaagtccctg agggcggtta ggagttctgg gtgaccatcc   5400

tggctcagct cctaactcac catgtgacat caggctatcc ccattccccc tcttgggcct   5460

cagtttcccg acttgcaaaa taagcagaaa gaaccagatg ctctccaggg tctttttcta   5520

ctttgctatc tcatgggtct tcattttctc ttattttgtt ttctctggat cttttccatc   5580

tgagggtaca ggaagtacca ggacctgttt cagtttttga atcctgcaag cacattccaa   5640

gactggcctg aaactgcatg agcaacatca ctcgaaataa tttttttttt caaaagcacc   5700

ttaacaacca attgcgatgc tgtcctgttc ctttttactc acacccttct ctcctttctc   5760

gtccccatgc tcccccacct cagtgctccg tgctgtatgc gtgtgctctc tgttcttgta   5820

tactcaatat aagtgaaata aatgtgtttg atgctgaacc ata                     5863


<210>  1263
<211>  779
<212>  PRT
<213>  Homo sapiens

<400>  1263

Met Glu Glu Lys Asp Tyr Ser Glu Ala Asp Gly Leu Ser Glu Arg Thr 
1               5                   10                  15


Thr Pro Ser Lys Ala Gln Lys Ser Pro Gln Lys Ile Ala Lys Lys Tyr 
            20                  25                  30


Lys Ser Ala Ile Cys Arg Val Thr Leu Leu Asp Ala Ser Glu Tyr Glu 
        35                  40                  45


Cys Glu Val Glu Lys His Gly Arg Gly Gln Val Leu Phe Asp Leu Val 
    50                  55                  60


Cys Glu His Leu Asn Leu Leu Glu Lys Asp Tyr Phe Gly Leu Thr Phe 
65                  70                  75                  80


Cys Asp Ala Asp Ser Gln Lys Asn Trp Leu Asp Pro Ser Lys Glu Ile 
                85                  90                  95


Lys Lys Gln Ile Arg Ser Ser Pro Trp Asn Phe Ala Phe Thr Val Lys 
            100                 105                 110


Phe Tyr Pro Pro Asp Pro Ala Gln Leu Thr Glu Asp Ile Thr Arg Tyr 
        115                 120                 125


Tyr Leu Cys Leu Gln Leu Arg Ala Asp Ile Ile Thr Gly Arg Leu Pro 
    130                 135                 140


Cys Ser Phe Val Thr His Ala Leu Leu Gly Ser Tyr Ala Val Gln Ala 
145                 150                 155                 160


Glu Leu Gly Asp Tyr Asp Ala Glu Glu His Val Gly Asn Tyr Val Ser 
                165                 170                 175


Glu Leu Arg Phe Ala Pro Asn Gln Thr Arg Glu Leu Glu Glu Arg Ile 
            180                 185                 190


Met Glu Leu His Lys Thr Tyr Arg Gly Met Thr Pro Gly Glu Ala Glu 
        195                 200                 205


Ile His Phe Leu Glu Asn Ala Lys Lys Leu Ser Met Tyr Gly Val Asp 
    210                 215                 220


Leu His His Ala Lys Asp Ser Glu Gly Ile Asp Ile Met Leu Gly Val 
225                 230                 235                 240


Cys Ala Asn Gly Leu Leu Ile Tyr Arg Asp Arg Leu Arg Ile Asn Arg 
                245                 250                 255


Phe Ala Trp Pro Lys Ile Leu Lys Ile Ser Tyr Lys Arg Ser Asn Phe 
            260                 265                 270


Tyr Ile Lys Ile Arg Pro Gly Glu Tyr Glu Gln Phe Glu Ser Thr Ile 
        275                 280                 285


Gly Phe Lys Leu Pro Asn His Arg Ser Ala Lys Arg Leu Trp Lys Val 
    290                 295                 300


Cys Ile Glu His His Thr Phe Phe Arg Leu Val Ser Pro Glu Pro Pro 
305                 310                 315                 320


Pro Lys Gly Phe Leu Val Met Gly Ser Lys Phe Arg Tyr Ser Gly Arg 
                325                 330                 335


Thr Gln Ala Gln Thr Arg Gln Ala Ser Ala Leu Ile Asp Arg Pro Ala 
            340                 345                 350


Pro Phe Phe Glu Arg Ser Ser Ser Lys Arg Tyr Thr Met Ser Arg Ser 
        355                 360                 365


Leu Asp Gly Ala Glu Phe Ser Arg Pro Ala Ser Val Ser Glu Asn His 
    370                 375                 380


Asp Ala Gly Pro Asp Gly Asp Lys Arg Asp Glu Asp Gly Glu Ser Gly 
385                 390                 395                 400


Gly Gln Arg Ser Glu Ala Glu Glu Gly Glu Val Arg Thr Pro Thr Lys 
                405                 410                 415


Ile Lys Glu Leu Lys Phe Leu Asp Lys Pro Glu Asp Val Leu Leu Lys 
            420                 425                 430


His Gln Ala Ser Ile Asn Glu Leu Lys Arg Thr Leu Lys Glu Pro Asn 
        435                 440                 445


Ser Lys Leu Ile His Arg Asp Arg Asp Trp Glu Arg Glu Arg Arg Leu 
    450                 455                 460


Pro Ser Ser Pro Ala Ser Pro Ser Pro Lys Gly Thr Pro Glu Lys Ala 
465                 470                 475                 480


Asn Glu Arg Ala Gly Leu Arg Glu Gly Ser Glu Glu Lys Val Lys Pro 
                485                 490                 495


Pro Arg Pro Arg Ala Pro Glu Ser Asp Thr Gly Asp Glu Asp Gln Asp 
            500                 505                 510


Gln Glu Arg Asp Thr Val Phe Leu Lys Asp Asn His Leu Ala Ile Glu 
        515                 520                 525


Arg Lys Cys Ser Ser Ile Thr Val Ser Ser Thr Ser Ser Leu Glu Ala 
    530                 535                 540


Glu Val Asp Phe Thr Val Ile Gly Asp Tyr His Gly Ser Ala Phe Glu 
545                 550                 555                 560


Asp Phe Ser Arg Ser Leu Pro Glu Leu Asp Arg Asp Lys Ser Asp Ser 
                565                 570                 575


Asp Thr Glu Gly Leu Leu Phe Ser Arg Asp Leu Asn Lys Gly Ala Pro 
            580                 585                 590


Ser Gln Asp Asp Glu Ser Gly Gly Ile Glu Asp Ser Pro Asp Arg Gly 
        595                 600                 605


Ala Cys Ser Thr Pro Asp Met Pro Gln Phe Glu Pro Val Lys Thr Glu 
    610                 615                 620


Thr Met Thr Val Ser Ser Leu Ala Ile Arg Lys Lys Ile Glu Pro Glu 
625                 630                 635                 640


Ala Val Leu Gln Thr Arg Val Ser Ala Met Asp Asn Thr Gln Glu Asn 
                645                 650                 655


Ser Leu Lys Ser Gly Lys Gly Ala Ala Ala Met Ile Pro Gly Pro Gln 
            660                 665                 670


Thr Val Ala Thr Glu Ile Arg Ser Leu Ser Pro Ile Ile Gly Lys Asp 
        675                 680                 685


Val Leu Thr Ser Thr Tyr Gly Ala Thr Ala Glu Thr Leu Ser Thr Ser 
    690                 695                 700


Thr Thr Thr His Val Thr Lys Thr Val Lys Gly Gly Phe Ser Glu Thr 
705                 710                 715                 720


Arg Ile Glu Lys Arg Ile Ile Ile Thr Gly Asp Glu Asp Val Asp Gln 
                725                 730                 735


Asp Gln Ala Leu Ala Leu Ala Ile Lys Glu Ala Lys Leu Gln His Pro 
            740                 745                 750


Asp Met Leu Val Thr Lys Ala Val Val Tyr Arg Glu Thr Asp Pro Ser 
        755                 760                 765


Pro Glu Glu Arg Asp Lys Lys Pro Gln Glu Ser 
    770                 775


<210>  1264
<211>  5205
<212>  DNA
<213>  Homo sapiens

<400>  1264
gagccgccgc cgggtcccgc tcgtctgccg cctcagcctc agccccaacc tcagccgccg     60

ccgttgcgct tgctcccggg cggtcctggc ctgtgccgcc gccgccccca gcgtcggagc    120

catggcgggc gccgcgtccc cttgcgccaa cggctgcggg cccggcgcgc cctcggacgc    180

cgaggtgctg cacctctgcc gcagcctcga ggtgggcacc gtcatgactt tgttctactc    240

caagaagtcg cagcgacccg agcggaagac cttccaggtc aagctggaga cgcgccagat    300

cacgtggagc cggggcgccg acaagatcga gggggccatt gacattcgtg aaattaagga    360

gatccgccca gggaagacct cacgggactt tgatcgctat caagaggacc cagctttccg    420

gccggaccag tcacattgct ttgtcattct ctatggaatg gaatttcgcc tgaaaacgct    480

gagcctgcaa gccacatctg aggatgaagt gaacatgtgg atcaagggct taacttggct    540

gatggaggat acattgcagg cacccacacc cctgcagatt gagaggtggc tccggaagca    600

gttttactca gtggatcgga atcgtgagga tcgtatatca gccaaggacc tgaagaacat    660

gctgtcccag gtcaactacc gggtccccaa catgcgcttc ctccgagagc ggctgacgga    720

cctggagcag cgcagcgggg acatcaccta cgggcagttt gctcagctgt accgcagcct    780

catgtacagc gcccagaaga cgatggacct ccccttcttg gaagccagta ctctgagggc    840

tggggagcgg ccggagcttt gccgagtgtc ccttcctgag ttccagcagt tccttcttga    900

ctaccagggg gagctgtggg ctgttgatcg cctccaggtg caggagttca tgctcagctt    960

cctccgagac cccttacgag agatcgagga gccatacttc ttcctggatg agtttgtcac   1020

cttcctgttc tccaaagaga acagtgtgtg gaactcgcag ctggatgcag tatgcccgga   1080

caccatgaac aaccctcttt cccactactg gatctcctcc tcgcacaaca cgtacctgac   1140

cggggaccag ttctccagtg agtcctcctt ggaagcctat gctcgctgcc tgcggatggg   1200

ctgtcgctgc attgagttgg actgctggga cggcccggat gggatgccag ttatttacca   1260

tgggcacacc cttaccacca agatcaagtt ctcagatgtc ctgcacacca tcaaggagca   1320

tgcctttgtg gcctcagagt acccagtcat cctgtccatt gaggaccact gcagcattgc   1380

ccagcagaga aacatggccc aatacttcaa gaaggtgctg ggggacacac tcctcaccaa   1440

gcccgtggag atctctgccg acgggctccc ctcacccaac cagcttaaga ggaagatcct   1500

catcaagcac aagaagctgg ctgagggcag tgcctacgag gaggtgccta catccatgat   1560

gtactctgag aacgacatca gcaactctat caagaatggc atcctctacc tggaggaccc   1620

tgtgaaccac gaatggtatc cccactactt tgttctgacc agcagcaaga tctactactc   1680

tgaggagacc agcagtgacc agggcaacga ggatgaggag gagcccaagg aggtcagcag   1740

cagcacagag ctgcactcca atgagaagtg gttccatggg aagctagggg cagggcgtga   1800

cgggcgtcac atcgctgagc gcctgcttac tgagtactgc atcgagaccg gagcccctga   1860

cggctccttc ctcgtgcgag agagtgagac cttcgtgggc gactacacgc tctctttctg   1920

gcggaacggg aaagtccagc actgccgtat ccactcccgg caagatgctg ggacccccaa   1980

gttcttcttg acagacaacc tcgtctttga ctccctctat gacctcatca cgcactacca   2040

gcaggtgccc ctgcgctgta atgagtttga gatgcgactt tcagagcctg tcccacagac   2100

caacgcccac gagagcaaag agtggtacca cgcgagcctg accagagcac aggctgagca   2160

catgctaatg cgcgtccctc gtgatggggc cttcctggtg cggaagcgga atgaacccaa   2220

ctcatatgcc atctctttcc gggctgaggg caagatcaag cattgccgtg tccagcaaga   2280

gggccagaca gtgatgctag ggaactcgga gttcgacagc cttgttgacc tcatcagcta   2340

ctatgagaaa cacccgctat accgcaagat gaagctgcgc tatcccatca acgaggaggc   2400

actggagaag attggcacag ctgagcctga ctacggggcc ctgtatgagg gacgcaaccc   2460

tggcttctat gtagaggcaa accctatgcc aactttcaag tgtgcagtca aagccctctt   2520

tgactacaag gcccagaggg aggacgagct gaccttcatc aagagcgcca tcatccagaa   2580

tgtggagaag caagagggag gctggtggcg aggggactac ggagggaaga agcagctgtg   2640

gttcccatca aactacgtgg aagagatggt caaccccgtg gccctggagc cggagaggga   2700

gcacttggac gagaacagcc ccctagggga cttgctgcgg ggggtcttgg atgtgccggc   2760

ttgtcagatt gccatccgtc ctgagggcaa gaacaaccgg ctcttcgtct tctccatcag   2820

catggcgtcg gtggcccact ggtccctgga tgttgctgcc gactcacagg aggagctgca   2880

ggactgggtg aaaaagatcc gtgaagtggc ccagacagca gacgccaggc tcactgaagg   2940

gaagataatg gaacggagga agaagattgc cctggagctc tctgaacttg tcgtctactg   3000

ccggcctgtt ccctttgatg aagagaagat tggcacagaa cgtgcttgct accgggacat   3060

gtcatccttc ccggaaacca aggctgagaa atacgtgaac aaggccaaag gcaagaagtt   3120

ccttcagtac aatcgactgc agctctcccg catctacccc aagggccagc gactggattc   3180

ctccaactac gatcctttgc ccatgtggat ctgtggcagt cagcttgtgg ccctcaactt   3240

ccagacccct gacaagccta tgcagatgaa ccaggccctc ttcatgacgg gcaggcactg   3300

tggctacgtg ctgcagccaa gcaccatgcg ggatgaggcc ttcgacccct ttgacaagag   3360

cagcctccgc gggctggagc catgtgccat ctctattgag gtgctggggg cccgacatct   3420

gccaaagaat ggccgaggca ttgtgtgtcc ttttgtggag attgaggtgg ctggagctga   3480

gtatgacagc accaagcaga agacagagtt tgtggtggac aatggactca accctgtatg   3540

gccagccaag cccttccact tccagatcag taaccctgaa tttgcctttc tgcgcttcgt   3600

ggtgtatgag gaagacatgt ttagtgacca gaatttcctg gctcaggcta ctttcccagt   3660

aaaaggcctg aagacaggat acagagcagt gcctttgaag aacaactaca gtgaggacct   3720

ggagttggcc tccctgctga tcaagattga cattttccct gccaagcagg agaatggtga   3780

cctcagtccc ttcagtggta cgtccctgcg ggagcggggc tcagatgcct caggccagct   3840

gtttcatggc cgagcccggg aaggctcctt tgaatcccgc taccagcagc cgtttgagga   3900

cttccgcatc tcccaggagc atctcgcaga ccattttgac agtcgagaac gaagggcccc   3960

aagaaggact cgggtcaatg gagacaaccg cctctagttg taccccagcc tcgttggaga   4020

gcagcaggtg ctgtgcgcct tgtagaatgc cgcgaactgg gttctttgga agcagccccc   4080

tgtggcggcc ttccgggtct cgcagcctga agcctggatt ccagcagtga atgctagaca   4140

gaaaccaagc cattaatgag atgttattac tgttttgggc ctccatgccc cagctctgga   4200

tgaaggcaaa aactgtactg tgtttcgcat taagcacaca catctggccc tgacttctgg   4260

agatggatcc ttccatcttg tggggccagg accatggccg aagccccttg gagagagagg   4320

ctgcctcagc cagtggcaca ggagactcca aggagctact gacattccta agagtggagg   4380

aggaggagga gccttgctgg gccagggaaa caaagtttac attgtcctgt agctttaaaa   4440

ccacagctgg gcagggtgag aagctagatg cccctgcagt ttggccctgg agccagggca   4500

gaggaatgta gggcctgcat ggagaagggt tctgccctgc ctgaggagga ggacacagca   4560

caagggcaca ttgcccatgg ctgggaacat gacccagcct gaaagataca ggggatcatg   4620

ttaaaaatag cagtattatt tttcgtctca atggtattgt aactaagtta tttactcctc   4680

ctgctcctca cccctgtagg gaaaccttgg agaggagagt ggcaggtggg ctgcctgctg   4740

tgttaagagg acttagtttg tgatgtaagg cactgtcagg aatggggggc gggccagggt   4800

gggaagagaa gaaatagcag agcctatttt ggtgaggttt tttgttttta agtcaaagaa   4860

gactcagtat gctttccctg aggaatgaaa aagggattga ggagttgcct gactcctggg   4920

tgggtggggt acaggcagtt aggtgctgaa tgaagctgcc atccttgctg cagcttctaa   4980

ctggtaaaaa gatccaggga tggagatggg aaggttagaa aggcagccct cacctctgag   5040

gacagaggcc ggggtccagg cccgtgggcg caaaggtgcc tcatagcata gccagcattc   5100

agcacacaca aacctactgc ccacatttgg gctcagggtt ggccatttgc tagttctgct   5160

gccctcttaa gatctgactg ccaaataaat catcctcatg tcctt                   5205


<210>  1265
<211>  1291
<212>  PRT
<213>  Homo sapiens

<400>  1265

Met Ala Gly Ala Ala Ser Pro Cys Ala Asn Gly Cys Gly Pro Gly Ala 
1               5                   10                  15


Pro Ser Asp Ala Glu Val Leu His Leu Cys Arg Ser Leu Glu Val Gly 
            20                  25                  30


Thr Val Met Thr Leu Phe Tyr Ser Lys Lys Ser Gln Arg Pro Glu Arg 
        35                  40                  45


Lys Thr Phe Gln Val Lys Leu Glu Thr Arg Gln Ile Thr Trp Ser Arg 
    50                  55                  60


Gly Ala Asp Lys Ile Glu Gly Ala Ile Asp Ile Arg Glu Ile Lys Glu 
65                  70                  75                  80


Ile Arg Pro Gly Lys Thr Ser Arg Asp Phe Asp Arg Tyr Gln Glu Asp 
                85                  90                  95


Pro Ala Phe Arg Pro Asp Gln Ser His Cys Phe Val Ile Leu Tyr Gly 
            100                 105                 110


Met Glu Phe Arg Leu Lys Thr Leu Ser Leu Gln Ala Thr Ser Glu Asp 
        115                 120                 125


Glu Val Asn Met Trp Ile Lys Gly Leu Thr Trp Leu Met Glu Asp Thr 
    130                 135                 140


Leu Gln Ala Pro Thr Pro Leu Gln Ile Glu Arg Trp Leu Arg Lys Gln 
145                 150                 155                 160


Phe Tyr Ser Val Asp Arg Asn Arg Glu Asp Arg Ile Ser Ala Lys Asp 
                165                 170                 175


Leu Lys Asn Met Leu Ser Gln Val Asn Tyr Arg Val Pro Asn Met Arg 
            180                 185                 190


Phe Leu Arg Glu Arg Leu Thr Asp Leu Glu Gln Arg Ser Gly Asp Ile 
        195                 200                 205


Thr Tyr Gly Gln Phe Ala Gln Leu Tyr Arg Ser Leu Met Tyr Ser Ala 
    210                 215                 220


Gln Lys Thr Met Asp Leu Pro Phe Leu Glu Ala Ser Thr Leu Arg Ala 
225                 230                 235                 240


Gly Glu Arg Pro Glu Leu Cys Arg Val Ser Leu Pro Glu Phe Gln Gln 
                245                 250                 255


Phe Leu Leu Asp Tyr Gln Gly Glu Leu Trp Ala Val Asp Arg Leu Gln 
            260                 265                 270


Val Gln Glu Phe Met Leu Ser Phe Leu Arg Asp Pro Leu Arg Glu Ile 
        275                 280                 285


Glu Glu Pro Tyr Phe Phe Leu Asp Glu Phe Val Thr Phe Leu Phe Ser 
    290                 295                 300


Lys Glu Asn Ser Val Trp Asn Ser Gln Leu Asp Ala Val Cys Pro Asp 
305                 310                 315                 320


Thr Met Asn Asn Pro Leu Ser His Tyr Trp Ile Ser Ser Ser His Asn 
                325                 330                 335


Thr Tyr Leu Thr Gly Asp Gln Phe Ser Ser Glu Ser Ser Leu Glu Ala 
            340                 345                 350


Tyr Ala Arg Cys Leu Arg Met Gly Cys Arg Cys Ile Glu Leu Asp Cys 
        355                 360                 365


Trp Asp Gly Pro Asp Gly Met Pro Val Ile Tyr His Gly His Thr Leu 
    370                 375                 380


Thr Thr Lys Ile Lys Phe Ser Asp Val Leu His Thr Ile Lys Glu His 
385                 390                 395                 400


Ala Phe Val Ala Ser Glu Tyr Pro Val Ile Leu Ser Ile Glu Asp His 
                405                 410                 415


Cys Ser Ile Ala Gln Gln Arg Asn Met Ala Gln Tyr Phe Lys Lys Val 
            420                 425                 430


Leu Gly Asp Thr Leu Leu Thr Lys Pro Val Glu Ile Ser Ala Asp Gly 
        435                 440                 445


Leu Pro Ser Pro Asn Gln Leu Lys Arg Lys Ile Leu Ile Lys His Lys 
    450                 455                 460


Lys Leu Ala Glu Gly Ser Ala Tyr Glu Glu Val Pro Thr Ser Met Met 
465                 470                 475                 480


Tyr Ser Glu Asn Asp Ile Ser Asn Ser Ile Lys Asn Gly Ile Leu Tyr 
                485                 490                 495


Leu Glu Asp Pro Val Asn His Glu Trp Tyr Pro His Tyr Phe Val Leu 
            500                 505                 510


Thr Ser Ser Lys Ile Tyr Tyr Ser Glu Glu Thr Ser Ser Asp Gln Gly 
        515                 520                 525


Asn Glu Asp Glu Glu Glu Pro Lys Glu Val Ser Ser Ser Thr Glu Leu 
    530                 535                 540


His Ser Asn Glu Lys Trp Phe His Gly Lys Leu Gly Ala Gly Arg Asp 
545                 550                 555                 560


Gly Arg His Ile Ala Glu Arg Leu Leu Thr Glu Tyr Cys Ile Glu Thr 
                565                 570                 575


Gly Ala Pro Asp Gly Ser Phe Leu Val Arg Glu Ser Glu Thr Phe Val 
            580                 585                 590


Gly Asp Tyr Thr Leu Ser Phe Trp Arg Asn Gly Lys Val Gln His Cys 
        595                 600                 605


Arg Ile His Ser Arg Gln Asp Ala Gly Thr Pro Lys Phe Phe Leu Thr 
    610                 615                 620


Asp Asn Leu Val Phe Asp Ser Leu Tyr Asp Leu Ile Thr His Tyr Gln 
625                 630                 635                 640


Gln Val Pro Leu Arg Cys Asn Glu Phe Glu Met Arg Leu Ser Glu Pro 
                645                 650                 655


Val Pro Gln Thr Asn Ala His Glu Ser Lys Glu Trp Tyr His Ala Ser 
            660                 665                 670


Leu Thr Arg Ala Gln Ala Glu His Met Leu Met Arg Val Pro Arg Asp 
        675                 680                 685


Gly Ala Phe Leu Val Arg Lys Arg Asn Glu Pro Asn Ser Tyr Ala Ile 
    690                 695                 700


Ser Phe Arg Ala Glu Gly Lys Ile Lys His Cys Arg Val Gln Gln Glu 
705                 710                 715                 720


Gly Gln Thr Val Met Leu Gly Asn Ser Glu Phe Asp Ser Leu Val Asp 
                725                 730                 735


Leu Ile Ser Tyr Tyr Glu Lys His Pro Leu Tyr Arg Lys Met Lys Leu 
            740                 745                 750


Arg Tyr Pro Ile Asn Glu Glu Ala Leu Glu Lys Ile Gly Thr Ala Glu 
        755                 760                 765


Pro Asp Tyr Gly Ala Leu Tyr Glu Gly Arg Asn Pro Gly Phe Tyr Val 
    770                 775                 780


Glu Ala Asn Pro Met Pro Thr Phe Lys Cys Ala Val Lys Ala Leu Phe 
785                 790                 795                 800


Asp Tyr Lys Ala Gln Arg Glu Asp Glu Leu Thr Phe Ile Lys Ser Ala 
                805                 810                 815


Ile Ile Gln Asn Val Glu Lys Gln Glu Gly Gly Trp Trp Arg Gly Asp 
            820                 825                 830


Tyr Gly Gly Lys Lys Gln Leu Trp Phe Pro Ser Asn Tyr Val Glu Glu 
        835                 840                 845


Met Val Asn Pro Val Ala Leu Glu Pro Glu Arg Glu His Leu Asp Glu 
    850                 855                 860


Asn Ser Pro Leu Gly Asp Leu Leu Arg Gly Val Leu Asp Val Pro Ala 
865                 870                 875                 880


Cys Gln Ile Ala Ile Arg Pro Glu Gly Lys Asn Asn Arg Leu Phe Val 
                885                 890                 895


Phe Ser Ile Ser Met Ala Ser Val Ala His Trp Ser Leu Asp Val Ala 
            900                 905                 910


Ala Asp Ser Gln Glu Glu Leu Gln Asp Trp Val Lys Lys Ile Arg Glu 
        915                 920                 925


Val Ala Gln Thr Ala Asp Ala Arg Leu Thr Glu Gly Lys Ile Met Glu 
    930                 935                 940


Arg Arg Lys Lys Ile Ala Leu Glu Leu Ser Glu Leu Val Val Tyr Cys 
945                 950                 955                 960


Arg Pro Val Pro Phe Asp Glu Glu Lys Ile Gly Thr Glu Arg Ala Cys 
                965                 970                 975


Tyr Arg Asp Met Ser Ser Phe Pro Glu Thr Lys Ala Glu Lys Tyr Val 
            980                 985                 990


Asn Lys Ala Lys Gly Lys Lys Phe Leu Gln Tyr Asn Arg Leu Gln Leu 
        995                 1000                1005


Ser Arg Ile Tyr Pro Lys Gly Gln Arg Leu Asp Ser Ser Asn Tyr Asp 
    1010                1015                1020


Pro Leu Pro Met Trp Ile Cys Gly Ser Gln Leu Val Ala Leu Asn Phe 
1025                1030                1035                1040


Gln Thr Pro Asp Lys Pro Met Gln Met Asn Gln Ala Leu Phe Met Thr 
                1045                1050                1055


Gly Arg His Cys Gly Tyr Val Leu Gln Pro Ser Thr Met Arg Asp Glu 
            1060                1065                1070


Ala Phe Asp Pro Phe Asp Lys Ser Ser Leu Arg Gly Leu Glu Pro Cys 
        1075                1080                1085


Ala Ile Ser Ile Glu Val Leu Gly Ala Arg His Leu Pro Lys Asn Gly 
    1090                1095                1100


Arg Gly Ile Val Cys Pro Phe Val Glu Ile Glu Val Ala Gly Ala Glu 
1105                1110                1115                1120


Tyr Asp Ser Thr Lys Gln Lys Thr Glu Phe Val Val Asp Asn Gly Leu 
                1125                1130                1135


Asn Pro Val Trp Pro Ala Lys Pro Phe His Phe Gln Ile Ser Asn Pro 
            1140                1145                1150


Glu Phe Ala Phe Leu Arg Phe Val Val Tyr Glu Glu Asp Met Phe Ser 
        1155                1160                1165


Asp Gln Asn Phe Leu Ala Gln Ala Thr Phe Pro Val Lys Gly Leu Lys 
    1170                1175                1180


Thr Gly Tyr Arg Ala Val Pro Leu Lys Asn Asn Tyr Ser Glu Asp Leu 
1185                1190                1195                1200


Glu Leu Ala Ser Leu Leu Ile Lys Ile Asp Ile Phe Pro Ala Lys Gln 
                1205                1210                1215


Glu Asn Gly Asp Leu Ser Pro Phe Ser Gly Thr Ser Leu Arg Glu Arg 
            1220                1225                1230


Gly Ser Asp Ala Ser Gly Gln Leu Phe His Gly Arg Ala Arg Glu Gly 
        1235                1240                1245


Ser Phe Glu Ser Arg Tyr Gln Gln Pro Phe Glu Asp Phe Arg Ile Ser 
    1250                1255                1260


Gln Glu His Leu Ala Asp His Phe Asp Ser Arg Glu Arg Arg Ala Pro 
1265                1270                1275                1280


Arg Arg Thr Arg Val Asn Gly Asp Asn Arg Leu 
                1285                1290


<210>  1266
<211>  5202
<212>  DNA
<213>  Homo sapiens

<400>  1266
gagccgccgc cgggtcccgc tcgtctgccg cctcagcctc agccccaacc tcagccgccg     60

ccgttgcgct tgctcccggg cggtcctggc ctgtgccgcc gccgccccca gcgtcggagc    120

catggcgggc gccgcgtccc cttgcgccaa cggctgcggg cccggcgcgc cctcggacgc    180

cgaggtgctg cacctctgcc gcagcctcga ggtgggcacc gtcatgactt tgttctactc    240

caagaagtcg cagcgacccg agcggaagac cttccaggtc aagctggaga cgcgccagat    300

cacgtggagc cggggcgccg acaagatcga gggggccatt gacattcgtg aaattaagga    360

gatccgccca gggaagacct cacgggactt tgatcgctat caagaggacc cagctttccg    420

gccggaccag tcacattgct ttgtcattct ctatggaatg gaatttcgcc tgaaaacgct    480

gagcctgcaa gccacatctg aggatgaagt gaacatgtgg atcaagggct taacttggct    540

gatggaggat acattgcagg cacccacacc cctgcagatt gagaggtggc tccggaagca    600

gttttactca gtggatcgga atcgtgagga tcgtatatca gccaaggacc tgaagaacat    660

gctgtcccag gtcaactacc gggtccccaa catgcgcttc ctccgagagc ggctgacgga    720

cctggagcag cgcagcgggg acatcaccta cgggcagttt gctcagctgt accgcagcct    780

catgtacagc gcccagaaga cgatggacct ccccttcttg gaagccagta ctctgagggc    840

tggggagcgg ccggagcttt gccgagtgtc ccttcctgag ttccagcagt tccttcttga    900

ctaccagggg gagctgtggg ctgttgatcg cctccaggtg caggagttca tgctcagctt    960

cctccgagac cccttacgag agatcgagga gccatacttc ttcctggatg agtttgtcac   1020

cttcctgttc tccaaagaga acagtgtgtg gaactcgcag ctggatgcag tatgcccgga   1080

caccatgaac aaccctcttt cccactactg gatctcctcc tcgcacaaca cgtacctgac   1140

cggggaccag ttctccagtg agtcctcctt ggaagcctat gctcgctgcc tgcggatggg   1200

ctgtcgctgc attgagttgg actgctggga cggcccggat gggatgccag ttatttacca   1260

tgggcacacc cttaccacca agatcaagtt ctcagatgtc ctgcacacca tcaaggagca   1320

tgcctttgtg gcctcagagt acccagtcat cctgtccatt gaggaccact gcagcattgc   1380

ccagcagaga aacatggccc aatacttcaa gaaggtgctg ggggacacac tcctcaccaa   1440

gcccgtggag atctctgccg acgggctccc ctcacccaac cagcttaaga ggaagatcct   1500

catcaagcac aagaagctgg ctgagggcag tgcctacgag gaggtgccta catccatgat   1560

gtactctgag aacgacatca gcaactctat caagaatggc atcctctacc tggaggaccc   1620

tgtgaaccac gaatggtatc cccactactt tgttctgacc agcagcaaga tctactactc   1680

tgaggagacc agcagtgacc agggcaacga ggatgaggag gagcccaagg aggtcagcag   1740

cagcacagag ctgcactcca atgagaagtg gttccatggg aagctagggg cagggcgtga   1800

cgggcgtcac atcgctgagc gcctgcttac tgagtactgc atcgagaccg gagcccctga   1860

cggctccttc ctcgtgcgag agagtgagac cttcgtgggc gactacacgc tctctttctg   1920

gcggaacggg aaagtccagc actgccgtat ccactcccgg caagatgctg ggacccccaa   1980

gttcttcttg acagacaacc tcgtctttga ctccctctat gacctcatca cgcactacca   2040

gcaggtgccc ctgcgctgta atgagtttga gatgcgactt tcagagcctg tcccacagac   2100

caacgcccac gagagcaaag agtggtacca cgcgagcctg accagagcac aggctgagca   2160

catgctaatg cgcgtccctc gtgatggggc cttcctggtg cggaagcgga atgaacccaa   2220

ctcatatgcc atctctttcc gggctgaggg caagatcaag cattgccgtg tccagcaaga   2280

gggccagaca gtgatgctag ggaactcgga gttcgacagc cttgttgacc tcatcagcta   2340

ctatgagaaa cacccgctat accgcaagat gaagctgcgc tatcccatca acgaggaggc   2400

actggagaag attggcacag ctgagcctga ctacggggcc ctgtatgagg gacgcaaccc   2460

tggcttctat gtagaggcaa accctatgcc aactttcaag tgtgcagtca aagccctctt   2520

tgactacaag gcccagaggg aggacgagct gaccttcatc aagagcgcca tcatccagaa   2580

tgtggagaag caagagggag gctggtggcg aggggactac ggagggaaga agcagctgtg   2640

gttcccatca aactacgtgg aagagatggt caaccccgtg gccctggagc cggagaggga   2700

gcacttggac gagaacagcc ccctagggga cttgctgcgg ggggtcttgg atgtgccggc   2760

ttgtcagatt gccatccgtc ctgagggcaa gaacaaccgg ctcttcgtct tctccatcag   2820

catggcgtcg gtggcccact ggtccctgga tgttgctgcc gactcacagg aggagctgca   2880

ggactgggtg aaaaagatcc gtgaagtggc ccagacagca gacgccaggc tcactgaagg   2940

gaagataatg gaacggagga agaagattgc cctggagctc tctgaacttg tcgtctactg   3000

ccggcctgtt ccctttgatg aagagaagat tggcacagaa cgtgcttgct accgggacat   3060

gtcatccttc ccggaaacca aggctgagaa atacgtgaac aaggccaaag gcaagaagtt   3120

ccttcagtac aatcgactgc agctctcccg catctacccc aagggccagc gactggattc   3180

ctccaactac gatcctttgc ccatgtggat ctgtggcagt cagcttgtgg ccctcaactt   3240

ccagacccct gacaagccta tgcagatgaa ccaggccctc ttcatgacgg gcaggcactg   3300

tggctacgtg ctgcagccaa gcaccatgcg ggatgaggcc ttcgacccct ttgacaagag   3360

cagcctccgc gggctggagc catgtgccat ctctattgag gtgctggggg cccgacatct   3420

gccaaagaat ggccgaggca ttgtgtgtcc ttttgtggag attgaggtgg ctggagctga   3480

gtatgacagc accaagcaga agacagagtt tgtggtggac aatggactca accctgtatg   3540

gccagccaag cccttccact tccagatcag taaccctgaa tttgcctttc tgcgcttcgt   3600

ggtgtatgag gaagacatgt ttagtgacca gaatttcctg gctcaggcta ctttcccagt   3660

aaaaggcctg aagacaggat acagagcagt gcctttgaag aacaactaca gtgaggacct   3720

ggagttggcc tccctgctga tcaagattga cattttccct gccaaggaga atggtgacct   3780

cagtcccttc agtggtacgt ccctgcggga gcggggctca gatgcctcag gccagctgtt   3840

tcatggccga gcccgggaag gctcctttga atcccgctac cagcagccgt ttgaggactt   3900

ccgcatctcc caggagcatc tcgcagacca ttttgacagt cgagaacgaa gggccccaag   3960

aaggactcgg gtcaatggag acaaccgcct ctagttgtac cccagcctcg ttggagagca   4020

gcaggtgctg tgcgccttgt agaatgccgc gaactgggtt ctttggaagc agccccctgt   4080

ggcggccttc cgggtctcgc agcctgaagc ctggattcca gcagtgaatg ctagacagaa   4140

accaagccat taatgagatg ttattactgt tttgggcctc catgccccag ctctggatga   4200

aggcaaaaac tgtactgtgt ttcgcattaa gcacacacat ctggccctga cttctggaga   4260

tggatccttc catcttgtgg ggccaggacc atggccgaag ccccttggag agagaggctg   4320

cctcagccag tggcacagga gactccaagg agctactgac attcctaaga gtggaggagg   4380

aggaggagcc ttgctgggcc agggaaacaa agtttacatt gtcctgtagc tttaaaacca   4440

cagctgggca gggtgagaag ctagatgccc ctgcagtttg gccctggagc cagggcagag   4500

gaatgtaggg cctgcatgga gaagggttct gccctgcctg aggaggagga cacagcacaa   4560

gggcacattg cccatggctg ggaacatgac ccagcctgaa agatacaggg gatcatgtta   4620

aaaatagcag tattattttt cgtctcaatg gtattgtaac taagttattt actcctcctg   4680

ctcctcaccc ctgtagggaa accttggaga ggagagtggc aggtgggctg cctgctgtgt   4740

taagaggact tagtttgtga tgtaaggcac tgtcaggaat ggggggcggg ccagggtggg   4800

aagagaagaa atagcagagc ctattttggt gaggtttttt gtttttaagt caaagaagac   4860

tcagtatgct ttccctgagg aatgaaaaag ggattgagga gttgcctgac tcctgggtgg   4920

gtggggtaca ggcagttagg tgctgaatga agctgccatc cttgctgcag cttctaactg   4980

gtaaaaagat ccagggatgg agatgggaag gttagaaagg cagccctcac ctctgaggac   5040

agaggccggg gtccaggccc gtgggcgcaa aggtgcctca tagcatagcc agcattcagc   5100

acacacaaac ctactgccca catttgggct cagggttggc catttgctag ttctgctgcc   5160

ctcttaagat ctgactgcca aataaatcat cctcatgtcc tt                      5202


<210>  1267
<211>  1290
<212>  PRT
<213>  Homo sapiens

<400>  1267

Met Ala Gly Ala Ala Ser Pro Cys Ala Asn Gly Cys Gly Pro Gly Ala 
1               5                   10                  15


Pro Ser Asp Ala Glu Val Leu His Leu Cys Arg Ser Leu Glu Val Gly 
            20                  25                  30


Thr Val Met Thr Leu Phe Tyr Ser Lys Lys Ser Gln Arg Pro Glu Arg 
        35                  40                  45


Lys Thr Phe Gln Val Lys Leu Glu Thr Arg Gln Ile Thr Trp Ser Arg 
    50                  55                  60


Gly Ala Asp Lys Ile Glu Gly Ala Ile Asp Ile Arg Glu Ile Lys Glu 
65                  70                  75                  80


Ile Arg Pro Gly Lys Thr Ser Arg Asp Phe Asp Arg Tyr Gln Glu Asp 
                85                  90                  95


Pro Ala Phe Arg Pro Asp Gln Ser His Cys Phe Val Ile Leu Tyr Gly 
            100                 105                 110


Met Glu Phe Arg Leu Lys Thr Leu Ser Leu Gln Ala Thr Ser Glu Asp 
        115                 120                 125


Glu Val Asn Met Trp Ile Lys Gly Leu Thr Trp Leu Met Glu Asp Thr 
    130                 135                 140


Leu Gln Ala Pro Thr Pro Leu Gln Ile Glu Arg Trp Leu Arg Lys Gln 
145                 150                 155                 160


Phe Tyr Ser Val Asp Arg Asn Arg Glu Asp Arg Ile Ser Ala Lys Asp 
                165                 170                 175


Leu Lys Asn Met Leu Ser Gln Val Asn Tyr Arg Val Pro Asn Met Arg 
            180                 185                 190


Phe Leu Arg Glu Arg Leu Thr Asp Leu Glu Gln Arg Ser Gly Asp Ile 
        195                 200                 205


Thr Tyr Gly Gln Phe Ala Gln Leu Tyr Arg Ser Leu Met Tyr Ser Ala 
    210                 215                 220


Gln Lys Thr Met Asp Leu Pro Phe Leu Glu Ala Ser Thr Leu Arg Ala 
225                 230                 235                 240


Gly Glu Arg Pro Glu Leu Cys Arg Val Ser Leu Pro Glu Phe Gln Gln 
                245                 250                 255


Phe Leu Leu Asp Tyr Gln Gly Glu Leu Trp Ala Val Asp Arg Leu Gln 
            260                 265                 270


Val Gln Glu Phe Met Leu Ser Phe Leu Arg Asp Pro Leu Arg Glu Ile 
        275                 280                 285


Glu Glu Pro Tyr Phe Phe Leu Asp Glu Phe Val Thr Phe Leu Phe Ser 
    290                 295                 300


Lys Glu Asn Ser Val Trp Asn Ser Gln Leu Asp Ala Val Cys Pro Asp 
305                 310                 315                 320


Thr Met Asn Asn Pro Leu Ser His Tyr Trp Ile Ser Ser Ser His Asn 
                325                 330                 335


Thr Tyr Leu Thr Gly Asp Gln Phe Ser Ser Glu Ser Ser Leu Glu Ala 
            340                 345                 350


Tyr Ala Arg Cys Leu Arg Met Gly Cys Arg Cys Ile Glu Leu Asp Cys 
        355                 360                 365


Trp Asp Gly Pro Asp Gly Met Pro Val Ile Tyr His Gly His Thr Leu 
    370                 375                 380


Thr Thr Lys Ile Lys Phe Ser Asp Val Leu His Thr Ile Lys Glu His 
385                 390                 395                 400


Ala Phe Val Ala Ser Glu Tyr Pro Val Ile Leu Ser Ile Glu Asp His 
                405                 410                 415


Cys Ser Ile Ala Gln Gln Arg Asn Met Ala Gln Tyr Phe Lys Lys Val 
            420                 425                 430


Leu Gly Asp Thr Leu Leu Thr Lys Pro Val Glu Ile Ser Ala Asp Gly 
        435                 440                 445


Leu Pro Ser Pro Asn Gln Leu Lys Arg Lys Ile Leu Ile Lys His Lys 
    450                 455                 460


Lys Leu Ala Glu Gly Ser Ala Tyr Glu Glu Val Pro Thr Ser Met Met 
465                 470                 475                 480


Tyr Ser Glu Asn Asp Ile Ser Asn Ser Ile Lys Asn Gly Ile Leu Tyr 
                485                 490                 495


Leu Glu Asp Pro Val Asn His Glu Trp Tyr Pro His Tyr Phe Val Leu 
            500                 505                 510


Thr Ser Ser Lys Ile Tyr Tyr Ser Glu Glu Thr Ser Ser Asp Gln Gly 
        515                 520                 525


Asn Glu Asp Glu Glu Glu Pro Lys Glu Val Ser Ser Ser Thr Glu Leu 
    530                 535                 540


His Ser Asn Glu Lys Trp Phe His Gly Lys Leu Gly Ala Gly Arg Asp 
545                 550                 555                 560


Gly Arg His Ile Ala Glu Arg Leu Leu Thr Glu Tyr Cys Ile Glu Thr 
                565                 570                 575


Gly Ala Pro Asp Gly Ser Phe Leu Val Arg Glu Ser Glu Thr Phe Val 
            580                 585                 590


Gly Asp Tyr Thr Leu Ser Phe Trp Arg Asn Gly Lys Val Gln His Cys 
        595                 600                 605


Arg Ile His Ser Arg Gln Asp Ala Gly Thr Pro Lys Phe Phe Leu Thr 
    610                 615                 620


Asp Asn Leu Val Phe Asp Ser Leu Tyr Asp Leu Ile Thr His Tyr Gln 
625                 630                 635                 640


Gln Val Pro Leu Arg Cys Asn Glu Phe Glu Met Arg Leu Ser Glu Pro 
                645                 650                 655


Val Pro Gln Thr Asn Ala His Glu Ser Lys Glu Trp Tyr His Ala Ser 
            660                 665                 670


Leu Thr Arg Ala Gln Ala Glu His Met Leu Met Arg Val Pro Arg Asp 
        675                 680                 685


Gly Ala Phe Leu Val Arg Lys Arg Asn Glu Pro Asn Ser Tyr Ala Ile 
    690                 695                 700


Ser Phe Arg Ala Glu Gly Lys Ile Lys His Cys Arg Val Gln Gln Glu 
705                 710                 715                 720


Gly Gln Thr Val Met Leu Gly Asn Ser Glu Phe Asp Ser Leu Val Asp 
                725                 730                 735


Leu Ile Ser Tyr Tyr Glu Lys His Pro Leu Tyr Arg Lys Met Lys Leu 
            740                 745                 750


Arg Tyr Pro Ile Asn Glu Glu Ala Leu Glu Lys Ile Gly Thr Ala Glu 
        755                 760                 765


Pro Asp Tyr Gly Ala Leu Tyr Glu Gly Arg Asn Pro Gly Phe Tyr Val 
    770                 775                 780


Glu Ala Asn Pro Met Pro Thr Phe Lys Cys Ala Val Lys Ala Leu Phe 
785                 790                 795                 800


Asp Tyr Lys Ala Gln Arg Glu Asp Glu Leu Thr Phe Ile Lys Ser Ala 
                805                 810                 815


Ile Ile Gln Asn Val Glu Lys Gln Glu Gly Gly Trp Trp Arg Gly Asp 
            820                 825                 830


Tyr Gly Gly Lys Lys Gln Leu Trp Phe Pro Ser Asn Tyr Val Glu Glu 
        835                 840                 845


Met Val Asn Pro Val Ala Leu Glu Pro Glu Arg Glu His Leu Asp Glu 
    850                 855                 860


Asn Ser Pro Leu Gly Asp Leu Leu Arg Gly Val Leu Asp Val Pro Ala 
865                 870                 875                 880


Cys Gln Ile Ala Ile Arg Pro Glu Gly Lys Asn Asn Arg Leu Phe Val 
                885                 890                 895


Phe Ser Ile Ser Met Ala Ser Val Ala His Trp Ser Leu Asp Val Ala 
            900                 905                 910


Ala Asp Ser Gln Glu Glu Leu Gln Asp Trp Val Lys Lys Ile Arg Glu 
        915                 920                 925


Val Ala Gln Thr Ala Asp Ala Arg Leu Thr Glu Gly Lys Ile Met Glu 
    930                 935                 940


Arg Arg Lys Lys Ile Ala Leu Glu Leu Ser Glu Leu Val Val Tyr Cys 
945                 950                 955                 960


Arg Pro Val Pro Phe Asp Glu Glu Lys Ile Gly Thr Glu Arg Ala Cys 
                965                 970                 975


Tyr Arg Asp Met Ser Ser Phe Pro Glu Thr Lys Ala Glu Lys Tyr Val 
            980                 985                 990


Asn Lys Ala Lys Gly Lys Lys Phe Leu Gln Tyr Asn Arg Leu Gln Leu 
        995                 1000                1005


Ser Arg Ile Tyr Pro Lys Gly Gln Arg Leu Asp Ser Ser Asn Tyr Asp 
    1010                1015                1020


Pro Leu Pro Met Trp Ile Cys Gly Ser Gln Leu Val Ala Leu Asn Phe 
1025                1030                1035                1040


Gln Thr Pro Asp Lys Pro Met Gln Met Asn Gln Ala Leu Phe Met Thr 
                1045                1050                1055


Gly Arg His Cys Gly Tyr Val Leu Gln Pro Ser Thr Met Arg Asp Glu 
            1060                1065                1070


Ala Phe Asp Pro Phe Asp Lys Ser Ser Leu Arg Gly Leu Glu Pro Cys 
        1075                1080                1085


Ala Ile Ser Ile Glu Val Leu Gly Ala Arg His Leu Pro Lys Asn Gly 
    1090                1095                1100


Arg Gly Ile Val Cys Pro Phe Val Glu Ile Glu Val Ala Gly Ala Glu 
1105                1110                1115                1120


Tyr Asp Ser Thr Lys Gln Lys Thr Glu Phe Val Val Asp Asn Gly Leu 
                1125                1130                1135


Asn Pro Val Trp Pro Ala Lys Pro Phe His Phe Gln Ile Ser Asn Pro 
            1140                1145                1150


Glu Phe Ala Phe Leu Arg Phe Val Val Tyr Glu Glu Asp Met Phe Ser 
        1155                1160                1165


Asp Gln Asn Phe Leu Ala Gln Ala Thr Phe Pro Val Lys Gly Leu Lys 
    1170                1175                1180


Thr Gly Tyr Arg Ala Val Pro Leu Lys Asn Asn Tyr Ser Glu Asp Leu 
1185                1190                1195                1200


Glu Leu Ala Ser Leu Leu Ile Lys Ile Asp Ile Phe Pro Ala Lys Glu 
                1205                1210                1215


Asn Gly Asp Leu Ser Pro Phe Ser Gly Thr Ser Leu Arg Glu Arg Gly 
            1220                1225                1230


Ser Asp Ala Ser Gly Gln Leu Phe His Gly Arg Ala Arg Glu Gly Ser 
        1235                1240                1245


Phe Glu Ser Arg Tyr Gln Gln Pro Phe Glu Asp Phe Arg Ile Ser Gln 
    1250                1255                1260


Glu His Leu Ala Asp His Phe Asp Ser Arg Glu Arg Arg Ala Pro Arg 
1265                1270                1275                1280


Arg Thr Arg Val Asn Gly Asp Asn Arg Leu 
                1285                1290


<210>  1268
<211>  9991
<212>  DNA
<213>  Homo sapiens

<400>  1268
gtgatagccg tcaaaggcag caaatagact gaatgaaaga tgagcttctg cctttatatc     60

cttctctcct gctacccaac tcattgtggt gaaggaaaaa gaaaacgcgg gtggagactg    120

cactatatgc ttaggactga aatgcaactg cagaagcaac atgtgacctt ttagagatgc    180

ttgtgggact gcataaagtg aagagggaaa ctggaaaaaa acaatgaaat tgaataggga    240

aaacctgctt tctgcaaaca actgaaaaag ctgcatttag aaactgtttc tttggccctc    300

atcgagaagc tggaacttgt attgttaggc cccttatggg acaagctctc aactgctgat    360

cacccagtga ttgtcaccat ggccagcaag aggaaatcca ccacaccatg catgatccca    420

gtgaagactg tggtgttgca agatgccagc atggaggccc agcccgctga gaccttgcct    480

gaaggacccc agcaggatct gcccccagaa gcatctgctg ccagcagtga ggcagcacag    540

aaccccagca gtactgatgg ctctacactg gccaatgggc atcggagcac tttagatggc    600

tatttatatt cctgtaaata ctgcgatttc agatcccatg acatgaccca atttgtggga    660

catatgaact cagagcacac agactttaat aaagacccaa cctttgtatg cagtgggtgc    720

agttttctgg caaaaacccc tgaggggctt tccttgcaca atgccacatg tcactccggg    780

gaagccagct ttgtgtggaa cgtggccaag ccagacaatc atgtggttgt ggagcagagc    840

atccctgaga gcaccagcac tcctgaccta gcgggtgagc ccagtgctga aggggctgat    900

ggacaggcag aaatcatcat taccaaaact ccaatcatga agataatgaa aggcaaagct    960

gaagccaaaa aaattcatac actcaaggag aatgtcccta gccagcctgt gggtgaggcc   1020

ttaccaaagc tgtcgactgg agaaatggag gtgagagagg gggaccattc cttcatcaat   1080

ggggcagttc cagtcagcca ggcatctgcc agctctgcaa aaaaccccca tgccgccaac   1140

gggcccctga taggaacagt gccagttttg ccagctggca tagcacagtt cctctccctc   1200

cagcagcagc ccccagtgca tgcccaacac catgtccacc agccactgcc cacggccaag   1260

gcccttccca aagtgatgat ccccctgagc agcattccaa cgtacaatgc agccatggac   1320

tctaacagct tcctgaagaa ctccttccac aagttcccct accccaccaa agccgagctc   1380

tgctatttga ctgtggtgac caagtatcca gaagaacagc tcaagatctg gttcacagcc   1440

caaaggctga agcaggggat cagctggtcc cctgaggaga ttgaggatgc ccggaaaaag   1500

atgttcaata cagtcatcca gtctgtgcct cagcccacaa ttacggttct aaatacccca   1560

ctcgtcgcca gtgctggcaa tgtccagcat ctcatccagg ccgctcttcc aggtcacgtt   1620

gtggggcagc cagagggtac aggaggggga cttctggtca ctcagccatt gatggccaat   1680

gggttgcaag caacaagttc ccctctcccc ctcacggtga catccgtccc caagcagcca   1740

ggtgtggcac ccattaacac tgtgtgttca aatacaacgt cagctgtgaa ggtggtcaat   1800

gcggcccagt cgctcctcac ggcctgcccc agcataacct cccaagcctt ccttgatgct   1860

agcatctaca aaaataagaa atctcatgaa cagctgtcag ctctgaaagg gagcttctgt   1920

cggaaccagt tcccagggca gagcgaagtt gaacatctca caaaagtgac gggcctcagt   1980

accagagagg tgcggaaatg gttcagtgat cgtagatacc actgccggaa cttgaagggc   2040

tccagagcga tgatacctgg agatcacagt tccatcatca ttgactctgt gccagaggtg   2100

tccttctccc catcgtccaa ggtccctgag gtaacctgca ttccgacaac agccacacta   2160

gcaacccacc cttctgccaa acgacaatct tggcaccaga ctcctgactt cacaccaacc   2220

aaatacaagg agagagcccc tgagcagctc agagccctgg agagcagttt tgcacaaaac   2280

cctcttcctc ttgatgagga actggaccgc ctgagaagtg aaaccaaaat gacccgacga   2340

gaaattgata gctggttttc agagagacgg aaaaaagtga atgctgagga gaccaagaag   2400

gctgaggaga atgcctctca ggaggaagag gaggctgctg aggatgaggg tggagaagag   2460

gatttggcca gtgagctaag ggtctctggt gaaaatggct ctctggaaat gcccagcagc   2520

catatcttgg cagagcgcaa agtcagcccc attaaaatca acctgaagaa cctgagggtc   2580

actgaagcca atggcaggaa cgagattcca gggctgggtg cctgtgaccc tgaggatgat   2640

gagtcaaaca aactggcaga gcagctccca ggcaaagtga gctgcaaaaa gactgcccag   2700

cagcggcact tgctgcggca gctctttgtc cagacacagt ggccaagcaa ccaggactat   2760

gactccatca tggcccagac gggtctgcca cggccagagg tggtgcgctg gtttggagat   2820

agcaggtacg cactgaagaa cggccaactc aaatggtacg aagactataa gcgaggcaac   2880

ttcccaccag ggctactggt cattgcccct ggcaaccggg agctcctgca ggactattac   2940

atgacacaca agatgctgta tgaagaggac ctgcagaacc tctgtgacaa gacccagatg   3000

agctcccagc aggtcaagca gtggtttgct gagaaaatgg gggaggagac cagagccgtg   3060

gcagacacag gcagtgagga ccagggccct ggtactggtg agctcacagc agttcacaaa   3120

gggatgggtg acacctattc agaggtgtct gagaacagtg agtcgtggga gccccgtgtc   3180

cctgaggcca gctcagagcc ctttgacaca tcgagtcccc aggctggacg tcagctcgaa   3240

acagactgaa tttgatctga ttaatgtgaa ggactggcca gtctgggaaa ccgcctgcca   3300

cgtggaagag ccaaacccga ctctctgctg ccacatgccg ttcccatgcc cggctgctgg   3360

gcacctggga gagcttccag aatcctcgca gacagcccag agcctgccgc taccctcggc   3420

ctgcccacca ccaagcaagc agcaagcaag atggggttct catcagttct tcctcccaca   3480

atgtaggacc tttcctttac cttccaatgg ataaaatagt tcagagttca tagtcatatt   3540

catagacaca gaatcaagct tttaacatat acatccacct ctatatgtta aataaaacat   3600

cagattatca acactgtcat tacgtagaaa ctttggttag ccaagcagtg cattgtcagt   3660

tacgtcatct ctaaaaatga cctgtgtctg ttctctgggg attgctgggt cacaggtgcc   3720

cctcaccttc cacagtcagg cagggaagtt ataggcacaa agctacgtct ggaacccctt   3780

tgtgccccct ttgtgttcct caaggaagca gtacctttga agagatctct gctgcattaa   3840

gtgatgaccg gctacgtttc atgtcaggct tgctttgcct tgtgggctac tcagtgcaga   3900

acctgctgta accctcagtt caaaaaatgg actggcaatg tgattagcgt tggatgcttt   3960

accattctct ttagttgtta ccgtaattct gctttttcat gggagtttga atcatggacc   4020

ataacttttc agttatcaga tcaactaaag aaacatttgt tgttaagcct aatgtgctga   4080

cctatgtgcc tgcatttttt ttttaatcta gacatgtttg gagtgagaga aagatggaaa   4140

aaagacatgg ggtagggacg taagtggaaa tctatagcca cagcctgaag ctttgaccac   4200

tgcggttttc agagcccttt ctccacactc atttcagagc ctcctatggt ttgggaagga   4260

ataacacact ggcccattag taagggtgaa ggctggaggg atttgttgac ttcttggaat   4320

tatcagaggt agggtggtct ttagcacaaa gacttgcatg cagagatccc tggcagaaca   4380

cccagagtgc ccgtggctcc caccccaggg tctggccggt gtgctggatg catgcccaag   4440

ggtgctgggc atcactggtc cttgtgagga tgcttttaaa gttttatatt tatgtcccca   4500

aacttggaaa caagaactct actttagcct aaccctcatg tccttttttg aattgagaaa   4560

attacaggaa atggtgcctt tgaaaattag aaaacttgct tacagagctg ttctaaatgg   4620

taaatcctca atttccccaa gaccggttgc tctgagagta gctggtaaag aggggcgaac   4680

taaagacctg tccacctgta gctccgctca tttcttagaa accacctgct tcccagagtg   4740

ccaagccaca agtaccaggc ttcgtgggca cagacacctc ctgggctggg cagagtgaca   4800

gtgctagaag accccagaga gagggcaagg gctttgggca agaagcactg gtggtgtttt   4860

agggaccgtc cttctcccct acccagggaa ctggacctgg cagggcaccg tgctcatgtg   4920

gctccaagga caagcatggc ggtggcccct tctgccttcc aggagaggtc ttgcttttga   4980

aaccaaaatc atgttcttct aaagtgtcat cttctgccct ccctgtccca atagggacca   5040

catcttattt gtctcaaaca gggacttgtg agtacttggc aagttttgca gcctattttt   5100

gtattcttaa tttggggagt aaagatgttt ggtctcaaaa acctttgagg aattgccaag   5160

aatggcgagt gattgctttc cttcagagaa cagacacttg gaatttctcc ttttagtgtt   5220

tatatacgtg cagattaatt tatatatata tatatacaca cacacatata cagtataaat   5280

actcatttga ttctcgtaaa acgcgcatct ggcgtgtgca gttgagaaac ttggtggcac   5340

atgggtgttg ggggagtagc ctgtgttgga gggacaccag tgcactaggc agctggggcg   5400

gcccaggctg aagccatctc cgggtgtctg agaaaccacc cagtgcctca cctccagatc   5460

ctgctggcat cacctccaga gccctgcatg cactggctga agagttggtc tgtggagagg   5520

attttcttgg ttacttgtat tcacggttaa tttacaaccc aaacagcaaa acacagttgg   5580

tggacaagtt catgcaggac ctacagtgac ccagccatgg gcactagctc atctttcagg   5640

tggaaaagta cagtgctgcc tgccctggta tgtttttctt atagatgtta gccctgccca   5700

acagccaggg ctacactaca aaaggcaaga atgcccatgt aaggagccca gcagtctgga   5760

cagatccttc ttcctctgct gttggatgag agtgagtgag tatgctctgg accttatcct   5820

tgaaagatga tcaaaagcga tgatgaggga ggcagtcatc acgcaggtgc ttaaagggac   5880

attgtaggag gtactcaagg gtttgggggc aaaaccctga atccagccag tcgtgcacag   5940

agacacaccc acactagccc agtggcagtg ggggatgtgg gatggcagca gccaggtatg   6000

tagccctgtc acaggacagc tcactgtggt tttgcacact gcctaagggt taaattgtgt   6060

tgttgccttc agtagaaggc atttgtgggc tgcagagttg agagttgggt gaggttagtc   6120

tctcctgaag aaaaagccta taaaaagtgg ctaatcttat cccttttctc tgtatgcagt   6180

tggactcgtc agagatagta aaatcatctt ttagtgtttt tttgttgctg atgtcttgta   6240

cccatttgtt ttttacatgg ggttgtagat cgagttctca aaggtgaaac cagatgatca   6300

ttctgataaa ggaaatttaa atttgataca tatgctttgt atattttgat tacttgtttt   6360

cgtttttgac tataaaggag cttttttatt ttgggagggg aggagtgtca tttttgagaa   6420

tcttgggttc ctgaaaaaga acgccctagt tggatggctt gccagggcct tggggtttgg   6480

tagtgattgt acaacttaaa gctcctttct cttggctgag tgacaggtgg ctgttcaggt   6540

ggaccaaagc accttgacac aaggactcca cactgtgctc tctagtagca caaggaggaa   6600

gttggacaga acattgggta gtgccttgcg ggctcacaca tgtactagtg gtctcatctc   6660

cagctagcct tgggaggccg tcccaccagg aaatctctct attccgtagc ctgagatgtg   6720

cccttgtggg ttttatcctg ctcagtcagt ggcctagggg caggtcctgt gttctctccc   6780

tctctctcct ggctctggga catctgtccc tggctgcctt tcatggagga aggacactgg   6840

cctttctggt tggatgctgt gtggatgctc tctgcttgag cctcgtggtc tcttgtctct   6900

ttttggacca atatcctcag attggtgcag ctttttcagt tcagatatca caccccaagt   6960

ggataaaggc aacttgcagg agaggagagc cagccaagaa gaaaatttta aaaccaaacc   7020

tcgtttagga ttttcctaaa gtcatcttct cttttttctt gctcagagtt tacctgggag   7080

atttcaccag tttgactcac catttgcaga tgtgcttttg tattaaattt aaattttcac   7140

atatcacatc cattctcaag gtagttatat gctggagaag aaaaatcctc tagacacatg   7200

aaggcccaca tagtcaagtc ttccagggca aagccagcag cccacccagg tcaggtagcc   7260

agcagggctc agttcccctc actccagaca cggaccctcc tcttcagggt ctcttgaccc   7320

agcttccttc tctcctttta cctgagagca cagacctctc tcagccagcc tgcccagacc   7380

acggggggct actcccatgt agtttgggga gcacttgatc tcagaaaagc tccattgtct   7440

gagcaaatgg gcagttgtgg agctcaagcc tttctcctgt gctcaagtcc cttccccaag   7500

caaggcttca acctcatcta cccaccatgt agttttctct ggccatttaa gtggggcggc   7560

agggacatgg ttgggccatg ccacaccagg gctggtgagg caaccagttt tgattttgac   7620

agagtggctg gaggaaaagt ggcaatcaag gtgctgcttg gtttgctctg agtgcaaatg   7680

gaaccaacag gtttctgctg caatctgtgt gttcccagtg ccaggtcaca ccaggagggg   7740

tggggcaggg ctaaccaagt ggtctctgaa ctcaccgagc gtctgcactt ggttgtgaag   7800

ttaatgggag tacagagagc gtctggcctt ggagaggggt tgagagcctc ctttttggtt   7860

cttcattcct gagctcttgc ctgcccacaa atctgacctc tttgaatggg gacgcagtcc   7920

ttcaacagag aagtttctat ggcaaagaag tttctattta gctctagatc cagcagagtc   7980

atccattcta actgccctga agtctagagc aggggaggga acccagaggc tggggatgag   8040

actaggcaga ccctggttac catatggaca aggacagggg aaagcacccc cttcctcaat   8100

ttctgaaagt tctatctttg ggttcgcagg actttgagga tgataaagaa catataggta   8160

ctagcttgtt gttgctggtc caaagcttcc acagccctga gaatttggct ttcgtggctg   8220

ctctggcagc tgagcgaagg gaggaaggca gccgctctgg tggggactct aggcaccttc   8280

cctgctgtcc acttggatag gcggtgagcc ccagggtact gagaggagcc tgagcattta   8340

cctgccatta gtgcctcttc cttcaggaga ctggcttgaa acgtgtgttc atgtgcgcgt   8400

gcacacacac acatgagcac ctgtatgtgt taatgaatag tttttcttgg ttaatgcttt   8460

ttaacttctg ttcctttccg taagtggatg attcaaaatt aacgtgactt ggctgggcgc   8520

agtggctcac acctgtaatc ccagcacttt gggaggccaa gggaggcgga tcacctgagg   8580

tcaggagttc gagaccagcc tgatcggcat ggtgaaaccc cgtttctact aaaaatacaa   8640

aaattagccg ggcgtggtgg tgcgcgcctg taatcccagc tactcaggag gctgaggaag   8700

gagaatcact tgaacccggg aggtggaggt tgcagtgagc tgagatcgtg ccactgcact   8760

ccagcctggg cgacagagcg aaactccgtc tcaaaaaaaa aaaaaaaact taatgtgact   8820

ggagttaaaa gtgaaatgtc aggttgttta gtcactgaat agagagctac aagtgcttgg   8880

tctttcccaa gaatcaaacc tgagtagaaa tacatttaaa agaaaaatct acatggtacc   8940

tatgaatcct gtaatttgtt tagggagatc ttgtcactca tccctggttc ctgcccatac   9000

tgtttggtct cgttcttgca gtttgcttgg aacagggcca gagccccaca tgagattgtc   9060

agcaggagtg aggagcgcca gtccctactc ctcagcaggg acccagcaca gcaatccggt   9120

tgttctcggt tagactgggt cggggccagg ggagaagcag tcacccctgt gtagagggtt   9180

cccgctgtgc ttctgagcag ttgctttgtt cagaagtgtt aggagggtca gattgtgcca   9240

taattgttat taaagagaaa acacgcccac cttcctttct cccctgctgg ccattgttca   9300

ttgagtttta ctgagggcag cctttgtgga agtcagggag gttgccaaag gcctgtagat   9360

gcctcctgac aaggtcttga ttcctggttt tctagcaccc atttgcattt tggtcttcag   9420

cacaaagcct tgttccctgt ggccggactt ctgggcaata agactgggga gtgactgttg   9480

agcagtctgc tgtcaggaga gatggctgaa aaggtgatca tcttggtgct aaacaagtaa   9540

gaggcaactg ccctgttttt gtttgttttg aggcacaatg aaactttagc caaactctgc   9600

aagagggtcc catctcctgc catggccagg tgtgagagac caaaccgaga aaacagcata   9660

ctctatcact taagccttgg gtagaatggg aattctttac cctgggtaaa cgttttaaca   9720

aaaaaatgga acttaacttc ggtttggact gtggtcgtgc tgaggcagga gtggggttgc   9780

cctcttgggg ctgaatctcc aggcctcacg aggtcccctg tggggatgct gctatttcta   9840

agatgcaaat tgcacatttc ctagattttg tatctgtgga tttggataag ggaggggaac   9900

acggacaaat tgcttgtaca atttgaaatg ggcctcaatg gtacttcaaa ccttttgatt   9960

attcctaaat aaaaacataa atatatttca c                                  9991


<210>  1269
<211>  956
<212>  PRT
<213>  Homo sapiens

<400>  1269

Met Ala Ser Lys Arg Lys Ser Thr Thr Pro Cys Met Ile Pro Val Lys 
1               5                   10                  15


Thr Val Val Leu Gln Asp Ala Ser Met Glu Ala Gln Pro Ala Glu Thr 
            20                  25                  30


Leu Pro Glu Gly Pro Gln Gln Asp Leu Pro Pro Glu Ala Ser Ala Ala 
        35                  40                  45


Ser Ser Glu Ala Ala Gln Asn Pro Ser Ser Thr Asp Gly Ser Thr Leu 
    50                  55                  60


Ala Asn Gly His Arg Ser Thr Leu Asp Gly Tyr Leu Tyr Ser Cys Lys 
65                  70                  75                  80


Tyr Cys Asp Phe Arg Ser His Asp Met Thr Gln Phe Val Gly His Met 
                85                  90                  95


Asn Ser Glu His Thr Asp Phe Asn Lys Asp Pro Thr Phe Val Cys Ser 
            100                 105                 110


Gly Cys Ser Phe Leu Ala Lys Thr Pro Glu Gly Leu Ser Leu His Asn 
        115                 120                 125


Ala Thr Cys His Ser Gly Glu Ala Ser Phe Val Trp Asn Val Ala Lys 
    130                 135                 140


Pro Asp Asn His Val Val Val Glu Gln Ser Ile Pro Glu Ser Thr Ser 
145                 150                 155                 160


Thr Pro Asp Leu Ala Gly Glu Pro Ser Ala Glu Gly Ala Asp Gly Gln 
                165                 170                 175


Ala Glu Ile Ile Ile Thr Lys Thr Pro Ile Met Lys Ile Met Lys Gly 
            180                 185                 190


Lys Ala Glu Ala Lys Lys Ile His Thr Leu Lys Glu Asn Val Pro Ser 
        195                 200                 205


Gln Pro Val Gly Glu Ala Leu Pro Lys Leu Ser Thr Gly Glu Met Glu 
    210                 215                 220


Val Arg Glu Gly Asp His Ser Phe Ile Asn Gly Ala Val Pro Val Ser 
225                 230                 235                 240


Gln Ala Ser Ala Ser Ser Ala Lys Asn Pro His Ala Ala Asn Gly Pro 
                245                 250                 255


Leu Ile Gly Thr Val Pro Val Leu Pro Ala Gly Ile Ala Gln Phe Leu 
            260                 265                 270


Ser Leu Gln Gln Gln Pro Pro Val His Ala Gln His His Val His Gln 
        275                 280                 285


Pro Leu Pro Thr Ala Lys Ala Leu Pro Lys Val Met Ile Pro Leu Ser 
    290                 295                 300


Ser Ile Pro Thr Tyr Asn Ala Ala Met Asp Ser Asn Ser Phe Leu Lys 
305                 310                 315                 320


Asn Ser Phe His Lys Phe Pro Tyr Pro Thr Lys Ala Glu Leu Cys Tyr 
                325                 330                 335


Leu Thr Val Val Thr Lys Tyr Pro Glu Glu Gln Leu Lys Ile Trp Phe 
            340                 345                 350


Thr Ala Gln Arg Leu Lys Gln Gly Ile Ser Trp Ser Pro Glu Glu Ile 
        355                 360                 365


Glu Asp Ala Arg Lys Lys Met Phe Asn Thr Val Ile Gln Ser Val Pro 
    370                 375                 380


Gln Pro Thr Ile Thr Val Leu Asn Thr Pro Leu Val Ala Ser Ala Gly 
385                 390                 395                 400


Asn Val Gln His Leu Ile Gln Ala Ala Leu Pro Gly His Val Val Gly 
                405                 410                 415


Gln Pro Glu Gly Thr Gly Gly Gly Leu Leu Val Thr Gln Pro Leu Met 
            420                 425                 430


Ala Asn Gly Leu Gln Ala Thr Ser Ser Pro Leu Pro Leu Thr Val Thr 
        435                 440                 445


Ser Val Pro Lys Gln Pro Gly Val Ala Pro Ile Asn Thr Val Cys Ser 
    450                 455                 460


Asn Thr Thr Ser Ala Val Lys Val Val Asn Ala Ala Gln Ser Leu Leu 
465                 470                 475                 480


Thr Ala Cys Pro Ser Ile Thr Ser Gln Ala Phe Leu Asp Ala Ser Ile 
                485                 490                 495


Tyr Lys Asn Lys Lys Ser His Glu Gln Leu Ser Ala Leu Lys Gly Ser 
            500                 505                 510


Phe Cys Arg Asn Gln Phe Pro Gly Gln Ser Glu Val Glu His Leu Thr 
        515                 520                 525


Lys Val Thr Gly Leu Ser Thr Arg Glu Val Arg Lys Trp Phe Ser Asp 
    530                 535                 540


Arg Arg Tyr His Cys Arg Asn Leu Lys Gly Ser Arg Ala Met Ile Pro 
545                 550                 555                 560


Gly Asp His Ser Ser Ile Ile Ile Asp Ser Val Pro Glu Val Ser Phe 
                565                 570                 575


Ser Pro Ser Ser Lys Val Pro Glu Val Thr Cys Ile Pro Thr Thr Ala 
            580                 585                 590


Thr Leu Ala Thr His Pro Ser Ala Lys Arg Gln Ser Trp His Gln Thr 
        595                 600                 605


Pro Asp Phe Thr Pro Thr Lys Tyr Lys Glu Arg Ala Pro Glu Gln Leu 
    610                 615                 620


Arg Ala Leu Glu Ser Ser Phe Ala Gln Asn Pro Leu Pro Leu Asp Glu 
625                 630                 635                 640


Glu Leu Asp Arg Leu Arg Ser Glu Thr Lys Met Thr Arg Arg Glu Ile 
                645                 650                 655


Asp Ser Trp Phe Ser Glu Arg Arg Lys Lys Val Asn Ala Glu Glu Thr 
            660                 665                 670


Lys Lys Ala Glu Glu Asn Ala Ser Gln Glu Glu Glu Glu Ala Ala Glu 
        675                 680                 685


Asp Glu Gly Gly Glu Glu Asp Leu Ala Ser Glu Leu Arg Val Ser Gly 
    690                 695                 700


Glu Asn Gly Ser Leu Glu Met Pro Ser Ser His Ile Leu Ala Glu Arg 
705                 710                 715                 720


Lys Val Ser Pro Ile Lys Ile Asn Leu Lys Asn Leu Arg Val Thr Glu 
                725                 730                 735


Ala Asn Gly Arg Asn Glu Ile Pro Gly Leu Gly Ala Cys Asp Pro Glu 
            740                 745                 750


Asp Asp Glu Ser Asn Lys Leu Ala Glu Gln Leu Pro Gly Lys Val Ser 
        755                 760                 765


Cys Lys Lys Thr Ala Gln Gln Arg His Leu Leu Arg Gln Leu Phe Val 
    770                 775                 780


Gln Thr Gln Trp Pro Ser Asn Gln Asp Tyr Asp Ser Ile Met Ala Gln 
785                 790                 795                 800


Thr Gly Leu Pro Arg Pro Glu Val Val Arg Trp Phe Gly Asp Ser Arg 
                805                 810                 815


Tyr Ala Leu Lys Asn Gly Gln Leu Lys Trp Tyr Glu Asp Tyr Lys Arg 
            820                 825                 830


Gly Asn Phe Pro Pro Gly Leu Leu Val Ile Ala Pro Gly Asn Arg Glu 
        835                 840                 845


Leu Leu Gln Asp Tyr Tyr Met Thr His Lys Met Leu Tyr Glu Glu Asp 
    850                 855                 860


Leu Gln Asn Leu Cys Asp Lys Thr Gln Met Ser Ser Gln Gln Val Lys 
865                 870                 875                 880


Gln Trp Phe Ala Glu Lys Met Gly Glu Glu Thr Arg Ala Val Ala Asp 
                885                 890                 895


Thr Gly Ser Glu Asp Gln Gly Pro Gly Thr Gly Glu Leu Thr Ala Val 
            900                 905                 910


His Lys Gly Met Gly Asp Thr Tyr Ser Glu Val Ser Glu Asn Ser Glu 
        915                 920                 925


Ser Trp Glu Pro Arg Val Pro Glu Ala Ser Ser Glu Pro Phe Asp Thr 
    930                 935                 940


Ser Ser Pro Gln Ala Gly Arg Gln Leu Glu Thr Asp 
945                 950                 955


<210>  1270
<211>  4464
<212>  DNA
<213>  Homo sapiens

<400>  1270
cgaagacact cacctgtgga gcctgtgcac gtaggtagag gcggcggctc tgagtccagg     60

agctccagtg ggcagctccc cagcaccagc catgaactac gtggggcagc tggcggagac    120

ggtgtttggg acggtgaagg agctgtaccg gggcctgaac ccagccacac tgagcggcgg    180

cattgacgtg ctggtggtga agcaggtgga cggctcgttc cggtgctcac ccttccacgt    240

gcgttttggc aagctgggcg tcctgcggtc gcgggagaag gtggtagaca ttgagctcaa    300

tggggagcct gtggacttgc acatgaagct tggggacagc ggggaggcct tctttgttca    360

ggagctggag agcgatgatg aacatgtgcc tcccggcctg tgcacctcac ccatcccttg    420

ggggggtctg tctggcttcc cctcggactc ccagctgggc actgccagtg agcctgaggg    480

cctcgtcatg gcaggcacgg cctccactgg gcggaggaag aggcgtcgca ggaggaaacc    540

caagcagaaa gaggatgcag tggcaactga ttctagtcca gaggaactgg aggcaggcgc    600

tgagagtgag ctatccctgc cggaaaagct gaggccagag cccccaggtg tccagttgga    660

agagaagtct tcactgcagc ccaaagacat ctacccctac tcggatggcg agtggccccc    720

ccaggccagc ctctcagcag gtgagctaac atcccctaag agcgactcgg agctggaggt    780

gcggaccccg gagcccagtc ccctaagagc cgagtcccac atgcagtggg cctgggggag    840

gctgcctaag gtggccagag ctgagcggcc cgagtcctca gtggtccttg aaggcagagc    900

tggggcaacc tctcctcctc ggggaggacc cagcactccc tctacctctg tggctggcgg    960

cgtggaccct ttgggactcc caatccagca aacagaggct ggtgccgacc ttcagcctga   1020

cacagaggat cccactctag tgggtccccc tctccacacc ccagagacag aggaaagcaa   1080

gactcagagc tctggggaca tgggcctccc tcctgcctcc aagtcatgga gctgggccac   1140

tctggaggtt ccagttccca ccgggcagcc agagagggtc tccaggggga aaggctcccc   1200

aaagagaagc cagcacctgg gccccagtga catctacctg gatgacttgc cctccctgga   1260

ctctgagaat gcagcgcttt acttccccca aagtgactct gggctggggg ccagaagatg   1320

gagtgaaccc agcagtcaga agtccctgag ggaccccaac cctgaacatg aacctgaacc   1380

cactctggac acagtggata caatagcact gtccctctgt ggtggactgg ctgacagccg   1440

ggacatctcc ctagagaaat tcaaccagca cagcgtctct taccaggacc tcaccaaaaa   1500

ccccggactt ttggatgacc caaacctagt ggtgaaaatc aatggaaagc attataactg   1560

ggctgtggct gcccccatga tcctctccct gcaagccttc cagaaaaact tgcccaagag   1620

caccatggac aagctggaga gggagaagat gccccggaag ggtgggcgat ggtggttttc   1680

ctggcgacgc agggacttcc tggccgagga gcgcagtgcc cagaaggaga agactgcagc   1740

caaggagcag cagggggaga agacagaagt cctgagcagt gatgacgatg ccccagacag   1800

ccctgtgatc ctggagatcc cctccttgcc accctccact ccaccctcca ctcctaccta   1860

caagaagtcc ctccgcctct cctccgatca gatccggcgc ctgaacctgc aagaaggtgc   1920

caatgatgtg gtcttcagcg tgaccactca gtaccagggc acctgccgct gcaaggccac   1980

catctacctg tggaaatggg acgacaaggt ggtcatctct gacatcgacg gcaccatcac   2040

caagtcagat gctctgggcc atatcctgcc ccagctgggg aaagactgga cacaccaggg   2100

catcaccagt ctctatcaca aaatccaact aaatgggtac aagttcctgt actgctcggc   2160

gcgggccatt ggcatggcgg acctcaccaa ggggtacctg cagtgggtga gcgagggggg   2220

ctgtagcctc cccaagggcc ccatccttct gtctcccagc agcctcttct ctgccctcca   2280

cagagaggtg atcgagaaga aaccagaggt gttcaaggtc gcctgcctga gtgacatcca   2340

gcagctgttt ctgccccacg gacagccctt ctatgctgcc tttgggaata ggcccaatga   2400

tgtctttgcc taccggcagg tgggcctgcc tgagtcacgc atcttcacag tcaacccccg   2460

gggagagctc atccaggagc tcataaagaa ccacaaatcc acgtatgagc ggcttggtga   2520

agtggtcgag ctcctcttcc cacctgtggc ccgtggcccc agcacagacc tggccaaccc   2580

tgaatacagt aacttctgct actggcggga gccactgcct gctgtggacc ttgataccct   2640

ggactgaacc tgccctggct ggctcctcct ccctggcccg gcccaggact ggctaggtgt   2700

cctggggtat aggagggtgg gaattggagt gtcatggggc aaacccactg aaggggaagg   2760

aggaggctgc aggttggttg gcagctagag agactccccc atcttccccg tcatattttt   2820

gccagctaag ctgcagctgc tccaggcgtc agtgtggcac tgtcctgggg caattagctt   2880

gtcatctggg cccttgcagg gttctttttt tttttttttt tttttttttc ctgagacagg   2940

gtcttgttct gttgcccagg ctggagtgca gtggcatgat ctctcggctc actgcaacct   3000

ccgcctcccg ggttcaagcg attcacctgc ctcagcctcc caagtagctg ggattacagg   3060

cgtgtaccac cacgcctggc taattttcgt gtttttagta gagatgggtt ttcaccacat   3120

tggccaggct ggtctcgaac tcctgacctc aagtgatttg cccacctcgg cctcccaaag   3180

tgctgggatt acaggcatga gctaccatgc caggcctcct tgcagggttt tctatgccct   3240

tgatatctgt ctccctgtca acctgggacc ttgctgtaag tcttgatagg acagggagaa   3300

gagggaggcc ctaccgaggc tcgaggcttc agtgaagggt gacagcagtg ggagtgtggt   3360

acagcctctg gaaggacaca gtgttctccc cgccccttgt ctgggagcca ggactgtacc   3420

ctccgaagcc agacatcact gccaacatat cccccttgct ggtgccctgg catctcagca   3480

catgacacac acccacacct gcaggctgtg gttccggctt ggcctgctcc ccgtccggct   3540

gctgccgctg cctctctcca gacctcgctt aaggacagtc ccaaactcag ctggggcagg   3600

tgttggcctg aaagtcctcc cccagcctct gctggccagc ttggtgctca cagctgctgg   3660

gtaagctctt gcctaaggag ctgtgggaag cagggctgat gccccagcaa cctctcctcc   3720

cactgtcttt gaagaaagta gctttagacc ggctaaaagc tttaatccag agcctgccct   3780

actctgatag taccagagtg gagggcagaa taccaaatgt ccaggaacca aaggcagggc   3840

tgtggggacc tgaagagcgg cacagtgggg cccgtgctgc tgtgggggaa actgaggctg   3900

ggagcctcag cagagaccgg tgtcaagagt ctctgggaac tgcataggcc tgaggaacat   3960

gcattttcaa gttgtccatt gatggtttcg tacctgaatt tctcaccttt tgtgaacatc   4020

ttgggagggt gggggttttg caggggtgtt aaaagcaagg cttggagccc ctttcctcca   4080

gctggtggct ccttctcagg gcctggcctc attcaggcca ctttgtagag aaatgccctg   4140

acctcgcagg aaggatttcc ccacccccaa gtggaaggaa gaggacagtg tgggcaccag   4200

agggccctgg aaacatctta ggggaaggaa aggaaaagga taaatttgga gtggggggtc   4260

tctaaacaga ttgcctggat tccgttcttt cctggggttc tacagctgcc taagccctca   4320

ccttggggga ggatcaaagg gaataaagag aactcttggc tgaaaaaaaa aaaaaaaaaa   4380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   4440

aaaaaaaaaa aaaaaaaaaa aaaa                                          4464


<210>  1271
<211>  851
<212>  PRT
<213>  Homo sapiens

<400>  1271

Met Asn Tyr Val Gly Gln Leu Ala Glu Thr Val Phe Gly Thr Val Lys 
1               5                   10                  15


Glu Leu Tyr Arg Gly Leu Asn Pro Ala Thr Leu Ser Gly Gly Ile Asp 
            20                  25                  30


Val Leu Val Val Lys Gln Val Asp Gly Ser Phe Arg Cys Ser Pro Phe 
        35                  40                  45


His Val Arg Phe Gly Lys Leu Gly Val Leu Arg Ser Arg Glu Lys Val 
    50                  55                  60


Val Asp Ile Glu Leu Asn Gly Glu Pro Val Asp Leu His Met Lys Leu 
65                  70                  75                  80


Gly Asp Ser Gly Glu Ala Phe Phe Val Gln Glu Leu Glu Ser Asp Asp 
                85                  90                  95


Glu His Val Pro Pro Gly Leu Cys Thr Ser Pro Ile Pro Trp Gly Gly 
            100                 105                 110


Leu Ser Gly Phe Pro Ser Asp Ser Gln Leu Gly Thr Ala Ser Glu Pro 
        115                 120                 125


Glu Gly Leu Val Met Ala Gly Thr Ala Ser Thr Gly Arg Arg Lys Arg 
    130                 135                 140


Arg Arg Arg Arg Lys Pro Lys Gln Lys Glu Asp Ala Val Ala Thr Asp 
145                 150                 155                 160


Ser Ser Pro Glu Glu Leu Glu Ala Gly Ala Glu Ser Glu Leu Ser Leu 
                165                 170                 175


Pro Glu Lys Leu Arg Pro Glu Pro Pro Gly Val Gln Leu Glu Glu Lys 
            180                 185                 190


Ser Ser Leu Gln Pro Lys Asp Ile Tyr Pro Tyr Ser Asp Gly Glu Trp 
        195                 200                 205


Pro Pro Gln Ala Ser Leu Ser Ala Gly Glu Leu Thr Ser Pro Lys Ser 
    210                 215                 220


Asp Ser Glu Leu Glu Val Arg Thr Pro Glu Pro Ser Pro Leu Arg Ala 
225                 230                 235                 240


Glu Ser His Met Gln Trp Ala Trp Gly Arg Leu Pro Lys Val Ala Arg 
                245                 250                 255


Ala Glu Arg Pro Glu Ser Ser Val Val Leu Glu Gly Arg Ala Gly Ala 
            260                 265                 270


Thr Ser Pro Pro Arg Gly Gly Pro Ser Thr Pro Ser Thr Ser Val Ala 
        275                 280                 285


Gly Gly Val Asp Pro Leu Gly Leu Pro Ile Gln Gln Thr Glu Ala Gly 
    290                 295                 300


Ala Asp Leu Gln Pro Asp Thr Glu Asp Pro Thr Leu Val Gly Pro Pro 
305                 310                 315                 320


Leu His Thr Pro Glu Thr Glu Glu Ser Lys Thr Gln Ser Ser Gly Asp 
                325                 330                 335


Met Gly Leu Pro Pro Ala Ser Lys Ser Trp Ser Trp Ala Thr Leu Glu 
            340                 345                 350


Val Pro Val Pro Thr Gly Gln Pro Glu Arg Val Ser Arg Gly Lys Gly 
        355                 360                 365


Ser Pro Lys Arg Ser Gln His Leu Gly Pro Ser Asp Ile Tyr Leu Asp 
    370                 375                 380


Asp Leu Pro Ser Leu Asp Ser Glu Asn Ala Ala Leu Tyr Phe Pro Gln 
385                 390                 395                 400


Ser Asp Ser Gly Leu Gly Ala Arg Arg Trp Ser Glu Pro Ser Ser Gln 
                405                 410                 415


Lys Ser Leu Arg Asp Pro Asn Pro Glu His Glu Pro Glu Pro Thr Leu 
            420                 425                 430


Asp Thr Val Asp Thr Ile Ala Leu Ser Leu Cys Gly Gly Leu Ala Asp 
        435                 440                 445


Ser Arg Asp Ile Ser Leu Glu Lys Phe Asn Gln His Ser Val Ser Tyr 
    450                 455                 460


Gln Asp Leu Thr Lys Asn Pro Gly Leu Leu Asp Asp Pro Asn Leu Val 
465                 470                 475                 480


Val Lys Ile Asn Gly Lys His Tyr Asn Trp Ala Val Ala Ala Pro Met 
                485                 490                 495


Ile Leu Ser Leu Gln Ala Phe Gln Lys Asn Leu Pro Lys Ser Thr Met 
            500                 505                 510


Asp Lys Leu Glu Arg Glu Lys Met Pro Arg Lys Gly Gly Arg Trp Trp 
        515                 520                 525


Phe Ser Trp Arg Arg Arg Asp Phe Leu Ala Glu Glu Arg Ser Ala Gln 
    530                 535                 540


Lys Glu Lys Thr Ala Ala Lys Glu Gln Gln Gly Glu Lys Thr Glu Val 
545                 550                 555                 560


Leu Ser Ser Asp Asp Asp Ala Pro Asp Ser Pro Val Ile Leu Glu Ile 
                565                 570                 575


Pro Ser Leu Pro Pro Ser Thr Pro Pro Ser Thr Pro Thr Tyr Lys Lys 
            580                 585                 590


Ser Leu Arg Leu Ser Ser Asp Gln Ile Arg Arg Leu Asn Leu Gln Glu 
        595                 600                 605


Gly Ala Asn Asp Val Val Phe Ser Val Thr Thr Gln Tyr Gln Gly Thr 
    610                 615                 620


Cys Arg Cys Lys Ala Thr Ile Tyr Leu Trp Lys Trp Asp Asp Lys Val 
625                 630                 635                 640


Val Ile Ser Asp Ile Asp Gly Thr Ile Thr Lys Ser Asp Ala Leu Gly 
                645                 650                 655


His Ile Leu Pro Gln Leu Gly Lys Asp Trp Thr His Gln Gly Ile Thr 
            660                 665                 670


Ser Leu Tyr His Lys Ile Gln Leu Asn Gly Tyr Lys Phe Leu Tyr Cys 
        675                 680                 685


Ser Ala Arg Ala Ile Gly Met Ala Asp Leu Thr Lys Gly Tyr Leu Gln 
    690                 695                 700


Trp Val Ser Glu Gly Gly Cys Ser Leu Pro Lys Gly Pro Ile Leu Leu 
705                 710                 715                 720


Ser Pro Ser Ser Leu Phe Ser Ala Leu His Arg Glu Val Ile Glu Lys 
                725                 730                 735


Lys Pro Glu Val Phe Lys Val Ala Cys Leu Ser Asp Ile Gln Gln Leu 
            740                 745                 750


Phe Leu Pro His Gly Gln Pro Phe Tyr Ala Ala Phe Gly Asn Arg Pro 
        755                 760                 765


Asn Asp Val Phe Ala Tyr Arg Gln Val Gly Leu Pro Glu Ser Arg Ile 
    770                 775                 780


Phe Thr Val Asn Pro Arg Gly Glu Leu Ile Gln Glu Leu Ile Lys Asn 
785                 790                 795                 800


His Lys Ser Thr Tyr Glu Arg Leu Gly Glu Val Val Glu Leu Leu Phe 
                805                 810                 815


Pro Pro Val Ala Arg Gly Pro Ser Thr Asp Leu Ala Asn Pro Glu Tyr 
            820                 825                 830


Ser Asn Phe Cys Tyr Trp Arg Glu Pro Leu Pro Ala Val Asp Leu Asp 
        835                 840                 845


Thr Leu Asp 
    850


<210>  1272
<211>  3827
<212>  DNA
<213>  Homo sapiens

<400>  1272
cgcctcccct ccgcggcccc agccgctagc agcgccggcc actccgcggg acgcagccgc     60

cgcgaagcgc caggcggccg ggccagcgag ctcgggggcc gaaggggacc ccgggaccct    120

cggggcggga cccgggccga ccagcggcgg gggcggcgcg gcgctgcagg cggacacccg    180

gcggggggca ccgcgcgggg ccgggcagag gcgcgggggc cgctatgggc cgccgccgcc    240

tgctcgtctg gctgtgcgcc gtcgcggcgc tgctctcggg ggcgcaggcc aggggcaccc    300

cgctcctggc gcggcctgcg ccgcccggtg cctcccgcta cagtctctac acgacgggat    360

ggcgcccgcg gctgcgcccg gggccgcaca aggccctctg tgcctatgtg gtgcacagga    420

atgtgacctg catcctacag gagggagcgg agagctacgt aaaggctgaa taccggcagt    480

gtagatgggg gcccaagtgc cccgggacag tcacgtaccg cacagtactc agacccaaat    540

acaaggttgg ctacaagaca gtgacagacc tcgcctggcg ttgctgtccc ggcttcactg    600

ggaaacgctg ccctgagcac ctcacggacc atggggctgc ctcaccccag ctggagcctg    660

agcctcagat tccttcaggg cagctggacc caggccccag gcccccttcc tacagcagag    720

cagcccccag ccctcatgga aggaaaggcc cagggctgtt tggtgagcgg ctggaacgcc    780

tggagggtga tgtccagcgc ctggctcaaa catatggtac cctcagtggc ctggtggcta    840

gccacgagga tcccaacagg atgactggtg gccccagggc tcctgctgtc cctgtgggct    900

ttggggtcat ccctgagggg cttgtgggcc caggagacag agccagaggg ccactaacac    960

ctcccttaga cgagatccta agcaaggtga cagaggtgag caacactctt cagaccaagg   1020

tgcagcttct agacaaggtg catgggctgg cacttggcca tgaggcccac ctgcagcggc   1080

tgcgggaagc cccaccatcc ccgctcacct ccctggccct gctggaggag tacgtggacc   1140

gacggctgca ccgactctgg gggagcctgc tggatggctt tgagcagaag ctgcaaggcg   1200

tccagagtga gtgtgacctg cgggtgcagg aggtacggcg gcaatgtgag gagggtcagg   1260

ccgccagccg gaggctgcac cagagccttg atggccggga gctggccctg cgccaggagc   1320

tgtcacagct gggcagccag ctgcagggcc tgagcgtgtc tggcaggggc agctgctgtg   1380

ggcaactagc cttgatcaat gcccgtatgg atggccttga gagggccctg caggcagtca   1440

ccgagaccca aaggggcccc ggtgccccgg ccggggatga gcttacgagg ctctctgctg   1500

ccatgctcga gggaggtgtg gacgggctgc ttgagggtct ggagacgctc aatgggacag   1560

agggtggagc aaggggatgc tgtctgaggt tggacatggg ggggtgggga gtgggcggct   1620

ttgggaccat gctggaagag cgcgtgcaga gcctcgagga gcgcctagca acattggctg   1680

gggagctaag ccatgacagc gcctctccgg gcaggtcagc tcggcccctt gtacagacag   1740

agctggctgt gctagagcaa cggttggtct cactggagac ttcgtgcacc ccgagcacca   1800

cctcagccat cctggacagc ctcgtggcag aggtgaaggc ctggcagagc cggagcgagg   1860

ccctcctacg ccaggtggcc agccacgcag cactgctcca gcagctcaat ggcactgtgg   1920

ccgaggtcca gggacagctg gcagaaggga cgggcagctc acttcaaggc gagatcactc   1980

tgctcaaggt caatctgaac tcagtgagca agtcgctcac aggcctcagt gactctgtca   2040

gccagtactc tgatgccttc ttggctgcca acacgtccct ggatgagcgg gaacgcaagg   2100

tggaagccga agtccaggcc atccaggagc aggtcagcag ccaaggctcc aggcttcagg   2160

ctggccacag gcaggtcctg aacctgcgtg gggagctgga gcaactcaag gctggtgtgg   2220

ccaaggtggc cagtgggctg agccgctgcc aggacacagc ccagaaactt cagcacacag   2280

tgggacactt tgaccagcgg gtggcacaag tggagggtgc gtgcaggagg ctgggcctgc   2340

tggccgcggg cctggacagc ttgcccactg agccactgag gcccagagag ggcctgtgga   2400

gccatgtgga ccagctgaat cgtacgctgg cccagcacac gcaggacatt gcccgcctcc   2460

gggatgacct actggactgc caggcccagc tggctgagca ggtgcggcca gggcaagcca   2520

actagacagg ctggccagga cccaacccct agatcccacc aactcgggga acatcacccc   2580

agagcccagc cttatccagc agcgccttcc agccttccct ggctagccca aatggcacta   2640

aggaggccac tgagggaatc ctccacgtgg ctgtcccagc caccaaaacc catgcacagt   2700

gctgcagaaa ctggacagtt ccggacagcg gtcaaggcaa ggatgtcatg cttgaaggcc   2760

agggtagact tgagagagtt cacattccac tgtcagcaaa tcagtgtctg gacagccagc   2820

tgcagggcct gagcatggct ggcaggggca gctgctgtgg caaactggcc ttgatcagtg   2880

tccgtatgta aggccttgag aggaccctgc aggcagtcag caccagcctc agcaactgtg   2940

cagagaccta caggcccaca gccagtggcc tgtccgcatt gccctgtgcc cacaagcaac   3000

agtccacagc ccttggtggc ttctgttcct tgtcccctcg gcttctcttc gcagccatca   3060

ggactaggtt tgtgcaggaa ggtgatgccc actggaactc tcctcacacc tggcagcttc   3120

atggatgttg tatctgaact aaggaccaga ggctgccaga tgtttctggc tcctcacgtg   3180

tccttcagga cagaacagaa gcacaaagac tcagccaaga gttctcttta ttccctttga   3240

tcctccccca aggtgagggc ttaggcagct gtagaacccc aggaaagaac ggaatccagg   3300

caatctgttt agagaccccc cactccaaat ttatcctttt cctttccttc ccctaagatg   3360

tttccagggc cctctggtgc ccacactgtc ctcttccttc cacttggggg tggggaaatc   3420

cttcctgcga ggtcagggca tttctctaca aagtggcctg aatgaggcca ggccctgaga   3480

aggagccacc agctggagga aaggggctcc aagccttgct tttaacaccc ctgcaaaacc   3540

cccaccctcc caagatgttc acaaaaggtg agaaattcag gtacgaaacc atcaatggac   3600

aacttgaaaa tgcatgttcc tcaggcctat gcagttccca gagactcttg acaccggtct   3660

ctgctgaggc tcccagcctc agtttccccc acagcagcac gggccccact gtgctgctct   3720

tcaggtcccc acagccctgc ctttggttcc tggacatttg gtattctgcc ctccactctg   3780

gtactatcag agtagggcag gctctggatt aaagctttta gccggtc                 3827


<210>  1273
<211>  766
<212>  PRT
<213>  Homo sapiens

<400>  1273

Met Gly Arg Arg Arg Leu Leu Val Trp Leu Cys Ala Val Ala Ala Leu 
1               5                   10                  15


Leu Ser Gly Ala Gln Ala Arg Gly Thr Pro Leu Leu Ala Arg Pro Ala 
            20                  25                  30


Pro Pro Gly Ala Ser Arg Tyr Ser Leu Tyr Thr Thr Gly Trp Arg Pro 
        35                  40                  45


Arg Leu Arg Pro Gly Pro His Lys Ala Leu Cys Ala Tyr Val Val His 
    50                  55                  60


Arg Asn Val Thr Cys Ile Leu Gln Glu Gly Ala Glu Ser Tyr Val Lys 
65                  70                  75                  80


Ala Glu Tyr Arg Gln Cys Arg Trp Gly Pro Lys Cys Pro Gly Thr Val 
                85                  90                  95


Thr Tyr Arg Thr Val Leu Arg Pro Lys Tyr Lys Val Gly Tyr Lys Thr 
            100                 105                 110


Val Thr Asp Leu Ala Trp Arg Cys Cys Pro Gly Phe Thr Gly Lys Arg 
        115                 120                 125


Cys Pro Glu His Leu Thr Asp His Gly Ala Ala Ser Pro Gln Leu Glu 
    130                 135                 140


Pro Glu Pro Gln Ile Pro Ser Gly Gln Leu Asp Pro Gly Pro Arg Pro 
145                 150                 155                 160


Pro Ser Tyr Ser Arg Ala Ala Pro Ser Pro His Gly Arg Lys Gly Pro 
                165                 170                 175


Gly Leu Phe Gly Glu Arg Leu Glu Arg Leu Glu Gly Asp Val Gln Arg 
            180                 185                 190


Leu Ala Gln Thr Tyr Gly Thr Leu Ser Gly Leu Val Ala Ser His Glu 
        195                 200                 205


Asp Pro Asn Arg Met Thr Gly Gly Pro Arg Ala Pro Ala Val Pro Val 
    210                 215                 220


Gly Phe Gly Val Ile Pro Glu Gly Leu Val Gly Pro Gly Asp Arg Ala 
225                 230                 235                 240


Arg Gly Pro Leu Thr Pro Pro Leu Asp Glu Ile Leu Ser Lys Val Thr 
                245                 250                 255


Glu Val Ser Asn Thr Leu Gln Thr Lys Val Gln Leu Leu Asp Lys Val 
            260                 265                 270


His Gly Leu Ala Leu Gly His Glu Ala His Leu Gln Arg Leu Arg Glu 
        275                 280                 285


Ala Pro Pro Ser Pro Leu Thr Ser Leu Ala Leu Leu Glu Glu Tyr Val 
    290                 295                 300


Asp Arg Arg Leu His Arg Leu Trp Gly Ser Leu Leu Asp Gly Phe Glu 
305                 310                 315                 320


Gln Lys Leu Gln Gly Val Gln Ser Glu Cys Asp Leu Arg Val Gln Glu 
                325                 330                 335


Val Arg Arg Gln Cys Glu Glu Gly Gln Ala Ala Ser Arg Arg Leu His 
            340                 345                 350


Gln Ser Leu Asp Gly Arg Glu Leu Ala Leu Arg Gln Glu Leu Ser Gln 
        355                 360                 365


Leu Gly Ser Gln Leu Gln Gly Leu Ser Val Ser Gly Arg Gly Ser Cys 
    370                 375                 380


Cys Gly Gln Leu Ala Leu Ile Asn Ala Arg Met Asp Gly Leu Glu Arg 
385                 390                 395                 400


Ala Leu Gln Ala Val Thr Glu Thr Gln Arg Gly Pro Gly Ala Pro Ala 
                405                 410                 415


Gly Asp Glu Leu Thr Arg Leu Ser Ala Ala Met Leu Glu Gly Gly Val 
            420                 425                 430


Asp Gly Leu Leu Glu Gly Leu Glu Thr Leu Asn Gly Thr Glu Gly Gly 
        435                 440                 445


Ala Arg Gly Cys Cys Leu Arg Leu Asp Met Gly Gly Trp Gly Val Gly 
    450                 455                 460


Gly Phe Gly Thr Met Leu Glu Glu Arg Val Gln Ser Leu Glu Glu Arg 
465                 470                 475                 480


Leu Ala Thr Leu Ala Gly Glu Leu Ser His Asp Ser Ala Ser Pro Gly 
                485                 490                 495


Arg Ser Ala Arg Pro Leu Val Gln Thr Glu Leu Ala Val Leu Glu Gln 
            500                 505                 510


Arg Leu Val Ser Leu Glu Thr Ser Cys Thr Pro Ser Thr Thr Ser Ala 
        515                 520                 525


Ile Leu Asp Ser Leu Val Ala Glu Val Lys Ala Trp Gln Ser Arg Ser 
    530                 535                 540


Glu Ala Leu Leu Arg Gln Val Ala Ser His Ala Ala Leu Leu Gln Gln 
545                 550                 555                 560


Leu Asn Gly Thr Val Ala Glu Val Gln Gly Gln Leu Ala Glu Gly Thr 
                565                 570                 575


Gly Ser Ser Leu Gln Gly Glu Ile Thr Leu Leu Lys Val Asn Leu Asn 
            580                 585                 590


Ser Val Ser Lys Ser Leu Thr Gly Leu Ser Asp Ser Val Ser Gln Tyr 
        595                 600                 605


Ser Asp Ala Phe Leu Ala Ala Asn Thr Ser Leu Asp Glu Arg Glu Arg 
    610                 615                 620


Lys Val Glu Ala Glu Val Gln Ala Ile Gln Glu Gln Val Ser Ser Gln 
625                 630                 635                 640


Gly Ser Arg Leu Gln Ala Gly His Arg Gln Val Leu Asn Leu Arg Gly 
                645                 650                 655


Glu Leu Glu Gln Leu Lys Ala Gly Val Ala Lys Val Ala Ser Gly Leu 
            660                 665                 670


Ser Arg Cys Gln Asp Thr Ala Gln Lys Leu Gln His Thr Val Gly His 
        675                 680                 685


Phe Asp Gln Arg Val Ala Gln Val Glu Gly Ala Cys Arg Arg Leu Gly 
    690                 695                 700


Leu Leu Ala Ala Gly Leu Asp Ser Leu Pro Thr Glu Pro Leu Arg Pro 
705                 710                 715                 720


Arg Glu Gly Leu Trp Ser His Val Asp Gln Leu Asn Arg Thr Leu Ala 
                725                 730                 735


Gln His Thr Gln Asp Ile Ala Arg Leu Arg Asp Asp Leu Leu Asp Cys 
            740                 745                 750


Gln Ala Gln Leu Ala Glu Gln Val Arg Pro Gly Gln Ala Asn 
        755                 760                 765


<210>  1274
<211>  7923
<212>  DNA
<213>  Homo sapiens

<400>  1274
agcgacggcg gcggctgcgg cttagtcggt ggcggccggc ggcggctgcg ggctgagcgg     60

cgagtttccg atttaaagct gagctgcgag gaaaatggcg gcgggaggat caaaatactt    120

gctggatggt ggactcagag accaataaaa ataaactgct tgaacatcct ttgactggtt    180

agccagttgc tgatgtatat tcaagatgag tggattagga gaaaacttgg atccactggc    240

cagtgattca cgaaaacgca aattgccatg tgatactcca ggacaaggtc ttacctgcag    300

tggtgaaaaa cggagacggg agcaggaaag taaatatatt gaagaattgg ctgagctgat    360

atctgccaat cttagtgata ttgacaattt caatgtcaaa ccagataaat gtgcgatttt    420

aaaggaaaca gtaagacaga tacgtcaaat aaaagagcaa ggaaaaacta tttccaatga    480

tgatgatgtt caaaaagccg atgtatcttc tacagggcag ggagttattg ataaagactc    540

cttaggaccg cttttacttc aggcattgga tggtttccta tttgtggtga atcgagacgg    600

aaacattgta tttgtatcag aaaatgtcac acaatacctg caatataagc aagaggacct    660

ggttaacaca agtgtttaca atatcttaca tgaagaagac agaaaggatt ttcttaagaa    720

tttaccaaaa tctacagtta atggagtttc ctggacaaat gagacccaaa gacaaaaaag    780

ccatacattt aattgccgta tgttgatgaa aacaccacat gatattctgg aagacataaa    840

cgccagtcct gaaatgcgcc agagatatga aacaatgcag tgctttgccc tgtctcagcc    900

acgagctatg atggaggaag gggaagattt gcaatcttgt atgatctgtg tggcacgccg    960

cattactaca ggagaaagaa catttccatc aaaccctgag agctttatta ccagacatga   1020

tctttcagga aaggttgtca atatagatac aaattcactg agatcctcca tgaggcctgg   1080

ctttgaagat ataatccgaa ggtgtattca gagatttttt agtctaaatg atgggcagtc   1140

atggtcccag aaacgtcact atcaagaagc ttatcttaat ggccatgcag aaaccccagt   1200

atatcgattc tcgttggctg atggaactat agtgactgca cagacaaaaa gcaaactctt   1260

ccgaaatcct gtaacaaatg atcgacatgg ctttgtctca acccacttcc ttcagagaga   1320

acagaatgga tatagaccaa acccaaatcc tgttggacaa gggattagac cacctatggc   1380

tggatgcaac agttcggtag gcggcatgag tatgtcgcca aaccaaggct tacagatgcc   1440

gagcagcagg gcctatggct tggcagaccc tagcaccaca gggcagatga gtggagctag   1500

gtatgggggt tccagtaaca tagcttcatt gacccctggg ccaggcatgc aatcaccatc   1560

ttcctaccag aacaacaact atgggctcaa catgagtagc cccccacatg ggagtcctgg   1620

tcttgcccca aaccagcaga atatcatgat ttctcctcgt aatcgtggga gtccaaagat   1680

agcctcacat cagttttctc ctgttgcagg tgtgcactct cccatggcat cttctggcaa   1740

tactgggaac cacagctttt ccagcagctc tctcagtgcc ctgcaagcca tcagtgaagg   1800

tgtggggact tcccttttat ctactctgtc atcaccaggc cccaaattgg ataactctcc   1860

caatatgaat attacccaac caagtaaagt aagcaatcag gattccaaga gtcctctggg   1920

cttttattgc gaccaaaatc cagtggagag ttcaatgtgt cagtcaaata gcagagatca   1980

cctcagtgac aaagaaagta aggagagcag tgttgagggg gcagagaatc aaaggggtcc   2040

tttggaaagc aaaggtcata aaaaattact gcagttactt acctgttctt ctgatgaccg   2100

gggtcattcc tccttgacca actcccccct agattcaagt tgtaaagaat cttctgttag   2160

tgtcaccagc ccctctggag tctcctcctc tacatctgga ggagtatcct ctacatccaa   2220

tatgcatggg tcactgttac aagagaagca ccggattttg cacaagttgc tgcagaatgg   2280

gaattcacca gctgaggtag ccaagattac tgcagaagcc actgggaaag acaccagcag   2340

tataacttct tgtggggacg gaaatgttgt caagcaggag cagctaagtc ctaagaagaa   2400

ggagaataat gcacttctta gatacctgct ggacagggat gatcctagtg atgcactctc   2460

taaagaacta cagccccaag tggaaggagt ggataataaa atgagtcagt gcaccagctc   2520

caccattcct agctcaagtc aagagaaaga ccctaaaatt aagacagaga caagtgaaga   2580

gggatctgga gacttggata atctagatgc tattcttggt gatctgacta gttctgactt   2640

ttacaataat tccatatcct caaatggtag tcatctgggg actaagcaac aggtgtttca   2700

aggaactaat tctctgggtt tgaaaagttc acagtctgtg cagtctattc gtcctccata   2760

taaccgagca gtgtctctgg atagccctgt ttctgttggc tcaagtcctc cagtaaaaaa   2820

tatcagtgct ttccccatgt taccaaagca acccatgttg ggtgggaatc caagaatgat   2880

ggatagtcag gaaaattatg gctcaagtat gggtgggcca aaccgaaatg tgactgtgac   2940

tcagactcct tcctcaggag actggggctt accaaactca aaggccggca gaatggaacc   3000

tatgaattca aactccatgg gaagaccagg aggagattat aatacttctt tacccagacc   3060

tgcactgggt ggctctattc ccacattgcc tcttcggtct aatagcatac caggtgcgag   3120

accagtattg caacagcagc agcagatgct tcaaatgagg cctggtgaaa tccccatggg   3180

aatgggggct aatccctatg gccaagcagc agcatctaac caactgggtt cctggcccga   3240

tggcatgttg tccatggaac aagtttctca tggcactcaa aataggcctc ttcttaggaa   3300

ttccctggat gatcttgttg ggccaccttc caacctggaa ggccagagtg acgaaagagc   3360

attattggac cagctgcaca ctcttctcag caacacagat gccacaggcc tggaagaaat   3420

tgacagagct ttgggcattc ctgaacttgt caatcaggga caggcattag agcccaaaca   3480

ggatgctttc caaggccaag aagcagcagt aatgatggat cagaaggcag gattatatgg   3540

acagacatac ccagcacagg ggcctccaat gcaaggaggc tttcatcttc agggacaatc   3600

accatctttt aactctatga tgaatcagat gaaccagcaa ggcaattttc ctctccaagg   3660

aatgcaccca cgagccaaca tcatgagacc ccggacaaac acccccaagc aacttagaat   3720

gcagcttcag cagaggctgc agggccagca gtttttgaat cagagccgac aggcacttga   3780

attgaaaatg gaaaacccta ctgctggtgg tgctgcggtg atgaggccta tgatgcagcc   3840

ccagcagggt tttcttaatg ctcaaatggt cgcccaacgc agcagagagc tgctaagtca   3900

tcacttccga caacagaggg tggctatgat gatgcagcag cagcagcagc agcaacagca   3960

gcagcagcag cagcagcagc agcaacagca acagcaacag caacagcagc aacagcagca   4020

aacccaggcc ttcagcccac ctcctaatgt gactgcttcc cccagcatgg atgggctttt   4080

ggcaggaccc acaatgccac aagctcctcc gcaacagttt ccatatcaac caaattatgg   4140

aatgggacaa caaccagatc cagcctttgg tcgagtgtct agtcctccca atgcaatgat   4200

gtcgtcaaga atgggtccct cccagaatcc catgatgcaa cacccgcagg ctgcatccat   4260

ctatcagtcc tcagaaatga agggctggcc atcaggaaat ttggccagga acagctcctt   4320

ttcccagcag cagtttgccc accaggggaa tcctgcagtg tatagtatgg tgcacatgaa   4380

tggcagcagt ggtcacatgg gacagatgaa catgaacccc atgcccatgt ctggcatgcc   4440

tatgggtcct gatcagaaat actgctgaca tctctgcacc aggacctctt aaggaaacca   4500

ctgtacaaat gacactgcac taggattatt gggaaggaat cattgttcca ggcatccatc   4560

ttggaagaaa ggaccagctt tgagctccat caagggtatt ttaagtgatg tcatttgagc   4620

aggactggat tttaagccga agggcaatat ctacgtgttt ttcccccctc cttctgctgt   4680

gtatcatggt gttcaaaaca gaaatgtttt ttggcattcc acctcctagg gatataattc   4740

tggagacatg gagtgttact gatcataaaa cttttgtgtc acttttttct gccttgctag   4800

ccaaaatctc ttaaatacac gtaggtgggc cagagaacat tggaagaatc aagagagatt   4860

agaatatctg gtttctctag ttgcagtatt ggacaaagag catagtccca gccttcaggt   4920

gtagtagttc tgtgttgacc ctttgtccag tggaattggt gattctgaat tgtcctttac   4980

taatggtgtt gagttgctct gtccctatta tttgccctag gctttctcct aatgaaggtt   5040

ttcatttgcc attcatgtcc tgtaatactt cacctccagg aactgtcatg gatgtccaaa   5100

tggctttgca gaaaggaaat gagatgacag tatttaatcg cagcagtagc aaacttttca   5160

catgctaatg tgcagctgag tgcactttat ttaaaaagaa tggataaatg caatattctt   5220

gaggtcttga gggaatagtg aaacacattc ctggtttttg cctacactta cgtgttagac   5280

aagaactatg attttttttt ttaaagtact ggtgtcaccc tttgcctata tggtagagca   5340

ataatgcttt ttaaaaataa acttctgaaa acccaaggcc aggtactgca ttctgaatca   5400

gaatctcgca gtgtttctgt gaatagattt ttttgtaaat atgaccttta agatattgta   5460

ttatgtaaaa tatgtatata cctttttttg taggtcacaa caactcattt ttacagagtt   5520

tgtgaagcta aatatttaac attgttgatt tcagtaagct gtgtggtgag gctaccagtg   5580

gaagagacat cccttgactt ttgtggcctg ggggaggggt agtgctccac agcttttcct   5640

tccccacccc ccagccttag atgcctcgct cttttcaatc tcttaatcta aatgcttttt   5700

aaagagatta tttgtttaga tgtaggcatt ttaatttttt aaaaattcct ctaccagaac   5760

taagcacttt gttaatttgg ggggaaagaa tagatatggg gaaataaact taaaaaaaaa   5820

tcaggaattt aaaaaaacga gcaatttgaa gagaatcttt tggattttaa gcagtccgaa   5880

ataatagcaa ttcatgggct gtgtgtgtgt gtgtatgtgt gtgtgtgtgt gtgtatgttt   5940

aattatgtta ccttttcatc ccctttagga gcgttttcag attttggttg ctaagacctg   6000

aatcccatat tgagatctcg agtagaatcc ttggtgtggt ttctggtgtc tgctcagctg   6060

tcccctcatt ctactaatgt gatgctttca ttatgtccct gtggattaga atagtgtcag   6120

ttatttctta agtaactcag tacccagaac agccagtttt actgtgattc agagccacag   6180

tctaactgag caccttttaa acccctccct cttctgcccc ctaccacttt tctgctgttg   6240

cctctctttg acacctgttt tagtcagttg ggaggaaggg aaaaatcaag tttaattccc   6300

tttatctggg ttaattcatt tggttcaaat agttgacgga attgggtttc tgaatgtctg   6360

tgaatttcag aggtctctgc tagccttggt atcattttct agcaataact gagagccagt   6420

taattttaag aatttcacac atttagccaa tctttctaga tgtctctgaa ggtaagatca   6480

tttaatatct ttgatatgct tacgagtaag tgaatcctga ttatttccag acccaccacc   6540

agagtggatc ttattttcaa agcagtatag acaattatga gtttgccctc tttcccctac   6600

caagttcaaa atatatctaa gaaagattgt aaatccgaaa acttccattg tagtggcctg   6660

tgcttttcag atagtatact ctcctgtttg gagacagagg aagaaccagg tcagtctgtc   6720

tctttttcag ctcaattgta tctgaccctt ctttaagtta tgtgtgtggg gagaaataga   6780

atggtgctct tatctttctt gactttaaaa aaattattaa aaacaaaaaa aaaataaatt   6840

tttttgcaat cctttcctca gacctggctc caggctaact ggaaggcagc actccctttt   6900

ttatatagta gaaaaatgaa gtttattata agtttttata ttttctactt gttcatttgg   6960

tgcaaactca agatttcttt taataggtgc agtctttgag ataatttgtt tttacctgta   7020

ttgcccttta tcttttttag gtaattcttt gtactcctgc tgtctacctc tcctcacacc   7080

ccagcacccc ccattttttc aaaccttggt atctgttggg tgaacagtat aatcttttca   7140

tctgctttta gaatgtggga tatttccagt acctactttt tttttttttt tttgctgaat   7200

ccaaagatat ataaataaaa tatatatatt ttataaagat cagaatgata taaaggagat   7260

acatgtttct tcctttaaaa aataaacgga agttacattg ttaatgttca tattatgatg   7320

ccacttttct aaactgcatc tggattgaaa ggtgtaaata tcaataacag tgctacttag   7380

ttatcagtat ttaatatctg aggtgagttg ggggtatcta tattaggggt agggtattac   7440

agaagataat tggcttgatg tcctagaagt tctttgatcc agaggtgggt gcagctgaaa   7500

gtaaacagaa tggattgcca gttacatgta tgcctgccca gttccctttt tatttgcaga   7560

agctgtgagt tttgttcaca attaggttcc taggagcaaa acctcaagga ttgatttatt   7620

gttttcaact ccaaggcaca ctgttaataa acgagcaggg tgttttctct cttcctttct   7680

aatatatgga gtttcgaaga ataaaatatg agagcaatat ttaaattctc aggaattgac   7740

ttatactctt gagaatgaat tcagtttcaa tcaagtttac attatgttgc ttaaaaaaat   7800

agaaattatt ctttatcttg caaagaattg aaaccacatg aaatgactta tgggggatgg   7860

tgagctgtga ctgctttgct gaccattttg gatgtcattg taaataaagg tttctattta   7920

aaa                                                                 7923


<210>  1275
<211>  1420
<212>  PRT
<213>  Homo sapiens

<400>  1275

Met Ser Gly Leu Gly Glu Asn Leu Asp Pro Leu Ala Ser Asp Ser Arg 
1               5                   10                  15


Lys Arg Lys Leu Pro Cys Asp Thr Pro Gly Gln Gly Leu Thr Cys Ser 
            20                  25                  30


Gly Glu Lys Arg Arg Arg Glu Gln Glu Ser Lys Tyr Ile Glu Glu Leu 
        35                  40                  45


Ala Glu Leu Ile Ser Ala Asn Leu Ser Asp Ile Asp Asn Phe Asn Val 
    50                  55                  60


Lys Pro Asp Lys Cys Ala Ile Leu Lys Glu Thr Val Arg Gln Ile Arg 
65                  70                  75                  80


Gln Ile Lys Glu Gln Gly Lys Thr Ile Ser Asn Asp Asp Asp Val Gln 
                85                  90                  95


Lys Ala Asp Val Ser Ser Thr Gly Gln Gly Val Ile Asp Lys Asp Ser 
            100                 105                 110


Leu Gly Pro Leu Leu Leu Gln Ala Leu Asp Gly Phe Leu Phe Val Val 
        115                 120                 125


Asn Arg Asp Gly Asn Ile Val Phe Val Ser Glu Asn Val Thr Gln Tyr 
    130                 135                 140


Leu Gln Tyr Lys Gln Glu Asp Leu Val Asn Thr Ser Val Tyr Asn Ile 
145                 150                 155                 160


Leu His Glu Glu Asp Arg Lys Asp Phe Leu Lys Asn Leu Pro Lys Ser 
                165                 170                 175


Thr Val Asn Gly Val Ser Trp Thr Asn Glu Thr Gln Arg Gln Lys Ser 
            180                 185                 190


His Thr Phe Asn Cys Arg Met Leu Met Lys Thr Pro His Asp Ile Leu 
        195                 200                 205


Glu Asp Ile Asn Ala Ser Pro Glu Met Arg Gln Arg Tyr Glu Thr Met 
    210                 215                 220


Gln Cys Phe Ala Leu Ser Gln Pro Arg Ala Met Met Glu Glu Gly Glu 
225                 230                 235                 240


Asp Leu Gln Ser Cys Met Ile Cys Val Ala Arg Arg Ile Thr Thr Gly 
                245                 250                 255


Glu Arg Thr Phe Pro Ser Asn Pro Glu Ser Phe Ile Thr Arg His Asp 
            260                 265                 270


Leu Ser Gly Lys Val Val Asn Ile Asp Thr Asn Ser Leu Arg Ser Ser 
        275                 280                 285


Met Arg Pro Gly Phe Glu Asp Ile Ile Arg Arg Cys Ile Gln Arg Phe 
    290                 295                 300


Phe Ser Leu Asn Asp Gly Gln Ser Trp Ser Gln Lys Arg His Tyr Gln 
305                 310                 315                 320


Glu Ala Tyr Leu Asn Gly His Ala Glu Thr Pro Val Tyr Arg Phe Ser 
                325                 330                 335


Leu Ala Asp Gly Thr Ile Val Thr Ala Gln Thr Lys Ser Lys Leu Phe 
            340                 345                 350


Arg Asn Pro Val Thr Asn Asp Arg His Gly Phe Val Ser Thr His Phe 
        355                 360                 365


Leu Gln Arg Glu Gln Asn Gly Tyr Arg Pro Asn Pro Asn Pro Val Gly 
    370                 375                 380


Gln Gly Ile Arg Pro Pro Met Ala Gly Cys Asn Ser Ser Val Gly Gly 
385                 390                 395                 400


Met Ser Met Ser Pro Asn Gln Gly Leu Gln Met Pro Ser Ser Arg Ala 
                405                 410                 415


Tyr Gly Leu Ala Asp Pro Ser Thr Thr Gly Gln Met Ser Gly Ala Arg 
            420                 425                 430


Tyr Gly Gly Ser Ser Asn Ile Ala Ser Leu Thr Pro Gly Pro Gly Met 
        435                 440                 445


Gln Ser Pro Ser Ser Tyr Gln Asn Asn Asn Tyr Gly Leu Asn Met Ser 
    450                 455                 460


Ser Pro Pro His Gly Ser Pro Gly Leu Ala Pro Asn Gln Gln Asn Ile 
465                 470                 475                 480


Met Ile Ser Pro Arg Asn Arg Gly Ser Pro Lys Ile Ala Ser His Gln 
                485                 490                 495


Phe Ser Pro Val Ala Gly Val His Ser Pro Met Ala Ser Ser Gly Asn 
            500                 505                 510


Thr Gly Asn His Ser Phe Ser Ser Ser Ser Leu Ser Ala Leu Gln Ala 
        515                 520                 525


Ile Ser Glu Gly Val Gly Thr Ser Leu Leu Ser Thr Leu Ser Ser Pro 
    530                 535                 540


Gly Pro Lys Leu Asp Asn Ser Pro Asn Met Asn Ile Thr Gln Pro Ser 
545                 550                 555                 560


Lys Val Ser Asn Gln Asp Ser Lys Ser Pro Leu Gly Phe Tyr Cys Asp 
                565                 570                 575


Gln Asn Pro Val Glu Ser Ser Met Cys Gln Ser Asn Ser Arg Asp His 
            580                 585                 590


Leu Ser Asp Lys Glu Ser Lys Glu Ser Ser Val Glu Gly Ala Glu Asn 
        595                 600                 605


Gln Arg Gly Pro Leu Glu Ser Lys Gly His Lys Lys Leu Leu Gln Leu 
    610                 615                 620


Leu Thr Cys Ser Ser Asp Asp Arg Gly His Ser Ser Leu Thr Asn Ser 
625                 630                 635                 640


Pro Leu Asp Ser Ser Cys Lys Glu Ser Ser Val Ser Val Thr Ser Pro 
                645                 650                 655


Ser Gly Val Ser Ser Ser Thr Ser Gly Gly Val Ser Ser Thr Ser Asn 
            660                 665                 670


Met His Gly Ser Leu Leu Gln Glu Lys His Arg Ile Leu His Lys Leu 
        675                 680                 685


Leu Gln Asn Gly Asn Ser Pro Ala Glu Val Ala Lys Ile Thr Ala Glu 
    690                 695                 700


Ala Thr Gly Lys Asp Thr Ser Ser Ile Thr Ser Cys Gly Asp Gly Asn 
705                 710                 715                 720


Val Val Lys Gln Glu Gln Leu Ser Pro Lys Lys Lys Glu Asn Asn Ala 
                725                 730                 735


Leu Leu Arg Tyr Leu Leu Asp Arg Asp Asp Pro Ser Asp Ala Leu Ser 
            740                 745                 750


Lys Glu Leu Gln Pro Gln Val Glu Gly Val Asp Asn Lys Met Ser Gln 
        755                 760                 765


Cys Thr Ser Ser Thr Ile Pro Ser Ser Ser Gln Glu Lys Asp Pro Lys 
    770                 775                 780


Ile Lys Thr Glu Thr Ser Glu Glu Gly Ser Gly Asp Leu Asp Asn Leu 
785                 790                 795                 800


Asp Ala Ile Leu Gly Asp Leu Thr Ser Ser Asp Phe Tyr Asn Asn Ser 
                805                 810                 815


Ile Ser Ser Asn Gly Ser His Leu Gly Thr Lys Gln Gln Val Phe Gln 
            820                 825                 830


Gly Thr Asn Ser Leu Gly Leu Lys Ser Ser Gln Ser Val Gln Ser Ile 
        835                 840                 845


Arg Pro Pro Tyr Asn Arg Ala Val Ser Leu Asp Ser Pro Val Ser Val 
    850                 855                 860


Gly Ser Ser Pro Pro Val Lys Asn Ile Ser Ala Phe Pro Met Leu Pro 
865                 870                 875                 880


Lys Gln Pro Met Leu Gly Gly Asn Pro Arg Met Met Asp Ser Gln Glu 
                885                 890                 895


Asn Tyr Gly Ser Ser Met Gly Gly Pro Asn Arg Asn Val Thr Val Thr 
            900                 905                 910


Gln Thr Pro Ser Ser Gly Asp Trp Gly Leu Pro Asn Ser Lys Ala Gly 
        915                 920                 925


Arg Met Glu Pro Met Asn Ser Asn Ser Met Gly Arg Pro Gly Gly Asp 
    930                 935                 940


Tyr Asn Thr Ser Leu Pro Arg Pro Ala Leu Gly Gly Ser Ile Pro Thr 
945                 950                 955                 960


Leu Pro Leu Arg Ser Asn Ser Ile Pro Gly Ala Arg Pro Val Leu Gln 
                965                 970                 975


Gln Gln Gln Gln Met Leu Gln Met Arg Pro Gly Glu Ile Pro Met Gly 
            980                 985                 990


Met Gly Ala Asn Pro Tyr Gly Gln Ala Ala Ala Ser Asn Gln Leu Gly 
        995                 1000                1005


Ser Trp Pro Asp Gly Met Leu Ser Met Glu Gln Val Ser His Gly Thr 
    1010                1015                1020


Gln Asn Arg Pro Leu Leu Arg Asn Ser Leu Asp Asp Leu Val Gly Pro 
1025                1030                1035                1040


Pro Ser Asn Leu Glu Gly Gln Ser Asp Glu Arg Ala Leu Leu Asp Gln 
                1045                1050                1055


Leu His Thr Leu Leu Ser Asn Thr Asp Ala Thr Gly Leu Glu Glu Ile 
            1060                1065                1070


Asp Arg Ala Leu Gly Ile Pro Glu Leu Val Asn Gln Gly Gln Ala Leu 
        1075                1080                1085


Glu Pro Lys Gln Asp Ala Phe Gln Gly Gln Glu Ala Ala Val Met Met 
    1090                1095                1100


Asp Gln Lys Ala Gly Leu Tyr Gly Gln Thr Tyr Pro Ala Gln Gly Pro 
1105                1110                1115                1120


Pro Met Gln Gly Gly Phe His Leu Gln Gly Gln Ser Pro Ser Phe Asn 
                1125                1130                1135


Ser Met Met Asn Gln Met Asn Gln Gln Gly Asn Phe Pro Leu Gln Gly 
            1140                1145                1150


Met His Pro Arg Ala Asn Ile Met Arg Pro Arg Thr Asn Thr Pro Lys 
        1155                1160                1165


Gln Leu Arg Met Gln Leu Gln Gln Arg Leu Gln Gly Gln Gln Phe Leu 
    1170                1175                1180


Asn Gln Ser Arg Gln Ala Leu Glu Leu Lys Met Glu Asn Pro Thr Ala 
1185                1190                1195                1200


Gly Gly Ala Ala Val Met Arg Pro Met Met Gln Pro Gln Gln Gly Phe 
                1205                1210                1215


Leu Asn Ala Gln Met Val Ala Gln Arg Ser Arg Glu Leu Leu Ser His 
            1220                1225                1230


His Phe Arg Gln Gln Arg Val Ala Met Met Met Gln Gln Gln Gln Gln 
        1235                1240                1245


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    1250                1255                1260


Gln Gln Gln Gln Gln Gln Gln Gln Thr Gln Ala Phe Ser Pro Pro Pro 
1265                1270                1275                1280


Asn Val Thr Ala Ser Pro Ser Met Asp Gly Leu Leu Ala Gly Pro Thr 
                1285                1290                1295


Met Pro Gln Ala Pro Pro Gln Gln Phe Pro Tyr Gln Pro Asn Tyr Gly 
            1300                1305                1310


Met Gly Gln Gln Pro Asp Pro Ala Phe Gly Arg Val Ser Ser Pro Pro 
        1315                1320                1325


Asn Ala Met Met Ser Ser Arg Met Gly Pro Ser Gln Asn Pro Met Met 
    1330                1335                1340


Gln His Pro Gln Ala Ala Ser Ile Tyr Gln Ser Ser Glu Met Lys Gly 
1345                1350                1355                1360


Trp Pro Ser Gly Asn Leu Ala Arg Asn Ser Ser Phe Ser Gln Gln Gln 
                1365                1370                1375


Phe Ala His Gln Gly Asn Pro Ala Val Tyr Ser Met Val His Met Asn 
            1380                1385                1390


Gly Ser Ser Gly His Met Gly Gln Met Asn Met Asn Pro Met Pro Met 
        1395                1400                1405


Ser Gly Met Pro Met Gly Pro Asp Gln Lys Tyr Cys 
    1410                1415                1420


<210>  1276
<211>  7935
<212>  DNA
<213>  Homo sapiens

<400>  1276
agcgacggcg gcggctgcgg cttagtcggt ggcggccggc ggcggctgcg ggctgagcgg     60

cgagtttccg atttaaagct gagctgcgag gaaaatggcg gcgggaggat caaaatactt    120

gctggatggt ggactcagag accaataaaa ataaactgct tgaacatcct ttgactggtt    180

agccagttgc tgatgtatat tcaagatgag tggattagga gaaaacttgg atccactggc    240

cagtgattca cgaaaacgca aattgccatg tgatactcca ggacaaggtc ttacctgcag    300

tggtgaaaaa cggagacggg agcaggaaag taaatatatt gaagaattgg ctgagctgat    360

atctgccaat cttagtgata ttgacaattt caatgtcaaa ccagataaat gtgcgatttt    420

aaaggaaaca gtaagacaga tacgtcaaat aaaagagcaa ggaaaaacta tttccaatga    480

tgatgatgtt caaaaagccg atgtatcttc tacagggcag ggagttattg ataaagactc    540

cttaggaccg cttttacttc aggcattgga tggtttccta tttgtggtga atcgagacgg    600

aaacattgta tttgtatcag aaaatgtcac acaatacctg caatataagc aagaggacct    660

ggttaacaca agtgtttaca atatcttaca tgaagaagac agaaaggatt ttcttaagaa    720

tttaccaaaa tctacagtta atggagtttc ctggacaaat gagacccaaa gacaaaaaag    780

ccatacattt aattgccgta tgttgatgaa aacaccacat gatattctgg aagacataaa    840

cgccagtcct gaaatgcgcc agagatatga aacaatgcag tgctttgccc tgtctcagcc    900

acgagctatg atggaggaag gggaagattt gcaatcttgt atgatctgtg tggcacgccg    960

cattactaca ggagaaagaa catttccatc aaaccctgag agctttatta ccagacatga   1020

tctttcagga aaggttgtca atatagatac aaattcactg agatcctcca tgaggcctgg   1080

ctttgaagat ataatccgaa ggtgtattca gagatttttt agtctaaatg atgggcagtc   1140

atggtcccag aaacgtcact atcaagaagc ttatcttaat ggccatgcag aaaccccagt   1200

atatcgattc tcgttggctg atggaactat agtgactgca cagacaaaaa gcaaactctt   1260

ccgaaatcct gtaacaaatg atcgacatgg ctttgtctca acccacttcc ttcagagaga   1320

acagaatgga tatagaccaa acccaaatcc tgttggacaa gggattagac cacctatggc   1380

tggatgcaac agttcggtag gcggcatgag tatgtcgcca aaccaaggct tacagatgcc   1440

gagcagcagg gcctatggct tggcagaccc tagcaccaca gggcagatga gtggagctag   1500

gtatgggggt tccagtaaca tagcttcatt gacccctggg ccaggcatgc aatcaccatc   1560

ttcctaccag aacaacaact atgggctcaa catgagtagc cccccacatg ggagtcctgg   1620

tcttgcccca aaccagcaga atatcatgat ttctcctcgt aatcgtggga gtccaaagat   1680

agcctcacat cagttttctc ctgttgcagg tgtgcactct cccatggcat cttctggcaa   1740

tactgggaac cacagctttt ccagcagctc tctcagtgcc ctgcaagcca tcagtgaagg   1800

tgtggggact tcccttttat ctactctgtc atcaccaggc cccaaattgg ataactctcc   1860

caatatgaat attacccaac caagtaaagt aagcaatcag gattccaaga gtcctctggg   1920

cttttattgc gaccaaaatc cagtggagag ttcaatgtgt cagtcaaata gcagagatca   1980

cctcagtgac aaagaaagta aggagagcag tgttgagggg gcagagaatc aaaggggtcc   2040

tttggaaagc aaaggtcata aaaaattact gcagttactt acctgttctt ctgatgaccg   2100

gggtcattcc tccttgacca actcccccct agattcaagt tgtaaagaat cttctgttag   2160

tgtcaccagc ccctctggag tctcctcctc tacatctgga ggagtatcct ctacatccaa   2220

tatgcatggg tcactgttac aagagaagca ccggattttg cacaagttgc tgcagaatgg   2280

gaattcacca gctgaggtag ccaagattac tgcagaagcc actgggaaag acaccagcag   2340

tataacttct tgtggggacg gaaatgttgt caagcaggag cagctaagtc ctaagaagaa   2400

ggagaataat gcacttctta gatacctgct ggacagggat gatcctagtg atgcactctc   2460

taaagaacta cagccccaag tggaaggagt ggataataaa atgagtcagt gcaccagctc   2520

caccattcct agctcaagtc aagagaaaga ccctaaaatt aagacagaga caagtgaaga   2580

gggatctgga gacttggata atctagatgc tattcttggt gatctgacta gttctgactt   2640

ttacaataat tccatatcct caaatggtag tcatctgggg actaagcaac aggtgtttca   2700

aggaactaat tctctgggtt tgaaaagttc acagtctgtg cagtctattc gtcctccata   2760

taaccgagca gtgtctctgg atagccctgt ttctgttggc tcaagtcctc cagtaaaaaa   2820

tatcagtgct ttccccatgt taccaaagca acccatgttg ggtgggaatc caagaatgat   2880

ggatagtcag gaaaattatg gctcaagtat gggtgggcca aaccgaaatg tgactgtgac   2940

tcagactcct tcctcaggag actggggctt accaaactca aaggccggca gaatggaacc   3000

tatgaattca aactccatgg gaagaccagg aggagattat aatacttctt tacccagacc   3060

tgcactgggt ggctctattc ccacattgcc tcttcggtct aatagcatac caggtgcgag   3120

accagtattg caacagcagc agcagatgct tcaaatgagg cctggtgaaa tccccatggg   3180

aatgggggct aatccctatg gccaagcagc agcatctaac caactgggtt cctggcccga   3240

tggcatgttg tccatggaac aagtttctca tggcactcaa aataggcctc ttcttaggaa   3300

ttccctggat gatcttgttg ggccaccttc caacctggaa ggccagagtg acgaaagagc   3360

attattggac cagctgcaca ctcttctcag caacacagat gccacaggcc tggaagaaat   3420

tgacagagct ttgggcattc ctgaacttgt caatcaggga caggcattag agcccaaaca   3480

ggatgctttc caaggccaag aagcagcagt aatgatggat cagaaggcag gattatatgg   3540

acagacatac ccagcacagg ggcctccaat gcaaggaggc tttcatcttc agggacaatc   3600

accatctttt aactctatga tgaatcagat gaaccagcaa ggcaattttc ctctccaagg   3660

aatgcaccca cgagccaaca tcatgagacc ccggacaaac acccccaagc aacttagaat   3720

gcagcttcag cagaggctgc agggccagca gtttttgaat cagagccgac aggcacttga   3780

attgaaaatg gaaaacccta ctgctggtgg tgctgcggtg atgaggccta tgatgcagcc   3840

ccaggtgagc tcccagcagg gttttcttaa tgctcaaatg gtcgcccaac gcagcagaga   3900

gctgctaagt catcacttcc gacaacagag ggtggctatg atgatgcagc agcagcagca   3960

gcagcaacag cagcagcagc agcagcagca gcagcaacag caacagcaac agcaacagca   4020

gcaacagcag caaacccagg ccttcagccc acctcctaat gtgactgctt cccccagcat   4080

ggatgggctt ttggcaggac ccacaatgcc acaagctcct ccgcaacagt ttccatatca   4140

accaaattat ggaatgggac aacaaccaga tccagccttt ggtcgagtgt ctagtcctcc   4200

caatgcaatg atgtcgtcaa gaatgggtcc ctcccagaat cccatgatgc aacacccgca   4260

ggctgcatcc atctatcagt cctcagaaat gaagggctgg ccatcaggaa atttggccag   4320

gaacagctcc ttttcccagc agcagtttgc ccaccagggg aatcctgcag tgtatagtat   4380

ggtgcacatg aatggcagca gtggtcacat gggacagatg aacatgaacc ccatgcccat   4440

gtctggcatg cctatgggtc ctgatcagaa atactgctga catctctgca ccaggacctc   4500

ttaaggaaac cactgtacaa atgacactgc actaggatta ttgggaagga atcattgttc   4560

caggcatcca tcttggaaga aaggaccagc tttgagctcc atcaagggta ttttaagtga   4620

tgtcatttga gcaggactgg attttaagcc gaagggcaat atctacgtgt ttttcccccc   4680

tccttctgct gtgtatcatg gtgttcaaaa cagaaatgtt ttttggcatt ccacctccta   4740

gggatataat tctggagaca tggagtgtta ctgatcataa aacttttgtg tcactttttt   4800

ctgccttgct agccaaaatc tcttaaatac acgtaggtgg gccagagaac attggaagaa   4860

tcaagagaga ttagaatatc tggtttctct agttgcagta ttggacaaag agcatagtcc   4920

cagccttcag gtgtagtagt tctgtgttga ccctttgtcc agtggaattg gtgattctga   4980

attgtccttt actaatggtg ttgagttgct ctgtccctat tatttgccct aggctttctc   5040

ctaatgaagg ttttcatttg ccattcatgt cctgtaatac ttcacctcca ggaactgtca   5100

tggatgtcca aatggctttg cagaaaggaa atgagatgac agtatttaat cgcagcagta   5160

gcaaactttt cacatgctaa tgtgcagctg agtgcacttt atttaaaaag aatggataaa   5220

tgcaatattc ttgaggtctt gagggaatag tgaaacacat tcctggtttt tgcctacact   5280

tacgtgttag acaagaacta tgattttttt ttttaaagta ctggtgtcac cctttgccta   5340

tatggtagag caataatgct ttttaaaaat aaacttctga aaacccaagg ccaggtactg   5400

cattctgaat cagaatctcg cagtgtttct gtgaatagat ttttttgtaa atatgacctt   5460

taagatattg tattatgtaa aatatgtata tacctttttt tgtaggtcac aacaactcat   5520

ttttacagag tttgtgaagc taaatattta acattgttga tttcagtaag ctgtgtggtg   5580

aggctaccag tggaagagac atcccttgac ttttgtggcc tgggggaggg gtagtgctcc   5640

acagcttttc cttccccacc ccccagcctt agatgcctcg ctcttttcaa tctcttaatc   5700

taaatgcttt ttaaagagat tatttgttta gatgtaggca ttttaatttt ttaaaaattc   5760

ctctaccaga actaagcact ttgttaattt ggggggaaag aatagatatg gggaaataaa   5820

cttaaaaaaa aatcaggaat ttaaaaaaac gagcaatttg aagagaatct tttggatttt   5880

aagcagtccg aaataatagc aattcatggg ctgtgtgtgt gtgtgtatgt gtgtgtgtgt   5940

gtgtgtatgt ttaattatgt taccttttca tcccctttag gagcgttttc agattttggt   6000

tgctaagacc tgaatcccat attgagatct cgagtagaat ccttggtgtg gtttctggtg   6060

tctgctcagc tgtcccctca ttctactaat gtgatgcttt cattatgtcc ctgtggatta   6120

gaatagtgtc agttatttct taagtaactc agtacccaga acagccagtt ttactgtgat   6180

tcagagccac agtctaactg agcacctttt aaacccctcc ctcttctgcc ccctaccact   6240

tttctgctgt tgcctctctt tgacacctgt tttagtcagt tgggaggaag ggaaaaatca   6300

agtttaattc cctttatctg ggttaattca tttggttcaa atagttgacg gaattgggtt   6360

tctgaatgtc tgtgaatttc agaggtctct gctagccttg gtatcatttt ctagcaataa   6420

ctgagagcca gttaatttta agaatttcac acatttagcc aatctttcta gatgtctctg   6480

aaggtaagat catttaatat ctttgatatg cttacgagta agtgaatcct gattatttcc   6540

agacccacca ccagagtgga tcttattttc aaagcagtat agacaattat gagtttgccc   6600

tctttcccct accaagttca aaatatatct aagaaagatt gtaaatccga aaacttccat   6660

tgtagtggcc tgtgcttttc agatagtata ctctcctgtt tggagacaga ggaagaacca   6720

ggtcagtctg tctctttttc agctcaattg tatctgaccc ttctttaagt tatgtgtgtg   6780

gggagaaata gaatggtgct cttatctttc ttgactttaa aaaaattatt aaaaacaaaa   6840

aaaaaataaa tttttttgca atcctttcct cagacctggc tccaggctaa ctggaaggca   6900

gcactccctt ttttatatag tagaaaaatg aagtttatta taagttttta tattttctac   6960

ttgttcattt ggtgcaaact caagatttct tttaataggt gcagtctttg agataatttg   7020

tttttacctg tattgccctt tatctttttt aggtaattct ttgtactcct gctgtctacc   7080

tctcctcaca ccccagcacc ccccattttt tcaaaccttg gtatctgttg ggtgaacagt   7140

ataatctttt catctgcttt tagaatgtgg gatatttcca gtacctactt tttttttttt   7200

tttttgctga atccaaagat atataaataa aatatatata ttttataaag atcagaatga   7260

tataaaggag atacatgttt cttcctttaa aaaataaacg gaagttacat tgttaatgtt   7320

catattatga tgccactttt ctaaactgca tctggattga aaggtgtaaa tatcaataac   7380

agtgctactt agttatcagt atttaatatc tgaggtgagt tgggggtatc tatattaggg   7440

gtagggtatt acagaagata attggcttga tgtcctagaa gttctttgat ccagaggtgg   7500

gtgcagctga aagtaaacag aatggattgc cagttacatg tatgcctgcc cagttccctt   7560

tttatttgca gaagctgtga gttttgttca caattaggtt cctaggagca aaacctcaag   7620

gattgattta ttgttttcaa ctccaaggca cactgttaat aaacgagcag ggtgttttct   7680

ctcttccttt ctaatatatg gagtttcgaa gaataaaata tgagagcaat atttaaattc   7740

tcaggaattg acttatactc ttgagaatga attcagtttc aatcaagttt acattatgtt   7800

gcttaaaaaa atagaaatta ttctttatct tgcaaagaat tgaaaccaca tgaaatgact   7860

tatgggggat ggtgagctgt gactgctttg ctgaccattt tggatgtcat tgtaaataaa   7920

ggtttctatt taaaa                                                    7935


<210>  1277
<211>  1424
<212>  PRT
<213>  Homo sapiens

<400>  1277

Met Ser Gly Leu Gly Glu Asn Leu Asp Pro Leu Ala Ser Asp Ser Arg 
1               5                   10                  15


Lys Arg Lys Leu Pro Cys Asp Thr Pro Gly Gln Gly Leu Thr Cys Ser 
            20                  25                  30


Gly Glu Lys Arg Arg Arg Glu Gln Glu Ser Lys Tyr Ile Glu Glu Leu 
        35                  40                  45


Ala Glu Leu Ile Ser Ala Asn Leu Ser Asp Ile Asp Asn Phe Asn Val 
    50                  55                  60


Lys Pro Asp Lys Cys Ala Ile Leu Lys Glu Thr Val Arg Gln Ile Arg 
65                  70                  75                  80


Gln Ile Lys Glu Gln Gly Lys Thr Ile Ser Asn Asp Asp Asp Val Gln 
                85                  90                  95


Lys Ala Asp Val Ser Ser Thr Gly Gln Gly Val Ile Asp Lys Asp Ser 
            100                 105                 110


Leu Gly Pro Leu Leu Leu Gln Ala Leu Asp Gly Phe Leu Phe Val Val 
        115                 120                 125


Asn Arg Asp Gly Asn Ile Val Phe Val Ser Glu Asn Val Thr Gln Tyr 
    130                 135                 140


Leu Gln Tyr Lys Gln Glu Asp Leu Val Asn Thr Ser Val Tyr Asn Ile 
145                 150                 155                 160


Leu His Glu Glu Asp Arg Lys Asp Phe Leu Lys Asn Leu Pro Lys Ser 
                165                 170                 175


Thr Val Asn Gly Val Ser Trp Thr Asn Glu Thr Gln Arg Gln Lys Ser 
            180                 185                 190


His Thr Phe Asn Cys Arg Met Leu Met Lys Thr Pro His Asp Ile Leu 
        195                 200                 205


Glu Asp Ile Asn Ala Ser Pro Glu Met Arg Gln Arg Tyr Glu Thr Met 
    210                 215                 220


Gln Cys Phe Ala Leu Ser Gln Pro Arg Ala Met Met Glu Glu Gly Glu 
225                 230                 235                 240


Asp Leu Gln Ser Cys Met Ile Cys Val Ala Arg Arg Ile Thr Thr Gly 
                245                 250                 255


Glu Arg Thr Phe Pro Ser Asn Pro Glu Ser Phe Ile Thr Arg His Asp 
            260                 265                 270


Leu Ser Gly Lys Val Val Asn Ile Asp Thr Asn Ser Leu Arg Ser Ser 
        275                 280                 285


Met Arg Pro Gly Phe Glu Asp Ile Ile Arg Arg Cys Ile Gln Arg Phe 
    290                 295                 300


Phe Ser Leu Asn Asp Gly Gln Ser Trp Ser Gln Lys Arg His Tyr Gln 
305                 310                 315                 320


Glu Ala Tyr Leu Asn Gly His Ala Glu Thr Pro Val Tyr Arg Phe Ser 
                325                 330                 335


Leu Ala Asp Gly Thr Ile Val Thr Ala Gln Thr Lys Ser Lys Leu Phe 
            340                 345                 350


Arg Asn Pro Val Thr Asn Asp Arg His Gly Phe Val Ser Thr His Phe 
        355                 360                 365


Leu Gln Arg Glu Gln Asn Gly Tyr Arg Pro Asn Pro Asn Pro Val Gly 
    370                 375                 380


Gln Gly Ile Arg Pro Pro Met Ala Gly Cys Asn Ser Ser Val Gly Gly 
385                 390                 395                 400


Met Ser Met Ser Pro Asn Gln Gly Leu Gln Met Pro Ser Ser Arg Ala 
                405                 410                 415


Tyr Gly Leu Ala Asp Pro Ser Thr Thr Gly Gln Met Ser Gly Ala Arg 
            420                 425                 430


Tyr Gly Gly Ser Ser Asn Ile Ala Ser Leu Thr Pro Gly Pro Gly Met 
        435                 440                 445


Gln Ser Pro Ser Ser Tyr Gln Asn Asn Asn Tyr Gly Leu Asn Met Ser 
    450                 455                 460


Ser Pro Pro His Gly Ser Pro Gly Leu Ala Pro Asn Gln Gln Asn Ile 
465                 470                 475                 480


Met Ile Ser Pro Arg Asn Arg Gly Ser Pro Lys Ile Ala Ser His Gln 
                485                 490                 495


Phe Ser Pro Val Ala Gly Val His Ser Pro Met Ala Ser Ser Gly Asn 
            500                 505                 510


Thr Gly Asn His Ser Phe Ser Ser Ser Ser Leu Ser Ala Leu Gln Ala 
        515                 520                 525


Ile Ser Glu Gly Val Gly Thr Ser Leu Leu Ser Thr Leu Ser Ser Pro 
    530                 535                 540


Gly Pro Lys Leu Asp Asn Ser Pro Asn Met Asn Ile Thr Gln Pro Ser 
545                 550                 555                 560


Lys Val Ser Asn Gln Asp Ser Lys Ser Pro Leu Gly Phe Tyr Cys Asp 
                565                 570                 575


Gln Asn Pro Val Glu Ser Ser Met Cys Gln Ser Asn Ser Arg Asp His 
            580                 585                 590


Leu Ser Asp Lys Glu Ser Lys Glu Ser Ser Val Glu Gly Ala Glu Asn 
        595                 600                 605


Gln Arg Gly Pro Leu Glu Ser Lys Gly His Lys Lys Leu Leu Gln Leu 
    610                 615                 620


Leu Thr Cys Ser Ser Asp Asp Arg Gly His Ser Ser Leu Thr Asn Ser 
625                 630                 635                 640


Pro Leu Asp Ser Ser Cys Lys Glu Ser Ser Val Ser Val Thr Ser Pro 
                645                 650                 655


Ser Gly Val Ser Ser Ser Thr Ser Gly Gly Val Ser Ser Thr Ser Asn 
            660                 665                 670


Met His Gly Ser Leu Leu Gln Glu Lys His Arg Ile Leu His Lys Leu 
        675                 680                 685


Leu Gln Asn Gly Asn Ser Pro Ala Glu Val Ala Lys Ile Thr Ala Glu 
    690                 695                 700


Ala Thr Gly Lys Asp Thr Ser Ser Ile Thr Ser Cys Gly Asp Gly Asn 
705                 710                 715                 720


Val Val Lys Gln Glu Gln Leu Ser Pro Lys Lys Lys Glu Asn Asn Ala 
                725                 730                 735


Leu Leu Arg Tyr Leu Leu Asp Arg Asp Asp Pro Ser Asp Ala Leu Ser 
            740                 745                 750


Lys Glu Leu Gln Pro Gln Val Glu Gly Val Asp Asn Lys Met Ser Gln 
        755                 760                 765


Cys Thr Ser Ser Thr Ile Pro Ser Ser Ser Gln Glu Lys Asp Pro Lys 
    770                 775                 780


Ile Lys Thr Glu Thr Ser Glu Glu Gly Ser Gly Asp Leu Asp Asn Leu 
785                 790                 795                 800


Asp Ala Ile Leu Gly Asp Leu Thr Ser Ser Asp Phe Tyr Asn Asn Ser 
                805                 810                 815


Ile Ser Ser Asn Gly Ser His Leu Gly Thr Lys Gln Gln Val Phe Gln 
            820                 825                 830


Gly Thr Asn Ser Leu Gly Leu Lys Ser Ser Gln Ser Val Gln Ser Ile 
        835                 840                 845


Arg Pro Pro Tyr Asn Arg Ala Val Ser Leu Asp Ser Pro Val Ser Val 
    850                 855                 860


Gly Ser Ser Pro Pro Val Lys Asn Ile Ser Ala Phe Pro Met Leu Pro 
865                 870                 875                 880


Lys Gln Pro Met Leu Gly Gly Asn Pro Arg Met Met Asp Ser Gln Glu 
                885                 890                 895


Asn Tyr Gly Ser Ser Met Gly Gly Pro Asn Arg Asn Val Thr Val Thr 
            900                 905                 910


Gln Thr Pro Ser Ser Gly Asp Trp Gly Leu Pro Asn Ser Lys Ala Gly 
        915                 920                 925


Arg Met Glu Pro Met Asn Ser Asn Ser Met Gly Arg Pro Gly Gly Asp 
    930                 935                 940


Tyr Asn Thr Ser Leu Pro Arg Pro Ala Leu Gly Gly Ser Ile Pro Thr 
945                 950                 955                 960


Leu Pro Leu Arg Ser Asn Ser Ile Pro Gly Ala Arg Pro Val Leu Gln 
                965                 970                 975


Gln Gln Gln Gln Met Leu Gln Met Arg Pro Gly Glu Ile Pro Met Gly 
            980                 985                 990


Met Gly Ala Asn Pro Tyr Gly Gln Ala Ala Ala Ser Asn Gln Leu Gly 
        995                 1000                1005


Ser Trp Pro Asp Gly Met Leu Ser Met Glu Gln Val Ser His Gly Thr 
    1010                1015                1020


Gln Asn Arg Pro Leu Leu Arg Asn Ser Leu Asp Asp Leu Val Gly Pro 
1025                1030                1035                1040


Pro Ser Asn Leu Glu Gly Gln Ser Asp Glu Arg Ala Leu Leu Asp Gln 
                1045                1050                1055


Leu His Thr Leu Leu Ser Asn Thr Asp Ala Thr Gly Leu Glu Glu Ile 
            1060                1065                1070


Asp Arg Ala Leu Gly Ile Pro Glu Leu Val Asn Gln Gly Gln Ala Leu 
        1075                1080                1085


Glu Pro Lys Gln Asp Ala Phe Gln Gly Gln Glu Ala Ala Val Met Met 
    1090                1095                1100


Asp Gln Lys Ala Gly Leu Tyr Gly Gln Thr Tyr Pro Ala Gln Gly Pro 
1105                1110                1115                1120


Pro Met Gln Gly Gly Phe His Leu Gln Gly Gln Ser Pro Ser Phe Asn 
                1125                1130                1135


Ser Met Met Asn Gln Met Asn Gln Gln Gly Asn Phe Pro Leu Gln Gly 
            1140                1145                1150


Met His Pro Arg Ala Asn Ile Met Arg Pro Arg Thr Asn Thr Pro Lys 
        1155                1160                1165


Gln Leu Arg Met Gln Leu Gln Gln Arg Leu Gln Gly Gln Gln Phe Leu 
    1170                1175                1180


Asn Gln Ser Arg Gln Ala Leu Glu Leu Lys Met Glu Asn Pro Thr Ala 
1185                1190                1195                1200


Gly Gly Ala Ala Val Met Arg Pro Met Met Gln Pro Gln Val Ser Ser 
                1205                1210                1215


Gln Gln Gly Phe Leu Asn Ala Gln Met Val Ala Gln Arg Ser Arg Glu 
            1220                1225                1230


Leu Leu Ser His His Phe Arg Gln Gln Arg Val Ala Met Met Met Gln 
        1235                1240                1245


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    1250                1255                1260


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Thr Gln Ala Phe 
1265                1270                1275                1280


Ser Pro Pro Pro Asn Val Thr Ala Ser Pro Ser Met Asp Gly Leu Leu 
                1285                1290                1295


Ala Gly Pro Thr Met Pro Gln Ala Pro Pro Gln Gln Phe Pro Tyr Gln 
            1300                1305                1310


Pro Asn Tyr Gly Met Gly Gln Gln Pro Asp Pro Ala Phe Gly Arg Val 
        1315                1320                1325


Ser Ser Pro Pro Asn Ala Met Met Ser Ser Arg Met Gly Pro Ser Gln 
    1330                1335                1340


Asn Pro Met Met Gln His Pro Gln Ala Ala Ser Ile Tyr Gln Ser Ser 
1345                1350                1355                1360


Glu Met Lys Gly Trp Pro Ser Gly Asn Leu Ala Arg Asn Ser Ser Phe 
                1365                1370                1375


Ser Gln Gln Gln Phe Ala His Gln Gly Asn Pro Ala Val Tyr Ser Met 
            1380                1385                1390


Val His Met Asn Gly Ser Ser Gly His Met Gly Gln Met Asn Met Asn 
        1395                1400                1405


Pro Met Pro Met Ser Gly Met Pro Met Gly Pro Asp Gln Lys Tyr Cys 
    1410                1415                1420


<210>  1278
<211>  3897
<212>  DNA
<213>  Homo sapiens

<400>  1278
gagcgagagt gtgtcgagtg agtgtgcgtc tgtgtgtccc ggcgagggtg cgcgctcggc     60

gccgggagcg cggccagccg agtccggagg catcgggagg tcgagagccg ccgggacccc    120

agctctgcgt tcactgcccc gtccggagct ggacttcggg gccggggccg gggccgtgcg    180

ccggggacag gcagggccgg gtcgcgggcc gcgcgtcccc caggccggag atctgcgagt    240

gaagagggac gagggaaaag aaacaaagcc acagacgcaa cttgagactc ccgcatccca    300

aaagaagcac cagatcagca aaaaaagaag atgggccccc cgagcctcgt gctgtgcttg    360

ctgtccgcaa ctgtgttctc cctgctgggt ggaagctcgg ccttcctgtc gcaccaccgc    420

ctgaaaggca ggtttcagag ggaccgcagg aacatccgcc ccaacatcat cctggtgctg    480

acggacgacc aggatgtgga gctgggttcc atgcaggtga tgaacaagac ccggcgcatc    540

atggagcagg gcggggcgca cttcatcaac gccttcgtga ccacacccat gtgctgcccc    600

tcacgctcct ccatcctcac tggcaagtac gtccacaacc acaacaccta caccaacaat    660

gagaactgct cctcgccctc ctggcaggca cagcacgaga gccgcacctt tgccgtgtac    720

ctcaatagca ctggctaccg gacagctttc ttcgggaagt atcttaatga atacaacggc    780

tcctacgtgc cacccggctg gaaggagtgg gtcggactcc ttaaaaactc ccgcttttat    840

aactacacgc tgtgtcggaa cggggtgaaa gagaagcacg gctccgacta ctccaaggat    900

tacctcacag acctcatcac caatgacagc gtgagcttct tccgcacgtc caagaagatg    960

tacccgcaca ggccagtcct catggtcatc agccatgcag ccccccacgg ccctgaggat   1020

tcagccccac aatattcacg cctcttccca aacgcatctc agcacatcac gccgagctac   1080

aactacgcgc ccaacccgga caaacactgg atcatgcgct acacggggcc catgaagccc   1140

atccacatgg aattcaccaa catgctccag cggaagcgct tgcagaccct catgtcggtg   1200

gacgactcca tggagacgat ttacaacatg ctggttgaga cgggcgagct ggacaacacg   1260

tacatcgtat acaccgccga ccacggttac cacatcggcc agtttggcct ggtgaaaggg   1320

aaatccatgc catatgagtt tgacatcagg gtcccgttct acgtgagggg ccccaacgtg   1380

gaagccggct gtctgaatcc ccacatcgtc ctcaacattg acctggcccc caccatcctg   1440

gacattgcag gcctggacat acctgcggat atggacggga aatccatcct caagctgctg   1500

gacacggagc ggccggtgaa tcggtttcac ttgaaaaaga agatgagggt ctggcgggac   1560

tccttcttgg tggagagagg caagctgcta cacaagagag acaatgacaa ggtggacgcc   1620

caggaggaga actttctgcc caagtaccag cgtgtgaagg acctgtgtca gcgtgctgag   1680

taccagacgg cgtgtgagca gctgggacag aagtggcagt gtgtggagga cgccacgggg   1740

aagctgaagc tgcataagtg caagggcccc atgcggctgg gcggcagcag agccctctcc   1800

aacctcgtgc ccaagtacta cgggcagggc agcgaggcct gcacctgtga cagcggggac   1860

tacaagctca gcctggccgg acgccggaaa aaactcttca agaagaagta caaggccagc   1920

tatgtccgca gtcgctccat ccgctcagtg gccatcgagg tggacggcag ggtgtaccac   1980

gtaggcctgg gtgatgccgc ccagccccga aacctcacca agcggcactg gccaggggcc   2040

cctgaggacc aagatgacaa ggatggtggg gacttcagtg gcactggagg ccttcccgac   2100

tactcagccg ccaaccccat taaagtgaca catcggtgct acatcctaga gaacgacaca   2160

gtccagtgtg acctggacct gtacaagtcc ctgcaggcct ggaaagacca caagctgcac   2220

atcgaccacg agattgaaac cctgcagaac aaaattaaga acctgaggga agtccgaggt   2280

cacctgaaga aaaagcggcc agaagaatgt gactgtcaca aaatcagcta ccacacccag   2340

cacaaaggcc gcctcaagca cagaggctcc agtctgcatc ctttcaggaa gggcctgcaa   2400

gagaaggaca aggtgtggct gttgcgggag cagaagcgca agaagaaact ccgcaagctg   2460

ctcaagcgcc tgcagaacaa cgacacgtgc agcatgccag gcctcacgtg cttcacccac   2520

gacaaccagc actggcagac ggcgcctttc tggacactgg ggcctttctg tgcctgcacc   2580

agcgccaaca ataacacgta ctggtgcatg aggaccatca atgagactca caatttcctc   2640

ttctgtgaat ttgcaactgg cttcctagag tactttgatc tcaacacaga cccctaccag   2700

ctgatgaatg cagtgaacac actggacagg gatgtcctca accagctaca cgtacagctc   2760

atggagctga ggagctgcaa gggttacaag cagtgtaacc cccggactcg aaacatggac   2820

ctgggactta aagatggagg aagctatgag caatacaggc agtttcagcg tcgaaagtgg   2880

ccagaaatga agagaccttc ttccaaatca ctgggacaac tgtgggaagg ctgggaaggt   2940

taagaaacaa cagaggtgga cctccaaaaa catagaggca tcacctgact gcacaggcaa   3000

tgaaaaacca tgtgggtgat ttccagcaga cctgtggtat tggccaggag gcctgagaaa   3060

gcaagcacgc actctcagtc aacatgacag attctggagg ataaccagca ggagcagaga   3120

taacttcagg aagtccattt ttgcccctgc ttttgctttg gattatacct caccagctgc   3180

acaaaatgca ttttttcgta tcaaaaagtc accactaacc ctcccccaga agctcacaaa   3240

ggaaaacgga gagagcgagc gagagagatt tccttggaaa tttctcccaa gggcgaaagt   3300

cattggaatt tttaaatcat aggggaaaag cagtcctgtt ctaaatcctc ttattctttt   3360

ggtttgtcac aaagaaggaa ctaagaagca ggacagaggc aacgtggaga ggctgaaaac   3420

agtgcagaga cgtttgacaa tgagtcagta gcacaaaaga gatgacattt acctagcact   3480

ataaaccctg gttgcctctg aagaaactgc cttcattgta tatatgtgac tatttacatg   3540

taatcaacat gggaactttt aggggaacct aataagaaat cccaattttc aggagtggtg   3600

gtgtcaataa acgctctgtg gccagtgtaa aagaaaatcc ctcgcagttg tggacatttc   3660

tgttcctgtc cagataccat ttctcctagt atttctttgt tatgtcccag aactgatgtt   3720

ttttttttaa ggtactgaaa agaaatgaag ttgatgtatg tcccaagttt tgatgaaact   3780

gtatttgtaa aaaaaatttt gtagtttaag tattgtcata cagtgttcaa aaccccagcc   3840

aatgaccagc agttggtatg aagaaccttt gacattttgt aaaaggccat ttcttgg      3897


<210>  1279
<211>  870
<212>  PRT
<213>  Homo sapiens

<400>  1279

Met Gly Pro Pro Ser Leu Val Leu Cys Leu Leu Ser Ala Thr Val Phe 
1               5                   10                  15


Ser Leu Leu Gly Gly Ser Ser Ala Phe Leu Ser His His Arg Leu Lys 
            20                  25                  30


Gly Arg Phe Gln Arg Asp Arg Arg Asn Ile Arg Pro Asn Ile Ile Leu 
        35                  40                  45


Val Leu Thr Asp Asp Gln Asp Val Glu Leu Gly Ser Met Gln Val Met 
    50                  55                  60


Asn Lys Thr Arg Arg Ile Met Glu Gln Gly Gly Ala His Phe Ile Asn 
65                  70                  75                  80


Ala Phe Val Thr Thr Pro Met Cys Cys Pro Ser Arg Ser Ser Ile Leu 
                85                  90                  95


Thr Gly Lys Tyr Val His Asn His Asn Thr Tyr Thr Asn Asn Glu Asn 
            100                 105                 110


Cys Ser Ser Pro Ser Trp Gln Ala Gln His Glu Ser Arg Thr Phe Ala 
        115                 120                 125


Val Tyr Leu Asn Ser Thr Gly Tyr Arg Thr Ala Phe Phe Gly Lys Tyr 
    130                 135                 140


Leu Asn Glu Tyr Asn Gly Ser Tyr Val Pro Pro Gly Trp Lys Glu Trp 
145                 150                 155                 160


Val Gly Leu Leu Lys Asn Ser Arg Phe Tyr Asn Tyr Thr Leu Cys Arg 
                165                 170                 175


Asn Gly Val Lys Glu Lys His Gly Ser Asp Tyr Ser Lys Asp Tyr Leu 
            180                 185                 190


Thr Asp Leu Ile Thr Asn Asp Ser Val Ser Phe Phe Arg Thr Ser Lys 
        195                 200                 205


Lys Met Tyr Pro His Arg Pro Val Leu Met Val Ile Ser His Ala Ala 
    210                 215                 220


Pro His Gly Pro Glu Asp Ser Ala Pro Gln Tyr Ser Arg Leu Phe Pro 
225                 230                 235                 240


Asn Ala Ser Gln His Ile Thr Pro Ser Tyr Asn Tyr Ala Pro Asn Pro 
                245                 250                 255


Asp Lys His Trp Ile Met Arg Tyr Thr Gly Pro Met Lys Pro Ile His 
            260                 265                 270


Met Glu Phe Thr Asn Met Leu Gln Arg Lys Arg Leu Gln Thr Leu Met 
        275                 280                 285


Ser Val Asp Asp Ser Met Glu Thr Ile Tyr Asn Met Leu Val Glu Thr 
    290                 295                 300


Gly Glu Leu Asp Asn Thr Tyr Ile Val Tyr Thr Ala Asp His Gly Tyr 
305                 310                 315                 320


His Ile Gly Gln Phe Gly Leu Val Lys Gly Lys Ser Met Pro Tyr Glu 
                325                 330                 335


Phe Asp Ile Arg Val Pro Phe Tyr Val Arg Gly Pro Asn Val Glu Ala 
            340                 345                 350


Gly Cys Leu Asn Pro His Ile Val Leu Asn Ile Asp Leu Ala Pro Thr 
        355                 360                 365


Ile Leu Asp Ile Ala Gly Leu Asp Ile Pro Ala Asp Met Asp Gly Lys 
    370                 375                 380


Ser Ile Leu Lys Leu Leu Asp Thr Glu Arg Pro Val Asn Arg Phe His 
385                 390                 395                 400


Leu Lys Lys Lys Met Arg Val Trp Arg Asp Ser Phe Leu Val Glu Arg 
                405                 410                 415


Gly Lys Leu Leu His Lys Arg Asp Asn Asp Lys Val Asp Ala Gln Glu 
            420                 425                 430


Glu Asn Phe Leu Pro Lys Tyr Gln Arg Val Lys Asp Leu Cys Gln Arg 
        435                 440                 445


Ala Glu Tyr Gln Thr Ala Cys Glu Gln Leu Gly Gln Lys Trp Gln Cys 
    450                 455                 460


Val Glu Asp Ala Thr Gly Lys Leu Lys Leu His Lys Cys Lys Gly Pro 
465                 470                 475                 480


Met Arg Leu Gly Gly Ser Arg Ala Leu Ser Asn Leu Val Pro Lys Tyr 
                485                 490                 495


Tyr Gly Gln Gly Ser Glu Ala Cys Thr Cys Asp Ser Gly Asp Tyr Lys 
            500                 505                 510


Leu Ser Leu Ala Gly Arg Arg Lys Lys Leu Phe Lys Lys Lys Tyr Lys 
        515                 520                 525


Ala Ser Tyr Val Arg Ser Arg Ser Ile Arg Ser Val Ala Ile Glu Val 
    530                 535                 540


Asp Gly Arg Val Tyr His Val Gly Leu Gly Asp Ala Ala Gln Pro Arg 
545                 550                 555                 560


Asn Leu Thr Lys Arg His Trp Pro Gly Ala Pro Glu Asp Gln Asp Asp 
                565                 570                 575


Lys Asp Gly Gly Asp Phe Ser Gly Thr Gly Gly Leu Pro Asp Tyr Ser 
            580                 585                 590


Ala Ala Asn Pro Ile Lys Val Thr His Arg Cys Tyr Ile Leu Glu Asn 
        595                 600                 605


Asp Thr Val Gln Cys Asp Leu Asp Leu Tyr Lys Ser Leu Gln Ala Trp 
    610                 615                 620


Lys Asp His Lys Leu His Ile Asp His Glu Ile Glu Thr Leu Gln Asn 
625                 630                 635                 640


Lys Ile Lys Asn Leu Arg Glu Val Arg Gly His Leu Lys Lys Lys Arg 
                645                 650                 655


Pro Glu Glu Cys Asp Cys His Lys Ile Ser Tyr His Thr Gln His Lys 
            660                 665                 670


Gly Arg Leu Lys His Arg Gly Ser Ser Leu His Pro Phe Arg Lys Gly 
        675                 680                 685


Leu Gln Glu Lys Asp Lys Val Trp Leu Leu Arg Glu Gln Lys Arg Lys 
    690                 695                 700


Lys Lys Leu Arg Lys Leu Leu Lys Arg Leu Gln Asn Asn Asp Thr Cys 
705                 710                 715                 720


Ser Met Pro Gly Leu Thr Cys Phe Thr His Asp Asn Gln His Trp Gln 
                725                 730                 735


Thr Ala Pro Phe Trp Thr Leu Gly Pro Phe Cys Ala Cys Thr Ser Ala 
            740                 745                 750


Asn Asn Asn Thr Tyr Trp Cys Met Arg Thr Ile Asn Glu Thr His Asn 
        755                 760                 765


Phe Leu Phe Cys Glu Phe Ala Thr Gly Phe Leu Glu Tyr Phe Asp Leu 
    770                 775                 780


Asn Thr Asp Pro Tyr Gln Leu Met Asn Ala Val Asn Thr Leu Asp Arg 
785                 790                 795                 800


Asp Val Leu Asn Gln Leu His Val Gln Leu Met Glu Leu Arg Ser Cys 
                805                 810                 815


Lys Gly Tyr Lys Gln Cys Asn Pro Arg Thr Arg Asn Met Asp Leu Gly 
            820                 825                 830


Leu Lys Asp Gly Gly Ser Tyr Glu Gln Tyr Arg Gln Phe Gln Arg Arg 
        835                 840                 845


Lys Trp Pro Glu Met Lys Arg Pro Ser Ser Lys Ser Leu Gly Gln Leu 
    850                 855                 860


Trp Glu Gly Trp Glu Gly 
865                 870


<210>  1280
<211>  3843
<212>  DNA
<213>  Homo sapiens

<400>  1280
gagcgagagt gtgtcgagtg agtgtgcgtc tgtgtgtccc ggcgagggtg cgcgctcggc     60

gccgggagcg cggccagccg agtccggagg catcgggagg tcgagagccg ccgggacccc    120

agctctgcgt tcactgcccc gtccggagct ggacttcggg gccggggccg gggccgtgcg    180

ccggggacag gcagggccgg gtcgcgggcc gcgcgtcccc caggccggag atctgcgagt    240

gaagagggac gagggaaaag aaacaaagcc acagacgcaa cttgagactc ccgcatccca    300

aaagaagcac cagatcagca aaaaaagaag atgggccccc cgagcctcgt gctgtgcttg    360

ctgtccgcaa ctgtgttctc cctgctgggt ggaagctcgg ccttcctgtc gcaccaccgc    420

ctgaaaggca ggtttcagag ggaccgcagg aacatccgcc ccaacatcat cctggtgctg    480

acggacgacc aggatgtgga gctgggttcc atgcaggtga tgaacaagac ccggcgcatc    540

atggagcagg gcggggcgca cttcatcaac gccttcgtga ccacacccat gtgctgcccc    600

tcacgctcct ccatcctcac tggcaagtac gtccacaacc acaacaccta caccaacaat    660

gagaactgct cctcgccctc ctggcaggca cagcacgaga gccgcacctt tgccgtgtac    720

ctcaatagca ctggctaccg gacagctttc ttcgggaagt atcttaatga atacaacggc    780

tcctacgtgc cacccggctg gaaggagtgg gtcggactcc ttaaaaactc ccgcttttat    840

aactacacgc tgtgtcggaa cggggtgaaa gagaagcacg gctccgacta ctccaaggat    900

tacctcacag acctcatcac caatgacagc gtgagcttct tccgcacgtc caagaagatg    960

tacccgcaca ggccagtcct catggtcatc agccatgcag ccccccacgg ccctgaggat   1020

tcagccccac aatattcacg cctcttccca aacgcatctc agcacatcac gccgagctac   1080

aactacgcgc ccaacccgga caaacactgg atcatgcgct acacggggcc catgaagccc   1140

atccacatgg aattcaccaa catgctccag cggaagcgct tgcagaccct catgtcggtg   1200

gacgactcca tggagacgat ttacaacatg ctggttgaga cgggcgagct ggacaacacg   1260

tacatcgtat acaccgccga ccacggttac cacatcggcc agtttggcct ggtgaaaggg   1320

aaatccatgc catatgagtt tgacatcagg gtcccgttct acgtgagggg ccccaacgtg   1380

gaagccggct gtctgaatcc ccacatcgtc ctcaacattg acctggcccc caccatcctg   1440

gacattgcag gcctggacat acctgcggat atggacggga aatccatcct caagctgctg   1500

gacacggagc ggccggtgaa tcggtttcac ttgaaaaaga agatgagggt ctggcgggac   1560

tccttcttgg tggagagagg caagctgcta cacaagagag acaatgacaa ggtggacgcc   1620

caggaggaga actttctgcc caagtaccag cgtgtgaagg acctgtgtca gcgtgctgag   1680

taccagacgg cgtgtgagca gctgggacag aagtggcagt gtgtggagga cgccacgggg   1740

aagctgaagc tgcataagtg caagggcccc atgcggctgg gcggcagcag agccctctcc   1800

aacctcgtgc ccaagtacta cgggcagggc agcgaggcct gcacctgtga cagcggggac   1860

tacaagctca gcctggccgg acgccggaaa aaactcttca agaagaagta caaggccagc   1920

tatgtccgca gtcgctccat ccgctcagtg gccatcgagg tggacggcag ggtgtaccac   1980

gtaggcctgg gtgatgccgc ccagccccga aacctcacca agcggcactg gccaggggcc   2040

cctgaggacc aagatgacaa ggatggtggg gacttcagtg gcactggagg ccttcccgac   2100

tactcagccg ccaaccccat taaagtgaca catcggtgct acatcctaga gaacgacaca   2160

gtccagtgtg acctggacct gtacaagtcc ctgcaggcct ggaaagacca caagctgcac   2220

atcgaccacg agattgaaac cctgcagaac aaaattaaga acctgaggga agtccgaggt   2280

cacctgaaga aaaagcggcc agaagaatgt gactgtcaca aaatcagcta ccacacccag   2340

cacaaaggcc gcctcaagca cagaggctcc agtctgcatc ctttcaggaa gggcctgcaa   2400

gagaaggaca aggtgtggct gttgcgggag cagaagcgca agaagaaact ccgcaagctg   2460

ctcaagcgcc tgcagaacaa cgacacgtgc agcatgccag gcctcacgtg cttcacccac   2520

gacaaccagc actggcagac ggcgcctttc tggacactgg ggcctttctg tgcctgcacc   2580

agcgccaaca ataacacgta ctggtgcatg aggaccatca atgagactca caatttcctc   2640

ttctgtgaat ttgcaactgg cttcctagag tactttgatc tcaacacaga cccctaccag   2700

ctgatgaatg cagtgaacac actggacagg gatgtcctca accagctaca cgtacagctc   2760

atggagctga ggagctgcaa gggttacaag cagtgtaacc cccggactcg aaacatggac   2820

ctgggactta aagatggagg aagctatgag caatacaggg gacaactgtg ggaaggctgg   2880

gaaggttaag aaacaacaga ggtggacctc caaaaacata gaggcatcac ctgactgcac   2940

aggcaatgaa aaaccatgtg ggtgatttcc agcagacctg tggtattggc caggaggcct   3000

gagaaagcaa gcacgcactc tcagtcaaca tgacagattc tggaggataa ccagcaggag   3060

cagagataac ttcaggaagt ccatttttgc ccctgctttt gctttggatt atacctcacc   3120

agctgcacaa aatgcatttt ttcgtatcaa aaagtcacca ctaaccctcc cccagaagct   3180

cacaaaggaa aacggagaga gcgagcgaga gagatttcct tggaaatttc tcccaagggc   3240

gaaagtcatt ggaattttta aatcataggg gaaaagcagt cctgttctaa atcctcttat   3300

tcttttggtt tgtcacaaag aaggaactaa gaagcaggac agaggcaacg tggagaggct   3360

gaaaacagtg cagagacgtt tgacaatgag tcagtagcac aaaagagatg acatttacct   3420

agcactataa accctggttg cctctgaaga aactgccttc attgtatata tgtgactatt   3480

tacatgtaat caacatggga acttttaggg gaacctaata agaaatccca attttcagga   3540

gtggtggtgt caataaacgc tctgtggcca gtgtaaaaga aaatccctcg cagttgtgga   3600

catttctgtt cctgtccaga taccatttct cctagtattt ctttgttatg tcccagaact   3660

gatgtttttt ttttaaggta ctgaaaagaa atgaagttga tgtatgtccc aagttttgat   3720

gaaactgtat ttgtaaaaaa aattttgtag tttaagtatt gtcatacagt gttcaaaacc   3780

ccagccaatg accagcagtt ggtatgaaga acctttgaca ttttgtaaaa ggccatttct   3840

tgg                                                                 3843


<210>  1281
<211>  852
<212>  PRT
<213>  Homo sapiens

<400>  1281

Met Gly Pro Pro Ser Leu Val Leu Cys Leu Leu Ser Ala Thr Val Phe 
1               5                   10                  15


Ser Leu Leu Gly Gly Ser Ser Ala Phe Leu Ser His His Arg Leu Lys 
            20                  25                  30


Gly Arg Phe Gln Arg Asp Arg Arg Asn Ile Arg Pro Asn Ile Ile Leu 
        35                  40                  45


Val Leu Thr Asp Asp Gln Asp Val Glu Leu Gly Ser Met Gln Val Met 
    50                  55                  60


Asn Lys Thr Arg Arg Ile Met Glu Gln Gly Gly Ala His Phe Ile Asn 
65                  70                  75                  80


Ala Phe Val Thr Thr Pro Met Cys Cys Pro Ser Arg Ser Ser Ile Leu 
                85                  90                  95


Thr Gly Lys Tyr Val His Asn His Asn Thr Tyr Thr Asn Asn Glu Asn 
            100                 105                 110


Cys Ser Ser Pro Ser Trp Gln Ala Gln His Glu Ser Arg Thr Phe Ala 
        115                 120                 125


Val Tyr Leu Asn Ser Thr Gly Tyr Arg Thr Ala Phe Phe Gly Lys Tyr 
    130                 135                 140


Leu Asn Glu Tyr Asn Gly Ser Tyr Val Pro Pro Gly Trp Lys Glu Trp 
145                 150                 155                 160


Val Gly Leu Leu Lys Asn Ser Arg Phe Tyr Asn Tyr Thr Leu Cys Arg 
                165                 170                 175


Asn Gly Val Lys Glu Lys His Gly Ser Asp Tyr Ser Lys Asp Tyr Leu 
            180                 185                 190


Thr Asp Leu Ile Thr Asn Asp Ser Val Ser Phe Phe Arg Thr Ser Lys 
        195                 200                 205


Lys Met Tyr Pro His Arg Pro Val Leu Met Val Ile Ser His Ala Ala 
    210                 215                 220


Pro His Gly Pro Glu Asp Ser Ala Pro Gln Tyr Ser Arg Leu Phe Pro 
225                 230                 235                 240


Asn Ala Ser Gln His Ile Thr Pro Ser Tyr Asn Tyr Ala Pro Asn Pro 
                245                 250                 255


Asp Lys His Trp Ile Met Arg Tyr Thr Gly Pro Met Lys Pro Ile His 
            260                 265                 270


Met Glu Phe Thr Asn Met Leu Gln Arg Lys Arg Leu Gln Thr Leu Met 
        275                 280                 285


Ser Val Asp Asp Ser Met Glu Thr Ile Tyr Asn Met Leu Val Glu Thr 
    290                 295                 300


Gly Glu Leu Asp Asn Thr Tyr Ile Val Tyr Thr Ala Asp His Gly Tyr 
305                 310                 315                 320


His Ile Gly Gln Phe Gly Leu Val Lys Gly Lys Ser Met Pro Tyr Glu 
                325                 330                 335


Phe Asp Ile Arg Val Pro Phe Tyr Val Arg Gly Pro Asn Val Glu Ala 
            340                 345                 350


Gly Cys Leu Asn Pro His Ile Val Leu Asn Ile Asp Leu Ala Pro Thr 
        355                 360                 365


Ile Leu Asp Ile Ala Gly Leu Asp Ile Pro Ala Asp Met Asp Gly Lys 
    370                 375                 380


Ser Ile Leu Lys Leu Leu Asp Thr Glu Arg Pro Val Asn Arg Phe His 
385                 390                 395                 400


Leu Lys Lys Lys Met Arg Val Trp Arg Asp Ser Phe Leu Val Glu Arg 
                405                 410                 415


Gly Lys Leu Leu His Lys Arg Asp Asn Asp Lys Val Asp Ala Gln Glu 
            420                 425                 430


Glu Asn Phe Leu Pro Lys Tyr Gln Arg Val Lys Asp Leu Cys Gln Arg 
        435                 440                 445


Ala Glu Tyr Gln Thr Ala Cys Glu Gln Leu Gly Gln Lys Trp Gln Cys 
    450                 455                 460


Val Glu Asp Ala Thr Gly Lys Leu Lys Leu His Lys Cys Lys Gly Pro 
465                 470                 475                 480


Met Arg Leu Gly Gly Ser Arg Ala Leu Ser Asn Leu Val Pro Lys Tyr 
                485                 490                 495


Tyr Gly Gln Gly Ser Glu Ala Cys Thr Cys Asp Ser Gly Asp Tyr Lys 
            500                 505                 510


Leu Ser Leu Ala Gly Arg Arg Lys Lys Leu Phe Lys Lys Lys Tyr Lys 
        515                 520                 525


Ala Ser Tyr Val Arg Ser Arg Ser Ile Arg Ser Val Ala Ile Glu Val 
    530                 535                 540


Asp Gly Arg Val Tyr His Val Gly Leu Gly Asp Ala Ala Gln Pro Arg 
545                 550                 555                 560


Asn Leu Thr Lys Arg His Trp Pro Gly Ala Pro Glu Asp Gln Asp Asp 
                565                 570                 575


Lys Asp Gly Gly Asp Phe Ser Gly Thr Gly Gly Leu Pro Asp Tyr Ser 
            580                 585                 590


Ala Ala Asn Pro Ile Lys Val Thr His Arg Cys Tyr Ile Leu Glu Asn 
        595                 600                 605


Asp Thr Val Gln Cys Asp Leu Asp Leu Tyr Lys Ser Leu Gln Ala Trp 
    610                 615                 620


Lys Asp His Lys Leu His Ile Asp His Glu Ile Glu Thr Leu Gln Asn 
625                 630                 635                 640


Lys Ile Lys Asn Leu Arg Glu Val Arg Gly His Leu Lys Lys Lys Arg 
                645                 650                 655


Pro Glu Glu Cys Asp Cys His Lys Ile Ser Tyr His Thr Gln His Lys 
            660                 665                 670


Gly Arg Leu Lys His Arg Gly Ser Ser Leu His Pro Phe Arg Lys Gly 
        675                 680                 685


Leu Gln Glu Lys Asp Lys Val Trp Leu Leu Arg Glu Gln Lys Arg Lys 
    690                 695                 700


Lys Lys Leu Arg Lys Leu Leu Lys Arg Leu Gln Asn Asn Asp Thr Cys 
705                 710                 715                 720


Ser Met Pro Gly Leu Thr Cys Phe Thr His Asp Asn Gln His Trp Gln 
                725                 730                 735


Thr Ala Pro Phe Trp Thr Leu Gly Pro Phe Cys Ala Cys Thr Ser Ala 
            740                 745                 750


Asn Asn Asn Thr Tyr Trp Cys Met Arg Thr Ile Asn Glu Thr His Asn 
        755                 760                 765


Phe Leu Phe Cys Glu Phe Ala Thr Gly Phe Leu Glu Tyr Phe Asp Leu 
    770                 775                 780


Asn Thr Asp Pro Tyr Gln Leu Met Asn Ala Val Asn Thr Leu Asp Arg 
785                 790                 795                 800


Asp Val Leu Asn Gln Leu His Val Gln Leu Met Glu Leu Arg Ser Cys 
                805                 810                 815


Lys Gly Tyr Lys Gln Cys Asn Pro Arg Thr Arg Asn Met Asp Leu Gly 
            820                 825                 830


Leu Lys Asp Gly Gly Ser Tyr Glu Gln Tyr Arg Gly Gln Leu Trp Glu 
        835                 840                 845


Gly Trp Glu Gly 
    850


<210>  1282
<211>  9004
<212>  DNA
<213>  Homo sapiens

<400>  1282
ggcggcgccg tggggccgag gtgtcgcttc ctgacggggc ggcgcggacg gacgcggccg     60

gtgccggccg ggacgccggg cccgcagcct agctcgccat ctcgctcacg ccgcccgccc    120

gcggggccgt cagcccccgc cgggccgggg ccatgcagga gagccagacc aagagcatgt    180

tcgtgtcccg ggccctggag aagatcctag ccgacaagga ggtgaagcgg ccccagcact    240

cccagctgcg cagggcctgc caggtggcgc tcgatgaaat taaagcagaa atagaaaagc    300

agaggcttgg cactgctgca ccaccaaagg caaacttcat tgaagctgac aagtattttc    360

ttccattcga gctagcttgc cagtccaagt ccccaagggt agtcagcaca tcccttgact    420

gcttgcagaa actcatcgca tacgggcaca tcactggcaa cgcccctgac agtggagccc    480

ctgggaagcg gctgatcgac agaattgttg aaaccatttg cagttgtttt cagggccctc    540

agactgatga aggggttcag ttacaaataa ttaaggctct tctgactgca gtgacttccc    600

cacacattga aattcatgag ggtactatcc tgcagacagt gagaacatgt tacaatatct    660

atttggccag caaaaatctc atcaatcaaa ccactgccaa ggctaccctt actcagatgc    720

tgaacgtcat tttcacccgc atggaaaacc aagtgttgca ggaggccaga gaactggaaa    780

aaccaatcca gtcaaaaccc cagtcccctg tgatccaagc tgcagcagta tccccaaagt    840

tcgttcgttt gaagcacagt caggcacaaa gcaaaccaac aactcccgaa aaaacagatt    900

taaccaacgg tgaacatgcc aggagtgatt ctggaaaagt aagcacagaa aatggagacg    960

cacccagaga aagaggctca tcactgtcag ggactgatga cggagcccag gaggtggtga   1020

aggacatctt ggaagatgta gtcacatctg ccattaaaga agcagcggaa aagcatggtc   1080

tgacagaacc tgagagagtt ctaggtgaac tggagtgcca ggaatgtgct attcccccag   1140

gagttgatga aaactcacag accaacggga tagccgatga caggcagtcc ttgtcgtcag   1200

cagataatct ggaatcggat gcacaaggac atcaagtggc tgccaggttc tcccacgttc   1260

tgcagaagga tgccttcctt gtgttccgct ccctgtgcaa gctgtccatg aaaccccttg   1320

gtgaaggccc tccagaccca aaatcccatg agctgcgttc caaggtggtt tccctgcagc   1380

tgctcctctc tgtgttgcaa aatgctggcc ccgtattcag gactcacgag atgttcatca   1440

atgcaatcaa gcaatatctc tgtgtggcct tgtccaaaaa cggcgtctct tcagtgcctg   1500

atgtctttga gctctctctt gccatttttc ttactcttct ttcaaacttt aaaatgcact   1560

tgaaaatgca gatagaggtc tttttcaaag agattttcct gaacatttta gaaacatcaa   1620

caagttcttt tgagcacagg tggatggtca ttcagactct gacgaggatc tgtgcagatg   1680

cccagtgtgt tgtggatatt tatgtcaact acgactgtga tttaaatgct gctaacattt   1740

ttgagcgcct tgtaaatgat ttatccaaaa ttgctcaggg aagaagtgga catgagctgg   1800

gaatgacacc tctgcaggag ctcagcctga ggaagaaagg cctggagtgc ctcgtgtcca   1860

ttctcaagtg catggtggag tggagcaaag acctgtatgt gaatcccaac caccagacca   1920

gcctcggtca ggagaggctc acggatcagg aaatagggga tgggaaaggc cttgacatgg   1980

caagacggtg tagtgtgacg tccatggagt ccacagtgtc ctcggggacc cagacaactg   2040

ttcaggatga ccctgagcaa tttgaggtca tcaagcaaca aaaagaaatc attgaacacg   2100

gcatcgagct gttcaacaag aaacccaaga gggggatcca gtttctccag gagcagggca   2160

tgctgggaac gtcagttgaa gacatagccc aattcctgca ccaggaggag cgcctggatt   2220

ccacccaagt aggcgatttt ctgggagata gcgcaaggtt caacaaggag gtgatgtatg   2280

cctacgtgga ccaacttgac ttctgtgaaa aagaatttgt ctcagccctg cggacattcc   2340

tagaaggttt ccgcctacct ggagaagccc aaaagattga ccgattaatg gagaagtttg   2400

ccgcaagata catagaatgc aaccaagggc aaactctgtt tgctagtgct gacactgctt   2460

atgtcctagc gtattcaatt attatgctga ctacagactt gcacagtcct caggtaaaaa   2520

ataaaatgac gaaagagcag tatattaaaa tgaatcgggg tatcaatgat agtaaagatc   2580

tgccagaaga gtatctctca agcatctatg aagagataga aggcaagaaa attgcaatga   2640

aagaaacaaa agagctaacg attgcaacca aatctactaa gcagaatgta gctagtgaaa   2700

agcagcggcg gctgctgtac aacttagaga tggagcaaat ggctaaaaca gccaaagctc   2760

tgatggaggc tgtgagccat gccaaagccc cgtttaccag tgccactcac ctggaccatg   2820

tccggccaat gttcaaactg gtgtggacgc cactattggc agcctacagc atcggactcc   2880

agaactgtga tgacactgaa gtggcctcct tgtgtttgga aggcatccga tgtgcaatcc   2940

gaatcgcctg catctttgga atgcagctgg aacgagatgc ctatgttcag gctcttgctc   3000

gcttctccct actcacagcc agctccagca tcacagaaat gaagcagaaa aacatcgaca   3060

ccattaagac gcttatcaca gtggctcaca ccgatggcaa ctaccttggg aattcctggc   3120

atgagatctt gaaatgcatc agccagctgg agctcgctca gctgatagga accggtgtga   3180

agacgcgcta cctgtctgga tctgggcgtg aaagagaagg gagcctgaag ggccacacat   3240

tggcaggaga agagttcatg ggccttggcc tcggtaattt ggtgagtggc ggagtggata   3300

aaagacagat ggccagcttc caagaatcgg ttggtgagac cagctcgcag agtgtggttg   3360

tagctgtgga caggattttt actgggtcta ccagactgga tggaaatgca atagttgact   3420

ttgtccgctg gctgtgtgct gtgtccatgg atgaactggc ttccccccac catcctcgca   3480

tgttcagctt gcagaagatt gtggagatat catactacaa catgaatcgg atccgactac   3540

agtggtctcg aatatggcat gtgattggag atcacttcaa taaggttggc tgcaacccta   3600

atgaagatgt ggctatcttt gctgttgact cattaaggca actctccatg aagtttcttg   3660

agaagggtga attagccaac ttccgtttcc agaaagattt tctgaggccc tttgagcata   3720

ttatgaagaa aaacaggtct cccaccatcc gggacatggc gatccgctgc attgcccaga   3780

tggtgaactc ccaggcggcc aacatccgct caggttggaa gaacatcttt gccgtgttcc   3840

accaggcagc ctctgatcat gatgggaaca ttgtggagct ggccttccag accacttgcc   3900

acattgtcac aactattttc cagcaccatt ttcctgcagc catcgattcc tttcaggatg   3960

ctgtgaagtg cttatcagag ttcgcctgca acgccgcttt ccctgacacg agcatggaag   4020

cgattcggct catccgcttc tgtggcaaat acgtctctga gaggcctcgg gtgctacaag   4080

aatacacaag tgatgacatg aatgtagctc ctggtgacag agtctgggtc cgaggctggt   4140

tccccatctt attcgaactc tcctgcatca ttaatagatg caagttagat gtacgaacaa   4200

ggggactcac agtcatgttt gagatcatga agagctatgg ccacaccttt gaaaagcact   4260

ggtggcagga cctgttcaga atcgtgtttc ggatttttga caatatgaaa ctccctgagc   4320

aactgtcaga gaaatctgag tggatgacaa caacctgcaa tcacgcactt tatgctattt   4380

gtgatgtttt tacccagttt tatgaagctt tgaatgaagt tcttctttct gatgtatttg   4440

cacaattgca gtggtgtgtc aaacaagata atgaacagtt ggcgcgatca ggtacaaatt   4500

gcttagaaaa cttagtaata tccaatggag agaaattcag tcctgaagtc tgggatgaaa   4560

cctgcaactg tatgttggat attttcaaaa caaccatccc acatgttttg ctgacatgga   4620

gacctgtagg aatggaggaa gattcatcag aaaagcattt ggatgtggat ctggaccgcc   4680

agtctttaag cagcatagat aaaaatccct ctgagagggg acagagccag ctctctaacc   4740

caacagatga cagctggaag ggtagaccat acgcaaatca gaaactgttt gccagcctcc   4800

tcatcaagtg tgtggtccag ttggaattga tacagaccat tgacaacatt gtgttctacc   4860

ctgcgacgag caaaaaggag gatgcagagc acatggttgc cgcccagcaa gacacgctgg   4920

atgcagatat ccacatagag acggaggatc agggcatgta taagtacatg tcttcccagc   4980

acctcttcaa gctgttggac tgtttgcagg aatcccattc attctcaaag gccttcaact   5040

ccaattacga gcagcggact gtcctgtggc gagcaggttt taagggcaag tctaaaccca   5100

atcttctaaa acaagaaacc agcagcctgg cctgttgttt gaggatcctg tttcgaatgt   5160

atgttgatga gaaccgcagg gattcctggg aagaaataca gcagagactt ttaactgttt   5220

gcagtgaagc tcttgcctat ttcatcactg tgaattctga gagccatcgg gaggcctgga   5280

caagtctctt gttgttactt ctaactaaaa ccctcaaaat aaatgatgaa aagttcaaag   5340

cacatgcttc aatgtactac ccctacttgt gtgaaattat gcagtttgac ctgatccctg   5400

agctccgagc agttctgcgg aagttcttcc tacggatagg tgttgtgtat aagatatgga   5460

taccagaaga gccatcacag gtaccagcag cactgtcacc agtgtggtag ccctggctgc   5520

ccaggccagt gctgcagctc tgcagaatgt tcagcatgcc atttctgact ggcacatctc   5580

gtgaagtttc atagaaacaa ggagttggca tcttggatct cagaatggcc tggaaacgga   5640

tggcctctac gctgttccat cacagtctcc aactaaggct tatggtattt cattaaactg   5700

ttgcataccc agttagcaca gtaggtgggg agtctgcttc atttctatca ttccattttt   5760

ctgattaaac tgtcaaatct gtcattgcat atgccatcgt tttctagcaa aatcccatga   5820

ttggctataa acgttttgta agaagtcact ctccttgaaa atactgaaca tagctgtata   5880

ggtttgtgat tattagagaa tatgttaata aaacttcttg taacggctaa ctgccaccta   5940

aaatatgctg ggttttctgt tgtttgagtg tgttagagaa atttgaatgt ttttgtcagt   6000

tacgagtcag ccgtaattag attagtttaa ggacaggtca ggattagaga agagttgttt   6060

ttgtgttttg ttaatgtctg agtgattttt aaagtatttt acaaaaagat attgaaaatt   6120

tggttgaagg cagagtttag taattaagtt agaattaaga gttttgcgag gttaaaaaaa   6180

tgtgcctcgt ggatctccct gttttagtaa catggagaga aaaagtctac acgaaaaagt   6240

gaacaattta atgaagatga ttagccttcc ttgaaataag tatttgtgga tgggtgttaa   6300

attaaaattt ccagaataca ctgtccatct cacacactct gaaatctaat atatgaagta   6360

gtaatgaaaa tgaagtagta atttaaccag agttcattta tccttgaata aaccttttta   6420

ttttcacctc agaaaagtga gtgtactggc agttagtgtc actgctttgc acagtcccca   6480

ttaaaggacc ctccagagag ggacagtaac tgtgcatgag aagccgctcc cataagcctc   6540

ctcagccaga tgtcatgggt ggaactggag ctgtgtcggg gccagcacag ctgaactgtg   6600

acaatggcag gaggtggcat gtgcccagca cttccattaa tctgagccta ggagttgaat   6660

tctttggcaa ggttggattc tgaggtcctt attatgttaa tgatggtgca atactctcac   6720

ctgcagtaga actgagttct gctgcagctt gtgtaaaagt gggcagtaca caagtacgtc   6780

ccaaagcctg tgagcagtat acgtggatgc tcacccatga gaaggagcac acacgcctca   6840

ttctctgccc tcacccactg ctcacctaga gcatcgctga gcgttagaca aagtgttaca   6900

cagaatgatt aaaactttca gacttctacc tatgctcttt agtcctgtaa attgggttgt   6960

attgatgtca actctggtgc cttagaagtt agtagtttgg gaacctatct gtaaaatcag   7020

atgttttttc tttgtagaga aggatttctg gtgcttttgc ttactaagag accgatattc   7080

ttaagttgtt ttcttgtttt aacagccttg agaaatgttt ggttttggcc agcagaattc   7140

ttgtctactt ttttctttcc caaaaagtgt tttttaattt ctctaccaaa gaaaaaatga   7200

gcaggtttag gtttttacat gacttatata cattagataa aaggagctgt ataatttagc   7260

aggaagggac tatgggagaa tactttactg tgagtggaaa atgttagcac atttgactgg   7320

tttgccctgg aatccactgc acctttacac tgcaccatga aacctacact ccctggtatc   7380

atagcgcgtc atcacctcaa caagtcagtc gtctccattg atatttgtac aaaaggtata   7440

catggggaac acgtgttcat tcattaagtc catcttgcgt gcagctatat ccctgattgg   7500

ttatttttcc tttccttctg aggttctcat gtcattttct tcatcggatg tgactaaaat   7560

ttttctggtg tcttctgccc tctctttaat tttgcctctt gaggggtagc agatgtgtca   7620

gtgcatttta ttacttgctg aaacattcag gcttacattt cttattagtt tagtatttta   7680

aaagatttaa ttttctgaat gaggcatttg aattgtacca gcaatggact tttaaaaaat   7740

tggatgtaaa accattcagg gtgatttttc ttgtcagtgg acagtgacga acagagattt   7800

gaaatccctt acctccaata ataagccatt cagcctaaat tcatttttat gaataaatct   7860

cttctttctc atggtaaatg tggcttgtgc cactcaaaca ctagtgaaag ggtatgtaca   7920

accgcaacat caggccagga caccatttat ttaaccaagt aatggaggag agtgaaacat   7980

tttccaaggc cttatttctt tttcagaatg ctttaagtgt tgattatatg tgctgggtct   8040

ctagagaagt ttttatttgt tacaatactg ctgctttgag caattttgtt tctcttcatt   8100

gtctgttagg gaaatcacca gctttggcat cttaacaaca aacagtggat gggtaatttt   8160

tatttctgat acgcatcttt agagtcaaat atatcttttc cctgtactcc tcatgtacaa   8220

ccaaagaaca tacattatga aaattgtatt ataatatctg gaaacacaac attttcctct   8280

ggcaggtgac ttttgtacga aatgaaaaaa aaaaaacctg tatttttttt gttgttcttt   8340

tgtgattaag gatatacatt tagtagtctt tgttattaaa ggaacctgct gataagtaca   8400

agtgtgacca tctcattcaa atgtttgttg ttatgatgca aatggatatt ggtttcaata   8460

gaagctggat ccttaatact gcattttctg aattctgttt taatatttgt gttaaagtag   8520

acatagctga actcacatgg aatcctggag ttttgttatc agcagctttg cagtttggga   8580

aacaaagaaa ccaaagctga gtgttttaaa gaatgaacat atctggaaat ccttgctctc   8640

aaaacaaaac aatataatct atcaaaggtg ttttactcag tgttctaatt tttaaaaaat   8700

tttatctgca tatttgcatc aaatatttat gtgtaaaatg tatgttttac ctccttaaaa   8760

tgcctaaaag ttagttaata gttactttgg tttaacctat acacaatgat taagtgcatt   8820

taatattggt aatttaatga aaaccattcc ttgcccaatg gatgtataaa tttttgaaag   8880

aataagcaga attatataat atgaaatgct atgtaaagtt ttctatgtaa aaatattatg   8940

tataatacta ttaaaatatc ccatgctttg atcaggtggt acatcaataa aattttaaaa   9000

agta                                                                9004


<210>  1283
<211>  1785
<212>  PRT
<213>  Homo sapiens

<400>  1283

Met Gln Glu Ser Gln Thr Lys Ser Met Phe Val Ser Arg Ala Leu Glu 
1               5                   10                  15


Lys Ile Leu Ala Asp Lys Glu Val Lys Arg Pro Gln His Ser Gln Leu 
            20                  25                  30


Arg Arg Ala Cys Gln Val Ala Leu Asp Glu Ile Lys Ala Glu Ile Glu 
        35                  40                  45


Lys Gln Arg Leu Gly Thr Ala Ala Pro Pro Lys Ala Asn Phe Ile Glu 
    50                  55                  60


Ala Asp Lys Tyr Phe Leu Pro Phe Glu Leu Ala Cys Gln Ser Lys Ser 
65                  70                  75                  80


Pro Arg Val Val Ser Thr Ser Leu Asp Cys Leu Gln Lys Leu Ile Ala 
                85                  90                  95


Tyr Gly His Ile Thr Gly Asn Ala Pro Asp Ser Gly Ala Pro Gly Lys 
            100                 105                 110


Arg Leu Ile Asp Arg Ile Val Glu Thr Ile Cys Ser Cys Phe Gln Gly 
        115                 120                 125


Pro Gln Thr Asp Glu Gly Val Gln Leu Gln Ile Ile Lys Ala Leu Leu 
    130                 135                 140


Thr Ala Val Thr Ser Pro His Ile Glu Ile His Glu Gly Thr Ile Leu 
145                 150                 155                 160


Gln Thr Val Arg Thr Cys Tyr Asn Ile Tyr Leu Ala Ser Lys Asn Leu 
                165                 170                 175


Ile Asn Gln Thr Thr Ala Lys Ala Thr Leu Thr Gln Met Leu Asn Val 
            180                 185                 190


Ile Phe Thr Arg Met Glu Asn Gln Val Leu Gln Glu Ala Arg Glu Leu 
        195                 200                 205


Glu Lys Pro Ile Gln Ser Lys Pro Gln Ser Pro Val Ile Gln Ala Ala 
    210                 215                 220


Ala Val Ser Pro Lys Phe Val Arg Leu Lys His Ser Gln Ala Gln Ser 
225                 230                 235                 240


Lys Pro Thr Thr Pro Glu Lys Thr Asp Leu Thr Asn Gly Glu His Ala 
                245                 250                 255


Arg Ser Asp Ser Gly Lys Val Ser Thr Glu Asn Gly Asp Ala Pro Arg 
            260                 265                 270


Glu Arg Gly Ser Ser Leu Ser Gly Thr Asp Asp Gly Ala Gln Glu Val 
        275                 280                 285


Val Lys Asp Ile Leu Glu Asp Val Val Thr Ser Ala Ile Lys Glu Ala 
    290                 295                 300


Ala Glu Lys His Gly Leu Thr Glu Pro Glu Arg Val Leu Gly Glu Leu 
305                 310                 315                 320


Glu Cys Gln Glu Cys Ala Ile Pro Pro Gly Val Asp Glu Asn Ser Gln 
                325                 330                 335


Thr Asn Gly Ile Ala Asp Asp Arg Gln Ser Leu Ser Ser Ala Asp Asn 
            340                 345                 350


Leu Glu Ser Asp Ala Gln Gly His Gln Val Ala Ala Arg Phe Ser His 
        355                 360                 365


Val Leu Gln Lys Asp Ala Phe Leu Val Phe Arg Ser Leu Cys Lys Leu 
    370                 375                 380


Ser Met Lys Pro Leu Gly Glu Gly Pro Pro Asp Pro Lys Ser His Glu 
385                 390                 395                 400


Leu Arg Ser Lys Val Val Ser Leu Gln Leu Leu Leu Ser Val Leu Gln 
                405                 410                 415


Asn Ala Gly Pro Val Phe Arg Thr His Glu Met Phe Ile Asn Ala Ile 
            420                 425                 430


Lys Gln Tyr Leu Cys Val Ala Leu Ser Lys Asn Gly Val Ser Ser Val 
        435                 440                 445


Pro Asp Val Phe Glu Leu Ser Leu Ala Ile Phe Leu Thr Leu Leu Ser 
    450                 455                 460


Asn Phe Lys Met His Leu Lys Met Gln Ile Glu Val Phe Phe Lys Glu 
465                 470                 475                 480


Ile Phe Leu Asn Ile Leu Glu Thr Ser Thr Ser Ser Phe Glu His Arg 
                485                 490                 495


Trp Met Val Ile Gln Thr Leu Thr Arg Ile Cys Ala Asp Ala Gln Cys 
            500                 505                 510


Val Val Asp Ile Tyr Val Asn Tyr Asp Cys Asp Leu Asn Ala Ala Asn 
        515                 520                 525


Ile Phe Glu Arg Leu Val Asn Asp Leu Ser Lys Ile Ala Gln Gly Arg 
    530                 535                 540


Ser Gly His Glu Leu Gly Met Thr Pro Leu Gln Glu Leu Ser Leu Arg 
545                 550                 555                 560


Lys Lys Gly Leu Glu Cys Leu Val Ser Ile Leu Lys Cys Met Val Glu 
                565                 570                 575


Trp Ser Lys Asp Leu Tyr Val Asn Pro Asn His Gln Thr Ser Leu Gly 
            580                 585                 590


Gln Glu Arg Leu Thr Asp Gln Glu Ile Gly Asp Gly Lys Gly Leu Asp 
        595                 600                 605


Met Ala Arg Arg Cys Ser Val Thr Ser Met Glu Ser Thr Val Ser Ser 
    610                 615                 620


Gly Thr Gln Thr Thr Val Gln Asp Asp Pro Glu Gln Phe Glu Val Ile 
625                 630                 635                 640


Lys Gln Gln Lys Glu Ile Ile Glu His Gly Ile Glu Leu Phe Asn Lys 
                645                 650                 655


Lys Pro Lys Arg Gly Ile Gln Phe Leu Gln Glu Gln Gly Met Leu Gly 
            660                 665                 670


Thr Ser Val Glu Asp Ile Ala Gln Phe Leu His Gln Glu Glu Arg Leu 
        675                 680                 685


Asp Ser Thr Gln Val Gly Asp Phe Leu Gly Asp Ser Ala Arg Phe Asn 
    690                 695                 700


Lys Glu Val Met Tyr Ala Tyr Val Asp Gln Leu Asp Phe Cys Glu Lys 
705                 710                 715                 720


Glu Phe Val Ser Ala Leu Arg Thr Phe Leu Glu Gly Phe Arg Leu Pro 
                725                 730                 735


Gly Glu Ala Gln Lys Ile Asp Arg Leu Met Glu Lys Phe Ala Ala Arg 
            740                 745                 750


Tyr Ile Glu Cys Asn Gln Gly Gln Thr Leu Phe Ala Ser Ala Asp Thr 
        755                 760                 765


Ala Tyr Val Leu Ala Tyr Ser Ile Ile Met Leu Thr Thr Asp Leu His 
    770                 775                 780


Ser Pro Gln Val Lys Asn Lys Met Thr Lys Glu Gln Tyr Ile Lys Met 
785                 790                 795                 800


Asn Arg Gly Ile Asn Asp Ser Lys Asp Leu Pro Glu Glu Tyr Leu Ser 
                805                 810                 815


Ser Ile Tyr Glu Glu Ile Glu Gly Lys Lys Ile Ala Met Lys Glu Thr 
            820                 825                 830


Lys Glu Leu Thr Ile Ala Thr Lys Ser Thr Lys Gln Asn Val Ala Ser 
        835                 840                 845


Glu Lys Gln Arg Arg Leu Leu Tyr Asn Leu Glu Met Glu Gln Met Ala 
    850                 855                 860


Lys Thr Ala Lys Ala Leu Met Glu Ala Val Ser His Ala Lys Ala Pro 
865                 870                 875                 880


Phe Thr Ser Ala Thr His Leu Asp His Val Arg Pro Met Phe Lys Leu 
                885                 890                 895


Val Trp Thr Pro Leu Leu Ala Ala Tyr Ser Ile Gly Leu Gln Asn Cys 
            900                 905                 910


Asp Asp Thr Glu Val Ala Ser Leu Cys Leu Glu Gly Ile Arg Cys Ala 
        915                 920                 925


Ile Arg Ile Ala Cys Ile Phe Gly Met Gln Leu Glu Arg Asp Ala Tyr 
    930                 935                 940


Val Gln Ala Leu Ala Arg Phe Ser Leu Leu Thr Ala Ser Ser Ser Ile 
945                 950                 955                 960


Thr Glu Met Lys Gln Lys Asn Ile Asp Thr Ile Lys Thr Leu Ile Thr 
                965                 970                 975


Val Ala His Thr Asp Gly Asn Tyr Leu Gly Asn Ser Trp His Glu Ile 
            980                 985                 990


Leu Lys Cys Ile Ser Gln Leu Glu Leu Ala Gln Leu Ile Gly Thr Gly 
        995                 1000                1005


Val Lys Thr Arg Tyr Leu Ser Gly Ser Gly Arg Glu Arg Glu Gly Ser 
    1010                1015                1020


Leu Lys Gly His Thr Leu Ala Gly Glu Glu Phe Met Gly Leu Gly Leu 
1025                1030                1035                1040


Gly Asn Leu Val Ser Gly Gly Val Asp Lys Arg Gln Met Ala Ser Phe 
                1045                1050                1055


Gln Glu Ser Val Gly Glu Thr Ser Ser Gln Ser Val Val Val Ala Val 
            1060                1065                1070


Asp Arg Ile Phe Thr Gly Ser Thr Arg Leu Asp Gly Asn Ala Ile Val 
        1075                1080                1085


Asp Phe Val Arg Trp Leu Cys Ala Val Ser Met Asp Glu Leu Ala Ser 
    1090                1095                1100


Pro His His Pro Arg Met Phe Ser Leu Gln Lys Ile Val Glu Ile Ser 
1105                1110                1115                1120


Tyr Tyr Asn Met Asn Arg Ile Arg Leu Gln Trp Ser Arg Ile Trp His 
                1125                1130                1135


Val Ile Gly Asp His Phe Asn Lys Val Gly Cys Asn Pro Asn Glu Asp 
            1140                1145                1150


Val Ala Ile Phe Ala Val Asp Ser Leu Arg Gln Leu Ser Met Lys Phe 
        1155                1160                1165


Leu Glu Lys Gly Glu Leu Ala Asn Phe Arg Phe Gln Lys Asp Phe Leu 
    1170                1175                1180


Arg Pro Phe Glu His Ile Met Lys Lys Asn Arg Ser Pro Thr Ile Arg 
1185                1190                1195                1200


Asp Met Ala Ile Arg Cys Ile Ala Gln Met Val Asn Ser Gln Ala Ala 
                1205                1210                1215


Asn Ile Arg Ser Gly Trp Lys Asn Ile Phe Ala Val Phe His Gln Ala 
            1220                1225                1230


Ala Ser Asp His Asp Gly Asn Ile Val Glu Leu Ala Phe Gln Thr Thr 
        1235                1240                1245


Cys His Ile Val Thr Thr Ile Phe Gln His His Phe Pro Ala Ala Ile 
    1250                1255                1260


Asp Ser Phe Gln Asp Ala Val Lys Cys Leu Ser Glu Phe Ala Cys Asn 
1265                1270                1275                1280


Ala Ala Phe Pro Asp Thr Ser Met Glu Ala Ile Arg Leu Ile Arg Phe 
                1285                1290                1295


Cys Gly Lys Tyr Val Ser Glu Arg Pro Arg Val Leu Gln Glu Tyr Thr 
            1300                1305                1310


Ser Asp Asp Met Asn Val Ala Pro Gly Asp Arg Val Trp Val Arg Gly 
        1315                1320                1325


Trp Phe Pro Ile Leu Phe Glu Leu Ser Cys Ile Ile Asn Arg Cys Lys 
    1330                1335                1340


Leu Asp Val Arg Thr Arg Gly Leu Thr Val Met Phe Glu Ile Met Lys 
1345                1350                1355                1360


Ser Tyr Gly His Thr Phe Glu Lys His Trp Trp Gln Asp Leu Phe Arg 
                1365                1370                1375


Ile Val Phe Arg Ile Phe Asp Asn Met Lys Leu Pro Glu Gln Leu Ser 
            1380                1385                1390


Glu Lys Ser Glu Trp Met Thr Thr Thr Cys Asn His Ala Leu Tyr Ala 
        1395                1400                1405


Ile Cys Asp Val Phe Thr Gln Phe Tyr Glu Ala Leu Asn Glu Val Leu 
    1410                1415                1420


Leu Ser Asp Val Phe Ala Gln Leu Gln Trp Cys Val Lys Gln Asp Asn 
1425                1430                1435                1440


Glu Gln Leu Ala Arg Ser Gly Thr Asn Cys Leu Glu Asn Leu Val Ile 
                1445                1450                1455


Ser Asn Gly Glu Lys Phe Ser Pro Glu Val Trp Asp Glu Thr Cys Asn 
            1460                1465                1470


Cys Met Leu Asp Ile Phe Lys Thr Thr Ile Pro His Val Leu Leu Thr 
        1475                1480                1485


Trp Arg Pro Val Gly Met Glu Glu Asp Ser Ser Glu Lys His Leu Asp 
    1490                1495                1500


Val Asp Leu Asp Arg Gln Ser Leu Ser Ser Ile Asp Lys Asn Pro Ser 
1505                1510                1515                1520


Glu Arg Gly Gln Ser Gln Leu Ser Asn Pro Thr Asp Asp Ser Trp Lys 
                1525                1530                1535


Gly Arg Pro Tyr Ala Asn Gln Lys Leu Phe Ala Ser Leu Leu Ile Lys 
            1540                1545                1550


Cys Val Val Gln Leu Glu Leu Ile Gln Thr Ile Asp Asn Ile Val Phe 
        1555                1560                1565


Tyr Pro Ala Thr Ser Lys Lys Glu Asp Ala Glu His Met Val Ala Ala 
    1570                1575                1580


Gln Gln Asp Thr Leu Asp Ala Asp Ile His Ile Glu Thr Glu Asp Gln 
1585                1590                1595                1600


Gly Met Tyr Lys Tyr Met Ser Ser Gln His Leu Phe Lys Leu Leu Asp 
                1605                1610                1615


Cys Leu Gln Glu Ser His Ser Phe Ser Lys Ala Phe Asn Ser Asn Tyr 
            1620                1625                1630


Glu Gln Arg Thr Val Leu Trp Arg Ala Gly Phe Lys Gly Lys Ser Lys 
        1635                1640                1645


Pro Asn Leu Leu Lys Gln Glu Thr Ser Ser Leu Ala Cys Cys Leu Arg 
    1650                1655                1660


Ile Leu Phe Arg Met Tyr Val Asp Glu Asn Arg Arg Asp Ser Trp Glu 
1665                1670                1675                1680


Glu Ile Gln Gln Arg Leu Leu Thr Val Cys Ser Glu Ala Leu Ala Tyr 
                1685                1690                1695


Phe Ile Thr Val Asn Ser Glu Ser His Arg Glu Ala Trp Thr Ser Leu 
            1700                1705                1710


Leu Leu Leu Leu Leu Thr Lys Thr Leu Lys Ile Asn Asp Glu Lys Phe 
        1715                1720                1725


Lys Ala His Ala Ser Met Tyr Tyr Pro Tyr Leu Cys Glu Ile Met Gln 
    1730                1735                1740


Phe Asp Leu Ile Pro Glu Leu Arg Ala Val Leu Arg Lys Phe Phe Leu 
1745                1750                1755                1760


Arg Ile Gly Val Val Tyr Lys Ile Trp Ile Pro Glu Glu Pro Ser Gln 
                1765                1770                1775


Val Pro Ala Ala Leu Ser Pro Val Trp 
            1780                1785


<210>  1284
<211>  4352
<212>  DNA
<213>  Homo sapiens

<400>  1284
ggaggagttt gttaatgttc agtttgttca gcgggatcga tgtttgctgg catcgcctcg     60

ccctgtcttg tgtgtgtgtg cgagggtgtg tgtgtgtgtt tgtgtgtgtg tgcatatgtg    120

gggggtgtga gtgtgtgtgt gcgaggaagc gggggtgcgt gcgcgtgtga gtgcgtgtgt    180

gagtgtctgt gtgtgtgtct gtgtgtgtgt gtgagtgagt gaattccaga ttttctgtct    240

ttccaaaacc cgctcctgtc ctctcgcata tcactcacag acggggatct gacagcagcc    300

acaaacctac agtgagtgat cgctctcccc ccggcacgaa tccgccatag agatcggcga    360

ggaggaggag gaggaggagg aagaaaagaa ggaggaggtg gaggaggagg tggaggagga    420

ggaggaggag ggaaagagga gaaggaagaa gaagaaaaag aagaaaccca ctaccttccc    480

aggattgcct tttttttttc cttatcttta cgcgcgagtg tgcctgtggc gcgtgtgcgc    540

ccctcgtccc ttccatccga acccgggctt ggatgtttaa taaagaaatc aagtgtctca    600

acagtcacca aaaaaaaaaa aaaccgcaaa aacaaaacca aaaaaattcc aaaagcaaaa    660

acaaaaaaga gagaggaaaa aaaattcaaa ataaacaaac aaacaaacaa ggcagaacca    720

acctctactt caaagcagcc ggcacaagcc acccgtgtct gccacccaga gaggggggtc    780

tctggcccgt ggtggaggag ttgcaggggg gatcgtcagg gggacagagg ccgagtgacg    840

tcctaggagc caccgggcaa gaggcggagg agacccagag aggccagaga gacagcgggc    900

cccagcgcgc ggctcggggc tggggcgcca gaagtgggac tggagcgaag tagaggatgc    960

cgaggagaaa acagcaggca cccaagcggg cggcaggcta cgcccaggag gaacagctga   1020

aagaagagga ggaaataaaa gaagaggagg aggaggagga cagcggttca gtagctcaac   1080

tgcagggtgg caatgacaca gggacggacg aggagctaga aacgggccca gagcaaaaag   1140

gctgcttcag ctaccagaac tctccaggaa gtcatttgtc caatcaggat gccgagaacg   1200

agtctctgct gagtgacgcc agtgatcagg tgtcggacat caagagtgtc tgcggcagag   1260

atgcctcaga caagaaagca cacactcacg tcaggcttcc aaacgaagca cacaattgca   1320

tggataaaat gaccgctgtc tacgccaaca tcctgtcgga ttcctactgg tcaggcctgg   1380

gccttggctt caagctgtcc aatagtgaga ggaggaactg tgacacccga aacggcagca   1440

acaagagtga ttttgattgg caccaagacg ctctgtccaa aagcctgcag cagaacttgc   1500

cttctcggtc cgtctcgaaa cccagcctgt tcagctcggt gcagttgtac cgacagagca   1560

gcaagatgtg cgggactgtg ttcacagggg ccagcagatt ccgatgccga cagtgcagcg   1620

cggcctatga caccctagtc gagctgactg tgcacatgaa tgaaacgggc cactatcaag   1680

atgacaaccg caaaaaggac aagctcagac ccacgagcta ttcaaagccc aggaaaaggg   1740

ctttccagga tatggacaaa gaggatgctc aaaaggttct gaaatgtatg ttttgtggcg   1800

actcctttga ttccctccaa gatttgagcg tccacatgat taaaacaaaa cattaccaaa   1860

aagtgccttt gaaggagcca gtcccaacca tttcctcgaa aatggtcacc ccggctaaga   1920

aacgcgtttt tgatgtcaat cggccgtgtt cccccgattc aaccacagga tcttttgcag   1980

attctttttc ttctcagaag aacgccaact tgcagttgtc ctccaacaac cgctatggct   2040

accaaaatgg agccagctac acctggcagt ttgaggcctg caagtcccag atcttaaagt   2100

gcatggagtg tgggagctcc catgacacct tgcagcagct caccacccac atgatggtca   2160

caggtcactt tctcaaggtc accagctctg cctccaagaa agggaagcag ctggtattag   2220

acccgttagc agtggagaaa atgcagtcgt tgtctgaggc cccaaacagt gattctctgg   2280

ctcccaagcc atccagtaac tcagcatcag attgtacagc ctctacaact gagttaaaga   2340

aagagagtaa aaaagaaagg ccagaggaaa ccagcaagga tgagaaagtc gtgaaaagcg   2400

aggactatga agatcctcta caaaaacctt tagaccctac aatcaaatat caatacctaa   2460

gggaggaaga cttggaagat ggctcaaagg gtggagggga cattttgaaa tctttggaaa   2520

atactgtcac cacagccatc aacaaagccc aaaacggggc ccccagctgg agtgcctacc   2580

ccagcatcca cgcagcctac cagctgtctg agggcaccaa gccgcctttg cctatgggat   2640

cccaggtact gcagatccgg cctaatctca ccaacaagct gaggcccatt gcaccaaagt   2700

ggaaagtgat gccactggtt tctatgccca cacacctggc cccttacact caagtcaaga   2760

aagagtcaga agacaaagat gaagcggtga aggagtgtgg gaaagaaagt ccccacgaag   2820

aggcctcatc tttcagccac agtgagggcg attctttccg caaaagtgaa acacctccag   2880

aagccaaaaa gaccgagctg ggtcccctga aggaggagga gaagctgatg aaagagggca   2940

gcgagaagga gaaaccccag cccctggagc ccacatctgc tctgagcaat gggtgcgccc   3000

tcgccaacca cgccccggcc ctgccatgca tcaacccact cagcgccctg cagtccgtcc   3060

tgaacaatca cttgggcaaa gccacggagc ccttgcgctc accttcctgc tccagcccaa   3120

gttcaagcac aatttccatg ttccacaagt cgaatctcaa tgtcatggac aagccggtct   3180

tgagtcctgc ctccacaagg tcagccagcg tgtccaggcg ctacctgttt gagaacagcg   3240

atcagcccat tgacctgacc aagtccaaaa gcaagaaagc cgagtcctcg caagcacaat   3300

cttgtatgtc cccacctcag aagcacgctc tgtctgacat cgccgacatg gtcaaagtcc   3360

tccccaaagc caccacccca aagccagcct cctcctccag ggtccccccc atgaagctgg   3420

aaatggatgt caggcgcttt gaggatgtct ccagtgaagt ctcaactttg cataaaagaa   3480

aaggccggca gtccaactgg aatcctcagc atcttctgat tctacaagcc cagtttgcct   3540

cgagcctctt ccagacatca gagggcaaat acctgctgtc tgatctgggc ccacaagagc   3600

gtatgcaaat ctctaagttt acgggactct caatgaccac tatcagtcac tggctggcca   3660

acgtcaagta ccagcttagg aaaacgggcg ggacaaaatt tctgaaaaac atggacaaag   3720

gccaccccat cttttattgc agtgactgtg cctcccagtt cagaacccct tctacctaca   3780

tcagtcactt agaatctcac ctgggtttcc aaatgaagga catgacccgc ttgtcagtgg   3840

accagcaaag caaggtggag caagagatct cccgggtatc gtcggctcag aggtctccag   3900

aaacaatagc tgccgaagag gacacagact ctaaattcaa gtgtaagttg tgctgtcgga   3960

catttgtgag caaacatgcg gtaaaactcc acctaagcaa aacgcacagc aagtcacccg   4020

aacaccattc acagtttgta acagacgtgg atgaagaata gctctgcagg acgaatgcct   4080

tagtttccac tttccagcct ggatcccctc acactgaacc cttcttcgtt gcaccatcct   4140

gcttctgaca ttgaactcat tgaactcctc ctgacaccct ggctctgaga agactgccaa   4200

aaaaaaaaaa aaaaaaaaat caccccagcc atttctcttc atcctcacta acaatttggt   4260

aatgaagtat tgatttccac ttctctgctt atgggcggta ttagattttc attgataaat   4320

tgcaatgggg ctgtctcgtc tccacagtac cc                                 4352


<210>  1285
<211>  1034
<212>  PRT
<213>  Homo sapiens

<400>  1285

Met Pro Arg Arg Lys Gln Gln Ala Pro Lys Arg Ala Ala Gly Tyr Ala 
1               5                   10                  15


Gln Glu Glu Gln Leu Lys Glu Glu Glu Glu Ile Lys Glu Glu Glu Glu 
            20                  25                  30


Glu Glu Asp Ser Gly Ser Val Ala Gln Leu Gln Gly Gly Asn Asp Thr 
        35                  40                  45


Gly Thr Asp Glu Glu Leu Glu Thr Gly Pro Glu Gln Lys Gly Cys Phe 
    50                  55                  60


Ser Tyr Gln Asn Ser Pro Gly Ser His Leu Ser Asn Gln Asp Ala Glu 
65                  70                  75                  80


Asn Glu Ser Leu Leu Ser Asp Ala Ser Asp Gln Val Ser Asp Ile Lys 
                85                  90                  95


Ser Val Cys Gly Arg Asp Ala Ser Asp Lys Lys Ala His Thr His Val 
            100                 105                 110


Arg Leu Pro Asn Glu Ala His Asn Cys Met Asp Lys Met Thr Ala Val 
        115                 120                 125


Tyr Ala Asn Ile Leu Ser Asp Ser Tyr Trp Ser Gly Leu Gly Leu Gly 
    130                 135                 140


Phe Lys Leu Ser Asn Ser Glu Arg Arg Asn Cys Asp Thr Arg Asn Gly 
145                 150                 155                 160


Ser Asn Lys Ser Asp Phe Asp Trp His Gln Asp Ala Leu Ser Lys Ser 
                165                 170                 175


Leu Gln Gln Asn Leu Pro Ser Arg Ser Val Ser Lys Pro Ser Leu Phe 
            180                 185                 190


Ser Ser Val Gln Leu Tyr Arg Gln Ser Ser Lys Met Cys Gly Thr Val 
        195                 200                 205


Phe Thr Gly Ala Ser Arg Phe Arg Cys Arg Gln Cys Ser Ala Ala Tyr 
    210                 215                 220


Asp Thr Leu Val Glu Leu Thr Val His Met Asn Glu Thr Gly His Tyr 
225                 230                 235                 240


Gln Asp Asp Asn Arg Lys Lys Asp Lys Leu Arg Pro Thr Ser Tyr Ser 
                245                 250                 255


Lys Pro Arg Lys Arg Ala Phe Gln Asp Met Asp Lys Glu Asp Ala Gln 
            260                 265                 270


Lys Val Leu Lys Cys Met Phe Cys Gly Asp Ser Phe Asp Ser Leu Gln 
        275                 280                 285


Asp Leu Ser Val His Met Ile Lys Thr Lys His Tyr Gln Lys Val Pro 
    290                 295                 300


Leu Lys Glu Pro Val Pro Thr Ile Ser Ser Lys Met Val Thr Pro Ala 
305                 310                 315                 320


Lys Lys Arg Val Phe Asp Val Asn Arg Pro Cys Ser Pro Asp Ser Thr 
                325                 330                 335


Thr Gly Ser Phe Ala Asp Ser Phe Ser Ser Gln Lys Asn Ala Asn Leu 
            340                 345                 350


Gln Leu Ser Ser Asn Asn Arg Tyr Gly Tyr Gln Asn Gly Ala Ser Tyr 
        355                 360                 365


Thr Trp Gln Phe Glu Ala Cys Lys Ser Gln Ile Leu Lys Cys Met Glu 
    370                 375                 380


Cys Gly Ser Ser His Asp Thr Leu Gln Gln Leu Thr Thr His Met Met 
385                 390                 395                 400


Val Thr Gly His Phe Leu Lys Val Thr Ser Ser Ala Ser Lys Lys Gly 
                405                 410                 415


Lys Gln Leu Val Leu Asp Pro Leu Ala Val Glu Lys Met Gln Ser Leu 
            420                 425                 430


Ser Glu Ala Pro Asn Ser Asp Ser Leu Ala Pro Lys Pro Ser Ser Asn 
        435                 440                 445


Ser Ala Ser Asp Cys Thr Ala Ser Thr Thr Glu Leu Lys Lys Glu Ser 
    450                 455                 460


Lys Lys Glu Arg Pro Glu Glu Thr Ser Lys Asp Glu Lys Val Val Lys 
465                 470                 475                 480


Ser Glu Asp Tyr Glu Asp Pro Leu Gln Lys Pro Leu Asp Pro Thr Ile 
                485                 490                 495


Lys Tyr Gln Tyr Leu Arg Glu Glu Asp Leu Glu Asp Gly Ser Lys Gly 
            500                 505                 510


Gly Gly Asp Ile Leu Lys Ser Leu Glu Asn Thr Val Thr Thr Ala Ile 
        515                 520                 525


Asn Lys Ala Gln Asn Gly Ala Pro Ser Trp Ser Ala Tyr Pro Ser Ile 
    530                 535                 540


His Ala Ala Tyr Gln Leu Ser Glu Gly Thr Lys Pro Pro Leu Pro Met 
545                 550                 555                 560


Gly Ser Gln Val Leu Gln Ile Arg Pro Asn Leu Thr Asn Lys Leu Arg 
                565                 570                 575


Pro Ile Ala Pro Lys Trp Lys Val Met Pro Leu Val Ser Met Pro Thr 
            580                 585                 590


His Leu Ala Pro Tyr Thr Gln Val Lys Lys Glu Ser Glu Asp Lys Asp 
        595                 600                 605


Glu Ala Val Lys Glu Cys Gly Lys Glu Ser Pro His Glu Glu Ala Ser 
    610                 615                 620


Ser Phe Ser His Ser Glu Gly Asp Ser Phe Arg Lys Ser Glu Thr Pro 
625                 630                 635                 640


Pro Glu Ala Lys Lys Thr Glu Leu Gly Pro Leu Lys Glu Glu Glu Lys 
                645                 650                 655


Leu Met Lys Glu Gly Ser Glu Lys Glu Lys Pro Gln Pro Leu Glu Pro 
            660                 665                 670


Thr Ser Ala Leu Ser Asn Gly Cys Ala Leu Ala Asn His Ala Pro Ala 
        675                 680                 685


Leu Pro Cys Ile Asn Pro Leu Ser Ala Leu Gln Ser Val Leu Asn Asn 
    690                 695                 700


His Leu Gly Lys Ala Thr Glu Pro Leu Arg Ser Pro Ser Cys Ser Ser 
705                 710                 715                 720


Pro Ser Ser Ser Thr Ile Ser Met Phe His Lys Ser Asn Leu Asn Val 
                725                 730                 735


Met Asp Lys Pro Val Leu Ser Pro Ala Ser Thr Arg Ser Ala Ser Val 
            740                 745                 750


Ser Arg Arg Tyr Leu Phe Glu Asn Ser Asp Gln Pro Ile Asp Leu Thr 
        755                 760                 765


Lys Ser Lys Ser Lys Lys Ala Glu Ser Ser Gln Ala Gln Ser Cys Met 
    770                 775                 780


Ser Pro Pro Gln Lys His Ala Leu Ser Asp Ile Ala Asp Met Val Lys 
785                 790                 795                 800


Val Leu Pro Lys Ala Thr Thr Pro Lys Pro Ala Ser Ser Ser Arg Val 
                805                 810                 815


Pro Pro Met Lys Leu Glu Met Asp Val Arg Arg Phe Glu Asp Val Ser 
            820                 825                 830


Ser Glu Val Ser Thr Leu His Lys Arg Lys Gly Arg Gln Ser Asn Trp 
        835                 840                 845


Asn Pro Gln His Leu Leu Ile Leu Gln Ala Gln Phe Ala Ser Ser Leu 
    850                 855                 860


Phe Gln Thr Ser Glu Gly Lys Tyr Leu Leu Ser Asp Leu Gly Pro Gln 
865                 870                 875                 880


Glu Arg Met Gln Ile Ser Lys Phe Thr Gly Leu Ser Met Thr Thr Ile 
                885                 890                 895


Ser His Trp Leu Ala Asn Val Lys Tyr Gln Leu Arg Lys Thr Gly Gly 
            900                 905                 910


Thr Lys Phe Leu Lys Asn Met Asp Lys Gly His Pro Ile Phe Tyr Cys 
        915                 920                 925


Ser Asp Cys Ala Ser Gln Phe Arg Thr Pro Ser Thr Tyr Ile Ser His 
    930                 935                 940


Leu Glu Ser His Leu Gly Phe Gln Met Lys Asp Met Thr Arg Leu Ser 
945                 950                 955                 960


Val Asp Gln Gln Ser Lys Val Glu Gln Glu Ile Ser Arg Val Ser Ser 
                965                 970                 975


Ala Gln Arg Ser Pro Glu Thr Ile Ala Ala Glu Glu Asp Thr Asp Ser 
            980                 985                 990


Lys Phe Lys Cys Lys Leu Cys Cys Arg Thr Phe Val Ser Lys His Ala 
        995                 1000                1005


Val Lys Leu His Leu Ser Lys Thr His Ser Lys Ser Pro Glu His His 
    1010                1015                1020


Ser Gln Phe Val Thr Asp Val Asp Glu Glu 
1025                1030


<210>  1286
<211>  1625
<212>  DNA
<213>  Homo sapiens

<400>  1286
cgtgagcttc tggaacagcc ggaaaccttg tcaactgtcc aggtagtttg tccacctgaa     60

gtctcaccta tgacttctct ggatcctttg gcatcctagc actgaaatct gcaaagctgc    120

ttatgtactt tctgtaaggt gaaaattacg gatgcagcac ctgtgattaa gtcatgatgg    180

ctggaagtaa atcttggtga atatttctaa atgttttcca catttcccat acagaggttt    240

gataatttgt tcacctagtt tccattttat aattgaggtt ggcagtggag accaagactc    300

gatgtggtgt gggtcaattt ggaagaatta cttcgaagaa aatgagaaag aaacactcaa    360

atgaaatccc ttttgaggaa ggagatactc ttttccttaa aaaaaaaaaa atcaacattt    420

gtatcaataa aggttgagat cagaaaatgt ttcccgttca atgagaaaga tttggactgt    480

gatgaagata aactaaaaag aaaagagttt gaccaactgg caagggtttg acccctttcc    540

cctttaaaaa aatcacacta aaactacagc ttatgtttcg catgagtgga tgctctgaat    600

tgcaatgcaa agtgcttatg aaaacttaag atcttacatt actacttcaa agagtacatg    660

tgataggaat tcctatagaa gaaaatgaaa aaggatatag cttgaaaatc caaatttata    720

gcaaattctg catctatcat ttggcgatgc tatgactgga tgctatcact atttggaagt    780

atcaaaaata ttacaaagga aaattaagct tcattttact ctatcttctt ataaagtgag    840

gcccacatcc tggtgatgac tatttcctta atgagactat gggattttat caaactccat    900

aaaacatgat tgcatttcct tcactctgaa atcaccttat tttaatttcc acatgaaatt    960

gggatgcaat ttgtgtgtac atttaatatg cgagggttcc ttctccacct ctcactcact   1020

cctccccaaa aaagctttgg ccaaatctac agcatgtttt acaatggaca gagtcttagg   1080

attgaggcaa gtacaatcaa gaggagtcag gggctaagat aaacaaaaga acatgaaaac   1140

agtgatggtg atgcctcatg tgattagctc tatggtccct tcctcttctc agagtgacag   1200

gcagaaaaat cgacagttaa ttccagatcc atcaggggct gtgctgcctt tctacagaaa   1260

tgatgagttt agagagcaag ctgcagatga gtgtctgagc actcgcggga ggtgccgagt   1320

gtcatggcag aagttcgtgt ggcatcgctg tctgctgcgt ccaagagatg atagggtcct   1380

tccagaagag gaacagcagg gtagcgcaga aatggaagga agaccactct tcccagtttc   1440

tggccaatgg gatgagggaa gaagtgatgg gcatcagtta cagaactcat tcacaccttc   1500

aatggttttg gaagccacat gctccagatg gcagagctac cctggaaaga aggttgcatc   1560

tgagtcacca cgtggagatc aactttgtac atgtgaaaca taaatgttta ctgtgttggg   1620

ccact                                                               1625


<210>  1287
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  1287

Met Val Pro Ser Ser Ser Gln Ser Asp Arg Gln Lys Asn Arg Gln Leu 
1               5                   10                  15


Ile Pro Asp Pro Ser Gly Ala Val Leu Pro Phe Tyr Arg Asn Asp Glu 
            20                  25                  30


Phe Arg Glu Gln Ala Ala Asp Glu Cys Leu Ser Thr Arg Gly Arg Cys 
        35                  40                  45


Arg Val Ser Trp Gln Lys Phe Val Trp His Arg Cys Leu Leu Arg Pro 
    50                  55                  60


Arg Asp Asp Arg Val Leu Pro Glu Glu Glu Gln Gln Gly Ser Ala Glu 
65                  70                  75                  80


Met Glu Gly Arg Pro Leu Phe Pro Val Ser Gly Gln Trp Asp Glu Gly 
                85                  90                  95


Arg Ser Asp Gly His Gln Leu Gln Asn Ser Phe Thr Pro Ser Met Val 
            100                 105                 110


Leu Glu Ala Thr Cys Ser Arg Trp Gln Ser Tyr Pro Gly Lys Lys Val 
        115                 120                 125


Ala Ser Glu Ser Pro Arg Gly Asp Gln Leu Cys Thr Cys Glu Thr 
    130                 135                 140


<210>  1288
<211>  2438
<212>  DNA
<213>  Homo sapiens

<400>  1288
ctcgggccgc tgcgctcctg gccagctccc cccagcgcct gggaggcgac ccccagtgcg     60

cccgggttca aaggcccggc gaggcagttc cagcccctct ggggggcggg gaggcgacgg    120

gggtggtgca gaagccagaa aagcccgagc cacagccggc cagctccgcg cagggatggg    180

cagcgcgctc tgaaagttta tgaccgccgc agccaactcc tggccggagc tggagacgca    240

gcgagcgatc ggccggcctc gaacccccac agctggaggg cgaggccagc tgtacccggc    300

cccagtgccc tttcgcggcc acaagcggcc gtcctcctgg tccggtgctc cggcgcctga    360

tctaggttca tggagccggg gctgtggctc cttttcgggc tcacagtgac ctccgccgca    420

ggattcgtgc cttgctccca gtctggggat gctggcaggc gcggcgtgtc ccaggccccc    480

actgcagcca gatctgaggg ggactgtgaa gagactgtgg ctggccctgg cgaggagact    540

gtggctggcc ctggcgaggg gactgtggcc ccgacagcac tgcagggtcc aagccctgga    600

agccctgggc aggagcaggc ggccgagggg gcccctgagc accaccgatc caggcgctgc    660

acgtgcttca cctacaagga caaggagtgt gtctactatt gccacctgga catcatttgg    720

atcaacactc ccgaacagac ggtgccctat ggactgtcca actacagagg aagcttccgg    780

ggcaagaggt ctgcggggcc acttccaggg aatctgcagc tctcacatcg gccacacttg    840

cgctgcgctt gtgtggggag atatgacaag gcctgcctgc acttttgcac ccaaactctg    900

gacgtcagca gtaattcaag gacggcagaa aaaacagaca aagaagagga agggaaggtt    960

gaagtcaagg accaacaaag caagcaggct ttagacctcc accatccaaa gctcatgccc   1020

ggcagtggac tcgccctcgc tccatctacc tgcccccgct gcctctttca ggaaggagcc   1080

ccttaggagg acaggcctgc actccggttt catgcaggaa attggttttg gagagttttg   1140

gcaagttgga aagccactta ctggcttttg acatgacttc tcttggagaa taagtggact   1200

ccaagctaac tctttgcaaa tgtaaacaca tgtccatctt gtaataaatg caaaatgccc   1260

gtgcagcaga agcatgcgac tttcatatcc ttgcctagaa taggctgcat ggtgtatgtc   1320

agtgagggcc acgaggcgtc ggctttagac acagatcata gctctacagg agtttatgaa   1380

tttgaagctt atgggatttt ggcagagaaa ttttcagctg tgcttgatac ccaccaaaag   1440

aatgtatctc gaaagaatga aggaagaaga aaaaaggatc cttgatgttt gtgacaagaa   1500

aatgagaaag ttagtatctg caatacagag cttgttcctg ttcagtgact gaccctctgt   1560

attctgtata gacaccaggc cgatacacag tggagttccc aggccttgtt tgcaggaagc   1620

cgactgtaaa gacagcccca gctcaaggct attaggttga atatttgctt tcatgagtaa   1680

atgtggatct ttggggaatg gcttcaaaat aagtcacgaa cacaaattct ttgtaaatta   1740

tgtaaattcc tgtttatata aattggcaac aacttatacc gtctgacagt tcaaaatctc   1800

tttcagctgc gctcttccca ccgagccgag cttactgtga gtgtggagat gttatcccac   1860

catgtaaagt cgcctgcgca ggggagggct gcccatctcc ccaacccagt cacagagaga   1920

taggaaacgg catttgagtg ggtgtccagg gccccgtaga gagacattta agatggtgta   1980

tgacagagca ttggccttga ccaaatgtta aatcctctgt gtgtatttca taagttatta   2040

caggtataaa agtgatgacc tatcatgagg aaatgaaagt ggctgatttg ctggtaggat   2100

tttgtacagt ttagagaagc gattatttat tgtgaaactg ttctccactc caactccttt   2160

atgtggatct gttcaaagta gtcactgtat atacgtatag agaggtagat aggtaggtag   2220

attttaaatt gcattctgaa tacaaactca tactccttag agcttgaatt acatttttaa   2280

aatgcatatg tgctgtttgg caccgtggca agatggtatc agagagaaac ccatcaattg   2340

ctcaaatact cagaaagtac tgtcaaaagc ctaataaaaa acctaaagtt tgctctgaaa   2400

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                           2438


<210>  1289
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  1289

Met Glu Pro Gly Leu Trp Leu Leu Phe Gly Leu Thr Val Thr Ser Ala 
1               5                   10                  15


Ala Gly Phe Val Pro Cys Ser Gln Ser Gly Asp Ala Gly Arg Arg Gly 
            20                  25                  30


Val Ser Gln Ala Pro Thr Ala Ala Arg Ser Glu Gly Asp Cys Glu Glu 
        35                  40                  45


Thr Val Ala Gly Pro Gly Glu Glu Thr Val Ala Gly Pro Gly Glu Gly 
    50                  55                  60


Thr Val Ala Pro Thr Ala Leu Gln Gly Pro Ser Pro Gly Ser Pro Gly 
65                  70                  75                  80


Gln Glu Gln Ala Ala Glu Gly Ala Pro Glu His His Arg Ser Arg Arg 
                85                  90                  95


Cys Thr Cys Phe Thr Tyr Lys Asp Lys Glu Cys Val Tyr Tyr Cys His 
            100                 105                 110


Leu Asp Ile Ile Trp Ile Asn Thr Pro Glu Gln Thr Val Pro Tyr Gly 
        115                 120                 125


Leu Ser Asn Tyr Arg Gly Ser Phe Arg Gly Lys Arg Ser Ala Gly Pro 
    130                 135                 140


Leu Pro Gly Asn Leu Gln Leu Ser His Arg Pro His Leu Arg Cys Ala 
145                 150                 155                 160


Cys Val Gly Arg Tyr Asp Lys Ala Cys Leu His Phe Cys Thr Gln Thr 
                165                 170                 175


Leu Asp Val Ser Ser Asn Ser Arg Thr Ala Glu Lys Thr Asp Lys Glu 
            180                 185                 190


Glu Glu Gly Lys Val Glu Val Lys Asp Gln Gln Ser Lys Gln Ala Leu 
        195                 200                 205


Asp Leu His His Pro Lys Leu Met Pro Gly Ser Gly Leu Ala Leu Ala 
    210                 215                 220


Pro Ser Thr Cys Pro Arg Cys Leu Phe Gln Glu Gly Ala Pro 
225                 230                 235


<210>  1290
<211>  2694
<212>  DNA
<213>  Homo sapiens

<400>  1290
ctcgggccgc tgcgctcctg gccagctccc cccagcgcct gggaggcgac ccccagtgcg     60

cccgggttca aaggcccggc gaggcagttc cagcccctct ggggggcggg gaggcgacgg    120

gggtggtgca gaagccagaa aagcccgagc cacagccggc cagctccgcg cagggatggg    180

cagcgcgctc tgaaagttta tgaccgccgc agccaactcc tggccggagc tggagacgca    240

gcgagcgatc ggccggcctc gaacccccac agctggaggg cgaggccagc tgtacccggc    300

cccagtgccc tttcgcggcc acaagcggcc gtcctcctgg tccggtgctc cggcgcctga    360

tctaggttca tggagccggg gctgtggctc cttttcgggc tcacagtgac ctccgccgca    420

ggattcgtgc cttgctccca gtctggggat gctggcaggc gcggcgtgtc ccaggccccc    480

actgcagcca gatctgaggg ggactgtgaa gagactgtgg ctggccctgg cgaggagact    540

gtggctggcc ctggcgaggg gactgtggcc ccgacagcac tgcagggtcc aagccctgga    600

agccctgggc aggagcaggc ggccgagggg gcccctgagc accaccgatc caggcgctgc    660

acgtgcttca cctacaagga caaggagtgt gtctactatt gccacctgga catcatttgg    720

atcaacactc ccgaacagac ggtgccctat ggactgtcca actacagagg aagcttccgg    780

ggcaagaggt ctgcggggcc acttccaggg aatctgcagc tctcacatcg gccacacttg    840

cgctgcgctt gtgtggggag atatgacaag gcctgcctgc acttttgcac ccaaactctg    900

gacgtcagca gtaattcaag gacggcagaa aaaacagaca aagaagagga agggaaggtg    960

agaggtgcca acagaggcct gtgtcaaagg aggttgaagt caaggaccaa caaagcaagc   1020

aggctttaga cctccaccat ccaaagctca tgcccggcag tggactcgcc ctcgctccat   1080

ctacctgccc ccgctgcctc tttcaggaag gagcccctta ggaggacagg cctgcagcat   1140

cctggtctcg ggaggcttct gtcattgctc acacacagtt cagatttcca cctctttata   1200

gacaagaagt gaatttgcct ggggcagaac acccacccaa agagtcccca cttaacaata   1260

cccccccccc acggcaagaa tgcccaaatc cgaatgaccc cagttttcct aatgagtaaa   1320

atgatcccag atgtgcccca gagcatgacg cctgcagctc cggtttcatg caggaaattg   1380

gttttggaga gttttggcaa gttggaaagc cacttactgg cttttgacat gacttctctt   1440

ggagaataag tggactccaa gctaactctt tgcaaatgta aacacatgtc catcttgtaa   1500

taaatgcaaa atgcccgtgc agcagaagca tgcgactttc atatccttgc ctagaatagg   1560

ctgcatggtg tatgtcagtg agggccacga ggcgtcggct ttagacacag atcatagctc   1620

tacaggagtt tatgaatttg aagcttatgg gattttggca gagaaatttt cagctgtgct   1680

tgatacccac caaaagaatg tatctcgaaa gaatgaagga agaagaaaaa aggatccttg   1740

atgtttgtga caagaaaatg agaaagttag tatctgcaat acagagcttg ttcctgttca   1800

gtgactgacc ctctgtattc tgtatagaca ccaggccgat acacagtgga gttcccaggc   1860

cttgtttgca ggaagccgac tgtaaagaca gccccagctc aaggctatta ggttgaatat   1920

ttgctttcat gagtaaatgt ggatctttgg ggaatggctt caaaataagt cacgaacaca   1980

aattctttgt aaattatgta aattcctgtt tatataaatt ggcaacaact tataccgtct   2040

gacagttcaa aatctctttc agctgcgctc ttcccaccga gccgagctta ctgtgagtgt   2100

ggagatgtta tcccaccatg taaagtcgcc tgcgcagggg agggctgccc atctccccaa   2160

cccagtcaca gagagatagg aaacggcatt tgagtgggtg tccagggccc cgtagagaga   2220

catttaagat ggtgtatgac agagcattgg ccttgaccaa atgttaaatc ctctgtgtgt   2280

atttcataag ttattacagg tataaaagtg atgacctatc atgaggaaat gaaagtggct   2340

gatttgctgg taggattttg tacagtttag agaagcgatt atttattgtg aaactgttct   2400

ccactccaac tcctttatgt ggatctgttc aaagtagtca ctgtatatac gtatagagag   2460

gtagataggt aggtagattt taaattgcat tctgaataca aactcatact ccttagagct   2520

tgaattacat ttttaaaatg catatgtgct gtttggcacc gtggcaagat ggtatcagag   2580

agaaacccat caattgctca aatactcaga aagtactgtc aaaagcctaa taaaaaacct   2640

aaagtttgct ctgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa         2694


<210>  1291
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  1291

Met Glu Pro Gly Leu Trp Leu Leu Phe Gly Leu Thr Val Thr Ser Ala 
1               5                   10                  15


Ala Gly Phe Val Pro Cys Ser Gln Ser Gly Asp Ala Gly Arg Arg Gly 
            20                  25                  30


Val Ser Gln Ala Pro Thr Ala Ala Arg Ser Glu Gly Asp Cys Glu Glu 
        35                  40                  45


Thr Val Ala Gly Pro Gly Glu Glu Thr Val Ala Gly Pro Gly Glu Gly 
    50                  55                  60


Thr Val Ala Pro Thr Ala Leu Gln Gly Pro Ser Pro Gly Ser Pro Gly 
65                  70                  75                  80


Gln Glu Gln Ala Ala Glu Gly Ala Pro Glu His His Arg Ser Arg Arg 
                85                  90                  95


Cys Thr Cys Phe Thr Tyr Lys Asp Lys Glu Cys Val Tyr Tyr Cys His 
            100                 105                 110


Leu Asp Ile Ile Trp Ile Asn Thr Pro Glu Gln Thr Val Pro Tyr Gly 
        115                 120                 125


Leu Ser Asn Tyr Arg Gly Ser Phe Arg Gly Lys Arg Ser Ala Gly Pro 
    130                 135                 140


Leu Pro Gly Asn Leu Gln Leu Ser His Arg Pro His Leu Arg Cys Ala 
145                 150                 155                 160


Cys Val Gly Arg Tyr Asp Lys Ala Cys Leu His Phe Cys Thr Gln Thr 
                165                 170                 175


Leu Asp Val Ser Ser Asn Ser Arg Thr Ala Glu Lys Thr Asp Lys Glu 
            180                 185                 190


Glu Glu Gly Lys Val Arg Gly Ala Asn Arg Gly Leu Cys Gln Arg Arg 
        195                 200                 205


Leu Lys Ser Arg Thr Asn Lys Ala Ser Arg Leu 
    210                 215


<210>  1292
<211>  2617
<212>  DNA
<213>  Homo sapiens

<400>  1292
ctcgggccgc tgcgctcctg gccagctccc cccagcgcct gggaggcgac ccccagtgcg     60

cccgggttca aaggcccggc gaggcagttc cagcccctct ggggggcggg gaggcgacgg    120

gggtggtgca gaagccagaa aagcccgagc cacagccggc cagctccgcg cagggatggg    180

cagcgcgctc tgaaagttta tgaccgccgc agccaactcc tggccggagc tggagacgca    240

gcgagcgatc ggccggcctc gaacccccac agctggaggg cgaggccagc tgtacccggc    300

cccagtgccc tttcgcggcc acaagcggcc gtcctcctgg tccggtgctc cggcgcctga    360

tctaggttca tggagccggg gctgtggctc cttttcgggc tcacagtgac ctccgccgca    420

ggattcgtgc cttgctccca gtctggggat gctggcaggc gcggcgtgtc ccaggccccc    480

actgcagcca gatctgaggg ggactgtgaa gagactgtgg ctggccctgg cgaggagact    540

gtggctggcc ctggcgaggg gactgtggcc ccgacagcac tgcagggtcc aagccctgga    600

agccctgggc aggagcaggc ggccgagggg gcccctgagc accaccgatc caggcgctgc    660

acgtgcttca cctacaagga caaggagtgt gtctactatt gccacctgga catcatttgg    720

atcaacactc ccgaacagac ggtgccctat ggactgtcca actacagagg aagcttccgg    780

ggcaagaggt ctgcggggcc acttccaggg aatctgcagc tctcacatcg gccacacttg    840

cgctgcgctt gtgtggggag atatgacaag gcctgcctgc acttttgcac ccaaactctg    900

gacgtcagca gacaggttga agtcaaggac caacaaagca agcaggcttt agacctccac    960

catccaaagc tcatgcccgg cagtggactc gccctcgctc catctacctg cccccgctgc   1020

ctctttcagg aaggagcccc ttaggaggac aggcctgcag catcctggtc tcgggaggct   1080

tctgtcattg ctcacacaca gttcagattt ccacctcttt atagacaaga agtgaatttg   1140

cctggggcag aacacccacc caaagagtcc ccacttaaca ataccccccc cccacggcaa   1200

gaatgcccaa atccgaatga ccccagtttt cctaatgagt aaaatgatcc cagatgtgcc   1260

ccagagcatg acgcctgcag ctccggtttc atgcaggaaa ttggttttgg agagttttgg   1320

caagttggaa agccacttac tggcttttga catgacttct cttggagaat aagtggactc   1380

caagctaact ctttgcaaat gtaaacacat gtccatcttg taataaatgc aaaatgcccg   1440

tgcagcagaa gcatgcgact ttcatatcct tgcctagaat aggctgcatg gtgtatgtca   1500

gtgagggcca cgaggcgtcg gctttagaca cagatcatag ctctacagga gtttatgaat   1560

ttgaagctta tgggattttg gcagagaaat tttcagctgt gcttgatacc caccaaaaga   1620

atgtatctcg aaagaatgaa ggaagaagaa aaaaggatcc ttgatgtttg tgacaagaaa   1680

atgagaaagt tagtatctgc aatacagagc ttgttcctgt tcagtgactg accctctgta   1740

ttctgtatag acaccaggcc gatacacagt ggagttccca ggccttgttt gcaggaagcc   1800

gactgtaaag acagccccag ctcaaggcta ttaggttgaa tatttgcttt catgagtaaa   1860

tgtggatctt tggggaatgg cttcaaaata agtcacgaac acaaattctt tgtaaattat   1920

gtaaattcct gtttatataa attggcaaca acttataccg tctgacagtt caaaatctct   1980

ttcagctgcg ctcttcccac cgagccgagc ttactgtgag tgtggagatg ttatcccacc   2040

atgtaaagtc gcctgcgcag gggagggctg cccatctccc caacccagtc acagagagat   2100

aggaaacggc atttgagtgg gtgtccaggg ccccgtagag agacatttaa gatggtgtat   2160

gacagagcat tggccttgac caaatgttaa atcctctgtg tgtatttcat aagttattac   2220

aggtataaaa gtgatgacct atcatgagga aatgaaagtg gctgatttgc tggtaggatt   2280

ttgtacagtt tagagaagcg attatttatt gtgaaactgt tctccactcc aactccttta   2340

tgtggatctg ttcaaagtag tcactgtata tacgtataga gaggtagata ggtaggtaga   2400

ttttaaattg cattctgaat acaaactcat actccttaga gcttgaatta catttttaaa   2460

atgcatatgt gctgtttggc accgtggcaa gatggtatca gagagaaacc catcaattgc   2520

tcaaatactc agaaagtact gtcaaaagcc taataaaaaa cctaaagttt gctctgaaaa   2580

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                            2617


<210>  1293
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  1293

Met Glu Pro Gly Leu Trp Leu Leu Phe Gly Leu Thr Val Thr Ser Ala 
1               5                   10                  15


Ala Gly Phe Val Pro Cys Ser Gln Ser Gly Asp Ala Gly Arg Arg Gly 
            20                  25                  30


Val Ser Gln Ala Pro Thr Ala Ala Arg Ser Glu Gly Asp Cys Glu Glu 
        35                  40                  45


Thr Val Ala Gly Pro Gly Glu Glu Thr Val Ala Gly Pro Gly Glu Gly 
    50                  55                  60


Thr Val Ala Pro Thr Ala Leu Gln Gly Pro Ser Pro Gly Ser Pro Gly 
65                  70                  75                  80


Gln Glu Gln Ala Ala Glu Gly Ala Pro Glu His His Arg Ser Arg Arg 
                85                  90                  95


Cys Thr Cys Phe Thr Tyr Lys Asp Lys Glu Cys Val Tyr Tyr Cys His 
            100                 105                 110


Leu Asp Ile Ile Trp Ile Asn Thr Pro Glu Gln Thr Val Pro Tyr Gly 
        115                 120                 125


Leu Ser Asn Tyr Arg Gly Ser Phe Arg Gly Lys Arg Ser Ala Gly Pro 
    130                 135                 140


Leu Pro Gly Asn Leu Gln Leu Ser His Arg Pro His Leu Arg Cys Ala 
145                 150                 155                 160


Cys Val Gly Arg Tyr Asp Lys Ala Cys Leu His Phe Cys Thr Gln Thr 
                165                 170                 175


Leu Asp Val Ser Arg Gln Val Glu Val Lys Asp Gln Gln Ser Lys Gln 
            180                 185                 190


Ala Leu Asp Leu His His Pro Lys Leu Met Pro Gly Ser Gly Leu Ala 
        195                 200                 205


Leu Ala Pro Ser Thr Cys Pro Arg Cys Leu Phe Gln Glu Gly Ala Pro 
    210                 215                 220


<210>  1294
<211>  2659
<212>  DNA
<213>  Homo sapiens

<400>  1294
ctcgggccgc tgcgctcctg gccagctccc cccagcgcct gggaggcgac ccccagtgcg     60

cccgggttca aaggcccggc gaggcagttc cagcccctct ggggggcggg gaggcgacgg    120

gggtggtgca gaagccagaa aagcccgagc cacagccggc cagctccgcg cagggatggg    180

cagcgcgctc tgaaagttta tgaccgccgc agccaactcc tggccggagc tggagacgca    240

gcgagcgatc ggccggcctc gaacccccac agctggaggg cgaggccagc tgtacccggc    300

cccagtgccc tttcgcggcc acaagcggcc gtcctcctgg tccggtgctc cggcgcctga    360

tctaggttca tggagccggg gctgtggctc cttttcgggc tcacagtgac ctccgccgca    420

ggattcgtgc cttgctccca gtctggggat gctggcaggc gcggcgtgtc ccaggccccc    480

actgcagcca gatctgaggg ggactgtgaa gagactgtgg ctggccctgg cgaggagact    540

gtggctggcc ctggcgaggg gactgtggcc ccgacagcac tgcagggtcc aagccctgga    600

agccctgggc aggagcaggc ggccgagggg gcccctgagc accaccgatc caggcgctgc    660

acgtgcttca cctacaagga caaggagtgt gtctactatt gccacctgga catcatttgg    720

atcaacactc ccgaacagac ggtgccctat ggactgtcca actacagagg aagcttccgg    780

ggcaagaggt ctgcggggcc acttccaggg aatctgcagc tctcacatcg gccacacttg    840

cgctgcgctt gtgtggggag atatgacaag gcctgcctgc acttttgcac ccaaactctg    900

gacgtcagca gtaattcaag gacggcagaa aaaacagaca aagaagagga agggaaggtt    960

gaagtcaagg accaacaaag caagcaggct ttagacctcc accatccaaa gctcatgccc   1020

ggcagtggac tcgccctcgc tccatctacc tgcccccgct gcctctttca ggaaggagcc   1080

ccttaggagg acaggcctgc agcatcctgg tctcgggagg cttctgtcat tgctcacaca   1140

cagttcagat ttccacctct ttatagacaa gaagtgaatt tgcctggggc agaacaccca   1200

cccaaagagt ccccacttaa caataccccc cccccacggc aagaatgccc aaatccgaat   1260

gaccccagtt ttcctaatga gtaaaatgat cccagatgtg ccccagagca tgacgcctgc   1320

agctccggtt tcatgcagga aattggtttt ggagagtttt ggcaagttgg aaagccactt   1380

actggctttt gacatgactt ctcttggaga ataagtggac tccaagctaa ctctttgcaa   1440

atgtaaacac atgtccatct tgtaataaat gcaaaatgcc cgtgcagcag aagcatgcga   1500

ctttcatatc cttgcctaga ataggctgca tggtgtatgt cagtgagggc cacgaggcgt   1560

cggctttaga cacagatcat agctctacag gagtttatga atttgaagct tatgggattt   1620

tggcagagaa attttcagct gtgcttgata cccaccaaaa gaatgtatct cgaaagaatg   1680

aaggaagaag aaaaaaggat ccttgatgtt tgtgacaaga aaatgagaaa gttagtatct   1740

gcaatacaga gcttgttcct gttcagtgac tgaccctctg tattctgtat agacaccagg   1800

ccgatacaca gtggagttcc caggccttgt ttgcaggaag ccgactgtaa agacagcccc   1860

agctcaaggc tattaggttg aatatttgct ttcatgagta aatgtggatc tttggggaat   1920

ggcttcaaaa taagtcacga acacaaattc tttgtaaatt atgtaaattc ctgtttatat   1980

aaattggcaa caacttatac cgtctgacag ttcaaaatct ctttcagctg cgctcttccc   2040

accgagccga gcttactgtg agtgtggaga tgttatccca ccatgtaaag tcgcctgcgc   2100

aggggagggc tgcccatctc cccaacccag tcacagagag ataggaaacg gcatttgagt   2160

gggtgtccag ggccccgtag agagacattt aagatggtgt atgacagagc attggccttg   2220

accaaatgtt aaatcctctg tgtgtatttc ataagttatt acaggtataa aagtgatgac   2280

ctatcatgag gaaatgaaag tggctgattt gctggtagga ttttgtacag tttagagaag   2340

cgattattta ttgtgaaact gttctccact ccaactcctt tatgtggatc tgttcaaagt   2400

agtcactgta tatacgtata gagaggtaga taggtaggta gattttaaat tgcattctga   2460

atacaaactc atactcctta gagcttgaat tacattttta aaatgcatat gtgctgtttg   2520

gcaccgtggc aagatggtat cagagagaaa cccatcaatt gctcaaatac tcagaaagta   2580

ctgtcaaaag cctaataaaa aacctaaagt ttgctctgaa aaaaaaaaaa aaaaaaaaaa   2640

aaaaaaaaaa aaaaaaaaa                                                2659


<210>  1295
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  1295

Met Glu Pro Gly Leu Trp Leu Leu Phe Gly Leu Thr Val Thr Ser Ala 
1               5                   10                  15


Ala Gly Phe Val Pro Cys Ser Gln Ser Gly Asp Ala Gly Arg Arg Gly 
            20                  25                  30


Val Ser Gln Ala Pro Thr Ala Ala Arg Ser Glu Gly Asp Cys Glu Glu 
        35                  40                  45


Thr Val Ala Gly Pro Gly Glu Glu Thr Val Ala Gly Pro Gly Glu Gly 
    50                  55                  60


Thr Val Ala Pro Thr Ala Leu Gln Gly Pro Ser Pro Gly Ser Pro Gly 
65                  70                  75                  80


Gln Glu Gln Ala Ala Glu Gly Ala Pro Glu His His Arg Ser Arg Arg 
                85                  90                  95


Cys Thr Cys Phe Thr Tyr Lys Asp Lys Glu Cys Val Tyr Tyr Cys His 
            100                 105                 110


Leu Asp Ile Ile Trp Ile Asn Thr Pro Glu Gln Thr Val Pro Tyr Gly 
        115                 120                 125


Leu Ser Asn Tyr Arg Gly Ser Phe Arg Gly Lys Arg Ser Ala Gly Pro 
    130                 135                 140


Leu Pro Gly Asn Leu Gln Leu Ser His Arg Pro His Leu Arg Cys Ala 
145                 150                 155                 160


Cys Val Gly Arg Tyr Asp Lys Ala Cys Leu His Phe Cys Thr Gln Thr 
                165                 170                 175


Leu Asp Val Ser Ser Asn Ser Arg Thr Ala Glu Lys Thr Asp Lys Glu 
            180                 185                 190


Glu Glu Gly Lys Val Glu Val Lys Asp Gln Gln Ser Lys Gln Ala Leu 
        195                 200                 205


Asp Leu His His Pro Lys Leu Met Pro Gly Ser Gly Leu Ala Leu Ala 
    210                 215                 220


Pro Ser Thr Cys Pro Arg Cys Leu Phe Gln Glu Gly Ala Pro 
225                 230                 235


<210>  1296
<211>  960
<212>  DNA
<213>  Homo sapiens

<400>  1296
atgaggtcag gaaatgattg cgggagaaga gcattcgtgt acacagagga cacgcaggcc     60

tccacgaccc gcgtgctgaa ttcggagacg gcagtcccct ccaaaggcct ggtgtccctg    120

cagctgccca ggctggtggg gaacggcaga atcatggaat ttcagaggat agaatgtggg    180

agggagcgag ggaagaaggc gggcaaggcg ctggcatgga gcagcatgga gctgattgat    240

gagacggtgg ggagacattt tacttgtgca ttgaaaagaa aaaccacgag gttacctggt    300

ggacccgttt gcggccacag tgccgccgtg gggattggag gccagaaggg aggcgcgtcg    360

gatggggaca caggcgccct tgccaccttg gcagtgtggg aaggcaggga gatggcaaag    420

gagaagggcc tggggcggtg tccggctctg cgagctgaag ccaaggctga ctccaagatg    480

ctctgtgcat ctcaaaaccc agccctcaga gccatgagct gtaccagcac ctccatatct    540

gttcccgtcg aaggggaggg tatcaccatc gcccgagtca cccacatcac aagcccaggc    600

cccatctcgg acccctccac catgttctgc cagtgtggtg tccactgctc ttcctttgca    660

ccccactgcc tcatctcaga cctggatgat ggccacagcc ttttagttcc agatgccagg    720

gtgtgggccg agggggtcac actggtcacg ggcaagtcca tgtgcagctt cttcagcgag    780

atctcacact ccatcacact ggaggagctg ccatgcaggg accacatcct caagctctgc    840

caggacatct tcctggcgtg cgagacccat gagctggagc tggaggagga gctgtctgcc    900

aagctcatct tcctctatcg ctcactggag accatgatca agtggactcg tgaggagtag    960


<210>  1297
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  1297

Met Arg Ser Gly Asn Asp Cys Gly Arg Arg Ala Phe Val Tyr Thr Glu 
1               5                   10                  15


Asp Thr Gln Ala Ser Thr Thr Arg Val Leu Asn Ser Glu Thr Ala Val 
            20                  25                  30


Pro Ser Lys Gly Leu Val Ser Leu Gln Leu Pro Arg Leu Val Gly Asn 
        35                  40                  45


Gly Arg Ile Met Glu Phe Gln Arg Ile Glu Cys Gly Arg Glu Arg Gly 
    50                  55                  60


Lys Lys Ala Gly Lys Ala Leu Ala Trp Ser Ser Met Glu Leu Ile Asp 
65                  70                  75                  80


Glu Thr Val Gly Arg His Phe Thr Cys Ala Leu Lys Arg Lys Thr Thr 
                85                  90                  95


Arg Leu Pro Gly Gly Pro Val Cys Gly His Ser Ala Ala Val Gly Ile 
            100                 105                 110


Gly Gly Gln Lys Gly Gly Ala Ser Asp Gly Asp Thr Gly Ala Leu Ala 
        115                 120                 125


Thr Leu Ala Val Trp Glu Gly Arg Glu Met Ala Lys Glu Lys Gly Leu 
    130                 135                 140


Gly Arg Cys Pro Ala Leu Arg Ala Glu Ala Lys Ala Asp Ser Lys Met 
145                 150                 155                 160


Leu Cys Ala Ser Gln Asn Pro Ala Leu Arg Ala Met Ser Cys Thr Ser 
                165                 170                 175


Thr Ser Ile Ser Val Pro Val Glu Gly Glu Gly Ile Thr Ile Ala Arg 
            180                 185                 190


Val Thr His Ile Thr Ser Pro Gly Pro Ile Ser Asp Pro Ser Thr Met 
        195                 200                 205


Phe Cys Gln Cys Gly Val His Cys Ser Ser Phe Ala Pro His Cys Leu 
    210                 215                 220


Ile Ser Asp Leu Asp Asp Gly His Ser Leu Leu Val Pro Asp Ala Arg 
225                 230                 235                 240


Val Trp Ala Glu Gly Val Thr Leu Val Thr Gly Lys Ser Met Cys Ser 
                245                 250                 255


Phe Phe Ser Glu Ile Ser His Ser Ile Thr Leu Glu Glu Leu Pro Cys 
            260                 265                 270


Arg Asp His Ile Leu Lys Leu Cys Gln Asp Ile Phe Leu Ala Cys Glu 
        275                 280                 285


Thr His Glu Leu Glu Leu Glu Glu Glu Leu Ser Ala Lys Leu Ile Phe 
    290                 295                 300


Leu Tyr Arg Ser Leu Glu Thr Met Ile Lys Trp Thr Arg Glu Glu 
305                 310                 315


<210>  1298
<211>  3063
<212>  DNA
<213>  Homo sapiens

<400>  1298
cgccggcggg gaagatgacc gcgggcgccg gcgtgctcct tctgctgctc tcgctctccg     60

gcgcgctccg ggcccataat gaggatctta caactagaga gacctgcaag gctgggttct    120

ctgaagatga ttacacggca ttaatctccc aaaatattct agaaggggaa aagctacttc    180

aagtcaagtt cagcagctgt gtggggacca aggggacaca atatgagacc aacagcatgg    240

acttcaaagt tggggcagat gggacagtct tcgccacccg ggagctgcag gtcccctccg    300

agcaggtggc gttcacggtg actgcatggg acagccagac agcagagaaa tgggacgccg    360

tggtgcggtt gctggtggcc cagacctcgt ccccgcactc tggacacaag ccgcagaaag    420

gaaagaaggt cgtggctctg gacccctctc cgcctccgaa ggacaccctg ctgccgtggc    480

cccagcacca gaacgccaac gggctgaggc ggcgcaaacg ggactgggtc atcccgccca    540

tcaacgtgcc cgagaactcg cgcgggccct tcccgcagca gctcgtgagg atccggtccg    600

acaaagacaa tgacatcccc atccggtaca gcatcacggg agtgggcgcc gaccagcccc    660

ccatggaggt cttcagcatt gactccatgt ccggccggat gtacgtcaca aggcccatgg    720

accgggagga gcacgcctct taccacctcc gagcccacgc tgtggacatg aatggcaaca    780

aggtggagaa ccccatcgac ctgtacatct acgtcatcga catgaatgac aaccgccctg    840

agttcatcaa ccaggtctac aacggctccg tggacgaggg ctccaagcca ggcacctacg    900

tgatgaccgt cacggccaac gatgctgacg acagcaccac ggccaacggg atggtgcggt    960

accggatcgt gacccagacc ccacagagcc cgtcccagaa tatgttcacc atcaacagcg   1020

agactggaga tatcgtcaca gtggcggctg gcctggaccg agagaaagtt cagcagtaca   1080

cagtcatcgt tcaggccaca gatatggaag gaaatctcaa ctatggcctc tcaaacacag   1140

ccacagccat catcacggtg acagatgtga atgacaaccc gccagaattt accgccagca   1200

cgtttgcagg ggaggtcccc gaaaaccgcg tggagaccgt ggtcgcaaac ctcacggtga   1260

tggaccgaga tcagccccac tctccaaact ggaatgccgt ttaccgcatc atcagtgggg   1320

atccatccgg gcacttcagc gtccgcacag accccgtaac caacgagggc atggtcaccg   1380

tggtgaaggc agtcgactac gagctcaaca gagctttcat gctgacagtg atggtgtcca   1440

accaggcgcc cctggccagc ggaatccaga tgtccttcca gtccacggca ggggtgacca   1500

tctccatcat ggacatcaac gaggctccct acttcccctc aaaccacaag ctgatccgcc   1560

tggaggaggg cgtgcccccc ggcaccgtgc tgaccacgtt ttcagctgtg gaccctgacc   1620

ggttcatgca gcaggctgtg agatactcaa agctgtcaga cccagcgagc tggctgcaca   1680

tcaatgccac caacggccag atcaccacgg cggcagtgct ggaccgtgag tccctctaca   1740

ccaaaaacaa cgtctacgag gccaccttcc tggcagctga caatgggata cccccggcca   1800

gcggcaccgg gaccctccag atctatctca ttgacatcaa cgacaacgcc cctgagctgc   1860

tgcccaagga ggcgcagatc tgcgagaagc ccaacctgaa cgccatcaac atcacggcgg   1920

ccgacgctga cgtcgacccc aacatcggcc cctacgtctt cgagctgccc tttgtcccgg   1980

cggccgtgcg gaagaactgg accatcaccc gcctgaacgg tgactatgcc caactcagct   2040

tgcgcatcct gtacctggag gccgggatgt atgacgtccc catcatcgtc acagactctg   2100

gaaaccctcc cctgtccaac acgtccatca tcaaagtcaa ggtgtgccca tgtgatgaca   2160

acggggactg caccaccatt ggcgcagtgg cagcggctgg tctgggcacc ggtgccatcg   2220

tggccatcct catctgcatc ctcatcctgc tgaccatggt cctgctgttt gtcatgtgga   2280

tgaagcggcg agagaaggag cgccacacga agcagctgct cattgacccc gaggacgacg   2340

tccgcgacaa catcctcaag tatgacgagg aaggcggtgg cgaggaggac caggactacg   2400

acctcagcca gctgcagcag ccggaagcca tggggcacgt gccaagcaaa gcccctggcg   2460

tgcgtcgcgt ggatgagcgg ccggtgggcg ctgagcccca gtacccgatc aggcccatgg   2520

tgccgcaccc aggcgacatc ggtgacttca tcaatgaggg actccgcgct gctgacaacg   2580

accccacggc acccccctat gactccctgc tggtcttcga ctacgagggg agcggctcca   2640

ccgcaggctc cgtcagctcc ctgaactcat ccagttccgg ggaccaagac tacgattacc   2700

tcaacgactg ggggcccaga ttcaagaagc tggcggacat gtatggaggt ggtgaagagg   2760

attgactgac ctcgcatctt cggaccgaag tgagagccgt gctcggacgc cggaggagca   2820

ggactgagca gaggcggccg gtcttcccga ctccctgcgg ctgtgtcctt agtgctgtta   2880

ggaggccccc caatccccac gttgagctgt ctagcatgag cacccacccc cacagcgccc   2940

tgcacccggc cgctgcccag caccgcgctg gctggcactg aaggacagca agaggcactc   3000

tgtcttcact tgaatttcct agaacagaag cactgttttt aaaaaaaaaa aaaaaaaaag   3060

aag                                                                 3063


<210>  1299
<211>  916
<212>  PRT
<213>  Homo sapiens

<400>  1299

Met Thr Ala Gly Ala Gly Val Leu Leu Leu Leu Leu Ser Leu Ser Gly 
1               5                   10                  15


Ala Leu Arg Ala His Asn Glu Asp Leu Thr Thr Arg Glu Thr Cys Lys 
            20                  25                  30


Ala Gly Phe Ser Glu Asp Asp Tyr Thr Ala Leu Ile Ser Gln Asn Ile 
        35                  40                  45


Leu Glu Gly Glu Lys Leu Leu Gln Val Lys Phe Ser Ser Cys Val Gly 
    50                  55                  60


Thr Lys Gly Thr Gln Tyr Glu Thr Asn Ser Met Asp Phe Lys Val Gly 
65                  70                  75                  80


Ala Asp Gly Thr Val Phe Ala Thr Arg Glu Leu Gln Val Pro Ser Glu 
                85                  90                  95


Gln Val Ala Phe Thr Val Thr Ala Trp Asp Ser Gln Thr Ala Glu Lys 
            100                 105                 110


Trp Asp Ala Val Val Arg Leu Leu Val Ala Gln Thr Ser Ser Pro His 
        115                 120                 125


Ser Gly His Lys Pro Gln Lys Gly Lys Lys Val Val Ala Leu Asp Pro 
    130                 135                 140


Ser Pro Pro Pro Lys Asp Thr Leu Leu Pro Trp Pro Gln His Gln Asn 
145                 150                 155                 160


Ala Asn Gly Leu Arg Arg Arg Lys Arg Asp Trp Val Ile Pro Pro Ile 
                165                 170                 175


Asn Val Pro Glu Asn Ser Arg Gly Pro Phe Pro Gln Gln Leu Val Arg 
            180                 185                 190


Ile Arg Ser Asp Lys Asp Asn Asp Ile Pro Ile Arg Tyr Ser Ile Thr 
        195                 200                 205


Gly Val Gly Ala Asp Gln Pro Pro Met Glu Val Phe Ser Ile Asp Ser 
    210                 215                 220


Met Ser Gly Arg Met Tyr Val Thr Arg Pro Met Asp Arg Glu Glu His 
225                 230                 235                 240


Ala Ser Tyr His Leu Arg Ala His Ala Val Asp Met Asn Gly Asn Lys 
                245                 250                 255


Val Glu Asn Pro Ile Asp Leu Tyr Ile Tyr Val Ile Asp Met Asn Asp 
            260                 265                 270


Asn Arg Pro Glu Phe Ile Asn Gln Val Tyr Asn Gly Ser Val Asp Glu 
        275                 280                 285


Gly Ser Lys Pro Gly Thr Tyr Val Met Thr Val Thr Ala Asn Asp Ala 
    290                 295                 300


Asp Asp Ser Thr Thr Ala Asn Gly Met Val Arg Tyr Arg Ile Val Thr 
305                 310                 315                 320


Gln Thr Pro Gln Ser Pro Ser Gln Asn Met Phe Thr Ile Asn Ser Glu 
                325                 330                 335


Thr Gly Asp Ile Val Thr Val Ala Ala Gly Leu Asp Arg Glu Lys Val 
            340                 345                 350


Gln Gln Tyr Thr Val Ile Val Gln Ala Thr Asp Met Glu Gly Asn Leu 
        355                 360                 365


Asn Tyr Gly Leu Ser Asn Thr Ala Thr Ala Ile Ile Thr Val Thr Asp 
    370                 375                 380


Val Asn Asp Asn Pro Pro Glu Phe Thr Ala Ser Thr Phe Ala Gly Glu 
385                 390                 395                 400


Val Pro Glu Asn Arg Val Glu Thr Val Val Ala Asn Leu Thr Val Met 
                405                 410                 415


Asp Arg Asp Gln Pro His Ser Pro Asn Trp Asn Ala Val Tyr Arg Ile 
            420                 425                 430


Ile Ser Gly Asp Pro Ser Gly His Phe Ser Val Arg Thr Asp Pro Val 
        435                 440                 445


Thr Asn Glu Gly Met Val Thr Val Val Lys Ala Val Asp Tyr Glu Leu 
    450                 455                 460


Asn Arg Ala Phe Met Leu Thr Val Met Val Ser Asn Gln Ala Pro Leu 
465                 470                 475                 480


Ala Ser Gly Ile Gln Met Ser Phe Gln Ser Thr Ala Gly Val Thr Ile 
                485                 490                 495


Ser Ile Met Asp Ile Asn Glu Ala Pro Tyr Phe Pro Ser Asn His Lys 
            500                 505                 510


Leu Ile Arg Leu Glu Glu Gly Val Pro Pro Gly Thr Val Leu Thr Thr 
        515                 520                 525


Phe Ser Ala Val Asp Pro Asp Arg Phe Met Gln Gln Ala Val Arg Tyr 
    530                 535                 540


Ser Lys Leu Ser Asp Pro Ala Ser Trp Leu His Ile Asn Ala Thr Asn 
545                 550                 555                 560


Gly Gln Ile Thr Thr Ala Ala Val Leu Asp Arg Glu Ser Leu Tyr Thr 
                565                 570                 575


Lys Asn Asn Val Tyr Glu Ala Thr Phe Leu Ala Ala Asp Asn Gly Ile 
            580                 585                 590


Pro Pro Ala Ser Gly Thr Gly Thr Leu Gln Ile Tyr Leu Ile Asp Ile 
        595                 600                 605


Asn Asp Asn Ala Pro Glu Leu Leu Pro Lys Glu Ala Gln Ile Cys Glu 
    610                 615                 620


Lys Pro Asn Leu Asn Ala Ile Asn Ile Thr Ala Ala Asp Ala Asp Val 
625                 630                 635                 640


Asp Pro Asn Ile Gly Pro Tyr Val Phe Glu Leu Pro Phe Val Pro Ala 
                645                 650                 655


Ala Val Arg Lys Asn Trp Thr Ile Thr Arg Leu Asn Gly Asp Tyr Ala 
            660                 665                 670


Gln Leu Ser Leu Arg Ile Leu Tyr Leu Glu Ala Gly Met Tyr Asp Val 
        675                 680                 685


Pro Ile Ile Val Thr Asp Ser Gly Asn Pro Pro Leu Ser Asn Thr Ser 
    690                 695                 700


Ile Ile Lys Val Lys Val Cys Pro Cys Asp Asp Asn Gly Asp Cys Thr 
705                 710                 715                 720


Thr Ile Gly Ala Val Ala Ala Ala Gly Leu Gly Thr Gly Ala Ile Val 
                725                 730                 735


Ala Ile Leu Ile Cys Ile Leu Ile Leu Leu Thr Met Val Leu Leu Phe 
            740                 745                 750


Val Met Trp Met Lys Arg Arg Glu Lys Glu Arg His Thr Lys Gln Leu 
        755                 760                 765


Leu Ile Asp Pro Glu Asp Asp Val Arg Asp Asn Ile Leu Lys Tyr Asp 
    770                 775                 780


Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp Tyr Asp Leu Ser Gln Leu 
785                 790                 795                 800


Gln Gln Pro Glu Ala Met Gly His Val Pro Ser Lys Ala Pro Gly Val 
                805                 810                 815


Arg Arg Val Asp Glu Arg Pro Val Gly Ala Glu Pro Gln Tyr Pro Ile 
            820                 825                 830


Arg Pro Met Val Pro His Pro Gly Asp Ile Gly Asp Phe Ile Asn Glu 
        835                 840                 845


Gly Leu Arg Ala Ala Asp Asn Asp Pro Thr Ala Pro Pro Tyr Asp Ser 
    850                 855                 860


Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly Ser Thr Ala Gly Ser Val 
865                 870                 875                 880


Ser Ser Leu Asn Ser Ser Ser Ser Gly Asp Gln Asp Tyr Asp Tyr Leu 
                885                 890                 895


Asn Asp Trp Gly Pro Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly 
            900                 905                 910


Gly Glu Glu Asp 
        915


<210>  1300
<211>  7292
<212>  DNA
<213>  Homo sapiens

<400>  1300
aacactgata tttgcattta atggggaaca aaagatgaag aaggaaaagg aatatattca     60

ctaaggattc tatctgctta ctgctacaga cctatgtgtt aaggaattct tctcctcctc    120

cttgcgtaga agttgatcag cactgtggtc agactgcatt tatcttgtca ttgccagaag    180

aaatcttgga cagaatgtaa cagtacgtct ctctctgatt gcgatggaag gtgataaact    240

gatactcctt tattaaagtt acatcgcact caccacagaa aaccattctt taaagtgaat    300

agaaaccaag cccttgtgaa cacttctatt gaacatgact catggagaag agcttggctc    360

tgatgtgcac caggattcta ttgttttaac ttacctagaa ggattactaa tgcatcaggc    420

agcaggggga tcaggtactg ccgttgacaa aaagtctgct gggcataatg aagaggatca    480

gaactttaac atttctggca gtgcatttcc cacctgtcaa agtaatggtc cagttctcaa    540

tacacataca tatcaggggt ctggcatgct gcacctcaaa aaagccagac tgttgcagtc    600

ttctgaggac tggaatgcag caaagcggaa gaggctgtct gattctatca tgaatttaaa    660

cgtaaagaag gaagctttgc tagctggcat ggttgacagt gtgcctaaag gcaaacagga    720

tagcacatta ctggcctctt tgcttcagtc attcagctct aggctgcaga ctgttgctct    780

gtcacaacaa atcaggcaga gcctcaagga gcaaggatat gccctcagtc atgattcttt    840

aaaagtggag aaggatttaa ggtgctatgg tgttgcatca agtcacttaa aaactttgtt    900

gaagaaaagt aaagttaaag atcaaaagcc tgatacgaat cttcctgatg tgactaaaaa    960

cctcatcaga gataggtttg cagagtctcc tcatcatgtt ggacaaagtg gaacaaaggt   1020

catgagtgaa ccgttgtcat gtgctgcaag attacaggct gttgcaagca tggtggaaaa   1080

aagggctagt cctgccacct cacctaaacc tagtgttgct tgtagccagt tagcattact   1140

tctgtcaagc gaagcccatt tgcagcagta ttctcgagaa cacgctttaa aaacgcaaaa   1200

tgcaaatcaa gcagcaagtg aaagacttgc tgctatggcc agattgcaag aaaatggcca   1260

gaaggatgtt ggcagttacc agctcccaaa aggaatgtca agccatctta atggtcaggc   1320

aagaacatca tcaagcaaac tgatggctag caaaagtagt gctacagtgt ttcaaaatcc   1380

aatgggtatc attccttctt cccctaaaaa tgcaggttat aagaactcac tggaaagaaa   1440

caatataaaa caagctgcta acaatagttt gcttttacat cttcttaaaa gccagactat   1500

acctaagcca atgaatggac acagtcacag tgagagagga agcatttttg aggaaagtag   1560

tacacctaca actattgatg aatattcaga taacaatcct agttttacag atgacagcag   1620

tggtgatgaa agttcttatt ccaactgtgt tcccatagac ttgtcttgca aacaccgaac   1680

tgaaaaatca gaatctgacc aacctgtttc cctggataac ttcactcaat ccttgctaaa   1740

cacttgggat ccaaaagtcc cagatgtaga tatcaaagaa gatcaagata cctcaaagaa   1800

ttctaagcta aactcacacc agaaagtaac acttcttcaa ttgctacttg gccataagaa   1860

tgaagaaaat gtagaaaaaa acaccagccc tcagggagta cacaatgatg tgagcaagtt   1920

caatacacaa aattatgcaa ggacttctgt gatagaaagc cccagtacaa atcggactac   1980

tccagtgagc actccacctt tacttacatc aagcaaagca gggtctccca tcaatctctc   2040

tcaacactct ctggtcatca aatggaattc cccaccatat gtctgcagta ctcagtctga   2100

aaagctaaca aatactgcat ctaaccactc aatggacctt acaaaaagca aagacccacc   2160

aggagagaaa ccagcccaaa atgaaggtgc acagaactct gcaacgttta gtgccagtaa   2220

gctgttacaa aatttagcac aatgtggaat gcagtcatcc atgtcagtgg aagagcagag   2280

acccagcaaa cagctgttaa ctggaaacac agataaaccg ataggtatga ttgatagatt   2340

aaatagccct ttgctctcaa ataaaacaaa tgcagttgaa gaaaataaag catttagtag   2400

tcaaccaaca ggtcctgaac cagggctttc tggttctgaa atagaaaatc tgcttgaaag   2460

acgtactgtc ctccagttgc tcctggggaa ccccaacaaa gggaagagtg aaaaaaaaga   2520

gaaaactccc ttaagagatg aaagtactca ggaacactca gagagagctt taagtgaaca   2580

aatactgatg gtgaaaataa aatctgagcc ttgtgatgac ttacaaattc ctaacacaaa   2640

tgtgcacttg agccatgatg ctaagagtgc cccattcttg ggtatggctc ctgctgtgca   2700

gagaagcgca cctgccttac cagtgtccga agactttaaa tcggagcctg tttcacctca   2760

ggatttttct ttctccaaga atggtctgct aagtcgattg ctaagacaaa atcaagatag   2820

ttacctggca gatgattcag acaggagtca cagaaataat gaaatggcac ttctagaatc   2880

aaagaatctt tgcatggtcc ctaagaaaag gaagctttat actgagccat tagaaaatcc   2940

atttaaaaag atgaaaaaca acattgttga tgctgcaaac aatcacagtg ccccagaagt   3000

actgtatggg tccttgctta accaggaaga gctgaaattt agcagaaatg atcttgaatt   3060

taaatatcct gctggtcatg gctcagccag cgaaagtgaa cacaggagtt gggccagaga   3120

gagcaaaagc tttaatgttc tgaaacagct gcttctctca gaaaactgtg tgcgagattt   3180

gtccccgcac agaagtaact ctgtggctga cagtaaaaag aaaggacaca aaaataatgt   3240

gaccaacagc aaacctgaat ttagcatttc ttctttaaat ggactgatgt acagttccac   3300

tcagcccagc agttgcatgg ataacaggac attttcatac ccaggtgtag taaaaactcc   3360

tgtgagtcct actttccctg agcacttggg ctgtgcaggg tctagaccag aatctgggct   3420

tttgaatggg tgttccatgc ccagtgagaa aggacccatt aagtgggtta tcactgatgc   3480

ggagaagaat gagtatgaaa aagactctcc aagattgacc aaaaccaacc caatactata   3540

ttacatgctt caaaaaggag gcaattctgt taccagtcga gaaacacaag acaaggacat   3600

ttggagggag gcttcatctg ctgaaagtgt ctcacaggtc acagccaaag aagagttact   3660

tcctactgca gaaacgaaag cttctttctt taatttaaga agcccttaca atagccatat   3720

gggaaataat gcttctcgcc cacacagcgc aaatggagaa gtttatggac ttctgggaag   3780

cgtgctaacg ataaagaaag aatcagaata aaatgtacct gccatccagt tttggatctt   3840

tttaaaacta atgagtatga acttgagatc tgtataaata agagcatgat ttgaaaaaaa   3900

gcatggtata attgaaactt ttttcatttt gaaaagtatt ggttactggt gatgttgaaa   3960

tatgcatact aatttttgct taacattaga tgtcatgagg aaactactga actagcaatt   4020

ggttgtttaa cacttctgta tgcatcagat aacaactgtg agtagcctat gaatgaaatt   4080

cttttataaa tattaggcat aaattaaaat gtaaaactcc attcatagtg gattaatgca   4140

ttttgctgcc tttattaggg tactttattt tgcttttcag aagtcagcct acataacaca   4200

tttttaaagt ctaaactgtt aaacaactct ttaaaggata attatccaat aaaaaaaaac   4260

ctagtgctga ttcacagctt attatccaat tcaaaaataa attagaaaaa tatatgctta   4320

catttttcac ttttgctaaa aagaaaaaaa aaaggtgttt atttttaact cttggaagag   4380

gttttgtggt tcccaatgtg tctgtcccac cctgatcctt ttcaatatat atttctttaa   4440

accttgtgct acttagtaaa aattgattac aattgaggga agtttgatag atcctttaaa   4500

aaaaaggcag atttccattt tttgtatttt aactacttta ctaaattaat actcctcctt   4560

ttacagaatt agaaaagtta acatttatct ttaggtggtt tcctgaaaag ttgaatattt   4620

aagaaattgt ttttaacaga agcaaaatgg cttttctttg gacagttttc accatctctt   4680

gtaaaagtta attctcacca ttcctgtggt acctgcgagt gttatgacca ggattcctta   4740

aacctgaact cagaccactt gcattagaac catctggagc acttgtttta aaatgcagat   4800

tcataggcag catctcagat ctacagaaca agaatctctg ctaagtggac ctggaatctt   4860

ccatctgcat cttaacatgc tctctaggtg tttcttgtgt ttgagaacca tgacttatga   4920

ctttcctcag aacatgagac tgtaaaacaa aaacaaaaaa ctatgtgatg cctctatttt   4980

ccccaataca gtcacacatc agctcaaaat ttgcaatatt gtagttcata tattaccgtt   5040

atgtctttgg aaatcgggtt cagaacactt tttatgacaa aaattgggtg gaggggataa   5100

ctttcatatc tggctcaaca tctcaggaaa atctgtgatt atttgtgtgt tctaatgagt   5160

aacatctact tagttagcct tagggatgga aaaacagggc cacttaccaa actcaggtga   5220

ttccaggatg gtttggaaac ttctcctgaa tgcatcctta acctttatta aaaccattgt   5280

cctaagaaca atgccaacaa agcttacaac atttagttta aacccaagaa gggcactaaa   5340

ctcagattga ctaaataaaa agtacaaagg gcacatatac gtgacagaat tgtacacaat   5400

cactccattg gatcttttac tttaaagtag tgatgaaaag tacatgttga tactgtctta   5460

gaagaaatta atatattagt gaagccacat ggggtttcag ttgcgaaaca ggtctgtttt   5520

tatgttcagt ttgtacaatc cacaattcat tcaccagata ttttgttctt aattgtgaac   5580

caggttagca aatgacctat caaaaattat tctataatca ctactagtta ggatattgat   5640

ttaaaattgt tctacttgaa gtggtttcta agatttttat attaaaaata ggtgtgattt   5700

cctaatatga tctaaaaccc taaatggtta tttttcctca gaatgatttg taaatagcta   5760

ctggaaatat tatacagtaa taggagtggg tattatgcaa catcatggag aagtgaaggc   5820

ataggcttat tctgacataa aattccactg gccagttgaa tatattctat tccatgtcca   5880

tactatgaca atcttattgt caacactata taaataagct tttaaacaag tcatttttct   5940

tgatcgttgt ggaaggtttg gagccttaga ggtatgtcag aaaaaatatg ttggtattct   6000

cccttgggta gggggaaatg acctttttac aagagagtga aatttaggtc agggaaaaga   6060

ccaagggcca gcattgctac ttttgtgtgt gtgtgtgtgg gttttgtttt gtttttttgg   6120

ttggctggtt gttttcgttg ttgttaacaa aggaatgaga atatgtaata cttaaataaa   6180

catgaccacg aagaatgctg ttctgattta ctagagaatg ttcccaattt gaatttaggg   6240

tgattttaaa gaacagtgag aaagggcata catccacaga ttcactttgt ttatgcatat   6300

gtagatacaa ggatgcacat atacacattt tcaaggacta ttttagatat ctagacaatt   6360

tcttctaata aagtcatttg tgaaagggta ctacagctta ttgacatcag taaggtagca   6420

ttcattacct gtttattctc tgctgcatct tacagaagag taaactggtg agagtatata   6480

ttttatatat atatatatat atatatatat aatatgtata tatatatata ttgacttgtt   6540

acatgaagat gttaaaatcg gtttttaaag gtgatgtaaa tagtgatttc cttaatgaaa   6600

aatacatatt ttgtattgtt ctaatgcaac agaaaagcct tttaatctct ttggttcctg   6660

tatattccat gtataagtgt aaatataatc agacaggttt aaaagttgtg catgtatgta   6720

tacagttgca agtctggaca aatgtataga ataaaccttt tatttaagtt gtgattacct   6780

gctgcatgaa aagtgcatgg gggaccctgt gcatctgtgc atttggcaaa atgtcttaac   6840

aaatcagatc agatgttcat cctaacatga cagtattcca tttctggaca tgacgtctgt   6900

ggtttaagct ttgtgaaaga atgtgctttg attcgaaggg tcttaaagaa tttttttaat   6960

cgtcaaccac ttttaaacat aaagaattca cacaactact ttcatgaatt ttttaatccc   7020

attgcaaaca ttattccaag agtatcccag tattagcaat actggaatat aggcacatta   7080

ccattcatag taagaattct ggtgtttaca caaccaaatt tgatgcgatc tgctcagtaa   7140

tataatttgc catttttatt agaaatttaa tttcttcatg tgatgtcatg aaactgtaca   7200

tactgcagtg tgaatttttt tgttttgttt tttaatcttt tagtgtttac ttcctgcagt   7260

gaatttgaat aaatgagaaa aaatgcattg tc                                 7292


<210>  1301
<211>  1158
<212>  PRT
<213>  Homo sapiens

<400>  1301

Met Thr His Gly Glu Glu Leu Gly Ser Asp Val His Gln Asp Ser Ile 
1               5                   10                  15


Val Leu Thr Tyr Leu Glu Gly Leu Leu Met His Gln Ala Ala Gly Gly 
            20                  25                  30


Ser Gly Thr Ala Val Asp Lys Lys Ser Ala Gly His Asn Glu Glu Asp 
        35                  40                  45


Gln Asn Phe Asn Ile Ser Gly Ser Ala Phe Pro Thr Cys Gln Ser Asn 
    50                  55                  60


Gly Pro Val Leu Asn Thr His Thr Tyr Gln Gly Ser Gly Met Leu His 
65                  70                  75                  80


Leu Lys Lys Ala Arg Leu Leu Gln Ser Ser Glu Asp Trp Asn Ala Ala 
                85                  90                  95


Lys Arg Lys Arg Leu Ser Asp Ser Ile Met Asn Leu Asn Val Lys Lys 
            100                 105                 110


Glu Ala Leu Leu Ala Gly Met Val Asp Ser Val Pro Lys Gly Lys Gln 
        115                 120                 125


Asp Ser Thr Leu Leu Ala Ser Leu Leu Gln Ser Phe Ser Ser Arg Leu 
    130                 135                 140


Gln Thr Val Ala Leu Ser Gln Gln Ile Arg Gln Ser Leu Lys Glu Gln 
145                 150                 155                 160


Gly Tyr Ala Leu Ser His Asp Ser Leu Lys Val Glu Lys Asp Leu Arg 
                165                 170                 175


Cys Tyr Gly Val Ala Ser Ser His Leu Lys Thr Leu Leu Lys Lys Ser 
            180                 185                 190


Lys Val Lys Asp Gln Lys Pro Asp Thr Asn Leu Pro Asp Val Thr Lys 
        195                 200                 205


Asn Leu Ile Arg Asp Arg Phe Ala Glu Ser Pro His His Val Gly Gln 
    210                 215                 220


Ser Gly Thr Lys Val Met Ser Glu Pro Leu Ser Cys Ala Ala Arg Leu 
225                 230                 235                 240


Gln Ala Val Ala Ser Met Val Glu Lys Arg Ala Ser Pro Ala Thr Ser 
                245                 250                 255


Pro Lys Pro Ser Val Ala Cys Ser Gln Leu Ala Leu Leu Leu Ser Ser 
            260                 265                 270


Glu Ala His Leu Gln Gln Tyr Ser Arg Glu His Ala Leu Lys Thr Gln 
        275                 280                 285


Asn Ala Asn Gln Ala Ala Ser Glu Arg Leu Ala Ala Met Ala Arg Leu 
    290                 295                 300


Gln Glu Asn Gly Gln Lys Asp Val Gly Ser Tyr Gln Leu Pro Lys Gly 
305                 310                 315                 320


Met Ser Ser His Leu Asn Gly Gln Ala Arg Thr Ser Ser Ser Lys Leu 
                325                 330                 335


Met Ala Ser Lys Ser Ser Ala Thr Val Phe Gln Asn Pro Met Gly Ile 
            340                 345                 350


Ile Pro Ser Ser Pro Lys Asn Ala Gly Tyr Lys Asn Ser Leu Glu Arg 
        355                 360                 365


Asn Asn Ile Lys Gln Ala Ala Asn Asn Ser Leu Leu Leu His Leu Leu 
    370                 375                 380


Lys Ser Gln Thr Ile Pro Lys Pro Met Asn Gly His Ser His Ser Glu 
385                 390                 395                 400


Arg Gly Ser Ile Phe Glu Glu Ser Ser Thr Pro Thr Thr Ile Asp Glu 
                405                 410                 415


Tyr Ser Asp Asn Asn Pro Ser Phe Thr Asp Asp Ser Ser Gly Asp Glu 
            420                 425                 430


Ser Ser Tyr Ser Asn Cys Val Pro Ile Asp Leu Ser Cys Lys His Arg 
        435                 440                 445


Thr Glu Lys Ser Glu Ser Asp Gln Pro Val Ser Leu Asp Asn Phe Thr 
    450                 455                 460


Gln Ser Leu Leu Asn Thr Trp Asp Pro Lys Val Pro Asp Val Asp Ile 
465                 470                 475                 480


Lys Glu Asp Gln Asp Thr Ser Lys Asn Ser Lys Leu Asn Ser His Gln 
                485                 490                 495


Lys Val Thr Leu Leu Gln Leu Leu Leu Gly His Lys Asn Glu Glu Asn 
            500                 505                 510


Val Glu Lys Asn Thr Ser Pro Gln Gly Val His Asn Asp Val Ser Lys 
        515                 520                 525


Phe Asn Thr Gln Asn Tyr Ala Arg Thr Ser Val Ile Glu Ser Pro Ser 
    530                 535                 540


Thr Asn Arg Thr Thr Pro Val Ser Thr Pro Pro Leu Leu Thr Ser Ser 
545                 550                 555                 560


Lys Ala Gly Ser Pro Ile Asn Leu Ser Gln His Ser Leu Val Ile Lys 
                565                 570                 575


Trp Asn Ser Pro Pro Tyr Val Cys Ser Thr Gln Ser Glu Lys Leu Thr 
            580                 585                 590


Asn Thr Ala Ser Asn His Ser Met Asp Leu Thr Lys Ser Lys Asp Pro 
        595                 600                 605


Pro Gly Glu Lys Pro Ala Gln Asn Glu Gly Ala Gln Asn Ser Ala Thr 
    610                 615                 620


Phe Ser Ala Ser Lys Leu Leu Gln Asn Leu Ala Gln Cys Gly Met Gln 
625                 630                 635                 640


Ser Ser Met Ser Val Glu Glu Gln Arg Pro Ser Lys Gln Leu Leu Thr 
                645                 650                 655


Gly Asn Thr Asp Lys Pro Ile Gly Met Ile Asp Arg Leu Asn Ser Pro 
            660                 665                 670


Leu Leu Ser Asn Lys Thr Asn Ala Val Glu Glu Asn Lys Ala Phe Ser 
        675                 680                 685


Ser Gln Pro Thr Gly Pro Glu Pro Gly Leu Ser Gly Ser Glu Ile Glu 
    690                 695                 700


Asn Leu Leu Glu Arg Arg Thr Val Leu Gln Leu Leu Leu Gly Asn Pro 
705                 710                 715                 720


Asn Lys Gly Lys Ser Glu Lys Lys Glu Lys Thr Pro Leu Arg Asp Glu 
                725                 730                 735


Ser Thr Gln Glu His Ser Glu Arg Ala Leu Ser Glu Gln Ile Leu Met 
            740                 745                 750


Val Lys Ile Lys Ser Glu Pro Cys Asp Asp Leu Gln Ile Pro Asn Thr 
        755                 760                 765


Asn Val His Leu Ser His Asp Ala Lys Ser Ala Pro Phe Leu Gly Met 
    770                 775                 780


Ala Pro Ala Val Gln Arg Ser Ala Pro Ala Leu Pro Val Ser Glu Asp 
785                 790                 795                 800


Phe Lys Ser Glu Pro Val Ser Pro Gln Asp Phe Ser Phe Ser Lys Asn 
                805                 810                 815


Gly Leu Leu Ser Arg Leu Leu Arg Gln Asn Gln Asp Ser Tyr Leu Ala 
            820                 825                 830


Asp Asp Ser Asp Arg Ser His Arg Asn Asn Glu Met Ala Leu Leu Glu 
        835                 840                 845


Ser Lys Asn Leu Cys Met Val Pro Lys Lys Arg Lys Leu Tyr Thr Glu 
    850                 855                 860


Pro Leu Glu Asn Pro Phe Lys Lys Met Lys Asn Asn Ile Val Asp Ala 
865                 870                 875                 880


Ala Asn Asn His Ser Ala Pro Glu Val Leu Tyr Gly Ser Leu Leu Asn 
                885                 890                 895


Gln Glu Glu Leu Lys Phe Ser Arg Asn Asp Leu Glu Phe Lys Tyr Pro 
            900                 905                 910


Ala Gly His Gly Ser Ala Ser Glu Ser Glu His Arg Ser Trp Ala Arg 
        915                 920                 925


Glu Ser Lys Ser Phe Asn Val Leu Lys Gln Leu Leu Leu Ser Glu Asn 
    930                 935                 940


Cys Val Arg Asp Leu Ser Pro His Arg Ser Asn Ser Val Ala Asp Ser 
945                 950                 955                 960


Lys Lys Lys Gly His Lys Asn Asn Val Thr Asn Ser Lys Pro Glu Phe 
                965                 970                 975


Ser Ile Ser Ser Leu Asn Gly Leu Met Tyr Ser Ser Thr Gln Pro Ser 
            980                 985                 990


Ser Cys Met Asp Asn Arg Thr Phe Ser Tyr Pro Gly Val Val Lys Thr 
        995                 1000                1005


Pro Val Ser Pro Thr Phe Pro Glu His Leu Gly Cys Ala Gly Ser Arg 
    1010                1015                1020


Pro Glu Ser Gly Leu Leu Asn Gly Cys Ser Met Pro Ser Glu Lys Gly 
1025                1030                1035                1040


Pro Ile Lys Trp Val Ile Thr Asp Ala Glu Lys Asn Glu Tyr Glu Lys 
                1045                1050                1055


Asp Ser Pro Arg Leu Thr Lys Thr Asn Pro Ile Leu Tyr Tyr Met Leu 
            1060                1065                1070


Gln Lys Gly Gly Asn Ser Val Thr Ser Arg Glu Thr Gln Asp Lys Asp 
        1075                1080                1085


Ile Trp Arg Glu Ala Ser Ser Ala Glu Ser Val Ser Gln Val Thr Ala 
    1090                1095                1100


Lys Glu Glu Leu Leu Pro Thr Ala Glu Thr Lys Ala Ser Phe Phe Asn 
1105                1110                1115                1120


Leu Arg Ser Pro Tyr Asn Ser His Met Gly Asn Asn Ala Ser Arg Pro 
                1125                1130                1135


His Ser Ala Asn Gly Glu Val Tyr Gly Leu Leu Gly Ser Val Leu Thr 
            1140                1145                1150


Ile Lys Lys Glu Ser Glu 
        1155


<210>  1302
<211>  1382
<212>  DNA
<213>  Homo sapiens

<400>  1302
gcgggaccgg ccgcgtctcc atggcgacgc gggacgcggc ggtggaggcg gttgctaccc     60

acctgctaga ggcgctgcgg ctgtgatcca ggctggggcg agaccatgtc ggacctgggc    120

tcggaggagt tggaggagga gggagagaat gatattgggg aatatgaggg gggtcggaat    180

gaggcaggcg aaaggcacgg acgtgggagg gcacggctac ccaacgggga cacctacgaa    240

gggagctacg aattcggtaa aagacatggc caggggatct acaaatttaa aaatggtgct    300

cgatatatcg gagaatatgt tagaaataaa aagcacggtc aaggcacttt tatatatcca    360

gatggatcca gatatgaagg agagtgggca aatgacctgc ggcacggcca tggcgtatac    420

tactacatca ataatgacac ctacactgga gagtggtttg ctcatcaaag gcatgggcaa    480

ggcacctatt tatacgcgga gacgggcagt aagtatgttg gcacctgggt gaacggacag    540

caggagggca cggccgagct cattcacctg aaccacaggt accagggcaa gttcttgaac    600

aaaaatcctg ttggccctgg aaagtatgta tttgatgttg ggtgtgaaca acatggtgaa    660

tatcgtttaa cagatatgga aagaggagaa gaggaagagg aggaagaatt agtaactgtt    720

gttccaaaat ggaaagctac ccaaatcact gaattggccc tgtggacacc aactctcccc    780

aaaaagccga cctctacgga tggacctggc caagacgctc caggagctga gagtgcagga    840

gaacccgggg aggaggccca ggctctgctg gagggcttcg agggtgagat ggacatgagg    900

cctggagatg aagatgcaga cgtcctccgg gaagagagcc gggagtatga ccaggaggag    960

ttccgctatg acatggatga gggaaacatt aattctgaag aagaagaaac tagacagtca   1020

gacctccagg actaagatga agtgagccga gaggagatcg tatcataaga atgcttctgt   1080

cgttagccgg gtgcagtgct gtgtgtatct agttccagct acttgagagg ctgaggcagg   1140

aggattgctt gagtccagaa agtggcagtt gcagtgagtg gagatcgcgc cactgctctc   1200

cagcctgggt ggcagagcga gaccctgtct caaaaaataa acaaaaacaa aatgcttctg   1260

tcagttaaca atctttatta gagggttttt agtctttctt tctcagctgt atgttaagtt   1320

gattgacaaa tgcaaataaa cgtctttatt atcctttctt tctgaaaaaa aaaaaaaaaa   1380

aa                                                                  1382


<210>  1303
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  1303

Met Ser Asp Leu Gly Ser Glu Glu Leu Glu Glu Glu Gly Glu Asn Asp 
1               5                   10                  15


Ile Gly Glu Tyr Glu Gly Gly Arg Asn Glu Ala Gly Glu Arg His Gly 
            20                  25                  30


Arg Gly Arg Ala Arg Leu Pro Asn Gly Asp Thr Tyr Glu Gly Ser Tyr 
        35                  40                  45


Glu Phe Gly Lys Arg His Gly Gln Gly Ile Tyr Lys Phe Lys Asn Gly 
    50                  55                  60


Ala Arg Tyr Ile Gly Glu Tyr Val Arg Asn Lys Lys His Gly Gln Gly 
65                  70                  75                  80


Thr Phe Ile Tyr Pro Asp Gly Ser Arg Tyr Glu Gly Glu Trp Ala Asn 
                85                  90                  95


Asp Leu Arg His Gly His Gly Val Tyr Tyr Tyr Ile Asn Asn Asp Thr 
            100                 105                 110


Tyr Thr Gly Glu Trp Phe Ala His Gln Arg His Gly Gln Gly Thr Tyr 
        115                 120                 125


Leu Tyr Ala Glu Thr Gly Ser Lys Tyr Val Gly Thr Trp Val Asn Gly 
    130                 135                 140


Gln Gln Glu Gly Thr Ala Glu Leu Ile His Leu Asn His Arg Tyr Gln 
145                 150                 155                 160


Gly Lys Phe Leu Asn Lys Asn Pro Val Gly Pro Gly Lys Tyr Val Phe 
                165                 170                 175


Asp Val Gly Cys Glu Gln His Gly Glu Tyr Arg Leu Thr Asp Met Glu 
            180                 185                 190


Arg Gly Glu Glu Glu Glu Glu Glu Glu Leu Val Thr Val Val Pro Lys 
        195                 200                 205


Trp Lys Ala Thr Gln Ile Thr Glu Leu Ala Leu Trp Thr Pro Thr Leu 
    210                 215                 220


Pro Lys Lys Pro Thr Ser Thr Asp Gly Pro Gly Gln Asp Ala Pro Gly 
225                 230                 235                 240


Ala Glu Ser Ala Gly Glu Pro Gly Glu Glu Ala Gln Ala Leu Leu Glu 
                245                 250                 255


Gly Phe Glu Gly Glu Met Asp Met Arg Pro Gly Asp Glu Asp Ala Asp 
            260                 265                 270


Val Leu Arg Glu Glu Ser Arg Glu Tyr Asp Gln Glu Glu Phe Arg Tyr 
        275                 280                 285


Asp Met Asp Glu Gly Asn Ile Asn Ser Glu Glu Glu Glu Thr Arg Gln 
    290                 295                 300


Ser Asp Leu Gln Asp 
305


<210>  1304
<211>  605
<212>  DNA
<213>  Homo sapiens

<400>  1304
atggagacgc ggccggtccc gcctccctcc cagcccggaa gatggggagc ggggacaggc     60

gacgcggacg aagcgggagg agccactggc agcctttgcc aacgaggggc cgcttcggcc    120

aatcactgct cgggaagcga gggggcgggg actgggcagg gcctgagcgg gttctgtgcc    180

tggctgccca ccggctctct gacctggacc tcgccgtcgc tggcccctga aatccatcac    240

ttttgtcggc tgttctgtga cgccacaacg aggagccacc tgggctctgc tgacccttcg    300

ggattcgcgg ctagctgtga tgtgtccgcc aagatctctt ctcttgtctg taaacaactt    360

cactctcaag gaggcagctc tggcctctca gcaggagctg gggaggagtg actgaataac    420

tataggattt ggtcttgatg ggagaatccc agaagccaaa tccacgcggt gaataagctg    480

ctgatcttcc agagcacaca tcccctagag attcttccca atgctaatat gaaaggttac    540

aaccataacc catcatcagg cccaaatata ttacttactg aataaataca caagttacaa    600

caaca                                                                605


<210>  1305
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  1305

Met Glu Thr Arg Pro Val Pro Pro Pro Ser Gln Pro Gly Arg Trp Gly 
1               5                   10                  15


Ala Gly Thr Gly Asp Ala Asp Glu Ala Gly Gly Ala Thr Gly Ser Leu 
            20                  25                  30


Cys Gln Arg Gly Ala Ala Ser Ala Asn His Cys Ser Gly Ser Glu Gly 
        35                  40                  45


Ala Gly Thr Gly Gln Gly Leu Ser Gly Phe Cys Ala Trp Leu Pro Thr 
    50                  55                  60


Gly Ser Leu Thr Trp Thr Ser Pro Ser Leu Ala Pro Glu Ile His His 
65                  70                  75                  80


Phe Cys Arg Leu Phe Cys Asp Ala Thr Thr Arg Ser His Leu Gly Ser 
                85                  90                  95


Ala Asp Pro Ser Gly Phe Ala Ala Ser Cys Asp Val Ser Ala Lys Ile 
            100                 105                 110


Ser Ser Leu Val Cys Lys Gln Leu His Ser Gln Gly Gly Ser Ser Gly 
        115                 120                 125


Leu Ser Ala Gly Ala Gly Glu Glu 
    130                 135


<210>  1306
<211>  3098
<212>  DNA
<213>  Homo sapiens

<400>  1306
tgggaagttc gcgcaagtgc ggctctgcag ggaggaggga gggccgaggg gaaggccctc     60

gagagagtgg agggcaacag tggccacggt tcctctgtac ttcgtttctt ccctttatag    120

aattgagaga ttgctgagcc taaatacatg ttgctgcatt gcctccgaga atggccggac    180

ctatccccac tctcaccaaa acagagtgtg ggactcactg ctccctcgcc tactagagca    240

gagccactgc cagaaggaag gggacaagac ccagcaggac accttctttc cacgctttcc    300

agcctgtggg agcggcaggg gcaacagaga gaggatctgg agccaggatt aatgactcat    360

ttatgaagca tcttattctg cgaccgaggc tcagtggtca gtggcgacgt aaatggctcg    420

actccccgct ggcattcgct tcatcatctc attctccagg gatcagtggt acagagcctt    480

catttttatt ttgacatttc tgctgtatgc aagttttcac ttatctcgaa agcctatcag    540

catagttaag ggtgagctcc acaagtactg cactgcttgg gatgaagctg acgtcaggtt    600

cagcagccag aacaggaagt ctgggtccgc tgccccccac cagctccctg acaatgagac    660

cgactgtggc tgggcaccgt ttgataagaa caactatcag cagctgcttg gggccctgga    720

ctactccttc ctgtgcgcct atgccgtggg gatgtacctc agtggcatca ttggggagcg    780

cctgccgatt aggtattacc taactttcgg gatgctcgcc agcggagcct tcaccgccct    840

gttcggctta gggtatttct acaacatcca cagtttcgga ttctacgtgg taactcaggt    900

catcaacggg ctggtgcaga ccaccggctg gcccagcgtc gtcacctgcc tcggcaactg    960

gtttggaaaa ggaaggagag gtttgattat gggggtctgg aactcccaca cctccgtggg   1020

caacatcttg gggtcattga tcgctggcta ctgggtgtcc acatgctggg gcctgtcctt   1080

cgtcgtgcct ggagccatcg tggcagccat ggggatagtg tgctttctct tcctcattga   1140

acatccgaac gacgtcaggt gctcctccac cctggtgacg cactcaaaag gctatgagaa   1200

tggtacaaac agattgagac tccagaagca aatcttgaag agcgaaaaga acaagcctct   1260

ggacccagag atgcagtgcc tgctgctctc agatgggaag ggctccatcc acccgaacca   1320

cgtcgtcatt ctccccgggg acggtgggag tggcacggcc gccatcagct tcacaggggc   1380

cttgaaaatt ccaggcgtga tagagttctc actgtgtctg ctgtttgcca agctggtcag   1440

ctatactttc ctcttctggc tgcccctgta catcacgaat gtggatcacc ttgatgccaa   1500

aaaggcgggg gagctctcca ccctgtttga cgtgggcgga atctttggtg ggatcctggc   1560

aggtgtgatc tcagaccgac tggagaaaag ggcctccacc tgcggcctga tgctgctgct   1620

cgcggccccc acgctctaca tcttctccac cgtcagcaag atggggcttg aggccaccat   1680

cgccatgctg ctgctcagcg gagccctggt cagtgggccc tacacactca tcaccaccgc   1740

cgtctccgcc gacctgggga ctcataaaag tctgaaaggc aacgcgcacg ccctctccac   1800

cgtgacggcc atcattgacg ggacgggctc tgtaggagca gccctgggcc ccctgctggc   1860

tgggctcctc tccccgtccg gctggagcaa tgtgttttac atgctgatgt ttgcagatgc   1920

ctgtgcctta ctgttcctga tccgcctcat acacaaggag ctgagctgcc cagggtcagc   1980

tacgggggac caagttccat ttaaggaaca gtgacacccc accccagtcc cgtggagggg   2040

gtctgggccc acccttcaca actgcctttc aaggacagtt cagacaaagg gccctgcatg   2100

gaaagagtga cctccctttg ccttttgcac acgcacctgg aaaagacaca gaagccaacc   2160

tgagaacccc tggtgctatt ttaaaggaga catattgctg aacagcagtg agaaaagtct   2220

gcaggaactg ctgcctgagc caagccagag aaccgaagac ccggccggcc ctggcctcac   2280

aggcgtgtgc ccatgcagcc acccaaatgc acgcgtgaca acaaggccgg gagggtgggg   2340

ggggtgcaca ggtagccccg accctctcag gcattccagc cacagaacat caaagtgagc   2400

gagtactgcg ctggctgtgg cttcagagaa cctgtatgtg ccacatggaa aaacaggaca   2460

ccagagccca ccagacagtg ccggccagca gagaagcaga gagccagcgc cacacaacat   2520

caagaaggcc gacaaccagg ttggaaacca agacggagct cagacccacc acatcgcccc   2580

agaggctttt ccagcaccca tgatgtttcg gactgaccta aaaactaatt gtcgagaagc   2640

caagggtgag gaggcaggaa gcacctccgg ttggaggcac ccaggcttgc cagccacaga   2700

gcgccccaaa gtcaccgtca tcccagcccc tggccttcct gctgccctcc ggggccatgg   2760

cactgctgtt cagctcaggc acaggggcac agcagaggtt tgggaagcgg tctccccacc   2820

ggcactggga ttggcgggtc caagcccagc aaccggcttc gctccacaac acacaccaca   2880

cctgggactg tttttaatac atagcaacag actgggttat ttatttaaga tgtgtattgt   2940

gtcatatgaa gtttaagaga cataaatggc attttgttat ttattaagac aaactccaat   3000

tgttctctgg ctgttttttt cagttgtgtc tagcaaaata cttatctgcc ctttgaaata   3060

aaatgttttt gtttaaaaaa tctcagaaca ctcaaaaa                           3098


<210>  1307
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  1307

Met Ala Arg Leu Pro Ala Gly Ile Arg Phe Ile Ile Ser Phe Ser Arg 
1               5                   10                  15


Asp Gln Trp Tyr Arg Ala Phe Ile Phe Ile Leu Thr Phe Leu Leu Tyr 
            20                  25                  30


Ala Ser Phe His Leu Ser Arg Lys Pro Ile Ser Ile Val Lys Gly Glu 
        35                  40                  45


Leu His Lys Tyr Cys Thr Ala Trp Asp Glu Ala Asp Val Arg Phe Ser 
    50                  55                  60


Ser Gln Asn Arg Lys Ser Gly Ser Ala Ala Pro His Gln Leu Pro Asp 
65                  70                  75                  80


Asn Glu Thr Asp Cys Gly Trp Ala Pro Phe Asp Lys Asn Asn Tyr Gln 
                85                  90                  95


Gln Leu Leu Gly Ala Leu Asp Tyr Ser Phe Leu Cys Ala Tyr Ala Val 
            100                 105                 110


Gly Met Tyr Leu Ser Gly Ile Ile Gly Glu Arg Leu Pro Ile Arg Tyr 
        115                 120                 125


Tyr Leu Thr Phe Gly Met Leu Ala Ser Gly Ala Phe Thr Ala Leu Phe 
    130                 135                 140


Gly Leu Gly Tyr Phe Tyr Asn Ile His Ser Phe Gly Phe Tyr Val Val 
145                 150                 155                 160


Thr Gln Val Ile Asn Gly Leu Val Gln Thr Thr Gly Trp Pro Ser Val 
                165                 170                 175


Val Thr Cys Leu Gly Asn Trp Phe Gly Lys Gly Arg Arg Gly Leu Ile 
            180                 185                 190


Met Gly Val Trp Asn Ser His Thr Ser Val Gly Asn Ile Leu Gly Ser 
        195                 200                 205


Leu Ile Ala Gly Tyr Trp Val Ser Thr Cys Trp Gly Leu Ser Phe Val 
    210                 215                 220


Val Pro Gly Ala Ile Val Ala Ala Met Gly Ile Val Cys Phe Leu Phe 
225                 230                 235                 240


Leu Ile Glu His Pro Asn Asp Val Arg Cys Ser Ser Thr Leu Val Thr 
                245                 250                 255


His Ser Lys Gly Tyr Glu Asn Gly Thr Asn Arg Leu Arg Leu Gln Lys 
            260                 265                 270


Gln Ile Leu Lys Ser Glu Lys Asn Lys Pro Leu Asp Pro Glu Met Gln 
        275                 280                 285


Cys Leu Leu Leu Ser Asp Gly Lys Gly Ser Ile His Pro Asn His Val 
    290                 295                 300


Val Ile Leu Pro Gly Asp Gly Gly Ser Gly Thr Ala Ala Ile Ser Phe 
305                 310                 315                 320


Thr Gly Ala Leu Lys Ile Pro Gly Val Ile Glu Phe Ser Leu Cys Leu 
                325                 330                 335


Leu Phe Ala Lys Leu Val Ser Tyr Thr Phe Leu Phe Trp Leu Pro Leu 
            340                 345                 350


Tyr Ile Thr Asn Val Asp His Leu Asp Ala Lys Lys Ala Gly Glu Leu 
        355                 360                 365


Ser Thr Leu Phe Asp Val Gly Gly Ile Phe Gly Gly Ile Leu Ala Gly 
    370                 375                 380


Val Ile Ser Asp Arg Leu Glu Lys Arg Ala Ser Thr Cys Gly Leu Met 
385                 390                 395                 400


Leu Leu Leu Ala Ala Pro Thr Leu Tyr Ile Phe Ser Thr Val Ser Lys 
                405                 410                 415


Met Gly Leu Glu Ala Thr Ile Ala Met Leu Leu Leu Ser Gly Ala Leu 
            420                 425                 430


Val Ser Gly Pro Tyr Thr Leu Ile Thr Thr Ala Val Ser Ala Asp Leu 
        435                 440                 445


Gly Thr His Lys Ser Leu Lys Gly Asn Ala His Ala Leu Ser Thr Val 
    450                 455                 460


Thr Ala Ile Ile Asp Gly Thr Gly Ser Val Gly Ala Ala Leu Gly Pro 
465                 470                 475                 480


Leu Leu Ala Gly Leu Leu Ser Pro Ser Gly Trp Ser Asn Val Phe Tyr 
                485                 490                 495


Met Leu Met Phe Ala Asp Ala Cys Ala Leu Leu Phe Leu Ile Arg Leu 
            500                 505                 510


Ile His Lys Glu Leu Ser Cys Pro Gly Ser Ala Thr Gly Asp Gln Val 
        515                 520                 525


Pro Phe Lys Glu Gln 
    530


<210>  1308
<211>  2444
<212>  DNA
<213>  Homo sapiens

<400>  1308
agcaggaggg tgggaccaag ggtgctgctg gaccaaggat gggactgggc caagggtggg     60

gctgggaagc atcctgtttt gcatgtttga tcaggagctg ctgccaagtt gtgactttca    120

ctttcccttt tgggttccag ggtatatctc agagcctgga gaacgtgtct ggttattatg    180

cagatgcacg gctggaggtg ggatccacac agctcagaac agctggatct tgctcacact    240

ctttcaagag aagcttcctt ggacaaaagg accctgcctt ggtgtgagag tgagggcaga    300

gggagctgga gcaagtagaa tttctctaaa taccagctgg ctggggccca ggagattaaa    360

aaacaccggg ctaggttggt cttggcattt gctgacacgc aaagggattg cagagatcca    420

gcccctccaa cctccctctg tccacaggtg gctcacattc agtcccacaa tttgctttct    480

cctcctcaag ggttaagaaa aaaaacgaac ccttccagtc aggtcagtga ctggagagct    540

ccatggaaag tctctcagtg acctggctgc tggcaccatg gactcagaaa agaaacgctt    600

tactgaagag gccaccaaat acttccggga gagagtcagc ccagtgcatc tgcaaatcct    660

gctgactaac aatgaagcct ggaagagatt cgtgactgcg gctgaattgc ccagggatga    720

ggcagatgct ctctacgaag ctctgaagaa gcttagaaca tatgcagcta ttgaggacga    780

atatgtgcag cagaaagatg agcagtttag ggaatggttt ttgaaagagt ttccccaagt    840

caagaggaag atccaggagt ccatagaaaa gcttcgtgcc cttgcaaatg gtattgaaga    900

ggtccacaga ggctgcacca tctccaatgt ggtgtccagc tccactggcg ctgcctctgg    960

catcatgtcc cttgctggtc ttgttttggc accatttaca gcagggacga gtctggccct   1020

tactgcagct ggggtagggc tgggagcagc gtctgctgtg actgggatca ccaccagcat   1080

cgtggagcac tcatacacat catcagcaga agctgaagcc agcaggctga ctgcaaccag   1140

cattgaccga ttgaaggtat ttaaggaagt tatgcgtgac atcacaccca acttactttc   1200

ccttcttaat aattattacg aagccacaca aaccattggg agtgaaatcc gtgccatcag   1260

gcaagccaga gccagggccc gactccctgt gaccacctgg cgaatctcag ctggaagtgg   1320

tggtcaagca gagagaacga ttgcaggcac cacccgggca gtgagcagag gagcccggat   1380

cctgagtgcg accacttcag gcatcttcct tgcactggat gtggtcaacc ttgtatacga   1440

gtcaaagcac ttgcatgagg gggcaaagtc tgcatctgct gaggagctga ggcggcaggc   1500

tcaggagctg gaggagaatc taatggagct cactcagatc tatcagcgtc tgaatccatg   1560

ccatacccac tgaccccaga ccagtgcagc cagcagggga ggtgagccat acacaggcca   1620

cgacaaaatg caggcatttt attaggggga taaagagggc aaggtaaagt ttatggagct   1680

gagtgttagt gactttggca tttctgtagc tgagcacagc aggggagggg ttaatgcaga   1740

tggcaagtgc accaaggaga aggcaggaat gctggagcct ggaataaggg aggagagggg   1800

actggagagt gtggggaata ggaagaagaa atttccttta gactaacgaa tatattgggg   1860

ggaggaatag aggggaggtg tgcaggaacc agcaatgaga aggccaggaa aagaaagagc   1920

tgaaaatgca gaaagccgaa gagttagaac ttttggatac agcagaagaa acagcggctc   1980

cactaccgac ctgcccccgg ttcgatgtcc ttccaagaat gaagtctttc cctggtgatg   2040

gtcccctgcc ctgtctttcc agcatccact ctgtcttgtc ctcctggaag tgtatctcag   2100

tcagccagtg gcttcttgat gatggcggtg gaggtggtgg ttgtagtgtg atggatcccc   2160

tttaggttat ttaggggtat atgtcccctg cttgaaccct gaaggccagg taatgagcca   2220

tggccattgt ccccagctga ggaccaggtg tctctaaaaa cccaaacatc ctggagagta   2280

tgcgagaacc taccaagaaa aacagtctca ttactcatat acagcaggca aagagacaga   2340

aaattaactg aaaagcagtt tagagactgg gggaggccgg atctctagag ccatcctgct   2400

gagtgccctg tgtgtaagtc ctaataaact cacctactca ccaa                    2444


<210>  1309
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  1309

Met Asp Ser Glu Lys Lys Arg Phe Thr Glu Glu Ala Thr Lys Tyr Phe 
1               5                   10                  15


Arg Glu Arg Val Ser Pro Val His Leu Gln Ile Leu Leu Thr Asn Asn 
            20                  25                  30


Glu Ala Trp Lys Arg Phe Val Thr Ala Ala Glu Leu Pro Arg Asp Glu 
        35                  40                  45


Ala Asp Ala Leu Tyr Glu Ala Leu Lys Lys Leu Arg Thr Tyr Ala Ala 
    50                  55                  60


Ile Glu Asp Glu Tyr Val Gln Gln Lys Asp Glu Gln Phe Arg Glu Trp 
65                  70                  75                  80


Phe Leu Lys Glu Phe Pro Gln Val Lys Arg Lys Ile Gln Glu Ser Ile 
                85                  90                  95


Glu Lys Leu Arg Ala Leu Ala Asn Gly Ile Glu Glu Val His Arg Gly 
            100                 105                 110


Cys Thr Ile Ser Asn Val Val Ser Ser Ser Thr Gly Ala Ala Ser Gly 
        115                 120                 125


Ile Met Ser Leu Ala Gly Leu Val Leu Ala Pro Phe Thr Ala Gly Thr 
    130                 135                 140


Ser Leu Ala Leu Thr Ala Ala Gly Val Gly Leu Gly Ala Ala Ser Ala 
145                 150                 155                 160


Val Thr Gly Ile Thr Thr Ser Ile Val Glu His Ser Tyr Thr Ser Ser 
                165                 170                 175


Ala Glu Ala Glu Ala Ser Arg Leu Thr Ala Thr Ser Ile Asp Arg Leu 
            180                 185                 190


Lys Val Phe Lys Glu Val Met Arg Asp Ile Thr Pro Asn Leu Leu Ser 
        195                 200                 205


Leu Leu Asn Asn Tyr Tyr Glu Ala Thr Gln Thr Ile Gly Ser Glu Ile 
    210                 215                 220


Arg Ala Ile Arg Gln Ala Arg Ala Arg Ala Arg Leu Pro Val Thr Thr 
225                 230                 235                 240


Trp Arg Ile Ser Ala Gly Ser Gly Gly Gln Ala Glu Arg Thr Ile Ala 
                245                 250                 255


Gly Thr Thr Arg Ala Val Ser Arg Gly Ala Arg Ile Leu Ser Ala Thr 
            260                 265                 270


Thr Ser Gly Ile Phe Leu Ala Leu Asp Val Val Asn Leu Val Tyr Glu 
        275                 280                 285


Ser Lys His Leu His Glu Gly Ala Lys Ser Ala Ser Ala Glu Glu Leu 
    290                 295                 300


Arg Arg Gln Ala Gln Glu Leu Glu Glu Asn Leu Met Glu Leu Thr Gln 
305                 310                 315                 320


Ile Tyr Gln Arg Leu Asn Pro Cys His Thr His 
                325                 330


<210>  1310
<211>  2328
<212>  DNA
<213>  Homo sapiens

<400>  1310
agcaggaggg tgggaccaag ggtgctgctg gaccaaggat gggactgggc caagggtggg     60

gctgggaagc atcctgtttt gcatgtttga tcaggagctg ctgccaagtt gtgactttca    120

ctttcccttt tgggttccag ggtatatctc agagcctgga gaacgtgtct ggttattatg    180

cagatgcacg gctggaggtg ggatccacac agctcagaac agctggatct tgctcacact    240

ctttcaagag aagcttcctt ggacaaaagg accctgcctt ggtgtgagag tgagggcaga    300

gggagctgga gcaagtagaa tttctctaaa taccagctgg ctggggccca ggagattaaa    360

aaacaccggg ctagggttaa gaaaaaaaac gaacccttcc agtcaggtca gtgactggag    420

agctccatgg aaagtctctc agtgacctgg ctgctggcac catggactca gaaaagaaac    480

gctttactga agaggccacc aaatacttcc gggagagagt cagcccagtg catctgcaaa    540

tcctgctgac taacaatgaa gcctggaaga gattcgtgac tgcggctgaa ttgcccaggg    600

atgaggcaga tgctctctac gaagctctga agaagcttag aacatatgca gctattgagg    660

acgaatatgt gcagcagaaa gatgagcagt ttagggaatg gtttttgaaa gagtttcccc    720

aagtcaagag gaagatccag gagtccatag aaaagcttcg tgcccttgca aatggtattg    780

aagaggtcca cagaggctgc accatctcca atgtggtgtc cagctccact ggcgctgcct    840

ctggcatcat gtcccttgct ggtcttgttt tggcaccatt tacagcaggg acgagtctgg    900

cccttactgc agctggggta gggctgggag cagcgtctgc tgtgactggg atcaccacca    960

gcatcgtgga gcactcatac acatcatcag cagaagctga agccagcagg ctgactgcaa   1020

ccagcattga ccgattgaag gtatttaagg aagttatgcg tgacatcaca cccaacttac   1080

tttcccttct taataattat tacgaagcca cacaaaccat tgggagtgaa atccgtgcca   1140

tcaggcaagc cagagccagg gcccgactcc ctgtgaccac ctggcgaatc tcagctggaa   1200

gtggtggtca agcagagaga acgattgcag gcaccacccg ggcagtgagc agaggagccc   1260

ggatcctgag tgcgaccact tcaggcatct tccttgcact ggatgtggtc aaccttgtat   1320

acgagtcaaa gcacttgcat gagggggcaa agtctgcatc tgctgaggag ctgaggcggc   1380

aggctcagga gctggaggag aatctaatgg agctcactca gatctatcag cgtctgaatc   1440

catgccatac ccactgaccc cagaccagtg cagccagcag gggaggtgag ccatacacag   1500

gccacgacaa aatgcaggca ttttattagg gggataaaga gggcaaggta aagtttatgg   1560

agctgagtgt tagtgacttt ggcatttctg tagctgagca cagcagggga ggggttaatg   1620

cagatggcaa gtgcaccaag gagaaggcag gaatgctgga gcctggaata agggaggaga   1680

ggggactgga gagtgtgggg aataggaaga agaaatttcc tttagactaa cgaatatatt   1740

ggggggagga atagagggga ggtgtgcagg aaccagcaat gagaaggcca ggaaaagaaa   1800

gagctgaaaa tgcagaaagc cgaagagtta gaacttttgg atacagcaga agaaacagcg   1860

gctccactac cgacctgccc ccggttcgat gtccttccaa gaatgaagtc tttccctggt   1920

gatggtcccc tgccctgtct ttccagcatc cactctgtct tgtcctcctg gaagtgtatc   1980

tcagtcagcc agtggcttct tgatgatggc ggtggaggtg gtggttgtag tgtgatggat   2040

cccctttagg ttatttaggg gtatatgtcc cctgcttgaa ccctgaaggc caggtaatga   2100

gccatggcca ttgtccccag ctgaggacca ggtgtctcta aaaacccaaa catcctggag   2160

agtatgcgag aacctaccaa gaaaaacagt ctcattactc atatacagca ggcaaagaga   2220

cagaaaatta actgaaaagc agtttagaga ctgggggagg ccggatctct agagccatcc   2280

tgctgagtgc cctgtgtgta agtcctaata aactcaccta ctcaccaa                2328


<210>  1311
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  1311

Met Asp Ser Glu Lys Lys Arg Phe Thr Glu Glu Ala Thr Lys Tyr Phe 
1               5                   10                  15


Arg Glu Arg Val Ser Pro Val His Leu Gln Ile Leu Leu Thr Asn Asn 
            20                  25                  30


Glu Ala Trp Lys Arg Phe Val Thr Ala Ala Glu Leu Pro Arg Asp Glu 
        35                  40                  45


Ala Asp Ala Leu Tyr Glu Ala Leu Lys Lys Leu Arg Thr Tyr Ala Ala 
    50                  55                  60


Ile Glu Asp Glu Tyr Val Gln Gln Lys Asp Glu Gln Phe Arg Glu Trp 
65                  70                  75                  80


Phe Leu Lys Glu Phe Pro Gln Val Lys Arg Lys Ile Gln Glu Ser Ile 
                85                  90                  95


Glu Lys Leu Arg Ala Leu Ala Asn Gly Ile Glu Glu Val His Arg Gly 
            100                 105                 110


Cys Thr Ile Ser Asn Val Val Ser Ser Ser Thr Gly Ala Ala Ser Gly 
        115                 120                 125


Ile Met Ser Leu Ala Gly Leu Val Leu Ala Pro Phe Thr Ala Gly Thr 
    130                 135                 140


Ser Leu Ala Leu Thr Ala Ala Gly Val Gly Leu Gly Ala Ala Ser Ala 
145                 150                 155                 160


Val Thr Gly Ile Thr Thr Ser Ile Val Glu His Ser Tyr Thr Ser Ser 
                165                 170                 175


Ala Glu Ala Glu Ala Ser Arg Leu Thr Ala Thr Ser Ile Asp Arg Leu 
            180                 185                 190


Lys Val Phe Lys Glu Val Met Arg Asp Ile Thr Pro Asn Leu Leu Ser 
        195                 200                 205


Leu Leu Asn Asn Tyr Tyr Glu Ala Thr Gln Thr Ile Gly Ser Glu Ile 
    210                 215                 220


Arg Ala Ile Arg Gln Ala Arg Ala Arg Ala Arg Leu Pro Val Thr Thr 
225                 230                 235                 240


Trp Arg Ile Ser Ala Gly Ser Gly Gly Gln Ala Glu Arg Thr Ile Ala 
                245                 250                 255


Gly Thr Thr Arg Ala Val Ser Arg Gly Ala Arg Ile Leu Ser Ala Thr 
            260                 265                 270


Thr Ser Gly Ile Phe Leu Ala Leu Asp Val Val Asn Leu Val Tyr Glu 
        275                 280                 285


Ser Lys His Leu His Glu Gly Ala Lys Ser Ala Ser Ala Glu Glu Leu 
    290                 295                 300


Arg Arg Gln Ala Gln Glu Leu Glu Glu Asn Leu Met Glu Leu Thr Gln 
305                 310                 315                 320


Ile Tyr Gln Arg Leu Asn Pro Cys His Thr His 
                325                 330


<210>  1312
<211>  2215
<212>  DNA
<213>  Homo sapiens

<400>  1312
agcaggaggg tgggaccaag ggtgctgctg gaccaaggat gggactgggc caagggtggg     60

gctgggaagc atcctgtttt gcatgtttga tcaggagctg ctgccaagtt gtgactttca    120

ctttcccttt tgggttccag ggtatatctc agagcctgga gaacgtgtct ggttattatg    180

cagatgcacg gctggaggtg ggatccacac agctcagaac agctggatct tgctcacact    240

ctttcaagag aagcttcctt gggttaagaa aaaaaacgaa cccttccagt caggtcagtg    300

actggagagc tccatggaaa gtctctcagt gacctggctg ctggcaccat ggactcagaa    360

aagaaacgct ttactgaaga ggccaccaaa tacttccggg agagagtcag cccagtgcat    420

ctgcaaatcc tgctgactaa caatgaagcc tggaagagat tcgtgactgc ggctgaattg    480

cccagggatg aggcagatgc tctctacgaa gctctgaaga agcttagaac atatgcagct    540

attgaggacg aatatgtgca gcagaaagat gagcagttta gggaatggtt tttgaaagag    600

tttccccaag tcaagaggaa gatccaggag tccatagaaa agcttcgtgc ccttgcaaat    660

ggtattgaag aggtccacag aggctgcacc atctccaatg tggtgtccag ctccactggc    720

gctgcctctg gcatcatgtc ccttgctggt cttgttttgg caccatttac agcagggacg    780

agtctggccc ttactgcagc tggggtaggg ctgggagcag cgtctgctgt gactgggatc    840

accaccagca tcgtggagca ctcatacaca tcatcagcag aagctgaagc cagcaggctg    900

actgcaacca gcattgaccg attgaaggta tttaaggaag ttatgcgtga catcacaccc    960

aacttacttt cccttcttaa taattattac gaagccacac aaaccattgg gagtgaaatc   1020

cgtgccatca ggcaagccag agccagggcc cgactccctg tgaccacctg gcgaatctca   1080

gctggaagtg gtggtcaagc agagagaacg attgcaggca ccacccgggc agtgagcaga   1140

ggagcccgga tcctgagtgc gaccacttca ggcatcttcc ttgcactgga tgtggtcaac   1200

cttgtatacg agtcaaagca cttgcatgag ggggcaaagt ctgcatctgc tgaggagctg   1260

aggcggcagg ctcaggagct ggaggagaat ctaatggagc tcactcagat ctatcagcgt   1320

ctgaatccat gccataccca ctgaccccag accagtgcag ccagcagggg aggtgagcca   1380

tacacaggcc acgacaaaat gcaggcattt tattaggggg ataaagaggg caaggtaaag   1440

tttatggagc tgagtgttag tgactttggc atttctgtag ctgagcacag caggggaggg   1500

gttaatgcag atggcaagtg caccaaggag aaggcaggaa tgctggagcc tggaataagg   1560

gaggagaggg gactggagag tgtggggaat aggaagaaga aatttccttt agactaacga   1620

atatattggg gggaggaata gaggggaggt gtgcaggaac cagcaatgag aaggccagga   1680

aaagaaagag ctgaaaatgc agaaagccga agagttagaa cttttggata cagcagaaga   1740

aacagcggct ccactaccga cctgcccccg gttcgatgtc cttccaagaa tgaagtcttt   1800

ccctggtgat ggtcccctgc cctgtctttc cagcatccac tctgtcttgt cctcctggaa   1860

gtgtatctca gtcagccagt ggcttcttga tgatggcggt ggaggtggtg gttgtagtgt   1920

gatggatccc ctttaggtta tttaggggta tatgtcccct gcttgaaccc tgaaggccag   1980

gtaatgagcc atggccattg tccccagctg aggaccaggt gtctctaaaa acccaaacat   2040

cctggagagt atgcgagaac ctaccaagaa aaacagtctc attactcata tacagcaggc   2100

aaagagacag aaaattaact gaaaagcagt ttagagactg ggggaggccg gatctctaga   2160

gccatcctgc tgagtgccct gtgtgtaagt cctaataaac tcacctactc accaa        2215


<210>  1313
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  1313

Met Asp Ser Glu Lys Lys Arg Phe Thr Glu Glu Ala Thr Lys Tyr Phe 
1               5                   10                  15


Arg Glu Arg Val Ser Pro Val His Leu Gln Ile Leu Leu Thr Asn Asn 
            20                  25                  30


Glu Ala Trp Lys Arg Phe Val Thr Ala Ala Glu Leu Pro Arg Asp Glu 
        35                  40                  45


Ala Asp Ala Leu Tyr Glu Ala Leu Lys Lys Leu Arg Thr Tyr Ala Ala 
    50                  55                  60


Ile Glu Asp Glu Tyr Val Gln Gln Lys Asp Glu Gln Phe Arg Glu Trp 
65                  70                  75                  80


Phe Leu Lys Glu Phe Pro Gln Val Lys Arg Lys Ile Gln Glu Ser Ile 
                85                  90                  95


Glu Lys Leu Arg Ala Leu Ala Asn Gly Ile Glu Glu Val His Arg Gly 
            100                 105                 110


Cys Thr Ile Ser Asn Val Val Ser Ser Ser Thr Gly Ala Ala Ser Gly 
        115                 120                 125


Ile Met Ser Leu Ala Gly Leu Val Leu Ala Pro Phe Thr Ala Gly Thr 
    130                 135                 140


Ser Leu Ala Leu Thr Ala Ala Gly Val Gly Leu Gly Ala Ala Ser Ala 
145                 150                 155                 160


Val Thr Gly Ile Thr Thr Ser Ile Val Glu His Ser Tyr Thr Ser Ser 
                165                 170                 175


Ala Glu Ala Glu Ala Ser Arg Leu Thr Ala Thr Ser Ile Asp Arg Leu 
            180                 185                 190


Lys Val Phe Lys Glu Val Met Arg Asp Ile Thr Pro Asn Leu Leu Ser 
        195                 200                 205


Leu Leu Asn Asn Tyr Tyr Glu Ala Thr Gln Thr Ile Gly Ser Glu Ile 
    210                 215                 220


Arg Ala Ile Arg Gln Ala Arg Ala Arg Ala Arg Leu Pro Val Thr Thr 
225                 230                 235                 240


Trp Arg Ile Ser Ala Gly Ser Gly Gly Gln Ala Glu Arg Thr Ile Ala 
                245                 250                 255


Gly Thr Thr Arg Ala Val Ser Arg Gly Ala Arg Ile Leu Ser Ala Thr 
            260                 265                 270


Thr Ser Gly Ile Phe Leu Ala Leu Asp Val Val Asn Leu Val Tyr Glu 
        275                 280                 285


Ser Lys His Leu His Glu Gly Ala Lys Ser Ala Ser Ala Glu Glu Leu 
    290                 295                 300


Arg Arg Gln Ala Gln Glu Leu Glu Glu Asn Leu Met Glu Leu Thr Gln 
305                 310                 315                 320


Ile Tyr Gln Arg Leu Asn Pro Cys His Thr His 
                325                 330


<210>  1314
<211>  2118
<212>  DNA
<213>  Homo sapiens

<400>  1314
agcaggaggg tgggaccaag ggtgctgctg gaccaaggat gggactgggc caagggtggg     60

gctgggaagc atcctgtttt gcatgtttga tcaggagctg ctgccaagtt gtgactttca    120

ctttcccttt tgggttccag ggtatatctc agagcctgga gaacgtgtct ggttattatg    180

cagatgcacg gctggaggtg ggatccacac agctcagaac agctggatct tgctcacact    240

ctttcaagag aagcttcctt gaaaagaaac gctttactga agaggccacc aaatacttcc    300

gggagagagt cagcccagtg catctgcaaa tcctgctgac taacaatgaa gcctggaaga    360

gattcgtgac tgcggctgaa ttgcccaggg atgaggcaga tgctctctac gaagctctga    420

agaagcttag aacatatgca gctattgagg acgaatatgt gcagcagaaa gatgagcagt    480

ttagggaatg gtttttgaaa gagtttcccc aagtcaagag gaagatccag gagtccatag    540

aaaagcttcg tgcccttgca aatggtattg aagaggtcca cagaggctgc accatctcca    600

atgtggtgtc cagctccact ggcgctgcct ctggcatcat gtcccttgct ggtcttgttt    660

tggcaccatt tacagcaggg acgagtctgg cccttactgc agctggggta gggctgggag    720

cagcgtctgc tgtgactggg atcaccacca gcatcgtgga gcactcatac acatcatcag    780

cagaagctga agccagcagg ctgactgcaa ccagcattga ccgattgaag gtatttaagg    840

aagttatgcg tgacatcaca cccaacttac tttcccttct taataattat tacgaagcca    900

cacaaaccat tgggagtgaa atccgtgcca tcaggcaagc cagagccagg gcccgactcc    960

ctgtgaccac ctggcgaatc tcagctggaa gtggtggtca agcagagaga acgattgcag   1020

gcaccacccg ggcagtgagc agaggagccc ggatcctgag tgcgaccact tcaggcatct   1080

tccttgcact ggatgtggtc aaccttgtat acgagtcaaa gcacttgcat gagggggcaa   1140

agtctgcatc tgctgaggag ctgaggcggc aggctcagga gctggaggag aatctaatgg   1200

agctcactca gatctatcag cgtctgaatc catgccatac ccactgaccc cagaccagtg   1260

cagccagcag gggaggtgag ccatacacag gccacgacaa aatgcaggca ttttattagg   1320

gggataaaga gggcaaggta aagtttatgg agctgagtgt tagtgacttt ggcatttctg   1380

tagctgagca cagcagggga ggggttaatg cagatggcaa gtgcaccaag gagaaggcag   1440

gaatgctgga gcctggaata agggaggaga ggggactgga gagtgtgggg aataggaaga   1500

agaaatttcc tttagactaa cgaatatatt ggggggagga atagagggga ggtgtgcagg   1560

aaccagcaat gagaaggcca ggaaaagaaa gagctgaaaa tgcagaaagc cgaagagtta   1620

gaacttttgg atacagcaga agaaacagcg gctccactac cgacctgccc ccggttcgat   1680

gtccttccaa gaatgaagtc tttccctggt gatggtcccc tgccctgtct ttccagcatc   1740

cactctgtct tgtcctcctg gaagtgtatc tcagtcagcc agtggcttct tgatgatggc   1800

ggtggaggtg gtggttgtag tgtgatggat cccctttagg ttatttaggg gtatatgtcc   1860

cctgcttgaa ccctgaaggc caggtaatga gccatggcca ttgtccccag ctgaggacca   1920

ggtgtctcta aaaacccaaa catcctggag agtatgcgag aacctaccaa gaaaaacagt   1980

ctcattactc atatacagca ggcaaagaga cagaaaatta actgaaaagc agtttagaga   2040

ctgggggagg ccggatctct agagccatcc tgctgagtgc cctgtgtgta agtcctaata   2100

aactcaccta ctcaccaa                                                 2118


<210>  1315
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  1315

Met Gly Leu Gly Gln Gly Trp Gly Trp Glu Ala Ser Cys Phe Ala Cys 
1               5                   10                  15


Leu Ile Arg Ser Cys Cys Gln Val Val Thr Phe Thr Phe Pro Phe Gly 
            20                  25                  30


Phe Gln Gly Ile Ser Gln Ser Leu Glu Asn Val Ser Gly Tyr Tyr Ala 
        35                  40                  45


Asp Ala Arg Leu Glu Val Gly Ser Thr Gln Leu Arg Thr Ala Gly Ser 
    50                  55                  60


Cys Ser His Ser Phe Lys Arg Ser Phe Leu Glu Lys Lys Arg Phe Thr 
65                  70                  75                  80


Glu Glu Ala Thr Lys Tyr Phe Arg Glu Arg Val Ser Pro Val His Leu 
                85                  90                  95


Gln Ile Leu Leu Thr Asn Asn Glu Ala Trp Lys Arg Phe Val Thr Ala 
            100                 105                 110


Ala Glu Leu Pro Arg Asp Glu Ala Asp Ala Leu Tyr Glu Ala Leu Lys 
        115                 120                 125


Lys Leu Arg Thr Tyr Ala Ala Ile Glu Asp Glu Tyr Val Gln Gln Lys 
    130                 135                 140


Asp Glu Gln Phe Arg Glu Trp Phe Leu Lys Glu Phe Pro Gln Val Lys 
145                 150                 155                 160


Arg Lys Ile Gln Glu Ser Ile Glu Lys Leu Arg Ala Leu Ala Asn Gly 
                165                 170                 175


Ile Glu Glu Val His Arg Gly Cys Thr Ile Ser Asn Val Val Ser Ser 
            180                 185                 190


Ser Thr Gly Ala Ala Ser Gly Ile Met Ser Leu Ala Gly Leu Val Leu 
        195                 200                 205


Ala Pro Phe Thr Ala Gly Thr Ser Leu Ala Leu Thr Ala Ala Gly Val 
    210                 215                 220


Gly Leu Gly Ala Ala Ser Ala Val Thr Gly Ile Thr Thr Ser Ile Val 
225                 230                 235                 240


Glu His Ser Tyr Thr Ser Ser Ala Glu Ala Glu Ala Ser Arg Leu Thr 
                245                 250                 255


Ala Thr Ser Ile Asp Arg Leu Lys Val Phe Lys Glu Val Met Arg Asp 
            260                 265                 270


Ile Thr Pro Asn Leu Leu Ser Leu Leu Asn Asn Tyr Tyr Glu Ala Thr 
        275                 280                 285


Gln Thr Ile Gly Ser Glu Ile Arg Ala Ile Arg Gln Ala Arg Ala Arg 
    290                 295                 300


Ala Arg Leu Pro Val Thr Thr Trp Arg Ile Ser Ala Gly Ser Gly Gly 
305                 310                 315                 320


Gln Ala Glu Arg Thr Ile Ala Gly Thr Thr Arg Ala Val Ser Arg Gly 
                325                 330                 335


Ala Arg Ile Leu Ser Ala Thr Thr Ser Gly Ile Phe Leu Ala Leu Asp 
            340                 345                 350


Val Val Asn Leu Val Tyr Glu Ser Lys His Leu His Glu Gly Ala Lys 
        355                 360                 365


Ser Ala Ser Ala Glu Glu Leu Arg Arg Gln Ala Gln Glu Leu Glu Glu 
    370                 375                 380


Asn Leu Met Glu Leu Thr Gln Ile Tyr Gln Arg Leu Asn Pro Cys His 
385                 390                 395                 400


Thr His 



<210>  1316
<211>  3627
<212>  DNA
<213>  Homo sapiens

<400>  1316
actctgggga aaggagggta caaccacatg taaattttat tataatgatg gtataatgaa     60

cttggggtga cctgagggca tgtttttgtg ttactgggca tgtgcccctt taggagactt    120

ccacctgtgc cttactttct ctttctttgg gatgtgctgg ccacagactt taccaaaaac    180

tccatccatt aggatggcat taggacggtt ctggggctaa acttaggtgg gccaggggct    240

gtttcactgt cagcctttct actctctttt cttacccact cctagctgct aatgtctatt    300

taactaccta atatttcccc ctttagagaa aaaaagccaa atttttgggt agatcggtga    360

caattaatct ggctacttcc tgctgacaag aggcagtggt aataattggg ttctcttttt    420

tgctctcttg tagctggtag gttgggcaga gaaaagtggt ggccatccaa ggggcccacg    480

tagatatcag acatggttga gacctcgcgg taaccttgtg tagaatcatt tggagtttta    540

tggattctag gtgggaagaa acaaaacaac cttgtaaatc aaatgagcat cgtttgaaag    600

ctataagttg tataaagctg ttttaggacc aagaaagggg gctaaccagg aaaaccagga    660

ccagttgtta aatttccacc agtcaaagcc tcctgaaact ctgttttcca ttaacttgtt    720

ggccctgtct gtaatttttt taagttggtt tgcactttac ctgattggtt gatgaaaaca    780

gcaatgttta tcaagtgttg cacaagctcc cccttgattg gctgtgagca aattaaaagc    840

tcatcaattt cataagacta tgcttgctaa tgaagcaatt tgttctgaaa gggtattgac    900

ctggttagtt agattaataa tttgttgagt aatttttaag aagagtttct gggcagtaaa    960

aatggagtta aggaggtcct ccagttcccg tgccaatacc agccagaacg ccaattatag   1020

tcagtgctgt taaaactcct ctttcagttt taccagattg agcgtgtata gggaggggaa   1080

tgctatcgat aagagtgagt ttggggatga tgtaaactag ggccaaatcc ccgtttaatt   1140

agcagacaag cagagatatg ccttgtttct atacaaaaat gtgatttgtc atgttaagac   1200

aaatatcaac agtgatacta aagtagggtt tttccatgct gtgtaagtct gctttaatac   1260

cctcagaagt ggaagtcaag gctagttcat gtaatggggg aacacaggca gtacttgaca   1320

gaatgaaaga ggaatcaaaa gcccaattag aggaaggagt gatgggatcc caaccaatat   1380

tgtgaaatta tggggagctg cagttttttg caatgatttt gcccgaagtt gtgagactga   1440

aaccagaagt tgttatgttt aaaatgatat tctggtgtgg gtctggggaa aagggtagat   1500

ccagaatagc tggcttcttt ccacatagtg gttctgttgg ggggcttggg aaatgaataa   1560

aacacaaaga agaattagaa tatcaggtga aggtagcagg tgctcctggc agaagaaccc   1620

acataaggaa gtgtccagaa gccacacagg gtatatctca gagcctggag aacgtgtctg   1680

gttattatgc agatgcacgg ctggaggtgg gatccacaca gctcagaaca gctggatctt   1740

gctcacactc tttcaagaga agcttccttg aaaagaaacg ctttactgaa gaggccacca   1800

aatacttccg ggagagagtc agcccagtgc atctgcaaat cctgctgact aacaatgaag   1860

cctggaagag attcgtgact gcggctgaat tgcccaggga tgaggcagat gctctctacg   1920

aagctctgaa gaagcttaga acatatgcag ctattgagga cgaatatgtg cagcagaaag   1980

atgagcagtt tagggaatgg tttttgaaag agtttcccca agtcaagagg aagatccagg   2040

agtccataga aaagcttcgt gcccttgcaa atggtattga agaggtccac agaggctgca   2100

ccatctccaa tgtggtgtcc agctccactg gcgctgcctc tggcatcatg tcccttgctg   2160

gtcttgtttt ggcaccattt acagcaggga cgagtctggc ccttactgca gctggggtag   2220

ggctgggagc agcgtctgct gtgactggga tcaccaccag catcgtggag cactcataca   2280

catcatcagc agaagctgaa gccagcaggc tgactgcaac cagcattgac cgattgaagg   2340

tatttaagga agttatgcgt gacatcacac ccaacttact ttcccttctt aataattatt   2400

acgaagccac acaaaccatt gggagtgaaa tccgtgccat caggcaagcc agagccaggg   2460

cccgactccc tgtgaccacc tggcgaatct cagctggaag tggtggtcaa gcagagagaa   2520

cgattgcagg caccacccgg gcagtgagca gaggagcccg gatcctgagt gcgaccactt   2580

caggcatctt ccttgcactg gatgtggtca accttgtata cgagtcaaag cacttgcatg   2640

agggggcaaa gtctgcatct gctgaggagc tgaggcggca ggctcaggag ctggaggaga   2700

atctaatgga gctcactcag atctatcagc gtctgaatcc atgccatacc cactgacccc   2760

agaccagtgc agccagcagg ggaggtgagc catacacagg ccacgacaaa atgcaggcat   2820

tttattaggg ggataaagag ggcaaggtaa agtttatgga gctgagtgtt agtgactttg   2880

gcatttctgt agctgagcac agcaggggag gggttaatgc agatggcaag tgcaccaagg   2940

agaaggcagg aatgctggag cctggaataa gggaggagag gggactggag agtgtgggga   3000

ataggaagaa gaaatttcct ttagactaac gaatatattg gggggaggaa tagaggggag   3060

gtgtgcagga accagcaatg agaaggccag gaaaagaaag agctgaaaat gcagaaagcc   3120

gaagagttag aacttttgga tacagcagaa gaaacagcgg ctccactacc gacctgcccc   3180

cggttcgatg tccttccaag aatgaagtct ttccctggtg atggtcccct gccctgtctt   3240

tccagcatcc actctgtctt gtcctcctgg aagtgtatct cagtcagcca gtggcttctt   3300

gatgatggcg gtggaggtgg tggttgtagt gtgatggatc ccctttaggt tatttagggg   3360

tatatgtccc ctgcttgaac cctgaaggcc aggtaatgag ccatggccat tgtccccagc   3420

tgaggaccag gtgtctctaa aaacccaaac atcctggaga gtatgcgaga acctaccaag   3480

aaaaacagtc tcattactca tatacagcag gcaaagagac agaaaattaa ctgaaaagca   3540

gtttagagac tgggggaggc cggatctcta gagccatcct gctgagtgcc ctgtgtgtaa   3600

gtcctaataa actcacctac tcaccaa                                       3627


<210>  1317
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  1317

Met Ser Leu Ala Gly Leu Val Leu Ala Pro Phe Thr Ala Gly Thr Ser 
1               5                   10                  15


Leu Ala Leu Thr Ala Ala Gly Val Gly Leu Gly Ala Ala Ser Ala Val 
            20                  25                  30


Thr Gly Ile Thr Thr Ser Ile Val Glu His Ser Tyr Thr Ser Ser Ala 
        35                  40                  45


Glu Ala Glu Ala Ser Arg Leu Thr Ala Thr Ser Ile Asp Arg Leu Lys 
    50                  55                  60


Val Phe Lys Glu Val Met Arg Asp Ile Thr Pro Asn Leu Leu Ser Leu 
65                  70                  75                  80


Leu Asn Asn Tyr Tyr Glu Ala Thr Gln Thr Ile Gly Ser Glu Ile Arg 
                85                  90                  95


Ala Ile Arg Gln Ala Arg Ala Arg Ala Arg Leu Pro Val Thr Thr Trp 
            100                 105                 110


Arg Ile Ser Ala Gly Ser Gly Gly Gln Ala Glu Arg Thr Ile Ala Gly 
        115                 120                 125


Thr Thr Arg Ala Val Ser Arg Gly Ala Arg Ile Leu Ser Ala Thr Thr 
    130                 135                 140


Ser Gly Ile Phe Leu Ala Leu Asp Val Val Asn Leu Val Tyr Glu Ser 
145                 150                 155                 160


Lys His Leu His Glu Gly Ala Lys Ser Ala Ser Ala Glu Glu Leu Arg 
                165                 170                 175


Arg Gln Ala Gln Glu Leu Glu Glu Asn Leu Met Glu Leu Thr Gln Ile 
            180                 185                 190


Tyr Gln Arg Leu Asn Pro Cys His Thr His 
        195                 200


<210>  1318
<211>  3564
<212>  DNA
<213>  Homo sapiens

<400>  1318
actctgggga aaggagggta caaccacatg taaattttat tataatgatg gtataatgaa     60

cttggggtga cctgagggca tgtttttgtg ttactgggca tgtgcccctt taggagactt    120

ccacctgtgc cttactttct ctttctttgg gatgtgctgg ccacagactt taccaaaaac    180

tccatccatt aggatggcat taggacggtt ctggggctaa acttaggtgg gccaggggct    240

gtttcactgt cagcctttct actctctttt cttacccact cctagctgct aatgtctatt    300

taactaccta atatttcccc ctttagagaa aaaaagccaa atttttgggt agatcggtga    360

caattaatct ggctacttcc tgctgacaag aggcagtggt aataattggg ttctcttttt    420

tgctctcttg tagctggtag gttgggcaga gaaaagtggt ggccatccaa ggggcccacg    480

tagatatcag acatggttga gacctcgcgg taaccttgtg tagaatcatt tggagtttta    540

tggattctag gtgggaagaa acaaaacaac cttgtaaatc aaatgagcat cgtttgaaag    600

ctataagttg tataaagctg ttttaggacc aagaaagggg gctaaccagg aaaaccagga    660

ccagttgtta aatttccacc agtcaaagcc tcctgaaact ctgttttcca ttaacttgtt    720

ggccctgtct gtaatttttt taagttggtt tgcactttac ctgattggtt gatgaaaaca    780

gcaatgttta tcaagtgttg cacaagctcc cccttgattg gctgtgagca aattaaaagc    840

tcatcaattt cataagacta tgcttgctaa tgaagcaatt tgttctgaaa gggtattgac    900

ctggttagtt agattaataa tttgttgagt aatttttaag aagagtttct gggcagtaaa    960

aatggagtta aggaggtcct ccagttcccg tgccaatacc agccagaacg ccaattatag   1020

tcagtgctgt taaaactcct ctttcagttt taccagattg agcgtgtata gggaggggaa   1080

tgctatcgat aagagtgagt ttggggatga tgtaaactag ggccaaatcc ccgtttaatt   1140

agcagacaag cagagatatg ccttgtttct atacaaaaat gtgatttgtc atgttaagac   1200

aaatatcaac agtgatacta aagtagggtt tttccatgct gtgtaagtct gctttaatac   1260

cctcagaagt ggaagtcaag gctagttcat gtaatggggg aacacaggca gtacttgaca   1320

gaatgaaaga ggaatcaaaa gcccaattag aggaaggagt gatgggatcc caaccaatat   1380

tgtgaaatta tggggagctg cagttttttg caatgatttt gcccgaagtt gtgagactga   1440

aaccagaagt tgttatgttt aaaatgatat tctggtgtgg gtctggggaa aagggtagat   1500

ccagaatagc tggcttcttt ccacatagtg gttctgttgg ggggcttggg aaatgaataa   1560

aacacaaaga agaattagaa tatcagggta tatctcagag cctggagaac gtgtctggtt   1620

attatgcaga tgcacggctg gaggtgggat ccacacagct cagaacagct ggatcttgct   1680

cacactcttt caagagaagc ttccttgaaa agaaacgctt tactgaagag gccaccaaat   1740

acttccggga gagagtcagc ccagtgcatc tgcaaatcct gctgactaac aatgaagcct   1800

ggaagagatt cgtgactgcg gctgaattgc ccagggatga ggcagatgct ctctacgaag   1860

ctctgaagaa gcttagaaca tatgcagcta ttgaggacga atatgtgcag cagaaagatg   1920

agcagtttag ggaatggttt ttgaaagagt ttccccaagt caagaggaag atccaggagt   1980

ccatagaaaa gcttcgtgcc cttgcaaatg gtattgaaga ggtccacaga ggctgcacca   2040

tctccaatgt ggtgtccagc tccactggcg ctgcctctgg catcatgtcc cttgctggtc   2100

ttgttttggc accatttaca gcagggacga gtctggccct tactgcagct ggggtagggc   2160

tgggagcagc gtctgctgtg actgggatca ccaccagcat cgtggagcac tcatacacat   2220

catcagcaga agctgaagcc agcaggctga ctgcaaccag cattgaccga ttgaaggtat   2280

ttaaggaagt tatgcgtgac atcacaccca acttactttc ccttcttaat aattattacg   2340

aagccacaca aaccattggg agtgaaatcc gtgccatcag gcaagccaga gccagggccc   2400

gactccctgt gaccacctgg cgaatctcag ctggaagtgg tggtcaagca gagagaacga   2460

ttgcaggcac cacccgggca gtgagcagag gagcccggat cctgagtgcg accacttcag   2520

gcatcttcct tgcactggat gtggtcaacc ttgtatacga gtcaaagcac ttgcatgagg   2580

gggcaaagtc tgcatctgct gaggagctga ggcggcaggc tcaggagctg gaggagaatc   2640

taatggagct cactcagatc tatcagcgtc tgaatccatg ccatacccac tgaccccaga   2700

ccagtgcagc cagcagggga ggtgagccat acacaggcca cgacaaaatg caggcatttt   2760

attaggggga taaagagggc aaggtaaagt ttatggagct gagtgttagt gactttggca   2820

tttctgtagc tgagcacagc aggggagggg ttaatgcaga tggcaagtgc accaaggaga   2880

aggcaggaat gctggagcct ggaataaggg aggagagggg actggagagt gtggggaata   2940

ggaagaagaa atttccttta gactaacgaa tatattgggg ggaggaatag aggggaggtg   3000

tgcaggaacc agcaatgaga aggccaggaa aagaaagagc tgaaaatgca gaaagccgaa   3060

gagttagaac ttttggatac agcagaagaa acagcggctc cactaccgac ctgcccccgg   3120

ttcgatgtcc ttccaagaat gaagtctttc cctggtgatg gtcccctgcc ctgtctttcc   3180

agcatccact ctgtcttgtc ctcctggaag tgtatctcag tcagccagtg gcttcttgat   3240

gatggcggtg gaggtggtgg ttgtagtgtg atggatcccc tttaggttat ttaggggtat   3300

atgtcccctg cttgaaccct gaaggccagg taatgagcca tggccattgt ccccagctga   3360

ggaccaggtg tctctaaaaa cccaaacatc ctggagagta tgcgagaacc taccaagaaa   3420

aacagtctca ttactcatat acagcaggca aagagacaga aaattaactg aaaagcagtt   3480

tagagactgg gggaggccgg atctctagag ccatcctgct gagtgccctg tgtgtaagtc   3540

ctaataaact cacctactca ccaa                                          3564


<210>  1319
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  1319

Met Ser Leu Ala Gly Leu Val Leu Ala Pro Phe Thr Ala Gly Thr Ser 
1               5                   10                  15


Leu Ala Leu Thr Ala Ala Gly Val Gly Leu Gly Ala Ala Ser Ala Val 
            20                  25                  30


Thr Gly Ile Thr Thr Ser Ile Val Glu His Ser Tyr Thr Ser Ser Ala 
        35                  40                  45


Glu Ala Glu Ala Ser Arg Leu Thr Ala Thr Ser Ile Asp Arg Leu Lys 
    50                  55                  60


Val Phe Lys Glu Val Met Arg Asp Ile Thr Pro Asn Leu Leu Ser Leu 
65                  70                  75                  80


Leu Asn Asn Tyr Tyr Glu Ala Thr Gln Thr Ile Gly Ser Glu Ile Arg 
                85                  90                  95


Ala Ile Arg Gln Ala Arg Ala Arg Ala Arg Leu Pro Val Thr Thr Trp 
            100                 105                 110


Arg Ile Ser Ala Gly Ser Gly Gly Gln Ala Glu Arg Thr Ile Ala Gly 
        115                 120                 125


Thr Thr Arg Ala Val Ser Arg Gly Ala Arg Ile Leu Ser Ala Thr Thr 
    130                 135                 140


Ser Gly Ile Phe Leu Ala Leu Asp Val Val Asn Leu Val Tyr Glu Ser 
145                 150                 155                 160


Lys His Leu His Glu Gly Ala Lys Ser Ala Ser Ala Glu Glu Leu Arg 
                165                 170                 175


Arg Gln Ala Gln Glu Leu Glu Glu Asn Leu Met Glu Leu Thr Gln Ile 
            180                 185                 190


Tyr Gln Arg Leu Asn Pro Cys His Thr His 
        195                 200


<210>  1320
<211>  3373
<212>  DNA
<213>  Homo sapiens

<400>  1320
ggtggcaact tctcctcctg cggccgggag cggcctgcct gcctccctgc gcacccgcag     60

cctcccccgc tgcctcccta gggctcccct ccggccgcca gcgcccattt ttcattccct    120

agatagagat actttgcgcg cacacacata catacgcgcg caaaaaggaa aaaaaaaaaa    180

aaaagcccac cctccagcct cgctgcaaag agaaaaccgg agcagccgca gctcgcagct    240

cgcagctcgc agcccgcagc ccgcagagga cgcccagagc ggcgagcagg cgggcagacg    300

gaccgacgga ctcgcgccgc gtccacctgt cggccgggcc cagccgagcg cgcagcgggc    360

acgccgcgcg cgcggagcag ccgtgcccgc cgcccgggcc cgccgccagg gcgcacacgc    420

tcccgccccc ctacccggcc cgggcgggag tttgcacctc tccctgcccg ggtgctcgag    480

ctgccgttgc aaagccaact ttggaaaaag ttttttgggg gagacttggg ccttgaggtg    540

cccagctccg cgctttccga ttttgggggc ctttccagaa aatgttgcaa aaaagctaag    600

ccggcgggca gaggaaaacg cctgtagccg gcgagtgaag acgaaccatc gactgccgtg    660

ttccttttcc tcttggaggt tggagtcccc tgggcgcccc cacacggcta gacgcctcgg    720

ctggttcgcg acgcagcccc ccggccgtgg atgctgcact cgggctcggg atccgcccag    780

gtagccggcc tcggacccag gtcctgcgcc caggtcctcc cctgcccccc agcgacggag    840

ccggggccgg gggcggcggc gccgggggca tgcgggtgag ccgcggctgc agaggcctga    900

gcgcctgatc gccgcggacc tgagccgagc ccacccccct ccccagcccc ccaccctggc    960

cgcgggggcg gcgcgctcga tctacgcgtc cggggccccg cggggccggg cccggagtcg   1020

gcatgaatcg ctgctgggcg ctcttcctgt ctctctgctg ctacctgcgt ctggtcagcg   1080

ccgaggggga ccccattccc gaggagcttt atgagatgct gagtgaccac tcgatccgct   1140

cctttgatga tctccaacgc ctgctgcacg gagaccccgg agaggaagat ggggccgagt   1200

tggacctgaa catgacccgc tcccactctg gaggcgagct ggagagcttg gctcgtggaa   1260

gaaggagcct gggttccctg accattgctg agccggccat gatcgccgag tgcaagacgc   1320

gcaccgaggt gttcgagatc tcccggcgcc tcatagaccg caccaacgcc aacttcctgg   1380

tgtggccgcc ctgtgtggag gtgcagcgct gctccggctg ctgcaacaac cgcaacgtgc   1440

agtgccgccc cacccaggtg cagctgcgac ctgtccaggt gagaaagatc gagattgtgc   1500

ggaagaagcc aatctttaag aaggccacgg tgacgctgga agaccacctg gcatgcaagt   1560

gtgagacagt ggcagctgca cggcctgtga cccgaagccc ggggggttcc caggagcagc   1620

gagccaaaac gccccaaact cgggtgacca ttcggacggt gcgagtccgc cggcccccca   1680

agggcaagca ccggaaattc aagcacacgc atgacaagac ggcactgaag gagacccttg   1740

gagcctaggg gcatcggcag gagagtgtgt gggcagggtt atttaatatg gtatttgctg   1800

tattgccccc atggggtcct tggagtgata atattgtttc cctcgtccgt ctgtctcgat   1860

gcctgattcg gacggccaat ggtgcttccc ccacccctcc acgtgtccgt ccacccttcc   1920

atcagcgggt ctcctcccag cggcctccgg tcttgcccag cagctcaaag aagaaaaaga   1980

aggactgaac tccatcgcca tcttcttccc ttaactccaa gaacttggga taagagtgtg   2040

agagagactg atggggtcgc tctttggggg aaacgggttc cttcccctgc acctggcctg   2100

ggccacacct gagcgctgtg gactgtcctg aggagccctg aggacctctc agcatagcct   2160

gcctgatccc tgaacccctg gccagctctg aggggaggca cctccaggca ggccaggctg   2220

cctcggactc catggctaag accacagacg ggcacacaga ctggagaaaa cccctcccac   2280

ggtgcccaaa caccagtcac ctcgtctccc tggtgcctct gtgcacagtg gcttcttttc   2340

gttttcgttt tgaagacgtg gactcctctt ggtgggtgtg gccagcacac caagtggctg   2400

ggtgccctct caggtgggtt agagatggag tttgctgttg aggtggtgta gatggtgacc   2460

tgggtatccc ctgcctcctg ccaccccttc ctccccatac tccactctga ttcacctctt   2520

cctctggttc ctttcatctc tctacctcca ccctgcattt tcctcttgtc ctggcccttc   2580

agtctgctcc accaaggggc tcttgaaccc cttattaagg ccccagatga ccccagtcac   2640

tcctctctag ggcagaagac tagaggccag ggcagcaagg gacctgctca tcatattcca   2700

acccagccac gactgccatg taaggttgtg cagggtgtgt actgcacaag gacattgtat   2760

gcagggagca ctgttcacat catagataaa gctgatttgt atatttatta tgacaatttc   2820

tggcagatgt aggtaaagag gaaaaggatc cttttcctaa ttcacacaaa gactccttgt   2880

ggactggctg tgcccctgat gcagcctgtg gctggagtgg ccaaatagga gggagactgt   2940

ggtaggggca gggaggcaac actgctgtcc acatgacctc catttcccaa agtcctctgc   3000

tccagcaact gcccttccag gtgggtgtgg gacacctggg agaaggtctc caagggaggg   3060

tgcagccctc ttgcccgcac ccctccctgc ttgcacactt ccccatcttt gatccttctg   3120

agctccacct ctggtggctc ctcctaggaa accagctcgt gggctgggaa tgggggagag   3180

aagggaaaag atccccaaga ccccctgggg tgggatctga gctcccacct cccttcccac   3240

ctactgcact ttcccccttc ccgccttcca aaacctgctt ccttcagttt gtaaagtcgg   3300

tgattatatt tttgggggct ttccttttat tttttaaatg taaaatttat ttatattccg   3360

tatttaaagt tgt                                                      3373


<210>  1321
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  1321

Met Asn Arg Cys Trp Ala Leu Phe Leu Ser Leu Cys Cys Tyr Leu Arg 
1               5                   10                  15


Leu Val Ser Ala Glu Gly Asp Pro Ile Pro Glu Glu Leu Tyr Glu Met 
            20                  25                  30


Leu Ser Asp His Ser Ile Arg Ser Phe Asp Asp Leu Gln Arg Leu Leu 
        35                  40                  45


His Gly Asp Pro Gly Glu Glu Asp Gly Ala Glu Leu Asp Leu Asn Met 
    50                  55                  60


Thr Arg Ser His Ser Gly Gly Glu Leu Glu Ser Leu Ala Arg Gly Arg 
65                  70                  75                  80


Arg Ser Leu Gly Ser Leu Thr Ile Ala Glu Pro Ala Met Ile Ala Glu 
                85                  90                  95


Cys Lys Thr Arg Thr Glu Val Phe Glu Ile Ser Arg Arg Leu Ile Asp 
            100                 105                 110


Arg Thr Asn Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val Gln 
        115                 120                 125


Arg Cys Ser Gly Cys Cys Asn Asn Arg Asn Val Gln Cys Arg Pro Thr 
    130                 135                 140


Gln Val Gln Leu Arg Pro Val Gln Val Arg Lys Ile Glu Ile Val Arg 
145                 150                 155                 160


Lys Lys Pro Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His Leu 
                165                 170                 175


Ala Cys Lys Cys Glu Thr Val Ala Ala Ala Arg Pro Val Thr Arg Ser 
            180                 185                 190


Pro Gly Gly Ser Gln Glu Gln Arg Ala Lys Thr Pro Gln Thr Arg Val 
        195                 200                 205


Thr Ile Arg Thr Val Arg Val Arg Arg Pro Pro Lys Gly Lys His Arg 
    210                 215                 220


Lys Phe Lys His Thr His Asp Lys Thr Ala Leu Lys Glu Thr Leu Gly 
225                 230                 235                 240


Ala 



<210>  1322
<211>  2378
<212>  DNA
<213>  Homo sapiens

<400>  1322
gtgtgtgtgt gtgtgcgcgc gcatctgaga gagagagaga gagagagaga ctgactgagc     60

aggaatggtg agatgtttat catgggcctc ggggacccca ttcccgagga gctttatgag    120

atgctgagtg accactcgat ccgctccttt gatgatctcc aacgcctgct gcacggagac    180

cccggagagg aagatggggc cgagttggac ctgaacatga cccgctccca ctctggaggc    240

gagctggaga gcttggctcg tggaagaagg agcctgggtt ccctgaccat tgctgagccg    300

gccatgatcg ccgagtgcaa gacgcgcacc gaggtgttcg agatctcccg gcgcctcata    360

gaccgcacca acgccaactt cctggtgtgg ccgccctgtg tggaggtgca gcgctgctcc    420

ggctgctgca acaaccgcaa cgtgcagtgc cgccccaccc aggtgcagct gcgacctgtc    480

caggtgagaa agatcgagat tgtgcggaag aagccaatct ttaagaaggc cacggtgacg    540

ctggaagacc acctggcatg caagtgtgag acagtggcag ctgcacggcc tgtgacccga    600

agcccggggg gttcccagga gcagcgagcc aaaacgcccc aaactcgggt gaccattcgg    660

acggtgcgag tccgccggcc ccccaagggc aagcaccgga aattcaagca cacgcatgac    720

aagacggcac tgaaggagac ccttggagcc taggggcatc ggcaggagag tgtgtgggca    780

gggttattta atatggtatt tgctgtattg cccccatggg gtccttggag tgataatatt    840

gtttccctcg tccgtctgtc tcgatgcctg attcggacgg ccaatggtgc ttcccccacc    900

cctccacgtg tccgtccacc cttccatcag cgggtctcct cccagcggcc tccggtcttg    960

cccagcagct caaagaagaa aaagaaggac tgaactccat cgccatcttc ttcccttaac   1020

tccaagaact tgggataaga gtgtgagaga gactgatggg gtcgctcttt gggggaaacg   1080

ggttccttcc cctgcacctg gcctgggcca cacctgagcg ctgtggactg tcctgaggag   1140

ccctgaggac ctctcagcat agcctgcctg atccctgaac ccctggccag ctctgagggg   1200

aggcacctcc aggcaggcca ggctgcctcg gactccatgg ctaagaccac agacgggcac   1260

acagactgga gaaaacccct cccacggtgc ccaaacacca gtcacctcgt ctccctggtg   1320

cctctgtgca cagtggcttc ttttcgtttt cgttttgaag acgtggactc ctcttggtgg   1380

gtgtggccag cacaccaagt ggctgggtgc cctctcaggt gggttagaga tggagtttgc   1440

tgttgaggtg gtgtagatgg tgacctgggt atcccctgcc tcctgccacc ccttcctccc   1500

catactccac tctgattcac ctcttcctct ggttcctttc atctctctac ctccaccctg   1560

cattttcctc ttgtcctggc ccttcagtct gctccaccaa ggggctcttg aaccccttat   1620

taaggcccca gatgacccca gtcactcctc tctagggcag aagactagag gccagggcag   1680

caagggacct gctcatcata ttccaaccca gccacgactg ccatgtaagg ttgtgcaggg   1740

tgtgtactgc acaaggacat tgtatgcagg gagcactgtt cacatcatag ataaagctga   1800

tttgtatatt tattatgaca atttctggca gatgtaggta aagaggaaaa ggatcctttt   1860

cctaattcac acaaagactc cttgtggact ggctgtgccc ctgatgcagc ctgtggctgg   1920

agtggccaaa taggagggag actgtggtag gggcagggag gcaacactgc tgtccacatg   1980

acctccattt cccaaagtcc tctgctccag caactgccct tccaggtggg tgtgggacac   2040

ctgggagaag gtctccaagg gagggtgcag ccctcttgcc cgcacccctc cctgcttgca   2100

cacttcccca tctttgatcc ttctgagctc cacctctggt ggctcctcct aggaaaccag   2160

ctcgtgggct gggaatgggg gagagaaggg aaaagatccc caagaccccc tggggtggga   2220

tctgagctcc cacctccctt cccacctact gcactttccc ccttcccgcc ttccaaaacc   2280

tgcttccttc agtttgtaaa gtcggtgatt atatttttgg gggctttcct tttatttttt   2340

aaatgtaaaa tttatttata ttccgtattt aaagttgt                           2378


<210>  1323
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  1323

Met Phe Ile Met Gly Leu Gly Asp Pro Ile Pro Glu Glu Leu Tyr Glu 
1               5                   10                  15


Met Leu Ser Asp His Ser Ile Arg Ser Phe Asp Asp Leu Gln Arg Leu 
            20                  25                  30


Leu His Gly Asp Pro Gly Glu Glu Asp Gly Ala Glu Leu Asp Leu Asn 
        35                  40                  45


Met Thr Arg Ser His Ser Gly Gly Glu Leu Glu Ser Leu Ala Arg Gly 
    50                  55                  60


Arg Arg Ser Leu Gly Ser Leu Thr Ile Ala Glu Pro Ala Met Ile Ala 
65                  70                  75                  80


Glu Cys Lys Thr Arg Thr Glu Val Phe Glu Ile Ser Arg Arg Leu Ile 
                85                  90                  95


Asp Arg Thr Asn Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val 
            100                 105                 110


Gln Arg Cys Ser Gly Cys Cys Asn Asn Arg Asn Val Gln Cys Arg Pro 
        115                 120                 125


Thr Gln Val Gln Leu Arg Pro Val Gln Val Arg Lys Ile Glu Ile Val 
    130                 135                 140


Arg Lys Lys Pro Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His 
145                 150                 155                 160


Leu Ala Cys Lys Cys Glu Thr Val Ala Ala Ala Arg Pro Val Thr Arg 
                165                 170                 175


Ser Pro Gly Gly Ser Gln Glu Gln Arg Ala Lys Thr Pro Gln Thr Arg 
            180                 185                 190


Val Thr Ile Arg Thr Val Arg Val Arg Arg Pro Pro Lys Gly Lys His 
        195                 200                 205


Arg Lys Phe Lys His Thr His Asp Lys Thr Ala Leu Lys Glu Thr Leu 
    210                 215                 220


Gly Ala 
225


<210>  1324
<211>  1348
<212>  DNA
<213>  Homo sapiens

<400>  1324
ccagatttgg ctttatatag cggacccgta aggccgaccg gcctctaccg gcgggatttg     60

atggcgtgat gtctcacaga aagttctccg ctcccagaca tgggtccctc ggcttcctgc    120

ctcggaagcg cagcagcagg catcgtggga aggtgaagag cttccctaag gatgacccgt    180

ccaagccggt ccacctcaca gccttcctgg gatacaaggc tggcatgact cacatcgtgc    240

gggaagtcga caggccggga tccaaggtga acaagaagga ggtggtggag gctgtgacca    300

ttgtagagac accacccatg gtggttgtgg gcattgtggg ctacgtggaa acccctcgag    360

gcctccggac cttcaagact gtctttgctg agcacatcag tgatgaatgc aagaggcgtt    420

tctataagaa ttggcataaa tctaagaaga aggcctttac caagtactgc aagaaatggc    480

aggatgagga tggcaagaag cagctggaga aggacttcag cagcatgaag aagtactgcc    540

aagtcatccg tgtcattgcc cacacccaga tgcgcctgct tcctctgcgc cagaagaagg    600

cccacctgat ggagatccag gtgaacggag gcactgtggc cgagaagctg gactgggccc    660

gcgagaggct tgagcagcag gtacctgtga accaagtgtt tgggcaggat gagatgatcg    720

acgtcatcgg ggtgaccaag ggcaaaggct acaaaggggt caccagtcgt tggcacacca    780

agaagctgcc ccgcaagacc caccgaggcc tgcgcaaggt ggcctgtatt ggggcatggc    840

atcctgctcg tgtagccttc tctgtggcac gcgctgggca gaaaggctac catcaccgca    900

ctgagatcaa caagaagatt tataagattg gccagggcta ccttatcaag gacggcaagc    960

tgatcaagaa caatgcctcc actgactatg acctatctga caagagcatc aaccctctgg   1020

gtggctttgt ccactatggt gaagtgacca atgactttgt catgctgaaa ggctgtgtgg   1080

tgggaaccaa gaagcgggtg ctcaccctcc gcaagtcctt gctggtgcag acgaagcggc   1140

gggctctgga gaagattgac cttaagttca ttgacaccac ctccaagttt ggccatggcc   1200

gcttccagac catggaggag aagaaagcat tcatgggacc actgaagaaa gaccgaattg   1260

caaaggaaga aggagcttaa tgccaggaac agattttgca gttggtgggg tctcaataaa   1320

agttattttc cactgacaaa aaaaaaaa                                      1348


<210>  1325
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  1325

Met Ser His Arg Lys Phe Ser Ala Pro Arg His Gly Ser Leu Gly Phe 
1               5                   10                  15


Leu Pro Arg Lys Arg Ser Ser Arg His Arg Gly Lys Val Lys Ser Phe 
            20                  25                  30


Pro Lys Asp Asp Pro Ser Lys Pro Val His Leu Thr Ala Phe Leu Gly 
        35                  40                  45


Tyr Lys Ala Gly Met Thr His Ile Val Arg Glu Val Asp Arg Pro Gly 
    50                  55                  60


Ser Lys Val Asn Lys Lys Glu Val Val Glu Ala Val Thr Ile Val Glu 
65                  70                  75                  80


Thr Pro Pro Met Val Val Val Gly Ile Val Gly Tyr Val Glu Thr Pro 
                85                  90                  95


Arg Gly Leu Arg Thr Phe Lys Thr Val Phe Ala Glu His Ile Ser Asp 
            100                 105                 110


Glu Cys Lys Arg Arg Phe Tyr Lys Asn Trp His Lys Ser Lys Lys Lys 
        115                 120                 125


Ala Phe Thr Lys Tyr Cys Lys Lys Trp Gln Asp Glu Asp Gly Lys Lys 
    130                 135                 140


Gln Leu Glu Lys Asp Phe Ser Ser Met Lys Lys Tyr Cys Gln Val Ile 
145                 150                 155                 160


Arg Val Ile Ala His Thr Gln Met Arg Leu Leu Pro Leu Arg Gln Lys 
                165                 170                 175


Lys Ala His Leu Met Glu Ile Gln Val Asn Gly Gly Thr Val Ala Glu 
            180                 185                 190


Lys Leu Asp Trp Ala Arg Glu Arg Leu Glu Gln Gln Val Pro Val Asn 
        195                 200                 205


Gln Val Phe Gly Gln Asp Glu Met Ile Asp Val Ile Gly Val Thr Lys 
    210                 215                 220


Gly Lys Gly Tyr Lys Gly Val Thr Ser Arg Trp His Thr Lys Lys Leu 
225                 230                 235                 240


Pro Arg Lys Thr His Arg Gly Leu Arg Lys Val Ala Cys Ile Gly Ala 
                245                 250                 255


Trp His Pro Ala Arg Val Ala Phe Ser Val Ala Arg Ala Gly Gln Lys 
            260                 265                 270


Gly Tyr His His Arg Thr Glu Ile Asn Lys Lys Ile Tyr Lys Ile Gly 
        275                 280                 285


Gln Gly Tyr Leu Ile Lys Asp Gly Lys Leu Ile Lys Asn Asn Ala Ser 
    290                 295                 300


Thr Asp Tyr Asp Leu Ser Asp Lys Ser Ile Asn Pro Leu Gly Gly Phe 
305                 310                 315                 320


Val His Tyr Gly Glu Val Thr Asn Asp Phe Val Met Leu Lys Gly Cys 
                325                 330                 335


Val Val Gly Thr Lys Lys Arg Val Leu Thr Leu Arg Lys Ser Leu Leu 
            340                 345                 350


Val Gln Thr Lys Arg Arg Ala Leu Glu Lys Ile Asp Leu Lys Phe Ile 
        355                 360                 365


Asp Thr Thr Ser Lys Phe Gly His Gly Arg Phe Gln Thr Met Glu Glu 
    370                 375                 380


Lys Lys Ala Phe Met Gly Pro Leu Lys Lys Asp Arg Ile Ala Lys Glu 
385                 390                 395                 400


Glu Gly Ala 



<210>  1326
<211>  1201
<212>  DNA
<213>  Homo sapiens

<400>  1326
ccagatttgg ctttatatag cggacccgta aggccgaccg gcctctaccg gcgggatttg     60

atggcgtgat gtctcacaga aagttctccg ctcccagaca tgggtccctc ggcttcctgc    120

ctcggaagcg cagcagcagg catcgtggga aggtgaagag cttccctaag gatgacccgt    180

ccaagccggt ccacctcaca gccttcctgg gatacaaggc tggcatgact cacatcgtgc    240

gggaagtcga caggccggga tccaaggtga acaagaagga ggtggtggag gctgtgacca    300

ttgtagagac accacccatg gtggttgtgg gcattgtggg ctacgtggaa acccctcgag    360

gcctccggac cttcaagact gtctttgctg agcacatcag tgatgaatgc aagaggcgtt    420

tctataagaa ttggcataaa tctaagaaga aggcccacct gatggagatc caggtgaacg    480

gaggcactgt ggccgagaag ctggactggg cccgcgagag gcttgagcag caggtacctg    540

tgaaccaagt gtttgggcag gatgagatga tcgacgtcat cggggtgacc aagggcaaag    600

gctacaaagg ggtcaccagt cgttggcaca ccaagaagct gccccgcaag acccaccgag    660

gcctgcgcaa ggtggcctgt attggggcat ggcatcctgc tcgtgtagcc ttctctgtgg    720

cacgcgctgg gcagaaaggc taccatcacc gcactgagat caacaagaag atttataaga    780

ttggccaggg ctaccttatc aaggacggca agctgatcaa gaacaatgcc tccactgact    840

atgacctatc tgacaagagc atcaaccctc tgggtggctt tgtccactat ggtgaagtga    900

ccaatgactt tgtcatgctg aaaggctgtg tggtgggaac caagaagcgg gtgctcaccc    960

tccgcaagtc cttgctggtg cagacgaagc ggcgggctct ggagaagatt gaccttaagt   1020

tcattgacac cacctccaag tttggccatg gccgcttcca gaccatggag gagaagaaag   1080

cattcatggg accactgaag aaagaccgaa ttgcaaagga agaaggagct taatgccagg   1140

aacagatttt gcagttggtg gggtctcaat aaaagttatt ttccactgac aaaaaaaaaa   1200

a                                                                   1201


<210>  1327
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  1327

Met Ser His Arg Lys Phe Ser Ala Pro Arg His Gly Ser Leu Gly Phe 
1               5                   10                  15


Leu Pro Arg Lys Arg Ser Ser Arg His Arg Gly Lys Val Lys Ser Phe 
            20                  25                  30


Pro Lys Asp Asp Pro Ser Lys Pro Val His Leu Thr Ala Phe Leu Gly 
        35                  40                  45


Tyr Lys Ala Gly Met Thr His Ile Val Arg Glu Val Asp Arg Pro Gly 
    50                  55                  60


Ser Lys Val Asn Lys Lys Glu Val Val Glu Ala Val Thr Ile Val Glu 
65                  70                  75                  80


Thr Pro Pro Met Val Val Val Gly Ile Val Gly Tyr Val Glu Thr Pro 
                85                  90                  95


Arg Gly Leu Arg Thr Phe Lys Thr Val Phe Ala Glu His Ile Ser Asp 
            100                 105                 110


Glu Cys Lys Arg Arg Phe Tyr Lys Asn Trp His Lys Ser Lys Lys Lys 
        115                 120                 125


Ala His Leu Met Glu Ile Gln Val Asn Gly Gly Thr Val Ala Glu Lys 
    130                 135                 140


Leu Asp Trp Ala Arg Glu Arg Leu Glu Gln Gln Val Pro Val Asn Gln 
145                 150                 155                 160


Val Phe Gly Gln Asp Glu Met Ile Asp Val Ile Gly Val Thr Lys Gly 
                165                 170                 175


Lys Gly Tyr Lys Gly Val Thr Ser Arg Trp His Thr Lys Lys Leu Pro 
            180                 185                 190


Arg Lys Thr His Arg Gly Leu Arg Lys Val Ala Cys Ile Gly Ala Trp 
        195                 200                 205


His Pro Ala Arg Val Ala Phe Ser Val Ala Arg Ala Gly Gln Lys Gly 
    210                 215                 220


Tyr His His Arg Thr Glu Ile Asn Lys Lys Ile Tyr Lys Ile Gly Gln 
225                 230                 235                 240


Gly Tyr Leu Ile Lys Asp Gly Lys Leu Ile Lys Asn Asn Ala Ser Thr 
                245                 250                 255


Asp Tyr Asp Leu Ser Asp Lys Ser Ile Asn Pro Leu Gly Gly Phe Val 
            260                 265                 270


His Tyr Gly Glu Val Thr Asn Asp Phe Val Met Leu Lys Gly Cys Val 
        275                 280                 285


Val Gly Thr Lys Lys Arg Val Leu Thr Leu Arg Lys Ser Leu Leu Val 
    290                 295                 300


Gln Thr Lys Arg Arg Ala Leu Glu Lys Ile Asp Leu Lys Phe Ile Asp 
305                 310                 315                 320


Thr Thr Ser Lys Phe Gly His Gly Arg Phe Gln Thr Met Glu Glu Lys 
                325                 330                 335


Lys Ala Phe Met Gly Pro Leu Lys Lys Asp Arg Ile Ala Lys Glu Glu 
            340                 345                 350


Gly Ala 



<210>  1328
<211>  93
<212>  DNA
<213>  Homo sapiens

<400>  1328
gctgttcagt gatgaggcct ggaatgtgcg ctgggcacag cgcccgagac agactgcgga     60

accgttcctt gttgccttcc ttctgagaac agc                                  93


<210>  1329
<211>  95
<212>  DNA
<213>  Homo sapiens

<400>  1329
gctgttcgtt gatgaggctc agagtgagcg ctgggtacag cgcccgaatc ggacagtgta     60

gaaccattct ctactgcctt ccttctgaga acagc                                95


<210>  1330
<211>  55
<212>  DNA
<213>  Homo sapiens

<400>  1330
ggggtgatga aggcctgcac ctggtcccct ccccaactct gctctgctcc tgaag          55


<210>  1331
<211>  62
<212>  DNA
<213>  Homo sapiens

<400>  1331
cacagatgat gaacttattg acgggcggac agaaactgtg tgctgattgt cacgttctga     60

tt                                                                    62


<210>  1332
<211>  4068
<212>  DNA
<213>  Homo sapiens

<400>  1332
ggcagagcgc ggcgcggggc cggcggcgaa ggtccggggt ggaatcgacg tcgctgcggc     60

tgccgacgac ccacacccgg ccggccgcct ccgcagaccc accttggccg cgcggcaggg    120

ggcgcgcaga gccccgaggg agcgagtccc cgcgcgtggc agctcggcgg cttctccctt    180

cgggaggtcc ggctcccggc tctccggacc cgcctggcgt cctcgcctgc ggcggggcgg    240

acgacagcgg cgcccaggaa tggcttcggc gggcagcggc atggaggagg tgcgcgtgtc    300

ggtgctgacc cccttgaagc tggtcgggct ggtgtgcatc ttcctggcgc tgtgtctgga    360

cctgggggcg gtgctgagcc cggcctgggt cacagctgac caccagtact acctgtcgtt    420

gtgggagtcc tgccgcaaac ccgccagctt ggacatctgg cactgcgagt ccacgctcag    480

cagcgattgg cagattgcta ctctggcttt actcctgggc ggcgctgcca tcattctcat    540

tgcattcctg gtgggtttga tttctatctg cgtgggatct cgaaggcgtt tctatagacc    600

tgttgcggtc atgctttttg cagcagttgt tttacaggtt tgcagcctgg tcctttaccc    660

aatcaagttc attgaaactg tgagcttgaa aatttaccat gagttcaact ggggttatgg    720

cctggcctgg ggtgcaacta tattttcgtt tgggggtgcc atcctttatt gcctgaaccc    780

taagaactat gaagactact actagaacca atagtctcaa agtaaaaaca accaccacca    840

tccaacaaaa ggattacgtc tgcatctttt ctaacttact attttctaaa acacttgtgg    900

agcatcaagc agtttgctca gttgatttaa tcttttttgc cttttggctg tcaacatcat    960

aaccagcttt tacatccatt ttagaaatct gcacaaatta agagagctga ttagacatag   1020

gcaaatgctg caaacttcca atatgttcat atcgtttttc ttgacaaatg aagggtctat   1080

atgacagcaa ccattgtgag aaactagttg gaatgagatt tgcctcaatc tcctattgcc   1140

tgcaggggag cagttggcat aagcaacatt tagaagttcc tttgcgctga caaggattcc   1200

actgttagag cccttaccgc ctgcttatcc tacccaatga ctacattggc tgttggttat   1260

ttgcttgagt gagcccttga aaaatgaact gcccttcagc atctaatggg agttgtgaat   1320

gtaactggtt aatgatacac attccacctt caggaacact ctttttaatg ggaggttatg   1380

ctttggcaat cagcgtctcc ctgggaagag agtcaagact tggagacatg tgcttctcat   1440

tatgtggtta gaaattggtg cctcagccct atctagactg gggaaaaatt gaggatctct   1500

gtttttcctg gggcaaacag aaagaaatct gcatgagttg cttttgtacc ctttaaatca   1560

tttgccaaac attgcagcaa acaagtgtgc gtatgtaaca agcttcactg tttttataga   1620

aggtgaacca ttagtataaa tggtaataag ttgttcccta accctccaca tacatttgcc   1680

tatcacacgt aaaattaata tttactctag tgaagtggtt tgagcactaa ccttgtacac   1740

attgttaaga ggcttagatt ggtattcata cttatttacc atacaaaagt atggtacctt   1800

aaagcttttg ctctatgttc tttactgttt cactggaaag tgtcaataga gttgcctaag   1860

aataaaaatt gaaatggtgt taatctgaaa attaatgatt ctctgtaagc actgtagttg   1920

aaaagagagt agcaattagg atgatcattt tgtgtaaaat tcattaaaat agaaggctgc   1980

tattttttgc aagtatttta aatgtcttca tttttttaag aaaggaatag cgatagattt   2040

atataaatat ctaaatgtct cagtagagga gtagaattca tctggttatc acctggtcct   2100

ctgaagttaa ctgatgggct aaccgatttg tgcacacact taggatggat ttatgttaag   2160

ggaattactt actgactgtt caatggaagg aagtattaat aatagggaat aagtttgcaa   2220

ctaatctcat gctgcaaact tgtgttaatt ctgtttaata tacaaatttg gatagcttaa   2280

ttataaacat atttttatat caaatataca gttctaatat aaaagttata aataattatt   2340

tttgttaaca aagacactaa aacagtatgt tctggttttg gccctcttgc agaaagaagc   2400

attagaaaaa ttactttaaa agtagctata tgttactgta ttgcaaaatc tgttaagagc   2460

aggaccacat cgatagtatt taataatttg ttttacctcc caaaacacag ttcttctttc   2520

agcttgtctt aagaatggtt gccaaaaaca acagccaaaa aaaaaaaacc tattttatta   2580

tccaaatgct agaaaacaca catgaatttt ctataaaatc acgaatatga agtaccaggt   2640

ttagtcttac tttagcaatg atagacaaaa gcgaataaat acatcacaga cagaaacctt   2700

tataaaaata tatgattcta taaagaatca ttagaaatta tgagtggaaa ttctccagaa   2760

agatagtatt atagagtctt ttgaagcaat tttttgagaa atagtaaaat ctggggcaga   2820

gtgtcttgca gttaattgca tattgtcaga gcagcatgag aaatatgata tttggatagg   2880

gatttcagca actaaacatt ctctgttctg agatctcttt attcctgaat aatgaaagaa   2940

tagtactttg gtgctgacac caatgaggca cttctcttgg tcctagtaga ggatgcagtg   3000

tactgttaaa ccaatatcat cacatctcga gtcttatcaa gttttcattc tctgtcaata   3060

tgacaagctc aaagtgacag aatatgttat aggttgaagc acacatattt gcagtttact   3120

gaaaagtaga tttcttatgt gacttttttc ccttctcagc aaagagccct acactagatt   3180

tctaccatca ctaatatttg gaagtatttc attactaaca atctcagtac aacatgaaaa   3240

ttgttgcttc tcatctaaaa tacaattttg tctatcagaa taaacacaag tgaaattttc   3300

acctacatta acattatgtc tttgcagctt taggtttgtt agatgtgttc ttaagcataa   3360

tttttagcca caaacccatt gttagataga tatctatgga tatagatcta catctataga   3420

tatagatata cacacatata tatactcaca cacatatagc ataaaatact cagcagggct   3480

agttattccg atttcttgca caattattta gctttttgta agttcaacat gtaaatttta   3540

aagacataaa tatagagaga cttatgtgtt tgaatataaa tgatatatat ggattagcat   3600

gtacctgtat attattaaac atgcaatgaa ctgactggta agtgacgtct aattgtatgg   3660

ctagcaatgt aatttattca gactgtattt ttgtacagag cagtgcactc taacctatgc   3720

ctctgtgtcc tctttaatgc ctaaagctgt gcctagaaat ttcatctgtc ttaaaagtaa   3780

aatatacttc atgctgttta tgctattagt ttctgtactg ctattctata tttattattt   3840

ttaaatatat gacatgttta ctacttaaac atgaattcat ggtatcctgg ttattttttt   3900

taagtcatct gggggaaaac ctgtttatca ctccagtgat tttgagtttg cagtttcaca   3960

atcagttctt catttcatga tttttgtagt tgacatgaag tcatctatgt ggaaaaaaat   4020

aaaaataaaa gtgatttcac ggatgtggtt tgaaaaaaaa aaaaaaaa                4068


<210>  1333
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  1333

Met Ala Ser Ala Gly Ser Gly Met Glu Glu Val Arg Val Ser Val Leu 
1               5                   10                  15


Thr Pro Leu Lys Leu Val Gly Leu Val Cys Ile Phe Leu Ala Leu Cys 
            20                  25                  30


Leu Asp Leu Gly Ala Val Leu Ser Pro Ala Trp Val Thr Ala Asp His 
        35                  40                  45


Gln Tyr Tyr Leu Ser Leu Trp Glu Ser Cys Arg Lys Pro Ala Ser Leu 
    50                  55                  60


Asp Ile Trp His Cys Glu Ser Thr Leu Ser Ser Asp Trp Gln Ile Ala 
65                  70                  75                  80


Thr Leu Ala Leu Leu Leu Gly Gly Ala Ala Ile Ile Leu Ile Ala Phe 
                85                  90                  95


Leu Val Gly Leu Ile Ser Ile Cys Val Gly Ser Arg Arg Arg Phe Tyr 
            100                 105                 110


Arg Pro Val Ala Val Met Leu Phe Ala Ala Val Val Leu Gln Val Cys 
        115                 120                 125


Ser Leu Val Leu Tyr Pro Ile Lys Phe Ile Glu Thr Val Ser Leu Lys 
    130                 135                 140


Ile Tyr His Glu Phe Asn Trp Gly Tyr Gly Leu Ala Trp Gly Ala Thr 
145                 150                 155                 160


Ile Phe Ser Phe Gly Gly Ala Ile Leu Tyr Cys Leu Asn Pro Lys Asn 
                165                 170                 175


Tyr Glu Asp Tyr Tyr 
            180


<210>  1334
<211>  1813
<212>  DNA
<213>  Homo sapiens

<400>  1334
cccctcccgc gcgcccgccc gccgcctgcc gccgccgccg ccgccgccgg agctctgtag     60

tatggcatcg aggagaatgg agaccaaacc tgtgataacc tgtctcaaaa ccctcctcat    120

catctactcc ttcgtcttct ggatcactgg ggtgatcctg ctggctgttg gagtctgggg    180

caaacttact ctgggcacct atatctccct tattgccgag aactccacaa atgctcccta    240

tgtgctcatc ggaactggca ccactattgt tgtctttggc ctgtttggat gctttgctac    300

atgtcgtggt agcccatgga tgctgaaact gtatgccatg tttctgtccc tggtgttcct    360

ggctgagctc gtagctggca tttcagggtt tgtgtttcgt catgagatca aggacacctt    420

cctgaggact tacacggacg ctatgcagac ttacaatggc aatgatgaga ggagccgggc    480

agtggaccat gtgcagcgca gcctgagctg ctgtggtgtg cagaactaca ccaactggag    540

caccagcccc tacttcctgg agcatggcat cccccccagc tgctgcatga acgaaactga    600

ttgtaatccc caggatctac acaatctgac tgtggccgcc accaaagtta accagaaggg    660

ttgttatgat ctggtaacta gtttcatgga gactaacatg ggaatcatcg ctggagtggc    720

gtttggaatc gcattctccc agttaattgg catgctgctg gcctgctgtc tgtcccggtt    780

catcacggcc aatcagtatg agatggtgta aggagaagtc tttcaagaat gacggaataa    840

gagacctgtt ttaaaaagga actgcagcaa tctttgaaag acttccaaag aatgttagag    900

cacagtacat aatacacttg ccctgctccc tctacccctt accccacaac gtgcaactga    960

cactcccacc cagtctctgc tccacctttc agcccacgtc acgtgtagtg tccattttgt   1020

gaagccctgt tgtgccacag agtgtagcca ggtccccctg cagctagtcc tagtgaacct   1080

caccccgagg ccctgcatgg gccagcccct ccatctgtac ttggtccaac tgcaactcat   1140

catcggtgac tggttatcac accatcgctg gcccctttgg gccctgcatg tagtgtggga   1200

ggctcctgtt agctcctcac tgtggtaaat gccacacacc tttaagtaga taagcagacg   1260

atagttatct gttcttttga cttaatctca tttggtttga ttttccctct actaaggctt   1320

tcctaccttc ttcaggctgc ctaagacatg taacgaaaca cttcaataat tgtccatgag   1380

gagaaaaaaa gcatgtgtca tgcatgaagg aaactgaact tgaggtggcc tccttgcttg   1440

ttacatacct gggtatgtgt aggcagttta gtgcatcttt gcctctcagt tgaaacctgt   1500

ataaccctgt tacaaagctg tgttgttgct tcttgtgaag gccatgatat tttgtttttc   1560

cccaattaat tgctattgtg ttattttact acttctctct gtattttttc ttgcattgac   1620

attatagaca ttgaggacct catccaaaca atttaaaaat gagtgtgaag ggggaacaag   1680

tcaaaatatt tttaaaagat cttcaaaaat aatgcctctg tctagcatgc caacaagaat   1740

gcattgatat tgtgaacatt tgtgatatat gtattaataa atagagcaat tacaagcaaa   1800

aaaaaaaaaa aaa                                                      1813


<210>  1335
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  1335

Met Ala Ser Arg Arg Met Glu Thr Lys Pro Val Ile Thr Cys Leu Lys 
1               5                   10                  15


Thr Leu Leu Ile Ile Tyr Ser Phe Val Phe Trp Ile Thr Gly Val Ile 
            20                  25                  30


Leu Leu Ala Val Gly Val Trp Gly Lys Leu Thr Leu Gly Thr Tyr Ile 
        35                  40                  45


Ser Leu Ile Ala Glu Asn Ser Thr Asn Ala Pro Tyr Val Leu Ile Gly 
    50                  55                  60


Thr Gly Thr Thr Ile Val Val Phe Gly Leu Phe Gly Cys Phe Ala Thr 
65                  70                  75                  80


Cys Arg Gly Ser Pro Trp Met Leu Lys Leu Tyr Ala Met Phe Leu Ser 
                85                  90                  95


Leu Val Phe Leu Ala Glu Leu Val Ala Gly Ile Ser Gly Phe Val Phe 
            100                 105                 110


Arg His Glu Ile Lys Asp Thr Phe Leu Arg Thr Tyr Thr Asp Ala Met 
        115                 120                 125


Gln Thr Tyr Asn Gly Asn Asp Glu Arg Ser Arg Ala Val Asp His Val 
    130                 135                 140


Gln Arg Ser Leu Ser Cys Cys Gly Val Gln Asn Tyr Thr Asn Trp Ser 
145                 150                 155                 160


Thr Ser Pro Tyr Phe Leu Glu His Gly Ile Pro Pro Ser Cys Cys Met 
                165                 170                 175


Asn Glu Thr Asp Cys Asn Pro Gln Asp Leu His Asn Leu Thr Val Ala 
            180                 185                 190


Ala Thr Lys Val Asn Gln Lys Gly Cys Tyr Asp Leu Val Thr Ser Phe 
        195                 200                 205


Met Glu Thr Asn Met Gly Ile Ile Ala Gly Val Ala Phe Gly Ile Ala 
    210                 215                 220


Phe Ser Gln Leu Ile Gly Met Leu Leu Ala Cys Cys Leu Ser Arg Phe 
225                 230                 235                 240


Ile Thr Ala Asn Gln Tyr Glu Met Val 
                245


<210>  1336
<211>  2454
<212>  DNA
<213>  Homo sapiens

<400>  1336
ggctcactct gcaaccaagg cacgtgcatt ctggtcatcc cacgcgggga gcgcgcgcaa     60

ggcccgccca gcccccacat gccagcccca ccctccagtc ggtccggacg ccgacgcctt    120

tttgaccctc gctgtgcccg gccctcctca tctggcctgc ccagggcttg gtgctggcgg    180

ggtccagctg ctccaatccc tcctcctctg ctctgccctg ccctgccctg gcctgccccg    240

gcgccctccc tcagcccggg tatcaggcga gaggcggagc tggcccggcg cgccccgccc    300

ccgctgtaga aagggccggg cgagtgttac tcgcggtcat cccggcctgg gccttttatc    360

tcggtgctgc cgggggaggc gggaggagga gacaccaggg gtggccctga gcgccggcga    420

cacctttcct ggactataaa ttgagcacct gggatgggta gggggccaac gcagtcaccg    480

ccgtccgcag tcacagtcca gccactgacc gcagcagcgc ccttgcgtag cagccgcttg    540

cagcgagaac actgaattgc caacgagcag gagagtctca aggcgcaaga ggaggccagg    600

gctcgaccca cagagcaccc tcagccatcg cgagtttccg ggcgccaaag ccaggagaag    660

ccgcccatcc cgcagggccg gtctgccagc gagacgagag ttggcgaggg cggaggagtg    720

ccgggaatcc cgccacaccg gctatagcca ggcccccagc gcgggccttg gagagcgcgt    780

gaaggcgggc atccccttga cccggccgac catccccgtg cccctgcgtc cctgcgctcc    840

aacgtccgcg cggccaccat gatgcaaatc tgcgacacct acaaccagaa gcactcgctc    900

tttaacgcca tgaatcgctt cattggcgcc gtgaacaaca tggaccagac ggtgatggtg    960

cccagcttgc tgcgcgacgt gcccctggct gaccccgggt tagacaacga tgttggcgtg   1020

gaggtaggcg gcagtggcgg ctgcctggag gagcgcacgc ccccagtccc cgactcggga   1080

agcgccaatg gcagcttttt cgcgccctct cgggacatgt acagccacta cgtgcttctc   1140

aagtccatcc gcaacgacat cgagtggggg gtcctgcacc agccgcctcc accggctggg   1200

agcgaggagg gcagtgcctg gaagtccaag gacatcctgg tggacctggg ccacttggag   1260

ggtgcggacg ccggcgaaga agacctggaa cagcagttcc actaccacct gcgcgggctg   1320

cacactgtgc tctcgaaact cacgcgcaaa gccaacatcc tcactaacag atacaagcag   1380

gagatcggct tcggcaattg gggccactga ggcgtggcgc ccgtggctgc ccagcacctt   1440

cttcgaccca tctcaccctc tctcattcct caaagctttt tttttttttc ctggctgggg   1500

ggcgggaagg gcagactgca aactgggggg ctgcgtacgt gcaggaggcg cggtggggct   1560

gcgtggagga gggggccacg tgtgagagag aagaaaatgg tggccggaga tgggagggcc   1620

caaggaacct cctgggaggg ggcctgcatt ctatgttggt gggaatggga ctgggctgac   1680

gccctgcatt cagcctgtgc ctttcctggg gtttcttttc tgttcttttc ggaggagagg   1740

gcccgagaag gggccatacc agggcgcggc gctgggttgc cacacttggg aaagcagccc   1800

ggagctgggt gctggggaag gcggggcgcg tagcctcccg ccgccctgcg gttgggccgg   1860

tggaggccca ggcgttgcta ggattgcatc agttttcctg tttgcactat ttctttttgt   1920

aacattggcc ctgtgtgaag tatttcgaat ctcctccttg ctctgaaact tcagcgattc   1980

cattgtgata agcgcacaaa cagcactgtc tgtcggtaat cggtactact ttattaatga   2040

ttttctgtta cactgtatag tagtcctatg gcacccccac cccatccctt tcgtgccact   2100

cccgtcccca cccccacccc agtgtgtata agctggcatt tcgccagctt gtacgtagct   2160

tgccactcag tgaaaataat aacattatta tgagaaagtg gacttaaccg aaatggaacc   2220

aactgacatt ctatcgtgtt gtacatagaa tgatgaaggg ttccactgtt gttgtatgtc   2280

ttaaatttat ttaaaacttt ttttaatcca gatgtagact atattctaaa aaataaaaaa   2340

gcaaatgtgt caactaaatt ggacaagcgt ctggtcctca ttaatctgcc aatgaatggt   2400

ttcgtcatta aataaaaatc aatttaattg atttactagc aaaaaaaaaa aaaa         2454


<210>  1337
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  1337

Met Met Gln Ile Cys Asp Thr Tyr Asn Gln Lys His Ser Leu Phe Asn 
1               5                   10                  15


Ala Met Asn Arg Phe Ile Gly Ala Val Asn Asn Met Asp Gln Thr Val 
            20                  25                  30


Met Val Pro Ser Leu Leu Arg Asp Val Pro Leu Ala Asp Pro Gly Leu 
        35                  40                  45


Asp Asn Asp Val Gly Val Glu Val Gly Gly Ser Gly Gly Cys Leu Glu 
    50                  55                  60


Glu Arg Thr Pro Pro Val Pro Asp Ser Gly Ser Ala Asn Gly Ser Phe 
65                  70                  75                  80


Phe Ala Pro Ser Arg Asp Met Tyr Ser His Tyr Val Leu Leu Lys Ser 
                85                  90                  95


Ile Arg Asn Asp Ile Glu Trp Gly Val Leu His Gln Pro Pro Pro Pro 
            100                 105                 110


Ala Gly Ser Glu Glu Gly Ser Ala Trp Lys Ser Lys Asp Ile Leu Val 
        115                 120                 125


Asp Leu Gly His Leu Glu Gly Ala Asp Ala Gly Glu Glu Asp Leu Glu 
    130                 135                 140


Gln Gln Phe His Tyr His Leu Arg Gly Leu His Thr Val Leu Ser Lys 
145                 150                 155                 160


Leu Thr Arg Lys Ala Asn Ile Leu Thr Asn Arg Tyr Lys Gln Glu Ile 
                165                 170                 175


Gly Phe Gly Asn Trp Gly His 
            180


<210>  1338
<211>  3346
<212>  DNA
<213>  Homo sapiens

<400>  1338
gagtagacag cacagcggca gcggagggag tctatgcgag ctggacagca gtgggaggtt     60

tgtgaggctc gcactggccg cagaccctcg ggctcgatcg cccgggagcc aggactcggc    120

gacgcgaggc tgccgggcta cccggccgag gcttcggggg cgcaaactaa tgggactggc    180

tcgctcggca gcatctcccc gctcttctaa gtacactgag cagggcccgc gctgaagtag    240

aagctgtccg ggggcgcgta gcccggagtc ccagtgtggc ccggaggaac ggagcccgtg    300

ccagggcggc ccagtcggga gcccggggac cgagcttgtg ctgtggggaa acccccactt    360

cttccaaggg acagcgatcc cgggacggtc gaggcgtcgg ggcggtcacc gagacctctg    420

cgggaagacc ccgtcgggga gagggcgcgc agccccgaag cgtctcggga agtcgagcgg    480

aatcgggcgg gatcacccgg gggcgcagag cccccgtcgc gcctcgtgcg gcagcggaga    540

gcccaggaga acgagccctc gggggccgaa gcccatgccc gggttggggg cggctgccca    600

gtgagtcctc ctggccggcc gggcggagaa gagcgacacc gaagccggcg ggaggggagc    660

acttcaaggc cggcggctgc ggaggatggg cgcctgagcg gctccgagcg cagcgcggca    720

gaggaaggcg aggcgagctt tggtgaggag gcgccaaggg atcccgaagt gcagtctgcc    780

cccgggaaga tggctcggcc tgggcagcgt tggctcggca agtggcttgt ggcgatggtc    840

gtgtgggcgc tgtgccggct cgccacaccg ctggccaaga acctggagcc cgtatcctgg    900

agctccctca accccaagtt cctgagtggg aagggcttgg tgatctatcc gaaaattgga    960

gacaagctgg acatcatctg cccccgagca gaagcagggc ggccctatga gtactacaag   1020

ctgtacctgg tgcggcctga gcaggcagct gcctgtagca cagttctcga ccccaacgtg   1080

ttggtcacct gcaataggcc agagcaggaa atacgcttta ccatcaagtt ccaggagttc   1140

agccccaact acatgggcct ggagttcaag aagcaccatg attactacat tacctcaaca   1200

tccaatggaa gcctggaggg gctggaaaac cgggagggcg gtgtgtgccg cacacgcacc   1260

atgaagatca tcatgaaggt tgggcaagat cccaatgctg tgacgcctga gcagctgact   1320

accagcaggc ccagcaagga ggcagacaac actgtcaaga tggccacaca ggcccctggt   1380

agtcggggct ccctgggtga ctctgatggc aagcatgaga ctgtgaacca ggaagagaag   1440

agtggcccag gtgcaagtgg gggcagcagc ggggaccctg atggcttctt caactccaag   1500

gtggcattgt tcgcggctgt cggtgccggt tgcgtcatct tcctgctcat catcatcttc   1560

ctgacggtcc tactactgaa gctacgcaag cggcaccgca agcacacaca gcagcgggcg   1620

gctgccctct cgctcagtac cctggccagt cccaaggggg gcagtggcac agcgggcacc   1680

gagcccagcg acatcatcat tcccttacgg actacagaga acaactactg cccccactat   1740

gagaaggtga gtggggacta cgggcaccct gtctacatcg tccaagagat gccgccccag   1800

agcccggcga acatctacta caaggtctga gtgcccggca cggcctcagg cccccgaggg   1860

acagtcggcc tggaccggac ctctcctttc gcccccacac cccctcccct tgccagctgt   1920

gcccaccttt gtatttagtt ttgtagtttc ttggctttta taatccccct ttttccctgc   1980

cccctgggct tcggaggggg gtgcttgtgc ccctaacccc catgctcttg tgccttcccc   2040

ctctggccag gcctctgggc tccgtggggg cgccccttct tggaaggcag ggctggacac   2100

tgatggacag caggcaggga gacagtcccc tggccctgcc cctccctcgc cccccttgcc   2160

accttcccag gactgcttgt ccgctatcat cactgttttt aatgcttttg tgttcatttt   2220

ttagctgtca actcattttc atctgttttt tgaagaaaaa tggaaaaatg taaaaggcag   2280

cccctcccca ggctttgtga gcctggccca agccagtaca agagggcctg gggcacgatg   2340

tggtcagcca ggaagcatag gatgccattt cttttataga ttccttggta tttctggtgg   2400

ggtaaggggc aggccagggc tgttcacgcc catgagggaa gaggaaagtg ccactgggca   2460

aggtgtccca ccctcccctc ctgaccctcc tacgaggctt atcctggcaa tggggtagtc   2520

actgccaccc ttccacacac acacacacac acacacacac aaaaaaaaat cccttccttg   2580

tgggattctt gggcatctcc tgcctccctc actctcacgg taattaatgt cttaattggc   2640

tgttgcctgg ggaacaggag agctgctgca ggcagatgac ctcatggggg gtggagggag   2700

gtgaggtgcc caggtggcta tttgccctgc agagctggga gtttcacccc caccccccac   2760

cctgttctct ccttaccttt ggcatccttt ggcctggtgg ggaaacagag gcccagggtg   2820

gagacctaag cgggtataag accaggtggc ctgctccttt tctgggccct agcacaggtg   2880

ggtaaccccc acccaaccca gctcctgctg ctgtcccagt cttgggctgg ggcctggaaa   2940

gaggaagagg ctgcctgggg ctgggccagc ccgctgtgca ctttgacccc agttccttgc   3000

cagcacggct gctaacagac tgccacttga gtgcgccttg caggcactcc cagagcagcc   3060

atggaaggag ctggccctca caccatccac ctccacactg cctcctggcc agctgcccac   3120

cccagtgcca ggtgggagag ggagcagaac agccagcccc ttccaggtgg cagtcggaag   3180

ggtttttgtt tttgtttctg ttgccatttg tgtaaatact agtctttttg gaaaaaaaat   3240

aatgtaaaga tgttttgtat aaactctgaa ttattttctt gttgcttttt tcttagaaaa   3300

aaatgagaac taaaaaaaaa aaattaacca catggaaaaa aaaaaa                  3346


<210>  1339
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  1339

Met Ala Arg Pro Gly Gln Arg Trp Leu Gly Lys Trp Leu Val Ala Met 
1               5                   10                  15


Val Val Trp Ala Leu Cys Arg Leu Ala Thr Pro Leu Ala Lys Asn Leu 
            20                  25                  30


Glu Pro Val Ser Trp Ser Ser Leu Asn Pro Lys Phe Leu Ser Gly Lys 
        35                  40                  45


Gly Leu Val Ile Tyr Pro Lys Ile Gly Asp Lys Leu Asp Ile Ile Cys 
    50                  55                  60


Pro Arg Ala Glu Ala Gly Arg Pro Tyr Glu Tyr Tyr Lys Leu Tyr Leu 
65                  70                  75                  80


Val Arg Pro Glu Gln Ala Ala Ala Cys Ser Thr Val Leu Asp Pro Asn 
                85                  90                  95


Val Leu Val Thr Cys Asn Arg Pro Glu Gln Glu Ile Arg Phe Thr Ile 
            100                 105                 110


Lys Phe Gln Glu Phe Ser Pro Asn Tyr Met Gly Leu Glu Phe Lys Lys 
        115                 120                 125


His His Asp Tyr Tyr Ile Thr Ser Thr Ser Asn Gly Ser Leu Glu Gly 
    130                 135                 140


Leu Glu Asn Arg Glu Gly Gly Val Cys Arg Thr Arg Thr Met Lys Ile 
145                 150                 155                 160


Ile Met Lys Val Gly Gln Asp Pro Asn Ala Val Thr Pro Glu Gln Leu 
                165                 170                 175


Thr Thr Ser Arg Pro Ser Lys Glu Ala Asp Asn Thr Val Lys Met Ala 
            180                 185                 190


Thr Gln Ala Pro Gly Ser Arg Gly Ser Leu Gly Asp Ser Asp Gly Lys 
        195                 200                 205


His Glu Thr Val Asn Gln Glu Glu Lys Ser Gly Pro Gly Ala Ser Gly 
    210                 215                 220


Gly Ser Ser Gly Asp Pro Asp Gly Phe Phe Asn Ser Lys Val Ala Leu 
225                 230                 235                 240


Phe Ala Ala Val Gly Ala Gly Cys Val Ile Phe Leu Leu Ile Ile Ile 
                245                 250                 255


Phe Leu Thr Val Leu Leu Leu Lys Leu Arg Lys Arg His Arg Lys His 
            260                 265                 270


Thr Gln Gln Arg Ala Ala Ala Leu Ser Leu Ser Thr Leu Ala Ser Pro 
        275                 280                 285


Lys Gly Gly Ser Gly Thr Ala Gly Thr Glu Pro Ser Asp Ile Ile Ile 
    290                 295                 300


Pro Leu Arg Thr Thr Glu Asn Asn Tyr Cys Pro His Tyr Glu Lys Val 
305                 310                 315                 320


Ser Gly Asp Tyr Gly His Pro Val Tyr Ile Val Gln Glu Met Pro Pro 
                325                 330                 335


Gln Ser Pro Ala Asn Ile Tyr Tyr Lys Val 
            340                 345


<210>  1340
<211>  3151
<212>  DNA
<213>  Homo sapiens

<400>  1340
gtcctcgtgc gctgtggacg gaggttgtgg agagagcagg gcggcattgg tggctgcggc     60

tgaggcttga gccagagatt taaaaatgga caatgatgat tttttttcca tggactttaa    120

agatggagtc tgtctctgtt gtccaggctg gagtgcagtg gcatgatctc ggctcactgc    180

aacctccgcc tcctgtgttc aagcgattct tctgcctcag cctcccaagt agctgggact    240

acagaagttg ttgaaaacct ggttacaaat gataattcac ctaacatacc agaggcaatt    300

gatagactct tcagcgacat agcaaatatc aacagggagt ctatggctga aataacagac    360

attcagattg aagaaatggc agtaaaccta tggaactggg cacttaccat aggaggaggt    420

tggcttgtaa atgaagagca gaaaattaga ttacattatg ttgcttgcaa gttgctgagt    480

atgtgtgaag cctcatttgc ctcagaacaa agtattcaac gactgattat gatgaatatg    540

agaataggaa aagaatggtt ggatgctgga aattttctaa tcgctgatga atgttttcaa    600

gctgctgtgg ccagtctgga gcaattatac gtcaaattaa ttcaaaggag ctcccctgag    660

gctgacttga ccatggagaa gattactgtt gagagtgacc acttcagagt gctttcttac    720

caagcagagt cagcagttgc tcaaggggat tttcaaagag catctatgtg tgtactgcaa    780

tgtaaagata tgttgatgag gctcccccag atgacttcaa gtcttcatca tctctgttac    840

aactttggag tagaaaccca gaagaataat aaatatgaag aaagttcttt ctggcttagc    900

caaagctatg atattgggaa gatggataag aaatctactg ggccagaaat gctggctaaa    960

gttctacggc tattagccac gaattatttg gattgggatg acaccaaata ttatgataag   1020

gctctcaatg ctgtaaacct agcaaacaag gaacatttaa gttctcctgg gcttttctta   1080

aaaatgaaaa tcctcttgaa aggcgaaaca tctaatgaag aactccttga agctgtcatg   1140

gaaatactac atcttgacat gcccttagac ttctgtctga acattgctaa actgctgatg   1200

gatcatgaaa gagaatctgt tgggtttcat ttcctgacga ttattcatga acgttttaag   1260

tcatcggaaa atattggaaa agttctgata ctccatactg acatgctttt acaaaggaag   1320

gaagaacttc ttgccaagga gaagattgaa gaaatctttt tagctcacca aacaggaaga   1380

caactgacag cagaatcaat gaactggtta cacaacattc tgtggagaca agctgccagt   1440

agttttgagg tacaaaatta cactgatgcc ctacaatggt actattattc tctgaggttt   1500

tattcaactg atgaaatgga tctggacttc accaagctgc agaggaacat ggcttgctgt   1560

tacctgaatt tgcaacaact tgataaggcc aaagaggcag tggcagaagc tgaacgacat   1620

gaccctagga acgttttcac tcaattttat atattcaaga ttgcagtcat agagggcaac   1680

tctgaaagag ctttgcaggc aataattact ttagagaata tattaacaga tgaagagtca   1740

gaagataatg atctagttgc agagagaggt tcacctacca tgcttctaag tttagctgcc   1800

cagtttgctc tagagaatgg acaacaaatt gtggcagaaa aagctttgga atatttagct   1860

caacattcag aagaccagga acaagttctt acagctgtaa agtgtttgct tcgttttctt   1920

cttccaaaaa ttgctgaaat gccggaatct gaagataaga agaaagaaat ggatcgactt   1980

ttgacttgcc tgaatagagc ctttgtgaaa ctttctcagc cttttggtga agaagcctta   2040

agtttggagt caagagctaa tgaagctcag tggtttcgaa aaacagcttg gaacttggct   2100

gtgcaatgtg acaaagatcc agtgatgatg agagagtttt ttatactttc ttataagatg   2160

tcccagtttt gtccttctga tcaagtaatt ctgattgcac ggaaaacatg tttacttatg   2220

gcagttgcag ttgatctaga gcaagggaga aaagcttcaa cagcttttga acagaccatg   2280

ttcctgagtc gtgcacttga ggagatccag acatgcaatg acatccataa tttcctgaaa   2340

caaacaggga ccttctcaaa tgattcatgt gagaaattgc ttctgctgta cgagtttgaa   2400

gttagagcca aattgaatga tccattactg gaaagcttcc tggaatcagt gtgggagttg   2460

cctcatttag aaactaaaac ttttgaaaca attgcaataa tagcaatgga aaagcctgca   2520

cactatcctt tgattgctct caaggccttg aaaaaggctt tattgctcta caaaaaggaa   2580

gaaccaattg atatatcaca atacagcaaa tgtatgcaca acttggttaa cctctcagtg   2640

ccagatgggg cgtcgaatgt agagctctgt cccctggaag aagtttgggg ctattttgaa   2700

gatgctctga gccacattag ccgcactaaa gactacccag aaatggagat tctctggctg   2760

atggtcaagt cctggaatac cggagtactt atgtttagca ggagcaagta tgcatctgct   2820

gaaaagtggt gtggcctggc cttgcgtttc cttaaccacc ttacctcctt caaggaaagc   2880

tatgaaactc agatgaatat gctgtatagt cagcttgtgg aagcattgag taacaacaag   2940

ggcccagttt ttcatgaaca tggctactgg agcaagtcag attaggcaag ctcatggcca   3000

catgaagaag atacattgtc ccgagatgct gactgtttaa atttttgcca gagtttctct   3060

tgagcttttg tttctgtttg ctcagaccct gttttcatgt tgttgaataa actttctaaa   3120

ataaaagcat gctgaattta aaaaaaaaaa a                                  3151


<210>  1341
<211>  940
<212>  PRT
<213>  Homo sapiens

<400>  1341

Met Ile Ser Ala His Cys Asn Leu Arg Leu Leu Cys Ser Ser Asp Ser 
1               5                   10                  15


Ser Ala Ser Ala Ser Gln Val Ala Gly Thr Thr Glu Val Val Glu Asn 
            20                  25                  30


Leu Val Thr Asn Asp Asn Ser Pro Asn Ile Pro Glu Ala Ile Asp Arg 
        35                  40                  45


Leu Phe Ser Asp Ile Ala Asn Ile Asn Arg Glu Ser Met Ala Glu Ile 
    50                  55                  60


Thr Asp Ile Gln Ile Glu Glu Met Ala Val Asn Leu Trp Asn Trp Ala 
65                  70                  75                  80


Leu Thr Ile Gly Gly Gly Trp Leu Val Asn Glu Glu Gln Lys Ile Arg 
                85                  90                  95


Leu His Tyr Val Ala Cys Lys Leu Leu Ser Met Cys Glu Ala Ser Phe 
            100                 105                 110


Ala Ser Glu Gln Ser Ile Gln Arg Leu Ile Met Met Asn Met Arg Ile 
        115                 120                 125


Gly Lys Glu Trp Leu Asp Ala Gly Asn Phe Leu Ile Ala Asp Glu Cys 
    130                 135                 140


Phe Gln Ala Ala Val Ala Ser Leu Glu Gln Leu Tyr Val Lys Leu Ile 
145                 150                 155                 160


Gln Arg Ser Ser Pro Glu Ala Asp Leu Thr Met Glu Lys Ile Thr Val 
                165                 170                 175


Glu Ser Asp His Phe Arg Val Leu Ser Tyr Gln Ala Glu Ser Ala Val 
            180                 185                 190


Ala Gln Gly Asp Phe Gln Arg Ala Ser Met Cys Val Leu Gln Cys Lys 
        195                 200                 205


Asp Met Leu Met Arg Leu Pro Gln Met Thr Ser Ser Leu His His Leu 
    210                 215                 220


Cys Tyr Asn Phe Gly Val Glu Thr Gln Lys Asn Asn Lys Tyr Glu Glu 
225                 230                 235                 240


Ser Ser Phe Trp Leu Ser Gln Ser Tyr Asp Ile Gly Lys Met Asp Lys 
                245                 250                 255


Lys Ser Thr Gly Pro Glu Met Leu Ala Lys Val Leu Arg Leu Leu Ala 
            260                 265                 270


Thr Asn Tyr Leu Asp Trp Asp Asp Thr Lys Tyr Tyr Asp Lys Ala Leu 
        275                 280                 285


Asn Ala Val Asn Leu Ala Asn Lys Glu His Leu Ser Ser Pro Gly Leu 
    290                 295                 300


Phe Leu Lys Met Lys Ile Leu Leu Lys Gly Glu Thr Ser Asn Glu Glu 
305                 310                 315                 320


Leu Leu Glu Ala Val Met Glu Ile Leu His Leu Asp Met Pro Leu Asp 
                325                 330                 335


Phe Cys Leu Asn Ile Ala Lys Leu Leu Met Asp His Glu Arg Glu Ser 
            340                 345                 350


Val Gly Phe His Phe Leu Thr Ile Ile His Glu Arg Phe Lys Ser Ser 
        355                 360                 365


Glu Asn Ile Gly Lys Val Leu Ile Leu His Thr Asp Met Leu Leu Gln 
    370                 375                 380


Arg Lys Glu Glu Leu Leu Ala Lys Glu Lys Ile Glu Glu Ile Phe Leu 
385                 390                 395                 400


Ala His Gln Thr Gly Arg Gln Leu Thr Ala Glu Ser Met Asn Trp Leu 
                405                 410                 415


His Asn Ile Leu Trp Arg Gln Ala Ala Ser Ser Phe Glu Val Gln Asn 
            420                 425                 430


Tyr Thr Asp Ala Leu Gln Trp Tyr Tyr Tyr Ser Leu Arg Phe Tyr Ser 
        435                 440                 445


Thr Asp Glu Met Asp Leu Asp Phe Thr Lys Leu Gln Arg Asn Met Ala 
    450                 455                 460


Cys Cys Tyr Leu Asn Leu Gln Gln Leu Asp Lys Ala Lys Glu Ala Val 
465                 470                 475                 480


Ala Glu Ala Glu Arg His Asp Pro Arg Asn Val Phe Thr Gln Phe Tyr 
                485                 490                 495


Ile Phe Lys Ile Ala Val Ile Glu Gly Asn Ser Glu Arg Ala Leu Gln 
            500                 505                 510


Ala Ile Ile Thr Leu Glu Asn Ile Leu Thr Asp Glu Glu Ser Glu Asp 
        515                 520                 525


Asn Asp Leu Val Ala Glu Arg Gly Ser Pro Thr Met Leu Leu Ser Leu 
    530                 535                 540


Ala Ala Gln Phe Ala Leu Glu Asn Gly Gln Gln Ile Val Ala Glu Lys 
545                 550                 555                 560


Ala Leu Glu Tyr Leu Ala Gln His Ser Glu Asp Gln Glu Gln Val Leu 
                565                 570                 575


Thr Ala Val Lys Cys Leu Leu Arg Phe Leu Leu Pro Lys Ile Ala Glu 
            580                 585                 590


Met Pro Glu Ser Glu Asp Lys Lys Lys Glu Met Asp Arg Leu Leu Thr 
        595                 600                 605


Cys Leu Asn Arg Ala Phe Val Lys Leu Ser Gln Pro Phe Gly Glu Glu 
    610                 615                 620


Ala Leu Ser Leu Glu Ser Arg Ala Asn Glu Ala Gln Trp Phe Arg Lys 
625                 630                 635                 640


Thr Ala Trp Asn Leu Ala Val Gln Cys Asp Lys Asp Pro Val Met Met 
                645                 650                 655


Arg Glu Phe Phe Ile Leu Ser Tyr Lys Met Ser Gln Phe Cys Pro Ser 
            660                 665                 670


Asp Gln Val Ile Leu Ile Ala Arg Lys Thr Cys Leu Leu Met Ala Val 
        675                 680                 685


Ala Val Asp Leu Glu Gln Gly Arg Lys Ala Ser Thr Ala Phe Glu Gln 
    690                 695                 700


Thr Met Phe Leu Ser Arg Ala Leu Glu Glu Ile Gln Thr Cys Asn Asp 
705                 710                 715                 720


Ile His Asn Phe Leu Lys Gln Thr Gly Thr Phe Ser Asn Asp Ser Cys 
                725                 730                 735


Glu Lys Leu Leu Leu Leu Tyr Glu Phe Glu Val Arg Ala Lys Leu Asn 
            740                 745                 750


Asp Pro Leu Leu Glu Ser Phe Leu Glu Ser Val Trp Glu Leu Pro His 
        755                 760                 765


Leu Glu Thr Lys Thr Phe Glu Thr Ile Ala Ile Ile Ala Met Glu Lys 
    770                 775                 780


Pro Ala His Tyr Pro Leu Ile Ala Leu Lys Ala Leu Lys Lys Ala Leu 
785                 790                 795                 800


Leu Leu Tyr Lys Lys Glu Glu Pro Ile Asp Ile Ser Gln Tyr Ser Lys 
                805                 810                 815


Cys Met His Asn Leu Val Asn Leu Ser Val Pro Asp Gly Ala Ser Asn 
            820                 825                 830


Val Glu Leu Cys Pro Leu Glu Glu Val Trp Gly Tyr Phe Glu Asp Ala 
        835                 840                 845


Leu Ser His Ile Ser Arg Thr Lys Asp Tyr Pro Glu Met Glu Ile Leu 
    850                 855                 860


Trp Leu Met Val Lys Ser Trp Asn Thr Gly Val Leu Met Phe Ser Arg 
865                 870                 875                 880


Ser Lys Tyr Ala Ser Ala Glu Lys Trp Cys Gly Leu Ala Leu Arg Phe 
                885                 890                 895


Leu Asn His Leu Thr Ser Phe Lys Glu Ser Tyr Glu Thr Gln Met Asn 
            900                 905                 910


Met Leu Tyr Ser Gln Leu Val Glu Ala Leu Ser Asn Asn Lys Gly Pro 
        915                 920                 925


Val Phe His Glu His Gly Tyr Trp Ser Lys Ser Asp 
    930                 935                 940


<210>  1342
<211>  3029
<212>  DNA
<213>  Homo sapiens

<400>  1342
gtcctcgtgc gctgtggacg gaggttgtgg agagagcagg gcggcattgg tggctgcggc     60

tgaggcttga gccagagatt taaaaatgga caatgatgat tttttttcca tggactttaa    120

agaagttgtt gaaaacctgg ttacaaatga taattcacct aacataccag aggcaattga    180

tagactcttc agcgacatag caaatatcaa cagggagtct atggctgaaa taacagacat    240

tcagattgaa gaaatggcag taaacctatg gaactgggca cttaccatag gaggaggttg    300

gcttgtaaat gaagagcaga aaattagatt acattatgtt gcttgcaagt tgctgagtat    360

gtgtgaagcc tcatttgcct cagaacaaag tattcaacga ctgattatga tgaatatgag    420

aataggaaaa gaatggttgg atgctggaaa ttttctaatc gctgatgaat gttttcaagc    480

tgctgtggcc agtctggagc aattatacgt caaattaatt caaaggagct cccctgaggc    540

tgacttgacc atggagaaga ttactgttga gagtgaccac ttcagagtgc tttcttacca    600

agcagagtca gcagttgctc aaggggattt tcaaagagca tctatgtgtg tactgcaatg    660

taaagatatg ttgatgaggc tcccccagat gacttcaagt cttcatcatc tctgttacaa    720

ctttggagta gaaacccaga agaataataa atatgaagaa agttctttct ggcttagcca    780

aagctatgat attgggaaga tggataagaa atctactggg ccagaaatgc tggctaaagt    840

tctacggcta ttagccacga attatttgga ttgggatgac accaaatatt atgataaggc    900

tctcaatgct gtaaacctag caaacaagga acatttaagt tctcctgggc ttttcttaaa    960

aatgaaaatc ctcttgaaag gcgaaacatc taatgaagaa ctccttgaag ctgtcatgga   1020

aatactacat cttgacatgc ccttagactt ctgtctgaac attgctaaac tgctgatgga   1080

tcatgaaaga gaatctgttg ggtttcattt cctgacgatt attcatgaac gttttaagtc   1140

atcggaaaat attggaaaag ttctgatact ccatactgac atgcttttac aaaggaagga   1200

agaacttctt gccaaggaga agattgaaga aatcttttta gctcaccaaa caggaagaca   1260

actgacagca gaatcaatga actggttaca caacattctg tggagacaag ctgccagtag   1320

ttttgaggta caaaattaca ctgatgccct acaatggtac tattattctc tgaggtttta   1380

ttcaactgat gaaatggatc tggacttcac caagctgcag aggaacatgg cttgctgtta   1440

cctgaatttg caacaacttg ataaggccaa agaggcagtg gcagaagctg aacgacatga   1500

ccctaggaac gttttcactc aattttatat attcaagatt gcagtcatag agggcaactc   1560

tgaaagagct ttgcaggcaa taattacttt agagaatata ttaacagatg aagagtcaga   1620

agataatgat ctagttgcag agagaggttc acctaccatg cttctaagtt tagctgccca   1680

gtttgctcta gagaatggac aacaaattgt ggcagaaaaa gctttggaat atttagctca   1740

acattcagaa gaccaggaac aagttcttac agctgtaaag tgtttgcttc gttttcttct   1800

tccaaaaatt gctgaaatgc cggaatctga agataagaag aaagaaatgg atcgactttt   1860

gacttgcctg aatagagcct ttgtgaaact ttctcagcct tttggtgaag aagccttaag   1920

tttggagtca agagctaatg aagctcagtg gtttcgaaaa acagcttgga acttggctgt   1980

gcaatgtgac aaagatccag tgatgatgag agagtttttt atactttctt ataagatgtc   2040

ccagttttgt ccttctgatc aagtaattct gattgcacgg aaaacatgtt tacttatggc   2100

agttgcagtt gatctagagc aagggagaaa agcttcaaca gcttttgaac agaccatgtt   2160

cctgagtcgt gcacttgagg agatccagac atgcaatgac atccataatt tcctgaaaca   2220

aacagggacc ttctcaaatg attcatgtga gaaattgctt ctgctgtacg agtttgaagt   2280

tagagccaaa ttgaatgatc cattactgga aagcttcctg gaatcagtgt gggagttgcc   2340

tcatttagaa actaaaactt ttgaaacaat tgcaataata gcaatggaaa agcctgcaca   2400

ctatcctttg attgctctca aggccttgaa aaaggcttta ttgctctaca aaaaggaaga   2460

accaattgat atatcacaat acagcaaatg tatgcacaac ttggttaacc tctcagtgcc   2520

agatggggcg tcgaatgtag agctctgtcc cctggaagaa gtttggggct attttgaaga   2580

tgctctgagc cacattagcc gcactaaaga ctacccagaa atggagattc tctggctgat   2640

ggtcaagtcc tggaataccg gagtacttat gtttagcagg agcaagtatg catctgctga   2700

aaagtggtgt ggcctggcct tgcgtttcct taaccacctt acctccttca aggaaagcta   2760

tgaaactcag atgaatatgc tgtatagtca gcttgtggaa gcattgagta acaacaaggg   2820

cccagttttt catgaacatg gctactggag caagtcagat taggcaagct catggccaca   2880

tgaagaagat acattgtccc gagatgctga ctgtttaaat ttttgccaga gtttctcttg   2940

agcttttgtt tctgtttgct cagaccctgt tttcatgttg ttgaataaac tttctaaaat   3000

aaaagcatgc tgaatttaaa aaaaaaaaa                                     3029


<210>  1343
<211>  925
<212>  PRT
<213>  Homo sapiens

<400>  1343

Met Asp Asn Asp Asp Phe Phe Ser Met Asp Phe Lys Glu Val Val Glu 
1               5                   10                  15


Asn Leu Val Thr Asn Asp Asn Ser Pro Asn Ile Pro Glu Ala Ile Asp 
            20                  25                  30


Arg Leu Phe Ser Asp Ile Ala Asn Ile Asn Arg Glu Ser Met Ala Glu 
        35                  40                  45


Ile Thr Asp Ile Gln Ile Glu Glu Met Ala Val Asn Leu Trp Asn Trp 
    50                  55                  60


Ala Leu Thr Ile Gly Gly Gly Trp Leu Val Asn Glu Glu Gln Lys Ile 
65                  70                  75                  80


Arg Leu His Tyr Val Ala Cys Lys Leu Leu Ser Met Cys Glu Ala Ser 
                85                  90                  95


Phe Ala Ser Glu Gln Ser Ile Gln Arg Leu Ile Met Met Asn Met Arg 
            100                 105                 110


Ile Gly Lys Glu Trp Leu Asp Ala Gly Asn Phe Leu Ile Ala Asp Glu 
        115                 120                 125


Cys Phe Gln Ala Ala Val Ala Ser Leu Glu Gln Leu Tyr Val Lys Leu 
    130                 135                 140


Ile Gln Arg Ser Ser Pro Glu Ala Asp Leu Thr Met Glu Lys Ile Thr 
145                 150                 155                 160


Val Glu Ser Asp His Phe Arg Val Leu Ser Tyr Gln Ala Glu Ser Ala 
                165                 170                 175


Val Ala Gln Gly Asp Phe Gln Arg Ala Ser Met Cys Val Leu Gln Cys 
            180                 185                 190


Lys Asp Met Leu Met Arg Leu Pro Gln Met Thr Ser Ser Leu His His 
        195                 200                 205


Leu Cys Tyr Asn Phe Gly Val Glu Thr Gln Lys Asn Asn Lys Tyr Glu 
    210                 215                 220


Glu Ser Ser Phe Trp Leu Ser Gln Ser Tyr Asp Ile Gly Lys Met Asp 
225                 230                 235                 240


Lys Lys Ser Thr Gly Pro Glu Met Leu Ala Lys Val Leu Arg Leu Leu 
                245                 250                 255


Ala Thr Asn Tyr Leu Asp Trp Asp Asp Thr Lys Tyr Tyr Asp Lys Ala 
            260                 265                 270


Leu Asn Ala Val Asn Leu Ala Asn Lys Glu His Leu Ser Ser Pro Gly 
        275                 280                 285


Leu Phe Leu Lys Met Lys Ile Leu Leu Lys Gly Glu Thr Ser Asn Glu 
    290                 295                 300


Glu Leu Leu Glu Ala Val Met Glu Ile Leu His Leu Asp Met Pro Leu 
305                 310                 315                 320


Asp Phe Cys Leu Asn Ile Ala Lys Leu Leu Met Asp His Glu Arg Glu 
                325                 330                 335


Ser Val Gly Phe His Phe Leu Thr Ile Ile His Glu Arg Phe Lys Ser 
            340                 345                 350


Ser Glu Asn Ile Gly Lys Val Leu Ile Leu His Thr Asp Met Leu Leu 
        355                 360                 365


Gln Arg Lys Glu Glu Leu Leu Ala Lys Glu Lys Ile Glu Glu Ile Phe 
    370                 375                 380


Leu Ala His Gln Thr Gly Arg Gln Leu Thr Ala Glu Ser Met Asn Trp 
385                 390                 395                 400


Leu His Asn Ile Leu Trp Arg Gln Ala Ala Ser Ser Phe Glu Val Gln 
                405                 410                 415


Asn Tyr Thr Asp Ala Leu Gln Trp Tyr Tyr Tyr Ser Leu Arg Phe Tyr 
            420                 425                 430


Ser Thr Asp Glu Met Asp Leu Asp Phe Thr Lys Leu Gln Arg Asn Met 
        435                 440                 445


Ala Cys Cys Tyr Leu Asn Leu Gln Gln Leu Asp Lys Ala Lys Glu Ala 
    450                 455                 460


Val Ala Glu Ala Glu Arg His Asp Pro Arg Asn Val Phe Thr Gln Phe 
465                 470                 475                 480


Tyr Ile Phe Lys Ile Ala Val Ile Glu Gly Asn Ser Glu Arg Ala Leu 
                485                 490                 495


Gln Ala Ile Ile Thr Leu Glu Asn Ile Leu Thr Asp Glu Glu Ser Glu 
            500                 505                 510


Asp Asn Asp Leu Val Ala Glu Arg Gly Ser Pro Thr Met Leu Leu Ser 
        515                 520                 525


Leu Ala Ala Gln Phe Ala Leu Glu Asn Gly Gln Gln Ile Val Ala Glu 
    530                 535                 540


Lys Ala Leu Glu Tyr Leu Ala Gln His Ser Glu Asp Gln Glu Gln Val 
545                 550                 555                 560


Leu Thr Ala Val Lys Cys Leu Leu Arg Phe Leu Leu Pro Lys Ile Ala 
                565                 570                 575


Glu Met Pro Glu Ser Glu Asp Lys Lys Lys Glu Met Asp Arg Leu Leu 
            580                 585                 590


Thr Cys Leu Asn Arg Ala Phe Val Lys Leu Ser Gln Pro Phe Gly Glu 
        595                 600                 605


Glu Ala Leu Ser Leu Glu Ser Arg Ala Asn Glu Ala Gln Trp Phe Arg 
    610                 615                 620


Lys Thr Ala Trp Asn Leu Ala Val Gln Cys Asp Lys Asp Pro Val Met 
625                 630                 635                 640


Met Arg Glu Phe Phe Ile Leu Ser Tyr Lys Met Ser Gln Phe Cys Pro 
                645                 650                 655


Ser Asp Gln Val Ile Leu Ile Ala Arg Lys Thr Cys Leu Leu Met Ala 
            660                 665                 670


Val Ala Val Asp Leu Glu Gln Gly Arg Lys Ala Ser Thr Ala Phe Glu 
        675                 680                 685


Gln Thr Met Phe Leu Ser Arg Ala Leu Glu Glu Ile Gln Thr Cys Asn 
    690                 695                 700


Asp Ile His Asn Phe Leu Lys Gln Thr Gly Thr Phe Ser Asn Asp Ser 
705                 710                 715                 720


Cys Glu Lys Leu Leu Leu Leu Tyr Glu Phe Glu Val Arg Ala Lys Leu 
                725                 730                 735


Asn Asp Pro Leu Leu Glu Ser Phe Leu Glu Ser Val Trp Glu Leu Pro 
            740                 745                 750


His Leu Glu Thr Lys Thr Phe Glu Thr Ile Ala Ile Ile Ala Met Glu 
        755                 760                 765


Lys Pro Ala His Tyr Pro Leu Ile Ala Leu Lys Ala Leu Lys Lys Ala 
    770                 775                 780


Leu Leu Leu Tyr Lys Lys Glu Glu Pro Ile Asp Ile Ser Gln Tyr Ser 
785                 790                 795                 800


Lys Cys Met His Asn Leu Val Asn Leu Ser Val Pro Asp Gly Ala Ser 
                805                 810                 815


Asn Val Glu Leu Cys Pro Leu Glu Glu Val Trp Gly Tyr Phe Glu Asp 
            820                 825                 830


Ala Leu Ser His Ile Ser Arg Thr Lys Asp Tyr Pro Glu Met Glu Ile 
        835                 840                 845


Leu Trp Leu Met Val Lys Ser Trp Asn Thr Gly Val Leu Met Phe Ser 
    850                 855                 860


Arg Ser Lys Tyr Ala Ser Ala Glu Lys Trp Cys Gly Leu Ala Leu Arg 
865                 870                 875                 880


Phe Leu Asn His Leu Thr Ser Phe Lys Glu Ser Tyr Glu Thr Gln Met 
                885                 890                 895


Asn Met Leu Tyr Ser Gln Leu Val Glu Ala Leu Ser Asn Asn Lys Gly 
            900                 905                 910


Pro Val Phe His Glu His Gly Tyr Trp Ser Lys Ser Asp 
        915                 920                 925


<210>  1344
<211>  3521
<212>  DNA
<213>  Homo sapiens

<400>  1344
aggaagcggg aagttactta gcacggttcc gggtttctcg cgccccgcct gtcccccctc     60

cctatcactg ctactggctc ttggtccctc cgttggactg tcctgcggag agaaacccca    120

gcccatcggt ctgcgctggg accgcccgcc gcgcatctgc ccttcttcgc tgactccgcc    180

ccgcatctgg ccagacccgc ctcgcgtcag agctgaccca ctcactgcgc gtttgccagt    240

cagtctctcc ggacctgcct cgagcctcag gctgctgaaa tcaccgcgcc tcactcgcct    300

cgacagtgat tctgagtctg cttttagctt ccttttgcct gccttggctt tttctgttcg    360

tgaacagctg tttggcccat agcttagaga aagcagcctt ttttctcttc aaagagaacc    420

tcctcccagt gctcagagag atggggagcg gggagcctaa tcctgctggc aagaaaaaga    480

agtatctcaa ggccgctctg tacgtgggtg acttggaccc agatgtcacc gaggacatgc    540

tctataagaa gttcaggcct gctggccctc tgcgattcac ccgaatctgc cgtgatccgg    600

tgacccgcag ccccctgggc tatgggtatg ttaacttccg ctttcccgcg gatgcagagt    660

gggccttgaa caccatgaat tttgatttga ttaatggaaa accattccgc cttatgtggt    720

ctcagccaga tgaccgctta agaaagtctg gagtgggaaa tatattcatc aaaaacctgg    780

acaaatccat agacaatagg gccctgtttt acttattttc tgcttttggg aacattctgt    840

cctgcaaagt cgtatgcgat gacaacggct ctaagggtta tgcctatgtt cactttgaca    900

gcctggccgc tgccaataga gccatctggc acatgaatgg agtgcggctc aacaaccgcc    960

aggtgtatgt tggcagattc aaattcccag aagagcgggc ggctgaggtc agaaccaggg   1020

atagagcaac tttcaccaat gttttcgtta aaaacattgg agacgacata gatgacgaaa   1080

aactgaagga acttttctgt gaatatgggc caactgagag tgttaaagta ataagagatg   1140

ccagtgggaa atctaaaggc tttggatttg tgagatatga gacacacgag gctgcccaaa   1200

aggctgtgct agacttgcat ggaaagtcca tcgatggaaa agtcctctat gtagggcgag   1260

cacagaagaa aattgaacgc ctggctgagt tgaggcggag atttgaacgg ctgaggttaa   1320

aagaaaaaag tcggccccca ggggtgccta tctatattaa gaacttggat gagacaatca   1380

atgatgaaaa actgaaggag gaattttctt cctttgggtc aattagtcgg gccaaagtga   1440

tgatggaagt ggggcaaggc aaaggatttg gtgtggtctg cttttcctct tttgaagagg   1500

ctaccaaagc agtggatgag atgaatggcc gcatagtggg ctccaagccc ctgcatgtca   1560

ccctgggcca ggccaggcgc aggtgctgag aataagaatg ctcagtttgt ttcagcctta   1620

gttggtgcct ccttagtttg ggctcctttg tgataagggg ttattttatg ctaattcaca   1680

agtttttttt gaagtgaatt cttttgaaaa aaaaatgcaa aactagaaaa ctttattcat   1740

tttagaatag aacataattt ctaactgtaa aattgtcatt ttgtactttt tttgatgtaa   1800

tatccttaga aatctgtaga ataaagtgta ttcctccact tttttttcct gaacagtcaa   1860

ggtgaggcaa ttgattgagt atatttccct tcttatttca gtaatactct attttttttc   1920

atgaaaatgt caacatggtt cttctgaatc tatcacagtg aaaagttcta acttgttttt   1980

gagaagtcag tacagcaggg gaaaacatat gtgatgcaat taacatctgc ataatttcac   2040

ttaaaattat tatgcaaaaa tgaatgtttt ttcaaaaaat gtgaaatgta ttttattttc   2100

tttatttgta ttcttgtttc attttttaat atgttgtgaa catgctacag atttgatagt   2160

acttttgact aaatgttggg agtggtcgta ttaacttctt gcccaaagaa gtaagcatat   2220

tggtgttttc tcaattagtc actgagaaaa ttaacacttt aggcagtggc tatttaaagt   2280

aggaattgca tcttaaaaac ctttcctaag agatttggta tgtgaggata ctttcagtac   2340

cactcctacc attcattttt ctaaattcct tagtacatat acttggatca tgttaaatta   2400

acaagaaaga tgaataactg cgctgaattg cctttaccta taaataattt aatattttac   2460

cttcgggttt tatcaactgt caatataaaa ggcagtactc cacagaatga tgttgaaaaa   2520

cttcttcgaa gaacaccttc tattaaactt gttatctctt gtaaattatt gtgtgtgtcc   2580

ttttgataat attcacaggt gtttcaaagg taaggaatag gttgtctctt ggattaagtc   2640

atatgcctcc agccattata tgagaactgt gaaaccaata tggttttctt tatgtcttgg   2700

ctgcttgaaa attaaaaaaa aaaaaggttt gttcaatatt gccgttacat ttattagcct   2760

gtaatttcta aattggagat tctctacatt tcacttgcag tttcctgttc tcctcattgc   2820

ctgccttcca ttcatattac acttattttt ctattttttg tattaccttt ttaaaaatat   2880

ataccagttc aagtcctttt aggaagaaga aaatacctaa tttatgtaaa atttaaataa   2940

ttactttttt ataatatgat tcacttatgc cacagattca acattagaat atgttttatc   3000

tctactgtca gttttattac cttatataca aatcttcatt ttcatacata gtacaatgta   3060

aatatataac tttgttaaca cttttgttag ctctttgacc ataaaataat gacaataagc   3120

tgtttctatg tatttgttta tctacaaatt acaggtttat ccatttgcaa atattttcaa   3180

aatggaaatc actgtttata ttgattataa acataagaca tgctcattgt aaaaaatgta   3240

cacaaggcag aaggaagtaa aatttccaca gttcagaaat accacaatta atattttcaa   3300

tgtgtaaata tcttttcata ttttttccta cgtatacaca aacattttga ccaaaaatcc   3360

acactatatg tactgttctg tatttttaat tttaaactga acaataatca tcttttcctg   3420

acaataaata tcaatctcta tcatcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3480

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                       3521


<210>  1345
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  1345

Met Gly Ser Gly Glu Pro Asn Pro Ala Gly Lys Lys Lys Lys Tyr Leu 
1               5                   10                  15


Lys Ala Ala Leu Tyr Val Gly Asp Leu Asp Pro Asp Val Thr Glu Asp 
            20                  25                  30


Met Leu Tyr Lys Lys Phe Arg Pro Ala Gly Pro Leu Arg Phe Thr Arg 
        35                  40                  45


Ile Cys Arg Asp Pro Val Thr Arg Ser Pro Leu Gly Tyr Gly Tyr Val 
    50                  55                  60


Asn Phe Arg Phe Pro Ala Asp Ala Glu Trp Ala Leu Asn Thr Met Asn 
65                  70                  75                  80


Phe Asp Leu Ile Asn Gly Lys Pro Phe Arg Leu Met Trp Ser Gln Pro 
                85                  90                  95


Asp Asp Arg Leu Arg Lys Ser Gly Val Gly Asn Ile Phe Ile Lys Asn 
            100                 105                 110


Leu Asp Lys Ser Ile Asp Asn Arg Ala Leu Phe Tyr Leu Phe Ser Ala 
        115                 120                 125


Phe Gly Asn Ile Leu Ser Cys Lys Val Val Cys Asp Asp Asn Gly Ser 
    130                 135                 140


Lys Gly Tyr Ala Tyr Val His Phe Asp Ser Leu Ala Ala Ala Asn Arg 
145                 150                 155                 160


Ala Ile Trp His Met Asn Gly Val Arg Leu Asn Asn Arg Gln Val Tyr 
                165                 170                 175


Val Gly Arg Phe Lys Phe Pro Glu Glu Arg Ala Ala Glu Val Arg Thr 
            180                 185                 190


Arg Asp Arg Ala Thr Phe Thr Asn Val Phe Val Lys Asn Ile Gly Asp 
        195                 200                 205


Asp Ile Asp Asp Glu Lys Leu Lys Glu Leu Phe Cys Glu Tyr Gly Pro 
    210                 215                 220


Thr Glu Ser Val Lys Val Ile Arg Asp Ala Ser Gly Lys Ser Lys Gly 
225                 230                 235                 240


Phe Gly Phe Val Arg Tyr Glu Thr His Glu Ala Ala Gln Lys Ala Val 
                245                 250                 255


Leu Asp Leu His Gly Lys Ser Ile Asp Gly Lys Val Leu Tyr Val Gly 
            260                 265                 270


Arg Ala Gln Lys Lys Ile Glu Arg Leu Ala Glu Leu Arg Arg Arg Phe 
        275                 280                 285


Glu Arg Leu Arg Leu Lys Glu Lys Ser Arg Pro Pro Gly Val Pro Ile 
    290                 295                 300


Tyr Ile Lys Asn Leu Asp Glu Thr Ile Asn Asp Glu Lys Leu Lys Glu 
305                 310                 315                 320


Glu Phe Ser Ser Phe Gly Ser Ile Ser Arg Ala Lys Val Met Met Glu 
                325                 330                 335


Val Gly Gln Gly Lys Gly Phe Gly Val Val Cys Phe Ser Ser Phe Glu 
            340                 345                 350


Glu Ala Thr Lys Ala Val Asp Glu Met Asn Gly Arg Ile Val Gly Ser 
        355                 360                 365


Lys Pro Leu His Val Thr Leu Gly Gln Ala Arg Arg Arg Cys 
    370                 375                 380


<210>  1346
<211>  1040
<212>  DNA
<213>  Homo sapiens

<400>  1346
gctttctgcg ctacctacag aggggtccat atggcgttgt tctggattcc catcgtaact     60

taaagggaaa ctttcgcaat gtccggagcg cttgatatcc tgcaaatgaa ggaggaggat    120

gtccttaagt tccttgcagc aggaacctat ttaggtggca ccaatcttga cttccagatg    180

gaacagtaca tctataaaag gaaaagtgat ggcatctaca tcataaatct gaagcggacc    240

tgggagaagc ttctgctggc agctcgtgcc attgttgcca ttgaaaaccc tgctgatgtc    300

agtgttatat cttccaggaa tactggccag agggccgtgc tgaagtttgc tgctgccact    360

ggagccactc caattgctgg ctgcttcact cctggaactg tccgtcgcta accagatcca    420

ggcagccttc tgggacccac ggcttcttgt ggttactgac cccagggctg accaccagcc    480

tctcatggag gcatcttctg ttaacctacc taccattgct ctgtgtaaca cagattctcc    540

tctgtgctat gtggacattg ccatcccatg caacaacaag ggagctcact cagtgggttt    600

gatgtggtgg atgctggctc gggaagttct gcgcatgcgt ggcaccattt cccatgaaca    660

cccatgggag gtcatgcctg atctctactt ctacagggat cctgaagaga ttgaaaaaga    720

agagcaggct gctgctgaaa aggtaatgac caaggaggaa tttcagggtg aatggactgc    780

tccagctcct gagttcactg ctactcagct tgaggttgca gactggtctg aaggtgtgcg    840

ggtgccctct gtgcctattc agcagttccc tgttgaagac tggagcgctc agcctgccac    900

ggaagactgg tctgcagctc ccactgctca ggccactgaa cgggtaggag caaccactga    960

atggtcttaa gctgttcttg catgggctct taagcaacat ggaaaaatgg ttgatggaaa   1020

ataaacatca gtttcttaaa                                               1040


<210>  1347
<211>  9629
<212>  DNA
<213>  Homo sapiens

<400>  1347
agtagtttgc ggcatccgga ggagcagcag cagcagtagc ggcggcggct ggcgcagcgc     60

ggagacggac gagcgggcac agacggcagc acagctcccg tgcaccatgc ctggcttgcc    120

cgggaggcac tggcacccgc gtccctagcc cggcgctggc ccttggcgcg ttgcgctccg    180

cagcattccg gctgagcgat ttcatccgaa atcctaaacc tcctacccca aacccattgc    240

ctcctgcttg ctcatactcc acactcacac tccccacacc acacactcac tcttcctctc    300

tctctcacac attcacacac agcccgagac agacagagaa agcgagacag acctcccgag    360

tgcgcgagcg cccgggagga agggagccca acgcagcgcg gccagcgcct ctccgggaag    420

atgaaatcaa gacgctcctg caagtaaact tcggcggcga caaaatcgtc gactgtggca    480

gctgctgagg cggaccccag cgacgtgcaa ctgagctagg agggcttcct cccgcggcgg    540

cggcggcggc ggcggcggcg gcggaccttg gagcgacacc ccagcccaaa cggagagaag    600

agaagcaccc ggtacccacg gcggcggccc cgcctctcct ggccggtact gttgttgcct    660

ccccttccct cttccccatt ccccgccacc cccggccatt agaaagaccg gggctttgat    720

tttcttggac aaattgccat ctccccgttt ccacaaactt gacgtggagg gtcggactgc    780

gttgttaact ttgatttcct agacgaaaac gcccgcagac cctcaactgc tctgtggggg    840

gaactccgct cccacctcgg atcctggaca gacgcgcccc caagcccttc gaagccagcc    900

ttagcgcgag ggagcgcgct caagctctgg cagcctctct cccctccccc ttcctctgct    960

ggccccggga ccgccatccg actcaaccct ataaccgggt gcccgcggcg cttgccagta   1020

actgactccc gtctgcgaca ccccctttct cccgaacagg cctcgaagag gccagtgtgg   1080

cccccccaga ccccggaggg cgcattccaa gcgggtactc tctccgcagt gaactgggag   1140

cgctgggggg aggtctttgc gcatgccagg tgcacagaca gcgagttcgc cagcctcagt   1200

gccggtgcac cgcggcgggc cgggcagtgc ctgaaaggct gcgcctcctc cgccctcttt   1260

accttcgcct caagtactgt ccggactcag cggtgcgtcc tccaggccgc gcagacgccg   1320

cccgacccgc agccctgggc ggctgccgac agtcgcgccc ggctaacttt gaaggggtaa   1380

aactgagtag ccgggctgga gggagggggc tcggggccgc gcggcgctcc cttggcccct   1440

cggagccccc ggggcccccg cgagcccccg ccgcgtccgc cgcaacctca gcattggagc   1500

cgccgcgggt gtcccccgcg cgccgccggg ccgccctggg cgggacttct cccgcggcct   1560

ccggggccac ggggcgcgcg caacaggcgg cccgagccgg cgggaagctg gagcgccgac   1620

ggcgtcggtc tcggaggggt gtggagaggc gaggccaggc agagccccgt gcagccatgg   1680

agtcgctcct gctgccggtg ctgctgctgc tggccatact gtggacgcag gctgccgccc   1740

tcattaatct caagtactcg gtagaagagg agcagcgcgc cgggacggtg attgccaacg   1800

tggccaaaga cgcgcgagag gcgggcttcg cgctggaccc ccggcaggct tcagcctttc   1860

gcgtggtgtc caactcggct ccacacctag tggacatcaa tcccagctct ggcctgctgg   1920

tcaccaagca gaagattgac cgtgatctgc tgtgccgcca gagccccaag tgcatcatct   1980

cgctcgaggt catgtccagc tcaatggaaa tctgcgtgat aaaggtggag atcaaggacc   2040

tgaacgacaa tgcgcccagt ttcccggcag cacagatcga gctggagatc tcggaggcag   2100

ccagccctgg cacgcgcatc ccgctggaca gcgcttacga tccagactca ggaagctttg   2160

gcgtgcagac ttacgagctc acgcccaacg agctgttcgg cctggagatc aagacgcgcg   2220

gcgacggctc ccgctttgcc gaactcgtgg tggaaaagag cctggaccgc gagacgcagt   2280

cgcactacag cttccgaatc actgcgctag acggtggcga cccgccgcgc ctgggcaccg   2340

ttggccttag tatcaaggtg accgactcca atgacaacaa cccggtgttt agcgagtcca   2400

cctacgcggt gagcgtgcca gaaaactcgc ctcccaacac acccgtcatc cgcctcaacg   2460

ccagcgatcc agacgagggc accaacggcc aggtggtcta ctccttctat ggctacgtca   2520

acgaccgcac gcgcgagctc tttcagatcg acccgcacag tggcctggtc actgtcactg   2580

gcgctttaga ctacgaagag gggcacgtgt acgaactgga cgtgcaggct aaggacttgg   2640

ggcccaattc catcccggca cactgcaagg tcaccgtcag cgtgctggac accaatgaca   2700

atccgccggt catcaacctg ctgtcagtca acagtgagct tgtggaggtc agcgagagcg   2760

cccccccggg ctacgtgatc gccttggtgc gggtgtctga tcgcgactca ggcctcaatg   2820

gacgtgtgca gtgccgtttg ctgggcaatg tgccctttcg actgcaggaa tatgagagct   2880

tctccactat tctggtggac ggacggctgg accgcgagca gcacgaccaa tacaacctca   2940

caattcaggc acgcgacggc ggcgtgccca tgctgcagag tgccaagtcc tttaccgtgc   3000

tcatcactga cgaaaatgac aaccacccgc acttttccaa gccctactac caggtcattg   3060

tgcaggagaa caacacgcct ggcgcctatc tgctctctgt gtctgctcgc gaccccgacc   3120

tgggtctcaa cggcagtgtc tcctaccaga tcgtgccgtc gcaggtgcgg gacatgcctg   3180

tcttcaccta tgtctccatc aatcccaact caggcgacat ctacgcgctg cgatccttta   3240

accacgagca gaccaaggcg ttcgaattca aggtgctggc caaggacggc ggccttccct   3300

cactgcaaag caacgctacg gtgcgggtca tcatcctcga cgtcaacgac aacaccccgg   3360

tcatcacagc cccacctctg attaacggca ctgccgaggt ctacataccc cgcaactctg   3420

gcataggcta cctggtgact gttgtcaagg cagaagacta cgatgagggc gaaaatggcc   3480

gagtcaccta cgacatgacc gagggcgacc gcggcttctt tgaaatagac caggtcaatg   3540

gcgaagtcag aaccacccgc accttcgggg agagctccaa gtcctcctat gagcttatcg   3600

tggtggctca cgaccacggc aagacatctc tctctgcctc tgctctcgtc ctaatctact   3660

tgtcccctgc tctcgatgcc caagagtcaa tgggctctgt gaacttgtcc ttgattttca   3720

ttattgccct gggctccatt gcgggcatcc tctttgtaac tatgatcttc gtggcaatca   3780

agtgcaagcg agacaacaaa gagatccgga cctacaactg cagaattgct gagtactcct   3840

atgggcatca aaagaaatca agcaagaaga aaaaaatcag taagaatgac atccgcctgg   3900

taccccggga tgtggaggag acagacaaga tgaacgttgt cagttgctct tccctgacct   3960

cctccctcaa ctattttgac taccaccagc agacgctgcc cctgggctgc cgccgctctg   4020

agagcacttt cctgaatgtg gagaaccaga atacccgcaa caccagtgct aaccacatct   4080

accatcactc tttcaacagc caggggcccc agcagcctga cctgattatc aacggtgtgc   4140

ctctgcctga gactgaaaac tattcttttg actccaacta cgtgaatagc cgagcccatt   4200

taatcaagag ctccaccttc aaggacttag agggcaacag cctgaaggat agtggacatg   4260

aggagagtga ccaaactgac agtgagcatg atgtccagcg gagcctgtat tgtgatactg   4320

ctgtcaacga tgtgctgaac accagtgtga cctccatggg atctcagatg cctgatcatg   4380

atcagaatga aggatttcat tgccgggaag aatgccggat tcttggccac tctgacaggt   4440

gctggatgcc ccggaacccc atgcccatcc gttccaagtc ccctgagcat gtgaggaaca   4500

tcatcgcgct gtctattgaa gctactgctg ctgatgtcga ggcttatgac gactgcggcc   4560

ccaccaaacg gactttcgca acctttggga aagatgtcag cgaccacccg gctgaggaga   4620

ggcctaccct gaaaggcaag aggactgtcg atgtgaccat ctgcagcccc aaggtcaaca   4680

gcgttatccg ggaggcaggc aatggctgtg aggcgattag ccctgtcacc tcccccctcc   4740

acctcaagag ctctctgccc accaagcctt ccgtgtctta caccattgcc ctggctcccc   4800

cagcccgtga tctggagcag tatgtcaaca atgtcaacaa tggccctact cgtccctctg   4860

aagctgagcc ccgtggagct gatagcgaga aagtcatgca tgaggtcagc cccattctga   4920

aggaaggtcg caacaaagag tcccctggtg tgaagcgtct gaaggatatc gttctctaaa   4980

ccagtctcca ggaagaagag aaagaaacca cactggctag tgaagaagca ggagcttctt   5040

gttttaattg ctcaccaatg gttggttctt gagtggctat atttcagagc ttttcctaaa   5100

tgtattgttt ataggtgatt atcattctgt gacagtccct tgtttcaaca ggcagcaggg   5160

gtgttcagtt ggagcaaatt agctttggct tgagttgttc atggggcctt gatgttgggg   5220

aaacagagac aaattcagtt gtgaaaagta ttatgtatta agtgtttgaa tttatatatt   5280

tttctatgtc aaaattataa tataaattac cattgtttgt ggaggattac atttaaaaaa   5340

gcaaaaagtg aaaaaaaaaa gctctggaca cctttaataa gctcgccact gttttttgta   5400

gtgtagacaa gttaatggtc atttattgtg tactattcat tgattcagtg atgtgaaatt   5460

gagcccccaa aaggttgttt ctgaagctcg agtacttccc aatgccgcta ctttgctgtg   5520

gacacccctg ctttaaaaac ccttttgcta gctgtgctat tgttgtattt gatattgcaa   5580

attgctatgt gtgtggtgat ggcaaaaggc ttttaaaagt tggtgttttc tttttcttaa   5640

aaaaataata aaactacaga caaaaacaaa gtgcaaacaa ctgagacagc aaatgaatga   5700

gcaacaccat gcatatagat tgagtacttg gagaatactc acgtttttta actcatgtag   5760

tgattgctca ccactttgca aagtattttt cctgcctttc agtggtctgc ccaggtccat   5820

gatagatcat tgcagaaagt catttttgga taggctgcta tctaatttgc agttgtcaga   5880

aatactgtgc tgaaagtttt atgacatcca tcttttaaat tttcaggccc tgaacaggaa   5940

agttgctcct gaagttatgt ttccaggctt agaaattccc tctctccaat catctaaaat   6000

tgaagatgac tgaatctatt ttaagatcta aattagcatc tcttcagaca cacacttcct   6060

gattcagtgt ttcccaatca tgattagaat tagactgcaa agcacgtcat gggctgggat   6120

tgagaactcc atgttgctct gtatcttagg cttatatacg tagggataga gtaagcagta   6180

caaagtgtat attttggaaa agacaggtaa caggtaacag catcgctaat ccaattactg   6240

tgccttctaa acggagacac tcagacactt gaactcatct ttttatgact aatagttttt   6300

tgattaaaaa tgtgaacaag aaaatactaa aataaaaatc ctttcgattt agccaactct   6360

ttttgctgta ggctaggaat acaccctttt taaattaaca cactgtagat cctttttttc   6420

tgttttaaca ttcctctaac tcccccattt atcttttgtc tattaatatt cactagccaa   6480

catagtattt ttgcagccta agagttcatt atttaaaaat aaactaaaga aatatgtcac   6540

ctttgttctg ccttggtctt aagagagttg tttctagaga aacaagtttt atggttctgt   6600

tttcatttgt ttcatttttt gaaattcagg aatacacaga gagaaggcct agaggttaga   6660

gcactagaat gcaaaagagg atttattttc ttaagtttag gtagataagt cagctctttt   6720

gaatgtttta cttatttttg cctgagttcc tagctttacg cattactagg aatattttct   6780

tttacaggag ggagaagggt tttgagggag ggggtgggta aggcagtagg gatggggtta   6840

ggtaggggag aacatttctg aaaaagaact tataatgaag ctacaaatcc atccttattt   6900

cttattcagt gctgaatact acctcatgca aaatattggt gtggctgcaa atttccctct   6960

gaagctgaca caattaagga tgaattacca taacatcttc atttttcctc atttcattgc   7020

ctctcataca gttttctccc tctgatttat ttcattttgg tagtggattt tgaattaagt   7080

atttatttct ctttgcaagt gactatttga ttaacacatt aaaaattttt taaaaatttc   7140

ccctttaagt tatgatggct gcctatagaa tttagactgt ttctcaccct gatccatcct   7200

gatattatgt tattagctac gatttcaagg tcactttgaa gtcagacttc acagttttct   7260

acaggtgtat ttcttgctat gctcagtggg aaccagggag cagaaaagat tgtggaaagt   7320

gggaacatta attgtcacgt ggctgttgag ccagagaggc cactggctgc catgcctctt   7380

accagccaag ttttaaatgg ttagagtggc attggcattg attttgcttt tctcttgggt   7440

tttcttcatt tcttttcata attcatcttc aagctataga tccatccttc ttccctatcc   7500

aaatactttg ttctcagtgg gcagtcagat ttttttggct tccaaacctc actgagcatg   7560

ttcagagaat tcctctcatt aaggaaatat ttttccccac aattgtctga tgtatgagtc   7620

ctctcagaag cacaagtgca tactaggaag gctttgtaaa ctggttttgt aggcaggctg   7680

tacctgcaaa taggcattct gagcaaggat cctaaatttc cctttggctc atgtcccccc   7740

cgccccaccc caccttctcc tttttggcat gtctggtgaa aagctacaag gttcacaggg   7800

ccaaatattc tcccttttgt tctctaaaca tgttgcacac ataaactcaa gggagtgatt   7860

tcggttccta agtcctaggg agttctattc catttattct gatgtccctt ttaaggagga   7920

gttggtgttg aagtgtgaca tgctttaatg ataactgctt tggcaattcc ccagacaggt   7980

atacttcttc atccaaaatt gcacctaagg tgttcattta gacaaaattg ttcgcttagt   8040

gatccactga tctctaatca gaaatatttt taaaaaatac aatttagatc tctgaaaatt   8100

ggaaccactc aagagtatca tcttgatagt gttacttcag catatgactg actgatttta   8160

tgaagggagt ttagctgact tttccctgta gccctatcat attaaaaaca aaaagtggtc   8220

cacttgaagc agcaaggaca aagggcagtt tagggagagg cagggtgaag gggatagctc   8280

gattgggcat ccagagtgga aaaggattat tattgtacat aatagcagtt ctggctggaa   8340

ttccaatcca ctttctgggg atcattttga tgttgaatgt tcccccaaag cattctgaca   8400

agtttggtcc acttggctct ttaccccggg taataagacc cttattgact ttgaaaaact   8460

ggcataaatg agcttaagaa atccattgta tacagtccta gtgtttgcct tcttggtaaa   8520

attacattta aggatgtcat ttcatgagtc aaattgtatc tgctgacact gaagtgtatt   8580

gagatgttgt tctttagttt aagtatgtaa caaagtaata ttcaaagggg atgtttgggg   8640

gtggggctgg gaccgggtgg ctttatattg ataatgaaat attccagagc aaaacacatt   8700

gtcctaatga agttgttgca gctctcttcg ttttcttgtg ccgctggaat tggcttgtgg   8760

gtcacttgtt gtgcaaaagt gaattaattt caaataggaa tcatattgct tttgtgaaac   8820

aaagaaaatt taccaccttg tctgatacat agattggaag gcgctcttgg taaagaataa   8880

cccacaaaca cctgatcttg attggaaagc attgtaggtc attagggaaa actgatgatg   8940

ctgactgttg ctccagctgt gttggcaatt caagatgacc ttgttactaa ctgaaagttg   9000

ctgtcaacct tagcaaacaa accagctaac accattacag cactggttaa gtagattttt   9060

actggcactg gctggcgttc agctgaggaa ggctaggata cagactttaa tgaccaagag   9120

ccagactagc tcgagctaga aatcagcaac aaatacctcc ttgtgctatt tgaatgctaa   9180

ggtattagtt gcaataggct tacgccttcg ctcctctagt gaggggaatg agcctgatga   9240

cactattact gtttacctgt caaaccaggg tggaaattta gagggatgca agtacagtat   9300

gtctcattaa gcagtctctg ttgctgatta tatgaagata aaattgttgt atatgctgat   9360

ctgtatgtta tgtacatttt cacagtgatt gaatcattgt aaaaagaaaa aagacaaaaa   9420

agaatcacca ctgtctattt tatgaagatg ataaagcagc tttattaaat tattacagtt   9480

atgtttcaaa tggtgttatc tgccacattg tttcctttta tctggtggtt ctctgtttcc   9540

ccctttaaat gtgttttctc tgcttcaaaa atttaatgca ttttagtatt aaaggctatt   9600

atggaaaaag taaaaaaaaa aaaaaaaaa                                     9629


<210>  1348
<211>  1100
<212>  PRT
<213>  Homo sapiens

<400>  1348

Met Glu Ser Leu Leu Leu Pro Val Leu Leu Leu Leu Ala Ile Leu Trp 
1               5                   10                  15


Thr Gln Ala Ala Ala Leu Ile Asn Leu Lys Tyr Ser Val Glu Glu Glu 
            20                  25                  30


Gln Arg Ala Gly Thr Val Ile Ala Asn Val Ala Lys Asp Ala Arg Glu 
        35                  40                  45


Ala Gly Phe Ala Leu Asp Pro Arg Gln Ala Ser Ala Phe Arg Val Val 
    50                  55                  60


Ser Asn Ser Ala Pro His Leu Val Asp Ile Asn Pro Ser Ser Gly Leu 
65                  70                  75                  80


Leu Val Thr Lys Gln Lys Ile Asp Arg Asp Leu Leu Cys Arg Gln Ser 
                85                  90                  95


Pro Lys Cys Ile Ile Ser Leu Glu Val Met Ser Ser Ser Met Glu Ile 
            100                 105                 110


Cys Val Ile Lys Val Glu Ile Lys Asp Leu Asn Asp Asn Ala Pro Ser 
        115                 120                 125


Phe Pro Ala Ala Gln Ile Glu Leu Glu Ile Ser Glu Ala Ala Ser Pro 
    130                 135                 140


Gly Thr Arg Ile Pro Leu Asp Ser Ala Tyr Asp Pro Asp Ser Gly Ser 
145                 150                 155                 160


Phe Gly Val Gln Thr Tyr Glu Leu Thr Pro Asn Glu Leu Phe Gly Leu 
                165                 170                 175


Glu Ile Lys Thr Arg Gly Asp Gly Ser Arg Phe Ala Glu Leu Val Val 
            180                 185                 190


Glu Lys Ser Leu Asp Arg Glu Thr Gln Ser His Tyr Ser Phe Arg Ile 
        195                 200                 205


Thr Ala Leu Asp Gly Gly Asp Pro Pro Arg Leu Gly Thr Val Gly Leu 
    210                 215                 220


Ser Ile Lys Val Thr Asp Ser Asn Asp Asn Asn Pro Val Phe Ser Glu 
225                 230                 235                 240


Ser Thr Tyr Ala Val Ser Val Pro Glu Asn Ser Pro Pro Asn Thr Pro 
                245                 250                 255


Val Ile Arg Leu Asn Ala Ser Asp Pro Asp Glu Gly Thr Asn Gly Gln 
            260                 265                 270


Val Val Tyr Ser Phe Tyr Gly Tyr Val Asn Asp Arg Thr Arg Glu Leu 
        275                 280                 285


Phe Gln Ile Asp Pro His Ser Gly Leu Val Thr Val Thr Gly Ala Leu 
    290                 295                 300


Asp Tyr Glu Glu Gly His Val Tyr Glu Leu Asp Val Gln Ala Lys Asp 
305                 310                 315                 320


Leu Gly Pro Asn Ser Ile Pro Ala His Cys Lys Val Thr Val Ser Val 
                325                 330                 335


Leu Asp Thr Asn Asp Asn Pro Pro Val Ile Asn Leu Leu Ser Val Asn 
            340                 345                 350


Ser Glu Leu Val Glu Val Ser Glu Ser Ala Pro Pro Gly Tyr Val Ile 
        355                 360                 365


Ala Leu Val Arg Val Ser Asp Arg Asp Ser Gly Leu Asn Gly Arg Val 
    370                 375                 380


Gln Cys Arg Leu Leu Gly Asn Val Pro Phe Arg Leu Gln Glu Tyr Glu 
385                 390                 395                 400


Ser Phe Ser Thr Ile Leu Val Asp Gly Arg Leu Asp Arg Glu Gln His 
                405                 410                 415


Asp Gln Tyr Asn Leu Thr Ile Gln Ala Arg Asp Gly Gly Val Pro Met 
            420                 425                 430


Leu Gln Ser Ala Lys Ser Phe Thr Val Leu Ile Thr Asp Glu Asn Asp 
        435                 440                 445


Asn His Pro His Phe Ser Lys Pro Tyr Tyr Gln Val Ile Val Gln Glu 
    450                 455                 460


Asn Asn Thr Pro Gly Ala Tyr Leu Leu Ser Val Ser Ala Arg Asp Pro 
465                 470                 475                 480


Asp Leu Gly Leu Asn Gly Ser Val Ser Tyr Gln Ile Val Pro Ser Gln 
                485                 490                 495


Val Arg Asp Met Pro Val Phe Thr Tyr Val Ser Ile Asn Pro Asn Ser 
            500                 505                 510


Gly Asp Ile Tyr Ala Leu Arg Ser Phe Asn His Glu Gln Thr Lys Ala 
        515                 520                 525


Phe Glu Phe Lys Val Leu Ala Lys Asp Gly Gly Leu Pro Ser Leu Gln 
    530                 535                 540


Ser Asn Ala Thr Val Arg Val Ile Ile Leu Asp Val Asn Asp Asn Thr 
545                 550                 555                 560


Pro Val Ile Thr Ala Pro Pro Leu Ile Asn Gly Thr Ala Glu Val Tyr 
                565                 570                 575


Ile Pro Arg Asn Ser Gly Ile Gly Tyr Leu Val Thr Val Val Lys Ala 
            580                 585                 590


Glu Asp Tyr Asp Glu Gly Glu Asn Gly Arg Val Thr Tyr Asp Met Thr 
        595                 600                 605


Glu Gly Asp Arg Gly Phe Phe Glu Ile Asp Gln Val Asn Gly Glu Val 
    610                 615                 620


Arg Thr Thr Arg Thr Phe Gly Glu Ser Ser Lys Ser Ser Tyr Glu Leu 
625                 630                 635                 640


Ile Val Val Ala His Asp His Gly Lys Thr Ser Leu Ser Ala Ser Ala 
                645                 650                 655


Leu Val Leu Ile Tyr Leu Ser Pro Ala Leu Asp Ala Gln Glu Ser Met 
            660                 665                 670


Gly Ser Val Asn Leu Ser Leu Ile Phe Ile Ile Ala Leu Gly Ser Ile 
        675                 680                 685


Ala Gly Ile Leu Phe Val Thr Met Ile Phe Val Ala Ile Lys Cys Lys 
    690                 695                 700


Arg Asp Asn Lys Glu Ile Arg Thr Tyr Asn Cys Arg Ile Ala Glu Tyr 
705                 710                 715                 720


Ser Tyr Gly His Gln Lys Lys Ser Ser Lys Lys Lys Lys Ile Ser Lys 
                725                 730                 735


Asn Asp Ile Arg Leu Val Pro Arg Asp Val Glu Glu Thr Asp Lys Met 
            740                 745                 750


Asn Val Val Ser Cys Ser Ser Leu Thr Ser Ser Leu Asn Tyr Phe Asp 
        755                 760                 765


Tyr His Gln Gln Thr Leu Pro Leu Gly Cys Arg Arg Ser Glu Ser Thr 
    770                 775                 780


Phe Leu Asn Val Glu Asn Gln Asn Thr Arg Asn Thr Ser Ala Asn His 
785                 790                 795                 800


Ile Tyr His His Ser Phe Asn Ser Gln Gly Pro Gln Gln Pro Asp Leu 
                805                 810                 815


Ile Ile Asn Gly Val Pro Leu Pro Glu Thr Glu Asn Tyr Ser Phe Asp 
            820                 825                 830


Ser Asn Tyr Val Asn Ser Arg Ala His Leu Ile Lys Ser Ser Thr Phe 
        835                 840                 845


Lys Asp Leu Glu Gly Asn Ser Leu Lys Asp Ser Gly His Glu Glu Ser 
    850                 855                 860


Asp Gln Thr Asp Ser Glu His Asp Val Gln Arg Ser Leu Tyr Cys Asp 
865                 870                 875                 880


Thr Ala Val Asn Asp Val Leu Asn Thr Ser Val Thr Ser Met Gly Ser 
                885                 890                 895


Gln Met Pro Asp His Asp Gln Asn Glu Gly Phe His Cys Arg Glu Glu 
            900                 905                 910


Cys Arg Ile Leu Gly His Ser Asp Arg Cys Trp Met Pro Arg Asn Pro 
        915                 920                 925


Met Pro Ile Arg Ser Lys Ser Pro Glu His Val Arg Asn Ile Ile Ala 
    930                 935                 940


Leu Ser Ile Glu Ala Thr Ala Ala Asp Val Glu Ala Tyr Asp Asp Cys 
945                 950                 955                 960


Gly Pro Thr Lys Arg Thr Phe Ala Thr Phe Gly Lys Asp Val Ser Asp 
                965                 970                 975


His Pro Ala Glu Glu Arg Pro Thr Leu Lys Gly Lys Arg Thr Val Asp 
            980                 985                 990


Val Thr Ile Cys Ser Pro Lys Val Asn Ser Val Ile Arg Glu Ala Gly 
        995                 1000                1005


Asn Gly Cys Glu Ala Ile Ser Pro Val Thr Ser Pro Leu His Leu Lys 
    1010                1015                1020


Ser Ser Leu Pro Thr Lys Pro Ser Val Ser Tyr Thr Ile Ala Leu Ala 
1025                1030                1035                1040


Pro Pro Ala Arg Asp Leu Glu Gln Tyr Val Asn Asn Val Asn Asn Gly 
                1045                1050                1055


Pro Thr Arg Pro Ser Glu Ala Glu Pro Arg Gly Ala Asp Ser Glu Lys 
            1060                1065                1070


Val Met His Glu Val Ser Pro Ile Leu Lys Glu Gly Arg Asn Lys Glu 
        1075                1080                1085


Ser Pro Gly Val Lys Arg Leu Lys Asp Ile Val Leu 
    1090                1095                1100


<210>  1349
<211>  3568
<212>  DNA
<213>  Homo sapiens

<400>  1349
atagttttca ggttaagaaa gccagaatct ttgttcagcc acactgactg aacagacttt     60

tagtggggtt acctggctaa cagcagcagc ggcaacggca gcagcagcag cagcagcagc    120

agcagcagca gcagggctcc tgggataact caggcatagt tcaacactat gggtcctcct    180

ctgaagctct tcaaaaacca gaaataccag gaactgaagc aggaatgcat caaagacagc    240

agacttttct gtgatccaac atttctgcct gagaatgatt ctcttttcta caaccgactg    300

cttcctggaa aggtggtgtg gaaacgtccc caggacatct gtgatgaccc ccatctgatt    360

gtgggcaaca ttagcaacca ccagctgacc caagggagac tggggcacaa gccaatggtt    420

tctgcatttt cctgtttggc tgttcaggag tctcattgga caaagacaat tcccaaccat    480

aaggaacagg aatgggaccc tcaaaaaaca gaaaaatacg ctgggatatt tcactttcgt    540

ttctggcatt ttggagaatg gactgaagtg gtgattgatg acttgttgcc caccattaac    600

ggagatctgg tcttctcttt ctccacttcc atgaatgagt tttggaatgc tctgctggaa    660

aaagcttatg caaagctgct aggctgttat gaggccctgg atggtttgac catcactgat    720

attattgtgg acttcacggg cacattggct gaaactgttg acatgcagaa aggaagatac    780

actgagcttg ttgaggagaa gtacaagcta ttcggagaac tgtacaaaac atttaccaaa    840

ggtggtctga tctgctgttc cattgagtct cccaatcagg aggagcaaga agttgaaact    900

gattggggtc tgctgaaggg ccatacctat accatgactg atattcgcaa aattcgtctt    960

ggagagagac ttgtggaagt cttcagtgct gagaaggtgt atatggttcg cctgagaaac   1020

cccttgggaa gacaggaatg gagtggcccc tggagtgaaa tttctgaaga gtggcagcaa   1080

ctgactgcat cagatcgcaa gaacctgggg cttgttatgt ctgatgatgg agagttttgg   1140

atgagcttgg aggacttttg ccgcaacttt cacaaactga atgtctgccg caatgtgaac   1200

aaccctattt ttggccgaaa ggagctggaa tcggtgttgg gatgctggac tgtggatgat   1260

gatcccctga tgaaccgctc aggaggctgc tataacaacc gtgatacctt cctgcagaat   1320

ccccagtaca tcttcactgt gcctgaggat gggcacaagg tcattatgtc actgcagcag   1380

aaggacctgc gcacttaccg ccgaatggga agacctgaca attacatcat tggctttgag   1440

ctcttcaagg tggagatgaa ccgcaaattc cgcctccacc acctctacat ccaggagcgt   1500

gctgggactt ccacctatat tgacacccgc acagtgtttc tgagcaagta cctgaagaag   1560

ggcaactatg tgcttgtccc aaccatgttc cagcatggtc gcaccagcga gtttctcctg   1620

agaatcttct ctgaagtgcc tgtccagctc agggaactga ctctggacat gcccaaaatg   1680

tcctgctgga acctggctcg tggctacccg aaagtagtta ctcagatcac tgttcacagt   1740

gctgaggacc tggagaagaa gtatgccaat gaaactgtaa acccatattt ggtcatcaaa   1800

tgtggaaagg aggaagtccg ttctcctgtc cagaagaata cagttcatgc catttttgac   1860

acccaggcca ttttctacag aaggaccact gacattccta ttatagtaca ggtctggaac   1920

agccgaaaat tctgtgatca gttcttgggg caggttactc tggatgctga ccccagcgac   1980

tgccgtgatc tgaagtctct gtacctgcgt aagaagggtg gtccaactgc caaagtcaag   2040

caaggccaca tcagcttcaa ggttatttcc agcgatgatc tcactgagct ctaaatctgc   2100

aatcccagag aatcctgaca aagcgtgcca cccttttatt ttccgtcagg tgccaggtct   2160

tagttaagat tcacaatctt tagaaagaat gagattcaca ataattaact cttcctctct   2220

tctgataaat tccccatacc tcccaatcca agtagcatct gtagctacat aacctatata   2280

cctccagcag ctggacatgg ggaggcgaca gtcctatcta gacatcatac acatttgcca   2340

agaaaggatc tctggggctt ccgggggtga gattcaagca ggacaataac aagaggctgg   2400

acaccctaca gatgtctttg atgttttcag ttgtttgata tatctcccct gtagggcatg   2460

ttgaggaagg aggagggctg atcaaggcca agctggtcta gcctgacatc ctagctcctg   2520

actgaacact atagacttcc cagcagcatt tcacccagca gccagagccg gctttaagtc   2580

cccaaccctt acagacacca ctgccaccac caccaaccac gaccaccacc accaccacca   2640

ctcaccacca tcatcacctc cggaaagtgt agtcctgccc taacccaagt cacccccgac   2700

agtaaatttt accttcatgt tgagaaagct tcctggtgct taatcaagag ctggagttca   2760

atgagtccta gacagtgaga ggggcctgag cttcagctca atggaagcct gctgtgtgcc   2820

acaagacgga aaagtggaag aagctgcagt gggagacaaa gcctcggtcc cccacccatc   2880

cacacacacc tacactcaca cacgcgcaca tgggcgcgca cgaactacca ttcaggcagt   2940

cagtgggcaa gaggaaagat aagtaagtac catacacacc taaaagatga gagaattcat   3000

ccagacatat tacagccagt ttggggcccc tgactgcaat gtgaaacctc tcgctgctgc   3060

taggtttaca aacaagccca ttgtcctgtg cctcctaata tcatttgtac tgaagacccc   3120

atctggggac ttgagacttt ggtcccagcc cagactcctc agacttttct ctcagttggg   3180

atgcttcact cgctgggggt gtttgtttgc cctctcattt ttcagtactt ctacagaatt   3240

ttctctagag tcagtcatta tgaaatgtac ttccctccat cttaacctat caactttctg   3300

cccctccttc aaggcccagt ataaatgcca cctcctccat gaagccttcc ctaattccac   3360

cccaaacccc caccttcaac aatatttcaa cgcttctgca atgatgaaaa agaaacatag   3420

ttgtagtact tagcctacct agaccagcaa gcattcattt ttagctcgct cattttttac   3480

catgttttcc agtctgttta acttctgcag tgccttcact acactgcctt acataaacca   3540

aatcacaata aagttcatat tcagtaca                                      3568


<210>  1350
<211>  641
<212>  PRT
<213>  Homo sapiens

<400>  1350

Met Gly Pro Pro Leu Lys Leu Phe Lys Asn Gln Lys Tyr Gln Glu Leu 
1               5                   10                  15


Lys Gln Glu Cys Ile Lys Asp Ser Arg Leu Phe Cys Asp Pro Thr Phe 
            20                  25                  30


Leu Pro Glu Asn Asp Ser Leu Phe Tyr Asn Arg Leu Leu Pro Gly Lys 
        35                  40                  45


Val Val Trp Lys Arg Pro Gln Asp Ile Cys Asp Asp Pro His Leu Ile 
    50                  55                  60


Val Gly Asn Ile Ser Asn His Gln Leu Thr Gln Gly Arg Leu Gly His 
65                  70                  75                  80


Lys Pro Met Val Ser Ala Phe Ser Cys Leu Ala Val Gln Glu Ser His 
                85                  90                  95


Trp Thr Lys Thr Ile Pro Asn His Lys Glu Gln Glu Trp Asp Pro Gln 
            100                 105                 110


Lys Thr Glu Lys Tyr Ala Gly Ile Phe His Phe Arg Phe Trp His Phe 
        115                 120                 125


Gly Glu Trp Thr Glu Val Val Ile Asp Asp Leu Leu Pro Thr Ile Asn 
    130                 135                 140


Gly Asp Leu Val Phe Ser Phe Ser Thr Ser Met Asn Glu Phe Trp Asn 
145                 150                 155                 160


Ala Leu Leu Glu Lys Ala Tyr Ala Lys Leu Leu Gly Cys Tyr Glu Ala 
                165                 170                 175


Leu Asp Gly Leu Thr Ile Thr Asp Ile Ile Val Asp Phe Thr Gly Thr 
            180                 185                 190


Leu Ala Glu Thr Val Asp Met Gln Lys Gly Arg Tyr Thr Glu Leu Val 
        195                 200                 205


Glu Glu Lys Tyr Lys Leu Phe Gly Glu Leu Tyr Lys Thr Phe Thr Lys 
    210                 215                 220


Gly Gly Leu Ile Cys Cys Ser Ile Glu Ser Pro Asn Gln Glu Glu Gln 
225                 230                 235                 240


Glu Val Glu Thr Asp Trp Gly Leu Leu Lys Gly His Thr Tyr Thr Met 
                245                 250                 255


Thr Asp Ile Arg Lys Ile Arg Leu Gly Glu Arg Leu Val Glu Val Phe 
            260                 265                 270


Ser Ala Glu Lys Val Tyr Met Val Arg Leu Arg Asn Pro Leu Gly Arg 
        275                 280                 285


Gln Glu Trp Ser Gly Pro Trp Ser Glu Ile Ser Glu Glu Trp Gln Gln 
    290                 295                 300


Leu Thr Ala Ser Asp Arg Lys Asn Leu Gly Leu Val Met Ser Asp Asp 
305                 310                 315                 320


Gly Glu Phe Trp Met Ser Leu Glu Asp Phe Cys Arg Asn Phe His Lys 
                325                 330                 335


Leu Asn Val Cys Arg Asn Val Asn Asn Pro Ile Phe Gly Arg Lys Glu 
            340                 345                 350


Leu Glu Ser Val Leu Gly Cys Trp Thr Val Asp Asp Asp Pro Leu Met 
        355                 360                 365


Asn Arg Ser Gly Gly Cys Tyr Asn Asn Arg Asp Thr Phe Leu Gln Asn 
    370                 375                 380


Pro Gln Tyr Ile Phe Thr Val Pro Glu Asp Gly His Lys Val Ile Met 
385                 390                 395                 400


Ser Leu Gln Gln Lys Asp Leu Arg Thr Tyr Arg Arg Met Gly Arg Pro 
                405                 410                 415


Asp Asn Tyr Ile Ile Gly Phe Glu Leu Phe Lys Val Glu Met Asn Arg 
            420                 425                 430


Lys Phe Arg Leu His His Leu Tyr Ile Gln Glu Arg Ala Gly Thr Ser 
        435                 440                 445


Thr Tyr Ile Asp Thr Arg Thr Val Phe Leu Ser Lys Tyr Leu Lys Lys 
    450                 455                 460


Gly Asn Tyr Val Leu Val Pro Thr Met Phe Gln His Gly Arg Thr Ser 
465                 470                 475                 480


Glu Phe Leu Leu Arg Ile Phe Ser Glu Val Pro Val Gln Leu Arg Glu 
                485                 490                 495


Leu Thr Leu Asp Met Pro Lys Met Ser Cys Trp Asn Leu Ala Arg Gly 
            500                 505                 510


Tyr Pro Lys Val Val Thr Gln Ile Thr Val His Ser Ala Glu Asp Leu 
        515                 520                 525


Glu Lys Lys Tyr Ala Asn Glu Thr Val Asn Pro Tyr Leu Val Ile Lys 
    530                 535                 540


Cys Gly Lys Glu Glu Val Arg Ser Pro Val Gln Lys Asn Thr Val His 
545                 550                 555                 560


Ala Ile Phe Asp Thr Gln Ala Ile Phe Tyr Arg Arg Thr Thr Asp Ile 
                565                 570                 575


Pro Ile Ile Val Gln Val Trp Asn Ser Arg Lys Phe Cys Asp Gln Phe 
            580                 585                 590


Leu Gly Gln Val Thr Leu Asp Ala Asp Pro Ser Asp Cys Arg Asp Leu 
        595                 600                 605


Lys Ser Leu Tyr Leu Arg Lys Lys Gly Gly Pro Thr Ala Lys Val Lys 
    610                 615                 620


Gln Gly His Ile Ser Phe Lys Val Ile Ser Ser Asp Asp Leu Thr Glu 
625                 630                 635                 640


Leu 



<210>  1351
<211>  9406
<212>  DNA
<213>  Homo sapiens

<400>  1351
cttatttctt atgaatgtcg gatagctgca ccagcttggt ggggaaaggg tttgatgaat     60

agcacaaaga cactggctgt tccctggagg ctgtcccttt aaaggagaat cttagtttat    120

tctgggggga ggggatgcac acattagagt aggaaagagg gcttggaata aaatgaaaac    180

actccccctt catagtcatt gtactgaaat gcaaagactg cttcctaagc tggagatgct    240

aaccttgggt agctccttct gttctcttca aggggaattt tgtcaggcta tggattcatt    300

tacaactgtt agtcatgtgg gcatgtgtga ggaaacagat gccagtttta atgtatttag    360

cccgaagttc caatttgata ggagccactg tcagtctctg aggttccacc aaaatatgga    420

acttgatttt ggacactttg acgaaagaga taagacatcc aggaacatgc gaggctcccg    480

gatgaatggg ttgcctagcc ccactcacag cgcccactgt agcttctacc gaaccagaac    540

cttgcaggca ctgagtaatg agaagaaagc caagaaggta cgtttctacc gcaatgggga    600

ccgctacttc aaggggattg tgtacgctgt gtcctctgac cgttttcgca gctttgacgc    660

cttgctggct gacctgacgc gatctctgtc tgacaacatc aacctgcctc agggagtgcg    720

ttacatttac accattgatg gatccaggaa gatcggaagc atggatgaac tggaggaagg    780

ggaaagctat gtctgttcct cagacaactt ctttaaaaag gtggagtaca ccaagaatgt    840

caatcccaac tggtctgtca acgtaaaaac atctgccaat atgaaagccc cccagtcctt    900

ggctagcagc aacagtgcac aggccaggga gaacaaggac tttgtgcgcc ccaagctggt    960

taccatcatc cgcagtgggg tgaagcctcg gaaggctgtg cgtgtgcttc tgaacaagaa   1020

gacagcccac tcttttgagc aagtcctcac tgatatcaca gaagccatca aactggagac   1080

cggggttgtc aaaaaactct acactctgga tggaaaacag gtaacttgtc tccatgattt   1140

ctttggtgat gatgatgtgt ttattgcctg tggtcctgaa aaatttcgct atgctcagga   1200

tgatttttct ctggatgaaa atgaatgccg agtcatgaag ggaaacccat cagccacagc   1260

tggcccaaag gcatccccaa cacctcagaa gacttcagcc aagagccctg gtcctatgcg   1320

ccgaagcaag tctccagctg actcagcaaa cggaacctcc agcagccagc tctctacccc   1380

caagtctaag cagtctccca tctctacgcc caccagtcct ggcagcctcc ggaagcacaa   1440

ggacctgtac ctgcctctgt ccttggatga ctcggactcg cttggtgatt ccatgtaaag   1500

gaggggagag tgctcagagt ccagagtaca aatccaagcc tatcattgta gtagggtact   1560

tctgctcaag tgtccaacag ggctattggt gctttcaagt ttttattttg ttgttgttgt   1620

tattttgaaa aacacattgt aatatgttgg gtttattttc ctgtgatttc tcctctgggc   1680

cactgatcca cagttaccaa ttatgagaga tagattgata accatccttt ggggcagcat   1740

tccagggatg caaaatgtgc tagtccatga cctttcaatg gaaagcttag gtgcctgcgt   1800

tatatttgcc ctgtctaatt ttgcccatac agtcttcctt ctgtagaggg ctgtttacat   1860

atacagcact taaaatgttt gtgtgggaaa aaaaaaactc attggcagat ccaagaatga   1920

caaacacaag tgcccctttt ctctggatct caagaatggt ggaggaccct ggaaggacag   1980

caaggcagct ccccagcctc actcttcact cctgattgag gcccgggttt gttgtccagc   2040

accaattctg gctgtcaatg gggagaaata aaccaacaac ttataattgt gacaccagat   2100

gcttaggatc ctggtgctgg gttagctaag agaatagaca gaattggaaa atactgcaga   2160

catttccgaa gagtttataa agcacagtga attcctggtc aatctctcca ctgaggcaat   2220

ttggaatcaa taagcaattg ataatagttt ggagtaaggg acttcatata cctgattcct   2280

ctagaaggct gtctaacata ccacatgatt acatgaactg tatggtatcc atctatctct   2340

gttctattga atgccttgtt aacagccaac actgaaaaca ctgtgagaat ttgttttcag   2400

gtctgacacc tttcagtctc tttttatagc aagaaatcaa tatccttttt ataaaaattc   2460

atgtctgtat ttcaggagca aactcttcag gctccttttt tataaactgg tgatttttct   2520

tttgtctaaa aaacacatga agaaaattta ccaaaaaaaa aaaaaaaagc agaagaataa   2580

tgtagtttag aaattatgct gtcactgcca aacagtaacc tccaggagaa aacaagatga   2640

atagcagagg ccaattcaat agaatcagtt ttttgatagc tttttaacag ttatgcttgc   2700

attaataatt tcaatgtgga ccagacattc taattatatt ttaaatgaaa tgttacagca   2760

tattttaagc aactcttttt atctataatc ctaatatttc atactgaaga cacagaaatc   2820

tttcacttgt ctttaacatt agaaaggatt tctctttact aaggactgat catttgaaat   2880

agttttcagt cttttgagat acaggtttat aacactgctt ttttttttct gtaatcatag   2940

cccataatgg caaagacaac taaatttaag tgaaggtcat gcatgccaat tctgtgtttg   3000

cttttagcag atatgaagat ttccttattt ctttgtaatt gtgcagatat tttgaaaggc   3060

acagcattcg aagccaagct gctgtttggc tactgaatgg cttgcagttg ttcctccact   3120

ctaaatggaa tgagcttgct gtgtgtgtgt gtggtggtgg tgggaggggg tggtgcatgt   3180

gtgtgtgtgt gtgtgcatct gcagctgctt caaaattagg aaatactaca ggacacccct   3240

gtaatggatt ggtggcaact gggtggcact gctgatgtgc actgtgtagg ggggaaccca   3300

gtggtggtgg ggtagctcag atgcccctag acaagcttca gatgtctgta gctaccagaa   3360

acattttcgg ttcaggaaaa gtgagatgat ggtagtactg gtttctggtg aaattgaaga   3420

accccaaatg atgaggatct ctttttgccc cctctccttt ttttgtagac ccattcaaaa   3480

ccattaataa gcccatttta ctaagcccct atttctttct agaagctcag ggttttctta   3540

gtgcctccca gaacattttg tagttaattg ggaaaaagtg atacttggat tagggggtgt   3600

gggcataaag aatggtggga ggcctgattt taaacttcag gccagaaccc ccaatgactc   3660

cacccatagt ctcactttag gtctcattta gtccatcacc tttattttaa gttgaggaag   3720

tggaggctgg taaagagcag gaccagagga agaatccaga tttccttatg cttgggcctc   3780

acactagctc tctgagtatt tccttgattg cggtatatgt actactagaa aataccaaat   3840

ggatatattt tctttaggat aacctttgaa ccaacaatct tcaataacaa tagtacatct   3900

tccatcttac ttttaatcga gtataaggaa atgtttcttt atggccattt tggagggagc   3960

aggggatgag gcttggcata gtccaaaatt taagtctcca ataattaatt gcattttaaa   4020

ttggcccact ttcaaggcaa ttttttttgt gtgtctgtaa ctgagctcct ccacccctgt   4080

cattcacttc caattttacc caatccaatt ttagcactca agttccattg tgttaatttc   4140

tgcacggtca acaaacatca agtcagcaag catttgccac cactccctat acttctccct   4200

ccttcttaca cacacacaca cacacacaca cacaatccat ctcttgcttg ttcctacctc   4260

ctgatttttc ttccctacag aaatagaaat agggacaaag aaggggaaaa tgtatatatt   4320

ggggctgggc tgaacaacta acttcataag tagtattaac taggggtaaa ttgagagaaa   4380

agctcctttt ctcttcactg ttttggaaag gatagccatt agcatgactg ctttgtgtcc   4440

ttatggactt tagtattagc ctagattgaa ttatagcgtt ttctagctgg aaggaacctt   4500

aagatcacat catctactcc tctactccaa atttctcatt cttcaggcca ggaaaccgag   4560

acacagaggt aaagtaattt ccccaaggtc acacagctgg ctggggcagg attgggttta   4620

caacccacat ctcctggctc ttattccagg gccttttccc actaagtagt attgccttcc   4680

attaggctcc tgagagttat ttctcagggt catgttgcat cttggagcca catgctgctg   4740

ccctgatctc agtgggaaat ccacccagca acctaataca gccccttttc cctgcattca   4800

cctggttccc atccacatgg gttgcagatg tccttgaaga gagtgaggca ttgagggcca   4860

ataggagcaa tggggtccct ggccttgtcc atctgattca ggagatcact gctccatcgt   4920

gaggagccct ctgaatagcc ccccactgaa tgcttgcctt gcccaaatgg aatggaggaa   4980

gattgatttt ctccatcagt tcaccttgtg tcatctcata atggttggtc tttccaggct   5040

gagggaaatg tttcttgttt ccagagtaga aaaagaaaga gtggaacaat agctttgttc   5100

atcctaactt tctgagatgg cttttcaaca ttttaaaaaa actagtgtgg ctaccattca   5160

ctggcaatga tttcttttag aatatgggag taagatgagc tagagaaaat aacctggtct   5220

cactgtggtt gccctcatcc acaatgtccc caaagccatc ctgctctgat gaggacaatt   5280

tccaggtata agcaaggggc tttgtgacaa aaatgtaccc tggctgatgt taaacattgg   5340

ctcctgtgtt tgcaccaaaa tagcaagctg tgtgctctat acactcttcc catcgtcttg   5400

tgtacactgc tcctgtggcc ttccacagca gaaaccaggg caaaagggtc caaacacatg   5460

gttttccttg ctgcaaggct cttcctggga actaaggggg tatttattag ttcagttcta   5520

agagacctcc ttctgggctt accccactcc tcaggtactt ctctctcctt cctccttctc   5580

ctccacagtc acaagtaacc aaggaacctg aaagtggatg tgtagctatt tgaagaaggc   5640

aaggaaccct gagattcttc tttgaatcct ctagtccaag tcttagacca gtgattggtg   5700

cttaccttga acaaaatttt gtctgtgttc ctaatccctt caatactctg ggtacaatgc   5760

tcccaatcac cctgcacatt tgattctaaa tggcttttat tttttaaaaa tccatatccc   5820

taggacaaga gaacaggatg cctatatccc caaaatgagc tccaggacac tgatgggaat   5880

gatcccaaag atcaccccac ctcagaaacg tctgtgccaa gagacttccc cagatagaaa   5940

cactgggaca gtggtttgaa cgacttcttt tatggttgtc cagtttgcta tggaaataaa   6000

aggcattgat tttttaaaaa gatgattgga acctgtcttt ggccacatag ggccacttgg   6060

atccatttcc aggccttact catatattgc cttcactgaa gggctttggc tttaagtccc   6120

agactggtct cccaagtgaa ccataagtgt tttggagctc atctggggtg aggcatgaga   6180

atgttgcccc atctatccct tcaggaaaag gtgccttccc tccctttctc ctaaagcctg   6240

gtccccagaa attgtttttg tctccaaaag tctagtatgg tctttataca cccagactct   6300

tagtgttgcg tcctgccttg tttccttgtt aaggatctat gcagacctcc cgctttggct   6360

tagctagcgt gacattggct atcatttgac aagactaact tttttttttt tttttttttg   6420

actgagtctc cctctgtcac ctaggctgga gtgcagtggc acaatcttgg ctcgctgcaa   6480

ccttcaccct tcacctccca ggtcgaagcg attctcctgc ctcagtctcc cgagtagctg   6540

ggattacagg cgtgcgccac caaatctggc tattttttta ttattattat ttttagtaga   6600

gatggggttt caccatgttg gccagactgg tcttgaactc ttggcctcaa attatctgcc   6660

cacctcggcc tcccaaagtg ctgggattac aggcatgagc caccatgccc agctgacaag   6720

actaattttt tatcccttgg tttattggct tcaacatctt ctggaatcag aggtgatttt   6780

ttcttacctt ggatgcctga gactagggga gtatagaatt ccaattggta attaaggcat   6840

ctttctgctc ctgatcagaa gggcaggtta gttgggagag gtcagatggc acaacagaag   6900

tcaccttgta agtaaggcaa agacttgaag gcattagcgt ttctcattac taggtcaata   6960

acctgaggga atcaatggct ttttgccgct ctacctcttg tgtatctctt tgacttttct   7020

ttctctgtct agtttcctct gttctcagtt tatattctat gttatcagtc tctctttcca   7080

cagtacaaac atccatcctt tctcctgtgc aattctgtct ctccctctta ttatctttat   7140

ttgtactttt tccttcctcc ctgtctaggc attgggcatg tgcctcttct tagcctgtga   7200

ttttgccttg ggactgatga taaattattt ccagattcaa tcagccctgg tcctacccca   7260

gtccaatcag aagtatgttg gtgggaatca acctgatcct ggccctttct tcttctccat   7320

tttcattcgt aatccccctc agcagatctt tacaagcagt ttccttatag ctcatgtatc   7380

tttaggtctt tgccttccaa gcactgtaca gaatactttg tggttccttt ttagtctgac   7440

attttgtgga gcagtgaagc gtgctcagag acataatcag ctgaagagaa aaaatccacc   7500

catggattta tatcagctaa atactaataa ttgattttgt ttgatgtgcc cataattttt   7560

aaagctgcaa tataatataa tgagggacca caggtaattt ctcctgtcat ttgttttggc   7620

tggatggggg tgggggagta attgcttaaa gttttaccat tacacattaa actctctata   7680

ataatcttgt ttggggcttg ctaactgttg agctgtttta actaaactgg taggcaatcg   7740

gagttgattt aaatgaaaag ataatttaac aaatctatac tataaaaaga gacatttgct   7800

taattgacat gtattttttc cttctgagtc acctaaacat ttactcttga caccaactgt   7860

tcatgatact gaatagacag tccatataag agaaattagt ggacctaaag aagccagatt   7920

gtaggtgtta atttattaaa cagagtgcaa agcccttgga aatgtcactg cttggcaata   7980

ccatatggaa tgccaaaatt tacaatgact tttctttata agttatccaa aagggatttg   8040

aacaagtaag aggttatgcc aaaatgtctc caatgtatgg tcctgtaata tattgcagct   8100

tgaagccaat gatcccttat gacttgtata caactaatgc atgttttatt gaattttgca   8160

tttcccacgt gtggtaagtt ctttaaaatg tttttgatca cctttttgtg ccattaaact   8220

tgtacagaaa atgtttttat ggccattttc aaagggagaa agtttaaaat ggaaacagcc   8280

caccctttct gccctatagc tgtagttaga attgagtacc tgtagcaaaa cagctgtaat   8340

tggtggttgt agtgttagag gtgttagctt gctagtgact agctttggag agtaaatgca   8400

tggtattgta catcacattt cttaactcgt tttaacctct gaaaagaata tattcttctt   8460

tgtagtcctt cttcccaccc ccttgccctc tccctctccc tgctcccagt tgtcttacag   8520

ttgtaaatat ctgatttgag gcccaataac tcttgccaag taaagtcagc aaacaacaaa   8580

caaaccaaaa tgtggggaaa aggcatttct caaccatctc tcagcagtta ttgatcattt   8640

cttaaggaac agcattgtga tcaaagactc aactttacgt aaaaatcagt ggtaaattgg   8700

ggttgtattt ggccatttga ttacatttca ggattgaata gttttcagaa tcacatgtaa   8760

tccaaagaca gtaggtagtg atgtccctta tccctgcagc tgttttaaga tagagacctc   8820

agaagactct gcttgaccga tgaccaataa ttatttgaaa aaaaaagaaa aaatgagaga   8880

aataaaacag atatttaaga actttagcca cctatttaga atagttatag ccagaaaaaa   8940

aaacaagggc atgagttcaa atgcattact atcagtgtcc taggcaatac ctaacctact   9000

ctgaaattgt gattcaaaag cagtatttca agaggcattc tccttttttg gtttgctgac   9060

cccacttgga ctggtaggtt tggtgaggcc cccataaacc agctggagca gacccttttc   9120

atctcctgtg cctgtaacac ccctcttccc ccaccccctc cgcaattcaa tgagggcttt   9180

cttgggtcag aggacttcaa ggttgtctag agaagtttgc catgtgtgta aggtgctgtg   9240

aactgtgagt gctgaagatt cgcagcattc aataccaggc agccaaagag ctgctcttgc   9300

aattattttg gctctcaagc tctgttcttc atcgcattct catttctgtg tacatttgca   9360

agatgtgtgt aatgtcattt tccaaaaata aaatttgatt tcaata                  9406


<210>  1352
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  1352

Met Lys Thr Leu Pro Leu His Ser His Cys Thr Glu Met Gln Arg Leu 
1               5                   10                  15


Leu Pro Lys Leu Glu Met Leu Thr Leu Gly Ser Ser Phe Cys Ser Leu 
            20                  25                  30


Gln Gly Glu Phe Cys Gln Ala Met Asp Ser Phe Thr Thr Val Ser His 
        35                  40                  45


Val Gly Met Cys Glu Glu Thr Asp Ala Ser Phe Asn Val Phe Ser Pro 
    50                  55                  60


Lys Phe Gln Phe Asp Arg Ser His Cys Gln Ser Leu Arg Phe His Gln 
65                  70                  75                  80


Asn Met Glu Leu Asp Phe Gly His Phe Asp Glu Arg Asp Lys Thr Ser 
                85                  90                  95


Arg Asn Met Arg Gly Ser Arg Met Asn Gly Leu Pro Ser Pro Thr His 
            100                 105                 110


Ser Ala His Cys Ser Phe Tyr Arg Thr Arg Thr Leu Gln Ala Leu Ser 
        115                 120                 125


Asn Glu Lys Lys Ala Lys Lys Val Arg Phe Tyr Arg Asn Gly Asp Arg 
    130                 135                 140


Tyr Phe Lys Gly Ile Val Tyr Ala Val Ser Ser Asp Arg Phe Arg Ser 
145                 150                 155                 160


Phe Asp Ala Leu Leu Ala Asp Leu Thr Arg Ser Leu Ser Asp Asn Ile 
                165                 170                 175


Asn Leu Pro Gln Gly Val Arg Tyr Ile Tyr Thr Ile Asp Gly Ser Arg 
            180                 185                 190


Lys Ile Gly Ser Met Asp Glu Leu Glu Glu Gly Glu Ser Tyr Val Cys 
        195                 200                 205


Ser Ser Asp Asn Phe Phe Lys Lys Val Glu Tyr Thr Lys Asn Val Asn 
    210                 215                 220


Pro Asn Trp Ser Val Asn Val Lys Thr Ser Ala Asn Met Lys Ala Pro 
225                 230                 235                 240


Gln Ser Leu Ala Ser Ser Asn Ser Ala Gln Ala Arg Glu Asn Lys Asp 
                245                 250                 255


Phe Val Arg Pro Lys Leu Val Thr Ile Ile Arg Ser Gly Val Lys Pro 
            260                 265                 270


Arg Lys Ala Val Arg Val Leu Leu Asn Lys Lys Thr Ala His Ser Phe 
        275                 280                 285


Glu Gln Val Leu Thr Asp Ile Thr Glu Ala Ile Lys Leu Glu Thr Gly 
    290                 295                 300


Val Val Lys Lys Leu Tyr Thr Leu Asp Gly Lys Gln Val Thr Cys Leu 
305                 310                 315                 320


His Asp Phe Phe Gly Asp Asp Asp Val Phe Ile Ala Cys Gly Pro Glu 
                325                 330                 335


Lys Phe Arg Tyr Ala Gln Asp Asp Phe Ser Leu Asp Glu Asn Glu Cys 
            340                 345                 350


Arg Val Met Lys Gly Asn Pro Ser Ala Thr Ala Gly Pro Lys Ala Ser 
        355                 360                 365


Pro Thr Pro Gln Lys Thr Ser Ala Lys Ser Pro Gly Pro Met Arg Arg 
    370                 375                 380


Ser Lys Ser Pro Ala Asp Ser Ala Asn Gly Thr Ser Ser Ser Gln Leu 
385                 390                 395                 400


Ser Thr Pro Lys Ser Lys Gln Ser Pro Ile Ser Thr Pro Thr Ser Pro 
                405                 410                 415


Gly Ser Leu Arg Lys His Lys Asp Leu Tyr Leu Pro Leu Ser Leu Asp 
            420                 425                 430


Asp Ser Asp Ser Leu Gly Asp Ser Met 
        435                 440


<210>  1353
<211>  9122
<212>  DNA
<213>  Homo sapiens

<400>  1353
cacaaggcaa agcctgctct ctctgtctct ctgtctcctc ttctcctttt ttgccttatt     60

ctatccgatt ttttccctaa gcttctacct gggattttcc tttggaaaag tctctgaggt    120

tccaccaaaa tatggaactt gattttggac actttgacga aagagataag acatccagga    180

acatgcgagg ctcccggatg aatgggttgc ctagccccac tcacagcgcc cactgtagct    240

tctaccgaac cagaaccttg caggcactga gtaatgagaa gaaagccaag aaggtacgtt    300

tctaccgcaa tggggaccgc tacttcaagg ggattgtgta cgctgtgtcc tctgaccgtt    360

ttcgcagctt tgacgccttg ctggctgacc tgacgcgatc tctgtctgac aacatcaacc    420

tgcctcaggg agtgcgttac atttacacca ttgatggatc caggaagatc ggaagcatgg    480

atgaactgga ggaaggggaa agctatgtct gttcctcaga caacttcttt aaaaaggtgg    540

agtacaccaa gaatgtcaat cccaactggt ctgtcaacgt aaaaacatct gccaatatga    600

aagcccccca gtccttggct agcagcaaca gtgcacaggc cagggagaac aaggactttg    660

tgcgccccaa gctggttacc atcatccgca gtggggtgaa gcctcggaag gctgtgcgtg    720

tgcttctgaa caagaagaca gcccactctt ttgagcaagt cctcactgat atcacagaag    780

ccatcaaact ggagaccggg gttgtcaaaa aactctacac tctggatgga aaacaggtaa    840

cttgtctcca tgatttcttt ggtgatgatg atgtgtttat tgcctgtggt cctgaaaaat    900

ttcgctatgc tcaggatgat ttttctctgg atgaaaatga atgccgagtc atgaagggaa    960

acccatcagc cacagctggc ccaaaggcat ccccaacacc tcagaagact tcagccaaga   1020

gccctggtcc tatgcgccga agcaagtctc cagctgactc agcaaacgga acctccagca   1080

gccagctctc tacccccaag tctaagcagt ctcccatctc tacgcccacc agtcctggca   1140

gcctccggaa gcacaaggac ctgtacctgc ctctgtcctt ggatgactcg gactcgcttg   1200

gtgattccat gtaaaggagg ggagagtgct cagagtccag agtacaaatc caagcctatc   1260

attgtagtag ggtacttctg ctcaagtgtc caacagggct attggtgctt tcaagttttt   1320

attttgttgt tgttgttatt ttgaaaaaca cattgtaata tgttgggttt attttcctgt   1380

gatttctcct ctgggccact gatccacagt taccaattat gagagataga ttgataacca   1440

tcctttgggg cagcattcca gggatgcaaa atgtgctagt ccatgacctt tcaatggaaa   1500

gcttaggtgc ctgcgttata tttgccctgt ctaattttgc ccatacagtc ttccttctgt   1560

agagggctgt ttacatatac agcacttaaa atgtttgtgt gggaaaaaaa aaactcattg   1620

gcagatccaa gaatgacaaa cacaagtgcc ccttttctct ggatctcaag aatggtggag   1680

gaccctggaa ggacagcaag gcagctcccc agcctcactc ttcactcctg attgaggccc   1740

gggtttgttg tccagcacca attctggctg tcaatgggga gaaataaacc aacaacttat   1800

aattgtgaca ccagatgctt aggatcctgg tgctgggtta gctaagagaa tagacagaat   1860

tggaaaatac tgcagacatt tccgaagagt ttataaagca cagtgaattc ctggtcaatc   1920

tctccactga ggcaatttgg aatcaataag caattgataa tagtttggag taagggactt   1980

catatacctg attcctctag aaggctgtct aacataccac atgattacat gaactgtatg   2040

gtatccatct atctctgttc tattgaatgc cttgttaaca gccaacactg aaaacactgt   2100

gagaatttgt tttcaggtct gacacctttc agtctctttt tatagcaaga aatcaatatc   2160

ctttttataa aaattcatgt ctgtatttca ggagcaaact cttcaggctc cttttttata   2220

aactggtgat ttttcttttg tctaaaaaac acatgaagaa aatttaccaa aaaaaaaaaa   2280

aaaagcagaa gaataatgta gtttagaaat tatgctgtca ctgccaaaca gtaacctcca   2340

ggagaaaaca agatgaatag cagaggccaa ttcaatagaa tcagtttttt gatagctttt   2400

taacagttat gcttgcatta ataatttcaa tgtggaccag acattctaat tatattttaa   2460

atgaaatgtt acagcatatt ttaagcaact ctttttatct ataatcctaa tatttcatac   2520

tgaagacaca gaaatctttc acttgtcttt aacattagaa aggatttctc tttactaagg   2580

actgatcatt tgaaatagtt ttcagtcttt tgagatacag gtttataaca ctgctttttt   2640

ttttctgtaa tcatagccca taatggcaaa gacaactaaa tttaagtgaa ggtcatgcat   2700

gccaattctg tgtttgcttt tagcagatat gaagatttcc ttatttcttt gtaattgtgc   2760

agatattttg aaaggcacag cattcgaagc caagctgctg tttggctact gaatggcttg   2820

cagttgttcc tccactctaa atggaatgag cttgctgtgt gtgtgtgtgg tggtggtggg   2880

agggggtggt gcatgtgtgt gtgtgtgtgt gcatctgcag ctgcttcaaa attaggaaat   2940

actacaggac acccctgtaa tggattggtg gcaactgggt ggcactgctg atgtgcactg   3000

tgtagggggg aacccagtgg tggtggggta gctcagatgc ccctagacaa gcttcagatg   3060

tctgtagcta ccagaaacat tttcggttca ggaaaagtga gatgatggta gtactggttt   3120

ctggtgaaat tgaagaaccc caaatgatga ggatctcttt ttgccccctc tccttttttt   3180

gtagacccat tcaaaaccat taataagccc attttactaa gcccctattt ctttctagaa   3240

gctcagggtt ttcttagtgc ctcccagaac attttgtagt taattgggaa aaagtgatac   3300

ttggattagg gggtgtgggc ataaagaatg gtgggaggcc tgattttaaa cttcaggcca   3360

gaacccccaa tgactccacc catagtctca ctttaggtct catttagtcc atcaccttta   3420

ttttaagttg aggaagtgga ggctggtaaa gagcaggacc agaggaagaa tccagatttc   3480

cttatgcttg ggcctcacac tagctctctg agtatttcct tgattgcggt atatgtacta   3540

ctagaaaata ccaaatggat atattttctt taggataacc tttgaaccaa caatcttcaa   3600

taacaatagt acatcttcca tcttactttt aatcgagtat aaggaaatgt ttctttatgg   3660

ccattttgga gggagcaggg gatgaggctt ggcatagtcc aaaatttaag tctccaataa   3720

ttaattgcat tttaaattgg cccactttca aggcaatttt ttttgtgtgt ctgtaactga   3780

gctcctccac ccctgtcatt cacttccaat tttacccaat ccaattttag cactcaagtt   3840

ccattgtgtt aatttctgca cggtcaacaa acatcaagtc agcaagcatt tgccaccact   3900

ccctatactt ctccctcctt cttacacaca cacacacaca cacacacaca atccatctct   3960

tgcttgttcc tacctcctga tttttcttcc ctacagaaat agaaataggg acaaagaagg   4020

ggaaaatgta tatattgggg ctgggctgaa caactaactt cataagtagt attaactagg   4080

ggtaaattga gagaaaagct ccttttctct tcactgtttt ggaaaggata gccattagca   4140

tgactgcttt gtgtccttat ggactttagt attagcctag attgaattat agcgttttct   4200

agctggaagg aaccttaaga tcacatcatc tactcctcta ctccaaattt ctcattcttc   4260

aggccaggaa accgagacac agaggtaaag taatttcccc aaggtcacac agctggctgg   4320

ggcaggattg ggtttacaac ccacatctcc tggctcttat tccagggcct tttcccacta   4380

agtagtattg ccttccatta ggctcctgag agttatttct cagggtcatg ttgcatcttg   4440

gagccacatg ctgctgccct gatctcagtg ggaaatccac ccagcaacct aatacagccc   4500

cttttccctg cattcacctg gttcccatcc acatgggttg cagatgtcct tgaagagagt   4560

gaggcattga gggccaatag gagcaatggg gtccctggcc ttgtccatct gattcaggag   4620

atcactgctc catcgtgagg agccctctga atagcccccc actgaatgct tgccttgccc   4680

aaatggaatg gaggaagatt gattttctcc atcagttcac cttgtgtcat ctcataatgg   4740

ttggtctttc caggctgagg gaaatgtttc ttgtttccag agtagaaaaa gaaagagtgg   4800

aacaatagct ttgttcatcc taactttctg agatggcttt tcaacatttt aaaaaaacta   4860

gtgtggctac cattcactgg caatgatttc ttttagaata tgggagtaag atgagctaga   4920

gaaaataacc tggtctcact gtggttgccc tcatccacaa tgtccccaaa gccatcctgc   4980

tctgatgagg acaatttcca ggtataagca aggggctttg tgacaaaaat gtaccctggc   5040

tgatgttaaa cattggctcc tgtgtttgca ccaaaatagc aagctgtgtg ctctatacac   5100

tcttcccatc gtcttgtgta cactgctcct gtggccttcc acagcagaaa ccagggcaaa   5160

agggtccaaa cacatggttt tccttgctgc aaggctcttc ctgggaacta agggggtatt   5220

tattagttca gttctaagag acctccttct gggcttaccc cactcctcag gtacttctct   5280

ctccttcctc cttctcctcc acagtcacaa gtaaccaagg aacctgaaag tggatgtgta   5340

gctatttgaa gaaggcaagg aaccctgaga ttcttctttg aatcctctag tccaagtctt   5400

agaccagtga ttggtgctta ccttgaacaa aattttgtct gtgttcctaa tcccttcaat   5460

actctgggta caatgctccc aatcaccctg cacatttgat tctaaatggc ttttattttt   5520

taaaaatcca tatccctagg acaagagaac aggatgccta tatccccaaa atgagctcca   5580

ggacactgat gggaatgatc ccaaagatca ccccacctca gaaacgtctg tgccaagaga   5640

cttccccaga tagaaacact gggacagtgg tttgaacgac ttcttttatg gttgtccagt   5700

ttgctatgga aataaaaggc attgattttt taaaaagatg attggaacct gtctttggcc   5760

acatagggcc acttggatcc atttccaggc cttactcata tattgccttc actgaagggc   5820

tttggcttta agtcccagac tggtctccca agtgaaccat aagtgttttg gagctcatct   5880

ggggtgaggc atgagaatgt tgccccatct atcccttcag gaaaaggtgc cttccctccc   5940

tttctcctaa agcctggtcc ccagaaattg tttttgtctc caaaagtcta gtatggtctt   6000

tatacaccca gactcttagt gttgcgtcct gccttgtttc cttgttaagg atctatgcag   6060

acctcccgct ttggcttagc tagcgtgaca ttggctatca tttgacaaga ctaacttttt   6120

tttttttttt tttttgactg agtctccctc tgtcacctag gctggagtgc agtggcacaa   6180

tcttggctcg ctgcaacctt cacccttcac ctcccaggtc gaagcgattc tcctgcctca   6240

gtctcccgag tagctgggat tacaggcgtg cgccaccaaa tctggctatt tttttattat   6300

tattattttt agtagagatg gggtttcacc atgttggcca gactggtctt gaactcttgg   6360

cctcaaatta tctgcccacc tcggcctccc aaagtgctgg gattacaggc atgagccacc   6420

atgcccagct gacaagacta attttttatc ccttggttta ttggcttcaa catcttctgg   6480

aatcagaggt gattttttct taccttggat gcctgagact aggggagtat agaattccaa   6540

ttggtaatta aggcatcttt ctgctcctga tcagaagggc aggttagttg ggagaggtca   6600

gatggcacaa cagaagtcac cttgtaagta aggcaaagac ttgaaggcat tagcgtttct   6660

cattactagg tcaataacct gagggaatca atggcttttt gccgctctac ctcttgtgta   6720

tctctttgac ttttctttct ctgtctagtt tcctctgttc tcagtttata ttctatgtta   6780

tcagtctctc tttccacagt acaaacatcc atcctttctc ctgtgcaatt ctgtctctcc   6840

ctcttattat ctttatttgt actttttcct tcctccctgt ctaggcattg ggcatgtgcc   6900

tcttcttagc ctgtgatttt gccttgggac tgatgataaa ttatttccag attcaatcag   6960

ccctggtcct accccagtcc aatcagaagt atgttggtgg gaatcaacct gatcctggcc   7020

ctttcttctt ctccattttc attcgtaatc cccctcagca gatctttaca agcagtttcc   7080

ttatagctca tgtatcttta ggtctttgcc ttccaagcac tgtacagaat actttgtggt   7140

tcctttttag tctgacattt tgtggagcag tgaagcgtgc tcagagacat aatcagctga   7200

agagaaaaaa tccacccatg gatttatatc agctaaatac taataattga ttttgtttga   7260

tgtgcccata atttttaaag ctgcaatata atataatgag ggaccacagg taatttctcc   7320

tgtcatttgt tttggctgga tgggggtggg ggagtaattg cttaaagttt taccattaca   7380

cattaaactc tctataataa tcttgtttgg ggcttgctaa ctgttgagct gttttaacta   7440

aactggtagg caatcggagt tgatttaaat gaaaagataa tttaacaaat ctatactata   7500

aaaagagaca tttgcttaat tgacatgtat tttttccttc tgagtcacct aaacatttac   7560

tcttgacacc aactgttcat gatactgaat agacagtcca tataagagaa attagtggac   7620

ctaaagaagc cagattgtag gtgttaattt attaaacaga gtgcaaagcc cttggaaatg   7680

tcactgcttg gcaataccat atggaatgcc aaaatttaca atgacttttc tttataagtt   7740

atccaaaagg gatttgaaca agtaagaggt tatgccaaaa tgtctccaat gtatggtcct   7800

gtaatatatt gcagcttgaa gccaatgatc ccttatgact tgtatacaac taatgcatgt   7860

tttattgaat tttgcatttc ccacgtgtgg taagttcttt aaaatgtttt tgatcacctt   7920

tttgtgccat taaacttgta cagaaaatgt ttttatggcc attttcaaag ggagaaagtt   7980

taaaatggaa acagcccacc ctttctgccc tatagctgta gttagaattg agtacctgta   8040

gcaaaacagc tgtaattggt ggttgtagtg ttagaggtgt tagcttgcta gtgactagct   8100

ttggagagta aatgcatggt attgtacatc acatttctta actcgtttta acctctgaaa   8160

agaatatatt cttctttgta gtccttcttc ccaccccctt gccctctccc tctccctgct   8220

cccagttgtc ttacagttgt aaatatctga tttgaggccc aataactctt gccaagtaaa   8280

gtcagcaaac aacaaacaaa ccaaaatgtg gggaaaaggc atttctcaac catctctcag   8340

cagttattga tcatttctta aggaacagca ttgtgatcaa agactcaact ttacgtaaaa   8400

atcagtggta aattggggtt gtatttggcc atttgattac atttcaggat tgaatagttt   8460

tcagaatcac atgtaatcca aagacagtag gtagtgatgt cccttatccc tgcagctgtt   8520

ttaagataga gacctcagaa gactctgctt gaccgatgac caataattat ttgaaaaaaa   8580

aagaaaaaat gagagaaata aaacagatat ttaagaactt tagccaccta tttagaatag   8640

ttatagccag aaaaaaaaac aagggcatga gttcaaatgc attactatca gtgtcctagg   8700

caatacctaa cctactctga aattgtgatt caaaagcagt atttcaagag gcattctcct   8760

tttttggttt gctgacccca cttggactgg taggtttggt gaggccccca taaaccagct   8820

ggagcagacc cttttcatct cctgtgcctg taacacccct cttcccccac cccctccgca   8880

attcaatgag ggctttcttg ggtcagagga cttcaaggtt gtctagagaa gtttgccatg   8940

tgtgtaaggt gctgtgaact gtgagtgctg aagattcgca gcattcaata ccaggcagcc   9000

aaagagctgc tcttgcaatt attttggctc tcaagctctg ttcttcatcg cattctcatt   9060

tctgtgtaca tttgcaagat gtgtgtaatg tcattttcca aaaataaaat ttgatttcaa   9120

ta                                                                  9122


<210>  1354
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  1354

Met Glu Leu Asp Phe Gly His Phe Asp Glu Arg Asp Lys Thr Ser Arg 
1               5                   10                  15


Asn Met Arg Gly Ser Arg Met Asn Gly Leu Pro Ser Pro Thr His Ser 
            20                  25                  30


Ala His Cys Ser Phe Tyr Arg Thr Arg Thr Leu Gln Ala Leu Ser Asn 
        35                  40                  45


Glu Lys Lys Ala Lys Lys Val Arg Phe Tyr Arg Asn Gly Asp Arg Tyr 
    50                  55                  60


Phe Lys Gly Ile Val Tyr Ala Val Ser Ser Asp Arg Phe Arg Ser Phe 
65                  70                  75                  80


Asp Ala Leu Leu Ala Asp Leu Thr Arg Ser Leu Ser Asp Asn Ile Asn 
                85                  90                  95


Leu Pro Gln Gly Val Arg Tyr Ile Tyr Thr Ile Asp Gly Ser Arg Lys 
            100                 105                 110


Ile Gly Ser Met Asp Glu Leu Glu Glu Gly Glu Ser Tyr Val Cys Ser 
        115                 120                 125


Ser Asp Asn Phe Phe Lys Lys Val Glu Tyr Thr Lys Asn Val Asn Pro 
    130                 135                 140


Asn Trp Ser Val Asn Val Lys Thr Ser Ala Asn Met Lys Ala Pro Gln 
145                 150                 155                 160


Ser Leu Ala Ser Ser Asn Ser Ala Gln Ala Arg Glu Asn Lys Asp Phe 
                165                 170                 175


Val Arg Pro Lys Leu Val Thr Ile Ile Arg Ser Gly Val Lys Pro Arg 
            180                 185                 190


Lys Ala Val Arg Val Leu Leu Asn Lys Lys Thr Ala His Ser Phe Glu 
        195                 200                 205


Gln Val Leu Thr Asp Ile Thr Glu Ala Ile Lys Leu Glu Thr Gly Val 
    210                 215                 220


Val Lys Lys Leu Tyr Thr Leu Asp Gly Lys Gln Val Thr Cys Leu His 
225                 230                 235                 240


Asp Phe Phe Gly Asp Asp Asp Val Phe Ile Ala Cys Gly Pro Glu Lys 
                245                 250                 255


Phe Arg Tyr Ala Gln Asp Asp Phe Ser Leu Asp Glu Asn Glu Cys Arg 
            260                 265                 270


Val Met Lys Gly Asn Pro Ser Ala Thr Ala Gly Pro Lys Ala Ser Pro 
        275                 280                 285


Thr Pro Gln Lys Thr Ser Ala Lys Ser Pro Gly Pro Met Arg Arg Ser 
    290                 295                 300


Lys Ser Pro Ala Asp Ser Ala Asn Gly Thr Ser Ser Ser Gln Leu Ser 
305                 310                 315                 320


Thr Pro Lys Ser Lys Gln Ser Pro Ile Ser Thr Pro Thr Ser Pro Gly 
                325                 330                 335


Ser Leu Arg Lys His Lys Asp Leu Tyr Leu Pro Leu Ser Leu Asp Asp 
            340                 345                 350


Ser Asp Ser Leu Gly Asp Ser Met 
        355                 360


<210>  1355
<211>  9069
<212>  DNA
<213>  Homo sapiens

<400>  1355
tttctttctc tcagcatctc cacccaacca gcagaaaacc ggtctctgag gttccaccaa     60

aatatggaac ttgattttgg acactttgac gaaagagata agacatccag gaacatgcga    120

ggctcccgga tgaatgggtt gcctagcccc actcacagcg cccactgtag cttctaccga    180

accagaacct tgcaggcact gagtaatgag aagaaagcca agaaggtacg tttctaccgc    240

aatggggacc gctacttcaa ggggattgtg tacgctgtgt cctctgaccg ttttcgcagc    300

tttgacgcct tgctggctga cctgacgcga tctctgtctg acaacatcaa cctgcctcag    360

ggagtgcgtt acatttacac cattgatgga tccaggaaga tcggaagcat ggatgaactg    420

gaggaagggg aaagctatgt ctgttcctca gacaacttct ttaaaaaggt ggagtacacc    480

aagaatgtca atcccaactg gtctgtcaac gtaaaaacat ctgccaatat gaaagccccc    540

cagtccttgg ctagcagcaa cagtgcacag gccagggaga acaaggactt tgtgcgcccc    600

aagctggtta ccatcatccg cagtggggtg aagcctcgga aggctgtgcg tgtgcttctg    660

aacaagaaga cagcccactc ttttgagcaa gtcctcactg atatcacaga agccatcaaa    720

ctggagaccg gggttgtcaa aaaactctac actctggatg gaaaacaggt aacttgtctc    780

catgatttct ttggtgatga tgatgtgttt attgcctgtg gtcctgaaaa atttcgctat    840

gctcaggatg atttttctct ggatgaaaat gaatgccgag tcatgaaggg aaacccatca    900

gccacagctg gcccaaaggc atccccaaca cctcagaaga cttcagccaa gagccctggt    960

cctatgcgcc gaagcaagtc tccagctgac tcaggtaacg accaagacgc aaacggaacc   1020

tccagcagcc agctctctac ccccaagtct aagcagtctc ccatctctac gcccaccagt   1080

cctggcagcc tccggaagca caaggacctg tacctgcctc tgtccttgga tgactcggac   1140

tcgcttggtg attccatgta aaggagggga gagtgctcag agtccagagt acaaatccaa   1200

gcctatcatt gtagtagggt acttctgctc aagtgtccaa cagggctatt ggtgctttca   1260

agtttttatt ttgttgttgt tgttattttg aaaaacacat tgtaatatgt tgggtttatt   1320

ttcctgtgat ttctcctctg ggccactgat ccacagttac caattatgag agatagattg   1380

ataaccatcc tttggggcag cattccaggg atgcaaaatg tgctagtcca tgacctttca   1440

atggaaagct taggtgcctg cgttatattt gccctgtcta attttgccca tacagtcttc   1500

cttctgtaga gggctgttta catatacagc acttaaaatg tttgtgtggg aaaaaaaaaa   1560

ctcattggca gatccaagaa tgacaaacac aagtgcccct tttctctgga tctcaagaat   1620

ggtggaggac cctggaagga cagcaaggca gctccccagc ctcactcttc actcctgatt   1680

gaggcccggg tttgttgtcc agcaccaatt ctggctgtca atggggagaa ataaaccaac   1740

aacttataat tgtgacacca gatgcttagg atcctggtgc tgggttagct aagagaatag   1800

acagaattgg aaaatactgc agacatttcc gaagagttta taaagcacag tgaattcctg   1860

gtcaatctct ccactgaggc aatttggaat caataagcaa ttgataatag tttggagtaa   1920

gggacttcat atacctgatt cctctagaag gctgtctaac ataccacatg attacatgaa   1980

ctgtatggta tccatctatc tctgttctat tgaatgcctt gttaacagcc aacactgaaa   2040

acactgtgag aatttgtttt caggtctgac acctttcagt ctctttttat agcaagaaat   2100

caatatcctt tttataaaaa ttcatgtctg tatttcagga gcaaactctt caggctcctt   2160

ttttataaac tggtgatttt tcttttgtct aaaaaacaca tgaagaaaat ttaccaaaaa   2220

aaaaaaaaaa agcagaagaa taatgtagtt tagaaattat gctgtcactg ccaaacagta   2280

acctccagga gaaaacaaga tgaatagcag aggccaattc aatagaatca gttttttgat   2340

agctttttaa cagttatgct tgcattaata atttcaatgt ggaccagaca ttctaattat   2400

attttaaatg aaatgttaca gcatatttta agcaactctt tttatctata atcctaatat   2460

ttcatactga agacacagaa atctttcact tgtctttaac attagaaagg atttctcttt   2520

actaaggact gatcatttga aatagttttc agtcttttga gatacaggtt tataacactg   2580

cttttttttt tctgtaatca tagcccataa tggcaaagac aactaaattt aagtgaaggt   2640

catgcatgcc aattctgtgt ttgcttttag cagatatgaa gatttcctta tttctttgta   2700

attgtgcaga tattttgaaa ggcacagcat tcgaagccaa gctgctgttt ggctactgaa   2760

tggcttgcag ttgttcctcc actctaaatg gaatgagctt gctgtgtgtg tgtgtggtgg   2820

tggtgggagg gggtggtgca tgtgtgtgtg tgtgtgtgca tctgcagctg cttcaaaatt   2880

aggaaatact acaggacacc cctgtaatgg attggtggca actgggtggc actgctgatg   2940

tgcactgtgt aggggggaac ccagtggtgg tggggtagct cagatgcccc tagacaagct   3000

tcagatgtct gtagctacca gaaacatttt cggttcagga aaagtgagat gatggtagta   3060

ctggtttctg gtgaaattga agaaccccaa atgatgagga tctctttttg ccccctctcc   3120

tttttttgta gacccattca aaaccattaa taagcccatt ttactaagcc cctatttctt   3180

tctagaagct cagggttttc ttagtgcctc ccagaacatt ttgtagttaa ttgggaaaaa   3240

gtgatacttg gattaggggg tgtgggcata aagaatggtg ggaggcctga ttttaaactt   3300

caggccagaa cccccaatga ctccacccat agtctcactt taggtctcat ttagtccatc   3360

acctttattt taagttgagg aagtggaggc tggtaaagag caggaccaga ggaagaatcc   3420

agatttcctt atgcttgggc ctcacactag ctctctgagt atttccttga ttgcggtata   3480

tgtactacta gaaaatacca aatggatata ttttctttag gataaccttt gaaccaacaa   3540

tcttcaataa caatagtaca tcttccatct tacttttaat cgagtataag gaaatgtttc   3600

tttatggcca ttttggaggg agcaggggat gaggcttggc atagtccaaa atttaagtct   3660

ccaataatta attgcatttt aaattggccc actttcaagg caattttttt tgtgtgtctg   3720

taactgagct cctccacccc tgtcattcac ttccaatttt acccaatcca attttagcac   3780

tcaagttcca ttgtgttaat ttctgcacgg tcaacaaaca tcaagtcagc aagcatttgc   3840

caccactccc tatacttctc cctccttctt acacacacac acacacacac acacacaatc   3900

catctcttgc ttgttcctac ctcctgattt ttcttcccta cagaaataga aatagggaca   3960

aagaagggga aaatgtatat attggggctg ggctgaacaa ctaacttcat aagtagtatt   4020

aactaggggt aaattgagag aaaagctcct tttctcttca ctgttttgga aaggatagcc   4080

attagcatga ctgctttgtg tccttatgga ctttagtatt agcctagatt gaattatagc   4140

gttttctagc tggaaggaac cttaagatca catcatctac tcctctactc caaatttctc   4200

attcttcagg ccaggaaacc gagacacaga ggtaaagtaa tttccccaag gtcacacagc   4260

tggctggggc aggattgggt ttacaaccca catctcctgg ctcttattcc agggcctttt   4320

cccactaagt agtattgcct tccattaggc tcctgagagt tatttctcag ggtcatgttg   4380

catcttggag ccacatgctg ctgccctgat ctcagtggga aatccaccca gcaacctaat   4440

acagcccctt ttccctgcat tcacctggtt cccatccaca tgggttgcag atgtccttga   4500

agagagtgag gcattgaggg ccaataggag caatggggtc cctggccttg tccatctgat   4560

tcaggagatc actgctccat cgtgaggagc cctctgaata gccccccact gaatgcttgc   4620

cttgcccaaa tggaatggag gaagattgat tttctccatc agttcacctt gtgtcatctc   4680

ataatggttg gtctttccag gctgagggaa atgtttcttg tttccagagt agaaaaagaa   4740

agagtggaac aatagctttg ttcatcctaa ctttctgaga tggcttttca acattttaaa   4800

aaaactagtg tggctaccat tcactggcaa tgatttcttt tagaatatgg gagtaagatg   4860

agctagagaa aataacctgg tctcactgtg gttgccctca tccacaatgt ccccaaagcc   4920

atcctgctct gatgaggaca atttccaggt ataagcaagg ggctttgtga caaaaatgta   4980

ccctggctga tgttaaacat tggctcctgt gtttgcacca aaatagcaag ctgtgtgctc   5040

tatacactct tcccatcgtc ttgtgtacac tgctcctgtg gccttccaca gcagaaacca   5100

gggcaaaagg gtccaaacac atggttttcc ttgctgcaag gctcttcctg ggaactaagg   5160

gggtatttat tagttcagtt ctaagagacc tccttctggg cttaccccac tcctcaggta   5220

cttctctctc cttcctcctt ctcctccaca gtcacaagta accaaggaac ctgaaagtgg   5280

atgtgtagct atttgaagaa ggcaaggaac cctgagattc ttctttgaat cctctagtcc   5340

aagtcttaga ccagtgattg gtgcttacct tgaacaaaat tttgtctgtg ttcctaatcc   5400

cttcaatact ctgggtacaa tgctcccaat caccctgcac atttgattct aaatggcttt   5460

tattttttaa aaatccatat ccctaggaca agagaacagg atgcctatat ccccaaaatg   5520

agctccagga cactgatggg aatgatccca aagatcaccc cacctcagaa acgtctgtgc   5580

caagagactt ccccagatag aaacactggg acagtggttt gaacgacttc ttttatggtt   5640

gtccagtttg ctatggaaat aaaaggcatt gattttttaa aaagatgatt ggaacctgtc   5700

tttggccaca tagggccact tggatccatt tccaggcctt actcatatat tgccttcact   5760

gaagggcttt ggctttaagt cccagactgg tctcccaagt gaaccataag tgttttggag   5820

ctcatctggg gtgaggcatg agaatgttgc cccatctatc ccttcaggaa aaggtgcctt   5880

ccctcccttt ctcctaaagc ctggtcccca gaaattgttt ttgtctccaa aagtctagta   5940

tggtctttat acacccagac tcttagtgtt gcgtcctgcc ttgtttcctt gttaaggatc   6000

tatgcagacc tcccgctttg gcttagctag cgtgacattg gctatcattt gacaagacta   6060

actttttttt tttttttttt ttgactgagt ctccctctgt cacctaggct ggagtgcagt   6120

ggcacaatct tggctcgctg caaccttcac ccttcacctc ccaggtcgaa gcgattctcc   6180

tgcctcagtc tcccgagtag ctgggattac aggcgtgcgc caccaaatct ggctattttt   6240

ttattattat tatttttagt agagatgggg tttcaccatg ttggccagac tggtcttgaa   6300

ctcttggcct caaattatct gcccacctcg gcctcccaaa gtgctgggat tacaggcatg   6360

agccaccatg cccagctgac aagactaatt ttttatccct tggtttattg gcttcaacat   6420

cttctggaat cagaggtgat tttttcttac cttggatgcc tgagactagg ggagtataga   6480

attccaattg gtaattaagg catctttctg ctcctgatca gaagggcagg ttagttggga   6540

gaggtcagat ggcacaacag aagtcacctt gtaagtaagg caaagacttg aaggcattag   6600

cgtttctcat tactaggtca ataacctgag ggaatcaatg gctttttgcc gctctacctc   6660

ttgtgtatct ctttgacttt tctttctctg tctagtttcc tctgttctca gtttatattc   6720

tatgttatca gtctctcttt ccacagtaca aacatccatc ctttctcctg tgcaattctg   6780

tctctccctc ttattatctt tatttgtact ttttccttcc tccctgtcta ggcattgggc   6840

atgtgcctct tcttagcctg tgattttgcc ttgggactga tgataaatta tttccagatt   6900

caatcagccc tggtcctacc ccagtccaat cagaagtatg ttggtgggaa tcaacctgat   6960

cctggccctt tcttcttctc cattttcatt cgtaatcccc ctcagcagat ctttacaagc   7020

agtttcctta tagctcatgt atctttaggt ctttgccttc caagcactgt acagaatact   7080

ttgtggttcc tttttagtct gacattttgt ggagcagtga agcgtgctca gagacataat   7140

cagctgaaga gaaaaaatcc acccatggat ttatatcagc taaatactaa taattgattt   7200

tgtttgatgt gcccataatt tttaaagctg caatataata taatgaggga ccacaggtaa   7260

tttctcctgt catttgtttt ggctggatgg gggtggggga gtaattgctt aaagttttac   7320

cattacacat taaactctct ataataatct tgtttggggc ttgctaactg ttgagctgtt   7380

ttaactaaac tggtaggcaa tcggagttga tttaaatgaa aagataattt aacaaatcta   7440

tactataaaa agagacattt gcttaattga catgtatttt ttccttctga gtcacctaaa   7500

catttactct tgacaccaac tgttcatgat actgaataga cagtccatat aagagaaatt   7560

agtggaccta aagaagccag attgtaggtg ttaatttatt aaacagagtg caaagccctt   7620

ggaaatgtca ctgcttggca ataccatatg gaatgccaaa atttacaatg acttttcttt   7680

ataagttatc caaaagggat ttgaacaagt aagaggttat gccaaaatgt ctccaatgta   7740

tggtcctgta atatattgca gcttgaagcc aatgatccct tatgacttgt atacaactaa   7800

tgcatgtttt attgaatttt gcatttccca cgtgtggtaa gttctttaaa atgtttttga   7860

tcaccttttt gtgccattaa acttgtacag aaaatgtttt tatggccatt ttcaaaggga   7920

gaaagtttaa aatggaaaca gcccaccctt tctgccctat agctgtagtt agaattgagt   7980

acctgtagca aaacagctgt aattggtggt tgtagtgtta gaggtgttag cttgctagtg   8040

actagctttg gagagtaaat gcatggtatt gtacatcaca tttcttaact cgttttaacc   8100

tctgaaaaga atatattctt ctttgtagtc cttcttccca cccccttgcc ctctccctct   8160

ccctgctccc agttgtctta cagttgtaaa tatctgattt gaggcccaat aactcttgcc   8220

aagtaaagtc agcaaacaac aaacaaacca aaatgtgggg aaaaggcatt tctcaaccat   8280

ctctcagcag ttattgatca tttcttaagg aacagcattg tgatcaaaga ctcaacttta   8340

cgtaaaaatc agtggtaaat tggggttgta tttggccatt tgattacatt tcaggattga   8400

atagttttca gaatcacatg taatccaaag acagtaggta gtgatgtccc ttatccctgc   8460

agctgtttta agatagagac ctcagaagac tctgcttgac cgatgaccaa taattatttg   8520

aaaaaaaaag aaaaaatgag agaaataaaa cagatattta agaactttag ccacctattt   8580

agaatagtta tagccagaaa aaaaaacaag ggcatgagtt caaatgcatt actatcagtg   8640

tcctaggcaa tacctaacct actctgaaat tgtgattcaa aagcagtatt tcaagaggca   8700

ttctcctttt ttggtttgct gaccccactt ggactggtag gtttggtgag gcccccataa   8760

accagctgga gcagaccctt ttcatctcct gtgcctgtaa cacccctctt cccccacccc   8820

ctccgcaatt caatgagggc tttcttgggt cagaggactt caaggttgtc tagagaagtt   8880

tgccatgtgt gtaaggtgct gtgaactgtg agtgctgaag attcgcagca ttcaatacca   8940

ggcagccaaa gagctgctct tgcaattatt ttggctctca agctctgttc ttcatcgcat   9000

tctcatttct gtgtacattt gcaagatgtg tgtaatgtca ttttccaaaa ataaaatttg   9060

atttcaata                                                           9069


<210>  1356
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  1356

Met Glu Leu Asp Phe Gly His Phe Asp Glu Arg Asp Lys Thr Ser Arg 
1               5                   10                  15


Asn Met Arg Gly Ser Arg Met Asn Gly Leu Pro Ser Pro Thr His Ser 
            20                  25                  30


Ala His Cys Ser Phe Tyr Arg Thr Arg Thr Leu Gln Ala Leu Ser Asn 
        35                  40                  45


Glu Lys Lys Ala Lys Lys Val Arg Phe Tyr Arg Asn Gly Asp Arg Tyr 
    50                  55                  60


Phe Lys Gly Ile Val Tyr Ala Val Ser Ser Asp Arg Phe Arg Ser Phe 
65                  70                  75                  80


Asp Ala Leu Leu Ala Asp Leu Thr Arg Ser Leu Ser Asp Asn Ile Asn 
                85                  90                  95


Leu Pro Gln Gly Val Arg Tyr Ile Tyr Thr Ile Asp Gly Ser Arg Lys 
            100                 105                 110


Ile Gly Ser Met Asp Glu Leu Glu Glu Gly Glu Ser Tyr Val Cys Ser 
        115                 120                 125


Ser Asp Asn Phe Phe Lys Lys Val Glu Tyr Thr Lys Asn Val Asn Pro 
    130                 135                 140


Asn Trp Ser Val Asn Val Lys Thr Ser Ala Asn Met Lys Ala Pro Gln 
145                 150                 155                 160


Ser Leu Ala Ser Ser Asn Ser Ala Gln Ala Arg Glu Asn Lys Asp Phe 
                165                 170                 175


Val Arg Pro Lys Leu Val Thr Ile Ile Arg Ser Gly Val Lys Pro Arg 
            180                 185                 190


Lys Ala Val Arg Val Leu Leu Asn Lys Lys Thr Ala His Ser Phe Glu 
        195                 200                 205


Gln Val Leu Thr Asp Ile Thr Glu Ala Ile Lys Leu Glu Thr Gly Val 
    210                 215                 220


Val Lys Lys Leu Tyr Thr Leu Asp Gly Lys Gln Val Thr Cys Leu His 
225                 230                 235                 240


Asp Phe Phe Gly Asp Asp Asp Val Phe Ile Ala Cys Gly Pro Glu Lys 
                245                 250                 255


Phe Arg Tyr Ala Gln Asp Asp Phe Ser Leu Asp Glu Asn Glu Cys Arg 
            260                 265                 270


Val Met Lys Gly Asn Pro Ser Ala Thr Ala Gly Pro Lys Ala Ser Pro 
        275                 280                 285


Thr Pro Gln Lys Thr Ser Ala Lys Ser Pro Gly Pro Met Arg Arg Ser 
    290                 295                 300


Lys Ser Pro Ala Asp Ser Gly Asn Asp Gln Asp Ala Asn Gly Thr Ser 
305                 310                 315                 320


Ser Ser Gln Leu Ser Thr Pro Lys Ser Lys Gln Ser Pro Ile Ser Thr 
                325                 330                 335


Pro Thr Ser Pro Gly Ser Leu Arg Lys His Lys Asp Leu Tyr Leu Pro 
            340                 345                 350


Leu Ser Leu Asp Asp Ser Asp Ser Leu Gly Asp Ser Met 
        355                 360                 365


<210>  1357
<211>  9054
<212>  DNA
<213>  Homo sapiens

<400>  1357
tttctttctc tcagcatctc cacccaacca gcagaaaacc ggtctctgag gttccaccaa     60

aatatggaac ttgattttgg acactttgac gaaagagata agacatccag gaacatgcga    120

ggctcccgga tgaatgggtt gcctagcccc actcacagcg cccactgtag cttctaccga    180

accagaacct tgcaggcact gagtaatgag aagaaagcca agaaggtacg tttctaccgc    240

aatggggacc gctacttcaa ggggattgtg tacgctgtgt cctctgaccg ttttcgcagc    300

tttgacgcct tgctggctga cctgacgcga tctctgtctg acaacatcaa cctgcctcag    360

ggagtgcgtt acatttacac cattgatgga tccaggaaga tcggaagcat ggatgaactg    420

gaggaagggg aaagctatgt ctgttcctca gacaacttct ttaaaaaggt ggagtacacc    480

aagaatgtca atcccaactg gtctgtcaac gtaaaaacat ctgccaatat gaaagccccc    540

cagtccttgg ctagcagcaa cagtgcacag gccagggaga acaaggactt tgtgcgcccc    600

aagctggtta ccatcatccg cagtggggtg aagcctcgga aggctgtgcg tgtgcttctg    660

aacaagaaga cagcccactc ttttgagcaa gtcctcactg atatcacaga agccatcaaa    720

ctggagaccg gggttgtcaa aaaactctac actctggatg gaaaacaggt aacttgtctc    780

catgatttct ttggtgatga tgatgtgttt attgcctgtg gtcctgaaaa atttcgctat    840

gctcaggatg atttttctct ggatgaaaat gaatgccgag tcatgaaggg aaacccatca    900

gccacagctg gcccaaaggc atccccaaca cctcagaaga cttcagccaa gagccctggt    960

cctatgcgcc gaagcaagtc tccagctgac tcagcaaacg gaacctccag cagccagctc   1020

tctaccccca agtctaagca gtctcccatc tctacgccca ccagtcctgg cagcctccgg   1080

aagcacaagg acctgtacct gcctctgtcc ttggatgact cggactcgct tggtgattcc   1140

atgtaaagga ggggagagtg ctcagagtcc agagtacaaa tccaagccta tcattgtagt   1200

agggtacttc tgctcaagtg tccaacaggg ctattggtgc tttcaagttt ttattttgtt   1260

gttgttgtta ttttgaaaaa cacattgtaa tatgttgggt ttattttcct gtgatttctc   1320

ctctgggcca ctgatccaca gttaccaatt atgagagata gattgataac catcctttgg   1380

ggcagcattc cagggatgca aaatgtgcta gtccatgacc tttcaatgga aagcttaggt   1440

gcctgcgtta tatttgccct gtctaatttt gcccatacag tcttccttct gtagagggct   1500

gtttacatat acagcactta aaatgtttgt gtgggaaaaa aaaaactcat tggcagatcc   1560

aagaatgaca aacacaagtg ccccttttct ctggatctca agaatggtgg aggaccctgg   1620

aaggacagca aggcagctcc ccagcctcac tcttcactcc tgattgaggc ccgggtttgt   1680

tgtccagcac caattctggc tgtcaatggg gagaaataaa ccaacaactt ataattgtga   1740

caccagatgc ttaggatcct ggtgctgggt tagctaagag aatagacaga attggaaaat   1800

actgcagaca tttccgaaga gtttataaag cacagtgaat tcctggtcaa tctctccact   1860

gaggcaattt ggaatcaata agcaattgat aatagtttgg agtaagggac ttcatatacc   1920

tgattcctct agaaggctgt ctaacatacc acatgattac atgaactgta tggtatccat   1980

ctatctctgt tctattgaat gccttgttaa cagccaacac tgaaaacact gtgagaattt   2040

gttttcaggt ctgacacctt tcagtctctt tttatagcaa gaaatcaata tcctttttat   2100

aaaaattcat gtctgtattt caggagcaaa ctcttcaggc tcctttttta taaactggtg   2160

atttttcttt tgtctaaaaa acacatgaag aaaatttacc aaaaaaaaaa aaaaaagcag   2220

aagaataatg tagtttagaa attatgctgt cactgccaaa cagtaacctc caggagaaaa   2280

caagatgaat agcagaggcc aattcaatag aatcagtttt ttgatagctt tttaacagtt   2340

atgcttgcat taataatttc aatgtggacc agacattcta attatatttt aaatgaaatg   2400

ttacagcata ttttaagcaa ctctttttat ctataatcct aatatttcat actgaagaca   2460

cagaaatctt tcacttgtct ttaacattag aaaggatttc tctttactaa ggactgatca   2520

tttgaaatag ttttcagtct tttgagatac aggtttataa cactgctttt ttttttctgt   2580

aatcatagcc cataatggca aagacaacta aatttaagtg aaggtcatgc atgccaattc   2640

tgtgtttgct tttagcagat atgaagattt ccttatttct ttgtaattgt gcagatattt   2700

tgaaaggcac agcattcgaa gccaagctgc tgtttggcta ctgaatggct tgcagttgtt   2760

cctccactct aaatggaatg agcttgctgt gtgtgtgtgt ggtggtggtg ggagggggtg   2820

gtgcatgtgt gtgtgtgtgt gtgcatctgc agctgcttca aaattaggaa atactacagg   2880

acacccctgt aatggattgg tggcaactgg gtggcactgc tgatgtgcac tgtgtagggg   2940

ggaacccagt ggtggtgggg tagctcagat gcccctagac aagcttcaga tgtctgtagc   3000

taccagaaac attttcggtt caggaaaagt gagatgatgg tagtactggt ttctggtgaa   3060

attgaagaac cccaaatgat gaggatctct ttttgccccc tctccttttt ttgtagaccc   3120

attcaaaacc attaataagc ccattttact aagcccctat ttctttctag aagctcaggg   3180

ttttcttagt gcctcccaga acattttgta gttaattggg aaaaagtgat acttggatta   3240

gggggtgtgg gcataaagaa tggtgggagg cctgatttta aacttcaggc cagaaccccc   3300

aatgactcca cccatagtct cactttaggt ctcatttagt ccatcacctt tattttaagt   3360

tgaggaagtg gaggctggta aagagcagga ccagaggaag aatccagatt tccttatgct   3420

tgggcctcac actagctctc tgagtatttc cttgattgcg gtatatgtac tactagaaaa   3480

taccaaatgg atatattttc tttaggataa cctttgaacc aacaatcttc aataacaata   3540

gtacatcttc catcttactt ttaatcgagt ataaggaaat gtttctttat ggccattttg   3600

gagggagcag gggatgaggc ttggcatagt ccaaaattta agtctccaat aattaattgc   3660

attttaaatt ggcccacttt caaggcaatt ttttttgtgt gtctgtaact gagctcctcc   3720

acccctgtca ttcacttcca attttaccca atccaatttt agcactcaag ttccattgtg   3780

ttaatttctg cacggtcaac aaacatcaag tcagcaagca tttgccacca ctccctatac   3840

ttctccctcc ttcttacaca cacacacaca cacacacaca caatccatct cttgcttgtt   3900

cctacctcct gatttttctt ccctacagaa atagaaatag ggacaaagaa ggggaaaatg   3960

tatatattgg ggctgggctg aacaactaac ttcataagta gtattaacta ggggtaaatt   4020

gagagaaaag ctccttttct cttcactgtt ttggaaagga tagccattag catgactgct   4080

ttgtgtcctt atggacttta gtattagcct agattgaatt atagcgtttt ctagctggaa   4140

ggaaccttaa gatcacatca tctactcctc tactccaaat ttctcattct tcaggccagg   4200

aaaccgagac acagaggtaa agtaatttcc ccaaggtcac acagctggct ggggcaggat   4260

tgggtttaca acccacatct cctggctctt attccagggc cttttcccac taagtagtat   4320

tgccttccat taggctcctg agagttattt ctcagggtca tgttgcatct tggagccaca   4380

tgctgctgcc ctgatctcag tgggaaatcc acccagcaac ctaatacagc cccttttccc   4440

tgcattcacc tggttcccat ccacatgggt tgcagatgtc cttgaagaga gtgaggcatt   4500

gagggccaat aggagcaatg gggtccctgg ccttgtccat ctgattcagg agatcactgc   4560

tccatcgtga ggagccctct gaatagcccc ccactgaatg cttgccttgc ccaaatggaa   4620

tggaggaaga ttgattttct ccatcagttc accttgtgtc atctcataat ggttggtctt   4680

tccaggctga gggaaatgtt tcttgtttcc agagtagaaa aagaaagagt ggaacaatag   4740

ctttgttcat cctaactttc tgagatggct tttcaacatt ttaaaaaaac tagtgtggct   4800

accattcact ggcaatgatt tcttttagaa tatgggagta agatgagcta gagaaaataa   4860

cctggtctca ctgtggttgc cctcatccac aatgtcccca aagccatcct gctctgatga   4920

ggacaatttc caggtataag caaggggctt tgtgacaaaa atgtaccctg gctgatgtta   4980

aacattggct cctgtgtttg caccaaaata gcaagctgtg tgctctatac actcttccca   5040

tcgtcttgtg tacactgctc ctgtggcctt ccacagcaga aaccagggca aaagggtcca   5100

aacacatggt tttccttgct gcaaggctct tcctgggaac taagggggta tttattagtt   5160

cagttctaag agacctcctt ctgggcttac cccactcctc aggtacttct ctctccttcc   5220

tccttctcct ccacagtcac aagtaaccaa ggaacctgaa agtggatgtg tagctatttg   5280

aagaaggcaa ggaaccctga gattcttctt tgaatcctct agtccaagtc ttagaccagt   5340

gattggtgct taccttgaac aaaattttgt ctgtgttcct aatcccttca atactctggg   5400

tacaatgctc ccaatcaccc tgcacatttg attctaaatg gcttttattt tttaaaaatc   5460

catatcccta ggacaagaga acaggatgcc tatatcccca aaatgagctc caggacactg   5520

atgggaatga tcccaaagat caccccacct cagaaacgtc tgtgccaaga gacttcccca   5580

gatagaaaca ctgggacagt ggtttgaacg acttctttta tggttgtcca gtttgctatg   5640

gaaataaaag gcattgattt tttaaaaaga tgattggaac ctgtctttgg ccacataggg   5700

ccacttggat ccatttccag gccttactca tatattgcct tcactgaagg gctttggctt   5760

taagtcccag actggtctcc caagtgaacc ataagtgttt tggagctcat ctggggtgag   5820

gcatgagaat gttgccccat ctatcccttc aggaaaaggt gccttccctc cctttctcct   5880

aaagcctggt ccccagaaat tgtttttgtc tccaaaagtc tagtatggtc tttatacacc   5940

cagactctta gtgttgcgtc ctgccttgtt tccttgttaa ggatctatgc agacctcccg   6000

ctttggctta gctagcgtga cattggctat catttgacaa gactaacttt tttttttttt   6060

tttttttgac tgagtctccc tctgtcacct aggctggagt gcagtggcac aatcttggct   6120

cgctgcaacc ttcacccttc acctcccagg tcgaagcgat tctcctgcct cagtctcccg   6180

agtagctggg attacaggcg tgcgccacca aatctggcta tttttttatt attattattt   6240

ttagtagaga tggggtttca ccatgttggc cagactggtc ttgaactctt ggcctcaaat   6300

tatctgccca cctcggcctc ccaaagtgct gggattacag gcatgagcca ccatgcccag   6360

ctgacaagac taatttttta tcccttggtt tattggcttc aacatcttct ggaatcagag   6420

gtgatttttt cttaccttgg atgcctgaga ctaggggagt atagaattcc aattggtaat   6480

taaggcatct ttctgctcct gatcagaagg gcaggttagt tgggagaggt cagatggcac   6540

aacagaagtc accttgtaag taaggcaaag acttgaaggc attagcgttt ctcattacta   6600

ggtcaataac ctgagggaat caatggcttt ttgccgctct acctcttgtg tatctctttg   6660

acttttcttt ctctgtctag tttcctctgt tctcagttta tattctatgt tatcagtctc   6720

tctttccaca gtacaaacat ccatcctttc tcctgtgcaa ttctgtctct ccctcttatt   6780

atctttattt gtactttttc cttcctccct gtctaggcat tgggcatgtg cctcttctta   6840

gcctgtgatt ttgccttggg actgatgata aattatttcc agattcaatc agccctggtc   6900

ctaccccagt ccaatcagaa gtatgttggt gggaatcaac ctgatcctgg ccctttcttc   6960

ttctccattt tcattcgtaa tccccctcag cagatcttta caagcagttt ccttatagct   7020

catgtatctt taggtctttg ccttccaagc actgtacaga atactttgtg gttccttttt   7080

agtctgacat tttgtggagc agtgaagcgt gctcagagac ataatcagct gaagagaaaa   7140

aatccaccca tggatttata tcagctaaat actaataatt gattttgttt gatgtgccca   7200

taatttttaa agctgcaata taatataatg agggaccaca ggtaatttct cctgtcattt   7260

gttttggctg gatgggggtg ggggagtaat tgcttaaagt tttaccatta cacattaaac   7320

tctctataat aatcttgttt ggggcttgct aactgttgag ctgttttaac taaactggta   7380

ggcaatcgga gttgatttaa atgaaaagat aatttaacaa atctatacta taaaaagaga   7440

catttgctta attgacatgt attttttcct tctgagtcac ctaaacattt actcttgaca   7500

ccaactgttc atgatactga atagacagtc catataagag aaattagtgg acctaaagaa   7560

gccagattgt aggtgttaat ttattaaaca gagtgcaaag cccttggaaa tgtcactgct   7620

tggcaatacc atatggaatg ccaaaattta caatgacttt tctttataag ttatccaaaa   7680

gggatttgaa caagtaagag gttatgccaa aatgtctcca atgtatggtc ctgtaatata   7740

ttgcagcttg aagccaatga tcccttatga cttgtataca actaatgcat gttttattga   7800

attttgcatt tcccacgtgt ggtaagttct ttaaaatgtt tttgatcacc tttttgtgcc   7860

attaaacttg tacagaaaat gtttttatgg ccattttcaa agggagaaag tttaaaatgg   7920

aaacagccca ccctttctgc cctatagctg tagttagaat tgagtacctg tagcaaaaca   7980

gctgtaattg gtggttgtag tgttagaggt gttagcttgc tagtgactag ctttggagag   8040

taaatgcatg gtattgtaca tcacatttct taactcgttt taacctctga aaagaatata   8100

ttcttctttg tagtccttct tcccaccccc ttgccctctc cctctccctg ctcccagttg   8160

tcttacagtt gtaaatatct gatttgaggc ccaataactc ttgccaagta aagtcagcaa   8220

acaacaaaca aaccaaaatg tggggaaaag gcatttctca accatctctc agcagttatt   8280

gatcatttct taaggaacag cattgtgatc aaagactcaa ctttacgtaa aaatcagtgg   8340

taaattgggg ttgtatttgg ccatttgatt acatttcagg attgaatagt tttcagaatc   8400

acatgtaatc caaagacagt aggtagtgat gtcccttatc cctgcagctg ttttaagata   8460

gagacctcag aagactctgc ttgaccgatg accaataatt atttgaaaaa aaaagaaaaa   8520

atgagagaaa taaaacagat atttaagaac tttagccacc tatttagaat agttatagcc   8580

agaaaaaaaa acaagggcat gagttcaaat gcattactat cagtgtccta ggcaatacct   8640

aacctactct gaaattgtga ttcaaaagca gtatttcaag aggcattctc cttttttggt   8700

ttgctgaccc cacttggact ggtaggtttg gtgaggcccc cataaaccag ctggagcaga   8760

cccttttcat ctcctgtgcc tgtaacaccc ctcttccccc accccctccg caattcaatg   8820

agggctttct tgggtcagag gacttcaagg ttgtctagag aagtttgcca tgtgtgtaag   8880

gtgctgtgaa ctgtgagtgc tgaagattcg cagcattcaa taccaggcag ccaaagagct   8940

gctcttgcaa ttattttggc tctcaagctc tgttcttcat cgcattctca tttctgtgta   9000

catttgcaag atgtgtgtaa tgtcattttc caaaaataaa atttgatttc aata         9054


<210>  1358
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  1358

Met Glu Leu Asp Phe Gly His Phe Asp Glu Arg Asp Lys Thr Ser Arg 
1               5                   10                  15


Asn Met Arg Gly Ser Arg Met Asn Gly Leu Pro Ser Pro Thr His Ser 
            20                  25                  30


Ala His Cys Ser Phe Tyr Arg Thr Arg Thr Leu Gln Ala Leu Ser Asn 
        35                  40                  45


Glu Lys Lys Ala Lys Lys Val Arg Phe Tyr Arg Asn Gly Asp Arg Tyr 
    50                  55                  60


Phe Lys Gly Ile Val Tyr Ala Val Ser Ser Asp Arg Phe Arg Ser Phe 
65                  70                  75                  80


Asp Ala Leu Leu Ala Asp Leu Thr Arg Ser Leu Ser Asp Asn Ile Asn 
                85                  90                  95


Leu Pro Gln Gly Val Arg Tyr Ile Tyr Thr Ile Asp Gly Ser Arg Lys 
            100                 105                 110


Ile Gly Ser Met Asp Glu Leu Glu Glu Gly Glu Ser Tyr Val Cys Ser 
        115                 120                 125


Ser Asp Asn Phe Phe Lys Lys Val Glu Tyr Thr Lys Asn Val Asn Pro 
    130                 135                 140


Asn Trp Ser Val Asn Val Lys Thr Ser Ala Asn Met Lys Ala Pro Gln 
145                 150                 155                 160


Ser Leu Ala Ser Ser Asn Ser Ala Gln Ala Arg Glu Asn Lys Asp Phe 
                165                 170                 175


Val Arg Pro Lys Leu Val Thr Ile Ile Arg Ser Gly Val Lys Pro Arg 
            180                 185                 190


Lys Ala Val Arg Val Leu Leu Asn Lys Lys Thr Ala His Ser Phe Glu 
        195                 200                 205


Gln Val Leu Thr Asp Ile Thr Glu Ala Ile Lys Leu Glu Thr Gly Val 
    210                 215                 220


Val Lys Lys Leu Tyr Thr Leu Asp Gly Lys Gln Val Thr Cys Leu His 
225                 230                 235                 240


Asp Phe Phe Gly Asp Asp Asp Val Phe Ile Ala Cys Gly Pro Glu Lys 
                245                 250                 255


Phe Arg Tyr Ala Gln Asp Asp Phe Ser Leu Asp Glu Asn Glu Cys Arg 
            260                 265                 270


Val Met Lys Gly Asn Pro Ser Ala Thr Ala Gly Pro Lys Ala Ser Pro 
        275                 280                 285


Thr Pro Gln Lys Thr Ser Ala Lys Ser Pro Gly Pro Met Arg Arg Ser 
    290                 295                 300


Lys Ser Pro Ala Asp Ser Ala Asn Gly Thr Ser Ser Ser Gln Leu Ser 
305                 310                 315                 320


Thr Pro Lys Ser Lys Gln Ser Pro Ile Ser Thr Pro Thr Ser Pro Gly 
                325                 330                 335


Ser Leu Arg Lys His Lys Asp Leu Tyr Leu Pro Leu Ser Leu Asp Asp 
            340                 345                 350


Ser Asp Ser Leu Gly Asp Ser Met 
        355                 360


<210>  1359
<211>  1451
<212>  DNA
<213>  Homo sapiens

<400>  1359
ggagataaga ttcagaggtt gaggatgggg tgtcctggtg gactgaaggt agcctactag     60

ctgtacatgg gtgacaactt gaaacttcag aaccctgaag tttaaaaaat tctaaaggtg    120

cctgtcatct cagagagtga cgtaagtgtt ctttctttat ttgggggaag tccaggagaa    180

catattacag acatgtttaa tccacatgca ttagatgttc ctgctgtaat ttttgacaat    240

ggttcaggac tctgcaaagc aggcctgtct ggagagattg gaccccgcca tgtcatcagc    300

tccgtcttgg gacattgtaa attcaatgtg cctttagcaa gacttaatca gaagtacttc    360

gtggggcaag aagccctgta caagtatgag gccctacatt tgcactaccc cattgagcgt    420

ggactggtaa caggatggga tgacatggag aaactctgga aacatctctt tgagcgggag    480

cttggagtaa aacccagcca acagcctgta cttatgaccg agccctcttt gaatcctagg    540

gaaattcgag aaaagctagc agaaatgatg tttgagacct tcagtgtgcc tggtttctac    600

ctgtctaatc atgcggtggc agcgctctat gcctctgcct gtgtcacagg cctggtggtg    660

gacagtggag atggggtcac ttgcactgtc cccatctttg agggttactc cctgcctcac    720

gcagtcacca aactctgtat ggcagggagg gacatcacag agcacctcac ccggctcctc    780

tttgctagcg ggtttaactt cccttgcata ctcaacaagg ccgtggtaaa taacatcaaa    840

gagaagttgt gctacatcgc cttggagcca gagaaagagc tacgcaagag ccggggagag    900

gtcctgggag catacagact gccagatgga catgtcatcc actttgggga tgagctgtac    960

caagtgcccg aggttctttt tgcacctgac cagctgggca tccacagccc aggactctca   1020

aaaatggtct ccagcagcat catgaagtgt gacactgaca tccagaataa actttatgca   1080

gacattgtac tctccggggg caccactctc ctccctgggc tggaggaaag gctcatgaag   1140

gaagtggaac agctggcttc caaaggtact cccatcaaga tcacagcttc tcctgataga   1200

tgcttctctg catggattgg tgcatccatc atgacctcta tgagcagttt caagcagatg   1260

tgggtcacct cggcagactt caaggagtat gggacatctg tggttcaaag aaggtgcttt   1320

taaagatcct tgagcagagg agacatcttg aagtgtcaga ttacaggagt accagtggga   1380

gatggcattt tcttctgggc ttcagcatga tgttcaataa aagttttgcc attccaaaaa   1440

aaaaaaaaaa a                                                        1451


<210>  1360
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  1360

Met Phe Asn Pro His Ala Leu Asp Val Pro Ala Val Ile Phe Asp Asn 
1               5                   10                  15


Gly Ser Gly Leu Cys Lys Ala Gly Leu Ser Gly Glu Ile Gly Pro Arg 
            20                  25                  30


His Val Ile Ser Ser Val Leu Gly His Cys Lys Phe Asn Val Pro Leu 
        35                  40                  45


Ala Arg Leu Asn Gln Lys Tyr Phe Val Gly Gln Glu Ala Leu Tyr Lys 
    50                  55                  60


Tyr Glu Ala Leu His Leu His Tyr Pro Ile Glu Arg Gly Leu Val Thr 
65                  70                  75                  80


Gly Trp Asp Asp Met Glu Lys Leu Trp Lys His Leu Phe Glu Arg Glu 
                85                  90                  95


Leu Gly Val Lys Pro Ser Gln Gln Pro Val Leu Met Thr Glu Pro Ser 
            100                 105                 110


Leu Asn Pro Arg Glu Ile Arg Glu Lys Leu Ala Glu Met Met Phe Glu 
        115                 120                 125


Thr Phe Ser Val Pro Gly Phe Tyr Leu Ser Asn His Ala Val Ala Ala 
    130                 135                 140


Leu Tyr Ala Ser Ala Cys Val Thr Gly Leu Val Val Asp Ser Gly Asp 
145                 150                 155                 160


Gly Val Thr Cys Thr Val Pro Ile Phe Glu Gly Tyr Ser Leu Pro His 
                165                 170                 175


Ala Val Thr Lys Leu Cys Met Ala Gly Arg Asp Ile Thr Glu His Leu 
            180                 185                 190


Thr Arg Leu Leu Phe Ala Ser Gly Phe Asn Phe Pro Cys Ile Leu Asn 
        195                 200                 205


Lys Ala Val Val Asn Asn Ile Lys Glu Lys Leu Cys Tyr Ile Ala Leu 
    210                 215                 220


Glu Pro Glu Lys Glu Leu Arg Lys Ser Arg Gly Glu Val Leu Gly Ala 
225                 230                 235                 240


Tyr Arg Leu Pro Asp Gly His Val Ile His Phe Gly Asp Glu Leu Tyr 
                245                 250                 255


Gln Val Pro Glu Val Leu Phe Ala Pro Asp Gln Leu Gly Ile His Ser 
            260                 265                 270


Pro Gly Leu Ser Lys Met Val Ser Ser Ser Ile Met Lys Cys Asp Thr 
        275                 280                 285


Asp Ile Gln Asn Lys Leu Tyr Ala Asp Ile Val Leu Ser Gly Gly Thr 
    290                 295                 300


Thr Leu Leu Pro Gly Leu Glu Glu Arg Leu Met Lys Glu Val Glu Gln 
305                 310                 315                 320


Leu Ala Ser Lys Gly Thr Pro Ile Lys Ile Thr Ala Ser Pro Asp Arg 
                325                 330                 335


Cys Phe Ser Ala Trp Ile Gly Ala Ser Ile Met Thr Ser Met Ser Ser 
            340                 345                 350


Phe Lys Gln Met Trp Val Thr Ser Ala Asp Phe Lys Glu Tyr Gly Thr 
        355                 360                 365


Ser Val Val Gln Arg Arg Cys Phe 
    370                 375


<210>  1361
<211>  1126
<212>  DNA
<213>  Homo sapiens

<400>  1361
atatatcaga ccatcagaag gatttgtata aagagtgact ctcctatgaa ggtaaaggcc     60

acccctcttc agttccagtg actgagatac atttttccaa tcctgggggc aaatacagac    120

acagcaagtt ccttcttccc tttggaaatt tggcagctgc cttcaccagt gagcacaaag    180

ccacatttca aaggaaactg acaaattatc cccagctgcc agaagaagaa atcctcactg    240

gacggcttcc tgtttcctgt ggttcattat ctgattggct gcagggatga aagtttttaa    300

gttcatagga ctgatgatcc tcctcacctc tgcgttttca gccggttcag gacaaagtcc    360

aatgactgtg ctgtgctcca tagactggtt catggtcaca gtgcacccct tcatgctaaa    420

caacgatgtg tgtgtacact ttcatgaact acacttgggc ctgggttgcc ccccaaacca    480

tgttcagcca cacgcctacc agttcaccta ccgtgttact gaatgtggca tcagggccaa    540

agctgtctct caggacatgg ttatctacag cactgagata cactactctt ctaagggcac    600

gccatctaag tttgtgatcc cagtgtcatg tgctgccccc caaaagtccc catggctcac    660

caagccctgc tccatgagag tagccagcaa gagcagggcc acagcccaga aggatgagaa    720

atgctacgag gtgttcagct tgtcacagtc cagtcaaagg cccaactgcg attgtccacc    780

ttgtgtcttc agtgaagaag agcataccca ggtcccttgt caccaagcag gggctcagga    840

ggctcaacct ctgcagccat ctcactttct tgatatttct gaggattggt ctcttcacac    900

agatgatatg attgggtcca tgtgatcctc aggtttgggg tctcctgaag atgctatttc    960

tagaattagt atatagtgta caaatgtctg acaaataagt gctcttgtga ccctcatgtg   1020

agcacttttg agaaagagaa acctatagca acttcatgaa ttaagccttt ttctatattt   1080

ttatattcat gtgtaaacaa aaaataaaat aaaattctga tcgcat                  1126


<210>  1362
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  1362

Met Lys Val Phe Lys Phe Ile Gly Leu Met Ile Leu Leu Thr Ser Ala 
1               5                   10                  15


Phe Ser Ala Gly Ser Gly Gln Ser Pro Met Thr Val Leu Cys Ser Ile 
            20                  25                  30


Asp Trp Phe Met Val Thr Val His Pro Phe Met Leu Asn Asn Asp Val 
        35                  40                  45


Cys Val His Phe His Glu Leu His Leu Gly Leu Gly Cys Pro Pro Asn 
    50                  55                  60


His Val Gln Pro His Ala Tyr Gln Phe Thr Tyr Arg Val Thr Glu Cys 
65                  70                  75                  80


Gly Ile Arg Ala Lys Ala Val Ser Gln Asp Met Val Ile Tyr Ser Thr 
                85                  90                  95


Glu Ile His Tyr Ser Ser Lys Gly Thr Pro Ser Lys Phe Val Ile Pro 
            100                 105                 110


Val Ser Cys Ala Ala Pro Gln Lys Ser Pro Trp Leu Thr Lys Pro Cys 
        115                 120                 125


Ser Met Arg Val Ala Ser Lys Ser Arg Ala Thr Ala Gln Lys Asp Glu 
    130                 135                 140


Lys Cys Tyr Glu Val Phe Ser Leu Ser Gln Ser Ser Gln Arg Pro Asn 
145                 150                 155                 160


Cys Asp Cys Pro Pro Cys Val Phe Ser Glu Glu Glu His Thr Gln Val 
                165                 170                 175


Pro Cys His Gln Ala Gly Ala Gln Glu Ala Gln Pro Leu Gln Pro Ser 
            180                 185                 190


His Phe Leu Asp Ile Ser Glu Asp Trp Ser Leu His Thr Asp Asp Met 
        195                 200                 205


Ile Gly Ser Met 
    210


<210>  1363
<211>  2380
<212>  DNA
<213>  Homo sapiens

<400>  1363
caggaccaga gacccctcca gcgggagtgc cacctgctgc ttcctcccag gtgtgggctg     60

caggaccagc tgcccaggaa tggctttctc gggacctcct gcaccggcct tccgacgcac    120

tggccaaagc acgtctatgg ctgcatcctc tgcccatggt ttcctccaaa gagtctggtc    180

cccaagaagt atcggtagac ccagctgggc ctgaggccct tctctttcac caccattctt    240

ccaaagagag ccccactctg atccccaacc atgttacctc ctcaaattca gaatatttcc    300

catagaaagc tgggccccca agagctccca cctgagggca gcccccctca tctgtcggcc    360

tggatcacgg cagcctccca gggccttgag acacagccaa aggaggcagc agagggtggg    420

gggtcagcag ctatgcacac aaatggaggg agggaaactg aggcacacca gaggactgga    480

gacccagagg tcacagtttc ctccagctct tctttttttt ttttttttga gatggggtct    540

tgctttgtca tccaggctgg agtccagtgg cacgatcttg gcttactgca gcctccacct    600

cccagattca ggcgatcctt ctgcctcagc ttcccgagta gctgggatta caggcccacg    660

ccaccacacc tggctaattt tgtattttta gtagagatgg ggtttcacca tgttggccag    720

gccagtctgg aactcctggc ctcaagtgat ccacccgcct tggcctccta ttgtgttggg    780

attacagtcg tgagccaccg cacccggtcc ctcgaaccca tctttgggtt gagattctca    840

gggcagccgg agcccatgtg ttcttgtttc taatgctttt tctctctcca cttctctctt    900

ggtgaagaag gggcttggac cattcctgca aacagccaaa ccggcgagaa gaggccagac    960

atctgcctcc attctcccca gagtggtgca agctcagcga ggtccccagc ctcccccagg   1020

ggaagcaggg atccctggac accccacacc tccagccacg ctcccctcgg agcctgtaga   1080

gggtgtccag gctagtccct ggcggccacg tccagtcttg ccaacgcacc cggctctgac   1140

cctgcccgtg tcctcagatg cctcctctcc ttcaccgcca gccccgaggc ctgaacgacc   1200

tgaatcactt ctggtctcag gaccatctgt caccctgact gaaggtctag gaactgtgag   1260

gcctgaacag gaccccgcca agtctccagg aagtcccctc ctgctgagag gcttgtcaag   1320

cggggatgtg gctgcacctg agcccatcat gggggagccc ggccaagcca gtgaggagtt   1380

ccagccattg gcgaggccct ggcgggccac actggctgca gaggagctgg tttctcaccg   1440

ttctcccgga gagccccagg aaacgtgctc tggaacggag gtggagaggc cacgccagac   1500

agggcctggt ctccccaggg agggggccag ggggcacatg gacctttcat cctcagaacc   1560

aagccaggac atagaggggc cgggactctc catcctgcca gcgagggatg ccacattctc   1620

caccccaagt gtgaggcagc cagaccccag tgcctggctg agttcaggac ctgaactcac   1680

cgggatgccc agggtgaggc tggcagcgcc cctggcagtt cttcctatgg aacctctgcc   1740

accagaacct gttcgcccag cagctcttct gacacccgaa gcctcatctg tgggagggcc   1800

agaccaggcc cgatacctgg agtcagcccc tggctggcct gtgggccagg aggagtgggg   1860

ggttgcacac acgtccagcc ctccatccac gcaaaccctg agcctgtggg ctcccacagg   1920

agtgttgcta cccagcctgg tggagcttga ataccccttc caggctggcc ggggggcctc   1980

actccagcag gagctgacag agcccacctt ggccctcagt gctgaaagcc acaggcctcc   2040

tgagcttcaa gacagtgtgg aggggctttc tgagaggccc tcacgctgag cctccatgga   2100

gactccaggc agccggtacc ccgctggctt ggacagcccc agtgaccctc agtgacccag   2160

ctgtccccag gctccctggc ttagatgccc agctgtggct gggtacagtg ttctgggccg   2220

gaagagcact cactcagtgc ttccctggaa aggtggaccc ccagacgccc acctccaggc   2280

agacccatca ctggaagtgg gatttgaaat gcagccaaga agaggagacc gtcggcaacg   2340

cccgcccgga acaagaaata aataaataaa taatcagggt                         2380


<210>  1364
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  1364

Met Gly Glu Pro Gly Gln Ala Ser Glu Glu Phe Gln Pro Leu Ala Arg 
1               5                   10                  15


Pro Trp Arg Ala Thr Leu Ala Ala Glu Glu Leu Val Ser His Arg Ser 
            20                  25                  30


Pro Gly Glu Pro Gln Glu Thr Cys Ser Gly Thr Glu Val Glu Arg Pro 
        35                  40                  45


Arg Gln Thr Gly Pro Gly Leu Pro Arg Glu Gly Ala Arg Gly His Met 
    50                  55                  60


Asp Leu Ser Ser Ser Glu Pro Ser Gln Asp Ile Glu Gly Pro Gly Leu 
65                  70                  75                  80


Ser Ile Leu Pro Ala Arg Asp Ala Thr Phe Ser Thr Pro Ser Val Arg 
                85                  90                  95


Gln Pro Asp Pro Ser Ala Trp Leu Ser Ser Gly Pro Glu Leu Thr Gly 
            100                 105                 110


Met Pro Arg Val Arg Leu Ala Ala Pro Leu Ala Val Leu Pro Met Glu 
        115                 120                 125


Pro Leu Pro Pro Glu Pro Val Arg Pro Ala Ala Leu Leu Thr Pro Glu 
    130                 135                 140


Ala Ser Ser Val Gly Gly Pro Asp Gln Ala Arg Tyr Leu Glu Ser Ala 
145                 150                 155                 160


Pro Gly Trp Pro Val Gly Gln Glu Glu Trp Gly Val Ala His Thr Ser 
                165                 170                 175


Ser Pro Pro Ser Thr Gln Thr Leu Ser Leu Trp Ala Pro Thr Gly Val 
            180                 185                 190


Leu Leu Pro Ser Leu Val Glu Leu Glu Tyr Pro Phe Gln Ala Gly Arg 
        195                 200                 205


Gly Ala Ser Leu Gln Gln Glu Leu Thr Glu Pro Thr Leu Ala Leu Ser 
    210                 215                 220


Ala Glu Ser His Arg Pro Pro Glu Leu Gln Asp Ser Val Glu Gly Leu 
225                 230                 235                 240


Ser Glu Arg Pro Ser Arg 
                245


<210>  1365
<211>  2267
<212>  DNA
<213>  Homo sapiens

<400>  1365
acataatgaa gtgtccgatg ctaaggtcaa ggctgggcca ggaaagcgtc cactgtgggc     60

ccatgttcat ccaggtctcc cggcccctgc ccctgtggag ggacaataga cagactccat    120

ggctgctgtc ccttcgaggg gagctggtgg cttctcttga agacgccagc ctgatgggac    180

tgtatgtgga catgaatgcc accactgtca ccgtccaaag cccgagacaa ggccttcttc    240

agaggtggga ggtcagtggt gggcagcagg ctctgccagg agtgtcattc cagccagagt    300

cggaggtctt agttcacatc cccaagcaga gactgggtct agtcaaaaga ggttcctaca    360

ttgaggaaac cctgagcctc agattcctcc gagtccacca gtccaacatc tttatggtga    420

ctgagaacaa ggactttgtg gtggtcagca ttccggcggc cggggtgctc caggtccagc    480

gatgccaaga agtcggagga accccgggaa cacaagcttt ctatagggta gacctgagcc    540

tggaatttgc cgagatggct gccccggtcc tctggacagt ggagagcttc ttccagtgtg    600

tgggttcagg aacagagtcg cctgcctcaa ctgctgcact gaggaccact ccctccccac    660

catccccagg accagagacc cctccagcgg gagtgccacc tgctgcttcc tcccaggtgt    720

gggctgcagg accagctgcc caggaatggc tttctcggga cctcctgcac cggccttccg    780

acgcactggc caaaaagggg cttggaccat tcctgcaaac agccaaaccg gcgagaagag    840

gccagacatc tgcctccatt ctccccagag tggtgcaagc tcagcgaggt ccccagcctc    900

ccccagggga agcagggatc cctggacacc ccacacctcc agccacgctc ccctcggagc    960

ctgtagaggg tgtccaggct agtccctggc ggccacgtcc agtcttgcca acgcacccgg   1020

ctctgaccct gcccgtgtcc tcagatgcct cctctccttc accgccagcc ccgaggcctg   1080

aacgacctga atcacttctg gtctcaggac catctgtcac cctgactgaa ggtctaggaa   1140

ctgtgaggcc tgaacaggac cccgccaagt ctccaggaag tcccctcctg ctgagaggct   1200

tgtcaagcgg ggatgtggct gcacctgagc ccatcatggg ggagcccggc caagccagtg   1260

aggagttcca gccattggcg aggccctggc gggccacact ggctgcagag gagctggttt   1320

ctcaccgttc tcccggagag ccccaggaaa cgtgctctgg aacggaggtg gagaggccac   1380

gccagacagg gcctggtctc cccagggagg gggccagggg gcacatggac ctttcatcct   1440

cagaaccaag ccaggacata gaggggccgg gactctccat cctgccagcg agggatgcca   1500

cattctccac cccaagtgtg aggcagccag accccagtgc ctggctgagt tcaggacctg   1560

aactcaccgg gatgcccagg gtgaggctgg cagcgcccct ggcagttctt cctatggaac   1620

ctctgccacc agaacctgtt cgcccagcag ctcttctgac acccgaagcc tcatctgtgg   1680

gagggccaga ccaggcccga tacctggagt cagcccctgg ctggcctgtg ggccaggagg   1740

agtggggggt tgcacacacg tccagccctc catccacgca aaccctgagc ctgtgggctc   1800

ccacaggagt gttgctaccc agcctggtgg agcttgaata ccccttccag gctggccggg   1860

gggcctcact ccagcaggag ctgacagagc ccaccttggc cctcagtgct gaaagccaca   1920

ggcctcctga gcttcaagac agtgtggagg ggctttctga gaggccctca cgctgagcct   1980

ccatggagac tccaggcagc cggtaccccg ctggcttgga cagccccagt gaccctcagt   2040

gacccagctg tccccaggct ccctggctta gatgcccagc tgtggctggg tacagtgttc   2100

tgggccggaa gagcactcac tcagtgcttc cctggaaagg tggaccccca gacgcccacc   2160

tccaggcaga cccatcactg gaagtgggat ttgaaatgca gccaagaaga ggagaccgtc   2220

ggcaacgccc gcccggaaca agaaataaat aaataaataa tcagggt                 2267


<210>  1366
<211>  656
<212>  PRT
<213>  Homo sapiens

<400>  1366

Met Lys Cys Pro Met Leu Arg Ser Arg Leu Gly Gln Glu Ser Val His 
1               5                   10                  15


Cys Gly Pro Met Phe Ile Gln Val Ser Arg Pro Leu Pro Leu Trp Arg 
            20                  25                  30


Asp Asn Arg Gln Thr Pro Trp Leu Leu Ser Leu Arg Gly Glu Leu Val 
        35                  40                  45


Ala Ser Leu Glu Asp Ala Ser Leu Met Gly Leu Tyr Val Asp Met Asn 
    50                  55                  60


Ala Thr Thr Val Thr Val Gln Ser Pro Arg Gln Gly Leu Leu Gln Arg 
65                  70                  75                  80


Trp Glu Val Ser Gly Gly Gln Gln Ala Leu Pro Gly Val Ser Phe Gln 
                85                  90                  95


Pro Glu Ser Glu Val Leu Val His Ile Pro Lys Gln Arg Leu Gly Leu 
            100                 105                 110


Val Lys Arg Gly Ser Tyr Ile Glu Glu Thr Leu Ser Leu Arg Phe Leu 
        115                 120                 125


Arg Val His Gln Ser Asn Ile Phe Met Val Thr Glu Asn Lys Asp Phe 
    130                 135                 140


Val Val Val Ser Ile Pro Ala Ala Gly Val Leu Gln Val Gln Arg Cys 
145                 150                 155                 160


Gln Glu Val Gly Gly Thr Pro Gly Thr Gln Ala Phe Tyr Arg Val Asp 
                165                 170                 175


Leu Ser Leu Glu Phe Ala Glu Met Ala Ala Pro Val Leu Trp Thr Val 
            180                 185                 190


Glu Ser Phe Phe Gln Cys Val Gly Ser Gly Thr Glu Ser Pro Ala Ser 
        195                 200                 205


Thr Ala Ala Leu Arg Thr Thr Pro Ser Pro Pro Ser Pro Gly Pro Glu 
    210                 215                 220


Thr Pro Pro Ala Gly Val Pro Pro Ala Ala Ser Ser Gln Val Trp Ala 
225                 230                 235                 240


Ala Gly Pro Ala Ala Gln Glu Trp Leu Ser Arg Asp Leu Leu His Arg 
                245                 250                 255


Pro Ser Asp Ala Leu Ala Lys Lys Gly Leu Gly Pro Phe Leu Gln Thr 
            260                 265                 270


Ala Lys Pro Ala Arg Arg Gly Gln Thr Ser Ala Ser Ile Leu Pro Arg 
        275                 280                 285


Val Val Gln Ala Gln Arg Gly Pro Gln Pro Pro Pro Gly Glu Ala Gly 
    290                 295                 300


Ile Pro Gly His Pro Thr Pro Pro Ala Thr Leu Pro Ser Glu Pro Val 
305                 310                 315                 320


Glu Gly Val Gln Ala Ser Pro Trp Arg Pro Arg Pro Val Leu Pro Thr 
                325                 330                 335


His Pro Ala Leu Thr Leu Pro Val Ser Ser Asp Ala Ser Ser Pro Ser 
            340                 345                 350


Pro Pro Ala Pro Arg Pro Glu Arg Pro Glu Ser Leu Leu Val Ser Gly 
        355                 360                 365


Pro Ser Val Thr Leu Thr Glu Gly Leu Gly Thr Val Arg Pro Glu Gln 
    370                 375                 380


Asp Pro Ala Lys Ser Pro Gly Ser Pro Leu Leu Leu Arg Gly Leu Ser 
385                 390                 395                 400


Ser Gly Asp Val Ala Ala Pro Glu Pro Ile Met Gly Glu Pro Gly Gln 
                405                 410                 415


Ala Ser Glu Glu Phe Gln Pro Leu Ala Arg Pro Trp Arg Ala Thr Leu 
            420                 425                 430


Ala Ala Glu Glu Leu Val Ser His Arg Ser Pro Gly Glu Pro Gln Glu 
        435                 440                 445


Thr Cys Ser Gly Thr Glu Val Glu Arg Pro Arg Gln Thr Gly Pro Gly 
    450                 455                 460


Leu Pro Arg Glu Gly Ala Arg Gly His Met Asp Leu Ser Ser Ser Glu 
465                 470                 475                 480


Pro Ser Gln Asp Ile Glu Gly Pro Gly Leu Ser Ile Leu Pro Ala Arg 
                485                 490                 495


Asp Ala Thr Phe Ser Thr Pro Ser Val Arg Gln Pro Asp Pro Ser Ala 
            500                 505                 510


Trp Leu Ser Ser Gly Pro Glu Leu Thr Gly Met Pro Arg Val Arg Leu 
        515                 520                 525


Ala Ala Pro Leu Ala Val Leu Pro Met Glu Pro Leu Pro Pro Glu Pro 
    530                 535                 540


Val Arg Pro Ala Ala Leu Leu Thr Pro Glu Ala Ser Ser Val Gly Gly 
545                 550                 555                 560


Pro Asp Gln Ala Arg Tyr Leu Glu Ser Ala Pro Gly Trp Pro Val Gly 
                565                 570                 575


Gln Glu Glu Trp Gly Val Ala His Thr Ser Ser Pro Pro Ser Thr Gln 
            580                 585                 590


Thr Leu Ser Leu Trp Ala Pro Thr Gly Val Leu Leu Pro Ser Leu Val 
        595                 600                 605


Glu Leu Glu Tyr Pro Phe Gln Ala Gly Arg Gly Ala Ser Leu Gln Gln 
    610                 615                 620


Glu Leu Thr Glu Pro Thr Leu Ala Leu Ser Ala Glu Ser His Arg Pro 
625                 630                 635                 640


Pro Glu Leu Gln Asp Ser Val Glu Gly Leu Ser Glu Arg Pro Ser Arg 
                645                 650                 655


<210>  1367
<211>  786
<212>  DNA
<213>  Homo sapiens

<400>  1367
tcaccgttct cccggagagc cccaggaaac gtgctctgga acggaggtgg agaggccacg     60

ccagacaggg cctggtctcc ccagggaggg ggccaggggg cacatggacc tttcatcctc    120

agaaccaagc caggacatag aggggccggg actctccatc ctgccagcga gggatgccac    180

attctccacc ccaagtgtga ggcagccaga ccccagtgcc tggctgagtt caggacctga    240

actcaccggg atgcccaggg tgaggctggc agcgcccctg gcagttcttc ctatggaacc    300

tctgccacca gaacctgttc gcccagcagc tcttctgaca cccgaagcct catctgtggg    360

agggccagac caggcccgat acctggagtc agcccctggc tggcctgtgg gccaggagga    420

gtggggggtt gcacacacgt ccagccctcc atccacgcaa accctgagcc tgtgggctcc    480

cacaggagtg ttgctaccca gcctggtgga gcttgaatac cccttccagg ctggccgggg    540

ggcctcactc cagcaggagc tgacagagcc caccttggcc ctcagtgctg aaagccacag    600

gcctcctgag cttcaagaca gtgtggaggg gctttctgag aggccctcac gctgagcctc    660

catggagact ccaggacgcc cacctccagg cagacccatc actggaagtg ggatttgaaa    720

tgcagccaag aagaggagac cgtcggcaac gcccgcccgg aacaagaaat aaataaataa    780

ataatc                                                               786


<210>  1368
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  1368

Met Asp Leu Ser Ser Ser Glu Pro Ser Gln Asp Ile Glu Gly Pro Gly 
1               5                   10                  15


Leu Ser Ile Leu Pro Ala Arg Asp Ala Thr Phe Ser Thr Pro Ser Val 
            20                  25                  30


Arg Gln Pro Asp Pro Ser Ala Trp Leu Ser Ser Gly Pro Glu Leu Thr 
        35                  40                  45


Gly Met Pro Arg Val Arg Leu Ala Ala Pro Leu Ala Val Leu Pro Met 
    50                  55                  60


Glu Pro Leu Pro Pro Glu Pro Val Arg Pro Ala Ala Leu Leu Thr Pro 
65                  70                  75                  80


Glu Ala Ser Ser Val Gly Gly Pro Asp Gln Ala Arg Tyr Leu Glu Ser 
                85                  90                  95


Ala Pro Gly Trp Pro Val Gly Gln Glu Glu Trp Gly Val Ala His Thr 
            100                 105                 110


Ser Ser Pro Pro Ser Thr Gln Thr Leu Ser Leu Trp Ala Pro Thr Gly 
        115                 120                 125


Val Leu Leu Pro Ser Leu Val Glu Leu Glu Tyr Pro Phe Gln Ala Gly 
    130                 135                 140


Arg Gly Ala Ser Leu Gln Gln Glu Leu Thr Glu Pro Thr Leu Ala Leu 
145                 150                 155                 160


Ser Ala Glu Ser His Arg Pro Pro Glu Leu Gln Asp Ser Val Glu Gly 
                165                 170                 175


Leu Ser Glu Arg Pro Ser Arg 
            180


<210>  1369
<211>  464
<212>  DNA
<213>  Homo sapiens

<400>  1369
agaaaggggt gatggggttg gagcggagtg atcgctacat aatgaagtgt ccgatgctaa     60

ggtcaaggct gggccaggaa agcgtccact gtgggcccat gttcatccag gtctcccggc    120

ccctgcccct gtggagggac aatagacaga ctccatggct gctgtccctt cgaggggagc    180

tggtggcttc tcttgaagac gccagcctga tgggactgta tgtggacatg aatgccacca    240

ctgtcaccgt ccaaagcccg agacaaggcc ttcttcagag gtgggaggtc agtggtgggc    300

agcaggctct gccaggaggt gaggggcctc tggggcatag cacctagaag agcaggttgc    360

cacccctcca gtgacaagtc aaatgtccac ctgcgagact ggacagattt aggcaggcgc    420

cttcgaaaat tgggccccat tagcgtaaag cgctccgctc tgca                     464


<210>  1370
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  1370

Met Gly Leu Glu Arg Ser Asp Arg Tyr Ile Met Lys Cys Pro Met Leu 
1               5                   10                  15


Arg Ser Arg Leu Gly Gln Glu Ser Val His Cys Gly Pro Met Phe Ile 
            20                  25                  30


Gln Val Ser Arg Pro Leu Pro Leu Trp Arg Asp Asn Arg Gln Thr Pro 
        35                  40                  45


Trp Leu Leu Ser Leu Arg Gly Glu Leu Val Ala Ser Leu Glu Asp Ala 
    50                  55                  60


Ser Leu Met Gly Leu Tyr Val Asp Met Asn Ala Thr Thr Val Thr Val 
65                  70                  75                  80


Gln Ser Pro Arg Gln Gly Leu Leu Gln Arg Trp Glu Val Ser Gly Gly 
                85                  90                  95


Gln Gln Ala Leu Pro Gly Gly Glu Gly Pro Leu Gly His Ser Thr 
            100                 105                 110


<210>  1371
<211>  4216
<212>  DNA
<213>  Homo sapiens

<400>  1371
ggtgggcggg gggaggaggc ggccctagcg ccattttgtg ggagcgaagc ggtggctggg     60

ctgcgcttgg gtccgtcgct gcttcggtgt ccctgtcggg cttcccagca gcggcctagc    120

gggaaaagta aaagatgtct gaatatattc gggtaaccga agatgagaac gatgagccca    180

ttgaaatacc atcggaagac gatgggacgg tgctgctctc cacggttaca gcccagtttc    240

caggggcgtg tgggcttcgc tacaggaatc cagtgtctca gtgtatgaga ggtgtccggc    300

tggtagaagg aattctgcat gccccagatg ctggctgggg aaatctggtg tatgttgtca    360

actatccaaa agataacaaa agaaaaatgg atgagacaga tgcttcatca gcagtgaaag    420

tgaaaagagc agtccagaaa acatccgatt taatagtgtt gggtctccca tggaaaacaa    480

ccgaacagga cctgaaagag tattttagta cctttggaga agttcttatg gtgcaggtca    540

agaaagatct taagactggt cattcaaagg ggtttggctt tgttcgtttt acggaatatg    600

aaacacaagt gaaagtaatg tcacagcgac atatgataga tggacgatgg tgtgactgca    660

aacttcctaa ttctaagcaa agccaagatg agcctttgag aagcagaaaa gtgtttgtgg    720

ggcgctgtac agaggacatg actgaggatg agctgcggga gttcttctct cagtacgggg    780

atgtgatgga tgtcttcatc cccaagccat tcagggcctt tgcctttgtt acatttgcag    840

atgatcagat tgcgcagtct ctttgtggag aggacttgat cattaaagga atcagcgttc    900

atatatccaa tgccgaacct aagcacaata gcaatagaca gttagaaaga agtggaagat    960

ttggtggtaa tccaggtggc tttgggaatc agggtggatt tggtaatagc agagggggtg   1020

gagctggttt gggaaacaat caaggtagta atatgggtgg tgggatgaac tttggtgcgt   1080

tcagcattaa tccagccatg atggctgccg cccaggcagc actacagagc agttggggta   1140

tgatgggcat gttagccagc cagcagaacc agtcaggccc atcgggtaat aaccaaaacc   1200

aaggcaacat gcagagggag ccaaaccagg ccttcggttc tggaaataac tcttatagtg   1260

gctctaattc tggtgcagca attggttggg gatcagcatc caatgcaggg tcgggcagtg   1320

gttttaatgg aggctttggc tcaagcatgg attctaagtc ttctggctgg ggaatgtaga   1380

cagtggggtt gtggttggtt ggtatagaat ggtgggaatt caaatttttc taaactcatg   1440

gtaagtatat tgtaaaatac atatgtacta agaattttca aaattggttt gttcagtgtg   1500

gagtatattc agcagtattt ttgacatttt tctttagaaa aaggaagagc taaaggaatt   1560

ttataagttt tgttacatga aaggttgaaa tattgagtgg ttgaaagtga actgctgttt   1620

gcctgattgg taaaccaaca cactacaatt gatatcaaaa ggtttctcct gtaatatttt   1680

atccctggac ttgtcaagtg aattctttgc atgttcaaaa cggaaaccat tgattagaac   1740

tacattcttt accccttgtt ttaatttgaa ccccaccata tggatttttt tccttaagaa   1800

aatctccttt taggagatca tggtgtcaca gtgtttggtt cttttgtttt gttttttaac   1860

acttgtctcc cctcatacac aaaagtacaa tatgaagcct tcatttaatc tctgcagttc   1920

atctcatttc aaatgtttat ggaagaagca cttcattgaa agtagtgctg taaatattct   1980

gccataggaa tactgtctac atgctttctc attcaagaat tcgtcatcac gcatcacagg   2040

ccgcgtcttt gacggtgggt gtcccatttt tatccgctac tctttatttc atggagtcgt   2100

atcaacgcta tgaacgcaag gctgtgatat ggaaccagaa ggctgtctga acttttgaaa   2160

ccttgtgtgg gattgatggt ggtgccgagg catgaaaggc tagtatgagc gagaaaagga   2220

gagagcgcgt gcagagactt ggtggtgcat aatggatatt ttttaacttg gcgagatgtg   2280

tctctcaatc ctgtggcttt ggtgagagag tgtgcagaga gcaatgatag caaataatgt   2340

acgaatgttt tttgcattca aaggacatcc acatctgttg gaagactttt aagtgagttt   2400

ttgttcttag ataacccaca ttagatgaat gtgttaagtg aaatgatact tgtactcccc   2460

ctaccccttt gtcaactgct gtgaatgctg tatggtgtgt gttctcttct gttactgata   2520

tgtaagtgtg gcaatgtgaa ctgaagctga tgggctgaga acatggactg agcttgtggt   2580

gtgctttgca ggaggacttg aagcagagtt caccagtgag ctcaggtgtc tcaaagaagg   2640

gtggaagttc taatgtctgt tagctaccca taagaatgct gtttgctgca gttctgtgtc   2700

ctgtgcttgg atgcttttta taagagttgt cattgttgga aattcttaaa taaaactgat   2760

ttaaataata tgtgtctttg ttttgcagcc ctgaatgcaa agaattcata gcagttaatt   2820

cccctttttt gacccttttg agatggaact ttcataaagt ttcttggcag tagtttattt   2880

tgcttcaaat aaacttattt gaaaagttgt ctcaagtcaa atggattcat cacctgtcat   2940

gcattgacac ctgataccca gacttaattg gtatttgttc ttgcattggc caaagtgaaa   3000

attttttttt ttcttttgaa atctagtttt gaataagtct gggtgaccgc acctaaaatg   3060

gtaagcagta ccctccggct ttttcttagt gcctctgtgc atttgggtga tgttctattt   3120

acatggcctg tgtaaatctc cattgggaag tcatgccttc taaaaagatt cttatttggg   3180

ggagtgggca aaatgttgat tattttctaa tgctttgtag caaagcatat caattgaaaa   3240

gggaatatca gcaccttcct agtttgggat ttgaaaagtg gaattaattg cagtagggat   3300

aaagtagaag aaaccacaaa ttatcttgtg cctgaaatcc attaagaggc ctgatagctt   3360

taagaattag ggtgggttgt ctgtctggaa gtgttaagtg gaatgggctt tgtcctccag   3420

gaggtggggg aatgtggtaa cattgaatac agttgaataa aatcgcttac aaaactcaca   3480

ctctcacaat gcattgttaa gtatgtaaaa gcaataacat tgattctctg ttgtactttt   3540

ttgtaactaa ttctgtgaga gttgagctca ttttctagtt ggaagaatgt gatatttgtt   3600

gtgttggtag tttacctaat gcccttacct aattagatta tgataaatag gtttgtcatt   3660

ttgcaagtta cataaacatt tatcaatgaa gtcatccttt agacttgtaa tcgccacatt   3720

gtttcattat tcagtttcct ctgtaaaggg atcttgagtt gttttaattt tttttttctg   3780

catctgaatc tgcatgattt ccaaaccctg taccatctga attttgcatt ttagcacttg   3840

cactattact cagcagcagt aacatggtaa cacttaaaat ggtactcggg gacctccaaa   3900

gactaaactg acaagccttc aaggagccca ggggtaagtt aacttgtcaa cggcatggtt   3960

taatcccttc tttacacttg tgtaaatttc agttactggt catagaaggc tttcaatgtt   4020

gagtggcctt ttattaacat gtttatggta ctgcatagat acgggtattt attttaccct   4080

aagaagattt tgaagtttaa aagtacttaa actatttggc aaagatttgt ttttaaaaat   4140

ctatttggtc aatctaaatg cattcattct aaaaaatttt ttgaaccaga taaataaaat   4200

ttttttttga caccac                                                   4216


<210>  1372
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  1372

Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
1               5                   10                  15


Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            20                  25                  30


Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        35                  40                  45


Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    50                  55                  60


Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Asp 
65                  70                  75                  80


Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser Ala Val Lys Val 
                85                  90                  95


Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val Leu Gly Leu Pro 
            100                 105                 110


Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly 
        115                 120                 125


Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys Thr Gly His Ser 
    130                 135                 140


Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu Thr Gln Val Lys 
145                 150                 155                 160


Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp Cys Asp Cys Lys 
                165                 170                 175


Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu Arg Ser Arg Lys 
            180                 185                 190


Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp Glu Leu Arg 
        195                 200                 205


Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe Ile Pro Lys 
    210                 215                 220


Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp Gln Ile Ala 
225                 230                 235                 240


Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile Ser Val His 
                245                 250                 255


Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln Leu Glu Arg 
            260                 265                 270


Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly 
        275                 280                 285


Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly 
    290                 295                 300


Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro 
305                 310                 315                 320


Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met 
                325                 330                 335


Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn 
            340                 345                 350


Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly 
        355                 360                 365


Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly 
    370                 375                 380


Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly 
385                 390                 395                 400


Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
                405                 410


<210>  1373
<211>  608
<212>  DNA
<213>  Homo sapiens

<400>  1373
gggggaggag gcggccctag cgccattttg tgggagcgaa gcggtggctg ggctgcgctt     60

gggtccgtcg ctgcttcggt gtccctgtcg ggcttcccag cagcggccta gcgggaaaag    120

taaaagatgt ctgaatatat tcgggtaacc gaagatgaga acgatgagcc cattgaaata    180

ccatcggaag acgatgggac ggtgctgctc tccacggtta cagcccagtt tccaggggcg    240

tgtgggcttc gctacaggaa tccagtgtct cagtgtatga gaggtgtccg gctggtagaa    300

ggaattctgc atgccccaga tgctggctgg ggaaatctgg tgtatgttgt caactatcca    360

aaagataaca aaagaaaaat ggatgagaca gatgcttcat cagcagtgaa agtgaaaaga    420

gcagtccaga aaacatccga tttaatagtg ttgggtctcc catggaaaac aaccgaacag    480

gacctgaaag agtattttag tacctttgga gaagttctta tggtgcagag acagggtttt    540

gctgtgttgc ccaggctggt cctgaactcc tgtgctcaag cgatccaccc tcctcagcat    600

cccaaagc                                                             608


<210>  1374
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  1374

Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
1               5                   10                  15


Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            20                  25                  30


Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        35                  40                  45


Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    50                  55                  60


Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Asp 
65                  70                  75                  80


Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser Ala Val Lys Val 
                85                  90                  95


Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val Leu Gly Leu Pro 
            100                 105                 110


Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly 
        115                 120                 125


Glu Val Leu Met Val Gln Arg Gln Gly Phe Ala Val Leu Pro Arg Leu 
    130                 135                 140


Val Leu Asn Ser Cys Ala Gln Ala Ile His Pro Pro Gln His Pro 
145                 150                 155


<210>  1375
<211>  2761
<212>  DNA
<213>  Homo sapiens

<400>  1375
gggggaggag gcggccctag cgccattttg tgggagcgaa gcggtggctg ggctgcgctt     60

gggtccgtcg ctgcttcggt gtccctgtcg ggcttcccag cagcggccta gcgggaaaag    120

taaaagatgt ctgaatatat tcgggtaacc gaagatgaga acgatgagcc cattgaaata    180

ccatcggaag acgatgggac ggtgctgctc tccacggtta cagcccagtt tccaggggcg    240

tgtgggcttc gctacaggaa tccagtgtct cagtgtatga gaggtgtccg gctggtagaa    300

ggaattctgc atgccccaga tgctggctgg ggaaatctgg tgtatgttgt caactatcca    360

aaagataaca aaagaaaaat ggatgagaca gatgcttcat cagcagtgaa agtgaaaaga    420

gcagtccaga aaacatccga tttaatagtg ttgggtctcc catggaaaac aaccgaacag    480

gacctgaaag agtattttag tacctttgga gaagttctta tggtgcaggt caagaaagat    540

cttaagactg gtcattcaaa ggggtttggc tttgttcgtt ttacggaata tgaaacacaa    600

gtgaaagtaa tgtcacagcg acatatgata gatggacgat ggtgtgactg caaacttcct    660

aattctaagc aaagccaaga tgagcctttg agaagcagaa aagtgtttgt ggggcgctgt    720

acagaggaca tgactgagga tgagctgcgg gagttcttct ctcagtacgg ggatgtgatg    780

gatgtcttca tccccaagcc attcagggcc tttgcctttg ttacatttgc agatgatcag    840

attgcgcagt ctctttgtgg agaggacttg atcattaaag gaatcagcgt tcatatatcc    900

aatgccgaac ctaagcacaa tagcaataga cagttagaaa gaagtggaag atttggtggt    960

aatccaggtg gctttgggaa tcagggtgga tttggtaata gcagaggggg tggagctggt   1020

ttgggaaaca atcaaggtag taatatgggt ggtgggatga actttggtgc gttcagcatt   1080

aatccagcca tgatggctgc cgcccaggca gcactacaga gcagttgggg tatgatgggc   1140

atgttagcca gccagcagaa ccagtcaggc ccatcgggta ataaccaaaa ccaaggcaac   1200

atgcagaggg agccaaacca ggccttcggt tctggaaata actcttatag tggctctaat   1260

tctggtgcag caattggttg gggatcagca tccaatgcag ggtcgggcag tggttttaat   1320

ggaggctttg gctcaagcat ggattctaag tcttctggct ggggaatgta gacagtgggg   1380

ttgtggttgg ttggtataga atggtgggaa ttcaaatttt tctaaactca tggtaagtat   1440

attgtaaaat acatatgtac taagaatttt caaaattggt ttgttcagtg tggagtatat   1500

tcagcagtat ttttgacatt tttctttaga aaaaggaaga gctaaaggaa ttttataagt   1560

tttgttacat gaaaggttga aatattgagt ggttgaaagt gaactgctgt ttgcctgatt   1620

ggtaaaccaa cacactacaa ttgatatcaa aaggtttctc ctgtaatatt ttatccctgg   1680

acttgtcaag tgaattcttt gcatgttcaa aacggaaacc attgattaga actacattct   1740

ttaccccttg ttttaatttg aaccccacca tatggatttt tttccttaag aaaatctcct   1800

tttaggagat catggtgtca cagtgtttgg ttcttttgtt ttgtttttta acacttgtct   1860

cccctcatac acaaaagtac aatatgaagc cttcatttaa tctctgcagt tcatctcatt   1920

tcaaatgttt atggaagaag cacttcattg aaagtagtgc tgtaaatatt ctgccatagg   1980

aatactgtct acatgctttc tcattcaaga attcgtcatc acgcatcaca ggccgcgtct   2040

ttgacggtgg gtgtcccatt tttatccgct actctttatt tcatggagtc gtatcaacgc   2100

tatgaacgca aggctgtgat atggaaccag aaggctgtct gaacttttga aaccttgtgt   2160

gggattgatg gtggtgccga ggcatgaaag gctagtatga gcgagaaaag gagagagcgc   2220

gtgcagagac ttggtggtgc ataatggata ttttttaact tggcgagatg tgtctctcaa   2280

tcctgtggct ttggtgagag agtgtgcaga gagcaatgat agcaaataat gtacgaatgt   2340

tttttgcatt caaaggacat ccacatctgt tggaagactt ttaagtgagt ttttgttctt   2400

agataaccca cattagatga atgtgttaag tgaaatgata cttgtactcc ccctacccct   2460

ttgtcaactg ctgtgaatgc tgtatggtgt gtgttctctt ctgttactga tatgtaagtg   2520

tggcaatgtg aactgaagct gatgggctga gaacatggac tgagcttgtg gtgtgctttg   2580

caggaggact tgaagcagag ttcaccagtg agctcaggtg tctcaaagaa gggtggaagt   2640

tctaatgtct gttagctacc cataagaatg ctgtttgctg cagttctgtg tcctgtgctt   2700

ggatgctttt tataagagtt gtcattgttg gaaattctta aataaaactg atttaaataa   2760

t                                                                   2761


<210>  1376
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  1376

Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
1               5                   10                  15


Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            20                  25                  30


Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        35                  40                  45


Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    50                  55                  60


Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Asp 
65                  70                  75                  80


Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser Ala Val Lys Val 
                85                  90                  95


Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val Leu Gly Leu Pro 
            100                 105                 110


Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly 
        115                 120                 125


Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys Thr Gly His Ser 
    130                 135                 140


Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu Thr Gln Val Lys 
145                 150                 155                 160


Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp Cys Asp Cys Lys 
                165                 170                 175


Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu Arg Ser Arg Lys 
            180                 185                 190


Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp Glu Leu Arg 
        195                 200                 205


Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe Ile Pro Lys 
    210                 215                 220


Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp Gln Ile Ala 
225                 230                 235                 240


Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile Ser Val His 
                245                 250                 255


Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln Leu Glu Arg 
            260                 265                 270


Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly 
        275                 280                 285


Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly 
    290                 295                 300


Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro 
305                 310                 315                 320


Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met 
                325                 330                 335


Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn 
            340                 345                 350


Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly 
        355                 360                 365


Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly 
    370                 375                 380


Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly 
385                 390                 395                 400


Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
                405                 410


<210>  1377
<211>  2901
<212>  DNA
<213>  Homo sapiens

<400>  1377
gggggaggag gcggccctag cgccattttg tgggagcgaa gcggtggctg ggctgcgctt     60

gggtccgtcg ctgcttcggt gtccctgtcg ggcttcccag cagcggccta gcgggaaaag    120

taaaagatgt ctgaatatat tcgggtaacc gaagatgaga acgatgagcc cattgaaata    180

ccatcggaag acgatgggac ggtgctgctc tccacggtta cagcccagtt tccaggggcg    240

tgtgggcttc gctacaggaa tccagtgtct cagtgtatga gaggtgtccg gctggtagaa    300

ggaattctgc atgccccaga tgctggctgg ggaaatctgg tgtatgttgt caactatcca    360

aaagataaca aaagaaaaat ggatgagaca gatgcttcat cagcagtgaa agtgaaaaga    420

gcagtccaga aaacatccga tttaatagtg ttgggtctcc catggaaaac aaccgaacag    480

gacctgaaag agtattttag tacctttgga gaagttctta tggtgcaggt caagaaagat    540

cttaagactg gtcattcaaa ggggtttggc tttgttcgtt ttacggaata tgaaacacaa    600

gtgaaagtaa tgtcacagcg acatatgata gatggacgat ggtgtgactg caaacttcct    660

aattctaagc aaagccaaga tgagcctttg agaagcagaa aagtgtttgt ggggcgctgt    720

acagaggaca tgactgagga tgagctgcgg gagttcttct ctcagtacgg ggatgtgatg    780

gatgtcttca tccccaagcc attcagggcc tttgcctttg ttacatttgc agatgatcag    840

attgcgcagt ctctttgtgg agaggacttg atcattaaag gaatcagcgt tcatatatcc    900

aatgccgaac ctaagcacaa tagcaataga cagttagaaa gaagtggaag atttggtggt    960

aatccaggtg gctttgggaa tcagggtgga tttggtaata gcagaggggg tggagctggt   1020

ttgggaaaca atcaaggtag taatatgggt ggtgggatga actttggtgc gttcagcatt   1080

aatccagcca tgatggctgc cgcccaggca gcactacaga gcagttgggg tatgatgggc   1140

atgttagcca gccagcagaa ccagtcaggc ccatcgggta ataaccaaaa ccaaggcaac   1200

atgcagaggg agccaaacca ggccttcggt tctggaaata actcttatag tggctctaat   1260

tctggtgcag caattggttg gggatcagca tccaatgcag ggtcgggcag tggttttaat   1320

ggaggctttg gctcaagcat ggattctaag tcttctggct ggggaatgta gacagtgggg   1380

ttgtggttgg ttggtataga atggtgggaa ttcaaatttt tctaaactca tggtaagtat   1440

attgtaaaat acatatgtac taagaatttt caaaattggt ttgttcagtg tggagtatat   1500

tcagcagtat ttttgacatt tttctttaga aaaaggaaga gctaaaggaa ttttataagt   1560

tttgttacat gaaaggttga aatattgagt ggttgaaagt gaactgctgt ttgcctgatt   1620

ggtaaaccaa cacactacaa ttgatatcaa aaggtttctc ctgtaatatt ttatccctgg   1680

acttgtcaag tgaattcttt gcatgttcaa aacggaaacc attgattaga actacattct   1740

ttaccccttg ttttaatttg aaccccacca tatggatttt tttccttaag aaaatctcct   1800

tttaggagat catggtgtca cagtgtttgg ttcttttgtt ttgtttttta acacttgtct   1860

cccctcatac acaaaagtac aatatgaagc cttcatttaa tctctgcagt tcatctcatt   1920

tcaaatgttt atggaagaag cacttcattg aaagtagtgc tgtaaatatt ctgccatagg   1980

aatactgtct acatgctttc tcattcaaga attcgtcatc acgcatcaca ggccgcgtct   2040

ttgacggtgg gtgtcccatt tttatccgct actctttatt tcatggagtc gtatcaacgc   2100

tatgaacgca aggctgtgat atggaaccag aaggctgtct gaacttttga aaccttgtgt   2160

gggattgatg gtggtgccga ggcatgaaag gctagtatga gcgagaaaag gagagagcgc   2220

gtgcagagac ttggtggtgc ataatggata ttttttaact tggcgagatg tgtctctcaa   2280

tcctgtggct ttggtgagag agtgtgcaga gagcaatgat agcaaataat gtacgaatgt   2340

tttttgcatt caaaggacat ccacatctgt tggaagactt ttaagtgagt ttttgttctt   2400

agataaccca cattagatga atgtgttaag tgaaatgata cttgtactcc ccctacccct   2460

ttgtcaactg ctgtgaatgc tgtatggtgt gtgttctctt ctgttactga tatgtaagtg   2520

tggcaatgtg aactgaagct gatgggctga gaacatggac tgagcttgtg gtgtgctttg   2580

caggaggact tgaagcagag ttcaccagtg agctcaggtg tctcaaagaa gggtggaagt   2640

tctaatgtct gttagctacc cataagaatg ctgtttgctg cagttctgtg tcctgtgctt   2700

ggatgctttt tataagagtt gtcattgttg gaaattctta aataaaactg atttaaataa   2760

tatgtgtctt tgttttgcag ccctgaatgc aaagaattca tagcagttaa ttcccctttt   2820

ttgacccttt tgagatggaa ctttcataaa gtttcttggc agtagtttat tttgcttcaa   2880

ataaacttat ttgaaaagtt g                                             2901


<210>  1378
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  1378

Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
1               5                   10                  15


Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            20                  25                  30


Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        35                  40                  45


Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    50                  55                  60


Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Asp 
65                  70                  75                  80


Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser Ala Val Lys Val 
                85                  90                  95


Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val Leu Gly Leu Pro 
            100                 105                 110


Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly 
        115                 120                 125


Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys Thr Gly His Ser 
    130                 135                 140


Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu Thr Gln Val Lys 
145                 150                 155                 160


Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp Cys Asp Cys Lys 
                165                 170                 175


Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu Arg Ser Arg Lys 
            180                 185                 190


Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp Glu Leu Arg 
        195                 200                 205


Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe Ile Pro Lys 
    210                 215                 220


Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp Gln Ile Ala 
225                 230                 235                 240


Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile Ser Val His 
                245                 250                 255


Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln Leu Glu Arg 
            260                 265                 270


Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly 
        275                 280                 285


Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly 
    290                 295                 300


Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro 
305                 310                 315                 320


Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met 
                325                 330                 335


Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn 
            340                 345                 350


Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly 
        355                 360                 365


Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly 
    370                 375                 380


Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly 
385                 390                 395                 400


Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
                405                 410


<210>  1379
<211>  4305
<212>  DNA
<213>  Homo sapiens

<400>  1379
gggggaggag gcggccctag cgccattttg tgggagcgaa gcggtggctg ggctgcgctt     60

gggtccgtcg ctgcttcggt gtccctgtcg ggcttcccag cagcggccta gcgggaaaag    120

taaaagatgt ctgaatatat tcgggtaacc gaagatgaga acgatgagcc cattgaaata    180

ccatcggaag acgatgggac ggtgctgctc tccacggtta cagcccagtt tccaggggcg    240

tgtgggcttc gctacaggaa tccagtgtct cagtgtatga gaggtgtccg gctggtagaa    300

ggaattctgc atgccccaga tgctggctgg ggaaatctgg tgtatgttgt caactatcca    360

aaagataaca aaagaaaaat ggatgagaca gatgcttcat cagcagtgaa agtgaaaaga    420

gcagtccaga aaacatccga tttaatagtg ttgggtctcc catggaaaac aaccgaacag    480

gacctgaaag agtattttag tacctttgga gaagttctta tggtgcaggt caagaaagat    540

cttaagactg gtcattcaaa ggggtttggc tttgttcgtt ttacggaata tgaaacacaa    600

gtgaaagtaa tgtcacagcg acatatgata gatggacgat ggtgtgactg caaacttcct    660

aattctaagc aaagccaaga tgagcctttg agaagcagaa aagtgtttgt ggggcgctgt    720

acagaggaca tgactgagga tgagctgcgg gagttcttct ctcagtacgg ggatgtgatg    780

gatgtcttca tccccaagcc attcagggcc tttgcctttg ttacatttgc agatgatcag    840

attgcgcagt ctctttgtgg agaggacttg atcattaaag gaatcagcgt tcatatatcc    900

aatgccgaac ctaagcacaa tagcaataga cagttagaaa gaagtggaag atttggtggt    960

aatccaggtg gctttgggaa tcagggtgga tttggtaata gcagaggggg tggagctggt   1020

ttgggaaaca atcaaggtag taatatgggt ggtgggatga actttggtgc gttcagcatt   1080

aatccagcca tgatggctgc cgcccaggca gcactacaga gcagttgggg tatgatgggc   1140

atgttagcca gccagcagaa ccagtcaggc ccatcgggta ataaccaaaa ccaaggcaac   1200

atgcagaggg agccaaacca ggccttcggt tctggaaata actcttatag tggctctaat   1260

tctggtgcag caattggttg gggatcagca tccaatgcag ggtcgggcag tggttttaat   1320

ggaggctttg gctcaagcat ggattctaag tcttctggct ggggaatgta gacagtgggg   1380

ttgtggttgg ttggtataga atggtgggaa ttcaaatttt tctaaactca tggtaagtat   1440

attgtaaaat acatatgtac taagaatttt caaaattggt ttgttcagtg tggagtatat   1500

tcagcagtat ttttgacatt tttctttaga aaaaggaaga gctaaaggaa ttttataagt   1560

tttgttacat gaaaggttga aatattgagt ggttgaaagt gaactgctgt ttgcctgatt   1620

ggtaaaccaa cacactacaa ttgatatcaa aaggtttctc ctgtaatatt ttatccctgg   1680

acttgtcaag tgaattcttt gcatgttcaa aacggaaacc attgattaga actacattct   1740

ttaccccttg ttttaatttg aaccccacca tatggatttt tttccttaag aaaatctcct   1800

tttaggagat catggtgtca cagtgtttgg ttcttttgtt ttgtttttta acacttgtct   1860

cccctcatac acaaaagtac aatatgaagc cttcatttaa tctctgcagt tcatctcatt   1920

tcaaatgttt atggaagaag cacttcattg aaagtagtgc tgtaaatatt ctgccatagg   1980

aatactgtct acatgctttc tcattcaaga attcgtcatc acgcatcaca ggccgcgtct   2040

ttgacggtgg gtgtcccatt tttatccgct actctttatt tcatggagtc gtatcaacgc   2100

tatgaacgca aggctgtgat atggaaccag aaggctgtct gaacttttga aaccttgtgt   2160

gggattgatg gtggtgccga ggcatgaaag gctagtatga gcgagaaaag gagagagcgc   2220

gtgcagagac ttggtggtgc ataatggata ttttttaact tggcgagatg tgtctctcaa   2280

tcctgtggct ttggtgagag agtgtgcaga gagcaatgat agcaaataat gtacgaatgt   2340

tttttgcatt caaaggacat ccacatctgt tggaagactt ttaagtgagt ttttgttctt   2400

agataaccca cattagatga atgtgttaag tgaaatgata cttgtactcc ccctacccct   2460

ttgtcaactg ctgtgaatgc tgtatggtgt gtgttctctt ctgttactga tatgtaagtg   2520

tggcaatgtg aactgaagct gatgggctga gaacatggac tgagcttgtg gtgtgctttg   2580

caggaggact tgaagcagag ttcaccagtg agctcaggtg tctcaaagaa gggtggaagt   2640

tctaatgtct gttagctacc cataagaatg ctgtttgctg cagttctgtg tcctgtgctt   2700

ggatgctttt tataagagtt gtcattgttg gaaattctta aataaaactg atttaaataa   2760

tatgtgtctt tgttttgcag ccctgaatgc aaagaattca tagcagttaa ttcccctttt   2820

ttgacccttt tgagatggaa ctttcataaa gtttcttggc agtagtttat tttgcttcaa   2880

ataaacttat ttgaaaagtt gtctcaagtc aaatggattc atcacctgtc atgcattgac   2940

acctgatacc cagacttaat tggtatttgt tcttgcattg gccaaagtga aaattttttt   3000

ttttcttttg aaatctagtt ttgaataagt ctgggtgacc gcacctaaaa tggtaagcag   3060

taccctccgg ctttttctta gtgcctctgt gcatttgggt gatgttctat ttacatggcc   3120

tgtgtaaatc tccattggga agtcatgcct tctaaaaaga ttcttatttg ggggagtggg   3180

caaaatgttg attattttct aatgctttgt agcaaagcat atcaattgaa aagggaatat   3240

cagcaccttc ctagtttggg atttgaaaag tggaattaat tgcagtaggg ataaagtaga   3300

agaaaccaca aattatcttg tgcctgaaat ccattaagag gcctgatagc tttaagaatt   3360

agggtgggtt gtctgtctgg aagtgttaag tggaatgggc tttgtcctcc aggaggtggg   3420

ggaatgtggt aacattgaat acagttgaat aaaatcgctt acaaaactca cactctcaca   3480

atgcattgtt aagtatgtaa aagcaataac attgattctc tgttgtactt ttttgtaact   3540

aattctgtga gagttgagct cattttctag ttggaagaat gtgatatttg ttgtgttggt   3600

agtttaccta atgcccttac ctaattagat tatgataaat aggtttgtca ttttgcaagt   3660

tacataaaca tttatcaatg aagtcatcct ttagacttgt aatcgccaca ttgtttcatt   3720

attcagtttc ctctgtaaag ggatcttgag ttgttttaat tttttttttc tgcatctgaa   3780

tctgcatgat ttccaaaccc tgtaccatct gaattttgca ttttagcact tgcactatta   3840

ctcagcagca gtaacatggt aacacttaaa atggtactcg gggacctcca aagactaaac   3900

tgacaagcct tcaaggagcc caggggtaag ttaacttgtc aacggcatgg tttaatccct   3960

tctttacact tgtgtaaatt tcagttactg gtcatagaag gctttcaatg ttgagtggcc   4020

ttttattaac atgtttatgg tactgcatag atacgggtat ttattttacc ctaagaagat   4080

tttgaagttt aaaagtactt aaactatttg gcaaagattt gtttttaaaa atctatttgg   4140

tcaatctaaa tgcattcatt ctaaaaaatt ttttgaacca gataaataaa attttttttt   4200

gacaccacag tttagtgtct ggagtcttac tggaaaaaca cgatttcttt ttatatgtga   4260

tatacagatg ctggaaagtt acctttaaaa attgagtctc taaag                   4305


<210>  1380
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  1380

Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
1               5                   10                  15


Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            20                  25                  30


Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        35                  40                  45


Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    50                  55                  60


Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Asp 
65                  70                  75                  80


Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser Ala Val Lys Val 
                85                  90                  95


Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val Leu Gly Leu Pro 
            100                 105                 110


Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly 
        115                 120                 125


Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys Thr Gly His Ser 
    130                 135                 140


Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu Thr Gln Val Lys 
145                 150                 155                 160


Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp Cys Asp Cys Lys 
                165                 170                 175


Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu Arg Ser Arg Lys 
            180                 185                 190


Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp Glu Leu Arg 
        195                 200                 205


Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe Ile Pro Lys 
    210                 215                 220


Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp Gln Ile Ala 
225                 230                 235                 240


Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile Ser Val His 
                245                 250                 255


Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln Leu Glu Arg 
            260                 265                 270


Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly 
        275                 280                 285


Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly 
    290                 295                 300


Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro 
305                 310                 315                 320


Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met 
                325                 330                 335


Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn 
            340                 345                 350


Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly 
        355                 360                 365


Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly 
    370                 375                 380


Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly 
385                 390                 395                 400


Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
                405                 410


<210>  1381
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  1381
cattttgtgg gagcgaagcg gtggctgggc tgcgcttggg tccgtcgctg cttcggtgtc     60

cctgtcgggc ttcccagcag cggcctagcg ggaaaagtaa aagatgtctg aatatattcg    120

ggtaaccgaa gatgagaacg atgagcccat tgaaatacca tcggaagacg atgggacggt    180

gctgctctcc acggttacag cccagtttcc aggggcgtgt gggcttcgct acaggaatcc    240

agtgtctcag tgtatgagag gtgtccggct ggtagaagga attctgcatg ccccagatgc    300

tggctgggga aatctggtgt atgttgtcaa ctatcc                              336


<210>  1382
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  1382

Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
1               5                   10                  15


Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            20                  25                  30


Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        35                  40                  45


Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    50                  55                  60


Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn 
65                  70                  75


<210>  1383
<211>  539
<212>  DNA
<213>  Homo sapiens

<400>  1383
cattttgtgg gagcgaagcg gtggctgggc tgcgcttggg tccgtcgctg cttcggtgtc     60

cctgtcgggc ttcccagcag cggcctagcg ggaaaagtaa aagatgtctg aatatattcg    120

ggtaaccgaa gatgagaacg atgagcccat tgaaatacca tcggaagacg atgggacggt    180

gctgctctcc acggttacag cccagtttcc aggggcgtgt gggcttcgct acaggaatcc    240

agtgtctcag tgtatgagag gtgtccggct ggtagaagga attctgcatg ccccagatgc    300

tggctgggga aatctggtgt atgttgtcaa ctatccaaaa ggctggacat ggtggctcac    360

atctgtaatc ccagctactc gggaggctga ggcaggagaa tcacttgaac ccgggaggca    420

gaggttgcag agaggggaga ttgcgccact gcactccagc ctagataaca aaagaaaaat    480

ggatgagaca gatgcttcat cagcagtgaa agtgaaaaga gcagtccaga aaacatccg     539


<210>  1384
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  1384

Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
1               5                   10                  15


Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            20                  25                  30


Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        35                  40                  45


Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    50                  55                  60


Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Gly 
65                  70                  75                  80


Trp Thr Trp Trp Leu Thr Ser Val Ile Pro Ala Thr Arg Glu Ala Glu 
                85                  90                  95


Ala Gly Glu Ser Leu Glu Pro Gly Arg Gln Arg Leu Gln Arg Gly Glu 
            100                 105                 110


Ile Ala Pro Leu His Ser Ser Leu Asp Asn Lys Arg Lys Met Asp Glu 
        115                 120                 125


Thr Asp Ala Ser Ser Ala Val Lys Val Lys Arg Ala Val Gln Lys Thr 
    130                 135                 140


<210>  1385
<211>  564
<212>  DNA
<213>  Homo sapiens

<400>  1385
cattttgtgg gagcgaagcg gtggctgggc tgcgcttggg tccgtcgctg cttcggtgtc     60

cctgtcgggc ttcccagcag cggcctagcg ggaaaagtaa aagatgtctg aatatattcg    120

ggtaaccgaa gatgagaacg atgagcccat tgaaatacca tcggaagacg atgggacggt    180

gctgctctcc acggttacag cccagtttcc aggggcgtgt gggcttcgct acaggaatcc    240

agtgtctcag tgtatgagag gtgtccggct ggtagaagga attctgcatg ccccagatgc    300

tggctgggga aatctggtgt atgttgtcaa ctatccaaaa gtatagacgg cgtttcacca    360

tcttggccag gctggtcttg aactcctgac cttgtgatcc acctgcctca gactcccaaa    420

gtgctgggat tacaagtgtg agccaccgcg cccagccagt tatgtttttt taaataacaa    480

aagaaaaatg gatgagacag atgcttcatc agcagtgaaa gtgaaaagag cagtccagaa    540

aacatccgat ttaatagtgt tggg                                           564


<210>  1386
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  1386

Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
1               5                   10                  15


Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            20                  25                  30


Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        35                  40                  45


Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    50                  55                  60


Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Val 
65                  70                  75                  80


<210>  1387
<211>  3017
<212>  DNA
<213>  Homo sapiens

<400>  1387
cattttgtgg gagcgaagcg gtggctgggc tgcgcttggg tccgtcgctg cttcggtgtc     60

cctgtcgggc ttcccagcag cggcctagcg ggaaaagtaa aagatgtctg aatatattcg    120

ggtaaccgaa gatgagaacg atgagcccat tgaaatacca tcggaagacg atgggacggt    180

gctgctctcc acggttacag cccagtttcc aggggcgtgt gggcttcgct acaggaatcc    240

agtgtctcag tgtatgagag gtgtccggct ggtagaagga attctgcatg ccccagatgc    300

tggctgggga aatctggtgt atgttgtcaa ctatccaaaa gtatagacgg cgtttcacca    360

tcttggccag gctggtcttg aactcctgac cttgtgatcc accacgcctg gccagttttt    420

tgtatcttta gtagataacg gggtttcact gttttgatct ggctggtctt gaactcctga    480

cctcaggtga tccacccccc tcagcctccc aaagtgctgg gattacaggc gtgagccact    540

gctcctgctc ccggcccatt ttttaaatta ttattttgag acagggtctc actctgttgc    600

ccaggctggt ggaacacagt ggtgtaatca tagctcacta caccctagaa ctcctgggct    660

cagcctccag ggggaggatc ctccagcttc agcctcccaa gtagctagga cagatgcatg    720

ccactacgcc cagctaatgt ggcttttttg tggttttttt tgatagaggt ggggtctccc    780

tgtgttgtct aggctgccag gctagtcttg aactattggc ctcacacagt cctcccacct    840

tggcctccca aagcgctagg attacaggca tgagccacca tgcccagcct atgtcttttg    900

aaaatcgact gaaatatcac tgctgctgtt aataaaacta aaagctgtat tgggggttta    960

aatgaaatga gtgttcattg cttatttttc ctctggcttt agataaatta atgcttgtaa   1020

tctaagtttt gttgctactt taaatatatg aatcagtggt ttaatcttct ttgtttacat   1080

cccttatttc ttatagattg cgcagtctct ttgtggagag gacttgatca ttaaaggaat   1140

cagcgttcat atatccaatg ccgaacctaa gcacaatagc aatagacagt tagaaagaag   1200

tggaagattt ggtggtaatc caggtggctt tgggaatcag ggtggatttg gtaatagcag   1260

agggggtgga gctggtttgg gaaacaatca aggtagtaat atgggtggtg ggatgaactt   1320

tggtgcgttc agcattaatc cagccatgat ggctgccgcc caggcagcac tacagagcag   1380

ttggggtatg atgggcatgt tagccagcca gcagaaccag tcaggcccat cgggtaataa   1440

ccaaaaccaa ggcaacatgc agagggagcc aaaccaggcc ttcggttctg gaaataactc   1500

ttatagtggc tctaattctg gtgcagcaat tggttgggga tcagcatcca atgcagggtc   1560

gggcagtggt tttaatggag gctttggctc aagcatggat tctaagtctt ctggctgggg   1620

aatgtagaca gtggggttgt ggttggttgg tatagaatgg tgggaattca aatttttcta   1680

aactcatggt aagtatattg taaaatacat atgtactaag aattttcaaa attggtttgt   1740

tcagtgtgga gtatattcag cagtattttt gacatttttc tttagaaaaa ggaagagcta   1800

aaggaatttt ataagttttg ttacatgaaa ggttgaaata ttgagtggtt gaaagtgaac   1860

tgctgtttgc ctgattggta aaccaacaca ctacaattga tatcaaaagg tttctcctgt   1920

aatattttat ccctggactt gtcaagtgaa ttctttgcat gttcaaaacg gaaaccattg   1980

attagaacta cattctttac cccttgtttt aatttgaacc ccaccatatg gatttttttc   2040

cttaagaaaa tctcctttta ggagatcatg gtgtcacagt gtttggttct tttgttttgt   2100

tttttaacac ttgtctcccc tcatacacaa aagtacaata tgaagccttc atttaatctc   2160

tgcagttcat ctcatttcaa atgtttatgg aagaagcact tcattgaaag tagtgctgta   2220

aatattctgc cataggaata ctgtctacat gctttctcat tcaagaattc gtcatcacgc   2280

atcacaggcc gcgtctttga cggtgggtgt cccattttta tccgctactc tttatttcat   2340

ggagtcgtat caacgctatg aacgcaaggc tgtgatatgg aaccagaagg ctgtctgaac   2400

ttttgaaacc ttgtgtggga ttgatggtgg tgccgaggca tgaaaggcta gtatgagcga   2460

gaaaaggaga gagcgcgtgc agagacttgg tggtgcataa tggatatttt ttaacttggc   2520

gagatgtgtc tctcaatcct gtggctttgg tgagagagtg tgcagagagc aatgatagca   2580

aataatgtac gaatgttttt tgcattcaaa ggacatccac atctgttgga agacttttaa   2640

gtgagttttt gttcttagat aacccacatt agatgaatgt gttaagtgaa atgatacttg   2700

tactccccct acccctttgt caactgctgt gaatgctgta tggtgtgtgt tctcttctgt   2760

tactgatatg taagtgtggc aatgtgaact gaagctgatg ggctgagaac atggactgag   2820

cttgtggtgt gctttgcagg aggacttgaa gcagagttca ccagtgagct caggtgtctc   2880

aaagaagggt ggaagttcta atgtctgtta gctacccata agaatgctgt ttgctgcagt   2940

tctgtgtcct gtgcttggat gctttttata agagttgtca ttgttggaaa ttcttaaata   3000

aaactgattt aaataat                                                  3017


<210>  1388
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  1388

Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
1               5                   10                  15


Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            20                  25                  30


Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        35                  40                  45


Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    50                  55                  60


Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Val 
65                  70                  75                  80


<210>  1389
<211>  3157
<212>  DNA
<213>  Homo sapiens

<400>  1389
cattttgtgg gagcgaagcg gtggctgggc tgcgcttggg tccgtcgctg cttcggtgtc     60

cctgtcgggc ttcccagcag cggcctagcg ggaaaagtaa aagatgtctg aatatattcg    120

ggtaaccgaa gatgagaacg atgagcccat tgaaatacca tcggaagacg atgggacggt    180

gctgctctcc acggttacag cccagtttcc aggggcgtgt gggcttcgct acaggaatcc    240

agtgtctcag tgtatgagag gtgtccggct ggtagaagga attctgcatg ccccagatgc    300

tggctgggga aatctggtgt atgttgtcaa ctatccaaaa gtatagacgg cgtttcacca    360

tcttggccag gctggtcttg aactcctgac cttgtgatcc accacgcctg gccagttttt    420

tgtatcttta gtagataacg gggtttcact gttttgatct ggctggtctt gaactcctga    480

cctcaggtga tccacccccc tcagcctccc aaagtgctgg gattacaggc gtgagccact    540

gctcctgctc ccggcccatt ttttaaatta ttattttgag acagggtctc actctgttgc    600

ccaggctggt ggaacacagt ggtgtaatca tagctcacta caccctagaa ctcctgggct    660

cagcctccag ggggaggatc ctccagcttc agcctcccaa gtagctagga cagatgcatg    720

ccactacgcc cagctaatgt ggcttttttg tggttttttt tgatagaggt ggggtctccc    780

tgtgttgtct aggctgccag gctagtcttg aactattggc ctcacacagt cctcccacct    840

tggcctccca aagcgctagg attacaggca tgagccacca tgcccagcct atgtcttttg    900

aaaatcgact gaaatatcac tgctgctgtt aataaaacta aaagctgtat tgggggttta    960

aatgaaatga gtgttcattg cttatttttc ctctggcttt agataaatta atgcttgtaa   1020

tctaagtttt gttgctactt taaatatatg aatcagtggt ttaatcttct ttgtttacat   1080

cccttatttc ttatagattg cgcagtctct ttgtggagag gacttgatca ttaaaggaat   1140

cagcgttcat atatccaatg ccgaacctaa gcacaatagc aatagacagt tagaaagaag   1200

tggaagattt ggtggtaatc caggtggctt tgggaatcag ggtggatttg gtaatagcag   1260

agggggtgga gctggtttgg gaaacaatca aggtagtaat atgggtggtg ggatgaactt   1320

tggtgcgttc agcattaatc cagccatgat ggctgccgcc caggcagcac tacagagcag   1380

ttggggtatg atgggcatgt tagccagcca gcagaaccag tcaggcccat cgggtaataa   1440

ccaaaaccaa ggcaacatgc agagggagcc aaaccaggcc ttcggttctg gaaataactc   1500

ttatagtggc tctaattctg gtgcagcaat tggttgggga tcagcatcca atgcagggtc   1560

gggcagtggt tttaatggag gctttggctc aagcatggat tctaagtctt ctggctgggg   1620

aatgtagaca gtggggttgt ggttggttgg tatagaatgg tgggaattca aatttttcta   1680

aactcatggt aagtatattg taaaatacat atgtactaag aattttcaaa attggtttgt   1740

tcagtgtgga gtatattcag cagtattttt gacatttttc tttagaaaaa ggaagagcta   1800

aaggaatttt ataagttttg ttacatgaaa ggttgaaata ttgagtggtt gaaagtgaac   1860

tgctgtttgc ctgattggta aaccaacaca ctacaattga tatcaaaagg tttctcctgt   1920

aatattttat ccctggactt gtcaagtgaa ttctttgcat gttcaaaacg gaaaccattg   1980

attagaacta cattctttac cccttgtttt aatttgaacc ccaccatatg gatttttttc   2040

cttaagaaaa tctcctttta ggagatcatg gtgtcacagt gtttggttct tttgttttgt   2100

tttttaacac ttgtctcccc tcatacacaa aagtacaata tgaagccttc atttaatctc   2160

tgcagttcat ctcatttcaa atgtttatgg aagaagcact tcattgaaag tagtgctgta   2220

aatattctgc cataggaata ctgtctacat gctttctcat tcaagaattc gtcatcacgc   2280

atcacaggcc gcgtctttga cggtgggtgt cccattttta tccgctactc tttatttcat   2340

ggagtcgtat caacgctatg aacgcaaggc tgtgatatgg aaccagaagg ctgtctgaac   2400

ttttgaaacc ttgtgtggga ttgatggtgg tgccgaggca tgaaaggcta gtatgagcga   2460

gaaaaggaga gagcgcgtgc agagacttgg tggtgcataa tggatatttt ttaacttggc   2520

gagatgtgtc tctcaatcct gtggctttgg tgagagagtg tgcagagagc aatgatagca   2580

aataatgtac gaatgttttt tgcattcaaa ggacatccac atctgttgga agacttttaa   2640

gtgagttttt gttcttagat aacccacatt agatgaatgt gttaagtgaa atgatacttg   2700

tactccccct acccctttgt caactgctgt gaatgctgta tggtgtgtgt tctcttctgt   2760

tactgatatg taagtgtggc aatgtgaact gaagctgatg ggctgagaac atggactgag   2820

cttgtggtgt gctttgcagg aggacttgaa gcagagttca ccagtgagct caggtgtctc   2880

aaagaagggt ggaagttcta atgtctgtta gctacccata agaatgctgt ttgctgcagt   2940

tctgtgtcct gtgcttggat gctttttata agagttgtca ttgttggaaa ttcttaaata   3000

aaactgattt aaataatatg tgtctttgtt ttgcagccct gaatgcaaag aattcatagc   3060

agttaattcc ccttttttga cccttttgag atggaacttt cataaagttt cttggcagta   3120

gtttattttg cttcaaataa acttatttga aaagttg                            3157


<210>  1390
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  1390

Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
1               5                   10                  15


Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            20                  25                  30


Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        35                  40                  45


Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    50                  55                  60


Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Val 
65                  70                  75                  80


<210>  1391
<211>  4464
<212>  DNA
<213>  Homo sapiens

<400>  1391
cattttgtgg gagcgaagcg gtggctgggc tgcgcttggg tccgtcgctg cttcggtgtc     60

cctgtcgggc ttcccagcag cggcctagcg ggaaaagtaa aagatgtctg aatatattcg    120

ggtaaccgaa gatgagaacg atgagcccat tgaaatacca tcggaagacg atgggacggt    180

gctgctctcc acggttacag cccagtttcc aggggcgtgt gggcttcgct acaggaatcc    240

agtgtctcag tgtatgagag gtgtccggct ggtagaagga attctgcatg ccccagatgc    300

tggctgggga aatctggtgt atgttgtcaa ctatccaaaa gtatagacgg cgtttcacca    360

tcttggccag gctggtcttg aactcctgac cttgtgatcc accacgcctg gccagttttt    420

tgtatcttta gtagataacg gggtttcact gttttgatct ggctggtctt gaactcctga    480

cctcaggtga tccacccccc tcagcctccc aaagtgctgg gattacaggc gtgagccact    540

gctcctgctc ccggcccatt ttttaaatta ttattttgag acagggtctc actctgttgc    600

ccaggctggt ggaacacagt ggtgtaatca tagctcacta caccctagaa ctcctgggct    660

cagcctccag ggggaggatc ctccagcttc agcctcccaa gtagctagga cagatgcatg    720

ccactacgcc cagctaatgt ggcttttttg tggttttttt tgatagaggt ggggtctccc    780

tgtgttgtct aggctgccag gctagtcttg aactattggc ctcacacagt cctcccacct    840

tggcctccca aagcgctagg attacaggca tgagccacca tgcccagcct atgtcttttg    900

aaaatcgact gaaatatcac tgctgctgtt aataaaacta aaagctgtat tgggggttta    960

aatgaaatga gtgttcattg cttatttttc ctctggcttt agataaatta atgcttgtaa   1020

tctaagtttt gttgctactt taaatatatg aatcagtggt ttaatcttct ttgtttacat   1080

cccttatttc ttatagattg cgcagtctct ttgtggagag gacttgatca ttaaaggaat   1140

cagcgttcat atatccaatg ccgaacctaa gcacaatagc aatagacagt tagaaagaag   1200

tggaagattt ggtggtaatc caggtggctt tgggaatcag ggtggatttg gtaatagcag   1260

agggggtgga gctggtttgg gaaacaatca aggtagtaat atgggtggtg ggatgaactt   1320

tggtgcgttc agcattaatc cagccatgat ggctgccgcc caggcagcac tacagagcag   1380

ttggggtatg atgggcatgt tagccagcca gcagaaccag tcaggcccat cgggtaataa   1440

ccaaaaccaa ggcaacatgc agagggagcc aaaccaggcc ttcggttctg gaaataactc   1500

ttatagtggc tctaattctg gtgcagcaat tggttgggga tcagcatcca atgcagggtc   1560

gggcagtggt tttaatggag gctttggctc aagcatggat tctaagtctt ctggctgggg   1620

aatgtagaca gtggggttgt ggttggttgg tatagaatgg tgggaattca aatttttcta   1680

aactcatggt aagtatattg taaaatacat atgtactaag aattttcaaa attggtttgt   1740

tcagtgtgga gtatattcag cagtattttt gacatttttc tttagaaaaa ggaagagcta   1800

aaggaatttt ataagttttg ttacatgaaa ggttgaaata ttgagtggtt gaaagtgaac   1860

tgctgtttgc ctgattggta aaccaacaca ctacaattga tatcaaaagg tttctcctgt   1920

aatattttat ccctggactt gtcaagtgaa ttctttgcat gttcaaaacg gaaaccattg   1980

attagaacta cattctttac cccttgtttt aatttgaacc ccaccatatg gatttttttc   2040

cttaagaaaa tctcctttta ggagatcatg gtgtcacagt gtttggttct tttgttttgt   2100

tttttaacac ttgtctcccc tcatacacaa aagtacaata tgaagccttc atttaatctc   2160

tgcagttcat ctcatttcaa atgtttatgg aagaagcact tcattgaaag tagtgctgta   2220

aatattctgc cataggaata ctgtctacat gctttctcat tcaagaattc gtcatcacgc   2280

atcacaggcc gcgtctttga cggtgggtgt cccattttta tccgctactc tttatttcat   2340

ggagtcgtat caacgctatg aacgcaaggc tgtgatatgg aaccagaagg ctgtctgaac   2400

ttttgaaacc ttgtgtggga ttgatggtgg tgccgaggca tgaaaggcta gtatgagcga   2460

gaaaaggaga gagcgcgtgc agagacttgg tggtgcataa tggatatttt ttaacttggc   2520

gagatgtgtc tctcaatcct gtggctttgg tgagagagtg tgcagagagc aatgatagca   2580

aataatgtac gaatgttttt tgcattcaaa ggacatccac atctgttgga agacttttaa   2640

gtgagttttt gttcttagat aacccacatt agatgaatgt gttaagtgaa atgatacttg   2700

tactccccct acccctttgt caactgctgt gaatgctgta tggtgtgtgt tctcttctgt   2760

tactgatatg taagtgtggc aatgtgaact gaagctgatg ggctgagaac atggactgag   2820

cttgtggtgt gctttgcagg aggacttgaa gcagagttca ccagtgagct caggtgtctc   2880

aaagaagggt ggaagttcta atgtctgtta gctacccata agaatgctgt ttgctgcagt   2940

tctgtgtcct gtgcttggat gctttttata agagttgtca ttgttggaaa ttcttaaata   3000

aaactgattt aaataatatg tgtctttgtt ttgcagccct gaatgcaaag aattcatagc   3060

agttaattcc ccttttttga cccttttgag atggaacttt cataaagttt cttggcagta   3120

gtttattttg cttcaaataa acttatttga aaagttgtct caagtcaaat ggattcatca   3180

cctgtcatgc attgacacct gatacccaga cttaattggt atttgttctt gcattggcca   3240

aagtgaaaat tttttttttt cttttgaaat ctagttttga ataagtctgg gtgaccgcac   3300

ctaaaatggt aagcagtacc ctccggcttt ttcttagtgc ctctgtgcat ttgggtgatg   3360

ttctatttac atggcctgtg taaatctcca ttgggaagtc atgccttcta aaaagattct   3420

tatttggggg agtgggcaaa atgttgatta ttttctaatg ctttgtagca aagcatatca   3480

attgaaaagg gaatatcagc accttcctag tttgggattt gaaaagtgga attaattgca   3540

gtagggataa agtagaagaa accacaaatt atcttgtgcc tgaaatccat taagaggcct   3600

gatagcttta agaattaggg tgggttgtct gtctggaagt gttaagtgga atgggctttg   3660

tcctccagga ggtgggggaa tgtggtaaca ttgaatacag ttgaataaaa tcgcttacaa   3720

aactcacact ctcacaatgc attgttaagt atgtaaaagc aataacattg attctctgtt   3780

gtactttttt gtaactaatt ctgtgagagt tgagctcatt ttctagttgg aagaatgtga   3840

tatttgttgt gttggtagtt tacctaatgc ccttacctaa ttagattatg ataaataggt   3900

ttgtcatttt gcaagttaca taaacattta tcaatgaagt catcctttag acttgtaatc   3960

gccacattgt ttcattattc agtttcctct gtaaagggat cttgagttgt tttaattttt   4020

tttttctgca tctgaatctg catgatttcc aaaccctgta ccatctgaat tttgcatttt   4080

agcacttgca ctattactca gcagcagtaa catggtaaca cttaaaatgg tactcgggga   4140

cctccaaaga ctaaactgac aagccttcaa ggagcccagg ggtaagttaa cttgtcaacg   4200

gcatggttta atcccttctt tacacttgtg taaatttcag ttactggtca tagaaggctt   4260

tcaatgttga gtggcctttt attaacatgt ttatggtact gcatagatac gggtatttat   4320

tttaccctaa gaagattttg aagtttaaaa gtacttaaac tatttggcaa agatttgttt   4380

ttaaaaatct atttggtcaa tctaaatgca ttcattctaa aaaatttttt gaaccagata   4440

aataaaattt ttttttgaca ccac                                          4464


<210>  1392
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  1392

Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
1               5                   10                  15


Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            20                  25                  30


Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        35                  40                  45


Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    50                  55                  60


Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Val 
65                  70                  75                  80


<210>  1393
<211>  4561
<212>  DNA
<213>  Homo sapiens

<400>  1393
cattttgtgg gagcgaagcg gtggctgggc tgcgcttggg tccgtcgctg cttcggtgtc     60

cctgtcgggc ttcccagcag cggcctagcg ggaaaagtaa aagatgtctg aatatattcg    120

ggtaaccgaa gatgagaacg atgagcccat tgaaatacca tcggaagacg atgggacggt    180

gctgctctcc acggttacag cccagtttcc aggggcgtgt gggcttcgct acaggaatcc    240

agtgtctcag tgtatgagag gtgtccggct ggtagaagga attctgcatg ccccagatgc    300

tggctgggga aatctggtgt atgttgtcaa ctatccaaaa gtatagacgg cgtttcacca    360

tcttggccag gctggtcttg aactcctgac cttgtgatcc accacgcctg gccagttttt    420

tgtatcttta gtagataacg gggtttcact gttttgatct ggctggtctt gaactcctga    480

cctcaggtga tccacccccc tcagcctccc aaagtgctgg gattacaggc gtgagccact    540

gctcctgctc ccggcccatt ttttaaatta ttattttgag acagggtctc actctgttgc    600

ccaggctggt ggaacacagt ggtgtaatca tagctcacta caccctagaa ctcctgggct    660

cagcctccag ggggaggatc ctccagcttc agcctcccaa gtagctagga cagatgcatg    720

ccactacgcc cagctaatgt ggcttttttg tggttttttt tgatagaggt ggggtctccc    780

tgtgttgtct aggctgccag gctagtcttg aactattggc ctcacacagt cctcccacct    840

tggcctccca aagcgctagg attacaggca tgagccacca tgcccagcct atgtcttttg    900

aaaatcgact gaaatatcac tgctgctgtt aataaaacta aaagctgtat tgggggttta    960

aatgaaatga gtgttcattg cttatttttc ctctggcttt agataaatta atgcttgtaa   1020

tctaagtttt gttgctactt taaatatatg aatcagtggt ttaatcttct ttgtttacat   1080

cccttatttc ttatagattg cgcagtctct ttgtggagag gacttgatca ttaaaggaat   1140

cagcgttcat atatccaatg ccgaacctaa gcacaatagc aatagacagt tagaaagaag   1200

tggaagattt ggtggtaatc caggtggctt tgggaatcag ggtggatttg gtaatagcag   1260

agggggtgga gctggtttgg gaaacaatca aggtagtaat atgggtggtg ggatgaactt   1320

tggtgcgttc agcattaatc cagccatgat ggctgccgcc caggcagcac tacagagcag   1380

ttggggtatg atgggcatgt tagccagcca gcagaaccag tcaggcccat cgggtaataa   1440

ccaaaaccaa ggcaacatgc agagggagcc aaaccaggcc ttcggttctg gaaataactc   1500

ttatagtggc tctaattctg gtgcagcaat tggttgggga tcagcatcca atgcagggtc   1560

gggcagtggt tttaatggag gctttggctc aagcatggat tctaagtctt ctggctgggg   1620

aatgtagaca gtggggttgt ggttggttgg tatagaatgg tgggaattca aatttttcta   1680

aactcatggt aagtatattg taaaatacat atgtactaag aattttcaaa attggtttgt   1740

tcagtgtgga gtatattcag cagtattttt gacatttttc tttagaaaaa ggaagagcta   1800

aaggaatttt ataagttttg ttacatgaaa ggttgaaata ttgagtggtt gaaagtgaac   1860

tgctgtttgc ctgattggta aaccaacaca ctacaattga tatcaaaagg tttctcctgt   1920

aatattttat ccctggactt gtcaagtgaa ttctttgcat gttcaaaacg gaaaccattg   1980

attagaacta cattctttac cccttgtttt aatttgaacc ccaccatatg gatttttttc   2040

cttaagaaaa tctcctttta ggagatcatg gtgtcacagt gtttggttct tttgttttgt   2100

tttttaacac ttgtctcccc tcatacacaa aagtacaata tgaagccttc atttaatctc   2160

tgcagttcat ctcatttcaa atgtttatgg aagaagcact tcattgaaag tagtgctgta   2220

aatattctgc cataggaata ctgtctacat gctttctcat tcaagaattc gtcatcacgc   2280

atcacaggcc gcgtctttga cggtgggtgt cccattttta tccgctactc tttatttcat   2340

ggagtcgtat caacgctatg aacgcaaggc tgtgatatgg aaccagaagg ctgtctgaac   2400

ttttgaaacc ttgtgtggga ttgatggtgg tgccgaggca tgaaaggcta gtatgagcga   2460

gaaaaggaga gagcgcgtgc agagacttgg tggtgcataa tggatatttt ttaacttggc   2520

gagatgtgtc tctcaatcct gtggctttgg tgagagagtg tgcagagagc aatgatagca   2580

aataatgtac gaatgttttt tgcattcaaa ggacatccac atctgttgga agacttttaa   2640

gtgagttttt gttcttagat aacccacatt agatgaatgt gttaagtgaa atgatacttg   2700

tactccccct acccctttgt caactgctgt gaatgctgta tggtgtgtgt tctcttctgt   2760

tactgatatg taagtgtggc aatgtgaact gaagctgatg ggctgagaac atggactgag   2820

cttgtggtgt gctttgcagg aggacttgaa gcagagttca ccagtgagct caggtgtctc   2880

aaagaagggt ggaagttcta atgtctgtta gctacccata agaatgctgt ttgctgcagt   2940

tctgtgtcct gtgcttggat gctttttata agagttgtca ttgttggaaa ttcttaaata   3000

aaactgattt aaataatatg tgtctttgtt ttgcagccct gaatgcaaag aattcatagc   3060

agttaattcc ccttttttga cccttttgag atggaacttt cataaagttt cttggcagta   3120

gtttattttg cttcaaataa acttatttga aaagttgtct caagtcaaat ggattcatca   3180

cctgtcatgc attgacacct gatacccaga cttaattggt atttgttctt gcattggcca   3240

aagtgaaaat tttttttttt cttttgaaat ctagttttga ataagtctgg gtgaccgcac   3300

ctaaaatggt aagcagtacc ctccggcttt ttcttagtgc ctctgtgcat ttgggtgatg   3360

ttctatttac atggcctgtg taaatctcca ttgggaagtc atgccttcta aaaagattct   3420

tatttggggg agtgggcaaa atgttgatta ttttctaatg ctttgtagca aagcatatca   3480

attgaaaagg gaatatcagc accttcctag tttgggattt gaaaagtgga attaattgca   3540

gtagggataa agtagaagaa accacaaatt atcttgtgcc tgaaatccat taagaggcct   3600

gatagcttta agaattaggg tgggttgtct gtctggaagt gttaagtgga atgggctttg   3660

tcctccagga ggtgggggaa tgtggtaaca ttgaatacag ttgaataaaa tcgcttacaa   3720

aactcacact ctcacaatgc attgttaagt atgtaaaagc aataacattg attctctgtt   3780

gtactttttt gtaactaatt ctgtgagagt tgagctcatt ttctagttgg aagaatgtga   3840

tatttgttgt gttggtagtt tacctaatgc ccttacctaa ttagattatg ataaataggt   3900

ttgtcatttt gcaagttaca taaacattta tcaatgaagt catcctttag acttgtaatc   3960

gccacattgt ttcattattc agtttcctct gtaaagggat cttgagttgt tttaattttt   4020

tttttctgca tctgaatctg catgatttcc aaaccctgta ccatctgaat tttgcatttt   4080

agcacttgca ctattactca gcagcagtaa catggtaaca cttaaaatgg tactcgggga   4140

cctccaaaga ctaaactgac aagccttcaa ggagcccagg ggtaagttaa cttgtcaacg   4200

gcatggttta atcccttctt tacacttgtg taaatttcag ttactggtca tagaaggctt   4260

tcaatgttga gtggcctttt attaacatgt ttatggtact gcatagatac gggtatttat   4320

tttaccctaa gaagattttg aagtttaaaa gtacttaaac tatttggcaa agatttgttt   4380

ttaaaaatct atttggtcaa tctaaatgca ttcattctaa aaaatttttt gaaccagata   4440

aataaaattt ttttttgaca ccacagttta gtgtctggag tcttactgga aaaacacgat   4500

ttctttttat atgtgatata cagatgctgg aaagttacct ttaaaaattg agtctctaaa   4560

g                                                                   4561


<210>  1394
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  1394

Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
1               5                   10                  15


Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            20                  25                  30


Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        35                  40                  45


Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    50                  55                  60


Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Val 
65                  70                  75                  80


<210>  1395
<211>  2720
<212>  DNA
<213>  Homo sapiens

<400>  1395
tgattttgtt atatccctta ccttaatgtt tttttcattg ttcataacat atttctgagt     60

ttttttcttc cttttgattt gatcagcaaa gccaagatga gccaccacgc ctggccagtt    120

ttttgtatct ttagtagata acggggtttc actgttttga tctggctggt cttgaactcc    180

tgacctcagg tgatccaccc ccctcagcct cccaaagtgc tgggattaca ggcgtgagcc    240

actgctcctg ctcccggccc attttttaaa ttattatttt gagacagggt ctcactctgt    300

tgcccaggct ggtggaacac agtggtgtaa tcatagctca ctacacccta gaactcctgg    360

gctcagcctc cagggggagg atcctccagc ttcagcctcc caagtagcta ggacagatgc    420

atgccactac gcccagctaa tgtggctttt ttgtggtttt ttttgataga ggtggggtct    480

ccctgtgttg tctaggctgc caggctagtc ttgaactatt ggcctcacac agtcctccca    540

ccttggcctc ccaaagcgct aggattacag gcatgagcca ccatgcccag cctatgtctt    600

ttgaaaatcg actgaaatat cactgctgct gttaataaaa ctaaaagctg tattgggggt    660

ttaaatgaaa tgagtgttca ttgcttattt ttcctctggc tttagataaa ttaatgcttg    720

taatctaagt tttgttgcta ctttaaatat atgaatcagt ggtttaatct tctttgttta    780

catcccttat ttcttataga ttgcgcagtc tctttgtgga gaggacttga tcattaaagg    840

aatcagcgtt catatatcca atgccgaacc taagcacaat agcaatagac agttagaaag    900

aagtggaaga tttggtggta atccaggtgg ctttgggaat cagggtggat ttggtaatag    960

cagagggggt ggagctggtt tgggaaacaa tcaaggtagt aatatgggtg gtgggatgaa   1020

ctttggtgcg ttcagcatta atccagccat gatggctgcc gcccaggcag cactacagag   1080

cagttggggt atgatgggca tgttagccag ccagcagaac cagtcaggcc catcgggtaa   1140

taaccaaaac caaggcaaca tgcagaggga gccaaaccag gccttcggtt ctggaaataa   1200

ctcttatagt ggctctaatt ctggtgcagc aattggttgg ggatcagcat ccaatgcagg   1260

gtcgggcagt ggttttaatg gaggctttgg ctcaagcatg gattctaagt cttctggctg   1320

gggaatgtag acagtggggt tgtggttggt tggtatagaa tggtgggaat tcaaattttt   1380

ctaaactcat ggtaagtata ttgtaaaata catatgtact aagaattttc aaaattggtt   1440

tgttcagtgt ggagtatatt cagcagtatt tttgacattt ttctttagaa aaaggaagag   1500

ctaaaggaat tttataagtt ttgttacatg aaaggttgaa atattgagtg gttgaaagtg   1560

aactgctgtt tgcctgattg gtaaaccaac acactacaat tgatatcaaa aggtttctcc   1620

tgtaatattt tatccctgga cttgtcaagt gaattctttg catgttcaaa acggaaacca   1680

ttgattagaa ctacattctt taccccttgt tttaatttga accccaccat atggattttt   1740

ttccttaaga aaatctcctt ttaggagatc atggtgtcac agtgtttggt tcttttgttt   1800

tgttttttaa cacttgtctc ccctcataca caaaagtaca atatgaagcc ttcatttaat   1860

ctctgcagtt catctcattt caaatgttta tggaagaagc acttcattga aagtagtgct   1920

gtaaatattc tgccatagga atactgtcta catgctttct cattcaagaa ttcgtcatca   1980

cgcatcacag gccgcgtctt tgacggtggg tgtcccattt ttatccgcta ctctttattt   2040

catggagtcg tatcaacgct atgaacgcaa ggctgtgata tggaaccaga aggctgtctg   2100

aacttttgaa accttgtgtg ggattgatgg tggtgccgag gcatgaaagg ctagtatgag   2160

cgagaaaagg agagagcgcg tgcagagact tggtggtgca taatggatat tttttaactt   2220

ggcgagatgt gtctctcaat cctgtggctt tggtgagaga gtgtgcagag agcaatgata   2280

gcaaataatg tacgaatgtt ttttgcattc aaaggacatc cacatctgtt ggaagacttt   2340

taagtgagtt tttgttctta gataacccac attagatgaa tgtgttaagt gaaatgatac   2400

ttgtactccc cctacccctt tgtcaactgc tgtgaatgct gtatggtgtg tgttctcttc   2460

tgttactgat atgtaagtgt ggcaatgtga actgaagctg atgggctgag aacatggact   2520

gagcttgtgg tgtgctttgc aggaggactt gaagcagagt tcaccagtga gctcaggtgt   2580

ctcaaagaag ggtggaagtt ctaatgtctg ttagctaccc ataagaatgc tgtttgctgc   2640

agttctgtgt cctgtgcttg gatgcttttt ataagagttg tcattgttgg aaattcttaa   2700

ataaaactga tttaaataat                                               2720


<210>  1396
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  1396

Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro Ala Met 
1               5                   10                  15


Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met Met Gly 
            20                  25                  30


Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn Asn Gln 
        35                  40                  45


Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly Ser Gly 
    50                  55                  60


Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly Trp Gly 
65                  70                  75                  80


Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly Phe Gly 
                85                  90                  95


Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
            100                 105


<210>  1397
<211>  4167
<212>  DNA
<213>  Homo sapiens

<400>  1397
tgattttgtt atatccctta ccttaatgtt tttttcattg ttcataacat atttctgagt     60

ttttttcttc cttttgattt gatcagcaaa gccaagatga gccaccacgc ctggccagtt    120

ttttgtatct ttagtagata acggggtttc actgttttga tctggctggt cttgaactcc    180

tgacctcagg tgatccaccc ccctcagcct cccaaagtgc tgggattaca ggcgtgagcc    240

actgctcctg ctcccggccc attttttaaa ttattatttt gagacagggt ctcactctgt    300

tgcccaggct ggtggaacac agtggtgtaa tcatagctca ctacacccta gaactcctgg    360

gctcagcctc cagggggagg atcctccagc ttcagcctcc caagtagcta ggacagatgc    420

atgccactac gcccagctaa tgtggctttt ttgtggtttt ttttgataga ggtggggtct    480

ccctgtgttg tctaggctgc caggctagtc ttgaactatt ggcctcacac agtcctccca    540

ccttggcctc ccaaagcgct aggattacag gcatgagcca ccatgcccag cctatgtctt    600

ttgaaaatcg actgaaatat cactgctgct gttaataaaa ctaaaagctg tattgggggt    660

ttaaatgaaa tgagtgttca ttgcttattt ttcctctggc tttagataaa ttaatgcttg    720

taatctaagt tttgttgcta ctttaaatat atgaatcagt ggtttaatct tctttgttta    780

catcccttat ttcttataga ttgcgcagtc tctttgtgga gaggacttga tcattaaagg    840

aatcagcgtt catatatcca atgccgaacc taagcacaat agcaatagac agttagaaag    900

aagtggaaga tttggtggta atccaggtgg ctttgggaat cagggtggat ttggtaatag    960

cagagggggt ggagctggtt tgggaaacaa tcaaggtagt aatatgggtg gtgggatgaa   1020

ctttggtgcg ttcagcatta atccagccat gatggctgcc gcccaggcag cactacagag   1080

cagttggggt atgatgggca tgttagccag ccagcagaac cagtcaggcc catcgggtaa   1140

taaccaaaac caaggcaaca tgcagaggga gccaaaccag gccttcggtt ctggaaataa   1200

ctcttatagt ggctctaatt ctggtgcagc aattggttgg ggatcagcat ccaatgcagg   1260

gtcgggcagt ggttttaatg gaggctttgg ctcaagcatg gattctaagt cttctggctg   1320

gggaatgtag acagtggggt tgtggttggt tggtatagaa tggtgggaat tcaaattttt   1380

ctaaactcat ggtaagtata ttgtaaaata catatgtact aagaattttc aaaattggtt   1440

tgttcagtgt ggagtatatt cagcagtatt tttgacattt ttctttagaa aaaggaagag   1500

ctaaaggaat tttataagtt ttgttacatg aaaggttgaa atattgagtg gttgaaagtg   1560

aactgctgtt tgcctgattg gtaaaccaac acactacaat tgatatcaaa aggtttctcc   1620

tgtaatattt tatccctgga cttgtcaagt gaattctttg catgttcaaa acggaaacca   1680

ttgattagaa ctacattctt taccccttgt tttaatttga accccaccat atggattttt   1740

ttccttaaga aaatctcctt ttaggagatc atggtgtcac agtgtttggt tcttttgttt   1800

tgttttttaa cacttgtctc ccctcataca caaaagtaca atatgaagcc ttcatttaat   1860

ctctgcagtt catctcattt caaatgttta tggaagaagc acttcattga aagtagtgct   1920

gtaaatattc tgccatagga atactgtcta catgctttct cattcaagaa ttcgtcatca   1980

cgcatcacag gccgcgtctt tgacggtggg tgtcccattt ttatccgcta ctctttattt   2040

catggagtcg tatcaacgct atgaacgcaa ggctgtgata tggaaccaga aggctgtctg   2100

aacttttgaa accttgtgtg ggattgatgg tggtgccgag gcatgaaagg ctagtatgag   2160

cgagaaaagg agagagcgcg tgcagagact tggtggtgca taatggatat tttttaactt   2220

ggcgagatgt gtctctcaat cctgtggctt tggtgagaga gtgtgcagag agcaatgata   2280

gcaaataatg tacgaatgtt ttttgcattc aaaggacatc cacatctgtt ggaagacttt   2340

taagtgagtt tttgttctta gataacccac attagatgaa tgtgttaagt gaaatgatac   2400

ttgtactccc cctacccctt tgtcaactgc tgtgaatgct gtatggtgtg tgttctcttc   2460

tgttactgat atgtaagtgt ggcaatgtga actgaagctg atgggctgag aacatggact   2520

gagcttgtgg tgtgctttgc aggaggactt gaagcagagt tcaccagtga gctcaggtgt   2580

ctcaaagaag ggtggaagtt ctaatgtctg ttagctaccc ataagaatgc tgtttgctgc   2640

agttctgtgt cctgtgcttg gatgcttttt ataagagttg tcattgttgg aaattcttaa   2700

ataaaactga tttaaataat atgtgtcttt gttttgcagc cctgaatgca aagaattcat   2760

agcagttaat tccccttttt tgaccctttt gagatggaac tttcataaag tttcttggca   2820

gtagtttatt ttgcttcaaa taaacttatt tgaaaagttg tctcaagtca aatggattca   2880

tcacctgtca tgcattgaca cctgataccc agacttaatt ggtatttgtt cttgcattgg   2940

ccaaagtgaa aatttttttt tttcttttga aatctagttt tgaataagtc tgggtgaccg   3000

cacctaaaat ggtaagcagt accctccggc tttttcttag tgcctctgtg catttgggtg   3060

atgttctatt tacatggcct gtgtaaatct ccattgggaa gtcatgcctt ctaaaaagat   3120

tcttatttgg gggagtgggc aaaatgttga ttattttcta atgctttgta gcaaagcata   3180

tcaattgaaa agggaatatc agcaccttcc tagtttggga tttgaaaagt ggaattaatt   3240

gcagtaggga taaagtagaa gaaaccacaa attatcttgt gcctgaaatc cattaagagg   3300

cctgatagct ttaagaatta gggtgggttg tctgtctgga agtgttaagt ggaatgggct   3360

ttgtcctcca ggaggtgggg gaatgtggta acattgaata cagttgaata aaatcgctta   3420

caaaactcac actctcacaa tgcattgtta agtatgtaaa agcaataaca ttgattctct   3480

gttgtacttt tttgtaacta attctgtgag agttgagctc attttctagt tggaagaatg   3540

tgatatttgt tgtgttggta gtttacctaa tgcccttacc taattagatt atgataaata   3600

ggtttgtcat tttgcaagtt acataaacat ttatcaatga agtcatcctt tagacttgta   3660

atcgccacat tgtttcatta ttcagtttcc tctgtaaagg gatcttgagt tgttttaatt   3720

ttttttttct gcatctgaat ctgcatgatt tccaaaccct gtaccatctg aattttgcat   3780

tttagcactt gcactattac tcagcagcag taacatggta acacttaaaa tggtactcgg   3840

ggacctccaa agactaaact gacaagcctt caaggagccc aggggtaagt taacttgtca   3900

acggcatggt ttaatccctt ctttacactt gtgtaaattt cagttactgg tcatagaagg   3960

ctttcaatgt tgagtggcct tttattaaca tgtttatggt actgcataga tacgggtatt   4020

tattttaccc taagaagatt ttgaagttta aaagtactta aactatttgg caaagatttg   4080

tttttaaaaa tctatttggt caatctaaat gcattcattc taaaaaattt tttgaaccag   4140

ataaataaaa tttttttttg acaccac                                       4167


<210>  1398
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  1398

Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro Ala Met 
1               5                   10                  15


Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met Met Gly 
            20                  25                  30


Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn Asn Gln 
        35                  40                  45


Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly Ser Gly 
    50                  55                  60


Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly Trp Gly 
65                  70                  75                  80


Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly Phe Gly 
                85                  90                  95


Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
            100                 105


<210>  1399
<211>  4264
<212>  DNA
<213>  Homo sapiens

<400>  1399
tgattttgtt atatccctta ccttaatgtt tttttcattg ttcataacat atttctgagt     60

ttttttcttc cttttgattt gatcagcaaa gccaagatga gccaccacgc ctggccagtt    120

ttttgtatct ttagtagata acggggtttc actgttttga tctggctggt cttgaactcc    180

tgacctcagg tgatccaccc ccctcagcct cccaaagtgc tgggattaca ggcgtgagcc    240

actgctcctg ctcccggccc attttttaaa ttattatttt gagacagggt ctcactctgt    300

tgcccaggct ggtggaacac agtggtgtaa tcatagctca ctacacccta gaactcctgg    360

gctcagcctc cagggggagg atcctccagc ttcagcctcc caagtagcta ggacagatgc    420

atgccactac gcccagctaa tgtggctttt ttgtggtttt ttttgataga ggtggggtct    480

ccctgtgttg tctaggctgc caggctagtc ttgaactatt ggcctcacac agtcctccca    540

ccttggcctc ccaaagcgct aggattacag gcatgagcca ccatgcccag cctatgtctt    600

ttgaaaatcg actgaaatat cactgctgct gttaataaaa ctaaaagctg tattgggggt    660

ttaaatgaaa tgagtgttca ttgcttattt ttcctctggc tttagataaa ttaatgcttg    720

taatctaagt tttgttgcta ctttaaatat atgaatcagt ggtttaatct tctttgttta    780

catcccttat ttcttataga ttgcgcagtc tctttgtgga gaggacttga tcattaaagg    840

aatcagcgtt catatatcca atgccgaacc taagcacaat agcaatagac agttagaaag    900

aagtggaaga tttggtggta atccaggtgg ctttgggaat cagggtggat ttggtaatag    960

cagagggggt ggagctggtt tgggaaacaa tcaaggtagt aatatgggtg gtgggatgaa   1020

ctttggtgcg ttcagcatta atccagccat gatggctgcc gcccaggcag cactacagag   1080

cagttggggt atgatgggca tgttagccag ccagcagaac cagtcaggcc catcgggtaa   1140

taaccaaaac caaggcaaca tgcagaggga gccaaaccag gccttcggtt ctggaaataa   1200

ctcttatagt ggctctaatt ctggtgcagc aattggttgg ggatcagcat ccaatgcagg   1260

gtcgggcagt ggttttaatg gaggctttgg ctcaagcatg gattctaagt cttctggctg   1320

gggaatgtag acagtggggt tgtggttggt tggtatagaa tggtgggaat tcaaattttt   1380

ctaaactcat ggtaagtata ttgtaaaata catatgtact aagaattttc aaaattggtt   1440

tgttcagtgt ggagtatatt cagcagtatt tttgacattt ttctttagaa aaaggaagag   1500

ctaaaggaat tttataagtt ttgttacatg aaaggttgaa atattgagtg gttgaaagtg   1560

aactgctgtt tgcctgattg gtaaaccaac acactacaat tgatatcaaa aggtttctcc   1620

tgtaatattt tatccctgga cttgtcaagt gaattctttg catgttcaaa acggaaacca   1680

ttgattagaa ctacattctt taccccttgt tttaatttga accccaccat atggattttt   1740

ttccttaaga aaatctcctt ttaggagatc atggtgtcac agtgtttggt tcttttgttt   1800

tgttttttaa cacttgtctc ccctcataca caaaagtaca atatgaagcc ttcatttaat   1860

ctctgcagtt catctcattt caaatgttta tggaagaagc acttcattga aagtagtgct   1920

gtaaatattc tgccatagga atactgtcta catgctttct cattcaagaa ttcgtcatca   1980

cgcatcacag gccgcgtctt tgacggtggg tgtcccattt ttatccgcta ctctttattt   2040

catggagtcg tatcaacgct atgaacgcaa ggctgtgata tggaaccaga aggctgtctg   2100

aacttttgaa accttgtgtg ggattgatgg tggtgccgag gcatgaaagg ctagtatgag   2160

cgagaaaagg agagagcgcg tgcagagact tggtggtgca taatggatat tttttaactt   2220

ggcgagatgt gtctctcaat cctgtggctt tggtgagaga gtgtgcagag agcaatgata   2280

gcaaataatg tacgaatgtt ttttgcattc aaaggacatc cacatctgtt ggaagacttt   2340

taagtgagtt tttgttctta gataacccac attagatgaa tgtgttaagt gaaatgatac   2400

ttgtactccc cctacccctt tgtcaactgc tgtgaatgct gtatggtgtg tgttctcttc   2460

tgttactgat atgtaagtgt ggcaatgtga actgaagctg atgggctgag aacatggact   2520

gagcttgtgg tgtgctttgc aggaggactt gaagcagagt tcaccagtga gctcaggtgt   2580

ctcaaagaag ggtggaagtt ctaatgtctg ttagctaccc ataagaatgc tgtttgctgc   2640

agttctgtgt cctgtgcttg gatgcttttt ataagagttg tcattgttgg aaattcttaa   2700

ataaaactga tttaaataat atgtgtcttt gttttgcagc cctgaatgca aagaattcat   2760

agcagttaat tccccttttt tgaccctttt gagatggaac tttcataaag tttcttggca   2820

gtagtttatt ttgcttcaaa taaacttatt tgaaaagttg tctcaagtca aatggattca   2880

tcacctgtca tgcattgaca cctgataccc agacttaatt ggtatttgtt cttgcattgg   2940

ccaaagtgaa aatttttttt tttcttttga aatctagttt tgaataagtc tgggtgaccg   3000

cacctaaaat ggtaagcagt accctccggc tttttcttag tgcctctgtg catttgggtg   3060

atgttctatt tacatggcct gtgtaaatct ccattgggaa gtcatgcctt ctaaaaagat   3120

tcttatttgg gggagtgggc aaaatgttga ttattttcta atgctttgta gcaaagcata   3180

tcaattgaaa agggaatatc agcaccttcc tagtttggga tttgaaaagt ggaattaatt   3240

gcagtaggga taaagtagaa gaaaccacaa attatcttgt gcctgaaatc cattaagagg   3300

cctgatagct ttaagaatta gggtgggttg tctgtctgga agtgttaagt ggaatgggct   3360

ttgtcctcca ggaggtgggg gaatgtggta acattgaata cagttgaata aaatcgctta   3420

caaaactcac actctcacaa tgcattgtta agtatgtaaa agcaataaca ttgattctct   3480

gttgtacttt tttgtaacta attctgtgag agttgagctc attttctagt tggaagaatg   3540

tgatatttgt tgtgttggta gtttacctaa tgcccttacc taattagatt atgataaata   3600

ggtttgtcat tttgcaagtt acataaacat ttatcaatga agtcatcctt tagacttgta   3660

atcgccacat tgtttcatta ttcagtttcc tctgtaaagg gatcttgagt tgttttaatt   3720

ttttttttct gcatctgaat ctgcatgatt tccaaaccct gtaccatctg aattttgcat   3780

tttagcactt gcactattac tcagcagcag taacatggta acacttaaaa tggtactcgg   3840

ggacctccaa agactaaact gacaagcctt caaggagccc aggggtaagt taacttgtca   3900

acggcatggt ttaatccctt ctttacactt gtgtaaattt cagttactgg tcatagaagg   3960

ctttcaatgt tgagtggcct tttattaaca tgtttatggt actgcataga tacgggtatt   4020

tattttaccc taagaagatt ttgaagttta aaagtactta aactatttgg caaagatttg   4080

tttttaaaaa tctatttggt caatctaaat gcattcattc taaaaaattt tttgaaccag   4140

ataaataaaa tttttttttg acaccacagt ttagtgtctg gagtcttact ggaaaaacac   4200

gatttctttt tatatgtgat atacagatgc tggaaagtta cctttaaaaa ttgagtctct   4260

aaag                                                                4264


<210>  1400
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  1400

Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro Ala Met 
1               5                   10                  15


Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met Met Gly 
            20                  25                  30


Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn Asn Gln 
        35                  40                  45


Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly Ser Gly 
    50                  55                  60


Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly Trp Gly 
65                  70                  75                  80


Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly Phe Gly 
                85                  90                  95


Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
            100                 105


<210>  1401
<211>  1976
<212>  DNA
<213>  Homo sapiens

<400>  1401
ggattacagg catgagccac catgcccagc ctatgtcttt tgaaaatcga ctgaaatatc     60

actgctgctg ttaataaaac taaaagctgt attgggggtt taaatgaaat gagtgttcat    120

tgcttatttt tcctctggct ttagataaat taatgcttgt aatctaagtt ttgttgctac    180

tttaaatata tgaatcagtg gtttaatctt ctttgtttac atcccttatt tcttatagat    240

tgcgcagtct ctttgtggag aggacttgat cattaaagga atcagcgttc atatatccaa    300

tgccgaacct aagcacaata gcaatagaca gttagaaaga agtggaagat ttggtggtaa    360

tccaggtggc tttgggaatc agggtggatt tggtaataac caaaaccaag gcaacatgca    420

gagggagcca aaccaggcct tcggttctgg aaataactct tatagtggct ctaattctgg    480

tgcagcaatt ggttggggat cagcatccaa tgcagggtcg ggcagtggtt ttaatggagg    540

ctttggctca agcatggatt ctaagtcttc tggctgggga atgtagacag tggggttgtg    600

gttggttggt atagaatggt gggaattcaa atttttctaa actcatggta agtatattgt    660

aaaatacata tgtactaaga attttcaaaa ttggtttgtt cagtgtggag tatattcagc    720

agtatttttg acatttttct ttagaaaaag gaagagctaa aggaatttta taagttttgt    780

tacatgaaag gttgaaatat tgagtggttg aaagtgaact gctgtttgcc tgattggtaa    840

accaacacac tacaattgat atcaaaaggt ttctcctgta atattttatc cctggacttg    900

tcaagtgaat tctttgcatg ttcaaaacgg aaaccattga ttagaactac attctttacc    960

ccttgtttta atttgaaccc caccatatgg atttttttcc ttaagaaaat ctccttttag   1020

gagatcatgg tgtcacagtg tttggttctt ttgttttgtt ttttaacact tgtctcccct   1080

catacacaaa agtacaatat gaagccttca tttaatctct gcagttcatc tcatttcaaa   1140

tgtttatgga agaagcactt cattgaaagt agtgctgtaa atattctgcc ataggaatac   1200

tgtctacatg ctttctcatt caagaattcg tcatcacgca tcacaggccg cgtctttgac   1260

ggtgggtgtc ccatttttat ccgctactct ttatttcatg gagtcgtatc aacgctatga   1320

acgcaaggct gtgatatgga accagaaggc tgtctgaact tttgaaacct tgtgtgggat   1380

tgatggtggt gccgaggcat gaaaggctag tatgagcgag aaaaggagag agcgcgtgca   1440

gagacttggt ggtgcataat ggatattttt taacttggcg agatgtgtct ctcaatcctg   1500

tggctttggt gagagagtgt gcagagagca atgatagcaa ataatgtacg aatgtttttt   1560

gcattcaaag gacatccaca tctgttggaa gacttttaag tgagtttttg ttcttagata   1620

acccacatta gatgaatgtg ttaagtgaaa tgatacttgt actcccccta cccctttgtc   1680

aactgctgtg aatgctgtat ggtgtgtgtt ctcttctgtt actgatatgt aagtgtggca   1740

atgtgaactg aagctgatgg gctgagaaca tggactgagc ttgtggtgtg ctttgcagga   1800

ggacttgaag cagagttcac cagtgagctc aggtgtctca aagaagggtg gaagttctaa   1860

tgtctgttag ctacccataa gaatgctgtt tgctgcagtt ctgtgtcctg tgcttggatg   1920

ctttttataa gagttgtcat tgttggaaat tcttaaataa aactgattta aataat       1976


<210>  1402
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  1402

Met Gln Arg Glu Pro Asn Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr 
1               5                   10                  15


Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn 
            20                  25                  30


Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly Phe Gly Ser Ser Met Asp 
        35                  40                  45


Ser Lys Ser Ser Gly Trp Gly Met 
    50                  55


<210>  1403
<211>  3423
<212>  DNA
<213>  Homo sapiens

<400>  1403
ggattacagg catgagccac catgcccagc ctatgtcttt tgaaaatcga ctgaaatatc     60

actgctgctg ttaataaaac taaaagctgt attgggggtt taaatgaaat gagtgttcat    120

tgcttatttt tcctctggct ttagataaat taatgcttgt aatctaagtt ttgttgctac    180

tttaaatata tgaatcagtg gtttaatctt ctttgtttac atcccttatt tcttatagat    240

tgcgcagtct ctttgtggag aggacttgat cattaaagga atcagcgttc atatatccaa    300

tgccgaacct aagcacaata gcaatagaca gttagaaaga agtggaagat ttggtggtaa    360

tccaggtggc tttgggaatc agggtggatt tggtaataac caaaaccaag gcaacatgca    420

gagggagcca aaccaggcct tcggttctgg aaataactct tatagtggct ctaattctgg    480

tgcagcaatt ggttggggat cagcatccaa tgcagggtcg ggcagtggtt ttaatggagg    540

ctttggctca agcatggatt ctaagtcttc tggctgggga atgtagacag tggggttgtg    600

gttggttggt atagaatggt gggaattcaa atttttctaa actcatggta agtatattgt    660

aaaatacata tgtactaaga attttcaaaa ttggtttgtt cagtgtggag tatattcagc    720

agtatttttg acatttttct ttagaaaaag gaagagctaa aggaatttta taagttttgt    780

tacatgaaag gttgaaatat tgagtggttg aaagtgaact gctgtttgcc tgattggtaa    840

accaacacac tacaattgat atcaaaaggt ttctcctgta atattttatc cctggacttg    900

tcaagtgaat tctttgcatg ttcaaaacgg aaaccattga ttagaactac attctttacc    960

ccttgtttta atttgaaccc caccatatgg atttttttcc ttaagaaaat ctccttttag   1020

gagatcatgg tgtcacagtg tttggttctt ttgttttgtt ttttaacact tgtctcccct   1080

catacacaaa agtacaatat gaagccttca tttaatctct gcagttcatc tcatttcaaa   1140

tgtttatgga agaagcactt cattgaaagt agtgctgtaa atattctgcc ataggaatac   1200

tgtctacatg ctttctcatt caagaattcg tcatcacgca tcacaggccg cgtctttgac   1260

ggtgggtgtc ccatttttat ccgctactct ttatttcatg gagtcgtatc aacgctatga   1320

acgcaaggct gtgatatgga accagaaggc tgtctgaact tttgaaacct tgtgtgggat   1380

tgatggtggt gccgaggcat gaaaggctag tatgagcgag aaaaggagag agcgcgtgca   1440

gagacttggt ggtgcataat ggatattttt taacttggcg agatgtgtct ctcaatcctg   1500

tggctttggt gagagagtgt gcagagagca atgatagcaa ataatgtacg aatgtttttt   1560

gcattcaaag gacatccaca tctgttggaa gacttttaag tgagtttttg ttcttagata   1620

acccacatta gatgaatgtg ttaagtgaaa tgatacttgt actcccccta cccctttgtc   1680

aactgctgtg aatgctgtat ggtgtgtgtt ctcttctgtt actgatatgt aagtgtggca   1740

atgtgaactg aagctgatgg gctgagaaca tggactgagc ttgtggtgtg ctttgcagga   1800

ggacttgaag cagagttcac cagtgagctc aggtgtctca aagaagggtg gaagttctaa   1860

tgtctgttag ctacccataa gaatgctgtt tgctgcagtt ctgtgtcctg tgcttggatg   1920

ctttttataa gagttgtcat tgttggaaat tcttaaataa aactgattta aataatatgt   1980

gtctttgttt tgcagccctg aatgcaaaga attcatagca gttaattccc cttttttgac   2040

ccttttgaga tggaactttc ataaagtttc ttggcagtag tttattttgc ttcaaataaa   2100

cttatttgaa aagttgtctc aagtcaaatg gattcatcac ctgtcatgca ttgacacctg   2160

atacccagac ttaattggta tttgttcttg cattggccaa agtgaaaatt tttttttttc   2220

ttttgaaatc tagttttgaa taagtctggg tgaccgcacc taaaatggta agcagtaccc   2280

tccggctttt tcttagtgcc tctgtgcatt tgggtgatgt tctatttaca tggcctgtgt   2340

aaatctccat tgggaagtca tgccttctaa aaagattctt atttggggga gtgggcaaaa   2400

tgttgattat tttctaatgc tttgtagcaa agcatatcaa ttgaaaaggg aatatcagca   2460

ccttcctagt ttgggatttg aaaagtggaa ttaattgcag tagggataaa gtagaagaaa   2520

ccacaaatta tcttgtgcct gaaatccatt aagaggcctg atagctttaa gaattagggt   2580

gggttgtctg tctggaagtg ttaagtggaa tgggctttgt cctccaggag gtgggggaat   2640

gtggtaacat tgaatacagt tgaataaaat cgcttacaaa actcacactc tcacaatgca   2700

ttgttaagta tgtaaaagca ataacattga ttctctgttg tacttttttg taactaattc   2760

tgtgagagtt gagctcattt tctagttgga agaatgtgat atttgttgtg ttggtagttt   2820

acctaatgcc cttacctaat tagattatga taaataggtt tgtcattttg caagttacat   2880

aaacatttat caatgaagtc atcctttaga cttgtaatcg ccacattgtt tcattattca   2940

gtttcctctg taaagggatc ttgagttgtt ttaatttttt ttttctgcat ctgaatctgc   3000

atgatttcca aaccctgtac catctgaatt ttgcatttta gcacttgcac tattactcag   3060

cagcagtaac atggtaacac ttaaaatggt actcggggac ctccaaagac taaactgaca   3120

agccttcaag gagcccaggg gtaagttaac ttgtcaacgg catggtttaa tcccttcttt   3180

acacttgtgt aaatttcagt tactggtcat agaaggcttt caatgttgag tggcctttta   3240

ttaacatgtt tatggtactg catagatacg ggtatttatt ttaccctaag aagattttga   3300

agtttaaaag tacttaaact atttggcaaa gatttgtttt taaaaatcta tttggtcaat   3360

ctaaatgcat tcattctaaa aaattttttg aaccagataa ataaaatttt tttttgacac   3420

cac                                                                 3423


<210>  1404
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  1404

Met Gln Arg Glu Pro Asn Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr 
1               5                   10                  15


Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn 
            20                  25                  30


Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly Phe Gly Ser Ser Met Asp 
        35                  40                  45


Ser Lys Ser Ser Gly Trp Gly Met 
    50                  55


<210>  1405
<211>  3520
<212>  DNA
<213>  Homo sapiens

<400>  1405
ggattacagg catgagccac catgcccagc ctatgtcttt tgaaaatcga ctgaaatatc     60

actgctgctg ttaataaaac taaaagctgt attgggggtt taaatgaaat gagtgttcat    120

tgcttatttt tcctctggct ttagataaat taatgcttgt aatctaagtt ttgttgctac    180

tttaaatata tgaatcagtg gtttaatctt ctttgtttac atcccttatt tcttatagat    240

tgcgcagtct ctttgtggag aggacttgat cattaaagga atcagcgttc atatatccaa    300

tgccgaacct aagcacaata gcaatagaca gttagaaaga agtggaagat ttggtggtaa    360

tccaggtggc tttgggaatc agggtggatt tggtaataac caaaaccaag gcaacatgca    420

gagggagcca aaccaggcct tcggttctgg aaataactct tatagtggct ctaattctgg    480

tgcagcaatt ggttggggat cagcatccaa tgcagggtcg ggcagtggtt ttaatggagg    540

ctttggctca agcatggatt ctaagtcttc tggctgggga atgtagacag tggggttgtg    600

gttggttggt atagaatggt gggaattcaa atttttctaa actcatggta agtatattgt    660

aaaatacata tgtactaaga attttcaaaa ttggtttgtt cagtgtggag tatattcagc    720

agtatttttg acatttttct ttagaaaaag gaagagctaa aggaatttta taagttttgt    780

tacatgaaag gttgaaatat tgagtggttg aaagtgaact gctgtttgcc tgattggtaa    840

accaacacac tacaattgat atcaaaaggt ttctcctgta atattttatc cctggacttg    900

tcaagtgaat tctttgcatg ttcaaaacgg aaaccattga ttagaactac attctttacc    960

ccttgtttta atttgaaccc caccatatgg atttttttcc ttaagaaaat ctccttttag   1020

gagatcatgg tgtcacagtg tttggttctt ttgttttgtt ttttaacact tgtctcccct   1080

catacacaaa agtacaatat gaagccttca tttaatctct gcagttcatc tcatttcaaa   1140

tgtttatgga agaagcactt cattgaaagt agtgctgtaa atattctgcc ataggaatac   1200

tgtctacatg ctttctcatt caagaattcg tcatcacgca tcacaggccg cgtctttgac   1260

ggtgggtgtc ccatttttat ccgctactct ttatttcatg gagtcgtatc aacgctatga   1320

acgcaaggct gtgatatgga accagaaggc tgtctgaact tttgaaacct tgtgtgggat   1380

tgatggtggt gccgaggcat gaaaggctag tatgagcgag aaaaggagag agcgcgtgca   1440

gagacttggt ggtgcataat ggatattttt taacttggcg agatgtgtct ctcaatcctg   1500

tggctttggt gagagagtgt gcagagagca atgatagcaa ataatgtacg aatgtttttt   1560

gcattcaaag gacatccaca tctgttggaa gacttttaag tgagtttttg ttcttagata   1620

acccacatta gatgaatgtg ttaagtgaaa tgatacttgt actcccccta cccctttgtc   1680

aactgctgtg aatgctgtat ggtgtgtgtt ctcttctgtt actgatatgt aagtgtggca   1740

atgtgaactg aagctgatgg gctgagaaca tggactgagc ttgtggtgtg ctttgcagga   1800

ggacttgaag cagagttcac cagtgagctc aggtgtctca aagaagggtg gaagttctaa   1860

tgtctgttag ctacccataa gaatgctgtt tgctgcagtt ctgtgtcctg tgcttggatg   1920

ctttttataa gagttgtcat tgttggaaat tcttaaataa aactgattta aataatatgt   1980

gtctttgttt tgcagccctg aatgcaaaga attcatagca gttaattccc cttttttgac   2040

ccttttgaga tggaactttc ataaagtttc ttggcagtag tttattttgc ttcaaataaa   2100

cttatttgaa aagttgtctc aagtcaaatg gattcatcac ctgtcatgca ttgacacctg   2160

atacccagac ttaattggta tttgttcttg cattggccaa agtgaaaatt tttttttttc   2220

ttttgaaatc tagttttgaa taagtctggg tgaccgcacc taaaatggta agcagtaccc   2280

tccggctttt tcttagtgcc tctgtgcatt tgggtgatgt tctatttaca tggcctgtgt   2340

aaatctccat tgggaagtca tgccttctaa aaagattctt atttggggga gtgggcaaaa   2400

tgttgattat tttctaatgc tttgtagcaa agcatatcaa ttgaaaaggg aatatcagca   2460

ccttcctagt ttgggatttg aaaagtggaa ttaattgcag tagggataaa gtagaagaaa   2520

ccacaaatta tcttgtgcct gaaatccatt aagaggcctg atagctttaa gaattagggt   2580

gggttgtctg tctggaagtg ttaagtggaa tgggctttgt cctccaggag gtgggggaat   2640

gtggtaacat tgaatacagt tgaataaaat cgcttacaaa actcacactc tcacaatgca   2700

ttgttaagta tgtaaaagca ataacattga ttctctgttg tacttttttg taactaattc   2760

tgtgagagtt gagctcattt tctagttgga agaatgtgat atttgttgtg ttggtagttt   2820

acctaatgcc cttacctaat tagattatga taaataggtt tgtcattttg caagttacat   2880

aaacatttat caatgaagtc atcctttaga cttgtaatcg ccacattgtt tcattattca   2940

gtttcctctg taaagggatc ttgagttgtt ttaatttttt ttttctgcat ctgaatctgc   3000

atgatttcca aaccctgtac catctgaatt ttgcatttta gcacttgcac tattactcag   3060

cagcagtaac atggtaacac ttaaaatggt actcggggac ctccaaagac taaactgaca   3120

agccttcaag gagcccaggg gtaagttaac ttgtcaacgg catggtttaa tcccttcttt   3180

acacttgtgt aaatttcagt tactggtcat agaaggcttt caatgttgag tggcctttta   3240

ttaacatgtt tatggtactg catagatacg ggtatttatt ttaccctaag aagattttga   3300

agtttaaaag tacttaaact atttggcaaa gatttgtttt taaaaatcta tttggtcaat   3360

ctaaatgcat tcattctaaa aaattttttg aaccagataa ataaaatttt tttttgacac   3420

cacagtttag tgtctggagt cttactggaa aaacacgatt tctttttata tgtgatatac   3480

agatgctgga aagttacctt taaaaattga gtctctaaag                         3520


<210>  1406
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  1406

Met Gln Arg Glu Pro Asn Gln Ala Phe Gly Ser Gly Asn Asn Ser Tyr 
1               5                   10                  15


Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly Trp Gly Ser Ala Ser Asn 
            20                  25                  30


Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly Phe Gly Ser Ser Met Asp 
        35                  40                  45


Ser Lys Ser Ser Gly Trp Gly Met 
    50                  55


<210>  1407
<211>  1301
<212>  DNA
<213>  Homo sapiens

<400>  1407
acttgatcat taaaggaatc agcgttcata tatccaatgc cgaacctaag cacaatagca     60

atagacagtt agaaagaagt ggaagatttg gtggtaatcc aggtggcttt gggaatcagg    120

gtggatttgg taatagcaga gggggtggag ctggtttggg aaacaatcaa ggtagtaata    180

tgggtggtgg gatgaacttt ggtgcgttca gcattaatcc agccatgatg gctgccgccc    240

aggcagcact acagagcagt tggggtatga tgggcatgtt agccagccag cagaaccagt    300

caggcccatc gggtaataac caaaaccaag gcaacatgca gagggagcca aaccaggcct    360

tcggttctgg aaataactct tatagtggct ctaattctgg tgcagcaatt ggttggggat    420

cagcatccaa tgcagggtcg ggcagtggtt ttaatggagg ctttggctca agcatggatt    480

ctaagtcttc tggctgggga atgtagacag tggggttgtg gttggttggt atagaatggt    540

gggaattcaa atttttctaa actcatggta agtatattgt aaaatacata tgtactaaga    600

attttcaaaa ttggtttgtt cagtgtggag tatattcagc agtatttttg acatttttct    660

ttagaaaaag gaagagctaa aggaatttta taagttttgt tacatgaaag gttgaaatat    720

tgagtggttg aaagtgaact gctgtttgcc tgattggtaa accaacacac tacaattgat    780

atcaaaaggt ttctcctgta atattttatc cctggacttg tcaagtgaat tctttgcatg    840

ttcaaaacgg aaaccattga ttagaactac attctttacc ccttgtttta atttgaaccc    900

caccatatgg atttttttcc ttaagaaaat ctccttttag gagatcatgg tgtcacagtg    960

tttggttctt ttgttttgtt ttttaacact tgtctcccct catacacaaa agtacaatat   1020

gaagccttca tttaatctct gcagttcatc tcatttcaaa tgtttatgga agaagcactt   1080

cattgaaagt agtgctgtaa atattctgcc ataggaatac tgtctacatg ctttctcatt   1140

caagaattcg tcatcacgca tcacaggccg cgtctttgac gccctgaatg caaagaattc   1200

atagcagtta attccccttt tttgaccctt ttgagatgga actttcataa agtttcttgg   1260

cagtagttta ttttgcttca aataaactta tttgaaaagt t                       1301


<210>  1408
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  1408

Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro Ala Met 
1               5                   10                  15


Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met Met Gly 
            20                  25                  30


Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn Asn Gln 
        35                  40                  45


Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly Ser Gly 
    50                  55                  60


Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly Trp Gly 
65                  70                  75                  80


Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly Phe Gly 
                85                  90                  95


Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
            100                 105


<210>  1409
<211>  2609
<212>  DNA
<213>  Homo sapiens

<400>  1409
acttgatcat taaaggaatc agcgttcata tatccaatgc cgaacctaag cacaatagca     60

atagacagtt agaaagaagt ggaagatttg gtggtaatcc aggtggcttt gggaatcagg    120

gtggatttgg taatagcaga gggggtggag ctggtttggg aaacaatcaa ggtagtaata    180

tgggtggtgg gatgaacttt ggtgcgttca gcattaatcc agccatgatg gctgccgccc    240

aggcagcact acagagcagt tggggtatga tgggcatgtt agccagccag cagaaccagt    300

caggcccatc gggtaataac caaaaccaag gcaacatgca gagggagcca aaccaggcct    360

tcggttctgg aaataactct tatagtggct ctaattctgg tgcagcaatt ggttggggat    420

cagcatccaa tgcagggtcg ggcagtggtt ttaatggagg ctttggctca agcatggatt    480

ctaagtcttc tggctgggga atgtagacag tggggttgtg gttggttggt atagaatggt    540

gggaattcaa atttttctaa actcatggta agtatattgt aaaatacata tgtactaaga    600

attttcaaaa ttggtttgtt cagtgtggag tatattcagc agtatttttg acatttttct    660

ttagaaaaag gaagagctaa aggaatttta taagttttgt tacatgaaag gttgaaatat    720

tgagtggttg aaagtgaact gctgtttgcc tgattggtaa accaacacac tacaattgat    780

atcaaaaggt ttctcctgta atattttatc cctggacttg tcaagtgaat tctttgcatg    840

ttcaaaacgg aaaccattga ttagaactac attctttacc ccttgtttta atttgaaccc    900

caccatatgg atttttttcc ttaagaaaat ctccttttag gagatcatgg tgtcacagtg    960

tttggttctt ttgttttgtt ttttaacact tgtctcccct catacacaaa agtacaatat   1020

gaagccttca tttaatctct gcagttcatc tcatttcaaa tgtttatgga agaagcactt   1080

cattgaaagt agtgctgtaa atattctgcc ataggaatac tgtctacatg ctttctcatt   1140

caagaattcg tcatcacgca tcacaggccg cgtctttgac gccctgaatg caaagaattc   1200

atagcagtta attccccttt tttgaccctt ttgagatgga actttcataa agtttcttgg   1260

cagtagttta ttttgcttca aataaactta tttgaaaagt tgtctcaagt caaatggatt   1320

catcacctgt catgcattga cacctgatac ccagacttaa ttggtatttg ttcttgcatt   1380

ggccaaagtg aaaatttttt tttttctttt gaaatctagt tttgaataag tctgggtgac   1440

cgcacctaaa atggtaagca gtaccctccg gctttttctt agtgcctctg tgcatttggg   1500

tgatgttcta tttacatggc ctgtgtaaat ctccattggg aagtcatgcc ttctaaaaag   1560

attcttattt gggggagtgg gcaaaatgtt gattattttc taatgctttg tagcaaagca   1620

tatcaattga aaagggaata tcagcacctt cctagtttgg gatttgaaaa gtggaattaa   1680

ttgcagtagg gataaagtag aagaaaccac aaattatctt gtgcctgaaa tccattaaga   1740

ggcctgatag ctttaagaat tagggtgggt tgtctgtctg gaagtgttaa gtggaatggg   1800

ctttgtcctc caggaggtgg gggaatgtgg taacattgaa tacagttgaa taaaatcgct   1860

tacaaaactc acactctcac aatgcattgt taagtatgta aaagcaataa cattgattct   1920

ctgttgtact tttttgtaac taattctgtg agagttgagc tcattttcta gttggaagaa   1980

tgtgatattt gttgtgttgg tagtttacct aatgccctta cctaattaga ttatgataaa   2040

taggtttgtc attttgcaag ttacataaac atttatcaat gaagtcatcc tttagacttg   2100

taatcgccac attgtttcat tattcagttt cctctgtaaa gggatcttga gttgttttaa   2160

tttttttttt ctgcatctga atctgcatga tttccaaacc ctgtaccatc tgaattttgc   2220

attttagcac ttgcactatt actcagcagc agtaacatgg taacacttaa aatggtactc   2280

ggggacctcc aaagactaaa ctgacaagcc ttcaaggagc ccaggggtaa gttaacttgt   2340

caacggcatg gtttaatccc ttctttacac ttgtgtaaat ttcagttact ggtcatagaa   2400

ggctttcaat gttgagtggc cttttattaa catgtttatg gtactgcata gatacgggta   2460

tttattttac cctaagaaga ttttgaagtt taaaagtact taaactattt ggcaaagatt   2520

tgtttttaaa aatctatttg gtcaatctaa atgcattcat tctaaaaaat tttttgaacc   2580

agataaataa aatttttttt tgacaccac                                     2609


<210>  1410
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  1410

Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro Ala Met 
1               5                   10                  15


Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met Met Gly 
            20                  25                  30


Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn Asn Gln 
        35                  40                  45


Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly Ser Gly 
    50                  55                  60


Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly Trp Gly 
65                  70                  75                  80


Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly Phe Gly 
                85                  90                  95


Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
            100                 105


<210>  1411
<211>  2706
<212>  DNA
<213>  Homo sapiens

<400>  1411
acttgatcat taaaggaatc agcgttcata tatccaatgc cgaacctaag cacaatagca     60

atagacagtt agaaagaagt ggaagatttg gtggtaatcc aggtggcttt gggaatcagg    120

gtggatttgg taatagcaga gggggtggag ctggtttggg aaacaatcaa ggtagtaata    180

tgggtggtgg gatgaacttt ggtgcgttca gcattaatcc agccatgatg gctgccgccc    240

aggcagcact acagagcagt tggggtatga tgggcatgtt agccagccag cagaaccagt    300

caggcccatc gggtaataac caaaaccaag gcaacatgca gagggagcca aaccaggcct    360

tcggttctgg aaataactct tatagtggct ctaattctgg tgcagcaatt ggttggggat    420

cagcatccaa tgcagggtcg ggcagtggtt ttaatggagg ctttggctca agcatggatt    480

ctaagtcttc tggctgggga atgtagacag tggggttgtg gttggttggt atagaatggt    540

gggaattcaa atttttctaa actcatggta agtatattgt aaaatacata tgtactaaga    600

attttcaaaa ttggtttgtt cagtgtggag tatattcagc agtatttttg acatttttct    660

ttagaaaaag gaagagctaa aggaatttta taagttttgt tacatgaaag gttgaaatat    720

tgagtggttg aaagtgaact gctgtttgcc tgattggtaa accaacacac tacaattgat    780

atcaaaaggt ttctcctgta atattttatc cctggacttg tcaagtgaat tctttgcatg    840

ttcaaaacgg aaaccattga ttagaactac attctttacc ccttgtttta atttgaaccc    900

caccatatgg atttttttcc ttaagaaaat ctccttttag gagatcatgg tgtcacagtg    960

tttggttctt ttgttttgtt ttttaacact tgtctcccct catacacaaa agtacaatat   1020

gaagccttca tttaatctct gcagttcatc tcatttcaaa tgtttatgga agaagcactt   1080

cattgaaagt agtgctgtaa atattctgcc ataggaatac tgtctacatg ctttctcatt   1140

caagaattcg tcatcacgca tcacaggccg cgtctttgac gccctgaatg caaagaattc   1200

atagcagtta attccccttt tttgaccctt ttgagatgga actttcataa agtttcttgg   1260

cagtagttta ttttgcttca aataaactta tttgaaaagt tgtctcaagt caaatggatt   1320

catcacctgt catgcattga cacctgatac ccagacttaa ttggtatttg ttcttgcatt   1380

ggccaaagtg aaaatttttt tttttctttt gaaatctagt tttgaataag tctgggtgac   1440

cgcacctaaa atggtaagca gtaccctccg gctttttctt agtgcctctg tgcatttggg   1500

tgatgttcta tttacatggc ctgtgtaaat ctccattggg aagtcatgcc ttctaaaaag   1560

attcttattt gggggagtgg gcaaaatgtt gattattttc taatgctttg tagcaaagca   1620

tatcaattga aaagggaata tcagcacctt cctagtttgg gatttgaaaa gtggaattaa   1680

ttgcagtagg gataaagtag aagaaaccac aaattatctt gtgcctgaaa tccattaaga   1740

ggcctgatag ctttaagaat tagggtgggt tgtctgtctg gaagtgttaa gtggaatggg   1800

ctttgtcctc caggaggtgg gggaatgtgg taacattgaa tacagttgaa taaaatcgct   1860

tacaaaactc acactctcac aatgcattgt taagtatgta aaagcaataa cattgattct   1920

ctgttgtact tttttgtaac taattctgtg agagttgagc tcattttcta gttggaagaa   1980

tgtgatattt gttgtgttgg tagtttacct aatgccctta cctaattaga ttatgataaa   2040

taggtttgtc attttgcaag ttacataaac atttatcaat gaagtcatcc tttagacttg   2100

taatcgccac attgtttcat tattcagttt cctctgtaaa gggatcttga gttgttttaa   2160

tttttttttt ctgcatctga atctgcatga tttccaaacc ctgtaccatc tgaattttgc   2220

attttagcac ttgcactatt actcagcagc agtaacatgg taacacttaa aatggtactc   2280

ggggacctcc aaagactaaa ctgacaagcc ttcaaggagc ccaggggtaa gttaacttgt   2340

caacggcatg gtttaatccc ttctttacac ttgtgtaaat ttcagttact ggtcatagaa   2400

ggctttcaat gttgagtggc cttttattaa catgtttatg gtactgcata gatacgggta   2460

tttattttac cctaagaaga ttttgaagtt taaaagtact taaactattt ggcaaagatt   2520

tgtttttaaa aatctatttg gtcaatctaa atgcattcat tctaaaaaat tttttgaacc   2580

agataaataa aatttttttt tgacaccaca gtttagtgtc tggagtctta ctggaaaaac   2640

acgatttctt tttatatgtg atatacagat gctggaaagt tacctttaaa aattgagtct   2700

ctaaag                                                              2706


<210>  1412
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  1412

Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro Ala Met 
1               5                   10                  15


Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met Met Gly 
            20                  25                  30


Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn Asn Gln 
        35                  40                  45


Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly Ser Gly 
    50                  55                  60


Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly Trp Gly 
65                  70                  75                  80


Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly Phe Gly 
                85                  90                  95


Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
            100                 105


<210>  1413
<211>  1217
<212>  DNA
<213>  Homo sapiens

<400>  1413
gcatccaatg cagggtcggg cagtggtttt aatggaggct ttggctcaag catggattct     60

aagtcttctg gctggggaat gtagacagtg gggttgtggt tggttggtat agaatggtgg    120

gaattcaaat ttttctaaac tcatggtaag tatattgtaa aatacatatg tactaagaat    180

tttcaaaatt ggtttgttca gtgtggagta tattcagcag tatttttgac atttttcttt    240

agaaaaagga agagctaaag gaattttata agttttgtta catgaaaggt tgaaatattg    300

agtggttgaa agtgaactgc tgtttgcctg attggtaaac caacacacta caattgatat    360

caaaaggttt ctcctgtaat attttatccc tggacttgtc aagtgaattc tttgcatgtt    420

caaaacggaa accattgatt agaactacat tctttacccc ttgttttaat ttgaacccca    480

ccatatggat ttttttcctt aagaaaatct ccttttagga gatcatggtg tcacagtgtt    540

tggttctttt gttttgtttt ttaacacttg tctcccctca tacacaaaag tacaatatga    600

agccttcatt taatctctgc agttcatctc atttcaaatg tttatggaag aagcacttca    660

ttgaaagtag tgctgtaaat attctgccat aggaatactg tctacatgct ttctcattca    720

agaattcgtc atcacgcatc acaggccgcg tctttgacgg tgggtgtccc atttttatcc    780

gctactcttt atttcatgga gtcgtatcaa cgctatgaac gcaaggctgt gatatggaac    840

cagaaggctg tctgaacttt tgaaaccttg tgtgggattg atggtggtgc cgaggcatga    900

aaggctagta tgagcgagaa aaggagagag cgcgtgcaga gacttggtgg tgcataatgg    960

atatttttta acttggcgag atgtgtctct caatcctgtg gctttggtga gagagtgtgc   1020

agagagcaat gatagcaaat aatgtacgaa tgttttttgc attcaaagga catccacatc   1080

tgttggaaga cttttaaccc tgaatgcaaa gaattcatag cagttaattc cccttttttg   1140

acccttttga gatggaactt tcataaagtt tcttggcagt agtttatttt gcttcaaata   1200

aacttatttg aaaagtt                                                  1217


<210>  1414
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  1414

Met Tyr Glu Cys Phe Leu His Ser Lys Asp Ile His Ile Cys Trp Lys 
1               5                   10                  15


Thr Phe Asn Pro Glu Cys Lys Glu Phe Ile Ala Val Asn Ser Pro Phe 
            20                  25                  30


Leu Thr Leu Leu Arg Trp Asn Phe His Lys Val Ser Trp Gln 
        35                  40                  45


<210>  1415
<211>  2525
<212>  DNA
<213>  Homo sapiens

<400>  1415
gcatccaatg cagggtcggg cagtggtttt aatggaggct ttggctcaag catggattct     60

aagtcttctg gctggggaat gtagacagtg gggttgtggt tggttggtat agaatggtgg    120

gaattcaaat ttttctaaac tcatggtaag tatattgtaa aatacatatg tactaagaat    180

tttcaaaatt ggtttgttca gtgtggagta tattcagcag tatttttgac atttttcttt    240

agaaaaagga agagctaaag gaattttata agttttgtta catgaaaggt tgaaatattg    300

agtggttgaa agtgaactgc tgtttgcctg attggtaaac caacacacta caattgatat    360

caaaaggttt ctcctgtaat attttatccc tggacttgtc aagtgaattc tttgcatgtt    420

caaaacggaa accattgatt agaactacat tctttacccc ttgttttaat ttgaacccca    480

ccatatggat ttttttcctt aagaaaatct ccttttagga gatcatggtg tcacagtgtt    540

tggttctttt gttttgtttt ttaacacttg tctcccctca tacacaaaag tacaatatga    600

agccttcatt taatctctgc agttcatctc atttcaaatg tttatggaag aagcacttca    660

ttgaaagtag tgctgtaaat attctgccat aggaatactg tctacatgct ttctcattca    720

agaattcgtc atcacgcatc acaggccgcg tctttgacgg tgggtgtccc atttttatcc    780

gctactcttt atttcatgga gtcgtatcaa cgctatgaac gcaaggctgt gatatggaac    840

cagaaggctg tctgaacttt tgaaaccttg tgtgggattg atggtggtgc cgaggcatga    900

aaggctagta tgagcgagaa aaggagagag cgcgtgcaga gacttggtgg tgcataatgg    960

atatttttta acttggcgag atgtgtctct caatcctgtg gctttggtga gagagtgtgc   1020

agagagcaat gatagcaaat aatgtacgaa tgttttttgc attcaaagga catccacatc   1080

tgttggaaga cttttaaccc tgaatgcaaa gaattcatag cagttaattc cccttttttg   1140

acccttttga gatggaactt tcataaagtt tcttggcagt agtttatttt gcttcaaata   1200

aacttatttg aaaagttgtc tcaagtcaaa tggattcatc acctgtcatg cattgacacc   1260

tgatacccag acttaattgg tatttgttct tgcattggcc aaagtgaaaa tttttttttt   1320

tcttttgaaa tctagttttg aataagtctg ggtgaccgca cctaaaatgg taagcagtac   1380

cctccggctt tttcttagtg cctctgtgca tttgggtgat gttctattta catggcctgt   1440

gtaaatctcc attgggaagt catgccttct aaaaagattc ttatttgggg gagtgggcaa   1500

aatgttgatt attttctaat gctttgtagc aaagcatatc aattgaaaag ggaatatcag   1560

caccttccta gtttgggatt tgaaaagtgg aattaattgc agtagggata aagtagaaga   1620

aaccacaaat tatcttgtgc ctgaaatcca ttaagaggcc tgatagcttt aagaattagg   1680

gtgggttgtc tgtctggaag tgttaagtgg aatgggcttt gtcctccagg aggtggggga   1740

atgtggtaac attgaataca gttgaataaa atcgcttaca aaactcacac tctcacaatg   1800

cattgttaag tatgtaaaag caataacatt gattctctgt tgtacttttt tgtaactaat   1860

tctgtgagag ttgagctcat tttctagttg gaagaatgtg atatttgttg tgttggtagt   1920

ttacctaatg cccttaccta attagattat gataaatagg tttgtcattt tgcaagttac   1980

ataaacattt atcaatgaag tcatccttta gacttgtaat cgccacattg tttcattatt   2040

cagtttcctc tgtaaaggga tcttgagttg ttttaatttt ttttttctgc atctgaatct   2100

gcatgatttc caaaccctgt accatctgaa ttttgcattt tagcacttgc actattactc   2160

agcagcagta acatggtaac acttaaaatg gtactcgggg acctccaaag actaaactga   2220

caagccttca aggagcccag gggtaagtta acttgtcaac ggcatggttt aatcccttct   2280

ttacacttgt gtaaatttca gttactggtc atagaaggct ttcaatgttg agtggccttt   2340

tattaacatg tttatggtac tgcatagata cgggtattta ttttacccta agaagatttt   2400

gaagtttaaa agtacttaaa ctatttggca aagatttgtt tttaaaaatc tatttggtca   2460

atctaaatgc attcattcta aaaaattttt tgaaccagat aaataaaatt tttttttgac   2520

accac                                                               2525


<210>  1416
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  1416

Met Tyr Glu Cys Phe Leu His Ser Lys Asp Ile His Ile Cys Trp Lys 
1               5                   10                  15


Thr Phe Asn Pro Glu Cys Lys Glu Phe Ile Ala Val Asn Ser Pro Phe 
            20                  25                  30


Leu Thr Leu Leu Arg Trp Asn Phe His Lys Val Ser Trp Gln 
        35                  40                  45


<210>  1417
<211>  2622
<212>  DNA
<213>  Homo sapiens

<400>  1417
gcatccaatg cagggtcggg cagtggtttt aatggaggct ttggctcaag catggattct     60

aagtcttctg gctggggaat gtagacagtg gggttgtggt tggttggtat agaatggtgg    120

gaattcaaat ttttctaaac tcatggtaag tatattgtaa aatacatatg tactaagaat    180

tttcaaaatt ggtttgttca gtgtggagta tattcagcag tatttttgac atttttcttt    240

agaaaaagga agagctaaag gaattttata agttttgtta catgaaaggt tgaaatattg    300

agtggttgaa agtgaactgc tgtttgcctg attggtaaac caacacacta caattgatat    360

caaaaggttt ctcctgtaat attttatccc tggacttgtc aagtgaattc tttgcatgtt    420

caaaacggaa accattgatt agaactacat tctttacccc ttgttttaat ttgaacccca    480

ccatatggat ttttttcctt aagaaaatct ccttttagga gatcatggtg tcacagtgtt    540

tggttctttt gttttgtttt ttaacacttg tctcccctca tacacaaaag tacaatatga    600

agccttcatt taatctctgc agttcatctc atttcaaatg tttatggaag aagcacttca    660

ttgaaagtag tgctgtaaat attctgccat aggaatactg tctacatgct ttctcattca    720

agaattcgtc atcacgcatc acaggccgcg tctttgacgg tgggtgtccc atttttatcc    780

gctactcttt atttcatgga gtcgtatcaa cgctatgaac gcaaggctgt gatatggaac    840

cagaaggctg tctgaacttt tgaaaccttg tgtgggattg atggtggtgc cgaggcatga    900

aaggctagta tgagcgagaa aaggagagag cgcgtgcaga gacttggtgg tgcataatgg    960

atatttttta acttggcgag atgtgtctct caatcctgtg gctttggtga gagagtgtgc   1020

agagagcaat gatagcaaat aatgtacgaa tgttttttgc attcaaagga catccacatc   1080

tgttggaaga cttttaaccc tgaatgcaaa gaattcatag cagttaattc cccttttttg   1140

acccttttga gatggaactt tcataaagtt tcttggcagt agtttatttt gcttcaaata   1200

aacttatttg aaaagttgtc tcaagtcaaa tggattcatc acctgtcatg cattgacacc   1260

tgatacccag acttaattgg tatttgttct tgcattggcc aaagtgaaaa tttttttttt   1320

tcttttgaaa tctagttttg aataagtctg ggtgaccgca cctaaaatgg taagcagtac   1380

cctccggctt tttcttagtg cctctgtgca tttgggtgat gttctattta catggcctgt   1440

gtaaatctcc attgggaagt catgccttct aaaaagattc ttatttgggg gagtgggcaa   1500

aatgttgatt attttctaat gctttgtagc aaagcatatc aattgaaaag ggaatatcag   1560

caccttccta gtttgggatt tgaaaagtgg aattaattgc agtagggata aagtagaaga   1620

aaccacaaat tatcttgtgc ctgaaatcca ttaagaggcc tgatagcttt aagaattagg   1680

gtgggttgtc tgtctggaag tgttaagtgg aatgggcttt gtcctccagg aggtggggga   1740

atgtggtaac attgaataca gttgaataaa atcgcttaca aaactcacac tctcacaatg   1800

cattgttaag tatgtaaaag caataacatt gattctctgt tgtacttttt tgtaactaat   1860

tctgtgagag ttgagctcat tttctagttg gaagaatgtg atatttgttg tgttggtagt   1920

ttacctaatg cccttaccta attagattat gataaatagg tttgtcattt tgcaagttac   1980

ataaacattt atcaatgaag tcatccttta gacttgtaat cgccacattg tttcattatt   2040

cagtttcctc tgtaaaggga tcttgagttg ttttaatttt ttttttctgc atctgaatct   2100

gcatgatttc caaaccctgt accatctgaa ttttgcattt tagcacttgc actattactc   2160

agcagcagta acatggtaac acttaaaatg gtactcgggg acctccaaag actaaactga   2220

caagccttca aggagcccag gggtaagtta acttgtcaac ggcatggttt aatcccttct   2280

ttacacttgt gtaaatttca gttactggtc atagaaggct ttcaatgttg agtggccttt   2340

tattaacatg tttatggtac tgcatagata cgggtattta ttttacccta agaagatttt   2400

gaagtttaaa agtacttaaa ctatttggca aagatttgtt tttaaaaatc tatttggtca   2460

atctaaatgc attcattcta aaaaattttt tgaaccagat aaataaaatt tttttttgac   2520

accacagttt agtgtctgga gtcttactgg aaaaacacga tttcttttta tatgtgatat   2580

acagatgctg gaaagttacc tttaaaaatt gagtctctaa ag                      2622


<210>  1418
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  1418

Met Tyr Glu Cys Phe Leu His Ser Lys Asp Ile His Ile Cys Trp Lys 
1               5                   10                  15


Thr Phe Asn Pro Glu Cys Lys Glu Phe Ile Ala Val Asn Ser Pro Phe 
            20                  25                  30


Leu Thr Leu Leu Arg Trp Asn Phe His Lys Val Ser Trp Gln 
        35                  40                  45


<210>  1419
<211>  2454
<212>  DNA
<213>  Homo sapiens

<400>  1419
agaccaggcc aggccagctg gacgggcaca ccatgaggct gctgaccctc ctgggccttc     60

tgtgtggctc ggtggccacc cccttgggcc cgaagtggcc tgaacctgtg ttcgggcgcc    120

tggcatcccc cggctttcca ggggagtatg ccaatgacca ggagcggcgc tggaccctga    180

ctgcaccccc cggctaccgc ctgcgcctct acttcaccca cttcgacctg gagctctccc    240

acctctgcga gtacgacttc gtcaagctga gctcgggggc caaggtgctg gccacgctgt    300

gcgggcagga gagcacagac acggagcggg cccctggcaa ggacactttc tactcgctgg    360

gctccagcct ggacattacc ttccgctccg actactccaa cgagaagccg ttcacggggt    420

tcgaggcctt ctatgcagcc gaggacattg acgagtgcca ggtggccccg ggagaggcgc    480

ccacctgcga ccaccactgc cacaaccacc tgggcggttt ctactgctcc tgccgcgcag    540

gctacgtcct gcaccgtaac aagcgcacct gctcagccct gtgctccggc caggtcttca    600

cccagaggtc tggggagctc agcagccctg aatacccacg gccgtatccc aaactctcca    660

gttgcactta cagcatcagc ctggaggagg ggttcagtgt cattctggac tttgtggagt    720

ccttcgatgt ggagacacac cctgaaaccc tgtgtcccta cgactttctc aagattcaaa    780

cagacagaga agaacatggc ccattctgtg ggaagacatt gccccacagg attgaaacaa    840

aaagcaacac ggtgaccatc acctttgtca cagatgaatc aggagaccac acaggctgga    900

agatccacta cacgagcaca gcgcagcctt gcccttatcc gatggcgcca cctaatggcc    960

acgtttcacc tgtgcaagcc aaatacatcc tgaaagacag cttctccatc ttttgcgaga   1020

ctggctatga gcttctgcaa ggtcacttgc ccctgaaatc ctttactgca gtttgtcaga   1080

aagatggatc ttgggaccgg ccaatgcccg cgtgcagcat tgttgactgt ggccctcctg   1140

atgatctacc cagtggccga gtggagtaca tcacaggtcc tggagtgacc acctacaaag   1200

ctgtgattca gtacagctgt gaagagacct tctacacaat gaaagtgaat gatggtaaat   1260

atgtgtgtga ggctgatgga ttctggacga gctccaaagg agaaaaatca ctcccagtct   1320

gtgagcctgt ttgtggacta tcagcccgca caacaggagg gcgtatatat ggagggcaaa   1380

aggcaaaacc tggtgatttt ccttggcaag tcctgatatt aggtggaacc acagcagcag   1440

gtgcactttt atatgacaac tgggtcctaa cagctgctca tgccgtctat gagcaaaaac   1500

atgatgcatc cgccctggac attcgaatgg gcaccctgaa aagactatca cctcattata   1560

cacaagcctg gtctgaagct gtttttatac atgaaggtta tactcatgat gctggctttg   1620

acaatgacat agcactgatt aaattgaata acaaagttgt aatcaatagc aacatcacgc   1680

ctatttgtct gccaagaaaa gaagctgaat cctttatgag gacagatgac attggaactg   1740

catctggatg gggattaacc caaaggggtt ttcttgctag aaatctaatg tatgtcgaca   1800

taccgattgt tgaccatcaa aaatgtactg ctgcatatga aaagccaccc tatccaaggg   1860

gaagtgtaac tgctaacatg ctttgtgctg gcttagaaag tgggggcaag gacagctgca   1920

gaggtgacag cggaggggca ctggtgtttc tagatagtga aacagagagg tggtttgtgg   1980

gaggaatagt gtcctggggt tccatgaatt gtggggaagc aggtcagtat ggagtctaca   2040

caaaagttat taactatatt ccctggatcg agaacataat tagtgatttt taacttgcgt   2100

gtctgcagtc aaggattctt catttttaga aatgcctgtg aagaccttgg cagcgacgtg   2160

gctcgagaag cattcatcat tactgtggac atggcagttg ttgctccacc caaaaaaaca   2220

gactccaggt gaggctgctg tcatttctcc acttgccagt ttaattccag ccttacccat   2280

tgactcaagg ggacataaac cacgagagtg acagtcatct ttgcccaccc agtgtaatgt   2340

cactgctcaa attacatttc attaccttaa aaagccagtc tcttttcata ctggctgttg   2400

gcatttctgt aaactgcctg tccatgctct ttgtttttaa acttgttctt attg         2454


<210>  1420
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  1420

Met Arg Leu Leu Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr 
1               5                   10                  15


Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser 
            20                  25                  30


Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr 
        35                  40                  45


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60


Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80


Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95


Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser 
            100                 105                 110


Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln Val 
    130                 135                 140


Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His Leu 
145                 150                 155                 160


Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg Asn 
                165                 170                 175


Lys Arg Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gln Arg 
            180                 185                 190


Ser Gly Glu Leu Ser Ser Pro Glu Tyr Pro Arg Pro Tyr Pro Lys Leu 
        195                 200                 205


Ser Ser Cys Thr Tyr Ser Ile Ser Leu Glu Glu Gly Phe Ser Val Ile 
    210                 215                 220


Leu Asp Phe Val Glu Ser Phe Asp Val Glu Thr His Pro Glu Thr Leu 
225                 230                 235                 240


Cys Pro Tyr Asp Phe Leu Lys Ile Gln Thr Asp Arg Glu Glu His Gly 
                245                 250                 255


Pro Phe Cys Gly Lys Thr Leu Pro His Arg Ile Glu Thr Lys Ser Asn 
            260                 265                 270


Thr Val Thr Ile Thr Phe Val Thr Asp Glu Ser Gly Asp His Thr Gly 
        275                 280                 285


Trp Lys Ile His Tyr Thr Ser Thr Ala Gln Pro Cys Pro Tyr Pro Met 
    290                 295                 300


Ala Pro Pro Asn Gly His Val Ser Pro Val Gln Ala Lys Tyr Ile Leu 
305                 310                 315                 320


Lys Asp Ser Phe Ser Ile Phe Cys Glu Thr Gly Tyr Glu Leu Leu Gln 
                325                 330                 335


Gly His Leu Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp Gly 
            340                 345                 350


Ser Trp Asp Arg Pro Met Pro Ala Cys Ser Ile Val Asp Cys Gly Pro 
        355                 360                 365


Pro Asp Asp Leu Pro Ser Gly Arg Val Glu Tyr Ile Thr Gly Pro Gly 
    370                 375                 380


Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu Thr Phe 
385                 390                 395                 400


Tyr Thr Met Lys Val Asn Asp Gly Lys Tyr Val Cys Glu Ala Asp Gly 
                405                 410                 415


Phe Trp Thr Ser Ser Lys Gly Glu Lys Ser Leu Pro Val Cys Glu Pro 
            420                 425                 430


Val Cys Gly Leu Ser Ala Arg Thr Thr Gly Gly Arg Ile Tyr Gly Gly 
        435                 440                 445


Gln Lys Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Ile Leu Gly 
    450                 455                 460


Gly Thr Thr Ala Ala Gly Ala Leu Leu Tyr Asp Asn Trp Val Leu Thr 
465                 470                 475                 480


Ala Ala His Ala Val Tyr Glu Gln Lys His Asp Ala Ser Ala Leu Asp 
                485                 490                 495


Ile Arg Met Gly Thr Leu Lys Arg Leu Ser Pro His Tyr Thr Gln Ala 
            500                 505                 510


Trp Ser Glu Ala Val Phe Ile His Glu Gly Tyr Thr His Asp Ala Gly 
        515                 520                 525


Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu Asn Asn Lys Val Val Ile 
    530                 535                 540


Asn Ser Asn Ile Thr Pro Ile Cys Leu Pro Arg Lys Glu Ala Glu Ser 
545                 550                 555                 560


Phe Met Arg Thr Asp Asp Ile Gly Thr Ala Ser Gly Trp Gly Leu Thr 
                565                 570                 575


Gln Arg Gly Phe Leu Ala Arg Asn Leu Met Tyr Val Asp Ile Pro Ile 
            580                 585                 590


Val Asp His Gln Lys Cys Thr Ala Ala Tyr Glu Lys Pro Pro Tyr Pro 
        595                 600                 605


Arg Gly Ser Val Thr Ala Asn Met Leu Cys Ala Gly Leu Glu Ser Gly 
    610                 615                 620


Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe Leu 
625                 630                 635                 640


Asp Ser Glu Thr Glu Arg Trp Phe Val Gly Gly Ile Val Ser Trp Gly 
                645                 650                 655


Ser Met Asn Cys Gly Glu Ala Gly Gln Tyr Gly Val Tyr Thr Lys Val 
            660                 665                 670


Ile Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile Ser Asp Phe 
        675                 680                 685


<210>  1421
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  1421
gtaaaatggg tatttatgta atcctaggaa agcaggaact aaagtcagta tcaggatttg     60

caaaattact tttacctttg aacatacaaa tgttttagaa attagaatgt tgcagttgtg    120

gctaggaccc tgtggattcc aaaattttat ttttggtcta gttgattctt ccaaactaag    180

ttttattgta tctttattgc aaattaaata cgcccattaa tgtagcatat atgtttgctg    240

ttgtggtagt gtacttgcat taatacctac agacgttgtg ttagccaaat acaggtttaa    300

aaaaactaat ttgagccaaa taacacaagg gtaattaata tattactatc tttctgggtt    360

tgttttttt                                                            369


<210>  1422
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  1422

Met Leu Gln Leu Trp Leu Gly Pro Cys Gly Phe Gln Asn Phe Ile Phe 
1               5                   10                  15


Gly Leu Val Asp Ser Ser Lys Leu Ser Phe Ile Val Ser Leu Leu Gln 
            20                  25                  30


Ile Lys Tyr Ala His 
        35


<210>  1423
<211>  443
<212>  DNA
<213>  Homo sapiens

<400>  1423
aaggctgggg ccttcgagta caagtgtggg aggcagagtg gggaggggca ccccaatcca     60

tggcctgggt tggcctcatt ggctgtccct gaaatgctga ggaggtgggt tacttccctc    120

cggcccaggc cagacccagg cagctgctcc ccagctttca tgagcttctt tctcagattc    180

aaacagacag agaagaacat ggcccattct gtgggaagac attgccccac aggattgaaa    240

caaaaagcaa cacggtgacc atcacctttg tcacagatga atcaggagac cacacaggct    300

ggaagatcca ctacacgagc acagcgcagc cttgccctta tccgatggcg ccacctaatg    360

gccacgtttc acctgtgcaa gccaaataca tcctgaaaga cagcttctcc atcttttgcg    420

agactggcta tgagcttctg caa                                            443


<210>  1424
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  1424

Met Asn Gln Glu Thr Thr Gln Ala Gly Arg Ser Thr Thr Arg Ala Gln 
1               5                   10                  15


Arg Ser Leu Ala Leu Ile Arg Trp Arg His Leu Met Ala Thr Phe His 
            20                  25                  30


Leu Cys Lys Pro Asn Thr Ser 
        35


<210>  1425
<211>  732
<212>  DNA
<213>  Homo sapiens

<400>  1425
agaccaggcc aggccagctg gacgggcaca ccatgaggct gctgaccctc ctgggccttc     60

tgtgtggctc ggtggccacc cccttgggcc cgaagtggcc tgaacctgtg ttcgggcgcc    120

tggcatcccc cggctttcca ggggagtatg ccaatgacca ggagcggcgc tggaccctga    180

ctgcaccccc cggctaccgc ctgcgcctct acttcaccca cttcgacctg gagctctccc    240

acctctgcga gtacgacttc gtcaagctga gctcgggggc caaggtgctg gccacgctgt    300

gcgggcagga gagcacagac acggagcggg cccctggcaa ggacactttc tactcgctgg    360

gctccagcct ggacattacc ttccgctccg actactccaa cgagaagccg ttcacggggt    420

tcgaggcctt ctatgcagcc gaggacattg acgagtgcca ggtggccccg ggagaggcgc    480

ccacctgcga ccaccactgc cacaaccacc tgggcggttt ctactgctcc tgccgcgcag    540

gctacgtcct gcaccgtaac aagcgcacct gctcagagca gagcctctag cctcccctgg    600

agctccggcc tgcccagcag gtcagaagcc agagccagcc tgctggcctc agctccgggt    660

tgggctgaga tggctgtgcc ccaactccca ttcacccacc atggacccaa taataaacct    720

ggccccaccc ca                                                        732


<210>  1426
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  1426

Met Arg Leu Leu Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr 
1               5                   10                  15


Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser 
            20                  25                  30


Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr 
        35                  40                  45


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60


Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80


Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95


Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser 
            100                 105                 110


Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln Val 
    130                 135                 140


Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His Leu 
145                 150                 155                 160


Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg Asn 
                165                 170                 175


Lys Arg Thr Cys Ser Glu Gln Ser Leu 
            180                 185


<210>  1427
<211>  1173
<212>  DNA
<213>  Homo sapiens

<400>  1427
gccagctgga cgggcacacc atgaggctgc tgaccctcct gggccttctg tgtggctcgg     60

tggccacccc cttgggcccg aagtggcctg aacctgtgtt cgggcgcctg gcatcccccg    120

gctttccagg ggagtatgcc aatgaccagg agcggcgctg gaccctgact gcaccccccg    180

gctaccgcct gcgcctctac ttcacccact tcgacctgga gctctcccac ctctgcgagt    240

acgacttcgt caagctgagc tcgggggcca aggtgctggc cacgctgtgc gggcaggaga    300

gcacagacac ggagcgggcc cctggcaagg acactttcta ctcgctgggc tccagcctgg    360

acattacctt ccgctccgac tactccaacg agaagccgtt cacggggttc gaggccttct    420

atgcagccga ggacattgac gagtgccagg tggccccggg agaggcgccc acctgcgacc    480

accactgcca caaccacctg ggcggtttct actgctcctg ccgcgcaggc tacgtcctgc    540

accgtaacaa gcgcacctgc tcaggtgagg gaggctgcct gggccccaac gcaccctctc    600

ctgggatacc cggggctcct cagggccatt gctgctctgc ccaggggtgc ggagggcctg    660

ggccctggac actgggtgct tctaggccct gctgcctcca gctccccttc tcagccctgc    720

ttcccctctc agcagccagg ctcatcagtg ccaccctgcc ctagcgactg agactaattc    780

taacatccca ctgtgtacct ggttccacct gggctctggg aacccctcat gtagccacgg    840

gagagtcggg ggtatctagc cctcgttcct tgggacctgg ttccctggtt ccctgcactg    900

tgggacgggc cagtgctctg gggcgtgggc agccccacct gctggcgctg accctgcctc    960

ccccgactcg gtttctccct ctcggtgtct ctccttgcct ctctgatctc tcttccagag   1020

cagagcctct agcctcccct ggagctccgg cctgcccagc aggtcagaag ccagagccag   1080

cctgctggcc tcagctccgg gttgggctga gatggctgtg ccccaactcc cattcaccca   1140

ccatggaccc aataataaac ctggccccac ccc                                1173


<210>  1428
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  1428

Met Arg Leu Leu Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr 
1               5                   10                  15


Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser 
            20                  25                  30


Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr 
        35                  40                  45


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60


Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80


Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95


Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser 
            100                 105                 110


Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln Val 
    130                 135                 140


Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His Leu 
145                 150                 155                 160


Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg Asn 
                165                 170                 175


Lys Arg Thr Cys Ser Gly Glu Gly Gly Cys Leu Gly Pro Asn Ala Pro 
            180                 185                 190


Ser Pro Gly Ile Pro Gly Ala Pro Gln Gly His Cys Cys Ser Ala Gln 
        195                 200                 205


Gly Cys Gly Gly Pro Gly Pro Trp Thr Leu Gly Ala Ser Arg Pro Cys 
    210                 215                 220


Cys Leu Gln Leu Pro Phe Ser Ala Leu Leu Pro Leu Ser Ala Ala Arg 
225                 230                 235                 240


Leu Ile Ser Ala Thr Leu Pro 
                245


<210>  1429
<211>  2190
<212>  DNA
<213>  Homo sapiens

<400>  1429
ggccagctgg acgggcacac catgaggctg ctgaccctcc tgggccttct gtgtggctcg     60

gtggccaccc ccttgggccc gaagtggcct gaacctgtgt tcgggcgcct ggcatccccc    120

ggctttccag gggagtatgc caatgaccag gagcggcgct ggaccctgac tgcacccccc    180

ggctaccgcc tgcgcctcta cttcacccac ttcgacctgg agctctccca cctctgcgag    240

tacgacttcg tcaagctgag ctcgggggcc aaggtgctgg ccacgctgtg cgggcaggag    300

agcacagaca cggagcgggc ccctggcaag gacactttct actcgctggg ctccagcctg    360

gacattacct tccgctccga ctactccaac gagaagccgt tcacggggtt cgaggccttc    420

tatgcagccg agggtgagcc aagaggggtc ctgcaacatc tcagtctgcg cagctggctg    480

tgggggtaac tctgtcttag gccaggcagc cctgccttca gtttccccac ctttcccagg    540

gcaggggaga ggcctctggc ctgacatcat ccacaatgca aagaccaaaa cagccgtgac    600

ctccattcac atgggctgag tgccaactct gagccaggga tctgaggaca gcatcgcctc    660

aagtgacgca gggactggcc gggcgcagca gctcacgcct gtaattccag cactttggga    720

ggccgaggct ggctgatcat ttgaggtcag gagttcaagg ccagccaggg caacacggtg    780

aaactctatc tccactaaaa ctacaaaaat tagctgggcg tggtggtgcg cacctggaat    840

cccagctact agggaggctg aggcaggaga attgcttgaa cctgcgaggt ggaggctgca    900

gtgaacagag attgcaccac tacactccag cctgggcgac agagctagac tccgtctcaa    960

aaaacaaaaa acaaaaacga cgcaggggcc gagggcccca tttacagctg acaaagtggg   1020

gccctgccag cgggagcgct gccaggatgt ttgatttcag atcccagtcc ctgcagagac   1080

caactgtgtg acctctggca agtggctcaa tttctctgct ccttaggaag ctgctgcaag   1140

ggttcagcgc tgtagccccg ccccctgggt ttgattgact cccctcatta gctgggtgac   1200

ctcgggccgg acactgaaac tcccactggt ttaacagagg tgatgtttgc atctttctcc   1260

cagcgctgct gggagcttgc agcgacccta ggcctgtaag gtgattggcc cggcaccagt   1320

cccgcaccct agacaggacg aggcctcctc tgaggtccac tctgaggtca tggatctcct   1380

gggaggagtc caggctggat cccgcctctt tccctcctga cggcctgcct ggccctgcct   1440

ctcccccaga cattgacgag tgccaggtgg ccccgggaga ggcgcccacc tgcgaccacc   1500

actgccacaa ccacctgggc ggtttctact gctcctgccg cgcaggctac gtcctgcacc   1560

gtaacaagcg cacctgctca ggtgagggag gctgcctggg ccccaacgca ccctctcctg   1620

ggatacccgg ggctcctcag ggccattgct gctctgccca ggggtgcgga gggcctgggc   1680

cctggacact gggtgcttct aggccctgct gcctccagct ccccttctca gccctgcttc   1740

ccctctcagc agccaggctc atcagtgcca ccctgcccta gcgactgaga ctaattctaa   1800

catcccactg tgtacctggt tccacctggg ctctgggaac ccctcatgta gccacgggag   1860

agtcgggggt atctagccct cgttccttgg gacctggttc cctggttccc tgcactgtgg   1920

gacgggccag tgctctgggg cgtgggcagc cccacctgct ggcgctgacc ctgcctcccc   1980

cgactcggtt tctccctctc ggtgtctctc cttgcctctc tgatctctct tccagagcag   2040

agcctctagc ctcccctgga gctccggcct gcccagcagg tcagaagcca gagccagcct   2100

gctggcctca gctccgggtt gggctgagat ggctgtgccc caactcccat tcacccacca   2160

tggacccaat aataaacctg gccccacccc                                    2190


<210>  1430
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  1430

Met Arg Leu Leu Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr 
1               5                   10                  15


Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser 
            20                  25                  30


Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr 
        35                  40                  45


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60


Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80


Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95


Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser 
            100                 105                 110


Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Gly Glu Pro Arg Gly Val Leu 
    130                 135                 140


Gln His Leu Ser Leu Arg Ser Trp Leu Trp Gly 
145                 150                 155


<210>  1431
<211>  546
<212>  DNA
<213>  Homo sapiens

<400>  1431
cagaggttgc agtgagctga gatgacgcca ctgcactcca gcgtggcaac agtgagactc     60

cgtctcaaaa aaaaaaaaaa aaaagtgccc cccctgatgt gcccctggcc cggtccccag    120

agcacgaact tccaggagcc ggtgcagccg ctgacacagc agcaggtggc gcagatgcag    180

ctgaagtact acaactccga cgtgcaccgc gccgcctttg tgctgcccga gtttgcccgc    240

aaggccctga atgatgtgag ctgagcccag gcgccaccac tgatgccacc caggacctcg    300

gaccttggag cctgcggggt gcctcggccc ctccagcccc gggccggacc tcctgctggc    360

tctcgcccac caaccaagtg ttacaagccc cagaatgctg cccggcctgc cctgctgggc    420

ggactgtctg tgtgtctgtc tctctggcgt tccacctcca agcctatacc agctgtgtac    480

agcgccatct ctctgccttc tgttgcccct cactcaccaa acacgtgtat ttatagcaaa    540

gattgg                                                               546


<210>  1432
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  1432

Met Thr Pro Leu His Ser Ser Val Ala Thr Val Arg Leu Arg Leu Lys 
1               5                   10                  15


Lys Lys Lys Lys Lys Val Pro Pro Leu Met Cys Pro Trp Pro Gly Pro 
            20                  25                  30


Gln Ser Thr Asn Phe Gln Glu Pro Val Gln Pro Leu Thr Gln Gln Gln 
        35                  40                  45


Val Ala Gln Met Gln Leu Lys Tyr Tyr Asn Ser Asp Val His Arg Ala 
    50                  55                  60


Ala Phe Val Leu Pro Glu Phe Ala Arg Lys Ala Leu Asn Asp Val Ser 
65                  70                  75                  80


<210>  1433
<211>  1280
<212>  DNA
<213>  Homo sapiens

<400>  1433
gcgcgggcgg cgggcggagc tggtcccgtt gtgctgcggc gccgcgcggc ctgcagtccc     60

gggcccgcgc cccgcgccgc ccgcccgccc gccatggagc ccggccccga cggccccgcc    120

gcctccggcc ccgccgccat ccgcgagggc tggttccgcg agacctgcag cctgtggccc    180

ggccaggccc tgtcactgca ggtggagcag ctgctccacc accggcgctc gcgctaccag    240

gacatcctcg tcttccgcag taagacctat ggcaacgtgc tggtgttgga cggtgtcatc    300

cagtgcacgg agagagacga gttctcctac caggagatga tcgccaacct gcctctctgc    360

agccacccca acccgcgaaa ggtgctgatc atcgggggcg gagatggagg tgtcctgcgg    420

gaggtggtga agcacccctc cgtggagtcc gtggtccagt gtgagatcga cgaggatgtc    480

atccaagtct ccaagaagtt cctgccaggc atggccattg gctactctag ctcgaagctg    540

accctacatg tgggtgacgg ttttgagttc atgaaacaga atcaggatgc cttcgacgtg    600

atcatcactg actcctcaga ccccatgggc cccgccgaaa gtctcttcaa ggagtcctat    660

taccagctca tgaagacagc cctcaaggaa gatggtgtcc tctgctgcca gggcgagtgc    720

cagtggctgc acctggacct catcaaggag atgcggcagt tctgccagtc cctgttcccc    780

gtggtggcct atgcctactg caccatcccc acctacccca gcggccagat cggcttcatg    840

ctgtgcagca agaacccgag cacgaacttc caggagccgg tgcagccgct gacacagcag    900

caggtggcgc agatgcagct gaagtactac aactccgacg tgcaccgcgc cgcctttgtg    960

ctgcccgagt ttgcccgcaa ggccctgaat gatgtgagct gagcccaggc gccaccactg   1020

atgccaccca ggacctcgga ccttggagcc tgcggggtgc ctcggcccct ccagccccgg   1080

gccggacctc ctgctggctc tcgcccacca accaagtgtt acaagcccca gaatgctgcc   1140

cggcctgccc tgctgggcgg actgtctgtg tgtctgtctc tctggcgttc cacctccaag   1200

cctataccag ctgtgtacag cgccatctct ctgccttctg ttgcccctca ctcaccaaac   1260

acgtgtattt atagcaaaga                                               1280


<210>  1434
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  1434

Met Glu Pro Gly Pro Asp Gly Pro Ala Ala Ser Gly Pro Ala Ala Ile 
1               5                   10                  15


Arg Glu Gly Trp Phe Arg Glu Thr Cys Ser Leu Trp Pro Gly Gln Ala 
            20                  25                  30


Leu Ser Leu Gln Val Glu Gln Leu Leu His His Arg Arg Ser Arg Tyr 
        35                  40                  45


Gln Asp Ile Leu Val Phe Arg Ser Lys Thr Tyr Gly Asn Val Leu Val 
    50                  55                  60


Leu Asp Gly Val Ile Gln Cys Thr Glu Arg Asp Glu Phe Ser Tyr Gln 
65                  70                  75                  80


Glu Met Ile Ala Asn Leu Pro Leu Cys Ser His Pro Asn Pro Arg Lys 
                85                  90                  95


Val Leu Ile Ile Gly Gly Gly Asp Gly Gly Val Leu Arg Glu Val Val 
            100                 105                 110


Lys His Pro Ser Val Glu Ser Val Val Gln Cys Glu Ile Asp Glu Asp 
        115                 120                 125


Val Ile Gln Val Ser Lys Lys Phe Leu Pro Gly Met Ala Ile Gly Tyr 
    130                 135                 140


Ser Ser Ser Lys Leu Thr Leu His Val Gly Asp Gly Phe Glu Phe Met 
145                 150                 155                 160


Lys Gln Asn Gln Asp Ala Phe Asp Val Ile Ile Thr Asp Ser Ser Asp 
                165                 170                 175


Pro Met Gly Pro Ala Glu Ser Leu Phe Lys Glu Ser Tyr Tyr Gln Leu 
            180                 185                 190


Met Lys Thr Ala Leu Lys Glu Asp Gly Val Leu Cys Cys Gln Gly Glu 
        195                 200                 205


Cys Gln Trp Leu His Leu Asp Leu Ile Lys Glu Met Arg Gln Phe Cys 
    210                 215                 220


Gln Ser Leu Phe Pro Val Val Ala Tyr Ala Tyr Cys Thr Ile Pro Thr 
225                 230                 235                 240


Tyr Pro Ser Gly Gln Ile Gly Phe Met Leu Cys Ser Lys Asn Pro Ser 
                245                 250                 255


Thr Asn Phe Gln Glu Pro Val Gln Pro Leu Thr Gln Gln Gln Val Ala 
            260                 265                 270


Gln Met Gln Leu Lys Tyr Tyr Asn Ser Asp Val His Arg Ala Ala Phe 
        275                 280                 285


Val Leu Pro Glu Phe Ala Arg Lys Ala Leu Asn Asp Val Ser 
    290                 295                 300


<210>  1435
<211>  536
<212>  DNA
<213>  Homo sapiens

<400>  1435
cagcggccag atcggcttca tgctgtgcag caagaacccg agcacgaact tccaggagcc     60

ggtgcagccg ctgacacagc agcaggtggc gcagatgcag ctgaagtact acaactccga    120

cgtgcaccgc gccgcctttg tgctgcccga gtttgcccgc aaggtgggtg gcctgcgggg    180

ctgggtggtg ggacccaggg acccagagcg ccctcctgac tggcctcatg tccctccagg    240

ccctgaatga tgtgagctga gcccaggcgc caccactgat gccacccagg acctcggacc    300

ttggagcctg cggggtgcct cggcccctcc agccccgggc cggacctcct gctggctctc    360

gcccaccaac caagtgttac aagccccaga atgctgcccg gcctgccctg ctgggcggac    420

tgtctgtgtg tctgtctctc tggcgttcca cctccaagcc tataccagct gtgtacagcg    480

ccatctctct gccttctgtt gcccctcact caccaaacac gtgtatttat agcaaa        536


<210>  1436
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  1436

Met Leu Cys Ser Lys Asn Pro Ser Thr Asn Phe Gln Glu Pro Val Gln 
1               5                   10                  15


Pro Leu Thr Gln Gln Gln Val Ala Gln Met Gln Leu Lys Tyr Tyr Asn 
            20                  25                  30


Ser Asp Val His Arg Ala Ala Phe Val Leu Pro Glu Phe Ala Arg Lys 
        35                  40                  45


Val Gly Gly Leu Arg Gly Trp Val Val Gly Pro Arg Asp Pro Glu Arg 
    50                  55                  60


Pro Pro Asp Trp Pro His Val Pro Pro Gly Pro Glu 
65                  70                  75


<210>  1437
<211>  2996
<212>  DNA
<213>  Homo sapiens

<400>  1437
gatctcggct cactgtaacc tccacctccc gggctcaagc ctcagcctcc cgagtagctg     60

ggattacagg gtttcatcct gtcaccccgg ctggagtgca gtggagcctc cacctcctcg    120

gctcaagcaa ccatcccacc tcagcctccc gagcagctgg gactacagat gcgcaccacc    180

actcccggct ccccacacta taatcagacg ccccgcccgc cgcttcgacc tggcgcatgc    240

gtggtgcgca cgcgtcccgt ctcctcggcc gacaagctct cgcgagacga gccgtgcagg    300

ctgaaaaaat ggcgccaccc agtacccggg agcccagggt cctgtcggcg accagcgcaa    360

ccaaatccga cggagagatg gtgctgccag gcttcccgga cgccgacagc tttgtgaagt    420

ttgctcttgg gtccgtggtg gcagtcacca aggcatctgg gggcctacca cagtttggcg    480

atgagtatga tttttaccga agttttcctg gcttccaagc attttgcgaa acacagggag    540

acaggttgct tcagtgcatg agcagagtaa tgcagtacca tgggtgtcgc agcaacatta    600

aggatcgaag taaagtgact gagctggaag acaagtttga tttactagtt gatgccaatg    660

atgtaattct ggagagagtg ggtattttac tggatgaagc ctcaggtgta aacaagaatc    720

aacagcctgt cctccctgcc ggcttgcagg tccccaaaac ggtagtgtcc agctggaacc    780

gtaaggcagc agaatatggc aaaaaagcaa aatctgaaac tttccggctg cttcatgcaa    840

aaaatatcat ccgacctcag ctcaagtttc gagagaagat tgacaattcc aacacaccat    900

ttcttcctaa aatcttcatc aaacccaatg ctcagaaacc tctccctcaa gctctctcta    960

aggaaaggcg ggaacgccca caggatcgtc ctgaggactt ggacgtcccc cctgcactgg   1020

ctgatttcat ccatcagcag agaacccagc aggttgagca agacatgttt gcacatcctt   1080

atcaatatga actaaatcac tttaccccag cagatgcagt gcttcaaaag ccacaacccc   1140

agttatacag acctatagaa gagacaccat gccatttcat atcctccctg gatgaactcg   1200

tggaactcaa cgaaaagctc ttgaattgtc aggaatttgc agttgacttg gagcaccact   1260

cttacaggag cttcctggga ctgacctgcc tgatgcaaat ttctactcgg acggaagact   1320

tcatcattga caccctcgag cttcgaagtg acatgtacat tctcaatgag agcctcacag   1380

acccagccat cgttaaggtc tttcatggtg ctgattcaga catagaatgg ctacagaaag   1440

actttgggtt gtatgtagta aacatgtttg atactcatca ggcagcacgc cttcttaacc   1500

tgggcaggca ctcactcgat catctcctga aactctactg caacgtggac tcaaacaagc   1560

aatatcagct ggctgattgg agaatacgcc ctctgcccga ggagatgctc agctacgccc   1620

gggatgacac ccattacctg ctatatatct atgacaaaat gaggctggag atgtgggagc   1680

gcggcaacgg gcagccggtg cagctgcagg tggtgtggca acggagcagg gacatctgcc   1740

tcaagaaatt catcaaacct atcttcacgg atgagtccta ccttgaactc tataggaagc   1800

agaagaagca ccttaacaca cagcagttga cagcctttca gctgctgttt gcctggaggg   1860

ataaaacagc tcgcagggaa gatgaaagtt acggatatgt actgccaaac cacatgatgc   1920

tgaaaatagc tgaagaactg cctaaggaac ctcagggcat catagcttgc tgcaacccag   1980

taccgcccct tgtgcggcag cagatcaacg aaatgcacct tttaatccag caggcccgag   2040

agatgcccct gctcaagtct gaagttgcag ccggagtgaa gaagagcgga ccgctgccca   2100

gtgctgagag attggagaat gttctctttg gacctcacga ctgctcccat gcccctccgg   2160

atggctatcc aatcatccca accagtggat ctgtgccagt tcagaagcag gcgagcctct   2220

tccctgatga aaaagaagat aacttgctgg gtaccacatg cctgattgcc acagctgtca   2280

tcacgttatt taatgaacct agtgctgaag acagtaaaaa gggtccattg acagttgcac   2340

agaaaaaagc ccagaacatc atggagtcct ttgaaaatcc atttaggatg atcagcaacc   2400

gctggaagct ggcccaggta caagtacaaa aagactctaa agaagctgtc aagaagaagg   2460

cagctgagca aacagctgcc cgggaacagg caaaggaggc gtgcaaagct gcagcagaac   2520

aggccatctc cgtccgacag caggtcgtgc tagaaaatgc tgcaaagaag agagagcgag   2580

caacaagcga cccaaggacc acagaacaga aacaagagaa gaaacgactc aaaatttcca   2640

agaagccaaa ggacccagag ccaccagaaa aagagtttac gccttacgac tacagccagt   2700

cagacttcaa ggcttttgct ggaaacagca aatccaaagt ttcttctcag tttgatccaa   2760

ataaacagac cccgtctggc aagaaatgca ttgcagccaa aaaaattaaa cagtcggtgg   2820

gaaacaaaag catgtccttt ccaactggaa agtcagacag aggcttcagg tacaactggc   2880

cacagagata gtcctggaag acacgtggcg cctgtggacc ggaagcacca aatgctggtg   2940

ctgcttttgt acatacatat ttttaaacca ttaaaattct tcctgaagaa agctga       2996


<210>  1438
<211>  884
<212>  PRT
<213>  Homo sapiens

<400>  1438

Met Arg Gly Ala His Ala Ser Arg Leu Leu Gly Arg Gln Ala Leu Ala 
1               5                   10                  15


Arg Arg Ala Val Gln Ala Glu Lys Met Ala Pro Pro Ser Thr Arg Glu 
            20                  25                  30


Pro Arg Val Leu Ser Ala Thr Ser Ala Thr Lys Ser Asp Gly Glu Met 
        35                  40                  45


Val Leu Pro Gly Phe Pro Asp Ala Asp Ser Phe Val Lys Phe Ala Leu 
    50                  55                  60


Gly Ser Val Val Ala Val Thr Lys Ala Ser Gly Gly Leu Pro Gln Phe 
65                  70                  75                  80


Gly Asp Glu Tyr Asp Phe Tyr Arg Ser Phe Pro Gly Phe Gln Ala Phe 
                85                  90                  95


Cys Glu Thr Gln Gly Asp Arg Leu Leu Gln Cys Met Ser Arg Val Met 
            100                 105                 110


Gln Tyr His Gly Cys Arg Ser Asn Ile Lys Asp Arg Ser Lys Val Thr 
        115                 120                 125


Glu Leu Glu Asp Lys Phe Asp Leu Leu Val Asp Ala Asn Asp Val Ile 
    130                 135                 140


Leu Glu Arg Val Gly Ile Leu Leu Asp Glu Ala Ser Gly Val Asn Lys 
145                 150                 155                 160


Asn Gln Gln Pro Val Leu Pro Ala Gly Leu Gln Val Pro Lys Thr Val 
                165                 170                 175


Val Ser Ser Trp Asn Arg Lys Ala Ala Glu Tyr Gly Lys Lys Ala Lys 
            180                 185                 190


Ser Glu Thr Phe Arg Leu Leu His Ala Lys Asn Ile Ile Arg Pro Gln 
        195                 200                 205


Leu Lys Phe Arg Glu Lys Ile Asp Asn Ser Asn Thr Pro Phe Leu Pro 
    210                 215                 220


Lys Ile Phe Ile Lys Pro Asn Ala Gln Lys Pro Leu Pro Gln Ala Leu 
225                 230                 235                 240


Ser Lys Glu Arg Arg Glu Arg Pro Gln Asp Arg Pro Glu Asp Leu Asp 
                245                 250                 255


Val Pro Pro Ala Leu Ala Asp Phe Ile His Gln Gln Arg Thr Gln Gln 
            260                 265                 270


Val Glu Gln Asp Met Phe Ala His Pro Tyr Gln Tyr Glu Leu Asn His 
        275                 280                 285


Phe Thr Pro Ala Asp Ala Val Leu Gln Lys Pro Gln Pro Gln Leu Tyr 
    290                 295                 300


Arg Pro Ile Glu Glu Thr Pro Cys His Phe Ile Ser Ser Leu Asp Glu 
305                 310                 315                 320


Leu Val Glu Leu Asn Glu Lys Leu Leu Asn Cys Gln Glu Phe Ala Val 
                325                 330                 335


Asp Leu Glu His His Ser Tyr Arg Ser Phe Leu Gly Leu Thr Cys Leu 
            340                 345                 350


Met Gln Ile Ser Thr Arg Thr Glu Asp Phe Ile Ile Asp Thr Leu Glu 
        355                 360                 365


Leu Arg Ser Asp Met Tyr Ile Leu Asn Glu Ser Leu Thr Asp Pro Ala 
    370                 375                 380


Ile Val Lys Val Phe His Gly Ala Asp Ser Asp Ile Glu Trp Leu Gln 
385                 390                 395                 400


Lys Asp Phe Gly Leu Tyr Val Val Asn Met Phe Asp Thr His Gln Ala 
                405                 410                 415


Ala Arg Leu Leu Asn Leu Gly Arg His Ser Leu Asp His Leu Leu Lys 
            420                 425                 430


Leu Tyr Cys Asn Val Asp Ser Asn Lys Gln Tyr Gln Leu Ala Asp Trp 
        435                 440                 445


Arg Ile Arg Pro Leu Pro Glu Glu Met Leu Ser Tyr Ala Arg Asp Asp 
    450                 455                 460


Thr His Tyr Leu Leu Tyr Ile Tyr Asp Lys Met Arg Leu Glu Met Trp 
465                 470                 475                 480


Glu Arg Gly Asn Gly Gln Pro Val Gln Leu Gln Val Val Trp Gln Arg 
                485                 490                 495


Ser Arg Asp Ile Cys Leu Lys Lys Phe Ile Lys Pro Ile Phe Thr Asp 
            500                 505                 510


Glu Ser Tyr Leu Glu Leu Tyr Arg Lys Gln Lys Lys His Leu Asn Thr 
        515                 520                 525


Gln Gln Leu Thr Ala Phe Gln Leu Leu Phe Ala Trp Arg Asp Lys Thr 
    530                 535                 540


Ala Arg Arg Glu Asp Glu Ser Tyr Gly Tyr Val Leu Pro Asn His Met 
545                 550                 555                 560


Met Leu Lys Ile Ala Glu Glu Leu Pro Lys Glu Pro Gln Gly Ile Ile 
                565                 570                 575


Ala Cys Cys Asn Pro Val Pro Pro Leu Val Arg Gln Gln Ile Asn Glu 
            580                 585                 590


Met His Leu Leu Ile Gln Gln Ala Arg Glu Met Pro Leu Leu Lys Ser 
        595                 600                 605


Glu Val Ala Ala Gly Val Lys Lys Ser Gly Pro Leu Pro Ser Ala Glu 
    610                 615                 620


Arg Leu Glu Asn Val Leu Phe Gly Pro His Asp Cys Ser His Ala Pro 
625                 630                 635                 640


Pro Asp Gly Tyr Pro Ile Ile Pro Thr Ser Gly Ser Val Pro Val Gln 
                645                 650                 655


Lys Gln Ala Ser Leu Phe Pro Asp Glu Lys Glu Asp Asn Leu Leu Gly 
            660                 665                 670


Thr Thr Cys Leu Ile Ala Thr Ala Val Ile Thr Leu Phe Asn Glu Pro 
        675                 680                 685


Ser Ala Glu Asp Ser Lys Lys Gly Pro Leu Thr Val Ala Gln Lys Lys 
    690                 695                 700


Ala Gln Asn Ile Met Glu Ser Phe Glu Asn Pro Phe Arg Met Ile Ser 
705                 710                 715                 720


Asn Arg Trp Lys Leu Ala Gln Val Gln Val Gln Lys Asp Ser Lys Glu 
                725                 730                 735


Ala Val Lys Lys Lys Ala Ala Glu Gln Thr Ala Ala Arg Glu Gln Ala 
            740                 745                 750


Lys Glu Ala Cys Lys Ala Ala Ala Glu Gln Ala Ile Ser Val Arg Gln 
        755                 760                 765


Gln Val Val Leu Glu Asn Ala Ala Lys Lys Arg Glu Arg Ala Thr Ser 
    770                 775                 780


Asp Pro Arg Thr Thr Glu Gln Lys Gln Glu Lys Lys Arg Leu Lys Ile 
785                 790                 795                 800


Ser Lys Lys Pro Lys Asp Pro Glu Pro Pro Glu Lys Glu Phe Thr Pro 
                805                 810                 815


Tyr Asp Tyr Ser Gln Ser Asp Phe Lys Ala Phe Ala Gly Asn Ser Lys 
            820                 825                 830


Ser Lys Val Ser Ser Gln Phe Asp Pro Asn Lys Gln Thr Pro Ser Gly 
        835                 840                 845


Lys Lys Cys Ile Ala Ala Lys Lys Ile Lys Gln Ser Val Gly Asn Lys 
    850                 855                 860


Ser Met Ser Phe Pro Thr Gly Lys Ser Asp Arg Gly Phe Arg Tyr Asn 
865                 870                 875                 880


Trp Pro Gln Arg 



<210>  1439
<211>  3071
<212>  DNA
<213>  Homo sapiens

<400>  1439
gatctcggct cactgtaacc tccacctccc gggctcaagc ctcagcctcc cgagtagctg     60

ggattacagg gtttcatcct gtcaccccgg ctggagtgca gtggagcctc cacctcctcg    120

gctcaagcaa ccatcccacc tcagcctccc gagcagctgg gactacagat gcgcaccacc    180

actcccggct ccccacacta taatcagacg ccccgcccgc cgcttcgacc tggcgcatgc    240

gtggtgcgca cgcgtcccgt ctcctcggcc gacaagctct cgcgagacga gccgtgcagg    300

ctgaaaaaat ggcgccaccc agtacccggg agcccagggt cctgtcggcg accagcgcaa    360

ccaaatccga cggagagatg gtgctgccag gcttcccgga cgccgacagc tttgtgaagt    420

ttgctcttgg gtccgtggtg gcagtcacca aggcatctgg gggcctacca cagtttggcg    480

atgagtatga tttttaccga agttttcctg gcttccaagc attttgcgaa acacagggag    540

acaggttgct tcagtgcatg agcagagtaa tgcagtacca tgggtgtcgc agcaacatta    600

aggatcgaag taaagtgact gagctggaag acaagtttga tttactagtt gatgccaatg    660

atgtaattct ggagagagtg ggtattttac tggatgaagc ctcaggtgta aacaagaatc    720

aacagcctgt cctccctgcc ggcttgcagg tccccaaaac ggtagtgtcc agctggaacc    780

gtaaggcagc agaatatggc aaaaaagcaa aatctgaaac tttccggctg cttcatgcaa    840

aaaatatcat ccgacctcag ctcaagtttc gagagaagat tgacaattcc aacacaccat    900

ttcttcctaa aatcttcatc aaacccaatg ctcagaaacc tctccctcaa gctctctcta    960

aggaaaggcg ggaacgccca caggatcgtc ctgaggactt ggacgtcccc cctgcactgg   1020

ctgatttcat ccatcagcag agaacccagc aggttgagca agacatgttt gcacatcctt   1080

atcaatatga actaaatcac tttaccccag cagatgcagt gcttcaaaag ccacaacccc   1140

agttatacag acctatagaa gagacaccat gccatttcat atcctccctg gatgaactcg   1200

tggaactcaa cgaaaagctc ttgaattgtc aggaatttgc agttgacttg gagcaccact   1260

cttacaggag cttcctggga ctgacctgcc tgatgcaaat ttctactcgg acggaagact   1320

tcatcattga caccctcgag cttcgaagtg acatgtacat tctcaatgag agcctcacag   1380

acccagccat cgttaaggtc tttcatggtg ctgattcaga catagaatgg ctacagaaag   1440

actttgggtt gtatgtagta aacatgtttg atactcatca ggcagcacgc cttcttaacc   1500

tgggcaggca ctcactcgat catctcctga aactctactg caacgtggac tcaaacaagc   1560

aatatcagct ggctgattgg agaatacgcc ctctgcccga ggagatgctc agctacgccc   1620

gggatgacac ccattacctg ctatatatct atgacaaaat gaggctggag atgtgggagc   1680

gcggcaacgg gcagccggtg cagctgcagg tggtgtggca acggagcagg gacatctgcc   1740

tcaagaaatt catcaaacct atcttcacgg atgagtccta ccttgaactc tataggaagc   1800

agaagaagca ccttaacaca cagcagttga cagcctttca gctgctgttt gcctggaggg   1860

ataaaacagc tcgcagggaa gatgaaagtt acggatatgt actgccaaac cacatgatgc   1920

tgaaaatagc tgaagaactg cctaaggaac ctcagggcat catagcttgc tgcaacccag   1980

taccgcccct tgtgcggcag cagatcaacg aaatgcacct tttaatccag caggcccgag   2040

agatgcccct gctcaagtct gaagttgcag ccggagtgaa gaagagcgga ccgctgccca   2100

gtgctgagag attggagaat gttctctttg gacctcacga ctgctcccat gcccctccgg   2160

atggctatcc aatcatccca accagtggat ctgtgccagt tcagaagcag gcgagcctct   2220

tccctgatga aaaagaagat aacttgctgg gtaccacatg cctgattgcc acagctgtca   2280

tcacgttatt taatgaacct agtgctgaag acagtaaaaa gggtccattg acagttgcac   2340

agaaaaaagc ccagaacatc atggagtcct ttgaaaatcc atttaggatg tttctgccct   2400

cactgggaca ccgtgctccc gtctctcagg cagcgaagtt cgatccatca accaaaatct   2460

atgaaatcag caaccgctgg aagctggccc aggtacaagt acaaaaagac tctaaagaag   2520

ctgtcaagaa gaaggcagct gagcaaacag ctgcccggga acaggcaaag gaggcgtgca   2580

aagctgcagc agaacaggcc atctccgtcc gacagcaggt cgtgctagaa aatgctgcaa   2640

agaagagaga gcgagcaaca agcgacccaa ggaccacaga acagaaacaa gagaagaaac   2700

gactcaaaat ttccaagaag ccaaaggacc cagagccacc agaaaaagag tttacgcctt   2760

acgactacag ccagtcagac ttcaaggctt ttgctggaaa cagcaaatcc aaagtttctt   2820

ctcagtttga tccaaataaa cagaccccgt ctggcaagaa atgcattgca gccaaaaaaa   2880

ttaaacagtc ggtgggaaac aaaagcatgt cctttccaac tggaaagtca gacagaggct   2940

tcaggtacaa ctggccacag agatagtcct ggaagacacg tggcgcctgt ggaccggaag   3000

caccaaatgc tggtgctgct tttgtacata catattttta aaccattaaa attcttcctg   3060

aagaaagctg a                                                        3071


<210>  1440
<211>  909
<212>  PRT
<213>  Homo sapiens

<400>  1440

Met Arg Gly Ala His Ala Ser Arg Leu Leu Gly Arg Gln Ala Leu Ala 
1               5                   10                  15


Arg Arg Ala Val Gln Ala Glu Lys Met Ala Pro Pro Ser Thr Arg Glu 
            20                  25                  30


Pro Arg Val Leu Ser Ala Thr Ser Ala Thr Lys Ser Asp Gly Glu Met 
        35                  40                  45


Val Leu Pro Gly Phe Pro Asp Ala Asp Ser Phe Val Lys Phe Ala Leu 
    50                  55                  60


Gly Ser Val Val Ala Val Thr Lys Ala Ser Gly Gly Leu Pro Gln Phe 
65                  70                  75                  80


Gly Asp Glu Tyr Asp Phe Tyr Arg Ser Phe Pro Gly Phe Gln Ala Phe 
                85                  90                  95


Cys Glu Thr Gln Gly Asp Arg Leu Leu Gln Cys Met Ser Arg Val Met 
            100                 105                 110


Gln Tyr His Gly Cys Arg Ser Asn Ile Lys Asp Arg Ser Lys Val Thr 
        115                 120                 125


Glu Leu Glu Asp Lys Phe Asp Leu Leu Val Asp Ala Asn Asp Val Ile 
    130                 135                 140


Leu Glu Arg Val Gly Ile Leu Leu Asp Glu Ala Ser Gly Val Asn Lys 
145                 150                 155                 160


Asn Gln Gln Pro Val Leu Pro Ala Gly Leu Gln Val Pro Lys Thr Val 
                165                 170                 175


Val Ser Ser Trp Asn Arg Lys Ala Ala Glu Tyr Gly Lys Lys Ala Lys 
            180                 185                 190


Ser Glu Thr Phe Arg Leu Leu His Ala Lys Asn Ile Ile Arg Pro Gln 
        195                 200                 205


Leu Lys Phe Arg Glu Lys Ile Asp Asn Ser Asn Thr Pro Phe Leu Pro 
    210                 215                 220


Lys Ile Phe Ile Lys Pro Asn Ala Gln Lys Pro Leu Pro Gln Ala Leu 
225                 230                 235                 240


Ser Lys Glu Arg Arg Glu Arg Pro Gln Asp Arg Pro Glu Asp Leu Asp 
                245                 250                 255


Val Pro Pro Ala Leu Ala Asp Phe Ile His Gln Gln Arg Thr Gln Gln 
            260                 265                 270


Val Glu Gln Asp Met Phe Ala His Pro Tyr Gln Tyr Glu Leu Asn His 
        275                 280                 285


Phe Thr Pro Ala Asp Ala Val Leu Gln Lys Pro Gln Pro Gln Leu Tyr 
    290                 295                 300


Arg Pro Ile Glu Glu Thr Pro Cys His Phe Ile Ser Ser Leu Asp Glu 
305                 310                 315                 320


Leu Val Glu Leu Asn Glu Lys Leu Leu Asn Cys Gln Glu Phe Ala Val 
                325                 330                 335


Asp Leu Glu His His Ser Tyr Arg Ser Phe Leu Gly Leu Thr Cys Leu 
            340                 345                 350


Met Gln Ile Ser Thr Arg Thr Glu Asp Phe Ile Ile Asp Thr Leu Glu 
        355                 360                 365


Leu Arg Ser Asp Met Tyr Ile Leu Asn Glu Ser Leu Thr Asp Pro Ala 
    370                 375                 380


Ile Val Lys Val Phe His Gly Ala Asp Ser Asp Ile Glu Trp Leu Gln 
385                 390                 395                 400


Lys Asp Phe Gly Leu Tyr Val Val Asn Met Phe Asp Thr His Gln Ala 
                405                 410                 415


Ala Arg Leu Leu Asn Leu Gly Arg His Ser Leu Asp His Leu Leu Lys 
            420                 425                 430


Leu Tyr Cys Asn Val Asp Ser Asn Lys Gln Tyr Gln Leu Ala Asp Trp 
        435                 440                 445


Arg Ile Arg Pro Leu Pro Glu Glu Met Leu Ser Tyr Ala Arg Asp Asp 
    450                 455                 460


Thr His Tyr Leu Leu Tyr Ile Tyr Asp Lys Met Arg Leu Glu Met Trp 
465                 470                 475                 480


Glu Arg Gly Asn Gly Gln Pro Val Gln Leu Gln Val Val Trp Gln Arg 
                485                 490                 495


Ser Arg Asp Ile Cys Leu Lys Lys Phe Ile Lys Pro Ile Phe Thr Asp 
            500                 505                 510


Glu Ser Tyr Leu Glu Leu Tyr Arg Lys Gln Lys Lys His Leu Asn Thr 
        515                 520                 525


Gln Gln Leu Thr Ala Phe Gln Leu Leu Phe Ala Trp Arg Asp Lys Thr 
    530                 535                 540


Ala Arg Arg Glu Asp Glu Ser Tyr Gly Tyr Val Leu Pro Asn His Met 
545                 550                 555                 560


Met Leu Lys Ile Ala Glu Glu Leu Pro Lys Glu Pro Gln Gly Ile Ile 
                565                 570                 575


Ala Cys Cys Asn Pro Val Pro Pro Leu Val Arg Gln Gln Ile Asn Glu 
            580                 585                 590


Met His Leu Leu Ile Gln Gln Ala Arg Glu Met Pro Leu Leu Lys Ser 
        595                 600                 605


Glu Val Ala Ala Gly Val Lys Lys Ser Gly Pro Leu Pro Ser Ala Glu 
    610                 615                 620


Arg Leu Glu Asn Val Leu Phe Gly Pro His Asp Cys Ser His Ala Pro 
625                 630                 635                 640


Pro Asp Gly Tyr Pro Ile Ile Pro Thr Ser Gly Ser Val Pro Val Gln 
                645                 650                 655


Lys Gln Ala Ser Leu Phe Pro Asp Glu Lys Glu Asp Asn Leu Leu Gly 
            660                 665                 670


Thr Thr Cys Leu Ile Ala Thr Ala Val Ile Thr Leu Phe Asn Glu Pro 
        675                 680                 685


Ser Ala Glu Asp Ser Lys Lys Gly Pro Leu Thr Val Ala Gln Lys Lys 
    690                 695                 700


Ala Gln Asn Ile Met Glu Ser Phe Glu Asn Pro Phe Arg Met Phe Leu 
705                 710                 715                 720


Pro Ser Leu Gly His Arg Ala Pro Val Ser Gln Ala Ala Lys Phe Asp 
                725                 730                 735


Pro Ser Thr Lys Ile Tyr Glu Ile Ser Asn Arg Trp Lys Leu Ala Gln 
            740                 745                 750


Val Gln Val Gln Lys Asp Ser Lys Glu Ala Val Lys Lys Lys Ala Ala 
        755                 760                 765


Glu Gln Thr Ala Ala Arg Glu Gln Ala Lys Glu Ala Cys Lys Ala Ala 
    770                 775                 780


Ala Glu Gln Ala Ile Ser Val Arg Gln Gln Val Val Leu Glu Asn Ala 
785                 790                 795                 800


Ala Lys Lys Arg Glu Arg Ala Thr Ser Asp Pro Arg Thr Thr Glu Gln 
                805                 810                 815


Lys Gln Glu Lys Lys Arg Leu Lys Ile Ser Lys Lys Pro Lys Asp Pro 
            820                 825                 830


Glu Pro Pro Glu Lys Glu Phe Thr Pro Tyr Asp Tyr Ser Gln Ser Asp 
        835                 840                 845


Phe Lys Ala Phe Ala Gly Asn Ser Lys Ser Lys Val Ser Ser Gln Phe 
    850                 855                 860


Asp Pro Asn Lys Gln Thr Pro Ser Gly Lys Lys Cys Ile Ala Ala Lys 
865                 870                 875                 880


Lys Ile Lys Gln Ser Val Gly Asn Lys Ser Met Ser Phe Pro Thr Gly 
                885                 890                 895


Lys Ser Asp Arg Gly Phe Arg Tyr Asn Trp Pro Gln Arg 
            900                 905


<210>  1441
<211>  532
<212>  DNA
<213>  Homo sapiens

<400>  1441
tgaggaagta atggggcccc atacagggac atctgtgcgc agctgagaga aatgggcctg     60

gttttcagac tgcccacagg gaccaggatc gctatgtatt catttatgtg agccatgagc    120

cctagcccct catcgtgaca ggggtgctct cacagccaag gcttccctga gtgtcatggt    180

cccggcctcg ctgtgagcct gtgatgtgtg gtaactcatt gacctgaccg caggtctctc    240

tcatctctta cctttcagga aacagcaaat ccaaagtttc ttctcagttt gatccaaata    300

aacagacccc gtctggcaag aaatgcattg cagccaaaaa aattaaacag tcggtgggaa    360

acaaaagcat gtcctttcca actggaaagt cagacagagg cttcaggtac aactggccac    420

agagatagtc ctggaagaca cgtggcgcct gtggaccgga agcaccaaat gctggtgctg    480

cttttgtaca tacatatttt taaaccatta aaattcttcc tgaagaaagc tg            532


<210>  1442
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  1442

Thr Val Gly Gly Lys Gln Lys His Val Leu Ser Asn Trp Lys Val Arg 
1               5                   10                  15


Gln Arg Leu Gln Val Gln Leu Ala Thr Glu Ile Val Leu Glu Asp Thr 
            20                  25                  30


Trp Arg Leu Trp Thr Gly Ser Thr Lys Cys Trp Cys Cys Phe Cys Thr 
        35                  40                  45


Tyr Ile Phe Leu Asn His 
    50


<210>  1443
<211>  2682
<212>  DNA
<213>  Homo sapiens

<400>  1443
gttttatgag ttgctggggt agctgatcag tactgtctgc ccttgggaag aaatgaggtg     60

aggaaaaaga tatgcaaagg aatggactcc tggatgggcc tgtcttctca gcagaggagg    120

aggtcagaaa caggcgccac cagcgtgcta aaatcctcca ggagcagttc ttaccttgcc    180

agacggggtc tgtttatttg gatcaaactg agaagaaact ttggatttgc tgtttcctga    240

aagttgagtg gtctggcata tttaccataa acacagtgga agaaggttaa gaggaattac    300

aatatcaatc ttgtggaggt ttcggaaatg aggtagacac taatagccaa gctaaggtga    360

accggaaaga agtcaggact taatataaag cacagggcaa gccccctaag atatccaagg    420

aagatcctga ccacaagcag gggcatcgtt tttcaaagga aaaaggagaa aagctggcac    480

ataccacgac ctgctgtcgg acggagatgg cctgttctgc tgcagctttg cacgcctcct    540

ttgcctgttc ccgggcagct gcaagggaga gaacttgtct ctggagttgg tgaatccagc    600

aaccaccctc ccctccatct ccatccccct ccgacttggc ctagccacag gggttgtcac    660

ggctgattcc tcctccctct caggtccccg gtcccccatc tctgcaggac aggctgcctc    720

agagctcagg ctcaggtgct ctgcccacct tcagctacac gtgagctgat cctccccagc    780

cctgcctgct cctcttctgt gaacctaaat gctcagtggc ctgtggacct gagggcgttt    840

aacaggatcg tcaccatcac catcgtggac aaacctgctc aaaccagcta ctttggctgc    900

cagcaactcc agctttccag ctgctcagga caaaaccttc atccaaggtt cccttccctt    960

ttctcacatg ccacatccac ctcatcatca aatgctgtca gctttgctat gggacagatc   1020

aaggctctga cagcttctca ccacctcctc tgctcccacg ctggtctcaa agccaccatc   1080

ccctctcgcc tgagccactg ccatgtctcc tatcccttcc tggactccca tcctgtcctc   1140

tatagtctac tgttgacaca gcagccagag tgccacatgt cagtcacttc cccccgtctg   1200

ctcagcaccc tcctggcttc tgaactcaga gtaaaaggca gcgtcatccc gtgggcctct   1260

gctggctcct tccccatctc ctgctcttct ctacccgctc tgctcatgca ggcccacttg   1320

ctgctgctca gcatgcccag tgaactagcc ccagggcctc tgggctcgct gtgctgtggc   1380

tccagaactc ttctctaggt cactgcaggt ctcgtcaatg tcgcattcat tagactgcct   1440

tctccaacca ccaacgagac agctacagca cctccagcac tccccaccaa tctctctgca   1500

cagcacctgc tgccatctgc caggatagat actgattgcc caccatccct cagcagaagg   1560

gaagccccac aggggcttca ttcatcgccg tatctggcac ttggctgaaa cagcgggtgt   1620

gcaacagcca ttctttaaca gccgactgag ttgcaaggaa gtgagtgtta cctgtttgct   1680

cagctgcctt cttcttgaca gcttctttag agtctttttg tacttgtacc tgggccagct   1740

tccagcggtt gctgatctat aatgaaagca aatataacaa aaaaaaccct ccaaagtcag   1800

ccacctaagt ctgtcttact tttcatgagg tgacgaaggg caggttaacc taagaagtac   1860

acacattcta agtcataaat tttcaaatct aagggcatga aaaataaatt tcatgctggc   1920

tttattgcta aaatccctat taaggacaaa gtgctactgt cctccaggca ctgggccatc   1980

catcatctca ttcaatccct ctgtaaccct gggaaaaagg tactgtcatc accctctctt   2040

tagagatgag caaacagact ccgggagagt aaataacttg tccaagggac atggtcagta   2100

aatgacagaa gcagactcaa ggctgggctt ccgcaagtct gctgtgtttc tttatgacac   2160

cccacggacc tatggcgtta caacacatgg aggtgacact gggcataaca cacaggacgt   2220

gcagttgttc agtgtgacat aacccgtggg gggaaaagag gagagaaggc agaagcccca   2280

cctgattccc catttccaaa aatagcaagc taactcaggg acaggaacgg ggctggggga   2340

cctctcggtt ttgcctaaca aaagagctct gctgccacac agaggaagcc agtcgcccat   2400

gtcatcagag cagacgcttc ctaaagggag gaaggaggct gcgaacaaca gttcacgttc   2460

tggctctggg gaacatctca agagggtcta ggggaggtgt gctctcattc ttactcataa   2520

tgctggtaaa aacaagccag ataagtaaga tagagtgttt taaaattaaa gctgtcacct   2580

ttaagagcct taaagtaaca gacatctata aaaatgcatc aagctgtata tttaatattt   2640

gtgtacttta ctacatatag attaaacctc aatttaaaaa cc                      2682


<210>  1444
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  1444

Met Gln Arg Asn Gly Leu Leu Asp Gly Pro Val Phe Ser Ala Glu Glu 
1               5                   10                  15


Glu Val Arg Asn Arg Arg His Gln Arg Ala Lys Ile Leu Gln Glu Gln 
            20                  25                  30


Phe Leu Pro Cys Gln Thr Gly Ser Val Tyr Leu Asp Gln Thr Glu Lys 
        35                  40                  45


Lys Leu Trp Ile Cys Cys Phe Leu Lys Val Glu Trp Ser Gly Ile Phe 
    50                  55                  60


Thr Ile Asn Thr Val Glu Glu Gly 
65                  70


<210>  1445
<211>  1018
<212>  DNA
<213>  Homo sapiens

<400>  1445
atccaagata gatcaactct ccctaaaggc tgacagtgaa ctcttggggc cgttttattc     60

tctgaggtta gcaaggagtc atctactagc cattcaggag gccagctggg aagacaaaat    120

aggcacccca aactcagcaa cttcataaca ccttcctctc cccgcctgaa gccttaaact    180

gcatcaagtc aaagaaacct ggggcaaatc cttaacatgt ttttgactgc agtaaatcca    240

cagccactct ctactccgag ctggcagatt gagaccaagt attcaacgaa agtgctcact    300

ggaaattgga tggaagagag gagaaagttc accagagaca ctgacaagac accccaatcc    360

atttacagaa aagaatacat ccccttccca gaccacagac cagaccagat ctccaggtgg    420

tatgggaaga ggaaagttga ggggctacct tacaaacacc tgatcaccca ccaccaggag    480

cccccacatc gctacctgat cagcacctat gacgaccatt acaaccggca tggttacaac    540

ccggggctgc ctccactccg cacttggaat ggacagaagt tgctgtggct gccagagaag    600

tctgactttc cccttcttgc tccccctaca aactatggac tctatgagca gctcaagcag    660

agacagctca cacccaaggc tggcctgaag cagagcactt atacttcatc ctaccccaga    720

ccaccgttgt gcgctatgtc ctggagggag catgcggtcc cggtccctcc ccatcgcctg    780

catcctttcc cacacttctg agagctgcca ccccaggagc agctcagata gaatcagctg    840

gagaccacag catcactgga cttgccagac aacaagtggc gcagataaac tcagagtacg    900

agatctggcc cgtcaaaggt gctctcagaa tcatcatctg catttggcgg tacctgtccc    960

ccctcaaaac ccacaggttc ctttcttttc catccaacaa ttaaagatct ttgacact     1018


<210>  1446
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  1446

Met Phe Leu Thr Ala Val Asn Pro Gln Pro Leu Ser Thr Pro Ser Trp 
1               5                   10                  15


Gln Ile Glu Thr Lys Tyr Ser Thr Lys Val Leu Thr Gly Asn Trp Met 
            20                  25                  30


Glu Glu Arg Arg Lys Phe Thr Arg Asp Thr Asp Lys Thr Pro Gln Ser 
        35                  40                  45


Ile Tyr Arg Lys Glu Tyr Ile Pro Phe Pro Asp His Arg Pro Asp Gln 
    50                  55                  60


Ile Ser Arg Trp Tyr Gly Lys Arg Lys Val Glu Gly Leu Pro Tyr Lys 
65                  70                  75                  80


His Leu Ile Thr His His Gln Glu Pro Pro His Arg Tyr Leu Ile Ser 
                85                  90                  95


Thr Tyr Asp Asp His Tyr Asn Arg His Gly Tyr Asn Pro Gly Leu Pro 
            100                 105                 110


Pro Leu Arg Thr Trp Asn Gly Gln Lys Leu Leu Trp Leu Pro Glu Lys 
        115                 120                 125


Ser Asp Phe Pro Leu Leu Ala Pro Pro Thr Asn Tyr Gly Leu Tyr Glu 
    130                 135                 140


Gln Leu Lys Gln Arg Gln Leu Thr Pro Lys Ala Gly Leu Lys Gln Ser 
145                 150                 155                 160


Thr Tyr Thr Ser Ser Tyr Pro Arg Pro Pro Leu Cys Ala Met Ser Trp 
                165                 170                 175


Arg Glu His Ala Val Pro Val Pro Pro His Arg Leu His Pro Phe Pro 
            180                 185                 190


His Phe 



<210>  1447
<211>  1522
<212>  DNA
<213>  Homo sapiens

<400>  1447
atccaagata gatcaactct ccctaaaggc tgacagtgaa ctcttggggc cgttttattc     60

tctgaggtta gcaaggagtc atctactagc cattcaggag gccagctggg aagacaaaat    120

aggcacccca aactcagcaa cttcataaca ccttcctctc cccgcctgaa gccttaaact    180

gcatcaagtc aaagaaacct ggggcaaatc cttaacatgt ttttgactgc agtaaatcca    240

cagccactct ctactccgag ctggcagatt gagaccaagt attcaacgaa agtgctcact    300

ggaaattgga tggaagagag gagaaagttc accagagaca ctgacaagac accccaatcc    360

atttacagaa aagaatacat ccccttccca gaccacagac cagaccagat ctccaggtgg    420

tatgggaaga ggaaagttga ggggctacct tacaaacacc tgatcaccca ccaccaggag    480

cccccacatc gctacctgat cagcacctat gacgaccatt acaaccggca tggttacaac    540

ccggggctgc ctccactccg cacttggaat ggacagaagt tgctgtggct gccagagaag    600

tctgactttc cccttcttgc tccccctaca aactatggac tctatgagca gctcaagcag    660

agacagctca cacccaaggc tggcctgaag cagagcactt atacttcatc ctaccccaga    720

ccaccgttgt gcgctatgtc ctggagggag catgcggtcc cggtccctcc ccatcgcctg    780

catcctttcc cacacttctg agagctgcca ccccaggagc agctcagata gaatcagctg    840

gagaccacag catcactgga cttgccagac aacaagtggc gcagataaac tcagagtacg    900

agatctggcc cgtcaaaggt gctctcagaa tcatcatctg catttggcgg tacctgtccc    960

ccctcaaaac ccacaggttc ctttcttttc catccaacaa ttaaagatct ttgacactat   1020

tgcagggcta tgtacgtgca caagagtcta ctcccatgga ggaaatgaat ctgatgatga   1080

aacccatcat gaaaactcca cagaatgact gaatgtggtt cccaggaggg cagtgctgca   1140

gagctggcaa tggggaagga ccccagcttg tctgtcattg ccaaggcaga ggaaggcgtg   1200

ctctggcccc acggggctca gaagaagggg aaaacacatg gcatttcctt tgtctctgag   1260

ctcgcaaatc tttgtgtgcg aaagtaaagg atgtcatgag agcaacgggc aggggttgac   1320

ggatgatgaa tgaagacctg gcctgcctag gtagggccag ggagaatcag gtaggtcaag   1380

gccagaaagc tgagggagat tacccagctg aagggacagg ttgggaggga agagagggtg   1440

gcttgggcca tgggggcagc acgtttgaag tctctgactt gggaagaagc tgagcaaatt   1500

ccttaaaagt ccagaaagac ca                                            1522


<210>  1448
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  1448

Met Phe Leu Thr Ala Val Asn Pro Gln Pro Leu Ser Thr Pro Ser Trp 
1               5                   10                  15


Gln Ile Glu Thr Lys Tyr Ser Thr Lys Val Leu Thr Gly Asn Trp Met 
            20                  25                  30


Glu Glu Arg Arg Lys Phe Thr Arg Asp Thr Asp Lys Thr Pro Gln Ser 
        35                  40                  45


Ile Tyr Arg Lys Glu Tyr Ile Pro Phe Pro Asp His Arg Pro Asp Gln 
    50                  55                  60


Ile Ser Arg Trp Tyr Gly Lys Arg Lys Val Glu Gly Leu Pro Tyr Lys 
65                  70                  75                  80


His Leu Ile Thr His His Gln Glu Pro Pro His Arg Tyr Leu Ile Ser 
                85                  90                  95


Thr Tyr Asp Asp His Tyr Asn Arg His Gly Tyr Asn Pro Gly Leu Pro 
            100                 105                 110


Pro Leu Arg Thr Trp Asn Gly Gln Lys Leu Leu Trp Leu Pro Glu Lys 
        115                 120                 125


Ser Asp Phe Pro Leu Leu Ala Pro Pro Thr Asn Tyr Gly Leu Tyr Glu 
    130                 135                 140


Gln Leu Lys Gln Arg Gln Leu Thr Pro Lys Ala Gly Leu Lys Gln Ser 
145                 150                 155                 160


Thr Tyr Thr Ser Ser Tyr Pro Arg Pro Pro Leu Cys Ala Met Ser Trp 
                165                 170                 175


Arg Glu His Ala Val Pro Val Pro Pro His Arg Leu His Pro Phe Pro 
            180                 185                 190


His Phe 



<210>  1449
<211>  1418
<212>  DNA
<213>  Homo sapiens

<400>  1449
ccaagataga tcaactctcc ctaaaggctg acagtgaact cttggggccg ttttattctc     60

tgaggttagc aaggagtcat ctactagcca ttcaggaggc cagctgggaa gacaaaatag    120

gcaccccaaa ctcagcaact tcataacacc ttcctctccc cgcctgaagc cttaaactgc    180

atcaagtcaa agaaacctgg ggcaaatcct taacatgttt ttgactgcag taaatccaca    240

gccactctct actccgagct ggcagattga gaccaagtat tcaacgaaag tgctcactgg    300

aaattggatg gaagagagga gaaagttcac cagagacact gacaagacac cccaatccat    360

ttacagaaaa gaatacatcc ccttcccaga ccacagacca gaccagatct ccaggtggta    420

tgggaagagg aaagttgagg ggctacctta caaacacctg atcacccacc accaggagcc    480

cccacatcgc tacctgatca gcacctatga cgaccattac aaccggcatg gttacaaccc    540

ggggctgcct ccactccgca cttggaatgg acagaagttg ctgtggctgc cagagaagtc    600

tgactttccc cttcttggta cctttataat tcagggtatt cctctgcgtt ggtctgtaaa    660

gttgcacaga ccaacggagc tgtacctgcc tcatgcagaa ggagccacac aggtgaccct    720

ggctccagga gagcagcgga tgacatagta ggggctgagt tctattgtac cctcagggct    780

gcctcctgtc ctttcccttt gacctggggt aatcttggct gtgtaatgaa gccatcacct    840

gtgccccatg gtggcgggct tagagcacag gtggcaggga gcaacatcca cgcatccttc    900

ctcccagtct tatttactac atgaataatg acaatatttc ccaggtagtg ctccctgctg    960

caatgataac aaacactgag gaatttctgg actcggggag ttgacattcc aggggggaaa   1020

cagataagac accattaaaa agtaagaaca cttaagatca catagataat tttagacagg   1080

agtgtgcgct ataaagaaaa caggtaatgg agagaaagtg aggtggtgaa tttgtgaacc   1140

tcctttggtt cacaaattcc tccttggaaa agtgaggggt ggtctttgtt gaggagatag   1200

agttgaattg ggaagaaggg agccatacag ggattgaggg ggaggacatt ccagaggaag   1260

gaacagtaaa tgaaaaagtt ctaaggcagg aatggaggag gatcatgtag gggttcatag   1320

ggcacagtga agggaatgaa atttgtccta tccacaatcc caagacttgg aatgcacttt   1380

tgtaggagag tgccttgatg tgatttacat ttcaagcc                           1418


<210>  1450
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  1450

Met Phe Leu Thr Ala Val Asn Pro Gln Pro Leu Ser Thr Pro Ser Trp 
1               5                   10                  15


Gln Ile Glu Thr Lys Tyr Ser Thr Lys Val Leu Thr Gly Asn Trp Met 
            20                  25                  30


Glu Glu Arg Arg Lys Phe Thr Arg Asp Thr Asp Lys Thr Pro Gln Ser 
        35                  40                  45


Ile Tyr Arg Lys Glu Tyr Ile Pro Phe Pro Asp His Arg Pro Asp Gln 
    50                  55                  60


Ile Ser Arg Trp Tyr Gly Lys Arg Lys Val Glu Gly Leu Pro Tyr Lys 
65                  70                  75                  80


His Leu Ile Thr His His Gln Glu Pro Pro His Arg Tyr Leu Ile Ser 
                85                  90                  95


Thr Tyr Asp Asp His Tyr Asn Arg His Gly Tyr Asn Pro Gly Leu Pro 
            100                 105                 110


Pro Leu Arg Thr Trp Asn Gly Gln Lys Leu Leu Trp Leu Pro Glu Lys 
        115                 120                 125


Ser Asp Phe Pro Leu Leu Gly Thr Phe Ile Ile Gln Gly Ile Pro Leu 
    130                 135                 140


Arg Trp Ser Val Lys Leu His Arg Pro Thr Glu Leu Tyr Leu Pro His 
145                 150                 155                 160


Ala Glu Gly Ala Thr Gln Val Thr Leu Ala Pro Gly Glu Gln Arg Met 
                165                 170                 175


Thr 



<210>  1451
<211>  402
<212>  DNA
<213>  Homo sapiens

<400>  1451
ctctgaggtt agcaaggagt catctactag ccattcagga ggccagctgg gaagacaaaa     60

taggcacccc aaactcagca acttcataac accttcctct ccccgcctga agccttaaac    120

tgcatcaagt caaagaaacc tggggcaaat ccttaacatg tttttgactg cagtaaatcc    180

acagccactc tctactccga gctggcagat tgagaccaag tattcaacga aagtgctcat    240

ggacttgcca gacaacaagt ggcgcagata aactcagagt acgagatctg gcccgtcaaa    300

ggtgctctca gaatcatcat ctgcatttgg cggtacctgt cccccctcaa aacccacagg    360

ttcctttctt ttccatccaa caattaaaga tctttgacac ta                       402


<210>  1452
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  1452

Met Phe Leu Thr Ala Val Asn Pro Gln Pro Leu Ser Thr Pro Ser Trp 
1               5                   10                  15


Gln Ile Glu Thr Lys Tyr Ser Thr Lys Val Leu Met Asp Leu Pro Asp 
            20                  25                  30


Asn Lys Trp Arg Arg 
        35


<210>  1453
<211>  785
<212>  DNA
<213>  Homo sapiens

<400>  1453
taggcacccc aaactcagca acttcataac accttcctct ccccgcctga agccttaaac     60

tgcatcaagt caaagaaacc tggggcaaat ccttaacatg tttttgactg cagtaaatcc    120

acagccactc tctactccga gctggcagat tgagaccaag tattcaacga aagtgctcac    180

tggaaattgg atggaagaga ggagaaaggg gctaccttac aaacacctga tcacccacca    240

ccaggagccc ccacatcgct acctgatcag cacctatgac gaccattaca accggcatgg    300

ttacaacccg gggctgcctc cactccgcac ttggaatgga cagaagttgc tgtggctgcc    360

agagaagtct gactttcccc ttcttgctcc ccctacaaac tatggactct atgagcagct    420

caagcagaga cagctcacac ccaaggctgg cctgaagcag agcacttata cttcatccta    480

ccccagacca ccgttgtgcg ctatgtcctg gagggagcat gcggtcccgg tccctcccca    540

tcgcctgcat cctttcccac acttctgaga gctgccaccc caggagcagc tcagatagaa    600

tcagctggag accacagcat cactggactt gccagacaac aagtggcgca gataaactca    660

gagtacgaga tctggcccgt caaaggtgct ctcagaatca tcatctgcat ttggcggtac    720

ctgtcccccc tcaaaaccca caggttcctt tcttttccat ccaacaatta aagatctttg    780

acact                                                                785


<210>  1454
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  1454

Met Phe Leu Thr Ala Val Asn Pro Gln Pro Leu Ser Thr Pro Ser Trp 
1               5                   10                  15


Gln Ile Glu Thr Lys Tyr Ser Thr Lys Val Leu Thr Gly Asn Trp Met 
            20                  25                  30


Glu Glu Arg Arg Lys Gly Leu Pro Tyr Lys His Leu Ile Thr His His 
        35                  40                  45


Gln Glu Pro Pro His Arg Tyr Leu Ile Ser Thr Tyr Asp Asp His Tyr 
    50                  55                  60


Asn Arg His Gly Tyr Asn Pro Gly Leu Pro Pro Leu Arg Thr Trp Asn 
65                  70                  75                  80


Gly Gln Lys Leu Leu Trp Leu Pro Glu Lys Ser Asp Phe Pro Leu Leu 
                85                  90                  95


Ala Pro Pro Thr Asn Tyr Gly Leu Tyr Glu Gln Leu Lys Gln Arg Gln 
            100                 105                 110


Leu Thr Pro Lys Ala Gly Leu Lys Gln Ser Thr Tyr Thr Ser Ser Tyr 
        115                 120                 125


Pro Arg Pro Pro Leu Cys Ala Met Ser Trp Arg Glu His Ala Val Pro 
    130                 135                 140


Val Pro Pro His Arg Leu His Pro Phe Pro His Phe 
145                 150                 155


<210>  1455
<211>  1867
<212>  DNA
<213>  Homo sapiens

<400>  1455
atgaatgaag acctggcctg cctaggtagg gccagggaga atcaggcagc tgggatggtc     60

aagggacagg ggcaggggga atccgatgag ggccacagac tattcatcag gatgagcctc    120

caggccccac ctagactcct ggagctggct gagcagagtc tgctgagaga ccgggccttg    180

gccatcccca ccctggagga gctgcccagg gagctctttc ccccactgtt catggaggcc    240

tttaccagga gatgctgcga gaccctgaca actatggtgc aggcctggcc cttcacctgc    300

cttcctctag ggtccctgat gaagtcatgt aatctagaga tctttcgagc tgtgctggag    360

gggcttgatg cactgcttgc ccagaaggtt cgccccaggc ggtggaaact tcaagtgttg    420

gacttgcgga atgtggatga gaacttctgg ggcatatggt ctggagcttc tgcactctcc    480

ccagaggccc tgagtaagag acgaacagca gggaactgtc caaggccggg tgggcagcag    540

cccttgatgg tgatcctaga cctttgcttc aagaatggga tgctggatga atgcctcacc    600

cacttcttag agtggggcaa gcagagaaaa ggcttactgc acgtgtgttg caaggagctg    660

cagatttttg gaatagccat ccacaggatc atagaggtcc tgaacacggt ggagctagac    720

tgtatccagg aggtggaagt gtgctgcccg tgggagctgt ccattcttat aaggttcgcc    780

ccttacctgg gccagatgag gaatctccgc aaacttgttc tcttcaacat ccatgtctct    840

gcctgcattc ccctagacag gaaggagcag tttgtcatcc agttcacctc tcagttcctc    900

aagctggact acttccagaa gctttacatg cactctgtct ctttcctcga aggccacctg    960

gaccagctgc tcaggtgtct ccaggccccc ttggagacag tcgtaatgac cgaatgcctg   1020

ctgtcagagt cggacctgaa gcatctctct tggtgcccga gcatccgtca gctaaaagag   1080

ctagacctga ggggcatcac actgacccat ttcagtcctg agcccctctc agttctgctg   1140

gagcaagctg aggccaccct gcagaccctg gacttagagg actgtgggat cgtggattcc   1200

caactcagcg ccatcctgcc tgccctgagc cgctgctccc agctcagcac cttcagcttc   1260

tgtgggaacc tcatctccat ggccgccctg gagaacctgc tgcgccacac cgtcgggctg   1320

agcaagctaa gcctggagct gtatcctgcc cctctggaga gttatgatgc ccagggtgct   1380

ctctgctggg gaagattttc tcaacttggg gctgagctga tgaagacact gagggactta   1440

aggcagccca agattattgt gttcagcact gtcccctgcc ctcgctgtgg catcagggcc   1500

tcctatgacc tggagcccag tcactgtctg ttgaatgcct gctgtcaggg tggatttatt   1560

taaagctttc ttctggtcat ttggcaactg aatcctaggc catgagtgta tgtcaaaggg   1620

agcacagacc catcgtttca tatgcctgct caatgtgaac gggaaaggaa aggggatgca   1680

ggaagggagg gactggggga aaagttgagt tggagtcaat aggagcttta gagacctgtg   1740

tcccagagaa tcagaaatgg gaatctgaat tgctagaatg agaatcaggt aggagagaca   1800

catgagacag ttacccctgc acggatggtt gtaaagaaac agtcagaaat aaagggaagc   1860

tgagtgg                                                             1867


<210>  1456
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  1456

Met Asn Glu Asp Leu Ala Cys Leu Gly Arg Ala Arg Glu Asn Gln Ala 
1               5                   10                  15


Ala Gly Met Val Lys Gly Gln Gly Gln Gly Glu Ser Asp Glu Gly His 
            20                  25                  30


Arg Leu Phe Ile Arg Met Ser Leu Gln Ala Pro Pro Arg Leu Leu Glu 
        35                  40                  45


Leu Ala Glu Gln Ser Leu Leu Arg Asp Arg Ala Leu Ala Ile Pro Thr 
    50                  55                  60


Leu Glu Glu Leu Pro Arg Glu Leu Phe Pro Pro Leu Phe Met Glu Ala 
65                  70                  75                  80


Phe Thr Arg Arg Cys Cys Glu Thr Leu Thr Thr Met Val Gln Ala Trp 
                85                  90                  95


Pro Phe Thr Cys Leu Pro Leu Gly Ser Leu Met Lys Ser Cys Asn Leu 
            100                 105                 110


Glu Ile Phe Arg Ala Val Leu Glu Gly Leu Asp Ala Leu Leu Ala Gln 
        115                 120                 125


Lys Val Arg Pro Arg Arg Trp Lys Leu Gln Val Leu Asp Leu Arg Asn 
    130                 135                 140


Val Asp Glu Asn Phe Trp Gly Ile Trp Ser Gly Ala Ser Ala Leu Ser 
145                 150                 155                 160


Pro Glu Ala Leu Ser Lys Arg Arg Thr Ala Gly Asn Cys Pro Arg Pro 
                165                 170                 175


Gly Gly Gln Gln Pro Leu Met Val Ile Leu Asp Leu Cys Phe Lys Asn 
            180                 185                 190


Gly Met Leu Asp Glu Cys Leu Thr His Phe Leu Glu Trp Gly Lys Gln 
        195                 200                 205


Arg Lys Gly Leu Leu His Val Cys Cys Lys Glu Leu Gln Ile Phe Gly 
    210                 215                 220


Ile Ala Ile His Arg Ile Ile Glu Val Leu Asn Thr Val Glu Leu Asp 
225                 230                 235                 240


Cys Ile Gln Glu Val Glu Val Cys Cys Pro Trp Glu Leu Ser Ile Leu 
                245                 250                 255


Ile Arg Phe Ala Pro Tyr Leu Gly Gln Met Arg Asn Leu Arg Lys Leu 
            260                 265                 270


Val Leu Phe Asn Ile His Val Ser Ala Cys Ile Pro Leu Asp Arg Lys 
        275                 280                 285


Glu Gln Phe Val Ile Gln Phe Thr Ser Gln Phe Leu Lys Leu Asp Tyr 
    290                 295                 300


Phe Gln Lys Leu Tyr Met His Ser Val Ser Phe Leu Glu Gly His Leu 
305                 310                 315                 320


Asp Gln Leu Leu Arg Cys Leu Gln Ala Pro Leu Glu Thr Val Val Met 
                325                 330                 335


Thr Glu Cys Leu Leu Ser Glu Ser Asp Leu Lys His Leu Ser Trp Cys 
            340                 345                 350


Pro Ser Ile Arg Gln Leu Lys Glu Leu Asp Leu Arg Gly Ile Thr Leu 
        355                 360                 365


Thr His Phe Ser Pro Glu Pro Leu Ser Val Leu Leu Glu Gln Ala Glu 
    370                 375                 380


Ala Thr Leu Gln Thr Leu Asp Leu Glu Asp Cys Gly Ile Val Asp Ser 
385                 390                 395                 400


Gln Leu Ser Ala Ile Leu Pro Ala Leu Ser Arg Cys Ser Gln Leu Ser 
                405                 410                 415


Thr Phe Ser Phe Cys Gly Asn Leu Ile Ser Met Ala Ala Leu Glu Asn 
            420                 425                 430


Leu Leu Arg His Thr Val Gly Leu Ser Lys Leu Ser Leu Glu Leu Tyr 
        435                 440                 445


Pro Ala Pro Leu Glu Ser Tyr Asp Ala Gln Gly Ala Leu Cys Trp Gly 
    450                 455                 460


Arg Phe Ser Gln Leu Gly Ala Glu Leu Met Lys Thr Leu Arg Asp Leu 
465                 470                 475                 480


Arg Gln Pro Lys Ile Ile Val Phe Ser Thr Val Pro Cys Pro Arg Cys 
                485                 490                 495


Gly Ile Arg Ala Ser Tyr Asp Leu Glu Pro Ser His Cys Leu Leu Asn 
            500                 505                 510


Ala Cys Cys Gln Gly Gly Phe Ile 
        515                 520


<210>  1457
<211>  1906
<212>  DNA
<213>  Homo sapiens

<400>  1457
atggaaggag ccctggacct ttctcccagt gatgcctccc ctactgtcaa gttcctctgg     60

ccctggagct tccagggacc cctgcatcct ttccttcctg cagccctgcc tttgccaaag    120

ctccatgcat ttgcctccaa attcatcagg atgagcctcc aggccccacc tagactcctg    180

gagctggctg agcagagtct gctgagagac cgggccttgg ccatccccac cctggaggag    240

ctgcccaggg agctctttcc cccactgttc atggaggcct ttaccaggag atgctgcgag    300

accctgacaa ctatggtgca ggcctggccc ttcacctgcc ttcctctagg gtccctgatg    360

aagtcatgta atctagagat ctttcgagct gtgctggagg ggcttgatgc actgcttgcc    420

cagaaggttc gccccaggcg gtggaaactt caagtgttgg acttgcggaa tgtggatgag    480

aacttctggg gcatatggtc tggagcttct gcactctccc cagaggccct gagtaagaga    540

cgaacagcag ggaactgtcc aaggccgggt gggcagcagc ccttgatggt gatcctagac    600

ctttgcttca agaatgggat gctggatgaa tgcctcaccc acttcttaga gtggggcaag    660

cagagaaaag gcttactgca cgtgtgttgc aaggagctgc agatttttgg aatagccatc    720

cacaggatca tagaggtcct gaacacggtg gagctagact gtatccagga ggtggaagtg    780

tgctgcccgt gggagctgtc cattcttata aggttcgccc cttacctggg ccagatgagg    840

aatctccgca aacttgttct cttcaacatc catgtctctg cctgcattcc cctagacagg    900

aaggagcagt ttgtcatcca gttcacctct cagttcctca agctggacta cttccagaag    960

ctttacatgc actctgtctc tttcctcgaa ggccacctgg accagctgct caggtgtctc   1020

caggccccct tggagacagt cgtaatgacc gaatgcctgc tgtcagagtc ggacctgaag   1080

catctctctt ggtgcccgag catccgtcag ctaaaagagc tagacctgag gggcatcaca   1140

ctgacccatt tcagtcctga gcccctctca gttctgctgg agcaagctga ggccaccctg   1200

cagaccctgg acttagagga ctgtgggatc gtggattccc aactcagcgc catcctgcct   1260

gccctgagcc gctgctccca gctcagcacc ttcagcttct gtgggaacct catctccatg   1320

gccgccctgg agaacctgct gcgccacacc gtcgggctga gcaagctaag cctggagctg   1380

tatcctgccc ctctggagag ttatgatgcc cagggtgctc tctgctgggg aagattttct   1440

caacttgggg ctgagctgat gaagacactg agggacttaa ggcagcccaa gattattgtg   1500

ttcagcactg tcccctgccc tcgctgtggc atcagggcct cctatgacct ggagcccagt   1560

cactgtctgt tgaatgcctg ctgtcagggt ggatttattt aaagctttct tctggtcatt   1620

tggcaactga atcctaggcc atgagtgtat gtcaaaggga gcacagaccc atcgtttcat   1680

atgcctgctc aatgtgaacg ggaaaggaaa ggggatgcag gaagggaggg actgggggaa   1740

aagttgagtt ggagtcaata ggagctttag agacctgtgt cccagagaat cagaaatggg   1800

aatctgaatt gctagaatga gaatcaggta ggagagacac atgagacagt tacccctgca   1860

cggatggttg taaagaaaca gtcagaaata aagggaagct gagtgg                  1906


<210>  1458
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  1458

Met Glu Gly Ala Leu Asp Leu Ser Pro Ser Asp Ala Ser Pro Thr Val 
1               5                   10                  15


Lys Phe Leu Trp Pro Trp Ser Phe Gln Gly Pro Leu His Pro Phe Leu 
            20                  25                  30


Pro Ala Ala Leu Pro Leu Pro Lys Leu His Ala Phe Ala Ser Lys Phe 
        35                  40                  45


Ile Arg Met Ser Leu Gln Ala Pro Pro Arg Leu Leu Glu Leu Ala Glu 
    50                  55                  60


Gln Ser Leu Leu Arg Asp Arg Ala Leu Ala Ile Pro Thr Leu Glu Glu 
65                  70                  75                  80


Leu Pro Arg Glu Leu Phe Pro Pro Leu Phe Met Glu Ala Phe Thr Arg 
                85                  90                  95


Arg Cys Cys Glu Thr Leu Thr Thr Met Val Gln Ala Trp Pro Phe Thr 
            100                 105                 110


Cys Leu Pro Leu Gly Ser Leu Met Lys Ser Cys Asn Leu Glu Ile Phe 
        115                 120                 125


Arg Ala Val Leu Glu Gly Leu Asp Ala Leu Leu Ala Gln Lys Val Arg 
    130                 135                 140


Pro Arg Arg Trp Lys Leu Gln Val Leu Asp Leu Arg Asn Val Asp Glu 
145                 150                 155                 160


Asn Phe Trp Gly Ile Trp Ser Gly Ala Ser Ala Leu Ser Pro Glu Ala 
                165                 170                 175


Leu Ser Lys Arg Arg Thr Ala Gly Asn Cys Pro Arg Pro Gly Gly Gln 
            180                 185                 190


Gln Pro Leu Met Val Ile Leu Asp Leu Cys Phe Lys Asn Gly Met Leu 
        195                 200                 205


Asp Glu Cys Leu Thr His Phe Leu Glu Trp Gly Lys Gln Arg Lys Gly 
    210                 215                 220


Leu Leu His Val Cys Cys Lys Glu Leu Gln Ile Phe Gly Ile Ala Ile 
225                 230                 235                 240


His Arg Ile Ile Glu Val Leu Asn Thr Val Glu Leu Asp Cys Ile Gln 
                245                 250                 255


Glu Val Glu Val Cys Cys Pro Trp Glu Leu Ser Ile Leu Ile Arg Phe 
            260                 265                 270


Ala Pro Tyr Leu Gly Gln Met Arg Asn Leu Arg Lys Leu Val Leu Phe 
        275                 280                 285


Asn Ile His Val Ser Ala Cys Ile Pro Leu Asp Arg Lys Glu Gln Phe 
    290                 295                 300


Val Ile Gln Phe Thr Ser Gln Phe Leu Lys Leu Asp Tyr Phe Gln Lys 
305                 310                 315                 320


Leu Tyr Met His Ser Val Ser Phe Leu Glu Gly His Leu Asp Gln Leu 
                325                 330                 335


Leu Arg Cys Leu Gln Ala Pro Leu Glu Thr Val Val Met Thr Glu Cys 
            340                 345                 350


Leu Leu Ser Glu Ser Asp Leu Lys His Leu Ser Trp Cys Pro Ser Ile 
        355                 360                 365


Arg Gln Leu Lys Glu Leu Asp Leu Arg Gly Ile Thr Leu Thr His Phe 
    370                 375                 380


Ser Pro Glu Pro Leu Ser Val Leu Leu Glu Gln Ala Glu Ala Thr Leu 
385                 390                 395                 400


Gln Thr Leu Asp Leu Glu Asp Cys Gly Ile Val Asp Ser Gln Leu Ser 
                405                 410                 415


Ala Ile Leu Pro Ala Leu Ser Arg Cys Ser Gln Leu Ser Thr Phe Ser 
            420                 425                 430


Phe Cys Gly Asn Leu Ile Ser Met Ala Ala Leu Glu Asn Leu Leu Arg 
        435                 440                 445


His Thr Val Gly Leu Ser Lys Leu Ser Leu Glu Leu Tyr Pro Ala Pro 
    450                 455                 460


Leu Glu Ser Tyr Asp Ala Gln Gly Ala Leu Cys Trp Gly Arg Phe Ser 
465                 470                 475                 480


Gln Leu Gly Ala Glu Leu Met Lys Thr Leu Arg Asp Leu Arg Gln Pro 
                485                 490                 495


Lys Ile Ile Val Phe Ser Thr Val Pro Cys Pro Arg Cys Gly Ile Arg 
            500                 505                 510


Ala Ser Tyr Asp Leu Glu Pro Ser His Cys Leu Leu Asn Ala Cys Cys 
        515                 520                 525


Gln Gly Gly Phe Ile 
    530


<210>  1459
<211>  2160
<212>  DNA
<213>  Homo sapiens

<400>  1459
acccacagca ctcattcctg aagctactgg ttggttccct gagaggtccc agaactctgc     60

gaagtgagtc cagcgctgag attttccttg cagatctatc aggatgagca tccaggcccc    120

acccagacta ctggagctgg cagggcagag cctgctgaga gaccaggcct tgtccatctc    180

tgccatggag gagctgccca gggtgctcta tctcccactc ttcatggagg ccttcagcag    240

gagacacttc cagactctga cggtgatggt tcaggcctgg cccttcacct gcctccctct    300

gggatcactg atgaagacgc ttcatttgga gaccttaaaa gcattgctgg aagggcttca    360

tatgctgctt acacagaagg atcgccccag gaggtggaaa cttcaagtgc tggatttgcg    420

ggatgttgac gagaatttct gggccagatg gcctggagcc tgggccctgt cctgcttccc    480

agagaccacg agtaagaggc agacagcaga ggactgtcca aggatgggag agcaccagcc    540

cttaaaggtg ttcatagaca tctgcctcaa ggaaataccc caggatgaat gcctgagata    600

cctcttccag tgggtttacc aaaggagagg tttagtacac ctgtgctgta gtaagctggt    660

caattatcta acgccgatta aatatctcag aaagtcattg aaaataatat acctgaatag    720

tattcaagag ctggaaattc gcaacatgtc ctggccacgt ctgataagaa agcttcgttg    780

ttacctgaag gagatgaaga atcttcgcaa actcgttttc tccaggtgcc atcattacac    840

gtcagataat gaactccaag gacggttagt tgccaaattc agctctgtgt tcctcaggct    900

ggaacacctt cagttgctta aaataaaatt gatcaccttc ttcagtgggc acctggaaca    960

gctgatcagg tgcctccaga accccttgga gaacttggaa ttaacttatg gctacctatt   1020

ggaagaagac atgaagtgtc tctcccagta cccaagcctc ggttacctaa agcatctgaa   1080

tctcagctac gtgctgctgt tccgcatcag tcttgaaccc ctcggagctc tgctggagaa   1140

aattgctgcc tctctcaaaa ccctcatctt ggagggctgt cagatccact actcccaact   1200

cagtgccatc ctgcctgccc tgagccggtg ctcccagctc accaccttct actttggcag   1260

aaattgcatg tctattgacg ccctgaagga cctgctgcgc cacaccagtg ggctgagcaa   1320

gttaagcctg gagacgtatc ctgcccctga ggagagtttg aattccttgg ttcgtgtcaa   1380

ttgggagatc ttcaccccac ttcgggctga gctgatgtgt acactgaggg aagtcaggca   1440

gcccaagagg atcttcattg gccccacccc ctgcccttcc tgtggctcat caccgtctga   1500

ggaactggag ctccatcttt gctgctaggg aaggcgtgcc cagtggggta gagaaatcca   1560

aagttctctt ccaggcactt ggacactaaa atctactatg tgggtgcaaa ctatttttct   1620

cttttcttat ttatttcatt ttttaataat tccaaaattt ttattaaaga caatttgaga   1680

cagggtttcg ctgtgttgct ccagctggtc tcaaactgct gggcttatgg gatcctcctg   1740

cctcagcttc ctaaagtgct gggattactg gcatgagtga ctgtgtccag gccacatgca   1800

acttaaagga agcacaggca agtgttcagt gtgagggaaa aaacataaca gcagggggca   1860

aggttggagg aaaatgttga ggtgacatca gtgagaactt cagggacccg tgtcctagag   1920

tcggaaagag aagctaaagt tctacagtga tgagactgtt atccctgcaa ggatggttac   1980

caaggaatat cagcaataaa gagcacctga atgaaaactt ttaacctgtt gtgcaattta   2040

tccatcagaa atctctagtt atcgagttac ggatggaaaa ataacgaaat actaatttgt   2100

ctgtgattga gtttcagttg tagaacatca aagcaaccaa ataaaaatta gatcattttg   2160


<210>  1460
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  1460

Met Ser Ile Gln Ala Pro Pro Arg Leu Leu Glu Leu Ala Gly Gln Ser 
1               5                   10                  15


Leu Leu Arg Asp Gln Ala Leu Ser Ile Ser Ala Met Glu Glu Leu Pro 
            20                  25                  30


Arg Val Leu Tyr Leu Pro Leu Phe Met Glu Ala Phe Ser Arg Arg His 
        35                  40                  45


Phe Gln Thr Leu Thr Val Met Val Gln Ala Trp Pro Phe Thr Cys Leu 
    50                  55                  60


Pro Leu Gly Ser Leu Met Lys Thr Leu His Leu Glu Thr Leu Lys Ala 
65                  70                  75                  80


Leu Leu Glu Gly Leu His Met Leu Leu Thr Gln Lys Asp Arg Pro Arg 
                85                  90                  95


Arg Trp Lys Leu Gln Val Leu Asp Leu Arg Asp Val Asp Glu Asn Phe 
            100                 105                 110


Trp Ala Arg Trp Pro Gly Ala Trp Ala Leu Ser Cys Phe Pro Glu Thr 
        115                 120                 125


Thr Ser Lys Arg Gln Thr Ala Glu Asp Cys Pro Arg Met Gly Glu His 
    130                 135                 140


Gln Pro Leu Lys Val Phe Ile Asp Ile Cys Leu Lys Glu Ile Pro Gln 
145                 150                 155                 160


Asp Glu Cys Leu Arg Tyr Leu Phe Gln Trp Val Tyr Gln Arg Arg Gly 
                165                 170                 175


Leu Val His Leu Cys Cys Ser Lys Leu Val Asn Tyr Leu Thr Pro Ile 
            180                 185                 190


Lys Tyr Leu Arg Lys Ser Leu Lys Ile Ile Tyr Leu Asn Ser Ile Gln 
        195                 200                 205


Glu Leu Glu Ile Arg Asn Met Ser Trp Pro Arg Leu Ile Arg Lys Leu 
    210                 215                 220


Arg Cys Tyr Leu Lys Glu Met Lys Asn Leu Arg Lys Leu Val Phe Ser 
225                 230                 235                 240


Arg Cys His His Tyr Thr Ser Asp Asn Glu Leu Gln Gly Arg Leu Val 
                245                 250                 255


Ala Lys Phe Ser Ser Val Phe Leu Arg Leu Glu His Leu Gln Leu Leu 
            260                 265                 270


Lys Ile Lys Leu Ile Thr Phe Phe Ser Gly His Leu Glu Gln Leu Ile 
        275                 280                 285


Arg Cys Leu Gln Asn Pro Leu Glu Asn Leu Glu Leu Thr Tyr Gly Tyr 
    290                 295                 300


Leu Leu Glu Glu Asp Met Lys Cys Leu Ser Gln Tyr Pro Ser Leu Gly 
305                 310                 315                 320


Tyr Leu Lys His Leu Asn Leu Ser Tyr Val Leu Leu Phe Arg Ile Ser 
                325                 330                 335


Leu Glu Pro Leu Gly Ala Leu Leu Glu Lys Ile Ala Ala Ser Leu Lys 
            340                 345                 350


Thr Leu Ile Leu Glu Gly Cys Gln Ile His Tyr Ser Gln Leu Ser Ala 
        355                 360                 365


Ile Leu Pro Ala Leu Ser Arg Cys Ser Gln Leu Thr Thr Phe Tyr Phe 
    370                 375                 380


Gly Arg Asn Cys Met Ser Ile Asp Ala Leu Lys Asp Leu Leu Arg His 
385                 390                 395                 400


Thr Ser Gly Leu Ser Lys Leu Ser Leu Glu Thr Tyr Pro Ala Pro Glu 
                405                 410                 415


Glu Ser Leu Asn Ser Leu Val Arg Val Asn Trp Glu Ile Phe Thr Pro 
            420                 425                 430


Leu Arg Ala Glu Leu Met Cys Thr Leu Arg Glu Val Arg Gln Pro Lys 
        435                 440                 445


Arg Ile Phe Ile Gly Pro Thr Pro Cys Pro Ser Cys Gly Ser Ser Pro 
    450                 455                 460


Ser Glu Glu Leu Glu Leu His Leu Cys Cys 
465                 470


<210>  1461
<211>  1323
<212>  DNA
<213>  Homo sapiens

<400>  1461
ggggtcacct ggggtagaag ctagagaggg acatcatgta caagctagtt agtgggggtt     60

tcagctctat tgggggtgca cgtgtgaatt tcctgttaca aagtgtgttt caagttgata    120

tgatgtcaaa gagataatag aggagggtat gaaaggaggg aaagcgcatc aaacctgtcc    180

atttcacaat agaacgtctg tcctcaccgg cttagtgatc acgaatgatc ctgtctctga    240

ttccctgttt gtaaaaggtt gttttgaact ccaggaaagg tgcctccaga accccttgga    300

gaacttggaa ttaacttatg gctacctatt ggaagaagac atgaagtgtc tctcccagta    360

cccaagcctc ggttacctaa agcatctgaa tctcagctac gtgctgctgt tccgcatcag    420

tcttgaaccc ctcggagctc tgctggagaa aattgctgcc tctctcaaaa ccctcatctt    480

ggagggctgt cagatccact actcccaact cagtgccatc ctgcctgccc tgagccggtg    540

ctcccagctc accaccttct actttggcag aaattgcatg tctattgacg ccctgaagga    600

cctgctgcgc cacaccagtg ggctgagcaa gttaagcctg gagacgtatc ctgcccctga    660

ggagagtttg aattccttgg ttcgtgtcaa ttgggagatc ttcaccccac ttcgggctga    720

gctgatgtgt acactgaggg aagtcaggca gcccaagagg atcttcattg gccccacccc    780

ctgcccttcc tgtggctcat caccgtctga ggaactggag ctccatcttt gctgctaggg    840

aaggcgtgcc cagtggggta gagaaatcca aagttctctt ccaggcactt ggacactaaa    900

atctactatg tgggtgcaaa ctatttttct cttttcttat ttatttcatt ttttaataat    960

tccaaaattt ttattaaaga caatttgaga cagggtttcg ctgtgttgct ccagctggtc   1020

tcaaactgct gggcttatgg gatcctcctg cctcagcttc ctaaagtgct gggattactg   1080

gcatgagtga ctgtgtccag gccacatgca acttaaagga agcacaggca agtgttcagt   1140

gtgagggaaa aaacataaca gcagggggca aggttggagg aaaatgttga ggtgacatca   1200

gtgagaactt cagggacccg tgtcctagag tcggaaagag aagctaaagt tctacagtga   1260

tgagactgtt atccctgcaa ggatggttac caaggaatat cagcaataaa gagcacctga   1320

atg                                                                 1323


<210>  1462
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  1462

Met Lys Gly Gly Lys Ala His Gln Thr Cys Pro Phe His Asn Arg Thr 
1               5                   10                  15


Ser Val Leu Thr Gly Leu Val Ile Thr Asn Asp Pro Val Ser Asp Ser 
            20                  25                  30


Leu Phe Val Lys Gly Cys Phe Glu Leu Gln Glu Arg Cys Leu Gln Asn 
        35                  40                  45


Pro Leu Glu Asn Leu Glu Leu Thr Tyr Gly Tyr Leu Leu Glu Glu Asp 
    50                  55                  60


Met Lys Cys Leu Ser Gln Tyr Pro Ser Leu Gly Tyr Leu Lys His Leu 
65                  70                  75                  80


Asn Leu Ser Tyr Val Leu Leu Phe Arg Ile Ser Leu Glu Pro Leu Gly 
                85                  90                  95


Ala Leu Leu Glu Lys Ile Ala Ala Ser Leu Lys Thr Leu Ile Leu Glu 
            100                 105                 110


Gly Cys Gln Ile His Tyr Ser Gln Leu Ser Ala Ile Leu Pro Ala Leu 
        115                 120                 125


Ser Arg Cys Ser Gln Leu Thr Thr Phe Tyr Phe Gly Arg Asn Cys Met 
    130                 135                 140


Ser Ile Asp Ala Leu Lys Asp Leu Leu Arg His Thr Ser Gly Leu Ser 
145                 150                 155                 160


Lys Leu Ser Leu Glu Thr Tyr Pro Ala Pro Glu Glu Ser Leu Asn Ser 
                165                 170                 175


Leu Val Arg Val Asn Trp Glu Ile Phe Thr Pro Leu Arg Ala Glu Leu 
            180                 185                 190


Met Cys Thr Leu Arg Glu Val Arg Gln Pro Lys Arg Ile Phe Ile Gly 
        195                 200                 205


Pro Thr Pro Cys Pro Ser Cys Gly Ser Ser Pro Ser Glu Glu Leu Glu 
    210                 215                 220


Leu His Leu Cys Cys 
225


<210>  1463
<211>  1470
<212>  DNA
<213>  Homo sapiens

<400>  1463
ggggtcacct ggggtagaag ctagagaggg acatcatgta caagctagtt agtgggggtt     60

tcagctctat tgggggtgca cgtgtgaatt tcctgttaca aagtgtgttt caagttgata    120

tgatgtcaaa gagataatag aggagggtat gaaaggaggg aaagcgcatc aaacctgtcc    180

atttcacaat agaacgtctg tcctcaccgg cttagtgatc acgaatgatc ctgtctctga    240

ttccctgttt gtaaaaggtt gttttgaact ccaggaaagg tgcctccaga accccttgga    300

gaacttggaa ttaacttatg gctacctatt ggaagaagac atgaagtgtc tctcccagta    360

cccaagcctc ggttacctaa agcatctgaa tctcagctac gtgctgctgt tccgcatcag    420

tcttgaaccc ctcggagctc tgctggagaa aattgctgcc tctctcaaaa ccctcatctt    480

ggagggctgt cagatccact actcccaact cagtgccatc ctgcctgccc tgagccggtg    540

ctcccagctc accaccttct actttggcag aaattgcatg tctattgacg ccctgaagga    600

cctgctgcgc cacaccagtg ggctgagcaa gttaagcctg gagacgtatc ctgcccctga    660

ggagagtttg aattccttgg ttcgtgtcaa ttgggagatc ttcaccccac ttcgggctga    720

gctgatgtgt acactgaggg aagtcaggca gcccaagagg atcttcattg gccccacccc    780

ctgcccttcc tgtggctcat caccgtctga ggaactggag ctccatcttt gctgctaggg    840

aaggcgtgcc cagtggggta gagaaatcca aagttctctt ccaggcactt ggacactaaa    900

atctactatg tgggtgcaaa ctatttttct cttttcttat ttatttcatt ttttaataat    960

tccaaaattt ttattaaaga caatttgaga cagggtttcg ctgtgttgct ccagctggtc   1020

tcaaactgct gggcttatgg gatcctcctg cctcagcttc ctaaagtgct gggattactg   1080

gcatgagtga ctgtgtccag gccacatgca acttaaagga agcacaggca agtgttcagt   1140

gtgagggaaa aaacataaca gcagggggca aggttggagg aaaatgttga ggtgacatca   1200

gtgagaactt cagggacccg tgtcctagag tcggaaagag aagctaaagt tctacagtga   1260

tgagactgtt atccctgcaa ggatggttac caaggaatat cagcaataaa gagcacctga   1320

atgaaaactt ttaacctgtt gtgcaattta tccatcagaa atctctagtt atcgagttac   1380

ggatggaaaa ataacgaaat actaatttgt ctgtgattga gtttcagttg tagaacatca   1440

aagcaaccaa ataaaaatta gatcattttg                                    1470


<210>  1464
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  1464

Met Lys Gly Gly Lys Ala His Gln Thr Cys Pro Phe His Asn Arg Thr 
1               5                   10                  15


Ser Val Leu Thr Gly Leu Val Ile Thr Asn Asp Pro Val Ser Asp Ser 
            20                  25                  30


Leu Phe Val Lys Gly Cys Phe Glu Leu Gln Glu Arg Cys Leu Gln Asn 
        35                  40                  45


Pro Leu Glu Asn Leu Glu Leu Thr Tyr Gly Tyr Leu Leu Glu Glu Asp 
    50                  55                  60


Met Lys Cys Leu Ser Gln Tyr Pro Ser Leu Gly Tyr Leu Lys His Leu 
65                  70                  75                  80


Asn Leu Ser Tyr Val Leu Leu Phe Arg Ile Ser Leu Glu Pro Leu Gly 
                85                  90                  95


Ala Leu Leu Glu Lys Ile Ala Ala Ser Leu Lys Thr Leu Ile Leu Glu 
            100                 105                 110


Gly Cys Gln Ile His Tyr Ser Gln Leu Ser Ala Ile Leu Pro Ala Leu 
        115                 120                 125


Ser Arg Cys Ser Gln Leu Thr Thr Phe Tyr Phe Gly Arg Asn Cys Met 
    130                 135                 140


Ser Ile Asp Ala Leu Lys Asp Leu Leu Arg His Thr Ser Gly Leu Ser 
145                 150                 155                 160


Lys Leu Ser Leu Glu Thr Tyr Pro Ala Pro Glu Glu Ser Leu Asn Ser 
                165                 170                 175


Leu Val Arg Val Asn Trp Glu Ile Phe Thr Pro Leu Arg Ala Glu Leu 
            180                 185                 190


Met Cys Thr Leu Arg Glu Val Arg Gln Pro Lys Arg Ile Phe Ile Gly 
        195                 200                 205


Pro Thr Pro Cys Pro Ser Cys Gly Ser Ser Pro Ser Glu Glu Leu Glu 
    210                 215                 220


Leu His Leu Cys Cys 
225


<210>  1465
<211>  381
<212>  DNA
<213>  Homo sapiens

<400>  1465
gggcacccaa gtgaaggatc ctgctgtgta ctcaggggct ggtgttgctg tcagggatgt     60

tagcctagag cctcagcttc ctgtaaaatg aggatgatga tatccaacag cttatgggac    120

cttgaagtcc cagcattttt catctttcaa tctcacctcc ttttcctgat aatagagagg    180

caacaagaac tcagggcatg caatggggct caacttctac tctctgccac aatttcatca    240

tgattccccc aaagagcaga gccccaggag ccagcagggg gcagggtggg catttctgga    300

ctggattcat tcataataag atcaaaattt ccaatccgta tgtctcgggt gccatctgct    360

gatagatcgg accagatggt a                                              381


<210>  1466
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  1466

Met Arg Met Met Ile Ser Asn Ser Leu Trp Asp Leu Glu Val Pro Ala 
1               5                   10                  15


Phe Phe Ile Phe Gln Ser His Leu Leu Phe Leu Ile Ile Glu Arg Gln 
            20                  25                  30


Gln Glu Leu Arg Ala Cys Asn Gly Ala Gln Leu Leu Leu Ser Ala Thr 
        35                  40                  45


Ile Ser Ser 
    50


<210>  1467
<211>  1850
<212>  DNA
<213>  Homo sapiens

<400>  1467
agtcttcaag cctggagttc ctgcttggtt cttcctgagg tctgagcacc ttctagacta     60

catccagatc tgttttccct gcagattcat gaagatgagc atccggattc cacccagact    120

cctggagctt gcgggcggag cctgctgagg gaccaagcct tggccgtctc caccctggag    180

gagctgccca cggaactttt ccccccactg ttcatggagg ccttcagcag gagacgctgt    240

gaggccctga agctgatggt gcaggcctgg cccttccgcc gcctccctct gaggcctctg    300

ataaagatgc cttgtctgga ggccttccaa gctgtgctcg atgggcttga tgcactgctt    360

acccaagggg ttcgtcccag gagatggaaa cttcaagtgc tggatttaca ggatgtctgt    420

gagaacttct ggatggtttg gtctgaagct atggcccatg ggtgcttcct caatgccaag    480

aggaacaaaa caccagtgca ggactgtcca aggatgagag aacggcagcc cttgactgtg    540

tttgtagaac tttggctcaa gaacaggact ctggatgaat acctcacctg cctccttcta    600

tgggtcaagc agaggagaga tttactacac ctgtgctgta agaagctgaa aattttggga    660

atgcccttcc gcaatatcag aagcatcctg aaaatggtga acctagactg tatccaggag    720

gtggaagtga attgcaagtg gatactgccc atcctgacac agtttacccc atacctgggc    780

cacttgagga atcttcagaa gctcgttctc tcccacatgg atgtctctcg ctacgtttcc    840

ccagagcaga agaaggagat tgttacccag ttcaccactc agttcctcaa gctgcgctgc    900

ctccaaaagc tttatatgaa ctctgtttct ttcctcgaag gccacctgga ccagctgctc    960

agctgtctga agacctcgtt aaaggtcctc acaataacta actgtgtgct tttggaatca   1020

gacttgaagc atctctccca gtgcccgagt atcagtcaac taaagaccct ggacctgagt   1080

ggcatcagac tgaccaatta cagtcttgtg cctctccaaa ttctcctaga aaaagttgca   1140

gccacccttg agtacctgga tttagatgac tgtggcatca tagactccca agtcaacgcc   1200

atcctgcctg ccctgagccg ctgctttgag ctcaacacct tcagcttctg tggaaatccc   1260

atctgcatgg ccaccctgga gaacctgctg agccacacaa tcatactcaa aaacttatgc   1320

ctggagctgt atcctgcccc gcaggaaagt tatggtgctg atggtactct ctgctggagc   1380

agatttgctc aaattagggc tgagctgatg aagaaagtga ggcacttaag gcaccccaag   1440

aggatcttgt tctgtactga caactgccct gaccatggcg acaggtcatt ttatgacctg   1500

gaggcagatc aatactgctg ttgaatgcct gcctatttgg atgggtatgt caaacgcttt   1560

cttctggaca cttggaaact aaaacctagg tcttaggtac atcctaaagg gagcacagaa   1620

cccatcgttt cacacatggg ctctgaaagt gggaaaggaa agctgatcaa gcaggggcag   1680

gacttggggg aaatgttgcc atggattcga tgggactttg ggaacctgta tcctgtagag   1740

tcgaaaatgg gaatctgaat gtctagagtg gaattcaggc ttgagaatac atgagggagt   1800

tactcttgca tggatggttg taaagaaaca atcagaaata aaggaaaact              1850


<210>  1468
<211>  436
<212>  PRT
<213>  Homo sapiens

<400>  1468

Met Glu Ala Phe Ser Arg Arg Arg Cys Glu Ala Leu Lys Leu Met Val 
1               5                   10                  15


Gln Ala Trp Pro Phe Arg Arg Leu Pro Leu Arg Pro Leu Ile Lys Met 
            20                  25                  30


Pro Cys Leu Glu Ala Phe Gln Ala Val Leu Asp Gly Leu Asp Ala Leu 
        35                  40                  45


Leu Thr Gln Gly Val Arg Pro Arg Arg Trp Lys Leu Gln Val Leu Asp 
    50                  55                  60


Leu Gln Asp Val Cys Glu Asn Phe Trp Met Val Trp Ser Glu Ala Met 
65                  70                  75                  80


Ala His Gly Cys Phe Leu Asn Ala Lys Arg Asn Lys Thr Pro Val Gln 
                85                  90                  95


Asp Cys Pro Arg Met Arg Glu Arg Gln Pro Leu Thr Val Phe Val Glu 
            100                 105                 110


Leu Trp Leu Lys Asn Arg Thr Leu Asp Glu Tyr Leu Thr Cys Leu Leu 
        115                 120                 125


Leu Trp Val Lys Gln Arg Arg Asp Leu Leu His Leu Cys Cys Lys Lys 
    130                 135                 140


Leu Lys Ile Leu Gly Met Pro Phe Arg Asn Ile Arg Ser Ile Leu Lys 
145                 150                 155                 160


Met Val Asn Leu Asp Cys Ile Gln Glu Val Glu Val Asn Cys Lys Trp 
                165                 170                 175


Ile Leu Pro Ile Leu Thr Gln Phe Thr Pro Tyr Leu Gly His Leu Arg 
            180                 185                 190


Asn Leu Gln Lys Leu Val Leu Ser His Met Asp Val Ser Arg Tyr Val 
        195                 200                 205


Ser Pro Glu Gln Lys Lys Glu Ile Val Thr Gln Phe Thr Thr Gln Phe 
    210                 215                 220


Leu Lys Leu Arg Cys Leu Gln Lys Leu Tyr Met Asn Ser Val Ser Phe 
225                 230                 235                 240


Leu Glu Gly His Leu Asp Gln Leu Leu Ser Cys Leu Lys Thr Ser Leu 
                245                 250                 255


Lys Val Leu Thr Ile Thr Asn Cys Val Leu Leu Glu Ser Asp Leu Lys 
            260                 265                 270


His Leu Ser Gln Cys Pro Ser Ile Ser Gln Leu Lys Thr Leu Asp Leu 
        275                 280                 285


Ser Gly Ile Arg Leu Thr Asn Tyr Ser Leu Val Pro Leu Gln Ile Leu 
    290                 295                 300


Leu Glu Lys Val Ala Ala Thr Leu Glu Tyr Leu Asp Leu Asp Asp Cys 
305                 310                 315                 320


Gly Ile Ile Asp Ser Gln Val Asn Ala Ile Leu Pro Ala Leu Ser Arg 
                325                 330                 335


Cys Phe Glu Leu Asn Thr Phe Ser Phe Cys Gly Asn Pro Ile Cys Met 
            340                 345                 350


Ala Thr Leu Glu Asn Leu Leu Ser His Thr Ile Ile Leu Lys Asn Leu 
        355                 360                 365


Cys Leu Glu Leu Tyr Pro Ala Pro Gln Glu Ser Tyr Gly Ala Asp Gly 
    370                 375                 380


Thr Leu Cys Trp Ser Arg Phe Ala Gln Ile Arg Ala Glu Leu Met Lys 
385                 390                 395                 400


Lys Val Arg His Leu Arg His Pro Lys Arg Ile Leu Phe Cys Thr Asp 
                405                 410                 415


Asn Cys Pro Asp His Gly Asp Arg Ser Phe Tyr Asp Leu Glu Ala Asp 
            420                 425                 430


Gln Tyr Cys Cys 
        435


<210>  1469
<211>  1157
<212>  DNA
<213>  Homo sapiens

<400>  1469
atgagcctcc agaccccatc cagactcctg gagctggcag ggcagagcct gctgaggaac     60

cagttcttga ctatcttcac cctggatgag ctgcccaggg aggtctcccc tctgttcatg    120

gaggccttca gcatgagatg ttgtgaggcc ctgaagctga tggtgcaggc ctggccctcc    180

cttcacctcc ctctgggatc cctgatgaag acacctcatc tggagacctt gcaagctgtg    240

ctgaagggac ttgatacact agtgtcccag aaggtttgcc ccagttgagg tggaaacttc    300

aagtgctgga tttgagggat gttgatgaga atttctggac catatggtct ggagtcaggg    360

tcctcccctg ctccccagag gccatgagta agaggcagac agtggagaac tgtccaagga    420

tgggagagtg ccagcccttg aaggtgttca tagacctctg cctgaaggaa accttcggtt    480

atgagcctga attatacgtg agcggccaat ggcagttcat tcctgacttg gattggccat    540

tcctgtgcct gtactacccc cagatgcatt atataagaaa ggtcagtaat atcaaagagc    600

acctggagca cctgctcagg tacctcaaga accccttggg ggcctttaca ttcagtgatg    660

cttacctagc tgatcgggac atggagtgtc tgtctcagta cccaagcctc agtcagctaa    720

aggagctgcg tctgattcat atcctaatgt ggaccaccca tcttgagccc cttggagttc    780

tgctggagaa agttgctgct actctcaaga ccctcgtctt agaggactgt cggatccagg    840

ccccccaact cagggtcccc ctgcctgccc tgagccactg ttcccagctc accaccttct    900

actttcatgg aaatgagacc tccacgaatg ctctgaaaga cctgctgcgt cacacaggcg    960

ggctgagcaa gttaggcctg gacatggatc ctgcccctct ggagtgtctt gacaacaggg   1020

gtcatgccaa ttgggagatc ctcaccccaa ttagggctga gctgatgcgt acactcaggg   1080

aattccaggt ttacaagtgt gtgcagctgg gcccggtcag ccgtttctta aaggaagcac   1140

acagctgtgt gtttcag                                                  1157


<210>  1470
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  1470

Met Ser Lys Arg Gln Thr Val Glu Asn Cys Pro Arg Met Gly Glu Cys 
1               5                   10                  15


Gln Pro Leu Lys Val Phe Ile Asp Leu Cys Leu Lys Glu Thr Phe Gly 
            20                  25                  30


Tyr Glu Pro Glu Leu Tyr Val Ser Gly Gln Trp Gln Phe Ile Pro Asp 
        35                  40                  45


Leu Asp Trp Pro Phe Leu Cys Leu Tyr Tyr Pro Gln Met His Tyr Ile 
    50                  55                  60


Arg Lys Val Ser Asn Ile Lys Glu His Leu Glu His Leu Leu Arg Tyr 
65                  70                  75                  80


Leu Lys Asn Pro Leu Gly Ala Phe Thr Phe Ser Asp Ala Tyr Leu Ala 
                85                  90                  95


Asp Arg Asp Met Glu Cys Leu Ser Gln Tyr Pro Ser Leu Ser Gln Leu 
            100                 105                 110


Lys Glu Leu Arg Leu Ile His Ile Leu Met Trp Thr Thr His Leu Glu 
        115                 120                 125


Pro Leu Gly Val Leu Leu Glu Lys Val Ala Ala Thr Leu Lys Thr Leu 
    130                 135                 140


Val Leu Glu Asp Cys Arg Ile Gln Ala Pro Gln Leu Arg Val Pro Leu 
145                 150                 155                 160


Pro Ala Leu Ser His Cys Ser Gln Leu Thr Thr Phe Tyr Phe His Gly 
                165                 170                 175


Asn Glu Thr Ser Thr Asn Ala Leu Lys Asp Leu Leu Arg His Thr Gly 
            180                 185                 190


Gly Leu Ser Lys Leu Gly Leu Asp Met Asp Pro Ala Pro Leu Glu Cys 
        195                 200                 205


Leu Asp Asn Arg Gly His Ala Asn Trp Glu Ile Leu Thr Pro Ile Arg 
    210                 215                 220


Ala Glu Leu Met Arg Thr Leu Arg Glu Phe Gln Val Tyr Lys Cys Val 
225                 230                 235                 240


Gln Leu Gly Pro Val Ser Arg Phe Leu Lys Glu Ala His Ser Cys Val 
                245                 250                 255


Phe 



<210>  1471
<211>  1108
<212>  DNA
<213>  Homo sapiens

<400>  1471
ctgagctaca actacaacca gaggtctaaa ctacaaccag atctgaattc ttgttgggag     60

ccattttgtg aagagacgaa gactgagctg gtttggctgc atttctggcc tcgagccgca    120

gtcagtttct ccccgtagaa cccggcagta ggagacttag aatcgaatct cttctccctc    180

ccgcctcctg tttttggctt tttgagaaac cttatcatcc aacacaatgg ccagcaacgt    240

taccaacaag atggatcctc actccatgaa ctcccgtgtg ttcattggga atctcaacac    300

tcttgttgtc aagaaatcgg atgtggaggc gatcttttcc aagtatggca aaattgcggg    360

ctgctctgtt cataagggct ttgccttcgt tcaatatgat aaggagaaaa atgcccgggc    420

tgctgtagca ggagaggatg gcagaatgat tgctagccag gttgtagata ttaacctggc    480

tgcagagcca aaagtgaacc gaggaaacgc aggtgtgaaa cgatcagcag cggagatgta    540

cggctcctct tttgacttgg actatggctt tcaacgggat tattatgatg gaatgtacag    600

tttcccagca cgtgtacctc ctcctcctcc cattgctctg gctgtagtgc cctcgaaacg    660

tcaacgtcta tcaggaaaca cctcacgaag gggcaaaagt ggcttcaatt ctaagagtgg    720

aaagcgggga tcttccaagt ctggaaagtt gaaaggtgat gaccttcagg ccattaagca    780

ggagttgacc cagataaaac agaaagtgga ttctctcctg gaaaacctgg aaaaaattga    840

aaaggaacag agcaaacaag aggtagaggt gaaaaatgct aagtcagaag aggagcagag    900

cagtagctcc atgaagaaag atgagactca tgtgaagatg gagtctgagg ggggtgcaga    960

agactctgct gaggaggggg acccactgga tgatgatgtt aatgaagatc agggggatga   1020

ccagctggag ttgatcaagg atgatgaaaa agaggctgag gaaggagagg atgacagaga   1080

cagcaccaat ggccaggatg actcttaa                                      1108


<210>  1472
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  1472

Met Ala Ser Asn Val Thr Asn Lys Met Asp Pro His Ser Met Asn Ser 
1               5                   10                  15


Arg Val Phe Ile Gly Asn Leu Asn Thr Leu Val Val Lys Lys Ser Asp 
            20                  25                  30


Val Glu Ala Ile Phe Ser Lys Tyr Gly Lys Ile Ala Gly Cys Ser Val 
        35                  40                  45


His Lys Gly Phe Ala Phe Val Gln Tyr Asp Lys Glu Lys Asn Ala Arg 
    50                  55                  60


Ala Ala Val Ala Gly Glu Asp Gly Arg Met Ile Ala Ser Gln Val Val 
65                  70                  75                  80


Asp Ile Asn Leu Ala Ala Glu Pro Lys Val Asn Arg Gly Asn Ala Gly 
                85                  90                  95


Val Lys Arg Ser Ala Ala Glu Met Tyr Gly Ser Ser Phe Asp Leu Asp 
            100                 105                 110


Tyr Gly Phe Gln Arg Asp Tyr Tyr Asp Gly Met Tyr Ser Phe Pro Ala 
        115                 120                 125


Arg Val Pro Pro Pro Pro Pro Ile Ala Leu Ala Val Val Pro Ser Lys 
    130                 135                 140


Arg Gln Arg Leu Ser Gly Asn Thr Ser Arg Arg Gly Lys Ser Gly Phe 
145                 150                 155                 160


Asn Ser Lys Ser Gly Lys Arg Gly Ser Ser Lys Ser Gly Lys Leu Lys 
                165                 170                 175


Gly Asp Asp Leu Gln Ala Ile Lys Gln Glu Leu Thr Gln Ile Lys Gln 
            180                 185                 190


Lys Val Asp Ser Leu Leu Glu Asn Leu Glu Lys Ile Glu Lys Glu Gln 
        195                 200                 205


Ser Lys Gln Glu Val Glu Val Lys Asn Ala Lys Ser Glu Glu Glu Gln 
    210                 215                 220


Ser Ser Ser Ser Met Lys Lys Asp Glu Thr His Val Lys Met Glu Ser 
225                 230                 235                 240


Glu Gly Gly Ala Glu Asp Ser Ala Glu Glu Gly Asp Pro Leu Asp Asp 
                245                 250                 255


Asp Val Asn Glu Asp Gln Gly Asp Asp Gln Leu Glu Leu Ile Lys Asp 
            260                 265                 270


Asp Glu Lys Glu Ala Glu Glu Gly Glu Asp Asp Arg Asp Ser Thr Asn 
        275                 280                 285


Gly Gln Asp Asp Ser 
    290


<210>  1473
<211>  830
<212>  DNA
<213>  Homo sapiens

<400>  1473
ctgagctaca actacaacca gaggtctaaa ctacaaccag atctgaattc ttgttgggag     60

ccattttgtg aagagacgaa gactgagctg gtttggctgc atttctggcc tcgagccgca    120

gtcagtttct ccccgtagaa cccggcagta ggagacttag aatcgaatct cttctccctc    180

ccgcctcctg tttttggctt tttgagaaac cttatcatcc aacacaatgg ccagcaacgt    240

taccaacaag atggatcctc actccatgaa ctcccgtgtg ttcattggga atctcaacac    300

tcttgttgtc aagaaatcgg atgtggaggc gatcttttcc aagtatggca aaattgcggg    360

ctgctctgtt cataagggct ttgccttcgt tcaatatgat aaggagaaaa atgcccgggc    420

tgctgtagca ggagaggatg gcagaatgat tgctagccag gttgtagata ttaacctggc    480

tgcagagcca aaagtgaacc gaggaaacgc aggtgtgaaa cgatcagcag cggagatgta    540

cggctcctct tttgacttgg actatggctt tcaacgggat tattatgatg gaatgtacag    600

tttcccagca cgtgtacctc ctcctcctcc cattgctctg gctgtagtgc cctcgaaacg    660

tcaacgtcta tcaggaaaca cctcacgaag gggcaaaagt ggcttcaatt ctaagagtgg    720

aaagcgggga tcttccaagt ctggaaagtt gaaaggtgat gaccttcagg ccattaagca    780

ggagttgacc cagataaaac agaaagtgga ttctctcctg gaaaacctgg               830


<210>  1474
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  1474

Met Ala Ser Asn Val Thr Asn Lys Met Asp Pro His Ser Met Asn Ser 
1               5                   10                  15


Arg Val Phe Ile Gly Asn Leu Asn Thr Leu Val Val Lys Lys Ser Asp 
            20                  25                  30


Val Glu Ala Ile Phe Ser Lys Tyr Gly Lys Ile Ala Gly Cys Ser Val 
        35                  40                  45


His Lys Gly Phe Ala Phe Val Gln Tyr Asp Lys Glu Lys Asn Ala Arg 
    50                  55                  60


Ala Ala Val Ala Gly Glu Asp Gly Arg Met Ile Ala Ser Gln Val Val 
65                  70                  75                  80


Asp Ile Asn Leu Ala Ala Glu Pro Lys Val Asn Arg Gly Asn Ala Gly 
                85                  90                  95


Val Lys Arg Ser Ala Ala Glu Met Tyr Gly Ser Ser Phe Asp Leu Asp 
            100                 105                 110


Tyr Gly Phe Gln Arg Asp Tyr Tyr Asp Gly Met Tyr Ser Phe Pro Ala 
        115                 120                 125


Arg Val Pro Pro Pro Pro Pro Ile Ala Leu Ala Val Val Pro Ser Lys 
    130                 135                 140


Arg Gln Arg Leu Ser Gly Asn Thr Ser Arg Arg Gly Lys Ser Gly Phe 
145                 150                 155                 160


Asn Ser Lys Ser Gly Lys Arg Gly Ser Ser Lys Ser Gly Lys Leu Lys 
                165                 170                 175


Gly Asp Asp Leu Gln Ala Ile Lys Gln Glu Leu Thr Gln Ile Lys Gln 
            180                 185                 190


Lys Val Asp Ser Leu Leu Glu Asn 
        195                 200


<210>  1475
<211>  1642
<212>  DNA
<213>  Homo sapiens

<400>  1475
cctgaagcta ctggttggtt ccctgagagg tcccagaact ctgcaaagtg agtccagcgc     60

tgagattttt cttgcagatc catcaggatg agcatccagg ccccaccgag actactggag    120

ctggcggggc agagcctgct gagagaccag gccttgtcca tctctgccat ggaggagctg    180

cccagggtgc tctatctccc actcttcagg gaggccttca gcaggagaca cttccagact    240

ctgacggtga tggtgcaggc ctggcctttc acctgcctcc ctctggtatc gctgatgaag    300

acgcttcatc tggagccatt gaaagcattg ctggaagggc ttcatatgct gcttacacag    360

aaggatcgcc ccaggaggtg gaaacttcaa gtgctggatt tgcgggatgt tgatgagaat    420

ttctgggcca gatggcctgg agcctgggcc ctgtcctgct tcccagaggc catgagtaag    480

aggcagacag cagaggactg tccaaggacg ggagagcacc agcccttaaa ggtgttcata    540

gacatctgcc tcaaggaaat accccaggat gaatgcctga gatacctctt ccagtgggtt    600

taccaaagga gaggtttagt acacctgtgc tgtagtaagc tggtcaatta tctaacgcca    660

attaaatatc tcagaaagtc attgaaaata atatacatta atagtattgg ggagctggaa    720

attcacaaca cgtgctggcc acatctgata agaaagcttt attgttacct gaaggagatg    780

aagactcttt gcaaactcgt tttctccagg tgccatcatt acacgtcaga taatgaactc    840

gagggatggt tagtcaccag attcacctct gtgttcctca ggctggaaca cctccagttg    900

cttaaaataa aattgatcac cttcttcagt gggcacctgg aacagctgat caggtgcctc    960

cagaacccct tggagaactt ggaattaact tgtggcaacc tattagaaga ggacttgaag   1020

tgtctctccc agttcccaag cctcggttac ctaaagcatc tgaatctcag ctacgtgctg   1080

ctgttccgca tcagtcttga acccctagga gctctgctag agaaaattgc tgcctctctc   1140

gagaccctcg tgttagaggg ctgtcagatc cactactccc aactcagtgc catcctgcct   1200

ggcctgagct gctgctccca gctcaccacc ttctactttg gcagcaattg catgtctatt   1260

gacgccctga aggacctgct gcgccacacc agtgggctga gcaagttaag cctggagacg   1320

tatcctgccc ctgaggagag tttgaattcc ttggttcgtg tcaattggga gatcttcacc   1380

ccacttcggg ctgagctgat gtgtacactg agggaattca ggcagcccaa gaggatcttc   1440

attggcccca ccccctgccc ttcctgtggc tcatcaccgt ctgaggaact ggagctccat   1500

ctttgctgct agggaaggcg tgcccagtgg ggtagagaaa tccaaagttc tcttccaggc   1560

acttggacac taaaatctac tatgtaggtg caaactattt ttctcttttc ttatttattt   1620

cattttttaa taattccaaa at                                            1642


<210>  1476
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  1476

Met Ser Ile Gln Ala Pro Pro Arg Leu Leu Glu Leu Ala Gly Gln Ser 
1               5                   10                  15


Leu Leu Arg Asp Gln Ala Leu Ser Ile Ser Ala Met Glu Glu Leu Pro 
            20                  25                  30


Arg Val Leu Tyr Leu Pro Leu Phe Arg Glu Ala Phe Ser Arg Arg His 
        35                  40                  45


Phe Gln Thr Leu Thr Val Met Val Gln Ala Trp Pro Phe Thr Cys Leu 
    50                  55                  60


Pro Leu Val Ser Leu Met Lys Thr Leu His Leu Glu Pro Leu Lys Ala 
65                  70                  75                  80


Leu Leu Glu Gly Leu His Met Leu Leu Thr Gln Lys Asp Arg Pro Arg 
                85                  90                  95


Arg Trp Lys Leu Gln Val Leu Asp Leu Arg Asp Val Asp Glu Asn Phe 
            100                 105                 110


Trp Ala Arg Trp Pro Gly Ala Trp Ala Leu Ser Cys Phe Pro Glu Ala 
        115                 120                 125


Met Ser Lys Arg Gln Thr Ala Glu Asp Cys Pro Arg Thr Gly Glu His 
    130                 135                 140


Gln Pro Leu Lys Val Phe Ile Asp Ile Cys Leu Lys Glu Ile Pro Gln 
145                 150                 155                 160


Asp Glu Cys Leu Arg Tyr Leu Phe Gln Trp Val Tyr Gln Arg Arg Gly 
                165                 170                 175


Leu Val His Leu Cys Cys Ser Lys Leu Val Asn Tyr Leu Thr Pro Ile 
            180                 185                 190


Lys Tyr Leu Arg Lys Ser Leu Lys Ile Ile Tyr Ile Asn Ser Ile Gly 
        195                 200                 205


Glu Leu Glu Ile His Asn Thr Cys Trp Pro His Leu Ile Arg Lys Leu 
    210                 215                 220


Tyr Cys Tyr Leu Lys Glu Met Lys Thr Leu Cys Lys Leu Val Phe Ser 
225                 230                 235                 240


Arg Cys His His Tyr Thr Ser Asp Asn Glu Leu Glu Gly Trp Leu Val 
                245                 250                 255


Thr Arg Phe Thr Ser Val Phe Leu Arg Leu Glu His Leu Gln Leu Leu 
            260                 265                 270


Lys Ile Lys Leu Ile Thr Phe Phe Ser Gly His Leu Glu Gln Leu Ile 
        275                 280                 285


Arg Cys Leu Gln Asn Pro Leu Glu Asn Leu Glu Leu Thr Cys Gly Asn 
    290                 295                 300


Leu Leu Glu Glu Asp Leu Lys Cys Leu Ser Gln Phe Pro Ser Leu Gly 
305                 310                 315                 320


Tyr Leu Lys His Leu Asn Leu Ser Tyr Val Leu Leu Phe Arg Ile Ser 
                325                 330                 335


Leu Glu Pro Leu Gly Ala Leu Leu Glu Lys Ile Ala Ala Ser Leu Glu 
            340                 345                 350


Thr Leu Val Leu Glu Gly Cys Gln Ile His Tyr Ser Gln Leu Ser Ala 
        355                 360                 365


Ile Leu Pro Gly Leu Ser Cys Cys Ser Gln Leu Thr Thr Phe Tyr Phe 
    370                 375                 380


Gly Ser Asn Cys Met Ser Ile Asp Ala Leu Lys Asp Leu Leu Arg His 
385                 390                 395                 400


Thr Ser Gly Leu Ser Lys Leu Ser Leu Glu Thr Tyr Pro Ala Pro Glu 
                405                 410                 415


Glu Ser Leu Asn Ser Leu Val Arg Val Asn Trp Glu Ile Phe Thr Pro 
            420                 425                 430


Leu Arg Ala Glu Leu Met Cys Thr Leu Arg Glu Phe Arg Gln Pro Lys 
        435                 440                 445


Arg Ile Phe Ile Gly Pro Thr Pro Cys Pro Ser Cys Gly Ser Ser Pro 
    450                 455                 460


Ser Glu Glu Leu Glu Leu His Leu Cys Cys 
465                 470


<210>  1477
<211>  1840
<212>  DNA
<213>  Homo sapiens

<400>  1477
ttcctgcttg gttcttcctg agatctgagc accttctaga ctacatccag atctgttttc     60

cctgcagatt catgaagatg agcatctgga ctccacccag actcctggag cttgcagggc    120

ggagcctgct aagggaccaa gctttggcca tgtccaccct ggaggagctg cccacagaac    180

ttttcccccc actgttcatg gaggccttca gcaggagacg ctgtgaggcc ctgaagctga    240

tggtgcagtc ctggcccttc cgccgcctcc ctctgaggcc tctgataaag atgccttgtc    300

tggaggcctt ccaagctgtg ctcgatgggc tggatgcact gcttaaccta ggggttcgtc    360

ccaggaggtg gaaacttcaa gtgctggatt tacaggatgt ctgtgagaac ttctggatgg    420

tttggtctga agctatggcc catgggtgct tcctcaatgc caagaggaac aaaaaaccag    480

tggaggactg tccaaggatg agaggacggc agcccttgac tgtgttcgta gaactttggc    540

tcaagaacag gactctggat gaatacctca cctgcctcct tctatgggtc aagcagagga    600

aagatttact acacctgtgc tgtaagaagc tgaaaatttt gggaatgccc ttccgcaata    660

tcagaagcat cctgaaaatg gtgaacctag actgtatcca ggaggtggaa gtgaattgca    720

agtgggtact gcccatcctg acacagttta ccccatacct gggccacatg aggaatcttc    780

agaaactcat tctctcccac atggatgtct ctcgctacgt ttccccagag cagaagaagg    840

agattgttac ccagttcacc actcagttcc tcaagctgcg ctgcctccaa aagctttata    900

tgaactctgt ttctttcctc gaaggccacc tggaccagct gctcagctgt ctgaagacct    960

cgttaaagtt cctcacaata actaactgtg tgcttttgga atcagacttg aagcatctat   1020

cccagtgccc gagtatcagt caactaaaga ccctggacct gagtggcatc agactgacca   1080

attacagtct tgtgcctctc caaattctcc tagaaaaagt tgcagccacc cttgagtacc   1140

tggatttaga tgactgtggc atcatagact cccaagtcaa cgccatcttg cctgccctga   1200

gccgctgctt tgagctcaac accttcagct tctgtggaaa tcccatctgc atggccaccc   1260

tggagaacct gctgagccac acaatcatac tcaaaaactt atgcgtggag ctgtatcctg   1320

ccccccggga gagttatggt gctgatggta ctctctgctg gagcagattt gctcaaatta   1380

gggctgagct gatgaacaga gtgagggact taaggcaccc caagaggatc ttgttctgta   1440

ctgactactg ccctgactgt ggcaacaggt cattttatga cctggaggca gatcaatact   1500

gctgttgaat gcctgcctat ttggatgggt atgtcaaacg ctttcttctg gacacttgga   1560

aactaaaacc taggtcttag gtacatccta aagggagcac agaacccatc atttcacaca   1620

taggctctga aagtgggaaa ggaaagctga tcaagcaggg gccggacttg ggggaaatgt   1680

tgccatggat tcgatgggac tttggggacc tgtgtcctgt agagtcgaaa atgggaatct   1740

gaatgtctag agtggaattc aggcttgaga atacatgagg gagttactct tgcatggatg   1800

gttgtaaaga aacaatcaga aataaaggaa aactgagcag                         1840


<210>  1478
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  1478

Met Lys Met Ser Ile Trp Thr Pro Pro Arg Leu Leu Glu Leu Ala Gly 
1               5                   10                  15


Arg Ser Leu Leu Arg Asp Gln Ala Leu Ala Met Ser Thr Leu Glu Glu 
            20                  25                  30


Leu Pro Thr Glu Leu Phe Pro Pro Leu Phe Met Glu Ala Phe Ser Arg 
        35                  40                  45


Arg Arg Cys Glu Ala Leu Lys Leu Met Val Gln Ser Trp Pro Phe Arg 
    50                  55                  60


Arg Leu Pro Leu Arg Pro Leu Ile Lys Met Pro Cys Leu Glu Ala Phe 
65                  70                  75                  80


Gln Ala Val Leu Asp Gly Leu Asp Ala Leu Leu Asn Leu Gly Val Arg 
                85                  90                  95


Pro Arg Arg Trp Lys Leu Gln Val Leu Asp Leu Gln Asp Val Cys Glu 
            100                 105                 110


Asn Phe Trp Met Val Trp Ser Glu Ala Met Ala His Gly Cys Phe Leu 
        115                 120                 125


Asn Ala Lys Arg Asn Lys Lys Pro Val Glu Asp Cys Pro Arg Met Arg 
    130                 135                 140


Gly Arg Gln Pro Leu Thr Val Phe Val Glu Leu Trp Leu Lys Asn Arg 
145                 150                 155                 160


Thr Leu Asp Glu Tyr Leu Thr Cys Leu Leu Leu Trp Val Lys Gln Arg 
                165                 170                 175


Lys Asp Leu Leu His Leu Cys Cys Lys Lys Leu Lys Ile Leu Gly Met 
            180                 185                 190


Pro Phe Arg Asn Ile Arg Ser Ile Leu Lys Met Val Asn Leu Asp Cys 
        195                 200                 205


Ile Gln Glu Val Glu Val Asn Cys Lys Trp Val Leu Pro Ile Leu Thr 
    210                 215                 220


Gln Phe Thr Pro Tyr Leu Gly His Met Arg Asn Leu Gln Lys Leu Ile 
225                 230                 235                 240


Leu Ser His Met Asp Val Ser Arg Tyr Val Ser Pro Glu Gln Lys Lys 
                245                 250                 255


Glu Ile Val Thr Gln Phe Thr Thr Gln Phe Leu Lys Leu Arg Cys Leu 
            260                 265                 270


Gln Lys Leu Tyr Met Asn Ser Val Ser Phe Leu Glu Gly His Leu Asp 
        275                 280                 285


Gln Leu Leu Ser Cys Leu Lys Thr Ser Leu Lys Phe Leu Thr Ile Thr 
    290                 295                 300


Asn Cys Val Leu Leu Glu Ser Asp Leu Lys His Leu Ser Gln Cys Pro 
305                 310                 315                 320


Ser Ile Ser Gln Leu Lys Thr Leu Asp Leu Ser Gly Ile Arg Leu Thr 
                325                 330                 335


Asn Tyr Ser Leu Val Pro Leu Gln Ile Leu Leu Glu Lys Val Ala Ala 
            340                 345                 350


Thr Leu Glu Tyr Leu Asp Leu Asp Asp Cys Gly Ile Ile Asp Ser Gln 
        355                 360                 365


Val Asn Ala Ile Leu Pro Ala Leu Ser Arg Cys Phe Glu Leu Asn Thr 
    370                 375                 380


Phe Ser Phe Cys Gly Asn Pro Ile Cys Met Ala Thr Leu Glu Asn Leu 
385                 390                 395                 400


Leu Ser His Thr Ile Ile Leu Lys Asn Leu Cys Val Glu Leu Tyr Pro 
                405                 410                 415


Ala Pro Arg Glu Ser Tyr Gly Ala Asp Gly Thr Leu Cys Trp Ser Arg 
            420                 425                 430


Phe Ala Gln Ile Arg Ala Glu Leu Met Asn Arg Val Arg Asp Leu Arg 
        435                 440                 445


His Pro Lys Arg Ile Leu Phe Cys Thr Asp Tyr Cys Pro Asp Cys Gly 
    450                 455                 460


Asn Arg Ser Phe Tyr Asp Leu Glu Ala Asp Gln Tyr Cys Cys 
465                 470                 475


<210>  1479
<211>  1525
<212>  DNA
<213>  Homo sapiens

<400>  1479
ttcctgctta gttcttcctg aggtctgagc accctccaaa ctgagtccag atctgagttt     60

ttcctcggag atttgtcaga atgagcctcc aggccccatc cagactgctg gagctggcag    120

ggcagagcct gctgaggaac cagttcttga ccatcttcac cctggatgag ctgcccaggg    180

aggtcttccc tctgatgttc atggaggcct tcagcatgag acgttttgag gccctgaagc    240

tgatggtgca ggcctggccc ttcctcagcc tccctctggg atccctgatg aagacacttc    300

atctggagac cttgcaagct gtcctgaggg gacttgatac actggtggcc cagaaggttc    360

gccccaggag gtggaaactt caagtgctgg atttgcggga tgttgatgag aatttctgga    420

ccatatggtc tggagccagg gtcctctcct gctccccaga ggccatgagt aagaggcaga    480

cagtggagga ctgtccaagg atgggagagc accagccctt gaaggtgttc atagacctct    540

gcctaaagga aagtacactg gatgaatgcc tgagctacct ttttgggtgg atccactaca    600

gaagaggcct agtgcacctg tgttgtagta aggtgcagaa ttactcaatg cccacttcaa    660

gtttcagaaa tctattggaa aggatatacc cagacagtat ccaggagttg gaagtctgga    720

aaaagtgctc tctcaataaa acgggaaagt ttgcccctta cctgagccag atgagcaatc    780

ttcgtgaact ctttttagcc ttcggttatg agcgtgagtt gtacgtgagc gtccagtggc    840

cgtgcattcc tgacttggac tctccattcc tctgcctgta ctacccccag atgctttata    900

taaaaaagat cagtaatatc aaagagcacc tggagcacct gctcaggtac ctcaagaacc    960

ccttgggggc ctttatattc agtgatgctt acctaactga tcgggacatg gagtgtctgt   1020

ctcagtaccc aagcctcagt cagctaaagg agctgcgtct gattcatatc ctaatgtgga   1080

ccacccatct tgagcccctt ggagttctgc tggagaaagt tgctgctact ctcaagaccc   1140

tcgtcttaaa ggactgtcgg atccaggacc cccaactcag ggtcctcctg cctgccctga   1200

gccactgttc ccagctcacc accttcaact ttcatggaaa tgagacctcc atgaatgctc   1260

tgaaagacct gctgcgtcac acaggcgggc tgagcaagtt aggcctggag ttgtatcctg   1320

cccctctgga gagtcttgac tacaagggtc atgtcaattg ggagatcctc accccaattc   1380

gggctgagct gatgcgtaca ctcagggaag tcaggcagcc caagaggatc ttctttggtc   1440

ccgtcccttg ccctaactgt ggctcatggc catctgagaa agtggacttc catctttgct   1500

cctagggaag gcctggttcg tggga                                         1525


<210>  1480
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  1480

Met Ser Leu Gln Ala Pro Ser Arg Leu Leu Glu Leu Ala Gly Gln Ser 
1               5                   10                  15


Leu Leu Arg Asn Gln Phe Leu Thr Ile Phe Thr Leu Asp Glu Leu Pro 
            20                  25                  30


Arg Glu Val Phe Pro Leu Met Phe Met Glu Ala Phe Ser Met Arg Arg 
        35                  40                  45


Phe Glu Ala Leu Lys Leu Met Val Gln Ala Trp Pro Phe Leu Ser Leu 
    50                  55                  60


Pro Leu Gly Ser Leu Met Lys Thr Leu His Leu Glu Thr Leu Gln Ala 
65                  70                  75                  80


Val Leu Arg Gly Leu Asp Thr Leu Val Ala Gln Lys Val Arg Pro Arg 
                85                  90                  95


Arg Trp Lys Leu Gln Val Leu Asp Leu Arg Asp Val Asp Glu Asn Phe 
            100                 105                 110


Trp Thr Ile Trp Ser Gly Ala Arg Val Leu Ser Cys Ser Pro Glu Ala 
        115                 120                 125


Met Ser Lys Arg Gln Thr Val Glu Asp Cys Pro Arg Met Gly Glu His 
    130                 135                 140


Gln Pro Leu Lys Val Phe Ile Asp Leu Cys Leu Lys Glu Ser Thr Leu 
145                 150                 155                 160


Asp Glu Cys Leu Ser Tyr Leu Phe Gly Trp Ile His Tyr Arg Arg Gly 
                165                 170                 175


Leu Val His Leu Cys Cys Ser Lys Val Gln Asn Tyr Ser Met Pro Thr 
            180                 185                 190


Ser Ser Phe Arg Asn Leu Leu Glu Arg Ile Tyr Pro Asp Ser Ile Gln 
        195                 200                 205


Glu Leu Glu Val Trp Lys Lys Cys Ser Leu Asn Lys Thr Gly Lys Phe 
    210                 215                 220


Ala Pro Tyr Leu Ser Gln Met Ser Asn Leu Arg Glu Leu Phe Leu Ala 
225                 230                 235                 240


Phe Gly Tyr Glu Arg Glu Leu Tyr Val Ser Val Gln Trp Pro Cys Ile 
                245                 250                 255


Pro Asp Leu Asp Ser Pro Phe Leu Cys Leu Tyr Tyr Pro Gln Met Leu 
            260                 265                 270


Tyr Ile Lys Lys Ile Ser Asn Ile Lys Glu His Leu Glu His Leu Leu 
        275                 280                 285


Arg Tyr Leu Lys Asn Pro Leu Gly Ala Phe Ile Phe Ser Asp Ala Tyr 
    290                 295                 300


Leu Thr Asp Arg Asp Met Glu Cys Leu Ser Gln Tyr Pro Ser Leu Ser 
305                 310                 315                 320


Gln Leu Lys Glu Leu Arg Leu Ile His Ile Leu Met Trp Thr Thr His 
                325                 330                 335


Leu Glu Pro Leu Gly Val Leu Leu Glu Lys Val Ala Ala Thr Leu Lys 
            340                 345                 350


Thr Leu Val Leu Lys Asp Cys Arg Ile Gln Asp Pro Gln Leu Arg Val 
        355                 360                 365


Leu Leu Pro Ala Leu Ser His Cys Ser Gln Leu Thr Thr Phe Asn Phe 
    370                 375                 380


His Gly Asn Glu Thr Ser Met Asn Ala Leu Lys Asp Leu Leu Arg His 
385                 390                 395                 400


Thr Gly Gly Leu Ser Lys Leu Gly Leu Glu Leu Tyr Pro Ala Pro Leu 
                405                 410                 415


Glu Ser Leu Asp Tyr Lys Gly His Val Asn Trp Glu Ile Leu Thr Pro 
            420                 425                 430


Ile Arg Ala Glu Leu Met Arg Thr Leu Arg Glu Val Arg Gln Pro Lys 
        435                 440                 445


Arg Ile Phe Phe Gly Pro Val Pro Cys Pro Asn Cys Gly Ser Trp Pro 
    450                 455                 460


Ser Glu Lys Val Asp Phe His Leu Cys Ser 
465                 470


<210>  1481
<211>  1425
<212>  DNA
<213>  Homo sapiens

<400>  1481
atgagcatca gggccccacc cagactcctg gagctggcaa ggcagaggct gctgagggac     60

caggccttgg ccatctccac catggaggag ctgcccaggg agctcttccc cacactgttc    120

atggaggcct tcagcaggag acgctgtgaa accctgaaaa caatggtgca ggcctggcct    180

ttcacccgcc tccctctagg gtccctgatg aagtcgcctc atctggagtc attaaaatct    240

gtgctggaag gggttgatgt gctgttgacc caagaggttc gccccaggca gtcaaaactt    300

caagtgctgg acttgaggaa tgtggatgag aacttctgcg acatattttc tggagctact    360

gcatccttcc cggaggctct gagtcagaag caaacagcag ataactgtcc agggacaggc    420

aggcagcagc cattcatggt gttcatagac ctttgtctca agaacaggac actagatgaa    480

tgcctcaccc acctcttaga gtggggcaag cagagaaaag gcttactgca tgtgtgttgc    540

aaggagctgc aggtttttgg aatgcccatc cacagtatca tagaggtcct gaacatggtg    600

gagcttgact gtatccagga ggtggaagtg tgctgcccct gggagctgtc cactcttgtg    660

aagtttgccc cttacctggg ccagatgagg aatctccgca aacttgttct cttcaacatc    720

cgtgcatctg cctgcattcc cccagacaac aaggggcagt tcattgcccg attcacctct    780

cagttcctca agctggacta tttccagaat ctgtctatgc actccgtctc tttcctcgaa    840

ggccacctgg accagctgct caggtgtctc caggcctcct tggagatggt cgttatgacc    900

gactgcctgc tgtcagagtc ggacttgaag catctctctt ggtgcccgag catccgtcaa    960

ttaaaggagc tggacctgag gggtgtcacg ctgacccatt tcagccctga gcccctcaca   1020

ggtctgctgg agcaagttgt ggccaccctg cagaccctgg acttagagga ctgtgggatc   1080

atggattccc aactcagcgc catcctgcct gtcctgagcc gctgctccca gctcagcacc   1140

ttcagcttct gtgggaacct catctccatg gctgcccttg agaacctgct gcgccacacc   1200

gtcgggctga gcaagctaag cctggagctg tatcctgccc ctctggagag ttatgacacc   1260

cagggtgctc tctgctgggg gagatttgct gaacttgggg ctgagctgat gaagacaccg   1320

agggacttaa ggcagcccaa gatcattgtg ttctgcaccg tcccctgccc tcgctgtggc   1380

atcagggcct cctatgacct ggagcccagt cactgcctct gttga                   1425


<210>  1482
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  1482

Met Ser Ile Arg Ala Pro Pro Arg Leu Leu Glu Leu Ala Arg Gln Arg 
1               5                   10                  15


Leu Leu Arg Asp Gln Ala Leu Ala Ile Ser Thr Met Glu Glu Leu Pro 
            20                  25                  30


Arg Glu Leu Phe Pro Thr Leu Phe Met Glu Ala Phe Ser Arg Arg Arg 
        35                  40                  45


Cys Glu Thr Leu Lys Thr Met Val Gln Ala Trp Pro Phe Thr Arg Leu 
    50                  55                  60


Pro Leu Gly Ser Leu Met Lys Ser Pro His Leu Glu Ser Leu Lys Ser 
65                  70                  75                  80


Val Leu Glu Gly Val Asp Val Leu Leu Thr Gln Glu Val Arg Pro Arg 
                85                  90                  95


Gln Ser Lys Leu Gln Val Leu Asp Leu Arg Asn Val Asp Glu Asn Phe 
            100                 105                 110


Cys Asp Ile Phe Ser Gly Ala Thr Ala Ser Phe Pro Glu Ala Leu Ser 
        115                 120                 125


Gln Lys Gln Thr Ala Asp Asn Cys Pro Gly Thr Gly Arg Gln Gln Pro 
    130                 135                 140


Phe Met Val Phe Ile Asp Leu Cys Leu Lys Asn Arg Thr Leu Asp Glu 
145                 150                 155                 160


Cys Leu Thr His Leu Leu Glu Trp Gly Lys Gln Arg Lys Gly Leu Leu 
                165                 170                 175


His Val Cys Cys Lys Glu Leu Gln Val Phe Gly Met Pro Ile His Ser 
            180                 185                 190


Ile Ile Glu Val Leu Asn Met Val Glu Leu Asp Cys Ile Gln Glu Val 
        195                 200                 205


Glu Val Cys Cys Pro Trp Glu Leu Ser Thr Leu Val Lys Phe Ala Pro 
    210                 215                 220


Tyr Leu Gly Gln Met Arg Asn Leu Arg Lys Leu Val Leu Phe Asn Ile 
225                 230                 235                 240


Arg Ala Ser Ala Cys Ile Pro Pro Asp Asn Lys Gly Gln Phe Ile Ala 
                245                 250                 255


Arg Phe Thr Ser Gln Phe Leu Lys Leu Asp Tyr Phe Gln Asn Leu Ser 
            260                 265                 270


Met His Ser Val Ser Phe Leu Glu Gly His Leu Asp Gln Leu Leu Arg 
        275                 280                 285


Cys Leu Gln Ala Ser Leu Glu Met Val Val Met Thr Asp Cys Leu Leu 
    290                 295                 300


Ser Glu Ser Asp Leu Lys His Leu Ser Trp Cys Pro Ser Ile Arg Gln 
305                 310                 315                 320


Leu Lys Glu Leu Asp Leu Arg Gly Val Thr Leu Thr His Phe Ser Pro 
                325                 330                 335


Glu Pro Leu Thr Gly Leu Leu Glu Gln Val Val Ala Thr Leu Gln Thr 
            340                 345                 350


Leu Asp Leu Glu Asp Cys Gly Ile Met Asp Ser Gln Leu Ser Ala Ile 
        355                 360                 365


Leu Pro Val Leu Ser Arg Cys Ser Gln Leu Ser Thr Phe Ser Phe Cys 
    370                 375                 380


Gly Asn Leu Ile Ser Met Ala Ala Leu Glu Asn Leu Leu Arg His Thr 
385                 390                 395                 400


Val Gly Leu Ser Lys Leu Ser Leu Glu Leu Tyr Pro Ala Pro Leu Glu 
                405                 410                 415


Ser Tyr Asp Thr Gln Gly Ala Leu Cys Trp Gly Arg Phe Ala Glu Leu 
            420                 425                 430


Gly Ala Glu Leu Met Lys Thr Pro Arg Asp Leu Arg Gln Pro Lys Ile 
        435                 440                 445


Ile Val Phe Cys Thr Val Pro Cys Pro Arg Cys Gly Ile Arg Ala Ser 
    450                 455                 460


Tyr Asp Leu Glu Pro Ser His Cys Leu Cys 
465                 470


<210>  1483
<211>  951
<212>  DNA
<213>  Homo sapiens

<400>  1483
atggtgctgg tgaggaagct caaggaggct ttggccgttg tccagatcct cagagaaagg     60

actgctcacc atacagggtc cactgtggga acagaaacct gctttttccc agtggaagag    120

gccatgagta agaggcagac agcagaggac tatccaagga tgggagagca ccagccctta    180

aaggtgttca tagacgtctg cctcaaggaa acaccccaag atgaatgcct gagatacctc    240

ttccagctgg aacacctcca attgcttaaa gtaaaattga tcaccttctt cagtgggcac    300

ctggaacagc tgatcaggtg cctccagaac cccttggaga acttggagtt aacttgtggc    360

tacctattgg aagaggacat gaagtgtctg tctcagtacc caagcctcag ctacctaaag    420

catctgaatc tcagctacgt gctgctgttc cgcatcagtc ttgaacccct cggagctctg    480

ctagagaaaa ttgctgccac tctcaagacc ctcatcttcg agggctgtca gatccactac    540

tgccaactca gcgccatcct gcctggcctg agccgctgct cccagctcac caccttctac    600

tttggcagaa attgcatgtc tacggacacc ctgaaggacc tgctgcgcca caccagtggg    660

ctgagcaagt taagcctgga gacgtatcct gcccctgagg agagtttgaa ttccttggtt    720

cgtgtcgatt gggagatctt cgccccactt cgggctgagc tgatgtgtac actgagggaa    780

gtcaggcagc ccaagaggat cttcactggt cccactccct gcccttcctg tggctcatca    840

ccgtctgagg aactggagct ccatctttgc tgctagggaa ggcgtgccta gtggggttga    900

taaatccaaa gttctcttcc aggcacttgg acactaaaat ctagtatgta a             951


<210>  1484
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  1484

Met Val Leu Val Arg Lys Leu Lys Glu Ala Leu Ala Val Val Gln Ile 
1               5                   10                  15


Leu Arg Glu Arg Thr Ala His His Thr Gly Ser Thr Val Gly Thr Glu 
            20                  25                  30


Thr Cys Phe Phe Pro Val Glu Glu Ala Met Ser Lys Arg Gln Thr Ala 
        35                  40                  45


Glu Asp Tyr Pro Arg Met Gly Glu His Gln Pro Leu Lys Val Phe Ile 
    50                  55                  60


Asp Val Cys Leu Lys Glu Thr Pro Gln Asp Glu Cys Leu Arg Tyr Leu 
65                  70                  75                  80


Phe Gln Leu Glu His Leu Gln Leu Leu Lys Val Lys Leu Ile Thr Phe 
                85                  90                  95


Phe Ser Gly His Leu Glu Gln Leu Ile Arg Cys Leu Gln Asn Pro Leu 
            100                 105                 110


Glu Asn Leu Glu Leu Thr Cys Gly Tyr Leu Leu Glu Glu Asp Met Lys 
        115                 120                 125


Cys Leu Ser Gln Tyr Pro Ser Leu Ser Tyr Leu Lys His Leu Asn Leu 
    130                 135                 140


Ser Tyr Val Leu Leu Phe Arg Ile Ser Leu Glu Pro Leu Gly Ala Leu 
145                 150                 155                 160


Leu Glu Lys Ile Ala Ala Thr Leu Lys Thr Leu Ile Phe Glu Gly Cys 
                165                 170                 175


Gln Ile His Tyr Cys Gln Leu Ser Ala Ile Leu Pro Gly Leu Ser Arg 
            180                 185                 190


Cys Ser Gln Leu Thr Thr Phe Tyr Phe Gly Arg Asn Cys Met Ser Thr 
        195                 200                 205


Asp Thr Leu Lys Asp Leu Leu Arg His Thr Ser Gly Leu Ser Lys Leu 
    210                 215                 220


Ser Leu Glu Thr Tyr Pro Ala Pro Glu Glu Ser Leu Asn Ser Leu Val 
225                 230                 235                 240


Arg Val Asp Trp Glu Ile Phe Ala Pro Leu Arg Ala Glu Leu Met Cys 
                245                 250                 255


Thr Leu Arg Glu Val Arg Gln Pro Lys Arg Ile Phe Thr Gly Pro Thr 
            260                 265                 270


Pro Cys Pro Ser Cys Gly Ser Ser Pro Ser Glu Glu Leu Glu Leu His 
        275                 280                 285


Leu Cys Cys 
    290


<210>  1485
<211>  1720
<212>  DNA
<213>  Homo sapiens

<400>  1485
aggtccccaa agtcccatcg aatccatggc aacacttccc ccaagtcctg cccctgcttg     60

atcaccttcc ctttcccact ttcagagccc atgtgtgaaa tgatgggttc tgtgctccct    120

ataggatgta cctaagacct aggttttagt ttccaagtgt ccagaagaaa gcgtttgaca    180

tatccaccca aataggcagg cattcaacag cagcattgat ctgcctccag gtcataaaat    240

gacctgttgc cacagtcagg gcagcagtca gtacagaaca agatcctctt ggggtgcctt    300

aagtccctca ctctcttcat cagctcagcc ctaatttgag caaatctgct ccagcagaga    360

gtaccatcag catcataact ctcccggggg gcaggataca gctccacgca taagtttttg    420

agtatgattg tgtggctcag caggttctcc agggtggcca tggagatggg atttccacag    480

aagctgaagg tgttgagctc aaagcagcgg ctcagggcag gcaggatggc gttgacttgg    540

gagtctatga tgccacagtc atctaaatcc aggtactcaa gggtggctgc aactttttct    600

aggagaattt ggagaggcac aagactgtaa ttggtcagtc tgatgccact caggtccagg    660

gtctttagtt gactgatact cgggcactgg gatagatgct tcaagtctga ttccaaaagc    720

acacagttag ttattgtgag gacctttaac gaggtcttca gacagctgag cagctggtcc    780

aggtggcctt cgaggaaaga aacagagttc atagaaagct tttggaggca gcacagcttg    840

aggaactgag tggtgaactg ggtaacaatc tccttcttct gctctgggga aacgtagcga    900

gagacatcca tgtgggagag aacgagcttc tgaagattcc tcatgtggcc caggtatggg    960

gtaaactgtg tcaggatggg cagtacccac ttgcaattca cttccacctc ctggatacag   1020

tctaggttca ccattttcag gatgcttctg atattgcgga agggcattcc caaaattttc   1080

agcttcttac agcacaggtg tagtaaatct ttcctctgct tgacccatag aaggaggcag   1140

gtgaggtatt catccagagt cctgttcttg agccaaagtt ctacgaacac agtcaagggc   1200

tgctgtcctc tcatccttgg acagtcctgc actggtgttt tgttcctctt ggcattgagg   1260

aagcacccac gggccatagc ttcagaccaa accatccaga agttctcaca gacatcctgt   1320

aaatccagca cttgaagttt ccacctcctg ggatgaaccc cttgggtaag cagtgcatcc   1380

agcccatcga gcacagcttg gaaggcctcc agacaaggca tctttatcag aggcctcaga   1440

gggaggcggc ggaagggcca ggcctgcacc atcagcttca gggcctcaca gcgtctcctg   1500

ctgaaggcct ccatgaacag tggggggaaa agttctgtgg gcagctcctc cagggtggac   1560

atggccaagg cttggtccct cagcaggctc cgccctgcaa gctccaggag tctgggtgga   1620

gtccggatgc tcatcttcac gaatctgcag ggaaaacaga tctggatgta gtctagaagg   1680

tgctcagtcc tcaggaagaa ccaagcagga actccaggct                         1720


<210>  1486
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  1486

Met Asn Pro Leu Gly Lys Gln Cys Ile Gln Pro Ile Glu His Ser Leu 
1               5                   10                  15


Glu Gly Leu Gln Thr Arg His Leu Tyr Gln Arg Pro Gln Arg Glu Ala 
            20                  25                  30


Ala Glu Gly Pro Gly Leu His His Gln Leu Gln Gly Leu Thr Ala Ser 
        35                  40                  45


Pro Ala Glu Gly Leu His Glu Gln Trp Gly Glu Lys Phe Cys Gly Gln 
    50                  55                  60


Leu Leu Gln Gly Gly His Gly Gln Gly Leu Val Pro Gln Gln Ala Pro 
65                  70                  75                  80


Pro Cys Lys Leu Gln Glu Ser Gly Trp Ser Pro Asp Ala His Leu His 
                85                  90                  95


Glu Ser Ala Gly Lys Thr Asp Leu Asp Val Val 
            100                 105


<210>  1487
<211>  390
<212>  DNA
<213>  Homo sapiens

<400>  1487
atggaggccg tcagcaggag acgctgtgag gccctgaagc tgatggtgca ggcctggtcc     60

ttcctccacc tccctctggg atccctgatg aagacacctc atctggagac cttgcaagct    120

gtgctgaagg gacttgatac actgctggcc cagaaggttt gcctcaggag gtggaaactt    180

caagtgctgg atttgcggga tgttgatggg aatttctgga ccatatggtc tggagccaag    240

gtcctctcct gctccccaga ggccatgagt aaaaggcaga cagtggagga ctgtccaagg    300

atgggagagt gccagccctt gaaggtgttc atagaccgct gcctaaagaa aagtacactg    360

gatgaatgcc tgagctacct ttgtgggtag                                     390


<210>  1488
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  1488

Met Glu Ala Val Ser Arg Arg Arg Cys Glu Ala Leu Lys Leu Met Val 
1               5                   10                  15


Gln Ala Trp Ser Phe Leu His Leu Pro Leu Gly Ser Leu Met Lys Thr 
            20                  25                  30


Pro His Leu Glu Thr Leu Gln Ala Val Leu Lys Gly Leu Asp Thr Leu 
        35                  40                  45


Leu Ala Gln Lys Val Cys Leu Arg Arg Trp Lys Leu Gln Val Leu Asp 
    50                  55                  60


Leu Arg Asp Val Asp Gly Asn Phe Trp Thr Ile Trp Ser Gly Ala Lys 
65                  70                  75                  80


Val Leu Ser Cys Ser Pro Glu Ala Met Ser Lys Arg Gln Thr Val Glu 
                85                  90                  95


Asp Cys Pro Arg Met Gly Glu Cys Gln Pro Leu Lys Val Phe Ile Asp 
            100                 105                 110


Arg Cys Leu Lys Lys Ser Thr Leu Asp Glu Cys Leu Ser Tyr Leu Cys 
        115                 120                 125


Gly 



<210>  1489
<211>  2081
<212>  DNA
<213>  Homo sapiens

<400>  1489
cttgcagatt tatgaggatg agcctacagg ccccacgcag actcctggag ctggcagggc     60

agagcctgct gggggaccag gccttggcca tctccatctt ggatgagctg cccagggagc    120

tcttcccccc actgttcgtg gaggccttca ctagcagacg ctgcgaggtt ctgaaggtga    180

tggtgcaggc ctggcccttc ccctgcctcc ctctggggtc cctgatgaag acgcctgatc    240

tggagatctt acattatgta gtggatggga ttgattgcct gcttgcccaa aaggttcgcc    300

ccaggaggtg gaaacttcaa gtgctggaat tgcgggatgt tgatgagaat ttttggacca    360

tatggtctgg agccaggccc ctgtcctgct ccccagaggc catgagtaag aggcagacag    420

tggaggactg tccaaggaca ggagagaagc agcccttgaa ggtgttcatg gatgtttgcc    480

tcaaggaaaa attcatggat gaagatctga gcttcttctc tgggtgggtc cagcacagaa    540

gaggttcagt acacctgtgc tgtactaagg tggtgaatta ttcaatgagc attctaaatt    600

tcagaaacat attggaaaca gtatacccag acagtatcca agtgttggaa atttggaaca    660

tgtgctggcc gtgtatgata gtagagttta gccgttacct gagccagatg aggaatcttc    720

gcaaactctt catctccgat ggctgtcgtt acctgctaag ctctgacagc caagaacagt    780

tagttgctga attcagctct gtgctcctca ggctggagta cctccagatg ctttatgtaa    840

gaagggtctg cttcttcaga ggccacctgg accagctgat caggtgcctc aggagcccat    900

tggagacatt ggcattaact tatggcttcc tagaaaaagt ggacttgaaa tgtctgcccc    960

ggtacccaag tctcagtcaa ctgaagcagc tgaatctgag tcatggtgca ctgcgcttca   1020

tccgtcttga gcccctccga gctctgctag agaaagttgc tgccactctt cagaccctct   1080

tcttagtgga ctgtgggatt cgggactcca aactcagggt catcctgcct gccctgagct   1140

gctgctccaa cctcaccact ttctgttttc acggcaatga cacgtccatg gatggtctga   1200

aggacctgct gcgccacaca ggcaggctga gcaatttgag cctggaaaca tatcctgccc   1260

ctcgggagag tcttgatgac aggggtcgtg tcatttcgga gctcctcacc ccacttcagg   1320

ctgagctgat gcgtatactg agggaagtaa gggagcccaa aaggatcttc tttggtccgg   1380

tgtcctgccc ttgctgtggc acgtcgccca ctgagcaact ggagttcaat ttttgcttgt   1440

ggggaaggcc tgcctagtgg ggtggaggta taaaaagctt tttctccagg cacttggaaa   1500

ctaaaatctg ggacatagat gtcttttatt tttctttttc cttattttac aattttacag   1560

tttttattta aaaatttgag acagggtttc cctatgttgt ccaggctggt ctcaaactct   1620

tacgcttaag ggagccacct gcttggcctc ccaagattct gggattacag gcataagcag   1680

ctgtgccggg tctataggtg cattataaag ggaacagaga aacctctgtt tcaggcatgt   1740

gctttctgtg agtggaaaac aaaaaatccc agcagggggc agcactgggg aaaaagttga   1800

atggagtcac tgagactcag ggatctgtgt cctagacagt cagaaataga aagctgaagt   1860

tctagagtga aggagttatc tcagcaagga tggatacaaa gaaacgtcgg aagtagaggg   1920

aacctaaatg gaaactctct gctgtccttc atgattgatt agcctgtttc agcaatttat   1980

acatcagaaa tctttagttc ctgatgaatt aaaaaaagag gtactagttc atctgtgatt   2040

taggttcatc tgcaggaaat aaaggaatca aaataaactt c                       2081


<210>  1490
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  1490

Met Arg Met Ser Leu Gln Ala Pro Arg Arg Leu Leu Glu Leu Ala Gly 
1               5                   10                  15


Gln Ser Leu Leu Gly Asp Gln Ala Leu Ala Ile Ser Ile Leu Asp Glu 
            20                  25                  30


Leu Pro Arg Glu Leu Phe Pro Pro Leu Phe Val Glu Ala Phe Thr Ser 
        35                  40                  45


Arg Arg Cys Glu Val Leu Lys Val Met Val Gln Ala Trp Pro Phe Pro 
    50                  55                  60


Cys Leu Pro Leu Gly Ser Leu Met Lys Thr Pro Asp Leu Glu Ile Leu 
65                  70                  75                  80


His Tyr Val Val Asp Gly Ile Asp Cys Leu Leu Ala Gln Lys Val Arg 
                85                  90                  95


Pro Arg Arg Trp Lys Leu Gln Val Leu Glu Leu Arg Asp Val Asp Glu 
            100                 105                 110


Asn Phe Trp Thr Ile Trp Ser Gly Ala Arg Pro Leu Ser Cys Ser Pro 
        115                 120                 125


Glu Ala Met Ser Lys Arg Gln Thr Val Glu Asp Cys Pro Arg Thr Gly 
    130                 135                 140


Glu Lys Gln Pro Leu Lys Val Phe Met Asp Val Cys Leu Lys Glu Lys 
145                 150                 155                 160


Phe Met Asp Glu Asp Leu Ser Phe Phe Ser Gly Trp Val Gln His Arg 
                165                 170                 175


Arg Gly Ser Val His Leu Cys Cys Thr Lys Val Val Asn Tyr Ser Met 
            180                 185                 190


Ser Ile Leu Asn Phe Arg Asn Ile Leu Glu Thr Val Tyr Pro Asp Ser 
        195                 200                 205


Ile Gln Val Leu Glu Ile Trp Asn Met Cys Trp Pro Cys Met Ile Val 
    210                 215                 220


Glu Phe Ser Arg Tyr Leu Ser Gln Met Arg Asn Leu Arg Lys Leu Phe 
225                 230                 235                 240


Ile Ser Asp Gly Cys Arg Tyr Leu Leu Ser Ser Asp Ser Gln Glu Gln 
                245                 250                 255


Leu Val Ala Glu Phe Ser Ser Val Leu Leu Arg Leu Glu Tyr Leu Gln 
            260                 265                 270


Met Leu Tyr Val Arg Arg Val Cys Phe Phe Arg Gly His Leu Asp Gln 
        275                 280                 285


Leu Ile Arg Cys Leu Arg Ser Pro Leu Glu Thr Leu Ala Leu Thr Tyr 
    290                 295                 300


Gly Phe Leu Glu Lys Val Asp Leu Lys Cys Leu Pro Arg Tyr Pro Ser 
305                 310                 315                 320


Leu Ser Gln Leu Lys Gln Leu Asn Leu Ser His Gly Ala Leu Arg Phe 
                325                 330                 335


Ile Arg Leu Glu Pro Leu Arg Ala Leu Leu Glu Lys Val Ala Ala Thr 
            340                 345                 350


Leu Gln Thr Leu Phe Leu Val Asp Cys Gly Ile Arg Asp Ser Lys Leu 
        355                 360                 365


Arg Val Ile Leu Pro Ala Leu Ser Cys Cys Ser Asn Leu Thr Thr Phe 
    370                 375                 380


Cys Phe His Gly Asn Asp Thr Ser Met Asp Gly Leu Lys Asp Leu Leu 
385                 390                 395                 400


Arg His Thr Gly Arg Leu Ser Asn Leu Ser Leu Glu Thr Tyr Pro Ala 
                405                 410                 415


Pro Arg Glu Ser Leu Asp Asp Arg Gly Arg Val Ile Ser Glu Leu Leu 
            420                 425                 430


Thr Pro Leu Gln Ala Glu Leu Met Arg Ile Leu Arg Glu Val Arg Glu 
        435                 440                 445


Pro Lys Arg Ile Phe Phe Gly Pro Val Ser Cys Pro Cys Cys Gly Thr 
    450                 455                 460


Ser Pro Thr Glu Gln Leu Glu Phe Asn Phe Cys Leu Trp Gly Arg Pro 
465                 470                 475                 480


Ala 



<210>  1491
<211>  2814
<212>  DNA
<213>  Homo sapiens

<400>  1491
atgagcctcc agtccccatc cagactcctg gagctggcag ggcagagcct gctgaggaac     60

cagttcttga ccatcttcat cctggacgag ctgcccaggg aggtcttccc tctgatgttc    120

atggaggccg tcagcaggag acgctgtgag gccctgaagc tgatggtgca ggcctggtcc    180

ttcctccacc tccctctggg atccctgatg aagacacctc atctggagac cttgcaagct    240

gtgctgaagg gacttgatac actgctggcc cagaaggttt gcctcaggag gtggaaactt    300

caagtgctgg atttgcggga tgttgatggg aatttctgga ccatatggtc tggagccaag    360

gtcctctcct gctccccaga ggccatgagt aaaagacaga cagtggagga ctgtccaagg    420

atgggagagt gccagccctt gaaggtgttc atagaccgct gcctaaagaa aagtatgctg    480

gatgaatgcc tgagctacct ttgtgggtgc ctcaagaacc tcttgggggc ctttatattc    540

tgtcatgctt acctagctga tcgggacatg gagtgtctgt ctcagtaccc aagcctcagt    600

cagctaaagg agctgcatct gattcatatc ctaatgtgga ccaccaatct tgagcccctt    660

ggagctctgc tagagaaagt tgctgctact cttgagaccc tcacgttaaa ggactgtcag    720

atccaggact cccaactcag ggtcctcctg cctgccctga gccactgctc ccagctcacc    780

accttctact ttcaaggaaa cgagacttcc atgaatgctc tgaaagacct tctgtgtcac    840

acaggcgggc tgagcaagtt aggtctggag ttgtatcctt cccgtctgga gagtcttgac    900

aacaggggtc atgccaattg ggagatcctt gccccaattc gggctgagct gatgtgtaca    960

ctcagggaag agagacccaa agtcttcaag cctagagttc ctgcttggtt cttcctgagg   1020

actgagcacc ttctagacta catccagatc tgttttccct gcagattcgt gaagatgagc   1080

atccggactc cacccagact cctggagctt gcagggcgga gcctgctgag ggaccaagcc   1140

ttggccatgt ccaccctgga ggagctgccc acagaacttt tccccccact gttcatggag   1200

gccttcagca ggagacgctg tgaggccctg aagctgatgg tgcaggcctg gcccttccgc   1260

cgcctccctc tgaggcctct gataaagatg ccttgtctgg aggccttcca agctgtgctc   1320

gatgggctgg atgcactgct tacccaaggg gttcatccca ggaggtggaa acttcaagtg   1380

ctggatttac aggatgtctg tgagaacttc tggatggttt ggtctgaagc tatggcccat   1440

gggtgcttcc tcaatgccaa gaggaacaaa aaaccagtgc aggactgtcc aaggatgaga   1500

ggacagcagc ccttgactgt gttcgtagaa ctttggctca agaacaggac tctggatgaa   1560

tacctcacct gcctccttct atgggtcaag cagaggaaag atttactaca cctgtgctgt   1620

aagaagctga aaattttggg aatgcccttc cgcaatatca gaagcatcct gaaaatggtg   1680

aacctagact gtatccagga ggtggaagtg aattgcaagt gggtactgcc catcctgaca   1740

cagtttaccc catacctggg ccacatgagg aatcttcaga agctcgttct ctcccacatg   1800

gatgtctctc gctacgtttc cccagagcag aagaaggaga ttgttaccca gttcaccact   1860

cagttcctca agctgtgctg cctccaaaag ctttctatga actctgtttc tttcctcgaa   1920

ggccacctgg accagctgct cagctgtctg aagacctcgt taaaggtcct cacaataact   1980

aactgtgtgc ttttggaatc agacttgaag catctatccc agtgcccgag tatcagtcaa   2040

ctaaagaccc tggacctgag tggcatcaga ctgaccaatt acagtcttgt gcctctccaa   2100

attctcctag aaaaagttgc agccaccctt gagtacctgg atttagatga ctgtggcatc   2160

atagactccc aagtcaacgc catcctgcct gccctgagct gctgctttga gctcaacacc   2220

ttcagcttct gtggaaatcc catctccatg gccaccctgg agaacctgct gagccacaca   2280

atcatactca aaaacttatg cgtggagctg tatcctgccc cccgggagag ttatgatgct   2340

gatggtactc tctgctggag cagatttcct caaattaggg ctgagctgat gaagagagtg   2400

agggacttaa ggcaccccaa gaggatcttg ttctgtactg actgctgccc tgactgtggc   2460

aacaggtcat tttatgacct ggaggcagat caatgctgct gttgaatgcc tgcctatttg   2520

ggtggatatg tcaaacgctt tcttctggac acttggaaac taaaacctag gtcttaggta   2580

catcctatag ggagcacaga acccatcatt tcacacatgg gctctgaaag tgggaaagga   2640

aaggtgatca agcaggggca ggacttgggg gaagtgttgc catggattcg atgggacttt   2700

ggggacctgt gtcctgtaga gtggaaaatg ggaatttgaa tgtctagagt ggaggcttga   2760

gaatacttga gggagttact cttggatgca tggttgtaaa gaaacaatca gaaa         2814


<210>  1492
<211>  834
<212>  PRT
<213>  Homo sapiens

<400>  1492

Met Ser Leu Gln Ser Pro Ser Arg Leu Leu Glu Leu Ala Gly Gln Ser 
1               5                   10                  15


Leu Leu Arg Asn Gln Phe Leu Thr Ile Phe Ile Leu Asp Glu Leu Pro 
            20                  25                  30


Arg Glu Val Phe Pro Leu Met Phe Met Glu Ala Val Ser Arg Arg Arg 
        35                  40                  45


Cys Glu Ala Leu Lys Leu Met Val Gln Ala Trp Ser Phe Leu His Leu 
    50                  55                  60


Pro Leu Gly Ser Leu Met Lys Thr Pro His Leu Glu Thr Leu Gln Ala 
65                  70                  75                  80


Val Leu Lys Gly Leu Asp Thr Leu Leu Ala Gln Lys Val Cys Leu Arg 
                85                  90                  95


Arg Trp Lys Leu Gln Val Leu Asp Leu Arg Asp Val Asp Gly Asn Phe 
            100                 105                 110


Trp Thr Ile Trp Ser Gly Ala Lys Val Leu Ser Cys Ser Pro Glu Ala 
        115                 120                 125


Met Ser Lys Arg Gln Thr Val Glu Asp Cys Pro Arg Met Gly Glu Cys 
    130                 135                 140


Gln Pro Leu Lys Val Phe Ile Asp Arg Cys Leu Lys Lys Ser Met Leu 
145                 150                 155                 160


Asp Glu Cys Leu Ser Tyr Leu Cys Gly Cys Leu Lys Asn Leu Leu Gly 
                165                 170                 175


Ala Phe Ile Phe Cys His Ala Tyr Leu Ala Asp Arg Asp Met Glu Cys 
            180                 185                 190


Leu Ser Gln Tyr Pro Ser Leu Ser Gln Leu Lys Glu Leu His Leu Ile 
        195                 200                 205


His Ile Leu Met Trp Thr Thr Asn Leu Glu Pro Leu Gly Ala Leu Leu 
    210                 215                 220


Glu Lys Val Ala Ala Thr Leu Glu Thr Leu Thr Leu Lys Asp Cys Gln 
225                 230                 235                 240


Ile Gln Asp Ser Gln Leu Arg Val Leu Leu Pro Ala Leu Ser His Cys 
                245                 250                 255


Ser Gln Leu Thr Thr Phe Tyr Phe Gln Gly Asn Glu Thr Ser Met Asn 
            260                 265                 270


Ala Leu Lys Asp Leu Leu Cys His Thr Gly Gly Leu Ser Lys Leu Gly 
        275                 280                 285


Leu Glu Leu Tyr Pro Ser Arg Leu Glu Ser Leu Asp Asn Arg Gly His 
    290                 295                 300


Ala Asn Trp Glu Ile Leu Ala Pro Ile Arg Ala Glu Leu Met Cys Thr 
305                 310                 315                 320


Leu Arg Glu Glu Arg Pro Lys Val Phe Lys Pro Arg Val Pro Ala Trp 
                325                 330                 335


Phe Phe Leu Arg Thr Glu His Leu Leu Asp Tyr Ile Gln Ile Cys Phe 
            340                 345                 350


Pro Cys Arg Phe Val Lys Met Ser Ile Arg Thr Pro Pro Arg Leu Leu 
        355                 360                 365


Glu Leu Ala Gly Arg Ser Leu Leu Arg Asp Gln Ala Leu Ala Met Ser 
    370                 375                 380


Thr Leu Glu Glu Leu Pro Thr Glu Leu Phe Pro Pro Leu Phe Met Glu 
385                 390                 395                 400


Ala Phe Ser Arg Arg Arg Cys Glu Ala Leu Lys Leu Met Val Gln Ala 
                405                 410                 415


Trp Pro Phe Arg Arg Leu Pro Leu Arg Pro Leu Ile Lys Met Pro Cys 
            420                 425                 430


Leu Glu Ala Phe Gln Ala Val Leu Asp Gly Leu Asp Ala Leu Leu Thr 
        435                 440                 445


Gln Gly Val His Pro Arg Arg Trp Lys Leu Gln Val Leu Asp Leu Gln 
    450                 455                 460


Asp Val Cys Glu Asn Phe Trp Met Val Trp Ser Glu Ala Met Ala His 
465                 470                 475                 480


Gly Cys Phe Leu Asn Ala Lys Arg Asn Lys Lys Pro Val Gln Asp Cys 
                485                 490                 495


Pro Arg Met Arg Gly Gln Gln Pro Leu Thr Val Phe Val Glu Leu Trp 
            500                 505                 510


Leu Lys Asn Arg Thr Leu Asp Glu Tyr Leu Thr Cys Leu Leu Leu Trp 
        515                 520                 525


Val Lys Gln Arg Lys Asp Leu Leu His Leu Cys Cys Lys Lys Leu Lys 
    530                 535                 540


Ile Leu Gly Met Pro Phe Arg Asn Ile Arg Ser Ile Leu Lys Met Val 
545                 550                 555                 560


Asn Leu Asp Cys Ile Gln Glu Val Glu Val Asn Cys Lys Trp Val Leu 
                565                 570                 575


Pro Ile Leu Thr Gln Phe Thr Pro Tyr Leu Gly His Met Arg Asn Leu 
            580                 585                 590


Gln Lys Leu Val Leu Ser His Met Asp Val Ser Arg Tyr Val Ser Pro 
        595                 600                 605


Glu Gln Lys Lys Glu Ile Val Thr Gln Phe Thr Thr Gln Phe Leu Lys 
    610                 615                 620


Leu Cys Cys Leu Gln Lys Leu Ser Met Asn Ser Val Ser Phe Leu Glu 
625                 630                 635                 640


Gly His Leu Asp Gln Leu Leu Ser Cys Leu Lys Thr Ser Leu Lys Val 
                645                 650                 655


Leu Thr Ile Thr Asn Cys Val Leu Leu Glu Ser Asp Leu Lys His Leu 
            660                 665                 670


Ser Gln Cys Pro Ser Ile Ser Gln Leu Lys Thr Leu Asp Leu Ser Gly 
        675                 680                 685


Ile Arg Leu Thr Asn Tyr Ser Leu Val Pro Leu Gln Ile Leu Leu Glu 
    690                 695                 700


Lys Val Ala Ala Thr Leu Glu Tyr Leu Asp Leu Asp Asp Cys Gly Ile 
705                 710                 715                 720


Ile Asp Ser Gln Val Asn Ala Ile Leu Pro Ala Leu Ser Cys Cys Phe 
                725                 730                 735


Glu Leu Asn Thr Phe Ser Phe Cys Gly Asn Pro Ile Ser Met Ala Thr 
            740                 745                 750


Leu Glu Asn Leu Leu Ser His Thr Ile Ile Leu Lys Asn Leu Cys Val 
        755                 760                 765


Glu Leu Tyr Pro Ala Pro Arg Glu Ser Tyr Asp Ala Asp Gly Thr Leu 
    770                 775                 780


Cys Trp Ser Arg Phe Pro Gln Ile Arg Ala Glu Leu Met Lys Arg Val 
785                 790                 795                 800


Arg Asp Leu Arg His Pro Lys Arg Ile Leu Phe Cys Thr Asp Cys Cys 
                805                 810                 815


Pro Asp Cys Gly Asn Arg Ser Phe Tyr Asp Leu Glu Ala Asp Gln Cys 
            820                 825                 830


Cys Cys 



<210>  1493
<211>  1785
<212>  DNA
<213>  Homo sapiens

<400>  1493
atgagcctac aggccccacg cagactcctg gagctggcag ggcagagcct gctgggggac     60

caggccttgg ccatctccat cttggatgag ctgcccaggg agctcttccc cccactgttc    120

gtggaggcct tcactagcag acgctgcgag gttctgaagg tgatggtgca ggcctggccc    180

ttcccctgcc tccctctggg gtccctgatg aagacgcctg atctggagat cttacattat    240

gtagtggatg ggattgattg cctgcttgcc caaaaggttc gccccaggcg gaaacttcaa    300

gtgctggaat tgcgggatgt tgatgagaat ttttggacca tatggtctgg agccaggccc    360

ctgtcctgct ccccagaggc catgagtaag aggcagacag tggaggactg tccaaggaca    420

ggagagaagc agcccttgaa ggtgttcatg gatgtttgcc tcaaggaaaa attcatggat    480

gaagatctga gcttcttctc tggaaacata ttggaaacag tatacccaga cagtatccaa    540

gtgttggaaa tttggaacat gtgctggccg tgtatgatag tagagtttag cccttacctg    600

agccagatga ggaatcttcg caaactcttc atctccgatg gctgtcgtta cctgctaagc    660

tctgacagcc aagaacagtt agttgctgaa ttcagctctg tgctcctcag gctggagaac    720

ctccagatgc tttatgtaag aagggtctgc ttcttcagag gccacctgga ccagctgatc    780

aggtgagagc agaagaagga gattgttacc cagttcacca ctcagttcct caagctgcac    840

tgcctccaaa agctttatat gaactctgtt tctttcctcg aaggccacct ggaccagctg    900

ctcagctgtc tgaagacctc gttaaaggtc ctcacaataa ctaactgtgt gcttttggaa    960

tcagacttga agcatctatc ccagtgcccg agtatcagtc aactaaagac cctggacctg   1020

agtggcatca gactgaccaa ttacagtctt gtgcctctcc aaattctcct agaaaaagtt   1080

gcagccaccc ttgagtacct ggatttagat gactgtggca tcatagactc ccaagtcaac   1140

gccatcctgc ctgccctgag ccgctgcttt gagctcaaca ccttcagctt ctgtggaaat   1200

cccatctcca tggccaccct ggagaacctg ctgagccaca caatcatact caaaaactta   1260

tgcctggagc tgtatcctgc cccacgggag agttatggtg ctgatggtac tctctgctgg   1320

agcagattta ctcagattag ggctgagctg atgaagagag ttagggactt aaggcacccc   1380

aagaggatct tgttcggtac tgactactgc cctgactgtg gcaacaggtc attttatgac   1440

ctggaggcag atcaatactg ctgttgaatg cctgcctatt tggatgggta tgtcaaacgc   1500

tttcttctgg acacttggaa actaaaacct aggtcttagg tacatcctaa agggagcaca   1560

gaacccatcg tttcacacat gggctctgaa agtgggaaag gaatgctgat caagcagggg   1620

caggacttgg gggaaatgtt gccatggatt cgatgggact ttgggaacgt gtatcctgta   1680

gagtcgaaaa tgggaatctg aatgtctaga gtggaattca ggcttgagaa tacatgaggg   1740

agttactctt gcatggatgg ttgtaaataa acaatcagaa ataaa                   1785


<210>  1494
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  1494

Met Ser Leu Gln Ala Pro Arg Arg Leu Leu Glu Leu Ala Gly Gln Ser 
1               5                   10                  15


Leu Leu Gly Asp Gln Ala Leu Ala Ile Ser Ile Leu Asp Glu Leu Pro 
            20                  25                  30


Arg Glu Leu Phe Pro Pro Leu Phe Val Glu Ala Phe Thr Ser Arg Arg 
        35                  40                  45


Cys Glu Val Leu Lys Val Met Val Gln Ala Trp Pro Phe Pro Cys Leu 
    50                  55                  60


Pro Leu Gly Ser Leu Met Lys Thr Pro Asp Leu Glu Ile Leu His Tyr 
65                  70                  75                  80


Val Val Asp Gly Ile Asp Cys Leu Leu Ala Gln Lys Val Arg Pro Arg 
                85                  90                  95


Arg Lys Leu Gln Val Leu Glu Leu Arg Asp Val Asp Glu Asn Phe Trp 
            100                 105                 110


Thr Ile Trp Ser Gly Ala Arg Pro Leu Ser Cys Ser Pro Glu Ala Met 
        115                 120                 125


Ser Lys Arg Gln Thr Val Glu Asp Cys Pro Arg Thr Gly Glu Lys Gln 
    130                 135                 140


Pro Leu Lys Val Phe Met Asp Val Cys Leu Lys Glu Lys Phe Met Asp 
145                 150                 155                 160


Glu Asp Leu Ser Phe Phe Ser Gly Asn Ile Leu Glu Thr Val Tyr Pro 
                165                 170                 175


Asp Ser Ile Gln Val Leu Glu Ile Trp Asn Met Cys Trp Pro Cys Met 
            180                 185                 190


Ile Val Glu Phe Ser Pro Tyr Leu Ser Gln Met Arg Asn Leu Arg Lys 
        195                 200                 205


Leu Phe Ile Ser Asp Gly Cys Arg Tyr Leu Leu Ser Ser Asp Ser Gln 
    210                 215                 220


Glu Gln Leu Val Ala Glu Phe Ser Ser Val Leu Leu Arg Leu Glu Asn 
225                 230                 235                 240


Leu Gln Met Leu Tyr Val Arg Arg Val Cys Phe Phe Arg Gly His Leu 
                245                 250                 255


Asp Gln Leu Ile Arg 
            260


<210>  1495
<211>  1758
<212>  DNA
<213>  Homo sapiens

<400>  1495
atggaggcct tcagcatgag atgttgtgag gccctgaagc tgatggtgca ggcctggtcc     60

tcccttcacc tccctctggg atccctgatg aagacaactc atctggagac cttgcaagct    120

gtgctgaagg gacttgatac actagtgtcc cagaagatcc tctggaaaag gactgctcac    180

catacagagt ccactgagga aacaggaacc tgcttcctcc cagtggaaga ggccatgagt    240

aagaggcaga cagtggagga ctgtccaagg atgggagagt gccagccctt gaaggtgttc    300

atagacctct gcctgaagga aaccttcggt tatgagcctg aattatacgt gagcggccaa    360

tggcagttca ttcctgactt ggattggcca ttcctgtgcc tgtactaccc ccagatgcat    420

tatataagaa aggtcagtaa tatcaaagag cacctggagc acctgctcag acattcttcc    480

tggtaccagc agaagcagaa atatagattt gtggccacca agtgcagagt ggaattggga    540

gtttttcctt acagattcat caggatgagc atccaggccc cacccagact cctggagctg    600

gcggggcaga gtctgctgag agacaagccc ttggccatct ctgccctgga ggagctgccc    660

agggagctct acctcccact cttcctggag gccttcagca ggagacactt ccagactctg    720

acagtgatgg tgcaggcctg gcccttcacc cgcctccctc tgggatcgct gatgaagacg    780

cttcatctgg agaccttaaa agcattgctg gaagggcttc acatgctgct tacacagaag    840

gatcgcccca ggaggtggaa acttcaagtg ctggatttgc gggatgttga tgagaatttc    900

tgggccatat ggtctgaatc cagggccctg tcctcctccc cagaggccat gagtaagagg    960

cagacagcag aggactgtcc aaggatggga gagcaccagc ccttgaaggt gttcatagac   1020

atctgcctca aggaaatacc ccaggatgaa tgcctgagat acctcttccg aaagcttcat   1080

tgttacctga aggagatgaa gaatcttcgc aaactcattt ttctccaggt gccatcctta   1140

cacgtcaatt accgcgagga atgctcagtc gccaaaatca gctctatgtt cctcaggctg   1200

aaacacctcc agctgcttaa aatgaatatg gtcaccttcc acagagggca cctgggacag   1260

ctgatcagca acttgcatga ggaccatcat cagatgaacc ccttggagaa cttggaatta   1320

acttgcggct acctattgga agaggacttg aagtgtctct accagtaccc aagcctcgct   1380

tacccaaagc atctgaatct cagctacatg ctgcagttct gtatcagtct tgaacccctc   1440

ggagctctgc tggagaaagt ttctgccaac acgagggtct cgagagaggc agcaattact   1500

cttaagaccc tcatctcgga gggctgtcag atccactact cccaactcag tgccatcctg   1560

cctggcctga gccgctgctc ccagctcacc accttctact ttggcagaaa ttgcatgtct   1620

atggaagccc tgaaggacct gctgtgccac accagtgggc tgagcaagtt aagcctggag   1680

atgtatcctg cccccgagga gagtttgaat tccttggttc atgtcgattg ggagatcttc   1740

accccacttc gggcttag                                                 1758


<210>  1496
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  1496

Met Glu Ala Phe Ser Met Arg Cys Cys Glu Ala Leu Lys Leu Met Val 
1               5                   10                  15


Gln Ala Trp Ser Ser Leu His Leu Pro Leu Gly Ser Leu Met Lys Thr 
            20                  25                  30


Thr His Leu Glu Thr Leu Gln Ala Val Leu Lys Gly Leu Asp Thr Leu 
        35                  40                  45


Val Ser Gln Lys Ile Leu Trp Lys Arg Thr Ala His His Thr Glu Ser 
    50                  55                  60


Thr Glu Glu Thr Gly Thr Cys Phe Leu Pro Val Glu Glu Ala Met Ser 
65                  70                  75                  80


Lys Arg Gln Thr Val Glu Asp Cys Pro Arg Met Gly Glu Cys Gln Pro 
                85                  90                  95


Leu Lys Val Phe Ile Asp Leu Cys Leu Lys Glu Thr Phe Gly Tyr Glu 
            100                 105                 110


Pro Glu Leu Tyr Val Ser Gly Gln Trp Gln Phe Ile Pro Asp Leu Asp 
        115                 120                 125


Trp Pro Phe Leu Cys Leu Tyr Tyr Pro Gln Met His Tyr Ile Arg Lys 
    130                 135                 140


Val Ser Asn Ile Lys Glu His Leu Glu His Leu Leu Arg His Ser Ser 
145                 150                 155                 160


Trp Tyr Gln Gln Lys Gln Lys Tyr Arg Phe Val Ala Thr Lys Cys Arg 
                165                 170                 175


Val Glu Leu Gly Val Phe Pro Tyr Arg Phe Ile Arg Met Ser Ile Gln 
            180                 185                 190


Ala Pro Pro Arg Leu Leu Glu Leu Ala Gly Gln Ser Leu Leu Arg Asp 
        195                 200                 205


Lys Pro Leu Ala Ile Ser Ala Leu Glu Glu Leu Pro Arg Glu Leu Tyr 
    210                 215                 220


Leu Pro Leu Phe Leu Glu Ala Phe Ser Arg Arg His Phe Gln Thr Leu 
225                 230                 235                 240


Thr Val Met Val Gln Ala Trp Pro Phe Thr Arg Leu Pro Leu Gly Ser 
                245                 250                 255


Leu Met Lys Thr Leu His Leu Glu Thr Leu Lys Ala Leu Leu Glu Gly 
            260                 265                 270


Leu His Met Leu Leu Thr Gln Lys Asp Arg Pro Arg Arg Trp Lys Leu 
        275                 280                 285


Gln Val Leu Asp Leu Arg Asp Val Asp Glu Asn Phe Trp Ala Ile Trp 
    290                 295                 300


Ser Glu Ser Arg Ala Leu Ser Ser Ser Pro Glu Ala Met Ser Lys Arg 
305                 310                 315                 320


Gln Thr Ala Glu Asp Cys Pro Arg Met Gly Glu His Gln Pro Leu Lys 
                325                 330                 335


Val Phe Ile Asp Ile Cys Leu Lys Glu Ile Pro Gln Asp Glu Cys Leu 
            340                 345                 350


Arg Tyr Leu Phe Arg Lys Leu His Cys Tyr Leu Lys Glu Met Lys Asn 
        355                 360                 365


Leu Arg Lys Leu Ile Phe Leu Gln Val Pro Ser Leu His Val Asn Tyr 
    370                 375                 380


Arg Glu Glu Cys Ser Val Ala Lys Ile Ser Ser Met Phe Leu Arg Leu 
385                 390                 395                 400


Lys His Leu Gln Leu Leu Lys Met Asn Met Val Thr Phe His Arg Gly 
                405                 410                 415


His Leu Gly Gln Leu Ile Ser Asn Leu His Glu Asp His His Gln Met 
            420                 425                 430


Asn Pro Leu Glu Asn Leu Glu Leu Thr Cys Gly Tyr Leu Leu Glu Glu 
        435                 440                 445


Asp Leu Lys Cys Leu Tyr Gln Tyr Pro Ser Leu Ala Tyr Pro Lys His 
    450                 455                 460


Leu Asn Leu Ser Tyr Met Leu Gln Phe Cys Ile Ser Leu Glu Pro Leu 
465                 470                 475                 480


Gly Ala Leu Leu Glu Lys Val Ser Ala Asn Thr Arg Val Ser Arg Glu 
                485                 490                 495


Ala Ala Ile Thr Leu Lys Thr Leu Ile Ser Glu Gly Cys Gln Ile His 
            500                 505                 510


Tyr Ser Gln Leu Ser Ala Ile Leu Pro Gly Leu Ser Arg Cys Ser Gln 
        515                 520                 525


Leu Thr Thr Phe Tyr Phe Gly Arg Asn Cys Met Ser Met Glu Ala Leu 
    530                 535                 540


Lys Asp Leu Leu Cys His Thr Ser Gly Leu Ser Lys Leu Ser Leu Glu 
545                 550                 555                 560


Met Tyr Pro Ala Pro Glu Glu Ser Leu Asn Ser Leu Val His Val Asp 
                565                 570                 575


Trp Glu Ile Phe Thr Pro Leu Arg Ala 
            580                 585


<210>  1497
<211>  1687
<212>  DNA
<213>  Homo sapiens

<400>  1497
ctaaactaca accagatctg aattcttgtt ggcagccatt ttgtgaagag acgaagactg     60

agctgttttg gctgcatttc tggcctcgag ccgcagtcag cttctccccg tagaacccgg    120

cagtaggaga cttagaatcg aatctcttct ccctcccgcc tcctgttttt ggctttttga    180

gaaaccttat catccaacac aatggccagc aacgttacca acaagatgga tcctcactcc    240

gtgaactccc gtgtgttcat tgggaatctc aacactcttg ttgtcaagaa atctgatgtg    300

gaggcgatct tttccaagta tggcaaaatt gcgggctgct ctgttcataa gggctttgcc    360

ttcgttcaat atgataagga gaaaaatgcc cgggctgctg tagcaggaga ggatggcaga    420

atgattgcta gccaggttgc agttattaac ctggctgcag agccaaaagt gaaccgagga    480

aacgcaggtg tgaaacgatc cgcagcggag atgtacggct cctcttttga cttggactat    540

ggctttcaac gggattatta tgatgggatg tacagtttcc cagcacgtgt acctcctcct    600

cctcccattg ctctggctgt agtgccctcg aaacaccagc gcatatcagg aaacacctca    660

cgaaggggca aaagtggctt caattctaag agtggaaagc ggggatcttc caagtctgga    720

aagctgaaag gagatgacct tcaggccatt aagcaggagt tgacccagat aaaacagaaa    780

gtggattctc tcctggaaaa cctggaaaaa attgaaaagg aacagagcaa acaagaggta    840

gaggtgaaaa atgctaagtc agaagaggag cagagcagta gctccatgaa gaaagatgag    900

actcatgtaa agatggagtc tgaggggggt gcagaagact ctgctgagga gggggaccca    960

ctggatgatg atgataatga agatcagggg gacaaccagc ttcatttgat caagaataat   1020

gaaaaagatg ctgaggaagg agaggataac agagacagca ccaatggcca ggatgactct   1080

taagcacata gtggggttga gaaatcttat cccattgttt ctttacctag gagcttgtct   1140

aacaacaaat ttttcaccag atcctctccc ttagtatctt cagcacatgc ttactgttct   1200

ccccatcctt gtccttccca cattcattaa ttcatattgc cctgtgccta gtcccatttt   1260

cacttcccat gacaccccta gtagttttcc taagtcttac cctgtaattt ttgcttttaa   1320

ttttgacacc tctttatgac ttaacagtaa aaaggatgta tggtttttat caactgtctc   1380

caaaataatc tcttgttatg cagggaatac agttcttttc tttcatacat aagttcagta   1440

gttgcttccc taactgcaaa ggcaatctca ttgagttgag tagctcctga aagcagcttg   1500

gagttacaag tatgtgtgtt acaccccata ttagtgtgct gtgtggggca gttcaacaaa   1560

aatctaacaa tgtatttttg tgaatgagag ttggcatgtc aaatgcatcc tcagaaacat   1620

aattggtgtt atagtcttca aatgtgtttt ctaaagttga taccgtgggt tatttttgtg   1680

aacagct                                                             1687


<210>  1498
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  1498

Met Ala Ser Asn Val Thr Asn Lys Met Asp Pro His Ser Val Asn Ser 
1               5                   10                  15


Arg Val Phe Ile Gly Asn Leu Asn Thr Leu Val Val Lys Lys Ser Asp 
            20                  25                  30


Val Glu Ala Ile Phe Ser Lys Tyr Gly Lys Ile Ala Gly Cys Ser Val 
        35                  40                  45


His Lys Gly Phe Ala Phe Val Gln Tyr Asp Lys Glu Lys Asn Ala Arg 
    50                  55                  60


Ala Ala Val Ala Gly Glu Asp Gly Arg Met Ile Ala Ser Gln Val Ala 
65                  70                  75                  80


Val Ile Asn Leu Ala Ala Glu Pro Lys Val Asn Arg Gly Asn Ala Gly 
                85                  90                  95


Val Lys Arg Ser Ala Ala Glu Met Tyr Gly Ser Ser Phe Asp Leu Asp 
            100                 105                 110


Tyr Gly Phe Gln Arg Asp Tyr Tyr Asp Gly Met Tyr Ser Phe Pro Ala 
        115                 120                 125


Arg Val Pro Pro Pro Pro Pro Ile Ala Leu Ala Val Val Pro Ser Lys 
    130                 135                 140


His Gln Arg Ile Ser Gly Asn Thr Ser Arg Arg Gly Lys Ser Gly Phe 
145                 150                 155                 160


Asn Ser Lys Ser Gly Lys Arg Gly Ser Ser Lys Ser Gly Lys Leu Lys 
                165                 170                 175


Gly Asp Asp Leu Gln Ala Ile Lys Gln Glu Leu Thr Gln Ile Lys Gln 
            180                 185                 190


Lys Val Asp Ser Leu Leu Glu Asn Leu Glu Lys Ile Glu Lys Glu Gln 
        195                 200                 205


Ser Lys Gln Glu Val Glu Val Lys Asn Ala Lys Ser Glu Glu Glu Gln 
    210                 215                 220


Ser Ser Ser Ser Met Lys Lys Asp Glu Thr His Val Lys Met Glu Ser 
225                 230                 235                 240


Glu Gly Gly Ala Glu Asp Ser Ala Glu Glu Gly Asp Pro Leu Asp Asp 
                245                 250                 255


Asp Asp Asn Glu Asp Gln Gly Asp Asn Gln Leu His Leu Ile Lys Asn 
            260                 265                 270


Asn Glu Lys Asp Ala Glu Glu Gly Glu Asp Asn Arg Asp Ser Thr Asn 
        275                 280                 285


Gly Gln Asp Asp Ser 
    290


<210>  1499
<211>  1362
<212>  DNA
<213>  Homo sapiens

<400>  1499
atgttcatgg tgaaaactga gaatggaggc tgtctggggc cacaggacac tctcattctc     60

attgctttag ggcgacattc ttcctggtac cagcagaagc agaaatatag atttgtggcc    120

accaagtgca gagtggaatt gggagttttt ccttacagat tcatcaggat gagcatccag    180

gccccaccca gactcctgga gctggcgggg cagagtctgc tgagagacaa gcccttggcc    240

atctctgccc tggaggagct gcccagggag ctctacctcc cactcttcct ggaggccttc    300

agcaggagac acttccagac tctgacagtg atggtgcagg cctggccctt cacccgcctc    360

cctctgggat cgctgatgaa gacgcttcat ctggagacct taaaagcatt gctggaaggg    420

cttcacatgc tgcttacaca gaaggatcgc cccaggaggt ggaaacttca agtgctggat    480

ttgcgggatg ttgatgagaa tttctgggcc atatggtctg aatccagggc cctgtcctcc    540

tccccagagg ccatgagtaa gaggcagaca gcagaggact gtccaaggat gggagagcac    600

cagcccttga aggtgttcat agacatctgc ctcaaggaaa taccccagga tgaatgcctg    660

agatacctct tccgaaagct tcattgttac ctgaaggaga tgaagaatct tcgcaaactc    720

atttttctcc aggtgccatc cttacacgtc aattaccgcg aggaatgctc agtcgccaaa    780

atcagctcta tgttcctcag gctgaaacac ctccagctgc ttaaaatgaa tatggtcacc    840

ttccacagag ggcacctggg acagctgatc agcaacttgc atgaggacca tcatcagatg    900

aaccccttgg agaacttgga attaacttgc ggctacctat tggaagagga cttgaagtgt    960

ctctaccagt acccaagcct cgcttaccca aagcatctga atctcagcta catgctgcag   1020

ttctgtatca gtcttgaacc cctcggagct ctgctggaga aagtttctgc caacacgagg   1080

gtctcgagag aggcagcaat tactcttaag accctcatct tggagggctg tcagatccac   1140

tactcccaac tcagtgccat cctgcctggc ctgagccgct gctcccagct caccaccttc   1200

tactttggca gaaattgcat gtctatggaa gccctgaagg acctgctgtg ccacaccagt   1260

gggctgagca agttaagcct ggagatgtat cctgcccccg aggagagttt gaattccttg   1320

gttcatgtcg attgggagat cttcacccca cttcgggctt ag                      1362


<210>  1500
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  1500

Met Phe Met Val Lys Thr Glu Asn Gly Gly Cys Leu Gly Pro Gln Asp 
1               5                   10                  15


Thr Leu Ile Leu Ile Ala Leu Gly Arg His Ser Ser Trp Tyr Gln Gln 
            20                  25                  30


Lys Gln Lys Tyr Arg Phe Val Ala Thr Lys Cys Arg Val Glu Leu Gly 
        35                  40                  45


Val Phe Pro Tyr Arg Phe Ile Arg Met Ser Ile Gln Ala Pro Pro Arg 
    50                  55                  60


Leu Leu Glu Leu Ala Gly Gln Ser Leu Leu Arg Asp Lys Pro Leu Ala 
65                  70                  75                  80


Ile Ser Ala Leu Glu Glu Leu Pro Arg Glu Leu Tyr Leu Pro Leu Phe 
                85                  90                  95


Leu Glu Ala Phe Ser Arg Arg His Phe Gln Thr Leu Thr Val Met Val 
            100                 105                 110


Gln Ala Trp Pro Phe Thr Arg Leu Pro Leu Gly Ser Leu Met Lys Thr 
        115                 120                 125


Leu His Leu Glu Thr Leu Lys Ala Leu Leu Glu Gly Leu His Met Leu 
    130                 135                 140


Leu Thr Gln Lys Asp Arg Pro Arg Arg Trp Lys Leu Gln Val Leu Asp 
145                 150                 155                 160


Leu Arg Asp Val Asp Glu Asn Phe Trp Ala Ile Trp Ser Glu Ser Arg 
                165                 170                 175


Ala Leu Ser Ser Ser Pro Glu Ala Met Ser Lys Arg Gln Thr Ala Glu 
            180                 185                 190


Asp Cys Pro Arg Met Gly Glu His Gln Pro Leu Lys Val Phe Ile Asp 
        195                 200                 205


Ile Cys Leu Lys Glu Ile Pro Gln Asp Glu Cys Leu Arg Tyr Leu Phe 
    210                 215                 220


Arg Lys Leu His Cys Tyr Leu Lys Glu Met Lys Asn Leu Arg Lys Leu 
225                 230                 235                 240


Ile Phe Leu Gln Val Pro Ser Leu His Val Asn Tyr Arg Glu Glu Cys 
                245                 250                 255


Ser Val Ala Lys Ile Ser Ser Met Phe Leu Arg Leu Lys His Leu Gln 
            260                 265                 270


Leu Leu Lys Met Asn Met Val Thr Phe His Arg Gly His Leu Gly Gln 
        275                 280                 285


Leu Ile Ser Asn Leu His Glu Asp His His Gln Met Asn Pro Leu Glu 
    290                 295                 300


Asn Leu Glu Leu Thr Cys Gly Tyr Leu Leu Glu Glu Asp Leu Lys Cys 
305                 310                 315                 320


Leu Tyr Gln Tyr Pro Ser Leu Ala Tyr Pro Lys His Leu Asn Leu Ser 
                325                 330                 335


Tyr Met Leu Gln Phe Cys Ile Ser Leu Glu Pro Leu Gly Ala Leu Leu 
            340                 345                 350


Glu Lys Val Ser Ala Asn Thr Arg Val Ser Arg Glu Ala Ala Ile Thr 
        355                 360                 365


Leu Lys Thr Leu Ile Leu Glu Gly Cys Gln Ile His Tyr Ser Gln Leu 
    370                 375                 380


Ser Ala Ile Leu Pro Gly Leu Ser Arg Cys Ser Gln Leu Thr Thr Phe 
385                 390                 395                 400


Tyr Phe Gly Arg Asn Cys Met Ser Met Glu Ala Leu Lys Asp Leu Leu 
                405                 410                 415


Cys His Thr Ser Gly Leu Ser Lys Leu Ser Leu Glu Met Tyr Pro Ala 
            420                 425                 430


Pro Glu Glu Ser Leu Asn Ser Leu Val His Val Asp Trp Glu Ile Phe 
        435                 440                 445


Thr Pro Leu Arg Ala 
    450


<210>  1501
<211>  667
<212>  DNA
<213>  Homo sapiens

<400>  1501
tatctcagaa gatcattgaa aataatccac ctgaatagta ttcaggagct ggaaatttgc     60

tatgtgtcct ggccacatct gataagaaag cttcattgtt acctgaagga gatgaagaat    120

cttcgcaaac tcatttttct ccaggtgcca tccttacacg tcaattaccg cgaggaatgc    180

tcagtcgcca aaatcagctc tatgttcctc aggctgaaac acctccagct gcttaaaatg    240

aatatggtca ccttccacag agggcacctg ggacagctga tcaggtgcct ctagaacccc    300

ttggagaact tggaattaac ttgcggctac ctattggaag aggacttgaa gtgtctctac    360

cagtacccaa gcctcgctta cccaaagcat ctgaatctca gctacatgct gcagttctgt    420

atcagtcttg aacccctcgg agctctgctg gagaaagttt ctgccaacac gagggtctcg    480

agagaggcag caattactct taagaccctc atcttggagg gctgtcagat ccactactcc    540

caactcagtg ccatcctgcc tggcctgagc cgctgctccc agctcaccac cttctacttt    600

ggcagaaatt gcatgtctat ggaagccctg aaggacctgc tgtgccacac cagtgggctg    660

agcaagt                                                              667


<210>  1502
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  1502

Met Lys Asn Leu Arg Lys Leu Ile Phe Leu Gln Val Pro Ser Leu His 
1               5                   10                  15


Val Asn Tyr Arg Glu Glu Cys Ser Val Ala Lys Ile Ser Ser Met Phe 
            20                  25                  30


Leu Arg Leu Lys His Leu Gln Leu Leu Lys Met Asn Met Val Thr Phe 
        35                  40                  45


His Arg Gly His Leu Gly Gln Leu Ile Arg Cys Leu 
    50                  55                  60


<210>  1503
<211>  1484
<212>  DNA
<213>  Homo sapiens

<400>  1503
tctcacctct attttcccac aggaggtgga aacttcaagt gctggattta caggatgtct     60

gtgagaactt ctggatggtt tggtctgaag ctatggcccg tgggtgcttc ctcaatgcca    120

agaggaacaa aaaaccagtg caggactgtc caaggatgag aggacggcag cccttgactg    180

tgttcgtaga actttggctc aagaacagga ctctggatga acacctcacc tgcctccttc    240

tatgggtcaa gcagaggaaa gatttactac acctgtgctg taagaagctg aaaattttgg    300

gaatgccctt ccgcaatatc agaagcatcc tgaaaatggt gaacctagac tgtatccagg    360

aggtggaagt gaattgcaag tgggtactgc ccatcctgac acagtttacc ccatacctgg    420

gccacatgag gaatcttcag aagctcgttc tctcccacat ggatgtctct cgctacgttt    480

ccccagagca gaagaaggag attgttaccc agttcaccac tcagttcctc aagctgcact    540

gcctccaaaa gctttatatg aactctgttt ctttcctcga aggccacctg gaccagctgc    600

tcagctgtct gaagacctcg ttaaaggtcc tcacaataac taactgtgtg cttttggaat    660

cagacttgaa gcatctatcc cagtgcccga gtatcagtca actaaagacc ctggacctga    720

gtggcatcag actgaccaat tacagtcttg tgcctctcca aattctccta gaaaaagttg    780

cagccaccct tgagtacctg gatttagatg actgtggcat catagactcc caagtcaacg    840

ccatcctgcc tgccctgagc cgctgctttg agctcaacac cttcagcttc tgtggaaatc    900

ccatctccat ggccaccctg gagaacctgc tgagccacac aatcatactc aaaaacttat    960

gcctggagct gtatcctgcc ccacgggaga gttatggtgc tgatggtact ctctgctgga   1020

gcagatttac tcagattagg gctgagctga tgaagagagt tagggactta aggcacccca   1080

agaggatctt gttcggtact gactactgcc ctgactgtgg caacaggtca ttttatgacc   1140

tggaggcaga tcaatactgc tgttgaatgc ctgcctattt ggatgggtat gtcaaacgct   1200

ttcttctgga cacttggaaa ctaaaaccta ggtcttaggt acatcctaaa gggagcacag   1260

aacccatcgt ttcacacatg ggctctgaaa gtgggaaagg aatgctgatc aagcaggggc   1320

aggacttggg ggaaatgttg ccatggattc gatgggactt tggggacctg tatcctgtag   1380

agtcgaaaat gggaatctga atgtctagag tggaattcag gcttgagaat acatgaggga   1440

gttactcttg catggatggt tgtaaagaaa caatcagaaa taaa                    1484


<210>  1504
<211>  363
<212>  PRT
<213>  Homo sapiens

<400>  1504

Met Val Trp Ser Glu Ala Met Ala Arg Gly Cys Phe Leu Asn Ala Lys 
1               5                   10                  15


Arg Asn Lys Lys Pro Val Gln Asp Cys Pro Arg Met Arg Gly Arg Gln 
            20                  25                  30


Pro Leu Thr Val Phe Val Glu Leu Trp Leu Lys Asn Arg Thr Leu Asp 
        35                  40                  45


Glu His Leu Thr Cys Leu Leu Leu Trp Val Lys Gln Arg Lys Asp Leu 
    50                  55                  60


Leu His Leu Cys Cys Lys Lys Leu Lys Ile Leu Gly Met Pro Phe Arg 
65                  70                  75                  80


Asn Ile Arg Ser Ile Leu Lys Met Val Asn Leu Asp Cys Ile Gln Glu 
                85                  90                  95


Val Glu Val Asn Cys Lys Trp Val Leu Pro Ile Leu Thr Gln Phe Thr 
            100                 105                 110


Pro Tyr Leu Gly His Met Arg Asn Leu Gln Lys Leu Val Leu Ser His 
        115                 120                 125


Met Asp Val Ser Arg Tyr Val Ser Pro Glu Gln Lys Lys Glu Ile Val 
    130                 135                 140


Thr Gln Phe Thr Thr Gln Phe Leu Lys Leu His Cys Leu Gln Lys Leu 
145                 150                 155                 160


Tyr Met Asn Ser Val Ser Phe Leu Glu Gly His Leu Asp Gln Leu Leu 
                165                 170                 175


Ser Cys Leu Lys Thr Ser Leu Lys Val Leu Thr Ile Thr Asn Cys Val 
            180                 185                 190


Leu Leu Glu Ser Asp Leu Lys His Leu Ser Gln Cys Pro Ser Ile Ser 
        195                 200                 205


Gln Leu Lys Thr Leu Asp Leu Ser Gly Ile Arg Leu Thr Asn Tyr Ser 
    210                 215                 220


Leu Val Pro Leu Gln Ile Leu Leu Glu Lys Val Ala Ala Thr Leu Glu 
225                 230                 235                 240


Tyr Leu Asp Leu Asp Asp Cys Gly Ile Ile Asp Ser Gln Val Asn Ala 
                245                 250                 255


Ile Leu Pro Ala Leu Ser Arg Cys Phe Glu Leu Asn Thr Phe Ser Phe 
            260                 265                 270


Cys Gly Asn Pro Ile Ser Met Ala Thr Leu Glu Asn Leu Leu Ser His 
        275                 280                 285


Thr Ile Ile Leu Lys Asn Leu Cys Leu Glu Leu Tyr Pro Ala Pro Arg 
    290                 295                 300


Glu Ser Tyr Gly Ala Asp Gly Thr Leu Cys Trp Ser Arg Phe Thr Gln 
305                 310                 315                 320


Ile Arg Ala Glu Leu Met Lys Arg Val Arg Asp Leu Arg His Pro Lys 
                325                 330                 335


Arg Ile Leu Phe Gly Thr Asp Tyr Cys Pro Asp Cys Gly Asn Arg Ser 
            340                 345                 350


Phe Tyr Asp Leu Glu Ala Asp Gln Tyr Cys Cys 
        355                 360


<210>  1505
<211>  2104
<212>  DNA
<213>  Homo sapiens

<400>  1505
gatttgtttt cttgcagatt tatgaggatg agcctacagg ccccacgcag actcctggag     60

ctggcagggc agagcctgct gggggaccag gccttggcca tctccatctt ggatgagctg    120

cccagggagc tcttcccccc actgttcgtg gaggccttca ctagcagacg ctgcgaggtt    180

ctgaaggtga tggtgcaggc ctggcccttc ccctgcctcc ctctggggtc cctgatgaag    240

acgcctgatc tggagatctt acattatgta gtggatggga ttgattgcct gcttgcccaa    300

aaggttcgcc ccaggaggcg gaaacttcaa gtgctggaat tgcgggatgt tgatgagaat    360

ttttggacca tatggtctgg agccaggccc ctgtcctgct ccccagaggc catgagtaag    420

aggcagacag tggaggactg tccaaggaca ggagagaagc agcccttgaa ggtgttcatg    480

gatgtttgcc tcaaggaaaa attcatggat gaagatctga gcttcttctc tgggtgggtc    540

cagcacagaa gaggttcagt acacctgtgc tgtactaagg tggtgaatta ttcaatgagc    600

attctaaatt tcagaaacat attggaaaca gtatacccag acagtatcca agtgttggaa    660

atttggaaca tgtgctggcc gtgtatgata gtagagttta tccgttacct gagccagatg    720

aggaatcttc gcaaactctt catctccgat ggctgtcgtt acctgctaag ctctgacagc    780

caagaacagt tagttgctga attcagctct gtgctcctca ggctggagta cctccagatg    840

ctttatgtaa gaagggtctg cttcttcaga ggccacctgg accagctgat caggtgcctc    900

aggagcccat tggagacatt ggcattaact tatggcttcc tagaaaaagt ggacttgaaa    960

tgtctgcccc ggtacccaag tctcagtcaa ctgaagcagc tgaatctgag tcatggtgca   1020

ctgcgcttca tccgtcttga gcccctccga gctctgctag agaaagttgc tgccactctt   1080

cagaccctct tcttagtgga ctgtgggatt cgggactcca aactcagggt catcctgcct   1140

gccctgagct gctgctccaa cctcaccact ttctgttttc acggcaatga cacgtccatg   1200

gatggtctga aggacctgct gcgccacaca ggcaggctga gcaatttgag cctggaaaca   1260

tatcctgccc ctcgggagag tcttgatgac aggggtcgtg tcatttcgga gctcctcacc   1320

ccacttcagg ctgagctgat gcgtatactg agggaagtaa gggagcccaa aaggatcttc   1380

tttggtccgg tgtcctgccc ttgctgtggc acgtcgccca ctgagcaact ggagttcaat   1440

ttttgcttgt ggggaaggcc tgcctagtgg ggtggaggta taaaaagctt tttctccagg   1500

cacttggaaa ctaaaatctg ggacatagat gtcttttatt tttctttttc cttattttac   1560

aattttacag tttttattta aaaatttgag acagggtttc cctatgttgt ccaggctggt   1620

ctcaaactct tacgcttaag ggagccacct gcttggcctc ccaagattct gggattacag   1680

gcataagcag ctgtgccggg tctataggtg tattataaag ggagcagaga aacctctgtt   1740

tcaggcatgt gctttctgtg agtgggaaaa aaaacacaaa aaaacccagc agggggcagc   1800

actggggaaa aggttgaatg gagtcactga gactcaggga tctgtgtcct agacagtcag   1860

aaatagaaag ctgaagttct agagtgaagg agttatctca gcaaggatgg atacaaagaa   1920

acgtcggaag tagagggaac ctaaatggaa actctctgct gtccttcatg attgattagc   1980

ctgtttcagc aatttataca tcagaaatct ttagttcctg atgaattaaa aaaagaggta   2040

ctagttcatc tgtgatttag gttcatctgc aggaaataaa ggaatcaaaa taaacttcat   2100

tttg                                                                2104


<210>  1506
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  1506

Met Arg Met Ser Leu Gln Ala Pro Arg Arg Leu Leu Glu Leu Ala Gly 
1               5                   10                  15


Gln Ser Leu Leu Gly Asp Gln Ala Leu Ala Ile Ser Ile Leu Asp Glu 
            20                  25                  30


Leu Pro Arg Glu Leu Phe Pro Pro Leu Phe Val Glu Ala Phe Thr Ser 
        35                  40                  45


Arg Arg Cys Glu Val Leu Lys Val Met Val Gln Ala Trp Pro Phe Pro 
    50                  55                  60


Cys Leu Pro Leu Gly Ser Leu Met Lys Thr Pro Asp Leu Glu Ile Leu 
65                  70                  75                  80


His Tyr Val Val Asp Gly Ile Asp Cys Leu Leu Ala Gln Lys Val Arg 
                85                  90                  95


Pro Arg Arg Arg Lys Leu Gln Val Leu Glu Leu Arg Asp Val Asp Glu 
            100                 105                 110


Asn Phe Trp Thr Ile Trp Ser Gly Ala Arg Pro Leu Ser Cys Ser Pro 
        115                 120                 125


Glu Ala Met Ser Lys Arg Gln Thr Val Glu Asp Cys Pro Arg Thr Gly 
    130                 135                 140


Glu Lys Gln Pro Leu Lys Val Phe Met Asp Val Cys Leu Lys Glu Lys 
145                 150                 155                 160


Phe Met Asp Glu Asp Leu Ser Phe Phe Ser Gly Trp Val Gln His Arg 
                165                 170                 175


Arg Gly Ser Val His Leu Cys Cys Thr Lys Val Val Asn Tyr Ser Met 
            180                 185                 190


Ser Ile Leu Asn Phe Arg Asn Ile Leu Glu Thr Val Tyr Pro Asp Ser 
        195                 200                 205


Ile Gln Val Leu Glu Ile Trp Asn Met Cys Trp Pro Cys Met Ile Val 
    210                 215                 220


Glu Phe Ile Arg Tyr Leu Ser Gln Met Arg Asn Leu Arg Lys Leu Phe 
225                 230                 235                 240


Ile Ser Asp Gly Cys Arg Tyr Leu Leu Ser Ser Asp Ser Gln Glu Gln 
                245                 250                 255


Leu Val Ala Glu Phe Ser Ser Val Leu Leu Arg Leu Glu Tyr Leu Gln 
            260                 265                 270


Met Leu Tyr Val Arg Arg Val Cys Phe Phe Arg Gly His Leu Asp Gln 
        275                 280                 285


Leu Ile Arg Cys Leu Arg Ser Pro Leu Glu Thr Leu Ala Leu Thr Tyr 
    290                 295                 300


Gly Phe Leu Glu Lys Val Asp Leu Lys Cys Leu Pro Arg Tyr Pro Ser 
305                 310                 315                 320


Leu Ser Gln Leu Lys Gln Leu Asn Leu Ser His Gly Ala Leu Arg Phe 
                325                 330                 335


Ile Arg Leu Glu Pro Leu Arg Ala Leu Leu Glu Lys Val Ala Ala Thr 
            340                 345                 350


Leu Gln Thr Leu Phe Leu Val Asp Cys Gly Ile Arg Asp Ser Lys Leu 
        355                 360                 365


Arg Val Ile Leu Pro Ala Leu Ser Cys Cys Ser Asn Leu Thr Thr Phe 
    370                 375                 380


Cys Phe His Gly Asn Asp Thr Ser Met Asp Gly Leu Lys Asp Leu Leu 
385                 390                 395                 400


Arg His Thr Gly Arg Leu Ser Asn Leu Ser Leu Glu Thr Tyr Pro Ala 
                405                 410                 415


Pro Arg Glu Ser Leu Asp Asp Arg Gly Arg Val Ile Ser Glu Leu Leu 
            420                 425                 430


Thr Pro Leu Gln Ala Glu Leu Met Arg Ile Leu Arg Glu Val Arg Glu 
        435                 440                 445


Pro Lys Arg Ile Phe Phe Gly Pro Val Ser Cys Pro Cys Cys Gly Thr 
    450                 455                 460


Ser Pro Thr Glu Gln Leu Glu Phe Asn Phe Cys Leu Trp Gly Arg Pro 
465                 470                 475                 480


Ala 



<210>  1507
<211>  1855
<212>  DNA
<213>  Homo sapiens

<400>  1507
acccaaagtc ttcaagcctg gagttcctgc ttggttcttc ctgaggactg agcaccttct     60

agactacatc cagatctgtt ttccctgcag attcgtgaag atgagcatcc ggactccacc    120

cagactcctg gagcttgcag ggcggagcct gctgagggac caagccttgg ccatgtccac    180

cctggaggag ctgcccacag aacttttccc cccactgttc atggaggcct tcagcaggag    240

acgctgtgag gccctgaagc tgatggtgca ggcctggccc ttccgccgcc tccctctgag    300

gcctctgata aagatgcctt gtctggaggc cttccaagct gtgctcgatg ggctggatgc    360

actgcttacc caaggggttc atcccaggag gtggaaactt caagtgctgg atttacagga    420

tgtctgtgag aacttctgga tggtttggtc tgaagctatg gcccatgggt gcttcctcaa    480

tgccaagagg aacaaaaaac cagtgcagga ctgtccaagg atgagaggac agcagccctt    540

gactgtgttc gtagaacttt ggctcaagaa caggactctg gatgaatacc tcacctgcct    600

ccttctatgg gtcaagcaga ggaaagattt actacacctg tgctgtaaga agctgaaaat    660

tttgggaatg cccttccgca atatcagaag catcctgaaa atggtgaacc tagactgtat    720

ccaggaggtg gaagtgaatt gcaagtgggt actgcccatc ctgacacagt ttaccccata    780

cctgggccac atgaggaatc ttcagaagct cgttctctcc cacatggatg tctctcgcta    840

cgtttcccca gagcagaaga aggagattgt tacccagttc accactcagt tcctcaagct    900

gtgctgcctc caaaagcttt ctatgaactc tgtttctttc ctcgaaggcc acctggacca    960

gctgctcagc tgtctgaaga cctcgttaaa ggtcctcaca ataactaact gtgtgctttt   1020

ggaatcagac ttgaagcatc tatcccagtg cccgagtatc agtcaactaa agaccctgga   1080

cctgagtggc atcagactga ccaattacag tcttgtgcct ctccaaattc tcctagaaaa   1140

agttgcagcc acccttgagt acctggattt agatgactgt ggcatcatag actcccaagt   1200

caacgccatc ctgcctgccc tgagccgctg ctttgagctc aacaccttca gcttctgtgg   1260

aaatcccatc tccatggcca ccctggagaa cctgctgagc cacacaatca tactcaaaaa   1320

cttatgcgtg gagctgtatc ctgccccccg ggagagttat gatgctgatg gtactctctg   1380

ctggagcaga tttgctcaaa ttagggctga gctgatgaag agagtgaggg acttaaggca   1440

ccccaagagg atcttgttct gtactgactg ctgccctgac tgtggcaaca ggtcatttta   1500

tgacctggag gcagatcaat gctgctgttg aatgcctgcc tatttgggtg gatatgtcaa   1560

acgctttctt ctggacactt ggaaactaaa acctaggtct taggtacatc ctatagggag   1620

cacagaaccc atcatttcac acatgggctc tgaaagtggg aaaggaaagg tgatcaagca   1680

ggggcaggac ttgggggaag tgttgccatg gattcgatgg gactttgggg acctgtgtcc   1740

tgtagagtgg aaaatgggaa tttgaatgtc tagagtggag gcttgagaat acttgaggga   1800

gttactcttg gatgcatggt tgtaaagaaa caatcagaaa taaaggaaaa ctgag        1855


<210>  1508
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  1508

Met Ser Ile Arg Thr Pro Pro Arg Leu Leu Glu Leu Ala Gly Arg Ser 
1               5                   10                  15


Leu Leu Arg Asp Gln Ala Leu Ala Met Ser Thr Leu Glu Glu Leu Pro 
            20                  25                  30


Thr Glu Leu Phe Pro Pro Leu Phe Met Glu Ala Phe Ser Arg Arg Arg 
        35                  40                  45


Cys Glu Ala Leu Lys Leu Met Val Gln Ala Trp Pro Phe Arg Arg Leu 
    50                  55                  60


Pro Leu Arg Pro Leu Ile Lys Met Pro Cys Leu Glu Ala Phe Gln Ala 
65                  70                  75                  80


Val Leu Asp Gly Leu Asp Ala Leu Leu Thr Gln Gly Val His Pro Arg 
                85                  90                  95


Arg Trp Lys Leu Gln Val Leu Asp Leu Gln Asp Val Cys Glu Asn Phe 
            100                 105                 110


Trp Met Val Trp Ser Glu Ala Met Ala His Gly Cys Phe Leu Asn Ala 
        115                 120                 125


Lys Arg Asn Lys Lys Pro Val Gln Asp Cys Pro Arg Met Arg Gly Gln 
    130                 135                 140


Gln Pro Leu Thr Val Phe Val Glu Leu Trp Leu Lys Asn Arg Thr Leu 
145                 150                 155                 160


Asp Glu Tyr Leu Thr Cys Leu Leu Leu Trp Val Lys Gln Arg Lys Asp 
                165                 170                 175


Leu Leu His Leu Cys Cys Lys Lys Leu Lys Ile Leu Gly Met Pro Phe 
            180                 185                 190


Arg Asn Ile Arg Ser Ile Leu Lys Met Val Asn Leu Asp Cys Ile Gln 
        195                 200                 205


Glu Val Glu Val Asn Cys Lys Trp Val Leu Pro Ile Leu Thr Gln Phe 
    210                 215                 220


Thr Pro Tyr Leu Gly His Met Arg Asn Leu Gln Lys Leu Val Leu Ser 
225                 230                 235                 240


His Met Asp Val Ser Arg Tyr Val Ser Pro Glu Gln Lys Lys Glu Ile 
                245                 250                 255


Val Thr Gln Phe Thr Thr Gln Phe Leu Lys Leu Cys Cys Leu Gln Lys 
            260                 265                 270


Leu Ser Met Asn Ser Val Ser Phe Leu Glu Gly His Leu Asp Gln Leu 
        275                 280                 285


Leu Ser Cys Leu Lys Thr Ser Leu Lys Val Leu Thr Ile Thr Asn Cys 
    290                 295                 300


Val Leu Leu Glu Ser Asp Leu Lys His Leu Ser Gln Cys Pro Ser Ile 
305                 310                 315                 320


Ser Gln Leu Lys Thr Leu Asp Leu Ser Gly Ile Arg Leu Thr Asn Tyr 
                325                 330                 335


Ser Leu Val Pro Leu Gln Ile Leu Leu Glu Lys Val Ala Ala Thr Leu 
            340                 345                 350


Glu Tyr Leu Asp Leu Asp Asp Cys Gly Ile Ile Asp Ser Gln Val Asn 
        355                 360                 365


Ala Ile Leu Pro Ala Leu Ser Arg Cys Phe Glu Leu Asn Thr Phe Ser 
    370                 375                 380


Phe Cys Gly Asn Pro Ile Ser Met Ala Thr Leu Glu Asn Leu Leu Ser 
385                 390                 395                 400


His Thr Ile Ile Leu Lys Asn Leu Cys Val Glu Leu Tyr Pro Ala Pro 
                405                 410                 415


Arg Glu Ser Tyr Asp Ala Asp Gly Thr Leu Cys Trp Ser Arg Phe Ala 
            420                 425                 430


Gln Ile Arg Ala Glu Leu Met Lys Arg Val Arg Asp Leu Arg His Pro 
        435                 440                 445


Lys Arg Ile Leu Phe Cys Thr Asp Cys Cys Pro Asp Cys Gly Asn Arg 
    450                 455                 460


Ser Phe Tyr Asp Leu Glu Ala Asp Gln Cys Cys Cys 
465                 470                 475


<210>  1509
<211>  832
<212>  DNA
<213>  Homo sapiens

<400>  1509
atgagtaaga ggcagacagc agaggactat ccaaggatgg gagagcacca gcccttaaag     60

gtgttcatag acgtctgcct caaggaaaca ccccaagatg aatgcctgag atacctcttc    120

cagctggaac acctccaatt gcttaaagta aaattgatca ccttcttcag tgggcacctg    180

gaacagctga tcaggtgcct ccagaacccc ttggagaact tggagttaac ttgtggctac    240

ctattggaag aagacatgaa gtgtctgtct cagtacccaa gcctcagcta cctaaagcat    300

ctgaatctca gctacgtgct gctgttccgc atcagtcttg aacccctcgg agctctgcta    360

gagaaaattg ctgccactct caagaccctc atcttcgagg gctgtcagat ccactactgc    420

caactcagcg ccatcctgcc tggcctgagc cgctgctccc agctcaccac cttctacttt    480

ggcagaaatt gcatgtctac ggacaccctg aaggacctgc tgcgccacac cagtgggctg    540

agcaagttaa gcctggagac gtatcctgcc cctgaggaga gtttgaattc cttggttcgt    600

gtcgattggg agatcttcgc cccactttgg gctgagctga tgtgtacact gagggaagtc    660

aggcagccca agaggatctt cactggtccc actccctgcc cttcctgtgg ctcatcaccg    720

tctgaggaac tggagctcca tctttgctgc tagggaaggc gtgcctagtg gggttgataa    780

atccaaagtt ctcttccagg cacttggaca ctaaaatcta gtatgtaagt gc            832


<210>  1510
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  1510

Met Ser Lys Arg Gln Thr Ala Glu Asp Tyr Pro Arg Met Gly Glu His 
1               5                   10                  15


Gln Pro Leu Lys Val Phe Ile Asp Val Cys Leu Lys Glu Thr Pro Gln 
            20                  25                  30


Asp Glu Cys Leu Arg Tyr Leu Phe Gln Leu Glu His Leu Gln Leu Leu 
        35                  40                  45


Lys Val Lys Leu Ile Thr Phe Phe Ser Gly His Leu Glu Gln Leu Ile 
    50                  55                  60


Arg Cys Leu Gln Asn Pro Leu Glu Asn Leu Glu Leu Thr Cys Gly Tyr 
65                  70                  75                  80


Leu Leu Glu Glu Asp Met Lys Cys Leu Ser Gln Tyr Pro Ser Leu Ser 
                85                  90                  95


Tyr Leu Lys His Leu Asn Leu Ser Tyr Val Leu Leu Phe Arg Ile Ser 
            100                 105                 110


Leu Glu Pro Leu Gly Ala Leu Leu Glu Lys Ile Ala Ala Thr Leu Lys 
        115                 120                 125


Thr Leu Ile Phe Glu Gly Cys Gln Ile His Tyr Cys Gln Leu Ser Ala 
    130                 135                 140


Ile Leu Pro Gly Leu Ser Arg Cys Ser Gln Leu Thr Thr Phe Tyr Phe 
145                 150                 155                 160


Gly Arg Asn Cys Met Ser Thr Asp Thr Leu Lys Asp Leu Leu Arg His 
                165                 170                 175


Thr Ser Gly Leu Ser Lys Leu Ser Leu Glu Thr Tyr Pro Ala Pro Glu 
            180                 185                 190


Glu Ser Leu Asn Ser Leu Val Arg Val Asp Trp Glu Ile Phe Ala Pro 
        195                 200                 205


Leu Trp Ala Glu Leu Met Cys Thr Leu Arg Glu Val Arg Gln Pro Lys 
    210                 215                 220


Arg Ile Phe Thr Gly Pro Thr Pro Cys Pro Ser Cys Gly Ser Ser Pro 
225                 230                 235                 240


Ser Glu Glu Leu Glu Leu His Leu Cys Cys 
                245                 250


<210>  1511
<211>  1844
<212>  DNA
<213>  Homo sapiens

<400>  1511
gaactactgc ttgattctct gagagatccc agcaccctac aaactgagtc cagatctgag     60

ttttcccttg cagattcatc aagatgagca tcagggcccc acccagactc ctggagctgg    120

caaggcagag gctgctgagg gaccaggcct tggccatctc caccatggag gagctgccca    180

gggagctctt ccccacactg ttcatggagg ccttcagcag gagacgctgt gaaaccctga    240

aaacaatggt gcaggcctgg cctttcaccc gcctccctct agggtccctg atgaagtcgc    300

ctcatctgga gtcattaaaa tctgtgctgg aaggggttga tgtgctgttg acccaagagg    360

ttcgccccag gcagtcaaaa cttcaagtgc tggacttgag gaatgtggat gagaacttct    420

gcgacatatt ttctggagct actgcatcct tcccggaggc tctgagtcag aagcaaacag    480

cagataactg tccagggaca ggcaggcagc agccattcat ggtgttcata gacctttgtc    540

tcaagaacag gacactagat gaatgcctca cccacctctt agagtggggc aagcagagaa    600

aaggcttact gcatgtgtgt tgccaggagc tgcaggtttt tggaatgccc atccacagta    660

tcatagaggt cctgaacatg gtggagcttg actgtatcca ggaggtggaa gtgtgctgcc    720

cctgggagct gtccactctt gtgaagtttg ccccttacct gggccagatg aggaatctcc    780

gcaaacttgt tctcttcaac atccgtgcat ctgcctgcat tcccccagac aacaaggggc    840

agttcattgc ccgattcacc tctcagttcc tcaagctgga ctatttccag aatctgtcta    900

tgcactccgt ctctttcctc gaaggccacc tggaccagct gctcaggtgt ctccaggcct    960

ccttggagat ggtcgttatg accgactgcc tgctgtcaga gtcggacttg aagcatctct   1020

cttggtgccc gagcatccgt caattaaagg agctggacct gaggggtgtc acactgaccc   1080

atttcagccc tgagcccctc acaggtctgc tggagcaagt tgtggccacc ctgcagaccc   1140

tggacttaga ggactgtggg atcatggatt cccaactcag cgccatcctg cctgtcctga   1200

gccgctgctc ccagctcagc accttcagct tctgtgggaa cctcatctcc atggctgccc   1260

ttgagaacct gctgcgccac accgtcgggc tgagcaagct aagcctggag ctgtatcctg   1320

cccctctgga gagttatgac acccagggtg ctctctgctg ggggagattt gctgaacttg   1380

gggctgagct gatgaagaca ctgagggact taaggcagcc caagatcatt gtgttctgca   1440

ccgtcccctg ccctcgctgt ggcatcaggg cctcctatga cctggagccc agtcactgcc   1500

tctgttgaat gcctgccatc agggtggata tatttcaagc tttcttctgg tcatttcgga   1560

gctgaaacct aggccatgag tgcatgttaa agggagcaca gacccatcgt ttcaaatgcc   1620

tcctcagtgt gaatgggaaa ggaatgagga tgcaggaggg gcaggactgg gggaaaagtt   1680

gacttggagt ggatgggctc tttagagacc tgtgtcccag agaatcagaa atgggaatct   1740

gaattgctag agtgagaatc agggaggaga gacacatgag agggttaccc ctgcacagat   1800

ggttgtaaag taacagtcag aaataaaggg aaactgagtg gaaa                    1844


<210>  1512
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  1512

Met Ser Ile Arg Ala Pro Pro Arg Leu Leu Glu Leu Ala Arg Gln Arg 
1               5                   10                  15


Leu Leu Arg Asp Gln Ala Leu Ala Ile Ser Thr Met Glu Glu Leu Pro 
            20                  25                  30


Arg Glu Leu Phe Pro Thr Leu Phe Met Glu Ala Phe Ser Arg Arg Arg 
        35                  40                  45


Cys Glu Thr Leu Lys Thr Met Val Gln Ala Trp Pro Phe Thr Arg Leu 
    50                  55                  60


Pro Leu Gly Ser Leu Met Lys Ser Pro His Leu Glu Ser Leu Lys Ser 
65                  70                  75                  80


Val Leu Glu Gly Val Asp Val Leu Leu Thr Gln Glu Val Arg Pro Arg 
                85                  90                  95


Gln Ser Lys Leu Gln Val Leu Asp Leu Arg Asn Val Asp Glu Asn Phe 
            100                 105                 110


Cys Asp Ile Phe Ser Gly Ala Thr Ala Ser Phe Pro Glu Ala Leu Ser 
        115                 120                 125


Gln Lys Gln Thr Ala Asp Asn Cys Pro Gly Thr Gly Arg Gln Gln Pro 
    130                 135                 140


Phe Met Val Phe Ile Asp Leu Cys Leu Lys Asn Arg Thr Leu Asp Glu 
145                 150                 155                 160


Cys Leu Thr His Leu Leu Glu Trp Gly Lys Gln Arg Lys Gly Leu Leu 
                165                 170                 175


His Val Cys Cys Gln Glu Leu Gln Val Phe Gly Met Pro Ile His Ser 
            180                 185                 190


Ile Ile Glu Val Leu Asn Met Val Glu Leu Asp Cys Ile Gln Glu Val 
        195                 200                 205


Glu Val Cys Cys Pro Trp Glu Leu Ser Thr Leu Val Lys Phe Ala Pro 
    210                 215                 220


Tyr Leu Gly Gln Met Arg Asn Leu Arg Lys Leu Val Leu Phe Asn Ile 
225                 230                 235                 240


Arg Ala Ser Ala Cys Ile Pro Pro Asp Asn Lys Gly Gln Phe Ile Ala 
                245                 250                 255


Arg Phe Thr Ser Gln Phe Leu Lys Leu Asp Tyr Phe Gln Asn Leu Ser 
            260                 265                 270


Met His Ser Val Ser Phe Leu Glu Gly His Leu Asp Gln Leu Leu Arg 
        275                 280                 285


Cys Leu Gln Ala Ser Leu Glu Met Val Val Met Thr Asp Cys Leu Leu 
    290                 295                 300


Ser Glu Ser Asp Leu Lys His Leu Ser Trp Cys Pro Ser Ile Arg Gln 
305                 310                 315                 320


Leu Lys Glu Leu Asp Leu Arg Gly Val Thr Leu Thr His Phe Ser Pro 
                325                 330                 335


Glu Pro Leu Thr Gly Leu Leu Glu Gln Val Val Ala Thr Leu Gln Thr 
            340                 345                 350


Leu Asp Leu Glu Asp Cys Gly Ile Met Asp Ser Gln Leu Ser Ala Ile 
        355                 360                 365


Leu Pro Val Leu Ser Arg Cys Ser Gln Leu Ser Thr Phe Ser Phe Cys 
    370                 375                 380


Gly Asn Leu Ile Ser Met Ala Ala Leu Glu Asn Leu Leu Arg His Thr 
385                 390                 395                 400


Val Gly Leu Ser Lys Leu Ser Leu Glu Leu Tyr Pro Ala Pro Leu Glu 
                405                 410                 415


Ser Tyr Asp Thr Gln Gly Ala Leu Cys Trp Gly Arg Phe Ala Glu Leu 
            420                 425                 430


Gly Ala Glu Leu Met Lys Thr Leu Arg Asp Leu Arg Gln Pro Lys Ile 
        435                 440                 445


Ile Val Phe Cys Thr Val Pro Cys Pro Arg Cys Gly Ile Arg Ala Ser 
    450                 455                 460


Tyr Asp Leu Glu Pro Ser His Cys Leu Cys 
465                 470


<210>  1513
<211>  291
<212>  DNA
<213>  Homo sapiens

<400>  1513
atgagcctcc aggccccatc cagactgctg gagctggcag ggcagagcct gctgaggaac     60

cagttcttga ccatcttcac cctggatgag ctgcccaggg aggtcttccc tctgatgttc    120

atggaggcct tcagcatgag acgttttgag gccctgaagc tgatggtgca ggcctggccc    180

ttcctccgcc tccctctggg atccctgatg aagacacctc atctggagac cttgcaagct    240

gtcctgaggg gacttgatac actggtggcc cagaaggttc gccccaggtg a             291


<210>  1514
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  1514

Met Ser Leu Gln Ala Pro Ser Arg Leu Leu Glu Leu Ala Gly Gln Ser 
1               5                   10                  15


Leu Leu Arg Asn Gln Phe Leu Thr Ile Phe Thr Leu Asp Glu Leu Pro 
            20                  25                  30


Arg Glu Val Phe Pro Leu Met Phe Met Glu Ala Phe Ser Met Arg Arg 
        35                  40                  45


Phe Glu Ala Leu Lys Leu Met Val Gln Ala Trp Pro Phe Leu Arg Leu 
    50                  55                  60


Pro Leu Gly Ser Leu Met Lys Thr Pro His Leu Glu Thr Leu Gln Ala 
65                  70                  75                  80


Val Leu Arg Gly Leu Asp Thr Leu Val Ala Gln Lys Val Arg Pro Arg 
                85                  90                  95


<210>  1515
<211>  1871
<212>  DNA
<213>  Homo sapiens

<400>  1515
caggagagac ccaaagtctt caagcctgga gttcctgctt ggttcttcct gaggtctgag     60

caccttctag actacatcca gatctgtttt ccctgcagat tcatgaagat gagcatccgg    120

actccaccca gactcctgga gcttgcaggg cggagcctgc tgagggacca agctttggcc    180

atgtccaccc tggaggagct gcccacagaa cttttccccc cactgttcat ggaggccttc    240

agcaggagac gctgtgaggc cctgaagctg atggtgcagg cctggccctt ccgccgcctc    300

cctctgaggc ctctgataaa gatgccttgt ctggaggcct tccaagctgt gctcgatggg    360

cttgatgcac tgcttaccca aggggttcgt cccaggaggt ggaaactcca agtgctggat    420

ttacaggatg tctgtgagaa cttctggatg gtttggtctg aagctatggc ccatgggtgc    480

ttcctcaatg ccaagaggaa caaaaaacca gtgcaggact gtccaaggat gagaggacgg    540

cagcccttga ctgtgttcgt agaactttgg ctcaagaaca ggactctgga tgaatacctc    600

acctacctcc ttctatgggt caagcagagg aaagatttac tacacctgtg ctgtaagaag    660

ctgaaaattt tgggaatgcc cttccgcaat atcagaagca tcctgaaaat ggtgaaccta    720

gactgtatcc aggaggtgga agtgaattgc aagtgggtac tgcccatcct gacacagttt    780

accccatacc tgggccacat gaggaatctt cagaagctcg ttctctccca catggatgtc    840

tctcgctacg tttccccaga gcagaagaag gagattgtta cccagttcac cactcagttc    900

ctcaagctgc gctgcctcca aaagctttat atgaactctg tttctttcct cgaaggccac    960

ctggaccagc tgctcagctg tctgaagacc tcgttaaaag tcctcacaat aactaactgt   1020

gtgcttttgg aatcagactt gaagcatcta tcccagtgcc cgagtatcag tcaactaaag   1080

accctggacc tgagtggcat cagactgacc aattatagtc ttgtgcctct ccaaattctc   1140

ctagaaaaag ttgcagccac ccttgagtac ctggatttag atgactgtgg catcatagac   1200

tcccaagtca acgccatcct gcctgccctg agccgctgct ttgagctcaa caccttcagc   1260

ttctgtggaa atcccatctg catggccacc ctggagaacc tgctgagcca cacaatcata   1320

ctcaaaaact tatgtgtgga gctgtatcct gccccccgag agagttatgg tgctgatggt   1380

actctctgct ggagcagatt tgctcaaatt agggctgagc tgatgaacag agtgagggac   1440

ttaaggcacc ccaagaggat cttgttctgt actgactact gccctgactg tggcaacagg   1500

tcattttatg acctggaggc agatcaatac tgctgttgaa tgcctgccta tttggatggg   1560

tatgtcaaac gctttcttct ggacacttgg aaactaaaac ctaggtctta ggtacatcct   1620

aaagggagca cagaacccat catttcacac ataggctctg aaagtgggaa aggaaagctg   1680

atcaagcagg ggccggactt gggggaaatg ttgccatgga ttcgatggga ctttggggac   1740

ctgtgtcctg tagattcgaa aatgggaatc tgaatgtcta gagtggaatt caggcttgag   1800

aatacatgag ggagttactc ttgcatggat ggttgtaaag aaacaatcag aaataaagga   1860

aaactgagca g                                                        1871


<210>  1516
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  1516

Met Lys Met Ser Ile Arg Thr Pro Pro Arg Leu Leu Glu Leu Ala Gly 
1               5                   10                  15


Arg Ser Leu Leu Arg Asp Gln Ala Leu Ala Met Ser Thr Leu Glu Glu 
            20                  25                  30


Leu Pro Thr Glu Leu Phe Pro Pro Leu Phe Met Glu Ala Phe Ser Arg 
        35                  40                  45


Arg Arg Cys Glu Ala Leu Lys Leu Met Val Gln Ala Trp Pro Phe Arg 
    50                  55                  60


Arg Leu Pro Leu Arg Pro Leu Ile Lys Met Pro Cys Leu Glu Ala Phe 
65                  70                  75                  80


Gln Ala Val Leu Asp Gly Leu Asp Ala Leu Leu Thr Gln Gly Val Arg 
                85                  90                  95


Pro Arg Arg Trp Lys Leu Gln Val Leu Asp Leu Gln Asp Val Cys Glu 
            100                 105                 110


Asn Phe Trp Met Val Trp Ser Glu Ala Met Ala His Gly Cys Phe Leu 
        115                 120                 125


Asn Ala Lys Arg Asn Lys Lys Pro Val Gln Asp Cys Pro Arg Met Arg 
    130                 135                 140


Gly Arg Gln Pro Leu Thr Val Phe Val Glu Leu Trp Leu Lys Asn Arg 
145                 150                 155                 160


Thr Leu Asp Glu Tyr Leu Thr Tyr Leu Leu Leu Trp Val Lys Gln Arg 
                165                 170                 175


Lys Asp Leu Leu His Leu Cys Cys Lys Lys Leu Lys Ile Leu Gly Met 
            180                 185                 190


Pro Phe Arg Asn Ile Arg Ser Ile Leu Lys Met Val Asn Leu Asp Cys 
        195                 200                 205


Ile Gln Glu Val Glu Val Asn Cys Lys Trp Val Leu Pro Ile Leu Thr 
    210                 215                 220


Gln Phe Thr Pro Tyr Leu Gly His Met Arg Asn Leu Gln Lys Leu Val 
225                 230                 235                 240


Leu Ser His Met Asp Val Ser Arg Tyr Val Ser Pro Glu Gln Lys Lys 
                245                 250                 255


Glu Ile Val Thr Gln Phe Thr Thr Gln Phe Leu Lys Leu Arg Cys Leu 
            260                 265                 270


Gln Lys Leu Tyr Met Asn Ser Val Ser Phe Leu Glu Gly His Leu Asp 
        275                 280                 285


Gln Leu Leu Ser Cys Leu Lys Thr Ser Leu Lys Val Leu Thr Ile Thr 
    290                 295                 300


Asn Cys Val Leu Leu Glu Ser Asp Leu Lys His Leu Ser Gln Cys Pro 
305                 310                 315                 320


Ser Ile Ser Gln Leu Lys Thr Leu Asp Leu Ser Gly Ile Arg Leu Thr 
                325                 330                 335


Asn Tyr Ser Leu Val Pro Leu Gln Ile Leu Leu Glu Lys Val Ala Ala 
            340                 345                 350


Thr Leu Glu Tyr Leu Asp Leu Asp Asp Cys Gly Ile Ile Asp Ser Gln 
        355                 360                 365


Val Asn Ala Ile Leu Pro Ala Leu Ser Arg Cys Phe Glu Leu Asn Thr 
    370                 375                 380


Phe Ser Phe Cys Gly Asn Pro Ile Cys Met Ala Thr Leu Glu Asn Leu 
385                 390                 395                 400


Leu Ser His Thr Ile Ile Leu Lys Asn Leu Cys Val Glu Leu Tyr Pro 
                405                 410                 415


Ala Pro Arg Glu Ser Tyr Gly Ala Asp Gly Thr Leu Cys Trp Ser Arg 
            420                 425                 430


Phe Ala Gln Ile Arg Ala Glu Leu Met Asn Arg Val Arg Asp Leu Arg 
        435                 440                 445


His Pro Lys Arg Ile Leu Phe Cys Thr Asp Tyr Cys Pro Asp Cys Gly 
    450                 455                 460


Asn Arg Ser Phe Tyr Asp Leu Glu Ala Asp Gln Tyr Cys Cys 
465                 470                 475


<210>  1517
<211>  2088
<212>  DNA
<213>  Homo sapiens

<400>  1517
tcttgcagat ttatcaggat gagcttccag gccccacgca gactcctgga gctggcaggg     60

cagagcctgc tgagggacca ggccttggcc atctccgtcc tggatgagct gcccagggag    120

ctcttccccc gactgttcgt ggaggccttc actagcagac gctgcgaggt tctgaaggtg    180

atggtgcagg cctggccctt cccctgcctc cctctggggt ccctgatgaa gacgcctgat    240

ctggagatct tacattatgt agtggatggg attgattgcc tgcttgccca aaaggttcgc    300

cccaggaggt ggaaacttca agtgctggaa atgcgggatg ttgatgagaa tttttggacc    360

atatggtctg gagccaggcc cctgtcctgc tccccagagg ccatgagtaa gagacagaca    420

gtggaggact gtccaaggac aggagagaag cagcccttga aggtgttcat ggatgtttgc    480

ctcaaggaaa aatccgtgga tgaagatctg agcttcttct ctgggtgggt gcagcacaga    540

agacgttcag tacacctgtg ctgtactaag gtggtaaatt attcaatgaa cattctaaat    600

ttcagaaaca tattagaaac agtataccca gacagtatcc aagtattgga aatttggaac    660

atgtgctggc cgtgtatggt agcagaggtt agccgttacc tgagccagat gaagaatctt    720

cgaaaactct tcatctccga tggctgtggt tacctgccaa gctttgagag ccaaggacag    780

ttagttgctg aattcagctc tgtgttcctc aggctggagt acctccagat gctttatatg    840

agaaggatcc gcttcttcga aggctacctg gaccagctga tcaggtgcct caagagcccg    900

ttggagacat tggcattaac ttatggctcc ctagatgaag aggacttgaa atgtctgccc    960

tggtacccaa gtctcagtca actgaagcag ctgaatctga gtcatggtac actgcgcttc   1020

atccgtcttg agcccctccg agctctgcta gagaaagttg ctgccactct tcagaccctc   1080

ttcttagtgg actgtgggat tggggactcc aaactcaggg tcatcctgcc tgccctgagc   1140

cgctgctcca acctcaccac tttctgcttt cacggcaatg acacgtccat ggatggtctg   1200

aaggacctgc tgcgccacac aggcaggctg agcaatttga gcctggaaac atatcctgcc   1260

cctcgggaga gtcttgacaa caggggtcgt gtcatttcgg agctcctcac cccacttcag   1320

gctgagctga tgcgtatact gagggaagta agggagccca acaggatctt ctttggtccc   1380

gtctcctgcc cttgctgtgg catgtcaccc actgagcaac tggagttcaa tttttgcttg   1440

cggggaaggc ctgcctagtg gggtggaggt ataaaaagct ttttctccag gcacttggaa   1500

actaaaatct aggacataga tatcttttat ttttcttttt ccttatttta caattttaca   1560

gcttttattt aaaaatttga gacagggttt ccctatgttg tccaggctgg tctcaaactc   1620

ttacgcttaa gggagccccc tgcttggcct cccaagattc tgggattaca ggcataagca   1680

gctgtgccgg gtctataggt gtattataaa gggagcagag aaacctctgt ttcaggcatg   1740

tgctttctgt gagtgggaaa aaaaacacaa aaaaacccag cagggggcag cactggggaa   1800

aaggttgaat ggagtcactg agactcaggg atctgtgtcc tagacagtca gaaatagaac   1860

ctgaagttct agagtgaagg agttatctca gcaaggatgg atacaaagaa acgtcggaag   1920

taaagggaac ctaaatggaa actctctgct gtccttcatg attgattagc ctgtttcagc   1980

aatttataca tcagaaatct ttagttcctg atgaattaaa aaaagaggta ctagttcatc   2040

tgtgatttaa gttcatccgc aggaaataaa ggaatcaaaa taaacttc                2088


<210>  1518
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  1518

Met Ser Phe Gln Ala Pro Arg Arg Leu Leu Glu Leu Ala Gly Gln Ser 
1               5                   10                  15


Leu Leu Arg Asp Gln Ala Leu Ala Ile Ser Val Leu Asp Glu Leu Pro 
            20                  25                  30


Arg Glu Leu Phe Pro Arg Leu Phe Val Glu Ala Phe Thr Ser Arg Arg 
        35                  40                  45


Cys Glu Val Leu Lys Val Met Val Gln Ala Trp Pro Phe Pro Cys Leu 
    50                  55                  60


Pro Leu Gly Ser Leu Met Lys Thr Pro Asp Leu Glu Ile Leu His Tyr 
65                  70                  75                  80


Val Val Asp Gly Ile Asp Cys Leu Leu Ala Gln Lys Val Arg Pro Arg 
                85                  90                  95


Arg Trp Lys Leu Gln Val Leu Glu Met Arg Asp Val Asp Glu Asn Phe 
            100                 105                 110


Trp Thr Ile Trp Ser Gly Ala Arg Pro Leu Ser Cys Ser Pro Glu Ala 
        115                 120                 125


Met Ser Lys Arg Gln Thr Val Glu Asp Cys Pro Arg Thr Gly Glu Lys 
    130                 135                 140


Gln Pro Leu Lys Val Phe Met Asp Val Cys Leu Lys Glu Lys Ser Val 
145                 150                 155                 160


Asp Glu Asp Leu Ser Phe Phe Ser Gly Trp Val Gln His Arg Arg Arg 
                165                 170                 175


Ser Val His Leu Cys Cys Thr Lys Val Val Asn Tyr Ser Met Asn Ile 
            180                 185                 190


Leu Asn Phe Arg Asn Ile Leu Glu Thr Val Tyr Pro Asp Ser Ile Gln 
        195                 200                 205


Val Leu Glu Ile Trp Asn Met Cys Trp Pro Cys Met Val Ala Glu Val 
    210                 215                 220


Ser Arg Tyr Leu Ser Gln Met Lys Asn Leu Arg Lys Leu Phe Ile Ser 
225                 230                 235                 240


Asp Gly Cys Gly Tyr Leu Pro Ser Phe Glu Ser Gln Gly Gln Leu Val 
                245                 250                 255


Ala Glu Phe Ser Ser Val Phe Leu Arg Leu Glu Tyr Leu Gln Met Leu 
            260                 265                 270


Tyr Met Arg Arg Ile Arg Phe Phe Glu Gly Tyr Leu Asp Gln Leu Ile 
        275                 280                 285


Arg Cys Leu Lys Ser Pro Leu Glu Thr Leu Ala Leu Thr Tyr Gly Ser 
    290                 295                 300


Leu Asp Glu Glu Asp Leu Lys Cys Leu Pro Trp Tyr Pro Ser Leu Ser 
305                 310                 315                 320


Gln Leu Lys Gln Leu Asn Leu Ser His Gly Thr Leu Arg Phe Ile Arg 
                325                 330                 335


Leu Glu Pro Leu Arg Ala Leu Leu Glu Lys Val Ala Ala Thr Leu Gln 
            340                 345                 350


Thr Leu Phe Leu Val Asp Cys Gly Ile Gly Asp Ser Lys Leu Arg Val 
        355                 360                 365


Ile Leu Pro Ala Leu Ser Arg Cys Ser Asn Leu Thr Thr Phe Cys Phe 
    370                 375                 380


His Gly Asn Asp Thr Ser Met Asp Gly Leu Lys Asp Leu Leu Arg His 
385                 390                 395                 400


Thr Gly Arg Leu Ser Asn Leu Ser Leu Glu Thr Tyr Pro Ala Pro Arg 
                405                 410                 415


Glu Ser Leu Asp Asn Arg Gly Arg Val Ile Ser Glu Leu Leu Thr Pro 
            420                 425                 430


Leu Gln Ala Glu Leu Met Arg Ile Leu Arg Glu Val Arg Glu Pro Asn 
        435                 440                 445


Arg Ile Phe Phe Gly Pro Val Ser Cys Pro Cys Cys Gly Met Ser Pro 
    450                 455                 460


Thr Glu Gln Leu Glu Phe Asn Phe Cys Leu Arg Gly Arg Pro Ala 
465                 470                 475


<210>  1519
<211>  1425
<212>  DNA
<213>  Homo sapiens

<400>  1519
atgagcctcc agtccccatc cagactcctg gagctggcag gccagagcct gctgaggaac     60

cagttcttga ccatcttcat cctggacgag ctgcccaggg aggtcttccc tctgatgttc    120

atggaggcct ccagcatgag acattttgag gccctgaagc tgatggtgca ggcctggccc    180

ttcctccgcc tccctctggg atccctgatg aagacacctc atctggagac cttgcaagct    240

gtgctgaagg gacttgatac actgctggcc cagaagcttc gccccaggag gtggaaactt    300

caagtgctgg atttgcggga tgttgatggg aatttctgga ctatatggtc tggagccagg    360

gccctctcct gctccccaga ggccatgaga aagaggcaga cagtggagga ctatccaagg    420

acgggagagc accagccctt gaaggtgttc atagacctct gccaaaagga aagtacactg    480

gatgaatgcc tgagctacct ctgcaggtgg atccactaca gaagaggtct agtgcacctg    540

tgttgtaata aggtgcagaa ttactcaatg cccacttcaa gtttcagaaa tttattgaaa    600

agggtatacc cagacagtat ccaggagttg gaaattaaga gaaagtgctc tctgaataaa    660

acaggaaagt ttgcccctta cttgagccag atgagcaatc ttcgcaaact ctttttagcc    720

ttcggttatg acgatgagtt atatgtaagc ggccaacagc agttcgttcc tgacttggac    780

tgtccattcc tctgcctgta ctaccctcag atgctttata taagaaagat cagtaatatc    840

aaagagcacc tggagcacct gctcaggtgc ctcaagaacc ccttgggaac ctttatattc    900

tgtcatgctt acctagctga tcaggacatg gagtgtctgt ctcagtaccc aagcctcagt    960

cagctaaagg agctgcatct gattcatatc ctaatgtgga ctaccaatct tgagcccctt   1020

ggagctctgc tagagaaagt tgctgctact ctcgagatcc tcacgttaaa ggactgtcag   1080

atccaggact cccagctcag ggtcctcctg cctgccctga gccgctgctc ccagctcacc   1140

accttctact ttcgcggaaa tgagacctcc acgaatgctc tgaaagacct gctgtgtcac   1200

acaggtgggc tgagcaagtt aggtctggag ttgtatcctg cccctctgga gtgtcttgac   1260

aacaggggtc atgtcaattg ggagatcctc gccccaattc gggctgagct gatgtgtaca   1320

ctcagggaag tcaggcagcc caagaggatc ttttttggtc ccatcccctg cccttcctgt   1380

ggctcatggc catctgagaa agtggacttc catctttgct cttag                   1425


<210>  1520
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  1520

Met Ser Leu Gln Ser Pro Ser Arg Leu Leu Glu Leu Ala Gly Gln Ser 
1               5                   10                  15


Leu Leu Arg Asn Gln Phe Leu Thr Ile Phe Ile Leu Asp Glu Leu Pro 
            20                  25                  30


Arg Glu Val Phe Pro Leu Met Phe Met Glu Ala Ser Ser Met Arg His 
        35                  40                  45


Phe Glu Ala Leu Lys Leu Met Val Gln Ala Trp Pro Phe Leu Arg Leu 
    50                  55                  60


Pro Leu Gly Ser Leu Met Lys Thr Pro His Leu Glu Thr Leu Gln Ala 
65                  70                  75                  80


Val Leu Lys Gly Leu Asp Thr Leu Leu Ala Gln Lys Leu Arg Pro Arg 
                85                  90                  95


Arg Trp Lys Leu Gln Val Leu Asp Leu Arg Asp Val Asp Gly Asn Phe 
            100                 105                 110


Trp Thr Ile Trp Ser Gly Ala Arg Ala Leu Ser Cys Ser Pro Glu Ala 
        115                 120                 125


Met Arg Lys Arg Gln Thr Val Glu Asp Tyr Pro Arg Thr Gly Glu His 
    130                 135                 140


Gln Pro Leu Lys Val Phe Ile Asp Leu Cys Gln Lys Glu Ser Thr Leu 
145                 150                 155                 160


Asp Glu Cys Leu Ser Tyr Leu Cys Arg Trp Ile His Tyr Arg Arg Gly 
                165                 170                 175


Leu Val His Leu Cys Cys Asn Lys Val Gln Asn Tyr Ser Met Pro Thr 
            180                 185                 190


Ser Ser Phe Arg Asn Leu Leu Lys Arg Val Tyr Pro Asp Ser Ile Gln 
        195                 200                 205


Glu Leu Glu Ile Lys Arg Lys Cys Ser Leu Asn Lys Thr Gly Lys Phe 
    210                 215                 220


Ala Pro Tyr Leu Ser Gln Met Ser Asn Leu Arg Lys Leu Phe Leu Ala 
225                 230                 235                 240


Phe Gly Tyr Asp Asp Glu Leu Tyr Val Ser Gly Gln Gln Gln Phe Val 
                245                 250                 255


Pro Asp Leu Asp Cys Pro Phe Leu Cys Leu Tyr Tyr Pro Gln Met Leu 
            260                 265                 270


Tyr Ile Arg Lys Ile Ser Asn Ile Lys Glu His Leu Glu His Leu Leu 
        275                 280                 285


Arg Cys Leu Lys Asn Pro Leu Gly Thr Phe Ile Phe Cys His Ala Tyr 
    290                 295                 300


Leu Ala Asp Gln Asp Met Glu Cys Leu Ser Gln Tyr Pro Ser Leu Ser 
305                 310                 315                 320


Gln Leu Lys Glu Leu His Leu Ile His Ile Leu Met Trp Thr Thr Asn 
                325                 330                 335


Leu Glu Pro Leu Gly Ala Leu Leu Glu Lys Val Ala Ala Thr Leu Glu 
            340                 345                 350


Ile Leu Thr Leu Lys Asp Cys Gln Ile Gln Asp Ser Gln Leu Arg Val 
        355                 360                 365


Leu Leu Pro Ala Leu Ser Arg Cys Ser Gln Leu Thr Thr Phe Tyr Phe 
    370                 375                 380


Arg Gly Asn Glu Thr Ser Thr Asn Ala Leu Lys Asp Leu Leu Cys His 
385                 390                 395                 400


Thr Gly Gly Leu Ser Lys Leu Gly Leu Glu Leu Tyr Pro Ala Pro Leu 
                405                 410                 415


Glu Cys Leu Asp Asn Arg Gly His Val Asn Trp Glu Ile Leu Ala Pro 
            420                 425                 430


Ile Arg Ala Glu Leu Met Cys Thr Leu Arg Glu Val Arg Gln Pro Lys 
        435                 440                 445


Arg Ile Phe Phe Gly Pro Ile Pro Cys Pro Ser Cys Gly Ser Trp Pro 
    450                 455                 460


Ser Glu Lys Val Asp Phe His Leu Cys Ser 
465                 470


<210>  1521
<211>  1832
<212>  DNA
<213>  Homo sapiens

<400>  1521
ctgcttgatt ctctgagaga tcccagcacc ctacaaactg agtccagatc tgagttttcc     60

cttgcagatt catcaagatg agcatcaggg ccccacccag actcctggag ctggcaaggc    120

agaggctgct gagggaccag gccttggcca tctccaccat ggaggagctg cccagggagc    180

tcttccccac actgttcatg gaggccttca gcaggagacg ctgtgaaacc ctgaaaacaa    240

tggtgcaggc ctggcctttc acccgcctcc ctctagggtc cctgatgaag tcgcctcatc    300

tggagtcatt aaaatctgtg ctggaagggg ttgatgtgct gttgacccaa gaggttcgcc    360

ccaggcagtc aaaacttcaa gtgctggact tgaggaatgt ggatgagaac ttctgcgaca    420

tattttctgg agctactgca tccttcccgg aggctctgag tcagaagcaa acagcagata    480

actgtccagg gacaggcagg cagcagccat tcatggtgtt catagacctt tgtctcaaga    540

acaggacact agatgaatgc ctcacccacc tcttagagtg gggcaagcag agaaaaggct    600

tactgcatgt gtgttgcaag gagctgcagg tttttggaat gcccatccac agtatcatag    660

aggtcctgaa catggtggag cttgactgta tccaggaggt ggaagtgtgc tgcccctggg    720

agctgtccac tcttgtgaag tttgcccctt acctgggcca gatgaggaat ctccgcaaac    780

ttgttctctt caacatccgt gcatctgcct gcattccccc agacaacaag gggcagttca    840

ttgcccgatt cacctctcag ttcctcaagc tggactattt ccagaatctg tctatgcact    900

ccgtctcttt cctcgaaggc cacctggacc agctgctcag gtgtctccag gcctccttgg    960

agatggtcgt tatgaccgac tgcctgctgt cagagtcgga cttgaagcat ctctcttggt   1020

gcccgagcat ccgtcaatta aaggagctgg acctgagggg tgtcacactg acccatttca   1080

gccctgagcc cctcacaggt ctgctggagc aagttgtggc caccctgcag accctggact   1140

tagaggactg tgggatcatg gattcccaac tcagcgccat cctgcctgtc ctgagccgct   1200

gctcccagct cagcaccttc agcttctgtg ggaacctcat ctccatggct gcccttgaga   1260

acctgctgcg ccacaccgtc gggctgagca agctaagcct ggagctgtat cctgcccctc   1320

tggagagtta tgacacccag ggtgctctct gctgggggag atttgctgaa cttggggctg   1380

agctgatgaa gacactgagg gacttaaggc agcccaagat cattgtgttc tgcaccgtcc   1440

cctgccctcg ctgtggcatc agggcctcct atgacctgga gcccagtcac tgcctctgtt   1500

gaatgcctgc catcagggtg gatatatttc aagctttctt ctggtcattt cggagctgaa   1560

acctaggcca tgagtgcatg ttaaagggag cacagaccca tcgtttcaaa tgcctcctca   1620

gtgtgaatgg gaaaggaatg aggatgcagg aggggcagga ctgggggaaa agttgacttg   1680

gagtggatgg gctctttaga gacctgtgtc ccagagaatc agaaatggga atctgaattg   1740

ctagagtgag aatcagggag gagagacaca tgagagggtt acccctgcac agatggttgt   1800

aaagtaacag tcagaaataa agggaaactg ag                                 1832


<210>  1522
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  1522

Met Ser Ile Arg Ala Pro Pro Arg Leu Leu Glu Leu Ala Arg Gln Arg 
1               5                   10                  15


Leu Leu Arg Asp Gln Ala Leu Ala Ile Ser Thr Met Glu Glu Leu Pro 
            20                  25                  30


Arg Glu Leu Phe Pro Thr Leu Phe Met Glu Ala Phe Ser Arg Arg Arg 
        35                  40                  45


Cys Glu Thr Leu Lys Thr Met Val Gln Ala Trp Pro Phe Thr Arg Leu 
    50                  55                  60


Pro Leu Gly Ser Leu Met Lys Ser Pro His Leu Glu Ser Leu Lys Ser 
65                  70                  75                  80


Val Leu Glu Gly Val Asp Val Leu Leu Thr Gln Glu Val Arg Pro Arg 
                85                  90                  95


Gln Ser Lys Leu Gln Val Leu Asp Leu Arg Asn Val Asp Glu Asn Phe 
            100                 105                 110


Cys Asp Ile Phe Ser Gly Ala Thr Ala Ser Phe Pro Glu Ala Leu Ser 
        115                 120                 125


Gln Lys Gln Thr Ala Asp Asn Cys Pro Gly Thr Gly Arg Gln Gln Pro 
    130                 135                 140


Phe Met Val Phe Ile Asp Leu Cys Leu Lys Asn Arg Thr Leu Asp Glu 
145                 150                 155                 160


Cys Leu Thr His Leu Leu Glu Trp Gly Lys Gln Arg Lys Gly Leu Leu 
                165                 170                 175


His Val Cys Cys Lys Glu Leu Gln Val Phe Gly Met Pro Ile His Ser 
            180                 185                 190


Ile Ile Glu Val Leu Asn Met Val Glu Leu Asp Cys Ile Gln Glu Val 
        195                 200                 205


Glu Val Cys Cys Pro Trp Glu Leu Ser Thr Leu Val Lys Phe Ala Pro 
    210                 215                 220


Tyr Leu Gly Gln Met Arg Asn Leu Arg Lys Leu Val Leu Phe Asn Ile 
225                 230                 235                 240


Arg Ala Ser Ala Cys Ile Pro Pro Asp Asn Lys Gly Gln Phe Ile Ala 
                245                 250                 255


Arg Phe Thr Ser Gln Phe Leu Lys Leu Asp Tyr Phe Gln Asn Leu Ser 
            260                 265                 270


Met His Ser Val Ser Phe Leu Glu Gly His Leu Asp Gln Leu Leu Arg 
        275                 280                 285


Cys Leu Gln Ala Ser Leu Glu Met Val Val Met Thr Asp Cys Leu Leu 
    290                 295                 300


Ser Glu Ser Asp Leu Lys His Leu Ser Trp Cys Pro Ser Ile Arg Gln 
305                 310                 315                 320


Leu Lys Glu Leu Asp Leu Arg Gly Val Thr Leu Thr His Phe Ser Pro 
                325                 330                 335


Glu Pro Leu Thr Gly Leu Leu Glu Gln Val Val Ala Thr Leu Gln Thr 
            340                 345                 350


Leu Asp Leu Glu Asp Cys Gly Ile Met Asp Ser Gln Leu Ser Ala Ile 
        355                 360                 365


Leu Pro Val Leu Ser Arg Cys Ser Gln Leu Ser Thr Phe Ser Phe Cys 
    370                 375                 380


Gly Asn Leu Ile Ser Met Ala Ala Leu Glu Asn Leu Leu Arg His Thr 
385                 390                 395                 400


Val Gly Leu Ser Lys Leu Ser Leu Glu Leu Tyr Pro Ala Pro Leu Glu 
                405                 410                 415


Ser Tyr Asp Thr Gln Gly Ala Leu Cys Trp Gly Arg Phe Ala Glu Leu 
            420                 425                 430


Gly Ala Glu Leu Met Lys Thr Leu Arg Asp Leu Arg Gln Pro Lys Ile 
        435                 440                 445


Ile Val Phe Cys Thr Val Pro Cys Pro Arg Cys Gly Ile Arg Ala Ser 
    450                 455                 460


Tyr Asp Leu Glu Pro Ser His Cys Leu Cys 
465                 470


<210>  1523
<211>  291
<212>  DNA
<213>  Homo sapiens

<400>  1523
atgagcctcc aggccccatc cagactgctg gagctggcag ggcagagcct gctgaggaac     60

cagttcttga ccatcttcac cctggatgag ctgcccaggg aggtcttccc tctgatgttc    120

atggaggcct tcagcatgag acgttttgag gccctgaagc tgatggtgca ggcctggccc    180

ttcctccgcc tccctctggg atccctgatg aagacacctc atctggagac cttgcaagct    240

gtcctgaggg gacttgatac actggtggcc cagaaggttc gccccaggtg a             291


<210>  1524
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  1524

Met Ser Leu Gln Ala Pro Ser Arg Leu Leu Glu Leu Ala Gly Gln Ser 
1               5                   10                  15


Leu Leu Arg Asn Gln Phe Leu Thr Ile Phe Thr Leu Asp Glu Leu Pro 
            20                  25                  30


Arg Glu Val Phe Pro Leu Met Phe Met Glu Ala Phe Ser Met Arg Arg 
        35                  40                  45


Phe Glu Ala Leu Lys Leu Met Val Gln Ala Trp Pro Phe Leu Arg Leu 
    50                  55                  60


Pro Leu Gly Ser Leu Met Lys Thr Pro His Leu Glu Thr Leu Gln Ala 
65                  70                  75                  80


Val Leu Arg Gly Leu Asp Thr Leu Val Ala Gln Lys Val Arg Pro Arg 
                85                  90                  95


<210>  1525
<211>  1871
<212>  DNA
<213>  Homo sapiens

<400>  1525
caggagagac ccaaagtctt caagcctgga gttcctgctt ggttcttcct gaggtctgag     60

caccttctag actacatcca gatctgtttt ccctgcagat tcatgaagat gagcatccgg    120

actccaccca gactcctgga gcttgcaggg cggagcctgc tgagggacca agctttggcc    180

atgtccaccc tggaggagct gcccacagaa cttttccccc cactgttcat ggaggccttc    240

agcaggagac gctgtgaggc cctgaagctg atggtgcagg cctggccctt ccgccgcctc    300

cctctgaggc ctctgataaa gatgccttgt ctggaggcct tccaagctgt gctcgatggg    360

cttgatgcac tgcttaccca aggggttcgt cccaggaggt ggaaactcca agtgctggat    420

ttacaggatg tctgtgagaa cttctggatg gtttggtctg aagctatggc ccatgggtgc    480

ttcctcaatg ccaagaggaa caaaaaacca gtgcaggact gtccaaggat gagaggacgg    540

cagcccttga ctgtgttcgt agaactttgg ctcaagaaca ggactctgga tgaatacctc    600

acctacctcc ttctatgggt caagcagagg aaagatttac tacacctgtg ctgtaagaag    660

ctgaaaattt tgggaatgcc cttccgcaat atcagaagca tcctgaaaat ggtgaaccta    720

gactgtatcc aggaggtgga agtgaattgc aagtgggtac tgcccatcct gacacagttt    780

accccatacc tgggccacat gaggaatctt cagaagctcg ttctctccca catggatgtc    840

tctcgctacg tttccccaga gcagaagaag gagattgtta cccagttcac cactcagttc    900

ctcaagctgc gctgcctcca aaagctttat atgaactctg tttctttcct cgaaggccac    960

ctggaccagc tgctcagctg tctgaagacc tcgttaaaag tcctcacaat aactaactgt   1020

gtgcttttgg aatcagactt gaagcatcta tcccagtgcc cgagtatcag tcaactaaag   1080

accctggacc tgagtggcat cagactgacc aattatagtc ttgtgcctct ccaaattctc   1140

ctagaaaaag ttgcagccac ccttgagtac ctggatttag atgactgtgg catcatagac   1200

tcccaagtca acgccatcct gcctgccctg agccgctgct ttgagctcaa caccttcagc   1260

ttctgtggaa atcccatctg catggccacc ctggagaacc tgctgagcca cacaatcata   1320

ctcaaaaact tatgtgtgga gctgtatcct gccccccgag agagttatgg tgctgatggt   1380

actctctgct ggagcagatt tgctcaaatt agggctgagc tgatgaacag agtgagggac   1440

ttaaggcacc ccaagaggat cttgttctgt actgactact gccctgactg tggcaacagg   1500

tcattttatg acctggaggc agatcaatac tgctgttgaa tgcctgccta tttggatggg   1560

tatgtcaaac gctttcttct ggacacttgg aaactaaaac ctaggtctta ggtacatcct   1620

aaagggagca cagaacccat catttcacac ataggctctg aaagtgggaa aggaaagctg   1680

atcaagcagg ggccggactt gggggaaatg ttgccatgga ttcgatggga ctttggggac   1740

ctgtgtcctg tagattcgaa aatgggaatc tgaatgtcta gagtggaatt caggcttgag   1800

aatacatgag ggagttactc ttgcatggat ggttgtaaag aaacaatcag aaataaagga   1860

aaactgagca g                                                        1871


<210>  1526
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  1526

Met Lys Met Ser Ile Arg Thr Pro Pro Arg Leu Leu Glu Leu Ala Gly 
1               5                   10                  15


Arg Ser Leu Leu Arg Asp Gln Ala Leu Ala Met Ser Thr Leu Glu Glu 
            20                  25                  30


Leu Pro Thr Glu Leu Phe Pro Pro Leu Phe Met Glu Ala Phe Ser Arg 
        35                  40                  45


Arg Arg Cys Glu Ala Leu Lys Leu Met Val Gln Ala Trp Pro Phe Arg 
    50                  55                  60


Arg Leu Pro Leu Arg Pro Leu Ile Lys Met Pro Cys Leu Glu Ala Phe 
65                  70                  75                  80


Gln Ala Val Leu Asp Gly Leu Asp Ala Leu Leu Thr Gln Gly Val Arg 
                85                  90                  95


Pro Arg Arg Trp Lys Leu Gln Val Leu Asp Leu Gln Asp Val Cys Glu 
            100                 105                 110


Asn Phe Trp Met Val Trp Ser Glu Ala Met Ala His Gly Cys Phe Leu 
        115                 120                 125


Asn Ala Lys Arg Asn Lys Lys Pro Val Gln Asp Cys Pro Arg Met Arg 
    130                 135                 140


Gly Arg Gln Pro Leu Thr Val Phe Val Glu Leu Trp Leu Lys Asn Arg 
145                 150                 155                 160


Thr Leu Asp Glu Tyr Leu Thr Tyr Leu Leu Leu Trp Val Lys Gln Arg 
                165                 170                 175


Lys Asp Leu Leu His Leu Cys Cys Lys Lys Leu Lys Ile Leu Gly Met 
            180                 185                 190


Pro Phe Arg Asn Ile Arg Ser Ile Leu Lys Met Val Asn Leu Asp Cys 
        195                 200                 205


Ile Gln Glu Val Glu Val Asn Cys Lys Trp Val Leu Pro Ile Leu Thr 
    210                 215                 220


Gln Phe Thr Pro Tyr Leu Gly His Met Arg Asn Leu Gln Lys Leu Val 
225                 230                 235                 240


Leu Ser His Met Asp Val Ser Arg Tyr Val Ser Pro Glu Gln Lys Lys 
                245                 250                 255


Glu Ile Val Thr Gln Phe Thr Thr Gln Phe Leu Lys Leu Arg Cys Leu 
            260                 265                 270


Gln Lys Leu Tyr Met Asn Ser Val Ser Phe Leu Glu Gly His Leu Asp 
        275                 280                 285


Gln Leu Leu Ser Cys Leu Lys Thr Ser Leu Lys Val Leu Thr Ile Thr 
    290                 295                 300


Asn Cys Val Leu Leu Glu Ser Asp Leu Lys His Leu Ser Gln Cys Pro 
305                 310                 315                 320


Ser Ile Ser Gln Leu Lys Thr Leu Asp Leu Ser Gly Ile Arg Leu Thr 
                325                 330                 335


Asn Tyr Ser Leu Val Pro Leu Gln Ile Leu Leu Glu Lys Val Ala Ala 
            340                 345                 350


Thr Leu Glu Tyr Leu Asp Leu Asp Asp Cys Gly Ile Ile Asp Ser Gln 
        355                 360                 365


Val Asn Ala Ile Leu Pro Ala Leu Ser Arg Cys Phe Glu Leu Asn Thr 
    370                 375                 380


Phe Ser Phe Cys Gly Asn Pro Ile Cys Met Ala Thr Leu Glu Asn Leu 
385                 390                 395                 400


Leu Ser His Thr Ile Ile Leu Lys Asn Leu Cys Val Glu Leu Tyr Pro 
                405                 410                 415


Ala Pro Arg Glu Ser Tyr Gly Ala Asp Gly Thr Leu Cys Trp Ser Arg 
            420                 425                 430


Phe Ala Gln Ile Arg Ala Glu Leu Met Asn Arg Val Arg Asp Leu Arg 
        435                 440                 445


His Pro Lys Arg Ile Leu Phe Cys Thr Asp Tyr Cys Pro Asp Cys Gly 
    450                 455                 460


Asn Arg Ser Phe Tyr Asp Leu Glu Ala Asp Gln Tyr Cys Cys 
465                 470                 475


<210>  1527
<211>  1425
<212>  DNA
<213>  Homo sapiens

<400>  1527
atgagcctcc agtccccatc cagactcctg gagctggcag gccagagcct gctgaggaac     60

cagttcttga ccatcttcat cctggacgag ctgcccaggg aggtcttccc tctgatgttc    120

atggaggcct ccagcatgag acattttgag gccctgaagc tgatggtgca ggcctggccc    180

ttcctccgcc tccctctggg atccctgatg aagacacctc atctggagac cttgcaagct    240

gtgctgaagg gacttgatac actgctggcc cagaagcttc gccccaggag gtggaaactt    300

caagtgctgg atttgcggga tgttgatggg aatttctgga ctatatggtc tggagccagg    360

gccctctcct gctccccaga ggccatgagt aagaggcaga cagtggagga ctatccaagg    420

acgggagagc accagccctt gaaggtgttc atagacctct gccaaaagga aagtacactg    480

gatgaatgcc tgagctacct ctgcaggtgg atccactaca gaagaggtct agtgcacctg    540

tgttgtaata aggtgcagaa ttactcaatg cccacttcaa gtttcagaaa tttattgaaa    600

agggtatacc cagacagtat ccaggagttg gaaattaaga gaaagtgctc tctgaataaa    660

acaggaaagt ttgcccctta cttgagccag atgagcaatc ttcgcaaact ctttttagcc    720

ttcggttatg acgatgagtt atatgtaagc ggccaacagc agttcgttcc tgacttggac    780

tgtccattcc tctgcctgta ctaccctcag atgctttata taagaaagat cagtaatatc    840

aaagagcacc tggagcacct gctcaggtgc ctcaagaacc ccttgggaac ctttatattc    900

tgtcatgctt acctagctga tcaggacatg gagtgtctgt ctcagtaccc aagcctcagt    960

cagctaaagg agctgcatct gattcatatc ctaatgtgga ccaccaatct tgagcccctt   1020

ggagctctgc tagagaaagt tgctgctact ctcgagatcc tcacgttaaa ggactgtcag   1080

atccaggact cccagctcag ggtcctcctg cctgccctga gccgctgctc ccagctcacc   1140

accttctact ttcgcggaaa tgagacctcc acgaatgctc tgaaagacct gctgtgtcac   1200

acaggtgggc tgagcaagtt aggtctggag ttgtatcctg cccctctgga gtgtcttgac   1260

aacaggggtc atgtcaattg ggagatcctc gccccaattc gggctgagct gatgtgtaca   1320

ctcagggaag tcaggcagcc caagaggatc ttttttggtc ccatcccctg cccttcctgt   1380

ggctcatggc catctgagaa agtggacttc catctttgct cttag                   1425


<210>  1528
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  1528

Met Ser Leu Gln Ser Pro Ser Arg Leu Leu Glu Leu Ala Gly Gln Ser 
1               5                   10                  15


Leu Leu Arg Asn Gln Phe Leu Thr Ile Phe Ile Leu Asp Glu Leu Pro 
            20                  25                  30


Arg Glu Val Phe Pro Leu Met Phe Met Glu Ala Ser Ser Met Arg His 
        35                  40                  45


Phe Glu Ala Leu Lys Leu Met Val Gln Ala Trp Pro Phe Leu Arg Leu 
    50                  55                  60


Pro Leu Gly Ser Leu Met Lys Thr Pro His Leu Glu Thr Leu Gln Ala 
65                  70                  75                  80


Val Leu Lys Gly Leu Asp Thr Leu Leu Ala Gln Lys Leu Arg Pro Arg 
                85                  90                  95


Arg Trp Lys Leu Gln Val Leu Asp Leu Arg Asp Val Asp Gly Asn Phe 
            100                 105                 110


Trp Thr Ile Trp Ser Gly Ala Arg Ala Leu Ser Cys Ser Pro Glu Ala 
        115                 120                 125


Met Ser Lys Arg Gln Thr Val Glu Asp Tyr Pro Arg Thr Gly Glu His 
    130                 135                 140


Gln Pro Leu Lys Val Phe Ile Asp Leu Cys Gln Lys Glu Ser Thr Leu 
145                 150                 155                 160


Asp Glu Cys Leu Ser Tyr Leu Cys Arg Trp Ile His Tyr Arg Arg Gly 
                165                 170                 175


Leu Val His Leu Cys Cys Asn Lys Val Gln Asn Tyr Ser Met Pro Thr 
            180                 185                 190


Ser Ser Phe Arg Asn Leu Leu Lys Arg Val Tyr Pro Asp Ser Ile Gln 
        195                 200                 205


Glu Leu Glu Ile Lys Arg Lys Cys Ser Leu Asn Lys Thr Gly Lys Phe 
    210                 215                 220


Ala Pro Tyr Leu Ser Gln Met Ser Asn Leu Arg Lys Leu Phe Leu Ala 
225                 230                 235                 240


Phe Gly Tyr Asp Asp Glu Leu Tyr Val Ser Gly Gln Gln Gln Phe Val 
                245                 250                 255


Pro Asp Leu Asp Cys Pro Phe Leu Cys Leu Tyr Tyr Pro Gln Met Leu 
            260                 265                 270


Tyr Ile Arg Lys Ile Ser Asn Ile Lys Glu His Leu Glu His Leu Leu 
        275                 280                 285


Arg Cys Leu Lys Asn Pro Leu Gly Thr Phe Ile Phe Cys His Ala Tyr 
    290                 295                 300


Leu Ala Asp Gln Asp Met Glu Cys Leu Ser Gln Tyr Pro Ser Leu Ser 
305                 310                 315                 320


Gln Leu Lys Glu Leu His Leu Ile His Ile Leu Met Trp Thr Thr Asn 
                325                 330                 335


Leu Glu Pro Leu Gly Ala Leu Leu Glu Lys Val Ala Ala Thr Leu Glu 
            340                 345                 350


Ile Leu Thr Leu Lys Asp Cys Gln Ile Gln Asp Ser Gln Leu Arg Val 
        355                 360                 365


Leu Leu Pro Ala Leu Ser Arg Cys Ser Gln Leu Thr Thr Phe Tyr Phe 
    370                 375                 380


Arg Gly Asn Glu Thr Ser Thr Asn Ala Leu Lys Asp Leu Leu Cys His 
385                 390                 395                 400


Thr Gly Gly Leu Ser Lys Leu Gly Leu Glu Leu Tyr Pro Ala Pro Leu 
                405                 410                 415


Glu Cys Leu Asp Asn Arg Gly His Val Asn Trp Glu Ile Leu Ala Pro 
            420                 425                 430


Ile Arg Ala Glu Leu Met Cys Thr Leu Arg Glu Val Arg Gln Pro Lys 
        435                 440                 445


Arg Ile Phe Phe Gly Pro Ile Pro Cys Pro Ser Cys Gly Ser Trp Pro 
    450                 455                 460


Ser Glu Lys Val Asp Phe His Leu Cys Ser 
465                 470


<210>  1529
<211>  1506
<212>  DNA
<213>  Homo sapiens

<400>  1529
atgcttatgc tgatgcagca gaggcagaag cctggctttg tggccactga gtacagagta     60

gaattggaat tcaggaagat gagcatccgg actccaccca gactcctgga gctggcgggg    120

cggagcctgc tgagggacga ggccttggcc atctccaccc tggaggagct gcccacggaa    180

ctttttcccc cattgttcat ggaggccttc agcaggagac actgtgaggc cctgaagctg    240

atggtgcagg cctggccttt cctccgcctt cctctggggt ctctgatgaa aaggccttgc    300

ccagagacct tccaagctgt gctcgatggg cttgatgcac tgcttaccca cagggttcgt    360

ctcaggaggt ggaaacttca agtgctggat ttacaggatg tcagtgagaa cttctggatg    420

gtttggtctg aagccatggc ccgtaggtgc ttaccaaatg ccatgatgaa cagaaaacca    480

gtgcaggact gtccaaggat gagaggacag cagcccttga ctgtgttcat agacctttgc    540

ctcaagaaca ggactctgga tgaatacttc acctgcctct ttctatgggt caagcagagg    600

gaaggtttag tacacctgtg ctgtaagaag ctgaaaatgt tgggaatgct cttccacaat    660

atcagaaaca tcctgaaaac agtcaaccta gactgtatcc aggaggtgga agtgaattgc    720

aattggacac tgcccgtcct ggcagagttt accccatacc tcggccagat gaggaatctt    780

cggaagctcg ttctctctga catagattct cgctacattt ccccagagca gaagaaggag    840

tttgttaccc agttcaccac tcagttcctc aagctgcgct gcctccaaaa gctttatatg    900

aactctgttt ctttcctcga aggccacctg gaccagatgc tcagctgtct aaagacctcg    960

ttaaacatcc tcgcaataac taactgtgtg cttttggaat cagacttgaa gcatctgtcc   1020

aagtacccga gcattggtca actaaagacc ctggacctga gtggcaccag actggccaat   1080

ttcagccttg tgccgctcca agttctccta gaaaaagttg cagccaccct tgagtacctg   1140

gacttagatg actgtggcat cgtagactcc caagtcaacg ccatcctgcc tgccctgagc   1200

cgctgctttg agctcaccac cttcagcttc cgtggaaatc ccatctccac ggccaccctg   1260

gagaacctgc tgtgccacac aatcagactc aacaacttat gcctggagct gtatcctgcc   1320

ccgcgggaga gttatgatgt tcgtggtatc gtctgccgga gcagatttgc ccaacttggg   1380

gctgagctga tggggagagt gagggcctta agggagcccg agaggatctt gttctgtacc   1440

gactactgcc ctcagtgtgg caacaggtca ctttacgacc tggaggtaga tcggtgttgc   1500

tgttga                                                              1506


<210>  1530
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  1530

Met Leu Met Leu Met Gln Gln Arg Gln Lys Pro Gly Phe Val Ala Thr 
1               5                   10                  15


Glu Tyr Arg Val Glu Leu Glu Phe Arg Lys Met Ser Ile Arg Thr Pro 
            20                  25                  30


Pro Arg Leu Leu Glu Leu Ala Gly Arg Ser Leu Leu Arg Asp Glu Ala 
        35                  40                  45


Leu Ala Ile Ser Thr Leu Glu Glu Leu Pro Thr Glu Leu Phe Pro Pro 
    50                  55                  60


Leu Phe Met Glu Ala Phe Ser Arg Arg His Cys Glu Ala Leu Lys Leu 
65                  70                  75                  80


Met Val Gln Ala Trp Pro Phe Leu Arg Leu Pro Leu Gly Ser Leu Met 
                85                  90                  95


Lys Arg Pro Cys Pro Glu Thr Phe Gln Ala Val Leu Asp Gly Leu Asp 
            100                 105                 110


Ala Leu Leu Thr His Arg Val Arg Leu Arg Arg Trp Lys Leu Gln Val 
        115                 120                 125


Leu Asp Leu Gln Asp Val Ser Glu Asn Phe Trp Met Val Trp Ser Glu 
    130                 135                 140


Ala Met Ala Arg Arg Cys Leu Pro Asn Ala Met Met Asn Arg Lys Pro 
145                 150                 155                 160


Val Gln Asp Cys Pro Arg Met Arg Gly Gln Gln Pro Leu Thr Val Phe 
                165                 170                 175


Ile Asp Leu Cys Leu Lys Asn Arg Thr Leu Asp Glu Tyr Phe Thr Cys 
            180                 185                 190


Leu Phe Leu Trp Val Lys Gln Arg Glu Gly Leu Val His Leu Cys Cys 
        195                 200                 205


Lys Lys Leu Lys Met Leu Gly Met Leu Phe His Asn Ile Arg Asn Ile 
    210                 215                 220


Leu Lys Thr Val Asn Leu Asp Cys Ile Gln Glu Val Glu Val Asn Cys 
225                 230                 235                 240


Asn Trp Thr Leu Pro Val Leu Ala Glu Phe Thr Pro Tyr Leu Gly Gln 
                245                 250                 255


Met Arg Asn Leu Arg Lys Leu Val Leu Ser Asp Ile Asp Ser Arg Tyr 
            260                 265                 270


Ile Ser Pro Glu Gln Lys Lys Glu Phe Val Thr Gln Phe Thr Thr Gln 
        275                 280                 285


Phe Leu Lys Leu Arg Cys Leu Gln Lys Leu Tyr Met Asn Ser Val Ser 
    290                 295                 300


Phe Leu Glu Gly His Leu Asp Gln Met Leu Ser Cys Leu Lys Thr Ser 
305                 310                 315                 320


Leu Asn Ile Leu Ala Ile Thr Asn Cys Val Leu Leu Glu Ser Asp Leu 
                325                 330                 335


Lys His Leu Ser Lys Tyr Pro Ser Ile Gly Gln Leu Lys Thr Leu Asp 
            340                 345                 350


Leu Ser Gly Thr Arg Leu Ala Asn Phe Ser Leu Val Pro Leu Gln Val 
        355                 360                 365


Leu Leu Glu Lys Val Ala Ala Thr Leu Glu Tyr Leu Asp Leu Asp Asp 
    370                 375                 380


Cys Gly Ile Val Asp Ser Gln Val Asn Ala Ile Leu Pro Ala Leu Ser 
385                 390                 395                 400


Arg Cys Phe Glu Leu Thr Thr Phe Ser Phe Arg Gly Asn Pro Ile Ser 
                405                 410                 415


Thr Ala Thr Leu Glu Asn Leu Leu Cys His Thr Ile Arg Leu Asn Asn 
            420                 425                 430


Leu Cys Leu Glu Leu Tyr Pro Ala Pro Arg Glu Ser Tyr Asp Val Arg 
        435                 440                 445


Gly Ile Val Cys Arg Ser Arg Phe Ala Gln Leu Gly Ala Glu Leu Met 
    450                 455                 460


Gly Arg Val Arg Ala Leu Arg Glu Pro Glu Arg Ile Leu Phe Cys Thr 
465                 470                 475                 480


Asp Tyr Cys Pro Gln Cys Gly Asn Arg Ser Leu Tyr Asp Leu Glu Val 
                485                 490                 495


Asp Arg Cys Cys Cys 
            500


<210>  1531
<211>  2353
<212>  DNA
<213>  Homo sapiens

<400>  1531
atggagctgc tgttgcagcc agttaacggg ctggtgacaa agtcgcaatt gtgtctgtgg     60

agcagggagc ctgttccatc gaggcaggct gccccaagta aaaggctaga gagtgtctcc    120

tttcctgggg cccatgagat gtcctcacgc tccctggcca ggccagtcag tccgtccgcg    180

ccgcgctcca tcgcccccgc acgcccgggc gcacgccctc cccgcccggg ccgccctctg    240

gctccccgcg cccggcagcc agtgcctcac cgcgccgtcc cgcgccaggg ctcgctccga    300

gagccgcttc cttctcgccg cggccggcgc gggccccccg gccatgcgcc cccgagcccc    360

agcctgcgcc gccgcggcgc tcgggctctg cagccttctg ctgctgctcg cgcccgggca    420

cgcgtgcccc gcgggctgcg cctgcaccga cccgcacacc gtggactgcc gcgaccgcgg    480

gctgcccagc gtgccagacc ctttccccct ggacgtgcgc aagctgctgg tggccggcaa    540

ccgcatccag cggatccccg aggacttctt catcttctac ggcgacctgg tctacctgga    600

cttcaggaac aactcgctgc gctcgctgga ggagggcacg ttcagcggct cggccaagct    660

cgtgttcctc gacctcagct acaacaactt gacccagctg ggcgccggcg ccttccgctc    720

ggccgggagg ctggtgaagc ttagcctggc taacaacaac ctggtgggcg tgcacgagga    780

cgccttcgag accctggagt cgctgcaggt gctggagctc aacgacaaca acctgcgcag    840

cctcagcgtg gccgccctgg ccgcgctgcc cgcgctgcgc tccctgcgtc tggacgggaa    900

cccctggctg tgcgactgtg acttcgccca cctcttctcc tggatccagg agaacgcatc    960

caaactgccc aaaggccttg atgaaatcca gtgctccctg cccatggaga gcaggaggat   1020

atccctgcgt gagctgtcgg aggccagctt cagcgagtgt aggttcagcc tgtcactcac   1080

agacctctgc atcatcattt tctccggtgt ggccgtgtcc attgcggcca tcatctccag   1140

cttcttcctg gccactgtgg tgcagtgcct ccagaggtgc gcacccaaca aagatgcgga   1200

ggatgaagac gaggacaagg atgactgagc cacctcctcc ctcctgcctc ttactctcca   1260

gcaccgaacc agaagctctc tccaagacga gagggaaatg ctgaaaatgg aaaagcactg   1320

gccaccatct gtgaactgaa cagagcctgt tccgtgtctt ggcccctggg tacacctgct   1380

gggaccactg atctcagagt ttagaatcag cagagcacag aagcccagga aggatggagg   1440

gaattattcc tggagcataa cctgcctctc agatcgaggt gtgtgttggg ggagaagatg   1500

accgagtcag gcttcatagc tgatgactaa aagcctcccc caggaaatgt gaagactggc   1560

agctttcaat ggcaaagatg attttacgcc attctttttc tgacctgtac tgggagatca   1620

tgaaacatct gccttcctcc caagaaacag cagctcaaac agtggagatt caaattcgga   1680

tcattcacca caagaacgag aactttgatc cttatataat aggcctcagc aaccttggga   1740

tgttatactg ggaactaata aactcgtgtg caatagactc aatgtttatg ttcccccaga   1800

ttttatatgt tgaaacctaa tccccaatgt gatggtattt ggaggtgggg cttttgggag   1860

gtgattaggt ttagatcata tcatgaggat ggggcccaaa tgatgggatt agtgccctca   1920

tgaaaggtgg ccccagagag ctccttcacc ccttcaatgc ttgaggatgc agcaagaaat   1980

cagctgccca tgaaccgaga agcaggccct caccagaacc cagccatgct ggcacccaga   2040

tctcagactt ccagcctcca gaactgggag aaataaataa atgtctgttg tttgtaagcc   2100

actcaatctc tggtattctg ttatagtggt cgaaatggac ccatgaagaa gctaacaact   2160

ggtcagaggg tgtctgttgt taattttggt aagctggttg ggaaaacttt gacttgacat   2220

aactcaaacc ctgatcttta tcctaagcgg tagcgacttg tagaggaagg attagttgct   2280

ttgtacagtt gtgatggtct ctctgctcag catcattttt ccttctgaag gacagacagg   2340

ttgttcccct cca                                                      2353


<210>  1532
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  1532

Met Arg Cys Pro His Ala Pro Trp Pro Gly Gln Ser Val Arg Pro Arg 
1               5                   10                  15


Arg Ala Pro Ser Pro Pro His Ala Arg Ala His Ala Leu Pro Ala Arg 
            20                  25                  30


Ala Ala Leu Trp Leu Pro Ala Pro Gly Ser Gln Cys Leu Thr Ala Pro 
        35                  40                  45


Ser Arg Ala Arg Ala Arg Ser Glu Ser Arg Phe Leu Leu Ala Ala Ala 
    50                  55                  60


Gly Ala Gly Pro Pro Ala Met Arg Pro Arg Ala Pro Ala Cys Ala Ala 
65                  70                  75                  80


Ala Ala Leu Gly Leu Cys Ser Leu Leu Leu Leu Leu Ala Pro Gly His 
                85                  90                  95


Ala Cys Pro Ala Gly Cys Ala Cys Thr Asp Pro His Thr Val Asp Cys 
            100                 105                 110


Arg Asp Arg Gly Leu Pro Ser Val Pro Asp Pro Phe Pro Leu Asp Val 
        115                 120                 125


Arg Lys Leu Leu Val Ala Gly Asn Arg Ile Gln Arg Ile Pro Glu Asp 
    130                 135                 140


Phe Phe Ile Phe Tyr Gly Asp Leu Val Tyr Leu Asp Phe Arg Asn Asn 
145                 150                 155                 160


Ser Leu Arg Ser Leu Glu Glu Gly Thr Phe Ser Gly Ser Ala Lys Leu 
                165                 170                 175


Val Phe Leu Asp Leu Ser Tyr Asn Asn Leu Thr Gln Leu Gly Ala Gly 
            180                 185                 190


Ala Phe Arg Ser Ala Gly Arg Leu Val Lys Leu Ser Leu Ala Asn Asn 
        195                 200                 205


Asn Leu Val Gly Val His Glu Asp Ala Phe Glu Thr Leu Glu Ser Leu 
    210                 215                 220


Gln Val Leu Glu Leu Asn Asp Asn Asn Leu Arg Ser Leu Ser Val Ala 
225                 230                 235                 240


Ala Leu Ala Ala Leu Pro Ala Leu Arg Ser Leu Arg Leu Asp Gly Asn 
                245                 250                 255


Pro Trp Leu Cys Asp Cys Asp Phe Ala His Leu Phe Ser Trp Ile Gln 
            260                 265                 270


Glu Asn Ala Ser Lys Leu Pro Lys Gly Leu Asp Glu Ile Gln Cys Ser 
        275                 280                 285


Leu Pro Met Glu Ser Arg Arg Ile Ser Leu Arg Glu Leu Ser Glu Ala 
    290                 295                 300


Ser Phe Ser Glu Cys Arg Phe Ser Leu Ser Leu Thr Asp Leu Cys Ile 
305                 310                 315                 320


Ile Ile Phe Ser Gly Val Ala Val Ser Ile Ala Ala Ile Ile Ser Ser 
                325                 330                 335


Phe Phe Leu Ala Thr Val Val Gln Cys Leu Gln Arg Cys Ala Pro Asn 
            340                 345                 350


Lys Asp Ala Glu Asp Glu Asp Glu Asp Lys Asp Asp 
        355                 360


<210>  1533
<211>  1911
<212>  DNA
<213>  Homo sapiens

<400>  1533
atcgcccccg cacgcccggg cgcacgccct ccccgcccgg gccgccctct ggctccccgc     60

gcccggcagc cagtgcctca ccgcgccgtc ccgcgccagg gctcgctccg agagccgctt    120

ccttctcgcc gcggccggcg cgggcccccc ggccatgcgc ccccgagccc cagcctgcgc    180

cgccgcggcg ctcgggctct gcagccttct gctgctgctc gcgcccgggc acgcgtgccc    240

cgcgggctgc gcctgcaccg acccgcacac cgtggactgc cgcgaccgcg ggctgcccag    300

cgtgccagac cctttccccc tggacgtgcg caagctgctg gtggccggca accgcatcca    360

gcggatcccc gaggacttct tcatcttcta cggcgacctg gtctacctgg acttcaggaa    420

caactcgctg cgctcgctgg aggagggcac gttcagcggc tcggccaagc tcgtgttcct    480

cgacctcagc tacaacaact tgacccagct gggcgccggc gccttccgct cggccgggag    540

gctggtgaag cttagcctgg ctaacaacaa cctggtgggc gtgcacgagg acgccttcga    600

gaccctggag tcgctgcagg tgctggagct caacgacaac aacctgcgca gcctcagcgt    660

ggccgccctg gccgcgctgc ccgcgctgcg ctccctgcgt ctggacggga acccctggct    720

gtgcgactgt gacttcgccc acctcttctc ctggatccag gagaacgcat ccaaactgcc    780

caaaggcctt gatgaaatcc agtgctccct gcccatggag agcaggagga tatccctgcg    840

tgagctgtcg gaggccagct tcagcgagtg taggttcagc ctgtcactca cagacctctg    900

catcatcatt ttctccggtg tggccgtgtc cattgcggcc atcatctcca gcttcttcct    960

ggccactgtg gtgcagtgcc tccagaggtg cgcacccaac aaagatgcgg aggatgaaga   1020

cgaggacaag gatgactgag ccacctcctc cctcctgcct cttactctcc agcaccgaac   1080

cagaagctct ctccaagacg agagggaaat gctgaaaatg gaaaagcact ggccaccatc   1140

tgtgaactga acagagcctg ttccgtgtct tggcccctgg gtacacctgc tgggaccact   1200

gatctcagag tttagaatca gcagagcaca gaagcccagg aaggatggag ggaattattc   1260

ctggagcata acctgcctct cagatcgagg tgtgtgttgg gggagaagat gaccgagtca   1320

ggcttcatag ctgatgacta aaagcctccc ccaggaaatg tgaagactgg cagctttcaa   1380

tggcaaagat gattttacgc cattcttttt ctgacctgta ctgggagatc atgaaacatc   1440

tgccttcctc ccaagaaaca gcagctcaaa cagtggagat tcaaattcgg atcattcacc   1500

acaagaacga gaactttgat ccttatataa taggcctcag caaccttggg atgttatact   1560

gggaactaat aaactcgtgt gcaatagact caatgtttat gttcccccag attttatatg   1620

ttgaaaccta atccccaatg tgatggtatt tggaggtggg gcttttggga ggtgattagg   1680

tttagatcat atcatgagga tggggcccaa atgatgggat tagtgccctc atgaaaggtg   1740

gccccagaga gctccttcac cccttcaatg cttgaggatg cagcaagaaa tcagctgccc   1800

atgaaccgag aagcaggccc tcaccagaac ccagccatgc tggcacccag atctcagact   1860

tccagcctcc agaactggga gaaataaata aatgtctgtt gtttgtaagc c            1911


<210>  1534
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  1534

Met Arg Pro Arg Ala Pro Ala Cys Ala Ala Ala Ala Leu Gly Leu Cys 
1               5                   10                  15


Ser Leu Leu Leu Leu Leu Ala Pro Gly His Ala Cys Pro Ala Gly Cys 
            20                  25                  30


Ala Cys Thr Asp Pro His Thr Val Asp Cys Arg Asp Arg Gly Leu Pro 
        35                  40                  45


Ser Val Pro Asp Pro Phe Pro Leu Asp Val Arg Lys Leu Leu Val Ala 
    50                  55                  60


Gly Asn Arg Ile Gln Arg Ile Pro Glu Asp Phe Phe Ile Phe Tyr Gly 
65                  70                  75                  80


Asp Leu Val Tyr Leu Asp Phe Arg Asn Asn Ser Leu Arg Ser Leu Glu 
                85                  90                  95


Glu Gly Thr Phe Ser Gly Ser Ala Lys Leu Val Phe Leu Asp Leu Ser 
            100                 105                 110


Tyr Asn Asn Leu Thr Gln Leu Gly Ala Gly Ala Phe Arg Ser Ala Gly 
        115                 120                 125


Arg Leu Val Lys Leu Ser Leu Ala Asn Asn Asn Leu Val Gly Val His 
    130                 135                 140


Glu Asp Ala Phe Glu Thr Leu Glu Ser Leu Gln Val Leu Glu Leu Asn 
145                 150                 155                 160


Asp Asn Asn Leu Arg Ser Leu Ser Val Ala Ala Leu Ala Ala Leu Pro 
                165                 170                 175


Ala Leu Arg Ser Leu Arg Leu Asp Gly Asn Pro Trp Leu Cys Asp Cys 
            180                 185                 190


Asp Phe Ala His Leu Phe Ser Trp Ile Gln Glu Asn Ala Ser Lys Leu 
        195                 200                 205


Pro Lys Gly Leu Asp Glu Ile Gln Cys Ser Leu Pro Met Glu Ser Arg 
    210                 215                 220


Arg Ile Ser Leu Arg Glu Leu Ser Glu Ala Ser Phe Ser Glu Cys Arg 
225                 230                 235                 240


Phe Ser Leu Ser Leu Thr Asp Leu Cys Ile Ile Ile Phe Ser Gly Val 
                245                 250                 255


Ala Val Ser Ile Ala Ala Ile Ile Ser Ser Phe Phe Leu Ala Thr Val 
            260                 265                 270


Val Gln Cys Leu Gln Arg Cys Ala Pro Asn Lys Asp Ala Glu Asp Glu 
        275                 280                 285


Asp Glu Asp Lys Asp Asp 
    290


<210>  1535
<211>  2595
<212>  DNA
<213>  Homo sapiens

<400>  1535
aatgtcagtg cccgcccctg cttacaggct ggggccatct gtaggcttgg acaggagggg     60

tttggggaga catggcctgc tgtctgggaa aatattgata acatgttccc aggatgaggc    120

atttctgacc cttgttgtgg tggaacgtgg tgttccttgt actttctccc agcagaatat    180

gataagaggc aggctatttc tcatggcctg aatccctgtg gaatatttca ctttaagcac    240

ggtctgtgaa atggcggggg acttacaaaa tggtgcagat tggactttct tgccttctac    300

tttaatataa aaggaagagg ggcgttgttg attatctggc tgtttcctgt cgaattaggg    360

gcactgtaac cagggtttgg gttttgaagt agtgggtgtt cgactttaga gttgttttcc    420

tggaagcgct gatactggac ttagtggagg agaacgacgg tatcaatgtg tttctggatg    480

actgcctgga caagggagtt cagcttttgg gagactgact gggctatgaa ggatggtaga    540

ggacagtctt cagcctgaga cccatcccta gttatatctt ctggacagat tcctagaagt    600

gggattactg gctcaaaagt gtacctttct actctgcaga ggctggaaag gcaaaaatga    660

tggctaaggc ttccttgcag tggccgtgcc attttgaatt tccactggca ttgaatgaga    720

gtccctgttc cacatccttg gcagcatttg tggtgttaac gttttggatt ttagccatcc    780

tcgtagccgc tgatacagaa gcctgaggga acacactccc ccctacgtcc ttctccaaca    840

cagcagagcc aggaaggacc cggatggaag ttaggacaaa gaggcccaga attggcacag    900

ataccaacag accattcgtt gaagaagaaa tccaaatggc cataagaacc ccagagatga    960

aaggcctcct cccactggct tggttcctgg cttgtagtgt gcctgctgtg caaggaggct   1020

tgctggacct aaaatcaatg atcgagaagg tgacagggaa gaacgccctg acaaactacg   1080

gcttctacgg ctgttactgc ggctggggcg gccgaggaac ccccaaggat ggcaccgatt   1140

ggtgctgttg ggcgcatgac cactgctatg ggcggctgga ggagaagggc tgcaacattc   1200

gcacacagtc ctacaaatac agattcgcgt ggggcgtggt cacctgcgag cccgggccct   1260

tctgccatgt gaacctctgt gcctgtgacc ggaagctcgt ctactgcctc aagagaaacc   1320

tacggagcta caacccacag taccaatact ttcccaacat cctctgctcc taggcctccc   1380

cagcgagctc ctcccagacc aagacttttg ttctgttttt ctacaacaca gagtactgac   1440

tctgcctggt tcctgagaga ggctcctaag tcacagacct cagtctttct cgaagcttgg   1500

cggaccccca gggccacact gtaccctcca gcgagtccca ggagagtgac tctggtcata   1560

ggacttggta gggtcccagg gtccctaggc ctccacttct gagggcagcc cctctggtgc   1620

caagagctct cctccaactc agggttggct gtgtctcttt tcttctctga agacagcgtc   1680

ctggctccag ttggaacact ttcctgagat gcacttactt ctcagcttct gcgatcagat   1740

tatcatcacc accaccctcc agagaatttt tacgcaagaa gagccaaatt gactctctaa   1800

atctggtgta tgggtattaa ataaaattca ttctcaaggc taataaaaac cacattggca   1860

ttttcctctg ctgtggggga tcgctggtgc ctctttctct gccactgggg caataaaccc   1920

aaagatgtct acattatctc cgaaacagaa gggaagatta gtaaatgcag ggttttctgg   1980

gatgagcttc aggctttctc ttgggctaat tttcttacac cttggggtcc tctccagtat   2040

tgggtctcat tcttcctcga tggggtcagg gaaagataac tggtgattat gccagcttca   2100

gcttccaggc cagagagggt ggcattcaaa tcccagtgct ggcttcttca gctgtgtggt   2160

cttggacccg ttactgaacc tctttgactt tcagtctctt tgagaaataa actgtcttgt   2220

tccttgcaat gtaaaatgag acttctaaag cccaccttga tgctgatatg gagaatgctg   2280

aggttctagg atttcacaca gcaggaattt ttttttaata ggtgtcagct gtggggttta   2340

ttttttacaa agtaaggaca ttaaaaaaac caacccgtct atcaattcat aaaagaaagg   2400

atgttctgat accaagactg aaagaagaaa ggatgtattc caaaacaaag gaacatcctt   2460

ccaagaaagg acctatggct tctttattcc gacatacccc aaaataactg catgataaat   2520

aggtctatat ttaaaaagct ctagtgtcga atgttttcaa aataaaattt aattttatga   2580

gattaccctg aatgc                                                    2595


<210>  1536
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  1536

Met Glu Val Arg Thr Lys Arg Pro Arg Ile Gly Thr Asp Thr Asn Arg 
1               5                   10                  15


Pro Phe Val Glu Glu Glu Ile Gln Met Ala Ile Arg Thr Pro Glu Met 
            20                  25                  30


Lys Gly Leu Leu Pro Leu Ala Trp Phe Leu Ala Cys Ser Val Pro Ala 
        35                  40                  45


Val Gln Gly Gly Leu Leu Asp Leu Lys Ser Met Ile Glu Lys Val Thr 
    50                  55                  60


Gly Lys Asn Ala Leu Thr Asn Tyr Gly Phe Tyr Gly Cys Tyr Cys Gly 
65                  70                  75                  80


Trp Gly Gly Arg Gly Thr Pro Lys Asp Gly Thr Asp Trp Cys Cys Trp 
                85                  90                  95


Ala His Asp His Cys Tyr Gly Arg Leu Glu Glu Lys Gly Cys Asn Ile 
            100                 105                 110


Arg Thr Gln Ser Tyr Lys Tyr Arg Phe Ala Trp Gly Val Val Thr Cys 
        115                 120                 125


Glu Pro Gly Pro Phe Cys His Val Asn Leu Cys Ala Cys Asp Arg Lys 
    130                 135                 140


Leu Val Tyr Cys Leu Lys Arg Asn Leu Arg Ser Tyr Asn Pro Gln Tyr 
145                 150                 155                 160


Gln Tyr Phe Pro Asn Ile Leu Cys Ser 
                165


<210>  1537
<211>  1524
<212>  DNA
<213>  Homo sapiens

<400>  1537
atttcacttt aagcacggtc tgtgaaatgg cgggggactt acaaaatggt gcagattgga     60

ctttcttgcc ttctacttta atataaaagg aagaggggcg ttgttgatta tctggctgtt    120

tcctgtcgaa ttaggggcac tgtaaccagg gtttgggttt tgaagtagtg ggtgttcgac    180

tttagagttg ttttcctgga agcgctgata ctggacttag tggaggagaa cgacggtatc    240

aatgtgtttc tggatgactg cctggacaag ggagttcagc ttttgggaga ctgactgggc    300

tatgaagtgt acctttctac tctgcagagg ctggaaaggc aaaaatgatg gctaaggctt    360

ccttgcagcc gctgatacag aagcctgagg gaacacactc ccccctacgt ccttctccaa    420

cacagcagag ccaggaagga cccggatgga agttaggaca aagaggccca gaattggcac    480

agataccaac agaccattcg ttgaagaaga aatccaaatg gccataagaa ccccagagat    540

gaaaggcctc ctcccactgg cttggttcct ggcttgtagt gtgcctgctg tgcaaggagg    600

cttgctggac ctaaaatcaa tgatcgagaa ggtgacaggg aagaacgccc tgacaaacta    660

cggcttctac ggctgttact gcggctgggg cggccgagga acccccaagg atggcaccga    720

ttgggtctca ctctggttgc ccaggctgga gtgcaatggt gcgatctcag ctcactgcat    780

cctagacctt ctgcactcag gtgctgttgg gcgcatgacc actgctatgg gcggctggag    840

gagaagggct gcaacattcg cacacagtcc tacaaataca gattcgcgtg gggcgtggtc    900

acctgcgagc ccgggccctt ctgccatgtg aacctctgtg cctgtgaccg gaagctcgtc    960

tactgcctca agagaaacct acggagctac aacccacagt accaatactt tcccaacatc   1020

ctctgctcct aggcctcccc agcgagctcc tcccagacca agacttttgt tctgtttttc   1080

tacaacacag agtactgact ctgcctggtt cctgagagag gctcctaagt cacagacctc   1140

agtctttctc gaagcttggc ggacccccag ggccacactg taccctccag cgagtcccag   1200

gagagtgact ctggtcatag gacttggtag ggtcccaggg tccctaggcc tccacttctg   1260

agggcagccc ctctggtgcc aagagctctc ctccaactca gggttggctg tgtctctttt   1320

cttctctgaa gacagcgtcc tggctccagt tggaacactt tcctgagatg cacttacttc   1380

tcagcttctg cgatcagatt atcatcacca ccaccctcca gagaattttt acgcaagaag   1440

agccaaattg actctctaaa tctggtgtat gggtattaaa taaaattcat tctcaaggct   1500

aataaaaacc acattggcat tttc                                          1524


<210>  1538
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  1538

Met Glu Val Arg Thr Lys Arg Pro Arg Ile Gly Thr Asp Thr Asn Arg 
1               5                   10                  15


Pro Phe Val Glu Glu Glu Ile Gln Met Ala Ile Arg Thr Pro Glu Met 
            20                  25                  30


Lys Gly Leu Leu Pro Leu Ala Trp Phe Leu Ala Cys Ser Val Pro Ala 
        35                  40                  45


Val Gln Gly Gly Leu Leu Asp Leu Lys Ser Met Ile Glu Lys Val Thr 
    50                  55                  60


Gly Lys Asn Ala Leu Thr Asn Tyr Gly Phe Tyr Gly Cys Tyr Cys Gly 
65                  70                  75                  80


Trp Gly Gly Arg Gly Thr Pro Lys Asp Gly Thr Asp Trp Val Ser Leu 
                85                  90                  95


Trp Leu Pro Arg Leu Glu Cys Asn Gly Ala Ile Ser Ala His Cys Ile 
            100                 105                 110


Leu Asp Leu Leu His Ser Gly Ala Val Gly Arg Met Thr Thr Ala Met 
        115                 120                 125


Gly Gly Trp Arg Arg Arg Ala Ala Thr Phe Ala His Ser Pro Thr Asn 
    130                 135                 140


Thr Asp Ser Arg Gly Ala Trp Ser Pro Ala Ser Pro Gly Pro Ser Ala 
145                 150                 155                 160


Met 



<210>  1539
<211>  1853
<212>  DNA
<213>  Homo sapiens

<400>  1539
atttcacttt aagcacggtc tgtgaaatgg cgggggactt acaaaatggt gcagattgga     60

ctttcttgcc ttctacttta atataaaagg aagaggggcg ttgttgatta tctggctgtt    120

tcctgtcgaa ttaggggcac tgtaaccagg gtttgggttt tgaagtagtg ggtgttcgac    180

tttagagttg ttttcctgga agcgctgata ctggacttag tggaggagaa cgacggtatc    240

aatgtgtttc tggatgactg cctggacaag ggagttcagc ttttgggaga ctgactgggc    300

tatgaagtgt acctttctac tctgcagagg ctggaaaggc aaaaatgatg gctaaggctt    360

ccttgcagcc gctgatacag aagcctgagg gaacacactc ccccctacgt ccttctccaa    420

cacagcagag ccaggaagga cccggatgga agttaggaca aagaggccca gaattggcac    480

agataccaac agaccattcg ttgaagaaga aatccaaatg gccataagct ttaagattct    540

ggaggccaag aatttgactc cccccggatc catggtctgt ggataccaat gttccgactg    600

gagacgggga gcccgcgaga cccgggtctc cagggtctgc ccaaggaagt tgctcatggg    660

agcagacctc tagagcagga tttgaggcca ggccaaagag ggagagaatt cgccgacatc    720

tatttaacat cccttaattg ttgagagcat ccactgtgtg ccagacactt cggtacacac    780

agaaagaaac ccagaggagg aaccccagag atgaaaggcc tcctcccact ggcttggttc    840

ctggcttgta gtgtgcctgc tgtgcaagga ggcttgctgg acctaaaatc aatgatcgag    900

aaggtgacag ggaagaacgc cctgacaaac tacggcttct acggctgtta ctgcggctgg    960

ggcggccgag gaacccccaa ggatggcacc gattgggtct cactctggtt gcccaggctg   1020

gagtgcaatg gtgcgatctc agctcactgc atcctagacc ttctgcactc agggatgggg   1080

tcaggagggc acccctccca ctcgggatct aagtctcttg cacggacagg tgctgttggg   1140

cgcatgacca ctgctatggg cggctggagg agaagggctg caacattcgc acacagtcct   1200

acaaatacag attcgcgtgg ggcgtggtca cctgcgagcc cgggcccttc tgccatgtga   1260

acctctgtgc ctgtgaccgg aagctcgtct actgcctcaa gagaaaccta cggagctaca   1320

acccacagta ccaatacttt cccaacatcc tctgctccta ggcctcccca gcgagctcct   1380

cccagaccaa gacttttgtt ctgtttttct acaacacaga gtactgactc tgcctggttc   1440

ctgagagagg ctcctaagtc acagacctca gtctttctcg aagcttggcg gacccccagg   1500

gccacactgt accctccagc gagtcccagg agagtgactc tggtcatagg acttggtagg   1560

gtcccagggt ccctaggcct ccacttctga gggcagcccc tctggtgcca agagctctcc   1620

tccaactcag ggttggctgt gtctcttttc ttctctgaag acagcgtcct ggctccagtt   1680

ggaacacttt cctgagatgc acttacttct cagcttctgc gatcagatta tcatcaccac   1740

caccctccag agaattttta cgcaagaaga gccaaattga ctctctaaat ctggtgtatg   1800

ggtattaaat aaaattcatt ctcaaggcta ataaaaacca cattggcatt ttc          1853


<210>  1540
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  1540

Met Lys Gly Leu Leu Pro Leu Ala Trp Phe Leu Ala Cys Ser Val Pro 
1               5                   10                  15


Ala Val Gln Gly Gly Leu Leu Asp Leu Lys Ser Met Ile Glu Lys Val 
            20                  25                  30


Thr Gly Lys Asn Ala Leu Thr Asn Tyr Gly Phe Tyr Gly Cys Tyr Cys 
        35                  40                  45


Gly Trp Gly Gly Arg Gly Thr Pro Lys Asp Gly Thr Asp Trp Val Ser 
    50                  55                  60


Leu Trp Leu Pro Arg Leu Glu Cys Asn Gly Ala Ile Ser Ala His Cys 
65                  70                  75                  80


Ile Leu Asp Leu Leu His Ser Gly Met Gly Ser Gly Gly His Pro Ser 
                85                  90                  95


His Ser Gly Ser Lys Ser Leu Ala Arg Thr Gly Ala Val Gly Arg Met 
            100                 105                 110


Thr Thr Ala Met Gly Gly Trp Arg Arg Arg Ala Ala Thr Phe Ala His 
        115                 120                 125


Ser Pro Thr Asn Thr Asp Ser Arg Gly Ala Trp Ser Pro Ala Ser Pro 
    130                 135                 140


Gly Pro Ser Ala Met 
145


<210>  1541
<211>  1504
<212>  DNA
<213>  Homo sapiens

<400>  1541
atttcacttt aagcacggtc tgtgaaatgg cgggggactt acaaaatggt gcagattgga     60

ctttcttgcc ttctacttta atataaaagg aagaggggcg ttgttgatta tctggctgtt    120

tcctgtcgaa ttaggggcac tgtaaccagg gtttgggttt tgaagtagtg ggtgttcgac    180

tttagagttg ttttcctgga agcgctgata ctggacttag tggaggagaa cgacggtatc    240

aatgtgtttc tggatgactg cctggacaag ggagttcagc ttttgggaga ctgactgggc    300

tatgaagtgt acctttctac tctgcagagg ctggaaaggc aaaaatgatg gctaaggctt    360

ccttgcagcc gctgatacag aagcctgagg gaacacactc ccccctacgt ccttctccaa    420

cacagcagag ccaggaagga cccggatgga agttaggaca aagaggccca gaattggcac    480

agataccaac agaccattcg ttgaagaaga aatccaaatg gccataagaa ccccagagat    540

gaaaggcctc ctcccactgg cttggttcct ggcttgtagt gtgcctgctg tgcaaggagg    600

cttgctggac ctaaaatcaa tgatcgagaa ggtgacaggg aagaacgccc tgacaaacta    660

cggcttctac ggctgttact gcggctgggg cggccgagga acccccaagg atggcaccga    720

ttgggatggg gtcaggaggg cacccctccc actcgggatc taagtctctt gcacggacag    780

gtgctgttgg gcgcatgacc actgctatgg gcggctggag gagaagggct gcaacattcg    840

cacacagtcc tacaaataca gattcgcgtg gggcgtggtc acctgcgagc ccgggccctt    900

ctgccatgtg aacctctgtg cctgtgaccg gaagctcgtc tactgcctca agagaaacct    960

acggagctac aacccacagt accaatactt tcccaacatc ctctgctcct aggcctcccc   1020

agcgagctcc tcccagacca agacttttgt tctgtttttc tacaacacag agtactgact   1080

ctgcctggtt cctgagagag gctcctaagt cacagacctc agtctttctc gaagcttggc   1140

ggacccccag ggccacactg taccctccag cgagtcccag gagagtgact ctggtcatag   1200

gacttggtag ggtcccaggg tccctaggcc tccacttctg agggcagccc ctctggtgcc   1260

aagagctctc ctccaactca gggttggctg tgtctctttt cttctctgaa gacagcgtcc   1320

tggctccagt tggaacactt tcctgagatg cacttacttc tcagcttctg cgatcagatt   1380

atcatcacca ccaccctcca gagaattttt acgcaagaag agccaaattg actctctaaa   1440

tctggtgtat gggtattaaa taaaattcat tctcaaggct aataaaaacc acattggcat   1500

tttc                                                                1504


<210>  1542
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  1542

Met Glu Val Arg Thr Lys Arg Pro Arg Ile Gly Thr Asp Thr Asn Arg 
1               5                   10                  15


Pro Phe Val Glu Glu Glu Ile Gln Met Ala Ile Arg Thr Pro Glu Met 
            20                  25                  30


Lys Gly Leu Leu Pro Leu Ala Trp Phe Leu Ala Cys Ser Val Pro Ala 
        35                  40                  45


Val Gln Gly Gly Leu Leu Asp Leu Lys Ser Met Ile Glu Lys Val Thr 
    50                  55                  60


Gly Lys Asn Ala Leu Thr Asn Tyr Gly Phe Tyr Gly Cys Tyr Cys Gly 
65                  70                  75                  80


Trp Gly Gly Arg Gly Thr Pro Lys Asp Gly Thr Asp Trp Asp Gly Val 
                85                  90                  95


Arg Arg Ala Pro Leu Pro Leu Gly Ile 
            100                 105


<210>  1543
<211>  1340
<212>  DNA
<213>  Homo sapiens

<400>  1543
atttcacttt aagcacggtc tgtgaaatgg cgggggactt acaaaatggt gcagattgga     60

ctttcttgcc ttctacttta atataaaagg aagaggggcg ttgttgatta tctggctgtt    120

tcctgtcgaa ttaggggcac tgtaaccagg gtttgggttt tgaagtagtg ggtgttcgac    180

tttagagttg ttttcctgga agcgctgata ctggacttag tggaggagaa cgacggtatc    240

aatgtgtttc tggatgactg cctggacaag ggagttcagc ttttgggaga ctgactgggc    300

tatgaagtgt acctttctac tctgcagagg ctggaaaggc aaaaatgatg gctaaggctt    360

ccttgcagcc gctgatacag aagcctgagg gaacacactc ccccctacgt ccttctccaa    420

cacagcagag ccaggaagga cccggatgga agttaggaca aagaggccca gaattggcac    480

agataccaac agaccattcg ttgaagaaga aatccaaatg gccataagaa ccccagagat    540

gaaaggcctc ctcccactgg cttggttcct ggcttgtagt gtgcctgctg tgcaaggagg    600

cttgctggac ctaaaatcaa tgatcgagaa ggtgacaggg aagaacgccc tgacaaacta    660

cggcttctac ggctgttact gcggctgggg cggccgagga acccccaagg atggcaccga    720

ttgagcccgg gcccttctgc catgtgaacc tctgtgcctg tgaccggaag ctcgtctact    780

gcctcaagag aaacctacgg agctacaacc cacagtacca atactttccc aacatcctct    840

gctcctaggc ctccccagcg agctcctccc agaccaagac ttttgttctg tttttctaca    900

acacagagta ctgactctgc ctggttcctg agagaggctc ctaagtcaca gacctcagtc    960

tttctcgaag cttggcggac ccccagggcc acactgtacc ctccagcgag tcccaggaga   1020

gtgactctgg tcataggact tggtagggtc ccagggtccc taggcctcca cttctgaggg   1080

cagcccctct ggtgccaaga gctctcctcc aactcagggt tggctgtgtc tcttttcttc   1140

tctgaagaca gcgtcctggc tccagttgga acactttcct gagatgcact tacttctcag   1200

cttctgcgat cagattatca tcaccaccac cctccagaga atttttacgc aagaagagcc   1260

aaattgactc tctaaatctg gtgtatgggt attaaataaa attcattctc aaggctaata   1320

aaaaccacat tggcattttc                                               1340


<210>  1544
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  1544

Met Glu Val Arg Thr Lys Arg Pro Arg Ile Gly Thr Asp Thr Asn Arg 
1               5                   10                  15


Pro Phe Val Glu Glu Glu Ile Gln Met Ala Ile Arg Thr Pro Glu Met 
            20                  25                  30


Lys Gly Leu Leu Pro Leu Ala Trp Phe Leu Ala Cys Ser Val Pro Ala 
        35                  40                  45


Val Gln Gly Gly Leu Leu Asp Leu Lys Ser Met Ile Glu Lys Val Thr 
    50                  55                  60


Gly Lys Asn Ala Leu Thr Asn Tyr Gly Phe Tyr Gly Cys Tyr Cys Gly 
65                  70                  75                  80


Trp Gly Gly Arg Gly Thr Pro Lys Asp Gly Thr Asp 
                85                  90


<210>  1545
<211>  1619
<212>  DNA
<213>  Homo sapiens

<400>  1545
atttcacttt aagcacggtc tgtgaaatgg cgggggactt acaaaatggt gcagattgga     60

ctttcttgcc ttctacttta atataaaagg aagaggggcg ttgttgatta tctggctgtt    120

tcctgtcgaa ttaggggcac tgtaaccagg gtttgggttt tgaagtagtg ggtgttcgac    180

tttagagttg ttttcctgga agcgctgata ctggacttag tggaggagaa cgacggtatc    240

aatgtgtttc tggatgactg cctggacaag ggagttcagc ttttgggaga ctgactgggc    300

tatgaagtgt acctttctac tctgcagagg ctggaaaggc aaaaatgatg gctaaggctt    360

ccttgcagcc gctgatacag aagcctgagg gaacacactc ccccctacgt ccttctccaa    420

cacagcagag ccaggaagga cccggatgga agttaggaca aagaggccca gaattggcac    480

agataccaac agaccattcg ttgaagaaga aatccaaatg gccataagct ttaagattct    540

ggaggccaag aatttgactc cccccggatc catggtctgt ggataccaat gttccgactg    600

gagacgggga gcccgcgaga cccgggtctc cagggtctgc ccaaggaagt tgctcatggg    660

agcagacctc tagagcagga tttgaggcca ggccaaagag aaccccagag atgaaaggcc    720

tcctcccact ggcttggttc ctggcttgta gtgtgcctgc tgtgcaagga ggcttgctgg    780

acctaaaatc aatgatcgag aaggtgacag ggaagaacgc cctgacaaac tacggcttct    840

acggctgtta ctgcggctgg ggcggccgag gaacccccaa ggatggcacc gattggtgct    900

gttgggcgca tgaccactgc tatgggcggc tggaggagaa gggctgcaac attcgcacac    960

agtcctacaa atacagattc gcgtggggcg tggtcacctg cgagcccggg cccttctgcc   1020

atgtgaacct ctgtgcctgt gaccggaagc tcgtctactg cctcaagaga aacctacgga   1080

gctacaaccc acagtaccaa tactttccca acatcctctg ctcctaggcc tccccagcga   1140

gctcctccca gaccaagact tttgttctgt ttttctacaa cacagagtac tgactctgcc   1200

tggttcctga gagaggctcc taagtcacag acctcagtct ttctcgaagc ttggcggacc   1260

cccagggcca cactgtaccc tccagcgagt cccaggagag tgactctggt cataggactt   1320

ggtagggtcc cagggtccct aggcctccac ttctgagggc agcccctctg gtgccaagag   1380

ctctcctcca actcagggtt ggctgtgtct cttttcttct ctgaagacag cgtcctggct   1440

ccagttggaa cactttcctg agatgcactt acttctcagc ttctgcgatc agattatcat   1500

caccaccacc ctccagagaa tttttacgca agaagagcca aattgactct ctaaatctgg   1560

tgtatgggta ttaaataaaa ttcattctca aggctaataa aaaccacatt ggcattttc    1619


<210>  1546
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  1546

Met Lys Gly Leu Leu Pro Leu Ala Trp Phe Leu Ala Cys Ser Val Pro 
1               5                   10                  15


Ala Val Gln Gly Gly Leu Leu Asp Leu Lys Ser Met Ile Glu Lys Val 
            20                  25                  30


Thr Gly Lys Asn Ala Leu Thr Asn Tyr Gly Phe Tyr Gly Cys Tyr Cys 
        35                  40                  45


Gly Trp Gly Gly Arg Gly Thr Pro Lys Asp Gly Thr Asp Trp Cys Cys 
    50                  55                  60


Trp Ala His Asp His Cys Tyr Gly Arg Leu Glu Glu Lys Gly Cys Asn 
65                  70                  75                  80


Ile Arg Thr Gln Ser Tyr Lys Tyr Arg Phe Ala Trp Gly Val Val Thr 
                85                  90                  95


Cys Glu Pro Gly Pro Phe Cys His Val Asn Leu Cys Ala Cys Asp Arg 
            100                 105                 110


Lys Leu Val Tyr Cys Leu Lys Arg Asn Leu Arg Ser Tyr Asn Pro Gln 
        115                 120                 125


Tyr Gln Tyr Phe Pro Asn Ile Leu Cys Ser 
    130                 135


<210>  1547
<211>  2583
<212>  DNA
<213>  Homo sapiens

<400>  1547
atttcacttt aagcacggtc tgtgaaatgg cgggggactt acaaaatggt gcagattgga     60

ctttcttgcc ttctacttta atataaaagg aagaggggcg ttgttgatta tctggctgtt    120

tcctgtcgaa ttaggggcac tgtaaccagg gtttgggttt tgaagtagtg ggtgttcgac    180

tttagagttg ttttcctgga agcgctgata ctggacttag tggaggagaa cgacggtatc    240

aatgtgtttc tggatgactg cctggacaag ggagttcagc ttttgggaga ctgactgggc    300

tatgaagtgt acctttctac tctgcagagg ctggaaaggc aaaaatgatg gctaaggctt    360

ccttgcagcc gctgatacag aagcctgagg gaacacactc ccccctacgt ccttctccaa    420

cacagcagag ccaggaagga cccggatgga agttaggaca aagaggccca gaattggcac    480

agataccaac agaccattcg ttgaagaaga aatccaaatg gccataagct ttaagattct    540

ggaggccaag aatttgactc cccccggatc catggtctgt ggataccaat gttccgactg    600

gagacgggga gcccgcgaga cccgggtctc cagggtctgc ccaaggaagt tgctcatggg    660

agcagacctc tagagcagga tttgaggcca ggccaaagag ggagagaatt cgccgacatc    720

tatttaacat cccttaattg ttgagagcat ccactgtgtg ccagacactt cggtacacac    780

agaaagaaac ccagaggagg aaccccagag atgaaaggcc tcctcccact ggcttggttc    840

ctggcttgta gtgtgcctgc tgtgcaagga ggcttgctgg acctaaaatc aatgatcgag    900

aaggtgacag ggaagaacgc cctgacaaac tacggcttct acggctgtta ctgcggctgg    960

ggcggccgag gaacccccaa ggatggcacc gattgggtct cactctggtt gcccaggctg   1020

gagtgcaatg gtgcgatctc agctcactgc atcctagacc ttctgcactc agggatgggg   1080

tcaggagggc acccctccca ctcgggatct aagtctcttg cacggacagg tgctgttggg   1140

cgcatgacca ctgctatggg cggctggagg agaagggctg caacattcgc acacagtcct   1200

acaaatacag attcgcgtgg ggcgtggtca cctgcgagcc cgggcccttc tgccatgtga   1260

acctctgtgc ctgtgaccgg aagctcgtct actgcctcaa gagaaaccta cggagctaca   1320

acccacagta ccaatacttt cccaacatcc tctgctccta ggcctcccca gcgagctcct   1380

cccagaccaa gacttttgtt ctgtttttct acaacacaga gtactgactc tgcctggttc   1440

ctgagagagg ctcctaagtc acagacctca gtctttctcg aagcttggcg gacccccagg   1500

gccacactgt accctccagc gagtcccagg agagtgactc tggtcatagg acttggtagg   1560

gtcccagggt ccctaggcct ccacttctga gggcagcccc tctggtgcca agagctctcc   1620

tccaactcag ggttggctgt gtctcttttc ttctctgaag acagcgtcct ggctccagtt   1680

ggaacacttt cctgagatgc acttacttct cagcttctgc gatcagatta tcatcaccac   1740

caccctccag agaattttta cgcaagaaga gccaaattga ctctctaaat ctggtgtatg   1800

ggtattaaat aaaattcatt ctcaaggcta ataaaaacca cattggcatt ttcctctgct   1860

gtgggggatc gctggtgcct ctttctctgc cactggggca ataaacccaa agatgtctac   1920

attatctccg aaacagaagg gaagattagt aaatgcaggg ttttctggga tgagcttcag   1980

gctttctctt gggctaattt tcttacacct tggggtcctc tccagtattg ggtctcattc   2040

ttcctcgatg gggtcaggga aagataactg gtgattatgc cagcttcagc ttccaggcca   2100

gagagggtgg cattcaaatc ccagtgctgg cttcttcagc tgtgtggtct tggacccgtt   2160

actgaacctc tttgactttc agtctctttg agaaataaac tgtcttgttc cttgcaatgt   2220

aaaatgagac ttctaaagcc caccttgatg ctgatatgga gaatgctgag gttctaggat   2280

ttcacacagc aggaattttt ttttaatagg tgtcagctgt ggggtttatt ttttacaaag   2340

taaggacatt aaaaaaacca acccgtctat caattcataa aagaaaggat gttctgatac   2400

caagactgaa agaagaaagg atgtattcca aaacaaagga acatccttcc aagaaaggac   2460

ctatggcttc tttattccga cataccccaa aataactgca tgataaatag gtctatattt   2520

aaaaagctct agtgtcgaat gttttcaaaa taaaatttaa ttttatgaga ttaccctgaa   2580

tgc                                                                 2583


<210>  1548
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  1548

Met Lys Gly Leu Leu Pro Leu Ala Trp Phe Leu Ala Cys Ser Val Pro 
1               5                   10                  15


Ala Val Gln Gly Gly Leu Leu Asp Leu Lys Ser Met Ile Glu Lys Val 
            20                  25                  30


Thr Gly Lys Asn Ala Leu Thr Asn Tyr Gly Phe Tyr Gly Cys Tyr Cys 
        35                  40                  45


Gly Trp Gly Gly Arg Gly Thr Pro Lys Asp Gly Thr Asp Trp Val Ser 
    50                  55                  60


Leu Trp Leu Pro Arg Leu Glu Cys Asn Gly Ala Ile Ser Ala His Cys 
65                  70                  75                  80


Ile Leu Asp Leu Leu His Ser Gly Met Gly Ser Gly Gly His Pro Ser 
                85                  90                  95


His Ser Gly Ser Lys Ser Leu Ala Arg Thr Gly Ala Val Gly Arg Met 
            100                 105                 110


Thr Thr Ala Met Gly Gly Trp Arg Arg Arg Ala Ala Thr Phe Ala His 
        115                 120                 125


Ser Pro Thr Asn Thr Asp Ser Arg Gly Ala Trp Ser Pro Ala Ser Pro 
    130                 135                 140


Gly Pro Ser Ala Met 
145


<210>  1549
<211>  2234
<212>  DNA
<213>  Homo sapiens

<400>  1549
atttcacttt aagcacggtc tgtgaaatgg cgggggactt acaaaatggt gcagattgga     60

ctttcttgcc ttctacttta atataaaagg aagaggggcg ttgttgatta tctggctgtt    120

tcctgtcgaa ttaggggcac tgtaaccagg gtttgggttt tgaagtagtg ggtgttcgac    180

tttagagttg ttttcctgga agcgctgata ctggacttag tggaggagaa cgacggtatc    240

aatgtgtttc tggatgactg cctggacaag ggagttcagc ttttgggaga ctgactgggc    300

tatgaagtgt acctttctac tctgcagagg ctggaaaggc aaaaatgatg gctaaggctt    360

ccttgcagcc gctgatacag aagcctgagg gaacacactc ccccctacgt ccttctccaa    420

cacagcagag ccaggaagga cccggatgga agttaggaca aagaggccca gaattggcac    480

agataccaac agaccattcg ttgaagaaga aatccaaatg gccataagaa ccccagagat    540

gaaaggcctc ctcccactgg cttggttcct ggcttgtagt gtgcctgctg tgcaaggagg    600

cttgctggac ctaaaatcaa tgatcgagaa ggtgacaggg aagaacgccc tgacaaacta    660

cggcttctac ggctgttact gcggctgggg cggccgagga acccccaagg atggcaccga    720

ttgggatggg gtcaggaggg cacccctccc actcgggatc taagtctctt gcacggacag    780

gtgctgttgg gcgcatgacc actgctatgg gcggctggag gagaagggct gcaacattcg    840

cacacagtcc tacaaataca gattcgcgtg gggcgtggtc acctgcgagc ccgggccctt    900

ctgccatgtg aacctctgtg cctgtgaccg gaagctcgtc tactgcctca agagaaacct    960

acggagctac aacccacagt accaatactt tcccaacatc ctctgctcct aggcctcccc   1020

agcgagctcc tcccagacca agacttttgt tctgtttttc tacaacacag agtactgact   1080

ctgcctggtt cctgagagag gctcctaagt cacagacctc agtctttctc gaagcttggc   1140

ggacccccag ggccacactg taccctccag cgagtcccag gagagtgact ctggtcatag   1200

gacttggtag ggtcccaggg tccctaggcc tccacttctg agggcagccc ctctggtgcc   1260

aagagctctc ctccaactca gggttggctg tgtctctttt cttctctgaa gacagcgtcc   1320

tggctccagt tggaacactt tcctgagatg cacttacttc tcagcttctg cgatcagatt   1380

atcatcacca ccaccctcca gagaattttt acgcaagaag agccaaattg actctctaaa   1440

tctggtgtat gggtattaaa taaaattcat tctcaaggct aataaaaacc acattggcat   1500

tttcctctgc tgtgggggat cgctggtgcc tctttctctg ccactggggc aataaaccca   1560

aagatgtcta cattatctcc gaaacagaag ggaagattag taaatgcagg gttttctggg   1620

atgagcttca ggctttctct tgggctaatt ttcttacacc ttggggtcct ctccagtatt   1680

gggtctcatt cttcctcgat ggggtcaggg aaagataact ggtgattatg ccagcttcag   1740

cttccaggcc agagagggtg gcattcaaat cccagtgctg gcttcttcag ctgtgtggtc   1800

ttggacccgt tactgaacct ctttgacttt cagtctcttt gagaaataaa ctgtcttgtt   1860

ccttgcaatg taaaatgaga cttctaaagc ccaccttgat gctgatatgg agaatgctga   1920

ggttctagga tttcacacag caggaatttt tttttaatag gtgtcagctg tggggtttat   1980

tttttacaaa gtaaggacat taaaaaaacc aacccgtcta tcaattcata aaagaaagga   2040

tgttctgata ccaagactga aagaagaaag gatgtattcc aaaacaaagg aacatccttc   2100

caagaaagga cctatggctt ctttattccg acatacccca aaataactgc atgataaata   2160

ggtctatatt taaaaagctc tagtgtcgaa tgttttcaaa ataaaattta attttatgag   2220

attaccctga atgc                                                     2234


<210>  1550
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  1550

Met Glu Val Arg Thr Lys Arg Pro Arg Ile Gly Thr Asp Thr Asn Arg 
1               5                   10                  15


Pro Phe Val Glu Glu Glu Ile Gln Met Ala Ile Arg Thr Pro Glu Met 
            20                  25                  30


Lys Gly Leu Leu Pro Leu Ala Trp Phe Leu Ala Cys Ser Val Pro Ala 
        35                  40                  45


Val Gln Gly Gly Leu Leu Asp Leu Lys Ser Met Ile Glu Lys Val Thr 
    50                  55                  60


Gly Lys Asn Ala Leu Thr Asn Tyr Gly Phe Tyr Gly Cys Tyr Cys Gly 
65                  70                  75                  80


Trp Gly Gly Arg Gly Thr Pro Lys Asp Gly Thr Asp Trp Asp Gly Val 
                85                  90                  95


Arg Arg Ala Pro Leu Pro Leu Gly Ile 
            100                 105


<210>  1551
<211>  2070
<212>  DNA
<213>  Homo sapiens

<400>  1551
atttcacttt aagcacggtc tgtgaaatgg cgggggactt acaaaatggt gcagattgga     60

ctttcttgcc ttctacttta atataaaagg aagaggggcg ttgttgatta tctggctgtt    120

tcctgtcgaa ttaggggcac tgtaaccagg gtttgggttt tgaagtagtg ggtgttcgac    180

tttagagttg ttttcctgga agcgctgata ctggacttag tggaggagaa cgacggtatc    240

aatgtgtttc tggatgactg cctggacaag ggagttcagc ttttgggaga ctgactgggc    300

tatgaagtgt acctttctac tctgcagagg ctggaaaggc aaaaatgatg gctaaggctt    360

ccttgcagcc gctgatacag aagcctgagg gaacacactc ccccctacgt ccttctccaa    420

cacagcagag ccaggaagga cccggatgga agttaggaca aagaggccca gaattggcac    480

agataccaac agaccattcg ttgaagaaga aatccaaatg gccataagaa ccccagagat    540

gaaaggcctc ctcccactgg cttggttcct ggcttgtagt gtgcctgctg tgcaaggagg    600

cttgctggac ctaaaatcaa tgatcgagaa ggtgacaggg aagaacgccc tgacaaacta    660

cggcttctac ggctgttact gcggctgggg cggccgagga acccccaagg atggcaccga    720

ttgagcccgg gcccttctgc catgtgaacc tctgtgcctg tgaccggaag ctcgtctact    780

gcctcaagag aaacctacgg agctacaacc cacagtacca atactttccc aacatcctct    840

gctcctaggc ctccccagcg agctcctccc agaccaagac ttttgttctg tttttctaca    900

acacagagta ctgactctgc ctggttcctg agagaggctc ctaagtcaca gacctcagtc    960

tttctcgaag cttggcggac ccccagggcc acactgtacc ctccagcgag tcccaggaga   1020

gtgactctgg tcataggact tggtagggtc ccagggtccc taggcctcca cttctgaggg   1080

cagcccctct ggtgccaaga gctctcctcc aactcagggt tggctgtgtc tcttttcttc   1140

tctgaagaca gcgtcctggc tccagttgga acactttcct gagatgcact tacttctcag   1200

cttctgcgat cagattatca tcaccaccac cctccagaga atttttacgc aagaagagcc   1260

aaattgactc tctaaatctg gtgtatgggt attaaataaa attcattctc aaggctaata   1320

aaaaccacat tggcattttc ctctgctgtg ggggatcgct ggtgcctctt tctctgccac   1380

tggggcaata aacccaaaga tgtctacatt atctccgaaa cagaagggaa gattagtaaa   1440

tgcagggttt tctgggatga gcttcaggct ttctcttggg ctaattttct tacaccttgg   1500

ggtcctctcc agtattgggt ctcattcttc ctcgatgggg tcagggaaag ataactggtg   1560

attatgccag cttcagcttc caggccagag agggtggcat tcaaatccca gtgctggctt   1620

cttcagctgt gtggtcttgg acccgttact gaacctcttt gactttcagt ctctttgaga   1680

aataaactgt cttgttcctt gcaatgtaaa atgagacttc taaagcccac cttgatgctg   1740

atatggagaa tgctgaggtt ctaggatttc acacagcagg aatttttttt taataggtgt   1800

cagctgtggg gtttattttt tacaaagtaa ggacattaaa aaaaccaacc cgtctatcaa   1860

ttcataaaag aaaggatgtt ctgataccaa gactgaaaga agaaaggatg tattccaaaa   1920

caaaggaaca tccttccaag aaaggaccta tggcttcttt attccgacat accccaaaat   1980

aactgcatga taaataggtc tatatttaaa aagctctagt gtcgaatgtt ttcaaaataa   2040

aatttaattt tatgagatta ccctgaatgc                                    2070


<210>  1552
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  1552

Met Glu Val Arg Thr Lys Arg Pro Arg Ile Gly Thr Asp Thr Asn Arg 
1               5                   10                  15


Pro Phe Val Glu Glu Glu Ile Gln Met Ala Ile Arg Thr Pro Glu Met 
            20                  25                  30


Lys Gly Leu Leu Pro Leu Ala Trp Phe Leu Ala Cys Ser Val Pro Ala 
        35                  40                  45


Val Gln Gly Gly Leu Leu Asp Leu Lys Ser Met Ile Glu Lys Val Thr 
    50                  55                  60


Gly Lys Asn Ala Leu Thr Asn Tyr Gly Phe Tyr Gly Cys Tyr Cys Gly 
65                  70                  75                  80


Trp Gly Gly Arg Gly Thr Pro Lys Asp Gly Thr Asp 
                85                  90


<210>  1553
<211>  2254
<212>  DNA
<213>  Homo sapiens

<400>  1553
atttcacttt aagcacggtc tgtgaaatgg cgggggactt acaaaatggt gcagattgga     60

ctttcttgcc ttctacttta atataaaagg aagaggggcg ttgttgatta tctggctgtt    120

tcctgtcgaa ttaggggcac tgtaaccagg gtttgggttt tgaagtagtg ggtgttcgac    180

tttagagttg ttttcctgga agcgctgata ctggacttag tggaggagaa cgacggtatc    240

aatgtgtttc tggatgactg cctggacaag ggagttcagc ttttgggaga ctgactgggc    300

tatgaagtgt acctttctac tctgcagagg ctggaaaggc aaaaatgatg gctaaggctt    360

ccttgcagcc gctgatacag aagcctgagg gaacacactc ccccctacgt ccttctccaa    420

cacagcagag ccaggaagga cccggatgga agttaggaca aagaggccca gaattggcac    480

agataccaac agaccattcg ttgaagaaga aatccaaatg gccataagaa ccccagagat    540

gaaaggcctc ctcccactgg cttggttcct ggcttgtagt gtgcctgctg tgcaaggagg    600

cttgctggac ctaaaatcaa tgatcgagaa ggtgacaggg aagaacgccc tgacaaacta    660

cggcttctac ggctgttact gcggctgggg cggccgagga acccccaagg atggcaccga    720

ttgggtctca ctctggttgc ccaggctgga gtgcaatggt gcgatctcag ctcactgcat    780

cctagacctt ctgcactcag gtgctgttgg gcgcatgacc actgctatgg gcggctggag    840

gagaagggct gcaacattcg cacacagtcc tacaaataca gattcgcgtg gggcgtggtc    900

acctgcgagc ccgggccctt ctgccatgtg aacctctgtg cctgtgaccg gaagctcgtc    960

tactgcctca agagaaacct acggagctac aacccacagt accaatactt tcccaacatc   1020

ctctgctcct aggcctcccc agcgagctcc tcccagacca agacttttgt tctgtttttc   1080

tacaacacag agtactgact ctgcctggtt cctgagagag gctcctaagt cacagacctc   1140

agtctttctc gaagcttggc ggacccccag ggccacactg taccctccag cgagtcccag   1200

gagagtgact ctggtcatag gacttggtag ggtcccaggg tccctaggcc tccacttctg   1260

agggcagccc ctctggtgcc aagagctctc ctccaactca gggttggctg tgtctctttt   1320

cttctctgaa gacagcgtcc tggctccagt tggaacactt tcctgagatg cacttacttc   1380

tcagcttctg cgatcagatt atcatcacca ccaccctcca gagaattttt acgcaagaag   1440

agccaaattg actctctaaa tctggtgtat gggtattaaa taaaattcat tctcaaggct   1500

aataaaaacc acattggcat tttcctctgc tgtgggggat cgctggtgcc tctttctctg   1560

ccactggggc aataaaccca aagatgtcta cattatctcc gaaacagaag ggaagattag   1620

taaatgcagg gttttctggg atgagcttca ggctttctct tgggctaatt ttcttacacc   1680

ttggggtcct ctccagtatt gggtctcatt cttcctcgat ggggtcaggg aaagataact   1740

ggtgattatg ccagcttcag cttccaggcc agagagggtg gcattcaaat cccagtgctg   1800

gcttcttcag ctgtgtggtc ttggacccgt tactgaacct ctttgacttt cagtctcttt   1860

gagaaataaa ctgtcttgtt ccttgcaatg taaaatgaga cttctaaagc ccaccttgat   1920

gctgatatgg agaatgctga ggttctagga tttcacacag caggaatttt tttttaatag   1980

gtgtcagctg tggggtttat tttttacaaa gtaaggacat taaaaaaacc aacccgtcta   2040

tcaattcata aaagaaagga tgttctgata ccaagactga aagaagaaag gatgtattcc   2100

aaaacaaagg aacatccttc caagaaagga cctatggctt ctttattccg acatacccca   2160

aaataactgc atgataaata ggtctatatt taaaaagctc tagtgtcgaa tgttttcaaa   2220

ataaaattta attttatgag attaccctga atgc                               2254


<210>  1554
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  1554

Met Glu Val Arg Thr Lys Arg Pro Arg Ile Gly Thr Asp Thr Asn Arg 
1               5                   10                  15


Pro Phe Val Glu Glu Glu Ile Gln Met Ala Ile Arg Thr Pro Glu Met 
            20                  25                  30


Lys Gly Leu Leu Pro Leu Ala Trp Phe Leu Ala Cys Ser Val Pro Ala 
        35                  40                  45


Val Gln Gly Gly Leu Leu Asp Leu Lys Ser Met Ile Glu Lys Val Thr 
    50                  55                  60


Gly Lys Asn Ala Leu Thr Asn Tyr Gly Phe Tyr Gly Cys Tyr Cys Gly 
65                  70                  75                  80


Trp Gly Gly Arg Gly Thr Pro Lys Asp Gly Thr Asp Trp Val Ser Leu 
                85                  90                  95


Trp Leu Pro Arg Leu Glu Cys Asn Gly Ala Ile Ser Ala His Cys Ile 
            100                 105                 110


Leu Asp Leu Leu His Ser Gly Ala Val Gly Arg Met Thr Thr Ala Met 
        115                 120                 125


Gly Gly Trp Arg Arg Arg Ala Ala Thr Phe Ala His Ser Pro Thr Asn 
    130                 135                 140


Thr Asp Ser Arg Gly Ala Trp Ser Pro Ala Ser Pro Gly Pro Ser Ala 
145                 150                 155                 160


Met 



<210>  1555
<211>  2349
<212>  DNA
<213>  Homo sapiens

<400>  1555
atttcacttt aagcacggtc tgtgaaatgg cgggggactt acaaaatggt gcagattgga     60

ctttcttgcc ttctacttta atataaaagg aagaggggcg ttgttgatta tctggctgtt    120

tcctgtcgaa ttaggggcac tgtaaccagg gtttgggttt tgaagtagtg ggtgttcgac    180

tttagagttg ttttcctgga agcgctgata ctggacttag tggaggagaa cgacggtatc    240

aatgtgtttc tggatgactg cctggacaag ggagttcagc ttttgggaga ctgactgggc    300

tatgaagtgt acctttctac tctgcagagg ctggaaaggc aaaaatgatg gctaaggctt    360

ccttgcagcc gctgatacag aagcctgagg gaacacactc ccccctacgt ccttctccaa    420

cacagcagag ccaggaagga cccggatgga agttaggaca aagaggccca gaattggcac    480

agataccaac agaccattcg ttgaagaaga aatccaaatg gccataagct ttaagattct    540

ggaggccaag aatttgactc cccccggatc catggtctgt ggataccaat gttccgactg    600

gagacgggga gcccgcgaga cccgggtctc cagggtctgc ccaaggaagt tgctcatggg    660

agcagacctc tagagcagga tttgaggcca ggccaaagag aaccccagag atgaaaggcc    720

tcctcccact ggcttggttc ctggcttgta gtgtgcctgc tgtgcaagga ggcttgctgg    780

acctaaaatc aatgatcgag aaggtgacag ggaagaacgc cctgacaaac tacggcttct    840

acggctgtta ctgcggctgg ggcggccgag gaacccccaa ggatggcacc gattggtgct    900

gttgggcgca tgaccactgc tatgggcggc tggaggagaa gggctgcaac attcgcacac    960

agtcctacaa atacagattc gcgtggggcg tggtcacctg cgagcccggg cccttctgcc   1020

atgtgaacct ctgtgcctgt gaccggaagc tcgtctactg cctcaagaga aacctacgga   1080

gctacaaccc acagtaccaa tactttccca acatcctctg ctcctaggcc tccccagcga   1140

gctcctccca gaccaagact tttgttctgt ttttctacaa cacagagtac tgactctgcc   1200

tggttcctga gagaggctcc taagtcacag acctcagtct ttctcgaagc ttggcggacc   1260

cccagggcca cactgtaccc tccagcgagt cccaggagag tgactctggt cataggactt   1320

ggtagggtcc cagggtccct aggcctccac ttctgagggc agcccctctg gtgccaagag   1380

ctctcctcca actcagggtt ggctgtgtct cttttcttct ctgaagacag cgtcctggct   1440

ccagttggaa cactttcctg agatgcactt acttctcagc ttctgcgatc agattatcat   1500

caccaccacc ctccagagaa tttttacgca agaagagcca aattgactct ctaaatctgg   1560

tgtatgggta ttaaataaaa ttcattctca aggctaataa aaaccacatt ggcattttcc   1620

tctgctgtgg gggatcgctg gtgcctcttt ctctgccact ggggcaataa acccaaagat   1680

gtctacatta tctccgaaac agaagggaag attagtaaat gcagggtttt ctgggatgag   1740

cttcaggctt tctcttgggc taattttctt acaccttggg gtcctctcca gtattgggtc   1800

tcattcttcc tcgatggggt cagggaaaga taactggtga ttatgccagc ttcagcttcc   1860

aggccagaga gggtggcatt caaatcccag tgctggcttc ttcagctgtg tggtcttgga   1920

cccgttactg aacctctttg actttcagtc tctttgagaa ataaactgtc ttgttccttg   1980

caatgtaaaa tgagacttct aaagcccacc ttgatgctga tatggagaat gctgaggttc   2040

taggatttca cacagcagga attttttttt aataggtgtc agctgtgggg tttatttttt   2100

acaaagtaag gacattaaaa aaaccaaccc gtctatcaat tcataaaaga aaggatgttc   2160

tgataccaag actgaaagaa gaaaggatgt attccaaaac aaaggaacat ccttccaaga   2220

aaggacctat ggcttcttta ttccgacata ccccaaaata actgcatgat aaataggtct   2280

atatttaaaa agctctagtg tcgaatgttt tcaaaataaa atttaatttt atgagattac   2340

cctgaatgc                                                           2349


<210>  1556
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  1556

Met Lys Gly Leu Leu Pro Leu Ala Trp Phe Leu Ala Cys Ser Val Pro 
1               5                   10                  15


Ala Val Gln Gly Gly Leu Leu Asp Leu Lys Ser Met Ile Glu Lys Val 
            20                  25                  30


Thr Gly Lys Asn Ala Leu Thr Asn Tyr Gly Phe Tyr Gly Cys Tyr Cys 
        35                  40                  45


Gly Trp Gly Gly Arg Gly Thr Pro Lys Asp Gly Thr Asp Trp Cys Cys 
    50                  55                  60


Trp Ala His Asp His Cys Tyr Gly Arg Leu Glu Glu Lys Gly Cys Asn 
65                  70                  75                  80


Ile Arg Thr Gln Ser Tyr Lys Tyr Arg Phe Ala Trp Gly Val Val Thr 
                85                  90                  95


Cys Glu Pro Gly Pro Phe Cys His Val Asn Leu Cys Ala Cys Asp Arg 
            100                 105                 110


Lys Leu Val Tyr Cys Leu Lys Arg Asn Leu Arg Ser Tyr Asn Pro Gln 
        115                 120                 125


Tyr Gln Tyr Phe Pro Asn Ile Leu Cys Ser 
    130                 135


<210>  1557
<211>  3137
<212>  DNA
<213>  Homo sapiens

<400>  1557
gcctgagaca catggaattt cctggactct aagctggcaa tggctgtttt taccaaagac     60

agattctaag gagtgaagcc aagggctctg gcctgagagg tagagcatga gaaggaacaa    120

acacagaccc ctaaaggatt catgcctctg ggaaaagcca ctggcacatt gtgggagccc    180

aggcttcaca ctgtgagcta aaaggagtat gagatgtaga atcaccggct ttccttctgc    240

cctcctgctg tgggcgtcaa gtgctctctg tccaggaatt tttttcttcc gtcttacatc    300

tttcatcaaa ggccatgtct aggttatatc aagtcctgct tctccacgta tgccaccaaa    360

tctccattta agaatcctgc ccattctctg gtccctttta gccattttgc caacggggtg    420

agtatgtctg gggtgtttgt ggctaaaagt gcactggtgg tagggacagt gtccctgcaa    480

atgcttccat tattgtccct ctgcctccag ggccctcagt ggacctacag ttttttgcct    540

catcttttct ggctggactc atcttgttta ttgcccacca tgacggggag tggaatagat    600

ggggcctggt ggagagccag ggtgggatct gaatgggcca cgggggcatt gcctgataga    660

tctgttgtgg gatgtgtttt tttttccaga accccagaga tgaaaggcct cctcccactg    720

gcttggttcc tggcttgtag taagtgctgg ccccgtgacc ttcgaatgaa cttttacccc    780

atgcctcagc tgtgtaaagg ttgtggacat agaggttatg tggctggcaa gtgtaggagg    840

cagatttttt ccctgtatgc aaataaaata agatttacaa aatcccccaa tcaatccaaa    900

taaaaatcaa aactcttatc taaatatccc aacctatgat tcctgggtca ttctcagctc    960

aggcttgtcc agctgggaag tgactgtata gatggcttta gtcccatcct gcggccccgt   1020

gaccgtatat acaacccccg acaggctgtc ctgctccttg atgtcttgct agatccctgg   1080

agactccagg aggagctgga ggcctggtgc aaggagagag ccttgggcct tatgttctaa   1140

agggtgtgag gggagggagt ggtggggaag agggatgtat tgccaagaga gacaggaagc   1200

tcctatctgc ctgcttcatg caaatacatt atgaattaca ccttatatgt catggtttgc   1260

acctcccttc ccactaatgg agagaataaa aaagagacat gcaggtccct ccaagccctg   1320

ggtgggagaa agggtaggag atgttgggca gtgggcctaa agcagggctg ggctgcctgg   1380

gtgtcacctg gggacatggg ctatcttcca ggtgtgcctg ctgtgcaagg aggcttgctg   1440

gacctaaaat caatgatcga gaaggtgaca gggaagaacg ccctgacaaa ctacggcttc   1500

tacggctgtt actgcggctg gggcggccga ggaaccccca aggatggcac cgattggtga   1560

gctgatcgct ataactgccc tttaggctcc agtacttttt atgtgcaatc tgctacacct   1620

aacatagtgt gatcatatac atatacgttt ttttttagaa gtttatttct ggatcacata   1680

acagttcagt aggaatcaca cgttgggtcc atgacctgct ggctagaaat gaggagcagg   1740

aaattactca gtcacactac cagatcctcc ctgccacatc gcgtccacca aggtggcctc   1800

tgctaaagtg acatggttga atttttgctc ctattaggga tggggtcagg agggcacccc   1860

tcccactcgg gatctaagtc tcttgcacgg acaggtgctg ttgggcgcat gaccactgct   1920

atgggcggct ggaggagaag ggctgcaaca ttcgcacaca gtcctacaaa tacagattcg   1980

cgtggggcgt ggtcacctgc ggtaaggctg gggcttcccg ttcgggccat tggaagagca   2040

cctgacttta agttcagctg ccctagagaa cagccagcct gtatcttgtt gggggaggag   2100

gagttgggtg cagaactggg acgagaggag caggattatt gcagctgtat cagaccccca   2160

gggtagggct gaatcatcca ctgggtgcaa taaatctggg gatggttctg ctctatgaga   2220

atgagagttc ctccagagca gcggctgcct ccaccatcag actgggagtc ccccagagga   2280

aggaaggtgc ttcctctatc agactgggaa ctccctgagg gcaggagctg tctcctgcac   2340

tgaaacctca ccctgagcag cagctgtgcc ccttccatca gattctctat tcccccgatt   2400

taggagccat gcctcttcca tcaggctgaa agctcctcgg agcaggaagt ccatggggtc   2460

tctgctgaga ctggagcatg ctcttcccac cctcattctg ctcttggtgt ccttttgcag   2520

agcccgggcc cttctgccat gtgaacctct gtgcctgtga ccggaagctc gtctactgcc   2580

tcaagagaaa cctacggagc tacaacccac agtaccaata ctttcccaac atcctctgct   2640

cctaggcctc cccagcgagc tcctcccaga ccaagacttt tgttctgttt ttctacaaca   2700

cagagtactg actctgcctg gttcctgaga gaggctccta agtcacagac ctcagtcttt   2760

ctcgaagctt ggcggacccc cagggccaca ctgtaccctc cagcgagtcc caggagagtg   2820

actctggtca taggacttgg tagggtccca gggtccctag gcctccactt ctgagggcag   2880

cccctctggt gccaagagct ctcctccaac tcagggttgg ctgtgtctct tttcttctct   2940

gaagacagcg tcctggctcc agttggaaca ctttcctgag atgcacttac ttctcagctt   3000

ctgcgatcag attatcatca ccaccaccct ccagagaatt tttacgcaag aagagccaaa   3060

ttgactctct aaatctggtg tatgggtatt aaataaaatt cattctcaag gctaataaaa   3120

accacattgg cattttc                                                  3137


<210>  1558
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  1558

Met Ser Gly Val Phe Val Ala Lys Ser Ala Leu Val Val Gly Thr Val 
1               5                   10                  15


Ser Leu Gln Met Leu Pro Leu Leu Ser Leu Cys Leu Gln Gly Pro Gln 
            20                  25                  30


Trp Thr Tyr Ser Phe Leu Pro His Leu Phe Trp Leu Asp Ser Ser Cys 
        35                  40                  45


Leu Leu Pro Thr Met Thr Gly Ser Gly Ile Asp Gly Ala Trp Trp Arg 
    50                  55                  60


Ala Arg Val Gly Ser Glu Trp Ala Thr Gly Ala Leu Pro Asp Arg Ser 
65                  70                  75                  80


Val Val Gly Cys Val Phe Phe Ser Arg Thr Pro Glu Met Lys Gly Leu 
                85                  90                  95


Leu Pro Leu Ala Trp Phe Leu Ala Cys Ser Lys Cys Trp Pro Arg Asp 
            100                 105                 110


Leu Arg Met Asn Phe Tyr Pro Met Pro Gln Leu Cys Lys Gly Cys Gly 
        115                 120                 125


His Arg Gly Tyr Val Ala Gly Lys Cys Arg Arg Gln Ile Phe Ser Leu 
    130                 135                 140


Tyr Ala Asn Lys Ile Arg Phe Thr Lys Ser Pro Asn Gln Ser Lys 
145                 150                 155


<210>  1559
<211>  2626
<212>  DNA
<213>  Homo sapiens

<400>  1559
gggcagcctg catggaaagg gactgccagc atctgcctcc actgctctgt gctgggatca     60

tggaacttgc actgctgtgt gggctggtgg tgatggctgg tgtgattcca atccagggcg    120

ggatcctgaa cctgaacaag atggtcaagc aagtgactgg gaaaatgccc atcctctcct    180

actggcccta cggctgtcac tgcggactag gtggcagagg ccaacccaaa gatgccacgg    240

actggtgctg ccagacccat gactgctgct atgaccacct gaagacccag gggtgcagca    300

tctacaagga ctattacaga tacaactttt cccaggggaa catccactgc tctgacaagg    360

gaagctggtg tgagcagcag ctgtgtgcct gtgacaagga ggtggccttc tgcctgaagc    420

gcaacctgga cacctaccag aagcgactgc gtttctactg gcggccccac tgccgggggc    480

agacccctgg gtgctagaag cccacaccct ctaccctgtt cctcagcatg gagctctggc    540

atccccacct cagtatctaa cctgaaccag cctggctttt caaacactcc ggggggaggt    600

agtcccagcc tcccccggaa ccctctacca atgccttctg accttctgaa gctttccgaa    660

tcctcccagt tgaggcagta gctgtgtcct ctgagggtgg atgggaatct tgggagaagc    720

ccaagcaagg gagccctcag aggtggtgtt tggaccaaag catcggggtg ggggaggggt    780

ctgccgctgt cccccacctg ctggccccct tgtccttcct caccccctcc aatatagtct    840

cggagctaca accgcagcag ccactataaa gggcaatatt gatctttctg tccatgtggc    900

tctatctttt aaaacctcaa ggccctccac tgtcctaaga taaagcctct cataggcact    960

ggggaccctg cacagtctgg ccatgtgacc ctctccccag gcaagctctg aagtccctgc   1020

aggtggaggc catgcctgtc ttaaactcag ttgcatccct ggtgcccaaa gcaacaccag   1080

aaccaagaag gagctccata aatccttctt gggtgaagcc tagacaaagc cgccaggtct   1140

tgtggctcca ggcaccagag ccttgagtac tttctcctgc ctccaggcat tggctcaggg   1200

tgaattacaa ggggctactg aatggctatt actttcatca cgactgatcc ccacctcctc   1260

agggtcaaag ggctactttc tggaagtctc cccaggctga ctccttctcc ctgactgcaa   1320

gggctcactc cctcctccaa gctcccacaa tgcttcatgg ctctgccgct tacctagctt   1380

ggcctagagt ggcaaatgga acttctctga tctcccccaa ctagactgga gcccccgaag   1440

gatggagacc atgtctgtgc catctctgtt tcccctgttt tcccacatac taggtgctca   1500

attcatgcct gtgaatggcg tgagcccata atggatacac agaggttgca gcagatggtg   1560

tgggtacctc acccagatat catccaggcc caaggcccct ctccctgagt gaggccaggt   1620

gttggcagcc aactgctcca atctgcctcc ttcccctaaa tactgccctg gtctagtggg   1680

agctgccttc cccctgcccc acctctccca ccaagaggcc acctgtcact catggccagg   1740

agagtgacac catggagggt acaattgcca gctcccccgt gtctgtgcag gattgtctgg   1800

gttgaatgac actctcaaat tgttcctggg atcgggctga ggccaggcct ctcctggaac   1860

cacctctctg cttggtctga ccccttggcc tatccagttt tcctggttcc ctcacaggtt   1920

tctccagaaa gtactccctc agtaaagcat ttgcacaaga atccttgtct caggctctgc   1980

ttctaaggaa agagactgaa gagggacaac tttttcctat gaggactccc aatctgccat   2040

ttgtgtgtgg ctagctgttt ccagccaggg ggctgaggca cctgcagtca cccacactct   2100

gggcctgtgg caccatctgt gcctcagctg actgagcagt tctgagatgt ggtgactcat   2160

gtgaagtggt gtcataggaa tgaaggactg tgggcgctgg gttcaaattc cagttctatg   2220

caccactcca ggtagggata cccatggggg cagctgtgcc tgtgtggggg aacagggtag   2280

ggaaatctcc ataccttctc aattttgctg tgaacctaaa actgccatat aaagataaag   2340

tctaggccag gcatggtggc tcatgcctgt aatcccaaca cttagggtgg ctgaggcagg   2400

cagatcacct ggggtcagga gttcaagacc agcctgccca acatggcaaa acctcgtctc   2460

tactaaaaat acaaaaatta gccaggcatc gtggtgggtg cctgtaatcc cagctattca   2520

ggaggctgag gcaggagaat cacttggacc tgggaggcag aggtttcagt gagcccagat   2580

cgcgacactg cactccagcc tgggcaacag agtgacactc tgtctc                  2626


<210>  1560
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  1560

Met Glu Arg Asp Cys Gln His Leu Pro Pro Leu Leu Cys Ala Gly Ile 
1               5                   10                  15


Met Glu Leu Ala Leu Leu Cys Gly Leu Val Val Met Ala Gly Val Ile 
            20                  25                  30


Pro Ile Gln Gly Gly Ile Leu Asn Leu Asn Lys Met Val Lys Gln Val 
        35                  40                  45


Thr Gly Lys Met Pro Ile Leu Ser Tyr Trp Pro Tyr Gly Cys His Cys 
    50                  55                  60


Gly Leu Gly Gly Arg Gly Gln Pro Lys Asp Ala Thr Asp Trp Cys Cys 
65                  70                  75                  80


Gln Thr His Asp Cys Cys Tyr Asp His Leu Lys Thr Gln Gly Cys Ser 
                85                  90                  95


Ile Tyr Lys Asp Tyr Tyr Arg Tyr Asn Phe Ser Gln Gly Asn Ile His 
            100                 105                 110


Cys Ser Asp Lys Gly Ser Trp Cys Glu Gln Gln Leu Cys Ala Cys Asp 
        115                 120                 125


Lys Glu Val Ala Phe Cys Leu Lys Arg Asn Leu Asp Thr Tyr Gln Lys 
    130                 135                 140


Arg Leu Arg Phe Tyr Trp Arg Pro His Cys Arg Gly Gln Thr Pro Gly 
145                 150                 155                 160


Cys 



<210>  1561
<211>  443
<212>  DNA
<213>  Homo sapiens

<400>  1561
tgcccatcct ctcctactgg ccctacggct gtcactgcgg actaggtggc agaggccaac     60

ccaaagatgc cacggactgg tgctgccaga cccatgactg ctgctatgac cacctgaaga    120

cccaggggtg cagcatctac aaggactatt acagatacaa cttttcccag gggaacatcc    180

actgctctcc caccaagagg ccacctgtca ctcatggcca ggagagtgac accatggagg    240

gtacaattgc cagctccccc gtgtctgtgc aggattgtct gggttgaatg acactctcaa    300

attgttcctg ggatcgggct gaggccaggc ctctcctgga accacctctc tgcttggtct    360

gaccccttgg cctatccagt tttcctggtt ccctcacagg tttctccaga aagtactccc    420

tcagtaaagc atttgcacaa gaa                                            443


<210>  1562
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  1562

Pro Pro Glu Asp Pro Gly Val Gln His Leu Gln Gly Leu Leu Gln Ile 
1               5                   10                  15


Gln Leu Phe Pro Gly Glu His Pro Leu Leu Ser His Gln Glu Ala Thr 
            20                  25                  30


Cys His Ser Trp Pro Gly Glu 
        35


<210>  1563
<211>  1335
<212>  DNA
<213>  Homo sapiens

<400>  1563
actgccagca tctgcctcca ctgctctgtg ctgggatcat ggaacttgca ctgctgtgtg     60

ggctggtggt gatggctggt gtgattccaa tccagggcgg gatcctgaac ctgaacaaga    120

tggtcaagca agtgactggg aaaatgccca tcctctccta ctggccctac ggctgtcact    180

gcggactagg tggcagaggc caacccaaag atgccacgga ctgctgacaa gggaagctgg    240

tgtgagcagc agctgtgtgc ctgtgacaag gaggtggcct tctgcctgaa gcgcaacctg    300

gacacctacc agaagcgact gcgtttctac tggcggcccc actgccgggg gcagacccct    360

gggtgctaga agcccacacc ctctaccctg ttcctcagca tggagctctg gcatccccac    420

ctcagtatct aacctgaacc agcctggctt ttcaaacact ccggggggag gtagtcccag    480

cctcccccgg aaccctctac caatgccttc tgaccttctg aagctttccg aatcctccca    540

gttgaggcag tagctgtgtc ctctgagggt ggatgggaat cttgggagaa gcccaagcaa    600

gggagccctc agaggtggtg tttggaccaa agcatcgggg tgggggaggg gtctgccgct    660

gtcccccacc tgctggcccc cttgtccttc ctcaccccct ccaatatagt ctcggagcta    720

caaccgcagc agccactata aagggcaata ttgatctttc tgtccatgtg gctctatctt    780

ttaaaacctc aaggccctcc actgtcctaa gataaagcct ctcataggca ctggggaccc    840

tgcacagtct ggccatgtga ccctctcccc aggcaagctc tgaagtccct gcaggtggag    900

gccatgcctg tcttaaactc agttgcatcc ctggtgccca aagcaacacc agaaccaaga    960

aggagctcca taaatccttc ttgggtgaag cctagacaaa gccgccaggt cttgtggctc   1020

caggcaccag agccttgagt actttctcct gcctccaggc attggctcag ggtgaattac   1080

aaggggctac tgaatggcta ttactttcat cacgactgat ccccacctcc tcagggtcaa   1140

agggctactt tctggaagtc tccccaggct gactccttct ccctgactgc aagggctcac   1200

tccctcctcc aagctcccac aatgcttcat ggctctgccg cttacctagc ttggcctaga   1260

gtggcaaatg gaacttctct gatctccccc aactagactg gagcccccga aggatggaga   1320

ccatgtctgt gccat                                                    1335


<210>  1564
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  1564

Met Glu Leu Ala Leu Leu Cys Gly Leu Val Val Met Ala Gly Val Ile 
1               5                   10                  15


Pro Ile Gln Gly Gly Ile Leu Asn Leu Asn Lys Met Val Lys Gln Val 
            20                  25                  30


Thr Gly Lys Met Pro Ile Leu Ser Tyr Trp Pro Tyr Gly Cys His Cys 
        35                  40                  45


Gly Leu Gly Gly Arg Gly Gln Pro Lys Asp Ala Thr Asp Cys 
    50                  55                  60


<210>  1565
<211>  880
<212>  DNA
<213>  Homo sapiens

<400>  1565
gggcagcctg catggaaagg gactgccagc atctgcctcc actgctctgt gctgggatca     60

tggaacttgc actgctgtgt gggctggtgg tgatggctgg tgtgattcca atccagggcg    120

ggatcctgaa cctgaacaag atggtcaagc aagtgactgg gaaaatgccc atcctctcct    180

actggcccta cggctgtcac tgcggactag gtggcagagg ccaacccaaa gatgccacgg    240

actggtgctg ccagacccat gactgctgct atgaccacct gaagacccag gggtgcagca    300

tctacaagga ctattacaga tacaactttt cccaggggaa catccactgc tctgacaagg    360

gaagctggtg tgagcagcag ctgtgtgcct gtgacaagga ggtggccttc tgcctgaagc    420

gcaacctgga cacctaccag aagcgactgc gtttctactg gcggccccac tgccgggggc    480

agacccctgg gtgctagaag cccacaccct ctaccctgtt cctcagcatg gagctctggc    540

atccccacct cagtatctaa cctgaaccag cctggctttt caaacactcc ggggggaggt    600

agtcccagcc tcccccggaa ccctctacca atgccttctg accttctgaa gctttccgaa    660

tcctcccagt tgaggcagta gctgtgtcct ctgagggtgg atgggaatct tgggagaagc    720

ccaagcaagg gagccctcag aggtggtgtt tggaccaaag catcggggtg ggggaggggt    780

ctgccgctgt cccccacctg ctggccccct tgtccttcct caccccctcc aatatagtct    840

cggagctaca accgcagcag ccactataaa gggcaatatt                          880


<210>  1566
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  1566

Met Glu Arg Asp Cys Gln His Leu Pro Pro Leu Leu Cys Ala Gly Ile 
1               5                   10                  15


Met Glu Leu Ala Leu Leu Cys Gly Leu Val Val Met Ala Gly Val Ile 
            20                  25                  30


Pro Ile Gln Gly Gly Ile Leu Asn Leu Asn Lys Met Val Lys Gln Val 
        35                  40                  45


Thr Gly Lys Met Pro Ile Leu Ser Tyr Trp Pro Tyr Gly Cys His Cys 
    50                  55                  60


Gly Leu Gly Gly Arg Gly Gln Pro Lys Asp Ala Thr Asp Trp Cys Cys 
65                  70                  75                  80


Gln Thr His Asp Cys Cys Tyr Asp His Leu Lys Thr Gln Gly Cys Ser 
                85                  90                  95


Ile Tyr Lys Asp Tyr Tyr Arg Tyr Asn Phe Ser Gln Gly Asn Ile His 
            100                 105                 110


Cys Ser Asp Lys Gly Ser Trp Cys Glu Gln Gln Leu Cys Ala Cys Asp 
        115                 120                 125


Lys Glu Val Ala Phe Cys Leu Lys Arg Asn Leu Asp Thr Tyr Gln Lys 
    130                 135                 140


Arg Leu Arg Phe Tyr Trp Arg Pro His Cys Arg Gly Gln Thr Pro Gly 
145                 150                 155                 160


Cys 



<210>  1567
<211>  2723
<212>  DNA
<213>  Homo sapiens

<400>  1567
agtgtgcgag gcagcgtgaa gctggggcct gctccccgca gcctctggag cgcatctcag     60

accttctgag acctatgttg ctggcccccc agaacccgca acatggcaga tggggcaaag    120

gccaacccca aagggttcaa aaagaaggtg ctggatagat gcttctctgg gtggaggggc    180

ccacgcttcg gggcctcctg tccttcaaga acctccaggt ctagcctggg tatgaagaag    240

ttcttcaccg tggccatcct tgctggcagc gttctgtcca cagctcacgg cagcctgctc    300

aacctgaagg ccatggtgga ggccgtcaca gggaggagcg ccatcctgtc cttcgtgggc    360

tacggttgct actgtgggct ggggggccgt ggccagccca aggatgaggt ggactggtgc    420

tgccacgccc acgactgctg ctaccaggaa ctctttgacc aaggctgtca cccctatgtg    480

gaccactatg atcacaccat cgagaacaac actgagatag tctgcagtga cctcaacaag    540

acagagtgtg acaagcagac atgcatgtgt gacaagaaca tggttctgtg cctcatgaac    600

cagacgtacc gagaggagta ccgtggcttc ctcaatgtct actgccaggg ccccacgccc    660

aactgcagca tctatgaacc gccccctgag gaggtcacct gcagtcacca atccccagcg    720

ccccccgccc ctccctagag cctctgaggt ttgagagaga gagcgggagg agggtctggc    780

ttggggacca gacgaggtgc agggagggta ggagccaggc caggagcctg agggttgctg    840

gttgcctcct ccctggagct ctccagtgag ggctcagctc tcagaggact caggaaggcc    900

tgggtcctga ctcccccagc ccagccccag gcatgggtgc ctcctgctgc tggttctgga    960

ctgggtggga ggcacggagc ttataggggt ctctcctgag ggtggccggg gagacctgag   1020

agagaggagg aggggcctct gagtggggcc tctgttgctg gcgccagttt aactccccgg   1080

agccttagaa agtctgagcc ttagaaagtc tgggcctgag catccaggcc cagagctgga   1140

tgcatcctcg gcccaagatc acaggaaggc agattgctgg tcacaaagca tgggttccgg   1200

gagcccctca gctgatccca caggatggcc tggggtggtg gctactttgg gcttgaagct   1260

ctctagagcc ccattcacag agcaggtgcc ccaccccagc cctcactgag gtggccatga   1320

gtccaggttc agaccctagg ggatgtgcag tgctgagtgt cccagccctg aagtctagcc   1380

tcagagcagg ctcctgggca ctgacagagc cacacaccca ggtacacccc ccaggctaat   1440

atggggacac acaaaaatat ggccttcaac acctacaagt cttctctgtg tcccccatcg   1500

acccatgcac atcaccccaa ccctgctctg ccacaccacg tgggtctgag gagcactcct   1560

accccccggc tccgggtccc tgacagacac tgccctcctg gcctgcacct ggaatggcag   1620

ccagaacact ggagggggac ccacaccctc tctccctggg ctgtggatgg gtgttgcaag   1680

tcccatccct cctggcctgc acctggaaca gcagccagaa caccggaggg ggacccacac   1740

cctctctccc tgggctgtgg gcaggcgtca caagtcccat tggtggggaa gaggctgagg   1800

gctgagaccc acctcagtga agagggaaac gtaagcaggg agagcatcaa ggcgggaggc   1860

agcctggaaa cttctagaag agggtcaagg taggaggcta catggaagct tctagaaggc   1920

agtaaggaac agggtggtga aggagagggg agaagatggg agcatggaga gacgaggtga   1980

gtgacagcca ccagcaggga cgggcctcca ggcaacacag aggagctggg ggccagggcc   2040

ttacggggct gggttcctgt gtggggcgtg gagctggggc tgaagtggag gggacggccc   2100

tgcggccccc agcactgttg tttctccagg tgcaccttac cttcctcctt acctgcccga   2160

gcctcaactc agggtcagca gcctccacgg agccagcccc acctgcccga aaaccactga   2220

agccaccctc cgcccggact caacagccgc cagcaagctc gcctggcagt gcccctggag   2280

caccattgtc gctggggagg gagagccggg aagggtggag aaggaggcag aagggacatg   2340

tatgaaaaaa ggacaggaaa cctgaccaga ggcggtttcc agagccccag ccttggagac   2400

aaggacactg ccacccagcg ccacagtcag tctgggaggg gcccacgccc cccacccccc   2460

atgccacact gccgcctctt gctggccatg gttctccggc ttgggggaac gcaggttccc   2520

agctgcgccc ctcccccgcg cacacacacc ctcccctgtc cctcggaaag actaggccag   2580

ggtctgggga tgggattctg ctgccagggg tcctgcctgc ccccactcac cccagacgct   2640

tcggatgctg cagctcctgg ataatctcca caggactcgg cttcctctcc tcaaatgaat   2700

aaaggcctcc tacctcaact ccc                                           2723


<210>  1568
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  1568

Met Ala Asp Gly Ala Lys Ala Asn Pro Lys Gly Phe Lys Lys Lys Val 
1               5                   10                  15


Leu Asp Arg Cys Phe Ser Gly Trp Arg Gly Pro Arg Phe Gly Ala Ser 
            20                  25                  30


Cys Pro Ser Arg Thr Ser Arg Ser Ser Leu Gly Met Lys Lys Phe Phe 
        35                  40                  45


Thr Val Ala Ile Leu Ala Gly Ser Val Leu Ser Thr Ala His Gly Ser 
    50                  55                  60


Leu Leu Asn Leu Lys Ala Met Val Glu Ala Val Thr Gly Arg Ser Ala 
65                  70                  75                  80


Ile Leu Ser Phe Val Gly Tyr Gly Cys Tyr Cys Gly Leu Gly Gly Arg 
                85                  90                  95


Gly Gln Pro Lys Asp Glu Val Asp Trp Cys Cys His Ala His Asp Cys 
            100                 105                 110


Cys Tyr Gln Glu Leu Phe Asp Gln Gly Cys His Pro Tyr Val Asp His 
        115                 120                 125


Tyr Asp His Thr Ile Glu Asn Asn Thr Glu Ile Val Cys Ser Asp Leu 
    130                 135                 140


Asn Lys Thr Glu Cys Asp Lys Gln Thr Cys Met Cys Asp Lys Asn Met 
145                 150                 155                 160


Val Leu Cys Leu Met Asn Gln Thr Tyr Arg Glu Glu Tyr Arg Gly Phe 
                165                 170                 175


Leu Asn Val Tyr Cys Gln Gly Pro Thr Pro Asn Cys Ser Ile Tyr Glu 
            180                 185                 190


Pro Pro Pro Glu Glu Val Thr Cys Ser His Gln Ser Pro Ala Pro Pro 
        195                 200                 205


Ala Pro Pro 
    210


<210>  1569
<211>  4094
<212>  DNA
<213>  Homo sapiens

<400>  1569
tgcgaggcag cgtgaagctg gggcctgctc cccgcagcct ctggagcgca tctcagacct     60

tctgagacct atgttgctgg ccccccagaa cccgcaacat ggcagatggg gcaaaggcca    120

accccaaagg gttcaaaaag aaggtgctgg atagatgctt ctctgggtgg aggggcccac    180

gcttcggggc ctcctgtcct tcaagaacct ccaggtctag cctgggtatg aagaagttct    240

tcaccgtggc catccttgct ggcagcggtg agtaaagact ccagagggct cctccttctc    300

tcccactccc agcttgtctc ccgtgacctt gggcgcctga gttatggttc cactgaccag    360

cctaggttcc ttcctgtctc tgggcttctg cttcttgtct cagcccagca ggctgcaccc    420

aattctgggg ctgtttaccc ctccagccac ctgtaaacat gcatttatga gccctggggg    480

gcagggcgca gggctgagca agcatcgtaa aatgctggtg ttggctgggc atttgtgtac    540

ctgaatgtgt actagtgtgt gtccatcaga ctggagttaa tgattttgtg tgcagacagg    600

cacaggcatc tatgtgtgtg taggtgtgtc tgagcatgtg atgatgtcta tgtgtgcaac    660

atgcatccat aaagtatgtg acagtgtagg cacctgagtg cgagcccatt tgtgtctctt    720

tgtgtgagtg tgtgttaatt ggggtgtgtg tcttcagagc atgcttatgg atgaagggtg    780

catagatctg caggagggtg tgtgtgtgta ggatgggtgt ctgtgtactg catagtggtg    840

ggaggtcagg ggcttctttc tggggttggt acccagggca tcatggctct gggcagccgc    900

cccataggat tgttgcgtga ggctcttgac acagacctga ccctgccact cgtcccggca    960

tcatttatgt ggcaggtgtc ccagctccat ggaccattgg ctgggcctct cactggcctt   1020

gcatgcagcc tgttaaacct cgccagaaca cagcctggct tgaggaaaag aaataaatga   1080

caaaaaccaa aataaggttc cacgtggcca gacgtgagag agggctggtt gcattcaggc   1140

aaagtgactt gttattgaga agacgactgc ttgagttcag tccaagccac tggttagggg   1200

cagagccttc aacccaactg aatgcggact tggattcctt cgcttggacg gtcagtgtgg   1260

atgtggcctt gggccaggcc cctgattctc ccctggatgc gttgtgtatg tgagtgcatc   1320

tgtaatgcac gagggcgagt gtgcaagtgt gtgtatcagg tatgtgtgta tgagtgtatc   1380

aggtatgtat gtgtgagtgt tgagtgtatc aggtatgtgg gggtgagtgt gagtttgagg   1440

tgtctgggaa tgagtgtgta tgcaagtgca tgtggtgtgt aaaggagagt gtgaggtggg   1500

caggtgtgtg agtgtgtgtg agatgggtgt gtgtgtgtca gtgtgtgttc accctgtgca   1560

tggccacgta gacttcttgc tcttcttctc ttgccacatg ggagttgact gtcgggggtc   1620

ctgggactgg aggtgccccc tcccgggtaa cacttacaag gccaggggca gatggggagg   1680

cagccagggc ctcgcagtgg ttgggtccct cctcaaggcg ctgtgtgggc caggcactct   1740

acacaccttc atgatcacac ttcaacctcc aaggtgccct gcaaggaggc gtcatgatct   1800

ccatcctctg ctttgggcat tgtgatccga gaggttgctg gtgtgtgcca ggcctccagc   1860

agggcactgg cctgcctgat ctctcatggt ttagattgtt actcccattt tacagatggg   1920

agaacagagc cccagggagt cccagctggg cttggttatt ggcctaggtc tgtctgactc   1980

cagattcaat gctcttccca ctaaggcaca ttgaggtggt gagttccctg tcattagaga   2040

tgtcggacac catgtctctg gaagcaggca agagtggcct ttgggattcc cctgagccac   2100

cagtttctga aaccgttggc tttcccctct cccagtacat ttcctcattc aggctgggga   2160

gcagggtgga catggagaga gtggcaggaa gggtgctgag ctaggcccct cacgctgact   2220

gcagctagaa tggctggggt gggggaagca ggcggagctg cactgccctg cgctgcggtt   2280

agcttcccag ctccgcagta cacaaacctg gggcagtctg ggctctgccc cctccagcct   2340

gtgggacctg ggcaagcctg cacctttctg agccttagtt tcctcaccca taaaatcgtg   2400

atagattggc tctcctgctg gtgtgtgtag ggcagcttcc cccaggtaag gactgtaggt   2460

gccaggctgg gcgtgtggac ccagtgctgc atccaggagg atgtgcagag gcagcgcagg   2520

caattcagag agccaccgca caggcacaga ctgcaagatg gagacaagca gtggccaggg   2580

ggagaatgtg tcctggggtg ggccggcctg gcaggtgcca tgaagctgat ttcgctggtg   2640

caggaagtgt ccttgcacta tttctccctc tgtgtgtgtg tggggagact gttttccttc   2700

ttcccacctc cagccagtat cagcctgtaa tacgaagcct tttctgtttc ttcattagcg   2760

atcagagcac cgaattgtcg ctggattgat cctgagatgc accaggcccg ggatcagggt   2820

ggggactctg aggcccccag gagggcagag gcaggaggca gagaccagga agggacccag   2880

aatcaacccc ctgagcttcc taagagcatg tggcctttgc gaagctccct ccagcatacc   2940

aggcacttgg gcatccccct tgagaagtgt gtacagccaa gtggcagggg gtgtggatgc   3000

aaaaccctca ctgcctgggt ccaaattctg tctccactgc tttctgacaa cgggatgtag   3060

agcaagttac taaatgcact gggcctcagt cttctcatct gcacagaggc ataacaagag   3120

catgcagggg gttgcagtga gcactcaatg gattcatgca catggaaggg gcttgggaca   3180

gtacctggca tggagcaagt ccctagcaag gatgacctgc gttgttttct cagggccgca   3240

gggatgtggg tgcacaccat acatggtacc ttgcagattt ctttcctctg gcttagctgc   3300

ccacgcttct tgccccagct tcctctcctg ctttctcctt ccttctccca cctaccctag   3360

gtattgggag gatggtcagt ccagactctc aggatgagag aggctgggag cggccagccc   3420

cggggcaggg gctcagagca ccccctggtt ctcttgcagt tctgtccaca gctcacggca   3480

gcctgctcaa cctgaaggcc atggtggagg ccgtcacagg gaggagcgcc atcctgtcct   3540

tcgtgggcta cggttgctac tgtgggctgg ggggccgtgg ccagcccaag gatgaggtgg   3600

actggtaggt accagaggcc tgggctcctg tcaggggcca aatgaggaca gctgaaggtc   3660

agactgacct tgccctccat ccctgagtgg gggagacctt ctttccccaa aggatccagc   3720

ttctttgatg acttggtgac cagagcctgg tctttgacta tgttctttcc aaactgtttt   3780

gagcgctttc tgttgtccat ctccaaggcc atgggcttgg aagtgtttca gcccctcctc   3840

tctctaggaa gggacctttg acttgctcca aaacacacat gggagagcag tcacacagct   3900

gacaccccac aaaggcaagg gctgtgaccc ctgcctgcct cacactggag gctctggaag   3960

acaggaccat gcctcctcca tcagactgtg agctcccagc agccatggct tgtcttctgc   4020

tcctatctcc ccaacagcag gcagcaccaa gtttgtatca cagaaagcta aataaataca   4080

cattgactag ctga                                                     4094


<210>  1570
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  1570

Met Arg Thr Trp Ile Pro Ser Leu Gly Arg Ser Val Trp Met Trp Pro 
1               5                   10                  15


Trp Ala Arg Pro Leu Ile Leu Pro Trp Met Arg Cys Val Cys Glu Cys 
            20                  25                  30


Ile Cys Asn Ala Arg Gly Arg Val Cys Lys Cys Val Tyr Gln Val Cys 
        35                  40                  45


Val Tyr Glu Cys Ile Arg Tyr Val Cys Val Ser Val Glu Cys Ile Arg 
    50                  55                  60


Tyr Val Gly Val Ser Val Ser Leu Arg Cys Leu Gly Met Ser Val Tyr 
65                  70                  75                  80


Ala Ser Ala Cys Gly Val 
                85


<210>  1571
<211>  1081
<212>  DNA
<213>  Homo sapiens

<400>  1571
ccgggaaatc gggtgactga tggacggtgg aggcagcccc ttaggcagtt taggcctgcc     60

ctgtgaagta tccctgtggg cggctctggc cagcttgagt gacgcagatc ctgagagcgc    120

tcctggttca ccctttctcc ccaggtgatc gggtatggat cacggattgg aacatagcct    180

ccttgcagcc acggtggaga ggaccccaga ccatcgtctt gaccactccc acagccataa    240

aggtagaagg aatcccagcc tggattcacc acagccatgt aaaacctaaa gcatctgaga    300

cctgggaggt gagaccaagc ttggacaacc catgcaagat gactttgaag aagatgacaa    360

gccctgctcc agtcacacct ggaagctgac tggtccgtgc atggctgaag catgaggaaa    420

ctcatcgtgg gactcatttt cctaaaattt tggacttgta cagtaaggac ttcaactgac    480

cttcctcaga ctgaggtagg gcaaaaagtt aaaacagact ttctgtttaa aagggacttg    540

tgtgtataat gctacccagt acaagatatg cagcccaaga agtgaccagc ttgatgtgtg    600

ctataaccca ttggaactag tttatccctg ttggaaaaca gagtatgtaa ctctaggaat    660

tgatggaact ggactggaag acctgggtag tgaagatgac agtgagaact cccactagtg    720

agtgagattc tcaaaggggg gaatgagaag tgaggccatt tctcttactg tctcctgtct    780

ctgaagagga ggaggaagta aaagttgaaa aacaacagga atgaagtcat tggcaagacc    840

agccggtgcc actgatgacc aggcctgagg ttaaaagatc aaccccccac tctaaccaca    900

tgtgctctca atctatcatg accctttcat gtggaccccc ttagagttgt aagcccttaa    960

aagggccagg aactctgtct tcagggagct cggttcttga gacatgagtc tgccaaagct   1020

cccagctgtt gagatgcgag tctgccaaag ctcctggccg aataaagcca aatccttcct   1080

t                                                                   1081


<210>  1572
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  1572

Met Asp Gly Gly Gly Ser Pro Leu Gly Ser Leu Gly Leu Pro Cys Glu 
1               5                   10                  15


Val Ser Leu Trp Ala Ala Leu Ala Ser Leu Ser Asp Ala Asp Pro Glu 
            20                  25                  30


Ser Ala Pro Gly Ser Pro Phe Leu Pro Arg 
        35                  40


<210>  1573
<211>  3446
<212>  DNA
<213>  Homo sapiens

<400>  1573
gtgtcggtgc gcggtgctcc gtggctgcgc tgctggaacc cgctggaaga gatacaggtt     60

tgctctggag cagcagcagc tggcggagca atggagatgc aatcctatta tgccaagctt    120

ttgggggagc tgaatgaaca gagaaagagg gactttttct gtgactgcag catcattgtg    180

gaagggcgga tcttcaaggc ccacaggaac attttgtttg ctaacagcgg ctacttccga    240

gccctgctca ttcactatat ccaggacagc gggcggcata gcaccgcctc cttggacatt    300

gtcacctctg atgccttctc catcatctta gatttcctct attctgggaa gttggatttg    360

tgtggggaga atgtgattga agtgatgtcg gctgccagct acctgcagat gaatgacgtg    420

gtgaacttct gcaagacata cattaggtca tccctcgaca tttgccgaaa gatggagaag    480

gaggctgctg tggctgcagc agtggcggcg gcagcggcgg cggctgcagc ggcggcagca    540

gcggcggctc atcaggttga cagtgaaagc cccagttcag gccgggaggg gacctcctgt    600

ggtaccaaga gcttggtctc ctctccagcc gagggagaaa agagcgtgga gtgcctgaga    660

gagtcccctt gcggtgactg cggagactgc caccccttgg aactggtggt gagagacagc    720

cttggcggtg gctcggctga cagcaacctc tctactccac ccaaacggat agagcccaag    780

gtggaatttg atgctgatga agtggaggtg gacgttggtg aacagctgca gcagtatgct    840

gccccgctga acctggccca cgtggaggag gccttgccaa gcggccaggc ggttgacttg    900

gcttacagca actaccacgt gaagcagttc ctggaggcgc tcttgcgcaa cagcgctgcc    960

ccgagcaagg atgatgcaga ccatcacttt tctaggagtt tggaaggaag accagaaggt   1020

gcaggagtag ccatgagttc catgatggat gtccaggctg actggtatgg agaggactca   1080

ggtgatgtgc tggtggtccc catcaagctc cacaagtgtc ctttctgccc ttacactgcc   1140

aaacagaagg gcatcctcaa gcggcacatc cgttcacaca caggcgagcg gccctacccc   1200

tgtgagacct gcggcaagag gttcactcga caagagcacc tgcggagcca cgcactgagt   1260

gtccacagat ccaaccgtcc aatcatctgc aagggctgca ggagaacatt cacgagtcac   1320

ctgtcccagg ggctgcggcg cttcgggctg tgtgacagct gcacctgcgt tacagacaca   1380

cccgatgatg atgatgattt gatgcccatc aaccttagct tggtggaggc ttcatctgaa   1440

agccaagaaa agagcgacac agacaatgac tggccaatct atgtggagtc ggagatcggg   1500

tctcattatg ttgcccaggc tagtctggaa ctcctggcct taagccaacc tcctgcctca   1560

gcctcccaaa gtgctggcat tacagacgga gtctcactct gttgcccagg ccggagtaca   1620

gtggcatgat ctcagctctc tgcaacctcc acctcctggg ttcaagacaa tcctccaaac   1680

acagactgtt tgacttagaa tcttcccttt tttactccat tcaagagcag cattcataaa   1740

tttccagaat ggagatctcc tctcatcagt ctcacctcct gcagcaactg aacgagcagc   1800

gcaggcaaga tgtattttgt gactgcagta ttctagttga agggaaggtc ttcaaagcac   1860

atcgaaatgt attattcgct agtagcggct actttaaaat gcttctttct cagaattcaa   1920

aggagacgag tcagccaacc acagctacat ttcaggcttt ctcccctgac acttttacag   1980

ttatcttgga cttcgtatat tctggcaaac tgtctcttac tggtcagaat gtcatagaag   2040

tgatgtcggc tgctagcttc cttcagatga ctgatgtcat aagtgtatgt aagactttta   2100

ttaaatcttc cttagacatt agtgagaaag aaaaagatcg ctatttcagt ctctcagata   2160

aagatgccaa ttctaatggt gtagaacgtt cctcttttta tagtggtggc tggcaagaag   2220

gaagcagttc tccacgttct cacctaagcc cagagcaagg aacaggtata ataagtggaa   2280

aatcttggaa taagtataat tatcatccag cctcccagaa gaatactcaa caacccttgg   2340

ccaagcatga accaaggaaa gagtccatta aaaagaccaa acatttgaga ttgtcacagc   2400

cttctgaagt tactcattat aagtcaagca aacgagaagt acgaacatct gattcttcca   2460

gccatgtttc ccagtctgaa gaacaagcac agattgatgc tgaaatggac tctactcctg   2520

ttggctatca gtacggtcaa ggatctgatg tcacatccaa aagctttcca gatgatctgc   2580

ctcggatgcg attcaagtgc ccgtactgca cacatgtggt gaagcggaag gcagacctaa   2640

agcgccacct tcgttgtcat acaggagaaa ggccctatcc atgtcaagct tgtggaaaaa   2700

gatttagcag gctagaccat ctaagtagcc attttcgaac aattcaccag gcatgtaaac   2760

tcatctgcag aaaatgtaaa cgtcatgtga cagatctaac agggcaagtg gtacaggagg   2820

gaaccaggcg ctacagactg tgtaatgagt gtcttgcaga atttggcata gacagcctcc   2880

ccattgactt ggaagctgaa caacatctta tgtccccatc agatggagat aaggattcca   2940

gatggcactt gagtgaagat gagaatagat cctatgtgga gattgtagaa gatgggtctg   3000

gtgatctggt catccaacag gttgatgata gtgaagaaga agaagaaaaa gaaattaagc   3060

ccaacattag gtagctgtaa tgtgaaccaa cagagctggc atgtctgcaa tttacattga   3120

cttcctgtat ctctctcttt ctatggtcgg agtctagtta acaaatttat cacactgact   3180

ttaaagaaat gatctgatat aacttgcatg ctttctgaac aggccattgt atccattctg   3240

aactttgttg ccctaaaatg tgttgctgca ctggaaagaa agaactagct tgagttggct   3300

tgatggatga acaattatcc tcttactttc attacaatcc tcttacttta ttccagagat   3360

acctttttct tttaatattg gaggatctac ttagcaaact tttttcaaag aaaatacttt   3420

aaataaattc accacaacca aacttt                                        3446


<210>  1574
<211>  512
<212>  PRT
<213>  Homo sapiens

<400>  1574

Met Glu Met Gln Ser Tyr Tyr Ala Lys Leu Leu Gly Glu Leu Asn Glu 
1               5                   10                  15


Gln Arg Lys Arg Asp Phe Phe Cys Asp Cys Ser Ile Ile Val Glu Gly 
            20                  25                  30


Arg Ile Phe Lys Ala His Arg Asn Ile Leu Phe Ala Asn Ser Gly Tyr 
        35                  40                  45


Phe Arg Ala Leu Leu Ile His Tyr Ile Gln Asp Ser Gly Arg His Ser 
    50                  55                  60


Thr Ala Ser Leu Asp Ile Val Thr Ser Asp Ala Phe Ser Ile Ile Leu 
65                  70                  75                  80


Asp Phe Leu Tyr Ser Gly Lys Leu Asp Leu Cys Gly Glu Asn Val Ile 
                85                  90                  95


Glu Val Met Ser Ala Ala Ser Tyr Leu Gln Met Asn Asp Val Val Asn 
            100                 105                 110


Phe Cys Lys Thr Tyr Ile Arg Ser Ser Leu Asp Ile Cys Arg Lys Met 
        115                 120                 125


Glu Lys Glu Ala Ala Val Ala Ala Ala Val Ala Ala Ala Ala Ala Ala 
    130                 135                 140


Ala Ala Ala Ala Ala Ala Ala Ala Ala His Gln Val Asp Ser Glu Ser 
145                 150                 155                 160


Pro Ser Ser Gly Arg Glu Gly Thr Ser Cys Gly Thr Lys Ser Leu Val 
                165                 170                 175


Ser Ser Pro Ala Glu Gly Glu Lys Ser Val Glu Cys Leu Arg Glu Ser 
            180                 185                 190


Pro Cys Gly Asp Cys Gly Asp Cys His Pro Leu Glu Leu Val Val Arg 
        195                 200                 205


Asp Ser Leu Gly Gly Gly Ser Ala Asp Ser Asn Leu Ser Thr Pro Pro 
    210                 215                 220


Lys Arg Ile Glu Pro Lys Val Glu Phe Asp Ala Asp Glu Val Glu Val 
225                 230                 235                 240


Asp Val Gly Glu Gln Leu Gln Gln Tyr Ala Ala Pro Leu Asn Leu Ala 
                245                 250                 255


His Val Glu Glu Ala Leu Pro Ser Gly Gln Ala Val Asp Leu Ala Tyr 
            260                 265                 270


Ser Asn Tyr His Val Lys Gln Phe Leu Glu Ala Leu Leu Arg Asn Ser 
        275                 280                 285


Ala Ala Pro Ser Lys Asp Asp Ala Asp His His Phe Ser Arg Ser Leu 
    290                 295                 300


Glu Gly Arg Pro Glu Gly Ala Gly Val Ala Met Ser Ser Met Met Asp 
305                 310                 315                 320


Val Gln Ala Asp Trp Tyr Gly Glu Asp Ser Gly Asp Val Leu Val Val 
                325                 330                 335


Pro Ile Lys Leu His Lys Cys Pro Phe Cys Pro Tyr Thr Ala Lys Gln 
            340                 345                 350


Lys Gly Ile Leu Lys Arg His Ile Arg Ser His Thr Gly Glu Arg Pro 
        355                 360                 365


Tyr Pro Cys Glu Thr Cys Gly Lys Arg Phe Thr Arg Gln Glu His Leu 
    370                 375                 380


Arg Ser His Ala Leu Ser Val His Arg Ser Asn Arg Pro Ile Ile Cys 
385                 390                 395                 400


Lys Gly Cys Arg Arg Thr Phe Thr Ser His Leu Ser Gln Gly Leu Arg 
                405                 410                 415


Arg Phe Gly Leu Cys Asp Ser Cys Thr Cys Val Thr Asp Thr Pro Asp 
            420                 425                 430


Asp Asp Asp Asp Leu Met Pro Ile Asn Leu Ser Leu Val Glu Ala Ser 
        435                 440                 445


Ser Glu Ser Gln Glu Lys Ser Asp Thr Asp Asn Asp Trp Pro Ile Tyr 
    450                 455                 460


Val Glu Ser Glu Ile Gly Ser His Tyr Val Ala Gln Ala Ser Leu Glu 
465                 470                 475                 480


Leu Leu Ala Leu Ser Gln Pro Pro Ala Ser Ala Ser Gln Ser Ala Gly 
                485                 490                 495


Ile Thr Asp Gly Val Ser Leu Cys Cys Pro Gly Arg Ser Thr Val Ala 
            500                 505                 510


<210>  1575
<211>  3966
<212>  DNA
<213>  Homo sapiens

<400>  1575
gtgtcggtgc gcggtgctcc gtggctgcgc tgctggaacc cgctggaaga gatacaggtt     60

tgctctggag cagcagcagc tggcggagca atggagatgc aatcctatta tgccaagctt    120

ttgggggagc tgaatgaaca gagaaagagg gactttttct gtgactgcag catcattgtg    180

gaagggcgga tcttcaaggc ccacaggaac attttgtttg ctaacagcgg ctacttccga    240

gccctgctca ttcactatat ccaggacagc gggcggcata gcaccgcctc cttggacatt    300

gtcacctctg atgccttctc catcatctta gatttcctct attctgggaa gttggatttg    360

tgtggggaga atgtgattga agtgatgtcg gctgccagct acctgcagat gaatgacgtg    420

gtgaacttct gcaagacata cattaggtca tccctcgaca tttgccgaaa gatggagaag    480

gaggctgctg tggctgcagc agtggcggcg gcagcggcgg cggctgcagc ggcggcagca    540

gcggcggctc atcaggttga cagtgaaagc cccagttcag gccgggaggg gacctcctgt    600

ggtaccaaga gcttggtctc ctctccagcc gagggagaaa agagcgtgga gtgcctgaga    660

gagtcccctt gcggtgactg cggagactgc caccccttgg aactggtggt gagagacagc    720

cttggcggtg gctcggctga cagcaacctc tctactccac ccaaacggat agagcccaag    780

gtggaatttg atgctgatga agtggaggtg gacgttggtg aacagctgca gcagtatgct    840

gccccgctga acctggccca cgtggaggag gccttgccaa gcggccaggc ggttgacttg    900

gcttacagca actaccacgt gaagcagttc ctggaggcgc tcttgcgcaa cagcgctgcc    960

ccgagcaagg atgatgcaga ccatcacttt tctaggagtt tggaaggaag accagaaggt   1020

gcaggagtag ccatgagttc catgatggat gtccaggctg actggtatgg agaggactca   1080

ggtgatgtgc tggtggtccc catcaagctc cacaagtgtc ctttctgccc ttacactgcc   1140

aaacagaagg gcatcctcaa gcggcacatc cgttcacaca caggcgagcg gccctacccc   1200

tgtgagacct gcggcaagag gttcactcga caagagcacc tgcggagcca cgcactgagt   1260

gtccacagat ccaaccgtcc aatcatctgc aagggctgca ggagaacatt cacgagtcac   1320

ctgtcccagg ggctgcggcg cttcgggctg tgtgacagct gcacctgcgt tacagacaca   1380

cccgatgatg atgatgattt gatgcccatc aaccttagct tggtggaggc ttcatctgaa   1440

agccaagaaa agagcgacac agacaatgac tggccaatct atgtggagtc ggagatcggg   1500

tctcattatg ttgcccaggc tagtctggaa ctcctggcct taagccaacc tcctgcctca   1560

gcctcccaaa gtgctggcat tacagacgga gtctcactct gttgcccagg ccggagtaca   1620

gtggcatgat ctcagctctc tgcaacctcc acctcctggg ttcaagacaa tcctccaaac   1680

acagactgtt tgacttagaa tcttcccttt tttactccat tcaagagcag cattcataaa   1740

tttccagaat ggagatctcc tctcatcagt ctcacctcct gcagcaactg aacgagcagc   1800

gcaggcaaga tgtattttgt gactgcagta ttctagttga agggaaggtc ttcaaagcac   1860

atcgaaatgt attattcgct agtagcggct actttaaaat gcttctttct cagaattcaa   1920

aggagacgag tcagccaacc acagctacat ttcaggcttt ctcccctgac acttttacag   1980

ttatcttgga cttcgtatat tctggcaaac tgtctcttac tggtcagaat gtcatagaag   2040

tgatgtcggc tgctagcttc cttcagatga ctgatgtcat aagtgtatgt aagactttta   2100

ttaaatcttc cttagacatt agtgagaaag aaaaagatcg ctatttcagt ctctcagata   2160

aagatgccaa ttctaatggt gtagaacgtt cctcttttta tagtggtggc tggcaagaag   2220

gaagcagttc tccacgttct cacctaagcc cagagcaagg aacaggtata ataagtggaa   2280

aatcttggaa taagtataat tatcatccag cctcccagaa gaatactcaa caacccttgg   2340

ccaagcatga accaaggaaa gagtccatta aaaagaccaa acatttgaga ttgtcacagc   2400

cttctgaagt tactcattat aagtcaagca aacgagaagt acgaacatct gattcttcca   2460

gccatgtttc ccagtctgaa gaacaagcac agattgatgc tgaaatggac tctactcctg   2520

ttggctatca gtacggtcaa ggatctgatg tcacatccaa aagctttcca gatgatctgc   2580

ctcggatgcg attcaagtgc ccgtactgca cacatgtggt gaagcggaag gcagacctaa   2640

agcgccacct tcgttgtcat acaggagaaa ggccctatcc atgtcaagct tgtggaaaaa   2700

gatttagcag gctagaccat ctaagtagcc attttcgaac aattcaccag gcatgtaaac   2760

tcatctgcag aaaatgtaaa cgtcatgtga cagatctaac agggcaagtg gtacaggagg   2820

gaaccaggcg ctacagactg tgtaatgagt gtcttgcaga atttggcata gacagcctcc   2880

ccattgactt ggaagctgaa caacatctta tgtccccatc agatggagat aaggattcca   2940

gatggcactt gagtgaagat gagaatagat cctatgtgga gattgtagaa gatgggtctg   3000

gtgatctggt catccaacag gttgatgata gtgaagaaga agaagaaaaa gaaattaagc   3060

ccaacattag gtagctgtaa tgtgaaccaa cagagctggc atgtctgcaa tttacattga   3120

cttcctgtat ctctctcttt ctatggtcgg agtctagtta acaaatttat cacactgact   3180

ttaaagaaat gatctgatat aacttgcatg ctttctgaac aggccattgt atccattctg   3240

aactttgttg ccctaaaatg tgttgctgca ctggaaagaa agaactagct tgagttggct   3300

tgatggatga acaattatcc tcttactttc attacaatcc tcttacttta ttccagagat   3360

acctttttct tttaatattg gaggatctac ttagcaaact tttttcaaag aaaatacttt   3420

aaataaattc accacaacca aactttatgt aagacaattt caaggtgttt caaaaacaca   3480

taactaccaa tgtttaattt cacagggaac cagttaagag cacatttaag gatctggcaa   3540

cccaccttac taaacaaatt agtctttcta ttaatttgag atctgaaaca acctgtcatt   3600

actctgatat cctgaacgtt taaggattat ggaagaagac taaagtgttt gaaatcattc   3660

atatttgaaa tttttatcat tagcttaaaa attactctca gtattgttaa aaaaaaaaaa   3720

aagtagaggc tggccaaaga ttatatacag atattttctt aaagcaggaa actaatgttg   3780

cctaaaagtc aaggtagttt gtgaagacaa tctgtcaata tggttgtcca tctctctaaa   3840

gaaaagcagg ctgggcgctg tggctcatgc ctataatccc aatactttgg gaggccgagg   3900

caggcggatc acaaggtcag gagtttgaaa ccagcctggc caacatggtg aaacctcgtc   3960

tctact                                                              3966


<210>  1576
<211>  512
<212>  PRT
<213>  Homo sapiens

<400>  1576

Met Glu Met Gln Ser Tyr Tyr Ala Lys Leu Leu Gly Glu Leu Asn Glu 
1               5                   10                  15


Gln Arg Lys Arg Asp Phe Phe Cys Asp Cys Ser Ile Ile Val Glu Gly 
            20                  25                  30


Arg Ile Phe Lys Ala His Arg Asn Ile Leu Phe Ala Asn Ser Gly Tyr 
        35                  40                  45


Phe Arg Ala Leu Leu Ile His Tyr Ile Gln Asp Ser Gly Arg His Ser 
    50                  55                  60


Thr Ala Ser Leu Asp Ile Val Thr Ser Asp Ala Phe Ser Ile Ile Leu 
65                  70                  75                  80


Asp Phe Leu Tyr Ser Gly Lys Leu Asp Leu Cys Gly Glu Asn Val Ile 
                85                  90                  95


Glu Val Met Ser Ala Ala Ser Tyr Leu Gln Met Asn Asp Val Val Asn 
            100                 105                 110


Phe Cys Lys Thr Tyr Ile Arg Ser Ser Leu Asp Ile Cys Arg Lys Met 
        115                 120                 125


Glu Lys Glu Ala Ala Val Ala Ala Ala Val Ala Ala Ala Ala Ala Ala 
    130                 135                 140


Ala Ala Ala Ala Ala Ala Ala Ala Ala His Gln Val Asp Ser Glu Ser 
145                 150                 155                 160


Pro Ser Ser Gly Arg Glu Gly Thr Ser Cys Gly Thr Lys Ser Leu Val 
                165                 170                 175


Ser Ser Pro Ala Glu Gly Glu Lys Ser Val Glu Cys Leu Arg Glu Ser 
            180                 185                 190


Pro Cys Gly Asp Cys Gly Asp Cys His Pro Leu Glu Leu Val Val Arg 
        195                 200                 205


Asp Ser Leu Gly Gly Gly Ser Ala Asp Ser Asn Leu Ser Thr Pro Pro 
    210                 215                 220


Lys Arg Ile Glu Pro Lys Val Glu Phe Asp Ala Asp Glu Val Glu Val 
225                 230                 235                 240


Asp Val Gly Glu Gln Leu Gln Gln Tyr Ala Ala Pro Leu Asn Leu Ala 
                245                 250                 255


His Val Glu Glu Ala Leu Pro Ser Gly Gln Ala Val Asp Leu Ala Tyr 
            260                 265                 270


Ser Asn Tyr His Val Lys Gln Phe Leu Glu Ala Leu Leu Arg Asn Ser 
        275                 280                 285


Ala Ala Pro Ser Lys Asp Asp Ala Asp His His Phe Ser Arg Ser Leu 
    290                 295                 300


Glu Gly Arg Pro Glu Gly Ala Gly Val Ala Met Ser Ser Met Met Asp 
305                 310                 315                 320


Val Gln Ala Asp Trp Tyr Gly Glu Asp Ser Gly Asp Val Leu Val Val 
                325                 330                 335


Pro Ile Lys Leu His Lys Cys Pro Phe Cys Pro Tyr Thr Ala Lys Gln 
            340                 345                 350


Lys Gly Ile Leu Lys Arg His Ile Arg Ser His Thr Gly Glu Arg Pro 
        355                 360                 365


Tyr Pro Cys Glu Thr Cys Gly Lys Arg Phe Thr Arg Gln Glu His Leu 
    370                 375                 380


Arg Ser His Ala Leu Ser Val His Arg Ser Asn Arg Pro Ile Ile Cys 
385                 390                 395                 400


Lys Gly Cys Arg Arg Thr Phe Thr Ser His Leu Ser Gln Gly Leu Arg 
                405                 410                 415


Arg Phe Gly Leu Cys Asp Ser Cys Thr Cys Val Thr Asp Thr Pro Asp 
            420                 425                 430


Asp Asp Asp Asp Leu Met Pro Ile Asn Leu Ser Leu Val Glu Ala Ser 
        435                 440                 445


Ser Glu Ser Gln Glu Lys Ser Asp Thr Asp Asn Asp Trp Pro Ile Tyr 
    450                 455                 460


Val Glu Ser Glu Ile Gly Ser His Tyr Val Ala Gln Ala Ser Leu Glu 
465                 470                 475                 480


Leu Leu Ala Leu Ser Gln Pro Pro Ala Ser Ala Ser Gln Ser Ala Gly 
                485                 490                 495


Ile Thr Asp Gly Val Ser Leu Cys Cys Pro Gly Arg Ser Thr Val Ala 
            500                 505                 510


<210>  1577
<211>  2018
<212>  DNA
<213>  Homo sapiens

<400>  1577
cctaaaccaa atccccagat cctagaaatc cagcccttct gccctccgga ggcgcctttc     60

ccaacgtaaa gtacaatttt aaatttcagc tcctgactaa aatcatgatc cgcagtcaac    120

tgctagagaa tctgggcacc ccggtgtctc tggagcgtgc agcgagtgtg ggcaagggca    180

gggggagtgg gcgaagctgc tggttggtgc ctgaaatctg tgcgttgccc ctttaattgt    240

gtccccagcc ctcgggcgtt tctgtccaac gcccacgtca gcaaatacct tttgtttctc    300

tcacgttggg gctacttgtt ttagggcgca aaggaacggc ctcgaaaggg ggtccttccc    360

cagccgagaa ccaggaatct tccctcggcc cgcgcgcgcg accggccggt gcgccgcggc    420

ccgcggacaa tcctccaaac acagactgtt tgacttagaa tcttcccttt tttactccat    480

tcaagagcag cattcataaa tttccagaat ggagatctcc tctcatcagt ctcacctcct    540

gcagcaactg aacgagcagc gcaggcaaga tgtattttgt gactgcagta ttctagttga    600

agggaaggtc ttcaaagcac atcgaaatgt attattcgct agtagcggct actttaaaat    660

gcttctttct cagaattcaa aggagacgag tcagccaacc acagctacat ttcaggcttt    720

ctcccctgac acttttacag ttatcttgga cttcgtatat tctggcaaac tgtctcttac    780

tggtcagaat gtcatagaag tgatgtcggc tgctagcttc cttcagatga ctgatgtcat    840

aagtgtatgt aagactttta ttaaatcttc cttagacatt agtgagaaag aaaaagatcg    900

ctatttcagt ctctcagata aagatgccaa ttctaatggt gtagaacgtt cctcttttta    960

tagtggtggc tggcaagaag gaagcagttc tccacgttct cacctaagcc cagagcaagg   1020

aacaggtata ataagtggaa aatcttggaa taagtataat tatcatccag cctcccagaa   1080

gaatactcaa caacccttgg ccaagcatga accaaggaaa gagtccatta aaaagaccaa   1140

acatttgaga ttgtcacagc cttctgaagt tactcattat aagtcaagca aacgagaagt   1200

acgaacatct gattcttcca gccatgtttc ccagtctgaa gaacaagcac agattgatgc   1260

tgaaatggac tctactcctg ttggctatca gtacggtcaa ggatctgatg tcacatccaa   1320

aagctttcca gatgatctgc ctcggatgcg attcaagtgc ccgtactgca cacatgtggt   1380

gaagcggaag gcagacctaa agcgccacct tcgttgtcat acaggagaaa ggccctatcc   1440

atgtcaagct tgtggaaaaa gatttagcag gctagaccat ctaagtagcc attttcgaac   1500

aatggagata aggattccag atggcacttg agtgaagatg agaatagatc ctatgtggag   1560

attgtagaag atgggtctgg tgatctggtc atccaacagg ttgatgatag tgaagaagaa   1620

gaagaaaaag aaattaagcc caacattagg tagctgtaat gtgaaccaac agagctggca   1680

tgtctgcaat ttacattgac ttcctgtatc tctctctttc tatggtcgga gtctagttaa   1740

caaatttatc acactgactt taaagaaatg atctgatata acttgcatgc tttctgaaca   1800

ggccattgta tccattctga actttgttgc cctaaaatgt gttgctgcac tggaaagaaa   1860

gaactagctt gagttggctt gatggatgaa caattatcct cttactttca ttacaatcct   1920

cttactttat tccagagata cctttttctt ttaatattgg aggatctact tagcaaactt   1980

ttttcaaaga aaatacttta aataaattca ccacaacc                           2018


<210>  1578
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  1578

Met Glu Ile Ser Ser His Gln Ser His Leu Leu Gln Gln Leu Asn Glu 
1               5                   10                  15


Gln Arg Arg Gln Asp Val Phe Cys Asp Cys Ser Ile Leu Val Glu Gly 
            20                  25                  30


Lys Val Phe Lys Ala His Arg Asn Val Leu Phe Ala Ser Ser Gly Tyr 
        35                  40                  45


Phe Lys Met Leu Leu Ser Gln Asn Ser Lys Glu Thr Ser Gln Pro Thr 
    50                  55                  60


Thr Ala Thr Phe Gln Ala Phe Ser Pro Asp Thr Phe Thr Val Ile Leu 
65                  70                  75                  80


Asp Phe Val Tyr Ser Gly Lys Leu Ser Leu Thr Gly Gln Asn Val Ile 
                85                  90                  95


Glu Val Met Ser Ala Ala Ser Phe Leu Gln Met Thr Asp Val Ile Ser 
            100                 105                 110


Val Cys Lys Thr Phe Ile Lys Ser Ser Leu Asp Ile Ser Glu Lys Glu 
        115                 120                 125


Lys Asp Arg Tyr Phe Ser Leu Ser Asp Lys Asp Ala Asn Ser Asn Gly 
    130                 135                 140


Val Glu Arg Ser Ser Phe Tyr Ser Gly Gly Trp Gln Glu Gly Ser Ser 
145                 150                 155                 160


Ser Pro Arg Ser His Leu Ser Pro Glu Gln Gly Thr Gly Ile Ile Ser 
                165                 170                 175


Gly Lys Ser Trp Asn Lys Tyr Asn Tyr His Pro Ala Ser Gln Lys Asn 
            180                 185                 190


Thr Gln Gln Pro Leu Ala Lys His Glu Pro Arg Lys Glu Ser Ile Lys 
        195                 200                 205


Lys Thr Lys His Leu Arg Leu Ser Gln Pro Ser Glu Val Thr His Tyr 
    210                 215                 220


Lys Ser Ser Lys Arg Glu Val Arg Thr Ser Asp Ser Ser Ser His Val 
225                 230                 235                 240


Ser Gln Ser Glu Glu Gln Ala Gln Ile Asp Ala Glu Met Asp Ser Thr 
                245                 250                 255


Pro Val Gly Tyr Gln Tyr Gly Gln Gly Ser Asp Val Thr Ser Lys Ser 
            260                 265                 270


Phe Pro Asp Asp Leu Pro Arg Met Arg Phe Lys Cys Pro Tyr Cys Thr 
        275                 280                 285


His Val Val Lys Arg Lys Ala Asp Leu Lys Arg His Leu Arg Cys His 
    290                 295                 300


Thr Gly Glu Arg Pro Tyr Pro Cys Gln Ala Cys Gly Lys Arg Phe Ser 
305                 310                 315                 320


Arg Leu Asp His Leu Ser Ser His Phe Arg Thr Met Glu Ile Arg Ile 
                325                 330                 335


Pro Asp Gly Thr 
            340


<210>  1579
<211>  2206
<212>  DNA
<213>  Homo sapiens

<400>  1579
cctaaaccaa atccccagat cctagaaatc cagcccttct gccctccgga ggcgcctttc     60

ccaacgtaaa gtacaatttt aaatttcagc tcctgactaa aatcatgatc cgcagtcaac    120

tgctagagaa tctgggcacc ccggtgtctc tggagcgtgc agcgagtgtg ggcaagggca    180

gggggagtgg gcgaagctgc tggttggtgc ctgaaatctg tgcgttgccc ctttaattgt    240

gtccccagcc ctcgggcgtt tctgtccaac gcccacgtca gcaaatacct tttgtttctc    300

tcacgttggg gctacttgtt ttagggcgca aaggaacggc ctcgaaaggg ggtccttccc    360

cagccgagaa ccaggaatct tccctcggcc cgcgcgcgcg accggccggt gcgccgcggc    420

ccgcggacaa tcctccaaac acagactgtt tgacttagaa tcttcccttt tttactccat    480

tcaagagcag cattcataaa tttccagaat ggagatctcc tctcatcagt ctcacctcct    540

gcagcaactg aacgagcagc gcaggcaaga tgtattttgt gactgcagta ttctagttga    600

agggaaggtc ttcaaagcac atcgaaatgt attattcgct agtagcggct actttaaaat    660

gcttctttct cagaattcaa aggagacgag tcagccaacc acagctacat ttcaggcttt    720

ctcccctgac acttttacag ttatcttgga cttcgtatat tctggcaaac tgtctcttac    780

tggtcagaat gtcatagaag tgatgtcggc tgctagcttc cttcagatga ctgatgtcat    840

aagtgtatgt aagactttta ttaaatcttc cttagacatt agtgagaaag aaaaagatcg    900

ctatttcagt ctctcagata aagatgccaa ttctaatggt gtagaacgtt cctcttttta    960

tagtggtggc tggcaagaag gaagcagttc tccacgttct cacctaagcc cagagcaagg   1020

aacaggtata ataagtggaa aatcttggaa taagtataat tatcatccag cctcccagaa   1080

gaatactcaa caacccttgg ccaagcatga accaaggaaa gagtccatta aaaagaccaa   1140

acatttgaga ttgtcacagc cttctgaagt tactcattat aagtcaagca aacgagaagt   1200

acgaacatct gattcttcca gccatgtttc ccagtctgaa gaacaagcac agattgatgc   1260

tgaaatggac tctactcctg ttggctatca gtacggtcaa ggatctgatg tcacatccaa   1320

aagctttcca gatgatctgc ctcggatgcg attcaagtgc ccgtactgca cacatgtggt   1380

gaagcggaag gcagacctaa agcgccacct tcgttgtcat acaggagaaa ggccctatcc   1440

atgtcaagct tgtggaaaaa gatttagcag gctagaccat ctaagtagcc attttcgaac   1500

aattcaccag gcatgtaaac tcatctgcag aaaatgtaaa cgtcatgtga cagatctaac   1560

agggcaagtg gtacaggagg gaaccaggcg ctacagactg tgtaatgagt gtcttgcaga   1620

atttggcata gacagcctcc ccattgactt ggaagctgaa caacatctta tgtccccatc   1680

agatggagat aaggattcca gatggcactt gagtgaagat gagaatagat cctatgtgga   1740

gattgtagaa gatgggtctg gtgatctggt catccaacag gttgatgata gtgaagaaga   1800

agaagaaaaa gaaattaagc ccaacattag gtagctgtaa tgtgaaccaa cagagctggc   1860

atgtctgcaa tttacattga cttcctgtat ctctctcttt ctatggtcgg agtctagtta   1920

acaaatttat cacactgact ttaaagaaat gatctgatat aacttgcatg ctttctgaac   1980

aggccattgt atccattctg aactttgttg ccctaaaatg tgttgctgca ctggaaagaa   2040

agaactagct tgagttggct tgatggatga acaattatcc tcttactttc attacaatcc   2100

tcttacttta ttccagagat acctttttct tttaatattg gaggatctac ttagcaaact   2160

tttttcaaag aaaatacttt aaataaattc accacaacca aacttt                  2206


<210>  1580
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  1580

Met Glu Ile Ser Ser His Gln Ser His Leu Leu Gln Gln Leu Asn Glu 
1               5                   10                  15


Gln Arg Arg Gln Asp Val Phe Cys Asp Cys Ser Ile Leu Val Glu Gly 
            20                  25                  30


Lys Val Phe Lys Ala His Arg Asn Val Leu Phe Ala Ser Ser Gly Tyr 
        35                  40                  45


Phe Lys Met Leu Leu Ser Gln Asn Ser Lys Glu Thr Ser Gln Pro Thr 
    50                  55                  60


Thr Ala Thr Phe Gln Ala Phe Ser Pro Asp Thr Phe Thr Val Ile Leu 
65                  70                  75                  80


Asp Phe Val Tyr Ser Gly Lys Leu Ser Leu Thr Gly Gln Asn Val Ile 
                85                  90                  95


Glu Val Met Ser Ala Ala Ser Phe Leu Gln Met Thr Asp Val Ile Ser 
            100                 105                 110


Val Cys Lys Thr Phe Ile Lys Ser Ser Leu Asp Ile Ser Glu Lys Glu 
        115                 120                 125


Lys Asp Arg Tyr Phe Ser Leu Ser Asp Lys Asp Ala Asn Ser Asn Gly 
    130                 135                 140


Val Glu Arg Ser Ser Phe Tyr Ser Gly Gly Trp Gln Glu Gly Ser Ser 
145                 150                 155                 160


Ser Pro Arg Ser His Leu Ser Pro Glu Gln Gly Thr Gly Ile Ile Ser 
                165                 170                 175


Gly Lys Ser Trp Asn Lys Tyr Asn Tyr His Pro Ala Ser Gln Lys Asn 
            180                 185                 190


Thr Gln Gln Pro Leu Ala Lys His Glu Pro Arg Lys Glu Ser Ile Lys 
        195                 200                 205


Lys Thr Lys His Leu Arg Leu Ser Gln Pro Ser Glu Val Thr His Tyr 
    210                 215                 220


Lys Ser Ser Lys Arg Glu Val Arg Thr Ser Asp Ser Ser Ser His Val 
225                 230                 235                 240


Ser Gln Ser Glu Glu Gln Ala Gln Ile Asp Ala Glu Met Asp Ser Thr 
                245                 250                 255


Pro Val Gly Tyr Gln Tyr Gly Gln Gly Ser Asp Val Thr Ser Lys Ser 
            260                 265                 270


Phe Pro Asp Asp Leu Pro Arg Met Arg Phe Lys Cys Pro Tyr Cys Thr 
        275                 280                 285


His Val Val Lys Arg Lys Ala Asp Leu Lys Arg His Leu Arg Cys His 
    290                 295                 300


Thr Gly Glu Arg Pro Tyr Pro Cys Gln Ala Cys Gly Lys Arg Phe Ser 
305                 310                 315                 320


Arg Leu Asp His Leu Ser Ser His Phe Arg Thr Ile His Gln Ala Cys 
                325                 330                 335


Lys Leu Ile Cys Arg Lys Cys Lys Arg His Val Thr Asp Leu Thr Gly 
            340                 345                 350


Gln Val Val Gln Glu Gly Thr Arg Arg Tyr Arg Leu Cys Asn Glu Cys 
        355                 360                 365


Leu Ala Glu Phe Gly Ile Asp Ser Leu Pro Ile Asp Leu Glu Ala Glu 
    370                 375                 380


Gln His Leu Met Ser Pro Ser Asp Gly Asp Lys Asp Ser Arg Trp His 
385                 390                 395                 400


Leu Ser Glu Asp Glu Asn Arg Ser Tyr Val Glu Ile Val Glu Asp Gly 
                405                 410                 415


Ser Gly Asp Leu Val Ile Gln Gln Val Asp Asp Ser Glu Glu Glu Glu 
            420                 425                 430


Glu Lys Glu Ile Lys Pro Asn Ile Arg 
        435                 440


<210>  1581
<211>  2545
<212>  DNA
<213>  Homo sapiens

<400>  1581
cctaaaccaa atccccagat cctagaaatc cagcccttct gccctccgga ggcgcctttc     60

ccaacgtaaa gtacaatttt aaatttcagc tcctgactaa aatcatgatc cgcagtcaac    120

tgctagagaa tctgggcacc ccggtgtctc tggagcgtgc agcgagtgtg ggcaagggca    180

gggggagtgg gcgaagctgc tggttggtgc ctgaaatctg tgcgttgccc ctttaattgt    240

gtccccagcc ctcgggcgtt tctgtccaac gcccacgtca gcaaatacct tttgtttctc    300

tcacgttggg gctacttgtt ttagggcgca aaggaacggc ctcgaaaggg ggtccttccc    360

cagccgagaa ccaggaatct tccctcggcc cgcgcgcgcg accggccggt gcgccgcggc    420

ccgcggacaa tcctccaaac acagactgtt tgacttagaa tcttcccttt tttactccat    480

tcaagagcag cattcataaa tttccagaat ggagatctcc tctcatcagt ctcacctcct    540

gcagcaactg aacgagcagc gcaggcaaga tgtattttgt gactgcagta ttctagttga    600

agggaaggtc ttcaaagcac atcgaaatgt attattcgct agtagcggct actttaaaat    660

gcttctttct cagaattcaa aggagacgag tcagccaacc acagctacat ttcaggcttt    720

ctcccctgac acttttacag ttatcttgga cttcgtatat tctggcaaac tgtctcttac    780

tggtcagaat gtcatagaag tgatgtcggc tgctagcttc cttcagatga ctgatgtcat    840

aagtgtatgt aagactttta ttaaatcttc cttagacatt agtgagaaag aaaaagatcg    900

ctatttcagt ctctcagata aagatgccaa ttctaatggt gtagaacgtt cctcttttta    960

tagtggtggc tggcaagaag gaagcagttc tccacgttct cacctaagcc cagagcaagg   1020

aacaggtata ataagtggaa aatcttggaa taagtataat tatcatccag cctcccagaa   1080

gaatactcaa caacccttgg ccaagcatga accaaggaaa gagtccatta aaaagaccaa   1140

acatttgaga ttgtcacagc cttctgaagt tactcattat aagtcaagca aacgagaagt   1200

acgaacatct gattcttcca gccatgtttc ccagtctgaa gaacaagcac agattgatgc   1260

tgaaatggac tctactcctg ttggctatca gtacggtcaa ggatctgatg tcacatccaa   1320

aagctttcca gatgatctgc ctcggatgcg attcaagtgc ccgtactgca cacatgtggt   1380

gaagcggaag gcagacctaa agcgccacct tcgttgtcat acaggagaaa ggccctatcc   1440

atgtcaagct tgtggaaaaa gatttagcag gctagaccat ctaagtagcc attttcgaac   1500

aatggagata aggattccag atggcacttg agtgaagatg agaatagatc ctatgtggag   1560

attgtagaag atgggtctgg tgatctggtc atccaacagg ttgatgatag tgaagaagaa   1620

gaagaaaaag aaattaagcc caacattagg tagctgtaat gtgaaccaac agagctggca   1680

tgtctgcaat ttacattgac ttcctgtatc tctctctttc tatggtcgga gtctagttaa   1740

caaatttatc acactgactt taaagaaatg atctgatata acttgcatgc tttctgaaca   1800

ggccattgta tccattctga actttgttgc cctaaaatgt gttgctgcac tggaaagaaa   1860

gaactagctt gagttggctt gatggatgaa caattatcct cttactttca ttacaatcct   1920

cttactttat tccagagata cctttttctt ttaatattgg aggatctact tagcaaactt   1980

ttttcaaaga aaatacttta aataaattca ccacaaccaa actttatgta agacaatttc   2040

aaggtgtttc aaaaacacat aactaccaat gtttaatttc acagggaacc agttaagagc   2100

acatttaagg atctggcaac ccaccttact aaacaaatta gtctttctat taatttgaga   2160

tctgaaacaa cctgtcatta ctctgatatc ctgaacgttt aaggattatg gaagaagact   2220

aaagtgtttg aaatcattca tatttgaaat ttttatcatt agcttaaaaa ttactctcag   2280

tattgttaaa aaaaaaaaaa agtagaggct ggccaaagat tatatacaga tattttctta   2340

aagcaggaaa ctaatgttgc ctaaaagtca aggtagtttg tgaagacaat ctgtcaatat   2400

ggttgtccat ctctctaaag aaaagcaggc tgggcgctgt ggctcatgcc tataatccca   2460

atactttggg aggccgaggc aggcggatca caaggtcagg agtttgaaac cagcctggcc   2520

aacatggtga aacctcgtct ctact                                         2545


<210>  1582
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  1582

Met Glu Ile Ser Ser His Gln Ser His Leu Leu Gln Gln Leu Asn Glu 
1               5                   10                  15


Gln Arg Arg Gln Asp Val Phe Cys Asp Cys Ser Ile Leu Val Glu Gly 
            20                  25                  30


Lys Val Phe Lys Ala His Arg Asn Val Leu Phe Ala Ser Ser Gly Tyr 
        35                  40                  45


Phe Lys Met Leu Leu Ser Gln Asn Ser Lys Glu Thr Ser Gln Pro Thr 
    50                  55                  60


Thr Ala Thr Phe Gln Ala Phe Ser Pro Asp Thr Phe Thr Val Ile Leu 
65                  70                  75                  80


Asp Phe Val Tyr Ser Gly Lys Leu Ser Leu Thr Gly Gln Asn Val Ile 
                85                  90                  95


Glu Val Met Ser Ala Ala Ser Phe Leu Gln Met Thr Asp Val Ile Ser 
            100                 105                 110


Val Cys Lys Thr Phe Ile Lys Ser Ser Leu Asp Ile Ser Glu Lys Glu 
        115                 120                 125


Lys Asp Arg Tyr Phe Ser Leu Ser Asp Lys Asp Ala Asn Ser Asn Gly 
    130                 135                 140


Val Glu Arg Ser Ser Phe Tyr Ser Gly Gly Trp Gln Glu Gly Ser Ser 
145                 150                 155                 160


Ser Pro Arg Ser His Leu Ser Pro Glu Gln Gly Thr Gly Ile Ile Ser 
                165                 170                 175


Gly Lys Ser Trp Asn Lys Tyr Asn Tyr His Pro Ala Ser Gln Lys Asn 
            180                 185                 190


Thr Gln Gln Pro Leu Ala Lys His Glu Pro Arg Lys Glu Ser Ile Lys 
        195                 200                 205


Lys Thr Lys His Leu Arg Leu Ser Gln Pro Ser Glu Val Thr His Tyr 
    210                 215                 220


Lys Ser Ser Lys Arg Glu Val Arg Thr Ser Asp Ser Ser Ser His Val 
225                 230                 235                 240


Ser Gln Ser Glu Glu Gln Ala Gln Ile Asp Ala Glu Met Asp Ser Thr 
                245                 250                 255


Pro Val Gly Tyr Gln Tyr Gly Gln Gly Ser Asp Val Thr Ser Lys Ser 
            260                 265                 270


Phe Pro Asp Asp Leu Pro Arg Met Arg Phe Lys Cys Pro Tyr Cys Thr 
        275                 280                 285


His Val Val Lys Arg Lys Ala Asp Leu Lys Arg His Leu Arg Cys His 
    290                 295                 300


Thr Gly Glu Arg Pro Tyr Pro Cys Gln Ala Cys Gly Lys Arg Phe Ser 
305                 310                 315                 320


Arg Leu Asp His Leu Ser Ser His Phe Arg Thr Met Glu Ile Arg Ile 
                325                 330                 335


Pro Asp Gly Thr 
            340


<210>  1583
<211>  2726
<212>  DNA
<213>  Homo sapiens

<400>  1583
cctaaaccaa atccccagat cctagaaatc cagcccttct gccctccgga ggcgcctttc     60

ccaacgtaaa gtacaatttt aaatttcagc tcctgactaa aatcatgatc cgcagtcaac    120

tgctagagaa tctgggcacc ccggtgtctc tggagcgtgc agcgagtgtg ggcaagggca    180

gggggagtgg gcgaagctgc tggttggtgc ctgaaatctg tgcgttgccc ctttaattgt    240

gtccccagcc ctcgggcgtt tctgtccaac gcccacgtca gcaaatacct tttgtttctc    300

tcacgttggg gctacttgtt ttagggcgca aaggaacggc ctcgaaaggg ggtccttccc    360

cagccgagaa ccaggaatct tccctcggcc cgcgcgcgcg accggccggt gcgccgcggc    420

ccgcggacaa tcctccaaac acagactgtt tgacttagaa tcttcccttt tttactccat    480

tcaagagcag cattcataaa tttccagaat ggagatctcc tctcatcagt ctcacctcct    540

gcagcaactg aacgagcagc gcaggcaaga tgtattttgt gactgcagta ttctagttga    600

agggaaggtc ttcaaagcac atcgaaatgt attattcgct agtagcggct actttaaaat    660

gcttctttct cagaattcaa aggagacgag tcagccaacc acagctacat ttcaggcttt    720

ctcccctgac acttttacag ttatcttgga cttcgtatat tctggcaaac tgtctcttac    780

tggtcagaat gtcatagaag tgatgtcggc tgctagcttc cttcagatga ctgatgtcat    840

aagtgtatgt aagactttta ttaaatcttc cttagacatt agtgagaaag aaaaagatcg    900

ctatttcagt ctctcagata aagatgccaa ttctaatggt gtagaacgtt cctcttttta    960

tagtggtggc tggcaagaag gaagcagttc tccacgttct cacctaagcc cagagcaagg   1020

aacaggtata ataagtggaa aatcttggaa taagtataat tatcatccag cctcccagaa   1080

gaatactcaa caacccttgg ccaagcatga accaaggaaa gagtccatta aaaagaccaa   1140

acatttgaga ttgtcacagc cttctgaagt tactcattat aagtcaagca aacgagaagt   1200

acgaacatct gattcttcca gccatgtttc ccagtctgaa gaacaagcac agattgatgc   1260

tgaaatggac tctactcctg ttggctatca gtacggtcaa ggatctgatg tcacatccaa   1320

aagctttcca gatgatctgc ctcggatgcg attcaagtgc ccgtactgca cacatgtggt   1380

gaagcggaag gcagacctaa agcgccacct tcgttgtcat acaggagaaa ggccctatcc   1440

atgtcaagct tgtggaaaaa gatttagcag gctagaccat ctaagtagcc attttcgaac   1500

aattcaccag gcatgtaaac tcatctgcag aaaatgtaaa cgtcatgtga cagatctaac   1560

agggcaagtg gtacaggagg gaaccaggcg ctacagactg tgtaatgagt gtcttgcaga   1620

atttggcata gacagcctcc ccattgactt ggaagctgaa caacatctta tgtccccatc   1680

agatggagat aaggattcca gatggcactt gagtgaagat gagaatagat cctatgtgga   1740

gattgtagaa gatgggtctg gtgatctggt catccaacag gttgatgata gtgaagaaga   1800

agaagaaaaa gaaattaagc ccaacattag gtagctgtaa tgtgaaccaa cagagctggc   1860

atgtctgcaa tttacattga cttcctgtat ctctctcttt ctatggtcgg agtctagtta   1920

acaaatttat cacactgact ttaaagaaat gatctgatat aacttgcatg ctttctgaac   1980

aggccattgt atccattctg aactttgttg ccctaaaatg tgttgctgca ctggaaagaa   2040

agaactagct tgagttggct tgatggatga acaattatcc tcttactttc attacaatcc   2100

tcttacttta ttccagagat acctttttct tttaatattg gaggatctac ttagcaaact   2160

tttttcaaag aaaatacttt aaataaattc accacaacca aactttatgt aagacaattt   2220

caaggtgttt caaaaacaca taactaccaa tgtttaattt cacagggaac cagttaagag   2280

cacatttaag gatctggcaa cccaccttac taaacaaatt agtctttcta ttaatttgag   2340

atctgaaaca acctgtcatt actctgatat cctgaacgtt taaggattat ggaagaagac   2400

taaagtgttt gaaatcattc atatttgaaa tttttatcat tagcttaaaa attactctca   2460

gtattgttaa aaaaaaaaaa aagtagaggc tggccaaaga ttatatacag atattttctt   2520

aaagcaggaa actaatgttg cctaaaagtc aaggtagttt gtgaagacaa tctgtcaata   2580

tggttgtcca tctctctaaa gaaaagcagg ctgggcgctg tggctcatgc ctataatccc   2640

aatactttgg gaggccgagg caggcggatc acaaggtcag gagtttgaaa ccagcctggc   2700

caacatggtg aaacctcgtc tctact                                        2726


<210>  1584
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  1584

Met Glu Ile Ser Ser His Gln Ser His Leu Leu Gln Gln Leu Asn Glu 
1               5                   10                  15


Gln Arg Arg Gln Asp Val Phe Cys Asp Cys Ser Ile Leu Val Glu Gly 
            20                  25                  30


Lys Val Phe Lys Ala His Arg Asn Val Leu Phe Ala Ser Ser Gly Tyr 
        35                  40                  45


Phe Lys Met Leu Leu Ser Gln Asn Ser Lys Glu Thr Ser Gln Pro Thr 
    50                  55                  60


Thr Ala Thr Phe Gln Ala Phe Ser Pro Asp Thr Phe Thr Val Ile Leu 
65                  70                  75                  80


Asp Phe Val Tyr Ser Gly Lys Leu Ser Leu Thr Gly Gln Asn Val Ile 
                85                  90                  95


Glu Val Met Ser Ala Ala Ser Phe Leu Gln Met Thr Asp Val Ile Ser 
            100                 105                 110


Val Cys Lys Thr Phe Ile Lys Ser Ser Leu Asp Ile Ser Glu Lys Glu 
        115                 120                 125


Lys Asp Arg Tyr Phe Ser Leu Ser Asp Lys Asp Ala Asn Ser Asn Gly 
    130                 135                 140


Val Glu Arg Ser Ser Phe Tyr Ser Gly Gly Trp Gln Glu Gly Ser Ser 
145                 150                 155                 160


Ser Pro Arg Ser His Leu Ser Pro Glu Gln Gly Thr Gly Ile Ile Ser 
                165                 170                 175


Gly Lys Ser Trp Asn Lys Tyr Asn Tyr His Pro Ala Ser Gln Lys Asn 
            180                 185                 190


Thr Gln Gln Pro Leu Ala Lys His Glu Pro Arg Lys Glu Ser Ile Lys 
        195                 200                 205


Lys Thr Lys His Leu Arg Leu Ser Gln Pro Ser Glu Val Thr His Tyr 
    210                 215                 220


Lys Ser Ser Lys Arg Glu Val Arg Thr Ser Asp Ser Ser Ser His Val 
225                 230                 235                 240


Ser Gln Ser Glu Glu Gln Ala Gln Ile Asp Ala Glu Met Asp Ser Thr 
                245                 250                 255


Pro Val Gly Tyr Gln Tyr Gly Gln Gly Ser Asp Val Thr Ser Lys Ser 
            260                 265                 270


Phe Pro Asp Asp Leu Pro Arg Met Arg Phe Lys Cys Pro Tyr Cys Thr 
        275                 280                 285


His Val Val Lys Arg Lys Ala Asp Leu Lys Arg His Leu Arg Cys His 
    290                 295                 300


Thr Gly Glu Arg Pro Tyr Pro Cys Gln Ala Cys Gly Lys Arg Phe Ser 
305                 310                 315                 320


Arg Leu Asp His Leu Ser Ser His Phe Arg Thr Ile His Gln Ala Cys 
                325                 330                 335


Lys Leu Ile Cys Arg Lys Cys Lys Arg His Val Thr Asp Leu Thr Gly 
            340                 345                 350


Gln Val Val Gln Glu Gly Thr Arg Arg Tyr Arg Leu Cys Asn Glu Cys 
        355                 360                 365


Leu Ala Glu Phe Gly Ile Asp Ser Leu Pro Ile Asp Leu Glu Ala Glu 
    370                 375                 380


Gln His Leu Met Ser Pro Ser Asp Gly Asp Lys Asp Ser Arg Trp His 
385                 390                 395                 400


Leu Ser Glu Asp Glu Asn Arg Ser Tyr Val Glu Ile Val Glu Asp Gly 
                405                 410                 415


Ser Gly Asp Leu Val Ile Gln Gln Val Asp Asp Ser Glu Glu Glu Glu 
            420                 425                 430


Glu Lys Glu Ile Lys Pro Asn Ile Arg 
        435                 440


<210>  1585
<211>  1023
<212>  DNA
<213>  Homo sapiens

<400>  1585
cttctgccct ccggaggcgc ctttcccaac gtaaagtaca attttaaatt tcagctcctg     60

actaaaatca tgatccgcag tcaactgcta gagaatctgg gcaccccggt gtctctggag    120

cgtgcagcga gtgtgggcaa gggcaggggg agtgggcgaa gctgctggtt ggtgcctgaa    180

atctggcgca aaggaacggc ctcgaaaggg ggtccttccc cagccgagaa ccaggaatct    240

tccctcggcc cgcgcgcgcg accggccggt gcgccgcggc ccgcggacaa tcctccaaac    300

acagactgtt tgacttagaa tcttcccttt tttactccat tcaagagcag cattcataaa    360

tttccaggtt ttggtaacca catgtgtctt ttcctcttca gaatggagat ctcctctcat    420

cagtctcacc tcctgcagca actgaacgag cagcgcaggc aagatgtatt ttgtgactgc    480

agtattctag ttgaagggaa ggtcttcaaa gcacatcgaa atgtattatt cgctagtagc    540

ggctacttta aaatgcttct ttctcagaat tcaaaggaga cgagtcagcc aaccacagct    600

acatttcagg ctttctcccc tgacactttt acagttatct tggacttcgt atattctggc    660

aaactgtctc ttactggtca gaatgtcata gaagtgatgt cggctgctag cttccttcag    720

atgactgatg tcataagtgt atgtaagact tttattaaat cttccttaga cattagtgag    780

aaagaaaaag atcgctattt cagtctctca gataaagatg ccaattctaa tggtgtagaa    840

cgttcctctt tttatagtgg tggctggcaa gaaggaagca gttctccacg ttctcaccta    900

agcccagagc aaggaacagg tataataagt ggaaaatctt ggaataagta taattatcat    960

ccagcctccc agaagaatac tcaacaaccc ttggccaagc atgaaccaag gaaagagtcc   1020

att                                                                 1023


<210>  1586
<211>  82
<212>  PRT
<213>  Homo sapiens

<400>  1586

Met Ile Arg Ser Gln Leu Leu Glu Asn Leu Gly Thr Pro Val Ser Leu 
1               5                   10                  15


Glu Arg Ala Ala Ser Val Gly Lys Gly Arg Gly Ser Gly Arg Ser Cys 
            20                  25                  30


Trp Leu Val Pro Glu Ile Trp Arg Lys Gly Thr Ala Ser Lys Gly Gly 
        35                  40                  45


Pro Ser Pro Ala Glu Asn Gln Glu Ser Ser Leu Gly Pro Arg Ala Arg 
    50                  55                  60


Pro Ala Gly Ala Pro Arg Pro Ala Asp Asn Pro Pro Asn Thr Asp Cys 
65                  70                  75                  80


Leu Thr 



<210>  1587
<211>  1888
<212>  DNA
<213>  Homo sapiens

<400>  1587
agcaaatacc ttttgtttct ctcacgttgg ggctacttgt tttagggcgc aaaggaacgg     60

cctcgaaagg gggtccttcc ccagccgaga accaggaatc ttccctggac aatcctccaa    120

acacagactg tttgacttag aatcttccct tttttactcc attcaagagc agcattcata    180

aatttccaga atggagatct cctctcatca gtctcacctc ctgcagcaac tgaacgagca    240

gcgcaggcaa gatgtatttt gtgactgcag tattctagtt gaagggaagg tcttcaaagc    300

acatcgaaat gtattattcg ctagtagcgg ctactttaaa atgcttcttt ctcagaattc    360

aaaggagacg agtcagccaa ccacagctac atttcaggct ttctcccctg acacttttac    420

agttatcttg gacttcgtat attctggcaa actgtctctt actggtcaga atgtcataga    480

agtgatgtcg gctgctagct tccttcagat gactgatgtc ataagtgtat gtaagacttt    540

tattaaatct tccttagaca ttagtgagaa agaaaaagat cgctatttca gtctctcaga    600

taaagatgcc aattctaatg gtgtagaacg ttcctctttt tatagtggtg gctggcaaga    660

aggaagcagt tctccacgtt ctcacctaag cccagagcaa ggaacaggta taataagtgg    720

aaaatcttgg aataagtata attatcatcc agcctcccag aagaatactc aacaaccctt    780

ggccaagcat gaaccaagga aagagtccat taaaaagacc aaacatttga gattgtcaca    840

gccttctgaa gttactcatt ataagtcaag caaacgagaa gtacgaacat ctgattcttc    900

cagccatgtt tcccagtctg aagaacaagc acagattgat gctgaaatgg actctactcc    960

tgttggctat cagtacggtc aaggatctga tgtcacatcc aaaagctttc cagatgatct   1020

gcctcggatg cgattcaagt gcccgtactg cacacatgtg gtgaagcgga aggcagacct   1080

aaagcgccac cttcgttgtc atacaggaga aaggccctat ccatgtcaag cttgtggaaa   1140

aagatttagc aggctagacc atctaagtag ccattttcga acaattcacc aggcatgtaa   1200

actcatctgc agaaaatgta aacgtcatgt gacagatcta acagggcaag tggtacagga   1260

gggaaccagg cgctacagac tgtgtaatga gtgtcttgca gaatttggca tagacagcct   1320

ccccattgac ttggaagctg aacaacatct tatgtcccca tcagatggag ataaggattc   1380

cagatggcac ttgagtgaag atgagaatag atcctatgtg gagattgtag aagatgggtc   1440

tggtgatctg gtcatccaac aggttgatga tagtgaagaa gaagaagaaa aagaaattaa   1500

gcccaacatt aggtagctgt aatgtgaacc aacagagctg gcatgtctgc aatttacatt   1560

gacttcctgt atctctctct ttctatggtc ggagtctagt taacaaattt atcacactga   1620

ctttaaagaa atgatctgat ataacttgca tgctttctga acaggccatt gtatccattc   1680

tgaactttgt tgccctaaaa tgtgttgctg cactggaaag aaagaactag cttgagttgg   1740

cttgatggat gaacaattat cctcttactt tcattacaat cctcttactt tattccagag   1800

ataccttttt cttttaatat tggaggatct acttagcaaa cttttttcaa agaaaatact   1860

ttaaataaat tcaccacaac caaacttt                                      1888


<210>  1588
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  1588

Met Glu Ile Ser Ser His Gln Ser His Leu Leu Gln Gln Leu Asn Glu 
1               5                   10                  15


Gln Arg Arg Gln Asp Val Phe Cys Asp Cys Ser Ile Leu Val Glu Gly 
            20                  25                  30


Lys Val Phe Lys Ala His Arg Asn Val Leu Phe Ala Ser Ser Gly Tyr 
        35                  40                  45


Phe Lys Met Leu Leu Ser Gln Asn Ser Lys Glu Thr Ser Gln Pro Thr 
    50                  55                  60


Thr Ala Thr Phe Gln Ala Phe Ser Pro Asp Thr Phe Thr Val Ile Leu 
65                  70                  75                  80


Asp Phe Val Tyr Ser Gly Lys Leu Ser Leu Thr Gly Gln Asn Val Ile 
                85                  90                  95


Glu Val Met Ser Ala Ala Ser Phe Leu Gln Met Thr Asp Val Ile Ser 
            100                 105                 110


Val Cys Lys Thr Phe Ile Lys Ser Ser Leu Asp Ile Ser Glu Lys Glu 
        115                 120                 125


Lys Asp Arg Tyr Phe Ser Leu Ser Asp Lys Asp Ala Asn Ser Asn Gly 
    130                 135                 140


Val Glu Arg Ser Ser Phe Tyr Ser Gly Gly Trp Gln Glu Gly Ser Ser 
145                 150                 155                 160


Ser Pro Arg Ser His Leu Ser Pro Glu Gln Gly Thr Gly Ile Ile Ser 
                165                 170                 175


Gly Lys Ser Trp Asn Lys Tyr Asn Tyr His Pro Ala Ser Gln Lys Asn 
            180                 185                 190


Thr Gln Gln Pro Leu Ala Lys His Glu Pro Arg Lys Glu Ser Ile Lys 
        195                 200                 205


Lys Thr Lys His Leu Arg Leu Ser Gln Pro Ser Glu Val Thr His Tyr 
    210                 215                 220


Lys Ser Ser Lys Arg Glu Val Arg Thr Ser Asp Ser Ser Ser His Val 
225                 230                 235                 240


Ser Gln Ser Glu Glu Gln Ala Gln Ile Asp Ala Glu Met Asp Ser Thr 
                245                 250                 255


Pro Val Gly Tyr Gln Tyr Gly Gln Gly Ser Asp Val Thr Ser Lys Ser 
            260                 265                 270


Phe Pro Asp Asp Leu Pro Arg Met Arg Phe Lys Cys Pro Tyr Cys Thr 
        275                 280                 285


His Val Val Lys Arg Lys Ala Asp Leu Lys Arg His Leu Arg Cys His 
    290                 295                 300


Thr Gly Glu Arg Pro Tyr Pro Cys Gln Ala Cys Gly Lys Arg Phe Ser 
305                 310                 315                 320


Arg Leu Asp His Leu Ser Ser His Phe Arg Thr Ile His Gln Ala Cys 
                325                 330                 335


Lys Leu Ile Cys Arg Lys Cys Lys Arg His Val Thr Asp Leu Thr Gly 
            340                 345                 350


Gln Val Val Gln Glu Gly Thr Arg Arg Tyr Arg Leu Cys Asn Glu Cys 
        355                 360                 365


Leu Ala Glu Phe Gly Ile Asp Ser Leu Pro Ile Asp Leu Glu Ala Glu 
    370                 375                 380


Gln His Leu Met Ser Pro Ser Asp Gly Asp Lys Asp Ser Arg Trp His 
385                 390                 395                 400


Leu Ser Glu Asp Glu Asn Arg Ser Tyr Val Glu Ile Val Glu Asp Gly 
                405                 410                 415


Ser Gly Asp Leu Val Ile Gln Gln Val Asp Asp Ser Glu Glu Glu Glu 
            420                 425                 430


Glu Lys Glu Ile Lys Pro Asn Ile Arg 
        435                 440


<210>  1589
<211>  2408
<212>  DNA
<213>  Homo sapiens

<400>  1589
agcaaatacc ttttgtttct ctcacgttgg ggctacttgt tttagggcgc aaaggaacgg     60

cctcgaaagg gggtccttcc ccagccgaga accaggaatc ttccctggac aatcctccaa    120

acacagactg tttgacttag aatcttccct tttttactcc attcaagagc agcattcata    180

aatttccaga atggagatct cctctcatca gtctcacctc ctgcagcaac tgaacgagca    240

gcgcaggcaa gatgtatttt gtgactgcag tattctagtt gaagggaagg tcttcaaagc    300

acatcgaaat gtattattcg ctagtagcgg ctactttaaa atgcttcttt ctcagaattc    360

aaaggagacg agtcagccaa ccacagctac atttcaggct ttctcccctg acacttttac    420

agttatcttg gacttcgtat attctggcaa actgtctctt actggtcaga atgtcataga    480

agtgatgtcg gctgctagct tccttcagat gactgatgtc ataagtgtat gtaagacttt    540

tattaaatct tccttagaca ttagtgagaa agaaaaagat cgctatttca gtctctcaga    600

taaagatgcc aattctaatg gtgtagaacg ttcctctttt tatagtggtg gctggcaaga    660

aggaagcagt tctccacgtt ctcacctaag cccagagcaa ggaacaggta taataagtgg    720

aaaatcttgg aataagtata attatcatcc agcctcccag aagaatactc aacaaccctt    780

ggccaagcat gaaccaagga aagagtccat taaaaagacc aaacatttga gattgtcaca    840

gccttctgaa gttactcatt ataagtcaag caaacgagaa gtacgaacat ctgattcttc    900

cagccatgtt tcccagtctg aagaacaagc acagattgat gctgaaatgg actctactcc    960

tgttggctat cagtacggtc aaggatctga tgtcacatcc aaaagctttc cagatgatct   1020

gcctcggatg cgattcaagt gcccgtactg cacacatgtg gtgaagcgga aggcagacct   1080

aaagcgccac cttcgttgtc atacaggaga aaggccctat ccatgtcaag cttgtggaaa   1140

aagatttagc aggctagacc atctaagtag ccattttcga acaattcacc aggcatgtaa   1200

actcatctgc agaaaatgta aacgtcatgt gacagatcta acagggcaag tggtacagga   1260

gggaaccagg cgctacagac tgtgtaatga gtgtcttgca gaatttggca tagacagcct   1320

ccccattgac ttggaagctg aacaacatct tatgtcccca tcagatggag ataaggattc   1380

cagatggcac ttgagtgaag atgagaatag atcctatgtg gagattgtag aagatgggtc   1440

tggtgatctg gtcatccaac aggttgatga tagtgaagaa gaagaagaaa aagaaattaa   1500

gcccaacatt aggtagctgt aatgtgaacc aacagagctg gcatgtctgc aatttacatt   1560

gacttcctgt atctctctct ttctatggtc ggagtctagt taacaaattt atcacactga   1620

ctttaaagaa atgatctgat ataacttgca tgctttctga acaggccatt gtatccattc   1680

tgaactttgt tgccctaaaa tgtgttgctg cactggaaag aaagaactag cttgagttgg   1740

cttgatggat gaacaattat cctcttactt tcattacaat cctcttactt tattccagag   1800

ataccttttt cttttaatat tggaggatct acttagcaaa cttttttcaa agaaaatact   1860

ttaaataaat tcaccacaac caaactttat gtaagacaat ttcaaggtgt ttcaaaaaca   1920

cataactacc aatgtttaat ttcacaggga accagttaag agcacattta aggatctggc   1980

aacccacctt actaaacaaa ttagtctttc tattaatttg agatctgaaa caacctgtca   2040

ttactctgat atcctgaacg tttaaggatt atggaagaag actaaagtgt ttgaaatcat   2100

tcatatttga aatttttatc attagcttaa aaattactct cagtattgtt aaaaaaaaaa   2160

aaaagtagag gctggccaaa gattatatac agatattttc ttaaagcagg aaactaatgt   2220

tgcctaaaag tcaaggtagt ttgtgaagac aatctgtcaa tatggttgtc catctctcta   2280

aagaaaagca ggctgggcgc tgtggctcat gcctataatc ccaatacttt gggaggccga   2340

ggcaggcgga tcacaaggtc aggagtttga aaccagcctg gccaacatgg tgaaacctcg   2400

tctctact                                                            2408


<210>  1590
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  1590

Met Glu Ile Ser Ser His Gln Ser His Leu Leu Gln Gln Leu Asn Glu 
1               5                   10                  15


Gln Arg Arg Gln Asp Val Phe Cys Asp Cys Ser Ile Leu Val Glu Gly 
            20                  25                  30


Lys Val Phe Lys Ala His Arg Asn Val Leu Phe Ala Ser Ser Gly Tyr 
        35                  40                  45


Phe Lys Met Leu Leu Ser Gln Asn Ser Lys Glu Thr Ser Gln Pro Thr 
    50                  55                  60


Thr Ala Thr Phe Gln Ala Phe Ser Pro Asp Thr Phe Thr Val Ile Leu 
65                  70                  75                  80


Asp Phe Val Tyr Ser Gly Lys Leu Ser Leu Thr Gly Gln Asn Val Ile 
                85                  90                  95


Glu Val Met Ser Ala Ala Ser Phe Leu Gln Met Thr Asp Val Ile Ser 
            100                 105                 110


Val Cys Lys Thr Phe Ile Lys Ser Ser Leu Asp Ile Ser Glu Lys Glu 
        115                 120                 125


Lys Asp Arg Tyr Phe Ser Leu Ser Asp Lys Asp Ala Asn Ser Asn Gly 
    130                 135                 140


Val Glu Arg Ser Ser Phe Tyr Ser Gly Gly Trp Gln Glu Gly Ser Ser 
145                 150                 155                 160


Ser Pro Arg Ser His Leu Ser Pro Glu Gln Gly Thr Gly Ile Ile Ser 
                165                 170                 175


Gly Lys Ser Trp Asn Lys Tyr Asn Tyr His Pro Ala Ser Gln Lys Asn 
            180                 185                 190


Thr Gln Gln Pro Leu Ala Lys His Glu Pro Arg Lys Glu Ser Ile Lys 
        195                 200                 205


Lys Thr Lys His Leu Arg Leu Ser Gln Pro Ser Glu Val Thr His Tyr 
    210                 215                 220


Lys Ser Ser Lys Arg Glu Val Arg Thr Ser Asp Ser Ser Ser His Val 
225                 230                 235                 240


Ser Gln Ser Glu Glu Gln Ala Gln Ile Asp Ala Glu Met Asp Ser Thr 
                245                 250                 255


Pro Val Gly Tyr Gln Tyr Gly Gln Gly Ser Asp Val Thr Ser Lys Ser 
            260                 265                 270


Phe Pro Asp Asp Leu Pro Arg Met Arg Phe Lys Cys Pro Tyr Cys Thr 
        275                 280                 285


His Val Val Lys Arg Lys Ala Asp Leu Lys Arg His Leu Arg Cys His 
    290                 295                 300


Thr Gly Glu Arg Pro Tyr Pro Cys Gln Ala Cys Gly Lys Arg Phe Ser 
305                 310                 315                 320


Arg Leu Asp His Leu Ser Ser His Phe Arg Thr Ile His Gln Ala Cys 
                325                 330                 335


Lys Leu Ile Cys Arg Lys Cys Lys Arg His Val Thr Asp Leu Thr Gly 
            340                 345                 350


Gln Val Val Gln Glu Gly Thr Arg Arg Tyr Arg Leu Cys Asn Glu Cys 
        355                 360                 365


Leu Ala Glu Phe Gly Ile Asp Ser Leu Pro Ile Asp Leu Glu Ala Glu 
    370                 375                 380


Gln His Leu Met Ser Pro Ser Asp Gly Asp Lys Asp Ser Arg Trp His 
385                 390                 395                 400


Leu Ser Glu Asp Glu Asn Arg Ser Tyr Val Glu Ile Val Glu Asp Gly 
                405                 410                 415


Ser Gly Asp Leu Val Ile Gln Gln Val Asp Asp Ser Glu Glu Glu Glu 
            420                 425                 430


Glu Lys Glu Ile Lys Pro Asn Ile Arg 
        435                 440


<210>  1591
<211>  905
<212>  DNA
<213>  Homo sapiens

<400>  1591
gaaagggggt ccttccccag ccgagaacca ggaatcttcc ctcggcccgc gcgcgcgacc     60

ggccggtgcg ccgcggcccg cggacaatcc tccaaacaca gactgtttga cttagaatct    120

tccctttttt actccattca agagcagcat tcataaattt ccagcctaga tttcctgagc    180

gtatatccag acatccataa tatactgact tcatgctcag tgagcaacat tttgatgact    240

gactttccac atcacttcct cataaggaaa ggagaatatg ttgaatggag atctcctctc    300

atcagtctca cctcctgcag caactgaacg agcagcgcag gcaagatgta ttttgtgact    360

gcagtattct agttgaaggg aaggtcttca aagcacatcg aaatgtatta ttcgctagta    420

gcggctactt taaaatgctt ctttctcaga attcaaagga gacgagtcag ccaaccacag    480

ctacatttca ggctttctcc cctgacactt ttacagttat cttggacttc gtatattctg    540

gcaaactgtc tcttactggt cagaatgtca tagaagtgat gtcggctgct agcttccttc    600

agatgactga tgtcataagt gtatgtaaga cttttattaa atcttcctta gacattagtg    660

agaaagaaaa agatcgctat ttcagtctct cagataaaga tgccaattct aatggtgtag    720

aacgttcctc tttttatagt ggtggctggc aagaaggaag cagttctcca cgttctcacc    780

taagcccaga gcaaggaaca ggtataataa gtggaaaatc ttggaataag tataattatc    840

atccagcctc ccagaagaat actcaacaac ccttggccaa gcatgaacca aggaaagagt    900

ccatt                                                                905


<210>  1592
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  1592

Met Thr Asp Phe Pro His His Phe Leu Ile Arg Lys Gly Glu Tyr Val 
1               5                   10                  15


Glu Trp Arg Ser Pro Leu Ile Ser Leu Thr Ser Cys Ser Asn 
            20                  25                  30


<210>  1593
<211>  1700
<212>  DNA
<213>  Homo sapiens

<400>  1593
tttgaaacca cgtcagtagg aagactgaat gtttcaatct tgtggattgt attacacaga     60

gcatgaatat acttctttag gttacacgca tggggagata ctctggagga agcatttgag    120

caatgtgcaa tggccatgtt tggttacatg acagatactg ggacagtgga gcccctccaa    180

acagtagaag tagaaaccca aggagatgac ttacagtctc ttctgtttca ctttttggat    240

gaatggcttt ataagttcag tgctgatgaa ttcttcatac cccgggaagt gaaagtactt    300

agcattgatc aaagaaattt caaattacga tcaattgggt ggggagaaga attttcattg    360

tccaagcacc ctcagggaac agaagtcaaa gcaataacat attcagcaat gcaggtctat    420

aatgaagaga acccggaagt ttttgtgatc attgacattt aagacaccaa aaaataaaag    480

actcctacga agaactgttt ttgttttcct cttccttttg agaagacact atgaattaaa    540

ttctacagct tttttttgat atatggaaat ttgtagaaca gaaatatttt agttaaagtg    600

tgactttcag aaagggaaaa tcagggcaca gccttggtct gtgttcccca aatattcaca    660

ctttaaagaa ttcttcaacc ccccaaggga cagttatggt cctttgattc tctgctgtgg    720

cagtaggtgt gcctcatgcc cttccagtgc aatgcaagcc ctccagcctc accccagaga    780

ggatcactga tgtcagcagc agcctgaggc tgaatccagg ttgaaagaag aataacttga    840

aaaaatatat ttccacacac agaattttgt ttttcttcca agttggttaa gacatatatt    900

ttgtttcttt tttttttttt tttttgagac ggagtctcgc tctgtagccc aggctgaagc    960

gcagtggtgt gagctcggct tactgcaagc tccacctccc gggttcacgc cattctccta   1020

cctcagcctc ccgagtagct gggactatag gcacccgcca ccatgcccgg ctaatttttg   1080

tatctttagt agagacgggg tttcactgtg ttagctagga tggtcttgat ctcctgacct   1140

tgtgatccgc ccaccttggc ctcccaaggt actgcgatta caggcatgag ctaccatgcc   1200

cggccacaag acatagattt tctatatgca catcaaggga ggtgctggtt taggttgcta   1260

taggacagag ctatcctgta ttccagttgg tttttgtaga gaaacaatta gacttctcta   1320

gatagagccc tgatttttct ctcacgcttt cagtttttta aaagcactaa tgatatttcc   1380

tgttttctca taagaaaaag tcaatactat gccttacaaa gagacctttc cttctaatat   1440

agaattttat ttgaaagtga gtacatgttt ataactagag aataaaagga gaatttttga   1500

aaaatttctt tattgttgtt tttgtttaac tacttaagct attcgtcctt ttttttgaga   1560

cagggtcttg ctctgtcccc caggctggaa tgcagtggtg caatcatagc ttactgtggc   1620

ctcgaactcc tgggctcgag cagtccttcc aactcagctt cccaaattgc tggaactaca   1680

ggaatgcacc accatacctg                                               1700


<210>  1594
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  1594

Met Ala Met Phe Gly Tyr Met Thr Asp Thr Gly Thr Val Glu Pro Leu 
1               5                   10                  15


Gln Thr Val Glu Val Glu Thr Gln Gly Asp Asp Leu Gln Ser Leu Leu 
            20                  25                  30


Phe His Phe Leu Asp Glu Trp Leu Tyr Lys Phe Ser Ala Asp Glu Phe 
        35                  40                  45


Phe Ile Pro Arg Glu Val Lys Val Leu Ser Ile Asp Gln Arg Asn Phe 
    50                  55                  60


Lys Leu Arg Ser Ile Gly Trp Gly Glu Glu Phe Ser Leu Ser Lys His 
65                  70                  75                  80


Pro Gln Gly Thr Glu Val Lys Ala Ile Thr Tyr Ser Ala Met Gln Val 
                85                  90                  95


Tyr Asn Glu Glu Asn Pro Glu Val Phe Val Ile Ile Asp Ile 
            100                 105                 110


<210>  1595
<211>  1871
<212>  DNA
<213>  Homo sapiens

<400>  1595
ctctctgtcc ccgcaaaaaa aaaaagattc caacaaagca aagcaattag ctttgttgag     60

tgaatagata gcaaaaggtg tggatggact ggcccacatt ttcttgctct ttaaagatga    120

tattcctaat aataatggac tagagttatt ttgtgtgtgt gatttgagag tcaagtttag    180

tgtcttataa gtgtttttcc ctctgtccct cagatttgga tcatacagca gatgtccagt    240

gagtatagcg ggagttcatt cctttgaaac cacgtcagta ggaagactga atgtttcaat    300

cttggttaca cgcatgggga gatactctgg aggaagcatt tgagcaatgt gcaatggcca    360

tgtttggtta catgacagat actgggacag tggagcccct ccaaacagta gaagtagaaa    420

cccaaggaga tgacttacag tctcttctgt ttcacttttt ggatgaatgg ctttataagt    480

tcagtgctga tgaattcttc ataccccggg tggggagaag aattttcatt gtccaagcac    540

cctcagggaa cagaagtcaa agcaataaca tattcagcaa tgcaggtcta taatgaagag    600

aacccggaag tttttgtgat cattgacatt taagacacca aaaaataaaa gactcctacg    660

aagaactgtt tttgttttcc tcttcctttt gagaagacac tatgaattaa attctacagc    720

ttttttttga tatatggaaa tttgtagaac agaaatattt tagttaaagt gtgactttca    780

gaaagggaaa atcagggcac agccttggtc tgtgttcccc aaatattcac actttaaaga    840

attcttcaac cccccaaggg acagttatgg tcctttgatt ctctgctgtg gcagtaggtg    900

tgcctcatgc ccttccagtg caatgcaagc cctccagcct caccccagag aggatcactg    960

atgtcagcag cagcctgagg ctgaatccag gttgaaagaa gaataacttg aaaaaatata   1020

tttccacaca cagaattttg tttttcttcc aagttggtta agacatatat tttgtttctt   1080

tttttttttt ttttttgaga cggagtctcg ctctgtagcc caggctgaag cgcagtggtg   1140

tgagctcggc ttactgcaag ctccacctcc cgggttcacg ccattctcct acctcagcct   1200

cccgagtagc tgggactata ggcacccgcc accatgcccg gctaattttt gtatctttag   1260

tagagacggg gtttcactgt gttagctagg atggtcttga tctcctgacc ttgtgatccg   1320

cccaccttgg cctcccaagg tactgcgatt acaggcatga gctaccatgc ccggccacaa   1380

gacatagatt ttctatatgc acatcaaggg aggtgctggt ttaggttgct ataggacaga   1440

gctatcctgt attccagttg gtttttgtag agaaacaatt agacttctct agatagagcc   1500

ctgatttttc tctcacgctt tcagtttttt aaaagcacta atgatatttc ctgttttctc   1560

ataagaaaaa gtcaatacta tgccttacaa agagaccttt ccttctaata tagaatttta   1620

tttgaaagtg agtacatgtt tataactaga gaataaaagg agaatttttg aaaaatttct   1680

ttattgttgt ttttgtttaa ctacttaagc tattcgtcct tttttttgag acagggtctt   1740

gctctgtccc ccaggctgga atgcagtggt gcaatcatag cttactgtgg cctcgaactc   1800

ctgggctcga gcagtccttc caactcagct tcccaaattg ctggaactac aggaatgcac   1860

caccatacct g                                                        1871


<210>  1596
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  1596

Met Phe Gln Ser Trp Leu His Ala Trp Gly Asp Thr Leu Glu Glu Ala 
1               5                   10                  15


Phe Glu Gln Cys Ala Met Ala Met Phe Gly Tyr Met Thr Asp Thr Gly 
            20                  25                  30


Thr Val Glu Pro Leu Gln Thr Val Glu Val Glu Thr Gln Gly Asp Asp 
        35                  40                  45


Leu Gln Ser Leu Leu Phe His Phe Leu Asp Glu Trp Leu Tyr Lys Phe 
    50                  55                  60


Ser Ala Asp Glu Phe Phe Ile Pro Arg Val Gly Arg Arg Ile Phe Ile 
65                  70                  75                  80


Val Gln Ala Pro Ser Gly Asn Arg Ser Gln Ser Asn Asn Ile Phe Ser 
                85                  90                  95


Asn Ala Gly Leu 
            100


<210>  1597
<211>  2251
<212>  DNA
<213>  Homo sapiens

<400>  1597
gacgggactg cgcccggtca gggtcacgtg agagaggttt ggtccgcaca ctcccgcggc     60

aagagggcag ccattttctt gaaggctatt aagcttacga ccctttcaga gtactgagat    120

gaaaaatcta gaatgccttc gggtctagtt atcaattttg ggggtgaagc gggggaaaga    180

acctcgccag tcagacccag acgggtttca ttcaaggtgc ccttcaacgt ttttccttag    240

tctttggaaa gaactagtaa tgaaggaatc gcagaagatg gggttttggc tttttaaata    300

tgcgatccaa gcggcagggt agggactaaa gtaggtcaac agccaactcc gagaaaggag    360

tgtggtcctt taagggtgtg cgccaagggg cggagtctag agcggaagta gtaactccgg    420

gccgaagtcc ggtggatgaa gggcggaagt agagtgtcta atcctgcagt catggcgcag    480

gaagaggaag atgttagaga ttacaatttg actgaagaac agaaggcgat caaggccaag    540

tatccgccag tcaataggaa gtacgagtat ttggatcata cagcagatgt ccatggattg    600

tattacacag agcatgaata tacttcttta ggttacacgc atggggagat actctggagg    660

aagcatttga gcaatgtgca atggccatgt ttggttacat gacagatact gggacagtgg    720

agcccctcca aacagtagaa gtagaaaccc aaggagatga cttacagtct cttctgtttc    780

actttttgga tgaatggctt tataagttca gtgctgatga attcttcata ccccgggaag    840

tgaaagtact tagcattgat caaagaaatt tcaaattacg atcaattggg tggggagaag    900

aattttcatt gtccaagcac cctcagggaa cagaagtcaa agcaataaca tattcagcaa    960

tgcaggtcta taatgaagag aacccggaag tttttgtgat cattgacatt taagacacca   1020

aaaaataaaa gactcctacg aagaactgtt tttgttttcc tcttcctttt gagaagacac   1080

tatgaattaa attctacagc ttttttttga tatatggaaa tttgtagaac agaaatattt   1140

tagttaaagt gtgactttca gaaagggaaa atcagggcac agccttggtc tgtgttcccc   1200

aaatattcac actttaaaga attcttcaac cccccaaggg acagttatgg tcctttgatt   1260

ctctgctgtg gcagtaggtg tgcctcatgc ccttccagtg caatgcaagc cctccagcct   1320

caccccagag aggatcactg atgtcagcag cagcctgagg ctgaatccag gttgaaagaa   1380

gaataacttg aaaaaatata tttccacaca cagaattttg tttttcttcc aagttggtta   1440

agacatatat tttgtttctt tttttttttt ttttttgaga cggagtctcg ctctgtagcc   1500

caggctgaag cgcagtggtg tgagctcggc ttactgcaag ctccacctcc cgggttcacg   1560

ccattctcct acctcagcct cccgagtagc tgggactata ggcacccgcc accatgcccg   1620

gctaattttt gtatctttag tagagacggg gtttcactgt gttagctagg atggtcttga   1680

tctcctgacc ttgtgatccg cccaccttgg cctcccaagg tactgcgatt acaggcatga   1740

gctaccatgc ccggccacaa gacatagatt ttctatatgc acatcaaggg aggtgctggt   1800

ttaggttgct ataggacaga gctatcctgt attccagttg gtttttgtag agaaacaatt   1860

agacttctct agatagagcc ctgatttttc tctcacgctt tcagtttttt aaaagcacta   1920

atgatatttc ctgttttctc ataagaaaaa gtcaatacta tgccttacaa agagaccttt   1980

ccttctaata tagaatttta tttgaaagtg agtacatgtt tataactaga gaataaaagg   2040

agaatttttg aaaaatttct ttattgttgt ttttgtttaa ctacttaagc tattcgtcct   2100

tttttttgag acagggtctt gctctgtccc ccaggctgga atgcagtggt gcaatcatag   2160

cttactgtgg cctcgaactc ctgggctcga gcagtccttc caactcagct tcccaaattg   2220

ctggaactac aggaatgcac caccatacct g                                  2251


<210>  1598
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  1598

Met Ala Met Phe Gly Tyr Met Thr Asp Thr Gly Thr Val Glu Pro Leu 
1               5                   10                  15


Gln Thr Val Glu Val Glu Thr Gln Gly Asp Asp Leu Gln Ser Leu Leu 
            20                  25                  30


Phe His Phe Leu Asp Glu Trp Leu Tyr Lys Phe Ser Ala Asp Glu Phe 
        35                  40                  45


Phe Ile Pro Arg Glu Val Lys Val Leu Ser Ile Asp Gln Arg Asn Phe 
    50                  55                  60


Lys Leu Arg Ser Ile Gly Trp Gly Glu Glu Phe Ser Leu Ser Lys His 
65                  70                  75                  80


Pro Gln Gly Thr Glu Val Lys Ala Ile Thr Tyr Ser Ala Met Gln Val 
                85                  90                  95


Tyr Asn Glu Glu Asn Pro Glu Val Phe Val Ile Ile Asp Ile 
            100                 105                 110


<210>  1599
<211>  2066
<212>  DNA
<213>  Homo sapiens

<400>  1599
gacgggactg cgcccggtca gggtcacgtg agagaggttt ggtccgcaca ctcccgcggc     60

aagagggcag ccattttctt gaaggctatt aagcttacga ccctttcaga gtactgagat    120

gaaaaatcta gaatgccttc gggtctagtt atcaattttg ggggtgaagc gggggaaaga    180

acctcgccag tcagacccag acgggtttca ttcaaggtgc ccttcaacgt ttttccttag    240

tctttggaaa gaactagtaa tgaaggaatc gcagaagatg gggttttggc tttttaaata    300

tgcgatccaa gcggcagggt agggactaaa gtaggtcaac agccaactcc gagaaaggag    360

tgtggtcctt taagggtgtg cgccaagggg cggagtctag agcggaagta gtaactccgg    420

gccgaagtcc ggtggatgaa gggcggaagt agagtgtcta atcctgcagt catggcgcag    480

gaagaggaag atgttagaga ttacaatttg actgaagaac agaaggcgat caaggccaag    540

tatccgccag tcaataggaa gtacgagtga gatgacttac agtctcttct gtttcacttt    600

ttggatgaat ggctttataa gttcagtgct gatgaattct tcataccccg ggaagtgaaa    660

gtacttagca ttgatcaaag aaatttcaaa ttacgatcaa ttgggtgggg agaagaattt    720

tcattgtcca agcaccctca gggaacagaa gtcaaagcaa taacatattc agcaatgcag    780

gtctataatg aagagaaccc ggaagttttt gtgatcattg acatttaaga caccaaaaaa    840

taaaagactc ctacgaagaa ctgtttttgt tttcctcttc cttttgagaa gacactatga    900

attaaattct acagcttttt tttgatatat ggaaatttgt agaacagaaa tattttagtt    960

aaagtgtgac tttcagaaag ggaaaatcag ggcacagcct tggtctgtgt tccccaaata   1020

ttcacacttt aaagaattct tcaacccccc aagggacagt tatggtcctt tgattctctg   1080

ctgtggcagt aggtgtgcct catgcccttc cagtgcaatg caagccctcc agcctcaccc   1140

cagagaggat cactgatgtc agcagcagcc tgaggctgaa tccaggttga aagaagaata   1200

acttgaaaaa atatatttcc acacacagaa ttttgttttt cttccaagtt ggttaagaca   1260

tatattttgt ttcttttttt tttttttttt tgagacggag tctcgctctg tagcccaggc   1320

tgaagcgcag tggtgtgagc tcggcttact gcaagctcca cctcccgggt tcacgccatt   1380

ctcctacctc agcctcccga gtagctggga ctataggcac ccgccaccat gcccggctaa   1440

tttttgtatc tttagtagag acggggtttc actgtgttag ctaggatggt cttgatctcc   1500

tgaccttgtg atccgcccac cttggcctcc caaggtactg cgattacagg catgagctac   1560

catgcccggc cacaagacat agattttcta tatgcacatc aagggaggtg ctggtttagg   1620

ttgctatagg acagagctat cctgtattcc agttggtttt tgtagagaaa caattagact   1680

tctctagata gagccctgat ttttctctca cgctttcagt tttttaaaag cactaatgat   1740

atttcctgtt ttctcataag aaaaagtcaa tactatgcct tacaaagaga cctttccttc   1800

taatatagaa ttttatttga aagtgagtac atgtttataa ctagagaata aaaggagaat   1860

ttttgaaaaa tttctttatt gttgtttttg tttaactact taagctattc gtcctttttt   1920

ttgagacagg gtcttgctct gtcccccagg ctggaatgca gtggtgcaat catagcttac   1980

tgtggcctcg aactcctggg ctcgagcagt ccttccaact cagcttccca aattgctgga   2040

actacaggaa tgcaccacca tacctg                                        2066


<210>  1600
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  1600

Met Lys Gly Gly Ser Arg Val Ser Asn Pro Ala Val Met Ala Gln Glu 
1               5                   10                  15


Glu Glu Asp Val Arg Asp Tyr Asn Leu Thr Glu Glu Gln Lys Ala Ile 
            20                  25                  30


Lys Ala Lys Tyr Pro Pro Val Asn Arg Lys Tyr Glu 
        35                  40


<210>  1601
<211>  2279
<212>  DNA
<213>  Homo sapiens

<400>  1601
gacgggactg cgcccggtca gggtcacgtg agagaggttt ggtccgcaca ctcccgcggc     60

aagagggcag ccattttctt gaaggctatt aagcttacga ccctttcaga gtactgagat    120

gaaaaatcta gaatgccttc gggtctagtt atcaattttg ggggtgaagc gggggaaaga    180

acctcgccag tcagacccag acgggtttca ttcaaggtgc ccttcaacgt ttttccttag    240

tctttggaaa gaactagtaa tgaaggaatc gcagaagatg gggttttggc tttttaaata    300

tgcgatccaa gcggcagggt agggactaaa gtaggtcaac agccaactcc gagaaaggag    360

tgtggtcctt taagggtgtg cgccaagggg cggagtctag agcggaagta gtaactccgg    420

gccgaagtcc ggtggatgaa gggcggaagt agagtgtcta atcctgcagt catggcgcag    480

gaagaggaag atgttagaga ttacaatttg actgaagaac agaaggcgat caaggccaag    540

tatccgccag tcaataggaa gtacgagtat ttggatcata cagcagatgt ccagtgagta    600

tagcgggagt tcattccttt gaaaccacgt cagtaggaag actgaatgtt tcaatcttgg    660

ttacacgcat ggggagatac tctggaggaa gcatttgagc aatgtgcaat ggccatgttt    720

ggttacatga cagatactgg gacagtggag cccctccaaa cagtagaagt agaaacccaa    780

ggagatgact tacagtctct tctgtttcac tttttggatg aatggcttta taagttcagt    840

gctgatgaat tcttcatacc ccgggaagtg aaagtactta gcattgatca aagaaatttc    900

aaattacgat caattgggtg gggagaagaa ttttcattgt ccaagcaccc tcagggaaca    960

gaagtcaaag caataacata ttcagcaatg caggtctata atgaagagaa cccggaagtt   1020

tttgtgatca ttgacattta agacaccaaa aaataaaaga ctcctacgaa gaactgtttt   1080

tgttttcctc ttccttttga gaagacacta tgaattaaat tctacagctt ttttttgata   1140

tatggaaatt tgtagaacag aaatatttta gttaaagtgt gactttcaga aagggaaaat   1200

cagggcacag ccttggtctg tgttccccaa atattcacac tttaaagaat tcttcaaccc   1260

cccaagggac agttatggtc ctttgattct ctgctgtggc agtaggtgtg cctcatgccc   1320

ttccagtgca atgcaagccc tccagcctca ccccagagag gatcactgat gtcagcagca   1380

gcctgaggct gaatccaggt tgaaagaaga ataacttgaa aaaatatatt tccacacaca   1440

gaattttgtt tttcttccaa gttggttaag acatatattt tgtttctttt tttttttttt   1500

ttttgagacg gagtctcgct ctgtagccca ggctgaagcg cagtggtgtg agctcggctt   1560

actgcaagct ccacctcccg ggttcacgcc attctcctac ctcagcctcc cgagtagctg   1620

ggactatagg cacccgccac catgcccggc taatttttgt atctttagta gagacggggt   1680

ttcactgtgt tagctaggat ggtcttgatc tcctgacctt gtgatccgcc caccttggcc   1740

tcccaaggta ctgcgattac aggcatgagc taccatgccc ggccacaaga catagatttt   1800

ctatatgcac atcaagggag gtgctggttt aggttgctat aggacagagc tatcctgtat   1860

tccagttggt ttttgtagag aaacaattag acttctctag atagagccct gatttttctc   1920

tcacgctttc agttttttaa aagcactaat gatatttcct gttttctcat aagaaaaagt   1980

caatactatg ccttacaaag agacctttcc ttctaatata gaattttatt tgaaagtgag   2040

tacatgttta taactagaga ataaaaggag aatttttgaa aaatttcttt attgttgttt   2100

ttgtttaact acttaagcta ttcgtccttt tttttgagac agggtcttgc tctgtccccc   2160

aggctggaat gcagtggtgc aatcatagct tactgtggcc tcgaactcct gggctcgagc   2220

agtccttcca actcagcttc ccaaattgct ggaactacag gaatgcacca ccatacctg    2279


<210>  1602
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  1602

Met Phe Gln Ser Trp Leu His Ala Trp Gly Asp Thr Leu Glu Glu Ala 
1               5                   10                  15


Phe Glu Gln Cys Ala Met Ala Met Phe Gly Tyr Met Thr Asp Thr Gly 
            20                  25                  30


Thr Val Glu Pro Leu Gln Thr Val Glu Val Glu Thr Gln Gly Asp Asp 
        35                  40                  45


Leu Gln Ser Leu Leu Phe His Phe Leu Asp Glu Trp Leu Tyr Lys Phe 
    50                  55                  60


Ser Ala Asp Glu Phe Phe Ile Pro Arg Glu Val Lys Val Leu Ser Ile 
65                  70                  75                  80


Asp Gln Arg Asn Phe Lys Leu Arg Ser Ile Gly Trp Gly Glu Glu Phe 
                85                  90                  95


Ser Leu Ser Lys His Pro Gln Gly Thr Glu Val Lys Ala Ile Thr Tyr 
            100                 105                 110


Ser Ala Met Gln Val Tyr Asn Glu Glu Asn Pro Glu Val Phe Val Ile 
        115                 120                 125


Ile Asp Ile 
    130


<210>  1603
<211>  2139
<212>  DNA
<213>  Homo sapiens

<400>  1603
gacgggactg cgcccggtca gggtcacgtg agagaggttt ggtccgcaca ctcccgcggc     60

aagagggcag ccattttctt gaaggctatt aagcttacga ccctttcaga gtactgagat    120

gaaaaatcta gaatgccttc gggtctagtt atcaattttg ggggtgaagc gggggaaaga    180

acctcgccag tcagacccag acgggtttca ttcaaggtgc ccttcaacgt ttttccttag    240

tctttggaaa gaactagtaa tgaaggaatc gcagaagatg gggttttggc tttttaaata    300

tgcgatccaa gcggcagggt agggactaaa gtaggtcaac agccaactcc gagaaaggag    360

tgtggtcctt taagggtgtg cgccaagggg cggagtctag agcggaagta gtaactccgg    420

gccgaagtcc ggtggatgaa gggcggaagt agagtgtcta atcctgcagt catggcgcag    480

gaagaggaag atgttagaga ttacaatttg actgaagaac agaaggcgat caaggccaag    540

tatccgccag tcaataggaa gtacgagtgt gagttacacg catggggaga tactctggag    600

gaagcatttg agcaatgtgc aatggccatg tttggttaca tgacagatac tgggacagtg    660

gagcccctcc aaacagtaga agtagaaacc caaggagatg acttacagtc tcttctgttt    720

cactttttgg atgaatggct ttataagttc agtgctgatg aattcttcat accccgggtg    780

gggagaagaa ttttcattgt ccaagcaccc tcagggaaca gaagtcaaag caataacata    840

ttcagcaatg caggtctata atgaagagaa cccggaagtt tttgtgatca ttgacattta    900

agacaccaaa aaataaaaga ctcctacgaa gaactgtttt tgttttcctc ttccttttga    960

gaagacacta tgaattaaat tctacagctt ttttttgata tatggaaatt tgtagaacag   1020

aaatatttta gttaaagtgt gactttcaga aagggaaaat cagggcacag ccttggtctg   1080

tgttccccaa atattcacac tttaaagaat tcttcaaccc cccaagggac agttatggtc   1140

ctttgattct ctgctgtggc agtaggtgtg cctcatgccc ttccagtgca atgcaagccc   1200

tccagcctca ccccagagag gatcactgat gtcagcagca gcctgaggct gaatccaggt   1260

tgaaagaaga ataacttgaa aaaatatatt tccacacaca gaattttgtt tttcttccaa   1320

gttggttaag acatatattt tgtttctttt tttttttttt ttttgagacg gagtctcgct   1380

ctgtagccca ggctgaagcg cagtggtgtg agctcggctt actgcaagct ccacctcccg   1440

ggttcacgcc attctcctac ctcagcctcc cgagtagctg ggactatagg cacccgccac   1500

catgcccggc taatttttgt atctttagta gagacggggt ttcactgtgt tagctaggat   1560

ggtcttgatc tcctgacctt gtgatccgcc caccttggcc tcccaaggta ctgcgattac   1620

aggcatgagc taccatgccc ggccacaaga catagatttt ctatatgcac atcaagggag   1680

gtgctggttt aggttgctat aggacagagc tatcctgtat tccagttggt ttttgtagag   1740

aaacaattag acttctctag atagagccct gatttttctc tcacgctttc agttttttaa   1800

aagcactaat gatatttcct gttttctcat aagaaaaagt caatactatg ccttacaaag   1860

agacctttcc ttctaatata gaattttatt tgaaagtgag tacatgttta taactagaga   1920

ataaaaggag aatttttgaa aaatttcttt attgttgttt ttgtttaact acttaagcta   1980

ttcgtccttt tttttgagac agggtcttgc tctgtccccc aggctggaat gcagtggtgc   2040

aatcatagct tactgtggcc tcgaactcct gggctcgagc agtccttcca actcagcttc   2100

ccaaattgct ggaactacag gaatgcacca ccatacctg                          2139


<210>  1604
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  1604

Met Lys Gly Gly Ser Arg Val Ser Asn Pro Ala Val Met Ala Gln Glu 
1               5                   10                  15


Glu Glu Asp Val Arg Asp Tyr Asn Leu Thr Glu Glu Gln Lys Ala Ile 
            20                  25                  30


Lys Ala Lys Tyr Pro Pro Val Asn Arg Lys Tyr Glu Cys Glu Leu His 
        35                  40                  45


Ala Trp Gly Asp Thr Leu Glu Glu Ala Phe Glu Gln Cys Ala Met Ala 
    50                  55                  60


Met Phe Gly Tyr Met Thr Asp Thr Gly Thr Val Glu Pro Leu Gln Thr 
65                  70                  75                  80


Val Glu Val Glu Thr Gln Gly Asp Asp Leu Gln Ser Leu Leu Phe His 
                85                  90                  95


Phe Leu Asp Glu Trp Leu Tyr Lys Phe Ser Ala Asp Glu Phe Phe Ile 
            100                 105                 110


Pro Arg Val Gly Arg Arg Ile Phe Ile Val Gln Ala Pro Ser Gly Asn 
        115                 120                 125


Arg Ser Gln Ser Asn Asn Ile Phe Ser Asn Ala Gly Leu 
    130                 135                 140


<210>  1605
<211>  1897
<212>  DNA
<213>  Homo sapiens

<400>  1605
gacgggactg cgcccggtca gggtcacgtg agagaggttt ggtccgcaca ctcccgcggc     60

aagagggcag ccattttctt gaaggctatt aagcttacga ccctttcaga gtactgagat    120

gaaaaatcta gaatgccttc gggtctagtt atcaattttg ggggtgaagc gggggaaaga    180

acctcgccag tcagacccag acgggtttca ttcaaggtgc ccttcaacgt ttttccttag    240

tctttggaaa gaactagtaa tgaaggaatc gcagaagatg gggttttggc tttttaaata    300

tgcgatccaa gcggcagggt agggactaaa gtaggtcaac agccaactcc gagaaaggag    360

tgtggtcctt taagggtgtg cgccaagggg cggagtctag agcggaagta gtaactccgg    420

gccgaagtcc ggtggatgaa gggcggaagt agagtgtcta atcctgcagt catggcgcag    480

gaagaggaag atgttagaga ttacaatttg actgaagaac agaaggcgat caaggccaag    540

tatccgccag tcaataggaa gtacgagtgt gaggaacaga agtcaaagca ataacatatt    600

cagcaatgca ggtctataat gaagagaacc cggaagtttt tgtgatcatt gacatttaag    660

acaccaaaaa ataaaagact cctacgaaga actgtttttg ttttcctctt ccttttgaga    720

agacactatg aattaaattc tacagctttt ttttgatata tggaaatttg tagaacagaa    780

atattttagt taaagtgtga ctttcagaaa gggaaaatca gggcacagcc ttggtctgtg    840

ttccccaaat attcacactt taaagaattc ttcaaccccc caagggacag ttatggtcct    900

ttgattctct gctgtggcag taggtgtgcc tcatgccctt ccagtgcaat gcaagccctc    960

cagcctcacc ccagagagga tcactgatgt cagcagcagc ctgaggctga atccaggttg   1020

aaagaagaat aacttgaaaa aatatatttc cacacacaga attttgtttt tcttccaagt   1080

tggttaagac atatattttg tttctttttt tttttttttt ttgagacgga gtctcgctct   1140

gtagcccagg ctgaagcgca gtggtgtgag ctcggcttac tgcaagctcc acctcccggg   1200

ttcacgccat tctcctacct cagcctcccg agtagctggg actataggca cccgccacca   1260

tgcccggcta atttttgtat ctttagtaga gacggggttt cactgtgtta gctaggatgg   1320

tcttgatctc ctgaccttgt gatccgccca ccttggcctc ccaaggtact gcgattacag   1380

gcatgagcta ccatgcccgg ccacaagaca tagattttct atatgcacat caagggaggt   1440

gctggtttag gttgctatag gacagagcta tcctgtattc cagttggttt ttgtagagaa   1500

acaattagac ttctctagat agagccctga tttttctctc acgctttcag ttttttaaaa   1560

gcactaatga tatttcctgt tttctcataa gaaaaagtca atactatgcc ttacaaagag   1620

acctttcctt ctaatataga attttatttg aaagtgagta catgtttata actagagaat   1680

aaaaggagaa tttttgaaaa atttctttat tgttgttttt gtttaactac ttaagctatt   1740

cgtccttttt tttgagacag ggtcttgctc tgtcccccag gctggaatgc agtggtgcaa   1800

tcatagctta ctgtggcctc gaactcctgg gctcgagcag tccttccaac tcagcttccc   1860

aaattgctgg aactacagga atgcaccacc atacctg                            1897


<210>  1606
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  1606

Met Lys Gly Gly Ser Arg Val Ser Asn Pro Ala Val Met Ala Gln Glu 
1               5                   10                  15


Glu Glu Asp Val Arg Asp Tyr Asn Leu Thr Glu Glu Gln Lys Ala Ile 
            20                  25                  30


Lys Ala Lys Tyr Pro Pro Val Asn Arg Lys Tyr Glu Cys Glu Glu Gln 
        35                  40                  45


Lys Ser Lys Gln 
    50


<210>  1607
<211>  1955
<212>  DNA
<213>  Homo sapiens

<400>  1607
gacgggactg cgcccggtca gggtcacgtg agagaggttt ggtccgcaca ctcccgcggc     60

aagagggcag ccattttctt gaaggctatt aagcttacga ccctttcaga gtactgagat    120

gaaaaatcta gaatgccttc gggtctagtt atcaattttg ggggtgaagc gggggaaaga    180

acctcgccag tcagacccag acgggtttca ttcaaggtgc ccttcaacgt ttttccttag    240

tctttggaaa gaactagtaa tgaaggaatc gcagaagatg gggttttggc tttttaaata    300

tgcgatccaa gcggcagggt agggactaaa gtaggtcaac agccaactcc gagaaaggag    360

tgtggtcctt taagggtgtg cgccaagggg cggagtctag agcggaagta gtaactccgg    420

gccgaagtcc ggtggatgaa gggcggaagt agagtgtcta atcctgcagt catggcgcag    480

gaagaggaag atgttagaga ttacaatttg actgaagaac agaaggcgat caaggccaag    540

tatccgccag tcaataggaa gtacgagtat ttggatcata cagcagatgt ccagtgggga    600

gaagaatttt cattgtccaa gcaccctcag ggaacagaag tcaaagcaat aacatattca    660

gcaatgcagg tctataatga agagaacccg gaagtttttg tgatcattga catttaagac    720

accaaaaaat aaaagactcc tacgaagaac tgtttttgtt ttcctcttcc ttttgagaag    780

acactatgaa ttaaattcta cagctttttt ttgatatatg gaaatttgta gaacagaaat    840

attttagtta aagtgtgact ttcagaaagg gaaaatcagg gcacagcctt ggtctgtgtt    900

ccccaaatat tcacacttta aagaattctt caacccccca agggacagtt atggtccttt    960

gattctctgc tgtggcagta ggtgtgcctc atgcccttcc agtgcaatgc aagccctcca   1020

gcctcacccc agagaggatc actgatgtca gcagcagcct gaggctgaat ccaggttgaa   1080

agaagaataa cttgaaaaaa tatatttcca cacacagaat tttgtttttc ttccaagttg   1140

gttaagacat atattttgtt tctttttttt tttttttttt gagacggagt ctcgctctgt   1200

agcccaggct gaagcgcagt ggtgtgagct cggcttactg caagctccac ctcccgggtt   1260

cacgccattc tcctacctca gcctcccgag tagctgggac tataggcacc cgccaccatg   1320

cccggctaat ttttgtatct ttagtagaga cggggtttca ctgtgttagc taggatggtc   1380

ttgatctcct gaccttgtga tccgcccacc ttggcctccc aaggtactgc gattacaggc   1440

atgagctacc atgcccggcc acaagacata gattttctat atgcacatca agggaggtgc   1500

tggtttaggt tgctatagga cagagctatc ctgtattcca gttggttttt gtagagaaac   1560

aattagactt ctctagatag agccctgatt tttctctcac gctttcagtt ttttaaaagc   1620

actaatgata tttcctgttt tctcataaga aaaagtcaat actatgcctt acaaagagac   1680

ctttccttct aatatagaat tttatttgaa agtgagtaca tgtttataac tagagaataa   1740

aaggagaatt tttgaaaaat ttctttattg ttgtttttgt ttaactactt aagctattcg   1800

tccttttttt tgagacaggg tcttgctctg tcccccaggc tggaatgcag tggtgcaatc   1860

atagcttact gtggcctcga actcctgggc tcgagcagtc cttccaactc agcttcccaa   1920

attgctggaa ctacaggaat gcaccaccat acctg                              1955


<210>  1608
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  1608

Met Lys Gly Gly Ser Arg Val Ser Asn Pro Ala Val Met Ala Gln Glu 
1               5                   10                  15


Glu Glu Asp Val Arg Asp Tyr Asn Leu Thr Glu Glu Gln Lys Ala Ile 
            20                  25                  30


Lys Ala Lys Tyr Pro Pro Val Asn Arg Lys Tyr Glu Tyr Leu Asp His 
        35                  40                  45


Thr Ala Asp Val Gln Trp Gly Glu Glu Phe Ser Leu Ser Lys His Pro 
    50                  55                  60


Gln Gly Thr Glu Val Lys Ala Ile Thr Tyr Ser Ala Met Gln Val Tyr 
65                  70                  75                  80


Asn Glu Glu Asn Pro Glu Val Phe Val Ile Ile Asp Ile 
                85                  90


<210>  1609
<211>  2205
<212>  DNA
<213>  Homo sapiens

<400>  1609
gcgcgccggc gttgacggga ctgcgcccgg tcagggtcac gtgagagagg tttggtccgc     60

acactcccgc ggcaagaggg cagccatttt cttgaaggct attaagctta cgaccctttc    120

agagtactga gatgaaaaat ctagaatgcc ttcgggtcta gttatcaatt ttgggggtga    180

agcgggggaa agaacctcgc cagtcagacc cagacgggtt tcattcaagg tgcccttcaa    240

cgtttttcct tagtctttgg aaagaactag taatgaagga atcgcagaag atggggtttt    300

ggctttttaa atatgcgatc caagcggcag ggtagggact aaagtaggtc aacagccaac    360

tccgagaaag gagtgtggtc ctttaagggt gtgcgccaag gggcggagtc tagagcggaa    420

gtagtaactc cgggccgaag tccggtggat gaagggcgga agtagagtgt ctaatcctgc    480

agtcatggcg caggaagagg aagatgttag agattacaat ttgactgaag aacagaaggc    540

gatcaaggcc aagtatccgc cagtcaatag gaagtacgag tgtgagttac acgcatgggg    600

agatactctg gaggaagcat ttgagcaatg tgcaatggcc atgtttggtt acatgacaga    660

tactgggaca gtggagcccc tccaaacagt agaagtagaa acccaaggag atgacttaca    720

gtctcttctg tttcactttt tggatgaatg gctttataag ttcagtgctg atgaattctt    780

cataccccgg gaagtgaaag tacttagcat tgatcaaaga aatttcaaat tacgatcaat    840

tgggtgggga gaagaatttt cattgtccaa gcaccctcag ggaacagaag tcaaagcaat    900

aacatattca gcaatgcagg tctataatga agagaacccg gaagtttttg tgatcattga    960

catttaagac accaaaaaat aaaagactcc tacgaagaac tgtttttgtt ttcctcttcc   1020

ttttgagaag acactatgaa ttaaattcta cagctttttt ttgatatatg gaaatttgta   1080

gaacagaaat attttagtta aagtgtgact ttcagaaagg gaaaatcagg gcacagcctt   1140

ggtctgtgtt ccccaaatat tcacacttta aagaattctt caacccccca agggacagtt   1200

atggtccttt gattctctgc tgtggcagta ggtgtgcctc atgcccttcc agtgcaatgc   1260

aagccctcca gcctcacccc agagaggatc actgatgtca gcagcagcct gaggctgaat   1320

ccaggttgaa agaagaataa cttgaaaaaa tatatttcca cacacagaat tttgtttttc   1380

ttccaagttg gttaagacat atattttgtt tctttttttt tttttttttt gagacggagt   1440

ctcgctctgt agcccaggct gaagcgcagt ggtgtgagct cggcttactg caagctccac   1500

ctcccgggtt cacgccattc tcctacctca gcctcccgag tagctgggac tataggcacc   1560

cgccaccatg cccggctaat ttttgtatct ttagtagaga cggggtttca ctgtgttagc   1620

taggatggtc ttgatctcct gaccttgtga tccgcccacc ttggcctccc aaggtactgc   1680

gattacaggc atgagctacc atgcccggcc acaagacata gattttctat atgcacatca   1740

agggaggtgc tggtttaggt tgctatagga cagagctatc ctgtattcca gttggttttt   1800

gtagagaaac aattagactt ctctagatag agccctgatt tttctctcac gctttcagtt   1860

ttttaaaagc actaatgata tttcctgttt tctcataaga aaaagtcaat actatgcctt   1920

acaaagagac ctttccttct aatatagaat tttatttgaa agtgagtaca tgtttataac   1980

tagagaataa aaggagaatt tttgaaaaat ttctttattg ttgtttttgt ttaactactt   2040

aagctattcg tccttttttt tgagacaggg tcttgctctg tcccccaggc tggaatgcag   2100

tggtgcaatc atagcttact gtggcctcga actcctgggc tcgagcagtc cttccaactc   2160

agcttcccaa attgctggaa ctacaggaat gcaccaccat acctg                   2205


<210>  1610
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  1610

Met Lys Gly Gly Ser Arg Val Ser Asn Pro Ala Val Met Ala Gln Glu 
1               5                   10                  15


Glu Glu Asp Val Arg Asp Tyr Asn Leu Thr Glu Glu Gln Lys Ala Ile 
            20                  25                  30


Lys Ala Lys Tyr Pro Pro Val Asn Arg Lys Tyr Glu Cys Glu Leu His 
        35                  40                  45


Ala Trp Gly Asp Thr Leu Glu Glu Ala Phe Glu Gln Cys Ala Met Ala 
    50                  55                  60


Met Phe Gly Tyr Met Thr Asp Thr Gly Thr Val Glu Pro Leu Gln Thr 
65                  70                  75                  80


Val Glu Val Glu Thr Gln Gly Asp Asp Leu Gln Ser Leu Leu Phe His 
                85                  90                  95


Phe Leu Asp Glu Trp Leu Tyr Lys Phe Ser Ala Asp Glu Phe Phe Ile 
            100                 105                 110


Pro Arg Glu Val Lys Val Leu Ser Ile Asp Gln Arg Asn Phe Lys Leu 
        115                 120                 125


Arg Ser Ile Gly Trp Gly Glu Glu Phe Ser Leu Ser Lys His Pro Gln 
    130                 135                 140


Gly Thr Glu Val Lys Ala Ile Thr Tyr Ser Ala Met Gln Val Tyr Asn 
145                 150                 155                 160


Glu Glu Asn Pro Glu Val Phe Val Ile Ile Asp Ile 
                165                 170


<210>  1611
<211>  2239
<212>  DNA
<213>  Homo sapiens

<400>  1611
gcgcgccggc gttgacggga ctgcgcccgg tcagggtcac gtgagagagg tttggtccgc     60

acactcccgc ggcaagaggg cagccatttt cttgaaggct attaagctta cgaccctttc    120

agagtactga gatgaaaaat ctagaatgcc ttcgggtcta gttatcaatt ttgggggtga    180

agcgggggaa agaacctcgc cagtcagacc cagacgggtt tcattcaagg tgcccttcaa    240

cgtttttcct tagtctttgg aaagaactag taatgaagga atcgcagaag atggggtttt    300

ggctttttaa atatgcgatc caagcggcag ggtagggact aaagtaggtc aacagccaac    360

tccgagaaag gagtgtggtc ctttaagggt gtgcgccaag gggcggagtc tagagcggaa    420

gtagtaactc cgggccgaag tccggtggat gaagggcgga agtagagtgt ctaatcctgc    480

agtcatggcg caggaagagg aagatgttag agattacaat ttgactgaag aacagaaggc    540

gatcaaggcc aagtatccgc cagtcaatag gaagtacgag ttggattgta ttacacagag    600

catgaatata cttctttagg ttacacgcat ggggagatac tctggaggaa gcatttgagc    660

aatgtgcaat ggccatgttt ggttacatga cagatactgg gacagtggag cccctccaaa    720

cagtagaagt agaaacccaa ggagatgact tacagtctct tctgtttcac tttttggatg    780

aatggcttta taagttcagt gctgatgaat tcttcatacc ccgggaagtg aaagtactta    840

gcattgatca aagaaatttc aaattacgat caattgggtg gggagaagaa ttttcattgt    900

ccaagcaccc tcagggaaca gaagtcaaag caataacata ttcagcaatg caggtctata    960

atgaagagaa cccggaagtt tttgtgatca ttgacattta agacaccaaa aaataaaaga   1020

ctcctacgaa gaactgtttt tgttttcctc ttccttttga gaagacacta tgaattaaat   1080

tctacagctt ttttttgata tatggaaatt tgtagaacag aaatatttta gttaaagtgt   1140

gactttcaga aagggaaaat cagggcacag ccttggtctg tgttccccaa atattcacac   1200

tttaaagaat tcttcaaccc cccaagggac agttatggtc ctttgattct ctgctgtggc   1260

agtaggtgtg cctcatgccc ttccagtgca atgcaagccc tccagcctca ccccagagag   1320

gatcactgat gtcagcagca gcctgaggct gaatccaggt tgaaagaaga ataacttgaa   1380

aaaatatatt tccacacaca gaattttgtt tttcttccaa gttggttaag acatatattt   1440

tgtttctttt tttttttttt ttttgagacg gagtctcgct ctgtagccca ggctgaagcg   1500

cagtggtgtg agctcggctt actgcaagct ccacctcccg ggttcacgcc attctcctac   1560

ctcagcctcc cgagtagctg ggactatagg cacccgccac catgcccggc taatttttgt   1620

atctttagta gagacggggt ttcactgtgt tagctaggat ggtcttgatc tcctgacctt   1680

gtgatccgcc caccttggcc tcccaaggta ctgcgattac aggcatgagc taccatgccc   1740

ggccacaaga catagatttt ctatatgcac atcaagggag gtgctggttt aggttgctat   1800

aggacagagc tatcctgtat tccagttggt ttttgtagag aaacaattag acttctctag   1860

atagagccct gatttttctc tcacgctttc agttttttaa aagcactaat gatatttcct   1920

gttttctcat aagaaaaagt caatactatg ccttacaaag agacctttcc ttctaatata   1980

gaattttatt tgaaagtgag tacatgttta taactagaga ataaaaggag aatttttgaa   2040

aaatttcttt attgttgttt ttgtttaact acttaagcta ttcgtccttt tttttgagac   2100

agggtcttgc tctgtccccc aggctggaat gcagtggtgc aatcatagct tactgtggcc   2160

tcgaactcct gggctcgagc agtccttcca actcagcttc ccaaattgct ggaactacag   2220

gaatgcacca ccatacctg                                                2239


<210>  1612
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  1612

Met Ala Met Phe Gly Tyr Met Thr Asp Thr Gly Thr Val Glu Pro Leu 
1               5                   10                  15


Gln Thr Val Glu Val Glu Thr Gln Gly Asp Asp Leu Gln Ser Leu Leu 
            20                  25                  30


Phe His Phe Leu Asp Glu Trp Leu Tyr Lys Phe Ser Ala Asp Glu Phe 
        35                  40                  45


Phe Ile Pro Arg Glu Val Lys Val Leu Ser Ile Asp Gln Arg Asn Phe 
    50                  55                  60


Lys Leu Arg Ser Ile Gly Trp Gly Glu Glu Phe Ser Leu Ser Lys His 
65                  70                  75                  80


Pro Gln Gly Thr Glu Val Lys Ala Ile Thr Tyr Ser Ala Met Gln Val 
                85                  90                  95


Tyr Asn Glu Glu Asn Pro Glu Val Phe Val Ile Ile Asp Ile 
            100                 105                 110


<210>  1613
<211>  2186
<212>  DNA
<213>  Homo sapiens

<400>  1613
gcgcgccggc gttgacggga ctgcgcccgg tcagggtcac gtgagagagg tttggtccgc     60

acactcccgc ggcaagaggg cagccatttt cttgaaggct attaagctta cgaccctttc    120

agagtactga gatgaaaaat ctagaatgcc ttcgggtcta gttatcaatt ttgggggtga    180

agcgggggaa agaacctcgc cagtcagacc cagacgggtt tcattcaagg tgcccttcaa    240

cgtttttcct tagtctttgg aaagaactag taatgaagga atcgcagaag atggggtttt    300

ggctttttaa atatgcgatc caagcggcag ggtagggact aaagtaggtc aacagccaac    360

tccgagaaag gagtgtggtc ctttaagggt gtgcgccaag gggcggagtc tagagcggaa    420

gtagtaactc cgggccgaag tccggtggat gaagggcgga agtagagtgt ctaatcctgc    480

agtcatggcg caggaagagg aagatgttag agattacaat ttgactgaag aacagaaggc    540

gatcaaggcc aagtatccgc cagtcaatag gaagtacgag ttggattgta ttacacagag    600

catgaatata cttctttagg ttacacgcat ggggagatac tctggaggaa gcatttgagc    660

aatgtgcaat ggccatgttt ggttacatga cagatactgg gacagtggag cccctccaaa    720

cagtagaagt agaaacccaa ggagatgact tacagtctct tctgtttcac tttttggatg    780

aatggcttta taagttcagt gctgatgaat tcttcatacc ccgggtgggg agaagaattt    840

tcattgtcca agcaccctca gggaacagaa gtcaaagcaa taacatattc agcaatgcag    900

gtctataatg aagagaaccc ggaagttttt gtgatcattg acatttaaga caccaaaaaa    960

taaaagactc ctacgaagaa ctgtttttgt tttcctcttc cttttgagaa gacactatga   1020

attaaattct acagcttttt tttgatatat ggaaatttgt agaacagaaa tattttagtt   1080

aaagtgtgac tttcagaaag ggaaaatcag ggcacagcct tggtctgtgt tccccaaata   1140

ttcacacttt aaagaattct tcaacccccc aagggacagt tatggtcctt tgattctctg   1200

ctgtggcagt aggtgtgcct catgcccttc cagtgcaatg caagccctcc agcctcaccc   1260

cagagaggat cactgatgtc agcagcagcc tgaggctgaa tccaggttga aagaagaata   1320

acttgaaaaa atatatttcc acacacagaa ttttgttttt cttccaagtt ggttaagaca   1380

tatattttgt ttcttttttt tttttttttt tgagacggag tctcgctctg tagcccaggc   1440

tgaagcgcag tggtgtgagc tcggcttact gcaagctcca cctcccgggt tcacgccatt   1500

ctcctacctc agcctcccga gtagctggga ctataggcac ccgccaccat gcccggctaa   1560

tttttgtatc tttagtagag acggggtttc actgtgttag ctaggatggt cttgatctcc   1620

tgaccttgtg atccgcccac cttggcctcc caaggtactg cgattacagg catgagctac   1680

catgcccggc cacaagacat agattttcta tatgcacatc aagggaggtg ctggtttagg   1740

ttgctatagg acagagctat cctgtattcc agttggtttt tgtagagaaa caattagact   1800

tctctagata gagccctgat ttttctctca cgctttcagt tttttaaaag cactaatgat   1860

atttcctgtt ttctcataag aaaaagtcaa tactatgcct tacaaagaga cctttccttc   1920

taatatagaa ttttatttga aagtgagtac atgtttataa ctagagaata aaaggagaat   1980

ttttgaaaaa tttctttatt gttgtttttg tttaactact taagctattc gtcctttttt   2040

ttgagacagg gtcttgctct gtcccccagg ctggaatgca gtggtgcaat catagcttac   2100

tgtggcctcg aactcctggg ctcgagcagt ccttccaact cagcttccca aattgctgga   2160

actacaggaa tgcaccacca tacctg                                        2186


<210>  1614
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  1614

Met Ala Met Phe Gly Tyr Met Thr Asp Thr Gly Thr Val Glu Pro Leu 
1               5                   10                  15


Gln Thr Val Glu Val Glu Thr Gln Gly Asp Asp Leu Gln Ser Leu Leu 
            20                  25                  30


Phe His Phe Leu Asp Glu Trp Leu Tyr Lys Phe Ser Ala Asp Glu Phe 
        35                  40                  45


Phe Ile Pro Arg Val Gly Arg Arg Ile Phe Ile Val Gln Ala Pro Ser 
    50                  55                  60


Gly Asn Arg Ser Gln Ser Asn Asn Ile Phe Ser Asn Ala Gly Leu 
65                  70                  75


<210>  1615
<211>  1943
<212>  DNA
<213>  Homo sapiens

<400>  1615
gcgcgccggc gttgacggga ctgcgcccgg tcagggtcac gtgagagagg tttggtccgc     60

acactcccgc ggcaagaggg cagccatttt cttgaaggct attaagctta cgaccctttc    120

agagtactga gatgaaaaat ctagaatgcc ttcgggtcta gttatcaatt ttgggggtga    180

agcgggggaa agaacctcgc cagtcagacc cagacgggtt tcattcaagg tgcccttcaa    240

cgtttttcct tagtctttgg aaagaactag taatgaagga atcgcagaag atggggtttt    300

ggctttttaa atatgcgatc caagcggcag ggtagggact aaagtaggtc aacagccaac    360

tccgagaaag gagtgtggtc ctttaagggt gtgcgccaag gggcggagtc tagagcggaa    420

gtagtaactc cgggccgaag tccggtggat gaagggcgga agtagagtgt ctaatcctgc    480

agtcatggcg caggaagagg aagatgttag agattacaat ttgactgaag aacagaaggc    540

gatcaaggcc aagtatccgc cagtcaatag gaagtacgag tgtggggaga agaattttca    600

ttgtccaagc accctcaggg aacagaagtc aaagcaataa catattcagc aatgcaggtc    660

tataatgaag agaacccgga agtttttgtg atcattgaca tttaagacac caaaaaataa    720

aagactccta cgaagaactg tttttgtttt cctcttcctt ttgagaagac actatgaatt    780

aaattctaca gctttttttt gatatatgga aatttgtaga acagaaatat tttagttaaa    840

gtgtgacttt cagaaaggga aaatcagggc acagccttgg tctgtgttcc ccaaatattc    900

acactttaaa gaattcttca accccccaag ggacagttat ggtcctttga ttctctgctg    960

tggcagtagg tgtgcctcat gcccttccag tgcaatgcaa gccctccagc ctcaccccag   1020

agaggatcac tgatgtcagc agcagcctga ggctgaatcc aggttgaaag aagaataact   1080

tgaaaaaata tatttccaca cacagaattt tgtttttctt ccaagttggt taagacatat   1140

attttgtttc tttttttttt ttttttttga gacggagtct cgctctgtag cccaggctga   1200

agcgcagtgg tgtgagctcg gcttactgca agctccacct cccgggttca cgccattctc   1260

ctacctcagc ctcccgagta gctgggacta taggcacccg ccaccatgcc cggctaattt   1320

ttgtatcttt agtagagacg gggtttcact gtgttagcta ggatggtctt gatctcctga   1380

ccttgtgatc cgcccacctt ggcctcccaa ggtactgcga ttacaggcat gagctaccat   1440

gcccggccac aagacataga ttttctatat gcacatcaag ggaggtgctg gtttaggttg   1500

ctataggaca gagctatcct gtattccagt tggtttttgt agagaaacaa ttagacttct   1560

ctagatagag ccctgatttt tctctcacgc tttcagtttt ttaaaagcac taatgatatt   1620

tcctgttttc tcataagaaa aagtcaatac tatgccttac aaagagacct ttccttctaa   1680

tatagaattt tatttgaaag tgagtacatg tttataacta gagaataaaa ggagaatttt   1740

tgaaaaattt ctttattgtt gtttttgttt aactacttaa gctattcgtc cttttttttg   1800

agacagggtc ttgctctgtc ccccaggctg gaatgcagtg gtgcaatcat agcttactgt   1860

ggcctcgaac tcctgggctc gagcagtcct tccaactcag cttcccaaat tgctggaact   1920

acaggaatgc accaccatac ctg                                           1943


<210>  1616
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  1616

Met Lys Gly Gly Ser Arg Val Ser Asn Pro Ala Val Met Ala Gln Glu 
1               5                   10                  15


Glu Glu Asp Val Arg Asp Tyr Asn Leu Thr Glu Glu Gln Lys Ala Ile 
            20                  25                  30


Lys Ala Lys Tyr Pro Pro Val Asn Arg Lys Tyr Glu Cys Gly Glu Lys 
        35                  40                  45


Asn Phe His Cys Pro Ser Thr Leu Arg Glu Gln Lys Ser Lys Gln 
    50                  55                  60


<210>  1617
<211>  2173
<212>  DNA
<213>  Homo sapiens

<400>  1617
gcgcgccggc gttgacggga ctgcgcccgg tcagggtcac gtgagagagg tttggtccgc     60

acactcccgc ggcaagaggg cagccatttt cttgaaggct attaagctta cgaccctttc    120

agagtactga gatgaaaaat ctagaatgcc ttcgggtcta gttatcaatt ttgggggtga    180

agcgggggaa agaacctcgc cagtcagacc cagacgggtt tcattcaagg tgcccttcaa    240

cgtttttcct tagtctttgg aaagaactag taatgaagga atcgcagaag atggggtttt    300

ggctttttaa atatgcgatc caagcggcag ggtagggact aaagtaggtc aacagccaac    360

tccgagaaag gagtgtggtc ctttaagggt gtgcgccaag gggcggagtc tagagcggaa    420

gtagtaactc cgggccgaag tccggtggat gaagggcgga agtagagtgt ctaatcctgc    480

agtcatggcg caggaagagg aagatgttag agattacaat ttgactgaag aacagaaggc    540

gatcaaggcc aagtatccgc cagtcaatag gaagtacgag tatttggatc atacagcaga    600

tgtccagtta cacgcatggg gagatactct ggaggaagca tttgagcaat gtgcaatggc    660

catgtttggt tacatgacag atactgggac agtggagccc ctccaaacag tagaagtaga    720

aacccaagga gatgacttac agtctcttct gtttcacttt ttggatgaat ggctttataa    780

gttcagtgct gatgaattct tcataccccg ggtggggaga agaattttca ttgtccaagc    840

accctcaggg aacagaagtc aaagcaataa catattcagc aatgcaggtc tataatgaag    900

agaacccgga agtttttgtg atcattgaca tttaagacac caaaaaataa aagactccta    960

cgaagaactg tttttgtttt cctcttcctt ttgagaagac actatgaatt aaattctaca   1020

gctttttttt gatatatgga aatttgtaga acagaaatat tttagttaaa gtgtgacttt   1080

cagaaaggga aaatcagggc acagccttgg tctgtgttcc ccaaatattc acactttaaa   1140

gaattcttca accccccaag ggacagttat ggtcctttga ttctctgctg tggcagtagg   1200

tgtgcctcat gcccttccag tgcaatgcaa gccctccagc ctcaccccag agaggatcac   1260

tgatgtcagc agcagcctga ggctgaatcc aggttgaaag aagaataact tgaaaaaata   1320

tatttccaca cacagaattt tgtttttctt ccaagttggt taagacatat attttgtttc   1380

tttttttttt ttttttttga gacggagtct cgctctgtag cccaggctga agcgcagtgg   1440

tgtgagctcg gcttactgca agctccacct cccgggttca cgccattctc ctacctcagc   1500

ctcccgagta gctgggacta taggcacccg ccaccatgcc cggctaattt ttgtatcttt   1560

agtagagacg gggtttcact gtgttagcta ggatggtctt gatctcctga ccttgtgatc   1620

cgcccacctt ggcctcccaa ggtactgcga ttacaggcat gagctaccat gcccggccac   1680

aagacataga ttttctatat gcacatcaag ggaggtgctg gtttaggttg ctataggaca   1740

gagctatcct gtattccagt tggtttttgt agagaaacaa ttagacttct ctagatagag   1800

ccctgatttt tctctcacgc tttcagtttt ttaaaagcac taatgatatt tcctgttttc   1860

tcataagaaa aagtcaatac tatgccttac aaagagacct ttccttctaa tatagaattt   1920

tatttgaaag tgagtacatg tttataacta gagaataaaa ggagaatttt tgaaaaattt   1980

ctttattgtt gtttttgttt aactacttaa gctattcgtc cttttttttg agacagggtc   2040

ttgctctgtc ccccaggctg gaatgcagtg gtgcaatcat agcttactgt ggcctcgaac   2100

tcctgggctc gagcagtcct tccaactcag cttcccaaat tgctggaact acaggaatgc   2160

accaccatac ctg                                                      2173


<210>  1618
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  1618

Met Lys Gly Gly Ser Arg Val Ser Asn Pro Ala Val Met Ala Gln Glu 
1               5                   10                  15


Glu Glu Asp Val Arg Asp Tyr Asn Leu Thr Glu Glu Gln Lys Ala Ile 
            20                  25                  30


Lys Ala Lys Tyr Pro Pro Val Asn Arg Lys Tyr Glu Tyr Leu Asp His 
        35                  40                  45


Thr Ala Asp Val Gln Leu His Ala Trp Gly Asp Thr Leu Glu Glu Ala 
    50                  55                  60


Phe Glu Gln Cys Ala Met Ala Met Phe Gly Tyr Met Thr Asp Thr Gly 
65                  70                  75                  80


Thr Val Glu Pro Leu Gln Thr Val Glu Val Glu Thr Gln Gly Asp Asp 
                85                  90                  95


Leu Gln Ser Leu Leu Phe His Phe Leu Asp Glu Trp Leu Tyr Lys Phe 
            100                 105                 110


Ser Ala Asp Glu Phe Phe Ile Pro Arg Val Gly Arg Arg Ile Phe Ile 
        115                 120                 125


Val Gln Ala Pro Ser Gly Asn Arg Ser Gln Ser Asn Asn Ile Phe Ser 
    130                 135                 140


Asn Ala Gly Leu 
145


<210>  1619
<211>  2226
<212>  DNA
<213>  Homo sapiens

<400>  1619
gcgcgccggc gttgacggga ctgcgcccgg tcagggtcac gtgagagagg tttggtccgc     60

acactcccgc ggcaagaggg cagccatttt cttgaaggct attaagctta cgaccctttc    120

agagtactga gatgaaaaat ctagaatgcc ttcgggtcta gttatcaatt ttgggggtga    180

agcgggggaa agaacctcgc cagtcagacc cagacgggtt tcattcaagg tgcccttcaa    240

cgtttttcct tagtctttgg aaagaactag taatgaagga atcgcagaag atggggtttt    300

ggctttttaa atatgcgatc caagcggcag ggtagggact aaagtaggtc aacagccaac    360

tccgagaaag gagtgtggtc ctttaagggt gtgcgccaag gggcggagtc tagagcggaa    420

gtagtaactc cgggccgaag tccggtggat gaagggcgga agtagagtgt ctaatcctgc    480

agtcatggcg caggaagagg aagatgttag agattacaat ttgactgaag aacagaaggc    540

gatcaaggcc aagtatccgc cagtcaatag gaagtacgag tatttggatc atacagcaga    600

tgtccagtta cacgcatggg gagatactct ggaggaagca tttgagcaat gtgcaatggc    660

catgtttggt tacatgacag atactgggac agtggagccc ctccaaacag tagaagtaga    720

aacccaagga gatgacttac agtctcttct gtttcacttt ttggatgaat ggctttataa    780

gttcagtgct gatgaattct tcataccccg ggaagtgaaa gtacttagca ttgatcaaag    840

aaatttcaaa ttacgatcaa ttgggtgggg agaagaattt tcattgtcca agcaccctca    900

gggaacagaa gtcaaagcaa taacatattc agcaatgcag gtctataatg aagagaaccc    960

ggaagttttt gtgatcattg acatttaaga caccaaaaaa taaaagactc ctacgaagaa   1020

ctgtttttgt tttcctcttc cttttgagaa gacactatga attaaattct acagcttttt   1080

tttgatatat ggaaatttgt agaacagaaa tattttagtt aaagtgtgac tttcagaaag   1140

ggaaaatcag ggcacagcct tggtctgtgt tccccaaata ttcacacttt aaagaattct   1200

tcaacccccc aagggacagt tatggtcctt tgattctctg ctgtggcagt aggtgtgcct   1260

catgcccttc cagtgcaatg caagccctcc agcctcaccc cagagaggat cactgatgtc   1320

agcagcagcc tgaggctgaa tccaggttga aagaagaata acttgaaaaa atatatttcc   1380

acacacagaa ttttgttttt cttccaagtt ggttaagaca tatattttgt ttcttttttt   1440

tttttttttt tgagacggag tctcgctctg tagcccaggc tgaagcgcag tggtgtgagc   1500

tcggcttact gcaagctcca cctcccgggt tcacgccatt ctcctacctc agcctcccga   1560

gtagctggga ctataggcac ccgccaccat gcccggctaa tttttgtatc tttagtagag   1620

acggggtttc actgtgttag ctaggatggt cttgatctcc tgaccttgtg atccgcccac   1680

cttggcctcc caaggtactg cgattacagg catgagctac catgcccggc cacaagacat   1740

agattttcta tatgcacatc aagggaggtg ctggtttagg ttgctatagg acagagctat   1800

cctgtattcc agttggtttt tgtagagaaa caattagact tctctagata gagccctgat   1860

ttttctctca cgctttcagt tttttaaaag cactaatgat atttcctgtt ttctcataag   1920

aaaaagtcaa tactatgcct tacaaagaga cctttccttc taatatagaa ttttatttga   1980

aagtgagtac atgtttataa ctagagaata aaaggagaat ttttgaaaaa tttctttatt   2040

gttgtttttg tttaactact taagctattc gtcctttttt ttgagacagg gtcttgctct   2100

gtcccccagg ctggaatgca gtggtgcaat catagcttac tgtggcctcg aactcctggg   2160

ctcgagcagt ccttccaact cagcttccca aattgctgga actacaggaa tgcaccacca   2220

tacctg                                                              2226


<210>  1620
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  1620

Met Lys Gly Gly Ser Arg Val Ser Asn Pro Ala Val Met Ala Gln Glu 
1               5                   10                  15


Glu Glu Asp Val Arg Asp Tyr Asn Leu Thr Glu Glu Gln Lys Ala Ile 
            20                  25                  30


Lys Ala Lys Tyr Pro Pro Val Asn Arg Lys Tyr Glu Tyr Leu Asp His 
        35                  40                  45


Thr Ala Asp Val Gln Leu His Ala Trp Gly Asp Thr Leu Glu Glu Ala 
    50                  55                  60


Phe Glu Gln Cys Ala Met Ala Met Phe Gly Tyr Met Thr Asp Thr Gly 
65                  70                  75                  80


Thr Val Glu Pro Leu Gln Thr Val Glu Val Glu Thr Gln Gly Asp Asp 
                85                  90                  95


Leu Gln Ser Leu Leu Phe His Phe Leu Asp Glu Trp Leu Tyr Lys Phe 
            100                 105                 110


Ser Ala Asp Glu Phe Phe Ile Pro Arg Glu Val Lys Val Leu Ser Ile 
        115                 120                 125


Asp Gln Arg Asn Phe Lys Leu Arg Ser Ile Gly Trp Gly Glu Glu Phe 
    130                 135                 140


Ser Leu Ser Lys His Pro Gln Gly Thr Glu Val Lys Ala Ile Thr Tyr 
145                 150                 155                 160


Ser Ala Met Gln Val Tyr Asn Glu Glu Asn Pro Glu Val Phe Val Ile 
                165                 170                 175


Ile Asp Ile 



<210>  1621
<211>  1507
<212>  DNA
<213>  Homo sapiens

<400>  1621
tttgaaacca cgtcagtagg aagactgaat gtttcaatct tgtggattgt attacacaga     60

gcatgaatat acttctttag gttacacgca tggggagata ctctggagga agcatttgag    120

caatgtgcaa tggccatgtt tggttacatg acagatactg ggacagtgga gcccctccaa    180

acagtagaag tagaaaccca aggagatgac ttacagtctc ttctgtttca ctttttggat    240

gaatggcttt ataagttcag tgctgatgaa ttcttcatac cccgggaagt gaaagtactt    300

agcattgatc aaagaaattt caaattacga tcaattgggt ggggagaaga attttcattg    360

tccaagcacc ctcagggaac agaagtcaaa gcaataacat attcagcaat gcaggtctat    420

aatgaagaga acccggaagt ttttgtgatc attgacattt aagacaccaa aaaataaaag    480

actcctacga agaactgttt ttgttttcct cttccttttg agaagacact atgaattaaa    540

ttctacagct tttttttgat atatggaaat ttgtagaaca gaaatatttt agttaaagtg    600

tgactttcag aaagggaaaa tcagggcaca gccttggtct gtgttcccca aatattcaca    660

ctttaaagaa ttcttcaacc ccccaaggga cagttatggt cctttgattc tctgctgtgg    720

cagtaggtgt gcctcatgcc cttccagtgc aatgcaagcc ctccagcctc accccagaga    780

ggatcactga tgtcagcagc agcctgaggc tgaatccagg ttgaaagaag aataacttga    840

aaaaatatat ttccacacac agaattttgt ttttcttcca agttggttaa gacatatatt    900

ttgtttcttt tttttttttt tttttgagac ggagtctcgc tctgtagccc aggctgaagc    960

gcagtggtgt gagctcggct tactgcaagc tccacctccc gggttcacgc cattctccta   1020

cctcagcctc ccgagtagct gggactatag gcacccgcca ccatgcccgg ctaatttttg   1080

tatctttagt agagacgggg tttcactgtg ttagctagga tggtcttgat ctcctgacct   1140

tgtgatccgc ccaccttggc ctcccaaggt actgcgatta caggcatgag ctaccatgcc   1200

cggccacaag acatagattt tctatatgca catcaaggga ggtgctggtt taggttgcta   1260

taggacagag ctatcctgta ttccagttgg tttttgtaga gaaacaatta gacttctcta   1320

gatagagccc tgatttttct ctcacgcttt cagtttttta aaagcactaa tgatatttcc   1380

tgttttctca taagaaaaag tcaatactat gccttacaaa gagacctttc cttctaatat   1440

agaattttat ttgaaagtga gtacatgttt ataactagag aataaaagga gaatttttga   1500

aaaattt                                                             1507


<210>  1622
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  1622

Met Ala Met Phe Gly Tyr Met Thr Asp Thr Gly Thr Val Glu Pro Leu 
1               5                   10                  15


Gln Thr Val Glu Val Glu Thr Gln Gly Asp Asp Leu Gln Ser Leu Leu 
            20                  25                  30


Phe His Phe Leu Asp Glu Trp Leu Tyr Lys Phe Ser Ala Asp Glu Phe 
        35                  40                  45


Phe Ile Pro Arg Glu Val Lys Val Leu Ser Ile Asp Gln Arg Asn Phe 
    50                  55                  60


Lys Leu Arg Ser Ile Gly Trp Gly Glu Glu Phe Ser Leu Ser Lys His 
65                  70                  75                  80


Pro Gln Gly Thr Glu Val Lys Ala Ile Thr Tyr Ser Ala Met Gln Val 
                85                  90                  95


Tyr Asn Glu Glu Asn Pro Glu Val Phe Val Ile Ile Asp Ile 
            100                 105                 110


<210>  1623
<211>  1678
<212>  DNA
<213>  Homo sapiens

<400>  1623
ctctctgtcc ccgcaaaaaa aaaaagattc caacaaagca aagcaattag ctttgttgag     60

tgaatagata gcaaaaggtg tggatggact ggcccacatt ttcttgctct ttaaagatga    120

tattcctaat aataatggac tagagttatt ttgtgtgtgt gatttgagag tcaagtttag    180

tgtcttataa gtgtttttcc ctctgtccct cagatttgga tcatacagca gatgtccagt    240

gagtatagcg ggagttcatt cctttgaaac cacgtcagta ggaagactga atgtttcaat    300

cttggttaca cgcatgggga gatactctgg aggaagcatt tgagcaatgt gcaatggcca    360

tgtttggtta catgacagat actgggacag tggagcccct ccaaacagta gaagtagaaa    420

cccaaggaga tgacttacag tctcttctgt ttcacttttt ggatgaatgg ctttataagt    480

tcagtgctga tgaattcttc ataccccggg tggggagaag aattttcatt gtccaagcac    540

cctcagggaa cagaagtcaa agcaataaca tattcagcaa tgcaggtcta taatgaagag    600

aacccggaag tttttgtgat cattgacatt taagacacca aaaaataaaa gactcctacg    660

aagaactgtt tttgttttcc tcttcctttt gagaagacac tatgaattaa attctacagc    720

ttttttttga tatatggaaa tttgtagaac agaaatattt tagttaaagt gtgactttca    780

gaaagggaaa atcagggcac agccttggtc tgtgttcccc aaatattcac actttaaaga    840

attcttcaac cccccaaggg acagttatgg tcctttgatt ctctgctgtg gcagtaggtg    900

tgcctcatgc ccttccagtg caatgcaagc cctccagcct caccccagag aggatcactg    960

atgtcagcag cagcctgagg ctgaatccag gttgaaagaa gaataacttg aaaaaatata   1020

tttccacaca cagaattttg tttttcttcc aagttggtta agacatatat tttgtttctt   1080

tttttttttt ttttttgaga cggagtctcg ctctgtagcc caggctgaag cgcagtggtg   1140

tgagctcggc ttactgcaag ctccacctcc cgggttcacg ccattctcct acctcagcct   1200

cccgagtagc tgggactata ggcacccgcc accatgcccg gctaattttt gtatctttag   1260

tagagacggg gtttcactgt gttagctagg atggtcttga tctcctgacc ttgtgatccg   1320

cccaccttgg cctcccaagg tactgcgatt acaggcatga gctaccatgc ccggccacaa   1380

gacatagatt ttctatatgc acatcaaggg aggtgctggt ttaggttgct ataggacaga   1440

gctatcctgt attccagttg gtttttgtag agaaacaatt agacttctct agatagagcc   1500

ctgatttttc tctcacgctt tcagtttttt aaaagcacta atgatatttc ctgttttctc   1560

ataagaaaaa gtcaatacta tgccttacaa agagaccttt ccttctaata tagaatttta   1620

tttgaaagtg agtacatgtt tataactaga gaataaaagg agaatttttg aaaaattt     1678


<210>  1624
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  1624

Met Phe Gln Ser Trp Leu His Ala Trp Gly Asp Thr Leu Glu Glu Ala 
1               5                   10                  15


Phe Glu Gln Cys Ala Met Ala Met Phe Gly Tyr Met Thr Asp Thr Gly 
            20                  25                  30


Thr Val Glu Pro Leu Gln Thr Val Glu Val Glu Thr Gln Gly Asp Asp 
        35                  40                  45


Leu Gln Ser Leu Leu Phe His Phe Leu Asp Glu Trp Leu Tyr Lys Phe 
    50                  55                  60


Ser Ala Asp Glu Phe Phe Ile Pro Arg Val Gly Arg Arg Ile Phe Ile 
65                  70                  75                  80


Val Gln Ala Pro Ser Gly Asn Arg Ser Gln Ser Asn Asn Ile Phe Ser 
                85                  90                  95


Asn Ala Gly Leu 
            100


<210>  1625
<211>  1873
<212>  DNA
<213>  Homo sapiens

<400>  1625
gacgggactg cgcccggtca gggtcacgtg agagaggttt ggtccgcaca ctcccgcggc     60

aagagggcag ccattttctt gaaggctatt aagcttacga ccctttcaga gtactgagat    120

gaaaaatcta gaatgccttc gggtctagtt atcaattttg ggggtgaagc gggggaaaga    180

acctcgccag tcagacccag acgggtttca ttcaaggtgc ccttcaacgt ttttccttag    240

tctttggaaa gaactagtaa tgaaggaatc gcagaagatg gggttttggc tttttaaata    300

tgcgatccaa gcggcagggt agggactaaa gtaggtcaac agccaactcc gagaaaggag    360

tgtggtcctt taagggtgtg cgccaagggg cggagtctag agcggaagta gtaactccgg    420

gccgaagtcc ggtggatgaa gggcggaagt agagtgtcta atcctgcagt catggcgcag    480

gaagaggaag atgttagaga ttacaatttg actgaagaac agaaggcgat caaggccaag    540

tatccgccag tcaataggaa gtacgagtga gatgacttac agtctcttct gtttcacttt    600

ttggatgaat ggctttataa gttcagtgct gatgaattct tcataccccg ggaagtgaaa    660

gtacttagca ttgatcaaag aaatttcaaa ttacgatcaa ttgggtgggg agaagaattt    720

tcattgtcca agcaccctca gggaacagaa gtcaaagcaa taacatattc agcaatgcag    780

gtctataatg aagagaaccc ggaagttttt gtgatcattg acatttaaga caccaaaaaa    840

taaaagactc ctacgaagaa ctgtttttgt tttcctcttc cttttgagaa gacactatga    900

attaaattct acagcttttt tttgatatat ggaaatttgt agaacagaaa tattttagtt    960

aaagtgtgac tttcagaaag ggaaaatcag ggcacagcct tggtctgtgt tccccaaata   1020

ttcacacttt aaagaattct tcaacccccc aagggacagt tatggtcctt tgattctctg   1080

ctgtggcagt aggtgtgcct catgcccttc cagtgcaatg caagccctcc agcctcaccc   1140

cagagaggat cactgatgtc agcagcagcc tgaggctgaa tccaggttga aagaagaata   1200

acttgaaaaa atatatttcc acacacagaa ttttgttttt cttccaagtt ggttaagaca   1260

tatattttgt ttcttttttt tttttttttt tgagacggag tctcgctctg tagcccaggc   1320

tgaagcgcag tggtgtgagc tcggcttact gcaagctcca cctcccgggt tcacgccatt   1380

ctcctacctc agcctcccga gtagctggga ctataggcac ccgccaccat gcccggctaa   1440

tttttgtatc tttagtagag acggggtttc actgtgttag ctaggatggt cttgatctcc   1500

tgaccttgtg atccgcccac cttggcctcc caaggtactg cgattacagg catgagctac   1560

catgcccggc cacaagacat agattttcta tatgcacatc aagggaggtg ctggtttagg   1620

ttgctatagg acagagctat cctgtattcc agttggtttt tgtagagaaa caattagact   1680

tctctagata gagccctgat ttttctctca cgctttcagt tttttaaaag cactaatgat   1740

atttcctgtt ttctcataag aaaaagtcaa tactatgcct tacaaagaga cctttccttc   1800

taatatagaa ttttatttga aagtgagtac atgtttataa ctagagaata aaaggagaat   1860

ttttgaaaaa ttt                                                      1873


<210>  1626
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  1626

Met Lys Gly Gly Ser Arg Val Ser Asn Pro Ala Val Met Ala Gln Glu 
1               5                   10                  15


Glu Glu Asp Val Arg Asp Tyr Asn Leu Thr Glu Glu Gln Lys Ala Ile 
            20                  25                  30


Lys Ala Lys Tyr Pro Pro Val Asn Arg Lys Tyr Glu 
        35                  40


<210>  1627
<211>  1704
<212>  DNA
<213>  Homo sapiens

<400>  1627
gacgggactg cgcccggtca gggtcacgtg agagaggttt ggtccgcaca ctcccgcggc     60

aagagggcag ccattttctt gaaggctatt aagcttacga ccctttcaga gtactgagat    120

gaaaaatcta gaatgccttc gggtctagtt atcaattttg ggggtgaagc gggggaaaga    180

acctcgccag tcagacccag acgggtttca ttcaaggtgc ccttcaacgt ttttccttag    240

tctttggaaa gaactagtaa tgaaggaatc gcagaagatg gggttttggc tttttaaata    300

tgcgatccaa gcggcagggt agggactaaa gtaggtcaac agccaactcc gagaaaggag    360

tgtggtcctt taagggtgtg cgccaagggg cggagtctag agcggaagta gtaactccgg    420

gccgaagtcc ggtggatgaa gggcggaagt agagtgtcta atcctgcagt catggcgcag    480

gaagaggaag atgttagaga ttacaatttg actgaagaac agaaggcgat caaggccaag    540

tatccgccag tcaataggaa gtacgagtgt gaggaacaga agtcaaagca ataacatatt    600

cagcaatgca ggtctataat gaagagaacc cggaagtttt tgtgatcatt gacatttaag    660

acaccaaaaa ataaaagact cctacgaaga actgtttttg ttttcctctt ccttttgaga    720

agacactatg aattaaattc tacagctttt ttttgatata tggaaatttg tagaacagaa    780

atattttagt taaagtgtga ctttcagaaa gggaaaatca gggcacagcc ttggtctgtg    840

ttccccaaat attcacactt taaagaattc ttcaaccccc caagggacag ttatggtcct    900

ttgattctct gctgtggcag taggtgtgcc tcatgccctt ccagtgcaat gcaagccctc    960

cagcctcacc ccagagagga tcactgatgt cagcagcagc ctgaggctga atccaggttg   1020

aaagaagaat aacttgaaaa aatatatttc cacacacaga attttgtttt tcttccaagt   1080

tggttaagac atatattttg tttctttttt tttttttttt ttgagacgga gtctcgctct   1140

gtagcccagg ctgaagcgca gtggtgtgag ctcggcttac tgcaagctcc acctcccggg   1200

ttcacgccat tctcctacct cagcctcccg agtagctggg actataggca cccgccacca   1260

tgcccggcta atttttgtat ctttagtaga gacggggttt cactgtgtta gctaggatgg   1320

tcttgatctc ctgaccttgt gatccgccca ccttggcctc ccaaggtact gcgattacag   1380

gcatgagcta ccatgcccgg ccacaagaca tagattttct atatgcacat caagggaggt   1440

gctggtttag gttgctatag gacagagcta tcctgtattc cagttggttt ttgtagagaa   1500

acaattagac ttctctagat agagccctga tttttctctc acgctttcag ttttttaaaa   1560

gcactaatga tatttcctgt tttctcataa gaaaaagtca atactatgcc ttacaaagag   1620

acctttcctt ctaatataga attttatttg aaagtgagta catgtttata actagagaat   1680

aaaaggagaa tttttgaaaa attt                                          1704


<210>  1628
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  1628

Met Lys Gly Gly Ser Arg Val Ser Asn Pro Ala Val Met Ala Gln Glu 
1               5                   10                  15


Glu Glu Asp Val Arg Asp Tyr Asn Leu Thr Glu Glu Gln Lys Ala Ile 
            20                  25                  30


Lys Ala Lys Tyr Pro Pro Val Asn Arg Lys Tyr Glu Cys Glu Glu Gln 
        35                  40                  45


Lys Ser Lys Gln 
    50


<210>  1629
<211>  2058
<212>  DNA
<213>  Homo sapiens

<400>  1629
gacgggactg cgcccggtca gggtcacgtg agagaggttt ggtccgcaca ctcccgcggc     60

aagagggcag ccattttctt gaaggctatt aagcttacga ccctttcaga gtactgagat    120

gaaaaatcta gaatgccttc gggtctagtt atcaattttg ggggtgaagc gggggaaaga    180

acctcgccag tcagacccag acgggtttca ttcaaggtgc ccttcaacgt ttttccttag    240

tctttggaaa gaactagtaa tgaaggaatc gcagaagatg gggttttggc tttttaaata    300

tgcgatccaa gcggcagggt agggactaaa gtaggtcaac agccaactcc gagaaaggag    360

tgtggtcctt taagggtgtg cgccaagggg cggagtctag agcggaagta gtaactccgg    420

gccgaagtcc ggtggatgaa gggcggaagt agagtgtcta atcctgcagt catggcgcag    480

gaagaggaag atgttagaga ttacaatttg actgaagaac agaaggcgat caaggccaag    540

tatccgccag tcaataggaa gtacgagtat ttggatcata cagcagatgt ccatggattg    600

tattacacag agcatgaata tacttcttta ggttacacgc atggggagat actctggagg    660

aagcatttga gcaatgtgca atggccatgt ttggttacat gacagatact gggacagtgg    720

agcccctcca aacagtagaa gtagaaaccc aaggagatga cttacagtct cttctgtttc    780

actttttgga tgaatggctt tataagttca gtgctgatga attcttcata ccccgggaag    840

tgaaagtact tagcattgat caaagaaatt tcaaattacg atcaattggg tggggagaag    900

aattttcatt gtccaagcac cctcagggaa cagaagtcaa agcaataaca tattcagcaa    960

tgcaggtcta taatgaagag aacccggaag tttttgtgat cattgacatt taagacacca   1020

aaaaataaaa gactcctacg aagaactgtt tttgttttcc tcttcctttt gagaagacac   1080

tatgaattaa attctacagc ttttttttga tatatggaaa tttgtagaac agaaatattt   1140

tagttaaagt gtgactttca gaaagggaaa atcagggcac agccttggtc tgtgttcccc   1200

aaatattcac actttaaaga attcttcaac cccccaaggg acagttatgg tcctttgatt   1260

ctctgctgtg gcagtaggtg tgcctcatgc ccttccagtg caatgcaagc cctccagcct   1320

caccccagag aggatcactg atgtcagcag cagcctgagg ctgaatccag gttgaaagaa   1380

gaataacttg aaaaaatata tttccacaca cagaattttg tttttcttcc aagttggtta   1440

agacatatat tttgtttctt tttttttttt ttttttgaga cggagtctcg ctctgtagcc   1500

caggctgaag cgcagtggtg tgagctcggc ttactgcaag ctccacctcc cgggttcacg   1560

ccattctcct acctcagcct cccgagtagc tgggactata ggcacccgcc accatgcccg   1620

gctaattttt gtatctttag tagagacggg gtttcactgt gttagctagg atggtcttga   1680

tctcctgacc ttgtgatccg cccaccttgg cctcccaagg tactgcgatt acaggcatga   1740

gctaccatgc ccggccacaa gacatagatt ttctatatgc acatcaaggg aggtgctggt   1800

ttaggttgct ataggacaga gctatcctgt attccagttg gtttttgtag agaaacaatt   1860

agacttctct agatagagcc ctgatttttc tctcacgctt tcagtttttt aaaagcacta   1920

atgatatttc ctgttttctc ataagaaaaa gtcaatacta tgccttacaa agagaccttt   1980

ccttctaata tagaatttta tttgaaagtg agtacatgtt tataactaga gaataaaagg   2040

agaatttttg aaaaattt                                                 2058


<210>  1630
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  1630

Met Ala Met Phe Gly Tyr Met Thr Asp Thr Gly Thr Val Glu Pro Leu 
1               5                   10                  15


Gln Thr Val Glu Val Glu Thr Gln Gly Asp Asp Leu Gln Ser Leu Leu 
            20                  25                  30


Phe His Phe Leu Asp Glu Trp Leu Tyr Lys Phe Ser Ala Asp Glu Phe 
        35                  40                  45


Phe Ile Pro Arg Glu Val Lys Val Leu Ser Ile Asp Gln Arg Asn Phe 
    50                  55                  60


Lys Leu Arg Ser Ile Gly Trp Gly Glu Glu Phe Ser Leu Ser Lys His 
65                  70                  75                  80


Pro Gln Gly Thr Glu Val Lys Ala Ile Thr Tyr Ser Ala Met Gln Val 
                85                  90                  95


Tyr Asn Glu Glu Asn Pro Glu Val Phe Val Ile Ile Asp Ile 
            100                 105                 110


<210>  1631
<211>  2086
<212>  DNA
<213>  Homo sapiens

<400>  1631
gacgggactg cgcccggtca gggtcacgtg agagaggttt ggtccgcaca ctcccgcggc     60

aagagggcag ccattttctt gaaggctatt aagcttacga ccctttcaga gtactgagat    120

gaaaaatcta gaatgccttc gggtctagtt atcaattttg ggggtgaagc gggggaaaga    180

acctcgccag tcagacccag acgggtttca ttcaaggtgc ccttcaacgt ttttccttag    240

tctttggaaa gaactagtaa tgaaggaatc gcagaagatg gggttttggc tttttaaata    300

tgcgatccaa gcggcagggt agggactaaa gtaggtcaac agccaactcc gagaaaggag    360

tgtggtcctt taagggtgtg cgccaagggg cggagtctag agcggaagta gtaactccgg    420

gccgaagtcc ggtggatgaa gggcggaagt agagtgtcta atcctgcagt catggcgcag    480

gaagaggaag atgttagaga ttacaatttg actgaagaac agaaggcgat caaggccaag    540

tatccgccag tcaataggaa gtacgagtat ttggatcata cagcagatgt ccagtgagta    600

tagcgggagt tcattccttt gaaaccacgt cagtaggaag actgaatgtt tcaatcttgg    660

ttacacgcat ggggagatac tctggaggaa gcatttgagc aatgtgcaat ggccatgttt    720

ggttacatga cagatactgg gacagtggag cccctccaaa cagtagaagt agaaacccaa    780

ggagatgact tacagtctct tctgtttcac tttttggatg aatggcttta taagttcagt    840

gctgatgaat tcttcatacc ccgggaagtg aaagtactta gcattgatca aagaaatttc    900

aaattacgat caattgggtg gggagaagaa ttttcattgt ccaagcaccc tcagggaaca    960

gaagtcaaag caataacata ttcagcaatg caggtctata atgaagagaa cccggaagtt   1020

tttgtgatca ttgacattta agacaccaaa aaataaaaga ctcctacgaa gaactgtttt   1080

tgttttcctc ttccttttga gaagacacta tgaattaaat tctacagctt ttttttgata   1140

tatggaaatt tgtagaacag aaatatttta gttaaagtgt gactttcaga aagggaaaat   1200

cagggcacag ccttggtctg tgttccccaa atattcacac tttaaagaat tcttcaaccc   1260

cccaagggac agttatggtc ctttgattct ctgctgtggc agtaggtgtg cctcatgccc   1320

ttccagtgca atgcaagccc tccagcctca ccccagagag gatcactgat gtcagcagca   1380

gcctgaggct gaatccaggt tgaaagaaga ataacttgaa aaaatatatt tccacacaca   1440

gaattttgtt tttcttccaa gttggttaag acatatattt tgtttctttt tttttttttt   1500

ttttgagacg gagtctcgct ctgtagccca ggctgaagcg cagtggtgtg agctcggctt   1560

actgcaagct ccacctcccg ggttcacgcc attctcctac ctcagcctcc cgagtagctg   1620

ggactatagg cacccgccac catgcccggc taatttttgt atctttagta gagacggggt   1680

ttcactgtgt tagctaggat ggtcttgatc tcctgacctt gtgatccgcc caccttggcc   1740

tcccaaggta ctgcgattac aggcatgagc taccatgccc ggccacaaga catagatttt   1800

ctatatgcac atcaagggag gtgctggttt aggttgctat aggacagagc tatcctgtat   1860

tccagttggt ttttgtagag aaacaattag acttctctag atagagccct gatttttctc   1920

tcacgctttc agttttttaa aagcactaat gatatttcct gttttctcat aagaaaaagt   1980

caatactatg ccttacaaag agacctttcc ttctaatata gaattttatt tgaaagtgag   2040

tacatgttta taactagaga ataaaaggag aatttttgaa aaattt                  2086


<210>  1632
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  1632

Met Phe Gln Ser Trp Leu His Ala Trp Gly Asp Thr Leu Glu Glu Ala 
1               5                   10                  15


Phe Glu Gln Cys Ala Met Ala Met Phe Gly Tyr Met Thr Asp Thr Gly 
            20                  25                  30


Thr Val Glu Pro Leu Gln Thr Val Glu Val Glu Thr Gln Gly Asp Asp 
        35                  40                  45


Leu Gln Ser Leu Leu Phe His Phe Leu Asp Glu Trp Leu Tyr Lys Phe 
    50                  55                  60


Ser Ala Asp Glu Phe Phe Ile Pro Arg Glu Val Lys Val Leu Ser Ile 
65                  70                  75                  80


Asp Gln Arg Asn Phe Lys Leu Arg Ser Ile Gly Trp Gly Glu Glu Phe 
                85                  90                  95


Ser Leu Ser Lys His Pro Gln Gly Thr Glu Val Lys Ala Ile Thr Tyr 
            100                 105                 110


Ser Ala Met Gln Val Tyr Asn Glu Glu Asn Pro Glu Val Phe Val Ile 
        115                 120                 125


Ile Asp Ile 
    130


<210>  1633
<211>  1946
<212>  DNA
<213>  Homo sapiens

<400>  1633
gacgggactg cgcccggtca gggtcacgtg agagaggttt ggtccgcaca ctcccgcggc     60

aagagggcag ccattttctt gaaggctatt aagcttacga ccctttcaga gtactgagat    120

gaaaaatcta gaatgccttc gggtctagtt atcaattttg ggggtgaagc gggggaaaga    180

acctcgccag tcagacccag acgggtttca ttcaaggtgc ccttcaacgt ttttccttag    240

tctttggaaa gaactagtaa tgaaggaatc gcagaagatg gggttttggc tttttaaata    300

tgcgatccaa gcggcagggt agggactaaa gtaggtcaac agccaactcc gagaaaggag    360

tgtggtcctt taagggtgtg cgccaagggg cggagtctag agcggaagta gtaactccgg    420

gccgaagtcc ggtggatgaa gggcggaagt agagtgtcta atcctgcagt catggcgcag    480

gaagaggaag atgttagaga ttacaatttg actgaagaac agaaggcgat caaggccaag    540

tatccgccag tcaataggaa gtacgagtgt gagttacacg catggggaga tactctggag    600

gaagcatttg agcaatgtgc aatggccatg tttggttaca tgacagatac tgggacagtg    660

gagcccctcc aaacagtaga agtagaaacc caaggagatg acttacagtc tcttctgttt    720

cactttttgg atgaatggct ttataagttc agtgctgatg aattcttcat accccgggtg    780

gggagaagaa ttttcattgt ccaagcaccc tcagggaaca gaagtcaaag caataacata    840

ttcagcaatg caggtctata atgaagagaa cccggaagtt tttgtgatca ttgacattta    900

agacaccaaa aaataaaaga ctcctacgaa gaactgtttt tgttttcctc ttccttttga    960

gaagacacta tgaattaaat tctacagctt ttttttgata tatggaaatt tgtagaacag   1020

aaatatttta gttaaagtgt gactttcaga aagggaaaat cagggcacag ccttggtctg   1080

tgttccccaa atattcacac tttaaagaat tcttcaaccc cccaagggac agttatggtc   1140

ctttgattct ctgctgtggc agtaggtgtg cctcatgccc ttccagtgca atgcaagccc   1200

tccagcctca ccccagagag gatcactgat gtcagcagca gcctgaggct gaatccaggt   1260

tgaaagaaga ataacttgaa aaaatatatt tccacacaca gaattttgtt tttcttccaa   1320

gttggttaag acatatattt tgtttctttt tttttttttt ttttgagacg gagtctcgct   1380

ctgtagccca ggctgaagcg cagtggtgtg agctcggctt actgcaagct ccacctcccg   1440

ggttcacgcc attctcctac ctcagcctcc cgagtagctg ggactatagg cacccgccac   1500

catgcccggc taatttttgt atctttagta gagacggggt ttcactgtgt tagctaggat   1560

ggtcttgatc tcctgacctt gtgatccgcc caccttggcc tcccaaggta ctgcgattac   1620

aggcatgagc taccatgccc ggccacaaga catagatttt ctatatgcac atcaagggag   1680

gtgctggttt aggttgctat aggacagagc tatcctgtat tccagttggt ttttgtagag   1740

aaacaattag acttctctag atagagccct gatttttctc tcacgctttc agttttttaa   1800

aagcactaat gatatttcct gttttctcat aagaaaaagt caatactatg ccttacaaag   1860

agacctttcc ttctaatata gaattttatt tgaaagtgag tacatgttta taactagaga   1920

ataaaaggag aatttttgaa aaattt                                        1946


<210>  1634
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  1634

Met Lys Gly Gly Ser Arg Val Ser Asn Pro Ala Val Met Ala Gln Glu 
1               5                   10                  15


Glu Glu Asp Val Arg Asp Tyr Asn Leu Thr Glu Glu Gln Lys Ala Ile 
            20                  25                  30


Lys Ala Lys Tyr Pro Pro Val Asn Arg Lys Tyr Glu Cys Glu Leu His 
        35                  40                  45


Ala Trp Gly Asp Thr Leu Glu Glu Ala Phe Glu Gln Cys Ala Met Ala 
    50                  55                  60


Met Phe Gly Tyr Met Thr Asp Thr Gly Thr Val Glu Pro Leu Gln Thr 
65                  70                  75                  80


Val Glu Val Glu Thr Gln Gly Asp Asp Leu Gln Ser Leu Leu Phe His 
                85                  90                  95


Phe Leu Asp Glu Trp Leu Tyr Lys Phe Ser Ala Asp Glu Phe Phe Ile 
            100                 105                 110


Pro Arg Val Gly Arg Arg Ile Phe Ile Val Gln Ala Pro Ser Gly Asn 
        115                 120                 125


Arg Ser Gln Ser Asn Asn Ile Phe Ser Asn Ala Gly Leu 
    130                 135                 140


<210>  1635
<211>  1762
<212>  DNA
<213>  Homo sapiens

<400>  1635
gacgggactg cgcccggtca gggtcacgtg agagaggttt ggtccgcaca ctcccgcggc     60

aagagggcag ccattttctt gaaggctatt aagcttacga ccctttcaga gtactgagat    120

gaaaaatcta gaatgccttc gggtctagtt atcaattttg ggggtgaagc gggggaaaga    180

acctcgccag tcagacccag acgggtttca ttcaaggtgc ccttcaacgt ttttccttag    240

tctttggaaa gaactagtaa tgaaggaatc gcagaagatg gggttttggc tttttaaata    300

tgcgatccaa gcggcagggt agggactaaa gtaggtcaac agccaactcc gagaaaggag    360

tgtggtcctt taagggtgtg cgccaagggg cggagtctag agcggaagta gtaactccgg    420

gccgaagtcc ggtggatgaa gggcggaagt agagtgtcta atcctgcagt catggcgcag    480

gaagaggaag atgttagaga ttacaatttg actgaagaac agaaggcgat caaggccaag    540

tatccgccag tcaataggaa gtacgagtat ttggatcata cagcagatgt ccagtgggga    600

gaagaatttt cattgtccaa gcaccctcag ggaacagaag tcaaagcaat aacatattca    660

gcaatgcagg tctataatga agagaacccg gaagtttttg tgatcattga catttaagac    720

accaaaaaat aaaagactcc tacgaagaac tgtttttgtt ttcctcttcc ttttgagaag    780

acactatgaa ttaaattcta cagctttttt ttgatatatg gaaatttgta gaacagaaat    840

attttagtta aagtgtgact ttcagaaagg gaaaatcagg gcacagcctt ggtctgtgtt    900

ccccaaatat tcacacttta aagaattctt caacccccca agggacagtt atggtccttt    960

gattctctgc tgtggcagta ggtgtgcctc atgcccttcc agtgcaatgc aagccctcca   1020

gcctcacccc agagaggatc actgatgtca gcagcagcct gaggctgaat ccaggttgaa   1080

agaagaataa cttgaaaaaa tatatttcca cacacagaat tttgtttttc ttccaagttg   1140

gttaagacat atattttgtt tctttttttt tttttttttt gagacggagt ctcgctctgt   1200

agcccaggct gaagcgcagt ggtgtgagct cggcttactg caagctccac ctcccgggtt   1260

cacgccattc tcctacctca gcctcccgag tagctgggac tataggcacc cgccaccatg   1320

cccggctaat ttttgtatct ttagtagaga cggggtttca ctgtgttagc taggatggtc   1380

ttgatctcct gaccttgtga tccgcccacc ttggcctccc aaggtactgc gattacaggc   1440

atgagctacc atgcccggcc acaagacata gattttctat atgcacatca agggaggtgc   1500

tggtttaggt tgctatagga cagagctatc ctgtattcca gttggttttt gtagagaaac   1560

aattagactt ctctagatag agccctgatt tttctctcac gctttcagtt ttttaaaagc   1620

actaatgata tttcctgttt tctcataaga aaaagtcaat actatgcctt acaaagagac   1680

ctttccttct aatatagaat tttatttgaa agtgagtaca tgtttataac tagagaataa   1740

aaggagaatt tttgaaaaat tt                                            1762


<210>  1636
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  1636

Met Lys Gly Gly Ser Arg Val Ser Asn Pro Ala Val Met Ala Gln Glu 
1               5                   10                  15


Glu Glu Asp Val Arg Asp Tyr Asn Leu Thr Glu Glu Gln Lys Ala Ile 
            20                  25                  30


Lys Ala Lys Tyr Pro Pro Val Asn Arg Lys Tyr Glu Tyr Leu Asp His 
        35                  40                  45


Thr Ala Asp Val Gln Trp Gly Glu Glu Phe Ser Leu Ser Lys His Pro 
    50                  55                  60


Gln Gly Thr Glu Val Lys Ala Ile Thr Tyr Ser Ala Met Gln Val Tyr 
65                  70                  75                  80


Asn Glu Glu Asn Pro Glu Val Phe Val Ile Ile Asp Ile 
                85                  90


<210>  1637
<211>  1750
<212>  DNA
<213>  Homo sapiens

<400>  1637
gcgcgccggc gttgacggga ctgcgcccgg tcagggtcac gtgagagagg tttggtccgc     60

acactcccgc ggcaagaggg cagccatttt cttgaaggct attaagctta cgaccctttc    120

agagtactga gatgaaaaat ctagaatgcc ttcgggtcta gttatcaatt ttgggggtga    180

agcgggggaa agaacctcgc cagtcagacc cagacgggtt tcattcaagg tgcccttcaa    240

cgtttttcct tagtctttgg aaagaactag taatgaagga atcgcagaag atggggtttt    300

ggctttttaa atatgcgatc caagcggcag ggtagggact aaagtaggtc aacagccaac    360

tccgagaaag gagtgtggtc ctttaagggt gtgcgccaag gggcggagtc tagagcggaa    420

gtagtaactc cgggccgaag tccggtggat gaagggcgga agtagagtgt ctaatcctgc    480

agtcatggcg caggaagagg aagatgttag agattacaat ttgactgaag aacagaaggc    540

gatcaaggcc aagtatccgc cagtcaatag gaagtacgag tgtggggaga agaattttca    600

ttgtccaagc accctcaggg aacagaagtc aaagcaataa catattcagc aatgcaggtc    660

tataatgaag agaacccgga agtttttgtg atcattgaca tttaagacac caaaaaataa    720

aagactccta cgaagaactg tttttgtttt cctcttcctt ttgagaagac actatgaatt    780

aaattctaca gctttttttt gatatatgga aatttgtaga acagaaatat tttagttaaa    840

gtgtgacttt cagaaaggga aaatcagggc acagccttgg tctgtgttcc ccaaatattc    900

acactttaaa gaattcttca accccccaag ggacagttat ggtcctttga ttctctgctg    960

tggcagtagg tgtgcctcat gcccttccag tgcaatgcaa gccctccagc ctcaccccag   1020

agaggatcac tgatgtcagc agcagcctga ggctgaatcc aggttgaaag aagaataact   1080

tgaaaaaata tatttccaca cacagaattt tgtttttctt ccaagttggt taagacatat   1140

attttgtttc tttttttttt ttttttttga gacggagtct cgctctgtag cccaggctga   1200

agcgcagtgg tgtgagctcg gcttactgca agctccacct cccgggttca cgccattctc   1260

ctacctcagc ctcccgagta gctgggacta taggcacccg ccaccatgcc cggctaattt   1320

ttgtatcttt agtagagacg gggtttcact gtgttagcta ggatggtctt gatctcctga   1380

ccttgtgatc cgcccacctt ggcctcccaa ggtactgcga ttacaggcat gagctaccat   1440

gcccggccac aagacataga ttttctatat gcacatcaag ggaggtgctg gtttaggttg   1500

ctataggaca gagctatcct gtattccagt tggtttttgt agagaaacaa ttagacttct   1560

ctagatagag ccctgatttt tctctcacgc tttcagtttt ttaaaagcac taatgatatt   1620

tcctgttttc tcataagaaa aagtcaatac tatgccttac aaagagacct ttccttctaa   1680

tatagaattt tatttgaaag tgagtacatg tttataacta gagaataaaa ggagaatttt   1740

tgaaaaattt                                                          1750


<210>  1638
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  1638

Met Lys Gly Gly Ser Arg Val Ser Asn Pro Ala Val Met Ala Gln Glu 
1               5                   10                  15


Glu Glu Asp Val Arg Asp Tyr Asn Leu Thr Glu Glu Gln Lys Ala Ile 
            20                  25                  30


Lys Ala Lys Tyr Pro Pro Val Asn Arg Lys Tyr Glu Cys Gly Glu Lys 
        35                  40                  45


Asn Phe His Cys Pro Ser Thr Leu Arg Glu Gln Lys Ser Lys Gln 
    50                  55                  60


<210>  1639
<211>  1993
<212>  DNA
<213>  Homo sapiens

<400>  1639
gcgcgccggc gttgacggga ctgcgcccgg tcagggtcac gtgagagagg tttggtccgc     60

acactcccgc ggcaagaggg cagccatttt cttgaaggct attaagctta cgaccctttc    120

agagtactga gatgaaaaat ctagaatgcc ttcgggtcta gttatcaatt ttgggggtga    180

agcgggggaa agaacctcgc cagtcagacc cagacgggtt tcattcaagg tgcccttcaa    240

cgtttttcct tagtctttgg aaagaactag taatgaagga atcgcagaag atggggtttt    300

ggctttttaa atatgcgatc caagcggcag ggtagggact aaagtaggtc aacagccaac    360

tccgagaaag gagtgtggtc ctttaagggt gtgcgccaag gggcggagtc tagagcggaa    420

gtagtaactc cgggccgaag tccggtggat gaagggcgga agtagagtgt ctaatcctgc    480

agtcatggcg caggaagagg aagatgttag agattacaat ttgactgaag aacagaaggc    540

gatcaaggcc aagtatccgc cagtcaatag gaagtacgag ttggattgta ttacacagag    600

catgaatata cttctttagg ttacacgcat ggggagatac tctggaggaa gcatttgagc    660

aatgtgcaat ggccatgttt ggttacatga cagatactgg gacagtggag cccctccaaa    720

cagtagaagt agaaacccaa ggagatgact tacagtctct tctgtttcac tttttggatg    780

aatggcttta taagttcagt gctgatgaat tcttcatacc ccgggtgggg agaagaattt    840

tcattgtcca agcaccctca gggaacagaa gtcaaagcaa taacatattc agcaatgcag    900

gtctataatg aagagaaccc ggaagttttt gtgatcattg acatttaaga caccaaaaaa    960

taaaagactc ctacgaagaa ctgtttttgt tttcctcttc cttttgagaa gacactatga   1020

attaaattct acagcttttt tttgatatat ggaaatttgt agaacagaaa tattttagtt   1080

aaagtgtgac tttcagaaag ggaaaatcag ggcacagcct tggtctgtgt tccccaaata   1140

ttcacacttt aaagaattct tcaacccccc aagggacagt tatggtcctt tgattctctg   1200

ctgtggcagt aggtgtgcct catgcccttc cagtgcaatg caagccctcc agcctcaccc   1260

cagagaggat cactgatgtc agcagcagcc tgaggctgaa tccaggttga aagaagaata   1320

acttgaaaaa atatatttcc acacacagaa ttttgttttt cttccaagtt ggttaagaca   1380

tatattttgt ttcttttttt tttttttttt tgagacggag tctcgctctg tagcccaggc   1440

tgaagcgcag tggtgtgagc tcggcttact gcaagctcca cctcccgggt tcacgccatt   1500

ctcctacctc agcctcccga gtagctggga ctataggcac ccgccaccat gcccggctaa   1560

tttttgtatc tttagtagag acggggtttc actgtgttag ctaggatggt cttgatctcc   1620

tgaccttgtg atccgcccac cttggcctcc caaggtactg cgattacagg catgagctac   1680

catgcccggc cacaagacat agattttcta tatgcacatc aagggaggtg ctggtttagg   1740

ttgctatagg acagagctat cctgtattcc agttggtttt tgtagagaaa caattagact   1800

tctctagata gagccctgat ttttctctca cgctttcagt tttttaaaag cactaatgat   1860

atttcctgtt ttctcataag aaaaagtcaa tactatgcct tacaaagaga cctttccttc   1920

taatatagaa ttttatttga aagtgagtac atgtttataa ctagagaata aaaggagaat   1980

ttttgaaaaa ttt                                                      1993


<210>  1640
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  1640

Met Ala Met Phe Gly Tyr Met Thr Asp Thr Gly Thr Val Glu Pro Leu 
1               5                   10                  15


Gln Thr Val Glu Val Glu Thr Gln Gly Asp Asp Leu Gln Ser Leu Leu 
            20                  25                  30


Phe His Phe Leu Asp Glu Trp Leu Tyr Lys Phe Ser Ala Asp Glu Phe 
        35                  40                  45


Phe Ile Pro Arg Val Gly Arg Arg Ile Phe Ile Val Gln Ala Pro Ser 
    50                  55                  60


Gly Asn Arg Ser Gln Ser Asn Asn Ile Phe Ser Asn Ala Gly Leu 
65                  70                  75


<210>  1641
<211>  2033
<212>  DNA
<213>  Homo sapiens

<400>  1641
gcgcgccggc gttgacggga ctgcgcccgg tcagggtcac gtgagagagg tttggtccgc     60

acactcccgc ggcaagaggg cagccatttt cttgaaggct attaagctta cgaccctttc    120

agagtactga gatgaaaaat ctagaatgcc ttcgggtcta gttatcaatt ttgggggtga    180

agcgggggaa agaacctcgc cagtcagacc cagacgggtt tcattcaagg tgcccttcaa    240

cgtttttcct tagtctttgg aaagaactag taatgaagga atcgcagaag atggggtttt    300

ggctttttaa atatgcgatc caagcggcag ggtagggact aaagtaggtc aacagccaac    360

tccgagaaag gagtgtggtc ctttaagggt gtgcgccaag gggcggagtc tagagcggaa    420

gtagtaactc cgggccgaag tccggtggat gaagggcgga agtagagtgt ctaatcctgc    480

agtcatggcg caggaagagg aagatgttag agattacaat ttgactgaag aacagaaggc    540

gatcaaggcc aagtatccgc cagtcaatag gaagtacgag tatttggatc atacagcaga    600

tgtccagtta cacgcatggg gagatactct ggaggaagca tttgagcaat gtgcaatggc    660

catgtttggt tacatgacag atactgggac agtggagccc ctccaaacag tagaagtaga    720

aacccaagga gatgacttac agtctcttct gtttcacttt ttggatgaat ggctttataa    780

gttcagtgct gatgaattct tcataccccg ggaagtgaaa gtacttagca ttgatcaaag    840

aaatttcaaa ttacgatcaa ttgggtgggg agaagaattt tcattgtcca agcaccctca    900

gggaacagaa gtcaaagcaa taacatattc agcaatgcag gtctataatg aagagaaccc    960

ggaagttttt gtgatcattg acatttaaga caccaaaaaa taaaagactc ctacgaagaa   1020

ctgtttttgt tttcctcttc cttttgagaa gacactatga attaaattct acagcttttt   1080

tttgatatat ggaaatttgt agaacagaaa tattttagtt aaagtgtgac tttcagaaag   1140

ggaaaatcag ggcacagcct tggtctgtgt tccccaaata ttcacacttt aaagaattct   1200

tcaacccccc aagggacagt tatggtcctt tgattctctg ctgtggcagt aggtgtgcct   1260

catgcccttc cagtgcaatg caagccctcc agcctcaccc cagagaggat cactgatgtc   1320

agcagcagcc tgaggctgaa tccaggttga aagaagaata acttgaaaaa atatatttcc   1380

acacacagaa ttttgttttt cttccaagtt ggttaagaca tatattttgt ttcttttttt   1440

tttttttttt tgagacggag tctcgctctg tagcccaggc tgaagcgcag tggtgtgagc   1500

tcggcttact gcaagctcca cctcccgggt tcacgccatt ctcctacctc agcctcccga   1560

gtagctggga ctataggcac ccgccaccat gcccggctaa tttttgtatc tttagtagag   1620

acggggtttc actgtgttag ctaggatggt cttgatctcc tgaccttgtg atccgcccac   1680

cttggcctcc caaggtactg cgattacagg catgagctac catgcccggc cacaagacat   1740

agattttcta tatgcacatc aagggaggtg ctggtttagg ttgctatagg acagagctat   1800

cctgtattcc agttggtttt tgtagagaaa caattagact tctctagata gagccctgat   1860

ttttctctca cgctttcagt tttttaaaag cactaatgat atttcctgtt ttctcataag   1920

aaaaagtcaa tactatgcct tacaaagaga cctttccttc taatatagaa ttttatttga   1980

aagtgagtac atgtttataa ctagagaata aaaggagaat ttttgaaaaa ttt          2033


<210>  1642
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  1642

Met Lys Gly Gly Ser Arg Val Ser Asn Pro Ala Val Met Ala Gln Glu 
1               5                   10                  15


Glu Glu Asp Val Arg Asp Tyr Asn Leu Thr Glu Glu Gln Lys Ala Ile 
            20                  25                  30


Lys Ala Lys Tyr Pro Pro Val Asn Arg Lys Tyr Glu Tyr Leu Asp His 
        35                  40                  45


Thr Ala Asp Val Gln Leu His Ala Trp Gly Asp Thr Leu Glu Glu Ala 
    50                  55                  60


Phe Glu Gln Cys Ala Met Ala Met Phe Gly Tyr Met Thr Asp Thr Gly 
65                  70                  75                  80


Thr Val Glu Pro Leu Gln Thr Val Glu Val Glu Thr Gln Gly Asp Asp 
                85                  90                  95


Leu Gln Ser Leu Leu Phe His Phe Leu Asp Glu Trp Leu Tyr Lys Phe 
            100                 105                 110


Ser Ala Asp Glu Phe Phe Ile Pro Arg Glu Val Lys Val Leu Ser Ile 
        115                 120                 125


Asp Gln Arg Asn Phe Lys Leu Arg Ser Ile Gly Trp Gly Glu Glu Phe 
    130                 135                 140


Ser Leu Ser Lys His Pro Gln Gly Thr Glu Val Lys Ala Ile Thr Tyr 
145                 150                 155                 160


Ser Ala Met Gln Val Tyr Asn Glu Glu Asn Pro Glu Val Phe Val Ile 
                165                 170                 175


Ile Asp Ile 



<210>  1643
<211>  1980
<212>  DNA
<213>  Homo sapiens

<400>  1643
gcgcgccggc gttgacggga ctgcgcccgg tcagggtcac gtgagagagg tttggtccgc     60

acactcccgc ggcaagaggg cagccatttt cttgaaggct attaagctta cgaccctttc    120

agagtactga gatgaaaaat ctagaatgcc ttcgggtcta gttatcaatt ttgggggtga    180

agcgggggaa agaacctcgc cagtcagacc cagacgggtt tcattcaagg tgcccttcaa    240

cgtttttcct tagtctttgg aaagaactag taatgaagga atcgcagaag atggggtttt    300

ggctttttaa atatgcgatc caagcggcag ggtagggact aaagtaggtc aacagccaac    360

tccgagaaag gagtgtggtc ctttaagggt gtgcgccaag gggcggagtc tagagcggaa    420

gtagtaactc cgggccgaag tccggtggat gaagggcgga agtagagtgt ctaatcctgc    480

agtcatggcg caggaagagg aagatgttag agattacaat ttgactgaag aacagaaggc    540

gatcaaggcc aagtatccgc cagtcaatag gaagtacgag tatttggatc atacagcaga    600

tgtccagtta cacgcatggg gagatactct ggaggaagca tttgagcaat gtgcaatggc    660

catgtttggt tacatgacag atactgggac agtggagccc ctccaaacag tagaagtaga    720

aacccaagga gatgacttac agtctcttct gtttcacttt ttggatgaat ggctttataa    780

gttcagtgct gatgaattct tcataccccg ggtggggaga agaattttca ttgtccaagc    840

accctcaggg aacagaagtc aaagcaataa catattcagc aatgcaggtc tataatgaag    900

agaacccgga agtttttgtg atcattgaca tttaagacac caaaaaataa aagactccta    960

cgaagaactg tttttgtttt cctcttcctt ttgagaagac actatgaatt aaattctaca   1020

gctttttttt gatatatgga aatttgtaga acagaaatat tttagttaaa gtgtgacttt   1080

cagaaaggga aaatcagggc acagccttgg tctgtgttcc ccaaatattc acactttaaa   1140

gaattcttca accccccaag ggacagttat ggtcctttga ttctctgctg tggcagtagg   1200

tgtgcctcat gcccttccag tgcaatgcaa gccctccagc ctcaccccag agaggatcac   1260

tgatgtcagc agcagcctga ggctgaatcc aggttgaaag aagaataact tgaaaaaata   1320

tatttccaca cacagaattt tgtttttctt ccaagttggt taagacatat attttgtttc   1380

tttttttttt ttttttttga gacggagtct cgctctgtag cccaggctga agcgcagtgg   1440

tgtgagctcg gcttactgca agctccacct cccgggttca cgccattctc ctacctcagc   1500

ctcccgagta gctgggacta taggcacccg ccaccatgcc cggctaattt ttgtatcttt   1560

agtagagacg gggtttcact gtgttagcta ggatggtctt gatctcctga ccttgtgatc   1620

cgcccacctt ggcctcccaa ggtactgcga ttacaggcat gagctaccat gcccggccac   1680

aagacataga ttttctatat gcacatcaag ggaggtgctg gtttaggttg ctataggaca   1740

gagctatcct gtattccagt tggtttttgt agagaaacaa ttagacttct ctagatagag   1800

ccctgatttt tctctcacgc tttcagtttt ttaaaagcac taatgatatt tcctgttttc   1860

tcataagaaa aagtcaatac tatgccttac aaagagacct ttccttctaa tatagaattt   1920

tatttgaaag tgagtacatg tttataacta gagaataaaa ggagaatttt tgaaaaattt   1980


<210>  1644
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  1644

Met Lys Gly Gly Ser Arg Val Ser Asn Pro Ala Val Met Ala Gln Glu 
1               5                   10                  15


Glu Glu Asp Val Arg Asp Tyr Asn Leu Thr Glu Glu Gln Lys Ala Ile 
            20                  25                  30


Lys Ala Lys Tyr Pro Pro Val Asn Arg Lys Tyr Glu Tyr Leu Asp His 
        35                  40                  45


Thr Ala Asp Val Gln Leu His Ala Trp Gly Asp Thr Leu Glu Glu Ala 
    50                  55                  60


Phe Glu Gln Cys Ala Met Ala Met Phe Gly Tyr Met Thr Asp Thr Gly 
65                  70                  75                  80


Thr Val Glu Pro Leu Gln Thr Val Glu Val Glu Thr Gln Gly Asp Asp 
                85                  90                  95


Leu Gln Ser Leu Leu Phe His Phe Leu Asp Glu Trp Leu Tyr Lys Phe 
            100                 105                 110


Ser Ala Asp Glu Phe Phe Ile Pro Arg Val Gly Arg Arg Ile Phe Ile 
        115                 120                 125


Val Gln Ala Pro Ser Gly Asn Arg Ser Gln Ser Asn Asn Ile Phe Ser 
    130                 135                 140


Asn Ala Gly Leu 
145


<210>  1645
<211>  2046
<212>  DNA
<213>  Homo sapiens

<400>  1645
gcgcgccggc gttgacggga ctgcgcccgg tcagggtcac gtgagagagg tttggtccgc     60

acactcccgc ggcaagaggg cagccatttt cttgaaggct attaagctta cgaccctttc    120

agagtactga gatgaaaaat ctagaatgcc ttcgggtcta gttatcaatt ttgggggtga    180

agcgggggaa agaacctcgc cagtcagacc cagacgggtt tcattcaagg tgcccttcaa    240

cgtttttcct tagtctttgg aaagaactag taatgaagga atcgcagaag atggggtttt    300

ggctttttaa atatgcgatc caagcggcag ggtagggact aaagtaggtc aacagccaac    360

tccgagaaag gagtgtggtc ctttaagggt gtgcgccaag gggcggagtc tagagcggaa    420

gtagtaactc cgggccgaag tccggtggat gaagggcgga agtagagtgt ctaatcctgc    480

agtcatggcg caggaagagg aagatgttag agattacaat ttgactgaag aacagaaggc    540

gatcaaggcc aagtatccgc cagtcaatag gaagtacgag ttggattgta ttacacagag    600

catgaatata cttctttagg ttacacgcat ggggagatac tctggaggaa gcatttgagc    660

aatgtgcaat ggccatgttt ggttacatga cagatactgg gacagtggag cccctccaaa    720

cagtagaagt agaaacccaa ggagatgact tacagtctct tctgtttcac tttttggatg    780

aatggcttta taagttcagt gctgatgaat tcttcatacc ccgggaagtg aaagtactta    840

gcattgatca aagaaatttc aaattacgat caattgggtg gggagaagaa ttttcattgt    900

ccaagcaccc tcagggaaca gaagtcaaag caataacata ttcagcaatg caggtctata    960

atgaagagaa cccggaagtt tttgtgatca ttgacattta agacaccaaa aaataaaaga   1020

ctcctacgaa gaactgtttt tgttttcctc ttccttttga gaagacacta tgaattaaat   1080

tctacagctt ttttttgata tatggaaatt tgtagaacag aaatatttta gttaaagtgt   1140

gactttcaga aagggaaaat cagggcacag ccttggtctg tgttccccaa atattcacac   1200

tttaaagaat tcttcaaccc cccaagggac agttatggtc ctttgattct ctgctgtggc   1260

agtaggtgtg cctcatgccc ttccagtgca atgcaagccc tccagcctca ccccagagag   1320

gatcactgat gtcagcagca gcctgaggct gaatccaggt tgaaagaaga ataacttgaa   1380

aaaatatatt tccacacaca gaattttgtt tttcttccaa gttggttaag acatatattt   1440

tgtttctttt tttttttttt ttttgagacg gagtctcgct ctgtagccca ggctgaagcg   1500

cagtggtgtg agctcggctt actgcaagct ccacctcccg ggttcacgcc attctcctac   1560

ctcagcctcc cgagtagctg ggactatagg cacccgccac catgcccggc taatttttgt   1620

atctttagta gagacggggt ttcactgtgt tagctaggat ggtcttgatc tcctgacctt   1680

gtgatccgcc caccttggcc tcccaaggta ctgcgattac aggcatgagc taccatgccc   1740

ggccacaaga catagatttt ctatatgcac atcaagggag gtgctggttt aggttgctat   1800

aggacagagc tatcctgtat tccagttggt ttttgtagag aaacaattag acttctctag   1860

atagagccct gatttttctc tcacgctttc agttttttaa aagcactaat gatatttcct   1920

gttttctcat aagaaaaagt caatactatg ccttacaaag agacctttcc ttctaatata   1980

gaattttatt tgaaagtgag tacatgttta taactagaga ataaaaggag aatttttgaa   2040

aaattt                                                              2046


<210>  1646
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  1646

Met Ala Met Phe Gly Tyr Met Thr Asp Thr Gly Thr Val Glu Pro Leu 
1               5                   10                  15


Gln Thr Val Glu Val Glu Thr Gln Gly Asp Asp Leu Gln Ser Leu Leu 
            20                  25                  30


Phe His Phe Leu Asp Glu Trp Leu Tyr Lys Phe Ser Ala Asp Glu Phe 
        35                  40                  45


Phe Ile Pro Arg Glu Val Lys Val Leu Ser Ile Asp Gln Arg Asn Phe 
    50                  55                  60


Lys Leu Arg Ser Ile Gly Trp Gly Glu Glu Phe Ser Leu Ser Lys His 
65                  70                  75                  80


Pro Gln Gly Thr Glu Val Lys Ala Ile Thr Tyr Ser Ala Met Gln Val 
                85                  90                  95


Tyr Asn Glu Glu Asn Pro Glu Val Phe Val Ile Ile Asp Ile 
            100                 105                 110


<210>  1647
<211>  2012
<212>  DNA
<213>  Homo sapiens

<400>  1647
gcgcgccggc gttgacggga ctgcgcccgg tcagggtcac gtgagagagg tttggtccgc     60

acactcccgc ggcaagaggg cagccatttt cttgaaggct attaagctta cgaccctttc    120

agagtactga gatgaaaaat ctagaatgcc ttcgggtcta gttatcaatt ttgggggtga    180

agcgggggaa agaacctcgc cagtcagacc cagacgggtt tcattcaagg tgcccttcaa    240

cgtttttcct tagtctttgg aaagaactag taatgaagga atcgcagaag atggggtttt    300

ggctttttaa atatgcgatc caagcggcag ggtagggact aaagtaggtc aacagccaac    360

tccgagaaag gagtgtggtc ctttaagggt gtgcgccaag gggcggagtc tagagcggaa    420

gtagtaactc cgggccgaag tccggtggat gaagggcgga agtagagtgt ctaatcctgc    480

agtcatggcg caggaagagg aagatgttag agattacaat ttgactgaag aacagaaggc    540

gatcaaggcc aagtatccgc cagtcaatag gaagtacgag tgtgagttac acgcatgggg    600

agatactctg gaggaagcat ttgagcaatg tgcaatggcc atgtttggtt acatgacaga    660

tactgggaca gtggagcccc tccaaacagt agaagtagaa acccaaggag atgacttaca    720

gtctcttctg tttcactttt tggatgaatg gctttataag ttcagtgctg atgaattctt    780

cataccccgg gaagtgaaag tacttagcat tgatcaaaga aatttcaaat tacgatcaat    840

tgggtgggga gaagaatttt cattgtccaa gcaccctcag ggaacagaag tcaaagcaat    900

aacatattca gcaatgcagg tctataatga agagaacccg gaagtttttg tgatcattga    960

catttaagac accaaaaaat aaaagactcc tacgaagaac tgtttttgtt ttcctcttcc   1020

ttttgagaag acactatgaa ttaaattcta cagctttttt ttgatatatg gaaatttgta   1080

gaacagaaat attttagtta aagtgtgact ttcagaaagg gaaaatcagg gcacagcctt   1140

ggtctgtgtt ccccaaatat tcacacttta aagaattctt caacccccca agggacagtt   1200

atggtccttt gattctctgc tgtggcagta ggtgtgcctc atgcccttcc agtgcaatgc   1260

aagccctcca gcctcacccc agagaggatc actgatgtca gcagcagcct gaggctgaat   1320

ccaggttgaa agaagaataa cttgaaaaaa tatatttcca cacacagaat tttgtttttc   1380

ttccaagttg gttaagacat atattttgtt tctttttttt tttttttttt gagacggagt   1440

ctcgctctgt agcccaggct gaagcgcagt ggtgtgagct cggcttactg caagctccac   1500

ctcccgggtt cacgccattc tcctacctca gcctcccgag tagctgggac tataggcacc   1560

cgccaccatg cccggctaat ttttgtatct ttagtagaga cggggtttca ctgtgttagc   1620

taggatggtc ttgatctcct gaccttgtga tccgcccacc ttggcctccc aaggtactgc   1680

gattacaggc atgagctacc atgcccggcc acaagacata gattttctat atgcacatca   1740

agggaggtgc tggtttaggt tgctatagga cagagctatc ctgtattcca gttggttttt   1800

gtagagaaac aattagactt ctctagatag agccctgatt tttctctcac gctttcagtt   1860

ttttaaaagc actaatgata tttcctgttt tctcataaga aaaagtcaat actatgcctt   1920

acaaagagac ctttccttct aatatagaat tttatttgaa agtgagtaca tgtttataac   1980

tagagaataa aaggagaatt tttgaaaaat tt                                 2012


<210>  1648
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  1648

Met Lys Gly Gly Ser Arg Val Ser Asn Pro Ala Val Met Ala Gln Glu 
1               5                   10                  15


Glu Glu Asp Val Arg Asp Tyr Asn Leu Thr Glu Glu Gln Lys Ala Ile 
            20                  25                  30


Lys Ala Lys Tyr Pro Pro Val Asn Arg Lys Tyr Glu Cys Glu Leu His 
        35                  40                  45


Ala Trp Gly Asp Thr Leu Glu Glu Ala Phe Glu Gln Cys Ala Met Ala 
    50                  55                  60


Met Phe Gly Tyr Met Thr Asp Thr Gly Thr Val Glu Pro Leu Gln Thr 
65                  70                  75                  80


Val Glu Val Glu Thr Gln Gly Asp Asp Leu Gln Ser Leu Leu Phe His 
                85                  90                  95


Phe Leu Asp Glu Trp Leu Tyr Lys Phe Ser Ala Asp Glu Phe Phe Ile 
            100                 105                 110


Pro Arg Glu Val Lys Val Leu Ser Ile Asp Gln Arg Asn Phe Lys Leu 
        115                 120                 125


Arg Ser Ile Gly Trp Gly Glu Glu Phe Ser Leu Ser Lys His Pro Gln 
    130                 135                 140


Gly Thr Glu Val Lys Ala Ile Thr Tyr Ser Ala Met Gln Val Tyr Asn 
145                 150                 155                 160


Glu Glu Asn Pro Glu Val Phe Val Ile Ile Asp Ile 
                165                 170


<210>  1649
<211>  386
<212>  DNA
<213>  Homo sapiens

<400>  1649
ctgtactcca gcctgggcga tggagtaagg ctccatctca aaaaaaaaaa aaaaaaaaaa     60

aaaaaaggtt ttaccaattt ttagtagatg gtccaaaaaa acaaaacaga acaaaaagat    120

ttttagtaga tagtctatta tgaacttttt ttaattaaaa aatttttctt cctgtctagg    180

aagtgaaagt acttagcatt gatcaaagaa atttcaaatt acgatcaatt gggtggggag    240

aagaattttc attgtccaag caccctcagg gaacagaagt caaagcaata acatattcag    300

caatgcaggt ctataatgaa gagaacccgg aagtttttgt gatcattgac atttaagaca    360

ccaaaaaata aaagactcct acgaag                                         386


<210>  1650
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  1650

Ser Lys Lys Phe Gln Ile Thr Ile Asn Trp Val Gly Arg Arg Ile Phe 
1               5                   10                  15


Ile Val Gln Ala Pro Ser Gly Asn Arg Ser Gln Ser Asn Asn Ile Phe 
            20                  25                  30


Ser Asn Ala Gly Leu 
        35


<210>  1651
<211>  492
<212>  DNA
<213>  Homo sapiens

<400>  1651
tttgaaacca cgtcagtagg aagactgaat gtttcaatct tgtggattgt attacacaga     60

gcatgaatat acttctttag gttacacgca tggggagata ctctggagga agcatttgag    120

caatgtgcaa tggccatgtt tggttacatg acagatactg ggacagtgga gcccctccaa    180

acagtagaag tagaaaccca aggagatgac ttacagtctc ttctgtttca ctttttggat    240

gaatggcttt ataagttcag tgctgatgaa ttcttcatac cccgggaagt gaaagtactt    300

agcattgatc aaagaaattt caaattacga tcaattgggt ggggagaaga attttcattg    360

tccaagcacc ctcagggaac agaagtcaaa gcaataacat attcagcaat gcaggtctat    420

aatgaagaga acccggaagt ttttgtgatc attgacattt aagacaccaa aaaataaaag    480

actcctacga ag                                                        492


<210>  1652
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  1652

Met Ala Met Phe Gly Tyr Met Thr Asp Thr Gly Thr Val Glu Pro Leu 
1               5                   10                  15


Gln Thr Val Glu Val Glu Thr Gln Gly Asp Asp Leu Gln Ser Leu Leu 
            20                  25                  30


Phe His Phe Leu Asp Glu Trp Leu Tyr Lys Phe Ser Ala Asp Glu Phe 
        35                  40                  45


Phe Ile Pro Arg Glu Val Lys Val Leu Ser Ile Asp Gln Arg Asn Phe 
    50                  55                  60


Lys Leu Arg Ser Ile Gly Trp Gly Glu Glu Phe Ser Leu Ser Lys His 
65                  70                  75                  80


Pro Gln Gly Thr Glu Val Lys Ala Ile Thr Tyr Ser Ala Met Gln Val 
                85                  90                  95


Tyr Asn Glu Glu Asn Pro Glu Val Phe Val Ile Ile Asp Ile 
            100                 105                 110


<210>  1653
<211>  663
<212>  DNA
<213>  Homo sapiens

<400>  1653
ctctctgtcc ccgcaaaaaa aaaaagattc caacaaagca aagcaattag ctttgttgag     60

tgaatagata gcaaaaggtg tggatggact ggcccacatt ttcttgctct ttaaagatga    120

tattcctaat aataatggac tagagttatt ttgtgtgtgt gatttgagag tcaagtttag    180

tgtcttataa gtgtttttcc ctctgtccct cagatttgga tcatacagca gatgtccagt    240

gagtatagcg ggagttcatt cctttgaaac cacgtcagta ggaagactga atgtttcaat    300

cttggttaca cgcatgggga gatactctgg aggaagcatt tgagcaatgt gcaatggcca    360

tgtttggtta catgacagat actgggacag tggagcccct ccaaacagta gaagtagaaa    420

cccaaggaga tgacttacag tctcttctgt ttcacttttt ggatgaatgg ctttataagt    480

tcagtgctga tgaattcttc ataccccggg tggggagaag aattttcatt gtccaagcac    540

cctcagggaa cagaagtcaa agcaataaca tattcagcaa tgcaggtcta taatgaagag    600

aacccggaag tttttgtgat cattgacatt taagacacca aaaaataaaa gactcctacg    660

aag                                                                  663


<210>  1654
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  1654

Met Phe Gln Ser Trp Leu His Ala Trp Gly Asp Thr Leu Glu Glu Ala 
1               5                   10                  15


Phe Glu Gln Cys Ala Met Ala Met Phe Gly Tyr Met Thr Asp Thr Gly 
            20                  25                  30


Thr Val Glu Pro Leu Gln Thr Val Glu Val Glu Thr Gln Gly Asp Asp 
        35                  40                  45


Leu Gln Ser Leu Leu Phe His Phe Leu Asp Glu Trp Leu Tyr Lys Phe 
    50                  55                  60


Ser Ala Asp Glu Phe Phe Ile Pro Arg Val Gly Arg Arg Ile Phe Ile 
65                  70                  75                  80


Val Gln Ala Pro Ser Gly Asn Arg Ser Gln Ser Asn Asn Ile Phe Ser 
                85                  90                  95


Asn Ala Gly Leu 
            100


<210>  1655
<211>  931
<212>  DNA
<213>  Homo sapiens

<400>  1655
gacgggactg cgcccggtca gggtcacgtg agagaggttt ggtccgcaca ctcccgcggc     60

aagagggcag ccattttctt gaaggctatt aagcttacga ccctttcaga gtactgagat    120

gaaaaatcta gaatgccttc gggtctagtt atcaattttg ggggtgaagc gggggaaaga    180

acctcgccag tcagacccag acgggtttca ttcaaggtgc ccttcaacgt ttttccttag    240

tctttggaaa gaactagtaa tgaaggaatc gcagaagatg gggttttggc tttttaaata    300

tgcgatccaa gcggcagggt agggactaaa gtaggtcaac agccaactcc gagaaaggag    360

tgtggtcctt taagggtgtg cgccaagggg cggagtctag agcggaagta gtaactccgg    420

gccgaagtcc ggtggatgaa gggcggaagt agagtgtcta atcctgcagt catggcgcag    480

gaagaggaag atgttagaga ttacaatttg actgaagaac agaaggcgat caaggccaag    540

tatccgccag tcaataggaa gtacgagtgt gagttacacg catggggaga tactctggag    600

gaagcatttg agcaatgtgc aatggccatg tttggttaca tgacagatac tgggacagtg    660

gagcccctcc aaacagtaga agtagaaacc caaggagatg acttacagtc tcttctgttt    720

cactttttgg atgaatggct ttataagttc agtgctgatg aattcttcat accccgggtg    780

gggagaagaa ttttcattgt ccaagcaccc tcagggaaca gaagtcaaag caataacata    840

ttcagcaatg caggtctata atgaagagaa cccggaagtt tttgtgatca ttgacattta    900

agacaccaaa aaataaaaga ctcctacgaa g                                   931


<210>  1656
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  1656

Met Lys Gly Gly Ser Arg Val Ser Asn Pro Ala Val Met Ala Gln Glu 
1               5                   10                  15


Glu Glu Asp Val Arg Asp Tyr Asn Leu Thr Glu Glu Gln Lys Ala Ile 
            20                  25                  30


Lys Ala Lys Tyr Pro Pro Val Asn Arg Lys Tyr Glu Cys Glu Leu His 
        35                  40                  45


Ala Trp Gly Asp Thr Leu Glu Glu Ala Phe Glu Gln Cys Ala Met Ala 
    50                  55                  60


Met Phe Gly Tyr Met Thr Asp Thr Gly Thr Val Glu Pro Leu Gln Thr 
65                  70                  75                  80


Val Glu Val Glu Thr Gln Gly Asp Asp Leu Gln Ser Leu Leu Phe His 
                85                  90                  95


Phe Leu Asp Glu Trp Leu Tyr Lys Phe Ser Ala Asp Glu Phe Phe Ile 
            100                 105                 110


Pro Arg Val Gly Arg Arg Ile Phe Ile Val Gln Ala Pro Ser Gly Asn 
        115                 120                 125


Arg Ser Gln Ser Asn Asn Ile Phe Ser Asn Ala Gly Leu 
    130                 135                 140


<210>  1657
<211>  689
<212>  DNA
<213>  Homo sapiens

<400>  1657
gacgggactg cgcccggtca gggtcacgtg agagaggttt ggtccgcaca ctcccgcggc     60

aagagggcag ccattttctt gaaggctatt aagcttacga ccctttcaga gtactgagat    120

gaaaaatcta gaatgccttc gggtctagtt atcaattttg ggggtgaagc gggggaaaga    180

acctcgccag tcagacccag acgggtttca ttcaaggtgc ccttcaacgt ttttccttag    240

tctttggaaa gaactagtaa tgaaggaatc gcagaagatg gggttttggc tttttaaata    300

tgcgatccaa gcggcagggt agggactaaa gtaggtcaac agccaactcc gagaaaggag    360

tgtggtcctt taagggtgtg cgccaagggg cggagtctag agcggaagta gtaactccgg    420

gccgaagtcc ggtggatgaa gggcggaagt agagtgtcta atcctgcagt catggcgcag    480

gaagaggaag atgttagaga ttacaatttg actgaagaac agaaggcgat caaggccaag    540

tatccgccag tcaataggaa gtacgagtgt gaggaacaga agtcaaagca ataacatatt    600

cagcaatgca ggtctataat gaagagaacc cggaagtttt tgtgatcatt gacatttaag    660

acaccaaaaa ataaaagact cctacgaag                                      689


<210>  1658
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  1658

Met Lys Gly Gly Ser Arg Val Ser Asn Pro Ala Val Met Ala Gln Glu 
1               5                   10                  15


Glu Glu Asp Val Arg Asp Tyr Asn Leu Thr Glu Glu Gln Lys Ala Ile 
            20                  25                  30


Lys Ala Lys Tyr Pro Pro Val Asn Arg Lys Tyr Glu Cys Glu Glu Gln 
        35                  40                  45


Lys Ser Lys Gln 
    50


<210>  1659
<211>  747
<212>  DNA
<213>  Homo sapiens

<400>  1659
gacgggactg cgcccggtca gggtcacgtg agagaggttt ggtccgcaca ctcccgcggc     60

aagagggcag ccattttctt gaaggctatt aagcttacga ccctttcaga gtactgagat    120

gaaaaatcta gaatgccttc gggtctagtt atcaattttg ggggtgaagc gggggaaaga    180

acctcgccag tcagacccag acgggtttca ttcaaggtgc ccttcaacgt ttttccttag    240

tctttggaaa gaactagtaa tgaaggaatc gcagaagatg gggttttggc tttttaaata    300

tgcgatccaa gcggcagggt agggactaaa gtaggtcaac agccaactcc gagaaaggag    360

tgtggtcctt taagggtgtg cgccaagggg cggagtctag agcggaagta gtaactccgg    420

gccgaagtcc ggtggatgaa gggcggaagt agagtgtcta atcctgcagt catggcgcag    480

gaagaggaag atgttagaga ttacaatttg actgaagaac agaaggcgat caaggccaag    540

tatccgccag tcaataggaa gtacgagtat ttggatcata cagcagatgt ccagtgggga    600

gaagaatttt cattgtccaa gcaccctcag ggaacagaag tcaaagcaat aacatattca    660

gcaatgcagg tctataatga agagaacccg gaagtttttg tgatcattga catttaagac    720

accaaaaaat aaaagactcc tacgaag                                        747


<210>  1660
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  1660

Met Lys Gly Gly Ser Arg Val Ser Asn Pro Ala Val Met Ala Gln Glu 
1               5                   10                  15


Glu Glu Asp Val Arg Asp Tyr Asn Leu Thr Glu Glu Gln Lys Ala Ile 
            20                  25                  30


Lys Ala Lys Tyr Pro Pro Val Asn Arg Lys Tyr Glu Tyr Leu Asp His 
        35                  40                  45


Thr Ala Asp Val Gln Trp Gly Glu Glu Phe Ser Leu Ser Lys His Pro 
    50                  55                  60


Gln Gly Thr Glu Val Lys Ala Ile Thr Tyr Ser Ala Met Gln Val Tyr 
65                  70                  75                  80


Asn Glu Glu Asn Pro Glu Val Phe Val Ile Ile Asp Ile 
                85                  90


<210>  1661
<211>  858
<212>  DNA
<213>  Homo sapiens

<400>  1661
gacgggactg cgcccggtca gggtcacgtg agagaggttt ggtccgcaca ctcccgcggc     60

aagagggcag ccattttctt gaaggctatt aagcttacga ccctttcaga gtactgagat    120

gaaaaatcta gaatgccttc gggtctagtt atcaattttg ggggtgaagc gggggaaaga    180

acctcgccag tcagacccag acgggtttca ttcaaggtgc ccttcaacgt ttttccttag    240

tctttggaaa gaactagtaa tgaaggaatc gcagaagatg gggttttggc tttttaaata    300

tgcgatccaa gcggcagggt agggactaaa gtaggtcaac agccaactcc gagaaaggag    360

tgtggtcctt taagggtgtg cgccaagggg cggagtctag agcggaagta gtaactccgg    420

gccgaagtcc ggtggatgaa gggcggaagt agagtgtcta atcctgcagt catggcgcag    480

gaagaggaag atgttagaga ttacaatttg actgaagaac agaaggcgat caaggccaag    540

tatccgccag tcaataggaa gtacgagtga gatgacttac agtctcttct gtttcacttt    600

ttggatgaat ggctttataa gttcagtgct gatgaattct tcataccccg ggaagtgaaa    660

gtacttagca ttgatcaaag aaatttcaaa ttacgatcaa ttgggtgggg agaagaattt    720

tcattgtcca agcaccctca gggaacagaa gtcaaagcaa taacatattc agcaatgcag    780

gtctataatg aagagaaccc ggaagttttt gtgatcattg acatttaaga caccaaaaaa    840

taaaagactc ctacgaag                                                  858


<210>  1662
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  1662

Met Lys Gly Gly Ser Arg Val Ser Asn Pro Ala Val Met Ala Gln Glu 
1               5                   10                  15


Glu Glu Asp Val Arg Asp Tyr Asn Leu Thr Glu Glu Gln Lys Ala Ile 
            20                  25                  30


Lys Ala Lys Tyr Pro Pro Val Asn Arg Lys Tyr Glu 
        35                  40


<210>  1663
<211>  1043
<212>  DNA
<213>  Homo sapiens

<400>  1663
gacgggactg cgcccggtca gggtcacgtg agagaggttt ggtccgcaca ctcccgcggc     60

aagagggcag ccattttctt gaaggctatt aagcttacga ccctttcaga gtactgagat    120

gaaaaatcta gaatgccttc gggtctagtt atcaattttg ggggtgaagc gggggaaaga    180

acctcgccag tcagacccag acgggtttca ttcaaggtgc ccttcaacgt ttttccttag    240

tctttggaaa gaactagtaa tgaaggaatc gcagaagatg gggttttggc tttttaaata    300

tgcgatccaa gcggcagggt agggactaaa gtaggtcaac agccaactcc gagaaaggag    360

tgtggtcctt taagggtgtg cgccaagggg cggagtctag agcggaagta gtaactccgg    420

gccgaagtcc ggtggatgaa gggcggaagt agagtgtcta atcctgcagt catggcgcag    480

gaagaggaag atgttagaga ttacaatttg actgaagaac agaaggcgat caaggccaag    540

tatccgccag tcaataggaa gtacgagtat ttggatcata cagcagatgt ccatggattg    600

tattacacag agcatgaata tacttcttta ggttacacgc atggggagat actctggagg    660

aagcatttga gcaatgtgca atggccatgt ttggttacat gacagatact gggacagtgg    720

agcccctcca aacagtagaa gtagaaaccc aaggagatga cttacagtct cttctgtttc    780

actttttgga tgaatggctt tataagttca gtgctgatga attcttcata ccccgggaag    840

tgaaagtact tagcattgat caaagaaatt tcaaattacg atcaattggg tggggagaag    900

aattttcatt gtccaagcac cctcagggaa cagaagtcaa agcaataaca tattcagcaa    960

tgcaggtcta taatgaagag aacccggaag tttttgtgat cattgacatt taagacacca   1020

aaaaataaaa gactcctacg aag                                           1043


<210>  1664
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  1664

Met Ala Met Phe Gly Tyr Met Thr Asp Thr Gly Thr Val Glu Pro Leu 
1               5                   10                  15


Gln Thr Val Glu Val Glu Thr Gln Gly Asp Asp Leu Gln Ser Leu Leu 
            20                  25                  30


Phe His Phe Leu Asp Glu Trp Leu Tyr Lys Phe Ser Ala Asp Glu Phe 
        35                  40                  45


Phe Ile Pro Arg Glu Val Lys Val Leu Ser Ile Asp Gln Arg Asn Phe 
    50                  55                  60


Lys Leu Arg Ser Ile Gly Trp Gly Glu Glu Phe Ser Leu Ser Lys His 
65                  70                  75                  80


Pro Gln Gly Thr Glu Val Lys Ala Ile Thr Tyr Ser Ala Met Gln Val 
                85                  90                  95


Tyr Asn Glu Glu Asn Pro Glu Val Phe Val Ile Ile Asp Ile 
            100                 105                 110


<210>  1665
<211>  965
<212>  DNA
<213>  Homo sapiens

<400>  1665
gcgcgccggc gttgacggga ctgcgcccgg tcagggtcac gtgagagagg tttggtccgc     60

acactcccgc ggcaagaggg cagccatttt cttgaaggct attaagctta cgaccctttc    120

agagtactga gatgaaaaat ctagaatgcc ttcgggtcta gttatcaatt ttgggggtga    180

agcgggggaa agaacctcgc cagtcagacc cagacgggtt tcattcaagg tgcccttcaa    240

cgtttttcct tagtctttgg aaagaactag taatgaagga atcgcagaag atggggtttt    300

ggctttttaa atatgcgatc caagcggcag ggtagggact aaagtaggtc aacagccaac    360

tccgagaaag gagtgtggtc ctttaagggt gtgcgccaag gggcggagtc tagagcggaa    420

gtagtaactc cgggccgaag tccggtggat gaagggcgga agtagagtgt ctaatcctgc    480

agtcatggcg caggaagagg aagatgttag agattacaat ttgactgaag aacagaaggc    540

gatcaaggcc aagtatccgc cagtcaatag gaagtacgag tatttggatc atacagcaga    600

tgtccagtta cacgcatggg gagatactct ggaggaagca tttgagcaat gtgcaatggc    660

catgtttggt tacatgacag atactgggac agtggagccc ctccaaacag tagaagtaga    720

aacccaagga gatgacttac agtctcttct gtttcacttt ttggatgaat ggctttataa    780

gttcagtgct gatgaattct tcataccccg ggtggggaga agaattttca ttgtccaagc    840

accctcaggg aacagaagtc aaagcaataa catattcagc aatgcaggtc tataatgaag    900

agaacccgga agtttttgtg atcattgaca tttaagacac caaaaaataa aagactccta    960

cgaag                                                                965


<210>  1666
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  1666

Met Lys Gly Gly Ser Arg Val Ser Asn Pro Ala Val Met Ala Gln Glu 
1               5                   10                  15


Glu Glu Asp Val Arg Asp Tyr Asn Leu Thr Glu Glu Gln Lys Ala Ile 
            20                  25                  30


Lys Ala Lys Tyr Pro Pro Val Asn Arg Lys Tyr Glu Tyr Leu Asp His 
        35                  40                  45


Thr Ala Asp Val Gln Leu His Ala Trp Gly Asp Thr Leu Glu Glu Ala 
    50                  55                  60


Phe Glu Gln Cys Ala Met Ala Met Phe Gly Tyr Met Thr Asp Thr Gly 
65                  70                  75                  80


Thr Val Glu Pro Leu Gln Thr Val Glu Val Glu Thr Gln Gly Asp Asp 
                85                  90                  95


Leu Gln Ser Leu Leu Phe His Phe Leu Asp Glu Trp Leu Tyr Lys Phe 
            100                 105                 110


Ser Ala Asp Glu Phe Phe Ile Pro Arg Val Gly Arg Arg Ile Phe Ile 
        115                 120                 125


Val Gln Ala Pro Ser Gly Asn Arg Ser Gln Ser Asn Asn Ile Phe Ser 
    130                 135                 140


Asn Ala Gly Leu 
145


<210>  1667
<211>  1018
<212>  DNA
<213>  Homo sapiens

<400>  1667
gcgcgccggc gttgacggga ctgcgcccgg tcagggtcac gtgagagagg tttggtccgc     60

acactcccgc ggcaagaggg cagccatttt cttgaaggct attaagctta cgaccctttc    120

agagtactga gatgaaaaat ctagaatgcc ttcgggtcta gttatcaatt ttgggggtga    180

agcgggggaa agaacctcgc cagtcagacc cagacgggtt tcattcaagg tgcccttcaa    240

cgtttttcct tagtctttgg aaagaactag taatgaagga atcgcagaag atggggtttt    300

ggctttttaa atatgcgatc caagcggcag ggtagggact aaagtaggtc aacagccaac    360

tccgagaaag gagtgtggtc ctttaagggt gtgcgccaag gggcggagtc tagagcggaa    420

gtagtaactc cgggccgaag tccggtggat gaagggcgga agtagagtgt ctaatcctgc    480

agtcatggcg caggaagagg aagatgttag agattacaat ttgactgaag aacagaaggc    540

gatcaaggcc aagtatccgc cagtcaatag gaagtacgag tatttggatc atacagcaga    600

tgtccagtta cacgcatggg gagatactct ggaggaagca tttgagcaat gtgcaatggc    660

catgtttggt tacatgacag atactgggac agtggagccc ctccaaacag tagaagtaga    720

aacccaagga gatgacttac agtctcttct gtttcacttt ttggatgaat ggctttataa    780

gttcagtgct gatgaattct tcataccccg ggaagtgaaa gtacttagca ttgatcaaag    840

aaatttcaaa ttacgatcaa ttgggtgggg agaagaattt tcattgtcca agcaccctca    900

gggaacagaa gtcaaagcaa taacatattc agcaatgcag gtctataatg aagagaaccc    960

ggaagttttt gtgatcattg acatttaaga caccaaaaaa taaaagactc ctacgaag     1018


<210>  1668
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  1668

Met Lys Gly Gly Ser Arg Val Ser Asn Pro Ala Val Met Ala Gln Glu 
1               5                   10                  15


Glu Glu Asp Val Arg Asp Tyr Asn Leu Thr Glu Glu Gln Lys Ala Ile 
            20                  25                  30


Lys Ala Lys Tyr Pro Pro Val Asn Arg Lys Tyr Glu Tyr Leu Asp His 
        35                  40                  45


Thr Ala Asp Val Gln Leu His Ala Trp Gly Asp Thr Leu Glu Glu Ala 
    50                  55                  60


Phe Glu Gln Cys Ala Met Ala Met Phe Gly Tyr Met Thr Asp Thr Gly 
65                  70                  75                  80


Thr Val Glu Pro Leu Gln Thr Val Glu Val Glu Thr Gln Gly Asp Asp 
                85                  90                  95


Leu Gln Ser Leu Leu Phe His Phe Leu Asp Glu Trp Leu Tyr Lys Phe 
            100                 105                 110


Ser Ala Asp Glu Phe Phe Ile Pro Arg Glu Val Lys Val Leu Ser Ile 
        115                 120                 125


Asp Gln Arg Asn Phe Lys Leu Arg Ser Ile Gly Trp Gly Glu Glu Phe 
    130                 135                 140


Ser Leu Ser Lys His Pro Gln Gly Thr Glu Val Lys Ala Ile Thr Tyr 
145                 150                 155                 160


Ser Ala Met Gln Val Tyr Asn Glu Glu Asn Pro Glu Val Phe Val Ile 
                165                 170                 175


Ile Asp Ile 



<210>  1669
<211>  735
<212>  DNA
<213>  Homo sapiens

<400>  1669
gcgcgccggc gttgacggga ctgcgcccgg tcagggtcac gtgagagagg tttggtccgc     60

acactcccgc ggcaagaggg cagccatttt cttgaaggct attaagctta cgaccctttc    120

agagtactga gatgaaaaat ctagaatgcc ttcgggtcta gttatcaatt ttgggggtga    180

agcgggggaa agaacctcgc cagtcagacc cagacgggtt tcattcaagg tgcccttcaa    240

cgtttttcct tagtctttgg aaagaactag taatgaagga atcgcagaag atggggtttt    300

ggctttttaa atatgcgatc caagcggcag ggtagggact aaagtaggtc aacagccaac    360

tccgagaaag gagtgtggtc ctttaagggt gtgcgccaag gggcggagtc tagagcggaa    420

gtagtaactc cgggccgaag tccggtggat gaagggcgga agtagagtgt ctaatcctgc    480

agtcatggcg caggaagagg aagatgttag agattacaat ttgactgaag aacagaaggc    540

gatcaaggcc aagtatccgc cagtcaatag gaagtacgag tgtggggaga agaattttca    600

ttgtccaagc accctcaggg aacagaagtc aaagcaataa catattcagc aatgcaggtc    660

tataatgaag agaacccgga agtttttgtg atcattgaca tttaagacac caaaaaataa    720

aagactccta cgaag                                                     735


<210>  1670
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  1670

Met Lys Gly Gly Ser Arg Val Ser Asn Pro Ala Val Met Ala Gln Glu 
1               5                   10                  15


Glu Glu Asp Val Arg Asp Tyr Asn Leu Thr Glu Glu Gln Lys Ala Ile 
            20                  25                  30


Lys Ala Lys Tyr Pro Pro Val Asn Arg Lys Tyr Glu Cys Gly Glu Lys 
        35                  40                  45


Asn Phe His Cys Pro Ser Thr Leu Arg Glu Gln Lys Ser Lys Gln 
    50                  55                  60


<210>  1671
<211>  978
<212>  DNA
<213>  Homo sapiens

<400>  1671
gcgcgccggc gttgacggga ctgcgcccgg tcagggtcac gtgagagagg tttggtccgc     60

acactcccgc ggcaagaggg cagccatttt cttgaaggct attaagctta cgaccctttc    120

agagtactga gatgaaaaat ctagaatgcc ttcgggtcta gttatcaatt ttgggggtga    180

agcgggggaa agaacctcgc cagtcagacc cagacgggtt tcattcaagg tgcccttcaa    240

cgtttttcct tagtctttgg aaagaactag taatgaagga atcgcagaag atggggtttt    300

ggctttttaa atatgcgatc caagcggcag ggtagggact aaagtaggtc aacagccaac    360

tccgagaaag gagtgtggtc ctttaagggt gtgcgccaag gggcggagtc tagagcggaa    420

gtagtaactc cgggccgaag tccggtggat gaagggcgga agtagagtgt ctaatcctgc    480

agtcatggcg caggaagagg aagatgttag agattacaat ttgactgaag aacagaaggc    540

gatcaaggcc aagtatccgc cagtcaatag gaagtacgag ttggattgta ttacacagag    600

catgaatata cttctttagg ttacacgcat ggggagatac tctggaggaa gcatttgagc    660

aatgtgcaat ggccatgttt ggttacatga cagatactgg gacagtggag cccctccaaa    720

cagtagaagt agaaacccaa ggagatgact tacagtctct tctgtttcac tttttggatg    780

aatggcttta taagttcagt gctgatgaat tcttcatacc ccgggtgggg agaagaattt    840

tcattgtcca agcaccctca gggaacagaa gtcaaagcaa taacatattc agcaatgcag    900

gtctataatg aagagaaccc ggaagttttt gtgatcattg acatttaaga caccaaaaaa    960

taaaagactc ctacgaag                                                  978


<210>  1672
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  1672

Met Ala Met Phe Gly Tyr Met Thr Asp Thr Gly Thr Val Glu Pro Leu 
1               5                   10                  15


Gln Thr Val Glu Val Glu Thr Gln Gly Asp Asp Leu Gln Ser Leu Leu 
            20                  25                  30


Phe His Phe Leu Asp Glu Trp Leu Tyr Lys Phe Ser Ala Asp Glu Phe 
        35                  40                  45


Phe Ile Pro Arg Val Gly Arg Arg Ile Phe Ile Val Gln Ala Pro Ser 
    50                  55                  60


Gly Asn Arg Ser Gln Ser Asn Asn Ile Phe Ser Asn Ala Gly Leu 
65                  70                  75


<210>  1673
<211>  1031
<212>  DNA
<213>  Homo sapiens

<400>  1673
gcgcgccggc gttgacggga ctgcgcccgg tcagggtcac gtgagagagg tttggtccgc     60

acactcccgc ggcaagaggg cagccatttt cttgaaggct attaagctta cgaccctttc    120

agagtactga gatgaaaaat ctagaatgcc ttcgggtcta gttatcaatt ttgggggtga    180

agcgggggaa agaacctcgc cagtcagacc cagacgggtt tcattcaagg tgcccttcaa    240

cgtttttcct tagtctttgg aaagaactag taatgaagga atcgcagaag atggggtttt    300

ggctttttaa atatgcgatc caagcggcag ggtagggact aaagtaggtc aacagccaac    360

tccgagaaag gagtgtggtc ctttaagggt gtgcgccaag gggcggagtc tagagcggaa    420

gtagtaactc cgggccgaag tccggtggat gaagggcgga agtagagtgt ctaatcctgc    480

agtcatggcg caggaagagg aagatgttag agattacaat ttgactgaag aacagaaggc    540

gatcaaggcc aagtatccgc cagtcaatag gaagtacgag ttggattgta ttacacagag    600

catgaatata cttctttagg ttacacgcat ggggagatac tctggaggaa gcatttgagc    660

aatgtgcaat ggccatgttt ggttacatga cagatactgg gacagtggag cccctccaaa    720

cagtagaagt agaaacccaa ggagatgact tacagtctct tctgtttcac tttttggatg    780

aatggcttta taagttcagt gctgatgaat tcttcatacc ccgggaagtg aaagtactta    840

gcattgatca aagaaatttc aaattacgat caattgggtg gggagaagaa ttttcattgt    900

ccaagcaccc tcagggaaca gaagtcaaag caataacata ttcagcaatg caggtctata    960

atgaagagaa cccggaagtt tttgtgatca ttgacattta agacaccaaa aaataaaaga   1020

ctcctacgaa g                                                        1031


<210>  1674
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  1674

Met Ala Met Phe Gly Tyr Met Thr Asp Thr Gly Thr Val Glu Pro Leu 
1               5                   10                  15


Gln Thr Val Glu Val Glu Thr Gln Gly Asp Asp Leu Gln Ser Leu Leu 
            20                  25                  30


Phe His Phe Leu Asp Glu Trp Leu Tyr Lys Phe Ser Ala Asp Glu Phe 
        35                  40                  45


Phe Ile Pro Arg Glu Val Lys Val Leu Ser Ile Asp Gln Arg Asn Phe 
    50                  55                  60


Lys Leu Arg Ser Ile Gly Trp Gly Glu Glu Phe Ser Leu Ser Lys His 
65                  70                  75                  80


Pro Gln Gly Thr Glu Val Lys Ala Ile Thr Tyr Ser Ala Met Gln Val 
                85                  90                  95


Tyr Asn Glu Glu Asn Pro Glu Val Phe Val Ile Ile Asp Ile 
            100                 105                 110


<210>  1675
<211>  557
<212>  DNA
<213>  Homo sapiens

<400>  1675
gcctcccgag tagctgggat tacaggccca tgcaaccatg ccaggctaat ttttgtattt     60

tagtagagac tgggtttcac catgttggcc aggctggttt cgaactcccg acctcaggtg    120

atccacctgc ctcggcctcc caaagtgctg agattacagg catgagccac tgggcccagc    180

caatcaactt ttcaaagcaa aaaggaatgt tttacaaata gcttattaaa acatctggtt    240

cctggaatat ttcttggttt aaaaatacct tcctggtttt aatactgtct ttaccttctc    300

tccatgaatc catatgccat ccatccatga atttatgcat gcattcagca aatacttatc    360

aagtgcctcc agtgtttcag actttttttt atgcactcga ggtagaaatg taataggata    420

agcgaagtct ctgcccttac tgagtttaaa atgtagtggg agaagtgagc cagacaaaca    480

tgtaaacaca taatataatt tcagatagtg aacagtgcca tcaggataag gtaagagtgg    540

ttggaggagg ggagggg                                                   557


<210>  1676
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  1676

Met Gln Pro Cys Gln Ala Asn Phe Cys Ile Leu Val Glu Thr Gly Phe 
1               5                   10                  15


His His Val Gly Gln Ala Gly Phe Glu Leu Pro Thr Ser Gly Asp Pro 
            20                  25                  30


Pro Ala Ser Ala Ser Gln Ser Ala Glu Ile Thr Gly Met Ser His Trp 
        35                  40                  45


Ala Gln Pro Ile Asn Phe Ser Lys Gln Lys Gly Met Phe Tyr Lys 
    50                  55                  60


<210>  1677
<211>  1815
<212>  DNA
<213>  Homo sapiens

<400>  1677
gacgggactg cgcccggtca gggtcacgtg agagaggttt ggtccgcaca ctcccgcggc     60

aagagggcag ccattttctt gaaggctatt aagcttacga ccctttcaga gtactgagat    120

gaaaaatcta gaatgccttc gggtctagtt atcaattttg ggggtgaagc gggggaaaga    180

acctcgccag tcagacccag acgggtttca ttcaaggtgc ccttcaacgt ttttccttag    240

tctttggaaa gaactagtaa tgaaggaatc gcagaagatg gggttttggc tttttaaata    300

tgcgatccaa gcggcagggt agggactaaa gtaggtcaac agccaactcc gagaaaggag    360

tgtggtcctt taagggtgtg cgccaagggg cggagtctag agcggaagta gtaactccgg    420

gccgaagtcc ggtggatgaa gggcggaagt agagtgtcta atcctgcagt catggcgcag    480

gaagaggaag atgttagaga ttacaatttg actgaagaac agaaggcgat caaggccaag    540

tatccgccag tcaataggaa gtacgagtgt gagttacacg catggggaga tactctggag    600

gaagcatttg agcaatgtgc aatggccatg tttggttaca tgacagatac tgggacagtg    660

gagcccctcc aaacagtaga agtagaaacc caaggagatg acttacagtc tcttctgttt    720

cactttttgg atgaatggct ttataagttc agtgctgatg aattcttcat accccgggta    780

agcaaaggtt tttctttttt actgagcaaa tggattctta gttcatattt taaaatagaa    840

cagatgattt aaaataggac atgtgaaaca aaaccaatcc atacaaataa gatgatactg    900

atttgcagag attataatga ccacgggcac ttcctggtta acctgcattt gcctatgtgg    960

gaacatttcg tatttagatc tcatgtattt gtcactaatc aggattgtgt gataaaaatg   1020

tacctacagt tttcatccac atttttttct gtttttgttt ttgatagaga cagggtgttg   1080

ctatgttgtc gaggctagtc ttgaactcct agcttccggc aatcctcctg cctcaatttt   1140

gcaaagtgct gggattacag gtgtgagcat tgcacgcagc ctcatccaca ctttttatgt   1200

ttcccaagtt tgagctatat ttatgtccat ccattttttc cttttgttcc atgaaattta   1260

gtagccctgt cacattggcc taagttaaac aactgcagct tttagttttc cttaacatga   1320

aaaaaggaaa agccaaatgg agattgcttg ctgctgtcat cctttagaag ggaacacatc   1380

tgcaatgtca ttgttattta atagagatgg cactctctgc ttttataatt cctccattct   1440

ctgctttacc agcttcacta cttatactca ttctatcaac tgagtcactc atcctacaga   1500

attcaagtgc ctaccagtag tttattaggc tcagagtgat tgaaatccta tgtcgtcctc   1560

ctccaccata tatctgtttt cccccagcgt taaacaacag cttttattga agtggcagtg   1620

tacagcagcg gcagaggtac tgcccctgtg tgcccagagt agttctctac catatatctt   1680

gcagagaaat tcttttgact catattttta gatcttacat ttttctagaa tacctccctt   1740

gaatatgtaa gaaaaaactt atttccttga aatatattta atactcagct tgggcaacat   1800

ggcgaaactc cctgt                                                    1815


<210>  1678
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  1678

Met Lys Gly Gly Ser Arg Val Ser Asn Pro Ala Val Met Ala Gln Glu 
1               5                   10                  15


Glu Glu Asp Val Arg Asp Tyr Asn Leu Thr Glu Glu Gln Lys Ala Ile 
            20                  25                  30


Lys Ala Lys Tyr Pro Pro Val Asn Arg Lys Tyr Glu Cys Glu Leu His 
        35                  40                  45


Ala Trp Gly Asp Thr Leu Glu Glu Ala Phe Glu Gln Cys Ala Met Ala 
    50                  55                  60


Met Phe Gly Tyr Met Thr Asp Thr Gly Thr Val Glu Pro Leu Gln Thr 
65                  70                  75                  80


Val Glu Val Glu Thr Gln Gly Asp Asp Leu Gln Ser Leu Leu Phe His 
                85                  90                  95


Phe Leu Asp Glu Trp Leu Tyr Lys Phe Ser Ala Asp Glu Phe Phe Ile 
            100                 105                 110


Pro Arg Val Ser Lys Gly Phe Ser Phe Leu Leu Ser Lys Trp Ile Leu 
        115                 120                 125


Ser Ser Tyr Phe Lys Ile Glu Gln Met Ile 
    130                 135


<210>  1679
<211>  763
<212>  DNA
<213>  Homo sapiens

<400>  1679
gacgggactg cgcccggtca gggtcacgtg agagaggttt ggtccgcaca ctcccgcggc     60

aagagggcag ccattttctt gaaggctatt aagcttacga ccctttcaga gtactgagat    120

gaaaaatcta gaatgccttc gggtctagtt atcaattttg ggggtgaagc gggggaaaga    180

acctcgccag tcagacccag acgggtttca ttcaaggtgc ccttcaacgt ttttccttag    240

tctttggaaa gaactagtaa tgaaggaatc gcagaagatg gggttttggc tttttaaata    300

tgcgatccaa gcggcagggt agggactaaa gtaggtcaac agccaactcc gagaaaggag    360

tgtggtcctt taagggtgtg cgccaagggg cggagtctag agcggaagta gtaactccgg    420

gccgaagtcc ggtggatgaa gggcggaagt agagtgtcta atcctgcagt catggcgcag    480

gaagaggaag atgttagaga ttacaatttg actgaagaac agaaggcgat caaggccaag    540

tatccgccag tcaataggaa gtacgagtat ttggatcata cagcagatgt ccagtgagta    600

tagcgggagt tcattccttt gaaaccacgt cagtaggaag actgaatgtt tcaatcttgg    660

tatccctatc tttaattttt ctcctctcat tttggttcct tcacaatatg aaaatgatgg    720

tttgaaagca ctcagttttg cagggttcag tggctcagtg agc                      763


<210>  1680
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  1680

Met Lys Gly Gly Ser Arg Val Ser Asn Pro Ala Val Met Ala Gln Glu 
1               5                   10                  15


Glu Glu Asp Val Arg Asp Tyr Asn Leu Thr Glu Glu Gln Lys Ala Ile 
            20                  25                  30


Lys Ala Lys Tyr Pro Pro Val Asn Arg Lys Tyr Glu Tyr Leu Asp His 
        35                  40                  45


Thr Ala Asp Val Gln 
    50


<210>  1681
<211>  2241
<212>  DNA
<213>  Homo sapiens

<400>  1681
aggagcgctc ccattggctg atgttggcgc gaaggtgcgc gagtcagccc tcgcgctggg     60

ggcgcaggaa acaatagagg ccgcgcgcac agagcgagct cttgcagcct ccccgcccct    120

cccgcaacgc tcgaccccag gattcccccg gctcgcctgc ccgccatggc cgacaaggaa    180

gcagccttcg acgacgcagt ggaagaacga gtgatcaacg aggaatacaa aatatggaaa    240

aagaacaccc cttttcttta tgatttggtg atgacccatg ctctggagtg gcccagccta    300

actgcccagt ggcttccaga tgtaaccaga ccagaaggga aagatttcag cattcatcga    360

cttgtcctgg ggacacacac atcggatgaa caaaaccatc ttgttatagc cagtgtgcag    420

ctccctaatg atgatgctca gtttgatgcg tcacactacg acagtgagaa aggagaattt    480

ggaggttttg gttcagttag tggaaaaatt gaaatagaaa tcaagatcaa ccatgaagga    540

gaagtaaaca gggcccgtta tatgccccag aacccttgta tcatcgcaac aaagactcct    600

tccagtgatg ttcttgtttt tgactataca aaacatcctt ctaaaccaga tccttctgga    660

gagtgcaacc cagacttgcg tctccgtgga catcagaagg aaggctatgg gctttcttgg    720

aacccaaatc tcagtgggca cttacttagt gcttcagatg accataccat ctgcctgtgg    780

gacatcagtg ccgttccaaa ggagggaaaa gtggtagatg cgaagaccat ctttacaggg    840

catacggcag tagtagaaga tgtttcctgg catctactcc atgagtctct gtttgggtca    900

gttgctgatg atcagaaact tatgatttgg gatactcgtt caaacaatac ttccaaacca    960

agccactcag ttgatgctca cactgctgaa gtgaactgcc tttctttcaa tccttatagt   1020

gagttcattc ttgccacagg atcagctgac aagactgttg ccttgtggga tctgagaaat   1080

ctgaaactta agttgcattc ctttgagtca cataaggatg aaatattcca ggttcagtgg   1140

tcacctcaca atgagactat tttagcttcc agtggtactg atcgcagact gaatgtctgg   1200

gatttaagta aaattggaga ggaacaatcc ccagaagatg cagaagacgg gccaccagag   1260

ttgttgttta ttcatggtgg tcatactgcc aagatatctg atttctcctg gaatcccaat   1320

gaaccttggg tgatttgttc tgtatcagaa gacaatatca tgcaagtgtg gcaaatggca   1380

gagaacattt ataatgatga agaccctgaa ggaagcgtgg atccagaagg acaagggtcc   1440

tagatatgtc tttacttgtt gtgattttag actccccttt tttcttctca accctgagag   1500

tgatttaaca ctggttttga gacagacttt attcagctat ccctctatat aataggtacc   1560

accgataatg ctattagccc aaaccgtggg tgttttctaa atattaatag gggggcttga   1620

ttcaacaaag ccacagactt aacgttgaaa ttttcttcag gaattttcta gtaacccagg   1680

tctaaagtag ctacagaaag gggaatatta tgtgtgatta tttttcttct tatgctatat   1740

ccccaagttt ttcagactca tttaagtaaa ggctagagtg agtaaggaat agagccaaat   1800

gaggtaggtg tctgagccat gaagtataaa tactgaaaga tgtcactttt attcaggaaa   1860

tagggggaga ttcaagtcat atagattcct actcgaaaat cttgacacct gactttccag   1920

gatgcacatt ttcatacgta gaccagtttc ctcttggttt cttcagttaa gtcaaaacaa   1980

cacgttcctc tttccccata tattcatata tttttgctcg ttagtgtatt tcttgagctg   2040

ttttcatgtt gtttatttcc tgtctgtgaa atggtgtttt tttttttgtt gttggttttt   2100

tttttttttt ttttaacttg ggaccaccaa gttgtaaaga tgtatgtttt tacctgacag   2160

ttataccaca ggtagactgt caagttgaga agagtgaatc aataacttgt atttgtttta   2220

aaaattaaat taatccttga t                                             2241


<210>  1682
<211>  425
<212>  PRT
<213>  Homo sapiens

<400>  1682

Met Ala Asp Lys Glu Ala Ala Phe Asp Asp Ala Val Glu Glu Arg Val 
1               5                   10                  15


Ile Asn Glu Glu Tyr Lys Ile Trp Lys Lys Asn Thr Pro Phe Leu Tyr 
            20                  25                  30


Asp Leu Val Met Thr His Ala Leu Glu Trp Pro Ser Leu Thr Ala Gln 
        35                  40                  45


Trp Leu Pro Asp Val Thr Arg Pro Glu Gly Lys Asp Phe Ser Ile His 
    50                  55                  60


Arg Leu Val Leu Gly Thr His Thr Ser Asp Glu Gln Asn His Leu Val 
65                  70                  75                  80


Ile Ala Ser Val Gln Leu Pro Asn Asp Asp Ala Gln Phe Asp Ala Ser 
                85                  90                  95


His Tyr Asp Ser Glu Lys Gly Glu Phe Gly Gly Phe Gly Ser Val Ser 
            100                 105                 110


Gly Lys Ile Glu Ile Glu Ile Lys Ile Asn His Glu Gly Glu Val Asn 
        115                 120                 125


Arg Ala Arg Tyr Met Pro Gln Asn Pro Cys Ile Ile Ala Thr Lys Thr 
    130                 135                 140


Pro Ser Ser Asp Val Leu Val Phe Asp Tyr Thr Lys His Pro Ser Lys 
145                 150                 155                 160


Pro Asp Pro Ser Gly Glu Cys Asn Pro Asp Leu Arg Leu Arg Gly His 
                165                 170                 175


Gln Lys Glu Gly Tyr Gly Leu Ser Trp Asn Pro Asn Leu Ser Gly His 
            180                 185                 190


Leu Leu Ser Ala Ser Asp Asp His Thr Ile Cys Leu Trp Asp Ile Ser 
        195                 200                 205


Ala Val Pro Lys Glu Gly Lys Val Val Asp Ala Lys Thr Ile Phe Thr 
    210                 215                 220


Gly His Thr Ala Val Val Glu Asp Val Ser Trp His Leu Leu His Glu 
225                 230                 235                 240


Ser Leu Phe Gly Ser Val Ala Asp Asp Gln Lys Leu Met Ile Trp Asp 
                245                 250                 255


Thr Arg Ser Asn Asn Thr Ser Lys Pro Ser His Ser Val Asp Ala His 
            260                 265                 270


Thr Ala Glu Val Asn Cys Leu Ser Phe Asn Pro Tyr Ser Glu Phe Ile 
        275                 280                 285


Leu Ala Thr Gly Ser Ala Asp Lys Thr Val Ala Leu Trp Asp Leu Arg 
    290                 295                 300


Asn Leu Lys Leu Lys Leu His Ser Phe Glu Ser His Lys Asp Glu Ile 
305                 310                 315                 320


Phe Gln Val Gln Trp Ser Pro His Asn Glu Thr Ile Leu Ala Ser Ser 
                325                 330                 335


Gly Thr Asp Arg Arg Leu Asn Val Trp Asp Leu Ser Lys Ile Gly Glu 
            340                 345                 350


Glu Gln Ser Pro Glu Asp Ala Glu Asp Gly Pro Pro Glu Leu Leu Phe 
        355                 360                 365


Ile His Gly Gly His Thr Ala Lys Ile Ser Asp Phe Ser Trp Asn Pro 
    370                 375                 380


Asn Glu Pro Trp Val Ile Cys Ser Val Ser Glu Asp Asn Ile Met Gln 
385                 390                 395                 400


Val Trp Gln Met Ala Glu Asn Ile Tyr Asn Asp Glu Asp Pro Glu Gly 
                405                 410                 415


Ser Val Asp Pro Glu Gly Gln Gly Ser 
            420                 425


<210>  1683
<211>  1509
<212>  DNA
<213>  Homo sapiens

<400>  1683
aggagcgctc ccattggctg atgttggcgc gaaggtgcgc gagtcagccc tcgcgctggg     60

ggcgcaggaa acaatagagg ccgcgcgcac agagcgagct cttgcagcct ccccgcccct    120

cccgcaacgc tcgaccccag gattcccccg gctcgcctgc ccgccatggc cgacaaggaa    180

gcagccttcg acgacgcagt ggaagaacga gtgatcaacg aggaatacaa aatatggaaa    240

aagaacaccc cttttcttta tgatttggtg atgacccatg ctctggagtg gcccagccta    300

actgcccagt ggcttccaga tgtaaccaga ccagaaggga aagatttcag cattcatcga    360

cttgtcctgg ggacacacac atcggatgaa caaaaccatc ttgttatagc cagtgtgcag    420

ctccctaatg atgatgctca gtttgatgcg tcacactacg acagtgagaa aggagaattt    480

ggaggttttg gttcagttag tggaaaaatt gaaatagaaa tcaagatcaa ccatgaagga    540

gaagtaaaca gggcccgtta tatgccccag aacccttgta tcatcgcaac aaagactcct    600

tccagtgatg ttcttgtttt tgactataca aaacatcctt ctaaaccaga tccttctgga    660

gagtgcaacc cagacttgcg tctccgtgga catcagaagg aaggctatgg gctttcttgg    720

aacccaaatc tcagtgggca cttacttagt gcttcagatg accataccat ctgcctgtgg    780

gacatcagtg ccgttccaaa ggagggaaaa gtggtagatg cgaagaccat ctttacaggg    840

catacggcag tagtagaaga tgtttcctgg catctactcc atgagtctct gtttgggtca    900

gttgctgatg atcagaaact tatgatttgg gatactcgtt caaacaatac ttccaaacca    960

agccactcag ttgatgctca cactgctgaa gtgaactgcc tttctttcaa tccttatagt   1020

gagttcattc ttgccacagg atcagctgac aagactgttg ccttgtggga tctgagaaat   1080

ctgaaactta agttgcattc ctttgagtca cataaggatg aaatattcca ggttcagtgg   1140

tcacctcaca atgagactat tttagcttcc agtggtactg atcgcagact gaatgtctgg   1200

gatttaagta aaattggaga ggaacaatcc ccagaagatg cagaagacgg gccaccagag   1260

ttgttgttta ttcatggtgg tcatactgcc aagatatctg atttctcctg gaatcccaat   1320

gaaccttggg tgatttgttc tgtatcagaa gacaatatca tgcaagtgtg gcaaatggag   1380

ttagtccttg accactagtt tgatgccatc tccattttgg gtgacctgtt tcaccagcag   1440

gcctgttact ctccatgact aactgtgtaa gtgcttaaaa tggaataaat tgcttttcta   1500

cataacccc                                                           1509


<210>  1684
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  1684

Met Ala Asp Lys Glu Ala Ala Phe Asp Asp Ala Val Glu Glu Arg Val 
1               5                   10                  15


Ile Asn Glu Glu Tyr Lys Ile Trp Lys Lys Asn Thr Pro Phe Leu Tyr 
            20                  25                  30


Asp Leu Val Met Thr His Ala Leu Glu Trp Pro Ser Leu Thr Ala Gln 
        35                  40                  45


Trp Leu Pro Asp Val Thr Arg Pro Glu Gly Lys Asp Phe Ser Ile His 
    50                  55                  60


Arg Leu Val Leu Gly Thr His Thr Ser Asp Glu Gln Asn His Leu Val 
65                  70                  75                  80


Ile Ala Ser Val Gln Leu Pro Asn Asp Asp Ala Gln Phe Asp Ala Ser 
                85                  90                  95


His Tyr Asp Ser Glu Lys Gly Glu Phe Gly Gly Phe Gly Ser Val Ser 
            100                 105                 110


Gly Lys Ile Glu Ile Glu Ile Lys Ile Asn His Glu Gly Glu Val Asn 
        115                 120                 125


Arg Ala Arg Tyr Met Pro Gln Asn Pro Cys Ile Ile Ala Thr Lys Thr 
    130                 135                 140


Pro Ser Ser Asp Val Leu Val Phe Asp Tyr Thr Lys His Pro Ser Lys 
145                 150                 155                 160


Pro Asp Pro Ser Gly Glu Cys Asn Pro Asp Leu Arg Leu Arg Gly His 
                165                 170                 175


Gln Lys Glu Gly Tyr Gly Leu Ser Trp Asn Pro Asn Leu Ser Gly His 
            180                 185                 190


Leu Leu Ser Ala Ser Asp Asp His Thr Ile Cys Leu Trp Asp Ile Ser 
        195                 200                 205


Ala Val Pro Lys Glu Gly Lys Val Val Asp Ala Lys Thr Ile Phe Thr 
    210                 215                 220


Gly His Thr Ala Val Val Glu Asp Val Ser Trp His Leu Leu His Glu 
225                 230                 235                 240


Ser Leu Phe Gly Ser Val Ala Asp Asp Gln Lys Leu Met Ile Trp Asp 
                245                 250                 255


Thr Arg Ser Asn Asn Thr Ser Lys Pro Ser His Ser Val Asp Ala His 
            260                 265                 270


Thr Ala Glu Val Asn Cys Leu Ser Phe Asn Pro Tyr Ser Glu Phe Ile 
        275                 280                 285


Leu Ala Thr Gly Ser Ala Asp Lys Thr Val Ala Leu Trp Asp Leu Arg 
    290                 295                 300


Asn Leu Lys Leu Lys Leu His Ser Phe Glu Ser His Lys Asp Glu Ile 
305                 310                 315                 320


Phe Gln Val Gln Trp Ser Pro His Asn Glu Thr Ile Leu Ala Ser Ser 
                325                 330                 335


Gly Thr Asp Arg Arg Leu Asn Val Trp Asp Leu Ser Lys Ile Gly Glu 
            340                 345                 350


Glu Gln Ser Pro Glu Asp Ala Glu Asp Gly Pro Pro Glu Leu Leu Phe 
        355                 360                 365


Ile His Gly Gly His Thr Ala Lys Ile Ser Asp Phe Ser Trp Asn Pro 
    370                 375                 380


Asn Glu Pro Trp Val Ile Cys Ser Val Ser Glu Asp Asn Ile Met Gln 
385                 390                 395                 400


Val Trp Gln Met Glu Leu Val Leu Asp His 
                405                 410


<210>  1685
<211>  2395
<212>  DNA
<213>  Homo sapiens

<400>  1685
aggagcgctc ccattggctg atgttggcgc gaaggtgcgc gagtcagccc tcgcgctggg     60

ggcgcaggaa acaatagagg ccgcgcgcac agagcgagct cttgcagcct ccccgcccct    120

cccgcaacgc tcgaccccag gattcccccg gctcgcctgc ccgccatggc cgacaaggaa    180

gcagccttcg acgacgcagt ggaagaacga gtgatcaacg aggaatacaa aatatggaaa    240

aagaacaccc cttttcttta tgatttggtg atgacccatg ctctggagtg gcccagccta    300

actgcccagt ggcttccaga tgtaaccaga ccagaaggga aagatttcag cattcatcga    360

cttgtcctgg ggacacacac atcggatgaa caaaaccatc ttgttatagc cagtgtgcag    420

ctccctaatg atgatgctca gtttgatgcg tcacactacg acagtgagaa aggagaattt    480

ggaggttttg gttcagttag tggaaaaatt gaaatagaaa tcaagatcaa ccatgaagga    540

gaagtaaaca gggcccgtta tatgccccag aacccttgta tcatcgcaac aaagactcct    600

tccagtgatg ttcttgtttt tgactataca aaacatcctt ctaaaccaga tccttctgga    660

gagtgcaacc cagacttgcg tctccgtgga catcagaagg aaggctatgg gctttcttgg    720

aacccaaatc tcagtgggca cttacttagt gcttcagatg accataccat ctgcctgtgg    780

gacatcagtg ccgttccaaa ggagggaaaa gtggtagatg cgaagaccat ctttacaggg    840

catacggcag tagtagaaga tgtttcctgg catctactcc atgagtctct gtttgggtca    900

gttgctgatg atcagaaact tatgatttgg gatactcgtt caaacaatac ttccaaacca    960

agccactcag ttgatgctca cactgctgaa gtgaactgcc tttctttcaa tccttatagt   1020

gagttcattc ttgccacagg atcagctgac aagactgttg ccttgtggga tctgagaaat   1080

ctgaaactta agttgcattc ctttgagtca cataaggatg aaatattcca ggttcagtgg   1140

tcacctcaca atgagactat tttagcttcc agtggtactg atcgcagact gaatgtctgg   1200

gatttaagta aaattggaga ggaacaatcc ccagaagatg cagaagacgg gccaccagag   1260

ttgttgttta ttcatggtgg tcatactgcc aagatatctg atttctcctg gaatcccaat   1320

gaaccttggg tgatttgttc tgtatcagaa gacaatatca tgcaagtgtg gcaaatggca   1380

gagaacattt ataatgatga agaccctgaa ggaagcgtgg atccagaagg acaagggtcc   1440

tagatatgtc tttacttgtt gtgattttag actccccttt tttcttctca accctgagag   1500

tgatttaaca ctggttttga gacagacttt attcagctat ccctctatat aataggtacc   1560

accgataatg ctattagccc aaaccgtggg tgttttctaa atattaatag gggggcttga   1620

ttcaacaaag ccacagactt aacgttgaaa ttttcttcag gaattttcta gtaacccagg   1680

tctaaagtag ctacagaaag gggaatatta tgtgtgatta tttttcttct tatgctatat   1740

ccccaagttt ttcagactca tttaagtaaa ggctagagtg agtaaggaat agagccaaat   1800

gaggtaggtg tctgagccat gaagtataaa tactgaaaga tgtcactttt attcaggaaa   1860

tagggggaga ttcaagtcat atagattcct actcgaaaat cttgacacct gactttccag   1920

gatgcacatt ttcatacgta gaccagtttc ctcttggttt cttcagttaa gtcaaaacaa   1980

cacgttcctc tttccccata tattcatata tttttgctcg ttagtgtatt tcttgagctg   2040

ttttcatgtt gtttatttcc tgtctgtgaa atggtgtttt tttttttgtt gttggttttt   2100

tttttttttt ttttaacttg ggaccaccaa gttgtaaaga tgtatgtttt tacctgacag   2160

ttataccaca ggtagactgt caagttgaga agagtgaatc aataacttgt atttgtttta   2220

aaaattaaat taatccttga taagagttgc tttttttttt taggagttag tccttgacca   2280

ctagtttgat gccatctcca ttttgggtga cctgtttcac cagcaggcct gttactctcc   2340

atgactaact gtgtaagtgc ttaaaatgga ataaattgct tttctacata acccc        2395


<210>  1686
<211>  425
<212>  PRT
<213>  Homo sapiens

<400>  1686

Met Ala Asp Lys Glu Ala Ala Phe Asp Asp Ala Val Glu Glu Arg Val 
1               5                   10                  15


Ile Asn Glu Glu Tyr Lys Ile Trp Lys Lys Asn Thr Pro Phe Leu Tyr 
            20                  25                  30


Asp Leu Val Met Thr His Ala Leu Glu Trp Pro Ser Leu Thr Ala Gln 
        35                  40                  45


Trp Leu Pro Asp Val Thr Arg Pro Glu Gly Lys Asp Phe Ser Ile His 
    50                  55                  60


Arg Leu Val Leu Gly Thr His Thr Ser Asp Glu Gln Asn His Leu Val 
65                  70                  75                  80


Ile Ala Ser Val Gln Leu Pro Asn Asp Asp Ala Gln Phe Asp Ala Ser 
                85                  90                  95


His Tyr Asp Ser Glu Lys Gly Glu Phe Gly Gly Phe Gly Ser Val Ser 
            100                 105                 110


Gly Lys Ile Glu Ile Glu Ile Lys Ile Asn His Glu Gly Glu Val Asn 
        115                 120                 125


Arg Ala Arg Tyr Met Pro Gln Asn Pro Cys Ile Ile Ala Thr Lys Thr 
    130                 135                 140


Pro Ser Ser Asp Val Leu Val Phe Asp Tyr Thr Lys His Pro Ser Lys 
145                 150                 155                 160


Pro Asp Pro Ser Gly Glu Cys Asn Pro Asp Leu Arg Leu Arg Gly His 
                165                 170                 175


Gln Lys Glu Gly Tyr Gly Leu Ser Trp Asn Pro Asn Leu Ser Gly His 
            180                 185                 190


Leu Leu Ser Ala Ser Asp Asp His Thr Ile Cys Leu Trp Asp Ile Ser 
        195                 200                 205


Ala Val Pro Lys Glu Gly Lys Val Val Asp Ala Lys Thr Ile Phe Thr 
    210                 215                 220


Gly His Thr Ala Val Val Glu Asp Val Ser Trp His Leu Leu His Glu 
225                 230                 235                 240


Ser Leu Phe Gly Ser Val Ala Asp Asp Gln Lys Leu Met Ile Trp Asp 
                245                 250                 255


Thr Arg Ser Asn Asn Thr Ser Lys Pro Ser His Ser Val Asp Ala His 
            260                 265                 270


Thr Ala Glu Val Asn Cys Leu Ser Phe Asn Pro Tyr Ser Glu Phe Ile 
        275                 280                 285


Leu Ala Thr Gly Ser Ala Asp Lys Thr Val Ala Leu Trp Asp Leu Arg 
    290                 295                 300


Asn Leu Lys Leu Lys Leu His Ser Phe Glu Ser His Lys Asp Glu Ile 
305                 310                 315                 320


Phe Gln Val Gln Trp Ser Pro His Asn Glu Thr Ile Leu Ala Ser Ser 
                325                 330                 335


Gly Thr Asp Arg Arg Leu Asn Val Trp Asp Leu Ser Lys Ile Gly Glu 
            340                 345                 350


Glu Gln Ser Pro Glu Asp Ala Glu Asp Gly Pro Pro Glu Leu Leu Phe 
        355                 360                 365


Ile His Gly Gly His Thr Ala Lys Ile Ser Asp Phe Ser Trp Asn Pro 
    370                 375                 380


Asn Glu Pro Trp Val Ile Cys Ser Val Ser Glu Asp Asn Ile Met Gln 
385                 390                 395                 400


Val Trp Gln Met Ala Glu Asn Ile Tyr Asn Asp Glu Asp Pro Glu Gly 
                405                 410                 415


Ser Val Asp Pro Glu Gly Gln Gly Ser 
            420                 425


<210>  1687
<211>  7063
<212>  DNA
<213>  Homo sapiens

<400>  1687
aggagcgctc ccattggctg atgttggcgc gaaggtgcgc gagtcagccc tcgcgctggg     60

ggcgcaggaa acaatagagg ccgcgcgcac agagcgagct cttgcagcct ccccgcccct    120

cccgcaacgc tcgaccccag gattcccccg gctcgcctgc ccgccatggc cgacaaggaa    180

gcagccttcg acgacgcagt ggaagaacga gtgatcaacg aggaatacaa aatatggaaa    240

aagaacaccc cttttcttta tgatttggtg atgacccatg ctctggagtg gcccagccta    300

actgcccagt ggcttccaga tgtaaccaga ccagaaggga aagatttcag cattcatcga    360

cttgtcctgg ggacacacac atcggatgaa caaaaccatc ttgttatagc cagtgtgcag    420

ctccctaatg atgatgctca gtttgatgcg tcacactacg acagtgagaa aggagaattt    480

ggaggttttg gttcagttag tggaaaaatt gaaatagaaa tcaagatcaa ccatgaagga    540

gaagtaaaca gggcccgtta tatgccccag aacccttgta tcatcgcaac aaagactcct    600

tccagtgatg ttcttgtttt tgactataca aaacatcctt ctaaaccaga tccttctgga    660

gagtgcaacc cagacttgcg tctccgtgga catcagaagg aaggctatgg gctttcttgg    720

aacccaaatc tcagtgggca cttacttagt gcttcagatg accataccat ctgcctgtgg    780

gacatcagtg ccgttccaaa ggagggaaaa gtggtagatg cgaagaccat ctttacaggg    840

catacggcag tagtagaaga tgtttcctgg catctactcc atgagtctct gtttgggtca    900

gttgctgatg atcagaaact tatgatttgg gatactcgtt caaacaatac ttccaaacca    960

agccactcag ttgatgctca cactgctgaa gtgaactgcc tttctttcaa tccttatagt   1020

gagttcattc ttgccacagg atcagctgac aagactgttg ccttgtggga tctgagaaat   1080

ctgaaactta agttgcattc ctttgagtca cataaggatg aaatattcca ggttcagtgg   1140

tcacctcaca atgagactat tttagcttcc agtggtactg atcgcagact gaatgtctgg   1200

gatttaagta aaattggaga ggaacaatcc ccagaagatg cagaagacgg gccaccagag   1260

ttgttgttta ttcatggtgg tcatactgcc aagatatctg atttctcctg gaatcccaat   1320

gaaccttggg tgatttgttc tgtatcagaa gacaatatca tgcaagtgtg gcaaatggag   1380

ttagtccttg accactagtt tgatgccatc tccattttgg gtgacctgtt tcaccagcag   1440

gcctgttact ctccatgact aactgtgtaa gtgcttaaaa tggaataaat tgcttttcta   1500

cataacccca tgctgatggg ttttatttag tataaaacat ccatcaaaca ccagtctctg   1560

gcttctagaa gagtccttca gatgacagtt gttgtccatg gtctttgact atcaagagca   1620

gaattaaatg taatagtccc agagctgtag aaaagaactt tactccttcc cagggaaagt   1680

gaaagacata aaacactgaa tcagaggtgg cacagattag tctttgataa ggtaacgttt   1740

ctttgaagtc tatctgtaga gaactacatg gacttccaag agtgtcaaag gcagtgtggt   1800

agagagaatt taaggcaaga tttaaatttg gaaaaggtgc ttgaaccttt tctcagaggt   1860

tttatttccc cagtatgttt ttcactgggg cctttactta ggttagaaat aataggcttt   1920

gaaggcctct atcaccagat gcaataacca gataaaattc ctgttttttc ccaatcgctt   1980

agttttttgt tgttgttgtt ttttaactga gtagatcatt ctgacccaga actactttca   2040

tgaggtaaga tctttgggaa aatctgaata gcgttaacca ttagattcaa atctcaaatg   2100

gtttcttttc aagtctagtt gttttagagt atagtgagaa ataccttgac acaattttaa   2160

gagtaaacta tatgggtcag catatccttg aacaaaaagt agactttgta aaagtattca   2220

tttaaattct aacactcgtg gcacaaaaga atggaaattg taaacccatg taatggaaat   2280

tggctatctt tttgacccca catgtgcccc tcaaaaatgt ttttggtttg ggtcaacaca   2340

aggcaagata cattctttaa aatactccca gatgtgtcca tacattcatc cttcactcag   2400

tgcatatgtg agggttgttg ctggaagaca ggaggctcat ctttcctttc cttggtgcat   2460

tgagatcagt atcaacagca gatgaaatag aatccagcaa agagttgaca tgttctgcct   2520

ccggccaact ctagaatctt tttaagcagg tcagccagta tttgcaactt ccacaggatg   2580

aattgcttgc caagtttctg gcactcttgt ctggttggaa gagtacatcc aaagggtact   2640

tagtgatcct ttgctaagaa gttttttgct gtttccgggt tacagatttg gccatatatt   2700

tctaaacagc ccctgtaaag ttgaaagaaa aagtttataa cagtgaactt ctgaggttta   2760

gttactgcag gctttgttga gaagagattg ttacagtgtg atttatggat gatcagggat   2820

gactttcccc tagcaaatat ttggatgcct cctgtttgtc aaatagaatg aatggtgatg   2880

gtgatgggag ggatagttaa acgttttctc tgctaggtta acttcttaca ggtataatta   2940

caatgcctga aattctgtag tttcatttct ttggattagt cgttgtcttt tccagattgt   3000

acacaatctg atcaacacaa aggtagttag tagatcatta acctcaattg caaggttata   3060

atttctcaaa cattaagcat attatcagtc atgtggattc aaacacagta taagaaaatc   3120

ctcaaggctg ggtgtgatgg cttatgcctg taatcccagc tacttagcag gctgaggcag   3180

gagtattgtt tgaacccagg aggcagagtt gcagtgagcc aagatcgtgc cactactcca   3240

gcctgggcaa aatagcaaga cccgaccccc catctctact aaaaagaaat ttaaaaaaat   3300

aaaatcctag aaaattagaa aaagcaacaa tagttacttg tgggccaggc gcggtggttc   3360

acgcctgtaa tcccagcact ttgagaggct gaggcacgtg gatcacaagg tcaggagttc   3420

aagaccagcc tggccaagat ggtgaaaccc cgtttctact aaaaatacaa aaactagctg   3480

gccgtggtgg catgctcctg tagtcccagc tactcaggag gctgaggcag gaaaatcact   3540

tgaacccagg aggtggaggt tgcagtgaac tgagaccgtg ccactgcact ccagcctggg   3600

tggcagagcg agactgtctc aaaaaaaaaa gaaagttgtg aatttgatgt aagcttagga   3660

aatgaataaa atttataggc atctgtataa tgtacaactt gacacggact ttcttttatc   3720

cttagtttct ttcacggact ctagaacttt tatcagaata tactggtaaa acattggggg   3780

agggatcctg agtaggtgat tggtcagaaa gatgccttca gttttgtcag tgtctaaaag   3840

ttaagtctgt ttaggccaag catggtggct cacacctgaa atcccagcac tctgggaggc   3900

cgaggcaagt ggatcacaag gtcaggagat gagaccatct tagccaacat ggtgaaaccc   3960

cgtctctact aaaatacaaa aaaattagcc aggcgtggtg gtgcgtgcct ataatcccag   4020

ctacttggga ggctgaggca ggggaatcgc ttgaacccgg gaggcagagg tcacgccact   4080

gcactccagc ctggcaacag agcaagactc cgtctcaaaa aaaaaaaaaa aaaaaaagag   4140

taagtctgtg taacatgaac atctctgctt ccacccaaaa ccacagcctt tgaatattat   4200

ataaggaact taatggatag atatgtttat tatttttgat agcacaactg ctttctctgc   4260

tattataagg aaaactgaga atagcaggtg ggtagggtag gatgaggaaa caagatgccc   4320

aaagcctaga tgccacagaa ttcatggtga taatcagggc atattttgag tcctactaga   4380

aacaaacatt ccaaatgaac tctgaatgcc tgactcaggc gttttggagg tttgggttat   4440

ccccttgtca ttaggcacac aagggttttt tgttgttttt gttttttggg tttttgtttt   4500

gttttgaggc agtctcactc tgttgtacaa gctggagtgc tgtattgtga tcttgactca   4560

ctgcaacctc tgcctcctgg ttcaagcgat tctcctgcct tggcctcctg agtagctggg   4620

attataagtg cctgccacta tgcccggcta atttttgtat ttttagtgga gatggagttt   4680

tgccatgttg gccaggctgg tcttgaactc ctgactccag gtgatccacc ctcctcagcc   4740

tcccaaagtg ctaggattac aggcgtgagc caccccgtcc ggcctgtttt taaggcatta   4800

attagtattg ttaggaaagc agtaacaatg caaacaccac tcttctcttc acaaagatca   4860

ccttgagact gtgtctccat tccacctgcc tgagaagtgg gagcatcagc ctgttccagg   4920

ctcttgggta gtagcatagc cctttaaaaa gagagagcca ttttccatgt gtttttggat   4980

aagcacaatt tgaaaatcat ttcccaaatc ctctttttgt ttttgattct aaggtaaaat   5040

tttccctaag ccctcccacc atcccctcag ccagtattag atgagatttg tatagcagca   5100

gaaactgact tataagtaga gagctcttca gcaagactga gccttagctg ttccatctct   5160

ttgttcttct gttgctggag ttgcacccca tttcttaact gcctctggcg ttcttccatt   5220

tcctccagct gttcctgcat gagatggcca agaacatttc taatgagcca aacaataaaa   5280

actcacattg tccactctta cttataaaac acttttttgt tcattgttta atcttgatag   5340

cagtattgag gctggtattt atatgatagg ttatgaaaca ggttcaaaga agttgtgtct   5400

tggaaaaaaa gtgacaatgc ttttgaaaat gatgacgaaa aaggcatctt gtctgttaac   5460

cacagcttgc tttaatagaa tcctgggagg gtgattggga ctttttagta ttacaacctt   5520

agtgtcattg aggaggattt tggtctagtt agtgggctga gtttcatata cctctccctc   5580

catgtgcagg tttgttaaga taattggtag tttttaataa tataaaatac ttaagttgaa   5640

atacaaaagt gtggcaacaa ttattaaata ttggctagaa ttctaggaga gttacacaac   5700

tagtggaagt ccatgtttag aaaataaatg gcttgtttaa ggaaaagttt ttgtgtccaa   5760

agctccttaa agtcagagag atttctacct ggtacttaac atcatatgga aattgatgct   5820

ttagtgaggg tgttggctat cctattgcta atttcctgca tccttttttc ttctttattt   5880

ttgtatagag acagggtctc gctatgttgc ccaggctggt cttgttcctg ggctcaagca   5940

gtcctcccgc ctcggtctcc caaagtgctg ggattacagg tgtgagccac tgtgcccagc   6000

ttatcctttt ttcattacac aaaaagactg aatttggtta gttctaagtt ggaagataaa   6060

gatggtatgc acaggaggcc cttgggagcc ctcagataac tttctcattc ttccagaatc   6120

aggctgggat gcattctgta aattttccct gcctaggatg tatacctgag gaataaggta   6180

aggaagatgt cagcaagtca gtctctggtt tacctgctag ctggcatgga tccttaagga   6240

agcaggaggg agttgggaag agaggaaggg gtgaagttgg tatcttttaa agcgagagtg   6300

attttacctc agattttgaa gaatactaag gaatccagtt gttggggtac atgctattat   6360

tagaaggatc tagataattt gtcctctgag tcatacttga cattgtacct gtggcacatc   6420

aatccgcact gtttgatact ctggctgaat ctcagctttc accaacattg tcaaaggacc   6480

ttttttagtg cccagccatg cctaagagtg tgtcatctga agagggaagc atctgcatac   6540

tgctgtcctg attgctcagt cctcactacc taccagaccc gttggtaagg tacaaaagta   6600

catgcttgga aaagcagtct gcaccaccag tgataagctg tgacagagtg gaacagcctc   6660

aatgaaatga aggaaggatt gctacagtgg cattaaggat ggtctcttaa tcctgtgtta   6720

accactagat taactttaca atcaactcaa aatccttcaa aggctttcca ctttctttag   6780

tggcattcag accccctcta gtttgacccc tacctccaac ttgaacctct gttactcttc   6840

cgtatgaaca ttttcctcta gccctggact actagtaccg aagtcactag tcacatagga   6900

ctcatttgaa atatgactag tctcaattga gatgtaatgt aagtgtaaaa tacacagcag   6960

atttctaaga cagcacacaa aatgtaaaat atgtcaaaaa tatttgatac tgattacatg   7020

ttgaaatata tgtgttgggt taaataaaat gcattaaagt taa                     7063


<210>  1688
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  1688

Met Ala Asp Lys Glu Ala Ala Phe Asp Asp Ala Val Glu Glu Arg Val 
1               5                   10                  15


Ile Asn Glu Glu Tyr Lys Ile Trp Lys Lys Asn Thr Pro Phe Leu Tyr 
            20                  25                  30


Asp Leu Val Met Thr His Ala Leu Glu Trp Pro Ser Leu Thr Ala Gln 
        35                  40                  45


Trp Leu Pro Asp Val Thr Arg Pro Glu Gly Lys Asp Phe Ser Ile His 
    50                  55                  60


Arg Leu Val Leu Gly Thr His Thr Ser Asp Glu Gln Asn His Leu Val 
65                  70                  75                  80


Ile Ala Ser Val Gln Leu Pro Asn Asp Asp Ala Gln Phe Asp Ala Ser 
                85                  90                  95


His Tyr Asp Ser Glu Lys Gly Glu Phe Gly Gly Phe Gly Ser Val Ser 
            100                 105                 110


Gly Lys Ile Glu Ile Glu Ile Lys Ile Asn His Glu Gly Glu Val Asn 
        115                 120                 125


Arg Ala Arg Tyr Met Pro Gln Asn Pro Cys Ile Ile Ala Thr Lys Thr 
    130                 135                 140


Pro Ser Ser Asp Val Leu Val Phe Asp Tyr Thr Lys His Pro Ser Lys 
145                 150                 155                 160


Pro Asp Pro Ser Gly Glu Cys Asn Pro Asp Leu Arg Leu Arg Gly His 
                165                 170                 175


Gln Lys Glu Gly Tyr Gly Leu Ser Trp Asn Pro Asn Leu Ser Gly His 
            180                 185                 190


Leu Leu Ser Ala Ser Asp Asp His Thr Ile Cys Leu Trp Asp Ile Ser 
        195                 200                 205


Ala Val Pro Lys Glu Gly Lys Val Val Asp Ala Lys Thr Ile Phe Thr 
    210                 215                 220


Gly His Thr Ala Val Val Glu Asp Val Ser Trp His Leu Leu His Glu 
225                 230                 235                 240


Ser Leu Phe Gly Ser Val Ala Asp Asp Gln Lys Leu Met Ile Trp Asp 
                245                 250                 255


Thr Arg Ser Asn Asn Thr Ser Lys Pro Ser His Ser Val Asp Ala His 
            260                 265                 270


Thr Ala Glu Val Asn Cys Leu Ser Phe Asn Pro Tyr Ser Glu Phe Ile 
        275                 280                 285


Leu Ala Thr Gly Ser Ala Asp Lys Thr Val Ala Leu Trp Asp Leu Arg 
    290                 295                 300


Asn Leu Lys Leu Lys Leu His Ser Phe Glu Ser His Lys Asp Glu Ile 
305                 310                 315                 320


Phe Gln Val Gln Trp Ser Pro His Asn Glu Thr Ile Leu Ala Ser Ser 
                325                 330                 335


Gly Thr Asp Arg Arg Leu Asn Val Trp Asp Leu Ser Lys Ile Gly Glu 
            340                 345                 350


Glu Gln Ser Pro Glu Asp Ala Glu Asp Gly Pro Pro Glu Leu Leu Phe 
        355                 360                 365


Ile His Gly Gly His Thr Ala Lys Ile Ser Asp Phe Ser Trp Asn Pro 
    370                 375                 380


Asn Glu Pro Trp Val Ile Cys Ser Val Ser Glu Asp Asn Ile Met Gln 
385                 390                 395                 400


Val Trp Gln Met Glu Leu Val Leu Asp His 
                405                 410


<210>  1689
<211>  7949
<212>  DNA
<213>  Homo sapiens

<400>  1689
aggagcgctc ccattggctg atgttggcgc gaaggtgcgc gagtcagccc tcgcgctggg     60

ggcgcaggaa acaatagagg ccgcgcgcac agagcgagct cttgcagcct ccccgcccct    120

cccgcaacgc tcgaccccag gattcccccg gctcgcctgc ccgccatggc cgacaaggaa    180

gcagccttcg acgacgcagt ggaagaacga gtgatcaacg aggaatacaa aatatggaaa    240

aagaacaccc cttttcttta tgatttggtg atgacccatg ctctggagtg gcccagccta    300

actgcccagt ggcttccaga tgtaaccaga ccagaaggga aagatttcag cattcatcga    360

cttgtcctgg ggacacacac atcggatgaa caaaaccatc ttgttatagc cagtgtgcag    420

ctccctaatg atgatgctca gtttgatgcg tcacactacg acagtgagaa aggagaattt    480

ggaggttttg gttcagttag tggaaaaatt gaaatagaaa tcaagatcaa ccatgaagga    540

gaagtaaaca gggcccgtta tatgccccag aacccttgta tcatcgcaac aaagactcct    600

tccagtgatg ttcttgtttt tgactataca aaacatcctt ctaaaccaga tccttctgga    660

gagtgcaacc cagacttgcg tctccgtgga catcagaagg aaggctatgg gctttcttgg    720

aacccaaatc tcagtgggca cttacttagt gcttcagatg accataccat ctgcctgtgg    780

gacatcagtg ccgttccaaa ggagggaaaa gtggtagatg cgaagaccat ctttacaggg    840

catacggcag tagtagaaga tgtttcctgg catctactcc atgagtctct gtttgggtca    900

gttgctgatg atcagaaact tatgatttgg gatactcgtt caaacaatac ttccaaacca    960

agccactcag ttgatgctca cactgctgaa gtgaactgcc tttctttcaa tccttatagt   1020

gagttcattc ttgccacagg atcagctgac aagactgttg ccttgtggga tctgagaaat   1080

ctgaaactta agttgcattc ctttgagtca cataaggatg aaatattcca ggttcagtgg   1140

tcacctcaca atgagactat tttagcttcc agtggtactg atcgcagact gaatgtctgg   1200

gatttaagta aaattggaga ggaacaatcc ccagaagatg cagaagacgg gccaccagag   1260

ttgttgttta ttcatggtgg tcatactgcc aagatatctg atttctcctg gaatcccaat   1320

gaaccttggg tgatttgttc tgtatcagaa gacaatatca tgcaagtgtg gcaaatggca   1380

gagaacattt ataatgatga agaccctgaa ggaagcgtgg atccagaagg acaagggtcc   1440

tagatatgtc tttacttgtt gtgattttag actccccttt tttcttctca accctgagag   1500

tgatttaaca ctggttttga gacagacttt attcagctat ccctctatat aataggtacc   1560

accgataatg ctattagccc aaaccgtggg tgttttctaa atattaatag gggggcttga   1620

ttcaacaaag ccacagactt aacgttgaaa ttttcttcag gaattttcta gtaacccagg   1680

tctaaagtag ctacagaaag gggaatatta tgtgtgatta tttttcttct tatgctatat   1740

ccccaagttt ttcagactca tttaagtaaa ggctagagtg agtaaggaat agagccaaat   1800

gaggtaggtg tctgagccat gaagtataaa tactgaaaga tgtcactttt attcaggaaa   1860

tagggggaga ttcaagtcat atagattcct actcgaaaat cttgacacct gactttccag   1920

gatgcacatt ttcatacgta gaccagtttc ctcttggttt cttcagttaa gtcaaaacaa   1980

cacgttcctc tttccccata tattcatata tttttgctcg ttagtgtatt tcttgagctg   2040

ttttcatgtt gtttatttcc tgtctgtgaa atggtgtttt tttttttgtt gttggttttt   2100

tttttttttt ttttaacttg ggaccaccaa gttgtaaaga tgtatgtttt tacctgacag   2160

ttataccaca ggtagactgt caagttgaga agagtgaatc aataacttgt atttgtttta   2220

aaaattaaat taatccttga taagagttgc tttttttttt taggagttag tccttgacca   2280

ctagtttgat gccatctcca ttttgggtga cctgtttcac cagcaggcct gttactctcc   2340

atgactaact gtgtaagtgc ttaaaatgga ataaattgct tttctacata accccatgct   2400

gatgggtttt atttagtata aaacatccat caaacaccag tctctggctt ctagaagagt   2460

ccttcagatg acagttgttg tccatggtct ttgactatca agagcagaat taaatgtaat   2520

agtcccagag ctgtagaaaa gaactttact ccttcccagg gaaagtgaaa gacataaaac   2580

actgaatcag aggtggcaca gattagtctt tgataaggta acgtttcttt gaagtctatc   2640

tgtagagaac tacatggact tccaagagtg tcaaaggcag tgtggtagag agaatttaag   2700

gcaagattta aatttggaaa aggtgcttga accttttctc agaggtttta tttccccagt   2760

atgtttttca ctggggcctt tacttaggtt agaaataata ggctttgaag gcctctatca   2820

ccagatgcaa taaccagata aaattcctgt tttttcccaa tcgcttagtt ttttgttgtt   2880

gttgtttttt aactgagtag atcattctga cccagaacta ctttcatgag gtaagatctt   2940

tgggaaaatc tgaatagcgt taaccattag attcaaatct caaatggttt cttttcaagt   3000

ctagttgttt tagagtatag tgagaaatac cttgacacaa ttttaagagt aaactatatg   3060

ggtcagcata tccttgaaca aaaagtagac tttgtaaaag tattcattta aattctaaca   3120

ctcgtggcac aaaagaatgg aaattgtaaa cccatgtaat ggaaattggc tatctttttg   3180

accccacatg tgcccctcaa aaatgttttt ggtttgggtc aacacaaggc aagatacatt   3240

ctttaaaata ctcccagatg tgtccataca ttcatccttc actcagtgca tatgtgaggg   3300

ttgttgctgg aagacaggag gctcatcttt cctttccttg gtgcattgag atcagtatca   3360

acagcagatg aaatagaatc cagcaaagag ttgacatgtt ctgcctccgg ccaactctag   3420

aatcttttta agcaggtcag ccagtatttg caacttccac aggatgaatt gcttgccaag   3480

tttctggcac tcttgtctgg ttggaagagt acatccaaag ggtacttagt gatcctttgc   3540

taagaagttt tttgctgttt ccgggttaca gatttggcca tatatttcta aacagcccct   3600

gtaaagttga aagaaaaagt ttataacagt gaacttctga ggtttagtta ctgcaggctt   3660

tgttgagaag agattgttac agtgtgattt atggatgatc agggatgact ttcccctagc   3720

aaatatttgg atgcctcctg tttgtcaaat agaatgaatg gtgatggtga tgggagggat   3780

agttaaacgt tttctctgct aggttaactt cttacaggta taattacaat gcctgaaatt   3840

ctgtagtttc atttctttgg attagtcgtt gtcttttcca gattgtacac aatctgatca   3900

acacaaaggt agttagtaga tcattaacct caattgcaag gttataattt ctcaaacatt   3960

aagcatatta tcagtcatgt ggattcaaac acagtataag aaaatcctca aggctgggtg   4020

tgatggctta tgcctgtaat cccagctact tagcaggctg aggcaggagt attgtttgaa   4080

cccaggaggc agagttgcag tgagccaaga tcgtgccact actccagcct gggcaaaata   4140

gcaagacccg accccccatc tctactaaaa agaaatttaa aaaaataaaa tcctagaaaa   4200

ttagaaaaag caacaatagt tacttgtggg ccaggcgcgg tggttcacgc ctgtaatccc   4260

agcactttga gaggctgagg cacgtggatc acaaggtcag gagttcaaga ccagcctggc   4320

caagatggtg aaaccccgtt tctactaaaa atacaaaaac tagctggccg tggtggcatg   4380

ctcctgtagt cccagctact caggaggctg aggcaggaaa atcacttgaa cccaggaggt   4440

ggaggttgca gtgaactgag accgtgccac tgcactccag cctgggtggc agagcgagac   4500

tgtctcaaaa aaaaaagaaa gttgtgaatt tgatgtaagc ttaggaaatg aataaaattt   4560

ataggcatct gtataatgta caacttgaca cggactttct tttatcctta gtttctttca   4620

cggactctag aacttttatc agaatatact ggtaaaacat tgggggaggg atcctgagta   4680

ggtgattggt cagaaagatg ccttcagttt tgtcagtgtc taaaagttaa gtctgtttag   4740

gccaagcatg gtggctcaca cctgaaatcc cagcactctg ggaggccgag gcaagtggat   4800

cacaaggtca ggagatgaga ccatcttagc caacatggtg aaaccccgtc tctactaaaa   4860

tacaaaaaaa ttagccaggc gtggtggtgc gtgcctataa tcccagctac ttgggaggct   4920

gaggcagggg aatcgcttga acccgggagg cagaggtcac gccactgcac tccagcctgg   4980

caacagagca agactccgtc tcaaaaaaaa aaaaaaaaaa aaagagtaag tctgtgtaac   5040

atgaacatct ctgcttccac ccaaaaccac agcctttgaa tattatataa ggaacttaat   5100

ggatagatat gtttattatt tttgatagca caactgcttt ctctgctatt ataaggaaaa   5160

ctgagaatag caggtgggta gggtaggatg aggaaacaag atgcccaaag cctagatgcc   5220

acagaattca tggtgataat cagggcatat tttgagtcct actagaaaca aacattccaa   5280

atgaactctg aatgcctgac tcaggcgttt tggaggtttg ggttatcccc ttgtcattag   5340

gcacacaagg gttttttgtt gtttttgttt tttgggtttt tgttttgttt tgaggcagtc   5400

tcactctgtt gtacaagctg gagtgctgta ttgtgatctt gactcactgc aacctctgcc   5460

tcctggttca agcgattctc ctgccttggc ctcctgagta gctgggatta taagtgcctg   5520

ccactatgcc cggctaattt ttgtattttt agtggagatg gagttttgcc atgttggcca   5580

ggctggtctt gaactcctga ctccaggtga tccaccctcc tcagcctccc aaagtgctag   5640

gattacaggc gtgagccacc ccgtccggcc tgtttttaag gcattaatta gtattgttag   5700

gaaagcagta acaatgcaaa caccactctt ctcttcacaa agatcacctt gagactgtgt   5760

ctccattcca cctgcctgag aagtgggagc atcagcctgt tccaggctct tgggtagtag   5820

catagccctt taaaaagaga gagccatttt ccatgtgttt ttggataagc acaatttgaa   5880

aatcatttcc caaatcctct ttttgttttt gattctaagg taaaattttc cctaagccct   5940

cccaccatcc cctcagccag tattagatga gatttgtata gcagcagaaa ctgacttata   6000

agtagagagc tcttcagcaa gactgagcct tagctgttcc atctctttgt tcttctgttg   6060

ctggagttgc accccatttc ttaactgcct ctggcgttct tccatttcct ccagctgttc   6120

ctgcatgaga tggccaagaa catttctaat gagccaaaca ataaaaactc acattgtcca   6180

ctcttactta taaaacactt ttttgttcat tgtttaatct tgatagcagt attgaggctg   6240

gtatttatat gataggttat gaaacaggtt caaagaagtt gtgtcttgga aaaaaagtga   6300

caatgctttt gaaaatgatg acgaaaaagg catcttgtct gttaaccaca gcttgcttta   6360

atagaatcct gggagggtga ttgggacttt ttagtattac aaccttagtg tcattgagga   6420

ggattttggt ctagttagtg ggctgagttt catatacctc tccctccatg tgcaggtttg   6480

ttaagataat tggtagtttt taataatata aaatacttaa gttgaaatac aaaagtgtgg   6540

caacaattat taaatattgg ctagaattct aggagagtta cacaactagt ggaagtccat   6600

gtttagaaaa taaatggctt gtttaaggaa aagtttttgt gtccaaagct ccttaaagtc   6660

agagagattt ctacctggta cttaacatca tatggaaatt gatgctttag tgagggtgtt   6720

ggctatccta ttgctaattt cctgcatcct tttttcttct ttatttttgt atagagacag   6780

ggtctcgcta tgttgcccag gctggtcttg ttcctgggct caagcagtcc tcccgcctcg   6840

gtctcccaaa gtgctgggat tacaggtgtg agccactgtg cccagcttat ccttttttca   6900

ttacacaaaa agactgaatt tggttagttc taagttggaa gataaagatg gtatgcacag   6960

gaggcccttg ggagccctca gataactttc tcattcttcc agaatcaggc tgggatgcat   7020

tctgtaaatt ttccctgcct aggatgtata cctgaggaat aaggtaagga agatgtcagc   7080

aagtcagtct ctggtttacc tgctagctgg catggatcct taaggaagca ggagggagtt   7140

gggaagagag gaaggggtga agttggtatc ttttaaagcg agagtgattt tacctcagat   7200

tttgaagaat actaaggaat ccagttgttg gggtacatgc tattattaga aggatctaga   7260

taatttgtcc tctgagtcat acttgacatt gtacctgtgg cacatcaatc cgcactgttt   7320

gatactctgg ctgaatctca gctttcacca acattgtcaa aggacctttt ttagtgccca   7380

gccatgccta agagtgtgtc atctgaagag ggaagcatct gcatactgct gtcctgattg   7440

ctcagtcctc actacctacc agacccgttg gtaaggtaca aaagtacatg cttggaaaag   7500

cagtctgcac caccagtgat aagctgtgac agagtggaac agcctcaatg aaatgaagga   7560

aggattgcta cagtggcatt aaggatggtc tcttaatcct gtgttaacca ctagattaac   7620

tttacaatca actcaaaatc cttcaaaggc tttccacttt ctttagtggc attcagaccc   7680

cctctagttt gacccctacc tccaacttga acctctgtta ctcttccgta tgaacatttt   7740

cctctagccc tggactacta gtaccgaagt cactagtcac ataggactca tttgaaatat   7800

gactagtctc aattgagatg taatgtaagt gtaaaataca cagcagattt ctaagacagc   7860

acacaaaatg taaaatatgt caaaaatatt tgatactgat tacatgttga aatatatgtg   7920

ttgggttaaa taaaatgcat taaagttaa                                     7949


<210>  1690
<211>  425
<212>  PRT
<213>  Homo sapiens

<400>  1690

Met Ala Asp Lys Glu Ala Ala Phe Asp Asp Ala Val Glu Glu Arg Val 
1               5                   10                  15


Ile Asn Glu Glu Tyr Lys Ile Trp Lys Lys Asn Thr Pro Phe Leu Tyr 
            20                  25                  30


Asp Leu Val Met Thr His Ala Leu Glu Trp Pro Ser Leu Thr Ala Gln 
        35                  40                  45


Trp Leu Pro Asp Val Thr Arg Pro Glu Gly Lys Asp Phe Ser Ile His 
    50                  55                  60


Arg Leu Val Leu Gly Thr His Thr Ser Asp Glu Gln Asn His Leu Val 
65                  70                  75                  80


Ile Ala Ser Val Gln Leu Pro Asn Asp Asp Ala Gln Phe Asp Ala Ser 
                85                  90                  95


His Tyr Asp Ser Glu Lys Gly Glu Phe Gly Gly Phe Gly Ser Val Ser 
            100                 105                 110


Gly Lys Ile Glu Ile Glu Ile Lys Ile Asn His Glu Gly Glu Val Asn 
        115                 120                 125


Arg Ala Arg Tyr Met Pro Gln Asn Pro Cys Ile Ile Ala Thr Lys Thr 
    130                 135                 140


Pro Ser Ser Asp Val Leu Val Phe Asp Tyr Thr Lys His Pro Ser Lys 
145                 150                 155                 160


Pro Asp Pro Ser Gly Glu Cys Asn Pro Asp Leu Arg Leu Arg Gly His 
                165                 170                 175


Gln Lys Glu Gly Tyr Gly Leu Ser Trp Asn Pro Asn Leu Ser Gly His 
            180                 185                 190


Leu Leu Ser Ala Ser Asp Asp His Thr Ile Cys Leu Trp Asp Ile Ser 
        195                 200                 205


Ala Val Pro Lys Glu Gly Lys Val Val Asp Ala Lys Thr Ile Phe Thr 
    210                 215                 220


Gly His Thr Ala Val Val Glu Asp Val Ser Trp His Leu Leu His Glu 
225                 230                 235                 240


Ser Leu Phe Gly Ser Val Ala Asp Asp Gln Lys Leu Met Ile Trp Asp 
                245                 250                 255


Thr Arg Ser Asn Asn Thr Ser Lys Pro Ser His Ser Val Asp Ala His 
            260                 265                 270


Thr Ala Glu Val Asn Cys Leu Ser Phe Asn Pro Tyr Ser Glu Phe Ile 
        275                 280                 285


Leu Ala Thr Gly Ser Ala Asp Lys Thr Val Ala Leu Trp Asp Leu Arg 
    290                 295                 300


Asn Leu Lys Leu Lys Leu His Ser Phe Glu Ser His Lys Asp Glu Ile 
305                 310                 315                 320


Phe Gln Val Gln Trp Ser Pro His Asn Glu Thr Ile Leu Ala Ser Ser 
                325                 330                 335


Gly Thr Asp Arg Arg Leu Asn Val Trp Asp Leu Ser Lys Ile Gly Glu 
            340                 345                 350


Glu Gln Ser Pro Glu Asp Ala Glu Asp Gly Pro Pro Glu Leu Leu Phe 
        355                 360                 365


Ile His Gly Gly His Thr Ala Lys Ile Ser Asp Phe Ser Trp Asn Pro 
    370                 375                 380


Asn Glu Pro Trp Val Ile Cys Ser Val Ser Glu Asp Asn Ile Met Gln 
385                 390                 395                 400


Val Trp Gln Met Ala Glu Asn Ile Tyr Asn Asp Glu Asp Pro Glu Gly 
                405                 410                 415


Ser Val Asp Pro Glu Gly Gln Gly Ser 
            420                 425


<210>  1691
<211>  816
<212>  DNA
<213>  Homo sapiens

<400>  1691
gctcccattg gctgatgttg gcgcgaaggt gcgcgagtca gccctcgcgc tgggggcgca     60

ggaaacaata gaggccgcgc gcacagagcg agctcttgca gcctccccgc ccctcccgca    120

acgctcgacc ccaggattcc cccggctcgc ctgcccgcca tggccgacaa ggaagcagcc    180

ttcgacgacg cagtggaaga acgagtgatc aacgaggaat acaaaatatg gaaaaagaac    240

accccttttc tttatgattt ggtgatgacc catgctctgg agtggcccag cctaactgcc    300

cagtggcttc cagatgtaac cagaccagaa gggaaagatt tcagcattca tcgacttgtc    360

ctggggacac acacatcgga tgaacaaaac catcttgtta tagccagtgt gcagctccct    420

aatgatgatg ctcagtttga tgcgtcacac tacgacagtg agaaaggaga atttggaggt    480

tttggttcag ttagtggaaa aattgaaata gaaatcaaga tcaaccatga aggagaagta    540

aacagggccc gttatatgcc ccagaaccct tgtatcatcg caacaaagac tccttccagt    600

gatgttcttg tttttgacta tacaaaacat ccttctaaac caggtatgtg cccttttcta    660

ttcaaataca aatgagtcac tatagaaata catggttcca ctcactgtga gtttaattgc    720

atgttactct gtgtaattta acatcttgtg atttgtattg atatgtgtat atttttcttc    780

attttgcctc catgaaaaaa taatgctttt ttacat                              816


<210>  1692
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  1692

Met Ala Asp Lys Glu Ala Ala Phe Asp Asp Ala Val Glu Glu Arg Val 
1               5                   10                  15


Ile Asn Glu Glu Tyr Lys Ile Trp Lys Lys Asn Thr Pro Phe Leu Tyr 
            20                  25                  30


Asp Leu Val Met Thr His Ala Leu Glu Trp Pro Ser Leu Thr Ala Gln 
        35                  40                  45


Trp Leu Pro Asp Val Thr Arg Pro Glu Gly Lys Asp Phe Ser Ile His 
    50                  55                  60


Arg Leu Val Leu Gly Thr His Thr Ser Asp Glu Gln Asn His Leu Val 
65                  70                  75                  80


Ile Ala Ser Val Gln Leu Pro Asn Asp Asp Ala Gln Phe Asp Ala Ser 
                85                  90                  95


His Tyr Asp Ser Glu Lys Gly Glu Phe Gly Gly Phe Gly Ser Val Ser 
            100                 105                 110


Gly Lys Ile Glu Ile Glu Ile Lys Ile Asn His Glu Gly Glu Val Asn 
        115                 120                 125


Arg Ala Arg Tyr Met Pro Gln Asn Pro Cys Ile Ile Ala Thr Lys Thr 
    130                 135                 140


Pro Ser Ser Asp Val Leu Val Phe Asp Tyr Thr Lys His Pro Ser Lys 
145                 150                 155                 160


Pro Gly Met Cys Pro Phe Leu Phe Lys Tyr Lys 
                165                 170


<210>  1693
<211>  691
<212>  DNA
<213>  Homo sapiens

<400>  1693
gcgcacagag cgagctcttg cagcctcccc gcccctcccg caacgctcga ccccaggatt     60

cccccggctc gcctgcccgc catggccgac aaggaagcag ccttcgacga cgcagtggaa    120

gaacgagtga tcaacgagga atacaaaata tggaaaaaga acaccccttt tctttatgat    180

ttggtgatga cccatgctct ggagtggccc agcctaactg cccagtggct tccagatgta    240

accaggtgac atgactctcc cgaacgttat tttgatgtat tttcagtgta gatttctcat    300

attgattttc ttttttccgc tcttcagtca cccggagaag gcatgtgatc aaaacctctt    360

ggtgacattt tttctaggcc acaaagtaag gcaaaataac aaaatgattt tgtaacttac    420

ctgacaagag aaaacatatt ggcgtttttt tctcaatact gaattaaata gctgtagctg    480

atgataatac ctgtaataat agtggctgta ccaaataata gtacaaaact tgtcaacttt    540

caaaaagtat tatggccagg agcagtggct cacacttgga atccgagcac tttgggaggc    600

ccaggcagga gacttacttg aggccaggag ttggagacca gccctgggaa taccctcgtc    660

tctactgccc cccacacaaa aaaagaaaaa a                                   691


<210>  1694
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  1694

Met Ala Asp Lys Glu Ala Ala Phe Asp Asp Ala Val Glu Glu Arg Val 
1               5                   10                  15


Ile Asn Glu Glu Tyr Lys Ile Trp Lys Lys Asn Thr Pro Phe Leu Tyr 
            20                  25                  30


Asp Leu Val Met Thr His Ala Leu Glu Trp Pro Ser Leu Thr Ala Gln 
        35                  40                  45


Trp Leu Pro Asp Val Thr Arg 
    50                  55


<210>  1695
<211>  288
<212>  DNA
<213>  Homo sapiens

<400>  1695
atttggaata atggattttc tggtacaaaa gtaagttttc tgaattacat tcaaaagcga     60

ttgtatgcta agtaaattcc ttcaaaactt ggatctttaa aagttaagat aattgcaaaa    120

tgttattaga ctatgatgta gctcaacaaa tgaacttgtg gcagagtact taatgagaag    180

tgtactggaa tggtgattcc acatttacta tagtcatatg ctaaattgtg cttattggac    240

tagtggatca caaatattgg ccatcccata cctactaaac attctaga                 288


<210>  1696
<211>  3592
<212>  DNA
<213>  Homo sapiens

<400>  1696
ggagaaatct aaccctgagg agagcctcag agccgagcag agccccagca tggaggagaa     60

cctgagcata gaggacctgg aattgctaga ggggcgtttc cagcagtgtg tccaagctgt    120

ggcccagctg gaagaggaga gggatcagct catccatgag cttgtattgc tccgggaacc    180

agccctgcag gaggtacagc aagtccatca agacatcctg gctgcctaca agctccatgc    240

ccaagcagag ctggagagag atggcctaag ggaggagatc cggctggtca agcagaagct    300

tttcaaagtg acaaaggaat gtgtggccta ccaataccag ctggagtgcc gccagcagga    360

cgtggctcag tttgccgatt tccgggaagt gctgactaca agggcaaccc agctctcaga    420

ggaactggcc cagctccggg atgcctatca gaagcagaag gagcagctgc ggcaacaact    480

agaagcccct ccaagccaga gggatgggca ctttctccag gaaagccggc gactctctgc    540

ccagtttgaa aatctcatgg cagagagccg ccaggacctg gaggaggagt atgagcctca    600

gttcctgcgg ctcctagaga ggaaagaagc tgggaccaaa gctctgcaga gaacccaggc    660

tgagatccag gaaatgaagg aggctctgag acccctgcaa gcagaggccc ggcagctccg    720

cctgcaaaac aggaacctgg aggaccagat cgcacttgtg aggcaaaaac gagatgaaga    780

ggtgcagcag tacagggaac agctggagga aatggaagaa cgccagaggc agttaagaaa    840

tggggtgcaa ctccagcaac agaagaacaa agagatggaa cagctaaggc tcagtcttgc    900

tgaagagctc tctacttata aggctatgct actacccaag agcctggaac aggctgatgc    960

tcccacttct caggcaggtg gaatggagac acagtctcaa ggggctgttt agaaatatat   1020

ggccaaatct gtaacccgga aacagcaaaa aacttcttag caaaggatca ctaagtaccc   1080

tttggatgta ctcttccaac cagacaagag tgccagaaac ttggcaagca attcatcctg   1140

tggaagttgc aaatactggc tgacctgctt aaaaagattc tagagttggc cggaggcaga   1200

acatgtcaac tctttgctgg attctatttc atctgctgtt gatactgatc tcaatgcacc   1260

aaggaaagga aagatgagcc tcctgtcttc cagcaacaac cctcacatat gcactgagtg   1320

aaggatgaat gtatggacac atctgggagt attttaaaga atgtatcttg ccttgtgttg   1380

acccaaacca aaaacatttt tgaggggcac atgtggggtc aaaaagatag ccaatttcca   1440

ttacatgggt ttacaatttc cattcttttg tgccacgagt gttagaattt aaatgaatac   1500

ttttacaaag tctacttttt gttcaaggat atgctgaccc atatagttta ctcttaaaat   1560

tgtgtcaagg tatttctcac tatactctaa aacaactaga cttgaaaaga aaccatttga   1620

gatttgaatc taatggttaa cgctattcag attttcccaa agatcttacc tcatgaaagt   1680

agttctgggt cagaatgatc tactcagtta aaaaacaaca acaacaaaaa actaagcgat   1740

tgggaaaaaa caggaatttt atctggttat tgcatctggt gatagaggcc ttcaaagcct   1800

attatttcta acctaagtaa aggccccagt gaaaaacata ctggggaaat aaaacctctg   1860

agaaaaggtt caagcacctt ttccaaattt aaatcttgcc ttaaattctc tctaccacac   1920

tgcctttgac actcttggaa gtccatgtag ttctctacag atagacttca aagaaacgtt   1980

accttatcaa agactaatct gtgccacctc tgattcagtg ttttatgtct ttcactttcc   2040

ctgggaagga gtaaagttct tttctacagc tctgggacta ttacatttaa ttctgctctt   2100

gatagtcaaa gaccatggac aacaactgtc atctgaagga ctcttctaga agccagagac   2160

tggtgtttga tggatgtttt atactaaata aaacccatca gcatggggtt atgtagaaaa   2220

gcaatttatt ccattttaag cacttacaca gttagtcatg gagagtaaca ggcctgctgg   2280

tgaaacaggt cacccaaaat ggagatggca tcaaactagt ggtcaaggac taactcctaa   2340

aaaaaaaaag caactcttat caaggattaa tttaattttt aaaacaaata caagttattg   2400

attcactctt ctcaacttga cagtctacct gtggtataac tgtcaggtaa aaacatacat   2460

ctttacaact tggtggtccc aagttaaaaa aaaaaaaaaa aaaaccaaca acaaaaaaaa   2520

aaacaccatt tcacagacag gaaataaaca acatgaaaac agctcaagaa atacactaac   2580

gagcaaaaat atatgaatat atggggaaag aggaacgtgt tgttttgact taactgaaga   2640

aaccaagagg aaactggtct acgtatgaaa atgtgcatcc tggaaagtca ggtgtcaaga   2700

ttttcgagta ggaatctata tgacttgaat ctccccctat ttcctgaata aaagtgacat   2760

ctttcagtat ttatacttca tggctcagac acctacctca tttggctcta ttccttactc   2820

actctagcct ttacttaaat gagtctgaaa aacttgggga tatagcataa gaagaaaaat   2880

aatcacacat aatattcccc tttctgtagc tactttagac ctgggttact agaaaattcc   2940

tgaagaaaat ttcaacgtta agtctgtggc tttgttgaat caagcccccc tattaatatt   3000

tagaaaacac ccacggtttg ggctaatagc attatcggtg gtacctatta tatagaggga   3060

tagctgaata aagtctgtct caaaaccagt gttaaatcac tctcagggtt gagaagaaaa   3120

aaggggagtc taaaatcaca acaagtaaag acatatctag gacccttgtc cttctggatc   3180

cacgcttcct tcagggtctt catcattata aatgttctct gcctgcccaa aaacaagaaa   3240

aagaatttaa acatgaagac ttcttctaaa actcaaggtt tcaacaacag attaggccag   3300

gaagccagag agtaaatact ttatagcttt tgggccacac aatctgtgtt acaactattc   3360

aactcttgga tgaaagtatc cggagacaac ctataatggg taatgaaata ttaattagca   3420

tgatcatgtt ccaataaaaa taagcagctg atccccagac gcctgattag gacattccca   3480

caaaactgca gtgtggatac tatttgtctt gatagccaac attcttgagt tctttaacca   3540

ggcattatta tttttctttc cttttgagat ggagccttgc tctgtctccc ag           3592


<210>  1697
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  1697

Met Glu Glu Asn Leu Ser Ile Glu Asp Leu Glu Leu Leu Glu Gly Arg 
1               5                   10                  15


Phe Gln Gln Cys Val Gln Ala Val Ala Gln Leu Glu Glu Glu Arg Asp 
            20                  25                  30


Gln Leu Ile His Glu Leu Val Leu Leu Arg Glu Pro Ala Leu Gln Glu 
        35                  40                  45


Val Gln Gln Val His Gln Asp Ile Leu Ala Ala Tyr Lys Leu His Ala 
    50                  55                  60


Gln Ala Glu Leu Glu Arg Asp Gly Leu Arg Glu Glu Ile Arg Leu Val 
65                  70                  75                  80


Lys Gln Lys Leu Phe Lys Val Thr Lys Glu Cys Val Ala Tyr Gln Tyr 
                85                  90                  95


Gln Leu Glu Cys Arg Gln Gln Asp Val Ala Gln Phe Ala Asp Phe Arg 
            100                 105                 110


Glu Val Leu Thr Thr Arg Ala Thr Gln Leu Ser Glu Glu Leu Ala Gln 
        115                 120                 125


Leu Arg Asp Ala Tyr Gln Lys Gln Lys Glu Gln Leu Arg Gln Gln Leu 
    130                 135                 140


Glu Ala Pro Pro Ser Gln Arg Asp Gly His Phe Leu Gln Glu Ser Arg 
145                 150                 155                 160


Arg Leu Ser Ala Gln Phe Glu Asn Leu Met Ala Glu Ser Arg Gln Asp 
                165                 170                 175


Leu Glu Glu Glu Tyr Glu Pro Gln Phe Leu Arg Leu Leu Glu Arg Lys 
            180                 185                 190


Glu Ala Gly Thr Lys Ala Leu Gln Arg Thr Gln Ala Glu Ile Gln Glu 
        195                 200                 205


Met Lys Glu Ala Leu Arg Pro Leu Gln Ala Glu Ala Arg Gln Leu Arg 
    210                 215                 220


Leu Gln Asn Arg Asn Leu Glu Asp Gln Ile Ala Leu Val Arg Gln Lys 
225                 230                 235                 240


Arg Asp Glu Glu Val Gln Gln Tyr Arg Glu Gln Leu Glu Glu Met Glu 
                245                 250                 255


Glu Arg Gln Arg Gln Leu Arg Asn Gly Val Gln Leu Gln Gln Gln Lys 
            260                 265                 270


Asn Lys Glu Met Glu Gln Leu Arg Leu Ser Leu Ala Glu Glu Leu Ser 
        275                 280                 285


Thr Tyr Lys Ala Met Leu Leu Pro Lys Ser Leu Glu Gln Ala Asp Ala 
    290                 295                 300


Pro Thr Ser Gln Ala Gly Gly Met Glu Thr Gln Ser Gln Gly Ala Val 
305                 310                 315                 320


<210>  1698
<211>  3512
<212>  DNA
<213>  Homo sapiens

<400>  1698
ggagaaatct aaccctgagg agagcctcag agccgagcag agccccagca tggaggagaa     60

cctgagcata gaggacctgg aattgctaga ggggcgtttc cagcagtgtg tccaagctgt    120

ggcccagctg gaagaggaga gggatcagct catccatgag cttgtattgc tccgggaacc    180

agccctgcag gaggtacagc aagtccatca agacatcctg gctgcctaca agctccatgc    240

ccaagcagag ctggagagag atggcctaag ggaggagatc cggctggtca agcagaagct    300

tttcaaagtg acaaaggaat gtgtggccta ccaataccag ctggagtgcc gccagcagga    360

cgtggctcag tttgccgatt tccgggaagt gctgactaca agggcaaccc agctctcaga    420

ggaactggcc cagctccggg atgcctatca gaagcagaag gagcagctgc ggcaacaact    480

agaagcccct ccaagccaga gggatgggca ctttctccag gaaagccggc gactctctgc    540

ccagtttgaa aatctcatgg cagagagccg ccaggacctg gaggaggagt atgagcctca    600

gttcctgcgg ctcctagaga ggaaagaagc tgggaccaaa gctctgcaga gaacccaggc    660

tgagatccag gaaatgaagg aggctctgag acccctgcaa gcagaggccc ggcagctccg    720

cctgcaaaac aggaacctgg aggaccagat cgcacttgtg aggcaaaaac gagatgaaga    780

ggtgcagcag tacagggaac agctggagga aatggaagaa cgccagaggc agttaagaaa    840

tggggtgcaa ctccagcaac agaagaacaa agagatggaa cagctaaggc tcagtcttgc    900

tgaagagctc tctacttata agggctgttt agaaatatat ggccaaatct gtaacccgga    960

aacagcaaaa aacttcttag caaaggatca ctaagtaccc tttggatgta ctcttccaac   1020

cagacaagag tgccagaaac ttggcaagca attcatcctg tggaagttgc aaatactggc   1080

tgacctgctt aaaaagattc tagagttggc cggaggcaga acatgtcaac tctttgctgg   1140

attctatttc atctgctgtt gatactgatc tcaatgcacc aaggaaagga aagatgagcc   1200

tcctgtcttc cagcaacaac cctcacatat gcactgagtg aaggatgaat gtatggacac   1260

atctgggagt attttaaaga atgtatcttg ccttgtgttg acccaaacca aaaacatttt   1320

tgaggggcac atgtggggtc aaaaagatag ccaatttcca ttacatgggt ttacaatttc   1380

cattcttttg tgccacgagt gttagaattt aaatgaatac ttttacaaag tctacttttt   1440

gttcaaggat atgctgaccc atatagttta ctcttaaaat tgtgtcaagg tatttctcac   1500

tatactctaa aacaactaga cttgaaaaga aaccatttga gatttgaatc taatggttaa   1560

cgctattcag attttcccaa agatcttacc tcatgaaagt agttctgggt cagaatgatc   1620

tactcagtta aaaaacaaca acaacaaaaa actaagcgat tgggaaaaaa caggaatttt   1680

atctggttat tgcatctggt gatagaggcc ttcaaagcct attatttcta acctaagtaa   1740

aggccccagt gaaaaacata ctggggaaat aaaacctctg agaaaaggtt caagcacctt   1800

ttccaaattt aaatcttgcc ttaaattctc tctaccacac tgcctttgac actcttggaa   1860

gtccatgtag ttctctacag atagacttca aagaaacgtt accttatcaa agactaatct   1920

gtgccacctc tgattcagtg ttttatgtct ttcactttcc ctgggaagga gtaaagttct   1980

tttctacagc tctgggacta ttacatttaa ttctgctctt gatagtcaaa gaccatggac   2040

aacaactgtc atctgaagga ctcttctaga agccagagac tggtgtttga tggatgtttt   2100

atactaaata aaacccatca gcatggggtt atgtagaaaa gcaatttatt ccattttaag   2160

cacttacaca gttagtcatg gagagtaaca ggcctgctgg tgaaacaggt cacccaaaat   2220

ggagatggca tcaaactagt ggtcaaggac taactcctaa aaaaaaaaag caactcttat   2280

caaggattaa tttaattttt aaaacaaata caagttattg attcactctt ctcaacttga   2340

cagtctacct gtggtataac tgtcaggtaa aaacatacat ctttacaact tggtggtccc   2400

aagttaaaaa aaaaaaaaaa aaaaccaaca acaaaaaaaa aaacaccatt tcacagacag   2460

gaaataaaca acatgaaaac agctcaagaa atacactaac gagcaaaaat atatgaatat   2520

atggggaaag aggaacgtgt tgttttgact taactgaaga aaccaagagg aaactggtct   2580

acgtatgaaa atgtgcatcc tggaaagtca ggtgtcaaga ttttcgagta ggaatctata   2640

tgacttgaat ctccccctat ttcctgaata aaagtgacat ctttcagtat ttatacttca   2700

tggctcagac acctacctca tttggctcta ttccttactc actctagcct ttacttaaat   2760

gagtctgaaa aacttgggga tatagcataa gaagaaaaat aatcacacat aatattcccc   2820

tttctgtagc tactttagac ctgggttact agaaaattcc tgaagaaaat ttcaacgtta   2880

agtctgtggc tttgttgaat caagcccccc tattaatatt tagaaaacac ccacggtttg   2940

ggctaatagc attatcggtg gtacctatta tatagaggga tagctgaata aagtctgtct   3000

caaaaccagt gttaaatcac tctcagggtt gagaagaaaa aaggggagtc taaaatcaca   3060

acaagtaaag acatatctag gacccttgtc cttctggatc cacgcttcct tcagggtctt   3120

catcattata aatgttctct gcctgcccaa aaacaagaaa aagaatttaa acatgaagac   3180

ttcttctaaa actcaaggtt tcaacaacag attaggccag gaagccagag agtaaatact   3240

ttatagcttt tgggccacac aatctgtgtt acaactattc aactcttgga tgaaagtatc   3300

cggagacaac ctataatggg taatgaaata ttaattagca tgatcatgtt ccaataaaaa   3360

taagcagctg atccccagac gcctgattag gacattccca caaaactgca gtgtggatac   3420

tatttgtctt gatagccaac attcttgagt tctttaacca ggcattatta tttttctttc   3480

cttttgagat ggagccttgc tctgtctccc ag                                 3512


<210>  1699
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  1699

Met Glu Glu Asn Leu Ser Ile Glu Asp Leu Glu Leu Leu Glu Gly Arg 
1               5                   10                  15


Phe Gln Gln Cys Val Gln Ala Val Ala Gln Leu Glu Glu Glu Arg Asp 
            20                  25                  30


Gln Leu Ile His Glu Leu Val Leu Leu Arg Glu Pro Ala Leu Gln Glu 
        35                  40                  45


Val Gln Gln Val His Gln Asp Ile Leu Ala Ala Tyr Lys Leu His Ala 
    50                  55                  60


Gln Ala Glu Leu Glu Arg Asp Gly Leu Arg Glu Glu Ile Arg Leu Val 
65                  70                  75                  80


Lys Gln Lys Leu Phe Lys Val Thr Lys Glu Cys Val Ala Tyr Gln Tyr 
                85                  90                  95


Gln Leu Glu Cys Arg Gln Gln Asp Val Ala Gln Phe Ala Asp Phe Arg 
            100                 105                 110


Glu Val Leu Thr Thr Arg Ala Thr Gln Leu Ser Glu Glu Leu Ala Gln 
        115                 120                 125


Leu Arg Asp Ala Tyr Gln Lys Gln Lys Glu Gln Leu Arg Gln Gln Leu 
    130                 135                 140


Glu Ala Pro Pro Ser Gln Arg Asp Gly His Phe Leu Gln Glu Ser Arg 
145                 150                 155                 160


Arg Leu Ser Ala Gln Phe Glu Asn Leu Met Ala Glu Ser Arg Gln Asp 
                165                 170                 175


Leu Glu Glu Glu Tyr Glu Pro Gln Phe Leu Arg Leu Leu Glu Arg Lys 
            180                 185                 190


Glu Ala Gly Thr Lys Ala Leu Gln Arg Thr Gln Ala Glu Ile Gln Glu 
        195                 200                 205


Met Lys Glu Ala Leu Arg Pro Leu Gln Ala Glu Ala Arg Gln Leu Arg 
    210                 215                 220


Leu Gln Asn Arg Asn Leu Glu Asp Gln Ile Ala Leu Val Arg Gln Lys 
225                 230                 235                 240


Arg Asp Glu Glu Val Gln Gln Tyr Arg Glu Gln Leu Glu Glu Met Glu 
                245                 250                 255


Glu Arg Gln Arg Gln Leu Arg Asn Gly Val Gln Leu Gln Gln Gln Lys 
            260                 265                 270


Asn Lys Glu Met Glu Gln Leu Arg Leu Ser Leu Ala Glu Glu Leu Ser 
        275                 280                 285


Thr Tyr Lys Gly Cys Leu Glu Ile Tyr Gly Gln Ile Cys Asn Pro Glu 
    290                 295                 300


Thr Ala Lys Asn Phe Leu Ala Lys Asp His 
305                 310


<210>  1700
<211>  6584
<212>  DNA
<213>  Homo sapiens

<400>  1700
ggttgtctcc ggatactttc atccaagagt tgaatagttg taacacagat tgtgtggccc     60

aaaagctata aagtatttac tctctggctt cctggcctaa tctgttgttg aaaccttgag    120

ttttagaaga agtcttcatg tttaaattct ttttcttgtt tttgggcagg cagagaacat    180

ttataatgat gaagaccctg aaggaagcgt ggatccagaa ggacaagggt cctagatatg    240

tctttacttg ttgtgatttt agactcccct tttttcttct caaccctgag agtgatttaa    300

cactggtttt gagacagact ttattcagct atccctctat ataataggta ccaccgataa    360

tgctattagc ccaaaccgtg ggtgttttct aaatattaat aggggggctt gattcaacaa    420

agccacagac ttaacgttga aattttcttc aggaattttc tagtaaccca ggtctaaagt    480

agctacagaa aggggaatat tatgtgtgat tatttttctt cttatgctat atccccaagt    540

ttttcagact catttaagta aaggctagag tgagtaagga atagagccaa atgaggtagg    600

tgtctgagcc atgaagtata aatactgaaa gatgtcactt ttattcagga aataggggga    660

gattcaagtc atatagattc ctactcgaaa atcttgacac ctgactttcc aggatgcaca    720

ttttcatacg tagaccagtt tcctcttggt ttcttcagtt aagtcaaaac aacacgttcc    780

tctttcccca tatattcata tatttttgct cgttagtgta tttcttgagc tgttttcatg    840

ttgtttattt cctgtctgtg aaatgtaatc cttgataaga gttgcttttt ttttttagga    900

gttagtcctt gaccactagt ttgatgccat ctccattttg ggtgacctgt ttcaccagca    960

ggcctgttac tctccatgac taactgtgta agtgcttaaa atggaataaa ttgcttttct   1020

acataacccc atgctgatgg gttttattta gtataaaaca tccatcaaac accagtctct   1080

ggcttctaga agagtccttc agatgacagt tgttgtccat ggtctttgac tatcaagagc   1140

agaattaaat gtaatagtcc cagagctgta gaaaagaact ttactccttc ccagggaaag   1200

tgaaagacat aaaacactga atcagaggtg gcacagatta gtctttgata aggtaacgtt   1260

tctttgaagt ctatctgtag agaactacat ggacttccaa gagtgtcaaa ggcagtgtgg   1320

tagagagaat ttaaggcaag atttaaattt ggaaaaggtg cttgaacctt ttctcagagg   1380

ttttatttcc ccagtatgtt tttcactggg gcctttactt aggttagaaa taataggctt   1440

tgaaggcctc tatcaccaga tgcaataacc agataaaatt cctgtttttt cccaatcgct   1500

tagttttttg ttgttgttgt tttttaactg agtagatcat tctgacccag aactactttc   1560

atgaggtaag atctttggga aaatctgaat agcgttaacc attagattca aatctcaaat   1620

ggtttctttt caagtctagt tgttttagag tatagtgaga aataccttga cacaatttta   1680

agagtaaact atatgggtca gcatatcctt gaacaaaaag tagactttgt aaaagtattc   1740

atttaaattc taacactcgt ggcacaaaag aatggaaatt gtaaacccat gtaatggaaa   1800

ttggctatct ttttgacccc acatgtgccc ctcaaaaatg tttttggttt gggtcaacac   1860

aaggcaagat acattcttta aaatactccc agatgtgtcc atacattcat ccttcactca   1920

gtgcatatgt gagggttgtt gctggaagac aggaggctca tctttccttt ccttggtgca   1980

ttgagatcag tatcaacagc agatgaaata gaatccagca aagagttgac atgttctgcc   2040

tccggccaac tctagaatct ttttaagcag gtcagccagt atttgcaact tccacaggat   2100

gaattgcttg ccaagtttct ggcactcttg tctggttgga agagtacatc caaagggtac   2160

ttagtgatcc tttgctaaga agttttttgc tgtttccggg ttacagattt ggccatatat   2220

ttctaaacag cccctgtaaa gttgaaagaa aaagtttata acagtgaact tctgaggttt   2280

agttactgca ggctttgttg agaagagatt gttacagtgt gatttatgga tgatcaggga   2340

tgactttccc ctagcaaata tttggatgcc tcctgtttgt caaatagaat gaatggtgat   2400

ggtgatggga gggatagtta aacgttttct ctgctaggtt aacttcttac aggtataatt   2460

acaatgcctg aaattctgta gtttcatttc tttggattag tcgttgtctt ttccagattg   2520

tacacaatct gatcaacaca aaggtagtta gtagatcatt aacctcaatt gcaaggttat   2580

aatttctcaa acattaagca tattatcagt catgtggatt caaacacagt ataagaaaat   2640

cctcaaggct gggtgtgatg gcttatgcct gtaatcccag ctacttagca ggctgaggca   2700

ggagtattgt ttgaacccag gaggcagagt tgcagtgagc caagatcgtg ccactactcc   2760

agcctgggca aaatagcaag acccgacccc ccatctctac taaaaagaaa tttaaaaaaa   2820

taaaatccta gaaaattaga aaaagcaaca atagttactt gtgggccagg cgcggtggtt   2880

cacgcctgta atcccagcac tttgagaggc tgaggcacgt ggatcacaag gtcaggagtt   2940

caagaccagc ctggccaaga tggtgaaacc ccgtttctac taaaaataca aaaactagct   3000

ggccgtggtg gcatgctcct gtagtcccag ctactcagga ggctgaggca ggaaaatcac   3060

ttgaacccag gaggtggagg ttgcagtgaa ctgagaccgt gccactgcac tccagcctgg   3120

gtggcagagc gagactgtct caaaaaaaaa agaaagttgt gaatttgatg taagcttagg   3180

aaatgaataa aatttatagg catctgtata atgtacaact tgacacggac tttcttttat   3240

ccttagtttc tttcacggac tctagaactt ttatcagaat atactggtaa aacattgggg   3300

gagggatcct gagtaggtga ttggtcagaa agatgccttc agttttgtca gtgtctaaaa   3360

gttaagtctg tttaggccaa gcatggtggc tcacacctga aatcccagca ctctgggagg   3420

ccgaggcaag tggatcacaa ggtcaggaga tgagaccatc ttagccaaca tggtgaaacc   3480

ccgtctctac taaaatacaa aaaaattagc caggcgtggt ggtgcgtgcc tataatccca   3540

gctacttggg aggctgaggc aggggaatcg cttgaacccg ggaggcagag gtcacgccac   3600

tgcactccag cctggcaaca gagcaagact ccgtctcaaa aaaaaaaaaa aaaaaaaaga   3660

gtaagtctgt gtaacatgaa catctctgct tccacccaaa accacagcct ttgaatatta   3720

tataaggaac ttaatggata gatatgttta ttatttttga tagcacaact gctttctctg   3780

ctattataag gaaaactgag aatagcaggt gggtagggta ggatgaggaa acaagatgcc   3840

caaagcctag atgccacaga attcatggtg ataatcaggg catattttga gtcctactag   3900

aaacaaacat tccaaatgaa ctctgaatgc ctgactcagg cgttttggag gtttgggtta   3960

tccccttgtc attaggcaca caagggtttt ttgttgtttt tgttttttgg gtttttgttt   4020

tgttttgagg cagtctcact ctgttgtaca agctggagtg ctgtattgtg atcttgactc   4080

actgcaacct ctgcctcctg gttcaagcga ttctcctgcc ttggcctcct gagtagctgg   4140

gattataagt gcctgccact atgcccggct aatttttgta tttttagtgg agatggagtt   4200

ttgccatgtt ggccaggctg gtcttgaact cctgactcca ggtgatccac cctcctcagc   4260

ctcccaaagt gctaggatta caggcgtgag ccaccccgtc cggcctgttt ttaaggcatt   4320

aattagtatt gttaggaaag cagtaacaat gcaaacacca ctcttctctt cacaaagatc   4380

accttgagac tgtgtctcca ttccacctgc ctgagaagtg ggagcatcag cctgttccag   4440

gctcttgggt agtagcatag ccctttaaaa agagagagcc attttccatg tgtttttgga   4500

taagcacaat ttgaaaatca tttcccaaat cctctttttg tttttgattc taaggtaaaa   4560

ttttccctaa gccctcccac catcccctca gccagtatta gatgagattt gtatagcagc   4620

agaaactgac ttataagtag agagctcttc agcaagactg agccttagct gttccatctc   4680

tttgttcttc tgttgctgga gttgcacccc atttcttaac tgcctctggc gttcttccat   4740

ttcctccagc tgttcctgca tgagatggcc aagaacattt ctaatgagcc aaacaataaa   4800

aactcacatt gtccactctt acttataaaa cacttttttg ttcattgttt aatcttgata   4860

gcagtattga ggctggtatt tatatgatag gttatgaaac aggttcaaag aagttgtgtc   4920

ttggaaaaaa agtgacaatg cttttgaaaa tgatgacgaa aaaggcatct tgtctgttaa   4980

ccacagcttg ctttaataga atcctgggag ggtgattggg actttttagt attacaacct   5040

tagtgtcatt gaggaggatt ttggtctagt tagtgggctg agtttcatat acctctccct   5100

ccatgtgcag gtttgttaag ataattggta gtttttaata atataaaata cttaagttga   5160

aatacaaaag tgtggcaaca attattaaat attggctaga attctaggag agttacacaa   5220

ctagtggaag tccatgttta gaaaataaat ggcttgttta aggaaaagtt tttgtgtcca   5280

aagctcctta aagtcagaga gatttctacc tggtacttaa catcatatgg aaattgatgc   5340

tttagtgagg gtgttggcta tcctattgct aatttcctgc atcctttttt cttctttatt   5400

tttgtataga gacagggtct cgctatgttg cccaggctgg tcttgttcct gggctcaagc   5460

agtcctcccg cctcggtctc ccaaagtgct gggattacag gtgtgagcca ctgtgcccag   5520

cttatccttt tttcattaca caaaaagact gaatttggtt agttctaagt tggaagataa   5580

agatggtatg cacaggaggc ccttgggagc cctcagataa ctttctcatt cttccagaat   5640

caggctggga tgcattctgt aaattttccc tgcctaggat gtatacctga ggaataaggt   5700

aaggaagatg tcagcaagtc agtctctggt ttacctgcta gctggcatgg atccttaagg   5760

aagcaggagg gagttgggaa gagaggaagg ggtgaagttg gtatctttta aagcgagagt   5820

gattttacct cagattttga agaatactaa ggaatccagt tgttggggta catgctatta   5880

ttagaaggat ctagataatt tgtcctctga gtcatacttg acattgtacc tgtggcacat   5940

caatccgcac tgtttgatac tctggctgaa tctcagcttt caccaacatt gtcaaaggac   6000

cttttttagt gcccagccat gcctaagagt gtgtcatctg aagagggaag catctgcata   6060

ctgctgtcct gattgctcag tcctcactac ctaccagacc cgttggtaag gtacaaaagt   6120

acatgcttgg aaaagcagtc tgcaccacca gtgataagct gtgacagagt ggaacagcct   6180

caatgaaatg aaggaaggat tgctacagtg gcattaagga tggtctctta atcctgtgtt   6240

aaccactaga ttaactttac aatcaactca aaatccttca aaggctttcc actttcttta   6300

gtggcattca gaccccctct agtttgaccc ctacctccaa cttgaacctc tgttactctt   6360

ccgtatgaac attttcctct agccctggac tactagtacc gaagtcacta gtcacatagg   6420

actcatttga aatatgacta gtctcaattg agatgtaatg taagtgtaaa atacacagca   6480

gatttctaag acagcacaca aaatgtaaaa tatgtcaaaa atatttgata ctgattacat   6540

gttgaaatat atgtgttggg ttaaataaaa tgcattaaag ttaa                    6584


<210>  1701
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  1701

Met His Ile Phe Ile Arg Arg Pro Val Ser Ser Trp Phe Leu Gln Leu 
1               5                   10                  15


Ser Gln Asn Asn Thr Phe Leu Phe Pro His Ile Phe Ile Tyr Phe Cys 
            20                  25                  30


Ser Leu Val Tyr Phe Leu Ser Cys Phe His Val Val Tyr Phe Leu Ser 
        35                  40                  45


Val Lys Cys Asn Pro 
    50


<210>  1702
<211>  2779
<212>  DNA
<213>  Homo sapiens

<400>  1702
ggagaaatct aaccctgagg agagcctcag agccgagcag agccccagca tggaggagaa     60

cctgagcata gaggacctgg aattgctaga ggggcgtttc cagcagtgtg tccaagctgt    120

ggcccagctg gaagaggaga gggatcagct catccatgag cttgtattgc tccgggaacc    180

agccctgcag gaggtacagc aagtccatca agacatcctg gctgcctaca agctccatgc    240

ccaagcagag ctggagagag atggcctaag ggaggagatc cggctggtca agcagaagct    300

tttcaaagtg acaaaggaat gtgtggccta ccaataccag ctggagtgcc gccagcagga    360

cgtggctcag tttgccgatt tccgggaagt gctgactaca agggcaaccc agctctcaga    420

ggaactggcc cagctccggg atgcctatca gaagcagaag gagcagctgc ggcaacaact    480

agaagcccct ccaagccaga gggatgggca ctttctccag gaaagccggc gactctctgc    540

ccagtttgaa aatctcatgg cagagagccg ccaggacctg gaggaggagt atgagcctca    600

gttcctgcgg ctcctagaga ggaaagaagc tgggaccaaa gctctgcaga gaacccaggc    660

tgagatccag gaaatgaagg aggctctgag acccctgcaa gcagaggccc ggcagctccg    720

cctgcaaaac aggaacctgg aggaccagat cgcacttgtg aggcaaaaac gagatgaaga    780

ggtgcagcag tacagggaac agctggagga aatggaagaa cgccagaggc agttaagaaa    840

tggggtgcaa ctccagcaac agaagaacaa agagatggaa cagctaaggc tcagtcttgc    900

tgaagagctc tctacttata aggctatgct actacccaag agcctggaac aggctgatgc    960

tcccacttct caggcaggtg gaatggagac acagtctcaa ggggctgttt agaaatatat   1020

ggccaaatct gtaacccgga aacagcaaaa aacttcttag caaaggatca ctaagtaccc   1080

tttggatgta ctcttccaac cagacaagag tgccagaaac ttggcaagca attcatcctg   1140

tggaagttgc aaatactggc tgacctgctt aaaaagattc tagagttggc cggaggcaga   1200

acatgtcaac tctttgctgg attctatttc atctgctgtt gatactgatc tcaatgcacc   1260

aaggaaagga aagatgagcc tcctgtcttc cagcaacaac cctcacatat gcactgagtg   1320

aaggatgaat gtatggacac atctgggagt attttaaaga atgtatcttg ccttgtgttg   1380

acccaaacca aaaacatttt tgaggggcac atgtggggtc aaaaagatag ccaatttcca   1440

ttacatgggt ttacaatttc cattcttttg tgccacgagt gttagaattt aaatgaatac   1500

ttttacaaag tctacttttt gttcaaggat atgctgaccc atatagttta ctcttaaaat   1560

tgtgtcaagg tatttctcac tatactctaa aacaactaga cttgaaaaga aaccatttga   1620

gatttgaatc taatggttaa cgctattcag attttcccaa agatcttacc tcatgaaagt   1680

agttctgggt cagaatgatc tactcagtta aaaaacaaca acaacaaaaa actaagcgat   1740

tgggaaaaaa caggaatttt atctggttat tgcatctggt gatagaggcc ttcaaagcct   1800

attatttcta acctaagtaa aggccccagt gaaaaacata ctggggaaat aaaacctctg   1860

agaaaaggtt caagcacctt ttccaaattt aaatcttgcc ttaaattctc tctaccacac   1920

tgcctttgac actcttggaa gtccatgtag ttctctacag atagacttca aagaaacgtt   1980

accttatcaa agactaatct gtgccacctc tgattcagtg ttttatgtct ttcactttcc   2040

ctgggaagga gtaaagttct tttctacagc tctgggacta ttacatttaa ttctgctctt   2100

gatagtcaaa gaccatggac aacaactgtc atctgaagga ctcttctaga agccagagac   2160

tggtgtttga tggatgtttt atactaaata aaacccatca gcatggggtt atgtagaaaa   2220

gcaatttatt ccattttaag cacttacaca gttagtcatg gagagtaaca ggcctgctgg   2280

tgaaacaggt cacccaaaat ggagatggca tcaaactagt ggtcaaggac taactcctaa   2340

aaaaaaaaag caactcttat caaggattaa tttaattttt aaaacaaata caagttattg   2400

attcactctt ctcaacttga cagtctacct gtggtataac tgtcaggtaa aaacatacat   2460

ctttacaact tggtggtccc aagttaaaaa aaaaaaaaaa aaaaccaaca acaaaaaaaa   2520

aaacaccatt tcacagacag gaaataaaca acatgaaaac agctcaagaa atacactaac   2580

gagcaaaaat atatgaatat atggggaaag aggaacgtgt tgttttgact taactgaaga   2640

aaccaagagg aaactggtct acgtatgaaa atgtgcatcc tggaaagtca ggtgtcaaga   2700

ttttcgagta ggaatctata tgacttgaat ctccccctat ttcctgaata aaagtgacat   2760

ctttcagtat ttatacttc                                                2779


<210>  1703
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  1703

Met Glu Glu Asn Leu Ser Ile Glu Asp Leu Glu Leu Leu Glu Gly Arg 
1               5                   10                  15


Phe Gln Gln Cys Val Gln Ala Val Ala Gln Leu Glu Glu Glu Arg Asp 
            20                  25                  30


Gln Leu Ile His Glu Leu Val Leu Leu Arg Glu Pro Ala Leu Gln Glu 
        35                  40                  45


Val Gln Gln Val His Gln Asp Ile Leu Ala Ala Tyr Lys Leu His Ala 
    50                  55                  60


Gln Ala Glu Leu Glu Arg Asp Gly Leu Arg Glu Glu Ile Arg Leu Val 
65                  70                  75                  80


Lys Gln Lys Leu Phe Lys Val Thr Lys Glu Cys Val Ala Tyr Gln Tyr 
                85                  90                  95


Gln Leu Glu Cys Arg Gln Gln Asp Val Ala Gln Phe Ala Asp Phe Arg 
            100                 105                 110


Glu Val Leu Thr Thr Arg Ala Thr Gln Leu Ser Glu Glu Leu Ala Gln 
        115                 120                 125


Leu Arg Asp Ala Tyr Gln Lys Gln Lys Glu Gln Leu Arg Gln Gln Leu 
    130                 135                 140


Glu Ala Pro Pro Ser Gln Arg Asp Gly His Phe Leu Gln Glu Ser Arg 
145                 150                 155                 160


Arg Leu Ser Ala Gln Phe Glu Asn Leu Met Ala Glu Ser Arg Gln Asp 
                165                 170                 175


Leu Glu Glu Glu Tyr Glu Pro Gln Phe Leu Arg Leu Leu Glu Arg Lys 
            180                 185                 190


Glu Ala Gly Thr Lys Ala Leu Gln Arg Thr Gln Ala Glu Ile Gln Glu 
        195                 200                 205


Met Lys Glu Ala Leu Arg Pro Leu Gln Ala Glu Ala Arg Gln Leu Arg 
    210                 215                 220


Leu Gln Asn Arg Asn Leu Glu Asp Gln Ile Ala Leu Val Arg Gln Lys 
225                 230                 235                 240


Arg Asp Glu Glu Val Gln Gln Tyr Arg Glu Gln Leu Glu Glu Met Glu 
                245                 250                 255


Glu Arg Gln Arg Gln Leu Arg Asn Gly Val Gln Leu Gln Gln Gln Lys 
            260                 265                 270


Asn Lys Glu Met Glu Gln Leu Arg Leu Ser Leu Ala Glu Glu Leu Ser 
        275                 280                 285


Thr Tyr Lys Ala Met Leu Leu Pro Lys Ser Leu Glu Gln Ala Asp Ala 
    290                 295                 300


Pro Thr Ser Gln Ala Gly Gly Met Glu Thr Gln Ser Gln Gly Ala Val 
305                 310                 315                 320


<210>  1704
<211>  2699
<212>  DNA
<213>  Homo sapiens

<400>  1704
ggagaaatct aaccctgagg agagcctcag agccgagcag agccccagca tggaggagaa     60

cctgagcata gaggacctgg aattgctaga ggggcgtttc cagcagtgtg tccaagctgt    120

ggcccagctg gaagaggaga gggatcagct catccatgag cttgtattgc tccgggaacc    180

agccctgcag gaggtacagc aagtccatca agacatcctg gctgcctaca agctccatgc    240

ccaagcagag ctggagagag atggcctaag ggaggagatc cggctggtca agcagaagct    300

tttcaaagtg acaaaggaat gtgtggccta ccaataccag ctggagtgcc gccagcagga    360

cgtggctcag tttgccgatt tccgggaagt gctgactaca agggcaaccc agctctcaga    420

ggaactggcc cagctccggg atgcctatca gaagcagaag gagcagctgc ggcaacaact    480

agaagcccct ccaagccaga gggatgggca ctttctccag gaaagccggc gactctctgc    540

ccagtttgaa aatctcatgg cagagagccg ccaggacctg gaggaggagt atgagcctca    600

gttcctgcgg ctcctagaga ggaaagaagc tgggaccaaa gctctgcaga gaacccaggc    660

tgagatccag gaaatgaagg aggctctgag acccctgcaa gcagaggccc ggcagctccg    720

cctgcaaaac aggaacctgg aggaccagat cgcacttgtg aggcaaaaac gagatgaaga    780

ggtgcagcag tacagggaac agctggagga aatggaagaa cgccagaggc agttaagaaa    840

tggggtgcaa ctccagcaac agaagaacaa agagatggaa cagctaaggc tcagtcttgc    900

tgaagagctc tctacttata agggctgttt agaaatatat ggccaaatct gtaacccgga    960

aacagcaaaa aacttcttag caaaggatca ctaagtaccc tttggatgta ctcttccaac   1020

cagacaagag tgccagaaac ttggcaagca attcatcctg tggaagttgc aaatactggc   1080

tgacctgctt aaaaagattc tagagttggc cggaggcaga acatgtcaac tctttgctgg   1140

attctatttc atctgctgtt gatactgatc tcaatgcacc aaggaaagga aagatgagcc   1200

tcctgtcttc cagcaacaac cctcacatat gcactgagtg aaggatgaat gtatggacac   1260

atctgggagt attttaaaga atgtatcttg ccttgtgttg acccaaacca aaaacatttt   1320

tgaggggcac atgtggggtc aaaaagatag ccaatttcca ttacatgggt ttacaatttc   1380

cattcttttg tgccacgagt gttagaattt aaatgaatac ttttacaaag tctacttttt   1440

gttcaaggat atgctgaccc atatagttta ctcttaaaat tgtgtcaagg tatttctcac   1500

tatactctaa aacaactaga cttgaaaaga aaccatttga gatttgaatc taatggttaa   1560

cgctattcag attttcccaa agatcttacc tcatgaaagt agttctgggt cagaatgatc   1620

tactcagtta aaaaacaaca acaacaaaaa actaagcgat tgggaaaaaa caggaatttt   1680

atctggttat tgcatctggt gatagaggcc ttcaaagcct attatttcta acctaagtaa   1740

aggccccagt gaaaaacata ctggggaaat aaaacctctg agaaaaggtt caagcacctt   1800

ttccaaattt aaatcttgcc ttaaattctc tctaccacac tgcctttgac actcttggaa   1860

gtccatgtag ttctctacag atagacttca aagaaacgtt accttatcaa agactaatct   1920

gtgccacctc tgattcagtg ttttatgtct ttcactttcc ctgggaagga gtaaagttct   1980

tttctacagc tctgggacta ttacatttaa ttctgctctt gatagtcaaa gaccatggac   2040

aacaactgtc atctgaagga ctcttctaga agccagagac tggtgtttga tggatgtttt   2100

atactaaata aaacccatca gcatggggtt atgtagaaaa gcaatttatt ccattttaag   2160

cacttacaca gttagtcatg gagagtaaca ggcctgctgg tgaaacaggt cacccaaaat   2220

ggagatggca tcaaactagt ggtcaaggac taactcctaa aaaaaaaaag caactcttat   2280

caaggattaa tttaattttt aaaacaaata caagttattg attcactctt ctcaacttga   2340

cagtctacct gtggtataac tgtcaggtaa aaacatacat ctttacaact tggtggtccc   2400

aagttaaaaa aaaaaaaaaa aaaaccaaca acaaaaaaaa aaacaccatt tcacagacag   2460

gaaataaaca acatgaaaac agctcaagaa atacactaac gagcaaaaat atatgaatat   2520

atggggaaag aggaacgtgt tgttttgact taactgaaga aaccaagagg aaactggtct   2580

acgtatgaaa atgtgcatcc tggaaagtca ggtgtcaaga ttttcgagta ggaatctata   2640

tgacttgaat ctccccctat ttcctgaata aaagtgacat ctttcagtat ttatacttc    2699


<210>  1705
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  1705

Met Glu Glu Asn Leu Ser Ile Glu Asp Leu Glu Leu Leu Glu Gly Arg 
1               5                   10                  15


Phe Gln Gln Cys Val Gln Ala Val Ala Gln Leu Glu Glu Glu Arg Asp 
            20                  25                  30


Gln Leu Ile His Glu Leu Val Leu Leu Arg Glu Pro Ala Leu Gln Glu 
        35                  40                  45


Val Gln Gln Val His Gln Asp Ile Leu Ala Ala Tyr Lys Leu His Ala 
    50                  55                  60


Gln Ala Glu Leu Glu Arg Asp Gly Leu Arg Glu Glu Ile Arg Leu Val 
65                  70                  75                  80


Lys Gln Lys Leu Phe Lys Val Thr Lys Glu Cys Val Ala Tyr Gln Tyr 
                85                  90                  95


Gln Leu Glu Cys Arg Gln Gln Asp Val Ala Gln Phe Ala Asp Phe Arg 
            100                 105                 110


Glu Val Leu Thr Thr Arg Ala Thr Gln Leu Ser Glu Glu Leu Ala Gln 
        115                 120                 125


Leu Arg Asp Ala Tyr Gln Lys Gln Lys Glu Gln Leu Arg Gln Gln Leu 
    130                 135                 140


Glu Ala Pro Pro Ser Gln Arg Asp Gly His Phe Leu Gln Glu Ser Arg 
145                 150                 155                 160


Arg Leu Ser Ala Gln Phe Glu Asn Leu Met Ala Glu Ser Arg Gln Asp 
                165                 170                 175


Leu Glu Glu Glu Tyr Glu Pro Gln Phe Leu Arg Leu Leu Glu Arg Lys 
            180                 185                 190


Glu Ala Gly Thr Lys Ala Leu Gln Arg Thr Gln Ala Glu Ile Gln Glu 
        195                 200                 205


Met Lys Glu Ala Leu Arg Pro Leu Gln Ala Glu Ala Arg Gln Leu Arg 
    210                 215                 220


Leu Gln Asn Arg Asn Leu Glu Asp Gln Ile Ala Leu Val Arg Gln Lys 
225                 230                 235                 240


Arg Asp Glu Glu Val Gln Gln Tyr Arg Glu Gln Leu Glu Glu Met Glu 
                245                 250                 255


Glu Arg Gln Arg Gln Leu Arg Asn Gly Val Gln Leu Gln Gln Gln Lys 
            260                 265                 270


Asn Lys Glu Met Glu Gln Leu Arg Leu Ser Leu Ala Glu Glu Leu Ser 
        275                 280                 285


Thr Tyr Lys Gly Cys Leu Glu Ile Tyr Gly Gln Ile Cys Asn Pro Glu 
    290                 295                 300


Thr Ala Lys Asn Phe Leu Ala Lys Asp His 
305                 310


<210>  1706
<211>  1100
<212>  DNA
<213>  Homo sapiens

<400>  1706
tcctagaaaa ttagaaaaag caacaatagt tacttgtgta tccttttttc attacacaaa     60

aagactgaat ttggttagtt ctaagttgga agataaagat ggtatgcaca ggaggccctt    120

gggagccctc agataacttt ctcattcttc cagaatcagg ctgggatgca ttctgtaaat    180

tttccctgcc taggatgtat acctgaggaa taaggtaagg aagatgtcag caagtcagtc    240

tctggtttac ctgctagctg gcatggatcc ttaaggaagc aggagggagt tgggaagaga    300

ggaaggggtg aagttggtat cttttaaagc gagagtgatt ttacctcaga ttttgaagaa    360

tactaaggaa tccagttgtt ggggtacatg ctattattag aaggatctag ataatttgtc    420

ctctgagtca tacttgacat tgtacctgtg gcacatcaat ccgcactgtt tgatactctg    480

gctgaatctc agctttcacc aacattgtca aaggaccttt tttagtgccc agccatgcct    540

aagagtgtgt catctgaaga gggaagcatc tgcatactgc tgtcctgatt gctcagtcct    600

cactacctac cagacccgtt ggtaaggtac aaaagtacat gcttggaaaa gcagtctgca    660

ccaccagtga taagctgtga cagagtggaa cagcctcaat gaaatgaagg aaggattgct    720

acagtggcat taaggatggt ctcttaatcc tgtgttaacc actagattaa ctttacaatc    780

aactcaaaat ccttcaaagg ctttccactt tctttagtgg cattcagacc ccctctagtt    840

tgacccctac ctccaacttg aacctctgtt actcttccgt atgaacattt tcctctagcc    900

ctggactact agtaccgaag tcactagtca cataggactc atttgaaata tgactagtct    960

caattgagat gtaatgtaag tgtaaaatac acagcagatt tctaagacag cacacaaaat   1020

gtaaaatatg tcaaaaatat ttgatactga ttacatgttg aaatatatgt gttgggttaa   1080

ataaaatgca ttaaagttaa                                               1100


<210>  1707
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  1707

Met Val Cys Thr Gly Gly Pro Trp Glu Pro Ser Asp Asn Phe Leu Ile 
1               5                   10                  15


Leu Pro Glu Ser Gly Trp Asp Ala Phe Cys Lys Phe Ser Leu Pro Arg 
            20                  25                  30


Met Tyr Thr 
        35


<210>  1708
<211>  2226
<212>  DNA
<213>  Homo sapiens

<400>  1708
cactgctctg ccttacctct gtcttcttat ttttcaaatg ccttatacct aactcataga     60

gatgtaagga ctaaaggaat tattttgtgt aaagaacttc aagtacatac tagctattgt    120

tgatctatga aatgtcccct cttttgccca ggctggggta gtcatgcctg ttttcatcag    180

gacagtgcct tatcactaca gctattacag tgcttataac attgaaatat gtttaattga    240

tgccaagact gccacatttt aacatctctg atcaggatgc atgttaaaat caacagtgct    300

tagattttac gaaatacatt cattttgtct gttatgcttc cttctggagt acaaactttt    360

tttaaggcgg agtctttgtc gcccaggctg gagtgcagtg gcgcgatctc aacctccacc    420

ttgcgggttc aggcaattct gcctcagccc ccgagtagct gggattacag gcatgcacca    480

ccacgcccgg ctaatttttt gtatttttag cgagacaggg tttcaccgtg ttagccagga    540

tggtctcgat ctcctgacct catgatccac tcgcctctgc ctcccaaagt gctgggatca    600

caggcatggg ccactgcacc cggcctctgg agtacaaact ctttgagggc aggagcatta    660

cccccacccc gcaacacaca cacacttttt tttttctttt ctgagacgga acaccgtcac    720

aaaaaaaaaa aaaaaaaagt aagttgatga aatagaactt tagcaaacag tttaggaagc    780

catttcagaa agaaaaatta gggacctcag accttgcttc ctactttaat gatggtatag    840

caacaagaga agctattata ctaccaagag tgtatcaggc cagataaagt ggctcacacc    900

tgtaatctca gcaactcggg aggctgaggc aggaagacca agacttcctc tcaatagaga    960

aagattcatt tgatagagat tagatagact tctgaatatt ctttttaaaa ctttgtgtca   1020

taagattatc tttggaaaac aatccttggg aagatgcaca aatcgtcaaa tctgaaacca   1080

tcttaacctc ttccttagag tagctttcta attattctcc attgctctgc atctctagcc   1140

cactttatat cctgccacca gtacttcttg taatcccagc acattgggag gccgagacgg   1200

gtggatcacg aggtcaggag ttggagacca acctggccaa gatggtgaag ccccatctct   1260

actaaaaata caaaaattag cgaggcctgg tggcgggcac ctgtaatccc agctacttgg   1320

gaggctgagg caggagaatc acttgacccg ggaggcggag atttcggtga gccaagatca   1380

tgccactgca ctctagcctg agtgacagag caagactcca tctccaaaga aaaaaaaaaa   1440

aaaaagtaga gaggcaggca gtggctcaag cctgtaatcc cagcactttg ggaggccgag   1500

ccaggcagat cacctgaggt caggagttca agaccagctg gctaacatgg taaaacttca   1560

tctctaccaa aaacacgaaa attagggccg ggcgtggtga ctcatgcctg taatcccagc   1620

actttgggag gccgaggcag gcagactgcc tgagctcagg agttcaagac catcctgggc   1680

aatacggtga aaccccgtcc ctactataca aacaattggc cgggctcagt ggctcacacc   1740

tataatccca gtactttggg aggccgaggc aggtggatca tgaggtcagg agatcaagac   1800

catcctggct aacatagtga aacactgtct ctaataaaaa tagaaaaaat tagccagcta   1860

tggtggcatg cacctgtagt cccagctact cgggaggctg aggcaggaaa atcgcttgaa   1920

cccaggaggc agaggttgca gtgagcccag atcatgccac tgcactccag cctgggtgac   1980

agagcgagac tccttctcaa aaaacaaaaa aaaacaacaa aaaaaatttg ccaggcgtgg   2040

cactgtgcac ctgtagtccc agctactcgg gaggctgagg caggagaact gcttgaaccc   2100

gggaggtaga ggttgcaatg agccgagatc acgctattgc actccagcct aggcaataga   2160

agagactccg actaaaaaaa aattagccac gtccatggtg ttaggcgcct gtaatcccag   2220

ctactt                                                              2226


<210>  1709
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  1709

Met Ile His Ser Pro Leu Pro Pro Lys Val Leu Gly Ser Gln Ala Trp 
1               5                   10                  15


Ala Thr Ala Pro Gly Leu Trp Ser Thr Asn Ser Leu Arg Ala Gly Ala 
            20                  25                  30


Leu Pro Pro Pro Arg Asn Thr His Thr Leu Phe Phe Phe Phe Ser Glu 
        35                  40                  45


Thr Glu His Arg His Lys Lys Lys Lys Lys Lys Val Ser 
    50                  55                  60


<210>  1710
<211>  1157
<212>  DNA
<213>  Homo sapiens

<400>  1710
cctttgagca gcccgcccaa ccctgcctcc accctcccag gctggacagg gaaggtgctc     60

cctggggctt cagacccccc ttctgactcc ccctgcaacg ggacctcacg aaaggaaggg    120

tggagagaag gaaaacaaga gtagaggcca attctcctct tccaaagaac tctggatccc    180

taaatgaggc agaagccttg aacccagaag ttactctatc ttcagagggg tccttaaacc    240

tcgaagacat tctctacctg gaggacacag gtgaccttga tgagacactc tatgtgcaag    300

agactgagaa ggcagaggag gccctgtata ttgaggaggc catgcagcca gatgaggctc    360

tgcatgtgga ggagcctggg aatccagagg agacagtgtg tgtggaggaa accacggagc    420

cagatcggat acagtttgtg gaggggcccg tggagccagg aaagcccaca agcccagagc    480

acgttgttta tgagggagag acagtcacaa gggcggagaa atctaaccct gaggagagcc    540

tcagagccga gcagagcccc agcatggagg agaacctgag catagaggac ctggaattgc    600

tagaggggcg tttccagcag tgtgtccaag ctgtggccca gctggaagag gagagggatc    660

agctcatcca tgagcttgta ttgctccggg aaccagccct gcaggaggta cagcaagtcc    720

atcaagacat cctggctgcc tacaagctcc atgcccaagc agagctggag agagatggcc    780

taagggagga gatccggctg gtcaagcaga agcttttcaa agtgacaaag gaatgtgtgg    840

cctaccaata ccagctggag tgccgccagc aggacgtggc tcagtttgcc gatttccggg    900

aagtgctgac tacaagggca acccagctct cagaggaact ggcccagctc cgggatgcct    960

atcagaagca gaaggagcag ctgcggcaac aactagaagc ccctccaagc cagagggatg   1020

ggcactttct ccaggaaagc cggcgactct ctgcccagtt tgaaaatctc atggcagaga   1080

gccgccagga cctggaggag gagtatgagc ctcagttcct gcggctccta gagaggaaag   1140

aagctgggac caaagct                                                  1157


<210>  1711
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  1711

Met Gln Pro Asp Glu Ala Leu His Val Glu Glu Pro Gly Asn Pro Glu 
1               5                   10                  15


Glu Thr Val Cys Val Glu Glu Thr Thr Glu Pro Asp Arg Ile Gln Phe 
            20                  25                  30


Val Glu Gly Pro Val Glu Pro Gly Lys Pro Thr Ser Pro Glu His Val 
        35                  40                  45


Val Tyr Glu Gly Glu Thr Val Thr Arg Ala Glu Lys Ser Asn Pro Glu 
    50                  55                  60


Glu Ser Leu Arg Ala Glu Gln Ser Pro Ser Met Glu Glu Asn Leu Ser 
65                  70                  75                  80


Ile Glu Asp Leu Glu Leu Leu Glu Gly Arg Phe Gln Gln Cys Val Gln 
                85                  90                  95


Ala Val Ala Gln Leu Glu Glu Glu Arg Asp Gln Leu Ile His Glu Leu 
            100                 105                 110


Val Leu Leu Arg Glu Pro Ala Leu Gln Glu Val Gln Gln Val His Gln 
        115                 120                 125


Asp Ile Leu Ala Ala Tyr Lys Leu His Ala Gln Ala Glu Leu Glu Arg 
    130                 135                 140


Asp Gly Leu Arg Glu Glu Ile Arg Leu Val Lys Gln Lys Leu Phe Lys 
145                 150                 155                 160


Val Thr Lys Glu Cys Val Ala Tyr Gln Tyr Gln Leu Glu Cys Arg Gln 
                165                 170                 175


Gln Asp Val Ala Gln Phe Ala Asp Phe Arg Glu Val Leu Thr Thr Arg 
            180                 185                 190


Ala Thr Gln Leu Ser Glu Glu Leu Ala Gln Leu Arg Asp Ala Tyr Gln 
        195                 200                 205


Lys Gln Lys Glu Gln Leu Arg Gln Gln Leu Glu Ala Pro Pro Ser Gln 
    210                 215                 220


Arg Asp Gly His Phe Leu Gln Glu Ser Arg Arg Leu Ser Ala Gln Phe 
225                 230                 235                 240


Glu Asn Leu Met Ala Glu Ser Arg Gln Asp Leu Glu Glu Glu Tyr Glu 
                245                 250                 255


Pro Gln Phe Leu Arg Leu Leu Glu Arg Lys Glu Ala Gly Thr Lys 
            260                 265                 270


<210>  1712
<211>  1539
<212>  DNA
<213>  Homo sapiens

<400>  1712
cggacacccc caaacactcg cgggagaggg gtgctggctc cctttgagca gcccgcccaa     60

ccctgcctcc accctcccag gctggacagg gaaggtgctc cctggggctt cagacccccc    120

ttctgactcc ccctgcaacg ggacctcacg aaaggaaggg tggagagaag gttcgggaag    180

acgagggggc tgggaggttt ggaaagacag ctccaggccc ccgttcccac ccccgcccca    240

ggctggtccg ggaggggcag cctctccccg cccccaggtc cgcgcggccg ctccctcctc    300

ccccggcagg agccccggcc aagtgggcgc gcccggcccg gggccggccg ggatccggtg    360

tcggttgcag ctggcagtgc ggcgggcgcg ggcgccggag cgaggggccc gcgggcccgg    420

ctattaataa cgcggccgcc agcccggggt cgcgcagcca tggccagccc ggagccccgg    480

cgcggcgggg acggcgccgc ccaggccgcg aggaaaacaa gagtagaggc caattctcct    540

cttccaaaga actctggatc cctaaatgag gcagaagcct tgaacccaga agttactcta    600

tcttcagagg ggtccttaaa cctcgaagac attctctacc tggaggacac aggtgacctt    660

gatgagacac tctatgtgca agagactgag aaggcagagg aggccctgta tattgaggag    720

gccatgcagc cagatgaggc tctgcatgtg gaggagcctg ggaatccaga ggagacagtg    780

tgtgtggagg aaaccacgga gccagatcgg atacagtttg tggaggggcc cgtggagcca    840

ggaaagccca caagcccaga gcacgttgtt tatgagggag agacagtcac aagggcggag    900

aaatctaacc ctgaggagag cctcagagcc gagcagagcc ccagcatgga ggagaacctg    960

agcatagagg acctggaatt gctagagggg cgtttccagc agtgtgtcca agctgtggcc   1020

cagctggaag aggagaggga tcagctcatc catgagcttg tattgctccg ggaaccagcc   1080

ctgcaggagg tacagcaagt ccatcaagac atcctggctg cctacaagct ccatgcccaa   1140

gcagagctgg agagagatgg cctaagggag gagatccggc tggtcaagca gaagcttttc   1200

aaagtgacaa aggaatgtgt ggcctaccaa taccagctgg agtgccgcca gcaggacgtg   1260

gctcagtttg ccgatttccg ggaagtgctg actacaaggg caacccagct ctcagaggaa   1320

ctggcccagc tccgggatgc ctatcagaag cagaaggagc agctgcggca acaactagaa   1380

gcccctccaa gccagaggga tgggcacttt ctccaggaaa gccggcgact ctctgcccag   1440

tttgaaaatc tcatggcaga gagccgccag gacctggagg aggagtatga gcctcagttc   1500

ctgcggctcc tagagaggaa agaagctggg accaaagct                          1539


<210>  1713
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  1713

Met Ala Ser Pro Glu Pro Arg Arg Gly Gly Asp Gly Ala Ala Gln Ala 
1               5                   10                  15


Ala Arg Lys Thr Arg Val Glu Ala Asn Ser Pro Leu Pro Lys Asn Ser 
            20                  25                  30


Gly Ser Leu Asn Glu Ala Glu Ala Leu Asn Pro Glu Val Thr Leu Ser 
        35                  40                  45


Ser Glu Gly Ser Leu Asn Leu Glu Asp Ile Leu Tyr Leu Glu Asp Thr 
    50                  55                  60


Gly Asp Leu Asp Glu Thr Leu Tyr Val Gln Glu Thr Glu Lys Ala Glu 
65                  70                  75                  80


Glu Ala Leu Tyr Ile Glu Glu Ala Met Gln Pro Asp Glu Ala Leu His 
                85                  90                  95


Val Glu Glu Pro Gly Asn Pro Glu Glu Thr Val Cys Val Glu Glu Thr 
            100                 105                 110


Thr Glu Pro Asp Arg Ile Gln Phe Val Glu Gly Pro Val Glu Pro Gly 
        115                 120                 125


Lys Pro Thr Ser Pro Glu His Val Val Tyr Glu Gly Glu Thr Val Thr 
    130                 135                 140


Arg Ala Glu Lys Ser Asn Pro Glu Glu Ser Leu Arg Ala Glu Gln Ser 
145                 150                 155                 160


Pro Ser Met Glu Glu Asn Leu Ser Ile Glu Asp Leu Glu Leu Leu Glu 
                165                 170                 175


Gly Arg Phe Gln Gln Cys Val Gln Ala Val Ala Gln Leu Glu Glu Glu 
            180                 185                 190


Arg Asp Gln Leu Ile His Glu Leu Val Leu Leu Arg Glu Pro Ala Leu 
        195                 200                 205


Gln Glu Val Gln Gln Val His Gln Asp Ile Leu Ala Ala Tyr Lys Leu 
    210                 215                 220


His Ala Gln Ala Glu Leu Glu Arg Asp Gly Leu Arg Glu Glu Ile Arg 
225                 230                 235                 240


Leu Val Lys Gln Lys Leu Phe Lys Val Thr Lys Glu Cys Val Ala Tyr 
                245                 250                 255


Gln Tyr Gln Leu Glu Cys Arg Gln Gln Asp Val Ala Gln Phe Ala Asp 
            260                 265                 270


Phe Arg Glu Val Leu Thr Thr Arg Ala Thr Gln Leu Ser Glu Glu Leu 
        275                 280                 285


Ala Gln Leu Arg Asp Ala Tyr Gln Lys Gln Lys Glu Gln Leu Arg Gln 
    290                 295                 300


Gln Leu Glu Ala Pro Pro Ser Gln Arg Asp Gly His Phe Leu Gln Glu 
305                 310                 315                 320


Ser Arg Arg Leu Ser Ala Gln Phe Glu Asn Leu Met Ala Glu Ser Arg 
                325                 330                 335


Gln Asp Leu Glu Glu Glu Tyr Glu Pro Gln Phe Leu Arg Leu Leu Glu 
            340                 345                 350


Arg Lys Glu Ala Gly Thr Lys 
        355


<210>  1714
<211>  1468
<212>  DNA
<213>  Homo sapiens

<400>  1714
aagtggaaaa aggaatccga aggaagaacg cctgaagccc aggtctggga aggggcccag     60

cagcttctct cttggggaga aagacgtcag tgctggtttg accctcacac tagtgggctg    120

aggacgtggg gggagggtct ctgttgccca ggctggggtg cagagtggtg cagtcatggc    180

tcagcacagc ctcgacctcc caggctcaga gatggggttt cgccatgttg cccacgctgg    240

ccttaaactc ctggactcaa gaggtcttgg cctcccaaag tgctggatta cagacatgag    300

ccaccgcact tgaccacggt tatctttttt ttttttttga gacggagttt cgctgttgtt    360

gcccaggctg gagtgcaatg gtgcaatctc gtctcactgc aacctctgcc tctttgaagt    420

tcaagagatt ctcctgcctc agaaaacaag agtagaggcc aattctcctc ttccaaagaa    480

ctctggatcc ctaaatgagg cagaagcctt gaacccagaa gttactctat cttcagaggg    540

gtccttaaac ctcgaagaca ttctctacct ggaggacaca ggtgaccttg atgagacact    600

ctatgtgcaa gagactgaga aggcagagga ggccctgtat attgaggagg ccatgcagcc    660

agatgaggct ctgcatgtgg aggagcctgg gaatccagag gagacagtgt gtgtggagga    720

aaccacggag ccagatcgga tacagtttgt ggaggggccc gtggagccag gaaagcccac    780

aagcccagag cacgttgttt atgagggaga gacagtcaca agggcggaga aatctaaccc    840

tgaggagagc ctcagagccg agcagagccc cagcatggag gagaacctga gcatagagga    900

cctggaattg ctagaggggc gtttccagca gtgtgtccaa gctgtggccc agctggaaga    960

ggagagggat cagctcatcc atgagcttgt attgctccgg gaaccagccc tgcaggaggt   1020

acagcaagtc catcaagaca tcctggctgc ctacaagctc catgcccaag cagagctgga   1080

gagagatggc ctaagggagg agatccggct ggtcaagcag aagcttttca aagtgacaaa   1140

ggaatgtgtg gcctaccaat accagctgga gtgccgccag caggacgtgg ctcagtttgc   1200

cgatttccgg gaagtgctga ctacaagggc aacccagctc tcagaggaac tggcccagct   1260

ccgggatgcc tatcagaagc agaaggagca gctgcggcaa caactagaag cccctccaag   1320

ccagagggat gggcactttc tccaggaaag ccggcgactc tctgcccagt ttgaaaatct   1380

catggcagag agccgccagg acctggagga ggagtatgag cctcagttcc tgcggctcct   1440

agagaggaaa gaagctggga ccaaagct                                      1468


<210>  1715
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  1715

Met Ala Gln His Ser Leu Asp Leu Pro Gly Ser Glu Met Gly Phe Arg 
1               5                   10                  15


His Val Ala His Ala Gly Leu Lys Leu Leu Asp Ser Arg Gly Leu Gly 
            20                  25                  30


Leu Pro Lys Cys Trp Ile Thr Asp Met Ser His Arg Thr 
        35                  40                  45


<210>  1716
<211>  1116
<212>  DNA
<213>  Homo sapiens

<400>  1716
agctaagtgg aaaaaggaat ccgaaggaag aacgcctgaa gcccaggtct gggaaggggc     60

ccagcagctt ctctcttggg gagaaagacg aaaacaagag tagaggccaa ttctcctctt    120

ccaaagaact ctggatccct aaatgaggca gaagccttga acccagaagt tactctatct    180

tcagaggggt ccttaaacct cgaagacatt ctctacctgg aggacacagg tgaccttgat    240

gagacactct atgtgcaaga gactgagaag gcagaggagg ccctgtatat tgaggaggcc    300

atgcagccag atgaggctct gcatgtggag gagcctggga atccagagga gacagtgtgt    360

gtggaggaaa ccacggagcc agatcggata cagtttgtgg aggggcccgt ggagccagga    420

aagcccacaa gcccagagca cgttgtttat gagggagaga cagtcacaag ggcggagaaa    480

tctaaccctg aggagagcct cagagccgag cagagcccca gcatggagga gaacctgagc    540

atagaggacc tggaattgct agaggggcgt ttccagcagt gtgtccaagc tgtggcccag    600

ctggaagagg agagggatca gctcatccat gagcttgtat tgctccggga accagccctg    660

caggaggtac agcaagtcca tcaagacatc ctggctgcct acaagctcca tgcccaagca    720

gagctggaga gagatggcct aagggaggag atccggctgg tcaagcagaa gcttttcaaa    780

gtgacaaagg aatgtgtggc ctaccaatac cagctggagt gccgccagca ggacgtggct    840

cagtttgccg atttccggga agtgctgact acaagggcaa cccagctctc agaggaactg    900

gcccagctcc gggatgccta tcagaagcag aaggagcagc tgcggcaaca actagaagcc    960

cctccaagcc agagggatgg gcactttctc caggaaagcc ggcgactctc tgcccagttt   1020

gaaaatctca tggcagagag ccgccaggac ctggaggagg agtatgagcc tcagttcctg   1080

cggctcctag agaggaaaga agctgggacc aaagct                             1116


<210>  1717
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  1717

Met Gln Pro Asp Glu Ala Leu His Val Glu Glu Pro Gly Asn Pro Glu 
1               5                   10                  15


Glu Thr Val Cys Val Glu Glu Thr Thr Glu Pro Asp Arg Ile Gln Phe 
            20                  25                  30


Val Glu Gly Pro Val Glu Pro Gly Lys Pro Thr Ser Pro Glu His Val 
        35                  40                  45


Val Tyr Glu Gly Glu Thr Val Thr Arg Ala Glu Lys Ser Asn Pro Glu 
    50                  55                  60


Glu Ser Leu Arg Ala Glu Gln Ser Pro Ser Met Glu Glu Asn Leu Ser 
65                  70                  75                  80


Ile Glu Asp Leu Glu Leu Leu Glu Gly Arg Phe Gln Gln Cys Val Gln 
                85                  90                  95


Ala Val Ala Gln Leu Glu Glu Glu Arg Asp Gln Leu Ile His Glu Leu 
            100                 105                 110


Val Leu Leu Arg Glu Pro Ala Leu Gln Glu Val Gln Gln Val His Gln 
        115                 120                 125


Asp Ile Leu Ala Ala Tyr Lys Leu His Ala Gln Ala Glu Leu Glu Arg 
    130                 135                 140


Asp Gly Leu Arg Glu Glu Ile Arg Leu Val Lys Gln Lys Leu Phe Lys 
145                 150                 155                 160


Val Thr Lys Glu Cys Val Ala Tyr Gln Tyr Gln Leu Glu Cys Arg Gln 
                165                 170                 175


Gln Asp Val Ala Gln Phe Ala Asp Phe Arg Glu Val Leu Thr Thr Arg 
            180                 185                 190


Ala Thr Gln Leu Ser Glu Glu Leu Ala Gln Leu Arg Asp Ala Tyr Gln 
        195                 200                 205


Lys Gln Lys Glu Gln Leu Arg Gln Gln Leu Glu Ala Pro Pro Ser Gln 
    210                 215                 220


Arg Asp Gly His Phe Leu Gln Glu Ser Arg Arg Leu Ser Ala Gln Phe 
225                 230                 235                 240


Glu Asn Leu Met Ala Glu Ser Arg Gln Asp Leu Glu Glu Glu Tyr Glu 
                245                 250                 255


Pro Gln Phe Leu Arg Leu Leu Glu Arg Lys Glu Ala Gly Thr Lys 
            260                 265                 270


<210>  1718
<211>  395
<212>  DNA
<213>  Homo sapiens

<400>  1718
gctgtgtggg gcagtctggg agaggagcgc ctctgccact gtaacaacta gcctttgctg     60

gactgcctcg cccactccag ctggggtgct tcacttctgt gattgccttt aatgctccga    120

acagccctgg gaagtagggc cgatcacctc caattcacag gttcaaagtc cctgggttgg    180

ggacactgac ggggctggac atggccaggg attccaccag gggctttaag agtcatggaa    240

ttgccgggcg ctgtggctca cacctgtaat cccaggagtt tgggaggctg aggcaggagg    300

atcacttgag cccagaagct tgagaccagc ctagacaaca acgtgagacc ctgtctctac    360

aaagaaataa aattagctgg gtgtggtggt gcaca                               395


<210>  1719
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  1719

Cys Ser Glu Gln Pro Trp Glu Val Gly Pro Ile Thr Ser Asn Ser Gln 
1               5                   10                  15


Val Gln Ser Pro Trp Val Gly Asp Thr Asp Gly Ala Gly His Gly Gln 
            20                  25                  30


Gly Phe His Gln Gly Leu 
        35


<210>  1720
<211>  1865
<212>  DNA
<213>  Homo sapiens

<400>  1720
gcggccgccc ccggcatggg caccgcgccg cagggggcct gacccgccgc ccgctccgcc     60

cccgcctgcc atggcggccc gcgcgccccc cgccgcacct gcggccgagg agccggggaa    120

cccgggcggc cccccgcgca ggaagaagtc ccgctccggc gcgtccggcc tccgccgcgc    180

cttcagctgg ctgcggggca agcggcgcaa gaagaaggcg gcgggggccg agggcgccga    240

accggccgcc ccccgggcca agaaggcgga ggacaaggcc aagagggcca agggcaaagg    300

ccgaggctct gccaaggctg agaatgacaa acatctaagt gtagggcctg gccaggggcc    360

agggtctgca gtggatgagc accaggacaa cgtcttcttt cccagtgggc gaccccccca    420

cctggaagag ctgcacactc aggcccagga ggggctccgc tccctacaac accaagagaa    480

acagaaactg aacaagggtg gctgggacca tggagacacc cagagtatcc agtcctcccg    540

gacggggccg gatgaagaca acatctcctt ctgcagtcag accacatcct acgtggctga    600

gagctccaca gcagaggacg cgctctccat ccgctcggag atgatccagc gcaaaggctc    660

caccttccga ccccatgact catttcccaa atctggaaag tcagggcggc gtcggcggga    720

gcggcggagc actgtgctgg gactcccgca gcatgtgcag aaggagcttg gcctgaggaa    780

tgagcgtgag gcaccaggca cgccccgggc tcctggtgca cgggatgccg tacgcatccc    840

cacagtggac ggccgccccc gaggcacctc agggatgggg gcccgggtgt ccctgcaggc    900

gctggaggcg gaggcggagg ctggcgctga gacagaggcc atgctgcagc gccacattga    960

ccgtgtctac cgggatgaca cctttgttgg ccggtccacg ggtacccggg ccccaccatt   1020

gacccggccc atgtccctag cagtgcctgg attgacagga ggggcagggc ctgcagagcc   1080

cctgagcccg gccatgtcca tctcccccca ggccacctac ctgtcgaagt tgattccaca   1140

tgctgtgctg ccgcctacag tggacgtggt ggccctaggc cgctgcagcc tgcgcacact   1200

aagccgctgc agcctgcact cggccagccc agcctcagtc cgctcgctgg ggcgcttctc   1260

ctccgtctcc agcccacagc cccgcagccg ccacccatcc tcctccagtg acacctggag   1320

ccactctcaa tcctccgaca ccattgtgtc tgacggttcc accctctcct ctaagggtgg   1380

ctctgagggc cagccggaga gctctacggc tagcaatagc gtggtacccc ctccccaggg   1440

aggcagtggg aggggctctc ccagtggggg cagcactgct gaggcctcag acacactcag   1500

cattcggagc agtgggcagt tgtctggccg gagtgtgtcc ctgcgtaagc tgaagcggcc   1560

tccaccccct ccccgccgga cccactccct ccatcagcgg ggcttagcag tgcctgatgg   1620

gccattaggg ttgcccccta agcctgagcg taagcagcag ccccagctgc ctcggccacc   1680

caccactggt ggctcagaag gggcgggggc agcaccctgt ccacccaacc cagccaacag   1740

ctgggtacct ggcttgtctc cgggtggttc ccggcgcccc ccacggtccc cagaacggac   1800

actttcgccc tccagtggat actcgagcca aagtggtact cccaccctcc ctcccaaggg   1860

cctgg                                                               1865


<210>  1721
<211>  597
<212>  PRT
<213>  Homo sapiens

<400>  1721

Met Ala Ala Arg Ala Pro Pro Ala Ala Pro Ala Ala Glu Glu Pro Gly 
1               5                   10                  15


Asn Pro Gly Gly Pro Pro Arg Arg Lys Lys Ser Arg Ser Gly Ala Ser 
            20                  25                  30


Gly Leu Arg Arg Ala Phe Ser Trp Leu Arg Gly Lys Arg Arg Lys Lys 
        35                  40                  45


Lys Ala Ala Gly Ala Glu Gly Ala Glu Pro Ala Ala Pro Arg Ala Lys 
    50                  55                  60


Lys Ala Glu Asp Lys Ala Lys Arg Ala Lys Gly Lys Gly Arg Gly Ser 
65                  70                  75                  80


Ala Lys Ala Glu Asn Asp Lys His Leu Ser Val Gly Pro Gly Gln Gly 
                85                  90                  95


Pro Gly Ser Ala Val Asp Glu His Gln Asp Asn Val Phe Phe Pro Ser 
            100                 105                 110


Gly Arg Pro Pro His Leu Glu Glu Leu His Thr Gln Ala Gln Glu Gly 
        115                 120                 125


Leu Arg Ser Leu Gln His Gln Glu Lys Gln Lys Leu Asn Lys Gly Gly 
    130                 135                 140


Trp Asp His Gly Asp Thr Gln Ser Ile Gln Ser Ser Arg Thr Gly Pro 
145                 150                 155                 160


Asp Glu Asp Asn Ile Ser Phe Cys Ser Gln Thr Thr Ser Tyr Val Ala 
                165                 170                 175


Glu Ser Ser Thr Ala Glu Asp Ala Leu Ser Ile Arg Ser Glu Met Ile 
            180                 185                 190


Gln Arg Lys Gly Ser Thr Phe Arg Pro His Asp Ser Phe Pro Lys Ser 
        195                 200                 205


Gly Lys Ser Gly Arg Arg Arg Arg Glu Arg Arg Ser Thr Val Leu Gly 
    210                 215                 220


Leu Pro Gln His Val Gln Lys Glu Leu Gly Leu Arg Asn Glu Arg Glu 
225                 230                 235                 240


Ala Pro Gly Thr Pro Arg Ala Pro Gly Ala Arg Asp Ala Val Arg Ile 
                245                 250                 255


Pro Thr Val Asp Gly Arg Pro Arg Gly Thr Ser Gly Met Gly Ala Arg 
            260                 265                 270


Val Ser Leu Gln Ala Leu Glu Ala Glu Ala Glu Ala Gly Ala Glu Thr 
        275                 280                 285


Glu Ala Met Leu Gln Arg His Ile Asp Arg Val Tyr Arg Asp Asp Thr 
    290                 295                 300


Phe Val Gly Arg Ser Thr Gly Thr Arg Ala Pro Pro Leu Thr Arg Pro 
305                 310                 315                 320


Met Ser Leu Ala Val Pro Gly Leu Thr Gly Gly Ala Gly Pro Ala Glu 
                325                 330                 335


Pro Leu Ser Pro Ala Met Ser Ile Ser Pro Gln Ala Thr Tyr Leu Ser 
            340                 345                 350


Lys Leu Ile Pro His Ala Val Leu Pro Pro Thr Val Asp Val Val Ala 
        355                 360                 365


Leu Gly Arg Cys Ser Leu Arg Thr Leu Ser Arg Cys Ser Leu His Ser 
    370                 375                 380


Ala Ser Pro Ala Ser Val Arg Ser Leu Gly Arg Phe Ser Ser Val Ser 
385                 390                 395                 400


Ser Pro Gln Pro Arg Ser Arg His Pro Ser Ser Ser Ser Asp Thr Trp 
                405                 410                 415


Ser His Ser Gln Ser Ser Asp Thr Ile Val Ser Asp Gly Ser Thr Leu 
            420                 425                 430


Ser Ser Lys Gly Gly Ser Glu Gly Gln Pro Glu Ser Ser Thr Ala Ser 
        435                 440                 445


Asn Ser Val Val Pro Pro Pro Gln Gly Gly Ser Gly Arg Gly Ser Pro 
    450                 455                 460


Ser Gly Gly Ser Thr Ala Glu Ala Ser Asp Thr Leu Ser Ile Arg Ser 
465                 470                 475                 480


Ser Gly Gln Leu Ser Gly Arg Ser Val Ser Leu Arg Lys Leu Lys Arg 
                485                 490                 495


Pro Pro Pro Pro Pro Arg Arg Thr His Ser Leu His Gln Arg Gly Leu 
            500                 505                 510


Ala Val Pro Asp Gly Pro Leu Gly Leu Pro Pro Lys Pro Glu Arg Lys 
        515                 520                 525


Gln Gln Pro Gln Leu Pro Arg Pro Pro Thr Thr Gly Gly Ser Glu Gly 
    530                 535                 540


Ala Gly Ala Ala Pro Cys Pro Pro Asn Pro Ala Asn Ser Trp Val Pro 
545                 550                 555                 560


Gly Leu Ser Pro Gly Gly Ser Arg Arg Pro Pro Arg Ser Pro Glu Arg 
                565                 570                 575


Thr Leu Ser Pro Ser Ser Gly Tyr Ser Ser Gln Ser Gly Thr Pro Thr 
            580                 585                 590


Leu Pro Pro Lys Gly 
        595


<210>  1722
<211>  1759
<212>  DNA
<213>  Homo sapiens

<400>  1722
ccgcggtgcc cgcccgcgag tctcgctgcc tccctcccgg ggctgcgggc ccggcggccg     60

ggctggctgg gccgcgcttg ggttcccgcg ccggctcccg cacccgcaat ggggaactca    120

caccacaaga ggaaggcccc cagcggtccc cgggtccgca gcttctggcg gttcgggcgg    180

tcggcgaagc ggccggcagg ctctgccaag gctgagaatg acaaacatct aagtgtaggg    240

cctggccagg ggccagggtc tgcagtggat gagcaccagg acaacgtctt ctttcccagt    300

gggcgacccc cccacctgga agagctgcac actcaggccc aggaggggct ccgctcccta    360

caacaccaag agaaacagaa actgaacaag ggtggctggg accatggaga cacccagagt    420

atccagtcct cccggacggg gccggatgaa gacaacatct ccttctgcag tcagaccaca    480

tcctacgtgg ctgagagctc cacagcagag gacgcgctct ccatccgctc ggagatgatc    540

cagcgcaaag gctccacctt ccgaccccat gactcatttc ccaaatctgg aaagtcaggg    600

cggcgtcggc gggagcggcg gagcactgtg ctgggactcc cgcagcatgt gcagaaggag    660

cttggcctga ggaatgagcg tgaggcacca ggcacgcccc gggctcctgg tgcacgggat    720

gccgtacgca tccccacagt ggacggccgc ccccgaggca cctcagggat gggggcccgg    780

gtgtccctgc aggcgctgga ggcggaggcg gaggctggcg ctgagacaga ggccatgctg    840

cagcgccaca ttgaccgtgt ctaccgggat gacacctttg ttggccggtc cacgggtacc    900

cgggccccac cattgacccg gcccatgtcc ctagcagtgc ctggattgac aggaggggca    960

gggcctgcag agcccctgag cccggccatg tccatctccc cccaggccac ctacctgtcg   1020

aagttgattc cacatgctgt gctgccgcct acagtggacg tggtggccct aggccgctgc   1080

agcctgcgca cactaagccg ctgcagcctg cactcggcca gcccagcctc agtccgctcg   1140

ctggggcgct tctcctccgt ctccagccca cagccccgca gccgccaccc atcctcctcc   1200

agtgacacct ggagccactc tcaatcctcc gacaccattg tgtctgacgg ttccaccctc   1260

tcctctaagg gtggctctga gggccagccg gagagctcta cggctagcaa tagcgtggta   1320

ccccctcccc agggaggcag tgggaggggc tctcccagtg ggggcagcac tgctgaggcc   1380

tcagacacac tcagcattcg gagcagtggg cagttgtctg gccggagtgt gtccctgcgt   1440

aagctgaagc ggcctccacc ccctccccgc cggacccact ccctccatca gcggggctta   1500

gcagtgcctg atgggccatt agggttgccc cctaagcctg agcgtaagca gcagccccag   1560

ctgcctcggc cacccaccac tggtggctca gaaggggcgg gggcagcacc ctgtccaccc   1620

aacccagcca acagctgggt acctggcttg tctccgggtg gttcccggcg ccccccacgg   1680

tccccagaac ggacactttc gccctccagt ggatactcga gccaaagtgg tactcccacc   1740

ctccctccca agggcctgg                                                1759


<210>  1723
<211>  549
<212>  PRT
<213>  Homo sapiens

<400>  1723

Met Gly Asn Ser His His Lys Arg Lys Ala Pro Ser Gly Pro Arg Val 
1               5                   10                  15


Arg Ser Phe Trp Arg Phe Gly Arg Ser Ala Lys Arg Pro Ala Gly Ser 
            20                  25                  30


Ala Lys Ala Glu Asn Asp Lys His Leu Ser Val Gly Pro Gly Gln Gly 
        35                  40                  45


Pro Gly Ser Ala Val Asp Glu His Gln Asp Asn Val Phe Phe Pro Ser 
    50                  55                  60


Gly Arg Pro Pro His Leu Glu Glu Leu His Thr Gln Ala Gln Glu Gly 
65                  70                  75                  80


Leu Arg Ser Leu Gln His Gln Glu Lys Gln Lys Leu Asn Lys Gly Gly 
                85                  90                  95


Trp Asp His Gly Asp Thr Gln Ser Ile Gln Ser Ser Arg Thr Gly Pro 
            100                 105                 110


Asp Glu Asp Asn Ile Ser Phe Cys Ser Gln Thr Thr Ser Tyr Val Ala 
        115                 120                 125


Glu Ser Ser Thr Ala Glu Asp Ala Leu Ser Ile Arg Ser Glu Met Ile 
    130                 135                 140


Gln Arg Lys Gly Ser Thr Phe Arg Pro His Asp Ser Phe Pro Lys Ser 
145                 150                 155                 160


Gly Lys Ser Gly Arg Arg Arg Arg Glu Arg Arg Ser Thr Val Leu Gly 
                165                 170                 175


Leu Pro Gln His Val Gln Lys Glu Leu Gly Leu Arg Asn Glu Arg Glu 
            180                 185                 190


Ala Pro Gly Thr Pro Arg Ala Pro Gly Ala Arg Asp Ala Val Arg Ile 
        195                 200                 205


Pro Thr Val Asp Gly Arg Pro Arg Gly Thr Ser Gly Met Gly Ala Arg 
    210                 215                 220


Val Ser Leu Gln Ala Leu Glu Ala Glu Ala Glu Ala Gly Ala Glu Thr 
225                 230                 235                 240


Glu Ala Met Leu Gln Arg His Ile Asp Arg Val Tyr Arg Asp Asp Thr 
                245                 250                 255


Phe Val Gly Arg Ser Thr Gly Thr Arg Ala Pro Pro Leu Thr Arg Pro 
            260                 265                 270


Met Ser Leu Ala Val Pro Gly Leu Thr Gly Gly Ala Gly Pro Ala Glu 
        275                 280                 285


Pro Leu Ser Pro Ala Met Ser Ile Ser Pro Gln Ala Thr Tyr Leu Ser 
    290                 295                 300


Lys Leu Ile Pro His Ala Val Leu Pro Pro Thr Val Asp Val Val Ala 
305                 310                 315                 320


Leu Gly Arg Cys Ser Leu Arg Thr Leu Ser Arg Cys Ser Leu His Ser 
                325                 330                 335


Ala Ser Pro Ala Ser Val Arg Ser Leu Gly Arg Phe Ser Ser Val Ser 
            340                 345                 350


Ser Pro Gln Pro Arg Ser Arg His Pro Ser Ser Ser Ser Asp Thr Trp 
        355                 360                 365


Ser His Ser Gln Ser Ser Asp Thr Ile Val Ser Asp Gly Ser Thr Leu 
    370                 375                 380


Ser Ser Lys Gly Gly Ser Glu Gly Gln Pro Glu Ser Ser Thr Ala Ser 
385                 390                 395                 400


Asn Ser Val Val Pro Pro Pro Gln Gly Gly Ser Gly Arg Gly Ser Pro 
                405                 410                 415


Ser Gly Gly Ser Thr Ala Glu Ala Ser Asp Thr Leu Ser Ile Arg Ser 
            420                 425                 430


Ser Gly Gln Leu Ser Gly Arg Ser Val Ser Leu Arg Lys Leu Lys Arg 
        435                 440                 445


Pro Pro Pro Pro Pro Arg Arg Thr His Ser Leu His Gln Arg Gly Leu 
    450                 455                 460


Ala Val Pro Asp Gly Pro Leu Gly Leu Pro Pro Lys Pro Glu Arg Lys 
465                 470                 475                 480


Gln Gln Pro Gln Leu Pro Arg Pro Pro Thr Thr Gly Gly Ser Glu Gly 
                485                 490                 495


Ala Gly Ala Ala Pro Cys Pro Pro Asn Pro Ala Asn Ser Trp Val Pro 
            500                 505                 510


Gly Leu Ser Pro Gly Gly Ser Arg Arg Pro Pro Arg Ser Pro Glu Arg 
        515                 520                 525


Thr Leu Ser Pro Ser Ser Gly Tyr Ser Ser Gln Ser Gly Thr Pro Thr 
    530                 535                 540


Leu Pro Pro Lys Gly 
545


<210>  1724
<211>  991
<212>  DNA
<213>  Homo sapiens

<400>  1724
cggggctgcg ggcccggcgg ccgggctggc tgggccgcgc ttgggttccc gcgccggctc     60

ccgcacccgc aatggggaac tcacaccaca agaggaaggc ccccagcggt ccccgggtcc    120

gcagcttctg gcggttcggg cggtcggcga agcggccggc aggctctgcc aaggctgaga    180

atgacaaaca tctaagtgta gggcctggcc aggggccagg gtctgcagtg gatgagcacc    240

aggacaacgt cttctttccc agtgggcgac ccccccacct ggaagagctg cacactcagg    300

cccaggaggg gctccgctcc ctacaacacc aagagaaaca gaaactgaac aagggtggct    360

gggaccatgg agacacccag agtatccagt cctcccggac ggggccggat gaagacaaca    420

tctccttctg cagtcagacc acatcctacg tggctgagag ctccacagca gaggacgcgc    480

tctccatccg ctcggagatg atccagcgca aaggtggatt catgggcagg ggagagggac    540

agtgggctcc attgggtccc agcatctgta gcttcttttc ctccttatcc agtgtttcac    600

caggctctct gattcaatga attcgggaaa cacagtaccc tgtgtcctct tgcacattcg    660

tgatacacac taactataaa gcagttaaga gttagaaaat cttggcggcc gggtgcggtg    720

gctcacgcct gtaatcccag cactttggga ggtcgaggtg ggcgggtcac gaggtcagga    780

gatcgagacc atcctggcta acacggtgaa tgaaaccccg tctctactaa aaatacaaaa    840

aattagcctt gcctgatggc gggtgcctgt agtcccagct acttgggagg ctgaggcagg    900

agaatggcgt gaacccagga ggtggagctt gcagtgagcc gagattgcac cactgcactc    960

cagcctggtc gacagtgtga gactccatct c                                   991


<210>  1725
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  1725

Met Gly Asn Ser His His Lys Arg Lys Ala Pro Ser Gly Pro Arg Val 
1               5                   10                  15


Arg Ser Phe Trp Arg Phe Gly Arg Ser Ala Lys Arg Pro Ala Gly Ser 
            20                  25                  30


Ala Lys Ala Glu Asn Asp Lys His Leu Ser Val Gly Pro Gly Gln Gly 
        35                  40                  45


Pro Gly Ser Ala Val Asp Glu His Gln Asp Asn Val Phe Phe Pro Ser 
    50                  55                  60


Gly Arg Pro Pro His Leu Glu Glu Leu His Thr Gln Ala Gln Glu Gly 
65                  70                  75                  80


Leu Arg Ser Leu Gln His Gln Glu Lys Gln Lys Leu Asn Lys Gly Gly 
                85                  90                  95


Trp Asp His Gly Asp Thr Gln Ser Ile Gln Ser Ser Arg Thr Gly Pro 
            100                 105                 110


Asp Glu Asp Asn Ile Ser Phe Cys Ser Gln Thr Thr Ser Tyr Val Ala 
        115                 120                 125


Glu Ser Ser Thr Ala Glu Asp Ala Leu Ser Ile Arg Ser Glu Met Ile 
    130                 135                 140


Gln Arg Lys Gly Gly Phe Met Gly Arg Gly Glu Gly Gln Trp Ala Pro 
145                 150                 155                 160


Leu Gly Pro Ser Ile Cys Ser Phe Phe Ser Ser Leu Ser Ser Val Ser 
                165                 170                 175


Pro Gly Ser Leu Ile Gln 
            180


<210>  1726
<211>  573
<212>  DNA
<213>  Homo sapiens

<400>  1726
gtctggagcc ggtgctctgc ggcggggcgg gagggctcgc atccccatag tgctgggtta     60

cagtgaaggt acgccccgcg ctctgctctg gagaggcagg gtgggatagg gaacgtctcg    120

agtggcgccc gcagtcatgg tggtgttcgt tggccgccgc ctcccggcgc tcctagggct    180

gtttaagaag aagggctctg ccaaggctga gaatgacaaa catctaagtg tagggcctgg    240

ccaggggcca gggtctgcag tggatgagca ccaggacaac gtcttctttc ccagtgggcg    300

acccccccac ctggaagagc tgcacactca ggcccaggag gggctccgct ccctacaaca    360

ccaagagaaa cagaaactga acaagggtgg ctgggaccat ggagacaccc agagtatcca    420

gtcctcccgg acggggccgg atgaagacaa catctccttc tgcagtcaga ccacatccta    480

cgtggctgag agctccacag cagaggacgc gctctccatc cgctcggaga tgatccagcg    540

caaagactca cagaaagagc tggcctgacc acc                                 573


<210>  1727
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  1727

Met Val Val Phe Val Gly Arg Arg Leu Pro Ala Leu Leu Gly Leu Phe 
1               5                   10                  15


Lys Lys Lys Gly Ser Ala Lys Ala Glu Asn Asp Lys His Leu Ser Val 
            20                  25                  30


Gly Pro Gly Gln Gly Pro Gly Ser Ala Val Asp Glu His Gln Asp Asn 
        35                  40                  45


Val Phe Phe Pro Ser Gly Arg Pro Pro His Leu Glu Glu Leu His Thr 
    50                  55                  60


Gln Ala Gln Glu Gly Leu Arg Ser Leu Gln His Gln Glu Lys Gln Lys 
65                  70                  75                  80


Leu Asn Lys Gly Gly Trp Asp His Gly Asp Thr Gln Ser Ile Gln Ser 
                85                  90                  95


Ser Arg Thr Gly Pro Asp Glu Asp Asn Ile Ser Phe Cys Ser Gln Thr 
            100                 105                 110


Thr Ser Tyr Val Ala Glu Ser Ser Thr Ala Glu Asp Ala Leu Ser Ile 
        115                 120                 125


Arg Ser Glu Met Ile Gln Arg Lys Asp Ser Gln Lys Glu Leu Ala 
    130                 135                 140


<210>  1728
<211>  5295
<212>  DNA
<213>  Homo sapiens

<400>  1728
ggctcgcatc cccatagtgc tgggttacag tgaaggtacg ccccgcgctc tgctctggag     60

aggcagggtg ggatagggaa cgtctcgagt ggcgcccgca gtcatggtgg tgttcgttgg    120

ccgccgcctc ccggcgctcc tagggctgtt taagaagaag ggctctgcca aggctgagaa    180

tgacaaacat ctaagtgtag ggcctggcca ggggccaggg tctgcagtgg atgagcacca    240

ggacaacgtc ttctttccca gtgggcgacc cccccacctg gaagagctgc acactcaggc    300

ccaggagggg ctccgctccc tacaacacca agagaaacag aaactgaaca agggtggctg    360

ggaccatgga gacacccaga gtatccagtc ctcccggacg gggccggatg aagacaacat    420

ctccttctgc agtcagacca catcctacgt ggctgagagc tccacagcag aggacgcgct    480

ctccatccgc tcggagatga tccagcgcaa aggctccacc ttccgacccc atgactcatt    540

tcccaaatct ggaaagtcag ggcggcgtcg gcgggagcgg cggagcactg tgctgggact    600

cccgcagcat gtgcagaagg agcttggcct gaggaatgag cgtgaggcac caggcacgcc    660

ccgggctcct ggtgcacggg atgccgtacg catccccaca gtggacggcc gcccccgagg    720

cacctcaggg atgggggccc gggtgtccct gcaggcgctg gaggcggagg cggaggctgg    780

cgctgagaca gaggccatgc tgcagcgcca cattgaccgt gtctaccggg atgacacctt    840

tgttggccgg tccacgggta cccgggcccc accattgacc cggcccatgt ccctagcagt    900

gcctggattg acaggagggg cagggcctgc agagcccctg agcccggcca tgtccatctc    960

cccccaggcc acctacctgt cgaagttgat tccacatgct gtgctgccgc ctacagtgga   1020

cgtggtggcc ctaggccgct gcagcctgcg cacactaagc cgctgcagcc tgcactcggc   1080

cagcccagcc tcagtccgct cgctggggcg cttctcctcc gtctccagcc cacagccccg   1140

cagccgccac ccatcctcct ccagtgacac ctggagccac tctcaatcct ccgacaccat   1200

tgtgtctgac ggttccaccc tctcctctaa gggtggctct gagggccagc cggagagctc   1260

tacggctagc aatagcgtgg taccccctcc ccagggaggc agtgggaggg gctctcccag   1320

tgggggcagc actgctgagg cctcagacac actcagcatt cggagcagtg ggcagttgtc   1380

tggccggagt gtgtccctgc gtaagctgaa gcggcctcca ccccctcccc gccggaccca   1440

ctccctccat cagcggggct tagcagtgcc tgatgggcca ttagggttgc cccctaagcc   1500

tgagcgtaag cagcagcccc agctgcctcg gccacccacc actggtggct cagaaggggc   1560

gggggcagca ccctgtccac ccaacccagc caacagctgg gtacctggct tgtctccggg   1620

tggttcccgg cgccccccac ggtccccaga acggacactt tcgccctcca gtggatactc   1680

gagccaaagt ggtactccca ccctccctcc caagggcctg gcaggtcccc ctgcttcccc   1740

aggcaaggcc cagcccccta aaccagagcg tgtcacgtct cttcgctccc ctggggcctc   1800

cgtctcctct tccctcacgt ctttatgttc ctcctcctct gacccagccc cctcagaccg   1860

ctctgggcca cagatattga cccccctggg tgacaggttt gtcatacctc ctcaccccaa   1920

ggtgcctgcc cccttctccc cacctccctc caagcccagg agccctaacc cagctgcccc   1980

tgctctagcc gcccctgctg tggttcctgg gcctgtttct accactgacg ccagtcctca   2040

gtcccctccc actccccaga caaccttgac tccactgcag gagtctcctg tcatctccaa   2100

agaccagtca cccccacctt ccccaccccc atcttatcat ccacccccac cacccactaa   2160

gaagccagag gtggttgtgg aggcaccatc tgcctcagag actgctgagg agcccctcca   2220

agatcccaac tggccccctc ccccaccccc tgcccctgag gagcaggacc tgtccatggc   2280

tgacttcccc ccaccagagg aggctttttt ctctgtggcc agccctgagc ctgcaggccc   2340

ttcaggctcc ccagagcttg tcagctcccc ggctgcttcg tcctcctcag ctactgcttt   2400

gcagattcag cccccgggta gcccagaccc tcctccagct ccgccagccc cagctcctgc   2460

tagttccgcc ccagggcatg tggccaagct ccctcagaag gaaccggtgg gctgtagcaa   2520

gggtggtggg cctcccaggg aggacgtagg tgcgcccctg gtcacgccct cgctcctgca   2580

gatggtgcgg ctgcgctccg tgggtgctcc aggaggggct cccaccccag cactggggcc   2640

atcggccccc cagaaaccac tgcgaagggc cctgtcaggg cgggccagcc cagtgcctgc   2700

cccctcctca gggctccatg ctgcggtccg actcaaggcc tgcagcctgg ccgccagtga   2760

aggcctctca agtgctcagc ccaacggacc gcctgaggca gagccacggc ctccccagtc   2820

ccctgcctca acggccagtt tcatcttctc caagggctct aggaagctgc agctggagcg   2880

gcccgtgtcc cctgagaccc aggctgacct ccagcggaat ctggtggcag aactccggag   2940

catctcagag cagcggccac cccaggcccc aaagaagtca cctaaggctc ccccacctgt   3000

ggcccgcaag ccgtctgtgg gagtcccccc acccgcctcc cccagttacc ctcgagctga   3060

gccccttact gctcctccca ccaatgggct ccctcacacc caggacagga ctaagaggga   3120

gctggcggag aatggaggtg tcctgcagct ggtgggccca gaggagaaga tgggcctccc   3180

gggctcagac tcacagaaag agctggcctg accaccaggc acctcactgg cactgctgac   3240

ccatcccaga aacacaatct cagggacccg agcagctcca aggacgagag gatacagcag   3300

acacaaccta atagagaggg cgcctgcagc cttaacctcc acggccttcg atacttatgc   3360

aagcctggtg ttgctcctgt cctcagagtc atcctgcgct catgcctttt cccgaatggg   3420

ttcacctctg gcagttgccg cttcagtctt ggccttagcc tcatcttgaa gtgggtagct   3480

ggcgggagag ggtggctgcg ccccctgctg gccctgaggc tgcagagttg ggagcaggac   3540

acctcacctg agtttcattt tttttcatgt ccaaaccatg cacatactat agtccagaat   3600

caaagcactt ttgaaaagtg gctgcatggc catcctccag ggcccaggaa gttgcattcc   3660

aagggcctgt ttacatggca gcagaatcca tccccggcag tcagcccata gcttgggacc   3720

agtctgtgcc ctcctgccca gtccagttta ctcctcttgg ttcctgaagg tggccaagtc   3780

attgtgttcc cacaggcttc tctaggctgg gggcaggtgt ggggctgtgg aattccaaag   3840

cacaaaaggt gcagagggga ttggccttcc tgtgcctcaa ctcaccaacc accctcctgc   3900

cttccagttc tgccaggtgc tccatgctgg ggacaagtag gagactgcca gggcccaaag   3960

aaatgggtga gcagtagagt catctcgggg cacttggcag tgtcaagcac ctgccccttg   4020

cctccttgac cacactgggg tgggtgggcc cccagcactt cagaggcagg agcctttggg   4080

ctgagcaagc actgaggagg tggatggaag ggagcatctg gaggggggga gcttccttga   4140

gcagtgggcc caggcctggc cctccacact tcattctctg acctttctct ctcctcattt   4200

cggtgcatgt cctttctgca gctgcctttc agcacaggtg gttccactgg gggcagctaa   4260

cgctgagtga caaggatggg aagccacagg tgcattttac tcaagtcttc tctagtcaat   4320

gaggggcacc cagtgcttct agggcaggct gggtggtggt cccctaggta tcagcctctc   4380

ttactgtact ctccgggaat gttaaccttt ctattttcag cctgtgccac ctgtctaggc   4440

aagctggctt ccccattggc ccctgtgggt ccacagcagc gtggctgccc cccagggcca   4500

ccgcttcttt cttgatcctc tttccttaac agtgacttgg gcttgagtct ggcaaggaac   4560

cttgctttta gcttcaccac caaggagaga ggttgacatg acctccccgc cccctcacca   4620

aggctgggaa cagaggggat gtggtgagag ccaggttcct ctggccctct ccagggtgtt   4680

ttccactagt cactactgtc ttctccttgt agctaatcaa tcaatattct tcccttgcct   4740

gtgggcagtg gagagtgctg ctgggtgtac gctgcacctg cccactgagt tggggaaaga   4800

ggataatcag tgagcactgt tctgctcaga gctcctgatc taccccaccc cctaggatcc   4860

aggactgggt caaagctgca tgaaaccagg ccctggcagc aacctgggaa tggctggagg   4920

tgggagagaa cctgacttct ctttccctct ccctcctcca acattactgg aactctatcc   4980

tgttaggatc ttctgagctt gtttccctgc tgggtgggac agaggacaaa ggagaaggga   5040

gggtctagaa gaggcagccc ttctttgtcc tctggggtaa atgagcttga cctagagtaa   5100

atggagagac caaaagcctc tgatttttaa tttccataaa atgttagaag tatatatata   5160

catatatata tttctttaaa tttttgagtc tttgatatgt ctaaaaatcc attccctctg   5220

ccctgaagcc tgagtgagac acatgaagaa aactgtgttt catttaaaga tgttaattaa   5280

atgattgaaa cttgg                                                    5295


<210>  1729
<211>  1035
<212>  PRT
<213>  Homo sapiens

<400>  1729

Met Val Val Phe Val Gly Arg Arg Leu Pro Ala Leu Leu Gly Leu Phe 
1               5                   10                  15


Lys Lys Lys Gly Ser Ala Lys Ala Glu Asn Asp Lys His Leu Ser Val 
            20                  25                  30


Gly Pro Gly Gln Gly Pro Gly Ser Ala Val Asp Glu His Gln Asp Asn 
        35                  40                  45


Val Phe Phe Pro Ser Gly Arg Pro Pro His Leu Glu Glu Leu His Thr 
    50                  55                  60


Gln Ala Gln Glu Gly Leu Arg Ser Leu Gln His Gln Glu Lys Gln Lys 
65                  70                  75                  80


Leu Asn Lys Gly Gly Trp Asp His Gly Asp Thr Gln Ser Ile Gln Ser 
                85                  90                  95


Ser Arg Thr Gly Pro Asp Glu Asp Asn Ile Ser Phe Cys Ser Gln Thr 
            100                 105                 110


Thr Ser Tyr Val Ala Glu Ser Ser Thr Ala Glu Asp Ala Leu Ser Ile 
        115                 120                 125


Arg Ser Glu Met Ile Gln Arg Lys Gly Ser Thr Phe Arg Pro His Asp 
    130                 135                 140


Ser Phe Pro Lys Ser Gly Lys Ser Gly Arg Arg Arg Arg Glu Arg Arg 
145                 150                 155                 160


Ser Thr Val Leu Gly Leu Pro Gln His Val Gln Lys Glu Leu Gly Leu 
                165                 170                 175


Arg Asn Glu Arg Glu Ala Pro Gly Thr Pro Arg Ala Pro Gly Ala Arg 
            180                 185                 190


Asp Ala Val Arg Ile Pro Thr Val Asp Gly Arg Pro Arg Gly Thr Ser 
        195                 200                 205


Gly Met Gly Ala Arg Val Ser Leu Gln Ala Leu Glu Ala Glu Ala Glu 
    210                 215                 220


Ala Gly Ala Glu Thr Glu Ala Met Leu Gln Arg His Ile Asp Arg Val 
225                 230                 235                 240


Tyr Arg Asp Asp Thr Phe Val Gly Arg Ser Thr Gly Thr Arg Ala Pro 
                245                 250                 255


Pro Leu Thr Arg Pro Met Ser Leu Ala Val Pro Gly Leu Thr Gly Gly 
            260                 265                 270


Ala Gly Pro Ala Glu Pro Leu Ser Pro Ala Met Ser Ile Ser Pro Gln 
        275                 280                 285


Ala Thr Tyr Leu Ser Lys Leu Ile Pro His Ala Val Leu Pro Pro Thr 
    290                 295                 300


Val Asp Val Val Ala Leu Gly Arg Cys Ser Leu Arg Thr Leu Ser Arg 
305                 310                 315                 320


Cys Ser Leu His Ser Ala Ser Pro Ala Ser Val Arg Ser Leu Gly Arg 
                325                 330                 335


Phe Ser Ser Val Ser Ser Pro Gln Pro Arg Ser Arg His Pro Ser Ser 
            340                 345                 350


Ser Ser Asp Thr Trp Ser His Ser Gln Ser Ser Asp Thr Ile Val Ser 
        355                 360                 365


Asp Gly Ser Thr Leu Ser Ser Lys Gly Gly Ser Glu Gly Gln Pro Glu 
    370                 375                 380


Ser Ser Thr Ala Ser Asn Ser Val Val Pro Pro Pro Gln Gly Gly Ser 
385                 390                 395                 400


Gly Arg Gly Ser Pro Ser Gly Gly Ser Thr Ala Glu Ala Ser Asp Thr 
                405                 410                 415


Leu Ser Ile Arg Ser Ser Gly Gln Leu Ser Gly Arg Ser Val Ser Leu 
            420                 425                 430


Arg Lys Leu Lys Arg Pro Pro Pro Pro Pro Arg Arg Thr His Ser Leu 
        435                 440                 445


His Gln Arg Gly Leu Ala Val Pro Asp Gly Pro Leu Gly Leu Pro Pro 
    450                 455                 460


Lys Pro Glu Arg Lys Gln Gln Pro Gln Leu Pro Arg Pro Pro Thr Thr 
465                 470                 475                 480


Gly Gly Ser Glu Gly Ala Gly Ala Ala Pro Cys Pro Pro Asn Pro Ala 
                485                 490                 495


Asn Ser Trp Val Pro Gly Leu Ser Pro Gly Gly Ser Arg Arg Pro Pro 
            500                 505                 510


Arg Ser Pro Glu Arg Thr Leu Ser Pro Ser Ser Gly Tyr Ser Ser Gln 
        515                 520                 525


Ser Gly Thr Pro Thr Leu Pro Pro Lys Gly Leu Ala Gly Pro Pro Ala 
    530                 535                 540


Ser Pro Gly Lys Ala Gln Pro Pro Lys Pro Glu Arg Val Thr Ser Leu 
545                 550                 555                 560


Arg Ser Pro Gly Ala Ser Val Ser Ser Ser Leu Thr Ser Leu Cys Ser 
                565                 570                 575


Ser Ser Ser Asp Pro Ala Pro Ser Asp Arg Ser Gly Pro Gln Ile Leu 
            580                 585                 590


Thr Pro Leu Gly Asp Arg Phe Val Ile Pro Pro His Pro Lys Val Pro 
        595                 600                 605


Ala Pro Phe Ser Pro Pro Pro Ser Lys Pro Arg Ser Pro Asn Pro Ala 
    610                 615                 620


Ala Pro Ala Leu Ala Ala Pro Ala Val Val Pro Gly Pro Val Ser Thr 
625                 630                 635                 640


Thr Asp Ala Ser Pro Gln Ser Pro Pro Thr Pro Gln Thr Thr Leu Thr 
                645                 650                 655


Pro Leu Gln Glu Ser Pro Val Ile Ser Lys Asp Gln Ser Pro Pro Pro 
            660                 665                 670


Ser Pro Pro Pro Ser Tyr His Pro Pro Pro Pro Pro Thr Lys Lys Pro 
        675                 680                 685


Glu Val Val Val Glu Ala Pro Ser Ala Ser Glu Thr Ala Glu Glu Pro 
    690                 695                 700


Leu Gln Asp Pro Asn Trp Pro Pro Pro Pro Pro Pro Ala Pro Glu Glu 
705                 710                 715                 720


Gln Asp Leu Ser Met Ala Asp Phe Pro Pro Pro Glu Glu Ala Phe Phe 
                725                 730                 735


Ser Val Ala Ser Pro Glu Pro Ala Gly Pro Ser Gly Ser Pro Glu Leu 
            740                 745                 750


Val Ser Ser Pro Ala Ala Ser Ser Ser Ser Ala Thr Ala Leu Gln Ile 
        755                 760                 765


Gln Pro Pro Gly Ser Pro Asp Pro Pro Pro Ala Pro Pro Ala Pro Ala 
    770                 775                 780


Pro Ala Ser Ser Ala Pro Gly His Val Ala Lys Leu Pro Gln Lys Glu 
785                 790                 795                 800


Pro Val Gly Cys Ser Lys Gly Gly Gly Pro Pro Arg Glu Asp Val Gly 
                805                 810                 815


Ala Pro Leu Val Thr Pro Ser Leu Leu Gln Met Val Arg Leu Arg Ser 
            820                 825                 830


Val Gly Ala Pro Gly Gly Ala Pro Thr Pro Ala Leu Gly Pro Ser Ala 
        835                 840                 845


Pro Gln Lys Pro Leu Arg Arg Ala Leu Ser Gly Arg Ala Ser Pro Val 
    850                 855                 860


Pro Ala Pro Ser Ser Gly Leu His Ala Ala Val Arg Leu Lys Ala Cys 
865                 870                 875                 880


Ser Leu Ala Ala Ser Glu Gly Leu Ser Ser Ala Gln Pro Asn Gly Pro 
                885                 890                 895


Pro Glu Ala Glu Pro Arg Pro Pro Gln Ser Pro Ala Ser Thr Ala Ser 
            900                 905                 910


Phe Ile Phe Ser Lys Gly Ser Arg Lys Leu Gln Leu Glu Arg Pro Val 
        915                 920                 925


Ser Pro Glu Thr Gln Ala Asp Leu Gln Arg Asn Leu Val Ala Glu Leu 
    930                 935                 940


Arg Ser Ile Ser Glu Gln Arg Pro Pro Gln Ala Pro Lys Lys Ser Pro 
945                 950                 955                 960


Lys Ala Pro Pro Pro Val Ala Arg Lys Pro Ser Val Gly Val Pro Pro 
                965                 970                 975


Pro Ala Ser Pro Ser Tyr Pro Arg Ala Glu Pro Leu Thr Ala Pro Pro 
            980                 985                 990


Thr Asn Gly Leu Pro His Thr Gln Asp Arg Thr Lys Arg Glu Leu Ala 
        995                 1000                1005


Glu Asn Gly Gly Val Leu Gln Leu Val Gly Pro Glu Glu Lys Met Gly 
    1010                1015                1020


Leu Pro Gly Ser Asp Ser Gln Lys Glu Leu Ala 
1025                1030                1035


<210>  1730
<211>  2912
<212>  DNA
<213>  Homo sapiens

<400>  1730
ctgacttcaa aatttctgag gagtgcatcg cacagtggaa gcaaaccaac ttcatgacca     60

agctgggctc catttcctgt aaatcgctga aaggggggaa cattagctag ccagcccagc    120

atcttccccc cttcttccac cactgagtca tctgctgtct cttcaaactc ggcaaggggc    180

agcttaccct ccccagaacc caggatcatc ctgtctggct gcagtgagag accaacccct    240

aacaagggct gggccacagc agggagtcca gccctacctt cttcccttgg cagctggaga    300

aatctggttt caatataact catttaaaaa tttatgccac agtccttata attggaaaaa    360

tactggtgcc caggttttct tggagttatc caagcagctg cgcccctagc tgggatctgg    420

tacctggact aggctaatta cagcttctcc ccaacaggaa actgtgggat ttgaaaagga    480

aagggaaggg aaaacagaga acctagtggt ctaccaagtg gttggcaact ttcccaatgt    540

ctgcttactc tgaggcttgg cactgggggc cagggcctgc cccagggctc ctggaatttc    600

ccttgatcca gctaggctgg gacactccct aaatcagctg cgtgttgtta gcatcaggca    660

gaatgaatgg cagagagtga ttctgtcttc atagagggtg gggtacttct ccataaggca    720

tctcagtcaa atccccatca ctgtcataaa ttcaaataaa atgtctgaac aagggtgtct    780

ggatgtgagc tggaccatct caggagagaa cacaagtgtg aggcagctgc tggcccctca    840

cctagtctgg ggttccttta ccctgtaatg gggggtgggg ggtagaagat ggacaagaca    900

ccttaacagt ccctttggca gtactaggca gaagaggccc atacttgggt ccaatgtgtg    960

cagcaggcaa aacattttcc cttctaaatg tgggcccaga ccactgccct gtccccccca   1020

cattaagaag cagtagccac agccaagttt caatcattta attaacatct ttaaatgaaa   1080

cacagttttc ttcatgtgtc tcactcaggc ttcagggcag agggaatgga tttttagaca   1140

tatcaaagac tcaaaaattt aaagaaatat atatatgtat atatatactt ctaacatttt   1200

atggaaatta aaaatcagag gcttttggtc tctccattta ctctaggtca agctcattta   1260

ccccagagga caaagaaggg ctgcctcttc tagaccctcc cttctccttt gtcctctgtc   1320

ccacccagca gggaaacaag ctcagaagat cctaacagga tagagttcca gtaatgttgg   1380

aggagggaga gggaaagaga agtcaggttc tctcccacct ccagccattc ccaggttgct   1440

gccagggcct ggtttcatgc agctttgacc cagtcctgga tcctaggggg tggggtagat   1500

caggagctct gagcagaaca gtgctcactg attatcctct ttccccaact cagtgggcag   1560

gtgcagcgta cacccagcag cactctccac tgcccacagg caagggaaga atattgattg   1620

attagctaca aggagaagac agtagtgact agtggaaaac accctggaga gggccagagg   1680

aacctggctc tcaccacatc ccctctgttc ccagccttgg tgagggggcg gggaggtcat   1740

gtcaacctct ctccttggtg gtgaagctaa aagcaaggtt ccttgccaga ctcaagccca   1800

agtcactgtt aaggaaagag gatcaagaaa gaagcggtgg ccctgggggg cagccacgct   1860

gctgtggacc cacaggggcc aatggggaag ccagcttgcc tagacaggtg gcacaggctg   1920

aaaatagaaa ggttaacatt cccggagagt acagtaagag aggctgatac ctaggggacc   1980

accacccagc ctgccctaga agcactgggt gcccctcatt gactagagaa gacttgagta   2040

aaatgcacct gtggcttccc atccttgtca ctcagcgtta gctgccccca gtggaaccac   2100

ctgtgctgaa aggcagctgc agaaaggaca tgcaccgaaa tgaggagaga gaaaggtcag   2160

agaatgaagt gtggagggcc aggcctgggc ccactgctca aggaagctcc ccccctccag   2220

atgctccctt ccatccacct cctcagtgct tgctcagccc aaaggctcct gcctctgaag   2280

tgctgggggc ccacccaccc cagtgtggtc aaggaggcaa ggggcaggtg cttgacactg   2340

ccaagtgccc cgagatgact ctactgctca cccatttctt tgggccctgg cagtctccta   2400

cttgtcccca gcatggagca cctggcagaa ctggaaggca ggagggtggt tggtgagttg   2460

aggcacagga aggccaatcc cctctgcacc ttttgtgctt tggaattcca cagccccaca   2520

cctgccccca gcctagagaa gcctgtggga acacaatgac ttggccacct tcaggaacca   2580

agaggagtaa actggactgg gcaggagggc acagactggt cccaagctat gggctgactg   2640

ccggggatgg attctgctgc catgtaaaca ggcccttgga atgcaacttc ctgggccctg   2700

gaggatggcc atgcagccac ttttcaaaag tgctttgatt ctggactata gtatgtgcat   2760

ggtttggaca tgaaaaaaaa tgaaactcag gtgaggtgtc ctgctcccaa ctctgcagcc   2820

tcagggccag cagggggcgc agccaccctc tcccgccagc tacccacttc aagatgaggc   2880

taaggccaag actgaagcgg caactgccag ag                                 2912


<210>  1731
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  1731

Met His Arg Asn Glu Glu Arg Glu Arg Ser Glu Asn Glu Val Trp Arg 
1               5                   10                  15


Ala Arg Pro Gly Pro Thr Ala Gln Gly Ser Ser Pro Pro Pro Asp Ala 
            20                  25                  30


Pro Phe His Pro Pro Pro Gln Cys Leu Leu Ser Pro Lys Ala Pro Ala 
        35                  40                  45


Ser Glu Val Leu Gly Ala His Pro Pro Gln Cys Gly Gln Gly Gly Lys 
    50                  55                  60


Gly Gln Val Leu Asp Thr Ala Lys Cys Pro Glu Met Thr Leu Leu Leu 
65                  70                  75                  80


Thr His Phe Phe Gly Pro Trp Gln Ser Pro Thr Cys Pro Gln His Gly 
                85                  90                  95


Ala Pro Gly Arg Thr Gly Arg Gln Glu Gly Gly Trp 
            100                 105


<210>  1732
<211>  2781
<212>  DNA
<213>  Homo sapiens

<400>  1732
caggctgact tcaaaatttc tgaggagtgc atcgcacagt ggaagcaaac caacttcatg     60

accaagctgg gctccatttc ctgtaaatcg ctgaaagggg ggaacattag ctagccagcc    120

cagcatcttc cccccttctt ccaccactga gtcatctgct gtctcttcag tctgctccat    180

ccatcaccca tttacccatc tctcaggaca cggaagcagc gggtttggac tctttattcg    240

gtgcagaact cggcaagggg cagcttaccc tccccagaac ccaggatcat cctgtctggc    300

tgcagtgaga gaccaacccc taacaagggc tgggccacag cagggagtcc agccctacct    360

tcttcccttg gcagctggag aaatctggtt tcaatataac tcatttaaaa atttatgcca    420

cagtccttat aattggaaaa atactggtgc ccaggttttc ttggagttat ccaagcagct    480

ctaggctggg acactcccta aatcagctgc gtgttgttag catcaggcag aatgaatggc    540

agagagtgat tctgtcttca tagagggtgg ggtacttctc cataaggcat ctcagtcaaa    600

tccccatcac tgtcataaat tcaaataaaa tgtctgaaca agggtgtctg gatgtgagct    660

ggaccatctc aggagagaac acaagtgtga ggcagctgct ggcccctcac ctagtctggg    720

gttcctttac cctgtaatgg ggggtggggg gtagaagatg gacaagacac cttaacagtc    780

cctttggcag tactaggcag aagaggccca tacttgggtc caatgtgtgc agcaggcaaa    840

acattttccc ttctaaatgt gggcccagac cactgccctg tcccccccac attaagaagc    900

agtagccaca gccaagtttc aatcatttaa ttaacatctt taaatgaaac acagttttct    960

tcatgtgtct cactcaggct tcagggcaga gggaatggat ttttagacat atcaaagact   1020

caaaaattta aagaaatata tatatgtata tatatacttc taacatttta tggaaattaa   1080

aaatcagagg cttttggtct ctccatttac tctaggtcaa gctcatttac cccagaggac   1140

aaagaagggc tgcctcttct agaccctccc ttctcctttg tcctctgtcc cacccagcag   1200

ggaaacaagc tcagaagatc ctaacaggat agagttccag taatgttgga ggagggagag   1260

ggaaagagaa gtcaggttct ctcccacctc cagccattcc caggttgctg ccagggcctg   1320

gtttcatgca gctttgaccc agtcctggat cctagggggt ggggtagatc aggagctctg   1380

agcagaacag tgctcactga ttatcctctt tccccaactc agtgggcagg tgcagcgtac   1440

acccagcagc actctccact gcccacaggc aagggaagaa tattgattga ttagctacaa   1500

ggagaagaca gtagtgacta gtggaaaaca ccctggagag ggccagagga acctggctct   1560

caccacatcc cctctgttcc cagccttggt gagggggcgg ggaggtcatg tcaacctctc   1620

tccttggtgg tgaagctaaa agcaaggttc cttgccagac tcaagcccaa gtcactgtta   1680

aggaaagagg atcaagaaag aagcggtggc cctggggggc agccacgctg ctgtggaccc   1740

acaggggcca atggggaagc cagcttgcct agacaggtgg cacaggctga aaatagaaag   1800

gttaacattc ccggagagta cagtaagaga ggctgatacc taggggacca ccacccagcc   1860

tgccctagaa gcactgggtg cccctcattg actagagaag acttgagtaa aatgcacctg   1920

tggcttccca tccttgtcac tcagcgttag ctgcccccag tggaaccacc tgtgctgaaa   1980

ggcagctgca gaaaggacat gcaccgaaat gaggagagag aaaggtcaga gaatgaagtg   2040

tggagggcca ggcctgggcc cactgctcaa ggaagctccc cccctccaga tgctcccttc   2100

catccacctc ctcagtgctt gctcagccca aaggctcctg cctctgaagt gctgggggcc   2160

cacccacccc agtgtggtca aggaggcaag gggcaggtgc ttgacactgc caagtgcccc   2220

gagatgactc tactgctcac ccatttcttt gggccctggc agtctcctac ttgtccccag   2280

catggagcac ctggcagaac tggaaggcag gagggtggtt ggtgagttga ggcacaggaa   2340

ggccaatccc ctctgcacct tttgtgcttt ggaattccac agccccacac ctgcccccag   2400

cctagagaag cctgtgggaa cacaatgact tggccacctt caggaaccaa gaggagtaaa   2460

ctggactggg caggagggca cagactggtc ccaagctatg ggctgactgc cggggatgga   2520

ttctgctgcc atgtaaacag gcccttggaa tgcaacttcc tgggccctgg aggatggcca   2580

tgcagccact tttcaaaagt gctttgattc tggactatag tatgtgcatg gtttggacat   2640

gaaaaaaaat gaaactcagg tgaggtgtcc tgctcccaac tctgcagcct cagggccagc   2700

agggggcgca gccaccctct cccgccagct acccacttca agatgaggct aaggccaaga   2760

ctgaagcggc aactgccaga g                                             2781


<210>  1733
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  1733

Met His Arg Asn Glu Glu Arg Glu Arg Ser Glu Asn Glu Val Trp Arg 
1               5                   10                  15


Ala Arg Pro Gly Pro Thr Ala Gln Gly Ser Ser Pro Pro Pro Asp Ala 
            20                  25                  30


Pro Phe His Pro Pro Pro Gln Cys Leu Leu Ser Pro Lys Ala Pro Ala 
        35                  40                  45


Ser Glu Val Leu Gly Ala His Pro Pro Gln Cys Gly Gln Gly Gly Lys 
    50                  55                  60


Gly Gln Val Leu Asp Thr Ala Lys Cys Pro Glu Met Thr Leu Leu Leu 
65                  70                  75                  80


Thr His Phe Phe Gly Pro Trp Gln Ser Pro Thr Cys Pro Gln His Gly 
                85                  90                  95


Ala Pro Gly Arg Thr Gly Arg Gln Glu Gly Gly Trp 
            100                 105


<210>  1734
<211>  2638
<212>  DNA
<213>  Homo sapiens

<400>  1734
ccagatgcag acagcctgta tgtagagaag attgacgtgg gggaagctga accacggact     60

gtggtgagcg gcctggtaca gttcgtgccc aaggaggaac tgcaggacag gctggtagtg    120

cagctgcgcc cctagctggg atctggtacc tggactaggc taattacagc ttctccccaa    180

caggaaactg tgggatttga aaaggaaagg gaagggaaaa cagagaacct agtggtctac    240

caagtggttg gcaactttcc caatgtctgc ttactctgag gcttggcact gggggccagg    300

gcctgcccca gggctcctgg aatttccctt gatccagcta ggctgggaca ctccctaaat    360

cagctgcgtg ttgttagcat caggcagaat gaatggcaga gagtgattct gtcttcatag    420

agggtggggt acttctccat aaggcatctc agtcaaatcc ccatcactgt cataaattca    480

aataaaatgt ctgaacaagg gtgtctggat gtgagctgga ccatctcagg agagaacaca    540

agtgtgaggc agctgctggc ccctcaccta gtctggggtt cctttaccct gtaatggggg    600

gtggggggta gaagatggac aagacacctt aacagtccct ttggcagtac taggcagaag    660

aggcccatac ttgggtccaa tgtgtgcagc aggcaaaaca ttttcccttc taaatgtggg    720

cccagaccac tgccctgtcc cccccacatt aagaagcagt agccacagcc aagtttcaat    780

catttaatta acatctttaa atgaaacaca gttttcttca tgtgtctcac tcaggcttca    840

gggcagaggg aatggatttt tagacatatc aaagactcaa aaatttaaag aaatatatat    900

atgtatatat atacttctaa cattttatgg aaattaaaaa tcagaggctt ttggtctctc    960

catttactct aggtcaagct catttacccc agaggacaaa gaagggctgc ctcttctaga   1020

ccctcccttc tcctttgtcc tctgtcccac ccagcaggga aacaagctca gaagatccta   1080

acaggataga gttccagtaa tgttggagga gggagaggga aagagaagtc aggttctctc   1140

ccacctccag ccattcccag gttgctgcca gggcctggtt tcatgcagct ttgacccagt   1200

cctggatcct agggggtggg gtagatcagg agctctgagc agaacagtgc tcactgatta   1260

tcctctttcc ccaactcagt gggcaggtgc agcgtacacc cagcagcact ctccactgcc   1320

cacaggcaag ggaagaatat tgattgatta gctacaagga gaagacagta gtgactagtg   1380

gaaaacaccc tggagagggc cagaggaacc tggctctcac cacatcccct ctgttcccag   1440

ccttggtgag ggggcgggga ggtcatgtca acctctctcc ttggtggtga agctaaaagc   1500

aaggttcctt gccagactca agcccaagtc actgttaagg aaagaggatc aagaaagaag   1560

cggtggccct ggggggcagc cacgctgctg tggacccaca ggggccaatg gggaagccag   1620

cttgcctaga caggtggcac aggctgaaaa tagaaaggtt aacattcccg gagagtacag   1680

taagagaggc tgatacctag gggaccacca cccagcctgc cctagaagca ctgggtgccc   1740

ctcattgact agagaagact tgagtaaaat gcacctgtgg cttcccatcc ttgtcactca   1800

gcgttagctg cccccagtgg aaccacctgt gctgaaaggc agctgcagaa aggacatgca   1860

ccgaaatgag gagagagaaa ggtcagagaa tgaagtgtgg agggccaggc ctgggcccac   1920

tgctcaagga agctcccccc ctccagatgc tcccttccat ccacctcctc agtgcttgct   1980

cagcccaaag gctcctgcct ctgaagtgct gggggcccac ccaccccagt gtggtcaagg   2040

aggcaagggg caggtgcttg acactgccaa gtgccccgag atgactctac tgctcaccca   2100

tttctttggg ccctggcagt ctcctacttg tccccagcat ggagcacctg gcagaactgg   2160

aaggcaggag ggtggttggt gagttgaggc acaggaaggc caatcccctc tgcacctttt   2220

gtgctttgga attccacagc cccacacctg cccccagcct agagaagcct gtgggaacac   2280

aatgacttgg ccaccttcag gaaccaagag gagtaaactg gactgggcag gagggcacag   2340

actggtccca agctatgggc tgactgccgg ggatggattc tgctgccatg taaacaggcc   2400

cttggaatgc aacttcctgg gccctggagg atggccatgc agccactttt caaaagtgct   2460

ttgattctgg actatagtat gtgcatggtt tggacatgaa aaaaaatgaa actcaggtga   2520

ggtgtcctgc tcccaactct gcagcctcag ggccagcagg gggcgcagcc accctctccc   2580

gccagctacc cacttcaaga tgaggctaag gccaagactg aagcggcaac tgccagag     2638


<210>  1735
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  1735

Met His Arg Asn Glu Glu Arg Glu Arg Ser Glu Asn Glu Val Trp Arg 
1               5                   10                  15


Ala Arg Pro Gly Pro Thr Ala Gln Gly Ser Ser Pro Pro Pro Asp Ala 
            20                  25                  30


Pro Phe His Pro Pro Pro Gln Cys Leu Leu Ser Pro Lys Ala Pro Ala 
        35                  40                  45


Ser Glu Val Leu Gly Ala His Pro Pro Gln Cys Gly Gln Gly Gly Lys 
    50                  55                  60


Gly Gln Val Leu Asp Thr Ala Lys Cys Pro Glu Met Thr Leu Leu Leu 
65                  70                  75                  80


Thr His Phe Phe Gly Pro Trp Gln Ser Pro Thr Cys Pro Gln His Gly 
                85                  90                  95


Ala Pro Gly Arg Thr Gly Arg Gln Glu Gly Gly Trp 
            100                 105


<210>  1736
<211>  4320
<212>  DNA
<213>  Homo sapiens

<400>  1736
ttcagaaagt ggtggaggga agacttcctt tttcccagag acagaaggtt atgcacccag     60

tggcctggga ccattgttct gggctttttt tcccttcgac atggatttgc ttctcactgt    120

gtaccccaac caccaaaacc accctgagat caatgctggt gctcctgcat cagatggctt    180

agagatcctt ccacctctta acacaagcat ctaggtccac tttactcaaa tctggcctca    240

gttgagagca gagtatacca tcagagccca ttctcctgtc tgctgtctgg gacgtggaaa    300

gaaagttagc tctagggggt ctttccaggg gcctctgtaa ggagtggatg ctcctttccg    360

gaatccaaga gttcaccagg ctgcttctct aatggacgat gatcctcttc ctcctgacgt    420

ctctccctgg cagcacccag atgcagacag cctgtatgta gagaagattg acgtggggga    480

agctgaacca cggactgtgg tgagcggcct ggtacagttc gtgcccaagg aggaactgca    540

ggacaggctg gtagtggtgc tgtgcaacct gaaaccccag aagatgagag gagtcgagtc    600

ccaaggcatg cttctgtgtg cttctatgtg agtgaggact tggagtgggg cacaggacct    660

ggggaggcca ggaagagtag ggaatcagcc catatgatgt ccttccacac accaggtgga    720

agctctgaga acacgtgcct cttccttgct gatgccaaaa gttgatgcat gaaggactta    780

tcgtacaagt actgttaatg aagcatttta cctacagtta attttgttaa aatagaaatg    840

gagggctcaa accagtacat acccaagtct tactactagt aaggagtgga gcagggattc    900

aaatcccagt tttgatgtct ataaagtcct cgctacgtta ttttatactt cctcccctag    960

aaacacagat tttggtatct tgacacacaa ttttggtata gcctgggtta atgtaaccct   1020

ggtgatatgc agggatgtag caagataaga ggacctcctg gggctctggt actgaggatg   1080

ccctaaatcc catcagggcc cctgtgtaaa ggcccggatt gctttggcct ccacagtcac   1140

tggaacccat ccatagcctc actcttctct tgtcctgtgt cttcccagag aagggataaa   1200

ccgccaggtt gaacctctgg accctccggc aggctctgct cctggtgagc acgtgtttgt   1260

gaagggctat gaaaagggcc aaccagatga ggagctcaag cccaagaaga aagtcttcga   1320

gaagttgcag gctgacttca aaatttctga ggagtgcatc gcacagtgga agcaaaccaa   1380

cttcatgacc aagctgggct ccatttcctg taaatcgctg aaagggggga acattagcta   1440

gccagcccag catcttcccc ccttcttcca ccactgagtc atctgctgtc tcttcagtct   1500

gctccatcca tcacccattt acccatctct caggacacgg aagcagcggg tttggactct   1560

ttattcggtg cagaactcgg caaggggcag cttaccctcc ccagaaccca ggatcatcct   1620

gtctggctgc agtgagagac caacccctaa caagggctgg gccacagcag ggagtccagc   1680

cctaccttct tcccttggca gctggagaaa tctggtttca atataactca tttaaaaatt   1740

tatgccacag tccttataat tggaaaaata ctggtgccca ggttttcttg gagttatcca   1800

agcagctgcg cccctagctg ggatctggta cctggactag gctaattaca gcttctcccc   1860

aacaggaaac tgtgggattt gaaaaggaaa gggaagggaa aacagagaac ctagtggtct   1920

accaagtggt tggcaacttt cccaatgtct gcttactctg aggcttggca ctgggggcca   1980

gggcctgccc cagggctcct ggaatttccc ttgatccagc taggctggga cactccctaa   2040

atcagctgcg tgttgttagc atcaggcaga atgaatggca gagagtgatt ctgtcttcat   2100

agagggtggg gtacttctcc ataaggcatc tcagtcaaat ccccatcact gtcataaatt   2160

caaataaaat gtctgaacaa gggtgtctgg atgtgagctg gaccatctca ggagagaaca   2220

caagtgtgag gcagctgctg gcccctcacc tagtctgggg ttcctttacc ctgtaatggg   2280

gggtgggggg tagaagatgg acaagacacc ttaacagtcc ctttggcagt actaggcaga   2340

agaggcccat acttgggtcc aatgtgtgca gcaggcaaaa cattttccct tctaaatgtg   2400

ggcccagacc actgccctgt cccccccaca ttaagaagca gtagccacag ccaagtttca   2460

atcatttaat taacatcttt aaatgaaaca cagttttctt catgtgtctc actcaggctt   2520

cagggcagag ggaatggatt tttagacata tcaaagactc aaaaatttaa agaaatatat   2580

atatgtatat atatacttct aacattttat ggaaattaaa aatcagaggc ttttggtctc   2640

tccatttact ctaggtcaag ctcatttacc ccagaggaca aagaagggct gcctcttcta   2700

gaccctccct tctcctttgt cctctgtccc acccagcagg gaaacaagct cagaagatcc   2760

taacaggata gagttccagt aatgttggag gagggagagg gaaagagaag tcaggttctc   2820

tcccacctcc agccattccc aggttgctgc cagggcctgg tttcatgcag ctttgaccca   2880

gtcctggatc ctagggggtg gggtagatca ggagctctga gcagaacagt gctcactgat   2940

tatcctcttt ccccaactca gtgggcaggt gcagcgtaca cccagcagca ctctccactg   3000

cccacaggca agggaagaat attgattgat tagctacaag gagaagacag tagtgactag   3060

tggaaaacac cctggagagg gccagaggaa cctggctctc accacatccc ctctgttccc   3120

agccttggtg agggggcggg gaggtcatgt caacctctct ccttggtggt gaagctaaaa   3180

gcaaggttcc ttgccagact caagcccaag tcactgttaa ggaaagagga tcaagaaaga   3240

agcggtggcc ctggggggca gccacgctgc tgtggaccca caggggccaa tggggaagcc   3300

agcttgccta gacaggtggc acaggctgaa aatagaaagg ttaacattcc cggagagtac   3360

agtaagagag gctgatacct aggggaccac cacccagcct gccctagaag cactgggtgc   3420

ccctcattga ctagagaaga cttgagtaaa atgcacctgt ggcttcccat ccttgtcact   3480

cagcgttagc tgcccccagt ggaaccacct gtgctgaaag gcagctgcag aaaggacatg   3540

caccgaaatg aggagagaga aaggtcagag aatgaagtgt ggagggccag gcctgggccc   3600

actgctcaag gaagctcccc ccctccagat gctcccttcc atccacctcc tcagtgcttg   3660

ctcagcccaa aggctcctgc ctctgaagtg ctgggggccc acccacccca gtgtggtcaa   3720

ggaggcaagg ggcaggtgct tgacactgcc aagtgccccg agatgactct actgctcacc   3780

catttctttg ggccctggca gtctcctact tgtccccagc atggagcacc tggcagaact   3840

ggaaggcagg agggtggttg gtgagttgag gcacaggaag gccaatcccc tctgcacctt   3900

ttgtgctttg gaattccaca gccccacacc tgcccccagc ctagagaagc ctgtgggaac   3960

acaatgactt ggccaccttc aggaaccaag aggagtaaac tggactgggc aggagggcac   4020

agactggtcc caagctatgg gctgactgcc ggggatggat tctgctgcca tgtaaacagg   4080

cccttggaat gcaacttcct gggccctgga ggatggccat gcagccactt ttcaaaagtg   4140

ctttgattct ggactatagt atgtgcatgg tttggacatg aaaaaaaatg aaactcaggt   4200

gaggtgtcct gctcccaact ctgcagcctc agggccagca gggggcgcag ccaccctctc   4260

ccgccagcta cccacttcaa gatgaggcta aggccaagac tgaagcggca actgccagag   4320


<210>  1737
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  1737

Met Lys Arg Ala Asn Gln Met Arg Ser Ser Ser Pro Arg Arg Lys Ser 
1               5                   10                  15


Ser Arg Ser Cys Arg Leu Thr Ser Lys Phe Leu Arg Ser Ala Ser His 
            20                  25                  30


Ser Gly Ser Lys Pro Thr Ser 
        35


<210>  1738
<211>  4866
<212>  DNA
<213>  Homo sapiens

<400>  1738
aagaactgaa tttcagttta catttaaata cccacacaag gctagtagcc accatattgg     60

acagcagcag ccctagagct tttattaaaa ttaaatattc ccaaggaaat gaagaagtag    120

tatcagaaac aaaaatgttc gctttgttgt attaaaagtg ttcattccta agggatgtcc    180

cctcagaata tctagaagat tctttcagac cagatttgag atataaaaaa ggcagtcagc    240

tgggcgtggt ggctcacacc tgtaatccca gcactttggg aggctgaggc aggtggatca    300

cgaggtcagg agttcaagac cagtctgggc aacatggtga aaccccgtct ctactaaaat    360

acaaaaaatt agctgggcgt ggctgcatgc gcctgtagtc ccagctactc aggaggctga    420

ggcaggagaa ttgcttgagc tcaggaggca gaggttgcaa tgagctgaga ttgcgccact    480

gcaccccagc ctgggcgacg gagcaagact ccgtctcaaa gaaaaggcag tcacaggaca    540

caaggaataa aatggaatta ctgaactatt accatgtacg agcagcgttc tcatcatttt    600

cacacccaca ttcagtgatt taaccctcat ccccatcctg tgagatatag ctgttgttag    660

cttcacttta taagtaacaa agccaacact ggcccggcac gttggcccat gcctgtaatc    720

ctagcacttt gggaggcaga agcaggcaga ttgcctgaac ccaggagttc aagaccagcc    780

tgggtaacat agcaagaccc tgtctctaca aaaagaaaag agaaaaagca gcagccaaag    840

cttagagggg ttatgtgcct agtttggagt cgcacacagc tagctgggaa tctaatctgg    900

gtctgtcgaa ctccaaagcc cttcctcttt cttcttactc agctgtctcc ctcaggttat    960

ctttaggcct tgggttacct atgtgaatgt ttctctgctt gtaaatacca gttggtctgt   1020

gaccctactc taagcataaa tggagggact agaagaatta gactaacaaa tacattcagc   1080

tcctaaacac cctcaagtta gtatagattt cagaatcaaa agacttggat tttggacacg   1140

ttagtctttc tgaatgtatt ttcccttctc ctacctgcct cacaagatta tcacaaggat   1200

caaataagac tgttgggaaa aactcccttg atcctacttt tttggattca ggtgtcctgt   1260

gccctgttct agactttatc tcactaggtc ttgttcgatt ctgcaggttg tacatcctgg   1320

agacctgaag aattctgttg aagtcgcact gaacaagttg ctggatccaa tccgggaaaa   1380

gtttaatacc cctgccctga aaaaactggc cagcgctgcc tacccagatc cctcaaagca   1440

gaagccaatg gccaaaggcc ctgccaagaa ttcagaacca gaggaggtca tcccatcccg   1500

gctggatatc cgtgtgggga aaatcatcac tgtggagaag cacccagatg cagacagcct   1560

gtatgtagag aagattgacg tgggggaagc tgaaccacgg actgtggtga gcggcctggt   1620

acagttcgtg cccaaggagg aactgcagga caggctggta gtggtgctgt gcaacctgaa   1680

accccagaag atgagaggag tcgagtccca aggcatgctt ctgtgtgctt ctatagaagg   1740

gataaaccgc caggttgaac ctctggaccc tccggcaggc tctgctcctg gtgagcacgt   1800

gtttgtgaag ggctatgaaa agggccaacc agatgaggag ctcaagccca agaagaaagt   1860

cttcgagaag ttgcaggctg acttcaaaat ttctgaggag tgcatcgcac agtggaagca   1920

aaccaacttc atgaccaagc tgggctccat ttcctgtaaa tcgctgaaag gggggaacat   1980

tagctagcca gcccagcatc ttcccccctt cttccaccac tgagtcatct gctgtctctt   2040

cagtctgctc catccatcac ccatttaccc atctctcagg acacggaagc agcgggtttg   2100

gactctttat tcggtgcaga actcggcaag gggcagctta ccctccccag aacccaggat   2160

catcctgtct ggctgcagtg agagaccaac ccctaacaag ggctgggcca cagcagggag   2220

tccagcccta ccttcttccc ttggcagctg gagaaatctg gtttcaatat aactcattta   2280

aaaatttatg ccacagtcct tataattgga aaaatactgg tgcccaggtt ttcttggagt   2340

tatccaagca gctgcgcccc tagctgggat ctggtacctg gactaggcta attacagctt   2400

ctccccaaca ggaaactgtg ggatttgaaa aggaaaggga agggaaaaca gagaacctag   2460

tggtctacca agtggttggc aactttccca atgtctgctt actctgaggc ttggcactgg   2520

gggccagggc ctgccccagg gctcctggaa tttcccttga tccagctagg ctgggacact   2580

ccctaaatca gctgcgtgtt gttagcatca ggcagaatga atggcagaga gtgattctgt   2640

cttcatagag ggtggggtac ttctccataa ggcatctcag tcaaatcccc atcactgtca   2700

taaattcaaa taaaatgtct gaacaagggt gtctggatgt gagctggacc atctcaggag   2760

agaacacaag tgtgaggcag ctgctggccc ctcacctagt ctggggttcc tttaccctgt   2820

aatggggggt ggggggtaga agatggacaa gacaccttaa cagtcccttt ggcagtacta   2880

ggcagaagag gcccatactt gggtccaatg tgtgcagcag gcaaaacatt ttcccttcta   2940

aatgtgggcc cagaccactg ccctgtcccc cccacattaa gaagcagtag ccacagccaa   3000

gtttcaatca tttaattaac atctttaaat gaaacacagt tttcttcatg tgtctcactc   3060

aggcttcagg gcagagggaa tggattttta gacatatcaa agactcaaaa atttaaagaa   3120

atatatatat gtatatatat acttctaaca ttttatggaa attaaaaatc agaggctttt   3180

ggtctctcca tttactctag gtcaagctca tttaccccag aggacaaaga agggctgcct   3240

cttctagacc ctcccttctc ctttgtcctc tgtcccaccc agcagggaaa caagctcaga   3300

agatcctaac aggatagagt tccagtaatg ttggaggagg gagagggaaa gagaagtcag   3360

gttctctccc acctccagcc attcccaggt tgctgccagg gcctggtttc atgcagcttt   3420

gacccagtcc tggatcctag ggggtggggt agatcaggag ctctgagcag aacagtgctc   3480

actgattatc ctctttcccc aactcagtgg gcaggtgcag cgtacaccca gcagcactct   3540

ccactgccca caggcaaggg aagaatattg attgattagc tacaaggaga agacagtagt   3600

gactagtgga aaacaccctg gagagggcca gaggaacctg gctctcacca catcccctct   3660

gttcccagcc ttggtgaggg ggcggggagg tcatgtcaac ctctctcctt ggtggtgaag   3720

ctaaaagcaa ggttccttgc cagactcaag cccaagtcac tgttaaggaa agaggatcaa   3780

gaaagaagcg gtggccctgg ggggcagcca cgctgctgtg gacccacagg ggccaatggg   3840

gaagccagct tgcctagaca ggtggcacag gctgaaaata gaaaggttaa cattcccgga   3900

gagtacagta agagaggctg atacctaggg gaccaccacc cagcctgccc tagaagcact   3960

gggtgcccct cattgactag agaagacttg agtaaaatgc acctgtggct tcccatcctt   4020

gtcactcagc gttagctgcc cccagtggaa ccacctgtgc tgaaaggcag ctgcagaaag   4080

gacatgcacc gaaatgagga gagagaaagg tcagagaatg aagtgtggag ggccaggcct   4140

gggcccactg ctcaaggaag ctccccccct ccagatgctc ccttccatcc acctcctcag   4200

tgcttgctca gcccaaaggc tcctgcctct gaagtgctgg gggcccaccc accccagtgt   4260

ggtcaaggag gcaaggggca ggtgcttgac actgccaagt gccccgagat gactctactg   4320

ctcacccatt tctttgggcc ctggcagtct cctacttgtc cccagcatgg agcacctggc   4380

agaactggaa ggcaggaggg tggttggtga gttgaggcac aggaaggcca atcccctctg   4440

caccttttgt gctttggaat tccacagccc cacacctgcc cccagcctag agaagcctgt   4500

gggaacacaa tgacttggcc accttcagga accaagagga gtaaactgga ctgggcagga   4560

gggcacagac tggtcccaag ctatgggctg actgccgggg atggattctg ctgccatgta   4620

aacaggccct tggaatgcaa cttcctgggc cctggaggat ggccatgcag ccacttttca   4680

aaagtgcttt gattctggac tatagtatgt gcatggtttg gacatgaaaa aaaatgaaac   4740

tcaggtgagg tgtcctgctc ccaactctgc agcctcaggg ccagcagggg gcgcagccac   4800

cctctcccgc cagctaccca cttcaagatg aggctaaggc caagactgaa gcggcaactg   4860

ccagag                                                              4866


<210>  1739
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  1739

Met Ala Lys Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro 
1               5                   10                  15


Ser Arg Leu Asp Ile Arg Val Gly Lys Ile Ile Thr Val Glu Lys His 
            20                  25                  30


Pro Asp Ala Asp Ser Leu Tyr Val Glu Lys Ile Asp Val Gly Glu Ala 
        35                  40                  45


Glu Pro Arg Thr Val Val Ser Gly Leu Val Gln Phe Val Pro Lys Glu 
    50                  55                  60


Glu Leu Gln Asp Arg Leu Val Val Val Leu Cys Asn Leu Lys Pro Gln 
65                  70                  75                  80


Lys Met Arg Gly Val Glu Ser Gln Gly Met Leu Leu Cys Ala Ser Ile 
                85                  90                  95


Glu Gly Ile Asn Arg Gln Val Glu Pro Leu Asp Pro Pro Ala Gly Ser 
            100                 105                 110


Ala Pro Gly Glu His Val Phe Val Lys Gly Tyr Glu Lys Gly Gln Pro 
        115                 120                 125


Asp Glu Glu Leu Lys Pro Lys Lys Lys Val Phe Glu Lys Leu Gln Ala 
    130                 135                 140


Asp Phe Lys Ile Ser Glu Glu Cys Ile Ala Gln Trp Lys Gln Thr Asn 
145                 150                 155                 160


Phe Met Thr Lys Leu Gly Ser Ile Ser Cys Lys Ser Leu Lys Gly Gly 
                165                 170                 175


Asn Ile Ser 



<210>  1740
<211>  4191
<212>  DNA
<213>  Homo sapiens

<400>  1740
gaacaatggg gttctgtcct tcatcaagca tgtccttttt ccccttaagt ccggtaacac     60

tctctgtttt cttcctagag gccaggctag aatagaaaag ttcgtgctgt gatcatactt    120

gtgatttgtc acagactctt ccttcaggga ctggctgccc tgattctctg ctctgatttc    180

ttatatatta aagtatgaat gatgttggga tgtaatttaa ttgtccatat attcgttacc    240

aggctaggtt ctgagggaat actggagtgg gcagaggtgt tagaagtaag ggtgggggca    300

gacatgttga actagaggaa tacaacaaaa tagatataag ccacaagcct tcccctgaag    360

cagctgagat gctagctggg tatacaatag tgccactcat ccaatttaag aataatacca    420

tacaataaag ttcagaatat atggcaaaaa ctacaaatag tcatgcatgt gggctaggaa    480

tagtcatgca tgtgagctag gaatgctgtc aatgagtttg ttgacatgga tccttttcct    540

tatagagttt gtgatcctac gagatgagaa atggggtgga aacaaaacct acacagctta    600

cgtggacctg gaaaaggact ttgctgctga ggttgtacat cctggagacc tgaagaattc    660

tgttgaagtc gcactgaaca agttgctgga tccaatccgg gaaaagttta atacccctgc    720

cctgaaaaaa ctggccagcg ctgcctaccc agatccctca aagcagaagc caatggccaa    780

aggccctgcc aagaattcag aaccagagga ggtcatccca tcccggctgg atatccgtgt    840

ggggaaaatc atcactgtgg agaagcaccc agatgcagac agcctgtatg tagagaagat    900

tgacgtgggg gaagctgaac cacggactgt ggtgagcggc ctggtacagt tcgtgcccaa    960

ggaggaactg caggacaggc tggtagtggt gctgtgcaac ctgaaacccc agaagatgag   1020

aggagtcgag tcccaaggca tgcttctgtg tgcttctata gaagggataa accgccaggt   1080

tgaacctctg gaccctccgg caggctctgc tcctggtgag cacgtgtttg tgaagggcta   1140

tgaaaagggc caaccagatg aggagctcaa gcccaagaag aaagtcttcg agaagttgca   1200

ggctgacttc aaaatttctg aggagtgcat cgcacagtgg aagcaaacca acttcatgac   1260

caagctgggc tccatttcct gtaaatcgct gaaagggggg aacattagct agccagccca   1320

gcatcttccc cccttcttcc accactgagt catctgctgt ctcttcagtc tgctccatcc   1380

atcacccatt tacccatctc tcaggacacg gaagcagcgg gtttggactc tttattcggt   1440

gcagaactcg gcaaggggca gcttaccctc cccagaaccc aggatcatcc tgtctggctg   1500

cagtgagaga ccaaccccta acaagggctg ggccacagca gggagtccag ccctaccttc   1560

ttcccttggc agctggagaa atctggtttc aatataactc atttaaaaat ttatgccaca   1620

gtccttataa ttggaaaaat actggtgccc aggttttctt ggagttatcc aagcagctgc   1680

gcccctagct gggatctggt acctggacta ggctaattac agcttctccc caacaggaaa   1740

ctgtgggatt tgaaaaggaa agggaaggga aaacagagaa cctagtggtc taccaagtgg   1800

ttggcaactt tcccaatgtc tgcttactct gaggcttggc actgggggcc agggcctgcc   1860

ccagggctcc tggaatttcc cttgatccag ctaggctggg acactcccta aatcagctgc   1920

gtgttgttag catcaggcag aatgaatggc agagagtgat tctgtcttca tagagggtgg   1980

ggtacttctc cataaggcat ctcagtcaaa tccccatcac tgtcataaat tcaaataaaa   2040

tgtctgaaca agggtgtctg gatgtgagct ggaccatctc aggagagaac acaagtgtga   2100

ggcagctgct ggcccctcac ctagtctggg gttcctttac cctgtaatgg ggggtggggg   2160

gtagaagatg gacaagacac cttaacagtc cctttggcag tactaggcag aagaggccca   2220

tacttgggtc caatgtgtgc agcaggcaaa acattttccc ttctaaatgt gggcccagac   2280

cactgccctg tcccccccac attaagaagc agtagccaca gccaagtttc aatcatttaa   2340

ttaacatctt taaatgaaac acagttttct tcatgtgtct cactcaggct tcagggcaga   2400

gggaatggat ttttagacat atcaaagact caaaaattta aagaaatata tatatgtata   2460

tatatacttc taacatttta tggaaattaa aaatcagagg cttttggtct ctccatttac   2520

tctaggtcaa gctcatttac cccagaggac aaagaagggc tgcctcttct agaccctccc   2580

ttctcctttg tcctctgtcc cacccagcag ggaaacaagc tcagaagatc ctaacaggat   2640

agagttccag taatgttgga ggagggagag ggaaagagaa gtcaggttct ctcccacctc   2700

cagccattcc caggttgctg ccagggcctg gtttcatgca gctttgaccc agtcctggat   2760

cctagggggt ggggtagatc aggagctctg agcagaacag tgctcactga ttatcctctt   2820

tccccaactc agtgggcagg tgcagcgtac acccagcagc actctccact gcccacaggc   2880

aagggaagaa tattgattga ttagctacaa ggagaagaca gtagtgacta gtggaaaaca   2940

ccctggagag ggccagagga acctggctct caccacatcc cctctgttcc cagccttggt   3000

gagggggcgg ggaggtcatg tcaacctctc tccttggtgg tgaagctaaa agcaaggttc   3060

cttgccagac tcaagcccaa gtcactgtta aggaaagagg atcaagaaag aagcggtggc   3120

cctggggggc agccacgctg ctgtggaccc acaggggcca atggggaagc cagcttgcct   3180

agacaggtgg cacaggctga aaatagaaag gttaacattc ccggagagta cagtaagaga   3240

ggctgatacc taggggacca ccacccagcc tgccctagaa gcactgggtg cccctcattg   3300

actagagaag acttgagtaa aatgcacctg tggcttccca tccttgtcac tcagcgttag   3360

ctgcccccag tggaaccacc tgtgctgaaa ggcagctgca gaaaggacat gcaccgaaat   3420

gaggagagag aaaggtcaga gaatgaagtg tggagggcca ggcctgggcc cactgctcaa   3480

ggaagctccc cccctccaga tgctcccttc catccacctc ctcagtgctt gctcagccca   3540

aaggctcctg cctctgaagt gctgggggcc cacccacccc agtgtggtca aggaggcaag   3600

gggcaggtgc ttgacactgc caagtgcccc gagatgactc tactgctcac ccatttcttt   3660

gggccctggc agtctcctac ttgtccccag catggagcac ctggcagaac tggaaggcag   3720

gagggtggtt ggtgagttga ggcacaggaa ggccaatccc ctctgcacct tttgtgcttt   3780

ggaattccac agccccacac ctgcccccag cctagagaag cctgtgggaa cacaatgact   3840

tggccacctt caggaaccaa gaggagtaaa ctggactggg caggagggca cagactggtc   3900

ccaagctatg ggctgactgc cggggatgga ttctgctgcc atgtaaacag gcccttggaa   3960

tgcaacttcc tgggccctgg aggatggcca tgcagccact tttcaaaagt gctttgattc   4020

tggactatag tatgtgcatg gtttggacat gaaaaaaaat gaaactcagg tgaggtgtcc   4080

tgctcccaac tctgcagcct cagggccagc agggggcgca gccaccctct cccgccagct   4140

acccacttca agatgaggct aaggccaaga ctgaagcggc aactgccaga g            4191


<210>  1741
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  1741

Met Trp Ala Arg Asn Ser His Ala Cys Glu Leu Gly Met Leu Ser Met 
1               5                   10                  15


Ser Leu Leu Thr Trp Ile Leu Phe Leu Ile Glu Phe Val Ile Leu Arg 
            20                  25                  30


Asp Glu Lys Trp Gly Gly Asn Lys Thr Tyr Thr Ala Tyr Val Asp Leu 
        35                  40                  45


Glu Lys Asp Phe Ala Ala Glu Val Val His Pro Gly Asp Leu Lys Asn 
    50                  55                  60


Ser Val Glu Val Ala Leu Asn Lys Leu Leu Asp Pro Ile Arg Glu Lys 
65                  70                  75                  80


Phe Asn Thr Pro Ala Leu Lys Lys Leu Ala Ser Ala Ala Tyr Pro Asp 
                85                  90                  95


Pro Ser Lys Gln Lys Pro Met Ala Lys Gly Pro Ala Lys Asn Ser Glu 
            100                 105                 110


Pro Glu Glu Val Ile Pro Ser Arg Leu Asp Ile Arg Val Gly Lys Ile 
        115                 120                 125


Ile Thr Val Glu Lys His Pro Asp Ala Asp Ser Leu Tyr Val Glu Lys 
    130                 135                 140


Ile Asp Val Gly Glu Ala Glu Pro Arg Thr Val Val Ser Gly Leu Val 
145                 150                 155                 160


Gln Phe Val Pro Lys Glu Glu Leu Gln Asp Arg Leu Val Val Val Leu 
                165                 170                 175


Cys Asn Leu Lys Pro Gln Lys Met Arg Gly Val Glu Ser Gln Gly Met 
            180                 185                 190


Leu Leu Cys Ala Ser Ile Glu Gly Ile Asn Arg Gln Val Glu Pro Leu 
        195                 200                 205


Asp Pro Pro Ala Gly Ser Ala Pro Gly Glu His Val Phe Val Lys Gly 
    210                 215                 220


Tyr Glu Lys Gly Gln Pro Asp Glu Glu Leu Lys Pro Lys Lys Lys Val 
225                 230                 235                 240


Phe Glu Lys Leu Gln Ala Asp Phe Lys Ile Ser Glu Glu Cys Ile Ala 
                245                 250                 255


Gln Trp Lys Gln Thr Asn Phe Met Thr Lys Leu Gly Ser Ile Ser Cys 
            260                 265                 270


Lys Ser Leu Lys Gly Gly Asn Ile Ser 
        275                 280


<210>  1742
<211>  5395
<212>  DNA
<213>  Homo sapiens

<400>  1742
aaacccgccc ctcagcaggc ctgtgctgtg cgctcctctc ccggggacca ccgtcctcag     60

atctccccag ggaatgggtc gtcctcttcc tgcccccacc cgcgagacgc ggcagaaaag    120

cccgcggcta tcttcccgcc agcaacagcc tcccgccgag ccggccggga cagaggcggc    180

ccccaccccc actgggcagg ggactgcaga cggcgctccc cgactctcaa gacgaccagg    240

gagcttccct tttcctcagc ggggtgaggg gcatctgtcg cccgccgact tggaggtgga    300

ggggcaggga cattccctcg ccatcacctc aggagctaga acgcgccctt ctcgcagcag    360

ggcgtgggcc tcccaatccc tccaaggggc ggacggcgtg cgcaaccccc tggagaagca    420

acaggcgccc ccatccccct ccaagccggg taacgccgac cccctcgtcc ctcccgctct    480

tcacctccgg aagccgggcc aaagcctggg cgaacgactg cgcctcactc cgccccctgc    540

gccattttat cgccccctcc ccgacctccc ctaccccgag tcagccgggc caacaccagg    600

gggagggcaa accagcagtg attggcagga aaccgtcccg cctctaggag ggttgtgccc    660

cgctcaggcg cctcagcccc gccctccgca ccgcccaccg tgcccactgg ctccaccttt    720

tcccgtctca tcgacctgct cgactctctg ctgctcctca ctttttccgg ccgctgccgg    780

aggggtccag gccgagtaag cggagcgccg agcccagctg atgcaacctg gctggactcg    840

cgtgacagtt cccggcacgc ggcggcgacg gtgacccagg aaggggctct ggtgccgggc    900

tgagcggggg aagcaggggt agcggagcca tgggggacgc tcccagccct gaagagaaac    960

tgcaccttat cacccggaac ctgcaggagg ttctggggga agagaagctg aaggagatac   1020

tgaaggagcg ggaacttaaa atttactggg gaacggcaac cacgggcaaa ccacatgtgg   1080

cttactttgt gcccatgtca aagattgcag acttcttaaa ggcagggtgt gaggtaacaa   1140

ttctgtttgc ggacctccac gcatacctgg ataacatgaa agccccatgg gaacttctag   1200

aactccgagt cagttactat gagaatgtga tcaaagcaat gctggagagc attggtgtgc   1260

ccttggagaa gctcaagttc atcaaaggca ctgattacca gctcagcaaa gagtacacac   1320

tagatgtgta cagactctcc tccgtggtca cacagcacga ttccaagaag gctggagctg   1380

aggtggtaaa gcaggtggag caccctttgc tgagtggcct cttatacccc ggactgcagg   1440

ctttggatga agagtattta aaagtagatg cccaatttgg aggcattgat cagagaaaga   1500

ttttcacctt tgcagagaag tacctccctg cacttggcta ttcaaaacgg gtccatctga   1560

tgaatcctat ggttccagga ttaacaggca gcaaaatgag ctcttcagaa gaggagtcca   1620

agattgatct ccttgatcgg aaggaggatg tgaagaaaaa actgaagaag gccttctgtg   1680

agccaggaaa tgtggagaac aatggggttc tgtccttcat caagcatgtc ctttttcccc   1740

ttaagtccga gtttgtgatc ctacgagatg agaaatgggg tggaaacaaa acctacacag   1800

cttacgtgga cctggaaaag gactttgctg ctgaggttgt acatcctgga gacctgaaga   1860

attctgttga agtcgcactg aacaagttgc tggatccaat ccgggaaaag tttaataccc   1920

ctgccctgaa aaaactggcc agcgctgcct acccagatcc ctcaaagcag aagccaatgg   1980

ccaaaggccc tgccaagaat tcagaaccag aggaggtcat cccatcccgg ctggatatcc   2040

gtgtggggaa aatcatcact gtggagaagc acccagatgc agacagcctg tatgtagaga   2100

agattgacgt gggggaagct gaaccacgga ctgtggtgag cggcctggta cagttcgtgc   2160

ccaaggagga actgcaggac aggctggtag tggtgctgtg caacctgaaa ccccagaaga   2220

tgagaggagt cgagtcccaa ggcatgcttc tgtgtgcttc tatagaaggg ataaaccgcc   2280

aggttgaacc tctggaccct ccggcaggct ctgctcctgg tgagcacgtg tttgtgaagg   2340

gctatgaaaa gggccaacca gatgaggagc tcaagcccaa gaagaaagtc ttcgagaagt   2400

tgcaggctga cttcaaaatt tctgaggagt gcatcgcaca gtggaagcaa accaacttca   2460

tgaccaagct gggctccatt tcctgtaaat cgctgaaagg ggggaacatt agctagccag   2520

cccagcatct tccccccttc ttccaccact gagtcatctg ctgtctcttc agtctgctcc   2580

atccatcacc catttaccca tctctcagga cacggaagca gcgggtttgg actctttatt   2640

cggtgcagaa ctcggcaagg ggcagcttac cctccccaga acccaggatc atcctgtctg   2700

gctgcagtga gagaccaacc cctaacaagg gctgggccac agcagggagt ccagccctac   2760

cttcttccct tggcagctgg agaaatctgg tttcaatata actcatttaa aaatttatgc   2820

cacagtcctt ataattggaa aaatactggt gcccaggttt tcttggagtt atccaagcag   2880

ctgcgcccct agctgggatc tggtacctgg actaggctaa ttacagcttc tccccaacag   2940

gaaactgtgg gatttgaaaa ggaaagggaa gggaaaacag agaacctagt ggtctaccaa   3000

gtggttggca actttcccaa tgtctgctta ctctgaggct tggcactggg ggccagggcc   3060

tgccccaggg ctcctggaat ttcccttgat ccagctaggc tgggacactc cctaaatcag   3120

ctgcgtgttg ttagcatcag gcagaatgaa tggcagagag tgattctgtc ttcatagagg   3180

gtggggtact tctccataag gcatctcagt caaatcccca tcactgtcat aaattcaaat   3240

aaaatgtctg aacaagggtg tctggatgtg agctggacca tctcaggaga gaacacaagt   3300

gtgaggcagc tgctggcccc tcacctagtc tggggttcct ttaccctgta atggggggtg   3360

gggggtagaa gatggacaag acaccttaac agtccctttg gcagtactag gcagaagagg   3420

cccatacttg ggtccaatgt gtgcagcagg caaaacattt tcccttctaa atgtgggccc   3480

agaccactgc cctgtccccc ccacattaag aagcagtagc cacagccaag tttcaatcat   3540

ttaattaaca tctttaaatg aaacacagtt ttcttcatgt gtctcactca ggcttcaggg   3600

cagagggaat ggatttttag acatatcaaa gactcaaaaa tttaaagaaa tatatatatg   3660

tatatatata cttctaacat tttatggaaa ttaaaaatca gaggcttttg gtctctccat   3720

ttactctagg tcaagctcat ttaccccaga ggacaaagaa gggctgcctc ttctagaccc   3780

tcccttctcc tttgtcctct gtcccaccca gcagggaaac aagctcagaa gatcctaaca   3840

ggatagagtt ccagtaatgt tggaggaggg agagggaaag agaagtcagg ttctctccca   3900

cctccagcca ttcccaggtt gctgccaggg cctggtttca tgcagctttg acccagtcct   3960

ggatcctagg gggtggggta gatcaggagc tctgagcaga acagtgctca ctgattatcc   4020

tctttcccca actcagtggg caggtgcagc gtacacccag cagcactctc cactgcccac   4080

aggcaaggga agaatattga ttgattagct acaaggagaa gacagtagtg actagtggaa   4140

aacaccctgg agagggccag aggaacctgg ctctcaccac atcccctctg ttcccagcct   4200

tggtgagggg gcggggaggt catgtcaacc tctctccttg gtggtgaagc taaaagcaag   4260

gttccttgcc agactcaagc ccaagtcact gttaaggaaa gaggatcaag aaagaagcgg   4320

tggccctggg gggcagccac gctgctgtgg acccacaggg gccaatgggg aagccagctt   4380

gcctagacag gtggcacagg ctgaaaatag aaaggttaac attcccggag agtacagtaa   4440

gagaggctga tacctagggg accaccaccc agcctgccct agaagcactg ggtgcccctc   4500

attgactaga gaagacttga gtaaaatgca cctgtggctt cccatccttg tcactcagcg   4560

ttagctgccc ccagtggaac cacctgtgct gaaaggcagc tgcagaaagg acatgcaccg   4620

aaatgaggag agagaaaggt cagagaatga agtgtggagg gccaggcctg ggcccactgc   4680

tcaaggaagc tccccccctc cagatgctcc cttccatcca cctcctcagt gcttgctcag   4740

cccaaaggct cctgcctctg aagtgctggg ggcccaccca ccccagtgtg gtcaaggagg   4800

caaggggcag gtgcttgaca ctgccaagtg ccccgagatg actctactgc tcacccattt   4860

ctttgggccc tggcagtctc ctacttgtcc ccagcatgga gcacctggca gaactggaag   4920

gcaggagggt ggttggtgag ttgaggcaca ggaaggccaa tcccctctgc accttttgtg   4980

ctttggaatt ccacagcccc acacctgccc ccagcctaga gaagcctgtg ggaacacaat   5040

gacttggcca ccttcaggaa ccaagaggag taaactggac tgggcaggag ggcacagact   5100

ggtcccaagc tatgggctga ctgccgggga tggattctgc tgccatgtaa acaggccctt   5160

ggaatgcaac ttcctgggcc ctggaggatg gccatgcagc cacttttcaa aagtgctttg   5220

attctggact atagtatgtg catggtttgg acatgaaaaa aaatgaaact caggtgaggt   5280

gtcctgctcc caactctgca gcctcagggc cagcaggggg cgcagccacc ctctcccgcc   5340

agctacccac ttcaagatga ggctaaggcc aagactgaag cggcaactgc cagag        5395


<210>  1743
<211>  528
<212>  PRT
<213>  Homo sapiens

<400>  1743

Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg 
1               5                   10                  15


Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys 
            20                  25                  30


Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro 
        35                  40                  45


His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys 
    50                  55                  60


Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu 
65                  70                  75                  80


Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr 
                85                  90                  95


Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu 
            100                 105                 110


Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu 
        115                 120                 125


Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp 
    130                 135                 140


Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu 
145                 150                 155                 160


Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr 
                165                 170                 175


Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe 
            180                 185                 190


Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val 
        195                 200                 205


His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser 
    210                 215                 220


Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp 
225                 230                 235                 240


Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu 
                245                 250                 255


Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys 
            260                 265                 270


Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr 
        275                 280                 285


Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val 
    290                 295                 300


His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu 
305                 310                 315                 320


Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu 
                325                 330                 335


Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys 
            340                 345                 350


Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu 
        355                 360                 365


Asp Ile Arg Val Gly Lys Ile Ile Thr Val Glu Lys His Pro Asp Ala 
    370                 375                 380


Asp Ser Leu Tyr Val Glu Lys Ile Asp Val Gly Glu Ala Glu Pro Arg 
385                 390                 395                 400


Thr Val Val Ser Gly Leu Val Gln Phe Val Pro Lys Glu Glu Leu Gln 
                405                 410                 415


Asp Arg Leu Val Val Val Leu Cys Asn Leu Lys Pro Gln Lys Met Arg 
            420                 425                 430


Gly Val Glu Ser Gln Gly Met Leu Leu Cys Ala Ser Ile Glu Gly Ile 
        435                 440                 445


Asn Arg Gln Val Glu Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro Gly 
    450                 455                 460


Glu His Val Phe Val Lys Gly Tyr Glu Lys Gly Gln Pro Asp Glu Glu 
465                 470                 475                 480


Leu Lys Pro Lys Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Lys 
                485                 490                 495


Ile Ser Glu Glu Cys Ile Ala Gln Trp Lys Gln Thr Asn Phe Met Thr 
            500                 505                 510


Lys Leu Gly Ser Ile Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile Ser 
        515                 520                 525


<210>  1744
<211>  777
<212>  DNA
<213>  Homo sapiens

<400>  1744
ctgacttcaa aatttctgag gagtgcatcg cacagtggaa gcaaaccaac ttcatgacca     60

agctgggctc catttcctgt aaatcgctga aaggggggaa cattagctag ccagcccagc    120

atcttccccc cttcttccac cactgagtca tctgctgtct cttcaaactc ggcaaggggc    180

agcttaccct ccccagaacc caggatcatc ctgtctggct gcagtgagag accaacccct    240

aacaagggct gggccacagc agggagtcca gccctacctt cttcccttgg cagctggaga    300

aatctggttt caatataact catttaaaaa tttatgccac agtccttata attggaaaaa    360

tactggtgcc caggttttct tggagttatc caagcagctg cgcccctagc tgggatctgg    420

tacctggact aggctaatta cagcttctcc ccaacaggaa actgtgggat ttgaaaagga    480

aagggaaggg aaaacagaga acctagtggt ctaccaagtg gttggcaact ttcccaatgt    540

ctgcttactc tgaggcttgg cactgggggc cagggcctgc cccagggctc ctggaatttc    600

ccttgatcca gctaggctgg gacactccct aaatcagctg cgtgttgtta gcatcaggca    660

gaatgaatgg cagagagtga ttctgtcttc atagagggtg gggtacttct ccataaggca    720

tctcagtcaa atccccatca ctgtcataaa ttcaaataaa atgtctgaac aagggtg       777


<210>  1745
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  1745

Met Ser Ala Tyr Ser Glu Ala Trp His Trp Gly Pro Gly Pro Ala Pro 
1               5                   10                  15


Gly Leu Leu Glu Phe Pro Leu Ile Gln Leu Gly Trp Asp Thr Pro 
            20                  25                  30


<210>  1746
<211>  503
<212>  DNA
<213>  Homo sapiens

<400>  1746
ccagatgcag acagcctgta tgtagagaag attgacgtgg gggaagctga accacggact     60

gtggtgagcg gcctggtaca gttcgtgccc aaggaggaac tgcaggacag gctggtagtg    120

cagctgcgcc cctagctggg atctggtacc tggactaggc taattacagc ttctccccaa    180

caggaaactg tgggatttga aaaggaaagg gaagggaaaa cagagaacct agtggtctac    240

caagtggttg gcaactttcc caatgtctgc ttactctgag gcttggcact gggggccagg    300

gcctgcccca gggctcctgg aatttccctt gatccagcta ggctgggaca ctccctaaat    360

cagctgcgtg ttgttagcat caggcagaat gaatggcaga gagtgattct gtcttcatag    420

agggtggggt acttctccat aaggcatctc agtcaaatcc ccatcactgt cataaattca    480

aataaaatgt ctgaacaagg gtg                                            503


<210>  1747
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  1747

Met Ser Ala Tyr Ser Glu Ala Trp His Trp Gly Pro Gly Pro Ala Pro 
1               5                   10                  15


Gly Leu Leu Glu Phe Pro Leu Ile Gln Leu Gly Trp Asp Thr Pro 
            20                  25                  30


<210>  1748
<211>  2185
<212>  DNA
<213>  Homo sapiens

<400>  1748
ttcagaaagt ggtggaggga agacttcctt tttcccagag acagaaggtt atgcacccag     60

tggcctggga ccattgttct gggctttttt tcccttcgac atggatttgc ttctcactgt    120

gtaccccaac caccaaaacc accctgagat caatgctggt gctcctgcat cagatggctt    180

agagatcctt ccacctctta acacaagcat ctaggtccac tttactcaaa tctggcctca    240

gttgagagca gagtatacca tcagagccca ttctcctgtc tgctgtctgg gacgtggaaa    300

gaaagttagc tctagggggt ctttccaggg gcctctgtaa ggagtggatg ctcctttccg    360

gaatccaaga gttcaccagg ctgcttctct aatggacgat gatcctcttc ctcctgacgt    420

ctctccctgg cagcacccag atgcagacag cctgtatgta gagaagattg acgtggggga    480

agctgaacca cggactgtgg tgagcggcct ggtacagttc gtgcccaagg aggaactgca    540

ggacaggctg gtagtggtgc tgtgcaacct gaaaccccag aagatgagag gagtcgagtc    600

ccaaggcatg cttctgtgtg cttctatgtg agtgaggact tggagtgggg cacaggacct    660

ggggaggcca ggaagagtag ggaatcagcc catatgatgt ccttccacac accaggtgga    720

agctctgaga acacgtgcct cttccttgct gatgccaaaa gttgatgcat gaaggactta    780

tcgtacaagt actgttaatg aagcatttta cctacagtta attttgttaa aatagaaatg    840

gagggctcaa accagtacat acccaagtct tactactagt aaggagtgga gcagggattc    900

aaatcccagt tttgatgtct ataaagtcct cgctacgtta ttttatactt cctcccctag    960

aaacacagat tttggtatct tgacacacaa ttttggtata gcctgggtta atgtaaccct   1020

ggtgatatgc agggatgtag caagataaga ggacctcctg gggctctggt actgaggatg   1080

ccctaaatcc catcagggcc cctgtgtaaa ggcccggatt gctttggcct ccacagtcac   1140

tggaacccat ccatagcctc actcttctct tgtcctgtgt cttcccagag aagggataaa   1200

ccgccaggtt gaacctctgg accctccggc aggctctgct cctggtgagc acgtgtttgt   1260

gaagggctat gaaaagggcc aaccagatga ggagctcaag cccaagaaga aagtcttcga   1320

gaagttgcag gctgacttca aaatttctga ggagtgcatc gcacagtgga agcaaaccaa   1380

cttcatgacc aagctgggct ccatttcctg taaatcgctg aaagggggga acattagcta   1440

gccagcccag catcttcccc ccttcttcca ccactgagtc atctgctgtc tcttcagtct   1500

gctccatcca tcacccattt acccatctct caggacacgg aagcagcggg tttggactct   1560

ttattcggtg cagaactcgg caaggggcag cttaccctcc ccagaaccca ggatcatcct   1620

gtctggctgc agtgagagac caacccctaa caagggctgg gccacagcag ggagtccagc   1680

cctaccttct tcccttggca gctggagaaa tctggtttca atataactca tttaaaaatt   1740

tatgccacag tccttataat tggaaaaata ctggtgccca ggttttcttg gagttatcca   1800

agcagctgcg cccctagctg ggatctggta cctggactag gctaattaca gcttctcccc   1860

aacaggaaac tgtgggattt gaaaaggaaa gggaagggaa aacagagaac ctagtggtct   1920

accaagtggt tggcaacttt cccaatgtct gcttactctg aggcttggca ctgggggcca   1980

gggcctgccc cagggctcct ggaatttccc ttgatccagc taggctggga cactccctaa   2040

atcagctgcg tgttgttagc atcaggcaga atgaatggca gagagtgatt ctgtcttcat   2100

agagggtggg gtacttctcc ataaggcatc tcagtcaaat ccccatcact gtcataaatt   2160

caaataaaat gtctgaacaa gggtg                                         2185


<210>  1749
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  1749

Met Lys Arg Ala Asn Gln Met Arg Ser Ser Ser Pro Arg Arg Lys Ser 
1               5                   10                  15


Ser Arg Ser Cys Arg Leu Thr Ser Lys Phe Leu Arg Ser Ala Ser His 
            20                  25                  30


Ser Gly Ser Lys Pro Thr Ser 
        35


<210>  1750
<211>  2693
<212>  DNA
<213>  Homo sapiens

<400>  1750
gattctgcag gttgtacatc ctggagacct gaagaattct gttgaagtcg cactgaacaa     60

gttgctggat ccaatccggg aaaagtttaa tacccctgcc ctgaaaaaac tggccagcgc    120

tgcctaccca gatccctcaa agcagagtaa ggccagctgg agaggggccg acatcatcag    180

gagagagagc ttgtcaatga gccttggaaa aatgcctgtc ttaaattgag ggcacaacaa    240

cccagggggt ctgaagtgca ggaatgtcat gtcctactgg ctcctagaat ggaacttgag    300

tcattttgat ttgggtttgg ttaacatcag gaagtgatca catccttttg taccggcatt    360

gctgagagct gctggtgtaa gatgtatact ttggtccttc tagtctgttt gttaaatctg    420

cctcttcatt aaagatagtg accggggcca gacacagtgg ctcacacctg taatcttaac    480

actttggaag gctgaggcag gcggatcact tgagcccaaa agttagagac caaaacccag    540

tctctaccca aaaaaaaaaa aaaaaaaaat tagccaggca tagtagcaca tgcctgtagt    600

cccagctact tgggaggctg aggtgagagg atcacctgag catggggaag ttgagactgc    660

agtgagccat gatcgcacca ctgcactcca gcctgggcaa cagagtgaga ctctatgtct    720

caaaaaaaga aaaatgatag aaattagatt agacctatta tacccaaccg gtatataggg    780

tatcgatagt ttcttacaca gctgttgggc agagcctgca gagcttagag aagcttatct    840

ttagattctc ccagtttcct tctatgtgca tgggcctggc tcttagttgg ccatccactt    900

gtgcgtaatg ctaagatatt ggcattgata gctttgtgcg acccttccag aaaaaaactc    960

agtaactcag taaaattttt tttttttttt tctaaaagag acagagtctg gctctgttgc   1020

ccagcctggt cttgaagtcc tgggcttaag caatcctccc gtctcagcct cccaaagtgc   1080

tagaattaca ggtgtgagct accacacctg gccaagactc agtaaattct atgtggaatg   1140

catgaatgga aatacctaaa ggaggcaaag ctactactgc tccctccccg ctagtctaat   1200

aattgaggga gagaacagat gaaaatcagg tatgtcatgt ctgaaaggtt gccaacccag   1260

tattaaagaa gttacaactc agtgtttaga ctctggggat tctacactaa atcttaccta   1320

atctcagtgt cttaacgtgg tgggatcagc agctgacctg ccacagggaa gaattctacc   1380

tcatggggtt cttctcattc ccagagccaa tggccaaagg ccctgccaag aattcagaac   1440

cagaggaggt catcccatcc cggctggata tccgtgtggg gaaaatcatc actgtggaga   1500

agcacccaga tgcagacagc ctgtatgtag agaagattga cgtgggggaa gctgaaccac   1560

ggactgtggt gagcggcctg gtacagttcg tgcccaagga ggaactgcag gacaggctgg   1620

tagtggtgct gtgcaacctg aaaccccaga agatgagagg agtcgagtcc caaggcatgc   1680

ttctgtgtgc ttctatagaa gggataaacc gccaggttga acctctggac cctccggcag   1740

gctctgctcc tggtgagcac gtgtttgtga agggctatga aaagggccaa ccagatgagg   1800

agctcaagcc caagaagaaa gtcttcgaga agttgcaggc tgacttcaaa atttctgagg   1860

agtgcatcgc acagtggaag caaaccaact tcatgaccaa gctgggctcc atttcctgta   1920

aatcgctgaa aggggggaac attagctagc cagcccagca tcttcccccc ttcttccacc   1980

actgagtcat ctgctgtctc ttcagtctgc tccatccatc acccatttac ccatctctca   2040

ggacacggaa gcagcgggtt tggactcttt attcggtgca gaactcggca aggggcagct   2100

taccctcccc agaacccagg atcatcctgt ctggctgcag tgagagacca acccctaaca   2160

agggctgggc cacagcaggg agtccagccc taccttcttc ccttggcagc tggagaaatc   2220

tggtttcaat ataactcatt taaaaattta tgccacagtc cttataattg gaaaaatact   2280

ggtgcccagg ttttcttgga gttatccaag cagctgcgcc cctagctggg atctggtacc   2340

tggactaggc taattacagc ttctccccaa caggaaactg tgggatttga aaaggaaagg   2400

gaagggaaaa cagagaacct agtggtctac caagtggttg gcaactttcc caatgtctgc   2460

ttactctgag gcttggcact gggggccagg gcctgcccca gggctcctgg aatttccctt   2520

gatccagcta ggctgggaca ctccctaaat cagctgcgtg ttgttagcat caggcagaat   2580

gaatggcaga gagtgattct gtcttcatag agggtggggt acttctccat aaggcatctc   2640

agtcaaatcc ccatcactgt cataaattca aataaaatgt ctgaacaagg gtg          2693


<210>  1751
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  1751

Met Gly Phe Phe Ser Phe Pro Glu Pro Met Ala Lys Gly Pro Ala Lys 
1               5                   10                  15


Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu Asp Ile Arg Val 
            20                  25                  30


Gly Lys Ile Ile Thr Val Glu Lys His Pro Asp Ala Asp Ser Leu Tyr 
        35                  40                  45


Val Glu Lys Ile Asp Val Gly Glu Ala Glu Pro Arg Thr Val Val Ser 
    50                  55                  60


Gly Leu Val Gln Phe Val Pro Lys Glu Glu Leu Gln Asp Arg Leu Val 
65                  70                  75                  80


Val Val Leu Cys Asn Leu Lys Pro Gln Lys Met Arg Gly Val Glu Ser 
                85                  90                  95


Gln Gly Met Leu Leu Cys Ala Ser Ile Glu Gly Ile Asn Arg Gln Val 
            100                 105                 110


Glu Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro Gly Glu His Val Phe 
        115                 120                 125


Val Lys Gly Tyr Glu Lys Gly Gln Pro Asp Glu Glu Leu Lys Pro Lys 
    130                 135                 140


Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Lys Ile Ser Glu Glu 
145                 150                 155                 160


Cys Ile Ala Gln Trp Lys Gln Thr Asn Phe Met Thr Lys Leu Gly Ser 
                165                 170                 175


Ile Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile Ser 
            180                 185


<210>  1752
<211>  2731
<212>  DNA
<213>  Homo sapiens

<400>  1752
aagaactgaa tttcagttta catttaaata cccacacaag gctagtagcc accatattgg     60

acagcagcag ccctagagct tttattaaaa ttaaatattc ccaaggaaat gaagaagtag    120

tatcagaaac aaaaatgttc gctttgttgt attaaaagtg ttcattccta agggatgtcc    180

cctcagaata tctagaagat tctttcagac cagatttgag atataaaaaa ggcagtcagc    240

tgggcgtggt ggctcacacc tgtaatccca gcactttggg aggctgaggc aggtggatca    300

cgaggtcagg agttcaagac cagtctgggc aacatggtga aaccccgtct ctactaaaat    360

acaaaaaatt agctgggcgt ggctgcatgc gcctgtagtc ccagctactc aggaggctga    420

ggcaggagaa ttgcttgagc tcaggaggca gaggttgcaa tgagctgaga ttgcgccact    480

gcaccccagc ctgggcgacg gagcaagact ccgtctcaaa gaaaaggcag tcacaggaca    540

caaggaataa aatggaatta ctgaactatt accatgtacg agcagcgttc tcatcatttt    600

cacacccaca ttcagtgatt taaccctcat ccccatcctg tgagatatag ctgttgttag    660

cttcacttta taagtaacaa agccaacact ggcccggcac gttggcccat gcctgtaatc    720

ctagcacttt gggaggcaga agcaggcaga ttgcctgaac ccaggagttc aagaccagcc    780

tgggtaacat agcaagaccc tgtctctaca aaaagaaaag agaaaaagca gcagccaaag    840

cttagagggg ttatgtgcct agtttggagt cgcacacagc tagctgggaa tctaatctgg    900

gtctgtcgaa ctccaaagcc cttcctcttt cttcttactc agctgtctcc ctcaggttat    960

ctttaggcct tgggttacct atgtgaatgt ttctctgctt gtaaatacca gttggtctgt   1020

gaccctactc taagcataaa tggagggact agaagaatta gactaacaaa tacattcagc   1080

tcctaaacac cctcaagtta gtatagattt cagaatcaaa agacttggat tttggacacg   1140

ttagtctttc tgaatgtatt ttcccttctc ctacctgcct cacaagatta tcacaaggat   1200

caaataagac tgttgggaaa aactcccttg atcctacttt tttggattca ggtgtcctgt   1260

gccctgttct agactttatc tcactaggtc ttgttcgatt ctgcaggttg tacatcctgg   1320

agacctgaag aattctgttg aagtcgcact gaacaagttg ctggatccaa tccgggaaaa   1380

gtttaatacc cctgccctga aaaaactggc cagcgctgcc tacccagatc cctcaaagca   1440

gaagccaatg gccaaaggcc ctgccaagaa ttcagaacca gaggaggtca tcccatcccg   1500

gctggatatc cgtgtgggga aaatcatcac tgtggagaag cacccagatg cagacagcct   1560

gtatgtagag aagattgacg tgggggaagc tgaaccacgg actgtggtga gcggcctggt   1620

acagttcgtg cccaaggagg aactgcagga caggctggta gtggtgctgt gcaacctgaa   1680

accccagaag atgagaggag tcgagtccca aggcatgctt ctgtgtgctt ctatagaagg   1740

gataaaccgc caggttgaac ctctggaccc tccggcaggc tctgctcctg gtgagcacgt   1800

gtttgtgaag ggctatgaaa agggccaacc agatgaggag ctcaagccca agaagaaagt   1860

cttcgagaag ttgcaggctg acttcaaaat ttctgaggag tgcatcgcac agtggaagca   1920

aaccaacttc atgaccaagc tgggctccat ttcctgtaaa tcgctgaaag gggggaacat   1980

tagctagcca gcccagcatc ttcccccctt cttccaccac tgagtcatct gctgtctctt   2040

cagtctgctc catccatcac ccatttaccc atctctcagg acacggaagc agcgggtttg   2100

gactctttat tcggtgcaga actcggcaag gggcagctta ccctccccag aacccaggat   2160

catcctgtct ggctgcagtg agagaccaac ccctaacaag ggctgggcca cagcagggag   2220

tccagcccta ccttcttccc ttggcagctg gagaaatctg gtttcaatat aactcattta   2280

aaaatttatg ccacagtcct tataattgga aaaatactgg tgcccaggtt ttcttggagt   2340

tatccaagca gctgcgcccc tagctgggat ctggtacctg gactaggcta attacagctt   2400

ctccccaaca ggaaactgtg ggatttgaaa aggaaaggga agggaaaaca gagaacctag   2460

tggtctacca agtggttggc aactttccca atgtctgctt actctgaggc ttggcactgg   2520

gggccagggc ctgccccagg gctcctggaa tttcccttga tccagctagg ctgggacact   2580

ccctaaatca gctgcgtgtt gttagcatca ggcagaatga atggcagaga gtgattctgt   2640

cttcatagag ggtggggtac ttctccataa ggcatctcag tcaaatcccc atcactgtca   2700

taaattcaaa taaaatgtct gaacaagggt g                                  2731


<210>  1753
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  1753

Met Ala Lys Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro 
1               5                   10                  15


Ser Arg Leu Asp Ile Arg Val Gly Lys Ile Ile Thr Val Glu Lys His 
            20                  25                  30


Pro Asp Ala Asp Ser Leu Tyr Val Glu Lys Ile Asp Val Gly Glu Ala 
        35                  40                  45


Glu Pro Arg Thr Val Val Ser Gly Leu Val Gln Phe Val Pro Lys Glu 
    50                  55                  60


Glu Leu Gln Asp Arg Leu Val Val Val Leu Cys Asn Leu Lys Pro Gln 
65                  70                  75                  80


Lys Met Arg Gly Val Glu Ser Gln Gly Met Leu Leu Cys Ala Ser Ile 
                85                  90                  95


Glu Gly Ile Asn Arg Gln Val Glu Pro Leu Asp Pro Pro Ala Gly Ser 
            100                 105                 110


Ala Pro Gly Glu His Val Phe Val Lys Gly Tyr Glu Lys Gly Gln Pro 
        115                 120                 125


Asp Glu Glu Leu Lys Pro Lys Lys Lys Val Phe Glu Lys Leu Gln Ala 
    130                 135                 140


Asp Phe Lys Ile Ser Glu Glu Cys Ile Ala Gln Trp Lys Gln Thr Asn 
145                 150                 155                 160


Phe Met Thr Lys Leu Gly Ser Ile Ser Cys Lys Ser Leu Lys Gly Gly 
                165                 170                 175


Asn Ile Ser 



<210>  1754
<211>  2056
<212>  DNA
<213>  Homo sapiens

<400>  1754
gaacaatggg gttctgtcct tcatcaagca tgtccttttt ccccttaagt ccggtaacac     60

tctctgtttt cttcctagag gccaggctag aatagaaaag ttcgtgctgt gatcatactt    120

gtgatttgtc acagactctt ccttcaggga ctggctgccc tgattctctg ctctgatttc    180

ttatatatta aagtatgaat gatgttggga tgtaatttaa ttgtccatat attcgttacc    240

aggctaggtt ctgagggaat actggagtgg gcagaggtgt tagaagtaag ggtgggggca    300

gacatgttga actagaggaa tacaacaaaa tagatataag ccacaagcct tcccctgaag    360

cagctgagat gctagctggg tatacaatag tgccactcat ccaatttaag aataatacca    420

tacaataaag ttcagaatat atggcaaaaa ctacaaatag tcatgcatgt gggctaggaa    480

tagtcatgca tgtgagctag gaatgctgtc aatgagtttg ttgacatgga tccttttcct    540

tatagagttt gtgatcctac gagatgagaa atggggtgga aacaaaacct acacagctta    600

cgtggacctg gaaaaggact ttgctgctga ggttgtacat cctggagacc tgaagaattc    660

tgttgaagtc gcactgaaca agttgctgga tccaatccgg gaaaagttta atacccctgc    720

cctgaaaaaa ctggccagcg ctgcctaccc agatccctca aagcagaagc caatggccaa    780

aggccctgcc aagaattcag aaccagagga ggtcatccca tcccggctgg atatccgtgt    840

ggggaaaatc atcactgtgg agaagcaccc agatgcagac agcctgtatg tagagaagat    900

tgacgtgggg gaagctgaac cacggactgt ggtgagcggc ctggtacagt tcgtgcccaa    960

ggaggaactg caggacaggc tggtagtggt gctgtgcaac ctgaaacccc agaagatgag   1020

aggagtcgag tcccaaggca tgcttctgtg tgcttctata gaagggataa accgccaggt   1080

tgaacctctg gaccctccgg caggctctgc tcctggtgag cacgtgtttg tgaagggcta   1140

tgaaaagggc caaccagatg aggagctcaa gcccaagaag aaagtcttcg agaagttgca   1200

ggctgacttc aaaatttctg aggagtgcat cgcacagtgg aagcaaacca acttcatgac   1260

caagctgggc tccatttcct gtaaatcgct gaaagggggg aacattagct agccagccca   1320

gcatcttccc cccttcttcc accactgagt catctgctgt ctcttcagtc tgctccatcc   1380

atcacccatt tacccatctc tcaggacacg gaagcagcgg gtttggactc tttattcggt   1440

gcagaactcg gcaaggggca gcttaccctc cccagaaccc aggatcatcc tgtctggctg   1500

cagtgagaga ccaaccccta acaagggctg ggccacagca gggagtccag ccctaccttc   1560

ttcccttggc agctggagaa atctggtttc aatataactc atttaaaaat ttatgccaca   1620

gtccttataa ttggaaaaat actggtgccc aggttttctt ggagttatcc aagcagctgc   1680

gcccctagct gggatctggt acctggacta ggctaattac agcttctccc caacaggaaa   1740

ctgtgggatt tgaaaaggaa agggaaggga aaacagagaa cctagtggtc taccaagtgg   1800

ttggcaactt tcccaatgtc tgcttactct gaggcttggc actgggggcc agggcctgcc   1860

ccagggctcc tggaatttcc cttgatccag ctaggctggg acactcccta aatcagctgc   1920

gtgttgttag catcaggcag aatgaatggc agagagtgat tctgtcttca tagagggtgg   1980

ggtacttctc cataaggcat ctcagtcaaa tccccatcac tgtcataaat tcaaataaaa   2040

tgtctgaaca agggtg                                                   2056


<210>  1755
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  1755

Met Trp Ala Arg Asn Ser His Ala Cys Glu Leu Gly Met Leu Ser Met 
1               5                   10                  15


Ser Leu Leu Thr Trp Ile Leu Phe Leu Ile Glu Phe Val Ile Leu Arg 
            20                  25                  30


Asp Glu Lys Trp Gly Gly Asn Lys Thr Tyr Thr Ala Tyr Val Asp Leu 
        35                  40                  45


Glu Lys Asp Phe Ala Ala Glu Val Val His Pro Gly Asp Leu Lys Asn 
    50                  55                  60


Ser Val Glu Val Ala Leu Asn Lys Leu Leu Asp Pro Ile Arg Glu Lys 
65                  70                  75                  80


Phe Asn Thr Pro Ala Leu Lys Lys Leu Ala Ser Ala Ala Tyr Pro Asp 
                85                  90                  95


Pro Ser Lys Gln Lys Pro Met Ala Lys Gly Pro Ala Lys Asn Ser Glu 
            100                 105                 110


Pro Glu Glu Val Ile Pro Ser Arg Leu Asp Ile Arg Val Gly Lys Ile 
        115                 120                 125


Ile Thr Val Glu Lys His Pro Asp Ala Asp Ser Leu Tyr Val Glu Lys 
    130                 135                 140


Ile Asp Val Gly Glu Ala Glu Pro Arg Thr Val Val Ser Gly Leu Val 
145                 150                 155                 160


Gln Phe Val Pro Lys Glu Glu Leu Gln Asp Arg Leu Val Val Val Leu 
                165                 170                 175


Cys Asn Leu Lys Pro Gln Lys Met Arg Gly Val Glu Ser Gln Gly Met 
            180                 185                 190


Leu Leu Cys Ala Ser Ile Glu Gly Ile Asn Arg Gln Val Glu Pro Leu 
        195                 200                 205


Asp Pro Pro Ala Gly Ser Ala Pro Gly Glu His Val Phe Val Lys Gly 
    210                 215                 220


Tyr Glu Lys Gly Gln Pro Asp Glu Glu Leu Lys Pro Lys Lys Lys Val 
225                 230                 235                 240


Phe Glu Lys Leu Gln Ala Asp Phe Lys Ile Ser Glu Glu Cys Ile Ala 
                245                 250                 255


Gln Trp Lys Gln Thr Asn Phe Met Thr Lys Leu Gly Ser Ile Ser Cys 
            260                 265                 270


Lys Ser Leu Lys Gly Gly Asn Ile Ser 
        275                 280


<210>  1756
<211>  3260
<212>  DNA
<213>  Homo sapiens

<400>  1756
aaacccgccc ctcagcaggc ctgtgctgtg cgctcctctc ccggggacca ccgtcctcag     60

atctccccag ggaatgggtc gtcctcttcc tgcccccacc cgcgagacgc ggcagaaaag    120

cccgcggcta tcttcccgcc agcaacagcc tcccgccgag ccggccggga cagaggcggc    180

ccccaccccc actgggcagg ggactgcaga cggcgctccc cgactctcaa gacgaccagg    240

gagcttccct tttcctcagc ggggtgaggg gcatctgtcg cccgccgact tggaggtgga    300

ggggcaggga cattccctcg ccatcacctc aggagctaga acgcgccctt ctcgcagcag    360

ggcgtgggcc tcccaatccc tccaaggggc ggacggcgtg cgcaaccccc tggagaagca    420

acaggcgccc ccatccccct ccaagccggg taacgccgac cccctcgtcc ctcccgctct    480

tcacctccgg aagccgggcc aaagcctggg cgaacgactg cgcctcactc cgccccctgc    540

gccattttat cgccccctcc ccgacctccc ctaccccgag tcagccgggc caacaccagg    600

gggagggcaa accagcagtg attggcagga aaccgtcccg cctctaggag ggttgtgccc    660

cgctcaggcg cctcagcccc gccctccgca ccgcccaccg tgcccactgg ctccaccttt    720

tcccgtctca tcgacctgct cgactctctg ctgctcctca ctttttccgg ccgctgccgg    780

aggggtccag gccgagtaag cggagcgccg agcccagctg atgcaacctg gctggactcg    840

cgtgacagtt cccggcacgc ggcggcgacg gtgacccagg aaggggctct ggtgccgggc    900

tgagcggggg aagcaggggt agcggagcca tgggggacgc tcccagccct gaagagaaac    960

tgcaccttat cacccggaac ctgcaggagg ttctggggga agagaagctg aaggagatac   1020

tgaaggagcg ggaacttaaa atttactggg gaacggcaac cacgggcaaa ccacatgtgg   1080

cttactttgt gcccatgtca aagattgcag acttcttaaa ggcagggtgt gaggtaacaa   1140

ttctgtttgc ggacctccac gcatacctgg ataacatgaa agccccatgg gaacttctag   1200

aactccgagt cagttactat gagaatgtga tcaaagcaat gctggagagc attggtgtgc   1260

ccttggagaa gctcaagttc atcaaaggca ctgattacca gctcagcaaa gagtacacac   1320

tagatgtgta cagactctcc tccgtggtca cacagcacga ttccaagaag gctggagctg   1380

aggtggtaaa gcaggtggag caccctttgc tgagtggcct cttatacccc ggactgcagg   1440

ctttggatga agagtattta aaagtagatg cccaatttgg aggcattgat cagagaaaga   1500

ttttcacctt tgcagagaag tacctccctg cacttggcta ttcaaaacgg gtccatctga   1560

tgaatcctat ggttccagga ttaacaggca gcaaaatgag ctcttcagaa gaggagtcca   1620

agattgatct ccttgatcgg aaggaggatg tgaagaaaaa actgaagaag gccttctgtg   1680

agccaggaaa tgtggagaac aatggggttc tgtccttcat caagcatgtc ctttttcccc   1740

ttaagtccga gtttgtgatc ctacgagatg agaaatgggg tggaaacaaa acctacacag   1800

cttacgtgga cctggaaaag gactttgctg ctgaggttgt acatcctgga gacctgaaga   1860

attctgttga agtcgcactg aacaagttgc tggatccaat ccgggaaaag tttaataccc   1920

ctgccctgaa aaaactggcc agcgctgcct acccagatcc ctcaaagcag aagccaatgg   1980

ccaaaggccc tgccaagaat tcagaaccag aggaggtcat cccatcccgg ctggatatcc   2040

gtgtggggaa aatcatcact gtggagaagc acccagatgc agacagcctg tatgtagaga   2100

agattgacgt gggggaagct gaaccacgga ctgtggtgag cggcctggta cagttcgtgc   2160

ccaaggagga actgcaggac aggctggtag tggtgctgtg caacctgaaa ccccagaaga   2220

tgagaggagt cgagtcccaa ggcatgcttc tgtgtgcttc tatagaaggg ataaaccgcc   2280

aggttgaacc tctggaccct ccggcaggct ctgctcctgg tgagcacgtg tttgtgaagg   2340

gctatgaaaa gggccaacca gatgaggagc tcaagcccaa gaagaaagtc ttcgagaagt   2400

tgcaggctga cttcaaaatt tctgaggagt gcatcgcaca gtggaagcaa accaacttca   2460

tgaccaagct gggctccatt tcctgtaaat cgctgaaagg ggggaacatt agctagccag   2520

cccagcatct tccccccttc ttccaccact gagtcatctg ctgtctcttc agtctgctcc   2580

atccatcacc catttaccca tctctcagga cacggaagca gcgggtttgg actctttatt   2640

cggtgcagaa ctcggcaagg ggcagcttac cctccccaga acccaggatc atcctgtctg   2700

gctgcagtga gagaccaacc cctaacaagg gctgggccac agcagggagt ccagccctac   2760

cttcttccct tggcagctgg agaaatctgg tttcaatata actcatttaa aaatttatgc   2820

cacagtcctt ataattggaa aaatactggt gcccaggttt tcttggagtt atccaagcag   2880

ctgcgcccct agctgggatc tggtacctgg actaggctaa ttacagcttc tccccaacag   2940

gaaactgtgg gatttgaaaa ggaaagggaa gggaaaacag agaacctagt ggtctaccaa   3000

gtggttggca actttcccaa tgtctgctta ctctgaggct tggcactggg ggccagggcc   3060

tgccccaggg ctcctggaat ttcccttgat ccagctaggc tgggacactc cctaaatcag   3120

ctgcgtgttg ttagcatcag gcagaatgaa tggcagagag tgattctgtc ttcatagagg   3180

gtggggtact tctccataag gcatctcagt caaatcccca tcactgtcat aaattcaaat   3240

aaaatgtctg aacaagggtg                                               3260


<210>  1757
<211>  528
<212>  PRT
<213>  Homo sapiens

<400>  1757

Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg 
1               5                   10                  15


Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys 
            20                  25                  30


Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro 
        35                  40                  45


His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys 
    50                  55                  60


Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu 
65                  70                  75                  80


Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr 
                85                  90                  95


Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu 
            100                 105                 110


Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu 
        115                 120                 125


Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp 
    130                 135                 140


Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu 
145                 150                 155                 160


Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr 
                165                 170                 175


Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe 
            180                 185                 190


Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val 
        195                 200                 205


His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser 
    210                 215                 220


Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp 
225                 230                 235                 240


Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu 
                245                 250                 255


Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys 
            260                 265                 270


Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr 
        275                 280                 285


Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val 
    290                 295                 300


His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu 
305                 310                 315                 320


Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu 
                325                 330                 335


Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys 
            340                 345                 350


Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu 
        355                 360                 365


Asp Ile Arg Val Gly Lys Ile Ile Thr Val Glu Lys His Pro Asp Ala 
    370                 375                 380


Asp Ser Leu Tyr Val Glu Lys Ile Asp Val Gly Glu Ala Glu Pro Arg 
385                 390                 395                 400


Thr Val Val Ser Gly Leu Val Gln Phe Val Pro Lys Glu Glu Leu Gln 
                405                 410                 415


Asp Arg Leu Val Val Val Leu Cys Asn Leu Lys Pro Gln Lys Met Arg 
            420                 425                 430


Gly Val Glu Ser Gln Gly Met Leu Leu Cys Ala Ser Ile Glu Gly Ile 
        435                 440                 445


Asn Arg Gln Val Glu Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro Gly 
    450                 455                 460


Glu His Val Phe Val Lys Gly Tyr Glu Lys Gly Gln Pro Asp Glu Glu 
465                 470                 475                 480


Leu Lys Pro Lys Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Lys 
                485                 490                 495


Ile Ser Glu Glu Cys Ile Ala Gln Trp Lys Gln Thr Asn Phe Met Thr 
            500                 505                 510


Lys Leu Gly Ser Ile Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile Ser 
        515                 520                 525


<210>  1758
<211>  797
<212>  DNA
<213>  Homo sapiens

<400>  1758
atacttcctc ccctagaaac acagattttg gtatcttgac acacaatttt ggtatagcct     60

gggttaatgt aaccctggtg atatgcaggg atgtagcaag ataagaggac ctcctggggc    120

tctggtactg aggatgccct aaatcccatc agggcccctg tgtaaaggcc cggattgctt    180

tggcctccac agtcactgga acccatccat agcctcactc ttctcttgtc ctgtgtcttc    240

ccagagaagg gataaaccgc caggttgaac ctctggaccc tccggcaggc tctgctcctg    300

gtgagcacgt gtttgtgaag ggctatgaaa agggccaacc agatgaggag ctcaagccca    360

agaagaaagt cttcgagaag ttgcaggctg acttcaaaat ttctgaggag tgcatcgcac    420

agtggaagca aaccaacttc atgaccaagc tgggctccat ttcctgtaaa tcgctgaaag    480

gggggaacat tagctagcca gcccagcatc ttcccccctt cttccaccac tgagtcatct    540

gctgtctctt cagtctgctc catccatcac ccatttaccc atctctcagg acacggaagc    600

agcgggtttg gactctttat tcggtgcaga actcggcaag gggcagctta ccctccccag    660

aacccaggat catcctgtct ggctgcagtg agagaccaac ccctaacaag ggctgggcca    720

cagcagggag tccagcccta ccttcttccc ttggcagctg gagaaatctg gtttcaatat    780

aactcattta aaaattt                                                   797


<210>  1759
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  1759

Met Lys Arg Ala Asn Gln Met Arg Ser Ser Ser Pro Arg Arg Lys Ser 
1               5                   10                  15


Ser Arg Ser Cys Arg Leu Thr Ser Lys Phe Leu Arg Ser Ala Ser His 
            20                  25                  30


Ser Gly Ser Lys Pro Thr Ser 
        35


<210>  1760
<211>  2287
<212>  DNA
<213>  Homo sapiens

<400>  1760
aagaactgaa tttcagttta catttaaata cccacacaag gctagtagcc accatattgg     60

acagcagcag ccctagagct tttattaaaa ttaaatattc ccaaggaaat gaagaagtag    120

tatcagaaac aaaaatgttc gctttgttgt attaaaagtg ttcattccta agggatgtcc    180

cctcagaata tctagaagat tctttcagac cagatttgag atataaaaaa ggcagtcagc    240

tgggcgtggt ggctcacacc tgtaatccca gcactttggg aggctgaggc aggtggatca    300

cgaggtcagg agttcaagac cagtctgggc aacatggtga aaccccgtct ctactaaaat    360

acaaaaaatt agctgggcgt ggctgcatgc gcctgtagtc ccagctactc aggaggctga    420

ggcaggagaa ttgcttgagc tcaggaggca gaggttgcaa tgagctgaga ttgcgccact    480

gcaccccagc ctgggcgacg gagcaagact ccgtctcaaa gaaaaggcag tcacaggaca    540

caaggaataa aatggaatta ctgaactatt accatgtacg agcagcgttc tcatcatttt    600

cacacccaca ttcagtgatt taaccctcat ccccatcctg tgagatatag ctgttgttag    660

cttcacttta taagtaacaa agccaacact ggcccggcac gttggcccat gcctgtaatc    720

ctagcacttt gggaggcaga agcaggcaga ttgcctgaac ccaggagttc aagaccagcc    780

tgggtaacat agcaagaccc tgtctctaca aaaagaaaag agaaaaagca gcagccaaag    840

cttagagggg ttatgtgcct agtttggagt cgcacacagc tagctgggaa tctaatctgg    900

gtctgtcgaa ctccaaagcc cttcctcttt cttcttactc agctgtctcc ctcaggttat    960

ctttaggcct tgggttacct atgtgaatgt ttctctgctt gtaaatacca gttggtctgt   1020

gaccctactc taagcataaa tggagggact agaagaatta gactaacaaa tacattcagc   1080

tcctaaacac cctcaagtta gtatagattt cagaatcaaa agacttggat tttggacacg   1140

ttagtctttc tgaatgtatt ttcccttctc ctacctgcct cacaagatta tcacaaggat   1200

caaataagac tgttgggaaa aactcccttg atcctacttt tttggattca ggtgtcctgt   1260

gccctgttct agactttatc tcactaggtc ttgttcgatt ctgcaggttg tacatcctgg   1320

agacctgaag aattctgttg aagtcgcact gaacaagttg ctggatccaa tccgggaaaa   1380

gtttaatacc cctgccctga aaaaactggc cagcgctgcc tacccagatc cctcaaagca   1440

gaagccaatg gccaaaggcc ctgccaagaa ttcagaacca gaggaggtca tcccatcccg   1500

gctggatatc cgtgtgggga aaatcatcac tgtggagaag cacccagatg cagacagcct   1560

gtatgtagag aagattgacg tgggggaagc tgaaccacgg actgtggtga gcggcctggt   1620

acagttcgtg cccaaggagg aactgcagga caggctggta gtggtgctgt gcaacctgaa   1680

accccagaag atgagaggag tcgagtccca aggcatgctt ctgtgtgctt ctatagaagg   1740

gataaaccgc caggttgaac ctctggaccc tccggcaggc tctgctcctg gtgagcacgt   1800

gtttgtgaag ggctatgaaa agggccaacc agatgaggag ctcaagccca agaagaaagt   1860

cttcgagaag ttgcaggctg acttcaaaat ttctgaggag tgcatcgcac agtggaagca   1920

aaccaacttc atgaccaagc tgggctccat ttcctgtaaa tcgctgaaag gggggaacat   1980

tagctagcca gcccagcatc ttcccccctt cttccaccac tgagtcatct gctgtctctt   2040

cagtctgctc catccatcac ccatttaccc atctctcagg acacggaagc agcgggtttg   2100

gactctttat tcggtgcaga actcggcaag gggcagctta ccctccccag aacccaggat   2160

catcctgtct ggctgcagtg agagaccaac ccctaacaag ggctgggcca cagcagggag   2220

tccagcccta ccttcttccc ttggcagctg gagaaatctg gtttcaatat aactcattta   2280

aaaattt                                                             2287


<210>  1761
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  1761

Met Ala Lys Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro 
1               5                   10                  15


Ser Arg Leu Asp Ile Arg Val Gly Lys Ile Ile Thr Val Glu Lys His 
            20                  25                  30


Pro Asp Ala Asp Ser Leu Tyr Val Glu Lys Ile Asp Val Gly Glu Ala 
        35                  40                  45


Glu Pro Arg Thr Val Val Ser Gly Leu Val Gln Phe Val Pro Lys Glu 
    50                  55                  60


Glu Leu Gln Asp Arg Leu Val Val Val Leu Cys Asn Leu Lys Pro Gln 
65                  70                  75                  80


Lys Met Arg Gly Val Glu Ser Gln Gly Met Leu Leu Cys Ala Ser Ile 
                85                  90                  95


Glu Gly Ile Asn Arg Gln Val Glu Pro Leu Asp Pro Pro Ala Gly Ser 
            100                 105                 110


Ala Pro Gly Glu His Val Phe Val Lys Gly Tyr Glu Lys Gly Gln Pro 
        115                 120                 125


Asp Glu Glu Leu Lys Pro Lys Lys Lys Val Phe Glu Lys Leu Gln Ala 
    130                 135                 140


Asp Phe Lys Ile Ser Glu Glu Cys Ile Ala Gln Trp Lys Gln Thr Asn 
145                 150                 155                 160


Phe Met Thr Lys Leu Gly Ser Ile Ser Cys Lys Ser Leu Lys Gly Gly 
                165                 170                 175


Asn Ile Ser 



<210>  1762
<211>  1612
<212>  DNA
<213>  Homo sapiens

<400>  1762
gaacaatggg gttctgtcct tcatcaagca tgtccttttt ccccttaagt ccggtaacac     60

tctctgtttt cttcctagag gccaggctag aatagaaaag ttcgtgctgt gatcatactt    120

gtgatttgtc acagactctt ccttcaggga ctggctgccc tgattctctg ctctgatttc    180

ttatatatta aagtatgaat gatgttggga tgtaatttaa ttgtccatat attcgttacc    240

aggctaggtt ctgagggaat actggagtgg gcagaggtgt tagaagtaag ggtgggggca    300

gacatgttga actagaggaa tacaacaaaa tagatataag ccacaagcct tcccctgaag    360

cagctgagat gctagctggg tatacaatag tgccactcat ccaatttaag aataatacca    420

tacaataaag ttcagaatat atggcaaaaa ctacaaatag tcatgcatgt gggctaggaa    480

tagtcatgca tgtgagctag gaatgctgtc aatgagtttg ttgacatgga tccttttcct    540

tatagagttt gtgatcctac gagatgagaa atggggtgga aacaaaacct acacagctta    600

cgtggacctg gaaaaggact ttgctgctga ggttgtacat cctggagacc tgaagaattc    660

tgttgaagtc gcactgaaca agttgctgga tccaatccgg gaaaagttta atacccctgc    720

cctgaaaaaa ctggccagcg ctgcctaccc agatccctca aagcagaagc caatggccaa    780

aggccctgcc aagaattcag aaccagagga ggtcatccca tcccggctgg atatccgtgt    840

ggggaaaatc atcactgtgg agaagcaccc agatgcagac agcctgtatg tagagaagat    900

tgacgtgggg gaagctgaac cacggactgt ggtgagcggc ctggtacagt tcgtgcccaa    960

ggaggaactg caggacaggc tggtagtggt gctgtgcaac ctgaaacccc agaagatgag   1020

aggagtcgag tcccaaggca tgcttctgtg tgcttctata gaagggataa accgccaggt   1080

tgaacctctg gaccctccgg caggctctgc tcctggtgag cacgtgtttg tgaagggcta   1140

tgaaaagggc caaccagatg aggagctcaa gcccaagaag aaagtcttcg agaagttgca   1200

ggctgacttc aaaatttctg aggagtgcat cgcacagtgg aagcaaacca acttcatgac   1260

caagctgggc tccatttcct gtaaatcgct gaaagggggg aacattagct agccagccca   1320

gcatcttccc cccttcttcc accactgagt catctgctgt ctcttcagtc tgctccatcc   1380

atcacccatt tacccatctc tcaggacacg gaagcagcgg gtttggactc tttattcggt   1440

gcagaactcg gcaaggggca gcttaccctc cccagaaccc aggatcatcc tgtctggctg   1500

cagtgagaga ccaaccccta acaagggctg ggccacagca gggagtccag ccctaccttc   1560

ttcccttggc agctggagaa atctggtttc aatataactc atttaaaaat tt           1612


<210>  1763
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  1763

Met Trp Ala Arg Asn Ser His Ala Cys Glu Leu Gly Met Leu Ser Met 
1               5                   10                  15


Ser Leu Leu Thr Trp Ile Leu Phe Leu Ile Glu Phe Val Ile Leu Arg 
            20                  25                  30


Asp Glu Lys Trp Gly Gly Asn Lys Thr Tyr Thr Ala Tyr Val Asp Leu 
        35                  40                  45


Glu Lys Asp Phe Ala Ala Glu Val Val His Pro Gly Asp Leu Lys Asn 
    50                  55                  60


Ser Val Glu Val Ala Leu Asn Lys Leu Leu Asp Pro Ile Arg Glu Lys 
65                  70                  75                  80


Phe Asn Thr Pro Ala Leu Lys Lys Leu Ala Ser Ala Ala Tyr Pro Asp 
                85                  90                  95


Pro Ser Lys Gln Lys Pro Met Ala Lys Gly Pro Ala Lys Asn Ser Glu 
            100                 105                 110


Pro Glu Glu Val Ile Pro Ser Arg Leu Asp Ile Arg Val Gly Lys Ile 
        115                 120                 125


Ile Thr Val Glu Lys His Pro Asp Ala Asp Ser Leu Tyr Val Glu Lys 
    130                 135                 140


Ile Asp Val Gly Glu Ala Glu Pro Arg Thr Val Val Ser Gly Leu Val 
145                 150                 155                 160


Gln Phe Val Pro Lys Glu Glu Leu Gln Asp Arg Leu Val Val Val Leu 
                165                 170                 175


Cys Asn Leu Lys Pro Gln Lys Met Arg Gly Val Glu Ser Gln Gly Met 
            180                 185                 190


Leu Leu Cys Ala Ser Ile Glu Gly Ile Asn Arg Gln Val Glu Pro Leu 
        195                 200                 205


Asp Pro Pro Ala Gly Ser Ala Pro Gly Glu His Val Phe Val Lys Gly 
    210                 215                 220


Tyr Glu Lys Gly Gln Pro Asp Glu Glu Leu Lys Pro Lys Lys Lys Val 
225                 230                 235                 240


Phe Glu Lys Leu Gln Ala Asp Phe Lys Ile Ser Glu Glu Cys Ile Ala 
                245                 250                 255


Gln Trp Lys Gln Thr Asn Phe Met Thr Lys Leu Gly Ser Ile Ser Cys 
            260                 265                 270


Lys Ser Leu Lys Gly Gly Asn Ile Ser 
        275                 280


<210>  1764
<211>  2816
<212>  DNA
<213>  Homo sapiens

<400>  1764
aaacccgccc ctcagcaggc ctgtgctgtg cgctcctctc ccggggacca ccgtcctcag     60

atctccccag ggaatgggtc gtcctcttcc tgcccccacc cgcgagacgc ggcagaaaag    120

cccgcggcta tcttcccgcc agcaacagcc tcccgccgag ccggccggga cagaggcggc    180

ccccaccccc actgggcagg ggactgcaga cggcgctccc cgactctcaa gacgaccagg    240

gagcttccct tttcctcagc ggggtgaggg gcatctgtcg cccgccgact tggaggtgga    300

ggggcaggga cattccctcg ccatcacctc aggagctaga acgcgccctt ctcgcagcag    360

ggcgtgggcc tcccaatccc tccaaggggc ggacggcgtg cgcaaccccc tggagaagca    420

acaggcgccc ccatccccct ccaagccggg taacgccgac cccctcgtcc ctcccgctct    480

tcacctccgg aagccgggcc aaagcctggg cgaacgactg cgcctcactc cgccccctgc    540

gccattttat cgccccctcc ccgacctccc ctaccccgag tcagccgggc caacaccagg    600

gggagggcaa accagcagtg attggcagga aaccgtcccg cctctaggag ggttgtgccc    660

cgctcaggcg cctcagcccc gccctccgca ccgcccaccg tgcccactgg ctccaccttt    720

tcccgtctca tcgacctgct cgactctctg ctgctcctca ctttttccgg ccgctgccgg    780

aggggtccag gccgagtaag cggagcgccg agcccagctg atgcaacctg gctggactcg    840

cgtgacagtt cccggcacgc ggcggcgacg gtgacccagg aaggggctct ggtgccgggc    900

tgagcggggg aagcaggggt agcggagcca tgggggacgc tcccagccct gaagagaaac    960

tgcaccttat cacccggaac ctgcaggagg ttctggggga agagaagctg aaggagatac   1020

tgaaggagcg ggaacttaaa atttactggg gaacggcaac cacgggcaaa ccacatgtgg   1080

cttactttgt gcccatgtca aagattgcag acttcttaaa ggcagggtgt gaggtaacaa   1140

ttctgtttgc ggacctccac gcatacctgg ataacatgaa agccccatgg gaacttctag   1200

aactccgagt cagttactat gagaatgtga tcaaagcaat gctggagagc attggtgtgc   1260

ccttggagaa gctcaagttc atcaaaggca ctgattacca gctcagcaaa gagtacacac   1320

tagatgtgta cagactctcc tccgtggtca cacagcacga ttccaagaag gctggagctg   1380

aggtggtaaa gcaggtggag caccctttgc tgagtggcct cttatacccc ggactgcagg   1440

ctttggatga agagtattta aaagtagatg cccaatttgg aggcattgat cagagaaaga   1500

ttttcacctt tgcagagaag tacctccctg cacttggcta ttcaaaacgg gtccatctga   1560

tgaatcctat ggttccagga ttaacaggca gcaaaatgag ctcttcagaa gaggagtcca   1620

agattgatct ccttgatcgg aaggaggatg tgaagaaaaa actgaagaag gccttctgtg   1680

agccaggaaa tgtggagaac aatggggttc tgtccttcat caagcatgtc ctttttcccc   1740

ttaagtccga gtttgtgatc ctacgagatg agaaatgggg tggaaacaaa acctacacag   1800

cttacgtgga cctggaaaag gactttgctg ctgaggttgt acatcctgga gacctgaaga   1860

attctgttga agtcgcactg aacaagttgc tggatccaat ccgggaaaag tttaataccc   1920

ctgccctgaa aaaactggcc agcgctgcct acccagatcc ctcaaagcag aagccaatgg   1980

ccaaaggccc tgccaagaat tcagaaccag aggaggtcat cccatcccgg ctggatatcc   2040

gtgtggggaa aatcatcact gtggagaagc acccagatgc agacagcctg tatgtagaga   2100

agattgacgt gggggaagct gaaccacgga ctgtggtgag cggcctggta cagttcgtgc   2160

ccaaggagga actgcaggac aggctggtag tggtgctgtg caacctgaaa ccccagaaga   2220

tgagaggagt cgagtcccaa ggcatgcttc tgtgtgcttc tatagaaggg ataaaccgcc   2280

aggttgaacc tctggaccct ccggcaggct ctgctcctgg tgagcacgtg tttgtgaagg   2340

gctatgaaaa gggccaacca gatgaggagc tcaagcccaa gaagaaagtc ttcgagaagt   2400

tgcaggctga cttcaaaatt tctgaggagt gcatcgcaca gtggaagcaa accaacttca   2460

tgaccaagct gggctccatt tcctgtaaat cgctgaaagg ggggaacatt agctagccag   2520

cccagcatct tccccccttc ttccaccact gagtcatctg ctgtctcttc agtctgctcc   2580

atccatcacc catttaccca tctctcagga cacggaagca gcgggtttgg actctttatt   2640

cggtgcagaa ctcggcaagg ggcagcttac cctccccaga acccaggatc atcctgtctg   2700

gctgcagtga gagaccaacc cctaacaagg gctgggccac agcagggagt ccagccctac   2760

cttcttccct tggcagctgg agaaatctgg tttcaatata actcatttaa aaattt       2816


<210>  1765
<211>  528
<212>  PRT
<213>  Homo sapiens

<400>  1765

Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg 
1               5                   10                  15


Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys 
            20                  25                  30


Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro 
        35                  40                  45


His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys 
    50                  55                  60


Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu 
65                  70                  75                  80


Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr 
                85                  90                  95


Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu 
            100                 105                 110


Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu 
        115                 120                 125


Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp 
    130                 135                 140


Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu 
145                 150                 155                 160


Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr 
                165                 170                 175


Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe 
            180                 185                 190


Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val 
        195                 200                 205


His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser 
    210                 215                 220


Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp 
225                 230                 235                 240


Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu 
                245                 250                 255


Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys 
            260                 265                 270


Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr 
        275                 280                 285


Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val 
    290                 295                 300


His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu 
305                 310                 315                 320


Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu 
                325                 330                 335


Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys 
            340                 345                 350


Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu 
        355                 360                 365


Asp Ile Arg Val Gly Lys Ile Ile Thr Val Glu Lys His Pro Asp Ala 
    370                 375                 380


Asp Ser Leu Tyr Val Glu Lys Ile Asp Val Gly Glu Ala Glu Pro Arg 
385                 390                 395                 400


Thr Val Val Ser Gly Leu Val Gln Phe Val Pro Lys Glu Glu Leu Gln 
                405                 410                 415


Asp Arg Leu Val Val Val Leu Cys Asn Leu Lys Pro Gln Lys Met Arg 
            420                 425                 430


Gly Val Glu Ser Gln Gly Met Leu Leu Cys Ala Ser Ile Glu Gly Ile 
        435                 440                 445


Asn Arg Gln Val Glu Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro Gly 
    450                 455                 460


Glu His Val Phe Val Lys Gly Tyr Glu Lys Gly Gln Pro Asp Glu Glu 
465                 470                 475                 480


Leu Lys Pro Lys Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Lys 
                485                 490                 495


Ile Ser Glu Glu Cys Ile Ala Gln Trp Lys Gln Thr Asn Phe Met Thr 
            500                 505                 510


Lys Leu Gly Ser Ile Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile Ser 
        515                 520                 525


<210>  1766
<211>  1059
<212>  DNA
<213>  Homo sapiens

<400>  1766
gaacaatggg gttctgtcct tcatcaagca tgtccttttt ccccttaagt ccggtaacac     60

tctctgtttt cttcctagag gccaggctag aatagaaaag ttcgtgctgt gatcatactt    120

gtgatttgtc acagactctt ccttcaggga ctggctgccc tgattctctg ctctgatttc    180

ttatatatta aagtatgaat gatgttggga tgtaatttaa ttgtccatat attcgttacc    240

aggctaggtt ctgagggaat actggagtgg gcagaggtgt tagaagtaag ggtgggggca    300

gacatgttga actagaggaa tacaacaaaa tagatataag ccacaagcct tcccctgaag    360

cagctgagat gctagctggg tatacaatag tgccactcat ccaatttaag aataatacca    420

tacaataaag ttcagaatat atggcaaaaa ctacaaatag tcatgcatgt gggctaggaa    480

tagtcatgca tgtgagctag gaatgctgtc aatgagtttg ttgacatgga tccttttcct    540

tatagagttt gtgatcctac gagatgagaa atggggtgga aacaaaacct acacagctta    600

cgtggacctg gaaaaggact ttgctgctga ggttgtacat cctggagacc tgaagaattc    660

tgttgaagtc gcactgaaca agttgctgga tccaatccgg gaaaagttta atacccctgc    720

cctgaaaaaa ctggccagcg ctgcctaccc agatccctca aagcagaagc caatggccaa    780

aggccctgcc aagaattcag aaccagagga ggtcatccca tcccggctgg atatccgtgt    840

ggggaaaatc atcactgtgg agaagcaccc agatgcagac agcctgtatg tagagaagat    900

tgacgtgggg gaagctgaac cacggactgt ggtgagcggc ctggtacagt tcgtgcccaa    960

ggaggaactg caggacaggc tggtagtggt gctgtgcaac ctgaaacccc agaagatgag   1020

aggagtcgag tcccaaggca tgcttctgtg tgcttctat                          1059


<210>  1767
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  1767

Met Trp Ala Arg Asn Ser His Ala Cys Glu Leu Gly Met Leu Ser Met 
1               5                   10                  15


Ser Leu Leu Thr Trp Ile Leu Phe Leu Ile Glu Phe Val Ile Leu Arg 
            20                  25                  30


Asp Glu Lys Trp Gly Gly Asn Lys Thr Tyr Thr Ala Tyr Val Asp Leu 
        35                  40                  45


Glu Lys Asp Phe Ala Ala Glu Val Val His Pro Gly Asp Leu Lys Asn 
    50                  55                  60


Ser Val Glu Val Ala Leu Asn Lys Leu Leu Asp Pro Ile Arg Glu Lys 
65                  70                  75                  80


Phe Asn Thr Pro Ala Leu Lys Lys Leu Ala Ser Ala Ala Tyr Pro Asp 
                85                  90                  95


Pro Ser Lys Gln Lys Pro Met Ala Lys Gly Pro Ala Lys Asn Ser Glu 
            100                 105                 110


Pro Glu Glu Val Ile Pro Ser Arg Leu Asp Ile Arg Val Gly Lys Ile 
        115                 120                 125


Ile Thr Val Glu Lys His Pro Asp Ala Asp Ser Leu Tyr Val Glu Lys 
    130                 135                 140


Ile Asp Val Gly Glu Ala Glu Pro Arg Thr Val Val Ser Gly Leu Val 
145                 150                 155                 160


Gln Phe Val Pro Lys Glu Glu Leu Gln Asp Arg Leu Val Val Val Leu 
                165                 170                 175


Cys Asn Leu Lys Pro Gln Lys Met Arg Gly Val Glu Ser Gln Gly Met 
            180                 185                 190


Leu Leu Cys Ala 
        195


<210>  1768
<211>  1120
<212>  DNA
<213>  Homo sapiens

<400>  1768
tgggcagggg actgcagacg gcgctccccg actctcaaga cgaccaggga gcttcccttt     60

tcctcagcgg ggtgaggggc atctgtcgcc cgccgacttg gaggtggagg ggcagggaca    120

ttccctcgcc atcacctcag gagctagaac gcgcccttct cgcagcaggg cgtgggcctc    180

ccaatccctc caaggggcgg acggcgtgcg caaccccctg gagaagcaac aggcgccccc    240

atccccctcc aagccgggta acgccgaccc cctcgtccct cccgctcttc acctccggaa    300

gccgggccaa agcctgggcg aacgactgcg cctcactccg ccccctgcgc cattttatcg    360

ccccctcccc gacctcccct accccgagtc agccgggcca acaccagggg gagggcaaac    420

cagcagtgat tggcaggaaa ccgtcccgcc tctaggaggg ttgtgccccg ctcaggcgcc    480

tcagccccgc cctccgcacc gcccaccgtg cccactggct ccaccttttc ccgtctcatc    540

gacctgctcg actctctgct gctcctcact ttttccggcc gctgccggag gggtccaggc    600

cgagtaagcg gagcgccgag cccagctgat gcaacctggc tggactcgcg tgacagttcc    660

cggcacgcgg cggcgacggt gacccaggaa ggggctctgg tgccgggctg agcgggggaa    720

gcaggggtag cggagccatg ggggacgctc ccagccctga agagaaactg caccttatca    780

cccggaacct gcaggaggtt ctgggggaag agaagctgaa ggagatactg aaggagcggg    840

aacttaaaat ttactgggga acggcaacca cgggcaaacc acatgtggct tactttgtgc    900

ccatgtcaaa gattgcagac ttcttaaagg cagggtgtga ggtaacaatt ctgtttgcgg    960

acctccacgc atacctggat aacatgaaag ccccatggga acttctagaa ctccgagtca   1020

gttactatga gaattttgtg atcctacgag atgagaaatg gggtggaaac aaaacctaca   1080

cagcttacgt ggacctggaa aaggactttg ctgctgaggt                         1120


<210>  1769
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  1769

Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg 
1               5                   10                  15


Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys 
            20                  25                  30


Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro 
        35                  40                  45


His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys 
    50                  55                  60


Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu 
65                  70                  75                  80


Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr 
                85                  90                  95


Tyr Glu Asn Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys 
            100                 105                 110


Thr Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala 
        115                 120                 125


<210>  1770
<211>  953
<212>  DNA
<213>  Homo sapiens

<400>  1770
gctagatttt cttttatact ttggtttaga aaggggagga ggagcctagc tgaagcaatc     60

ttacagaagt aaaacaggca aaaaagttag aaagacaaat ggttacggga aaacaaacag    120

ttccgggcgc aggggcttta aatccatcac aaggtgatag acgcggaggc tttgggtacc    180

atcaaccaga cacaaatgct ggggcttagg gtaatatcaa ctgggcaaat tcctgggaac    240

tgcggctata gctttccaca atatcttatc agttatttgc gttctttgat gtgctgggag    300

tcagcttgca caagttaagt ccttgaggaa ggggggtggg taagaggctg caaggggcta    360

caagtgaagg agccaaaatg gagtttgtct ggctctctca gctaagggag agtcaattca    420

gattaaaaca aggtagggta tcacatctgc actgagaaca tggctggacc tccttgatgg    480

ctctgagcct ggatctccac tgacacatgc tgttgttttc cttgtcacat ggtaaaggat    540

gagcaaggtg aggcactgac attaaactaa ctcttctgct tccacaatag gaggttctgg    600

gggaagagaa gctgaaggag atactgaagg agcgggaact taaaatttac tggggaacgg    660

caaccacggg caaaccacat gtggcttact ttgtgcccat gtcaaagatt gcagacttct    720

taaaggcagg gtgtgaggta acaattctgt ttgcggacct ccacgcatac ctggataaca    780

tgaaagcccc atgggaactt ctagaactcc gagtcagtta ctatgagaat gtgatcaaag    840

caatgctgga gagcattggt gtgcccttgg agaagctcaa gttcatcaaa ggcactgatt    900

accagctcag caaagagtac acactagatg tgtacagact ctcctccgtg gtc           953


<210>  1771
<211>  84
<212>  PRT
<213>  Homo sapiens

<400>  1771

Met Ser Lys Ile Ala Asp Phe Leu Lys Ala Gly Cys Glu Val Thr Ile 
1               5                   10                  15


Leu Phe Ala Asp Leu His Ala Tyr Leu Asp Asn Met Lys Ala Pro Trp 
            20                  25                  30


Glu Leu Leu Glu Leu Arg Val Ser Tyr Tyr Glu Asn Val Ile Lys Ala 
        35                  40                  45


Met Leu Glu Ser Ile Gly Val Pro Leu Glu Lys Leu Lys Phe Ile Lys 
    50                  55                  60


Gly Thr Asp Tyr Gln Leu Ser Lys Glu Tyr Thr Leu Asp Val Tyr Arg 
65                  70                  75                  80


Leu Ser Ser Val 



<210>  1772
<211>  498
<212>  DNA
<213>  Homo sapiens

<400>  1772
tgtggggccg gggactcggc gctggcgcag ctctgagaga gcctgtagat ctcactgctg     60

gtcggtcagt caatcaagca gcccttccct gggttcccca gaaatcacag tgggctcacc    120

tcttgcgtcc agttgtcttg tgttggagcc aaactttgaa tccaggactc ccattccacc    180

cccctattaa gtgccagacg tggtgcttag tcgctgggga tacgtcaagg gcctgccaga    240

gcttgtctga aggggatcag acgttaaaaa tgacccatta cggttcaaga ggttctgggg    300

gaagagaagc tgaaggagat actgaaggag cgggaactta aaatttactg gggaacggca    360

accacgggca aaccacatgt ggcttacttt gtgcccatgt caaagattgc agacttctta    420

aaggcagggt gtgaggtaac aattctgttt gcggacctcc acgcatacct ggataacatg    480

aaagccccat gggaactt                                                  498


<210>  1773
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  1773

Met Ser Lys Ile Ala Asp Phe Leu Lys Ala Gly Cys Glu Val Thr Ile 
1               5                   10                  15


Leu Phe Ala Asp Leu His Ala Tyr Leu Asp Asn Met Lys Ala Pro Trp 
            20                  25                  30


Glu 



<210>  1774
<211>  773
<212>  DNA
<213>  Homo sapiens

<400>  1774
gctagatttt cttttatact ttggtttaga aaggggagga ggagcctagc tgaagcaatc     60

ttacagaagt aaaacaggca aaaaagttag aaagacaaat ggttacggga aaacaaacag    120

ttccgggcgc aggggcttta aatccatcac aaggtgatag acgcggaggc tttgggtacc    180

atcaaccaga cacaaatgct ggggcttagg gtaatatcaa ctgggcaaat tcctgggaac    240

tgcggctata gctttccaca atatcttatc agttatttgc gttctttgat gtgctgggag    300

tcagcttgca caagttaagt ccttgaggaa ggggggtggg taagaggctg caaggggcta    360

caagtgaagg agccaaaatg gagtttgtct ggctctctca gctaagggag agtcaattca    420

gattaaaaca aggtagggta tcacatctgc actgagaaca tggctggacc tccttgatgg    480

ctctgagcct ggatctccac tgacacatgc tgttgttttc cttgtcacat ggtaaaggat    540

gagcaaggtg aggcactgac attaaactaa ctcttctgct tccacaatag gaggttctgg    600

gggaagagaa gctgaaggag atactgaagg agcgggaact taaaatttac tggggaacgg    660

caaccacggg caaaccacat gtggcttact ttgtgcccat gtcaaagatt gcagacttct    720

taaaggcagg gtgtgaggta acaattctgt ttgcggacct ccacgcatac ctg           773


<210>  1775
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  1775

Met Leu Gly Leu Arg Val Ile Ser Thr Gly Gln Ile Pro Gly Asn Cys 
1               5                   10                  15


Gly Tyr Ser Phe Pro Gln Tyr Leu Ile Ser Tyr Leu Arg Ser Leu Met 
            20                  25                  30


Cys Trp Glu Ser Ala Cys Thr Ser 
        35                  40


<210>  1776
<211>  4344
<212>  DNA
<213>  Homo sapiens

<400>  1776
gatgagacgg gaaaaggtgg agccagtggg cacggtgggc ggtgcggagg gcggggctga     60

ggcgcctgag cggggcacaa ccctcctaga ggcgggacgg tttcctgcca atcactgctg    120

gtttgccctc cccctggtgt tggcccggct gactcgggga aggtgggagt caatcatttt    180

gacaagtctc ctgaaaggaa cagctagcag gaactgaaac ctttttccat ttggtctcgt    240

ggcaaaggca gagattgctc cagcagctcc acacaaaatg atgtgctcac gggtgccctc    300

tgaacagtct tctggtacct ctctcttgcc taaagacggt gccccatttt cttgggattc    360

cttggatgag gatggattgg atgactcctt gctggagctg tcagagggag aagaagatga    420

tggtgatgta aattacacag aggaagagat tgatgcactg ttgaaggaag atgacccatc    480

atatgagcag tcttctgggg aagatgatgg tgggcatgtt gagaagggag aaagagggag    540

tcaaattcta cttgatactc cccgagagaa aaattcatcg tacagcctgg gaccagtagc    600

tgagactcct gacctcttca aactacctca gctaagtaca tcaagtggtc atggaccagc    660

tcatactaaa ccattaaaca gacgctctgt actagaaaag aatcttataa aagtaactgt    720

tgcaccattt aatccaacag tttgtgatgc tctgcttgat aaggacgaga ctgattcgtc    780

caaagatact gaaaaactct cttcccttgg agaagagatg agagaagatg gtcttagccc    840

aaatgaaagc aaactttgta ctgaatctga agggatcagc cccaataact ctgcctggaa    900

tgggccccag ctctcttctt caaacaataa ctttcaacag actgtctctg ataaaaatat    960

gcctgacagt gagaacccta cgtctgtatt ctctcggatc tcagaccatt cagagactcc   1020

taatatggag ttatcctgca gaaatggtgg ttcacacaag tcaagttgtg aaatgagatc   1080

tctggttgtt tccacctcat caaacaaaca ggatgttctt aacaaggatt ctgggaagat   1140

gaaaggccat gagagaagac taggcaaagt cattcctgtt ctacaaacta agaccaggac   1200

taatgttccg acgttttcac agtcaaatct agaacagcag aagcagcttt atctcaggag   1260

tgtcattgct catatagaag acccagagga cactaaccaa ggtatctcgg gggagctttg   1320

tgccttgatg gatcaagttc atcatatgca gcactcaaaa tggcagcatc cttcggacct   1380

caccacgcga aactacgccc gccgacagaa acatctgcaa agatacagtc tgactcagtg   1440

ggttgacagg aacatgcgaa gccaccatcg gttccagcgt ctcccagact tctcgtacag   1500

ttaatttgtg tcatcccatc agcaatgaag gtccctatcc agggtcctgc ttggagcagc   1560

atttcatgtt cttttgctgt tttgtgcttt gccgattttg gattttattt ttcacaaaat   1620

ttttatttaa aaaactcgtc accttttgga aatgcccatt gccgacttga atttttttgt   1680

atgaagtccc tcctgatttt gtgtgtgtgt gtctgtgttt aagcaagcgt tcggttggta   1740

tagttttttt ttgttttttt aatttaaatt gaaggtagct gcctcctgaa agccagcatt   1800

aagccagaac acccaggttc aagcaaaaga cccacctctc tgcagaggca aagtctactt   1860

tctggtacct caaagaaatc attgttcaat cttccataag gaagagattc tttaccaggc   1920

tgtgagccag tgttagataa cttgtgaatg gatataagtt acttttaaca acccctctta   1980

cttttttatt tgaatcctct gaatacctgt cagtatttta aagttggcaa tccaggacat   2040

tataagtagg atggagcagg agaagaatcc tattgaaagg acaaattaaa atagtaaatc   2100

ctctcctctc ccttctgtag gtactagctg ccttgatttt tttttgtggg tgggggggat   2160

tttttcattc cttattgaac ttattttgca caatagtgtt tacaaatctt atacatctta   2220

ctttgacaga agacttataa taccttgtgg tcttgagact ggttgtctcc tttgcctttc   2280

ttcaaggatt ttcctttttc tttttacccc ccagtgacca ctctgctctt taggattcta   2340

gtggcagtat tcttgtaacc tgttagacgt ggatatacct cttcaggatg gcctccttgc   2400

tgtctttatt gaagagctgc ccacccagag tcttgactct agggcaggct agtgctattg   2460

tggtgtcagt tgatatttag tttcatttgc tgaaccccaa atttgagtgt tagttaggga   2520

gcctccattc tgtgggagag tgtggaaagg cactcttttt tctccatatt agttaacaag   2580

aggtgtcttt aggccctgga tgttaccatc tcatttggtc aagcccctga tacctagttt   2640

cacatggatg ctaacgtgga tgtaatatag ttgtgacagc ctatgcacaa aagcattacc   2700

tgatcttaag gtttggtatt ctaaccaaag ttgacagact gtgcgtctgt cttaatggat   2760

gtcttaggag ttggttattc tctctttttt ttttgagacg gagtttcgct gttgttgccc   2820

aggctggagt gcaatggcgt atctccactc accacaacct ccgcctcctg ggttcaaggg   2880

attctcctgt cttagcctcc tgagtagctg tgattacagg catgcgccac catgcctggc   2940

taatttcata ttttttagta gagacaggat ttctccatgt tggtcaggct ggtcttgaac   3000

tcctgacctc aggtgatctg cccacctcgg cctcctaaag tgctgggatt acaggcatga   3060

gccactgcac ctggccggtt attctctctt tacagatagc tatagacatc attttaggaa   3120

gtgttgcagt ctggcatttg tgctattgtt cattctctgt gaaggctgtt catagttgct   3180

atagcctgtg tttagttttg tgatttcatc aatcccatct ttctgtgtga gtaatgcatt   3240

ctaaacatcc taccccactt tagaaacgga cgtggggaac gcttggtcat ttaagccaac   3300

aataaattta ggtgaatgtc cctaagtgtt tactgttttt atccagtcaa ggatttgctt   3360

ttccttgaac atttgtttta aattctgggg ccaaaatgca aaggagaagt tctattcaaa   3420

ggcagtagtt gaaatctatt attttagtta gcctacttgg catttactac atcggtcact   3480

tctccaggct gccctaaatt aggttgatgg agtgagacat gccaaacatc cacctttggg   3540

accatagcat agttaaaatt aaatgtagtt ggaatagcta gcattgcagc tacagtaggg   3600

aactgtagtc tagttcccta cagaaaaccc aaggagtgaa gggacaggat tttgcctagg   3660

caaaaatcta agactcgtgc cctcctggta catggggttt taagactgaa tgtgtaatag   3720

gagcactgcc tttgccaaat caaatgagtg acaggttaac tagaaaatgt gacaatcaca   3780

tttcctctta gctcaaataa ttctgttttt ccaaagcttt agcagcttaa ttaaatctgt   3840

tggactgggg gaggagagag ctgttctcta gtggttaaca tggtattctt taagaagaaa   3900

aaacaaagcc aaagaaaact cattatctgg catgttcgcc ttaaagatgg tactgggtag   3960

aatctggagt tttcatctct tttcaaagct gcatatctct tatatttggt attggcctct   4020

aagtctaata ttgcagttgg aattcttgct gtattatttt ttaagcaagt gttaggtgca   4080

tttaactgct ttcttcatcc atgacgacat tcccaccatg ggggtcttga caaagcagag   4140

taaaaatatg ctgtttacat tgtttactta caagtaagga gcctgaaata acctgtagtt   4200

tcgaatgcag gccctgattt actggcgttg tcagtttcaa ttatgaaact gaagtttggt   4260

gcctcctctt tatcatgttt tttcccttgt agcagttgtg tttaatgtca ttaaaaagaa   4320

ataaaagttc tttgtcagtg acat                                          4344


<210>  1777
<211>  408
<212>  PRT
<213>  Homo sapiens

<400>  1777

Met Met Cys Ser Arg Val Pro Ser Glu Gln Ser Ser Gly Thr Ser Leu 
1               5                   10                  15


Leu Pro Lys Asp Gly Ala Pro Phe Ser Trp Asp Ser Leu Asp Glu Asp 
            20                  25                  30


Gly Leu Asp Asp Ser Leu Leu Glu Leu Ser Glu Gly Glu Glu Asp Asp 
        35                  40                  45


Gly Asp Val Asn Tyr Thr Glu Glu Glu Ile Asp Ala Leu Leu Lys Glu 
    50                  55                  60


Asp Asp Pro Ser Tyr Glu Gln Ser Ser Gly Glu Asp Asp Gly Gly His 
65                  70                  75                  80


Val Glu Lys Gly Glu Arg Gly Ser Gln Ile Leu Leu Asp Thr Pro Arg 
                85                  90                  95


Glu Lys Asn Ser Ser Tyr Ser Leu Gly Pro Val Ala Glu Thr Pro Asp 
            100                 105                 110


Leu Phe Lys Leu Pro Gln Leu Ser Thr Ser Ser Gly His Gly Pro Ala 
        115                 120                 125


His Thr Lys Pro Leu Asn Arg Arg Ser Val Leu Glu Lys Asn Leu Ile 
    130                 135                 140


Lys Val Thr Val Ala Pro Phe Asn Pro Thr Val Cys Asp Ala Leu Leu 
145                 150                 155                 160


Asp Lys Asp Glu Thr Asp Ser Ser Lys Asp Thr Glu Lys Leu Ser Ser 
                165                 170                 175


Leu Gly Glu Glu Met Arg Glu Asp Gly Leu Ser Pro Asn Glu Ser Lys 
            180                 185                 190


Leu Cys Thr Glu Ser Glu Gly Ile Ser Pro Asn Asn Ser Ala Trp Asn 
        195                 200                 205


Gly Pro Gln Leu Ser Ser Ser Asn Asn Asn Phe Gln Gln Thr Val Ser 
    210                 215                 220


Asp Lys Asn Met Pro Asp Ser Glu Asn Pro Thr Ser Val Phe Ser Arg 
225                 230                 235                 240


Ile Ser Asp His Ser Glu Thr Pro Asn Met Glu Leu Ser Cys Arg Asn 
                245                 250                 255


Gly Gly Ser His Lys Ser Ser Cys Glu Met Arg Ser Leu Val Val Ser 
            260                 265                 270


Thr Ser Ser Asn Lys Gln Asp Val Leu Asn Lys Asp Ser Gly Lys Met 
        275                 280                 285


Lys Gly His Glu Arg Arg Leu Gly Lys Val Ile Pro Val Leu Gln Thr 
    290                 295                 300


Lys Thr Arg Thr Asn Val Pro Thr Phe Ser Gln Ser Asn Leu Glu Gln 
305                 310                 315                 320


Gln Lys Gln Leu Tyr Leu Arg Ser Val Ile Ala His Ile Glu Asp Pro 
                325                 330                 335


Glu Asp Thr Asn Gln Gly Ile Ser Gly Glu Leu Cys Ala Leu Met Asp 
            340                 345                 350


Gln Val His His Met Gln His Ser Lys Trp Gln His Pro Ser Asp Leu 
        355                 360                 365


Thr Thr Arg Asn Tyr Ala Arg Arg Gln Lys His Leu Gln Arg Tyr Ser 
    370                 375                 380


Leu Thr Gln Trp Val Asp Arg Asn Met Arg Ser His His Arg Phe Gln 
385                 390                 395                 400


Arg Leu Pro Asp Phe Ser Tyr Ser 
                405


<210>  1778
<211>  3636
<212>  DNA
<213>  Homo sapiens

<400>  1778
acaaccctcc tagaggcggg acggtttcct gccaatcact gctggtttgc cctccccctg     60

gtgttggccc ggctgactcg gggtagggga ggtcggggag ggggcgataa aatggcgcag    120

ggggcggagt gaggcgcagt cgttcgccca ggctttggcc cggcttccgg aggaaggtgg    180

gagtcaatca ttttgacaag tctcctgaaa ggaacagcta gcaggaactg aaaccttttt    240

ccatttggtc tcgtggcaaa ggcagagatt gctccagcag ctccacacaa aatgatgtgc    300

tcacgggtgc cctctgaaca gtcttctggt acctctctct tgcctaaaga cggtgcccca    360

ttttcttggg attccttgga tgaggatgga ttggatgact ccttgctgga gctgtcagag    420

ggagaagaag atgatggtga tgtaaattac acagaggaag agattgatgc actgttgaag    480

gaagatgacc catcatatga gcagtcttct ggggaagatg atggtgggca tgttgagaag    540

ggagaaagag ggagtcaaat tctacttgat actccccgag agaaaaattc atcgtacagc    600

ctgggaccag tagctgagac tcctgacctc ttcaaactac ctcagctaag tacatcaagt    660

ggtcatggac cagctcatac taaaccatta aacagacgct ctgtactaga aaagaatctt    720

ataaaagtaa ctgttgcacc atttaatcca acagtttgtg atgctctgct tgataaggac    780

gagactgatt cgtccaaaga tactgaaaaa ctctcttccc ttggagaaga gatgagagaa    840

gatggtctta gcccaaatga aagcaaactt tgtactgaat ctgaagggat cagccccaat    900

aactctgcct ggaatgggcc ccagctctct tcttcaaaca ataactttca acagactgtc    960

tctgataaaa atatgcctga cagtgagaac cctacgtctg tattctctcg gatctcagac   1020

cattcagaga ctcctaatat ggagttatcc tgcagaaatg gtggttcaca caagtcaagt   1080

tgtgaaatga gatctctggt tgtttccacc tcatcaaaca aacaggatgt tcttaacaag   1140

gattctggga agatgaaagg ccatgagaga agactaggca aagtcattcc tgttctacaa   1200

actaagacca ggactaatgt tccgacgttt tcacagtcaa atctagaaca gcagaagcag   1260

ctttatctca ggagtgtcat tgctcatata gaagacccag aggacactaa ccaaggatga   1320

atccctagaa gtggaattgc tgggcgcagt ggctcatgcc tgtaatccca gcactttggg   1380

aggctgaggc agatggatca tctgaggtca ggagttcaag accagcctga ctaacatgat   1440

gaaacctgtc tctactaaaa atataaaaat tagctgggcg tggtggtggg cgcctgtaat   1500

cccagctact cgggaggctg aggcaggaga atctcttgaa cccaagaggc agaagttgta   1560

gtgagcgaag atcaggccat tgcactccag cctgggcaac gagcaaaatt ccatctcaaa   1620

agaaaaaaat gttcattttc taaatatata atttcttcta cagttattaa ctagcattct   1680

tttgtaaaga ttttctatta ctttactatt actataacct catggatttt tttaaagaat   1740

caatatgttg taatcaatta tagctactgt tcttggtttt tctttttgat gctcaatttg   1800

tctcaaattt gataaatggg agctccttca agatgactct tgttcctatt gacatgatcc   1860

cattaatctt tttttttaat tgtggtaaaa aaaatacatc taacataaaa ttaccatctt   1920

aaccattttt aagtgcacaa ttcagtaatg ttacatatat tcacattgtt gtgaaacata   1980

tctccagaac ctcttcatct tgcaaatcta aaactctata cctacacaac agttccccct   2040

ctctcccttc agtctctggt aaccaccatt ctactttctt tttttttaaa tatgactact   2100

ttagatacct tttataagtg gaatcataca atatttatct ttttgtgact ggcttatttc   2160

gtttagtata atgtcttcaa gatttaccca ttgtggcatg tgacaggatt tccttccttt   2220

ttaaatattt ttatttttat tttttttcta tttttctcac cactcaattt ccttcctttt   2280

taaggctgaa taatattcca ttgtatatat acacaccatt ttgtttaatc cattcatctg   2340

tcagtagaca tttgggttgc ttccacttct tggctattgt gaattgtgcc actatgaaca   2400

tgggtctaca gatatctctt taagacccta tttttaattc ttctggatat atatgcagaa   2460

gtgggattgc tggaccatat ggtaggtctg tttttaattt tttgaggaac ttcatactgt   2520

ttttcatagc agttgcacca ttttgcagtc ctaccaacag tgcacaagag ttctaatttt   2580

tccccatcct tgccagcact tatttttttg tgcttttttt ttttttttga ggctggagtc   2640

tcgccctgtc atccaggctg gagtgcagtg gtacagtctt ggctcactgc aacccctacc   2700

tcccacattc aagtgattct cgtgcctcag cctcccaagt agctgggact acaggcgcac   2760

tccaccacgt ctggctaatt tttgtatttt agtagagatg gggttttgcc atgttggtca   2820

ggctggtctc gaactcctga gctcaagtga tctccccatc tcggcctccc aaagtgctgg   2880

gattgcaggt gtgaaccact gtgcctggct tgtgtttttg tttttgtttg ttttttttta   2940

tagtagctat cctaaagggt gttaaatcag tattcattgt ttttgtgtcc caactaagta   3000

ttgttcactg aaaagccaag tagtatatta tggcttcatt ttctttcttg aattgtttat   3060

ttttgtagag ttgttaattg cttcagtttc tttcattaaa tttttttttt gggagagctt   3120

tttcctagag ccttctgttc tactgctcca atttgcactg cttgttcttt agccctgcaa   3180

cagagctgtc atcccaggat tttcctctgc tgccctcctg ggttgaatcc tgtttcttgg   3240

atcctatatc ttcctctttc ttatttttgg ttttagtaga ggacatcctc tgagaatatc   3300

taagaaaggg tgcatagatg ttttctttgt gtttacatat ctgaacatgt ctttattcta   3360

tcctcatact tgattgatag tttgatataa aattctaaat ttaaaatcaa tttttgctca   3420

gaaatttgaa gacatggcca ggcgcagtgg ctcacgcctg taatcccagc actttgggag   3480

gctgaggtgg gcggatccca aggtcaagag ttcgagacca gtctggccaa tatggtgaaa   3540

ccccatctct actaaaaaaa aaacatacaa aaattagcct ggtgtggtgg cgggtgcctg   3600

tagtccagcc tgggcaacaa aacaagactc catctc                             3636


<210>  1779
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  1779

Met Met Cys Ser Arg Val Pro Ser Glu Gln Ser Ser Gly Thr Ser Leu 
1               5                   10                  15


Leu Pro Lys Asp Gly Ala Pro Phe Ser Trp Asp Ser Leu Asp Glu Asp 
            20                  25                  30


Gly Leu Asp Asp Ser Leu Leu Glu Leu Ser Glu Gly Glu Glu Asp Asp 
        35                  40                  45


Gly Asp Val Asn Tyr Thr Glu Glu Glu Ile Asp Ala Leu Leu Lys Glu 
    50                  55                  60


Asp Asp Pro Ser Tyr Glu Gln Ser Ser Gly Glu Asp Asp Gly Gly His 
65                  70                  75                  80


Val Glu Lys Gly Glu Arg Gly Ser Gln Ile Leu Leu Asp Thr Pro Arg 
                85                  90                  95


Glu Lys Asn Ser Ser Tyr Ser Leu Gly Pro Val Ala Glu Thr Pro Asp 
            100                 105                 110


Leu Phe Lys Leu Pro Gln Leu Ser Thr Ser Ser Gly His Gly Pro Ala 
        115                 120                 125


His Thr Lys Pro Leu Asn Arg Arg Ser Val Leu Glu Lys Asn Leu Ile 
    130                 135                 140


Lys Val Thr Val Ala Pro Phe Asn Pro Thr Val Cys Asp Ala Leu Leu 
145                 150                 155                 160


Asp Lys Asp Glu Thr Asp Ser Ser Lys Asp Thr Glu Lys Leu Ser Ser 
                165                 170                 175


Leu Gly Glu Glu Met Arg Glu Asp Gly Leu Ser Pro Asn Glu Ser Lys 
            180                 185                 190


Leu Cys Thr Glu Ser Glu Gly Ile Ser Pro Asn Asn Ser Ala Trp Asn 
        195                 200                 205


Gly Pro Gln Leu Ser Ser Ser Asn Asn Asn Phe Gln Gln Thr Val Ser 
    210                 215                 220


Asp Lys Asn Met Pro Asp Ser Glu Asn Pro Thr Ser Val Phe Ser Arg 
225                 230                 235                 240


Ile Ser Asp His Ser Glu Thr Pro Asn Met Glu Leu Ser Cys Arg Asn 
                245                 250                 255


Gly Gly Ser His Lys Ser Ser Cys Glu Met Arg Ser Leu Val Val Ser 
            260                 265                 270


Thr Ser Ser Asn Lys Gln Asp Val Leu Asn Lys Asp Ser Gly Lys Met 
        275                 280                 285


Lys Gly His Glu Arg Arg Leu Gly Lys Val Ile Pro Val Leu Gln Thr 
    290                 295                 300


Lys Thr Arg Thr Asn Val Pro Thr Phe Ser Gln Ser Asn Leu Glu Gln 
305                 310                 315                 320


Gln Lys Gln Leu Tyr Leu Arg Ser Val Ile Ala His Ile Glu Asp Pro 
                325                 330                 335


Glu Asp Thr Asn Gln Gly 
            340


<210>  1780
<211>  1748
<212>  DNA
<213>  Homo sapiens

<400>  1780
acaaccctcc tagaggcggg acggtttcct gccaatcact gctggtttgc cctccccctg     60

gtgttggccc ggctgactcg gggtagggga ggtcggggag ggggcgataa aatggcgcag    120

ggggcggagt gaggcgcagt cgttcgccca ggctttggcc cggcttccgg aggaaggtgg    180

gagtcaatca ttttgacaag tctcctgaaa ggaacagcta gcaggaactg aaaccttttt    240

ccatttggtc tcgtggcaaa ggcagagatt gctccagcag ctccacacaa aatgatgtgc    300

tcacgggtgc cctctgaaca gtcttctggt acctctctct tgcctaaaga cggtgcccca    360

ttttcttggg attccttgga tgaggatgga ttggatgact ccttgctgga gctgtcagag    420

ggagaagaag atgatggtga tgtaaattac acagaggaag agattgatgc actgttgaag    480

gaagatgacc catcatatga gcagtcttct ggggaagatg atggtgggca tgttgagaag    540

ggagaaagag ggagtcaaat tctacttgat actccccgag agaaaaattc atcgtacagc    600

ctgggaccag tagctgagac tcctgacctc ttcaaactac ctcagctaag tacatcaagt    660

ggtcatggac cagctcatac taaaccatta aacagacgct ctgtactaga aaagaatctt    720

ataaaagtaa ctgttgcacc atttaatcca acagtttgtg atgctctgct tgataaggac    780

gagactgatt cgtccaaaga tactgaaaaa ctctcttccc ttggagaaga gatgagagaa    840

gatggtctta gcccaaatga aagcaaactt tgtactgaat ctgaagggat cagccccaat    900

aactctgcct ggaatgggcc ccagctctct tcttcaaaca ataactttca acagactgtc    960

tctgataaaa atatgcctga cagtgagaac cctacgtctg tattctctcg gatctcagac   1020

cattcagaga ctcctaatat ggagttatcc tgcagaaatg gtggttcaca caagtcaagt   1080

tgtgaaatga gatctctggt tgtttccacc tcatcaaaca aacaggatgt tcttaacaag   1140

gattctggga agatgaaagg ccatgagaga agactaggca aagtcattcc tgttctacaa   1200

actaagacca ggactaatgt tccgacgttt tcacagtcaa atctagaaca gcagaagcag   1260

ctttatctca ggagtgtcat tgctcatata gaagacccag aggacactaa ccaaggatga   1320

atccctagaa gtggaattgc tggacagggt ttcaccaagt tggccaggct gttctcgagc   1380

tcttgacttc aagtgatcag ccctcctcag cctcccaaag tgctgagatt acgggtgtga   1440

gcccccgcgc ctgactgaga attaacattt taatattgag tgttttgatt aaagtcttct   1500

ctaatttcct tcataaatgt tttgtagctt ttgtacagtc ttgcacatct tttatccaat   1560

ttatcccgga gtgtttcata ttgtgatgct tttgtaaaat gatttagttt ttaaaatttc   1620

agtatctgtt cattgctatt atatagaaat gtaattgatt tttgtgtctt ggtcttacat   1680

tctataacct tcctaaattc ttttattagt tttagtaact ttttaataga tttcatcagg   1740

ttttccct                                                            1748


<210>  1781
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  1781

Met Met Cys Ser Arg Val Pro Ser Glu Gln Ser Ser Gly Thr Ser Leu 
1               5                   10                  15


Leu Pro Lys Asp Gly Ala Pro Phe Ser Trp Asp Ser Leu Asp Glu Asp 
            20                  25                  30


Gly Leu Asp Asp Ser Leu Leu Glu Leu Ser Glu Gly Glu Glu Asp Asp 
        35                  40                  45


Gly Asp Val Asn Tyr Thr Glu Glu Glu Ile Asp Ala Leu Leu Lys Glu 
    50                  55                  60


Asp Asp Pro Ser Tyr Glu Gln Ser Ser Gly Glu Asp Asp Gly Gly His 
65                  70                  75                  80


Val Glu Lys Gly Glu Arg Gly Ser Gln Ile Leu Leu Asp Thr Pro Arg 
                85                  90                  95


Glu Lys Asn Ser Ser Tyr Ser Leu Gly Pro Val Ala Glu Thr Pro Asp 
            100                 105                 110


Leu Phe Lys Leu Pro Gln Leu Ser Thr Ser Ser Gly His Gly Pro Ala 
        115                 120                 125


His Thr Lys Pro Leu Asn Arg Arg Ser Val Leu Glu Lys Asn Leu Ile 
    130                 135                 140


Lys Val Thr Val Ala Pro Phe Asn Pro Thr Val Cys Asp Ala Leu Leu 
145                 150                 155                 160


Asp Lys Asp Glu Thr Asp Ser Ser Lys Asp Thr Glu Lys Leu Ser Ser 
                165                 170                 175


Leu Gly Glu Glu Met Arg Glu Asp Gly Leu Ser Pro Asn Glu Ser Lys 
            180                 185                 190


Leu Cys Thr Glu Ser Glu Gly Ile Ser Pro Asn Asn Ser Ala Trp Asn 
        195                 200                 205


Gly Pro Gln Leu Ser Ser Ser Asn Asn Asn Phe Gln Gln Thr Val Ser 
    210                 215                 220


Asp Lys Asn Met Pro Asp Ser Glu Asn Pro Thr Ser Val Phe Ser Arg 
225                 230                 235                 240


Ile Ser Asp His Ser Glu Thr Pro Asn Met Glu Leu Ser Cys Arg Asn 
                245                 250                 255


Gly Gly Ser His Lys Ser Ser Cys Glu Met Arg Ser Leu Val Val Ser 
            260                 265                 270


Thr Ser Ser Asn Lys Gln Asp Val Leu Asn Lys Asp Ser Gly Lys Met 
        275                 280                 285


Lys Gly His Glu Arg Arg Leu Gly Lys Val Ile Pro Val Leu Gln Thr 
    290                 295                 300


Lys Thr Arg Thr Asn Val Pro Thr Phe Ser Gln Ser Asn Leu Glu Gln 
305                 310                 315                 320


Gln Lys Gln Leu Tyr Leu Arg Ser Val Ile Ala His Ile Glu Asp Pro 
                325                 330                 335


Glu Asp Thr Asn Gln Gly 
            340


<210>  1782
<211>  1683
<212>  DNA
<213>  Homo sapiens

<400>  1782
acaaccctcc tagaggcggg acggtttcct gccaatcact gctggtttgc cctccccctg     60

gtgttggccc ggctgactcg gggtagggga ggtcggggag ggggcgataa aatggcgcag    120

ggggcggagt gaggcgcagt cgttcgccca ggctttggcc cggcttccgg aggaaggtgg    180

gagtcaatca ttttgacaag tctcctgaaa ggaacagcta gcaggaactg aaaccttttt    240

ccatttggtc tcgtggcaaa ggcagagatt gctccagcag ctccacacaa aatgatgtgc    300

tcacgggtgc cctctgaaca gtcttctggt acctctctct tgcctaaaga cggtgcccca    360

ttttcttggg attccttgga tgaggatgga ttggatgact ccttgctgga gctgtcagag    420

ggagaagaag atgatggtga tgtaaattac acagaggaag agattgatgc actgttgaag    480

gaagatgacc catcatatga gcagtcttct ggggaagatg atggtgggca tgttgagaag    540

ggagaaagag ggagtcaaat tctacttgat actccccgag agaaaaattc atcgtacagc    600

ctgggaccag tagctgagac tcctgacctc ttcaaactac ctcagctaag tacatcaagt    660

ggtcatggac cagctcatac taaaccatta aacagacgct ctgtactaga aaagaatctt    720

ataaaagtaa ctgttgcacc atttaatcca acagtttgtg atgctctgct tgataaggac    780

gagactgatt cgtccaaaga tactgaaaaa ctctcttccc ttggagaaga gatgagagaa    840

gatggtctta gcccaaatga aagcaaactt tgtactgaat ctgaagggat cagccccaat    900

aactctgcct ggaatgggcc ccagctctct tcttcaaaca ataactttca acagactgtc    960

tctgataaaa atatgcctga cagtgagaac cctacgtctg tattctctcg gatctcagac   1020

cattcagaga ctcctaatat ggagttatcc tgcagaaatg gtggttcaca caagtcaagt   1080

tgtgaaatga gatctctggt tgtttccacc tcatcaaaca aacaggatgt tcttaacaag   1140

gattctggga agatgaaagg ccatgagaga agactaggca aagtcattcc tgttctacaa   1200

actaagacca ggactaatgt tccgacgttt tcacagtcaa atctagaaca gcagaagcag   1260

ctttatctca ggagtgtcat tgctcatata gaagacccag aggacactaa ccaaggtatc   1320

tcgggggagc tttgtgcctt gatggatcaa gttcatcata tgcagcactc aaaatggcag   1380

catccttcgg acctcaccac gcgaaactac gcccgccgac agaaacatct gcaaagatac   1440

agtctgactc agtgggttga caggaacatg cgaagccacc atcggttcca gcgtctccca   1500

gacttctcgt acagttaatt tgtgtcatcc catcagcaat gaaggtccct atccagggtc   1560

ctgcttggag cagcatttca tgttcttttg ctgttttgtg ctttgccgat tttggatttt   1620

atttttcaca aaatttttat ttaaaaaact cgtcaccttt tggaaatgcc cattgccgac   1680

ttg                                                                 1683


<210>  1783
<211>  408
<212>  PRT
<213>  Homo sapiens

<400>  1783

Met Met Cys Ser Arg Val Pro Ser Glu Gln Ser Ser Gly Thr Ser Leu 
1               5                   10                  15


Leu Pro Lys Asp Gly Ala Pro Phe Ser Trp Asp Ser Leu Asp Glu Asp 
            20                  25                  30


Gly Leu Asp Asp Ser Leu Leu Glu Leu Ser Glu Gly Glu Glu Asp Asp 
        35                  40                  45


Gly Asp Val Asn Tyr Thr Glu Glu Glu Ile Asp Ala Leu Leu Lys Glu 
    50                  55                  60


Asp Asp Pro Ser Tyr Glu Gln Ser Ser Gly Glu Asp Asp Gly Gly His 
65                  70                  75                  80


Val Glu Lys Gly Glu Arg Gly Ser Gln Ile Leu Leu Asp Thr Pro Arg 
                85                  90                  95


Glu Lys Asn Ser Ser Tyr Ser Leu Gly Pro Val Ala Glu Thr Pro Asp 
            100                 105                 110


Leu Phe Lys Leu Pro Gln Leu Ser Thr Ser Ser Gly His Gly Pro Ala 
        115                 120                 125


His Thr Lys Pro Leu Asn Arg Arg Ser Val Leu Glu Lys Asn Leu Ile 
    130                 135                 140


Lys Val Thr Val Ala Pro Phe Asn Pro Thr Val Cys Asp Ala Leu Leu 
145                 150                 155                 160


Asp Lys Asp Glu Thr Asp Ser Ser Lys Asp Thr Glu Lys Leu Ser Ser 
                165                 170                 175


Leu Gly Glu Glu Met Arg Glu Asp Gly Leu Ser Pro Asn Glu Ser Lys 
            180                 185                 190


Leu Cys Thr Glu Ser Glu Gly Ile Ser Pro Asn Asn Ser Ala Trp Asn 
        195                 200                 205


Gly Pro Gln Leu Ser Ser Ser Asn Asn Asn Phe Gln Gln Thr Val Ser 
    210                 215                 220


Asp Lys Asn Met Pro Asp Ser Glu Asn Pro Thr Ser Val Phe Ser Arg 
225                 230                 235                 240


Ile Ser Asp His Ser Glu Thr Pro Asn Met Glu Leu Ser Cys Arg Asn 
                245                 250                 255


Gly Gly Ser His Lys Ser Ser Cys Glu Met Arg Ser Leu Val Val Ser 
            260                 265                 270


Thr Ser Ser Asn Lys Gln Asp Val Leu Asn Lys Asp Ser Gly Lys Met 
        275                 280                 285


Lys Gly His Glu Arg Arg Leu Gly Lys Val Ile Pro Val Leu Gln Thr 
    290                 295                 300


Lys Thr Arg Thr Asn Val Pro Thr Phe Ser Gln Ser Asn Leu Glu Gln 
305                 310                 315                 320


Gln Lys Gln Leu Tyr Leu Arg Ser Val Ile Ala His Ile Glu Asp Pro 
                325                 330                 335


Glu Asp Thr Asn Gln Gly Ile Ser Gly Glu Leu Cys Ala Leu Met Asp 
            340                 345                 350


Gln Val His His Met Gln His Ser Lys Trp Gln His Pro Ser Asp Leu 
        355                 360                 365


Thr Thr Arg Asn Tyr Ala Arg Arg Gln Lys His Leu Gln Arg Tyr Ser 
    370                 375                 380


Leu Thr Gln Trp Val Asp Arg Asn Met Arg Ser His His Arg Phe Gln 
385                 390                 395                 400


Arg Leu Pro Asp Phe Ser Tyr Ser 
                405


<210>  1784
<211>  4358
<212>  DNA
<213>  Homo sapiens

<400>  1784
acaaccctcc tagaggcggg acggtttcct gccaatcact gctggtttgc cctccccctg     60

gtgttggccc ggctgactcg gggtagggga ggtcggggag ggggcgataa aatggcgcag    120

ggggcggagt gaggcgcagt cgttcgccca ggctttggcc cggcttccgg aggaaggtgg    180

gagtcaatca ttttgacaag tctcctgaaa ggaacagcta gcaggaactg aaaccttttt    240

ccatttggtc tcgtggcaaa ggcagagatt gctccagcag ctccacacaa aatgatgtgc    300

tcacgggtgc cctctgaaca gtcttctggt acctctctct tgcctaaaga cggtgcccca    360

ttttcttggg attccttgga tgaggatgga ttggatgact ccttgctgga gctgtcagag    420

ggagaagaag atgatggtga tgtaaattac acagaggaag agattgatgc actgttgaag    480

gaagatgacc catcatatga gcagtcttct ggggaagatg atggtgggca tgttgagaag    540

ggagaaagag ggagtcaaat tctacttgat actccccgag agaaaaattc atcgtacagc    600

ctgggaccag tagctgagac tcctgacctc ttcaaactac ctcagctaag tacatcaagt    660

ggtcatggac cagctcatac taaaccatta aacagacgct ctgtactaga aaagaatctt    720

ataaaagtaa ctgttgcacc atttaatcca acagtttgtg atgctctgct tgataaggac    780

gagactgatt cgtccaaaga tactgaaaaa ctctcttccc ttggagaaga gatgagagaa    840

gatggtctta gcccaaatga aagcaaactt tgtactgaat ctgaagggat cagccccaat    900

aactctgcct ggaatgggcc ccagctctct tcttcaaaca ataactttca acagactgtc    960

tctgataaaa atatgcctga cagtgagaac cctacgtctg tattctctcg gatctcagac   1020

cattcagaga ctcctaatat ggagttatcc tgcagaaatg gtggttcaca caagtcaagt   1080

tgtgaaatga gatctctggt tgtttccacc tcatcaaaca aacaggatgt tcttaacaag   1140

gattctggga agatgaaagg ccatgagaga agactaggca aagtcattcc tgttctacaa   1200

actaagacca ggactaatgt tccgacgttt tcacagtcaa atctagaaca gcagaagcag   1260

ctttatctca ggagtgtcat tgctcatata gaagacccag aggacactaa ccaaggtatc   1320

tcgggggagc tttgtgcctt gatggatcaa gttcatcata tgcagcactc aaaatggcag   1380

catccttcgg acctcaccac gcgaaactac gcccgccgac agaaacatct gcaaagatac   1440

agtctgactc agtgggttga caggaacatg cgaagccacc atcggttcca gcgtctccca   1500

gacttctcgt acagttaatt tgtgtcatcc catcagcaat gaaggtccct atccagggtc   1560

ctgcttggag cagcatttca tgttcttttg ctgttttgtg ctttgccgat tttggatttt   1620

atttttcaca aaatttttat ttaaaaaact cgtcaccttt tggaaatgcc cattgccgac   1680

ttgaattttt ttgtatgaag tccctcctga ttttgtgtgt gtgtgtctgt gtttaagcaa   1740

gcgttcggtt ggtatagttt ttttttgttt ttttaattta aattgaaggt agctgcctcc   1800

tgaaagccag cattaagcca gaacacccag gttcaagcaa aagacccacc tctctgcaga   1860

ggcaaagtct actttctggt acctcaaaga aatcattgtt caatcttcca taaggaagag   1920

attctttacc aggctgtgag ccagtgttag ataacttgtg aatggatata agttactttt   1980

aacaacccct cttacttttt tatttgaatc ctctgaatac ctgtcagtat tttaaagttg   2040

gcaatccagg acattataag taggatggag caggagaaga atcctattga aaggacaaat   2100

taaaatagta aatcctctcc tctcccttct gtaggtacta gctgccttga tttttttttg   2160

tgggtggggg ggattttttc attccttatt gaacttattt tgcacaatag tgtttacaaa   2220

tcttatacat cttactttga cagaagactt ataatacctt gtggtcttga gactggttgt   2280

ctcctttgcc tttcttcaag gattttcctt tttcttttta ccccccagtg accactctgc   2340

tctttaggat tctagtggca gtattcttgt aacctgttag acgtggatat acctcttcag   2400

gatggcctcc ttgctgtctt tattgaagag ctgcccaccc agagtcttga ctctagggca   2460

ggctagtgct attgtggtgt cagttgatat ttagtttcat ttgctgaacc ccaaatttga   2520

gtgttagtta gggagcctcc attctgtggg agagtgtgga aaggcactct tttttctcca   2580

tattagttaa caagaggtgt ctttaggccc tggatgttac catctcattt ggtcaagccc   2640

ctgataccta gtttcacatg gatgctaacg tggatgtaat atagttgtga cagcctatgc   2700

acaaaagcat tacctgatct taaggtttgg tattctaacc aaagttgaca gactgtgcgt   2760

ctgtcttaat ggatgtctta ggagttggtt attctctctt ttttttttga gacggagttt   2820

cgctgttgtt gcccaggctg gagtgcaatg gcgtatctcc actcaccaca acctccgcct   2880

cctgggttca agggattctc ctgtcttagc ctcctgagta gctgtgatta caggcatgcg   2940

ccaccatgcc tggctaattt catatttttt agtagagaca ggatttctcc atgttggtca   3000

ggctggtctt gaactcctga cctcaggtga tctgcccacc tcggcctcct aaagtgctgg   3060

gattacaggc atgagccact gcacctggcc ggttattctc tctttacaga tagctataga   3120

catcatttta ggaagtgttg cagtctggca tttgtgctat tgttcattct ctgtgaaggc   3180

tgttcatagt tgctatagcc tgtgtttagt tttgtgattt catcaatccc atctttctgt   3240

gtgagtaatg cattctaaac atcctacccc actttagaaa cggacgtggg gaacgcttgg   3300

tcatttaagc caacaataaa tttaggtgaa tgtccctaag tgtttactgt ttttatccag   3360

tcaaggattt gcttttcctt gaacatttgt tttaaattct ggggccaaaa tgcaaaggag   3420

aagttctatt caaaggcagt agttgaaatc tattatttta gttagcctac ttggcattta   3480

ctacatcggt cacttctcca ggctgcccta aattaggttg atggagtgag acatgccaaa   3540

catccacctt tgggaccata gcatagttaa aattaaatgt agttggaata gctagcattg   3600

cagctacagt agggaactgt agtctagttc cctacagaaa acccaaggag tgaagggaca   3660

ggattttgcc taggcaaaaa tctaagactc gtgccctcct ggtacatggg gttttaagac   3720

tgaatgtgta ataggagcac tgcctttgcc aaatcaaatg agtgacaggt taactagaaa   3780

atgtgacaat cacatttcct cttagctcaa ataattctgt ttttccaaag ctttagcagc   3840

ttaattaaat ctgttggact gggggaggag agagctgttc tctagtggtt aacatggtat   3900

tctttaagaa gaaaaaacaa agccaaagaa aactcattat ctggcatgtt cgccttaaag   3960

atggtactgg gtagaatctg gagttttcat ctcttttcaa agctgcatat ctcttatatt   4020

tggtattggc ctctaagtct aatattgcag ttggaattct tgctgtatta ttttttaagc   4080

aagtgttagg tgcatttaac tgctttcttc atccatgacg acattcccac catgggggtc   4140

ttgacaaagc agagtaaaaa tatgctgttt acattgttta cttacaagta aggagcctga   4200

aataacctgt agtttcgaat gcaggccctg atttactggc gttgtcagtt tcaattatga   4260

aactgaagtt tggtgcctcc tctttatcat gttttttccc ttgtagcagt tgtgtttaat   4320

gtcattaaaa agaaataaaa gttctttgtc agtgacat                           4358


<210>  1785
<211>  408
<212>  PRT
<213>  Homo sapiens

<400>  1785

Met Met Cys Ser Arg Val Pro Ser Glu Gln Ser Ser Gly Thr Ser Leu 
1               5                   10                  15


Leu Pro Lys Asp Gly Ala Pro Phe Ser Trp Asp Ser Leu Asp Glu Asp 
            20                  25                  30


Gly Leu Asp Asp Ser Leu Leu Glu Leu Ser Glu Gly Glu Glu Asp Asp 
        35                  40                  45


Gly Asp Val Asn Tyr Thr Glu Glu Glu Ile Asp Ala Leu Leu Lys Glu 
    50                  55                  60


Asp Asp Pro Ser Tyr Glu Gln Ser Ser Gly Glu Asp Asp Gly Gly His 
65                  70                  75                  80


Val Glu Lys Gly Glu Arg Gly Ser Gln Ile Leu Leu Asp Thr Pro Arg 
                85                  90                  95


Glu Lys Asn Ser Ser Tyr Ser Leu Gly Pro Val Ala Glu Thr Pro Asp 
            100                 105                 110


Leu Phe Lys Leu Pro Gln Leu Ser Thr Ser Ser Gly His Gly Pro Ala 
        115                 120                 125


His Thr Lys Pro Leu Asn Arg Arg Ser Val Leu Glu Lys Asn Leu Ile 
    130                 135                 140


Lys Val Thr Val Ala Pro Phe Asn Pro Thr Val Cys Asp Ala Leu Leu 
145                 150                 155                 160


Asp Lys Asp Glu Thr Asp Ser Ser Lys Asp Thr Glu Lys Leu Ser Ser 
                165                 170                 175


Leu Gly Glu Glu Met Arg Glu Asp Gly Leu Ser Pro Asn Glu Ser Lys 
            180                 185                 190


Leu Cys Thr Glu Ser Glu Gly Ile Ser Pro Asn Asn Ser Ala Trp Asn 
        195                 200                 205


Gly Pro Gln Leu Ser Ser Ser Asn Asn Asn Phe Gln Gln Thr Val Ser 
    210                 215                 220


Asp Lys Asn Met Pro Asp Ser Glu Asn Pro Thr Ser Val Phe Ser Arg 
225                 230                 235                 240


Ile Ser Asp His Ser Glu Thr Pro Asn Met Glu Leu Ser Cys Arg Asn 
                245                 250                 255


Gly Gly Ser His Lys Ser Ser Cys Glu Met Arg Ser Leu Val Val Ser 
            260                 265                 270


Thr Ser Ser Asn Lys Gln Asp Val Leu Asn Lys Asp Ser Gly Lys Met 
        275                 280                 285


Lys Gly His Glu Arg Arg Leu Gly Lys Val Ile Pro Val Leu Gln Thr 
    290                 295                 300


Lys Thr Arg Thr Asn Val Pro Thr Phe Ser Gln Ser Asn Leu Glu Gln 
305                 310                 315                 320


Gln Lys Gln Leu Tyr Leu Arg Ser Val Ile Ala His Ile Glu Asp Pro 
                325                 330                 335


Glu Asp Thr Asn Gln Gly Ile Ser Gly Glu Leu Cys Ala Leu Met Asp 
            340                 345                 350


Gln Val His His Met Gln His Ser Lys Trp Gln His Pro Ser Asp Leu 
        355                 360                 365


Thr Thr Arg Asn Tyr Ala Arg Arg Gln Lys His Leu Gln Arg Tyr Ser 
    370                 375                 380


Leu Thr Gln Trp Val Asp Arg Asn Met Arg Ser His His Arg Phe Gln 
385                 390                 395                 400


Arg Leu Pro Asp Phe Ser Tyr Ser 
                405


<210>  1786
<211>  345
<212>  DNA
<213>  Homo sapiens

<400>  1786
gtcgttcgcc caggctttgg cccggcttcc ggagggactc caagctctac cagacctgcc     60

tgaagtgttt taaagcacat tttctttttg aaaagaaacc tgttgctgca gcttagcgca    120

tctgttctct gtgtccatgt gggaggagaa tcctggcacc ctcatctagt gaaatgttac    180

ctaaagcaaa gatttgcagc cctgggttgt tttttccgtc ctgcagtgtt tttagttact    240

tcgaaggaat ttgcaaaact gttacagata atttcagttc tttttgattt tttgtaaatg    300

ttgtgcctat tttttatgga gtgataaagc ctgctgagtg cgttt                    345


<210>  1787
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  1787

Met Leu Pro Lys Ala Lys Ile Cys Ser Pro Gly Leu Phe Phe Pro Ser 
1               5                   10                  15


Cys Ser Val Phe Ser Tyr Phe Glu Gly Ile Cys Lys Thr Val Thr Asp 
            20                  25                  30


Asn Phe Ser Ser Phe 
        35


<210>  1788
<211>  417
<212>  DNA
<213>  Homo sapiens

<400>  1788
ggatgggggc gcctgttgct tctccagggg gttgcgcacg ccgtccgccc cttggaggga     60

ttgggaggcc cacgccctgc tgcgagaagg gcgcgttcta gctcctgagg gactccaagc    120

tctaccagac ctgcctgaag tgttttaaag cacattttct ttttgaaaag aaacctgttg    180

ctgcagctta gcgcatctgt tctctgtgtc catgtgggag gagaatcctg gcaccctcat    240

ctagtgaaat gttacctaaa gcaaagattt gcagccctgg gttgtttttt ccgtcctgca    300

gtgtttttag ttacttcgaa ggaatttgca aaactgttac agataatttc agttcttttt    360

gattttttgt aaatgttgtg cctatttttt atggagtgat aaagcctgct gagtgcg       417


<210>  1789
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  1789

Met Leu Pro Lys Ala Lys Ile Cys Ser Pro Gly Leu Phe Phe Pro Ser 
1               5                   10                  15


Cys Ser Val Phe Ser Tyr Phe Glu Gly Ile Cys Lys Thr Val Thr Asp 
            20                  25                  30


Asn Phe Ser Ser Phe 
        35


<210>  1790
<211>  557
<212>  DNA
<213>  Homo sapiens

<400>  1790
ctcgcgtatt gtttttttaa taaagtaatt gcagggggaa aagatctgaa atttttagat     60

taaaatacac ataagacatt atcagccagt cacattgtat ggaccttact tggatactga    120

ttatttttta gccttaaaaa aaaatatgac ataagataat tggaaatctg aactgtatat    180

tttatgataa ggaattcttg ttatttacag atgaaatgat acaatgcctg ggatttgctt    240

caaaacaatc tggtaaaggt gggaagtgga tggggcaaga ttagctatga gttgatagtc    300

attggggttg agtgatgggt atgtggtggt tcattatact attatgttac ttatgtatat    360

gttttacttt ctttataata agtacttttg aaaatgagga acaaaactag tttgcttagt    420

tgcataattt ttttttcttt gaagatttct ttggtgtgct tgactcagaa aatccaactt    480

tctggtatta caaaaaaaat caagattaaa attaatacat cgagcacctt aaagcataat    540

acagttgact ttgtaat                                                   557


<210>  1791
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  1791

Met Arg Asn Lys Thr Ser Leu Leu Ser Cys Ile Ile Phe Phe Ser Leu 
1               5                   10                  15


Lys Ile Ser Leu Val Cys Leu Thr Gln Lys Ile Gln Leu Ser Gly Ile 
            20                  25                  30


Thr Lys Lys Ile Lys Ile Lys Ile Asn Thr Ser Ser Thr Leu Lys His 
        35                  40                  45


Asn Thr Val Asp Phe 
    50


<210>  1792
<211>  13723
<212>  DNA
<213>  Homo sapiens

<400>  1792
agcgggattg gagcgagtca tttccgagag cgcagcgcgc ctctccccgg ccgggcggac     60

acttggttca ttccagccgc agaagctcag ggctcccgcg taccgggatt ttttccgagc    120

agaaaaaagc tccagagctc tcctgacctc ctttctcctc ggcggcgagc ggagcctctc    180

cctcggcgct gccggccgcg ccatgccgcg ctcgcgggga cgggagctgg ggcgctgcgg    240

ctgccccgcg gggagggctc gcggcgaaac cgggatttcg gcgcttgtgc cgggcgccgg    300

gagccgctgg ggccgcccgc cgccgccaac gccgccgcct ctgctgctgt tgctgggctg    360

tgggttgctc agcgtctcgg ccgccgcggg ccagaactgc acgttccaac tgcacggtcc    420

caatgggaca gttgagagcc cagggttccc atatggctac cccaattacg ccaactgcac    480

gtggaccatc accgcggaag agcagcacag aatccagctt gtgttccagt cctttgccct    540

ggaagaggac tttgatgtcc tgtcggtgtt tgatggtcca ccccagccag agaatctgcg    600

tacgaggctc acaggctttc agctgccagc caccattgtt agtgcagcca ccaccctctc    660

tctgcgcctc atcagcgact atgcagtcag tgcccaaggc ttccacgcca cctatgaagt    720

tctccccagc cacacatgtg ggaacccagg gaggctgccc aatggcatcc agcagggttc    780

aaccttcaac ctcggtgaca aggtccgcta cagctgcaac cttggcttct tcctggaggg    840

ccacgccgtg ctcacctgcc acgctggctc tgagaacagc gccacgtggg acttccccct    900

gccttcctgc agagctgatg atgcctgtgg tgggaccctg cggggccaga gtggcatcat    960

ctccagcccc cacttcccct cggagtacca taacaatgcc gactgcacat ggaccatcct   1020

ggctgagctg ggggacacca tcgccctggt gtttattgac ttccagctgg aggatggtta   1080

cgactttctg gaagtcactg ggacagaagg ctcctccctc tggttcaccg gagccagcct   1140

cccagccccc gttatcagca gcaagaactg gctgcgactg cacttcacat cggatggcaa   1200

ccaccggcag cgcggattca gtgcccaata ccaagtcaag aagcaaattg agttgaagtc   1260

tcgaggtgtg aagctgatgc ccagcaaaga caacagccag aagacgtctg tgttaactca   1320

ggttggtgtg tcccaaggac ataatatgtg tccagaccct ggcatacccg aaaggggcaa   1380

aagactaggc tcggatttca ggttaggatc cagcgtccag ttcacctgca acgagggcta   1440

tgacctgcaa gggtccaagc ggatcacctg tatgaaagtg agcgacatgt ttgcggcctg   1500

gagcgaccac aggccagtct gccgagcccg catgtgtgat gcccaccttc gaggcccctc   1560

gggcatcatc acctccccca atttccccat tcagtatgac aacaatgcac actgtgtgtg   1620

gatcatcaca gcactcaacc cctccaaggt gatcaagctc gcctttgagg agtttgattt   1680

ggagaggggc tatgacaccc tgacggtcgg tgatggtggt caggatgggg accagaagac   1740

agttctctac atcctgacag gtacatcggt cccggatctc attgtcagca ccaatcatca   1800

aatgtggctc ctcttccaga ctgatggcag tggcagttcc ctgggattca aggcttctta   1860

tgaagagatc gagcagggca gttgcggtga ccctggcata cctgcatatg gccggaggga   1920

aggctcccgg tttcaccacg gtgacacact caagtttgag tgccagcccg cctttgagct   1980

ggtgggacag aaggcaatca catgccaaaa gaataaccaa tggtcggcta agaagccagg   2040

ctgcgtgttc tcctgcttct tcaacttcac cagcccgtct ggggttgtcc tgtctcccaa   2100

ctacccagag gactatggca accacctcca ctgtgtctgg ctcatcctgg ccaggcctga   2160

gagccgcatc cacctggcct tcaacgacat tgacgtggag cctcagtttg atttcctggt   2220

catcaaggat ggggccaccg ccgaggcgcc cgtcctgggc accttctcag gaaaccagct   2280

tccctcctcc atcacaagca gtggccacgt ggcccgtctc gagttccaga ctgaccactc   2340

cacagggaag aggggcttca acatcacttt taccaccttc cgacacaacg agtgcccgga   2400

tcctggcgtt ccagtaaatg gcaaacggtt tggggacagc ctccagctgg gcagctccat   2460

ctccttcctc tgtgatgaag gcttccttgg gactcagggc tcagagacca tcacctgcgt   2520

cctgaaggag ggcagcgtgg tctggaacag cgctgtgctg cggtgtgaag ctccctgtgg   2580

tggtcacctg acttcgccca gcggcaccat cctctctccg ggctggcctg gcttctacaa   2640

ggatgccttg agctgtgcct gggtgattga ggcccagcca ggctacccca tcaaaatcac   2700

cttcgacaga ttcaaaaccg aggtcaacta tgacaccctg gaagtacgcg atgggcggac   2760

ttactcagcg cccttgatcg gggtttacca cgggacccag gttccccagt tcctcatcag   2820

caccagcaac tacctctacc tcctcttctc taccgacaag agtcactcgg acatcggctt   2880

ccagctccgc tatgagacta taacactgca gtcagaccac tgtctggatc caggaatccc   2940

agtaaatgga cagcgtcatg ggaatgactt ctacgtgggc gcgctggtga ccttcagctg   3000

tgactcgggc tacacattaa gtgacgggga gcctctggag tgtgagccca acttccagtg   3060

gagccgggcc ctgcccagtt gtgaagctct ctgtggtggc ttcattcaag gctccagtgg   3120

gaccatcttg tcgccagggt tccctgactt ctaccccaac aacttgaact gcacctggat   3180

tatcgaaaca tctcatggca agggtgtgtt cttcactttc cacaccttcc acctggaaag   3240

tggccatgac tacctcctca tcactgagaa cggcagcttc acccagcccc tgaggcagct   3300

aactggatct cggctgccag ctcccatcag cgctgggctc tatggcaact tcactgccca   3360

ggtccgcttc atctctgatt tctccatgtc atatgaagga ttcaacatca ccttctcaga   3420

gtacgacttg gagccctgtg aggagcccga ggtcccagcc tacagcatcc ggaagggctt   3480

gcagtttggc gtgggcgaca ccttgacctt ctcctgcttc cccgggtacc gtctggaggg   3540

caccgcccgc atcacgtgcc tggggggcag acggcgcctg tggagctcgc ctctgccaag   3600

gtgtgttgct gagtgtggga attcagtcac aggcactcag ggtactttgc tgtcccccaa   3660

ctttcctgtg aactacaata acaatcatga atgcatctac tccatccaga cccagccagg   3720

gaagggaatt cagctgaaag ccagggcatt cgaactctcc gaaggagatg tcctcaaggt   3780

ttatgatggc aacaacaact ccgcccgttt gctgggagtt tttagccatt ctgagatgat   3840

gggggtgact ttgaacagca catccagcag tctgtggctt gatttcatca ctgatgctga   3900

aaacaccagc aagggctttg aactgcactt ttccagcttt gaactcatca aatgtgagga   3960

cccaggaacc cccaagtttg gctacaaggt tcatgatgaa ggtcattttg cagggagctc   4020

cgtgtccttc agctgtgacc ctggatacag cctgcggggt agtgaggagc tgctgtgtct   4080

gagtggagag cgccggacct gggaccggcc tctgcccacc tgtgtcgccg agtgtggagg   4140

gacagtgaga ggagaggtgt cggggcaggt gctgtcaccc gggtatccag ctccctatga   4200

acacaatctc aactgcatct ggaccatcga agcagaggcc ggctgcacca ttgggctaca   4260

cttcctggtg tttgacacag aggaggttca cgacgtgctg cgcatctggg atgggcctgt   4320

ggagagcggg gttctgctga aggagctgag tggcccggcc ctgcccaagg acctgcatag   4380

caccttcaac tcggtcgtcc tgcagttcag cactgacttc ttcaccagca agcagggctt   4440

tgccattcaa ttttcagtgt ccacagcaac gtcctgcaat gaccctggga tcccgcagaa   4500

tgggagtcgg agtggtgaca gttgggaagc cggcgactcc acagtgttcc agtgtgaccc   4560

tggctacgcg ctgcagggaa gtgcagagat cagctgtgtg aagatcgaga acaggttctt   4620

ctggcagccc agcccgccaa catgcatcgc tccctgcggg ggagacctga caggaccatc   4680

tggagtcatc ctctcaccaa attacccaga accctacccg ccaggcaagg agtgtgactg   4740

gaaagtgacc gtctcaccag actacgtcat cgccctggta tttaacatct ttaacctgga   4800

gcctggctat gacttcctcc atatctacga cggacgggac tctctcagcc ctctcatagg   4860

aagcttctat ggctcccagc tcccaggccg cattgaaagc agcagcaaca gcctcttcct   4920

cgccttccgc agcgatgcat ctgtgagcaa tgctggcttc gtcattgact atacagaaaa   4980

cccgcgggag tcatgttttg atcctggttc catcaagaac ggcacacggg tggggtccga   5040

cctgaagctg ggctcctccg tcacctacta ctgccacggg ggctacgaag ttgagggcac   5100

ctcgaccctg agctgcatcc tggggcctga tgggaagccc gtgtggaaca atccccggcc   5160

agtctgcaca gccccctgtg ggggacagta tgtgggttcg gacggagtgg tcttgtcccc   5220

caactacccc cagaactaca ccagtggaca gatctgcttg tattttgtta ctgtgcccaa   5280

ggactatgtg gtgtttggcc agttcgcctt ctttcacacg gccctcaacg acgtggtgga   5340

ggttcacgac ggccacagcc agcactcgcg gctcctcagc tccctctcgg gctcccatac   5400

aggagaatca ctgcccttgg ccacctccaa tcaagttctc attaagttca gcgccaaagg   5460

cctcgcacca gccagaggct tccactttgt ctaccaagcg gttcctcgaa ccagcgccac   5520

gcagtgcagc tctgtgccgg aaccccgcta tggcaagagg ctgggcagtg acttctcggt   5580

gggggccatc gtccgcttcg aatgcaactc cggctatgcc ctgcaggggt cgccagagat   5640

cgagtgcctc cctgtgcctg gggccttggc ccaatggaat gtctcagcgc ccacgtgtgt   5700

ggtgccgtgt ggaggcaacc tcacagagcg caggggcacc atcctgtccc ctggcttccc   5760

agagccgtac ctcaacagcc tcaactgtgt gtggaagatc gtggtccccg aaggcgctgg   5820

catccagatc caagttgtca gttttgtgac agagcagaac tgggactcgc tggaagtatt   5880

tgatggtgca gataacactg taaccatgct ggggagtttc tcaggaacaa ccgtgcctgc   5940

ccttctgaac agcacctcca accagctcta ccttcatttc tactcagata tcagcgtatc   6000

tgcagctggc ttccacttgg agtacaaaac ggtgggcctg agcagttgtc cggaacctgc   6060

tgtgcccagt aacggggtga agactggcga gcgctacttg gtgaatgatg tggtgtcttt   6120

ccagtgtgag ccgggatatg ccctccaggg ccacgcccac atctcctgca tgcccggaac   6180

agtgcggcga tggaactacc ctcctccact ctgtattgca cagtgtgggg gaacagtgga   6240

ggagatggag ggggtgatcc tgagccccgg cttcccaggc aactacccca gtaacatgga   6300

ctgctcctgg aaaatagcac tgcccgtggg ctttggagct cacatccagt tcctgaactt   6360

ctccaccgag cccaaccacg actacataga aatccggaat ggcccctatg agaccagccg   6420

catgatggga agattcagtg gaagcgagct tccaagctcc ctcctctcca cgtcccacga   6480

gaccaccgtg tatttccaca gcgaccactc ccagaatcgg ccaggattca agctggagta   6540

tcaggcctat gaacttcaag agtgcccaga cccagagccc tttgccaatg gcattgtgag   6600

gggagctggc tacaacgtgg gacaatcagt gaccttcgag tgcctcccgg ggtatcaatt   6660

gactggccac cctgtcctca cgtgtcaaca tggcaccaac cggaactggg accaccccct   6720

gcccaagtgt gaagtccctt gtggcgggaa catcacttct tccaacggca ctgtgtactc   6780

cccggggttc cctagcccgt actccagctc ccaggactgt gtctggctga tcaccgtgcc   6840

cattggccat ggcgtccgcc tcaacctcag cctgctgcag acagagccct ctggagattt   6900

catcaccatc tgggatgggc cacagcaaac agcaccacgg ctcggcgtct tcacccggag   6960

catggccaag aaaacagtgc agagttcatc caaccaggtc ctgctcaagt tccaccgtga   7020

tgcagccaca ggggggatct tcgccatagc tttctccgct tatccactca ccaaatgccc   7080

tcctcccacc atcctcccca acgccgaagt cgtcacagag aatgaagaat tcaatatagg   7140

tgacatcgta cgctacagat gcctccctgg ctttacctta gtggggaatg aaattctgac   7200

ctgcaaactt ggaacctacc tgcagtttga aggaccaccc ccgatatgtg aagtgcactg   7260

tccaacaaat gagcttctga cagactccac aggcgtgatc ctgagccaga gctaccctgg   7320

aagctatccc cagttccaga cctgctcttg gctggtgaga gtggagcccg actataacat   7380

ctccctcaca gtggagtact tcctcagcga gaagcaatat gatgagtttg agatttttga   7440

tggtccatca ggacagagtc ctctgctgaa agccctcagt gggaattact cagctcccct   7500

gattgtcacc agctcaagca actctgtgta cctgcgttgg tcatctgatc acgcctacaa   7560

tcggaagggc ttcaagatcc gctattcagc cccttactgc agcctgccca gggctccact   7620

ccatggcttc atcctaggcc agaccagcac ccagcccggg ggctccatcc actttggctg   7680

caacgccggc taccgcctgg tgggacacag catggccatc tgtacccggc acccccaggg   7740

ctaccacctg tggagcgaag ccatccctct ctgtcaagct ctttcctgtg ggcttcctga   7800

ggcccccaag aatggaatgg tgtttggcaa ggagtacaca gtgggaacca aggccatgta   7860

cagctgcagt gaaggctacc acctccaggc aggcgctgag gccactgcag agtgtctgga   7920

cacaggccta tggagcaacc gcaatgtccc accacagtgt gtccctgtga cttgtcctga   7980

tgtcagtagc atcagcgtgg agcatggccg atggaggctt atctttgaga cacagtatca   8040

gttccaggcc cagctgatgc tcatctgtga ccctggctac tactatactg gccaaagggt   8100

catccgctgt caggccaatg gcaaatggag cctcggggac tctacgccca cctgccgaat   8160

catctcctgt ggagagctcc cgattccccc caatggccac cgcatcggaa cactgtctgt   8220

ctacggggca acagccatct tctcctgcaa ttccggatac acactggtgg gctccagggt   8280

gcgtgagtgc atggccaatg ggctctggag tggctctgaa gtccgctgcc ttgccactca   8340

gaccaagctc cactccattt tctataagct cctcttcgat gtactctctt ccccatccct   8400

caccaaagct ggacactgtg ggactcctga gcccattgtc aacggacaca tcaatgggga   8460

gaactacagc taccggggca gtgtggtgta ccaatgcaat gctggcttcc gcctgatcgg   8520

catgtctgtg cgcatctgcc agcaggatca tcactggtcg ggcaagaccc ctttctgtgt   8580

gccaattacc tgtggacacc caggcaaccc tgtcaacggc ctcactcagg gtaaccagtt   8640

taacctcaac gatgtggtca agtttgtttg caaccctggg tatatggctg agggggctgc   8700

taggtcccaa tgcctggcca gcgggcaatg gagtgacatg ctgcccacct gcagaatcat   8760

caactgtaca gatcctggac accaagaaaa tagtgttcgt caggtccacg ccagcggccc   8820

gcacaggttc agcttcggca ccactgtgtc ttaccggtgc aaccacggct tctacctcct   8880

gggcacccca gtgctcagct gccagggaga tggcacatgg gaccgtcccc gcccccagtg   8940

tctcttggtg tcctgtggcc atccgggctc cccgcctcac tcccagatgt ctggagacag   9000

ttatactgtg ggagcagtgg tgcggtacag ctgcatcggc aagcgtactc tggtgggaaa   9060

cagcacccgc atgtgtgggc tggatggaca ctggactggc tccctccctc actgctcagg   9120

aaccagcgtg ggagtttgcg gtgaccctgg gatcccggct catggcatcc gtttggggga   9180

cagctttgat ccaggcactg tgatgcgctt cagctgtgaa gctggccacg tgctccgggg   9240

atcgtcagag cgcacctgtc aagccaatgg ctcgtggagc ggctcgcagc ctgagtgtgg   9300

agtgatctct tgtgggaacc ctgggactcc aagtaatgcc cgagttgtgt tcagtgatgg   9360

cctggttttc tccagctcta tcgtctatga gtgccgggaa ggatactacg ccacaggcct   9420

gctcagccgt cactgctcgg tcaatggtac ctggacaggc agtgaccctg agtgcctcgt   9480

cataaactgt ggtgaccctg ggattccagc caatggcctt cggctgggca atgacttcag   9540

gtacaacaaa actgtgacat atcagtgtgt ccctggctat atgatggagt cacatagagt   9600

atctgtgctg agctgcacca aggaccggac atggaatgga accaagcccg tctgcaaagc   9660

tctcatgtgc aagccacctc cgctcatccc caatgggaag gtggtggggt ctgacttcat   9720

gtggggctca agtgtgactt atgcctgcct ggaggggtac cagctctccc tgcccgcggt   9780

gttcacctgt gagggaaatg ggtcctggac cggagagctg cctcagtgtt tccctgtgtt   9840

ctgcggggat cctggtgtcc cgtcccgtgg gaggagagag gaccgaggct tctcctacag   9900

gtcatctgtc tccttctcct gccatccccc tctggtgctg gtgggctctc cacgcaggtt   9960

ttgccagtca gatgggacat ggagtggcac ccagcccagc tgcatagatc cgaccctgac  10020

cacgtgtgcg gaccctggtg tgccacagtt tgggatacag aacaattctc agggctacca  10080

ggttggaagc acagtcctct tccgttgtca aaaaggctac ctgcttcagg gctccaccac  10140

caggacctgc ctcccaaacc tgacctggag tggaacccca cctgactgtg tcccccacca  10200

ctgcaggcag ccagagacgc caacgcatgc caacgtcggg gccctggatt tgccctccat  10260

gggctacacg ctcatctact cctgccagga gggcttctcc ctcaagggtg gctccgagca  10320

ccgcacctgc aaggcggatg gcagctggac aggcaagccg cccatctgcc tggaggtccg  10380

gcccagtggg agacccatca acactgcccg ggagccaccg ctcacccaag ccttgattcc  10440

tggggatgtt tttgccaaga attccctgtg gaaaggggcc tatgaatacc aggggaagaa  10500

gcagccagcc atgctcagag tgactggctt ccaagttgcc aacagcaagg tcaatgccac  10560

catgatcgac cacagtggcg tggagctgca cttggctgga acttacaaga aagaagattt  10620

tcatctccta ctccaggtgt accagattac agggcctgtg gagatcttta tgaataagtt  10680

caaagatgat cactgggctt tagatggcca tgtctcgtca gagtcctccg gagccacctt  10740

catctaccaa ggctctgtca agggccaagg ctttgggcag ttcggctttc aaagactgga  10800

cctcaggctg ctggagtcag accccgagtc cattggccgc cactttgctt ccaacagcag  10860

ctcagtggca gccgcgatcc tggtgccttt catcgccctc attattgcgg gcttcgtgct  10920

ctatctctac aagcacagga gaagacccaa agttcctttc aatggctatg ctggccacga  10980

gaacaccaat gttcgggcca catttgagaa cccaatgtac gaccgcaaca tccagcccac  11040

agacatcatg gccagcgagg cggagttcac agtcagcaca gtgtgcacag cagtatagcc  11100

acccggcctg gccgccacca ccgccaccga gagccccgcc tccagcagcc gttccccagg  11160

gggcaggaag taggctcccc tgagcacagt gcccagtgcc catcttcgtt cgtctccttg  11220

cctgtgtctg ctactgctgg gactcaggcc ctcgccctgc cgccatctat gccagttacc  11280

ctggagagga ctcctgccgt gtcctgaaaa ggcagaaaag gaagaggggc tgcagacaga  11340

ggaagaaagt ttatggattt aaaatagcaa agcaacttgt ggatctgtgt gtgtgtgtgt  11400

gtgtatgggc ctgatcacac acaaacacac acacctctcc ttcattcacg tcctatggaa  11460

gagaccataa aggcttcaaa actagaagtg cgcatgaagg atgcttcatg ccctgttccc  11520

cacacagaga agagatgaag agggggaggt acggtcagct ttcaaaacaa tatgcccccc  11580

gcccatccca tgtgtgagga catggtgact cggtgactgt aacagtagga cacatcccat  11640

catgcggtca gagtgcagaa acccggtcag cgtgcagaaa ccagctgtct gctgatgaac  11700

ggcccatctg cacagcggca gcaaggatta ccccaagggc aggaaaaaag tctttggaaa  11760

tagattgaaa atcagtttct ttattttttt caaacactgt tttattgagt tctaaaccca  11820

gtggattaaa aagtcatttg ggtcctggga agcactggga aagaagggag agccggggag  11880

gatagggcag gagtctggcc aggagcccaa ggtcaagtct ggctgtcaac tgacaaagag  11940

aagagaagac aagtctgtgg cccagacagg atgccaagtc tgggggcagc agcagggtcc  12000

ttgagagaac aggggagcaa gcctgcccca gtacccaaaa aacaatggct atcatgtact  12060

ggggttattc tctgtgcctg acactttacc tgtagtattt ctagtctgca caataacacc  12120

aaaatgtagg atttgttatt cccctttgac agatgagaaa acagaagcct gcaaaggtaa  12180

agacagagtt aggaagtgtg gagtcagaat gcaaacccag atcagtctgc cccaaagtcc  12240

actacaccag ctgccagaaa ccctgttcta gaaggggcag ctaagaaggg aggagccgat  12300

gaatctctac agtagcactg tggccaggtc tggaaagcca ggcaagacac ctgtgtgtcc  12360

tatctgggtt ctgctgtctc cgcgtaggca gcttcggggc aaggattcaa ctccccaggc  12420

ctcccacggt tggtgctggc tccttggctc ccagcagccg ctgaccatag ccagcaaaag  12480

acctggcagg tcctgaatca aaacaacaga gtggctgaaa gtcacacctc tccagctcct  12540

tgcgagtggg tttgattgat tttgacagct atatcatgct tgggtcgttc atgaattcca  12600

tgagaattgt tgggaagttc atgagtttag gaatcaaagt atagcattta gggccacttt  12660

ctctgtcctc gggaaggccc ccacaagctt aagcccctgt atacgtgtga catgctggcc  12720

tcagagattc atgtcacata ttgaaatagc aaatagaaat gtgcaggagc ggagggacag  12780

cgacacctgg ttcttaagca aattctagat tggaacaatt agaagatctg actgatgtta  12840

agagtggcca gaggaaagtg agaggcgtcc atttccagca gacacaatgg aggctgacag  12900

aggcaggagc ctacccctgg ccacaccacc tctgggacac ggcacccccc tgggcctgga  12960

gggagagggc caatccagac acactcacac tctcatctct ttccttggct ggaaacaagt  13020

gcaggaagct cccctcccaa tttcttatgc tcccttcccc cttacactcc tctccttcga  13080

ctgctccctt cccccttctt atgcccctct cagaccaccc agcggatgcc tattcccgcc  13140

ccccacccct cccctgcgtc tccttgtaaa gttccatgag atgctcgagg agcacctgct  13200

ggtggggcac ccagcactct gctgggcatc accctccgca cccctgacat ttctctccac  13260

ctccagaggc ttggaaggga acagggcaga tgaggccctt cacccaccat ctacgccata  13320

tacccatcac catcccatga ggaaaaaaaa aaaagtaaaa caaagacaaa aaaaatcttt  13380

tgtacagaga tatattttta ttatacaaag tttgtacagt accaaaaaag aaaaaaaaaa  13440

aggtgtaaat ttttttttca ttattgtagg taaacggtag tggaagcctt ttttgtaaat  13500

gtaataaaat gtataaatat ggttttcaga aaacatcaag tgctgtaaat atgtaatcta  13560

cacaccttct tggcttgtct gcagtatata catttaattt atctgtctct gtatatgagg  13620

cttccccctg gggtcctgca ttatggtact ttcctgaatt tgaaagcaat tttaaatttt  13680

ttgaattcaa ataaaatata aatttttgca ttggttttct tac                    13723


<210>  1793
<211>  3631
<212>  PRT
<213>  Homo sapiens

<400>  1793

Met Pro Arg Ser Arg Gly Arg Glu Leu Gly Arg Cys Gly Cys Pro Ala 
1               5                   10                  15


Gly Arg Ala Arg Gly Glu Thr Gly Ile Ser Ala Leu Val Pro Gly Ala 
            20                  25                  30


Gly Ser Arg Trp Gly Arg Pro Pro Pro Pro Thr Pro Pro Pro Leu Leu 
        35                  40                  45


Leu Leu Leu Gly Cys Gly Leu Leu Ser Val Ser Ala Ala Ala Gly Gln 
    50                  55                  60


Asn Cys Thr Phe Gln Leu His Gly Pro Asn Gly Thr Val Glu Ser Pro 
65                  70                  75                  80


Gly Phe Pro Tyr Gly Tyr Pro Asn Tyr Ala Asn Cys Thr Trp Thr Ile 
                85                  90                  95


Thr Ala Glu Glu Gln His Arg Ile Gln Leu Val Phe Gln Ser Phe Ala 
            100                 105                 110


Leu Glu Glu Asp Phe Asp Val Leu Ser Val Phe Asp Gly Pro Pro Gln 
        115                 120                 125


Pro Glu Asn Leu Arg Thr Arg Leu Thr Gly Phe Gln Leu Pro Ala Thr 
    130                 135                 140


Ile Val Ser Ala Ala Thr Thr Leu Ser Leu Arg Leu Ile Ser Asp Tyr 
145                 150                 155                 160


Ala Val Ser Ala Gln Gly Phe His Ala Thr Tyr Glu Val Leu Pro Ser 
                165                 170                 175


His Thr Cys Gly Asn Pro Gly Arg Leu Pro Asn Gly Ile Gln Gln Gly 
            180                 185                 190


Ser Thr Phe Asn Leu Gly Asp Lys Val Arg Tyr Ser Cys Asn Leu Gly 
        195                 200                 205


Phe Phe Leu Glu Gly His Ala Val Leu Thr Cys His Ala Gly Ser Glu 
    210                 215                 220


Asn Ser Ala Thr Trp Asp Phe Pro Leu Pro Ser Cys Arg Ala Asp Asp 
225                 230                 235                 240


Ala Cys Gly Gly Thr Leu Arg Gly Gln Ser Gly Ile Ile Ser Ser Pro 
                245                 250                 255


His Phe Pro Ser Glu Tyr His Asn Asn Ala Asp Cys Thr Trp Thr Ile 
            260                 265                 270


Leu Ala Glu Leu Gly Asp Thr Ile Ala Leu Val Phe Ile Asp Phe Gln 
        275                 280                 285


Leu Glu Asp Gly Tyr Asp Phe Leu Glu Val Thr Gly Thr Glu Gly Ser 
    290                 295                 300


Ser Leu Trp Phe Thr Gly Ala Ser Leu Pro Ala Pro Val Ile Ser Ser 
305                 310                 315                 320


Lys Asn Trp Leu Arg Leu His Phe Thr Ser Asp Gly Asn His Arg Gln 
                325                 330                 335


Arg Gly Phe Ser Ala Gln Tyr Gln Val Lys Lys Gln Ile Glu Leu Lys 
            340                 345                 350


Ser Arg Gly Val Lys Leu Met Pro Ser Lys Asp Asn Ser Gln Lys Thr 
        355                 360                 365


Ser Val Leu Thr Gln Val Gly Val Ser Gln Gly His Asn Met Cys Pro 
    370                 375                 380


Asp Pro Gly Ile Pro Glu Arg Gly Lys Arg Leu Gly Ser Asp Phe Arg 
385                 390                 395                 400


Leu Gly Ser Ser Val Gln Phe Thr Cys Asn Glu Gly Tyr Asp Leu Gln 
                405                 410                 415


Gly Ser Lys Arg Ile Thr Cys Met Lys Val Ser Asp Met Phe Ala Ala 
            420                 425                 430


Trp Ser Asp His Arg Pro Val Cys Arg Ala Arg Met Cys Asp Ala His 
        435                 440                 445


Leu Arg Gly Pro Ser Gly Ile Ile Thr Ser Pro Asn Phe Pro Ile Gln 
    450                 455                 460


Tyr Asp Asn Asn Ala His Cys Val Trp Ile Ile Thr Ala Leu Asn Pro 
465                 470                 475                 480


Ser Lys Val Ile Lys Leu Ala Phe Glu Glu Phe Asp Leu Glu Arg Gly 
                485                 490                 495


Tyr Asp Thr Leu Thr Val Gly Asp Gly Gly Gln Asp Gly Asp Gln Lys 
            500                 505                 510


Thr Val Leu Tyr Ile Leu Thr Gly Thr Ser Val Pro Asp Leu Ile Val 
        515                 520                 525


Ser Thr Asn His Gln Met Trp Leu Leu Phe Gln Thr Asp Gly Ser Gly 
    530                 535                 540


Ser Ser Leu Gly Phe Lys Ala Ser Tyr Glu Glu Ile Glu Gln Gly Ser 
545                 550                 555                 560


Cys Gly Asp Pro Gly Ile Pro Ala Tyr Gly Arg Arg Glu Gly Ser Arg 
                565                 570                 575


Phe His His Gly Asp Thr Leu Lys Phe Glu Cys Gln Pro Ala Phe Glu 
            580                 585                 590


Leu Val Gly Gln Lys Ala Ile Thr Cys Gln Lys Asn Asn Gln Trp Ser 
        595                 600                 605


Ala Lys Lys Pro Gly Cys Val Phe Ser Cys Phe Phe Asn Phe Thr Ser 
    610                 615                 620


Pro Ser Gly Val Val Leu Ser Pro Asn Tyr Pro Glu Asp Tyr Gly Asn 
625                 630                 635                 640


His Leu His Cys Val Trp Leu Ile Leu Ala Arg Pro Glu Ser Arg Ile 
                645                 650                 655


His Leu Ala Phe Asn Asp Ile Asp Val Glu Pro Gln Phe Asp Phe Leu 
            660                 665                 670


Val Ile Lys Asp Gly Ala Thr Ala Glu Ala Pro Val Leu Gly Thr Phe 
        675                 680                 685


Ser Gly Asn Gln Leu Pro Ser Ser Ile Thr Ser Ser Gly His Val Ala 
    690                 695                 700


Arg Leu Glu Phe Gln Thr Asp His Ser Thr Gly Lys Arg Gly Phe Asn 
705                 710                 715                 720


Ile Thr Phe Thr Thr Phe Arg His Asn Glu Cys Pro Asp Pro Gly Val 
                725                 730                 735


Pro Val Asn Gly Lys Arg Phe Gly Asp Ser Leu Gln Leu Gly Ser Ser 
            740                 745                 750


Ile Ser Phe Leu Cys Asp Glu Gly Phe Leu Gly Thr Gln Gly Ser Glu 
        755                 760                 765


Thr Ile Thr Cys Val Leu Lys Glu Gly Ser Val Val Trp Asn Ser Ala 
    770                 775                 780


Val Leu Arg Cys Glu Ala Pro Cys Gly Gly His Leu Thr Ser Pro Ser 
785                 790                 795                 800


Gly Thr Ile Leu Ser Pro Gly Trp Pro Gly Phe Tyr Lys Asp Ala Leu 
                805                 810                 815


Ser Cys Ala Trp Val Ile Glu Ala Gln Pro Gly Tyr Pro Ile Lys Ile 
            820                 825                 830


Thr Phe Asp Arg Phe Lys Thr Glu Val Asn Tyr Asp Thr Leu Glu Val 
        835                 840                 845


Arg Asp Gly Arg Thr Tyr Ser Ala Pro Leu Ile Gly Val Tyr His Gly 
    850                 855                 860


Thr Gln Val Pro Gln Phe Leu Ile Ser Thr Ser Asn Tyr Leu Tyr Leu 
865                 870                 875                 880


Leu Phe Ser Thr Asp Lys Ser His Ser Asp Ile Gly Phe Gln Leu Arg 
                885                 890                 895


Tyr Glu Thr Ile Thr Leu Gln Ser Asp His Cys Leu Asp Pro Gly Ile 
            900                 905                 910


Pro Val Asn Gly Gln Arg His Gly Asn Asp Phe Tyr Val Gly Ala Leu 
        915                 920                 925


Val Thr Phe Ser Cys Asp Ser Gly Tyr Thr Leu Ser Asp Gly Glu Pro 
    930                 935                 940


Leu Glu Cys Glu Pro Asn Phe Gln Trp Ser Arg Ala Leu Pro Ser Cys 
945                 950                 955                 960


Glu Ala Leu Cys Gly Gly Phe Ile Gln Gly Ser Ser Gly Thr Ile Leu 
                965                 970                 975


Ser Pro Gly Phe Pro Asp Phe Tyr Pro Asn Asn Leu Asn Cys Thr Trp 
            980                 985                 990


Ile Ile Glu Thr Ser His Gly Lys Gly Val Phe Phe Thr Phe His Thr 
        995                 1000                1005


Phe His Leu Glu Ser Gly His Asp Tyr Leu Leu Ile Thr Glu Asn Gly 
    1010                1015                1020


Ser Phe Thr Gln Pro Leu Arg Gln Leu Thr Gly Ser Arg Leu Pro Ala 
1025                1030                1035                1040


Pro Ile Ser Ala Gly Leu Tyr Gly Asn Phe Thr Ala Gln Val Arg Phe 
                1045                1050                1055


Ile Ser Asp Phe Ser Met Ser Tyr Glu Gly Phe Asn Ile Thr Phe Ser 
            1060                1065                1070


Glu Tyr Asp Leu Glu Pro Cys Glu Glu Pro Glu Val Pro Ala Tyr Ser 
        1075                1080                1085


Ile Arg Lys Gly Leu Gln Phe Gly Val Gly Asp Thr Leu Thr Phe Ser 
    1090                1095                1100


Cys Phe Pro Gly Tyr Arg Leu Glu Gly Thr Ala Arg Ile Thr Cys Leu 
1105                1110                1115                1120


Gly Gly Arg Arg Arg Leu Trp Ser Ser Pro Leu Pro Arg Cys Val Ala 
                1125                1130                1135


Glu Cys Gly Asn Ser Val Thr Gly Thr Gln Gly Thr Leu Leu Ser Pro 
            1140                1145                1150


Asn Phe Pro Val Asn Tyr Asn Asn Asn His Glu Cys Ile Tyr Ser Ile 
        1155                1160                1165


Gln Thr Gln Pro Gly Lys Gly Ile Gln Leu Lys Ala Arg Ala Phe Glu 
    1170                1175                1180


Leu Ser Glu Gly Asp Val Leu Lys Val Tyr Asp Gly Asn Asn Asn Ser 
1185                1190                1195                1200


Ala Arg Leu Leu Gly Val Phe Ser His Ser Glu Met Met Gly Val Thr 
                1205                1210                1215


Leu Asn Ser Thr Ser Ser Ser Leu Trp Leu Asp Phe Ile Thr Asp Ala 
            1220                1225                1230


Glu Asn Thr Ser Lys Gly Phe Glu Leu His Phe Ser Ser Phe Glu Leu 
        1235                1240                1245


Ile Lys Cys Glu Asp Pro Gly Thr Pro Lys Phe Gly Tyr Lys Val His 
    1250                1255                1260


Asp Glu Gly His Phe Ala Gly Ser Ser Val Ser Phe Ser Cys Asp Pro 
1265                1270                1275                1280


Gly Tyr Ser Leu Arg Gly Ser Glu Glu Leu Leu Cys Leu Ser Gly Glu 
                1285                1290                1295


Arg Arg Thr Trp Asp Arg Pro Leu Pro Thr Cys Val Ala Glu Cys Gly 
            1300                1305                1310


Gly Thr Val Arg Gly Glu Val Ser Gly Gln Val Leu Ser Pro Gly Tyr 
        1315                1320                1325


Pro Ala Pro Tyr Glu His Asn Leu Asn Cys Ile Trp Thr Ile Glu Ala 
    1330                1335                1340


Glu Ala Gly Cys Thr Ile Gly Leu His Phe Leu Val Phe Asp Thr Glu 
1345                1350                1355                1360


Glu Val His Asp Val Leu Arg Ile Trp Asp Gly Pro Val Glu Ser Gly 
                1365                1370                1375


Val Leu Leu Lys Glu Leu Ser Gly Pro Ala Leu Pro Lys Asp Leu His 
            1380                1385                1390


Ser Thr Phe Asn Ser Val Val Leu Gln Phe Ser Thr Asp Phe Phe Thr 
        1395                1400                1405


Ser Lys Gln Gly Phe Ala Ile Gln Phe Ser Val Ser Thr Ala Thr Ser 
    1410                1415                1420


Cys Asn Asp Pro Gly Ile Pro Gln Asn Gly Ser Arg Ser Gly Asp Ser 
1425                1430                1435                1440


Trp Glu Ala Gly Asp Ser Thr Val Phe Gln Cys Asp Pro Gly Tyr Ala 
                1445                1450                1455


Leu Gln Gly Ser Ala Glu Ile Ser Cys Val Lys Ile Glu Asn Arg Phe 
            1460                1465                1470


Phe Trp Gln Pro Ser Pro Pro Thr Cys Ile Ala Pro Cys Gly Gly Asp 
        1475                1480                1485


Leu Thr Gly Pro Ser Gly Val Ile Leu Ser Pro Asn Tyr Pro Glu Pro 
    1490                1495                1500


Tyr Pro Pro Gly Lys Glu Cys Asp Trp Lys Val Thr Val Ser Pro Asp 
1505                1510                1515                1520


Tyr Val Ile Ala Leu Val Phe Asn Ile Phe Asn Leu Glu Pro Gly Tyr 
                1525                1530                1535


Asp Phe Leu His Ile Tyr Asp Gly Arg Asp Ser Leu Ser Pro Leu Ile 
            1540                1545                1550


Gly Ser Phe Tyr Gly Ser Gln Leu Pro Gly Arg Ile Glu Ser Ser Ser 
        1555                1560                1565


Asn Ser Leu Phe Leu Ala Phe Arg Ser Asp Ala Ser Val Ser Asn Ala 
    1570                1575                1580


Gly Phe Val Ile Asp Tyr Thr Glu Asn Pro Arg Glu Ser Cys Phe Asp 
1585                1590                1595                1600


Pro Gly Ser Ile Lys Asn Gly Thr Arg Val Gly Ser Asp Leu Lys Leu 
                1605                1610                1615


Gly Ser Ser Val Thr Tyr Tyr Cys His Gly Gly Tyr Glu Val Glu Gly 
            1620                1625                1630


Thr Ser Thr Leu Ser Cys Ile Leu Gly Pro Asp Gly Lys Pro Val Trp 
        1635                1640                1645


Asn Asn Pro Arg Pro Val Cys Thr Ala Pro Cys Gly Gly Gln Tyr Val 
    1650                1655                1660


Gly Ser Asp Gly Val Val Leu Ser Pro Asn Tyr Pro Gln Asn Tyr Thr 
1665                1670                1675                1680


Ser Gly Gln Ile Cys Leu Tyr Phe Val Thr Val Pro Lys Asp Tyr Val 
                1685                1690                1695


Val Phe Gly Gln Phe Ala Phe Phe His Thr Ala Leu Asn Asp Val Val 
            1700                1705                1710


Glu Val His Asp Gly His Ser Gln His Ser Arg Leu Leu Ser Ser Leu 
        1715                1720                1725


Ser Gly Ser His Thr Gly Glu Ser Leu Pro Leu Ala Thr Ser Asn Gln 
    1730                1735                1740


Val Leu Ile Lys Phe Ser Ala Lys Gly Leu Ala Pro Ala Arg Gly Phe 
1745                1750                1755                1760


His Phe Val Tyr Gln Ala Val Pro Arg Thr Ser Ala Thr Gln Cys Ser 
                1765                1770                1775


Ser Val Pro Glu Pro Arg Tyr Gly Lys Arg Leu Gly Ser Asp Phe Ser 
            1780                1785                1790


Val Gly Ala Ile Val Arg Phe Glu Cys Asn Ser Gly Tyr Ala Leu Gln 
        1795                1800                1805


Gly Ser Pro Glu Ile Glu Cys Leu Pro Val Pro Gly Ala Leu Ala Gln 
    1810                1815                1820


Trp Asn Val Ser Ala Pro Thr Cys Val Val Pro Cys Gly Gly Asn Leu 
1825                1830                1835                1840


Thr Glu Arg Arg Gly Thr Ile Leu Ser Pro Gly Phe Pro Glu Pro Tyr 
                1845                1850                1855


Leu Asn Ser Leu Asn Cys Val Trp Lys Ile Val Val Pro Glu Gly Ala 
            1860                1865                1870


Gly Ile Gln Ile Gln Val Val Ser Phe Val Thr Glu Gln Asn Trp Asp 
        1875                1880                1885


Ser Leu Glu Val Phe Asp Gly Ala Asp Asn Thr Val Thr Met Leu Gly 
    1890                1895                1900


Ser Phe Ser Gly Thr Thr Val Pro Ala Leu Leu Asn Ser Thr Ser Asn 
1905                1910                1915                1920


Gln Leu Tyr Leu His Phe Tyr Ser Asp Ile Ser Val Ser Ala Ala Gly 
                1925                1930                1935


Phe His Leu Glu Tyr Lys Thr Val Gly Leu Ser Ser Cys Pro Glu Pro 
            1940                1945                1950


Ala Val Pro Ser Asn Gly Val Lys Thr Gly Glu Arg Tyr Leu Val Asn 
        1955                1960                1965


Asp Val Val Ser Phe Gln Cys Glu Pro Gly Tyr Ala Leu Gln Gly His 
    1970                1975                1980


Ala His Ile Ser Cys Met Pro Gly Thr Val Arg Arg Trp Asn Tyr Pro 
1985                1990                1995                2000


Pro Pro Leu Cys Ile Ala Gln Cys Gly Gly Thr Val Glu Glu Met Glu 
                2005                2010                2015


Gly Val Ile Leu Ser Pro Gly Phe Pro Gly Asn Tyr Pro Ser Asn Met 
            2020                2025                2030


Asp Cys Ser Trp Lys Ile Ala Leu Pro Val Gly Phe Gly Ala His Ile 
        2035                2040                2045


Gln Phe Leu Asn Phe Ser Thr Glu Pro Asn His Asp Tyr Ile Glu Ile 
    2050                2055                2060


Arg Asn Gly Pro Tyr Glu Thr Ser Arg Met Met Gly Arg Phe Ser Gly 
2065                2070                2075                2080


Ser Glu Leu Pro Ser Ser Leu Leu Ser Thr Ser His Glu Thr Thr Val 
                2085                2090                2095


Tyr Phe His Ser Asp His Ser Gln Asn Arg Pro Gly Phe Lys Leu Glu 
            2100                2105                2110


Tyr Gln Ala Tyr Glu Leu Gln Glu Cys Pro Asp Pro Glu Pro Phe Ala 
        2115                2120                2125


Asn Gly Ile Val Arg Gly Ala Gly Tyr Asn Val Gly Gln Ser Val Thr 
    2130                2135                2140


Phe Glu Cys Leu Pro Gly Tyr Gln Leu Thr Gly His Pro Val Leu Thr 
2145                2150                2155                2160


Cys Gln His Gly Thr Asn Arg Asn Trp Asp His Pro Leu Pro Lys Cys 
                2165                2170                2175


Glu Val Pro Cys Gly Gly Asn Ile Thr Ser Ser Asn Gly Thr Val Tyr 
            2180                2185                2190


Ser Pro Gly Phe Pro Ser Pro Tyr Ser Ser Ser Gln Asp Cys Val Trp 
        2195                2200                2205


Leu Ile Thr Val Pro Ile Gly His Gly Val Arg Leu Asn Leu Ser Leu 
    2210                2215                2220


Leu Gln Thr Glu Pro Ser Gly Asp Phe Ile Thr Ile Trp Asp Gly Pro 
2225                2230                2235                2240


Gln Gln Thr Ala Pro Arg Leu Gly Val Phe Thr Arg Ser Met Ala Lys 
                2245                2250                2255


Lys Thr Val Gln Ser Ser Ser Asn Gln Val Leu Leu Lys Phe His Arg 
            2260                2265                2270


Asp Ala Ala Thr Gly Gly Ile Phe Ala Ile Ala Phe Ser Ala Tyr Pro 
        2275                2280                2285


Leu Thr Lys Cys Pro Pro Pro Thr Ile Leu Pro Asn Ala Glu Val Val 
    2290                2295                2300


Thr Glu Asn Glu Glu Phe Asn Ile Gly Asp Ile Val Arg Tyr Arg Cys 
2305                2310                2315                2320


Leu Pro Gly Phe Thr Leu Val Gly Asn Glu Ile Leu Thr Cys Lys Leu 
                2325                2330                2335


Gly Thr Tyr Leu Gln Phe Glu Gly Pro Pro Pro Ile Cys Glu Val His 
            2340                2345                2350


Cys Pro Thr Asn Glu Leu Leu Thr Asp Ser Thr Gly Val Ile Leu Ser 
        2355                2360                2365


Gln Ser Tyr Pro Gly Ser Tyr Pro Gln Phe Gln Thr Cys Ser Trp Leu 
    2370                2375                2380


Val Arg Val Glu Pro Asp Tyr Asn Ile Ser Leu Thr Val Glu Tyr Phe 
2385                2390                2395                2400


Leu Ser Glu Lys Gln Tyr Asp Glu Phe Glu Ile Phe Asp Gly Pro Ser 
                2405                2410                2415


Gly Gln Ser Pro Leu Leu Lys Ala Leu Ser Gly Asn Tyr Ser Ala Pro 
            2420                2425                2430


Leu Ile Val Thr Ser Ser Ser Asn Ser Val Tyr Leu Arg Trp Ser Ser 
        2435                2440                2445


Asp His Ala Tyr Asn Arg Lys Gly Phe Lys Ile Arg Tyr Ser Ala Pro 
    2450                2455                2460


Tyr Cys Ser Leu Pro Arg Ala Pro Leu His Gly Phe Ile Leu Gly Gln 
2465                2470                2475                2480


Thr Ser Thr Gln Pro Gly Gly Ser Ile His Phe Gly Cys Asn Ala Gly 
                2485                2490                2495


Tyr Arg Leu Val Gly His Ser Met Ala Ile Cys Thr Arg His Pro Gln 
            2500                2505                2510


Gly Tyr His Leu Trp Ser Glu Ala Ile Pro Leu Cys Gln Ala Leu Ser 
        2515                2520                2525


Cys Gly Leu Pro Glu Ala Pro Lys Asn Gly Met Val Phe Gly Lys Glu 
    2530                2535                2540


Tyr Thr Val Gly Thr Lys Ala Met Tyr Ser Cys Ser Glu Gly Tyr His 
2545                2550                2555                2560


Leu Gln Ala Gly Ala Glu Ala Thr Ala Glu Cys Leu Asp Thr Gly Leu 
                2565                2570                2575


Trp Ser Asn Arg Asn Val Pro Pro Gln Cys Val Pro Val Thr Cys Pro 
            2580                2585                2590


Asp Val Ser Ser Ile Ser Val Glu His Gly Arg Trp Arg Leu Ile Phe 
        2595                2600                2605


Glu Thr Gln Tyr Gln Phe Gln Ala Gln Leu Met Leu Ile Cys Asp Pro 
    2610                2615                2620


Gly Tyr Tyr Tyr Thr Gly Gln Arg Val Ile Arg Cys Gln Ala Asn Gly 
2625                2630                2635                2640


Lys Trp Ser Leu Gly Asp Ser Thr Pro Thr Cys Arg Ile Ile Ser Cys 
                2645                2650                2655


Gly Glu Leu Pro Ile Pro Pro Asn Gly His Arg Ile Gly Thr Leu Ser 
            2660                2665                2670


Val Tyr Gly Ala Thr Ala Ile Phe Ser Cys Asn Ser Gly Tyr Thr Leu 
        2675                2680                2685


Val Gly Ser Arg Val Arg Glu Cys Met Ala Asn Gly Leu Trp Ser Gly 
    2690                2695                2700


Ser Glu Val Arg Cys Leu Ala Thr Gln Thr Lys Leu His Ser Ile Phe 
2705                2710                2715                2720


Tyr Lys Leu Leu Phe Asp Val Leu Ser Ser Pro Ser Leu Thr Lys Ala 
                2725                2730                2735


Gly His Cys Gly Thr Pro Glu Pro Ile Val Asn Gly His Ile Asn Gly 
            2740                2745                2750


Glu Asn Tyr Ser Tyr Arg Gly Ser Val Val Tyr Gln Cys Asn Ala Gly 
        2755                2760                2765


Phe Arg Leu Ile Gly Met Ser Val Arg Ile Cys Gln Gln Asp His His 
    2770                2775                2780


Trp Ser Gly Lys Thr Pro Phe Cys Val Pro Ile Thr Cys Gly His Pro 
2785                2790                2795                2800


Gly Asn Pro Val Asn Gly Leu Thr Gln Gly Asn Gln Phe Asn Leu Asn 
                2805                2810                2815


Asp Val Val Lys Phe Val Cys Asn Pro Gly Tyr Met Ala Glu Gly Ala 
            2820                2825                2830


Ala Arg Ser Gln Cys Leu Ala Ser Gly Gln Trp Ser Asp Met Leu Pro 
        2835                2840                2845


Thr Cys Arg Ile Ile Asn Cys Thr Asp Pro Gly His Gln Glu Asn Ser 
    2850                2855                2860


Val Arg Gln Val His Ala Ser Gly Pro His Arg Phe Ser Phe Gly Thr 
2865                2870                2875                2880


Thr Val Ser Tyr Arg Cys Asn His Gly Phe Tyr Leu Leu Gly Thr Pro 
                2885                2890                2895


Val Leu Ser Cys Gln Gly Asp Gly Thr Trp Asp Arg Pro Arg Pro Gln 
            2900                2905                2910


Cys Leu Leu Val Ser Cys Gly His Pro Gly Ser Pro Pro His Ser Gln 
        2915                2920                2925


Met Ser Gly Asp Ser Tyr Thr Val Gly Ala Val Val Arg Tyr Ser Cys 
    2930                2935                2940


Ile Gly Lys Arg Thr Leu Val Gly Asn Ser Thr Arg Met Cys Gly Leu 
2945                2950                2955                2960


Asp Gly His Trp Thr Gly Ser Leu Pro His Cys Ser Gly Thr Ser Val 
                2965                2970                2975


Gly Val Cys Gly Asp Pro Gly Ile Pro Ala His Gly Ile Arg Leu Gly 
            2980                2985                2990


Asp Ser Phe Asp Pro Gly Thr Val Met Arg Phe Ser Cys Glu Ala Gly 
        2995                3000                3005


His Val Leu Arg Gly Ser Ser Glu Arg Thr Cys Gln Ala Asn Gly Ser 
    3010                3015                3020


Trp Ser Gly Ser Gln Pro Glu Cys Gly Val Ile Ser Cys Gly Asn Pro 
3025                3030                3035                3040


Gly Thr Pro Ser Asn Ala Arg Val Val Phe Ser Asp Gly Leu Val Phe 
                3045                3050                3055


Ser Ser Ser Ile Val Tyr Glu Cys Arg Glu Gly Tyr Tyr Ala Thr Gly 
            3060                3065                3070


Leu Leu Ser Arg His Cys Ser Val Asn Gly Thr Trp Thr Gly Ser Asp 
        3075                3080                3085


Pro Glu Cys Leu Val Ile Asn Cys Gly Asp Pro Gly Ile Pro Ala Asn 
    3090                3095                3100


Gly Leu Arg Leu Gly Asn Asp Phe Arg Tyr Asn Lys Thr Val Thr Tyr 
3105                3110                3115                3120


Gln Cys Val Pro Gly Tyr Met Met Glu Ser His Arg Val Ser Val Leu 
                3125                3130                3135


Ser Cys Thr Lys Asp Arg Thr Trp Asn Gly Thr Lys Pro Val Cys Lys 
            3140                3145                3150


Ala Leu Met Cys Lys Pro Pro Pro Leu Ile Pro Asn Gly Lys Val Val 
        3155                3160                3165


Gly Ser Asp Phe Met Trp Gly Ser Ser Val Thr Tyr Ala Cys Leu Glu 
    3170                3175                3180


Gly Tyr Gln Leu Ser Leu Pro Ala Val Phe Thr Cys Glu Gly Asn Gly 
3185                3190                3195                3200


Ser Trp Thr Gly Glu Leu Pro Gln Cys Phe Pro Val Phe Cys Gly Asp 
                3205                3210                3215


Pro Gly Val Pro Ser Arg Gly Arg Arg Glu Asp Arg Gly Phe Ser Tyr 
            3220                3225                3230


Arg Ser Ser Val Ser Phe Ser Cys His Pro Pro Leu Val Leu Val Gly 
        3235                3240                3245


Ser Pro Arg Arg Phe Cys Gln Ser Asp Gly Thr Trp Ser Gly Thr Gln 
    3250                3255                3260


Pro Ser Cys Ile Asp Pro Thr Leu Thr Thr Cys Ala Asp Pro Gly Val 
3265                3270                3275                3280


Pro Gln Phe Gly Ile Gln Asn Asn Ser Gln Gly Tyr Gln Val Gly Ser 
                3285                3290                3295


Thr Val Leu Phe Arg Cys Gln Lys Gly Tyr Leu Leu Gln Gly Ser Thr 
            3300                3305                3310


Thr Arg Thr Cys Leu Pro Asn Leu Thr Trp Ser Gly Thr Pro Pro Asp 
        3315                3320                3325


Cys Val Pro His His Cys Arg Gln Pro Glu Thr Pro Thr His Ala Asn 
    3330                3335                3340


Val Gly Ala Leu Asp Leu Pro Ser Met Gly Tyr Thr Leu Ile Tyr Ser 
3345                3350                3355                3360


Cys Gln Glu Gly Phe Ser Leu Lys Gly Gly Ser Glu His Arg Thr Cys 
                3365                3370                3375


Lys Ala Asp Gly Ser Trp Thr Gly Lys Pro Pro Ile Cys Leu Glu Val 
            3380                3385                3390


Arg Pro Ser Gly Arg Pro Ile Asn Thr Ala Arg Glu Pro Pro Leu Thr 
        3395                3400                3405


Gln Ala Leu Ile Pro Gly Asp Val Phe Ala Lys Asn Ser Leu Trp Lys 
    3410                3415                3420


Gly Ala Tyr Glu Tyr Gln Gly Lys Lys Gln Pro Ala Met Leu Arg Val 
3425                3430                3435                3440


Thr Gly Phe Gln Val Ala Asn Ser Lys Val Asn Ala Thr Met Ile Asp 
                3445                3450                3455


His Ser Gly Val Glu Leu His Leu Ala Gly Thr Tyr Lys Lys Glu Asp 
            3460                3465                3470


Phe His Leu Leu Leu Gln Val Tyr Gln Ile Thr Gly Pro Val Glu Ile 
        3475                3480                3485


Phe Met Asn Lys Phe Lys Asp Asp His Trp Ala Leu Asp Gly His Val 
    3490                3495                3500


Ser Ser Glu Ser Ser Gly Ala Thr Phe Ile Tyr Gln Gly Ser Val Lys 
3505                3510                3515                3520


Gly Gln Gly Phe Gly Gln Phe Gly Phe Gln Arg Leu Asp Leu Arg Leu 
                3525                3530                3535


Leu Glu Ser Asp Pro Glu Ser Ile Gly Arg His Phe Ala Ser Asn Ser 
            3540                3545                3550


Ser Ser Val Ala Ala Ala Ile Leu Val Pro Phe Ile Ala Leu Ile Ile 
        3555                3560                3565


Ala Gly Phe Val Leu Tyr Leu Tyr Lys His Arg Arg Arg Pro Lys Val 
    3570                3575                3580


Pro Phe Asn Gly Tyr Ala Gly His Glu Asn Thr Asn Val Arg Ala Thr 
3585                3590                3595                3600


Phe Glu Asn Pro Met Tyr Asp Arg Asn Ile Gln Pro Thr Asp Ile Met 
                3605                3610                3615


Ala Ser Glu Ala Glu Phe Thr Val Ser Thr Val Cys Thr Ala Val 
            3620                3625                3630


<210>  1794
<211>  13118
<212>  DNA
<213>  Homo sapiens

<400>  1794
tcctgggatg gggtaggagg ctattgtgaa tgaggctcat aagcatcgcc cccggcccta     60

gatggcaagt tcaaagccac cacccaagat cagctggcca gaactgcacg ttccaactgc    120

acggtcccaa tgggacagtt gagagcccag ggttcccata tggctacccc aattacgcca    180

actgcacgtg gaccatcacc gcggaagagc agcacagaat ccagcttgtg ttccagtcct    240

ttgccctgga agaggacttt gatgtcctgt cggtgtttga tggtccaccc cagccagaga    300

atctgcgtac gaggctcaca ggctttcagc tgccagccac cattgttagt gcagccacca    360

ccctctctct gcgcctcatc agcgactatg cagtcagtgc ccaaggcttc cacgccacct    420

atgaagttct ccccagccac acatgtggga acccagggag gctgcccaat ggcatccagc    480

agggttcaac cttcaacctc ggtgacaagg tccgctacag ctgcaacctt ggcttcttcc    540

tggagggcca cgccgtgctc acctgccacg ctggctctga gaacagcgcc acgtgggact    600

tccccctgcc ttcctgcaga gctgatgatg cctgtggtgg gaccctgcgg ggccagagtg    660

gcatcatctc cagcccccac ttcccctcgg agtaccataa caatgccgac tgcacatgga    720

ccatcctggc tgagctgggg gacaccatcg ccctggtgtt tattgacttc cagctggagg    780

atggttacga ctttctggaa gtcactggga cagaaggctc ctccctctgg ttcaccggag    840

ccagcctccc agcccccgtt atcagcagca agaactggct gcgactgcac ttcacatcgg    900

atggcaacca ccggcagcgc ggattcagtg cccaatacca agtcaagaag caaattgagt    960

tgaagtctcg aggtgtgaag ctgatgccca gcaaagacaa cagccagaag acgtctgtgt   1020

taactcaggt tggtgtgtcc caaggacata atatgtgtcc agaccctggc atacccgaaa   1080

ggggcaaaag actaggctcg gatttcaggt taggatccag cgtccagttc acctgcaacg   1140

agggctatga cctgcaaggg tccaagcgga tcacctgtat gaaagtgagc gacatgtttg   1200

cggcctggag cgaccacagg ccagtctgcc gagcccgcat gtgtgatgcc caccttcgag   1260

gcccctcggg catcatcacc tcccccaatt tccccattca gtatgacaac aatgcacact   1320

gtgtgtggat catcacagca ctcaacccct ccaaggtgat caagctcgcc tttgaggagt   1380

ttgatttgga gaggggctat gacaccctga cggtcggtga tggtggtcag gatggggacc   1440

agaagacagt tctctacatc ctgacaggta catcggtccc ggatctcatt gtcagcacca   1500

atcatcaaat gtggctcctc ttccagactg atggcagtgg cagttccctg ggattcaagg   1560

cttcttatga agagatcgag cagggcagtt gcggtgaccc tggcatacct gcatatggcc   1620

ggagggaagg ctcccggttt caccacggtg acacactcaa gtttgagtgc cagcccgcct   1680

ttgagctggt gggacagaag gcaatcacat gccaaaagaa taaccaatgg tcggctaaga   1740

agccaggctg cgtgttctcc tgcttcttca acttcaccag cccgtctggg gttgtcctgt   1800

ctcccaacta cccagaggac tatggcaacc acctccactg tgtctggctc atcctggcca   1860

ggcctgagag ccgcatccac ctggccttca acgacattga cgtggagcct cagtttgatt   1920

tcctggtcat caaggatggg gccaccgccg aggcgcccgt cctgggcacc ttctcaggaa   1980

accagcttcc ctcctccatc acaagcagtg gccacgtggc ccgtctcgag ttccagactg   2040

accactccac agggaagagg ggcttcaaca tcacttttac caccttccga cacaacgagt   2100

gcccggatcc tggcgttcca gtaaatggca aacggtttgg ggacagcctc cagctgggca   2160

gctccatctc cttcctctgt gatgaaggct tccttgggac tcagggctca gagaccatca   2220

cctgcgtcct gaaggagggc agcgtggtct ggaacagcgc tgtgctgcgg tgtgaagctc   2280

cctgtggtgg tcacctgact tcgcccagcg gcaccatcct ctctccgggc tggcctggct   2340

tctacaagga tgccttgagc tgtgcctggg tgattgaggc ccagccaggc taccccatca   2400

aaatcacctt cgacagattc aaaaccgagg tcaactatga caccctggaa gtacgcgatg   2460

ggcggactta ctcagcgccc ttgatcgggg tttaccacgg gacccaggtt ccccagttcc   2520

tcatcagcac cagcaactac ctctacctcc tcttctctac cgacaagagt cactcggaca   2580

tcggcttcca gctccgctat gagactataa cactgcagtc agaccactgt ctggatccag   2640

gaatcccagt aaatggacag cgtcatggga atgacttcta cgtgggcgcg ctggtgacct   2700

tcagctgtga ctcgggctac acattaagtg acggggagcc tctggagtgt gagcccaact   2760

tccagtggag ccgggccctg cccagttgtg aagctctctg tggtggcttc attcaaggct   2820

ccagtgggac catcttgtcg ccagggttcc ctgacttcta ccccaacaac ttgaactgca   2880

cctggattat cgaaacatct catggcaagg gtgtgttctt cactttccac accttccacc   2940

tggaaagtgg ccatgactac ctcctcatca ctgagaacgg cagcttcacc cagcccctga   3000

ggcagctaac tggatctcgg ctgccagctc ccatcagcgc tgggctctat ggcaacttca   3060

ctgcccaggt ccgcttcatc tctgatttct ccatgtcata tgaaggattc aacatcacct   3120

tctcagagta cgacttggag ccctgtgagg agcccgaggt cccagcctac agcatccgga   3180

agggcttgca gtttggcgtg ggcgacacct tgaccttctc ctgcttcccc gggtaccgtc   3240

tggagggcac cgcccgcatc acgtgcctgg ggggcagacg gcgcctgtgg agctcgcctc   3300

tgccaaggtg tgttgctgag tgtgggaatt cagtcacagg cactcagggt actttgctgt   3360

cccccaactt tcctgtgaac tacaataaca atcatgaatg catctactcc atccagaccc   3420

agccagggaa gggaattcag ctgaaagcca gggcattcga actctccgaa ggagatgtcc   3480

tcaaggttta tgatggcaac aacaactccg cccgtttgct gggagttttt agccattctg   3540

agatgatggg ggtgactttg aacagcacat ccagcagtct gtggcttgat ttcatcactg   3600

atgctgaaaa caccagcaag ggctttgaac tgcacttttc cagctttgaa ctcatcaaat   3660

gtgaggaccc aggaaccccc aagtttggct acaaggttca tgatgaaggt cattttgcag   3720

ggagctccgt gtccttcagc tgtgaccctg gatacagcct gcggggtagt gaggagctgc   3780

tgtgtctgag tggagagcgc cggacctggg accggcctct gcccacctgt gtcgccgagt   3840

gtggagggac agtgagagga gaggtgtcgg ggcaggtgct gtcacccggg tatccagctc   3900

cctatgaaca caatctcaac tgcatctgga ccatcgaagc agaggccggc tgcaccattg   3960

ggctacactt cctggtgttt gacacagagg aggttcacga cgtgctgcgc atctgggatg   4020

ggcctgtgga gagcggggtt ctgctgaagg agctgagtgg cccggccctg cccaaggacc   4080

tgcatagcac cttcaactcg gtcgtcctgc agttcagcac tgacttcttc accagcaagc   4140

agggctttgc cattcaattt tcagtgtcca cagcaacgtc ctgcaatgac cctgggatcc   4200

cgcagaatgg gagtcggagt ggtgacagtt gggaagccgg cgactccaca gtgttccagt   4260

gtgaccctgg ctacgcgctg cagggaagtg cagagatcag ctgtgtgaag atcgagaaca   4320

ggttcttctg gcagcccagc ccgccaacat gcatcgctcc ctgcggggga gacctgacag   4380

gaccatctgg agtcatcctc tcaccaaatt acccagaacc ctacccgcca ggcaaggagt   4440

gtgactggaa agtgaccgtc tcaccagact acgtcatcgc cctggtattt aacatcttta   4500

acctggagcc tggctatgac ttcctccata tctacgacgg acgggactct ctcagccctc   4560

tcataggaag cttctatggc tcccagctcc caggccgcat tgaaagcagc agcaacagcc   4620

tcttcctcgc cttccgcagc gatgcatctg tgagcaatgc tggcttcgtc attgactata   4680

cagaaaaccc gcgggagtca tgttttgatc ctggttccat caagaacggc acacgggtgg   4740

ggtccgacct gaagctgggc tcctccgtca cctactactg ccacgggggc tacgaagttg   4800

agggcacctc gaccctgagc tgcatcctgg ggcctgatgg gaagcccgtg tggaacaatc   4860

cccggccagt ctgcacagcc ccctgtgggg gacagtatgt gggttcggac ggagtggtct   4920

tgtcccccaa ctacccccag aactacacca gtggacagat ctgcttgtat tttgttactg   4980

tgcccaagga ctatgtggtg tttggccagt tcgccttctt tcacacggcc ctcaacgacg   5040

tggtggaggt tcacgacggc cacagccagc actcgcggct cctcagctcc ctctcgggct   5100

cccatacagg agaatcactg cccttggcca cctccaatca agttctcatt aagttcagcg   5160

ccaaaggcct cgcaccagcc agaggcttcc actttgtcta ccaagcggtt cctcgaacca   5220

gcgccacgca gtgcagctct gtgccggaac cccgctatgg caagaggctg ggcagtgact   5280

tctcggtggg ggccatcgtc cgcttcgaat gcaactccgg ctatgccctg caggggtcgc   5340

cagagatcga gtgcctccct gtgcctgggg ccttggccca atggaatgtc tcagcgccca   5400

cgtgtgtggt gccgtgtgga ggcaacctca cagagcgcag gggcaccatc ctgtcccctg   5460

gcttcccaga gccgtacctc aacagcctca actgtgtgtg gaagatcgtg gtccccgaag   5520

gcgctggcat ccagatccaa gttgtcagtt ttgtgacaga gcagaactgg gactcgctgg   5580

aagtatttga tggtgcagat aacactgtaa ccatgctggg gagtttctca ggaacaaccg   5640

tgcctgccct tctgaacagc acctccaacc agctctacct tcatttctac tcagatatca   5700

gcgtatctgc agctggcttc cacttggagt acaaaacggt gggcctgagc agttgtccgg   5760

aacctgctgt gcccagtaac ggggtgaaga ctggcgagcg ctacttggtg aatgatgtgg   5820

tgtctttcca gtgtgagccg ggatatgccc tccagggcca cgcccacatc tcctgcatgc   5880

ccggaacagt gcggcgatgg aactaccctc ctccactctg tattgcacag tgtgggggaa   5940

cagtggagga gatggagggg gtgatcctga gccccggctt cccaggcaac taccccagta   6000

acatggactg ctcctggaaa atagcactgc ccgtgggctt tggagctcac atccagttcc   6060

tgaacttctc caccgagccc aaccacgact acatagaaat ccggaatggc ccctatgaga   6120

ccagccgcat gatgggaaga ttcagtggaa gcgagcttcc aagctccctc ctctccacgt   6180

cccacgagac caccgtgtat ttccacagcg accactccca gaatcggcca ggattcaagc   6240

tggagtatca ggatttgact tactcccacc agatttcttc cttcctgaga ggttttgatc   6300

tctcggagtt ggaaagaacc aactcaactc ctcccgtcgc cgcttcctat gtctgggatc   6360

ttgatcctgg ttgtgaagcc tatgaacttc aagagtgccc agacccagag ccctttgcca   6420

atggcattgt gaggggagct ggctacaacg tgggacaatc agtgaccttc gagtgcctcc   6480

cggggtatca attgactggc caccctgtcc tcacgtgtca acatggcacc aaccggaact   6540

gggaccaccc cctgcccaag tgtgaagtcc cttgtggcgg gaacatcact tcttccaacg   6600

gcactgtgta ctccccgggg ttccctagcc cgtactccag ctcccaggac tgtgtctggc   6660

tgatcaccgt gcccattggc catggcgtcc gcctcaacct cagcctgctg cagacagagc   6720

cctctggaga tttcatcacc atctgggatg ggccacagca aacagcacca cggctcggcg   6780

tcttcacccg gagcatggcc aagaaaacag tgcagagttc atccaaccag gtcctgctca   6840

agttccaccg tgatgcagcc acagggggga tcttcgccat agctttctcc gcttatccac   6900

tcaccaaatg ccctcctccc accatcctcc ccaacgccga agtcgtcaca gagaatgaag   6960

aattcaatat aggtgacatc gtacgctaca gatgcctccc tggctttacc ttagtgggga   7020

atgaaattct gacctgcaaa cttggaacct acctgcagtt tgaaggacca cccccgatat   7080

gtgaagtgca ctgtccaaca aatgagcttc tgacagactc cacaggcgtg atcctgagcc   7140

agagctaccc tggaagctat ccccagttcc agacctgctc ttggctggtg agagtggagc   7200

ccgactataa catctccctc acagtggagt acttcctcag cgagaagcaa tatgatgagt   7260

ttgagatttt tgatggtcca tcaggacaga gtcctctgct gaaagccctc agtgggaatt   7320

actcagctcc cctgattgtc accagctcaa gcaactctgt gtacctgcgt tggtcatctg   7380

atcacgccta caatcggaag ggcttcaaga tccgctattc agccccttac tgcagcctgc   7440

ccagggctcc actccatggc ttcatcctag gccagaccag cacccagccc gggggctcca   7500

tccactttgg ctgcaacgcc ggctaccgcc tggtgggaca cagcatggcc atctgtaccc   7560

ggcaccccca gggctaccac ctgtggagcg aagccatccc tctctgtcaa gctctttcct   7620

gtgggcttcc tgaggccccc aagaatggaa tggtgtttgg caaggagtac acagtgggaa   7680

ccaaggccat gtacagctgc agtgaaggct accacctcca ggcaggcgct gaggccactg   7740

cagagtgtct ggacacaggc ctatggagca accgcaatgt cccaccacag tgtgtccctg   7800

tgacttgtcc tgatgtcagt agcatcagcg tggagcatgg ccgatggagg cttatctttg   7860

agacacagta tcagttccag gcccagctga tgctcatctg tgaccctggc tactactata   7920

ctggccaaag ggtcatccgc tgtcaggcca atggcaaatg gagcctcggg gactctacgc   7980

ccacctgccg aatcatctcc tgtggagagc tcccgattcc ccccaatggc caccgcatcg   8040

gaacactgtc tgtctacggg gcaacagcca tcttctcctg caattccgga tacacactgg   8100

tgggctccag ggtgcgtgag tgcatggcca atgggctctg gagtggctct gaagtccgct   8160

gccttgctgg acactgtggg actcctgagc ccattgtcaa cggacacatc aatggggaga   8220

actacagcta ccggggcagt gtggtgtacc aatgcaatgc tggcttccgc ctgatcggca   8280

tgtctgtgcg catctgccag caggatcatc actggtcggg caagacccct ttctgtgtgc   8340

tggtgtcctg tggccatccg ggctccccgc ctcactccca gatgtctgga gacagttata   8400

ctgtgggagc agtggtgcgg tacagctgca tcggcaagcg tactctggtg ggaaacagca   8460

cccgcatgtg tgggctggat ggacactgga ctggctccct ccctcactgc tcaggaacca   8520

gcgtgggagt ttgcggtgac cctgggatcc cggctcatgg catccgtttg ggggacagct   8580

ttgatccagg cactgtgatg cgcttcagct gtgaagctgg ccacgtgctc cggggatcgt   8640

cagagcgcac ctgtcaagcc aatggctcgt ggagcggctc gcagcctgag tgtggagtga   8700

tctcttgtgg gaaccctggg actccaagta atgcccgagt tgtgttcagt gatggcctgg   8760

ttttctccag ctctatcgtc tatgagtgcc gggaaggata ctacgccaca ggcctgctca   8820

gccgtcactg ctcggtcaat ggtacctgga caggcagtga ccctgagtgc ctcgtcataa   8880

actgtggtga ccctgggatt ccagccaatg gccttcggct gggcaatgac ttcaggtaca   8940

acaaaactgt gacatatcag tgtgtccctg gctatatgat ggagtcacat agagtatctg   9000

tgctgagctg caccaaggac cggacatgga atggaaccaa gcccgtctgc aaagctctca   9060

tgtgcaagcc acctccgctc atccccaatg ggaaggtggt ggggtctgac ttcatgtggg   9120

gctcaagtgt gacttatgcc tgcctggagg ggtaccagct ctccctgccc gcggtgttca   9180

cctgtgaggg aaatgggtcc tggaccggag agctgcctca gtgtttccct gtgttctgcg   9240

gggatcctgg tgtcccgtcc cgtgggagga gagaggaccg aggcttctcc tacaggtcat   9300

ctgtctcctt ctcctgccat ccccctctgg tgctggtggg ctctccacgc aggttttgcc   9360

agtcagatgg gacatggagt ggcacccagc ccagctgcat agatccgacc ctgaccacgt   9420

gtgcggaccc tggtgtgcca cagtttggga tacagaacaa ttctcagggc taccaggttg   9480

gaagcacagt cctcttccgt tgtcaaaaag gctacctgct tcagggctcc accaccagga   9540

cctgcctccc aaacctgacc tggagtggaa ccccacctga ctgtgtcccc caccactgca   9600

ggcagccaga gacgccaacg catgccaacg tcggggccct ggatttgccc tccatgggct   9660

acacgctcat ctactcctgc caggagggct tctccctcaa gggtggctcc gagcaccgca   9720

cctgcaaggc ggatggcagc tggacaggca agccgcccat ctgcctggag gtccggccca   9780

gtgggagacc catcaacact gcccgggagc caccgctcac ccaagccttg attcctgggg   9840

atgtttttgc caagaattcc ctgtggaaag gggcctatga ataccagggg aagaagcagc   9900

cagccatgct cagagtgact ggcttccaag ttgccaacag caaggtcaat gccaccatga   9960

tcgaccacag tggcgtggag ctgcacttgg ctggaactta caagaaagaa gattttcatc  10020

tcctactcca ggtgtaccag attacagggc ctgtggagat ctttatgaat aagttcaaag  10080

atgatcactg ggctttagat ggccatgtct cgtcagagtc ctccggagcc accttcatct  10140

accaaggctc tgtcaagggc caaggctttg ggcagttcgg ctttcaaaga ctggacctca  10200

ggctgctgga gtcagacccc gagtccattg gccgccactt tgcttccaac agcagctcag  10260

tggcagccgc gatcctggtg cctttcatcg ccctcattat tgcgggcttc gtgctctatc  10320

tctacaagca caggagaaga cccaaagttc ctttcaatgg ctatgctggc cacgagaaca  10380

ccaatgttcg ggccacattt gagaacccaa tgtacgaccg caacatccag cccacagaca  10440

tcatggccag cgaggcggag ttcacagtca gcacagtgtg cacagcagta tagccacccg  10500

gcctggccgc caccaccgcc accgagagcc ccgcctccag cagccgttcc ccagggggca  10560

ggaagtaggc tcccctgagc acagtgccca gtgcccatct tcgttcgtct ccttgcctgt  10620

gtctgctact gctgggactc aggccctcgc cctgccgcca tctatgccag ttaccctgga  10680

gaggactcct gccgtgtcct gaaaaggcag aaaaggaaga ggggctgcag acagaggaag  10740

aaagtttatg gatttaaaat agcaaagcaa cttgtggatc tgtgtgtgtg tgtgtgtgta  10800

tgggcctgat cacacacaaa cacacacacc tctccttcat tcacgtccta tggaagagac  10860

cataaaggct tcaaaactag aagtgcgcat gaaggatgct tcatgccctg ttccccacac  10920

agagaagaga tgaagagggg gaggtacggt cagctttcaa aacaatatgc cccccgccca  10980

tcccatgtgt gaggacatgg tgactcggtg actgtaacag taggacacat cccatcatgc  11040

ggtcagagtg cagaaacccg gtcagcgtgc agaaaccagc tgtctgctga tgaacggccc  11100

atctgcacag cggcagcaag gattacccca agggcaggaa aaaagtcttt ggaaatagat  11160

tgaaaatcag tttctttatt tttttcaaac actgttttat tgagttctaa acccagtgga  11220

ttaaaaagtc atttgggtcc tgggaagcac tgggaaagaa gggagagccg gggaggatag  11280

ggcaggagtc tggccaggag cccaaggtca agtctggctg tcaactgaca aagagaagag  11340

aagacaagtc tgtggcccag acaggatgcc aagtctgggg gcagcagcag ggtccttgag  11400

agaacagggg agcaagcctg ccccagtacc caaaaaacaa tggctatcat gtactggggt  11460

tattctctgt gcctgacact ttacctgtag tatttctagt ctgcacaata acaccaaaat  11520

gtaggatttg ttattcccct ttgacagatg agaaaacaga agcctgcaaa ggtaaagaca  11580

gagttaggaa gtgtggagtc agaatgcaaa cccagatcag tctgccccaa agtccactac  11640

accagctgcc agaaaccctg ttctagaagg ggcagctaag aagggaggag ccgatgaatc  11700

tctacagtag cactgtggcc aggtctggaa agccaggcaa gacacctgtg tgtcctatct  11760

gggttctgct gtctccgcgt aggcagcttc ggggcaagga ttcaactccc caggcctccc  11820

acggttggtg ctggctcctt ggctcccagc agccgctgac catagccagc aaaagacctg  11880

gcaggtcctg aatcaaaaca acagagtggc tgaaagtcac acctctccag ctccttgcga  11940

gtgggtttga ttgattttga cagctatatc atgcttgggt cgttcatgaa ttccatgaga  12000

attgttggga agttcatgag tttaggaatc aaagtatagc atttagggcc actttctctg  12060

tcctcgggaa ggcccccaca agcttaagcc cctgtatacg tgtgacatgc tggcctcaga  12120

gattcatgtc acatattgaa atagcaaata gaaatgtgca ggagcggagg gacagcgaca  12180

cctggttctt aagcaaattc tagattggaa caattagaag atctgactga tgttaagagt  12240

ggccagagga aagtgagagg cgtccatttc cagcagacac aatggaggct gacagaggca  12300

ggagcctacc cctggccaca ccacctctgg gacacggcac ccccctgggc ctggagggag  12360

agggccaatc cagacacact cacactctca tctctttcct tggctggaaa caagtgcagg  12420

aagctcccct cccaatttct tatgctccct tcccccttac actcctctcc ttcgactgct  12480

cccttccccc ttcttatgcc cctctcagac cacccagcgg atgcctattc ccgcccccca  12540

cccctcccct gcgtctcctt gtaaagttcc atgagatgct cgaggagcac ctgctggtgg  12600

ggcacccagc actctgctgg gcatcaccct ccgcacccct gacatttctc tccacctcca  12660

gaggcttgga agggaacagg gcagatgagg cccttcaccc accatctacg ccatataccc  12720

atcaccatcc catgaggaaa aaaaaaaaag taaaacaaag acaaaaaaaa tcttttgtac  12780

agagatatat ttttattata caaagtttgt acagtaccaa aaaagaaaaa aaaaaaggtg  12840

taaatttttt tttcattatt gtaggtaaac ggtagtggaa gccttttttg taaatgtaat  12900

aaaatgtata aatatggttt tcagaaaaca tcaagtgctg taaatatgta atctacacac  12960

cttcttggct tgtctgcagt atatacattt aatttatctg tctctgtata tgaggcttcc  13020

ccctggggtc ctgcattatg gtactttcct gaatttgaaa gcaattttaa attttttgaa  13080

ttcaaataaa atataaattt ttgcattggt tttcttac                          13118


<210>  1795
<211>  3487
<212>  PRT
<213>  Homo sapiens

<400>  1795

Met Arg Leu Ile Ser Ile Ala Pro Gly Pro Arg Trp Gln Val Gln Ser 
1               5                   10                  15


His His Pro Arg Ser Ala Gly Gln Asn Cys Thr Phe Gln Leu His Gly 
            20                  25                  30


Pro Asn Gly Thr Val Glu Ser Pro Gly Phe Pro Tyr Gly Tyr Pro Asn 
        35                  40                  45


Tyr Ala Asn Cys Thr Trp Thr Ile Thr Ala Glu Glu Gln His Arg Ile 
    50                  55                  60


Gln Leu Val Phe Gln Ser Phe Ala Leu Glu Glu Asp Phe Asp Val Leu 
65                  70                  75                  80


Ser Val Phe Asp Gly Pro Pro Gln Pro Glu Asn Leu Arg Thr Arg Leu 
                85                  90                  95


Thr Gly Phe Gln Leu Pro Ala Thr Ile Val Ser Ala Ala Thr Thr Leu 
            100                 105                 110


Ser Leu Arg Leu Ile Ser Asp Tyr Ala Val Ser Ala Gln Gly Phe His 
        115                 120                 125


Ala Thr Tyr Glu Val Leu Pro Ser His Thr Cys Gly Asn Pro Gly Arg 
    130                 135                 140


Leu Pro Asn Gly Ile Gln Gln Gly Ser Thr Phe Asn Leu Gly Asp Lys 
145                 150                 155                 160


Val Arg Tyr Ser Cys Asn Leu Gly Phe Phe Leu Glu Gly His Ala Val 
                165                 170                 175


Leu Thr Cys His Ala Gly Ser Glu Asn Ser Ala Thr Trp Asp Phe Pro 
            180                 185                 190


Leu Pro Ser Cys Arg Ala Asp Asp Ala Cys Gly Gly Thr Leu Arg Gly 
        195                 200                 205


Gln Ser Gly Ile Ile Ser Ser Pro His Phe Pro Ser Glu Tyr His Asn 
    210                 215                 220


Asn Ala Asp Cys Thr Trp Thr Ile Leu Ala Glu Leu Gly Asp Thr Ile 
225                 230                 235                 240


Ala Leu Val Phe Ile Asp Phe Gln Leu Glu Asp Gly Tyr Asp Phe Leu 
                245                 250                 255


Glu Val Thr Gly Thr Glu Gly Ser Ser Leu Trp Phe Thr Gly Ala Ser 
            260                 265                 270


Leu Pro Ala Pro Val Ile Ser Ser Lys Asn Trp Leu Arg Leu His Phe 
        275                 280                 285


Thr Ser Asp Gly Asn His Arg Gln Arg Gly Phe Ser Ala Gln Tyr Gln 
    290                 295                 300


Val Lys Lys Gln Ile Glu Leu Lys Ser Arg Gly Val Lys Leu Met Pro 
305                 310                 315                 320


Ser Lys Asp Asn Ser Gln Lys Thr Ser Val Leu Thr Gln Val Gly Val 
                325                 330                 335


Ser Gln Gly His Asn Met Cys Pro Asp Pro Gly Ile Pro Glu Arg Gly 
            340                 345                 350


Lys Arg Leu Gly Ser Asp Phe Arg Leu Gly Ser Ser Val Gln Phe Thr 
        355                 360                 365


Cys Asn Glu Gly Tyr Asp Leu Gln Gly Ser Lys Arg Ile Thr Cys Met 
    370                 375                 380


Lys Val Ser Asp Met Phe Ala Ala Trp Ser Asp His Arg Pro Val Cys 
385                 390                 395                 400


Arg Ala Arg Met Cys Asp Ala His Leu Arg Gly Pro Ser Gly Ile Ile 
                405                 410                 415


Thr Ser Pro Asn Phe Pro Ile Gln Tyr Asp Asn Asn Ala His Cys Val 
            420                 425                 430


Trp Ile Ile Thr Ala Leu Asn Pro Ser Lys Val Ile Lys Leu Ala Phe 
        435                 440                 445


Glu Glu Phe Asp Leu Glu Arg Gly Tyr Asp Thr Leu Thr Val Gly Asp 
    450                 455                 460


Gly Gly Gln Asp Gly Asp Gln Lys Thr Val Leu Tyr Ile Leu Thr Gly 
465                 470                 475                 480


Thr Ser Val Pro Asp Leu Ile Val Ser Thr Asn His Gln Met Trp Leu 
                485                 490                 495


Leu Phe Gln Thr Asp Gly Ser Gly Ser Ser Leu Gly Phe Lys Ala Ser 
            500                 505                 510


Tyr Glu Glu Ile Glu Gln Gly Ser Cys Gly Asp Pro Gly Ile Pro Ala 
        515                 520                 525


Tyr Gly Arg Arg Glu Gly Ser Arg Phe His His Gly Asp Thr Leu Lys 
    530                 535                 540


Phe Glu Cys Gln Pro Ala Phe Glu Leu Val Gly Gln Lys Ala Ile Thr 
545                 550                 555                 560


Cys Gln Lys Asn Asn Gln Trp Ser Ala Lys Lys Pro Gly Cys Val Phe 
                565                 570                 575


Ser Cys Phe Phe Asn Phe Thr Ser Pro Ser Gly Val Val Leu Ser Pro 
            580                 585                 590


Asn Tyr Pro Glu Asp Tyr Gly Asn His Leu His Cys Val Trp Leu Ile 
        595                 600                 605


Leu Ala Arg Pro Glu Ser Arg Ile His Leu Ala Phe Asn Asp Ile Asp 
    610                 615                 620


Val Glu Pro Gln Phe Asp Phe Leu Val Ile Lys Asp Gly Ala Thr Ala 
625                 630                 635                 640


Glu Ala Pro Val Leu Gly Thr Phe Ser Gly Asn Gln Leu Pro Ser Ser 
                645                 650                 655


Ile Thr Ser Ser Gly His Val Ala Arg Leu Glu Phe Gln Thr Asp His 
            660                 665                 670


Ser Thr Gly Lys Arg Gly Phe Asn Ile Thr Phe Thr Thr Phe Arg His 
        675                 680                 685


Asn Glu Cys Pro Asp Pro Gly Val Pro Val Asn Gly Lys Arg Phe Gly 
    690                 695                 700


Asp Ser Leu Gln Leu Gly Ser Ser Ile Ser Phe Leu Cys Asp Glu Gly 
705                 710                 715                 720


Phe Leu Gly Thr Gln Gly Ser Glu Thr Ile Thr Cys Val Leu Lys Glu 
                725                 730                 735


Gly Ser Val Val Trp Asn Ser Ala Val Leu Arg Cys Glu Ala Pro Cys 
            740                 745                 750


Gly Gly His Leu Thr Ser Pro Ser Gly Thr Ile Leu Ser Pro Gly Trp 
        755                 760                 765


Pro Gly Phe Tyr Lys Asp Ala Leu Ser Cys Ala Trp Val Ile Glu Ala 
    770                 775                 780


Gln Pro Gly Tyr Pro Ile Lys Ile Thr Phe Asp Arg Phe Lys Thr Glu 
785                 790                 795                 800


Val Asn Tyr Asp Thr Leu Glu Val Arg Asp Gly Arg Thr Tyr Ser Ala 
                805                 810                 815


Pro Leu Ile Gly Val Tyr His Gly Thr Gln Val Pro Gln Phe Leu Ile 
            820                 825                 830


Ser Thr Ser Asn Tyr Leu Tyr Leu Leu Phe Ser Thr Asp Lys Ser His 
        835                 840                 845


Ser Asp Ile Gly Phe Gln Leu Arg Tyr Glu Thr Ile Thr Leu Gln Ser 
    850                 855                 860


Asp His Cys Leu Asp Pro Gly Ile Pro Val Asn Gly Gln Arg His Gly 
865                 870                 875                 880


Asn Asp Phe Tyr Val Gly Ala Leu Val Thr Phe Ser Cys Asp Ser Gly 
                885                 890                 895


Tyr Thr Leu Ser Asp Gly Glu Pro Leu Glu Cys Glu Pro Asn Phe Gln 
            900                 905                 910


Trp Ser Arg Ala Leu Pro Ser Cys Glu Ala Leu Cys Gly Gly Phe Ile 
        915                 920                 925


Gln Gly Ser Ser Gly Thr Ile Leu Ser Pro Gly Phe Pro Asp Phe Tyr 
    930                 935                 940


Pro Asn Asn Leu Asn Cys Thr Trp Ile Ile Glu Thr Ser His Gly Lys 
945                 950                 955                 960


Gly Val Phe Phe Thr Phe His Thr Phe His Leu Glu Ser Gly His Asp 
                965                 970                 975


Tyr Leu Leu Ile Thr Glu Asn Gly Ser Phe Thr Gln Pro Leu Arg Gln 
            980                 985                 990


Leu Thr Gly Ser Arg Leu Pro Ala Pro Ile Ser Ala Gly Leu Tyr Gly 
        995                 1000                1005


Asn Phe Thr Ala Gln Val Arg Phe Ile Ser Asp Phe Ser Met Ser Tyr 
    1010                1015                1020


Glu Gly Phe Asn Ile Thr Phe Ser Glu Tyr Asp Leu Glu Pro Cys Glu 
1025                1030                1035                1040


Glu Pro Glu Val Pro Ala Tyr Ser Ile Arg Lys Gly Leu Gln Phe Gly 
                1045                1050                1055


Val Gly Asp Thr Leu Thr Phe Ser Cys Phe Pro Gly Tyr Arg Leu Glu 
            1060                1065                1070


Gly Thr Ala Arg Ile Thr Cys Leu Gly Gly Arg Arg Arg Leu Trp Ser 
        1075                1080                1085


Ser Pro Leu Pro Arg Cys Val Ala Glu Cys Gly Asn Ser Val Thr Gly 
    1090                1095                1100


Thr Gln Gly Thr Leu Leu Ser Pro Asn Phe Pro Val Asn Tyr Asn Asn 
1105                1110                1115                1120


Asn His Glu Cys Ile Tyr Ser Ile Gln Thr Gln Pro Gly Lys Gly Ile 
                1125                1130                1135


Gln Leu Lys Ala Arg Ala Phe Glu Leu Ser Glu Gly Asp Val Leu Lys 
            1140                1145                1150


Val Tyr Asp Gly Asn Asn Asn Ser Ala Arg Leu Leu Gly Val Phe Ser 
        1155                1160                1165


His Ser Glu Met Met Gly Val Thr Leu Asn Ser Thr Ser Ser Ser Leu 
    1170                1175                1180


Trp Leu Asp Phe Ile Thr Asp Ala Glu Asn Thr Ser Lys Gly Phe Glu 
1185                1190                1195                1200


Leu His Phe Ser Ser Phe Glu Leu Ile Lys Cys Glu Asp Pro Gly Thr 
                1205                1210                1215


Pro Lys Phe Gly Tyr Lys Val His Asp Glu Gly His Phe Ala Gly Ser 
            1220                1225                1230


Ser Val Ser Phe Ser Cys Asp Pro Gly Tyr Ser Leu Arg Gly Ser Glu 
        1235                1240                1245


Glu Leu Leu Cys Leu Ser Gly Glu Arg Arg Thr Trp Asp Arg Pro Leu 
    1250                1255                1260


Pro Thr Cys Val Ala Glu Cys Gly Gly Thr Val Arg Gly Glu Val Ser 
1265                1270                1275                1280


Gly Gln Val Leu Ser Pro Gly Tyr Pro Ala Pro Tyr Glu His Asn Leu 
                1285                1290                1295


Asn Cys Ile Trp Thr Ile Glu Ala Glu Ala Gly Cys Thr Ile Gly Leu 
            1300                1305                1310


His Phe Leu Val Phe Asp Thr Glu Glu Val His Asp Val Leu Arg Ile 
        1315                1320                1325


Trp Asp Gly Pro Val Glu Ser Gly Val Leu Leu Lys Glu Leu Ser Gly 
    1330                1335                1340


Pro Ala Leu Pro Lys Asp Leu His Ser Thr Phe Asn Ser Val Val Leu 
1345                1350                1355                1360


Gln Phe Ser Thr Asp Phe Phe Thr Ser Lys Gln Gly Phe Ala Ile Gln 
                1365                1370                1375


Phe Ser Val Ser Thr Ala Thr Ser Cys Asn Asp Pro Gly Ile Pro Gln 
            1380                1385                1390


Asn Gly Ser Arg Ser Gly Asp Ser Trp Glu Ala Gly Asp Ser Thr Val 
        1395                1400                1405


Phe Gln Cys Asp Pro Gly Tyr Ala Leu Gln Gly Ser Ala Glu Ile Ser 
    1410                1415                1420


Cys Val Lys Ile Glu Asn Arg Phe Phe Trp Gln Pro Ser Pro Pro Thr 
1425                1430                1435                1440


Cys Ile Ala Pro Cys Gly Gly Asp Leu Thr Gly Pro Ser Gly Val Ile 
                1445                1450                1455


Leu Ser Pro Asn Tyr Pro Glu Pro Tyr Pro Pro Gly Lys Glu Cys Asp 
            1460                1465                1470


Trp Lys Val Thr Val Ser Pro Asp Tyr Val Ile Ala Leu Val Phe Asn 
        1475                1480                1485


Ile Phe Asn Leu Glu Pro Gly Tyr Asp Phe Leu His Ile Tyr Asp Gly 
    1490                1495                1500


Arg Asp Ser Leu Ser Pro Leu Ile Gly Ser Phe Tyr Gly Ser Gln Leu 
1505                1510                1515                1520


Pro Gly Arg Ile Glu Ser Ser Ser Asn Ser Leu Phe Leu Ala Phe Arg 
                1525                1530                1535


Ser Asp Ala Ser Val Ser Asn Ala Gly Phe Val Ile Asp Tyr Thr Glu 
            1540                1545                1550


Asn Pro Arg Glu Ser Cys Phe Asp Pro Gly Ser Ile Lys Asn Gly Thr 
        1555                1560                1565


Arg Val Gly Ser Asp Leu Lys Leu Gly Ser Ser Val Thr Tyr Tyr Cys 
    1570                1575                1580


His Gly Gly Tyr Glu Val Glu Gly Thr Ser Thr Leu Ser Cys Ile Leu 
1585                1590                1595                1600


Gly Pro Asp Gly Lys Pro Val Trp Asn Asn Pro Arg Pro Val Cys Thr 
                1605                1610                1615


Ala Pro Cys Gly Gly Gln Tyr Val Gly Ser Asp Gly Val Val Leu Ser 
            1620                1625                1630


Pro Asn Tyr Pro Gln Asn Tyr Thr Ser Gly Gln Ile Cys Leu Tyr Phe 
        1635                1640                1645


Val Thr Val Pro Lys Asp Tyr Val Val Phe Gly Gln Phe Ala Phe Phe 
    1650                1655                1660


His Thr Ala Leu Asn Asp Val Val Glu Val His Asp Gly His Ser Gln 
1665                1670                1675                1680


His Ser Arg Leu Leu Ser Ser Leu Ser Gly Ser His Thr Gly Glu Ser 
                1685                1690                1695


Leu Pro Leu Ala Thr Ser Asn Gln Val Leu Ile Lys Phe Ser Ala Lys 
            1700                1705                1710


Gly Leu Ala Pro Ala Arg Gly Phe His Phe Val Tyr Gln Ala Val Pro 
        1715                1720                1725


Arg Thr Ser Ala Thr Gln Cys Ser Ser Val Pro Glu Pro Arg Tyr Gly 
    1730                1735                1740


Lys Arg Leu Gly Ser Asp Phe Ser Val Gly Ala Ile Val Arg Phe Glu 
1745                1750                1755                1760


Cys Asn Ser Gly Tyr Ala Leu Gln Gly Ser Pro Glu Ile Glu Cys Leu 
                1765                1770                1775


Pro Val Pro Gly Ala Leu Ala Gln Trp Asn Val Ser Ala Pro Thr Cys 
            1780                1785                1790


Val Val Pro Cys Gly Gly Asn Leu Thr Glu Arg Arg Gly Thr Ile Leu 
        1795                1800                1805


Ser Pro Gly Phe Pro Glu Pro Tyr Leu Asn Ser Leu Asn Cys Val Trp 
    1810                1815                1820


Lys Ile Val Val Pro Glu Gly Ala Gly Ile Gln Ile Gln Val Val Ser 
1825                1830                1835                1840


Phe Val Thr Glu Gln Asn Trp Asp Ser Leu Glu Val Phe Asp Gly Ala 
                1845                1850                1855


Asp Asn Thr Val Thr Met Leu Gly Ser Phe Ser Gly Thr Thr Val Pro 
            1860                1865                1870


Ala Leu Leu Asn Ser Thr Ser Asn Gln Leu Tyr Leu His Phe Tyr Ser 
        1875                1880                1885


Asp Ile Ser Val Ser Ala Ala Gly Phe His Leu Glu Tyr Lys Thr Val 
    1890                1895                1900


Gly Leu Ser Ser Cys Pro Glu Pro Ala Val Pro Ser Asn Gly Val Lys 
1905                1910                1915                1920


Thr Gly Glu Arg Tyr Leu Val Asn Asp Val Val Ser Phe Gln Cys Glu 
                1925                1930                1935


Pro Gly Tyr Ala Leu Gln Gly His Ala His Ile Ser Cys Met Pro Gly 
            1940                1945                1950


Thr Val Arg Arg Trp Asn Tyr Pro Pro Pro Leu Cys Ile Ala Gln Cys 
        1955                1960                1965


Gly Gly Thr Val Glu Glu Met Glu Gly Val Ile Leu Ser Pro Gly Phe 
    1970                1975                1980


Pro Gly Asn Tyr Pro Ser Asn Met Asp Cys Ser Trp Lys Ile Ala Leu 
1985                1990                1995                2000


Pro Val Gly Phe Gly Ala His Ile Gln Phe Leu Asn Phe Ser Thr Glu 
                2005                2010                2015


Pro Asn His Asp Tyr Ile Glu Ile Arg Asn Gly Pro Tyr Glu Thr Ser 
            2020                2025                2030


Arg Met Met Gly Arg Phe Ser Gly Ser Glu Leu Pro Ser Ser Leu Leu 
        2035                2040                2045


Ser Thr Ser His Glu Thr Thr Val Tyr Phe His Ser Asp His Ser Gln 
    2050                2055                2060


Asn Arg Pro Gly Phe Lys Leu Glu Tyr Gln Asp Leu Thr Tyr Ser His 
2065                2070                2075                2080


Gln Ile Ser Ser Phe Leu Arg Gly Phe Asp Leu Ser Glu Leu Glu Arg 
                2085                2090                2095


Thr Asn Ser Thr Pro Pro Val Ala Ala Ser Tyr Val Trp Asp Leu Asp 
            2100                2105                2110


Pro Gly Cys Glu Ala Tyr Glu Leu Gln Glu Cys Pro Asp Pro Glu Pro 
        2115                2120                2125


Phe Ala Asn Gly Ile Val Arg Gly Ala Gly Tyr Asn Val Gly Gln Ser 
    2130                2135                2140


Val Thr Phe Glu Cys Leu Pro Gly Tyr Gln Leu Thr Gly His Pro Val 
2145                2150                2155                2160


Leu Thr Cys Gln His Gly Thr Asn Arg Asn Trp Asp His Pro Leu Pro 
                2165                2170                2175


Lys Cys Glu Val Pro Cys Gly Gly Asn Ile Thr Ser Ser Asn Gly Thr 
            2180                2185                2190


Val Tyr Ser Pro Gly Phe Pro Ser Pro Tyr Ser Ser Ser Gln Asp Cys 
        2195                2200                2205


Val Trp Leu Ile Thr Val Pro Ile Gly His Gly Val Arg Leu Asn Leu 
    2210                2215                2220


Ser Leu Leu Gln Thr Glu Pro Ser Gly Asp Phe Ile Thr Ile Trp Asp 
2225                2230                2235                2240


Gly Pro Gln Gln Thr Ala Pro Arg Leu Gly Val Phe Thr Arg Ser Met 
                2245                2250                2255


Ala Lys Lys Thr Val Gln Ser Ser Ser Asn Gln Val Leu Leu Lys Phe 
            2260                2265                2270


His Arg Asp Ala Ala Thr Gly Gly Ile Phe Ala Ile Ala Phe Ser Ala 
        2275                2280                2285


Tyr Pro Leu Thr Lys Cys Pro Pro Pro Thr Ile Leu Pro Asn Ala Glu 
    2290                2295                2300


Val Val Thr Glu Asn Glu Glu Phe Asn Ile Gly Asp Ile Val Arg Tyr 
2305                2310                2315                2320


Arg Cys Leu Pro Gly Phe Thr Leu Val Gly Asn Glu Ile Leu Thr Cys 
                2325                2330                2335


Lys Leu Gly Thr Tyr Leu Gln Phe Glu Gly Pro Pro Pro Ile Cys Glu 
            2340                2345                2350


Val His Cys Pro Thr Asn Glu Leu Leu Thr Asp Ser Thr Gly Val Ile 
        2355                2360                2365


Leu Ser Gln Ser Tyr Pro Gly Ser Tyr Pro Gln Phe Gln Thr Cys Ser 
    2370                2375                2380


Trp Leu Val Arg Val Glu Pro Asp Tyr Asn Ile Ser Leu Thr Val Glu 
2385                2390                2395                2400


Tyr Phe Leu Ser Glu Lys Gln Tyr Asp Glu Phe Glu Ile Phe Asp Gly 
                2405                2410                2415


Pro Ser Gly Gln Ser Pro Leu Leu Lys Ala Leu Ser Gly Asn Tyr Ser 
            2420                2425                2430


Ala Pro Leu Ile Val Thr Ser Ser Ser Asn Ser Val Tyr Leu Arg Trp 
        2435                2440                2445


Ser Ser Asp His Ala Tyr Asn Arg Lys Gly Phe Lys Ile Arg Tyr Ser 
    2450                2455                2460


Ala Pro Tyr Cys Ser Leu Pro Arg Ala Pro Leu His Gly Phe Ile Leu 
2465                2470                2475                2480


Gly Gln Thr Ser Thr Gln Pro Gly Gly Ser Ile His Phe Gly Cys Asn 
                2485                2490                2495


Ala Gly Tyr Arg Leu Val Gly His Ser Met Ala Ile Cys Thr Arg His 
            2500                2505                2510


Pro Gln Gly Tyr His Leu Trp Ser Glu Ala Ile Pro Leu Cys Gln Ala 
        2515                2520                2525


Leu Ser Cys Gly Leu Pro Glu Ala Pro Lys Asn Gly Met Val Phe Gly 
    2530                2535                2540


Lys Glu Tyr Thr Val Gly Thr Lys Ala Met Tyr Ser Cys Ser Glu Gly 
2545                2550                2555                2560


Tyr His Leu Gln Ala Gly Ala Glu Ala Thr Ala Glu Cys Leu Asp Thr 
                2565                2570                2575


Gly Leu Trp Ser Asn Arg Asn Val Pro Pro Gln Cys Val Pro Val Thr 
            2580                2585                2590


Cys Pro Asp Val Ser Ser Ile Ser Val Glu His Gly Arg Trp Arg Leu 
        2595                2600                2605


Ile Phe Glu Thr Gln Tyr Gln Phe Gln Ala Gln Leu Met Leu Ile Cys 
    2610                2615                2620


Asp Pro Gly Tyr Tyr Tyr Thr Gly Gln Arg Val Ile Arg Cys Gln Ala 
2625                2630                2635                2640


Asn Gly Lys Trp Ser Leu Gly Asp Ser Thr Pro Thr Cys Arg Ile Ile 
                2645                2650                2655


Ser Cys Gly Glu Leu Pro Ile Pro Pro Asn Gly His Arg Ile Gly Thr 
            2660                2665                2670


Leu Ser Val Tyr Gly Ala Thr Ala Ile Phe Ser Cys Asn Ser Gly Tyr 
        2675                2680                2685


Thr Leu Val Gly Ser Arg Val Arg Glu Cys Met Ala Asn Gly Leu Trp 
    2690                2695                2700


Ser Gly Ser Glu Val Arg Cys Leu Ala Gly His Cys Gly Thr Pro Glu 
2705                2710                2715                2720


Pro Ile Val Asn Gly His Ile Asn Gly Glu Asn Tyr Ser Tyr Arg Gly 
                2725                2730                2735


Ser Val Val Tyr Gln Cys Asn Ala Gly Phe Arg Leu Ile Gly Met Ser 
            2740                2745                2750


Val Arg Ile Cys Gln Gln Asp His His Trp Ser Gly Lys Thr Pro Phe 
        2755                2760                2765


Cys Val Leu Val Ser Cys Gly His Pro Gly Ser Pro Pro His Ser Gln 
    2770                2775                2780


Met Ser Gly Asp Ser Tyr Thr Val Gly Ala Val Val Arg Tyr Ser Cys 
2785                2790                2795                2800


Ile Gly Lys Arg Thr Leu Val Gly Asn Ser Thr Arg Met Cys Gly Leu 
                2805                2810                2815


Asp Gly His Trp Thr Gly Ser Leu Pro His Cys Ser Gly Thr Ser Val 
            2820                2825                2830


Gly Val Cys Gly Asp Pro Gly Ile Pro Ala His Gly Ile Arg Leu Gly 
        2835                2840                2845


Asp Ser Phe Asp Pro Gly Thr Val Met Arg Phe Ser Cys Glu Ala Gly 
    2850                2855                2860


His Val Leu Arg Gly Ser Ser Glu Arg Thr Cys Gln Ala Asn Gly Ser 
2865                2870                2875                2880


Trp Ser Gly Ser Gln Pro Glu Cys Gly Val Ile Ser Cys Gly Asn Pro 
                2885                2890                2895


Gly Thr Pro Ser Asn Ala Arg Val Val Phe Ser Asp Gly Leu Val Phe 
            2900                2905                2910


Ser Ser Ser Ile Val Tyr Glu Cys Arg Glu Gly Tyr Tyr Ala Thr Gly 
        2915                2920                2925


Leu Leu Ser Arg His Cys Ser Val Asn Gly Thr Trp Thr Gly Ser Asp 
    2930                2935                2940


Pro Glu Cys Leu Val Ile Asn Cys Gly Asp Pro Gly Ile Pro Ala Asn 
2945                2950                2955                2960


Gly Leu Arg Leu Gly Asn Asp Phe Arg Tyr Asn Lys Thr Val Thr Tyr 
                2965                2970                2975


Gln Cys Val Pro Gly Tyr Met Met Glu Ser His Arg Val Ser Val Leu 
            2980                2985                2990


Ser Cys Thr Lys Asp Arg Thr Trp Asn Gly Thr Lys Pro Val Cys Lys 
        2995                3000                3005


Ala Leu Met Cys Lys Pro Pro Pro Leu Ile Pro Asn Gly Lys Val Val 
    3010                3015                3020


Gly Ser Asp Phe Met Trp Gly Ser Ser Val Thr Tyr Ala Cys Leu Glu 
3025                3030                3035                3040


Gly Tyr Gln Leu Ser Leu Pro Ala Val Phe Thr Cys Glu Gly Asn Gly 
                3045                3050                3055


Ser Trp Thr Gly Glu Leu Pro Gln Cys Phe Pro Val Phe Cys Gly Asp 
            3060                3065                3070


Pro Gly Val Pro Ser Arg Gly Arg Arg Glu Asp Arg Gly Phe Ser Tyr 
        3075                3080                3085


Arg Ser Ser Val Ser Phe Ser Cys His Pro Pro Leu Val Leu Val Gly 
    3090                3095                3100


Ser Pro Arg Arg Phe Cys Gln Ser Asp Gly Thr Trp Ser Gly Thr Gln 
3105                3110                3115                3120


Pro Ser Cys Ile Asp Pro Thr Leu Thr Thr Cys Ala Asp Pro Gly Val 
                3125                3130                3135


Pro Gln Phe Gly Ile Gln Asn Asn Ser Gln Gly Tyr Gln Val Gly Ser 
            3140                3145                3150


Thr Val Leu Phe Arg Cys Gln Lys Gly Tyr Leu Leu Gln Gly Ser Thr 
        3155                3160                3165


Thr Arg Thr Cys Leu Pro Asn Leu Thr Trp Ser Gly Thr Pro Pro Asp 
    3170                3175                3180


Cys Val Pro His His Cys Arg Gln Pro Glu Thr Pro Thr His Ala Asn 
3185                3190                3195                3200


Val Gly Ala Leu Asp Leu Pro Ser Met Gly Tyr Thr Leu Ile Tyr Ser 
                3205                3210                3215


Cys Gln Glu Gly Phe Ser Leu Lys Gly Gly Ser Glu His Arg Thr Cys 
            3220                3225                3230


Lys Ala Asp Gly Ser Trp Thr Gly Lys Pro Pro Ile Cys Leu Glu Val 
        3235                3240                3245


Arg Pro Ser Gly Arg Pro Ile Asn Thr Ala Arg Glu Pro Pro Leu Thr 
    3250                3255                3260


Gln Ala Leu Ile Pro Gly Asp Val Phe Ala Lys Asn Ser Leu Trp Lys 
3265                3270                3275                3280


Gly Ala Tyr Glu Tyr Gln Gly Lys Lys Gln Pro Ala Met Leu Arg Val 
                3285                3290                3295


Thr Gly Phe Gln Val Ala Asn Ser Lys Val Asn Ala Thr Met Ile Asp 
            3300                3305                3310


His Ser Gly Val Glu Leu His Leu Ala Gly Thr Tyr Lys Lys Glu Asp 
        3315                3320                3325


Phe His Leu Leu Leu Gln Val Tyr Gln Ile Thr Gly Pro Val Glu Ile 
    3330                3335                3340


Phe Met Asn Lys Phe Lys Asp Asp His Trp Ala Leu Asp Gly His Val 
3345                3350                3355                3360


Ser Ser Glu Ser Ser Gly Ala Thr Phe Ile Tyr Gln Gly Ser Val Lys 
                3365                3370                3375


Gly Gln Gly Phe Gly Gln Phe Gly Phe Gln Arg Leu Asp Leu Arg Leu 
            3380                3385                3390


Leu Glu Ser Asp Pro Glu Ser Ile Gly Arg His Phe Ala Ser Asn Ser 
        3395                3400                3405


Ser Ser Val Ala Ala Ala Ile Leu Val Pro Phe Ile Ala Leu Ile Ile 
    3410                3415                3420


Ala Gly Phe Val Leu Tyr Leu Tyr Lys His Arg Arg Arg Pro Lys Val 
3425                3430                3435                3440


Pro Phe Asn Gly Tyr Ala Gly His Glu Asn Thr Asn Val Arg Ala Thr 
                3445                3450                3455


Phe Glu Asn Pro Met Tyr Asp Arg Asn Ile Gln Pro Thr Asp Ile Met 
            3460                3465                3470


Ala Ser Glu Ala Glu Phe Thr Val Ser Thr Val Cys Thr Ala Val 
        3475                3480                3485


<210>  1796
<211>  4379
<212>  DNA
<213>  Homo sapiens

<400>  1796
gagagacaga caaacagcac aagagacaga aacaaagcag gcagcaccat aggtagggaa     60

gtattttttt tttaagtttg agaggcattt ctgtagacag tccaacaact ggacagacac    120

gcaggcacct tggcaggtag acaggcaaac gacttgtcat ctttgtcagg ttcttcagag    180

ctgtgagttg ctttctggat gcagctgatg ggggttaatc tatggttatt gtgattctct    240

ttccagctga gtgtgggaat tcagtcacag gcactcaggg tactttgctg tcccccaact    300

ttcctgtgaa ctacaataac aatcatgaat gcatctactc catccagacc cagccaggga    360

agggaattca gctgaaagcc agggcattcg aactctccga aggagatgtc ctcaaggttt    420

atgatggcaa caacaactcc gcccgtttgc tgggagtttt tagccattct gagatgatgg    480

gggtgacttt gaacagcaca tccagcagtc tgtggcttga tttcatcact gatgctgaaa    540

acaccagcaa gggctttgaa ctgcactttt ccagctttga actcatcaaa tgtgaggacc    600

caggaacccc caagtttggc tacaaggttc atgatgaagg tcattttgca gggagctccg    660

tgtccttcag ctgtgaccct ggatacagcc tgcggggtag tgaggagctg ctgtgtctga    720

gtggagagcg ccggacctgg gaccggcctc tgcccacctg tgtcgccgag tgtggaggga    780

cagtgagagg agaggtgtcg gggcaggtgc tgtcacccgg gtatccagct ccctatgaac    840

acaatctcaa ctgcatctgg accatcgaag cagaggccgg ctgcaccatt gggctacact    900

tcctggtgtt tgacacagag gaggttcacg acgtgctgcg catctgggat gggcctgtgg    960

agagcggggt tctgctgaag gagctgagtg gcccggccct gcccaaggac ctgcatagca   1020

ccttcaactc ggtcgtcctg cagttcagca ctgacttctt caccagcaag cagggctttg   1080

ccattcaatt ttcagtgtcc acagcaacgt cctgcaatga ccctgggatc ccgcagaatg   1140

ggagtcggag tggtgacagt tgggaagccg gcgactccac agtgttccag tgtgaccctg   1200

gctacgcgct gcagggaagt gcagagatca gctgtgtgaa gatcgagaac aggttcttct   1260

ggcagcccag cccgccaaca tgcatcgctc cctgcggggg agacctgaca ggaccatctg   1320

gagtcatcct ctcaccaaat tacccagaac cctacccgcc aggcaaggag tgtgactgga   1380

aagtgaccgt ctcaccagac tacgtcatcg ccctggtatt taacatcttt aacctggagc   1440

ctggctatga cttcctccat atctacgacg gacgggactc tctcagccct ctcataggaa   1500

gcttctatgg ctcccagctc ccaggccgca ttgaaagcag cagcaacagc ctcttcctcg   1560

ccttccgcag cgatgcatct gtgagcaatg ctggcttcgt cattgactat acagaaaacc   1620

cgcgggagtc atgttttgat cctggttcca tcaagaacgg cacacgggtg gggtccgacc   1680

tgaagctggg ctcctccgtc acctactact gccacggggg ctacgaagtt gagggcacct   1740

cgaccctgag ctgcatcctg gggcctgatg ggaagcccgt gtggaacaat ccccggccag   1800

tctgcacagc cccctgtggg ggacagtatg tgggttcgga cggagtggtc ttgtccccca   1860

actaccccca gaactacacc agtggacaga tctgcttgta ttttgttact gtgcccaagg   1920

actatgtggt gtttggccag ttcgccttct ttcacacggc cctcaacgac gtggtggagg   1980

ttcacgacgg ccacagccag cactcgcggc tcctcagctc cctctcgggc tcccatacag   2040

gagaatcact gcccttggcc acctccaatc aagttctcat taagttcagc gccaaaggcc   2100

tcgcaccagc cagaggcttc cactttgtct accaagcggt tcctcgaacc agcgccacgc   2160

agtgcagctc tgtgccggaa ccccgctatg gcaagaggct gggcagtgac ttctcggtgg   2220

gggccatcgt ccgcttcgaa tgcaactccg gctatgccct gcaggggtcg ccagagatcg   2280

agtgcctccc tgtgcctggg gccttggccc aatggaatgt ctcagcgccc acgtgtgtgg   2340

tgccgtgtgg aggcaacctc acagagcgca ggggcaccat cctgtcccct ggcttcccag   2400

agccgtacct caacagcctc aactgtgtgt ggaagatcgt ggtccccgaa ggcgctggca   2460

tccagatcca agttgtcagt tttgtgacag agcagaactg ggactcgctg gaagtatttg   2520

atggtgcaga taacactgta accatgctgg ggagtttctc aggaacaacc gtgcctgccc   2580

ttctgaacag cacctccaac cagctctacc ttcatttcta ctcagatatc agcgtatctg   2640

cagctggctt ccacttggag tacaaaacgg tgggcctgag cagttgtccg gaacctgctg   2700

tgcccagtaa cggggtgaag actggcgagc gctacttggt gaatgatgtg gtgtctttcc   2760

agtgtgagcc gggatatgcc ctccagggcc acgcccacat ctcctgcatg cccggaacag   2820

tgcggcgatg gaactaccct cctccactct gtattgcaca gtgtggggga acagtggagg   2880

agatggaggg ggtgatcctg agccccggct tcccaggcaa ctaccccagt aacatggact   2940

gctcctggaa aatagcactg cccgtgggct ttggagctca catccagttc ctgaacttct   3000

ccaccgagcc caaccacgac tacatagaaa tccggaatgg cccctatgag accagccgca   3060

tgatgggaag attcagtgga agcgagcttc caagctccct cctctccacg tcccacgaga   3120

ccaccgtgta tttccacagc gaccactccc agaatcggcc aggattcaag ctggagtatc   3180

aggcctatga acttcaagag tgcccagacc cagagccctt tgccaatggc attgtgaggg   3240

gagctggcta caacgtggga caatcagtga ccttcgagtg cctcccgggg tatcaattga   3300

ctggccaccc tgtcctcacg tgtcaacatg gcaccaaccg gaactgggac caccccctgc   3360

ccaagtgtga agtcccttgt ggcgggaaca tcacttcttc caacggcact gtgtactccc   3420

cggggttccc tagcccgtac tccagctccc aggactgtgt ctggctgatc accgtgccca   3480

ttggccatgg cgtccgcctc aacctcagcc tgctgcagac agagccctct ggagatttca   3540

tcaccatctg ggatgggcca cagcaaacag caccacggct cggcgtcttc acccggagca   3600

tggccaagaa aacagtgcag agttcatcca accaggtcct gctcaagttc caccgtgatg   3660

cagccacagg ggggatcttc gccatagctt tctccgggca cttggcagct gtttgtacat   3720

tgtgacaccc ctccacgcac acatctgccc cccagccaca gaagcttgga ccagaggtgg   3780

acacctgagc tgactgcagc aggggcaatc agatgttctc tcttgggaag ttgaaatagg   3840

acccaagaga ttctactttt gcctggaccc atctcctgaa aagataaaaa tccaagtgca   3900

atggattgct gctcttctac tttccatgtg gaccaaaaag tagaacaatc ctatgtgcag   3960

aaagagaatg attgagaagt ggaaaaattt ccttggtttc tgatggccct tcagttcctc   4020

gtcctctacc tttgtgaagt ctggctgcaa acccaccctt gggttctctc ttctctgaga   4080

ggcttttttg cttattctag cctgaattga tttatttaca tccaaaggtt cccaaggaat   4140

acaacaacct aggacccagc aatcctactt ctgggaatta tgcaaagata tgtgcatgaa   4200

gatattgctt gatatgttat aacagggaaa ttagaaataa tctaaatgta aaaatagtaa   4260

gagattaggt attataaatt taaagtgtat actcagagag agagagatag ggaaagatac   4320

agtcattaca aatcattcat gtatgaacct gggcaacata gtgagactct gcctctacc    4379


<210>  1797
<211>  1167
<212>  PRT
<213>  Homo sapiens

<400>  1797

Met Val Ile Val Ile Leu Phe Pro Ala Glu Cys Gly Asn Ser Val Thr 
1               5                   10                  15


Gly Thr Gln Gly Thr Leu Leu Ser Pro Asn Phe Pro Val Asn Tyr Asn 
            20                  25                  30


Asn Asn His Glu Cys Ile Tyr Ser Ile Gln Thr Gln Pro Gly Lys Gly 
        35                  40                  45


Ile Gln Leu Lys Ala Arg Ala Phe Glu Leu Ser Glu Gly Asp Val Leu 
    50                  55                  60


Lys Val Tyr Asp Gly Asn Asn Asn Ser Ala Arg Leu Leu Gly Val Phe 
65                  70                  75                  80


Ser His Ser Glu Met Met Gly Val Thr Leu Asn Ser Thr Ser Ser Ser 
                85                  90                  95


Leu Trp Leu Asp Phe Ile Thr Asp Ala Glu Asn Thr Ser Lys Gly Phe 
            100                 105                 110


Glu Leu His Phe Ser Ser Phe Glu Leu Ile Lys Cys Glu Asp Pro Gly 
        115                 120                 125


Thr Pro Lys Phe Gly Tyr Lys Val His Asp Glu Gly His Phe Ala Gly 
    130                 135                 140


Ser Ser Val Ser Phe Ser Cys Asp Pro Gly Tyr Ser Leu Arg Gly Ser 
145                 150                 155                 160


Glu Glu Leu Leu Cys Leu Ser Gly Glu Arg Arg Thr Trp Asp Arg Pro 
                165                 170                 175


Leu Pro Thr Cys Val Ala Glu Cys Gly Gly Thr Val Arg Gly Glu Val 
            180                 185                 190


Ser Gly Gln Val Leu Ser Pro Gly Tyr Pro Ala Pro Tyr Glu His Asn 
        195                 200                 205


Leu Asn Cys Ile Trp Thr Ile Glu Ala Glu Ala Gly Cys Thr Ile Gly 
    210                 215                 220


Leu His Phe Leu Val Phe Asp Thr Glu Glu Val His Asp Val Leu Arg 
225                 230                 235                 240


Ile Trp Asp Gly Pro Val Glu Ser Gly Val Leu Leu Lys Glu Leu Ser 
                245                 250                 255


Gly Pro Ala Leu Pro Lys Asp Leu His Ser Thr Phe Asn Ser Val Val 
            260                 265                 270


Leu Gln Phe Ser Thr Asp Phe Phe Thr Ser Lys Gln Gly Phe Ala Ile 
        275                 280                 285


Gln Phe Ser Val Ser Thr Ala Thr Ser Cys Asn Asp Pro Gly Ile Pro 
    290                 295                 300


Gln Asn Gly Ser Arg Ser Gly Asp Ser Trp Glu Ala Gly Asp Ser Thr 
305                 310                 315                 320


Val Phe Gln Cys Asp Pro Gly Tyr Ala Leu Gln Gly Ser Ala Glu Ile 
                325                 330                 335


Ser Cys Val Lys Ile Glu Asn Arg Phe Phe Trp Gln Pro Ser Pro Pro 
            340                 345                 350


Thr Cys Ile Ala Pro Cys Gly Gly Asp Leu Thr Gly Pro Ser Gly Val 
        355                 360                 365


Ile Leu Ser Pro Asn Tyr Pro Glu Pro Tyr Pro Pro Gly Lys Glu Cys 
    370                 375                 380


Asp Trp Lys Val Thr Val Ser Pro Asp Tyr Val Ile Ala Leu Val Phe 
385                 390                 395                 400


Asn Ile Phe Asn Leu Glu Pro Gly Tyr Asp Phe Leu His Ile Tyr Asp 
                405                 410                 415


Gly Arg Asp Ser Leu Ser Pro Leu Ile Gly Ser Phe Tyr Gly Ser Gln 
            420                 425                 430


Leu Pro Gly Arg Ile Glu Ser Ser Ser Asn Ser Leu Phe Leu Ala Phe 
        435                 440                 445


Arg Ser Asp Ala Ser Val Ser Asn Ala Gly Phe Val Ile Asp Tyr Thr 
    450                 455                 460


Glu Asn Pro Arg Glu Ser Cys Phe Asp Pro Gly Ser Ile Lys Asn Gly 
465                 470                 475                 480


Thr Arg Val Gly Ser Asp Leu Lys Leu Gly Ser Ser Val Thr Tyr Tyr 
                485                 490                 495


Cys His Gly Gly Tyr Glu Val Glu Gly Thr Ser Thr Leu Ser Cys Ile 
            500                 505                 510


Leu Gly Pro Asp Gly Lys Pro Val Trp Asn Asn Pro Arg Pro Val Cys 
        515                 520                 525


Thr Ala Pro Cys Gly Gly Gln Tyr Val Gly Ser Asp Gly Val Val Leu 
    530                 535                 540


Ser Pro Asn Tyr Pro Gln Asn Tyr Thr Ser Gly Gln Ile Cys Leu Tyr 
545                 550                 555                 560


Phe Val Thr Val Pro Lys Asp Tyr Val Val Phe Gly Gln Phe Ala Phe 
                565                 570                 575


Phe His Thr Ala Leu Asn Asp Val Val Glu Val His Asp Gly His Ser 
            580                 585                 590


Gln His Ser Arg Leu Leu Ser Ser Leu Ser Gly Ser His Thr Gly Glu 
        595                 600                 605


Ser Leu Pro Leu Ala Thr Ser Asn Gln Val Leu Ile Lys Phe Ser Ala 
    610                 615                 620


Lys Gly Leu Ala Pro Ala Arg Gly Phe His Phe Val Tyr Gln Ala Val 
625                 630                 635                 640


Pro Arg Thr Ser Ala Thr Gln Cys Ser Ser Val Pro Glu Pro Arg Tyr 
                645                 650                 655


Gly Lys Arg Leu Gly Ser Asp Phe Ser Val Gly Ala Ile Val Arg Phe 
            660                 665                 670


Glu Cys Asn Ser Gly Tyr Ala Leu Gln Gly Ser Pro Glu Ile Glu Cys 
        675                 680                 685


Leu Pro Val Pro Gly Ala Leu Ala Gln Trp Asn Val Ser Ala Pro Thr 
    690                 695                 700


Cys Val Val Pro Cys Gly Gly Asn Leu Thr Glu Arg Arg Gly Thr Ile 
705                 710                 715                 720


Leu Ser Pro Gly Phe Pro Glu Pro Tyr Leu Asn Ser Leu Asn Cys Val 
                725                 730                 735


Trp Lys Ile Val Val Pro Glu Gly Ala Gly Ile Gln Ile Gln Val Val 
            740                 745                 750


Ser Phe Val Thr Glu Gln Asn Trp Asp Ser Leu Glu Val Phe Asp Gly 
        755                 760                 765


Ala Asp Asn Thr Val Thr Met Leu Gly Ser Phe Ser Gly Thr Thr Val 
    770                 775                 780


Pro Ala Leu Leu Asn Ser Thr Ser Asn Gln Leu Tyr Leu His Phe Tyr 
785                 790                 795                 800


Ser Asp Ile Ser Val Ser Ala Ala Gly Phe His Leu Glu Tyr Lys Thr 
                805                 810                 815


Val Gly Leu Ser Ser Cys Pro Glu Pro Ala Val Pro Ser Asn Gly Val 
            820                 825                 830


Lys Thr Gly Glu Arg Tyr Leu Val Asn Asp Val Val Ser Phe Gln Cys 
        835                 840                 845


Glu Pro Gly Tyr Ala Leu Gln Gly His Ala His Ile Ser Cys Met Pro 
    850                 855                 860


Gly Thr Val Arg Arg Trp Asn Tyr Pro Pro Pro Leu Cys Ile Ala Gln 
865                 870                 875                 880


Cys Gly Gly Thr Val Glu Glu Met Glu Gly Val Ile Leu Ser Pro Gly 
                885                 890                 895


Phe Pro Gly Asn Tyr Pro Ser Asn Met Asp Cys Ser Trp Lys Ile Ala 
            900                 905                 910


Leu Pro Val Gly Phe Gly Ala His Ile Gln Phe Leu Asn Phe Ser Thr 
        915                 920                 925


Glu Pro Asn His Asp Tyr Ile Glu Ile Arg Asn Gly Pro Tyr Glu Thr 
    930                 935                 940


Ser Arg Met Met Gly Arg Phe Ser Gly Ser Glu Leu Pro Ser Ser Leu 
945                 950                 955                 960


Leu Ser Thr Ser His Glu Thr Thr Val Tyr Phe His Ser Asp His Ser 
                965                 970                 975


Gln Asn Arg Pro Gly Phe Lys Leu Glu Tyr Gln Ala Tyr Glu Leu Gln 
            980                 985                 990


Glu Cys Pro Asp Pro Glu Pro Phe Ala Asn Gly Ile Val Arg Gly Ala 
        995                 1000                1005


Gly Tyr Asn Val Gly Gln Ser Val Thr Phe Glu Cys Leu Pro Gly Tyr 
    1010                1015                1020


Gln Leu Thr Gly His Pro Val Leu Thr Cys Gln His Gly Thr Asn Arg 
1025                1030                1035                1040


Asn Trp Asp His Pro Leu Pro Lys Cys Glu Val Pro Cys Gly Gly Asn 
                1045                1050                1055


Ile Thr Ser Ser Asn Gly Thr Val Tyr Ser Pro Gly Phe Pro Ser Pro 
            1060                1065                1070


Tyr Ser Ser Ser Gln Asp Cys Val Trp Leu Ile Thr Val Pro Ile Gly 
        1075                1080                1085


His Gly Val Arg Leu Asn Leu Ser Leu Leu Gln Thr Glu Pro Ser Gly 
    1090                1095                1100


Asp Phe Ile Thr Ile Trp Asp Gly Pro Gln Gln Thr Ala Pro Arg Leu 
1105                1110                1115                1120


Gly Val Phe Thr Arg Ser Met Ala Lys Lys Thr Val Gln Ser Ser Ser 
                1125                1130                1135


Asn Gln Val Leu Leu Lys Phe His Arg Asp Ala Ala Thr Gly Gly Ile 
            1140                1145                1150


Phe Ala Ile Ala Phe Ser Gly His Leu Ala Ala Val Cys Thr Leu 
        1155                1160                1165


<210>  1798
<211>  592
<212>  DNA
<213>  Homo sapiens

<400>  1798
ggacaggcag ctagcctccc ctggggcagg cagggaccag aagagcccca gagggtcttg     60

tagaacagag gcggaggagg agaggacaga aaggacaggg agacaaccaa ggaggccctg    120

aagagactga atgggagagt gtgactgctc cctgcaaatc ctccccatgt ctggactgag    180

gaaatagctc gaagcaccat ccgtctcctg gtggagcagc agcagcgtcc agaggctggg    240

ggctgaggct ccttgtttcc aacaagctcc taggtgatgg atgctgctgg caggtgcacc    300

acactgagtt gcaagactcg tccctccagg cacccccttc acaggttcag catcctcgct    360

gccatctcct cacaaatgcg ggaagggagc caccacccca ggctgggcta actcgcatga    420

ggacaccact aacattgtct gcgttccatt tacgttagac aggcaggtct acaatgtttg    480

aagtttacag atttcttgga tatagcagtg aaaggtttgt attttttatc tgtaaggaaa    540

aattgtgaag tttacatcat tgcaaaataa acagaactgt gacttctgtt tc            592


<210>  1799
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  1799

Met Asp Ala Ala Gly Arg Cys Thr Thr Leu Ser Cys Lys Thr Arg Pro 
1               5                   10                  15


Ser Arg His Pro Leu His Arg Phe Ser Ile Leu Ala Ala Ile Ser Ser 
            20                  25                  30


Gln Met Arg Glu Gly Ser His His Pro Arg Leu Gly 
        35                  40


<210>  1800
<211>  638
<212>  DNA
<213>  Homo sapiens

<400>  1800
caggccaagg aatgcctgca gcccgggatt cctcctaagc cgtgttccat ctgtgtggga     60

ccccactgga aatcggactg tgtaactcac ctggcagcca ctcccagatc ccctggaact    120

ctggcccaag gctctctgac tgactccttc ttggcttagc agcggaagac tgatgctgcc    180

cgatggcctt ggaagccccg tagaccatca cggatgctga gcttcgggta actctcactg    240

tggaagggtt tgaatcacct tacaagctct cctgacatcc ttgactttat ctgctgctct    300

gttccacact cacagaagct tcttactgag aggagggcaa ccctagccca agagttccag    360

aaagacaaga aggccaatgg atctggggta cgtgtgctga gaagacacag gacccggctt    420

agggcctgaa tcctgggcag aatgtgcatc acctccaagc tgtgaattcc acacgctata    480

aaagatgctt atgaaccact agttatgact caaaacagga caggtgtatt tgtacataag    540

ttggttttat gtcaagaata ttagggaaag gattatcctt ctggtctttg gggcagaata    600

agctgaaagc aggctgggga atctaattcc cttggctc                            638


<210>  1801
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  1801

Leu Ser Leu Trp Lys Gly Leu Asn His Leu Thr Ser Ser Pro Asp Ile 
1               5                   10                  15


Leu Asp Phe Ile Cys Cys Ser Val Pro His Ser Gln Lys Leu Leu Thr 
            20                  25                  30


Glu Arg Arg Ala Thr Leu Ala Gln Glu Phe Gln Lys Asp Lys Lys Ala 
        35                  40                  45


Asn Gly Ser Gly Val Arg Val Leu Arg Arg His Arg Thr Arg Leu Arg 
    50                  55                  60


Ala 
65


<210>  1802
<211>  790
<212>  DNA
<213>  Homo sapiens

<400>  1802
gcttttgccg cctgtaccct tcctggagca acccgtgctt ttgaaaaatg accatgccga     60

aggggaacta acactcccag cctggtgcgg gtcttgtcaa tctgattttt aaatgatgga    120

ggaggaggtt tgaggacaaa gctcatggtg gcattaccac tatcagggac gctgcaaaga    180

tcaagtgaaa aggggaaaag gctcttctca atgtgagcac attcacaggc tctgagaaca    240

gagaggtatt taaagtgaac tggaacaaac ctgcaacatc cggtgcgttc tgccttcaaa    300

aatagctgcc agttagaaag ggttatttac atattgattt catgctaact ttgtaatgga    360

atgtgctgcc tgcctgcctg cctgagacct aacaactgtc atcataattt tttctaaaaa    420

tacagtcaga gaaaaacact cattgaaccc tccactggaa agtagctgca aaagaccccc    480

tgatcccaaa cctgcttgac agaccacagc caagggcagg gacactcaac aactgtaaac    540

gaggaacatt tcacagcggc agctggcccc tctcttcttc caaccagcca atattttttg    600

tctttctaga aaacctgtct tgttcaaagg cctgatggag ctgattcggt tgtgatcctg    660

ggcatatgga tggcatattt gctgcgagct agccggcccc cgctgctgcg gacaaatctt    720

tcattcatga acaggagctt gttaggccaa ctccggactc taaagccact taattaaatt    780

gtggaaagtc                                                           790


<210>  1803
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  1803

Met Ala Tyr Leu Leu Arg Ala Ser Arg Pro Pro Leu Leu Arg Thr Asn 
1               5                   10                  15


Leu Ser Phe Met Asn Arg Ser Leu Leu Gly Gln Leu Arg Thr Leu Lys 
            20                  25                  30


Pro Leu Asn 
        35


<210>  1804
<211>  5708
<212>  DNA
<213>  Homo sapiens

<400>  1804
ataaggtatg aaagatgtgg cctgcagaga gccggcacta tctctactgc tgctgctgct     60

gctactgctg ctgttgctac cgctgcctct gctgccaccg ccactactgc tgccagcgga    120

gccgctagga gtgagcatcc cctctccggg atacccagct ccgcggcgtc tcccgcgcgc    180

cctggcccca cacggacctg ccagccccag ggaacaaaag cggagcccgc tcgccctcta    240

ctgcagccgg aggatgagtc gagagggctg agcggagagt gtggtcctcg gcggctggag    300

ctatttcctt ggcttctctc catgacgatt cctgactcgt ggccccggca atcttgggaa    360

gacatcatcc agcttcttca gtccagaccc tgggcacccc ccttttgcca ggatcgtccc    420

cacccagcct ggacacattg actgaactgt tttctaggac actgcactca gcaagacatg    480

gtggtgagcc ctgactctca gtcttcatga ttgaagaact cttttgtaca acacaaagca    540

ctcaaaaaga gtgaatgaaa tgtgcagctc agagtgtcat ttctgaaggg aggagtcttt    600

ctcttggaga agagtcctca atgagcctgg ccgaggcccg ggatctgtgt gaagtggact    660

aaggattaag taggatgtca actgagacag aacttcaagt agctgtgaaa accagcgcca    720

agaaagactc cagaaagaaa ggtcaggatc gcagtgaagc cactttgata aagaggttta    780

aaggtgaagg ggtccggtac aaagccaaat tgatcgggat tgatgaagtt tccgcagctc    840

ggggagacaa gttatgtcaa gattccatga tgaaactcaa gggcgttgtt gctggcgctc    900

gttccaaagg agaacacaaa cagaaaatct ttttaaccat ctcctttgga ggaatcaaaa    960

tctttgatga gaagacaggg gcccttcagc atcatcatgc tgttcatgaa atatcctaca   1020

ttgcaaagga cattacagat caccgggcct ttggatatgt ttgtgggaag gaagggaatc   1080

acagatttgt ggccataaaa acagcccagg cggctgaacc tgttattctg gacttgagag   1140

atctctttca actcatttat gaattgaagc aaagagaaga attagaaaaa aaggcacaaa   1200

aggataagca gtgtgaacaa gctgtgtacc agacaatatt ggaagaggat gttgaagatc   1260

ctgtgtacca gtacattgtg tttgaggctg gacacgagcc aatccgtgat cccgaaacgg   1320

aagaaaacat ttatcaggtt cccaccagcc aaaagaagga aggtgtttat gatgtgccaa   1380

aaagtcaacc tgtaagtgct gtgacccaat tagaactttt tggggacatg tccacacccc   1440

ctgatataac ctctcccccc actcctgcaa ctccaggtga tgcctttatc ccatcttcat   1500

ctcagaccct tccagcgagt gcagatgtgt ttagttctgt acctttcggc actgctgctg   1560

taccctcagg ttacgttgca atgggcgctg tcctcccgtc cttctggggt cagcagcccc   1620

tcgtccaaca gcagatggtc atgggtgccc agccaccagt cgctcaggtg atgccggggg   1680

ctcagcccat cgcatggggc cagccgggtc tctttcctgc cactcagcag ccctggccaa   1740

ctgtggccgg gcagtttccg ccagccgcct tcatgcccac acaaactgtt atgcctttgc   1800

cagctgccat gttccaaggt cccctcaccc cccttgccac cgtcccaggc acgagtgact   1860

ccaccaggtc aagtccacag accgacaagc ccaggcagaa aatgggcaaa gaaacgttta   1920

aggatttcca gatggcccag cctccgcccg tgccctcccg caaacccgac cagccctccc   1980

tcacctgtac ctcagaggcc ttctccagtt acttcaacaa agtcggggtg gcacaggata   2040

cagacgactg tgatgacttt gacatctccc agttgaattt gacccctgtg acttctacca   2100

caccatcgac caactcacct ccaaccccag cccctagaca gagctctcca tccaaatcat   2160

ctgcatccca tgccagtgat cctaccacag atgacatctt tgaagagggc tttgaaagtc   2220

ccagcaaaag cgaagagcaa gaagctcctg atggatcaca ggcctcatcc aacagtgatc   2280

catttggtga gcccagtggg gagcccagtg gtgataatat aagtccacag gccggtagct   2340

agatagcgca ggtctgggag ccagagcctc tgtacgcgca gatcaacaga cctaagaaat   2400

agcatcgatg cgagctcgtg gtgggtgctc aagactggca tggacatcag catcacgaca   2460

ggctctcttg tattctttca cctcttccca caagaaattc atgattgccc aatggaactc   2520

gctcagaaga gggaactaag catttttggc aaccaatggc agatatctat ggcagcacac   2580

aaaaaaagta tagaaagatc cacccaacat taaatcagaa atcaagcaaa tgcttaccca   2640

acaaatattt gagccctcat agctgggttt aagatgactc agtgtgcaaa attattaatt   2700

ccctttttat ttctctacct gttgaccact gttgagacac caaatttgga gtgacaggca   2760

tcagaggatt acaacagggt tggaactgac ttctttaagc aaaagcaaag ggtcttctgt   2820

gaccacaata tcgtcatcca tatgcctttt cacataggat gatgtgtttt ttgtcactcc   2880

atggggcctg gtctgccatt ttcccccctt tccttttttt gtcatgtttg aaaattaata   2940

ggtgtacaaa tttttgtatt gcttttgact ttttttagat atgggtgaag aaatctaact   3000

ggggagaaaa aaagcctcag tgaaatgaat taacttgaaa ttacaagaca aataagtggt   3060

tgattattca ttatgatcac gaatgttgcc aaaacagtcc tttagctatt ctgcatcctg   3120

gtgaagaaag acagctttca gtacgaacct tcattctgtg agtaggaaaa gacatcagat   3180

cccattgatg agaaagatga aaaatgcatc tgatttctta agaagctcta aactctaagt   3240

acaataaaat gatatttttt atttttccga tatcttgctg ctgtgttgct atgcagacaa   3300

gtgtcttctc cacgtgccat tttcaaagaa aagtcatttg ccaaataatt ctggtacaat   3360

tctggtaatg tggttttgga tcttaaaaac caactttcta atggaacaat ggtggcataa   3420

atattcagaa taacaaactg attctgtggt ccaaatggtt catctctatc tctttttgta   3480

catcagaaaa ttcaaatggg atttttattt tataacttga aaaaaaaacc ttaccattaa   3540

actctttaaa tatttaaggg aaatggcttt aaggagttct aatgaaaaaa aattgtcttt   3600

tttttgtaaa tataaatgtt aatgaaaatg atttttaata atgccattac actgtagaga   3660

aggtagcaga ttgagtgcaa ggtgtgacaa acttgatgga tggggctcac tttccagacg   3720

ttattctgga gcatatggta ggaagctgga gtgcagggac agctggcagg agcagttggc   3780

caatcagcag ctagtgaacg ggaagggagc acgtgactcc atcatctagc ctttccacga   3840

gagtccccac cctacgtgca acacaagaaa aagacaattc acattctgaa gaattcagat   3900

tctgaaactc tcccacctcc ccactcccac ctacccccga tataaatcac tggactgttt   3960

gtacgtgaaa cagaagaggc taagcttcct ttttttacac ttatgagaca aaaagtgcag   4020

tgtttggttc gtatgtttag cacatgattt tcataaagaa tctatatatt tttgccctac   4080

agagaattgt tatacaggtc aagtgtgttt tcctgatgtt cctatgcagt tacagtatgt   4140

tgaaagtgtt ttaacactaa gaagaaaact ttaaagattc atgtgattaa ttggatttga   4200

ggataattat tattatttgg tttttagatt tgaaaagtag aatttccatt gagacaattg   4260

atttgaatag gcctgcattt gattcttcat atcaatagaa actaaaatga tttgggagat   4320

tcatttgaaa aatgattgta tacttgttca caaagcgaaa agtgatacat gaaggtaatg   4380

gttatcattt aaagcccaca ttttacacta tcaggtcaca ggagtctaat ttttttttca   4440

gttagataaa ctgaccaaac gtctattcaa gaatatatgt caatatcatc ctaatgtgga   4500

aggtccgaag aaccagaaaa gtgagaaggg ccgtttacct ccctctgtag ctatcacctg   4560

ttggtccaca gagtttcttg agaaatgagc aaacatttta tgattaggta accctttcac   4620

atgaacggga agatgggaaa ggtggaatga ccataagagt tggcctgaga ccagtttgtt   4680

ttctggggat ttggtaagat aggcagttcc catgggaaat tgcttaaatt gctttgttgc   4740

ctatgatttg attctaaaca agtggtgcta tcttctccct caatatggct gtcttgagtt   4800

tgtcttgcag tatcacacca ttataccaat tctttgggtt gcttctgaca cattcaaagt   4860

gaactctggc tgatgttgct gtttcaggta taccatctgg agttaatttc ctagcagaag   4920

gtgaaagtcc aggagaattg tcctctttca ttgaacatga ttgaaaatgt aactggctct   4980

gaacttcaag aagatagatg cccaagtgat gcattaaagt aagggaaata aagtcaagtt   5040

tttcaactgc catccatatt ctcattggca gaattctgat ttttttccaa gcactgtttg   5100

gtgagcctgg aagcaccgta tcctgtccca ggagtacagt gaaatttcca agcaagagct   5160

gaggtgccaa taccaaaaga ccatggggag tctgcacggt tctggttaga tcaatagaaa   5220

atccatgtgt acaactgtta attcctcatc ctccactagc actaaatttg tcactttaaa   5280

ttttgaaacc agggaaacac cacctgtcat tctgtcccca ttctccatag ctcttcaatc   5340

tttacatgcc gcaagacttt tttgatagct cgtactcatc ccagtgtctc ctgaaacccc   5400

atcatgtaat gtactgggca ccttctttta aacaaatgtt tactctgtgg gtttggttca   5460

tttcaatttc tgcgttctga cacatatttt tttaataaag atgagaaaga gaaaatgact   5520

gttgcagtac ctttctagac ctactttaac tttacctcag atgacagttt gttaacatat   5580

atggacacat tatttttaac tttatgtaca atgcattcaa cagaacagca aaatttttag   5640

aaattttcca ttaatttctg taacacacca tgtaaaactg ttacaaataa acatgtttga   5700

gaacaaca                                                            5708


<210>  1805
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  1805

Met Ser Thr Glu Thr Glu Leu Gln Val Ala Val Lys Thr Ser Ala Lys 
1               5                   10                  15


Lys Asp Ser Arg Lys Lys Gly Gln Asp Arg Ser Glu Ala Thr Leu Ile 
            20                  25                  30


Lys Arg Phe Lys Gly Glu Gly Val Arg Tyr Lys Ala Lys Leu Ile Gly 
        35                  40                  45


Ile Asp Glu Val Ser Ala Ala Arg Gly Asp Lys Leu Cys Gln Asp Ser 
    50                  55                  60


Met Met Lys Leu Lys Gly Val Val Ala Gly Ala Arg Ser Lys Gly Glu 
65                  70                  75                  80


His Lys Gln Lys Ile Phe Leu Thr Ile Ser Phe Gly Gly Ile Lys Ile 
                85                  90                  95


Phe Asp Glu Lys Thr Gly Ala Leu Gln His His His Ala Val His Glu 
            100                 105                 110


Ile Ser Tyr Ile Ala Lys Asp Ile Thr Asp His Arg Ala Phe Gly Tyr 
        115                 120                 125


Val Cys Gly Lys Glu Gly Asn His Arg Phe Val Ala Ile Lys Thr Ala 
    130                 135                 140


Gln Ala Ala Glu Pro Val Ile Leu Asp Leu Arg Asp Leu Phe Gln Leu 
145                 150                 155                 160


Ile Tyr Glu Leu Lys Gln Arg Glu Glu Leu Glu Lys Lys Ala Gln Lys 
                165                 170                 175


Asp Lys Gln Cys Glu Gln Ala Val Tyr Gln Thr Ile Leu Glu Glu Asp 
            180                 185                 190


Val Glu Asp Pro Val Tyr Gln Tyr Ile Val Phe Glu Ala Gly His Glu 
        195                 200                 205


Pro Ile Arg Asp Pro Glu Thr Glu Glu Asn Ile Tyr Gln Val Pro Thr 
    210                 215                 220


Ser Gln Lys Lys Glu Gly Val Tyr Asp Val Pro Lys Ser Gln Pro Val 
225                 230                 235                 240


Ser Ala Val Thr Gln Leu Glu Leu Phe Gly Asp Met Ser Thr Pro Pro 
                245                 250                 255


Asp Ile Thr Ser Pro Pro Thr Pro Ala Thr Pro Gly Asp Ala Phe Ile 
            260                 265                 270


Pro Ser Ser Ser Gln Thr Leu Pro Ala Ser Ala Asp Val Phe Ser Ser 
        275                 280                 285


Val Pro Phe Gly Thr Ala Ala Val Pro Ser Gly Tyr Val Ala Met Gly 
    290                 295                 300


Ala Val Leu Pro Ser Phe Trp Gly Gln Gln Pro Leu Val Gln Gln Gln 
305                 310                 315                 320


Met Val Met Gly Ala Gln Pro Pro Val Ala Gln Val Met Pro Gly Ala 
                325                 330                 335


Gln Pro Ile Ala Trp Gly Gln Pro Gly Leu Phe Pro Ala Thr Gln Gln 
            340                 345                 350


Pro Trp Pro Thr Val Ala Gly Gln Phe Pro Pro Ala Ala Phe Met Pro 
        355                 360                 365


Thr Gln Thr Val Met Pro Leu Pro Ala Ala Met Phe Gln Gly Pro Leu 
    370                 375                 380


Thr Pro Leu Ala Thr Val Pro Gly Thr Ser Asp Ser Thr Arg Ser Ser 
385                 390                 395                 400


Pro Gln Thr Asp Lys Pro Arg Gln Lys Met Gly Lys Glu Thr Phe Lys 
                405                 410                 415


Asp Phe Gln Met Ala Gln Pro Pro Pro Val Pro Ser Arg Lys Pro Asp 
            420                 425                 430


Gln Pro Ser Leu Thr Cys Thr Ser Glu Ala Phe Ser Ser Tyr Phe Asn 
        435                 440                 445


Lys Val Gly Val Ala Gln Asp Thr Asp Asp Cys Asp Asp Phe Asp Ile 
    450                 455                 460


Ser Gln Leu Asn Leu Thr Pro Val Thr Ser Thr Thr Pro Ser Thr Asn 
465                 470                 475                 480


Ser Pro Pro Thr Pro Ala Pro Arg Gln Ser Ser Pro Ser Lys Ser Ser 
                485                 490                 495


Ala Ser His Ala Ser Asp Pro Thr Thr Asp Asp Ile Phe Glu Glu Gly 
            500                 505                 510


Phe Glu Ser Pro Ser Lys Ser Glu Glu Gln Glu Ala Pro Asp Gly Ser 
        515                 520                 525


Gln Ala Ser Ser Asn Ser Asp Pro Phe Gly Glu Pro Ser Gly Glu Pro 
    530                 535                 540


Ser Gly Asp Asn Ile Ser Pro Gln Ala Gly Ser 
545                 550                 555


<210>  1806
<211>  2580
<212>  DNA
<213>  Homo sapiens

<400>  1806
ataaggtatg aaagatgtgg cctgcagaga gccggcacta tctctactgc tgctgctgct     60

gctactgctg ctgttgctac cgctgcctct gctgccaccg ccactactgc tgccagcgga    120

gccgctagga gtgagcatcc cctctccggg atacccagct ccgcggcgtc tcccgcgcgc    180

cctggcccca cacggacctg ccagccccag ggaacaaaag cggagcccgc tcgccctcta    240

ctgcagccgg aggatgagtc gagagggctg agcggagagt gtggtcctcg gcggctggag    300

ctatttcctt ggcttctctc catgacgatt cctgactcgt ggccccggca atcttgggaa    360

gacatcatcc agcttcttca gtccagaccc tgggcacccc ccttttgcca ggatcgtccc    420

cacccagcct ggacacattg actgaactgt tttctaggac actgcactca gcaagacatg    480

gtggtgagcc ctgactctca gtcttcatga ttgaagaact cttttgtaca acacaaagca    540

ctcaaaaaga gtgaatgaaa tgtgcagctc agagtgtcat ttctgaaggg aggagtcttt    600

ctcttggaga agagtcctca atgagcctgg ccgaggcccg ggatctgtgt gaagtggact    660

aaggattaag taggatgtca actgagacag aacttcaagt agctgtgaaa accagcgcca    720

agaaagactc cagaaagaaa ggtcaggatc gcagtgaagc cactttgata aagaggttta    780

aaggtgaagg ggtccggtac aaagccaaat tgatcgggat tgatgaagtt tccgcagctc    840

ggggagacaa gttatgtcaa gattccatga tgaaactcaa gggcgttgtt gctggcgctc    900

gttccaaagg agaacacaaa cagaaaatct ttttaaccat ctcctttgga ggaatcaaaa    960

tctttgatga gaagacaggg gcccttcagc atcatcatgc tgttcatgaa atatcctaca   1020

ttgcaaagga cattacagat caccgggcct ttggatatgt ttgtgggaag gaagggaatc   1080

acagatttgt ggccataaaa acagcccagg cggctgaacc tgttattctg gacttgagag   1140

atctctttca actcatttat gaattgaagc aaagagaaga attagaaaaa aaggcacaaa   1200

aggataagca gtgtgaacaa gctgtgtacc agacaatatt ggaagaggat gttgaagatc   1260

ctgtgtacca gtacattgtg tttgaggctg gacacgagcc aatccgtgat cccgaaacgg   1320

aagaaaacat ttatcaggtt cccaccagcc aaaagaagga aggtgtttat gatgtgccaa   1380

aaagtcaacc tgtaagtgct gtgacccaat tagaactttt tggggacatg tccacacccc   1440

ctgatataac ctctcccccc actcctgcaa ctccaggtga tgcctttatc ccatcttcat   1500

ctcagaccct tccagcgagt gcagatgtgt ttagttctgt acctttcggc actgctgctg   1560

taccctcagg ttacgttgca atgggcgctg tcctcccgtc cttctggggt cagcagcccc   1620

tcgtccaaca gcagatggtc atgggtgccc agccaccagt cgctcaggtg atgccggggg   1680

ctcagcccat cgcatggggc cagccgggtc tctttcctgc cactcagcag ccctggccaa   1740

ctgtggccgg gcagtttccg ccagccgcct tcatgcccac acaaactgtt atgcctttgc   1800

cagctgccat gttccaaggt cccctcaccc cccttgccac cgtcccaggc acgagtgact   1860

ccaccaggtc aagtccacag accgacaagc ccaggcagaa aatgggcaaa gaaacgttta   1920

aggatttcca gatggcccag cctccgcccg tgccctcccg caaacccgac cagccctccc   1980

tcacctgtac ctcagaggcc ttctccagtt acttcaacaa agtcggggtg gcacaggata   2040

cagacgactg tgatgacttt gacatctccc agttgaattt gacccctgtg acttctacca   2100

caccatcgac caactcacct ccaaccccag cccctagaca gagctctcca tccaaatcat   2160

ctgcatccca tgccagtgat cctaccacag atgacatctt tgaagagggc tttgaaagtc   2220

ccagcaaaag cgaagagcaa gaagctcctg atggatcaca ggcctcatcc aacagtgatc   2280

catttggtga gcccagtggg gagcccagtg gtgataatat aagtccacag gccggtagct   2340

agatagcgca ggtctgggag ccagagcctc tgtacgcgca gatcaacaga cctaagaaat   2400

agcatcgatg cgagctcgtg gtgggtgctc aagactggca tggacatcag catcacgaca   2460

ggctctcttg tattctttca cctcttccca caagaaattc atgattgccc aatggaactc   2520

gctcagaaga gggaactaag catttttggc aaccaatggc agatatctat ggcagcacac   2580


<210>  1807
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  1807

Met Ser Thr Glu Thr Glu Leu Gln Val Ala Val Lys Thr Ser Ala Lys 
1               5                   10                  15


Lys Asp Ser Arg Lys Lys Gly Gln Asp Arg Ser Glu Ala Thr Leu Ile 
            20                  25                  30


Lys Arg Phe Lys Gly Glu Gly Val Arg Tyr Lys Ala Lys Leu Ile Gly 
        35                  40                  45


Ile Asp Glu Val Ser Ala Ala Arg Gly Asp Lys Leu Cys Gln Asp Ser 
    50                  55                  60


Met Met Lys Leu Lys Gly Val Val Ala Gly Ala Arg Ser Lys Gly Glu 
65                  70                  75                  80


His Lys Gln Lys Ile Phe Leu Thr Ile Ser Phe Gly Gly Ile Lys Ile 
                85                  90                  95


Phe Asp Glu Lys Thr Gly Ala Leu Gln His His His Ala Val His Glu 
            100                 105                 110


Ile Ser Tyr Ile Ala Lys Asp Ile Thr Asp His Arg Ala Phe Gly Tyr 
        115                 120                 125


Val Cys Gly Lys Glu Gly Asn His Arg Phe Val Ala Ile Lys Thr Ala 
    130                 135                 140


Gln Ala Ala Glu Pro Val Ile Leu Asp Leu Arg Asp Leu Phe Gln Leu 
145                 150                 155                 160


Ile Tyr Glu Leu Lys Gln Arg Glu Glu Leu Glu Lys Lys Ala Gln Lys 
                165                 170                 175


Asp Lys Gln Cys Glu Gln Ala Val Tyr Gln Thr Ile Leu Glu Glu Asp 
            180                 185                 190


Val Glu Asp Pro Val Tyr Gln Tyr Ile Val Phe Glu Ala Gly His Glu 
        195                 200                 205


Pro Ile Arg Asp Pro Glu Thr Glu Glu Asn Ile Tyr Gln Val Pro Thr 
    210                 215                 220


Ser Gln Lys Lys Glu Gly Val Tyr Asp Val Pro Lys Ser Gln Pro Val 
225                 230                 235                 240


Ser Ala Val Thr Gln Leu Glu Leu Phe Gly Asp Met Ser Thr Pro Pro 
                245                 250                 255


Asp Ile Thr Ser Pro Pro Thr Pro Ala Thr Pro Gly Asp Ala Phe Ile 
            260                 265                 270


Pro Ser Ser Ser Gln Thr Leu Pro Ala Ser Ala Asp Val Phe Ser Ser 
        275                 280                 285


Val Pro Phe Gly Thr Ala Ala Val Pro Ser Gly Tyr Val Ala Met Gly 
    290                 295                 300


Ala Val Leu Pro Ser Phe Trp Gly Gln Gln Pro Leu Val Gln Gln Gln 
305                 310                 315                 320


Met Val Met Gly Ala Gln Pro Pro Val Ala Gln Val Met Pro Gly Ala 
                325                 330                 335


Gln Pro Ile Ala Trp Gly Gln Pro Gly Leu Phe Pro Ala Thr Gln Gln 
            340                 345                 350


Pro Trp Pro Thr Val Ala Gly Gln Phe Pro Pro Ala Ala Phe Met Pro 
        355                 360                 365


Thr Gln Thr Val Met Pro Leu Pro Ala Ala Met Phe Gln Gly Pro Leu 
    370                 375                 380


Thr Pro Leu Ala Thr Val Pro Gly Thr Ser Asp Ser Thr Arg Ser Ser 
385                 390                 395                 400


Pro Gln Thr Asp Lys Pro Arg Gln Lys Met Gly Lys Glu Thr Phe Lys 
                405                 410                 415


Asp Phe Gln Met Ala Gln Pro Pro Pro Val Pro Ser Arg Lys Pro Asp 
            420                 425                 430


Gln Pro Ser Leu Thr Cys Thr Ser Glu Ala Phe Ser Ser Tyr Phe Asn 
        435                 440                 445


Lys Val Gly Val Ala Gln Asp Thr Asp Asp Cys Asp Asp Phe Asp Ile 
    450                 455                 460


Ser Gln Leu Asn Leu Thr Pro Val Thr Ser Thr Thr Pro Ser Thr Asn 
465                 470                 475                 480


Ser Pro Pro Thr Pro Ala Pro Arg Gln Ser Ser Pro Ser Lys Ser Ser 
                485                 490                 495


Ala Ser His Ala Ser Asp Pro Thr Thr Asp Asp Ile Phe Glu Glu Gly 
            500                 505                 510


Phe Glu Ser Pro Ser Lys Ser Glu Glu Gln Glu Ala Pro Asp Gly Ser 
        515                 520                 525


Gln Ala Ser Ser Asn Ser Asp Pro Phe Gly Glu Pro Ser Gly Glu Pro 
    530                 535                 540


Ser Gly Asp Asn Ile Ser Pro Gln Ala Gly Ser 
545                 550                 555


<210>  1808
<211>  2256
<212>  DNA
<213>  Homo sapiens

<400>  1808
agtgatgtat aaggtatgaa agatgtggcc tgcagagagc cggcactatc tctactgctg     60

ctgctgctgc tactgctgct gttgctaccg ctgcctctgc tgccaccgcc actactgctg    120

ccagcggagc cgctaggagt gagcatcccc tctccgggat acccagctcc gcggcgtctc    180

ccgcgcgccc tggccccaca cggacctgcc agccccaggg aacaaaagcg gagcccgctc    240

gccctctact gcagccggag gatgagtcga gagggctgag cggagagtgt ggtcctcggc    300

ggctggagga aattgtgggt ttcttggaag gctctggata tctgtgacag acctcaggga    360

cacagataat ttgaaaattg catgctattt ccttggcttc tctccatgac gattcctgac    420

tcgtggcccc ggcaatcttg ggaagacatc atccagcttc ttcagtccag accctgggca    480

cccccctttt gccaggatcg tccccaccca gcctggacac attgactgaa ctgttttcta    540

ggacactgca ctcagcaaga catggtggtg agccctgact ctcagtcttc atgattgaag    600

aactcttttg tacaacacaa agcactcaaa aagagtgaat gaaatgtgca gctcagagtg    660

tcatttctga agggaggagt ctttctcttg gagaagagtc ctcaatgagc ctggccgagg    720

cccgggatct gtgtgaagtg gactaaggat taagtaggat gtcaactgag acagaacttc    780

aagtagctgt gaaaaccagc gccaagaaag actccagaaa gaaaggtcag gatcgcagtg    840

aagccacttt gataaagagg tttaaaggtg aaggggtccg gtacaaagcc aaattgatcg    900

ggattgatga agtttccgca gctcggggag acaagttatg tcaagattcc atgatgaaac    960

tcaaggtgct atgcaaacgt tttcttttca atactttgtg tttaatgtga atgaggaaaa   1020

gaagtgatta ccatcataat tgtaaataac tttattcatt tattggtaaa ttacttggct   1080

tactgttgaa tcaccatatt ttttcattcg gaagatattt caatcattca gcaaatgttt   1140

gttgagcacc tactatgtgg aaatattttg gtaggcccag gtttacaatt tttgagtgta   1200

tcacatttta ttccatttta ttttcatttt gcaactcctg caaaaataaa agcaaaaaat   1260

tatcaaattg ttttgtcacc cacattttat gaattttgcc atcttgttat ttttgaataa   1320

ataatatata tttttgccat atggtaagag atgttaagat aaaagttgat tttattcatt   1380

cttacagttt ctacaaatgt accccaagca ctttaagata atatccttaa agtaaaatgt   1440

aattatattt tgggatttgg ggatatcatg aagagatttc tgattttaaa tgctataaag   1500

aagccttttc tctgaggaat ctaagaaaga aattagattt tttttttctt tttttttttt   1560

tgagaaggag tctcactcta tcgcctaggc tggagtgcag tggcgcaatc tcggctcact   1620

gcaacttccg cctcctgggt tcaagcaatt ctcctgcctc agcctcctga gtagctggga   1680

ttacaggtgc acactaccag gcctggctaa tttttgtatt tttagtagag acggggtttc   1740

accatgttgg tcaggctggt ctcgaactcc tgacctcatg atccgtccgc ctcggcctcc   1800

caaagtgctg ggattacagg cgtgagccac tgtgcccggc cagaaattag aaatttttta   1860

aatatacaaa ataaattatt ttattaaaca tccttaaaag catacaaaaa taacactttt   1920

ctcagattct gatgtccata tattgtttct tttaaaaagt tataaaatat tgaaaaaata   1980

aatggtttag caagaagtat acaaatatca tatgtatttc aaacatatat tatttatttt   2040

tctgattaca gagttcactt atgtgcatta tggaatattt tgaaaataca gaaaaatgta   2100

aggaagaaaa ctgaaataat ccacaatccc acaaagacaa tcagtgtcaa tatttttgtg   2160

tataatttac aagttctttt tgtggtttta catatataat atatgaatta tacacatata   2220

tgtaataaaa ttggaattaa aatttataca gtttcc                             2256


<210>  1809
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  1809

Met Ser Thr Glu Thr Glu Leu Gln Val Ala Val Lys Thr Ser Ala Lys 
1               5                   10                  15


Lys Asp Ser Arg Lys Lys Gly Gln Asp Arg Ser Glu Ala Thr Leu Ile 
            20                  25                  30


Lys Arg Phe Lys Gly Glu Gly Val Arg Tyr Lys Ala Lys Leu Ile Gly 
        35                  40                  45


Ile Asp Glu Val Ser Ala Ala Arg Gly Asp Lys Leu Cys Gln Asp Ser 
    50                  55                  60


Met Met Lys Leu Lys Val Leu Cys Lys Arg Phe Leu Phe Asn Thr Leu 
65                  70                  75                  80


Cys Leu Met 



<210>  1810
<211>  583
<212>  DNA
<213>  Homo sapiens

<400>  1810
atgaaagatg tggcctgcag agagccggca ctatctctac tgctgctgct gctgctactg     60

ctgctgttgc taccgctgcc tctgctgcca ccgccactac tgctgccagc ggagccgcta    120

ggagtgagca tcccctctcc gggataccca gctccgcggc gtctcccgcg cgccctggcc    180

ccacacggac ctgccagccc cagggaacaa aagcggagcc cgctcgccct ctactgcagc    240

cggaggatga gtcgagaggg ctgagcggag agtgtggtcc tcggcggctg gagctatttc    300

cttggcttct ctccatgacg attcctgact cgtggccccg gcaatcttgg gaagacatca    360

tccagcttct tcagtccaga ccctgggcac cccccttttg ccaggatcgt ccccacccag    420

cctggacaca ttgactgaac tgttttctag gacactgcac tcagcaagac atggtggtga    480

gccctgactc tcagtcttca tgattgaaga actcttttgt acaacacaaa ggaagcctcc    540

agccacacac cagatcacga gggttagagg tcccagcctg tca                      583


<210>  1811
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  1811

Met Lys Asp Val Ala Cys Arg Glu Pro Ala Leu Ser Leu Leu Leu Leu 
1               5                   10                  15


Leu Leu Leu Leu Leu Leu Leu Leu Pro Leu Pro Leu Leu Pro Pro Pro 
            20                  25                  30


Leu Leu Leu Pro Ala Glu Pro Leu Gly Val Ser Ile Pro Ser Pro Gly 
        35                  40                  45


Tyr Pro Ala Pro Arg Arg Leu Pro Arg Ala Leu Ala Pro His Gly Pro 
    50                  55                  60


Ala Ser Pro Arg Glu Gln Lys Arg Ser Pro Leu Ala Leu Tyr Cys Ser 
65                  70                  75                  80


Arg Arg Met Ser Arg Glu Gly 
                85


<210>  1812
<211>  587
<212>  DNA
<213>  Homo sapiens

<400>  1812
agtgatgtat aaggtatgaa agatgtggcc tgcagagagc cggcactatc tctactgctg     60

ctgctgctgc tactgctgct gttgctaccg ctgcctctgc tgccaccgcc actactgctg    120

ccagcggagc cgctaggagt gagcatcccc tctccgggat acccagctcc gcggcgtctc    180

ccgcgcgccc tggccccaca cggacctgcc agccccaggg aacaaaagcg gagcccgctc    240

gccctctact gcagccggag gatgagtcga gagggctgag cggagagtgt ggtcctcggc    300

ggctggagct atttccttgg cttctctcca tgacgattcc tgactcgtgg ccccggcaat    360

cttgggaaga catcatccag cttcttcagt ccagaccctg ggcacccccc ttttgccagg    420

atcgtcccca cccagcctgg acacattgac tgaactgttt tctaggacac tgctcttgga    480

ttgttttact ggattctttg gattggtttc aattttctcc tgaatctcat tgagcttcct    540

tgtcatccag attctgaact ctatgtctgt catttcagtc tgattga                  587


<210>  1813
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  1813

Met Lys Asp Val Ala Cys Arg Glu Pro Ala Leu Ser Leu Leu Leu Leu 
1               5                   10                  15


Leu Leu Leu Leu Leu Leu Leu Leu Pro Leu Pro Leu Leu Pro Pro Pro 
            20                  25                  30


Leu Leu Leu Pro Ala Glu Pro Leu Gly Val Ser Ile Pro Ser Pro Gly 
        35                  40                  45


Tyr Pro Ala Pro Arg Arg Leu Pro Arg Ala Leu Ala Pro His Gly Pro 
    50                  55                  60


Ala Ser Pro Arg Glu Gln Lys Arg Ser Pro Leu Ala Leu Tyr Cys Ser 
65                  70                  75                  80


Arg Arg Met Ser Arg Glu Gly 
                85


<210>  1814
<211>  459
<212>  DNA
<213>  Homo sapiens

<400>  1814
tctctctggt ccgtgcctcc aagatgacaa agaaaagaag gaacaatggt cgtgccaaaa     60

agggccgcgg ccacgtgcag cctattcgct gcactaactg tgcccgatgc gtgcccaagg    120

acaaggccat taagacattc gtcattcgaa acatagtgaa ggccgcagca gtcagggaca    180

tttctgaagc gagcgtcttc gatgcctatg tgcttcccaa gctgtatgtg aagctacatt    240

actgtgtgag ttgtgcaatt cacagcaaag tagtcaggaa tcgatctcgt gaagcccgca    300

aggaccgaac acccccatcc cgatttagac ctgcgggtgc tgccccacgt cccccaccaa    360

agcccatgta aggagctgag ttcttaaaga ctgaagacag gctattctct ggagaaaaat    420

aaaatggaaa ttgtacttaa aaaaaaaaaa aaaagaatg                           459


<210>  1815
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  1815

Met Thr Lys Lys Arg Arg Asn Asn Gly Arg Ala Lys Lys Gly Arg Gly 
1               5                   10                  15


His Val Gln Pro Ile Arg Cys Thr Asn Cys Ala Arg Cys Val Pro Lys 
            20                  25                  30


Asp Lys Ala Ile Lys Thr Phe Val Ile Arg Asn Ile Val Lys Ala Ala 
        35                  40                  45


Ala Val Arg Asp Ile Ser Glu Ala Ser Val Phe Asp Ala Tyr Val Leu 
    50                  55                  60


Pro Lys Leu Tyr Val Lys Leu His Tyr Cys Val Ser Cys Ala Ile His 
65                  70                  75                  80


Ser Lys Val Val Arg Asn Arg Ser Arg Glu Ala Arg Lys Asp Arg Thr 
                85                  90                  95


Pro Pro Ser Arg Phe Arg Pro Ala Gly Ala Ala Pro Arg Pro Pro Pro 
            100                 105                 110


Lys Pro Met 
        115


<210>  1816
<211>  618
<212>  DNA
<213>  Homo sapiens

<400>  1816
aggaaggatg gcaaaggagc caaagatcag gcgagtccag gccaaggagt ccgcacatct     60

ctcataggca gtaggggctc acccaccgaa tgaagtggtt ggatctgcag tttaagaaga    120

aaaccaaaag ccaactcttt ccaacaggct tctctgctgg ctctctaagg tgatgccaac    180

caaacatgga ggttgcctta aagcattaac ctgagtctga agaatgaaca catggaaatg    240

atgctcatga tgaggttaat aatcacacaa aaagaataat tctgagatta gcaatttaca    300

actacctttg ggcatgcctg ctggccccag ggaaggagag aggagaatcc aagaaggtcc    360

tggaaagtta ccagaaagga tgagtttcga ggcagttgca tgtaaatgtg gcttagccaa    420

tgggaaagga agggatatgt gtcctggtac aggtatttga gaaatgtaca gtccatctgt    480

taaggtgtgc tcaaccccca accattgtcc acacttcagt gacttaatca gtagagaccc    540

caaattcatg tccagtgact ttgacatctt cgagctgaag gactgatctc tcattttttc    600

aataacactt tatgactt                                                  618


<210>  1817
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  1817

Met Pro Ala Gly Pro Arg Glu Gly Glu Arg Arg Ile Gln Glu Gly Pro 
1               5                   10                  15


Gly Lys Leu Pro Glu Arg Met Ser Phe Glu Ala Val Ala Cys Lys Cys 
            20                  25                  30


Gly Leu Ala Asn Gly Lys Gly Arg Asp Met Cys Pro Gly Thr Gly Ile 
        35                  40                  45


<210>  1818
<211>  630
<212>  DNA
<213>  Homo sapiens

<400>  1818
agcgttccct ggggcctagc caaccgcggg cagggctggg caaggcggga ggagcgcgga     60

cccaagatcg gctacgctgc gtctgctcag gctgcgagtt cccggctctg gggactcacc    120

ttgcggagct tacccaggcg gactctccgc agcccctgat gggtgtgtgt gtcagaccgt    180

ttactaaaca ccaggactgt tgtaggcgac tcagccgtgt tgaaccatga aaggacctca    240

ggaatgaaac ccacacacag caaagcaaca aagtgaaaga agcgtggatt cctaatgcag    300

gaggcactga accaatcaat acccactgcc ctccagacct ccacatgaaa gaaaaaaact    360

gctgtcctgt gaagaagaca ctccccagat gccagcaact tgatattgga cttcctgcct    420

ttagaaacat tcctttaagc ctctctgaaa cttgaccctc tggcaggaac aggtgccatt    480

acatacagac actctctctc ttccaaattc accctgtcat atcaaaggga aaactgaagt    540

ggtccactgt agacctgaca gatgatcaca aacaggaaac cagcaatcag aagtgcctac    600

tgagctccct accctgacca tcacctacag                                     630


<210>  1819
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  1819

Met Lys Glu Lys Asn Cys Cys Pro Val Lys Lys Thr Leu Pro Arg Cys 
1               5                   10                  15


Gln Gln Leu Asp Ile Gly Leu Pro Ala Phe Arg Asn Ile Pro Leu Ser 
            20                  25                  30


Leu Ser Glu Thr 
        35


<210>  1820
<211>  1038
<212>  DNA
<213>  Homo sapiens

<400>  1820
gcgtctgctc aggctgcgag ttcccggctc tggggactca ccttgcggag cttacccagg     60

cggactctcc gcagcccctg atgggtgtgt gtgtcagacc gtttactaaa caccaggact    120

gttgtaggcg actaacatta tgaagaacaa atgtggtaag acatatgaaa atgctttgta    180

aagtgttaga tgcttaatac acagaagaca ttgcttccag atctgtttca acgtacccca    240

agaatggaat aagtggaata tgctggtttc atgcactgtg gcaagggggt ctcatcttgg    300

ctagacttga ataagtggat ttgttgcctg gcctctgtgg atggctcttt ctctgggctt    360

ttgtgtattt gattttttat ttgctccagc agccgtgttg aaccatgaaa ggacctcagg    420

aatgaaaccc acacacagca aagcaacaaa gtgaaagaag cgtggattcc taatgcagga    480

ggcactgaac caatcaatac ccactgccct ccagacctcc acatgaaaga aaaaaactgc    540

tgtcctgtgt aagacacttt tattttgtgt ttctattgta tgaggtcaaa cctaataaca    600

gatatattac actctaacag atacattaca ttgtatagta gaattctcag acagcaacct    660

tataaggtga tagatgcaga aacaggccca aagagtaaaa ataatttgtt cagagttttc    720

cagccaagtg gcgaaggtga gattcttacc tgggtttgtc tgaaaccaat tttcactatc    780

tttttcagtt atgatacact gcctattacg aatgaatgaa tccttttttt tttttccatt    840

tacttccatt tgattcattt attccaggga gtgacacttt ttctgtaaag gaccgatagt    900

aaatatttta gactttgtga gcaatacagt ctctgttgca actactcaac tttgtaatgt    960

aaaagcagcc atagacaata gtaaatgagt aggtatgact atgtttcaat aaaactttac   1020

ttacacaagc aggcaatg                                                 1038


<210>  1821
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  1821

Met Arg Ser Asn Leu Ile Thr Asp Ile Leu His Ser Asn Arg Tyr Ile 
1               5                   10                  15


Thr Leu Tyr Ser Arg Ile Leu Arg Gln Gln Pro Tyr Lys Val Ile Asp 
            20                  25                  30


Ala Glu Thr Gly Pro Lys Ser Lys Asn Asn Leu Phe Arg Val Phe Gln 
        35                  40                  45


Pro Ser Gly Glu Gly Glu Ile Leu Thr Trp Val Cys Leu Lys Pro Ile 
    50                  55                  60


Phe Thr Ile Phe Phe Ser Tyr Asp Thr Leu Pro Ile Thr Asn Glu 
65                  70                  75


<210>  1822
<211>  553
<212>  DNA
<213>  Homo sapiens

<400>  1822
gtgggattgg ccgtcgcctg cccaccccgc ggctgcagcg ttccctgggg cctagccaac     60

cgcgggcagg gctgggcaag gcgggaggag cgcggaccca agatcggcta cgctgcgtct    120

gctcaggctg cgagttcccg gctctgggga ctcaccttgc ggagcttacc caggcggact    180

ctccgcagcc cctgatgggt gtgtgtgtca gaccgtttac taaacaccag gactgttgta    240

ggcgactaaa agaaaactga gatccaggaa agggaagtga ttttccaaag acacacctgt    300

gaaaggtgag gagaacagcc cagtgaggct gaggccacac aattaacccc agtctttgca    360

ctacaactct accagggatc ctggtttggc tcattttctt tcttctgcac catgattgtt    420

caccttttca ttaccagcaa catacccaaa gacctagcta tagactcgtt ggaatctgtt    480

acttagcagc tgtgtgaatc aagtgttcaa taggaataat aagatgtatt catcttacct    540

tttcagaaca tta                                                       553


<210>  1823
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  1823

Val Gly Leu Ala Val Ala Cys Pro Pro Arg Gly Cys Ser Val Pro Trp 
1               5                   10                  15


Gly Leu Ala Asn Arg Gly Gln Gly Trp Ala Arg Arg Glu Glu Arg Gly 
            20                  25                  30


Pro Lys Ile Gly Tyr Ala Ala Ser Ala Gln Ala Ala Ser Ser Arg Leu 
        35                  40                  45


Trp Gly Leu Thr Leu Arg Ser Leu Pro Arg Arg Thr Leu Arg Ser Pro 
    50                  55                  60


<210>  1824
<211>  563
<212>  DNA
<213>  Homo sapiens

<400>  1824
ggccgcgctt tacaggggcc gcgctttaca ggggccgcgc tttacagggg ccgcgcttta     60

caggggccgc gctttacagg ggccgcgctt tacaggggcc gcgctttaca ggggccgcgc    120

tttacagggg ccgcgccggc gggggcggga tcgcgcgcaa ggcggggctg tagccgcccc    180

gggaccgccc tgctcaggcg ccgtggggtt cggcgcggct acgtgcagaa tccgtctagc    240

taaaatgtaa tttcagattg gacaagtact agagggagtc aaaagtgagg aacccaagcc    300

tgagcacgtg ggccagcccc atggggaatc tgtcttgtca tcggggctgg ctggagtaga    360

gacaagtctg gatgctggct ggccaggtgg aggaactgca atgtctggtg gagaacagaa    420

accagagagg tactatgtgg gtgtggacgt tggaacaggc agtgtccgtg cagctctggt    480

ggaccagagt ggggtcctgt tggcttttgc agaccagcca attaagaatt gggagcccca    540

gttcaaccac catgagcagt cct                                            563


<210>  1825
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  1825

Met Leu Ala Gly Gln Val Glu Glu Leu Gln Cys Leu Val Glu Asn Arg 
1               5                   10                  15


Asn Gln Arg Gly Thr Met Trp Val Trp Thr Leu Glu Gln Ala Val Ser 
            20                  25                  30


Val Gln Leu Trp Trp Thr Arg Val Gly Ser Cys Trp Leu Leu Gln Thr 
        35                  40                  45


Ser Gln Leu Arg Ile Gly Ser Pro Ser Ser Thr Thr Met Ser Ser 
    50                  55                  60


<210>  1826
<211>  775
<212>  DNA
<213>  Homo sapiens

<400>  1826
ggccgcgctt tacaggggcc gcgctttaca ggggccgcgc tttacagggg ccgcgcttta     60

caggggccgc gctttacagg ggccgcgctt tacaggggcc gcgctttaca ggggccgcgc    120

tttacagggg ccgcgccggc gggggcggga tcgcgcgcaa ggcggggctg tagccgcccc    180

gggaccgccc tgctcaggcg ccgtggggtt cggcgcggct acgtgcagaa tccgtctagc    240

taaaatgtaa tttcagattg gacaagtact aaagttgtac aagggattga tttaaaccaa    300

attcgaggac ttgggtttga tgccacgtgt tctctggttg ttttggataa gcagtttcac    360

ccattaccag tcaaccagga aggggattcc catcgaaacg tcatcatgtg gctggaccat    420

cgagcagtca gtcaagttaa caggatcaat gagaccaagc acagtgtcct ccagtacgtc    480

gggggggtga tgtctgtgga aatgcaggcc ccgaaacttc tgtggctgaa agagaacttg    540

agagagattt gctgggataa ggcgggacat ttctttgatc tcccggactt cttatcgtgg    600

aaggcaacag gtgtcacagc acggtctctc tgctccctgg tgtgtaagtg gacatattca    660

gcagagaaag gctgggacga cagtttctgg aaaatgattg gtttggaaga ctttgttgca    720

gataattaca gcaaaatagg taaaagaata aaacatctgt agagtgatta tgtgc         775


<210>  1827
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  1827

Met Trp Leu Asp His Arg Ala Val Ser Gln Val Asn Arg Ile Asn Glu 
1               5                   10                  15


Thr Lys His Ser Val Leu Gln Tyr Val Gly Gly Val Met Ser Val Glu 
            20                  25                  30


Met Gln Ala Pro Lys Leu Leu Trp Leu Lys Glu Asn Leu Arg Glu Ile 
        35                  40                  45


Cys Trp Asp Lys Ala Gly His Phe Phe Asp Leu Pro Asp Phe Leu Ser 
    50                  55                  60


Trp Lys Ala Thr Gly Val Thr Ala Arg Ser Leu Cys Ser Leu Val Cys 
65                  70                  75                  80


Lys Trp Thr Tyr Ser Ala Glu Lys Gly Trp Asp Asp Ser Phe Trp Lys 
                85                  90                  95


Met Ile Gly Leu Glu Asp Phe Val Ala Asp Asn Tyr Ser Lys Ile Gly 
            100                 105                 110


Lys Arg Ile Lys His Leu 
        115


<210>  1828
<211>  1799
<212>  DNA
<213>  Homo sapiens

<400>  1828
gctggtgcgc aggctcttag cgcgcacgcc cagaaagagg cttctccaac ccggcccggc     60

ccttccttcc cctttcccgc agtcgttgcc tcctcctccc ctgcctcctc ctccccttcc    120

tcctcctggc cgcttagtct cacacccgcc gggccgttgt tcccgagacg ttgttgagtc    180

ccctgtgtcc tcttctggaa agttgtacaa gggattgatt taaaccaaat tcgaggactt    240

gggtttgatg ccacgtgttc tctggttgtt ttggataagc agtttcaccc attaccagtc    300

aaccaggaag gggattccca tcgaaacgtc atcatgtggc tggaccatcg agcagtcagt    360

caagttaaca ggatcaatga gaccaagcac agtgtcctcc agtacgtcgg gggggtgatg    420

tctgtggaaa tgcaggcccc gaaacttctg tggctgaaag agaacttgag agagatttgc    480

tgggataagg cgggacattt ctttgatctc ccggacttct tatcgtggaa ggcaacaggt    540

gtcacagcac ggtctctctg ctccctggtg tgtaagtgga catattcagc agagaaaggc    600

tgggacgaca gtttctggaa aatgattggt ttggaagact ttgttgcaga taattacagc    660

aaaataggaa accaagtgct acctcctgga gcttctcttg gaaatgggct cacaccagag    720

gcagcaagag accttggcct tctccctggg attgcggtcg cagcttcact cattgatgcc    780

catgcaggag gactaggagt gattggggca gatgtgagag ggcacggcct catctgtgag    840

gggcagccag tgacgtcacg gctggctgtc atctgtggaa cgtcttcttg tcacatgggg    900

atcagcaaag acccgatttt tgtaccaggc gtctgggggc cttatttctc agccatggta    960

cctgggttct ggctgaatga aggtggtcag agcgttactg gaaaattgat agaccacatg   1020

gtacaaggcc atgctgcttt tccagaacta caagtaaagg ccacagccag atgccagagt   1080

atatatgcat atttgaacag tcacctggat ctgattaaga aggctcagcc tgtgggtttc   1140

cttactgttg atttacatgt ttggccagat ttccatggca accggtctcc cttagcagat   1200

ctgacactaa agggcatggt caccggattg aaactgtctc aggaccttga tgatcttgcc   1260

attctctacc tggccacagt tcaagccatt gctttgggga ctcgcttcat tatagaagcc   1320

atggaggcag cagggcactc aatcagtact cttttcctat gtggaggcct cagcaagaat   1380

cccctttttg tgcaaatgca tgcggacatt actggcatgc ctgtggtcct gtcgcaagag   1440

gtggagtccg ttcttgtggg tgctgctgtt ctgggtgcct gtgcctcagg ggatttcgct   1500

tctgtacagg aagcaatggc aaaaatgagc aaagttggga aagttgtgtt cccgagacta   1560

caggataaaa aatactatga taagaaatac caagtattcc tgaagctggt tgaacaccag   1620

aaggagtatt tggcgatcat gaatgatgac tgaacagggc ttgcaggtgc tgatgccaga   1680

agcttctgtg ccattgcatt aaagacttgt catttgatcc atgttcaaga cccttgaggt   1740

attgtttcat catttctgta ttgtctttca ataaagaaaa caaacatgtg caaccagaa    1799


<210>  1829
<211>  439
<212>  PRT
<213>  Homo sapiens

<400>  1829

Met Trp Leu Asp His Arg Ala Val Ser Gln Val Asn Arg Ile Asn Glu 
1               5                   10                  15


Thr Lys His Ser Val Leu Gln Tyr Val Gly Gly Val Met Ser Val Glu 
            20                  25                  30


Met Gln Ala Pro Lys Leu Leu Trp Leu Lys Glu Asn Leu Arg Glu Ile 
        35                  40                  45


Cys Trp Asp Lys Ala Gly His Phe Phe Asp Leu Pro Asp Phe Leu Ser 
    50                  55                  60


Trp Lys Ala Thr Gly Val Thr Ala Arg Ser Leu Cys Ser Leu Val Cys 
65                  70                  75                  80


Lys Trp Thr Tyr Ser Ala Glu Lys Gly Trp Asp Asp Ser Phe Trp Lys 
                85                  90                  95


Met Ile Gly Leu Glu Asp Phe Val Ala Asp Asn Tyr Ser Lys Ile Gly 
            100                 105                 110


Asn Gln Val Leu Pro Pro Gly Ala Ser Leu Gly Asn Gly Leu Thr Pro 
        115                 120                 125


Glu Ala Ala Arg Asp Leu Gly Leu Leu Pro Gly Ile Ala Val Ala Ala 
    130                 135                 140


Ser Leu Ile Asp Ala His Ala Gly Gly Leu Gly Val Ile Gly Ala Asp 
145                 150                 155                 160


Val Arg Gly His Gly Leu Ile Cys Glu Gly Gln Pro Val Thr Ser Arg 
                165                 170                 175


Leu Ala Val Ile Cys Gly Thr Ser Ser Cys His Met Gly Ile Ser Lys 
            180                 185                 190


Asp Pro Ile Phe Val Pro Gly Val Trp Gly Pro Tyr Phe Ser Ala Met 
        195                 200                 205


Val Pro Gly Phe Trp Leu Asn Glu Gly Gly Gln Ser Val Thr Gly Lys 
    210                 215                 220


Leu Ile Asp His Met Val Gln Gly His Ala Ala Phe Pro Glu Leu Gln 
225                 230                 235                 240


Val Lys Ala Thr Ala Arg Cys Gln Ser Ile Tyr Ala Tyr Leu Asn Ser 
                245                 250                 255


His Leu Asp Leu Ile Lys Lys Ala Gln Pro Val Gly Phe Leu Thr Val 
            260                 265                 270


Asp Leu His Val Trp Pro Asp Phe His Gly Asn Arg Ser Pro Leu Ala 
        275                 280                 285


Asp Leu Thr Leu Lys Gly Met Val Thr Gly Leu Lys Leu Ser Gln Asp 
    290                 295                 300


Leu Asp Asp Leu Ala Ile Leu Tyr Leu Ala Thr Val Gln Ala Ile Ala 
305                 310                 315                 320


Leu Gly Thr Arg Phe Ile Ile Glu Ala Met Glu Ala Ala Gly His Ser 
                325                 330                 335


Ile Ser Thr Leu Phe Leu Cys Gly Gly Leu Ser Lys Asn Pro Leu Phe 
            340                 345                 350


Val Gln Met His Ala Asp Ile Thr Gly Met Pro Val Val Leu Ser Gln 
        355                 360                 365


Glu Val Glu Ser Val Leu Val Gly Ala Ala Val Leu Gly Ala Cys Ala 
    370                 375                 380


Ser Gly Asp Phe Ala Ser Val Gln Glu Ala Met Ala Lys Met Ser Lys 
385                 390                 395                 400


Val Gly Lys Val Val Phe Pro Arg Leu Gln Asp Lys Lys Tyr Tyr Asp 
                405                 410                 415


Lys Lys Tyr Gln Val Phe Leu Lys Leu Val Glu His Gln Lys Glu Tyr 
            420                 425                 430


Leu Ala Ile Met Asn Asp Asp 
        435


<210>  1830
<211>  2058
<212>  DNA
<213>  Homo sapiens

<400>  1830
cccagaaaga ggcttctcca acccggcccg gcccttcctt cccctttccc gcagtcgttg     60

cctcctcctc ccctgcctcc tcctcccctt cctcctcctg gccgcttagt ctcacacccg    120

ccgggccgtt gttcccgaga cgttgttgag tcccctgtgt cctcttctgg gtggaggaac    180

tgcaatgtct ggtggagaac agaaaccaga gaggtactat gtgggtgtgg acgttggaac    240

aggcagtgtc cgtgcagctc tggtggacca gagtggggtc ctgttggctt ttgcagacca    300

gccaattaag aattgggagc cccagttcaa ccaccatgag cagtcctccg aggacatctg    360

ggctgcgtgc tgtgttgtca caaagaaagt tgtacaaggg attgatttaa accaaattcg    420

aggacttggg tttgatgcca cgtgttctct ggttgttttg gataagcagt ttcacccatt    480

accagtcaac caggaagggg attcccatcg aaacgtcatc atgtggctgg accatcgagc    540

agtcagtcaa gttaacagga tcaatgagac caagcacagt gtcctccagt acgtcggggg    600

ggtgatgtct gtggaaatgc aggccccgaa acttctgtgg ctgaaagaga acttgagaga    660

gatttgctgg gataaggcgg gacatttctt tgatctcccg gacttcttat cgtggaaggc    720

aacaggtgtc acagcacggt ctctctgctc cctggtgtgt aagtggacat attcagcaga    780

gaaaggctgg gacgacagtt tctggaaaat gattggtttg gaagactttg ttgcagataa    840

ttacagcaaa ataggaaacc aagtgctacc tcctggagct tctcttggaa atgggctcac    900

accagaggca gcaagagacc ttggccttct ccctgggatt gcggtcgcag cttcactcat    960

tgatgcccat gcaggaggac taggagtgat tggggcagat gtgagagggc acggcctcat   1020

ctgtgagggg cagccagtga cgtcacggct ggctgtcatc tgtggaacgt cttcttgtca   1080

catggggatc agcaaagacc cgatttttgt accaggcgtc tgggggcctt atttctcagc   1140

catggtacct gggttctggc tgaatgaagg tggtcagagc gttactggaa aattgataga   1200

ccacatggta caaggccatg ctgcttttcc agaactacaa gtaaaggcca cagccagatg   1260

ccagagtata tatgcatatt tgaacagtca cctggatctg attaagaagg ctcagcctgt   1320

gggtttcctt actgttgatt tacatgtttg gccagatttc catggcaacc ggtctccctt   1380

agcagatctg acactaaagg gcatgagaac cactggatat ctgtatattc cggctttggc   1440

agcgttgcac tctcccagtt ctctactctc ccctcaggtc accggattga aactgtctca   1500

ggaccttgat gatcttgcca ttctctacct ggccacagtt caagccattg ctttggggac   1560

tcgcttcatt atagaagcca tggaggcagc agggcactca atcagtactc ttttcctatg   1620

tggaggcctc agcaagaatc ccctttttgt gcaaatgcat gcggacatta ctggcatgcc   1680

tgtggtcctg tcgcaagagg tggagtccgt tcttgtgggt gctgctgttc tgggtgcctg   1740

tgcctcaggg gatttcgctt ctgtacagga agcaatggca aaaatgagca aagttgggaa   1800

agttgtgttc ccgagactac aggataaaaa atactatgat aagaaatacc aagtattcct   1860

gaagctggtt gaacaccaga aggagtattt ggcgatcatg aatgatgact gaacagggct   1920

tgcaggtgct gatgccagaa gcttctgtgc cattgcatta aagacttgtc atttgatcca   1980

tgttcaagac ccttgaggta ttgtttcatc atttctgtat tgtctttcaa taaagaaaac   2040

aaacatgtgc aaccagaa                                                 2058


<210>  1831
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  1831

Met Ser Gly Gly Glu Gln Lys Pro Glu Arg Tyr Tyr Val Gly Val Asp 
1               5                   10                  15


Val Gly Thr Gly Ser Val Arg Ala Ala Leu Val Asp Gln Ser Gly Val 
            20                  25                  30


Leu Leu Ala Phe Ala Asp Gln Pro Ile Lys Asn Trp Glu Pro Gln Phe 
        35                  40                  45


Asn His His Glu Gln Ser Ser Glu Asp Ile Trp Ala Ala Cys Cys Val 
    50                  55                  60


Val Thr Lys Lys Val Val Gln Gly Ile Asp Leu Asn Gln Ile Arg Gly 
65                  70                  75                  80


Leu Gly Phe Asp Ala Thr Cys Ser Leu Val Val Leu Asp Lys Gln Phe 
                85                  90                  95


His Pro Leu Pro Val Asn Gln Glu Gly Asp Ser His Arg Asn Val Ile 
            100                 105                 110


Met Trp Leu Asp His Arg Ala Val Ser Gln Val Asn Arg Ile Asn Glu 
        115                 120                 125


Thr Lys His Ser Val Leu Gln Tyr Val Gly Gly Val Met Ser Val Glu 
    130                 135                 140


Met Gln Ala Pro Lys Leu Leu Trp Leu Lys Glu Asn Leu Arg Glu Ile 
145                 150                 155                 160


Cys Trp Asp Lys Ala Gly His Phe Phe Asp Leu Pro Asp Phe Leu Ser 
                165                 170                 175


Trp Lys Ala Thr Gly Val Thr Ala Arg Ser Leu Cys Ser Leu Val Cys 
            180                 185                 190


Lys Trp Thr Tyr Ser Ala Glu Lys Gly Trp Asp Asp Ser Phe Trp Lys 
        195                 200                 205


Met Ile Gly Leu Glu Asp Phe Val Ala Asp Asn Tyr Ser Lys Ile Gly 
    210                 215                 220


Asn Gln Val Leu Pro Pro Gly Ala Ser Leu Gly Asn Gly Leu Thr Pro 
225                 230                 235                 240


Glu Ala Ala Arg Asp Leu Gly Leu Leu Pro Gly Ile Ala Val Ala Ala 
                245                 250                 255


Ser Leu Ile Asp Ala His Ala Gly Gly Leu Gly Val Ile Gly Ala Asp 
            260                 265                 270


Val Arg Gly His Gly Leu Ile Cys Glu Gly Gln Pro Val Thr Ser Arg 
        275                 280                 285


Leu Ala Val Ile Cys Gly Thr Ser Ser Cys His Met Gly Ile Ser Lys 
    290                 295                 300


Asp Pro Ile Phe Val Pro Gly Val Trp Gly Pro Tyr Phe Ser Ala Met 
305                 310                 315                 320


Val Pro Gly Phe Trp Leu Asn Glu Gly Gly Gln Ser Val Thr Gly Lys 
                325                 330                 335


Leu Ile Asp His Met Val Gln Gly His Ala Ala Phe Pro Glu Leu Gln 
            340                 345                 350


Val Lys Ala Thr Ala Arg Cys Gln Ser Ile Tyr Ala Tyr Leu Asn Ser 
        355                 360                 365


His Leu Asp Leu Ile Lys Lys Ala Gln Pro Val Gly Phe Leu Thr Val 
    370                 375                 380


Asp Leu His Val Trp Pro Asp Phe His Gly Asn Arg Ser Pro Leu Ala 
385                 390                 395                 400


Asp Leu Thr Leu Lys Gly Met Arg Thr Thr Gly Tyr Leu Tyr Ile Pro 
                405                 410                 415


Ala Leu Ala Ala Leu His Ser Pro Ser Ser Leu Leu Ser Pro Gln Val 
            420                 425                 430


Thr Gly Leu Lys Leu Ser Gln Asp Leu Asp Asp Leu Ala Ile Leu Tyr 
        435                 440                 445


Leu Ala Thr Val Gln Ala Ile Ala Leu Gly Thr Arg Phe Ile Ile Glu 
    450                 455                 460


Ala Met Glu Ala Ala Gly His Ser Ile Ser Thr Leu Phe Leu Cys Gly 
465                 470                 475                 480


Gly Leu Ser Lys Asn Pro Leu Phe Val Gln Met His Ala Asp Ile Thr 
                485                 490                 495


Gly Met Pro Val Val Leu Ser Gln Glu Val Glu Ser Val Leu Val Gly 
            500                 505                 510


Ala Ala Val Leu Gly Ala Cys Ala Ser Gly Asp Phe Ala Ser Val Gln 
        515                 520                 525


Glu Ala Met Ala Lys Met Ser Lys Val Gly Lys Val Val Phe Pro Arg 
    530                 535                 540


Leu Gln Asp Lys Lys Tyr Tyr Asp Lys Lys Tyr Gln Val Phe Leu Lys 
545                 550                 555                 560


Leu Val Glu His Gln Lys Glu Tyr Leu Ala Ile Met Asn Asp Asp 
                565                 570                 575


<210>  1832
<211>  1947
<212>  DNA
<213>  Homo sapiens

<400>  1832
agaaagaggc ttctccaacc cggcccggcc cttccttccc ctttcccgca gtcgttgcct     60

cctcctcccc tgcctcctcc tccccttcct cctcctggcc gcttagtctc acacccgccg    120

ggccgttgtt cccgagacgt tgttgagtcc cctgtgtcct cttctgggtg gaggaactgc    180

aatgtctggt ggagaacaga aaccagagag gtactatgtg ggtgtggacg ttggaacagg    240

cagtgtccgt gcagctctgg tggaccagag tggggtcctg ttggcttttg cagaccagcc    300

aattaagaat tgggagcccc agttcaacca ccatgagcag tcctccgagg acatctgggc    360

tgcgtgctgt gttgtcacaa aggggattcc catcgaaacg tcatcatgtg gctggaccat    420

cgagcagtca gtcaagttaa caggatcaat gagaccaagc acagtgtcct ccagtacgtc    480

gggggggtga tgtctgtgga aatgcaggcc ccgaaacttc tgtggctgaa agagaacttg    540

agagagattt gctgggataa ggcgggacat ttctttgatc tcccggactt cttatcgtgg    600

aaggcaacag gtgtcacagc acggtctctc tgctccctgg tgtgtaagtg gacatattca    660

gcagagaaag gctgggacga cagtttctgg aaaatgattg gtttggaaga ctttgttgca    720

gataattaca gcaaaatagg aaaccaagtg ctacctcctg gagcttctct tggaaatggg    780

ctcacaccag aggcagcaag agaccttggc cttctccctg ggattgcggt cgcagcttca    840

ctcattgatg cccatgcagg aggactagga gtgattgggg cagatgtgag agggcacggc    900

ctcatctgtg aggggcagcc agtgacgtca cggctggctg tcatctgtgg aacgtcttct    960

tgtcacatgg ggatcagcaa agacccgatt tttgtaccag gcgtctgggg gccttatttc   1020

tcagccatgg tacctgggtt ctggctgaat gaaggtggtc agagcgttac tggaaaattg   1080

atagaccaca tggtacaagg ccatgctgct tttccagaac tacaagtaaa ggccacagcc   1140

aggtaactgc tgtctctgtt ccctctaaaa ttttccttgt gtgactgtat tgagagaatt   1200

cacgttgggc agttgggtga ttttcagatc ctacagacaa tgaaaatgcc tgttagtgct   1260

tgaaagatag tcacctggat gatccagaag atagatgtat taattcttta aatgaggtaa   1320

gagaacttag agaacctaga gataccccaa gaatataccc agggactata gataagaaac   1380

tctgatgtag aagaaggacc atggattctg gagtcaaaac ttcttagttt cacatcccag   1440

ccatactcct taatagatac aggaccttga gctagttact taacctcttt atgcctgtct   1500

cttcatctgt aaaactgaag ataataactg atatggagtg atttctagaa tattttgaag   1560

caagctgagt gcaaaaaaaa tttacgatat actccctttc atgtaaaaag aaagacatag   1620

gaaaatacat gtgtatctgt tcatttttgc aaaagaaata taggaagtgg ccaggtgcgg   1680

tggctcactc ctgtaacccc agcaccttgg gaggccgagg cgggcagatc acgagttcag   1740

agatcgagac cagcctggcc aacatggtga aaccccatct ctactaaaaa tacaaaagtt   1800

agccgggcat ggtgatgtat gcctataatc ccagttactt gggaggttga ggcaggagaa   1860

ttgctcaaac ccgggaggtg gaggttgcag tgagcagaga tcgtgccact gcactccagc   1920

ctgggcaata aagtgagact ccgtctc                                       1947


<210>  1833
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  1833

Met Trp Leu Asp His Arg Ala Val Ser Gln Val Asn Arg Ile Asn Glu 
1               5                   10                  15


Thr Lys His Ser Val Leu Gln Tyr Val Gly Gly Val Met Ser Val Glu 
            20                  25                  30


Met Gln Ala Pro Lys Leu Leu Trp Leu Lys Glu Asn Leu Arg Glu Ile 
        35                  40                  45


Cys Trp Asp Lys Ala Gly His Phe Phe Asp Leu Pro Asp Phe Leu Ser 
    50                  55                  60


Trp Lys Ala Thr Gly Val Thr Ala Arg Ser Leu Cys Ser Leu Val Cys 
65                  70                  75                  80


Lys Trp Thr Tyr Ser Ala Glu Lys Gly Trp Asp Asp Ser Phe Trp Lys 
                85                  90                  95


Met Ile Gly Leu Glu Asp Phe Val Ala Asp Asn Tyr Ser Lys Ile Gly 
            100                 105                 110


Asn Gln Val Leu Pro Pro Gly Ala Ser Leu Gly Asn Gly Leu Thr Pro 
        115                 120                 125


Glu Ala Ala Arg Asp Leu Gly Leu Leu Pro Gly Ile Ala Val Ala Ala 
    130                 135                 140


Ser Leu Ile Asp Ala His Ala Gly Gly Leu Gly Val Ile Gly Ala Asp 
145                 150                 155                 160


Val Arg Gly His Gly Leu Ile Cys Glu Gly Gln Pro Val Thr Ser Arg 
                165                 170                 175


Leu Ala Val Ile Cys Gly Thr Ser Ser Cys His Met Gly Ile Ser Lys 
            180                 185                 190


Asp Pro Ile Phe Val Pro Gly Val Trp Gly Pro Tyr Phe Ser Ala Met 
        195                 200                 205


Val Pro Gly Phe Trp Leu Asn Glu Gly Gly Gln Ser Val Thr Gly Lys 
    210                 215                 220


Leu Ile Asp His Met Val Gln Gly His Ala Ala Phe Pro Glu Leu Gln 
225                 230                 235                 240


Val Lys Ala Thr Ala Arg 
                245


<210>  1834
<211>  1983
<212>  DNA
<213>  Homo sapiens

<400>  1834
agaaagaggc ttctccaacc cggcccggcc cttccttccc ctttcccgca gtcgttgcct     60

cctcctcccc tgcctcctcc tccccttcct cctcctggcc gcttagtctc acacccgccg    120

ggccgttgtt cccgagacgt tgttgagtcc cctgtgtcct cttctgggtg gaggaactgc    180

aatgtctggt ggagaacaga aaccagagag gtactatgtg ggtgtggacg ttggaacagg    240

cagtgtccgt gcagctctgg tggaccagag tggggtcctg ttggcttttg cagaccagcc    300

aattaagaat tgggagcccc agttcaacca ccatgagcag tcctccgagg acatctgggc    360

tgcgtgctgt gttgtcacaa agaaagttgt acaagggatt gatttaaacc aaattcgagg    420

acttgggttt gatgccacgt gttctctggt tgttttggat aagcagtttc acccattacc    480

agtcaaccag gaaggggatt cccatcgaaa cgtcatcatg tggctggacc atcgagcagt    540

cagtcaagtt aacaggatca atgagaccaa gcacagtgtc ctccagtacg tcgggggggt    600

gatgtctgtg gaaatgcagg ccccgaaact tctgtggctg aaagagaact tgagagagat    660

ttgctgggat aaggcgggac atttctttga tctcccggac ttcttatcgt ggaaggcaac    720

aggtgtcaca gcacggtctc tctgctccct ggtgtgtaag tggacatatt cagcagagaa    780

aggctgggac gacagtttct ggaaaatgat tggtttggaa gactttgttg cagataatta    840

cagcaaaata ggaaaccaag tgctacctcc tggagcttct cttggaaatg ggctcacacc    900

agaggcagca agagaccttg gccttctccc tgggattgcg gtcgcagctt cactcattga    960

tgcccatgca ggaggactag gagtgattgg ggcagatgtg agagggcacg gcctcatctg   1020

tgaggggcag ccagtgacgt cacggctggc tgtcatctgt ggaacgtctt cttgtcacat   1080

ggggatcagc aaagacccga tttttgtacc aggcgtctgg gggccttatt tctcagccat   1140

ggtacctggg ttctggctga atgaaggtgg tcagagcgtt actggaaaat tgatagacca   1200

catggtacaa ggccatgctg cttttccaga actacaagta aaggccacag ccagatgcca   1260

gagtatatat gcatatttga acagtcacct ggatctgatt aagaaggctc agcctgtggg   1320

tttccttact gttgatttac atgtttggcc agatttccat ggcaaccggt ctcccttagc   1380

agatctgaca ctaaagggca tggtcaccgg attgaaactg tctcaggacc ttgatgatct   1440

tgccattctc tacctggcca cagttcaagc cattgctttg gggactcgct tcattataga   1500

agccatggag gcagcagggc actcaatcag tactcttttc ctatgtggag gcctcagcaa   1560

gaatcccctt tttgtgcaaa tgcatgcgga cattactggc atgcctgtgg tcctgtcgca   1620

agaggtggag tccgttcttg tgggtgctgc tgttctgggt gcctgtgcct caggggattt   1680

cgcttctgta caggaagcaa tggcaaaaat gagcaaagtt gggaaagttg tgttcccgag   1740

actacaggat aaaaaatact atgataagaa ataccaagta ttcctgaagc tggttgaaca   1800

ccagaaggag tatttggcga tcatgaatga tgactgaaca gggcttgcag gtgctgatgc   1860

cagaagcttc tgtgccattg cattaaagac ttgtcatttg atccatgttc aagacccttg   1920

aggtattgtt tcatcatttc tgtattgtct ttcaataaag aaaacaaaca tgtgcaacca   1980

gaa                                                                 1983


<210>  1835
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  1835

Met Ser Gly Gly Glu Gln Lys Pro Glu Arg Tyr Tyr Val Gly Val Asp 
1               5                   10                  15


Val Gly Thr Gly Ser Val Arg Ala Ala Leu Val Asp Gln Ser Gly Val 
            20                  25                  30


Leu Leu Ala Phe Ala Asp Gln Pro Ile Lys Asn Trp Glu Pro Gln Phe 
        35                  40                  45


Asn His His Glu Gln Ser Ser Glu Asp Ile Trp Ala Ala Cys Cys Val 
    50                  55                  60


Val Thr Lys Lys Val Val Gln Gly Ile Asp Leu Asn Gln Ile Arg Gly 
65                  70                  75                  80


Leu Gly Phe Asp Ala Thr Cys Ser Leu Val Val Leu Asp Lys Gln Phe 
                85                  90                  95


His Pro Leu Pro Val Asn Gln Glu Gly Asp Ser His Arg Asn Val Ile 
            100                 105                 110


Met Trp Leu Asp His Arg Ala Val Ser Gln Val Asn Arg Ile Asn Glu 
        115                 120                 125


Thr Lys His Ser Val Leu Gln Tyr Val Gly Gly Val Met Ser Val Glu 
    130                 135                 140


Met Gln Ala Pro Lys Leu Leu Trp Leu Lys Glu Asn Leu Arg Glu Ile 
145                 150                 155                 160


Cys Trp Asp Lys Ala Gly His Phe Phe Asp Leu Pro Asp Phe Leu Ser 
                165                 170                 175


Trp Lys Ala Thr Gly Val Thr Ala Arg Ser Leu Cys Ser Leu Val Cys 
            180                 185                 190


Lys Trp Thr Tyr Ser Ala Glu Lys Gly Trp Asp Asp Ser Phe Trp Lys 
        195                 200                 205


Met Ile Gly Leu Glu Asp Phe Val Ala Asp Asn Tyr Ser Lys Ile Gly 
    210                 215                 220


Asn Gln Val Leu Pro Pro Gly Ala Ser Leu Gly Asn Gly Leu Thr Pro 
225                 230                 235                 240


Glu Ala Ala Arg Asp Leu Gly Leu Leu Pro Gly Ile Ala Val Ala Ala 
                245                 250                 255


Ser Leu Ile Asp Ala His Ala Gly Gly Leu Gly Val Ile Gly Ala Asp 
            260                 265                 270


Val Arg Gly His Gly Leu Ile Cys Glu Gly Gln Pro Val Thr Ser Arg 
        275                 280                 285


Leu Ala Val Ile Cys Gly Thr Ser Ser Cys His Met Gly Ile Ser Lys 
    290                 295                 300


Asp Pro Ile Phe Val Pro Gly Val Trp Gly Pro Tyr Phe Ser Ala Met 
305                 310                 315                 320


Val Pro Gly Phe Trp Leu Asn Glu Gly Gly Gln Ser Val Thr Gly Lys 
                325                 330                 335


Leu Ile Asp His Met Val Gln Gly His Ala Ala Phe Pro Glu Leu Gln 
            340                 345                 350


Val Lys Ala Thr Ala Arg Cys Gln Ser Ile Tyr Ala Tyr Leu Asn Ser 
        355                 360                 365


His Leu Asp Leu Ile Lys Lys Ala Gln Pro Val Gly Phe Leu Thr Val 
    370                 375                 380


Asp Leu His Val Trp Pro Asp Phe His Gly Asn Arg Ser Pro Leu Ala 
385                 390                 395                 400


Asp Leu Thr Leu Lys Gly Met Val Thr Gly Leu Lys Leu Ser Gln Asp 
                405                 410                 415


Leu Asp Asp Leu Ala Ile Leu Tyr Leu Ala Thr Val Gln Ala Ile Ala 
            420                 425                 430


Leu Gly Thr Arg Phe Ile Ile Glu Ala Met Glu Ala Ala Gly His Ser 
        435                 440                 445


Ile Ser Thr Leu Phe Leu Cys Gly Gly Leu Ser Lys Asn Pro Leu Phe 
    450                 455                 460


Val Gln Met His Ala Asp Ile Thr Gly Met Pro Val Val Leu Ser Gln 
465                 470                 475                 480


Glu Val Glu Ser Val Leu Val Gly Ala Ala Val Leu Gly Ala Cys Ala 
                485                 490                 495


Ser Gly Asp Phe Ala Ser Val Gln Glu Ala Met Ala Lys Met Ser Lys 
            500                 505                 510


Val Gly Lys Val Val Phe Pro Arg Leu Gln Asp Lys Lys Tyr Tyr Asp 
        515                 520                 525


Lys Lys Tyr Gln Val Phe Leu Lys Leu Val Glu His Gln Lys Glu Tyr 
    530                 535                 540


Leu Ala Ile Met Asn Asp Asp 
545                 550


<210>  1836
<211>  471
<212>  DNA
<213>  Homo sapiens

<400>  1836
aaagaggctt ctccaacccg gcccggccct tccttcccct ttcccgcagt cgttgcctcc     60

tcctcccctg cctcctcctc cccttcctcc tcctggccgc ttagtctcac acccgccggg    120

ccgttgttcc cgagacgttg ttgagtcccc tgtgtcctct tctgggagct agataagggc    180

ctggttccac ttctcagtat tcagggaatg gattccctgc ttactccctt ccttcctttg    240

gatgccacaa aatgagcact tgactgaaaa tatgcttata cgcgttttta cagactacgc    300

caagccacag caaatccctg attgcagtat aactaactaa ataaattgca caggacttgt    360

gtacatcaac tcccagcaaa gtccaaagat caaagttgaa agaggatact gaattccttc    420

ccagatttct gggacactgc ttctgtgcac tgtcaccaaa taaatcctgg a             471


<210>  1837
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  1837

Met Pro Gln Asn Glu His Leu Thr Glu Asn Met Leu Ile Arg Val Phe 
1               5                   10                  15


Thr Asp Tyr Ala Lys Pro Gln Gln Ile Pro Asp Cys Ser Ile Thr Asn 
            20                  25                  30


<210>  1838
<211>  2509
<212>  DNA
<213>  Homo sapiens

<400>  1838
agaggcttct ccaacccggc ccggcccttc cttccccttt cccgcagtcg ttgcctcctc     60

ctcccctgcc tcctcctccc cttcctcctc ctggccgctt agtctcacac ccgccgggcc    120

gttgttcccg agacgttgtt gagtcccctg tgtcctcttc tggactacgc caagccacag    180

gtggaggaac tgcaatgtct ggtggagaac agaaaccaga gaggtactat gtgggtgtgg    240

acgttggaac aggcagtgtc cgtgcagctc tggtggacca gagtggggtc ctgttggctt    300

ttgcagacca gccaattaag aattgggagc cccagttcaa ccaccatgag cagtcctccg    360

aggacatctg ggctgcgtgc tgtgttgtca caaagaaagt tgtacaaggg attgatttaa    420

accaaattcg aggacttggg tttgatgcca cgtgttctct ggttgttttg gataagcagt    480

ttcacccatt accagtcaac caggaagggg attcccatcg aaacgtcatc atgtggctgg    540

accatcgagc agtcagtcaa gttaacagga tcaatgagac caagcacagt gtcctccagt    600

acgtcggggg ggtgatgtct gtggaaatgc aggccccgaa acttctgtgg ctgaaagaga    660

acttgagaga gatttgctgg gataaggcgg gacatttctt tgatctcccg gacttcttat    720

cgtggaaggc aacaggtgtc acagcacggt ctctctgctc cctggtgtgt aagtggacat    780

attcagcaga gaaaggctgg gacgacagtt tctggaaaat gattggtttg gaagactttg    840

ttgcagataa ttacagcaaa ataggaaacc aagtgctacc tcctggagct tctcttggaa    900

atgggctcac accagaggca gcaagagacc ttggccttct ccctgggatt gcggtcgcag    960

cttcactcat tgatgcccat gcaggaggac taggagtgat tggggcagat gtgagagggc   1020

acggcctcat ctgtgagggg cagccagtga cgtcacggct ggctgtcatc tgtggaacgt   1080

cttcttgtca catggggatc agcaaagacc cgatttttgt accaggcgtc tgggggcctt   1140

atttctcagc catggtacct gggttctggc tgaatgaagg tggtcagagc gttactggaa   1200

aattgataga ccacatggta caaggccatg ctgcttttcc agaactacaa gtaaaggcca   1260

cagccagatg ccagagtata tatgcatatt tgaacagtca cctggatctg attaagaagg   1320

ctcagcctgt gggtttcctt actgttgatt tacatgtttg gccagatttc catggcaacc   1380

ggtctccctt agcagatctg acactaaagg gcatggtcac cggattgaaa ctgtctcagg   1440

accttgatga tcttgccatt ctctacctgg ccacagttca agccattgct ttggggactc   1500

gcttcattat agaagccatg gaggcagcag ggcactcaat cagtactctt ttcctatgtg   1560

gaggcctcag caagaatccc ctttttgtgc aaatgcatgc ggacattact ggcatgcctg   1620

tggtcctgtc gcaagaggtg gagtccgttc ttgtgggtgc tgctgttctg ggtgcctgtg   1680

cctcagggga tttcgcttct gtacagtggg ggaaatagat agctcagttg tggacgatag   1740

cagcaatggg aagcagtatt tgagaagaaa tcagactctc ttcttccagt cttttgcaag   1800

acagctgtcc ccaaagggat gaatccatta cctttcacca gagttgagtt cgttttccat   1860

ttcatctttc tgcttaaaga gaaagccctt taaaagcgca gcgcatacat tgagtgcgtg   1920

tacttaattt ttaatatgtg tgtgcccaca gccaagagaa cagagaacct taaataataa   1980

tgaaactgaa ttgtacatgt cgtatgtttt atgtggcact gattcctaaa tatgctccta   2040

gcagccaggt attatttaat acatccccat taatcaagct gccaaatcta aatgaaaacc   2100

atgtttaaat atgtttaata agattatagc ttttggttga atatcaaact aacatagcta   2160

catttttcct tccagccagc tctcatttac tgtcttacat ttttactctg aaagcttttg   2220

tactatcaaa ccaatcttga ttataaaaca aattatacca caaactttta gtatcgtgag   2280

cttcagctga gtccctcagt gtaaatgtta ggagaaagaa cagttctgag attttttttc   2340

tggctaaaaa atgatatttt tcttcttctt ggggtgagcc tttgagttta aaaggaaatt   2400

aaaaattcaa ttagagatac taaattgttt gtagcttctg tattaaatga tgtctgcctt   2460

ttgcatagtt attgaaagtg tttcatatta aatgtacttt ttctttttg               2509


<210>  1839
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  1839

Met Ser Gly Gly Glu Gln Lys Pro Glu Arg Tyr Tyr Val Gly Val Asp 
1               5                   10                  15


Val Gly Thr Gly Ser Val Arg Ala Ala Leu Val Asp Gln Ser Gly Val 
            20                  25                  30


Leu Leu Ala Phe Ala Asp Gln Pro Ile Lys Asn Trp Glu Pro Gln Phe 
        35                  40                  45


Asn His His Glu Gln Ser Ser Glu Asp Ile Trp Ala Ala Cys Cys Val 
    50                  55                  60


Val Thr Lys Lys Val Val Gln Gly Ile Asp Leu Asn Gln Ile Arg Gly 
65                  70                  75                  80


Leu Gly Phe Asp Ala Thr Cys Ser Leu Val Val Leu Asp Lys Gln Phe 
                85                  90                  95


His Pro Leu Pro Val Asn Gln Glu Gly Asp Ser His Arg Asn Val Ile 
            100                 105                 110


Met Trp Leu Asp His Arg Ala Val Ser Gln Val Asn Arg Ile Asn Glu 
        115                 120                 125


Thr Lys His Ser Val Leu Gln Tyr Val Gly Gly Val Met Ser Val Glu 
    130                 135                 140


Met Gln Ala Pro Lys Leu Leu Trp Leu Lys Glu Asn Leu Arg Glu Ile 
145                 150                 155                 160


Cys Trp Asp Lys Ala Gly His Phe Phe Asp Leu Pro Asp Phe Leu Ser 
                165                 170                 175


Trp Lys Ala Thr Gly Val Thr Ala Arg Ser Leu Cys Ser Leu Val Cys 
            180                 185                 190


Lys Trp Thr Tyr Ser Ala Glu Lys Gly Trp Asp Asp Ser Phe Trp Lys 
        195                 200                 205


Met Ile Gly Leu Glu Asp Phe Val Ala Asp Asn Tyr Ser Lys Ile Gly 
    210                 215                 220


Asn Gln Val Leu Pro Pro Gly Ala Ser Leu Gly Asn Gly Leu Thr Pro 
225                 230                 235                 240


Glu Ala Ala Arg Asp Leu Gly Leu Leu Pro Gly Ile Ala Val Ala Ala 
                245                 250                 255


Ser Leu Ile Asp Ala His Ala Gly Gly Leu Gly Val Ile Gly Ala Asp 
            260                 265                 270


Val Arg Gly His Gly Leu Ile Cys Glu Gly Gln Pro Val Thr Ser Arg 
        275                 280                 285


Leu Ala Val Ile Cys Gly Thr Ser Ser Cys His Met Gly Ile Ser Lys 
    290                 295                 300


Asp Pro Ile Phe Val Pro Gly Val Trp Gly Pro Tyr Phe Ser Ala Met 
305                 310                 315                 320


Val Pro Gly Phe Trp Leu Asn Glu Gly Gly Gln Ser Val Thr Gly Lys 
                325                 330                 335


Leu Ile Asp His Met Val Gln Gly His Ala Ala Phe Pro Glu Leu Gln 
            340                 345                 350


Val Lys Ala Thr Ala Arg Cys Gln Ser Ile Tyr Ala Tyr Leu Asn Ser 
        355                 360                 365


His Leu Asp Leu Ile Lys Lys Ala Gln Pro Val Gly Phe Leu Thr Val 
    370                 375                 380


Asp Leu His Val Trp Pro Asp Phe His Gly Asn Arg Ser Pro Leu Ala 
385                 390                 395                 400


Asp Leu Thr Leu Lys Gly Met Val Thr Gly Leu Lys Leu Ser Gln Asp 
                405                 410                 415


Leu Asp Asp Leu Ala Ile Leu Tyr Leu Ala Thr Val Gln Ala Ile Ala 
            420                 425                 430


Leu Gly Thr Arg Phe Ile Ile Glu Ala Met Glu Ala Ala Gly His Ser 
        435                 440                 445


Ile Ser Thr Leu Phe Leu Cys Gly Gly Leu Ser Lys Asn Pro Leu Phe 
    450                 455                 460


Val Gln Met His Ala Asp Ile Thr Gly Met Pro Val Val Leu Ser Gln 
465                 470                 475                 480


Glu Val Glu Ser Val Leu Val Gly Ala Ala Val Leu Gly Ala Cys Ala 
                485                 490                 495


Ser Gly Asp Phe Ala Ser Val Gln Trp Gly Lys 
            500                 505


<210>  1840
<211>  1642
<212>  DNA
<213>  Homo sapiens

<400>  1840
atgatcgcat ggagaatgga ttttgttgct ttatctgata ttgtcctcag ctcctcctga     60

atttgccgag atcttacagc agtcagtaag gtggaggaac tgcaatgtct ggtggagaac    120

agaaaccaga gaggtactat gtgggtgtgg acgttggaac aggcagtgtc cgtgcagctc    180

tggtggacca gagtggggtc ctgttggctt ttgcagacca gccaattaag aattgggagc    240

cccagttcaa ccaccatgag cagtcctccg aggacatctg ggctgcgtgc tgtgttgtca    300

caaagaactt gagagagatt tgctgggata aggcgggaca tttctttgat ctcccggact    360

tcttatcgtg gaaggcaaca ggtgtcacag cacggtctct ctgctccctg gtgtgtaagt    420

ggacatattc agcagagaaa ggctgggacg acagtttctg gaaaatgatt ggtttggaag    480

actttgttgc agataattac agcaaaatag gaaaccaagt gctacctcct ggagcttctc    540

ttggaaatgg gctcacacca gaggcagcaa gagaccttgg ccttctccct gggattgcgg    600

tcgcagcttc actcattgat gcccatgcag gaggactagg agtgattggg gcagatgtga    660

gagggcacgg cctcatctgt gaggggcagc cagtgacgtc acggctggct gtcatctgtg    720

gaacgtcttc ttgtcacatg gggatcagca aagacccgat ttttgtacca ggcgtctggg    780

ggccttattt ctcagccatg gtacctgggt tctggctgaa tgaaggtggt cagagcgtta    840

ctggaaaatt gatagaccac atggtacaag gccatgctgc ttttccagaa ctacaagtaa    900

aggccacagc cagatgccag agtatatatg catatttgaa cagtcacctg gatctgatta    960

agaaggctca gcctgtgggt ttccttactg ttgatttaca tgtttggcca gatttccatg   1020

gcaaccggtc tcccttagca gatctgacac taaagggcat ggtcaccgga ttgaaactgt   1080

ctcaggacct tgatgatctt gccattctct acctggccac agttcaagcc attgctttgg   1140

ggactcgctt cattatagaa gccatggagg cagcagggca ctcaatcagt actcttttcc   1200

tatgtggagg cctcagcaag aatccccttt ttgtgcaaat gcatgcggac attactggca   1260

tgcctgtggt cctgtcgcaa gaggtggagt ccgttcttgt gggtgctgct gttctgggtg   1320

cctgtgcctc aggggatttc gcttctgtac aggaagcaat ggcaaaaatg agcaaagttg   1380

ggaaagttgt gttcccgaga ctacaggata aaaaatacta tgataagaaa taccaagtat   1440

tcctgaagct ggttgaacac cagaaggagt atttggcgat catgaatgat gactgaacag   1500

ggcttgcagg tgctgatgcc agaagcttct gtgccattgc attaaagact tgtcatttga   1560

tccatgttca agacccttga ggtattgttt catcatttct gtattgtctt tcaataaaga   1620

aaacaaacat gtgcaaccag aa                                            1642


<210>  1841
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  1841

Met Ser Gly Gly Glu Gln Lys Pro Glu Arg Tyr Tyr Val Gly Val Asp 
1               5                   10                  15


Val Gly Thr Gly Ser Val Arg Ala Ala Leu Val Asp Gln Ser Gly Val 
            20                  25                  30


Leu Leu Ala Phe Ala Asp Gln Pro Ile Lys Asn Trp Glu Pro Gln Phe 
        35                  40                  45


Asn His His Glu Gln Ser Ser Glu Asp Ile Trp Ala Ala Cys Cys Val 
    50                  55                  60


Val Thr Lys Asn Leu Arg Glu Ile Cys Trp Asp Lys Ala Gly His Phe 
65                  70                  75                  80


Phe Asp Leu Pro Asp Phe Leu Ser Trp Lys Ala Thr Gly Val Thr Ala 
                85                  90                  95


Arg Ser Leu Cys Ser Leu Val Cys Lys Trp Thr Tyr Ser Ala Glu Lys 
            100                 105                 110


Gly Trp Asp Asp Ser Phe Trp Lys Met Ile Gly Leu Glu Asp Phe Val 
        115                 120                 125


Ala Asp Asn Tyr Ser Lys Ile Gly Asn Gln Val Leu Pro Pro Gly Ala 
    130                 135                 140


Ser Leu Gly Asn Gly Leu Thr Pro Glu Ala Ala Arg Asp Leu Gly Leu 
145                 150                 155                 160


Leu Pro Gly Ile Ala Val Ala Ala Ser Leu Ile Asp Ala His Ala Gly 
                165                 170                 175


Gly Leu Gly Val Ile Gly Ala Asp Val Arg Gly His Gly Leu Ile Cys 
            180                 185                 190


Glu Gly Gln Pro Val Thr Ser Arg Leu Ala Val Ile Cys Gly Thr Ser 
        195                 200                 205


Ser Cys His Met Gly Ile Ser Lys Asp Pro Ile Phe Val Pro Gly Val 
    210                 215                 220


Trp Gly Pro Tyr Phe Ser Ala Met Val Pro Gly Phe Trp Leu Asn Glu 
225                 230                 235                 240


Gly Gly Gln Ser Val Thr Gly Lys Leu Ile Asp His Met Val Gln Gly 
                245                 250                 255


His Ala Ala Phe Pro Glu Leu Gln Val Lys Ala Thr Ala Arg Cys Gln 
            260                 265                 270


Ser Ile Tyr Ala Tyr Leu Asn Ser His Leu Asp Leu Ile Lys Lys Ala 
        275                 280                 285


Gln Pro Val Gly Phe Leu Thr Val Asp Leu His Val Trp Pro Asp Phe 
    290                 295                 300


His Gly Asn Arg Ser Pro Leu Ala Asp Leu Thr Leu Lys Gly Met Val 
305                 310                 315                 320


Thr Gly Leu Lys Leu Ser Gln Asp Leu Asp Asp Leu Ala Ile Leu Tyr 
                325                 330                 335


Leu Ala Thr Val Gln Ala Ile Ala Leu Gly Thr Arg Phe Ile Ile Glu 
            340                 345                 350


Ala Met Glu Ala Ala Gly His Ser Ile Ser Thr Leu Phe Leu Cys Gly 
        355                 360                 365


Gly Leu Ser Lys Asn Pro Leu Phe Val Gln Met His Ala Asp Ile Thr 
    370                 375                 380


Gly Met Pro Val Val Leu Ser Gln Glu Val Glu Ser Val Leu Val Gly 
385                 390                 395                 400


Ala Ala Val Leu Gly Ala Cys Ala Ser Gly Asp Phe Ala Ser Val Gln 
                405                 410                 415


Glu Ala Met Ala Lys Met Ser Lys Val Gly Lys Val Val Phe Pro Arg 
            420                 425                 430


Leu Gln Asp Lys Lys Tyr Tyr Asp Lys Lys Tyr Gln Val Phe Leu Lys 
        435                 440                 445


Leu Val Glu His Gln Lys Glu Tyr Leu Ala Ile Met Asn Asp Asp 
    450                 455                 460


<210>  1842
<211>  712
<212>  DNA
<213>  Homo sapiens

<400>  1842
gctttcaaga cctgatgctt tgttttgaac aggttgatac atctaggagt gaaatacatc     60

accgctttcc ctgctcccgc cgccattaaa attgtgtttg gcatctgacc accaagatac    120

agatatttcc tagactgttt tgcagctagg tacttagaag tttttctaag ttatttaaac    180

ttctcaccac acaaaatctg gatttgtatc tgtcacgtag taattgcttg ataaatcatt    240

tctctttcct ctggagaaaa atatctgctt tctttaaaat aaatgttcca tccatgcagc    300

taagcagcta aggacacgaa cagccactga tacaggccaa ctcatcagta gattattgag    360

atttcatact aggacctttc attggctgaa caaagacaaa gacagaaatc aaggaaggtc    420

aaagaagcag tcagttttct ggcacccaaa gttgttggag aagggtacag agtcggtaaa    480

taagtcatat gacagacagg cagtattttc ttattttaat aacaagttta aaaatcccac    540

ttcttgtact taccttctgt ctgacgtcat cagtatttta aaatgccaac tgggatcaag    600

ttcaacactg cattactgaa gaatccagat tatctacatt tcaagtgcca aatgaaagaa    660

agaacccaga aaataaaaca atatgatgat aacagtaaaa ttttttaaaa tg            712


<210>  1843
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  1843

Met Pro Thr Gly Ile Lys Phe Asn Thr Ala Leu Leu Lys Asn Pro Asp 
1               5                   10                  15


Tyr Leu His Phe Lys Cys Gln Met Lys Glu Arg Thr Gln Lys Ile Lys 
            20                  25                  30


Gln Tyr Asp Asp Asn Ser Lys Ile Phe 
        35                  40


<210>  1844
<211>  1567
<212>  DNA
<213>  Homo sapiens

<400>  1844
ccttgtcctg cccagatctt gtcccttcta gtactggcct tccccattcc tgggggcccc     60

cgcccctccg acccccgccg accggcgctg gactacaact cccggcgtgc cgcgcgcgtc    120

cggccggctg caccggggct ttgcgcgtgg cggccgccga gctccgcgcg gggcaaacct    180

cccggcgcgg ccatgcgggg agttgctgaa gtaaaggaac cctgcagcct tcccatgcta    240

tctgttgaca tggaaaacaa ggaaaatggc tctgtcggtg taaaaaattc catggaaaat    300

gggagaccac ctgatcctgc agactgggcc gtgatggatg tcgtcaatta tttccgaacc    360

gtgggatttg aggagcaagc tagtgctttt caggaacagg aaattgatgg aaaatccctg    420

ctattgatga caagaaatga tgtgttgaca ggacttcagt taaaattggg gcctgctctg    480

aaaatctacg aatatcatgt aaaacctctg cagacaaagc atttaaagaa caactcttca    540

tagtacagtc aaattggggt cttcgacctc aaaaaataca taatgacata atttagtttc    600

atgtaatgaa actttgtaaa cagaatacat acatgtgtat atgtaaagaa tttcaatcaa    660

atgaaacgtt atcctattgg atagactagg caattcatca gctcacctga aatcagccag    720

gaggagcaag gacaagatgc gcacagggtg gttttcctca tggattttgt caaatagatg    780

atctttgaca cgattagaca ctcctcccca caaaggcttt gaaatcataa ggattttcct    840

catctcttta tagctttccc aaaatctttt aaaaaagaat ttaattaaat gacagtcttt    900

tggttacaga cttaggatga gtaaaaacaa gaaaatttgg ggagggggag aaagaagaaa    960

gggattgctg tctcccttga attcctctgt tccttagagc ttgtgttact tggacggaat   1020

tgccaacacc cttttttata gagggttctc cacttgacct tattaaggtt ttattgggat   1080

atgctgcagt gtttgaaatg aacatgcatc atggcccctt caggagcaga atcatagctc   1140

tgaaaagaga agctccgttg tgtactgagg atatccatcc atattcagct agctttcaaa   1200

tggggtaacg atattttctg catagatttt cttttaaatt ggttctttgt ttctgaagaa   1260

agaatttttt ttaacttcat ggttttattt ataataattt gtttctgaag aaatttgccg   1320

agagttacag gtcaaaaagc cttgttacta gtacagaata tttttatata tattccttca   1380

tgatggtgta atttttttta attgtcctat gctttgttcg gttcctgggt taagtacttg   1440

tttttaagag cttggaaaaa gtgggcttgc tacatctctg ttcaaagaga catttgttca   1500

atctctgtgt gtcaacgcct tgttgaattg gtgctttgtg gttgcaataa agcattgctt   1560

cagttta                                                             1567


<210>  1845
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  1845

Met Arg Gly Val Ala Glu Val Lys Glu Pro Cys Ser Leu Pro Met Leu 
1               5                   10                  15


Ser Val Asp Met Glu Asn Lys Glu Asn Gly Ser Val Gly Val Lys Asn 
            20                  25                  30


Ser Met Glu Asn Gly Arg Pro Pro Asp Pro Ala Asp Trp Ala Val Met 
        35                  40                  45


Asp Val Val Asn Tyr Phe Arg Thr Val Gly Phe Glu Glu Gln Ala Ser 
    50                  55                  60


Ala Phe Gln Glu Gln Glu Ile Asp Gly Lys Ser Leu Leu Leu Met Thr 
65                  70                  75                  80


Arg Asn Asp Val Leu Thr Gly Leu Gln Leu Lys Leu Gly Pro Ala Leu 
                85                  90                  95


Lys Ile Tyr Glu Tyr His Val Lys Pro Leu Gln Thr Lys His Leu Lys 
            100                 105                 110


Asn Asn Ser Ser 
        115


<210>  1846
<211>  1452
<212>  DNA
<213>  Homo sapiens

<400>  1846
cacactcaca tactttatgc tacatactac acacacaact ttttatcagc agaggattga     60

tggcaaacag tttgttggag ggagtgtttg ctgaagtaaa ggaaccctgc agccttccca    120

tgctatctgt tgacatggaa aacaaggaaa atggctctgt cggtgtaaaa aattccatgg    180

aaaatgggag accacctgat cctgcagact gggccgtgat ggatgtcgtc aattatttcc    240

gaaccgtggg atttgaggag caagctagtg cttttcagga acaggaaatt gatggaaaat    300

ccctgctatt gatgacaaga aatgatgtgt tgacaggact tcagttaaaa ttggggcctg    360

ctctgaaaat ctacgaatat catgtaaaac ctctgcagac aaagcattta aagaacaact    420

cttcatagta cagtcaaatt ggggtcttcg acctcaaaaa atacataatg acataattta    480

gtttcatgta atgaaacttt gtaaacagaa tacatacatg tgtatatgta aagaatttca    540

atcaaatgaa acgttatcct attggataga ctaggcaatt catcagctca cctgaaatca    600

gccaggagga gcaaggacaa gatgcgcaca gggtggtttt cctcatggat tttgtcaaat    660

agatgatctt tgacacgatt agacactcct ccccacaaag gctttgaaat cataaggatt    720

ttcctcatct ctttatagct ttcccaaaat cttttaaaaa agaatttaat taaatgacag    780

tcttttggtt acagacttag gatgagtaaa aacaagaaaa tttggggagg gggagaaaga    840

agaaagggat tgctgtctcc cttgaattcc tctgttcctt agagcttgtg ttacttggac    900

ggaattgcca acaccctttt ttatagaggg ttctccactt gaccttatta aggttttatt    960

gggatatgct gcagtgtttg aaatgaacat gcatcatggc cccttcagga gcagaatcat   1020

agctctgaaa agagaagctc cgttgtgtac tgaggatatc catccatatt cagctagctt   1080

tcaaatgggg taacgatatt ttctgcatag attttctttt aaattggttc tttgtttctg   1140

aagaaagaat tttttttaac ttcatggttt tatttataat aatttgtttc tgaagaaatt   1200

tgccgagagt tacaggtcaa aaagccttgt tactagtaca gaatattttt atatatattc   1260

cttcatgatg gtgtaatttt ttttaattgt cctatgcttt gttcggttcc tgggttaagt   1320

acttgttttt aagagcttgg aaaaagtggg cttgctacat ctctgttcaa agagacattt   1380

gttcaatctc tgtgtgtcaa cgccttgttg aattggtgct ttgtggttgc aataaagcat   1440

tgcttcagtt ta                                                       1452


<210>  1847
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  1847

Met Ala Asn Ser Leu Leu Glu Gly Val Phe Ala Glu Val Lys Glu Pro 
1               5                   10                  15


Cys Ser Leu Pro Met Leu Ser Val Asp Met Glu Asn Lys Glu Asn Gly 
            20                  25                  30


Ser Val Gly Val Lys Asn Ser Met Glu Asn Gly Arg Pro Pro Asp Pro 
        35                  40                  45


Ala Asp Trp Ala Val Met Asp Val Val Asn Tyr Phe Arg Thr Val Gly 
    50                  55                  60


Phe Glu Glu Gln Ala Ser Ala Phe Gln Glu Gln Glu Ile Asp Gly Lys 
65                  70                  75                  80


Ser Leu Leu Leu Met Thr Arg Asn Asp Val Leu Thr Gly Leu Gln Leu 
                85                  90                  95


Lys Leu Gly Pro Ala Leu Lys Ile Tyr Glu Tyr His Val Lys Pro Leu 
            100                 105                 110


Gln Thr Lys His Leu Lys Asn Asn Ser Ser 
        115                 120


<210>  1848
<211>  1506
<212>  DNA
<213>  Homo sapiens

<400>  1848
agcctggttt tatttcactg tgtcaaattg tacctcctta ttgaattcct ttgccagcct     60

actttgtgaa agaaaacatt ggggtttctt tggctgttct tgataagcct ataaaaaatg    120

atatttttta gttgcttata gttgctgaag taaaggaacc ctgcagcctt cccatgctat    180

ctgttgacat ggaaaacaag gaaaatggct ctgtcggtgt aaaaaattcc atggaaaatg    240

ggagaccacc tgatcctgca gactgggccg tgatggatgt cgtcaattat ttccgaaccg    300

tgggatttga ggagcaagct agtgcttttc aggaacagga aattgatgga aaatccctgc    360

tattgatgac aagaaatgat gtgttgacag gacttcagtt aaaattgggg cctgctctga    420

aaatctacga atatcatgta aaacctctgc agacaaagca tttaaagaac aactcttcat    480

agtacagtca aattggggtc ttcgacctca aaaaatacat aatgacataa tttagtttca    540

tgtaatgaaa ctttgtaaac agaatacata catgtgtata tgtaaagaat ttcaatcaaa    600

tgaaacgtta tcctattgga tagactaggc aattcatcag ctcacctgaa atcagccagg    660

aggagcaagg acaagatgcg cacagggtgg ttttcctcat ggattttgtc aaatagatga    720

tctttgacac gattagacac tcctccccac aaaggctttg aaatcataag gattttcctc    780

atctctttat agctttccca aaatctttta aaaaagaatt taattaaatg acagtctttt    840

ggttacagac ttaggatgag taaaaacaag aaaatttggg gagggggaga aagaagaaag    900

ggattgctgt ctcccttgaa ttcctctgtt ccttagagct tgtgttactt ggacggaatt    960

gccaacaccc ttttttatag agggttctcc acttgacctt attaaggttt tattgggata   1020

tgctgcagtg tttgaaatga acatgcatca tggccccttc aggagcagaa tcatagctct   1080

gaaaagagaa gctccgttgt gtactgagga tatccatcca tattcagcta gctttcaaat   1140

ggggtaacga tattttctgc atagattttc ttttaaattg gttctttgtt tctgaagaaa   1200

gaattttttt taacttcatg gttttattta taataatttg tttctgaaga aatttgccga   1260

gagttacagg tcaaaaagcc ttgttactag tacagaatat ttttatatat attccttcat   1320

gatggtgtaa ttttttttaa ttgtcctatg ctttgttcgg ttcctgggtt aagtacttgt   1380

ttttaagagc ttggaaaaag tgggcttgct acatctctgt tcaaagagac atttgttcaa   1440

tctctgtgtg tcaacgcctt gttgaattgg tgctttgtgg ttgcaataaa gcattgcttc   1500

agttta                                                              1506


<210>  1849
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  1849

Met Leu Ser Val Asp Met Glu Asn Lys Glu Asn Gly Ser Val Gly Val 
1               5                   10                  15


Lys Asn Ser Met Glu Asn Gly Arg Pro Pro Asp Pro Ala Asp Trp Ala 
            20                  25                  30


Val Met Asp Val Val Asn Tyr Phe Arg Thr Val Gly Phe Glu Glu Gln 
        35                  40                  45


Ala Ser Ala Phe Gln Glu Gln Glu Ile Asp Gly Lys Ser Leu Leu Leu 
    50                  55                  60


Met Thr Arg Asn Asp Val Leu Thr Gly Leu Gln Leu Lys Leu Gly Pro 
65                  70                  75                  80


Ala Leu Lys Ile Tyr Glu Tyr His Val Lys Pro Leu Gln Thr Lys His 
                85                  90                  95


Leu Lys Asn Asn Ser Ser 
            100


<210>  1850
<211>  1660
<212>  DNA
<213>  Homo sapiens

<400>  1850
tactttgtga aagaaaacat tggggtttct ttggctgttc ttgataagcc tataaaaaat     60

gatatttttt agttgcttat aggtaggttt tctttttact cttccacaga aaagaaaata    120

atagtaataa taataagaca atgtagtgtg gtgttgcaga gtatcattgt gagtgttttg    180

ttttgttttc tgagatgctt agaaaatggt gaatgtgtaa cagtttccaa ctgaagtgaa    240

atcatattct gttagcatgg agcagcagca ctatcttcct gtctactctc taacgttgct    300

gaagtaaagg aaccctgcag ccttcccatg ctatctgttg acatggaaaa caaggaaaat    360

ggctctgtcg gtgtaaaaaa ttccatggaa aatgggagac cacctgatcc tgcagactgg    420

gccgtgatgg atgtcgtcaa ttatttccga accgtgggat ttgaggagca agctagtgct    480

tttcaggaac aggaaattga tggaaaatcc ctgctattga tgacaagaaa tgatgtgttg    540

acaggacttc agttaaaatt ggggcctgct ctgaaaatct acgaatatca tgtaaaacct    600

ctgcagacaa agcatttaaa gaacaactct tcatagtaca gtcaaattgg ggtcttcgac    660

ctcaaaaaat acataatgac ataatttagt ttcatgtaat gaaactttgt aaacagaata    720

catacatgtg tatatgtaaa gaatttcaat caaatgaaac gttatcctat tggatagact    780

aggcaattca tcagctcacc tgaaatcagc caggaggagc aaggacaaga tgcgcacagg    840

gtggttttcc tcatggattt tgtcaaatag atgatctttg acacgattag acactcctcc    900

ccacaaaggc tttgaaatca taaggatttt cctcatctct ttatagcttt cccaaaatct    960

tttaaaaaag aatttaatta aatgacagtc ttttggttac agacttagga tgagtaaaaa   1020

caagaaaatt tggggagggg gagaaagaag aaagggattg ctgtctccct tgaattcctc   1080

tgttccttag agcttgtgtt acttggacgg aattgccaac accctttttt atagagggtt   1140

ctccacttga ccttattaag gttttattgg gatatgctgc agtgtttgaa atgaacatgc   1200

atcatggccc cttcaggagc agaatcatag ctctgaaaag agaagctccg ttgtgtactg   1260

aggatatcca tccatattca gctagctttc aaatggggta acgatatttt ctgcatagat   1320

tttcttttaa attggttctt tgtttctgaa gaaagaattt tttttaactt catggtttta   1380

tttataataa tttgtttctg aagaaatttg ccgagagtta caggtcaaaa agccttgtta   1440

ctagtacaga atatttttat atatattcct tcatgatggt gtaatttttt ttaattgtcc   1500

tatgctttgt tcggttcctg ggttaagtac ttgtttttaa gagcttggaa aaagtgggct   1560

tgctacatct ctgttcaaag agacatttgt tcaatctctg tgtgtcaacg ccttgttgaa   1620

ttggtgcttt gtggttgcaa taaagcattg cttcagttta                         1660


<210>  1851
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  1851

Met Leu Ser Val Asp Met Glu Asn Lys Glu Asn Gly Ser Val Gly Val 
1               5                   10                  15


Lys Asn Ser Met Glu Asn Gly Arg Pro Pro Asp Pro Ala Asp Trp Ala 
            20                  25                  30


Val Met Asp Val Val Asn Tyr Phe Arg Thr Val Gly Phe Glu Glu Gln 
        35                  40                  45


Ala Ser Ala Phe Gln Glu Gln Glu Ile Asp Gly Lys Ser Leu Leu Leu 
    50                  55                  60


Met Thr Arg Asn Asp Val Leu Thr Gly Leu Gln Leu Lys Leu Gly Pro 
65                  70                  75                  80


Ala Leu Lys Ile Tyr Glu Tyr His Val Lys Pro Leu Gln Thr Lys His 
                85                  90                  95


Leu Lys Asn Asn Ser Ser 
            100


<210>  1852
<211>  1405
<212>  DNA
<213>  Homo sapiens

<400>  1852
ctcacagacg ggtttttgag gctttcgttg agaatgtgag ttgctgaagt aaaggaaccc     60

tgcagccttc ccatgctatc tgttgacatg gaaaacaagg aaaatggctc tgtcggtgta    120

aaaaattcca tggaaaatgg gagaccacct gatcctgcag actgggccgt gatggatgtc    180

gtcaattatt tccgaaccgt gggatttgag gagcaagcta gtgcttttca ggaacaggaa    240

attgatggaa aatccctgct attgatgaca agaaatgatg tgttgacagg acttcagtta    300

aaattggggc ctgctctgaa aatctacgaa tatcatgtaa aacctctgca gacaaagcat    360

ttaaagaaca actcttcata gtacagtcaa attggggtct tcgacctcaa aaaatacata    420

atgacataat ttagtttcat gtaatgaaac tttgtaaaca gaatacatac atgtgtatat    480

gtaaagaatt tcaatcaaat gaaacgttat cctattggat agactaggca attcatcagc    540

tcacctgaaa tcagccagga ggagcaagga caagatgcgc acagggtggt tttcctcatg    600

gattttgtca aatagatgat ctttgacacg attagacact cctccccaca aaggctttga    660

aatcataagg attttcctca tctctttata gctttcccaa aatcttttaa aaaagaattt    720

aattaaatga cagtcttttg gttacagact taggatgagt aaaaacaaga aaatttgggg    780

agggggagaa agaagaaagg gattgctgtc tcccttgaat tcctctgttc cttagagctt    840

gtgttacttg gacggaattg ccaacaccct tttttataga gggttctcca cttgacctta    900

ttaaggtttt attgggatat gctgcagtgt ttgaaatgaa catgcatcat ggccccttca    960

ggagcagaat catagctctg aaaagagaag ctccgttgtg tactgaggat atccatccat   1020

attcagctag ctttcaaatg gggtaacgat attttctgca tagattttct tttaaattgg   1080

ttctttgttt ctgaagaaag aatttttttt aacttcatgg ttttatttat aataatttgt   1140

ttctgaagaa atttgccgag agttacaggt caaaaagcct tgttactagt acagaatatt   1200

tttatatata ttccttcatg atggtgtaat tttttttaat tgtcctatgc tttgttcggt   1260

tcctgggtta agtacttgtt tttaagagct tggaaaaagt gggcttgcta catctctgtt   1320

caaagagaca tttgttcaat ctctgtgtgt caacgccttg ttgaattggt gctttgtggt   1380

tgcaataaag cattgcttca gttta                                         1405


<210>  1853
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  1853

Met Leu Ser Val Asp Met Glu Asn Lys Glu Asn Gly Ser Val Gly Val 
1               5                   10                  15


Lys Asn Ser Met Glu Asn Gly Arg Pro Pro Asp Pro Ala Asp Trp Ala 
            20                  25                  30


Val Met Asp Val Val Asn Tyr Phe Arg Thr Val Gly Phe Glu Glu Gln 
        35                  40                  45


Ala Ser Ala Phe Gln Glu Gln Glu Ile Asp Gly Lys Ser Leu Leu Leu 
    50                  55                  60


Met Thr Arg Asn Asp Val Leu Thr Gly Leu Gln Leu Lys Leu Gly Pro 
65                  70                  75                  80


Ala Leu Lys Ile Tyr Glu Tyr His Val Lys Pro Leu Gln Thr Lys His 
                85                  90                  95


Leu Lys Asn Asn Ser Ser 
            100


<210>  1854
<211>  1433
<212>  DNA
<213>  Homo sapiens

<400>  1854
ctttaggttt aatcacatct ctccaatcgc cgagggaact ggagatttaa acaaacatac     60

gtgaactgtt gctgaagtaa aggaaccctg cagccttccc atgctatctg ttgacatgga    120

aaacaaggaa aatggctctg tcggtgtaaa aaattccatg gaaaatggga gaccacctga    180

tcctgcagac tgggccgtga tggatgtcgt caattatttc cgaaccgtgg gatttgagga    240

gcaagctagt gcttttcagg aacaggaaat tgatggaaaa tccctgctat tgatgacaag    300

aaatgatgtg ttgacaggac ttcagttaaa attggggcct gctctgaaaa tctacgaata    360

tcatgtaaaa cctctgcaga caaagcattt aaagaacaac tcttcatagt acagtcaaat    420

tggggtcttc gacctcaaaa aatacataat gacataattt agtttcatgt aatgaaactt    480

tgtaaacaga atacatacat gtgtatatgt aaagaatttc aatcaaatga aacgttatcc    540

tattggatag actaggcaat tcatcagctc acctgaaatc agccaggagg agcaaggaca    600

agatgcgcac agggtggttt tcctcatgga ttttgtcaaa tagatgatct ttgacacgat    660

tagacactcc tccccacaaa ggctttgaaa tcataaggat tttcctcatc tctttatagc    720

tttcccaaaa tcttttaaaa aagaatttaa ttaaatgaca gtcttttggt tacagactta    780

ggatgagtaa aaacaagaaa atttggggag ggggagaaag aagaaaggga ttgctgtctc    840

ccttgaattc ctctgttcct tagagcttgt gttacttgga cggaattgcc aacacccttt    900

tttatagagg gttctccact tgaccttatt aaggttttat tgggatatgc tgcagtgttt    960

gaaatgaaca tgcatcatgg ccccttcagg agcagaatca tagctctgaa aagagaagct   1020

ccgttgtgta ctgaggatat ccatccatat tcagctagct ttcaaatggg gtaacgatat   1080

tttctgcata gattttcttt taaattggtt ctttgtttct gaagaaagaa ttttttttaa   1140

cttcatggtt ttatttataa taatttgttt ctgaagaaat ttgccgagag ttacaggtca   1200

aaaagccttg ttactagtac agaatatttt tatatatatt ccttcatgat ggtgtaattt   1260

tttttaattg tcctatgctt tgttcggttc ctgggttaag tacttgtttt taagagcttg   1320

gaaaaagtgg gcttgctaca tctctgttca aagagacatt tgttcaatct ctgtgtgtca   1380

acgccttgtt gaattggtgc tttgtggttg caataaagca ttgcttcagt tta          1433


<210>  1855
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  1855

Met Leu Ser Val Asp Met Glu Asn Lys Glu Asn Gly Ser Val Gly Val 
1               5                   10                  15


Lys Asn Ser Met Glu Asn Gly Arg Pro Pro Asp Pro Ala Asp Trp Ala 
            20                  25                  30


Val Met Asp Val Val Asn Tyr Phe Arg Thr Val Gly Phe Glu Glu Gln 
        35                  40                  45


Ala Ser Ala Phe Gln Glu Gln Glu Ile Asp Gly Lys Ser Leu Leu Leu 
    50                  55                  60


Met Thr Arg Asn Asp Val Leu Thr Gly Leu Gln Leu Lys Leu Gly Pro 
65                  70                  75                  80


Ala Leu Lys Ile Tyr Glu Tyr His Val Lys Pro Leu Gln Thr Lys His 
                85                  90                  95


Leu Lys Asn Asn Ser Ser 
            100


<210>  1856
<211>  362
<212>  DNA
<213>  Homo sapiens

<400>  1856
gtgatggatg tcgtcaatta tttccgaacc gtgggatttg aggagcaagc tagtgctttt     60

caggaacagg ataaagttac tgacagagat aaatacctag aatgcacacc aatcgagagc    120

tggagtggtc aaatcaaagg gctgctgcta tgataaggcc tacttctgcc tgcctaccct    180

cagaaacagg atctcactat gttgcccagg ctggagcata gtggttattc acaggcgtga    240

tcccactact gatcagtaca ggagtttcat ctctttttga taaagaagac tgaggatccc    300

acacaggtgc acactgtttt gtgctataga tgtacaacta ataaaacaaa tccttgtcaa    360

ta                                                                   362


<210>  1857
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  1857

Met Asp Val Val Asn Tyr Phe Arg Thr Val Gly Phe Glu Glu Gln Ala 
1               5                   10                  15


Ser Ala Phe Gln Glu Gln Asp Lys Val Thr Asp Arg Asp Lys Tyr Leu 
            20                  25                  30


Glu Cys Thr Pro Ile Glu Ser Trp Ser Gly Gln Ile Lys Gly Leu Leu 
        35                  40                  45


Leu 



<210>  1858
<211>  1461
<212>  DNA
<213>  Homo sapiens

<400>  1858
atggtgaatt actacaaagt actaggtgtg cctcaaaatg cttcctcccc tgatattaag     60

aaggcttatc accagttggc tctgcaggta cacccagaca agaacccagg gaacaaagag    120

gcatctgagg agaaattcaa acaagtagca agaggcctat gaggtcttgt ctgatgccag    180

gaaatgaaat gagtatgaca agtccagaag gaaccgaacc aaaagggaaa cagaggagat    240

ggcagagaca aaaaacattt ggaggaggaa ctatgcattc tcaggattct caggaaattg    300

atggaaaatc cctgctattg atgacaagaa atgatgtgtt gacaggactt cagttaaaat    360

tggggcctgc tctgaaaatc tacgaatatc atgtaaaacc tctgcagaca aagcatttaa    420

agaacaactc ttcatagtac agtcaaattg gggtcttcga cctcaaaaaa tacataatga    480

cataatttag tttcatgtaa tgaaactttg taaacagaat acatacatgt gtatatgtaa    540

agaatttcaa tcaaatgaaa cgttatccta ttggatagac taggcaattc atcagctcac    600

ctgaaatcag ccaggaggag caaggacaag atgcgcacag ggtggttttc ctcatggatt    660

ttgtcaaata gatgatcttt gacacgatta gacactcctc cccacaaagg ctttgaaatc    720

ataaggattt tcctcatctc tttatagctt tcccaaaatc ttttaaaaaa gaatttaatt    780

aaatgacagt cttttggtta cagacttagg atgagtaaaa acaagaaaat ttggggaggg    840

ggagaaagaa gaaagggatt gctgtctccc ttgaattcct ctgttcctta gagcttgtgt    900

tacttggacg gaattgccaa cacccttttt tatagagggt tctccacttg accttattaa    960

ggttttattg ggatatgctg cagtgtttga aatgaacatg catcatggcc ccttcaggag   1020

cagaatcata gctctgaaaa gagaagctcc gttgtgtact gaggatatcc atccatattc   1080

agctagcttt caaatggggt aacgatattt tctgcataga ttttctttta aattggttct   1140

ttgtttctga agaaagaatt ttttttaact tcatggtttt atttataata atttgtttct   1200

gaagaaattt gccgagagtt acaggtcaaa aagccttgtt actagtacag aatattttta   1260

tatatattcc ttcatgatgg tgtaattttt tttaattgtc ctatgctttg ttcggttcct   1320

gggttaagta cttgttttta agagcttgga aaaagtgggc ttgctacatc tctgttcaaa   1380

gagacatttg ttcaatctct gtgtgtcaac gccttgttga attggtgctt tgtggttgca   1440

ataaagcatt gcttcagttt a                                             1461


<210>  1859
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  1859

Met Arg Ser Cys Leu Met Pro Gly Asn Glu Met Ser Met Thr Ser Pro 
1               5                   10                  15


Glu Gly Thr Glu Pro Lys Gly Lys Gln Arg Arg Trp Gln Arg Gln Lys 
            20                  25                  30


Thr Phe Gly Gly Gly Thr Met His Ser Gln Asp Ser Gln Glu Ile Asp 
        35                  40                  45


Gly Lys Ser Leu Leu Leu Met Thr Arg Asn Asp Val Leu Thr Gly Leu 
    50                  55                  60


Gln Leu Lys Leu Gly Pro Ala Leu Lys Ile Tyr Glu Tyr His Val Lys 
65                  70                  75                  80


Pro Leu Gln Thr Lys His Leu Lys Asn Asn Ser Ser 
                85                  90


<210>  1860
<211>  1764
<212>  DNA
<213>  Homo sapiens

<400>  1860
atggtgaatt actacaaagt actaggtgtg cctcaaaatg cttcctcccc tgatattaag     60

aaggcttatc accagttggc tctgcaggta cacccagaca agaacccagg gaacaaagag    120

gcatctgagg agaaattcaa acaagtagca agaggcctat gaggtcttgt ctgatgccag    180

gaaatgaaat gagtatgaca agtccagaag gaaccgaacc aaaagggaaa cagaggagat    240

ggcagagaca aaaaacattt ggaggaggaa ctatgcattc tcaggattct caggtgatga    300

tttttccctt ggccttgtgg gtaaagccag gagattccac tcctccatct ttgatgtggc    360

tcccatattg gacacaggat tttccacttt tttatctctg ggctccagag caagtacctc    420

tacctctgag acatttgaac cctttgtaag cagcagactg agaaacttca gactggtcac    480

catttgtagc cagacagtaa atggcaagag agttgttaca aagaaagtgc tagaagatgt    540

gagggggaag aatgaagcag aaaaagactg tttcatgaga ttcctccaca tcattggaaa    600

ttgatggaaa atccctgcta ttgatgacaa gaaatgatgt gttgacagga cttcagttaa    660

aattggggcc tgctctgaaa atctacgaat atcatgtaaa acctctgcag acaaagcatt    720

taaagaacaa ctcttcatag tacagtcaaa ttggggtctt cgacctcaaa aaatacataa    780

tgacataatt tagtttcatg taatgaaact ttgtaaacag aatacataca tgtgtatatg    840

taaagaattt caatcaaatg aaacgttatc ctattggata gactaggcaa ttcatcagct    900

cacctgaaat cagccaggag gagcaaggac aagatgcgca cagggtggtt ttcctcatgg    960

attttgtcaa atagatgatc tttgacacga ttagacactc ctccccacaa aggctttgaa   1020

atcataagga ttttcctcat ctctttatag ctttcccaaa atcttttaaa aaagaattta   1080

attaaatgac agtcttttgg ttacagactt aggatgagta aaaacaagaa aatttgggga   1140

gggggagaaa gaagaaaggg attgctgtct cccttgaatt cctctgttcc ttagagcttg   1200

tgttacttgg acggaattgc caacaccctt ttttatagag ggttctccac ttgaccttat   1260

taaggtttta ttgggatatg ctgcagtgtt tgaaatgaac atgcatcatg gccccttcag   1320

gagcagaatc atagctctga aaagagaagc tccgttgtgt actgaggata tccatccata   1380

ttcagctagc tttcaaatgg ggtaacgata ttttctgcat agattttctt ttaaattggt   1440

tctttgtttc tgaagaaaga atttttttta acttcatggt tttatttata ataatttgtt   1500

tctgaagaaa tttgccgaga gttacaggtc aaaaagcctt gttactagta cagaatattt   1560

ttatatatat tccttcatga tggtgtaatt ttttttaatt gtcctatgct ttgttcggtt   1620

cctgggttaa gtacttgttt ttaagagctt ggaaaaagtg ggcttgctac atctctgttc   1680

aaagagacat ttgttcaatc tctgtgtgtc aacgccttgt tgaattggtg ctttgtggtt   1740

gcaataaagc attgcttcag ttta                                          1764


<210>  1861
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  1861

Met Ala Glu Thr Lys Asn Ile Trp Arg Arg Asn Tyr Ala Phe Ser Gly 
1               5                   10                  15


Phe Ser Gly Asp Asp Phe Ser Leu Gly Leu Val Gly Lys Ala Arg Arg 
            20                  25                  30


Phe His Ser Ser Ile Phe Asp Val Ala Pro Ile Leu Asp Thr Gly Phe 
        35                  40                  45


Ser Thr Phe Leu Ser Leu Gly Ser Arg Ala Ser Thr Ser Thr Ser Glu 
    50                  55                  60


Thr Phe Glu Pro Phe Val Ser Ser Arg Leu Arg Asn Phe Arg Leu Val 
65                  70                  75                  80


Thr Ile Cys Ser Gln Thr Val Asn Gly Lys Arg Val Val Thr Lys Lys 
                85                  90                  95


Val Leu Glu Asp Val Arg Gly Lys Asn Glu Ala Glu Lys Asp Cys Phe 
            100                 105                 110


Met Arg Phe Leu His Ile Ile Gly Asn 
        115                 120


<210>  1862
<211>  531
<212>  DNA
<213>  Homo sapiens

<400>  1862
aagcagagca gcaagatggg acaccattcg ggaccttgtc atggagaaat ctgctgggcc     60

ctatgacaaa ggtgaatact tgacctctgt gcagaagacc ctctgtgata tccaggtgct    120

ctccctgagc cgagttcctg cgatagaaga tatggaaatc agcctgccaa acattcacta    180

cttcaacata gacatgtcca aaatgggtct gatcaacaag gaagaggtaa gaggcccaca    240

tagaaaagct gtcattggcc tccgggtcag gcaagagatg ggaggtgttc agagcagcaa    300

accctacaag atgttggagg ccattcacaa gcaagcgcct gcttggaaaa taacgtggga    360

taagaacaat gaaataattt gatgaggaaa gtgttgtgct acattgaata ctcacgtcac    420

aaaatgtgct tctacattat gtaacttaca tggtcaaatg actggtacat tttattcctg    480

tgctaatttg tcaattctgt tccaagagga aagagtctaa catgactttt c             531


<210>  1863
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  1863

Met Glu Lys Ser Ala Gly Pro Tyr Asp Lys Gly Glu Tyr Leu Thr Ser 
1               5                   10                  15


Val Gln Lys Thr Leu Cys Asp Ile Gln Val Leu Ser Leu Ser Arg Val 
            20                  25                  30


Pro Ala Ile Glu Asp Met Glu Ile Ser Leu Pro Asn Ile His Tyr Phe 
        35                  40                  45


Asn Ile Asp Met Ser Lys Met Gly Leu Ile Asn Lys Glu Glu Val Arg 
    50                  55                  60


Gly Pro His Arg Lys Ala Val Ile Gly Leu Arg Val Arg Gln Glu Met 
65                  70                  75                  80


Gly Gly Val Gln Ser Ser Lys Pro Tyr Lys Met Leu Glu Ala Ile His 
                85                  90                  95


Lys Gln Ala Pro Ala Trp Lys Ile Thr Trp Asp Lys Asn Asn Glu Ile 
            100                 105                 110


Ile 



<210>  1864
<211>  661
<212>  DNA
<213>  Homo sapiens

<400>  1864
tcttacagca ttggacaatg actcatggat gaggaaattg actcatctct caactattgc     60

cagaataata aggcattacc atgcttgaag taactttagt ggaggacata cacattttcc    120

tgtttagtct tgctgccatt agacaatcca tatggaaaaa ttactggtac agtcaagagg    180

aagttgtctt caagactgtg acattgtggc caccaatagg agtccactct cagctgagga    240

attccttaag tcatttgtga tgctggagat gatagcatgt agccatgcaa aatttcacac    300

tagtatattg atttatagtg ttcactttcc tccaatatga aacagtttat ttcttctaca    360

cctagctcag caaggcattc tgtggattac cttattagta attataacag gctttatggc    420

tataatttac tttaaaaatg ctgagcagta ttagaacagt tataaatcaa tatttctttt    480

tggttatctt atgccttcct atcttggaga agctttagaa tcaattcatt aagaaaataa    540

tcatgaatta atgagtgtgt cacatcaatt aatttgtgca caggtttaag aaacaaatat    600

tgttttcatc ctactgatgc ttctaagtaa tgcagaaaat gaaataaaat tatattgaaa    660

a                                                                    661


<210>  1865
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  1865

Met Leu Glu Val Thr Leu Val Glu Asp Ile His Ile Phe Leu Phe Ser 
1               5                   10                  15


Leu Ala Ala Ile Arg Gln Ser Ile Trp Lys Asn Tyr Trp Tyr Ser Gln 
            20                  25                  30


Glu Glu Val Val Phe Lys Thr Val Thr Leu Trp Pro Pro Ile Gly Val 
        35                  40                  45


His Ser Gln Leu Arg Asn Ser Leu Ser His Leu 
    50                  55


<210>  1866
<211>  1269
<212>  DNA
<213>  Homo sapiens

<400>  1866
atggggaaag tgtcctgctg tggcatgaaa taaatgaaac agaaaatgat ggcaagactg     60

ctaagaacat cctttgcttt gctcttcctt ggcctctttg gggtgctggg ggcagcaaca    120

atttcatgca gaaatgaaga agggaaagct gtggactggt ttacttttta taagttacct    180

aaaagacaaa acaaggaaag tggagagact gggttagagt acctgtacct agactctaca    240

actagaagct ggaggaagag tgagcaacta atgaatgaca ccaagagtgt tttgggaagg    300

acattacaac agctatatga agcatatgcc tctaagagta acaacacagc ctatctaata    360

tacaatgatg gagtccctaa acctgtgaat tacagcagaa agtatggaca caccaaaggt    420

ttactgctgt ggaacagagt tcaagggttc tggctgattc attccatccc tcagtttcct    480

ccaattccgg aagaaggcta tgattatcca cccacaggga gacgaaatgg acaaagtggc    540

atctgcataa ctttcaagta caaccagtat gaggcaatag attctcagct cttggtctgc    600

aaccccaacg tctatagctg ctccatccca gccacctttc accaggagct cattcacatg    660

ccccagctgt gcaccagggc cagctcatca gagattcctg gcaggctcct caccacactt    720

cagtcggccc agggacaaaa attcctccat tttgcaaagt cggattcttt tcttgacgac    780

atctttgcag cctggatggc tcaacggctg aagacacact tgttaacaga aacctggcag    840

cgaaaaagac aagagcttcc ttcaaactgc tcccttcctt accatgtcta caatataaaa    900

gcaattaaat tatcacgaca ctcttatttc agttcttatc aagatcatgc caagtggtgt    960

atttcccaaa agggcaccaa aaatcgctgg acatgtattg gagacctaaa tcggagtcca   1020

caccaagcct tcagaagtgg aggattcatt tgtacccaga attggcaaat ttaccaagca   1080

tttcaaggat tagtattata ctatgaaagc tgtaagtaaa cttggtgaaa ggacacaggt   1140

actatcattg aaaaccttga caatgggtct tcttccatta caccttcttt atattttaaa   1200

ggcctgtgaa tatacttata acctgcatat cacaaaataa aacatttttc tctcatgttt   1260

accatttaa                                                           1269


<210>  1867
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  1867

Met Lys Gln Lys Met Met Ala Arg Leu Leu Arg Thr Ser Phe Ala Leu 
1               5                   10                  15


Leu Phe Leu Gly Leu Phe Gly Val Leu Gly Ala Ala Thr Ile Ser Cys 
            20                  25                  30


Arg Asn Glu Glu Gly Lys Ala Val Asp Trp Phe Thr Phe Tyr Lys Leu 
        35                  40                  45


Pro Lys Arg Gln Asn Lys Glu Ser Gly Glu Thr Gly Leu Glu Tyr Leu 
    50                  55                  60


Tyr Leu Asp Ser Thr Thr Arg Ser Trp Arg Lys Ser Glu Gln Leu Met 
65                  70                  75                  80


Asn Asp Thr Lys Ser Val Leu Gly Arg Thr Leu Gln Gln Leu Tyr Glu 
                85                  90                  95


Ala Tyr Ala Ser Lys Ser Asn Asn Thr Ala Tyr Leu Ile Tyr Asn Asp 
            100                 105                 110


Gly Val Pro Lys Pro Val Asn Tyr Ser Arg Lys Tyr Gly His Thr Lys 
        115                 120                 125


Gly Leu Leu Leu Trp Asn Arg Val Gln Gly Phe Trp Leu Ile His Ser 
    130                 135                 140


Ile Pro Gln Phe Pro Pro Ile Pro Glu Glu Gly Tyr Asp Tyr Pro Pro 
145                 150                 155                 160


Thr Gly Arg Arg Asn Gly Gln Ser Gly Ile Cys Ile Thr Phe Lys Tyr 
                165                 170                 175


Asn Gln Tyr Glu Ala Ile Asp Ser Gln Leu Leu Val Cys Asn Pro Asn 
            180                 185                 190


Val Tyr Ser Cys Ser Ile Pro Ala Thr Phe His Gln Glu Leu Ile His 
        195                 200                 205


Met Pro Gln Leu Cys Thr Arg Ala Ser Ser Ser Glu Ile Pro Gly Arg 
    210                 215                 220


Leu Leu Thr Thr Leu Gln Ser Ala Gln Gly Gln Lys Phe Leu His Phe 
225                 230                 235                 240


Ala Lys Ser Asp Ser Phe Leu Asp Asp Ile Phe Ala Ala Trp Met Ala 
                245                 250                 255


Gln Arg Leu Lys Thr His Leu Leu Thr Glu Thr Trp Gln Arg Lys Arg 
            260                 265                 270


Gln Glu Leu Pro Ser Asn Cys Ser Leu Pro Tyr His Val Tyr Asn Ile 
        275                 280                 285


Lys Ala Ile Lys Leu Ser Arg His Ser Tyr Phe Ser Ser Tyr Gln Asp 
    290                 295                 300


His Ala Lys Trp Cys Ile Ser Gln Lys Gly Thr Lys Asn Arg Trp Thr 
305                 310                 315                 320


Cys Ile Gly Asp Leu Asn Arg Ser Pro His Gln Ala Phe Arg Ser Gly 
                325                 330                 335


Gly Phe Ile Cys Thr Gln Asn Trp Gln Ile Tyr Gln Ala Phe Gln Gly 
            340                 345                 350


Leu Val Leu Tyr Tyr Glu Ser Cys Lys 
        355                 360


<210>  1868
<211>  1146
<212>  DNA
<213>  Homo sapiens

<400>  1868
taaaaatcat gcacagttaa aaatggactt tctttcccct gtctttcatg tcacaggctt     60

catattgatg gggaagctgc ctattagggg aatagatgac ttctcatgtg tattaatgaa    120

agcaatgtat tgcaggctgg gtagctggta gaaatgttgt gggcgtttgt aagtggaaga    180

tttacgccat tataacccta atatattcct gcagagtaac aacacagcct atctaatata    240

caatgatgga gtccctaaac ctgtgaatta cagcagaaag tatggacaca ccaaaggttt    300

actgctgtgg aacagagttc aagggttctg gctgattcat tccatccctc agtttcctcc    360

aattccggaa gaaggctatg attatccacc cacagggaga cgaaatggac aaagtggcat    420

ctgcataact ttcaagtaca accagtatga ggcaatagat tctcagctct tggtctgcaa    480

ccccaacgtc tatagctgct ccatcccagc cacctttcac caggagctca ttcacatgcc    540

ccagctgtgc accagggcca gctcatcaga gattcctggc aggctcctca ccacacttca    600

gtcggcccag ggacaaaaat tcctccattt tgcaaagtcg gattcttttc ttgacgacat    660

ctttgcagcc tggatggctc aacggctgaa gacacacttg ttaacagaaa cctggcagcg    720

aaaaagacaa gagcttcctt caaactgctc ccttccttac catgtctaca atataaaagc    780

aattaaatta tcacgacact cttatttcag ttcttatcaa gatcatgcca agtggtgtat    840

ttcccaaaag ggcaccaaaa atcgctggac atgtattgga gacctaaatc ggagtccaca    900

ccaagccttc agaagtggag gattcatttg tacccagaat tggcaaattt accaagcatt    960

tcaaggatta gtattatact atgaaagctg taagtaaact tggtgaaagg acacaggtac   1020

tatcattgaa aaccttgaca atgggtcttc ttccattaca ccttctttat attttaaagg   1080

cctgtgaata tacttataac ctgcatatca caaaataaaa catttttctc tcatgtttac   1140

cattta                                                              1146


<210>  1869
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  1869

Met Pro Gln Leu Cys Thr Arg Ala Ser Ser Ser Glu Ile Pro Gly Arg 
1               5                   10                  15


Leu Leu Thr Thr Leu Gln Ser Ala Gln Gly Gln Lys Phe Leu His Phe 
            20                  25                  30


Ala Lys Ser Asp Ser Phe Leu Asp Asp Ile Phe Ala Ala Trp Met Ala 
        35                  40                  45


Gln Arg Leu Lys Thr His Leu Leu Thr Glu Thr Trp Gln Arg Lys Arg 
    50                  55                  60


Gln Glu Leu Pro Ser Asn Cys Ser Leu Pro Tyr His Val Tyr Asn Ile 
65                  70                  75                  80


Lys Ala Ile Lys Leu Ser Arg His Ser Tyr Phe Ser Ser Tyr Gln Asp 
                85                  90                  95


His Ala Lys Trp Cys Ile Ser Gln Lys Gly Thr Lys Asn Arg Trp Thr 
            100                 105                 110


Cys Ile Gly Asp Leu Asn Arg Ser Pro His Gln Ala Phe Arg Ser Gly 
        115                 120                 125


Gly Phe Ile Cys Thr Gln Asn Trp Gln Ile Tyr Gln Ala Phe Gln Gly 
    130                 135                 140


Leu Val Leu Tyr Tyr Glu Ser Cys Lys 
145                 150


<210>  1870
<211>  1303
<212>  DNA
<213>  Homo sapiens

<400>  1870
agaaggctat ttccgtttcc gtacggaagc aaaggagcca agaccatggc gaaagccggg     60

gataagagca gcagcagcgg gaagaaaagt ctaaaacgga aagccgctgc cgaagaactt    120

caggaggctg caggcgctgg ggatggggcg acggaaaacg gggtccaacc cccgaaagcg    180

gctgcctttc cgccaggctt tagcatttcg gagattaaaa acaaacagcg gcgacactta    240

atgttcacgc ggtggaaaca gcagcagcgg aaggaaaagt tggcagctaa gaaaaaactt    300

aaaaaagaaa gagaggctct tggcgataag gctccaccaa agcctgtacc caagaccatt    360

gacaaccagc gagtgtatga tgaaaccaca gtagacccta atgatgaaga ggtcgcttat    420

gatgaagcta cagatgaatt tgcttcttac ttcaacaaac agacttctcc caagattctc    480

atcacaacat cagatagacc tcatgggaga acagtacgac tctgtgaaca gctctccaca    540

gttataccaa actcacatgt ttattacaga agaggactgg ctctgaaaaa aattattcca    600

cagtgcatcg caagagattt cacagacctg attgttatta atgaagatcg taaaacccca    660

aatggactta ttttgagtca cttgccaaat ggcccaactg ctcattttaa aatgagcagt    720

gttcgtcttc gtaaagaaat taagagaaga ggcaaggacc ccacagaaca catacctgaa    780

ataattctga ataattttac aacacggctg ggtcattcaa ttggacgtat gtttgcatct    840

ctctttcctc ataatcctca atttatcgga aggcaggttg ccacattcca caatcaacgg    900

gattacatat tcttcagatt tcacagatac atattcagga gtgaaaagaa agtgggaatt    960

caggaacttg gaccacgttt taccttaaaa ttaaggtctc ttcagaaagg aacctttgat   1020

tctaaatatg gagagtatga atgggtccat aagccccggg aaatggatac aagtagaaga   1080

aaattccatt tataaagtac tgagagaatg atattggatt ttgctgaaca ggcctatctt   1140

gaactttggt aaattatttt tgacagaata ctcttttcaa aatggcattt gctgatttca   1200

taaacctttc acgtctggac gaattaccaa atgccatgaa ttgccactgt gtgtttatgt   1260

agaaaataca aataaaagtt attttgatgg cttaggtttc ctt                     1303


<210>  1871
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  1871

Met Ala Lys Ala Gly Asp Lys Ser Ser Ser Ser Gly Lys Lys Ser Leu 
1               5                   10                  15


Lys Arg Lys Ala Ala Ala Glu Glu Leu Gln Glu Ala Ala Gly Ala Gly 
            20                  25                  30


Asp Gly Ala Thr Glu Asn Gly Val Gln Pro Pro Lys Ala Ala Ala Phe 
        35                  40                  45


Pro Pro Gly Phe Ser Ile Ser Glu Ile Lys Asn Lys Gln Arg Arg His 
    50                  55                  60


Leu Met Phe Thr Arg Trp Lys Gln Gln Gln Arg Lys Glu Lys Leu Ala 
65                  70                  75                  80


Ala Lys Lys Lys Leu Lys Lys Glu Arg Glu Ala Leu Gly Asp Lys Ala 
                85                  90                  95


Pro Pro Lys Pro Val Pro Lys Thr Ile Asp Asn Gln Arg Val Tyr Asp 
            100                 105                 110


Glu Thr Thr Val Asp Pro Asn Asp Glu Glu Val Ala Tyr Asp Glu Ala 
        115                 120                 125


Thr Asp Glu Phe Ala Ser Tyr Phe Asn Lys Gln Thr Ser Pro Lys Ile 
    130                 135                 140


Leu Ile Thr Thr Ser Asp Arg Pro His Gly Arg Thr Val Arg Leu Cys 
145                 150                 155                 160


Glu Gln Leu Ser Thr Val Ile Pro Asn Ser His Val Tyr Tyr Arg Arg 
                165                 170                 175


Gly Leu Ala Leu Lys Lys Ile Ile Pro Gln Cys Ile Ala Arg Asp Phe 
            180                 185                 190


Thr Asp Leu Ile Val Ile Asn Glu Asp Arg Lys Thr Pro Asn Gly Leu 
        195                 200                 205


Ile Leu Ser His Leu Pro Asn Gly Pro Thr Ala His Phe Lys Met Ser 
    210                 215                 220


Ser Val Arg Leu Arg Lys Glu Ile Lys Arg Arg Gly Lys Asp Pro Thr 
225                 230                 235                 240


Glu His Ile Pro Glu Ile Ile Leu Asn Asn Phe Thr Thr Arg Leu Gly 
                245                 250                 255


His Ser Ile Gly Arg Met Phe Ala Ser Leu Phe Pro His Asn Pro Gln 
            260                 265                 270


Phe Ile Gly Arg Gln Val Ala Thr Phe His Asn Gln Arg Asp Tyr Ile 
        275                 280                 285


Phe Phe Arg Phe His Arg Tyr Ile Phe Arg Ser Glu Lys Lys Val Gly 
    290                 295                 300


Ile Gln Glu Leu Gly Pro Arg Phe Thr Leu Lys Leu Arg Ser Leu Gln 
305                 310                 315                 320


Lys Gly Thr Phe Asp Ser Lys Tyr Gly Glu Tyr Glu Trp Val His Lys 
                325                 330                 335


Pro Arg Glu Met Asp Thr Ser Arg Arg Lys Phe His Leu 
            340                 345


<210>  1872
<211>  3476
<212>  DNA
<213>  Homo sapiens

<400>  1872
agaaggctat ttccgtttcc gtacggaagc aaaggagcca agaccatggc gaaagccggg     60

gataagagca gcagcagcgg gaagaaaagt ctaaaacgga aagccgctgc cgaagaactt    120

caggaggctg caggcgctgg ggatggggcg acggaaaacg gggtccaacc cccgaaagcg    180

gctgcctttc cgccaggctt tagcatttcg gagattaaaa acaaacagcg gcgacactta    240

atgttcacgc ggtggaaaca gcagcagcgg aaggaaaagt tggcagctaa gaaaaaactt    300

aaaaaagaaa gagaggctct tggcgataag gctccaccaa agcctgtacc caagaccatt    360

gacaaccagc gagtgtatga tgaaaccaca gtagacccta atgatgaaga ggtcgcttat    420

gatgaagcta cagatgaatt tgcttcttac ttcaacaaac agacttctcc caagattctc    480

atcacaacat cagatagacc tcatgggaga acagtacgac tctgtgaaca gctctccaca    540

gttataccaa actcacatgt ttattacaga agaggactgg ctctgaaaaa aattattcca    600

cagtgcatcg caagagattt cacagacctg attgttatta atgaagatcg taaaacccca    660

aatggactta ttttgagtca cttgccaaat ggcccaactg ctcattttaa aatgagcagt    720

gttcgtcttc gtaaagaaat taagagaaga ggcaaggacc ccacagaaca catacctgaa    780

ataattctga ataattttac aacacggctg ggtcattcaa ttggacgtat gtttgcatct    840

ctctttcctc ataatcctca atttatcgga aggcaggttg ccacattcca caatcaacgg    900

gattacatat tcttcagatt tcacagatac atattcagga gtgaaaagaa agtgggaatt    960

caggaacttg gaccacgttt taccttaaaa ttaaggtctc ttcagaaagg aacctttgat   1020

tctaaatatg gagagtatga atgggtccat aagccccggg aaatggatac aagtagaaga   1080

aaattccatt tataaagtac tgagagaatg atattggatt ttgctgaaca ggcctatctt   1140

gaactttggt aaattatttt tgacagaata ctcttttcaa aatggcattt gctgatttca   1200

taaacctttc acgtctggac gaattaccaa atgccatgaa ttgccactgt gtgtttatgt   1260

agaaaataca aataaaagtt attttgatgg cttaggtttc cttaaactta gttctcttgt   1320

ttttgggtaa ctgtgaataa ttaagttgga atcaagattc agattaactt tcctatttgc   1380

atagaacaca tgagaggaat aaaatggttg gtaaatattg gctaaccctt gatttttata   1440

ccagattaac cttggattcc cagtgtctgg cacagtttta atagcttaaa tggaggccag   1500

gtttctggat gttttaacat tctcttaagc cttcagaagg gtaaaaaatt taaagcaaaa   1560

tgatctacca gggtttaaag caaagttgca aattactgaa gctaatcttt gcttcctgat   1620

tttgaggttt ttggtttttt gtgcccacgt tgtggggagc tcttttttac ctcattacat   1680

ggtgctgtag tactccattc aggcactgaa acaaagttaa ccctataagt aactcatgga   1740

tggaaacccg tagaacttaa cagcctcctc ctgaccttaa aagaataaag gttcacagtt   1800

tacctttaat tccctagcag tcttgccaga tgtatggcat aaagtcatgt gagaagagta   1860

ggtggaaaaa actgtacaaa cttaacccct tcaggtgttc agaacagatt aatataccat   1920

gtatttaata ccaataataa tgcaaaataa aagtttcata ctaagtttta ttgtatgctg   1980

ctgccagtgt atataaaaca attacccttg tgaaatagaa attcatgaaa attcagagag   2040

gtagatgtta aggactgacg aaagtagaag tttgtatatt atggcacatg tgttacaggg   2100

ataagctttt gtacaggctt caaatgtagc tctcttgaat attcactgga tcataaggag   2160

tggtttggga aacctaagat ggggaaaaaa aaaaaaaggt gagttagggt aaagtatcaa   2220

agaacatagt ttttaatttt tttcatgaat aacttaaaag aagcaggatg ggaaatgcct   2280

atggtccagt aacagtaaaa tctttccctt aattttcaca accactctga tgtataagtc   2340

attcctgttt tataaacaga cttacagatt aacttgctaa gattactgcc aaaatacatt   2400

ctgtatataa taaaaaaggt taataaaact ctcttaaatc aaaaatccaa acatccttag   2460

aaaaatgagc aagactatat ttagcagggc agtttggcag tatctagtga agtaaaggat   2520

gcaaccacac ttctagttac ctagataaac ccagacatag agaaacatgt acaaggatac   2580

tgactgtatt agtattttaa cagcaaagaa ctgaaacagc ctaaatataa ctccgtagga   2640

gaatggataa acgaaggttt ctacatatga tggaatacaa agctattata agttatgcct   2700

taaaaaataa gttatgtttt caaaccataa tatttcagtt taatagagta taaactaaaa   2760

gatttaaaaa atgaaaacat taaattgaaa aacagtgtac taaaaaatta aaacatgagc   2820

atactaactt taggattagt tattgatatg gaaaggtaca aaagtgttaa tctgagatag   2880

tctgtgacaa aaatgttgaa aaggcataaa cagaatgctg tgaaaaatgt ttaatctcac   2940

ctaaaatagt gacagaaaag actaaggttt gttaggactc aaggaaaaaa cattctcatg   3000

tttctagtgg aaggccaaag tattatattg gcaggggata tcaagtacaa cgttgtaaaa   3060

atgttaaacg ttcactcctt tttacttcta gaaacttaat agaggtacta agtatatata   3120

gatgttcacc aaaatcttca cctcactgta acctcaaatt ttggaaactt aaatattcag   3180

tgaagtataa ttccatcata gtttagtaca accattaaat atcttgttta caaagagtat   3240

ttaatgaaat aaattcattt aaaaaaggca gaatgaaaaa cggcgaatac tgtcaataag   3300

cctgtcgtct tatctgcatt tttttgtgca tacatgttct actgattaac agtttttaat   3360

cctgtgttat tctattttgt tttgtgtaaa agaggaaaaa tttcaaaagc tggaatctca   3420

aaaaaaatag taaaatttcc tcttaaaagg aaatacaggg ccgggcacgg tggctc       3476


<210>  1873
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  1873

Met Ala Lys Ala Gly Asp Lys Ser Ser Ser Ser Gly Lys Lys Ser Leu 
1               5                   10                  15


Lys Arg Lys Ala Ala Ala Glu Glu Leu Gln Glu Ala Ala Gly Ala Gly 
            20                  25                  30


Asp Gly Ala Thr Glu Asn Gly Val Gln Pro Pro Lys Ala Ala Ala Phe 
        35                  40                  45


Pro Pro Gly Phe Ser Ile Ser Glu Ile Lys Asn Lys Gln Arg Arg His 
    50                  55                  60


Leu Met Phe Thr Arg Trp Lys Gln Gln Gln Arg Lys Glu Lys Leu Ala 
65                  70                  75                  80


Ala Lys Lys Lys Leu Lys Lys Glu Arg Glu Ala Leu Gly Asp Lys Ala 
                85                  90                  95


Pro Pro Lys Pro Val Pro Lys Thr Ile Asp Asn Gln Arg Val Tyr Asp 
            100                 105                 110


Glu Thr Thr Val Asp Pro Asn Asp Glu Glu Val Ala Tyr Asp Glu Ala 
        115                 120                 125


Thr Asp Glu Phe Ala Ser Tyr Phe Asn Lys Gln Thr Ser Pro Lys Ile 
    130                 135                 140


Leu Ile Thr Thr Ser Asp Arg Pro His Gly Arg Thr Val Arg Leu Cys 
145                 150                 155                 160


Glu Gln Leu Ser Thr Val Ile Pro Asn Ser His Val Tyr Tyr Arg Arg 
                165                 170                 175


Gly Leu Ala Leu Lys Lys Ile Ile Pro Gln Cys Ile Ala Arg Asp Phe 
            180                 185                 190


Thr Asp Leu Ile Val Ile Asn Glu Asp Arg Lys Thr Pro Asn Gly Leu 
        195                 200                 205


Ile Leu Ser His Leu Pro Asn Gly Pro Thr Ala His Phe Lys Met Ser 
    210                 215                 220


Ser Val Arg Leu Arg Lys Glu Ile Lys Arg Arg Gly Lys Asp Pro Thr 
225                 230                 235                 240


Glu His Ile Pro Glu Ile Ile Leu Asn Asn Phe Thr Thr Arg Leu Gly 
                245                 250                 255


His Ser Ile Gly Arg Met Phe Ala Ser Leu Phe Pro His Asn Pro Gln 
            260                 265                 270


Phe Ile Gly Arg Gln Val Ala Thr Phe His Asn Gln Arg Asp Tyr Ile 
        275                 280                 285


Phe Phe Arg Phe His Arg Tyr Ile Phe Arg Ser Glu Lys Lys Val Gly 
    290                 295                 300


Ile Gln Glu Leu Gly Pro Arg Phe Thr Leu Lys Leu Arg Ser Leu Gln 
305                 310                 315                 320


Lys Gly Thr Phe Asp Ser Lys Tyr Gly Glu Tyr Glu Trp Val His Lys 
                325                 330                 335


Pro Arg Glu Met Asp Thr Ser Arg Arg Lys Phe His Leu 
            340                 345


<210>  1874
<211>  724
<212>  DNA
<213>  Homo sapiens

<400>  1874
acggaagcaa aggagccaag accatggcga aagccgggga taagagcagc agcagcggga     60

agaaaagtct aaaacggaaa gccgctgccg aagaacttca ggaggctgca ggcgctgggg    120

atggggcgac ggaaaacggg gtccaacccc cgaaagcggc tgcctttccg ccaggcttta    180

gcatttcgga gattaaaaac aaacagcggc gacacttaat gttcacgcgg tggaaacagc    240

agcagcggaa ggaaaagttg gcagctaaga aaaaacttaa aaaagaaaga gaggctcttg    300

gcgataaggc tccaccaaag cctgtaccca agaccattga caaccagcga gtgtatgatg    360

aaaccacagt agaccctaat gatgaagagg taatgttaga agtcttaaat tagtttgaat    420

gatcacatat aattgataaa ttatatgttt ttttgttgat atttaaagtg ctggctggcc    480

aagttgcata atggactgat tcagctaaaa tgttggcata ttatcttatt atttggtgaa    540

gactatttca taattgaatt tcccaataat gctatagaaa aattctataa aaattctagg    600

taaactttta catttgtcat ataatccctg aatggtattt tggagggttt tgtttttgtt    660

tttgtttttg attttgttga gacagagtct tgctctgtcg cccatgctgg agtgcagtgg    720

tgtg                                                                 724


<210>  1875
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  1875

Met Ala Lys Ala Gly Asp Lys Ser Ser Ser Ser Gly Lys Lys Ser Leu 
1               5                   10                  15


Lys Arg Lys Ala Ala Ala Glu Glu Leu Gln Glu Ala Ala Gly Ala Gly 
            20                  25                  30


Asp Gly Ala Thr Glu Asn Gly Val Gln Pro Pro Lys Ala Ala Ala Phe 
        35                  40                  45


Pro Pro Gly Phe Ser Ile Ser Glu Ile Lys Asn Lys Gln Arg Arg His 
    50                  55                  60


Leu Met Phe Thr Arg Trp Lys Gln Gln Gln Arg Lys Glu Lys Leu Ala 
65                  70                  75                  80


Ala Lys Lys Lys Leu Lys Lys Glu Arg Glu Ala Leu Gly Asp Lys Ala 
                85                  90                  95


Pro Pro Lys Pro Val Pro Lys Thr Ile Asp Asn Gln Arg Val Tyr Asp 
            100                 105                 110


Glu Thr Thr Val Asp Pro Asn Asp Glu Glu Val Met Leu Glu Val Leu 
        115                 120                 125


Asn 



<210>  1876
<211>  830
<212>  DNA
<213>  Homo sapiens

<400>  1876
acggaagcaa aggagccaag accatggcga aagccgggga taagagcagc agcagcggga     60

agaaaagtct aaaacggaaa gccgctgccg aagaacttca ggaggctgca ggcgctgggg    120

atggggcgac ggaaaacggg gtccaacccc cgaaagcggc tgcctttccg ccaggcttta    180

gcatttcgga gattaaaaac aaacagcggc gacacttaat gttcacgcgg tggaaacagc    240

agcagcggaa ggaaaagttg gcagctaaga aaaaacttaa aaaagaaaga gaggctcttg    300

gcgataaggc tccaccaaag cctgtaccca agaccattga caaccagcga gtgtatgatg    360

aaaccacagt agaccctaat gatgaagagg tcgcttatga tgaagctaca gatgaatttg    420

cttcttactt caacaaacag acttctccca agattctcat cacaacatca gatagacctc    480

atgggagaac agtacgactc tgtgaacagc tctccacagt tataccaaac tcacatgttt    540

attacagaag aggactggct ctgaaaaaaa ttattccaca gtgcatcgca agagatttca    600

cagacctgat tgttattaat gaagatcgta aaaccccaag tatccttttt ttttttaagg    660

aggttttcct gtcctctccc tcacccccct taaaaatata tttaaaagaa taaggaaata    720

ttgcctataa ctttcagaaa ataatttttt tatcagaaaa ttgtatctct ttccaagagt    780

ctataaactg atttttcctt tgtattcacc aaacatttat caggcacatg               830


<210>  1877
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  1877

Met Ala Lys Ala Gly Asp Lys Ser Ser Ser Ser Gly Lys Lys Ser Leu 
1               5                   10                  15


Lys Arg Lys Ala Ala Ala Glu Glu Leu Gln Glu Ala Ala Gly Ala Gly 
            20                  25                  30


Asp Gly Ala Thr Glu Asn Gly Val Gln Pro Pro Lys Ala Ala Ala Phe 
        35                  40                  45


Pro Pro Gly Phe Ser Ile Ser Glu Ile Lys Asn Lys Gln Arg Arg His 
    50                  55                  60


Leu Met Phe Thr Arg Trp Lys Gln Gln Gln Arg Lys Glu Lys Leu Ala 
65                  70                  75                  80


Ala Lys Lys Lys Leu Lys Lys Glu Arg Glu Ala Leu Gly Asp Lys Ala 
                85                  90                  95


Pro Pro Lys Pro Val Pro Lys Thr Ile Asp Asn Gln Arg Val Tyr Asp 
            100                 105                 110


Glu Thr Thr Val Asp Pro Asn Asp Glu Glu Val Ala Tyr Asp Glu Ala 
        115                 120                 125


Thr Asp Glu Phe Ala Ser Tyr Phe Asn Lys Gln Thr Ser Pro Lys Ile 
    130                 135                 140


Leu Ile Thr Thr Ser Asp Arg Pro His Gly Arg Thr Val Arg Leu Cys 
145                 150                 155                 160


Glu Gln Leu Ser Thr Val Ile Pro Asn Ser His Val Tyr Tyr Arg Arg 
                165                 170                 175


Gly Leu Ala Leu Lys Lys Ile Ile Pro Gln Cys Ile Ala Arg Asp Phe 
            180                 185                 190


Thr Asp Leu Ile Val Ile Asn Glu Asp Arg Lys Thr Pro Ser Ile Leu 
        195                 200                 205


Phe Phe Phe Lys Glu Val Phe Leu Ser Ser Pro Ser Pro Pro Leu Lys 
    210                 215                 220


Ile Tyr Leu Lys Glu 
225


<210>  1878
<211>  1367
<212>  DNA
<213>  Homo sapiens

<400>  1878
tttctttaga catgttgcta aatgtggttt aacgttgtgt atctgtttta tcaatgactg     60

ggctaggtga tttttttgtg agatttttaa actagcacaa tcttactttt aacctttatg    120

tgtgagtaca attgatagaa cttaccataa gtgcttgaca aactgtcata ggtaggtcag    180

gacatttttg agagtgagaa ggggcactaa taggccagga ttacagggtt tcaacctcct    240

ggatggtgat tgttacagtg ccttaggggc tagcagcttg ttccagtttt agagtctttg    300

tctcagcttt cctcactgtt tggaatgctg tttctcactg atggttattt ggctggatct    360

cttgtcattg agatctcagc ttcaatgtca cctcagacac cttcccttag gtgggcaccc    420

agtcaccatc taaaagatta ttcattttac tacagagcac cttgtctgtc attttctctg    480

aactgttagc tccataacaa cagggctctg gctgttctta tgtattctta gtgcctgtaa    540

gtatatgcgg cacatagtgg tgcttgaaaa ttgtgaaagc gagttacatt ggaccccacc    600

tacactttaa acagaaaatt aacaggtttc ccaggcagct gcagacttga aacagttctg    660

tctgcagaat gctcaacatg accctctgct gactggagta tcttcaagta caaatccctt    720

cagaccccag aaagtctgtt cctttttgta gtaaaatgaa tctttcaaag gtttcccaaa    780

ccactcctta tgatccagtg aatattcaag agagctacat ttgaagcctg tacaaaagct    840

tatccctgta acacatgtgc cataatatac aaacttctac tttcgtcagt ccttaacatc    900

tacctctctg aattttcatg aatttctatt tcacaagggt aattgtttta tatacactgg    960

cagcagcata caataaaact tagtatgaaa cttttatttt gcattattat tggtattaaa   1020

tacatggtat attaatctgt tctgaacacc tgaaggggtt aagtttgtac agttttttcc   1080

acctactctt ctcacatgac tttatgccat acatctggca agactgctag ggaattaaag   1140

gtaaactgtg aacctttatt cttttaaggt caggaggagg ctgttaagtt ctacgggttt   1200

ccatccatga gttacttata gggttaactt tgtttcagtg cctgaatgga gtactacagc   1260

accatgtaat gaggtaaaaa agagctcccc acaacgtggg cacaaaaaac caaaaacctc   1320

aaaatcagga agcaaagatt agcttcagta atttgcaact ttgcttt                 1367


<210>  1879
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  1879

Met Leu Phe Leu Thr Asp Gly Tyr Leu Ala Gly Ser Leu Val Ile Glu 
1               5                   10                  15


Ile Ser Ala Ser Met Ser Pro Gln Thr Pro Ser Leu Arg Trp Ala Pro 
            20                  25                  30


Ser His His Leu Lys Asp Tyr Ser Phe Tyr Tyr Arg Ala Pro Cys Leu 
        35                  40                  45


Ser Phe Ser Leu Asn Cys 
    50


<210>  1880
<211>  1310
<212>  DNA
<213>  Homo sapiens

<400>  1880
acttccctca acccttccca caaactggga ggaaaactga gacctcctgg tcacccgccg     60

ccgggccttt tagaaactcc cacaagctct gccttccctc cctggtcctc ttcagacccc    120

ctcttagttc ttcgcggcta acggtaagct ctctccttac ctctccctaa tcggcccctc    180

tggagaggaa aagaaaactt aagagtcggg tcgcgctagc ctccagcagc cgccgcgccc    240

accgactgct ccgccccttc tcctccccct cctccaggct cgcgctcggg gccgggtgtg    300

gagctggaac agagggctgg caaggcgcgc atgcgcaccg agggtggagc cgctgagcac    360

agaaccggaa acttagagac aaagttcgga gccccgcccc cgccgcgcgc cgctgagttg    420

tctggccccg ccgacccacg gcccacgacc caccgaccca cgaatcggcc cggccgtcgc    480

gtgcaccatg tctggctcct ccagcgtcgc cgctatgaag aaagtggttc aacagctccg    540

gctggaggcc ggactcaacc gcgtaaaagt ttcccaggca gctgcagact tgaaacagtt    600

ctgtctgcag aatgctcaac atgaccctct gctgactgga gtatcttcaa gtacaaatcc    660

cttcagaccc cagaaagtct gttccttttt gtagtaaaat gaatctttca aaggtttccc    720

aaaccactcc ttatgatcca gtgaatattc aagagagcta catttgaagc ctgtacaaaa    780

gcttatccct gtaacacatg tgccataata tacaaacttc tactttcgtc agtccttaac    840

atctacctct ctgaattttc atgaatttct atttcacaag ggtaattgtt ttatatacac    900

tggcagcagc atacaataaa acttagtatg aaacttttat tttgcattat tattggtatt    960

aaatacatgg tatattaatc tgttctgaac acctgaaggg gttaagtttg tacagttttt   1020

tccacctact cttctcacat gactttatgc catacatctg gcaagactgc tagggaatta   1080

aaggtaaact gtgaaccttt attcttttaa ggtcaggagg aggctgttaa gttctacggg   1140

tttccatcca tgagttactt atagggttaa ctttgtttca gtgcctgaat ggagtactac   1200

agcaccatgt aatgaggtaa aaaagagctc cccacaacgt gggcacaaaa aaccaaaaac   1260

ctcaaaatca ggaagcaaag attagcttca gtaatttgca actttgcttt              1310


<210>  1881
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  1881

Met Arg Thr Glu Gly Gly Ala Ala Glu His Arg Thr Gly Asn Leu Glu 
1               5                   10                  15


Thr Lys Phe Gly Ala Pro Pro Pro Pro Arg Ala Ala Glu Leu Ser Gly 
            20                  25                  30


Pro Ala Asp Pro Arg Pro Thr Thr His Arg Pro Thr Asn Arg Pro Gly 
        35                  40                  45


Arg Arg Val His His Val Trp Leu Leu Gln Arg Arg Arg Tyr Glu Glu 
    50                  55                  60


Ser Gly Ser Thr Ala Pro Ala Gly Gly Arg Thr Gln Pro Arg Lys Ser 
65                  70                  75                  80


Phe Pro Gly Ser Cys Arg Leu Glu Thr Val Leu Ser Ala Glu Cys Ser 
                85                  90                  95


Thr 



<210>  1882
<211>  1193
<212>  DNA
<213>  Homo sapiens

<400>  1882
acccagtatc tcccctcact tccctcaacc cttcccacaa actgggagga aaactgagac     60

ctcctggtca cccgccgccg ggccttttag aaactcccac aagctctgcc ttccctccct    120

ggtcctcttc agaccccctc ttagttcttc gcggctaacg gctcgcgctc ggggccgggt    180

gtggagctgg aacagagggc tggcaaggcg cgcatgcgca ccgagggtgg agccgctgag    240

cacagaaccg gaaacttaga gacaaagttc ggagccccgc ccccgccgcg cgccgctgag    300

ttgtctggcc ccgccgaccc acggcccacg acccaccgac ccacgaatcg gcccggccgt    360

cgcgtgcacc atgtctggct cctccagcgt cgccgctatg aagaaagtgg ttcaacagct    420

ccggctggag gccggactca accgcgtaaa agtttcccag gcagctgcag acttgaaaca    480

gttctgtctg cagaatgctc aacatgaccc tctgctgact ggagtatctt caagtacaaa    540

tcccttcaga ccccagaaag tctgttcctt tttgtagtaa aatgaatctt tcaaaggttt    600

cccaaaccac tccttatgat ccagtgaata ttcaagagag ctacatttga agcctgtaca    660

aaagcttatc cctgtaacac atgtgccata atatacaaac ttctactttc gtcagtcctt    720

aacatctacc tctctgaatt ttcatgaatt tctatttcac aagggtaatt gttttatata    780

cactggcagc agcatacaat aaaacttagt atgaaacttt tattttgcat tattattggt    840

attaaataca tggtatatta atctgttctg aacacctgaa ggggttaagt ttgtacagtt    900

ttttccacct actcttctca catgacttta tgccatacat ctggcaagac tgctagggaa    960

ttaaaggtaa actgtgaacc tttattcttt taaggtcagg aggaggctgt taagttctac   1020

gggtttccat ccatgagtta cttatagggt taactttgtt tcagtgcctg aatggagtac   1080

tacagcacca tgtaatgagg taaaaaagag ctccccacaa cgtgggcaca aaaaaccaaa   1140

aacctcaaaa tcaggaagca aagattagct tcagtaattt gcaactttgc ttt          1193


<210>  1883
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  1883

Met Arg Thr Glu Gly Gly Ala Ala Glu His Arg Thr Gly Asn Leu Glu 
1               5                   10                  15


Thr Lys Phe Gly Ala Pro Pro Pro Pro Arg Ala Ala Glu Leu Ser Gly 
            20                  25                  30


Pro Ala Asp Pro Arg Pro Thr Thr His Arg Pro Thr Asn Arg Pro Gly 
        35                  40                  45


Arg Arg Val His His Val Trp Leu Leu Gln Arg Arg Arg Tyr Glu Glu 
    50                  55                  60


Ser Gly Ser Thr Ala Pro Ala Gly Gly Arg Thr Gln Pro Arg Lys Ser 
65                  70                  75                  80


Phe Pro Gly Ser Cys Arg Leu Glu Thr Val Leu Ser Ala Glu Cys Ser 
                85                  90                  95


Thr 



<210>  1884
<211>  1002
<212>  DNA
<213>  Homo sapiens

<400>  1884
tttctttaga catgttgcta aatgtggttt aacgttgtgt atctgtttta tcaatgactg     60

ggctaggtga tttttttgtg agatttttaa actagcacaa tcttactttt aacctttatg    120

tgtgagtaca attgatagaa cttaccataa gtgcttgaca aactgtcata ggtaggtcag    180

gacatttttg agagtgagaa ggggcactaa taggccagga ttacagggtt tcaacctcct    240

ggatggtgat tgttacagtg ccttaggggc tagcagcttg ttccagtttt agagtctttg    300

tctcagcttt cctcactgtt tggaatgctg tttctcactg atggttattt ggctggatct    360

cttgtcattg agatctcagc ttcaatgtca cctcagacac cttcccttag gtgggcaccc    420

agtcaccatc taaaagatta ttcattttac tacagagcac cttgtctgtc attttctctg    480

aactgttagc tccataacaa cagggctctg gctgttctta tgtattctta gtgcctgtaa    540

gtatatgcgg cacatagtgg tgcttgaaaa ttgtgaaagc gagttacatt ggaccccacc    600

tacactttaa acagaaaatt aacaggtttc ccaggcagct gcagacttga aacagttctg    660

tctgcagaat gctcaacatg accctctgct gactggagta tcttcaagta caaatccctt    720

cagaccccag aaagtctgtt cctttttgta gtaaaatgaa tctttcaaag gtttcccaaa    780

ccactcctta tgatccagtg aatattcaag agagctacat ttgaagcctg tacaaaagct    840

tatccctgta acacatgtgc cataatatac aaacttctac tttcgtcagt ccttaacatc    900

tacctctctg aattttcatg aatttctatt tcacaagggt aattgtttta tatacactgg    960

cagcagcata caataaaact tagtatgaaa cttttatttt gc                      1002


<210>  1885
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  1885

Met Leu Phe Leu Thr Asp Gly Tyr Leu Ala Gly Ser Leu Val Ile Glu 
1               5                   10                  15


Ile Ser Ala Ser Met Ser Pro Gln Thr Pro Ser Leu Arg Trp Ala Pro 
            20                  25                  30


Ser His His Leu Lys Asp Tyr Ser Phe Tyr Tyr Arg Ala Pro Cys Leu 
        35                  40                  45


Ser Phe Ser Leu Asn Cys 
    50


<210>  1886
<211>  945
<212>  DNA
<213>  Homo sapiens

<400>  1886
acttccctca acccttccca caaactggga ggaaaactga gacctcctgg tcacccgccg     60

ccgggccttt tagaaactcc cacaagctct gccttccctc cctggtcctc ttcagacccc    120

ctcttagttc ttcgcggcta acggtaagct ctctccttac ctctccctaa tcggcccctc    180

tggagaggaa aagaaaactt aagagtcggg tcgcgctagc ctccagcagc cgccgcgccc    240

accgactgct ccgccccttc tcctccccct cctccaggct cgcgctcggg gccgggtgtg    300

gagctggaac agagggctgg caaggcgcgc atgcgcaccg agggtggagc cgctgagcac    360

agaaccggaa acttagagac aaagttcgga gccccgcccc cgccgcgcgc cgctgagttg    420

tctggccccg ccgacccacg gcccacgacc caccgaccca cgaatcggcc cggccgtcgc    480

gtgcaccatg tctggctcct ccagcgtcgc cgctatgaag aaagtggttc aacagctccg    540

gctggaggcc ggactcaacc gcgtaaaagt ttcccaggca gctgcagact tgaaacagtt    600

ctgtctgcag aatgctcaac atgaccctct gctgactgga gtatcttcaa gtacaaatcc    660

cttcagaccc cagaaagtct gttccttttt gtagtaaaat gaatctttca aaggtttccc    720

aaaccactcc ttatgatcca gtgaatattc aagagagcta catttgaagc ctgtacaaaa    780

gcttatccct gtaacacatg tgccataata tacaaacttc tactttcgtc agtccttaac    840

atctacctct ctgaattttc atgaatttct atttcacaag ggtaattgtt ttatatacac    900

tggcagcagc atacaataaa acttagtatg aaacttttat tttgc                    945


<210>  1887
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  1887

Met Arg Thr Glu Gly Gly Ala Ala Glu His Arg Thr Gly Asn Leu Glu 
1               5                   10                  15


Thr Lys Phe Gly Ala Pro Pro Pro Pro Arg Ala Ala Glu Leu Ser Gly 
            20                  25                  30


Pro Ala Asp Pro Arg Pro Thr Thr His Arg Pro Thr Asn Arg Pro Gly 
        35                  40                  45


Arg Arg Val His His Val Trp Leu Leu Gln Arg Arg Arg Tyr Glu Glu 
    50                  55                  60


Ser Gly Ser Thr Ala Pro Ala Gly Gly Arg Thr Gln Pro Arg Lys Ser 
65                  70                  75                  80


Phe Pro Gly Ser Cys Arg Leu Glu Thr Val Leu Ser Ala Glu Cys Ser 
                85                  90                  95


Thr 



<210>  1888
<211>  828
<212>  DNA
<213>  Homo sapiens

<400>  1888
acccagtatc tcccctcact tccctcaacc cttcccacaa actgggagga aaactgagac     60

ctcctggtca cccgccgccg ggccttttag aaactcccac aagctctgcc ttccctccct    120

ggtcctcttc agaccccctc ttagttcttc gcggctaacg gctcgcgctc ggggccgggt    180

gtggagctgg aacagagggc tggcaaggcg cgcatgcgca ccgagggtgg agccgctgag    240

cacagaaccg gaaacttaga gacaaagttc ggagccccgc ccccgccgcg cgccgctgag    300

ttgtctggcc ccgccgaccc acggcccacg acccaccgac ccacgaatcg gcccggccgt    360

cgcgtgcacc atgtctggct cctccagcgt cgccgctatg aagaaagtgg ttcaacagct    420

ccggctggag gccggactca accgcgtaaa agtttcccag gcagctgcag acttgaaaca    480

gttctgtctg cagaatgctc aacatgaccc tctgctgact ggagtatctt caagtacaaa    540

tcccttcaga ccccagaaag tctgttcctt tttgtagtaa aatgaatctt tcaaaggttt    600

cccaaaccac tccttatgat ccagtgaata ttcaagagag ctacatttga agcctgtaca    660

aaagcttatc cctgtaacac atgtgccata atatacaaac ttctactttc gtcagtcctt    720

aacatctacc tctctgaatt ttcatgaatt tctatttcac aagggtaatt gttttatata    780

cactggcagc agcatacaat aaaacttagt atgaaacttt tattttgc                 828


<210>  1889
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  1889

Met Arg Thr Glu Gly Gly Ala Ala Glu His Arg Thr Gly Asn Leu Glu 
1               5                   10                  15


Thr Lys Phe Gly Ala Pro Pro Pro Pro Arg Ala Ala Glu Leu Ser Gly 
            20                  25                  30


Pro Ala Asp Pro Arg Pro Thr Thr His Arg Pro Thr Asn Arg Pro Gly 
        35                  40                  45


Arg Arg Val His His Val Trp Leu Leu Gln Arg Arg Arg Tyr Glu Glu 
    50                  55                  60


Ser Gly Ser Thr Ala Pro Ala Gly Gly Arg Thr Gln Pro Arg Lys Ser 
65                  70                  75                  80


Phe Pro Gly Ser Cys Arg Leu Glu Thr Val Leu Ser Ala Glu Cys Ser 
                85                  90                  95


Thr 



<210>  1890
<211>  1324
<212>  DNA
<213>  Homo sapiens

<400>  1890
cgagcgcgag cctggaggag ggggaggaga aggggcggag cagtcggtgg gcgcggcggc     60

tgctggaggc tagcgcgacc cgactcttaa gttttctttt cctctccaga ggggccgatt    120

agggagagag accagaaatg agtggaatgc tatcttaagc caaaaaaaac tattataatt    180

tttatttagt actacttaaa tgaagaaaga taaaaaaaga aacaaaattc caattgataa    240

ttatcccatt cagacattag tgaatatgtc actcaatcca agtcgacctt cctcatcaga    300

gttggtggaa cttcatgttt tttatgtccc tgaaggatca tggaactata agctaaatac    360

catttcaaca gaagttgtta acaaattcat ttcagctgga tttctaaggc aatatctcct    420

caacttactt tacgagccct gagggagcgt cttggtgagt tcctgggtga agatgctatt    480

gcagaaaaat ttttatttct gaaatgcatt ggaaataatt tagctgtggt gaaggaaaag    540

caagaatcag aactgaaact caaatcattt gctcctccat atgctcttca accagaatta    600

tatttgcttc ctgtaatgga ccatttagga aatgtttatt caccatcaac agttatttta    660

gatgagcggc agactaataa tggtgttaat gaggctgatg gaacaatcca cagaccaatt    720

agtgtaactt tgttcaagga ggaacttgga agagatccca gtttgttaga aaacactttg    780

aaagagcttc ctaacaagaa tcaggaagaa ggtgatttta aactggaatg ggaaaaagaa    840

agaggctatt atagtacatt ttagcagtca agtctgtaag caaaccctga gcaaacctag    900

ccttacaaat ataggcagtt taaaaagaaa gctacaattc cacttgggga tttctaaaaa    960

aatatttttg ccagatggga ggaaaagaaa acaatttaag tactatgtta aaataaaaac   1020

aaaatcaaaa tagttacagc acttaaatga acattaccac ctttacttct tttttaataa   1080

aatagtttta gataaaagta aagctacagg ggaagagaaa ggaaaggtga ctgcataaaa   1140

ctttggtatt actcagagac cagagggatc aggaaaacag tatcaaacca agacagacaa   1200

caacaacaaa aaaactttaa tgttggggaa catacgtatt tcagagaatt ttaaattttt   1260

tatctgatta cacctatcaa tttactaata attactaata actcaattct tcaaaagtga   1320

tagg                                                                1324


<210>  1891
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  1891

Met Lys Lys Asp Lys Lys Arg Asn Lys Ile Pro Ile Asp Asn Tyr Pro 
1               5                   10                  15


Ile Gln Thr Leu Val Asn Met Ser Leu Asn Pro Ser Arg Pro Ser Ser 
            20                  25                  30


Ser Glu Leu Val Glu Leu His Val Phe Tyr Val Pro Glu Gly Ser Trp 
        35                  40                  45


Asn Tyr Lys Leu Asn Thr Ile Ser Thr Glu Val Val Asn Lys Phe Ile 
    50                  55                  60


Ser Ala Gly Phe Leu Arg Gln Tyr Leu Leu Asn Leu Leu Tyr Glu Pro 
65                  70                  75                  80


<210>  1892
<211>  1537
<212>  DNA
<213>  Homo sapiens

<400>  1892
cgagcgcgag cctggaggag ggggaggaga aggggcggag cagtcggtgg gcgcggcggc     60

tgctggaggc tagcgcgacc cgactcttaa gttttctttt cctctccaga ggggccgatt    120

agggagagag accagaaatg agtggaatgc tatcttaagc caaaaaaaac tattataatt    180

tttatttagt actacttaaa tgaagaaaga taaaaaaaga aacaaaattc caattgataa    240

ttatcccatt cagacattag tgaatatgtc actcaatcca agtcgacctt cctcatcaga    300

gttggtggaa cttcatgttt tttatgtccc tgaaggatca tggaactata agctaaatac    360

catttcaaca gaagttgtta acaaattcat ttcagctgga tttctaaggc aatatctcct    420

caacttactt tacgagccct gagggagcgt cttggtgagt tcctgggtga agatgctatt    480

gcagaaaaat ttttatttct gaaatgcatt ggaaataatt tagctgtggt gaaggaaaag    540

caagaatcag aactgaaact caaatcattt gctcctccat atgctcttca accagaatta    600

tatttgcttc ctgtaatgga ccatttagga aatgtttatt caccatcaac agttatttta    660

gatgagcggc agactaataa tggtgttaat gaggctgatg gaacaatcca cagaccaatt    720

agtgtaactt tgttcaagga ggaacttgga agagatccca gtttgttaga aaacactttg    780

aaagagcttc ctaacaagaa tcaggaagaa gctgggggaa aagccactgc agaaaaaagc    840

caaattgcaa aaaatcaaat tggaaattct gagttgccag gatcattgga agattcaaat    900

aatgattgct ttggcactaa aaaaagtgtc tttgggaaaa tgaagatgat acagctatca    960

gtagaagaca ggacaatcag acagctgaaa aagagtacat caccctacca gatcaccctt   1020

cacttccttg tcaacctgtt ctttcttcag gaataactga tatatcttta ttacaaactg   1080

aaagagagaa gattatcaaa caaatgaaac aagtaaagga agaaagaagg tatctggaaa   1140

gaaatagaga agaactagta aaaacggttg aaaagctatt tgaacaaagc aaattaaaac   1200

gatatcatgc ctacaatggt tggaagaaaa aatacttgga aacaaagaaa gtcacagcat   1260

caatggagga ggttttaaca aaacttcgag aagatttgga actctactat aaaaaactgc   1320

tcatgcaact tgaagccagg gagatcaaga tgagaccaaa gaatctggca aacatcacag   1380

actccaagaa ttacctaata atccagatca ctgaggtaca gcatgcaatt gaccagctta   1440

agagaaaact agatactgac aaaatgaaac tcatagtaga agttaagatg agaaaacaag   1500

cagtttcaga tttacgaaca ttgaaaactg aactggc                            1537


<210>  1893
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  1893

Met Asp His Leu Gly Asn Val Tyr Ser Pro Ser Thr Val Ile Leu Asp 
1               5                   10                  15


Glu Arg Gln Thr Asn Asn Gly Val Asn Glu Ala Asp Gly Thr Ile His 
            20                  25                  30


Arg Pro Ile Ser Val Thr Leu Phe Lys Glu Glu Leu Gly Arg Asp Pro 
        35                  40                  45


Ser Leu Leu Glu Asn Thr Leu Lys Glu Leu Pro Asn Lys Asn Gln Glu 
    50                  55                  60


Glu Ala Gly Gly Lys Ala Thr Ala Glu Lys Ser Gln Ile Ala Lys Asn 
65                  70                  75                  80


Gln Ile Gly Asn Ser Glu Leu Pro Gly Ser Leu Glu Asp Ser Asn Asn 
                85                  90                  95


Asp Cys Phe Gly Thr Lys Lys Ser Val Phe Gly Lys Met Lys Met Ile 
            100                 105                 110


Gln Leu Ser Val Glu Asp Arg Thr Ile Arg Gln Leu Lys Lys Ser Thr 
        115                 120                 125


Ser Pro Tyr Gln Ile Thr Leu His Phe Leu Val Asn Leu Phe Phe Leu 
    130                 135                 140


Gln Glu 
145


<210>  1894
<211>  563
<212>  DNA
<213>  Homo sapiens

<400>  1894
gcctggagga gggggaggag aaggggcgga gcagtcggtg ggcgcggcgg ctgctggagg     60

ctagcgcgac ccgactctta agttttcttt tcctctccag aggggccgat tagggagagg    120

agattgtgaa gaagccaagg tgctggctga agattacacc tgtctgctcg gttacccatt    180

tactctggag aattaatgct tattgtactt tttaaaataa aacttatttt tgtgtttccg    240

gaaagtttgc tctttagtat ttccgttgta atttattacc tcctgcttga aattgagtac    300

caaaggagtt tttaggagag agggtagggt ctaaccaaac aaaataggct cagccagtag    360

gtctttcttt catccacgga aatatgtgtg ttatgtcaca gcactaaggg cagatgtttc    420

ctatttcttt tcgggtagtc aatctccgaa tgcgctgatg ttttccatta atgttaataa    480

ttttatcatt aatggatttc aaatttttta ttagggaagc atgtgtaatt gcactggtca    540

acaaaatcta atttatttac tca                                            563


<210>  1895
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  1895

Met Leu Ile Val Leu Phe Lys Ile Lys Leu Ile Phe Val Phe Pro Glu 
1               5                   10                  15


Ser Leu Leu Phe Ser Ile Ser Val Val Ile Tyr Tyr Leu Leu Leu Glu 
            20                  25                  30


Ile Glu Tyr Gln Arg Ser Phe 
        35


<210>  1896
<211>  374
<212>  DNA
<213>  Homo sapiens

<400>  1896
cctctccaga ggggccgatt agggagaggc gtgtctctct gtgacccgag tttggccaac     60

aggcattttc agttccaccc ccaaccccca gccccgctga cccgaggcgg agagcaggcg    120

cggaggtcgc tgtcgcgtac ccagcggagc cgggcgggcg gggagcaggg gcgctgattc    180

gctggagaag ggatcttctc gaggtttgac tttactggct tcttagctct tgaatcggtt    240

tttctgaagg agattgtgaa gaagccaagg tgctggctga agattacacc tgtctgctcg    300

gttacccatt tactctggag aattaatgct tattgtactt tttaaaataa aacttatttt    360

tgtgtttccg gaaa                                                      374


<210>  1897
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  1897

Pro Leu Gln Arg Gly Arg Leu Gly Arg Gly Val Ser Leu Cys Asp Pro 
1               5                   10                  15


Ser Leu Ala Asn Arg His Phe Gln Phe His Pro Gln Pro Pro Ala Pro 
            20                  25                  30


Leu Thr Arg Gly Gly Glu Gln Ala Arg Arg Ser Leu Ser Arg Thr Gln 
        35                  40                  45


Arg Ser Arg Ala Gly Gly Glu Gln Gly Arg 
    50                  55


<210>  1898
<211>  609
<212>  DNA
<213>  Homo sapiens

<400>  1898
aaaattagcc aggtgtggtg gtgcacgcct gtaatcccag ctactcggga ggctgaggct     60

ggagaatcgc ttgaacccga gaggcggagg ttgcagtgag ctgagatcac gccactgcac    120

tctagcctgg acaacagagt cagactctgt ctaaaaaaaa taaaataaaa ataaaattcc    180

tataatttaa cttttttatt gttgtagaac atattacata acaaactgta ccatttaaaa    240

tatttttaaa tggtacagtt cagtggcaca acattcacac tgttgtgaaa ccatcaccac    300

cacccatctc cagaacttat ttatcttctc aaactgaaac tctataccca ttaaacagta    360

actccccatt aacattattt actttacctc acagaatcat ctgtacttac gattgcacta    420

tacttacttt cagtttgtaa taaagatata tcagttattc ctgaagaaag aacaggttga    480

caaggaagtg aagggtgata aaacaatgaa acagatctat ttaaaattat aattttagaa    540

aacatccttg aaataaaaca atttctgatt tctgattttc atattgaaag ggcccactgt    600

gtacctaga                                                            609


<210>  1899
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  1899

Gln Thr Val Pro Phe Lys Ile Phe Leu Asn Gly Thr Val Gln Trp His 
1               5                   10                  15


Asn Ile His Thr Val Val Lys Pro Ser Pro Pro Pro Ile Ser Arg Thr 
            20                  25                  30


Tyr Leu Ser Ser Gln Thr Glu Thr Leu Tyr Pro Leu Asn Ser Asn Ser 
        35                  40                  45


Pro Leu Thr Leu Phe Thr Leu Pro His Arg Ile Ile Cys Thr Tyr Asp 
    50                  55                  60


Cys Thr Ile Leu Thr Phe Ser Leu 
65                  70


<210>  1900
<211>  1493
<212>  DNA
<213>  Homo sapiens

<400>  1900
acagctgaaa aagagtacat caccctacca gatcaccctt cacttccttg tcaacctgtt     60

ctttcttcag gaataactga tatatcttta ttacaaactg aaacctacaa tggttggaag    120

aaaaaatact tggaaacaaa gaaagtcaca gcatcaatgg aggaggtttt aacaaaactt    180

cgagaagatt tggaactcta ctataaaaaa ctgctcatgc aacttgaagc cagggagatc    240

aagatgagac caaagaatct ggcaaacatc acagactcca agatgagaaa acaagcagtt    300

tcagatttac gaacattgaa aactgaactg gcacagaaaa aaaaaataat acatctctac    360

aatctcaatt agttgctaga agtgtgcctg gctaggaggt ctacagaaga ttttgtttat    420

gatgaatcag ccaagtcaaa agggagcatt ggctgctgca atacattctg accagatctg    480

actttgttca tcataagaca tcacaaagag gaagtcacaa gcatctgcga ttccagtata    540

attatagcat cttctgtcta tgttctttgg agaccaagct acatcaaagg ttacctgtgg    600

aaaaaaatct tactatttta tgtaatatga tcacgtgtgc atattacgtc agatttttaa    660

aattatatat attttttacc ttatactaca caaggaaaag gaactgctta cagtatatga    720

atgtagggtt tgacacacat agaacttgaa ccattctaag aaatattttt tgcttacact    780

tgactgagtc agacatatat ttggacatac aatgaccagg agcaagacac tatatagaag    840

atggccttca aactcaaaat gtcttcaaac gctaggctgg tacctcagct gattaaaaga    900

agcaggtata atgacaacag ggtatggtga tgcccctgag caactagaga gtaaaggcac    960

actaaaagaa ttcaaataca aaagttttta aaatattgtg caggttaaat atgtcacctg   1020

ttggcacaac ctgactgggt tgggagtttc agcctgattc acaatcacct tatatggtag   1080

atttggccca atattacagt taagacaata gtggtgtctt acggcctaca ggtatagatt   1140

aatcaagtca aaatgttgaa taaatcattt aaatgatctt attttacgga aatattcaaa   1200

taaatgttga gtattatctt tcttttttgg gggggatgga gtcttgctct gtcacccagg   1260

gtggagtgca gtggcgcaat ctcagctcac tgcaacctct gcctcctggg ttcaagtgat   1320

tctcctgcct cagcctccca catagctggg attacaggca tgcgccacca cgcccagcta   1380

atttttttgt atttttagta gagacagggt tttgccatgt tgcccaggct ggtctcaaac   1440

tcctgacctc agctgatctg ccgatctcag cctcccaaag tgcttacagg cgt          1493


<210>  1901
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  1901

Met Glu Glu Val Leu Thr Lys Leu Arg Glu Asp Leu Glu Leu Tyr Tyr 
1               5                   10                  15


Lys Lys Leu Leu Met Gln Leu Glu Ala Arg Glu Ile Lys Met Arg Pro 
            20                  25                  30


Lys Asn Leu Ala Asn Ile Thr Asp Ser Lys Met Arg Lys Gln Ala Val 
        35                  40                  45


Ser Asp Leu Arg Thr Leu Lys Thr Glu Leu Ala Gln Lys Lys Lys Ile 
    50                  55                  60


Ile His Leu Tyr Asn Leu Asn 
65                  70


<210>  1902
<211>  1651
<212>  DNA
<213>  Homo sapiens

<400>  1902
acagagatga acatcttttg tcaaaccatt aagagttaga aagatgatct gtatcaacag     60

atctagtttc ttgcattttt attatgttgc tatatacttt tgttatccgt atactaaaaa    120

aaaagaataa ataaatgttt tgattgtttg aatttgaaaa atacacacga atgtcctcag    180

tatccaggaa cataaaggca agaagcaagt caacttacct attaaatatt cctctattag    240

atgtttcaac actataattt aattgggaaa aattgctttc agaattttat tatgccatat    300

ttcccttcat tatagtaaaa tatatgctca cgaatcaatg ctgattttta aaatatgtat    360

aatctgaagt ggaaattgtt tgcttagagt ttttaaaaac ctagtctttg aaaagcagtt    420

tgtgctatac ttttccccca accctccaat aaatcttaaa tttaaaacct acaatgtagt    480

gtctcccctt taggttcatc aaactgatga aaataatttt tctgcttcct gactccatat    540

agtatttatg ttctctgagg tacttgaact aaatctttgg acagtgagtg agaattaaaa    600

agaatccaga agattaaatg tattcacaaa atagaagaat gtaacagtaa tattttgaat    660

tgagacaggg tctcgctatg ttgtccagat gggtctccaa ctcctgggct caagcactcc    720

tcctgccttg gcttcctaaa gagctgggat tacaggcatg agctgcattg tgcttttaat    780

gatctaaaga cactgattag cttctcaact agttctcttt ctaaaagatc aattttatac    840

aaataagttt tctaaatgta ataaagtctg ttttctttct ccagggaatt aagaacaaca    900

ttgtgctgcc cttattagtt cctaattaca gattaaaaat ctgtatcttt gaactctaga    960

tttacataaa tcctggcttc cctgcacatt ttgcccctgt aaattggaat acatgatgat   1020

tgaaccatct gttatgagaa tattacattt cctatttaca caattgtttg tgacagagta   1080

aaaaccattt tcatagtata tgttggatca ctgttgtctt catatttcta aaataaatga   1140

attaaaaaat ttaaattctt agatgcttat ctctatcata gctcagaatg caacttcaat   1200

acccccattc ttttatattt ccagatttct tttaattaag atataatgaa caaattaagt   1260

taaatgaagt ctgtattttc atgcaaatat attagtattc attaatatac atttattctt   1320

tgcaaataga ttttagttat attagctctt aaattgttaa ataaattatt attgaatttt   1380

attattaaat tattaaaatg aaaattataa aattagcact gtaaaataat atgtaaagga   1440

cttggaatgt taaaaataac cattcatcat tttgctttat attacatcta atatttcctg   1500

aaacattttg taatacccac atggaaagtg gagaaagaga aaccttgtgc tttttataaa   1560

acattgccaa ggagaataat ggttaaacaa atctgttcaa atacatattt aaattttttt   1620

acaaataaaa gttttaaatt aacataccta a                                  1651


<210>  1903
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  1903

Asp Arg Val Ser Leu Cys Cys Pro Asp Gly Ser Pro Thr Pro Gly Leu 
1               5                   10                  15


Lys His Ser Ser Cys Leu Gly Phe Leu Lys Ser Trp Asp Tyr Arg His 
            20                  25                  30


Glu Leu His Cys Ala Phe Asn Asp Leu Lys Thr Leu Ile Ser Phe Ser 
        35                  40                  45


Thr Ser Ser Leu Ser Lys Arg Ser Ile Leu Tyr Lys 
    50                  55                  60


<210>  1904
<211>  3365
<212>  DNA
<213>  Homo sapiens

<400>  1904
gctgctatgt cccggccgca gcttcgacgc tggcgcctcg tctctagccc gccgagcggc     60

gtcccgggtc tagcgctgct ggcgctgctg gcgctgctgg cgctgcggct cgcggccggg    120

accgactgcc catgcccgga gcctgagctc tgccgcccga ttcgccacca tccagatttc    180

gaggtcagcg ccttcctctg ctcctctagg tctgggcttc agggcacgaa gagaagttag    240

ggtagaacgg agccctaagg agaggtgccg tgggcgccga aaccagcttt gaccactcga    300

tgagggcctt cctgtttacg gatccttcaa tttatagatg aggaagctcg ggctcagaga    360

agttgagtaa ctcctcaggc ctcacagcct gtaagtgcct gcgtaggcag gcgagagttc    420

aaaccagatc tgcctcctaa ggcaagctcc tttcattccc ctgctgtgcc tctgcggaag    480

cactctgggt gtaaaaagca aacaaggtct ttgtgtttga tgttggacag aaaacttgga    540

aatcttatga ttggtcacag attacaactg tggcaacatt tggaaaatat gactcagaac    600

ttatgtgcta cgctcattca aaaggagcca gagtagtact taaaggagat gtatccttaa    660

aggatatcat tgatcctgct ttcagagcat cctggatagc tcaaaaactt aatttggcca    720

aaacacaata tatggatgga attaatatag atatagagca agaagttaat tgtttatcac    780

ctgaatatga tgcattaact gctttagtca aagaaactac agactctttc catcgtgaaa    840

ttgagggatc acaggtaacc tttgatgtag cttggtctcc aaagaacata gacagaagat    900

gctataatta tactggaatc gcagatgctt gtgacttcct ctttgtgatg tcttatgatg    960

aacaaagtca gatctggtca gaatgtattg cagcagccaa tgctccctat aatcagacat   1020

taactggata taatgactac atcaagatga gcattaatcc taagaaactt gtaatgggtg   1080

ttccttggta tggttatgat tatacctgcc tgaatctgtc tgaggatcat gtttgtacca   1140

ttgcaaaagt ccctttccgg ggggctcctt gtagtgacgc tgcaggacgt caggtgccct   1200

acaaaacgat catgaagcaa ataaatagtt ctatttctgg aaacctatgg gataaagatc   1260

agcgggctcc ttattataac tataaagatc ctgctggcca ctttcatcaa gtatggtatg   1320

ataaccctca gagtatttct ttaaaggcaa catatataca aaactatcgc ttacggggca   1380

ttggcatgtg gaatgcaaac tgtcttgact actctggaga tgctgtagcc aaacagcaaa   1440

ctgaagaaat gtgggaagtc ttaaagccaa agctgttaca gagatgaaca tcttttgtca   1500

aaccattaag agttagaaag atgatctgta tcaacagatc tagtttcttg catttttatt   1560

atgttgctat atacttttgt tatccgtata ctaaaaaaaa agaataaata aatgttttga   1620

ttgtttgaat ttgaaaaata cacacgaatg tcctcagtat ccaggaacat aaaggcaaga   1680

agcaagtcaa cttacctatt aaatattcct ctattagatg tttcaacact ataatttaat   1740

tgggaaaaat tgctttcaga attttattat gccatatttc ccttcattat agtaaaatat   1800

atgctcacga atcaatgctg atttttaaaa tatgtataat ctgaagtgga aattgtttgc   1860

ttagagtttt taaaaaccta gtctttgaaa agcagtttgt gctatacttt tcccccaacc   1920

ctccaataaa tcttaaattt aaaacctaca atgtagtgtc tcccctttag gttcatcaaa   1980

ctgatgaaaa taatttttct gcttcctgac tccatatagt atttatgttc tctgaggtac   2040

ttgaactaaa tctttggaca gtgagtgaga attaaaaaga atccagaaga ttaaatgtat   2100

tcacaaaata gaagaatgta acagtaatat tttgaattgg taagttagaa ctacctaata   2160

ttttccaact acattatttt tatgaggctc atttgtaaaa tttttaataa taggaataac   2220

ttgcagttga acttgattct gttcactgtc acacttctaa ttattcattt cttcatttat   2280

ggacatatat aatttatttc ttggctagct tgcttacatg gttaaatttt tctttctaca   2340

tctgcaatgt atctttttta tttttatttt ttgtagagac agggtctcgc tatgttgtcc   2400

agatgggtct ccaactcctg ggctcaagca ctcctcctgc cttggcttcc taaagagctg   2460

ggattacagg catgagctgc attgtgcttt taatgatcta aagacactga ttagcttctc   2520

aactagttct ctttctaaaa gatcaatttt atacaaataa gttttctaaa tgtaataaag   2580

tctgttttct ttctccaggg aattaagaac aacattgtgc tgcccttatt agttcctaat   2640

tacagattaa aaatctgtat ctttgaactc tagatttaca taaatcctgg cttccctgca   2700

cattttgccc ctgtaaattg gaatacatga tgattgaacc atctgttatg agaatattac   2760

atttcctatt tacacaattg tttgtgacag agtaaaaacc attttcatag tatatgttgg   2820

atcactgttg tcttcatatt tctaaaataa atgaattaaa aaatttaaat tcttagatgc   2880

ttatctctat catagctcag aatgcaactt caataccccc attcttttat atttccagat   2940

ttcttttaat taagatataa tgaacaaatt aagttaaatg aagtctgtat tttcatgcaa   3000

atatattagt attcattaat atacatttat tctttgcaaa tagattttag ttatattagc   3060

tcttaaattg ttaaataaat tattattgaa ttttattatt aaattattaa aatgaaaatt   3120

ataaaattag cactgtaaaa taatatgtaa aggacttgga atgttaaaaa taaccattca   3180

tcattttgct ttatattaca tctaatattt cctgaaacat tttgtaatac ccacatggaa   3240

agtggagaaa gagaaacctt gtgcttttta taaaacattg ccaaggagaa taatggttaa   3300

acaaatctgt tcaaatacat atttaaattt ttttacaaat aaaagtttta aattaacata   3360

cctaa                                                               3365


<210>  1905
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  1905

Met Cys Tyr Ala His Ser Lys Gly Ala Arg Val Val Leu Lys Gly Asp 
1               5                   10                  15


Val Ser Leu Lys Asp Ile Ile Asp Pro Ala Phe Arg Ala Ser Trp Ile 
            20                  25                  30


Ala Gln Lys Leu Asn Leu Ala Lys Thr Gln Tyr Met Asp Gly Ile Asn 
        35                  40                  45


Ile Asp Ile Glu Gln Glu Val Asn Cys Leu Ser Pro Glu Tyr Asp Ala 
    50                  55                  60


Leu Thr Ala Leu Val Lys Glu Thr Thr Asp Ser Phe His Arg Glu Ile 
65                  70                  75                  80


Glu Gly Ser Gln Val Thr Phe Asp Val Ala Trp Ser Pro Lys Asn Ile 
                85                  90                  95


Asp Arg Arg Cys Tyr Asn Tyr Thr Gly Ile Ala Asp Ala Cys Asp Phe 
            100                 105                 110


Leu Phe Val Met Ser Tyr Asp Glu Gln Ser Gln Ile Trp Ser Glu Cys 
        115                 120                 125


Ile Ala Ala Ala Asn Ala Pro Tyr Asn Gln Thr Leu Thr Gly Tyr Asn 
    130                 135                 140


Asp Tyr Ile Lys Met Ser Ile Asn Pro Lys Lys Leu Val Met Gly Val 
145                 150                 155                 160


Pro Trp Tyr Gly Tyr Asp Tyr Thr Cys Leu Asn Leu Ser Glu Asp His 
                165                 170                 175


Val Cys Thr Ile Ala Lys Val Pro Phe Arg Gly Ala Pro Cys Ser Asp 
            180                 185                 190


Ala Ala Gly Arg Gln Val Pro Tyr Lys Thr Ile Met Lys Gln Ile Asn 
        195                 200                 205


Ser Ser Ile Ser Gly Asn Leu Trp Asp Lys Asp Gln Arg Ala Pro Tyr 
    210                 215                 220


Tyr Asn Tyr Lys Asp Pro Ala Gly His Phe His Gln Val Trp Tyr Asp 
225                 230                 235                 240


Asn Pro Gln Ser Ile Ser Leu Lys Ala Thr Tyr Ile Gln Asn Tyr Arg 
                245                 250                 255


Leu Arg Gly Ile Gly Met Trp Asn Ala Asn Cys Leu Asp Tyr Ser Gly 
            260                 265                 270


Asp Ala Val Ala Lys Gln Gln Thr Glu Glu Met Trp Glu Val Leu Lys 
        275                 280                 285


Pro Lys Leu Leu Gln Arg 
    290


<210>  1906
<211>  3165
<212>  DNA
<213>  Homo sapiens

<400>  1906
gctagacctg ctgctatgtc ccggccgcag cttcgacgct ggcgcctcgt ctctagcccg     60

ccgagcggcg tcccgggtct agcgctgctg gcgctgctgg cgctgctggc gctgcggctc    120

gcggccggga ccgactgccc atgcccggag cctgagctct gccgcccgat tcgccaccat    180

ccagatttcg aggtcagcgc cttcctctgc tcctctaggt ctgggcttca gggcacgaag    240

agaagttagg gtagaacgga gccctaagga gaggtgccgt gggcgccgaa accagctttg    300

accactcgat gagggccttc ctgtttacgg atccttcaat ttatagatga ggaagctcgg    360

gctcagagaa gttgagtaac tcctcaggcc tcacagcctg taagtgcctg cgtaggcagg    420

cgagagttca aaccagatct gcctcctaag gcaagctcct ttcattcccc tgctgtgcct    480

ctgcggaagc actctgggtg taaaaagcaa acaaggtctt tgtgtttgat gttggacaga    540

aaacttggaa atcttatgat tggtcacaga ttacaactgt ggcaacattt ggaaaatatg    600

actcagaact tatgtgctac gctcattcaa aaggagccag agtagtactt aaaggtaacc    660

tttgatgtag cttggtctcc aaagaacata gacagaagat gctataatta tactggaatc    720

gcagatgctt gtgacttcct ctttgtgatg tcttatgatg aacaaagtca gatctggtca    780

gaatgtattg cagcagccaa tgctccctat aatcagacat taactggata taatgactac    840

atcaagatga gcattaatcc taagaaactt gtaatgggtg ttccttggta tggttatgat    900

tatacctgcc tgaatctgtc tgaggatcat gtttgtacca ttgcaaaagt ccctttccgg    960

ggggctcctt gtagtgacgc tgcaggacgt caggtgccct acaaaacgat catgaagcaa   1020

ataaatagtt ctatttctgg aaacctatgg gataaagatc agcgggctcc ttattataac   1080

tataaagatc ctgctggcca ctttcatcaa gtatggtatg ataaccctca gagtatttct   1140

ttaaaggcaa catatataca aaactatcgc ttacggggca ttggcatgtg gaatgcaaac   1200

tgtcttgact actctggaga tgctgtagcc aaacagcaaa ctgaagaaat gtgggaagtc   1260

ttaaagccaa agctgttaca gagatgaaca tcttttgtca aaccattaag agttagaaag   1320

atgatctgta tcaacagatc tagtttcttg catttttatt atgttgctat atacttttgt   1380

tatccgtata ctaaaaaaaa agaataaata aatgttttga ttgtttgaat ttgaaaaata   1440

cacacgaatg tcctcagtat ccaggaacat aaaggcaaga agcaagtcaa cttacctatt   1500

aaatattcct ctattagatg tttcaacact ataatttaat tgggaaaaat tgctttcaga   1560

attttattat gccatatttc ccttcattat agtaaaatat atgctcacga atcaatgctg   1620

atttttaaaa tatgtataat ctgaagtgga aattgtttgc ttagagtttt taaaaaccta   1680

gtctttgaaa agcagtttgt gctatacttt tcccccaacc ctccaataaa tcttaaattt   1740

aaaacctaca atgtagtgtc tcccctttag gttcatcaaa ctgatgaaaa taatttttct   1800

gcttcctgac tccatatagt atttatgttc tctgaggtac ttgaactaaa tctttggaca   1860

gtgagtgaga attaaaaaga atccagaaga ttaaatgtat tcacaaaata gaagaatgta   1920

acagtaatat tttgaattgg taagttagaa ctacctaata ttttccaact acattatttt   1980

tatgaggctc atttgtaaaa tttttaataa taggaataac ttgcagttga acttgattct   2040

gttcactgtc acacttctaa ttattcattt cttcatttat ggacatatat aatttatttc   2100

ttggctagct tgcttacatg gttaaatttt tctttctaca tctgcaatgt atctttttta   2160

tttttatttt ttgtagagac agggtctcgc tatgttgtcc agatgggtct ccaactcctg   2220

ggctcaagca ctcctcctgc cttggcttcc taaagagctg ggattacagg catgagctgc   2280

attgtgcttt taatgatcta aagacactga ttagcttctc aactagttct ctttctaaaa   2340

gatcaatttt atacaaataa gttttctaaa tgtaataaag tctgttttct ttctccaggg   2400

aattaagaac aacattgtgc tgcccttatt agttcctaat tacagattaa aaatctgtat   2460

ctttgaactc tagatttaca taaatcctgg cttccctgca cattttgccc ctgtaaattg   2520

gaatacatga tgattgaacc atctgttatg agaatattac atttcctatt tacacaattg   2580

tttgtgacag agtaaaaacc attttcatag tatatgttgg atcactgttg tcttcatatt   2640

tctaaaataa atgaattaaa aaatttaaat tcttagatgc ttatctctat catagctcag   2700

aatgcaactt caataccccc attcttttat atttccagat ttcttttaat taagatataa   2760

tgaacaaatt aagttaaatg aagtctgtat tttcatgcaa atatattagt attcattaat   2820

atacatttat tctttgcaaa tagattttag ttatattagc tcttaaattg ttaaataaat   2880

tattattgaa ttttattatt aaattattaa aatgaaaatt ataaaattag cactgtaaaa   2940

taatatgtaa aggacttgga atgttaaaaa taaccattca tcattttgct ttatattaca   3000

tctaatattt cctgaaacat tttgtaatac ccacatggaa agtggagaaa gagaaacctt   3060

gtgcttttta taaaacattg ccaaggagaa taatggttaa acaaatctgt tcaaatacat   3120

atttaaattt ttttacaaat aaaagtttta aattaacata cctaa                   3165


<210>  1907
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  1907

Met Ser Tyr Asp Glu Gln Ser Gln Ile Trp Ser Glu Cys Ile Ala Ala 
1               5                   10                  15


Ala Asn Ala Pro Tyr Asn Gln Thr Leu Thr Gly Tyr Asn Asp Tyr Ile 
            20                  25                  30


Lys Met Ser Ile Asn Pro Lys Lys Leu Val Met Gly Val Pro Trp Tyr 
        35                  40                  45


Gly Tyr Asp Tyr Thr Cys Leu Asn Leu Ser Glu Asp His Val Cys Thr 
    50                  55                  60


Ile Ala Lys Val Pro Phe Arg Gly Ala Pro Cys Ser Asp Ala Ala Gly 
65                  70                  75                  80


Arg Gln Val Pro Tyr Lys Thr Ile Met Lys Gln Ile Asn Ser Ser Ile 
                85                  90                  95


Ser Gly Asn Leu Trp Asp Lys Asp Gln Arg Ala Pro Tyr Tyr Asn Tyr 
            100                 105                 110


Lys Asp Pro Ala Gly His Phe His Gln Val Trp Tyr Asp Asn Pro Gln 
        115                 120                 125


Ser Ile Ser Leu Lys Ala Thr Tyr Ile Gln Asn Tyr Arg Leu Arg Gly 
    130                 135                 140


Ile Gly Met Trp Asn Ala Asn Cys Leu Asp Tyr Ser Gly Asp Ala Val 
145                 150                 155                 160


Ala Lys Gln Gln Thr Glu Glu Met Trp Glu Val Leu Lys Pro Lys Leu 
                165                 170                 175


Leu Gln Arg 



<210>  1908
<211>  3091
<212>  DNA
<213>  Homo sapiens

<400>  1908
aggccccgcc cacccaggcg gtaggaaccc actccggccc gctagacctg ctgctatgtc     60

ccggccgcag cttcgacgct ggcgcctcgt ctctagcccg ccgagcggcg tcccgggtct    120

agcgctgctg gcgctgctgg cgctgctggc gctgcggctc gcggccggga ccgactgccc    180

atgcccggag cctgagctct gccgcccgat tcgccaccat ccagatttcg aggtctttgt    240

gtttgatgtt ggacagaaaa cttggaaatc ttatgattgg tcacagatta caactgtggc    300

aacatttgga aaatatgact cagaacttat gtgctacgct cattcaaaag gagccagagt    360

agtacttaaa ggagatgtat ccttaaagga tatcattgat cctgctttca gagcatcctg    420

gatagctcaa aaacttaatt tggccaaaac acaatatatg gatggaatta atatagatat    480

agagcaagaa gttaattgtt tatcacctga atatgatgca ttaactgctt tagtcaaaga    540

aactacagac tctttccatc gtgaaattga gggatcacag gtaacctttg atgtagcttg    600

gtctccaaag aacatagaca gaagatgcta taattatact ggaatcgcag atgcttgtga    660

cttcctcttt gtgatgtctt atgatgaaca aagtcagatc tggtcagaat gtattgcagc    720

agccaatgct ccctataatc agacattaac tggatataat gactacatca agatgagcat    780

taatcctaag aaacttgtaa tgggtgttcc ttggtatggt tatgattata cctgcctgaa    840

tctgtctgag gatcatgttt gtaccattgc aaaagtccct ttccgggggg ctccttgtag    900

tgacgctgca ggacgtcagg tgccctacaa aacgatcatg aagcaaataa atagttctat    960

ttctggaaac ctatgggata aagatcagcg ggctccttat tataactata aagatcctgc   1020

tggccacttt catcaagtat ggtatgataa ccctcagagt atttctttaa aggcaacata   1080

tatacaaaac tatcgcttac ggggcattgg catgtggaat gcaaactgtc ttgactactc   1140

tggagatgct gtagccaaac agcaaactga agaaatgtgg gaagtcttaa agccaaagct   1200

gttacagaga tgaacatctt ttgtcaaacc attaagagtt agaaagatga tctgtatcaa   1260

cagatctagt ttcttgcatt tttattatgt tgctatatac ttttgttatc cgtatactaa   1320

aaaaaaagaa taaataaatg ttttgattgt ttgaatttga aaaatacaca cgaatgtcct   1380

cagtatccag gaacataaag gcaagaagca agtcaactta cctattaaat attcctctat   1440

tagatgtttc aacactataa tttaattggg aaaaattgct ttcagaattt tattatgcca   1500

tatttccctt cattatagta aaatatatgc tcacgaatca atgctgattt ttaaaatatg   1560

tataatctga agtggaaatt gtttgcttag agtttttaaa aacctagtct ttgaaaagca   1620

gtttgtgcta tacttttccc ccaaccctcc aataaatctt aaatttaaaa cctacaatgt   1680

agtgtctccc ctttaggttc atcaaactga tgaaaataat ttttctgctt cctgactcca   1740

tatagtattt atgttctctg aggtacttga actaaatctt tggacagtga gtgagaatta   1800

aaaagaatcc agaagattaa atgtattcac aaaatagaag aatgtaacag taatattttg   1860

aattggtaag ttagaactac ctaatatttt ccaactacat tatttttatg aggctcattt   1920

gtaaaatttt taataatagg aataacttgc agttgaactt gattctgttc actgtcacac   1980

ttctaattat tcatttcttc atttatggac atatataatt tatttcttgg ctagcttgct   2040

tacatggtta aatttttctt tctacatctg caatgtatct tttttatttt tattttttgt   2100

agagacaggg tctcgctatg ttgtccagat gggtctccaa ctcctgggct caagcactcc   2160

tcctgccttg gcttcctaaa gagctgggat tacaggcatg agctgcattg tgcttttaat   2220

gatctaaaga cactgattag cttctcaact agttctcttt ctaaaagatc aattttatac   2280

aaataagttt tctaaatgta ataaagtctg ttttctttct ccagggaatt aagaacaaca   2340

ttgtgctgcc cttattagtt cctaattaca gattaaaaat ctgtatcttt gaactctaga   2400

tttacataaa tcctggcttc cctgcacatt ttgcccctgt aaattggaat acatgatgat   2460

tgaaccatct gttatgagaa tattacattt cctatttaca caattgtttg tgacagagta   2520

aaaaccattt tcatagtata tgttggatca ctgttgtctt catatttcta aaataaatga   2580

attaaaaaat ttaaattctt agatgcttat ctctatcata gctcagaatg caacttcaat   2640

acccccattc ttttatattt ccagatttct tttaattaag atataatgaa caaattaagt   2700

taaatgaagt ctgtattttc atgcaaatat attagtattc attaatatac atttattctt   2760

tgcaaataga ttttagttat attagctctt aaattgttaa ataaattatt attgaatttt   2820

attattaaat tattaaaatg aaaattataa aattagcact gtaaaataat atgtaaagga   2880

cttggaatgt taaaaataac cattcatcat tttgctttat attacatcta atatttcctg   2940

aaacattttg taatacccac atggaaagtg gagaaagaga aaccttgtgc tttttataaa   3000

acattgccaa ggagaataat ggttaaacaa atctgttcaa atacatattt aaattttttt   3060

acaaataaaa gttttaaatt aacataccta a                                  3091


<210>  1909
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  1909

Met Ser Arg Pro Gln Leu Arg Arg Trp Arg Leu Val Ser Ser Pro Pro 
1               5                   10                  15


Ser Gly Val Pro Gly Leu Ala Leu Leu Ala Leu Leu Ala Leu Leu Ala 
            20                  25                  30


Leu Arg Leu Ala Ala Gly Thr Asp Cys Pro Cys Pro Glu Pro Glu Leu 
        35                  40                  45


Cys Arg Pro Ile Arg His His Pro Asp Phe Glu Val Phe Val Phe Asp 
    50                  55                  60


Val Gly Gln Lys Thr Trp Lys Ser Tyr Asp Trp Ser Gln Ile Thr Thr 
65                  70                  75                  80


Val Ala Thr Phe Gly Lys Tyr Asp Ser Glu Leu Met Cys Tyr Ala His 
                85                  90                  95


Ser Lys Gly Ala Arg Val Val Leu Lys Gly Asp Val Ser Leu Lys Asp 
            100                 105                 110


Ile Ile Asp Pro Ala Phe Arg Ala Ser Trp Ile Ala Gln Lys Leu Asn 
        115                 120                 125


Leu Ala Lys Thr Gln Tyr Met Asp Gly Ile Asn Ile Asp Ile Glu Gln 
    130                 135                 140


Glu Val Asn Cys Leu Ser Pro Glu Tyr Asp Ala Leu Thr Ala Leu Val 
145                 150                 155                 160


Lys Glu Thr Thr Asp Ser Phe His Arg Glu Ile Glu Gly Ser Gln Val 
                165                 170                 175


Thr Phe Asp Val Ala Trp Ser Pro Lys Asn Ile Asp Arg Arg Cys Tyr 
            180                 185                 190


Asn Tyr Thr Gly Ile Ala Asp Ala Cys Asp Phe Leu Phe Val Met Ser 
        195                 200                 205


Tyr Asp Glu Gln Ser Gln Ile Trp Ser Glu Cys Ile Ala Ala Ala Asn 
    210                 215                 220


Ala Pro Tyr Asn Gln Thr Leu Thr Gly Tyr Asn Asp Tyr Ile Lys Met 
225                 230                 235                 240


Ser Ile Asn Pro Lys Lys Leu Val Met Gly Val Pro Trp Tyr Gly Tyr 
                245                 250                 255


Asp Tyr Thr Cys Leu Asn Leu Ser Glu Asp His Val Cys Thr Ile Ala 
            260                 265                 270


Lys Val Pro Phe Arg Gly Ala Pro Cys Ser Asp Ala Ala Gly Arg Gln 
        275                 280                 285


Val Pro Tyr Lys Thr Ile Met Lys Gln Ile Asn Ser Ser Ile Ser Gly 
    290                 295                 300


Asn Leu Trp Asp Lys Asp Gln Arg Ala Pro Tyr Tyr Asn Tyr Lys Asp 
305                 310                 315                 320


Pro Ala Gly His Phe His Gln Val Trp Tyr Asp Asn Pro Gln Ser Ile 
                325                 330                 335


Ser Leu Lys Ala Thr Tyr Ile Gln Asn Tyr Arg Leu Arg Gly Ile Gly 
            340                 345                 350


Met Trp Asn Ala Asn Cys Leu Asp Tyr Ser Gly Asp Ala Val Ala Lys 
        355                 360                 365


Gln Gln Thr Glu Glu Met Trp Glu Val Leu Lys Pro Lys Leu Leu Gln 
    370                 375                 380


Arg 
385


<210>  1910
<211>  2892
<212>  DNA
<213>  Homo sapiens

<400>  1910
gacgcgcagc aggccccgcc cacccaggcg gtaggaaccc actccggccc gctagacctg     60

ctgctatgtc ccggccgcag cttcgacgct ggcgcctcgt ctctagcccg ccgagcggcg    120

tcccgggtct agcgctgctg gcgctgctgg cgctgctggc gctgcggctc gcggccggga    180

ccgactgccc atgcccggag cctgagctct gccgcccgat tcgccaccat ccagatttcg    240

aggtctttgt gtttgatgtt ggacagaaaa cttggaaatc ttatgattgg tcacagatta    300

caactgtggc aacatttgga aaatatgact cagaacttat gtgctacgct cattcaaaag    360

gagccagagt agtacttaaa ggtaaccttt gatgtagctt ggtctccaaa gaacatagac    420

agaagatgct ataattatac tggaatcgca gatgcttgtg acttcctctt tgtgatgtct    480

tatgatgaac aaagtcagat ctggtcagaa tgtattgcag cagccaatgc tccctataat    540

cagacattaa ctggatataa tgactacatc aagatgagca ttaatcctaa gaaacttgta    600

atgggtgttc cttggtatgg ttatgattat acctgcctga atctgtctga ggatcatgtt    660

tgtaccattg caaaagtccc tttccggggg gctccttgta gtgacgctgc aggacgtcag    720

gtgccctaca aaacgatcat gaagcaaata aatagttcta tttctggaaa cctatgggat    780

aaagatcagc gggctcctta ttataactat aaagatcctg ctggccactt tcatcaagta    840

tggtatgata accctcagag tatttcttta aaggcaacat atatacaaaa ctatcgctta    900

cggggcattg gcatgtggaa tgcaaactgt cttgactact ctggagatgc tgtagccaaa    960

cagcaaactg aagaaatgtg ggaagtctta aagccaaagc tgttacagag atgaacatct   1020

tttgtcaaac cattaagagt tagaaagatg atctgtatca acagatctag tttcttgcat   1080

ttttattatg ttgctatata cttttgttat ccgtatacta aaaaaaaaga ataaataaat   1140

gttttgattg tttgaatttg aaaaatacac acgaatgtcc tcagtatcca ggaacataaa   1200

ggcaagaagc aagtcaactt acctattaaa tattcctcta ttagatgttt caacactata   1260

atttaattgg gaaaaattgc tttcagaatt ttattatgcc atatttccct tcattatagt   1320

aaaatatatg ctcacgaatc aatgctgatt tttaaaatat gtataatctg aagtggaaat   1380

tgtttgctta gagtttttaa aaacctagtc tttgaaaagc agtttgtgct atacttttcc   1440

cccaaccctc caataaatct taaatttaaa acctacaatg tagtgtctcc cctttaggtt   1500

catcaaactg atgaaaataa tttttctgct tcctgactcc atatagtatt tatgttctct   1560

gaggtacttg aactaaatct ttggacagtg agtgagaatt aaaaagaatc cagaagatta   1620

aatgtattca caaaatagaa gaatgtaaca gtaatatttt gaattggtaa gttagaacta   1680

cctaatattt tccaactaca ttatttttat gaggctcatt tgtaaaattt ttaataatag   1740

gaataacttg cagttgaact tgattctgtt cactgtcaca cttctaatta ttcatttctt   1800

catttatgga catatataat ttatttcttg gctagcttgc ttacatggtt aaatttttct   1860

ttctacatct gcaatgtatc ttttttattt ttattttttg tagagacagg gtctcgctat   1920

gttgtccaga tgggtctcca actcctgggc tcaagcactc ctcctgcctt ggcttcctaa   1980

agagctggga ttacaggcat gagctgcatt gtgcttttaa tgatctaaag acactgatta   2040

gcttctcaac tagttctctt tctaaaagat caattttata caaataagtt ttctaaatgt   2100

aataaagtct gttttctttc tccagggaat taagaacaac attgtgctgc ccttattagt   2160

tcctaattac agattaaaaa tctgtatctt tgaactctag atttacataa atcctggctt   2220

ccctgcacat tttgcccctg taaattggaa tacatgatga ttgaaccatc tgttatgaga   2280

atattacatt tcctatttac acaattgttt gtgacagagt aaaaaccatt ttcatagtat   2340

atgttggatc actgttgtct tcatatttct aaaataaatg aattaaaaaa tttaaattct   2400

tagatgctta tctctatcat agctcagaat gcaacttcaa tacccccatt cttttatatt   2460

tccagatttc ttttaattaa gatataatga acaaattaag ttaaatgaag tctgtatttt   2520

catgcaaata tattagtatt cattaatata catttattct ttgcaaatag attttagtta   2580

tattagctct taaattgtta aataaattat tattgaattt tattattaaa ttattaaaat   2640

gaaaattata aaattagcac tgtaaaataa tatgtaaagg acttggaatg ttaaaaataa   2700

ccattcatca ttttgcttta tattacatct aatatttcct gaaacatttt gtaataccca   2760

catggaaagt ggagaaagag aaaccttgtg ctttttataa aacattgcca aggagaataa   2820

tggttaaaca aatctgttca aatacatatt taaatttttt tacaaataaa agttttaaat   2880

taacatacct aa                                                       2892


<210>  1911
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  1911

Met Ser Tyr Asp Glu Gln Ser Gln Ile Trp Ser Glu Cys Ile Ala Ala 
1               5                   10                  15


Ala Asn Ala Pro Tyr Asn Gln Thr Leu Thr Gly Tyr Asn Asp Tyr Ile 
            20                  25                  30


Lys Met Ser Ile Asn Pro Lys Lys Leu Val Met Gly Val Pro Trp Tyr 
        35                  40                  45


Gly Tyr Asp Tyr Thr Cys Leu Asn Leu Ser Glu Asp His Val Cys Thr 
    50                  55                  60


Ile Ala Lys Val Pro Phe Arg Gly Ala Pro Cys Ser Asp Ala Ala Gly 
65                  70                  75                  80


Arg Gln Val Pro Tyr Lys Thr Ile Met Lys Gln Ile Asn Ser Ser Ile 
                85                  90                  95


Ser Gly Asn Leu Trp Asp Lys Asp Gln Arg Ala Pro Tyr Tyr Asn Tyr 
            100                 105                 110


Lys Asp Pro Ala Gly His Phe His Gln Val Trp Tyr Asp Asn Pro Gln 
        115                 120                 125


Ser Ile Ser Leu Lys Ala Thr Tyr Ile Gln Asn Tyr Arg Leu Arg Gly 
    130                 135                 140


Ile Gly Met Trp Asn Ala Asn Cys Leu Asp Tyr Ser Gly Asp Ala Val 
145                 150                 155                 160


Ala Lys Gln Gln Thr Glu Glu Met Trp Glu Val Leu Lys Pro Lys Leu 
                165                 170                 175


Leu Gln Arg 



<210>  1912
<211>  1633
<212>  DNA
<213>  Homo sapiens

<400>  1912
gctgctatgt cccggccgca gcttcgacgc tggcgcctcg tctctagccc gccgagcggc     60

gtcccgggtc tagcgctgct ggcgctgctg gcgctgctgg cgctgcggct cgcggccggg    120

accgactgcc catgcccgga gcctgagctc tgccgcccga ttcgccacca tccagatttc    180

gaggtcagcg ccttcctctg ctcctctagg tctgggcttc agggcacgaa gagaagttag    240

ggtagaacgg agccctaagg agaggtgccg tgggcgccga aaccagcttt gaccactcga    300

tgagggcctt cctgtttacg gatccttcaa tttatagatg aggaagctcg ggctcagaga    360

agttgagtaa ctcctcaggc ctcacagcct gtaagtgcct gcgtaggcag gcgagagttc    420

aaaccagatc tgcctcctaa ggcaagctcc tttcattccc ctgctgtgcc tctgcggaag    480

cactctgggt gtaaaaagca aacaaggtct ttgtgtttga tgttggacag aaaacttgga    540

aatcttatga ttggtcacag attacaactg tggcaacatt tggaaaatat gactcagaac    600

ttatgtgcta cgctcattca aaaggagcca gagtagtact taaaggagat gtatccttaa    660

aggatatcat tgatcctgct ttcagagcat cctggatagc tcaaaaactt aatttggcca    720

aaacacaata tatggatgga attaatatag atatagagca agaagttaat tgtttatcac    780

ctgaatatga tgcattaact gctttagtca aagaaactac agactctttc catcgtgaaa    840

ttgagggatc acaggtaacc tttgatgtag cttggtctcc aaagaacata gacagaagat    900

gctataatta tactggaatc gcagatgctt gtgacttcct ctttgtgatg tcttatgatg    960

aacaaagtca gatctggtca gaatgtattg cagcagccaa tgctccctat aatcagacat   1020

taactggata taatgactac atcaagatga gcattaatcc taagaaactt gtaatgggtg   1080

ttccttggta tggttatgat tatacctgcc tgaatctgtc tgaggatcat gtttgtacca   1140

ttgcaaaagt ccctttccgg ggggctcctt gtagtgacgc tgcaggacgt caggtgccct   1200

acaaaacgat catgaagcaa ataaatagtt ctatttctgg aaacctatgg gataaagatc   1260

agcgggctcc ttattataac tataaagatc ctgctggcca ctttcatcaa gtatggtatg   1320

ataaccctca gagtatttct ttaaaggcaa catatataca aaactatcgc ttacggggca   1380

ttggcatgtg gaatgcaaac tgtcttgact actctggaga tgctgtagcc aaacagcaaa   1440

ctgaagaaat gtgggaagtc ttaaagccaa agctgttaca gagatgaaca tcttttgtca   1500

aaccattaag agttagaaag atgatctgta tcaacagatc tagtttcttg catttttatt   1560

atgttgctat atacttttgt tatccgtata ctaaaaaaaa agaataaata aatgttttga   1620

ttgtttgaat ttg                                                      1633


<210>  1913
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  1913

Met Cys Tyr Ala His Ser Lys Gly Ala Arg Val Val Leu Lys Gly Asp 
1               5                   10                  15


Val Ser Leu Lys Asp Ile Ile Asp Pro Ala Phe Arg Ala Ser Trp Ile 
            20                  25                  30


Ala Gln Lys Leu Asn Leu Ala Lys Thr Gln Tyr Met Asp Gly Ile Asn 
        35                  40                  45


Ile Asp Ile Glu Gln Glu Val Asn Cys Leu Ser Pro Glu Tyr Asp Ala 
    50                  55                  60


Leu Thr Ala Leu Val Lys Glu Thr Thr Asp Ser Phe His Arg Glu Ile 
65                  70                  75                  80


Glu Gly Ser Gln Val Thr Phe Asp Val Ala Trp Ser Pro Lys Asn Ile 
                85                  90                  95


Asp Arg Arg Cys Tyr Asn Tyr Thr Gly Ile Ala Asp Ala Cys Asp Phe 
            100                 105                 110


Leu Phe Val Met Ser Tyr Asp Glu Gln Ser Gln Ile Trp Ser Glu Cys 
        115                 120                 125


Ile Ala Ala Ala Asn Ala Pro Tyr Asn Gln Thr Leu Thr Gly Tyr Asn 
    130                 135                 140


Asp Tyr Ile Lys Met Ser Ile Asn Pro Lys Lys Leu Val Met Gly Val 
145                 150                 155                 160


Pro Trp Tyr Gly Tyr Asp Tyr Thr Cys Leu Asn Leu Ser Glu Asp His 
                165                 170                 175


Val Cys Thr Ile Ala Lys Val Pro Phe Arg Gly Ala Pro Cys Ser Asp 
            180                 185                 190


Ala Ala Gly Arg Gln Val Pro Tyr Lys Thr Ile Met Lys Gln Ile Asn 
        195                 200                 205


Ser Ser Ile Ser Gly Asn Leu Trp Asp Lys Asp Gln Arg Ala Pro Tyr 
    210                 215                 220


Tyr Asn Tyr Lys Asp Pro Ala Gly His Phe His Gln Val Trp Tyr Asp 
225                 230                 235                 240


Asn Pro Gln Ser Ile Ser Leu Lys Ala Thr Tyr Ile Gln Asn Tyr Arg 
                245                 250                 255


Leu Arg Gly Ile Gly Met Trp Asn Ala Asn Cys Leu Asp Tyr Ser Gly 
            260                 265                 270


Asp Ala Val Ala Lys Gln Gln Thr Glu Glu Met Trp Glu Val Leu Lys 
        275                 280                 285


Pro Lys Leu Leu Gln Arg 
    290


<210>  1914
<211>  1994
<212>  DNA
<213>  Homo sapiens

<400>  1914
gagaattact ctggattgta agcaaatatc tctggaagaa agggaaaact aagtcagagc     60

agaaggagaa ttgaaatggt gatgaggact gtggaagatg aaggcttgga actgagaccc    120

cctggaaaag acaggcactt gaaagcctat tgcctcaaag aaaagaagga tgtatcctct    180

atccagcaag cctttttcaa taaaatcatt atgtactcca cctgcaacaa ggaaagaaaa    240

caaagttccg tgaataacta aatcatcata atgaagcaaa acgataagca gaaagcaaga    300

gtgttttgaa agcattgatc acaatagcca agaaatgaag caatccagta tccatcgata    360

aatggatgga taaagaaaat gtggtacata catacaacgg aatattattc agccttaaca    420

atgaaggaca tccggacaca tgctacaaca tgaatggact ttgaagacat tatgttaaaa    480

gcaataagca aatcacaata gacaaatact atatgacata tgattccact tatatcaggt    540

acttagagta gtcacattca taaagacaga aagtagaatg gtggtttctc cggggaaggg    600

aaagagagac tagggagctg ttgtttaatt tgtgaaatca aaagaatttt gaagattgct    660

tgcataacat tgtgaatata tgaacactac tgaactatgt gctttaaaat ggttaagtta    720

gtaatgaact atatgcttaa aaatggttaa gatagtaaat tctgttattt tactgatgtt    780

tttttctctt tcaagtttta ttttagaatc aaggggaaca tacacaggtt tgttacaaaa    840

gtatattgtt tgatgctgag gtttgaggta tgattgaatc tgtcacccca ttagtcagca    900

cagtactgaa taggtagttc ttcggccttc acgacagttt ttttaaaagt acacaaacaa    960

ttgtaggtat ttaatttgtt actgtgcaca tgaatatact aaacaggaaa aggtcactaa   1020

gctgtggata tacacattgt ttacagttca atgagaattg gcttctgttg gctagcaata   1080

aatgtcaaac tgttcaacat tgattaatca tgaaggaata ttgcttaaca aagaataaaa   1140

tatctttctg aggttacaag caacaactag ctttctctga cttactgatt gacatgatgc   1200

aaaatgcctt cccagcctca gcatctgact tatatgatat tctagtcact tacaaagatg   1260

acaactgtat tagtccactt tcatgctgct gataaagaca tacctaagac cggccaactt   1320

acaaaagaaa gagctttatt ggacttacag ttccatgtgg ctggagaagc cactcagtgg   1380

cagaaggaca agatttcagg cacatctcac atggtggaag acgagagaag agagcttgtg   1440

tagggaaact cctgttttta aaaccatcaa atctcttgag acttattcac taccacgaga   1500

gcagcatgga aaagacctgc tcccatgatt caattacctc ccactgggtc cctctcacaa   1560

cacatggaaa ttcaagatga catttgagtg gggacacagc caaaccatat caacaacagt   1620

cttccagata ctaggtaaag aaaatctgac ccagtttgtt aaggtatgtt tactccttta   1680

tcttacctta ttggaggtaa gataaaagat aggtaagatc ttaccttaag atcaggaagg   1740

gtggttcata taataccagt atggcttcca attggtatac ccttgtggat ctgagggaag   1800

aaataagaat gtctgcccca taagaagcta ggagacagat tttggagtcc ctgagtccct   1860

gagaccctga cttggttaca acagccagag agaactgtgg gaatccctga gatggcagcc   1920

tcatcttaaa gggtgattac tagagataat aagggggaga agccttggtg agcatcctgg   1980

accattttgg ttcc                                                     1994


<210>  1915
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  1915

Met Val Met Arg Thr Val Glu Asp Glu Gly Leu Glu Leu Arg Pro Pro 
1               5                   10                  15


Gly Lys Asp Arg His Leu Lys Ala Tyr Cys Leu Lys Glu Lys Lys Asp 
            20                  25                  30


Val Ser Ser Ile Gln Gln Ala Phe Phe Asn Lys Ile Ile Met Tyr Ser 
        35                  40                  45


Thr Cys Asn Lys Glu Arg Lys Gln Ser Ser Val Asn Asn 
    50                  55                  60


<210>  1916
<211>  1728
<212>  DNA
<213>  Homo sapiens

<400>  1916
agagtgacat tgtttgccaa aatcccaggc agcatggacc tcagtcttct ctgggtactt     60

ctgcccctag tcaccatggc ctggggccag tatggcgatt atggataccc ataccagcag    120

tatcatgact acagcgatga tgggtgggtg aatttgaacc ggcaaggctt cagctaccag    180

tgtccccagg ggcaggtgat agtggccgtg aggagcatct tcagcaagaa ggaaggttct    240

gacagacaat ggaactacgc ctgcatgccc acgccacaga gcctcgggga acccacggag    300

tgctggtggg aggagatcaa cagggctggc atggaatggt accagacgtg ctccaacaat    360

gggctggtgg caggattcca gagccgctac ttcgagtcag tgctggatcg ggagtggcag    420

ttttactgtt gtcgctacag caagaggtgc ccatattcct gctggctaac aacagaatat    480

ccaggtcact atggtgagga aatggacatg atttcctaca attatgatta ctatatccga    540

ggagcaacaa ccactttctc tgcagtggaa agggatcgcc agtggaagtt cataatgtgc    600

cggatgactg aatacgactg tgaatttgca aatgtttaga tttgccacat accaaatctg    660

ggtgaaagga aaggggccgg ggacaggagg gtgtccacat atgttaacat cagttggatc    720

tcctatagaa gtttctgctg ctctctttcc ttctccctga gctggtaact gcaatgccaa    780

cttcctgggc ctttctgact agtatcacac ttctaataaa atccacaatt aaaccatgtt    840

tctcactttt cacatgtttc atagcaactg ctttatatga ctgatgatgg cttccttgca    900

caccacatat acagtgcgca tgcttacagc cgggcttctg gagcaccagc tgcagcctgg    960

ctactgcttt ttactgcaga atgaactgca agttcagcat agtggagggg agaggcagaa   1020

ctggaggaga ggtgcagtga aggttctcta cagctaagcc tgtttgaatg atacgtaggt   1080

tccccaccaa aagcaggctt tctgccctga gggacatctt cccactcccc tgctccacat   1140

gagccatgca tgcttagcaa tccaagtgca gagctctttg ctccaggagt gaggagactg   1200

ggaggtgaaa tggggaaatg gaagggtttg gaggcagagc tgaaaacagg gttggaagga   1260

tttcctgaat tagaagacaa acgttagcat acccagtaag gaaaatgagt gcaggggcca   1320

ggggaacccg tgaggatcac tctcaaatga gattaaaaac aaggaagcag agaatggtca   1380

gagaatggga ttcagattgg gaacttgtgg ggatgagagt gaccaggttg aactgggaag   1440

tggaaaaagg agtttgagtc actggcacct agaagcctgc ccacgattcc taggaaggct   1500

ggcagacacc ctggaaccct ggggagctac tggcaaactc tcctggattg ggcctgattt   1560

ttttggtggg aaaggctgcc ctggggatca actttccttc tgtgtgtggc tcaggagttc   1620

ttctgcagag atggcgctat ctttcctcct cctgtgatgt cctgctccca accatttgta   1680

ctcttcatta caaaagaaat aaaaatatta acgttcacta tgctgaaa                1728


<210>  1917
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  1917

Met Asp Leu Ser Leu Leu Trp Val Leu Leu Pro Leu Val Thr Met Ala 
1               5                   10                  15


Trp Gly Gln Tyr Gly Asp Tyr Gly Tyr Pro Tyr Gln Gln Tyr His Asp 
            20                  25                  30


Tyr Ser Asp Asp Gly Trp Val Asn Leu Asn Arg Gln Gly Phe Ser Tyr 
        35                  40                  45


Gln Cys Pro Gln Gly Gln Val Ile Val Ala Val Arg Ser Ile Phe Ser 
    50                  55                  60


Lys Lys Glu Gly Ser Asp Arg Gln Trp Asn Tyr Ala Cys Met Pro Thr 
65                  70                  75                  80


Pro Gln Ser Leu Gly Glu Pro Thr Glu Cys Trp Trp Glu Glu Ile Asn 
                85                  90                  95


Arg Ala Gly Met Glu Trp Tyr Gln Thr Cys Ser Asn Asn Gly Leu Val 
            100                 105                 110


Ala Gly Phe Gln Ser Arg Tyr Phe Glu Ser Val Leu Asp Arg Glu Trp 
        115                 120                 125


Gln Phe Tyr Cys Cys Arg Tyr Ser Lys Arg Cys Pro Tyr Ser Cys Trp 
    130                 135                 140


Leu Thr Thr Glu Tyr Pro Gly His Tyr Gly Glu Glu Met Asp Met Ile 
145                 150                 155                 160


Ser Tyr Asn Tyr Asp Tyr Tyr Ile Arg Gly Ala Thr Thr Thr Phe Ser 
                165                 170                 175


Ala Val Glu Arg Asp Arg Gln Trp Lys Phe Ile Met Cys Arg Met Thr 
            180                 185                 190


Glu Tyr Asp Cys Glu Phe Ala Asn Val 
        195                 200


<210>  1918
<211>  515
<212>  DNA
<213>  Homo sapiens

<400>  1918
cagcaggggt gagctgacca ccagtgatga acagaggcct ccacacagcc agtgacctaa     60

ttagtcacct tcaagggtga cctgaactca cagatttgtc ggttcttggg aaactgcata    120

aagatgtctt ctaagagcaa agtgagatta agtgtccctt cagttcccag atcctccaaa    180

tgttctctgc tgctgtttcc ccagcagcga ttcttcctgc catgtccttt ctcactgaca    240

ttcattttct gactctccct cccacaggga tcgccagtgg aagttcataa tgtgccggat    300

gactgaatac gactgtgaat ttgcaaatgt ttagatttgc cacataccaa atctgggtga    360

aaggaaaggg gccggggaca ggagggtgtc cacatatgtt aacatcagtt ggatctccta    420

tagaagtttc tgctgctctc tttccttctc ctgtgatgtc ctgctcccaa ccatttgtac    480

tcttcattac aaaagaaata aaaatattaa cgttc                               515


<210>  1919
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  1919

Met Phe Arg Phe Ala Thr Tyr Gln Ile Trp Val Lys Gly Lys Gly Pro 
1               5                   10                  15


Gly Thr Gly Gly Cys Pro His Met Leu Thr Ser Val Gly Ser Pro Ile 
            20                  25                  30


Glu Val Ser Ala Ala Leu Phe Pro Ser Pro Val Met Ser Cys Ser Gln 
        35                  40                  45


Pro Phe Val Leu Phe Ile Thr Lys Glu Ile Lys Ile Leu Thr 
    50                  55                  60


<210>  1920
<211>  850
<212>  DNA
<213>  Homo sapiens

<400>  1920
agagtgacat tgtttgccaa aatcccaggc agcatggacc tcagtcttct ctgggtactt     60

ctgcccctag tcaccatggc ctggggccag tatggcgatt atggataccc ataccagcag    120

tatcatgact acagcgatga tgggtgggtg aatttgaacc ggcaaggctt cagctaccag    180

tgtccccagg ggcaggtgat agtggccgtg aggagcatct tcagcaagaa ggaaggttct    240

gacagacaat ggaactacgc ctgcatgccc acgccacaga gcctcgggga acccacggag    300

tgctggtggg aggagatcaa cagggctggc atggaatggt accagacgtg ctccaacaat    360

gggctggtgg caggattcca gagccgctac ttcgagtcag tgctggatcg ggagtggcag    420

ttttactgtt gtcgctacag caagaggtgc ccatattcct gctggctaac aacagaatat    480

ccaggtcact atggtgagga aatggacatg atttcctaca attatgatta ctatatccga    540

ggagcaacaa ccactttctc tgcagtggaa agggatcgcc agtggaagtt cataatgtgc    600

cggatgactg aatacgactg tgaatttgca aatgtttaga tttgccacat accaaatctg    660

ggtgaaagga aaggggccgg ggacaggagg gtgtccacat atgttaacat cagttggatc    720

tcctatagaa gtttctgctg ctctctttcc ttctccctga gctggtaact gcaatgccaa    780

cttcctgggc ctttctgact agtatcacac ttctaataaa atccacaatt aaaccatgtt    840

tctcactttt                                                           850


<210>  1921
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  1921

Met Asp Leu Ser Leu Leu Trp Val Leu Leu Pro Leu Val Thr Met Ala 
1               5                   10                  15


Trp Gly Gln Tyr Gly Asp Tyr Gly Tyr Pro Tyr Gln Gln Tyr His Asp 
            20                  25                  30


Tyr Ser Asp Asp Gly Trp Val Asn Leu Asn Arg Gln Gly Phe Ser Tyr 
        35                  40                  45


Gln Cys Pro Gln Gly Gln Val Ile Val Ala Val Arg Ser Ile Phe Ser 
    50                  55                  60


Lys Lys Glu Gly Ser Asp Arg Gln Trp Asn Tyr Ala Cys Met Pro Thr 
65                  70                  75                  80


Pro Gln Ser Leu Gly Glu Pro Thr Glu Cys Trp Trp Glu Glu Ile Asn 
                85                  90                  95


Arg Ala Gly Met Glu Trp Tyr Gln Thr Cys Ser Asn Asn Gly Leu Val 
            100                 105                 110


Ala Gly Phe Gln Ser Arg Tyr Phe Glu Ser Val Leu Asp Arg Glu Trp 
        115                 120                 125


Gln Phe Tyr Cys Cys Arg Tyr Ser Lys Arg Cys Pro Tyr Ser Cys Trp 
    130                 135                 140


Leu Thr Thr Glu Tyr Pro Gly His Tyr Gly Glu Glu Met Asp Met Ile 
145                 150                 155                 160


Ser Tyr Asn Tyr Asp Tyr Tyr Ile Arg Gly Ala Thr Thr Thr Phe Ser 
                165                 170                 175


Ala Val Glu Arg Asp Arg Gln Trp Lys Phe Ile Met Cys Arg Met Thr 
            180                 185                 190


Glu Tyr Asp Cys Glu Phe Ala Asn Val 
        195                 200


<210>  1922
<211>  606
<212>  DNA
<213>  Homo sapiens

<400>  1922
tgaaggttag aaataataat gggcatctct gctgcatttc tgactttaaa agaatagatt     60

ctaaggctca caattaacag tgcatacctc ctgggaacat gttaccaaaa gttagaaggc    120

caaattccct cagcctctat ccagcatcac aaataacttc aatgagaacc ataggaacat    180

cgagtgtcct gtgaatctga gaactgcaat gggccctagg ggctcttcca tccaggctta    240

tcatgattca ggagaagaaa ttgaggaccg aagacatcaa atataataag ctaatggagg    300

aactgaggct acttgcctgg ctccagtgct ctttcctttg cctcaaaatc tttacaggtc    360

agccatctat catgtgtaga ataagcaaac tgaattaaca ttggaaatat taaaagaaca    420

gaggttgcgt ggatattggt tggaacagag aagaagtttt cacaaggaat taaagtaaca    480

ccagctgctc actgctctga cttaaaccat acagcaactc cagaaacatg gggggtgttg    540

ttgagtggca aggtaagctc aagaatgcta aatgtgtctg aaggcaaagg ggattatttg    600

tcattg                                                               606


<210>  1923
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  1923

Met Ile Gln Glu Lys Lys Leu Arg Thr Glu Asp Ile Lys Tyr Asn Lys 
1               5                   10                  15


Leu Met Glu Glu Leu Arg Leu Leu Ala Trp Leu Gln Cys Ser Phe Leu 
            20                  25                  30


Cys Leu Lys Ile Phe Thr Gly Gln Pro Ser Ile Met Cys Arg Ile Ser 
        35                  40                  45


Lys Leu Asn 
    50


<210>  1924
<211>  1129
<212>  DNA
<213>  Homo sapiens

<400>  1924
acatttcaca gatggcacag agtggggaag tcagtgaccc aaggtggcaa gccagctctt     60

gctgatggtg aggagcctca ttatcttaag acaacacaca gtggagatgt gctttacgta    120

attggcctgc cctgtgaaaa cccctggctg ttttttcaga taaggagact gaagcatcta    180

gagttggagt aatttccaca agatcacaga gctgaaacca caggaagagg ccaatatgga    240

cttctctact actttatttc ccctgagcct ggtcagcttc ttccaaggag attactggga    300

ggaagcttct aggatttctg gacattggat tccctgctgg tttccccacc tgattattga    360

aattgatttc tggagttcag gaaaaagcaa gtcatcatat atcaacctat tatgtgtgtt    420

aggctgtttg cattatcaca tttaatccat ttgacgctgt gaaggagcag gtagtgttat    480

ctgactcaag tctgtccttc aattaatctc accacctcca ggattccttt atgctctttg    540

tcaagaactc tggtagagca aagaaaatgg ggatagtttg tcacgttcaa aaatcgtatt    600

gaccaagact atcctctctc tctctctctt ttttttgaga cagagtctca ctctgtcacc    660

aggctggagt gcagtggtgt aatctcagct cactgcaacc tccgcctcct gggttcaagt    720

gattctcctg cctcagcctt ccgagtagct gggactacag gtgcatgcca ccatgcccag    780

ctaatttttg tatttttagt agaatcaggg tttcaccatg ttggccagga tggtctcgat    840

ctcctgacct cgtgatctgc ccgccttggc ctcccaaagt gctgggacta caggcatgag    900

ccactgtgcc tggctgataa tcctctttta agaagaaggg gtatatattt acctagggaa    960

ttccctagag gagaagaggc agaaaggcat aaaaggagta tagtaaactg aaatcaagac   1020

atctaaatct aagacctggc tccattactg tacccctttg gaactttggg taaattctta   1080

attctttctg ggtctcaatt ttctctttta ataaaacaaa gatttggag               1129


<210>  1925
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  1925

Met Asp Phe Ser Thr Thr Leu Phe Pro Leu Ser Leu Val Ser Phe Phe 
1               5                   10                  15


Gln Gly Asp Tyr Trp Glu Glu Ala Ser Arg Ile Ser Gly His Trp Ile 
            20                  25                  30


Pro Cys Trp Phe Pro His Leu Ile Ile Glu Ile Asp Phe Trp Ser Ser 
        35                  40                  45


Gly Lys Ser Lys Ser Ser Tyr Ile Asn Leu Leu Cys Val Leu Gly Cys 
    50                  55                  60


Leu His Tyr His Ile 
65


<210>  1926
<211>  780
<212>  DNA
<213>  Homo sapiens

<400>  1926
gcttggagaa gaggaggagg ctgaaaagaa ggcaaagagt gaagatagag aaacaagatg     60

gaagtggggg agaaaaacag ggatgagaga atgccatggt ggtgctgaga aggaaaggag    120

agacttttct gcttgtaaag ggcagaagat ggcagaatcc agtgacgcag gggcatctgg    180

ctccagaaat aataggtcac ttggcaccca cttcttcaaa acaactcgta gaggtaccac    240

cttggttgtc ttggataaaa tctggaataa ttatctgggt taccaggaga gacccttgtt    300

cttttcgctt actttctcca aaacatatga agcctctctc tctgtgctga accacctgga    360

actggaggtg tgatgagtta tagagatgaa aatgcatatg gaattatcat gcaaattacc    420

aataaagaga atcactggtc agaatcccta tattttggag aagaaaaatt ttgaaaacca    480

gtcagaattc aatcaactgc agttgggaga aagacagcga gtagcttgag agagatgaga    540

aactatcaaa aagaagttcc tgacatggca acagtgtatc atccaatgaa tcaatcgcct    600

cacccaacac tgtaacactt cctggcctat tgactcagag catgaggaaa ccaaagtgac    660

cagggattaa aagctatctc tggagaagat gatgtcagca agatggcaga atagaaaaat    720

ccaggtcctg gttccaccac agaaacatga agtaaacaac aaaggaatgg cttaatagcc    780


<210>  1927
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  1927

Met Arg Glu Cys His Gly Gly Ala Glu Lys Glu Arg Arg Asp Phe Ser 
1               5                   10                  15


Ala Cys Lys Gly Gln Lys Met Ala Glu Ser Ser Asp Ala Gly Ala Ser 
            20                  25                  30


Gly Ser Arg Asn Asn Arg Ser Leu Gly Thr His Phe Phe Lys Thr Thr 
        35                  40                  45


Arg Arg Gly Thr Thr Leu Val Val Leu Asp Lys Ile Trp Asn Asn Tyr 
    50                  55                  60


Leu Gly Tyr Gln Glu Arg Pro Leu Phe Phe Ser Leu Thr Phe Ser Lys 
65                  70                  75                  80


Thr Tyr Glu Ala Ser Leu Ser Val Leu Asn His Leu Glu Leu Glu Val 
                85                  90                  95


<210>  1928
<211>  520
<212>  DNA
<213>  Homo sapiens

<400>  1928
ctgatgtcaa ttcttattac agttctttaa gatttctgtt ttatcaaagg atctcacttt     60

cttcccacct cattctacaa tgtagtagta ttctaacact catgcacatc aaggtacttg    120

tgggagagaa tatcctccta aggaagacta tgttttcatt taacaacaaa taggccaggt    180

gcagtagctt ataccagtaa tccctttaga acgccaaggt aggaggatcg cttgaggcca    240

ggagtttgag accagcctaa catacaagga cctttgattc tgcaaaagat aaaaagcatt    300

agctgggcat ggtggtgctc acctatagtc ctagctatcc aggatgctga ggcaaaagga    360

tcatttgagc aaaggagttc aaggttacaa tgagctgtga tcgcatcact gcattccagt    420

atgggtgaca gttcttgctc acaagaacct gtctttataa aacaaatgaa caacttaaca    480

acaaatactt gttaacagat atttaattta ctatgtgcca                          520


<210>  1929
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  1929

Asp Gln Pro Asn Ile Gln Gly Pro Leu Ile Leu Gln Lys Ile Lys Ser 
1               5                   10                  15


Ile Ser Trp Ala Trp Trp Cys Ser Pro Ile Val Leu Ala Ile Gln Asp 
            20                  25                  30


Ala Glu Ala Lys Gly Ser Phe Glu Gln Arg Ser Ser Arg Leu Gln 
        35                  40                  45


<210>  1930
<211>  658
<212>  DNA
<213>  Homo sapiens

<400>  1930
cttagatctt aagccactgc tgatcttctt agaaccacac accgcaggtg cttccctgtg     60

gaaactgcaa atgtttactc tgtcttccac ctttgaatga cttagaacat gttgtggcta    120

aggttcattc gttatcaaca ttcagaaact gccatttcct tttctacctg caaagcctaa    180

taataacttt ttaaactatt gcttcctttg catattcacc atacatcctg ctttcagatg    240

tggaatctaa aaccttgctg agaaactgcc tccaatgttg ctcccttaac tttcactgtg    300

gaaaactctg aaggaagttg gccgcaccat ttaatggaag catgaggaac tagtctcttt    360

cctttagata tgtatgaaaa tggctccact gtgactcagc agatggctcc actgtgactc    420

agcagatctc caggattttc ctgtgtagtt tctgttttgg ctttcatctg gtgggaactg    480

actgctacag gaccgaggct tttaaatcaa acccaaataa caaaatgtat ttagagctga    540

aaaaggtggt gccatcaggc tggggtgggg atgaggaagt gattcattac cccagttgga    600

atgtaaattc aatgagttta attactagtg gtgtcaaaaa aggattttca ctgatagc      658


<210>  1931
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  1931

Met Tyr Leu Glu Leu Lys Lys Val Val Pro Ser Gly Trp Gly Gly Asp 
1               5                   10                  15


Glu Glu Val Ile His Tyr Pro Ser Trp Asn Val Asn Ser Met Ser Leu 
            20                  25                  30


Ile Thr Ser Gly Val Lys Lys Gly Phe Ser Leu 
        35                  40


<210>  1932
<211>  2008
<212>  DNA
<213>  Homo sapiens

<400>  1932
catgacattg catccttcac ccatcacttg tgaatttttg ttttccacag ctctcatttc     60

tccaaaaatg tgtttgagcc acttggaaaa tatgccttta agccattcaa gaactcaagg    120

agctcagaga tcatcctgga agctgtggct cttttgctca atagttatgt tgctatttct    180

ttgctccttc agttggctaa tctttatttt tctccaatta gagactgcta aggagccctg    240

tatggctaag tttggaccat taccctcaaa atggcaaatg gcatcttctg aacctccttg    300

cgtgaataag gtgtctgact ggaagctgga gatacttcag aatggcttat atttaattta    360

tggccaagtg gctcccaatg caaactacaa tgatgtagct ccttttgagg tgcggctgta    420

taaaaacaaa gacatgatac aaactctaac aaacaaatct aaaatccaaa atgtaggagg    480

gacttatgaa ttgcatgttg gggacaccat agacttgata ttcaactctg agcatcaggt    540

tctaaaaaat aatacatact ggggtatcat tttactagca aatccccaat tcatctccta    600

gagacttgat ttgatctcct cattcccttc agcacatgta gaggtgccag tgggtggatt    660

ggagggagaa gatattcaat ttctagagtt tgtctgtcta caaaaatcaa cacaaacaga    720

actcctctgc acgtgaattt tcatctatca tgcctatctg aaagagactc aggggaagag    780

ccaaagactt ttggttggat ctgcagagat acttcattaa tccatgataa aacaaatatg    840

gatgacagag gacatgtgct tttcaaagaa tctttatcta attcttgaat tcatgagtgg    900

aaaaatggag ttctattccc atggaagatt tacctggtat gcaaaaagga tctggggcag    960

tagcctggct ttgttctcat attcttgggc tgctgtaatt cattcttctc atactcccat   1020

cttctgagac cctcccaata aaaagtagac tgataggatg gccacagata tgcctaccat   1080

accctacttt agatatggtg gtgttagaag ataaagaaca atctgagaac tattggaata   1140

gaggtacaag tggcataaaa tggaatgtac gctatctgga aatttctctt ggttttatct   1200

tcctcaggat gcagggtgct ttaaaaagcc ttatcaaagg agtcattccg aaccctcacg   1260

tagagctttg tgagacctta ctgttggtgt gtgtgtctaa acattgctaa ttgtaaagaa   1320

agagtaacca ttagtaatca ttaggtttaa ccccagaatg gtattatcat tactggatta   1380

tgtcatgtaa tgatttagta tttttagcta gctttccaca gtttgcaaag tgctttcgta   1440

aaacagttag caattctatg aagttaattg ggcaggcatt tgggggaaaa ttttagtgat   1500

gagaatgtga tagcatagca tagccaactt tcctcaactc ataggacaag tgactacaag   1560

aggcaatggg tagtcccctg cattgcactg tctcagcttt agaattgtta tttctgctat   1620

cgtgttataa gactctaaaa cttagcgaat tcacttttca ggaagcatat tcccctttag   1680

cccaaggtga gcagagtgaa gctacaacag atctttcctt taccagcaca cttttttttt   1740

ttttcctgcc tgaatcaggg agatccagga tgctgttcag gccttatccc aaccaaattc   1800

ccctcttcac tttgcagggc ccatcttagt caaatgtgct aacttctaaa ataataaata   1860

gcactaattc aaaatttttg gactcttaaa ttagctactt gcaggttctt gttgaaaggt   1920

atataatatt acattgtaaa caaatttaaa atatttatgg atatttgtga aaagctgcat   1980

tatgttaaat aatattacat gtaaagct                                      2008


<210>  1933
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  1933

Met Thr Leu His Pro Ser Pro Ile Thr Cys Glu Phe Leu Phe Ser Thr 
1               5                   10                  15


Ala Leu Ile Ser Pro Lys Met Cys Leu Ser His Leu Glu Asn Met Pro 
            20                  25                  30


Leu Ser His Ser Arg Thr Gln Gly Ala Gln Arg Ser Ser Trp Lys Leu 
        35                  40                  45


Trp Leu Phe Cys Ser Ile Val Met Leu Leu Phe Leu Cys Ser Phe Ser 
    50                  55                  60


Trp Leu Ile Phe Ile Phe Leu Gln Leu Glu Thr Ala Lys Glu Pro Cys 
65                  70                  75                  80


Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser 
                85                  90                  95


Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu 
            100                 105                 110


Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn 
        115                 120                 125


Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp 
    130                 135                 140


Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly 
145                 150                 155                 160


Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser 
                165                 170                 175


Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu 
            180                 185                 190


Ala Asn Pro Gln Phe Ile Ser 
        195


<210>  1934
<211>  963
<212>  DNA
<213>  Homo sapiens

<400>  1934
atgcatcaat gttccaacac ggtgaaccat tacgacaagc ccccagatct ctgcacgcac     60

ccacagcctg aatcatctgc tctgagcagc cagactcaca gacacgactg cagcaaacat    120

gggcacaaag caaaaaagca cagaaaactg gatgttccat ccctgggaaa ggacgcacaa    180

ccactctcgc acaaggagac tcaagccgga tcaaaaagca agtcacccta tgcagcctgg    240

cttcctctgt gctctttcct cccctacttc gagccccaat tcccagtcct gtcccaggaa    300

aggacccacc ctactcgctc tgacccgcaa ctccatagac acccagtcca ccctacagca    360

gtcccgagtc gcctccaaag gcacatgcag tttccttcac ggaaacttcg ctgcaagctc    420

agccactggc ccgcgcgccc tccccaccag cgatccgcgc acaaaacttc ccgaagccgg    480

ggacctgctg agccgcccgc gcccggaggc atggaagggc ggccagaggc cccaaggctt    540

gcgaaaaccc agcggctcga gcctgctccc ttctcggagc ctggctccgc tccccggcgg    600

cgcgtgagtc cccctcactg cttggtgaga accctgcatc ctcgagcggg atgctgccct    660

gagcgctgcg gcaaggggcg caacactcac accctaagtg ccaaagagcg cgggggcgtt    720

tcccacgcca ggacaattcc cacagaagtt gcaaaggaac ggacagagcg tgcagaggag    780

gaacaggcag cgcgtgcaga ggagattccg agaaggttag ggccaactac ggatctccaa    840

ggtccatgca tccccccaac acgtagaagc gcgggggcca gacccgtggc gccgccgggg    900

agtgcagcgc agccccgcag gcagtgcatg cggggcgcaa gacagacaca tctctggcag    960

taa                                                                  963


<210>  1935
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  1935

Met His Gln Cys Ser Asn Thr Val Asn His Tyr Asp Lys Pro Pro Asp 
1               5                   10                  15


Leu Cys Thr His Pro Gln Pro Glu Ser Ser Ala Leu Ser Ser Gln Thr 
            20                  25                  30


His Arg His Asp Cys Ser Lys His Gly His Lys Ala Lys Lys His Arg 
        35                  40                  45


Lys Leu Asp Val Pro Ser Leu Gly Lys Asp Ala Gln Pro Leu Ser His 
    50                  55                  60


Lys Glu Thr Gln Ala Gly Ser Lys Ser Lys Ser Pro Tyr Ala Ala Trp 
65                  70                  75                  80


Leu Pro Leu Cys Ser Phe Leu Pro Tyr Phe Glu Pro Gln Phe Pro Val 
                85                  90                  95


Leu Ser Gln Glu Arg Thr His Pro Thr Arg Ser Asp Pro Gln Leu His 
            100                 105                 110


Arg His Pro Val His Pro Thr Ala Val Pro Ser Arg Leu Gln Arg His 
        115                 120                 125


Met Gln Phe Pro Ser Arg Lys Leu Arg Cys Lys Leu Ser His Trp Pro 
    130                 135                 140


Ala Arg Pro Pro His Gln Arg Ser Ala His Lys Thr Ser Arg Ser Arg 
145                 150                 155                 160


Gly Pro Ala Glu Pro Pro Ala Pro Gly Gly Met Glu Gly Arg Pro Glu 
                165                 170                 175


Ala Pro Arg Leu Ala Lys Thr Gln Arg Leu Glu Pro Ala Pro Phe Ser 
            180                 185                 190


Glu Pro Gly Ser Ala Pro Arg Arg Arg Val Ser Pro Pro His Cys Leu 
        195                 200                 205


Val Arg Thr Leu His Pro Arg Ala Gly Cys Cys Pro Glu Arg Cys Gly 
    210                 215                 220


Lys Gly Arg Asn Thr His Thr Leu Ser Ala Lys Glu Arg Gly Gly Val 
225                 230                 235                 240


Ser His Ala Arg Thr Ile Pro Thr Glu Val Ala Lys Glu Arg Thr Glu 
                245                 250                 255


Arg Ala Glu Glu Glu Gln Ala Ala Arg Ala Glu Glu Ile Pro Arg Arg 
            260                 265                 270


Leu Gly Pro Thr Thr Asp Leu Gln Gly Pro Cys Ile Pro Pro Thr Arg 
        275                 280                 285


Arg Ser Ala Gly Ala Arg Pro Val Ala Pro Pro Gly Ser Ala Ala Gln 
    290                 295                 300


Pro Arg Arg Gln Cys Met Arg Gly Ala Arg Gln Thr His Leu Trp Gln 
305                 310                 315                 320


<210>  1936
<211>  567
<212>  DNA
<213>  Homo sapiens

<400>  1936
agcctaaaat gagccatcat ggtagaaaat caggtccctc atccaatttt cagccctgag     60

tcagacctag aagctctgaa atttaaaaaa aaaaaaaaaa gcattttacc agttaggaag    120

aatcttgtaa tattttgcaa gtatttacga aagtacagca ctttttcaaa tagataattg    180

gttctacaaa tcttataatt ctgctagagg atgaagtctt tgccgatttt ttcaacacat    240

ttctttccct cccggttttt ggtcagacac cattttatac tgttgaaaat tcacagtgga    300

gcttgtggcc agaaatacct tgtaacttga ttgccaaata caaagggtta ttgacctggt    360

tggaaaaatg ccgattacct ttcttctgta aaacaaactt gtgtttccat tacattctct    420

gtcaggagtt catcagtttc attaagtccc cagaaggagc caagatgatg agatggaaaa    480

aggcagacca gtggctactc cagaaatgca ttggcggggt cagagggatg tggcgcttct    540

attcctacct cacaggcagt gcaggtg                                        567


<210>  1937
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  1937

Met Val Glu Asn Gln Val Pro His Pro Ile Phe Ser Pro Glu Ser Asp 
1               5                   10                  15


Leu Glu Ala Leu Lys Phe Lys Lys Lys Lys Lys Ser Ile Leu Pro Val 
            20                  25                  30


Arg Lys Asn Leu Val Ile Phe Cys Lys Tyr Leu Arg Lys Tyr Ser Thr 
        35                  40                  45


Phe Ser Asn Arg 
    50


<210>  1938
<211>  532
<212>  DNA
<213>  Homo sapiens

<400>  1938
aaaatgagcc atcatggtag aaaatcaggt ccctcatcca attttcagcc ctgagtcaga     60

cctagaagct ctgaaattta aaaaaaaaaa aaaaagcatt ttaccagtta ggaagaatct    120

tgtaatattt tgcaagtatt tacgagataa ttggttctac aaatcttata attctgctag    180

aggatgaagt ctttgccgat tttttcaaca catttctttc cctcccggtt tttggtcaga    240

caccatttta tactgttgaa aattcacagt ggagcttgtg gccagaaata ccttgtaact    300

tgattgccaa atacaaaggg ttattgacct ggttggaaaa atgccgatta cctttcttct    360

gtaaaacaaa cttgtgtttc cattacattc tctgtcagga gttcatcagt ttcattaagt    420

ccccagaagg agccaagatg atgagatgga aaaaggcaga ccagtggcta ctccagaaat    480

gcattggcgg ggtcagaggg atgtggcgct tctattccta cctcacaggc ag            532


<210>  1939
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  1939

Met Val Glu Asn Gln Val Pro His Pro Ile Phe Ser Pro Glu Ser Asp 
1               5                   10                  15


Leu Glu Ala Leu Lys Phe Lys Lys Lys Lys Lys Ser Ile Leu Pro Val 
            20                  25                  30


Arg Lys Asn Leu Val Ile Phe Cys Lys Tyr Leu Arg Asp Asn Trp Phe 
        35                  40                  45


Tyr Lys Ser Tyr Asn Ser Ala Arg Gly 
    50                  55


<210>  1940
<211>  589
<212>  DNA
<213>  Homo sapiens

<400>  1940
aattctgccc ctaacaaatt actgtgtcag gaagagcatg gcaacatgag cagtgctgag     60

ataattggtt ctacaaatct tataattctg ctagaggatg aagtctttgc cgattttttc    120

aacacatttc tttccctccc ggtttttggt cagacaccat tttatactgt tgaaaattca    180

cagtggagct tgtggccaga aataccttgt aacttgattg ccaaatacaa agggttattg    240

acctggttgg aaaaatgccg attacctttc ttctgtaaaa caaacttgtg tttccattac    300

attctctgtc aggagttcat cagtttcatt aagtccccag aaggagaagc cagagtgagc    360

ctcttaaaaa gtaattggtg gtggtgctgg agggactccc aggaagatga tgaaatagga    420

agcactagga atctgtttcc tcatctagac aacaattgta ctggcagaat ctgtatgatc    480

caagatgatg agatggaaaa aggcagacca gtggctactc cagaaatgca ttggcggggt    540

cagagggatg tggcgcttct attcctacct cacaggcagt gcaggtggg                589


<210>  1941
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  1941

Met Ser Ser Ala Glu Ile Ile Gly Ser Thr Asn Leu Ile Ile Leu Leu 
1               5                   10                  15


Glu Asp Glu Val Phe Ala Asp Phe Phe Asn Thr Phe Leu Ser Leu Pro 
            20                  25                  30


Val Phe Gly Gln Thr Pro Phe Tyr Thr Val Glu Asn Ser Gln Trp Ser 
        35                  40                  45


Leu Trp Pro Glu Ile Pro Cys Asn Leu Ile Ala Lys Tyr Lys Gly Leu 
    50                  55                  60


Leu Thr Trp Leu Glu Lys Cys Arg Leu Pro Phe Phe Cys Lys Thr Asn 
65                  70                  75                  80


Leu Cys Phe His Tyr Ile Leu Cys Gln Glu Phe Ile Ser Phe Ile Lys 
                85                  90                  95


Ser Pro Glu Gly Glu Ala Arg Val Ser Leu Leu Lys Ser Asn Trp Trp 
            100                 105                 110


Trp Cys Trp Arg Asp Ser Gln Glu Asp Asp Glu Ile Gly Ser Thr Arg 
        115                 120                 125


Asn Leu Phe Pro His Leu Asp Asn Asn Cys Thr Gly Arg Ile Cys Met 
    130                 135                 140


Ile Gln Asp Asp Glu Met Glu Lys Gly Arg Pro Val Ala Thr Pro Glu 
145                 150                 155                 160


Met His Trp Arg Gly Gln Arg Asp Val Ala Leu Leu Phe Leu Pro His 
                165                 170                 175


Arg Gln Cys Arg 
            180


<210>  1942
<211>  554
<212>  DNA
<213>  Homo sapiens

<400>  1942
aaattactgt gtcaggaaga gcatggcaac atgagcagtg ctgagataat tggttctaca     60

aatcttataa ttctgctaga ggatgaagtc tttgccgatt ttttcaacac atttctttcc    120

ctcccggttt ttggtcagac accattttat actgttgaaa attcacagtg gagcttgtgg    180

ccagaaatac cttgtaactt gattgccaaa tacaaagggt tattgacctg gttggaaaaa    240

tgccgattac ctttcttctg taaaacaaac ttgtgtttcc attacattct ctgtcaggag    300

ttcatcagtt tcattaagtc cccagaagga gccaagatga tgagatggaa aaaggcagac    360

cagtggctac tccagaaatg cattggcggg gtcagaggga tgtggcgctt ctattcctac    420

ctcacaggca gtgcaggtga agaattggtg gatttctgga tccttgctga gaacatcctg    480

agcatagatg agatggacct ggaagtgaga gactactacc tgtccctcct cctcatgctg    540

agggccactc atct                                                      554


<210>  1943
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  1943

Met Ser Ser Ala Glu Ile Ile Gly Ser Thr Asn Leu Ile Ile Leu Leu 
1               5                   10                  15


Glu Asp Glu Val Phe Ala Asp Phe Phe Asn Thr Phe Leu Ser Leu Pro 
            20                  25                  30


Val Phe Gly Gln Thr Pro Phe Tyr Thr Val Glu Asn Ser Gln Trp Ser 
        35                  40                  45


Leu Trp Pro Glu Ile Pro Cys Asn Leu Ile Ala Lys Tyr Lys Gly Leu 
    50                  55                  60


Leu Thr Trp Leu Glu Lys Cys Arg Leu Pro Phe Phe Cys Lys Thr Asn 
65                  70                  75                  80


Leu Cys Phe His Tyr Ile Leu Cys Gln Glu Phe Ile Ser Phe Ile Lys 
                85                  90                  95


Ser Pro Glu Gly Ala Lys Met Met Arg Trp Lys Lys Ala Asp Gln Trp 
            100                 105                 110


Leu Leu Gln Lys Cys Ile Gly Gly Val Arg Gly Met Trp Arg Phe Tyr 
        115                 120                 125


Ser Tyr Leu Thr Gly Ser Ala Gly Glu Glu Leu Val Asp Phe Trp Ile 
    130                 135                 140


Leu Ala Glu Asn Ile Leu Ser Ile Asp Glu Met Asp Leu Glu Val Arg 
145                 150                 155                 160


Asp Tyr Tyr Leu Ser Leu Leu Leu Met Leu Arg Ala Thr 
                165                 170


<210>  1944
<211>  726
<212>  DNA
<213>  Homo sapiens

<400>  1944
aggaagagca tggcaacatg agcagtgctg agataattgg ttctacaaat cttataattc     60

tgctagagga tgaagtcttt gccgattttt tcaacacatt tctttccctc ccggtttttg    120

gtcagacacc attttatact gttgaaaatt cacagtggag cttgtggcca gaaatacctt    180

gtaacttgat tgccaaatac aaagggttat tgacctggtt ggaaaaatgc cgattacctt    240

tcttctgtaa aacaaacttg tgtttccatt acattctctg tcaggagttc atcagtttca    300

ttaagtcccc agaaggagaa gccagagtga gcctcttaaa aagtaattgg tggtggtgct    360

ggagggactc ccaggaagat gatgaaatag gaagcactag gaatctgttt cctcatctag    420

acaacaattg tactggcaga atctgtatga tatgctcagt ccctggtatg atgagtttct    480

agatgaagag gactactggt ttctcctttt tacgagtcaa ccaaagatca gcatggtccc    540

tgttgttcta aagctaaacc tctcaaggaa aaggactcag tgcataagat gactttgaca    600

cagaacaggt tcatcagctc cagacagcat aaaagagaat ttataggcaa agaagagaac    660

attcttcttt ataagaggat tcagcagtct ctagagttaa gccaggcttt ggctgacatg    720

aaggaa                                                               726


<210>  1945
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  1945

Met Ser Ser Ala Glu Ile Ile Gly Ser Thr Asn Leu Ile Ile Leu Leu 
1               5                   10                  15


Glu Asp Glu Val Phe Ala Asp Phe Phe Asn Thr Phe Leu Ser Leu Pro 
            20                  25                  30


Val Phe Gly Gln Thr Pro Phe Tyr Thr Val Glu Asn Ser Gln Trp Ser 
        35                  40                  45


Leu Trp Pro Glu Ile Pro Cys Asn Leu Ile Ala Lys Tyr Lys Gly Leu 
    50                  55                  60


Leu Thr Trp Leu Glu Lys Cys Arg Leu Pro Phe Phe Cys Lys Thr Asn 
65                  70                  75                  80


Leu Cys Phe His Tyr Ile Leu Cys Gln Glu Phe Ile Ser Phe Ile Lys 
                85                  90                  95


Ser Pro Glu Gly Glu Ala Arg Val Ser Leu Leu Lys Ser Asn Trp Trp 
            100                 105                 110


Trp Cys Trp Arg Asp Ser Gln Glu Asp Asp Glu Ile Gly Ser Thr Arg 
        115                 120                 125


Asn Leu Phe Pro His Leu Asp Asn Asn Cys Thr Gly Arg Ile Cys Met 
    130                 135                 140


Ile Cys Ser Val Pro Gly Met Met Ser Phe 
145                 150


<210>  1946
<211>  555
<212>  DNA
<213>  Homo sapiens

<400>  1946
acactaacat cagatgcaac ctaggcaagg gttctcttat gttctgctct gggaagcatt     60

tgaagtattt cagttgtgag taccactcca gccaatgaga gaaccagatg gagagaaggc    120

catgtgagga atgggttgaa gaattgcctg gtgactagcc agtggggttg gagagataat    180

tggttctaca aatcttataa ttctgctaga ggatgaagtc tttgccgatt ttttcaacac    240

atttctttcc ctcccggttt ttggtcagac accattttat actgttgaaa attcacagtg    300

gagcttgtgg ccagaaatac cttgtaactt gattgccaaa tacaaagggt tattgacctg    360

gttggaaaaa tgccgattac ctttcttctg taaaacaaac ttgtgtttcc attacattct    420

ctgtcaggag ttcatcagtt tcattaagtc cccagaagga gccaagatga tgagatggaa    480

aaaggcagac cagtggctac tccagaaatg cattggcggg gtcagaggga tgtggcgctt    540

ctattcctac ctcac                                                     555


<210>  1947
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  1947

Met Lys Ser Leu Pro Ile Phe Ser Thr His Phe Phe Pro Ser Arg Phe 
1               5                   10                  15


Leu Val Arg His His Phe Ile Leu Leu Lys Ile His Ser Gly Ala Cys 
            20                  25                  30


Gly Gln Lys Tyr Leu Val Thr 
        35


<210>  1948
<211>  566
<212>  DNA
<213>  Homo sapiens

<400>  1948
aatgggggtc tggcagtgtg caaggctggg agaggggtca ggggaagagt tcattctccc     60

tctcttatgg tggaattttc ctggcagcca agatgatgag atggaaaaag gcagaccagt    120

ggctactcca gaaatgcatt ggcggggtca gagggatgtg gcgcttctat tcctacctca    180

caggcagtgc aggtgaagaa ttggtggatt tctggatcct tgctgagaac atcctgagca    240

tagatgagat ggacctggaa gtgagagact actacctgtc cctcctcctc atgctgaggg    300

ccactcatct gcaggagggc tccagggtgg taaccctctg taacatgaac atcagaaacc    360

ccaccttctt tccatcttct atgtatcaga gaggctagtg gcaaccccaa cccttaacca    420

ggaaatccct cctgaacctc tccatctggc atcccaacca atcaaccact aggagggaga    480

tcctgagcca catgcagaaa gtggctctgt tcaaactcca gagctattgg cttcccaact    540

tttacaccca caccaagatg accatg                                         566


<210>  1949
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  1949

Met Met Arg Trp Lys Lys Ala Asp Gln Trp Leu Leu Gln Lys Cys Ile 
1               5                   10                  15


Gly Gly Val Arg Gly Met Trp Arg Phe Tyr Ser Tyr Leu Thr Gly Ser 
            20                  25                  30


Ala Gly Glu Glu Leu Val Asp Phe Trp Ile Leu Ala Glu Asn Ile Leu 
        35                  40                  45


Ser Ile Asp Glu Met Asp Leu Glu Val Arg Asp Tyr Tyr Leu Ser Leu 
    50                  55                  60


Leu Leu Met Leu Arg Ala Thr His Leu Gln Glu Gly Ser Arg Val Val 
65                  70                  75                  80


Thr Leu Cys Asn Met Asn Ile Arg Asn Pro Thr Phe Phe Pro Ser Ser 
                85                  90                  95


Met Tyr Gln Arg Gly 
            100


<210>  1950
<211>  2063
<212>  DNA
<213>  Homo sapiens

<400>  1950
agatgctcag tccctggtat gatgagtttc tagatgaaga ggactactgg tttctccttt     60

ttacgacata actaaaatgt cctttgagga gctttgctac aagaacccaa agatggccat    120

acagaagatc agtgatgact acaaaatata ctgtgagaaa gcacctaaaa tagattttaa    180

aatggaaatt atcaaggaaa caaagacagt ttcacgctca aataggaaaa tgtccttgct    240

caaaagaact cttgtaagga agccatcaat gagacccaga aacttgacag aagtcctctt    300

aaatacacag cacttggagt tcttcaggga gttcctcaag gaacggaagg ctaaaatccc    360

attgcaattt ctcacagctg tacagaagat cagtatagag accaatgaaa agatttgcaa    420

gtctctcata gaaaatgtaa tcaagacttt cttccaaggc caactctctc ctgaagaaat    480

gctgcagtgt gatgccccta ttatcaaaga aatcgcttcc atgcgtcatg tcaccacaag    540

cacactgtta acgctccagg gacatgttat gaaatctata gaagaaaagt ggtttaaaga    600

ttatcaagac ctgttcccac ctcaccatca ggaggtggaa gtgcaaagtg aagtacaaat    660

ttcgtctagg aagccctcaa agatagtgtc aacttaccta caggaatccc agaagaaagg    720

ctggatgaga atgatcagct ttatcaggag tttttgcaag taccgcagat ttatgttgaa    780

tcctagtaag cgccaggaat ttgaagacta tcttcaccag gaaatgcaaa atagcaagga    840

aaatttcacc acagcacaca acacatcggg acgttcagct ccaccctcca caaatgtccg    900

gagtgcagac caagagaatg gagaaataac ccttgtaaag cgtcgtatat ttggccacag    960

gattatcact gtcaactttg cgatcaatga tctatatttc ttttctgaaa tggagaaatt   1020

taatgatctg gtcagttcag cccacatgct gcaggtcaac cgggcatata atgagaatga   1080

tgtgatccta atgcggtcca aaatgaacat tatccaaaaa ctcttcctga attctgacat   1140

ccctccaaag ctgagggtga atgtccctga gttccagaag gatgccatcc ttgctgccat   1200

cacagagggc tacctagatc ggagcgtctt ccatggggct atcatgtctg tcttccccgt   1260

tgttatgtac ttctggaaaa ggttttgttt ctggaaggca acccgctctt acttacagta   1320

tagggggaag aagttcaagg acagaaaaag ccctcctaaa tctacggaca agtatccttt   1380

ctcgagtgga ggagacaatg ccatcttaag gttcaccttg ctcagaggta ttgagtggtt   1440

gcagcctcaa cgggaagcaa taagttcagt tcaaaattct tcatcaagca aacttactca   1500

gccaagactc gtggtatctg ccatgcagct gcatcccgtc cagggacaaa aattatccta   1560

catcaaaaaa gagaagtaat caagcgagac ccccagcaga gataaatcat ctcttagagg   1620

cctcctaaca ctgacagaaa cttttctggt caaaaatgaa aggtcctggt accatcttcc   1680

ccagaaacga tcaagaaggg caatgggttg acagcccaga tatggcagga ccagactgca   1740

atgggaatct catacagccc attcagacta aagggtgatg gaaagaagca gaggaaagca   1800

gaaacagcaa gagtgactga gacctgctgt catctatata gaagcctttc tgatacatgt   1860

cagagagtga catgaagtct cccctcttta tacacacgta tgaaaataca tctatccctc   1920

attttgagag cctccaactg atccaagtgt catccggagg aggaggtggc ccgtatgtgc   1980

aggacctcag ggtgccagcc ctcacccata cacctccagg gctgcaggtc attagccaga   2040

ataaaggatg tccacattca caa                                           2063


<210>  1951
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  1951

Met Ser Phe Glu Glu Leu Cys Tyr Lys Asn Pro Lys Met Ala Ile Gln 
1               5                   10                  15


Lys Ile Ser Asp Asp Tyr Lys Ile Tyr Cys Glu Lys Ala Pro Lys Ile 
            20                  25                  30


Asp Phe Lys Met Glu Ile Ile Lys Glu Thr Lys Thr Val Ser Arg Ser 
        35                  40                  45


Asn Arg Lys Met Ser Leu Leu Lys Arg Thr Leu Val Arg Lys Pro Ser 
    50                  55                  60


Met Arg Pro Arg Asn Leu Thr Glu Val Leu Leu Asn Thr Gln His Leu 
65                  70                  75                  80


Glu Phe Phe Arg Glu Phe Leu Lys Glu Arg Lys Ala Lys Ile Pro Leu 
                85                  90                  95


Gln Phe Leu Thr Ala Val Gln Lys Ile Ser Ile Glu Thr Asn Glu Lys 
            100                 105                 110


Ile Cys Lys Ser Leu Ile Glu Asn Val Ile Lys Thr Phe Phe Gln Gly 
        115                 120                 125


Gln Leu Ser Pro Glu Glu Met Leu Gln Cys Asp Ala Pro Ile Ile Lys 
    130                 135                 140


Glu Ile Ala Ser Met Arg His Val Thr Thr Ser Thr Leu Leu Thr Leu 
145                 150                 155                 160


Gln Gly His Val Met Lys Ser Ile Glu Glu Lys Trp Phe Lys Asp Tyr 
                165                 170                 175


Gln Asp Leu Phe Pro Pro His His Gln Glu Val Glu Val Gln Ser Glu 
            180                 185                 190


Val Gln Ile Ser Ser Arg Lys Pro Ser Lys Ile Val Ser Thr Tyr Leu 
        195                 200                 205


Gln Glu Ser Gln Lys Lys Gly Trp Met Arg Met Ile Ser Phe Ile Arg 
    210                 215                 220


Ser Phe Cys Lys Tyr Arg Arg Phe Met Leu Asn Pro Ser Lys Arg Gln 
225                 230                 235                 240


Glu Phe Glu Asp Tyr Leu His Gln Glu Met Gln Asn Ser Lys Glu Asn 
                245                 250                 255


Phe Thr Thr Ala His Asn Thr Ser Gly Arg Ser Ala Pro Pro Ser Thr 
            260                 265                 270


Asn Val Arg Ser Ala Asp Gln Glu Asn Gly Glu Ile Thr Leu Val Lys 
        275                 280                 285


Arg Arg Ile Phe Gly His Arg Ile Ile Thr Val Asn Phe Ala Ile Asn 
    290                 295                 300


Asp Leu Tyr Phe Phe Ser Glu Met Glu Lys Phe Asn Asp Leu Val Ser 
305                 310                 315                 320


Ser Ala His Met Leu Gln Val Asn Arg Ala Tyr Asn Glu Asn Asp Val 
                325                 330                 335


Ile Leu Met Arg Ser Lys Met Asn Ile Ile Gln Lys Leu Phe Leu Asn 
            340                 345                 350


Ser Asp Ile Pro Pro Lys Leu Arg Val Asn Val Pro Glu Phe Gln Lys 
        355                 360                 365


Asp Ala Ile Leu Ala Ala Ile Thr Glu Gly Tyr Leu Asp Arg Ser Val 
    370                 375                 380


Phe His Gly Ala Ile Met Ser Val Phe Pro Val Val Met Tyr Phe Trp 
385                 390                 395                 400


Lys Arg Phe Cys Phe Trp Lys Ala Thr Arg Ser Tyr Leu Gln Tyr Arg 
                405                 410                 415


Gly Lys Lys Phe Lys Asp Arg Lys Ser Pro Pro Lys Ser Thr Asp Lys 
            420                 425                 430


Tyr Pro Phe Ser Ser Gly Gly Asp Asn Ala Ile Leu Arg Phe Thr Leu 
        435                 440                 445


Leu Arg Gly Ile Glu Trp Leu Gln Pro Gln Arg Glu Ala Ile Ser Ser 
    450                 455                 460


Val Gln Asn Ser Ser Ser Ser Lys Leu Thr Gln Pro Arg Leu Val Val 
465                 470                 475                 480


Ser Ala Met Gln Leu His Pro Val Gln Gly Gln Lys Leu Ser Tyr Ile 
                485                 490                 495


Lys Lys Glu Lys 
            500


<210>  1952
<211>  5095
<212>  DNA
<213>  Homo sapiens

<400>  1952
gtatatgaat ctttgaaccc agactttgga caactaaact ctatctctgt ttttccttac     60

ttcacagaca taactaaaat gtcctttgag gagctttgct acaagaaccc aaagatggcc    120

atacagaaga tcagtgatga ctacaaaata tactgtgaga aagcacctaa aatagatttt    180

aaaatggaaa ttatcaagga aacaaagaca gtttcacgct caaataggaa aatgtccttg    240

ctcaaaagaa ctcttgtaag gaagccatca atgagaccca gaaacttgac agaagtcctc    300

ttaaatacac agcacttgga gttcttcagg gagttcctca aggaacggaa ggctaaaatc    360

ccattgcaat ttctcacagc tgtacagaag atcagtatag agaccaatga aaagatttgc    420

aagtctctca tagaaaatgt aatcaagact ttcttccaag gccaactctc tcctgaagaa    480

atgctgcagt gtgatgcccc tattatcaaa gaaatcgctt ccatgcgtca tgtcaccaca    540

agcacactgt taacgctcca gggacatgtt atgaaatcta tagaagaaaa gtggtttaaa    600

gattatcaag acctgttccc acctcaccat caggaggtgg aagtgcaaag tgaagtacaa    660

atttcgtcta ggaagccctc aaagatagtg tcaacttacc tacaggaatc ccagaagaaa    720

ggctggatga gaatgatcag ctttatcagg agtttttgca agtaccgcag atttatgttg    780

aatcctagta agcgccagga atttgaagac tatcttcacc aggaaatgca aaatagcaag    840

gaaaatttca ccacagcaca caacacatcg ggacgttcag ctccaccctc cacaaatgtc    900

cggagtgcag accaagagaa tggagaaata acccttgtaa agcgtcgtat atttggccac    960

aggattatca ctgtcaactt tgcgatcaat gatctatatt tcttttctga aatggagaaa   1020

tttaatgatc tggtcagttc agcccacatg ctgcaggtca accgggcata taatgagaat   1080

gatgtgatcc taatgcggtc caaaatgaac attatccaaa aactcttcct gaattctgac   1140

atccctccaa agctgagggt gaatgtccct gagttccaga aggatgccat ccttgctgcc   1200

atcacagagg gctacctaga tcggagcgtc ttccatgggg ctatcatgtc tgtcttcccc   1260

gttgttatgt acttctggaa aaggtaactg tttctcctta ttcagtgact gttaggtcag   1320

gaaaacacac ttagtttgga gagagttttc tgccttcctc tagcactctg tttcgtagtt   1380

tccagtttct agggggaact aagatggtgt tttcaaaatc ctattcacct cactccatcc   1440

ctcacacaga acaccaaaca ctgaatccac agatggaagg cagagtaaga ctgagagcca   1500

aacgcctggt ttcccacccc tcctctttct atgcttgctt ggagcaagaa tgtgaggttt   1560

tcttaggcct gggtttctca caagaaggta agagtgaacc acagcccctt ggggagaaat   1620

tctgtcaaga ctaacacaac tgcttgtgct taagaagcta catgaagaaa gtaagccaga   1680

agtgttttgc tctgttatgc ccaaatcccc agaattacca ctgagggagc acagttgcta   1740

gatactccaa ttatcaagag gagctagaca ttgaaatgtg tatttcatct ctcccaaggt   1800

taaagtggca aatatggcaa ctaacaaaac taaaacatgg tgaagaaact gtgaaggcca   1860

aaaaccaaaa atgaaacaag caaaatatat gcagatattt tgtggccaaa tgcaatctgt   1920

ggcccacttg tttctaacct gtcctgtgga gatttggcct gagccttccc agctggttat   1980

ttattcctgt ggtctgccag agttccagct catatcttcc acatggtgaa tggcagtgcc   2040

ttgggtggta gtgaccagag gacacctggc tgaaatgttc ccagacaaag ctaatcagga   2100

cacttagatt atcatgtgac ttggactctt agaagttccc atcttccacc aaaaaaaaaa   2160

gttactttat taaaatagaa gtgtgaaatt gcttaccaat ctctcacctt tattttaaaa   2220

tccttgagat aataaactat ttaatacaga accaagagaa gtacaaaaat ctaagttcaa   2280

gacaagcaat ttaacctttt gaacatcaaa tgttgtctag aacttaactc tagttctcct   2340

agcaaggact aagtagatat tcacccagag acttttggag ggattgggaa cctctgggaa   2400

atatatgctt ctcttgaatg agccagtgtt tagctgtctc ccatgtgctt agaaaaatga   2460

gacatgcttt agggattctt tggattcctg ttcctcctgc agtttcttta cttactttcc   2520

tacatactta caaagaaatt tatgtcttgg tctctcatca ccataaataa tgcatgtgcg   2580

gcatactggg aggtccactg gggaaggaga cccagttcag caagtgaaat gggaaaagcc   2640

tattgagata gaacagactg tccctcaagg agaggggagg agggcagcag gcaaaaccac   2700

cagatccaaa gtgccataga aaataaattc agtcttagcc aagattgacc tccaagggat   2760

ccaatccaag gactggttga aggtagggat aacaaggggc ttggggccag gaaggaagag   2820

atgatgggga atattgcaca ggcttctaga gaacataaag gtcataaaga gtacataaat   2880

ctgagttcac aagagaaacc aggtctattc cagggaaggg cccgctggga atagagtgag   2940

gtggtcaagg ctgtcagtaa gtggcagggt ggaaactagg attaggacct gagcaaaagc   3000

ccttcagaca ctctggccat accaggtggg gttagatagg gatgtcagag tctgatgctg   3060

gggtgcaccc caggggttaa cctcacccca ggcctcagga tagtaggccc tttacaggct   3120

ccattcactg atggttccag aaagaagccc caacaaactg cccatgccag gcccgcgctg   3180

gagccaggtc tggacaaaga ggaggcctca gaacaaaggc cactggcagg tagaacccca   3240

aggccaggat gctttcctct tctctgttgg acacccacat tctctgagga ctggcccggc   3300

cctgtttccc ctgtgctcgg tgctccagcc ccctccactg ggggttccct cctatgacca   3360

gaagccattc ttcccacagg ttttgtttct ggaaggcaac ccgctcttac ttacagtata   3420

gggggaagaa gttcaaggac agaaaaagcc ctcctaaatc tacggacaag tatcctttct   3480

cgagtggagg agacaatgcc atcttaaggt tcaccttgct cagaggtatt gagtggttgc   3540

agcctcaacg ggaagcaata agttcagttc aaaattcttc atcaagcaaa cttactcagc   3600

caagactcgt ggtatctgcc atgcagctgc atcccgtcca ggggtaggca tgagctggaa   3660

atcctcttct tcagtccaga gctgctatgt ccaagcatgc aataggagat ggtataaact   3720

ttccagagac tagcctcata ccctgcctct ccttggcatg cagaacctag aaactgagct   3780

tgctgcctct ggtgggaagt taaagaggtg tttctctgtg ggggtccttt ctcacctcca   3840

actaggacag gcacttttaa gaagttggag tctctgaccc acttttcagt agaacaatac   3900

tgctgtggaa gtgtcccaga tgatctttga tttttaatga tcttttattg ccagcttcct   3960

aaatattcca ggctgctcag ggcagggtgc ataaggtggg aaagaaagaa gatctgttct   4020

tctgcttggc aggatattgg caataagaac agaagggact tgagtctgtt aaaatctgct   4080

tcagcctaac tcacttctgc acaagcttcc aagtgaaact gatgctaagt tagggctctg   4140

ggagaatccc caggggtcat gaaaaccata gctgaggagt gccaaagagt tatttgaagg   4200

ccaaggtggt agacagcagc ctctgaatga caggcttggt gtccttgcca gccaagtcac   4260

ttctcaggcc tgtttccaga cttgtccttc caacagggac ttgaagctgc ccaggaatta   4320

tttgcccgtc ccagtgccca gaagacaaac cagatacttt gaagctcttt acactggaaa   4380

agcaatgcat ggcttcagag tttataaggc cttggggaag aaggtgagac taagaatgtg   4440

agaagcccta ttctgaagcc tgaaggtttc agttttggct attgccattc ctaaaggaaa   4500

tgacagtgac aaaccaacag agaatgcaac ctcaattact gcatcataat tgtgataact   4560

ggctgttttc tctcccttca gacaaaaatt atcctacatc aaaaaagaga agtaatcaag   4620

cgagaccccc agcagagata aatcatctct tagaggcctc ctaacactga cagaaacttt   4680

tctggtcaaa aatgaaaggt cctggtacca tcttccccag aaacgatcaa gaagggcaat   4740

gggttgacag cccagatatg gcaggaccag actgcaatgg gaatctcata cagcccattc   4800

agactaaagg gtgatggaaa gaagcagagg aaagcagaaa cagcaagagt gactgagacc   4860

tgctgtcatc tatatagaag cctttctgat acatgtcaga gagtgacatg aagtctcccc   4920

tctttataca cacgtatgaa aatacatcta tccctcattt tgagagcctc caactgatcc   4980

aagtgtcatc cggaggagga ggtggcccgt atgtgcagga cctcagggtg ccagccctca   5040

cccatacacc tccagggctg caggtcatta gccagaataa aggatgtcca cattc        5095


<210>  1953
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  1953

Met Ser Phe Glu Glu Leu Cys Tyr Lys Asn Pro Lys Met Ala Ile Gln 
1               5                   10                  15


Lys Ile Ser Asp Asp Tyr Lys Ile Tyr Cys Glu Lys Ala Pro Lys Ile 
            20                  25                  30


Asp Phe Lys Met Glu Ile Ile Lys Glu Thr Lys Thr Val Ser Arg Ser 
        35                  40                  45


Asn Arg Lys Met Ser Leu Leu Lys Arg Thr Leu Val Arg Lys Pro Ser 
    50                  55                  60


Met Arg Pro Arg Asn Leu Thr Glu Val Leu Leu Asn Thr Gln His Leu 
65                  70                  75                  80


Glu Phe Phe Arg Glu Phe Leu Lys Glu Arg Lys Ala Lys Ile Pro Leu 
                85                  90                  95


Gln Phe Leu Thr Ala Val Gln Lys Ile Ser Ile Glu Thr Asn Glu Lys 
            100                 105                 110


Ile Cys Lys Ser Leu Ile Glu Asn Val Ile Lys Thr Phe Phe Gln Gly 
        115                 120                 125


Gln Leu Ser Pro Glu Glu Met Leu Gln Cys Asp Ala Pro Ile Ile Lys 
    130                 135                 140


Glu Ile Ala Ser Met Arg His Val Thr Thr Ser Thr Leu Leu Thr Leu 
145                 150                 155                 160


Gln Gly His Val Met Lys Ser Ile Glu Glu Lys Trp Phe Lys Asp Tyr 
                165                 170                 175


Gln Asp Leu Phe Pro Pro His His Gln Glu Val Glu Val Gln Ser Glu 
            180                 185                 190


Val Gln Ile Ser Ser Arg Lys Pro Ser Lys Ile Val Ser Thr Tyr Leu 
        195                 200                 205


Gln Glu Ser Gln Lys Lys Gly Trp Met Arg Met Ile Ser Phe Ile Arg 
    210                 215                 220


Ser Phe Cys Lys Tyr Arg Arg Phe Met Leu Asn Pro Ser Lys Arg Gln 
225                 230                 235                 240


Glu Phe Glu Asp Tyr Leu His Gln Glu Met Gln Asn Ser Lys Glu Asn 
                245                 250                 255


Phe Thr Thr Ala His Asn Thr Ser Gly Arg Ser Ala Pro Pro Ser Thr 
            260                 265                 270


Asn Val Arg Ser Ala Asp Gln Glu Asn Gly Glu Ile Thr Leu Val Lys 
        275                 280                 285


Arg Arg Ile Phe Gly His Arg Ile Ile Thr Val Asn Phe Ala Ile Asn 
    290                 295                 300


Asp Leu Tyr Phe Phe Ser Glu Met Glu Lys Phe Asn Asp Leu Val Ser 
305                 310                 315                 320


Ser Ala His Met Leu Gln Val Asn Arg Ala Tyr Asn Glu Asn Asp Val 
                325                 330                 335


Ile Leu Met Arg Ser Lys Met Asn Ile Ile Gln Lys Leu Phe Leu Asn 
            340                 345                 350


Ser Asp Ile Pro Pro Lys Leu Arg Val Asn Val Pro Glu Phe Gln Lys 
        355                 360                 365


Asp Ala Ile Leu Ala Ala Ile Thr Glu Gly Tyr Leu Asp Arg Ser Val 
    370                 375                 380


Phe His Gly Ala Ile Met Ser Val Phe Pro Val Val Met Tyr Phe Trp 
385                 390                 395                 400


Lys Arg 



<210>  1954
<211>  614
<212>  DNA
<213>  Homo sapiens

<400>  1954
ctggtctcga actcccgacc tcaggtgatc tgactgcctc agtctcccaa agtgctggga     60

ttacagattt taaaatggaa attatcaagg aaacaaagac agtttcacgc tcaaatagga    120

aaatgtcctt gctcaaaaga actcttgtaa ggaagccatc aatgagaccc agaaacttga    180

cagaagtcct cttaaataca cagcacttgg agttcttcag ggagttcctc aaggaacgga    240

aggctaaaat cccattgcaa tttctcacag ctgtacagaa gatcagtata gagaccaatg    300

aaaagatttg caagtctctc atagaaaatg taatcaagac tttcttccaa ggccaactct    360

ctcctgaaga aatgctgcag tgtgatgccc ctattatcaa agaaatcgct tccatgcgtc    420

atgtcaccac aagcacactg ttaacgctcc agggacatgt tatgaaatct atagaagaaa    480

agtgaagaaa ggctggatga gaatgatcag ctttatcagg agtttttgca agtaccgcag    540

atttatgttg aatcctagta agcgccagga atttgaagac tatcttcacc aggaaatgca    600

aaatagcaag gaaa                                                      614


<210>  1955
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  1955

Met Glu Ile Ile Lys Glu Thr Lys Thr Val Ser Arg Ser Asn Arg Lys 
1               5                   10                  15


Met Ser Leu Leu Lys Arg Thr Leu Val Arg Lys Pro Ser Met Arg Pro 
            20                  25                  30


Arg Asn Leu Thr Glu Val Leu Leu Asn Thr Gln His Leu Glu Phe Phe 
        35                  40                  45


Arg Glu Phe Leu Lys Glu Arg Lys Ala Lys Ile Pro Leu Gln Phe Leu 
    50                  55                  60


Thr Ala Val Gln Lys Ile Ser Ile Glu Thr Asn Glu Lys Ile Cys Lys 
65                  70                  75                  80


Ser Leu Ile Glu Asn Val Ile Lys Thr Phe Phe Gln Gly Gln Leu Ser 
                85                  90                  95


Pro Glu Glu Met Leu Gln Cys Asp Ala Pro Ile Ile Lys Glu Ile Ala 
            100                 105                 110


Ser Met Arg His Val Thr Thr Ser Thr Leu Leu Thr Leu Gln Gly His 
        115                 120                 125


Val Met Lys Ser Ile Glu Glu Lys 
    130                 135


<210>  1956
<211>  2686
<212>  DNA
<213>  Homo sapiens

<400>  1956
taatttttgg acagagacga gacaggctta gagatattga ctgaggacta aagagtccct     60

ggctttgatt tctggttgct gaattgtgct ctagaaagca ctactgctta ccctaagtcc    120

aactaagagt ttgaggtgtc agcttcagca atcaccaagc aagcctttct gtgaatttta    180

tgcagttttc catcagagtt ctggctagaa tttgtactat gctttggttt gttgattttt    240

tttcttactc tttttttttc tttttgtctt ttagtagaaa cttctcagaa gatgtgctgg    300

ggtggagaga gtcgttcgac ctgctgctga gcagtaaaag tgagtaggag ccttttgtgt    360

ctgtctctgg gtggcacatg tgtactcatg tgctttggag ccagccccag gactgctgag    420

agcctgggca gaataatagt agtagtaata ataataataa tgatccccta gtgtgccagc    480

ctctattcaa catataaagg caggtcattg ttcaagaaaa ttatgttcta aaaatagagc    540

cattaattgc aattgctttc ctttcttctt gtattccctg ctgtccctcc agctgaccta    600

tttcctcttc tttcccgcaa ccccagatgg agtggctgcc ttccacgctt tcctgaagac    660

agagttcagt gaggagaacc tggagttctg gctggcctgt gaggagttca agaagatccg    720

atcagctacc aagctggcct ccagggcaca ccagatcttt gaggagttca tttgcagtga    780

ggcccctaaa gaggtcaaca ttgaccatga gacccacgag ctgacgagga tgaacctgca    840

gactgccaca gccacatgct ttgatgcggc tcaggggaag acacgtaccc tgatggagaa    900

ggactcctac ccacgcttcc tgaagtcgcc tgcttaccgg gacctggctg cccaagcctc    960

agccgcctct gccactctgt ccagctgcag cctggacgag ccctcacaca cctgagtctc   1020

cacggcagtg aggaagccag ccgggaagag aggttgagtc acccatcccc gaggtggctg   1080

cccctgtgtg ggaggcaggt tctgcaaagc aagtgcaaga ggacaaaaaa aaaaaaaaaa   1140

aaaaaaaaaa tgcgctccag cagcctgttt gggaagcagc agtctctcct tcagatactg   1200

tgggactcat gctggagagg agccgcccac ttccaggacc tgtgaataag ggctaatgat   1260

gagggttggt ggggctctct gtggggcaaa aaggtggtat gggggttagc actggctctc   1320

gttctcaccg gagaaggaag tgttctagtg tggtttagga aacatgtgga taaagggaac   1380

catgaaaatg agaggaggaa agacatccag atcagctgtt ttgcctgttg ctcagttgac   1440

tctgattgca tcctgttttc ctaattccca gactgttctg ggcacggaag ggaccctgga   1500

tgtggagtct tcccctttgg ccctcctcac tggcctctgg gctagcccag agtcccttag   1560

cttgtacctc gtaacactcc tgtgtgtctg tccagccttg cagtcatgtc aaggccagca   1620

agctgatgtg actcttgccc catgcgagat atttatacct caaacactgg cctgtgagcc   1680

ctttccaagt cagtggagag ccctgaaagg aggctcactt gaatccagct cagtgctctg   1740

ggtggccccc tgcaggtggc ccctgaccct gcgttgcagc agggtccacc tgtgagcagg   1800

cccgccctgg ggcctcttcc tggatgtgcc ctctctgagt tctgtgctgt ctcttggagg   1860

cagggcccag gagaacaaag tgtggaggcc tcggggagtg gcttttccag ctctcatgcc   1920

ccgcagtgtg gaacaaggca gaaaaggatc ctaggaaata agtctcttgg cggtccctga   1980

gagtcctgct gaaatccagc cagtgttttt tgtggtatga gaacaggcaa aaagagatgc   2040

cccgagatag aaggggagcc ttgtgtttct ttcctgcaga cgtgagatga acactggagt   2100

gggcagaggt ggcccaggac catggcaccc ttagagtgca gaagctgggg ggagaggctg   2160

cttcgaaggg caggactggg gataatcaga acctgcctgt cacctcaggg catcactgaa   2220

caaacatttc ctgatggcaa ctcctgcggc agagcccagg ctggggaagt gaactaccca   2280

gggcagcccc tttgtggccc aggataatca acactgttct ctctgtacca tgagctcctc   2340

caggagatta tttaagtgta ttgtatcatt ggttttctgt gattgtcata acattgtttt   2400

tgttattgtt ggtgctgttg ttatttatta ttgtaatttc agtttgcctc tactggagaa   2460

tctcagcagg ggtttcagcc tgactgtctc cctttctcta ccagactcta cctctgaatg   2520

tgctgggaac ctcttggagc ctgtcaggaa ctcctcactg tttaaatatt tatttattgt   2580

gacaaatgga gctggtttcc tagatatgaa tgatgtttgc aatccccatt ttcctgtttc   2640

agcatgttat attcttataa aataaaagca aaagtcaaat atgaca                  2686


<210>  1957
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  1957

Met Trp Ile Lys Gly Thr Met Lys Met Arg Gly Gly Lys Thr Ser Arg 
1               5                   10                  15


Ser Ala Val Leu Pro Val Ala Gln Leu Thr Leu Ile Ala Ser Cys Phe 
            20                  25                  30


Pro Asn Ser Gln Thr Val Leu Gly Thr Glu Gly Thr Leu Asp Val Glu 
        35                  40                  45


Ser Ser Pro Leu Ala Leu Leu Thr Gly Leu Trp Ala Ser Pro Glu Ser 
    50                  55                  60


Leu Ser Leu Tyr Leu Val Thr Leu Leu Cys Val Cys Pro Ala Leu Gln 
65                  70                  75                  80


Ser Cys Gln Gly Gln Gln Ala Asp Val Thr Leu Ala Pro Cys Glu Ile 
                85                  90                  95


Phe Ile Pro Gln Thr Leu Ala Cys Glu Pro Phe Pro Ser Gln Trp Arg 
            100                 105                 110


Ala Leu Lys Gly Gly Ser Leu Glu Ser Ser Ser Val Leu Trp Val Ala 
        115                 120                 125


Pro Cys Arg Trp Pro Leu Thr Leu Arg Cys Ser Arg Val His Leu 
    130                 135                 140


<210>  1958
<211>  2436
<212>  DNA
<213>  Homo sapiens

<400>  1958
gtacaaaaca aatctttgag agtcagggga attgaaataa tttttggaca gagacgagac     60

aggcttagag atattgactg aggactaaag agtccctggc tttgatttct ggttgctgaa    120

ttgtgctcta gaaagcacta ctgcttaccc taagtccaac taagagtttg aggtgtcagc    180

ttcagcaatc accaagcaag cctttctgtg aattttatgc agttttccat cagagttctg    240

gctagaattt gtactatgct ttggtttgtt gatttttttt cttactcttt ttttttcttt    300

ttgtctttta gtagaaactt ctcagaagat gtgctggggt ggagagagtc gttcgacctg    360

ctgctgagca gtaaaaatgg agtggctgcc ttccacgctt tcctgaagac agagttcagt    420

gaggagaacc tggagttctg gctggcctgt gaggagttca agaagatccg atcagctacc    480

aagctggcct ccagggcaca ccagatcttt gaggagttca tttgcagtga ggcccctaaa    540

gaggtcaaca ttgaccatga gacccacgag ctgacgagga tgaacctgca gactgccaca    600

gccacatgct ttgatgcggc tcaggggaag acacgtaccc tgatggagaa ggactcctac    660

ccacgcttcc tgaagtcgcc tgcttaccgg gacctggctg cccaagcctc agccgcctct    720

gccactctgt ccagctgcag cctggacgag ccctcacaca cctgagtctc cacggcagtg    780

aggaagccag ccgggaagag aggttgagtc acccatcccc gaggtggctg cccctgtgtg    840

ggaggcaggt tctgcaaagc aagtgcaaga ggacaaaaaa aaaaaaaaaa aaaaaaaaaa    900

tgcgctccag cagcctgttt gggaagcagc agtctctcct tcagatactg tgggactcat    960

gctggagagg agccgcccac ttccaggacc tgtgaataag ggctaatgat gagggttggt   1020

ggggctctct gtggggcaaa aaggtggtat gggggttagc actggctctc gttctcaccg   1080

gagaaggaag tgttctagtg tggtttagga aacatgtgga taaagggaac catgaaaatg   1140

agaggaggaa agacatccag atcagctgtt ttgcctgttg ctcagttgac tctgattgca   1200

tcctgttttc ctaattccca gactgttctg ggcacggaag ggaccctgga tgtggagtct   1260

tcccctttgg ccctcctcac tggcctctgg gctagcccag agtcccttag cttgtacctc   1320

gtaacactcc tgtgtgtctg tccagccttg cagtcatgtc aaggccagca agctgatgtg   1380

actcttgccc catgcgagat atttatacct caaacactgg cctgtgagcc ctttccaagt   1440

cagtggagag ccctgaaagg aggctcactt gaatccagct cagtgctctg ggtggccccc   1500

tgcaggtggc ccctgaccct gcgttgcagc agggtccacc tgtgagcagg cccgccctgg   1560

ggcctcttcc tggatgtgcc ctctctgagt tctgtgctgt ctcttggagg cagggcccag   1620

gagaacaaag tgtggaggcc tcggggagtg gcttttccag ctctcatgcc ccgcagtgtg   1680

gaacaaggca gaaaaggatc ctaggaaata agtctcttgg cggtccctga gagtcctgct   1740

gaaatccagc cagtgttttt tgtggtatga gaacaggcaa aaagagatgc cccgagatag   1800

aaggggagcc ttgtgtttct ttcctgcaga cgtgagatga acactggagt gggcagaggt   1860

ggcccaggac catggcaccc ttagagtgca gaagctgggg ggagaggctg cttcgaaggg   1920

caggactggg gataatcaga acctgcctgt cacctcaggg catcactgaa caaacatttc   1980

ctgatggcaa ctcctgcggc agagcccagg ctggggaagt gaactaccca gggcagcccc   2040

tttgtggccc aggataatca acactgttct ctctgtacca tgagctcctc caggagatta   2100

tttaagtgta ttgtatcatt ggttttctgt gattgtcata acattgtttt tgttattgtt   2160

ggtgctgttg ttatttatta ttgtaatttc agtttgcctc tactggagaa tctcagcagg   2220

ggtttcagcc tgactgtctc cctttctcta ccagactcta cctctgaatg tgctgggaac   2280

ctcttggagc ctgtcaggaa ctcctcactg tttaaatatt tatttattgt gacaaatgga   2340

gctggtttcc tagatatgaa tgatgtttgc aatccccatt ttcctgtttc agcatgttat   2400

attcttataa aataaaagca aaagtcaaat atgaca                             2436


<210>  1959
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  1959

Met Gln Phe Ser Ile Arg Val Leu Ala Arg Ile Cys Thr Met Leu Trp 
1               5                   10                  15


Phe Val Asp Phe Phe Ser Tyr Ser Phe Phe Phe Phe Leu Ser Phe Ser 
            20                  25                  30


Arg Asn Phe Ser Glu Asp Val Leu Gly Trp Arg Glu Ser Phe Asp Leu 
        35                  40                  45


Leu Leu Ser Ser Lys Asn Gly Val Ala Ala Phe His Ala Phe Leu Lys 
    50                  55                  60


Thr Glu Phe Ser Glu Glu Asn Leu Glu Phe Trp Leu Ala Cys Glu Glu 
65                  70                  75                  80


Phe Lys Lys Ile Arg Ser Ala Thr Lys Leu Ala Ser Arg Ala His Gln 
                85                  90                  95


Ile Phe Glu Glu Phe Ile Cys Ser Glu Ala Pro Lys Glu Val Asn Ile 
            100                 105                 110


Asp His Glu Thr His Glu Leu Thr Arg Met Asn Leu Gln Thr Ala Thr 
        115                 120                 125


Ala Thr Cys Phe Asp Ala Ala Gln Gly Lys Thr Arg Thr Leu Met Glu 
    130                 135                 140


Lys Asp Ser Tyr Pro Arg Phe Leu Lys Ser Pro Ala Tyr Arg Asp Leu 
145                 150                 155                 160


Ala Ala Gln Ala Ser Ala Ala Ser Ala Thr Leu Ser Ser Cys Ser Leu 
                165                 170                 175


Asp Glu Pro Ser His Thr 
            180


<210>  1960
<211>  2936
<212>  DNA
<213>  Homo sapiens

<400>  1960
ataaaatgga gatgatgatg aagagcttac ttagccccgt gtccatcatg gtaagagcct     60

cgtaaagggt acttatcagt ataatcagat gctgttttgc ccaggtttgc accctgtgcg    120

cctgtcctca ggacccagca ggctcagact tgcctgcgat caaagaaagc cctgtgtgcc    180

tcccagaccc accacccccg tgcaaactct ctcaacacga caccgctgcg tgactttcct    240

gctgttacta gaggtcggca ggtacttttc cctaggaaac tgggtgtgca cgtctcatcc    300

ccgtgccaat tctcttgccg cttttccttc cacacgcggc gtcctctggg cggagggtgc    360

agctccgcgt gctccagctg ccgcgaaagt tgcacccggc ccagtctggc tgcgggcccc    420

gcctccgcct tctcagcgcc cagccccacc ctccgattgg tcagcagtgc ccagccccgc    480

cccgctcctc cgaggggatt taaagcagcg gccgctcagt ctgggcgctt gcaggctgct    540

aaacccaacc gcagttgact agcacctgct accgcgcctt tgcttcctgg cgcacgcgga    600

gcctcctgga gcctgccacc atcctgccta ctacgtgctg ccctgcgccc gcagccatgt    660

gccgcaccct ggccgccttc cccaccacct gcctggagag agccaaagag ttcaagacac    720

gtctggggat ctttcttcac aaatcagagc tgggctgcga tactgggagt actggcaagt    780

tcgagtgggg cagtaaacac agcaaagaga atagaaactt ctcagaagat gtgctggggt    840

ggagagagtc gttcgacctg ctgctgagca gtaaaaatgg agtggctgcc ttccacgctt    900

tcctgaagac agagttcagt gaggagaacc tggagttctg gctggcctgt gaggagttca    960

agaagatccg atcagctacc aagctggcct ccagggcaca ccagatcttt gaggagttca   1020

tttgcagtga ggcccctaaa gaggtcaaca ttgaccatga gacccacgag ctgacgagga   1080

tgaacctgca gactgccaca gccacatgct ttgatgcggc tcaggggaag acacgtaccc   1140

tgatggagaa ggactcctac ccacgcttcc tgaagtcgcc tgcttaccgg gacctggctg   1200

cccaagcctc agccgcctct gccactctgt ccagctgcag cctggacgag ccctcacaca   1260

cctgagtctc cacggcagtg aggaagccag ccgggaagag aggttgagtc acccatcccc   1320

gaggtggctg cccctgtgtg ggaggcaggt tctgcaaagc aagtgcaaga ggacaaaaaa   1380

aaaaaaaaaa aaaaaaaaaa tgcgctccag cagcctgttt gggaagcagc agtctctcct   1440

tcagatactg tgggactcat gctggagagg agccgcccac ttccaggacc tgtgaataag   1500

ggctaatgat gagggttggt ggggctctct gtggggcaaa aaggtggtat gggggttagc   1560

actggctctc gttctcaccg gagaaggaag tgttctagtg tggtttagga aacatgtgga   1620

taaagggaac catgaaaatg agaggaggaa agacatccag atcagctgtt ttgcctgttg   1680

ctcagttgac tctgattgca tcctgttttc ctaattccca gactgttctg ggcacggaag   1740

ggaccctgga tgtggagtct tcccctttgg ccctcctcac tggcctctgg gctagcccag   1800

agtcccttag cttgtacctc gtaacactcc tgtgtgtctg tccagccttg cagtcatgtc   1860

aaggccagca agctgatgtg actcttgccc catgcgagat atttatacct caaacactgg   1920

cctgtgagcc ctttccaagt cagtggagag ccctgaaagg aggctcactt gaatccagct   1980

cagtgctctg ggtggccccc tgcaggtggc ccctgaccct gcgttgcagc agggtccacc   2040

tgtgagcagg cccgccctgg ggcctcttcc tggatgtgcc ctctctgagt tctgtgctgt   2100

ctcttggagg cagggcccag gagaacaaag tgtggaggcc tcggggagtg gcttttccag   2160

ctctcatgcc ccgcagtgtg gaacaaggca gaaaaggatc ctaggaaata agtctcttgg   2220

cggtccctga gagtcctgct gaaatccagc cagtgttttt tgtggtatga gaacaggcaa   2280

aaagagatgc cccgagatag aaggggagcc ttgtgtttct ttcctgcaga cgtgagatga   2340

acactggagt gggcagaggt ggcccaggac catggcaccc ttagagtgca gaagctgggg   2400

ggagaggctg cttcgaaggg caggactggg gataatcaga acctgcctgt cacctcaggg   2460

catcactgaa caaacatttc ctgatggcaa ctcctgcggc agagcccagg ctggggaagt   2520

gaactaccca gggcagcccc tttgtggccc aggataatca acactgttct ctctgtacca   2580

tgagctcctc caggagatta tttaagtgta ttgtatcatt ggttttctgt gattgtcata   2640

acattgtttt tgttattgtt ggtgctgttg ttatttatta ttgtaatttc agtttgcctc   2700

tactggagaa tctcagcagg ggtttcagcc tgactgtctc cctttctcta ccagactcta   2760

cctctgaatg tgctgggaac ctcttggagc ctgtcaggaa ctcctcactg tttaaatatt   2820

tatttattgt gacaaatgga gctggtttcc tagatatgaa tgatgtttgc aatccccatt   2880

ttcctgtttc agcatgttat attcttataa aataaaagca aaagtcaaat atgaca       2936


<210>  1961
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  1961

Met Cys Arg Thr Leu Ala Ala Phe Pro Thr Thr Cys Leu Glu Arg Ala 
1               5                   10                  15


Lys Glu Phe Lys Thr Arg Leu Gly Ile Phe Leu His Lys Ser Glu Leu 
            20                  25                  30


Gly Cys Asp Thr Gly Ser Thr Gly Lys Phe Glu Trp Gly Ser Lys His 
        35                  40                  45


Ser Lys Glu Asn Arg Asn Phe Ser Glu Asp Val Leu Gly Trp Arg Glu 
    50                  55                  60


Ser Phe Asp Leu Leu Leu Ser Ser Lys Asn Gly Val Ala Ala Phe His 
65                  70                  75                  80


Ala Phe Leu Lys Thr Glu Phe Ser Glu Glu Asn Leu Glu Phe Trp Leu 
                85                  90                  95


Ala Cys Glu Glu Phe Lys Lys Ile Arg Ser Ala Thr Lys Leu Ala Ser 
            100                 105                 110


Arg Ala His Gln Ile Phe Glu Glu Phe Ile Cys Ser Glu Ala Pro Lys 
        115                 120                 125


Glu Val Asn Ile Asp His Glu Thr His Glu Leu Thr Arg Met Asn Leu 
    130                 135                 140


Gln Thr Ala Thr Ala Thr Cys Phe Asp Ala Ala Gln Gly Lys Thr Arg 
145                 150                 155                 160


Thr Leu Met Glu Lys Asp Ser Tyr Pro Arg Phe Leu Lys Ser Pro Ala 
                165                 170                 175


Tyr Arg Asp Leu Ala Ala Gln Ala Ser Ala Ala Ser Ala Thr Leu Ser 
            180                 185                 190


Ser Cys Ser Leu Asp Glu Pro Ser His Thr 
        195                 200


<210>  1962
<211>  1374
<212>  DNA
<213>  Homo sapiens

<400>  1962
ataaaatgga gatgatgatg aagagcttac ttagccccgt gtccatcatg gtaagagcct     60

cgtaaagggt acttatcagt ataatcagat gctgttttgc ccaggtttgc accctgtgcg    120

cctgtcctca ggacccagca ggctcagact tgcctgcgat caaagaaagc cctgtgtgcc    180

tcccagaccc accacccccg tgcaaactct ctcaacacga caccgctgcg tgactttcct    240

gctgttacta gaggtcggca ggtacttttc cctaggaaac tgggtgtgca cgtctcatcc    300

ccgtgccaat tctcttgccg cttttccttc cacacgcggc gtcctctggg cggagggtgc    360

agctccgcgt gctccagctg ccgcgaaagt tgcacccggc ccagtctggc tgcgggcccc    420

gcctccgcct tctcagcgcc cagccccacc ctccgattgg tcagcagtgc ccagccccgc    480

cccgctcctc cgaggggatt taaagcagcg gccgctcagt ctgggcgctt gcaggctgct    540

aaacccaacc gcagttgact agcacctgct accgcgcctt tgcttcctgg cgcacgcgga    600

gcctcctgga gcctgccacc atcctgccta ctacgtgctg ccctgcgccc gcagccatgt    660

gccgcaccct ggccgccttc cccaccacct gcctggagag agccaaagag ttcaagacac    720

gtctggggat ctttcttcac aaatcagagc tgggctgcga tactgggagt actggcaagt    780

tcgagtgggg cagtaaacac agcaaagaga atagaaactt ctcagaagat gtgctggggt    840

ggagagagtc gttcgacctg ctgctgagca gtaaaaatgg agtggctgcc ttccacgctt    900

tcctgaagac agagttcagt gaggagaacc tggagttctg gctggcctgt gaggagttca    960

agaagatccg atcagctacc aagctggcct ccagggcaca ccagatcttt gaggagttca   1020

tttgcagtga ggcccctaaa gaggtcaaca ttgaccatga gacccacgag ctgacgagga   1080

tgaacctgca gactgccaca gccacatgct ttgatgcggc tcaggggaag acacgtaccc   1140

tgatggagaa ggactcctac ccacgcttcc tgaagtcgcc tgcttaccgg gacctggctg   1200

cccaagcctc agccgcctct gccactctgt ccagctgcag cctggacgag ccctcacaca   1260

cctgagtctc cacggcagtg aggaagccag ccgggaagag aggttgagtc acccatcccc   1320

gaggtggctg cccctgtgtg ggaggcaggt tctgcaaagc aagtgcaaga ggac         1374


<210>  1963
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  1963

Met Cys Arg Thr Leu Ala Ala Phe Pro Thr Thr Cys Leu Glu Arg Ala 
1               5                   10                  15


Lys Glu Phe Lys Thr Arg Leu Gly Ile Phe Leu His Lys Ser Glu Leu 
            20                  25                  30


Gly Cys Asp Thr Gly Ser Thr Gly Lys Phe Glu Trp Gly Ser Lys His 
        35                  40                  45


Ser Lys Glu Asn Arg Asn Phe Ser Glu Asp Val Leu Gly Trp Arg Glu 
    50                  55                  60


Ser Phe Asp Leu Leu Leu Ser Ser Lys Asn Gly Val Ala Ala Phe His 
65                  70                  75                  80


Ala Phe Leu Lys Thr Glu Phe Ser Glu Glu Asn Leu Glu Phe Trp Leu 
                85                  90                  95


Ala Cys Glu Glu Phe Lys Lys Ile Arg Ser Ala Thr Lys Leu Ala Ser 
            100                 105                 110


Arg Ala His Gln Ile Phe Glu Glu Phe Ile Cys Ser Glu Ala Pro Lys 
        115                 120                 125


Glu Val Asn Ile Asp His Glu Thr His Glu Leu Thr Arg Met Asn Leu 
    130                 135                 140


Gln Thr Ala Thr Ala Thr Cys Phe Asp Ala Ala Gln Gly Lys Thr Arg 
145                 150                 155                 160


Thr Leu Met Glu Lys Asp Ser Tyr Pro Arg Phe Leu Lys Ser Pro Ala 
                165                 170                 175


Tyr Arg Asp Leu Ala Ala Gln Ala Ser Ala Ala Ser Ala Thr Leu Ser 
            180                 185                 190


Ser Cys Ser Leu Asp Glu Pro Ser His Thr 
        195                 200


<210>  1964
<211>  882
<212>  DNA
<213>  Homo sapiens

<400>  1964
gcttgcaggc tgctaaaccc aaccgcagtt gactagcacc tgctaccgcg cctttgcttc     60

ctggcgcacg cggagcctcc tggagcctgc caccatcctg cctactacgt gctgccctgc    120

gcccgcagcc atgtgccgca ccctggccgc cttccccacc acctgcctgg agagagccaa    180

agagttcaag acacgtctgg ggatctttct tcacaaatca gagctgggct gcgatactgg    240

gagtactggc aagttcgagt ggggcagtaa acacagcaaa gagaatagaa acttctcaga    300

agatgtgctg gggtggagag agtcgttcga cctgctgctg agcagtaaaa gtgagtagga    360

gccttttgtg tctgtctctg ggtggcacat gtgtactcat gtgctttgga gccagcccca    420

ggactgctga gagcctgggc agaataatag tagtagtaat aataataata atgatcccct    480

agtgtgccag cctctattca acatataaag gcaggtcatt gttcaagaaa attatgttct    540

aaaaatagag ccattaattg caattgcttt cctttcttct tgtattccct gctgtccctc    600

cagctgacct atttcctctt ctttcccgca accccagatg gagtggctgc cttccacgct    660

ttcctgaaga cagagttcag tgaggagaac ctggagttct ggctggcctg tgaggagttc    720

aagaagatcc gatcagctac caagctggcc tccagggcac accagatctt tgaggagttc    780

atttgcagtg aggcccctaa agaggttaga gcccccatat gcccagtgaa tcctcacgac    840

cctgcctgct ccttcccctc tgagaatcag ggctagaggg ga                       882


<210>  1965
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  1965

Met Cys Arg Thr Leu Ala Ala Phe Pro Thr Thr Cys Leu Glu Arg Ala 
1               5                   10                  15


Lys Glu Phe Lys Thr Arg Leu Gly Ile Phe Leu His Lys Ser Glu Leu 
            20                  25                  30


Gly Cys Asp Thr Gly Ser Thr Gly Lys Phe Glu Trp Gly Ser Lys His 
        35                  40                  45


Ser Lys Glu Asn Arg Asn Phe Ser Glu Asp Val Leu Gly Trp Arg Glu 
    50                  55                  60


Ser Phe Asp Leu Leu Leu Ser Ser Lys Ser Glu 
65                  70                  75


<210>  1966
<211>  604
<212>  DNA
<213>  Homo sapiens

<400>  1966
gcttgcaggc tgctaaaccc aaccgcagtt gactagcacc tgctaccgcg cctttgcttc     60

ctggcgcacg cggagcctcc tggagcctgc caccatcctg cctactacgt gctgccctgc    120

gcccgcagcc atgtgccgca ccctggccgc cttccccacc acctgcctgg agagagccaa    180

agagttcaag acacgtctgg ggatctttct tcacaaatca gagctgggct gcgatactgg    240

gagtactggc aagttcgagt ggggcagtaa acacagcaaa gagaagtaag tgttgctgac    300

cagctcaggg ctccgagagg gaagggagtg ggaagggagt catgaggagg gaaatacagg    360

gagaagccag gacacgctaa gtggaccttg gcaacacctc cctagagatt ttagtgggac    420

ttgttgctgg tctgttatga ctacttggct catgggtgag tgggtaggtg gctccagggc    480

tccaagtcca tccacggatg agggcacaca gggcatgaat gcctagttcc cagactctcc    540

cacctcggga ttcattgcac gtgcatccag ggctaggaca gaatccaaga ccacttgaag    600

tttt                                                                 604


<210>  1967
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  1967

Met Cys Arg Thr Leu Ala Ala Phe Pro Thr Thr Cys Leu Glu Arg Ala 
1               5                   10                  15


Lys Glu Phe Lys Thr Arg Leu Gly Ile Phe Leu His Lys Ser Glu Leu 
            20                  25                  30


Gly Cys Asp Thr Gly Ser Thr Gly Lys Phe Glu Trp Gly Ser Lys His 
        35                  40                  45


Ser Lys Glu Lys 
    50


<210>  1968
<211>  403
<212>  DNA
<213>  Homo sapiens

<400>  1968
cgcgtctgga gtttcttcct tctggtgggt tcgtgatctc gctggctcag gagtgaagct     60

gcagaccttc acggagattg taaaatcagg aagtatatct aagtcacctc cagtagccgt    120

aactctacct tgtccagtaa aagtgctgct tgttgctgac gtttctgccc aaacatcatg    180

aaatgtggag aagaaagaac actcagatgt gccctggaga ctttcctttt atttttaaac    240

agtttttttt tccattgggt ttgaccaact ctatattcga cttgaacaaa tccgaaggaa    300

agcttccaat tatggggaac aagtcctctg aagtggctaa attcccacac acacaaaaga    360

aaaggtaggg tggtgggggg gagaaaaaca gccagcaaaa gga                      403


<210>  1969
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  1969

Met Trp Arg Arg Lys Asn Thr Gln Met Cys Pro Gly Asp Phe Pro Phe 
1               5                   10                  15


Ile Phe Lys Gln Phe Phe Phe Pro Leu Gly Leu Thr Asn Ser Ile Phe 
            20                  25                  30


Asp Leu Asn Lys Ser Glu Gly Lys Leu Pro Ile Met Gly Asn Lys Ser 
        35                  40                  45


Ser Glu Val Ala Lys Phe Pro His Thr Gln Lys Lys Arg 
    50                  55                  60


<210>  1970
<211>  796
<212>  DNA
<213>  Homo sapiens

<400>  1970
cgggctggtc tcaaacttct ggacacaaac aatcctccac attggcctcc caaaatgctg     60

gaattacagg tgtgagccac tggaccagca ggactctaaa ttttggtgct caaaaaacat    120

ttgttgagta agtgaacctg agactatcaa caagcattat tttaaaatca ctagcaaagg    180

agattgtaaa atcaggaagt atatctaagt cacctccagt agccgtaact ctaccttgtc    240

cagtaaaagg acagtgtaca aatcatgaat tcaaataacc accatgcagg tcaagaagat    300

aaaatcagca gcacattcca ggtcaccctc ttgtctctac catcccttct catctctcca    360

aatatgacca ataaccttag ttttgtcagt gtttggaatt tgtataaatg tgattgtaca    420

gaatgtaccc tttcgtatct ggtttctttc agtcaatact atgcctattt tatttattca    480

tgttaatgaa tggaaaaata gttcatttat tttaacttct gtttggcatt ccgttgtgtg    540

atcattctac aatatatgta ttttacctat agctggtggg ctttgtgcgg cttccagaat    600

agtaatgtta tatatagtgc tattatattc atttttgtat gaatacaaat ggtacctttg    660

ttttgttttg aataggaggg gatttactag ataaatgggt tatgggtgtt ttcaactttg    720

acagacccta aaagtttctc aaagtaatag taccaaatta ccttctcacc aggaatataa    780

gaggtctatt tttttc                                                    796


<210>  1971
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  1971

Met Asn Ser Asn Asn His His Ala Gly Gln Glu Asp Lys Ile Ser Ser 
1               5                   10                  15


Thr Phe Gln Val Thr Leu Leu Ser Leu Pro Ser Leu Leu Ile Ser Pro 
            20                  25                  30


Asn Met Thr Asn Asn Leu Ser Phe Val Ser Val Trp Asn Leu Tyr Lys 
        35                  40                  45


Cys Asp Cys Thr Glu Cys Thr Leu Ser Tyr Leu Val Ser Phe Ser Gln 
    50                  55                  60


Tyr Tyr Ala Tyr Phe Ile Tyr Ser Cys 
65                  70


<210>  1972
<211>  2204
<212>  DNA
<213>  Homo sapiens

<400>  1972
tatacttctc tctttcacca gtctttaatt tgcaaaaagg attattaata tcaaaacctg     60

caattacgtt tgtaccaacc taatatttaa acgacatcac ttaatctgca tttatcaaga    120

agtactcagc atttcaaggc cttctcctcg acaatgccgc agaaactact catcaaatta    180

agcaatgaat tccacataga tatagccaaa ggttgcaatc cttgtgtggc cctgcctgga    240

agccttctct cattcagagc tagtagatac aggaagaaga gtgaaggaag aggaggagtg    300

aaaataggca tggaagcctc taagcctcca ggtactggga gcagagagag aggtcaatta    360

tacaaacacg gaaagaccag aaacagactg gaagaaaata tttgcaaaac atgtgtcagg    420

aaaaggttgt gtatcctata tatataacta atttttgaac tcatttgtaa gataatcaac    480

ctgattaaaa agaaatgtgc aaaaatgtga gcagcatttc accaaatatg gtgtgtgtgt    540

gtgtgtgtgt gtgtgtgtgt atgtgtgtgt gatgcataag catgtggaaa tatacccaac    600

attgttaatc atttgagaaa tacaaactaa accataagaa tacaccatca catagttgtt    660

aagatggcta aaattacaaa gtttgctaat acccagggtt gttaaaagtg tggatcaact    720

ggacctctca ttcattgttg gtgggaatat aaaatgctac aatcaactgg gaaataaata    780

gttcagcagt ttcctattaa gttaaagata cacttataaa cagtcagtga ttcaactccc    840

agatatttac ccagcagata tgaaaaatat ccatacaaag cttatatccg cacaaaactt    900

acactcccca taatggaaaa aaaggatctc tgctttagat ctagttgtta gagaaagtct    960

gtataagaat gctttaactt aaagcttgat tggaaggaag aagaaagcca tgccaaatct   1020

aggaaaaata ttaaacacta aacaagtagc tggcacaaaa gctctaagat agtaacaaaa   1080

gtggctagaa agaaagctaa tatttcttta gaagaatgag ctaatataat tatggcaggc   1140

agtgaaattt tcaagaaata tggaagccat accaaagaaa attctaaagc ccagttgtag   1200

aattaaaaat caaccatcag tattttccaa caacagtgta actaaaaata ttataagcaa   1260

cagacaacag tattctgact tcacaaatat ccagattgtg tgtttatatt ataattcctt   1320

ctctatgtat accatgtaaa acctccatgt atcttaaaag acagtgatgt taatatcaat   1380

actggcagaa ataacttgac tggtatataa ttaattgtcc aatctacctg ggcctggtgg   1440

ctcacacctg taatcccagc actttgggag gctgaggcag gtagattact tgagcccagg   1500

aattcaagac cagtctgggc aacatgacta aaccccgttt ctacaaaaat tacaaaaatt   1560

agcctagctc ggcatggtgg tgcatgcttg tagttccagc tactcaggag attgaggtgg   1620

aaaaatcaac tgagcccagg aagttgaagc tataatgagt catgattgct ctactgtact   1680

tcaccttgaa caacagagtg ataacctgtc tcaaaaaaaa aattggtcaa tctaatgcca   1740

cattatattt tgctttatat ttggggtata ttttatttca tagtttatta tttttccctt   1800

catgagttct aatagttttc tcctcgacct aaggttaatc cacttttacc atatgcttat   1860

catctagtgc atagaacctc cctgtttgtc aaagcactct aattgttgct ttttattcat   1920

ttcagaatga atgttttcta tatgcctgct gcaatgcata tcttttcctg ttacttattt   1980

tccttgaact catggattag agtttctctt ctatattttt tgtttgcaat tttcttcctt   2040

atttgttata attcaccttc aattaacttg tttggctaaa gtatatgaaa acaaaacctt   2100

tggaattctt gcacatgcaa aactgttact atgatgctct cacatatgtt tgtataatgt   2160

gtataattgc ttactataca tattaattaa agattcaaaa ttgc                    2204


<210>  1973
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  1973

Met Pro Gln Lys Leu Leu Ile Lys Leu Ser Asn Glu Phe His Ile Asp 
1               5                   10                  15


Ile Ala Lys Gly Cys Asn Pro Cys Val Ala Leu Pro Gly Ser Leu Leu 
            20                  25                  30


Ser Phe Arg Ala Ser Arg Tyr Arg Lys Lys Ser Glu Gly Arg Gly Gly 
        35                  40                  45


Val Lys Ile Gly Met Glu Ala Ser Lys Pro Pro Gly Thr Gly Ser Arg 
    50                  55                  60


Glu Arg Gly Gln Leu Tyr Lys His Gly Lys Thr Arg Asn Arg Leu Glu 
65                  70                  75                  80


Glu Asn Ile Cys Lys Thr Cys Val Arg Lys Arg Leu Cys Ile Leu Tyr 
                85                  90                  95


Ile 



<210>  1974
<211>  7956
<212>  DNA
<213>  Homo sapiens

<400>  1974
ccacctcggc ctcccaaagt gttgggatta cgggcatgag ccacctctcc cagcttgttc     60

ttgcattttg taagatcaca tagagtatca aaactggaaa ggacctgggc catcacttcc    120

ctgagaaaaa gtgactttct caaggtcatg cagttagtag caatgctgga actgaacgcc    180

taccccgcag atcacaacat gacccgtgaa aggacctatc ctgcaacact ttggagtttc    240

gtgccgaccc aattagtggc tttgtctttg ggaaatttac ttccccaaaa cactgggaca    300

ttgggatgga attcactcac cccaaatcat caccctggtt aaggagacta aagaatcaga    360

agacatttgt gctttgggga gcagaggccc tcagggtata gagaaggaag aagagagagg    420

ttcactgtag tcctgaagca gaaataagac ctgtggctga aggaagcctt agcaattcac    480

tccttcctct tcctgagaac tctctgtagg aagtctcacc tagcagaggc ttcacagtat    540

ttcagagaag ccaaagattg tttgcctctt tggaaactgt tatccttcca tcatgactgt    600

gtcactcctg ccactgttcc accatagaga tggcgtcctt tgcagcaaac cgtaagttat    660

aaggatgagg gaagaagagt agagggccaa aaggattcca ttttgaggaa aaactacagt    720

ttgccttgcc aggtagaaga atcaggcgcc cagacaccat gtcacaaccc tccagaactg    780

acgttggcag gaagtagaga ctttgttgcc tgtgtccccc atcctcacca tgtcttcgac    840

tcagggcaat ggggaacact ggaagtccct ggagtcagtg ggcatcagcc gcaaagagct    900

agcgatggcc gaagccctgc agatggagta tgatgccctg tcccggctcc ggcatgacaa    960

ggaggagaac agagccaagc agaacgcaga cccctctctc atcagctggg atgagcctgg   1020

ggtagacttt tacagcaagc cagcaggaag gcggaccgac ctcaagctgt tacgcggtct   1080

ctctggctct gatcctaccc ttaactacaa ctcactctcc ccacaggaag ggccgcccaa   1140

ccactctacc tcccaagggc cacagcctgg ctcagatccc tggcccaaag gctccctgtc   1200

tggagactat ctctacattt ttgatggttc agatggggga gtctcttcgt ccccaggacc   1260

aggggacata gagggctctt gcaagaaact atccccacct cctctgcctc cccgagcttc   1320

tatctgggat acccctcccc tgcctcccag aaaggggtcc ccctcatcct ccaagatctc   1380

ccagcccagt gacatcaaca ctttctcttt ggtcgaacaa ttgccgggca aactgctaga   1440

gcatcggatc ctagaagagg aagaggtgct gggaggtggg ggtcaggggc gcctactggg   1500

gtctgtggac tatgatggta tcaatgatgc aattactagg ctcaacttga aatcgaccta   1560

tgatgcggag atgttgcggg atgccaccag gggctggaag gagggccgag ggccgctgga   1620

cttcagcaaa gacacctctg gaaaacccgt ggccaggagc aagactatgc cccctcaggt   1680

gcccccccgc acctatgcct cccgctatgg caaccgaaag aatgcgacgc ctggcaagaa   1740

ccgccggatt tctgcagccc cggtgggctc ccggccccac actgttgcca atggccatga   1800

gttgtttgag gtctcagaag agagagatga ggaggttgct gcattttgcc acatgctgga   1860

tatccttcga tctggctctg acatccaaga ctacttcctc actggctatg tctggagtgc   1920

tgtcacccct agcccagagc acctcgggga tgaggtcaac ctgaaggtga ctgtgttgtg   1980

tgacaggctt caagaggcac tcactttcac ctgcaactgt tcctccactg tagacttgct   2040

tatctaccag accctgtgct acacccatga tgacctgagg aatgtggacg tgggtgactt   2100

tgtgctaaag ccctgcgggc tggaggagtt cctgcagaac aagcatgcct tgggcagtca   2160

tgagtacatc caatactgcc gcaagtttga cattgacatt cggctacagc tgatggagca   2220

gaaggttgtg cgcagtgacc tggcccggac ggtgaatgat gaccagagcc cctccacctt   2280

gaactacctc gtccatctcc aagagaggcc tgtcaagcag accatcagca ggcaggccct   2340

gagtcttctg ttcgacactt accacaatga ggtggatgcc ttcctgctgg ctgatggaga   2400

cttcccactg aaggctgaca gggtggtcca gtccgtcaag gccatctgca acgccctggc   2460

cgccgtggaa acccctgaga tcaccagtgc tctcaaccag ctgcccccct gcccctcccg   2520

catgcagcct aaaattcaga aggatcccag tgtcttggct gtgagggaaa accgagagaa   2580

ggtcgtggaa gccctgaccg ctgccatctt ggacctggtg gagctgtact gcaacacatt   2640

caacgcagac ttccagacgg cagtgcccgg gagccgcaag catgacctgg tccaggaggc   2700

ctgccatttc gccaggtccc tggccttcac tgtctatgcc acccaccgca tccccatcat   2760

ctgggctacc agctatgaag atttctacct ctcctgctcc ctcagccatg gcggcaagga   2820

gctgtgcagc cccctgcaga cccgaagagc tcacttctcc aagtacctct tccacctcat   2880

cgtctgggac cagcagatct gcttcccagt gcaggtgaac cggctgcctc gggagacact   2940

gctgtgtgcc actctctatg ctctgcccat ccccccaccg gggagctcct cagaggccaa   3000

taagcagcgg cgggtgcctg aagccctggg ctgggtcact accccactct tcaacttcag   3060

gcaggtcctg acctgtggcc ggaagcttct gggtttgtgg ccagcaacac aggaaaatcc   3120

cagcgcccgt tggagtgcac ctaatttcca ccagccagac agtgtcatcc tgcagattga   3180

cttccccacc tcggcctttg acatcaagtt caccagcccc cctggagaca agttcagccc   3240

ccgctatgag tttggcagcc tccgggaaga agaccagcgc aagcttaaag acatcatgca   3300

gaaagagtcc ttgtactggc tcactgatgc tgacaagaag cgcctgtggg agaagcgata   3360

ttactgccac tcggaggtga gctcgctccc cctggtgctc gccagcgccc ccagctggga   3420

gtgggcttgc ctgcctgaca tctatgttct cctgaagcag tggacccaca tgaaccacca   3480

ggatgccctg gggctcctgc atgccacctt cccggaccag gaggtgcgtc gtatggctgt   3540

gcagtggatt ggctcactct cagatgctga gctgctagac tacctgcccc agctggtaca   3600

ggccctgaag tatgaatgct acctggacag cccgttggtg cgcttcctcc tgaaacgagc   3660

tgtgtctgac ttgagagtga ctcactactt cttctggtta ctgaaggacg gcctcaagga   3720

ctctcagttc agcatccgct accagtatct gctggcagcc ttactgtgct gctgtggcaa   3780

ggggctgaga gaagagttta accgccagtg ctggcttgtc aatgccctgg ccaaactggc   3840

ccagcaggtc cgggaggcag ccccatctgc aaggcaggga atcctccgca cgggcctgga   3900

ggaggtgaag cagttctttg ccctcaatgg ctcgtgccgc ttgccactca gccccagtct   3960

gctggttaag ggaattgtgc ccagggactg ttcctacttc aactccaatg ctgtccccct   4020

caaactctcc ttccaaaatg tggatcccct gggtgagaac atccgtgtca tcttcaagtg   4080

tggggacgac cttcgccagg acatgctaac gctgcagatg attcgcatca tgagcaagat   4140

ctgggtccag gaggggctgg acatgcgcat ggtcatcttc cgctgcttct ccaccggccg   4200

gggcagaggg atggtggaga tgatccctaa tgctgagacc ctgcgtaaga tccaggtgga   4260

gcatggggtg accggctcgt tcaaggaccg gcccctggca gactggctgc agaaacacaa   4320

ccctggggag gacgagtatg agaaggctgt ggagaacttt atctactcct gcgctggctg   4380

ctgcgtggcc acgtacgtct tgggcatctg tgaccgacat aatgacaaca tcatgctgaa   4440

gaccactggt cacatgttcc acattgattt tggccgcttc ctgggccatg cccagatgtt   4500

tggcaacatc aagcgggacc gtgccccctt tgtcttcacc tcggacatgg cgtatgtcat   4560

caacgggggt gacaagcctt ccagccgctt ccatgatttt gttgaccttt gctgccaagc   4620

ctacaacctc attcgcaagc acacccacct cttcctcaac cttctgggcc tgatgttgtc   4680

ctgtgggatc cctgaactct cagacctgga ggacctcaag tatgtgtacg atgccctgag   4740

gcctcaggat acagaggcca atgccactac ctacttcact aggttgattg agtccagcct   4800

gggcagtgta gccacaaagc tcaatttttt catccataat ctggctcaga tgaagttcac   4860

gggctcagat gaccggctga ccctctcctt tgcctcccga acacacactc tcaagagctc   4920

tggccgaatc agtgatgttt tcctctgccg ccatgagaag atcttccacc ccaacaaagg   4980

ctatatatat gtggtaaagg tgatgcgaga gaacactcac gaggccacct acatccagcg   5040

gacctttgag gagttccagg aattacacaa taagttgcgg ctgctcttcc cttcttccca   5100

cttgcccagc ttccctagtc gcttcgtgat cggccgctcc cggggagagg cggtggccga   5160

gcggcggagg gaggagctaa acggttacat ctggcacttg atccacgcac cccctgaggt   5220

ggccgagtgt gatttggtgt acaccttctt ccacccactg ccccgggatg agaaggctat   5280

gggcaccagc ccagctccta agtcctcaga tggcacatgg gcccggcccg tcggaaaggt   5340

gggaggggag gtgaagctgt ccatctccta caaaaacaat aaactcttca tcatggtgat   5400

gcatattcgg ggcttgcaac tgctccagga tggaaatgac cctgacccct atgtgaaaat   5460

ttacctcctt cctgaccctc agaaaaccac taagaggaaa accaaagtgg cccggaaaac   5520

ctgcaatcct acctacaatg agatgttggt atatgatggg atccccaagg gtgacctgca   5580

gcagcgggag ctccagctga gcgtgctgag tgagcaggga ttctgggaga acgtcctcct   5640

cggtgaggtg aacatccgcc tgcgagagct ggacctggct caggagaaga ccggctggtt   5700

cgccctggga tctcgaagtc atggcacctt gtgagcccag cagagccacc acccagcatc   5760

ccaggctggt ggcaggagct gggggagagg actctcccct gtgagactcc tccttgtgaa   5820

gggccagggc cctgggcagg cctccagctc ggtccaggtg attctggcct ctgtggtagg   5880

aggcagggag agtaagacat gctctgctgt ctcttcctct ggagactgaa cttgggttgg   5940

ttgtgatgag cagccccttg gaggctgtga ggttgcagca aagttttaag tttaccttgt   6000

gtcaagggag caatgcttgg tttggggagt gtgtggggtg ggctgtatga agtagcattt   6060

tgggggtggg tgggtggata tcttaatttt tatttttaaa aaatgaaata gtgatgttgt   6120

cctaactggg acaggaagcc ttgcgagaag ggacgtacct atgccccaga aggcaagaga   6180

ggaagactat ttggactttt tgtatgatta aggttcttat tggacttttc cctaggtttt   6240

ttttttttgt tattgttgtt gttgtttcgt tttctagcta taggaactat ctggggaggg   6300

gcccagtggg tcctcggcca gagccctctc taaggacagg ttggggaggg ttggggaggg   6360

ctgcctgtgc tggactgagg cttgtgccac tgggcctttc tgattttgcc tccaaaggag   6420

agcgctgtga tacctacatg tgtaaggaag ggccttccgt attggggttc tgccaaggac   6480

ccgtattcag ggacccatgc tcttttgggg ggacttttcc tcttgtcttc cctactttat   6540

taggacttgc cctgaatacc attttctacc ccttgcccct ccattctcct ggcccttctg   6600

ggggtcagct ggtctctatg aatatgctgg gggtgcttcc ccataggtct ctcccttcat   6660

ttgtctctgg tgggacaaaa tactgactca gtccttagat gtagtttcac ccaagagcat   6720

cttggccctg ggaagaggtc cctaggctgc agatgctact gactgcttgc taggtagcct   6780

ctggaaagca ttccccatcc atcactcccc acttctttct gctgtgctgc ttccctccca   6840

aactccattt ctgtcaccct ttttataaga cttttcctca ttctgtgggg ccataaacct   6900

atttagtctg gagccaaagg gatgccctat ctgaaggaaa ggggcatggg gtgggggatt   6960

ccatcaaaac tgttgttttt tgccccatga tttttctttg gtcagtagga ggctggattg   7020

gagtggtgat tattcccctg gagctaagct caggagcccg aagggagaga ctgagactga   7080

ctcccttatc tcttcatatt ctttattccc taccagatgg attttttttt ttttttttgg   7140

agacggagtc tcgccctgtc gccaggctgg agtgtagtgg catgatctcg actcactgca   7200

aaatctgcct cccgggttca agcgattctc ctacctcagc ctcccgagta gctgggatta   7260

caggcatgtg ccaccacgcc aagctaattt ttgtattttt agtagagacg gggtttcacc   7320

atgttggcca ggatggtctc gatctcttga cctcgtgatc tgcctgcctt ggcctcccaa   7380

agtgctggga ttacaggcgt gagccaccat gccccgcccc agatggattt tacatttgct   7440

cttttgtgtt tcgctccaaa gggttgtctt cctcgccaaa aggagggagg gactttgaat   7500

ttgatatgaa tctttaaaac cagaattggc tggatatttc ccatgattgg gaaaagagtg   7560

aaatgaggac attctgtaaa ctgtccctcc ctaattccaa ggatcagaaa ctccccgttt   7620

tgctgactca ttccataact ggagaaagaa gctccattga ccgaagccac agggcagcat   7680

ggaagtttaa attttctcta aaattaaaat gccaaggata aagctggctg cttccaggag   7740

ggggaagagg agtggggagt gggcggtgaa acttttccag atgaacggac cataaatgtg   7800

ttactggctt tgtgcctgta gctcatttta ttatgaccta tatgctcctg atttaaagag   7860

atctgtgtac tgtttacttc ccacttccca gaatcccttg tatctccttt ctcgggaatt   7920

gtattttcta ataaatgaca tttgagaaaa aaatga                             7956


<210>  1975
<211>  1634
<212>  PRT
<213>  Homo sapiens

<400>  1975

Met Ser Ser Thr Gln Gly Asn Gly Glu His Trp Lys Ser Leu Glu Ser 
1               5                   10                  15


Val Gly Ile Ser Arg Lys Glu Leu Ala Met Ala Glu Ala Leu Gln Met 
            20                  25                  30


Glu Tyr Asp Ala Leu Ser Arg Leu Arg His Asp Lys Glu Glu Asn Arg 
        35                  40                  45


Ala Lys Gln Asn Ala Asp Pro Ser Leu Ile Ser Trp Asp Glu Pro Gly 
    50                  55                  60


Val Asp Phe Tyr Ser Lys Pro Ala Gly Arg Arg Thr Asp Leu Lys Leu 
65                  70                  75                  80


Leu Arg Gly Leu Ser Gly Ser Asp Pro Thr Leu Asn Tyr Asn Ser Leu 
                85                  90                  95


Ser Pro Gln Glu Gly Pro Pro Asn His Ser Thr Ser Gln Gly Pro Gln 
            100                 105                 110


Pro Gly Ser Asp Pro Trp Pro Lys Gly Ser Leu Ser Gly Asp Tyr Leu 
        115                 120                 125


Tyr Ile Phe Asp Gly Ser Asp Gly Gly Val Ser Ser Ser Pro Gly Pro 
    130                 135                 140


Gly Asp Ile Glu Gly Ser Cys Lys Lys Leu Ser Pro Pro Pro Leu Pro 
145                 150                 155                 160


Pro Arg Ala Ser Ile Trp Asp Thr Pro Pro Leu Pro Pro Arg Lys Gly 
                165                 170                 175


Ser Pro Ser Ser Ser Lys Ile Ser Gln Pro Ser Asp Ile Asn Thr Phe 
            180                 185                 190


Ser Leu Val Glu Gln Leu Pro Gly Lys Leu Leu Glu His Arg Ile Leu 
        195                 200                 205


Glu Glu Glu Glu Val Leu Gly Gly Gly Gly Gln Gly Arg Leu Leu Gly 
    210                 215                 220


Ser Val Asp Tyr Asp Gly Ile Asn Asp Ala Ile Thr Arg Leu Asn Leu 
225                 230                 235                 240


Lys Ser Thr Tyr Asp Ala Glu Met Leu Arg Asp Ala Thr Arg Gly Trp 
                245                 250                 255


Lys Glu Gly Arg Gly Pro Leu Asp Phe Ser Lys Asp Thr Ser Gly Lys 
            260                 265                 270


Pro Val Ala Arg Ser Lys Thr Met Pro Pro Gln Val Pro Pro Arg Thr 
        275                 280                 285


Tyr Ala Ser Arg Tyr Gly Asn Arg Lys Asn Ala Thr Pro Gly Lys Asn 
    290                 295                 300


Arg Arg Ile Ser Ala Ala Pro Val Gly Ser Arg Pro His Thr Val Ala 
305                 310                 315                 320


Asn Gly His Glu Leu Phe Glu Val Ser Glu Glu Arg Asp Glu Glu Val 
                325                 330                 335


Ala Ala Phe Cys His Met Leu Asp Ile Leu Arg Ser Gly Ser Asp Ile 
            340                 345                 350


Gln Asp Tyr Phe Leu Thr Gly Tyr Val Trp Ser Ala Val Thr Pro Ser 
        355                 360                 365


Pro Glu His Leu Gly Asp Glu Val Asn Leu Lys Val Thr Val Leu Cys 
    370                 375                 380


Asp Arg Leu Gln Glu Ala Leu Thr Phe Thr Cys Asn Cys Ser Ser Thr 
385                 390                 395                 400


Val Asp Leu Leu Ile Tyr Gln Thr Leu Cys Tyr Thr His Asp Asp Leu 
                405                 410                 415


Arg Asn Val Asp Val Gly Asp Phe Val Leu Lys Pro Cys Gly Leu Glu 
            420                 425                 430


Glu Phe Leu Gln Asn Lys His Ala Leu Gly Ser His Glu Tyr Ile Gln 
        435                 440                 445


Tyr Cys Arg Lys Phe Asp Ile Asp Ile Arg Leu Gln Leu Met Glu Gln 
    450                 455                 460


Lys Val Val Arg Ser Asp Leu Ala Arg Thr Val Asn Asp Asp Gln Ser 
465                 470                 475                 480


Pro Ser Thr Leu Asn Tyr Leu Val His Leu Gln Glu Arg Pro Val Lys 
                485                 490                 495


Gln Thr Ile Ser Arg Gln Ala Leu Ser Leu Leu Phe Asp Thr Tyr His 
            500                 505                 510


Asn Glu Val Asp Ala Phe Leu Leu Ala Asp Gly Asp Phe Pro Leu Lys 
        515                 520                 525


Ala Asp Arg Val Val Gln Ser Val Lys Ala Ile Cys Asn Ala Leu Ala 
    530                 535                 540


Ala Val Glu Thr Pro Glu Ile Thr Ser Ala Leu Asn Gln Leu Pro Pro 
545                 550                 555                 560


Cys Pro Ser Arg Met Gln Pro Lys Ile Gln Lys Asp Pro Ser Val Leu 
                565                 570                 575


Ala Val Arg Glu Asn Arg Glu Lys Val Val Glu Ala Leu Thr Ala Ala 
            580                 585                 590


Ile Leu Asp Leu Val Glu Leu Tyr Cys Asn Thr Phe Asn Ala Asp Phe 
        595                 600                 605


Gln Thr Ala Val Pro Gly Ser Arg Lys His Asp Leu Val Gln Glu Ala 
    610                 615                 620


Cys His Phe Ala Arg Ser Leu Ala Phe Thr Val Tyr Ala Thr His Arg 
625                 630                 635                 640


Ile Pro Ile Ile Trp Ala Thr Ser Tyr Glu Asp Phe Tyr Leu Ser Cys 
                645                 650                 655


Ser Leu Ser His Gly Gly Lys Glu Leu Cys Ser Pro Leu Gln Thr Arg 
            660                 665                 670


Arg Ala His Phe Ser Lys Tyr Leu Phe His Leu Ile Val Trp Asp Gln 
        675                 680                 685


Gln Ile Cys Phe Pro Val Gln Val Asn Arg Leu Pro Arg Glu Thr Leu 
    690                 695                 700


Leu Cys Ala Thr Leu Tyr Ala Leu Pro Ile Pro Pro Pro Gly Ser Ser 
705                 710                 715                 720


Ser Glu Ala Asn Lys Gln Arg Arg Val Pro Glu Ala Leu Gly Trp Val 
                725                 730                 735


Thr Thr Pro Leu Phe Asn Phe Arg Gln Val Leu Thr Cys Gly Arg Lys 
            740                 745                 750


Leu Leu Gly Leu Trp Pro Ala Thr Gln Glu Asn Pro Ser Ala Arg Trp 
        755                 760                 765


Ser Ala Pro Asn Phe His Gln Pro Asp Ser Val Ile Leu Gln Ile Asp 
    770                 775                 780


Phe Pro Thr Ser Ala Phe Asp Ile Lys Phe Thr Ser Pro Pro Gly Asp 
785                 790                 795                 800


Lys Phe Ser Pro Arg Tyr Glu Phe Gly Ser Leu Arg Glu Glu Asp Gln 
                805                 810                 815


Arg Lys Leu Lys Asp Ile Met Gln Lys Glu Ser Leu Tyr Trp Leu Thr 
            820                 825                 830


Asp Ala Asp Lys Lys Arg Leu Trp Glu Lys Arg Tyr Tyr Cys His Ser 
        835                 840                 845


Glu Val Ser Ser Leu Pro Leu Val Leu Ala Ser Ala Pro Ser Trp Glu 
    850                 855                 860


Trp Ala Cys Leu Pro Asp Ile Tyr Val Leu Leu Lys Gln Trp Thr His 
865                 870                 875                 880


Met Asn His Gln Asp Ala Leu Gly Leu Leu His Ala Thr Phe Pro Asp 
                885                 890                 895


Gln Glu Val Arg Arg Met Ala Val Gln Trp Ile Gly Ser Leu Ser Asp 
            900                 905                 910


Ala Glu Leu Leu Asp Tyr Leu Pro Gln Leu Val Gln Ala Leu Lys Tyr 
        915                 920                 925


Glu Cys Tyr Leu Asp Ser Pro Leu Val Arg Phe Leu Leu Lys Arg Ala 
    930                 935                 940


Val Ser Asp Leu Arg Val Thr His Tyr Phe Phe Trp Leu Leu Lys Asp 
945                 950                 955                 960


Gly Leu Lys Asp Ser Gln Phe Ser Ile Arg Tyr Gln Tyr Leu Leu Ala 
                965                 970                 975


Ala Leu Leu Cys Cys Cys Gly Lys Gly Leu Arg Glu Glu Phe Asn Arg 
            980                 985                 990


Gln Cys Trp Leu Val Asn Ala Leu Ala Lys Leu Ala Gln Gln Val Arg 
        995                 1000                1005


Glu Ala Ala Pro Ser Ala Arg Gln Gly Ile Leu Arg Thr Gly Leu Glu 
    1010                1015                1020


Glu Val Lys Gln Phe Phe Ala Leu Asn Gly Ser Cys Arg Leu Pro Leu 
1025                1030                1035                1040


Ser Pro Ser Leu Leu Val Lys Gly Ile Val Pro Arg Asp Cys Ser Tyr 
                1045                1050                1055


Phe Asn Ser Asn Ala Val Pro Leu Lys Leu Ser Phe Gln Asn Val Asp 
            1060                1065                1070


Pro Leu Gly Glu Asn Ile Arg Val Ile Phe Lys Cys Gly Asp Asp Leu 
        1075                1080                1085


Arg Gln Asp Met Leu Thr Leu Gln Met Ile Arg Ile Met Ser Lys Ile 
    1090                1095                1100


Trp Val Gln Glu Gly Leu Asp Met Arg Met Val Ile Phe Arg Cys Phe 
1105                1110                1115                1120


Ser Thr Gly Arg Gly Arg Gly Met Val Glu Met Ile Pro Asn Ala Glu 
                1125                1130                1135


Thr Leu Arg Lys Ile Gln Val Glu His Gly Val Thr Gly Ser Phe Lys 
            1140                1145                1150


Asp Arg Pro Leu Ala Asp Trp Leu Gln Lys His Asn Pro Gly Glu Asp 
        1155                1160                1165


Glu Tyr Glu Lys Ala Val Glu Asn Phe Ile Tyr Ser Cys Ala Gly Cys 
    1170                1175                1180


Cys Val Ala Thr Tyr Val Leu Gly Ile Cys Asp Arg His Asn Asp Asn 
1185                1190                1195                1200


Ile Met Leu Lys Thr Thr Gly His Met Phe His Ile Asp Phe Gly Arg 
                1205                1210                1215


Phe Leu Gly His Ala Gln Met Phe Gly Asn Ile Lys Arg Asp Arg Ala 
            1220                1225                1230


Pro Phe Val Phe Thr Ser Asp Met Ala Tyr Val Ile Asn Gly Gly Asp 
        1235                1240                1245


Lys Pro Ser Ser Arg Phe His Asp Phe Val Asp Leu Cys Cys Gln Ala 
    1250                1255                1260


Tyr Asn Leu Ile Arg Lys His Thr His Leu Phe Leu Asn Leu Leu Gly 
1265                1270                1275                1280


Leu Met Leu Ser Cys Gly Ile Pro Glu Leu Ser Asp Leu Glu Asp Leu 
                1285                1290                1295


Lys Tyr Val Tyr Asp Ala Leu Arg Pro Gln Asp Thr Glu Ala Asn Ala 
            1300                1305                1310


Thr Thr Tyr Phe Thr Arg Leu Ile Glu Ser Ser Leu Gly Ser Val Ala 
        1315                1320                1325


Thr Lys Leu Asn Phe Phe Ile His Asn Leu Ala Gln Met Lys Phe Thr 
    1330                1335                1340


Gly Ser Asp Asp Arg Leu Thr Leu Ser Phe Ala Ser Arg Thr His Thr 
1345                1350                1355                1360


Leu Lys Ser Ser Gly Arg Ile Ser Asp Val Phe Leu Cys Arg His Glu 
                1365                1370                1375


Lys Ile Phe His Pro Asn Lys Gly Tyr Ile Tyr Val Val Lys Val Met 
            1380                1385                1390


Arg Glu Asn Thr His Glu Ala Thr Tyr Ile Gln Arg Thr Phe Glu Glu 
        1395                1400                1405


Phe Gln Glu Leu His Asn Lys Leu Arg Leu Leu Phe Pro Ser Ser His 
    1410                1415                1420


Leu Pro Ser Phe Pro Ser Arg Phe Val Ile Gly Arg Ser Arg Gly Glu 
1425                1430                1435                1440


Ala Val Ala Glu Arg Arg Arg Glu Glu Leu Asn Gly Tyr Ile Trp His 
                1445                1450                1455


Leu Ile His Ala Pro Pro Glu Val Ala Glu Cys Asp Leu Val Tyr Thr 
            1460                1465                1470


Phe Phe His Pro Leu Pro Arg Asp Glu Lys Ala Met Gly Thr Ser Pro 
        1475                1480                1485


Ala Pro Lys Ser Ser Asp Gly Thr Trp Ala Arg Pro Val Gly Lys Val 
    1490                1495                1500


Gly Gly Glu Val Lys Leu Ser Ile Ser Tyr Lys Asn Asn Lys Leu Phe 
1505                1510                1515                1520


Ile Met Val Met His Ile Arg Gly Leu Gln Leu Leu Gln Asp Gly Asn 
                1525                1530                1535


Asp Pro Asp Pro Tyr Val Lys Ile Tyr Leu Leu Pro Asp Pro Gln Lys 
            1540                1545                1550


Thr Thr Lys Arg Lys Thr Lys Val Ala Arg Lys Thr Cys Asn Pro Thr 
        1555                1560                1565


Tyr Asn Glu Met Leu Val Tyr Asp Gly Ile Pro Lys Gly Asp Leu Gln 
    1570                1575                1580


Gln Arg Glu Leu Gln Leu Ser Val Leu Ser Glu Gln Gly Phe Trp Glu 
1585                1590                1595                1600


Asn Val Leu Leu Gly Glu Val Asn Ile Arg Leu Arg Glu Leu Asp Leu 
                1605                1610                1615


Ala Gln Glu Lys Thr Gly Trp Phe Ala Leu Gly Ser Arg Ser His Gly 
            1620                1625                1630


Thr Leu 



<210>  1976
<211>  2735
<212>  DNA
<213>  Homo sapiens

<400>  1976
ggctcgcggc ggattcggcg ctgcggctgg agccggcggc cgggtgcctg cctgtccagg     60

cagggtctgg ccgagcgtcg cgtcgccgtg cagtgcgccg ggtgtccggg agatggcttc    120

ccctctctcg cccgctgctg ccgctattgt ctcacccggg gtggcctgac tctgcgagct    180

cgcgcacgct ctcggcggag agcacccctc cccaccccca caagctggtc cttgcgccct    240

ttgctgcctc tccctctgcc ccttggagcc tagggtctgt gcggagcctg gagaggggag    300

cggcccggga gcaggcggcg tgcggccggc cagctcctct cgcgctggtg caagaggcgc    360

ctggagccgc agagcgagcc cgggaggcgc ggagcgagca gcccacgtcg ccaggcacaa    420

gacacgtcgg atgttgcagc agagccagca gctagcgcag gcgcccagac accatgtcac    480

aaccctccag aactgacgtt ggcaggaagt agagactttg ttgcctgtgt cccccatcct    540

caccatgtct tcgactcagg gcaatgggga acactggaag tccctggagt cagtgggcat    600

cagccgcaaa gagctagcga tggccgaagc cctgcagatg gagtatgatg ccctgtcccg    660

gctccggcat gacaaggagg agaacagagc caagcagaac gcagacccct ctctcatcag    720

ctgggatgag cctggggtag acttttacag caagccagca ggaaggcgga ccgacctcaa    780

gctgttacgc ggtctctctg gctctgatcc tacccttaac tacaactcac tctccccaca    840

ggaagggccg cccaaccact ctacctccca agggccacag cctggctcag atccctggcc    900

caaaggctcc ctgtctggag actatctcta catttttgat ggttcagatg ggggagtctc    960

ttcgtcccca ggaccagggg acatagaggg ctcttgcaag aaactatccc cacctcctct   1020

gcctccccga gcttctatct gggatacccc tcccctgcct cccagaaagg ggtccccctc   1080

atcctccaag atctcccagc ccagtgacat caacactttc tctttggtcg aacaattgcc   1140

gggcaaactg ctagagcatc ggatcctaga agaggaagag gtgctgggag gtgggggtca   1200

ggggcgccta ctggggtctg tggactatga tggtatcaat gatgcaatta ctaggctcaa   1260

cttgaaatcg acctatgatg cggagatgtt gcgggatgcc accaggggct ggaaggaggg   1320

ccgagggccg ctggacttca gcaaagacac ctctggaaaa cccgtggcca ggagcaagac   1380

tatgccccct caggtgcccc cccgcaccta tgcctcccgc tatggcaacc gaaagaatgc   1440

gacgcctggc aagaaccgcc ggatttctgc agccccggtg ggctcccggc cccacactgt   1500

tgccaatggc catgagttgt ttgaggtctc agaagagaga gatgaggagg ttgctgcatt   1560

ttgccacatg ctggatatcc ttcgatctgg ctctgacatc caagactact tcctcactgg   1620

ctatgtctgg agtgctgtca cccctagccc agagcacctc ggggatgagg tcaacctgaa   1680

ggtgactgtg ttgtgtgaca ggcttcaaga ggcactcact ttcacctgca actgttcctc   1740

cactgtagac ttgcttatct accagaccct gtgctacacc catgatgacc tgaggaatgt   1800

ggacgtgggt gactttgtgc taaagccctg cgggctggag gagttcctgc agaacaagca   1860

tgccttgggc agtcatgagt acatccaata ctgccgcaag tttgacattg acattcggct   1920

acagctgatg gagcagaagg ttgtgcgcag tgacctggcc cggacggtga atgatgacca   1980

gagcccctcc accttgaact acctcgtcca tctccaagag aggcctgtca agcagaccat   2040

cagcaggcag gccctgagtc ttctgttcga cacttaccac aatgaggtgg atgccttcct   2100

gctggctgat ggagacttcc cactgaaggc tgacagggtg gtccagtccg tcaaggccat   2160

ctgcaacgcc ctggccgccg tggaaacccc tgagatcacc agtgctctca accagctgcc   2220

cccctgcccc tcccgcatgc agcctaaaat tcagaaggat cccagtgtct tggctgtgag   2280

ggaaaaccga gagaaggtcg tggaagccct gaccgctgcc atcttggacc tggtggagct   2340

gtactgcaac acattcaacg cagacttcca gacggcagtg cccgggagcc gcaagcatga   2400

cctggtccag gaggcctgcc atttcgccag gtccctggcc ttcactgtct atgccaccca   2460

ccgcatcccc atcatctggg ctaccagcta tgaagatttc tacctctcct gctccctcag   2520

ccatggcggc aaggagctgt gcagccccct gcagacccga agagctcact tctccaagta   2580

cctcttccac ctcatcgtct gggaccagca gtaagccctt cccccaggct tcagtgccca   2640

ggccactgta gacctgctca gcctctgaaa tatccctggg gccagataac tagtccagga   2700

ctaatgataa aaccaggctc cttgttaacc ctaac                              2735


<210>  1977
<211>  689
<212>  PRT
<213>  Homo sapiens

<400>  1977

Met Ser Ser Thr Gln Gly Asn Gly Glu His Trp Lys Ser Leu Glu Ser 
1               5                   10                  15


Val Gly Ile Ser Arg Lys Glu Leu Ala Met Ala Glu Ala Leu Gln Met 
            20                  25                  30


Glu Tyr Asp Ala Leu Ser Arg Leu Arg His Asp Lys Glu Glu Asn Arg 
        35                  40                  45


Ala Lys Gln Asn Ala Asp Pro Ser Leu Ile Ser Trp Asp Glu Pro Gly 
    50                  55                  60


Val Asp Phe Tyr Ser Lys Pro Ala Gly Arg Arg Thr Asp Leu Lys Leu 
65                  70                  75                  80


Leu Arg Gly Leu Ser Gly Ser Asp Pro Thr Leu Asn Tyr Asn Ser Leu 
                85                  90                  95


Ser Pro Gln Glu Gly Pro Pro Asn His Ser Thr Ser Gln Gly Pro Gln 
            100                 105                 110


Pro Gly Ser Asp Pro Trp Pro Lys Gly Ser Leu Ser Gly Asp Tyr Leu 
        115                 120                 125


Tyr Ile Phe Asp Gly Ser Asp Gly Gly Val Ser Ser Ser Pro Gly Pro 
    130                 135                 140


Gly Asp Ile Glu Gly Ser Cys Lys Lys Leu Ser Pro Pro Pro Leu Pro 
145                 150                 155                 160


Pro Arg Ala Ser Ile Trp Asp Thr Pro Pro Leu Pro Pro Arg Lys Gly 
                165                 170                 175


Ser Pro Ser Ser Ser Lys Ile Ser Gln Pro Ser Asp Ile Asn Thr Phe 
            180                 185                 190


Ser Leu Val Glu Gln Leu Pro Gly Lys Leu Leu Glu His Arg Ile Leu 
        195                 200                 205


Glu Glu Glu Glu Val Leu Gly Gly Gly Gly Gln Gly Arg Leu Leu Gly 
    210                 215                 220


Ser Val Asp Tyr Asp Gly Ile Asn Asp Ala Ile Thr Arg Leu Asn Leu 
225                 230                 235                 240


Lys Ser Thr Tyr Asp Ala Glu Met Leu Arg Asp Ala Thr Arg Gly Trp 
                245                 250                 255


Lys Glu Gly Arg Gly Pro Leu Asp Phe Ser Lys Asp Thr Ser Gly Lys 
            260                 265                 270


Pro Val Ala Arg Ser Lys Thr Met Pro Pro Gln Val Pro Pro Arg Thr 
        275                 280                 285


Tyr Ala Ser Arg Tyr Gly Asn Arg Lys Asn Ala Thr Pro Gly Lys Asn 
    290                 295                 300


Arg Arg Ile Ser Ala Ala Pro Val Gly Ser Arg Pro His Thr Val Ala 
305                 310                 315                 320


Asn Gly His Glu Leu Phe Glu Val Ser Glu Glu Arg Asp Glu Glu Val 
                325                 330                 335


Ala Ala Phe Cys His Met Leu Asp Ile Leu Arg Ser Gly Ser Asp Ile 
            340                 345                 350


Gln Asp Tyr Phe Leu Thr Gly Tyr Val Trp Ser Ala Val Thr Pro Ser 
        355                 360                 365


Pro Glu His Leu Gly Asp Glu Val Asn Leu Lys Val Thr Val Leu Cys 
    370                 375                 380


Asp Arg Leu Gln Glu Ala Leu Thr Phe Thr Cys Asn Cys Ser Ser Thr 
385                 390                 395                 400


Val Asp Leu Leu Ile Tyr Gln Thr Leu Cys Tyr Thr His Asp Asp Leu 
                405                 410                 415


Arg Asn Val Asp Val Gly Asp Phe Val Leu Lys Pro Cys Gly Leu Glu 
            420                 425                 430


Glu Phe Leu Gln Asn Lys His Ala Leu Gly Ser His Glu Tyr Ile Gln 
        435                 440                 445


Tyr Cys Arg Lys Phe Asp Ile Asp Ile Arg Leu Gln Leu Met Glu Gln 
    450                 455                 460


Lys Val Val Arg Ser Asp Leu Ala Arg Thr Val Asn Asp Asp Gln Ser 
465                 470                 475                 480


Pro Ser Thr Leu Asn Tyr Leu Val His Leu Gln Glu Arg Pro Val Lys 
                485                 490                 495


Gln Thr Ile Ser Arg Gln Ala Leu Ser Leu Leu Phe Asp Thr Tyr His 
            500                 505                 510


Asn Glu Val Asp Ala Phe Leu Leu Ala Asp Gly Asp Phe Pro Leu Lys 
        515                 520                 525


Ala Asp Arg Val Val Gln Ser Val Lys Ala Ile Cys Asn Ala Leu Ala 
    530                 535                 540


Ala Val Glu Thr Pro Glu Ile Thr Ser Ala Leu Asn Gln Leu Pro Pro 
545                 550                 555                 560


Cys Pro Ser Arg Met Gln Pro Lys Ile Gln Lys Asp Pro Ser Val Leu 
                565                 570                 575


Ala Val Arg Glu Asn Arg Glu Lys Val Val Glu Ala Leu Thr Ala Ala 
            580                 585                 590


Ile Leu Asp Leu Val Glu Leu Tyr Cys Asn Thr Phe Asn Ala Asp Phe 
        595                 600                 605


Gln Thr Ala Val Pro Gly Ser Arg Lys His Asp Leu Val Gln Glu Ala 
    610                 615                 620


Cys His Phe Ala Arg Ser Leu Ala Phe Thr Val Tyr Ala Thr His Arg 
625                 630                 635                 640


Ile Pro Ile Ile Trp Ala Thr Ser Tyr Glu Asp Phe Tyr Leu Ser Cys 
                645                 650                 655


Ser Leu Ser His Gly Gly Lys Glu Leu Cys Ser Pro Leu Gln Thr Arg 
            660                 665                 670


Arg Ala His Phe Ser Lys Tyr Leu Phe His Leu Ile Val Trp Asp Gln 
        675                 680                 685


Gln 



<210>  1978
<211>  1014
<212>  DNA
<213>  Homo sapiens

<400>  1978
tgcccctggc tgctgatgcc ttctgtgaca gcttagcatt ctacttcatt ctgtcctggt     60

ttcctcctta gccattgttt aaggggcact ggggttttcc caccttgtgt ctagcctttg    120

ggaaccttcc caactctgaa gagctacaca gttcttcctt cctccgcttc tcctaagaga    180

gtccccccaa aagcagaatc agctcctggg ataagccaca tccctagagc tcagggattt    240

ttaaaggccc tgctctgaga ggtggggctg ttcccgctat ttatagggac tgggagattc    300

ctgttcccag ctctgagttc ctcacaccca gctgggcctg ctcactgagt cagggcaccc    360

tggtaggtgg tcacctctgt cactccttct ctctcctgcc tcccctactc cctcaccctt    420

ccccatcccc tgcatgtcat cagagttctg agacagagct cagcccagaa tctccttgaa    480

gaagcggaca caaagcaaaa agctcttgcc agttctgagt ggggaaatgc ggccttggtc    540

ctccccggct cagcttgttg caggggctca gcctgctggg aggggggacc ccttgggccc    600

tcggcctata ccaccgcccc gctttcgtcg ggcttccagc cagagggaac ctccttatcc    660

caggccagcg gagccagctc tggaactggc tggctccaaa tgccagcctg atacccctgc    720

tgccagcctc tgcccggcag actcccccag ccagcatcgg gtgatgccac cagggcctgc    780

cagctgggca aacgtgggct cccggcccca cactgttgcc aatggccatg agttgtttga    840

ggtctcagaa gagagagatg aggaggttgc tgcattttgc cacatgctgg atatccttcg    900

atctggctct gacatccaag actacttcct cactggctat gtctggagtg ctgtcacccc    960

tagcccagag cacctcgggg atgaggtcaa cctgaaggtg actgtgttgt gtga         1014


<210>  1979
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  1979

Met Arg Pro Trp Ser Ser Pro Ala Gln Leu Val Ala Gly Ala Gln Pro 
1               5                   10                  15


Ala Gly Arg Gly Asp Pro Leu Gly Pro Arg Pro Ile Pro Pro Pro Arg 
            20                  25                  30


Phe Arg Arg Ala Ser Ser Gln Arg Glu Pro Pro Tyr Pro Arg Pro Ala 
        35                  40                  45


Glu Pro Ala Leu Glu Leu Ala Gly Ser Lys Cys Gln Pro Asp Thr Pro 
    50                  55                  60


Ala Ala Ser Leu Cys Pro Ala Asp Ser Pro Ser Gln His Arg Val Met 
65                  70                  75                  80


Pro Pro Gly Pro Ala Ser Trp Ala Asn Val Gly Ser Arg Pro His Thr 
                85                  90                  95


Val Ala Asn Gly His Glu Leu Phe Glu Val Ser Glu Glu Arg Asp Glu 
            100                 105                 110


Glu Val Ala Ala Phe Cys His Met Leu Asp Ile Leu Arg Ser Gly Ser 
        115                 120                 125


Asp Ile Gln Asp Tyr Phe Leu Thr Gly Tyr Val Trp Ser Ala Val Thr 
    130                 135                 140


Pro Ser Pro Glu His Leu Gly Asp Glu Val Asn Leu Lys Val Thr Val 
145                 150                 155                 160


Leu 



<210>  1980
<211>  595
<212>  DNA
<213>  Homo sapiens

<400>  1980
acactcccaa catgtaggtg gcctcatcag aaggtaaaaa ctgaagaaaa aaatcattca     60

aactcccata tactagatct ttctcattta atcttgaggt ttccatgttg agaggagtga    120

aaggagattt ctgtacccat tagccaagat tgtctgaaac aaatcccagg aagatgtttt    180

gaaagaagaa tacataagcc ttatgactca gttctcagta gcttcttcag tatctttctt    240

ttaaaatatc attttaaagt cttgcattat agcactaaaa aagctaaaag aatgctaaaa    300

ttgcactaaa tccaaccacg ccagcaagcc tgctcaattc atttcttcag acatcactcc    360

gaaattgcca gagtggtttc ccactgacag acttcatcgc tgtactgcac atctcttcac    420

tacaaatggg gagatgagac agagacaaaa agagaaatgg atttactgtg ctggggaagt    480

taagcacaca ctgggttgga atttcatttc cactgaatta gaagctctgg ctcagcacgg    540

atgacacagt gatgctcctt taataacaca aaataaataa aacatggaaa aggtt         595


<210>  1981
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  1981

Met Arg Gln Arg Gln Lys Glu Lys Trp Ile Tyr Cys Ala Gly Glu Val 
1               5                   10                  15


Lys His Thr Leu Gly Trp Asn Phe Ile Ser Thr Glu Leu Glu Ala Leu 
            20                  25                  30


Ala Gln His Gly 
        35


<210>  1982
<211>  385
<212>  DNA
<213>  Homo sapiens

<400>  1982
gctggagcac actgaagctg gagcacactg aagtggaaga tggggctgca gacagagact     60

gggcagcctc tgctccaggg aggcccgaga gccagagagc agattccata agaagaataa    120

ctcccattcc tcatgcatga gaccctctgc taaatgcttc ctgtgcacca cctccagaaa    180

tcctcccaag ccaggacacc agcagtatta caggaactgg atgacaaaaa gaagagccga    240

tataaccagg aacctactct ggccacccca agtaaggatc taaagtccag cctcctcctc    300

cactgccctc aaggcctttc ctcatgaaag cagaggttct gaatgctgat ttctgtttta    360

aagcccaata actctttaaa catct                                          385


<210>  1983
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  1983

Met Leu Pro Val His His Leu Gln Lys Ser Ser Gln Ala Arg Thr Pro 
1               5                   10                  15


Ala Val Leu Gln Glu Leu Asp Asp Lys Lys Lys Ser Arg Tyr Asn Gln 
            20                  25                  30


Glu Pro Thr Leu Ala Thr Pro Ser Lys Asp Leu Lys Ser Ser Leu Leu 
        35                  40                  45


Leu His Cys Pro Gln Gly Leu Ser Ser 
    50                  55


<210>  1984
<211>  666
<212>  DNA
<213>  Homo sapiens

<400>  1984
agacaggaag catgagggca ggctcatcag tgtcagagca ggggagacca gcacagacac     60

cttacaagca gaatgacctt ctgtggctac agagaaaggc ttcaggcaaa gagatgcagc    120

tctgggcccc agagtccgct ggagcacact gaagctggag cacactgaag tggaagatgg    180

ggctgcagac agagactggg cagcctctgc tccagggagg cccgagagcc agagagcaga    240

ttccataaga agaataactc ccattcctca tgcatgagac cctctgctaa atgcttcctg    300

tgcaccacct ccagaaatcc tcccaagcca ggacaccagc agtattacag gtaagaaaat    360

ggaggctccc agagatttga caacctgccc gcagcaatga ccaaatcaga cttggtgcta    420

agtctgcacc tccccaaagt cagtgtgttt gtatgctctg ctgccactgc cccccgctgg    480

ccctgcacat gatgtgaacc atcaggcaga cctggagttc tgtctcctgg gtgggctgct    540

tgccaacacc agggtggctg gcccctgcct gtgtcaggtc ctgcagtgtt gactctcttc    600

gtgtgatgtt gggcaggtgg agctggttgt gctgagcctg aggaaacatc caatgtgcca    660

aacttt                                                               666


<210>  1985
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  1985

Met Arg Ala Gly Ser Ser Val Ser Glu Gln Gly Arg Pro Ala Gln Thr 
1               5                   10                  15


Pro Tyr Lys Gln Asn Asp Leu Leu Trp Leu Gln Arg Lys Ala Ser Gly 
            20                  25                  30


Lys Glu Met Gln Leu Trp Ala Pro Glu Ser Ala Gly Ala His 
        35                  40                  45


<210>  1986
<211>  338
<212>  DNA
<213>  Homo sapiens

<400>  1986
gagctgcctt ggtgctgtaa aggtaagaaa atggaggctc ccagagattt gacaacctgc     60

ccgcagcaat gaccaaatca gacttggtgc taagtctgca cctccccaaa gtcagtgtgt    120

ttgtatgctc tgctgccact gccccccgct ggccctgcac atgatgtgaa ccatcaggca    180

gacctggagt tctgtctcct gggtgggctg cttgccaaca ccagggtggc tggcccctgc    240

ctgtgtcagg tcctgcagtg ttgactctct tcgtgtgatg ttgggcaggt ggagctggtt    300

gtgctgagcc tgaggaaaca tccaatgtgc caaacttt                            338


<210>  1987
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  1987

Met Thr Lys Ser Asp Leu Val Leu Ser Leu His Leu Pro Lys Val Ser 
1               5                   10                  15


Val Phe Val Cys Ser Ala Ala Thr Ala Pro Arg Trp Pro Cys Thr 
            20                  25                  30


<210>  1988
<211>  475
<212>  DNA
<213>  Homo sapiens

<400>  1988
cctttttctc attgttatgg taggagtgac attctcttgt ggctttctac aaactgaata     60

gaaatagatc tcctagggaa ggtggaaggc ttttcattca aaaaatctat ttctttagta    120

gatacaggaa cattaaaatt gtcttcttca tctttgggga ctgtggctgt cagtggagta    180

acgagaaaga ggaacaaaga tgggaaaaga ccagcagcta tttgtgaggc tgtggccatt    240

cctgcctcca cccccagacc acctgctgaa gggagagatg ttaaaaagaa ccacgttttc    300

cattcctcaa agccaaacaa acacagagag tcggctgagc ctctctaaat cagtgactgc    360

caggggagta aaatgctgaa cccaccaaaa ggccacatct gcgaaataaa tccatgtcct    420

gagagtcaaa tcaaaacaga tgtggtccca cagcagggac ccctcccatg gagag         475


<210>  1989
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  1989

Met Gly Lys Asp Gln Gln Leu Phe Val Arg Leu Trp Pro Phe Leu Pro 
1               5                   10                  15


Pro Pro Pro Asp His Leu Leu Lys Gly Glu Met Leu Lys Arg Thr Thr 
            20                  25                  30


Phe Ser Ile Pro Gln Ser Gln Thr Asn Thr Glu Ser Arg Leu Ser Leu 
        35                  40                  45


Ser Lys Ser Val Thr Ala Arg Gly Val Lys Cys 
    50                  55


<210>  1990
<211>  1418
<212>  DNA
<213>  Homo sapiens

<400>  1990
ggagctgggg ccgggcttcg gcgcagaggc aggaagagga agcggcaccc gcttcgggga     60

cccagccggc ggccaggcca ccgcgcccac ccggccgatg gcaccgtgtt cctgcgcctc    120

gggagggagg aggctctgcg cgggactgca ggttctgccc cgcatcggag tgatcgctga    180

gcctgacgct ctcgaaggct gggcctgggg cccgcaatct actccggagg ctttcccact    240

gggcagggtc gctagcaggg tgccacccgg gtgcagtgag gacctggagc ccctgcccca    300

ggctgtgagg agacttgacc agagctgcct gaatgctcca cggagcagga ggaagcattc    360

ccatgtgaaa gatgagctcc ctataaaagc aacgctctta tcatcgagaa cagaaagttg    420

aagccaagag agagctccac aagctgacct tgttaaacta acccttatct tcttagtcgc    480

ttctttaccc aattaactac cctagccgaa gcccctttgc cttattacat tttgcaacag    540

tgttcgttgt ccaattcagt atacaagtga gtgactctgg atgctttttg gggtcttcgt    600

ttccttatga gggcttctgt gccatgtaaa acttgtatta aataaatttg tatgcttttc    660

tcctgttaat ctgtctatat cgattgaact ttagggtcca gtcagaaccc aaagaggatg    720

gaggtggagt tttggctcct ctacagctat ctgaataatc aaaattcaag atattccatg    780

ttctttctga gtttctttga aattaaaaat gcagacaacc actcaactaa tacgtcagcg    840

agatacgttt tctgtcctta ttgccttact gatgaaattg cctttattca taaaaaataa    900

atgtgggagt cttgtttatt tatttctaat gacattaact tgacattaac cttggtgctc    960

ttgggaacca taaatgggcc ctgtactact tgttacagag tataaattcc cagaactaca   1020

agtacatcat attcctcaag ttactgaaga atttcatgat ccatgtgtca ggcctctgag   1080

cccaagctaa gtcatcatat cccctgtgac ctgcacgtat acatccagat ggccggttcc   1140

tgccttaact gatgacattc caccacaaaa gaagtgaaaa tggcctgttc ctgccttaac   1200

tgatgacatt gtcttgtgaa attccttctc ctggctcatc ctggctcaaa agctccccca   1260

ctgaatacct tgtgaccccc aactcctgcc cgccagagag ccacccccct ttttccttta   1320

cctacccaag tcctataaaa cagcgccacc cctatctccc tttgctgact ctcttttcgg   1380

actcagccca cttgcaccca ggtgattaaa agctttat                           1418


<210>  1991
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  1991

Met Ala Pro Cys Ser Cys Ala Ser Gly Gly Arg Arg Leu Cys Ala Gly 
1               5                   10                  15


Leu Gln Val Leu Pro Arg Ile Gly Val Ile Ala Glu Pro Asp Ala Leu 
            20                  25                  30


Glu Gly Trp Ala Trp Gly Pro Gln Ser Thr Pro Glu Ala Phe Pro Leu 
        35                  40                  45


Gly Arg Val Ala Ser Arg Val Pro Pro Gly Cys Ser Glu Asp Leu Glu 
    50                  55                  60


Pro Leu Pro Gln Ala Val Arg Arg Leu Asp Gln Ser Cys Leu Asn Ala 
65                  70                  75                  80


Pro Arg Ser Arg Arg Lys His Ser His Val Lys Asp Glu Leu Pro Ile 
                85                  90                  95


Lys Ala Thr Leu Leu Ser Ser Arg Thr Glu Ser 
            100                 105


<210>  1992
<211>  944
<212>  DNA
<213>  Homo sapiens

<400>  1992
gttcctgcgc ctcgggaggg aggaggctct gcgcgggact gcaggttctg ccccgcatcg     60

gagtgatcgc tgagcctgac gctctcgaag gctgggcctg gggcccgcaa tctactccgg    120

aggctttccc actgggcagg gtcgctagca gggaggaagc attcccatgt gaaagatgag    180

ctccctataa aagcaacgct cttatcatcg agaacagaaa gttgaagcca agagagagct    240

ccacaagctg accttgttaa actaaccctt atcttcttag tcgcttcttt acccaattaa    300

ctaccctagc cgaagcccct ttgccttatt acattttgca acagtgttcg ttgtccaatt    360

cagtatacaa gtgagtgact ctggatgctt tttggggtct tcgtttcctt atgagggctt    420

ctgtgccatg taaaacttgt attaaataaa tttgtatgct tttctcctgt taatctgtct    480

atatcgattg aactttaggg tccagtcaga acccaaagag gatggaggtg gagttttggc    540

tcctctacag ctatctgaat aatcaaaatt caagatattc catgttcttt ctgagtttct    600

ttgaaattaa aaatgcagac aaccactcaa ctaatacgtc agcgagatac gttttctgtc    660

cttattgcct tactgatgaa attgccttta ttcataaaaa ataaatgtgg gagtcttgtt    720

tatttatttc taatgacatt aacttgacat taaccttggt gctcttggga accataaatg    780

ggccctgtac tacttgttac agagtataaa ttcccagaac tacaagtaca tcatattcct    840

caagttactg aagaatttca tgatccatgt gtcaggcctc tgagcccaag ctaagtcatc    900

atatcccctg tgacctgcac gtatacatcc agatggccgg ttcc                     944


<210>  1993
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  1993

Met Glu Val Glu Phe Trp Leu Leu Tyr Ser Tyr Leu Asn Asn Gln Asn 
1               5                   10                  15


Ser Arg Tyr Ser Met Phe Phe Leu Ser Phe Phe Glu Ile Lys Asn Ala 
            20                  25                  30


Asp Asn His Ser Thr Asn Thr Ser Ala Arg Tyr Val Phe Cys Pro Tyr 
        35                  40                  45


Cys Leu Thr Asp Glu Ile Ala Phe Ile His Lys Lys 
    50                  55                  60


<210>  1994
<211>  1866
<212>  DNA
<213>  Homo sapiens

<400>  1994
gacaaccggc gtggaggcgt ggccacagcc gcccagaaat tctacccaag ctccctcagc     60

accatgtacc gagcacttcg gctcctcgcg cgctcgcgtc ccctcgtgcg ggctccagcc    120

gcagccttag cttcggctcc cggcttgggt ggcgcggccg tgccctcgtt ttggcctccg    180

aacgcggctc gaatggcaag ccaaaattcc ttccggatag aatatgatac ctttggtgaa    240

ctaaaggtgc caaatgataa gtattatggc gcccagaccg tgagatctac gatgaacttt    300

aagattggag gtgtgacaga acgcatgcca accccagtta ttaaagcttt tggcatcttg    360

aagcgagcgg ccgctgaagt aaaccaggat tatggtcttg atccaaagat tgctaatgca    420

ataatgaagg cagcagatga ggtagctgaa ggtaaattaa atgatcattt tcctctcgtg    480

gtatggcaga ctggatcagg aactcagaca aatatgaatg taaatgaagt cattagcaat    540

agagcaattg aaatgttagg aggtgaactt ggcagcaaga tacctgtgca tcccaacgat    600

catgttaata aaagccagag ctcaaatgat acttttccca cagcaatgca cattgctgct    660

gcaatagaag ttcatgaagt actgttacca ggactacaga agttacatga tgctcttgat    720

gcaaaatcca aagagtttgc acagatcatc aagattggac gtactcatac tcaggatgct    780

gttccactta ctcttgggca ggaatttagt ggttatgttc aacaagtaaa atatgcaatg    840

acaagaataa aagctgccat gccaagaatc tatgagctcg cagctggagg cactgctgtt    900

ggtacaggtt taaatactag aattggcttt gcagaaaagg ttgctgcaaa agtggctgca    960

cttacaggct tgccttttgt cactgctccg aataaatttg aagctctggc tgctcatgac   1020

gctctggttg agctcagtgg agccatgaac actactgcct gcagtctgat gaagatagca   1080

aatgatattc gatttttggg ttctggtcct cggtcaggtc tgggagaatt gatcttgcct   1140

gaaaatgaac caggaagcag tatcatgcca ggcaaggtga accctactca gtgtgaagca   1200

atgaccatgg ttgcagccca agtcatgggg aaccatgttg ctgtcactgt cggaggcagc   1260

aatggacatt ttgagttgaa tgttttcaag ccaatgatga ttaaaaatgt gttacactca   1320

gccaggctgc tgggggatgc ttcagtttcc tttacagaaa actgcgtggt gggaatccag   1380

gccaatacag aaaggatcaa caagctgatg aatgagtctc taatgttggt gacagctctc   1440

aatcctcata tagggtatga caaggcagca aagattgcta agacagcaca caaaaatgga   1500

tcaaccttaa aggaaactgc tatcgaactt ggctatctca cagcagagca gtttgacgaa   1560

tgggtaaaac ctaaggacat gctgggtcca aagtgattta cataaattta taatgaaaat   1620

aaacatgtat aaaatttaaa aaaacagact cccatttctt aaaaacggat aagtttgaaa   1680

ggaaactgct attgaactta agcatctcta gcagagcaat ttgatcagta tataaaaccc   1740

taggatgtgc taggtctaag atggattaaa caagtataaa ataaaataca tttataaaat   1800

aaaaaggaaa acagacttaa attttctcct atgttaattg acttgtatta tagttgaatc   1860

tatgat                                                              1866


<210>  1995
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  1995

Met Tyr Arg Ala Leu Arg Leu Leu Ala Arg Ser Arg Pro Leu Val Arg 
1               5                   10                  15


Ala Pro Ala Ala Ala Leu Ala Ser Ala Pro Gly Leu Gly Gly Ala Ala 
            20                  25                  30


Val Pro Ser Phe Trp Pro Pro Asn Ala Ala Arg Met Ala Ser Gln Asn 
        35                  40                  45


Ser Phe Arg Ile Glu Tyr Asp Thr Phe Gly Glu Leu Lys Val Pro Asn 
    50                  55                  60


Asp Lys Tyr Tyr Gly Ala Gln Thr Val Arg Ser Thr Met Asn Phe Lys 
65                  70                  75                  80


Ile Gly Gly Val Thr Glu Arg Met Pro Thr Pro Val Ile Lys Ala Phe 
                85                  90                  95


Gly Ile Leu Lys Arg Ala Ala Ala Glu Val Asn Gln Asp Tyr Gly Leu 
            100                 105                 110


Asp Pro Lys Ile Ala Asn Ala Ile Met Lys Ala Ala Asp Glu Val Ala 
        115                 120                 125


Glu Gly Lys Leu Asn Asp His Phe Pro Leu Val Val Trp Gln Thr Gly 
    130                 135                 140


Ser Gly Thr Gln Thr Asn Met Asn Val Asn Glu Val Ile Ser Asn Arg 
145                 150                 155                 160


Ala Ile Glu Met Leu Gly Gly Glu Leu Gly Ser Lys Ile Pro Val His 
                165                 170                 175


Pro Asn Asp His Val Asn Lys Ser Gln Ser Ser Asn Asp Thr Phe Pro 
            180                 185                 190


Thr Ala Met His Ile Ala Ala Ala Ile Glu Val His Glu Val Leu Leu 
        195                 200                 205


Pro Gly Leu Gln Lys Leu His Asp Ala Leu Asp Ala Lys Ser Lys Glu 
    210                 215                 220


Phe Ala Gln Ile Ile Lys Ile Gly Arg Thr His Thr Gln Asp Ala Val 
225                 230                 235                 240


Pro Leu Thr Leu Gly Gln Glu Phe Ser Gly Tyr Val Gln Gln Val Lys 
                245                 250                 255


Tyr Ala Met Thr Arg Ile Lys Ala Ala Met Pro Arg Ile Tyr Glu Leu 
            260                 265                 270


Ala Ala Gly Gly Thr Ala Val Gly Thr Gly Leu Asn Thr Arg Ile Gly 
        275                 280                 285


Phe Ala Glu Lys Val Ala Ala Lys Val Ala Ala Leu Thr Gly Leu Pro 
    290                 295                 300


Phe Val Thr Ala Pro Asn Lys Phe Glu Ala Leu Ala Ala His Asp Ala 
305                 310                 315                 320


Leu Val Glu Leu Ser Gly Ala Met Asn Thr Thr Ala Cys Ser Leu Met 
                325                 330                 335


Lys Ile Ala Asn Asp Ile Arg Phe Leu Gly Ser Gly Pro Arg Ser Gly 
            340                 345                 350


Leu Gly Glu Leu Ile Leu Pro Glu Asn Glu Pro Gly Ser Ser Ile Met 
        355                 360                 365


Pro Gly Lys Val Asn Pro Thr Gln Cys Glu Ala Met Thr Met Val Ala 
    370                 375                 380


Ala Gln Val Met Gly Asn His Val Ala Val Thr Val Gly Gly Ser Asn 
385                 390                 395                 400


Gly His Phe Glu Leu Asn Val Phe Lys Pro Met Met Ile Lys Asn Val 
                405                 410                 415


Leu His Ser Ala Arg Leu Leu Gly Asp Ala Ser Val Ser Phe Thr Glu 
            420                 425                 430


Asn Cys Val Val Gly Ile Gln Ala Asn Thr Glu Arg Ile Asn Lys Leu 
        435                 440                 445


Met Asn Glu Ser Leu Met Leu Val Thr Ala Leu Asn Pro His Ile Gly 
    450                 455                 460


Tyr Asp Lys Ala Ala Lys Ile Ala Lys Thr Ala His Lys Asn Gly Ser 
465                 470                 475                 480


Thr Leu Lys Glu Thr Ala Ile Glu Leu Gly Tyr Leu Thr Ala Glu Gln 
                485                 490                 495


Phe Asp Glu Trp Val Lys Pro Lys Asp Met Leu Gly Pro Lys 
            500                 505                 510


<210>  1996
<211>  1818
<212>  DNA
<213>  Homo sapiens

<400>  1996
gacaaccggc gtggaggcgt ggccacagcc gcccagaaat tctacccaag ctccctcagc     60

accatgtacc gagcacttcg gctcctcgcg cgctcgcgtc ccctcgtgcg ggctccagcc    120

gcagccttag cttcggctcc cggcttgggt ggcgcggccg tgccctcgtt ttggcctccg    180

aacgcggctc gaatggcaag ccaaaattcc ttccggatag aatatgatac ctttggtgaa    240

ctaaaggtgc caaatgataa gtattatggc gcccagaccg tgagatctac gatgaacttt    300

aagattggag gtgtgacaga acgcatgcca accccagtta ttaaagcttt tggcatcttg    360

aagcgagcgg ccgctgaagt aaaccaggat tatggtcttg atccaaagat tgctaatgca    420

ataatgaagg cagcagatga ggtagctgaa ggtaaattaa atgatcattt tcctctcgtg    480

gtatggcaga ctggatcagg aactcagaca aatatgaatg taaatgaagt cattagcaat    540

agagcaattg aaatgttagg aggtgaactt ggcagcaaga tacctgtgca tcccaacgat    600

catgttaata aaagccagag ctcaaatgat acttttccca cagcaatgca cattgctgct    660

gcaatagaag ttcatgaagt actgttacca ggactacaga agttacatga tgctcttgat    720

gcaaaatcca aagagtttgc acagatcatc aagattggac gtactcatac tcaggatgct    780

gttccactta ctcttgggca ggaatttagt ggttatgttc aacaagtaaa atatgcaatg    840

acaagaataa aagctgccat gccaagaatc tatgagctcg cagctggagg cactgctgtt    900

ggtacaggtt taaatactag aattggcttt gcagaaaagg ttgctgcaaa agtggctgca    960

cttacaggct tgccttttgt cactgctccg aataaatttg aagctctggc tgctcatgac   1020

gctctggttg agctcagtgg agccatgaac actactgcct gcagtctgat gaagatagca   1080

aatgatattc gatttttggg ttctggtcct cggtcaggtc tgggagaatt gatcttgcct   1140

gaaaatgaac caggaagcag tatcatgcca ggcaaggtga accctactca gtgtgaagca   1200

atgaccatgg ttgcagccca agtcatgggg aaccatgttg ctgtcactgt cggaggcagc   1260

aatggacatt ttgagttgaa tgttttcaag ccaatgatga ttaaaaatgt gttacactca   1320

gccaggctgc tgggggatgc ttcagtttcc tttacagaaa actgcgtggt gggaatccag   1380

gccaatacag aaaggatcaa caagctgatg aatgagtctc taatgttggt gacagctctc   1440

aatcctcata tagggtatga caaggcagca aagattgcta agacagcaca caaaaatgga   1500

tcaaccttaa aggaaactgc tatcgaactt ggctatctca cagcagagca gtttgacgaa   1560

tgggtaaaac ctaaggacat gctgggtcca aagtgattta cataaattta taatgaaaat   1620

aaacatgtat aaaatttaaa aaaacagact cccatttctt aaaaacggat aagtttgaaa   1680

ggaaactgct attgaactta agcatctcta gcagagcaat ttgatcagta tataaaaccc   1740

taggatgtgc taggtctaag atggattaaa caagtataaa ataaaataca tttataaaat   1800

aaaaaggaaa acagactt                                                 1818


<210>  1997
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  1997

Met Tyr Arg Ala Leu Arg Leu Leu Ala Arg Ser Arg Pro Leu Val Arg 
1               5                   10                  15


Ala Pro Ala Ala Ala Leu Ala Ser Ala Pro Gly Leu Gly Gly Ala Ala 
            20                  25                  30


Val Pro Ser Phe Trp Pro Pro Asn Ala Ala Arg Met Ala Ser Gln Asn 
        35                  40                  45


Ser Phe Arg Ile Glu Tyr Asp Thr Phe Gly Glu Leu Lys Val Pro Asn 
    50                  55                  60


Asp Lys Tyr Tyr Gly Ala Gln Thr Val Arg Ser Thr Met Asn Phe Lys 
65                  70                  75                  80


Ile Gly Gly Val Thr Glu Arg Met Pro Thr Pro Val Ile Lys Ala Phe 
                85                  90                  95


Gly Ile Leu Lys Arg Ala Ala Ala Glu Val Asn Gln Asp Tyr Gly Leu 
            100                 105                 110


Asp Pro Lys Ile Ala Asn Ala Ile Met Lys Ala Ala Asp Glu Val Ala 
        115                 120                 125


Glu Gly Lys Leu Asn Asp His Phe Pro Leu Val Val Trp Gln Thr Gly 
    130                 135                 140


Ser Gly Thr Gln Thr Asn Met Asn Val Asn Glu Val Ile Ser Asn Arg 
145                 150                 155                 160


Ala Ile Glu Met Leu Gly Gly Glu Leu Gly Ser Lys Ile Pro Val His 
                165                 170                 175


Pro Asn Asp His Val Asn Lys Ser Gln Ser Ser Asn Asp Thr Phe Pro 
            180                 185                 190


Thr Ala Met His Ile Ala Ala Ala Ile Glu Val His Glu Val Leu Leu 
        195                 200                 205


Pro Gly Leu Gln Lys Leu His Asp Ala Leu Asp Ala Lys Ser Lys Glu 
    210                 215                 220


Phe Ala Gln Ile Ile Lys Ile Gly Arg Thr His Thr Gln Asp Ala Val 
225                 230                 235                 240


Pro Leu Thr Leu Gly Gln Glu Phe Ser Gly Tyr Val Gln Gln Val Lys 
                245                 250                 255


Tyr Ala Met Thr Arg Ile Lys Ala Ala Met Pro Arg Ile Tyr Glu Leu 
            260                 265                 270


Ala Ala Gly Gly Thr Ala Val Gly Thr Gly Leu Asn Thr Arg Ile Gly 
        275                 280                 285


Phe Ala Glu Lys Val Ala Ala Lys Val Ala Ala Leu Thr Gly Leu Pro 
    290                 295                 300


Phe Val Thr Ala Pro Asn Lys Phe Glu Ala Leu Ala Ala His Asp Ala 
305                 310                 315                 320


Leu Val Glu Leu Ser Gly Ala Met Asn Thr Thr Ala Cys Ser Leu Met 
                325                 330                 335


Lys Ile Ala Asn Asp Ile Arg Phe Leu Gly Ser Gly Pro Arg Ser Gly 
            340                 345                 350


Leu Gly Glu Leu Ile Leu Pro Glu Asn Glu Pro Gly Ser Ser Ile Met 
        355                 360                 365


Pro Gly Lys Val Asn Pro Thr Gln Cys Glu Ala Met Thr Met Val Ala 
    370                 375                 380


Ala Gln Val Met Gly Asn His Val Ala Val Thr Val Gly Gly Ser Asn 
385                 390                 395                 400


Gly His Phe Glu Leu Asn Val Phe Lys Pro Met Met Ile Lys Asn Val 
                405                 410                 415


Leu His Ser Ala Arg Leu Leu Gly Asp Ala Ser Val Ser Phe Thr Glu 
            420                 425                 430


Asn Cys Val Val Gly Ile Gln Ala Asn Thr Glu Arg Ile Asn Lys Leu 
        435                 440                 445


Met Asn Glu Ser Leu Met Leu Val Thr Ala Leu Asn Pro His Ile Gly 
    450                 455                 460


Tyr Asp Lys Ala Ala Lys Ile Ala Lys Thr Ala His Lys Asn Gly Ser 
465                 470                 475                 480


Thr Leu Lys Glu Thr Ala Ile Glu Leu Gly Tyr Leu Thr Ala Glu Gln 
                485                 490                 495


Phe Asp Glu Trp Val Lys Pro Lys Asp Met Leu Gly Pro Lys 
            500                 505                 510


<210>  1998
<211>  1637
<212>  DNA
<213>  Homo sapiens

<400>  1998
gacaaccggc gtggaggcgt ggccacagcc gcccagaaat tctacccaag ctccctcagc     60

accatgtacc gagcacttcg gctcctcgcg cgctcgcgtc ccctcgtgcg ggctccagcc    120

gcagccttag cttcggctcc cggcttgggt ggcgcggccg tgccctcgtt ttggcctccg    180

aacgcggctc gaatggcaag ccaaaattcc ttccggatag aatatgatac ctttggtgaa    240

ctaaaggtgc caaatgataa gtattatggc gcccagaccg tgagatctac gatgaacttt    300

aagattggag gtgtgacaga acgcatgcca accccagtta ttaaagcttt tggcatcttg    360

aagcgagcgg ccgctgaagt aaaccaggat tatggtcttg atccaaagat tgctaatgca    420

ataatgaagg cagcagatga ggtagctgaa ggtaaattaa atgatcattt tcctctcgtg    480

gtatggcaga ctggatcagg aactcagaca aatatgaatg taaatgaagt cattagcaat    540

agagcaattg aaatgttagg aggtgaactt ggcagcaaga tacctgtgca tcccaacgat    600

catgttaata aaagccagag ctcaaatgat acttttccca cagcaatgca cattgctgct    660

gcaatagaag ttcatgaagt actgttacca ggactacaga agttacatga tgctcttgat    720

gcaaaatcca aagagtttgc acagatcatc aagattggac gtactcatac tcaggatgct    780

gttccactta ctcttgggca ggaatttagt ggttatgttc aacaagtaaa atatgcaatg    840

acaagaataa aagctgccat gccaagaatc tatgagctcg cagctggagg cactgctgtt    900

ggtacaggtt taaatactag aattggcttt gcagaaaagg ttgctgcaaa agtggctgca    960

cttacaggct tgccttttgt cactgctccg aataaatttg aagctctggc tgctcatgac   1020

gctctggttg agctcagtgg agccatgaac actactgcct gcagtctgat gaagatagca   1080

aatgatattc gatttttggg ttctggtcct cggtcaggtc tgggagaatt gatcttgcct   1140

gaaaatgaac caggaagcag tatcatgcca ggcaaggtga accctactca gtgtgaagca   1200

atgaccatgg ttgcagccca agtcatgggg aaccatgttg ctgtcactgt cggaggcagc   1260

aatggacatt ttgagttgaa tgttttcaag ccaatgatga ttaaaaatgt gttacactca   1320

gccaggctgc tgggggatgc ttcagtttcc tttacagaaa actgcgtggt gggaatccag   1380

gccaatacag aaaggatcaa caagctgatg aatgagtctc taatgttggt gacagctctc   1440

aatcctcata tagggtatga caaggcagca aagattgcta agacagcaca caaaaatgga   1500

tcaaccttaa aggaaactgc tatcgaactt ggctatctca cagcagagca gtttgacgaa   1560

tgggtaaaac ctaaggacat gctgggtcca aagtgattta cataaattta taatgaaaat   1620

aaacatgtat aaaattt                                                  1637


<210>  1999
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  1999

Met Tyr Arg Ala Leu Arg Leu Leu Ala Arg Ser Arg Pro Leu Val Arg 
1               5                   10                  15


Ala Pro Ala Ala Ala Leu Ala Ser Ala Pro Gly Leu Gly Gly Ala Ala 
            20                  25                  30


Val Pro Ser Phe Trp Pro Pro Asn Ala Ala Arg Met Ala Ser Gln Asn 
        35                  40                  45


Ser Phe Arg Ile Glu Tyr Asp Thr Phe Gly Glu Leu Lys Val Pro Asn 
    50                  55                  60


Asp Lys Tyr Tyr Gly Ala Gln Thr Val Arg Ser Thr Met Asn Phe Lys 
65                  70                  75                  80


Ile Gly Gly Val Thr Glu Arg Met Pro Thr Pro Val Ile Lys Ala Phe 
                85                  90                  95


Gly Ile Leu Lys Arg Ala Ala Ala Glu Val Asn Gln Asp Tyr Gly Leu 
            100                 105                 110


Asp Pro Lys Ile Ala Asn Ala Ile Met Lys Ala Ala Asp Glu Val Ala 
        115                 120                 125


Glu Gly Lys Leu Asn Asp His Phe Pro Leu Val Val Trp Gln Thr Gly 
    130                 135                 140


Ser Gly Thr Gln Thr Asn Met Asn Val Asn Glu Val Ile Ser Asn Arg 
145                 150                 155                 160


Ala Ile Glu Met Leu Gly Gly Glu Leu Gly Ser Lys Ile Pro Val His 
                165                 170                 175


Pro Asn Asp His Val Asn Lys Ser Gln Ser Ser Asn Asp Thr Phe Pro 
            180                 185                 190


Thr Ala Met His Ile Ala Ala Ala Ile Glu Val His Glu Val Leu Leu 
        195                 200                 205


Pro Gly Leu Gln Lys Leu His Asp Ala Leu Asp Ala Lys Ser Lys Glu 
    210                 215                 220


Phe Ala Gln Ile Ile Lys Ile Gly Arg Thr His Thr Gln Asp Ala Val 
225                 230                 235                 240


Pro Leu Thr Leu Gly Gln Glu Phe Ser Gly Tyr Val Gln Gln Val Lys 
                245                 250                 255


Tyr Ala Met Thr Arg Ile Lys Ala Ala Met Pro Arg Ile Tyr Glu Leu 
            260                 265                 270


Ala Ala Gly Gly Thr Ala Val Gly Thr Gly Leu Asn Thr Arg Ile Gly 
        275                 280                 285


Phe Ala Glu Lys Val Ala Ala Lys Val Ala Ala Leu Thr Gly Leu Pro 
    290                 295                 300


Phe Val Thr Ala Pro Asn Lys Phe Glu Ala Leu Ala Ala His Asp Ala 
305                 310                 315                 320


Leu Val Glu Leu Ser Gly Ala Met Asn Thr Thr Ala Cys Ser Leu Met 
                325                 330                 335


Lys Ile Ala Asn Asp Ile Arg Phe Leu Gly Ser Gly Pro Arg Ser Gly 
            340                 345                 350


Leu Gly Glu Leu Ile Leu Pro Glu Asn Glu Pro Gly Ser Ser Ile Met 
        355                 360                 365


Pro Gly Lys Val Asn Pro Thr Gln Cys Glu Ala Met Thr Met Val Ala 
    370                 375                 380


Ala Gln Val Met Gly Asn His Val Ala Val Thr Val Gly Gly Ser Asn 
385                 390                 395                 400


Gly His Phe Glu Leu Asn Val Phe Lys Pro Met Met Ile Lys Asn Val 
                405                 410                 415


Leu His Ser Ala Arg Leu Leu Gly Asp Ala Ser Val Ser Phe Thr Glu 
            420                 425                 430


Asn Cys Val Val Gly Ile Gln Ala Asn Thr Glu Arg Ile Asn Lys Leu 
        435                 440                 445


Met Asn Glu Ser Leu Met Leu Val Thr Ala Leu Asn Pro His Ile Gly 
    450                 455                 460


Tyr Asp Lys Ala Ala Lys Ile Ala Lys Thr Ala His Lys Asn Gly Ser 
465                 470                 475                 480


Thr Leu Lys Glu Thr Ala Ile Glu Leu Gly Tyr Leu Thr Ala Glu Gln 
                485                 490                 495


Phe Asp Glu Trp Val Lys Pro Lys Asp Met Leu Gly Pro Lys 
            500                 505                 510


<210>  2000
<211>  833
<212>  DNA
<213>  Homo sapiens

<400>  2000
gacaaccggc gtggaggcgt ggccacagcc gcccagaaat tctacccaag ctccctcagc     60

accatgtacc gagcacttcg gctcctcgcg cgctcgcgtc ccctcgtgcg ggctccagcc    120

gcagccttag cttcggctcc cggcttgggt ggcgcggccg tgccctcgtt ttggcctccg    180

aacgcggctc gaatggcaag ccaaaattcc ttccggatag aatatgatac ctttggtgaa    240

ctaaaggtgc caaatgataa gtattatggc gcccagaccg tgagatctac gatgaacttt    300

aagattggag gtgtgacaga acgcatgcca accccagtta ttaaagcttt tggcatcttg    360

aagcgagcgg ccgctgaagt aaaccaggat tatggtcttg atccaaagat tgctaatgca    420

ataatgaagg cagcagatga ggtagctgaa ggtaaattaa atgatcattt tcctctcgtg    480

gtatggcaga ctggatcagg aactcagaca aatatgaatg taaatgaagt cattagcaat    540

agagcaattg aaatgttagg aggtgaactt ggcagcaaga tacctgtgca tcccaacgat    600

catgttaata aaagccagag ctcaaatgat acttttccca cagcaatgca cattgctgct    660

gcaatagaag ttcatgaagt actgttacca ggactacaga agttacatga tgctcttgat    720

gcaaaatcca aagagtttgc acagatcatc aagattggac gtactcatac tcaggatgct    780

gttccactta ctcttgggca ggtataggag tttgactaat ttgattcaat tta           833


<210>  2001
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  2001

Met Tyr Arg Ala Leu Arg Leu Leu Ala Arg Ser Arg Pro Leu Val Arg 
1               5                   10                  15


Ala Pro Ala Ala Ala Leu Ala Ser Ala Pro Gly Leu Gly Gly Ala Ala 
            20                  25                  30


Val Pro Ser Phe Trp Pro Pro Asn Ala Ala Arg Met Ala Ser Gln Asn 
        35                  40                  45


Ser Phe Arg Ile Glu Tyr Asp Thr Phe Gly Glu Leu Lys Val Pro Asn 
    50                  55                  60


Asp Lys Tyr Tyr Gly Ala Gln Thr Val Arg Ser Thr Met Asn Phe Lys 
65                  70                  75                  80


Ile Gly Gly Val Thr Glu Arg Met Pro Thr Pro Val Ile Lys Ala Phe 
                85                  90                  95


Gly Ile Leu Lys Arg Ala Ala Ala Glu Val Asn Gln Asp Tyr Gly Leu 
            100                 105                 110


Asp Pro Lys Ile Ala Asn Ala Ile Met Lys Ala Ala Asp Glu Val Ala 
        115                 120                 125


Glu Gly Lys Leu Asn Asp His Phe Pro Leu Val Val Trp Gln Thr Gly 
    130                 135                 140


Ser Gly Thr Gln Thr Asn Met Asn Val Asn Glu Val Ile Ser Asn Arg 
145                 150                 155                 160


Ala Ile Glu Met Leu Gly Gly Glu Leu Gly Ser Lys Ile Pro Val His 
                165                 170                 175


Pro Asn Asp His Val Asn Lys Ser Gln Ser Ser Asn Asp Thr Phe Pro 
            180                 185                 190


Thr Ala Met His Ile Ala Ala Ala Ile Glu Val His Glu Val Leu Leu 
        195                 200                 205


Pro Gly Leu Gln Lys Leu His Asp Ala Leu Asp Ala Lys Ser Lys Glu 
    210                 215                 220


Phe Ala Gln Ile Ile Lys Ile Gly Arg Thr His Thr Gln Asp Ala Val 
225                 230                 235                 240


Pro Leu Thr Leu Gly Gln Val 
                245


<210>  2002
<211>  956
<212>  DNA
<213>  Homo sapiens

<400>  2002
aagatgtttt tggacttcag atgagaaggg ctccattcat ggttaatcat gaatgaaaac     60

gaaactaaga atatatgctg tagaaaaaga agaagaaaag ccacaagact gcttaaaaat    120

ttctgtgtct tacacagaag atagaaaaaa tagagtgtct ccaattggat ggatttttta    180

aaaaatttgg ttattgtaat ggatttattt tttcttagag ctgagctgat tgtactttgg    240

ccaactaatg ggttaatact gtcaagggaa attagccctg actaaacatt gccgctggct    300

catgaatgca ctaggcttgg ggcagtataa aaactcagag aaatcagtgt gtaggagaca    360

cagaaatcag tgtcactcag tgacagaagc aacaataatt gtgaaaaata cttcagcagt    420

tatggactca tctgtcattc aaaggaaaaa agtagctgtc attggtggtg gcttggttgg    480

ctcattacaa gcatgctttc ttgcaaagag gaatttccag attgatgtat atgaagctag    540

ggaagatact cgagtggcta ccttcacacg tggaagaagc attaacttag ccctttctca    600

tagaggacga caagccttga aagctgttgg cctggaagat caggtactta atgtatcttt    660

cttacagaag ataatacctg gtatttttca acaattgcat ggtttgattt catcctggct    720

taaaaagtac catttaatac caagaatctc tgcatgaaaa ctcattctac taaagctttt    780

aaaattcgaa atttggcaag agggtgaaca ttggacactc gaggcacccg aggaggaccc    840

tgcaaccgga tgattgcttc tgatattggg ttctcaacag gatggtgcgt cactgcctgt    900

agaaagtgag agtcaagatg gcatccagga taaaaggagc cagattcctt tttttt        956


<210>  2003
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  2003

Met Asn Ala Leu Gly Leu Gly Gln Tyr Lys Asn Ser Glu Lys Ser Val 
1               5                   10                  15


Cys Arg Arg His Arg Asn Gln Cys His Ser Val Thr Glu Ala Thr Ile 
            20                  25                  30


Ile Val Lys Asn Thr Ser Ala Val Met Asp Ser Ser Val Ile Gln Arg 
        35                  40                  45


Lys Lys Val Ala Val Ile Gly Gly Gly Leu Val Gly Ser Leu Gln Ala 
    50                  55                  60


Cys Phe Leu Ala Lys Arg Asn Phe Gln Ile Asp Val Tyr Glu Ala Arg 
65                  70                  75                  80


Glu Asp Thr Arg Val Ala Thr Phe Thr Arg Gly Arg Ser Ile Asn Leu 
                85                  90                  95


Ala Leu Ser His Arg Gly Arg Gln Ala Leu Lys Ala Val Gly Leu Glu 
            100                 105                 110


Asp Gln Val Leu Asn Val Ser Phe Leu Gln Lys Ile Ile Pro Gly Ile 
        115                 120                 125


Phe Gln Gln Leu His Gly Leu Ile Ser Ser Trp Leu Lys Lys Tyr His 
    130                 135                 140


Leu Ile Pro Arg Ile Ser Ala 
145                 150


<210>  2004
<211>  2016
<212>  DNA
<213>  Homo sapiens

<400>  2004
aagatgtttt tggacttcag atgagaaggg ctccattcat ggttaatcat gaatgaaaac     60

gaaactaaga atatatgctg tagaaaaaga agaagaaaag ccacaagact gcttaaaaat    120

ttctgtgtct tacacagaag atagaaaaaa tagagtgtct ccaattggat ggatttttta    180

aaaaatttgg ttattgtaat ggatttattt tttcttagag ctgagctgat tgtactttgg    240

ccaactaatg ggttaatact gtcaagggaa attagccctg actaaacatt gccgctggct    300

catgaatgca ctaggcttgg ggcagtataa aaactcagag aaatcagtgt gtaggagaca    360

cagaaatcag tgtcactcag tgacagaagc aacaataatt gtgaaaaata cttcagcagt    420

tatggactca tctgtcattc aaaggaaaaa agtagctgtc attggtggtg gcttggttgg    480

ctcattacaa gcatgctttc ttgcaaagag gaatttccag attgatgtat atgaagctag    540

ggaagatact cgagtggcta ccttcacacg tggaagaagc attaacttag ccctttctca    600

tagaggacga caagccttga aagctgttgg cctggaagat cagattgtat cccaaggtat    660

tcccatgaga gcaagaatga tccactctct ttcaggaaaa aagtctgcaa ttccctatgg    720

gacaaagtct cagtatattc tttctgtaag cagagaaaat ctaaacaagg atctattgac    780

tgctgctgag aaatacccca atgtgaaaat gcactttaac cacaggctgt tgaaatgtaa    840

tccagaggaa ggaatgatca cagtgcttgg atctgacaaa gttcccaaag atgtcacttg    900

tgacctcatt gtaggatgtg atggagccta ttcaactgtc agatctcacc tgatgaagaa    960

acctcgcttt gattacagtc agcagtacat tcctcatggg tacatggagt tgactattcc   1020

acctaagaac ggagattatg ccatggaacc taattatctg catatttggc ctagaaatac   1080

ctttatgatg attgcacttc ctaacatgaa caaatcattc acatgtactt tgttcatgcc   1140

ctttgaagag tttgaaaaac ttctaaccag taatgatgtg gtagatttct tccagaaata   1200

ctttccggat gccatccctc taattggaga gaaactccta gtgcaagatt tcttcctgtt   1260

gcctgcccag cccatgatat ctgtaaagtg ctcttcattt cactttaaat ctcactgtgt   1320

actgctggga gatgcagctc atgctatagt gccgtttttt gggcaaggaa tgaatgcggg   1380

ctttgaagac tgcttggtat ttgatgagtt aatggataaa ttcagtaacg accttagttt   1440

gtgtcttcct gtgttctcaa gattgagaat cccagatgat cacgcgattt cagacctatc   1500

catgtacaat tacatagaga tgcgagcaca tgtcaactca agctggttca tttttcagaa   1560

gaacatggag agatttcttc atgcgattat gccatcgacc tttatccctc tctatacaat   1620

ggtcactttt tccagaataa gataccatga ggctgtgcag cgttggcatt ggcaaaaaaa   1680

ggtgataaac aaaggactct ttttcttggg atcactgata gccatcagca gtacctacct   1740

acttatacac tacatgtcac cacgatcttt cctccgcttg agaagaccat ggaactggat   1800

agctcacttc cggaatacaa catgtttccc cgcaaaggcc gtggactccc tagaacaaat   1860

ttccaatctc attagcaggt gatagaaagg ttttgtggta gcaaatgcat gatttctctg   1920

tgaccaaaat taagcatgaa aaaaatgttt ccattgccat atttgattca ctagtggaag   1980

atagtgttct gcttataatt aaactgaatg tagagt                             2016


<210>  2005
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  2005

Met Asn Ala Leu Gly Leu Gly Gln Tyr Lys Asn Ser Glu Lys Ser Val 
1               5                   10                  15


Cys Arg Arg His Arg Asn Gln Cys His Ser Val Thr Glu Ala Thr Ile 
            20                  25                  30


Ile Val Lys Asn Thr Ser Ala Val Met Asp Ser Ser Val Ile Gln Arg 
        35                  40                  45


Lys Lys Val Ala Val Ile Gly Gly Gly Leu Val Gly Ser Leu Gln Ala 
    50                  55                  60


Cys Phe Leu Ala Lys Arg Asn Phe Gln Ile Asp Val Tyr Glu Ala Arg 
65                  70                  75                  80


Glu Asp Thr Arg Val Ala Thr Phe Thr Arg Gly Arg Ser Ile Asn Leu 
                85                  90                  95


Ala Leu Ser His Arg Gly Arg Gln Ala Leu Lys Ala Val Gly Leu Glu 
            100                 105                 110


Asp Gln Ile Val Ser Gln Gly Ile Pro Met Arg Ala Arg Met Ile His 
        115                 120                 125


Ser Leu Ser Gly Lys Lys Ser Ala Ile Pro Tyr Gly Thr Lys Ser Gln 
    130                 135                 140


Tyr Ile Leu Ser Val Ser Arg Glu Asn Leu Asn Lys Asp Leu Leu Thr 
145                 150                 155                 160


Ala Ala Glu Lys Tyr Pro Asn Val Lys Met His Phe Asn His Arg Leu 
                165                 170                 175


Leu Lys Cys Asn Pro Glu Glu Gly Met Ile Thr Val Leu Gly Ser Asp 
            180                 185                 190


Lys Val Pro Lys Asp Val Thr Cys Asp Leu Ile Val Gly Cys Asp Gly 
        195                 200                 205


Ala Tyr Ser Thr Val Arg Ser His Leu Met Lys Lys Pro Arg Phe Asp 
    210                 215                 220


Tyr Ser Gln Gln Tyr Ile Pro His Gly Tyr Met Glu Leu Thr Ile Pro 
225                 230                 235                 240


Pro Lys Asn Gly Asp Tyr Ala Met Glu Pro Asn Tyr Leu His Ile Trp 
                245                 250                 255


Pro Arg Asn Thr Phe Met Met Ile Ala Leu Pro Asn Met Asn Lys Ser 
            260                 265                 270


Phe Thr Cys Thr Leu Phe Met Pro Phe Glu Glu Phe Glu Lys Leu Leu 
        275                 280                 285


Thr Ser Asn Asp Val Val Asp Phe Phe Gln Lys Tyr Phe Pro Asp Ala 
    290                 295                 300


Ile Pro Leu Ile Gly Glu Lys Leu Leu Val Gln Asp Phe Phe Leu Leu 
305                 310                 315                 320


Pro Ala Gln Pro Met Ile Ser Val Lys Cys Ser Ser Phe His Phe Lys 
                325                 330                 335


Ser His Cys Val Leu Leu Gly Asp Ala Ala His Ala Ile Val Pro Phe 
            340                 345                 350


Phe Gly Gln Gly Met Asn Ala Gly Phe Glu Asp Cys Leu Val Phe Asp 
        355                 360                 365


Glu Leu Met Asp Lys Phe Ser Asn Asp Leu Ser Leu Cys Leu Pro Val 
    370                 375                 380


Phe Ser Arg Leu Arg Ile Pro Asp Asp His Ala Ile Ser Asp Leu Ser 
385                 390                 395                 400


Met Tyr Asn Tyr Ile Glu Met Arg Ala His Val Asn Ser Ser Trp Phe 
                405                 410                 415


Ile Phe Gln Lys Asn Met Glu Arg Phe Leu His Ala Ile Met Pro Ser 
            420                 425                 430


Thr Phe Ile Pro Leu Tyr Thr Met Val Thr Phe Ser Arg Ile Arg Tyr 
        435                 440                 445


His Glu Ala Val Gln Arg Trp His Trp Gln Lys Lys Val Ile Asn Lys 
    450                 455                 460


Gly Leu Phe Phe Leu Gly Ser Leu Ile Ala Ile Ser Ser Thr Tyr Leu 
465                 470                 475                 480


Leu Ile His Tyr Met Ser Pro Arg Ser Phe Leu Arg Leu Arg Arg Pro 
                485                 490                 495


Trp Asn Trp Ile Ala His Phe Arg Asn Thr Thr Cys Phe Pro Ala Lys 
            500                 505                 510


Ala Val Asp Ser Leu Glu Gln Ile Ser Asn Leu Ile Ser Arg 
        515                 520                 525


<210>  2006
<211>  1978
<212>  DNA
<213>  Homo sapiens

<400>  2006
aagatgtttt tggacttcag atgagaaggg ctccattcat ggttaatcat gaatgaaaac     60

gaaactaaga atatatgctg tagaaaaaga agaagaaaag ccacaagact gcttaaaaat    120

ttctgtgtct tacacagaag atagaaaaaa tagagtgtct ccaattggat ggatttttta    180

aaaaatttgg ttattgtaat ggatttattt tttcttagag ctgagctgat tgtactttgg    240

ccaactaatg ggttaatact gtcaagggaa attagccctg actaaacatt gccgctggct    300

catgaatgca ctaggcttgg ggcagtataa aaactcagag aaatcagtgt gtaggagaca    360

cagaaatcag tgtcactcag tgacagaagc aacaataatt gtgaaaaata cttcagcagt    420

tatggactca tctgtcattc aaaggaaaaa agtagctgtc attggtggtg gcttggttgg    480

ctcattacaa gcatgctttc ttgcaaagag gaatttccag attgatgtat atgaagctag    540

ggaagatact cgagtggcta ccttcacacg tggaagaagc attaacttag ccctttctca    600

tagaggacga caagccttga aagctgttgg cctggaagat cagattgtat cccaaggtat    660

tcccatgaga gcaagaatga tccactctct ttcaggaaaa aagtctgcaa ttccctatgg    720

gacaaagtct cagtatattc tttctgtaag cagagaaaat ctaaacaagg atctattgac    780

tgctgctgag aaatacccca atgtgaaaat gcactttaac cacaggctgt tgaaatgtaa    840

tccagaggaa ggaatgatca cagtgcttgg atctgacaaa gttcccaaag atgtcacttg    900

tgacctcatt gtaggatgtg atggagccta ttcaactgtc agatctcacc tgatgaagaa    960

acctcgcttt gattacagtc agcagtacat tcctcatggg tacatggagt tgactattcc   1020

acctaagaac ggagattatg ccatggaacc taattatctg catatttggc ctagaaatac   1080

ctttatgatg attgcacttc ctaacatgaa caaatcattc acatgtactt tgttcatgcc   1140

ctttgaagag tttgaaaaac ttctaaccag taatgatgtg gtagatttct tccagaaata   1200

ctttccggat gccatccctc taattggaga gaaactccta gtgcaagatt tcttcctgtt   1260

gcctgcccag cccatgatat ctgtaaagtg ctcttcattt cactttaaat ctcactgtgt   1320

actgctggga gatgcagctc atgctatagt gccgtttttt gggcaaggaa tgaatgcggg   1380

ctttgaagac tgcttggtat ttgatgagtt aatggataaa ttcagtaacg accttagttt   1440

gtgtcttcct gtgttctcaa gattgagaat cccagatgat cacgcgattt cagacctatc   1500

catgtacaat tacatagaga agaacatgga gagatttctt catgcgatta tgccatcgac   1560

ctttatccct ctctatacaa tggtcacttt ttccagaata agataccatg aggctgtgca   1620

gcgttggcat tggcaaaaaa aggtgataaa caaaggactc tttttcttgg gatcactgat   1680

agccatcagc agtacctacc tacttataca ctacatgtca ccacgatctt tcctccgctt   1740

gagaagacca tggaactgga tagctcactt ccggaataca acatgtttcc ccgcaaaggc   1800

cgtggactcc ctagaacaaa tttccaatct cattagcagg tgatagaaag gttttgtggt   1860

agcaaatgca tgatttctct gtgaccaaaa ttaagcatga aaaaaatgtt tccattgcca   1920

tatttgattc actagtggaa gatagtgttc tgcttataat taaactgaat gtagagta     1978


<210>  2007
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  2007

Met Asn Ala Leu Gly Leu Gly Gln Tyr Lys Asn Ser Glu Lys Ser Val 
1               5                   10                  15


Cys Arg Arg His Arg Asn Gln Cys His Ser Val Thr Glu Ala Thr Ile 
            20                  25                  30


Ile Val Lys Asn Thr Ser Ala Val Met Asp Ser Ser Val Ile Gln Arg 
        35                  40                  45


Lys Lys Val Ala Val Ile Gly Gly Gly Leu Val Gly Ser Leu Gln Ala 
    50                  55                  60


Cys Phe Leu Ala Lys Arg Asn Phe Gln Ile Asp Val Tyr Glu Ala Arg 
65                  70                  75                  80


Glu Asp Thr Arg Val Ala Thr Phe Thr Arg Gly Arg Ser Ile Asn Leu 
                85                  90                  95


Ala Leu Ser His Arg Gly Arg Gln Ala Leu Lys Ala Val Gly Leu Glu 
            100                 105                 110


Asp Gln Ile Val Ser Gln Gly Ile Pro Met Arg Ala Arg Met Ile His 
        115                 120                 125


Ser Leu Ser Gly Lys Lys Ser Ala Ile Pro Tyr Gly Thr Lys Ser Gln 
    130                 135                 140


Tyr Ile Leu Ser Val Ser Arg Glu Asn Leu Asn Lys Asp Leu Leu Thr 
145                 150                 155                 160


Ala Ala Glu Lys Tyr Pro Asn Val Lys Met His Phe Asn His Arg Leu 
                165                 170                 175


Leu Lys Cys Asn Pro Glu Glu Gly Met Ile Thr Val Leu Gly Ser Asp 
            180                 185                 190


Lys Val Pro Lys Asp Val Thr Cys Asp Leu Ile Val Gly Cys Asp Gly 
        195                 200                 205


Ala Tyr Ser Thr Val Arg Ser His Leu Met Lys Lys Pro Arg Phe Asp 
    210                 215                 220


Tyr Ser Gln Gln Tyr Ile Pro His Gly Tyr Met Glu Leu Thr Ile Pro 
225                 230                 235                 240


Pro Lys Asn Gly Asp Tyr Ala Met Glu Pro Asn Tyr Leu His Ile Trp 
                245                 250                 255


Pro Arg Asn Thr Phe Met Met Ile Ala Leu Pro Asn Met Asn Lys Ser 
            260                 265                 270


Phe Thr Cys Thr Leu Phe Met Pro Phe Glu Glu Phe Glu Lys Leu Leu 
        275                 280                 285


Thr Ser Asn Asp Val Val Asp Phe Phe Gln Lys Tyr Phe Pro Asp Ala 
    290                 295                 300


Ile Pro Leu Ile Gly Glu Lys Leu Leu Val Gln Asp Phe Phe Leu Leu 
305                 310                 315                 320


Pro Ala Gln Pro Met Ile Ser Val Lys Cys Ser Ser Phe His Phe Lys 
                325                 330                 335


Ser His Cys Val Leu Leu Gly Asp Ala Ala His Ala Ile Val Pro Phe 
            340                 345                 350


Phe Gly Gln Gly Met Asn Ala Gly Phe Glu Asp Cys Leu Val Phe Asp 
        355                 360                 365


Glu Leu Met Asp Lys Phe Ser Asn Asp Leu Ser Leu Cys Leu Pro Val 
    370                 375                 380


Phe Ser Arg Leu Arg Ile Pro Asp Asp His Ala Ile Ser Asp Leu Ser 
385                 390                 395                 400


Met Tyr Asn Tyr Ile Glu Lys Asn Met Glu Arg Phe Leu His Ala Ile 
                405                 410                 415


Met Pro Ser Thr Phe Ile Pro Leu Tyr Thr Met Val Thr Phe Ser Arg 
            420                 425                 430


Ile Arg Tyr His Glu Ala Val Gln Arg Trp His Trp Gln Lys Lys Val 
        435                 440                 445


Ile Asn Lys Gly Leu Phe Phe Leu Gly Ser Leu Ile Ala Ile Ser Ser 
    450                 455                 460


Thr Tyr Leu Leu Ile His Tyr Met Ser Pro Arg Ser Phe Leu Arg Leu 
465                 470                 475                 480


Arg Arg Pro Trp Asn Trp Ile Ala His Phe Arg Asn Thr Thr Cys Phe 
                485                 490                 495


Pro Ala Lys Ala Val Asp Ser Leu Glu Gln Ile Ser Asn Leu Ile Ser 
            500                 505                 510


Arg 



<210>  2008
<211>  5376
<212>  DNA
<213>  Homo sapiens

<400>  2008
aagatgtttt tggacttcag atgagaaggg ctccattcat ggttaatcat gaatgaaaac     60

gaaactaaga atatatgctg tagaaaaaga agaagaaaag ccacaagact gcttaaaaat    120

ttctgtgtct tacacagaag atagaaaaaa tagagtgtct ccaattggat ggatttttta    180

aaaaatttgg ttattgtaat ggatttattt tttcttagag ctgagctgat tgtactttgg    240

ccaactaatg ggttaatact gtcaagggaa attagccctg actaaacatt gccgctggct    300

catgaatgca ctaggcttgg ggcagtataa aaactcagag aaatcagtgt gtaggagaca    360

cagaaatcag tgtcactcag tgacagaagc aacaataatt gtgaaaaata cttcagcagt    420

tatggactca tctgtcattc aaaggaaaaa agtagctgtc attggtggtg gcttggttgg    480

ctcattacaa gcatgctttc ttgcaaagag gaatttccag attgatgtat atgaagctag    540

ggaagatact cgagtggcta ccttcacacg tggaagaagc attaacttag ccctttctca    600

tagaggacga caagccttga aagctgttgg cctggaagat cagattgtat cccaaggtat    660

tcccatgaga gcaagaatga tccactctct ttcaggaaaa aagtctgcaa ttccctatgg    720

gacaaagtct cagtatattc tttctgtaag cagagaaaat ctaaacaagg atctattgac    780

tgctgctgag aaatacccca atgtgaaaat gcactttaac cacaggctgt tgaaatgtaa    840

tccagaggaa ggaatgatca cagtgcttgg atctgacaaa gttcccaaag atgtcacttg    900

tgacctcatt gtaggatgtg atggagccta ttcaactgtc agatctcacc tgatgaagaa    960

acctcgcttt gattacagtc agcagtacat tcctcatggg tacatggagt tgactattcc   1020

acctaagaac ggagattatg ccatggaacc taattatctg catatttggc ctagaaatac   1080

ctttatgatg attgcacttc ctaacatgaa caaatcattc acatgtactt tgttcatgcc   1140

ctttgaagag tttgaaaaac ttctaaccag taatgatgtg gtagatttct tccagaaata   1200

ctttccggat gccatccctc taattggaga gaaactccta gtgcaagatt tcttcctgtt   1260

gcctgcccag cccatgatat ctgtaaagtg ctcttcattt cactttaaat ctcactgtgt   1320

actgctggga gatgcagctc atgctatagt gccgtttttt gggcaaggaa tgaatgcggg   1380

ctttgaagac tgcttggtat ttgatgagtt aatggataaa ttcagtaacg accttagttt   1440

gtgtcttcct gtgttctcaa gattgagaat cccagatgat cacgcgattt cagacctatc   1500

catgtacaat tacatagaga tgcgagcaca tgtcaactca agctggttca tttttcagaa   1560

gaacatggag agatttcttc atgcgattat gccatcgacc tttatccctc tctatacaat   1620

ggtcactttt tccagaataa gataccatga ggctgtgcag cgttggcatt ggcaaaaaaa   1680

ggtgataaac aaaggactct ttttcttggg atcactgata gccatcagca gtacctacct   1740

acttatacac tacatgtcac cacgatcttt cctccgcttg agaagaccat ggaactggat   1800

agctcacttc cggaatacaa catgtttccc cgcaaaggcc gtggactccc tagaacaaat   1860

ttccaatctc attagcaggt gatagaaagg ttttgtggta gcaaatgcat gatttctctg   1920

tgaccaaaat taagcatgaa aaaaatgttt ccattgccat atttgattca ctagtggaag   1980

atagtgttct gcttataatt aaactgaatg tagagtatct ctgtatgtta attgcaatta   2040

ctggttgggg ggtgcatttt aaaagatgaa acatgcagct tccctacatt acacacactc   2100

aggttgagtc attctaacta taaaagtgca atgactaaga tccttcactt ctctgaaagt   2160

aaggccctag atgcctcagg gaagacagta atcatgcctt ttctttaaaa gacacaatag   2220

gactcgcaac agcattgact caacacctag gactaaaaat cacaacttaa ctagcatgtt   2280

aactgcactt ttcattacgt gaatggaact tacctaacca cagggctcag acttactaga   2340

taaaaccaga aatggaaata aggaattcag gggagttcca gagacttaca aaatgaactc   2400

attttatttt cccaccttca aatataagta ttatcatcta tctgtttatc gtctatctat   2460

ctatcatcta tctatctatc tatcatctat ctatctatct atctatctat ctatctatct   2520

atctatctct atttatttat gtatttagag atcaggtctc actctgttga ccaggctgga   2580

gtgcagtggt gagatctggg ttcactgcaa cctctgcctc ctgggctcaa gcaatcctcc   2640

cacttcagcc tcccaaatag ctggggctac catggtattt ttcagtagag accgggtctt   2700

gccatgctgc ccaggccagt ctcaaactcc tggcctcatg tgatctgccc acctcagcct   2760

cccaaagtac agggattaga gttgtgagcc accgctgcca gcccagagtt accctctaaa   2820

gataagaaaa aggctattaa tatcatacta agtgaaggac aggaaagggt tttattcata   2880

aattaaatgt ctacatgtgc cagaatggaa aggaaacaag gggagacaac ttttatagaa   2940

atacaaagcc attactttat tcaatttcag accctcagaa gcaatttact aatttattct   3000

tcgactacat actgcagcag aaccagcaat acacttgatt tttaaaagca catttagtga   3060

aatgttttct ttggttcatc cttctttaac aggctgctga gtcactcaga aatccttcaa   3120

acatgattaa ttatgaagat gaaacactag agtcatataa gaaataaaaa ttgggcaata   3180

aaataaaatg attcagtgtt tcttttctat attgtcaatg aaaaccttga gttctaataa   3240

tccatgttca gtttgtaggg aaagaaaaaa taatttttcc ttctacccac tttaggttcc   3300

ttggctgggg cccctataac aaaagacaga ttgacaagag aaaaacaaac ataaatttat   3360

tagcgggtat atgtaatata tatgtgggaa atacagggga atgagcaaat ctcaaagagc   3420

tggcgtctta gaactccctg gcttatatag catcgacaaa gaacagtaaa tttttagaga   3480

aacaacaaaa caaagaaaaa gagctttgag tctgtagggg cagcaatttg ggggaagcaa   3540

atatatggga gtttgccttg tagattcctc tggtgctggt ctccaggctg acaaggattc   3600

aaagttgtct ctgaaactcc tctttgtcat actgcacata taaaacgtct tttgtttcca   3660

acaagaggat tttctttttc attctagaat tatctccttg ataacttgat cagatatagg   3720

acatgacact gaatagagtc caacagtaca aaaaaaattc agtatgttct agctacttca   3780

cacatgtgta cgcgacagtt atttttacag taaggtattt tcgagaaaaa tgcattacgt   3840

gttttggaaa atagagtaat ttaaaaaata tatttgaaat gaaaatctcc aacacattag   3900

aagatgatga tgttagatgc ccatcgtgtg ccacaagtgg ttttttcatt atgtaaagca   3960

cccgttgaat taaaagaatt tgtttttgtt caacctcttc ctgaggccca agagcatatg   4020

ggcaattcgg atttcctgct ggaccacaag gttctgttga tattacatag aacgggtatt   4080

ccagacactt cttatgatga aagtccaaaa gtggcatcca atttaaggcc ccatctttcg   4140

ttgccattct tcattcctac aaaggacgaa cttggattac atcaactttg gacccattgg   4200

ttttgtcgct gtcgtcaact gacagtgatt catcactggt gatgataaaa atgatggaag   4260

aagagttgaa agtcactttt ttctttggcc tgtccccatc tttctgtgac atcacaatgg   4320

gtctgatctg catttcactt ccagctgctg gtaggtcttt agcaggcctc tggcacctca   4380

gcagtcggag gcacagaagc tgcaaaaggg atcttcgaaa ctgggcagag aaaaaataaa   4440

gtggaatatt aagtaaaagt tgggcactaa tctggattaa cattcgagga aatcagttga   4500

gctgaattta agttgttttt tgtttgttag caggtgtgga tgtggggtta tgtggtcatg   4560

ctcagatcta cctaaatcac cccagagctt tatgtctttt attcattcta attcttatta   4620

accggaatat gtaggaccat ttcaatacct tgtaatcctc caagcttcaa tctgcacaca   4680

ctttctatga gggcaggtac aactattaag agattttgaa cattaagtta gtccacaaat   4740

attcagtggg catctactag gtgacagcca ctgtgctata attagagact ttttactata   4800

agcatcaaaa acagataagg ctcttcctgg cagagtttac agcctggtgt acttgctaat   4860

gtctctttaa ttaggtgaag aatttttttt ttctatcgaa attactaatc agttggggaa   4920

aaaaatacta tagcagacag cactaatgtc atcaacaaac attgttcttc tccgtgtcct   4980

gggtacaaca tcgaataata tttcttggcc tcctttccgc ttctcctctc tgctgttcct   5040

ctctacaaga acctgggagg ccaacgccta aagatcataa tatcacacaa tggaaggaac   5100

ctagattcct aaatgactgc ataggacaga tcccatctcc tccacccaat acattattag   5160

actgaactgt gacctgaaat gagcaataaa ctctgtatta attcactgaa atgttggggt   5220

tgcttgttat agtagtcggt ccatcatgac cagtaaaaca taaatcaaaa gttaatgtaa   5280

ttgttatccc attatttaga gcgaaataaa tgttgaatat atggactttc tcagattagg   5340

aaataccaat taaaaatata ataaatagct acattg                             5376


<210>  2009
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  2009

Met Asn Ala Leu Gly Leu Gly Gln Tyr Lys Asn Ser Glu Lys Ser Val 
1               5                   10                  15


Cys Arg Arg His Arg Asn Gln Cys His Ser Val Thr Glu Ala Thr Ile 
            20                  25                  30


Ile Val Lys Asn Thr Ser Ala Val Met Asp Ser Ser Val Ile Gln Arg 
        35                  40                  45


Lys Lys Val Ala Val Ile Gly Gly Gly Leu Val Gly Ser Leu Gln Ala 
    50                  55                  60


Cys Phe Leu Ala Lys Arg Asn Phe Gln Ile Asp Val Tyr Glu Ala Arg 
65                  70                  75                  80


Glu Asp Thr Arg Val Ala Thr Phe Thr Arg Gly Arg Ser Ile Asn Leu 
                85                  90                  95


Ala Leu Ser His Arg Gly Arg Gln Ala Leu Lys Ala Val Gly Leu Glu 
            100                 105                 110


Asp Gln Ile Val Ser Gln Gly Ile Pro Met Arg Ala Arg Met Ile His 
        115                 120                 125


Ser Leu Ser Gly Lys Lys Ser Ala Ile Pro Tyr Gly Thr Lys Ser Gln 
    130                 135                 140


Tyr Ile Leu Ser Val Ser Arg Glu Asn Leu Asn Lys Asp Leu Leu Thr 
145                 150                 155                 160


Ala Ala Glu Lys Tyr Pro Asn Val Lys Met His Phe Asn His Arg Leu 
                165                 170                 175


Leu Lys Cys Asn Pro Glu Glu Gly Met Ile Thr Val Leu Gly Ser Asp 
            180                 185                 190


Lys Val Pro Lys Asp Val Thr Cys Asp Leu Ile Val Gly Cys Asp Gly 
        195                 200                 205


Ala Tyr Ser Thr Val Arg Ser His Leu Met Lys Lys Pro Arg Phe Asp 
    210                 215                 220


Tyr Ser Gln Gln Tyr Ile Pro His Gly Tyr Met Glu Leu Thr Ile Pro 
225                 230                 235                 240


Pro Lys Asn Gly Asp Tyr Ala Met Glu Pro Asn Tyr Leu His Ile Trp 
                245                 250                 255


Pro Arg Asn Thr Phe Met Met Ile Ala Leu Pro Asn Met Asn Lys Ser 
            260                 265                 270


Phe Thr Cys Thr Leu Phe Met Pro Phe Glu Glu Phe Glu Lys Leu Leu 
        275                 280                 285


Thr Ser Asn Asp Val Val Asp Phe Phe Gln Lys Tyr Phe Pro Asp Ala 
    290                 295                 300


Ile Pro Leu Ile Gly Glu Lys Leu Leu Val Gln Asp Phe Phe Leu Leu 
305                 310                 315                 320


Pro Ala Gln Pro Met Ile Ser Val Lys Cys Ser Ser Phe His Phe Lys 
                325                 330                 335


Ser His Cys Val Leu Leu Gly Asp Ala Ala His Ala Ile Val Pro Phe 
            340                 345                 350


Phe Gly Gln Gly Met Asn Ala Gly Phe Glu Asp Cys Leu Val Phe Asp 
        355                 360                 365


Glu Leu Met Asp Lys Phe Ser Asn Asp Leu Ser Leu Cys Leu Pro Val 
    370                 375                 380


Phe Ser Arg Leu Arg Ile Pro Asp Asp His Ala Ile Ser Asp Leu Ser 
385                 390                 395                 400


Met Tyr Asn Tyr Ile Glu Met Arg Ala His Val Asn Ser Ser Trp Phe 
                405                 410                 415


Ile Phe Gln Lys Asn Met Glu Arg Phe Leu His Ala Ile Met Pro Ser 
            420                 425                 430


Thr Phe Ile Pro Leu Tyr Thr Met Val Thr Phe Ser Arg Ile Arg Tyr 
        435                 440                 445


His Glu Ala Val Gln Arg Trp His Trp Gln Lys Lys Val Ile Asn Lys 
    450                 455                 460


Gly Leu Phe Phe Leu Gly Ser Leu Ile Ala Ile Ser Ser Thr Tyr Leu 
465                 470                 475                 480


Leu Ile His Tyr Met Ser Pro Arg Ser Phe Leu Arg Leu Arg Arg Pro 
                485                 490                 495


Trp Asn Trp Ile Ala His Phe Arg Asn Thr Thr Cys Phe Pro Ala Lys 
            500                 505                 510


Ala Val Asp Ser Leu Glu Gln Ile Ser Asn Leu Ile Ser Arg 
        515                 520                 525


<210>  2010
<211>  736
<212>  DNA
<213>  Homo sapiens

<400>  2010
atttcttgac actcctgtct tcttgccacc tcatgatgcg gccaatggta atatttcttg     60

ttttcagaaa ctgacttttt attttgcctc ttgtcttagc acactttctt tctctggaac    120

attctgtctc tcctccttac ttgactaatt cctccttccc tcacaaggct aacagcacga    180

ttttcttgct ctaacccacc ctcagaacca gtttcccatc ctgtgtacta ccatatcctc    240

cctgtttacc tccctcatgg cttctacccg ctcagtgtgc atcatcctca ccaaatagtg    300

aattcctcaa gagcagagac tgggtcttat gtattttctc acctgtgact ggaacagtgt    360

ctgcatgtag tagcttcgtt gtgtggaaga tcttcagaca attcaagtga tcaagatttt    420

aaaatatgaa aagaaactgg ccaaaatgtg ctttttaatg atattcacct tcctggtctg    480

ttggatgcct tatatcgtga tctgcttctt ggtggttaat ggtcatggtc acctggtcac    540

tccaacaata tctattgttt cgtacctctt tgctaaatcg aacactgtat acaatccagt    600

gatttatgtc ttcatgatca gaaagggagt ccacggcctt tgcggggaaa catgttgtat    660

tccggaagtg agctatccag ttccatggtc ttctcaagcg gaggaaagat cgtggtgaca    720

tgtagtgtat aagtag                                                    736


<210>  2011
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  2011

Met Cys Phe Leu Met Ile Phe Thr Phe Leu Val Cys Trp Met Pro Tyr 
1               5                   10                  15


Ile Val Ile Cys Phe Leu Val Val Asn Gly His Gly His Leu Val Thr 
            20                  25                  30


Pro Thr Ile Ser Ile Val Ser Tyr Leu Phe Ala Lys Ser Asn Thr Val 
        35                  40                  45


Tyr Asn Pro Val Ile Tyr Val Phe Met Ile Arg Lys Gly Val His Gly 
    50                  55                  60


Leu Cys Gly Glu Thr Cys Cys Ile Pro Glu Val Ser Tyr Pro Val Pro 
65                  70                  75                  80


Trp Ser Ser Gln Ala Glu Glu Arg Ser Trp 
                85                  90


<210>  2012
<211>  2607
<212>  DNA
<213>  Homo sapiens

<400>  2012
aagctgagcg cctccgcccg ccaggcgcgc cggcgccggg ccatgtactc ggggaaccgc     60

agcggcggcc acggctactg ggacggcggc ggggccgcgg gcgctgaggg gccggcgccg    120

gcggggacac tgagccccgc gcccctcttc agccccggca cctacgagcg cctggcgctg    180

ctgctgggct ccattgggct gctgggcgtc ggcaacaacc tgctggtgct cgtcctctac    240

tacaagttcc agcggctccg cactcccact cacctcctcc tggtcaacat cagcctcagc    300

gacctgctgg tgtccctctt cggggtcacc tttaccttcg tgtcctgcct gaggaacggc    360

tgggtgtggg acaccgtggg ctgcgtgtgg gacgggttta gcggcagcct cttcggttgg    420

atcagccagc ttcaggcagc cactagggaa gccagagcct ccatgggtcc agtgcagcaa    480

ggcactatct gcatgcagac ggagtctcac tctgttgccc aggctggagt gcattggcat    540

gatctcggct gactgcaacc tccacctcat ggattccagc gattctcctg cttcagcctc    600

ccaagtagct gggactacag cttcgttgtg tggaagatct tcagacaatt caagtgatca    660

agattttaaa atatgaaaag aaactggcca aaatgtgctt tttaatgata ttcaccttcc    720

tggtctgttg gatgccttat atcgtgatct gcttcttggt ggttaatggt catggtcacc    780

tggtcactcc aacaatatct attgtttcgt acctctttgc taaatcgaac actgtataca    840

atccagtgat ttatgtcttc atgatcagaa agtttcgaag atcccttttg cagcttctgt    900

gcctccgact gctgaggtgc cagaggcctg ctaaagacct accagcagct ggaagtgaaa    960

tgcagatcag acccattgtg atgtcacaga aagatgggga caggccaaag aaaaaagtga   1020

ctttcaactc ttcttccatc atttttatca tcaccagtga tgaatcactg tcagttgacg   1080

acagcgacaa aaccaatggg tccaaagttg atgtaatcca agttcgtcct ttgtaggaat   1140

gaagaatggc aacgaaagat ggggccttaa attggatgcc acttttggac tttcatcata   1200

agaagtgtct ggaatacccg ttctatgtaa tatcaacaga accttgtggt ccagcaggaa   1260

atccgaattg cccatatgct cttgggcctc aggaagaggt tgaacaaaaa caaattcttt   1320

taattcaacg ggtgctttac ataatgaaaa aaccacttgt ggcacacgat gggcatctaa   1380

catcatcatc ttctaatgtg ttggagattt tcatttcaaa tatatttttt aaattactct   1440

attttccaaa acacgtaatg catttttctc gaaaatacct tactgtaaaa ataactgtcg   1500

cgtacacatg tgtgaagtag ctagaacata ctgaattttt tttgtactgt tggactctat   1560

tcagtgtcat gtcctatatc tgatcaagtt atcaaggaga taattctaga atgaaaaaga   1620

aaatcctctt gttggaaaca aaagacgttt tatatgtgca gtatgacaaa gaggagtttc   1680

agagacaact ttgaatcctt gtcagcctgg agaccagcac cagaggaatc tacaaggcaa   1740

actcccatat atttgcttcc cccaaattgc tgcccctaca gactcaaagc tctttttctt   1800

tgttttgttg tttctctaaa aatttactgt tctttgtcga tgctatataa gccagggagt   1860

tctaagacgc cagctctttg agatttgctc attcccctgt atttcccaca tatatattac   1920

atatacccgc taataaattt atgtttgttt ttctcttgtc aatctgtctt ttgttatagg   1980

ggccccagcc aaggaaccta aagtgggtag aaggaaaaat tattttttct ttccctacaa   2040

actgaacatg gattattaga actcaaggtt ttcattgaca atatagaaaa gaaacactga   2100

atcattttat tttattgccc aatttttatt tcttatatga ctctagtgtt tcatcttcat   2160

aattaatcat gtttgaagga tttctgagtg actcagcagc ctgttaaaga aggatgaacc   2220

aaagaaaaca tttcactaaa tgtgctttta aaaatcaagt gtattgctgg ttctgctgca   2280

gtatgtagtc gaagaataaa ttagtaaatt gcttctgagg gtctgaaatt gaataaagta   2340

atggctttgt atttctataa aagttgtctc cccttgtttc ctttccattc tggcacatgt   2400

agacatttaa tttatgaata aaaccctttc ctgtccttca cttagtatga tattaatagc   2460

ctttttctta tctttagagg gtaactctgg gctggcagcg gtggctcaca actctaatcc   2520

ctgtactttg ggaggctgag gtgggcagat cacatgaggc caggagtttg agactggcct   2580

gggcagcatg gcaagacccg gtctcta                                       2607


<210>  2013
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  2013

Met Tyr Ser Gly Asn Arg Ser Gly Gly His Gly Tyr Trp Asp Gly Gly 
1               5                   10                  15


Gly Ala Ala Gly Ala Glu Gly Pro Ala Pro Ala Gly Thr Leu Ser Pro 
            20                  25                  30


Ala Pro Leu Phe Ser Pro Gly Thr Tyr Glu Arg Leu Ala Leu Leu Leu 
        35                  40                  45


Gly Ser Ile Gly Leu Leu Gly Val Gly Asn Asn Leu Leu Val Leu Val 
    50                  55                  60


Leu Tyr Tyr Lys Phe Gln Arg Leu Arg Thr Pro Thr His Leu Leu Leu 
65                  70                  75                  80


Val Asn Ile Ser Leu Ser Asp Leu Leu Val Ser Leu Phe Gly Val Thr 
                85                  90                  95


Phe Thr Phe Val Ser Cys Leu Arg Asn Gly Trp Val Trp Asp Thr Val 
            100                 105                 110


Gly Cys Val Trp Asp Gly Phe Ser Gly Ser Leu Phe Gly Trp Ile Ser 
        115                 120                 125


Gln Leu Gln Ala Ala Thr Arg Glu Ala Arg Ala Ser Met Gly Pro Val 
    130                 135                 140


Gln Gln Gly Thr Ile Cys Met Gln Thr Glu Ser His Ser Val Ala Gln 
145                 150                 155                 160


Ala Gly Val His Trp His Asp Leu Gly 
                165


<210>  2014
<211>  2825
<212>  DNA
<213>  Homo sapiens

<400>  2014
gggcccggcg cgcggtagcg cgggcccctc agtgcacaat ggctagagca ggcggcggag     60

ccccaacccc acccagtgcg gagcgcgccg cgagccccgc cgcaagctga gcgcctccgc    120

ccgccaggcg cgccggcgcc gggccatgta ctcggggaac cgcagcggcg gccacggcta    180

ctgggacggc ggcggggccg cgggcgctga ggggccggcg ccggcgggga cactgagccc    240

cgcgcccctc ttcagccccg gcacctacga gcgcctggcg ctgctgctgg gctccattgg    300

gctgctgggc gtcggcaaca acctgctggt gctcgtcctc tactacaagt tccagcggct    360

ccgcactccc actcacctcc tcctggtcaa catcagcctc agcgacctgc tggtgtccct    420

cttcggggtc acctttacct tcgtgtcctg cctgaggaac ggctgggtgt gggacaccgt    480

gggctgcgtg tgggacgggt ttagcggcag cctcttcggg attgtttcca ttgccaccct    540

aaccgtgctg gcctatgaac gttacattcg cgtggtccat gccagagtga tcaatttttc    600

ctgggcctgg agggccatta cctacatctg gctctactca ctggcgtggg caggagcacc    660

tctcctggga tggaacaggt acatcctgga cgtacacgga ctaggctgca ctgtggactg    720

gaaatccaag gatgccaacg attcctcctt tgtgcttttc ttatttcttg gctgcctggt    780

ggtgcccctg ggtgtcatag cccattgcta tggccatatt ctatattcca ttcgaatgct    840

tcgttgtgtg gaagatcttc agacaattca agtgatcaag attttaaaat atgaaaagaa    900

actggccaaa atgtgctttt taatgatatt caccttcctg gtctgttgga tgccttatat    960

cgtgatctgc ttcttggtgg ttaatggtca tggtcacctg gtcactccaa caatatctat   1020

tgtttcgtac ctctttgcta aatcgaacac tgtatacaat ccagtgattt atgtcttcat   1080

gatcagaaag tttcgaagat cccttttgca gcttctgtgc ctccgactgc tgaggtgcca   1140

gaggcctgct aaagacctac cagcagctgg aagtgaaatg cagatcagac ccattgtgat   1200

gtcacagaaa gatggggaca ggccaaagaa aaaagtgact ttcaactctt cttccatcat   1260

ttttatcatc accagtgatg aatcactgtc agttgacgac agcgacaaaa ccaatgggtc   1320

caaagttgat gtaatccaag ttcgtccttt gtaggaatga agaatggcaa cgaaagatgg   1380

ggccttaaat tggatgccac ttttggactt tcatcataag aagtgtctgg aatacccgtt   1440

ctatgtaata tcaacagaac cttgtggtcc agcaggaaat ccgaattgcc catatgctct   1500

tgggcctcag gaagaggttg aacaaaaaca aattctttta attcaacggg tgctttacat   1560

aatgaaaaaa ccacttgtgg cacacgatgg gcatctaaca tcatcatctt ctaatgtgtt   1620

ggagattttc atttcaaata tattttttaa attactctat tttccaaaac acgtaatgca   1680

tttttctcga aaatacctta ctgtaaaaat aactgtcgcg tacacatgtg tgaagtagct   1740

agaacatact gaattttttt tgtactgttg gactctattc agtgtcatgt cctatatctg   1800

atcaagttat caaggagata attctagaat gaaaaagaaa atcctcttgt tggaaacaaa   1860

agacgtttta tatgtgcagt atgacaaaga ggagtttcag agacaacttt gaatccttgt   1920

cagcctggag accagcacca gaggaatcta caaggcaaac tcccatatat ttgcttcccc   1980

caaattgctg cccctacaga ctcaaagctc tttttctttg ttttgttgtt tctctaaaaa   2040

tttactgttc tttgtcgatg ctatataagc cagggagttc taagacgcca gctctttgag   2100

atttgctcat tcccctgtat ttcccacata tatattacat atacccgcta ataaatttat   2160

gtttgttttt ctcttgtcaa tctgtctttt gttatagggg ccccagccaa ggaacctaaa   2220

gtgggtagaa ggaaaaatta ttttttcttt ccctacaaac tgaacatgga ttattagaac   2280

tcaaggtttt cattgacaat atagaaaaga aacactgaat cattttattt tattgcccaa   2340

tttttatttc ttatatgact ctagtgtttc atcttcataa ttaatcatgt ttgaaggatt   2400

tctgagtgac tcagcagcct gttaaagaag gatgaaccaa agaaaacatt tcactaaatg   2460

tgcttttaaa aatcaagtgt attgctggtt ctgctgcagt atgtagtcga agaataaatt   2520

agtaaattgc ttctgagggt ctgaaattga ataaagtaat ggctttgtat ttctataaaa   2580

gttgtctccc cttgtttcct ttccattctg gcacatgtag acatttaatt tatgaataaa   2640

accctttcct gtccttcact tagtatgata ttaatagcct ttttcttatc tttagagggt   2700

aactctgggc tggcagcggt ggctcacaac tctaatccct gtactttggg aggctgaggt   2760

gggcagatca catgaggcca ggagtttgag actggcctgg gcagcatggc aagacccggt   2820

ctcta                                                               2825


<210>  2015
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  2015

Met Tyr Ser Gly Asn Arg Ser Gly Gly His Gly Tyr Trp Asp Gly Gly 
1               5                   10                  15


Gly Ala Ala Gly Ala Glu Gly Pro Ala Pro Ala Gly Thr Leu Ser Pro 
            20                  25                  30


Ala Pro Leu Phe Ser Pro Gly Thr Tyr Glu Arg Leu Ala Leu Leu Leu 
        35                  40                  45


Gly Ser Ile Gly Leu Leu Gly Val Gly Asn Asn Leu Leu Val Leu Val 
    50                  55                  60


Leu Tyr Tyr Lys Phe Gln Arg Leu Arg Thr Pro Thr His Leu Leu Leu 
65                  70                  75                  80


Val Asn Ile Ser Leu Ser Asp Leu Leu Val Ser Leu Phe Gly Val Thr 
                85                  90                  95


Phe Thr Phe Val Ser Cys Leu Arg Asn Gly Trp Val Trp Asp Thr Val 
            100                 105                 110


Gly Cys Val Trp Asp Gly Phe Ser Gly Ser Leu Phe Gly Ile Val Ser 
        115                 120                 125


Ile Ala Thr Leu Thr Val Leu Ala Tyr Glu Arg Tyr Ile Arg Val Val 
    130                 135                 140


His Ala Arg Val Ile Asn Phe Ser Trp Ala Trp Arg Ala Ile Thr Tyr 
145                 150                 155                 160


Ile Trp Leu Tyr Ser Leu Ala Trp Ala Gly Ala Pro Leu Leu Gly Trp 
                165                 170                 175


Asn Arg Tyr Ile Leu Asp Val His Gly Leu Gly Cys Thr Val Asp Trp 
            180                 185                 190


Lys Ser Lys Asp Ala Asn Asp Ser Ser Phe Val Leu Phe Leu Phe Leu 
        195                 200                 205


Gly Cys Leu Val Val Pro Leu Gly Val Ile Ala His Cys Tyr Gly His 
    210                 215                 220


Ile Leu Tyr Ser Ile Arg Met Leu Arg Cys Val Glu Asp Leu Gln Thr 
225                 230                 235                 240


Ile Gln Val Ile Lys Ile Leu Lys Tyr Glu Lys Lys Leu Ala Lys Met 
                245                 250                 255


Cys Phe Leu Met Ile Phe Thr Phe Leu Val Cys Trp Met Pro Tyr Ile 
            260                 265                 270


Val Ile Cys Phe Leu Val Val Asn Gly His Gly His Leu Val Thr Pro 
        275                 280                 285


Thr Ile Ser Ile Val Ser Tyr Leu Phe Ala Lys Ser Asn Thr Val Tyr 
    290                 295                 300


Asn Pro Val Ile Tyr Val Phe Met Ile Arg Lys Phe Arg Arg Ser Leu 
305                 310                 315                 320


Leu Gln Leu Leu Cys Leu Arg Leu Leu Arg Cys Gln Arg Pro Ala Lys 
                325                 330                 335


Asp Leu Pro Ala Ala Gly Ser Glu Met Gln Ile Arg Pro Ile Val Met 
            340                 345                 350


Ser Gln Lys Asp Gly Asp Arg Pro Lys Lys Lys Val Thr Phe Asn Ser 
        355                 360                 365


Ser Ser Ile Ile Phe Ile Ile Thr Ser Asp Glu Ser Leu Ser Val Asp 
    370                 375                 380


Asp Ser Asp Lys Thr Asn Gly Ser Lys Val Asp Val Ile Gln Val Arg 
385                 390                 395                 400


Pro Leu 



<210>  2016
<211>  2665
<212>  DNA
<213>  Homo sapiens

<400>  2016
gggcccggcg cgcggtagcg cgggcccctc agtgcacaat ggctagagca ggcggcggag     60

ccccaacccc acccagtgcg gagcgcgccg cgagccccgc cgcaagctga gcgcctccgc    120

ccgccaggcg cgccggcgcc gggccatgta ctcggggaac cgcagcggcg gccacggcta    180

ctgggacggc ggcggggccg cgggcgctga ggggccggcg ccggcgggga cactgagccc    240

cgcgcccctc ttcagccccg gcacctacga gcgcctggcg ctgctgctgg gctccattgg    300

gctgctgggc gtcggcaaca acctgctggt gctcgtcctc tactacaagt tccagcggct    360

ccgcactccc actcacctcc tcctggtcaa catcagcctc agcgacctgc tggtgtccct    420

cttcggggtc acctttacct tcgtgtcctg cctgaggaac ggctgggtgt gggacaccgt    480

gggctgcgtg tgggacgggt ttagcggcag cctcttcggg attgtttcca ttgccaccct    540

aaccgtgctg gcctatgaac gttacattcg cgtggtccat gccagagtga tcaatttttc    600

ctgggcctgg agggccatta cctacatctg gctctactca ctggcgtggg caggagcacc    660

tctcctggga tggaacagct tcgttgtgtg gaagatcttc agacaattca agtgatcaag    720

attttaaaat atgaaaagaa actggccaaa atgtgctttt taatgatatt caccttcctg    780

gtctgttgga tgccttatat cgtgatctgc ttcttggtgg ttaatggtca tggtcacctg    840

gtcactccaa caatatctat tgtttcgtac ctctttgcta aatcgaacac tgtatacaat    900

ccagtgattt atgtcttcat gatcagaaag tttcgaagat cccttttgca gcttctgtgc    960

ctccgactgc tgaggtgcca gaggcctgct aaagacctac cagcagctgg aagtgaaatg   1020

cagatcagac ccattgtgat gtcacagaaa gatggggaca ggccaaagaa aaaagtgact   1080

ttcaactctt cttccatcat ttttatcatc accagtgatg aatcactgtc agttgacgac   1140

agcgacaaaa ccaatgggtc caaagttgat gtaatccaag ttcgtccttt gtaggaatga   1200

agaatggcaa cgaaagatgg ggccttaaat tggatgccac ttttggactt tcatcataag   1260

aagtgtctgg aatacccgtt ctatgtaata tcaacagaac cttgtggtcc agcaggaaat   1320

ccgaattgcc catatgctct tgggcctcag gaagaggttg aacaaaaaca aattctttta   1380

attcaacggg tgctttacat aatgaaaaaa ccacttgtgg cacacgatgg gcatctaaca   1440

tcatcatctt ctaatgtgtt ggagattttc atttcaaata tattttttaa attactctat   1500

tttccaaaac acgtaatgca tttttctcga aaatacctta ctgtaaaaat aactgtcgcg   1560

tacacatgtg tgaagtagct agaacatact gaattttttt tgtactgttg gactctattc   1620

agtgtcatgt cctatatctg atcaagttat caaggagata attctagaat gaaaaagaaa   1680

atcctcttgt tggaaacaaa agacgtttta tatgtgcagt atgacaaaga ggagtttcag   1740

agacaacttt gaatccttgt cagcctggag accagcacca gaggaatcta caaggcaaac   1800

tcccatatat ttgcttcccc caaattgctg cccctacaga ctcaaagctc tttttctttg   1860

ttttgttgtt tctctaaaaa tttactgttc tttgtcgatg ctatataagc cagggagttc   1920

taagacgcca gctctttgag atttgctcat tcccctgtat ttcccacata tatattacat   1980

atacccgcta ataaatttat gtttgttttt ctcttgtcaa tctgtctttt gttatagggg   2040

ccccagccaa ggaacctaaa gtgggtagaa ggaaaaatta ttttttcttt ccctacaaac   2100

tgaacatgga ttattagaac tcaaggtttt cattgacaat atagaaaaga aacactgaat   2160

cattttattt tattgcccaa tttttatttc ttatatgact ctagtgtttc atcttcataa   2220

ttaatcatgt ttgaaggatt tctgagtgac tcagcagcct gttaaagaag gatgaaccaa   2280

agaaaacatt tcactaaatg tgcttttaaa aatcaagtgt attgctggtt ctgctgcagt   2340

atgtagtcga agaataaatt agtaaattgc ttctgagggt ctgaaattga ataaagtaat   2400

ggctttgtat ttctataaaa gttgtctccc cttgtttcct ttccattctg gcacatgtag   2460

acatttaatt tatgaataaa accctttcct gtccttcact tagtatgata ttaatagcct   2520

ttttcttatc tttagagggt aactctgggc tggcagcggt ggctcacaac tctaatccct   2580

gtactttggg aggctgaggt gggcagatca catgaggcca ggagtttgag actggcctgg   2640

gcagcatggc aagacccggt ctcta                                         2665


<210>  2017
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  2017

Met Tyr Ser Gly Asn Arg Ser Gly Gly His Gly Tyr Trp Asp Gly Gly 
1               5                   10                  15


Gly Ala Ala Gly Ala Glu Gly Pro Ala Pro Ala Gly Thr Leu Ser Pro 
            20                  25                  30


Ala Pro Leu Phe Ser Pro Gly Thr Tyr Glu Arg Leu Ala Leu Leu Leu 
        35                  40                  45


Gly Ser Ile Gly Leu Leu Gly Val Gly Asn Asn Leu Leu Val Leu Val 
    50                  55                  60


Leu Tyr Tyr Lys Phe Gln Arg Leu Arg Thr Pro Thr His Leu Leu Leu 
65                  70                  75                  80


Val Asn Ile Ser Leu Ser Asp Leu Leu Val Ser Leu Phe Gly Val Thr 
                85                  90                  95


Phe Thr Phe Val Ser Cys Leu Arg Asn Gly Trp Val Trp Asp Thr Val 
            100                 105                 110


Gly Cys Val Trp Asp Gly Phe Ser Gly Ser Leu Phe Gly Ile Val Ser 
        115                 120                 125


Ile Ala Thr Leu Thr Val Leu Ala Tyr Glu Arg Tyr Ile Arg Val Val 
    130                 135                 140


His Ala Arg Val Ile Asn Phe Ser Trp Ala Trp Arg Ala Ile Thr Tyr 
145                 150                 155                 160


Ile Trp Leu Tyr Ser Leu Ala Trp Ala Gly Ala Pro Leu Leu Gly Trp 
                165                 170                 175


Asn Ser Phe Val Val Trp Lys Ile Phe Arg Gln Phe Lys 
            180                 185


<210>  2018
<211>  2505
<212>  DNA
<213>  Homo sapiens

<400>  2018
gggcccggcg cgcggtagcg cgggcccctc agtgcacaat ggctagagca ggcggcggag     60

ccccaacccc acccagtgcg gagcgcgccg cgagccccgc cgcaagctga gcgcctccgc    120

ccgccaggcg cgccggcgcc gggccatgta ctcggggaac cgcagcggcg gccacggcta    180

ctgggacggc ggcggggccg cgggcgctga ggggccggcg ccggcgggga cactgagccc    240

cgcgcccctc ttcagccccg gcacctacga gcgcctggcg ctgctgctgg gctccattgg    300

gctgctgggc gtcggcaaca acctgctggt gctcgtcctc tactacaagt tccagcggct    360

ccgcactccc actcacctcc tcctggtcaa catcagcctc agcgacctgc tggtgtccct    420

cttcggggtc acctttacct tcgtgtcctg cctgaggaac ggctgggtgt gggacaccgt    480

gggctgcgtg tgggacgggt ttagcggcag cctcttcgct tcgttgtgtg gaagatcttc    540

agacaattca agtgatcaag attttaaaat atgaaaagaa actggccaaa atgtgctttt    600

taatgatatt caccttcctg gtctgttgga tgccttatat cgtgatctgc ttcttggtgg    660

ttaatggtca tggtcacctg gtcactccaa caatatctat tgtttcgtac ctctttgcta    720

aatcgaacac tgtatacaat ccagtgattt atgtcttcat gatcagaaag tttcgaagat    780

cccttttgca gcttctgtgc ctccgactgc tgaggtgcca gaggcctgct aaagacctac    840

cagcagctgg aagtgaaatg cagatcagac ccattgtgat gtcacagaaa gatggggaca    900

ggccaaagaa aaaagtgact ttcaactctt cttccatcat ttttatcatc accagtgatg    960

aatcactgtc agttgacgac agcgacaaaa ccaatgggtc caaagttgat gtaatccaag   1020

ttcgtccttt gtaggaatga agaatggcaa cgaaagatgg ggccttaaat tggatgccac   1080

ttttggactt tcatcataag aagtgtctgg aatacccgtt ctatgtaata tcaacagaac   1140

cttgtggtcc agcaggaaat ccgaattgcc catatgctct tgggcctcag gaagaggttg   1200

aacaaaaaca aattctttta attcaacggg tgctttacat aatgaaaaaa ccacttgtgg   1260

cacacgatgg gcatctaaca tcatcatctt ctaatgtgtt ggagattttc atttcaaata   1320

tattttttaa attactctat tttccaaaac acgtaatgca tttttctcga aaatacctta   1380

ctgtaaaaat aactgtcgcg tacacatgtg tgaagtagct agaacatact gaattttttt   1440

tgtactgttg gactctattc agtgtcatgt cctatatctg atcaagttat caaggagata   1500

attctagaat gaaaaagaaa atcctcttgt tggaaacaaa agacgtttta tatgtgcagt   1560

atgacaaaga ggagtttcag agacaacttt gaatccttgt cagcctggag accagcacca   1620

gaggaatcta caaggcaaac tcccatatat ttgcttcccc caaattgctg cccctacaga   1680

ctcaaagctc tttttctttg ttttgttgtt tctctaaaaa tttactgttc tttgtcgatg   1740

ctatataagc cagggagttc taagacgcca gctctttgag atttgctcat tcccctgtat   1800

ttcccacata tatattacat atacccgcta ataaatttat gtttgttttt ctcttgtcaa   1860

tctgtctttt gttatagggg ccccagccaa ggaacctaaa gtgggtagaa ggaaaaatta   1920

ttttttcttt ccctacaaac tgaacatgga ttattagaac tcaaggtttt cattgacaat   1980

atagaaaaga aacactgaat cattttattt tattgcccaa tttttatttc ttatatgact   2040

ctagtgtttc atcttcataa ttaatcatgt ttgaaggatt tctgagtgac tcagcagcct   2100

gttaaagaag gatgaaccaa agaaaacatt tcactaaatg tgcttttaaa aatcaagtgt   2160

attgctggtt ctgctgcagt atgtagtcga agaataaatt agtaaattgc ttctgagggt   2220

ctgaaattga ataaagtaat ggctttgtat ttctataaaa gttgtctccc cttgtttcct   2280

ttccattctg gcacatgtag acatttaatt tatgaataaa accctttcct gtccttcact   2340

tagtatgata ttaatagcct ttttcttatc tttagagggt aactctgggc tggcagcggt   2400

ggctcacaac tctaatccct gtactttggg aggctgaggt gggcagatca catgaggcca   2460

ggagtttgag actggcctgg gcagcatggc aagacccggt ctcta                   2505


<210>  2019
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  2019

Met Cys Phe Leu Met Ile Phe Thr Phe Leu Val Cys Trp Met Pro Tyr 
1               5                   10                  15


Ile Val Ile Cys Phe Leu Val Val Asn Gly His Gly His Leu Val Thr 
            20                  25                  30


Pro Thr Ile Ser Ile Val Ser Tyr Leu Phe Ala Lys Ser Asn Thr Val 
        35                  40                  45


Tyr Asn Pro Val Ile Tyr Val Phe Met Ile Arg Lys Phe Arg Arg Ser 
    50                  55                  60


Leu Leu Gln Leu Leu Cys Leu Arg Leu Leu Arg Cys Gln Arg Pro Ala 
65                  70                  75                  80


Lys Asp Leu Pro Ala Ala Gly Ser Glu Met Gln Ile Arg Pro Ile Val 
                85                  90                  95


Met Ser Gln Lys Asp Gly Asp Arg Pro Lys Lys Lys Val Thr Phe Asn 
            100                 105                 110


Ser Ser Ser Ile Ile Phe Ile Ile Thr Ser Asp Glu Ser Leu Ser Val 
        115                 120                 125


Asp Asp Ser Asp Lys Thr Asn Gly Ser Lys Val Asp Val Ile Gln Val 
    130                 135                 140


Arg Pro Leu 
145


<210>  2020
<211>  2061
<212>  DNA
<213>  Homo sapiens

<400>  2020
gaagagttca aaaaggcttt tctaacccgg gactgacttc taggtggaaa aaatacatcg     60

ctgtaagaaa accgcttcgt tgtgtggaag atcttcagac aattcaagtg atcaagattt    120

taaaatatga aaagaaactg gccaaaatgt gctttttaat gatattcacc ttcctggtct    180

gttggatgcc ttatatcgtg atctgcttct tggtggttaa tggtcatggt cacctggtca    240

ctccaacaat atctattgtt tcgtacctct ttgctaaatc gaacactgta tacaatccag    300

tgatttatgt cttcatgatc agaaagtttc gaagatccct tttgcagctt ctgtgcctcc    360

gactgctgag gtgccagagg cctgctaaag acctaccagc agctggaagt gaaatgcaga    420

tcagacccat tgtgatgtca cagaaagatg gggacaggcc aaagaaaaaa gtgactttca    480

actcttcttc catcattttt atcatcacca gtgatgaatc actgtcagtt gacgacagcg    540

acaaaaccaa tgggtccaaa gttgatgtaa tccaagttcg tcctttgtag gaatgaagaa    600

tggcaacgaa agatggggcc ttaaattgga tgccactttt ggactttcat cataagaagt    660

gtctggaata cccgttctat gtaatatcaa cagaaccttg tggtccagca ggaaatccga    720

attgcccata tgctcttggg cctcaggaag aggttgaaca aaaacaaatt cttttaattc    780

aacgggtgct ttacataatg aaaaaaccac ttgtggcaca cgatgggcat ctaacatcat    840

catcttctaa tgtgttggag attttcattt caaatatatt ttttaaatta ctctattttc    900

caaaacacgt aatgcatttt tctcgaaaat accttactgt aaaaataact gtcgcgtaca    960

catgtgtgaa gtagctagaa catactgaat tttttttgta ctgttggact ctattcagtg   1020

tcatgtccta tatctgatca agttatcaag gagataattc tagaatgaaa aagaaaatcc   1080

tcttgttgga aacaaaagac gttttatatg tgcagtatga caaagaggag tttcagagac   1140

aactttgaat ccttgtcagc ctggagacca gcaccagagg aatctacaag gcaaactccc   1200

atatatttgc ttcccccaaa ttgctgcccc tacagactca aagctctttt tctttgtttt   1260

gttgtttctc taaaaattta ctgttctttg tcgatgctat ataagccagg gagttctaag   1320

acgccagctc tttgagattt gctcattccc ctgtatttcc cacatatata ttacatatac   1380

ccgctaataa atttatgttt gtttttctct tgtcaatctg tcttttgtta taggggcccc   1440

agccaaggaa cctaaagtgg gtagaaggaa aaattatttt ttctttccct acaaactgaa   1500

catggattat tagaactcaa ggttttcatt gacaatatag aaaagaaaca ctgaatcatt   1560

ttattttatt gcccaatttt tatttcttat atgactctag tgtttcatct tcataattaa   1620

tcatgtttga aggatttctg agtgactcag cagcctgtta aagaaggatg aaccaaagaa   1680

aacatttcac taaatgtgct tttaaaaatc aagtgtattg ctggttctgc tgcagtatgt   1740

agtcgaagaa taaattagta aattgcttct gagggtctga aattgaataa agtaatggct   1800

ttgtatttct ataaaagttg tctccccttg tttcctttcc attctggcac atgtagacat   1860

ttaatttatg aataaaaccc tttcctgtcc ttcacttagt atgatattaa tagccttttt   1920

cttatcttta gagggtaact ctgggctggc agcggtggct cacaactcta atccctgtac   1980

tttgggaggc tgaggtgggc agatcacatg aggccaggag tttgagactg gcctgggcag   2040

catggcaaga cccggtctct a                                             2061


<210>  2021
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  2021

Met Cys Phe Leu Met Ile Phe Thr Phe Leu Val Cys Trp Met Pro Tyr 
1               5                   10                  15


Ile Val Ile Cys Phe Leu Val Val Asn Gly His Gly His Leu Val Thr 
            20                  25                  30


Pro Thr Ile Ser Ile Val Ser Tyr Leu Phe Ala Lys Ser Asn Thr Val 
        35                  40                  45


Tyr Asn Pro Val Ile Tyr Val Phe Met Ile Arg Lys Phe Arg Arg Ser 
    50                  55                  60


Leu Leu Gln Leu Leu Cys Leu Arg Leu Leu Arg Cys Gln Arg Pro Ala 
65                  70                  75                  80


Lys Asp Leu Pro Ala Ala Gly Ser Glu Met Gln Ile Arg Pro Ile Val 
                85                  90                  95


Met Ser Gln Lys Asp Gly Asp Arg Pro Lys Lys Lys Val Thr Phe Asn 
            100                 105                 110


Ser Ser Ser Ile Ile Phe Ile Ile Thr Ser Asp Glu Ser Leu Ser Val 
        115                 120                 125


Asp Asp Ser Asp Lys Thr Asn Gly Ser Lys Val Asp Val Ile Gln Val 
    130                 135                 140


Arg Pro Leu 
145


<210>  2022
<211>  2358
<212>  DNA
<213>  Homo sapiens

<400>  2022
aagctgagcg cctccgcccg ccaggcgcgc cggcgccggg ccatgtactc ggggaaccgc     60

agcggcggcc acggctactg ggacggcggc ggggccgcgg gcgctgaggg gccggcgccg    120

gcggggacac tgagccccgc gcccctcttc agccccggca cctacgagcg cctggcgctg    180

ctgctgggct ccattgggct gctgggcgtc ggcaacaacc tgctggtgct cgtcctctac    240

tacaagttcc agcggctccg cactcccact cacctcctcc tggtcaacat cagcctcagc    300

gacctgctgg tgtccctctt cggggtcacc tttaccttcg tgtcctgcct gaggaacggc    360

tgggtgtggg acaccgtggg ctgcgtgtgg gacgggttta gcggcagcct cttcggttgg    420

atcagccagc ttcaggcagc cactagggaa gccagagcct ccatgggtcc agtgcagcaa    480

ggcactatct gcatgcagac ggagtctcac tctgttgccc aggctggagt gcattggcat    540

gatctcggct gactgcaacc tccacctcat ggattccagc gattctcctg cttcagcctc    600

ccaagtagct gggactacag cttcgttgtg tggaagatct tcagacaatt caagtgatca    660

agattttaaa atatgaaaag aaactggcca aaatgtgctt tttaatgata ttcaccttcc    720

tggtctgttg gatgccttat atcgtgatct gcttcttggt ggttaatggt catggtcacc    780

tggtcactcc aacaatatct attgtttcgt acctctttgc taaatcgaac actgtataca    840

atccagtgat ttatgtcttc atgatcagaa agtttcgaag atcccttttg cagcttctgt    900

gcctccgact gctgaggtgc cagaggcctg ctaaagacct accagcagct ggaagtgaaa    960

tgcagatcag acccattgtg atgtcacaga aagatgggga caggccaaag aaaaaagtga   1020

ctttcaactc ttcttccatc atttttatca tcaccagtga tgaatcactg tcagttgacg   1080

acagcgacaa aaccaatggg tccaaagttg atgtaatcca agttcgtcct ttgtaggaat   1140

gaagaatggc aacgaaagat ggggccttaa attggatgcc acttttggac tttcatcata   1200

agaagtgtct ggaatacccg ttctatgtaa tatcaacaga accttgtggt ccagcaggaa   1260

atccgaattg cccatatgct cttgggcctc aggaagaggt tgaacaaaaa caaattcttt   1320

taattcaacg ggtgctttac ataatgaaaa aaccacttgt ggcacacgat gggcatctaa   1380

catcatcatc ttctaatgtg ttggagattt tcatttcaaa tatatttttt aaattactct   1440

attttccaaa acacgtaatg catttttctc gaaaatacct tactgtaaaa ataactgtcg   1500

cgtacacatg tgtgaagtag ctagaacata ctgaattttt tttgtactgt tggactctat   1560

tcagtgtcat gtcctatatc tgatcaagtt atcaaggaga taattctaga atgaaaaaga   1620

aaatcctctt gttggaaaca aaagacgttt tatatgtgca gtatgacaaa gaggagtttc   1680

agagacaact ttgaatcctt gtcagcctgg agaccagcac cagaggaatc tacaaggcaa   1740

actcccatat atttgcttcc cccaaattgc tgcccctaca gactcaaagc tctttttctt   1800

tgttttgttg tttctctaaa aatttactgt tctttgtcga tgctatataa gccagggagt   1860

tctaagacgc cagctctttg agatttgctc attcccctgt atttcccaca tatatattac   1920

atatacccgc taataaattt atgtttgttt ttctcttgtc aatctgtctt ttgttatagg   1980

ggccccagcc aaggaaccta aagtgggtag aaggaaaaat tattttttct ttccctacaa   2040

actgaacatg gattattaga actcaaggtt ttcattgaca atatagaaaa gaaacactga   2100

atcattttat tttattgccc aatttttatt tcttatatga ctctagtgtt tcatcttcat   2160

aattaatcat gtttgaagga tttctgagtg actcagcagc ctgttaaaga aggatgaacc   2220

aaagaaaaca tttcactaaa tgtgctttta aaaatcaagt gtattgctgg ttctgctgca   2280

gtatgtagtc gaagaataaa ttagtaaatt gcttctgagg gtctgaaatt gaataaagta   2340

atggctttgt atttctat                                                 2358


<210>  2023
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  2023

Met Tyr Ser Gly Asn Arg Ser Gly Gly His Gly Tyr Trp Asp Gly Gly 
1               5                   10                  15


Gly Ala Ala Gly Ala Glu Gly Pro Ala Pro Ala Gly Thr Leu Ser Pro 
            20                  25                  30


Ala Pro Leu Phe Ser Pro Gly Thr Tyr Glu Arg Leu Ala Leu Leu Leu 
        35                  40                  45


Gly Ser Ile Gly Leu Leu Gly Val Gly Asn Asn Leu Leu Val Leu Val 
    50                  55                  60


Leu Tyr Tyr Lys Phe Gln Arg Leu Arg Thr Pro Thr His Leu Leu Leu 
65                  70                  75                  80


Val Asn Ile Ser Leu Ser Asp Leu Leu Val Ser Leu Phe Gly Val Thr 
                85                  90                  95


Phe Thr Phe Val Ser Cys Leu Arg Asn Gly Trp Val Trp Asp Thr Val 
            100                 105                 110


Gly Cys Val Trp Asp Gly Phe Ser Gly Ser Leu Phe Gly Trp Ile Ser 
        115                 120                 125


Gln Leu Gln Ala Ala Thr Arg Glu Ala Arg Ala Ser Met Gly Pro Val 
    130                 135                 140


Gln Gln Gly Thr Ile Cys Met Gln Thr Glu Ser His Ser Val Ala Gln 
145                 150                 155                 160


Ala Gly Val His Trp His Asp Leu Gly 
                165


<210>  2024
<211>  2212
<212>  DNA
<213>  Homo sapiens

<400>  2024
agagcaggcg gcggagcccc aaccccaccc agtgcggagc gcgccgcgag ccccgccgca     60

agctgagcgc ctccgcccgc caggcgcgcc ggcgccgggc catgtactcg gggaaccgca    120

gcggcggcca cggctactgg gacggcggcg gggccgcggg cgctgagggg ccggcgccgg    180

cggggacact gagccccgcg cccctcttca gccccggcac ctacgagcgc ctggcgctgc    240

tgctgggctc cattgggctg ctgggcgtcg gcaacaacct gctggtgctc gtcctctact    300

acaagttcca gcggctccgc actcccactc acctcctcct ggtcaacatc agcctcagcg    360

acctgctggt gtccctcttc ggggtcacct ttaccttcgt gtcctgcctg aggaacggct    420

gggtgtggga caccgtgggc tgcgtgtggg acgggtttag cggcagcctc ttcgcttcgt    480

tgtgtggaag atcttcagac aattcaagtg atcaagattt taaaatatga aaagaaactg    540

gccaaaatgt gctttttaat gatattcacc ttcctggtct gttggatgcc ttatatcgtg    600

atctgcttct tggtggttaa tggtcatggt cacctggtca ctccaacaat atctattgtt    660

tcgtacctct ttgctaaatc gaacactgta tacaatccag tgatttatgt cttcatgatc    720

agaaagtttc gaagatccct tttgcagctt ctgtgcctcc gactgctgag gtgccagagg    780

cctgctaaag acctaccagc agctggaagt gaaatgcaga tcagacccat tgtgatgtca    840

cagaaagatg gggacaggcc aaagaaaaaa gtgactttca actcttcttc catcattttt    900

atcatcacca gtgatgaatc actgtcagtt gacgacagcg acaaaaccaa tgggtccaaa    960

gttgatgtaa tccaagttcg tcctttgtag gaatgaagaa tggcaacgaa agatggggcc   1020

ttaaattgga tgccactttt ggactttcat cataagaagt gtctggaata cccgttctat   1080

gtaatatcaa cagaaccttg tggtccagca ggaaatccga attgcccata tgctcttggg   1140

cctcaggaag aggttgaaca aaaacaaatt cttttaattc aacgggtgct ttacataatg   1200

aaaaaaccac ttgtggcaca cgatgggcat ctaacatcat catcttctaa tgtgttggag   1260

attttcattt caaatatatt ttttaaatta ctctattttc caaaacacgt aatgcatttt   1320

tctcgaaaat accttactgt aaaaataact gtcgcgtaca catgtgtgaa gtagctagaa   1380

catactgaat tttttttgta ctgttggact ctattcagtg tcatgtccta tatctgatca   1440

agttatcaag gagataattc tagaatgaaa aagaaaatcc tcttgttgga aacaaaagac   1500

gttttatatg tgcagtatga caaagaggag tttcagagac aactttgaat ccttgtcagc   1560

ctggagacca gcaccagagg aatctacaag gcaaactccc atatatttgc ttcccccaaa   1620

ttgctgcccc tacagactca aagctctttt tctttgtttt gttgtttctc taaaaattta   1680

ctgttctttg tcgatgctat ataagccagg gagttctaag acgccagctc tttgagattt   1740

gctcattccc ctgtatttcc cacatatata ttacatatac ccgctaataa atttatgttt   1800

gtttttctct tgtcaatctg tcttttgtta taggggcccc agccaaggaa cctaaagtgg   1860

gtagaaggaa aaattatttt ttctttccct acaaactgaa catggattat tagaactcaa   1920

ggttttcatt gacaatatag aaaagaaaca ctgaatcatt ttattttatt gcccaatttt   1980

tatttcttat atgactctag tgtttcatct tcataattaa tcatgtttga aggatttctg   2040

agtgactcag cagcctgtta aagaaggatg aaccaaagaa aacatttcac taaatgtgct   2100

tttaaaaatc aagtgtattg ctggttctgc tgcagtatgt agtcgaagaa taaattagta   2160

aattgcttct gagggtctga aattgaataa agtaatggct ttgtatttct at           2212


<210>  2025
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  2025

Met Cys Phe Leu Met Ile Phe Thr Phe Leu Val Cys Trp Met Pro Tyr 
1               5                   10                  15


Ile Val Ile Cys Phe Leu Val Val Asn Gly His Gly His Leu Val Thr 
            20                  25                  30


Pro Thr Ile Ser Ile Val Ser Tyr Leu Phe Ala Lys Ser Asn Thr Val 
        35                  40                  45


Tyr Asn Pro Val Ile Tyr Val Phe Met Ile Arg Lys Phe Arg Arg Ser 
    50                  55                  60


Leu Leu Gln Leu Leu Cys Leu Arg Leu Leu Arg Cys Gln Arg Pro Ala 
65                  70                  75                  80


Lys Asp Leu Pro Ala Ala Gly Ser Glu Met Gln Ile Arg Pro Ile Val 
                85                  90                  95


Met Ser Gln Lys Asp Gly Asp Arg Pro Lys Lys Lys Val Thr Phe Asn 
            100                 105                 110


Ser Ser Ser Ile Ile Phe Ile Ile Thr Ser Asp Glu Ser Leu Ser Val 
        115                 120                 125


Asp Asp Ser Asp Lys Thr Asn Gly Ser Lys Val Asp Val Ile Gln Val 
    130                 135                 140


Arg Pro Leu 
145


<210>  2026
<211>  2538
<212>  DNA
<213>  Homo sapiens

<400>  2026
atggctagag caggcggcgg agccccaacc ccacccagtg cggagcgcgc cgcgagcccc     60

gccgcaagct gagcgcctcc gcccgccagg cgcgccggcg ccgggccatg tactcgggga    120

accgcagcgg cggccacggc tactgggacg gcggcggggc cgcgggcgct gaggggccgg    180

cgccggcggg gacactgagc cccgcgcccc tcttcagccc cggcacctac gagcgcctgg    240

cgctgctgct gggctccatt gggctgctgg gcgtcggcaa caacctgctg gtgctcgtcc    300

tctactacaa gttccagcgg ctccgcactc ccactcacct cctcctggtc aacatcagcc    360

tcagcgacct gctggtgtcc ctcttcgggg tcacctttac cttcgtgtcc tgcctgagga    420

acggctgggt gtgggacacc gtgggctgcg tgtgggacgg gtttagcggc agcctcttcg    480

ggattgtttc cattgccacc ctaaccgtgc tggcctatga acgttacatt cgcgtggtcc    540

atgccagagt gatcaatttt tcctgggcct ggagggccat tacctacatc tggctctact    600

cactggcgtg ggcaggagca cctctcctgg gatggaacag gtacatcctg gacgtacacg    660

gactaggctg cactgtggac tggaaatcca aggatgccaa cgattcctcc tttgtgcttt    720

tcttatttct tggctgcctg gtggtgcccc tgggtgtcat agcccattgc tatggccata    780

ttctatattc cattcgaatg cttcgttgtg tggaagatct tcagacaatt caagtgatca    840

agattttaaa atatgaaaag aaactggcca aaatgtgctt tttaatgata ttcaccttcc    900

tggtctgttg gatgccttat atcgtgatct gcttcttggt ggttaatggt catggtcacc    960

tggtcactcc aacaatatct attgtttcgt acctctttgc taaatcgaac actgtataca   1020

atccagtgat ttatgtcttc atgatcagaa agtttcgaag atcccttttg cagcttctgt   1080

gcctccgact gctgaggtgc cagaggcctg ctaaagacct accagcagct ggaagtgaaa   1140

tgcagatcag acccattgtg atgtcacaga aagatgggga caggccaaag aaaaaagtga   1200

ctttcaactc ttcttccatc atttttatca tcaccagtga tgaatcactg tcagttgacg   1260

acagcgacaa aaccaatggg tccaaagttg atgtaatcca agttcgtcct ttgtaggaat   1320

gaagaatggc aacgaaagat ggggccttaa attggatgcc acttttggac tttcatcata   1380

agaagtgtct ggaatacccg ttctatgtaa tatcaacaga accttgtggt ccagcaggaa   1440

atccgaattg cccatatgct cttgggcctc aggaagaggt tgaacaaaaa caaattcttt   1500

taattcaacg ggtgctttac ataatgaaaa aaccacttgt ggcacacgat gggcatctaa   1560

catcatcatc ttctaatgtg ttggagattt tcatttcaaa tatatttttt aaattactct   1620

attttccaaa acacgtaatg catttttctc gaaaatacct tactgtaaaa ataactgtcg   1680

cgtacacatg tgtgaagtag ctagaacata ctgaattttt tttgtactgt tggactctat   1740

tcagtgtcat gtcctatatc tgatcaagtt atcaaggaga taattctaga atgaaaaaga   1800

aaatcctctt gttggaaaca aaagacgttt tatatgtgca gtatgacaaa gaggagtttc   1860

agagacaact ttgaatcctt gtcagcctgg agaccagcac cagaggaatc tacaaggcaa   1920

actcccatat atttgcttcc cccaaattgc tgcccctaca gactcaaagc tctttttctt   1980

tgttttgttg tttctctaaa aatttactgt tctttgtcga tgctatataa gccagggagt   2040

tctaagacgc cagctctttg agatttgctc attcccctgt atttcccaca tatatattac   2100

atatacccgc taataaattt atgtttgttt ttctcttgtc aatctgtctt ttgttatagg   2160

ggccccagcc aaggaaccta aagtgggtag aaggaaaaat tattttttct ttccctacaa   2220

actgaacatg gattattaga actcaaggtt ttcattgaca atatagaaaa gaaacactga   2280

atcattttat tttattgccc aatttttatt tcttatatga ctctagtgtt tcatcttcat   2340

aattaatcat gtttgaagga tttctgagtg actcagcagc ctgttaaaga aggatgaacc   2400

aaagaaaaca tttcactaaa tgtgctttta aaaatcaagt gtattgctgg ttctgctgca   2460

gtatgtagtc gaagaataaa ttagtaaatt gcttctgagg gtctgaaatt gaataaagta   2520

atggctttgt atttctat                                                 2538


<210>  2027
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  2027

Met Tyr Ser Gly Asn Arg Ser Gly Gly His Gly Tyr Trp Asp Gly Gly 
1               5                   10                  15


Gly Ala Ala Gly Ala Glu Gly Pro Ala Pro Ala Gly Thr Leu Ser Pro 
            20                  25                  30


Ala Pro Leu Phe Ser Pro Gly Thr Tyr Glu Arg Leu Ala Leu Leu Leu 
        35                  40                  45


Gly Ser Ile Gly Leu Leu Gly Val Gly Asn Asn Leu Leu Val Leu Val 
    50                  55                  60


Leu Tyr Tyr Lys Phe Gln Arg Leu Arg Thr Pro Thr His Leu Leu Leu 
65                  70                  75                  80


Val Asn Ile Ser Leu Ser Asp Leu Leu Val Ser Leu Phe Gly Val Thr 
                85                  90                  95


Phe Thr Phe Val Ser Cys Leu Arg Asn Gly Trp Val Trp Asp Thr Val 
            100                 105                 110


Gly Cys Val Trp Asp Gly Phe Ser Gly Ser Leu Phe Gly Ile Val Ser 
        115                 120                 125


Ile Ala Thr Leu Thr Val Leu Ala Tyr Glu Arg Tyr Ile Arg Val Val 
    130                 135                 140


His Ala Arg Val Ile Asn Phe Ser Trp Ala Trp Arg Ala Ile Thr Tyr 
145                 150                 155                 160


Ile Trp Leu Tyr Ser Leu Ala Trp Ala Gly Ala Pro Leu Leu Gly Trp 
                165                 170                 175


Asn Arg Tyr Ile Leu Asp Val His Gly Leu Gly Cys Thr Val Asp Trp 
            180                 185                 190


Lys Ser Lys Asp Ala Asn Asp Ser Ser Phe Val Leu Phe Leu Phe Leu 
        195                 200                 205


Gly Cys Leu Val Val Pro Leu Gly Val Ile Ala His Cys Tyr Gly His 
    210                 215                 220


Ile Leu Tyr Ser Ile Arg Met Leu Arg Cys Val Glu Asp Leu Gln Thr 
225                 230                 235                 240


Ile Gln Val Ile Lys Ile Leu Lys Tyr Glu Lys Lys Leu Ala Lys Met 
                245                 250                 255


Cys Phe Leu Met Ile Phe Thr Phe Leu Val Cys Trp Met Pro Tyr Ile 
            260                 265                 270


Val Ile Cys Phe Leu Val Val Asn Gly His Gly His Leu Val Thr Pro 
        275                 280                 285


Thr Ile Ser Ile Val Ser Tyr Leu Phe Ala Lys Ser Asn Thr Val Tyr 
    290                 295                 300


Asn Pro Val Ile Tyr Val Phe Met Ile Arg Lys Phe Arg Arg Ser Leu 
305                 310                 315                 320


Leu Gln Leu Leu Cys Leu Arg Leu Leu Arg Cys Gln Arg Pro Ala Lys 
                325                 330                 335


Asp Leu Pro Ala Ala Gly Ser Glu Met Gln Ile Arg Pro Ile Val Met 
            340                 345                 350


Ser Gln Lys Asp Gly Asp Arg Pro Lys Lys Lys Val Thr Phe Asn Ser 
        355                 360                 365


Ser Ser Ile Ile Phe Ile Ile Thr Ser Asp Glu Ser Leu Ser Val Asp 
    370                 375                 380


Asp Ser Asp Lys Thr Asn Gly Ser Lys Val Asp Val Ile Gln Val Arg 
385                 390                 395                 400


Pro Leu 



<210>  2028
<211>  1812
<212>  DNA
<213>  Homo sapiens

<400>  2028
gaagagttca aaaaggcttt tctaacccgg gactgacttc taggtggaaa aaatacatcg     60

ctgtaagaaa accgcttcgt tgtgtggaag atcttcagac aattcaagtg atcaagattt    120

taaaatatga aaagaaactg gccaaaatgt gctttttaat gatattcacc ttcctggtct    180

gttggatgcc ttatatcgtg atctgcttct tggtggttaa tggtcatggt cacctggtca    240

ctccaacaat atctattgtt tcgtacctct ttgctaaatc gaacactgta tacaatccag    300

tgatttatgt cttcatgatc agaaagtttc gaagatccct tttgcagctt ctgtgcctcc    360

gactgctgag gtgccagagg cctgctaaag acctaccagc agctggaagt gaaatgcaga    420

tcagacccat tgtgatgtca cagaaagatg gggacaggcc aaagaaaaaa gtgactttca    480

actcttcttc catcattttt atcatcacca gtgatgaatc actgtcagtt gacgacagcg    540

acaaaaccaa tgggtccaaa gttgatgtaa tccaagttcg tcctttgtag gaatgaagaa    600

tggcaacgaa agatggggcc ttaaattgga tgccactttt ggactttcat cataagaagt    660

gtctggaata cccgttctat gtaatatcaa cagaaccttg tggtccagca ggaaatccga    720

attgcccata tgctcttggg cctcaggaag aggttgaaca aaaacaaatt cttttaattc    780

aacgggtgct ttacataatg aaaaaaccac ttgtggcaca cgatgggcat ctaacatcat    840

catcttctaa tgtgttggag attttcattt caaatatatt ttttaaatta ctctattttc    900

caaaacacgt aatgcatttt tctcgaaaat accttactgt aaaaataact gtcgcgtaca    960

catgtgtgaa gtagctagaa catactgaat tttttttgta ctgttggact ctattcagtg   1020

tcatgtccta tatctgatca agttatcaag gagataattc tagaatgaaa aagaaaatcc   1080

tcttgttgga aacaaaagac gttttatatg tgcagtatga caaagaggag tttcagagac   1140

aactttgaat ccttgtcagc ctggagacca gcaccagagg aatctacaag gcaaactccc   1200

atatatttgc ttcccccaaa ttgctgcccc tacagactca aagctctttt tctttgtttt   1260

gttgtttctc taaaaattta ctgttctttg tcgatgctat ataagccagg gagttctaag   1320

acgccagctc tttgagattt gctcattccc ctgtatttcc cacatatata ttacatatac   1380

ccgctaataa atttatgttt gtttttctct tgtcaatctg tcttttgtta taggggcccc   1440

agccaaggaa cctaaagtgg gtagaaggaa aaattatttt ttctttccct acaaactgaa   1500

catggattat tagaactcaa ggttttcatt gacaatatag aaaagaaaca ctgaatcatt   1560

ttattttatt gcccaatttt tatttcttat atgactctag tgtttcatct tcataattaa   1620

tcatgtttga aggatttctg agtgactcag cagcctgtta aagaaggatg aaccaaagaa   1680

aacatttcac taaatgtgct tttaaaaatc aagtgtattg ctggttctgc tgcagtatgt   1740

agtcgaagaa taaattagta aattgcttct gagggtctga aattgaataa agtaatggct   1800

ttgtatttct at                                                       1812


<210>  2029
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  2029

Met Cys Phe Leu Met Ile Phe Thr Phe Leu Val Cys Trp Met Pro Tyr 
1               5                   10                  15


Ile Val Ile Cys Phe Leu Val Val Asn Gly His Gly His Leu Val Thr 
            20                  25                  30


Pro Thr Ile Ser Ile Val Ser Tyr Leu Phe Ala Lys Ser Asn Thr Val 
        35                  40                  45


Tyr Asn Pro Val Ile Tyr Val Phe Met Ile Arg Lys Phe Arg Arg Ser 
    50                  55                  60


Leu Leu Gln Leu Leu Cys Leu Arg Leu Leu Arg Cys Gln Arg Pro Ala 
65                  70                  75                  80


Lys Asp Leu Pro Ala Ala Gly Ser Glu Met Gln Ile Arg Pro Ile Val 
                85                  90                  95


Met Ser Gln Lys Asp Gly Asp Arg Pro Lys Lys Lys Val Thr Phe Asn 
            100                 105                 110


Ser Ser Ser Ile Ile Phe Ile Ile Thr Ser Asp Glu Ser Leu Ser Val 
        115                 120                 125


Asp Asp Ser Asp Lys Thr Asn Gly Ser Lys Val Asp Val Ile Gln Val 
    130                 135                 140


Arg Pro Leu 
145


<210>  2030
<211>  1960
<212>  DNA
<213>  Homo sapiens

<400>  2030
aagctgagcg cctccgcccg ccaggcgcgc cggcgccggg ccatgtactc ggggaaccgc     60

agcggcggcc acggctactg ggacggcggc ggggccgcgg gcgctgaggg gccggcgccg    120

gcggggacac tgagccccgc gcccctcttc agccccggca cctacgagcg cctggcgctg    180

ctgctgggct ccattgggct gctgggcgtc ggcaacaacc tgctggtgct cgtcctctac    240

tacaagttcc agcggctccg cactcccact cacctcctcc tggtcaacat cagcctcagc    300

gacctgctgg tgtccctctt cggggtcacc tttaccttcg tgtcctgcct gaggaacggc    360

tgggtgtggg acaccgtggg ctgcgtgtgg gacgggttta gcggcagcct cttcggttgg    420

atcagccagc ttcaggcagc cactagggaa gccagagcct ccatgggtcc agtgcagcaa    480

ggcactatct gcatgcagac ggagtctcac tctgttgccc aggctggagt gcattggcat    540

gatctcggct gactgcaacc tccacctcat ggattccagc gattctcctg cttcagcctc    600

ccaagtagct gggactacag cttcgttgtg tggaagatct tcagacaatt caagtgatca    660

agattttaaa atatgaaaag aaactggcca aaatgtgctt tttaatgata ttcaccttcc    720

tggtctgttg gatgccttat atcgtgatct gcttcttggt ggttaatggt catggtcacc    780

tggtcactcc aacaatatct attgtttcgt acctctttgc taaatcgaac actgtataca    840

atccagtgat ttatgtcttc atgatcagaa agtttcgaag atcccttttg cagcttctgt    900

gcctccgact gctgaggtgc cagaggcctg ctaaagacct accagcagct ggaagtgaaa    960

tgcagatcag acccattgtg atgtcacaga aagatgggga caggccaaag aaaaaagtga   1020

ctttcaactc ttcttccatc atttttatca tcaccagtga tgaatcactg tcagttgacg   1080

acagcgacaa aaccaatggg tccaaagttg atgtaatcca agttcgtcct ttgtaggaat   1140

gaagaatggc aacgaaagat ggggccttaa attggatgcc acttttggac tttcatcata   1200

agaagtgtct ggaatacccg ttctatgtaa tatcaacaga accttgtggt ccagcaggaa   1260

atccgaattg cccatatgct cttgggcctc aggaagaggt tgaacaaaaa caaattcttt   1320

taattcaacg ggtgctttac ataatgaaaa aaccacttgt ggcacacgat gggcatctaa   1380

catcatcatc ttctaatgtg ttggagattt tcatttcaaa tatatttttt aaattactct   1440

attttccaaa acacgtaatg catttttctc gaaaatacct tactgtaaaa ataactgtcg   1500

cgtacacatg tgtgaagtag ctagaacata ctgaattttt tttgtactgt tggactctat   1560

tcagtgtcat gtcctatatc tgatcaagtt atcaaggaga taattctaga atgaaaaaga   1620

aaatcctctt gttggaaaca aaagacgttt tatatgtgca gtatgacaaa gaggagtttc   1680

agagacaact ttgaatcctt gtcagcctgg agaccagcac cagaggaatc tacaaggcaa   1740

actcccatat atttgcttcc cccaaattgc tgcccctaca gactcaaagc tctttttctt   1800

tgttttgttg tttctctaaa aatttactgt tctttgtcga tgctatataa gccagggagt   1860

tctaagacgc cagctctttg agatttgctc attcccctgt atttcccaca tatatattac   1920

atatacccgc taataaattt atgtttgttt ttctcttgtc                         1960


<210>  2031
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  2031

Met Tyr Ser Gly Asn Arg Ser Gly Gly His Gly Tyr Trp Asp Gly Gly 
1               5                   10                  15


Gly Ala Ala Gly Ala Glu Gly Pro Ala Pro Ala Gly Thr Leu Ser Pro 
            20                  25                  30


Ala Pro Leu Phe Ser Pro Gly Thr Tyr Glu Arg Leu Ala Leu Leu Leu 
        35                  40                  45


Gly Ser Ile Gly Leu Leu Gly Val Gly Asn Asn Leu Leu Val Leu Val 
    50                  55                  60


Leu Tyr Tyr Lys Phe Gln Arg Leu Arg Thr Pro Thr His Leu Leu Leu 
65                  70                  75                  80


Val Asn Ile Ser Leu Ser Asp Leu Leu Val Ser Leu Phe Gly Val Thr 
                85                  90                  95


Phe Thr Phe Val Ser Cys Leu Arg Asn Gly Trp Val Trp Asp Thr Val 
            100                 105                 110


Gly Cys Val Trp Asp Gly Phe Ser Gly Ser Leu Phe Gly Trp Ile Ser 
        115                 120                 125


Gln Leu Gln Ala Ala Thr Arg Glu Ala Arg Ala Ser Met Gly Pro Val 
    130                 135                 140


Gln Gln Gly Thr Ile Cys Met Gln Thr Glu Ser His Ser Val Ala Gln 
145                 150                 155                 160


Ala Gly Val His Trp His Asp Leu Gly 
                165


<210>  2032
<211>  1959
<212>  DNA
<213>  Homo sapiens

<400>  2032
gccccaaccc cacccagtgc ggagcgcgcc gcgagccccg ccgcaagctg agcgcctccg     60

cccgccaggc gcgccggcgc cgggccatgt actcggggaa ccgcagcggc ggccacggct    120

actgggacgg cggcggggcc gcgggcgctg aggggccggc gccggcgggg acactgagcc    180

ccgcgcccct cttcagcccc ggcacctacg agcgcctggc gctgctgctg ggctccattg    240

ggctgctggg cgtcggcaac aacctgctgg tgctcgtcct ctactacaag ttccagcggc    300

tccgcactcc cactcacctc ctcctggtca acatcagcct cagcgacctg ctggtgtccc    360

tcttcggggt cacctttacc ttcgtgtcct gcctgaggaa cggctgggtg tgggacaccg    420

tgggctgcgt gtgggacggg tttagcggca gcctcttcgg gattgtttcc attgccaccc    480

taaccgtgct ggcctatgaa cgttacattc gcgtggtcca tgccagagtg atcaattttt    540

cctgggcctg gagggccatt acctacatct ggctctactc actggcgtgg gcaggagcac    600

ctctcctggg atggaacagc ttcgttgtgt ggaagatctt cagacaattc aagtgatcaa    660

gattttaaaa tatgaaaaga aactggccaa aatgtgcttt ttaatgatat tcaccttcct    720

ggtctgttgg atgccttata tcgtgatctg cttcttggtg gttaatggtc atggtcacct    780

ggtcactcca acaatatcta ttgtttcgta cctctttgct aaatcgaaca ctgtatacaa    840

tccagtgatt tatgtcttca tgatcagaaa gtttcgaaga tcccttttgc agcttctgtg    900

cctccgactg ctgaggtgcc agaggcctgc taaagaccta ccagcagctg gaagtgaaat    960

gcagatcaga cccattgtga tgtcacagaa agatggggac aggccaaaga aaaaagtgac   1020

tttcaactct tcttccatca tttttatcat caccagtgat gaatcactgt cagttgacga   1080

cagcgacaaa accaatgggt ccaaagttga tgtaatccaa gttcgtcctt tgtaggaatg   1140

aagaatggca acgaaagatg gggccttaaa ttggatgcca cttttggact ttcatcataa   1200

gaagtgtctg gaatacccgt tctatgtaat atcaacagaa ccttgtggtc cagcaggaaa   1260

tccgaattgc ccatatgctc ttgggcctca ggaagaggtt gaacaaaaac aaattctttt   1320

aattcaacgg gtgctttaca taatgaaaaa accacttgtg gcacacgatg ggcatctaac   1380

atcatcatct tctaatgtgt tggagatttt catttcaaat atatttttta aattactcta   1440

ttttccaaaa cacgtaatgc atttttctcg aaaatacctt actgtaaaaa taactgtcgc   1500

gtacacatgt gtgaagtagc tagaacatac tgaatttttt ttgtactgtt ggactctatt   1560

cagtgtcatg tcctatatct gatcaagtta tcaaggagat aattctagaa tgaaaaagaa   1620

aatcctcttg ttggaaacaa aagacgtttt atatgtgcag tatgacaaag aggagtttca   1680

gagacaactt tgaatccttg tcagcctgga gaccagcacc agaggaatct acaaggcaaa   1740

ctcccatata tttgcttccc ccaaattgct gcccctacag actcaaagct ctttttcttt   1800

gttttgttgt ttctctaaaa atttactgtt ctttgtcgat gctatataag ccagggagtt   1860

ctaagacgcc agctctttga gatttgctca ttcccctgta tttcccacat atatattaca   1920

tatacccgct aataaattta tgtttgtttt tctcttgtc                          1959


<210>  2033
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  2033

Met Tyr Ser Gly Asn Arg Ser Gly Gly His Gly Tyr Trp Asp Gly Gly 
1               5                   10                  15


Gly Ala Ala Gly Ala Glu Gly Pro Ala Pro Ala Gly Thr Leu Ser Pro 
            20                  25                  30


Ala Pro Leu Phe Ser Pro Gly Thr Tyr Glu Arg Leu Ala Leu Leu Leu 
        35                  40                  45


Gly Ser Ile Gly Leu Leu Gly Val Gly Asn Asn Leu Leu Val Leu Val 
    50                  55                  60


Leu Tyr Tyr Lys Phe Gln Arg Leu Arg Thr Pro Thr His Leu Leu Leu 
65                  70                  75                  80


Val Asn Ile Ser Leu Ser Asp Leu Leu Val Ser Leu Phe Gly Val Thr 
                85                  90                  95


Phe Thr Phe Val Ser Cys Leu Arg Asn Gly Trp Val Trp Asp Thr Val 
            100                 105                 110


Gly Cys Val Trp Asp Gly Phe Ser Gly Ser Leu Phe Gly Ile Val Ser 
        115                 120                 125


Ile Ala Thr Leu Thr Val Leu Ala Tyr Glu Arg Tyr Ile Arg Val Val 
    130                 135                 140


His Ala Arg Val Ile Asn Phe Ser Trp Ala Trp Arg Ala Ile Thr Tyr 
145                 150                 155                 160


Ile Trp Leu Tyr Ser Leu Ala Trp Ala Gly Ala Pro Leu Leu Gly Trp 
                165                 170                 175


Asn Ser Phe Val Val Trp Lys Ile Phe Arg Gln Phe Lys 
            180                 185


<210>  2034
<211>  1814
<212>  DNA
<213>  Homo sapiens

<400>  2034
agagcaggcg gcggagcccc aaccccaccc agtgcggagc gcgccgcgag ccccgccgca     60

agctgagcgc ctccgcccgc caggcgcgcc ggcgccgggc catgtactcg gggaaccgca    120

gcggcggcca cggctactgg gacggcggcg gggccgcggg cgctgagggg ccggcgccgg    180

cggggacact gagccccgcg cccctcttca gccccggcac ctacgagcgc ctggcgctgc    240

tgctgggctc cattgggctg ctgggcgtcg gcaacaacct gctggtgctc gtcctctact    300

acaagttcca gcggctccgc actcccactc acctcctcct ggtcaacatc agcctcagcg    360

acctgctggt gtccctcttc ggggtcacct ttaccttcgt gtcctgcctg aggaacggct    420

gggtgtggga caccgtgggc tgcgtgtggg acgggtttag cggcagcctc ttcgcttcgt    480

tgtgtggaag atcttcagac aattcaagtg atcaagattt taaaatatga aaagaaactg    540

gccaaaatgt gctttttaat gatattcacc ttcctggtct gttggatgcc ttatatcgtg    600

atctgcttct tggtggttaa tggtcatggt cacctggtca ctccaacaat atctattgtt    660

tcgtacctct ttgctaaatc gaacactgta tacaatccag tgatttatgt cttcatgatc    720

agaaagtttc gaagatccct tttgcagctt ctgtgcctcc gactgctgag gtgccagagg    780

cctgctaaag acctaccagc agctggaagt gaaatgcaga tcagacccat tgtgatgtca    840

cagaaagatg gggacaggcc aaagaaaaaa gtgactttca actcttcttc catcattttt    900

atcatcacca gtgatgaatc actgtcagtt gacgacagcg acaaaaccaa tgggtccaaa    960

gttgatgtaa tccaagttcg tcctttgtag gaatgaagaa tggcaacgaa agatggggcc   1020

ttaaattgga tgccactttt ggactttcat cataagaagt gtctggaata cccgttctat   1080

gtaatatcaa cagaaccttg tggtccagca ggaaatccga attgcccata tgctcttggg   1140

cctcaggaag aggttgaaca aaaacaaatt cttttaattc aacgggtgct ttacataatg   1200

aaaaaaccac ttgtggcaca cgatgggcat ctaacatcat catcttctaa tgtgttggag   1260

attttcattt caaatatatt ttttaaatta ctctattttc caaaacacgt aatgcatttt   1320

tctcgaaaat accttactgt aaaaataact gtcgcgtaca catgtgtgaa gtagctagaa   1380

catactgaat tttttttgta ctgttggact ctattcagtg tcatgtccta tatctgatca   1440

agttatcaag gagataattc tagaatgaaa aagaaaatcc tcttgttgga aacaaaagac   1500

gttttatatg tgcagtatga caaagaggag tttcagagac aactttgaat ccttgtcagc   1560

ctggagacca gcaccagagg aatctacaag gcaaactccc atatatttgc ttcccccaaa   1620

ttgctgcccc tacagactca aagctctttt tctttgtttt gttgtttctc taaaaattta   1680

ctgttctttg tcgatgctat ataagccagg gagttctaag acgccagctc tttgagattt   1740

gctcattccc ctgtatttcc cacatatata ttacatatac ccgctaataa atttatgttt   1800

gtttttctct tgtc                                                     1814


<210>  2035
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  2035

Met Cys Phe Leu Met Ile Phe Thr Phe Leu Val Cys Trp Met Pro Tyr 
1               5                   10                  15


Ile Val Ile Cys Phe Leu Val Val Asn Gly His Gly His Leu Val Thr 
            20                  25                  30


Pro Thr Ile Ser Ile Val Ser Tyr Leu Phe Ala Lys Ser Asn Thr Val 
        35                  40                  45


Tyr Asn Pro Val Ile Tyr Val Phe Met Ile Arg Lys Phe Arg Arg Ser 
    50                  55                  60


Leu Leu Gln Leu Leu Cys Leu Arg Leu Leu Arg Cys Gln Arg Pro Ala 
65                  70                  75                  80


Lys Asp Leu Pro Ala Ala Gly Ser Glu Met Gln Ile Arg Pro Ile Val 
                85                  90                  95


Met Ser Gln Lys Asp Gly Asp Arg Pro Lys Lys Lys Val Thr Phe Asn 
            100                 105                 110


Ser Ser Ser Ile Ile Phe Ile Ile Thr Ser Asp Glu Ser Leu Ser Val 
        115                 120                 125


Asp Asp Ser Asp Lys Thr Asn Gly Ser Lys Val Asp Val Ile Gln Val 
    130                 135                 140


Arg Pro Leu 
145


<210>  2036
<211>  2140
<212>  DNA
<213>  Homo sapiens

<400>  2036
atggctagag caggcggcgg agccccaacc ccacccagtg cggagcgcgc cgcgagcccc     60

gccgcaagct gagcgcctcc gcccgccagg cgcgccggcg ccgggccatg tactcgggga    120

accgcagcgg cggccacggc tactgggacg gcggcggggc cgcgggcgct gaggggccgg    180

cgccggcggg gacactgagc cccgcgcccc tcttcagccc cggcacctac gagcgcctgg    240

cgctgctgct gggctccatt gggctgctgg gcgtcggcaa caacctgctg gtgctcgtcc    300

tctactacaa gttccagcgg ctccgcactc ccactcacct cctcctggtc aacatcagcc    360

tcagcgacct gctggtgtcc ctcttcgggg tcacctttac cttcgtgtcc tgcctgagga    420

acggctgggt gtgggacacc gtgggctgcg tgtgggacgg gtttagcggc agcctcttcg    480

ggattgtttc cattgccacc ctaaccgtgc tggcctatga acgttacatt cgcgtggtcc    540

atgccagagt gatcaatttt tcctgggcct ggagggccat tacctacatc tggctctact    600

cactggcgtg ggcaggagca cctctcctgg gatggaacag gtacatcctg gacgtacacg    660

gactaggctg cactgtggac tggaaatcca aggatgccaa cgattcctcc tttgtgcttt    720

tcttatttct tggctgcctg gtggtgcccc tgggtgtcat agcccattgc tatggccata    780

ttctatattc cattcgaatg cttcgttgtg tggaagatct tcagacaatt caagtgatca    840

agattttaaa atatgaaaag aaactggcca aaatgtgctt tttaatgata ttcaccttcc    900

tggtctgttg gatgccttat atcgtgatct gcttcttggt ggttaatggt catggtcacc    960

tggtcactcc aacaatatct attgtttcgt acctctttgc taaatcgaac actgtataca   1020

atccagtgat ttatgtcttc atgatcagaa agtttcgaag atcccttttg cagcttctgt   1080

gcctccgact gctgaggtgc cagaggcctg ctaaagacct accagcagct ggaagtgaaa   1140

tgcagatcag acccattgtg atgtcacaga aagatgggga caggccaaag aaaaaagtga   1200

ctttcaactc ttcttccatc atttttatca tcaccagtga tgaatcactg tcagttgacg   1260

acagcgacaa aaccaatggg tccaaagttg atgtaatcca agttcgtcct ttgtaggaat   1320

gaagaatggc aacgaaagat ggggccttaa attggatgcc acttttggac tttcatcata   1380

agaagtgtct ggaatacccg ttctatgtaa tatcaacaga accttgtggt ccagcaggaa   1440

atccgaattg cccatatgct cttgggcctc aggaagaggt tgaacaaaaa caaattcttt   1500

taattcaacg ggtgctttac ataatgaaaa aaccacttgt ggcacacgat gggcatctaa   1560

catcatcatc ttctaatgtg ttggagattt tcatttcaaa tatatttttt aaattactct   1620

attttccaaa acacgtaatg catttttctc gaaaatacct tactgtaaaa ataactgtcg   1680

cgtacacatg tgtgaagtag ctagaacata ctgaattttt tttgtactgt tggactctat   1740

tcagtgtcat gtcctatatc tgatcaagtt atcaaggaga taattctaga atgaaaaaga   1800

aaatcctctt gttggaaaca aaagacgttt tatatgtgca gtatgacaaa gaggagtttc   1860

agagacaact ttgaatcctt gtcagcctgg agaccagcac cagaggaatc tacaaggcaa   1920

actcccatat atttgcttcc cccaaattgc tgcccctaca gactcaaagc tctttttctt   1980

tgttttgttg tttctctaaa aatttactgt tctttgtcga tgctatataa gccagggagt   2040

tctaagacgc cagctctttg agatttgctc attcccctgt atttcccaca tatatattac   2100

atatacccgc taataaattt atgtttgttt ttctcttgtc                         2140


<210>  2037
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  2037

Met Tyr Ser Gly Asn Arg Ser Gly Gly His Gly Tyr Trp Asp Gly Gly 
1               5                   10                  15


Gly Ala Ala Gly Ala Glu Gly Pro Ala Pro Ala Gly Thr Leu Ser Pro 
            20                  25                  30


Ala Pro Leu Phe Ser Pro Gly Thr Tyr Glu Arg Leu Ala Leu Leu Leu 
        35                  40                  45


Gly Ser Ile Gly Leu Leu Gly Val Gly Asn Asn Leu Leu Val Leu Val 
    50                  55                  60


Leu Tyr Tyr Lys Phe Gln Arg Leu Arg Thr Pro Thr His Leu Leu Leu 
65                  70                  75                  80


Val Asn Ile Ser Leu Ser Asp Leu Leu Val Ser Leu Phe Gly Val Thr 
                85                  90                  95


Phe Thr Phe Val Ser Cys Leu Arg Asn Gly Trp Val Trp Asp Thr Val 
            100                 105                 110


Gly Cys Val Trp Asp Gly Phe Ser Gly Ser Leu Phe Gly Ile Val Ser 
        115                 120                 125


Ile Ala Thr Leu Thr Val Leu Ala Tyr Glu Arg Tyr Ile Arg Val Val 
    130                 135                 140


His Ala Arg Val Ile Asn Phe Ser Trp Ala Trp Arg Ala Ile Thr Tyr 
145                 150                 155                 160


Ile Trp Leu Tyr Ser Leu Ala Trp Ala Gly Ala Pro Leu Leu Gly Trp 
                165                 170                 175


Asn Arg Tyr Ile Leu Asp Val His Gly Leu Gly Cys Thr Val Asp Trp 
            180                 185                 190


Lys Ser Lys Asp Ala Asn Asp Ser Ser Phe Val Leu Phe Leu Phe Leu 
        195                 200                 205


Gly Cys Leu Val Val Pro Leu Gly Val Ile Ala His Cys Tyr Gly His 
    210                 215                 220


Ile Leu Tyr Ser Ile Arg Met Leu Arg Cys Val Glu Asp Leu Gln Thr 
225                 230                 235                 240


Ile Gln Val Ile Lys Ile Leu Lys Tyr Glu Lys Lys Leu Ala Lys Met 
                245                 250                 255


Cys Phe Leu Met Ile Phe Thr Phe Leu Val Cys Trp Met Pro Tyr Ile 
            260                 265                 270


Val Ile Cys Phe Leu Val Val Asn Gly His Gly His Leu Val Thr Pro 
        275                 280                 285


Thr Ile Ser Ile Val Ser Tyr Leu Phe Ala Lys Ser Asn Thr Val Tyr 
    290                 295                 300


Asn Pro Val Ile Tyr Val Phe Met Ile Arg Lys Phe Arg Arg Ser Leu 
305                 310                 315                 320


Leu Gln Leu Leu Cys Leu Arg Leu Leu Arg Cys Gln Arg Pro Ala Lys 
                325                 330                 335


Asp Leu Pro Ala Ala Gly Ser Glu Met Gln Ile Arg Pro Ile Val Met 
            340                 345                 350


Ser Gln Lys Asp Gly Asp Arg Pro Lys Lys Lys Val Thr Phe Asn Ser 
        355                 360                 365


Ser Ser Ile Ile Phe Ile Ile Thr Ser Asp Glu Ser Leu Ser Val Asp 
    370                 375                 380


Asp Ser Asp Lys Thr Asn Gly Ser Lys Val Asp Val Ile Gln Val Arg 
385                 390                 395                 400


Pro Leu 



<210>  2038
<211>  1414
<212>  DNA
<213>  Homo sapiens

<400>  2038
gaagagttca aaaaggcttt tctaacccgg gactgacttc taggtggaaa aaatacatcg     60

ctgtaagaaa accgcttcgt tgtgtggaag atcttcagac aattcaagtg atcaagattt    120

taaaatatga aaagaaactg gccaaaatgt gctttttaat gatattcacc ttcctggtct    180

gttggatgcc ttatatcgtg atctgcttct tggtggttaa tggtcatggt cacctggtca    240

ctccaacaat atctattgtt tcgtacctct ttgctaaatc gaacactgta tacaatccag    300

tgatttatgt cttcatgatc agaaagtttc gaagatccct tttgcagctt ctgtgcctcc    360

gactgctgag gtgccagagg cctgctaaag acctaccagc agctggaagt gaaatgcaga    420

tcagacccat tgtgatgtca cagaaagatg gggacaggcc aaagaaaaaa gtgactttca    480

actcttcttc catcattttt atcatcacca gtgatgaatc actgtcagtt gacgacagcg    540

acaaaaccaa tgggtccaaa gttgatgtaa tccaagttcg tcctttgtag gaatgaagaa    600

tggcaacgaa agatggggcc ttaaattgga tgccactttt ggactttcat cataagaagt    660

gtctggaata cccgttctat gtaatatcaa cagaaccttg tggtccagca ggaaatccga    720

attgcccata tgctcttggg cctcaggaag aggttgaaca aaaacaaatt cttttaattc    780

aacgggtgct ttacataatg aaaaaaccac ttgtggcaca cgatgggcat ctaacatcat    840

catcttctaa tgtgttggag attttcattt caaatatatt ttttaaatta ctctattttc    900

caaaacacgt aatgcatttt tctcgaaaat accttactgt aaaaataact gtcgcgtaca    960

catgtgtgaa gtagctagaa catactgaat tttttttgta ctgttggact ctattcagtg   1020

tcatgtccta tatctgatca agttatcaag gagataattc tagaatgaaa aagaaaatcc   1080

tcttgttgga aacaaaagac gttttatatg tgcagtatga caaagaggag tttcagagac   1140

aactttgaat ccttgtcagc ctggagacca gcaccagagg aatctacaag gcaaactccc   1200

atatatttgc ttcccccaaa ttgctgcccc tacagactca aagctctttt tctttgtttt   1260

gttgtttctc taaaaattta ctgttctttg tcgatgctat ataagccagg gagttctaag   1320

acgccagctc tttgagattt gctcattccc ctgtatttcc cacatatata ttacatatac   1380

ccgctaataa atttatgttt gtttttctct tgtc                               1414


<210>  2039
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  2039

Met Cys Phe Leu Met Ile Phe Thr Phe Leu Val Cys Trp Met Pro Tyr 
1               5                   10                  15


Ile Val Ile Cys Phe Leu Val Val Asn Gly His Gly His Leu Val Thr 
            20                  25                  30


Pro Thr Ile Ser Ile Val Ser Tyr Leu Phe Ala Lys Ser Asn Thr Val 
        35                  40                  45


Tyr Asn Pro Val Ile Tyr Val Phe Met Ile Arg Lys Phe Arg Arg Ser 
    50                  55                  60


Leu Leu Gln Leu Leu Cys Leu Arg Leu Leu Arg Cys Gln Arg Pro Ala 
65                  70                  75                  80


Lys Asp Leu Pro Ala Ala Gly Ser Glu Met Gln Ile Arg Pro Ile Val 
                85                  90                  95


Met Ser Gln Lys Asp Gly Asp Arg Pro Lys Lys Lys Val Thr Phe Asn 
            100                 105                 110


Ser Ser Ser Ile Ile Phe Ile Ile Thr Ser Asp Glu Ser Leu Ser Val 
        115                 120                 125


Asp Asp Ser Asp Lys Thr Asn Gly Ser Lys Val Asp Val Ile Gln Val 
    130                 135                 140


Arg Pro Leu 
145


<210>  2040
<211>  7078
<212>  DNA
<213>  Homo sapiens

<400>  2040
ataagaaaaa aaatatttta aaagggtaac cgttaaacag ctaggacctg caacttcagt     60

gcttctggga taactggaac atcagaagga cagattttat tacagcataa tcacacctca    120

tttctttcat cagcagttgt caccagacgc tgttacttcc taaaatggcg gacaatcttc    180

ccacagagtt tgatgtggtt ataataggga caggtttgcc cgaatccatc cttgcagctg    240

catgttcaag aagtggtcag agggttctgc atattgattc aagaagctac tatggaggaa    300

actgggctag tttcagcttt tcaggattgc tatcctggtt gaaggagtat cagcaaaaca    360

atgacattgg ggaagaaagt actgttgtat ggcaggacct gatccatgaa acagaagaag    420

ccatcactct tcgcaagaag gatgaaacta ttcaacacac agaagctttt tgctacgcca    480

gtcaggatat ggaggacaac gttgaagaga ttggtgctct gcagaaaaat ccttctttgg    540

gggtgtctaa taccttcact gaagttctgg attctgcatt acctgaagaa agccagttat    600

cgtattttaa tagcgacgaa atgcctgcaa aacacactca gaaaagtgat acagagattt    660

cactagaagt aactgatgta gaggaatcag tggagaagga aaagtattgt ggagataaaa    720

cttgtatgca cacagtttca gataaagatg gagataaaga tgaaagcaaa tctacagtag    780

aagataaggc cgatgaacca attagaaata ggattactta ctctcaaata gttaaagaag    840

gcaggaggtt taatattgat ttggtgtcaa aactgctgta ttctcaagga ttgctaattg    900

atcttttaat caaatcagat gttagtcgtt atgtagaatt taaaaatgtc actaggattc    960

ttgcatttcg ggaaggaaag gtagaacaag ttccttgttc cagagcagat gtctttaata   1020

gcaaggaact caccatggtt gaaaagagga tgctaatgaa atttctcaca ttttgtttag   1080

agtatgaaca acatcctgat gaataccaag ctttcaggca gtgttcattt tcagaatact   1140

taaaaactaa aaaactaact cccaaccttc aacattttgt actgcactca attgcaatga   1200

catcagaatc atcttgcact acaatagatg gtcttaacgc aactaaaaac ttccttcagt   1260

gtctcggacg gtttggcaac accccctttt tatttccctt gtatggccaa ggagaaattc   1320

cccagggttt ctgtaggatg tgtgcagttt ttggtggaat ctattgtctt cgtcataaag   1380

tacaatgctt tgtagtcgac aaagaatctg gacgatgtaa agcaattata gatcactttg   1440

gtcaaagaat aaatgctaaa tattttattg tggaagacag ttacctttct gaggaaacat   1500

gctcaaatgt gcagtataag cagatctcta gggcagtact cattacagat cagtctatac   1560

taaagacaga tttagatcag cagacttcca ttctgatagt tcctccagca gagccaggag   1620

cttgtgctgt acgggtcaca gaattatgtt cttcaaccat gacatgcatg aaggacacct   1680

atctggtaca tttgacatgt tcatcttcta aaacagcaag agaagactta gaatcagtgg   1740

tgaagaaatt attcactccg tatactgaaa cagaaataaa cgaggaagaa cttacaaagc   1800

caagactctt gtgggctctt tattttaata tgagagattc ctcgggaatc agcagaagct   1860

cgtataatgg cttgccttcc aatgtttatg tctgctctgg gcctgactgt ggcctgggaa   1920

atgagcatgc tgtcaagcaa gctgaaacac ttttccagga gatctttcca actgaagaat   1980

tctgccctcc acctccaaat ccagaagaca ttatctttga tggtgatgat aagcagccag   2040

aggctcctgg aaccaataat gtagtaatgg ccaaactaga atcctctgag gaaagcaaaa   2100

acctagaaag cccagagaag caccttcaaa attagaaaag agcaatctcg aaatgctgtt   2160

ttggacctcc ttcatggcat cagaattttc tcatttaaag gacagtttcc catatgagta   2220

attagaagtg gttatatatg atgaatgcta tgcagatgtt gtctttaact ctcagacatt   2280

cagcattgaa tatctttgtt aacctatcaa tgagtgattt attgattatt gaacattttg   2340

tttagaatgg gctatatgac ccagaatctt aaaacagagt tagctttatt ttagtattgg   2400

gtatatatgt aagggttcca tattagcaac tcagcttaaa ggtaatgtat ttgctaatga   2460

tcttcagatt ttatctttgt ctacagaaca attagtaata cccaagtaat attttaatta   2520

cttttgcagc tgttacagtt gctgcggcct gttcgaatag tgaaacatac acaaatggta   2580

aattatgtgg atcttttgca tataatataa atgtatagac atggtggtag gaatagcaac   2640

taatacaaat gccaatatga taataaaata catttgtcta taatcgttta aagattagct   2700

ttgcatgatc ctttatgcac tgtgaaggtc tgaagtttat aatactcact tgacccttgt   2760

aactgatgag gcaatgatgc caccacagta ttctaattta caaaaagaat tggagttcaa   2820

ttagtggttg taaagctcat tttggggagg ttgattgcaa aggaaatttg aaagataaga   2880

tttattctta tttaatactt cagaaaattt ctgcagagcc ctgccctggc acttaaaata   2940

gcttccaata agtaacttag accaaaagga aaaatgaagt gccccaggag aagatacttc   3000

agaagggctg ttctgaaatt cctaaggagg aattcttagg aattcctaag gagaaacaga   3060

gtgaggcctt tttaacctga gattacagat acttataaaa ccctctataa atagattacc   3120

caaggttttt cagtgagaat gaaacatacc accttgttgg ctctaccact ttaattaata   3180

tcactataac ataactgata ggaatgaatc aaaggaggat ttaccatgcc ctttcggttg   3240

tgtcccactt aacaaattgt gaagtaacaa ttttctgtaa tctctcttgc ctcttagctg   3300

ttatccagag tatagaaact ttttttctcc cagagccacc caacgtcata aaactggtag   3360

tactctaatg gtgaaaacct gtggagctgt cagaagacat gaacttgctt ttcctctagt   3420

ccagtttcca ttcttcagtc agagtatgat gatccctgtg acagtttttg ctctgaaata   3480

gtatttatca tgtgtttggt acctagtatt atgctttctc atgacagttt ctcaacaatc   3540

ctgtgaggca aattcgcatg taccctctgt attagtgtgt tctcatgctg ttgataaaga   3600

cacacctgag atggtaattt gtaaagaaaa aggtttaatg gactcacagt tccatgtggc   3660

tggggaggcc tcacaatcat ggtggaaggt gaaaggcacg tcttacatgg cggtggacaa   3720

gagagaatga gaactaagtg aaaagggaaa cccttttaaa accatcagat atcgtgagac   3780

ttatttacta ccatgagaac agtatggggg aaacaactcc atgattcagt tatctcccac   3840

caggttcctc ccacaacacg tgggaattat aggagctaca attcaagatg agatttgagt   3900

gggaacacag ccaaaccata tcaccttcaa agaagaaata agagaattat tagtaatttg   3960

ctcagaatct ggtatgtgga agagccaaca tggggaccca gccttttgtg attctaaaac   4020

ctttgatctt tctactaaca ttcactgtta gagagtgtag gcgctgcagg agaaagagaa   4080

agtgcccacg aaaattagtc tagcattgcc gggggtaaaa agcacacact ggtcctgcag   4140

cttattgaat cagagaaatg tgaagataag atgaactaaa caaacatatt ttagagcatg   4200

gatctcgaag cagaatttgg ctaaatttta acaaaatgtt cttcagtaac acatctcatg   4260

atctgaagat tgtgttacaa aaaatattat caggccaaaa tttgttcgga atacactaat   4320

ttttgctcct ctatatgtga ggaaaatgag actagacaga tttaagtaat tgacaactta   4380

cttaaagtag caaagtcatg gattgtattg acttttaaaa atatagtaaa agtcatattt   4440

aaactttatc ctaaagttta aatctaacag aacaactgaa atacttgaaa tagacctata   4500

aaatagtaat taaaatgaga aatacataag atgataaata aaatgaaggt gaaggtattc   4560

cagatctacc gaaaagattt tcagtatcac agattattca taagaaattg agaaaaggaa   4620

caatcagaag ttgcaaaaga tggtatagcc gaatataatg gaaataggaa aaattagtcg   4680

aaaataaagg ttgatttaga aatgaagaaa atgaatatat ttcttaatac aaaataagtg   4740

ggaaatgaga agttatacca ataaaaagca tttaaaaatt taggggatat tgtaacccag   4800

tataattttc tgacaggttg gactttgacc ctaatggact tactggtgaa ctttttcaaa   4860

tgtttaaata atgtctatcc atgtatcatg aaggacagta tgcttcaaat tgtcttttga   4920

ggcagacatg ttctcagtac taaaagacat ttttagaagg attttattct caacagatgc   4980

aaaatgcaaa ataaaatatt ggcaaacaat acagcaacaa ataatttact atcactcagg   5040

attataaggc tggtgttaag cagaacagcc attaaatcag catcaaaaga acaaatagta   5100

aaatccaaag tattaattac agataacttt tcaaaaattc atcattcacc cttgatttaa   5160

ttatttctct ggcaatgatt taatagactt ctcggagtct gttaagtact taaaccaaga   5220

actaccatta ttcctactgg gaaaacataa acatttctca agtggaaagt aaacagtgtt   5280

ggcactattt ttatatatgg ttaaagagac ctgtcattgc aataaaagcc agcattcaca   5340

aaatgaggaa gataaggaaa gtagcataaa tattttctat taacatggct ttacaactgc   5400

taaaacttat agtataaaaa tgtactaaca aagactaatt caagaagttg caggatacac   5460

aatttttaaa aatctcattt ctacatctta gcagtgacaa actgcaattt aaaaagtgtg   5520

tttggttatt aatatatatg agacttttaa agaaagttat ataactacat agagataaat   5580

taagaaagat gcctaaatag aagcaagttt aaagagctat atttttaaac atgaacaaac   5640

tcccatggga gccatgccag tgtagtggaa aagtagtaca tggggagatg gggagttttt   5700

ttgaaaacca gaattacagt tctcatttca ctacttacca gttgtatact cttgggaaag   5760

tcactcctag tatctatttc accatctaca gaagagaaat acttcacaga attattgtgg   5820

ggattaagtt agataatgtg ttttaaaata taaagctaca tccaaagaaa tgccaatatg   5880

tgacattagt atgaaattta ctacagttcc atttaacatt ccaactggtt gctgtgtgga   5940

atatggcata attgtaataa attatttagg aaagcaagca aagatgtaag tttttttaat   6000

ttagggggaa aaaatgggag ccttgctctc caaatcctta aaacatgcta ttaagcaacc   6060

tttctgaata ttctgtggtg ccaagtagaa agtttaactg aaattaataa gccaatggaa   6120

agaaagaaat attaataact gctggtggaa agactagcta gatgtcagtg tggaaagatt   6180

agatccactt tacatgtgat attccaaatg aattaaaatg ttaagtataa aaagaaaaat   6240

actacaagtc tcacaccaat agtggtataa aggaacttca tggcaattgg caaggtagat   6300

caactaagag aaaaagtttt aaatgtgtag taaataggaa aaagacaaaa caagatggaa   6360

tttaaaagaa gctatttgca ttacacatgg atgcactcag tttttgtaaa actatatgca   6420

tatccataag ggtttgtact cttaggcaaa tttataaagc gatcgtgtat aaatgatata   6480

aaaaatcaat ttgaatggta ttcaaatttc ctaatattaa aaatgcaact ttgacttagt   6540

tcatgctatt gtattagcaa aactgtttta attgcatgtg tccttatagc agcagcattg   6600

tgtattagta gccttttaag agaactgtgt agaagactat aaaaagggct ttataactga   6660

tcttttgaca tactcacttt gagtggcata tgcccaggaa aatatttaaa agaaagaaaa   6720

gctatttgta caaagttttc tagcagttcc actcagataa ctttaagggg gaaaaaagcc   6780

caacgattgg aaatggttaa gtaaattttg gtgtattgct agtgctatca cagaatgtta   6840

tatagccatt caataatatt gatatatgtc aaattgtatg caaaaaagtg agattcaaaa   6900

atgttaataa gaacataaat tgtgtttact gatacatgtg aaaatttagg tctacattga   6960

aaagaatcag aagataacat gtaattcagt ttaacattag gggttcttta tttttcttct   7020

gttaaatatt gatgtatgca ataaaaaata aaagattaat tggtaaagtg gtttactg     7078


<210>  2041
<211>  656
<212>  PRT
<213>  Homo sapiens

<400>  2041

Met Ala Asp Asn Leu Pro Thr Glu Phe Asp Val Val Ile Ile Gly Thr 
1               5                   10                  15


Gly Leu Pro Glu Ser Ile Leu Ala Ala Ala Cys Ser Arg Ser Gly Gln 
            20                  25                  30


Arg Val Leu His Ile Asp Ser Arg Ser Tyr Tyr Gly Gly Asn Trp Ala 
        35                  40                  45


Ser Phe Ser Phe Ser Gly Leu Leu Ser Trp Leu Lys Glu Tyr Gln Gln 
    50                  55                  60


Asn Asn Asp Ile Gly Glu Glu Ser Thr Val Val Trp Gln Asp Leu Ile 
65                  70                  75                  80


His Glu Thr Glu Glu Ala Ile Thr Leu Arg Lys Lys Asp Glu Thr Ile 
                85                  90                  95


Gln His Thr Glu Ala Phe Cys Tyr Ala Ser Gln Asp Met Glu Asp Asn 
            100                 105                 110


Val Glu Glu Ile Gly Ala Leu Gln Lys Asn Pro Ser Leu Gly Val Ser 
        115                 120                 125


Asn Thr Phe Thr Glu Val Leu Asp Ser Ala Leu Pro Glu Glu Ser Gln 
    130                 135                 140


Leu Ser Tyr Phe Asn Ser Asp Glu Met Pro Ala Lys His Thr Gln Lys 
145                 150                 155                 160


Ser Asp Thr Glu Ile Ser Leu Glu Val Thr Asp Val Glu Glu Ser Val 
                165                 170                 175


Glu Lys Glu Lys Tyr Cys Gly Asp Lys Thr Cys Met His Thr Val Ser 
            180                 185                 190


Asp Lys Asp Gly Asp Lys Asp Glu Ser Lys Ser Thr Val Glu Asp Lys 
        195                 200                 205


Ala Asp Glu Pro Ile Arg Asn Arg Ile Thr Tyr Ser Gln Ile Val Lys 
    210                 215                 220


Glu Gly Arg Arg Phe Asn Ile Asp Leu Val Ser Lys Leu Leu Tyr Ser 
225                 230                 235                 240


Gln Gly Leu Leu Ile Asp Leu Leu Ile Lys Ser Asp Val Ser Arg Tyr 
                245                 250                 255


Val Glu Phe Lys Asn Val Thr Arg Ile Leu Ala Phe Arg Glu Gly Lys 
            260                 265                 270


Val Glu Gln Val Pro Cys Ser Arg Ala Asp Val Phe Asn Ser Lys Glu 
        275                 280                 285


Leu Thr Met Val Glu Lys Arg Met Leu Met Lys Phe Leu Thr Phe Cys 
    290                 295                 300


Leu Glu Tyr Glu Gln His Pro Asp Glu Tyr Gln Ala Phe Arg Gln Cys 
305                 310                 315                 320


Ser Phe Ser Glu Tyr Leu Lys Thr Lys Lys Leu Thr Pro Asn Leu Gln 
                325                 330                 335


His Phe Val Leu His Ser Ile Ala Met Thr Ser Glu Ser Ser Cys Thr 
            340                 345                 350


Thr Ile Asp Gly Leu Asn Ala Thr Lys Asn Phe Leu Gln Cys Leu Gly 
        355                 360                 365


Arg Phe Gly Asn Thr Pro Phe Leu Phe Pro Leu Tyr Gly Gln Gly Glu 
    370                 375                 380


Ile Pro Gln Gly Phe Cys Arg Met Cys Ala Val Phe Gly Gly Ile Tyr 
385                 390                 395                 400


Cys Leu Arg His Lys Val Gln Cys Phe Val Val Asp Lys Glu Ser Gly 
                405                 410                 415


Arg Cys Lys Ala Ile Ile Asp His Phe Gly Gln Arg Ile Asn Ala Lys 
            420                 425                 430


Tyr Phe Ile Val Glu Asp Ser Tyr Leu Ser Glu Glu Thr Cys Ser Asn 
        435                 440                 445


Val Gln Tyr Lys Gln Ile Ser Arg Ala Val Leu Ile Thr Asp Gln Ser 
    450                 455                 460


Ile Leu Lys Thr Asp Leu Asp Gln Gln Thr Ser Ile Leu Ile Val Pro 
465                 470                 475                 480


Pro Ala Glu Pro Gly Ala Cys Ala Val Arg Val Thr Glu Leu Cys Ser 
                485                 490                 495


Ser Thr Met Thr Cys Met Lys Asp Thr Tyr Leu Val His Leu Thr Cys 
            500                 505                 510


Ser Ser Ser Lys Thr Ala Arg Glu Asp Leu Glu Ser Val Val Lys Lys 
        515                 520                 525


Leu Phe Thr Pro Tyr Thr Glu Thr Glu Ile Asn Glu Glu Glu Leu Thr 
    530                 535                 540


Lys Pro Arg Leu Leu Trp Ala Leu Tyr Phe Asn Met Arg Asp Ser Ser 
545                 550                 555                 560


Gly Ile Ser Arg Ser Ser Tyr Asn Gly Leu Pro Ser Asn Val Tyr Val 
                565                 570                 575


Cys Ser Gly Pro Asp Cys Gly Leu Gly Asn Glu His Ala Val Lys Gln 
            580                 585                 590


Ala Glu Thr Leu Phe Gln Glu Ile Phe Pro Thr Glu Glu Phe Cys Pro 
        595                 600                 605


Pro Pro Pro Asn Pro Glu Asp Ile Ile Phe Asp Gly Asp Asp Lys Gln 
    610                 615                 620


Pro Glu Ala Pro Gly Thr Asn Asn Val Val Met Ala Lys Leu Glu Ser 
625                 630                 635                 640


Ser Glu Glu Ser Lys Asn Leu Glu Ser Pro Glu Lys His Leu Gln Asn 
                645                 650                 655


<210>  2042
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  2042
ctttagtaga ggtttatgtc caaataagat gtcacactcc aatggattgt cattgttgca     60

tgaaattatt tttctcttat attgtttaca atgtattctt tcttgaattt tcttctttca    120

gagaagagtt ccagtcacaa atgcatatat gatgcatttt gacatttact gctaagatga    180

aatgcagaaa tgaaaccaca catccatttt agtattctca gatgtgatta gatgtacttg    240

ctcatgtttt tatgctactg acttataaga aaaaaaatat tttaaaaggg taaccgttaa    300

acagctagga cctgcaactt cagtgcttct gggataactg gaacatcaga aggacagatt    360

ttattacagc ataatcacac ctcatttctt tcatcagcag ttgtcaccag acgctgttac    420

ttcctaaaat ggcggacaat cttcccacag agtttgatgt ggttataata gggacaggtt    480

tgcccgaatc catccttgca gctgcatgtt caagaagtgg tcagagggtt ctgcatattg    540

attcaagaag ctactatgga ggaaactggg ctagtttcag cttttcagga ttgctatcct    600

ggttgaagga gtatcagcaa aacaatgaca ttggggaaga aagtactgtt gtatggcagg    660

acctgatcca tgaaacagaa gaagccatca ctcttcgcaa gaaggatgaa actattcaac    720

acacagaagc tttttgctac gccagtcagg atatggagga caacgttgaa gagattggtg    780

ctctgcagaa aaatccttct ttgggggtgt ctaatacctt cactgaagtt ctggattctg    840

cattacctga agaaagccag ttatcgtatt ttaatagcga cgaaatgcct gcaaaacaca    900

ctcagaaaag tgatacagag atttcactag aagtaactga tgtagaggaa tcagtggaga    960

aggaaaagta ttgtggagat aaaacttgta tgcacacagt ttcagataaa gatggagata   1020

aagatgaaag caaatctaca gtagaagata aggccgatga accaattaga aataggatta   1080

cttactctca aatagttaaa gaaggcagga ggtttaatat tgatttggtg tcaaaactgc   1140

tgtattctca aggattgcta attgatcttt taatcaaatc agatgttagt cgttatgtag   1200

aatttaaaaa tgtcactagg attcttgcat ttcgggaagg aaaggtagaa caagttcctt   1260

gttccagagc agatgtcttt aatagcaagg aactcaccat ggttgaaaag aggatgctaa   1320

tgaaatttct cacatttttg ttcattttca                                    1350


<210>  2043
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  2043

Met Ala Asp Asn Leu Pro Thr Glu Phe Asp Val Val Ile Ile Gly Thr 
1               5                   10                  15


Gly Leu Pro Glu Ser Ile Leu Ala Ala Ala Cys Ser Arg Ser Gly Gln 
            20                  25                  30


Arg Val Leu His Ile Asp Ser Arg Ser Tyr Tyr Gly Gly Asn Trp Ala 
        35                  40                  45


Ser Phe Ser Phe Ser Gly Leu Leu Ser Trp Leu Lys Glu Tyr Gln Gln 
    50                  55                  60


Asn Asn Asp Ile Gly Glu Glu Ser Thr Val Val Trp Gln Asp Leu Ile 
65                  70                  75                  80


His Glu Thr Glu Glu Ala Ile Thr Leu Arg Lys Lys Asp Glu Thr Ile 
                85                  90                  95


Gln His Thr Glu Ala Phe Cys Tyr Ala Ser Gln Asp Met Glu Asp Asn 
            100                 105                 110


Val Glu Glu Ile Gly Ala Leu Gln Lys Asn Pro Ser Leu Gly Val Ser 
        115                 120                 125


Asn Thr Phe Thr Glu Val Leu Asp Ser Ala Leu Pro Glu Glu Ser Gln 
    130                 135                 140


Leu Ser Tyr Phe Asn Ser Asp Glu Met Pro Ala Lys His Thr Gln Lys 
145                 150                 155                 160


Ser Asp Thr Glu Ile Ser Leu Glu Val Thr Asp Val Glu Glu Ser Val 
                165                 170                 175


Glu Lys Glu Lys Tyr Cys Gly Asp Lys Thr Cys Met His Thr Val Ser 
            180                 185                 190


Asp Lys Asp Gly Asp Lys Asp Glu Ser Lys Ser Thr Val Glu Asp Lys 
        195                 200                 205


Ala Asp Glu Pro Ile Arg Asn Arg Ile Thr Tyr Ser Gln Ile Val Lys 
    210                 215                 220


Glu Gly Arg Arg Phe Asn Ile Asp Leu Val Ser Lys Leu Leu Tyr Ser 
225                 230                 235                 240


Gln Gly Leu Leu Ile Asp Leu Leu Ile Lys Ser Asp Val Ser Arg Tyr 
                245                 250                 255


Val Glu Phe Lys Asn Val Thr Arg Ile Leu Ala Phe Arg Glu Gly Lys 
            260                 265                 270


Val Glu Gln Val Pro Cys Ser Arg Ala Asp Val Phe Asn Ser Lys Glu 
        275                 280                 285


Leu Thr Met Val Glu Lys Arg Met Leu Met Lys Phe Leu Thr Phe Leu 
    290                 295                 300


Phe Ile 
305


<210>  2044
<211>  769
<212>  DNA
<213>  Homo sapiens

<400>  2044
atagatgggt tccagcacac cagaatcttg ggtgagatta caaatggctc agccaatacc     60

atctcagaga agagttccag tcacaaatgc atatatgatg cattttgaca tttactgcta    120

agatgaaatg cagaaatgaa accacacatc cattttagta ttctcagatg tgattagatg    180

tacttgctca tgtttttatg ctactgactt ataagaaaaa aaatatttta aaagggtaac    240

cgttaaacag ctaggacctg caacttcagt gcttctggga taactggaac atcagaagga    300

cagattttat tacagcataa tcacacctca tttctttcat cagcagttgt caccagacgc    360

tgttacttcc taaaatggcg gacaatcttc ccacagagtt tgatgtggtt ataataggga    420

caggtttgcc cgaatccatc cttgcagctg catgttcaag aagtggtcag agggttctgc    480

atattgattc aagaagctac tatggaggaa actgggctag tttcagcttt tcaggattgc    540

tatcctggtt gaaggagtat cagcaaaaca atgacattgg ggaagaaagt actgttgtat    600

ggcaggacct gatccatgaa acagaagaag ccatcactct tcgcaagaag gatgaaacta    660

ttcaacacac agaagctttt tgctacgcca gtcaggatat ggaggacaac gttgaagaga    720

ttggtgctct gcagaaaaat ccttctttgg gggtgtctaa taccttcac                769


<210>  2045
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  2045

Met Gly Ser Ser Thr Pro Glu Ser Trp Val Arg Leu Gln Met Ala Gln 
1               5                   10                  15


Pro Ile Pro Ser Gln Arg Arg Val Pro Val Thr Asn Ala Tyr Met Met 
            20                  25                  30


His Phe Asp Ile Tyr Cys 
        35


<210>  2046
<211>  1117
<212>  DNA
<213>  Homo sapiens

<400>  2046
aagctgagcg cctccgcccg ccaggcgcgc cggcgccggg ccatgtactc ggggaaccgc     60

agcggcggcc acggctactg ggacggcggc ggggccgcgg gcgctgaggg gccggcgccg    120

gcggggacac tgagccccgc gcccctcttc agccccggca cctacgagcg cctggcgctg    180

ctgctgggct ccattgggct gctgggcgtc ggcaacaacc tgctggtgct cgtcctctac    240

tacaagttcc agcggctccg cactcccact cacctcctcc tggtcaacat cagcctcagc    300

gacctgctgg tgtccctctt cggggtcacc tttaccttcg tgtcctgcct gaggaacggc    360

tgggtgtggg acaccgtggg ctgcgtgtgg gacgggttta gcggcagcct cttcgagaag    420

agttccagtc acaaatgcat atatgatgca ttttgacatt tactgctaag atgaaatgca    480

gaaatgaaac cacacatcca ttttagtatt ctcagatgtg attagatgta cttgctcatg    540

tttttatgct actgacttat aagaaaaaaa atattttaaa agggtaaccg ttaaacagct    600

aggacctgca acttcagtgc ttctgggata actggaacat cagaaggaca gattttatta    660

cagcataatc acacctcatt tctttcatca gcagttgtca ccagacgctg ttacttccta    720

aaatggcgga caatcttccc acagagtttg atgtggttat aatagggaca ggtttgcccg    780

aatccatcct tgcagctgca tgttcaagaa gtggtcagag ggttctgcat attgattcaa    840

gaagctacta tggaggaaac tgggctagtt tcagcttttc aggattgcta tcctggttga    900

aggagtatca gcaaaacaat gacattgggg aagaaagtac tgttgtatgg caggacctga    960

tccatgaaac agaagaagcc atcactcttc gcaagaagga tgaaactatt caacacacag   1020

aagctttttg ctacgccagt caggatatgg aggacaacgt tgaagagatt ggtgctctgc   1080

agaaaaatcc ttctttgggg gtgtctaata ccttcac                            1117


<210>  2047
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  2047

Met Tyr Ser Gly Asn Arg Ser Gly Gly His Gly Tyr Trp Asp Gly Gly 
1               5                   10                  15


Gly Ala Ala Gly Ala Glu Gly Pro Ala Pro Ala Gly Thr Leu Ser Pro 
            20                  25                  30


Ala Pro Leu Phe Ser Pro Gly Thr Tyr Glu Arg Leu Ala Leu Leu Leu 
        35                  40                  45


Gly Ser Ile Gly Leu Leu Gly Val Gly Asn Asn Leu Leu Val Leu Val 
    50                  55                  60


Leu Tyr Tyr Lys Phe Gln Arg Leu Arg Thr Pro Thr His Leu Leu Leu 
65                  70                  75                  80


Val Asn Ile Ser Leu Ser Asp Leu Leu Val Ser Leu Phe Gly Val Thr 
                85                  90                  95


Phe Thr Phe Val Ser Cys Leu Arg Asn Gly Trp Val Trp Asp Thr Val 
            100                 105                 110


Gly Cys Val Trp Asp Gly Phe Ser Gly Ser Leu Phe Glu Lys Ser Ser 
        115                 120                 125


Ser His Lys Cys Ile Tyr Asp Ala Phe 
    130                 135


<210>  2048
<211>  747
<212>  DNA
<213>  Homo sapiens

<400>  2048
aagctgagcg cctccgcccg ccaggcgcgc cggcgccggg ccatgtactc ggggaaccgc     60

agcggcggcc acggctactg ggacggcggc ggggccgcgg gcgctgaggg gccggcgccg    120

gcggggacac tgagccccgc gcccctcttc agccccggca cctacgagcg cctggcgctg    180

ctgctgggct ccattgggct gctgggcgtc ggcaacaacc tgctggtgct cgtcctctac    240

tacaagttcc agcggctccg cactcccact cacctcctcc tggtcaacat cagcctcagc    300

gacctgctgg tgtccctctt cggggtcacc tttaccttcg tgtcctgcct gaggaacggc    360

tgggtgtggg acaccgtggg ctgcgtgtgg gacgggttta gcggcagcct cttcgcagtt    420

gtcaccagac gctgttactt cctaaaatgg cggacaatct tcccacagag tttgatgtgg    480

ttataatagg gacaggtttg cccgaatcca tccttgcagc tgcatgttca agaagtggtc    540

agagggttct gcatattgat tcaagaagct actatggagg aaactgggct agtttcagct    600

tttcaggatt gctatcctgg ttgaaggagt atcagcaaaa caatgacatt ggggaagaaa    660

gtactgttgt atggcaggac ctgatccatg aaacagaaga agccatcact cttcgcaaga    720

aggatgaaac tattcaacac acagaag                                        747


<210>  2049
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  2049

Met Tyr Ser Gly Asn Arg Ser Gly Gly His Gly Tyr Trp Asp Gly Gly 
1               5                   10                  15


Gly Ala Ala Gly Ala Glu Gly Pro Ala Pro Ala Gly Thr Leu Ser Pro 
            20                  25                  30


Ala Pro Leu Phe Ser Pro Gly Thr Tyr Glu Arg Leu Ala Leu Leu Leu 
        35                  40                  45


Gly Ser Ile Gly Leu Leu Gly Val Gly Asn Asn Leu Leu Val Leu Val 
    50                  55                  60


Leu Tyr Tyr Lys Phe Gln Arg Leu Arg Thr Pro Thr His Leu Leu Leu 
65                  70                  75                  80


Val Asn Ile Ser Leu Ser Asp Leu Leu Val Ser Leu Phe Gly Val Thr 
                85                  90                  95


Phe Thr Phe Val Ser Cys Leu Arg Asn Gly Trp Val Trp Asp Thr Val 
            100                 105                 110


Gly Cys Val Trp Asp Gly Phe Ser Gly Ser Leu Phe Ala Val Val Thr 
        115                 120                 125


Arg Arg Cys Tyr Phe Leu Lys Trp Arg Thr Ile Phe Pro Gln Ser Leu 
    130                 135                 140


Met Trp Leu 
145


<210>  2050
<211>  850
<212>  DNA
<213>  Homo sapiens

<400>  2050
agacggttag aaatggcggt tggggcggag cagggggctg gcgcgggaag cggggctgtc     60

tggctcggtt acgcccccac ctcgccagga atctaggagt cggtttgttt tccgaaccca    120

tctccttccg ctctcccgcc cctgcaggct gtgtgccgag cttggaagaa agtgtgaccc    180

gttcgacgga acaaaggaca tgacagcccg gccccgtgcg gccactgcgg agcgttagga    240

acattcccta aaatggcggc cggcgcgtcg gaacagggcg ggaggcggcg gcgcgtgggg    300

gcgggacggg gaggggcgcg gccagccggg cttctgcttc cgcgaccccg gcggtgcagg    360

gcgggtggag tcgcggagta gtcctcatgg ccgccccgcc ggagcccggt gagcccgagg    420

agaggaagtc ccttaagctc ctaggatttt tagatgttga aaatactccc tgcgcccggc    480

attcaatatt gtatggttca ttaggatctg ttgtggctgg ctttggacat tttttgttca    540

ctagtagaat tagaagatca tgtgatgttg gagtaggagg gtttatcttg gtgactttgg    600

gatgctggtt tcattgtagg tataattatg caaagcaaag aatccaggaa agaattgcca    660

gagaagaaat taaaaagaag atattatatg aaggtaccca cctcgatcct gaaagaaaac    720

acaacggcag cagcagcaat tgaacaatct tgagcataga agtcaatgta aacgaagtta    780

agatcaacca cataaaacat ttcatgtgca ataagctctc aatcaagtaa ataaagttta    840

agttgtagtc                                                           850


<210>  2051
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  2051

Met Ala Ala Pro Pro Glu Pro Gly Glu Pro Glu Glu Arg Lys Ser Leu 
1               5                   10                  15


Lys Leu Leu Gly Phe Leu Asp Val Glu Asn Thr Pro Cys Ala Arg His 
            20                  25                  30


Ser Ile Leu Tyr Gly Ser Leu Gly Ser Val Val Ala Gly Phe Gly His 
        35                  40                  45


Phe Leu Phe Thr Ser Arg Ile Arg Arg Ser Cys Asp Val Gly Val Gly 
    50                  55                  60


Gly Phe Ile Leu Val Thr Leu Gly Cys Trp Phe His Cys Arg Tyr Asn 
65                  70                  75                  80


Tyr Ala Lys Gln Arg Ile Gln Glu Arg Ile Ala Arg Glu Glu Ile Lys 
                85                  90                  95


Lys Lys Ile Leu Tyr Glu Gly Thr His Leu Asp Pro Glu Arg Lys His 
            100                 105                 110


Asn Gly Ser Ser Ser Asn 
        115


<210>  2052
<211>  1132
<212>  DNA
<213>  Homo sapiens

<400>  2052
agacggttag aaatggcggt tggggcggag cagggggctg gcgcgggaag cggggctgtc     60

tggctcggtt acgcccccac ctcgccagga atctaggagt cggtttgttt tccgaaccca    120

tctccttccg ctctcccgcc cctgcaggct gtgtgccgag cttggaagaa agtgtgaccc    180

gttcgacgga acaaaggaca tgacagcccg gccccgtgcg gccactgcgg agcgttagga    240

acattcccta aaatggcggc cggcgcgtcg gaacagggcg ggaggcggcg gcgcgtgggg    300

gcgggacggg gaggggcgcg gccagccggg cttctgcttc cgcgaccccg gcggtgcagg    360

gcgggtggag tcgcggagta gtcctcatgg ccgccccgcc ggagcccggt gagcccgagg    420

agaggaagtc ccttaagctc ctaggatttt tagatgttga aaatactccc tgcgcccggc    480

attcaatatt gtatggttca ttaggatctg ttgtggctgg ctttggacat tttttgttca    540

ctagtagaat tagaagatca tgtgatgttg gagtaggagg gtttatcttg gtgactttgg    600

gatgctggtt tcattgtagg tataattatg caaagcaaag aatccaggaa agaattgcca    660

gagaagaaat taaaaagaag atattatatg aaggtaccca cctcgatcct gaaagaaaac    720

acaacggcag cagcagcaat tgaacaatct tgagcataga agtcaatgta aacgaagtta    780

agatcaacca cataaaacat ttcatgtgca ataagctctc aatcaagtaa ataaagttta    840

agttgtagtc atttttttcc cacacttgtg tggaatgaaa acttgccagt ttattctggc    900

cctgtgtcta ctgccaggat agcattctta cgtgttacat atagtggact tgtcatcctt    960

aaaatgtgaa cagaatttat tggcagtgtg gcaaagaatt ataaaacata gtgtttaatg   1020

tacttggagt ttccttgtag tagtaagtat agagtttgat gataagtaaa cgtcccttaa   1080

caaaaacctc aaccttatta ctatcccatt aaaaaacagc aaatacttac tg           1132


<210>  2053
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  2053

Met Ala Ala Pro Pro Glu Pro Gly Glu Pro Glu Glu Arg Lys Ser Leu 
1               5                   10                  15


Lys Leu Leu Gly Phe Leu Asp Val Glu Asn Thr Pro Cys Ala Arg His 
            20                  25                  30


Ser Ile Leu Tyr Gly Ser Leu Gly Ser Val Val Ala Gly Phe Gly His 
        35                  40                  45


Phe Leu Phe Thr Ser Arg Ile Arg Arg Ser Cys Asp Val Gly Val Gly 
    50                  55                  60


Gly Phe Ile Leu Val Thr Leu Gly Cys Trp Phe His Cys Arg Tyr Asn 
65                  70                  75                  80


Tyr Ala Lys Gln Arg Ile Gln Glu Arg Ile Ala Arg Glu Glu Ile Lys 
                85                  90                  95


Lys Lys Ile Leu Tyr Glu Gly Thr His Leu Asp Pro Glu Arg Lys His 
            100                 105                 110


Asn Gly Ser Ser Ser Asn 
        115


<210>  2054
<211>  1222
<212>  DNA
<213>  Homo sapiens

<400>  2054
agacggttag aaatggcggt tggggcggag cagggggctg gcgcgggaag cggggctgtc     60

tggctcggtt acgcccccac ctcgccagga atctaggagt cggtttgttt tccgaaccca    120

tctccttccg ctctcccgcc cctgcaggct gtgtgccgag cttggaagaa agtgtgaccc    180

gttcgacgga acaaaggaca tgacagcccg gccccgtgcg gccactgcgg agcgttagga    240

acattcccta aaatggcggc cggcgcgtcg gaacagggcg ggaggcggcg gcgcgtgggg    300

gcgggacggg gaggggcgcg gccagccggg cttctgcttc cgcgaccccg gcggtgcagg    360

gcgggtggag tcgcggagta gtcctcatgg ccgccccgcc ggagcccggt gagcccgagg    420

agaggaagtc ccttaagctc ctaggatttt tagatgttga aaatactccc tgcgcccggc    480

attcaatatt gtatggttca ttaggatctg ttgtggctgg ctttggacat tttttgttca    540

ctagtagaat tagaagatca tgtgatgttg gagtaggagg gtttatcttg gtgactttgg    600

gatgctggtt tcattgtagg tataattatg caaagcaaag aatccaggaa agaattgcca    660

gagaagaaat taaaaagaag atattatatg aaggtaccca cctcgatcct gaaagaaaac    720

acaacggcag cagcagcaat tgaacaatct tgagcataga agtcaatgta aacgaagtta    780

agatcaacca cataaaacat ttcatgtgca ataagctctc aatcaagtaa ataaagttta    840

agttgtagtc atttttttcc cacacttgtg tggaatgaaa acttgccagt ttattctggc    900

cctgtgtcta ctgccaggat agcattctta cgtgttacat atagtggact tgtcatcctt    960

aaaatgtgaa cagaatttat tggcagtgtg gcaaagaatt ataaaacata gtgtttaatg   1020

tacttggagt ttccttgtag tagtaagtat agagtttgat gataagtaaa cgtcccttaa   1080

caaaaacctc aaccttatta ctatcccatt aaaaaacagc aaatacttac tgagttcttg   1140

taagagctaa tgtcattgta agatttaaaa ctaagggctt ttatcacttt gcaaattatt   1200

ttttaaatgc attcatcatt tg                                            1222


<210>  2055
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  2055

Met Ala Ala Pro Pro Glu Pro Gly Glu Pro Glu Glu Arg Lys Ser Leu 
1               5                   10                  15


Lys Leu Leu Gly Phe Leu Asp Val Glu Asn Thr Pro Cys Ala Arg His 
            20                  25                  30


Ser Ile Leu Tyr Gly Ser Leu Gly Ser Val Val Ala Gly Phe Gly His 
        35                  40                  45


Phe Leu Phe Thr Ser Arg Ile Arg Arg Ser Cys Asp Val Gly Val Gly 
    50                  55                  60


Gly Phe Ile Leu Val Thr Leu Gly Cys Trp Phe His Cys Arg Tyr Asn 
65                  70                  75                  80


Tyr Ala Lys Gln Arg Ile Gln Glu Arg Ile Ala Arg Glu Glu Ile Lys 
                85                  90                  95


Lys Lys Ile Leu Tyr Glu Gly Thr His Leu Asp Pro Glu Arg Lys His 
            100                 105                 110


Asn Gly Ser Ser Ser Asn 
        115


<210>  2056
<211>  1352
<212>  DNA
<213>  Homo sapiens

<400>  2056
agacggttag aaatggcggt tggggcggag cagggggctg gcgcgggaag cggggctgtc     60

tggctcggtt acgcccccac ctcgccagga atctaggagt cggtttgttt tccgaaccca    120

tctccttccg ctctcccgcc cctgcaggct gtgtgccgag cttggaagaa agtgtgaccc    180

gttcgacgga acaaaggaca tgacagcccg gccccgtgcg gccactgcgg agcgttagga    240

acattcccta aaatggcggc cggcgcgtcg gaacagggcg ggaggcggcg gcgcgtgggg    300

gcgggacggg gaggggcgcg gccagccggg cttctgcttc cgcgaccccg gcggtgcagg    360

gcgggtggag tcgcggagta gtcctcatgg ccgccccgcc ggagcccggt gagcccgagg    420

agaggaagtc ccttaagctc ctaggatttt tagatgttga aaatactccc tgcgcccggc    480

attcaatatt gtatggttca ttaggatctg ttgtggctgg ctttggacat tttttgttca    540

ctagtagaat tagaagatca tgtgatgttg gagtaggagg gtttatcttg gtgactttgg    600

gatgctggtt tcattgtagg tataattatg caaagcaaag aatccaggaa agaattgcca    660

gagaagaaat taaaaagaag atattatatg aaggtaccca cctcgatcct gaaagaaaac    720

acaacggcag cagcagcaat tgaacaatct tgagcataga agtcaatgta aacgaagtta    780

agatcaacca cataaaacat ttcatgtgca ataagctctc aatcaagtaa ataaagttta    840

agttgtagtc atttttttcc cacacttgtg tggaatgaaa acttgccagt ttattctggc    900

cctgtgtcta ctgccaggat agcattctta cgtgttacat atagtggact tgtcatcctt    960

aaaatgtgaa cagaatttat tggcagtgtg gcaaagaatt ataaaacata gtgtttaatg   1020

tacttggagt ttccttgtag tagtaagtat agagtttgat gataagtaaa cgtcccttaa   1080

caaaaacctc aaccttatta ctatcccatt aaaaaacagc aaatacttac tgagttcttg   1140

taagagctaa tgtcattgta agatttaaaa ctaagggctt ttatcacttt gcaaattatt   1200

ttttaaatgc attcatcatt tgacagtgtt ctctcatttc ttaaaatgcg agtcatcttc   1260

caaaagagtt gtttttaact gccctaaaca tttttgggga agtatgcagg gtttaaattt   1320

ttaagtataa ttagttctga attaaaatat gc                                 1352


<210>  2057
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  2057

Met Ala Ala Pro Pro Glu Pro Gly Glu Pro Glu Glu Arg Lys Ser Leu 
1               5                   10                  15


Lys Leu Leu Gly Phe Leu Asp Val Glu Asn Thr Pro Cys Ala Arg His 
            20                  25                  30


Ser Ile Leu Tyr Gly Ser Leu Gly Ser Val Val Ala Gly Phe Gly His 
        35                  40                  45


Phe Leu Phe Thr Ser Arg Ile Arg Arg Ser Cys Asp Val Gly Val Gly 
    50                  55                  60


Gly Phe Ile Leu Val Thr Leu Gly Cys Trp Phe His Cys Arg Tyr Asn 
65                  70                  75                  80


Tyr Ala Lys Gln Arg Ile Gln Glu Arg Ile Ala Arg Glu Glu Ile Lys 
                85                  90                  95


Lys Lys Ile Leu Tyr Glu Gly Thr His Leu Asp Pro Glu Arg Lys His 
            100                 105                 110


Asn Gly Ser Ser Ser Asn 
        115


<210>  2058
<211>  2622
<212>  DNA
<213>  Homo sapiens

<400>  2058
agacggttag aaatggcggt tggggcggag cagggggctg gcgcgggaag cggggctgtc     60

tggctcggtt acgcccccac ctcgccagga atctaggagt cggtttgttt tccgaaccca    120

tctccttccg ctctcccgcc cctgcaggct gtgtgccgag cttggaagaa agtgtgaccc    180

gttcgacgga acaaaggaca tgacagcccg gccccgtgcg gccactgcgg agcgttagga    240

acattcccta aaatggcggc cggcgcgtcg gaacagggcg ggaggcggcg gcgcgtgggg    300

gcgggacggg gaggggcgcg gccagccggg cttctgcttc cgcgaccccg gcggtgcagg    360

gcgggtggag tcgcggagta gtcctcatgg ccgccccgcc ggagcccggt gagcccgagg    420

agaggaagtc ccttaagctc ctaggatttt tagatgttga aaatactccc tgcgcccggc    480

attcaatatt gtatggttca ttaggatctg ttgtggctgg ctttggacat tttttgttca    540

ctagtagaat tagaagatca tgtgatgttg gagtaggagg gtttatcttg gtgactttgg    600

gatgctggtt tcattgtagg tataattatg caaagcaaag aatccaggaa agaattgcca    660

gagaagaaat taaaaagaag atattatatg aaggtaccca cctcgatcct gaaagaaaac    720

acaacggcag cagcagcaat tgaacaatct tgagcataga agtcaatgta aacgaagtta    780

agatcaacca cataaaacat ttcatgtgca ataagctctc aatcaagtaa ataaagttta    840

agttgtagtc atttttttcc cacacttgtg tggaatgaaa acttgccagt ttattctggc    900

cctgtgtcta ctgccaggat agcattctta cgtgttacat atagtggact tgtcatcctt    960

aaaatgtgaa cagaatttat tggcagtgtg gcaaagaatt ataaaacata gtgtttaatg   1020

tacttggagt ttccttgtag tagtaagtat agagtttgat gataagtaaa cgtcccttaa   1080

caaaaacctc aaccttatta ctatcccatt aaaaaacagc aaatacttac tgagttcttg   1140

taagagctaa tgtcattgta agatttaaaa ctaagggctt ttatcacttt gcaaattatt   1200

ttttaaatgc attcatcatt tgacagtgtt ctctcatttc ttaaaatgcg agtcatcttc   1260

caaaagagtt gtttttaact gccctaaaca tttttgggga agtatgcagg gtttaaattt   1320

ttaagtataa ttagttctga attaaaatat gcacatggaa cttgtctggc agactgatgc   1380

aatagtaaaa caactgcaga attactatta atgtaaacaa tccatttgaa agtcaatcag   1440

ctgctcccat taaaatatta tttaaaatac aatacccaca gcatctaact aaatcctcag   1500

gatttattct ccgggagaaa ttatcccttt ctaggaaaat gaagttattt ctggttttaa   1560

ttcatacaat actttaagaa aatctgttaa atataacaaa acacaagcta gatgcttaag   1620

aaatgcttaa agaaatattg gggcgaaggt aacagcagtc aacaggattg tggccattac   1680

tggtcctatt attttgatgt accatggaag gcacagaaat cgagcaagga agaaaatatt   1740

agttattttg atctacatct ttttctaaag aaaagtggag cttgcctcca gttcaattca   1800

caagagcatt ttccctccca tgcccacctt ttcttgtggc tgtcgctagg aaggatgcag   1860

aggctgtgtg gtttaccaaa tgccttaact tagcagtgaa tgacaactgt caaacacatg   1920

ttgagggaaa atttttactg attcacaaaa aggaagacag tttgcccact cttagtggca   1980

caaatcaaag ctgcatgcac tacattatcc aaattagtcg taaccaaata gttaaaaaat   2040

tctgctgggc acggtggctc atacctgtaa tcccagcact ttgggaggcc gaggcagttg   2100

gatcacctga ggttaggagt ttgagaccag cctggccaac agggtgaaac cctgtctcgt   2160

ctaaaaatac aaaaattagc cgggcgtggt ggtgcatgcc tgtagtccca ggtactcagg   2220

aggctgaggc aggagaatca cttgaacccg aggtggggca ggcggaggtt gcagtaagcc   2280

aagatcgcgc cattgcactc tagcctaggt gacagagtga gactccatct caaaaaaaaa   2340

aaaaaattcc ataggatgtt caaccatgtt ttcagaggcc gcactgcatg aatgcgggaa   2400

aatgttgatg atcactaatc aataatctga tatttaacaa aatatggaca ggccacttat   2460

gctcagtttt accttagtta ttccttggta tccacaggcc caagtccctt taaataaaat   2520

accctcatat ttccatataa tctacataca ttctcccata tactttaaat catctctaga   2580

ttacttataa tgtctaatac aaaataaatg ctatgtaaat gt                      2622


<210>  2059
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  2059

Met Ala Ala Pro Pro Glu Pro Gly Glu Pro Glu Glu Arg Lys Ser Leu 
1               5                   10                  15


Lys Leu Leu Gly Phe Leu Asp Val Glu Asn Thr Pro Cys Ala Arg His 
            20                  25                  30


Ser Ile Leu Tyr Gly Ser Leu Gly Ser Val Val Ala Gly Phe Gly His 
        35                  40                  45


Phe Leu Phe Thr Ser Arg Ile Arg Arg Ser Cys Asp Val Gly Val Gly 
    50                  55                  60


Gly Phe Ile Leu Val Thr Leu Gly Cys Trp Phe His Cys Arg Tyr Asn 
65                  70                  75                  80


Tyr Ala Lys Gln Arg Ile Gln Glu Arg Ile Ala Arg Glu Glu Ile Lys 
                85                  90                  95


Lys Lys Ile Leu Tyr Glu Gly Thr His Leu Asp Pro Glu Arg Lys His 
            100                 105                 110


Asn Gly Ser Ser Ser Asn 
        115


<210>  2060
<211>  2937
<212>  DNA
<213>  Homo sapiens

<400>  2060
agacggttag aaatggcggt tggggcggag cagggggctg gcgcgggaag cggggctgtc     60

tggctcggtt acgcccccac ctcgccagga atctaggagt cggtttgttt tccgaaccca    120

tctccttccg ctctcccgcc cctgcaggct gtgtgccgag cttggaagaa agtgtgaccc    180

gttcgacgga acaaaggaca tgacagcccg gccccgtgcg gccactgcgg agcgttagga    240

acattcccta aaatggcggc cggcgcgtcg gaacagggcg ggaggcggcg gcgcgtgggg    300

gcgggacggg gaggggcgcg gccagccggg cttctgcttc cgcgaccccg gcggtgcagg    360

gcgggtggag tcgcggagta gtcctcatgg ccgccccgcc ggagcccggt gagcccgagg    420

agaggaagtc ccttaagctc ctaggatttt tagatgttga aaatactccc tgcgcccggc    480

attcaatatt gtatggttca ttaggatctg ttgtggctgg ctttggacat tttttgttca    540

ctagtagaat tagaagatca tgtgatgttg gagtaggagg gtttatcttg gtgactttgg    600

gatgctggtt tcattgtagg tataattatg caaagcaaag aatccaggaa agaattgcca    660

gagaagaaat taaaaagaag atattatatg aaggtaccca cctcgatcct gaaagaaaac    720

acaacggcag cagcagcaat tgaacaatct tgagcataga agtcaatgta aacgaagtta    780

agatcaacca cataaaacat ttcatgtgca ataagctctc aatcaagtaa ataaagttta    840

agttgtagtc atttttttcc cacacttgtg tggaatgaaa acttgccagt ttattctggc    900

cctgtgtcta ctgccaggat agcattctta cgtgttacat atagtggact tgtcatcctt    960

aaaatgtgaa cagaatttat tggcagtgtg gcaaagaatt ataaaacata gtgtttaatg   1020

tacttggagt ttccttgtag tagtaagtat agagtttgat gataagtaaa cgtcccttaa   1080

caaaaacctc aaccttatta ctatcccatt aaaaaacagc aaatacttac tgagttcttg   1140

taagagctaa tgtcattgta agatttaaaa ctaagggctt ttatcacttt gcaaattatt   1200

ttttaaatgc attcatcatt tgacagtgtt ctctcatttc ttaaaatgcg agtcatcttc   1260

caaaagagtt gtttttaact gccctaaaca tttttgggga agtatgcagg gtttaaattt   1320

ttaagtataa ttagttctga attaaaatat gcacatggaa cttgtctggc agactgatgc   1380

aatagtaaaa caactgcaga attactatta atgtaaacaa tccatttgaa agtcaatcag   1440

ctgctcccat taaaatatta tttaaaatac aatacccaca gcatctaact aaatcctcag   1500

gatttattct ccgggagaaa ttatcccttt ctaggaaaat gaagttattt ctggttttaa   1560

ttcatacaat actttaagaa aatctgttaa atataacaaa acacaagcta gatgcttaag   1620

aaatgcttaa agaaatattg gggcgaaggt aacagcagtc aacaggattg tggccattac   1680

tggtcctatt attttgatgt accatggaag gcacagaaat cgagcaagga agaaaatatt   1740

agttattttg atctacatct ttttctaaag aaaagtggag cttgcctcca gttcaattca   1800

caagagcatt ttccctccca tgcccacctt ttcttgtggc tgtcgctagg aaggatgcag   1860

aggctgtgtg gtttaccaaa tgccttaact tagcagtgaa tgacaactgt caaacacatg   1920

ttgagggaaa atttttactg attcacaaaa aggaagacag tttgcccact cttagtggca   1980

caaatcaaag ctgcatgcac tacattatcc aaattagtcg taaccaaata gttaaaaaat   2040

tctgctgggc acggtggctc atacctgtaa tcccagcact ttgggaggcc gaggcagttg   2100

gatcacctga ggttaggagt ttgagaccag cctggccaac agggtgaaac cctgtctcgt   2160

ctaaaaatac aaaaattagc cgggcgtggt ggtgcatgcc tgtagtccca ggtactcagg   2220

aggctgaggc aggagaatca cttgaacccg aggtggggca ggcggaggtt gcagtaagcc   2280

aagatcgcgc cattgcactc tagcctaggt gacagagtga gactccatct caaaaaaaaa   2340

aaaaaattcc ataggatgtt caaccatgtt ttcagaggcc gcactgcatg aatgcgggaa   2400

aatgttgatg atcactaatc aataatctga tatttaacaa aatatggaca ggccacttat   2460

gctcagtttt accttagtta ttccttggta tccacaggcc caagtccctt taaataaaat   2520

accctcatat ttccatataa tctacataca ttctcccata tactttaaat catctctaga   2580

ttacttataa tgtctaatac aaaataaatg ctatgtaaat gtaattatta tactgtgtat   2640

ttttgttgtt gttcttcatt gttatttttt gtctttttac ctccagtatt ttcaacccac   2700

agttggttga atccaaggat gcagaactgg aggacatgga gggctgacgt gtaacataca   2760

taacatataa aacaggtccc ttccagcgct agcacactgc aattacatct taccctgaat   2820

aagagagaaa ctctgttttg gctggtaaaa tttccaatgt cttcaccaat aacaaagctc   2880

attttcacag aagtttgcat aaactggaaa cctggataaa aacaaagttg taacata      2937


<210>  2061
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  2061

Met Ala Ala Pro Pro Glu Pro Gly Glu Pro Glu Glu Arg Lys Ser Leu 
1               5                   10                  15


Lys Leu Leu Gly Phe Leu Asp Val Glu Asn Thr Pro Cys Ala Arg His 
            20                  25                  30


Ser Ile Leu Tyr Gly Ser Leu Gly Ser Val Val Ala Gly Phe Gly His 
        35                  40                  45


Phe Leu Phe Thr Ser Arg Ile Arg Arg Ser Cys Asp Val Gly Val Gly 
    50                  55                  60


Gly Phe Ile Leu Val Thr Leu Gly Cys Trp Phe His Cys Arg Tyr Asn 
65                  70                  75                  80


Tyr Ala Lys Gln Arg Ile Gln Glu Arg Ile Ala Arg Glu Glu Ile Lys 
                85                  90                  95


Lys Lys Ile Leu Tyr Glu Gly Thr His Leu Asp Pro Glu Arg Lys His 
            100                 105                 110


Asn Gly Ser Ser Ser Asn 
        115


<210>  2062
<211>  727
<212>  DNA
<213>  Homo sapiens

<400>  2062
agaaatggcg gttggggcgg agcagggggc tggcgcggga agcggggctg tctggctcgg     60

ttacgccccc acctcgccag gaatctagga gtcggtttgt tttccgaacc catctccttc    120

cgctctcccg cccctgcagg ctgtgtgccg agcttggaag aaagtgtgac ccgttcgacg    180

gaacaaagga catgacagcc cggccccgtg cggccactgc ggagcgttag gaacattccc    240

taaaatggcg gccggcgcgt cggaacaggg cgggaggcgg cggcgcgtgg gggcgggacg    300

gggaggggcg cggccagccg ggcttctgct tccgcgaccc cggcggtgca gggcgggtgg    360

agtcgcggag tagtcctcat ggccgccccg ccggagcccg gtgagcccga ggagaggaag    420

gtagaattag aagatcatgt gatgttggag taggagggtt tatcttggtg actttgggat    480

gctggtttca ttgtaggtat aattatgcaa agcaaagaat ccaggaaaga attgccagag    540

aagaaattaa aaagaagata ttatatgaag gtacccacct cgatcctgaa agaaaacaca    600

acggcagcag cagcaattga acaatcttga gcatagaagt caatgtaaac gaagttaaga    660

tcaaccacat aaaacatttc atgtgcaata agctctcaat caagtaaata aagtttaagt    720

tgtagtc                                                              727


<210>  2063
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  2063

Met Ala Ala Gly Ala Ser Glu Gln Gly Gly Arg Arg Arg Arg Val Gly 
1               5                   10                  15


Ala Gly Arg Gly Gly Ala Arg Pro Ala Gly Leu Leu Leu Pro Arg Pro 
            20                  25                  30


Arg Arg Cys Arg Ala Gly Gly Val Ala Glu 
        35                  40


<210>  2064
<211>  1009
<212>  DNA
<213>  Homo sapiens

<400>  2064
agaaatggcg gttggggcgg agcagggggc tggcgcggga agcggggctg tctggctcgg     60

ttacgccccc acctcgccag gaatctagga gtcggtttgt tttccgaacc catctccttc    120

cgctctcccg cccctgcagg ctgtgtgccg agcttggaag aaagtgtgac ccgttcgacg    180

gaacaaagga catgacagcc cggccccgtg cggccactgc ggagcgttag gaacattccc    240

taaaatggcg gccggcgcgt cggaacaggg cgggaggcgg cggcgcgtgg gggcgggacg    300

gggaggggcg cggccagccg ggcttctgct tccgcgaccc cggcggtgca gggcgggtgg    360

agtcgcggag tagtcctcat ggccgccccg ccggagcccg gtgagcccga ggagaggaag    420

gtagaattag aagatcatgt gatgttggag taggagggtt tatcttggtg actttgggat    480

gctggtttca ttgtaggtat aattatgcaa agcaaagaat ccaggaaaga attgccagag    540

aagaaattaa aaagaagata ttatatgaag gtacccacct cgatcctgaa agaaaacaca    600

acggcagcag cagcaattga acaatcttga gcatagaagt caatgtaaac gaagttaaga    660

tcaaccacat aaaacatttc atgtgcaata agctctcaat caagtaaata aagtttaagt    720

tgtagtcatt tttttcccac acttgtgtgg aatgaaaact tgccagttta ttctggccct    780

gtgtctactg ccaggatagc attcttacgt gttacatata gtggacttgt catccttaaa    840

atgtgaacag aatttattgg cagtgtggca aagaattata aaacatagtg tttaatgtac    900

ttggagtttc cttgtagtag taagtataga gtttgatgat aagtaaacgt cccttaacaa    960

aaacctcaac cttattacta tcccattaaa aaacagcaaa tacttactg               1009


<210>  2065
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  2065

Met Ala Ala Gly Ala Ser Glu Gln Gly Gly Arg Arg Arg Arg Val Gly 
1               5                   10                  15


Ala Gly Arg Gly Gly Ala Arg Pro Ala Gly Leu Leu Leu Pro Arg Pro 
            20                  25                  30


Arg Arg Cys Arg Ala Gly Gly Val Ala Glu 
        35                  40


<210>  2066
<211>  2499
<212>  DNA
<213>  Homo sapiens

<400>  2066
agaaatggcg gttggggcgg agcagggggc tggcgcggga agcggggctg tctggctcgg     60

ttacgccccc acctcgccag gaatctagga gtcggtttgt tttccgaacc catctccttc    120

cgctctcccg cccctgcagg ctgtgtgccg agcttggaag aaagtgtgac ccgttcgacg    180

gaacaaagga catgacagcc cggccccgtg cggccactgc ggagcgttag gaacattccc    240

taaaatggcg gccggcgcgt cggaacaggg cgggaggcgg cggcgcgtgg gggcgggacg    300

gggaggggcg cggccagccg ggcttctgct tccgcgaccc cggcggtgca gggcgggtgg    360

agtcgcggag tagtcctcat ggccgccccg ccggagcccg gtgagcccga ggagaggaag    420

gtagaattag aagatcatgt gatgttggag taggagggtt tatcttggtg actttgggat    480

gctggtttca ttgtaggtat aattatgcaa agcaaagaat ccaggaaaga attgccagag    540

aagaaattaa aaagaagata ttatatgaag gtacccacct cgatcctgaa agaaaacaca    600

acggcagcag cagcaattga acaatcttga gcatagaagt caatgtaaac gaagttaaga    660

tcaaccacat aaaacatttc atgtgcaata agctctcaat caagtaaata aagtttaagt    720

tgtagtcatt tttttcccac acttgtgtgg aatgaaaact tgccagttta ttctggccct    780

gtgtctactg ccaggatagc attcttacgt gttacatata gtggacttgt catccttaaa    840

atgtgaacag aatttattgg cagtgtggca aagaattata aaacatagtg tttaatgtac    900

ttggagtttc cttgtagtag taagtataga gtttgatgat aagtaaacgt cccttaacaa    960

aaacctcaac cttattacta tcccattaaa aaacagcaaa tacttactga gttcttgtaa   1020

gagctaatgt cattgtaaga tttaaaacta agggctttta tcactttgca aattattttt   1080

taaatgcatt catcatttga cagtgttctc tcatttctta aaatgcgagt catcttccaa   1140

aagagttgtt tttaactgcc ctaaacattt ttggggaagt atgcagggtt taaattttta   1200

agtataatta gttctgaatt aaaatatgca catggaactt gtctggcaga ctgatgcaat   1260

agtaaaacaa ctgcagaatt actattaatg taaacaatcc atttgaaagt caatcagctg   1320

ctcccattaa aatattattt aaaatacaat acccacagca tctaactaaa tcctcaggat   1380

ttattctccg ggagaaatta tccctttcta ggaaaatgaa gttatttctg gttttaattc   1440

atacaatact ttaagaaaat ctgttaaata taacaaaaca caagctagat gcttaagaaa   1500

tgcttaaaga aatattgggg cgaaggtaac agcagtcaac aggattgtgg ccattactgg   1560

tcctattatt ttgatgtacc atggaaggca cagaaatcga gcaaggaaga aaatattagt   1620

tattttgatc tacatctttt tctaaagaaa agtggagctt gcctccagtt caattcacaa   1680

gagcattttc cctcccatgc ccaccttttc ttgtggctgt cgctaggaag gatgcagagg   1740

ctgtgtggtt taccaaatgc cttaacttag cagtgaatga caactgtcaa acacatgttg   1800

agggaaaatt tttactgatt cacaaaaagg aagacagttt gcccactctt agtggcacaa   1860

atcaaagctg catgcactac attatccaaa ttagtcgtaa ccaaatagtt aaaaaattct   1920

gctgggcacg gtggctcata cctgtaatcc cagcactttg ggaggccgag gcagttggat   1980

cacctgaggt taggagtttg agaccagcct ggccaacagg gtgaaaccct gtctcgtcta   2040

aaaatacaaa aattagccgg gcgtggtggt gcatgcctgt agtcccaggt actcaggagg   2100

ctgaggcagg agaatcactt gaacccgagg tggggcaggc ggaggttgca gtaagccaag   2160

atcgcgccat tgcactctag cctaggtgac agagtgagac tccatctcaa aaaaaaaaaa   2220

aaattccata ggatgttcaa ccatgttttc agaggccgca ctgcatgaat gcgggaaaat   2280

gttgatgatc actaatcaat aatctgatat ttaacaaaat atggacaggc cacttatgct   2340

cagttttacc ttagttattc cttggtatcc acaggcccaa gtccctttaa ataaaatacc   2400

ctcatatttc catataatct acatacattc tcccatatac tttaaatcat ctctagatta   2460

cttataatgt ctaatacaaa ataaatgcta tgtaaatgt                          2499


<210>  2067
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  2067

Met Leu Lys Lys Cys Leu Lys Lys Tyr Trp Gly Glu Gly Asn Ser Ser 
1               5                   10                  15


Gln Gln Asp Cys Gly His Tyr Trp Ser Tyr Tyr Phe Asp Val Pro Trp 
            20                  25                  30


Lys Ala Gln Lys Ser Ser Lys Glu Glu Asn Ile Ser Tyr Phe Asp Leu 
        35                  40                  45


His Leu Phe Leu Lys Lys Ser Gly Ala Cys Leu Gln Phe Asn Ser Gln 
    50                  55                  60


Glu His Phe Pro Ser His Ala His Leu Phe Leu Trp Leu Ser Leu Gly 
65                  70                  75                  80


Arg Met Gln Arg Leu Cys Gly Leu Pro Asn Ala Leu Thr 
                85                  90


<210>  2068
<211>  2814
<212>  DNA
<213>  Homo sapiens

<400>  2068
agaaatggcg gttggggcgg agcagggggc tggcgcggga agcggggctg tctggctcgg     60

ttacgccccc acctcgccag gaatctagga gtcggtttgt tttccgaacc catctccttc    120

cgctctcccg cccctgcagg ctgtgtgccg agcttggaag aaagtgtgac ccgttcgacg    180

gaacaaagga catgacagcc cggccccgtg cggccactgc ggagcgttag gaacattccc    240

taaaatggcg gccggcgcgt cggaacaggg cgggaggcgg cggcgcgtgg gggcgggacg    300

gggaggggcg cggccagccg ggcttctgct tccgcgaccc cggcggtgca gggcgggtgg    360

agtcgcggag tagtcctcat ggccgccccg ccggagcccg gtgagcccga ggagaggaag    420

gtagaattag aagatcatgt gatgttggag taggagggtt tatcttggtg actttgggat    480

gctggtttca ttgtaggtat aattatgcaa agcaaagaat ccaggaaaga attgccagag    540

aagaaattaa aaagaagata ttatatgaag gtacccacct cgatcctgaa agaaaacaca    600

acggcagcag cagcaattga acaatcttga gcatagaagt caatgtaaac gaagttaaga    660

tcaaccacat aaaacatttc atgtgcaata agctctcaat caagtaaata aagtttaagt    720

tgtagtcatt tttttcccac acttgtgtgg aatgaaaact tgccagttta ttctggccct    780

gtgtctactg ccaggatagc attcttacgt gttacatata gtggacttgt catccttaaa    840

atgtgaacag aatttattgg cagtgtggca aagaattata aaacatagtg tttaatgtac    900

ttggagtttc cttgtagtag taagtataga gtttgatgat aagtaaacgt cccttaacaa    960

aaacctcaac cttattacta tcccattaaa aaacagcaaa tacttactga gttcttgtaa   1020

gagctaatgt cattgtaaga tttaaaacta agggctttta tcactttgca aattattttt   1080

taaatgcatt catcatttga cagtgttctc tcatttctta aaatgcgagt catcttccaa   1140

aagagttgtt tttaactgcc ctaaacattt ttggggaagt atgcagggtt taaattttta   1200

agtataatta gttctgaatt aaaatatgca catggaactt gtctggcaga ctgatgcaat   1260

agtaaaacaa ctgcagaatt actattaatg taaacaatcc atttgaaagt caatcagctg   1320

ctcccattaa aatattattt aaaatacaat acccacagca tctaactaaa tcctcaggat   1380

ttattctccg ggagaaatta tccctttcta ggaaaatgaa gttatttctg gttttaattc   1440

atacaatact ttaagaaaat ctgttaaata taacaaaaca caagctagat gcttaagaaa   1500

tgcttaaaga aatattgggg cgaaggtaac agcagtcaac aggattgtgg ccattactgg   1560

tcctattatt ttgatgtacc atggaaggca cagaaatcga gcaaggaaga aaatattagt   1620

tattttgatc tacatctttt tctaaagaaa agtggagctt gcctccagtt caattcacaa   1680

gagcattttc cctcccatgc ccaccttttc ttgtggctgt cgctaggaag gatgcagagg   1740

ctgtgtggtt taccaaatgc cttaacttag cagtgaatga caactgtcaa acacatgttg   1800

agggaaaatt tttactgatt cacaaaaagg aagacagttt gcccactctt agtggcacaa   1860

atcaaagctg catgcactac attatccaaa ttagtcgtaa ccaaatagtt aaaaaattct   1920

gctgggcacg gtggctcata cctgtaatcc cagcactttg ggaggccgag gcagttggat   1980

cacctgaggt taggagtttg agaccagcct ggccaacagg gtgaaaccct gtctcgtcta   2040

aaaatacaaa aattagccgg gcgtggtggt gcatgcctgt agtcccaggt actcaggagg   2100

ctgaggcagg agaatcactt gaacccgagg tggggcaggc ggaggttgca gtaagccaag   2160

atcgcgccat tgcactctag cctaggtgac agagtgagac tccatctcaa aaaaaaaaaa   2220

aaattccata ggatgttcaa ccatgttttc agaggccgca ctgcatgaat gcgggaaaat   2280

gttgatgatc actaatcaat aatctgatat ttaacaaaat atggacaggc cacttatgct   2340

cagttttacc ttagttattc cttggtatcc acaggcccaa gtccctttaa ataaaatacc   2400

ctcatatttc catataatct acatacattc tcccatatac tttaaatcat ctctagatta   2460

cttataatgt ctaatacaaa ataaatgcta tgtaaatgta attattatac tgtgtatttt   2520

tgttgttgtt cttcattgtt attttttgtc tttttacctc cagtattttc aacccacagt   2580

tggttgaatc caaggatgca gaactggagg acatggaggg ctgacgtgta acatacataa   2640

catataaaac aggtcccttc cagcgctagc acactgcaat tacatcttac cctgaataag   2700

agagaaactc tgttttggct ggtaaaattt ccaatgtctt caccaataac aaagctcatt   2760

ttcacagaag tttgcataaa ctggaaacct ggataaaaac aaagttgtaa cata         2814


<210>  2069
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  2069

Met Leu Lys Lys Cys Leu Lys Lys Tyr Trp Gly Glu Gly Asn Ser Ser 
1               5                   10                  15


Gln Gln Asp Cys Gly His Tyr Trp Ser Tyr Tyr Phe Asp Val Pro Trp 
            20                  25                  30


Lys Ala Gln Lys Ser Ser Lys Glu Glu Asn Ile Ser Tyr Phe Asp Leu 
        35                  40                  45


His Leu Phe Leu Lys Lys Ser Gly Ala Cys Leu Gln Phe Asn Ser Gln 
    50                  55                  60


Glu His Phe Pro Ser His Ala His Leu Phe Leu Trp Leu Ser Leu Gly 
65                  70                  75                  80


Arg Met Gln Arg Leu Cys Gly Leu Pro Asn Ala Leu Thr 
                85                  90


<210>  2070
<211>  2751
<212>  DNA
<213>  Homo sapiens

<400>  2070
ccacttctga gcattttaca gttcagtgta cttaactgta aaggtataca ggctcaagtc     60

gttgcatatt cttcctgttt tgatagaaat tgcagggatt tatgtactga atcttattac    120

tccttagata tgtgacaact ggaaagctcc ccaccaaacc ctccagcctt ggttacttct    180

taatgatgtg gtttggcaca atgaaaatgt cataggcttt gtggtgaaac tgacttctgc    240

ctccactcct gccaacactt attattagcc tcttaagtcc ccgagcctgt ttcagaggta    300

atctcacaca aaggctagag aattaaaaaa catgtagaga gcctggcact aatacctacc    360

tcccccacca gcagctctta attatgagat caaccactat tattttagac cagagttttg    420

ttggggattg ggtttgtttc agaaggcact attttaaata agatgtgtag cttctattta    480

gatatttgcc tttaaagtca gctgagctat tttcctattg tttgcaaatt tacttttatt    540

taaaaaaata aaatttccta aagcagtgtt tccccaatat gacagtcatc agaaaaaacc    600

acctagagtt ttctaaacat agattccagt gattgtaaat cagaatctga gagtgggact    660

agaaaatact taattctatc ctgtggtaca agctggtctc acacttgcat ctttgcacct    720

aagactagat caaactggta ctaatcctct ggccccagca tcccatcctt ggggaaatag    780

tctagtttag aggtagtcct ggactggagc gctaagtcca gcattcctca cctgcataac    840

actacccaca tgatcatatg tcccctgggc tctcaagctg ataggaaaaa gtcgtcttgc    900

taaatgaaat cccccaacct cttggtaatg tgaagaactg tactgcaaag ctttgaagca    960

atcctatgtt aggcatgcgg gtgggaacgg ggccagacag agggaaaaaa tggaatagaa   1020

tgatccgaga gtaaataatt cttgctttat tatgaaccaa gtcacatttt gtctcttcca   1080

acagatgctt gagccaaaaa agcaaacata ggcagaaata caattgagaa tatcttcatg   1140

tttcaacctt taatctgact tgccttttac tatcctttcc ccatttcttc taatctcttt   1200

tgccttacaa tatattacct tctaggtatc acctcatcct atagaatccc ttctagttta   1260

atgtcctgcc ccaaacaata ctaacccatt gaagataact atgaaacctt taaatggaca   1320

gtggttcctt ttaaaagcag ccttactgaa aattttatat acacttaaat caagtaacag   1380

ttaccgtgag ttttctaaac ttttgtgtta acagaaatgc cagttcagca gtgtgactgt   1440

tacttttaaa tgtctgtctt gccgccctag agtgacagac atcccagtta aacatattag   1500

gaataagaaa tacataaatc caatgaagac tgtagaaaaa gaattttagc acttgaagga   1560

acttcagtca tttaacccaa cccattcatg ttatagattg agaccataga aataaaagta   1620

gcctatagga tacaaaagtt agcggcagat ctgagataaa aatccagctc tttggatccc   1680

cgcgtttttc accacactta gctgtcgttc ccatgtatta cgaacaaaga atcaaatata   1740

atcaagtgca gcctcacttc acaggcaaga aaacagacta gagtttaata tattgcccat   1800

gtttatctta aggtgaaaca tttactctta caaccacagt tgatgttaac ctagttaata   1860

aaatatgaaa ggtaattact aggggaattt taaacggcac tacataagca aacatgactc   1920

aaattacttt ttccatttct gcttcccaaa ttattggagt tactgaagca agctatgctg   1980

ctttcaattc caatgatagg catattccca aataaactca tttaaagagc tcataaaatg   2040

aattatccta tttccaagtc agttgattag caaattaaga tacagctcca agttacccta   2100

ctgcttaagg gttttccggt ccaatttgta aggttttcgg atttaaagat tcagactgca   2160

taccaaaggt ggacaaagac aacgcaagct gatttaggtt gtcacgtggc acatactcta   2220

gtttaaaccc tcaactacaa gaaaagaaat ggtgtattgt catttttgcc aaagcacccc   2280

aaaatgaaat actttcttac tcaatctagg ttcttttttt tcattctagt cccttaagct   2340

cctaggattt ttagatgttg aaaatactcc ctgcgcccgg cattcaatat tgtatggttc   2400

attaggatct gttgtggctg gctttggaca ttttttgttc actagtagaa ttagaagatc   2460

atgtgatgtt ggagtaggag ggtttatctt ggtgactttg ggatgctggt ttcattgtag   2520

gtataattat gcaaagcaaa gaatccagga aagaattgcc agagaagaaa ttaaaaagaa   2580

gatattatat gaaggtaccc acctcgatcc tgaaagaaaa cacaacggca gcagcagcaa   2640

ttgaacaatc ttgagcatag aagtcaatgt aaacgaagtt aagatcaacc acataaaaca   2700

tttcatgtgc aataagctct caatcaagta aataaagttt aagttgtagt c            2751


<210>  2071
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  2071

Met Gln Ser Lys Glu Ser Arg Lys Glu Leu Pro Glu Lys Lys Leu Lys 
1               5                   10                  15


Arg Arg Tyr Tyr Met Lys Val Pro Thr Ser Ile Leu Lys Glu Asn Thr 
            20                  25                  30


Thr Ala Ala Ala Ala Ile Glu Gln Ser 
        35                  40


<210>  2072
<211>  5948
<212>  DNA
<213>  Homo sapiens

<400>  2072
ctctctcaga attagtattt gcctattaat gtaatcagtg tagccttctc aacataaaaa     60

tgtccttatt ctagaacatg gaagcgtacg gcaaatgcaa cggttgaaag cactgaaaaa    120

tatttgtaaa acatctgtag tgctcacatt atgaacttta aatgtaatac tttgaaaacc    180

atcttcataa tttttttgtt ctaacagctt cctttttaag aaaacatttt aaaacatttt    240

aaaatggaac ttaatgtgca aaataagttg tgtaaaatac cagtatttgg gtggtggagg    300

atattggtat attatattga cctgggttga tgactactgg actattttaa gatacctact    360

tccaaaactt attttattct agaggaccac taaaaatcag aattacagca atcattttaa    420

tttttctact ttccttgtta aggtcttctg cttacccaaa gaatagtgta tatcttaaca    480

tgacttttaa aggggtatct tgatccccat cacagatttt tatctatgaa tagaaggatt    540

gaaaccctat ttgatcccta gctctttgct gaaaagtgca taaacaggaa tcctgaattt    600

attatataga cctcctcgca ttatataatc gaagcaaagg gaaaccagcg atggagtaga    660

ggtacgtaga ctaaagagat gcttgcaaat gatggtacct agggatagtc acattttctt    720

gttgccaaac tcagacaata taatcacaag tccagagaag agctagttaa ttttaaattc    780

cccgaggtcc ttttactgag atggaaaagc acaaacagtc aaggaaaacc aaagagggag    840

gggtgaggga aggggaaagt gcataaagca cttaaagatt ttttaaaagt aggtatgata    900

gataagccac aagaagtttt taagactact aataaccata attctatttt aatcagctat    960

ttagctggta cctactgcta tatcacctag tgtgacattt cggaattaat ggaacaatga   1020

aggaagctgt acactggagg ttccaggtgg tcatggaagg tttccagttt atgcaaactt   1080

ctgtgaaaat gagctttgtt attggtgaag acattggaaa ttttaccagc caaaacagag   1140

tttctctctt attcagggta agatgtaatt gcagtgtgct agcgctggaa gggacctgtt   1200

ttatatgtta tgtatgttac acgtcagccc tccatgtcct ccagttctgc atccttggat   1260

tcaaccaact gtgggttgaa aatactggag gtaaaaagac aaaaaataac aatgaagaac   1320

aacaacaaaa atacacagta taataattac atttacatag catttatttt gtattagaca   1380

ttataagtaa tctagagatg atttaaagta tatgggagaa tgtatgtaga ttatatggaa   1440

atatgagggt attttattta aagggacttg ggcctgtgga taccaaggaa taactaaggt   1500

aaaactgagc ataagtggcc tgtccatatt ttgttaaata tcagattatt gattagtgat   1560

catcaacatt ttcccgcatt catgcagtgc ggcctctgaa aacatggttg aacatcctat   1620

ggaatttttt tttttttttg agatggagtc tcactctgtc acctaggcta gagtgcaatg   1680

gcgcgatctt ggcttactgc aacctccgcc tgccccacct cgggttcaag tgattctcct   1740

gcctcagcct cctgagtacc tgggactaca ggcatgcacc accacgcccg gctaattttt   1800

gtatttttag acgagacagg gtttcaccct gttggccagg ctggtctcaa actcctaacc   1860

tcaggtgatc caactgcctc ggcctcccaa agtgctggga ttacaggtat gagccaccgt   1920

gcccagcaga attttttaac tatttggtta cgactaattt ggataatgta gtgcatgcag   1980

ctttgatttg tgccactaag agtgggcaaa ctgtcttcct ttttgtgaat cagtaaaaat   2040

tttccctcaa catgtgtttg acagttgtca ttcactgcta agttaaggca tttggtaaac   2100

cacacagcct ctgcatcctt cctagcgaca gccacaagaa aaggtgggca tgggagggaa   2160

aatgctcttg tgaattgaac tggaggcaag ctccactttt ctttagaaaa agatgtagat   2220

caaaataact aatattttct tccttgctcg atttctgtgc cttccatggt acatcaaaat   2280

aataggacca gtaatggcca caatcctgtt gactgctgtt accttcgccc caatatttct   2340

ttaagcattt cttaagcatc tagcttgtgt tttgttatat ttaacagatt ttcttaaagt   2400

attgtatgaa ttaaaaccag aaataacttc attttcctag aaagggataa tttctcccgg   2460

agaataaatc ctgaggattt agttagatgc tgtgggtatt gtattttaaa taatatttta   2520

atgggagcag ctgattgact ttcaaatgga ttgtttacat taatagtaat tctgcagttg   2580

ttttactatt gcatcagtct gccagacaag ttccatgtgc atattttaat tcagaactaa   2640

ttatacttaa aaatttaaac cctgcatact tccccaaaaa tgtttagggc agttaaaaac   2700

aactcttttg gaagatgact cgcattttaa gaaatgagag aacactgtca aatgatgaat   2760

gcatttaaaa aataatttgc aaagtgataa aagcccttag ttttaaatct tacaatgaca   2820

ttagctctta caagaactca gtaagtattt gctgtttttt aatgggatag taataaggtt   2880

gaggtttttg ttaagggacg tttacttatc atcaaactct atacttacta ctacaaggaa   2940

actccaagta cattaaacac tatgttttat aattctttgc cacactgcca ataaattctg   3000

ttcacatttt aaggatgaca agtccactat atgtaacacg taagaatgct atcctggcag   3060

tagacacagg gccagaataa actggcaagt tttcattcca cacaagtgtg ggaaaaaaat   3120

gactacaact taaactttat ttacttgatt gagagcttat tgcacatgaa atgttttatg   3180

tggttgatct taacttcgtt tacattgact tctatgctca agattgttca attgctgctg   3240

ctgccgttgt gttttctttc aggatcgagg tgggtacctt catataatat cttcttttta   3300

atttcttctc tggcaattct ttcctggatt ctttgctttg cataattata cctacaatga   3360

aaccttagaa gaaaagaata tgaataaatt gttaatataa agtcctacag aaattaattt   3420

atgaaatttc tctaaatcac acaaaactta aatacagatg actactaccc tgagactgaa   3480

aaatatgttc taatttatag tgctattttt gggcagtttt ggtgtcagaa tacctatcaa   3540

cacattcttt ttttattagg aaaaaaagga tgtctacata acaatttgta aagtgataaa   3600

atccattagt ttttaagtct tctgatagca ttggctatta taagaaacaa gtatttgctc   3660

tcgtttttaa cgggataata atgctatgtc tacataaaat gatttctacc accttaaata   3720

gctcactgta gaaattcatg tataaatgga accatatagt acatacatat catactctta   3780

ggtctggcaa atatttgagg ttcatccata ttttatattc actcatcagt agttgtaaac   3840

acattcttaa agtagcattt tcagatatga ataagcaggg atgaaataag tattagggta   3900

agggaaatgg ttgaggcttt cctaagtgaa gtgtaaaaac cacagctttc tttttaatgg   3960

gatgtctaat atgcatttat ctgttcaagc attttaagat ttccatgaaa atgtcctgaa   4020

aaatcaagat tcttcattga gggtgaggat ctcccaatgg gagactgctc tgaaaagagc   4080

atgtgctttt tgaattagat aacctactat aatcatggat gttcttgaat acttagcaaa   4140

cataccagca tcccaaagtc accaagataa accctcctac tccaacatca catgatcttc   4200

taattctacc tgtaaaaata agcataacaa ttaattagaa tataattacg ttatatacat   4260

tactccacct agaaaaaaaa atagttcatt atgtagagaa atgctttttt tagtacatag   4320

agaaataaaa aatacagata ctcactagtg aacaaaaaat gtccaaagcc agccacaaca   4380

gatcctaatg aaccatacaa tattgaatgc cgggcgcagg gagtattttc aacatctaaa   4440

aatcctagga gcttaaggga ctagaatgaa aaaaaagaac ctagattgag taagaaagta   4500

tttcattttg gggtgctttg gcaaaaatga caatacacca tttcttttct tgtagttgag   4560

ggtttaaact agagtatgtg ccacgtgaca acctaaatca gcttgcgttg tctttgtcca   4620

cctttggtat gcagtctgaa tctttaaatc cgaaaacctt acaaattgga ccggaaaacc   4680

cttaagcagt agggtaactt ggagctgtat cttaatttgc taatcaactg acttggaaat   4740

aggataattc attttatgag ctctttaaat gagtttattt gggaatatgc ctatcattgg   4800

aattgaaagc agcatagctt gcttcagtaa ctccaataat ttgggaagca gaaatggaaa   4860

aagtaatttg agtcatgttt gcttatgtag tgccgtttaa aattccccta gtaattacct   4920

ttcatatttt attaactagg ttaacatcaa ctgtggttgt aagagtaaat gtttcacctt   4980

aagataaaca tgggcaatat attaaactct agtctgtttt cttgcctgtg aagtgaggct   5040

gcacttgatt atatttgatt ctttgttcgt aatacatggg aacgacagct aagtgtggtg   5100

aaaaacgcgg ggatccaaag agctggattt ttatctcaga tctgccgcta acttttgtat   5160

cctataggct acttttattt ctatggtctc aatctataac atgaatgggt tgggttaaat   5220

gactgaagtt ccttcaagtg ctaaaattct ttttctacag tcttcattgg atttatgtat   5280

ttcttattcc taatatgttt aactgggatg tctgtcactc tagggcggca agacagacat   5340

ttaaaagtaa cagtcacact gctgaactgg catttctgtt aacacaaaag tttagaaaac   5400

tcacggtaac tgttacttga tttaagtgta tataaaattt tcagtaaggc tgcttttaaa   5460

aggaaccact gtccatttaa aggtttcata gttatcttca atgggttagt attgtttggg   5520

gcaggacatt aaactagaag ggattctata ggatgaggtg atacctagaa ggtaatatat   5580

tgtaaggcaa aagagattag aagaaatggg gaaaggatag taaaaggcaa gtcagattaa   5640

aggttgaaac atgaagatat tctcaattgt atttctgcct atgtttgctt ttttggctca   5700

agcatctgtt ggaagagaca aaatgtgact tggttcataa taaagcaaga attatttact   5760

ctcggatcat tctattccat tttttccctc tgtctggccc cgttcccacc cgcatgccta   5820

acataggatt gcttcaaagc tttgcagtac agttcttcac attaccaaga ggttggggga   5880

tttcatttag caagacgact ttttcctatc agcttgagag cccaggggac atatgatcat   5940

gtgggtag                                                            5948


<210>  2073
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  2073

Met Lys Glu Ala Val His Trp Arg Phe Gln Val Val Met Glu Gly Phe 
1               5                   10                  15


Gln Phe Met Gln Thr Ser Val Lys Met Ser Phe Val Ile Gly Glu Asp 
            20                  25                  30


Ile Gly Asn Phe Thr Ser Gln Asn Arg Val Ser Leu Leu Phe Arg Val 
        35                  40                  45


Arg Cys Asn Cys Ser Val Leu Ala Leu Glu Gly Thr Cys Phe Ile Cys 
    50                  55                  60


Tyr Val Cys Tyr Thr Ser Ala Leu His Val Leu Gln Phe Cys Ile Leu 
65                  70                  75                  80


Gly Phe Asn Gln Leu Trp Val Glu Asn Thr Gly Gly Lys Lys Thr Lys 
                85                  90                  95


Asn Asn Asn Glu Glu Gln Gln Gln Lys Tyr Thr Val 
            100                 105


<210>  2074
<211>  5770
<212>  DNA
<213>  Homo sapiens

<400>  2074
aacaatcgtg gctacaaaaa tcaatctcag ggctacaacc agtggcagca gggtgtaagt     60

aatttcttat gtgctttatg tacattaatt gtattttgag ttcctaagat ttatcagtct    120

tgaaaaagat cttgttcagg gattgaagtg tttataagtg ttaatagggt aaagtgtgaa    180

tcgtcttgca gtagtagcca taatctacct tttgaaggca aaataggttg aagattgcta    240

taagttaaat ttttttaata aagtaatatt atttaatata tacagttctt ttactgctag    300

ctttaattgt gtaaactaac aaagtcatga tgtttcgttt tgtaatgtgt attgataatt    360

atgggatatt aaaactaaat ctggtttggt agaaatcaga ggtatgacag gtataaattt    420

gtttccagca aattactctg aattagattc attgtcattt cctaaaaaca gtttgagtgg    480

cttattgatg ttttttcttt aaaaacaaaa ttttctctta cagcaattct ggggtcagaa    540

gccatggagt cagcattatc accaaggata ttattgaata cccaaataaa acgaactgat    600

acatatttct ccaaaacctt cacaagaagt cgactgtttt ctttagtagg ctaacttttt    660

aaacattcca caagaggaag tgcctgcggg ttcctttttt agaagctttt ctgtccatgt    720

gaatgtgctg tgtggaagag ttaaagggcc caactaaatg ttccagtgat tccaatagct    780

atttagctgg tacctactgc tatatcacct agtgtgacat ttcggaatta atggaacaat    840

gaaggaagct gtacactgga ggttccaggt ggtcatggaa ggtttccagt ttatgcaaac    900

ttctgtgaaa atgagctttg ttattggtga agacattgga aattttacca gccaaaacag    960

agtttctctc ttattcaggg taagatgtaa ttgcagtgtg ctagcgctgg aagggacctg   1020

ttttatatgt tatgtatgtt acacgtcagc cctccatgtc ctccagttct gcatccttgg   1080

attcaaccaa ctgtgggttg aaaatactgg aggtaaaaag acaaaaaata acaatgaaga   1140

acaacaacaa aaatacacag tataataatt acatttacat agcatttatt ttgtattaga   1200

cattataagt aatctagaga tgatttaaag tatatgggag aatgtatgta gattatatgg   1260

aaatatgagg gtattttatt taaagggact tgggcctgtg gataccaagg aataactaag   1320

gtaaaactga gcataagtgg cctgtccata ttttgttaaa tatcagatta ttgattagtg   1380

atcatcaaca ttttcccgca ttcatgcagt gcggcctctg aaaacatggt tgaacatcct   1440

atggaatttt tttttttttt tgagatggag tctcactctg tcacctaggc tagagtgcaa   1500

tggcgcgatc ttggcttact gcaacctccg cctgccccac ctcgggttca agtgattctc   1560

ctgcctcagc ctcctgagta cctgggacta caggcatgca ccaccacgcc cggctaattt   1620

ttgtattttt agacgagaca gggtttcacc ctgttggcca ggctggtctc aaactcctaa   1680

cctcaggtga tccaactgcc tcggcctccc aaagtgctgg gattacaggt atgagccacc   1740

gtgcccagca gaatttttta actatttggt tacgactaat ttggataatg tagtgcatgc   1800

agctttgatt tgtgccacta agagtgggca aactgtcttc ctttttgtga atcagtaaaa   1860

attttccctc aacatgtgtt tgacagttgt cattcactgc taagttaagg catttggtaa   1920

accacacagc ctctgcatcc ttcctagcga cagccacaag aaaaggtggg catgggaggg   1980

aaaatgctct tgtgaattga actggaggca agctccactt ttctttagaa aaagatgtag   2040

atcaaaataa ctaatatttt cttccttgct cgatttctgt gccttccatg gtacatcaaa   2100

ataataggac cagtaatggc cacaatcctg ttgactgctg ttaccttcgc cccaatattt   2160

ctttaagcat ttcttaagca tctagcttgt gttttgttat atttaacaga ttttcttaaa   2220

gtattgtatg aattaaaacc agaaataact tcattttcct agaaagggat aatttctccc   2280

ggagaataaa tcctgaggat ttagttagat gctgtgggta ttgtatttta aataatattt   2340

taatgggagc agctgattga ctttcaaatg gattgtttac attaatagta attctgcagt   2400

tgttttacta ttgcatcagt ctgccagaca agttccatgt gcatatttta attcagaact   2460

aattatactt aaaaatttaa accctgcata cttccccaaa aatgtttagg gcagttaaaa   2520

acaactcttt tggaagatga ctcgcatttt aagaaatgag agaacactgt caaatgatga   2580

atgcatttaa aaaataattt gcaaagtgat aaaagccctt agttttaaat cttacaatga   2640

cattagctct tacaagaact cagtaagtat ttgctgtttt ttaatgggat agtaataagg   2700

ttgaggtttt tgttaaggga cgtttactta tcatcaaact ctatacttac tactacaagg   2760

aaactccaag tacattaaac actatgtttt ataattcttt gccacactgc caataaattc   2820

tgttcacatt ttaaggatga caagtccact atatgtaaca cgtaagaatg ctatcctggc   2880

agtagacaca gggccagaat aaactggcaa gttttcattc cacacaagtg tgggaaaaaa   2940

atgactacaa cttaaacttt atttacttga ttgagagctt attgcacatg aaatgtttta   3000

tgtggttgat cttaacttcg tttacattga cttctatgct caagattgtt caattgctgc   3060

tgctgccgtt gtgttttctt tcaggatcga ggtgggtacc ttcatataat atcttctttt   3120

taatttcttc tctggcaatt ctttcctgga ttctttgctt tgcataatta tacctacaat   3180

gaaaccttag aagaaaagaa tatgaataaa ttgttaatat aaagtcctac agaaattaat   3240

ttatgaaatt tctctaaatc acacaaaact taaatacaga tgactactac cctgagactg   3300

aaaaatatgt tctaatttat agtgctattt ttgggcagtt ttggtgtcag aatacctatc   3360

aacacattct ttttttatta ggaaaaaaag gatgtctaca taacaatttg taaagtgata   3420

aaatccatta gtttttaagt cttctgatag cattggctat tataagaaac aagtatttgc   3480

tctcgttttt aacgggataa taatgctatg tctacataaa atgatttcta ccaccttaaa   3540

tagctcactg tagaaattca tgtataaatg gaaccatata gtacatacat atcatactct   3600

taggtctggc aaatatttga ggttcatcca tattttatat tcactcatca gtagttgtaa   3660

acacattctt aaagtagcat tttcagatat gaataagcag ggatgaaata agtattaggg   3720

taagggaaat ggttgaggct ttcctaagtg aagtgtaaaa accacagctt tctttttaat   3780

gggatgtcta atatgcattt atctgttcaa gcattttaag atttccatga aaatgtcctg   3840

aaaaatcaag attcttcatt gagggtgagg atctcccaat gggagactgc tctgaaaaga   3900

gcatgtgctt tttgaattag ataacctact ataatcatgg atgttcttga atacttagca   3960

aacataccag catcccaaag tcaccaagat aaaccctcct actccaacat cacatgatct   4020

tctaattcta cctgtaaaaa taagcataac aattaattag aatataatta cgttatatac   4080

attactccac ctagaaaaaa aaatagttca ttatgtagag aaatgctttt tttagtacat   4140

agagaaataa aaaatacaga tactcactag tgaacaaaaa atgtccaaag ccagccacaa   4200

cagatcctaa tgaaccatac aatattgaat gccgggcgca gggagtattt tcaacatcta   4260

aaaatcctag gagcttaagg gactagaatg aaaaaaaaga acctagattg agtaagaaag   4320

tatttcattt tggggtgctt tggcaaaaat gacaatacac catttctttt cttgtagttg   4380

agggtttaaa ctagagtatg tgccacgtga caacctaaat cagcttgcgt tgtctttgtc   4440

cacctttggt atgcagtctg aatctttaaa tccgaaaacc ttacaaattg gaccggaaaa   4500

cccttaagca gtagggtaac ttggagctgt atcttaattt gctaatcaac tgacttggaa   4560

ataggataat tcattttatg agctctttaa atgagtttat ttgggaatat gcctatcatt   4620

ggaattgaaa gcagcatagc ttgcttcagt aactccaata atttgggaag cagaaatgga   4680

aaaagtaatt tgagtcatgt ttgcttatgt agtgccgttt aaaattcccc tagtaattac   4740

ctttcatatt ttattaacta ggttaacatc aactgtggtt gtaagagtaa atgtttcacc   4800

ttaagataaa catgggcaat atattaaact ctagtctgtt ttcttgcctg tgaagtgagg   4860

ctgcacttga ttatatttga ttctttgttc gtaatacatg ggaacgacag ctaagtgtgg   4920

tgaaaaacgc ggggatccaa agagctggat ttttatctca gatctgccgc taacttttgt   4980

atcctatagg ctacttttat ttctatggtc tcaatctata acatgaatgg gttgggttaa   5040

atgactgaag ttccttcaag tgctaaaatt ctttttctac agtcttcatt ggatttatgt   5100

atttcttatt cctaatatgt ttaactggga tgtctgtcac tctagggcgg caagacagac   5160

atttaaaagt aacagtcaca ctgctgaact ggcatttctg ttaacacaaa agtttagaaa   5220

actcacggta actgttactt gatttaagtg tatataaaat tttcagtaag gctgctttta   5280

aaaggaacca ctgtccattt aaaggtttca tagttatctt caatgggtta gtattgtttg   5340

gggcaggaca ttaaactaga agggattcta taggatgagg tgatacctag aaggtaatat   5400

attgtaaggc aaaagagatt agaagaaatg gggaaaggat agtaaaaggc aagtcagatt   5460

aaaggttgaa acatgaagat attctcaatt gtatttctgc ctatgtttgc ttttttggct   5520

caagcatctg ttggaagaga caaaatgtga cttggttcat aataaagcaa gaattattta   5580

ctctcggatc attctattcc attttttccc tctgtctggc cccgttccca cccgcatgcc   5640

taacatagga ttgcttcaaa gctttgcagt acagttcttc acattaccaa gaggttgggg   5700

gatttcattt agcaagacga ctttttccta tcagcttgag agcccagggg acatatgatc   5760

atgtgggtag                                                          5770


<210>  2075
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  2075

Met Lys Glu Ala Val His Trp Arg Phe Gln Val Val Met Glu Gly Phe 
1               5                   10                  15


Gln Phe Met Gln Thr Ser Val Lys Met Ser Phe Val Ile Gly Glu Asp 
            20                  25                  30


Ile Gly Asn Phe Thr Ser Gln Asn Arg Val Ser Leu Leu Phe Arg Val 
        35                  40                  45


Arg Cys Asn Cys Ser Val Leu Ala Leu Glu Gly Thr Cys Phe Ile Cys 
    50                  55                  60


Tyr Val Cys Tyr Thr Ser Ala Leu His Val Leu Gln Phe Cys Ile Leu 
65                  70                  75                  80


Gly Phe Asn Gln Leu Trp Val Glu Asn Thr Gly Gly Lys Lys Thr Lys 
                85                  90                  95


Asn Asn Asn Glu Glu Gln Gln Gln Lys Tyr Thr Val 
            100                 105


<210>  2076
<211>  2030
<212>  DNA
<213>  Homo sapiens

<400>  2076
gaaaaaatgg aatagaatga tccgagagta aataattctt gctttattat gaaccaagtc     60

acattttgtc tcttccaaca gatgcttgag ccaaaaaagc aaacataggc agaaatacaa    120

ttgagaatat cttcatgttt caacctttaa tctgacttgc cttttactat cctttcccca    180

tttcttctaa tctcttttgc cttacaatat attaccttct aggtatcacc tcatcctata    240

gaatcccttc tagtttaatg tcctgcccca aacaatacta acccattgaa gataactatg    300

aaacctttaa atggacagtg gttcctttta aaagcagcct tactgaaaat tttatataca    360

cttaaatcaa gtaacagtta ccgtgagttt tctaaacttt tgtgttaaca gaaatgccag    420

ttcagcagtg tgactgttac ttttaaatgt ctgtcttgcc gccctagagt gacagacatc    480

ccagttaaac atattaggaa taagaaatac ataaatccaa tgaagactgt agaaaaagaa    540

ttttagcact tgaaggaact tcagtcattt aacccaaccc attcatgtta tagattgaga    600

ccatagaaat aaaagtagcc tataggatac aaaagttagc ggcagatctg agataaaaat    660

ccagctcttt ggatccccgc gtttttcacc acacttagct gtcgttccca tgtattacga    720

acaaagaatc aaatataatc aagtgcagcc tcacttcaca ggcaagaaaa cagactagag    780

tttaatatat tgcccatgtt tatcttaagg tgaaacattt actcttacaa ccacagttga    840

tgttaaccta gttaataaaa tatgaaaggt aattactagg ggaattttaa acggcactac    900

ataagcaaac atgactcaaa ttactttttc catttctgct tcccaaatta ttggagttac    960

tgaagcaagc tatgctgctt tcaattccaa tgataggcat attcccaaat aaactcattt   1020

aaagagctca taaaatgaat tatcctattt ccaagtcagt tgattagcaa attaagatac   1080

agctccaagt taccctactg cttaagggtt ttccggtcca atttgtaagg ttttcggatt   1140

taaagattca gactgcatac caaaggtgga caaagacaac gcaagctgat ttaggttgtc   1200

acgtggcaca tactctagtt taaaccctca actacaagaa aagaaatggt gtattgtcat   1260

ttttgccaaa gcaccccaaa atgaaatact ttcttactca atctaggttc ttttttttca   1320

ttctagtccc ttaagctcct aggattttta gatgttgaaa atactccctg cgcccggcat   1380

tcaatattgt atggttcatt aggatctgtt gtggctggct ttggacattt tttgttcact   1440

agtagaatta gaagatcatg tgatgttgga gtaggagggt ttatcttggt gactttggga   1500

tgctggtttc attgtaggta taattatgca aagcaaagaa tccaggaaag aattgccaga   1560

gaagaaatta aaaagaagat attatatgaa ggtacccacc tcgatcctga aagaaaacac   1620

aacggcagca gcagcaattg aacaatcttg agcatagaag tcaatgtaaa cgaagttaag   1680

atcaaccaca taaaacattt catgtgcaat aagctctcaa tcaagtaaat aaagtttaag   1740

ttgtagtcat ttttttccca cacttgtgtg gaatgaaaac ttgccagttt attctggccc   1800

tgtgtctact gccaggatag cattcttacg tgttacatat agtggacttg tcatccttaa   1860

aatgtgaaca gaatttattg gcagtgtggc aaagaattat aaaacatagt gtttaatgta   1920

cttggagttt ccttgtagta gtaagtatag agtttgatga taagtaaacg tcccttaaca   1980

aaaacctcaa ccttattact atcccattaa aaaacagcaa atacttactg              2030


<210>  2077
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  2077

Met Gln Ser Lys Glu Ser Arg Lys Glu Leu Pro Glu Lys Lys Leu Lys 
1               5                   10                  15


Arg Arg Tyr Tyr Met Lys Val Pro Thr Ser Ile Leu Lys Glu Asn Thr 
            20                  25                  30


Thr Ala Ala Ala Ala Ile Glu Gln Ser 
        35                  40


<210>  2078
<211>  3520
<212>  DNA
<213>  Homo sapiens

<400>  2078
gaaaaaatgg aatagaatga tccgagagta aataattctt gctttattat gaaccaagtc     60

acattttgtc tcttccaaca gatgcttgag ccaaaaaagc aaacataggc agaaatacaa    120

ttgagaatat cttcatgttt caacctttaa tctgacttgc cttttactat cctttcccca    180

tttcttctaa tctcttttgc cttacaatat attaccttct aggtatcacc tcatcctata    240

gaatcccttc tagtttaatg tcctgcccca aacaatacta acccattgaa gataactatg    300

aaacctttaa atggacagtg gttcctttta aaagcagcct tactgaaaat tttatataca    360

cttaaatcaa gtaacagtta ccgtgagttt tctaaacttt tgtgttaaca gaaatgccag    420

ttcagcagtg tgactgttac ttttaaatgt ctgtcttgcc gccctagagt gacagacatc    480

ccagttaaac atattaggaa taagaaatac ataaatccaa tgaagactgt agaaaaagaa    540

ttttagcact tgaaggaact tcagtcattt aacccaaccc attcatgtta tagattgaga    600

ccatagaaat aaaagtagcc tataggatac aaaagttagc ggcagatctg agataaaaat    660

ccagctcttt ggatccccgc gtttttcacc acacttagct gtcgttccca tgtattacga    720

acaaagaatc aaatataatc aagtgcagcc tcacttcaca ggcaagaaaa cagactagag    780

tttaatatat tgcccatgtt tatcttaagg tgaaacattt actcttacaa ccacagttga    840

tgttaaccta gttaataaaa tatgaaaggt aattactagg ggaattttaa acggcactac    900

ataagcaaac atgactcaaa ttactttttc catttctgct tcccaaatta ttggagttac    960

tgaagcaagc tatgctgctt tcaattccaa tgataggcat attcccaaat aaactcattt   1020

aaagagctca taaaatgaat tatcctattt ccaagtcagt tgattagcaa attaagatac   1080

agctccaagt taccctactg cttaagggtt ttccggtcca atttgtaagg ttttcggatt   1140

taaagattca gactgcatac caaaggtgga caaagacaac gcaagctgat ttaggttgtc   1200

acgtggcaca tactctagtt taaaccctca actacaagaa aagaaatggt gtattgtcat   1260

ttttgccaaa gcaccccaaa atgaaatact ttcttactca atctaggttc ttttttttca   1320

ttctagtccc ttaagctcct aggattttta gatgttgaaa atactccctg cgcccggcat   1380

tcaatattgt atggttcatt aggatctgtt gtggctggct ttggacattt tttgttcact   1440

agtagaatta gaagatcatg tgatgttgga gtaggagggt ttatcttggt gactttggga   1500

tgctggtttc attgtaggta taattatgca aagcaaagaa tccaggaaag aattgccaga   1560

gaagaaatta aaaagaagat attatatgaa ggtacccacc tcgatcctga aagaaaacac   1620

aacggcagca gcagcaattg aacaatcttg agcatagaag tcaatgtaaa cgaagttaag   1680

atcaaccaca taaaacattt catgtgcaat aagctctcaa tcaagtaaat aaagtttaag   1740

ttgtagtcat ttttttccca cacttgtgtg gaatgaaaac ttgccagttt attctggccc   1800

tgtgtctact gccaggatag cattcttacg tgttacatat agtggacttg tcatccttaa   1860

aatgtgaaca gaatttattg gcagtgtggc aaagaattat aaaacatagt gtttaatgta   1920

cttggagttt ccttgtagta gtaagtatag agtttgatga taagtaaacg tcccttaaca   1980

aaaacctcaa ccttattact atcccattaa aaaacagcaa atacttactg agttcttgta   2040

agagctaatg tcattgtaag atttaaaact aagggctttt atcactttgc aaattatttt   2100

ttaaatgcat tcatcatttg acagtgttct ctcatttctt aaaatgcgag tcatcttcca   2160

aaagagttgt ttttaactgc cctaaacatt tttggggaag tatgcagggt ttaaattttt   2220

aagtataatt agttctgaat taaaatatgc acatggaact tgtctggcag actgatgcaa   2280

tagtaaaaca actgcagaat tactattaat gtaaacaatc catttgaaag tcaatcagct   2340

gctcccatta aaatattatt taaaatacaa tacccacagc atctaactaa atcctcagga   2400

tttattctcc gggagaaatt atccctttct aggaaaatga agttatttct ggttttaatt   2460

catacaatac tttaagaaaa tctgttaaat ataacaaaac acaagctaga tgcttaagaa   2520

atgcttaaag aaatattggg gcgaaggtaa cagcagtcaa caggattgtg gccattactg   2580

gtcctattat tttgatgtac catggaaggc acagaaatcg agcaaggaag aaaatattag   2640

ttattttgat ctacatcttt ttctaaagaa aagtggagct tgcctccagt tcaattcaca   2700

agagcatttt ccctcccatg cccacctttt cttgtggctg tcgctaggaa ggatgcagag   2760

gctgtgtggt ttaccaaatg ccttaactta gcagtgaatg acaactgtca aacacatgtt   2820

gagggaaaat ttttactgat tcacaaaaag gaagacagtt tgcccactct tagtggcaca   2880

aatcaaagct gcatgcacta cattatccaa attagtcgta accaaatagt taaaaaattc   2940

tgctgggcac ggtggctcat acctgtaatc ccagcacttt gggaggccga ggcagttgga   3000

tcacctgagg ttaggagttt gagaccagcc tggccaacag ggtgaaaccc tgtctcgtct   3060

aaaaatacaa aaattagccg ggcgtggtgg tgcatgcctg tagtcccagg tactcaggag   3120

gctgaggcag gagaatcact tgaacccgag gtggggcagg cggaggttgc agtaagccaa   3180

gatcgcgcca ttgcactcta gcctaggtga cagagtgaga ctccatctca aaaaaaaaaa   3240

aaaattccat aggatgttca accatgtttt cagaggccgc actgcatgaa tgcgggaaaa   3300

tgttgatgat cactaatcaa taatctgata tttaacaaaa tatggacagg ccacttatgc   3360

tcagttttac cttagttatt ccttggtatc cacaggccca agtcccttta aataaaatac   3420

cctcatattt ccatataatc tacatacatt ctcccatata ctttaaatca tctctagatt   3480

acttataatg tctaatacaa aataaatgct atgtaaatgt                         3520


<210>  2079
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  2079

Met Leu Lys Lys Cys Leu Lys Lys Tyr Trp Gly Glu Gly Asn Ser Ser 
1               5                   10                  15


Gln Gln Asp Cys Gly His Tyr Trp Ser Tyr Tyr Phe Asp Val Pro Trp 
            20                  25                  30


Lys Ala Gln Lys Ser Ser Lys Glu Glu Asn Ile Ser Tyr Phe Asp Leu 
        35                  40                  45


His Leu Phe Leu Lys Lys Ser Gly Ala Cys Leu Gln Phe Asn Ser Gln 
    50                  55                  60


Glu His Phe Pro Ser His Ala His Leu Phe Leu Trp Leu Ser Leu Gly 
65                  70                  75                  80


Arg Met Gln Arg Leu Cys Gly Leu Pro Asn Ala Leu Thr 
                85                  90


<210>  2080
<211>  3835
<212>  DNA
<213>  Homo sapiens

<400>  2080
gaaaaaatgg aatagaatga tccgagagta aataattctt gctttattat gaaccaagtc     60

acattttgtc tcttccaaca gatgcttgag ccaaaaaagc aaacataggc agaaatacaa    120

ttgagaatat cttcatgttt caacctttaa tctgacttgc cttttactat cctttcccca    180

tttcttctaa tctcttttgc cttacaatat attaccttct aggtatcacc tcatcctata    240

gaatcccttc tagtttaatg tcctgcccca aacaatacta acccattgaa gataactatg    300

aaacctttaa atggacagtg gttcctttta aaagcagcct tactgaaaat tttatataca    360

cttaaatcaa gtaacagtta ccgtgagttt tctaaacttt tgtgttaaca gaaatgccag    420

ttcagcagtg tgactgttac ttttaaatgt ctgtcttgcc gccctagagt gacagacatc    480

ccagttaaac atattaggaa taagaaatac ataaatccaa tgaagactgt agaaaaagaa    540

ttttagcact tgaaggaact tcagtcattt aacccaaccc attcatgtta tagattgaga    600

ccatagaaat aaaagtagcc tataggatac aaaagttagc ggcagatctg agataaaaat    660

ccagctcttt ggatccccgc gtttttcacc acacttagct gtcgttccca tgtattacga    720

acaaagaatc aaatataatc aagtgcagcc tcacttcaca ggcaagaaaa cagactagag    780

tttaatatat tgcccatgtt tatcttaagg tgaaacattt actcttacaa ccacagttga    840

tgttaaccta gttaataaaa tatgaaaggt aattactagg ggaattttaa acggcactac    900

ataagcaaac atgactcaaa ttactttttc catttctgct tcccaaatta ttggagttac    960

tgaagcaagc tatgctgctt tcaattccaa tgataggcat attcccaaat aaactcattt   1020

aaagagctca taaaatgaat tatcctattt ccaagtcagt tgattagcaa attaagatac   1080

agctccaagt taccctactg cttaagggtt ttccggtcca atttgtaagg ttttcggatt   1140

taaagattca gactgcatac caaaggtgga caaagacaac gcaagctgat ttaggttgtc   1200

acgtggcaca tactctagtt taaaccctca actacaagaa aagaaatggt gtattgtcat   1260

ttttgccaaa gcaccccaaa atgaaatact ttcttactca atctaggttc ttttttttca   1320

ttctagtccc ttaagctcct aggattttta gatgttgaaa atactccctg cgcccggcat   1380

tcaatattgt atggttcatt aggatctgtt gtggctggct ttggacattt tttgttcact   1440

agtagaatta gaagatcatg tgatgttgga gtaggagggt ttatcttggt gactttggga   1500

tgctggtttc attgtaggta taattatgca aagcaaagaa tccaggaaag aattgccaga   1560

gaagaaatta aaaagaagat attatatgaa ggtacccacc tcgatcctga aagaaaacac   1620

aacggcagca gcagcaattg aacaatcttg agcatagaag tcaatgtaaa cgaagttaag   1680

atcaaccaca taaaacattt catgtgcaat aagctctcaa tcaagtaaat aaagtttaag   1740

ttgtagtcat ttttttccca cacttgtgtg gaatgaaaac ttgccagttt attctggccc   1800

tgtgtctact gccaggatag cattcttacg tgttacatat agtggacttg tcatccttaa   1860

aatgtgaaca gaatttattg gcagtgtggc aaagaattat aaaacatagt gtttaatgta   1920

cttggagttt ccttgtagta gtaagtatag agtttgatga taagtaaacg tcccttaaca   1980

aaaacctcaa ccttattact atcccattaa aaaacagcaa atacttactg agttcttgta   2040

agagctaatg tcattgtaag atttaaaact aagggctttt atcactttgc aaattatttt   2100

ttaaatgcat tcatcatttg acagtgttct ctcatttctt aaaatgcgag tcatcttcca   2160

aaagagttgt ttttaactgc cctaaacatt tttggggaag tatgcagggt ttaaattttt   2220

aagtataatt agttctgaat taaaatatgc acatggaact tgtctggcag actgatgcaa   2280

tagtaaaaca actgcagaat tactattaat gtaaacaatc catttgaaag tcaatcagct   2340

gctcccatta aaatattatt taaaatacaa tacccacagc atctaactaa atcctcagga   2400

tttattctcc gggagaaatt atccctttct aggaaaatga agttatttct ggttttaatt   2460

catacaatac tttaagaaaa tctgttaaat ataacaaaac acaagctaga tgcttaagaa   2520

atgcttaaag aaatattggg gcgaaggtaa cagcagtcaa caggattgtg gccattactg   2580

gtcctattat tttgatgtac catggaaggc acagaaatcg agcaaggaag aaaatattag   2640

ttattttgat ctacatcttt ttctaaagaa aagtggagct tgcctccagt tcaattcaca   2700

agagcatttt ccctcccatg cccacctttt cttgtggctg tcgctaggaa ggatgcagag   2760

gctgtgtggt ttaccaaatg ccttaactta gcagtgaatg acaactgtca aacacatgtt   2820

gagggaaaat ttttactgat tcacaaaaag gaagacagtt tgcccactct tagtggcaca   2880

aatcaaagct gcatgcacta cattatccaa attagtcgta accaaatagt taaaaaattc   2940

tgctgggcac ggtggctcat acctgtaatc ccagcacttt gggaggccga ggcagttgga   3000

tcacctgagg ttaggagttt gagaccagcc tggccaacag ggtgaaaccc tgtctcgtct   3060

aaaaatacaa aaattagccg ggcgtggtgg tgcatgcctg tagtcccagg tactcaggag   3120

gctgaggcag gagaatcact tgaacccgag gtggggcagg cggaggttgc agtaagccaa   3180

gatcgcgcca ttgcactcta gcctaggtga cagagtgaga ctccatctca aaaaaaaaaa   3240

aaaattccat aggatgttca accatgtttt cagaggccgc actgcatgaa tgcgggaaaa   3300

tgttgatgat cactaatcaa taatctgata tttaacaaaa tatggacagg ccacttatgc   3360

tcagttttac cttagttatt ccttggtatc cacaggccca agtcccttta aataaaatac   3420

cctcatattt ccatataatc tacatacatt ctcccatata ctttaaatca tctctagatt   3480

acttataatg tctaatacaa aataaatgct atgtaaatgt aattattata ctgtgtattt   3540

ttgttgttgt tcttcattgt tattttttgt ctttttacct ccagtatttt caacccacag   3600

ttggttgaat ccaaggatgc agaactggag gacatggagg gctgacgtgt aacatacata   3660

acatataaaa caggtccctt ccagcgctag cacactgcaa ttacatctta ccctgaataa   3720

gagagaaact ctgttttggc tggtaaaatt tccaatgtct tcaccaataa caaagctcat   3780

tttcacagaa gtttgcataa actggaaacc tggataaaaa caaagttgta acata        3835


<210>  2081
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  2081

Met Leu Lys Lys Cys Leu Lys Lys Tyr Trp Gly Glu Gly Asn Ser Ser 
1               5                   10                  15


Gln Gln Asp Cys Gly His Tyr Trp Ser Tyr Tyr Phe Asp Val Pro Trp 
            20                  25                  30


Lys Ala Gln Lys Ser Ser Lys Glu Glu Asn Ile Ser Tyr Phe Asp Leu 
        35                  40                  45


His Leu Phe Leu Lys Lys Ser Gly Ala Cys Leu Gln Phe Asn Ser Gln 
    50                  55                  60


Glu His Phe Pro Ser His Ala His Leu Phe Leu Trp Leu Ser Leu Gly 
65                  70                  75                  80


Arg Met Gln Arg Leu Cys Gly Leu Pro Asn Ala Leu Thr 
                85                  90


<210>  2082
<211>  5765
<212>  DNA
<213>  Homo sapiens

<400>  2082
ctctctcaga attagtattt gcctattaat gtaatcagtg tagccttctc aacataaaaa     60

tgtccttatt ctagaacatg gaagcgtacg gcaaatgcaa cggttgaaag cactgaaaaa    120

tatttgtaaa acatctgtag tgctcacatt atgaacttta aatgtaatac tttgaaaacc    180

atcttcataa tttttttgtt ctaacagctt cctttttaag aaaacatttt aaaacatttt    240

aaaatggaac ttaatgtgca aaataagttg tgtaaaatac cagtatttgg gtggtggagg    300

atattggtat attatattga cctgggttga tgactactgg actattttaa gatacctact    360

tccaaaactt attttattct agaggaccac taaaaatcag aattacagca atcattttaa    420

tttttctact ttccttgtta aggtcttctg cttacccaaa gaatagtgta tatcttaaca    480

tgacttttaa aggggtatct tgatccccat cacagatttt tatctatgaa tagaaggatt    540

gaaaccctat ttgatcccta gctctttgct gaaaagtgca taaacaggaa tcctgaattt    600

attatataga cctcctcgca ttatataatc gaagcaaagg gaaaccagcg atggagtaga    660

ggtacgtaga ctaaagagat gcttgcaaat gatggtacct agggatagtc acattttctt    720

gttgccaaac tcagacaata taatcacaag tccagagaag agctagttaa ttttaaattc    780

cccgaggtcc ttttactgag atggaaaagc acaaacagtc aaggaaaacc aaagagggag    840

gggtgaggga aggggaaagt gcataaagca cttaaagatt ttttaaaagt aggtatgata    900

gataagccac aagaagtttt taagactact aataaccata attctatttt aatcagctat    960

ttagctggta cctactgcta tatcacctag tgtgacattt cggaattaat ggaacaatga   1020

aggaagctgt acactggagg ttccaggtgg tcatggaagg tttccagttt atgcaaactt   1080

ctgtgaaaat gagctttgtt attggtgaag acattggaaa ttttaccagc caaaacagag   1140

tttctctctt attcagggta agatgtaatt gcagtgtgct agcgctggaa gggacctgtt   1200

ttatatgtta tgtatgttac acgtcagccc tccatgtcct ccagttctgc atccttggat   1260

tcaaccaact gtgggttgaa aatactggag gtaaaaagac aaaaaataac aatgaagaac   1320

aacaacaaaa atacacagta taataattac atttacatag catttatttt gtattagaca   1380

ttataagtaa tctagagatg atttaaagta tatgggagaa tgtatgtaga ttatatggaa   1440

atatgagggt attttattta aagggacttg ggcctgtgga taccaaggaa taactaaggt   1500

aaaactgagc ataagtggcc tgtccatatt ttgttaaata tcagattatt gattagtgat   1560

catcaacatt ttcccgcatt catgcagtgc ggcctctgaa aacatggttg aacatcctat   1620

ggaatttttt tttttttttg agatggagtc tcactctgtc acctaggcta gagtgcaatg   1680

gcgcgatctt ggcttactgc aacctccgcc tgccccacct cgggttcaag tgattctcct   1740

gcctcagcct cctgagtacc tgggactaca ggcatgcacc accacgcccg gctaattttt   1800

gtatttttag acgagacagg gtttcaccct gttggccagg ctggtctcaa actcctaacc   1860

tcaggtgatc caactgcctc ggcctcccaa agtgctggga ttacaggtat gagccaccgt   1920

gcccagcaga attttttaac tatttggtta cgactaattt ggataatgta gtgcatgcag   1980

ctttgatttg tgccactaag agtgggcaaa ctgtcttcct ttttgtgaat cagtaaaaat   2040

tttccctcaa catgtgtttg acagttgtca ttcactgcta agttaaggca tttggtaaac   2100

cacacagcct ctgcatcctt cctagcgaca gccacaagaa aaggtgggca tgggagggaa   2160

aatgctcttg tgaattgaac tggaggcaag ctccactttt ctttagaaaa agatgtagat   2220

caaaataact aatattttct tccttgctcg atttctgtgc cttccatggt acatcaaaat   2280

aataggacca gtaatggcca caatcctgtt gactgctgtt accttcgccc caatatttct   2340

ttaagcattt cttaagcatc tagcttgtgt tttgttatat ttaacagatt ttcttaaagt   2400

attgtatgaa ttaaaaccag aaataacttc attttcctag aaagggataa tttctcccgg   2460

agaataaatc ctgaggattt agttagatgc tgtgggtatt gtattttaaa taatatttta   2520

atgggagcag ctgattgact ttcaaatgga ttgtttacat taatagtaat tctgcagttg   2580

ttttactatt gcatcagtct gccagacaag ttccatgtgc atattttaat tcagaactaa   2640

ttatacttaa aaatttaaac cctgcatact tccccaaaaa tgtttagggc agttaaaaac   2700

aactcttttg gaagatgact cgcattttaa gaaatgagag aacactgtca aatgatgaat   2760

gcatttaaaa aataatttgc aaagtgataa aagcccttag ttttaaatct tacaatgaca   2820

ttagctctta caagaactca gtaagtattt gctgtttttt aatgggatag taataaggtt   2880

gaggtttttg ttaagggacg tttacttatc atcaaactct atacttacta ctacaaggaa   2940

actccaagta cattaaacac tatgttttat aattctttgc cacactgcca ataaattctg   3000

ttcacatttt aaggatgaca agtccactat atgtaacacg taagaatgct atcctggcag   3060

tagacacagg gccagaataa actggcaagt tttcattcca cacaagtgtg ggaaaaaaat   3120

gactacaact taaactttat ttacttgatt gagagcttat tgcacatgaa atgttttatg   3180

tggttgatct taacttcgtt tacattgact tctatgctca agattgttca attgctgctg   3240

ctgccgttgt gttttctttc aggatcgagg tgggtacctt catataatat cttcttttta   3300

atttcttctc tggcaattct ttcctggatt ctttgctttg cataattata cctacaatga   3360

aaccttagaa gaaaagaata tgaataaatt gttaatataa agtcctacag aaattaattt   3420

atgaaatttc tctaaatcac acaaaactta aatacagatg actactaccc tgagactgaa   3480

aaatatgttc taatttatag tgctattttt gggcagtttt ggtgtcagaa tacctatcaa   3540

cacattcttt ttttattagg aaaaaaagga tgtctacata acaatttgta aagtgataaa   3600

atccattagt ttttaagtct tctgatagca ttggctatta taagaaacaa gtatttgctc   3660

tcgtttttaa cgggataata atgctatgtc tacataaaat gatttctacc accttaaata   3720

gctcactgta gaaattcatg tataaatgga accatatagt acatacatat catactctta   3780

ggtctggcaa atatttgagg ttcatccata ttttatattc actcatcagt agttgtaaac   3840

acattcttaa agtagcattt tcagatatga ataagcaggg atgaaataag tattagggta   3900

agggaaatgg ttgaggcttt cctaagtgaa gtgtaaaaac cacagctttc tttttaatgg   3960

gatgtctaat atgcatttat ctgttcaagc attttaagat ttccatgaaa atgtcctgaa   4020

aaatcaagat tcttcattga gggtgaggat ctcccaatgg gagactgctc tgaaaagagc   4080

atgtgctttt tgaattagat aacctactat aatcatggat gttcttgaat acttagcaaa   4140

cataccagca tcccaaagtc accaagataa accctcctac tccaacatca catgatcttc   4200

taattctacc tgtaaaaata agcataacaa ttaattagaa tataattacg ttatatacat   4260

tactccacct agaaaaaaaa atagttcatt atgtagagaa atgctttttt tagtacatag   4320

agaaataaaa aatacagata ctcactagtg aacaaaaaat gtccaaagcc agccacaaca   4380

gatcctaatg aaccatacaa tattgaatgc cgggcgcagg gagtattttc aacatctaaa   4440

aatcctagga gcttaaggga ctagaatgaa aaaaaagaac ctagattgag taagaaagta   4500

tttcattttg gggtgctttg gcaaaaatga caatacacca tttcttttct tgtagttgag   4560

ggtttaaact agagtatgtg ccacgtgaca acctaaatca gcttgcgttg tctttgtcca   4620

cctttggtat gcagtctgaa tctttaaatc cgaaaacctt acaaattgga ccggaaaacc   4680

cttaagcagt agggtaactt ggagctgtat cttaatttgc taatcaactg acttggaaat   4740

aggataattc attttatgag ctctttaaat gagtttattt gggaatatgc ctatcattgg   4800

aattgaaagc agcatagctt gcttcagtaa ctccaataat ttgggaagca gaaatggaaa   4860

aagtaatttg agtcatgttt gcttatgtag tgccgtttaa aattccccta gtaattacct   4920

ttcatatttt attaactagg ttaacatcaa ctgtggttgt aagagtaaat gtttcacctt   4980

aagataaaca tgggcaatat attaaactct agtctgtttt cttgcctgtg aagtgaggct   5040

gcacttgatt atatttgatt ctttgttcgt aatacatggg aacgacagct aagtgtggtg   5100

aaaaacgcgg ggatccaaag agctggattt ttatctcaga tctgccgcta acttttgtat   5160

cctataggct acttttattt ctatggtctc aatctataac atgaatgggt tgggttaaat   5220

gactgaagtt ccttcaagtg ctaaaattct ttttctacag tcttcattgg atttatgtat   5280

ttcttattcc taatatgttt aactgggatg tctgtcactc tagggcggca agacagacat   5340

ttaaaagtaa cagtcacact gctgaactgg catttctgtt aacacaaaag tttagaaaac   5400

tcacggtaac tgttacttga tttaagtgta tataaaattt tcagtaaggc tgcttttaaa   5460

aggaaccact gtccatttaa aggtttcata gttatcttca atgggttagt attgtttggg   5520

gcaggacatt aaactagaag ggattctata ggatgaggtg atacctagaa ggtaatatat   5580

tgtaaggcaa aagagattag aagaaatggg gaaaggatag taaaaggcaa gtcagattaa   5640

aggttgaaac atgaagatat tctcaattgt atttctgcct atgtttgctt ttttggctca   5700

agcatctgtt ggaagagaca aaatgtgact tggttcataa taaagcaaga attatttact   5760

ctcgg                                                               5765


<210>  2083
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  2083

Met Lys Glu Ala Val His Trp Arg Phe Gln Val Val Met Glu Gly Phe 
1               5                   10                  15


Gln Phe Met Gln Thr Ser Val Lys Met Ser Phe Val Ile Gly Glu Asp 
            20                  25                  30


Ile Gly Asn Phe Thr Ser Gln Asn Arg Val Ser Leu Leu Phe Arg Val 
        35                  40                  45


Arg Cys Asn Cys Ser Val Leu Ala Leu Glu Gly Thr Cys Phe Ile Cys 
    50                  55                  60


Tyr Val Cys Tyr Thr Ser Ala Leu His Val Leu Gln Phe Cys Ile Leu 
65                  70                  75                  80


Gly Phe Asn Gln Leu Trp Val Glu Asn Thr Gly Gly Lys Lys Thr Lys 
                85                  90                  95


Asn Asn Asn Glu Glu Gln Gln Gln Lys Tyr Thr Val 
            100                 105


<210>  2084
<211>  5587
<212>  DNA
<213>  Homo sapiens

<400>  2084
aacaatcgtg gctacaaaaa tcaatctcag ggctacaacc agtggcagca gggtgtaagt     60

aatttcttat gtgctttatg tacattaatt gtattttgag ttcctaagat ttatcagtct    120

tgaaaaagat cttgttcagg gattgaagtg tttataagtg ttaatagggt aaagtgtgaa    180

tcgtcttgca gtagtagcca taatctacct tttgaaggca aaataggttg aagattgcta    240

taagttaaat ttttttaata aagtaatatt atttaatata tacagttctt ttactgctag    300

ctttaattgt gtaaactaac aaagtcatga tgtttcgttt tgtaatgtgt attgataatt    360

atgggatatt aaaactaaat ctggtttggt agaaatcaga ggtatgacag gtataaattt    420

gtttccagca aattactctg aattagattc attgtcattt cctaaaaaca gtttgagtgg    480

cttattgatg ttttttcttt aaaaacaaaa ttttctctta cagcaattct ggggtcagaa    540

gccatggagt cagcattatc accaaggata ttattgaata cccaaataaa acgaactgat    600

acatatttct ccaaaacctt cacaagaagt cgactgtttt ctttagtagg ctaacttttt    660

aaacattcca caagaggaag tgcctgcggg ttcctttttt agaagctttt ctgtccatgt    720

gaatgtgctg tgtggaagag ttaaagggcc caactaaatg ttccagtgat tccaatagct    780

atttagctgg tacctactgc tatatcacct agtgtgacat ttcggaatta atggaacaat    840

gaaggaagct gtacactgga ggttccaggt ggtcatggaa ggtttccagt ttatgcaaac    900

ttctgtgaaa atgagctttg ttattggtga agacattgga aattttacca gccaaaacag    960

agtttctctc ttattcaggg taagatgtaa ttgcagtgtg ctagcgctgg aagggacctg   1020

ttttatatgt tatgtatgtt acacgtcagc cctccatgtc ctccagttct gcatccttgg   1080

attcaaccaa ctgtgggttg aaaatactgg aggtaaaaag acaaaaaata acaatgaaga   1140

acaacaacaa aaatacacag tataataatt acatttacat agcatttatt ttgtattaga   1200

cattataagt aatctagaga tgatttaaag tatatgggag aatgtatgta gattatatgg   1260

aaatatgagg gtattttatt taaagggact tgggcctgtg gataccaagg aataactaag   1320

gtaaaactga gcataagtgg cctgtccata ttttgttaaa tatcagatta ttgattagtg   1380

atcatcaaca ttttcccgca ttcatgcagt gcggcctctg aaaacatggt tgaacatcct   1440

atggaatttt tttttttttt tgagatggag tctcactctg tcacctaggc tagagtgcaa   1500

tggcgcgatc ttggcttact gcaacctccg cctgccccac ctcgggttca agtgattctc   1560

ctgcctcagc ctcctgagta cctgggacta caggcatgca ccaccacgcc cggctaattt   1620

ttgtattttt agacgagaca gggtttcacc ctgttggcca ggctggtctc aaactcctaa   1680

cctcaggtga tccaactgcc tcggcctccc aaagtgctgg gattacaggt atgagccacc   1740

gtgcccagca gaatttttta actatttggt tacgactaat ttggataatg tagtgcatgc   1800

agctttgatt tgtgccacta agagtgggca aactgtcttc ctttttgtga atcagtaaaa   1860

attttccctc aacatgtgtt tgacagttgt cattcactgc taagttaagg catttggtaa   1920

accacacagc ctctgcatcc ttcctagcga cagccacaag aaaaggtggg catgggaggg   1980

aaaatgctct tgtgaattga actggaggca agctccactt ttctttagaa aaagatgtag   2040

atcaaaataa ctaatatttt cttccttgct cgatttctgt gccttccatg gtacatcaaa   2100

ataataggac cagtaatggc cacaatcctg ttgactgctg ttaccttcgc cccaatattt   2160

ctttaagcat ttcttaagca tctagcttgt gttttgttat atttaacaga ttttcttaaa   2220

gtattgtatg aattaaaacc agaaataact tcattttcct agaaagggat aatttctccc   2280

ggagaataaa tcctgaggat ttagttagat gctgtgggta ttgtatttta aataatattt   2340

taatgggagc agctgattga ctttcaaatg gattgtttac attaatagta attctgcagt   2400

tgttttacta ttgcatcagt ctgccagaca agttccatgt gcatatttta attcagaact   2460

aattatactt aaaaatttaa accctgcata cttccccaaa aatgtttagg gcagttaaaa   2520

acaactcttt tggaagatga ctcgcatttt aagaaatgag agaacactgt caaatgatga   2580

atgcatttaa aaaataattt gcaaagtgat aaaagccctt agttttaaat cttacaatga   2640

cattagctct tacaagaact cagtaagtat ttgctgtttt ttaatgggat agtaataagg   2700

ttgaggtttt tgttaaggga cgtttactta tcatcaaact ctatacttac tactacaagg   2760

aaactccaag tacattaaac actatgtttt ataattcttt gccacactgc caataaattc   2820

tgttcacatt ttaaggatga caagtccact atatgtaaca cgtaagaatg ctatcctggc   2880

agtagacaca gggccagaat aaactggcaa gttttcattc cacacaagtg tgggaaaaaa   2940

atgactacaa cttaaacttt atttacttga ttgagagctt attgcacatg aaatgtttta   3000

tgtggttgat cttaacttcg tttacattga cttctatgct caagattgtt caattgctgc   3060

tgctgccgtt gtgttttctt tcaggatcga ggtgggtacc ttcatataat atcttctttt   3120

taatttcttc tctggcaatt ctttcctgga ttctttgctt tgcataatta tacctacaat   3180

gaaaccttag aagaaaagaa tatgaataaa ttgttaatat aaagtcctac agaaattaat   3240

ttatgaaatt tctctaaatc acacaaaact taaatacaga tgactactac cctgagactg   3300

aaaaatatgt tctaatttat agtgctattt ttgggcagtt ttggtgtcag aatacctatc   3360

aacacattct ttttttatta ggaaaaaaag gatgtctaca taacaatttg taaagtgata   3420

aaatccatta gtttttaagt cttctgatag cattggctat tataagaaac aagtatttgc   3480

tctcgttttt aacgggataa taatgctatg tctacataaa atgatttcta ccaccttaaa   3540

tagctcactg tagaaattca tgtataaatg gaaccatata gtacatacat atcatactct   3600

taggtctggc aaatatttga ggttcatcca tattttatat tcactcatca gtagttgtaa   3660

acacattctt aaagtagcat tttcagatat gaataagcag ggatgaaata agtattaggg   3720

taagggaaat ggttgaggct ttcctaagtg aagtgtaaaa accacagctt tctttttaat   3780

gggatgtcta atatgcattt atctgttcaa gcattttaag atttccatga aaatgtcctg   3840

aaaaatcaag attcttcatt gagggtgagg atctcccaat gggagactgc tctgaaaaga   3900

gcatgtgctt tttgaattag ataacctact ataatcatgg atgttcttga atacttagca   3960

aacataccag catcccaaag tcaccaagat aaaccctcct actccaacat cacatgatct   4020

tctaattcta cctgtaaaaa taagcataac aattaattag aatataatta cgttatatac   4080

attactccac ctagaaaaaa aaatagttca ttatgtagag aaatgctttt tttagtacat   4140

agagaaataa aaaatacaga tactcactag tgaacaaaaa atgtccaaag ccagccacaa   4200

cagatcctaa tgaaccatac aatattgaat gccgggcgca gggagtattt tcaacatcta   4260

aaaatcctag gagcttaagg gactagaatg aaaaaaaaga acctagattg agtaagaaag   4320

tatttcattt tggggtgctt tggcaaaaat gacaatacac catttctttt cttgtagttg   4380

agggtttaaa ctagagtatg tgccacgtga caacctaaat cagcttgcgt tgtctttgtc   4440

cacctttggt atgcagtctg aatctttaaa tccgaaaacc ttacaaattg gaccggaaaa   4500

cccttaagca gtagggtaac ttggagctgt atcttaattt gctaatcaac tgacttggaa   4560

ataggataat tcattttatg agctctttaa atgagtttat ttgggaatat gcctatcatt   4620

ggaattgaaa gcagcatagc ttgcttcagt aactccaata atttgggaag cagaaatgga   4680

aaaagtaatt tgagtcatgt ttgcttatgt agtgccgttt aaaattcccc tagtaattac   4740

ctttcatatt ttattaacta ggttaacatc aactgtggtt gtaagagtaa atgtttcacc   4800

ttaagataaa catgggcaat atattaaact ctagtctgtt ttcttgcctg tgaagtgagg   4860

ctgcacttga ttatatttga ttctttgttc gtaatacatg ggaacgacag ctaagtgtgg   4920

tgaaaaacgc ggggatccaa agagctggat ttttatctca gatctgccgc taacttttgt   4980

atcctatagg ctacttttat ttctatggtc tcaatctata acatgaatgg gttgggttaa   5040

atgactgaag ttccttcaag tgctaaaatt ctttttctac agtcttcatt ggatttatgt   5100

atttcttatt cctaatatgt ttaactggga tgtctgtcac tctagggcgg caagacagac   5160

atttaaaagt aacagtcaca ctgctgaact ggcatttctg ttaacacaaa agtttagaaa   5220

actcacggta actgttactt gatttaagtg tatataaaat tttcagtaag gctgctttta   5280

aaaggaacca ctgtccattt aaaggtttca tagttatctt caatgggtta gtattgtttg   5340

gggcaggaca ttaaactaga agggattcta taggatgagg tgatacctag aaggtaatat   5400

attgtaaggc aaaagagatt agaagaaatg gggaaaggat agtaaaaggc aagtcagatt   5460

aaaggttgaa acatgaagat attctcaatt gtatttctgc ctatgtttgc ttttttggct   5520

caagcatctg ttggaagaga caaaatgtga cttggttcat aataaagcaa gaattattta   5580

ctctcgg                                                             5587


<210>  2085
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  2085

Met Lys Glu Ala Val His Trp Arg Phe Gln Val Val Met Glu Gly Phe 
1               5                   10                  15


Gln Phe Met Gln Thr Ser Val Lys Met Ser Phe Val Ile Gly Glu Asp 
            20                  25                  30


Ile Gly Asn Phe Thr Ser Gln Asn Arg Val Ser Leu Leu Phe Arg Val 
        35                  40                  45


Arg Cys Asn Cys Ser Val Leu Ala Leu Glu Gly Thr Cys Phe Ile Cys 
    50                  55                  60


Tyr Val Cys Tyr Thr Ser Ala Leu His Val Leu Gln Phe Cys Ile Leu 
65                  70                  75                  80


Gly Phe Asn Gln Leu Trp Val Glu Asn Thr Gly Gly Lys Lys Thr Lys 
                85                  90                  95


Asn Asn Asn Glu Glu Gln Gln Gln Lys Tyr Thr Val 
            100                 105


<210>  2086
<211>  1283
<212>  DNA
<213>  Homo sapiens

<400>  2086
ctctctcaga attagtattt gcctattaat gtaatcagtg tagccttctc aacataaaaa     60

tgtccttatt ctagaacatg gaagcgtacg gcaaatgcaa cggttgaaag cactgaaaaa    120

tatttgtaaa acatctgtag tgctcacatt atgaacttta aatgtaatac tttgaaaacc    180

atcttcataa tttttttgtt ctaacagctt cctttttaag aaaacatttt aaaacatttt    240

aaaatggaac ttaatgtgca aaataagttg tgtaaaatac cagtatttgg gtggtggagg    300

atattggtat attatattga cctgggttga tgactactgg actattttaa gatacctact    360

tccaaaactt attttattct agaggaccac taaaaatcag aattacagca atcattttaa    420

tttttctact ttccttgtta aggtcttctg cttacccaaa gaatagtgta tatcttaaca    480

tgacttttaa aggggtatct tgatccccat cacagatttt tatctatgaa tagaaggatt    540

gaaaccctat ttgatcccta gctctttgct gaaaagtgca taaacaggaa tcctgaattt    600

attatataga cctcctcgca ttatataatc gaagcaaagg gaaaccagcg atggagtaga    660

ggtacgtaga ctaaagagat gcttgcaaat gatggtacct agggatagtc acattttctt    720

gttgccaaac tcagacaata taatcacaag tccagagaag agctagttaa ttttaaattc    780

cccgaggtcc ttttactgag atggaaaagc acaaacagtc aaggaaaacc aaagagggag    840

gggtgaggga aggggaaagt gcataaagca cttaaagatt ttttaaaagt aggtatgata    900

gataagccac aagaagtttt taagactact aataaccata attctatttt aatcagctat    960

ttagctggta cctactgcta tatcacctag tgtgacattt cggaattaat ggaacaatga   1020

aggaagctgt acactggagg ttccaggtgg tcatggaagg taggttactc ttaaagtttg   1080

aaattgtaaa gtgtgaaagt ctggatagag gggaagggga acctggacta tttttatttt   1140

tttttgagac gagtctggct ctgtcgccaa ggctggagtg tagtgacccg agatcacgcc   1200

attgtactcc agcctgggcg acgagagtga aactccatct caagagagaa aaaaaaaagg   1260

tcatagtgca ttgaaggttt ggc                                           1283


<210>  2087
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  2087

Met Lys Glu Ala Val His Trp Arg Phe Gln Val Val Met Glu Gly Arg 
1               5                   10                  15


Leu Leu Leu Lys Phe Glu Ile Val Lys Cys Glu Ser Leu Asp Arg Gly 
            20                  25                  30


Glu Gly Glu Pro Gly Leu Phe Leu Phe Phe Phe Glu Thr Ser Leu Ala 
        35                  40                  45


Leu Ser Pro Arg Leu Glu Cys Ser Asp Pro Arg Ser Arg His Cys Thr 
    50                  55                  60


Pro Ala Trp Ala Thr Arg Val Lys Leu His Leu Lys Arg Glu Lys Lys 
65                  70                  75                  80


Lys Val Ile Val His 
                85


<210>  2088
<211>  8000
<212>  DNA
<213>  Homo sapiens

<400>  2088
acgaagagct ggagaaacac ataagaaggc agatctaaga tggaagaaaa ggcggattcg     60

ggttgaaacg ccaagttgag gactgaagaa agcatttgga taaagcagcc tccaagctgg    120

gaaggagaaa agccaaacga gtatagccac caaagaccca gaaaggccaa tatatcatgc    180

agtgagtcgg ttgaactgaa aggcggtttc cttttcctcc atttgctcag tcccaattgg    240

aagcgcactg cgcggcctcc accgcgctct cggcccgggt tcggcgtggg ggcggggagg    300

taagtacggt aatgggcggg gccgagcgcg ggcgcgctcc ggctttcctc ctgcgcagtg    360

ctcccgtcag cgcagggggc ggggcgccta tattacgtgc gcggcgccgc tcctgcgaga    420

ggacgttgcg tgctcgctcg cgccaggcga gtctccgcgt ctccctcgcg aactcggtga    480

aaggaattgg cgccgttcga caccaggcgg atccgctctg cagcacgaac ccatctccag    540

ccgcagccgc agccgccgcc cgggccgagg agcagccgca gcagccgcca ccagtggccg    600

agtgagcgga gccgagtttg aggcagcgcc tagcggtgaa tcggggccct caccatgagt    660

tcctcgcctg ttaatgtaaa aaagctgaag gtgtcggagc tgaaagagga gctcaagaag    720

cgacgccttt ctgacaaggg tctcaaggcc gagctcatgg agcgactcca ggctgcgctg    780

gacgacgagg aggccggggg ccgccccgcc atggagcccg ggaacggcag cctagacctg    840

ggcggggatt ccgctgggcg ctcgggagca ggcctcgagc aggaggccgc ggccggcggc    900

gatgaagagg aggaggaaga ggaagaggag gaggaaggaa tctccgctct ggacggcgac    960

cagatggagc taggagagga gaacggggcc gcgggggcgg ccgactcggg cccgatggag   1020

gaggaggagg ccgcctcgga agacgagaac ggcgacgatc agggtttcca ggaaggggaa   1080

gatgagctcg gggacgaaga ggaaggcgcg ggcgacgaga acgggcacgg ggagcagcag   1140

cctcaaccgc cggcgacgca gcagcaacag ccccaacagc agcgcggggc cgccaaggag   1200

gccgcgggga agagcagcgg ccccacctcg ctgttcgcgg tgacggtggc gccgcccggg   1260

gcgaggcagg gccagcagca ggcgggaggt aagaagaagg cggaaggcgg cggaggcggc   1320

ggtcgccccg gggctccggc ggcgggggac ggcaaaacag aacagaaagg cggagataaa   1380

aagaggggtg ttaaaagacc acgagaagat catggccgtg gatattttga gtacattgaa   1440

gagaacaagt atagcagagc caaatctcct cagccacctg ttgaagaaga agatgaacac   1500

ttcgatgaca cagtggtttg tcttgatact tataattgtg atctacattt taaaatatca   1560

agagatcgtc tcagtgcttc ttcccttaca atggagagtt ttgcttttct ttgggctgga   1620

ggaagagcat cctatggtgt gtcaaaaggc aaagtgtgtt ttgagatgaa ggttacagag   1680

aagatcccag taaggcattt atatacaaaa gatattgaca tacatgaagt tcgtattggc   1740

tggtcactaa ctacaagtgg aatgttactt ggtgaagaag aattttctta tgggtattct   1800

ctaaaaggaa taaaaacatg caactgtgag actgaagatt atggagaaaa gtttgatgaa   1860

aatgatgtga ttacatgttt tgctaacttt gaaagtgatg aagtagaact ctcgtatgct   1920

aagaatggac aagatcttgg cgttgccttc aaaatcagta aggaagttct tgctggacgg   1980

ccactgttcc cgcatgttct ctgccacaac tgtgcagttg aatttaattt tggtcagaag   2040

gaaaagccat attttccaat acctgaagag tatactttca tccagaacgt ccccttagag   2100

gatcgagtta gaggaccaaa ggggcctgaa gagaagaaag attgtgaagt tgtgatgatg   2160

attggcttgc caggagctgg aaaaactacc tgggttacta aacatgcagc agaaaatcca   2220

gggaaatata acattcttgg cacaaatact attatggata agatgatggt ggcaggtttt   2280

aagaagcaaa tggcagatac tggaaaactg aacacactgt tgcagagagc cccccagtgt   2340

cttgggaaat ttattgagat tgctgcccga aagaagcgaa attttattct ggatcagaca   2400

aatgtgtctg ctgctgccca gaggagaaaa atgtgcctgt ttgcaggctt ccagcgaaaa   2460

gctgttgtag tttgcccaaa agatgaagac tataagcaaa gaacacagaa gaaagcagaa   2520

gtagagggga aagacctacc agaacatgcg gtcctcaaaa tgaaaggaaa ctttaccctc   2580

ccagaggtag ctgagtgctt tgatgaaata acctatgttg aacttcagaa ggaagaagcc   2640

caaaaactct tggagcaata taaggaagaa agcaaaaagg ctcttccacc agaaaagaaa   2700

cagaacactg gctcaaagaa aagcaataaa aataagagtg gcaagaacca gtttaacaga   2760

ggtggtggcc atagaggacg tggaggattc aatatgcgtg gtggaaattt cagaggagga   2820

ggcaacccct gggaatcgtg gcggatataa taggaggggc aacatgccac agagaggtgg   2880

tggcggtgga ggaagtggtg gaatcggcta tccataccct cgtgcccctg tttttcctgg   2940

ccgtggtagt tactcaaaca gagggaacta caacagaggt ggaatgccca acagagggaa   3000

ctacaaccag aacttcagag gacgaggaaa caatcgtggc tacaaaaatc aatctcaggg   3060

ctacaaccag tggcagcagg gtcaattctg gggtcagaag ccatggagtc agcattatca   3120

ccaaggatat tattgaatac ccaaataaaa cgaactgata catatttctc caaaaccttc   3180

acaagaagtc gactgttttc tttagtaggc taacttttta aacattccac aagaggaagt   3240

gcctgcgggt tcctttttta gaagctttgt gggttgattt tttttctttt cttttttgta   3300

catttttaat tgcagtttaa aagtgaatcg taagagaacc tcagcattgt gcacgataag   3360

agaatgtgtc agtatttcag ggttctacat tttatctgta aaatgtgact tttttttttt   3420

tttatcacaa cagaagtaaa atgttgcttt gtacctggtg tcttttatta agaatttact   3480

ccccccattt ctcacagaga ataacagtcg ggagtcattg tcacaatata atagaaatgt   3540

tagcaaccag attcatgtaa ggactaagtg gtcctcatga attgcattaa gactctgtac   3600

tgctcatatt acactccatc ctctctgtag tttgctgggt agtggagggg gtaagctaaa   3660

tcatagtttc tgacaataac tgggaaggtt ttttcttaaa ataacaatgg aattggtata   3720

attgggattg aaaactaaaa cttggaacta agatagagaa gatggagtgt atgtagaagg   3780

gctgttaaaa atgtaaaact tggttgcatt atttgtggag gctcaaactt gtgaaggtta   3840

ataccataat ttttccattt gttctgcatt ttgattctga aaagaaagct ggctttgccc   3900

atttcttatt aaaaaaactt gttgtaaatc cagttgtcta atgggatcta tatgaagtta   3960

gccatgtctg tatgcccttc tcccacaaaa tactgtataa ctagtgtgct tgtagtagtt   4020

aactccacca tctttgtaag ctaatgaaat tgtgagtcac ccatttatat cttaattttt   4080

aatcatgtca gttcttgaat gggtatctcc ttagcctgct gatttctttt tctttctaaa   4140

gaaagtgggt ggagaaatta atttagacgt ttgtttgcaa taaaaagaat tcattttact   4200

cttgttttgg gattctcgcc atcaaggttc aaaatccctt tatataactc ccaagaggag   4260

aaatttatta agtgtgtgct ttctggacag cttattcttt actctgcata gaacatttag   4320

gttttaaaaa cttaaatgta tactgacaat tgatacataa ttatgaagta aagttgaatt   4380

cttcccttcc cctccccccc agacaacttt taacatattt aatgagggga aaaggtactg   4440

gctgggagaa gttaacactg agtttatcat ctttacagaa tgctaatgct gtcctcaact   4500

gattatttta tatacatata tatgatacat gaaactctgg gatcagatgc ttttagaagc   4560

catcatgcaa gccagtcatt gatgtcactg ctacacaaca ctgctaactt gactgtagct   4620

atgtaataac attagatccc ctaattgtaa ttatattggg tttgcacaga acactttaat   4680

cttcccctca ccaatgtgaa gtgaggaatc aggagtcaaa ctgtagaact aaaatttgac   4740

ttcagtctag cgtttccttg gtgtttttag gttgctttgg taagtttagg tttgctatat   4800

ttctgattgc ttagaatttt gttttagccc tttaaaatca gatcataaat atgaattcat   4860

acttctaagg aattttcttg ctataagctg gagtttaggt gatgtatagg ttcagttgag   4920

acatttttgg aacaggcaaa tccttagtta acataagata tttaacagtt gaagatagtg   4980

tcatggattt ttatcttttt tagcaagtaa tgctaagaac cactggcctg agctactact   5040

cttcagtata cattattagg attgcataga cttactagag gaacagtttc aggttttgat   5100

gctaatcagt gttgtgtcct aaagttgtcc tttgtgcctt taaaaagttt tggatatatc   5160

ttctagttta aaattgctta ttaaggaatt cattttataa ttgcagtggg aaagtaatgg   5220

tcaagtaaca ctaggtagac tatcatgcct gtttagccca gagaatttgg ggggagagag   5280

aatagataaa aatggcaccc agaaaaatgt taaaatcttt agtcaagact agaattaata   5340

caattgtcta cacttgtatg gcagaaataa ccttataaag tgtttaagga attcagagaa   5400

gggaatgtac caaataagca acagggagaa aattaggtaa gaagtaagat acgaacgaga   5460

aacctgattt attgctcatc cttcccttgc ctccctaatg gcaagcaaaa ctctgaacat   5520

ctgaaaagga tgtagttctg gacaaatcct gactacccag aggaaactca ctgtgagatt   5580

gctgttgatt tgaagggtgc tttcactaag gttatatttt aaagtagaat aacacatgct   5640

gagtgtaaac tggctttgga ttggtcagct gcagtagtac aaaaacagca tagaatttga   5700

gaaaactaaa actgctatga gatagctatg agaaaactaa aactgctatg agatagaaat   5760

gatgtaaaat tatgtggaaa gttttccctc atatactcac atacagcctt tgaagggctc   5820

tggctctgac cggttgatgg ccttgagcga gatgaaatca tgaaattgag tcaaatcaat   5880

ttgacattga aatgacaaga ggaaactctt aaatacataa aaacaagctc tcatttgcct   5940

aggatagata ctgtcttaaa aataaagact gaacctagat gttctgagca ctagcaacaa   6000

ggtattttaa caagtttaaa ggaattctct gaaaaagtta taaaattatt ctaggaaaca   6060

taaccataat agtgttttaa gggactttca cctggggatt ttatattcat gaacagagtg   6120

tattctgtat ttaaaatgtc tcatttgtgg gaattggatg acatgttttt tgataaattt   6180

attcacaata taaattgact ttttattcta ggaccatgtg aataatgggt tccattgcac   6240

aaatacaaat attttaatag cttcttaggc agtggtgtag acatcttgga tataaataat   6300

tgtagatctt gtatatttga tttttaaaaa actagaataa acagagaggc ataaacatat   6360

cttagagtcc aagtggtagt gtttagcatt ggatataata aatggatgtt ttacaaagtg   6420

tttccataat tctcttccta tacataaatg tcttgttttc aaaagtggat ggaacttgtg   6480

gatggaactt gtagcagaga attttatcta cttctcaacc tgcttcagaa tacccatttg   6540

agatgttccc ctggaaagat gaacacaata ctgcatctga agccatttct tcccacctaa   6600

cattcttaaa atgattagag tctaaacttt gtcattcatt cctaattctg gagctctgag   6660

gttgaggtgt tcagagtttg gtgaataatt gggtttaagt tttaacattt tagtaataat   6720

aaaagcaaac acatacatgt taaggcctga caataggttg caatacccat gcattgggac   6780

tcatacccag cataaatggt gagggactga acattagtgc tttgagcaag aattggttaa   6840

ctacctgaga tctctaaaac agtaatttga attactaata cataaaccac aagtctcttc   6900

gaattgttaa ttgcctaaat ttaccctaaa acttagttaa cgctgcagtg cctttattaa   6960

agcttttttt tggggggggg tgtgggcaca gctactccat aactttaaat tttaaagcat   7020

gaaggtgatc tagctagtgt tagtgcttga gttggtagtt acataggctg ctcttgaatc   7080

gtcctgtttt ctttgcctag tattagcacc acaggtacat atttgtaaaa taagcattaa   7140

aagtactttg tccagctaac tcatgttgga gtgacctttg tcttactaac ctttgttact   7200

aaacttgtta attagaataa gcccttgaga atttggaagt gagctatact actaatgtag   7260

tatatatctc ttgagtgtgt tggagtagat gaaaaaccag gggtccccaa gggtatattt   7320

ttgaaattga acagaaacaa ttcatcttaa tatttagttt tcattatgtt tagcttaata   7380

tgtgtgctag tttatttggc gtcacactta tgtcaatctc aagtcatgca gaaatagcac   7440

agtctcagaa aagaggttag gtgggaaata gatgatatgc ttacattatt gagcaggact   7500

atgctttcac atcctaacca attgactaaa aatataaatg attgaagtaa ttttcattag   7560

ttgccccagg agtctttaat aatagtttta agggatagta gattggacat agatagatgg   7620

gttattcata atggatattc ataatggata ttcataatgt taacctagaa ttattcagaa   7680

aatataacac ctatgtagta gaatctattg attgtaagcc tagtgttggt aggcaaacat   7740

gttgatgatg ggccaggaca tcagtaatca ctacttggtt aggcaagtaa ttaggacagg   7800

gattgtaatc atgtcaattt gtagctacct aatttttatt gattaggata ctttattttt   7860

catgccagga ttcagcatat acttaggtct tgagcagggg ctttgctttt aaagctgaat   7920

cctgggcata agaagctatg tactgtagtt gaaagtgaag taaatgtcaa tgtaggctag   7980

tctctagaga aatgtcttct                                               8000


<210>  2089
<211>  731
<212>  PRT
<213>  Homo sapiens

<400>  2089

Met Ser Ser Ser Pro Val Asn Val Lys Lys Leu Lys Val Ser Glu Leu 
1               5                   10                  15


Lys Glu Glu Leu Lys Lys Arg Arg Leu Ser Asp Lys Gly Leu Lys Ala 
            20                  25                  30


Glu Leu Met Glu Arg Leu Gln Ala Ala Leu Asp Asp Glu Glu Ala Gly 
        35                  40                  45


Gly Arg Pro Ala Met Glu Pro Gly Asn Gly Ser Leu Asp Leu Gly Gly 
    50                  55                  60


Asp Ser Ala Gly Arg Ser Gly Ala Gly Leu Glu Gln Glu Ala Ala Ala 
65                  70                  75                  80


Gly Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ile 
                85                  90                  95


Ser Ala Leu Asp Gly Asp Gln Met Glu Leu Gly Glu Glu Asn Gly Ala 
            100                 105                 110


Ala Gly Ala Ala Asp Ser Gly Pro Met Glu Glu Glu Glu Ala Ala Ser 
        115                 120                 125


Glu Asp Glu Asn Gly Asp Asp Gln Gly Phe Gln Glu Gly Glu Asp Glu 
    130                 135                 140


Leu Gly Asp Glu Glu Glu Gly Ala Gly Asp Glu Asn Gly His Gly Glu 
145                 150                 155                 160


Gln Gln Pro Gln Pro Pro Ala Thr Gln Gln Gln Gln Pro Gln Gln Gln 
                165                 170                 175


Arg Gly Ala Ala Lys Glu Ala Ala Gly Lys Ser Ser Gly Pro Thr Ser 
            180                 185                 190


Leu Phe Ala Val Thr Val Ala Pro Pro Gly Ala Arg Gln Gly Gln Gln 
        195                 200                 205


Gln Ala Gly Gly Lys Lys Lys Ala Glu Gly Gly Gly Gly Gly Gly Arg 
    210                 215                 220


Pro Gly Ala Pro Ala Ala Gly Asp Gly Lys Thr Glu Gln Lys Gly Gly 
225                 230                 235                 240


Asp Lys Lys Arg Gly Val Lys Arg Pro Arg Glu Asp His Gly Arg Gly 
                245                 250                 255


Tyr Phe Glu Tyr Ile Glu Glu Asn Lys Tyr Ser Arg Ala Lys Ser Pro 
            260                 265                 270


Gln Pro Pro Val Glu Glu Glu Asp Glu His Phe Asp Asp Thr Val Val 
        275                 280                 285


Cys Leu Asp Thr Tyr Asn Cys Asp Leu His Phe Lys Ile Ser Arg Asp 
    290                 295                 300


Arg Leu Ser Ala Ser Ser Leu Thr Met Glu Ser Phe Ala Phe Leu Trp 
305                 310                 315                 320


Ala Gly Gly Arg Ala Ser Tyr Gly Val Ser Lys Gly Lys Val Cys Phe 
                325                 330                 335


Glu Met Lys Val Thr Glu Lys Ile Pro Val Arg His Leu Tyr Thr Lys 
            340                 345                 350


Asp Ile Asp Ile His Glu Val Arg Ile Gly Trp Ser Leu Thr Thr Ser 
        355                 360                 365


Gly Met Leu Leu Gly Glu Glu Glu Phe Ser Tyr Gly Tyr Ser Leu Lys 
    370                 375                 380


Gly Ile Lys Thr Cys Asn Cys Glu Thr Glu Asp Tyr Gly Glu Lys Phe 
385                 390                 395                 400


Asp Glu Asn Asp Val Ile Thr Cys Phe Ala Asn Phe Glu Ser Asp Glu 
                405                 410                 415


Val Glu Leu Ser Tyr Ala Lys Asn Gly Gln Asp Leu Gly Val Ala Phe 
            420                 425                 430


Lys Ile Ser Lys Glu Val Leu Ala Gly Arg Pro Leu Phe Pro His Val 
        435                 440                 445


Leu Cys His Asn Cys Ala Val Glu Phe Asn Phe Gly Gln Lys Glu Lys 
    450                 455                 460


Pro Tyr Phe Pro Ile Pro Glu Glu Tyr Thr Phe Ile Gln Asn Val Pro 
465                 470                 475                 480


Leu Glu Asp Arg Val Arg Gly Pro Lys Gly Pro Glu Glu Lys Lys Asp 
                485                 490                 495


Cys Glu Val Val Met Met Ile Gly Leu Pro Gly Ala Gly Lys Thr Thr 
            500                 505                 510


Trp Val Thr Lys His Ala Ala Glu Asn Pro Gly Lys Tyr Asn Ile Leu 
        515                 520                 525


Gly Thr Asn Thr Ile Met Asp Lys Met Met Val Ala Gly Phe Lys Lys 
    530                 535                 540


Gln Met Ala Asp Thr Gly Lys Leu Asn Thr Leu Leu Gln Arg Ala Pro 
545                 550                 555                 560


Gln Cys Leu Gly Lys Phe Ile Glu Ile Ala Ala Arg Lys Lys Arg Asn 
                565                 570                 575


Phe Ile Leu Asp Gln Thr Asn Val Ser Ala Ala Ala Gln Arg Arg Lys 
            580                 585                 590


Met Cys Leu Phe Ala Gly Phe Gln Arg Lys Ala Val Val Val Cys Pro 
        595                 600                 605


Lys Asp Glu Asp Tyr Lys Gln Arg Thr Gln Lys Lys Ala Glu Val Glu 
    610                 615                 620


Gly Lys Asp Leu Pro Glu His Ala Val Leu Lys Met Lys Gly Asn Phe 
625                 630                 635                 640


Thr Leu Pro Glu Val Ala Glu Cys Phe Asp Glu Ile Thr Tyr Val Glu 
                645                 650                 655


Leu Gln Lys Glu Glu Ala Gln Lys Leu Leu Glu Gln Tyr Lys Glu Glu 
            660                 665                 670


Ser Lys Lys Ala Leu Pro Pro Glu Lys Lys Gln Asn Thr Gly Ser Lys 
        675                 680                 685


Lys Ser Asn Lys Asn Lys Ser Gly Lys Asn Gln Phe Asn Arg Gly Gly 
    690                 695                 700


Gly His Arg Gly Arg Gly Gly Phe Asn Met Arg Gly Gly Asn Phe Arg 
705                 710                 715                 720


Gly Gly Gly Asn Pro Trp Glu Ser Trp Arg Ile 
                725                 730


<210>  2090
<211>  7904
<212>  DNA
<213>  Homo sapiens

<400>  2090
acgaagagct ggagaaacac ataagaaggc agatctaaga tggaagaaaa ggcggattcg     60

ggttgaaacg ccaagttgag gactgaagaa agcatttgga taaagcagcc tccaagctgg    120

gaaggagaaa agccaaacga gtatagccac caaagaccca gaaaggccaa tatatcatgc    180

agtgagtcgg ttgaactgaa aggcggtttc cttttcctcc atttgctcag tcccaattgg    240

aagcgcactg cgcggcctcc accgcgctct cggcccgggt tcggcgtggg ggcggggagg    300

taagtacggt aatgggcggg gccgagcgcg ggcgcgctcc ggctttcctc ctgcgcagtg    360

ctcccgtcag cgcagggggc ggggcgccta tattacgtgc gcggcgccgc tcctgcgaga    420

ggacgttgcg tgctcgctcg cgccaggcga gtctccgcgt ctccctcgcg aactcggtga    480

aaggaattgg cgccgttcga caccaggcgg atccgctctg cagcacgaac ccatctccag    540

ccgcagccgc agccgccgcc cgggccgagg agcagccgca gcagccgcca ccagtggccg    600

agtgagcgga gccgagtttg aggcagcgcc tagcggtgaa tcggggccct caccatgagt    660

tcctcgcctg ttaatgtaaa aaagctgaag gtgtcggagc tgaaagagga gctcaagaag    720

cgacgccttt ctgacaaggg tctcaaggcc gagctcatgg agcgactcca ggctgcgctg    780

gacgacgagg aggccggggg ccgccccgcc atggagcccg gaacggcgac gatcagggtt    840

tccaggaagg ggaagatgag ctcggggacg aagaggaagg cgcgggcgac gagaacgggc    900

acggggagca gcagcctcaa ccgccggcga cgcagcagca acagccccaa cagcagcgcg    960

gggccgccaa ggaggccgcg gggaagagca gcggccccac ctcgctgttc gcggtgacgg   1020

tggcgccgcc cggggcgagg cagggccagc agcaggcggg aggtaagaag aaggcggaag   1080

gcggcggagg cggcggtcgc cccggggctc cggcggcggg ggacggcaaa acagaacaga   1140

aaggcggaga taaaaagagg ggtgttaaaa gaccacgaga agatcatggc cgtggatatt   1200

ttgagtacat tgaagagaac aagtatagca gagccaaatc tcctcagcca cctgttgaag   1260

aagaagatga acacttcgat gacacagtgg tttgtcttga tacttataat tgtgatctac   1320

attttaaaat atcaagagat cgtctcagtg cttcttccct tacaatggag agttttgctt   1380

ttctttgggc tggaggaaga gcatcctatg gtgtgtcaaa aggcaaagtg tgttttgaga   1440

tgaaggttac agagaagatc ccagtaaggc atttatatac aaaagatatt gacatacatg   1500

aagttcgtat tggctggtca ctaactacaa gtggaatgtt acttggtgaa gaagaatttt   1560

cttatgggta ttctctaaaa ggaataaaaa catgcaactg tgagactgaa gattatggag   1620

aaaagtttga tgaaaatgat gtgattacat gttttgctaa ctttgaaagt gatgaagtag   1680

aactctcgta tgctaagaat ggacaagatc ttggcgttgc cttcaaaatc agtaaggaag   1740

ttcttgctgg acggccactg ttcccgcatg ttctctgcca caactgtgca gttgaattta   1800

attttggtca gaaggaaaag ccatattttc caatacctga agagtatact ttcatccaga   1860

acgtcccctt agaggatcga gttagaggac caaaggggcc tgaagagaag aaagattgtg   1920

aagttgtgat gatgattggc ttgccaggag ctggaaaaac tacctgggtt actaaacatg   1980

cagcagaaaa tccagggaaa tataacattc ttggcacaaa tactattatg gataagatga   2040

tggtggcagg ttttaagaag caaatggcag atactggaaa actgaacaca ctgttgcaga   2100

gagcccccca gtgtcttggg aaatttattg agattgctgc ccgaaagaag cgaaatttta   2160

ttctggatca gacaaatgtg tctgctgctg cccagaggag aaaaatgtgc ctgtttgcag   2220

gcttccagcg aaaagctgtt gtagtttgcc caaaagatga agactataag caaagaacac   2280

agaagaaagc agaagtagag gggaaagacc taccagaaca tgcggtcctc aaaatgaaag   2340

gaaactttac cctcccagag gtagctgagt gctttgatga aataacctat gttgaacttc   2400

agaaggaaga agcccaaaaa ctcttggagc aatataagga agaaagcaaa aaggctcttc   2460

caccagaaaa gaaacagaac actggctcaa agaaaagcaa taaaaataag agtggcaaga   2520

accagtttaa cagaggtggt ggccatagag gacgtggagg attcaatatg cgtggtggaa   2580

atttcagagg aggaggcaac ccctgggaat cgtggcggat ataataggag gggcaacatg   2640

ccacagagag gtggtggcgg tggaggaagt ggtggaatcg gctatccata ccctcgtgcc   2700

cctgtttttc ctggccgtgg tagttactca aacagaggga actacaacag aggtggaatg   2760

cccaacagag ggaactacaa ccagaacttc agaggacgag gaaacaatcg tggctacaaa   2820

aatcaatctc agggctacaa ccagtggcag cagggtcaat tctggggtca gaagccatgg   2880

agtcagcatt atcaccaagg atattattga atacccaaat aaaacgaact gatacatatt   2940

tctccaaaac cttcacaaga agtcgactgt tttctttagt aggctaactt tttaaacatt   3000

ccacaagagg aagtgcctgc gggttccttt tttagaagct ttgtgggttg attttttttc   3060

ttttcttttt tgtacatttt taattgcagt ttaaaagtga atcgtaagag aacctcagca   3120

ttgtgcacga taagagaatg tgtcagtatt tcagggttct acattttatc tgtaaaatgt   3180

gacttttttt tttttttatc acaacagaag taaaatgttg ctttgtacct ggtgtctttt   3240

attaagaatt tactcccccc atttctcaca gagaataaca gtcgggagtc attgtcacaa   3300

tataatagaa atgttagcaa ccagattcat gtaaggacta agtggtcctc atgaattgca   3360

ttaagactct gtactgctca tattacactc catcctctct gtagtttgct gggtagtgga   3420

gggggtaagc taaatcatag tttctgacaa taactgggaa ggttttttct taaaataaca   3480

atggaattgg tataattggg attgaaaact aaaacttgga actaagatag agaagatgga   3540

gtgtatgtag aagggctgtt aaaaatgtaa aacttggttg cattatttgt ggaggctcaa   3600

acttgtgaag gttaatacca taatttttcc atttgttctg cattttgatt ctgaaaagaa   3660

agctggcttt gcccatttct tattaaaaaa acttgttgta aatccagttg tctaatggga   3720

tctatatgaa gttagccatg tctgtatgcc cttctcccac aaaatactgt ataactagtg   3780

tgcttgtagt agttaactcc accatctttg taagctaatg aaattgtgag tcacccattt   3840

atatcttaat ttttaatcat gtcagttctt gaatgggtat ctccttagcc tgctgatttc   3900

tttttctttc taaagaaagt gggtggagaa attaatttag acgtttgttt gcaataaaaa   3960

gaattcattt tactcttgtt ttgggattct cgccatcaag gttcaaaatc cctttatata   4020

actcccaaga ggagaaattt attaagtgtg tgctttctgg acagcttatt ctttactctg   4080

catagaacat ttaggtttta aaaacttaaa tgtatactga caattgatac ataattatga   4140

agtaaagttg aattcttccc ttcccctccc ccccagacaa cttttaacat atttaatgag   4200

gggaaaaggt actggctggg agaagttaac actgagttta tcatctttac agaatgctaa   4260

tgctgtcctc aactgattat tttatataca tatatatgat acatgaaact ctgggatcag   4320

atgcttttag aagccatcat gcaagccagt cattgatgtc actgctacac aacactgcta   4380

acttgactgt agctatgtaa taacattaga tcccctaatt gtaattatat tgggtttgca   4440

cagaacactt taatcttccc ctcaccaatg tgaagtgagg aatcaggagt caaactgtag   4500

aactaaaatt tgacttcagt ctagcgtttc cttggtgttt ttaggttgct ttggtaagtt   4560

taggtttgct atatttctga ttgcttagaa ttttgtttta gccctttaaa atcagatcat   4620

aaatatgaat tcatacttct aaggaatttt cttgctataa gctggagttt aggtgatgta   4680

taggttcagt tgagacattt ttggaacagg caaatcctta gttaacataa gatatttaac   4740

agttgaagat agtgtcatgg atttttatct tttttagcaa gtaatgctaa gaaccactgg   4800

cctgagctac tactcttcag tatacattat taggattgca tagacttact agaggaacag   4860

tttcaggttt tgatgctaat cagtgttgtg tcctaaagtt gtcctttgtg cctttaaaaa   4920

gttttggata tatcttctag tttaaaattg cttattaagg aattcatttt ataattgcag   4980

tgggaaagta atggtcaagt aacactaggt agactatcat gcctgtttag cccagagaat   5040

ttggggggag agagaataga taaaaatggc acccagaaaa atgttaaaat ctttagtcaa   5100

gactagaatt aatacaattg tctacacttg tatggcagaa ataaccttat aaagtgttta   5160

aggaattcag agaagggaat gtaccaaata agcaacaggg agaaaattag gtaagaagta   5220

agatacgaac gagaaacctg atttattgct catccttccc ttgcctccct aatggcaagc   5280

aaaactctga acatctgaaa aggatgtagt tctggacaaa tcctgactac ccagaggaaa   5340

ctcactgtga gattgctgtt gatttgaagg gtgctttcac taaggttata ttttaaagta   5400

gaataacaca tgctgagtgt aaactggctt tggattggtc agctgcagta gtacaaaaac   5460

agcatagaat ttgagaaaac taaaactgct atgagatagc tatgagaaaa ctaaaactgc   5520

tatgagatag aaatgatgta aaattatgtg gaaagttttc cctcatatac tcacatacag   5580

cctttgaagg gctctggctc tgaccggttg atggccttga gcgagatgaa atcatgaaat   5640

tgagtcaaat caatttgaca ttgaaatgac aagaggaaac tcttaaatac ataaaaacaa   5700

gctctcattt gcctaggata gatactgtct taaaaataaa gactgaacct agatgttctg   5760

agcactagca acaaggtatt ttaacaagtt taaaggaatt ctctgaaaaa gttataaaat   5820

tattctagga aacataacca taatagtgtt ttaagggact ttcacctggg gattttatat   5880

tcatgaacag agtgtattct gtatttaaaa tgtctcattt gtgggaattg gatgacatgt   5940

tttttgataa atttattcac aatataaatt gactttttat tctaggacca tgtgaataat   6000

gggttccatt gcacaaatac aaatatttta atagcttctt aggcagtggt gtagacatct   6060

tggatataaa taattgtaga tcttgtatat ttgattttta aaaaactaga ataaacagag   6120

aggcataaac atatcttaga gtccaagtgg tagtgtttag cattggatat aataaatgga   6180

tgttttacaa agtgtttcca taattctctt cctatacata aatgtcttgt tttcaaaagt   6240

ggatggaact tggctgggtg tggtggctca cgcctgtaat cctagcactt tgggaggcca   6300

aggcgggagg atcacttgag ctcaggagtt tgagaccatc ctgggcaaca tagtgagacc   6360

tggtctcttg aaaaaaaaaa agtggatgga acttgtagca gagaatttta tctacttctc   6420

aacctgcttc agaataccca tttgagatgt tcccctggaa agatgaacac aatactgcat   6480

ctgaagccat ttcttcccac ctaacattct taaaatgatt agagtctaaa ctttgtcatt   6540

cattcctaat tctggagctc tgaggttgag gtgttcagag tttggtgaat aattgggttt   6600

aagttttaac attttagtaa taataaaagc aaacacatac atgttaaggc ctgacaatag   6660

gttgcaatac ccatgcattg ggactcatac ccagcataaa tggtgaggga ctgaacatta   6720

gtgctttgag caagaattgg ttaactacct gagatctcta aaacagtaat ttgaattact   6780

aatacataaa ccacaagtct cttcgaattg ttaattgcct aaatttaccc taaaacttag   6840

ttaacgctgc agtgccttta ttaaagcttt tttttggggg ggggtgtggg cacagctact   6900

ccataacttt aaattttaaa gcatgaaggt gatctagcta gtgttagtgc ttgagttggt   6960

agttacatag gctgctcttg aatcgtcctg ttttctttgc ctagtattag caccacaggt   7020

acatatttgt aaaataagca ttaaaagtac tttgtccagc taactcatgt tggagtgacc   7080

tttgtcttac taacctttgt tactaaactt gttaattaga ataagccctt gagaatttgg   7140

aagtgagcta tactactaat gtagtatata tctcttgagt gtgttggagt agatgaaaaa   7200

ccaggggtcc ccaagggtat atttttgaaa ttgaacagaa acaattcatc ttaatattta   7260

gttttcatta tgtttagctt aatatgtgtg ctagtttatt tggcgtcaca cttatgtcaa   7320

tctcaagtca tgcagaaata gcacagtctc agaaaagagg ttaggtggga aatagatgat   7380

atgcttacat tattgagcag gactatgctt tcacatccta accaattgac taaaaatata   7440

aatgattgaa gtaattttca ttagttgccc caggagtctt taataatagt tttaagggat   7500

agtagattgg acatagatag atgggttatt cataatggat attcataatg gatattcata   7560

atgttaacct agaattattc agaaaatata acacctatgt agtagaatct attgattgta   7620

agcctagtgt tggtaggcaa acatgttgat gatgggccag gacatcagta atcactactt   7680

ggttaggcaa gtaattagga cagggattgt aatcatgtca atttgtagct acctaatttt   7740

tattgattag gatactttat ttttcatgcc aggattcagc atatacttag gtcttgagca   7800

ggggctttgc ttttaaagct gaatcctggg cataagaagc tatgtactgt agttgaaagt   7860

gaagtaaatg tcaatgtagg ctagtctcta gagaaatgtc ttct                    7904


<210>  2091
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  2091

Met Glu Ser Phe Ala Phe Leu Trp Ala Gly Gly Arg Ala Ser Tyr Gly 
1               5                   10                  15


Val Ser Lys Gly Lys Val Cys Phe Glu Met Lys Val Thr Glu Lys Ile 
            20                  25                  30


Pro Val Arg His Leu Tyr Thr Lys Asp Ile Asp Ile His Glu Val Arg 
        35                  40                  45


Ile Gly Trp Ser Leu Thr Thr Ser Gly Met Leu Leu Gly Glu Glu Glu 
    50                  55                  60


Phe Ser Tyr Gly Tyr Ser Leu Lys Gly Ile Lys Thr Cys Asn Cys Glu 
65                  70                  75                  80


Thr Glu Asp Tyr Gly Glu Lys Phe Asp Glu Asn Asp Val Ile Thr Cys 
                85                  90                  95


Phe Ala Asn Phe Glu Ser Asp Glu Val Glu Leu Ser Tyr Ala Lys Asn 
            100                 105                 110


Gly Gln Asp Leu Gly Val Ala Phe Lys Ile Ser Lys Glu Val Leu Ala 
        115                 120                 125


Gly Arg Pro Leu Phe Pro His Val Leu Cys His Asn Cys Ala Val Glu 
    130                 135                 140


Phe Asn Phe Gly Gln Lys Glu Lys Pro Tyr Phe Pro Ile Pro Glu Glu 
145                 150                 155                 160


Tyr Thr Phe Ile Gln Asn Val Pro Leu Glu Asp Arg Val Arg Gly Pro 
                165                 170                 175


Lys Gly Pro Glu Glu Lys Lys Asp Cys Glu Val Val Met Met Ile Gly 
            180                 185                 190


Leu Pro Gly Ala Gly Lys Thr Thr Trp Val Thr Lys His Ala Ala Glu 
        195                 200                 205


Asn Pro Gly Lys Tyr Asn Ile Leu Gly Thr Asn Thr Ile Met Asp Lys 
    210                 215                 220


Met Met Val Ala Gly Phe Lys Lys Gln Met Ala Asp Thr Gly Lys Leu 
225                 230                 235                 240


Asn Thr Leu Leu Gln Arg Ala Pro Gln Cys Leu Gly Lys Phe Ile Glu 
                245                 250                 255


Ile Ala Ala Arg Lys Lys Arg Asn Phe Ile Leu Asp Gln Thr Asn Val 
            260                 265                 270


Ser Ala Ala Ala Gln Arg Arg Lys Met Cys Leu Phe Ala Gly Phe Gln 
        275                 280                 285


Arg Lys Ala Val Val Val Cys Pro Lys Asp Glu Asp Tyr Lys Gln Arg 
    290                 295                 300


Thr Gln Lys Lys Ala Glu Val Glu Gly Lys Asp Leu Pro Glu His Ala 
305                 310                 315                 320


Val Leu Lys Met Lys Gly Asn Phe Thr Leu Pro Glu Val Ala Glu Cys 
                325                 330                 335


Phe Asp Glu Ile Thr Tyr Val Glu Leu Gln Lys Glu Glu Ala Gln Lys 
            340                 345                 350


Leu Leu Glu Gln Tyr Lys Glu Glu Ser Lys Lys Ala Leu Pro Pro Glu 
        355                 360                 365


Lys Lys Gln Asn Thr Gly Ser Lys Lys Ser Asn Lys Asn Lys Ser Gly 
    370                 375                 380


Lys Asn Gln Phe Asn Arg Gly Gly Gly His Arg Gly Arg Gly Gly Phe 
385                 390                 395                 400


Asn Met Arg Gly Gly Asn Phe Arg Gly Gly Gly Asn Pro Trp Glu Ser 
                405                 410                 415


Trp Arg Ile 



<210>  2092
<211>  5859
<212>  DNA
<213>  Homo sapiens

<400>  2092
acgaagagct ggagaaacac ataagaaggc agatctaaga tggaagaaaa ggcggattcg     60

ggttgaaacg ccaagttgag gactgaagaa agcatttgga taaagcagcc tccaagctgg    120

gaaggagaaa agccaaacga gtatagccac caaagaccca gaaaggccaa tatatcatgc    180

agtgagtcgg ttgaactgaa aggcggtttc cttttcctcc atttgctcag tcccaattgg    240

aagcgcactg cgcggcctcc accgcgctct cggcccgggt tcggcgtggg ggcggggagg    300

taagtacggt aatgggcggg gccgagcgcg ggcgcgctcc ggctttcctc ctgcgcagtg    360

ctcccgtcag cgcagggggc ggggcgccta tattacgtgc gcggcgccgc tcctgcgaga    420

ggacgttgcg tgctcgctcg cgccaggcga gtctccgcgt ctccctcgcg aactcggtga    480

aaggaattgg cgccgttcga caccaggcgg atccgctctg cagcacgaac ccatctccag    540

ccgcagccgc agcccccctg ggaatcgtgg cggatataat aggaggggca acatgccaca    600

gagaggtggt ggcggtggag gaagtggtgg aatcggctat ccataccctc gtgcccctgt    660

ttttcctggc cgtggtagtt actcaaacag agggaactac aacagaggtg gaatgcccaa    720

cagagggaac tacaaccaga acttcagagg acgaggaaac aatcgtggct acaaaaatca    780

atctcagggc tacaaccagt ggcagcaggg tcaattctgg ggtcagaagc catggagtca    840

gcattatcac caaggatatt attgaatacc caaataaaac gaactgatac atatttctcc    900

aaaaccttca caagaagtcg actgttttct ttagtaggct aactttttaa acattccaca    960

agaggaagtg cctgcgggtt ccttttttag aagctttgtg ggttgatttt ttttcttttc   1020

ttttttgtac atttttaatt gcagtttaaa agtgaatcgt aagagaacct cagcattgtg   1080

cacgataaga gaatgtgtca gtatttcagg gttctacatt ttatctgtaa aatgtgactt   1140

tttttttttt ttatcacaac agaagtaaaa tgttgctttg tacctggtgt cttttattaa   1200

gaatttactc cccccatttc tcacagagaa taacagtcgg gagtcattgt cacaatataa   1260

tagaaatgtt agcaaccaga ttcatgtaag gactaagtgg tcctcatgaa ttgcattaag   1320

actctgtact gctcatatta cactccatcc tctctgtagt ttgctgggta gtggaggggg   1380

taagctaaat catagtttct gacaataact gggaaggttt tttcttaaaa taacaatgga   1440

attggtataa ttgggattga aaactaaaac ttggaactaa gatagagaag atggagtgta   1500

tgtagaaggg ctgttaaaaa tgtaaaactt ggttgcatta tttgtggagg ctcaaacttg   1560

tgaaggttaa taccataatt tttccatttg ttctgcattt tgattctgaa aagaaagctg   1620

gctttgccca tttcttatta aaaaaacttg ttgtaaatcc agttgtctaa tgggatctat   1680

atgaagttag ccatgtctgt atgcccttct cccacaaaat actgtataac tagtgtgctt   1740

gtagtagtta actccaccat ctttgtaagc taatgaaatt gtgagtcacc catttatatc   1800

ttaattttta atcatgtcag ttcttgaatg ggtatctcct tagcctgctg atttcttttt   1860

ctttctaaag aaagtgggtg gagaaattaa tttagacgtt tgtttgcaat aaaaagaatt   1920

cattttactc ttgttttggg attctcgcca tcaaggttca aaatcccttt atataactcc   1980

caagaggaga aatttattaa gtgtgtgctt tctggacagc ttattcttta ctctgcatag   2040

aacatttagg ttttaaaaac ttaaatgtat actgacaatt gatacataat tatgaagtaa   2100

agttgaattc ttcccttccc ctccccccca gacaactttt aacatattta atgaggggaa   2160

aaggtactgg ctgggagaag ttaacactga gtttatcatc tttacagaat gctaatgctg   2220

tcctcaactg attattttat atacatatat atgatacatg aaactctggg atcagatgct   2280

tttagaagcc atcatgcaag ccagtcattg atgtcactgc tacacaacac tgctaacttg   2340

actgtagcta tgtaataaca ttagatcccc taattgtaat tatattgggt ttgcacagaa   2400

cactttaatc ttcccctcac caatgtgaag tgaggaatca ggagtcaaac tgtagaacta   2460

aaatttgact tcagtctagc gtttccttgg tgtttttagg ttgctttggt aagtttaggt   2520

ttgctatatt tctgattgct tagaattttg ttttagccct ttaaaatcag atcataaata   2580

tgaattcata cttctaagga attttcttgc tataagctgg agtttaggtg atgtataggt   2640

tcagttgaga catttttgga acaggcaaat ccttagttaa cataagatat ttaacagttg   2700

aagatagtgt catggatttt tatctttttt agcaagtaat gctaagaacc actggcctga   2760

gctactactc ttcagtatac attattagga ttgcatagac ttactagagg aacagtttca   2820

ggttttgatg ctaatcagtg ttgtgtccta aagttgtcct ttgtgccttt aaaaagtttt   2880

ggatatatct tctagtttaa aattgcttat taaggaattc attttataat tgcagtggga   2940

aagtaatggt caagtaacac taggtagact atcatgcctg tttagcccag agaatttggg   3000

gggagagaga atagataaaa atggcaccca gaaaaatgtt aaaatcttta gtcaagacta   3060

gaattaatac aattgtctac acttgtatgg cagaaataac cttataaagt gtttaaggaa   3120

ttcagagaag ggaatgtacc aaataagcaa cagggagaaa attaggtaag aagtaagata   3180

cgaacgagaa acctgattta ttgctcatcc ttcccttgcc tccctaatgg caagcaaaac   3240

tctgaacatc tgaaaaggat gtagttctgg acaaatcctg actacccaga ggaaactcac   3300

tgtgagattg ctgttgattt gaagggtgct ttcactaagg ttatatttta aagtagaata   3360

acacatgctg agtgtaaact ggctttggat tggtcagctg cagtagtaca aaaacagcat   3420

agaatttgag aaaactaaaa ctgctatgag atagctatga gaaaactaaa actgctatga   3480

gatagaaatg atgtaaaatt atgtggaaag ttttccctca tatactcaca tacagccttt   3540

gaagggctct ggctctgacc ggttgatggc cttgagcgag atgaaatcat gaaattgagt   3600

caaatcaatt tgacattgaa atgacaagag gaaactctta aatacataaa aacaagctct   3660

catttgccta ggatagatac tgtcttaaaa ataaagactg aacctagatg ttctgagcac   3720

tagcaacaag gtattttaac aagtttaaag gaattctctg aaaaagttat aaaattattc   3780

taggaaacat aaccataata gtgttttaag ggactttcac ctggggattt tatattcatg   3840

aacagagtgt attctgtatt taaaatgtct catttgtggg aattggatga catgtttttt   3900

gataaattta ttcacaatat aaattgactt tttattctag gaccatgtga ataatgggtt   3960

ccattgcaca aatacaaata ttttaatagc ttcttaggca gtggtgtaga catcttggat   4020

ataaataatt gtagatcttg tatatttgat ttttaaaaaa ctagaataaa cagagaggca   4080

taaacatatc ttagagtcca agtggtagtg tttagcattg gatataataa atggatgttt   4140

tacaaagtgt ttccataatt ctcttcctat acataaatgt cttgttttca aaagtggatg   4200

gaacttggct gggtgtggtg gctcacgcct gtaatcctag cactttggga ggccaaggcg   4260

ggaggatcac ttgagctcag gagtttgaga ccatcctggg caacatagtg agacctggtc   4320

tcttgaaaaa aaaaaagtgg atggaacttg tagcagagaa ttttatctac ttctcaacct   4380

gcttcagaat acccatttga gatgttcccc tggaaagatg aacacaatac tgcatctgaa   4440

gccatttctt cccacctaac attcttaaaa tgattagagt ctaaactttg tcattcattc   4500

ctaattctgg agctctgagg ttgaggtgtt cagagtttgg tgaataattg ggtttaagtt   4560

ttaacatttt agtaataata aaagcaaaca catacatgtt aaggcctgac aataggttgc   4620

aatacccatg cattgggact catacccagc ataaatggtg agggactgaa cattagtgct   4680

ttgagcaaga attggttaac tacctgagat ctctaaaaca gtaatttgaa ttactaatac   4740

ataaaccaca agtctcttcg aattgttaat tgcctaaatt taccctaaaa cttagttaac   4800

gctgcagtgc ctttattaaa gctttttttt gggggggggt gtgggcacag ctactccata   4860

actttaaatt ttaaagcatg aaggtgatct agctagtgtt agtgcttgag ttggtagtta   4920

cataggctgc tcttgaatcg tcctgttttc tttgcctagt attagcacca caggtacata   4980

tttgtaaaat aagcattaaa agtactttgt ccagctaact catgttggag tgacctttgt   5040

cttactaacc tttgttacta aacttgttaa ttagaataag cccttgagaa tttggaagtg   5100

agctatacta ctaatgtagt atatatctct tgagtgtgtt ggagtagatg aaaaaccagg   5160

ggtccccaag ggtatatttt tgaaattgaa cagaaacaat tcatcttaat atttagtttt   5220

cattatgttt agcttaatat gtgtgctagt ttatttggcg tcacacttat gtcaatctca   5280

agtcatgcag aaatagcaca gtctcagaaa agaggttagg tgggaaatag atgatatgct   5340

tacattattg agcaggacta tgctttcaca tcctaaccaa ttgactaaaa atataaatga   5400

ttgaagtaat tttcattagt tgccccagga gtctttaata atagttttaa gggatagtag   5460

attggacata gatagatggg ttattcataa tggatattca taatggatat tcataatgtt   5520

aacctagaat tattcagaaa atataacacc tatgtagtag aatctattga ttgtaagcct   5580

agtgttggta ggcaaacatg ttgatgatgg gccaggacat cagtaatcac tacttggtta   5640

ggcaagtaat taggacaggg attgtaatca tgtcaatttg tagctaccta atttttattg   5700

attaggatac tttatttttc atgccaggat tcagcatata cttaggtctt gagcaggggc   5760

tttgctttta aagctgaatc ctgggcataa gaagctatgt actgtagttg aaagtgaagt   5820

aaatgtcaat gtaggctagt ctctagagaa atgtcttct                          5859


<210>  2093
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  2093

Met Gly Gly Ala Glu Arg Gly Arg Ala Pro Ala Phe Leu Leu Arg Ser 
1               5                   10                  15


Ala Pro Val Ser Ala Gly Gly Gly Ala Pro Ile Leu Arg Ala Arg Arg 
            20                  25                  30


Arg Ser Cys Glu Arg Thr Leu Arg Ala Arg Ser Arg Gln Ala Ser Leu 
        35                  40                  45


Arg Val Ser Leu Ala Asn Ser Val Lys Gly Ile Gly Ala Val Arg His 
    50                  55                  60


Gln Ala Asp Pro Leu Cys Ser Thr Asn Pro Ser Pro Ala Ala Ala Ala 
65                  70                  75                  80


Ala Pro Leu Gly Ile Val Ala Asp Ile Ile Gly Gly Ala Thr Cys His 
                85                  90                  95


Arg Glu Val Val Ala Val Glu Glu Val Val Glu Ser Ala Ile His Thr 
            100                 105                 110


Leu Val Pro Leu Phe Phe Leu Ala Val Val Val Thr Gln Thr Glu Gly 
        115                 120                 125


Thr Thr Thr Glu Val Glu Cys Pro Thr Glu Gly Thr Thr Thr Arg Thr 
    130                 135                 140


Ser Glu Asp Glu Glu Thr Ile Val Ala Thr Lys Ile Asn Leu Arg Ala 
145                 150                 155                 160


Thr Thr Ser Gly Ser Arg Val Asn Ser Gly Val Arg Ser His Gly Val 
                165                 170                 175


Ser Ile Ile Thr Lys Asp Ile Ile Glu Tyr Pro Asn Lys Thr Asn 
            180                 185                 190


<210>  2094
<211>  7943
<212>  DNA
<213>  Homo sapiens

<400>  2094
acgaagagct ggagaaacac ataagaaggc agatctaaga tggaagaaaa ggcggattcg     60

ggttgaaacg ccaagttgag gactgaagaa agcatttgga taaagcagcc tccaagctgg    120

gaaggagaaa agccaaacga gtatagccac caaagaccca gaaaggccaa tatatcatgc    180

agtgagtcgg ttgaactgaa aggcggtttc cttttcctcc atttgctcag tcccaattgg    240

aagcgcactg cgcggcctcc accgcgctct cggcccgggt tcggcgtggg ggcggggagg    300

taagtacggt aatgggcggg gccgagcgcg ggcgcgctcc ggctttcctc ctgcgcagtg    360

ctcccgtcag cgcagggggc ggggcgccta tattacgtgc gcggcgccgc tcctgcgaga    420

ggacgttgcg tgctcgctcg cgccaggcga gtctccgcgt ctccctcgcg aactcggtga    480

aaggaattgg cgccgttcga caccaggcgg atccgctctg cagcacgaac ccatctccag    540

ccgcagccgc agccgccgcc cgggccgagg agcagccgca gcagccgcca ccagtggccg    600

agtgagcgga gccgagtttg aggcagcgcc tagcggtgaa tcggggccct caccatgagt    660

tcctcgcctg ttaatgtaaa aaagctgaag gtgtcggagc tgaaagagga gctcaagaag    720

cgacgccttt ctgacaaggg tctcaaggcc gagctcatgg agcgactcca ggctgcgctg    780

gacgacgagg aggccggggg ccgccccgcc atggagcccg ggaacggcag cctagacctg    840

ggcggggatt ccgctgggcg ctcgggagca ggcctcgagc aggaggccgc ggccggcggc    900

gatgaagagg aggaggaaga ggaagaggag gaggaaggaa tctccgctct ggacggcgac    960

cagatggagc taggagagga gaacggggcc gcgggggcgg ccgactcggg cccgatggag   1020

gaggaggagg ccgcctcgga agacgagaac ggcgacgatc agggtttcca ggaaggggaa   1080

gatgagctcg gggacgaaga ggaaggcgcg ggcgacgaga acgggcacgg ggagcagcag   1140

cctcaaccgc cggcgacgca gcagcaacag ccccaacagc agcgcggggc cgccaaggag   1200

gccgcgggga agagcagcgg ccccacctcg ctgttcgcgg tgacggtggc gccgcccggg   1260

gcgaggcagg gccagcagca ggcgggaggg gacggcaaaa cagaacagaa aggcggagat   1320

aaaaagaggg gtgttaaaag accacgagaa gatcatggcc gtggatattt tgagtacatt   1380

gaagagaaca agtatagcag agccaaatct cctcagccac ctgttgaaga agaagatgaa   1440

cacttcgatg acacagtggt ttgtcttgat acttataatt gtgatctaca ttttaaaata   1500

tcaagagatc gtctcagtgc ttcttccctt acaatggaga gttttgcttt tctttgggct   1560

ggaggaagag catcctatgg tgtgtcaaaa ggcaaagtgt gttttgagat gaaggttaca   1620

gagaagatcc cagtaaggca tttatataca aaagatattg acatacatga agttcgtatt   1680

ggctggtcac taactacaag tggaatgtta cttggtgaag aagaattttc ttatgggtat   1740

tctctaaaag gaataaaaac atgcaactgt gagactgaag attatggaga aaagtttgat   1800

gaaaatgatg tgattacatg ttttgctaac tttgaaagtg atgaagtaga actctcgtat   1860

gctaagaatg gacaagatct tggcgttgcc ttcaaaatca gtaaggaagt tcttgctgga   1920

cggccactgt tcccgcatgt tctctgccac aactgtgcag ttgaatttaa ttttggtcag   1980

aaggaaaagc catattttcc aatacctgaa gagtatactt tcatccagaa cgtcccctta   2040

gaggatcgag ttagaggacc aaaggggcct gaagagaaga aagattgtga agttgtgatg   2100

atgattggct tgccaggagc tggaaaaact acctgggtta ctaaacatgc agcagaaaat   2160

ccagggaaat ataacattct tggcacaaat actattatgg ataagatgat ggtggcaggt   2220

tttaagaagc aaatggcaga tactggaaaa ctgaacacac tgttgcagag agccccccag   2280

tgtcttggga aatttattga gattgctgcc cgaaagaagc gaaattttat tctggatcag   2340

acaaatgtgt ctgctgctgc ccagaggaga aaaatgtgcc tgtttgcagg cttccagcga   2400

aaagctgttg tagtttgccc aaaagatgaa gactataagc aaagaacaca gaagaaagca   2460

gaagtagagg ggaaagacct accagaacat gcggtcctca aaatgaaagg aaactttacc   2520

ctcccagagg tagctgagtg ctttgatgaa ataacctatg ttgaacttca gaaggaagaa   2580

gcccaaaaac tcttggagca atataaggaa gaaagcaaaa aggctcttcc accagaaaag   2640

aaacagaaca ctggctcaaa gaaaagcaat aaaaataaga gtggcaagaa ccagtttaac   2700

agaggtggtg gccatagagg acgtggagga ttcaatatgc gtggtggaaa tttcagagga   2760

ggaggcaacc cctgggaatc gtggcggata taataggagg ggcaacatgc cacagagagg   2820

tggtggcggt ggaggaagtg gtggaatcgg ctatccatac cctcgtgccc ctgtttttcc   2880

tggccgtggt agttactcaa acagagggaa ctacaacaga ggtggaatgc ccaacagagg   2940

gaactacaac cagaacttca gaggacgagg aaacaatcgt ggctacaaaa atcaatctca   3000

gggctacaac cagtggcagc agggtcaatt ctggggtcag aagccatgga gtcagcatta   3060

tcaccaagga tattattgaa tacccaaata aaacgaactg atacatattt ctccaaaacc   3120

ttcacaagaa gtcgactgtt ttctttagta ggctaacttt ttaaacattc cacaagagga   3180

agtgcctgcg ggttcctttt ttagaagctt tgtgggttga ttttttttct tttctttttt   3240

gtacattttt aattgcagtt taaaagtgaa tcgtaagaga acctcagcat tgtgcacgat   3300

aagagaatgt gtcagtattt cagggttcta cattttatct gtaaaatgtg actttttttt   3360

ttttttatca caacagaagt aaaatgttgc tttgtacctg gtgtctttta ttaagaattt   3420

actcccccca tttctcacag agaataacag tcgggagtca ttgtcacaat ataatagaaa   3480

tgttagcaac cagattcatg taaggactaa gtggtcctca tgaattgcat taagactctg   3540

tactgctcat attacactcc atcctctctg tagtttgctg ggtagtggag ggggtaagct   3600

aaatcatagt ttctgacaat aactgggaag gttttttctt aaaataacaa tggaattggt   3660

ataattggga ttgaaaacta aaacttggaa ctaagataga gaagatggag tgtatgtaga   3720

agggctgtta aaaatgtaaa acttggttgc attatttgtg gaggctcaaa cttgtgaagg   3780

ttaataccat aatttttcca tttgttctgc attttgattc tgaaaagaaa gctggctttg   3840

cccatttctt attaaaaaaa cttgttgtaa atccagttgt ctaatgggat ctatatgaag   3900

ttagccatgt ctgtatgccc ttctcccaca aaatactgta taactagtgt gcttgtagta   3960

gttaactcca ccatctttgt aagctaatga aattgtgagt cacccattta tatcttaatt   4020

tttaatcatg tcagttcttg aatgggtatc tccttagcct gctgatttct ttttctttct   4080

aaagaaagtg ggtggagaaa ttaatttaga cgtttgtttg caataaaaag aattcatttt   4140

actcttgttt tgggattctc gccatcaagg ttcaaaatcc ctttatataa ctcccaagag   4200

gagaaattta ttaagtgtgt gctttctgga cagcttattc tttactctgc atagaacatt   4260

taggttttaa aaacttaaat gtatactgac aattgataca taattatgaa gtaaagttga   4320

attcttccct tcccctcccc cccagacaac ttttaacata tttaatgagg ggaaaaggta   4380

ctggctggga gaagttaaca ctgagtttat catctttaca gaatgctaat gctgtcctca   4440

actgattatt ttatatacat atatatgata catgaaactc tgggatcaga tgcttttaga   4500

agccatcatg caagccagtc attgatgtca ctgctacaca acactgctaa cttgactgta   4560

gctatgtaat aacattagat cccctaattg taattatatt gggtttgcac agaacacttt   4620

aatcttcccc tcaccaatgt gaagtgagga atcaggagtc aaactgtaga actaaaattt   4680

gacttcagtc tagcgtttcc ttggtgtttt taggttgctt tggtaagttt aggtttgcta   4740

tatttctgat tgcttagaat tttgttttag ccctttaaaa tcagatcata aatatgaatt   4800

catacttcta aggaattttc ttgctataag ctggagttta ggtgatgtat aggttcagtt   4860

gagacatttt tggaacaggc aaatccttag ttaacataag atatttaaca gttgaagata   4920

gtgtcatgga tttttatctt ttttagcaag taatgctaag aaccactggc ctgagctact   4980

actcttcagt atacattatt aggattgcat agacttacta gaggaacagt ttcaggtttt   5040

gatgctaatc agtgttgtgt cctaaagttg tcctttgtgc ctttaaaaag ttttggatat   5100

atcttctagt ttaaaattgc ttattaagga attcatttta taattgcagt gggaaagtaa   5160

tggtcaagta acactaggta gactatcatg cctgtttagc ccagagaatt tggggggaga   5220

gagaatagat aaaaatggca cccagaaaaa tgttaaaatc tttagtcaag actagaatta   5280

atacaattgt ctacacttgt atggcagaaa taaccttata aagtgtttaa ggaattcaga   5340

gaagggaatg taccaaataa gcaacaggga gaaaattagg taagaagtaa gatacgaacg   5400

agaaacctga tttattgctc atccttccct tgcctcccta atggcaagca aaactctgaa   5460

catctgaaaa ggatgtagtt ctggacaaat cctgactacc cagaggaaac tcactgtgag   5520

attgctgttg atttgaaggg tgctttcact aaggttatat tttaaagtag aataacacat   5580

gctgagtgta aactggcttt ggattggtca gctgcagtag tacaaaaaca gcatagaatt   5640

tgagaaaact aaaactgcta tgagatagct atgagaaaac taaaactgct atgagataga   5700

aatgatgtaa aattatgtgg aaagttttcc ctcatatact cacatacagc ctttgaaggg   5760

ctctggctct gaccggttga tggccttgag cgagatgaaa tcatgaaatt gagtcaaatc   5820

aatttgacat tgaaatgaca agaggaaact cttaaataca taaaaacaag ctctcatttg   5880

cctaggatag atactgtctt aaaaataaag actgaaccta gatgttctga gcactagcaa   5940

caaggtattt taacaagttt aaaggaattc tctgaaaaag ttataaaatt attctaggaa   6000

acataaccat aatagtgttt taagggactt tcacctgggg attttatatt catgaacaga   6060

gtgtattctg tatttaaaat gtctcatttg tgggaattgg atgacatgtt ttttgataaa   6120

tttattcaca atataaattg actttttatt ctaggaccat gtgaataatg ggttccattg   6180

cacaaataca aatattttaa tagcttctta ggcagtggtg tagacatctt ggatataaat   6240

aattgtagat cttgtatatt tgatttttaa aaaactagaa taaacagaga ggcataaaca   6300

tatcttagag tccaagtggt agtgtttagc attggatata ataaatggat gttttacaaa   6360

gtgtttccat aattctcttc ctatacataa atgtcttgtt ttcaaaagtg gatggaactt   6420

gtggatggaa cttgtagcag agaattttat ctacttctca acctgcttca gaatacccat   6480

ttgagatgtt cccctggaaa gatgaacaca atactgcatc tgaagccatt tcttcccacc   6540

taacattctt aaaatgatta gagtctaaac tttgtcattc attcctaatt ctggagctct   6600

gaggttgagg tgttcagagt ttggtgaata attgggttta agttttaaca ttttagtaat   6660

aataaaagca aacacataca tgttaaggcc tgacaatagg ttgcaatacc catgcattgg   6720

gactcatacc cagcataaat ggtgagggac tgaacattag tgctttgagc aagaattggt   6780

taactacctg agatctctaa aacagtaatt tgaattacta atacataaac cacaagtctc   6840

ttcgaattgt taattgccta aatttaccct aaaacttagt taacgctgca gtgcctttat   6900

taaagctttt ttttgggggg gggtgtgggc acagctactc cataacttta aattttaaag   6960

catgaaggtg atctagctag tgttagtgct tgagttggta gttacatagg ctgctcttga   7020

atcgtcctgt tttctttgcc tagtattagc accacaggta catatttgta aaataagcat   7080

taaaagtact ttgtccagct aactcatgtt ggagtgacct ttgtcttact aacctttgtt   7140

actaaacttg ttaattagaa taagcccttg agaatttgga agtgagctat actactaatg   7200

tagtatatat ctcttgagtg tgttggagta gatgaaaaac caggggtccc caagggtata   7260

tttttgaaat tgaacagaaa caattcatct taatatttag ttttcattat gtttagctta   7320

atatgtgtgc tagtttattt ggcgtcacac ttatgtcaat ctcaagtcat gcagaaatag   7380

cacagtctca gaaaagaggt taggtgggaa atagatgata tgcttacatt attgagcagg   7440

actatgcttt cacatcctaa ccaattgact aaaaatataa atgattgaag taattttcat   7500

tagttgcccc aggagtcttt aataatagtt ttaagggata gtagattgga catagataga   7560

tgggttattc ataatggata ttcataatgg atattcataa tgttaaccta gaattattca   7620

gaaaatataa cacctatgta gtagaatcta ttgattgtaa gcctagtgtt ggtaggcaaa   7680

catgttgatg atgggccagg acatcagtaa tcactacttg gttaggcaag taattaggac   7740

agggattgta atcatgtcaa tttgtagcta cctaattttt attgattagg atactttatt   7800

tttcatgcca ggattcagca tatacttagg tcttgagcag gggctttgct tttaaagctg   7860

aatcctgggc ataagaagct atgtactgta gttgaaagtg aagtaaatgt caatgtaggc   7920

tagtctctag agaaatgtct tct                                           7943


<210>  2095
<211>  712
<212>  PRT
<213>  Homo sapiens

<400>  2095

Met Ser Ser Ser Pro Val Asn Val Lys Lys Leu Lys Val Ser Glu Leu 
1               5                   10                  15


Lys Glu Glu Leu Lys Lys Arg Arg Leu Ser Asp Lys Gly Leu Lys Ala 
            20                  25                  30


Glu Leu Met Glu Arg Leu Gln Ala Ala Leu Asp Asp Glu Glu Ala Gly 
        35                  40                  45


Gly Arg Pro Ala Met Glu Pro Gly Asn Gly Ser Leu Asp Leu Gly Gly 
    50                  55                  60


Asp Ser Ala Gly Arg Ser Gly Ala Gly Leu Glu Gln Glu Ala Ala Ala 
65                  70                  75                  80


Gly Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ile 
                85                  90                  95


Ser Ala Leu Asp Gly Asp Gln Met Glu Leu Gly Glu Glu Asn Gly Ala 
            100                 105                 110


Ala Gly Ala Ala Asp Ser Gly Pro Met Glu Glu Glu Glu Ala Ala Ser 
        115                 120                 125


Glu Asp Glu Asn Gly Asp Asp Gln Gly Phe Gln Glu Gly Glu Asp Glu 
    130                 135                 140


Leu Gly Asp Glu Glu Glu Gly Ala Gly Asp Glu Asn Gly His Gly Glu 
145                 150                 155                 160


Gln Gln Pro Gln Pro Pro Ala Thr Gln Gln Gln Gln Pro Gln Gln Gln 
                165                 170                 175


Arg Gly Ala Ala Lys Glu Ala Ala Gly Lys Ser Ser Gly Pro Thr Ser 
            180                 185                 190


Leu Phe Ala Val Thr Val Ala Pro Pro Gly Ala Arg Gln Gly Gln Gln 
        195                 200                 205


Gln Ala Gly Gly Asp Gly Lys Thr Glu Gln Lys Gly Gly Asp Lys Lys 
    210                 215                 220


Arg Gly Val Lys Arg Pro Arg Glu Asp His Gly Arg Gly Tyr Phe Glu 
225                 230                 235                 240


Tyr Ile Glu Glu Asn Lys Tyr Ser Arg Ala Lys Ser Pro Gln Pro Pro 
                245                 250                 255


Val Glu Glu Glu Asp Glu His Phe Asp Asp Thr Val Val Cys Leu Asp 
            260                 265                 270


Thr Tyr Asn Cys Asp Leu His Phe Lys Ile Ser Arg Asp Arg Leu Ser 
        275                 280                 285


Ala Ser Ser Leu Thr Met Glu Ser Phe Ala Phe Leu Trp Ala Gly Gly 
    290                 295                 300


Arg Ala Ser Tyr Gly Val Ser Lys Gly Lys Val Cys Phe Glu Met Lys 
305                 310                 315                 320


Val Thr Glu Lys Ile Pro Val Arg His Leu Tyr Thr Lys Asp Ile Asp 
                325                 330                 335


Ile His Glu Val Arg Ile Gly Trp Ser Leu Thr Thr Ser Gly Met Leu 
            340                 345                 350


Leu Gly Glu Glu Glu Phe Ser Tyr Gly Tyr Ser Leu Lys Gly Ile Lys 
        355                 360                 365


Thr Cys Asn Cys Glu Thr Glu Asp Tyr Gly Glu Lys Phe Asp Glu Asn 
    370                 375                 380


Asp Val Ile Thr Cys Phe Ala Asn Phe Glu Ser Asp Glu Val Glu Leu 
385                 390                 395                 400


Ser Tyr Ala Lys Asn Gly Gln Asp Leu Gly Val Ala Phe Lys Ile Ser 
                405                 410                 415


Lys Glu Val Leu Ala Gly Arg Pro Leu Phe Pro His Val Leu Cys His 
            420                 425                 430


Asn Cys Ala Val Glu Phe Asn Phe Gly Gln Lys Glu Lys Pro Tyr Phe 
        435                 440                 445


Pro Ile Pro Glu Glu Tyr Thr Phe Ile Gln Asn Val Pro Leu Glu Asp 
    450                 455                 460


Arg Val Arg Gly Pro Lys Gly Pro Glu Glu Lys Lys Asp Cys Glu Val 
465                 470                 475                 480


Val Met Met Ile Gly Leu Pro Gly Ala Gly Lys Thr Thr Trp Val Thr 
                485                 490                 495


Lys His Ala Ala Glu Asn Pro Gly Lys Tyr Asn Ile Leu Gly Thr Asn 
            500                 505                 510


Thr Ile Met Asp Lys Met Met Val Ala Gly Phe Lys Lys Gln Met Ala 
        515                 520                 525


Asp Thr Gly Lys Leu Asn Thr Leu Leu Gln Arg Ala Pro Gln Cys Leu 
    530                 535                 540


Gly Lys Phe Ile Glu Ile Ala Ala Arg Lys Lys Arg Asn Phe Ile Leu 
545                 550                 555                 560


Asp Gln Thr Asn Val Ser Ala Ala Ala Gln Arg Arg Lys Met Cys Leu 
                565                 570                 575


Phe Ala Gly Phe Gln Arg Lys Ala Val Val Val Cys Pro Lys Asp Glu 
            580                 585                 590


Asp Tyr Lys Gln Arg Thr Gln Lys Lys Ala Glu Val Glu Gly Lys Asp 
        595                 600                 605


Leu Pro Glu His Ala Val Leu Lys Met Lys Gly Asn Phe Thr Leu Pro 
    610                 615                 620


Glu Val Ala Glu Cys Phe Asp Glu Ile Thr Tyr Val Glu Leu Gln Lys 
625                 630                 635                 640


Glu Glu Ala Gln Lys Leu Leu Glu Gln Tyr Lys Glu Glu Ser Lys Lys 
                645                 650                 655


Ala Leu Pro Pro Glu Lys Lys Gln Asn Thr Gly Ser Lys Lys Ser Asn 
            660                 665                 670


Lys Asn Lys Ser Gly Lys Asn Gln Phe Asn Arg Gly Gly Gly His Arg 
        675                 680                 685


Gly Arg Gly Gly Phe Asn Met Arg Gly Gly Asn Phe Arg Gly Gly Gly 
    690                 695                 700


Asn Pro Trp Glu Ser Trp Arg Ile 
705                 710


<210>  2096
<211>  4149
<212>  DNA
<213>  Homo sapiens

<400>  2096
acgaagagct ggagaaacac ataagaaggc agatctaaga tggaagaaaa ggcggattcg     60

ggttgaaacg ccaagttgag gactgaagaa agcatttgga taaagcagcc tccaagctgg    120

gaaggagaaa agccaaacga gtatagccac caaagaccca gaaaggccaa tatatcatgc    180

agtgagtcgg ttgaactgaa aggcggtttc cttttcctcc atttgctcag tcccaattgg    240

aagcgcactg cgcggcctcc accgcgctct cggcccgggt tcggcgtggg ggcggggagg    300

taagtacggt aatgggcggg gccgagcgcg ggcgcgctcc ggctttcctc ctgcgcagtg    360

ctcccgtcag cgcagggggc ggggcgccta tattacgtgc gcggcgccgc tcctgcgaga    420

ggacgttgcg tgctcgctcg cgccaggcga gtctccgcgt ctccctcgcg aactcggtga    480

aaggaattgg cgccgttcga caccaggcgg atccgctctg cagcacgaac ccatctccag    540

ccgcagccgc agcccccctg ggaatcgtgg cggatataat aggaggggca acatgccaca    600

gagaggtggt ggcggtggag gaagtggtgg aatcggctat ccataccctc gtgcccctgt    660

ttttcctggc cgtggtagtt actcaaacag agggaactac aacagaggtg gaatgcccaa    720

cagagggaac tacaaccaga acttcagagg acgaggaaac aatcgtggct acaaaaatca    780

atctcagggc tacaaccagt ggcagcaggg tcaattctgg ggtcagaagc catggagtca    840

gcattatcac caaggatatt attgaatacc caaataaaac gaactgatac atatttctcc    900

aaaaccttca caagaagtcg actgttttct ttagtaggct aactttttaa acattccaca    960

agaggaagtg cctgcgggtt ccttttttag aagctttgtg ggttgatttt ttttcttttc   1020

ttttttgtac atttttaatt gcagtttaaa agtgaatcgt aagagaacct cagcattgtg   1080

cacgataaga gaatgtgtca gtatttcagg gttctacatt ttatctgtaa aatgtgactt   1140

tttttttttt ttatcacaac agaagtaaaa tgttgctttg tacctggtgt cttttattaa   1200

gaatttactc cccccatttc tcacagagaa taacagtcgg gagtcattgt cacaatataa   1260

tagaaatgtt agcaaccaga ttcatgtaag gactaagtgg tcctcatgaa ttgcattaag   1320

actctgtact gctcatatta cactccatcc tctctgtagt ttgctgggta gtggaggggg   1380

taagctaaat catagtttct gacaataact gggaaggttt tttcttaaaa taacaatgga   1440

attggtataa ttgggattga aaactaaaac ttggaactaa gatagagaag atggagtgta   1500

tgtagaaggg ctgttaaaaa tgtaaaactt ggttgcatta tttgtggagg ctcaaacttg   1560

tgaaggttaa taccataatt tttccatttg ttctgcattt tgattctgaa aagaaagctg   1620

gctttgccca tttcttatta aaaaaacttg ttgtaaatcc agttgtctaa tgggatctat   1680

atgaagttag ccatgtctgt atgcccttct cccacaaaat actgtataac tagtgtgctt   1740

gtagtagtta actccaccat ctttgtaagc taatgaaatt gtgagtcacc catttatatc   1800

ttaattttta atcatgtcag ttcttgaatg ggtatctcct tagcctgctg atttcttttt   1860

ctttctaaag aaagtgggtg gagaaattaa tttagacgtt tgtttgcaat aaaaagaatt   1920

cattttactc ttgttttggg attctcgcca tcaaggttca aaatcccttt atataactcc   1980

caagaggaga aatttattaa gtgtgtgctt tctggacagc ttattcttta ctctgcatag   2040

aacatttagg ttttaaaaac ttaaatgtat actgacaatt gatacataat tatgaagtaa   2100

agttgaattc ttcccttccc ctccccccca gacaactttt aacatattta atgaggggaa   2160

aaggtactgg ctgggagaag ttaacactga gtttatcatc tttacagaat gctaatgctg   2220

tcctcaactg attattttat atacatatat atgatacatg aaactctggg atcagatgct   2280

tttagaagcc atcatgcaag ccagtcattg atgtcactgc tacacaacac tgctaacttg   2340

actgtagcta tgtaataaca ttagatcccc taattgtaat tatattgggt ttgcacagaa   2400

cactttaatc ttcccctcac caatgtgaag tgaggaatca ggagtcaaac tgtagaacta   2460

aaatttgact tcagtctagc gtttccttgg tgtttttagg ttgctttggt aagtttaggt   2520

ttgctatatt tctgattgct tagaattttg ttttagccct ttaaaatcag atcataaata   2580

tgaattcata cttctaagga attttcttgc tataagctgg agtttaggtg atgtataggt   2640

tcagttgaga catttttgga acaggcaaat ccttagttaa cataagatat ttaacagttg   2700

aagatagtgt catggatttt tatctttttt agcaagtaat gctaagaacc actggcctga   2760

gctactactc ttcagtatac attattagga ttgcatagac ttactagagg aacagtttca   2820

ggttttgatg ctaatcagtg ttgtgtccta aagttgtcct ttgtgccttt aaaaagtttt   2880

ggatatatct tctagtttaa aattgcttat taaggaattc attttataat tgcagtggga   2940

aagtaatggt caagtaacac taggtagact atcatgcctg tttagcccag agaatttggg   3000

gggagagaga atagataaaa atggcaccca gaaaaatgtt aaaatcttta gtcaagacta   3060

gaattaatac aattgtctac acttgtatgg cagaaataac cttataaagt gtttaaggaa   3120

ttcagagaag ggaatgtacc aaataagcaa cagggagaaa attaggtaag aagtaagata   3180

cgaacgagaa acctgattta ttgctcatcc ttcccttgcc tccctaatgg caagcaaaac   3240

tctgaacatc tgaaaaggat gtagttctgg acaaatcctg actacccaga ggaaactcac   3300

tgtgagattg ctgttgattt gaagggtgct ttcactaagg ttatatttta aagtagaata   3360

acacatgctg agtgtaaact ggctttggat tggtcagctg cagtagtaca aaaacagcat   3420

agaatttgag aaaactaaaa ctgctatgag atagctatga gaaaactaaa actgctatga   3480

gatagaaatg atgtaaaatt atgtggaaag ttttccctca tatactcaca tacagccttt   3540

gaagggctct ggctctgacc ggttgatggc cttgagcgag atgaaatcat gaaattgagt   3600

caaatcaatt tgacattgaa atgacaagag gaaactctta aatacataaa aacaagctct   3660

catttgccta ggatagatac tgtcttaaaa ataaagactg aacctagatg ttctgagcac   3720

tagcaacaag gtattttaac aagtttaaag gaattctctg aaaaagttat aaaattattc   3780

taggaaacat aaccataata gtgttttaag ggactttcac ctggggattt tatattcatg   3840

aacagagtgt attctgtatt taaaatgtct catttgtggg aattggatga catgtttttt   3900

gataaattta ttcacaatat aaattgactt tttattctag gaccatgtga ataatgggtt   3960

ccattgcaca aatacaaata ttttaatagc ttcttaggca gtggtgtaga catcttggat   4020

ataaataatt gtagatcttg tatatttgat ttttaaaaaa ctagaataaa cagagaggca   4080

taaacatatc ttagagtcca agtggtagtg tttagcattg gatataataa atggatgttt   4140

tacaaagtg                                                           4149


<210>  2097
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  2097

Met Gly Gly Ala Glu Arg Gly Arg Ala Pro Ala Phe Leu Leu Arg Ser 
1               5                   10                  15


Ala Pro Val Ser Ala Gly Gly Gly Ala Pro Ile Leu Arg Ala Arg Arg 
            20                  25                  30


Arg Ser Cys Glu Arg Thr Leu Arg Ala Arg Ser Arg Gln Ala Ser Leu 
        35                  40                  45


Arg Val Ser Leu Ala Asn Ser Val Lys Gly Ile Gly Ala Val Arg His 
    50                  55                  60


Gln Ala Asp Pro Leu Cys Ser Thr Asn Pro Ser Pro Ala Ala Ala Ala 
65                  70                  75                  80


Ala Pro Leu Gly Ile Val Ala Asp Ile Ile Gly Gly Ala Thr Cys His 
                85                  90                  95


Arg Glu Val Val Ala Val Glu Glu Val Val Glu Ser Ala Ile His Thr 
            100                 105                 110


Leu Val Pro Leu Phe Phe Leu Ala Val Val Val Thr Gln Thr Glu Gly 
        115                 120                 125


Thr Thr Thr Glu Val Glu Cys Pro Thr Glu Gly Thr Thr Thr Arg Thr 
    130                 135                 140


Ser Glu Asp Glu Glu Thr Ile Val Ala Thr Lys Ile Asn Leu Arg Ala 
145                 150                 155                 160


Thr Thr Ser Gly Ser Arg Val Asn Ser Gly Val Arg Ser His Gly Val 
                165                 170                 175


Ser Ile Ile Thr Lys Asp Ile Ile Glu Tyr Pro Asn Lys Thr Asn 
            180                 185                 190


<210>  2098
<211>  6363
<212>  DNA
<213>  Homo sapiens

<400>  2098
acgaagagct ggagaaacac ataagaaggc agatctaaga tggaagaaaa ggcggattcg     60

ggttgaaacg ccaagttgag gactgaagaa agcatttgga taaagcagcc tccaagctgg    120

gaaggagaaa agccaaacga gtatagccac caaagaccca gaaaggccaa tatatcatgc    180

agtgagtcgg ttgaactgaa aggcggtttc cttttcctcc atttgctcag tcccaattgg    240

aagcgcactg cgcggcctcc accgcgctct cggcccgggt tcggcgtggg ggcggggagg    300

taagtacggt aatgggcggg gccgagcgcg ggcgcgctcc ggctttcctc ctgcgcagtg    360

ctcccgtcag cgcagggggc ggggcgccta tattacgtgc gcggcgccgc tcctgcgaga    420

ggacgttgcg tgctcgctcg cgccaggcga gtctccgcgt ctccctcgcg aactcggtga    480

aaggaattgg cgccgttcga caccaggcgg atccgctctg cagcacgaac ccatctccag    540

ccgcagccgc agccgccgcc cgggccgagg agcagccgca gcagccgcca ccagtggccg    600

agtgagcgga gccgagtttg aggcagcgcc tagcggtgaa tcggggccct caccatgagt    660

tcctcgcctg ttaatgtaaa aaagctgaag gtgtcggagc tgaaagagga gctcaagaag    720

cgacgccttt ctgacaaggg tctcaaggcc gagctcatgg agcgactcca ggctgcgctg    780

gacgacgagg aggccggggg ccgccccgcc atggagcccg ggaacggcag cctagacctg    840

ggcggggatt ccgctgggcg ctcgggagca ggcctcgagc aggaggccgc ggccggcggc    900

gatgaagagg aggaggaaga ggaagaggag gaggaaggaa tctccgctct ggacggcgac    960

cagatggagc taggagagga gaacggggcc gcgggggcgg ccgactcggg cccgatggag   1020

gaggaggagg ccgcctcgga agacgagaac ggcgacgatc agggtttcca ggaaggggaa   1080

gatgagctcg gggacgaaga ggaaggcgcg ggcgacgaga acgggcacgg ggagcagcag   1140

cctcaaccgc cggcgacgca gcagcaacag ccccaacagc agcgcggggc cgccaaggag   1200

gccgcgggga agagcagcgg ccccacctcg ctgttcgcgg tgacggtggc gccgcccggg   1260

gcgaggcagg gccagcagca ggcgggaggg gacggcaaaa cagaacagaa aggcggagat   1320

aaaaagaggg gtgttaaaag accacgagaa gatcatggcc gtggatattt tgagtacatt   1380

gaagagaaca agtatagcag agccaaatct cctcagccac ctgttgaaga agaagatgaa   1440

cacttcgatg acacagtggt ttgtcttgat acttataatt gtgatctaca ttttaaaata   1500

tcaagagatc gtctcagtgc ttcttccctt acaatggaga gttttgcttt tctttgggct   1560

ggaggaagag catcctatgg tgtgtcaaaa ggcaaagtgt gttttgagat gaaggttaca   1620

gagaagatcc cagtaaggca tttatataca aaagatattg acatacatga agttcgtatt   1680

ggctggtcac taactacaag tggaatgtta cttggtgaag aagaattttc ttatgggtat   1740

tctctaaaag gaataaaaac atgcaactgt gagactgaag attatggaga aaagtttgat   1800

gaaaatgatg tgattacatg ttttgctaac tttgaaagtg atgaagtaga actctcgtat   1860

gctaagaatg gacaagatct tggcgttgcc ttcaaaatca gtaaggaagt tcttgctgga   1920

cggccactgt tcccgcatgt tctctgccac aactgtgcag ttgaatttaa ttttggtcag   1980

aaggaaaagc catattttcc aatacctgaa gagtatactt tcatccagaa cgtcccctta   2040

gaggatcgag ttagaggacc aaaggggcct gaagagaaga aagattgtga agttgtgatg   2100

atgattggct tgccaggagc tggaaaaact acctgggtta ctaaacatgc agcagaaaat   2160

ccagggaaat ataacattct tggcacaaat actattatgg ataagatgat ggtggcaggt   2220

tttaagaagc aaatggcaga tactggaaaa ctgaacacac tgttgcagag agccccccag   2280

tgtcttggga aatttattga gattgctgcc cgaaagaagc gaaattttat tctggatcag   2340

acaaatgtgt ctgctgctgc ccagaggaga aaaatgtgcc tgtttgcagg cttccagcga   2400

aaagctgttg tagtttgccc aaaagatgaa gactataagc aaagaacaca gaagaaagca   2460

gaagtagagg ggaaagacct accagaacat gcggtcctca aaatgaaagg aaactttacc   2520

ctcccagagg tagctgagtg ctttgatgaa ataacctatg ttgaacttca gaaggaagaa   2580

gcccaaaaac tcttggagca atataaggaa gaaagcaaaa aggctcttcc accagaaaag   2640

aaacagaaca ctggctcaaa gaaaagcaat aaaaataaga gtggcaagaa ccagtttaac   2700

agaggtggtg gccatagagg acgtggagga ttcaatatgc gtggtggaaa tttcagagga   2760

ggaggcaacc cctgggaatc gtggcggata taataggagg ggcaacatgc cacagagagg   2820

tggtggcggt ggaggaagtg gtggaatcgg ctatccatac cctcgtgccc ctgtttttcc   2880

tggccgtggt agttactcaa acagagggaa ctacaacaga ggtggaatgc ccaacagagg   2940

gaactacaac cagaacttca gaggacgagg aaacaatcgt ggctacaaaa atcaatctca   3000

gggctacaac cagtggcagc agggtcaatt ctggggtcag aagccatgga gtcagcatta   3060

tcaccaagga tattattgaa tacccaaata aaacgaactg atacatattt ctccaaaacc   3120

ttcacaagaa gtcgactgtt ttctttagta ggctaacttt ttaaacattc cacaagagga   3180

agtgcctgcg ggttcctttt ttagaagctt tgtgggttga ttttttttct tttctttttt   3240

gtacattttt aattgcagtt taaaagtgaa tcgtaagaga acctcagcat tgtgcacgat   3300

aagagaatgt gtcagtattt cagggttcta cattttatct gtaaaatgtg actttttttt   3360

ttttttatca caacagaagt aaaatgttgc tttgtacctg gtgtctttta ttaagaattt   3420

actcccccca tttctcacag agaataacag tcgggagtca ttgtcacaat ataatagaaa   3480

tgttagcaac cagattcatg taaggactaa gtggtcctca tgaattgcat taagactctg   3540

tactgctcat attacactcc atcctctctg tagtttgctg ggtagtggag ggggtaagct   3600

aaatcatagt ttctgacaat aactgggaag gttttttctt aaaataacaa tggaattggt   3660

ataattggga ttgaaaacta aaacttggaa ctaagataga gaagatggag tgtatgtaga   3720

agggctgtta aaaatgtaaa acttggttgc attatttgtg gaggctcaaa cttgtgaagg   3780

ttaataccat aatttttcca tttgttctgc attttgattc tgaaaagaaa gctggctttg   3840

cccatttctt attaaaaaaa cttgttgtaa atccagttgt ctaatgggat ctatatgaag   3900

ttagccatgt ctgtatgccc ttctcccaca aaatactgta taactagtgt gcttgtagta   3960

gttaactcca ccatctttgt aagctaatga aattgtgagt cacccattta tatcttaatt   4020

tttaatcatg tcagttcttg aatgggtatc tccttagcct gctgatttct ttttctttct   4080

aaagaaagtg ggtggagaaa ttaatttaga cgtttgtttg caataaaaag aattcatttt   4140

actcttgttt tgggattctc gccatcaagg ttcaaaatcc ctttatataa ctcccaagag   4200

gagaaattta ttaagtgtgt gctttctgga cagcttattc tttactctgc atagaacatt   4260

taggttttaa aaacttaaat gtatactgac aattgataca taattatgaa gtaaagttga   4320

attcttccct tcccctcccc cccagacaac ttttaacata tttaatgagg ggaaaaggta   4380

ctggctggga gaagttaaca ctgagtttat catctttaca gaatgctaat gctgtcctca   4440

actgattatt ttatatacat atatatgata catgaaactc tgggatcaga tgcttttaga   4500

agccatcatg caagccagtc attgatgtca ctgctacaca acactgctaa cttgactgta   4560

gctatgtaat aacattagat cccctaattg taattatatt gggtttgcac agaacacttt   4620

aatcttcccc tcaccaatgt gaagtgagga atcaggagtc aaactgtaga actaaaattt   4680

gacttcagtc tagcgtttcc ttggtgtttt taggttgctt tggtaagttt aggtttgcta   4740

tatttctgat tgcttagaat tttgttttag ccctttaaaa tcagatcata aatatgaatt   4800

catacttcta aggaattttc ttgctataag ctggagttta ggtgatgtat aggttcagtt   4860

gagacatttt tggaacaggc aaatccttag ttaacataag atatttaaca gttgaagata   4920

gtgtcatgga tttttatctt ttttagcaag taatgctaag aaccactggc ctgagctact   4980

actcttcagt atacattatt aggattgcat agacttacta gaggaacagt ttcaggtttt   5040

gatgctaatc agtgttgtgt cctaaagttg tcctttgtgc ctttaaaaag ttttggatat   5100

atcttctagt ttaaaattgc ttattaagga attcatttta taattgcagt gggaaagtaa   5160

tggtcaagta acactaggta gactatcatg cctgtttagc ccagagaatt tggggggaga   5220

gagaatagat aaaaatggca cccagaaaaa tgttaaaatc tttagtcaag actagaatta   5280

atacaattgt ctacacttgt atggcagaaa taaccttata aagtgtttaa ggaattcaga   5340

gaagggaatg taccaaataa gcaacaggga gaaaattagg taagaagtaa gatacgaacg   5400

agaaacctga tttattgctc atccttccct tgcctcccta atggcaagca aaactctgaa   5460

catctgaaaa ggatgtagtt ctggacaaat cctgactacc cagaggaaac tcactgtgag   5520

attgctgttg atttgaaggg tgctttcact aaggttatat tttaaagtag aataacacat   5580

gctgagtgta aactggcttt ggattggtca gctgcagtag tacaaaaaca gcatagaatt   5640

tgagaaaact aaaactgcta tgagatagct atgagaaaac taaaactgct atgagataga   5700

aatgatgtaa aattatgtgg aaagttttcc ctcatatact cacatacagc ctttgaaggg   5760

ctctggctct gaccggttga tggccttgag cgagatgaaa tcatgaaatt gagtcaaatc   5820

aatttgacat tgaaatgaca agaggaaact cttaaataca taaaaacaag ctctcatttg   5880

cctaggatag atactgtctt aaaaataaag actgaaccta gatgttctga gcactagcaa   5940

caaggtattt taacaagttt aaaggaattc tctgaaaaag ttataaaatt attctaggaa   6000

acataaccat aatagtgttt taagggactt tcacctgggg attttatatt catgaacaga   6060

gtgtattctg tatttaaaat gtctcatttg tgggaattgg atgacatgtt ttttgataaa   6120

tttattcaca atataaattg actttttatt ctaggaccat gtgaataatg ggttccattg   6180

cacaaataca aatattttaa tagcttctta ggcagtggtg tagacatctt ggatataaat   6240

aattgtagat cttgtatatt tgatttttaa aaaactagaa taaacagaga ggcataaaca   6300

tatcttagag tccaagtggt agtgtttagc attggatata ataaatggat gttttacaaa   6360

gtg                                                                 6363


<210>  2099
<211>  712
<212>  PRT
<213>  Homo sapiens

<400>  2099

Met Ser Ser Ser Pro Val Asn Val Lys Lys Leu Lys Val Ser Glu Leu 
1               5                   10                  15


Lys Glu Glu Leu Lys Lys Arg Arg Leu Ser Asp Lys Gly Leu Lys Ala 
            20                  25                  30


Glu Leu Met Glu Arg Leu Gln Ala Ala Leu Asp Asp Glu Glu Ala Gly 
        35                  40                  45


Gly Arg Pro Ala Met Glu Pro Gly Asn Gly Ser Leu Asp Leu Gly Gly 
    50                  55                  60


Asp Ser Ala Gly Arg Ser Gly Ala Gly Leu Glu Gln Glu Ala Ala Ala 
65                  70                  75                  80


Gly Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ile 
                85                  90                  95


Ser Ala Leu Asp Gly Asp Gln Met Glu Leu Gly Glu Glu Asn Gly Ala 
            100                 105                 110


Ala Gly Ala Ala Asp Ser Gly Pro Met Glu Glu Glu Glu Ala Ala Ser 
        115                 120                 125


Glu Asp Glu Asn Gly Asp Asp Gln Gly Phe Gln Glu Gly Glu Asp Glu 
    130                 135                 140


Leu Gly Asp Glu Glu Glu Gly Ala Gly Asp Glu Asn Gly His Gly Glu 
145                 150                 155                 160


Gln Gln Pro Gln Pro Pro Ala Thr Gln Gln Gln Gln Pro Gln Gln Gln 
                165                 170                 175


Arg Gly Ala Ala Lys Glu Ala Ala Gly Lys Ser Ser Gly Pro Thr Ser 
            180                 185                 190


Leu Phe Ala Val Thr Val Ala Pro Pro Gly Ala Arg Gln Gly Gln Gln 
        195                 200                 205


Gln Ala Gly Gly Asp Gly Lys Thr Glu Gln Lys Gly Gly Asp Lys Lys 
    210                 215                 220


Arg Gly Val Lys Arg Pro Arg Glu Asp His Gly Arg Gly Tyr Phe Glu 
225                 230                 235                 240


Tyr Ile Glu Glu Asn Lys Tyr Ser Arg Ala Lys Ser Pro Gln Pro Pro 
                245                 250                 255


Val Glu Glu Glu Asp Glu His Phe Asp Asp Thr Val Val Cys Leu Asp 
            260                 265                 270


Thr Tyr Asn Cys Asp Leu His Phe Lys Ile Ser Arg Asp Arg Leu Ser 
        275                 280                 285


Ala Ser Ser Leu Thr Met Glu Ser Phe Ala Phe Leu Trp Ala Gly Gly 
    290                 295                 300


Arg Ala Ser Tyr Gly Val Ser Lys Gly Lys Val Cys Phe Glu Met Lys 
305                 310                 315                 320


Val Thr Glu Lys Ile Pro Val Arg His Leu Tyr Thr Lys Asp Ile Asp 
                325                 330                 335


Ile His Glu Val Arg Ile Gly Trp Ser Leu Thr Thr Ser Gly Met Leu 
            340                 345                 350


Leu Gly Glu Glu Glu Phe Ser Tyr Gly Tyr Ser Leu Lys Gly Ile Lys 
        355                 360                 365


Thr Cys Asn Cys Glu Thr Glu Asp Tyr Gly Glu Lys Phe Asp Glu Asn 
    370                 375                 380


Asp Val Ile Thr Cys Phe Ala Asn Phe Glu Ser Asp Glu Val Glu Leu 
385                 390                 395                 400


Ser Tyr Ala Lys Asn Gly Gln Asp Leu Gly Val Ala Phe Lys Ile Ser 
                405                 410                 415


Lys Glu Val Leu Ala Gly Arg Pro Leu Phe Pro His Val Leu Cys His 
            420                 425                 430


Asn Cys Ala Val Glu Phe Asn Phe Gly Gln Lys Glu Lys Pro Tyr Phe 
        435                 440                 445


Pro Ile Pro Glu Glu Tyr Thr Phe Ile Gln Asn Val Pro Leu Glu Asp 
    450                 455                 460


Arg Val Arg Gly Pro Lys Gly Pro Glu Glu Lys Lys Asp Cys Glu Val 
465                 470                 475                 480


Val Met Met Ile Gly Leu Pro Gly Ala Gly Lys Thr Thr Trp Val Thr 
                485                 490                 495


Lys His Ala Ala Glu Asn Pro Gly Lys Tyr Asn Ile Leu Gly Thr Asn 
            500                 505                 510


Thr Ile Met Asp Lys Met Met Val Ala Gly Phe Lys Lys Gln Met Ala 
        515                 520                 525


Asp Thr Gly Lys Leu Asn Thr Leu Leu Gln Arg Ala Pro Gln Cys Leu 
    530                 535                 540


Gly Lys Phe Ile Glu Ile Ala Ala Arg Lys Lys Arg Asn Phe Ile Leu 
545                 550                 555                 560


Asp Gln Thr Asn Val Ser Ala Ala Ala Gln Arg Arg Lys Met Cys Leu 
                565                 570                 575


Phe Ala Gly Phe Gln Arg Lys Ala Val Val Val Cys Pro Lys Asp Glu 
            580                 585                 590


Asp Tyr Lys Gln Arg Thr Gln Lys Lys Ala Glu Val Glu Gly Lys Asp 
        595                 600                 605


Leu Pro Glu His Ala Val Leu Lys Met Lys Gly Asn Phe Thr Leu Pro 
    610                 615                 620


Glu Val Ala Glu Cys Phe Asp Glu Ile Thr Tyr Val Glu Leu Gln Lys 
625                 630                 635                 640


Glu Glu Ala Gln Lys Leu Leu Glu Gln Tyr Lys Glu Glu Ser Lys Lys 
                645                 650                 655


Ala Leu Pro Pro Glu Lys Lys Gln Asn Thr Gly Ser Lys Lys Ser Asn 
            660                 665                 670


Lys Asn Lys Ser Gly Lys Asn Gln Phe Asn Arg Gly Gly Gly His Arg 
        675                 680                 685


Gly Arg Gly Gly Phe Asn Met Arg Gly Gly Asn Phe Arg Gly Gly Gly 
    690                 695                 700


Asn Pro Trp Glu Ser Trp Arg Ile 
705                 710


<210>  2100
<211>  6194
<212>  DNA
<213>  Homo sapiens

<400>  2100
acgaagagct ggagaaacac ataagaaggc agatctaaga tggaagaaaa ggcggattcg     60

ggttgaaacg ccaagttgag gactgaagaa agcatttgga taaagcagcc tccaagctgg    120

gaaggagaaa agccaaacga gtatagccac caaagaccca gaaaggccaa tatatcatgc    180

agtgagtcgg ttgaactgaa aggcggtttc cttttcctcc atttgctcag tcccaattgg    240

aagcgcactg cgcggcctcc accgcgctct cggcccgggt tcggcgtggg ggcggggagg    300

taagtacggt aatgggcggg gccgagcgcg ggcgcgctcc ggctttcctc ctgcgcagtg    360

ctcccgtcag cgcagggggc ggggcgccta tattacgtgc gcggcgccgc tcctgcgaga    420

ggacgttgcg tgctcgctcg cgccaggcga gtctccgcgt ctccctcgcg aactcggtga    480

aaggaattgg cgccgttcga caccaggcgg atccgctctg cagcacgaac ccatctccag    540

ccgcagccgc agccgccgcc cgggccgagg agcagccgca gcagccgcca ccagtggccg    600

agtgagcgga gccgagtttg aggcagcgcc tagcggtgaa tcggggccct caccatgagt    660

tcctcgcctg ttaatgtaaa aaagctgaag gtgtcggagc tgaaagagga gctcaagaag    720

cgacgccttt ctgacaaggg tctcaaggcc gagctcatgg agcgactcca ggctgcgctg    780

gacgacgagg aggccggggg ccgccccgcc atggagcccg gaacggcgac gatcagggtt    840

tccaggaagg ggaagatgag ctcggggacg aagaggaagg cgcgggcgac gagaacgggc    900

acggggagca gcagcctcaa ccgccggcga cgcagcagca acagccccaa cagcagcgcg    960

gggccgccaa ggaggccgcg gggaagagca gcggccccac ctcgctgttc gcggtgacgg   1020

tggcgccgcc cggggcgagg cagggccagc agcaggcggg aggtaagaag aaggcggaag   1080

gcggcggagg cggcggtcgc cccggggctc cggcggcggg ggacggcaaa acagaacaga   1140

aaggcggaga taaaaagagg ggtgttaaaa gaccacgaga agatcatggc cgtggatatt   1200

ttgagtacat tgaagagaac aagtatagca gagccaaatc tcctcagcca cctgttgaag   1260

aagaagatga acacttcgat gacacagtgg tttgtcttga tacttataat tgtgatctac   1320

attttaaaat atcaagagat cgtctcagtg cttcttccct tacaatggag agttttgctt   1380

ttctttgggc tggaggaaga gcatcctatg gtgtgtcaaa aggcaaagtg tgttttgaga   1440

tgaaggttac agagaagatc ccagtaaggc atttatatac aaaagatatt gacatacatg   1500

aagttcgtat tggctggtca ctaactacaa gtggaatgtt acttggtgaa gaagaatttt   1560

cttatgggta ttctctaaaa ggaataaaaa catgcaactg tgagactgaa gattatggag   1620

aaaagtttga tgaaaatgat gtgattacat gttttgctaa ctttgaaagt gatgaagtag   1680

aactctcgta tgctaagaat ggacaagatc ttggcgttgc cttcaaaatc agtaaggaag   1740

ttcttgctgg acggccactg ttcccgcatg ttctctgcca caactgtgca gttgaattta   1800

attttggtca gaaggaaaag ccatattttc caatacctga agagtatact ttcatccaga   1860

acgtcccctt agaggatcga gttagaggac caaaggggcc tgaagagaag aaagattgtg   1920

aagttgtgat gatgattggc ttgccaggag ctggaaaaac tacctgggtt actaaacatg   1980

cagcagaaaa tccagggaaa tataacattc ttggcacaaa tactattatg gataagatga   2040

tggtggcagg ttttaagaag caaatggcag atactggaaa actgaacaca ctgttgcaga   2100

gagcccccca gtgtcttggg aaatttattg agattgctgc ccgaaagaag cgaaatttta   2160

ttctggatca gacaaatgtg tctgctgctg cccagaggag aaaaatgtgc ctgtttgcag   2220

gcttccagcg aaaagctgtt gtagtttgcc caaaagatga agactataag caaagaacac   2280

agaagaaagc agaagtagag gggaaagacc taccagaaca tgcggtcctc aaaatgaaag   2340

gaaactttac cctcccagag gtagctgagt gctttgatga aataacctat gttgaacttc   2400

agaaggaaga agcccaaaaa ctcttggagc aatataagga agaaagcaaa aaggctcttc   2460

caccagaaaa gaaacagaac actggctcaa agaaaagcaa taaaaataag agtggcaaga   2520

accagtttaa cagaggtggt ggccatagag gacgtggagg attcaatatg cgtggtggaa   2580

atttcagagg aggaggcaac ccctgggaat cgtggcggat ataataggag gggcaacatg   2640

ccacagagag gtggtggcgg tggaggaagt ggtggaatcg gctatccata ccctcgtgcc   2700

cctgtttttc ctggccgtgg tagttactca aacagaggga actacaacag aggtggaatg   2760

cccaacagag ggaactacaa ccagaacttc agaggacgag gaaacaatcg tggctacaaa   2820

aatcaatctc agggctacaa ccagtggcag cagggtcaat tctggggtca gaagccatgg   2880

agtcagcatt atcaccaagg atattattga atacccaaat aaaacgaact gatacatatt   2940

tctccaaaac cttcacaaga agtcgactgt tttctttagt aggctaactt tttaaacatt   3000

ccacaagagg aagtgcctgc gggttccttt tttagaagct ttgtgggttg attttttttc   3060

ttttcttttt tgtacatttt taattgcagt ttaaaagtga atcgtaagag aacctcagca   3120

ttgtgcacga taagagaatg tgtcagtatt tcagggttct acattttatc tgtaaaatgt   3180

gacttttttt tttttttatc acaacagaag taaaatgttg ctttgtacct ggtgtctttt   3240

attaagaatt tactcccccc atttctcaca gagaataaca gtcgggagtc attgtcacaa   3300

tataatagaa atgttagcaa ccagattcat gtaaggacta agtggtcctc atgaattgca   3360

ttaagactct gtactgctca tattacactc catcctctct gtagtttgct gggtagtgga   3420

gggggtaagc taaatcatag tttctgacaa taactgggaa ggttttttct taaaataaca   3480

atggaattgg tataattggg attgaaaact aaaacttgga actaagatag agaagatgga   3540

gtgtatgtag aagggctgtt aaaaatgtaa aacttggttg cattatttgt ggaggctcaa   3600

acttgtgaag gttaatacca taatttttcc atttgttctg cattttgatt ctgaaaagaa   3660

agctggcttt gcccatttct tattaaaaaa acttgttgta aatccagttg tctaatggga   3720

tctatatgaa gttagccatg tctgtatgcc cttctcccac aaaatactgt ataactagtg   3780

tgcttgtagt agttaactcc accatctttg taagctaatg aaattgtgag tcacccattt   3840

atatcttaat ttttaatcat gtcagttctt gaatgggtat ctccttagcc tgctgatttc   3900

tttttctttc taaagaaagt gggtggagaa attaatttag acgtttgttt gcaataaaaa   3960

gaattcattt tactcttgtt ttgggattct cgccatcaag gttcaaaatc cctttatata   4020

actcccaaga ggagaaattt attaagtgtg tgctttctgg acagcttatt ctttactctg   4080

catagaacat ttaggtttta aaaacttaaa tgtatactga caattgatac ataattatga   4140

agtaaagttg aattcttccc ttcccctccc ccccagacaa cttttaacat atttaatgag   4200

gggaaaaggt actggctggg agaagttaac actgagttta tcatctttac agaatgctaa   4260

tgctgtcctc aactgattat tttatataca tatatatgat acatgaaact ctgggatcag   4320

atgcttttag aagccatcat gcaagccagt cattgatgtc actgctacac aacactgcta   4380

acttgactgt agctatgtaa taacattaga tcccctaatt gtaattatat tgggtttgca   4440

cagaacactt taatcttccc ctcaccaatg tgaagtgagg aatcaggagt caaactgtag   4500

aactaaaatt tgacttcagt ctagcgtttc cttggtgttt ttaggttgct ttggtaagtt   4560

taggtttgct atatttctga ttgcttagaa ttttgtttta gccctttaaa atcagatcat   4620

aaatatgaat tcatacttct aaggaatttt cttgctataa gctggagttt aggtgatgta   4680

taggttcagt tgagacattt ttggaacagg caaatcctta gttaacataa gatatttaac   4740

agttgaagat agtgtcatgg atttttatct tttttagcaa gtaatgctaa gaaccactgg   4800

cctgagctac tactcttcag tatacattat taggattgca tagacttact agaggaacag   4860

tttcaggttt tgatgctaat cagtgttgtg tcctaaagtt gtcctttgtg cctttaaaaa   4920

gttttggata tatcttctag tttaaaattg cttattaagg aattcatttt ataattgcag   4980

tgggaaagta atggtcaagt aacactaggt agactatcat gcctgtttag cccagagaat   5040

ttggggggag agagaataga taaaaatggc acccagaaaa atgttaaaat ctttagtcaa   5100

gactagaatt aatacaattg tctacacttg tatggcagaa ataaccttat aaagtgttta   5160

aggaattcag agaagggaat gtaccaaata agcaacaggg agaaaattag gtaagaagta   5220

agatacgaac gagaaacctg atttattgct catccttccc ttgcctccct aatggcaagc   5280

aaaactctga acatctgaaa aggatgtagt tctggacaaa tcctgactac ccagaggaaa   5340

ctcactgtga gattgctgtt gatttgaagg gtgctttcac taaggttata ttttaaagta   5400

gaataacaca tgctgagtgt aaactggctt tggattggtc agctgcagta gtacaaaaac   5460

agcatagaat ttgagaaaac taaaactgct atgagatagc tatgagaaaa ctaaaactgc   5520

tatgagatag aaatgatgta aaattatgtg gaaagttttc cctcatatac tcacatacag   5580

cctttgaagg gctctggctc tgaccggttg atggccttga gcgagatgaa atcatgaaat   5640

tgagtcaaat caatttgaca ttgaaatgac aagaggaaac tcttaaatac ataaaaacaa   5700

gctctcattt gcctaggata gatactgtct taaaaataaa gactgaacct agatgttctg   5760

agcactagca acaaggtatt ttaacaagtt taaaggaatt ctctgaaaaa gttataaaat   5820

tattctagga aacataacca taatagtgtt ttaagggact ttcacctggg gattttatat   5880

tcatgaacag agtgtattct gtatttaaaa tgtctcattt gtgggaattg gatgacatgt   5940

tttttgataa atttattcac aatataaatt gactttttat tctaggacca tgtgaataat   6000

gggttccatt gcacaaatac aaatatttta atagcttctt aggcagtggt gtagacatct   6060

tggatataaa taattgtaga tcttgtatat ttgattttta aaaaactaga ataaacagag   6120

aggcataaac atatcttaga gtccaagtgg tagtgtttag cattggatat aataaatgga   6180

tgttttacaa agtg                                                     6194


<210>  2101
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  2101

Met Glu Ser Phe Ala Phe Leu Trp Ala Gly Gly Arg Ala Ser Tyr Gly 
1               5                   10                  15


Val Ser Lys Gly Lys Val Cys Phe Glu Met Lys Val Thr Glu Lys Ile 
            20                  25                  30


Pro Val Arg His Leu Tyr Thr Lys Asp Ile Asp Ile His Glu Val Arg 
        35                  40                  45


Ile Gly Trp Ser Leu Thr Thr Ser Gly Met Leu Leu Gly Glu Glu Glu 
    50                  55                  60


Phe Ser Tyr Gly Tyr Ser Leu Lys Gly Ile Lys Thr Cys Asn Cys Glu 
65                  70                  75                  80


Thr Glu Asp Tyr Gly Glu Lys Phe Asp Glu Asn Asp Val Ile Thr Cys 
                85                  90                  95


Phe Ala Asn Phe Glu Ser Asp Glu Val Glu Leu Ser Tyr Ala Lys Asn 
            100                 105                 110


Gly Gln Asp Leu Gly Val Ala Phe Lys Ile Ser Lys Glu Val Leu Ala 
        115                 120                 125


Gly Arg Pro Leu Phe Pro His Val Leu Cys His Asn Cys Ala Val Glu 
    130                 135                 140


Phe Asn Phe Gly Gln Lys Glu Lys Pro Tyr Phe Pro Ile Pro Glu Glu 
145                 150                 155                 160


Tyr Thr Phe Ile Gln Asn Val Pro Leu Glu Asp Arg Val Arg Gly Pro 
                165                 170                 175


Lys Gly Pro Glu Glu Lys Lys Asp Cys Glu Val Val Met Met Ile Gly 
            180                 185                 190


Leu Pro Gly Ala Gly Lys Thr Thr Trp Val Thr Lys His Ala Ala Glu 
        195                 200                 205


Asn Pro Gly Lys Tyr Asn Ile Leu Gly Thr Asn Thr Ile Met Asp Lys 
    210                 215                 220


Met Met Val Ala Gly Phe Lys Lys Gln Met Ala Asp Thr Gly Lys Leu 
225                 230                 235                 240


Asn Thr Leu Leu Gln Arg Ala Pro Gln Cys Leu Gly Lys Phe Ile Glu 
                245                 250                 255


Ile Ala Ala Arg Lys Lys Arg Asn Phe Ile Leu Asp Gln Thr Asn Val 
            260                 265                 270


Ser Ala Ala Ala Gln Arg Arg Lys Met Cys Leu Phe Ala Gly Phe Gln 
        275                 280                 285


Arg Lys Ala Val Val Val Cys Pro Lys Asp Glu Asp Tyr Lys Gln Arg 
    290                 295                 300


Thr Gln Lys Lys Ala Glu Val Glu Gly Lys Asp Leu Pro Glu His Ala 
305                 310                 315                 320


Val Leu Lys Met Lys Gly Asn Phe Thr Leu Pro Glu Val Ala Glu Cys 
                325                 330                 335


Phe Asp Glu Ile Thr Tyr Val Glu Leu Gln Lys Glu Glu Ala Gln Lys 
            340                 345                 350


Leu Leu Glu Gln Tyr Lys Glu Glu Ser Lys Lys Ala Leu Pro Pro Glu 
        355                 360                 365


Lys Lys Gln Asn Thr Gly Ser Lys Lys Ser Asn Lys Asn Lys Ser Gly 
    370                 375                 380


Lys Asn Gln Phe Asn Arg Gly Gly Gly His Arg Gly Arg Gly Gly Phe 
385                 390                 395                 400


Asn Met Arg Gly Gly Asn Phe Arg Gly Gly Gly Asn Pro Trp Glu Ser 
                405                 410                 415


Trp Arg Ile 



<210>  2102
<211>  4146
<212>  DNA
<213>  Homo sapiens

<400>  2102
acgaagagct ggagaaacac ataagaaggc agatctaaga tggaagaaaa ggcggattcg     60

ggttgaaacg ccaagttgag gactgaagaa agcatttgga taaagcagcc tccaagctgg    120

gaaggagaaa agccaaacga gtatagccac caaagaccca gaaaggccaa tatatcatgc    180

agtgagtcgg ttgaactgaa aggcggtttc cttttcctcc atttgctcag tcccaattgg    240

aagcgcactg cgcggcctcc accgcgctct cggcccgggt tcggcgtggg ggcggggagg    300

taagtacggt aatgggcggg gccgagcgcg ggcgcgctcc ggctttcctc ctgcgcagtg    360

ctcccgtcag cgcagggggc ggggcgccta tattacgtgc gcggcgccgc tcctgcgaga    420

ggacgttgcg tgctcgctcg cgccaggcga gtctccgcgt ctccctcgcg aactcggtga    480

aaggaattgg cgccgttcga caccaggcgg atccgctctg cagcacgaac ccatctccag    540

ccgcagccgc agccgccgcc cgggccgagg agcagccgca gcagccgcca ccagtggccg    600

agtgagcgga gccgagtttg aggcagcgcc tagcggtgaa tcggggccct caccatgagt    660

tcctcgcctg ttaatgtaaa aaagctgaag gtgtcggagc tgaaagagga gctcaagaag    720

cgacgccttt ctgacaaggg tctcaaggcc gagctcatgg agcgactcca ggctgcgctg    780

gacgacgagg aggccggggg ccgccccgcc atggagcccg ggaacggcag cctagacctg    840

ggcggggatt ccgctgggcg ctcgggagca ggcctcgagc aggaggccgc ggccggcggc    900

gatgaagagg aggaggaaga ggaagaggag gaggaaggaa tctccgctct ggacggcgac    960

cagatggagc taggagagga gaacggggcc gcgggggcgg ccgactcggg cccgatggag   1020

gaggaggagg ccgcctcgga agacgagaac ggcgacgatc agggtttcca ggaaggggaa   1080

gatgagctcg gggacgaaga ggaaggcgcg ggcgacgaga acgggcacgg ggagcagcag   1140

cctcaaccgc cggcgacgca gcagcaacag ccccaacagc agcgcggggc cgccaaggag   1200

gccgcgggga agagcagcgg ccccacctcg ctgttcgcgg tgacggtggc gccgcccggg   1260

gcgaggcagg gccagcagca ggcgggaggg gacggcaaaa cagaacagaa aggcggagat   1320

aaaaagaggg gtgttaaaag accacgagaa gatcatggcc gtggatattt tgagtacatt   1380

gaagagaaca agtatagcag agccaaatct cctcagccac ctgttgaaga agaagatgaa   1440

cacttcgatg acacagtggt ttgtcttgat acttataatt gtgatctaca ttttaaaata   1500

tcaagagatc gtctcagtgc ttcttccctt acaatggaga gttttgcttt tctttgggct   1560

ggaggaagag catcctatgg tgtgtcaaaa ggcaaagtgt gttttgagat gaaggttaca   1620

gagaagatcc cagtaaggca tttatataca aaagatattg acatacatga agttcgtatt   1680

ggctggtcac taactacaag tggaatgtta cttggtgaag aagaattttc ttatgggtat   1740

tctctaaaag gaataaaaac atgcaactgt gagactgaag attatggaga aaagtttgat   1800

gaaaatgatg tgattacatg ttttgctaac tttgaaagtg atgaagtaga actctcgtat   1860

gctaagaatg gacaagatct tggcgttgcc ttcaaaatca gtaaggaagt tcttgctgga   1920

cggccactgt tcccgcatgt tctctgccac aactgtgcag ttgaatttaa ttttggtcag   1980

aaggaaaagc catattttcc aatacctgaa gagtatactt tcatccagaa cgtcccctta   2040

gaggatcgag ttagaggacc aaaggggcct gaagagaaga aagattgtga agttgtgatg   2100

atgattggct tgccaggagc tggaaaaact acctgggtta ctaaacatgc agcagaaaat   2160

ccagggaaat ataacattct tggcacaaat actattatgg ataagatgat ggtggcaggt   2220

tttaagaagc aaatggcaga tactggaaaa ctgaacacac tgttgcagag agccccccag   2280

tgtcttggga aatttattga gattgctgcc cgaaagaagc gaaattttat tctggatcag   2340

acaaatgtgt ctgctgctgc ccagaggaga aaaatgtgcc tgtttgcagg cttccagcga   2400

aaagctgttg tagtttgccc aaaagatgaa gactataagc aaagaacaca gaagaaagca   2460

gaagtagagg ggaaagacct accagaacat gcggtcctca aaatgaaagg aaactttacc   2520

ctcccagagg tagctgagtg ctttgatgaa ataacctatg ttgaacttca gaaggaagaa   2580

gcccaaaaac tcttggagca atataaggaa gaaagcaaaa aggctcttcc accagaaaag   2640

aaacagaaca ctggctcaaa gaaaagcaat aaaaataaga gtggcaagaa ccagtttaac   2700

agaggtggtg gccatagagg acgtggagga ttcaatatgc gtggtggaaa tttcagagga   2760

ggaggcaacc cctgggaatc gtggcggata taataggagg ggcaacatgc cacagagagg   2820

tggtggcggt ggaggaagtg gtggaatcgg ctatccatac cctcgtgccc ctgtttttcc   2880

tggccgtggt agttactcaa acagagggaa ctacaacaga ggtggaatgc ccaacagagg   2940

gaactacaac cagaacttca gaggacgagg aaacaatcgt ggctacaaaa atcaatctca   3000

gggctacaac cagtggcagc agggtcaatt ctggggtcag aagccatgga gtcagcatta   3060

tcaccaagga tattattgaa tacccaaata aaacgaactg atacatattt ctccaaaacc   3120

ttcacaagaa gtcgactgtt ttctttagta ggctaacttt ttaaacattc cacaagagga   3180

agtgcctgcg ggttcctttt ttagaagctt tgtgggttga ttttttttct tttctttttt   3240

gtacattttt aattgcagtt taaaagtgaa tcgtaagaga acctcagcat tgtgcacgat   3300

aagagaatgt gtcagtattt cagggttcta cattttatct gtaaaatgtg actttttttt   3360

ttttttatca caacagaagt aaaatgttgc tttgtacctg gtgtctttta ttaagaattt   3420

actcccccca tttctcacag agaataacag tcgggagtca ttgtcacaat ataatagaaa   3480

tgttagcaac cagattcatg taaggactaa gtggtcctca tgaattgcat taagactctg   3540

tactgctcat attacactcc atcctctctg tagtttgctg ggtagtggag ggggtaagct   3600

aaatcatagt ttctgacaat aactgggaag gttttttctt aaaataacaa tggaattggt   3660

ataattggga ttgaaaacta aaacttggaa ctaagataga gaagatggag tgtatgtaga   3720

agggctgtta aaaatgtaaa acttggttgc attatttgtg gaggctcaaa cttgtgaagg   3780

ttaataccat aatttttcca tttgttctgc attttgattc tgaaaagaaa gctggctttg   3840

cccatttctt attaaaaaaa cttgttgtaa atccagttgt ctaatgggat ctatatgaag   3900

ttagccatgt ctgtatgccc ttctcccaca aaatactgta taactagtgt gcttgtagta   3960

gttaactcca ccatctttgt aagctaatga aattgtgagt cacccattta tatcttaatt   4020

tttaatcatg tcagttcttg aatgggtatc tccttagcct gctgatttct ttttctttct   4080

aaagaaagtg ggtggagaaa ttaatttaga cgtttgtttg caataaaaag aattcatttt   4140

actctt                                                              4146


<210>  2103
<211>  712
<212>  PRT
<213>  Homo sapiens

<400>  2103

Met Ser Ser Ser Pro Val Asn Val Lys Lys Leu Lys Val Ser Glu Leu 
1               5                   10                  15


Lys Glu Glu Leu Lys Lys Arg Arg Leu Ser Asp Lys Gly Leu Lys Ala 
            20                  25                  30


Glu Leu Met Glu Arg Leu Gln Ala Ala Leu Asp Asp Glu Glu Ala Gly 
        35                  40                  45


Gly Arg Pro Ala Met Glu Pro Gly Asn Gly Ser Leu Asp Leu Gly Gly 
    50                  55                  60


Asp Ser Ala Gly Arg Ser Gly Ala Gly Leu Glu Gln Glu Ala Ala Ala 
65                  70                  75                  80


Gly Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ile 
                85                  90                  95


Ser Ala Leu Asp Gly Asp Gln Met Glu Leu Gly Glu Glu Asn Gly Ala 
            100                 105                 110


Ala Gly Ala Ala Asp Ser Gly Pro Met Glu Glu Glu Glu Ala Ala Ser 
        115                 120                 125


Glu Asp Glu Asn Gly Asp Asp Gln Gly Phe Gln Glu Gly Glu Asp Glu 
    130                 135                 140


Leu Gly Asp Glu Glu Glu Gly Ala Gly Asp Glu Asn Gly His Gly Glu 
145                 150                 155                 160


Gln Gln Pro Gln Pro Pro Ala Thr Gln Gln Gln Gln Pro Gln Gln Gln 
                165                 170                 175


Arg Gly Ala Ala Lys Glu Ala Ala Gly Lys Ser Ser Gly Pro Thr Ser 
            180                 185                 190


Leu Phe Ala Val Thr Val Ala Pro Pro Gly Ala Arg Gln Gly Gln Gln 
        195                 200                 205


Gln Ala Gly Gly Asp Gly Lys Thr Glu Gln Lys Gly Gly Asp Lys Lys 
    210                 215                 220


Arg Gly Val Lys Arg Pro Arg Glu Asp His Gly Arg Gly Tyr Phe Glu 
225                 230                 235                 240


Tyr Ile Glu Glu Asn Lys Tyr Ser Arg Ala Lys Ser Pro Gln Pro Pro 
                245                 250                 255


Val Glu Glu Glu Asp Glu His Phe Asp Asp Thr Val Val Cys Leu Asp 
            260                 265                 270


Thr Tyr Asn Cys Asp Leu His Phe Lys Ile Ser Arg Asp Arg Leu Ser 
        275                 280                 285


Ala Ser Ser Leu Thr Met Glu Ser Phe Ala Phe Leu Trp Ala Gly Gly 
    290                 295                 300


Arg Ala Ser Tyr Gly Val Ser Lys Gly Lys Val Cys Phe Glu Met Lys 
305                 310                 315                 320


Val Thr Glu Lys Ile Pro Val Arg His Leu Tyr Thr Lys Asp Ile Asp 
                325                 330                 335


Ile His Glu Val Arg Ile Gly Trp Ser Leu Thr Thr Ser Gly Met Leu 
            340                 345                 350


Leu Gly Glu Glu Glu Phe Ser Tyr Gly Tyr Ser Leu Lys Gly Ile Lys 
        355                 360                 365


Thr Cys Asn Cys Glu Thr Glu Asp Tyr Gly Glu Lys Phe Asp Glu Asn 
    370                 375                 380


Asp Val Ile Thr Cys Phe Ala Asn Phe Glu Ser Asp Glu Val Glu Leu 
385                 390                 395                 400


Ser Tyr Ala Lys Asn Gly Gln Asp Leu Gly Val Ala Phe Lys Ile Ser 
                405                 410                 415


Lys Glu Val Leu Ala Gly Arg Pro Leu Phe Pro His Val Leu Cys His 
            420                 425                 430


Asn Cys Ala Val Glu Phe Asn Phe Gly Gln Lys Glu Lys Pro Tyr Phe 
        435                 440                 445


Pro Ile Pro Glu Glu Tyr Thr Phe Ile Gln Asn Val Pro Leu Glu Asp 
    450                 455                 460


Arg Val Arg Gly Pro Lys Gly Pro Glu Glu Lys Lys Asp Cys Glu Val 
465                 470                 475                 480


Val Met Met Ile Gly Leu Pro Gly Ala Gly Lys Thr Thr Trp Val Thr 
                485                 490                 495


Lys His Ala Ala Glu Asn Pro Gly Lys Tyr Asn Ile Leu Gly Thr Asn 
            500                 505                 510


Thr Ile Met Asp Lys Met Met Val Ala Gly Phe Lys Lys Gln Met Ala 
        515                 520                 525


Asp Thr Gly Lys Leu Asn Thr Leu Leu Gln Arg Ala Pro Gln Cys Leu 
    530                 535                 540


Gly Lys Phe Ile Glu Ile Ala Ala Arg Lys Lys Arg Asn Phe Ile Leu 
545                 550                 555                 560


Asp Gln Thr Asn Val Ser Ala Ala Ala Gln Arg Arg Lys Met Cys Leu 
                565                 570                 575


Phe Ala Gly Phe Gln Arg Lys Ala Val Val Val Cys Pro Lys Asp Glu 
            580                 585                 590


Asp Tyr Lys Gln Arg Thr Gln Lys Lys Ala Glu Val Glu Gly Lys Asp 
        595                 600                 605


Leu Pro Glu His Ala Val Leu Lys Met Lys Gly Asn Phe Thr Leu Pro 
    610                 615                 620


Glu Val Ala Glu Cys Phe Asp Glu Ile Thr Tyr Val Glu Leu Gln Lys 
625                 630                 635                 640


Glu Glu Ala Gln Lys Leu Leu Glu Gln Tyr Lys Glu Glu Ser Lys Lys 
                645                 650                 655


Ala Leu Pro Pro Glu Lys Lys Gln Asn Thr Gly Ser Lys Lys Ser Asn 
            660                 665                 670


Lys Asn Lys Ser Gly Lys Asn Gln Phe Asn Arg Gly Gly Gly His Arg 
        675                 680                 685


Gly Arg Gly Gly Phe Asn Met Arg Gly Gly Asn Phe Arg Gly Gly Gly 
    690                 695                 700


Asn Pro Trp Glu Ser Trp Arg Ile 
705                 710


<210>  2104
<211>  3977
<212>  DNA
<213>  Homo sapiens

<400>  2104
acgaagagct ggagaaacac ataagaaggc agatctaaga tggaagaaaa ggcggattcg     60

ggttgaaacg ccaagttgag gactgaagaa agcatttgga taaagcagcc tccaagctgg    120

gaaggagaaa agccaaacga gtatagccac caaagaccca gaaaggccaa tatatcatgc    180

agtgagtcgg ttgaactgaa aggcggtttc cttttcctcc atttgctcag tcccaattgg    240

aagcgcactg cgcggcctcc accgcgctct cggcccgggt tcggcgtggg ggcggggagg    300

taagtacggt aatgggcggg gccgagcgcg ggcgcgctcc ggctttcctc ctgcgcagtg    360

ctcccgtcag cgcagggggc ggggcgccta tattacgtgc gcggcgccgc tcctgcgaga    420

ggacgttgcg tgctcgctcg cgccaggcga gtctccgcgt ctccctcgcg aactcggtga    480

aaggaattgg cgccgttcga caccaggcgg atccgctctg cagcacgaac ccatctccag    540

ccgcagccgc agccgccgcc cgggccgagg agcagccgca gcagccgcca ccagtggccg    600

agtgagcgga gccgagtttg aggcagcgcc tagcggtgaa tcggggccct caccatgagt    660

tcctcgcctg ttaatgtaaa aaagctgaag gtgtcggagc tgaaagagga gctcaagaag    720

cgacgccttt ctgacaaggg tctcaaggcc gagctcatgg agcgactcca ggctgcgctg    780

gacgacgagg aggccggggg ccgccccgcc atggagcccg gaacggcgac gatcagggtt    840

tccaggaagg ggaagatgag ctcggggacg aagaggaagg cgcgggcgac gagaacgggc    900

acggggagca gcagcctcaa ccgccggcga cgcagcagca acagccccaa cagcagcgcg    960

gggccgccaa ggaggccgcg gggaagagca gcggccccac ctcgctgttc gcggtgacgg   1020

tggcgccgcc cggggcgagg cagggccagc agcaggcggg aggtaagaag aaggcggaag   1080

gcggcggagg cggcggtcgc cccggggctc cggcggcggg ggacggcaaa acagaacaga   1140

aaggcggaga taaaaagagg ggtgttaaaa gaccacgaga agatcatggc cgtggatatt   1200

ttgagtacat tgaagagaac aagtatagca gagccaaatc tcctcagcca cctgttgaag   1260

aagaagatga acacttcgat gacacagtgg tttgtcttga tacttataat tgtgatctac   1320

attttaaaat atcaagagat cgtctcagtg cttcttccct tacaatggag agttttgctt   1380

ttctttgggc tggaggaaga gcatcctatg gtgtgtcaaa aggcaaagtg tgttttgaga   1440

tgaaggttac agagaagatc ccagtaaggc atttatatac aaaagatatt gacatacatg   1500

aagttcgtat tggctggtca ctaactacaa gtggaatgtt acttggtgaa gaagaatttt   1560

cttatgggta ttctctaaaa ggaataaaaa catgcaactg tgagactgaa gattatggag   1620

aaaagtttga tgaaaatgat gtgattacat gttttgctaa ctttgaaagt gatgaagtag   1680

aactctcgta tgctaagaat ggacaagatc ttggcgttgc cttcaaaatc agtaaggaag   1740

ttcttgctgg acggccactg ttcccgcatg ttctctgcca caactgtgca gttgaattta   1800

attttggtca gaaggaaaag ccatattttc caatacctga agagtatact ttcatccaga   1860

acgtcccctt agaggatcga gttagaggac caaaggggcc tgaagagaag aaagattgtg   1920

aagttgtgat gatgattggc ttgccaggag ctggaaaaac tacctgggtt actaaacatg   1980

cagcagaaaa tccagggaaa tataacattc ttggcacaaa tactattatg gataagatga   2040

tggtggcagg ttttaagaag caaatggcag atactggaaa actgaacaca ctgttgcaga   2100

gagcccccca gtgtcttggg aaatttattg agattgctgc ccgaaagaag cgaaatttta   2160

ttctggatca gacaaatgtg tctgctgctg cccagaggag aaaaatgtgc ctgtttgcag   2220

gcttccagcg aaaagctgtt gtagtttgcc caaaagatga agactataag caaagaacac   2280

agaagaaagc agaagtagag gggaaagacc taccagaaca tgcggtcctc aaaatgaaag   2340

gaaactttac cctcccagag gtagctgagt gctttgatga aataacctat gttgaacttc   2400

agaaggaaga agcccaaaaa ctcttggagc aatataagga agaaagcaaa aaggctcttc   2460

caccagaaaa gaaacagaac actggctcaa agaaaagcaa taaaaataag agtggcaaga   2520

accagtttaa cagaggtggt ggccatagag gacgtggagg attcaatatg cgtggtggaa   2580

atttcagagg aggaggcaac ccctgggaat cgtggcggat ataataggag gggcaacatg   2640

ccacagagag gtggtggcgg tggaggaagt ggtggaatcg gctatccata ccctcgtgcc   2700

cctgtttttc ctggccgtgg tagttactca aacagaggga actacaacag aggtggaatg   2760

cccaacagag ggaactacaa ccagaacttc agaggacgag gaaacaatcg tggctacaaa   2820

aatcaatctc agggctacaa ccagtggcag cagggtcaat tctggggtca gaagccatgg   2880

agtcagcatt atcaccaagg atattattga atacccaaat aaaacgaact gatacatatt   2940

tctccaaaac cttcacaaga agtcgactgt tttctttagt aggctaactt tttaaacatt   3000

ccacaagagg aagtgcctgc gggttccttt tttagaagct ttgtgggttg attttttttc   3060

ttttcttttt tgtacatttt taattgcagt ttaaaagtga atcgtaagag aacctcagca   3120

ttgtgcacga taagagaatg tgtcagtatt tcagggttct acattttatc tgtaaaatgt   3180

gacttttttt tttttttatc acaacagaag taaaatgttg ctttgtacct ggtgtctttt   3240

attaagaatt tactcccccc atttctcaca gagaataaca gtcgggagtc attgtcacaa   3300

tataatagaa atgttagcaa ccagattcat gtaaggacta agtggtcctc atgaattgca   3360

ttaagactct gtactgctca tattacactc catcctctct gtagtttgct gggtagtgga   3420

gggggtaagc taaatcatag tttctgacaa taactgggaa ggttttttct taaaataaca   3480

atggaattgg tataattggg attgaaaact aaaacttgga actaagatag agaagatgga   3540

gtgtatgtag aagggctgtt aaaaatgtaa aacttggttg cattatttgt ggaggctcaa   3600

acttgtgaag gttaatacca taatttttcc atttgttctg cattttgatt ctgaaaagaa   3660

agctggcttt gcccatttct tattaaaaaa acttgttgta aatccagttg tctaatggga   3720

tctatatgaa gttagccatg tctgtatgcc cttctcccac aaaatactgt ataactagtg   3780

tgcttgtagt agttaactcc accatctttg taagctaatg aaattgtgag tcacccattt   3840

atatcttaat ttttaatcat gtcagttctt gaatgggtat ctccttagcc tgctgatttc   3900

tttttctttc taaagaaagt gggtggagaa attaatttag acgtttgttt gcaataaaaa   3960

gaattcattt tactctt                                                  3977


<210>  2105
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  2105

Met Glu Ser Phe Ala Phe Leu Trp Ala Gly Gly Arg Ala Ser Tyr Gly 
1               5                   10                  15


Val Ser Lys Gly Lys Val Cys Phe Glu Met Lys Val Thr Glu Lys Ile 
            20                  25                  30


Pro Val Arg His Leu Tyr Thr Lys Asp Ile Asp Ile His Glu Val Arg 
        35                  40                  45


Ile Gly Trp Ser Leu Thr Thr Ser Gly Met Leu Leu Gly Glu Glu Glu 
    50                  55                  60


Phe Ser Tyr Gly Tyr Ser Leu Lys Gly Ile Lys Thr Cys Asn Cys Glu 
65                  70                  75                  80


Thr Glu Asp Tyr Gly Glu Lys Phe Asp Glu Asn Asp Val Ile Thr Cys 
                85                  90                  95


Phe Ala Asn Phe Glu Ser Asp Glu Val Glu Leu Ser Tyr Ala Lys Asn 
            100                 105                 110


Gly Gln Asp Leu Gly Val Ala Phe Lys Ile Ser Lys Glu Val Leu Ala 
        115                 120                 125


Gly Arg Pro Leu Phe Pro His Val Leu Cys His Asn Cys Ala Val Glu 
    130                 135                 140


Phe Asn Phe Gly Gln Lys Glu Lys Pro Tyr Phe Pro Ile Pro Glu Glu 
145                 150                 155                 160


Tyr Thr Phe Ile Gln Asn Val Pro Leu Glu Asp Arg Val Arg Gly Pro 
                165                 170                 175


Lys Gly Pro Glu Glu Lys Lys Asp Cys Glu Val Val Met Met Ile Gly 
            180                 185                 190


Leu Pro Gly Ala Gly Lys Thr Thr Trp Val Thr Lys His Ala Ala Glu 
        195                 200                 205


Asn Pro Gly Lys Tyr Asn Ile Leu Gly Thr Asn Thr Ile Met Asp Lys 
    210                 215                 220


Met Met Val Ala Gly Phe Lys Lys Gln Met Ala Asp Thr Gly Lys Leu 
225                 230                 235                 240


Asn Thr Leu Leu Gln Arg Ala Pro Gln Cys Leu Gly Lys Phe Ile Glu 
                245                 250                 255


Ile Ala Ala Arg Lys Lys Arg Asn Phe Ile Leu Asp Gln Thr Asn Val 
            260                 265                 270


Ser Ala Ala Ala Gln Arg Arg Lys Met Cys Leu Phe Ala Gly Phe Gln 
        275                 280                 285


Arg Lys Ala Val Val Val Cys Pro Lys Asp Glu Asp Tyr Lys Gln Arg 
    290                 295                 300


Thr Gln Lys Lys Ala Glu Val Glu Gly Lys Asp Leu Pro Glu His Ala 
305                 310                 315                 320


Val Leu Lys Met Lys Gly Asn Phe Thr Leu Pro Glu Val Ala Glu Cys 
                325                 330                 335


Phe Asp Glu Ile Thr Tyr Val Glu Leu Gln Lys Glu Glu Ala Gln Lys 
            340                 345                 350


Leu Leu Glu Gln Tyr Lys Glu Glu Ser Lys Lys Ala Leu Pro Pro Glu 
        355                 360                 365


Lys Lys Gln Asn Thr Gly Ser Lys Lys Ser Asn Lys Asn Lys Ser Gly 
    370                 375                 380


Lys Asn Gln Phe Asn Arg Gly Gly Gly His Arg Gly Arg Gly Gly Phe 
385                 390                 395                 400


Asn Met Arg Gly Gly Asn Phe Arg Gly Gly Gly Asn Pro Trp Glu Ser 
                405                 410                 415


Trp Arg Ile 



<210>  2106
<211>  4203
<212>  DNA
<213>  Homo sapiens

<400>  2106
acgaagagct ggagaaacac ataagaaggc agatctaaga tggaagaaaa ggcggattcg     60

ggttgaaacg ccaagttgag gactgaagaa agcatttgga taaagcagcc tccaagctgg    120

gaaggagaaa agccaaacga gtatagccac caaagaccca gaaaggccaa tatatcatgc    180

agtgagtcgg ttgaactgaa aggcggtttc cttttcctcc atttgctcag tcccaattgg    240

aagcgcactg cgcggcctcc accgcgctct cggcccgggt tcggcgtggg ggcggggagg    300

taagtacggt aatgggcggg gccgagcgcg ggcgcgctcc ggctttcctc ctgcgcagtg    360

ctcccgtcag cgcagggggc ggggcgccta tattacgtgc gcggcgccgc tcctgcgaga    420

ggacgttgcg tgctcgctcg cgccaggcga gtctccgcgt ctccctcgcg aactcggtga    480

aaggaattgg cgccgttcga caccaggcgg atccgctctg cagcacgaac ccatctccag    540

ccgcagccgc agccgccgcc cgggccgagg agcagccgca gcagccgcca ccagtggccg    600

agtgagcgga gccgagtttg aggcagcgcc tagcggtgaa tcggggccct caccatgagt    660

tcctcgcctg ttaatgtaaa aaagctgaag gtgtcggagc tgaaagagga gctcaagaag    720

cgacgccttt ctgacaaggg tctcaaggcc gagctcatgg agcgactcca ggctgcgctg    780

gacgacgagg aggccggggg ccgccccgcc atggagcccg ggaacggcag cctagacctg    840

ggcggggatt ccgctgggcg ctcgggagca ggcctcgagc aggaggccgc ggccggcggc    900

gatgaagagg aggaggaaga ggaagaggag gaggaaggaa tctccgctct ggacggcgac    960

cagatggagc taggagagga gaacggggcc gcgggggcgg ccgactcggg cccgatggag   1020

gaggaggagg ccgcctcgga agacgagaac ggcgacgatc agggtttcca ggaaggggaa   1080

gatgagctcg gggacgaaga ggaaggcgcg ggcgacgaga acgggcacgg ggagcagcag   1140

cctcaaccgc cggcgacgca gcagcaacag ccccaacagc agcgcggggc cgccaaggag   1200

gccgcgggga agagcagcgg ccccacctcg ctgttcgcgg tgacggtggc gccgcccggg   1260

gcgaggcagg gccagcagca ggcgggaggt aagaagaagg cggaaggcgg cggaggcggc   1320

ggtcgccccg gggctccggc ggcgggggac ggcaaaacag aacagaaagg cggagataaa   1380

aagaggggtg ttaaaagacc acgagaagat catggccgtg gatattttga gtacattgaa   1440

gagaacaagt atagcagagc caaatctcct cagccacctg ttgaagaaga agatgaacac   1500

ttcgatgaca cagtggtttg tcttgatact tataattgtg atctacattt taaaatatca   1560

agagatcgtc tcagtgcttc ttcccttaca atggagagtt ttgcttttct ttgggctgga   1620

ggaagagcat cctatggtgt gtcaaaaggc aaagtgtgtt ttgagatgaa ggttacagag   1680

aagatcccag taaggcattt atatacaaaa gatattgaca tacatgaagt tcgtattggc   1740

tggtcactaa ctacaagtgg aatgttactt ggtgaagaag aattttctta tgggtattct   1800

ctaaaaggaa taaaaacatg caactgtgag actgaagatt atggagaaaa gtttgatgaa   1860

aatgatgtga ttacatgttt tgctaacttt gaaagtgatg aagtagaact ctcgtatgct   1920

aagaatggac aagatcttgg cgttgccttc aaaatcagta aggaagttct tgctggacgg   1980

ccactgttcc cgcatgttct ctgccacaac tgtgcagttg aatttaattt tggtcagaag   2040

gaaaagccat attttccaat acctgaagag tatactttca tccagaacgt ccccttagag   2100

gatcgagtta gaggaccaaa ggggcctgaa gagaagaaag attgtgaagt tgtgatgatg   2160

attggcttgc caggagctgg aaaaactacc tgggttacta aacatgcagc agaaaatcca   2220

gggaaatata acattcttgg cacaaatact attatggata agatgatggt ggcaggtttt   2280

aagaagcaaa tggcagatac tggaaaactg aacacactgt tgcagagagc cccccagtgt   2340

cttgggaaat ttattgagat tgctgcccga aagaagcgaa attttattct ggatcagaca   2400

aatgtgtctg ctgctgccca gaggagaaaa atgtgcctgt ttgcaggctt ccagcgaaaa   2460

gctgttgtag tttgcccaaa agatgaagac tataagcaaa gaacacagaa gaaagcagaa   2520

gtagagggga aagacctacc agaacatgcg gtcctcaaaa tgaaaggaaa ctttaccctc   2580

ccagaggtag ctgagtgctt tgatgaaata acctatgttg aacttcagaa ggaagaagcc   2640

caaaaactct tggagcaata taaggaagaa agcaaaaagg ctcttccacc agaaaagaaa   2700

cagaacactg gctcaaagaa aagcaataaa aataagagtg gcaagaacca gtttaacaga   2760

ggtggtggcc atagaggacg tggaggattc aatatgcgtg gtggaaattt cagaggagga   2820

ggcaacccct gggaatcgtg gcggatataa taggaggggc aacatgccac agagaggtgg   2880

tggcggtgga ggaagtggtg gaatcggcta tccataccct cgtgcccctg tttttcctgg   2940

ccgtggtagt tactcaaaca gagggaacta caacagaggt ggaatgccca acagagggaa   3000

ctacaaccag aacttcagag gacgaggaaa caatcgtggc tacaaaaatc aatctcaggg   3060

ctacaaccag tggcagcagg gtcaattctg gggtcagaag ccatggagtc agcattatca   3120

ccaaggatat tattgaatac ccaaataaaa cgaactgata catatttctc caaaaccttc   3180

acaagaagtc gactgttttc tttagtaggc taacttttta aacattccac aagaggaagt   3240

gcctgcgggt tcctttttta gaagctttgt gggttgattt tttttctttt cttttttgta   3300

catttttaat tgcagtttaa aagtgaatcg taagagaacc tcagcattgt gcacgataag   3360

agaatgtgtc agtatttcag ggttctacat tttatctgta aaatgtgact tttttttttt   3420

tttatcacaa cagaagtaaa atgttgcttt gtacctggtg tcttttatta agaatttact   3480

ccccccattt ctcacagaga ataacagtcg ggagtcattg tcacaatata atagaaatgt   3540

tagcaaccag attcatgtaa ggactaagtg gtcctcatga attgcattaa gactctgtac   3600

tgctcatatt acactccatc ctctctgtag tttgctgggt agtggagggg gtaagctaaa   3660

tcatagtttc tgacaataac tgggaaggtt ttttcttaaa ataacaatgg aattggtata   3720

attgggattg aaaactaaaa cttggaacta agatagagaa gatggagtgt atgtagaagg   3780

gctgttaaaa atgtaaaact tggttgcatt atttgtggag gctcaaactt gtgaaggtta   3840

ataccataat ttttccattt gttctgcatt ttgattctga aaagaaagct ggctttgccc   3900

atttcttatt aaaaaaactt gttgtaaatc cagttgtcta atgggatcta tatgaagtta   3960

gccatgtctg tatgcccttc tcccacaaaa tactgtataa ctagtgtgct tgtagtagtt   4020

aactccacca tctttgtaag ctaatgaaat tgtgagtcac ccatttatat cttaattttt   4080

aatcatgtca gttcttgaat gggtatctcc ttagcctgct gatttctttt tctttctaaa   4140

gaaagtgggt ggagaaatta atttagacgt ttgtttgcaa taaaaagaat tcattttact   4200

ctt                                                                 4203


<210>  2107
<211>  731
<212>  PRT
<213>  Homo sapiens

<400>  2107

Met Ser Ser Ser Pro Val Asn Val Lys Lys Leu Lys Val Ser Glu Leu 
1               5                   10                  15


Lys Glu Glu Leu Lys Lys Arg Arg Leu Ser Asp Lys Gly Leu Lys Ala 
            20                  25                  30


Glu Leu Met Glu Arg Leu Gln Ala Ala Leu Asp Asp Glu Glu Ala Gly 
        35                  40                  45


Gly Arg Pro Ala Met Glu Pro Gly Asn Gly Ser Leu Asp Leu Gly Gly 
    50                  55                  60


Asp Ser Ala Gly Arg Ser Gly Ala Gly Leu Glu Gln Glu Ala Ala Ala 
65                  70                  75                  80


Gly Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ile 
                85                  90                  95


Ser Ala Leu Asp Gly Asp Gln Met Glu Leu Gly Glu Glu Asn Gly Ala 
            100                 105                 110


Ala Gly Ala Ala Asp Ser Gly Pro Met Glu Glu Glu Glu Ala Ala Ser 
        115                 120                 125


Glu Asp Glu Asn Gly Asp Asp Gln Gly Phe Gln Glu Gly Glu Asp Glu 
    130                 135                 140


Leu Gly Asp Glu Glu Glu Gly Ala Gly Asp Glu Asn Gly His Gly Glu 
145                 150                 155                 160


Gln Gln Pro Gln Pro Pro Ala Thr Gln Gln Gln Gln Pro Gln Gln Gln 
                165                 170                 175


Arg Gly Ala Ala Lys Glu Ala Ala Gly Lys Ser Ser Gly Pro Thr Ser 
            180                 185                 190


Leu Phe Ala Val Thr Val Ala Pro Pro Gly Ala Arg Gln Gly Gln Gln 
        195                 200                 205


Gln Ala Gly Gly Lys Lys Lys Ala Glu Gly Gly Gly Gly Gly Gly Arg 
    210                 215                 220


Pro Gly Ala Pro Ala Ala Gly Asp Gly Lys Thr Glu Gln Lys Gly Gly 
225                 230                 235                 240


Asp Lys Lys Arg Gly Val Lys Arg Pro Arg Glu Asp His Gly Arg Gly 
                245                 250                 255


Tyr Phe Glu Tyr Ile Glu Glu Asn Lys Tyr Ser Arg Ala Lys Ser Pro 
            260                 265                 270


Gln Pro Pro Val Glu Glu Glu Asp Glu His Phe Asp Asp Thr Val Val 
        275                 280                 285


Cys Leu Asp Thr Tyr Asn Cys Asp Leu His Phe Lys Ile Ser Arg Asp 
    290                 295                 300


Arg Leu Ser Ala Ser Ser Leu Thr Met Glu Ser Phe Ala Phe Leu Trp 
305                 310                 315                 320


Ala Gly Gly Arg Ala Ser Tyr Gly Val Ser Lys Gly Lys Val Cys Phe 
                325                 330                 335


Glu Met Lys Val Thr Glu Lys Ile Pro Val Arg His Leu Tyr Thr Lys 
            340                 345                 350


Asp Ile Asp Ile His Glu Val Arg Ile Gly Trp Ser Leu Thr Thr Ser 
        355                 360                 365


Gly Met Leu Leu Gly Glu Glu Glu Phe Ser Tyr Gly Tyr Ser Leu Lys 
    370                 375                 380


Gly Ile Lys Thr Cys Asn Cys Glu Thr Glu Asp Tyr Gly Glu Lys Phe 
385                 390                 395                 400


Asp Glu Asn Asp Val Ile Thr Cys Phe Ala Asn Phe Glu Ser Asp Glu 
                405                 410                 415


Val Glu Leu Ser Tyr Ala Lys Asn Gly Gln Asp Leu Gly Val Ala Phe 
            420                 425                 430


Lys Ile Ser Lys Glu Val Leu Ala Gly Arg Pro Leu Phe Pro His Val 
        435                 440                 445


Leu Cys His Asn Cys Ala Val Glu Phe Asn Phe Gly Gln Lys Glu Lys 
    450                 455                 460


Pro Tyr Phe Pro Ile Pro Glu Glu Tyr Thr Phe Ile Gln Asn Val Pro 
465                 470                 475                 480


Leu Glu Asp Arg Val Arg Gly Pro Lys Gly Pro Glu Glu Lys Lys Asp 
                485                 490                 495


Cys Glu Val Val Met Met Ile Gly Leu Pro Gly Ala Gly Lys Thr Thr 
            500                 505                 510


Trp Val Thr Lys His Ala Ala Glu Asn Pro Gly Lys Tyr Asn Ile Leu 
        515                 520                 525


Gly Thr Asn Thr Ile Met Asp Lys Met Met Val Ala Gly Phe Lys Lys 
    530                 535                 540


Gln Met Ala Asp Thr Gly Lys Leu Asn Thr Leu Leu Gln Arg Ala Pro 
545                 550                 555                 560


Gln Cys Leu Gly Lys Phe Ile Glu Ile Ala Ala Arg Lys Lys Arg Asn 
                565                 570                 575


Phe Ile Leu Asp Gln Thr Asn Val Ser Ala Ala Ala Gln Arg Arg Lys 
            580                 585                 590


Met Cys Leu Phe Ala Gly Phe Gln Arg Lys Ala Val Val Val Cys Pro 
        595                 600                 605


Lys Asp Glu Asp Tyr Lys Gln Arg Thr Gln Lys Lys Ala Glu Val Glu 
    610                 615                 620


Gly Lys Asp Leu Pro Glu His Ala Val Leu Lys Met Lys Gly Asn Phe 
625                 630                 635                 640


Thr Leu Pro Glu Val Ala Glu Cys Phe Asp Glu Ile Thr Tyr Val Glu 
                645                 650                 655


Leu Gln Lys Glu Glu Ala Gln Lys Leu Leu Glu Gln Tyr Lys Glu Glu 
            660                 665                 670


Ser Lys Lys Ala Leu Pro Pro Glu Lys Lys Gln Asn Thr Gly Ser Lys 
        675                 680                 685


Lys Ser Asn Lys Asn Lys Ser Gly Lys Asn Gln Phe Asn Arg Gly Gly 
    690                 695                 700


Gly His Arg Gly Arg Gly Gly Phe Asn Met Arg Gly Gly Asn Phe Arg 
705                 710                 715                 720


Gly Gly Gly Asn Pro Trp Glu Ser Trp Arg Ile 
                725                 730


<210>  2108
<211>  1932
<212>  DNA
<213>  Homo sapiens

<400>  2108
acgaagagct ggagaaacac ataagaaggc agatctaaga tggaagaaaa ggcggattcg     60

ggttgaaacg ccaagttgag gactgaagaa agcatttgga taaagcagcc tccaagctgg    120

gaaggagaaa agccaaacga gtatagccac caaagaccca gaaaggccaa tatatcatgc    180

agtgagtcgg ttgaactgaa aggcggtttc cttttcctcc atttgctcag tcccaattgg    240

aagcgcactg cgcggcctcc accgcgctct cggcccgggt tcggcgtggg ggcggggagg    300

taagtacggt aatgggcggg gccgagcgcg ggcgcgctcc ggctttcctc ctgcgcagtg    360

ctcccgtcag cgcagggggc ggggcgccta tattacgtgc gcggcgccgc tcctgcgaga    420

ggacgttgcg tgctcgctcg cgccaggcga gtctccgcgt ctccctcgcg aactcggtga    480

aaggaattgg cgccgttcga caccaggcgg atccgctctg cagcacgaac ccatctccag    540

ccgcagccgc agcccccctg ggaatcgtgg cggatataat aggaggggca acatgccaca    600

gagaggtggt ggcggtggag gaagtggtgg aatcggctat ccataccctc gtgcccctgt    660

ttttcctggc cgtggtagtt actcaaacag agggaactac aacagaggtg gaatgcccaa    720

cagagggaac tacaaccaga acttcagagg acgaggaaac aatcgtggct acaaaaatca    780

atctcagggc tacaaccagt ggcagcaggg tcaattctgg ggtcagaagc catggagtca    840

gcattatcac caaggatatt attgaatacc caaataaaac gaactgatac atatttctcc    900

aaaaccttca caagaagtcg actgttttct ttagtaggct aactttttaa acattccaca    960

agaggaagtg cctgcgggtt ccttttttag aagctttgtg ggttgatttt ttttcttttc   1020

ttttttgtac atttttaatt gcagtttaaa agtgaatcgt aagagaacct cagcattgtg   1080

cacgataaga gaatgtgtca gtatttcagg gttctacatt ttatctgtaa aatgtgactt   1140

tttttttttt ttatcacaac agaagtaaaa tgttgctttg tacctggtgt cttttattaa   1200

gaatttactc cccccatttc tcacagagaa taacagtcgg gagtcattgt cacaatataa   1260

tagaaatgtt agcaaccaga ttcatgtaag gactaagtgg tcctcatgaa ttgcattaag   1320

actctgtact gctcatatta cactccatcc tctctgtagt ttgctgggta gtggaggggg   1380

taagctaaat catagtttct gacaataact gggaaggttt tttcttaaaa taacaatgga   1440

attggtataa ttgggattga aaactaaaac ttggaactaa gatagagaag atggagtgta   1500

tgtagaaggg ctgttaaaaa tgtaaaactt ggttgcatta tttgtggagg ctcaaacttg   1560

tgaaggttaa taccataatt tttccatttg ttctgcattt tgattctgaa aagaaagctg   1620

gctttgccca tttcttatta aaaaaacttg ttgtaaatcc agttgtctaa tgggatctat   1680

atgaagttag ccatgtctgt atgcccttct cccacaaaat actgtataac tagtgtgctt   1740

gtagtagtta actccaccat ctttgtaagc taatgaaatt gtgagtcacc catttatatc   1800

ttaattttta atcatgtcag ttcttgaatg ggtatctcct tagcctgctg atttcttttt   1860

ctttctaaag aaagtgggtg gagaaattaa tttagacgtt tgtttgcaat aaaaagaatt   1920

cattttactc tt                                                       1932


<210>  2109
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  2109

Met Gly Gly Ala Glu Arg Gly Arg Ala Pro Ala Phe Leu Leu Arg Ser 
1               5                   10                  15


Ala Pro Val Ser Ala Gly Gly Gly Ala Pro Ile Leu Arg Ala Arg Arg 
            20                  25                  30


Arg Ser Cys Glu Arg Thr Leu Arg Ala Arg Ser Arg Gln Ala Ser Leu 
        35                  40                  45


Arg Val Ser Leu Ala Asn Ser Val Lys Gly Ile Gly Ala Val Arg His 
    50                  55                  60


Gln Ala Asp Pro Leu Cys Ser Thr Asn Pro Ser Pro Ala Ala Ala Ala 
65                  70                  75                  80


Ala Pro Leu Gly Ile Val Ala Asp Ile Ile Gly Gly Ala Thr Cys His 
                85                  90                  95


Arg Glu Val Val Ala Val Glu Glu Val Val Glu Ser Ala Ile His Thr 
            100                 105                 110


Leu Val Pro Leu Phe Phe Leu Ala Val Val Val Thr Gln Thr Glu Gly 
        115                 120                 125


Thr Thr Thr Glu Val Glu Cys Pro Thr Glu Gly Thr Thr Thr Arg Thr 
    130                 135                 140


Ser Glu Asp Glu Glu Thr Ile Val Ala Thr Lys Ile Asn Leu Arg Ala 
145                 150                 155                 160


Thr Thr Ser Gly Ser Arg Val Asn Ser Gly Val Arg Ser His Gly Val 
                165                 170                 175


Ser Ile Ile Thr Lys Asp Ile Ile Glu Tyr Pro Asn Lys Thr Asn 
            180                 185                 190


<210>  2110
<211>  3874
<212>  DNA
<213>  Homo sapiens

<400>  2110
acgaagagct ggagaaacac ataagaaggc agatctaaga tggaagaaaa ggcggattcg     60

ggttgaaacg ccaagttgag gactgaagaa agcatttgga taaagcagcc tccaagctgg    120

gaaggagaaa agccaaacga gtatagccac caaagaccca gaaaggccaa tatatcatgc    180

agtgagtcgg ttgaactgaa aggcggtttc cttttcctcc atttgctcag tcccaattgg    240

aagcgcactg cgcggcctcc accgcgctct cggcccgggt tcggcgtggg ggcggggagg    300

taagtacggt aatgggcggg gccgagcgcg ggcgcgctcc ggctttcctc ctgcgcagtg    360

ctcccgtcag cgcagggggc ggggcgccta tattacgtgc gcggcgccgc tcctgcgaga    420

ggacgttgcg tgctcgctcg cgccaggcga gtctccgcgt ctccctcgcg aactcggtga    480

aaggaattgg cgccgttcga caccaggcgg atccgctctg cagcacgaac ccatctccag    540

ccgcagccgc agccgccgcc cgggccgagg agcagccgca gcagccgcca ccagtggccg    600

agtgagcgga gccgagtttg aggcagcgcc tagcggtgaa tcggggccct caccatgagt    660

tcctcgcctg ttaatgtaaa aaagctgaag gtgtcggagc tgaaagagga gctcaagaag    720

cgacgccttt ctgacaaggg tctcaaggcc gagctcatgg agcgactcca ggctgcgctg    780

gacgacgagg aggccggggg ccgccccgcc atggagcccg ggaacggcag cctagacctg    840

ggcggggatt ccgctgggcg ctcgggagca ggcctcgagc aggaggccgc ggccggcggc    900

gatgaagagg aggaggaaga ggaagaggag gaggaaggaa tctccgctct ggacggcgac    960

cagatggagc taggagagga gaacggggcc gcgggggcgg ccgactcggg cccgatggag   1020

gaggaggagg ccgcctcgga agacgagaac ggcgacgatc agggtttcca ggaaggggaa   1080

gatgagctcg gggacgaaga ggaaggcgcg ggcgacgaga acgggcacgg ggagcagcag   1140

cctcaaccgc cggcgacgca gcagcaacag ccccaacagc agcgcggggc cgccaaggag   1200

gccgcgggga agagcagcgg ccccacctcg ctgttcgcgg tgacggtggc gccgcccggg   1260

gcgaggcagg gccagcagca ggcgggaggg gacggcaaaa cagaacagaa aggcggagat   1320

aaaaagaggg gtgttaaaag accacgagaa gatcatggcc gtggatattt tgagtacatt   1380

gaagagaaca agtatagcag agccaaatct cctcagccac ctgttgaaga agaagatgaa   1440

cacttcgatg acacagtggt ttgtcttgat acttataatt gtgatctaca ttttaaaata   1500

tcaagagatc gtctcagtgc ttcttccctt acaatggaga gttttgcttt tctttgggct   1560

ggaggaagag catcctatgg tgtgtcaaaa ggcaaagtgt gttttgagat gaaggttaca   1620

gagaagatcc cagtaaggca tttatataca aaagatattg acatacatga agttcgtatt   1680

ggctggtcac taactacaag tggaatgtta cttggtgaag aagaattttc ttatgggtat   1740

tctctaaaag gaataaaaac atgcaactgt gagactgaag attatggaga aaagtttgat   1800

gaaaatgatg tgattacatg ttttgctaac tttgaaagtg atgaagtaga actctcgtat   1860

gctaagaatg gacaagatct tggcgttgcc ttcaaaatca gtaaggaagt tcttgctgga   1920

cggccactgt tcccgcatgt tctctgccac aactgtgcag ttgaatttaa ttttggtcag   1980

aaggaaaagc catattttcc aatacctgaa gagtatactt tcatccagaa cgtcccctta   2040

gaggatcgag ttagaggacc aaaggggcct gaagagaaga aagattgtga agttgtgatg   2100

atgattggct tgccaggagc tggaaaaact acctgggtta ctaaacatgc agcagaaaat   2160

ccagggaaat ataacattct tggcacaaat actattatgg ataagatgat ggtggcaggt   2220

tttaagaagc aaatggcaga tactggaaaa ctgaacacac tgttgcagag agccccccag   2280

tgtcttggga aatttattga gattgctgcc cgaaagaagc gaaattttat tctggatcag   2340

acaaatgtgt ctgctgctgc ccagaggaga aaaatgtgcc tgtttgcagg cttccagcga   2400

aaagctgttg tagtttgccc aaaagatgaa gactataagc aaagaacaca gaagaaagca   2460

gaagtagagg ggaaagacct accagaacat gcggtcctca aaatgaaagg aaactttacc   2520

ctcccagagg tagctgagtg ctttgatgaa ataacctatg ttgaacttca gaaggaagaa   2580

gcccaaaaac tcttggagca atataaggaa gaaagcaaaa aggctcttcc accagaaaag   2640

aaacagaaca ctggctcaaa gaaaagcaat aaaaataaga gtggcaagaa ccagtttaac   2700

agaggtggtg gccatagagg acgtggagga ttcaatatgc gtggtggaaa tttcagagga   2760

ggaggcaacc cctgggaatc gtggcggata taataggagg ggcaacatgc cacagagagg   2820

tggtggcggt ggaggaagtg gtggaatcgg ctatccatac cctcgtgccc ctgtttttcc   2880

tggccgtggt agttactcaa acagagggaa ctacaacaga ggtggaatgc ccaacagagg   2940

gaactacaac cagaacttca gaggacgagg aaacaatcgt ggctacaaaa atcaatctca   3000

gggctacaac cagtggcagc agggtcaatt ctggggtcag aagccatgga gtcagcatta   3060

tcaccaagga tattattgaa tacccaaata aaacgaactg atacatattt ctccaaaacc   3120

ttcacaagaa gtcgactgtt ttctttagta ggctaacttt ttaaacattc cacaagagga   3180

agtgcctgcg ggttcctttt ttagaagctt tgtgggttga ttttttttct tttctttttt   3240

gtacattttt aattgcagtt taaaagtgaa tcgtaagaga acctcagcat tgtgcacgat   3300

aagagaatgt gtcagtattt cagggttcta cattttatct gtaaaatgtg actttttttt   3360

ttttttatca caacagaagt aaaatgttgc tttgtacctg gtgtctttta ttaagaattt   3420

actcccccca tttctcacag agaataacag tcgggagtca ttgtcacaat ataatagaaa   3480

tgttagcaac cagattcatg taaggactaa gtggtcctca tgaattgcat taagactctg   3540

tactgctcat attacactcc atcctctctg tagtttgctg ggtagtggag ggggtaagct   3600

aaatcatagt ttctgacaat aactgggaag gttttttctt aaaataacaa tggaattggt   3660

ataattggga ttgaaaacta aaacttggaa ctaagataga gaagatggag tgtatgtaga   3720

agggctgtta aaaatgtaaa acttggttgc attatttgtg gaggctcaaa cttgtgaagg   3780

ttaataccat aatttttcca tttgttctgc attttgattc tgaaaagaaa gctggctttg   3840

cccatttctt attaaaaaaa cttgttgtaa atcc                               3874


<210>  2111
<211>  712
<212>  PRT
<213>  Homo sapiens

<400>  2111

Met Ser Ser Ser Pro Val Asn Val Lys Lys Leu Lys Val Ser Glu Leu 
1               5                   10                  15


Lys Glu Glu Leu Lys Lys Arg Arg Leu Ser Asp Lys Gly Leu Lys Ala 
            20                  25                  30


Glu Leu Met Glu Arg Leu Gln Ala Ala Leu Asp Asp Glu Glu Ala Gly 
        35                  40                  45


Gly Arg Pro Ala Met Glu Pro Gly Asn Gly Ser Leu Asp Leu Gly Gly 
    50                  55                  60


Asp Ser Ala Gly Arg Ser Gly Ala Gly Leu Glu Gln Glu Ala Ala Ala 
65                  70                  75                  80


Gly Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ile 
                85                  90                  95


Ser Ala Leu Asp Gly Asp Gln Met Glu Leu Gly Glu Glu Asn Gly Ala 
            100                 105                 110


Ala Gly Ala Ala Asp Ser Gly Pro Met Glu Glu Glu Glu Ala Ala Ser 
        115                 120                 125


Glu Asp Glu Asn Gly Asp Asp Gln Gly Phe Gln Glu Gly Glu Asp Glu 
    130                 135                 140


Leu Gly Asp Glu Glu Glu Gly Ala Gly Asp Glu Asn Gly His Gly Glu 
145                 150                 155                 160


Gln Gln Pro Gln Pro Pro Ala Thr Gln Gln Gln Gln Pro Gln Gln Gln 
                165                 170                 175


Arg Gly Ala Ala Lys Glu Ala Ala Gly Lys Ser Ser Gly Pro Thr Ser 
            180                 185                 190


Leu Phe Ala Val Thr Val Ala Pro Pro Gly Ala Arg Gln Gly Gln Gln 
        195                 200                 205


Gln Ala Gly Gly Asp Gly Lys Thr Glu Gln Lys Gly Gly Asp Lys Lys 
    210                 215                 220


Arg Gly Val Lys Arg Pro Arg Glu Asp His Gly Arg Gly Tyr Phe Glu 
225                 230                 235                 240


Tyr Ile Glu Glu Asn Lys Tyr Ser Arg Ala Lys Ser Pro Gln Pro Pro 
                245                 250                 255


Val Glu Glu Glu Asp Glu His Phe Asp Asp Thr Val Val Cys Leu Asp 
            260                 265                 270


Thr Tyr Asn Cys Asp Leu His Phe Lys Ile Ser Arg Asp Arg Leu Ser 
        275                 280                 285


Ala Ser Ser Leu Thr Met Glu Ser Phe Ala Phe Leu Trp Ala Gly Gly 
    290                 295                 300


Arg Ala Ser Tyr Gly Val Ser Lys Gly Lys Val Cys Phe Glu Met Lys 
305                 310                 315                 320


Val Thr Glu Lys Ile Pro Val Arg His Leu Tyr Thr Lys Asp Ile Asp 
                325                 330                 335


Ile His Glu Val Arg Ile Gly Trp Ser Leu Thr Thr Ser Gly Met Leu 
            340                 345                 350


Leu Gly Glu Glu Glu Phe Ser Tyr Gly Tyr Ser Leu Lys Gly Ile Lys 
        355                 360                 365


Thr Cys Asn Cys Glu Thr Glu Asp Tyr Gly Glu Lys Phe Asp Glu Asn 
    370                 375                 380


Asp Val Ile Thr Cys Phe Ala Asn Phe Glu Ser Asp Glu Val Glu Leu 
385                 390                 395                 400


Ser Tyr Ala Lys Asn Gly Gln Asp Leu Gly Val Ala Phe Lys Ile Ser 
                405                 410                 415


Lys Glu Val Leu Ala Gly Arg Pro Leu Phe Pro His Val Leu Cys His 
            420                 425                 430


Asn Cys Ala Val Glu Phe Asn Phe Gly Gln Lys Glu Lys Pro Tyr Phe 
        435                 440                 445


Pro Ile Pro Glu Glu Tyr Thr Phe Ile Gln Asn Val Pro Leu Glu Asp 
    450                 455                 460


Arg Val Arg Gly Pro Lys Gly Pro Glu Glu Lys Lys Asp Cys Glu Val 
465                 470                 475                 480


Val Met Met Ile Gly Leu Pro Gly Ala Gly Lys Thr Thr Trp Val Thr 
                485                 490                 495


Lys His Ala Ala Glu Asn Pro Gly Lys Tyr Asn Ile Leu Gly Thr Asn 
            500                 505                 510


Thr Ile Met Asp Lys Met Met Val Ala Gly Phe Lys Lys Gln Met Ala 
        515                 520                 525


Asp Thr Gly Lys Leu Asn Thr Leu Leu Gln Arg Ala Pro Gln Cys Leu 
    530                 535                 540


Gly Lys Phe Ile Glu Ile Ala Ala Arg Lys Lys Arg Asn Phe Ile Leu 
545                 550                 555                 560


Asp Gln Thr Asn Val Ser Ala Ala Ala Gln Arg Arg Lys Met Cys Leu 
                565                 570                 575


Phe Ala Gly Phe Gln Arg Lys Ala Val Val Val Cys Pro Lys Asp Glu 
            580                 585                 590


Asp Tyr Lys Gln Arg Thr Gln Lys Lys Ala Glu Val Glu Gly Lys Asp 
        595                 600                 605


Leu Pro Glu His Ala Val Leu Lys Met Lys Gly Asn Phe Thr Leu Pro 
    610                 615                 620


Glu Val Ala Glu Cys Phe Asp Glu Ile Thr Tyr Val Glu Leu Gln Lys 
625                 630                 635                 640


Glu Glu Ala Gln Lys Leu Leu Glu Gln Tyr Lys Glu Glu Ser Lys Lys 
                645                 650                 655


Ala Leu Pro Pro Glu Lys Lys Gln Asn Thr Gly Ser Lys Lys Ser Asn 
            660                 665                 670


Lys Asn Lys Ser Gly Lys Asn Gln Phe Asn Arg Gly Gly Gly His Arg 
        675                 680                 685


Gly Arg Gly Gly Phe Asn Met Arg Gly Gly Asn Phe Arg Gly Gly Gly 
    690                 695                 700


Asn Pro Trp Glu Ser Trp Arg Ile 
705                 710


<210>  2112
<211>  3931
<212>  DNA
<213>  Homo sapiens

<400>  2112
acgaagagct ggagaaacac ataagaaggc agatctaaga tggaagaaaa ggcggattcg     60

ggttgaaacg ccaagttgag gactgaagaa agcatttgga taaagcagcc tccaagctgg    120

gaaggagaaa agccaaacga gtatagccac caaagaccca gaaaggccaa tatatcatgc    180

agtgagtcgg ttgaactgaa aggcggtttc cttttcctcc atttgctcag tcccaattgg    240

aagcgcactg cgcggcctcc accgcgctct cggcccgggt tcggcgtggg ggcggggagg    300

taagtacggt aatgggcggg gccgagcgcg ggcgcgctcc ggctttcctc ctgcgcagtg    360

ctcccgtcag cgcagggggc ggggcgccta tattacgtgc gcggcgccgc tcctgcgaga    420

ggacgttgcg tgctcgctcg cgccaggcga gtctccgcgt ctccctcgcg aactcggtga    480

aaggaattgg cgccgttcga caccaggcgg atccgctctg cagcacgaac ccatctccag    540

ccgcagccgc agccgccgcc cgggccgagg agcagccgca gcagccgcca ccagtggccg    600

agtgagcgga gccgagtttg aggcagcgcc tagcggtgaa tcggggccct caccatgagt    660

tcctcgcctg ttaatgtaaa aaagctgaag gtgtcggagc tgaaagagga gctcaagaag    720

cgacgccttt ctgacaaggg tctcaaggcc gagctcatgg agcgactcca ggctgcgctg    780

gacgacgagg aggccggggg ccgccccgcc atggagcccg ggaacggcag cctagacctg    840

ggcggggatt ccgctgggcg ctcgggagca ggcctcgagc aggaggccgc ggccggcggc    900

gatgaagagg aggaggaaga ggaagaggag gaggaaggaa tctccgctct ggacggcgac    960

cagatggagc taggagagga gaacggggcc gcgggggcgg ccgactcggg cccgatggag   1020

gaggaggagg ccgcctcgga agacgagaac ggcgacgatc agggtttcca ggaaggggaa   1080

gatgagctcg gggacgaaga ggaaggcgcg ggcgacgaga acgggcacgg ggagcagcag   1140

cctcaaccgc cggcgacgca gcagcaacag ccccaacagc agcgcggggc cgccaaggag   1200

gccgcgggga agagcagcgg ccccacctcg ctgttcgcgg tgacggtggc gccgcccggg   1260

gcgaggcagg gccagcagca ggcgggaggt aagaagaagg cggaaggcgg cggaggcggc   1320

ggtcgccccg gggctccggc ggcgggggac ggcaaaacag aacagaaagg cggagataaa   1380

aagaggggtg ttaaaagacc acgagaagat catggccgtg gatattttga gtacattgaa   1440

gagaacaagt atagcagagc caaatctcct cagccacctg ttgaagaaga agatgaacac   1500

ttcgatgaca cagtggtttg tcttgatact tataattgtg atctacattt taaaatatca   1560

agagatcgtc tcagtgcttc ttcccttaca atggagagtt ttgcttttct ttgggctgga   1620

ggaagagcat cctatggtgt gtcaaaaggc aaagtgtgtt ttgagatgaa ggttacagag   1680

aagatcccag taaggcattt atatacaaaa gatattgaca tacatgaagt tcgtattggc   1740

tggtcactaa ctacaagtgg aatgttactt ggtgaagaag aattttctta tgggtattct   1800

ctaaaaggaa taaaaacatg caactgtgag actgaagatt atggagaaaa gtttgatgaa   1860

aatgatgtga ttacatgttt tgctaacttt gaaagtgatg aagtagaact ctcgtatgct   1920

aagaatggac aagatcttgg cgttgccttc aaaatcagta aggaagttct tgctggacgg   1980

ccactgttcc cgcatgttct ctgccacaac tgtgcagttg aatttaattt tggtcagaag   2040

gaaaagccat attttccaat acctgaagag tatactttca tccagaacgt ccccttagag   2100

gatcgagtta gaggaccaaa ggggcctgaa gagaagaaag attgtgaagt tgtgatgatg   2160

attggcttgc caggagctgg aaaaactacc tgggttacta aacatgcagc agaaaatcca   2220

gggaaatata acattcttgg cacaaatact attatggata agatgatggt ggcaggtttt   2280

aagaagcaaa tggcagatac tggaaaactg aacacactgt tgcagagagc cccccagtgt   2340

cttgggaaat ttattgagat tgctgcccga aagaagcgaa attttattct ggatcagaca   2400

aatgtgtctg ctgctgccca gaggagaaaa atgtgcctgt ttgcaggctt ccagcgaaaa   2460

gctgttgtag tttgcccaaa agatgaagac tataagcaaa gaacacagaa gaaagcagaa   2520

gtagagggga aagacctacc agaacatgcg gtcctcaaaa tgaaaggaaa ctttaccctc   2580

ccagaggtag ctgagtgctt tgatgaaata acctatgttg aacttcagaa ggaagaagcc   2640

caaaaactct tggagcaata taaggaagaa agcaaaaagg ctcttccacc agaaaagaaa   2700

cagaacactg gctcaaagaa aagcaataaa aataagagtg gcaagaacca gtttaacaga   2760

ggtggtggcc atagaggacg tggaggattc aatatgcgtg gtggaaattt cagaggagga   2820

ggcaacccct gggaatcgtg gcggatataa taggaggggc aacatgccac agagaggtgg   2880

tggcggtgga ggaagtggtg gaatcggcta tccataccct cgtgcccctg tttttcctgg   2940

ccgtggtagt tactcaaaca gagggaacta caacagaggt ggaatgccca acagagggaa   3000

ctacaaccag aacttcagag gacgaggaaa caatcgtggc tacaaaaatc aatctcaggg   3060

ctacaaccag tggcagcagg gtcaattctg gggtcagaag ccatggagtc agcattatca   3120

ccaaggatat tattgaatac ccaaataaaa cgaactgata catatttctc caaaaccttc   3180

acaagaagtc gactgttttc tttagtaggc taacttttta aacattccac aagaggaagt   3240

gcctgcgggt tcctttttta gaagctttgt gggttgattt tttttctttt cttttttgta   3300

catttttaat tgcagtttaa aagtgaatcg taagagaacc tcagcattgt gcacgataag   3360

agaatgtgtc agtatttcag ggttctacat tttatctgta aaatgtgact tttttttttt   3420

tttatcacaa cagaagtaaa atgttgcttt gtacctggtg tcttttatta agaatttact   3480

ccccccattt ctcacagaga ataacagtcg ggagtcattg tcacaatata atagaaatgt   3540

tagcaaccag attcatgtaa ggactaagtg gtcctcatga attgcattaa gactctgtac   3600

tgctcatatt acactccatc ctctctgtag tttgctgggt agtggagggg gtaagctaaa   3660

tcatagtttc tgacaataac tgggaaggtt ttttcttaaa ataacaatgg aattggtata   3720

attgggattg aaaactaaaa cttggaacta agatagagaa gatggagtgt atgtagaagg   3780

gctgttaaaa atgtaaaact tggttgcatt atttgtggag gctcaaactt gtgaaggtta   3840

ataccataat ttttccattt gttctgcatt ttgattctga aaagaaagct ggctttgccc   3900

atttcttatt aaaaaaactt gttgtaaatc c                                  3931


<210>  2113
<211>  731
<212>  PRT
<213>  Homo sapiens

<400>  2113

Met Ser Ser Ser Pro Val Asn Val Lys Lys Leu Lys Val Ser Glu Leu 
1               5                   10                  15


Lys Glu Glu Leu Lys Lys Arg Arg Leu Ser Asp Lys Gly Leu Lys Ala 
            20                  25                  30


Glu Leu Met Glu Arg Leu Gln Ala Ala Leu Asp Asp Glu Glu Ala Gly 
        35                  40                  45


Gly Arg Pro Ala Met Glu Pro Gly Asn Gly Ser Leu Asp Leu Gly Gly 
    50                  55                  60


Asp Ser Ala Gly Arg Ser Gly Ala Gly Leu Glu Gln Glu Ala Ala Ala 
65                  70                  75                  80


Gly Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ile 
                85                  90                  95


Ser Ala Leu Asp Gly Asp Gln Met Glu Leu Gly Glu Glu Asn Gly Ala 
            100                 105                 110


Ala Gly Ala Ala Asp Ser Gly Pro Met Glu Glu Glu Glu Ala Ala Ser 
        115                 120                 125


Glu Asp Glu Asn Gly Asp Asp Gln Gly Phe Gln Glu Gly Glu Asp Glu 
    130                 135                 140


Leu Gly Asp Glu Glu Glu Gly Ala Gly Asp Glu Asn Gly His Gly Glu 
145                 150                 155                 160


Gln Gln Pro Gln Pro Pro Ala Thr Gln Gln Gln Gln Pro Gln Gln Gln 
                165                 170                 175


Arg Gly Ala Ala Lys Glu Ala Ala Gly Lys Ser Ser Gly Pro Thr Ser 
            180                 185                 190


Leu Phe Ala Val Thr Val Ala Pro Pro Gly Ala Arg Gln Gly Gln Gln 
        195                 200                 205


Gln Ala Gly Gly Lys Lys Lys Ala Glu Gly Gly Gly Gly Gly Gly Arg 
    210                 215                 220


Pro Gly Ala Pro Ala Ala Gly Asp Gly Lys Thr Glu Gln Lys Gly Gly 
225                 230                 235                 240


Asp Lys Lys Arg Gly Val Lys Arg Pro Arg Glu Asp His Gly Arg Gly 
                245                 250                 255


Tyr Phe Glu Tyr Ile Glu Glu Asn Lys Tyr Ser Arg Ala Lys Ser Pro 
            260                 265                 270


Gln Pro Pro Val Glu Glu Glu Asp Glu His Phe Asp Asp Thr Val Val 
        275                 280                 285


Cys Leu Asp Thr Tyr Asn Cys Asp Leu His Phe Lys Ile Ser Arg Asp 
    290                 295                 300


Arg Leu Ser Ala Ser Ser Leu Thr Met Glu Ser Phe Ala Phe Leu Trp 
305                 310                 315                 320


Ala Gly Gly Arg Ala Ser Tyr Gly Val Ser Lys Gly Lys Val Cys Phe 
                325                 330                 335


Glu Met Lys Val Thr Glu Lys Ile Pro Val Arg His Leu Tyr Thr Lys 
            340                 345                 350


Asp Ile Asp Ile His Glu Val Arg Ile Gly Trp Ser Leu Thr Thr Ser 
        355                 360                 365


Gly Met Leu Leu Gly Glu Glu Glu Phe Ser Tyr Gly Tyr Ser Leu Lys 
    370                 375                 380


Gly Ile Lys Thr Cys Asn Cys Glu Thr Glu Asp Tyr Gly Glu Lys Phe 
385                 390                 395                 400


Asp Glu Asn Asp Val Ile Thr Cys Phe Ala Asn Phe Glu Ser Asp Glu 
                405                 410                 415


Val Glu Leu Ser Tyr Ala Lys Asn Gly Gln Asp Leu Gly Val Ala Phe 
            420                 425                 430


Lys Ile Ser Lys Glu Val Leu Ala Gly Arg Pro Leu Phe Pro His Val 
        435                 440                 445


Leu Cys His Asn Cys Ala Val Glu Phe Asn Phe Gly Gln Lys Glu Lys 
    450                 455                 460


Pro Tyr Phe Pro Ile Pro Glu Glu Tyr Thr Phe Ile Gln Asn Val Pro 
465                 470                 475                 480


Leu Glu Asp Arg Val Arg Gly Pro Lys Gly Pro Glu Glu Lys Lys Asp 
                485                 490                 495


Cys Glu Val Val Met Met Ile Gly Leu Pro Gly Ala Gly Lys Thr Thr 
            500                 505                 510


Trp Val Thr Lys His Ala Ala Glu Asn Pro Gly Lys Tyr Asn Ile Leu 
        515                 520                 525


Gly Thr Asn Thr Ile Met Asp Lys Met Met Val Ala Gly Phe Lys Lys 
    530                 535                 540


Gln Met Ala Asp Thr Gly Lys Leu Asn Thr Leu Leu Gln Arg Ala Pro 
545                 550                 555                 560


Gln Cys Leu Gly Lys Phe Ile Glu Ile Ala Ala Arg Lys Lys Arg Asn 
                565                 570                 575


Phe Ile Leu Asp Gln Thr Asn Val Ser Ala Ala Ala Gln Arg Arg Lys 
            580                 585                 590


Met Cys Leu Phe Ala Gly Phe Gln Arg Lys Ala Val Val Val Cys Pro 
        595                 600                 605


Lys Asp Glu Asp Tyr Lys Gln Arg Thr Gln Lys Lys Ala Glu Val Glu 
    610                 615                 620


Gly Lys Asp Leu Pro Glu His Ala Val Leu Lys Met Lys Gly Asn Phe 
625                 630                 635                 640


Thr Leu Pro Glu Val Ala Glu Cys Phe Asp Glu Ile Thr Tyr Val Glu 
                645                 650                 655


Leu Gln Lys Glu Glu Ala Gln Lys Leu Leu Glu Gln Tyr Lys Glu Glu 
            660                 665                 670


Ser Lys Lys Ala Leu Pro Pro Glu Lys Lys Gln Asn Thr Gly Ser Lys 
        675                 680                 685


Lys Ser Asn Lys Asn Lys Ser Gly Lys Asn Gln Phe Asn Arg Gly Gly 
    690                 695                 700


Gly His Arg Gly Arg Gly Gly Phe Asn Met Arg Gly Gly Asn Phe Arg 
705                 710                 715                 720


Gly Gly Gly Asn Pro Trp Glu Ser Trp Arg Ile 
                725                 730


<210>  2114
<211>  1660
<212>  DNA
<213>  Homo sapiens

<400>  2114
acgaagagct ggagaaacac ataagaaggc agatctaaga tggaagaaaa ggcggattcg     60

ggttgaaacg ccaagttgag gactgaagaa agcatttgga taaagcagcc tccaagctgg    120

gaaggagaaa agccaaacga gtatagccac caaagaccca gaaaggccaa tatatcatgc    180

agtgagtcgg ttgaactgaa aggcggtttc cttttcctcc atttgctcag tcccaattgg    240

aagcgcactg cgcggcctcc accgcgctct cggcccgggt tcggcgtggg ggcggggagg    300

taagtacggt aatgggcggg gccgagcgcg ggcgcgctcc ggctttcctc ctgcgcagtg    360

ctcccgtcag cgcagggggc ggggcgccta tattacgtgc gcggcgccgc tcctgcgaga    420

ggacgttgcg tgctcgctcg cgccaggcga gtctccgcgt ctccctcgcg aactcggtga    480

aaggaattgg cgccgttcga caccaggcgg atccgctctg cagcacgaac ccatctccag    540

ccgcagccgc agcccccctg ggaatcgtgg cggatataat aggaggggca acatgccaca    600

gagaggtggt ggcggtggag gaagtggtgg aatcggctat ccataccctc gtgcccctgt    660

ttttcctggc cgtggtagtt actcaaacag agggaactac aacagaggtg gaatgcccaa    720

cagagggaac tacaaccaga acttcagagg acgaggaaac aatcgtggct acaaaaatca    780

atctcagggc tacaaccagt ggcagcaggg tcaattctgg ggtcagaagc catggagtca    840

gcattatcac caaggatatt attgaatacc caaataaaac gaactgatac atatttctcc    900

aaaaccttca caagaagtcg actgttttct ttagtaggct aactttttaa acattccaca    960

agaggaagtg cctgcgggtt ccttttttag aagctttgtg ggttgatttt ttttcttttc   1020

ttttttgtac atttttaatt gcagtttaaa agtgaatcgt aagagaacct cagcattgtg   1080

cacgataaga gaatgtgtca gtatttcagg gttctacatt ttatctgtaa aatgtgactt   1140

tttttttttt ttatcacaac agaagtaaaa tgttgctttg tacctggtgt cttttattaa   1200

gaatttactc cccccatttc tcacagagaa taacagtcgg gagtcattgt cacaatataa   1260

tagaaatgtt agcaaccaga ttcatgtaag gactaagtgg tcctcatgaa ttgcattaag   1320

actctgtact gctcatatta cactccatcc tctctgtagt ttgctgggta gtggaggggg   1380

taagctaaat catagtttct gacaataact gggaaggttt tttcttaaaa taacaatgga   1440

attggtataa ttgggattga aaactaaaac ttggaactaa gatagagaag atggagtgta   1500

tgtagaaggg ctgttaaaaa tgtaaaactt ggttgcatta tttgtggagg ctcaaacttg   1560

tgaaggttaa taccataatt tttccatttg ttctgcattt tgattctgaa aagaaagctg   1620

gctttgccca tttcttatta aaaaaacttg ttgtaaatcc                         1660


<210>  2115
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  2115

Met Gly Gly Ala Glu Arg Gly Arg Ala Pro Ala Phe Leu Leu Arg Ser 
1               5                   10                  15


Ala Pro Val Ser Ala Gly Gly Gly Ala Pro Ile Leu Arg Ala Arg Arg 
            20                  25                  30


Arg Ser Cys Glu Arg Thr Leu Arg Ala Arg Ser Arg Gln Ala Ser Leu 
        35                  40                  45


Arg Val Ser Leu Ala Asn Ser Val Lys Gly Ile Gly Ala Val Arg His 
    50                  55                  60


Gln Ala Asp Pro Leu Cys Ser Thr Asn Pro Ser Pro Ala Ala Ala Ala 
65                  70                  75                  80


Ala Pro Leu Gly Ile Val Ala Asp Ile Ile Gly Gly Ala Thr Cys His 
                85                  90                  95


Arg Glu Val Val Ala Val Glu Glu Val Val Glu Ser Ala Ile His Thr 
            100                 105                 110


Leu Val Pro Leu Phe Phe Leu Ala Val Val Val Thr Gln Thr Glu Gly 
        115                 120                 125


Thr Thr Thr Glu Val Glu Cys Pro Thr Glu Gly Thr Thr Thr Arg Thr 
    130                 135                 140


Ser Glu Asp Glu Glu Thr Ile Val Ala Thr Lys Ile Asn Leu Arg Ala 
145                 150                 155                 160


Thr Thr Ser Gly Ser Arg Val Asn Ser Gly Val Arg Ser His Gly Val 
                165                 170                 175


Ser Ile Ile Thr Lys Asp Ile Ile Glu Tyr Pro Asn Lys Thr Asn 
            180                 185                 190


<210>  2116
<211>  3008
<212>  DNA
<213>  Homo sapiens

<400>  2116
agagtgtcaa tgtaaaactc tttcttactg gaatatcctt tacagaaggt tgagatagtc     60

atctgagcct ttttaaaaga aaaaactgca ggtgaaaaag gagttagttg atgtgaaagt    120

tttagtgaaa ttctgggttg tataaataag ttgctaggaa ttggcaaggt agtgaagtgg    180

tgactcacac aggtaatgta attgttagat tttttagcaa atcaggaata tgtcaatata    240

agtacaatgt tgaattcaaa caatctgttg aattaaattc tgttgattag aataactcta    300

atttaagaaa aattccaaac tgtagattta tttttctctg atcagtaaaa agaaaatgag    360

ttccagcttg actttagctg ttcaagtgag aagtctgagg aagtgcatgt taatgagcca    420

gtgacccata ggtagctggg ttaaagacac tttggatttg gataatccgg gaagcaatta    480

atccctaatt gttgaacagg cagtcctggg taaagaggac ctaaaatgct gcactattaa    540

cagcattaga cggccaggtt tgtacttcat agttttaggc tgtcttcttc acaagtttta    600

gaaaaagaat ttaggagcta gagccctggt gcaggatcaa cagcagctca tactcctatt    660

ttaaaataat ttggtcgtgg cctcccttca gttttaatgt ggcactggta aatctacctg    720

gttctggcat gcttcacttt gatttcctgc tatcctctac tgcttgcctc taaatcaagg    780

taaagagcag agcaggtatg tattaatgtc acattgtctt gattatttta aatacttaaa    840

atatacatgt taaaccttgg tattagtttc acaggcagtt tacttttcag tacataattt    900

aacaggagtg acttggtggg agtggggctt taaactgaaa attggaacaa cagcatgatg    960

tggagaaaag ttgtgcagca ttaagaagta catgcaaaaa ttaagtaacc aagttttgtc   1020

tacatagcag atatgtttac attggatgtc aaaagtaaca cagtatttga tataattaca   1080

gataattgtg atctacattt taaaatatca agagatcgtc tcagtgcttc ttcccttaca   1140

atggagagtt ttgcttttct ttgggctgga ggaagagcat cctatggtgt gtcaaaaggc   1200

aaagtgtgtt ttgagatgaa ggttacagag aagatcccag taaggcattt atatacaaaa   1260

gatattgaca tacatgaagt tcgtattggc tggtcactaa ctacaagtgg aatgttactt   1320

ggtgaagaag aattttctta tgggtattct ctaaaaggaa taaaaacatg caactgtgag   1380

actgaagatt atggagaaaa gtttgatgaa aatgatgtga ttacatgttt tgctaacttt   1440

gaaagtgatg aagtagaact ctcgtatgct aagaatggac aagatcttgg cgttgccttc   1500

aaaatcagta aggaagttct tgctggacgg ccactgttcc cgcatgttct ctgccacaac   1560

tgtgcagttg aatttaattt tggtcagaag gaaaagccat attttccaat acctgaagag   1620

tatactttca tccagaacgt ccccttagag gatcgagtta gaggaccaaa ggggcctgaa   1680

gagaagaaag attgtgaagt tgtgatgatg attggcttgc caggagctgg aaaaactacc   1740

tgggttacta aacatgcagc agaaaatcca gggaaatata acattcttgg cacaaatact   1800

attatggata agatgatggt ggcaggtttt aagaagcaaa tggcagatac tggaaaactg   1860

aacacactgt tgcagagagc cccccagtgt cttgggaaat ttattgagat tgctgcccga   1920

aagaagcgaa attttattct ggatcagaca aatgtgtctg ctgctgccca gaggagaaaa   1980

atgtgcctgt ttgcaggctt ccagcgaaaa gctgttgtag tttgcccaaa agatgaagac   2040

tataagcaaa gaacacagaa gaaagcagaa gtagagggga aagacctacc agaacatgcg   2100

gtcctcaaaa tgaaaggaaa ctttaccctc ccagaggtag ctgagtgctt tgatgaaata   2160

acctatgttg aacttcagaa ggaagaagcc caaaaactct tggagcaata taaggaagaa   2220

agcaaaaagg ctcttccacc agaaaagaaa cagaacactg gctcaaagaa aagcaataaa   2280

aataagagtg gcaagaacca gtttaacaga ggtggtggcc atagaggacg tggaggattc   2340

aatatgcgtg gtggaaattt cagaggagga ggcaacccct gggaatcgtg gcggatataa   2400

taggaggggc aacatgccac agagaggtgg tggcggtgga ggaagtggtg gaatcggcta   2460

tccataccct cgtgcccctg tttttcctgg ccgtggtagt tactcaaaca gagggaacta   2520

caacagaggt ggaatgccca acagagggaa ctacaaccag aacttcagag gacgaggaaa   2580

caatcgtggc tacaaaaatc aatctcaggg ctacaaccag tggcagcagg gtcaattctg   2640

gggtcagaag ccatggagtc agcattatca ccaaggatat tattgaatac ccaaataaaa   2700

cgaactgata catatttctc caaaaccttc acaagaagtc gactgttttc tttagtaggc   2760

taacttttta aacattccac aagaggaagt gcctgcgggt tcctttttta gaagctttgt   2820

gggttgattt tttttctttt cttttttgta catttttaat tgcagtttaa aagtgaatcg   2880

taagagaacc tcagcattgt gcacgataag agaatgtgtc agtatttcag ggttctacat   2940

tttatctgta aaatgtgact tttttttttt tttatcacaa cagaagtaaa atgttgcttt   3000

gtacctgg                                                            3008


<210>  2117
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  2117

Met Phe Thr Leu Asp Val Lys Ser Asn Thr Val Phe Asp Ile Ile Thr 
1               5                   10                  15


Asp Asn Cys Asp Leu His Phe Lys Ile Ser Arg Asp Arg Leu Ser Ala 
            20                  25                  30


Ser Ser Leu Thr Met Glu Ser Phe Ala Phe Leu Trp Ala Gly Gly Arg 
        35                  40                  45


Ala Ser Tyr Gly Val Ser Lys Gly Lys Val Cys Phe Glu Met Lys Val 
    50                  55                  60


Thr Glu Lys Ile Pro Val Arg His Leu Tyr Thr Lys Asp Ile Asp Ile 
65                  70                  75                  80


His Glu Val Arg Ile Gly Trp Ser Leu Thr Thr Ser Gly Met Leu Leu 
                85                  90                  95


Gly Glu Glu Glu Phe Ser Tyr Gly Tyr Ser Leu Lys Gly Ile Lys Thr 
            100                 105                 110


Cys Asn Cys Glu Thr Glu Asp Tyr Gly Glu Lys Phe Asp Glu Asn Asp 
        115                 120                 125


Val Ile Thr Cys Phe Ala Asn Phe Glu Ser Asp Glu Val Glu Leu Ser 
    130                 135                 140


Tyr Ala Lys Asn Gly Gln Asp Leu Gly Val Ala Phe Lys Ile Ser Lys 
145                 150                 155                 160


Glu Val Leu Ala Gly Arg Pro Leu Phe Pro His Val Leu Cys His Asn 
                165                 170                 175


Cys Ala Val Glu Phe Asn Phe Gly Gln Lys Glu Lys Pro Tyr Phe Pro 
            180                 185                 190


Ile Pro Glu Glu Tyr Thr Phe Ile Gln Asn Val Pro Leu Glu Asp Arg 
        195                 200                 205


Val Arg Gly Pro Lys Gly Pro Glu Glu Lys Lys Asp Cys Glu Val Val 
    210                 215                 220


Met Met Ile Gly Leu Pro Gly Ala Gly Lys Thr Thr Trp Val Thr Lys 
225                 230                 235                 240


His Ala Ala Glu Asn Pro Gly Lys Tyr Asn Ile Leu Gly Thr Asn Thr 
                245                 250                 255


Ile Met Asp Lys Met Met Val Ala Gly Phe Lys Lys Gln Met Ala Asp 
            260                 265                 270


Thr Gly Lys Leu Asn Thr Leu Leu Gln Arg Ala Pro Gln Cys Leu Gly 
        275                 280                 285


Lys Phe Ile Glu Ile Ala Ala Arg Lys Lys Arg Asn Phe Ile Leu Asp 
    290                 295                 300


Gln Thr Asn Val Ser Ala Ala Ala Gln Arg Arg Lys Met Cys Leu Phe 
305                 310                 315                 320


Ala Gly Phe Gln Arg Lys Ala Val Val Val Cys Pro Lys Asp Glu Asp 
                325                 330                 335


Tyr Lys Gln Arg Thr Gln Lys Lys Ala Glu Val Glu Gly Lys Asp Leu 
            340                 345                 350


Pro Glu His Ala Val Leu Lys Met Lys Gly Asn Phe Thr Leu Pro Glu 
        355                 360                 365


Val Ala Glu Cys Phe Asp Glu Ile Thr Tyr Val Glu Leu Gln Lys Glu 
    370                 375                 380


Glu Ala Gln Lys Leu Leu Glu Gln Tyr Lys Glu Glu Ser Lys Lys Ala 
385                 390                 395                 400


Leu Pro Pro Glu Lys Lys Gln Asn Thr Gly Ser Lys Lys Ser Asn Lys 
                405                 410                 415


Asn Lys Ser Gly Lys Asn Gln Phe Asn Arg Gly Gly Gly His Arg Gly 
            420                 425                 430


Arg Gly Gly Phe Asn Met Arg Gly Gly Asn Phe Arg Gly Gly Gly Asn 
        435                 440                 445


Pro Trp Glu Ser Trp Arg Ile 
    450                 455


<210>  2118
<211>  3401
<212>  DNA
<213>  Homo sapiens

<400>  2118
acgaagagct ggagaaacac ataagaaggc agatctaaga tggaagaaaa ggcggattcg     60

ggttgaaacg ccaagttgag gactgaagaa agcatttgga taaagcagcc tccaagctgg    120

gaaggagaaa agccaaacga gtatagccac caaagaccca gaaaggccaa tatatcatgc    180

agtgagtcgg ttgaactgaa aggcggtttc cttttcctcc atttgctcag tcccaattgg    240

aagcgcactg cgcggcctcc accgcgctct cggcccgggt tcggcgtggg ggcggggagg    300

taagtacggt aatgggcggg gccgagcgcg ggcgcgctcc ggctttcctc ctgcgcagtg    360

ctcccgtcag cgcagggggc ggggcgccta tattacgtgc gcggcgccgc tcctgcgaga    420

ggacgttgcg tgctcgctcg cgccaggcga gtctccgcgt ctccctcgcg aactcggtga    480

aaggaattgg cgccgttcga caccaggcgg atccgctctg cagcacgaac ccatctccag    540

ccgcagccgc agccgccgcc cgggccgagg agcagccgca gcagccgcca ccagtggccg    600

agtgagcgga gccgagtttg aggcagcgcc tagcggtgaa tcggggccct caccatgagt    660

tcctcgcctg ttaatgtaaa aaagctgaag gtgtcggagc tgaaagagga gctcaagaag    720

cgacgccttt ctgacaaggg tctcaaggcc gagctcatgg agcgactcca ggctgcgctg    780

gacgacgagg aggccggggg ccgccccgcc atggagcccg ggaacggcag cctagacctg    840

ggcggggatt ccgctgggcg ctcgggagca ggcctcgagc aggaggccgc ggccggcggc    900

gatgaagagg aggaggaaga ggaagaggag gaggaaggaa tctccgctct ggacggcgac    960

cagatggagc taggagagga gaacggggcc gcgggggcgg ccgactcggg cccgatggag   1020

gaggaggagg ccgcctcgga agacgagaac ggcgacgatc agggtttcca ggaaggggaa   1080

gatgagctcg gggacgaaga ggaaggcgcg ggcgacgaga acgggcacgg ggagcagcag   1140

cctcaaccgc cggcgacgca gcagcaacag ccccaacagc agcgcggggc cgccaaggag   1200

gccgcgggga agagcagcgg ccccacctcg ctgttcgcgg tgacggtggc gccgcccggg   1260

gcgaggcagg gccagcagca ggcgggaggg gacggcaaaa cagaacagaa aggcggagat   1320

aaaaagaggg gtgttaaaag accacgagaa gatcatggcc gtggatattt tgagtacatt   1380

gaagagaaca agtatagcag agccaaatct cctcagccac ctgttgaaga agaagatgaa   1440

cacttcgatg acacagtggt ttgtcttgat acttataatt gtgatctaca ttttaaaata   1500

tcaagagatc gtctcagtgc ttcttccctt acaatggaga gttttgcttt tctttgggct   1560

ggaggaagag catcctatgg tgtgtcaaaa ggcaaagtgt gttttgagat gaaggttaca   1620

gagaagatcc cagtaaggca tttatataca aaagatattg acatacatga agttcgtatt   1680

ggctggtcac taactacaag tggaatgtta cttggtgaag aagaattttc ttatgggtat   1740

tctctaaaag gaataaaaac atgcaactgt gagactgaag attatggaga aaagtttgat   1800

gaaaatgatg tgattacatg ttttgctaac tttgaaagtg atgaagtaga actctcgtat   1860

gctaagaatg gacaagatct tggcgttgcc ttcaaaatca gtaaggaagt tcttgctgga   1920

cggccactgt tcccgcatgt tctctgccac aactgtgcag ttgaatttaa ttttggtcag   1980

aaggaaaagc catattttcc aatacctgaa gagtatactt tcatccagaa cgtcccctta   2040

gaggatcgag ttagaggacc aaaggggcct gaagagaaga aagattgtga agttgtgatg   2100

atgattggct tgccaggagc tggaaaaact acctgggtta ctaaacatgc agcagaaaat   2160

ccagggaaat ataacattct tggcacaaat actattatgg ataagatgat ggtggcaggt   2220

tttaagaagc aaatggcaga tactggaaaa ctgaacacac tgttgcagag agccccccag   2280

tgtcttggga aatttattga gattgctgcc cgaaagaagc gaaattttat tctggatcag   2340

acaaatgtgt ctgctgctgc ccagaggaga aaaatgtgcc tgtttgcagg cttccagcga   2400

aaagctgttg tagtttgccc aaaagatgaa gactataagc aaagaacaca gaagaaagca   2460

gaagtagagg ggaaagacct accagaacat gcggtcctca aaatgaaagg aaactttacc   2520

ctcccagagg tagctgagtg ctttgatgaa ataacctatg ttgaacttca gaaggaagaa   2580

gcccaaaaac tcttggagca atataaggaa gaaagcaaaa aggctcttcc accagaaaag   2640

aaacagaaca ctggctcaaa gaaaagcaat aaaaataaga gtggcaagaa ccagtttaac   2700

agaggtggtg gccatagagg acgtggagga ttcaatatgc gtggtggaaa tttcagagga   2760

ggaggcaacc cctgggaatc gtggcggata taataggagg ggcaacatgc cacagagagg   2820

tggtggcggt ggaggaagtg gtggaatcgg ctatccatac cctcgtgccc ctgtttttcc   2880

tggccgtggt agttactcaa acagagggaa ctacaacaga ggtggaatgc ccaacagagg   2940

gaactacaac cagaacttca gaggacgagg aaacaatcgt ggctacaaaa atcaatctca   3000

gggctacaac cagtggcagc agggtcaatt ctggggtcag aagccatgga gtcagcatta   3060

tcaccaagga tattattgaa tacccaaata aaacgaactg atacatattt ctccaaaacc   3120

ttcacaagaa gtcgactgtt ttctttagta ggctaacttt ttaaacattc cacaagagga   3180

agtgcctgcg ggttcctttt ttagaagctt tgtgggttga ttttttttct tttctttttt   3240

gtacattttt aattgcagtt taaaagtgaa tcgtaagaga acctcagcat tgtgcacgat   3300

aagagaatgt gtcagtattt cagggttcta cattttatct gtaaaatgtg actttttttt   3360

ttttttatca caacagaagt aaaatgttgc tttgtacctg g                       3401


<210>  2119
<211>  712
<212>  PRT
<213>  Homo sapiens

<400>  2119

Met Ser Ser Ser Pro Val Asn Val Lys Lys Leu Lys Val Ser Glu Leu 
1               5                   10                  15


Lys Glu Glu Leu Lys Lys Arg Arg Leu Ser Asp Lys Gly Leu Lys Ala 
            20                  25                  30


Glu Leu Met Glu Arg Leu Gln Ala Ala Leu Asp Asp Glu Glu Ala Gly 
        35                  40                  45


Gly Arg Pro Ala Met Glu Pro Gly Asn Gly Ser Leu Asp Leu Gly Gly 
    50                  55                  60


Asp Ser Ala Gly Arg Ser Gly Ala Gly Leu Glu Gln Glu Ala Ala Ala 
65                  70                  75                  80


Gly Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ile 
                85                  90                  95


Ser Ala Leu Asp Gly Asp Gln Met Glu Leu Gly Glu Glu Asn Gly Ala 
            100                 105                 110


Ala Gly Ala Ala Asp Ser Gly Pro Met Glu Glu Glu Glu Ala Ala Ser 
        115                 120                 125


Glu Asp Glu Asn Gly Asp Asp Gln Gly Phe Gln Glu Gly Glu Asp Glu 
    130                 135                 140


Leu Gly Asp Glu Glu Glu Gly Ala Gly Asp Glu Asn Gly His Gly Glu 
145                 150                 155                 160


Gln Gln Pro Gln Pro Pro Ala Thr Gln Gln Gln Gln Pro Gln Gln Gln 
                165                 170                 175


Arg Gly Ala Ala Lys Glu Ala Ala Gly Lys Ser Ser Gly Pro Thr Ser 
            180                 185                 190


Leu Phe Ala Val Thr Val Ala Pro Pro Gly Ala Arg Gln Gly Gln Gln 
        195                 200                 205


Gln Ala Gly Gly Asp Gly Lys Thr Glu Gln Lys Gly Gly Asp Lys Lys 
    210                 215                 220


Arg Gly Val Lys Arg Pro Arg Glu Asp His Gly Arg Gly Tyr Phe Glu 
225                 230                 235                 240


Tyr Ile Glu Glu Asn Lys Tyr Ser Arg Ala Lys Ser Pro Gln Pro Pro 
                245                 250                 255


Val Glu Glu Glu Asp Glu His Phe Asp Asp Thr Val Val Cys Leu Asp 
            260                 265                 270


Thr Tyr Asn Cys Asp Leu His Phe Lys Ile Ser Arg Asp Arg Leu Ser 
        275                 280                 285


Ala Ser Ser Leu Thr Met Glu Ser Phe Ala Phe Leu Trp Ala Gly Gly 
    290                 295                 300


Arg Ala Ser Tyr Gly Val Ser Lys Gly Lys Val Cys Phe Glu Met Lys 
305                 310                 315                 320


Val Thr Glu Lys Ile Pro Val Arg His Leu Tyr Thr Lys Asp Ile Asp 
                325                 330                 335


Ile His Glu Val Arg Ile Gly Trp Ser Leu Thr Thr Ser Gly Met Leu 
            340                 345                 350


Leu Gly Glu Glu Glu Phe Ser Tyr Gly Tyr Ser Leu Lys Gly Ile Lys 
        355                 360                 365


Thr Cys Asn Cys Glu Thr Glu Asp Tyr Gly Glu Lys Phe Asp Glu Asn 
    370                 375                 380


Asp Val Ile Thr Cys Phe Ala Asn Phe Glu Ser Asp Glu Val Glu Leu 
385                 390                 395                 400


Ser Tyr Ala Lys Asn Gly Gln Asp Leu Gly Val Ala Phe Lys Ile Ser 
                405                 410                 415


Lys Glu Val Leu Ala Gly Arg Pro Leu Phe Pro His Val Leu Cys His 
            420                 425                 430


Asn Cys Ala Val Glu Phe Asn Phe Gly Gln Lys Glu Lys Pro Tyr Phe 
        435                 440                 445


Pro Ile Pro Glu Glu Tyr Thr Phe Ile Gln Asn Val Pro Leu Glu Asp 
    450                 455                 460


Arg Val Arg Gly Pro Lys Gly Pro Glu Glu Lys Lys Asp Cys Glu Val 
465                 470                 475                 480


Val Met Met Ile Gly Leu Pro Gly Ala Gly Lys Thr Thr Trp Val Thr 
                485                 490                 495


Lys His Ala Ala Glu Asn Pro Gly Lys Tyr Asn Ile Leu Gly Thr Asn 
            500                 505                 510


Thr Ile Met Asp Lys Met Met Val Ala Gly Phe Lys Lys Gln Met Ala 
        515                 520                 525


Asp Thr Gly Lys Leu Asn Thr Leu Leu Gln Arg Ala Pro Gln Cys Leu 
    530                 535                 540


Gly Lys Phe Ile Glu Ile Ala Ala Arg Lys Lys Arg Asn Phe Ile Leu 
545                 550                 555                 560


Asp Gln Thr Asn Val Ser Ala Ala Ala Gln Arg Arg Lys Met Cys Leu 
                565                 570                 575


Phe Ala Gly Phe Gln Arg Lys Ala Val Val Val Cys Pro Lys Asp Glu 
            580                 585                 590


Asp Tyr Lys Gln Arg Thr Gln Lys Lys Ala Glu Val Glu Gly Lys Asp 
        595                 600                 605


Leu Pro Glu His Ala Val Leu Lys Met Lys Gly Asn Phe Thr Leu Pro 
    610                 615                 620


Glu Val Ala Glu Cys Phe Asp Glu Ile Thr Tyr Val Glu Leu Gln Lys 
625                 630                 635                 640


Glu Glu Ala Gln Lys Leu Leu Glu Gln Tyr Lys Glu Glu Ser Lys Lys 
                645                 650                 655


Ala Leu Pro Pro Glu Lys Lys Gln Asn Thr Gly Ser Lys Lys Ser Asn 
            660                 665                 670


Lys Asn Lys Ser Gly Lys Asn Gln Phe Asn Arg Gly Gly Gly His Arg 
        675                 680                 685


Gly Arg Gly Gly Phe Asn Met Arg Gly Gly Asn Phe Arg Gly Gly Gly 
    690                 695                 700


Asn Pro Trp Glu Ser Trp Arg Ile 
705                 710


<210>  2120
<211>  1187
<212>  DNA
<213>  Homo sapiens

<400>  2120
acgaagagct ggagaaacac ataagaaggc agatctaaga tggaagaaaa ggcggattcg     60

ggttgaaacg ccaagttgag gactgaagaa agcatttgga taaagcagcc tccaagctgg    120

gaaggagaaa agccaaacga gtatagccac caaagaccca gaaaggccaa tatatcatgc    180

agtgagtcgg ttgaactgaa aggcggtttc cttttcctcc atttgctcag tcccaattgg    240

aagcgcactg cgcggcctcc accgcgctct cggcccgggt tcggcgtggg ggcggggagg    300

taagtacggt aatgggcggg gccgagcgcg ggcgcgctcc ggctttcctc ctgcgcagtg    360

ctcccgtcag cgcagggggc ggggcgccta tattacgtgc gcggcgccgc tcctgcgaga    420

ggacgttgcg tgctcgctcg cgccaggcga gtctccgcgt ctccctcgcg aactcggtga    480

aaggaattgg cgccgttcga caccaggcgg atccgctctg cagcacgaac ccatctccag    540

ccgcagccgc agcccccctg ggaatcgtgg cggatataat aggaggggca acatgccaca    600

gagaggtggt ggcggtggag gaagtggtgg aatcggctat ccataccctc gtgcccctgt    660

ttttcctggc cgtggtagtt actcaaacag agggaactac aacagaggtg gaatgcccaa    720

cagagggaac tacaaccaga acttcagagg acgaggaaac aatcgtggct acaaaaatca    780

atctcagggc tacaaccagt ggcagcaggg tcaattctgg ggtcagaagc catggagtca    840

gcattatcac caaggatatt attgaatacc caaataaaac gaactgatac atatttctcc    900

aaaaccttca caagaagtcg actgttttct ttagtaggct aactttttaa acattccaca    960

agaggaagtg cctgcgggtt ccttttttag aagctttgtg ggttgatttt ttttcttttc   1020

ttttttgtac atttttaatt gcagtttaaa agtgaatcgt aagagaacct cagcattgtg   1080

cacgataaga gaatgtgtca gtatttcagg gttctacatt ttatctgtaa aatgtgactt   1140

tttttttttt ttatcacaac agaagtaaaa tgttgctttg tacctgg                 1187


<210>  2121
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  2121

Met Gly Gly Ala Glu Arg Gly Arg Ala Pro Ala Phe Leu Leu Arg Ser 
1               5                   10                  15


Ala Pro Val Ser Ala Gly Gly Gly Ala Pro Ile Leu Arg Ala Arg Arg 
            20                  25                  30


Arg Ser Cys Glu Arg Thr Leu Arg Ala Arg Ser Arg Gln Ala Ser Leu 
        35                  40                  45


Arg Val Ser Leu Ala Asn Ser Val Lys Gly Ile Gly Ala Val Arg His 
    50                  55                  60


Gln Ala Asp Pro Leu Cys Ser Thr Asn Pro Ser Pro Ala Ala Ala Ala 
65                  70                  75                  80


Ala Pro Leu Gly Ile Val Ala Asp Ile Ile Gly Gly Ala Thr Cys His 
                85                  90                  95


Arg Glu Val Val Ala Val Glu Glu Val Val Glu Ser Ala Ile His Thr 
            100                 105                 110


Leu Val Pro Leu Phe Phe Leu Ala Val Val Val Thr Gln Thr Glu Gly 
        115                 120                 125


Thr Thr Thr Glu Val Glu Cys Pro Thr Glu Gly Thr Thr Thr Arg Thr 
    130                 135                 140


Ser Glu Asp Glu Glu Thr Ile Val Ala Thr Lys Ile Asn Leu Arg Ala 
145                 150                 155                 160


Thr Thr Ser Gly Ser Arg Val Asn Ser Gly Val Arg Ser His Gly Val 
                165                 170                 175


Ser Ile Ile Thr Lys Asp Ile Ile Glu Tyr Pro Asn Lys Thr Asn 
            180                 185                 190


<210>  2122
<211>  3123
<212>  DNA
<213>  Homo sapiens

<400>  2122
acgaagagct ggagaaacac ataagaaggc agatctaaga tggaagaaaa ggcggattcg     60

ggttgaaacg ccaagttgag gactgaagaa agcatttgga taaagcagcc tccaagctgg    120

gaaggagaaa agccaaacga gtatagccac caaagaccca gaaaggccaa tatatcatgc    180

agtgagtcgg ttgaactgaa aggcggtttc cttttcctcc atttgctcag tcccaattgg    240

aagcgcactg cgcggcctcc accgcgctct cggcccgggt tcggcgtggg ggcggggagg    300

taagtacggt aatgggcggg gccgagcgcg ggcgcgctcc ggctttcctc ctgcgcagtg    360

ctcccgtcag cgcagggggc ggggcgccta tattacgtgc gcggcgccgc tcctgcgaga    420

ggacgttgcg tgctcgctcg cgccaggcga gtctccgcgt ctccctcgcg aactcggtga    480

aaggaattgg cgccgttcga caccaggcgg atccgctctg cagcacgaac ccatctccag    540

ccgcagccgc agccgccgcc cgggccgagg agcagccgca gcagccgcca ccagtggccg    600

agtgagcgga gccgagtttg aggcagcgcc tagcggtgaa tcggggccct caccatgagt    660

tcctcgcctg ttaatgtaaa aaagctgaag gtgtcggagc tgaaagagga gctcaagaag    720

cgacgccttt ctgacaaggg tctcaaggcc gagctcatgg agcgactcca ggctgcgctg    780

gacgacgagg aggccggggg ccgccccgcc atggagcccg ggaacggcag cctagacctg    840

ggcggggatt ccgctgggcg ctcgggagca ggcctcgagc aggaggccgc ggccggcggc    900

gatgaagagg aggaggaaga ggaagaggag gaggaaggaa tctccgctct ggacggcgac    960

cagatggagc taggagagga gaacggggcc gcgggggcgg ccgactcggg cccgatggag   1020

gaggaggagg ccgcctcgga agacgagaac ggcgacgatc agggtttcca ggaaggggaa   1080

gatgagctcg gggacgaaga ggaaggcgcg ggcgacgaga acgggcacgg ggagcagcag   1140

cctcaaccgc cggcgacgca gcagcaacag ccccaacagc agcgcggggc cgccaaggag   1200

gccgcgggga agagcagcgg ccccacctcg ctgttcgcgg tgacggtggc gccgcccggg   1260

gcgaggcagg gccagcagca ggcgggaggg gacggcaaaa cagaacagaa aggcggagat   1320

aaaaagaggg gtgttaaaag accacgagaa gatcatggcc gtggatattt tgagtacatt   1380

gaagagaaca agtatagcag agccaaatct cctcagccac ctgttgaaga agaagatgaa   1440

cacttcgatg acacagtggt ttgtcttgat acttataatt gtgatctaca ttttaaaata   1500

tcaagagatc gtctcagtgc ttcttccctt acaatggaga gttttgcttt tctttgggct   1560

ggaggaagag catcctatgg tgtgtcaaaa ggcaaagtgt gttttgagat gaaggttaca   1620

gagaagatcc cagtaaggca tttatataca aaagatattg acatacatga agttcgtatt   1680

ggctggtcac taactacaag tggaatgtta cttggtgaag aagaattttc ttatgggtat   1740

tctctaaaag gaataaaaac atgcaactgt gagactgaag attatggaga aaagtttgat   1800

gaaaatgatg tgattacatg ttttgctaac tttgaaagtg atgaagtaga actctcgtat   1860

gctaagaatg gacaagatct tggcgttgcc ttcaaaatca gtaaggaagt tcttgctgga   1920

cggccactgt tcccgcatgt tctctgccac aactgtgcag ttgaatttaa ttttggtcag   1980

aaggaaaagc catattttcc aatacctgaa gagtatactt tcatccagaa cgtcccctta   2040

gaggatcgag ttagaggacc aaaggggcct gaagagaaga aagattgtga agttgtgatg   2100

atgattggct tgccaggagc tggaaaaact acctgggtta ctaaacatgc agcagaaaat   2160

ccagggaaat ataacattct tggcacaaat actattatgg ataagatgat ggtggcaggt   2220

tttaagaagc aaatggcaga tactggaaaa ctgaacacac tgttgcagag agccccccag   2280

tgtcttggga aatttattga gattgctgcc cgaaagaagc gaaattttat tctggatcag   2340

acaaatgtgt ctgctgctgc ccagaggaga aaaatgtgcc tgtttgcagg cttccagcga   2400

aaagctgttg tagtttgccc aaaagatgaa gactataagc aaagaacaca gaagaaagca   2460

gaagtagagg ggaaagacct accagaacat gcggtcctca aaatgaaagg aaactttacc   2520

ctcccagagg tagctgagtg ctttgatgaa ataacctatg ttgaacttca gaaggaagaa   2580

gcccaaaaac tcttggagca atataaggaa gaaagcaaaa aggctcttcc accagaaaag   2640

aaacagaaca ctggctcaaa gaaaagcaat aaaaataaga gtggcaagaa ccagtttaac   2700

agaggtggtg gccatagagg acgtggagga ttcaatatgc gtggtggaaa tttcagagga   2760

ggaggcaacc cctgggaatc gtggcggata taataggagg ggcaacatgc cacagagagg   2820

tggtggcggt ggaggaagtg gtggaatcgg ctatccatac cctcgtgccc ctgtttttcc   2880

tggccgtggt agttactcaa acagagggaa ctacaacaga ggtggaatgc ccaacagagg   2940

gaactacaac cagaacttca gaggacgagg aaacaatcgt ggctacaaaa atcaatctca   3000

gggctacaac cagtggcagc agggtcaatt ctggggtcag aagccatgga gtcagcatta   3060

tcaccaagga tattattgaa tacccaaata aaacgaactg atacatattt ctccaaaacc   3120

ttc                                                                 3123


<210>  2123
<211>  712
<212>  PRT
<213>  Homo sapiens

<400>  2123

Met Ser Ser Ser Pro Val Asn Val Lys Lys Leu Lys Val Ser Glu Leu 
1               5                   10                  15


Lys Glu Glu Leu Lys Lys Arg Arg Leu Ser Asp Lys Gly Leu Lys Ala 
            20                  25                  30


Glu Leu Met Glu Arg Leu Gln Ala Ala Leu Asp Asp Glu Glu Ala Gly 
        35                  40                  45


Gly Arg Pro Ala Met Glu Pro Gly Asn Gly Ser Leu Asp Leu Gly Gly 
    50                  55                  60


Asp Ser Ala Gly Arg Ser Gly Ala Gly Leu Glu Gln Glu Ala Ala Ala 
65                  70                  75                  80


Gly Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ile 
                85                  90                  95


Ser Ala Leu Asp Gly Asp Gln Met Glu Leu Gly Glu Glu Asn Gly Ala 
            100                 105                 110


Ala Gly Ala Ala Asp Ser Gly Pro Met Glu Glu Glu Glu Ala Ala Ser 
        115                 120                 125


Glu Asp Glu Asn Gly Asp Asp Gln Gly Phe Gln Glu Gly Glu Asp Glu 
    130                 135                 140


Leu Gly Asp Glu Glu Glu Gly Ala Gly Asp Glu Asn Gly His Gly Glu 
145                 150                 155                 160


Gln Gln Pro Gln Pro Pro Ala Thr Gln Gln Gln Gln Pro Gln Gln Gln 
                165                 170                 175


Arg Gly Ala Ala Lys Glu Ala Ala Gly Lys Ser Ser Gly Pro Thr Ser 
            180                 185                 190


Leu Phe Ala Val Thr Val Ala Pro Pro Gly Ala Arg Gln Gly Gln Gln 
        195                 200                 205


Gln Ala Gly Gly Asp Gly Lys Thr Glu Gln Lys Gly Gly Asp Lys Lys 
    210                 215                 220


Arg Gly Val Lys Arg Pro Arg Glu Asp His Gly Arg Gly Tyr Phe Glu 
225                 230                 235                 240


Tyr Ile Glu Glu Asn Lys Tyr Ser Arg Ala Lys Ser Pro Gln Pro Pro 
                245                 250                 255


Val Glu Glu Glu Asp Glu His Phe Asp Asp Thr Val Val Cys Leu Asp 
            260                 265                 270


Thr Tyr Asn Cys Asp Leu His Phe Lys Ile Ser Arg Asp Arg Leu Ser 
        275                 280                 285


Ala Ser Ser Leu Thr Met Glu Ser Phe Ala Phe Leu Trp Ala Gly Gly 
    290                 295                 300


Arg Ala Ser Tyr Gly Val Ser Lys Gly Lys Val Cys Phe Glu Met Lys 
305                 310                 315                 320


Val Thr Glu Lys Ile Pro Val Arg His Leu Tyr Thr Lys Asp Ile Asp 
                325                 330                 335


Ile His Glu Val Arg Ile Gly Trp Ser Leu Thr Thr Ser Gly Met Leu 
            340                 345                 350


Leu Gly Glu Glu Glu Phe Ser Tyr Gly Tyr Ser Leu Lys Gly Ile Lys 
        355                 360                 365


Thr Cys Asn Cys Glu Thr Glu Asp Tyr Gly Glu Lys Phe Asp Glu Asn 
    370                 375                 380


Asp Val Ile Thr Cys Phe Ala Asn Phe Glu Ser Asp Glu Val Glu Leu 
385                 390                 395                 400


Ser Tyr Ala Lys Asn Gly Gln Asp Leu Gly Val Ala Phe Lys Ile Ser 
                405                 410                 415


Lys Glu Val Leu Ala Gly Arg Pro Leu Phe Pro His Val Leu Cys His 
            420                 425                 430


Asn Cys Ala Val Glu Phe Asn Phe Gly Gln Lys Glu Lys Pro Tyr Phe 
        435                 440                 445


Pro Ile Pro Glu Glu Tyr Thr Phe Ile Gln Asn Val Pro Leu Glu Asp 
    450                 455                 460


Arg Val Arg Gly Pro Lys Gly Pro Glu Glu Lys Lys Asp Cys Glu Val 
465                 470                 475                 480


Val Met Met Ile Gly Leu Pro Gly Ala Gly Lys Thr Thr Trp Val Thr 
                485                 490                 495


Lys His Ala Ala Glu Asn Pro Gly Lys Tyr Asn Ile Leu Gly Thr Asn 
            500                 505                 510


Thr Ile Met Asp Lys Met Met Val Ala Gly Phe Lys Lys Gln Met Ala 
        515                 520                 525


Asp Thr Gly Lys Leu Asn Thr Leu Leu Gln Arg Ala Pro Gln Cys Leu 
    530                 535                 540


Gly Lys Phe Ile Glu Ile Ala Ala Arg Lys Lys Arg Asn Phe Ile Leu 
545                 550                 555                 560


Asp Gln Thr Asn Val Ser Ala Ala Ala Gln Arg Arg Lys Met Cys Leu 
                565                 570                 575


Phe Ala Gly Phe Gln Arg Lys Ala Val Val Val Cys Pro Lys Asp Glu 
            580                 585                 590


Asp Tyr Lys Gln Arg Thr Gln Lys Lys Ala Glu Val Glu Gly Lys Asp 
        595                 600                 605


Leu Pro Glu His Ala Val Leu Lys Met Lys Gly Asn Phe Thr Leu Pro 
    610                 615                 620


Glu Val Ala Glu Cys Phe Asp Glu Ile Thr Tyr Val Glu Leu Gln Lys 
625                 630                 635                 640


Glu Glu Ala Gln Lys Leu Leu Glu Gln Tyr Lys Glu Glu Ser Lys Lys 
                645                 650                 655


Ala Leu Pro Pro Glu Lys Lys Gln Asn Thr Gly Ser Lys Lys Ser Asn 
            660                 665                 670


Lys Asn Lys Ser Gly Lys Asn Gln Phe Asn Arg Gly Gly Gly His Arg 
        675                 680                 685


Gly Arg Gly Gly Phe Asn Met Arg Gly Gly Asn Phe Arg Gly Gly Gly 
    690                 695                 700


Asn Pro Trp Glu Ser Trp Arg Ile 
705                 710


<210>  2124
<211>  852
<212>  DNA
<213>  Homo sapiens

<400>  2124
ttatagaccg ggaggtattc taggtaaact ttttgtcttt gtctctatcc attttgttag     60

tatcttaaag agatgggagg aaaggcaaga ttaagttggt tctttcaact ctgagggtaa    120

actgccttcc actggctagg cttctgtttt tttccgtagt gtttttgagc tcttaacatc    180

tagcagctaa aaagaattga gtaagtgtaa ggtcttgtta catagtttaa gtgaccctgt    240

ttttgtagca ataatggaca aaggtaatat ttaaattata aaatgttgcc tgctttacat    300

atagatatga gttgaatttt aaaaagcata acttattaaa attcacaagt tcaaggggaa    360

attttaactt ttgaatatag gtggcaggtt ttaagaagca aatggcagat actggaaaac    420

tgaacacact gttgcagaga gccccccagt gtcttgggaa atttattgag attgctgccc    480

gaaagaagcg aaattttatt ctggatcaga caaatgtgtc tgctgctgcc cagaggagaa    540

aaatgtgcct gtttgcaggc ttccagcgaa aagctgttgt agtttgccca aaagatgaag    600

actataagca aagaacacag aagaaagcag aagtagaggg gaaagaccta ccagaacatg    660

cggtcctcaa aatgaaaggc atggaatttt aattctgtta ctgtgtgaaa tcttcttttt    720

aaaagaatgt ttttcctaca tattctgctt gtgtaactat gttaaatcta ttaggactta    780

ggcctcctga aagttaacat tttttccagc aatactgctt caggaattaa aattgcagtt    840

gttacatatg ca                                                        852


<210>  2125
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  2125

Met Ala Asp Thr Gly Lys Leu Asn Thr Leu Leu Gln Arg Ala Pro Gln 
1               5                   10                  15


Cys Leu Gly Lys Phe Ile Glu Ile Ala Ala Arg Lys Lys Arg Asn Phe 
            20                  25                  30


Ile Leu Asp Gln Thr Asn Val Ser Ala Ala Ala Gln Arg Arg Lys Met 
        35                  40                  45


Cys Leu Phe Ala Gly Phe Gln Arg Lys Ala Val Val Val Cys Pro Lys 
    50                  55                  60


Asp Glu Asp Tyr Lys Gln Arg Thr Gln Lys Lys Ala Glu Val Glu Gly 
65                  70                  75                  80


Lys Asp Leu Pro Glu His Ala Val Leu Lys Met Lys Gly Met Glu Phe 
                85                  90                  95


<210>  2126
<211>  1682
<212>  DNA
<213>  Homo sapiens

<400>  2126
acgaagagct ggagaaacac ataagaaggc agatctaaga tggaagaaaa ggcggattcg     60

ggttgaaacg ccaagttgag gactgaagaa agcatttgga taaagcagcc tccaagctgg    120

gaaggagaaa agccaaacga gtatagccac caaagaccca gaaaggccaa tatatcatgc    180

agtgagtcgg ttgaactgaa aggcggtttc cttttcctcc atttgctcag tcccaattgg    240

aagcgcactg cgcggcctcc accgcgctct cggcccgggt tcggcgtggg ggcggggagg    300

taagtacggt aatgggcggg gccgagcgcg ggcgcgctcc ggctttcctc ctgcgcagtg    360

ctcccgtcag cgcagggggc ggggcgccta tattacgtgc gcggcgccgc tcctgcgaga    420

ggacgttgcg tgctcgctcg cgccaggcga gtctccgcgt ctccctcgcg aactcggtga    480

aaggaattgg cgccgttcga caccaggcgg atccgctctg cagcacgaac ccatctccag    540

ccgcagccgc agccgccgcc cgggccgagg agcagccgca gcagccgcca ccagtggccg    600

agtgagcgga gccgagtttg aggcagcgcc tagcggtgaa tcggggattc cgctgggcgc    660

tcgggagcag gcctcgagca ggaggccgcg gccggcggcg atgaagagga ggaggaagag    720

gaagaggagg aggaaggaat ctccgctctg gacggcgacc agatggagct aggagaggag    780

aacggggccg cgggggcggc cgactcgggc ccgatggagg aggaggaggc cgcctcggaa    840

gacgagaacg gcgacgatca gggtttccag gaaggggaag atgagctcgg ggacgaagag    900

gaaggcgcgg gcgacgagaa cgggcacggg gagcagcagc ctcaaccgcc ggcgacgcag    960

cagcaacagc cccaacagca gcgcggggcc gccaaggagg ccgcggggaa gagcagcggc   1020

cccacctcgc tgttcgcggt gacggtggcg ccgcccgggg cgaggcaggg ccagcagcag   1080

gcgggaggta agaagaaggc ggaaggcggc ggaggcggcg gtcgccccgg ggctccggcg   1140

gcgggtgagt gctgcgttgt acgttgcgcg cggcgggagg cccgcgcggg gtggggaccg   1200

tgccccaggc ctgccggagc cccgcagggg gagggagccc cgggcgggag ggcgccgcgg   1260

tgagggtggg ggagggggcg cggggaatcc cagattagcc gagaggcctc gggctcgggg   1320

cgtgtgtgtg cgcgcgcgcg tgtgtgtgtg tgtgtgtgtg tgtgtcggcg gtggcagcgc   1380

ctccattatg tggctcgaga gccgggggga gctgcagctg ccgctgtagg gggaggagcc   1440

gcgggcgggc ggcgggaggg agcccggtcg gcccgcggtg gcgccgtcgc gctgcgtgcg   1500

cgcggtgcgg gcacatgtct cggggggagg ggagaggccc caggtcccgg ggcgggcgcg   1560

ctttggcggc tcctcgccgc tgtattgtgc aaggagcgca ggggctcggc gtgacgtcac   1620

ttccggcggg aggagccggg cggggcgggg cggggggcgg aagatcagta caatgcggcc   1680

gc                                                                  1682


<210>  2127
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  2127

Met Glu Leu Gly Glu Glu Asn Gly Ala Ala Gly Ala Ala Asp Ser Gly 
1               5                   10                  15


Pro Met Glu Glu Glu Glu Ala Ala Ser Glu Asp Glu Asn Gly Asp Asp 
            20                  25                  30


Gln Gly Phe Gln Glu Gly Glu Asp Glu Leu Gly Asp Glu Glu Glu Gly 
        35                  40                  45


Ala Gly Asp Glu Asn Gly His Gly Glu Gln Gln Pro Gln Pro Pro Ala 
    50                  55                  60


Thr Gln Gln Gln Gln Pro Gln Gln Gln Arg Gly Ala Ala Lys Glu Ala 
65                  70                  75                  80


Ala Gly Lys Ser Ser Gly Pro Thr Ser Leu Phe Ala Val Thr Val Ala 
                85                  90                  95


Pro Pro Gly Ala Arg Gln Gly Gln Gln Gln Ala Gly Gly Lys Lys Lys 
            100                 105                 110


Ala Glu Gly Gly Gly Gly Gly Gly Arg Pro Gly Ala Pro Ala Ala Gly 
        115                 120                 125


Glu Cys Cys Val Val Arg Cys Ala Arg Arg Glu Ala Arg Ala Gly Trp 
    130                 135                 140


Gly Pro Cys Pro Arg Pro Ala Gly Ala Pro Gln Gly Glu Gly Ala Pro 
145                 150                 155                 160


Gly Gly Arg Ala Pro Arg 
                165


<210>  2128
<211>  1538
<212>  DNA
<213>  Homo sapiens

<400>  2128
acgaagagct ggagaaacac ataagaaggc agatctaaga tggaagaaaa ggcggattcg     60

ggttgaaacg ccaagttgag gactgaagaa agcatttgga taaagcagcc tccaagctgg    120

gaaggagaaa agccaaacga gtatagccac caaagaccca gaaaggccaa tatatcatgc    180

agtgagtcgg ttgaactgaa aggcggtttc cttttcctcc atttgctcag tcccaattgg    240

aagcgcactg cgcggcctcc accgcgctct cggcccgggt tcggcgtggg ggcggggagg    300

taagtacggt aatgggcggg gccgagcgcg ggcgcgctcc ggctttcctc ctgcgcagtg    360

ctcccgtcag cgcagggggc ggggcgccta tattacgtgc gcggcgccgc tcctgcgaga    420

ggacgttgcg tgctcgctcg cgccaggcga gtctccgcgt ctccctcgcg aactcggtga    480

aaggaattgg cgccgttcga caccaggcgg atccgctctg cagcacgaac ccatctccag    540

ccgcagccgc agccgccgcc cgggccgagg agcagccgca gcagccgcca ccagtggccg    600

agtgagcgga gccgagtttg aggcagcgcc tagcggtgaa tcggggccct caccatgagt    660

tcctcgcctg ttaatgtaaa aaagctgaag gtgtcggagg agaacggcga cgatcagggt    720

ttccaggaag gggaagatga gctcggggac gaagaggaag gcgcgggcga cgagaacggg    780

cacggggagc agcagcctca accgccggcg acgcagcagc aacagcccca acagcagcgc    840

ggggccgcca aggaggccgc ggggaagagc agcggcccca cctcgctgtt cgcggtgacg    900

gtggcgccgc ccggggcgag gcagggccag cagcaggcgg gaggtaagaa gaaggcggaa    960

ggcggcggag gcggcggtcg ccccggggct ccggcggcgg gtgagtgctg cgttgtacgt   1020

tgcgcgcggc gggaggcccg cgcggggtgg ggaccgtgcc ccaggcctgc cggagccccg   1080

cagggggagg gagccccggg cgggagggcg ccgcggtgag ggtgggggag ggggcgcggg   1140

gaatcccaga ttagccgaga ggcctcgggc tcggggcgtg tgtgtgcgcg cgcgcgtgtg   1200

tgtgtgtgtg tgtgtgtgtg tcggcggtgg cagcgcctcc attatgtggc tcgagagccg   1260

gggggagctg cagctgccgc tgtaggggga ggagccgcgg gcgggcggcg ggagggagcc   1320

cggtcggccc gcggtggcgc cgtcgcgctg cgtgcgcgcg gtgcgggcac atgtctcggg   1380

gggaggggag aggccccagg tcccggggcg ggcgcgcttt ggcggctcct cgccgctgta   1440

ttgtgcaagg agcgcagggg ctcggcgtga cgtcacttcc ggcgggagga gccgggcggg   1500

gcggggcggg gggcggaaga tcagtacaat gcggccgc                           1538


<210>  2129
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  2129

Met Ser Ser Ser Pro Val Asn Val Lys Lys Leu Lys Val Ser Glu Glu 
1               5                   10                  15


Asn Gly Asp Asp Gln Gly Phe Gln Glu Gly Glu Asp Glu Leu Gly Asp 
            20                  25                  30


Glu Glu Glu Gly Ala Gly Asp Glu Asn Gly His Gly Glu Gln Gln Pro 
        35                  40                  45


Gln Pro Pro Ala Thr Gln Gln Gln Gln Pro Gln Gln Gln Arg Gly Ala 
    50                  55                  60


Ala Lys Glu Ala Ala Gly Lys Ser Ser Gly Pro Thr Ser Leu Phe Ala 
65                  70                  75                  80


Val Thr Val Ala Pro Pro Gly Ala Arg Gln Gly Gln Gln Gln Ala Gly 
                85                  90                  95


Gly Lys Lys Lys Ala Glu Gly Gly Gly Gly Gly Gly Arg Pro Gly Ala 
            100                 105                 110


Pro Ala Ala Gly Glu Cys Cys Val Val Arg Cys Ala Arg Arg Glu Ala 
        115                 120                 125


Arg Ala Gly Trp Gly Pro Cys Pro Arg Pro Ala Gly Ala Pro Gln Gly 
    130                 135                 140


Glu Gly Ala Pro Gly Gly Arg Ala Pro Arg 
145                 150


<210>  2130
<211>  1724
<212>  DNA
<213>  Homo sapiens

<400>  2130
acgaagagct ggagaaacac ataagaaggc agatctaaga tggaagaaaa ggcggattcg     60

ggttgaaacg ccaagttgag gactgaagaa agcatttgga taaagcagcc tccaagctgg    120

gaaggagaaa agccaaacga gtatagccac caaagaccca gaaaggccaa tatatcatgc    180

agtgagtcgg ttgaactgaa aggcggtttc cttttcctcc atttgctcag tcccaattgg    240

aagcgcactg cgcggcctcc accgcgctct cggcccgggt tcggcgtggg ggcggggagg    300

taagtacggt aatgggcggg gccgagcgcg ggcgcgctcc ggctttcctc ctgcgcagtg    360

ctcccgtcag cgcagggggc ggggcgccta tattacgtgc gcggcgccgc tcctgcgaga    420

ggacgttgcg tgctcgctcg cgccaggcga gtctccgcgt ctccctcgcg aactcggtga    480

aaggaattgg cgccgttcga caccaggcgg atccgctctg cagcacgaac ccatctccag    540

ccgcagccgc agccgccgcc cgggccgagg agcagccgca gcagccgcca ccagtggccg    600

agtgagcgga gccgagtttg aggcagcgcc tagcggtgaa tcggggccct caccatgagt    660

tcctcgcctg ttaatgtaaa aaagctgaag gtgtcggagc tgaaagagga gctcaagaag    720

cgacgccttt ctgacaaggg tctcaaggcc gagctcatgg agcgactcca ggctgcgctg    780

gacgacgagg aggccggggg ccgccccgcc atggagcccg ggaacggcag cctagacctg    840

ggcggggatt ccgctgggcg ctcgggagca ggcctcgagc aggaggccgc ggccggcggc    900

gatgaagagg aggaggaaga ggaagaggag gaggaaggaa tctccgctct ggacggcgac    960

cagatggagc taggagagca gcctcaaccg ccggcgacgc agcagcaaca gccccaacag   1020

cagcgcgggg ccgccaagga ggccgcgggg aagagcagcg gccccacctc gctgttcgcg   1080

gtgacggtgg cgccgcccgg ggcgaggcag ggccagcagc aggcgggagg taagaagaag   1140

gcggaaggcg gcggaggcgg cggtcgcccc ggggctccgg cggcgggtga gtgctgcgtt   1200

gtacgttgcg cgcggcggga ggcccgcgcg gggtggggac cgtgccccag gcctgccgga   1260

gccccgcagg gggagggagc cccgggcggg agggcgccgc ggtgagggtg ggggaggggg   1320

cgcggggaat cccagattag ccgagaggcc tcgggctcgg ggcgtgtgtg tgcgcgcgcg   1380

cgtgtgtgtg tgtgtgtgtg tgtgtgtcgg cggtggcagc gcctccatta tgtggctcga   1440

gagccggggg gagctgcagc tgccgctgta gggggaggag ccgcgggcgg gcggcgggag   1500

ggagcccggt cggcccgcgg tggcgccgtc gcgctgcgtg cgcgcggtgc gggcacatgt   1560

ctcgggggga ggggagaggc cccaggtccc ggggcgggcg cgctttggcg gctcctcgcc   1620

gctgtattgt gcaaggagcg caggggctcg gcgtgacgtc acttccggcg ggaggagccg   1680

ggcggggcgg ggcggggggc ggaagatcag tacaatgcgg ccgc                    1724


<210>  2131
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  2131

Met Ser Ser Ser Pro Val Asn Val Lys Lys Leu Lys Val Ser Glu Leu 
1               5                   10                  15


Lys Glu Glu Leu Lys Lys Arg Arg Leu Ser Asp Lys Gly Leu Lys Ala 
            20                  25                  30


Glu Leu Met Glu Arg Leu Gln Ala Ala Leu Asp Asp Glu Glu Ala Gly 
        35                  40                  45


Gly Arg Pro Ala Met Glu Pro Gly Asn Gly Ser Leu Asp Leu Gly Gly 
    50                  55                  60


Asp Ser Ala Gly Arg Ser Gly Ala Gly Leu Glu Gln Glu Ala Ala Ala 
65                  70                  75                  80


Gly Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ile 
                85                  90                  95


Ser Ala Leu Asp Gly Asp Gln Met Glu Leu Gly Glu Gln Pro Gln Pro 
            100                 105                 110


Pro Ala Thr Gln Gln Gln Gln Pro Gln Gln Gln Arg Gly Ala Ala Lys 
        115                 120                 125


Glu Ala Ala Gly Lys Ser Ser Gly Pro Thr Ser Leu Phe Ala Val Thr 
    130                 135                 140


Val Ala Pro Pro Gly Ala Arg Gln Gly Gln Gln Gln Ala Gly Gly Lys 
145                 150                 155                 160


Lys Lys Ala Glu Gly Gly Gly Gly Gly Gly Arg Pro Gly Ala Pro Ala 
                165                 170                 175


Ala Gly Glu Cys Cys Val Val Arg Cys Ala Arg Arg Glu Ala Arg Ala 
            180                 185                 190


Gly Trp Gly Pro Cys Pro Arg Pro Ala Gly Ala Pro Gln Gly Glu Gly 
        195                 200                 205


Ala Pro Gly Gly Arg Ala Pro Arg 
    210                 215


<210>  2132
<211>  1036
<212>  DNA
<213>  Homo sapiens

<400>  2132
acgaagagct ggagaaacac ataagaaggc agatctaaga tggaagaaaa ggcggattcg     60

ggttgaaacg ccaagttgag gactgaagaa agcatttgga taaagcagcc tccaagctgg    120

gaaggagaaa agccaaacga gtatagccac caaagaccca gaaaggccaa tatatcatgc    180

agtgagtcgg ttgaactgaa aggcggtttc cttttcctcc atttgctcag tcccaattgg    240

aagcgcactg cgcggcctcc accgcgctct cggcccgggt tcggcgtggg ggcggggagg    300

taagtacggt aatgggcggg gccgagcgcg ggcgcgctcc ggctttcctc ctgcgcagtg    360

ctcccgtcag cgcagggggc ggggcgccta tattacgtgc gcggcgccgc tcctgcgaga    420

ggacgttgcg tgctcgctcg cgccaggcga gtctccgcgt ctccctcgcg aactcggtga    480

aaggaattgg cgccgttcga caccaggcgg atccgctctg cagcacgaac ccatctccag    540

ccgcagccgc agccgccgcc cgggccgagg agcagccgca gcagccgcca ccagtggccg    600

agtgagcgga gccgagtttg aggcagcgcc tagcggtgaa tcggggccct caccatgagt    660

tcctcgcctg ttaatgtaaa aaagctgaag gtgtcggagc tgaaagagga gctcaagaag    720

cgacgccttt ctgacaaggg tctcaaggcc gagctcatgg agcgactcca ggctgcgctg    780

gacgacgagg aggccggggg ccgccccgcc atggagcccg ggaacggcag cctagacctg    840

ggcggggatt ccgctgggcg ctcgggagca ggcctcgagc aggaggccgc ggccggcggc    900

gatgaagagg aggccgcctc ggaagacgag aacggcgacg atcagggttt ccaggaaggg    960

gaagatgagc tcggggacga agaggaaggc gcgggcgacg agaacgggca cggggagcag   1020

cagcctcaac cgccgg                                                   1036


<210>  2133
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  2133

Met Ser Ser Ser Pro Val Asn Val Lys Lys Leu Lys Val Ser Glu Leu 
1               5                   10                  15


Lys Glu Glu Leu Lys Lys Arg Arg Leu Ser Asp Lys Gly Leu Lys Ala 
            20                  25                  30


Glu Leu Met Glu Arg Leu Gln Ala Ala Leu Asp Asp Glu Glu Ala Gly 
        35                  40                  45


Gly Arg Pro Ala Met Glu Pro Gly Asn Gly Ser Leu Asp Leu Gly Gly 
    50                  55                  60


Asp Ser Ala Gly Arg Ser Gly Ala Gly Leu Glu Gln Glu Ala Ala Ala 
65                  70                  75                  80


Gly Gly Asp Glu Glu Glu Ala Ala Ser Glu Asp Glu Asn Gly Asp Asp 
                85                  90                  95


Gln Gly Phe Gln Glu Gly Glu Asp Glu Leu Gly Asp Glu Glu Glu Gly 
            100                 105                 110


Ala Gly Asp Glu Asn Gly His Gly Glu Gln Gln Pro Gln Pro 
        115                 120                 125


<210>  2134
<211>  508
<212>  DNA
<213>  Homo sapiens

<400>  2134
gagaggacgt tgcgtgctcg ctcgcgccag gcgagtctcc gcgtctccct cgcgaactcg     60

gtgaaaggaa ttggcgccgt tcgacaccag gcggatccgc tctgcagcac gaacccatct    120

ccagccgcag ccgcagccgc cgcccgggcc gaggagcagc cgcagcagcc gccaccagtg    180

gccgagtgag cggagccgag tttgaggcag cgcctagcgg tgaatcgggg ccctcaccat    240

gagttcctcg cctgttaatg taaaaaagct gaaggtgtcg gagctgaaag aggagctcaa    300

gaagcgacgc ctttctgaca agggtctcaa ggccgagctc atggagcgac tccaggctgc    360

gctggacgac gaggaggccg actcgggccc gatggaggag gaggaggccg cctcggaaga    420

cgagaacggc gacgatcagg gtttccagga aggggaagat gagctcgggg acgaagagga    480

aggcgcgggc gacgagaacg ggcacggg                                       508


<210>  2135
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  2135

Met Ser Ser Ser Pro Val Asn Val Lys Lys Leu Lys Val Ser Glu Leu 
1               5                   10                  15


Lys Glu Glu Leu Lys Lys Arg Arg Leu Ser Asp Lys Gly Leu Lys Ala 
            20                  25                  30


Glu Leu Met Glu Arg Leu Gln Ala Ala Leu Asp Asp Glu Glu Ala Asp 
        35                  40                  45


Ser Gly Pro Met Glu Glu Glu Glu Ala Ala Ser Glu Asp Glu Asn Gly 
    50                  55                  60


Asp Asp Gln Gly Phe Gln Glu Gly Glu Asp Glu Leu Gly Asp Glu Glu 
65                  70                  75                  80


Glu Gly Ala Gly Asp Glu Asn Gly His 
                85


<210>  2136
<211>  2598
<212>  DNA
<213>  Homo sapiens

<400>  2136
aaattggatg gaaagaaatt ctgtgtgctc ccaggattcc agttccttac cggaggttgg     60

tgccgtctga gtctgaaaag ctgccctctt gccgtgttca tgctttggta gaacaccttc    120

agagccttgg caagctctcg gtcagagccg gcttgctgtg tgcacatttg gctcatctcc    180

ccggcggatg gcagttgcgc agtcatcccg ctgatcttca gagtgttgga aggcttcggg    240

gctgaggtgg aaaaaggtaa cattgattta tgtatctctt tctctgggca tctctatatt    300

tattttggtg gcattctact gcatcagcat ttatcaggca ccagtttgga tccatccaag    360

ggaaagggga aatctcacag ggcagaagaa atgtccggca ttttttgttt atgaaagaag    420

atacgaatta actcatttaa aagtttgttt cttaaaagac aaatacacat cccaaatgta    480

ggagtctagg gataagctaa acagccaaga ctggagcagt ctctcacctt gaccagaagc    540

agttttcgca agtgatgctt tgagaagcac gttctcctct ctcagggctc tgttaatgtt    600

cctgagcggt tccgtctcct gctctagctt gagcagcttc agataaagtt ctggtatctg    660

gtttgatgct gcctaccaga aaacatgtca gtttcgtctt ttgttgtatc atctgcatat    720

cctttgagac tggcaatgtt tgctaccatg ggaaaatcaa atgggatggg agtgtgtgta    780

tggtgagcag agtttaagcc cctcagggta cacaggagta aataaagaaa acgtttgtta    840

agggggaagg aacgtcaagc agccgtcctc agagattttc tagccacctg ggatgcccac    900

tttagtgtcc tatgtacaca cctggcttat atccttcaca gtggaaattt tcttggtgtc    960

taccaggatg tggccttcac ctgtgaccat gaggcccagc tgagagcagc tcagctcggt   1020

gcagccttct gtaatgggga gagacacagt caaagaaaga aacatcccag tcgcccagct   1080

ccagtgtcag cttcatgcag taggccagcg actggagcca gatgtgagct gagcccaagc   1140

ggacgacctc gacaggatcc cagaaagggt cgtcatctcg agccacaggg ccgtgatctc   1200

catctagaaa gcgctggtaa agttcctgca ttaggaattt cctattgatg aacttggctt   1260

ttgaccatat ccacacctgg aaacacagag gggtccacac ccagtgcaca gcagatccag   1320

gacaacagcc tgccgctgtc ttcctcctca ctgggtgagg acagggcctc tgtcagcact   1380

ggctctggag aggaaacaaa cctgaagcca caggaggagg gattccagag ggattccagc   1440

cgccctctcc agctggaaga agtcgtaatc gaacctgctc aggtcctcac tgccccactc   1500

cgaaggaaac cccacgtaca ggtgaggtca gaggagtgaa gtgacttgcc caagaccaca   1560

cagtgagtca ggagcaggcc tgtccctcca gcagtggtgc catgttgtcc ccaagccatg   1620

gtggcagagg agctggtgtg aacgccccat cctgccacgt ctgtgatgtg ggcacctcac   1680

atgactgtcc cctcccagct cttggggggg acctaggaca ttctgtgagc ctgcaggaaa   1740

gtttaccaaa tgctgcagct ttgtcctggt ggtgatgggc accccgttaa cggcaacctt   1800

gcatttgcta tgtggagtga ccgtcacttt accgtcggca tttgtgaagg aagcgtgttt   1860

atctgaaatt ctaagaagat gagagtcaaa gacacccagc aaacggcggt ttccgtgagc   1920

aggtaggctg acctttctca tgtgcacagg agggaaggtc tacagctgcg gaggatggca   1980

ggtggcatct cggggcctcc tgtgtgctgt ggcccatgat gcatggggac agcagcgggc   2040

gcagaaggac cctgcccttg gggagcacgg ggagctggga gacagcaggc aagggcttca   2100

ttaacagaac gaacaccagc tgagggccta gcactgcggg gagccggcca aggccacact   2160

ggagtcctcc cgctcccagg ccagcgggat ggggtggtgg gaagatggca gcaagcaagc   2220

ttcagaagag acgctcagga ggcgactctt aacgagcctc acctactccg gggttggagc   2280

ccaggaagca aaccagcact gcaccctaga tttcagccag aggacgaaag ccctgccctc   2340

agctttctca gaccagccct ggagtaggtg gcccggggag acctgggcag tgtccctgct   2400

tgtcctgcag actgtgtggc tctgcagacc tctagatgga ggaggcacaa ttctctaatg   2460

ctggacgagg acactgatca tggaaactca ccccaaacct tgaatcgtga tagcatttga   2520

ggcagcctga ccggtgccac atgaacctga aaggaatcaa gatataattt attttgaaaa   2580

taaatcagac actttcag                                                 2598


<210>  2137
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  2137

Met Gly Thr Ala Ala Gly Ala Glu Gly Pro Cys Pro Trp Gly Ala Arg 
1               5                   10                  15


Gly Ala Gly Arg Gln Gln Ala Arg Ala Ser Leu Thr Glu Arg Thr Pro 
            20                  25                  30


Ala Glu Gly Leu Ala Leu Arg Gly Ala Gly Gln Gly His Thr Gly Val 
        35                  40                  45


Leu Pro Leu Pro Gly Gln Arg Asp Gly Val Val Gly Arg Trp Gln Gln 
    50                  55                  60


Ala Ser Phe Arg Arg Asp Ala Gln Glu Ala Thr Leu Asn Glu Pro His 
65                  70                  75                  80


Leu Leu Arg Gly Trp Ser Pro Gly Ser Lys Pro Ala Leu His Pro Arg 
                85                  90                  95


Phe Gln Pro Glu Asp Glu Ser Pro Ala Leu Ser Phe Leu Arg Pro Ala 
            100                 105                 110


Leu Glu 



<210>  2138
<211>  2976
<212>  DNA
<213>  Homo sapiens

<400>  2138
aaattggatg gaaagaaatt ctgtgtgctc ccaggattcc agttccttac cggaggttgg     60

tgccgtctga gtctgaaaag ctgccctctt gccgtgttca tgctttggta gaacaccttc    120

agagccttgg caagctctcg gtcagagccg gcttgctgtg tgcacatttg gctcatctcc    180

ccggcggatg gcagttgcgc agtcatcccg ctgatcttca gagtgttgga aggcttcggg    240

gctgaggtgg aaaaaggtaa cattgattta tgtatctctt tctctgggca tctctatatt    300

tattttggtg gcattctact gcatcagcat ttatcaggca ccagtttgga tccatccaag    360

ggaaagggga aatctcacag ggcagaagaa atgtccggca ttttttgttt atgaaagaag    420

atacgaatta actcatttaa aagtttgttt cttaaaagac aaatacacat cccaaatgta    480

ggagtctagg gataagctaa acagccaaga ctggagcagt ctctcacctt gaccagaagc    540

agttttcgca agtgatgctt tgagaagcac gttctcctct ctcagggctc tgttaatgtt    600

cctgagcggt tccgtctcct gctctagctt gagcagcttc agataaagtt ctggtatctg    660

gtttgatgct gcctaccaga aaacatgtca gtttcgtctt ttgttgtatc atctgcatat    720

cctttgagac tggcaatgtt tgctaccatg ggaaaatcaa atgggatggg agtgtgtgta    780

tggtgagcag agtttaagcc cctcagggta cacaggagta aataaagaaa acgtttgtta    840

agggggaagg aacgtcaagc agccgtcctc agagattttc tagccacctg ggatgcccac    900

tttagtgtcc tatgtacaca cctggcttat atccttcaca gtggaaattt tcttggtgtc    960

taccaggatg tggccttcac ctgtgaccat gaggcccagc tgagagcagc tcagctcggt   1020

gcagccttct gtaatgggga gagacacagt caaagaaaga aacatcccag tcgcccagct   1080

ccagtgtcag cttcatgcag taggccagcg actggagcca gatgtgagct gagcccaagc   1140

ggacgacctc gacaggatcc cagaaagggt cgtcatctcg agccacaggg ccgtgatctc   1200

catctagaaa gcgctggtaa agttcctgca ttaggaattt cctattgatg aacttggctt   1260

ttgaccatat ccacacctgg aaacacagag gggtccacac ccagtgcaca gcagatccag   1320

gacaacagcc tgccgctgtc ttcctcctca ctgggtgagg acagggcctc tgtcagcact   1380

ggctctggag aggaaacaaa cctgaagcca caggaggagg gattccagag ggattccagc   1440

cgccctctcc agctggaaga agtcgtaatc gaacctgctc aggtcctcac tgccccactc   1500

cgaaggaaac cccacgtaca ggtgaggtca gaggagtgaa gtgacttgcc caagaccaca   1560

cagtgagtca ggagcaggcc tgtccctcca gcagtggtgc catgttgtcc ccaagccatg   1620

gtggcagagg agctggtgtg aacgccccat cctgccacgt ctgtgatgtg ggcacctcac   1680

atgactgtcc cctcccagct cttggggggg acctaggaca ttctgtgagc ctgcaggaaa   1740

gtttaccaaa tgctgcagct ttgtcctggt ggtgatgggc accccgttaa cggcaacctt   1800

gcatttgcta tgtggagtga ccgtcacttt accgtcggca tttgtgaagg aagcgtgttt   1860

atctgaaatt ctaagaagat gagagtcaaa gacacccagc aaacggcggt ttccgtgagc   1920

aggtaggctg acctttctca tgtgcacagg agggaaggtc tacagctgcg gaggatggca   1980

ggtggcatct cggggcctcc tgtgtgctgt ggcccatgat gcatggggac agcagcgggc   2040

gcagaaggac cctgcccttg gggagcacgg ggagctggga gacagcaggc aagggcttca   2100

ttaacagaac gaacaccagc tgagggccta gcactgcggg gagccggcca aggccacact   2160

ggagtcctcc cgctcccagg ccagcgggat ggggtggtgg gaagatggca gcaagcaagc   2220

ttcagaagag acgctcagga ggcgactctt aacgagcctc acctactccg gggttggagc   2280

ccaggaagca aaccagcact gcaccctaga tttcagccag aggacgaaag ccctgccctc   2340

agctttctca gaccagccct ggagtaggtg gcccggggag acctgggcag tgtccctgct   2400

tgtcctgcag actgtgtggc tctgcagacc tctagatgga ggaggcacaa ttctctaatg   2460

ctggacgagg acactgatca tggaaactca ccccaaacct tgaatcgtga tagcatttga   2520

ggcagcctga ccggtgccac atgaacctga aaggaatcaa gatataattt attttgaaaa   2580

taaatcagac actttcagaa tttgagcgta agaagttaac atgtctgatg cgttggaagt   2640

gacgttttct ctacagtggg atggtactga agggattttt ccagttggga ttttcaatca   2700

taatggtact tagacatact tttctttctg ccttgtgtgt ggggggaaga gcggggatgt   2760

tcctaacttt taaaaagttc caccttcttc atgagcattc tggaggaaga caccattagg   2820

tctgggcctt aggagaccca ctgaatactg gccacagcag aggttctggt gtttgaagct   2880

ccgtttctgt gtagtgactg accccaagga gtgcagacat gtcacccccc acatccccac   2940

atcccacggc catctcgcac ggagccctcg cggccg                             2976


<210>  2139
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  2139

Met Gly Thr Ala Ala Gly Ala Glu Gly Pro Cys Pro Trp Gly Ala Arg 
1               5                   10                  15


Gly Ala Gly Arg Gln Gln Ala Arg Ala Ser Leu Thr Glu Arg Thr Pro 
            20                  25                  30


Ala Glu Gly Leu Ala Leu Arg Gly Ala Gly Gln Gly His Thr Gly Val 
        35                  40                  45


Leu Pro Leu Pro Gly Gln Arg Asp Gly Val Val Gly Arg Trp Gln Gln 
    50                  55                  60


Ala Ser Phe Arg Arg Asp Ala Gln Glu Ala Thr Leu Asn Glu Pro His 
65                  70                  75                  80


Leu Leu Arg Gly Trp Ser Pro Gly Ser Lys Pro Ala Leu His Pro Arg 
                85                  90                  95


Phe Gln Pro Glu Asp Glu Ser Pro Ala Leu Ser Phe Leu Arg Pro Ala 
            100                 105                 110


Leu Glu 



<210>  2140
<211>  595
<212>  DNA
<213>  Homo sapiens

<400>  2140
agctgccctc ttgccgtgtt catgctttgg tagaacacct tcagagcctt ggcaagctct     60

cggtcagagc cggcttgctg tgtgcacatt tggctcatct ccccggcgga tggcagttgc    120

gcagtcatcc cgctgatctt cagagtgttg gaaggcttcg gggctgaggt ggaaaaagga    180

tgtggccttc acctgtgacc atgaggccca gctgagagca gctcagctcg gtgcagcctt    240

ctgtaatggg gagagacaca gtcaaagaaa gaaacatccc agtcgcccag ctccagtgtc    300

agcttcatgc agtaggccag cgactggagc cagatgtgag ctgagcccaa gcggacgacc    360

tcgacaggat cccagaaagg gtcgtcatct cgagccacag ggccgtgatc tccatctaga    420

aagcgctggt aaagttcctg cattaggaat ttcctattga tgaacttggc ttttgaccat    480

atccacacct ggaaacacag aggaaagcag agagacacag tgtgaaatcg ctgctctcag    540

atcagcacac gggagaggcc agcagtcagg agggggctca ccgagtttgt ctgca         595


<210>  2141
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  2141

Met Gly Arg Asp Thr Val Lys Glu Arg Asn Ile Pro Val Ala Gln Leu 
1               5                   10                  15


Gln Cys Gln Leu His Ala Val Gly Gln Arg Leu Glu Pro Asp Val Ser 
            20                  25                  30


<210>  2142
<211>  558
<212>  DNA
<213>  Homo sapiens

<400>  2142
agggacttaa catggaattg aaggtgaaaa atttggcatc gtcagattcc aggggctatg     60

acctacagaa ggaggtcttg gtgaaggtga cccaccacgg gtctcacgag gcattatcct    120

atctctgacc ctctcttctg cttctctcgg ccatattgaa gacccttgtg atttcattgg    180

ggccacctgg atactccagg ctaatctccg tattttaagg tgtggatatg gtcaaaagcc    240

aagttcatca ataggaaatt cctaatgcag gaactttacc agcgctttct agatggagat    300

cacggccctg tggctcgaga tgacgaccct ttctgggatc ctgtcgaggt cgtccgcttg    360

ggctcagctc acatctggct ccagtcgctg gcctactgca tgaagctgga ggagcaagtg    420

gagtttctga actgtgatgg gctggaggag gcggtgctgc atacctgcat agcaccctgc    480

tccccaacag gacaaacgca tggcgaggag gatgtggtta ttgacccttt ggagctgctg    540

ggcaagagga tggatttt                                                  558


<210>  2143
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  2143

Met Gln Glu Leu Tyr Gln Arg Phe Leu Asp Gly Asp His Gly Pro Val 
1               5                   10                  15


Ala Arg Asp Asp Asp Pro Phe Trp Asp Pro Val Glu Val Val Arg Leu 
            20                  25                  30


Gly Ser Ala His Ile Trp Leu Gln Ser Leu Ala Tyr Cys Met Lys Leu 
        35                  40                  45


Glu Glu Gln Val Glu Phe Leu Asn Cys Asp Gly Leu Glu Glu Ala Val 
    50                  55                  60


Leu His Thr Cys Ile Ala Pro Cys Ser Pro Thr Gly Gln Thr His Gly 
65                  70                  75                  80


Glu Glu Asp Val Val Ile Asp Pro Leu Glu Leu Leu Gly Lys Arg Met 
                85                  90                  95


Asp 



<210>  2144
<211>  554
<212>  DNA
<213>  Homo sapiens

<400>  2144
gtgtagatgg aggcttctgg aaggctgtgg tctgggggtc tcttgtgaca cgtattcacc     60

caacagctgt tggctctggt gagcagcaca tcctgccagg gaactctgag ccaggcctgc    120

agagcccacc cgggagcagg cgggagtcag catgggctcg cagcctatcc tggagcctcg    180

ccgacctgtt tcctcctcag gccaaggatg acatgcaatt ttaactgaca ccaggcctgt    240

ggtctgatat ccagagttgc tcagaaaagg agttgctagt tttacctgat atttatggtc    300

taaaaacgac ctacctggaa tccctctgga atccctcctc ctgtggcttc aggcattatc    360

ctatctctga ccctctcttc tgcttctctc ggccatattg aagacccttg tgatttcatt    420

ggggccacct ggatactcca ggctaatctc cgtattttaa ggtgtggata tggtcaaaag    480

ccaagttcat caataggaaa ttcctaatgc aggaacttta ccagcgcttt ctagatggag    540

atcacggccc tgtg                                                      554


<210>  2145
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  2145

Lys Arg Pro Thr Trp Asn Pro Ser Gly Ile Pro Pro Pro Val Ala Ser 
1               5                   10                  15


Gly Ile Ile Leu Ser Leu Thr Leu Ser Ser Ala Ser Leu Gly His Ile 
            20                  25                  30


Glu Asp Pro Cys Asp Phe Ile Gly Ala Thr Trp Ile Leu Gln Ala Asn 
        35                  40                  45


Leu Arg Ile Leu Arg Cys Gly Tyr Gly Gln Lys Pro Ser Ser Ser Ile 
    50                  55                  60


Gly Asn Ser 
65


<210>  2146
<211>  278
<212>  DNA
<213>  Homo sapiens

<400>  2146
gagaggaaac aaacctgaag ccacaggagg agggattcca gagggattcc aggtaggtcg     60

tttttagacc ataaatatca ggtaaaacta gcaactcctt ttctgagcaa ctggaaaagc    120

aaaagcaaaa atcagcagac aagtcgttcc atgtatgatg tctcttcata aaaaggacat    180

tctcaggact ctgaaaacag attccatctt tgttggcctc aaagtgaaga accgaatcaa    240

gatataattt attttgaaaa taaatcagac actttcag                            278


<210>  2147
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  2147

Met Met Ser Leu His Lys Lys Asp Ile Leu Arg Thr Leu Lys Thr Asp 
1               5                   10                  15


Ser Ile Phe Val Gly Leu Lys Val Lys Asn Arg Ile Lys Ile 
            20                  25                  30


<210>  2148
<211>  2921
<212>  DNA
<213>  Homo sapiens

<400>  2148
cagcagagac cggcagcggc gggcggcccg cgtgggctac tgctgggggc tgcgttcggg     60

cgaggagggg agattctgtc tcagaggcct cgggctgcac gttcttccgg gccgcgcatt    120

tgcagcccac agcaggcccc agccggcccc tctggagttg ggccactgct tctgcaggcc    180

cagcaggccc ctgggggcgg ccggaggcca ctaactggct tctccagctc agcattcttc    240

tctcatttgc tgggtacccc actctcttct ctaccccttt gaaccatctt taccctcatt    300

cctcagggaa cgtttaacga gttgaatgtt taccatgtag tcactctata tggaaatcat    360

aattcaattt tgtaaacatc agactttgac aaaacaaatg atgatgttct taaggaaagc    420

agagagacac agtgtgaaat cgctgctctc agatcagcac acgggagagg ccagcagtca    480

ggagggggct caccgagttt gtctgcactc gctccctccg cagccgccct ctccagctgg    540

aagaagtcgt aatcgaacct gctcaggtcc tcactgcccc actccgaagg aaaccccacg    600

tacaggtgag gtcagaggag tgaagtgact tgcccaagac cacacagtga gtcaggagca    660

ggcctgtccc tccagcagtg gtgccatgtt gtccccaagc catggtggca gaggagctgg    720

tgtgaacgcc ccatcctgcc acgtctgtga tgtgggcacc tcacatgact gtcccctccc    780

agctcttggg ggggacctag gacattctgt gagcctgcag gaaagtttac caaatgctgc    840

agctttgtcc tggtggtgat gggcaccccg ttaacggcaa ccttgcattt gctatgtgga    900

gtgaccgtca ctttaccgtc ggcatttgtg aaggaagcgt gtttatctga aattctaaga    960

agatgagagt caaagacacc cagcaaacgg cggtttccgt gagcaggtag gctgaccttt   1020

ctcatgtgca caggagggaa ggtctacagc tgcggaggat ggcaggtggc atctcggggc   1080

ctcctgtgtg ctgtggccca tgatgcatgg ggacagcagc gggcgcagaa ggaccctgcc   1140

cttggggagc acggggagct gggagacagc aggcaagggc ttcattaaca gaacgaacac   1200

cagctgaggg cctagcactg cggggagccg gccaaggcca cactggagtc ctcccgctcc   1260

caggccagcg ggatggggtg gtgggaagat ggcagcaagc aagcttcaga agagacgctc   1320

aggaggcgac tcttaacgag cctcacctac tccgggtacg ttttgatctg tttctgcgcc   1380

ctcgccgtat aaattcagac cttataggat ttggggctgg acgtcggggt gtcaggttgg   1440

catcccctct ccccgccctg ctcccctgca ccgatgtcat ctgtgtgtcc tgaatgactg   1500

gctccctgcc ttagcatgtt ccatgttcct gcactccttg gccatcatgg aatgttctgg   1560

atgtggagac ccgtgtgcat ccaaaccctt ttttgcatgg ggcccaggga tcctgtggga   1620

aaggttgcgg cctcatcact ggagttcaga catttacgca cctgtgcgtt ggactaagga   1680

cgtgttctgg aaagggactt gagggggatc cccaggaaga tgtcccaaga aggaggctgg   1740

cagtgcagga cgaggcgggg ccagccggcc cctgggtcag cacccctcca gccacgacgg   1800

cccgtgggct ttcgtacggg ggcagggggt gatctgtctg aaggatgtag gtgatggtgc   1860

ttcccagctg gagagctgga agcaggagga ggacactcca gcagcagcct cccaggcagg   1920

gcagccacag agctggggac agctcttgac tgggtgaggc ccggcatggg gtttcccagg   1980

gctcctgcgg ggcctcctga gggagccctt ggggtcactc cacagtctgg gctttctgta   2040

gtccggtggg tcagggctcc aagcaccagg agagatccag ggatgcgctt atgtttgggc   2100

cacccccggt gggcttgttc gttcagcccc cttcgtttcc tggcctgctc tacttatatc   2160

tgtttgtgaa gaattattac acagaatcta gaaaccagct ttcccttttc tcccagggtt   2220

ggagcccagg aagcaaacca gcactgcacc ctagatttca gccagaggac gaaagccctg   2280

ccctcagctt tctcagacca gccctggagt aggtggcccg gggagacctg ggcagtgtcc   2340

ctgcttgtcc tgcagactgt gtggctctgc agacctctag atggaggagg cacaattctc   2400

taatgctgga cgaggacact gatcatggaa actcacccca aaccttgaat cgtgatagca   2460

tttgaggcag cctgaccggt gccacatgaa cctgaaagga atcaagatat aatttatttt   2520

gaaaataaat cagacacttt cagaatttga gcgtaagaag ttaacatgtc tgatgcgttg   2580

gaagtgacgt tttctctaca gtgggatggt actgaaggga tttttccagt tgggattttc   2640

aatcataatg gtacttagac atacttttct ttctgccttg tgtgtggggg gaagagcggg   2700

gatgttccta acttttaaaa agttccacct tcttcatgag cattctggag gaagacacca   2760

ttaggtctgg gccttaggag acccactgaa tactggccac agcagaggtt ctggtgtttg   2820

aagctccgtt tctgtgtagt gactgacccc aaggagtgca gacatgtcac cccccacatc   2880

cccacatccc acggccatct cgcacggagc cctcgcggcc g                       2921


<210>  2149
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  2149

Met Glu Ile Ile Ile Gln Phe Cys Lys His Gln Thr Leu Thr Lys Gln 
1               5                   10                  15


Met Met Met Phe Leu Arg Lys Ala Glu Arg His Ser Val Lys Ser Leu 
            20                  25                  30


Leu Ser Asp Gln His Thr Gly Glu Ala Ser Ser Gln Glu Gly Ala His 
        35                  40                  45


Arg Val Cys Leu His Ser Leu Pro Pro Gln Pro Pro Ser Pro Ala Gly 
    50                  55                  60


Arg Ser Arg Asn Arg Thr Cys Ser Gly Pro His Cys Pro Thr Pro Lys 
65                  70                  75                  80


Glu Thr Pro Arg Thr Gly Glu Val Arg Gly Val Lys 
                85                  90


<210>  2150
<211>  928
<212>  DNA
<213>  Homo sapiens

<400>  2150
tcttgggggg gacctaggac attctgtgag cctgcaggaa agtttaccaa atgctgcagc     60

tttgtcctgg tggtgatggg caccccgtta acggcaacct tgcatttgct atgtggagtg    120

accgtcactt taccgtcggc atttgtgaag gaagcgtgtt tatctgaaat tctaagaaga    180

tgagagtcaa agacacccag caaacggcgg tttccgtgag cagggttgga gcccaggaag    240

caaaccagca ctgcacccta gatttcagcc agaggacgaa agccctgccc tcagctttct    300

cagaccagcc ctggagtagg tggcccgggg agacctgggc agtgtccctg cttgtcctgc    360

agactgtgtg gctctgcaga cctctagatg gaggaggcac aattctctaa tgctggacga    420

ggacactgat catggaaact caccccaaac cttgaatcgt gatagcattt gaggcagcct    480

gaccggtgcc acatgaacct gaaaggaatc aagatataat ttattttgaa aataaatcag    540

acactttcag aatttgagcg taagaagtta acatgtctga tgcgttggaa gtgacgtttt    600

ctctacagtg ggatggtact gaagggattt ttccagttgg gattttcaat cataatggta    660

cttagacata cttttctttc tgccttgtgt gtggggggaa gagcggggat gttcctaact    720

tttaaaaagt tccaccttct tcatgagcat tctggaggaa gacaccatta ggtctgggcc    780

ttaggagacc cactgaatac tggccacagc agaggttctg gtgtttgaag ctccgtttct    840

gtgtagtgac tgaccccaag gagtgcagac atgtcacccc ccacatcccc acatcccacg    900

gccatctcgc acggagccct cgcggccg                                       928


<210>  2151
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  2151

Met Arg Val Lys Asp Thr Gln Gln Thr Ala Val Ser Val Ser Arg Val 
1               5                   10                  15


Gly Ala Gln Glu Ala Asn Gln His Cys Thr Leu Asp Phe Ser Gln Arg 
            20                  25                  30


Thr Lys Ala Leu Pro Ser Ala Phe Ser Asp Gln Pro Trp Ser Arg Trp 
        35                  40                  45


Pro Gly Glu Thr Trp Ala Val Ser Leu Leu Val Leu Gln Thr Val Trp 
    50                  55                  60


Leu Cys Arg Pro Leu Asp Gly Gly Gly Thr Ile Leu 
65                  70                  75


<210>  2152
<211>  535
<212>  DNA
<213>  Homo sapiens

<400>  2152
aggacattct gtgagcctgc aggaaagttt accaaatgct gcagctttgt cctggtggtg     60

atgggcaccc cgttaacggc aaccttgcat ttgctatgtg gagtgaccgt cactttaccg    120

tcggcatttg tgaaggaagc gtgtttatct gaaattctaa gaagatgaga gtcaaagaca    180

cccagcaaac ggcggtttcc gtgagcaggg ttggagccca ggaagcaaac cagcactgca    240

ccctagattt cagccagagg acgaaagccc tgccctcagc tttctcagac cagccctgga    300

gtaggtggcc cggggagacc tgggcagtgt ccctgcttgt cctgcagact gtgtggctct    360

gcagacctct agatggagga ggcacaattc tctaatgctg gacgaggaca ctgatcatgg    420

aaactcaccc caaaccttga atcgtgatag catttgaggc agcctgaccg gtgccacatg    480

aacctgaaag gaatcaagat ataatttatt ttgaaaataa atcagacact ttcag         535


<210>  2153
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  2153

Met Arg Val Lys Asp Thr Gln Gln Thr Ala Val Ser Val Ser Arg Val 
1               5                   10                  15


Gly Ala Gln Glu Ala Asn Gln His Cys Thr Leu Asp Phe Ser Gln Arg 
            20                  25                  30


Thr Lys Ala Leu Pro Ser Ala Phe Ser Asp Gln Pro Trp Ser Arg Trp 
        35                  40                  45


Pro Gly Glu Thr Trp Ala Val Ser Leu Leu Val Leu Gln Thr Val Trp 
    50                  55                  60


Leu Cys Arg Pro Leu Asp Gly Gly Gly Thr Ile Leu 
65                  70                  75


<210>  2154
<211>  2969
<212>  DNA
<213>  Homo sapiens

<400>  2154
tacgcctagg agaggaagga gaaagaaaga agttaatcag gacatactag aaaacaccag     60

ttctgtggaa caagaattac agatcactac aggtagggaa tcaaaaagat taaaatcatc    120

tcagctgttg gaaccagcag ttgaagaaac tactaaaaaa gaagttaagg tttcatctgt    180

tacaaaaagg actcctagaa gaattaaaag atctgtagaa aatcaggaaa gtgttgaaat    240

tataaatgat ctaaaagtta gtacggtaac aagtcctagc agaatgatca gaaaattgag    300

aagtactaat ttagatgctt ctgaaaatac aggaaataag caagatgata aatccagtga    360

caagcagctg cgtattaaac atgttagaag ggtcagaggg agagaagtta gtccatcaga    420

tgtgagagaa gactccaacc ttgagtcatc tcagttgact gttcaagcag aatttgatat    480

gtctgccata cctagaaaac gtggtagacc aagaaaaatc aatccatctg aagatgtagg    540

atctaaggct gttaaggaag agagaagccc caagaagaaa gaagctccca gcattagaag    600

gagatctaca agaaataccc cagctaaaag tgaaaatgtt gatgttggaa aaccagcttt    660

aggaaaatcc attttagtgc caaacgagga actttcgatg gtgatgagct ctaagaaaaa    720

acttacaaaa aagactgaaa gtcaaagcca aaaacgttca ttgcactcag tatcagaaga    780

acgcacagat gaaatgacac ataaagaaac aaatgagcag gaagaaagat tgctcgccac    840

agcttccttc actaaatcat cccgcagcag caggactcgg tctagcaagg ccatcttgtt    900

gccggacctt tctgaaccaa acaatgagcc tttattttct ccagcgtcag aagttccaag    960

gaaagcaaaa gaaagatgat gcacaatcag tagaaactct gggaaagcca aaagcgaaac   1020

gaatcaggac gtcaaaaaca aaacaagcaa gcaaaaacac agaaaaagaa agtgcttggt   1080

cacctcctcc catagaaatt cggctgattt cccccttggc tagcccagct gacggagtca   1140

agagcaaacc aagaaaaact acagaagtga caggaacagg tcttggaagg aacagaaaga   1200

aactgtcttc ctatccaaag caaattttac gcagaaaaat gctgtaattt cttgggaaga   1260

ttttaatgta cacctatttg taaagtcatc agaatagtgt ggattattaa atatctagtt   1320

tggaagaaaa taatttatat aaattattgt aaatttttat gtaaacagaa ggtcttcaat   1380

aagtaaagta actccatatg gagtgattgt ttcagtccag gcaatttttc tattttatat   1440

taagacttca tacatttata tatgtaaata tggcttatta atggaatgtt aaataaaatg   1500

tatacttcac agtcgtttgt gtcttggatt tttgaaaggg aggggatatc tgtttaaata   1560

gttttatatg ctcattggtc tcattttctc tataattaaa atactagacc agtcttaaaa   1620

tggggatgat tgaagtattg atatttcttt ttacagttac tattttataa tttatgcact   1680

ttgattctgt gattcagatt tctaatcaga aaatgtattt ttttgttttt ggctgttact   1740

atgttaaaat tgaattatgg gcatgtcatt ttgccatctt tgtagtttca caaattttgt   1800

gtaatctacc tcaaatgaat aatccaagta ttggttaact ataatgttgg catctcttat   1860

tcggcaagct taaaggctct ttaaagtctt aattagtcaa agactaatcc aggttagatt   1920

gaccggttca ctgctcactt gcaaccttat caaagggttt gacaaaggga aatgtaaaat   1980

aaatctgttt atggatattg agtgcatctt gtatgtgcct aatattgata ggatgagatg   2040

tctgaacaaa tttttataat attgctgtga aggagcttgc tattgaacca cagaaatccc   2100

ttaatattca ggttttaaaa ctggcaaatt ctcacaggac ctcaggcaca gattattgag   2160

gttgggagag agtgagtaga tgtagaaaag gagaaaaaca acacacgccc tgttctctac   2220

agtacaactg tgtgcaatta agcaatggta cttgatgtag gctctaacac tcatcaataa   2280

ataagtgttg taaaataatt tataacaggt aatcgatagt gtgtaatgaa tggactatta   2340

ataattgatt atctagaaac gaactgcttt cgtgggcttt taatatttta atgtgaagca   2400

tatgcagtgt gctttctgca tttatttttc taccaaataa tacagataat gagaaattgg   2460

tgaaaatgcc tacgcaaagt gttgacagtg tgaaagcagt gcgagtgcgg ccttttagtc   2520

aggttagtga tggatgttac gctgccttgt tgaaaatttc actgactttg attttattac   2580

ttttttaatg atagttatca aacttgtatt taagctgctt gtcatttatg gaatattgaa   2640

cttatttaaa tgaacttgtt aaatgaataa agagctaaac ataattcagt aaacaattcc   2700

tttgcgcaag tagcacaata aacatggatg caacgtatgt caagttaata cttttttaaa   2760

ccaacgcaat ttggtgaata tagatgtgtg gtacctgttt ttaataagtg tacttttttt   2820

cccccctccg tgaatgtaga tcataagcaa acaaattgcc tgttctaaat gaactttaca   2880

tatattttaa atgaatgtat gtacttacgt ataaatgtct ttatatagct tgaataaaaa   2940

cactgctcat taaaatgtgt tgctacaac                                     2969


<210>  2155
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  2155

Met Ile Arg Lys Leu Arg Ser Thr Asn Leu Asp Ala Ser Glu Asn Thr 
1               5                   10                  15


Gly Asn Lys Gln Asp Asp Lys Ser Ser Asp Lys Gln Leu Arg Ile Lys 
            20                  25                  30


His Val Arg Arg Val Arg Gly Arg Glu Val Ser Pro Ser Asp Val Arg 
        35                  40                  45


Glu Asp Ser Asn Leu Glu Ser Ser Gln Leu Thr Val Gln Ala Glu Phe 
    50                  55                  60


Asp Met Ser Ala Ile Pro Arg Lys Arg Gly Arg Pro Arg Lys Ile Asn 
65                  70                  75                  80


Pro Ser Glu Asp Val Gly Ser Lys Ala Val Lys Glu Glu Arg Ser Pro 
                85                  90                  95


Lys Lys Lys Glu Ala Pro Ser Ile Arg Arg Arg Ser Thr Arg Asn Thr 
            100                 105                 110


Pro Ala Lys Ser Glu Asn Val Asp Val Gly Lys Pro Ala Leu Gly Lys 
        115                 120                 125


Ser Ile Leu Val Pro Asn Glu Glu Leu Ser Met Val Met Ser Ser Lys 
    130                 135                 140


Lys Lys Leu Thr Lys Lys Thr Glu Ser Gln Ser Gln Lys Arg Ser Leu 
145                 150                 155                 160


His Ser Val Ser Glu Glu Arg Thr Asp Glu Met Thr His Lys Glu Thr 
                165                 170                 175


Asn Glu Gln Glu Glu Arg Leu Leu Ala Thr Ala Ser Phe Thr Lys Ser 
            180                 185                 190


Ser Arg Ser Ser Arg Thr Arg Ser Ser Lys Ala Ile Leu Leu Pro Asp 
        195                 200                 205


Leu Ser Glu Pro Asn Asn Glu Pro Leu Phe Ser Pro Ala Ser Glu Val 
    210                 215                 220


Pro Arg Lys Ala Lys Glu Arg 
225                 230


<210>  2156
<211>  2951
<212>  DNA
<213>  Homo sapiens

<400>  2156
tacgcctagg agaggaagga gaaagaaaga agttaatcag gacatactag aaaacaccag     60

ttctgtggaa caagaattac agatcactac aggtagggaa tcaaaaagat taaaatcatc    120

tcagctgttg gaaccagcag ttgaagaaac tactaaaaaa gaagttaagg tttcatctgt    180

tacaaaaagg actcctagaa gaattaaaag atctgtagaa aatcaggaaa gtgttgaaat    240

tataaatgat ctaaaagtta gtacggtaac aagtcctagc agaatgatca gaaaattgag    300

aagtactaat ttagatgctt ctgaaaatac aggaaataag caagatgata aatccagtga    360

caagcagctg cgtattaaac atgttagaag ggtcagaggg agagaagtta gtccatcaga    420

tgtgagagaa gactccaacc ttgagtcatc tcagttgact gttcaagcag aatttgatat    480

gtctgccata cctagaaaac gtggtagacc aagaaaaatc aatccatctg aagatgtagg    540

atctaaggct gttaaggaag agagaagccc caagaagaaa gaagctccca gcattagaag    600

gagatctaca agaaataccc cagctaaaag tgaaaatgtt gatgttggaa aaccagcttt    660

aggaaaatcc attttagtgc caaacgagga actttcgatg gtgatgagct ctaagaaaaa    720

acttacaaaa aagactgaaa gtcaaagcca aaaacgttca ttgcactcag tatcagaaga    780

acgcacagat gaaatgacac ataaagaaac aaatgagcag gaagaaagat tgctcgccac    840

agcttccttc actaaatcat cccgcagcag caggactcgg tctagcaagg ccatcttgtt    900

gccggacctt tctgaaccaa acaatgagcc tttattttct ccagcgtcag aagttccaag    960

gaaagcaaaa gaaagatgat gcacaatcag tagaaactct gggaaagcca aaagcgaaac   1020

gaatcaggac gtcaaaaaca aaacaagcaa gcaaaaacac agaaaaagaa agtgcttggt   1080

cacctcctcc catagaaatt cggctgattt cccccttggc tagcccagct gacggagtca   1140

agagcaaacc aagaaaaact acagaagtga caggaacagg tcttggaagg aacagaaaga   1200

aactgtcttc ctatccaaag caaattttac gcagaaaaat gctgtaattt cttgggaaga   1260

ttttaatgta cacctatttg taaagtcatc agaatagtgt ggattattaa atatctagtt   1320

tggaagaaaa taatttatat aaattattgt aaatttttat gtaaacagaa ggtcttcaat   1380

aagtaaagta actccatatg gagtgattgt ttcagtccag gcaatttttc tattttatat   1440

taagacttca tacatttata tatgtaaata tggcttatta atggaatgtt aaataaaatg   1500

tatacttcac agtcgtttgt gtcttggatt tttgaaaggg aggggatatc tgtttaaata   1560

gttttatatg ctcattggtc tcattttctc tataattaaa atactagacc agtcttaaaa   1620

tggggatgat tgaagtattg atatttcttt ttacagttac tattttataa tttatgcact   1680

ttgattctgt gattcagatt tctaatcaga aaatgtattt ttttgttttt ggctgttact   1740

atgttaaaat tgaattatgg gcatgtcatt ttgccatctt tgtagtttca caaattttgt   1800

gtaatctacc tcaaatgaat aatccaagta ttggttaact ataatgttgg catctcttat   1860

tcggcaagct taaaggctct ttaaagtctt aattagtcaa agactaatcc aggttagatt   1920

gaccggttca ctgctcactt gcaaccttat caaagggttt gacaaaggga aatgtaaaat   1980

aaatctgttt atggatattg agtgcatctt gtatgtgcct aatattgata ggatgagatg   2040

tctgaacaaa tttttataat attgctgtga aggagcttgc tattgaacca cagaaatccc   2100

ttaatattca ggttttaaaa ctggcaaatt ctcacaggac ctcaggcaca gattattgag   2160

gttgggagag agtgagtaga tgtagaaaag gagaaaaaca acacacgccc tgttctctac   2220

agtacaactg tgtgcaatta agcaatggta cttgatgtag gctctaacac tcatcaataa   2280

ataagtgttg taaaataatt tataacaggt aatcgatagt gtgtaatgaa tggactatta   2340

ataattgatt atctagaaac gaactgcttt cgtgggcttt taatatttta atgtgaagca   2400

tatgcagtgt gctttctgca tttatttttc taccaaataa tacagataat gagaaattgg   2460

tgaaaatgcc tacgcaaagt gttgacagtg tgaaagcagt gcgagtgcgg ccttttagtc   2520

aggttagtga tggatgttac gctgccttgt tgaaaatttc actgactttg attttattac   2580

ttttttaatg atagttatca aacttgtatt taagctgctt gtcatttatg gaatattgaa   2640

cttatttaaa tgaacttgtt aaatgaataa agagctaaac ataattcagt aaacaattcc   2700

tttgcgcaag tagcacaata aacatggatg caacgtatgt caagttaata cttttttaaa   2760

ccaacgcaat ttggtgaata tagatgtgtg gtacctgttt ttaataagtg tacttttttt   2820

cccccctccg tgaatgtaga tcataagcaa acaaattgcc tgttctaaat gaactttaca   2880

tatattttaa atgaatgtat gtacttacgt ataaatgtct ttatatagct tgaataaaaa   2940

cactgctcat t                                                        2951


<210>  2157
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  2157

Met Ile Arg Lys Leu Arg Ser Thr Asn Leu Asp Ala Ser Glu Asn Thr 
1               5                   10                  15


Gly Asn Lys Gln Asp Asp Lys Ser Ser Asp Lys Gln Leu Arg Ile Lys 
            20                  25                  30


His Val Arg Arg Val Arg Gly Arg Glu Val Ser Pro Ser Asp Val Arg 
        35                  40                  45


Glu Asp Ser Asn Leu Glu Ser Ser Gln Leu Thr Val Gln Ala Glu Phe 
    50                  55                  60


Asp Met Ser Ala Ile Pro Arg Lys Arg Gly Arg Pro Arg Lys Ile Asn 
65                  70                  75                  80


Pro Ser Glu Asp Val Gly Ser Lys Ala Val Lys Glu Glu Arg Ser Pro 
                85                  90                  95


Lys Lys Lys Glu Ala Pro Ser Ile Arg Arg Arg Ser Thr Arg Asn Thr 
            100                 105                 110


Pro Ala Lys Ser Glu Asn Val Asp Val Gly Lys Pro Ala Leu Gly Lys 
        115                 120                 125


Ser Ile Leu Val Pro Asn Glu Glu Leu Ser Met Val Met Ser Ser Lys 
    130                 135                 140


Lys Lys Leu Thr Lys Lys Thr Glu Ser Gln Ser Gln Lys Arg Ser Leu 
145                 150                 155                 160


His Ser Val Ser Glu Glu Arg Thr Asp Glu Met Thr His Lys Glu Thr 
                165                 170                 175


Asn Glu Gln Glu Glu Arg Leu Leu Ala Thr Ala Ser Phe Thr Lys Ser 
            180                 185                 190


Ser Arg Ser Ser Arg Thr Arg Ser Ser Lys Ala Ile Leu Leu Pro Asp 
        195                 200                 205


Leu Ser Glu Pro Asn Asn Glu Pro Leu Phe Ser Pro Ala Ser Glu Val 
    210                 215                 220


Pro Arg Lys Ala Lys Glu Arg 
225                 230


<210>  2158
<211>  8742
<212>  DNA
<213>  Homo sapiens

<400>  2158
acataatctc ggaccggagg agcggcggca catggcggcg gagcggcgct ggtggttcgc     60

gtcctgcgcc ggcagtcggg tccctttacg gacggccggg gccgcgaccc tttcccactg    120

ttctcccacg cgatggactc gttggcgggc ctttccccga gggaagcggc cggcgtgctg    180

agcctgtcct gtgttggcgt gtgttccaca tgcgcttggg cctggccaca tggaagtatg    240

cgagacttaa gagctcaagt gactagtggt ctcctgccat ttccagaagt gactcttcaa    300

gcccttggag aagacgaaat aacattagaa tctgtgcttc gtggaaagtt tgctgcaggg    360

aaaaatggac ttgcttgctt ggcttgtggt ccacaacttg aggtagtaaa ctctataaca    420

ggagagcgat tgtctgctta cagattcagt ggagtcaatg aacagcctcc tgtagtttta    480

gctgtgaaag aattctcttg gcagaagaga actggattat taataggatt ggaagaaaca    540

gaagggagtg ttctctgtct ttatgacctt ggaatatcaa aagtagttaa agcagttgtt    600

cttcctggaa gggtaacagc tattgaacct ataattaatc atggaggagc cagtgcaagc    660

actcagcatt tacatccaag tctgcgatgg ctttttggag tggcagctgt ggtcactgat    720

gttggacaga tccttcttgt tgacctatgt ttggatgact tgtcatgcaa tcaaaatgaa    780

gttgaagcat cagatcttga agttctaact ggtatcccag ctgaagtacc acacattaga    840

gaaagtgtaa tgagacaagg gcgccatctg tgtttccagt tagtaagtcc aacaggaaca    900

gctgtttcaa ctcttagtta cataagcagg acaaatcagc ttgctgtagg tttttctgat    960

ggctatctag cactttggaa catgaaaagc atgaaaagag aatattacat acaattggaa   1020

agtggacaag ttcctgtata tgctgtcact tttcaagaac ctgagaatga tcctcggaat   1080

tgctgttact tgtgggctgt tcagtctaca caagatagtg aaggggatgt tttgagtttg   1140

catctgctgc agctggcctt tggtaataga aagtgtttgg catcaggaca aatcttatat   1200

gaggggttag aatactgtga agaaagatac accctggacc tgacaggtgg catgttccct   1260

ttgaggggac agacgagtaa taccaaattg ttgggatgcc agagtataga gaaatttcga   1320

tctcatggtg acagggagga aggcgtgaat gaagctctat cgcctgacac tagtgtttca   1380

gtctttacct ggcaggtgaa tatatatgga cagggaaagc cttctgtata tttggggctt   1440

tttgatataa atcgttggta tcatgcacaa atgccagatt cgttaaggtc aggagaatat   1500

ctacataatt gctcttattt tgcactgtgg tcattggagt ctgttgtaag taggacttct   1560

ccacatggca tcttggatat attagtacat gagagaagtt taaatagagg agtccctcct   1620

tcatatccac ctcccgagca gttttttaat ccaagcactt ataattttga tgccacttgt   1680

ttgttaaact cgggagttgt tcatttaact tgtactggct ttcagaagga gactttgact   1740

tttttaaaga aatcaggtcc atcactcaat gaactcattc ctgatggtta taatcgatgt   1800

cttgtagctg gccttctttc cccaagattt gttgatgttc agccttccag tttaagccaa   1860

gaagaacagt tagaagctat attgtcagca gcaattcaga ctagttccct gggacttttg   1920

actggttata tccgaagatg gataacagaa gaacaaccaa attctgccac taatttgcgc   1980

tttgttcttg aatggacgtg gaataaagtg gttctcacaa aagaggaatt tgacagacta   2040

tgtgtgccat tatttgatgg ttcgtgtcat ttcatggatc cacaaactat acagtctatc   2100

cagcaatgct atttgcttct tagcaatctt aatatagtct tgagctgttt tgcatcagaa   2160

gcccgagaga tcactgagag aggactgata gacttaagca ataagtttgt ggtttcccac   2220

ctcatctgtc agtatgcaca agtggttctt tggttctctc attctgggct tttaccagaa   2280

ggcatagatg attctgtgca gttgtcaagg ttatgctaca actaccctgt aattcagaac   2340

tactacacca gtcgtcgaca gaagtttgag cgtttatcaa gagggaagtg gaatcccgat   2400

tgcttgatga ttgatggact ggtttctcag ttaggagagc gaattgagaa gttgtggaaa   2460

cgagatgaag gaggcacagg aaaatatcct cctgctagtc tgcatgcagt acttgatatg   2520

tacctattag acggcgttac tgaagcagcc aaacactcta ttaccattta tttgctactt   2580

gatattatgt attcctttcc caacaaaaca gacactccca ttgaatcttt cccaactgta   2640

tttgccattt cttggggcca agttaaactt attcaggggt tttggttgat agatcataat   2700

gactatgaga gtggtttgga tcttttgttt catccagcta ctgcaaaacc tttgtcatgg   2760

caacattcaa agattattca ggcattcatg agtcagggcg agcacagaca agccctcaga   2820

tatattcaga caatgaagcc aacagtgtcc agtggtaacg atgttatcct tcacctcact   2880

gttttgcttt ttaataggtg tatggttgaa gcctggaatt ttttgcggca acattgcaat   2940

aggttgaata tagaggagtt actgaagcac atgtatgaag tctgtcagga aatgggcttg   3000

atggaagatt tactgaagtt accatttaca gacactgagc aggaatgttt agtgaaattt   3060

ttgcagtcca gtgccagcgt tcagaatcat gaattccttt tagtgcacca tttgcagcgt   3120

gccaattatg tgcctgcctt gaagctgaac caaactctga agattaatgt tatgaatgat   3180

cgtgatcctc gtttgcggga gagatcactg gctcgaaatt ctatattaga ccagtatgga   3240

aaaatccttc ctagagtcca tcgaaaatta gccattgaac gagctaagcc ttatcatctg   3300

tcaacatcat cagtttttcg attagtttct agacccaaac cattatcagc agttccaaag   3360

caagttgtaa caggaactgt gttgacaaga tctgttttca tcaacaatgt gttatctaaa   3420

attggagaag tttgggcaag caaagaacct ataaatagca ccacaccttt caatagttct   3480

aaaatagaag aaccatctcc tatagtgtat tcgctcccag ctccagagct gcctgaggca   3540

ttttttggaa caccaatttc aaaagcatca caaaaaattt ctagactgct agatttggtt   3600

gttcagcctg tcccccggcc ttctcagtgt tcggagttta ttcagcaaag ctccatgaaa   3660

tctcctttgt acctagtatc ccgttcactg ccctcaagtt cgcaattaaa aggatcgcct   3720

caggccatct ccagggcttc agaattacat ttgcttgaaa ctcctcttgt agttaagaaa   3780

gctaaaagtt tggccatgtc agttactact tctggatttt ctgagttcac tcctcagtcc   3840

atcctgaggt ctactcttcg atcaacacct ttagcatctc cctctccatc acctggaagg   3900

tctcctcaac gacttaaaga aactagaatt tcatttgtgg aagaagatgt ccacccaaaa   3960

tggattcctg gggctgcaga tgatagcaaa ttagaagtat ttactacacc taaaaaatgt   4020

gcagttccag tggaaactga atggctgaag agcaaagata ggaccacatc ttttttcctg   4080

aacagccctg aaaaggagca tcaagaaatg gatgaggggt cacaaagttt agagaaactg   4140

gatgtgagca aaggaaacag cagtgtttca atcacatccg atgagactac cttagagtat   4200

caggatgcac cgtcaccgga agaccttgaa gagactgttt tcacggcctc taagcccaaa   4260

agctcttcca ctgcactaac tactaatgta actgaacaaa ctgaaaagga tggagataaa   4320

gatgtatttg catcagaagt aactccttca gacctacaga aacaaatggg caatttagaa   4380

gatgcagaaa caaaggatct cttagttgca gcagaggcat tttcagaatt gaatcactta   4440

agcccggttc aaggaactga agcttctctt tgtgcaccat cagtctatga agggaaaatc   4500

ttcacccaga agtccaaggt accagtgttg gacgaaggat taacatctgt tgaaacctac   4560

acccctgcaa ttagagcaaa tgacaataaa tctatggctg atgtccttgg tgatggtgga   4620

aactcctcgc tcactatctc tgaaggtcct attgtctctg agcgcaggct taaccaggaa   4680

gtagcgctga acttaaaaga agatcatgaa gtagaagttg gtgtactaaa agaaagtgtt   4740

gacttaccag aagaaaagct tccaatttct gacagccctc ctgatactca agaaattcat   4800

gtgattgaac aagaaaagct tgaagctcaa gattcaggag aagaggctag gaatctttca   4860

tttaatgagt tatatccctc tggaacactt aagcttcagt acaattttga tactattgac   4920

caacagtttt gtgacttagc tgataacaaa gacactgctg aatgtgacat tgctgaagta   4980

gatggggaac tttttgtggc tcaaagcaac tttaccttga tattggaagg tgaagaagga   5040

gaagttgagc caggtgattt tgcatcatct gatgtgttac ctaaagcagc taacacagca   5100

actgaagaaa aacttgtatg cagtggggaa aatgataatc atggacaaat tgcaaatttg   5160

ccatctgccg taactagtga ccaaaagtcc caaaaagtag acactttacc atatgtgcct   5220

gaacctatta aagtagcaat tgcagaaaat ttactagatg taattaaaga cacaagaagt   5280

aaagaaatta cttcagatac aatggaacag tccattcatg aaacaatacc tttagtgagc   5340

caaaacataa tgtgtcccac taaattggtc aaatctgcat ttaagactgc tcaggaaaca   5400

agcacaatga ctatgaatgt cagccaggtt gatgacgtgg tttcctccaa aactcgtacg   5460

agaggtcaac gtatccaaaa cgtgaatgtc aaatcagcac aacaggaagc atcagcagat   5520

gttgctactc ctaagatgcc agggcagtca gtcaggaaga aaactaggaa ggcaaaagaa   5580

atttctgaag cttctgaaaa catctattct gatgtcagag gactatctca gaaccagcaa   5640

atacctcaaa attctgttac gcctaggaga ggaaggagaa agaaagaagt taatcaggac   5700

atactagaaa acaccagttc tgtggaacaa gaattacaga tcactacagg tagggaatca   5760

aaaagattaa aatcatctca gctgttggaa ccagcagttg aagaaactac taaaaaagaa   5820

gttaaggttt catctgttac aaaaaggact cctagaagaa ttaaaagatc tgtagaaaat   5880

caggaaagtg ttgaaattat aaatgatcta aaagttagta cggtaacaag tcctagcaga   5940

atgatcagaa aattgagaag tactaattta gatgcttctg aaaatacagg aaataagcaa   6000

gatgataaat ccagtgacaa gcagctgcgt attaaacatg ttagaagggt cagagggaga   6060

gaagttagtc catcagatgt gagagaagac tccaaccttg agtcatctca gttgactgtt   6120

caagcagaat ttgatatgtc tgccatacct agaaaacgtg gtagaccaag aaaaatcaat   6180

ccatctgaag atgtaggatc taaggctgtt aaggaagaga gaagccccaa gaagaaagaa   6240

gctcccagca ttagaaggag atctacaaga aataccccag ctaaaagtga aaatgttgat   6300

gttggaaaac cagctttagg aaaatccatt ttagtgccaa acgaggaact ttcgatggtg   6360

atgagctcta agaaaaaact tacaaaaaag actgaaagtc aaagccaaaa acgttcattg   6420

cactcagtat cagaagaacg cacagatgaa atgacacata aagaaacaaa tgagcaggaa   6480

gaaagattgc tcgccacagc ttccttcact aaatcatccc gcagcagcag gactcggtct   6540

agcaaggcca tcttgttgcc ggacctttct gaaccaaaca atgagccttt attttctcca   6600

gcgtcagaag ttccaaggaa agcaaaagct aaaaaaatag aggttcctgc acagctgaaa   6660

gaattagttt cggatttatc ttctcagttt gtcatctcac ctcctgcttt aaggagcaga   6720

caaaaaaaca catccaataa gaacaagctt gaagatgaac tgaaagatga tgcacaatca   6780

gtagaaactc tgggaaagcc aaaagcgaaa cgaatcagga cgtcaaaaac aaaacaagca   6840

agcaaaaaca cagaaaaaga aagtgcttgg tcacctcctc ccatagaaat tcggctgatt   6900

tcccccttgg ctagcccagc tgacggagtc aagagcaaac caagaaaaac tacagaagtg   6960

acaggaacag gtcttggaag gaacagaaag aaactgtctt cctatccaaa gcaaatttta   7020

cgcagaaaaa tgctgtaatt tcttgggaag attttaatgt acacctattt gtaaagtcat   7080

cagaatagtg tggattatta aatatctagt ttggaagaaa ataatttata taaattattg   7140

taaattttta tgtaaacaga aggtcttcaa taagtaaagt aactccatat ggagtgattg   7200

tttcagtcca ggcaattttt ctattttata ttaagacttc atacatttat atatgtaaat   7260

atggcttatt aatggaatgt taaataaaat gtatacttca cagtcgtttg tgtcttggat   7320

ttttgaaagg gaggggatat ctgtttaaat agttttatat gctcattggt ctcattttct   7380

ctataattaa aatactagac cagtcttaaa atggggatga ttgaagtatt gatatttctt   7440

tttacagtta ctattttata atttatgcac tttgattctg tgattcagat ttctaatcag   7500

aaaatgtatt tttttgtttt tggctgttac tatgttaaaa ttgaattatg ggcatgtcat   7560

tttgccatct ttgtagtttc acaaattttg tgtaatctac ctcaaatgaa taatccaagt   7620

attggttaac tataatgttg gcatctctta ttcggcaagc ttaaaggctc tttaaagtct   7680

taattagtca aagactaatc caggttagat tgaccggttc actgctcact tgcaacctta   7740

tcaaagggtt tgacaaaggg aaatgtaaaa taaatctgtt tatggatatt gagtgcatct   7800

tgtatgtgcc taatattgat aggatgagat gtctgaacaa atttttataa tattgctgtg   7860

aaggagcttg ctattgaacc acagaaatcc cttaatattc aggttttaaa actggcaaat   7920

tctcacagga cctcaggcac agattattga ggttgggaga gagtgagtag atgtagaaaa   7980

ggagaaaaac aacacacgcc ctgttctcta cagtacaact gtgtgcaatt aagcaatggt   8040

acttgatgta ggctctaaca ctcatcaata aataagtgtt gtaaaataat ttataacagg   8100

taatcgatag tgtgtaatga atggactatt aataattgat tatctagaaa cgaactgctt   8160

tcgtgggctt ttaatatttt aatgtgaagc atatgcagtg tgctttctgc atttattttt   8220

ctaccaaata atacagataa tgagaaattg gtgaaaatgc ctacgcaaag tgttgacagt   8280

gtgaaagcag tgcgagtgcg gccttttagt caggttagtg atggatgtta cgctgccttg   8340

ttgaaaattt cactgacttt gattttatta cttttttaat gatagttatc aaacttgtat   8400

ttaagctgct tgtcatttat ggaatattga acttatttaa atgaacttgt taaatgaata   8460

aagagctaaa cataattcag taaacaattc ctttgcgcaa gtagcacaat aaacatggat   8520

gcaacgtatg tcaagttaat acttttttaa accaacgcaa tttggtgaat atagatgtgt   8580

ggtacctgtt tttaataagt gtactttttt tcccccctcc gtgaatgtag atcataagca   8640

aacaaattgc ctgttctaaa tgaactttac atatatttta aatgaatgta tgtacttacg   8700

tataaatgtc tttatatagc ttgaataaaa acactgctca tt                      8742


<210>  2159
<211>  2301
<212>  PRT
<213>  Homo sapiens

<400>  2159

Met Asp Ser Leu Ala Gly Leu Ser Pro Arg Glu Ala Ala Gly Val Leu 
1               5                   10                  15


Ser Leu Ser Cys Val Gly Val Cys Ser Thr Cys Ala Trp Ala Trp Pro 
            20                  25                  30


His Gly Ser Met Arg Asp Leu Arg Ala Gln Val Thr Ser Gly Leu Leu 
        35                  40                  45


Pro Phe Pro Glu Val Thr Leu Gln Ala Leu Gly Glu Asp Glu Ile Thr 
    50                  55                  60


Leu Glu Ser Val Leu Arg Gly Lys Phe Ala Ala Gly Lys Asn Gly Leu 
65                  70                  75                  80


Ala Cys Leu Ala Cys Gly Pro Gln Leu Glu Val Val Asn Ser Ile Thr 
                85                  90                  95


Gly Glu Arg Leu Ser Ala Tyr Arg Phe Ser Gly Val Asn Glu Gln Pro 
            100                 105                 110


Pro Val Val Leu Ala Val Lys Glu Phe Ser Trp Gln Lys Arg Thr Gly 
        115                 120                 125


Leu Leu Ile Gly Leu Glu Glu Thr Glu Gly Ser Val Leu Cys Leu Tyr 
    130                 135                 140


Asp Leu Gly Ile Ser Lys Val Val Lys Ala Val Val Leu Pro Gly Arg 
145                 150                 155                 160


Val Thr Ala Ile Glu Pro Ile Ile Asn His Gly Gly Ala Ser Ala Ser 
                165                 170                 175


Thr Gln His Leu His Pro Ser Leu Arg Trp Leu Phe Gly Val Ala Ala 
            180                 185                 190


Val Val Thr Asp Val Gly Gln Ile Leu Leu Val Asp Leu Cys Leu Asp 
        195                 200                 205


Asp Leu Ser Cys Asn Gln Asn Glu Val Glu Ala Ser Asp Leu Glu Val 
    210                 215                 220


Leu Thr Gly Ile Pro Ala Glu Val Pro His Ile Arg Glu Ser Val Met 
225                 230                 235                 240


Arg Gln Gly Arg His Leu Cys Phe Gln Leu Val Ser Pro Thr Gly Thr 
                245                 250                 255


Ala Val Ser Thr Leu Ser Tyr Ile Ser Arg Thr Asn Gln Leu Ala Val 
            260                 265                 270


Gly Phe Ser Asp Gly Tyr Leu Ala Leu Trp Asn Met Lys Ser Met Lys 
        275                 280                 285


Arg Glu Tyr Tyr Ile Gln Leu Glu Ser Gly Gln Val Pro Val Tyr Ala 
    290                 295                 300


Val Thr Phe Gln Glu Pro Glu Asn Asp Pro Arg Asn Cys Cys Tyr Leu 
305                 310                 315                 320


Trp Ala Val Gln Ser Thr Gln Asp Ser Glu Gly Asp Val Leu Ser Leu 
                325                 330                 335


His Leu Leu Gln Leu Ala Phe Gly Asn Arg Lys Cys Leu Ala Ser Gly 
            340                 345                 350


Gln Ile Leu Tyr Glu Gly Leu Glu Tyr Cys Glu Glu Arg Tyr Thr Leu 
        355                 360                 365


Asp Leu Thr Gly Gly Met Phe Pro Leu Arg Gly Gln Thr Ser Asn Thr 
    370                 375                 380


Lys Leu Leu Gly Cys Gln Ser Ile Glu Lys Phe Arg Ser His Gly Asp 
385                 390                 395                 400


Arg Glu Glu Gly Val Asn Glu Ala Leu Ser Pro Asp Thr Ser Val Ser 
                405                 410                 415


Val Phe Thr Trp Gln Val Asn Ile Tyr Gly Gln Gly Lys Pro Ser Val 
            420                 425                 430


Tyr Leu Gly Leu Phe Asp Ile Asn Arg Trp Tyr His Ala Gln Met Pro 
        435                 440                 445


Asp Ser Leu Arg Ser Gly Glu Tyr Leu His Asn Cys Ser Tyr Phe Ala 
    450                 455                 460


Leu Trp Ser Leu Glu Ser Val Val Ser Arg Thr Ser Pro His Gly Ile 
465                 470                 475                 480


Leu Asp Ile Leu Val His Glu Arg Ser Leu Asn Arg Gly Val Pro Pro 
                485                 490                 495


Ser Tyr Pro Pro Pro Glu Gln Phe Phe Asn Pro Ser Thr Tyr Asn Phe 
            500                 505                 510


Asp Ala Thr Cys Leu Leu Asn Ser Gly Val Val His Leu Thr Cys Thr 
        515                 520                 525


Gly Phe Gln Lys Glu Thr Leu Thr Phe Leu Lys Lys Ser Gly Pro Ser 
    530                 535                 540


Leu Asn Glu Leu Ile Pro Asp Gly Tyr Asn Arg Cys Leu Val Ala Gly 
545                 550                 555                 560


Leu Leu Ser Pro Arg Phe Val Asp Val Gln Pro Ser Ser Leu Ser Gln 
                565                 570                 575


Glu Glu Gln Leu Glu Ala Ile Leu Ser Ala Ala Ile Gln Thr Ser Ser 
            580                 585                 590


Leu Gly Leu Leu Thr Gly Tyr Ile Arg Arg Trp Ile Thr Glu Glu Gln 
        595                 600                 605


Pro Asn Ser Ala Thr Asn Leu Arg Phe Val Leu Glu Trp Thr Trp Asn 
    610                 615                 620


Lys Val Val Leu Thr Lys Glu Glu Phe Asp Arg Leu Cys Val Pro Leu 
625                 630                 635                 640


Phe Asp Gly Ser Cys His Phe Met Asp Pro Gln Thr Ile Gln Ser Ile 
                645                 650                 655


Gln Gln Cys Tyr Leu Leu Leu Ser Asn Leu Asn Ile Val Leu Ser Cys 
            660                 665                 670


Phe Ala Ser Glu Ala Arg Glu Ile Thr Glu Arg Gly Leu Ile Asp Leu 
        675                 680                 685


Ser Asn Lys Phe Val Val Ser His Leu Ile Cys Gln Tyr Ala Gln Val 
    690                 695                 700


Val Leu Trp Phe Ser His Ser Gly Leu Leu Pro Glu Gly Ile Asp Asp 
705                 710                 715                 720


Ser Val Gln Leu Ser Arg Leu Cys Tyr Asn Tyr Pro Val Ile Gln Asn 
                725                 730                 735


Tyr Tyr Thr Ser Arg Arg Gln Lys Phe Glu Arg Leu Ser Arg Gly Lys 
            740                 745                 750


Trp Asn Pro Asp Cys Leu Met Ile Asp Gly Leu Val Ser Gln Leu Gly 
        755                 760                 765


Glu Arg Ile Glu Lys Leu Trp Lys Arg Asp Glu Gly Gly Thr Gly Lys 
    770                 775                 780


Tyr Pro Pro Ala Ser Leu His Ala Val Leu Asp Met Tyr Leu Leu Asp 
785                 790                 795                 800


Gly Val Thr Glu Ala Ala Lys His Ser Ile Thr Ile Tyr Leu Leu Leu 
                805                 810                 815


Asp Ile Met Tyr Ser Phe Pro Asn Lys Thr Asp Thr Pro Ile Glu Ser 
            820                 825                 830


Phe Pro Thr Val Phe Ala Ile Ser Trp Gly Gln Val Lys Leu Ile Gln 
        835                 840                 845


Gly Phe Trp Leu Ile Asp His Asn Asp Tyr Glu Ser Gly Leu Asp Leu 
    850                 855                 860


Leu Phe His Pro Ala Thr Ala Lys Pro Leu Ser Trp Gln His Ser Lys 
865                 870                 875                 880


Ile Ile Gln Ala Phe Met Ser Gln Gly Glu His Arg Gln Ala Leu Arg 
                885                 890                 895


Tyr Ile Gln Thr Met Lys Pro Thr Val Ser Ser Gly Asn Asp Val Ile 
            900                 905                 910


Leu His Leu Thr Val Leu Leu Phe Asn Arg Cys Met Val Glu Ala Trp 
        915                 920                 925


Asn Phe Leu Arg Gln His Cys Asn Arg Leu Asn Ile Glu Glu Leu Leu 
    930                 935                 940


Lys His Met Tyr Glu Val Cys Gln Glu Met Gly Leu Met Glu Asp Leu 
945                 950                 955                 960


Leu Lys Leu Pro Phe Thr Asp Thr Glu Gln Glu Cys Leu Val Lys Phe 
                965                 970                 975


Leu Gln Ser Ser Ala Ser Val Gln Asn His Glu Phe Leu Leu Val His 
            980                 985                 990


His Leu Gln Arg Ala Asn Tyr Val Pro Ala Leu Lys Leu Asn Gln Thr 
        995                 1000                1005


Leu Lys Ile Asn Val Met Asn Asp Arg Asp Pro Arg Leu Arg Glu Arg 
    1010                1015                1020


Ser Leu Ala Arg Asn Ser Ile Leu Asp Gln Tyr Gly Lys Ile Leu Pro 
1025                1030                1035                1040


Arg Val His Arg Lys Leu Ala Ile Glu Arg Ala Lys Pro Tyr His Leu 
                1045                1050                1055


Ser Thr Ser Ser Val Phe Arg Leu Val Ser Arg Pro Lys Pro Leu Ser 
            1060                1065                1070


Ala Val Pro Lys Gln Val Val Thr Gly Thr Val Leu Thr Arg Ser Val 
        1075                1080                1085


Phe Ile Asn Asn Val Leu Ser Lys Ile Gly Glu Val Trp Ala Ser Lys 
    1090                1095                1100


Glu Pro Ile Asn Ser Thr Thr Pro Phe Asn Ser Ser Lys Ile Glu Glu 
1105                1110                1115                1120


Pro Ser Pro Ile Val Tyr Ser Leu Pro Ala Pro Glu Leu Pro Glu Ala 
                1125                1130                1135


Phe Phe Gly Thr Pro Ile Ser Lys Ala Ser Gln Lys Ile Ser Arg Leu 
            1140                1145                1150


Leu Asp Leu Val Val Gln Pro Val Pro Arg Pro Ser Gln Cys Ser Glu 
        1155                1160                1165


Phe Ile Gln Gln Ser Ser Met Lys Ser Pro Leu Tyr Leu Val Ser Arg 
    1170                1175                1180


Ser Leu Pro Ser Ser Ser Gln Leu Lys Gly Ser Pro Gln Ala Ile Ser 
1185                1190                1195                1200


Arg Ala Ser Glu Leu His Leu Leu Glu Thr Pro Leu Val Val Lys Lys 
                1205                1210                1215


Ala Lys Ser Leu Ala Met Ser Val Thr Thr Ser Gly Phe Ser Glu Phe 
            1220                1225                1230


Thr Pro Gln Ser Ile Leu Arg Ser Thr Leu Arg Ser Thr Pro Leu Ala 
        1235                1240                1245


Ser Pro Ser Pro Ser Pro Gly Arg Ser Pro Gln Arg Leu Lys Glu Thr 
    1250                1255                1260


Arg Ile Ser Phe Val Glu Glu Asp Val His Pro Lys Trp Ile Pro Gly 
1265                1270                1275                1280


Ala Ala Asp Asp Ser Lys Leu Glu Val Phe Thr Thr Pro Lys Lys Cys 
                1285                1290                1295


Ala Val Pro Val Glu Thr Glu Trp Leu Lys Ser Lys Asp Arg Thr Thr 
            1300                1305                1310


Ser Phe Phe Leu Asn Ser Pro Glu Lys Glu His Gln Glu Met Asp Glu 
        1315                1320                1325


Gly Ser Gln Ser Leu Glu Lys Leu Asp Val Ser Lys Gly Asn Ser Ser 
    1330                1335                1340


Val Ser Ile Thr Ser Asp Glu Thr Thr Leu Glu Tyr Gln Asp Ala Pro 
1345                1350                1355                1360


Ser Pro Glu Asp Leu Glu Glu Thr Val Phe Thr Ala Ser Lys Pro Lys 
                1365                1370                1375


Ser Ser Ser Thr Ala Leu Thr Thr Asn Val Thr Glu Gln Thr Glu Lys 
            1380                1385                1390


Asp Gly Asp Lys Asp Val Phe Ala Ser Glu Val Thr Pro Ser Asp Leu 
        1395                1400                1405


Gln Lys Gln Met Gly Asn Leu Glu Asp Ala Glu Thr Lys Asp Leu Leu 
    1410                1415                1420


Val Ala Ala Glu Ala Phe Ser Glu Leu Asn His Leu Ser Pro Val Gln 
1425                1430                1435                1440


Gly Thr Glu Ala Ser Leu Cys Ala Pro Ser Val Tyr Glu Gly Lys Ile 
                1445                1450                1455


Phe Thr Gln Lys Ser Lys Val Pro Val Leu Asp Glu Gly Leu Thr Ser 
            1460                1465                1470


Val Glu Thr Tyr Thr Pro Ala Ile Arg Ala Asn Asp Asn Lys Ser Met 
        1475                1480                1485


Ala Asp Val Leu Gly Asp Gly Gly Asn Ser Ser Leu Thr Ile Ser Glu 
    1490                1495                1500


Gly Pro Ile Val Ser Glu Arg Arg Leu Asn Gln Glu Val Ala Leu Asn 
1505                1510                1515                1520


Leu Lys Glu Asp His Glu Val Glu Val Gly Val Leu Lys Glu Ser Val 
                1525                1530                1535


Asp Leu Pro Glu Glu Lys Leu Pro Ile Ser Asp Ser Pro Pro Asp Thr 
            1540                1545                1550


Gln Glu Ile His Val Ile Glu Gln Glu Lys Leu Glu Ala Gln Asp Ser 
        1555                1560                1565


Gly Glu Glu Ala Arg Asn Leu Ser Phe Asn Glu Leu Tyr Pro Ser Gly 
    1570                1575                1580


Thr Leu Lys Leu Gln Tyr Asn Phe Asp Thr Ile Asp Gln Gln Phe Cys 
1585                1590                1595                1600


Asp Leu Ala Asp Asn Lys Asp Thr Ala Glu Cys Asp Ile Ala Glu Val 
                1605                1610                1615


Asp Gly Glu Leu Phe Val Ala Gln Ser Asn Phe Thr Leu Ile Leu Glu 
            1620                1625                1630


Gly Glu Glu Gly Glu Val Glu Pro Gly Asp Phe Ala Ser Ser Asp Val 
        1635                1640                1645


Leu Pro Lys Ala Ala Asn Thr Ala Thr Glu Glu Lys Leu Val Cys Ser 
    1650                1655                1660


Gly Glu Asn Asp Asn His Gly Gln Ile Ala Asn Leu Pro Ser Ala Val 
1665                1670                1675                1680


Thr Ser Asp Gln Lys Ser Gln Lys Val Asp Thr Leu Pro Tyr Val Pro 
                1685                1690                1695


Glu Pro Ile Lys Val Ala Ile Ala Glu Asn Leu Leu Asp Val Ile Lys 
            1700                1705                1710


Asp Thr Arg Ser Lys Glu Ile Thr Ser Asp Thr Met Glu Gln Ser Ile 
        1715                1720                1725


His Glu Thr Ile Pro Leu Val Ser Gln Asn Ile Met Cys Pro Thr Lys 
    1730                1735                1740


Leu Val Lys Ser Ala Phe Lys Thr Ala Gln Glu Thr Ser Thr Met Thr 
1745                1750                1755                1760


Met Asn Val Ser Gln Val Asp Asp Val Val Ser Ser Lys Thr Arg Thr 
                1765                1770                1775


Arg Gly Gln Arg Ile Gln Asn Val Asn Val Lys Ser Ala Gln Gln Glu 
            1780                1785                1790


Ala Ser Ala Asp Val Ala Thr Pro Lys Met Pro Gly Gln Ser Val Arg 
        1795                1800                1805


Lys Lys Thr Arg Lys Ala Lys Glu Ile Ser Glu Ala Ser Glu Asn Ile 
    1810                1815                1820


Tyr Ser Asp Val Arg Gly Leu Ser Gln Asn Gln Gln Ile Pro Gln Asn 
1825                1830                1835                1840


Ser Val Thr Pro Arg Arg Gly Arg Arg Lys Lys Glu Val Asn Gln Asp 
                1845                1850                1855


Ile Leu Glu Asn Thr Ser Ser Val Glu Gln Glu Leu Gln Ile Thr Thr 
            1860                1865                1870


Gly Arg Glu Ser Lys Arg Leu Lys Ser Ser Gln Leu Leu Glu Pro Ala 
        1875                1880                1885


Val Glu Glu Thr Thr Lys Lys Glu Val Lys Val Ser Ser Val Thr Lys 
    1890                1895                1900


Arg Thr Pro Arg Arg Ile Lys Arg Ser Val Glu Asn Gln Glu Ser Val 
1905                1910                1915                1920


Glu Ile Ile Asn Asp Leu Lys Val Ser Thr Val Thr Ser Pro Ser Arg 
                1925                1930                1935


Met Ile Arg Lys Leu Arg Ser Thr Asn Leu Asp Ala Ser Glu Asn Thr 
            1940                1945                1950


Gly Asn Lys Gln Asp Asp Lys Ser Ser Asp Lys Gln Leu Arg Ile Lys 
        1955                1960                1965


His Val Arg Arg Val Arg Gly Arg Glu Val Ser Pro Ser Asp Val Arg 
    1970                1975                1980


Glu Asp Ser Asn Leu Glu Ser Ser Gln Leu Thr Val Gln Ala Glu Phe 
1985                1990                1995                2000


Asp Met Ser Ala Ile Pro Arg Lys Arg Gly Arg Pro Arg Lys Ile Asn 
                2005                2010                2015


Pro Ser Glu Asp Val Gly Ser Lys Ala Val Lys Glu Glu Arg Ser Pro 
            2020                2025                2030


Lys Lys Lys Glu Ala Pro Ser Ile Arg Arg Arg Ser Thr Arg Asn Thr 
        2035                2040                2045


Pro Ala Lys Ser Glu Asn Val Asp Val Gly Lys Pro Ala Leu Gly Lys 
    2050                2055                2060


Ser Ile Leu Val Pro Asn Glu Glu Leu Ser Met Val Met Ser Ser Lys 
2065                2070                2075                2080


Lys Lys Leu Thr Lys Lys Thr Glu Ser Gln Ser Gln Lys Arg Ser Leu 
                2085                2090                2095


His Ser Val Ser Glu Glu Arg Thr Asp Glu Met Thr His Lys Glu Thr 
            2100                2105                2110


Asn Glu Gln Glu Glu Arg Leu Leu Ala Thr Ala Ser Phe Thr Lys Ser 
        2115                2120                2125


Ser Arg Ser Ser Arg Thr Arg Ser Ser Lys Ala Ile Leu Leu Pro Asp 
    2130                2135                2140


Leu Ser Glu Pro Asn Asn Glu Pro Leu Phe Ser Pro Ala Ser Glu Val 
2145                2150                2155                2160


Pro Arg Lys Ala Lys Ala Lys Lys Ile Glu Val Pro Ala Gln Leu Lys 
                2165                2170                2175


Glu Leu Val Ser Asp Leu Ser Ser Gln Phe Val Ile Ser Pro Pro Ala 
            2180                2185                2190


Leu Arg Ser Arg Gln Lys Asn Thr Ser Asn Lys Asn Lys Leu Glu Asp 
        2195                2200                2205


Glu Leu Lys Asp Asp Ala Gln Ser Val Glu Thr Leu Gly Lys Pro Lys 
    2210                2215                2220


Ala Lys Arg Ile Arg Thr Ser Lys Thr Lys Gln Ala Ser Lys Asn Thr 
2225                2230                2235                2240


Glu Lys Glu Ser Ala Trp Ser Pro Pro Pro Ile Glu Ile Arg Leu Ile 
                2245                2250                2255


Ser Pro Leu Ala Ser Pro Ala Asp Gly Val Lys Ser Lys Pro Arg Lys 
            2260                2265                2270


Thr Thr Glu Val Thr Gly Thr Gly Leu Gly Arg Asn Arg Lys Lys Leu 
        2275                2280                2285


Ser Ser Tyr Pro Lys Gln Ile Leu Arg Arg Lys Met Leu 
    2290                2295                2300


<210>  2160
<211>  8913
<212>  DNA
<213>  Homo sapiens

<400>  2160
gctccctccc ttccggggcg tgtggaactc ggttttgtcg gcgcagggta atgcgcagag     60

cggggccggc gctgtccgag gcgagcaggc agcgttgcaa ggggaaggac ccagaagcgc    120

ggcgggagca gcgactgcgt tttagccgct gagcggtctg caggcctaca gcccgcgaag    180

gcactctcgg gggcgtgtgg ctctgaggtg gccggggagg tcgcaggcgg cggccggagc    240

gcagaggagc ggcttcagcc gggcggaggg gtgtgagccc ggcccgtggc ggccacgtct    300

cccgggagat gctgtgacgg acccgcacgg gaggagctcg cgcctggcct ggcgacccgg    360

tggactcggc ccgcggcggc gcgctcaccc gccccgttca gtggaagtat gcgagactta    420

agagctcaag tgactagtgg tctcctgcca tttccagaag tgactcttca agcccttgga    480

gaagacgaaa taacattaga atctgtgctt cgtggaaagt ttgctgcagg gaaaaatgga    540

cttgcttgct tggcttgtgg tccacaactt gaggtagtaa actctataac aggagagcga    600

ttgtctgctt acagattcag tggagtcaat gaacagcctc ctgtagtttt agctgtgaaa    660

gaattctctt ggcagaagag aactggatta ttaataggat tggaagaaac agaagggagt    720

gttctctgtc tttatgacct tggaatatca aaagtagtta aagcagttgt tcttcctgga    780

agggtaacag ctattgaacc tataattaat catggaggag ccagtgcaag cactcagcat    840

ttacatccaa gtctgcgatg gctttttgga gtggcagctg tggtcactga tgttggacag    900

atccttcttg ttgacctatg tttggatgac ttgtcatgca atcaaaatga agttgaagca    960

tcagatcttg aagttctaac tggtatccca gctgaagtac cacacattag agaaagtgta   1020

atgagacaag ggcgccatct gtgtttccag ttagtaagtc caacaggaac agctgtttca   1080

actcttagtt acataagcag gacaaatcag cttgctgtag gtttttctga tggctatcta   1140

gcactttgga acatgaaaag catgaaaaga gaatattaca tacaattgga aagtggacaa   1200

gttcctgtat atgctgtcac ttttcaagaa cctgagaatg atcctcggaa ttgctgttac   1260

ttgtgggctg ttcagtctac acaagatagt gaaggggatg ttttgagttt gcatctgctg   1320

cagctggcct ttggtaatag aaagtgtttg gcatcaggac aaatcttata tgaggggtta   1380

gaatactgtg aagaaagata caccctggac ctgacaggtg gcatgttccc tttgagggga   1440

cagacgagta ataccaaatt gttgggatgc cagagtatag agaaatttcg atctcatggt   1500

gacagggagg aaggcgtgaa tgaagctcta tcgcctgaca ctagtgtttc agtctttacc   1560

tggcaggtga atatatatgg acagggaaag ccttctgtat atttggggct ttttgatata   1620

aatcgttggt atcatgcaca aatgccagat tcgttaaggt caggagaata tctacataat   1680

tgctcttatt ttgcactgtg gtcattggag tctgttgtaa gtaggacttc tccacatggc   1740

atcttggata tattagtaca tgagagaagt ttaaatagag gagtccctcc ttcatatcca   1800

cctcccgagc agttttttaa tccaagcact tataattttg atgccacttg tttgttaaac   1860

tcgggagttg ttcatttaac ttgtactggc tttcagaagg agactttgac ttttttaaag   1920

aaatcaggtc catcactcaa tgaactcatt cctgatggtt ataatcgatg tcttgtagct   1980

ggccttcttt ccccaagatt tgttgatgtt cagccttcca gtttaagcca agaagaacag   2040

ttagaagcta tattgtcagc agcaattcag actagttccc tgggactttt gactggttat   2100

atccgaagat ggataacaga agaacaacca aattctgcca ctaatttgcg ctttgttctt   2160

gaatggacgt ggaataaagt ggttctcaca aaagaggaat ttgacagact atgtgtgcca   2220

ttatttgatg gttcgtgtca tttcatggat ccacaaacta tacagtctat ccagcaatgc   2280

tatttgcttc ttagcaatct taatatagtc ttgagctgtt ttgcatcaga agcccgagag   2340

atcactgaga gaggactgat agacttaagc aataagtttg tggtttccca cctcatctgt   2400

cagtatgcac aagtggttct ttggttctct cattctgggc ttttaccaga aggcatagat   2460

gattctgtgc agttgtcaag gttatgctac aactaccctg taattcagaa ctactacacc   2520

agtcgtcgac agaagtttga gcgtttatca agagggaagt ggaatcccga ttgcttgatg   2580

attgatggac tggtttctca gttaggagag cgaattgaga agttgtggaa acgagatgaa   2640

ggaggcacag gaaaatatcc tcctgctagt ctgcatgcag tacttgatat gtacctatta   2700

gacggcgtta ctgaagcagc caaacactct attaccattt atttgctact tgatattatg   2760

tattcctttc ccaacaaaac agacactccc attgaatctt tcccaactgt atttgccatt   2820

tcttggggcc aagttaaact tattcagggg ttttggttga tagatcataa tgactatgag   2880

agtggtttgg atcttttgtt tcatccagct actgcaaaac ctttgtcatg gcaacattca   2940

aagattattc aggcattcat gagtcagggc gagcacagac aagccctcag atatattcag   3000

acaatgaagc caacagtgtc cagtggtaac gatgttatcc ttcacctcac tgttttgctt   3060

tttaataggt gtatggttga agcctggaat tttttgcggc aacattgcaa taggttgaat   3120

atagaggagt tactgaagca catgtatgaa gtctgtcagg aaatgggctt gatggaagat   3180

ttactgaagt taccatttac agacactgag caggaatgtt tagtgaaatt tttgcagtcc   3240

agtgccagcg ttcagaatca tgaattcctt ttagtgcacc atttgcagcg tgccaattat   3300

gtgcctgcct tgaagctgaa ccaaactctg aagattaatg ttatgaatga tcgtgatcct   3360

cgtttgcggg agagatcact ggctcgaaat tctatattag accagtatgg aaaaatcctt   3420

cctagagtcc atcgaaaatt agccattgaa cgagctaagc cttatcatct gtcaacatca   3480

tcagtttttc gattagtttc tagacccaaa ccattatcag cagttccaaa gcaagttgta   3540

acaggaactg tgttgacaag atctgttttc atcaacaatg tgttatctaa aattggagaa   3600

gtttgggcaa gcaaagaacc tataaatagc accacacctt tcaatagttc taaaatagaa   3660

gaaccatctc ctatagtgta ttcgctccca gctccagagc tgcctgaggc attttttgga   3720

acaccaattt caaaagcatc acaaaaaatt tctagactgc tagatttggt tgttcagcct   3780

gtcccccggc cttctcagtg ttcggagttt attcagcaaa gctccatgaa atctcctttg   3840

tacctagtat cccgttcact gccctcaagt tcgcaattaa aaggatcgcc tcaggccatc   3900

tccagggctt cagaattaca tttgcttgaa actcctcttg tagttaagaa agctaaaagt   3960

ttggccatgt cagttactac ttctggattt tctgagttca ctcctcagtc catcctgagg   4020

tctactcttc gatcaacacc tttagcatct ccctctccat cacctggaag gtctcctcaa   4080

cgacttaaag aaactagaat ttcatttgtg gaagaagatg tccacccaaa atggattcct   4140

ggggctgcag atgatagcaa attagaagta tttactacac ctaaaaaatg tgcagttcca   4200

gtggaaactg aatggctgaa gagcaaagat aggaccacat cttttttcct gaacagccct   4260

gaaaaggagc atcaagaaat ggatgagggg tcacaaagtt tagagaaact ggatgtgagc   4320

aaaggaaaca gcagtgtttc aatcacatcc gatgagacta ccttagagta tcaggatgca   4380

ccgtcaccgg aagaccttga agagactgtt ttcacggcct ctaagcccaa aagctcttcc   4440

actgcactaa ctactaatgt aactgaacaa actgaaaagg atggagataa agatgtattt   4500

gcatcagaag taactccttc agacctacag aaacaaatgg gcaatttaga agatgcagaa   4560

acaaaggatc tcttagttgc agcagaggca ttttcagaat tgaatcactt aagcccggtt   4620

caaggaactg aagcttctct ttgtgcacca tcagtctatg aagggaaaat cttcacccag   4680

aagtccaagg taccagtgtt ggacgaagga ttaacatctg ttgaaaccta cacccctgca   4740

attagagcaa atgacaataa atctatggct gatgtccttg gtgatggtgg aaactcctcg   4800

ctcactatct ctgaaggtcc tattgtctct gagcgcaggc ttaaccagga agtagcgctg   4860

aacttaaaag aagatcatga agtagaagtt ggtgtactaa aagaaagtgt tgacttacca   4920

gaagaaaagc ttccaatttc tgacagccct cctgatactc aagaaattca tgtgattgaa   4980

caagaaaagc ttgaagctca agattcagga gaagaggcta ggaatctttc atttaatgag   5040

ttatatccct ctggaacact taagcttcag tacaattttg atactattga ccaacagttt   5100

tgtgacttag ctgataacaa agacactgct gaatgtgaca ttgctgaagt agatggggaa   5160

ctttttgtgg ctcaaagcaa ctttaccttg atattggaag gtgaagaagg agaagttgag   5220

ccaggtgatt ttgcatcatc tgatgtgtta cctaaagcag ctaacacagc aactgaagaa   5280

aaacttgtat gcagtgggga aaatgataat catggacaaa ttgcaaattt gccatctgcc   5340

gtaactagtg accaaaagtc ccaaaaagta gacactttac catatgtgcc tgaacctatt   5400

aaagtagcaa ttgcagaaaa tttactagat gtaattaaag acacaagaag taaagaaatt   5460

acttcagata caatggaaca gtccattcat gaaacaatac ctttagtgag ccaaaacata   5520

atgtgtccca ctaaattggt caaatctgca tttaagactg ctcaggaaac aagcacaatg   5580

actatgaatg tcagccaggt tgatgacgtg gtttcctcca aaactcgtac gagaggtcaa   5640

cgtatccaaa acgtgaatgt caaatcagca caacaggaag catcagcaga tgttgctact   5700

cctaagatgc cagggcagtc agtcaggaag aaaactagga aggcaaaaga aatttctgaa   5760

gcttctgaaa acatctattc tgatgtcaga ggactatctc agaaccagca aatacctcaa   5820

aattctgtta cgcctaggag aggaaggaga aagaaagaag ttaatcagga catactagaa   5880

aacaccagtt ctgtggaaca agaattacag atcactacag gtagggaatc aaaaagatta   5940

aaatcatctc agctgttgga accagcagtt gaagaaacta ctaaaaaaga agttaaggtt   6000

tcatctgtta caaaaaggac tcctagaaga attaaaagat ctgtagaaaa tcaggaaagt   6060

gttgaaatta taaatgatct aaaagttagt acggtaacaa gtcctagcag aatgatcaga   6120

aaattgagaa gtactaattt agatgcttct gaaaatacag gaaataagca agatgataaa   6180

tccagtgaca agcagctgcg tattaaacat gttagaaggg tcagagggag agaagttagt   6240

ccatcagatg tgagagaaga ctccaacctt gagtcatctc agttgactgt tcaagcagaa   6300

tttgatatgt ctgccatacc tagaaaacgt ggtagaccaa gaaaaatcaa tccatctgaa   6360

gatgtaggat ctaaggctgt taaggaagag agaagcccca agaagaaaga agctcccagc   6420

attagaagga gatctacaag aaatacccca gctaaaagtg aaaatgttga tgttggaaaa   6480

ccagctttag gaaaatccat tttagtgcca aacgaggaac tttcgatggt gatgagctct   6540

aagaaaaaac ttacaaaaaa gactgaaagt caaagccaaa aacgttcatt gcactcagta   6600

tcagaagaac gcacagatga aatgacacat aaagaaacaa atgagcagga agaaagattg   6660

ctcgccacag cttccttcac taaatcatcc cgcagcagca ggactcggtc tagcaaggcc   6720

atcttgttgc cggacctttc tgaaccaaac aatgagcctt tattttctcc agcgtcagaa   6780

gttccaagga aagcaaaagc taaaaaaata gaggttcctg cacagctgaa agaattagtt   6840

tcggatttat cttctcagtt tgtcatctca cctcctgctt taaggagcag acaaaaaaac   6900

acatccaata agaacaagct tgaagatgaa ctgaaagatg atgcacaatc agtagaaact   6960

ctgggaaagc caaaagcgaa acgaatcagg acgtcaaaaa caaaacaagc aagcaaaaac   7020

acagaaaaag aaagtgcttg gtcacctcct cccatagaaa ttcggctgat ttcccccttg   7080

gctagcccag ctgacggagt caagagcaaa ccaagaaaaa ctacagaagt gacaggaaca   7140

ggtcttggaa ggaacagaaa gaaactgtct tcctatccaa agcaaatttt acgcagaaaa   7200

atgctgtaat ttcttgggaa gattttaatg tacacctatt tgtaaagtca tcagaatagt   7260

gtggattatt aaatatctag tttggaagaa aataatttat ataaattatt gtaaattttt   7320

atgtaaacag aaggtcttca ataagtaaag taactccata tggagtgatt gtttcagtcc   7380

aggcaatttt tctattttat attaagactt catacattta tatatgtaaa tatggcttat   7440

taatggaatg ttaaataaaa tgtatacttc acagtcgttt gtgtcttgga tttttgaaag   7500

ggaggggata tctgtttaaa tagttttata tgctcattgg tctcattttc tctataatta   7560

aaatactaga ccagtcttaa aatggggatg attgaagtat tgatatttct ttttacagtt   7620

actattttat aatttatgca ctttgattct gtgattcaga tttctaatca gaaaatgtat   7680

ttttttgttt ttggctgtta ctatgttaaa attgaattat gggcatgtca ttttgccatc   7740

tttgtagttt cacaaatttt gtgtaatcta cctcaaatga ataatccaag tattggttaa   7800

ctataatgtt ggcatctctt attcggcaag cttaaaggct ctttaaagtc ttaattagtc   7860

aaagactaat ccaggttaga ttgaccggtt cactgctcac ttgcaacctt atcaaagggt   7920

ttgacaaagg gaaatgtaaa ataaatctgt ttatggatat tgagtgcatc ttgtatgtgc   7980

ctaatattga taggatgaga tgtctgaaca aatttttata atattgctgt gaaggagctt   8040

gctattgaac cacagaaatc ccttaatatt caggttttaa aactggcaaa ttctcacagg   8100

acctcaggca cagattattg aggttgggag agagtgagta gatgtagaaa aggagaaaaa   8160

caacacacgc cctgttctct acagtacaac tgtgtgcaat taagcaatgg tacttgatgt   8220

aggctctaac actcatcaat aaataagtgt tgtaaaataa tttataacag gtaatcgata   8280

gtgtgtaatg aatggactat taataattga ttatctagaa acgaactgct ttcgtgggct   8340

tttaatattt taatgtgaag catatgcagt gtgctttctg catttatttt tctaccaaat   8400

aatacagata atgagaaatt ggtgaaaatg cctacgcaaa gtgttgacag tgtgaaagca   8460

gtgcgagtgc ggccttttag tcaggttagt gatggatgtt acgctgcctt gttgaaaatt   8520

tcactgactt tgattttatt acttttttaa tgatagttat caaacttgta tttaagctgc   8580

ttgtcattta tggaatattg aacttattta aatgaacttg ttaaatgaat aaagagctaa   8640

acataattca gtaaacaatt cctttgcgca agtagcacaa taaacatgga tgcaacgtat   8700

gtcaagttaa tactttttta aaccaacgca atttggtgaa tatagatgtg tggtacctgt   8760

ttttaataag tgtacttttt ttcccccctc cgtgaatgta gatcataagc aaacaaattg   8820

cctgttctaa atgaacttta catatatttt aaatgaatgt atgtacttac gtataaatgt   8880

ctttatatag cttgaataaa aacactgctc att                                8913


<210>  2161
<211>  2266
<212>  PRT
<213>  Homo sapiens

<400>  2161

Met Arg Asp Leu Arg Ala Gln Val Thr Ser Gly Leu Leu Pro Phe Pro 
1               5                   10                  15


Glu Val Thr Leu Gln Ala Leu Gly Glu Asp Glu Ile Thr Leu Glu Ser 
            20                  25                  30


Val Leu Arg Gly Lys Phe Ala Ala Gly Lys Asn Gly Leu Ala Cys Leu 
        35                  40                  45


Ala Cys Gly Pro Gln Leu Glu Val Val Asn Ser Ile Thr Gly Glu Arg 
    50                  55                  60


Leu Ser Ala Tyr Arg Phe Ser Gly Val Asn Glu Gln Pro Pro Val Val 
65                  70                  75                  80


Leu Ala Val Lys Glu Phe Ser Trp Gln Lys Arg Thr Gly Leu Leu Ile 
                85                  90                  95


Gly Leu Glu Glu Thr Glu Gly Ser Val Leu Cys Leu Tyr Asp Leu Gly 
            100                 105                 110


Ile Ser Lys Val Val Lys Ala Val Val Leu Pro Gly Arg Val Thr Ala 
        115                 120                 125


Ile Glu Pro Ile Ile Asn His Gly Gly Ala Ser Ala Ser Thr Gln His 
    130                 135                 140


Leu His Pro Ser Leu Arg Trp Leu Phe Gly Val Ala Ala Val Val Thr 
145                 150                 155                 160


Asp Val Gly Gln Ile Leu Leu Val Asp Leu Cys Leu Asp Asp Leu Ser 
                165                 170                 175


Cys Asn Gln Asn Glu Val Glu Ala Ser Asp Leu Glu Val Leu Thr Gly 
            180                 185                 190


Ile Pro Ala Glu Val Pro His Ile Arg Glu Ser Val Met Arg Gln Gly 
        195                 200                 205


Arg His Leu Cys Phe Gln Leu Val Ser Pro Thr Gly Thr Ala Val Ser 
    210                 215                 220


Thr Leu Ser Tyr Ile Ser Arg Thr Asn Gln Leu Ala Val Gly Phe Ser 
225                 230                 235                 240


Asp Gly Tyr Leu Ala Leu Trp Asn Met Lys Ser Met Lys Arg Glu Tyr 
                245                 250                 255


Tyr Ile Gln Leu Glu Ser Gly Gln Val Pro Val Tyr Ala Val Thr Phe 
            260                 265                 270


Gln Glu Pro Glu Asn Asp Pro Arg Asn Cys Cys Tyr Leu Trp Ala Val 
        275                 280                 285


Gln Ser Thr Gln Asp Ser Glu Gly Asp Val Leu Ser Leu His Leu Leu 
    290                 295                 300


Gln Leu Ala Phe Gly Asn Arg Lys Cys Leu Ala Ser Gly Gln Ile Leu 
305                 310                 315                 320


Tyr Glu Gly Leu Glu Tyr Cys Glu Glu Arg Tyr Thr Leu Asp Leu Thr 
                325                 330                 335


Gly Gly Met Phe Pro Leu Arg Gly Gln Thr Ser Asn Thr Lys Leu Leu 
            340                 345                 350


Gly Cys Gln Ser Ile Glu Lys Phe Arg Ser His Gly Asp Arg Glu Glu 
        355                 360                 365


Gly Val Asn Glu Ala Leu Ser Pro Asp Thr Ser Val Ser Val Phe Thr 
    370                 375                 380


Trp Gln Val Asn Ile Tyr Gly Gln Gly Lys Pro Ser Val Tyr Leu Gly 
385                 390                 395                 400


Leu Phe Asp Ile Asn Arg Trp Tyr His Ala Gln Met Pro Asp Ser Leu 
                405                 410                 415


Arg Ser Gly Glu Tyr Leu His Asn Cys Ser Tyr Phe Ala Leu Trp Ser 
            420                 425                 430


Leu Glu Ser Val Val Ser Arg Thr Ser Pro His Gly Ile Leu Asp Ile 
        435                 440                 445


Leu Val His Glu Arg Ser Leu Asn Arg Gly Val Pro Pro Ser Tyr Pro 
    450                 455                 460


Pro Pro Glu Gln Phe Phe Asn Pro Ser Thr Tyr Asn Phe Asp Ala Thr 
465                 470                 475                 480


Cys Leu Leu Asn Ser Gly Val Val His Leu Thr Cys Thr Gly Phe Gln 
                485                 490                 495


Lys Glu Thr Leu Thr Phe Leu Lys Lys Ser Gly Pro Ser Leu Asn Glu 
            500                 505                 510


Leu Ile Pro Asp Gly Tyr Asn Arg Cys Leu Val Ala Gly Leu Leu Ser 
        515                 520                 525


Pro Arg Phe Val Asp Val Gln Pro Ser Ser Leu Ser Gln Glu Glu Gln 
    530                 535                 540


Leu Glu Ala Ile Leu Ser Ala Ala Ile Gln Thr Ser Ser Leu Gly Leu 
545                 550                 555                 560


Leu Thr Gly Tyr Ile Arg Arg Trp Ile Thr Glu Glu Gln Pro Asn Ser 
                565                 570                 575


Ala Thr Asn Leu Arg Phe Val Leu Glu Trp Thr Trp Asn Lys Val Val 
            580                 585                 590


Leu Thr Lys Glu Glu Phe Asp Arg Leu Cys Val Pro Leu Phe Asp Gly 
        595                 600                 605


Ser Cys His Phe Met Asp Pro Gln Thr Ile Gln Ser Ile Gln Gln Cys 
    610                 615                 620


Tyr Leu Leu Leu Ser Asn Leu Asn Ile Val Leu Ser Cys Phe Ala Ser 
625                 630                 635                 640


Glu Ala Arg Glu Ile Thr Glu Arg Gly Leu Ile Asp Leu Ser Asn Lys 
                645                 650                 655


Phe Val Val Ser His Leu Ile Cys Gln Tyr Ala Gln Val Val Leu Trp 
            660                 665                 670


Phe Ser His Ser Gly Leu Leu Pro Glu Gly Ile Asp Asp Ser Val Gln 
        675                 680                 685


Leu Ser Arg Leu Cys Tyr Asn Tyr Pro Val Ile Gln Asn Tyr Tyr Thr 
    690                 695                 700


Ser Arg Arg Gln Lys Phe Glu Arg Leu Ser Arg Gly Lys Trp Asn Pro 
705                 710                 715                 720


Asp Cys Leu Met Ile Asp Gly Leu Val Ser Gln Leu Gly Glu Arg Ile 
                725                 730                 735


Glu Lys Leu Trp Lys Arg Asp Glu Gly Gly Thr Gly Lys Tyr Pro Pro 
            740                 745                 750


Ala Ser Leu His Ala Val Leu Asp Met Tyr Leu Leu Asp Gly Val Thr 
        755                 760                 765


Glu Ala Ala Lys His Ser Ile Thr Ile Tyr Leu Leu Leu Asp Ile Met 
    770                 775                 780


Tyr Ser Phe Pro Asn Lys Thr Asp Thr Pro Ile Glu Ser Phe Pro Thr 
785                 790                 795                 800


Val Phe Ala Ile Ser Trp Gly Gln Val Lys Leu Ile Gln Gly Phe Trp 
                805                 810                 815


Leu Ile Asp His Asn Asp Tyr Glu Ser Gly Leu Asp Leu Leu Phe His 
            820                 825                 830


Pro Ala Thr Ala Lys Pro Leu Ser Trp Gln His Ser Lys Ile Ile Gln 
        835                 840                 845


Ala Phe Met Ser Gln Gly Glu His Arg Gln Ala Leu Arg Tyr Ile Gln 
    850                 855                 860


Thr Met Lys Pro Thr Val Ser Ser Gly Asn Asp Val Ile Leu His Leu 
865                 870                 875                 880


Thr Val Leu Leu Phe Asn Arg Cys Met Val Glu Ala Trp Asn Phe Leu 
                885                 890                 895


Arg Gln His Cys Asn Arg Leu Asn Ile Glu Glu Leu Leu Lys His Met 
            900                 905                 910


Tyr Glu Val Cys Gln Glu Met Gly Leu Met Glu Asp Leu Leu Lys Leu 
        915                 920                 925


Pro Phe Thr Asp Thr Glu Gln Glu Cys Leu Val Lys Phe Leu Gln Ser 
    930                 935                 940


Ser Ala Ser Val Gln Asn His Glu Phe Leu Leu Val His His Leu Gln 
945                 950                 955                 960


Arg Ala Asn Tyr Val Pro Ala Leu Lys Leu Asn Gln Thr Leu Lys Ile 
                965                 970                 975


Asn Val Met Asn Asp Arg Asp Pro Arg Leu Arg Glu Arg Ser Leu Ala 
            980                 985                 990


Arg Asn Ser Ile Leu Asp Gln Tyr Gly Lys Ile Leu Pro Arg Val His 
        995                 1000                1005


Arg Lys Leu Ala Ile Glu Arg Ala Lys Pro Tyr His Leu Ser Thr Ser 
    1010                1015                1020


Ser Val Phe Arg Leu Val Ser Arg Pro Lys Pro Leu Ser Ala Val Pro 
1025                1030                1035                1040


Lys Gln Val Val Thr Gly Thr Val Leu Thr Arg Ser Val Phe Ile Asn 
                1045                1050                1055


Asn Val Leu Ser Lys Ile Gly Glu Val Trp Ala Ser Lys Glu Pro Ile 
            1060                1065                1070


Asn Ser Thr Thr Pro Phe Asn Ser Ser Lys Ile Glu Glu Pro Ser Pro 
        1075                1080                1085


Ile Val Tyr Ser Leu Pro Ala Pro Glu Leu Pro Glu Ala Phe Phe Gly 
    1090                1095                1100


Thr Pro Ile Ser Lys Ala Ser Gln Lys Ile Ser Arg Leu Leu Asp Leu 
1105                1110                1115                1120


Val Val Gln Pro Val Pro Arg Pro Ser Gln Cys Ser Glu Phe Ile Gln 
                1125                1130                1135


Gln Ser Ser Met Lys Ser Pro Leu Tyr Leu Val Ser Arg Ser Leu Pro 
            1140                1145                1150


Ser Ser Ser Gln Leu Lys Gly Ser Pro Gln Ala Ile Ser Arg Ala Ser 
        1155                1160                1165


Glu Leu His Leu Leu Glu Thr Pro Leu Val Val Lys Lys Ala Lys Ser 
    1170                1175                1180


Leu Ala Met Ser Val Thr Thr Ser Gly Phe Ser Glu Phe Thr Pro Gln 
1185                1190                1195                1200


Ser Ile Leu Arg Ser Thr Leu Arg Ser Thr Pro Leu Ala Ser Pro Ser 
                1205                1210                1215


Pro Ser Pro Gly Arg Ser Pro Gln Arg Leu Lys Glu Thr Arg Ile Ser 
            1220                1225                1230


Phe Val Glu Glu Asp Val His Pro Lys Trp Ile Pro Gly Ala Ala Asp 
        1235                1240                1245


Asp Ser Lys Leu Glu Val Phe Thr Thr Pro Lys Lys Cys Ala Val Pro 
    1250                1255                1260


Val Glu Thr Glu Trp Leu Lys Ser Lys Asp Arg Thr Thr Ser Phe Phe 
1265                1270                1275                1280


Leu Asn Ser Pro Glu Lys Glu His Gln Glu Met Asp Glu Gly Ser Gln 
                1285                1290                1295


Ser Leu Glu Lys Leu Asp Val Ser Lys Gly Asn Ser Ser Val Ser Ile 
            1300                1305                1310


Thr Ser Asp Glu Thr Thr Leu Glu Tyr Gln Asp Ala Pro Ser Pro Glu 
        1315                1320                1325


Asp Leu Glu Glu Thr Val Phe Thr Ala Ser Lys Pro Lys Ser Ser Ser 
    1330                1335                1340


Thr Ala Leu Thr Thr Asn Val Thr Glu Gln Thr Glu Lys Asp Gly Asp 
1345                1350                1355                1360


Lys Asp Val Phe Ala Ser Glu Val Thr Pro Ser Asp Leu Gln Lys Gln 
                1365                1370                1375


Met Gly Asn Leu Glu Asp Ala Glu Thr Lys Asp Leu Leu Val Ala Ala 
            1380                1385                1390


Glu Ala Phe Ser Glu Leu Asn His Leu Ser Pro Val Gln Gly Thr Glu 
        1395                1400                1405


Ala Ser Leu Cys Ala Pro Ser Val Tyr Glu Gly Lys Ile Phe Thr Gln 
    1410                1415                1420


Lys Ser Lys Val Pro Val Leu Asp Glu Gly Leu Thr Ser Val Glu Thr 
1425                1430                1435                1440


Tyr Thr Pro Ala Ile Arg Ala Asn Asp Asn Lys Ser Met Ala Asp Val 
                1445                1450                1455


Leu Gly Asp Gly Gly Asn Ser Ser Leu Thr Ile Ser Glu Gly Pro Ile 
            1460                1465                1470


Val Ser Glu Arg Arg Leu Asn Gln Glu Val Ala Leu Asn Leu Lys Glu 
        1475                1480                1485


Asp His Glu Val Glu Val Gly Val Leu Lys Glu Ser Val Asp Leu Pro 
    1490                1495                1500


Glu Glu Lys Leu Pro Ile Ser Asp Ser Pro Pro Asp Thr Gln Glu Ile 
1505                1510                1515                1520


His Val Ile Glu Gln Glu Lys Leu Glu Ala Gln Asp Ser Gly Glu Glu 
                1525                1530                1535


Ala Arg Asn Leu Ser Phe Asn Glu Leu Tyr Pro Ser Gly Thr Leu Lys 
            1540                1545                1550


Leu Gln Tyr Asn Phe Asp Thr Ile Asp Gln Gln Phe Cys Asp Leu Ala 
        1555                1560                1565


Asp Asn Lys Asp Thr Ala Glu Cys Asp Ile Ala Glu Val Asp Gly Glu 
    1570                1575                1580


Leu Phe Val Ala Gln Ser Asn Phe Thr Leu Ile Leu Glu Gly Glu Glu 
1585                1590                1595                1600


Gly Glu Val Glu Pro Gly Asp Phe Ala Ser Ser Asp Val Leu Pro Lys 
                1605                1610                1615


Ala Ala Asn Thr Ala Thr Glu Glu Lys Leu Val Cys Ser Gly Glu Asn 
            1620                1625                1630


Asp Asn His Gly Gln Ile Ala Asn Leu Pro Ser Ala Val Thr Ser Asp 
        1635                1640                1645


Gln Lys Ser Gln Lys Val Asp Thr Leu Pro Tyr Val Pro Glu Pro Ile 
    1650                1655                1660


Lys Val Ala Ile Ala Glu Asn Leu Leu Asp Val Ile Lys Asp Thr Arg 
1665                1670                1675                1680


Ser Lys Glu Ile Thr Ser Asp Thr Met Glu Gln Ser Ile His Glu Thr 
                1685                1690                1695


Ile Pro Leu Val Ser Gln Asn Ile Met Cys Pro Thr Lys Leu Val Lys 
            1700                1705                1710


Ser Ala Phe Lys Thr Ala Gln Glu Thr Ser Thr Met Thr Met Asn Val 
        1715                1720                1725


Ser Gln Val Asp Asp Val Val Ser Ser Lys Thr Arg Thr Arg Gly Gln 
    1730                1735                1740


Arg Ile Gln Asn Val Asn Val Lys Ser Ala Gln Gln Glu Ala Ser Ala 
1745                1750                1755                1760


Asp Val Ala Thr Pro Lys Met Pro Gly Gln Ser Val Arg Lys Lys Thr 
                1765                1770                1775


Arg Lys Ala Lys Glu Ile Ser Glu Ala Ser Glu Asn Ile Tyr Ser Asp 
            1780                1785                1790


Val Arg Gly Leu Ser Gln Asn Gln Gln Ile Pro Gln Asn Ser Val Thr 
        1795                1800                1805


Pro Arg Arg Gly Arg Arg Lys Lys Glu Val Asn Gln Asp Ile Leu Glu 
    1810                1815                1820


Asn Thr Ser Ser Val Glu Gln Glu Leu Gln Ile Thr Thr Gly Arg Glu 
1825                1830                1835                1840


Ser Lys Arg Leu Lys Ser Ser Gln Leu Leu Glu Pro Ala Val Glu Glu 
                1845                1850                1855


Thr Thr Lys Lys Glu Val Lys Val Ser Ser Val Thr Lys Arg Thr Pro 
            1860                1865                1870


Arg Arg Ile Lys Arg Ser Val Glu Asn Gln Glu Ser Val Glu Ile Ile 
        1875                1880                1885


Asn Asp Leu Lys Val Ser Thr Val Thr Ser Pro Ser Arg Met Ile Arg 
    1890                1895                1900


Lys Leu Arg Ser Thr Asn Leu Asp Ala Ser Glu Asn Thr Gly Asn Lys 
1905                1910                1915                1920


Gln Asp Asp Lys Ser Ser Asp Lys Gln Leu Arg Ile Lys His Val Arg 
                1925                1930                1935


Arg Val Arg Gly Arg Glu Val Ser Pro Ser Asp Val Arg Glu Asp Ser 
            1940                1945                1950


Asn Leu Glu Ser Ser Gln Leu Thr Val Gln Ala Glu Phe Asp Met Ser 
        1955                1960                1965


Ala Ile Pro Arg Lys Arg Gly Arg Pro Arg Lys Ile Asn Pro Ser Glu 
    1970                1975                1980


Asp Val Gly Ser Lys Ala Val Lys Glu Glu Arg Ser Pro Lys Lys Lys 
1985                1990                1995                2000


Glu Ala Pro Ser Ile Arg Arg Arg Ser Thr Arg Asn Thr Pro Ala Lys 
                2005                2010                2015


Ser Glu Asn Val Asp Val Gly Lys Pro Ala Leu Gly Lys Ser Ile Leu 
            2020                2025                2030


Val Pro Asn Glu Glu Leu Ser Met Val Met Ser Ser Lys Lys Lys Leu 
        2035                2040                2045


Thr Lys Lys Thr Glu Ser Gln Ser Gln Lys Arg Ser Leu His Ser Val 
    2050                2055                2060


Ser Glu Glu Arg Thr Asp Glu Met Thr His Lys Glu Thr Asn Glu Gln 
2065                2070                2075                2080


Glu Glu Arg Leu Leu Ala Thr Ala Ser Phe Thr Lys Ser Ser Arg Ser 
                2085                2090                2095


Ser Arg Thr Arg Ser Ser Lys Ala Ile Leu Leu Pro Asp Leu Ser Glu 
            2100                2105                2110


Pro Asn Asn Glu Pro Leu Phe Ser Pro Ala Ser Glu Val Pro Arg Lys 
        2115                2120                2125


Ala Lys Ala Lys Lys Ile Glu Val Pro Ala Gln Leu Lys Glu Leu Val 
    2130                2135                2140


Ser Asp Leu Ser Ser Gln Phe Val Ile Ser Pro Pro Ala Leu Arg Ser 
2145                2150                2155                2160


Arg Gln Lys Asn Thr Ser Asn Lys Asn Lys Leu Glu Asp Glu Leu Lys 
                2165                2170                2175


Asp Asp Ala Gln Ser Val Glu Thr Leu Gly Lys Pro Lys Ala Lys Arg 
            2180                2185                2190


Ile Arg Thr Ser Lys Thr Lys Gln Ala Ser Lys Asn Thr Glu Lys Glu 
        2195                2200                2205


Ser Ala Trp Ser Pro Pro Pro Ile Glu Ile Arg Leu Ile Ser Pro Leu 
    2210                2215                2220


Ala Ser Pro Ala Asp Gly Val Lys Ser Lys Pro Arg Lys Thr Thr Glu 
2225                2230                2235                2240


Val Thr Gly Thr Gly Leu Gly Arg Asn Arg Lys Lys Leu Ser Ser Tyr 
                2245                2250                2255


Pro Lys Gln Ile Leu Arg Arg Lys Met Leu 
            2260                2265


<210>  2162
<211>  2736
<212>  DNA
<213>  Homo sapiens

<400>  2162
tacgcctagg agaggaagga gaaagaaaga agttaatcag gacatactag aaaacaccag     60

ttctgtggaa caagaattac agatcactac aggtagggaa tcaaaaagat taaaatcatc    120

tcagctgttg gaaccagcag ttgaagaaac tactaaaaaa gaagttaagg tttcatctgt    180

tacaaaaagg actcctagaa gaattaaaag atctgtagaa aatcaggaaa gtgttgaaat    240

tataaatgat ctaaaagtta gtacggtaac aagtcctagc agaatgatca gaaaattgag    300

aagtactaat ttagatgctt ctgaaaatac aggaaataag caagatgata aatccagtga    360

caagcagctg cgtattaaac atgttagaag ggtcagaggg agagaagtta gtccatcaga    420

tgtgagagaa gactccaacc ttgagtcatc tcagttgact gttcaagcag aatttgatat    480

gtctgccata cctagaaaac gtggtagacc aagaaaaatc aatccatctg aagatgtagg    540

atctaaggct gttaaggaag agagaagccc caagaagaaa gaagctccca gcattagaag    600

gagatctaca agaaataccc cagctaaaag tgaaaatgtt gatgttggaa aaccagcttt    660

aggaaaatcc attttagtgc caaacgagga actttcgatg gtgatgagct ctaagaaaaa    720

acttacaaaa aagactgaaa gtcaaagcca aaaacgttca ttgcactcag tatcagaaga    780

acgcacagat gaaatgacac ataaagaaac aaatgagcag gaagaaagat tgctcgccac    840

agcttccttc actaaatcat cccgcagcag caggactcgg tctagcaagg ccatcttgtt    900

gccggacctt tctgaaccaa acaatgagcc tttattttct ccagcgtcag aagttccaag    960

gaaagcaaaa gaaagatgat gcacaatcag tagaaactct gggaaagcca aaagcgaaac   1020

gaatcaggac gtcaaaaaca aaacaagcaa gcaaaaacac agaaaaagaa agtgcttggt   1080

cacctcctcc catagaaatt cggctgattt cccccttggc tagcccagct gacggagtca   1140

agagcaaacc aagaaaaact acagaagtga caggaacagg tcttggaagg aacagaaaga   1200

aactgtcttc ctatccaaag caaattttac gcagaaaaat gctgtaattt cttgggaaga   1260

ttttaatgta cacctatttg taaagtcatc agaatagtgt ggattattaa atatctagtt   1320

tggaagaaaa taatttatat aaattattgt aaatttttat gtaaacagaa ggtcttcaat   1380

aagtaaagta actccatatg gagtgattgt ttcagtccag gcaatttttc tattttatat   1440

taagacttca tacatttata tatgtaaata tggcttatta atggaatgtt aaataaaatg   1500

tatacttcac agtcgtttgt gtcttggatt tttgaaaggg aggggatatc tgtttaaata   1560

gttttatatg ctcattggtc tcattttctc tataattaaa atactagacc agtcttaaaa   1620

tggggatgat tgaagtattg atatttcttt ttacagttac tattttataa tttatgcact   1680

ttgattctgt gattcagatt tctaatcaga aaatgtattt ttttgttttt ggctgttact   1740

atgttaaaat tgaattatgg gcatgtcatt ttgccatctt tgtagtttca caaattttgt   1800

gtaatctacc tcaaatgaat aatccaagta ttggttaact ataatgttgg catctcttat   1860

tcggcaagct taaaggctct ttaaagtctt aattagtcaa agactaatcc aggttagatt   1920

gaccggttca ctgctcactt gcaaccttat caaagggttt gacaaaggga aatgtaaaat   1980

aaatctgttt atggatattg agtgcatctt gtatgtgcct aatattgata ggatgagatg   2040

tctgaacaaa tttttataat attgctgtga aggagcttgc tattgaacca cagaaatccc   2100

ttaatattca ggttttaaaa ctggcaaatt ctcacaggac ctcaggcaca gattattgag   2160

gttgggagag agtgagtaga tgtagaaaag gagaaaaaca acacacgccc tgttctctac   2220

agtacaactg tgtgcaatta agcaatggta cttgatgtag gctctaacac tcatcaataa   2280

ataagtgttg taaaataatt tataacaggt aatcgatagt gtgtaatgaa tggactatta   2340

ataattgatt atctagaaac gaactgcttt cgtgggcttt taatatttta atgtgaagca   2400

tatgcagtgt gctttctgca tttatttttc taccaaataa tacagataat gagaaattgg   2460

tgaaaatgcc tacgcaaagt gttgacagtg tgaaagcagt gcgagtgcgg ccttttagtc   2520

aggttagtga tggatgttac gctgccttgt tgaaaatttc actgactttg attttattac   2580

ttttttaatg atagttatca aacttgtatt taagctgctt gtcatttatg gaatattgaa   2640

cttatttaaa tgaacttgtt aaatgaataa agagctaaac ataattcagt aaacaattcc   2700

tttgcgcaag tagcacaata aacatggatg caacgt                             2736


<210>  2163
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  2163

Met Ile Arg Lys Leu Arg Ser Thr Asn Leu Asp Ala Ser Glu Asn Thr 
1               5                   10                  15


Gly Asn Lys Gln Asp Asp Lys Ser Ser Asp Lys Gln Leu Arg Ile Lys 
            20                  25                  30


His Val Arg Arg Val Arg Gly Arg Glu Val Ser Pro Ser Asp Val Arg 
        35                  40                  45


Glu Asp Ser Asn Leu Glu Ser Ser Gln Leu Thr Val Gln Ala Glu Phe 
    50                  55                  60


Asp Met Ser Ala Ile Pro Arg Lys Arg Gly Arg Pro Arg Lys Ile Asn 
65                  70                  75                  80


Pro Ser Glu Asp Val Gly Ser Lys Ala Val Lys Glu Glu Arg Ser Pro 
                85                  90                  95


Lys Lys Lys Glu Ala Pro Ser Ile Arg Arg Arg Ser Thr Arg Asn Thr 
            100                 105                 110


Pro Ala Lys Ser Glu Asn Val Asp Val Gly Lys Pro Ala Leu Gly Lys 
        115                 120                 125


Ser Ile Leu Val Pro Asn Glu Glu Leu Ser Met Val Met Ser Ser Lys 
    130                 135                 140


Lys Lys Leu Thr Lys Lys Thr Glu Ser Gln Ser Gln Lys Arg Ser Leu 
145                 150                 155                 160


His Ser Val Ser Glu Glu Arg Thr Asp Glu Met Thr His Lys Glu Thr 
                165                 170                 175


Asn Glu Gln Glu Glu Arg Leu Leu Ala Thr Ala Ser Phe Thr Lys Ser 
            180                 185                 190


Ser Arg Ser Ser Arg Thr Arg Ser Ser Lys Ala Ile Leu Leu Pro Asp 
        195                 200                 205


Leu Ser Glu Pro Asn Asn Glu Pro Leu Phe Ser Pro Ala Ser Glu Val 
    210                 215                 220


Pro Arg Lys Ala Lys Glu Arg 
225                 230


<210>  2164
<211>  6794
<212>  DNA
<213>  Homo sapiens

<400>  2164
agactttgac ttttttaaag aaatcaggtc catcactcaa tgaactcatt cctgatggtt     60

ataatcgatg tcttgtagct ggccttcttt ccccaagatt tgttgatgtt cagccttcca    120

gtttaagcca agaagaacag ttagaagcta tattgtcagc agcaattcag actagttccc    180

tgggactttt gactggttat atccgaagat ggataacaga agaacaacca aattctgcca    240

ctaatttgcg ctttgttctt gaatggacgt ggaataaagt ggttctcaca aaagaggaat    300

ttgacagact atgtgtgcca ttatttgatg gttcgtgtca tttcatggat ccacaaacta    360

tacagtctat ccagcaatgc tatttgcttc ttagcaatct taatatagtc ttgagctgtt    420

ttgcatcaga agcccgagag atcactgaga gaggactgat agacttaagc aataagtttg    480

tggtttccca cctcatctgt cagtatgcac aagtggttct ttggttctct cattctgggc    540

ttttaccaga aggcatagat gattctgtgc agttgtcaag gttatgctac aactaccctg    600

taattcagaa ctactacacc agtcgtcgac agaagtttga gcgtttatca agagggaagt    660

ggaatcccga ttgcttgatg attgatggac tggtttctca gttaggagag cgaattgaga    720

agttgtggaa acgagatgaa ggaggcacag gaaaatatcc tcctgctagt ctgcatgcag    780

tacttgatat gtacctatta gacggcgtta ctgaagcagc caaacactct attaccattt    840

atttgctact tgatattatg tattcctttc ccaacaaaac agacactccc attgaatctt    900

tcccaactgt atttgccatt tcttggggcc aagttaaact tattcagggg ttttggttga    960

tagatcataa tgactatgag agtggtttgg atcttttgtt tcatccagct actgcaaaac   1020

ctttgtcatg gcaacattca aagattattc aggcattcat gagtcagggc gagcacagac   1080

aagccctcag atatattcag acaatgaagc caacagtgtc cagtggtaac gatgttatcc   1140

ttcacctcac tgttttgctt tttaataggt gtatggttga agcctggaat tttttgcggc   1200

aacattgcaa taggttgaat atagaggagt tactgaagca catgtatgaa gtctgtcagg   1260

aaatgggctt gatggaagat ttactgaagt taccatttac agacactgag caggaatgtt   1320

tagtgaaatt tttgcagtcc agtgccagcg ttcagaatca tgaattcctt ttagtgcacc   1380

atttgcagcg tgccaattat gtgcctgcct tgaagctgaa ccaaactctg aagattaatg   1440

ttatgaatga tcgtgatcct cgtttgcggg agagatcact ggctcgaaat tctatattag   1500

accagtatgg aaaaatcctt cctagagtcc atcgaaaatt agccattgaa cgagctaagc   1560

cttatcatct gtcaacatca tcagtttttc gattagtttc tagacccaaa ccattatcag   1620

cagttccaaa gcaagttgta acaggaactg tgttgacaag atctgttttc atcaacaatg   1680

tgttatctaa aattggagaa gtttgggcaa gcaaagaacc tataaatagc accacacctt   1740

tcaatagttc taaaatagaa gaaccatctc ctatagtgta ttcgctccca gctccagagc   1800

tgcctgaggc attttttgga acaccaattt caaaagcatc acaaaaaatt tctagaatga   1860

caaggaaggt actgcaacta caagttttta tttctgggct ccaaagcata ctctcctttt   1920

ctggttattc tcagactgct agatttggtt gttcagcctg tcccccggcc ttctcagtgt   1980

tcggagttta ttcagcaaag ctccatgaaa tctcctttgt acctagtatc ccgttcactg   2040

ccctcaagtt cgcaattaaa aggatcgcct caggccatct ccagggcttc agaattacat   2100

ttgcttgaaa ctcctcttgt agttaagaaa gctaaaagtt tggccatgtc agttactact   2160

tctggatttt ctgagttcac tcctcagtcc atcctgaggt ctactcttcg atcaacacct   2220

ttagcatctc cctctccatc acctggaagg tctcctcaac gacttaaaga aactagaatt   2280

tcatttgtgg aagaagatgt ccacccaaaa tggattcctg gggctgcaga tgatagcaaa   2340

ttagaagtat ttactacacc taaaaaatgt gcagttccag tggaaactga atggctgaag   2400

agcaaagata ggaccacatc ttttttcctg aacagccctg aaaaggagca tcaagaaatg   2460

gatgaggggt cacaaagttt agagaaactg gatgtgagca aaggaaacag cagtgtttca   2520

atcacatccg atgagactac cttagagtat caggatgcac cgtcaccgga agaccttgaa   2580

gagactgttt tcacggcctc taagcccaaa agctcttcca ctgcactaac tactaatgta   2640

actgaacaaa ctgaaaagga tggagataaa gatgtatttg catcagaagt aactccttca   2700

gacctacaga aacaaatggg caatttagaa gatgcagaaa caaaggatct cttagttgca   2760

gcagaggcat tttcagaatt gaatcactta agcccggttc aaggaactga agcttctctt   2820

tgtgcaccat cagtctatga agggaaaatc ttcacccaga agtccaaggt accagtgttg   2880

gacgaaggat taacatctgt tgaaacctac acccctgcaa ttagagcaaa tgacaataaa   2940

tctatggctg atgtccttgg tgatggtgga aactcctcgc tcactatctc tgaaggtcct   3000

attgtctctg agcgcaggct taaccaggaa gtagcgctga acttaaaaga agatcatgaa   3060

gtagaagttg gtgtactaaa agaaagtgtt gacttaccag aagaaaagct tccaatttct   3120

gacagccctc ctgatactca agaaattcat gtgattgaac aagaaaagct tgaagctcaa   3180

gattcaggag aagaggctag gaatctttca tttaatgagt tatatccctc tggaacactt   3240

aagcttcagt acaattttga tactattgac caacagtttt gtgacttagc tgataacaaa   3300

gacactgctg aatgtgacat tgctgaagta gatggggaac tttttgtggc tcaaagcaac   3360

tttaccttga tattggaagg tgaagaagga gaagttgagc caggtgattt tgcatcatct   3420

gatgtgttac ctaaagcagc taacacagca actgaagaaa aacttgtatg cagtggggaa   3480

aatgataatc atggacaaat tgcaaatttg ccatctgccg taactagtga ccaaaagtcc   3540

caaaaagtag acactttacc atatgtgcct gaacctatta aagtagcaat tgcagaaaat   3600

ttactagatg taattaaaga cacaagaagt aaagaaatta cttcagatac aatggaacag   3660

tccattcatg aaacaatacc tttagtgagc caaaacataa tgtgtcccac taaattggtc   3720

aaatctgcat ttaagactgc tcaggaaaca agcacaatga ctatgaatgt cagccaggtt   3780

gatgacgtgg tttcctccaa aactcgtacg agaggtcaac gtatccaaaa cgtgaatgtc   3840

aaatcagcac aacaggaagc atcagcagat gttgctactc ctaagatgcc agggcagtca   3900

gtcaggaaga aaactaggaa ggcaaaagaa atttctgaag cttctgaaaa catctattct   3960

gatgtcagag gactatctca gaaccagcaa atacctcaaa attctgttac gcctaggaga   4020

ggaaggagaa agaaagaagt taatcaggac atactagaaa acaccagttc tgtggaacaa   4080

gaattacaga tcactacagg tagggaatca aaaagattaa aatcatctca gctgttggaa   4140

ccagcagttg aagaaactac taaaaaagaa gttaaggttt catctgttac aaaaaggact   4200

cctagaagaa ttaaaagatc tgtagaaaat caggaaagtg ttgaaattat aaatgatcta   4260

aaagttagta cggtaacaag tcctagcaga atgatcagaa aattgagaag tactaattta   4320

gatgcttctg aaaatacagg aaataagcaa gatgataaat ccagtgacaa gcagctgcgt   4380

attaaacatg ttagaagggt cagagggaga gaagttagtc catcagatgt gagagaagac   4440

tccaaccttg agtcatctca gttgactgtt caagcagaat ttgatatgtc tgccatacct   4500

agaaaacgtg gtagaccaag aaaaatcaat ccatctgaag atgtaggatc taaggctgtt   4560

aaggaagaga gaagccccaa gaagaaagaa gctcccagca ttagaaggag atctacaaga   4620

aataccccag ctaaaagtga aaatgttgat gttggaaaac cagctttagg aaaatccatt   4680

ttagtgccaa acgaggaact ttcgatggtg atgagctcta agaaaaaact tacaaaaaag   4740

actgaaagtc aaagccaaaa acgttcattg cactcagtat cagaagaacg cacagatgaa   4800

atgacacata aagaaacaaa tgagcaggaa gaaagattgc tcgccacagc ttccttcact   4860

aaatcatccc gcagcagcag gactcggtct agcaaggcca tcttgttgcc ggacctttct   4920

gaaccaaaca atgagccttt attttctcca gcgtcagaag ttccaaggaa agcaaaagct   4980

aaaaaaatag aggttcctgc acagctgaaa gaattagttt cggatttatc ttctcagttt   5040

gtcatctcac ctcctgcttt aaggagcaga caaaaaaaca catccaataa gaacaagctt   5100

gaagatgaac tgaaacacag aaaaagaaag tgcttggtca cctcctccca tagaaattcg   5160

gctgatttcc cccttggcta gcccagctga cggagtcaag agcaaaccaa gaaaaactac   5220

agaagtgaca ggaacaggtc ttggaaggaa cagaaagaaa ctgtcttcct atccaaagca   5280

aattttacgc agaaaaatgc tgtaatttct tgggaagatt ttaatgtaca cctatttgta   5340

aagtcatcag aatagtgtgg attattaaat atctagtttg gaagaaaata atttatataa   5400

attattgtaa atttttatgt aaacagaagg tcttcaataa gtaaagtaac tccatatgga   5460

gtgattgttt cagtccaggc aatttttcta ttttatatta agacttcata catttatata   5520

tgtaaatatg gcttattaat ggaatgttaa ataaaatgta tacttcacag tcgtttgtgt   5580

cttggatttt tgaaagggag gggatatctg tttaaatagt tttatatgct cattggtctc   5640

attttctcta taattaaaat actagaccag tcttaaaatg gggatgattg aagtattgat   5700

atttcttttt acagttacta ttttataatt tatgcacttt gattctgtga ttcagatttc   5760

taatcagaaa atgtattttt ttgtttttgg ctgttactat gttaaaattg aattatgggc   5820

atgtcatttt gccatctttg tagtttcaca aattttgtgt aatctacctc aaatgaataa   5880

tccaagtatt ggttaactat aatgttggca tctcttattc ggcaagctta aaggctcttt   5940

aaagtcttaa ttagtcaaag actaatccag gttagattga ccggttcact gctcacttgc   6000

aaccttatca aagggtttga caaagggaaa tgtaaaataa atctgtttat ggatattgag   6060

tgcatcttgt atgtgcctaa tattgatagg atgagatgtc tgaacaaatt tttataatat   6120

tgctgtgaag gagcttgcta ttgaaccaca gaaatccctt aatattcagg ttttaaaact   6180

ggcaaattct cacaggacct caggcacaga ttattgaggt tgggagagag tgagtagatg   6240

tagaaaagga gaaaaacaac acacgccctg ttctctacag tacaactgtg tgcaattaag   6300

caatggtact tgatgtaggc tctaacactc atcaataaat aagtgttgta aaataattta   6360

taacaggtaa tcgatagtgt gtaatgaatg gactattaat aattgattat ctagaaacga   6420

actgctttcg tgggctttta atattttaat gtgaagcata tgcagtgtgc tttctgcatt   6480

tatttttcta ccaaataata cagataatga gaaattggtg aaaatgccta cgcaaagtgt   6540

tgacagtgtg aaagcagtgc gagtgcggcc ttttagtcag gttagtgatg gatgttacgc   6600

tgccttgttg aaaatttcac tgactttgat tttattactt ttttaatgat agttatcaaa   6660

cttgtattta agctgcttgt catttatgga atattgaact tatttaaatg aacttgttaa   6720

atgaataaag agctaaacat aattcagtaa acaattcctt tgcgcaagta gcacaataaa   6780

catggatgca acgt                                                     6794


<210>  2165
<211>  1058
<212>  PRT
<213>  Homo sapiens

<400>  2165

Met Lys Ser Pro Leu Tyr Leu Val Ser Arg Ser Leu Pro Ser Ser Ser 
1               5                   10                  15


Gln Leu Lys Gly Ser Pro Gln Ala Ile Ser Arg Ala Ser Glu Leu His 
            20                  25                  30


Leu Leu Glu Thr Pro Leu Val Val Lys Lys Ala Lys Ser Leu Ala Met 
        35                  40                  45


Ser Val Thr Thr Ser Gly Phe Ser Glu Phe Thr Pro Gln Ser Ile Leu 
    50                  55                  60


Arg Ser Thr Leu Arg Ser Thr Pro Leu Ala Ser Pro Ser Pro Ser Pro 
65                  70                  75                  80


Gly Arg Ser Pro Gln Arg Leu Lys Glu Thr Arg Ile Ser Phe Val Glu 
                85                  90                  95


Glu Asp Val His Pro Lys Trp Ile Pro Gly Ala Ala Asp Asp Ser Lys 
            100                 105                 110


Leu Glu Val Phe Thr Thr Pro Lys Lys Cys Ala Val Pro Val Glu Thr 
        115                 120                 125


Glu Trp Leu Lys Ser Lys Asp Arg Thr Thr Ser Phe Phe Leu Asn Ser 
    130                 135                 140


Pro Glu Lys Glu His Gln Glu Met Asp Glu Gly Ser Gln Ser Leu Glu 
145                 150                 155                 160


Lys Leu Asp Val Ser Lys Gly Asn Ser Ser Val Ser Ile Thr Ser Asp 
                165                 170                 175


Glu Thr Thr Leu Glu Tyr Gln Asp Ala Pro Ser Pro Glu Asp Leu Glu 
            180                 185                 190


Glu Thr Val Phe Thr Ala Ser Lys Pro Lys Ser Ser Ser Thr Ala Leu 
        195                 200                 205


Thr Thr Asn Val Thr Glu Gln Thr Glu Lys Asp Gly Asp Lys Asp Val 
    210                 215                 220


Phe Ala Ser Glu Val Thr Pro Ser Asp Leu Gln Lys Gln Met Gly Asn 
225                 230                 235                 240


Leu Glu Asp Ala Glu Thr Lys Asp Leu Leu Val Ala Ala Glu Ala Phe 
                245                 250                 255


Ser Glu Leu Asn His Leu Ser Pro Val Gln Gly Thr Glu Ala Ser Leu 
            260                 265                 270


Cys Ala Pro Ser Val Tyr Glu Gly Lys Ile Phe Thr Gln Lys Ser Lys 
        275                 280                 285


Val Pro Val Leu Asp Glu Gly Leu Thr Ser Val Glu Thr Tyr Thr Pro 
    290                 295                 300


Ala Ile Arg Ala Asn Asp Asn Lys Ser Met Ala Asp Val Leu Gly Asp 
305                 310                 315                 320


Gly Gly Asn Ser Ser Leu Thr Ile Ser Glu Gly Pro Ile Val Ser Glu 
                325                 330                 335


Arg Arg Leu Asn Gln Glu Val Ala Leu Asn Leu Lys Glu Asp His Glu 
            340                 345                 350


Val Glu Val Gly Val Leu Lys Glu Ser Val Asp Leu Pro Glu Glu Lys 
        355                 360                 365


Leu Pro Ile Ser Asp Ser Pro Pro Asp Thr Gln Glu Ile His Val Ile 
    370                 375                 380


Glu Gln Glu Lys Leu Glu Ala Gln Asp Ser Gly Glu Glu Ala Arg Asn 
385                 390                 395                 400


Leu Ser Phe Asn Glu Leu Tyr Pro Ser Gly Thr Leu Lys Leu Gln Tyr 
                405                 410                 415


Asn Phe Asp Thr Ile Asp Gln Gln Phe Cys Asp Leu Ala Asp Asn Lys 
            420                 425                 430


Asp Thr Ala Glu Cys Asp Ile Ala Glu Val Asp Gly Glu Leu Phe Val 
        435                 440                 445


Ala Gln Ser Asn Phe Thr Leu Ile Leu Glu Gly Glu Glu Gly Glu Val 
    450                 455                 460


Glu Pro Gly Asp Phe Ala Ser Ser Asp Val Leu Pro Lys Ala Ala Asn 
465                 470                 475                 480


Thr Ala Thr Glu Glu Lys Leu Val Cys Ser Gly Glu Asn Asp Asn His 
                485                 490                 495


Gly Gln Ile Ala Asn Leu Pro Ser Ala Val Thr Ser Asp Gln Lys Ser 
            500                 505                 510


Gln Lys Val Asp Thr Leu Pro Tyr Val Pro Glu Pro Ile Lys Val Ala 
        515                 520                 525


Ile Ala Glu Asn Leu Leu Asp Val Ile Lys Asp Thr Arg Ser Lys Glu 
    530                 535                 540


Ile Thr Ser Asp Thr Met Glu Gln Ser Ile His Glu Thr Ile Pro Leu 
545                 550                 555                 560


Val Ser Gln Asn Ile Met Cys Pro Thr Lys Leu Val Lys Ser Ala Phe 
                565                 570                 575


Lys Thr Ala Gln Glu Thr Ser Thr Met Thr Met Asn Val Ser Gln Val 
            580                 585                 590


Asp Asp Val Val Ser Ser Lys Thr Arg Thr Arg Gly Gln Arg Ile Gln 
        595                 600                 605


Asn Val Asn Val Lys Ser Ala Gln Gln Glu Ala Ser Ala Asp Val Ala 
    610                 615                 620


Thr Pro Lys Met Pro Gly Gln Ser Val Arg Lys Lys Thr Arg Lys Ala 
625                 630                 635                 640


Lys Glu Ile Ser Glu Ala Ser Glu Asn Ile Tyr Ser Asp Val Arg Gly 
                645                 650                 655


Leu Ser Gln Asn Gln Gln Ile Pro Gln Asn Ser Val Thr Pro Arg Arg 
            660                 665                 670


Gly Arg Arg Lys Lys Glu Val Asn Gln Asp Ile Leu Glu Asn Thr Ser 
        675                 680                 685


Ser Val Glu Gln Glu Leu Gln Ile Thr Thr Gly Arg Glu Ser Lys Arg 
    690                 695                 700


Leu Lys Ser Ser Gln Leu Leu Glu Pro Ala Val Glu Glu Thr Thr Lys 
705                 710                 715                 720


Lys Glu Val Lys Val Ser Ser Val Thr Lys Arg Thr Pro Arg Arg Ile 
                725                 730                 735


Lys Arg Ser Val Glu Asn Gln Glu Ser Val Glu Ile Ile Asn Asp Leu 
            740                 745                 750


Lys Val Ser Thr Val Thr Ser Pro Ser Arg Met Ile Arg Lys Leu Arg 
        755                 760                 765


Ser Thr Asn Leu Asp Ala Ser Glu Asn Thr Gly Asn Lys Gln Asp Asp 
    770                 775                 780


Lys Ser Ser Asp Lys Gln Leu Arg Ile Lys His Val Arg Arg Val Arg 
785                 790                 795                 800


Gly Arg Glu Val Ser Pro Ser Asp Val Arg Glu Asp Ser Asn Leu Glu 
                805                 810                 815


Ser Ser Gln Leu Thr Val Gln Ala Glu Phe Asp Met Ser Ala Ile Pro 
            820                 825                 830


Arg Lys Arg Gly Arg Pro Arg Lys Ile Asn Pro Ser Glu Asp Val Gly 
        835                 840                 845


Ser Lys Ala Val Lys Glu Glu Arg Ser Pro Lys Lys Lys Glu Ala Pro 
    850                 855                 860


Ser Ile Arg Arg Arg Ser Thr Arg Asn Thr Pro Ala Lys Ser Glu Asn 
865                 870                 875                 880


Val Asp Val Gly Lys Pro Ala Leu Gly Lys Ser Ile Leu Val Pro Asn 
                885                 890                 895


Glu Glu Leu Ser Met Val Met Ser Ser Lys Lys Lys Leu Thr Lys Lys 
            900                 905                 910


Thr Glu Ser Gln Ser Gln Lys Arg Ser Leu His Ser Val Ser Glu Glu 
        915                 920                 925


Arg Thr Asp Glu Met Thr His Lys Glu Thr Asn Glu Gln Glu Glu Arg 
    930                 935                 940


Leu Leu Ala Thr Ala Ser Phe Thr Lys Ser Ser Arg Ser Ser Arg Thr 
945                 950                 955                 960


Arg Ser Ser Lys Ala Ile Leu Leu Pro Asp Leu Ser Glu Pro Asn Asn 
                965                 970                 975


Glu Pro Leu Phe Ser Pro Ala Ser Glu Val Pro Arg Lys Ala Lys Ala 
            980                 985                 990


Lys Lys Ile Glu Val Pro Ala Gln Leu Lys Glu Leu Val Ser Asp Leu 
        995                 1000                1005


Ser Ser Gln Phe Val Ile Ser Pro Pro Ala Leu Arg Ser Arg Gln Lys 
    1010                1015                1020


Asn Thr Ser Asn Lys Asn Lys Leu Glu Asp Glu Leu Lys His Arg Lys 
1025                1030                1035                1040


Arg Lys Cys Leu Val Thr Ser Ser His Arg Asn Ser Ala Asp Phe Pro 
                1045                1050                1055


Leu Gly 



<210>  2166
<211>  2682
<212>  DNA
<213>  Homo sapiens

<400>  2166
tacgcctagg agaggaagga gaaagaaaga agttaatcag gacatactag aaaacaccag     60

ttctgtggaa caagaattac agatcactac aggtagggaa tcaaaaagat taaaatcatc    120

tcagctgttg gaaccagcag ttgaagaaac tactaaaaaa gaagttaagg tttcatctgt    180

tacaaaaagg actcctagaa gaattaaaag atctgtagaa aatcaggaaa gtgttgaaat    240

tataaatgat ctaaaagtta gtacggtaac aagtcctagc agaatgatca gaaaattgag    300

aagtactaat ttagatgctt ctgaaaatac aggaaataag caagatgata aatccagtga    360

caagcagctg cgtattaaac atgttagaag ggtcagaggg agagaagtta gtccatcaga    420

tgtgagagaa gactccaacc ttgagtcatc tcagttgact gttcaagcag aatttgatat    480

gtctgccata cctagaaaac gtggtagacc aagaaaaatc aatccatctg aagatgtagg    540

atctaaggct gttaaggaag agagaagccc caagaagaaa gaagctccca gcattagaag    600

gagatctaca agaaataccc cagctaaaag tgaaaatgtt gatgttggaa aaccagcttt    660

aggaaaatcc attttagtgc caaacgagga actttcgatg gtgatgagct ctaagaaaaa    720

acttacaaaa aagactgaaa gtcaaagcca aaaacgttca ttgcactcag tatcagaaga    780

acgcacagat gaaatgacac ataaagaaac aaatgagcag gaagaaagat tgctcgccac    840

agcttccttc actaaatcat cccgcagcag caggactcgg tctagcaagg ccatcttgtt    900

gccggacctt tctgaaccaa acaatgagcc tttattttct ccagcgtcag aagttccaag    960

gaaagcaaaa gaaagatgat gcacaatcag tagaaactct gggaaagcca aaagcgaaac   1020

gaatcaggac gtcaaaaaca aaacaagcaa gcaaaaacac agaaaaagaa agtgcttggt   1080

cacctcctcc catagaaatt cggctgattt cccccttggc tagcccagct gacggagtca   1140

agagcaaacc aagaaaaact acagaagtga caggaacagg tcttggaagg aacagaaaga   1200

aactgtcttc ctatccaaag caaattttac gcagaaaaat gctgtaattt cttgggaaga   1260

ttttaatgta cacctatttg taaagtcatc agaatagtgt ggattattaa atatctagtt   1320

tggaagaaaa taatttatat aaattattgt aaatttttat gtaaacagaa ggtcttcaat   1380

aagtaaagta actccatatg gagtgattgt ttcagtccag gcaatttttc tattttatat   1440

taagacttca tacatttata tatgtaaata tggcttatta atggaatgtt aaataaaatg   1500

tatacttcac agtcgtttgt gtcttggatt tttgaaaggg aggggatatc tgtttaaata   1560

gttttatatg ctcattggtc tcattttctc tataattaaa atactagacc agtcttaaaa   1620

tggggatgat tgaagtattg atatttcttt ttacagttac tattttataa tttatgcact   1680

ttgattctgt gattcagatt tctaatcaga aaatgtattt ttttgttttt ggctgttact   1740

atgttaaaat tgaattatgg gcatgtcatt ttgccatctt tgtagtttca caaattttgt   1800

gtaatctacc tcaaatgaat aatccaagta ttggttaact ataatgttgg catctcttat   1860

tcggcaagct taaaggctct ttaaagtctt aattagtcaa agactaatcc aggttagatt   1920

gaccggttca ctgctcactt gcaaccttat caaagggttt gacaaaggga aatgtaaaat   1980

aaatctgttt atggatattg agtgcatctt gtatgtgcct aatattgata ggatgagatg   2040

tctgaacaaa tttttataat attgctgtga aggagcttgc tattgaacca cagaaatccc   2100

ttaatattca ggttttaaaa ctggcaaatt ctcacaggac ctcaggcaca gattattgag   2160

gttgggagag agtgagtaga tgtagaaaag gagaaaaaca acacacgccc tgttctctac   2220

agtacaactg tgtgcaatta agcaatggta cttgatgtag gctctaacac tcatcaataa   2280

ataagtgttg taaaataatt tataacaggt aatcgatagt gtgtaatgaa tggactatta   2340

ataattgatt atctagaaac gaactgcttt cgtgggcttt taatatttta atgtgaagca   2400

tatgcagtgt gctttctgca tttatttttc taccaaataa tacagataat gagaaattgg   2460

tgaaaatgcc tacgcaaagt gttgacagtg tgaaagcagt gcgagtgcgg ccttttagtc   2520

aggttagtga tggatgttac gctgccttgt tgaaaatttc actgactttg attttattac   2580

ttttttaatg atagttatca aacttgtatt taagctgctt gtcatttatg gaatattgaa   2640

cttatttaaa tgaacttgtt aaatgaataa agagctaaac at                      2682


<210>  2167
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  2167

Met Ile Arg Lys Leu Arg Ser Thr Asn Leu Asp Ala Ser Glu Asn Thr 
1               5                   10                  15


Gly Asn Lys Gln Asp Asp Lys Ser Ser Asp Lys Gln Leu Arg Ile Lys 
            20                  25                  30


His Val Arg Arg Val Arg Gly Arg Glu Val Ser Pro Ser Asp Val Arg 
        35                  40                  45


Glu Asp Ser Asn Leu Glu Ser Ser Gln Leu Thr Val Gln Ala Glu Phe 
    50                  55                  60


Asp Met Ser Ala Ile Pro Arg Lys Arg Gly Arg Pro Arg Lys Ile Asn 
65                  70                  75                  80


Pro Ser Glu Asp Val Gly Ser Lys Ala Val Lys Glu Glu Arg Ser Pro 
                85                  90                  95


Lys Lys Lys Glu Ala Pro Ser Ile Arg Arg Arg Ser Thr Arg Asn Thr 
            100                 105                 110


Pro Ala Lys Ser Glu Asn Val Asp Val Gly Lys Pro Ala Leu Gly Lys 
        115                 120                 125


Ser Ile Leu Val Pro Asn Glu Glu Leu Ser Met Val Met Ser Ser Lys 
    130                 135                 140


Lys Lys Leu Thr Lys Lys Thr Glu Ser Gln Ser Gln Lys Arg Ser Leu 
145                 150                 155                 160


His Ser Val Ser Glu Glu Arg Thr Asp Glu Met Thr His Lys Glu Thr 
                165                 170                 175


Asn Glu Gln Glu Glu Arg Leu Leu Ala Thr Ala Ser Phe Thr Lys Ser 
            180                 185                 190


Ser Arg Ser Ser Arg Thr Arg Ser Ser Lys Ala Ile Leu Leu Pro Asp 
        195                 200                 205


Leu Ser Glu Pro Asn Asn Glu Pro Leu Phe Ser Pro Ala Ser Glu Val 
    210                 215                 220


Pro Arg Lys Ala Lys Glu Arg 
225                 230


<210>  2168
<211>  8478
<212>  DNA
<213>  Homo sapiens

<400>  2168
tcgttacata atctcggacc ggaggagcgg cggcacatgg cggcggagcg gcgctggtgg     60

ttcgcgtcct gcgccggcag tcgggtccct ttacggacgg ccggggccgc gaccctttcc    120

cactgttctc ccacgcgatg gactcgttgg cgggcctttc cccgagggaa gcggccggcg    180

tgctgagcct gtcctgtgtt ggcgtgtgtt ccacatgcgc ttgggcctgg ccacatggaa    240

gtatgcgaga cttaagagct caagtgacta gtggtctcct gccatttcca gaagtgactc    300

ttcaagccct tggagaagac gaaataacat tagaatctgt gcttcgtgga aagtttgctg    360

cagggaaaaa tggacttgct tgcttggctt gtggtccaca acttgaggta gtaaactcta    420

taacaggaga gcgattgtct gcttacagat tcagtggagt caatgaacag cctcctgtag    480

ttttagctgt gaaagaattc tcttggcaga agagaactgg attattaata ggattggaag    540

aaacagaagg gagtgttctc tgtctttatg accttggaat atcaaaagta gttaaagcag    600

ttgttcttcc tggaagggta acagctattg aacctataat taatcatgga ggagccagtg    660

caagcactca gcatttacat ccaagtctgc gatggctttt tggagtggca gctgtggtca    720

ctgatgttgg acagatcctt cttgttgacc tatgtttgga tgacttgtca tgcaatcaaa    780

atgaagttga agcatcagat cttgaagttc taactggtat cccagctgaa gtaccacaca    840

ttagagaaag tgtaatgaga caagggcgcc atctgtgttt ccagttagta agtccaacag    900

gaacagctgt ttcaactctt agttacataa gcaggacaaa tcagcttgct gtaggttttt    960

ctgatggcta tctagcactt tggaacatga aaagcatgaa aagagaatat tacatacaat   1020

tggaaagtgg acaagttcct gtatatgctg tcacttttca agaacctgag aatgatcctc   1080

ggaattgctg ttacttgtgg gctgttcagt ctacacaaga tagtgaaggg gatgttttga   1140

gtttgcatct gctgcagctg gcctttggta atagaaagtg tttggcatca ggacaaatct   1200

tatatgaggg gttagaatac tgtgaagaaa gatacaccct ggacctgaca ggtggcatgt   1260

tccctttgag gggacagacg agtaatacca aattgttggg atgccagagt atagagaaat   1320

ttcgatctca tggtgacagg gaggaaggcg tgaatgaagc tctatcgcct gacactagtg   1380

tttcagtctt tacctggcag gtgaatatat atggacaggg aaagccttct gtatatttgg   1440

ggctttttga tataaatcgt tggtatcatg cacaaatgcc agattcgtta aggtcaggag   1500

aatatctaca taattgctct tattttgcac tgtggtcatt ggagtctgtt gtaagtagga   1560

cttctccaca tggcatcttg gatatattag tacatgagag aagtttaaat agaggagtcc   1620

ctccttcata tccacctccc gagcagtttt ttaatccaag cacttataat tttgatgcca   1680

cttgtttgtt aaactcggga gttgttcatt taacttgtac tggctttcag aaggagactt   1740

tgactttttt aaagaaatca ggtccatcac tcaatgaact cattcctgat ggttataatc   1800

gatgtcttgt agctggcctt ctttccccaa gatttgttga tgttcagcct tccagtttaa   1860

gccaagaaga acagttagaa gctatattgt cagcagcaat tcagactagt tccctgggac   1920

ttttgactgg ttatatccga agatggataa cagaagaaca accaaattct gccactaatt   1980

tgcgctttgt tcttgaatgg acgtggaata aagtggttct cacaaaagag gaatttgaca   2040

gactatgtgt gccattattt gatggttcgt gtcatttcat ggatccacaa actatacagt   2100

ctatccagca atgctatttg cttcttagca atcttaatat agtcttgagc tgttttgcat   2160

cagaagcccg agagatcact gagagaggac tgatagactt aagcaataag tttgtggttt   2220

cccacctcat ctgtcagtat gcacaagtgg ttctttggtt ctctcattct gggcttttac   2280

cagaaggcat agatgattct gtgcagttgt caaggttatg ctacaactac cctgtaattc   2340

agaactacta caccagtcgt cgacagaagt ttgagcgttt atcaagaggg aagtggaatc   2400

ccgattgctt gatgattgat ggactggttt ctcagttagg agagcgaatt gagaagttgt   2460

ggaaacgaga tgaaggaggc acaggaaaat atcctcctgc tagtctgcat gcagtacttg   2520

atatgtacct attagacggc gttactgaag cagccaaaca ctctattacc atttatttgc   2580

tacttgatat tatgtattcc tttcccaaca aaacagacac tcccattgaa tctttcccaa   2640

ctgtatttgc catttcttgg ggccaagtta aacttattca ggggttttgg ttgatagatc   2700

ataatgacta tgagagtggt ttggatcttt tgtttcatcc agctactgca aaacctttgt   2760

catggcaaca ttcaaagatt attcaggcat tcatgagtca gggcgagcac agacaagccc   2820

tcagatatat tcagacaatg aagccaacag tgtccagtgg taacgatgtt atccttcacc   2880

tcactgtttt gctttttaat aggtgtatgg ttgaagcctg gaattttttg cggcaacatt   2940

gcaataggtt gaatatagag gagttactga agcacatgta tgaagtctgt caggaaatgg   3000

gcttgatgga agatttactg aagttaccat ttacagacac tgagcaggaa tgtttagtga   3060

aatttttgca gtccagtgcc agcgttcaga atcatgaatt ccttttagtg caccatttgc   3120

agcgtgccaa ttatgtgcct gccttgaagc tgaaccaaac tctgaagatt aatgttatga   3180

atgatcgtga tcctcgtttg cgggagagat cactggctcg aaattctata ttagaccagt   3240

atggaaaaat ccttcctaga gtccatcgaa aattagccat tgaacgagct aagccttatc   3300

atctgtcaac atcatcagtt tttcgattag tttctagacc caaaccatta tcagcagttc   3360

caaagcaagt tgtaacagga actgtgttga caagatctgt tttcatcaac aatgtgttat   3420

ctaaaattgg agaagtttgg gcaagcaaag aacctataaa tagcaccaca cctttcaata   3480

gttctaaaat agaagaacca tctcctatag tgtattcgct cccagctcca gagctgcctg   3540

aggcattttt tggaacacca atttcaaaag catcacaaaa aatttctaga ctgctagatt   3600

tggttgttca gcctgtcccc cggccttctc agtgttcgga gtttattcag caaagctcca   3660

tgaaatctcc tttgtaccta gtatcccgtt cactgccctc aagttcgcaa ttaaaaggat   3720

cgcctcaggc catctccagg gcttcagaat tacatttgct tgaaactcct cttgtagtta   3780

agaaagctaa aagtttggcc atgtcagtta ctacttctgg attttctgag ttcactcctc   3840

agtccatcct gaggtctact cttcgatcaa cacctttagc atctccctct ccatcacctg   3900

gaaggtctcc tcaacgactt aaagaaacta gaatttcatt tgtggaagaa gatgtccacc   3960

caaaatggat tcctggggct gcagatgata gcaaattaga agtatttact acacctaaaa   4020

aatgtgcagt tccagtggaa actgaatggc tgaagagcaa agataggacc acatcttttt   4080

tcctgaacag ccctgaaaag gagcatcaag aaatggatga ggggtcacaa agtttagaga   4140

aactggatgt gagcaaagga aacagcagtg tttcaatcac atccgatgag actaccttag   4200

agtatcagga tgcaccgtca ccggaagacc ttgaagagac tgttttcacg gcctctaagc   4260

ccaaaagctc ttccactgca ctaactacta atgtaactga acaaactgaa aaggatggag   4320

ataaagatgt atttgcatca gaagtaactc cttcagacct acagaaacaa atgggcaatt   4380

tagaagatgc agaaacaaag gatctcttag ttgcagcaga ggcattttca gaattgaatc   4440

acttaagccc ggttcaagga actgaagctt ctctttgtgc accatcagtc tatgaaggga   4500

aaatcttcac ccagaagtcc aaggtaccag tgttggacga aggattaaca tctgttgaaa   4560

cctacacccc tgcaattaga gcaaatgaca ataaatctat ggctgatgtc cttggtgatg   4620

gtggaaactc ctcgctcact atctctgaag gtcctattgt ctctgagcgc aggcttaacc   4680

aggaagtagc gctgaactta aaagaagatc atgaagtaga agttggtgta ctaaaagaaa   4740

gtgttgactt accagaagaa aagcttccaa tttctgacag ccctcctgat actcaagaaa   4800

ttcatgtgat tgaacaagaa aagcttgaag ctcaagattc aggagaagag gctaggaatc   4860

tttcatttaa tgagttatat ccctctggaa cacttaagct tcagtacaat tttgatacta   4920

ttgaccaaca gttttgtgac ttagctgata acaaagacac tgctgaatgt gacattgctg   4980

aagtagatgg ggaacttttt gtggctcaaa gcaactttac cttgatattg gaaggtgaag   5040

aaggagaagt tgagccaggt gattttgcat catctgatgt gttacctaaa gcagctaaca   5100

cagcaactga agaaaaactt gtatgcagtg gggaaaatga taatcatgga caaattgcaa   5160

atttgccatc tgccgtaact agtgaccaaa agtcccaaaa agtagacact ttaccatatg   5220

tgcctgaacc tattaaagta gcaattgcag aaaatttact agatgtaatt aaagacacaa   5280

gaagtaaaga aattacttca gatacaatgg aacagtccat tcatgaaaca atacctttag   5340

tgagccaaaa cataatgtgt cccactaaat tggtcaaatc tgcatttaag actgctcagg   5400

aaacaagcac aatgactatg aatgtcagcc aggttgatga cgtggtttcc tccaaaactc   5460

gtacgagagg tcaacgtatc caaaacgtga atgtcaaatc agcacaacag gaagcatcag   5520

cagatgttgc tactcctaag atgccagggc agtcagtcag gaagaaaact aggaaggcaa   5580

aagaaatttc tgaagcttct gaaaacatct attctgatgt cagaggacta tctcagaacc   5640

agcaaatacc tcaaaattct gttacgccta ggagaggaag gagaaagaaa gaagttaatc   5700

aggacatact agaaaacacc agttctgtgg aacaagaatt acagatcact acaggtaggg   5760

aatcaaaaag attaaaatca tctcagctgt tggaaccagc agttgaagaa actactaaaa   5820

aagaagttaa ggtttcatct gttacaaaaa ggactcctag aagaattaaa agatctgtag   5880

aaaatcagga aagtgttgaa attataaatg atctaaaagt tagtacggta acaagtccta   5940

gcagaatgat cagaaaattg agaagtacta atttagatgc ttctgaaaat acaggaaata   6000

agcaagatga taaatccagt gacaagcagc tgcgtattaa acatgttaga agggtcagag   6060

ggagagaagt tagtccatca gatgtgagag aagactccaa ccttgagtca tctcagttga   6120

ctgttcaagc agaatttgat atgtctgcca tacctagaaa acgtggtaga ccaagaaaaa   6180

tcaatccatc tgaagatgta ggatctaagg ctgttaagga agagagaagc cccaagaaga   6240

aagaagctcc cagcattaga aggagatcta caagaaatac cccagctaaa agtgaaaatg   6300

ttgatgttgg aaaaccagct ttaggaaaat ccattttagt gccaaacgag gaactttcga   6360

tggtgatgag ctctaagaaa aaacttacaa aaaagactga aagtcaaagc caaaaacgtt   6420

cattgcactc agtatcagaa gaacgcacag atgaaatgac acataaagaa acaaatgagc   6480

aggaagaaag attgctcgcc acagcttcct tcactaaatc atcccgcagc agcaggactc   6540

ggtctagcaa ggccatcttg ttgccggacc tttctgaacc aaacaatgag cctttatttt   6600

ctccagcgtc agaagttcca aggaaagcaa aagctaaaaa aatagaggtt cctgcacagc   6660

tgaaagaatt agtttcggat ttatcttctc agtttgtcat ctcacctcct gctttaagga   6720

gcagacaaaa aaacacatcc aataagaaca agcttgaaga tgaactgaaa gatgatgcac   6780

aatcagtaga aactctggga aagccaaaag cgaaacgaat caggacgtca aaaacaaaac   6840

aagcaagcaa aaacacagaa aaagaaagtg cttggtcacc tcctcccata gaaattcggc   6900

tgatttcccc cttggctagc ccagctgacg gagtcaagag caaaccaaga aaaactacag   6960

aagtgacagg aacaggtctt ggaaggaaca gaaagaaact gtcttcctat ccaaagcaaa   7020

ttttacgcag aaaaatgctg taatttcttg ggaagatttt aatgtacacc tatttgtaaa   7080

gtcatcagaa tagtgtggat tattaaatat ctagtttgga agaaaataat ttatataaat   7140

tattgtaaat ttttatgtaa acagaaggtc ttcaataagt aaagtaactc catatggagt   7200

gattgtttca gtccaggcaa tttttctatt ttatattaag acttcataca tttatatatg   7260

taaatatggc ttattaatgg aatgttaaat aaaatgtata cttcacagtc gtttgtgtct   7320

tggatttttg aaagggaggg gatatctgtt taaatagttt tatatgctca ttggtctcat   7380

tttctctata attaaaatac tagaccagtc ttaaaatggg gatgattgaa gtattgatat   7440

ttctttttac agttactatt ttataattta tgcactttga ttctgtgatt cagatttcta   7500

atcagaaaat gtattttttt gtttttggct gttactatgt taaaattgaa ttatgggcat   7560

gtcattttgc catctttgta gtttcacaaa ttttgtgtaa tctacctcaa atgaataatc   7620

caagtattgg ttaactataa tgttggcatc tcttattcgg caagcttaaa ggctctttaa   7680

agtcttaatt agtcaaagac taatccaggt tagattgacc ggttcactgc tcacttgcaa   7740

ccttatcaaa gggtttgaca aagggaaatg taaaataaat ctgtttatgg atattgagtg   7800

catcttgtat gtgcctaata ttgataggat gagatgtctg aacaaatttt tataatattg   7860

ctgtgaagga gcttgctatt gaaccacaga aatcccttaa tattcaggtt ttaaaactgg   7920

caaattctca caggacctca ggcacagatt attgaggttg ggagagagtg agtagatgta   7980

gaaaaggaga aaaacaacac acgccctgtt ctctacagta caactgtgtg caattaagca   8040

atggtacttg atgtaggctc taacactcat caataaataa gtgttgtaaa ataatttata   8100

acaggtaatc gatagtgtgt aatgaatgga ctattaataa ttgattatct agaaacgaac   8160

tgctttcgtg ggcttttaat attttaatgt gaagcatatg cagtgtgctt tctgcattta   8220

tttttctacc aaataataca gataatgaga aattggtgaa aatgcctacg caaagtgttg   8280

acagtgtgaa agcagtgcga gtgcggcctt ttagtcaggt tagtgatgga tgttacgctg   8340

ccttgttgaa aatttcactg actttgattt tattactttt ttaatgatag ttatcaaact   8400

tgtatttaag ctgcttgtca tttatggaat attgaactta tttaaatgaa cttgttaaat   8460

gaataaagag ctaaacat                                                 8478


<210>  2169
<211>  2301
<212>  PRT
<213>  Homo sapiens

<400>  2169

Met Asp Ser Leu Ala Gly Leu Ser Pro Arg Glu Ala Ala Gly Val Leu 
1               5                   10                  15


Ser Leu Ser Cys Val Gly Val Cys Ser Thr Cys Ala Trp Ala Trp Pro 
            20                  25                  30


His Gly Ser Met Arg Asp Leu Arg Ala Gln Val Thr Ser Gly Leu Leu 
        35                  40                  45


Pro Phe Pro Glu Val Thr Leu Gln Ala Leu Gly Glu Asp Glu Ile Thr 
    50                  55                  60


Leu Glu Ser Val Leu Arg Gly Lys Phe Ala Ala Gly Lys Asn Gly Leu 
65                  70                  75                  80


Ala Cys Leu Ala Cys Gly Pro Gln Leu Glu Val Val Asn Ser Ile Thr 
                85                  90                  95


Gly Glu Arg Leu Ser Ala Tyr Arg Phe Ser Gly Val Asn Glu Gln Pro 
            100                 105                 110


Pro Val Val Leu Ala Val Lys Glu Phe Ser Trp Gln Lys Arg Thr Gly 
        115                 120                 125


Leu Leu Ile Gly Leu Glu Glu Thr Glu Gly Ser Val Leu Cys Leu Tyr 
    130                 135                 140


Asp Leu Gly Ile Ser Lys Val Val Lys Ala Val Val Leu Pro Gly Arg 
145                 150                 155                 160


Val Thr Ala Ile Glu Pro Ile Ile Asn His Gly Gly Ala Ser Ala Ser 
                165                 170                 175


Thr Gln His Leu His Pro Ser Leu Arg Trp Leu Phe Gly Val Ala Ala 
            180                 185                 190


Val Val Thr Asp Val Gly Gln Ile Leu Leu Val Asp Leu Cys Leu Asp 
        195                 200                 205


Asp Leu Ser Cys Asn Gln Asn Glu Val Glu Ala Ser Asp Leu Glu Val 
    210                 215                 220


Leu Thr Gly Ile Pro Ala Glu Val Pro His Ile Arg Glu Ser Val Met 
225                 230                 235                 240


Arg Gln Gly Arg His Leu Cys Phe Gln Leu Val Ser Pro Thr Gly Thr 
                245                 250                 255


Ala Val Ser Thr Leu Ser Tyr Ile Ser Arg Thr Asn Gln Leu Ala Val 
            260                 265                 270


Gly Phe Ser Asp Gly Tyr Leu Ala Leu Trp Asn Met Lys Ser Met Lys 
        275                 280                 285


Arg Glu Tyr Tyr Ile Gln Leu Glu Ser Gly Gln Val Pro Val Tyr Ala 
    290                 295                 300


Val Thr Phe Gln Glu Pro Glu Asn Asp Pro Arg Asn Cys Cys Tyr Leu 
305                 310                 315                 320


Trp Ala Val Gln Ser Thr Gln Asp Ser Glu Gly Asp Val Leu Ser Leu 
                325                 330                 335


His Leu Leu Gln Leu Ala Phe Gly Asn Arg Lys Cys Leu Ala Ser Gly 
            340                 345                 350


Gln Ile Leu Tyr Glu Gly Leu Glu Tyr Cys Glu Glu Arg Tyr Thr Leu 
        355                 360                 365


Asp Leu Thr Gly Gly Met Phe Pro Leu Arg Gly Gln Thr Ser Asn Thr 
    370                 375                 380


Lys Leu Leu Gly Cys Gln Ser Ile Glu Lys Phe Arg Ser His Gly Asp 
385                 390                 395                 400


Arg Glu Glu Gly Val Asn Glu Ala Leu Ser Pro Asp Thr Ser Val Ser 
                405                 410                 415


Val Phe Thr Trp Gln Val Asn Ile Tyr Gly Gln Gly Lys Pro Ser Val 
            420                 425                 430


Tyr Leu Gly Leu Phe Asp Ile Asn Arg Trp Tyr His Ala Gln Met Pro 
        435                 440                 445


Asp Ser Leu Arg Ser Gly Glu Tyr Leu His Asn Cys Ser Tyr Phe Ala 
    450                 455                 460


Leu Trp Ser Leu Glu Ser Val Val Ser Arg Thr Ser Pro His Gly Ile 
465                 470                 475                 480


Leu Asp Ile Leu Val His Glu Arg Ser Leu Asn Arg Gly Val Pro Pro 
                485                 490                 495


Ser Tyr Pro Pro Pro Glu Gln Phe Phe Asn Pro Ser Thr Tyr Asn Phe 
            500                 505                 510


Asp Ala Thr Cys Leu Leu Asn Ser Gly Val Val His Leu Thr Cys Thr 
        515                 520                 525


Gly Phe Gln Lys Glu Thr Leu Thr Phe Leu Lys Lys Ser Gly Pro Ser 
    530                 535                 540


Leu Asn Glu Leu Ile Pro Asp Gly Tyr Asn Arg Cys Leu Val Ala Gly 
545                 550                 555                 560


Leu Leu Ser Pro Arg Phe Val Asp Val Gln Pro Ser Ser Leu Ser Gln 
                565                 570                 575


Glu Glu Gln Leu Glu Ala Ile Leu Ser Ala Ala Ile Gln Thr Ser Ser 
            580                 585                 590


Leu Gly Leu Leu Thr Gly Tyr Ile Arg Arg Trp Ile Thr Glu Glu Gln 
        595                 600                 605


Pro Asn Ser Ala Thr Asn Leu Arg Phe Val Leu Glu Trp Thr Trp Asn 
    610                 615                 620


Lys Val Val Leu Thr Lys Glu Glu Phe Asp Arg Leu Cys Val Pro Leu 
625                 630                 635                 640


Phe Asp Gly Ser Cys His Phe Met Asp Pro Gln Thr Ile Gln Ser Ile 
                645                 650                 655


Gln Gln Cys Tyr Leu Leu Leu Ser Asn Leu Asn Ile Val Leu Ser Cys 
            660                 665                 670


Phe Ala Ser Glu Ala Arg Glu Ile Thr Glu Arg Gly Leu Ile Asp Leu 
        675                 680                 685


Ser Asn Lys Phe Val Val Ser His Leu Ile Cys Gln Tyr Ala Gln Val 
    690                 695                 700


Val Leu Trp Phe Ser His Ser Gly Leu Leu Pro Glu Gly Ile Asp Asp 
705                 710                 715                 720


Ser Val Gln Leu Ser Arg Leu Cys Tyr Asn Tyr Pro Val Ile Gln Asn 
                725                 730                 735


Tyr Tyr Thr Ser Arg Arg Gln Lys Phe Glu Arg Leu Ser Arg Gly Lys 
            740                 745                 750


Trp Asn Pro Asp Cys Leu Met Ile Asp Gly Leu Val Ser Gln Leu Gly 
        755                 760                 765


Glu Arg Ile Glu Lys Leu Trp Lys Arg Asp Glu Gly Gly Thr Gly Lys 
    770                 775                 780


Tyr Pro Pro Ala Ser Leu His Ala Val Leu Asp Met Tyr Leu Leu Asp 
785                 790                 795                 800


Gly Val Thr Glu Ala Ala Lys His Ser Ile Thr Ile Tyr Leu Leu Leu 
                805                 810                 815


Asp Ile Met Tyr Ser Phe Pro Asn Lys Thr Asp Thr Pro Ile Glu Ser 
            820                 825                 830


Phe Pro Thr Val Phe Ala Ile Ser Trp Gly Gln Val Lys Leu Ile Gln 
        835                 840                 845


Gly Phe Trp Leu Ile Asp His Asn Asp Tyr Glu Ser Gly Leu Asp Leu 
    850                 855                 860


Leu Phe His Pro Ala Thr Ala Lys Pro Leu Ser Trp Gln His Ser Lys 
865                 870                 875                 880


Ile Ile Gln Ala Phe Met Ser Gln Gly Glu His Arg Gln Ala Leu Arg 
                885                 890                 895


Tyr Ile Gln Thr Met Lys Pro Thr Val Ser Ser Gly Asn Asp Val Ile 
            900                 905                 910


Leu His Leu Thr Val Leu Leu Phe Asn Arg Cys Met Val Glu Ala Trp 
        915                 920                 925


Asn Phe Leu Arg Gln His Cys Asn Arg Leu Asn Ile Glu Glu Leu Leu 
    930                 935                 940


Lys His Met Tyr Glu Val Cys Gln Glu Met Gly Leu Met Glu Asp Leu 
945                 950                 955                 960


Leu Lys Leu Pro Phe Thr Asp Thr Glu Gln Glu Cys Leu Val Lys Phe 
                965                 970                 975


Leu Gln Ser Ser Ala Ser Val Gln Asn His Glu Phe Leu Leu Val His 
            980                 985                 990


His Leu Gln Arg Ala Asn Tyr Val Pro Ala Leu Lys Leu Asn Gln Thr 
        995                 1000                1005


Leu Lys Ile Asn Val Met Asn Asp Arg Asp Pro Arg Leu Arg Glu Arg 
    1010                1015                1020


Ser Leu Ala Arg Asn Ser Ile Leu Asp Gln Tyr Gly Lys Ile Leu Pro 
1025                1030                1035                1040


Arg Val His Arg Lys Leu Ala Ile Glu Arg Ala Lys Pro Tyr His Leu 
                1045                1050                1055


Ser Thr Ser Ser Val Phe Arg Leu Val Ser Arg Pro Lys Pro Leu Ser 
            1060                1065                1070


Ala Val Pro Lys Gln Val Val Thr Gly Thr Val Leu Thr Arg Ser Val 
        1075                1080                1085


Phe Ile Asn Asn Val Leu Ser Lys Ile Gly Glu Val Trp Ala Ser Lys 
    1090                1095                1100


Glu Pro Ile Asn Ser Thr Thr Pro Phe Asn Ser Ser Lys Ile Glu Glu 
1105                1110                1115                1120


Pro Ser Pro Ile Val Tyr Ser Leu Pro Ala Pro Glu Leu Pro Glu Ala 
                1125                1130                1135


Phe Phe Gly Thr Pro Ile Ser Lys Ala Ser Gln Lys Ile Ser Arg Leu 
            1140                1145                1150


Leu Asp Leu Val Val Gln Pro Val Pro Arg Pro Ser Gln Cys Ser Glu 
        1155                1160                1165


Phe Ile Gln Gln Ser Ser Met Lys Ser Pro Leu Tyr Leu Val Ser Arg 
    1170                1175                1180


Ser Leu Pro Ser Ser Ser Gln Leu Lys Gly Ser Pro Gln Ala Ile Ser 
1185                1190                1195                1200


Arg Ala Ser Glu Leu His Leu Leu Glu Thr Pro Leu Val Val Lys Lys 
                1205                1210                1215


Ala Lys Ser Leu Ala Met Ser Val Thr Thr Ser Gly Phe Ser Glu Phe 
            1220                1225                1230


Thr Pro Gln Ser Ile Leu Arg Ser Thr Leu Arg Ser Thr Pro Leu Ala 
        1235                1240                1245


Ser Pro Ser Pro Ser Pro Gly Arg Ser Pro Gln Arg Leu Lys Glu Thr 
    1250                1255                1260


Arg Ile Ser Phe Val Glu Glu Asp Val His Pro Lys Trp Ile Pro Gly 
1265                1270                1275                1280


Ala Ala Asp Asp Ser Lys Leu Glu Val Phe Thr Thr Pro Lys Lys Cys 
                1285                1290                1295


Ala Val Pro Val Glu Thr Glu Trp Leu Lys Ser Lys Asp Arg Thr Thr 
            1300                1305                1310


Ser Phe Phe Leu Asn Ser Pro Glu Lys Glu His Gln Glu Met Asp Glu 
        1315                1320                1325


Gly Ser Gln Ser Leu Glu Lys Leu Asp Val Ser Lys Gly Asn Ser Ser 
    1330                1335                1340


Val Ser Ile Thr Ser Asp Glu Thr Thr Leu Glu Tyr Gln Asp Ala Pro 
1345                1350                1355                1360


Ser Pro Glu Asp Leu Glu Glu Thr Val Phe Thr Ala Ser Lys Pro Lys 
                1365                1370                1375


Ser Ser Ser Thr Ala Leu Thr Thr Asn Val Thr Glu Gln Thr Glu Lys 
            1380                1385                1390


Asp Gly Asp Lys Asp Val Phe Ala Ser Glu Val Thr Pro Ser Asp Leu 
        1395                1400                1405


Gln Lys Gln Met Gly Asn Leu Glu Asp Ala Glu Thr Lys Asp Leu Leu 
    1410                1415                1420


Val Ala Ala Glu Ala Phe Ser Glu Leu Asn His Leu Ser Pro Val Gln 
1425                1430                1435                1440


Gly Thr Glu Ala Ser Leu Cys Ala Pro Ser Val Tyr Glu Gly Lys Ile 
                1445                1450                1455


Phe Thr Gln Lys Ser Lys Val Pro Val Leu Asp Glu Gly Leu Thr Ser 
            1460                1465                1470


Val Glu Thr Tyr Thr Pro Ala Ile Arg Ala Asn Asp Asn Lys Ser Met 
        1475                1480                1485


Ala Asp Val Leu Gly Asp Gly Gly Asn Ser Ser Leu Thr Ile Ser Glu 
    1490                1495                1500


Gly Pro Ile Val Ser Glu Arg Arg Leu Asn Gln Glu Val Ala Leu Asn 
1505                1510                1515                1520


Leu Lys Glu Asp His Glu Val Glu Val Gly Val Leu Lys Glu Ser Val 
                1525                1530                1535


Asp Leu Pro Glu Glu Lys Leu Pro Ile Ser Asp Ser Pro Pro Asp Thr 
            1540                1545                1550


Gln Glu Ile His Val Ile Glu Gln Glu Lys Leu Glu Ala Gln Asp Ser 
        1555                1560                1565


Gly Glu Glu Ala Arg Asn Leu Ser Phe Asn Glu Leu Tyr Pro Ser Gly 
    1570                1575                1580


Thr Leu Lys Leu Gln Tyr Asn Phe Asp Thr Ile Asp Gln Gln Phe Cys 
1585                1590                1595                1600


Asp Leu Ala Asp Asn Lys Asp Thr Ala Glu Cys Asp Ile Ala Glu Val 
                1605                1610                1615


Asp Gly Glu Leu Phe Val Ala Gln Ser Asn Phe Thr Leu Ile Leu Glu 
            1620                1625                1630


Gly Glu Glu Gly Glu Val Glu Pro Gly Asp Phe Ala Ser Ser Asp Val 
        1635                1640                1645


Leu Pro Lys Ala Ala Asn Thr Ala Thr Glu Glu Lys Leu Val Cys Ser 
    1650                1655                1660


Gly Glu Asn Asp Asn His Gly Gln Ile Ala Asn Leu Pro Ser Ala Val 
1665                1670                1675                1680


Thr Ser Asp Gln Lys Ser Gln Lys Val Asp Thr Leu Pro Tyr Val Pro 
                1685                1690                1695


Glu Pro Ile Lys Val Ala Ile Ala Glu Asn Leu Leu Asp Val Ile Lys 
            1700                1705                1710


Asp Thr Arg Ser Lys Glu Ile Thr Ser Asp Thr Met Glu Gln Ser Ile 
        1715                1720                1725


His Glu Thr Ile Pro Leu Val Ser Gln Asn Ile Met Cys Pro Thr Lys 
    1730                1735                1740


Leu Val Lys Ser Ala Phe Lys Thr Ala Gln Glu Thr Ser Thr Met Thr 
1745                1750                1755                1760


Met Asn Val Ser Gln Val Asp Asp Val Val Ser Ser Lys Thr Arg Thr 
                1765                1770                1775


Arg Gly Gln Arg Ile Gln Asn Val Asn Val Lys Ser Ala Gln Gln Glu 
            1780                1785                1790


Ala Ser Ala Asp Val Ala Thr Pro Lys Met Pro Gly Gln Ser Val Arg 
        1795                1800                1805


Lys Lys Thr Arg Lys Ala Lys Glu Ile Ser Glu Ala Ser Glu Asn Ile 
    1810                1815                1820


Tyr Ser Asp Val Arg Gly Leu Ser Gln Asn Gln Gln Ile Pro Gln Asn 
1825                1830                1835                1840


Ser Val Thr Pro Arg Arg Gly Arg Arg Lys Lys Glu Val Asn Gln Asp 
                1845                1850                1855


Ile Leu Glu Asn Thr Ser Ser Val Glu Gln Glu Leu Gln Ile Thr Thr 
            1860                1865                1870


Gly Arg Glu Ser Lys Arg Leu Lys Ser Ser Gln Leu Leu Glu Pro Ala 
        1875                1880                1885


Val Glu Glu Thr Thr Lys Lys Glu Val Lys Val Ser Ser Val Thr Lys 
    1890                1895                1900


Arg Thr Pro Arg Arg Ile Lys Arg Ser Val Glu Asn Gln Glu Ser Val 
1905                1910                1915                1920


Glu Ile Ile Asn Asp Leu Lys Val Ser Thr Val Thr Ser Pro Ser Arg 
                1925                1930                1935


Met Ile Arg Lys Leu Arg Ser Thr Asn Leu Asp Ala Ser Glu Asn Thr 
            1940                1945                1950


Gly Asn Lys Gln Asp Asp Lys Ser Ser Asp Lys Gln Leu Arg Ile Lys 
        1955                1960                1965


His Val Arg Arg Val Arg Gly Arg Glu Val Ser Pro Ser Asp Val Arg 
    1970                1975                1980


Glu Asp Ser Asn Leu Glu Ser Ser Gln Leu Thr Val Gln Ala Glu Phe 
1985                1990                1995                2000


Asp Met Ser Ala Ile Pro Arg Lys Arg Gly Arg Pro Arg Lys Ile Asn 
                2005                2010                2015


Pro Ser Glu Asp Val Gly Ser Lys Ala Val Lys Glu Glu Arg Ser Pro 
            2020                2025                2030


Lys Lys Lys Glu Ala Pro Ser Ile Arg Arg Arg Ser Thr Arg Asn Thr 
        2035                2040                2045


Pro Ala Lys Ser Glu Asn Val Asp Val Gly Lys Pro Ala Leu Gly Lys 
    2050                2055                2060


Ser Ile Leu Val Pro Asn Glu Glu Leu Ser Met Val Met Ser Ser Lys 
2065                2070                2075                2080


Lys Lys Leu Thr Lys Lys Thr Glu Ser Gln Ser Gln Lys Arg Ser Leu 
                2085                2090                2095


His Ser Val Ser Glu Glu Arg Thr Asp Glu Met Thr His Lys Glu Thr 
            2100                2105                2110


Asn Glu Gln Glu Glu Arg Leu Leu Ala Thr Ala Ser Phe Thr Lys Ser 
        2115                2120                2125


Ser Arg Ser Ser Arg Thr Arg Ser Ser Lys Ala Ile Leu Leu Pro Asp 
    2130                2135                2140


Leu Ser Glu Pro Asn Asn Glu Pro Leu Phe Ser Pro Ala Ser Glu Val 
2145                2150                2155                2160


Pro Arg Lys Ala Lys Ala Lys Lys Ile Glu Val Pro Ala Gln Leu Lys 
                2165                2170                2175


Glu Leu Val Ser Asp Leu Ser Ser Gln Phe Val Ile Ser Pro Pro Ala 
            2180                2185                2190


Leu Arg Ser Arg Gln Lys Asn Thr Ser Asn Lys Asn Lys Leu Glu Asp 
        2195                2200                2205


Glu Leu Lys Asp Asp Ala Gln Ser Val Glu Thr Leu Gly Lys Pro Lys 
    2210                2215                2220


Ala Lys Arg Ile Arg Thr Ser Lys Thr Lys Gln Ala Ser Lys Asn Thr 
2225                2230                2235                2240


Glu Lys Glu Ser Ala Trp Ser Pro Pro Pro Ile Glu Ile Arg Leu Ile 
                2245                2250                2255


Ser Pro Leu Ala Ser Pro Ala Asp Gly Val Lys Ser Lys Pro Arg Lys 
            2260                2265                2270


Thr Thr Glu Val Thr Gly Thr Gly Leu Gly Arg Asn Arg Lys Lys Leu 
        2275                2280                2285


Ser Ser Tyr Pro Lys Gln Ile Leu Arg Arg Lys Met Leu 
    2290                2295                2300


<210>  2170
<211>  1514
<212>  DNA
<213>  Homo sapiens

<400>  2170
tacgcctagg agaggaagga gaaagaaaga agttaatcag gacatactag aaaacaccag     60

ttctgtggaa caagaattac agatcactac aggtagggaa tcaaaaagat taaaatcatc    120

tcagctgttg gaaccagcag ttgaagaaac tactaaaaaa gaagttaagg tttcatctgt    180

tacaaaaagg actcctagaa gaattaaaag atctgtagaa aatcaggaaa gtgttgaaat    240

tataaatgat ctaaaagtta gtacggtaac aagtcctagc agaatgatca gaaaattgag    300

aagtactaat ttagatgctt ctgaaaatac aggaaataag caagatgata aatccagtga    360

caagcagctg cgtattaaac atgttagaag ggtcagaggg agagaagtta gtccatcaga    420

tgtgagagaa gactccaacc ttgagtcatc tcagttgact gttcaagcag aatttgatat    480

gtctgccata cctagaaaac gtggtagacc aagaaaaatc aatccatctg aagatgtagg    540

atctaaggct gttaaggaag agagaagccc caagaagaaa gaagctccca gcattagaag    600

gagatctaca agaaataccc cagctaaaag tgaaaatgtt gatgttggaa aaccagcttt    660

aggaaaatcc attttagtgc caaacgagga actttcgatg gtgatgagct ctaagaaaaa    720

acttacaaaa aagactgaaa gtcaaagcca aaaacgttca ttgcactcag tatcagaaga    780

acgcacagat gaaatgacac ataaagaaac aaatgagcag gaagaaagat tgctcgccac    840

agcttccttc actaaatcat cccgcagcag caggactcgg tctagcaagg ccatcttgtt    900

gccggacctt tctgaaccaa acaatgagcc tttattttct ccagcgtcag aagttccaag    960

gaaagcaaaa gaaagatgat gcacaatcag tagaaactct gggaaagcca aaagcgaaac   1020

gaatcaggac gtcaaaaaca aaacaagcaa gcaaaaacac agaaaaagaa agtgcttggt   1080

cacctcctcc catagaaatt cggctgattt cccccttggc tagcccagct gacggagtca   1140

agagcaaacc aagaaaaact acagaagtga caggaacagg tcttggaagg aacagaaaga   1200

aactgtcttc ctatccaaag caaattttac gcagaaaaat gctgtaattt cttgggaaga   1260

ttttaatgta cacctatttg taaagtcatc agaatagtgt ggattattaa atatctagtt   1320

tggaagaaaa taatttatat aaattattgt aaatttttat gtaaacagaa ggtcttcaat   1380

aagtaaagta actccatatg gagtgattgt ttcagtccag gcaatttttc tattttatat   1440

taagacttca tacatttata tatgtaaata tggcttatta atggaatgtt aaataaaatg   1500

tatacttcac agtc                                                     1514


<210>  2171
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  2171

Met Ile Arg Lys Leu Arg Ser Thr Asn Leu Asp Ala Ser Glu Asn Thr 
1               5                   10                  15


Gly Asn Lys Gln Asp Asp Lys Ser Ser Asp Lys Gln Leu Arg Ile Lys 
            20                  25                  30


His Val Arg Arg Val Arg Gly Arg Glu Val Ser Pro Ser Asp Val Arg 
        35                  40                  45


Glu Asp Ser Asn Leu Glu Ser Ser Gln Leu Thr Val Gln Ala Glu Phe 
    50                  55                  60


Asp Met Ser Ala Ile Pro Arg Lys Arg Gly Arg Pro Arg Lys Ile Asn 
65                  70                  75                  80


Pro Ser Glu Asp Val Gly Ser Lys Ala Val Lys Glu Glu Arg Ser Pro 
                85                  90                  95


Lys Lys Lys Glu Ala Pro Ser Ile Arg Arg Arg Ser Thr Arg Asn Thr 
            100                 105                 110


Pro Ala Lys Ser Glu Asn Val Asp Val Gly Lys Pro Ala Leu Gly Lys 
        115                 120                 125


Ser Ile Leu Val Pro Asn Glu Glu Leu Ser Met Val Met Ser Ser Lys 
    130                 135                 140


Lys Lys Leu Thr Lys Lys Thr Glu Ser Gln Ser Gln Lys Arg Ser Leu 
145                 150                 155                 160


His Ser Val Ser Glu Glu Arg Thr Asp Glu Met Thr His Lys Glu Thr 
                165                 170                 175


Asn Glu Gln Glu Glu Arg Leu Leu Ala Thr Ala Ser Phe Thr Lys Ser 
            180                 185                 190


Ser Arg Ser Ser Arg Thr Arg Ser Ser Lys Ala Ile Leu Leu Pro Asp 
        195                 200                 205


Leu Ser Glu Pro Asn Asn Glu Pro Leu Phe Ser Pro Ala Ser Glu Val 
    210                 215                 220


Pro Arg Lys Ala Lys Glu Arg 
225                 230


<210>  2172
<211>  7192
<212>  DNA
<213>  Homo sapiens

<400>  2172
tggggctcga gggggcgagc ggtggcggtg gcgggtacgg caggctcgcg ggcgccgggc     60

ttcgttacat aatctcggac cggaggagcg gcggcacatg gcggcggagc ggcgctgtgg    120

aagtatgcga gacttaagag ctcaagtgac tagtggtctc ctgccatttc cagaagtgac    180

tcttcaagcc cttggagaag acgaaataac attagaatct gtgcttcgtg gaaagtttgc    240

tgcagggaaa aatggacttg cttgcttggc ttgtggtcca caacttgagg tagtaaactc    300

tataacagga gagcgattgt ctgcttacag attcagtgga gtcaatgaac agcctcctgt    360

agttttagct gtgaaagaat tctcttggca gaagagaact ggattattaa taggattgga    420

agaaacagaa gggagtgttc tctgtcttta tgaccttgga atatcaaaag tagttaaagc    480

agttgttctt cctggaaggg taacagctat tgaacctata attaatcatg gaggagccag    540

tgcaagcact cagcatttac atccaagtct gcgatggctt tttggagtgg cagctgtggt    600

cactgatgtt ggacagatcc ttcttgttga cctatgtttg gatgacttgt catgcaatca    660

aaatgaagtt gaagcatcag atcttgaagt tctaactggt atcccagctg aagtaccaca    720

cattagagaa agtgtaatga gacaagggcg ccatctgtgt ttccagttag taagtccaac    780

aggaacagct gtttcaactc ttagttacat aagcaggaca aatcagcttg ctgtaggttt    840

ttctgatggc tatctagcac tttggaacat gaaaagcatg aaaagagaat attacataca    900

attggaaagt ggacaagttc ctgtatatgc tgtcactttt caagaacctg agaatgatcc    960

tcggaattgc tgttacttgt gggctgttca gtctacacaa gatagtgaag gggatgtttt   1020

gagtttgcat ctgctgcagc tggcctttgg taatagaaag tgtttggcat caggacaaat   1080

cttatatgag gggttagaat actgtgaaga aagatacacc ctggacctga caggtggcat   1140

gttccctttg aggggacaga cgagtaatac caaattgttg ggatgccaga gtatagagaa   1200

atttcgatct catggtgaca gggaggaagg cgtgaatgaa gctctatcgc ctgacactag   1260

tgtttcagtc tttacctggc aggtgaatat atatggacag ggaaagcctt ctgtatattt   1320

ggggcttttt gatataaatc gttggtatca tgcacaaatg ccagattcgt taaggtcagg   1380

agaatatcta cataattgct cttattttgc actgtggtca ttggagtctg ttgtaagtag   1440

gacttctcca catggcatct tggatatatt agtacatgag agaagtttaa atagaggagt   1500

ccctccttca tatccacctc ccgagcagtt ttttaatcca agcacttata attttgatgc   1560

cacttgtttg ttaaactcgg gagttgttca tttaacttgt actggctttc agaaggagac   1620

tttgactttt ttaaagaaat caggtccatc actcaatgaa ctcattcctg atggttataa   1680

tcgatgtctt gtagctggcc ttctttcccc aagatttgtt gatgttcagc cttccagttt   1740

aagccaagaa gaacagttag aagctatatt gtcagcagca attcagacta gttccctggg   1800

acttttgact ggttatatcc gaagatggat aacagaagaa caaccaaatt ctgccactaa   1860

tttgcgcttt gttcttgaat ggacgtggaa taaagtggtt ctcacaaaag aggaatttga   1920

cagactatgt gtgccattat ttgatggttc gtgtcatttc atggatccac aaactataca   1980

gtctatccag caatgctatt tgcttcttag caatcttaat atagtcttga gctgttttgc   2040

atcagaagcc cgagagatca ctgagagagg actgatagac ttaagcaata agtttgtggt   2100

ttcccacctc atctgtcagt atgcacaagt ggttctttgg ttctctcatt ctgggctttt   2160

accagaaggc atagatgatt ctgtgcagtt gtcaaggtta tgctacaact accctgtaat   2220

tcagaactac tacaccagtc gtcgacagaa gtttgagcgt ttatcaagag ggaagtggaa   2280

tcccgattgc ttgatgattg atggactggt ttctcagtta ggagagcgaa ttgagaagtt   2340

gtggaaacga gatgaaggag gcacaggaaa atatcctcct gctagtctgc atgcagtact   2400

tgatatgtac ctattagacg gcgttactga agcagccaaa cactctatta ccatttattt   2460

gctacttgat attatgtatt cctttcccaa caaaacagac actcccattg aatctttccc   2520

aactgtattt gccatttctt ggggccaagt taaacttatt caggggtttt ggttgataga   2580

tcataatgac tatgagagtg gtttggatct tttgtttcat ccagctactg caaaaccttt   2640

gtcatggcaa cattcaaaga ttattcaggc attcatgagt cagggcgagc acagacaagc   2700

cctcagatat attcagacaa tgaagccaac agtgtccagt ggtaacgatg ttatccttca   2760

cctcactgtt ttgcttttta ataggtgtat ggttgaagcc tggaattttt tgcggcaaca   2820

ttgcaatagg ttgaatatag aggagttact gaagcacatg tatgaagtct gtcaggaaat   2880

gggcttgatg gaagatttac tgaagttacc atttacagac actgagcagg aatgtttagt   2940

gaaatttttg cagtccagtg ccagcgttca gaatcatgaa ttccttttag tgcaccattt   3000

gcagcgtgcc aattatgtgc ctgccttgaa gctgaaccaa actctgaaga ttaatgttat   3060

gaatgatcgt gatcctcgtt tgcgggagag atcactggct cgaaattcta tattagacca   3120

gtatggaaaa atccttccta gagtccatcg aaaattagcc attgaacgag ctaagcctta   3180

tcatctgtca acatcatcag tttttcgatt agtttctaga cccaaaccat tatcagcagt   3240

tccaaagcaa gttgtaacag gaactgtgtt gacaagatct gttttcatca acaatgtgtt   3300

atctaaaatt ggagaagttt gggcaagcaa agaacctata aatagcacca cacctttcaa   3360

tagttctaaa atagaagaac catctcctat agtgtattcg ctcccagctc cagagctgcc   3420

tgaggcattt tttggaacac caatttcaaa agcatcacaa aaaatttcta gactgctaga   3480

tttggttgtt cagcctgtcc cccggccttc tcagtgttcg gagtttattc agcaaagctc   3540

catgaaatct cctttgtacc tagtatcccg ttcactgccc tcaagttcgc aattaaaagg   3600

atcgcctcag gccatctcca gggcttcaga attacatttg cttgaaactc ctcttgtagt   3660

taagaaagct aaaagtttgg ccatgtcagt tactacttct ggattttctg agttcactcc   3720

tcagtccatc ctgaggtcta ctcttcgatc aacaccttta gcatctccct ctccatcacc   3780

tggaaggtct cctcaacgac ttaaagaaac tagaatttca tttgtggaag aagatgtcca   3840

cccaaaatgg attcctgggg ctgcagatga tagcaaatta gaagtattta ctacacctaa   3900

aaaatgtgca gttccagtgg aaactgaatg gctgaagagc aaagatagga ccacatcttt   3960

tttcctgaac agccctgaaa aggagcatca agaaatggat gaggggtcac aaagtttaga   4020

gaaactggat gtgagcaaag gaaacagcag tgtttcaatc acatccgatg agactacctt   4080

agagtatcag gatgcaccgt caccggaaga ccttgaagag actgttttca cggcctctaa   4140

gcccaaaagc tcttccactg cactaactac taatgtaact gaacaaactg aaaaggatgg   4200

agataaagat gtatttgcat cagaagtaac tccttcagac ctacagaaac aaatgggcaa   4260

tttagaagat gcagaaacaa aggatctctt agttgcagca gaggcatttt cagaattgaa   4320

tcacttaagc ccggttcaag gaactgaagc ttctctttgt gcaccatcag tctatgaagg   4380

gaaaatcttc acccagaagt ccaaggtacc agtgttggac gaaggattaa catctgttga   4440

aacctacacc cctgcaatta gagcaaatga caataaatct atggctgatg tccttggtga   4500

tggtggaaac tcctcgctca ctatctctga aggtcctatt gtctctgagc gcaggcttaa   4560

ccaggaagta gcgctgaact taaaagaaga tcatgaagta gaagttggtg tactaaaaga   4620

aagtgttgac ttaccagaag aaaagcttcc aatttctgac agccctcctg atactcaaga   4680

aattcatgtg attgaacaag aaaagcttga agctcaagat tcaggagaag aggctaggaa   4740

tctttcattt aatgagttat atccctctgg aacacttaag cttcagtaca attttgatac   4800

tattgaccaa cagttttgtg acttagctga taacaaagac actgctgaat gtgacattgc   4860

tgaagtagat ggggaacttt ttgtggctca aagcaacttt accttgatat tggaaggtga   4920

agaaggagaa gttgagccag gtgattttgc atcatctgat gtgttaccta aagcagctaa   4980

cacagcaact gaagaaaaac ttgtatgcag tggggaaaat gataatcatg gacaaattgc   5040

aaatttgcca tctgccgtaa ctagtgacca aaagtcccaa aaagtagaca ctttaccata   5100

tgtgcctgaa cctattaaag tagcaattgc agaaaattta ctagatgtaa ttaaagacac   5160

aagaagtaaa gaaattactt cagatacaat ggaacagtcc attcatgaaa caataccttt   5220

agtgagccaa aacataatgt gtcccactaa attggtcaaa tctgcattta agactgctca   5280

ggaaacaagc acaatgacta tgaatgtcag ccaggttgat gacgtggttt cctccaaaac   5340

tcgtacgaga ggtcaacgta tccaaaacgt gaatgtcaaa tcagcacaac aggaagcatc   5400

agcagatgtt gctactccta agatgccagg gcagtcagtc aggaagaaaa ctaggaaggc   5460

aaaagaaatt tctgaagctt ctgaaaacat ctattctgat gtcagaggac tatctcagaa   5520

ccagcaaata cctcaaaatt ctgttacgcc taggagagga aggagaaaga aagaagttaa   5580

tcaggacata ctagaaaaca ccagttctgt ggaacaagaa ttacagatca ctacaggtag   5640

ggaatcaaaa agattaaaat catctcagct gttggaacca gcagttgaag aaactactaa   5700

aaaagaagtt aaggtttcat ctgttacaaa aaggactcct agaagaatta aaagatctgt   5760

agaaaatcag gaaagtgttg aaattataaa tgatctaaaa gttagtacgg taacaagtcc   5820

tagcagaatg atcagaaaat tgagaagtac taatttagat gcttctgaaa atacaggaaa   5880

taagcaagat gataaatcca gtgacaagca gctgcgtatt aaacatgtta gaagggtcag   5940

agggagagaa gttagtccat cagatgtgag agaagactcc aaccttgagt catctcagtt   6000

gactgttcaa gcagaatttg atatgtctgc catacctaga aaacgtggta gaccaagaaa   6060

aatcaatcca tctgaagatg taggatctaa ggctgttaag gaagagagaa gccccaagaa   6120

gaaagaagct cccagcatta gaaggagatc tacaagaaat accccagcta aaagtgaaaa   6180

tgttgatgtt ggaaaaccag ctttaggaaa atccatttta gtgccaaacg aggaactttc   6240

gatggtgatg agctctaaga aaaaacttac aaaaaagact gaaagtcaaa gccaaaaacg   6300

ttcattgcac tcagtatcag aagaacgcac agatgaaatg acacataaag aaacaaatga   6360

gcaggaagaa agattgctcg ccacagcttc cttcactaaa tcatcccgca gcagcaggac   6420

tcggtctagc aaggccatct tgttgccgga cctttctgaa ccaaacaatg agcctttatt   6480

ttctccagcg tcagaagttc caaggaaagc aaaagctaaa aaaatagagg ttcctgcaca   6540

gctgaaagaa ttagtttcgg atttatcttc tcagtttgtc atctcacctc ctgctttaag   6600

gagcagacaa aaaaacacat ccaataagaa caagcttgaa gatgaactga aagatgatgc   6660

acaatcagta gaaactctgg gaaagccaaa agcgaaacga atcaggacgt caaaaacaaa   6720

acaagcaagc aaaaacacag aaaaagaaag tgcttggtca cctcctccca tagaaattcg   6780

gctgatttcc cccttggcta gcccagctga cggagtcaag agcaaaccaa gaaaaactac   6840

agaagtgaca ggaacaggtc ttggaaggaa cagaaagaaa ctgtcttcct atccaaagca   6900

aattttacgc agaaaaatgc tgtaatttct tgggaagatt ttaatgtaca cctatttgta   6960

aagtcatcag aatagtgtgg attattaaat atctagtttg gaagaaaata atttatataa   7020

attattgtaa atttttatgt aaacagaagg tcttcaataa gtaaagtaac tccatatgga   7080

gtgattgttt cagtccaggc aatttttcta ttttatatta agacttcata catttatata   7140

tgtaaatatg gcttattaat ggaatgttaa ataaaatgta tacttcacag tc           7192


<210>  2173
<211>  2275
<212>  PRT
<213>  Homo sapiens

<400>  2173

Met Ala Ala Glu Arg Arg Cys Gly Ser Met Arg Asp Leu Arg Ala Gln 
1               5                   10                  15


Val Thr Ser Gly Leu Leu Pro Phe Pro Glu Val Thr Leu Gln Ala Leu 
            20                  25                  30


Gly Glu Asp Glu Ile Thr Leu Glu Ser Val Leu Arg Gly Lys Phe Ala 
        35                  40                  45


Ala Gly Lys Asn Gly Leu Ala Cys Leu Ala Cys Gly Pro Gln Leu Glu 
    50                  55                  60


Val Val Asn Ser Ile Thr Gly Glu Arg Leu Ser Ala Tyr Arg Phe Ser 
65                  70                  75                  80


Gly Val Asn Glu Gln Pro Pro Val Val Leu Ala Val Lys Glu Phe Ser 
                85                  90                  95


Trp Gln Lys Arg Thr Gly Leu Leu Ile Gly Leu Glu Glu Thr Glu Gly 
            100                 105                 110


Ser Val Leu Cys Leu Tyr Asp Leu Gly Ile Ser Lys Val Val Lys Ala 
        115                 120                 125


Val Val Leu Pro Gly Arg Val Thr Ala Ile Glu Pro Ile Ile Asn His 
    130                 135                 140


Gly Gly Ala Ser Ala Ser Thr Gln His Leu His Pro Ser Leu Arg Trp 
145                 150                 155                 160


Leu Phe Gly Val Ala Ala Val Val Thr Asp Val Gly Gln Ile Leu Leu 
                165                 170                 175


Val Asp Leu Cys Leu Asp Asp Leu Ser Cys Asn Gln Asn Glu Val Glu 
            180                 185                 190


Ala Ser Asp Leu Glu Val Leu Thr Gly Ile Pro Ala Glu Val Pro His 
        195                 200                 205


Ile Arg Glu Ser Val Met Arg Gln Gly Arg His Leu Cys Phe Gln Leu 
    210                 215                 220


Val Ser Pro Thr Gly Thr Ala Val Ser Thr Leu Ser Tyr Ile Ser Arg 
225                 230                 235                 240


Thr Asn Gln Leu Ala Val Gly Phe Ser Asp Gly Tyr Leu Ala Leu Trp 
                245                 250                 255


Asn Met Lys Ser Met Lys Arg Glu Tyr Tyr Ile Gln Leu Glu Ser Gly 
            260                 265                 270


Gln Val Pro Val Tyr Ala Val Thr Phe Gln Glu Pro Glu Asn Asp Pro 
        275                 280                 285


Arg Asn Cys Cys Tyr Leu Trp Ala Val Gln Ser Thr Gln Asp Ser Glu 
    290                 295                 300


Gly Asp Val Leu Ser Leu His Leu Leu Gln Leu Ala Phe Gly Asn Arg 
305                 310                 315                 320


Lys Cys Leu Ala Ser Gly Gln Ile Leu Tyr Glu Gly Leu Glu Tyr Cys 
                325                 330                 335


Glu Glu Arg Tyr Thr Leu Asp Leu Thr Gly Gly Met Phe Pro Leu Arg 
            340                 345                 350


Gly Gln Thr Ser Asn Thr Lys Leu Leu Gly Cys Gln Ser Ile Glu Lys 
        355                 360                 365


Phe Arg Ser His Gly Asp Arg Glu Glu Gly Val Asn Glu Ala Leu Ser 
    370                 375                 380


Pro Asp Thr Ser Val Ser Val Phe Thr Trp Gln Val Asn Ile Tyr Gly 
385                 390                 395                 400


Gln Gly Lys Pro Ser Val Tyr Leu Gly Leu Phe Asp Ile Asn Arg Trp 
                405                 410                 415


Tyr His Ala Gln Met Pro Asp Ser Leu Arg Ser Gly Glu Tyr Leu His 
            420                 425                 430


Asn Cys Ser Tyr Phe Ala Leu Trp Ser Leu Glu Ser Val Val Ser Arg 
        435                 440                 445


Thr Ser Pro His Gly Ile Leu Asp Ile Leu Val His Glu Arg Ser Leu 
    450                 455                 460


Asn Arg Gly Val Pro Pro Ser Tyr Pro Pro Pro Glu Gln Phe Phe Asn 
465                 470                 475                 480


Pro Ser Thr Tyr Asn Phe Asp Ala Thr Cys Leu Leu Asn Ser Gly Val 
                485                 490                 495


Val His Leu Thr Cys Thr Gly Phe Gln Lys Glu Thr Leu Thr Phe Leu 
            500                 505                 510


Lys Lys Ser Gly Pro Ser Leu Asn Glu Leu Ile Pro Asp Gly Tyr Asn 
        515                 520                 525


Arg Cys Leu Val Ala Gly Leu Leu Ser Pro Arg Phe Val Asp Val Gln 
    530                 535                 540


Pro Ser Ser Leu Ser Gln Glu Glu Gln Leu Glu Ala Ile Leu Ser Ala 
545                 550                 555                 560


Ala Ile Gln Thr Ser Ser Leu Gly Leu Leu Thr Gly Tyr Ile Arg Arg 
                565                 570                 575


Trp Ile Thr Glu Glu Gln Pro Asn Ser Ala Thr Asn Leu Arg Phe Val 
            580                 585                 590


Leu Glu Trp Thr Trp Asn Lys Val Val Leu Thr Lys Glu Glu Phe Asp 
        595                 600                 605


Arg Leu Cys Val Pro Leu Phe Asp Gly Ser Cys His Phe Met Asp Pro 
    610                 615                 620


Gln Thr Ile Gln Ser Ile Gln Gln Cys Tyr Leu Leu Leu Ser Asn Leu 
625                 630                 635                 640


Asn Ile Val Leu Ser Cys Phe Ala Ser Glu Ala Arg Glu Ile Thr Glu 
                645                 650                 655


Arg Gly Leu Ile Asp Leu Ser Asn Lys Phe Val Val Ser His Leu Ile 
            660                 665                 670


Cys Gln Tyr Ala Gln Val Val Leu Trp Phe Ser His Ser Gly Leu Leu 
        675                 680                 685


Pro Glu Gly Ile Asp Asp Ser Val Gln Leu Ser Arg Leu Cys Tyr Asn 
    690                 695                 700


Tyr Pro Val Ile Gln Asn Tyr Tyr Thr Ser Arg Arg Gln Lys Phe Glu 
705                 710                 715                 720


Arg Leu Ser Arg Gly Lys Trp Asn Pro Asp Cys Leu Met Ile Asp Gly 
                725                 730                 735


Leu Val Ser Gln Leu Gly Glu Arg Ile Glu Lys Leu Trp Lys Arg Asp 
            740                 745                 750


Glu Gly Gly Thr Gly Lys Tyr Pro Pro Ala Ser Leu His Ala Val Leu 
        755                 760                 765


Asp Met Tyr Leu Leu Asp Gly Val Thr Glu Ala Ala Lys His Ser Ile 
    770                 775                 780


Thr Ile Tyr Leu Leu Leu Asp Ile Met Tyr Ser Phe Pro Asn Lys Thr 
785                 790                 795                 800


Asp Thr Pro Ile Glu Ser Phe Pro Thr Val Phe Ala Ile Ser Trp Gly 
                805                 810                 815


Gln Val Lys Leu Ile Gln Gly Phe Trp Leu Ile Asp His Asn Asp Tyr 
            820                 825                 830


Glu Ser Gly Leu Asp Leu Leu Phe His Pro Ala Thr Ala Lys Pro Leu 
        835                 840                 845


Ser Trp Gln His Ser Lys Ile Ile Gln Ala Phe Met Ser Gln Gly Glu 
    850                 855                 860


His Arg Gln Ala Leu Arg Tyr Ile Gln Thr Met Lys Pro Thr Val Ser 
865                 870                 875                 880


Ser Gly Asn Asp Val Ile Leu His Leu Thr Val Leu Leu Phe Asn Arg 
                885                 890                 895


Cys Met Val Glu Ala Trp Asn Phe Leu Arg Gln His Cys Asn Arg Leu 
            900                 905                 910


Asn Ile Glu Glu Leu Leu Lys His Met Tyr Glu Val Cys Gln Glu Met 
        915                 920                 925


Gly Leu Met Glu Asp Leu Leu Lys Leu Pro Phe Thr Asp Thr Glu Gln 
    930                 935                 940


Glu Cys Leu Val Lys Phe Leu Gln Ser Ser Ala Ser Val Gln Asn His 
945                 950                 955                 960


Glu Phe Leu Leu Val His His Leu Gln Arg Ala Asn Tyr Val Pro Ala 
                965                 970                 975


Leu Lys Leu Asn Gln Thr Leu Lys Ile Asn Val Met Asn Asp Arg Asp 
            980                 985                 990


Pro Arg Leu Arg Glu Arg Ser Leu Ala Arg Asn Ser Ile Leu Asp Gln 
        995                 1000                1005


Tyr Gly Lys Ile Leu Pro Arg Val His Arg Lys Leu Ala Ile Glu Arg 
    1010                1015                1020


Ala Lys Pro Tyr His Leu Ser Thr Ser Ser Val Phe Arg Leu Val Ser 
1025                1030                1035                1040


Arg Pro Lys Pro Leu Ser Ala Val Pro Lys Gln Val Val Thr Gly Thr 
                1045                1050                1055


Val Leu Thr Arg Ser Val Phe Ile Asn Asn Val Leu Ser Lys Ile Gly 
            1060                1065                1070


Glu Val Trp Ala Ser Lys Glu Pro Ile Asn Ser Thr Thr Pro Phe Asn 
        1075                1080                1085


Ser Ser Lys Ile Glu Glu Pro Ser Pro Ile Val Tyr Ser Leu Pro Ala 
    1090                1095                1100


Pro Glu Leu Pro Glu Ala Phe Phe Gly Thr Pro Ile Ser Lys Ala Ser 
1105                1110                1115                1120


Gln Lys Ile Ser Arg Leu Leu Asp Leu Val Val Gln Pro Val Pro Arg 
                1125                1130                1135


Pro Ser Gln Cys Ser Glu Phe Ile Gln Gln Ser Ser Met Lys Ser Pro 
            1140                1145                1150


Leu Tyr Leu Val Ser Arg Ser Leu Pro Ser Ser Ser Gln Leu Lys Gly 
        1155                1160                1165


Ser Pro Gln Ala Ile Ser Arg Ala Ser Glu Leu His Leu Leu Glu Thr 
    1170                1175                1180


Pro Leu Val Val Lys Lys Ala Lys Ser Leu Ala Met Ser Val Thr Thr 
1185                1190                1195                1200


Ser Gly Phe Ser Glu Phe Thr Pro Gln Ser Ile Leu Arg Ser Thr Leu 
                1205                1210                1215


Arg Ser Thr Pro Leu Ala Ser Pro Ser Pro Ser Pro Gly Arg Ser Pro 
            1220                1225                1230


Gln Arg Leu Lys Glu Thr Arg Ile Ser Phe Val Glu Glu Asp Val His 
        1235                1240                1245


Pro Lys Trp Ile Pro Gly Ala Ala Asp Asp Ser Lys Leu Glu Val Phe 
    1250                1255                1260


Thr Thr Pro Lys Lys Cys Ala Val Pro Val Glu Thr Glu Trp Leu Lys 
1265                1270                1275                1280


Ser Lys Asp Arg Thr Thr Ser Phe Phe Leu Asn Ser Pro Glu Lys Glu 
                1285                1290                1295


His Gln Glu Met Asp Glu Gly Ser Gln Ser Leu Glu Lys Leu Asp Val 
            1300                1305                1310


Ser Lys Gly Asn Ser Ser Val Ser Ile Thr Ser Asp Glu Thr Thr Leu 
        1315                1320                1325


Glu Tyr Gln Asp Ala Pro Ser Pro Glu Asp Leu Glu Glu Thr Val Phe 
    1330                1335                1340


Thr Ala Ser Lys Pro Lys Ser Ser Ser Thr Ala Leu Thr Thr Asn Val 
1345                1350                1355                1360


Thr Glu Gln Thr Glu Lys Asp Gly Asp Lys Asp Val Phe Ala Ser Glu 
                1365                1370                1375


Val Thr Pro Ser Asp Leu Gln Lys Gln Met Gly Asn Leu Glu Asp Ala 
            1380                1385                1390


Glu Thr Lys Asp Leu Leu Val Ala Ala Glu Ala Phe Ser Glu Leu Asn 
        1395                1400                1405


His Leu Ser Pro Val Gln Gly Thr Glu Ala Ser Leu Cys Ala Pro Ser 
    1410                1415                1420


Val Tyr Glu Gly Lys Ile Phe Thr Gln Lys Ser Lys Val Pro Val Leu 
1425                1430                1435                1440


Asp Glu Gly Leu Thr Ser Val Glu Thr Tyr Thr Pro Ala Ile Arg Ala 
                1445                1450                1455


Asn Asp Asn Lys Ser Met Ala Asp Val Leu Gly Asp Gly Gly Asn Ser 
            1460                1465                1470


Ser Leu Thr Ile Ser Glu Gly Pro Ile Val Ser Glu Arg Arg Leu Asn 
        1475                1480                1485


Gln Glu Val Ala Leu Asn Leu Lys Glu Asp His Glu Val Glu Val Gly 
    1490                1495                1500


Val Leu Lys Glu Ser Val Asp Leu Pro Glu Glu Lys Leu Pro Ile Ser 
1505                1510                1515                1520


Asp Ser Pro Pro Asp Thr Gln Glu Ile His Val Ile Glu Gln Glu Lys 
                1525                1530                1535


Leu Glu Ala Gln Asp Ser Gly Glu Glu Ala Arg Asn Leu Ser Phe Asn 
            1540                1545                1550


Glu Leu Tyr Pro Ser Gly Thr Leu Lys Leu Gln Tyr Asn Phe Asp Thr 
        1555                1560                1565


Ile Asp Gln Gln Phe Cys Asp Leu Ala Asp Asn Lys Asp Thr Ala Glu 
    1570                1575                1580


Cys Asp Ile Ala Glu Val Asp Gly Glu Leu Phe Val Ala Gln Ser Asn 
1585                1590                1595                1600


Phe Thr Leu Ile Leu Glu Gly Glu Glu Gly Glu Val Glu Pro Gly Asp 
                1605                1610                1615


Phe Ala Ser Ser Asp Val Leu Pro Lys Ala Ala Asn Thr Ala Thr Glu 
            1620                1625                1630


Glu Lys Leu Val Cys Ser Gly Glu Asn Asp Asn His Gly Gln Ile Ala 
        1635                1640                1645


Asn Leu Pro Ser Ala Val Thr Ser Asp Gln Lys Ser Gln Lys Val Asp 
    1650                1655                1660


Thr Leu Pro Tyr Val Pro Glu Pro Ile Lys Val Ala Ile Ala Glu Asn 
1665                1670                1675                1680


Leu Leu Asp Val Ile Lys Asp Thr Arg Ser Lys Glu Ile Thr Ser Asp 
                1685                1690                1695


Thr Met Glu Gln Ser Ile His Glu Thr Ile Pro Leu Val Ser Gln Asn 
            1700                1705                1710


Ile Met Cys Pro Thr Lys Leu Val Lys Ser Ala Phe Lys Thr Ala Gln 
        1715                1720                1725


Glu Thr Ser Thr Met Thr Met Asn Val Ser Gln Val Asp Asp Val Val 
    1730                1735                1740


Ser Ser Lys Thr Arg Thr Arg Gly Gln Arg Ile Gln Asn Val Asn Val 
1745                1750                1755                1760


Lys Ser Ala Gln Gln Glu Ala Ser Ala Asp Val Ala Thr Pro Lys Met 
                1765                1770                1775


Pro Gly Gln Ser Val Arg Lys Lys Thr Arg Lys Ala Lys Glu Ile Ser 
            1780                1785                1790


Glu Ala Ser Glu Asn Ile Tyr Ser Asp Val Arg Gly Leu Ser Gln Asn 
        1795                1800                1805


Gln Gln Ile Pro Gln Asn Ser Val Thr Pro Arg Arg Gly Arg Arg Lys 
    1810                1815                1820


Lys Glu Val Asn Gln Asp Ile Leu Glu Asn Thr Ser Ser Val Glu Gln 
1825                1830                1835                1840


Glu Leu Gln Ile Thr Thr Gly Arg Glu Ser Lys Arg Leu Lys Ser Ser 
                1845                1850                1855


Gln Leu Leu Glu Pro Ala Val Glu Glu Thr Thr Lys Lys Glu Val Lys 
            1860                1865                1870


Val Ser Ser Val Thr Lys Arg Thr Pro Arg Arg Ile Lys Arg Ser Val 
        1875                1880                1885


Glu Asn Gln Glu Ser Val Glu Ile Ile Asn Asp Leu Lys Val Ser Thr 
    1890                1895                1900


Val Thr Ser Pro Ser Arg Met Ile Arg Lys Leu Arg Ser Thr Asn Leu 
1905                1910                1915                1920


Asp Ala Ser Glu Asn Thr Gly Asn Lys Gln Asp Asp Lys Ser Ser Asp 
                1925                1930                1935


Lys Gln Leu Arg Ile Lys His Val Arg Arg Val Arg Gly Arg Glu Val 
            1940                1945                1950


Ser Pro Ser Asp Val Arg Glu Asp Ser Asn Leu Glu Ser Ser Gln Leu 
        1955                1960                1965


Thr Val Gln Ala Glu Phe Asp Met Ser Ala Ile Pro Arg Lys Arg Gly 
    1970                1975                1980


Arg Pro Arg Lys Ile Asn Pro Ser Glu Asp Val Gly Ser Lys Ala Val 
1985                1990                1995                2000


Lys Glu Glu Arg Ser Pro Lys Lys Lys Glu Ala Pro Ser Ile Arg Arg 
                2005                2010                2015


Arg Ser Thr Arg Asn Thr Pro Ala Lys Ser Glu Asn Val Asp Val Gly 
            2020                2025                2030


Lys Pro Ala Leu Gly Lys Ser Ile Leu Val Pro Asn Glu Glu Leu Ser 
        2035                2040                2045


Met Val Met Ser Ser Lys Lys Lys Leu Thr Lys Lys Thr Glu Ser Gln 
    2050                2055                2060


Ser Gln Lys Arg Ser Leu His Ser Val Ser Glu Glu Arg Thr Asp Glu 
2065                2070                2075                2080


Met Thr His Lys Glu Thr Asn Glu Gln Glu Glu Arg Leu Leu Ala Thr 
                2085                2090                2095


Ala Ser Phe Thr Lys Ser Ser Arg Ser Ser Arg Thr Arg Ser Ser Lys 
            2100                2105                2110


Ala Ile Leu Leu Pro Asp Leu Ser Glu Pro Asn Asn Glu Pro Leu Phe 
        2115                2120                2125


Ser Pro Ala Ser Glu Val Pro Arg Lys Ala Lys Ala Lys Lys Ile Glu 
    2130                2135                2140


Val Pro Ala Gln Leu Lys Glu Leu Val Ser Asp Leu Ser Ser Gln Phe 
2145                2150                2155                2160


Val Ile Ser Pro Pro Ala Leu Arg Ser Arg Gln Lys Asn Thr Ser Asn 
                2165                2170                2175


Lys Asn Lys Leu Glu Asp Glu Leu Lys Asp Asp Ala Gln Ser Val Glu 
            2180                2185                2190


Thr Leu Gly Lys Pro Lys Ala Lys Arg Ile Arg Thr Ser Lys Thr Lys 
        2195                2200                2205


Gln Ala Ser Lys Asn Thr Glu Lys Glu Ser Ala Trp Ser Pro Pro Pro 
    2210                2215                2220


Ile Glu Ile Arg Leu Ile Ser Pro Leu Ala Ser Pro Ala Asp Gly Val 
2225                2230                2235                2240


Lys Ser Lys Pro Arg Lys Thr Thr Glu Val Thr Gly Thr Gly Leu Gly 
                2245                2250                2255


Arg Asn Arg Lys Lys Leu Ser Ser Tyr Pro Lys Gln Ile Leu Arg Arg 
            2260                2265                2270


Lys Met Leu 
        2275


<210>  2174
<211>  1028
<212>  DNA
<213>  Homo sapiens

<400>  2174
cgtctgctgc ctctcggaga gtcccgggtg actgccgcag gctccatcgc cctgtggcct     60

gcaggtattg cgagatttat agggaggacg ctgggacccc caaaagctgg gaaatgggac    120

tattggcatt cagggatgtg gctctagaat tctctccaga ggagtgggaa tgcctggacc    180

cagctcagcg gagtttgtat agggatgtga tgttagagaa ctacagaaac ctgatctccc    240

ttggtgagga tagcttcaat atgcaattcc tatttcacag tcttgctatg tctaagccag    300

aactgatcat ctgtctggag gcaaggaaag agccctggaa cgtgaacaca gagaagacag    360

ccagacactc agttttgtct tcttatctta ctgaagacat tttgccagag cagggcctgc    420

aagtttcatt ccaaaaagtg atgctgagaa gatatgaaag atgttgtctt gagaaattac    480

gcttaaggaa tgactgggaa attgtgggtg aggtccagtc gtcgaccatc gagctgcttt    540

gaagaccctg cggaggttcc gtcgctgctt gaacacagtg cctggactcc ctgctccgtg    600

aggcgaattt acaccgggtc cagctgcgtc agcccgagtt ctgaattaaa acatgcctcc    660

cacagaatct atttctgatg aatatgaaag gaagattgtt cttccatgtt ggtttttatt    720

gagatatctc tttttttccc ttttcatttg gttgtcctaa ctccatgaat agaaaagaaa    780

atgtattaat tcatttttta attttctttt ttattatttt gttagtgttt cacttttttt    840

ctgcactaca cagatgtagt gtattcattc atttttttaa aaaaaaaggc tgggtgcagt    900

ggctcacacc tgtgatccca gcactttggg aggctgaggc aggtgaatca cgaggtcaga    960

agttcgagac cagcctggcc aagatggtga aagcccgttt ctactaaaaa taaaaaaaaa   1020

aaaattag                                                            1028


<210>  2175
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  2175

Met Gly Leu Leu Ala Phe Arg Asp Val Ala Leu Glu Phe Ser Pro Glu 
1               5                   10                  15


Glu Trp Glu Cys Leu Asp Pro Ala Gln Arg Ser Leu Tyr Arg Asp Val 
            20                  25                  30


Met Leu Glu Asn Tyr Arg Asn Leu Ile Ser Leu Gly Glu Asp Ser Phe 
        35                  40                  45


Asn Met Gln Phe Leu Phe His Ser Leu Ala Met Ser Lys Pro Glu Leu 
    50                  55                  60


Ile Ile Cys Leu Glu Ala Arg Lys Glu Pro Trp Asn Val Asn Thr Glu 
65                  70                  75                  80


Lys Thr Ala Arg His Ser Val Leu Ser Ser Tyr Leu Thr Glu Asp Ile 
                85                  90                  95


Leu Pro Glu Gln Gly Leu Gln Val Ser Phe Gln Lys Val Met Leu Arg 
            100                 105                 110


Arg Tyr Glu Arg Cys Cys Leu Glu Lys Leu Arg Leu Arg Asn Asp Trp 
        115                 120                 125


Glu Ile Val Gly Glu Val Gln Ser Ser Thr Ile Glu Leu Leu 
    130                 135                 140


<210>  2176
<211>  1019
<212>  DNA
<213>  Homo sapiens

<400>  2176
gtctccttgc ggccggcggg gtgctgggtt cccgtctgct gcctctcgga gagtcccggg     60

tgactgccgc aggctccatc gccctgtggc ctgcaggtat tgcgagattt atagggagga    120

cgctgggacc cccaaaagct gggaaatggg actattggca ttcagggatg tggctctaga    180

attctctcca gaggagtggg aatgcctgga cccagctcag cggagtttgt atagggatgt    240

gatgttagag aactacagaa acctgatctc ccttggtgag gatagcttca atatgcaatt    300

cctatttcac agtcttgcta tgtctaagcc agaactgatc atctgtctgg aggcaaggaa    360

agagccctgg aacgtgaaca cagagaagac agccagacac tcagccatgt gaagatgtgc    420

ttgcttcccc tttgccttct gccatgattc taagtttcct gaggcctccc cagaagcaga    480

agcatgtaaa gcccacagaa ccggtccagt cgtcgaccat cgagctgctt tgaagaccct    540

gcggaggttc cgtcgctgct tgaacacagt gcctggactc cctgctccgt gaggcgaatt    600

tacaccgggt ccagctgcgt cagcccgagt tctgaattaa aacatgcctc ccacagaatc    660

tatttctgat gaatatgaaa ggaagattgt tcttccatgt tggtttttat tgagatatct    720

ctttttttcc cttttcattt ggttgtccta actccatgaa tagaaaagaa aatgtattaa    780

ttcatttttt aattttcttt tttattattt tgttagtgtt tcactttttt tctgcactac    840

acagatgtag tgtattcatt cattttttta aaaaaaaagg ctgggtgcag tggctcacac    900

ctgtgatccc agcactttgg gaggctgagg caggtgaatc acgaggtcag aagttcgaga    960

ccagcctggc caagatggtg aaagcccgtt tctactaaaa ataaaaaaaa aaaaattag    1019


<210>  2177
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  2177

Met Gly Leu Leu Ala Phe Arg Asp Val Ala Leu Glu Phe Ser Pro Glu 
1               5                   10                  15


Glu Trp Glu Cys Leu Asp Pro Ala Gln Arg Ser Leu Tyr Arg Asp Val 
            20                  25                  30


Met Leu Glu Asn Tyr Arg Asn Leu Ile Ser Leu Gly Glu Asp Ser Phe 
        35                  40                  45


Asn Met Gln Phe Leu Phe His Ser Leu Ala Met Ser Lys Pro Glu Leu 
    50                  55                  60


Ile Ile Cys Leu Glu Ala Arg Lys Glu Pro Trp Asn Val Asn Thr Glu 
65                  70                  75                  80


Lys Thr Ala Arg His Ser Ala Met 
                85


<210>  2178
<211>  1278
<212>  DNA
<213>  Homo sapiens

<400>  2178
tggcgagctc ggtgcgtctc cgctgctcct tccccttatc cctgggaggt ccaagtggtc     60

ccgcggcagc ttctgttgct ctgggacctg caggtcccgg aaggtcctta gggaggaccc    120

cagacaccgg agactgggaa atgggactat tggcattcag ggatgtggct ctagaattct    180

ctccagagga gtgggaatgc ctggacccag ctcagcggag tttgtatagg gatgtgatgt    240

tagagaacta cagaaacctg atctcccttg gtcttgctat gtctaagcca gaactgatca    300

tctgtctgga ggcaaggaaa gagccctgga acgtgaacac agagaagaca gccagacact    360

cagttttgtc ttcttatctt actgaagaca ttttgccaga gcagggcctg caagtttcat    420

tccaaaaagt gatgctgaga agatatgaaa gatgttgtct tgagaaatta cgcttaagga    480

atgactggga aattgtggta gagacggggt ttcaccgtgt tagccaggat ggtctcaatc    540

tcctgacctc gtgatccgcc tgtctcggcc tcccaaagtg ctgggattac agacgtgagc    600

cactgcaccc ggccagcata agatttttat atgagtaatt gggaaggctt ctataaatat    660

aagccatgtg aagatgtgct tgcttcccct ttgccttctg ccatgattct aagtttcctg    720

aggcctcccc agaagcagaa gcatgtaaag cccacagaac cggtccagtc gtcgaccatc    780

gagctgcttt gaagaccctg cggaggttcc gtcgctgctt gaacacagtg cctggactcc    840

ctgctccgtg aggcgaattt acaccgggtc cagctgcgtc agcccgagtt ctgaattaaa    900

acatgcctcc cacagaatct atttctgatg aatatgaaag gaagattgtt cttccatgtt    960

ggtttttatt gagatatctc tttttttccc ttttcatttg gttgtcctaa ctccatgaat   1020

agaaaagaaa atgtattaat tcatttttta attttctttt ttattatttt gttagtgttt   1080

cacttttttt ctgcactaca cagatgtagt gtattcattc atttttttaa aaaaaaaggc   1140

tgggtgcagt ggctcacacc tgtgatccca gcactttggg aggctgaggc aggtgaatca   1200

cgaggtcaga agttcgagac cagcctggcc aagatggtga aagcccgttt ctactaaaaa   1260

taaaaaaaaa aaaattag                                                 1278


<210>  2179
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  2179

Met Gly Leu Leu Ala Phe Arg Asp Val Ala Leu Glu Phe Ser Pro Glu 
1               5                   10                  15


Glu Trp Glu Cys Leu Asp Pro Ala Gln Arg Ser Leu Tyr Arg Asp Val 
            20                  25                  30


Met Leu Glu Asn Tyr Arg Asn Leu Ile Ser Leu Gly Leu Ala Met Ser 
        35                  40                  45


Lys Pro Glu Leu Ile Ile Cys Leu Glu Ala Arg Lys Glu Pro Trp Asn 
    50                  55                  60


Val Asn Thr Glu Lys Thr Ala Arg His Ser Val Leu Ser Ser Tyr Leu 
65                  70                  75                  80


Thr Glu Asp Ile Leu Pro Glu Gln Gly Leu Gln Val Ser Phe Gln Lys 
                85                  90                  95


Val Met Leu Arg Arg Tyr Glu Arg Cys Cys Leu Glu Lys Leu Arg Leu 
            100                 105                 110


Arg Asn Asp Trp Glu Ile Val Val Glu Thr Gly Phe His Arg Val Ser 
        115                 120                 125


Gln Asp Gly Leu Asn Leu Leu Thr Ser 
    130                 135


<210>  2180
<211>  787
<212>  DNA
<213>  Homo sapiens

<400>  2180
cgtctgctgc ctctcggaga gtcccgggtg actgccgcag gctccatcgc cctgtggcct     60

gcaggtattg cgagatttat agggaggacg ctgggacccc caaaagctgg gaaatgggac    120

tattggcatt cagggatgtg gctctagaat tctctccaga ggagtgggaa tgcctggacc    180

cagctcagcg gagtttgtat agggatgtga tgttagagaa ctacagaaac ctgatctccc    240

ttggtgagga tagcttcaat atgcaattcc tatttcacag tcttgctatg tctaagccag    300

aactgatcat ctgtctggag gcaaggaaag agccctggaa cgtgaacaca gagaagacag    360

ccagacactc agttttgtct tcttatctta ctgaagacat tttgccagag cagggcctgc    420

aagtttcatt ccaaaaagtg atgctgagaa gatatgaaag atgttgtctt gagaaattac    480

gcttaaggaa tgactgggaa attgtgggtg aggtccagtc gtcgaccatc gagctgcttt    540

gaagaccctg cggaggttcc gtcgctgctt gaacacagtg cctggactcc ctgctccgtg    600

aggcgaattt acaccgggtc cagctgcgtc agcccgagtt ctgaattaaa acatgcctcc    660

cacagaatct atttctgatg aatatgaaag gaagattgtt cttccatgtt ggtttttatt    720

gagatatctc tttttttccc ttttcatttg gttgtcctaa ctccatgaat agaaaagaaa    780

atgtatt                                                              787


<210>  2181
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  2181

Met Gly Leu Leu Ala Phe Arg Asp Val Ala Leu Glu Phe Ser Pro Glu 
1               5                   10                  15


Glu Trp Glu Cys Leu Asp Pro Ala Gln Arg Ser Leu Tyr Arg Asp Val 
            20                  25                  30


Met Leu Glu Asn Tyr Arg Asn Leu Ile Ser Leu Gly Glu Asp Ser Phe 
        35                  40                  45


Asn Met Gln Phe Leu Phe His Ser Leu Ala Met Ser Lys Pro Glu Leu 
    50                  55                  60


Ile Ile Cys Leu Glu Ala Arg Lys Glu Pro Trp Asn Val Asn Thr Glu 
65                  70                  75                  80


Lys Thr Ala Arg His Ser Val Leu Ser Ser Tyr Leu Thr Glu Asp Ile 
                85                  90                  95


Leu Pro Glu Gln Gly Leu Gln Val Ser Phe Gln Lys Val Met Leu Arg 
            100                 105                 110


Arg Tyr Glu Arg Cys Cys Leu Glu Lys Leu Arg Leu Arg Asn Asp Trp 
        115                 120                 125


Glu Ile Val Gly Glu Val Gln Ser Ser Thr Ile Glu Leu Leu 
    130                 135                 140


<210>  2182
<211>  672
<212>  DNA
<213>  Homo sapiens

<400>  2182
ctgggttccc gtctgctgcc tctcggagag tcccgggtga ctgccgcagg ctccatcgcc     60

ctgtggcctg caggtattgc gagatttata gggaggacgc tgggaccccc aaaagctggg    120

aaatgggact attggcattc agggatgtgg ctctagaatt ctctccagag gagtgggaat    180

gcctggaccc agctcagcgg agtttgtata gggatgtgat gttagagaac tacagaaacc    240

tgatctccct tggtgaggat agcttcaata tgcaattcct atttcacagt cttgctatgt    300

ctaagccaga actgatcatc tgtctggagg caaggaaaga gccctggaac gtgaacacag    360

agaagacagc cagacactca gttttgtctt cttatcttac tgaagacatt ttgccagagc    420

agggcctgca agtttcattc caaaaagtga tgctgagaag atatgaaaga tgttgtcttg    480

agaaattacg cttaaggaat gactgggaaa ttgtgggtga ggtccagtcg tcgaccatcg    540

agctgctttg aagaccctgc ggaggttccg tcgctgcttg aacacagtgc ctggactccc    600

tgctccgtga ggcgaattta caccgggtcc agctgcgtca gcccgagttc tgaattaaaa    660

catgcctccc ac                                                        672


<210>  2183
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  2183

Met Gly Leu Leu Ala Phe Arg Asp Val Ala Leu Glu Phe Ser Pro Glu 
1               5                   10                  15


Glu Trp Glu Cys Leu Asp Pro Ala Gln Arg Ser Leu Tyr Arg Asp Val 
            20                  25                  30


Met Leu Glu Asn Tyr Arg Asn Leu Ile Ser Leu Gly Glu Asp Ser Phe 
        35                  40                  45


Asn Met Gln Phe Leu Phe His Ser Leu Ala Met Ser Lys Pro Glu Leu 
    50                  55                  60


Ile Ile Cys Leu Glu Ala Arg Lys Glu Pro Trp Asn Val Asn Thr Glu 
65                  70                  75                  80


Lys Thr Ala Arg His Ser Val Leu Ser Ser Tyr Leu Thr Glu Asp Ile 
                85                  90                  95


Leu Pro Glu Gln Gly Leu Gln Val Ser Phe Gln Lys Val Met Leu Arg 
            100                 105                 110


Arg Tyr Glu Arg Cys Cys Leu Glu Lys Leu Arg Leu Arg Asn Asp Trp 
        115                 120                 125


Glu Ile Val Gly Glu Val Gln Ser Ser Thr Ile Glu Leu Leu 
    130                 135                 140


<210>  2184
<211>  504
<212>  DNA
<213>  Homo sapiens

<400>  2184
gttcccgtct gctgcctctc ggagagtccc gggtgactgc cgcaggctcc atcgccctgt     60

ggcctgcagg tattgcgaga tttataggga ggacgctggg acccccaaaa gctgggaaat    120

gttttgtctt cttatcttac tgaagacatt ttgccagagc agggcctgca agtttcattc    180

caaaaagtga tgctgagaag atatgaaaga tgttgtcttg agaaattacg cttaaggaat    240

gactgggaaa ttgtggccat gtgaagatgt gcttgcttcc cctttgcctt ctgccatgat    300

tctaagtttc ctgaggcctc cccagaagca gaagcatgta aagcccacag aaccggtcca    360

gtcgtcgacc atcgagctgc tttgaagacc ctgcggaggt tccgtcgctg cttgaacaca    420

gtgcctggac tccctgctcc gtgaggcgaa tttacaccgg gtccagctgc gtcagcccga    480

gttctgaatt aaaacatgcc tccc                                           504


<210>  2185
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  2185

Met Thr Gly Lys Leu Trp Pro Cys Glu Asp Val Leu Ala Ser Pro Leu 
1               5                   10                  15


Pro Ser Ala Met Ile Leu Ser Phe Leu Arg Pro Pro Gln Lys Gln Lys 
            20                  25                  30


His Val Lys Pro Thr Glu Pro Val Gln Ser Ser Thr Ile Glu Leu Leu 
        35                  40                  45


<210>  2186
<211>  2751
<212>  DNA
<213>  Homo sapiens

<400>  2186
actctcaagc gcgccgcgaa aggagggagc agcttccggg acctggcgcg gcttttgtgt     60

tgggcagcgc gaatgtggcg agctcggtgc gtctccgctg ctccttcccc ttatccctgg    120

gaggtccaag tggtcccgcg gcagcttctg ttgctctggg acctgcaggt cccggaaggt    180

ccttagggag gaccccagac accggagact gggaaatggg actattggca ttcagggatg    240

tggctctaga attctctcca gaggagtggg aatgcctgga cccagctcag cggagtttgt    300

atagggatgt gatgttagag aactacagaa acctgatctc ccttggtctt gctatgtcta    360

agccagaact gatcatctgt ctggaggcaa ggaaagagcc ctggaacgtg aacacagaga    420

agacagccag acactcagta gagacgaggt ttcgccatgt tggccaggct ggtctcaaac    480

tccttacctc aggtgatcca cctgccttgg cctcccaaag tgctgggatt acaggcacgg    540

gccaccactg ccagcctatt tgtgtattct gaattatatt taaccattca tttggtgagt    600

tttgtcttct tatcttactg aagacatttt gccagagcag ggcctgcaag tttcattcca    660

aaaagtgatg ctgagaagat atgaaagatg ttgtcttgag aaattacgct taaggaatga    720

ctgggaaatt gtggattatc cagactcagg tagttcttta taacaatgtg agaatgaact    780

aatacagaaa agtggtacca gagagttggg acattgctat aaagatacct gaaaatgtgg    840

aagtgacttt ggaactgggt aacaggcaga agttggaaga gtttggaggg ctcagaagaa    900

gacaggaaga taaggaaaag tttggaactt cctagagact tgttgaatgg ttgtaaccaa    960

aatgctgatg gtgatatgga caatgaagtc caggctgagg agttctcaga tggagatgag   1020

gaccttattg ggagctacag taaaggtcac tcttgctatg ctttagcaaa gagactagtg   1080

gcattgtgcc cctgctatag ggatctgttg aactttgaac ttgagagaga tgatttaggg   1140

tatctggcag aaaatatttc taagtagcaa agcattcaag atatggcctg gctccttcta   1200

acagtgtatg ctcatatttc tgaggaaaga gattatctga aactggaact tacatttaaa   1260

agggaaatgg agtattaaag tttggaaatg tgcagcctag ccatgtatta gaaaagaaaa   1320

aaccattttc tggggaggaa ttcaacctag ctgcaaaaat ttgtgtaagt aaagaggagc   1380

cgtatgttaa cagccaagac aatgggaaaa atgcccccaa gacatttcag agactttcgt   1440

ggcagcccct ctcatcacag gcctggaggc ctaggaggga aaaacagttt tgtgggtcag   1500

gcttagggcc ctgctattct gtgcagcctt gggaccctgt tccctgtgct ttagctgctc   1560

cagctccagc catggctaaa aggactccag atatgtttca ggttgctgct ccagagggta   1620

taagacacaa gccttggagg cttccagatg gtgttaagcc tgcaggtgct cagagggcaa   1680

gagttgaggc ttgggagcct ccattctttc agatttctga ggatgtatgg aaacaactgg   1740

atatccaggc agaaatttgc ttcaggggcg gagcccttgt ggagaacctc tactagggta   1800

ctgtggaggg gaaatatggg gttgaagtcc ccacaaagag tctccactgg ggcactgcca   1860

agtggagctg tgagaagagg gccactgtcc tccacacccc agaatggtag ctccatcaac   1920

agtttgcact gtgtgcttgg aaaagccaca ggcactcaac accagcctgt gagagcggcc   1980

atggggcact aagccctgca gagccgccag aagcagagct gtccaagacc ttgggagcct   2040

accccttgca tcagtgtggc ctggatgtta gacatggaat caaaggatat tattttggag   2100

ctctaagatt taatgactgc cctgctgggt ttcggacttg catggggcct gtaacccctt   2160

tgttttggcc aatgtctccc ttttggaaca ggaacattta cccaatgcct gtacccttat   2220

tgtatcctag atgtaactaa cttgcttttg attttacagg ctcataggca gaagggactg   2280

ccttatctca gatgaaactt tggacttgga cttttgagtt aatgctgaaa tgagttaaga   2340

ctttgggaga ctgtttggaa agcataattg tgttttgaaa tgtgaggaca tgatatttgg   2400

gatgggccag gagtggaatg atatggtttg gctctgtgtc cccacccaaa tttcatgtca   2460

aattgtaatc ttcaatgttg gaggagggtc ctggtgggaa ggtaattgga tcatgggggc   2520

agacttctcc tttgctgttc tcatgatgag tgagttctca tgatacttga ttgtttaaaa   2580

gtgtatagca tttccccctt tgctctctct ctcctgccag ccatgtgaag atgtgcttgc   2640

ttcccctttg ccttctgcca tgattctaag tttcctgagg cctccccaga agcagaagca   2700

tgtaaagccc acagaaccgt gagttgatta aatctctttt ctttataaat t            2751


<210>  2187
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  2187

Met Gly Leu Leu Ala Phe Arg Asp Val Ala Leu Glu Phe Ser Pro Glu 
1               5                   10                  15


Glu Trp Glu Cys Leu Asp Pro Ala Gln Arg Ser Leu Tyr Arg Asp Val 
            20                  25                  30


Met Leu Glu Asn Tyr Arg Asn Leu Ile Ser Leu Gly Leu Ala Met Ser 
        35                  40                  45


Lys Pro Glu Leu Ile Ile Cys Leu Glu Ala Arg Lys Glu Pro Trp Asn 
    50                  55                  60


Val Asn Thr Glu Lys Thr Ala Arg His Ser Val Glu Thr Arg Phe Arg 
65                  70                  75                  80


His Val Gly Gln Ala Gly Leu Lys Leu Leu Thr Ser Gly Asp Pro Pro 
                85                  90                  95


Ala Leu Ala Ser Gln Ser Ala Gly Ile Thr Gly Thr Gly His His Cys 
            100                 105                 110


Gln Pro Ile Cys Val Phe 
        115


<210>  2188
<211>  683
<212>  DNA
<213>  Homo sapiens

<400>  2188
agagaggaag gggcggcctt ggggatctgg cggggccttt gtctccttgc ggccggcggg     60

gtgctgggtt cccgtctgct gcctctcgga gagtcccggg tgactgccgc aggctccatc    120

gccctgtggc ctgcaggtat tgcgagattt atagggagga cgctgggacc cccaaaagct    180

gggaaatggg actattggca ttcagggatg tggctctaga attctctcca gaggagtggg    240

aatgcctgga cccagctcag cggagtttgt atagggatgt gatgttagag aactacagaa    300

acctgatctc ccttggtgag gatagcttca atatgcaatt cctatttcac agtcttgcta    360

tgtctaagcc agaactgatc atctgtctgg aggcaaggaa agagccctgg aacgtgaaca    420

cagagaagac agccagacac tcagttttgt cttcttatct tactgaagac attttgccag    480

agcagggcct gcaagtttca ttccaaaaag tgatgctgag aagatatgaa agatgttgtc    540

ttgagaaatt acgcttaagg aatgactggg aaattgtggc catgtgaaga tgtgcttgct    600

tcccctttgc cttctgccat gattctaagt ttcctgaggc ctccccagaa gcagaagcat    660

gtaaagccca cagaaccgtg agt                                            683


<210>  2189
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  2189

Met Gly Leu Leu Ala Phe Arg Asp Val Ala Leu Glu Phe Ser Pro Glu 
1               5                   10                  15


Glu Trp Glu Cys Leu Asp Pro Ala Gln Arg Ser Leu Tyr Arg Asp Val 
            20                  25                  30


Met Leu Glu Asn Tyr Arg Asn Leu Ile Ser Leu Gly Glu Asp Ser Phe 
        35                  40                  45


Asn Met Gln Phe Leu Phe His Ser Leu Ala Met Ser Lys Pro Glu Leu 
    50                  55                  60


Ile Ile Cys Leu Glu Ala Arg Lys Glu Pro Trp Asn Val Asn Thr Glu 
65                  70                  75                  80


Lys Thr Ala Arg His Ser Val Leu Ser Ser Tyr Leu Thr Glu Asp Ile 
                85                  90                  95


Leu Pro Glu Gln Gly Leu Gln Val Ser Phe Gln Lys Val Met Leu Arg 
            100                 105                 110


Arg Tyr Glu Arg Cys Cys Leu Glu Lys Leu Arg Leu Arg Asn Asp Trp 
        115                 120                 125


Glu Ile Val Ala Met 
    130


<210>  2190
<211>  589
<212>  DNA
<213>  Homo sapiens

<400>  2190
ggcggggtgc tgggttcccg tctgctgcct ctcggagagt cccgggtgac tgccgcaggc     60

tccatcgccc tgtggcctgc aggtattgcg agatttatag ggaggacgct gggaccccca    120

aaagctggga aatgggacta ttggcattca gggatgtggc tctagaattc tctccagagg    180

agtgggaatg cctggaccca gctcagcgga gtttgtatag ggatgtgatg ttagagaact    240

acagaaacct gatctccctt ggtgaggata gcttcaatat gcaattccta tttcacagtc    300

ttgctatgtc taagccagaa ctgatcatct gtctggaggc aaggaaagag ccctggaacg    360

tgaacacaga gaagacagcc agacactcag ttttgtcttc ttatcttact gaagacattt    420

tgccagagca gggcctgcaa gtttcattcc aaaaagtgat gctgagaaga tatgaaagat    480

gttgtcttga gaaattacgc ttaaggaatg actgggaaat tgtgggtgag tggaaagggc    540

agaaggcaag ttataatgga cttgacctat gctcagcaac tactcatag                589


<210>  2191
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  2191

Met Gly Leu Leu Ala Phe Arg Asp Val Ala Leu Glu Phe Ser Pro Glu 
1               5                   10                  15


Glu Trp Glu Cys Leu Asp Pro Ala Gln Arg Ser Leu Tyr Arg Asp Val 
            20                  25                  30


Met Leu Glu Asn Tyr Arg Asn Leu Ile Ser Leu Gly Glu Asp Ser Phe 
        35                  40                  45


Asn Met Gln Phe Leu Phe His Ser Leu Ala Met Ser Lys Pro Glu Leu 
    50                  55                  60


Ile Ile Cys Leu Glu Ala Arg Lys Glu Pro Trp Asn Val Asn Thr Glu 
65                  70                  75                  80


Lys Thr Ala Arg His Ser Val Leu Ser Ser Tyr Leu Thr Glu Asp Ile 
                85                  90                  95


Leu Pro Glu Gln Gly Leu Gln Val Ser Phe Gln Lys Val Met Leu Arg 
            100                 105                 110


Arg Tyr Glu Arg Cys Cys Leu Glu Lys Leu Arg Leu Arg Asn Asp Trp 
        115                 120                 125


Glu Ile Val Gly Glu Trp Lys Gly Gln Lys Ala Ser Tyr Asn Gly Leu 
    130                 135                 140


Asp Leu Cys Ser Ala Thr Thr 
145                 150


<210>  2192
<211>  2652
<212>  DNA
<213>  Homo sapiens

<400>  2192
caggatgcgg ggctggaccc gcagccagac cccgggccgc ctggcttgtc cctgccccgc     60

cgcttcggcc aggcccggaa ccctttctgg gcagctctgc ctctgtagac ccgcatctcc    120

ctcggatcgt gcggtgccga cgggagggtc ctcaggggag agtcccgact tggggttcgg    180

ggttcctgcg tgggaggagc tgtggattca gtgtcatttg aagatgtggc tgtggccttt    240

actcaggagg agtgggcttt gctggatcct tctcaaaaga atctctacag agatgtgatg    300

caagaaatct tcaggaacct ggcttctgta ggaaacaaat cagaagacca gaatatccaa    360

gatgacttca aaaatcctgg gagaaatcta agcagtcatg tggtagagag actgtttgaa    420

attaaagaag gcagtcaata tggagaaacc ttcagccagg attcaaattt gaatctgaat    480

aagaaagttt ctactggagt aaagccatgt gaatgcagtg tgtgtggaaa agtcttcata    540

tgtcattcag cccttcatag gcacatcctg tctcacattg gaaacaaact atttgagtgt    600

gaggaatgtc cagagaagtt atatcattgc aaacaatgtg ggaaagcctt tatctctctc    660

accagtgttg acagacacat ggtaacacac actagtaatg ggccttataa gggtccagtg    720

tatgagaagc cttttgattt tcctagtgta tttcaaatgc ctcagagcac ttacactgga    780

gagaaaacat ataaatgtaa acattgtgat aaagccttca attattcaag ttatcttcgt    840

gaacatgaaa gaactcatac tggagagaaa ccctatgcat gtaagaaatg tggtaaatca    900

ttcacttttt ccagttctct tcgccaacat gaaagatctc atactggaga gaaaccctat    960

gaatgtaagg aatgtggcaa agccttcagt cgttccactt acttgggaat acatgaaaga   1020

acgcatactg gagaaaaacc ctatgaatgt ataaaatgtg gcaaagcctt tagatgttcc   1080

agagtcctca gagtccatga aaggactcac agtggagaaa agccctatga atgtaaacaa   1140

tgtggtaaag ccttcaaata ttctagtaac ctatgtgagc atgaaagaac tcacactgga   1200

gtgaaacctt atggatgtaa ggaatgtggt aagtcgttta cttcttccag tgcccttcga   1260

agccatgaaa ggactcatac tggagaaaaa ccctatgaat gtaagaaatg tggtaaagcc   1320

ttcagttgtt ccagttccct tcgaaagcat gaaagagctt atatgtggta aaaaacaaca   1380

acaacaaaac acctctgtca atgtaagaag tgtgttaaag ctttcagtta ttctagtttc   1440

attagaacac gtgaaaaaat taaaaactca aattagagag aaacccaaca catgtaagga   1500

agattagaat gtatgcaatt ttcctagttc ccttctaaaa cttagaagga cccgtcctgg   1560

gaaagaacgt cataaaatac gaaaaatgtg ttagaacact ttattttccc agccgctttc   1620

aaatatattt ttatcagtgg ttcattgtta aagaaggtgt ctatacttta gattttcagt   1680

tttttgcagg gaatcatgga gctgagaatt tcacagatac tttataagcc atagtacatg   1740

agcttaatag gctgtgtttt gtttctcatc agttaacata atttttgtct attcatttaa   1800

aaatttgttg gatccctaga ctaagttgaa atgtatttct aatagtaggc aattttaatt   1860

ttcatgtagt tgtttaattg ttctctaatt aatggaccaa tgaaaaatga gttcatgtgt   1920

gtgtgtgtgt gtgtgtgtgt gtgtgtgtat tctacctttt tatgggaaaa ctactttttt   1980

gttgtaaaga ttttcttctg ttttctttgc taataaagaa ttgttattaa tttgcatgta   2040

tgtgaagttt atatagtctc atgtacattg ttattttcat tttctttcct ttattctgtc   2100

atgagttttg gctgttactt gcatagttca cttttttaaa aaatgttatg tttttagaga   2160

gggtctcact ttgtcagcta ggctgaagtg tagtggtaat aatagtctta gctcactgca   2220

gcctcaaatt cctgggctca agtgattctc ccaccttagc ctcctatgta gctggagcta   2280

cagacacatg ccaccatgct cagctaatta tataatttta aaaatttttt atagagatgg   2340

gatctcgctg tattgtctag gctggtattg aattcctggc ctcaagctat cctcctgcct   2400

cagcctgtct acatgttggg gttactgaca tgagctacca cacctggccc actttttact   2460

ttgaattaag aagagagaac tgtgattgga cagtatgctt gtctaatctg cgtgtgaaag   2520

cattcagtct caccatcaag tatattgtgg atttttcata aatattctca aacaggctca   2580

ggaagttttc ttgtgttttt tatttattgt ttcatggtaa aggagtgttg aactcttatg   2640

acatgttttt tt                                                       2652


<210>  2193
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  2193

Met Gln Glu Ile Phe Arg Asn Leu Ala Ser Val Gly Asn Lys Ser Glu 
1               5                   10                  15


Asp Gln Asn Ile Gln Asp Asp Phe Lys Asn Pro Gly Arg Asn Leu Ser 
            20                  25                  30


Ser His Val Val Glu Arg Leu Phe Glu Ile Lys Glu Gly Ser Gln Tyr 
        35                  40                  45


Gly Glu Thr Phe Ser Gln Asp Ser Asn Leu Asn Leu Asn Lys Lys Val 
    50                  55                  60


Ser Thr Gly Val Lys Pro Cys Glu Cys Ser Val Cys Gly Lys Val Phe 
65                  70                  75                  80


Ile Cys His Ser Ala Leu His Arg His Ile Leu Ser His Ile Gly Asn 
                85                  90                  95


Lys Leu Phe Glu Cys Glu Glu Cys Pro Glu Lys Leu Tyr His Cys Lys 
            100                 105                 110


Gln Cys Gly Lys Ala Phe Ile Ser Leu Thr Ser Val Asp Arg His Met 
        115                 120                 125


Val Thr His Thr Ser Asn Gly Pro Tyr Lys Gly Pro Val Tyr Glu Lys 
    130                 135                 140


Pro Phe Asp Phe Pro Ser Val Phe Gln Met Pro Gln Ser Thr Tyr Thr 
145                 150                 155                 160


Gly Glu Lys Thr Tyr Lys Cys Lys His Cys Asp Lys Ala Phe Asn Tyr 
                165                 170                 175


Ser Ser Tyr Leu Arg Glu His Glu Arg Thr His Thr Gly Glu Lys Pro 
            180                 185                 190


Tyr Ala Cys Lys Lys Cys Gly Lys Ser Phe Thr Phe Ser Ser Ser Leu 
        195                 200                 205


Arg Gln His Glu Arg Ser His Thr Gly Glu Lys Pro Tyr Glu Cys Lys 
    210                 215                 220


Glu Cys Gly Lys Ala Phe Ser Arg Ser Thr Tyr Leu Gly Ile His Glu 
225                 230                 235                 240


Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Ile Lys Cys Gly Lys 
                245                 250                 255


Ala Phe Arg Cys Ser Arg Val Leu Arg Val His Glu Arg Thr His Ser 
            260                 265                 270


Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys Ala Phe Lys Tyr 
        275                 280                 285


Ser Ser Asn Leu Cys Glu His Glu Arg Thr His Thr Gly Val Lys Pro 
    290                 295                 300


Tyr Gly Cys Lys Glu Cys Gly Lys Ser Phe Thr Ser Ser Ser Ala Leu 
305                 310                 315                 320


Arg Ser His Glu Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys 
                325                 330                 335


Lys Cys Gly Lys Ala Phe Ser Cys Ser Ser Ser Leu Arg Lys His Glu 
            340                 345                 350


Arg Ala Tyr Met Trp 
        355


<210>  2194
<211>  2519
<212>  DNA
<213>  Homo sapiens

<400>  2194
gcgaaaggag ggagcagctt ccgggacctg gcgcggcttt tgtgttgggc agcgcgaatg     60

tggcgagctc ggattcagtg tcatttgaag atgtggctgt ggcctttact caggaggagt    120

gggctttgct ggatccttct caaaagaatc tctacagaga tgtgatgcaa gaaatcttca    180

ggaacctggc ttctgtagga aacaaatcag aagaccagaa tatccaagat gacttcaaaa    240

atcctgggag aaatctaagc agtcatgtgg tagagagact gtttgaaatt aaagaaggca    300

gtcaatatgg agaaaccttc agccaggatt caaatttgaa tctgaataag aaagtttcta    360

ctggagtaaa gccatgtgaa tgcagtgtgt gtggaaaagt cttcatatgt cattcagccc    420

ttcataggca catcctgtct cacattggaa acaaactatt tgagtgtgag gaatgtccag    480

agaagttata tcattgcaaa caatgtggga aagcctttat ctctctcacc agtgttgaca    540

gacacatggt aacacacact agtaatgggc cttataaggg tccagtgtat gagaagcctt    600

ttgattttcc tagtgtattt caaatgcctc agagcactta cactggagag aaaacatata    660

aatgtaaaca ttgtgataaa gccttcaatt attcaagtta tcttcgtgaa catgaaagaa    720

ctcatactgg agagaaaccc tatgcatgta agaaatgtgg taaatcattc actttttcca    780

gttctcttcg ccaacatgaa agatctcata ctggagagaa accctatgaa tgtaaggaat    840

gtggcaaagc cttcagtcgt tccacttact tgggaataca tgaaagaacg catactggag    900

aaaaacccta tgaatgtata aaatgtggca aagcctttag atgttccaga gtcctcagag    960

tccatgaaag gactcacagt ggagaaaagc cctatgaatg taaacaatgt ggtaaagcct   1020

tcaaatattc tagtaaccta tgtgagcatg aaagaactca cactggagtg aaaccttatg   1080

gatgtaagga atgtggtaag tcgtttactt cttccagtgc ccttcgaagc catgaaagga   1140

ctcatactgg agaaaaaccc tatgaatgta agaaatgtgg taaagccttc agttgttcca   1200

gttcccttcg aaagcatgaa agagcttata tgtggtaaaa aacaacaaca acaaaacacc   1260

tctgtcaatg taagaagtgt gttaaagctt tcagttattc tagtttcatt agaacacgtg   1320

aaaaaattaa aaactcaaat tagagagaaa cccaacacat gtaaggaaga ttagaatgta   1380

tgcaattttc ctagttccct tctaaaactt agaaggaccc gtcctgggaa agaacgtcat   1440

aaaatacgaa aaatgtgtta gaacacttta ttttcccagc cgctttcaaa tatattttta   1500

tcagtggttc attgttaaag aaggtgtcta tactttagat tttcagtttt ttgcagggaa   1560

tcatggagct gagaatttca cagatacttt ataagccata gtacatgagc ttaataggct   1620

gtgttttgtt tctcatcagt taacataatt tttgtctatt catttaaaaa tttgttggat   1680

ccctagacta agttgaaatg tatttctaat agtaggcaat tttaattttc atgtagttgt   1740

ttaattgttc tctaattaat ggaccaatga aaaatgagtt catgtgtgtg tgtgtgtgtg   1800

tgtgtgtgtg tgtgtattct acctttttat gggaaaacta cttttttgtt gtaaagattt   1860

tcttctgttt tctttgctaa taaagaattg ttattaattt gcatgtatgt gaagtttata   1920

tagtctcatg tacattgtta ttttcatttt ctttccttta ttctgtcatg agttttggct   1980

gttacttgca tagttcactt ttttaaaaaa tgttatgttt ttagagaggg tctcactttg   2040

tcagctaggc tgaagtgtag tggtaataat agtcttagct cactgcagcc tcaaattcct   2100

gggctcaagt gattctccca ccttagcctc ctatgtagct ggagctacag acacatgcca   2160

ccatgctcag ctaattatat aattttaaaa attttttata gagatgggat ctcgctgtat   2220

tgtctaggct ggtattgaat tcctggcctc aagctatcct cctgcctcag cctgtctaca   2280

tgttggggtt actgacatga gctaccacac ctggcccact ttttactttg aattaagaag   2340

agagaactgt gattggacag tatgcttgtc taatctgcgt gtgaaagcat tcagtctcac   2400

catcaagtat attgtggatt tttcataaat attctcaaac aggctcagga agttttcttg   2460

tgttttttat ttattgtttc atggtaaagg agtgttgaac tcttatgaca tgttttttt    2519


<210>  2195
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  2195

Met Gln Glu Ile Phe Arg Asn Leu Ala Ser Val Gly Asn Lys Ser Glu 
1               5                   10                  15


Asp Gln Asn Ile Gln Asp Asp Phe Lys Asn Pro Gly Arg Asn Leu Ser 
            20                  25                  30


Ser His Val Val Glu Arg Leu Phe Glu Ile Lys Glu Gly Ser Gln Tyr 
        35                  40                  45


Gly Glu Thr Phe Ser Gln Asp Ser Asn Leu Asn Leu Asn Lys Lys Val 
    50                  55                  60


Ser Thr Gly Val Lys Pro Cys Glu Cys Ser Val Cys Gly Lys Val Phe 
65                  70                  75                  80


Ile Cys His Ser Ala Leu His Arg His Ile Leu Ser His Ile Gly Asn 
                85                  90                  95


Lys Leu Phe Glu Cys Glu Glu Cys Pro Glu Lys Leu Tyr His Cys Lys 
            100                 105                 110


Gln Cys Gly Lys Ala Phe Ile Ser Leu Thr Ser Val Asp Arg His Met 
        115                 120                 125


Val Thr His Thr Ser Asn Gly Pro Tyr Lys Gly Pro Val Tyr Glu Lys 
    130                 135                 140


Pro Phe Asp Phe Pro Ser Val Phe Gln Met Pro Gln Ser Thr Tyr Thr 
145                 150                 155                 160


Gly Glu Lys Thr Tyr Lys Cys Lys His Cys Asp Lys Ala Phe Asn Tyr 
                165                 170                 175


Ser Ser Tyr Leu Arg Glu His Glu Arg Thr His Thr Gly Glu Lys Pro 
            180                 185                 190


Tyr Ala Cys Lys Lys Cys Gly Lys Ser Phe Thr Phe Ser Ser Ser Leu 
        195                 200                 205


Arg Gln His Glu Arg Ser His Thr Gly Glu Lys Pro Tyr Glu Cys Lys 
    210                 215                 220


Glu Cys Gly Lys Ala Phe Ser Arg Ser Thr Tyr Leu Gly Ile His Glu 
225                 230                 235                 240


Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Ile Lys Cys Gly Lys 
                245                 250                 255


Ala Phe Arg Cys Ser Arg Val Leu Arg Val His Glu Arg Thr His Ser 
            260                 265                 270


Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys Ala Phe Lys Tyr 
        275                 280                 285


Ser Ser Asn Leu Cys Glu His Glu Arg Thr His Thr Gly Val Lys Pro 
    290                 295                 300


Tyr Gly Cys Lys Glu Cys Gly Lys Ser Phe Thr Ser Ser Ser Ala Leu 
305                 310                 315                 320


Arg Ser His Glu Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys 
                325                 330                 335


Lys Cys Gly Lys Ala Phe Ser Cys Ser Ser Ser Leu Arg Lys His Glu 
            340                 345                 350


Arg Ala Tyr Met Trp 
        355


<210>  2196
<211>  2668
<212>  DNA
<213>  Homo sapiens

<400>  2196
gtactctcaa gcgcgccgcg aaaggaggga gcagcttccg ggacctggcg cggcttttgt     60

gttgggcagc gcgaatgtgg cgagctcggt gcgtctccgc tgctccttcc ccttatccct    120

gggaggtcca agtggtcccg cggcagcttc tgttgctctg ggacctgcag gtcccggaag    180

gtccttaggg aggaccccag acaccggaga ctgggaaatg gattcagtgt catttgaaga    240

tgtggctgtg gcctttactc aggaggagtg ggctttgctg gatccttctc aaaagaatct    300

ctacagagat gtgatgcaag aaatcttcag gaacctggct tctgtaggaa acaaatcaga    360

agaccagaat atccaagatg acttcaaaaa tcctgggaga aatctaagca gtcatgtggt    420

agagagactg tttgaaatta aagaaggcag tcaatatgga gaaaccttca gccaggattc    480

aaatttgaat ctgaataaga aagtttctac tggagtaaag ccatgtgaat gcagtgtgtg    540

tggaaaagtc ttcatatgtc attcagccct tcataggcac atcctgtctc acattggaaa    600

caaactattt gagtgtgagg aatgtccaga gaagttatat cattgcaaac aatgtgggaa    660

agcctttatc tctctcacca gtgttgacag acacatggta acacacacta gtaatgggcc    720

ttataagggt ccagtgtatg agaagccttt tgattttcct agtgtatttc aaatgcctca    780

gagcacttac actggagaga aaacatataa atgtaaacat tgtgataaag ccttcaatta    840

ttcaagttat cttcgtgaac atgaaagaac tcatactgga gagaaaccct atgcatgtaa    900

gaaatgtggt aaatcattca ctttttccag ttctcttcgc caacatgaaa gatctcatac    960

tggagagaaa ccctatgaat gtaaggaatg tggcaaagcc ttcagtcgtt ccacttactt   1020

gggaatacat gaaagaacgc atactggaga aaaaccctat gaatgtataa aatgtggcaa   1080

agcctttaga tgttccagag tcctcagagt ccatgaaagg actcacagtg gagaaaagcc   1140

ctatgaatgt aaacaatgtg gtaaagcctt caaatattct agtaacctat gtgagcatga   1200

aagaactcac actggagtga aaccttatgg atgtaaggaa tgtggtaagt cgtttacttc   1260

ttccagtgcc cttcgaagcc atgaaaggac tcatactgga gaaaaaccct atgaatgtaa   1320

gaaatgtggt aaagccttca gttgttccag ttcccttcga aagcatgaaa gagcttatat   1380

gtggtaaaaa acaacaacaa caaaacacct ctgtcaatgt aagaagtgtg ttaaagcttt   1440

cagttattct agtttcatta gaacacgtga aaaaattaaa aactcaaatt agagagaaac   1500

ccaacacatg taaggaagat tagaatgtat gcaattttcc tagttccctt ctaaaactta   1560

gaaggacccg tcctgggaaa gaacgtcata aaatacgaaa aatgtgttag aacactttat   1620

tttcccagcc gctttcaaat atatttttat cagtggttca ttgttaaaga aggtgtctat   1680

actttagatt ttcagttttt tgcagggaat catggagctg agaatttcac agatacttta   1740

taagccatag tacatgagct taataggctg tgttttgttt ctcatcagtt aacataattt   1800

ttgtctattc atttaaaaat ttgttggatc cctagactaa gttgaaatgt atttctaata   1860

gtaggcaatt ttaattttca tgtagttgtt taattgttct ctaattaatg gaccaatgaa   1920

aaatgagttc atgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtattcta cctttttatg   1980

ggaaaactac ttttttgttg taaagatttt cttctgtttt ctttgctaat aaagaattgt   2040

tattaatttg catgtatgtg aagtttatat agtctcatgt acattgttat tttcattttc   2100

tttcctttat tctgtcatga gttttggctg ttacttgcat agttcacttt tttaaaaaat   2160

gttatgtttt tagagagggt ctcactttgt cagctaggct gaagtgtagt ggtaataata   2220

gtcttagctc actgcagcct caaattcctg ggctcaagtg attctcccac cttagcctcc   2280

tatgtagctg gagctacaga cacatgccac catgctcagc taattatata attttaaaaa   2340

ttttttatag agatgggatc tcgctgtatt gtctaggctg gtattgaatt cctggcctca   2400

agctatcctc ctgcctcagc ctgtctacat gttggggtta ctgacatgag ctaccacacc   2460

tggcccactt tttactttga attaagaaga gagaactgtg attggacagt atgcttgtct   2520

aatctgcgtg tgaaagcatt cagtctcacc atcaagtata ttgtggattt ttcataaata   2580

ttctcaaaca ggctcaggaa gttttcttgt gttttttatt tattgtttca tggtaaagga   2640

gtgttgaact cttatgacat gttttttt                                      2668


<210>  2197
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  2197

Met Asp Ser Val Ser Phe Glu Asp Val Ala Val Ala Phe Thr Gln Glu 
1               5                   10                  15


Glu Trp Ala Leu Leu Asp Pro Ser Gln Lys Asn Leu Tyr Arg Asp Val 
            20                  25                  30


Met Gln Glu Ile Phe Arg Asn Leu Ala Ser Val Gly Asn Lys Ser Glu 
        35                  40                  45


Asp Gln Asn Ile Gln Asp Asp Phe Lys Asn Pro Gly Arg Asn Leu Ser 
    50                  55                  60


Ser His Val Val Glu Arg Leu Phe Glu Ile Lys Glu Gly Ser Gln Tyr 
65                  70                  75                  80


Gly Glu Thr Phe Ser Gln Asp Ser Asn Leu Asn Leu Asn Lys Lys Val 
                85                  90                  95


Ser Thr Gly Val Lys Pro Cys Glu Cys Ser Val Cys Gly Lys Val Phe 
            100                 105                 110


Ile Cys His Ser Ala Leu His Arg His Ile Leu Ser His Ile Gly Asn 
        115                 120                 125


Lys Leu Phe Glu Cys Glu Glu Cys Pro Glu Lys Leu Tyr His Cys Lys 
    130                 135                 140


Gln Cys Gly Lys Ala Phe Ile Ser Leu Thr Ser Val Asp Arg His Met 
145                 150                 155                 160


Val Thr His Thr Ser Asn Gly Pro Tyr Lys Gly Pro Val Tyr Glu Lys 
                165                 170                 175


Pro Phe Asp Phe Pro Ser Val Phe Gln Met Pro Gln Ser Thr Tyr Thr 
            180                 185                 190


Gly Glu Lys Thr Tyr Lys Cys Lys His Cys Asp Lys Ala Phe Asn Tyr 
        195                 200                 205


Ser Ser Tyr Leu Arg Glu His Glu Arg Thr His Thr Gly Glu Lys Pro 
    210                 215                 220


Tyr Ala Cys Lys Lys Cys Gly Lys Ser Phe Thr Phe Ser Ser Ser Leu 
225                 230                 235                 240


Arg Gln His Glu Arg Ser His Thr Gly Glu Lys Pro Tyr Glu Cys Lys 
                245                 250                 255


Glu Cys Gly Lys Ala Phe Ser Arg Ser Thr Tyr Leu Gly Ile His Glu 
            260                 265                 270


Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Ile Lys Cys Gly Lys 
        275                 280                 285


Ala Phe Arg Cys Ser Arg Val Leu Arg Val His Glu Arg Thr His Ser 
    290                 295                 300


Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Gly Lys Ala Phe Lys Tyr 
305                 310                 315                 320


Ser Ser Asn Leu Cys Glu His Glu Arg Thr His Thr Gly Val Lys Pro 
                325                 330                 335


Tyr Gly Cys Lys Glu Cys Gly Lys Ser Phe Thr Ser Ser Ser Ala Leu 
            340                 345                 350


Arg Ser His Glu Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys 
        355                 360                 365


Lys Cys Gly Lys Ala Phe Ser Cys Ser Ser Ser Leu Arg Lys His Glu 
    370                 375                 380


Arg Ala Tyr Met Trp 
385


<210>  2198
<211>  1527
<212>  DNA
<213>  Homo sapiens

<400>  2198
cgccggaaag gagagggcgg cttccgggat ctgcctggcg gttgctttgt ctctccttcg     60

ccggagccgg ctcttcctgt tagtctccgc tgctagttct tggctctggg aggcccaggt    120

ggctctgcag cagcctctgc caccctgtga cctgcgagta ttgggacatc cctagctgac    180

gccaggacac ccgggaagcc gaggaatgga ctcggtggct tttgaggatg tggctgtgaa    240

ctttacccag gaggaatggg ctttgctaga ttcttctcag aagaatctct acagagaagt    300

gatgcaggaa acctgcagga acctggcttc tgtaggaagc caatggaaag accagaatat    360

tgaagatcac ttcgaaaaac ctgggaaaga tataagaaat catatcgtac agagactgtg    420

tgaaagtaaa gaagatggtc agtatggaga agttgtcagc caaattccaa atcttgatct    480

gaacgagaac atttctactg gattaaaacc atgtgaatgc agtatttgtg gaaaagtctt    540

tgtacgtcat tccctcctta ataggcatat cctagctcac tcaggataca aaccatatgg    600

agagaagcaa tataaatgtg aacagtgtgg gaaattcttc gtttctgttc caggtgttag    660

aagacacatg ataatgcaca gtggaaatcc agcttataaa tgtacgatat gtgggaaagc    720

tttttatttt ctcaattcag ttgaaagaca tcagagaact cacacaggag aaaaacccta    780

taaatgtaaa caatgtggta aagcattcac tgtttccggt tcttgtctaa tacatgaacg    840

aactcacact ggagagaaac cctacgaatg taaggaatgt gggaaaacat tcagattttc    900

ttgttctttt aagacgcatg aaaggactca cactggagaa agaccctata aatgtaccaa    960

atgtgataaa gccttcagct gttccacttc ccttcgttac catggaagca ttcatactgg   1020

agagagaccc tatgagtgta aacaatgtgg caaagccttt agtcgtttga gttccctttg   1080

taaccataga agtactcata ccggagagaa accctatgaa tgtaaacaat gtgatcaagc   1140

cttcagtcgc ctcagttccc ttcacctcca cgaaagaatt catactggag aaaaacccta   1200

tgaatgtaag aaatgcggta aagcctacac tcgttccagt caccttactc gccatgaaag   1260

aagtcatgat atagaaaaat aaaataagga gtaagtttaa tttgtatgta ttgttctgtg   1320

attaatggac cagtgagtaa tgattgctaa ttgttgcgat tttcttacta gcctcacttg   1380

gcaaattttg gttatccctt gtccattata cacattccac ctttttttat taaaggaaaa   1440

actactcttg gtgtaaagat gtttattttt tgctaataat gagttggtat taattcctaa   1500

gtacataaag tttatcatag agtatca                                       1527


<210>  2199
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  2199

Met Asp Ser Val Ala Phe Glu Asp Val Ala Val Asn Phe Thr Gln Glu 
1               5                   10                  15


Glu Trp Ala Leu Leu Asp Ser Ser Gln Lys Asn Leu Tyr Arg Glu Val 
            20                  25                  30


Met Gln Glu Thr Cys Arg Asn Leu Ala Ser Val Gly Ser Gln Trp Lys 
        35                  40                  45


Asp Gln Asn Ile Glu Asp His Phe Glu Lys Pro Gly Lys Asp Ile Arg 
    50                  55                  60


Asn His Ile Val Gln Arg Leu Cys Glu Ser Lys Glu Asp Gly Gln Tyr 
65                  70                  75                  80


Gly Glu Val Val Ser Gln Ile Pro Asn Leu Asp Leu Asn Glu Asn Ile 
                85                  90                  95


Ser Thr Gly Leu Lys Pro Cys Glu Cys Ser Ile Cys Gly Lys Val Phe 
            100                 105                 110


Val Arg His Ser Leu Leu Asn Arg His Ile Leu Ala His Ser Gly Tyr 
        115                 120                 125


Lys Pro Tyr Gly Glu Lys Gln Tyr Lys Cys Glu Gln Cys Gly Lys Phe 
    130                 135                 140


Phe Val Ser Val Pro Gly Val Arg Arg His Met Ile Met His Ser Gly 
145                 150                 155                 160


Asn Pro Ala Tyr Lys Cys Thr Ile Cys Gly Lys Ala Phe Tyr Phe Leu 
                165                 170                 175


Asn Ser Val Glu Arg His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr 
            180                 185                 190


Lys Cys Lys Gln Cys Gly Lys Ala Phe Thr Val Ser Gly Ser Cys Leu 
        195                 200                 205


Ile His Glu Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu 
    210                 215                 220


Cys Gly Lys Thr Phe Arg Phe Ser Cys Ser Phe Lys Thr His Glu Arg 
225                 230                 235                 240


Thr His Thr Gly Glu Arg Pro Tyr Lys Cys Thr Lys Cys Asp Lys Ala 
                245                 250                 255


Phe Ser Cys Ser Thr Ser Leu Arg Tyr His Gly Ser Ile His Thr Gly 
            260                 265                 270


Glu Arg Pro Tyr Glu Cys Lys Gln Cys Gly Lys Ala Phe Ser Arg Leu 
        275                 280                 285


Ser Ser Leu Cys Asn His Arg Ser Thr His Thr Gly Glu Lys Pro Tyr 
    290                 295                 300


Glu Cys Lys Gln Cys Asp Gln Ala Phe Ser Arg Leu Ser Ser Leu His 
305                 310                 315                 320


Leu His Glu Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Lys 
                325                 330                 335


Cys Gly Lys Ala Tyr Thr Arg Ser Ser His Leu Thr Arg His Glu Arg 
            340                 345                 350


Ser His Asp Ile Glu Lys 
        355


<210>  2200
<211>  1980
<212>  DNA
<213>  Homo sapiens

<400>  2200
gcctggcggt tgctttgtct ctccttcgcc ggagccggct cttcctgtta gtctccgctg     60

ctagttcttg gctctgggag gcccaggtgg ctctgcagca gcctctgcca ccctgtgacc    120

tgcgagtatt gggacatccc tagctgacgc caggacaccc gggaagccga ggaatggtga    180

gtggactgcg cctggcttcc cgaagtggag aagagggctg gttgaaacct gctgtggcgc    240

gactcgggcc tccacgccat cggctccgga acctgcggac cgagtcgccg tggcgtagcc    300

ggggctcagt cctcttctgt tcagggccgg gccgggcggg gcgggcagcg gaacccctgc    360

atcctgtctg tacctgcggg cgccacttcc gccggccgga gccctgtcgg gaacccctcg    420

cctcccctat ccaggactcg gtggcttttg aggatgtggc tgtgaacttt acccaggagg    480

aatgggcttt gctagattct tctcagaaga atctctacag agaagtgatg caggaaacct    540

gcaggaacct ggcttctgta ggaagccaat ggaaagacca gaatattgaa gatcacttcg    600

aaaaacctgg gaaagatata agaaatcata tcgtacagag actgtgtgaa agtaaagaag    660

atggtcagta tggagaagtt gtcagccaaa ttccaaatct tgatctgaac gagaacattt    720

ctactggatt aaaaccatgt gaatgcagta tttgtggaaa agtctttgta cgtcattccc    780

tccttaatag gcatatccta gctcactcag gatacaaacc atatggagag aagcaatata    840

aatgtgaaca gtgtgggaaa ttcttcgttt ctgttccagg tgttagaaga cacatgataa    900

tgcacagtgg aaatccagct tataaatgta cgatatgtgg gaaagctttt tattttctca    960

attcagttga aagacatcag agaactcaca caggagaaaa accctataaa tgtaaacaat   1020

gtggtaaagc attcactgtt tccggttctt gtctaataca tgaacgaact cacactggag   1080

agaaacccta cgaatgtaag gaatgtggga aaacattcag attttcttgt tcttttaaga   1140

cgcatgaaag gactcacact ggagaaagac cctataaatg taccaaatgt gataaagcct   1200

tcagctgttc cacttccctt cgttaccatg gaagcattca tactggagag agaccctatg   1260

agtgtaaaca atgtggcaaa gcctttagtc gtttgagttc cctttgtaac catagaagta   1320

ctcataccgg agagaaaccc tatgaatgta aacaatgtga tcaagccttc agtcgcctca   1380

gttcccttca cctccacgaa agaattcata ctggagaaaa accctatgaa tgtaagaaat   1440

gcggtaaagc ctacactcgt tccagtcacc ttactcgcca tgaaagaagt catgatatag   1500

aggctgggtg tagtgactca gcctataatc ccagcacttt gggaggccaa ggcgtgtgga   1560

ttgcttgagc ccaggagttc ataaccagcc tggattaaaa caatgtgaaa caacctgggc   1620

aacatggtga aaccctgtct ttacaaaaaa taaaataatg ccgggcacgg tggcttacgc   1680

ctgtaatccc agcactttgg gaggccgagg cgggtggatc acgaggtcag gagatcgaga   1740

ccatcctggc caacacggtg aaaccccgtc tctactaaaa atacaaaaaa ttagctgggc   1800

gtggtggcag acgcctgtgg tcccagttac tcgggaggct gaggcaggag aatggcatga   1860

acccgggagg cggaacttgc agtgagccga gatcgcacca ctgcacttca gcctgggtga   1920

cagagtgaga ctctgtctca aaaaataaga taaaataaaa taaaaaaata attagctggg   1980


<210>  2201
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  2201

Met Val Ser Gly Leu Arg Leu Ala Ser Arg Ser Gly Glu Glu Gly Trp 
1               5                   10                  15


Leu Lys Pro Ala Val Ala Arg Leu Gly Pro Pro Arg His Arg Leu Arg 
            20                  25                  30


Asn Leu Arg Thr Glu Ser Pro Trp Arg Ser Arg Gly Ser Val Leu Phe 
        35                  40                  45


Cys Ser Gly Pro Gly Arg Ala Gly Arg Ala Ala Glu Pro Leu His Pro 
    50                  55                  60


Val Cys Thr Cys Gly Arg His Phe Arg Arg Pro Glu Pro Cys Arg Glu 
65                  70                  75                  80


Pro Leu Ala Ser Pro Ile Gln Asp Ser Val Ala Phe Glu Asp Val Ala 
                85                  90                  95


Val Asn Phe Thr Gln Glu Glu Trp Ala Leu Leu Asp Ser Ser Gln Lys 
            100                 105                 110


Asn Leu Tyr Arg Glu Val Met Gln Glu Thr Cys Arg Asn Leu Ala Ser 
        115                 120                 125


Val Gly Ser Gln Trp Lys Asp Gln Asn Ile Glu Asp His Phe Glu Lys 
    130                 135                 140


Pro Gly Lys Asp Ile Arg Asn His Ile Val Gln Arg Leu Cys Glu Ser 
145                 150                 155                 160


Lys Glu Asp Gly Gln Tyr Gly Glu Val Val Ser Gln Ile Pro Asn Leu 
                165                 170                 175


Asp Leu Asn Glu Asn Ile Ser Thr Gly Leu Lys Pro Cys Glu Cys Ser 
            180                 185                 190


Ile Cys Gly Lys Val Phe Val Arg His Ser Leu Leu Asn Arg His Ile 
        195                 200                 205


Leu Ala His Ser Gly Tyr Lys Pro Tyr Gly Glu Lys Gln Tyr Lys Cys 
    210                 215                 220


Glu Gln Cys Gly Lys Phe Phe Val Ser Val Pro Gly Val Arg Arg His 
225                 230                 235                 240


Met Ile Met His Ser Gly Asn Pro Ala Tyr Lys Cys Thr Ile Cys Gly 
                245                 250                 255


Lys Ala Phe Tyr Phe Leu Asn Ser Val Glu Arg His Gln Arg Thr His 
            260                 265                 270


Thr Gly Glu Lys Pro Tyr Lys Cys Lys Gln Cys Gly Lys Ala Phe Thr 
        275                 280                 285


Val Ser Gly Ser Cys Leu Ile His Glu Arg Thr His Thr Gly Glu Lys 
    290                 295                 300


Pro Tyr Glu Cys Lys Glu Cys Gly Lys Thr Phe Arg Phe Ser Cys Ser 
305                 310                 315                 320


Phe Lys Thr His Glu Arg Thr His Thr Gly Glu Arg Pro Tyr Lys Cys 
                325                 330                 335


Thr Lys Cys Asp Lys Ala Phe Ser Cys Ser Thr Ser Leu Arg Tyr His 
            340                 345                 350


Gly Ser Ile His Thr Gly Glu Arg Pro Tyr Glu Cys Lys Gln Cys Gly 
        355                 360                 365


Lys Ala Phe Ser Arg Leu Ser Ser Leu Cys Asn His Arg Ser Thr His 
    370                 375                 380


Thr Gly Glu Lys Pro Tyr Glu Cys Lys Gln Cys Asp Gln Ala Phe Ser 
385                 390                 395                 400


Arg Leu Ser Ser Leu His Leu His Glu Arg Ile His Thr Gly Glu Lys 
                405                 410                 415


Pro Tyr Glu Cys Lys Lys Cys Gly Lys Ala Tyr Thr Arg Ser Ser His 
            420                 425                 430


Leu Thr Arg His Glu Arg Ser His Asp Ile Glu Ala Gly Cys Ser Asp 
        435                 440                 445


Ser Ala Tyr Asn Pro Ser Thr Leu Gly Gly Gln Gly Val Trp Ile Ala 
    450                 455                 460


<210>  2202
<211>  489
<212>  DNA
<213>  Homo sapiens

<400>  2202
caggtggctc tgcagcagcc tctgccaccc tgtgacctgc gagtattggg acatccctag     60

ctgacgccag gacacccggg aagccgagga atggactcgg tggcttttga ggatgtggct    120

gtgaacttta cccaggagga atgggctttg ctagattctt ctcagaagaa tctctacaga    180

gaagtgatgc aggaaacctg caggaacctg gcttctgtag aaatcatatc gtacagagac    240

tgtgtgaaag taaagaagat ggtcagtatg gagaagttgt cagccaaatt ccaaatcttg    300

atctgaacga gaacatttct actggattaa aaccatgtga atgcagtatt tgtggaaaag    360

tctttgtacg tcattccctc cttaataggc atatcctagc tcactcagga tacaaaccat    420

atggagagaa gcaatataaa tgtgaacagt gtgggaaatt cttcgtttct gttccaggtg    480

ttagaagac                                                            489


<210>  2203
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  2203

Met Gly Phe Ala Arg Phe Phe Ser Glu Glu Ser Leu Gln Arg Ser Asp 
1               5                   10                  15


Ala Gly Asn Leu Gln Glu Pro Gly Phe Cys Arg Asn His Ile Val Gln 
            20                  25                  30


Arg Leu Cys Glu Ser Lys Glu Asp Gly Gln Tyr Gly Glu Val Val Ser 
        35                  40                  45


Gln Ile Pro Asn Leu Asp Leu Asn Glu Asn Ile Ser Thr Gly Leu Lys 
    50                  55                  60


Pro Cys Glu Cys Ser Ile Cys Gly Lys Val Phe Val Arg His Ser Leu 
65                  70                  75                  80


Leu Asn Arg His Ile Leu Ala His Ser Gly Tyr Lys Pro Tyr Gly Glu 
                85                  90                  95


Lys Gln Tyr Lys Cys Glu Gln Cys Gly Lys Phe Phe Val Ser Val Pro 
            100                 105                 110


Gly Val Arg 
        115


<210>  2204
<211>  487
<212>  DNA
<213>  Homo sapiens

<400>  2204
ggcggttgct ttgtctctcc ttcgccggag ccggctcttc ctgttagtct ccgctgctag     60

ttcttggctc tgggaggccc aggtggctct gcagcagcct ctgccaccct gtgacctgcg    120

agtattggga catccctagc tgacgccagg acacccggga agccgaggaa tggactcggt    180

ggcttttgag gatgtggctg tgaactttac ccaggaggaa tgggctttgc tagattcttc    240

tcagaagaat ctctacagag aagtgatgca ggaaacctgc aggaacctgg cttctgtagg    300

aagccaatgg aaagaccaga atattgaaga tcacttcgaa aaacctggga aagatataag    360

aaatcatatc gtacagagac tgtgtgaaag taaagaagat ggtcagtatg gagaagttgt    420

cagccaaatt ccaaatcttg atctgaacga gaacatttct actggattaa aaccatgtga    480

atgcagt                                                              487


<210>  2205
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  2205

Met Asp Ser Val Ala Phe Glu Asp Val Ala Val Asn Phe Thr Gln Glu 
1               5                   10                  15


Glu Trp Ala Leu Leu Asp Ser Ser Gln Lys Asn Leu Tyr Arg Glu Val 
            20                  25                  30


Met Gln Glu Thr Cys Arg Asn Leu Ala Ser Val Gly Ser Gln Trp Lys 
        35                  40                  45


Asp Gln Asn Ile Glu Asp His Phe Glu Lys Pro Gly Lys Asp Ile Arg 
    50                  55                  60


Asn His Ile Val Gln Arg Leu Cys Glu Ser Lys Glu Asp Gly Gln Tyr 
65                  70                  75                  80


Gly Glu Val Val Ser Gln Ile Pro Asn Leu Asp Leu Asn Glu Asn Ile 
                85                  90                  95


Ser Thr Gly Leu Lys Pro Cys Glu Cys 
            100                 105


<210>  2206
<211>  584
<212>  DNA
<213>  Homo sapiens

<400>  2206
ggttgctttg tctctccttc gccggagccg gctcttcctg ttagtctccg ctgctagttc     60

ttggctctgg gaggcccagg tggctctgca gcagcctctg ccaccctgtg acctgcgagt    120

attgggacat ccctagctga cgccaggaca cccgggaagc cgaggaatgg tgagtggact    180

gcgcctggct tcccgaagtg gagaagaggg ctggttgaaa cctgctgtgg cgcgactcgg    240

gcctccacgc catcggctcc ggaacctgcg gaccgagtcg ccgtggcgta gccggggctc    300

agtcctcttc tgttcagggc cgggccgggc ggggcgggca gcggaacccc tgcatcctgt    360

ctgtacctgc gggcgccact tccgccggcc ggagccctgt cgggaacccc tcgcctcccc    420

tatccaggac tcggtggctt ttgaggatgt ggctgtgaac tttacccagg aggaatgggc    480

tttgctagat tcttctcaga agaatctcta cagagaagtg atgcaggaaa cctgcaggaa    540

cctggcttct gtagaaatca tatcgtacag agactgtgtg aaag                     584


<210>  2207
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  2207

Met Val Ser Gly Leu Arg Leu Ala Ser Arg Ser Gly Glu Glu Gly Trp 
1               5                   10                  15


Leu Lys Pro Ala Val Ala Arg Leu Gly Pro Pro Arg His Arg Leu Arg 
            20                  25                  30


Asn Leu Arg Thr Glu Ser Pro Trp Arg Ser Arg Gly Ser Val Leu Phe 
        35                  40                  45


Cys Ser Gly Pro Gly Arg Ala Gly Arg Ala Ala Glu Pro Leu His Pro 
    50                  55                  60


Val Cys Thr Cys Gly Arg His Phe Arg Arg Pro Glu Pro Cys Arg Glu 
65                  70                  75                  80


Pro Leu Ala Ser Pro Ile Gln Asp Ser Val Ala Phe Glu Asp Val Ala 
                85                  90                  95


Val Asn Phe Thr Gln Glu Glu Trp Ala Leu Leu Asp Ser Ser Gln Lys 
            100                 105                 110


Asn Leu Tyr Arg Glu Val Met Gln Glu Thr Cys Arg Asn Leu Ala Ser 
        115                 120                 125


Val Glu Ile Ile Ser Tyr Arg Asp Cys Val 
    130                 135


<210>  2208
<211>  2479
<212>  DNA
<213>  Homo sapiens

<400>  2208
tggatgaggt cagaatgacc gcttttggcc tagcggtttg taggcggtgc gtccttcctg     60

cgctgggatc cgaccatgca agaaggacat tcacatttaa cctgtataca agttatagct    120

atttgtgcct tttatatata tatatatata taaaattgga agcaatataa tgacagttct    180

gtaactgccc agggagttca ccttgcccgc tacctagaca gagccgattt ctcaagacag    240

gggaatagca atagagaaag agtaattcac gcagtgtcct ctgtgcggga gaccggagtt    300

tttttatttt attttatttt tttgaaacag aatcttgctc tgtctcccag gctggagtgc    360

aggcttggag ttttatgatt attcaaatca gtctccctga gcatttgggg taagagtatt    420

tagaacgttt attttgccaa ggttggggat gcatatgcat gacacagcct caggatgtcc    480

ttgatgacat gtgcccaagg tggtcagagc acagcttggt tttgttggag agaaatgctc    540

ggtgccgcaa agtgaaacca gcactcaagc gaaagttttc tcagcaacgc aatttacttc    600

tgcagaagcg tgctgctcgc atcaatcacg atcgcaagag cacactgaac agaggaaagc    660

aggggttttt attcctaacg cagtccctac ctctggcatg ggctggggtc agaccgcacg    720

atctaaactg acccggttgg ctatttgtga atattttccc aaataaggaa gggggaaggg    780

ggatgtgagt tacaatggtg ggacttgcgg tttccaaggg agaaatgggt gcagagcagg    840

taaccaaggg aacagatgtg agttattgat tagaactgac ggaaggttgt ttacagtaac    900

taagggcaag gaggcatgga gaacaagaaa gttgagttcg aaaacaaaaa aacaagaaag    960

ttaacatgcc aaaccttgga agagaaactg actgtatctg acagctttat acattttagg   1020

gaaacaggag acatcaatca acatatgtaa gatgaacact ggtttgatcc gggacaacct   1080

gaagcaaaag cgggtcaact cgaagccagg agggggcttc caggtcacag aaatggggtc   1140

tccctcagtt gcccaggctg gtctctggtg cccaacgccg ggctcccggt aatctctaca   1200

aataatccag tgaaggaatg ccagagagtg gaaagtggag gatgactgac aaaggacgcc   1260

cgagtacgtt ttcacttcaa gctctacagg agagaatcag cttcctgtct gggtacccac   1320

aagacatctt aagctgtgcc atgagacaga gtccaagaag aggaaaagac ctcagaatgt   1380

ctctgcgccc ccagttcgtc agacggctca gatgaacatc tctgttgagc agatggaaac   1440

cagtaaaact ccccaagcaa ctccaccgac ctgggggcag atgaagagac tggctcacat   1500

tgcagaagag aacctgaggt ctcagaacaa gccgctgacc accagtaatc taatggtagc   1560

tatgatggcg gtaatctcct tggtggtgag tcttcctgta gcagaggcag atcaaaatta   1620

cacctatttt tgtaatagga ggaaggagga ggaggaggaa tgttaatgaa tgtttctatt   1680

ggttatcgct ttcctgccat ctgcctgggg ccagcagcag gatttttaaa ttatgataca   1740

caaagttgga tggtttatgt tcctgcacat aacggatcaa aagcctttat tcatgcaatc   1800

agtggaagaa catttcaatc tttggacact attaaatacc ttgagcatgg ctatgttgtg   1860

acacatcgcc agattaataa atttaaacct aataagaacc tcctgttatt aaacggtcag   1920

aaaagctaga ggtgctaacc tgggaagatt atattgcaaa cagtgctgct gtactacaaa   1980

ataattccta tggaatcatc attgattggg cccctagggg acaatttgca gtaaattgta   2040

ctggacagag tgaagattgt agagagacta ttttgcaaac gactacccag ataatgcacc   2100

aaaattacat agaagaattg aaacaaatta ccctattaag tgggaggaga acggtatggc   2160

tcctccaagc ccaaaaatta ttgatccaat tataagccca gaacatccag aattgtggaa   2220

attaatgatg gctcaaagcc caattcggat ttggaaagca gaatgtaaaa cagagaccca   2280

tagtaaaaaa cttcgatttg ttgtagccat gacctctaat cagatggtcc cattgcagag   2340

ttgtgttaaa cctcctttta tgttggcagt gggaaaaatt aatatcttac ctgactctca   2400

aaccatatca tgcctcaact gtcgtctttt tacctgcatt atttctgcct ttaataaaga   2460

taatagcatt ttactggtt                                                2479


<210>  2209
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  2209

Met Pro Glu Ser Gly Lys Trp Arg Met Thr Asp Lys Gly Arg Pro Ser 
1               5                   10                  15


Thr Phe Ser Leu Gln Ala Leu Gln Glu Arg Ile Ser Phe Leu Ser Gly 
            20                  25                  30


Tyr Pro Gln Asp Ile Leu Ser Cys Ala Met Arg Gln Ser Pro Arg Arg 
        35                  40                  45


Gly Lys Asp Leu Arg Met Ser Leu Arg Pro Gln Phe Val Arg Arg Leu 
    50                  55                  60


Arg 
65


<210>  2210
<211>  509
<212>  DNA
<213>  Homo sapiens

<400>  2210
agaatgaccg cttttggcct agcggtttgt aggcggtgcg tccttcctgc gctgggatcc     60

gaccatgcaa gaaggacatt cacatttaac ctgtatacaa gttatagcta tttgtgcctt    120

ttatatatat atatatatat aaaattggaa gcaatataat gacagttctg taactgccca    180

gggagttcac cttgcccgct acctagacag agccgatttc tcaagacagg ggaatagcaa    240

tagagaaaga gtaattcacg cagtgtcctc tgtgcgggag accggagttt ttttatttta    300

ttttattttt ttgaaacaga atcttgctct gtctcccagg ctggagtgca ggcttggagt    360

tttatgatta ttcaaatcag tctccctgag catttggggg aaacaggaga catcaatcaa    420

catatgtaag atgaacactg gtttgatccg ggacaacctg aagcaaaagc gggtcaactc    480

gaagccagga gggggcttcc aggtcacag                                      509


<210>  2211
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  2211

Met Thr Ala Phe Gly Leu Ala Val Cys Arg Arg Cys Val Leu Pro Ala 
1               5                   10                  15


Leu Gly Ser Asp His Ala Arg Arg Thr Phe Thr Phe Asn Leu Tyr Thr 
            20                  25                  30


Ser Tyr Ser Tyr Leu Cys Leu Leu Tyr Ile Tyr Ile Tyr Ile Lys Leu 
        35                  40                  45


Glu Ala Ile 
    50


<210>  2212
<211>  10068
<212>  DNA
<213>  Homo sapiens

<400>  2212
atgcgcctgt cctccctgac tgaagaggct gtagatggag ggaatggagg cgagtggggt     60

gaggatctgt tagagcagtt cacatgcatt ccttcccgcg tggttgaagc taagactgct    120

ccagagtggc ctctgtgccc tggtgaaggc cagggtcttc atggcgagcc tctccctgac    180

cactgccagg gtaccggtgg ccaaattgac ccctccctgg ggaggggagg gagggccaag    240

cagcgtggct cccgagggag ttggtgggca gcaggggaga caatagcgaa catgctgtgt    300

gggctcagcc gggagacccc tggagaggcg gacgatgggc cctactccaa aggaggcaag    360

gacgcaggag gggccgacgt ttccctggcg tgccgcagac agagcattcc agaggagttc    420

cgagggatca ctgtggtgga gctgatcaag aaagaaggca gcacgctggg cctgactatc    480

tcaggtggca ccgacaagga tggaaagccc agggtctcca acctgagacc tgggggactt    540

gcagccagga gtgatctgct gaacattggt gactatattc ggtctgtgaa cgggatccac    600

ctgaccaggc tccgccacga tgagatcatc accctgctca agaatgtggg cgagcgcgtg    660

gtgctggagg tggagtatga gctgcccccg cccgctcctg agaataaccc caggatcatt    720

tcaaagacag tggacgtctc cctctacaag gagggcaata gctttggctt tgtccttaga    780

ggaggtgccc atgaagatgg gcacaagtcc cgcccgcttg tcctgaccta cgtgcggccc    840

ggtggccctg ccgacaggga gggctccctg aaggtgggcg acaggctgct cagtgtcgat    900

ggaatcccgc tgcacggggc cagccatgcc accgccctgg ccaccctgcg gcagtgcagc    960

cacgaggcac tctttcaggt ggagtatgat gtggccaccc ctgacacggt ggctaatgct   1020

tcgggaccct tgatggtgga aatagtcaag acgccagggt ctgccctggg gatctcgctc   1080

accaccacct ccctccggaa caagtcagtc attaccatcg accgcatcaa gccagccagc   1140

gtggtggaca ggagcggagc cctgcaccct ggagaccaca tcctgtccat cgatggcacc   1200

agcatggaac actgctcgct gcttgaggcc accaagctcc tggccagcat ttcagagaag   1260

gtgcggctgg agatcctgcc tgtgccccag agtcagcggc cactgaggcc tcagaggcag   1320

tgaaagtgca gaggagtgag cagctgcacc gctgggaccc ctgcgtgccc tcctgccaca   1380

gcccccggcc cggccactgc aggatgccca cctgggccac acctgctggc caggaccaaa   1440

gccgatcctt gtcttcaact cccttttcct cgccgacctt gaaccacgcc ttttcctgca   1500

acaaccccag cacccttccc cgtggatccc agcccatgag tcctcgaact acaatggggc   1560

ggaggaggca gcgaagaagg gaacacaaga gctcgttgtc gctagcctcc agcacggtgg   1620

ggccgggcgg gcagattgtg cacacggaga ccacggaggt cgtgctctgt ggagaccccc   1680

tcagcggctt tggcctccag ctccagggcg gcatcttcgc caccgagacc ctgtcctccc   1740

cacccctcgt gtgcttcatc gagcctgaca gtccggctga gaggtgtggg ctgctgcagg   1800

tgggggaccg tgtcctgtcc atcaatggca ttgccaccga ggacgggact atggaggaag   1860

ccaaccagct cctgcgggac gccgcactgg cccacaaggt cgtgctggag gtggagttcg   1920

atgtggcgga gtccgtcatc ccaagcagtg gcaccttcca cgtgaagctg cccaagaagc   1980

gcagcgtgga gctgggcatc accatcagct cggccagcag gaaacgaggg gagcccttga   2040

tcatctccga catcaagaaa ggcagcgtgg cacacaggac gggcaccctg gagccaggcg   2100

acaagctact ggccattgac aatatccgcc tggacaactg ccccatggag gacgccgtgc   2160

aaatcctgcg gcagtgcgag gacctggtga agctgaagat ccggaaggac gaggacaact   2220

ctgatgagct ggagaccaca ggtgccgtca gttacacagt ggagctgaag cgctacgggg   2280

gtcccctggg catcaccatt tcgggcacgg aggaaccttt tgaccccatt gtcatctcag   2340

gcctcaccaa gcgtggcctg gctgagagga ctggtgccat ccacgtgggg gaccgcattc   2400

tggccatcaa caacgttagc ctcaagggcc ggccgctgag cgaggccatc cacctcctgc   2460

aggtggctgg agagaccgtc acactgaaga tcaagaagca actagaccgt cccctcctac   2520

cccgcaagtc gggcagcctc agtgagacca gtgatgctga tgaggaccca gcagatgccc   2580

tgaaaggagg cctgccagca gcccgcttct cgccggctgt gcccagtgtg gacagtgctg   2640

tggagtcttg ggacagctcg gccaccgagg gtggctttgg gggcccaggg tcctatacac   2700

cacaggcagc agcccggggc acgacccccc aggagcggag gcctggctgg ctgaggggca   2760

gccccccacc caccgagccc cggaggacga gctatacccc aaccccagct gacgagagct   2820

ttccagagga ggaggaggag gatgattggg agccgccaac gagcccagcc cctggccctg   2880

cccgagagga gggcttctgg cgcatgtttg gagaagctct cgaagacctg gagtcatgtg   2940

gtcagtcaga gctgctgagg gaactggagg catccatcat gacgggcacc gtgcagaggg   3000

tggccctcga gggcaggcct ggccaccggc cttggcagag gggccgggag gtacgagcct   3060

ctcctgcaga aatggaggag ctgttgctgc ctacaccctt ggagatgcac aaggtgaccc   3120

tgcacaagga ccccatgcgg catgactttg gtttcagcgt ctcagatggc ctcctggaaa   3180

aaggtgtcta tgtccacact gtgcgccctg atgggccagc ccaccgtgga ggcctccagc   3240

ccttcgacag ggtcctgcag gtcaaccacg tccgtacacg ggacttcgac tgctgcctgg   3300

cggtgccact cctggccgag gcgggtgatg tcttggagct gatcatcagc cgcaagccgc   3360

acacggcaca cagcagccgg gccccccgat cgccaggccc cagcagtccc cggatgctct   3420

gaagtcagca tgtgggccga actcctaagg ggccacccag gcagatcctg gctcccagac   3480

acgtagctgg gctggagaag cggccaccca ctcattcatc tgttggtctg gcagactctg   3540

agcctgggat gatgcttggt ctctgttccc caggtctgtg gtgactgggg tgccaggcag   3600

ggaggtcctg ccctagttgg agtgacagct ggggtctctc gccaagttgg gtctccaaga   3660

tgcccagagg agcctccctt aagaagggtt ggcacaggct gctcagccga gaggagagag   3720

gcctgggggc tgtcccaggt ctctgtgggg cctccttgga gaggtcgaag atgtagggag   3780

cacttcctcc cagcaaagcc atggagctgg aatgagctgc aaggaggagt gagttctcgg   3840

tcacaggagg tgagcaggca ggagctggat accccagcgc agtcatgcat tggggtatga   3900

ggcattccca tgatgcgtgc acacgcgctt gggggttggc ttcctgatgg ggagccactt   3960

catctagaga ctcggccacc aggaaggatg ctgcttcgga tgggagccca gctccttcgc   4020

ttctccagaa taggggtttg gggcttgcta gtcctgagat tctgagattc ccagaatctg   4080

gtccccactt atgagactct taagttgggg cgtctgggat cccaggaagt gctggccctt   4140

tgattctgaa agtgggtgat tctttgattt cagcatctca gtctgaagct tctgggactt   4200

gagactgtgg ttctgggccc attgggcagg ctctatgggc cttgggctct cagccctcct   4260

gcttcttctg taggccgtgt ggccactgac ccatctgcac gtccgctcag cccaagcccc   4320

tccatgtggg aggggtcatt ttggggcaaa agaccctgga gcttccattc acctgccatc   4380

cagtgaaaat tgaaaagcga tggacgcagg acctgtgagg cggtagcgct cctctttaca   4440

gccagatcag tggaggaaga ggagaaagag ggagggagat gggagagaaa tgggccagag   4500

aaaaagatgg gacactcttg cccagtggag ggtgtccaaa gtgcttattc aaagaagtct   4560

attcccactt gaaatctgga agcaccagca tcccttaaaa tcattgtcct cagtgtccac   4620

aaatcagaga ccctcttcat tttgagaagg gtgtgggcct cccctggtgg tctagtgagt   4680

ggtgcctggg atggagtggg cgggcaggtg tagccagggc tggggatgtg ctttgcctgg   4740

cccagttctc acaggggtct caggaaaacg gggcacccac tcccacctcc atctgtctcc   4800

aacctggggt ccctggaggc cagaaaagtg ctcttccatt tgagggaaca gatgaggagt   4860

caagaggtct gttcttttca ccctgggtct gttacctgtt tgctgtgtga ccctgtctgg   4920

gttggacccc cagcccctct ggacgatcac gggtggacag tctgagcaga cacaggcctc   4980

ctggtcaggg ccggaaccat ctctgccgac ccaccaaggc ccccttgggg acctgcccac   5040

gctgtctcct ggaggcctgc ctcccttacc cctcccctcc acttcgctgg gctctgcccc   5100

ttggtgccct ccctgagggc cctgcatgct tgtgcctggg gtgctcagcg cctctgctat   5160

cttggattcc cgtgtactca gcccagagtg aaagggcact gtctacctgt cacagggcac   5220

caagtgaaag ccaagagccc tcacttttga gggtgaggga cagcacagca gaggtgtggc   5280

ttctggatgc aagcagccat agctgtgtga ccttggacag gtggctcagc ctctctggac   5340

ctctgctaag caacagggct ggacaggaca cactctcagg gcctctcggc ttgggaaaac   5400

tgcattgact ccaggactcc aggcgaggga agatgcaccc gactctaact aatacccccc   5460

tccctcctcg ggctgaggcc tctgccattc tcccaaaagt atgcaatcag gcccgcggtg   5520

ggcctcccag ccatgccggc ctcctcatat gcaatatttc ttctggcttc tcatggggat   5580

ggttcatccc cgacttgaaa tttcctgaca cctttcccca gtgagcgccc tgcctgccta   5640

tgcattttgg gaacagcccc tgtgacatgt ccccttccac ctgccctctc ccccaaagct   5700

gtatttttct ctggctgaga ttagaacaca ttccttgtaa agtatttttc tacatcgggt   5760

tttcttaggg ctctcgggaa gcacaagggg ctgtattgca aaggccgctt atggtctgtt   5820

tggggccctc gtctaagtct ttgtcccacc aggggttgca gtggcttggg ggtaggtgcc   5880

atggggatga ttttttaaaa taaaattatt taaatccacc tagagtagaa gtttgctttt   5940

taaaaaaatc atggattggc aagagtcagc ttctgtatgg gtctggtgac atctcacctg   6000

cttttgatga ttcattaatt caaaaagttt gccatttgct tccatcatcc agcccctggg   6060

caacatgaat cagacagatt taggtcatgt ctgcacattc tggtggcagg cagacaatca   6120

acaagtaagc aaataaataa ttatttcaaa aggcatcaag tgcaacaaag aaaacaaggg   6180

agtaacggga tagagggacc agggtgaggg gctttagctc acaatattag gaggggtttc   6240

tctcaagagg cgacatttgc aatgagacct gaagacagga gccagcctcc atggagacct   6300

ggaggaagag tgtctcaggc agcgggcaca gctagtgcaa aggccctgag ataggaacga   6360

gtttgacggt ctcaaggaag agaaagaagg cctgggaggg gaatggggct ggagactagg   6420

ttggaggtag caggaatcag tcgtgaaggc ttgggtaggg ggagcaaatt tgattctctg   6480

cgcagcagaa agccagaggc aggcagtggt gcctgcatat ggagtctctt tagcccaggt   6540

tgggaaggta gtggcaggag ggcagcctca ggtctggctg ctgccctgga gtgtccagag   6600

agtgtctagg gcaggtgagc tacagggtct gggacccaga ggccagggcc aggccccact   6660

ggggaggcca cagttctgtg agcagaggaa gagcttcttt ccaggaagcg agtactctgt   6720

cttgggagtg gtgtaggcag ggggaaggcc aagggaggca gcaggccttg ctctaagcgc   6780

tttgcaagag cttgctggat cctcccaata gcctttggag gtgggctcta ttcctgtccc   6840

atcattacag atgaggaaac aggcacagag aggttacgta atttgcccaa gtccacacag   6900

gtagtaaggg atggaaccag ggcttgaaca caagccacat ggcccagtac acatagagag   6960

aggcaggcag gtaggcatag gctgtcagaa agagccagaa aatgggggta gggtggtctt   7020

ctattctaac attgtctata aatgagttac tgagaatttt gtctggttag ttgggcaaag   7080

ggctcaactg actcccgagt ttgtccatcc caaagggtgg ggggcgctgt tggcaggaag   7140

gctgccccaa acatggacct gttgtgaccc cagagagccc ctaactgggt attaatgagc   7200

gcctgcacct gacggtgggg gagtgggaga agggcaatca ggtttgctcc ccctctaccc   7260

tttcccccac tccgccaccc gctttctgcc cttctggcag gtcagcccaa ggctaaagag   7320

gagggactga aagccgcagc aggtgagcac ctaaggccaa gagcatcacc tccaatcatc   7380

ctggtggcct tgatggggac aatggtttat tccagatggg gaaactgagg ctcaggtgac   7440

tgctgccaga tctcccagct gtacagggct gggcatgtag caggtagaat cagtagagcc   7500

agtagagcca agagctcatg ggcccgggtg cgaatccagg ttctttcatg gacttgctgt   7560

gtacccctga gtgagcaagc tgcttcctct gtgagcctcc atgtgggaac ctctaacctg   7620

ggaaaatacc tacctttgag gagcgtcctg ggattggacg ggaagccctt tataaaatgt   7680

aaagcgtttg gcaaacgttg agggggaaat acctcaccag aacacaaccc acacatgttg   7740

gatgttaaaa aggaaatgtt tattttcatg ttataaggtg attacaaact cctctaaaaa   7800

aagcaaagat gaatttaaaa tattgatata catatttatc taaaaagcaa aagagaaaaa   7860

aacccctgca aaatacaggg aatcatatca taaaacattt atacacaaaa gcttgtatac   7920

tgcaagactg aactacacac caaggatctt gttcaaatac aaatgttcct cctcagaaaa   7980

gtctcttgtt ggttgatttt ttttttataa aagtttaaaa tatcttaaaa atattttgaa   8040

gttttaaaaa aatgtcctga tgagccagac atatttctgg aaggaggcaa gacccacatt   8100

ctcagctttc tcttgtgcta aatacagagt cacagttgct agggattggg agattaattg   8160

ggtaaaaaaa aaaaatgaag ccaacatctc aatttgaagt caaatatata acaggatgct   8220

ccatccctcg gagaacacgc cagaacatgt ctgtagtgac acccacaaga gaacaatgca   8280

aaaatgcttc ctattacaac aatatatatt ctgaggatca gggagagaag gaaaggggga   8340

gggctgcccc ctgctttctg gactgcccac ctctacaagt ttggctctct gggtttgttt   8400

tgtttagtct tgtggttttg tacttcgatt tttgcacaca gtggtattta ccgtgtccca   8460

ggcagcctgg cctgggacca catgggtctg agggagggat gggacctcag gccaccttga   8520

aggattttct cttgggtcct ttcctggctt gtgtctgaat cttgggtggg gtgggctgcg   8580

gggagcagtt aggtgcctct gcctttagac tggctaccca gagcatttcc ccagggagag   8640

gggctgtgct gggagatgct ggctgggtgg gggaccagtg tggcggtacc cgggtgatac   8700

aagagtgccc tgaagtgggc tggaggggcc atgctgtgct ctccccttgt gtttccccac   8760

tgtctttggg ggtatgctgg ggatccaggg ggcagtgaag gagctgcaca tggcccaggg   8820

gttatgctgt cctggaagga gagcatccaa ggccacttcc tgctgcctgg aaactccccg   8880

cagagcctcg gggtcagtct ggagccaggg cgacttcatc taaatcctgc ctaaggatct   8940

ggcacacctc tggcttctct gcacctcagt tccctctttc acaaacaggg atctcaattc   9000

ctagctcacc aagggctgct gggaggaagg agggccccgt gcagggctgg ggtgtgcagg   9060

tgaggctgga gtcacccagc tcacggagcc accgcatggg tccaggaatt ctgtgaggat   9120

ggtgggagtg tggctgctgc tgctcccctc atccctgaac atggagggga gcgcatttcc   9180

ttttccataa aggcttgtct ttggttgtca ggaagacctt gaggatgttg ctggatgtag   9240

ccctggttag acactcacca ttccctgcac ctacctcgga gaacctgcag ctagagctgt   9300

ttcaagaaaa tccattcctg gctcacagtg cctccctgag cctcagttac ctcatttaca   9360

acaagggcgt tgggttaggg gaccctggag gcccttctct ccctgaccgt caggaaatct   9420

ctgtggccct agcatggccc atctcaacgc agtgtctccc acttcttcat cttaaaaaat   9480

tgatttaaac aaccccctcg cttcctttcc agatctggct ggctgggcta tgtgcgggca   9540

tcagcatttc tgacccatcc caagcagaaa gcaggtgaag gactttgccc attctctata   9600

gacaggtgga ccagagtcat gagctctcat ggaaagtttc gtttatacgg agacatgaag   9660

gttgagcatt attacacagg tactcgcaga gctatgctct gcacacagag ccagggctgg   9720

ctgggcgaga gggctctgat tggagacagg tgccttgggg agagttgagg aacgacttcc   9780

ttccaggcgg ggcctgggga cttggtctgc ctgtgtcttt ggtctagaat ttggtctgag   9840

aatcttataa gaagaggcct tcctcaggcc atgtccagaa tgttgcaatt tgcctaccaa   9900

cccaaaatac tgtggccttt cacccaggga gcccccgctg gggagatgga aactgaaatg   9960

accacaaatg cccaggtagc cactgcgtgc caagtcccct cttccccacg tgccacctgc  10020

cctcaatcat tgacagtggt tagtttacta aagttatata agacaaag               10068


<210>  2213
<211>  672
<212>  PRT
<213>  Homo sapiens

<400>  2213

Met Pro Thr Trp Ala Thr Pro Ala Gly Gln Asp Gln Ser Arg Ser Leu 
1               5                   10                  15


Ser Ser Thr Pro Phe Ser Ser Pro Thr Leu Asn His Ala Phe Ser Cys 
            20                  25                  30


Asn Asn Pro Ser Thr Leu Pro Arg Gly Ser Gln Pro Met Ser Pro Arg 
        35                  40                  45


Thr Thr Met Gly Arg Arg Arg Gln Arg Arg Arg Glu His Lys Ser Ser 
    50                  55                  60


Leu Ser Leu Ala Ser Ser Thr Val Gly Pro Gly Gly Gln Ile Val His 
65                  70                  75                  80


Thr Glu Thr Thr Glu Val Val Leu Cys Gly Asp Pro Leu Ser Gly Phe 
                85                  90                  95


Gly Leu Gln Leu Gln Gly Gly Ile Phe Ala Thr Glu Thr Leu Ser Ser 
            100                 105                 110


Pro Pro Leu Val Cys Phe Ile Glu Pro Asp Ser Pro Ala Glu Arg Cys 
        115                 120                 125


Gly Leu Leu Gln Val Gly Asp Arg Val Leu Ser Ile Asn Gly Ile Ala 
    130                 135                 140


Thr Glu Asp Gly Thr Met Glu Glu Ala Asn Gln Leu Leu Arg Asp Ala 
145                 150                 155                 160


Ala Leu Ala His Lys Val Val Leu Glu Val Glu Phe Asp Val Ala Glu 
                165                 170                 175


Ser Val Ile Pro Ser Ser Gly Thr Phe His Val Lys Leu Pro Lys Lys 
            180                 185                 190


Arg Ser Val Glu Leu Gly Ile Thr Ile Ser Ser Ala Ser Arg Lys Arg 
        195                 200                 205


Gly Glu Pro Leu Ile Ile Ser Asp Ile Lys Lys Gly Ser Val Ala His 
    210                 215                 220


Arg Thr Gly Thr Leu Glu Pro Gly Asp Lys Leu Leu Ala Ile Asp Asn 
225                 230                 235                 240


Ile Arg Leu Asp Asn Cys Pro Met Glu Asp Ala Val Gln Ile Leu Arg 
                245                 250                 255


Gln Cys Glu Asp Leu Val Lys Leu Lys Ile Arg Lys Asp Glu Asp Asn 
            260                 265                 270


Ser Asp Glu Leu Glu Thr Thr Gly Ala Val Ser Tyr Thr Val Glu Leu 
        275                 280                 285


Lys Arg Tyr Gly Gly Pro Leu Gly Ile Thr Ile Ser Gly Thr Glu Glu 
    290                 295                 300


Pro Phe Asp Pro Ile Val Ile Ser Gly Leu Thr Lys Arg Gly Leu Ala 
305                 310                 315                 320


Glu Arg Thr Gly Ala Ile His Val Gly Asp Arg Ile Leu Ala Ile Asn 
                325                 330                 335


Asn Val Ser Leu Lys Gly Arg Pro Leu Ser Glu Ala Ile His Leu Leu 
            340                 345                 350


Gln Val Ala Gly Glu Thr Val Thr Leu Lys Ile Lys Lys Gln Leu Asp 
        355                 360                 365


Arg Pro Leu Leu Pro Arg Lys Ser Gly Ser Leu Ser Glu Thr Ser Asp 
    370                 375                 380


Ala Asp Glu Asp Pro Ala Asp Ala Leu Lys Gly Gly Leu Pro Ala Ala 
385                 390                 395                 400


Arg Phe Ser Pro Ala Val Pro Ser Val Asp Ser Ala Val Glu Ser Trp 
                405                 410                 415


Asp Ser Ser Ala Thr Glu Gly Gly Phe Gly Gly Pro Gly Ser Tyr Thr 
            420                 425                 430


Pro Gln Ala Ala Ala Arg Gly Thr Thr Pro Gln Glu Arg Arg Pro Gly 
        435                 440                 445


Trp Leu Arg Gly Ser Pro Pro Pro Thr Glu Pro Arg Arg Thr Ser Tyr 
    450                 455                 460


Thr Pro Thr Pro Ala Asp Glu Ser Phe Pro Glu Glu Glu Glu Glu Asp 
465                 470                 475                 480


Asp Trp Glu Pro Pro Thr Ser Pro Ala Pro Gly Pro Ala Arg Glu Glu 
                485                 490                 495


Gly Phe Trp Arg Met Phe Gly Glu Ala Leu Glu Asp Leu Glu Ser Cys 
            500                 505                 510


Gly Gln Ser Glu Leu Leu Arg Glu Leu Glu Ala Ser Ile Met Thr Gly 
        515                 520                 525


Thr Val Gln Arg Val Ala Leu Glu Gly Arg Pro Gly His Arg Pro Trp 
    530                 535                 540


Gln Arg Gly Arg Glu Val Arg Ala Ser Pro Ala Glu Met Glu Glu Leu 
545                 550                 555                 560


Leu Leu Pro Thr Pro Leu Glu Met His Lys Val Thr Leu His Lys Asp 
                565                 570                 575


Pro Met Arg His Asp Phe Gly Phe Ser Val Ser Asp Gly Leu Leu Glu 
            580                 585                 590


Lys Gly Val Tyr Val His Thr Val Arg Pro Asp Gly Pro Ala His Arg 
        595                 600                 605


Gly Gly Leu Gln Pro Phe Asp Arg Val Leu Gln Val Asn His Val Arg 
    610                 615                 620


Thr Arg Asp Phe Asp Cys Cys Leu Ala Val Pro Leu Leu Ala Glu Ala 
625                 630                 635                 640


Gly Asp Val Leu Glu Leu Ile Ile Ser Arg Lys Pro His Thr Ala His 
                645                 650                 655


Ser Ser Arg Ala Pro Arg Ser Pro Gly Pro Ser Ser Pro Arg Met Leu 
            660                 665                 670


<210>  2214
<211>  4116
<212>  DNA
<213>  Homo sapiens

<400>  2214
caggaatgga aacgaaagtg gaactcggcc tttccctctt tctctcctgc agacgatggg     60

ccctactcca aaggaggcaa ggacgcagga ggggccgacg tttccctggc gtgccgcaga    120

cagagcattc cagaggagtt ccgagggatc actgtggtgg agctgatcaa gaaagaaggc    180

agcacgctgg gcctgactat ctcaggtggc accgacaagg atggaaagcc cagggtctcc    240

aacctgagac ctgggggact tgcagccagg agtgatctgc tgaacattgg tgactatatt    300

cggtctgtga acgggatcca cctgaccagg ctccgccacg atgagatcat caccctgctc    360

aagaatgtgg gcgagcgcgt ggtgctggag gtggagtatg agctgccccc gcccggtggg    420

tgcccttgga cggggaactt tctccactgc ctcggttgcg ggtggacacg gctacctccc    480

caccagggcc tgggtggcag ggatcatgcc agatggagtg ggtagaacct ggagactggc    540

cacaagcatc catacctcgc ctaggggctg tgcctacaac cgcagtatgc tgtcaccagg    600

aggtggtggg actctatagc caatgtcatt ttacatattt agtctccaga tgcttttcct    660

ttagcgggga gggttttgga agcattagct gaataagtcg ttccctgacc taccacgccc    720

acactccact gccctgcact aagtaacggt ggtgtagggt ttcacctagc ttgggatttt    780

caaagctggt ctaaagtctt gaagtttgag taactgtctg gaattcagcc ctggcctgag    840

cctaccagcc atggactcaa gcctgagttc tgccgtcgtc tctgtgagca tgggcaggcc    900

ctttcctctc tctcagtggt gggctaagtg ggattagggg agaggatccc tctaagcctc    960

acttgttcga cctgtaaaat gggcaagggt ttaccctccc tgtaatctct gtgactgatc   1020

acccagtcct cctggaatga gctttgggca catctaccgg cctggagatg cgactgaggg   1080

actcaaagga gtcctccatt tctccccagc tcctgagaat aaccccagga tcatttcaaa   1140

gacagtggac gtctccctct acaaggaggg caatagcttt ggctttgtcc ttagaggtca   1200

gtgaaagaat tgcccttggt attggggcag caagaaagag gctaatacta attccatgtg   1260

tgtgctgttt ggatttgaat gtaatttatg tgtatctcag ttctgacttt gaagaacaca   1320

ggaccgttaa ggtaagtatt cagtgggaaa atctgccaag caatgaagta ggcttggttg   1380

gggagagtga gaggagaaag ttgtaccgga aaatgatggt gaaagctgct accgagactg   1440

agaacaaagt ctggagcttc ctagagatca gggaaaaggg gaaataaggt gaggtcacag   1500

aagggaggca agccatttaa cagagagaag actttggtca tgttacccac cccttgcacc   1560

atctcttggg agggcgaatt tattgttggt gtctcataag agggtccatg gatagcaagg   1620

acaaggtcct caaacaggtt ttattgaagg agcctgctca ggggctgtgt gggagcctct   1680

ggatgggaag gggtgggtgg atgattcctg cttcttgtca aatcctgtcc aggaggtgcc   1740

catgaagatg ggcacaagtc ccgcccgctt gtcctgacct acgtgcggcc cggtggccct   1800

gccgacaggt gagccgaggc agaagaaatc cacacactgc actgacctgc cccaactccc   1860

ctgcgaagaa ggtggagtgg ggtcaccatg ccccttcccc agatgaagag atcgaggccc   1920

tgagggaaca ctccctgccc ggtgtcattc agggagttgt tgatggaacc gggatgtaac   1980

cccaaatgag ggaaacctcg agccctttct tccccaacat actgctgtct caggggttgg   2040

ggtgtttgga gaggggcagc cttggtgtcg ttcttccctt tcctgctcct tggttttccc   2100

gtctgtggaa tggtccctaa gagttgctat gagagatttg ggggcacgct gattggccac   2160

tgctgtagcc gtctgtgact cagtctcctg ggtcctggct gatcgaccca gctcggcccc   2220

gcctgggccc agcccagaag ggccaggagg agagaatgtg gggaaagaac atgtccagtt   2280

cccagcccct gatccctcgg cctccccagt gggagattcc tggccatttt aagagaagcc   2340

tggaacggcc ttgtcagaaa tctaaatctg tccttgggac agggccctgt gatgagctat   2400

tcatagaacc cccgagaata gctttggcca cctgttggga gaggcgttcc aggctgggga   2460

tgcgacccaa accgaggtga accctgctgg ggcccctccc ctggcccctg ttgagttctt   2520

tcccaggcgc gggttgtcat caggccagaa tcaccgctga gaaaccaggg tgagggtgga   2580

gcaatgggaa gggaccagga cggctcagag cagcccccaa tgccgtgtgg catgggcaca   2640

gcttgcaccc tctctgggcc ctggtgctgt cctttgtccc tgaggcagga gttgggggtg   2700

acgcttgaag agcaccccca gctcagacat ttcagggttc tgcactgagt ctgtgaatta   2760

ctgcacaccc agaggagtgg caggcggcag agccacccca tcctgtcttc atccccccct   2820

tgctttatgc agctccccac tcctggagtg gctcattcct tcactcactc atgcgcccct   2880

tcacccgtcc cctcctcccc ttcctccccc acccattccc tgcttcttca tcctccatgt   2940

cccgcttccc agcgccctcc cagacaggct gtgcccagtg ctgctgccgg gccaggctgg   3000

tgactggccc ttccctacag ggagggctcc ctgaaggtgg gcgacaggct gctcagtgtc   3060

gatggaatcc cgctgcacgg ggccagccat gccaccgccc tggccaccct gcggcagtgc   3120

agccacgagg cactctttca ggtggagtat gatgtggcca cccctggtga gttgggggcc   3180

tgagtgtgtg ggttggggca ggaggaggcc tgggatgggg ggaggtggca gtggccatgg   3240

atctttacca ctgcaaaggc tgcatgacct tatgaccttg ggccagtcac agcttctctg   3300

ggcagtaaat agtatgtgct aggcattgtt tgatgtgctg gggatccagc ctagaacaac   3360

agaattgagg tgtctgttct catggagctg gcattctggt ggagagagga cagtatccag   3420

aatagataag atatggtgta tgtcagttgg caataagtgc tatggaaaaa agaaaagagg   3480

caggggagag agatgggaca ggctggggga tgctctctca ctaggggagt gagggaatga   3540

gcgaggcatg gaatgtccag ggacagcatt ccaggagggc ggaagagtaa gtgcaaaggc   3600

cctgaggcag gagcatggcc agcatggttg gtcacagtga ggaggctgcc gtggttggca   3660

caggtgagtg aaaggaggta agggcagagc agggtgaggt ggaagccggg aggccatagg   3720

aagcggcagc agctgtccaa gcgagagcta agggactgaa ccaggctggt ggctaaggag   3780

gggagaaggc acgggattca ggaaatatga tgacggtcca gctggcctga tctgctgaga   3840

tttagacatg ggtgggcgag ggcaggagct aagggtgcgg ccaaagtttt aatttccagc   3900

cactgggtgt gttaatggag gtgccatttc ctgagatggg gatgggttgt agtgaacttt   3960

acagtttagt gctggtatac cacaggctct tcataaactc aagcaaattc atttcaccca   4020

gcaaagccct gggatcacag cccctcagac ctgagctcct gcccctcctc cactgctatc   4080

ttatctgtca aattgatata acatttggta gaagat                             4116


<210>  2215
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  2215

Met Glu Thr Lys Val Glu Leu Gly Leu Ser Leu Phe Leu Ser Cys Arg 
1               5                   10                  15


Arg Trp Ala Leu Leu Gln Arg Arg Gln Gly Arg Arg Arg Gly Arg Arg 
            20                  25                  30


Phe Pro Gly Val Pro Gln Thr Glu His Ser Arg Gly Val Pro Arg Asp 
        35                  40                  45


His Cys Gly Gly Ala Asp Gln Glu Arg Arg Gln His Ala Gly Pro Asp 
    50                  55                  60


Tyr Leu Arg Trp His Arg Gln Gly Trp Lys Ala Gln Gly Leu Gln Pro 
65                  70                  75                  80


Glu Thr Trp Gly Thr Cys Ser Gln Glu 
                85


<210>  2216
<211>  3445
<212>  DNA
<213>  Homo sapiens

<400>  2216
ggagttggtg ggcagcaggg gagacaatag cgaacatgct gtgtgggctc agccgggaga     60

cccctggaga ggcggacgat gggccctact ccaaaggagg caaggacgca ggaggggccg    120

acgtttccct ggcgtgccgc agacagagca ttccagagga gttccgaggg atcactgtgg    180

tggagctgat caagaaagaa ggcagcacgc tgggcctgac tatctcaggt ggcaccgaca    240

aggatggaaa gcccagggtc tccaacctga gacctggggg acttgcagcc aggagtgatc    300

tgctgaacat tggtgactat attcggtctg tgaacgggat ccacctgacc aggctccgcc    360

acgatgagat catcaccctg ctcaagaatg tgggcgagcg cgtggtgctg gaggtggagt    420

atgagctgcc cccgcccgct cctgagaata accccaggat catttcaaag acagtggacg    480

tctccctcta caaggagggc aatagctttg gctttgtcct tagaggtcag tgaaagaatt    540

gcccttggta ttggggcagc aagaaagagg ctaatactaa ttccatgtgt gtgctgtttg    600

gatttgaatg taatttatgt gtatctcagt tctgactttg aagaacacag gaccgttaag    660

gtaagtattc agtgggaaaa tctgccaagc aatgaagtag gcttggttgg ggagagtgag    720

aggagaaagt tgtaccggaa aatgatggtg aaagctgcta ccgagactga gaacaaagtc    780

tggagcttcc tagagatcag ggaaaagggg aaataaggtg aggtcacaga agggaggcaa    840

gccatttaac agagagaaga ctttggtcat gttacccacc ccttgcacca tctcttggga    900

gggcgaattt attgttggtg tctcataaga gggtccatgg atagcaagga caaggtcctc    960

aaacaggttt tattgaagga gcctgctcag gggctgtgtg ggagcctctg gatgggaagg   1020

ggtgggtgga tgattcctgc ttcttgtcaa atcctgtcca ggaggtgccc atgaagatgg   1080

gcacaagtcc cgcccgcttg tcctgaccta cgtgcggccc ggtggccctg ccgacaggtg   1140

agccgaggca gaagaaatcc acacactgca ctgacctgcc ccaactcccc tgcgaagaag   1200

gtggagtggg gtcaccatgc cccttcccca gatgaagaga tcgaggccct gagggaacac   1260

tccctgcccg gtgtcattca gggagttgtt gatggaaccg ggatgtaacc ccaaatgagg   1320

gaaacctcga gccctttctt ccccaacata ctgctgtctc aggggttggg gtgtttggag   1380

aggggcagcc ttggtgtcgt tcttcccttt cctgctcctt ggttttcccg tctgtggaat   1440

ggtccctaag agttgctatg agagatttgg gggcacgctg attggccact gctgtagccg   1500

tctgtgactc agtctcctgg gtcctggctg atcgacccag ctcggccccg cctgggccca   1560

gcccagaagg gccaggagga gagaatgtgg ggaaagaaca tgtccagttc ccagcccctg   1620

atccctcggc ctccccagtg ggagattcct ggccatttta agagaagcct ggaacggcct   1680

tgtcagaaat ctaaatctgt ccttgggaca gggccctgtg atgagctatt catagaaccc   1740

ccgagaatag ctttggccac ctgttgggag aggcgttcca ggctggggat gcgacccaaa   1800

ccgaggtgaa ccctgctggg gcccctcccc tggcccctgt tgagttcttt cccaggcgcg   1860

ggttgtcatc aggccagaat caccgctgag aaaccagggt gagggtggag caatgggaag   1920

ggaccaggac ggctcagagc agcccccaat gccgtgtggc atgggcacag cttgcaccct   1980

ctctgggccc tggtgctgtc ctttgtccct gaggcaggag ttgggggtga cgcttgaaga   2040

gcacccccag ctcagacatt tcagggttct gcactgagtc tgtgaattac tgcacaccca   2100

gaggagtggc aggcggcaga gccaccccat cctgtcttca tccccccctt gctttatgca   2160

gctccccact cctggagtgg ctcattcctt cactcactca tgcgcccctt cacccgtccc   2220

ctcctcccct tcctccccca cccattccct gcttcttcat cctccatgtc ccgcttccca   2280

gcgccctccc agacaggctg tgcccagtgc tgctgccggg ccaggctggt gactggccct   2340

tccctacagg gagggctccc tgaaggtggg cgacaggctg ctcagtgtcg atggaatccc   2400

gctgcacggg gccagccatg ccaccgccct ggccaccctg cggcagtgca gccacgaggc   2460

actctttcag gtggagtatg atgtggccac ccctggtgag ttgggggcct gagtgtgtgg   2520

gttggggcag gaggaggcct gggatggggg gaggtggcag tggccatgga tctttaccac   2580

tgcaaaggct gcatgacctt atgaccttgg gccagtcaca gcttctctgg gcagtaaata   2640

gtatgtgcta ggcattgttt gatgtgctgg ggatccagcc tagaacaaca gaattgaggt   2700

gtctgttctc atggagctgg cattctggtg gagagaggac agtatccaga atagataaga   2760

tatggtgtat gtcagttggc aataagtgct atggaaaaaa gaaaagaggc aggggagaga   2820

gatgggacag gctgggggat gctctctcac taggggagtg agggaatgag cgaggcatgg   2880

aatgtccagg gacagcattc caggagggcg gaagagtaag tgcaaaggcc ctgaggcagg   2940

agcatggcca gcatggttgg tcacagtgag gaggctgccg tggttggcac aggtgagtga   3000

aaggaggtaa gggcagagca gggtgaggtg gaagccggga ggccatagga agcggcagca   3060

gctgtccaag cgagagctaa gggactgaac caggctggtg gctaaggagg ggagaaggca   3120

cgggattcag gaaatatgat gacggtccag ctggcctgat ctgctgagat ttagacatgg   3180

gtgggcgagg gcaggagcta agggtgcggc caaagtttta atttccagcc actgggtgtg   3240

ttaatggagg tgccatttcc tgagatgggg atgggttgta gtgaacttta cagtttagtg   3300

ctggtatacc acaggctctt cataaactca agcaaattca tttcacccag caaagccctg   3360

ggatcacagc ccctcagacc tgagctcctg cccctcctcc actgctatct tatctgtcaa   3420

attgatataa catttggtag aagat                                         3445


<210>  2217
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  2217

Met Leu Cys Gly Leu Ser Arg Glu Thr Pro Gly Glu Ala Asp Asp Gly 
1               5                   10                  15


Pro Tyr Ser Lys Gly Gly Lys Asp Ala Gly Gly Ala Asp Val Ser Leu 
            20                  25                  30


Ala Cys Arg Arg Gln Ser Ile Pro Glu Glu Phe Arg Gly Ile Thr Val 
        35                  40                  45


Val Glu Leu Ile Lys Lys Glu Gly Ser Thr Leu Gly Leu Thr Ile Ser 
    50                  55                  60


Gly Gly Thr Asp Lys Asp Gly Lys Pro Arg Val Ser Asn Leu Arg Pro 
65                  70                  75                  80


Gly Gly Leu Ala Ala Arg Ser Asp Leu Leu Asn Ile Gly Asp Tyr Ile 
                85                  90                  95


Arg Ser Val Asn Gly Ile His Leu Thr Arg Leu Arg His Asp Glu Ile 
            100                 105                 110


Ile Thr Leu Leu Lys Asn Val Gly Glu Arg Val Val Leu Glu Val Glu 
        115                 120                 125


Tyr Glu Leu Pro Pro Pro Ala Pro Glu Asn Asn Pro Arg Ile Ile Ser 
    130                 135                 140


Lys Thr Val Asp Val Ser Leu Tyr Lys Glu Gly Asn Ser Phe Gly Phe 
145                 150                 155                 160


Val Leu Arg Gly Gln 
                165


<210>  2218
<211>  544
<212>  DNA
<213>  Homo sapiens

<400>  2218
cgaaagtgga actcggcctt tccctctttc tctcctgcag acgatgggcc ctactccaaa     60

ggaggcaagg acgcaggagg ggccgacgtt tccctggcgt gccgcagaca gagcattcca    120

gaggagttcc gagggatcac tgtggtggag ctgatcaaga aagaaggcag cacgctgggc    180

ctgactatct caggtggcac cgacaaggat ggaaagccca gggtctccaa cctgagacct    240

gggggacttg cagccaggag tgatctgctg aacattggtg actatattcg gtctgtgaac    300

gggatccacc tgaccaggct ccgccacgat gagatcatca ccctgctcaa gaatgtgggc    360

gagcgcgtgg tgctggaggt ggagtatgag ctgcccccgc ccgctcctga gaataacccc    420

aggatcattt caaagacagt ggacgtctcc ctctacaagg agggcaatag ctttggcttt    480

gtccttagag gaggtgccca tgaagatggg cacaagtccc gcccgcttgt cctgacctac    540

gtgc                                                                 544


<210>  2219
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  2219

Met Arg Ser Ser Pro Cys Ser Arg Met Trp Ala Ser Ala Trp Cys Trp 
1               5                   10                  15


Arg Trp Ser Met Ser Cys Pro Arg Pro Leu Leu Arg Ile Thr Pro Gly 
            20                  25                  30


Ser Phe Gln Arg Gln Trp Thr Ser Pro Ser Thr Arg Arg Ala Ile Ala 
        35                  40                  45


Leu Ala Leu Ser Leu Glu Glu Val Pro Met Lys Met Gly Thr Ser Pro 
    50                  55                  60


Ala Arg Leu Ser 
65


<210>  2220
<211>  545
<212>  DNA
<213>  Homo sapiens

<400>  2220
ggaagagctt caaggccaca tcgcagaggg actccgacac agggagaccc aaagaaaagg     60

catcagctac ttaaacattt ttagcagttc acagatttct tcactttctc tctggagggg    120

cagtggagag cgcacggctt ctgaggcagc ggcctgggat gaacctctag caattccgct    180

caccagcagt gtcacctcag ataagctact taaggtctct gggcttcagt tttgtcactt    240

gtcaaggagg aagtcctcct ccccctgtgt catgaagatt caaggagaga cacatggact    300

caccctgaac aacatggaca ctgagcaaaa cctcaattta tggttttaaa gatgtcaaga    360

agtattacct taatatacat gtcacaaaaa tccttgtcag actctgttct gatttacttg    420

ctatgtaggt cacatagcaa gtaaatgcct aaaaagtgca atttaatgat cctttcgtaa    480

actcctcttc ccctgggctg gaatgatgtt ctggagttat aaattaaaag aatgctggta    540

cccta                                                                545


<210>  2221
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  2221

Met Val Leu Lys Met Ser Arg Ser Ile Thr Leu Ile Tyr Met Ser Gln 
1               5                   10                  15


Lys Ser Leu Ser Asp Ser Val Leu Ile Tyr Leu Leu Cys Arg Ser His 
            20                  25                  30


Ser Lys 



<210>  2222
<211>  444
<212>  DNA
<213>  Homo sapiens

<400>  2222
tgagaattta gcttcctctg cacgatgcct gtcagggtcc ttggttgtca tctccatctt     60

agcgatgcag tcttttaggt gctttaaata aagggggaga gaggaaatct tctgaagcag    120

atgacaatta tttcccccaa gcacagccac caagccatgc tcttattttg aatgatctgc    180

gtcattttcc aacatgaagc ctcagaagga catgattaca ggctggactc accgactgta    240

gcctgtgcag ctattgtaat gttttaatca gtgattaagt caagaggttt aatttagtac    300

cgggctccgt taagcttgtg aaaatggttt tctgcctcct caaactaaaa atgtgtctct    360

cccccatgtg tccagcccga agcatcttaa cctttgttct atcttcaaca ccgctggctc    420

taacaaatta ctcagcagtg aatg                                           444


<210>  2223
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  2223

Met Val Phe Cys Leu Leu Lys Leu Lys Met Cys Leu Ser Pro Met Cys 
1               5                   10                  15


Pro Ala Arg Ser Ile Leu Thr Phe Val Leu Ser Ser Thr Pro Leu Ala 
            20                  25                  30


Leu Thr Asn Tyr Ser Ala Val 
        35


<210>  2224
<211>  1502
<212>  DNA
<213>  Homo sapiens

<400>  2224
gaagacactt ccggttgcga cggaggtagg cttacgaggc ctgtgtcggg tagaaagggt     60

ccttcctgga ccgggaccct ctgccacgac catggaccgt aggaaaaagc ctttggacgt    120

cacggcctcc tcgttggtag atcttaaggc tgaactcttc cgaaagcaag aagaattcaa    180

acaagaaaaa cttctaaaag attctggagt ttttggaaaa ccaaaaacaa ctaacaagaa    240

accaagtatc tggagcaaac agaatgtagg cgtttcaaat cgagctgaga aggatgctga    300

acagaagatt gaagaacaga agactttaga caaagcaagg gaaaaattgg aagaaaaagc    360

caaattatat gaaaaaatga ctaaaggaga ctttatagat gaagaagtag aggatatgta    420

ccttgtggat ttcacacaga agatcataga caagcgcaaa gaaatggagg catctggtgc    480

ccatagagat tctcaaaagg caggagaaag ggacgacgat gaggaaaacc ttcctgaggg    540

agagatccct cctccccaag accccagtga agaatgggtg gattacgtgg actctttggg    600

gcgttcccgg cgctgtatga gaaaggattt gccagatctg ctggagatgg ataaaaatct    660

tcaggggaga ctgtaagtgt gtgtggtata cagagctctg ccaaggtctg aaatgcagcc    720

acagggattg ttttgtgagg ggaggctgtt ttataattaa tgatctctgt tgctccagta    780

aggagatatt gattgattga ttgattgatt gaagcacttt ttagtggtta gcatgcacat    840

acacacataa tccacacttg gggaacaacc tgactggtgg atgagtagag ctgtctcttt    900

tacttggaag gatgtctgac aacagagtaa cagaataaac ccaaacgaaa ccagcaaacc    960

aggctttgtg gagacaagtg gtttgagaat atacacttga ttatcccaca aacaagtggc   1020

tctagggaga gaacttactc actttttctt tatgtatcat tgcatttttg aagtaagggc   1080

cttataacta gatttttcag cagggcctaa gacctaagac ataactctaa aacgtaagac   1140

ctaagagata actctgaaac atccagggga ataaattcct cttaccatag gaacttttat   1200

gtgaaaagtg ttgggagaaa ctccaccttg tccaagtcct gcaggttcag gcatccagca   1260

catagccttt ggcttggcat aagaaaggga gaatggaggc tgggcgcggt ggctcacgcc   1320

tgtaatccca gcactttggg aggccgaggc gggcggatca caaggttagg agttcgagat   1380

catcctggct agcacagtaa aaccccgtct ctactgaaaa tacaaaaaaa aaaaaaatta   1440

gccaggtgtg gttgcggccg cctgtagtcc cagctactca ggaggctgag gcaggagaat   1500

gg                                                                  1502


<210>  2225
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  2225

Met Asp Arg Arg Lys Lys Pro Leu Asp Val Thr Ala Ser Ser Leu Val 
1               5                   10                  15


Asp Leu Lys Ala Glu Leu Phe Arg Lys Gln Glu Glu Phe Lys Gln Glu 
            20                  25                  30


Lys Leu Leu Lys Asp Ser Gly Val Phe Gly Lys Pro Lys Thr Thr Asn 
        35                  40                  45


Lys Lys Pro Ser Ile Trp Ser Lys Gln Asn Val Gly Val Ser Asn Arg 
    50                  55                  60


Ala Glu Lys Asp Ala Glu Gln Lys Ile Glu Glu Gln Lys Thr Leu Asp 
65                  70                  75                  80


Lys Ala Arg Glu Lys Leu Glu Glu Lys Ala Lys Leu Tyr Glu Lys Met 
                85                  90                  95


Thr Lys Gly Asp Phe Ile Asp Glu Glu Val Glu Asp Met Tyr Leu Val 
            100                 105                 110


Asp Phe Thr Gln Lys Ile Ile Asp Lys Arg Lys Glu Met Glu Ala Ser 
        115                 120                 125


Gly Ala His Arg Asp Ser Gln Lys Ala Gly Glu Arg Asp Asp Asp Glu 
    130                 135                 140


Glu Asn Leu Pro Glu Gly Glu Ile Pro Pro Pro Gln Asp Pro Ser Glu 
145                 150                 155                 160


Glu Trp Val Asp Tyr Val Asp Ser Leu Gly Arg Ser Arg Arg Cys Met 
                165                 170                 175


Arg Lys Asp Leu Pro Asp Leu Leu Glu Met Asp Lys Asn Leu Gln Gly 
            180                 185                 190


Arg Leu 



<210>  2226
<211>  1506
<212>  DNA
<213>  Homo sapiens

<400>  2226
gaagacactt ccggttgcga cggaggtagg cttacgaggc ctgtgtcggg tagaaagggt     60

ccttcctgga ccgggaccct ctgccacgac catggaccgt aggaaaaagc ctttggacgt    120

cacggcctcc tcgttggtag atcttaaggc tgaactcttc cgaaagcaag aagaattcaa    180

acaagaaaaa cttctaaaag attctggagt ttttggaaaa ccaaaaacaa ctaacaagaa    240

accaagtatc tggagcaaac agaatgtagg cgtttcaaat cgagctgaga aggatgctga    300

acagaagatt gaagaacaga agactttaga caaagcaagg gaaaaattgg aagaaaaagc    360

caaattatat gaaaaaatga ctaaaggaga ctttatagat gaagaagtag aggatatgta    420

ccttgtggat ttcacacaga agatcataga caagcgcaaa gaaatggagg catctggtgc    480

ccatagagat tctcaaaagg caggagaaag ggacgacgat gaggaaaacc ttcctgaggg    540

agagatccct cctccccaag accccagtga agaatgggtg gattacgtgg actctttggg    600

gcgttcccgg cgctgtatga gaaaggattt gccagatctg ctggagatgg ataaaaatct    660

tcaggggaga ctttttatta gtcctgctaa tgaaaaaacc ctattatctg aagatatgag    720

aaaagaactt cagcgccagc aatgggagga agaagaaaga gaggccctga agaggcccat    780

ggggcccgta cattatgaag acattcggga aaatgaggcc cggcaacttg gtgttgggta    840

ttttgccttt gcccgagaca aagagttgag aaacaagcag atgaaaacct tagagatgct    900

gcgtgaacag acaacagatc agagaacaaa acgagaaaac ataaaggaaa agcgaaaggc    960

tatcttagag gcaagacttg ccaaacttcg acaaaaaaag atgaaaaaat caaaagaagg   1020

tggaacagaa gaagaaaata gagatggaga tgttattggg cctttgccac cggagccaga   1080

ggctgtgcca accccacgtc ctgctgccca gagtagcaaa gtagaagtca ttgtccagga   1140

gaggaaggac accaagcctg gagtgccaca catccgggag tgggaccgcg gaaaagaatt   1200

ttcctttgga tactggtcga agaggcagtc agatctccgg gctgagagag atcctgagtt   1260

tgccccgccg tcagattact ttgtgggtca gaagagaact ggtttttcca gcagccaggc   1320

atggagcaga cctgggccag cacagagtga cccagggcag tgccctgacc agagccacgg   1380

acctagccct gaacatacgt cacccactcc tgcccccgac aacccaccac aagcccccac   1440

agttactttc aaaactctgg atgacatgat ttcctattac aaacaagtga catgatcttt   1500

caaagc                                                              1506


<210>  2227
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  2227

Met Asp Arg Arg Lys Lys Pro Leu Asp Val Thr Ala Ser Ser Leu Val 
1               5                   10                  15


Asp Leu Lys Ala Glu Leu Phe Arg Lys Gln Glu Glu Phe Lys Gln Glu 
            20                  25                  30


Lys Leu Leu Lys Asp Ser Gly Val Phe Gly Lys Pro Lys Thr Thr Asn 
        35                  40                  45


Lys Lys Pro Ser Ile Trp Ser Lys Gln Asn Val Gly Val Ser Asn Arg 
    50                  55                  60


Ala Glu Lys Asp Ala Glu Gln Lys Ile Glu Glu Gln Lys Thr Leu Asp 
65                  70                  75                  80


Lys Ala Arg Glu Lys Leu Glu Glu Lys Ala Lys Leu Tyr Glu Lys Met 
                85                  90                  95


Thr Lys Gly Asp Phe Ile Asp Glu Glu Val Glu Asp Met Tyr Leu Val 
            100                 105                 110


Asp Phe Thr Gln Lys Ile Ile Asp Lys Arg Lys Glu Met Glu Ala Ser 
        115                 120                 125


Gly Ala His Arg Asp Ser Gln Lys Ala Gly Glu Arg Asp Asp Asp Glu 
    130                 135                 140


Glu Asn Leu Pro Glu Gly Glu Ile Pro Pro Pro Gln Asp Pro Ser Glu 
145                 150                 155                 160


Glu Trp Val Asp Tyr Val Asp Ser Leu Gly Arg Ser Arg Arg Cys Met 
                165                 170                 175


Arg Lys Asp Leu Pro Asp Leu Leu Glu Met Asp Lys Asn Leu Gln Gly 
            180                 185                 190


Arg Leu Phe Ile Ser Pro Ala Asn Glu Lys Thr Leu Leu Ser Glu Asp 
        195                 200                 205


Met Arg Lys Glu Leu Gln Arg Gln Gln Trp Glu Glu Glu Glu Arg Glu 
    210                 215                 220


Ala Leu Lys Arg Pro Met Gly Pro Val His Tyr Glu Asp Ile Arg Glu 
225                 230                 235                 240


Asn Glu Ala Arg Gln Leu Gly Val Gly Tyr Phe Ala Phe Ala Arg Asp 
                245                 250                 255


Lys Glu Leu Arg Asn Lys Gln Met Lys Thr Leu Glu Met Leu Arg Glu 
            260                 265                 270


Gln Thr Thr Asp Gln Arg Thr Lys Arg Glu Asn Ile Lys Glu Lys Arg 
        275                 280                 285


Lys Ala Ile Leu Glu Ala Arg Leu Ala Lys Leu Arg Gln Lys Lys Met 
    290                 295                 300


Lys Lys Ser Lys Glu Gly Gly Thr Glu Glu Glu Asn Arg Asp Gly Asp 
305                 310                 315                 320


Val Ile Gly Pro Leu Pro Pro Glu Pro Glu Ala Val Pro Thr Pro Arg 
                325                 330                 335


Pro Ala Ala Gln Ser Ser Lys Val Glu Val Ile Val Gln Glu Arg Lys 
            340                 345                 350


Asp Thr Lys Pro Gly Val Pro His Ile Arg Glu Trp Asp Arg Gly Lys 
        355                 360                 365


Glu Phe Ser Phe Gly Tyr Trp Ser Lys Arg Gln Ser Asp Leu Arg Ala 
    370                 375                 380


Glu Arg Asp Pro Glu Phe Ala Pro Pro Ser Asp Tyr Phe Val Gly Gln 
385                 390                 395                 400


Lys Arg Thr Gly Phe Ser Ser Ser Gln Ala Trp Ser Arg Pro Gly Pro 
                405                 410                 415


Ala Gln Ser Asp Pro Gly Gln Cys Pro Asp Gln Ser His Gly Pro Ser 
            420                 425                 430


Pro Glu His Thr Ser Pro Thr Pro Ala Pro Asp Asn Pro Pro Gln Ala 
        435                 440                 445


Pro Thr Val Thr Phe Lys Thr Leu Asp Asp Met Ile Ser Tyr Tyr Lys 
    450                 455                 460


Gln Val Thr 
465


<210>  2228
<211>  2730
<212>  DNA
<213>  Homo sapiens

<400>  2228
gaagacactt ccggttgcga cggaggtagg cttacgaggc ctgtgtcggg tagaaagggt     60

ccttcctgga ccgggaccct ctgccacgac catggaccgt aggaaaaagc ctttggacgt    120

cacggcctcc tcgttggtag atcttaaggc tgaactcttc cgaaagcaag aagaattcaa    180

acaagaaaaa cttctaaaag attctggagt ttttggaaaa ccaaaaacaa ctaacaagaa    240

accaagtatc tggagcaaac agaatgtagg cgtttcaaat cgagctgaga aggatgctga    300

acagaagatt gaagaacaga agactttaga caaagcaagg gaaaaattgg aagaaaaagc    360

caaattatat gaaaaaatga ctaaaggaga ctttatagat gaagaagtag aggatatgta    420

ccttgtggat ttcacacaga agatcataga caagcgcaaa gaaatggagg catctggtgc    480

ccatagagat tctcaaaagg caggagaaag ggacgacgat gaggaaaacc ttcctgaggg    540

agagatccct cctccccaag accccagtga agaatgggtg gattacgtgg actctttggg    600

gcgttcccgg cgctgtatga gaaaggattt gccagatctg ctggagatgg ataaaaatct    660

tcaggggaga ctttttatta gtcctgctaa tgaaaaaacc ctattatctg aagatatgag    720

aaaagaactt cagcgccagc aatgggagga agaagaaaga gaggccctga agaggcccat    780

ggggcccgta cattatgaag acattcggga aaatgatgga gatgttattg ggcctttgcc    840

accggagcca gaggctgtgc caaccccacg tcctgctgcc cagagtagca aagtagaagt    900

cattgtccag gagaggaagg acaccaagcc tggagtgcca cacatccggg agtgggaccg    960

cggaaaagaa ttttcctttg gatactggtc gaagaggcag tcagatctcc gggctgagag   1020

agatcctgag tttgccccgc cgtcagatta ctttgtgggt cagaagagaa ctggtttttc   1080

cagcagccag gcatggagca gacctgggcc agcacagagt gacccagggc agtgccctga   1140

ccagagccac ggacctagcc ctgaacatac gtcacccact cctgcccccg acaacccacc   1200

acaagccccc acagttactt tcaaaactct ggatgacatg atttcctatt acaaacaagt   1260

gacatgatct ttcaaagcac gctgacttgg gtttgtactt tgacagtgcc tttctctccc   1320

agagggagaa ataactttag gaactgaatt gtacctttgt cctgtccttt ccctaggagg   1380

cacagacttc gggttggatt tgtcagcaag gaggaaagtt atggaaactt tggccacttg   1440

gctgttcatt ttattctaag tgggataggg acatacctac ctggatttac atgtgagctg   1500

cgatagaata gaagtattta ttctgtaaaa ttagacactg agatgtgctt ataaccctgt   1560

ttcatatcta ctcccacgac ttactcatat ttaagggttc ttttccattc cttttgcaaa   1620

tccgagcatg caggtgtctt tattccaagg gttcagcttc cagatcagcc gatggaccat   1680

aggtcacgag gaatttctcc ctgtcaagca gtggaaaact gcatgggagg caaaatgctc   1740

tgttctccaa gaggacccgg aagtaatcac ataggaaatg ataaggaaga ccaggaggag   1800

ctcttcgtag tccagaaagg tagaagtggg agttgtttac ttaattttac tgtcatacca   1860

tgctattacc tacactcctg tgtgcagtgg gcattcagta aatgtgtgtt gaaggactgg   1920

gacgtacgtg gaggctgctg gacctggtca gagactgatg tgccttagcg gcaatggtta   1980

gagcttttca gtgcatccca cctccctgtc gcccccatgc tcggcttcct cacattcagg   2040

agcctgactt ggatcagact tggggctgca cagtggagca ggtgggttcc cgtgtcatta   2100

gtaataagga gagggttggg ggtgggcagg gctccagaaa gtcagcagtg tgcctgggca   2160

cccaccccat cctctacctg ccacacctca gagggttcct acagctgcac acaagcagtt   2220

gagagttgat gaccaggccc atagggctcc cacagctggt tcccaggcca gtgagtgctg   2280

tgagaataca gtagcacaag tccttgttct ctgaagagtg ggaaggagag gagtgagtga   2340

agtagcctgt cccctgcagg tcctctgcga tggcattgtc tcggttcccg cagtgctgca   2400

gtgtggaagg gagtgcccca tcctcattac agatgacaca ctggagtgtg gaggggtcga   2460

tgacttgtgc agggtcatat ggtacctaag gggcagatct cagacttaaa cacaattgat   2520

gtctaacccc tagacagtct ttttagtgcc ctctgctctc agtcttgttg ccctagtatc   2580

aagcaatctt agacaaacat cctgaattct tacaaactta cctctaaact ctgaggataa   2640

agttgccagt ccttttaatg gtcagcctaa tcattctgtc agcctaatcg ggtaattgct   2700

ttttttaata aatacacata aaaaccaact                                    2730


<210>  2229
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  2229

Met Asp Arg Arg Lys Lys Pro Leu Asp Val Thr Ala Ser Ser Leu Val 
1               5                   10                  15


Asp Leu Lys Ala Glu Leu Phe Arg Lys Gln Glu Glu Phe Lys Gln Glu 
            20                  25                  30


Lys Leu Leu Lys Asp Ser Gly Val Phe Gly Lys Pro Lys Thr Thr Asn 
        35                  40                  45


Lys Lys Pro Ser Ile Trp Ser Lys Gln Asn Val Gly Val Ser Asn Arg 
    50                  55                  60


Ala Glu Lys Asp Ala Glu Gln Lys Ile Glu Glu Gln Lys Thr Leu Asp 
65                  70                  75                  80


Lys Ala Arg Glu Lys Leu Glu Glu Lys Ala Lys Leu Tyr Glu Lys Met 
                85                  90                  95


Thr Lys Gly Asp Phe Ile Asp Glu Glu Val Glu Asp Met Tyr Leu Val 
            100                 105                 110


Asp Phe Thr Gln Lys Ile Ile Asp Lys Arg Lys Glu Met Glu Ala Ser 
        115                 120                 125


Gly Ala His Arg Asp Ser Gln Lys Ala Gly Glu Arg Asp Asp Asp Glu 
    130                 135                 140


Glu Asn Leu Pro Glu Gly Glu Ile Pro Pro Pro Gln Asp Pro Ser Glu 
145                 150                 155                 160


Glu Trp Val Asp Tyr Val Asp Ser Leu Gly Arg Ser Arg Arg Cys Met 
                165                 170                 175


Arg Lys Asp Leu Pro Asp Leu Leu Glu Met Asp Lys Asn Leu Gln Gly 
            180                 185                 190


Arg Leu Phe Ile Ser Pro Ala Asn Glu Lys Thr Leu Leu Ser Glu Asp 
        195                 200                 205


Met Arg Lys Glu Leu Gln Arg Gln Gln Trp Glu Glu Glu Glu Arg Glu 
    210                 215                 220


Ala Leu Lys Arg Pro Met Gly Pro Val His Tyr Glu Asp Ile Arg Glu 
225                 230                 235                 240


Asn Asp Gly Asp Val Ile Gly Pro Leu Pro Pro Glu Pro Glu Ala Val 
                245                 250                 255


Pro Thr Pro Arg Pro Ala Ala Gln Ser Ser Lys Val Glu Val Ile Val 
            260                 265                 270


Gln Glu Arg Lys Asp Thr Lys Pro Gly Val Pro His Ile Arg Glu Trp 
        275                 280                 285


Asp Arg Gly Lys Glu Phe Ser Phe Gly Tyr Trp Ser Lys Arg Gln Ser 
    290                 295                 300


Asp Leu Arg Ala Glu Arg Asp Pro Glu Phe Ala Pro Pro Ser Asp Tyr 
305                 310                 315                 320


Phe Val Gly Gln Lys Arg Thr Gly Phe Ser Ser Ser Gln Ala Trp Ser 
                325                 330                 335


Arg Pro Gly Pro Ala Gln Ser Asp Pro Gly Gln Cys Pro Asp Gln Ser 
            340                 345                 350


His Gly Pro Ser Pro Glu His Thr Ser Pro Thr Pro Ala Pro Asp Asn 
        355                 360                 365


Pro Pro Gln Ala Pro Thr Val Thr Phe Lys Thr Leu Asp Asp Met Ile 
    370                 375                 380


Ser Tyr Tyr Lys Gln Val Thr 
385                 390


<210>  2230
<211>  2958
<212>  DNA
<213>  Homo sapiens

<400>  2230
gaagacactt ccggttgcga cggaggtagg cttacgaggc ctgtgtcggg tagaaagggt     60

ccttcctgga ccgggaccct ctgccacgac catggaccgt aggaaaaagc ctttggacgt    120

cacggcctcc tcgttggtag atcttaaggc tgaactcttc cgaaagcaag aagaattcaa    180

acaagaaaaa cttctaaaag attctggagt ttttggaaaa ccaaaaacaa ctaacaagaa    240

accaagtatc tggagcaaac agaatgtagg cgtttcaaat cgagctgaga aggatgctga    300

acagaagatt gaagaacaga agactttaga caaagcaagg gaaaaattgg aagaaaaagc    360

caaattatat gaaaaaatga ctaaaggaga ctttatagat gaagaagtag aggatatgta    420

ccttgtggat ttcacacaga agatcataga caagcgcaaa gaaatggagg catctggtgc    480

ccatagagat tctcaaaagg caggagaaag ggacgacgat gaggaaaacc ttcctgaggg    540

agagatccct cctccccaag accccagtga agaatgggtg gattacgtgg actctttggg    600

gcgttcccgg cgctgtatga gaaaggattt gccagatctg ctggagatgg ataaaaatct    660

tcaggggaga ctttttatta gtcctgctaa tgaaaaaacc ctattatctg aagatatgag    720

aaaagaactt cagcgccagc aatgggagga agaagaaaga gaggccctga agaggcccat    780

ggggcccgta cattatgaag acattcggga aaatgaggcc cggcaacttg gtgttgggta    840

ttttgccttt gcccgagaca aagagttgag aaacaagcag atgaaaacct tagagatgct    900

gcgtgaacag acaacagatc agagaacaaa acgagaaaac ataaaggaaa agcgaaaggc    960

tatcttagag gcaagacttg ccaaacttcg acaaaaaaag atgaaaaaat caaaagaagg   1020

tggaacagaa gaagaaaata gagatggaga tgttattggg cctttgccac cggagccaga   1080

ggctgtgcca accccacgtc ctgctgccca gagtagcaaa gtagaagtca ttgtccagga   1140

gaggaaggac accaagcctg gagtgccaca catccgggag tgggaccgcg gaaaagaatt   1200

ttcctttgga tactggtcga agaggcagtc agatctccgg gctgagagag atcctgagtt   1260

tgccccgccg tcagattact ttgtgggtca gaagagaact ggtttttcca gcagccaggc   1320

atggagcaga cctgggccag cacagagtga cccagggcag tgccctgacc agagccacgg   1380

acctagccct gaacatacgt cacccactcc tgcccccgac aacccaccac aagcccccac   1440

agttactttc aaaactctgg atgacatgat ttcctattac aaacaagtga catgatcttt   1500

caaagcacgc tgacttgggt ttgtactttg acagtgcctt tctctcccag agggagaaat   1560

aactttagga actgaattgt acctttgtcc tgtcctttcc ctaggaggca cagacttcgg   1620

gttggatttg tcagcaagga ggaaagttat ggaaactttg gccacttggc tgttcatttt   1680

attctaagtg ggatagggac atacctacct ggatttacat gtgagctgcg atagaataga   1740

agtatttatt ctgtaaaatt agacactgag atgtgcttat aaccctgttt catatctact   1800

cccacgactt actcatattt aagggttctt ttccattcct tttgcaaatc cgagcatgca   1860

ggtgtcttta ttccaagggt tcagcttcca gatcagccga tggaccatag gtcacgagga   1920

atttctccct gtcaagcagt ggaaaactgc atgggaggca aaatgctctg ttctccaaga   1980

ggacccggaa gtaatcacat aggaaatgat aaggaagacc aggaggagct cttcgtagtc   2040

cagaaaggta gaagtgggag ttgtttactt aattttactg tcataccatg ctattaccta   2100

cactcctgtg tgcagtgggc attcagtaaa tgtgtgttga aggactggga cgtacgtgga   2160

ggctgctgga cctggtcaga gactgatgtg ccttagcggc aatggttaga gcttttcagt   2220

gcatcccacc tccctgtcgc ccccatgctc ggcttcctca cattcaggag cctgacttgg   2280

atcagacttg gggctgcaca gtggagcagg tgggttcccg tgtcattagt aataaggaga   2340

gggttggggg tgggcagggc tccagaaagt cagcagtgtg cctgggcacc caccccatcc   2400

tctacctgcc acacctcaga gggttcctac agctgcacac aagcagttga gagttgatga   2460

ccaggcccat agggctccca cagctggttc ccaggccagt gagtgctgtg agaatacagt   2520

agcacaagtc cttgttctct gaagagtggg aaggagagga gtgagtgaag tagcctgtcc   2580

cctgcaggtc ctctgcgatg gcattgtctc ggttcccgca gtgctgcagt gtggaaggga   2640

gtgccccatc ctcattacag atgacacact ggagtgtgga ggggtcgatg acttgtgcag   2700

ggtcatatgg tacctaaggg gcagatctca gacttaaaca caattgatgt ctaaccccta   2760

gacagtcttt ttagtgccct ctgctctcag tcttgttgcc ctagtatcaa gcaatcttag   2820

acaaacatcc tgaattctta caaacttacc tctaaactct gaggataaag ttgccagtcc   2880

ttttaatggt cagcctaatc attctgtcag cctaatcggg taattgcttt ttttaataaa   2940

tacacataaa aaccaact                                                 2958


<210>  2231
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  2231

Met Asp Arg Arg Lys Lys Pro Leu Asp Val Thr Ala Ser Ser Leu Val 
1               5                   10                  15


Asp Leu Lys Ala Glu Leu Phe Arg Lys Gln Glu Glu Phe Lys Gln Glu 
            20                  25                  30


Lys Leu Leu Lys Asp Ser Gly Val Phe Gly Lys Pro Lys Thr Thr Asn 
        35                  40                  45


Lys Lys Pro Ser Ile Trp Ser Lys Gln Asn Val Gly Val Ser Asn Arg 
    50                  55                  60


Ala Glu Lys Asp Ala Glu Gln Lys Ile Glu Glu Gln Lys Thr Leu Asp 
65                  70                  75                  80


Lys Ala Arg Glu Lys Leu Glu Glu Lys Ala Lys Leu Tyr Glu Lys Met 
                85                  90                  95


Thr Lys Gly Asp Phe Ile Asp Glu Glu Val Glu Asp Met Tyr Leu Val 
            100                 105                 110


Asp Phe Thr Gln Lys Ile Ile Asp Lys Arg Lys Glu Met Glu Ala Ser 
        115                 120                 125


Gly Ala His Arg Asp Ser Gln Lys Ala Gly Glu Arg Asp Asp Asp Glu 
    130                 135                 140


Glu Asn Leu Pro Glu Gly Glu Ile Pro Pro Pro Gln Asp Pro Ser Glu 
145                 150                 155                 160


Glu Trp Val Asp Tyr Val Asp Ser Leu Gly Arg Ser Arg Arg Cys Met 
                165                 170                 175


Arg Lys Asp Leu Pro Asp Leu Leu Glu Met Asp Lys Asn Leu Gln Gly 
            180                 185                 190


Arg Leu Phe Ile Ser Pro Ala Asn Glu Lys Thr Leu Leu Ser Glu Asp 
        195                 200                 205


Met Arg Lys Glu Leu Gln Arg Gln Gln Trp Glu Glu Glu Glu Arg Glu 
    210                 215                 220


Ala Leu Lys Arg Pro Met Gly Pro Val His Tyr Glu Asp Ile Arg Glu 
225                 230                 235                 240


Asn Glu Ala Arg Gln Leu Gly Val Gly Tyr Phe Ala Phe Ala Arg Asp 
                245                 250                 255


Lys Glu Leu Arg Asn Lys Gln Met Lys Thr Leu Glu Met Leu Arg Glu 
            260                 265                 270


Gln Thr Thr Asp Gln Arg Thr Lys Arg Glu Asn Ile Lys Glu Lys Arg 
        275                 280                 285


Lys Ala Ile Leu Glu Ala Arg Leu Ala Lys Leu Arg Gln Lys Lys Met 
    290                 295                 300


Lys Lys Ser Lys Glu Gly Gly Thr Glu Glu Glu Asn Arg Asp Gly Asp 
305                 310                 315                 320


Val Ile Gly Pro Leu Pro Pro Glu Pro Glu Ala Val Pro Thr Pro Arg 
                325                 330                 335


Pro Ala Ala Gln Ser Ser Lys Val Glu Val Ile Val Gln Glu Arg Lys 
            340                 345                 350


Asp Thr Lys Pro Gly Val Pro His Ile Arg Glu Trp Asp Arg Gly Lys 
        355                 360                 365


Glu Phe Ser Phe Gly Tyr Trp Ser Lys Arg Gln Ser Asp Leu Arg Ala 
    370                 375                 380


Glu Arg Asp Pro Glu Phe Ala Pro Pro Ser Asp Tyr Phe Val Gly Gln 
385                 390                 395                 400


Lys Arg Thr Gly Phe Ser Ser Ser Gln Ala Trp Ser Arg Pro Gly Pro 
                405                 410                 415


Ala Gln Ser Asp Pro Gly Gln Cys Pro Asp Gln Ser His Gly Pro Ser 
            420                 425                 430


Pro Glu His Thr Ser Pro Thr Pro Ala Pro Asp Asn Pro Pro Gln Ala 
        435                 440                 445


Pro Thr Val Thr Phe Lys Thr Leu Asp Asp Met Ile Ser Tyr Tyr Lys 
    450                 455                 460


Gln Val Thr 
465


<210>  2232
<211>  2185
<212>  DNA
<213>  Homo sapiens

<400>  2232
acttccggtt gcgacggagg taggcttacg aggcctgtgt cgggtagaaa gggtccttcc     60

tggaccggga ccctctgcca cgaccatgga ccgtaggaaa aagcctttgg acgtcacggc    120

ctcctcgttg gtagatctta aggctgaact cttccgaaag caagaagaat tcaaacaaga    180

aaaacttcta aaagattctg gagtttttgg aaaaccaaaa acaactaaca agaaaccaag    240

tatctggagc aaacagaatg taggcgtttc aaatcgagct gagaaggatg ctgaacagaa    300

gattgaagaa caaaacgaga aaacataaag gaaaagcgaa aggctatctt agaggcaaga    360

cttgccaaac ttcgacaaaa aaagatgaaa aaatcaaaag aaggtggaac agaagaagaa    420

aatagagatg gagatgttat tgggcctttg ccaccggagc cagaggctgt gccaacccca    480

cgtcctgctg cccagagtag caaagtagaa gtcattgtcc aggagaggaa ggacaccaag    540

cctggagtgc cacacatccg ggagtgggac cgcggaaaag aattttcctt tggatactgg    600

tcgaagaggc agtcagatct ccgggctgag agagatcctg agtttgcccc gccgtcagat    660

tactttgtgg gtcagaagag aactggtttt tccagcagcc aggcatggag cagacctggg    720

ccagcacaga gtgacccagg gcagtgccct gaccagagcc acggacctag ccctgaacat    780

acgtcaccca ctcctgcccc cgacaaccca ccacaagccc ccacagttac tttcaaaact    840

ctggatgaca tgatttccta ttacaaacaa gtgacatgat ctttcaaagc acgctgactt    900

gggtttgtac tttgacagtg cctttctctc ccagagggag aaataacttt aggaactgaa    960

ttgtaccttt gtcctgtcct ttccctagga ggcacagact tcgggttgga tttgtcagca   1020

aggaggaaag ttatggaaac tttggccact tggctgttca ttttattcta agtgggatag   1080

ggacatacct acctggattt acatgtgagc tgcgatagaa tagaagtatt tattctgtaa   1140

aattagacac tgagatgtgc ttataaccct gtttcatatc tactcccacg acttactcat   1200

atttaagggt tcttttccat tccttttgca aatccgagca tgcaggtgtc tttattccaa   1260

gggttcagct tccagatcag ccgatggacc ataggtcacg aggaatttct ccctgtcaag   1320

cagtggaaaa ctgcatggga ggcaaaatgc tctgttctcc aagaggaccc ggaagtaatc   1380

acataggaaa tgataaggaa gaccaggagg agctcttcgt agtccagaaa ggtagaagtg   1440

ggagttgttt acttaatttt actgtcatac catgctatta cctacactcc tgtgtgcagt   1500

gggcattcag taaatgtgtg ttgaaggact gggacgtacg tggaggctgc tggacctggt   1560

cagagactga tgtgccttag cggcaatggt tagagctttt cagtgcatcc cacctccctg   1620

tcgcccccat gctcggcttc ctcacattca ggagcctgac ttggatcaga cttggggctg   1680

cacagtggag caggtgggtt cccgtgtcat tagtaataag gagagggttg ggggtgggca   1740

gggctccaga aagtcagcag tgtgcctggg cacccacccc atcctctacc tgccacacct   1800

cagagggttc ctacagctgc acacaagcag ttgagagttg atgaccaggc ccatagggct   1860

cccacagctg gttcccaggc cagtgagtgc tgtgagaata cagtagcaca agtccttgtt   1920

ctctgaagag tgggaaggag aggagtgagt gaagtagcct gtcccctgca ggtcctctgc   1980

gatggcattg tctcggttcc cgcagtgctg cagtgtggaa gggagtgccc cctagtatca   2040

agcaatctta gacaaacatc ctgaattctt acaaacttac ctctaaactc tgaggataaa   2100

gttgccagtc cttttaatgg tcagcctaat cattctgtca gcctaatcgg gtaattgctt   2160

tttttaataa atacacataa aaacc                                         2185


<210>  2233
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  2233

Met Lys Lys Ser Lys Glu Gly Gly Thr Glu Glu Glu Asn Arg Asp Gly 
1               5                   10                  15


Asp Val Ile Gly Pro Leu Pro Pro Glu Pro Glu Ala Val Pro Thr Pro 
            20                  25                  30


Arg Pro Ala Ala Gln Ser Ser Lys Val Glu Val Ile Val Gln Glu Arg 
        35                  40                  45


Lys Asp Thr Lys Pro Gly Val Pro His Ile Arg Glu Trp Asp Arg Gly 
    50                  55                  60


Lys Glu Phe Ser Phe Gly Tyr Trp Ser Lys Arg Gln Ser Asp Leu Arg 
65                  70                  75                  80


Ala Glu Arg Asp Pro Glu Phe Ala Pro Pro Ser Asp Tyr Phe Val Gly 
                85                  90                  95


Gln Lys Arg Thr Gly Phe Ser Ser Ser Gln Ala Trp Ser Arg Pro Gly 
            100                 105                 110


Pro Ala Gln Ser Asp Pro Gly Gln Cys Pro Asp Gln Ser His Gly Pro 
        115                 120                 125


Ser Pro Glu His Thr Ser Pro Thr Pro Ala Pro Asp Asn Pro Pro Gln 
    130                 135                 140


Ala Pro Thr Val Thr Phe Lys Thr Leu Asp Asp Met Ile Ser Tyr Tyr 
145                 150                 155                 160


Lys Gln Val Thr 



<210>  2234
<211>  753
<212>  DNA
<213>  Homo sapiens

<400>  2234
gcgacggagg taggcttacg aggcctgtgt cgggtagaaa gggtccttcc tggaccggga     60

ccctctgcca cgaccatgga ccgtaggaaa aagcctttgg acgtcacggc ctcctcgttg    120

gtagatctta aggctgaact cttccgaaag caagaagaat tcaaacaaga aaaacttcta    180

aaagattctg gagtttttgg aaaaccaaaa acaactaaca agaaaccaag tatctggagc    240

aaacagaatg taggcgtttc aaatcgagct gagaaggatg ctgaacagaa gattgaagaa    300

cagaagactt tagacaaagc aagggaaaaa ttggaagaaa aagccaaatt atatgaaaaa    360

atgactaaag gagactttat agatgaagaa gtagaggata tgtaccttgt ggatttcaca    420

cagaagatca tagacaagcg caaagaaatg gaggcatctg gtgcccatag agattctcaa    480

aaggcaggag aaagggacga cgatgaggaa aaccttcctg agggagagat ccctcctccc    540

caagacccca gtgaagaatg gttggtaaca tcatggatta gctcagagga acatcctcag    600

acttgcgctg acattttggg agtgattttg ttgggttgtt atcgagccat ttctctttat    660

tcttcctggg tgttcttttg agacttccct ttaagttagg ttggattagg ttattatagt    720

tgtaaaaaca gtagctcaaa tgaagacata att                                 753


<210>  2235
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  2235

Met Asp Arg Arg Lys Lys Pro Leu Asp Val Thr Ala Ser Ser Leu Val 
1               5                   10                  15


Asp Leu Lys Ala Glu Leu Phe Arg Lys Gln Glu Glu Phe Lys Gln Glu 
            20                  25                  30


Lys Leu Leu Lys Asp Ser Gly Val Phe Gly Lys Pro Lys Thr Thr Asn 
        35                  40                  45


Lys Lys Pro Ser Ile Trp Ser Lys Gln Asn Val Gly Val Ser Asn Arg 
    50                  55                  60


Ala Glu Lys Asp Ala Glu Gln Lys Ile Glu Glu Gln Lys Thr Leu Asp 
65                  70                  75                  80


Lys Ala Arg Glu Lys Leu Glu Glu Lys Ala Lys Leu Tyr Glu Lys Met 
                85                  90                  95


Thr Lys Gly Asp Phe Ile Asp Glu Glu Val Glu Asp Met Tyr Leu Val 
            100                 105                 110


Asp Phe Thr Gln Lys Ile Ile Asp Lys Arg Lys Glu Met Glu Ala Ser 
        115                 120                 125


Gly Ala His Arg Asp Ser Gln Lys Ala Gly Glu Arg Asp Asp Asp Glu 
    130                 135                 140


Glu Asn Leu Pro Glu Gly Glu Ile Pro Pro Pro Gln Asp Pro Ser Glu 
145                 150                 155                 160


Glu Trp Leu Val Thr Ser Trp Ile Ser Ser Glu Glu His Pro Gln Thr 
                165                 170                 175


Cys Ala Asp Ile Leu Gly Val Ile Leu Leu Gly Cys Tyr Arg Ala Ile 
            180                 185                 190


Ser Leu Tyr Ser Ser Trp Val Phe Phe 
        195                 200


<210>  2236
<211>  1744
<212>  DNA
<213>  Homo sapiens

<400>  2236
acagtggtga atttctcctg tgtgttcctg tgtggatccc gacactcttc tcgctttaag     60

agagcctccc gcgcccctca ctccgcccct tcccaagtct ctgggctcgt caaagcttcc    120

cgagagccat ggttggtcca ggcaggcagt cggagcacct cgtggagcgg ctgctaaccc    180

agggtggggt ggggtggggt ggaggggtct gcttgtagta ctctcagtcc tgatgtcaca    240

ggcgcggcaa ggacatcgca aggaggagtc ggattacagt aaggatgggc agtgcagcag    300

gcagcccgag cgcactctcc agccgccggg gatcttagcc ctggaaaggc agcctgcaag    360

gcgctcatcc cgcggaggag gcacgctctc ggcgctcact gctctccacg ccggggacat    420

ttccaccgaa tgtagcatga aagggctctg ctctacgtgc cagccttggg tgagagctga    480

tgctgaagac accgcggtgg gattccagct gtctgattaa tgagaaacat aatgtatttt    540

ggtggtacat gccagagtcc tgctctcccg gcccttgtcc gtccaccagc ccctcctttg    600

caaccatcgc tggatattaa accatttctt ccctttcctc ttgacactgc agctgcagtc    660

aacctcttcc ccaatttcaa tgcgatggac ccgattcaga aagctgtaat aaaccataca    720

ttcggggttc ctcttcccca ccgaagaaag caaatcatat catgcaacat ttgccagttg    780

agatttaatt ctgatagcca ggctgcggcc cactacaaag gcacgaaaca tgccaagaag    840

ctcaaagcac tggaagccat gaaaaataag cagaaatctg taactgccaa ggacagcgca    900

aagactacct tcacctccat cactaccaat accatcaata ccagctctga caaaacagac    960

ggtactgcag ggacaccagc aatatcaacg acgacaactg tggaaatccg caaaagcagt   1020

gttatgacaa ctgagatcac ctctaaagtg gaaaaaagcc caacgacagc cactggcaat   1080

agctcatgtc cttctactga gaccgaggaa gaaaaggcaa aacggcttct ttactgttcg   1140

ctatgcaagg ttgctgtcaa ctctgcctcg cagctggagg cgcacaacag tggtactaag   1200

cacaaaacca tgttagaagc ccggaatgga agtggcacta tcaaagcctt tcctagggca   1260

ggagtgaaag gcaaaggacc tgttaataaa ggaaacacag gcctccaaaa taaaacattt   1320

cactgtgaaa tctgtgatgt gcacgtcaac tcggaaacgc aacttaaaca gcacattagc   1380

agtagaaggc acaaagacag agctgctggg aagcccccga aacctaaata cagtccttac   1440

aacaaactac agaagacagc acatccactg ggggtaaaat tagtattttc aaaagaacct   1500

tcaaagccat tggctccacg aattctacca aatcctctag cagctgcagc agccgcagca   1560

gcagtggcag tgagttcccc cttcagtctt cgaactgctc cagcagcaac actgttccag   1620

acttccgcgc ttcctccggc actcctgcgg ccagctcctg gacccattcg gaccgcccac   1680

actcctgtgc tgtttgctcc ttactaaatt ccaaatagga gtaattgtac tgcaataatt   1740

tttc                                                                1744


<210>  2237
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  2237

Met Arg Asn Ile Met Tyr Phe Gly Gly Thr Cys Gln Ser Pro Ala Leu 
1               5                   10                  15


Pro Ala Leu Val Arg Pro Pro Ala Pro Pro Leu Gln Pro Ser Leu Asp 
            20                  25                  30


Ile Lys Pro Phe Leu Pro Phe Pro Leu Asp Thr Ala Ala Ala Val Asn 
        35                  40                  45


Leu Phe Pro Asn Phe Asn Ala Met Asp Pro Ile Gln Lys Ala Val Ile 
    50                  55                  60


Asn His Thr Phe Gly Val Pro Leu Pro His Arg Arg Lys Gln Ile Ile 
65                  70                  75                  80


Ser Cys Asn Ile Cys Gln Leu Arg Phe Asn Ser Asp Ser Gln Ala Ala 
                85                  90                  95


Ala His Tyr Lys Gly Thr Lys His Ala Lys Lys Leu Lys Ala Leu Glu 
            100                 105                 110


Ala Met Lys Asn Lys Gln Lys Ser Val Thr Ala Lys Asp Ser Ala Lys 
        115                 120                 125


Thr Thr Phe Thr Ser Ile Thr Thr Asn Thr Ile Asn Thr Ser Ser Asp 
    130                 135                 140


Lys Thr Asp Gly Thr Ala Gly Thr Pro Ala Ile Ser Thr Thr Thr Thr 
145                 150                 155                 160


Val Glu Ile Arg Lys Ser Ser Val Met Thr Thr Glu Ile Thr Ser Lys 
                165                 170                 175


Val Glu Lys Ser Pro Thr Thr Ala Thr Gly Asn Ser Ser Cys Pro Ser 
            180                 185                 190


Thr Glu Thr Glu Glu Glu Lys Ala Lys Arg Leu Leu Tyr Cys Ser Leu 
        195                 200                 205


Cys Lys Val Ala Val Asn Ser Ala Ser Gln Leu Glu Ala His Asn Ser 
    210                 215                 220


Gly Thr Lys His Lys Thr Met Leu Glu Ala Arg Asn Gly Ser Gly Thr 
225                 230                 235                 240


Ile Lys Ala Phe Pro Arg Ala Gly Val Lys Gly Lys Gly Pro Val Asn 
                245                 250                 255


Lys Gly Asn Thr Gly Leu Gln Asn Lys Thr Phe His Cys Glu Ile Cys 
            260                 265                 270


Asp Val His Val Asn Ser Glu Thr Gln Leu Lys Gln His Ile Ser Ser 
        275                 280                 285


Arg Arg His Lys Asp Arg Ala Ala Gly Lys Pro Pro Lys Pro Lys Tyr 
    290                 295                 300


Ser Pro Tyr Asn Lys Leu Gln Lys Thr Ala His Pro Leu Gly Val Lys 
305                 310                 315                 320


Leu Val Phe Ser Lys Glu Pro Ser Lys Pro Leu Ala Pro Arg Ile Leu 
                325                 330                 335


Pro Asn Pro Leu Ala Ala Ala Ala Ala Ala Ala Ala Val Ala Val Ser 
            340                 345                 350


Ser Pro Phe Ser Leu Arg Thr Ala Pro Ala Ala Thr Leu Phe Gln Thr 
        355                 360                 365


Ser Ala Leu Pro Pro Ala Leu Leu Arg Pro Ala Pro Gly Pro Ile Arg 
    370                 375                 380


Thr Ala His Thr Pro Val Leu Phe Ala Pro Tyr 
385                 390                 395


<210>  2238
<211>  4441
<212>  DNA
<213>  Homo sapiens

<400>  2238
gtaaacgttt tccatcaggg ccagacagaa gaggccttgt ggaccatatg gtctctgttg     60

caattactca aatctgcaac catagacgat gtgtaaatga atgggtatgg ctgggttccc    120

gtaaaacatt atttacaaaa caggcagttg gcctagattg ccagccccct tagcagattt    180

tcagcttctg aaaaggcagg ctctgtgtct catttgcctt gtgtctagca gaggccatgc    240

agagagtgag tgctccataa atactcattt ggggattatt aaatgaagca aaaggctgga    300

atttgagctg cacacataca ggcctcatga cccagtgttt caattcctag gtcataccca    360

acaggattgc ctgcacgtag tcaccggagg gcatgtgcca gggtgtccat ggcagcactg    420

tttgtcatgg ccccaaactg gaatctaccc cagtgccagt tgacaggaga taattaaatc    480

aattgcagca tattcacaaa atggaatact atgcagcaat taaaataaat gtgctctatg    540

taaaaatatg gatgaatctc acaaacacga tgttgaatta agatgaagct acacataaaa    600

tattacatat tgtatgactc cattcacaaa aagttgaaag gcaggtaaaa cacatctatg    660

ctgtgagaag tgaggagagt ggttaccttt ggtggtggag gtgggctgga aggggttctc    720

gggagcttcc tgaagcactg gctgtgcttt tctccttgat cagtgtgctg gctatggggg    780

tatgctcagt ttgtgaaaat tcttcaatcc gtgcacttag gatttgtgta cttttctgta    840

tgaatgttat ggttgcataa agcattccat ttaaaacaaa acaaaaagta aagtagtttg    900

tccaaacatt atttaaccaa agactactat cagccgttct gattttctgt ccaatgctct    960

tcaactgctg accccaaata tgggctcttt gtcctagaaa ggggaatatg gaagccctgt   1020

ctctcctttc gtcatctctt tcacccaggt gtacaagagc agagcccggc attgagtatt   1080

ttgaagatgg agccaatgtc cctggtctgc ccctgcctcg gcatccccca ccacctctgg   1140

catccatacc cgtggtgggt gctgtaacgg catctgggct ttgtcatctc ctttgcagaa   1200

catcgtagct gtgggagctg ggttctgcga cggcctccgc tgtggagaca acaccaaagc   1260

ggccgtcatc cgcctgggac tcatggaaat gattgctttt gccaggatct tctgcaaagg   1320

ccaagtgtct acagccacct tcctagagag ctgcggggtg gccgacctga tcaccacctg   1380

ttacggaggg cggaaccgca gggtggccga ggccttcgcc agaactggga agaccattga   1440

agagttggag aaggagatgc tgaatgggca aaagctccaa ggaccgcaga cttctgctga   1500

agtgtaccgc atcctcaaac agaagggact actggacaag tttccattgt ttactgcagt   1560

gtatcagatc tgctacgaaa gcagaccagt tcaagagatg ttgtcttgtc ttcagagcca   1620

tccagagcat acataaagtg aatcatgcaa cgtgttgggg gaagttctgc ctttctgatc   1680

aatcttttgg gttcacgtgg aaaccaggac ttggcaacat gatgtttgac tgtaatctca   1740

tcacggatat gtatgaattt ttacaggttc gtttttgaat tgtgagaggc agttcattag   1800

caaagatgta ctgggcagta actaaacaca catgcaaaca tgtgaatggt ggtttattcc   1860

tcattctgtg gatgtttcta tgagccaaaa tttgatgtct ttttttcaaa attgcttatg   1920

aaatttccac acaatcgtag cttataagat tggaacgatc tcagccaaat attttaggtg   1980

taattcatat gtatttgagt ggaggatttt ttttctcatt tttctagtgt taaattttaa   2040

ccagcattaa catggtagag tggaggagtg agtgtgttca aagatcaaca tatttaactt   2100

ttaaacacta tctcaaagcc agcataatta actactttga ttgtgggctg acctttgttt   2160

ttttaacaat caggcatttt taattagata atccactcat gtatttcccc ctcactgcag   2220

ttgtctgcat ttttagcctc ttttctcttc gttagttgtc agaatatgcc ttcgtcaagg   2280

ctcagaggta acaagacaga aaattcatct gggattttcc tgctgtggct ggcacattct   2340

tctgattaac agacacttgt atgatgcttt aggctagtta gtgcattttt tagcaaacat   2400

ttatcttaaa catcacagat ccactggggg gtgcaagggg ctactgttag tcctcttgtt   2460

agatgcagtc actcctcctg gtcacctagt gagcagggac agagccagga gtcaagtgca   2520

gtgccaaggt gcatgaccct ctgagaagtc actgggctga tttgacctcc gactcattgg   2580

ttgtgcaaat gccatgtgca gcctttcctg aggccatagg agggcttcct gcagctgaga   2640

tctatgcagg ccatcctctc aacaagtgcc actccaaggg cggtcctcgg tgcagcagca   2700

tcagcttcac ttgtgggggg gtgggggaag gggcggtctc agaaatgcag gttcccaggt   2760

cccaccctgg acttctgaag gggtgtggca tctgtgtttc tgatgcttac tacaatatgt   2820

gaaccactac tttagaaaat ctgctttaac ttggtattcc tctaattgtg ttccctagga   2880

aatgactgtc ccaagagcca gtgattattc caggtgttcc ctggaaaggt caagtgagtc   2940

tgggaaacac tatgtctgta cacctcttga aggtgtcgaa tgtatgttta tacatcagtg   3000

gaacccattt ttctagccta gcaagtccca aacacattac actgaagaga ttttggtgag   3060

gaaacttgct ggagttttca gggaacactg ttctaggctt aggtgacctt aggatcactc   3120

aagtagaccc ttcactccct gcgagaaatt aggatgaata actacctgtg gcattgttgg   3180

ttctgaactt ttacagttca ggcctgctgt gaatctttga tgaagcttta aggtgacact   3240

gttgtacaag atgtcagctt tgctgaaacg cacattacct ggaataagtg ctttaattgt   3300

agaattagaa tgggatttac tgtactgttt taaatgagat tggcttcaga atccattaca   3360

gttaccttac atagcacttg atacgtgtta aatgaacata tgaatgtaat ttatatattc   3420

ctagaattta agttactttg tgagatttgg gcctgtccct caatgccagt ttaggatttc   3480

tttttttcta taccttgaaa tgattataaa atagattttc atgggaattt taaaaactct   3540

atccaaaaca tttttggagc attttaaagc cccatacaca gaagtatacg aaagcacaca   3600

aaacactcca agtttcagca gttttagcgc caccattaac ccactttgct tgtctcatga   3660

aaaatctttg ttaaagtttg tacacaggta acaaaaagtt actttaaaag atatataaag   3720

ggctgtaagc taattgtggt gtctagtaag tagcataatg agatgtgagg agttggaact   3780

ttgcgtgttt tgcgtatttt catctgcatt cagcttctta ctctgggttt gtactcgagt   3840

gttatttctt tacaaatgcc cttgtaatta ccactctgaa gtctgctgac tgtgtctctt   3900

gaacatactt aggatattct gcacattatg gaaaaaggta aattttagaa gtttctgctc   3960

tactaactgt agatatttat gactctgcga gttatctatt tttataacca cctgtggtcc   4020

attgttcatt ttaattcaca tttcttatga agtatggtaa cagggaggga gacacctaga   4080

ttagcagctc aatttgtact acttcagcca atctgtgaat gtaaaaacta cactgttgcc   4140

ttgctaggat ccaccctcct ataatatgga acaaatatct gaatgaaatc caccctagga   4200

gacggagtca aactaaactt gtggtttttc atttaacttt tgactacagc atggccccat   4260

ggcatccaca ccaagagggt gttgtgatga ggtgccggtg tgcaaaggga actttagttt   4320

ttccactggt tcttatctgc tagcctttta catacatgtg tactatattt gtttatagac   4380

tgtaggtgga tatataattt aaaagcttga tttaataaac atttaacccc ctaaacttgc   4440

a                                                                   4441


<210>  2239
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  2239

Met Glu Met Ile Ala Phe Ala Arg Ile Phe Cys Lys Gly Gln Val Ser 
1               5                   10                  15


Thr Ala Thr Phe Leu Glu Ser Cys Gly Val Ala Asp Leu Ile Thr Thr 
            20                  25                  30


Cys Tyr Gly Gly Arg Asn Arg Arg Val Ala Glu Ala Phe Ala Arg Thr 
        35                  40                  45


Gly Lys Thr Ile Glu Glu Leu Glu Lys Glu Met Leu Asn Gly Gln Lys 
    50                  55                  60


Leu Gln Gly Pro Gln Thr Ser Ala Glu Val Tyr Arg Ile Leu Lys Gln 
65                  70                  75                  80


Lys Gly Leu Leu Asp Lys Phe Pro Leu Phe Thr Ala Val Tyr Gln Ile 
                85                  90                  95


Cys Tyr Glu Ser Arg Pro Val Gln Glu Met Leu Ser Cys Leu Gln Ser 
            100                 105                 110


His Pro Glu His Thr 
        115


<210>  2240
<211>  2125
<212>  DNA
<213>  Homo sapiens

<400>  2240
tttctcttcg ttagttgtca gaatatgcct tcgtcaaggc tcagaggtaa caagacagaa     60

aattcatctg ggattttcct gctgtggctg gcacattctt ctgattaaca gacacttgta    120

tgatgcttta ggctagttag tgcatttttt agcaaacatt tatcttaaac atcacagatc    180

cactgggggg tgcaaggggc tactgttagt cctcttgtta gatgcagtca ctcctcctgg    240

tcacctagtg agcagggaca gagccaggag tcaagtgcag tgccaaggtg catgaccctc    300

tgagaagtca ctgggctgat ttgacctccg actcattggt tgtgcaaatg ccatgtgcag    360

cctttcctga ggccatagga gggcttcctg cagctgagat ctatgcaggc catcctctca    420

acaagtgcca ctccaagggc ggtcctcggt gcagcagcat cagcttcact tgtggggggg    480

tgggggaagg ggcggtctca gaaatgcagg ttcccaggtc ccaccctgga cttctgaagg    540

ggtgtggcat ctgtgtttct gatgcttact acaatatgtg aaccactact ttagaaaatc    600

tgctttaact tggtattcct ctaattgtgt tccctaggaa atgactgtcc caagagccag    660

tgattattcc aggtgttccc tggaaaggtc aattttctag cctagcaagt cccaaacaca    720

ttacactgaa gagattttgg tgaggaaact tgctggagtt ttcagggaac actgttctag    780

gcttaggtga ccttaggatc actcaagtag acccttcact ccctgcgaga aattaggatg    840

aataactacc tgtggcattg ttggttctga acttttacag ttcaggcctg ctgtgaatct    900

ttgatgaagc tttaaggtga cactgttgta caagatgtca gctttgctga aacgcacatt    960

acctggaata agtgctttaa ttgtagaatt agaatgggat ttactgtact gttttaaatg   1020

agattggctt cagaatccat tacagttacc ttacatagca cttgatacgt gttaaatgaa   1080

catatgaatg taatttatat attcctagaa tttaagttac tttgtgagat ttgggcctgt   1140

ccctcaatgc cagtttagga tttctttttt tctatacctt gaaatgatta taaaatagat   1200

tttcatggga attttaaaaa ctctatccaa aacatttttg gagcatttta aagccccata   1260

cacagaagta tacgaaagca cacaaaacac tccaagtttc agcagtttta gcgccaccat   1320

taacccactt tgcttgtctc atgaaaaatc tttgttaaag tttgtacaca ggtaacaaaa   1380

agttacttta aaagatatat aaagggctgt aagctaattg tggtgtctag taagtagcat   1440

aatgagatgt gaggagttgg aactttgcgt gttttgcgta ttttcatctg cattcagctt   1500

cttactctgg gtttgtactc gagtgttatt tctttacaaa tgcccttgta attaccactc   1560

tgaagtctgc tgactgtgtc tcttgaacat acttaggata ttctgcacat tatggaaaaa   1620

ggtaaatttt agaagtttct gctctactaa ctgtagatat ttatgactct gcgagttatc   1680

tatttttata accacctgtg gtccattgtt cattttaatt cacatttctt atgaagtatg   1740

gtaacaggga gggagacacc tagattagca gctcaatttg tactacttca gccaatctgt   1800

gaatgtaaaa actacactgt tgccttgcta ggatccaccc tcctataata tggaacaaat   1860

atctgaatga aatccaccct aggagacgga gtcaaactaa acttgtggtt tttcatttaa   1920

cttttgacta cagcatggcc ccatggcatc cacaccaaga gggtgttgtg atgaggtgcc   1980

ggtgtgcaaa gggaacttta gtttttccac tggttcttat ctgctagcct tttacataca   2040

tgtgtactat atttgtttat agactgtagg tggatatata atttaaaagc ttgatttaat   2100

aaacatttaa ccccctaaac ttgca                                         2125


<210>  2241
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  2241

Met Pro Cys Ala Ala Phe Pro Glu Ala Ile Gly Gly Leu Pro Ala Ala 
1               5                   10                  15


Glu Ile Tyr Ala Gly His Pro Leu Asn Lys Cys His Ser Lys Gly Gly 
            20                  25                  30


Pro Arg Cys Ser Ser Ile Ser Phe Thr Cys Gly Gly Val Gly Glu Gly 
        35                  40                  45


Ala Val Ser Glu Met Gln Val Pro Arg Ser His Pro Gly Leu Leu Lys 
    50                  55                  60


Gly Cys Gly Ile Cys Val Ser Asp Ala Tyr Tyr Asn Met 
65                  70                  75


<210>  2242
<211>  1220
<212>  DNA
<213>  Homo sapiens

<400>  2242
atgtttatac atcagtggaa cccatttttc tagcctagca agtcccaaac acattacact     60

gaagagattt tggtgaggaa acttgctgga gttttcaggg aacactgttc taggcttagg    120

tgaccttagg atcactcaag tagacccttc actccctgcg agaaattagg atgaataact    180

acctgtggca ttgttggttc tgaactttta cagttcaggc ctgctgtgaa tctttgatga    240

agctttaagg tgacactgtt gtacaagatg tcagctttgc tgaaacgcac attacctgga    300

ataagtgctt taattgtaga attagaatgg gatttactgt actgttttaa atgagattgg    360

cttcagaatc cattacagtt accttacata gcacttgata cgtgttaaat gaacatatga    420

atgtaattta tatattccta gaatttaagt tactttgtga gatttgggcc tgtccctcaa    480

tgccagttta ggatttcttt ttttctatac cttgaaatga ttataaaata gattttcatg    540

ggaattttaa aaactctatc caaaacattt ttggagcatt ttaaagcccc atacacagaa    600

gtatacgaaa gcacacaaaa cactccaagt ttcagcagtt ttagcgccac cattaaccca    660

ctttgcttgt ctcatgaaaa atctttgtta aagtttgtac acaggtaaca aaaagttact    720

ttaaaagata tataaagggc tgtaagctaa ttgtggtgtc tagtaagtag cataatgaga    780

tgtgaggagt tggaactttg cgtgttttgc gtattttcat ctgcattcag cttcttactc    840

tgggtttgta ctcgagtgtt atttctttac aaatgccctt gtaattacca ctctgaagtc    900

tgctgactgt gtctcttgaa catacttagg atattctgca cattatggaa caaatatctg    960

aatgaaatcc accctaggag acggagtcaa actaaacttg tggtttttca tttaactttt   1020

gactacagca tggccccatg gcatccacac caagagggtg ttgtgatgag gtgccggtgt   1080

gcaaagggaa ctttagtttt tccactggtt cttatctgct agccttttac atacatgtgt   1140

actatatttg tttatagact gtaggtggat atataattta aaagcttgat ttaataaaca   1200

tttaaccccc taaacttgca                                               1220


<210>  2243
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  2243

Met Gly Ile Leu Lys Thr Leu Ser Lys Thr Phe Leu Glu His Phe Lys 
1               5                   10                  15


Ala Pro Tyr Thr Glu Val Tyr Glu Ser Thr Gln Asn Thr Pro Ser Phe 
            20                  25                  30


Ser Ser Phe Ser Ala Thr Ile Asn Pro Leu Cys Leu Ser His Glu Lys 
        35                  40                  45


Ser Leu Leu Lys Phe Val His Arg 
    50                  55


<210>  2244
<211>  355
<212>  DNA
<213>  Homo sapiens

<400>  2244
ggagcagggg atgccttcat gggagctgcg ctatcacagt ggtgagtcct gatgccttgc     60

ctgtgagggc cttcacaacc ttcagagcat gatggcattg ccagagagaa gagaattcac    120

catggacacc tagcctagtg cctggcagat ggtgttaaag aaacatccga agatcggcta    180

attgaaggtg gtccacagac cagtgacatc atcatcaccc gggagcctat tagaaatgca    240

gaatctcagg ccccacccct gacctgctga actggaatat gcattttaac aaaatcccca    300

ggtgctttgt gtgcacgtta gatttaagaa atgccacctt gagaccctca ttctc         355


<210>  2245
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  2245

Cys Leu Ala Asp Gly Val Lys Glu Thr Ser Glu Asp Arg Leu Ile Glu 
1               5                   10                  15


Gly Gly Pro Gln Thr Ser Asp Ile Ile Ile Thr Arg Glu Pro Ile Arg 
            20                  25                  30


Asn Ala Glu Ser Gln Ala Pro Pro Leu Thr Cys 
        35                  40


<210>  2246
<211>  1172
<212>  DNA
<213>  Homo sapiens

<400>  2246
ggcctccacc gccttccccg gctgcccggc agcctcccct cgctcgctct cctcttcctc     60

tagggcccca gcgcagctcg ggagcccgcg caccgaggcg ctaggggcac cgcgcactag    120

agggacaccc gccgcgcctg gacagccccc ggcgggcgcc cccctcgcac ctcctgcccc    180

gcgcgggccg cgctcccctc ccccgcgcct gtgtccccag ggcgcagggc cgcgcgtcca    240

gccccagacc cgccggggtc cctggggacg cgccagcccg gcagtggctc gacgatggag    300

gagccgcagc gcgcccgctc gcacacagtc accaccaccg ccagctcctt cgcagagaac    360

ttctccacca gcagcagcag cttcgcctac gaccgggagt tcctccgcac cctgcccggc    420

ttcctcatcg tggccgagat cgttctgggg ctgctggtat ggacgcttat tgctggaact    480

gagtacttcc gggtccccgc atttggctgg gtcatgtttg tagctgtatt ttactgggtc    540

ctcaccgtct tcttcctcat tatctacata acaatgacct acaccaggat tccccaggtg    600

ccctggacaa cagtgggcct gtgctttaac ggcagtgcct tcgtcttgta cctctctgcc    660

gctgttgtag atgcatcttc cgtctcccct gagagggaca gtcacaactt caacagctgg    720

gcggcctcat cgttctttgc cttcctggtc accatctgct acgctggaaa tacatatttc    780

agttttatag catggagatc caggaccata cagtgattta ccattttgat aattaaaagg    840

aaaaaaaaag gaagactctc actgtaaaaa cagctgtagg tataatgtat attcccagag    900

aattgtattt aactaattaa tgttttttat attcttaaat ttgctcacaa attgtggttt    960

gttacaatta aactggatac ttatttgcaa agtgttgtag cttataatga actcttaagt   1020

atcttattaa tgtattaatg tcttcataga tcatattttc ttagacaatg tttaaataga   1080

taaattgcta atattgagaa tgtgtcaagt ttgtaaacct aacttttaag atgccagatt   1140

cttttttgat taaatgttgc aaaatcccaa gt                                 1172


<210>  2247
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  2247

Met Glu Glu Pro Gln Arg Ala Arg Ser His Thr Val Thr Thr Thr Ala 
1               5                   10                  15


Ser Ser Phe Ala Glu Asn Phe Ser Thr Ser Ser Ser Ser Phe Ala Tyr 
            20                  25                  30


Asp Arg Glu Phe Leu Arg Thr Leu Pro Gly Phe Leu Ile Val Ala Glu 
        35                  40                  45


Ile Val Leu Gly Leu Leu Val Trp Thr Leu Ile Ala Gly Thr Glu Tyr 
    50                  55                  60


Phe Arg Val Pro Ala Phe Gly Trp Val Met Phe Val Ala Val Phe Tyr 
65                  70                  75                  80


Trp Val Leu Thr Val Phe Phe Leu Ile Ile Tyr Ile Thr Met Thr Tyr 
                85                  90                  95


Thr Arg Ile Pro Gln Val Pro Trp Thr Thr Val Gly Leu Cys Phe Asn 
            100                 105                 110


Gly Ser Ala Phe Val Leu Tyr Leu Ser Ala Ala Val Val Asp Ala Ser 
        115                 120                 125


Ser Val Ser Pro Glu Arg Asp Ser His Asn Phe Asn Ser Trp Ala Ala 
    130                 135                 140


Ser Ser Phe Phe Ala Phe Leu Val Thr Ile Cys Tyr Ala Gly Asn Thr 
145                 150                 155                 160


Tyr Phe Ser Phe Ile Ala Trp Arg Ser Arg Thr Ile Gln 
                165                 170


<210>  2248
<211>  990
<212>  DNA
<213>  Homo sapiens

<400>  2248
ccgccttccc cggctgcccg gcagcctccc ctcgctcgct ctcctcttcc tctagggccc     60

cagcgcagct cgggagcccg cgcaccgagg cgctaggggc accgcgcact agagggacac    120

ccgccgcgcc tggacagccc ccggcgggcg cccccctcgc acctcctgcc ccgcgcgggc    180

cgcgctcccc tcccccgcgc ctgtgtcccc agggcgcagg gccgcgcgtc cagccccaga    240

cccgccgggg tccctgggga cgcgccagcc cggcagtggc tcgacgatgg aggagccgca    300

gcgcgcccgc tcgcacacag tcaccaccac cgccagctcc ttcgcagaga acttctccac    360

cagcagcagc agcttcgcct acgaccggga gttcctccgc accctgcccg gcttcctcat    420

cgtggccgag atcggcctgt gctttaacgg cagtgccttc gtcttgtacc tctctgccgc    480

tgttgtagat gcatcttccg tctcccctga gagggacagt cacaacttca acagctgggc    540

ggcctcatcg ttctttgcct tcctggtcac catctgctac gctggaaata catatttcag    600

ttttatagca tggagatcca ggaccataca gtgatttacc attttgataa ttaaaaggaa    660

aaaaaaagga agactctcac tgtaaaaaca gctgtaggta taatgtatat tcccagagaa    720

ttgtatttaa ctaattaatg ttttttatat tcttaaattt gctcacaaat tgtggtttgt    780

tacaattaaa ctggatactt atttgcaaag tgttgtagct tataatgaac tcttaagtat    840

cttattaatg tattaatgtc ttcatagatc atattttctt agacaatgtt taaatagata    900

aattgctaat attgagaatg tgtcaagttt gtaaacctaa cttttaagat gccagattct    960

tttttgatta aatgttgcaa aatcccaagt                                     990


<210>  2249
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  2249

Met Glu Glu Pro Gln Arg Ala Arg Ser His Thr Val Thr Thr Thr Ala 
1               5                   10                  15


Ser Ser Phe Ala Glu Asn Phe Ser Thr Ser Ser Ser Ser Phe Ala Tyr 
            20                  25                  30


Asp Arg Glu Phe Leu Arg Thr Leu Pro Gly Phe Leu Ile Val Ala Glu 
        35                  40                  45


Ile Gly Leu Cys Phe Asn Gly Ser Ala Phe Val Leu Tyr Leu Ser Ala 
    50                  55                  60


Ala Val Val Asp Ala Ser Ser Val Ser Pro Glu Arg Asp Ser His Asn 
65                  70                  75                  80


Phe Asn Ser Trp Ala Ala Ser Ser Phe Phe Ala Phe Leu Val Thr Ile 
                85                  90                  95


Cys Tyr Ala Gly Asn Thr Tyr Phe Ser Phe Ile Ala Trp Arg Ser Arg 
            100                 105                 110


Thr Ile Gln 
        115


<210>  2250
<211>  8053
<212>  DNA
<213>  Homo sapiens

<400>  2250
gggcgagcgc ctccgtcccc ggatgtgagc tccggctgcc cgcggtcccg agccagcggc     60

ggcgcgggcg gcggcggcgg gcaccgggca ccgcggcggg cgggcagacg ggcgggcatg    120

gggggagcgc cgagcggccc cggcggccgg gccggcatca ccgcggcgtc tctccgctag    180

aggaggggac aagccagttc tcctttgcag caaaaaatta catgtatata ttattaagat    240

aatatataca ttggatttta tttttttaaa aagtttattt tgctccattt ttgaaaaaga    300

gagagcttgg gtggcgagcg gttttttttt taaatcaatt atccttattt tctgttattt    360

gtccccgtcc ctccccaccc ccctgctgaa gcgagaataa gggcagggac cgcggctcct    420

acctcttggt gatccccttc cccattccgc ccccgcctca acgcccagca cagtgccctg    480

cacacagtag tcgctcaata aatgttcgtg gatgatgatg atgatgatga tgaaaaaaat    540

gcagcatcaa cggcagcagc aagcggacca cgcgaacgag gcaaactatg caagaggcac    600

cagacttcct ctttctggtg aaggaccaac ttctcagccg aatagctcca agcaaactgt    660

cctgtcttgg caagctgcaa tcgatgctgc tagacaggcc aaggctgccc aaactatgag    720

cacctctgca cccccacctg taggatctct ctcccaaaga aaacgtcagc aatacgccaa    780

gagcaaaaaa cagggtaact cgtccaacag ccgacctgcc cgcgcccttt tctgtttatc    840

actcaataac cccatccgaa gagcctgcat tagtatagtg gaatggaaac catttgacat    900

atttatatta ttggctattt ttgccaattg tgtggcctta gctatttaca tcccattccc    960

tgaagatgat tctaattcaa caaatcataa cttggaaaaa gtagaatatg ccttcctgat   1020

tatttttaca gtcgagacat ttttgaagat tatagcgtat ggattattgc tacatcctaa   1080

tgcttatgtt aggaatggat ggaatttact ggattttgtt atagtaatag taggattgtt   1140

tagtgtaatt ttggaacaat taaccaaaga aacagaaggc gggaaccact caagcggcaa   1200

atctggaggc tttgatgtca aagccctccg tgcctttcga gtgttgcgac cacttcgact   1260

agtgtcagga gtgcccagtt tacaagttgt cctgaactcc attataaaag ccatggttcc   1320

cctccttcac atagcccttt tggtattatt tgtaatcata atctatgcta ttataggatt   1380

ggaacttttt attggaaaaa tgcacaaaac atgttttttt gctgactcag atatcgtagc   1440

tgaagaggac ccagctccat gtgcgttctc agggaatgga cgccagtgta ctgccaatgg   1500

cacggaatgt aggagtggct gggttggccc gaacggaggc atcaccaact ttgataactt   1560

tgcctttgcc atgcttactg tgtttcagtg catcaccatg gagggctgga cagatgtgct   1620

ctactggatg aatgatgcta tgggatttga attgccctgg gtgtattttg tcagtctcgt   1680

catctttggg tcatttttcg tactaaatct tgtacttggt gtattgagcg gagaattctc   1740

aaaggaaaga gagaaggcaa aagcacgggg agatttccag aagctccggg agaagcagca   1800

gctggaggag gatctaaagg gctacttgga ttggatcacc caagctgagg acatcgatcc   1860

ggagaatgag gaagaaggag gagaggaagg caaacgaaat actagcatgc ccaccagcga   1920

gactgagtct gtgaacacag agaacgtcag cggtgaaggc gagaaccgag gctgctgtgg   1980

aagtctctgt caagccatct caaaatccaa actcagccga cgctggcgtc gctggaaccg   2040

attcaatcgc agaagatgta gggccgccgt gaagtctgtc acgttttact ggctggttat   2100

cgtcctggtg tttctgaaca ccttaaccat ttcctctgag cactacaatc agccagattg   2160

gttgacacag attcaagata ttgccaacaa agtcctcttg gctctgttca cctgcgagat   2220

gctggtaaaa atgtacagct tgggcctcca agcatatttc gtctctcttt tcaaccggtt   2280

tgattgcttc gtggtgtgtg gtggaatcac tgagacgatc ttggtggaac tggaaatcat   2340

gtctcccctg gggatctctg tgtttcggtg tgtgcgcctc ttaagaatct tcaaagtgac   2400

caggcactgg acttccctga gcaacttagt ggcatcctta ttaaactcca tgaagtccat   2460

cgcttcgctg ttgcttctgc tttttctctt cattatcatc ttttccttgc ttgggatgca   2520

gctgtttggc ggcaagttta attttgatga aacgcaaacc aagcggagca cctttgacaa   2580

tttccctcaa gcacttctca cagtgttcca gatcctgaca ggcgaagact ggaatgctgt   2640

gatgtacgat ggcatcatgg cttacggggg cccatcctct tcaggaatga tcgtctgcat   2700

ctacttcatc atcctcttca tttgtggtaa ctatattcta ctgaatgtct tcttggccat   2760

cgctgtagac aatttggctg atgctgaaag tctgaacact gctcagaaag aagaagcgga   2820

agaaaaggag aggaaaaaga ttgccagaaa agagagccta gaaaataaaa agaacaacaa   2880

accagaagtc aaccagatag ccaacagtga caacaaggtt acaattgatg actatagaga   2940

agaggatgaa gacaaggacc cctatccgcc ttgcgatgtg ccagtagggg aagaggaaga   3000

ggaagaggag gaggatgaac ctgaggttcc tgccggaccc cgtcctcgaa ggatctcgga   3060

gttgaacatg aaggaaaaaa ttgcccccat ccctgaaggg agcgctttct tcattcttag   3120

caagaccaac ccgatccgcg taggctgcca caagctcatc aaccaccaca tcttcaccaa   3180

cctcatcctt gtcttcatca tgctgagcag cgctgccctg gccgcagagg accccatccg   3240

cagccactcc ttccggaaca cgatactggg ttactttgac tatgccttca cagccatctt   3300

tactgttgag atcctgttga agatgacaac ttttggagct ttcctccaca aaggggcctt   3360

ctgcaggaac tacttcaatt tgctggatat gctggtggtt ggggtgtctc tggtgtcatt   3420

tgggattcaa tccagtgcca tctccgttgt gaagattctg agggtcttaa gggtcctgcg   3480

tcccctcagg gccatcaaca gagcaaaagg acttaagcac gtggtccagt gcgtcttcgt   3540

ggccatccgg accatcggca acatcatgat cgtcaccacc ctcctgcagt tcatgtttgc   3600

ctgtatcggg gtccagttgt tcaaggggaa gttctatcgc tgtacggatg aagccaaaag   3660

taaccctgaa gaatgcaggg gacttttcat cctctacaag gatggggatg ttgacagtcc   3720

tgtggtccgt gaacggatct ggcaaaacag tgatttcaac ttcgacaacg tcctctctgc   3780

tatgatggcg ctcttcacag tctccacgtt tgagggctgg cctgcgttgc tgtataaagc   3840

catcgactcg aatggagaga acatcggccc aatctacaac caccgcgtgg agatctccat   3900

cttcttcatc atctacatca tcattgtagc tttcttcatg atgaacatct ttgtgggctt   3960

tgtcatcgtt acatttcagg aacaaggaga aaaagagtat aagaactgtg agctggacaa   4020

aaatcagcgt cagtgtgttg aatacgcctt gaaagcacgt cccttgcgga gatacatccc   4080

caaaaacccc taccagtaca agttctggta cgtggtgaac tcttcgcctt tcgaatacat   4140

gatgtttgtc ctcatcatgc tcaacacact ctgcttggcc atgcagcact acgagcagtc   4200

caagatgttc aatgatgcca tggacattct gaacatggtc ttcaccgggg tgttcaccgt   4260

cgagatggtt ttgaaagtca tcgcatttaa gcctaagggg tattttagtg acgcctggaa   4320

cacgtttgac tccctcatcg taatcggcag cattatagac gtggccctca gcgaagcaga   4380

cccaactgaa agtgaaaatg tccctgtccc aactgctaca cctgggaact ctgaagagag   4440

caatagaatc tccatcacct ttttccgtct tttccgagtg atgcgattgg tgaagcttct   4500

cagcaggggg gaaggcatcc ggacattgct gtggactttt attaagtcct ttcaggcgct   4560

cccgtatgtg gccctcctca tagccatgct gttcttcatc tatgcggtca ttggcatgca   4620

gatgtttggg aaagttgcca tgagagataa caaccagatc aataggaaca ataacttcca   4680

gacgtttccc caggcggtgc tgctgctctt caggtgtgca acaggtgagg cctggcagga   4740

gatcatgctg gcctgtctcc cagggaagct ctgtgaccct gagtcagatt acaaccccgg   4800

ggaggagtat acatgtggga gcaactttgc cattgtctat ttcatcagtt tttacatgct   4860

ctgtgcattt ctgatcatca atctgtttgt ggctgtcatc atggataatt tcgactatct   4920

gacccgggac tggtctattt tggggcctca ccatttagat gaattcaaaa gaatatggtc   4980

agaatatgac cctgaggcaa agggaaggat aaaacacctt gatgtggtca ctctgcttcg   5040

acgcatccag cctcccctgg ggtttgggaa gttatgtcca cacagggtag cgtgcaagag   5100

attagttgcc atgaacatgc ctctcaacag tgacgggaca gtcatgttta atgcaaccct   5160

gtttgctttg gttcgaacgg ctcttaagat caagaccgaa gggaacctgg agcaagctaa   5220

tgaagaactt cgggctgtga taaagaaaat ttggaagaaa accagcatga aattacttga   5280

ccaagttgtc cctccagctg gtgatgatga ggtaaccgtg gggaagttct atgccacttt   5340

cctgatacag gactacttta ggaaattcaa gaaacggaaa gaacaaggac tggtgggaaa   5400

gtaccctgcg aagaacacca caattgccct acaggcggga ttaaggacac tgcatgacat   5460

tgggccagaa atccggcgtg ctatatcgtg tgatttgcaa gatgacgagc ctgaggaaac   5520

aaaacgagaa gaagaagatg atgtgttcaa aagaaatggt gccctgcttg gaaaccatgt   5580

caatcatgtt aatagtgata ggagagattc ccttcagcag accaatacca cccaccgtcc   5640

cctgcatgtc caaaggcctt caattccacc tgcaagtgat actgagaaac cgctgtttcc   5700

tccagcagga aattcggtgt gtcataacca tcataaccat aattccatag gaaagcaagt   5760

tcccacctca acaaatgcca atctcaataa tgccaatatg tccaaagctg cccatggaaa   5820

gcggcccagc attgggaacc ttgagcatgt gtctgaaaat gggcatcatt cttcccacaa   5880

gcatgaccgg gagcctcaga gaaggtccag tgtgaaaaga acccgctatt atgaaactta   5940

cattaggtcc gactcaggag atgaacagct cccaactatt tgccgggaag acccagagat   6000

acatggctat ttcagggacc cccactgctt gggggagcag gagtatttca gtagtgagga   6060

atgctacgag gatgacagct cgcccacctg gagcaggcaa aactatggct actacagcag   6120

atacccaggc agaaacatcg actctgagag gccccgaggc taccatcatc cccaaggatt   6180

cttggaggac gatgactcgc ccgtttgcta tgattcacgg agatctccaa ggagacgcct   6240

actacctccc accccagcat cccaccggag atcctccttc aactttgagt gcctgcgccg   6300

gcagagcagc caggaagagg tcccgtcgtc tcccatcttc ccccatcgca cggccctgcc   6360

tctgcatcta atgcagcaac agatcatggc agttgccggc ctagattcaa gtaaagccca   6420

gaagtactca ccgagtcact cgacccggtc gtgggccacc cctccagcaa cccctcccta   6480

ccgggactgg acaccgtgct acacccccct gatccaagtg gagcagtcag aggccctgga   6540

ccaggtgaac ggcagcctgc cgtccctgca ccgcagctcc tggtacacag acgagcccga   6600

catctcctac cggactttca caccagccag cctgactgtc cccagcagct tccggaacaa   6660

aaacagcgac aagcagagga gtgcggacag cttggtggag gcagtcctga tatccgaagg   6720

cttgggacgc tatgcaaggg acccaaaatt tgtgtcagca acaaaacacg aaatcgctga   6780

tgcctgtgac ctcaccatcg acgagatgga gagtgcagcc agcaccctgc ttaatgggaa   6840

cgtgcgtccc cgagccaacg gggatgtggg ccccctctca caccggcagg actatgagct   6900

acaggacttt ggtcctggct acagcgacga agagccagac cctgggaggg atgaggagga   6960

cctggcggat gaaatgatat gcatcaccac cttgtagccc ccagcgaggg gcagactggc   7020

tctggcctca ggtggggcgc aggagagcca ggggaaaagt gcctcatagt taggaaagtt   7080

taggcactag ttgggagtaa tattcaatta attagacttt tgtataagag atgtcatgcc   7140

tcaagaaagc cataaacctg gtaggaacag gtcccaagcg gttgagcctg gcagagtacc   7200

atgcgctcgg ccccagctgc aggaaacagc aggccccgcc ctctcacaga ggatgggtga   7260

ggaggccaga cctgccctgc cccattgtcc agatgggcac tgctgtggag tctgcttctc   7320

ccatgtacca gggcaccagg cccacccaac tgaaggcatg gcggcggggt gcaggggaaa   7380

gttaaaggtg atgacgatca tcacacctgt gtcgttacct cagccatcgg tctagcatat   7440

cagtcactgg gcccaacata tccattttta aaccctttcc cccaaataca ctgcgtcctg   7500

gttcctgttt agctgttctg aaatacggtg tgtaagtaag tcagaaccca gctaccagtg   7560

attattgcga gggcaatggg acctcataaa taaggttttc tgtgatgtga cgccagttta   7620

cataagagaa tatcactccg atggtcggtt tctgactgtc acgctaaggg caactgtaaa   7680

ctggaataat aatgcactcg caaccaggta aacttagata cactagtttg tttaaaatta   7740

tagatttact gtacatgact tgtaatatac tataatttgt atttgtaaag agatggtcta   7800

tattttgtaa ttactgtatt gtatttgaac tgcagcaata tccatgggtc ctaataattg   7860

tagttcccca ctaaaatcta gaaattatta gtatttttac tcgggctatc cagaagtaga   7920

agaaatagag ccaattctca tttattcagc gaaaatcctc tggggttaaa attttaagtt   7980

tgaaagaact tgacactaca gaaatttttc taaaatattt tgagtcacta taaacctatc   8040

atctttccac aag                                                      8053


<210>  2251
<211>  2161
<212>  PRT
<213>  Homo sapiens

<400>  2251

Met Met Met Met Met Met Met Lys Lys Met Gln His Gln Arg Gln Gln 
1               5                   10                  15


Gln Ala Asp His Ala Asn Glu Ala Asn Tyr Ala Arg Gly Thr Arg Leu 
            20                  25                  30


Pro Leu Ser Gly Glu Gly Pro Thr Ser Gln Pro Asn Ser Ser Lys Gln 
        35                  40                  45


Thr Val Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys 
    50                  55                  60


Ala Ala Gln Thr Met Ser Thr Ser Ala Pro Pro Pro Val Gly Ser Leu 
65                  70                  75                  80


Ser Gln Arg Lys Arg Gln Gln Tyr Ala Lys Ser Lys Lys Gln Gly Asn 
                85                  90                  95


Ser Ser Asn Ser Arg Pro Ala Arg Ala Leu Phe Cys Leu Ser Leu Asn 
            100                 105                 110


Asn Pro Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe 
        115                 120                 125


Asp Ile Phe Ile Leu Leu Ala Ile Phe Ala Asn Cys Val Ala Leu Ala 
    130                 135                 140


Ile Tyr Ile Pro Phe Pro Glu Asp Asp Ser Asn Ser Thr Asn His Asn 
145                 150                 155                 160


Leu Glu Lys Val Glu Tyr Ala Phe Leu Ile Ile Phe Thr Val Glu Thr 
                165                 170                 175


Phe Leu Lys Ile Ile Ala Tyr Gly Leu Leu Leu His Pro Asn Ala Tyr 
            180                 185                 190


Val Arg Asn Gly Trp Asn Leu Leu Asp Phe Val Ile Val Ile Val Gly 
        195                 200                 205


Leu Phe Ser Val Ile Leu Glu Gln Leu Thr Lys Glu Thr Glu Gly Gly 
    210                 215                 220


Asn His Ser Ser Gly Lys Ser Gly Gly Phe Asp Val Lys Ala Leu Arg 
225                 230                 235                 240


Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser 
                245                 250                 255


Leu Gln Val Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu 
            260                 265                 270


His Ile Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile 
        275                 280                 285


Gly Leu Glu Leu Phe Ile Gly Lys Met His Lys Thr Cys Phe Phe Ala 
    290                 295                 300


Asp Ser Asp Ile Val Ala Glu Glu Asp Pro Ala Pro Cys Ala Phe Ser 
305                 310                 315                 320


Gly Asn Gly Arg Gln Cys Thr Ala Asn Gly Thr Glu Cys Arg Ser Gly 
                325                 330                 335


Trp Val Gly Pro Asn Gly Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe 
            340                 345                 350


Ala Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp 
        355                 360                 365


Val Leu Tyr Trp Met Asn Asp Ala Met Gly Phe Glu Leu Pro Trp Val 
    370                 375                 380


Tyr Phe Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu 
385                 390                 395                 400


Val Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala 
                405                 410                 415


Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu 
            420                 425                 430


Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile 
        435                 440                 445


Asp Pro Glu Asn Glu Glu Glu Gly Gly Glu Glu Gly Lys Arg Asn Thr 
    450                 455                 460


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ser 
465                 470                 475                 480


Gly Glu Gly Glu Asn Arg Gly Cys Cys Gly Ser Leu Cys Gln Ala Ile 
                485                 490                 495


Ser Lys Ser Lys Leu Ser Arg Arg Trp Arg Arg Trp Asn Arg Phe Asn 
            500                 505                 510


Arg Arg Arg Cys Arg Ala Ala Val Lys Ser Val Thr Phe Tyr Trp Leu 
        515                 520                 525


Val Ile Val Leu Val Phe Leu Asn Thr Leu Thr Ile Ser Ser Glu His 
    530                 535                 540


Tyr Asn Gln Pro Asp Trp Leu Thr Gln Ile Gln Asp Ile Ala Asn Lys 
545                 550                 555                 560


Val Leu Leu Ala Leu Phe Thr Cys Glu Met Leu Val Lys Met Tyr Ser 
                565                 570                 575


Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp Cys 
            580                 585                 590


Phe Val Val Cys Gly Gly Ile Thr Glu Thr Ile Leu Val Glu Leu Glu 
        595                 600                 605


Ile Met Ser Pro Leu Gly Ile Ser Val Phe Arg Cys Val Arg Leu Leu 
    610                 615                 620


Arg Ile Phe Lys Val Thr Arg His Trp Thr Ser Leu Ser Asn Leu Val 
625                 630                 635                 640


Ala Ser Leu Leu Asn Ser Met Lys Ser Ile Ala Ser Leu Leu Leu Leu 
                645                 650                 655


Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu Phe 
            660                 665                 670


Gly Gly Lys Phe Asn Phe Asp Glu Thr Gln Thr Lys Arg Ser Thr Phe 
        675                 680                 685


Asp Asn Phe Pro Gln Ala Leu Leu Thr Val Phe Gln Ile Leu Thr Gly 
    690                 695                 700


Glu Asp Trp Asn Ala Val Met Tyr Asp Gly Ile Met Ala Tyr Gly Gly 
705                 710                 715                 720


Pro Ser Ser Ser Gly Met Ile Val Cys Ile Tyr Phe Ile Ile Leu Phe 
                725                 730                 735


Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala Val 
            740                 745                 750


Asp Asn Leu Ala Asp Ala Glu Ser Leu Asn Thr Ala Gln Lys Glu Glu 
        755                 760                 765


Ala Glu Glu Lys Glu Arg Lys Lys Ile Ala Arg Lys Glu Ser Leu Glu 
    770                 775                 780


Asn Lys Lys Asn Asn Lys Pro Glu Val Asn Gln Ile Ala Asn Ser Asp 
785                 790                 795                 800


Asn Lys Val Thr Ile Asp Asp Tyr Arg Glu Glu Asp Glu Asp Lys Asp 
                805                 810                 815


Pro Tyr Pro Pro Cys Asp Val Pro Val Gly Glu Glu Glu Glu Glu Glu 
            820                 825                 830


Glu Glu Asp Glu Pro Glu Val Pro Ala Gly Pro Arg Pro Arg Arg Ile 
        835                 840                 845


Ser Glu Leu Asn Met Lys Glu Lys Ile Ala Pro Ile Pro Glu Gly Ser 
    850                 855                 860


Ala Phe Phe Ile Leu Ser Lys Thr Asn Pro Ile Arg Val Gly Cys His 
865                 870                 875                 880


Lys Leu Ile Asn His His Ile Phe Thr Asn Leu Ile Leu Val Phe Ile 
                885                 890                 895


Met Leu Ser Ser Ala Ala Leu Ala Ala Glu Asp Pro Ile Arg Ser His 
            900                 905                 910


Ser Phe Arg Asn Thr Ile Leu Gly Tyr Phe Asp Tyr Ala Phe Thr Ala 
        915                 920                 925


Ile Phe Thr Val Glu Ile Leu Leu Lys Met Thr Thr Phe Gly Ala Phe 
    930                 935                 940


Leu His Lys Gly Ala Phe Cys Arg Asn Tyr Phe Asn Leu Leu Asp Met 
945                 950                 955                 960


Leu Val Val Gly Val Ser Leu Val Ser Phe Gly Ile Gln Ser Ser Ala 
                965                 970                 975


Ile Ser Val Val Lys Ile Leu Arg Val Leu Arg Val Leu Arg Pro Leu 
            980                 985                 990


Arg Ala Ile Asn Arg Ala Lys Gly Leu Lys His Val Val Gln Cys Val 
        995                 1000                1005


Phe Val Ala Ile Arg Thr Ile Gly Asn Ile Met Ile Val Thr Thr Leu 
    1010                1015                1020


Leu Gln Phe Met Phe Ala Cys Ile Gly Val Gln Leu Phe Lys Gly Lys 
1025                1030                1035                1040


Phe Tyr Arg Cys Thr Asp Glu Ala Lys Ser Asn Pro Glu Glu Cys Arg 
                1045                1050                1055


Gly Leu Phe Ile Leu Tyr Lys Asp Gly Asp Val Asp Ser Pro Val Val 
            1060                1065                1070


Arg Glu Arg Ile Trp Gln Asn Ser Asp Phe Asn Phe Asp Asn Val Leu 
        1075                1080                1085


Ser Ala Met Met Ala Leu Phe Thr Val Ser Thr Phe Glu Gly Trp Pro 
    1090                1095                1100


Ala Leu Leu Tyr Lys Ala Ile Asp Ser Asn Gly Glu Asn Ile Gly Pro 
1105                1110                1115                1120


Ile Tyr Asn His Arg Val Glu Ile Ser Ile Phe Phe Ile Ile Tyr Ile 
                1125                1130                1135


Ile Ile Val Ala Phe Phe Met Met Asn Ile Phe Val Gly Phe Val Ile 
            1140                1145                1150


Val Thr Phe Gln Glu Gln Gly Glu Lys Glu Tyr Lys Asn Cys Glu Leu 
        1155                1160                1165


Asp Lys Asn Gln Arg Gln Cys Val Glu Tyr Ala Leu Lys Ala Arg Pro 
    1170                1175                1180


Leu Arg Arg Tyr Ile Pro Lys Asn Pro Tyr Gln Tyr Lys Phe Trp Tyr 
1185                1190                1195                1200


Val Val Asn Ser Ser Pro Phe Glu Tyr Met Met Phe Val Leu Ile Met 
                1205                1210                1215


Leu Asn Thr Leu Cys Leu Ala Met Gln His Tyr Glu Gln Ser Lys Met 
            1220                1225                1230


Phe Asn Asp Ala Met Asp Ile Leu Asn Met Val Phe Thr Gly Val Phe 
        1235                1240                1245


Thr Val Glu Met Val Leu Lys Val Ile Ala Phe Lys Pro Lys Gly Tyr 
    1250                1255                1260


Phe Ser Asp Ala Trp Asn Thr Phe Asp Ser Leu Ile Val Ile Gly Ser 
1265                1270                1275                1280


Ile Ile Asp Val Ala Leu Ser Glu Ala Asp Pro Thr Glu Ser Glu Asn 
                1285                1290                1295


Val Pro Val Pro Thr Ala Thr Pro Gly Asn Ser Glu Glu Ser Asn Arg 
            1300                1305                1310


Ile Ser Ile Thr Phe Phe Arg Leu Phe Arg Val Met Arg Leu Val Lys 
        1315                1320                1325


Leu Leu Ser Arg Gly Glu Gly Ile Arg Thr Leu Leu Trp Thr Phe Ile 
    1330                1335                1340


Lys Ser Phe Gln Ala Leu Pro Tyr Val Ala Leu Leu Ile Ala Met Leu 
1345                1350                1355                1360


Phe Phe Ile Tyr Ala Val Ile Gly Met Gln Met Phe Gly Lys Val Ala 
                1365                1370                1375


Met Arg Asp Asn Asn Gln Ile Asn Arg Asn Asn Asn Phe Gln Thr Phe 
            1380                1385                1390


Pro Gln Ala Val Leu Leu Leu Phe Arg Cys Ala Thr Gly Glu Ala Trp 
        1395                1400                1405


Gln Glu Ile Met Leu Ala Cys Leu Pro Gly Lys Leu Cys Asp Pro Glu 
    1410                1415                1420


Ser Asp Tyr Asn Pro Gly Glu Glu Tyr Thr Cys Gly Ser Asn Phe Ala 
1425                1430                1435                1440


Ile Val Tyr Phe Ile Ser Phe Tyr Met Leu Cys Ala Phe Leu Ile Ile 
                1445                1450                1455


Asn Leu Phe Val Ala Val Ile Met Asp Asn Phe Asp Tyr Leu Thr Arg 
            1460                1465                1470


Asp Trp Ser Ile Leu Gly Pro His His Leu Asp Glu Phe Lys Arg Ile 
        1475                1480                1485


Trp Ser Glu Tyr Asp Pro Glu Ala Lys Gly Arg Ile Lys His Leu Asp 
    1490                1495                1500


Val Val Thr Leu Leu Arg Arg Ile Gln Pro Pro Leu Gly Phe Gly Lys 
1505                1510                1515                1520


Leu Cys Pro His Arg Val Ala Cys Lys Arg Leu Val Ala Met Asn Met 
                1525                1530                1535


Pro Leu Asn Ser Asp Gly Thr Val Met Phe Asn Ala Thr Leu Phe Ala 
            1540                1545                1550


Leu Val Arg Thr Ala Leu Lys Ile Lys Thr Glu Gly Asn Leu Glu Gln 
        1555                1560                1565


Ala Asn Glu Glu Leu Arg Ala Val Ile Lys Lys Ile Trp Lys Lys Thr 
    1570                1575                1580


Ser Met Lys Leu Leu Asp Gln Val Val Pro Pro Ala Gly Asp Asp Glu 
1585                1590                1595                1600


Val Thr Val Gly Lys Phe Tyr Ala Thr Phe Leu Ile Gln Asp Tyr Phe 
                1605                1610                1615


Arg Lys Phe Lys Lys Arg Lys Glu Gln Gly Leu Val Gly Lys Tyr Pro 
            1620                1625                1630


Ala Lys Asn Thr Thr Ile Ala Leu Gln Ala Gly Leu Arg Thr Leu His 
        1635                1640                1645


Asp Ile Gly Pro Glu Ile Arg Arg Ala Ile Ser Cys Asp Leu Gln Asp 
    1650                1655                1660


Asp Glu Pro Glu Glu Thr Lys Arg Glu Glu Glu Asp Asp Val Phe Lys 
1665                1670                1675                1680


Arg Asn Gly Ala Leu Leu Gly Asn His Val Asn His Val Asn Ser Asp 
                1685                1690                1695


Arg Arg Asp Ser Leu Gln Gln Thr Asn Thr Thr His Arg Pro Leu His 
            1700                1705                1710


Val Gln Arg Pro Ser Ile Pro Pro Ala Ser Asp Thr Glu Lys Pro Leu 
        1715                1720                1725


Phe Pro Pro Ala Gly Asn Ser Val Cys His Asn His His Asn His Asn 
    1730                1735                1740


Ser Ile Gly Lys Gln Val Pro Thr Ser Thr Asn Ala Asn Leu Asn Asn 
1745                1750                1755                1760


Ala Asn Met Ser Lys Ala Ala His Gly Lys Arg Pro Ser Ile Gly Asn 
                1765                1770                1775


Leu Glu His Val Ser Glu Asn Gly His His Ser Ser His Lys His Asp 
            1780                1785                1790


Arg Glu Pro Gln Arg Arg Ser Ser Val Lys Arg Thr Arg Tyr Tyr Glu 
        1795                1800                1805


Thr Tyr Ile Arg Ser Asp Ser Gly Asp Glu Gln Leu Pro Thr Ile Cys 
    1810                1815                1820


Arg Glu Asp Pro Glu Ile His Gly Tyr Phe Arg Asp Pro His Cys Leu 
1825                1830                1835                1840


Gly Glu Gln Glu Tyr Phe Ser Ser Glu Glu Cys Tyr Glu Asp Asp Ser 
                1845                1850                1855


Ser Pro Thr Trp Ser Arg Gln Asn Tyr Gly Tyr Tyr Ser Arg Tyr Pro 
            1860                1865                1870


Gly Arg Asn Ile Asp Ser Glu Arg Pro Arg Gly Tyr His His Pro Gln 
        1875                1880                1885


Gly Phe Leu Glu Asp Asp Asp Ser Pro Val Cys Tyr Asp Ser Arg Arg 
    1890                1895                1900


Ser Pro Arg Arg Arg Leu Leu Pro Pro Thr Pro Ala Ser His Arg Arg 
1905                1910                1915                1920


Ser Ser Phe Asn Phe Glu Cys Leu Arg Arg Gln Ser Ser Gln Glu Glu 
                1925                1930                1935


Val Pro Ser Ser Pro Ile Phe Pro His Arg Thr Ala Leu Pro Leu His 
            1940                1945                1950


Leu Met Gln Gln Gln Ile Met Ala Val Ala Gly Leu Asp Ser Ser Lys 
        1955                1960                1965


Ala Gln Lys Tyr Ser Pro Ser His Ser Thr Arg Ser Trp Ala Thr Pro 
    1970                1975                1980


Pro Ala Thr Pro Pro Tyr Arg Asp Trp Thr Pro Cys Tyr Thr Pro Leu 
1985                1990                1995                2000


Ile Gln Val Glu Gln Ser Glu Ala Leu Asp Gln Val Asn Gly Ser Leu 
                2005                2010                2015


Pro Ser Leu His Arg Ser Ser Trp Tyr Thr Asp Glu Pro Asp Ile Ser 
            2020                2025                2030


Tyr Arg Thr Phe Thr Pro Ala Ser Leu Thr Val Pro Ser Ser Phe Arg 
        2035                2040                2045


Asn Lys Asn Ser Asp Lys Gln Arg Ser Ala Asp Ser Leu Val Glu Ala 
    2050                2055                2060


Val Leu Ile Ser Glu Gly Leu Gly Arg Tyr Ala Arg Asp Pro Lys Phe 
2065                2070                2075                2080


Val Ser Ala Thr Lys His Glu Ile Ala Asp Ala Cys Asp Leu Thr Ile 
                2085                2090                2095


Asp Glu Met Glu Ser Ala Ala Ser Thr Leu Leu Asn Gly Asn Val Arg 
            2100                2105                2110


Pro Arg Ala Asn Gly Asp Val Gly Pro Leu Ser His Arg Gln Asp Tyr 
        2115                2120                2125


Glu Leu Gln Asp Phe Gly Pro Gly Tyr Ser Asp Glu Glu Pro Asp Pro 
    2130                2135                2140


Gly Arg Asp Glu Glu Asp Leu Ala Asp Glu Met Ile Cys Ile Thr Thr 
2145                2150                2155                2160


Leu 



<210>  2252
<211>  9319
<212>  DNA
<213>  Homo sapiens

<400>  2252
gggcgagcgc ctccgtcccc ggatgtgagc tccggctgcc cgcggtcccg agccagcggc     60

ggcgcgggcg gcggcggcgg gcaccgggca ccgcggcggg cgggcagacg ggcgggcatg    120

gggggagcgc cgagcggccc cggcggccgg gccggcatca ccgcggcgtc tctccgctag    180

aggaggggac aagccagttc tcctttgcag caaaaaatta catgtatata ttattaagat    240

aatatataca ttggatttta tttttttaaa aagtttattt tgctccattt ttgaaaaaga    300

gagagcttgg gtggcgagcg gttttttttt taaatcaatt atccttattt tctgttattt    360

gtccccgtcc ctccccaccc ccctgctgaa gcgagaataa gggcagggac cgcggctcct    420

acctcttggt gatccccttc cccattccgc ccccgcctca acgcccagca cagtgccctg    480

cacacagtag tcgctcaata aatgttcgtg gatgatgatg atgatgatga tgaaaaaaat    540

gcagcatcaa cggcagcagc aagcggacca cgcgaacgag gcaaactatg caagaggcac    600

cagacttcct ctttctggtg aaggaccaac ttctcagccg aatagctcca agcaaactgt    660

cctgtcttgg caagctgcaa tcgatgctgc tagacaggcc aaggctgccc aaactatgag    720

cacctctgca cccccacctg taggatctct ctcccaaaga aaacgtcagc aatacgccaa    780

gagcaaaaaa cagggtaact cgtccaacag ccgacctgcc cgcgcccttt tctgtttatc    840

actcaataac cccatccgaa gagcctgcat tagtatagtg gaatggaaac catttgacat    900

atttatatta ttggctattt ttgccaattg tgtggcctta gctatttaca tcccattccc    960

tgaagatgat tctaattcaa caaatcataa cttggaaaaa gtagaatatg ccttcctgat   1020

tatttttaca gtcgagacat ttttgaagat tatagcgtat ggattattgc tacatcctaa   1080

tgcttatgtt aggaatggat ggaatttact ggattttgtt atagtaatag taggattgtt   1140

tagtgtaatt ttggaacaat taaccaaaga aacagaaggc gggaaccact caagcggcaa   1200

atctggaggc tttgatgtca aagccctccg tgcctttcga gtgttgcgac cacttcgact   1260

agtgtcagga gtgcccagtt tacaagttgt cctgaactcc attataaaag ccatggttcc   1320

cctccttcac atagcccttt tggtattatt tgtaatcata atctatgcta ttataggatt   1380

ggaacttttt attggaaaaa tgcacaaaac atgttttttt gctgactcag atatcgtagc   1440

tgaagaggac ccagctccat gtgcgttctc agggaatgga cgccagtgta ctgccaatgg   1500

cacggaatgt aggagtggct gggttggccc gaacggaggc atcaccaact ttgataactt   1560

tgcctttgcc atgcttactg tgtttcagtg catcaccatg gagggctgga cagatgtgct   1620

ctactggatg aatgatgcta tgggatttga attgccctgg gtgtattttg tcagtctcgt   1680

catctttggg tcatttttcg tactaaatct tgtacttggt gtattgagcg gagaattctc   1740

aaaggaaaga gagaaggcaa aagcacgggg agatttccag aagctccggg agaagcagca   1800

gctggaggag gatctaaagg gctacttgga ttggatcacc caagctgagg acatcgatcc   1860

ggagaatgag gaagaaggag gagaggaagg caaacgaaat actagcatgc ccaccagcga   1920

gactgagtct gtgaacacag agaacgtcag cggtgaaggc gagaaccgag gctgctgtgg   1980

aagtctctgt caagccatct caaaatccaa actcagccga cgctggcgtc gctggaaccg   2040

attcaatcgc agaagatgta gggccgccgt gaagtctgtc acgttttact ggctggttat   2100

cgtcctggtg tttctgaaca ccttaaccat ttcctctgag cactacaatc agccagattg   2160

gttgacacag attcaagata ttgccaacaa agtcctcttg gctctgttca cctgcgagat   2220

gctggtaaaa atgtacagct tgggcctcca agcatatttc gtctctcttt tcaaccggtt   2280

tgattgcttc gtggtgtgtg gtggaatcac tgagacgatc ttggtggaac tggaaatcat   2340

gtctcccctg gggatctctg tgtttcggtg tgtgcgcctc ttaagaatct tcaaagtgac   2400

caggcactgg acttccctga gcaacttagt ggcatcctta ttaaactcca tgaagtccat   2460

cgcttcgctg ttgcttctgc tttttctctt cattatcatc ttttccttgc ttgggatgca   2520

gctgtttggc ggcaagttta attttgatga aacgcaaacc aagcggagca cctttgacaa   2580

tttccctcaa gcacttctca cagtgttcca gatcctgaca ggcgaagact ggaatgctgt   2640

gatgtacgat ggcatcatgg cttacggggg cccatcctct tcaggaatga tcgtctgcat   2700

ctacttcatc atcctcttca tttgtggtaa ctatattcta ctgaatgtct tcttggccat   2760

cgctgtagac aatttggctg atgctgaaag tctgaacact gctcagaaag aagaagcgga   2820

agaaaaggag aggaaaaaga ttgccagaaa agagagccta gaaaataaaa agaacaacaa   2880

accagaagtc aaccagatag ccaacagtga caacaaggtt acaattgatg actatagaga   2940

agaggatgaa gacaaggacc cctatccgcc ttgcgatgtg ccagtagggg aagaggaaga   3000

ggaagaggag gaggatgaac ctgaggttcc tgccggaccc cgtcctcgaa ggatctcgga   3060

gttgaacatg aaggaaaaaa ttgcccccat ccctgaaggg agcgctttct tcattcttag   3120

caagaccaac ccgatccgcg taggctgcca caagctcatc aaccaccaca tcttcaccaa   3180

cctcatcctt gtcttcatca tgctgagcag cgctgccctg gccgcagagg accccatccg   3240

cagccactcc ttccggaaca cgatactggg ttactttgac tatgccttca cagccatctt   3300

tactgttgag atcctgttga agatgacaac ttttggagct ttcctccaca aaggggcctt   3360

ctgcaggaac tacttcaatt tgctggatat gctggtggtt ggggtgtctc tggtgtcatt   3420

tgggattcaa tccagtgcca tctccgttgt gaagattctg agggtcttaa gggtcctgcg   3480

tcccctcagg gccatcaaca gagcaaaagg acttaagcac gtggtccagt gcgtcttcgt   3540

ggccatccgg accatcggca acatcatgat cgtcaccacc ctcctgcagt tcatgtttgc   3600

ctgtatcggg gtccagttgt tcaaggggaa gttctatcgc tgtacggatg aagccaaaag   3660

taaccctgaa gaatgcaggg gacttttcat cctctacaag gatggggatg ttgacagtcc   3720

tgtggtccgt gaacggatct ggcaaaacag tgatttcaac ttcgacaacg tcctctctgc   3780

tatgatggcg ctcttcacag tctccacgtt tgagggctgg cctgcgttgc tgtataaagc   3840

catcgactcg aatggagaga acatcggccc aatctacaac caccgcgtgg agatctccat   3900

cttcttcatc atctacatca tcattgtagc tttcttcatg atgaacatct ttgtgggctt   3960

tgtcatcgtt acatttcagg aacaaggaga aaaagagtat aagaactgtg agctggacaa   4020

aaatcagcgt cagtgtgttg aatacgcctt gaaagcacgt cccttgcgga gatacatccc   4080

caaaaacccc taccagtaca agttctggta cgtggtgaac tcttcgcctt tcgaatacat   4140

gatgtttgtc ctcatcatgc tcaacacact ctgcttggcc atgcagcact acgagcagtc   4200

caagatgttc aatgatgcca tggacattct gaacatggtc ttcaccgggg tgttcaccgt   4260

cgagatggtt ttgaaagtca tcgcatttaa gcctaagggg tattttagtg acgcctggaa   4320

cacgtttgac tccctcatcg taatcggcag cattatagac gtggccctca gcgaagcaga   4380

cccaactgaa agtgaaaatg tccctgtccc aactgctaca cctgggaact ctgaagagag   4440

caatagaatc tccatcacct ttttccgtct tttccgagtg atgcgattgg tgaagcttct   4500

cagcaggggg gaaggcatcc ggacattgct gtggactttt attaagtcct ttcaggcgct   4560

cccgtatgtg gccctcctca tagccatgct gttcttcatc tatgcggtca ttggcatgca   4620

gatgtttggg aaagttgcca tgagagataa caaccagatc aataggaaca ataacttcca   4680

gacgtttccc caggcggtgc tgctgctctt caggtgtgca acaggtgagg cctggcagga   4740

gatcatgctg gcctgtctcc cagggaagct ctgtgaccct gagtcagatt acaaccccgg   4800

ggaggagtat acatgtggga gcaactttgc cattgtctat ttcatcagtt tttacatgct   4860

ctgtgcattt ctgatcatca atctgtttgt ggctgtcatc atggataatt tcgactatct   4920

gacccgggac tggtctattt tggggcctca ccatttagat gaattcaaaa gaatatggtc   4980

agaatatgac cctgaggcaa agggaaggat aaaacacctt gatgtggtca ctctgcttcg   5040

acgcatccag cctcccctgg ggtttgggaa gttatgtcca cacagggtag cgtgcaagag   5100

attagttgcc atgaacatgc ctctcaacag tgacgggaca gtcatgttta atgcaaccct   5160

gtttgctttg gttcgaacgg ctcttaagat caagaccgaa gggaacctgg agcaagctaa   5220

tgaagaactt cgggctgtga taaagaaaat ttggaagaaa accagcatga aattacttga   5280

ccaagttgtc cctccagctg gtgatgatga ggtaaccgtg gggaagttct atgccacttt   5340

cctgatacag gactacttta ggaaattcaa gaaacggaaa gaacaaggac tggtgggaaa   5400

gtaccctgcg aagaacacca caattgccct acaggcggga ttaaggacac tgcatgacat   5460

tgggccagaa atccggcgtg ctatatcgtg tgatttgcaa gatgacgagc ctgaggaaac   5520

aaaacgagaa gaagaagatg atgtgttcaa aagaaatggt gccctgcttg gaaaccatgt   5580

caatcatgtt aatagtgata ggagagattc ccttcagcag accaatacca cccaccgtcc   5640

cctgcatgtc caaaggcctt caattccacc tgcaagtgat actgagaaac cgctgtttcc   5700

tccagcagga aattcggtgt gtcataacca tcataaccat aattccatag gaaagcaagt   5760

tcccacctca acaaatgcca atctcaataa tgccaatatg tccaaagctg cccatggaaa   5820

gcggcccagc attgggaacc ttgagcatgt gtctgaaaat gggcatcatt cttcccacaa   5880

gcatgaccgg gagcctcaga gaaggtccag tgtgaaaaga acccgctatt atgaaactta   5940

cattaggtcc gactcaggag atgaacagct cccaactatt tgccgggaag acccagagat   6000

acatggctat ttcagggacc cccactgctt gggggagcag gagtatttca gtagtgagga   6060

atgctacgag gatgacagct cgcccacctg gagcaggcaa aactatggct actacagcag   6120

atacccaggc agaaacatcg actctgagag gccccgaggc taccatcatc cccaaggatt   6180

cttggaggac gatgactcgc ccgtttgcta tgattcacgg agatctccaa ggagacgcct   6240

actacctccc accccagcat cccaccggag atcctccttc aactttgagt gcctgcgccg   6300

gcagagcagc caggaagagg tcccgtcgtc tcccatcttc ccccatcgca cggccctgcc   6360

tctgcatcta atgcagcaac agatcatggc agttgccggc ctagattcaa gtaaagccca   6420

gaagtactca ccgagtcact cgacccggtc gtgggccacc cctccagcaa cccctcccta   6480

ccgggactgg acaccgtgct acacccccct gatccaagtg gagcagtcag aggccctgga   6540

ccaggtgaac ggcagcctgc cgtccctgca ccgcagctcc tggtacacag acgagcccga   6600

catctcctac cggactttca caccagccag cctgactgtc cccagcagct tccggaacaa   6660

aaacagcgac aagcagagga gtgcggacag cttggtggag gcagtcctga tatccgaagg   6720

cttgggacgc tatgcaaggg acccaaaatt tgtgtcagca acaaaacacg aaatcgctga   6780

tgcctgtgac ctcaccatcg acgagatgga gagtgcagcc agcaccctgc ttaatgggaa   6840

cgtgcgtccc cgagccaacg gggatgtggg ccccctctca caccggcagg actatgagct   6900

acaggacttt ggtcctggct acagcgacga agagccagac cctgggaggg atgaggagga   6960

cctggcggat gaaatgatat gcatcaccac cttgtagccc ccagcgaggg gcagactggc   7020

tctggcctca ggtggggcgc aggagagcca ggggaaaagt gcctcatagt taggaaagtt   7080

taggcactag ttgggagtaa tattcaatta attagacttt tgtataagag atgtcatgcc   7140

tcaagaaagc cataaacctg gtaggaacag gtcccaagcg gttgagcctg gcagagtacc   7200

atgcgctcgg ccccagctgc aggaaacagc aggccccgcc ctctcacaga ggatgggtga   7260

ggaggccaga cctgccctgc cccattgtcc agatgggcac tgctgtggag tctgcttctc   7320

ccatgtacca gggcaccagg cccacccaac tgaaggcatg gcggcggggt gcaggggaaa   7380

gttaaaggtg atgacgatca tcacacctgt gtcgttacct cagccatcgg tctagcatat   7440

cagtcactgg gcccaacata tccattttta aaccctttcc cccaaataca ctgcgtcctg   7500

gttcctgttt agctgttctg aaatacggtg tgtaagtaag tcagaaccca gctaccagtg   7560

attattgcga gggcaatggg acctcataaa taaggttttc tgtgatgtga cgccagttta   7620

cataagagaa tatcactccg atggtcggtt tctgactgtc acgctaaggg caactgtaaa   7680

ctggaataat aatgcactcg caaccaggta aacttagata cactagtttg tttaaaatta   7740

tagatttact gtacatgact tgtaatatac tataatttgt atttgtaaag agatggtcta   7800

tattttgtaa ttactgtatt gtatttgaac tgcagcaata tccatgggtc ctaataattg   7860

tagttcccca ctaaaatcta gaaattatta gtatttttac tcgggctatc cagaagtaga   7920

agaaatagag ccaattctca tttattcagc gaaaatcctc tggggttaaa attttaagtt   7980

tgaaagaact tgacactaca gaaatttttc taaaatattt tgagtcacta taaacctatc   8040

atctttccac aagatatacc agatgactat ttgcagtctt ttctttgggc aagagttcca   8100

tgattttgat actgtacctt tggatccacc atgggttgca actgtctttg gttttgtttg   8160

tttgacttga accaccctct ggtaagtaag taagtgaatt acagagcagg tccagctggc   8220

tgctctgccc cttgggtatc catagttacg gttttctctg tggcccaccc agggtgtttt   8280

ttgcatcgct ggtgcagaaa tgcataggtg gatgagatat agctgctctt gtcctctggg   8340

gactggtggt gctgcttaag aaataagggg tgctggggac agaggagcaa cgtggtgatc   8400

tataggattg gagtgtcggg gtctgtacaa atcgtattgt tgccttttac aaaactgctg   8460

tactgtatgt tctctttgag ggcttttata tgcaattgaa tgagggctga agttttcatt   8520

agaatgcact cacactctga ctgtacgtcc tgatgaaaac ccacttttgg ataattagaa   8580

ccgtcaaggc ttcattttct gtcaacagaa ttaggccgac tgtcaggtta ccttggcagg   8640

gattccctgc aatcaaaaag atagatgata ggtagcaatt ttggtccaaa atttttaata   8700

gtatacagac aacctgttaa tttttttttt tttttttttt tttgtaaata acaaacacca   8760

ctttgttatg aagaccttac aaacctcttc ttaagacatt cttactctga tccaggcaaa   8820

aacacttcaa ggtttgtaaa tgactctttc ctgacataaa tcctttttta ttaaaatgca   8880

aaatgttctt cagaataaaa ctgtgtaata atttttatac ttgggagtgc tccttgcaca   8940

gagctgtcat ttgccagtga gagcctccga cagggcaggt actgtgccag ggcagctctg   9000

aaattatgga tattcttatc ctcctggttc cttcggtgcc aatggtaacc taataccagc   9060

cgcagggagc gccatttctc ctaaagggct acaccactgt caacattatc ctggactctg   9120

tgtctctctc tgttgggtct tgtggcatca catcaggcca aaattgccag accaggaccc   9180

taagtgtctg atagaggcga tgatcttttc caaagtcagt acttacaaac tggcattctt   9240

acaggctgca ccatttccta gtatgtctgc tttaagcctg gttcaacctc tcatcgaata   9300

ttaaattttt ctttgtaag                                                9319


<210>  2253
<211>  2161
<212>  PRT
<213>  Homo sapiens

<400>  2253

Met Met Met Met Met Met Met Lys Lys Met Gln His Gln Arg Gln Gln 
1               5                   10                  15


Gln Ala Asp His Ala Asn Glu Ala Asn Tyr Ala Arg Gly Thr Arg Leu 
            20                  25                  30


Pro Leu Ser Gly Glu Gly Pro Thr Ser Gln Pro Asn Ser Ser Lys Gln 
        35                  40                  45


Thr Val Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys 
    50                  55                  60


Ala Ala Gln Thr Met Ser Thr Ser Ala Pro Pro Pro Val Gly Ser Leu 
65                  70                  75                  80


Ser Gln Arg Lys Arg Gln Gln Tyr Ala Lys Ser Lys Lys Gln Gly Asn 
                85                  90                  95


Ser Ser Asn Ser Arg Pro Ala Arg Ala Leu Phe Cys Leu Ser Leu Asn 
            100                 105                 110


Asn Pro Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe 
        115                 120                 125


Asp Ile Phe Ile Leu Leu Ala Ile Phe Ala Asn Cys Val Ala Leu Ala 
    130                 135                 140


Ile Tyr Ile Pro Phe Pro Glu Asp Asp Ser Asn Ser Thr Asn His Asn 
145                 150                 155                 160


Leu Glu Lys Val Glu Tyr Ala Phe Leu Ile Ile Phe Thr Val Glu Thr 
                165                 170                 175


Phe Leu Lys Ile Ile Ala Tyr Gly Leu Leu Leu His Pro Asn Ala Tyr 
            180                 185                 190


Val Arg Asn Gly Trp Asn Leu Leu Asp Phe Val Ile Val Ile Val Gly 
        195                 200                 205


Leu Phe Ser Val Ile Leu Glu Gln Leu Thr Lys Glu Thr Glu Gly Gly 
    210                 215                 220


Asn His Ser Ser Gly Lys Ser Gly Gly Phe Asp Val Lys Ala Leu Arg 
225                 230                 235                 240


Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser 
                245                 250                 255


Leu Gln Val Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu 
            260                 265                 270


His Ile Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile 
        275                 280                 285


Gly Leu Glu Leu Phe Ile Gly Lys Met His Lys Thr Cys Phe Phe Ala 
    290                 295                 300


Asp Ser Asp Ile Val Ala Glu Glu Asp Pro Ala Pro Cys Ala Phe Ser 
305                 310                 315                 320


Gly Asn Gly Arg Gln Cys Thr Ala Asn Gly Thr Glu Cys Arg Ser Gly 
                325                 330                 335


Trp Val Gly Pro Asn Gly Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe 
            340                 345                 350


Ala Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp 
        355                 360                 365


Val Leu Tyr Trp Met Asn Asp Ala Met Gly Phe Glu Leu Pro Trp Val 
    370                 375                 380


Tyr Phe Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu 
385                 390                 395                 400


Val Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala 
                405                 410                 415


Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu 
            420                 425                 430


Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile 
        435                 440                 445


Asp Pro Glu Asn Glu Glu Glu Gly Gly Glu Glu Gly Lys Arg Asn Thr 
    450                 455                 460


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ser 
465                 470                 475                 480


Gly Glu Gly Glu Asn Arg Gly Cys Cys Gly Ser Leu Cys Gln Ala Ile 
                485                 490                 495


Ser Lys Ser Lys Leu Ser Arg Arg Trp Arg Arg Trp Asn Arg Phe Asn 
            500                 505                 510


Arg Arg Arg Cys Arg Ala Ala Val Lys Ser Val Thr Phe Tyr Trp Leu 
        515                 520                 525


Val Ile Val Leu Val Phe Leu Asn Thr Leu Thr Ile Ser Ser Glu His 
    530                 535                 540


Tyr Asn Gln Pro Asp Trp Leu Thr Gln Ile Gln Asp Ile Ala Asn Lys 
545                 550                 555                 560


Val Leu Leu Ala Leu Phe Thr Cys Glu Met Leu Val Lys Met Tyr Ser 
                565                 570                 575


Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp Cys 
            580                 585                 590


Phe Val Val Cys Gly Gly Ile Thr Glu Thr Ile Leu Val Glu Leu Glu 
        595                 600                 605


Ile Met Ser Pro Leu Gly Ile Ser Val Phe Arg Cys Val Arg Leu Leu 
    610                 615                 620


Arg Ile Phe Lys Val Thr Arg His Trp Thr Ser Leu Ser Asn Leu Val 
625                 630                 635                 640


Ala Ser Leu Leu Asn Ser Met Lys Ser Ile Ala Ser Leu Leu Leu Leu 
                645                 650                 655


Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu Phe 
            660                 665                 670


Gly Gly Lys Phe Asn Phe Asp Glu Thr Gln Thr Lys Arg Ser Thr Phe 
        675                 680                 685


Asp Asn Phe Pro Gln Ala Leu Leu Thr Val Phe Gln Ile Leu Thr Gly 
    690                 695                 700


Glu Asp Trp Asn Ala Val Met Tyr Asp Gly Ile Met Ala Tyr Gly Gly 
705                 710                 715                 720


Pro Ser Ser Ser Gly Met Ile Val Cys Ile Tyr Phe Ile Ile Leu Phe 
                725                 730                 735


Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala Val 
            740                 745                 750


Asp Asn Leu Ala Asp Ala Glu Ser Leu Asn Thr Ala Gln Lys Glu Glu 
        755                 760                 765


Ala Glu Glu Lys Glu Arg Lys Lys Ile Ala Arg Lys Glu Ser Leu Glu 
    770                 775                 780


Asn Lys Lys Asn Asn Lys Pro Glu Val Asn Gln Ile Ala Asn Ser Asp 
785                 790                 795                 800


Asn Lys Val Thr Ile Asp Asp Tyr Arg Glu Glu Asp Glu Asp Lys Asp 
                805                 810                 815


Pro Tyr Pro Pro Cys Asp Val Pro Val Gly Glu Glu Glu Glu Glu Glu 
            820                 825                 830


Glu Glu Asp Glu Pro Glu Val Pro Ala Gly Pro Arg Pro Arg Arg Ile 
        835                 840                 845


Ser Glu Leu Asn Met Lys Glu Lys Ile Ala Pro Ile Pro Glu Gly Ser 
    850                 855                 860


Ala Phe Phe Ile Leu Ser Lys Thr Asn Pro Ile Arg Val Gly Cys His 
865                 870                 875                 880


Lys Leu Ile Asn His His Ile Phe Thr Asn Leu Ile Leu Val Phe Ile 
                885                 890                 895


Met Leu Ser Ser Ala Ala Leu Ala Ala Glu Asp Pro Ile Arg Ser His 
            900                 905                 910


Ser Phe Arg Asn Thr Ile Leu Gly Tyr Phe Asp Tyr Ala Phe Thr Ala 
        915                 920                 925


Ile Phe Thr Val Glu Ile Leu Leu Lys Met Thr Thr Phe Gly Ala Phe 
    930                 935                 940


Leu His Lys Gly Ala Phe Cys Arg Asn Tyr Phe Asn Leu Leu Asp Met 
945                 950                 955                 960


Leu Val Val Gly Val Ser Leu Val Ser Phe Gly Ile Gln Ser Ser Ala 
                965                 970                 975


Ile Ser Val Val Lys Ile Leu Arg Val Leu Arg Val Leu Arg Pro Leu 
            980                 985                 990


Arg Ala Ile Asn Arg Ala Lys Gly Leu Lys His Val Val Gln Cys Val 
        995                 1000                1005


Phe Val Ala Ile Arg Thr Ile Gly Asn Ile Met Ile Val Thr Thr Leu 
    1010                1015                1020


Leu Gln Phe Met Phe Ala Cys Ile Gly Val Gln Leu Phe Lys Gly Lys 
1025                1030                1035                1040


Phe Tyr Arg Cys Thr Asp Glu Ala Lys Ser Asn Pro Glu Glu Cys Arg 
                1045                1050                1055


Gly Leu Phe Ile Leu Tyr Lys Asp Gly Asp Val Asp Ser Pro Val Val 
            1060                1065                1070


Arg Glu Arg Ile Trp Gln Asn Ser Asp Phe Asn Phe Asp Asn Val Leu 
        1075                1080                1085


Ser Ala Met Met Ala Leu Phe Thr Val Ser Thr Phe Glu Gly Trp Pro 
    1090                1095                1100


Ala Leu Leu Tyr Lys Ala Ile Asp Ser Asn Gly Glu Asn Ile Gly Pro 
1105                1110                1115                1120


Ile Tyr Asn His Arg Val Glu Ile Ser Ile Phe Phe Ile Ile Tyr Ile 
                1125                1130                1135


Ile Ile Val Ala Phe Phe Met Met Asn Ile Phe Val Gly Phe Val Ile 
            1140                1145                1150


Val Thr Phe Gln Glu Gln Gly Glu Lys Glu Tyr Lys Asn Cys Glu Leu 
        1155                1160                1165


Asp Lys Asn Gln Arg Gln Cys Val Glu Tyr Ala Leu Lys Ala Arg Pro 
    1170                1175                1180


Leu Arg Arg Tyr Ile Pro Lys Asn Pro Tyr Gln Tyr Lys Phe Trp Tyr 
1185                1190                1195                1200


Val Val Asn Ser Ser Pro Phe Glu Tyr Met Met Phe Val Leu Ile Met 
                1205                1210                1215


Leu Asn Thr Leu Cys Leu Ala Met Gln His Tyr Glu Gln Ser Lys Met 
            1220                1225                1230


Phe Asn Asp Ala Met Asp Ile Leu Asn Met Val Phe Thr Gly Val Phe 
        1235                1240                1245


Thr Val Glu Met Val Leu Lys Val Ile Ala Phe Lys Pro Lys Gly Tyr 
    1250                1255                1260


Phe Ser Asp Ala Trp Asn Thr Phe Asp Ser Leu Ile Val Ile Gly Ser 
1265                1270                1275                1280


Ile Ile Asp Val Ala Leu Ser Glu Ala Asp Pro Thr Glu Ser Glu Asn 
                1285                1290                1295


Val Pro Val Pro Thr Ala Thr Pro Gly Asn Ser Glu Glu Ser Asn Arg 
            1300                1305                1310


Ile Ser Ile Thr Phe Phe Arg Leu Phe Arg Val Met Arg Leu Val Lys 
        1315                1320                1325


Leu Leu Ser Arg Gly Glu Gly Ile Arg Thr Leu Leu Trp Thr Phe Ile 
    1330                1335                1340


Lys Ser Phe Gln Ala Leu Pro Tyr Val Ala Leu Leu Ile Ala Met Leu 
1345                1350                1355                1360


Phe Phe Ile Tyr Ala Val Ile Gly Met Gln Met Phe Gly Lys Val Ala 
                1365                1370                1375


Met Arg Asp Asn Asn Gln Ile Asn Arg Asn Asn Asn Phe Gln Thr Phe 
            1380                1385                1390


Pro Gln Ala Val Leu Leu Leu Phe Arg Cys Ala Thr Gly Glu Ala Trp 
        1395                1400                1405


Gln Glu Ile Met Leu Ala Cys Leu Pro Gly Lys Leu Cys Asp Pro Glu 
    1410                1415                1420


Ser Asp Tyr Asn Pro Gly Glu Glu Tyr Thr Cys Gly Ser Asn Phe Ala 
1425                1430                1435                1440


Ile Val Tyr Phe Ile Ser Phe Tyr Met Leu Cys Ala Phe Leu Ile Ile 
                1445                1450                1455


Asn Leu Phe Val Ala Val Ile Met Asp Asn Phe Asp Tyr Leu Thr Arg 
            1460                1465                1470


Asp Trp Ser Ile Leu Gly Pro His His Leu Asp Glu Phe Lys Arg Ile 
        1475                1480                1485


Trp Ser Glu Tyr Asp Pro Glu Ala Lys Gly Arg Ile Lys His Leu Asp 
    1490                1495                1500


Val Val Thr Leu Leu Arg Arg Ile Gln Pro Pro Leu Gly Phe Gly Lys 
1505                1510                1515                1520


Leu Cys Pro His Arg Val Ala Cys Lys Arg Leu Val Ala Met Asn Met 
                1525                1530                1535


Pro Leu Asn Ser Asp Gly Thr Val Met Phe Asn Ala Thr Leu Phe Ala 
            1540                1545                1550


Leu Val Arg Thr Ala Leu Lys Ile Lys Thr Glu Gly Asn Leu Glu Gln 
        1555                1560                1565


Ala Asn Glu Glu Leu Arg Ala Val Ile Lys Lys Ile Trp Lys Lys Thr 
    1570                1575                1580


Ser Met Lys Leu Leu Asp Gln Val Val Pro Pro Ala Gly Asp Asp Glu 
1585                1590                1595                1600


Val Thr Val Gly Lys Phe Tyr Ala Thr Phe Leu Ile Gln Asp Tyr Phe 
                1605                1610                1615


Arg Lys Phe Lys Lys Arg Lys Glu Gln Gly Leu Val Gly Lys Tyr Pro 
            1620                1625                1630


Ala Lys Asn Thr Thr Ile Ala Leu Gln Ala Gly Leu Arg Thr Leu His 
        1635                1640                1645


Asp Ile Gly Pro Glu Ile Arg Arg Ala Ile Ser Cys Asp Leu Gln Asp 
    1650                1655                1660


Asp Glu Pro Glu Glu Thr Lys Arg Glu Glu Glu Asp Asp Val Phe Lys 
1665                1670                1675                1680


Arg Asn Gly Ala Leu Leu Gly Asn His Val Asn His Val Asn Ser Asp 
                1685                1690                1695


Arg Arg Asp Ser Leu Gln Gln Thr Asn Thr Thr His Arg Pro Leu His 
            1700                1705                1710


Val Gln Arg Pro Ser Ile Pro Pro Ala Ser Asp Thr Glu Lys Pro Leu 
        1715                1720                1725


Phe Pro Pro Ala Gly Asn Ser Val Cys His Asn His His Asn His Asn 
    1730                1735                1740


Ser Ile Gly Lys Gln Val Pro Thr Ser Thr Asn Ala Asn Leu Asn Asn 
1745                1750                1755                1760


Ala Asn Met Ser Lys Ala Ala His Gly Lys Arg Pro Ser Ile Gly Asn 
                1765                1770                1775


Leu Glu His Val Ser Glu Asn Gly His His Ser Ser His Lys His Asp 
            1780                1785                1790


Arg Glu Pro Gln Arg Arg Ser Ser Val Lys Arg Thr Arg Tyr Tyr Glu 
        1795                1800                1805


Thr Tyr Ile Arg Ser Asp Ser Gly Asp Glu Gln Leu Pro Thr Ile Cys 
    1810                1815                1820


Arg Glu Asp Pro Glu Ile His Gly Tyr Phe Arg Asp Pro His Cys Leu 
1825                1830                1835                1840


Gly Glu Gln Glu Tyr Phe Ser Ser Glu Glu Cys Tyr Glu Asp Asp Ser 
                1845                1850                1855


Ser Pro Thr Trp Ser Arg Gln Asn Tyr Gly Tyr Tyr Ser Arg Tyr Pro 
            1860                1865                1870


Gly Arg Asn Ile Asp Ser Glu Arg Pro Arg Gly Tyr His His Pro Gln 
        1875                1880                1885


Gly Phe Leu Glu Asp Asp Asp Ser Pro Val Cys Tyr Asp Ser Arg Arg 
    1890                1895                1900


Ser Pro Arg Arg Arg Leu Leu Pro Pro Thr Pro Ala Ser His Arg Arg 
1905                1910                1915                1920


Ser Ser Phe Asn Phe Glu Cys Leu Arg Arg Gln Ser Ser Gln Glu Glu 
                1925                1930                1935


Val Pro Ser Ser Pro Ile Phe Pro His Arg Thr Ala Leu Pro Leu His 
            1940                1945                1950


Leu Met Gln Gln Gln Ile Met Ala Val Ala Gly Leu Asp Ser Ser Lys 
        1955                1960                1965


Ala Gln Lys Tyr Ser Pro Ser His Ser Thr Arg Ser Trp Ala Thr Pro 
    1970                1975                1980


Pro Ala Thr Pro Pro Tyr Arg Asp Trp Thr Pro Cys Tyr Thr Pro Leu 
1985                1990                1995                2000


Ile Gln Val Glu Gln Ser Glu Ala Leu Asp Gln Val Asn Gly Ser Leu 
                2005                2010                2015


Pro Ser Leu His Arg Ser Ser Trp Tyr Thr Asp Glu Pro Asp Ile Ser 
            2020                2025                2030


Tyr Arg Thr Phe Thr Pro Ala Ser Leu Thr Val Pro Ser Ser Phe Arg 
        2035                2040                2045


Asn Lys Asn Ser Asp Lys Gln Arg Ser Ala Asp Ser Leu Val Glu Ala 
    2050                2055                2060


Val Leu Ile Ser Glu Gly Leu Gly Arg Tyr Ala Arg Asp Pro Lys Phe 
2065                2070                2075                2080


Val Ser Ala Thr Lys His Glu Ile Ala Asp Ala Cys Asp Leu Thr Ile 
                2085                2090                2095


Asp Glu Met Glu Ser Ala Ala Ser Thr Leu Leu Asn Gly Asn Val Arg 
            2100                2105                2110


Pro Arg Ala Asn Gly Asp Val Gly Pro Leu Ser His Arg Gln Asp Tyr 
        2115                2120                2125


Glu Leu Gln Asp Phe Gly Pro Gly Tyr Ser Asp Glu Glu Pro Asp Pro 
    2130                2135                2140


Gly Arg Asp Glu Glu Asp Leu Ala Asp Glu Met Ile Cys Ile Thr Thr 
2145                2150                2155                2160


Leu 



<210>  2254
<211>  761
<212>  DNA
<213>  Homo sapiens

<400>  2254
cggctcctac ctcttggtga tccccttccc cattccgccc ccgcctcaac gcccagcaca     60

gtgccctgca cacagtagtc gctcaataaa tgttcgtgga tgatgatgat gatgatgatg    120

aaaaaaatgc agcatcaacg gcagcagcaa gcggaccacg cgaacgaggc aaactatgca    180

agaggcacca gacttcctct ttctggtgaa ggaccaactt ctcagccgaa tagctccaag    240

caaactgtcc tgtcttggca agctgcaatc gatgctgcta gacaggccaa ggctgcccaa    300

actatgagca cctctgcacc cccacctgta ggatctctct cccaaagaaa acgtcagcaa    360

tacgccaaga gcaaaaaaca gggtaactcg tccaacagcc gacctgcccg cgcccttttc    420

tgtttatcac tcaataaccc catccgaaga gcctgcatta gtatagtgga atggaaacca    480

tttgacatat ttatattatt ggctattttt gccaattgtg tggccttagc tatttacatc    540

ccattccctg aagatgattc taattcaaca aatcataact tggaaaaagt agaatatgcc    600

ttcctgatta tttttacagt cgagacattt ttgaagatta tagcgtatgg attattgcta    660

catcctaatg cttatgttag gaatggatgg aatttactgg attttgttat agtaatagta    720

gggtaagtct cttttacttt ggggaaatgt tgatttggaa a                        761


<210>  2255
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  2255

Met Met Met Met Met Met Met Lys Lys Met Gln His Gln Arg Gln Gln 
1               5                   10                  15


Gln Ala Asp His Ala Asn Glu Ala Asn Tyr Ala Arg Gly Thr Arg Leu 
            20                  25                  30


Pro Leu Ser Gly Glu Gly Pro Thr Ser Gln Pro Asn Ser Ser Lys Gln 
        35                  40                  45


Thr Val Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys 
    50                  55                  60


Ala Ala Gln Thr Met Ser Thr Ser Ala Pro Pro Pro Val Gly Ser Leu 
65                  70                  75                  80


Ser Gln Arg Lys Arg Gln Gln Tyr Ala Lys Ser Lys Lys Gln Gly Asn 
                85                  90                  95


Ser Ser Asn Ser Arg Pro Ala Arg Ala Leu Phe Cys Leu Ser Leu Asn 
            100                 105                 110


Asn Pro Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe 
        115                 120                 125


Asp Ile Phe Ile Leu Leu Ala Ile Phe Ala Asn Cys Val Ala Leu Ala 
    130                 135                 140


Ile Tyr Ile Pro Phe Pro Glu Asp Asp Ser Asn Ser Thr Asn His Asn 
145                 150                 155                 160


Leu Glu Lys Val Glu Tyr Ala Phe Leu Ile Ile Phe Thr Val Glu Thr 
                165                 170                 175


Phe Leu Lys Ile Ile Ala Tyr Gly Leu Leu Leu His Pro Asn Ala Tyr 
            180                 185                 190


Val Arg Asn Gly Trp Asn Leu Leu Asp Phe Val Ile Val Ile Val Gly 
        195                 200                 205


<210>  2256
<211>  5772
<212>  DNA
<213>  Homo sapiens

<400>  2256
acatgttact tcctgtatgg aggcatggcc agtttccagc cccgcgctct tcgttccttc     60

ccagcctgcg ccggagccac aactttcagg agcatggact gaaggcgccc tcgccccagc    120

gcccctctga gatcctttgt gttttcctcc gtttcctccg gccgtttcta ttttgggggg    180

ctctccgctc cccctgcctc tcccctcccc ttcccctctc gcaaacatgc ctccttcctt    240

cccggggccc tggaaggagc tgcctgcctg aagcccggag acgccgcgcc gcgctcagcc    300

ccgccgccgc ccgccggctc tcgggctgtg ctgcgctgcc gactcaagtt ggggatcctc    360

ggctgctcgc cgccgccgcc cgcggtccct gcctgcccca ggcccggggc atcgccgccg    420

gccgccgact ccgcgccctg cccgatcggc tctctccttt ttaaacggaa agcagccttt    480

ctccgccgag aggatcgtcc ccagcgtggc tctgcgttcc cggtcacttt ttgagatttt    540

ccggggggcg ctcggcggct tcccggattc caaggggact cgggccgccg agcgcggggg    600

gcccgtggag cgggcgagcc ggggaagcgc cccggcttag cggaggctcg cacggaggca    660

agaacttatt caacaagttt acctccctgc tttcctcttt tcgatgtgcg ttttcggaca    720

tgcggaggtt actggaaccg tgttggtgga ttttgttcct gaaaatcacc agttccgtgc    780

tccattatgt cgtgtgcttc cccgcgttga cagaaggcta cgttggggcc ctgcacgaga    840

atagacacgg cagcgcagtg cagatccgca ggcgcaaggc ttcaggcgac ccgtactggg    900

cctactctgg tgcctatggt cctgagcact gggtcacgtc tagtgtcagc tgtgggggcc    960

gtcaccagtc tcctattgac attttagacc agtatgcgcg tgttggggaa gaataccagg   1020

aactgcaact cgatggcttc gacaatgagt cttctaacaa aacctggatg aaaaacacag   1080

ggaaaacagt cgccatcctt ctgaaagacg actattttgt cagtggagct ggtctacctg   1140

gcagattcaa agctgagaag gtggaatttc actggggcca cagcaatggc tcagcgggct   1200

ctgaacacag catcaatggc aggaggtttc ctgttgagat gcagattttc ttttacaatc   1260

cagatgactt tgacagcttt caaaccgcaa tttctgagaa cagaataatc ggagccatgg   1320

ccatattttt tcaagtcagt ccgagggaca attctgcact ggatcctatt atccacgggt   1380

tgaagggtgt cgtacatcat gagaaggaga cctttctgga tcctttcgtc ctccgggacc   1440

tcctgcctgc atccctgggc agctattatc ggtacacagg ttccttgacc acaccaccgt   1500

gtagcgaaat agtggagtgg atagtcttcc ggagacccgt ccccatctct taccatcagc   1560

ttgaggcttt ttattccatc ttcaccacgg agcagcaaga ccatgtcaag tcggtggagt   1620

atctgagaaa taactttcga ccacagcagc gtctgcatga cagggtggtg tccaagtccg   1680

ccgtccgtga ctcctggaac cacgacatga cagacttctt agaaaaccca ctggggacag   1740

aagcctctaa agtttgcagc tctccaccca tccacatgaa ggtgcagcct ctgaaccaga   1800

cggcactgca ggtgtcctgg agccagccgg agactatcta ccacccaccc atcatgaact   1860

acatgatctc ctacagctgg accaagaatg aggacgagaa ggagaagacg tttacaaagg   1920

acagcgacaa agacttgaaa gccaccatta gccatgtctc acccgatagc ctttacctgt   1980

tccgagtcca ggccgtgtgt cggaacgaca tgcgcagcga ctttagccag acgatgctgt   2040

ttcaagctaa taccactcga atattccaag ggaccagaat agtgaaaaca ggagtgccca   2100

cagcgtctcc tgcctcttca gccgacatgg cccccatcag ctcggggtct tctacctgga   2160

cgtcctctgg catcccattc tcatttgttt ccatggcaac tgggatgggc ccctcctcca   2220

gtggcagcca ggccacagtg gcctcggtgg tcaccagcac gctgctcgcc ggcctggggt   2280

tcggcggtgg tggcatctcc tctttcccca gcactgtgtg gcccacgcgc ctcccgacgg   2340

ccgcctcagc cagcaagcag gcggctaggc cagtcctagc caccacagag gccttggctt   2400

ctccagggcc cgatggtgat tcgtcaccaa ccaaggacgg cgagggcacc gaggaaggag   2460

agaaggatga gaaaagcgag agtgaggatg gggagcggga gcacgaggag gatggagaga   2520

aggactccga aaagaaggag aagagtgggg tgacccacgc tgccgaggag cggaatcaga   2580

cggagcccag ccccacaccc tcgtctccta acaggactgc cgagggaggg catcagacta   2640

tacctgggca tgagcaggat cacactgccg tccccacaga ccagacgggc ggaaggaggg   2700

atgccggccc aggcctggac cccgacatgg tcacctccac ccaagtgccc cccaccgcca   2760

cagaggagca gtatgcaggg agtgatccca agaggcccga aatgccatct aaaaagccta   2820

tgtcccgcgg ggaccgattt tctgaagaca gcagatttat cactgttaat ccagcggaaa   2880

aaaacacctc tggaatgata agccgccctg ctccagggag gatggagtgg atcatccctc   2940

tgattgtggt atcagccttg accttcgtgt gcctcatcct tctcattgct gtgctcgttt   3000

actggagagg gtgtaacaaa ataaagtcca agggctttcc cagacgtttc cgtgaagtgc   3060

cttcttctgg ggagagagga gagaagggga gcagaaaatg ttttcagact gctcatttct   3120

atgtggaaga cagcagttca cctcgagtgg tccctaatga aagtatccct attattccta   3180

ttccggatga catggaagcc attcctgtca aacagtttgt caaacacatc ggtgagctct   3240

attctaataa ccagcatggg ttctctgagg attttgagga agtccagcgc tgtactgctg   3300

atatgaacat cactgcagag cattccaatc atccagaaaa caagcacaaa aacagataca   3360

tcaacatttt agcatatgat cacagtaggg tgaagttaag acctttacca ggaaaagact   3420

ctaagcacag cgactacatt aatgcaaact atgttgatgg ttacaacaaa gcaaaagcct   3480

acattgccac ccaaggacct ttgaagtcta catttgaaga tttctggagg atgatttggg   3540

aacaaaacac tggaatcatt gtgatgatta cgaaccttgt ggaaaaagga agacgaaaat   3600

gtgatcagta ttggccaaca gagaacagtg aggaatatgg aaacattatt gtcacgctga   3660

agagcacaaa aatacatgcc tgctacactg ttcgtcgttt ttcaatcaga aatacaaaag   3720

tgaaaaaggg tcagaaggga aatcccaagg gtcgtcagaa tgaaagggta gtgatccagt   3780

atcactatac acagtggcct gacatgggag ttcccgagta tgcccttcca gtactgactt   3840

tcgtgaggag atcctcagca gctcggatgc cagaaacggg ccctgtgttg gtgcactgca   3900

gtgctggtgt gggcagaaca ggcacctata ttgtaataga cagcatgctg caacagataa   3960

aagacaaaag cacagttaac gtcctgggat tcctgaagca tatcaggaca cagcgtaact   4020

acctcgtcca gactgaggag cagtacattt tcatccatga tgccttgttg gaagccattc   4080

ttggaaagga gactgaagta tcttcaaatc agctgcacag ctatgttaac agcatcctta   4140

taccaggagt aggaggaaag acacgactgg aaaagcaatt caagctggtc acacagtgta   4200

atgcaaaata tgtggaatgt ttcagtgctc agaaagagtg taacaaagaa aagaacagaa   4260

actcttcagt tgtgccatct gagcgtgctc gagtgggtct tgcaccattg cctggaatga   4320

aaggaacaga ttacattaat gcttcttata tcatgggcta ttataggagc aatgaattta   4380

ttataactca gcatcctctg ccacatacta cgaaagattt ctggcgaatg atttgggatc   4440

ataacgcaca gatcattgtc atgctgccag acaaccagag cttggcagaa gatgagtttg   4500

tgtactggcc aagtcgagaa gaatccatga actgtgaggc ctttaccgtc acccttatca   4560

gcaaagacag actgtgcctc tctaatgaag aacaaattat catccatgac tttatccttg   4620

aagctacaca ggatgactat gtcttagaag ttcggcactt tcagtgtccc aaatggccta   4680

acccagatgc ccccataagt agtacctttg aacttatcaa cgtcatcaag gaagaggcct   4740

taacaaggga tggtcccacc attgttcatg atgagtatgg agcagtttca gcaggaatgt   4800

tatgtgccct taccaccctg tcccagcaac tggagaatga aaatgctgtg gatgttttcc   4860

aggttgcaaa aatgatcaat cttatgaggc ctggagtatt cacagacatt gaacaatacc   4920

agttcatcta taaagcaatg cttagcttgg tcagcactaa agaaaatgga aatggtccca   4980

tgacagtaga caaaaatggt gctgttctta ttgcagatga atcagaccct gctgagagca   5040

tggagtccct agtgtgactg gaatcctgaa agggcactta atttgtaaac ttctgaagac   5100

tgagaacttt tttgaggcct tttttgccag actctaggtt atacaataac ccagttactt   5160

ttttacactg ataaaagttt tgatatttat tttttgccat tttatgtctt aatggtatcc   5220

tactgagcat ttgcacctct gttcatttca cacagtgaaa cgcaatttta cctagtttgc   5280

actatatgat cagtgttact gcctataatc ttatacaaca gcaaaccctg atgtgacatt   5340

ccatgacgac atacatgcta ctttttttta gttcaataca gtgaaggtct ttgttatgac   5400

agtgaatatt gcttttatta ttattattgc tgaagtggtt gcattctact agcaggcaat   5460

gctgtacttt tcttcagtcc tcctctcctt tttattttag gcactgttca atactgtatg   5520

ccttctgtat tttaatggag tggatagcat tgttttcttt tacagactag caggctactg   5580

ggacctaaaa aggtctgtta atgtcatggc cttgaaacag ttccatttat gctggttaag   5640

agatccctta agaagttaga aggcttaaga actgcttcat gtgaacatcc cttattagtt   5700

acaaagttat attcacagtt ttttaaaaat gtgtcaaaat aaaggataac tctgtattac   5760

agctttcaca gt                                                       5772


<210>  2257
<211>  1445
<212>  PRT
<213>  Homo sapiens

<400>  2257

Met Arg Arg Leu Leu Glu Pro Cys Trp Trp Ile Leu Phe Leu Lys Ile 
1               5                   10                  15


Thr Ser Ser Val Leu His Tyr Val Val Cys Phe Pro Ala Leu Thr Glu 
            20                  25                  30


Gly Tyr Val Gly Ala Leu His Glu Asn Arg His Gly Ser Ala Val Gln 
        35                  40                  45


Ile Arg Arg Arg Lys Ala Ser Gly Asp Pro Tyr Trp Ala Tyr Ser Gly 
    50                  55                  60


Ala Tyr Gly Pro Glu His Trp Val Thr Ser Ser Val Ser Cys Gly Gly 
65                  70                  75                  80


Arg His Gln Ser Pro Ile Asp Ile Leu Asp Gln Tyr Ala Arg Val Gly 
                85                  90                  95


Glu Glu Tyr Gln Glu Leu Gln Leu Asp Gly Phe Asp Asn Glu Ser Ser 
            100                 105                 110


Asn Lys Thr Trp Met Lys Asn Thr Gly Lys Thr Val Ala Ile Leu Leu 
        115                 120                 125


Lys Asp Asp Tyr Phe Val Ser Gly Ala Gly Leu Pro Gly Arg Phe Lys 
    130                 135                 140


Ala Glu Lys Val Glu Phe His Trp Gly His Ser Asn Gly Ser Ala Gly 
145                 150                 155                 160


Ser Glu His Ser Ile Asn Gly Arg Arg Phe Pro Val Glu Met Gln Ile 
                165                 170                 175


Phe Phe Tyr Asn Pro Asp Asp Phe Asp Ser Phe Gln Thr Ala Ile Ser 
            180                 185                 190


Glu Asn Arg Ile Ile Gly Ala Met Ala Ile Phe Phe Gln Val Ser Pro 
        195                 200                 205


Arg Asp Asn Ser Ala Leu Asp Pro Ile Ile His Gly Leu Lys Gly Val 
    210                 215                 220


Val His His Glu Lys Glu Thr Phe Leu Asp Pro Phe Val Leu Arg Asp 
225                 230                 235                 240


Leu Leu Pro Ala Ser Leu Gly Ser Tyr Tyr Arg Tyr Thr Gly Ser Leu 
                245                 250                 255


Thr Thr Pro Pro Cys Ser Glu Ile Val Glu Trp Ile Val Phe Arg Arg 
            260                 265                 270


Pro Val Pro Ile Ser Tyr His Gln Leu Glu Ala Phe Tyr Ser Ile Phe 
        275                 280                 285


Thr Thr Glu Gln Gln Asp His Val Lys Ser Val Glu Tyr Leu Arg Asn 
    290                 295                 300


Asn Phe Arg Pro Gln Gln Arg Leu His Asp Arg Val Val Ser Lys Ser 
305                 310                 315                 320


Ala Val Arg Asp Ser Trp Asn His Asp Met Thr Asp Phe Leu Glu Asn 
                325                 330                 335


Pro Leu Gly Thr Glu Ala Ser Lys Val Cys Ser Ser Pro Pro Ile His 
            340                 345                 350


Met Lys Val Gln Pro Leu Asn Gln Thr Ala Leu Gln Val Ser Trp Ser 
        355                 360                 365


Gln Pro Glu Thr Ile Tyr His Pro Pro Ile Met Asn Tyr Met Ile Ser 
    370                 375                 380


Tyr Ser Trp Thr Lys Asn Glu Asp Glu Lys Glu Lys Thr Phe Thr Lys 
385                 390                 395                 400


Asp Ser Asp Lys Asp Leu Lys Ala Thr Ile Ser His Val Ser Pro Asp 
                405                 410                 415


Ser Leu Tyr Leu Phe Arg Val Gln Ala Val Cys Arg Asn Asp Met Arg 
            420                 425                 430


Ser Asp Phe Ser Gln Thr Met Leu Phe Gln Ala Asn Thr Thr Arg Ile 
        435                 440                 445


Phe Gln Gly Thr Arg Ile Val Lys Thr Gly Val Pro Thr Ala Ser Pro 
    450                 455                 460


Ala Ser Ser Ala Asp Met Ala Pro Ile Ser Ser Gly Ser Ser Thr Trp 
465                 470                 475                 480


Thr Ser Ser Gly Ile Pro Phe Ser Phe Val Ser Met Ala Thr Gly Met 
                485                 490                 495


Gly Pro Ser Ser Ser Gly Ser Gln Ala Thr Val Ala Ser Val Val Thr 
            500                 505                 510


Ser Thr Leu Leu Ala Gly Leu Gly Phe Gly Gly Gly Gly Ile Ser Ser 
        515                 520                 525


Phe Pro Ser Thr Val Trp Pro Thr Arg Leu Pro Thr Ala Ala Ser Ala 
    530                 535                 540


Ser Lys Gln Ala Ala Arg Pro Val Leu Ala Thr Thr Glu Ala Leu Ala 
545                 550                 555                 560


Ser Pro Gly Pro Asp Gly Asp Ser Ser Pro Thr Lys Asp Gly Glu Gly 
                565                 570                 575


Thr Glu Glu Gly Glu Lys Asp Glu Lys Ser Glu Ser Glu Asp Gly Glu 
            580                 585                 590


Arg Glu His Glu Glu Asp Gly Glu Lys Asp Ser Glu Lys Lys Glu Lys 
        595                 600                 605


Ser Gly Val Thr His Ala Ala Glu Glu Arg Asn Gln Thr Glu Pro Ser 
    610                 615                 620


Pro Thr Pro Ser Ser Pro Asn Arg Thr Ala Glu Gly Gly His Gln Thr 
625                 630                 635                 640


Ile Pro Gly His Glu Gln Asp His Thr Ala Val Pro Thr Asp Gln Thr 
                645                 650                 655


Gly Gly Arg Arg Asp Ala Gly Pro Gly Leu Asp Pro Asp Met Val Thr 
            660                 665                 670


Ser Thr Gln Val Pro Pro Thr Ala Thr Glu Glu Gln Tyr Ala Gly Ser 
        675                 680                 685


Asp Pro Lys Arg Pro Glu Met Pro Ser Lys Lys Pro Met Ser Arg Gly 
    690                 695                 700


Asp Arg Phe Ser Glu Asp Ser Arg Phe Ile Thr Val Asn Pro Ala Glu 
705                 710                 715                 720


Lys Asn Thr Ser Gly Met Ile Ser Arg Pro Ala Pro Gly Arg Met Glu 
                725                 730                 735


Trp Ile Ile Pro Leu Ile Val Val Ser Ala Leu Thr Phe Val Cys Leu 
            740                 745                 750


Ile Leu Leu Ile Ala Val Leu Val Tyr Trp Arg Gly Cys Asn Lys Ile 
        755                 760                 765


Lys Ser Lys Gly Phe Pro Arg Arg Phe Arg Glu Val Pro Ser Ser Gly 
    770                 775                 780


Glu Arg Gly Glu Lys Gly Ser Arg Lys Cys Phe Gln Thr Ala His Phe 
785                 790                 795                 800


Tyr Val Glu Asp Ser Ser Ser Pro Arg Val Val Pro Asn Glu Ser Ile 
                805                 810                 815


Pro Ile Ile Pro Ile Pro Asp Asp Met Glu Ala Ile Pro Val Lys Gln 
            820                 825                 830


Phe Val Lys His Ile Gly Glu Leu Tyr Ser Asn Asn Gln His Gly Phe 
        835                 840                 845


Ser Glu Asp Phe Glu Glu Val Gln Arg Cys Thr Ala Asp Met Asn Ile 
    850                 855                 860


Thr Ala Glu His Ser Asn His Pro Glu Asn Lys His Lys Asn Arg Tyr 
865                 870                 875                 880


Ile Asn Ile Leu Ala Tyr Asp His Ser Arg Val Lys Leu Arg Pro Leu 
                885                 890                 895


Pro Gly Lys Asp Ser Lys His Ser Asp Tyr Ile Asn Ala Asn Tyr Val 
            900                 905                 910


Asp Gly Tyr Asn Lys Ala Lys Ala Tyr Ile Ala Thr Gln Gly Pro Leu 
        915                 920                 925


Lys Ser Thr Phe Glu Asp Phe Trp Arg Met Ile Trp Glu Gln Asn Thr 
    930                 935                 940


Gly Ile Ile Val Met Ile Thr Asn Leu Val Glu Lys Gly Arg Arg Lys 
945                 950                 955                 960


Cys Asp Gln Tyr Trp Pro Thr Glu Asn Ser Glu Glu Tyr Gly Asn Ile 
                965                 970                 975


Ile Val Thr Leu Lys Ser Thr Lys Ile His Ala Cys Tyr Thr Val Arg 
            980                 985                 990


Arg Phe Ser Ile Arg Asn Thr Lys Val Lys Lys Gly Gln Lys Gly Asn 
        995                 1000                1005


Pro Lys Gly Arg Gln Asn Glu Arg Val Val Ile Gln Tyr His Tyr Thr 
    1010                1015                1020


Gln Trp Pro Asp Met Gly Val Pro Glu Tyr Ala Leu Pro Val Leu Thr 
1025                1030                1035                1040


Phe Val Arg Arg Ser Ser Ala Ala Arg Met Pro Glu Thr Gly Pro Val 
                1045                1050                1055


Leu Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Val 
            1060                1065                1070


Ile Asp Ser Met Leu Gln Gln Ile Lys Asp Lys Ser Thr Val Asn Val 
        1075                1080                1085


Leu Gly Phe Leu Lys His Ile Arg Thr Gln Arg Asn Tyr Leu Val Gln 
    1090                1095                1100


Thr Glu Glu Gln Tyr Ile Phe Ile His Asp Ala Leu Leu Glu Ala Ile 
1105                1110                1115                1120


Leu Gly Lys Glu Thr Glu Val Ser Ser Asn Gln Leu His Ser Tyr Val 
                1125                1130                1135


Asn Ser Ile Leu Ile Pro Gly Val Gly Gly Lys Thr Arg Leu Glu Lys 
            1140                1145                1150


Gln Phe Lys Leu Val Thr Gln Cys Asn Ala Lys Tyr Val Glu Cys Phe 
        1155                1160                1165


Ser Ala Gln Lys Glu Cys Asn Lys Glu Lys Asn Arg Asn Ser Ser Val 
    1170                1175                1180


Val Pro Ser Glu Arg Ala Arg Val Gly Leu Ala Pro Leu Pro Gly Met 
1185                1190                1195                1200


Lys Gly Thr Asp Tyr Ile Asn Ala Ser Tyr Ile Met Gly Tyr Tyr Arg 
                1205                1210                1215


Ser Asn Glu Phe Ile Ile Thr Gln His Pro Leu Pro His Thr Thr Lys 
            1220                1225                1230


Asp Phe Trp Arg Met Ile Trp Asp His Asn Ala Gln Ile Ile Val Met 
        1235                1240                1245


Leu Pro Asp Asn Gln Ser Leu Ala Glu Asp Glu Phe Val Tyr Trp Pro 
    1250                1255                1260


Ser Arg Glu Glu Ser Met Asn Cys Glu Ala Phe Thr Val Thr Leu Ile 
1265                1270                1275                1280


Ser Lys Asp Arg Leu Cys Leu Ser Asn Glu Glu Gln Ile Ile Ile His 
                1285                1290                1295


Asp Phe Ile Leu Glu Ala Thr Gln Asp Asp Tyr Val Leu Glu Val Arg 
            1300                1305                1310


His Phe Gln Cys Pro Lys Trp Pro Asn Pro Asp Ala Pro Ile Ser Ser 
        1315                1320                1325


Thr Phe Glu Leu Ile Asn Val Ile Lys Glu Glu Ala Leu Thr Arg Asp 
    1330                1335                1340


Gly Pro Thr Ile Val His Asp Glu Tyr Gly Ala Val Ser Ala Gly Met 
1345                1350                1355                1360


Leu Cys Ala Leu Thr Thr Leu Ser Gln Gln Leu Glu Asn Glu Asn Ala 
                1365                1370                1375


Val Asp Val Phe Gln Val Ala Lys Met Ile Asn Leu Met Arg Pro Gly 
            1380                1385                1390


Val Phe Thr Asp Ile Glu Gln Tyr Gln Phe Ile Tyr Lys Ala Met Leu 
        1395                1400                1405


Ser Leu Val Ser Thr Lys Glu Asn Gly Asn Gly Pro Met Thr Val Asp 
    1410                1415                1420


Lys Asn Gly Ala Val Leu Ile Ala Asp Glu Ser Asp Pro Ala Glu Ser 
1425                1430                1435                1440


Met Glu Ser Leu Val 
                1445


<210>  2258
<211>  9362
<212>  DNA
<213>  Homo sapiens

<400>  2258
acatgttact tcctgtatgg aggcatggcc agtttccagc cccgcgctct tcgttccttc     60

ccagcctgcg ccggagccac aactttcagg agcatggact gaaggcgccc tcgccccagc    120

gcccctctga gatcctttgt gttttcctcc gtttcctccg gccgtttcta ttttgggggg    180

ctctccgctc cccctgcctc tcccctcccc ttcccctctc gcaaacatgc ctccttcctt    240

cccggggccc tggaaggagc tgcctgcctg aagcccggag acgccgcgcc gcgctcagcc    300

ccgccgccgc ccgccggctc tcgggctgtg ctgcgctgcc gactcaagtt ggggatcctc    360

ggctgctcgc cgccgccgcc cgcggtccct gcctgcccca ggcccggggc atcgccgccg    420

gccgccgact ccgcgccctg cccgatcggc tctctccttt ttaaacggaa agcagccttt    480

ctccgccgag aggatcgtcc ccagcgtggc tctgcgttcc cggtcacttt ttgagatttt    540

ccggggggcg ctcggcggct tcccggattc caaggggact cgggccgccg agcgcggggg    600

gcccgtggag cgggcgagcc ggggaagcgc cccggcttag cggaggctcg cacggaggca    660

agaacttatt caacaagttt acctccctgc tttcctcttt tcgatgtgcg ttttcggaca    720

tgcggaggtt actggaaccg tgttggtgga ttttgttcct gaaaatcacc agttccgtgc    780

tccattatgt cgtgtgcttc cccgcgttga cagaaggcta cgttggggcc ctgcacgaga    840

atagacacgg cagcgcagtg cagatccgca ggcgcaaggc ttcaggcgac ccgtactggg    900

cctactctgg tgcctatggt cctgagcact gggtcacgtc tagtgtcagc tgtgggggcc    960

gtcaccagtc tcctattgac attttagacc agtatgcgcg tgttggggaa gaataccagg   1020

aactgcaact cgatggcttc gacaatgagt cttctaacaa aacctggatg aaaaacacag   1080

ggaaaacagt cgccatcctt ctgaaagacg actattttgt cagtggagct ggtctacctg   1140

gcagattcaa agctgagaag gtggaatttc actggggcca cagcaatggc tcagcgggct   1200

ctgaacacag catcaatggc aggaggtttc ctgttgagat gcagattttc ttttacaatc   1260

cagatgactt tgacagcttt caaaccgcaa tttctgagaa cagaataatc ggagccatgg   1320

ccatattttt tcaagtcagt ccgagggaca attctgcact ggatcctatt atccacgggt   1380

tgaagggtgt cgtacatcat gagaaggaga cctttctgga tcctttcgtc ctccgggacc   1440

tcctgcctgc atccctgggc agctattatc ggtacacagg ttccttgacc acaccaccgt   1500

gtagcgaaat agtggagtgg atagtcttcc ggagacccgt ccccatctct taccatcagc   1560

ttgaggcttt ttattccatc ttcaccacgg agcagcaaga ccatgtcaag tcggtggagt   1620

atctgagaaa taactttcga ccacagcagc gtctgcatga cagggtggtg tccaagtccg   1680

ccgtccgtga ctcctggaac cacgacatga cagacttctt agaaaaccca ctggggacag   1740

aagcctctaa agtttgcagc tctccaccca tccacatgaa ggtgcagcct ctgaaccaga   1800

cggcactgca ggtgtcctgg agccagccgg agactatcta ccacccaccc atcatgaact   1860

acatgatctc ctacagctgg accaagaatg aggacgagaa ggagaagacg tttacaaagg   1920

acagcgacaa agacttgaaa gccaccatta gccatgtctc acccgatagc ctttacctgt   1980

tccgagtcca ggccgtgtgt cggaacgaca tgcgcagcga ctttagccag acgatgctgt   2040

ttcaagctaa taccactcga atattccaag ggaccagaat agtgaaaaca ggagtgccca   2100

cagcgtctcc tgcctcttca gccgacatgg cccccatcag ctcggggtct tctacctgga   2160

cgtcctctgg catcccattc tcatttgttt ccatggcaac tgggatgggc ccctcctcca   2220

gtggcagcca ggccacagtg gcctcggtgg tcaccagcac gctgctcgcc ggcctggggt   2280

tcggcggtgg tggcatctcc tctttcccca gcactgtgtg gcccacgcgc ctcccgacgg   2340

ccgcctcagc cagcaagcag gcggctaggc cagtcctagc caccacagag gccttggctt   2400

ctccagggcc cgatggtgat tcgtcaccaa ccaaggacgg cgagggcacc gaggaaggag   2460

agaaggatga gaaaagcgag agtgaggatg gggagcggga gcacgaggag gatggagaga   2520

aggactccga aaagaaggag aagagtgggg tgacccacgc tgccgaggag cggaatcaga   2580

cggagcccag ccccacaccc tcgtctccta acaggactgc cgagggaggg catcagacta   2640

tacctgggca tgagcaggat cacactgccg tccccacaga ccagacgggc ggaaggaggg   2700

atgccggccc aggcctggac cccgacatgg tcacctccac ccaagtgccc cccaccgcca   2760

cagaggagca gtatgcaggg agtgatccca agaggcccga aatgccatct aaaaagccta   2820

tgtcccgcgg ggaccgattt tctgaagaca gcagatttat cactgttaat ccagcggaaa   2880

aaaacacctc tggaatgata agccgccctg ctccagggag gatggagtgg atcatccctc   2940

tgattgtggt atcagccttg accttcgtgt gcctcatcct tctcattgct gtgctcgttt   3000

actggagagg gtgtaacaaa ataaagtcca agggctttcc cagacgtttc cgtgaagtgc   3060

cttcttctgg ggagagagga gagaagggga gcagaaaatg ttttcagact gctcatttct   3120

atgtggaaga cagcagttca cctcgagtgg tccctaatga aagtatccct attattccta   3180

ttccggatga catggaagcc attcctgtca aacagtttgt caaacacatc ggtgagctct   3240

attctaataa ccagcatggg ttctctgagg attttgagga agtccagcgc tgtactgctg   3300

atatgaacat cactgcagag cattccaatc atccagaaaa caagcacaaa aacagataca   3360

tcaacatttt agcatatgat cacagtaggg tgaagttaag acctttacca ggaaaagact   3420

ctaagcacag cgactacatt aatgcaaact atgttgatgg ttacaacaaa gcaaaagcct   3480

acattgccac ccaaggacct ttgaagtcta catttgaaga tttctggagg atgatttggg   3540

aacaaaacac tggaatcatt gtgatgatta cgaaccttgt ggaaaaagga agacgaaaat   3600

gtgatcagta ttggccaaca gagaacagtg aggaatatgg aaacattatt gtcacgctga   3660

agagcacaaa aatacatgcc tgctacactg ttcgtcgttt ttcaatcaga aatacaaaag   3720

tgaaaaaggg tcagaaggga aatcccaagg gtcgtcagaa tgaaagggta gtgatccagt   3780

atcactatac acagtggcct gacatgggag ttcccgagta tgcccttcca gtactgactt   3840

tcgtgaggag atcctcagca gctcggatgc cagaaacggg ccctgtgttg gtgcactgca   3900

gtgctggtgt gggcagaaca ggcacctata ttgtaataga cagcatgctg caacagataa   3960

aagacaaaag cacagttaac gtcctgggat tcctgaagca tatcaggaca cagcgtaact   4020

acctcgtcca gactgaggag cagtacattt tcatccatga tgccttgttg gaagccattc   4080

ttggaaagga gactgaagta tcttcaaatc agctgcacag ctatgttaac agcatcctta   4140

taccaggagt aggaggaaag acacgactgg aaaagcaatt caagctggtc acacagtgta   4200

atgcaaaata tgtggaatgt ttcagtgctc agaaagagtg taacaaagaa aagaacagaa   4260

actcttcagt tgtgccatct gagcgtgctc gagtgggtct tgcaccattg cctggaatga   4320

aaggaacaga ttacattaat gcttcttata tcatgggcta ttataggagc aatgaattta   4380

ttataactca gcatcctctg ccacatacta cgaaagattt ctggcgaatg atttgggatc   4440

ataacgcaca gatcattgtc atgctgccag acaaccagag cttggcagaa gatgagtttg   4500

tgtactggcc aagtcgagaa gaatccatga actgtgaggc ctttaccgtc acccttatca   4560

gcaaagacag actgtgcctc tctaatgaag aacaaattat catccatgac tttatccttg   4620

aagctacaca ggatgactat gtcttagaag ttcggcactt tcagtgtccc aaatggccta   4680

acccagatgc ccccataagt agtacctttg aacttatcaa cgtcatcaag gaagaggcct   4740

taacaaggga tggtcccacc attgttcatg atgagtatgg agcagtttca gcaggaatgt   4800

tatgtgccct taccaccctg tcccagcaac tggagaatga aaatgctgtg gatgttttcc   4860

aggttgcaaa aatgatcaat cttatgaggc ctggagtatt cacagacatt gaacaatacc   4920

agttcatcta taaagcaatg cttagcttgg tcagcactaa agaaaatgga aatggtccca   4980

tgacagtaga caaaaatggt gctgttctta ttgcagatga atcagaccct gctgagagca   5040

tggagtccct agtgtgactg gaatcctgaa agggcactta atttgtaaac ttctgaagac   5100

tgagaacttt tttgaggcct tttttgccag actctaggtt atacaataac ccagttactt   5160

ttttacactg ataaaagttt tgatatttat tttttgccat tttatgtctt aatggtatcc   5220

tactgagcat ttgcacctct gttcatttca cacagtgaaa cgcaatttta cctagtttgc   5280

actatatgat cagtgttact gcctataatc ttatacaaca gcaaaccctg atgtgacatt   5340

ccatgacgac atacatgcta ctttttttta gttcaataca gtgaaggtct ttgttatgac   5400

agtgaatatt gcttttatta ttattattgc tgaagtggtt gcattctact agcaggcaat   5460

gctgtacttt tcttcagtcc tcctctcctt tttattttag gcactgttca atactgtatg   5520

ccttctgtat tttaatggag tggatagcat tgttttcttt tacagactag caggctactg   5580

ggacctaaaa aggtctgtta atgtcatggc cttgaaacag ttccatttat gctggttaag   5640

agatccctta agaagttaga aggcttaaga actgcttcat gtgaacatcc cttattagtt   5700

acaaagttat attcacagtt ttttaaaaat gtgtcaaaat aaaggataac tctgtattac   5760

agctttcaca gtagctatgt ggacaatgtg ttatttccat tttgactctc taaaatagct   5820

acatcctaaa atcagggcta tctttaacaa tagcaagata gcaatattat atacaactca   5880

gttatgagac cctttagtta ttctccatta atgcttctta gtttgtaata ccatacctca   5940

cagtaggtag aagaatgaaa acttctgcag gtgtgtaatt ttgaaactag tcctctaaaa   6000

attccctatt actcctatag caatctaata aaaactacct acatagttac tgttttcttt   6060

ccttctttgc caaatgtttt ataataaatc tcttaattac atacattttt ctacttaaga   6120

ttaaattgga aatactgtct tagcaaaagt cttgggacta tctaaactcc cacacataga   6180

taaatctgat ttggagagag aaatttaaaa tatttaatta aaggtgatac ccacattttc   6240

aagtttttaa aagagggaga tggctttgta tgcttttgtg tagtttagaa cagatacaca   6300

ttagtaaaag ataccaataa tcattagagc tcaaggaagt tattaggtgc agcctctgga   6360

gccatactca cgctgcagtg cataatggga aaattaggag cattaataag aaatttcagt   6420

agtgtttgta aggaaaataa gctacttact gagatctgtt tcttctattg catgtttgct   6480

tttgagggac agcttctgtc aaaagtgaaa tcatcaccag aactgggcct gttaggaaga   6540

atagggtttt atttactttt tatgtcaatt aacttcaaca aaaaggccac gctggctgct   6600

gtcatgccat ctgggtatgc attaaacatt aatgatgatc agcactgagg ttctatttat   6660

cttgatttgg ctttcataaa gtttgtcaga atggtgctgg aggaccagaa gtgctaagga   6720

gaaagaagct atgggccaag ttaaagaatt tgaatgcaaa ggccaggtca atggagtttt   6780

cataaactac ataatttacc agggtttatc tcatcttctc aatacataga tttaacaaca   6840

tggaatactc tgcttttcaa gagctgcgta agctagtcct gagataagat gttcaagaga   6900

gcatgctaag ttgcatgtgc tagatgagag acacctttac agcccctccg ctccaaccag   6960

aggtgacaca ggaagctctg taaagttcaa gtaaagcttg aacacaggaa cactacaact   7020

gccagatgct gaggagaatc aggaaagcaa tgagctagac tcttttttta gtcaattaag   7080

tgggttgttt tagatgtata gagtattgat atgagttaac actttttagt agatggcaaa   7140

gtgggcttga tgttcaaaag taatgttcga gttagggttc atggtccctt tctcagtaat   7200

tttttcttaa taaaagtaaa cactggttca aagacaaata gcaagtattc cctcctgtgc   7260

tatttataga gggctcaatt cgtagaaagg cataccctcc aatgcaattc tgtggctgtc   7320

ccttacagtg gtttcagaat cacgaaaaaa cagctagtaa ataggataga aacaataaaa   7380

gaaagagttt agaagttccc tgtgagcaat ctgtgtgtct tcagcgagct tgaaccaaag   7440

tcttcatatc ctgacccact gaattataag caattgctac ttgcccatct tgccaaagta   7500

gtccaaacac acttcaatga ggacagttat atttagcagg tcctcacccc tgcaagagac   7560

agcatatcct cactattatt attcatgtgt tattggcaaa aacatagctt gcatctttcc   7620

agaggcagag tttcaaagac agggttttct ttgagacata agcacattgc ttaagtacat   7680

aacaaggtta ttaacacttg cactcagggg aaaggaaata gctattgcaa attaatgtgt   7740

gcaacttaat aaaataagct gtttgtgtat atgaatttag ctctaggtaa gcaaaatgca   7800

cacatcatat aaaaataaat tgcaatgatc agaccaagtg gctgtgctgg acatcaaaga   7860

aaagacatgc tgttgccatc aggagaactc tttcttatat gcgatagcca agatatcttc   7920

tttaatatga aaaaagttaa tttctgaatt tcaaaaagag taagattagc taattggtct   7980

tcctaatttt tatgccttta gagtttttag tctattcaag tagaagagtc cagcgaggcc   8040

aaagaagggt tacggtgttc aagttctggt tgttggagtt tttagcccag agtgacatac   8100

tgaaatcagt aaataattat tttataatga cacagcacaa ctgccttgtt atgaattttt   8160

cttaaatgca tatatactgt atttaaaatt aaaatataga taccaattta ccaaagatac   8220

atattactaa ttctaagcaa aactaaaaaa aaaacccaac tcatcataat ttaagaatca   8280

aaatgtagtt tgtcttaaga atttagtggt tatactggaa atgcattttc aactcctatg   8340

ttctaaagtt tatgttcaaa tggtgccagt gaatttttat atgaagggaa aatgcctgct   8400

tttttttttt ttttaacaga tgtaatttca cttaaccctt tgcgctttcc cttagttgtc   8460

atttaacata caatactggc tttacttatc tctagaaaga agaaggcatg ctacaaatag   8520

gaaggaattg taataatgat atttggcctc tactttgtct tagctgttaa actgttttta   8580

gtatttttgt taaatatttg caaagggaag cattttctac agaggataat taatttcaag   8640

aaaaatatct tgagttttaa gaaataaaca tctccagaaa aggagaaagt cgattttata   8700

aaatgtcgca actctccaac atttggggta gtgactcctt ttttgttagg acatttgaaa   8760

ctagcaagca gccattgttt ctaaagaatt ctggcttcac attgactcat gtttctttca   8820

ctccattttg aaatagctaa aaatcattaa aactgtaaat attttgttgc ttgggtaagc   8880

atcttctggg aactttgtat ctatggtata taatcataga attttatatt ttcatataaa   8940

gctaattttt ttctagtttc aactccgtca tagttttttt tcctttttgt ggtggatatg   9000

tgaattcaac tttctgtgta ttgaagtagc aaaaaccatc tttacattcc aaaagaatcc   9060

aacatgtgtt atttctttga ggcagtgatt gtgaaagttg ggttttcttt ttaattccat   9120

tgaccatttg tgcaatagga attagacata attagtcact gaaaacattc gtcacattga   9180

cccatttgga aaaagtgtgc tttttttttt tttttaaatt tgttcagggg gaggggtttt   9240

gtaacctgaa atttttccct ttttcttctg tttaaactat atcaaatcat tctattatag   9300

tgttatttaa tatgtaaatt gtattgctat acataaaata aagtatggtt tttgatgtat   9360

tc                                                                  9362


<210>  2259
<211>  1445
<212>  PRT
<213>  Homo sapiens

<400>  2259

Met Arg Arg Leu Leu Glu Pro Cys Trp Trp Ile Leu Phe Leu Lys Ile 
1               5                   10                  15


Thr Ser Ser Val Leu His Tyr Val Val Cys Phe Pro Ala Leu Thr Glu 
            20                  25                  30


Gly Tyr Val Gly Ala Leu His Glu Asn Arg His Gly Ser Ala Val Gln 
        35                  40                  45


Ile Arg Arg Arg Lys Ala Ser Gly Asp Pro Tyr Trp Ala Tyr Ser Gly 
    50                  55                  60


Ala Tyr Gly Pro Glu His Trp Val Thr Ser Ser Val Ser Cys Gly Gly 
65                  70                  75                  80


Arg His Gln Ser Pro Ile Asp Ile Leu Asp Gln Tyr Ala Arg Val Gly 
                85                  90                  95


Glu Glu Tyr Gln Glu Leu Gln Leu Asp Gly Phe Asp Asn Glu Ser Ser 
            100                 105                 110


Asn Lys Thr Trp Met Lys Asn Thr Gly Lys Thr Val Ala Ile Leu Leu 
        115                 120                 125


Lys Asp Asp Tyr Phe Val Ser Gly Ala Gly Leu Pro Gly Arg Phe Lys 
    130                 135                 140


Ala Glu Lys Val Glu Phe His Trp Gly His Ser Asn Gly Ser Ala Gly 
145                 150                 155                 160


Ser Glu His Ser Ile Asn Gly Arg Arg Phe Pro Val Glu Met Gln Ile 
                165                 170                 175


Phe Phe Tyr Asn Pro Asp Asp Phe Asp Ser Phe Gln Thr Ala Ile Ser 
            180                 185                 190


Glu Asn Arg Ile Ile Gly Ala Met Ala Ile Phe Phe Gln Val Ser Pro 
        195                 200                 205


Arg Asp Asn Ser Ala Leu Asp Pro Ile Ile His Gly Leu Lys Gly Val 
    210                 215                 220


Val His His Glu Lys Glu Thr Phe Leu Asp Pro Phe Val Leu Arg Asp 
225                 230                 235                 240


Leu Leu Pro Ala Ser Leu Gly Ser Tyr Tyr Arg Tyr Thr Gly Ser Leu 
                245                 250                 255


Thr Thr Pro Pro Cys Ser Glu Ile Val Glu Trp Ile Val Phe Arg Arg 
            260                 265                 270


Pro Val Pro Ile Ser Tyr His Gln Leu Glu Ala Phe Tyr Ser Ile Phe 
        275                 280                 285


Thr Thr Glu Gln Gln Asp His Val Lys Ser Val Glu Tyr Leu Arg Asn 
    290                 295                 300


Asn Phe Arg Pro Gln Gln Arg Leu His Asp Arg Val Val Ser Lys Ser 
305                 310                 315                 320


Ala Val Arg Asp Ser Trp Asn His Asp Met Thr Asp Phe Leu Glu Asn 
                325                 330                 335


Pro Leu Gly Thr Glu Ala Ser Lys Val Cys Ser Ser Pro Pro Ile His 
            340                 345                 350


Met Lys Val Gln Pro Leu Asn Gln Thr Ala Leu Gln Val Ser Trp Ser 
        355                 360                 365


Gln Pro Glu Thr Ile Tyr His Pro Pro Ile Met Asn Tyr Met Ile Ser 
    370                 375                 380


Tyr Ser Trp Thr Lys Asn Glu Asp Glu Lys Glu Lys Thr Phe Thr Lys 
385                 390                 395                 400


Asp Ser Asp Lys Asp Leu Lys Ala Thr Ile Ser His Val Ser Pro Asp 
                405                 410                 415


Ser Leu Tyr Leu Phe Arg Val Gln Ala Val Cys Arg Asn Asp Met Arg 
            420                 425                 430


Ser Asp Phe Ser Gln Thr Met Leu Phe Gln Ala Asn Thr Thr Arg Ile 
        435                 440                 445


Phe Gln Gly Thr Arg Ile Val Lys Thr Gly Val Pro Thr Ala Ser Pro 
    450                 455                 460


Ala Ser Ser Ala Asp Met Ala Pro Ile Ser Ser Gly Ser Ser Thr Trp 
465                 470                 475                 480


Thr Ser Ser Gly Ile Pro Phe Ser Phe Val Ser Met Ala Thr Gly Met 
                485                 490                 495


Gly Pro Ser Ser Ser Gly Ser Gln Ala Thr Val Ala Ser Val Val Thr 
            500                 505                 510


Ser Thr Leu Leu Ala Gly Leu Gly Phe Gly Gly Gly Gly Ile Ser Ser 
        515                 520                 525


Phe Pro Ser Thr Val Trp Pro Thr Arg Leu Pro Thr Ala Ala Ser Ala 
    530                 535                 540


Ser Lys Gln Ala Ala Arg Pro Val Leu Ala Thr Thr Glu Ala Leu Ala 
545                 550                 555                 560


Ser Pro Gly Pro Asp Gly Asp Ser Ser Pro Thr Lys Asp Gly Glu Gly 
                565                 570                 575


Thr Glu Glu Gly Glu Lys Asp Glu Lys Ser Glu Ser Glu Asp Gly Glu 
            580                 585                 590


Arg Glu His Glu Glu Asp Gly Glu Lys Asp Ser Glu Lys Lys Glu Lys 
        595                 600                 605


Ser Gly Val Thr His Ala Ala Glu Glu Arg Asn Gln Thr Glu Pro Ser 
    610                 615                 620


Pro Thr Pro Ser Ser Pro Asn Arg Thr Ala Glu Gly Gly His Gln Thr 
625                 630                 635                 640


Ile Pro Gly His Glu Gln Asp His Thr Ala Val Pro Thr Asp Gln Thr 
                645                 650                 655


Gly Gly Arg Arg Asp Ala Gly Pro Gly Leu Asp Pro Asp Met Val Thr 
            660                 665                 670


Ser Thr Gln Val Pro Pro Thr Ala Thr Glu Glu Gln Tyr Ala Gly Ser 
        675                 680                 685


Asp Pro Lys Arg Pro Glu Met Pro Ser Lys Lys Pro Met Ser Arg Gly 
    690                 695                 700


Asp Arg Phe Ser Glu Asp Ser Arg Phe Ile Thr Val Asn Pro Ala Glu 
705                 710                 715                 720


Lys Asn Thr Ser Gly Met Ile Ser Arg Pro Ala Pro Gly Arg Met Glu 
                725                 730                 735


Trp Ile Ile Pro Leu Ile Val Val Ser Ala Leu Thr Phe Val Cys Leu 
            740                 745                 750


Ile Leu Leu Ile Ala Val Leu Val Tyr Trp Arg Gly Cys Asn Lys Ile 
        755                 760                 765


Lys Ser Lys Gly Phe Pro Arg Arg Phe Arg Glu Val Pro Ser Ser Gly 
    770                 775                 780


Glu Arg Gly Glu Lys Gly Ser Arg Lys Cys Phe Gln Thr Ala His Phe 
785                 790                 795                 800


Tyr Val Glu Asp Ser Ser Ser Pro Arg Val Val Pro Asn Glu Ser Ile 
                805                 810                 815


Pro Ile Ile Pro Ile Pro Asp Asp Met Glu Ala Ile Pro Val Lys Gln 
            820                 825                 830


Phe Val Lys His Ile Gly Glu Leu Tyr Ser Asn Asn Gln His Gly Phe 
        835                 840                 845


Ser Glu Asp Phe Glu Glu Val Gln Arg Cys Thr Ala Asp Met Asn Ile 
    850                 855                 860


Thr Ala Glu His Ser Asn His Pro Glu Asn Lys His Lys Asn Arg Tyr 
865                 870                 875                 880


Ile Asn Ile Leu Ala Tyr Asp His Ser Arg Val Lys Leu Arg Pro Leu 
                885                 890                 895


Pro Gly Lys Asp Ser Lys His Ser Asp Tyr Ile Asn Ala Asn Tyr Val 
            900                 905                 910


Asp Gly Tyr Asn Lys Ala Lys Ala Tyr Ile Ala Thr Gln Gly Pro Leu 
        915                 920                 925


Lys Ser Thr Phe Glu Asp Phe Trp Arg Met Ile Trp Glu Gln Asn Thr 
    930                 935                 940


Gly Ile Ile Val Met Ile Thr Asn Leu Val Glu Lys Gly Arg Arg Lys 
945                 950                 955                 960


Cys Asp Gln Tyr Trp Pro Thr Glu Asn Ser Glu Glu Tyr Gly Asn Ile 
                965                 970                 975


Ile Val Thr Leu Lys Ser Thr Lys Ile His Ala Cys Tyr Thr Val Arg 
            980                 985                 990


Arg Phe Ser Ile Arg Asn Thr Lys Val Lys Lys Gly Gln Lys Gly Asn 
        995                 1000                1005


Pro Lys Gly Arg Gln Asn Glu Arg Val Val Ile Gln Tyr His Tyr Thr 
    1010                1015                1020


Gln Trp Pro Asp Met Gly Val Pro Glu Tyr Ala Leu Pro Val Leu Thr 
1025                1030                1035                1040


Phe Val Arg Arg Ser Ser Ala Ala Arg Met Pro Glu Thr Gly Pro Val 
                1045                1050                1055


Leu Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Val 
            1060                1065                1070


Ile Asp Ser Met Leu Gln Gln Ile Lys Asp Lys Ser Thr Val Asn Val 
        1075                1080                1085


Leu Gly Phe Leu Lys His Ile Arg Thr Gln Arg Asn Tyr Leu Val Gln 
    1090                1095                1100


Thr Glu Glu Gln Tyr Ile Phe Ile His Asp Ala Leu Leu Glu Ala Ile 
1105                1110                1115                1120


Leu Gly Lys Glu Thr Glu Val Ser Ser Asn Gln Leu His Ser Tyr Val 
                1125                1130                1135


Asn Ser Ile Leu Ile Pro Gly Val Gly Gly Lys Thr Arg Leu Glu Lys 
            1140                1145                1150


Gln Phe Lys Leu Val Thr Gln Cys Asn Ala Lys Tyr Val Glu Cys Phe 
        1155                1160                1165


Ser Ala Gln Lys Glu Cys Asn Lys Glu Lys Asn Arg Asn Ser Ser Val 
    1170                1175                1180


Val Pro Ser Glu Arg Ala Arg Val Gly Leu Ala Pro Leu Pro Gly Met 
1185                1190                1195                1200


Lys Gly Thr Asp Tyr Ile Asn Ala Ser Tyr Ile Met Gly Tyr Tyr Arg 
                1205                1210                1215


Ser Asn Glu Phe Ile Ile Thr Gln His Pro Leu Pro His Thr Thr Lys 
            1220                1225                1230


Asp Phe Trp Arg Met Ile Trp Asp His Asn Ala Gln Ile Ile Val Met 
        1235                1240                1245


Leu Pro Asp Asn Gln Ser Leu Ala Glu Asp Glu Phe Val Tyr Trp Pro 
    1250                1255                1260


Ser Arg Glu Glu Ser Met Asn Cys Glu Ala Phe Thr Val Thr Leu Ile 
1265                1270                1275                1280


Ser Lys Asp Arg Leu Cys Leu Ser Asn Glu Glu Gln Ile Ile Ile His 
                1285                1290                1295


Asp Phe Ile Leu Glu Ala Thr Gln Asp Asp Tyr Val Leu Glu Val Arg 
            1300                1305                1310


His Phe Gln Cys Pro Lys Trp Pro Asn Pro Asp Ala Pro Ile Ser Ser 
        1315                1320                1325


Thr Phe Glu Leu Ile Asn Val Ile Lys Glu Glu Ala Leu Thr Arg Asp 
    1330                1335                1340


Gly Pro Thr Ile Val His Asp Glu Tyr Gly Ala Val Ser Ala Gly Met 
1345                1350                1355                1360


Leu Cys Ala Leu Thr Thr Leu Ser Gln Gln Leu Glu Asn Glu Asn Ala 
                1365                1370                1375


Val Asp Val Phe Gln Val Ala Lys Met Ile Asn Leu Met Arg Pro Gly 
            1380                1385                1390


Val Phe Thr Asp Ile Glu Gln Tyr Gln Phe Ile Tyr Lys Ala Met Leu 
        1395                1400                1405


Ser Leu Val Ser Thr Lys Glu Asn Gly Asn Gly Pro Met Thr Val Asp 
    1410                1415                1420


Lys Asn Gly Ala Val Leu Ile Ala Asp Glu Ser Asp Pro Ala Glu Ser 
1425                1430                1435                1440


Met Glu Ser Leu Val 
                1445


<210>  2260
<211>  9425
<212>  DNA
<213>  Homo sapiens

<400>  2260
acatgttact tcctgtatgg aggcatggcc agtttccagc cccgcgctct tcgttccttc     60

ccagcctgcg ccggagccac aactttcagg agcatggact gaaggcgccc tcgccccagc    120

gcccctctga gatcctttgt gttttcctcc gtttcctccg gccgtttcta ttttgggggg    180

ctctccgctc cccctgcctc tcccctcccc ttcccctctc gcaaacatgc ctccttcctt    240

cccggggccc tggaaggagc tgcctgcctg aagcccggag acgccgcgcc gcgctcagcc    300

ccgccgccgc ccgccggctc tcgggctgtg ctgcgctgcc gactcaagtt ggggatcctc    360

ggctgctcgc cgccgccgcc cgcggtccct gcctgcccca ggcccggggc atcgccgccg    420

gccgccgact ccgcgccctg cccgatcggc tctctccttt ttaaacggaa agcagccttt    480

ctccgccgag aggatcgtcc ccagcgtggc tctgcgttcc cggtcacttt ttgagatttt    540

ccggggggcg ctcggcggct tcccggattc caaggggact cgggccgccg agcgcggggg    600

gcccgtggag cgggcgagcc ggggaagcgc cccggcttag cggaggctcg cacggaggca    660

agaacttatt caacaagttt acctccctgc tttcctcttt tcgatgtgcg ttttcggaca    720

tgcggaggtt actggaaccg tgttggtgga ttttgttcct gaaaatcacc agttccgtgc    780

tccattatgt cgtgtgcttc cccgcgttga cagaaggcta cgttggggcc ctgcacgaga    840

atagacacgg cagcgcagtg cagatccgca ggcgcaaggc ttcaggcgac ccgtactggg    900

cctactctgg tgcctatggt cctgagcact gggtcacgtc tagtgtcagc tgtgggggcc    960

gtcaccagtc tcctattgac attttagacc agtatgcgcg tgttggggaa gaataccagg   1020

aactgcaact cgatggcttc gacaatgagt cttctaacaa aacctggatg aaaaacacag   1080

ggaaaacagt cgccatcctt ctgaaagacg actattttgt cagtggagct ggtctacctg   1140

gcagattcaa agctgagaag gtggaatttc actggggcca cagcaatggc tcagcgggct   1200

ctgaacacag catcaatggc aggaggtttc ctgttgagat gcagattttc ttttacaatc   1260

cagatgactt tgacagcttt caaaccgcaa tttctgagaa cagaataatc ggagccatgg   1320

ccatattttt tcaagtcagt ccgagggaca attctgcact ggatcctatt atccacgggt   1380

tgaagggtgt cgtacatcat gagaaggaga cctttctgga tcctttcgtc ctccgggacc   1440

tcctgcctgc atccctgggc agctattatc ggtacacagg ttccttgacc acaccaccgt   1500

gtagcgaaat agtggagtgg atagtcttcc ggagacccgt ccccatctct taccatcagc   1560

ttgaggcttt ttattccatc ttcaccacgg agcagcaaga ccatgtcaag tcggtggagt   1620

atctgagaaa taactttcga ccacagcagc gtctgcatga cagggtggtg tccaagtccg   1680

ccgtccgtga ctcctggaac cacgacatga cagacttctt agaaaaccca ctggggacag   1740

aagcctctaa agtttgcagc tctccaccca tccacatgaa ggtgcagcct ctgaaccaga   1800

cggcactgca ggtgtcctgg agccagccgg agactatcta ccacccaccc atcatgaact   1860

acatgatctc ctacagctgg accaagaatg aggacgagaa ggagaagacg tttacaaagg   1920

acagcgacaa agacttgaaa gccaccatta gccatgtctc acccgatagc ctttacctgt   1980

tccgagtcca ggccgtgtgt cggaacgaca tgcgcagcga ctttagccag acgatgctgt   2040

ttcaagctaa taccactcga atattccaag ggaccagaat agtgaaaaca ggagtgccca   2100

cagcgtctcc tgcctcttca gccgacatgg cccccatcag ctcggggtct tctacctgga   2160

cgtcctctgg catcccattc tcatttgttt ccatggcaac tgggatgggc ccctcctcca   2220

gtggcagcca ggccacagtg gcctcggtgg tcaccagcac gctgctcgcc ggcctggggt   2280

tcggcggtgg tggcatctcc tctttcccca gcactgtgtg gcccacgcgc ctcccgacgg   2340

ccgcctcagc cagcaagcag gcggctaggc cagtcctagc caccacagag gccttggctt   2400

ctccagggcc cgatggtgat tcgtcaccaa ccaaggacgg cgagggcacc gaggaaggag   2460

agaaggatga gaaaagcgag agtgaggatg gggagcggga gcacgaggag gatggagaga   2520

aggactccga aaagaaggag aagagtgggg tgacccacgc tgccgaggag cggaatcaga   2580

cggagcccag ccccacaccc tcgtctccta acaggactgc cgagggaggg catcagacta   2640

tacctgggca tgagcaggat cacactgccg tccccacaga ccagacgggc ggaaggaggg   2700

atgccggccc aggcctggac cccgacatgg tcacctccac ccaagtgccc cccaccgcca   2760

cagaggagca gtatgcaggg agtgatccca agaggcccga aatgccatct aaaaagccta   2820

tgtcccgcgg ggaccgattt tctgaagaca gcagatttat cactgttaat ccagcggaaa   2880

aaaacacctc tggaatgata agccgccctg ctccagggag gatggagtgg atcatccctc   2940

tgattgtggt atcagccttg accttcgtgt gcctcatcct tctcattgct gtgctcgttt   3000

actggagagg gtgtaacaaa ataaagtcca agggctttcc cagacgtttc cgtgaagtgc   3060

cttcttctgg ggagagagga gagaagggga gcagaaaatg ttttcagact gctcatttct   3120

atgtggaaga cagcagttca cctcgagtgg tccctaatga aagtatccct attattccta   3180

ttccggatga catggaagcc attcctgtca aacagtttgt caaacacatc ggtgagctct   3240

attctaataa ccagcatggg ttctctgagg attttgagga agtccagcgc tgtactgctg   3300

atatgaacat cactgcagag cattccaatc atccagaaaa caagcacaaa aacagataca   3360

tcaacatttt agcatatgat cacagtaggg tgaagttaag acctttacca ggaaaagact   3420

ctaagcacag cgactacatt aatgcaaact atgttgatgg ttacaacaaa gcaaaagcct   3480

acattgccac ccaaggacct ttgaagtcta catttgaaga tttctggagg atgatttggg   3540

aacaaaacac tggaatcatt gtgatgatta cgaaccttgt ggaaaaagga agacgaaaat   3600

gtgatcagta ttggccaaca gagaacagtg aggaatatgg aaacattatt gtcacgctga   3660

agagcacaaa aatacatgcc tgctacactg ttcgtcgttt ttcaatcaga aatacaaaag   3720

tgaaaaaggg tcagaaggga aatcccaagg gtcgtcagaa tgaaagggta gtgatccagt   3780

atcactatac acagtggcct gacatgggag ttcccgagta tgcccttcca gtactgactt   3840

tcgtgaggag atcctcagca gctcggatgc cagaaacggg ccctgtgttg gtgcactgca   3900

gtgctggtgt gggcagaaca ggcacctata ttgtaataga cagcatgctg caacagataa   3960

aagacaaaag cacagttaac gtcctgggat tcctgaagca tatcaggaca cagcgtaact   4020

acctcgtcca gactgaggag cagtacattt tcatccatga tgccttgttg gaagccattc   4080

ttggaaagga gactgaagta tcttcaaatc agctgcacag ctatgttaac agcatcctta   4140

taccaggagt aggaggaaag acacgactgg aaaagcaatt caagctggtc acacagtgta   4200

atgcaaaata tgtggaatgt ttcagtgctc agaaagagtg taacaaagaa aagaacagaa   4260

actcttcagt tgtgccatct gagcgtgctc gagtgggtct tgcaccattg cctggaatga   4320

aaggaacaga ttacattaat gcttcttata tcatgggcta ttataggagc aatgaattta   4380

ttataactca gcatcctctg ccacatacta cgaaagattt ctggcgaatg atttgggatc   4440

ataacgcaca gatcattgtc atgctgccag acaaccagag cttggcagaa gatgagtttg   4500

tgtactggcc aagtcgagaa gaatccatga actgtgaggc ctttaccgtc acccttatca   4560

gcaaagacag actgtgcctc tctaatgaag aacaaattat catccatgac tttatccttg   4620

aagctacaca ggatgactat gtcttagaag ttcggcactt tcagtgtccc aaatggccta   4680

acccagatgc ccccataagt agtacctttg aacttatcaa cgtcatcaag gaagaggcct   4740

taacaaggga tggtcccacc attgttcatg atgagtatgg agcagtttca gcaggaatgt   4800

tatgtgccct taccaccctg tcccagcaac tggagaatga aaatgctgtg gatgttttcc   4860

aggttgcaaa aatgatcaat cttatgaggc ctggagtatt cacagacatt gaacaatacc   4920

agttcatcta taaagcaatg cttagcttgg tcagcactaa agaaaatgga aatggtccca   4980

tgacagtaga caaaaatggt gctgttctta ttgcagatga atcagaccct gctgagagca   5040

tggagtccct agtgtgactg gaatcctgaa agggcactta atttgtaaac ttctgaagac   5100

tgagaacttt tttgaggcct tttttgccag actctaggtt atacaataac ccagttactt   5160

ttttacactg ataaaagttt tgatatttat tttttgccat tttatgtctt aatggtatcc   5220

tactgagcat ttgcacctct gttcatttca cacagtgaaa cgcaatttta cctagtttgc   5280

actatatgat cagtgttact gcctataatc ttatacaaca gcaaaccctg atgtgacatt   5340

ccatgacgac atacatgcta ctttttttta gttcaataca gtgaaggtct ttgttatgac   5400

agtgaatatt gcttttatta ttattattgc tgaagtggtt gcattctact agcaggcaat   5460

gctgtacttt tcttcagtcc tcctctcctt tttattttag gcactgttca atactgtatg   5520

ccttctgtat tttaatggag tggatagcat tgttttcttt tacagactag caggctactg   5580

ggacctaaaa aggtctgtta atgtcatggc cttgaaacag ttccatttat gctggttaag   5640

agatccctta agaagttaga aggcttaaga actgcttcat gtgaacatcc cttattagtt   5700

acaaagttat attcacagtt ttttaaaaat gtgtcaaaat aaaggataac tctgtattac   5760

agctttcaca gtagctatgt ggacaatgtg ttatttccat tttgactctc taaaatagct   5820

acatcctaaa atcagggcta tctttaacaa tagcaagata gcaatattat atacaactca   5880

gttatgagac cctttagtta ttctccatta atgcttctta gtttgtaata ccatacctca   5940

cagtaggtag aagaatgaaa acttctgcag gtgtgtaatt ttgaaactag tcctctaaaa   6000

attccctatt actcctatag caatctaata aaaactacct acatagttac tgttttcttt   6060

ccttctttgc caaatgtttt ataataaatc tcttaattac atacattttt ctacttaaga   6120

ttaaattgga aatactgtct tagcaaaagt cttgggacta tctaaactcc cacacataga   6180

taaatctgat ttggagagag aaatttaaaa tatttaatta aaggtgatac ccacattttc   6240

aagtttttaa aagagggaga tggctttgta tgcttttgtg tagtttagaa cagatacaca   6300

ttagtaaaag ataccaataa tcattagagc tcaaggaagt tattaggtgc agcctctgga   6360

gccatactca cgctgcagtg cataatggga aaattaggag cattaataag aaatttcagt   6420

agtgtttgta aggaaaataa gctacttact gagatctgtt tcttctattg catgtttgct   6480

tttgagggac agcttctgtc aaaagtgaaa tcatcaccag aactgggcct gttaggaaga   6540

atagggtttt atttactttt tatgtcaatt aacttcaaca aaaaggccac gctggctgct   6600

gtcatgccat ctgggtatgc attaaacatt aatgatgatc agcactgagg ttctatttat   6660

cttgatttgg ctttcataaa gtttgtcaga atggtgctgg aggaccagaa gtgctaagga   6720

gaaagaagct atgggccaag ttaaagaatt tgaatgcaaa ggccaggtca atggagtttt   6780

cataaactac ataatttacc agggtttatc tcatcttctc aatacataga tttaacaaca   6840

tggaatactc tgcttttcaa gagctgcgta agctagtcct gagataagat gttcaagaga   6900

gcatgctaag ttgcatgtgc tagatgagag acacctttac agcccctccg ctccaaccag   6960

aggtgacaca ggaagctctg taaagttcaa gtaaagcttg aacacaggaa cactacaact   7020

gccagatgct gaggagaatc aggaaagcaa tgagctagac tcttttttta gtcaattaag   7080

tgggttgttt tagatgtata gagtattgat atgagttaac actttttagt agatggcaaa   7140

gtgggcttga tgttcaaaag taatgttcga gttagggttc atggtccctt tctcagtaat   7200

tttttcttaa taaaagtaaa cactggttca aagacaaata gcaagtattc cctcctgtgc   7260

tatttataga gggctcaatt cgtagaaagg cataccctcc aatgcaattc tgtggctgtc   7320

ccttacagtg gtttcagaat cacgaaaaaa cagctagtaa ataggataga aacaataaaa   7380

gaaagagttt agaagttccc tgtgagcaat ctgtgtgtct tcagcgagct tgaaccaaag   7440

tcttcatatc ctgacccact gaattataag caattgctac ttgcccatct tgccaaagta   7500

gtccaaacac acttcaatga ggacagttat atttagcagg tcctcacccc tgcaagagac   7560

agcatatcct cactattatt attcatgtgt tattggcaaa aacatagctt gcatctttcc   7620

agaggcagag tttcaaagac agggttttct ttgagacata agcacattgc ttaagtacat   7680

aacaaggtta ttaacacttg cactcagggg aaaggaaata gctattgcaa attaatgtgt   7740

gcaacttaat aaaataagct gtttgtgtat atgaatttag ctctaggtaa gcaaaatgca   7800

cacatcatat aaaaataaat tgcaatgatc agaccaagtg gctgtgctgg acatcaaaga   7860

aaagacatgc tgttgccatc aggagaactc tttcttatat gcgatagcca agatatcttc   7920

tttaatatga aaaaagttaa tttctgaatt tcaaaaagag taagattagc taattggtct   7980

tcctaatttt tatgccttta gagtttttag tctattcaag tagaagagtc cagcgaggcc   8040

aaagaagggt tacggtgttc aagttctggt tgttggagtt tttagcccag agtgacatac   8100

tgaaatcagt aaataattat tttataatga cacagcacaa ctgccttgtt atgaattttt   8160

cttaaatgca tatatactgt atttaaaatt aaaatataga taccaattta ccaaagatac   8220

atattactaa ttctaagcaa aactaaaaaa aaaacccaac tcatcataat ttaagaatca   8280

aaatgtagtt tgtcttaaga atttagtggt tatactggaa atgcattttc aactcctatg   8340

ttctaaagtt tatgttcaaa tggtgccagt gaatttttat atgaagggaa aatgcctgct   8400

tttttttttt ttttaacaga tgtaatttca cttaaccctt tgcgctttcc cttagttgtc   8460

atttaacata caatactggc tttacttatc tctagaaaga agaaggcatg ctacaaatag   8520

gaaggaattg taataatgat atttggcctc tactttgtct tagctgttaa actgttttta   8580

gtatttttgt taaatatttg caaagggaag cattttctac agaggataat taatttcaag   8640

aaaaatatct tgagttttaa gaaataaaca tctccagaaa aggagaaagt cgattttata   8700

aaatgtcgca actctccaac atttggggta gtgactcctt ttttgttagg acatttgaaa   8760

ctagcaagca gccattgttt ctaaagaatt ctggcttcac attgactcat gtttctttca   8820

ctccattttg aaatagctaa aaatcattaa aactgtaaat attttgttgc ttgggtaagc   8880

atcttctggg aactttgtat ctatggtata taatcataga attttatatt ttcatataaa   8940

gctaattttt ttctagtttc aactccgtca tagttttttt tcctttttgt ggtggatatg   9000

tgaattcaac tttctgtgta ttgaagtagc aaaaaccatc tttacattcc aaaagaatcc   9060

aacatgtgtt atttctttga ggcagtgatt gtgaaagttg ggttttcttt ttaattccat   9120

tgaccatttg tgcaatagga attagacata attagtcact gaaaacattc gtcacattga   9180

cccatttgga aaaagtgtgc tttttttttt tttttaaatt tgttcagggg gaggggtttt   9240

gtaacctgaa atttttccct ttttcttctg tttaaactat atcaaatcat tctattatag   9300

tgttatttaa tatgtaaatt gtattgctat acataaaata aagtatggtt tttgatgtat   9360

tcagtagtgt tgagcatttc tatgaaaatg tctatatcca ataaaatagg ttactagtct   9420

ccctt                                                               9425


<210>  2261
<211>  1445
<212>  PRT
<213>  Homo sapiens

<400>  2261

Met Arg Arg Leu Leu Glu Pro Cys Trp Trp Ile Leu Phe Leu Lys Ile 
1               5                   10                  15


Thr Ser Ser Val Leu His Tyr Val Val Cys Phe Pro Ala Leu Thr Glu 
            20                  25                  30


Gly Tyr Val Gly Ala Leu His Glu Asn Arg His Gly Ser Ala Val Gln 
        35                  40                  45


Ile Arg Arg Arg Lys Ala Ser Gly Asp Pro Tyr Trp Ala Tyr Ser Gly 
    50                  55                  60


Ala Tyr Gly Pro Glu His Trp Val Thr Ser Ser Val Ser Cys Gly Gly 
65                  70                  75                  80


Arg His Gln Ser Pro Ile Asp Ile Leu Asp Gln Tyr Ala Arg Val Gly 
                85                  90                  95


Glu Glu Tyr Gln Glu Leu Gln Leu Asp Gly Phe Asp Asn Glu Ser Ser 
            100                 105                 110


Asn Lys Thr Trp Met Lys Asn Thr Gly Lys Thr Val Ala Ile Leu Leu 
        115                 120                 125


Lys Asp Asp Tyr Phe Val Ser Gly Ala Gly Leu Pro Gly Arg Phe Lys 
    130                 135                 140


Ala Glu Lys Val Glu Phe His Trp Gly His Ser Asn Gly Ser Ala Gly 
145                 150                 155                 160


Ser Glu His Ser Ile Asn Gly Arg Arg Phe Pro Val Glu Met Gln Ile 
                165                 170                 175


Phe Phe Tyr Asn Pro Asp Asp Phe Asp Ser Phe Gln Thr Ala Ile Ser 
            180                 185                 190


Glu Asn Arg Ile Ile Gly Ala Met Ala Ile Phe Phe Gln Val Ser Pro 
        195                 200                 205


Arg Asp Asn Ser Ala Leu Asp Pro Ile Ile His Gly Leu Lys Gly Val 
    210                 215                 220


Val His His Glu Lys Glu Thr Phe Leu Asp Pro Phe Val Leu Arg Asp 
225                 230                 235                 240


Leu Leu Pro Ala Ser Leu Gly Ser Tyr Tyr Arg Tyr Thr Gly Ser Leu 
                245                 250                 255


Thr Thr Pro Pro Cys Ser Glu Ile Val Glu Trp Ile Val Phe Arg Arg 
            260                 265                 270


Pro Val Pro Ile Ser Tyr His Gln Leu Glu Ala Phe Tyr Ser Ile Phe 
        275                 280                 285


Thr Thr Glu Gln Gln Asp His Val Lys Ser Val Glu Tyr Leu Arg Asn 
    290                 295                 300


Asn Phe Arg Pro Gln Gln Arg Leu His Asp Arg Val Val Ser Lys Ser 
305                 310                 315                 320


Ala Val Arg Asp Ser Trp Asn His Asp Met Thr Asp Phe Leu Glu Asn 
                325                 330                 335


Pro Leu Gly Thr Glu Ala Ser Lys Val Cys Ser Ser Pro Pro Ile His 
            340                 345                 350


Met Lys Val Gln Pro Leu Asn Gln Thr Ala Leu Gln Val Ser Trp Ser 
        355                 360                 365


Gln Pro Glu Thr Ile Tyr His Pro Pro Ile Met Asn Tyr Met Ile Ser 
    370                 375                 380


Tyr Ser Trp Thr Lys Asn Glu Asp Glu Lys Glu Lys Thr Phe Thr Lys 
385                 390                 395                 400


Asp Ser Asp Lys Asp Leu Lys Ala Thr Ile Ser His Val Ser Pro Asp 
                405                 410                 415


Ser Leu Tyr Leu Phe Arg Val Gln Ala Val Cys Arg Asn Asp Met Arg 
            420                 425                 430


Ser Asp Phe Ser Gln Thr Met Leu Phe Gln Ala Asn Thr Thr Arg Ile 
        435                 440                 445


Phe Gln Gly Thr Arg Ile Val Lys Thr Gly Val Pro Thr Ala Ser Pro 
    450                 455                 460


Ala Ser Ser Ala Asp Met Ala Pro Ile Ser Ser Gly Ser Ser Thr Trp 
465                 470                 475                 480


Thr Ser Ser Gly Ile Pro Phe Ser Phe Val Ser Met Ala Thr Gly Met 
                485                 490                 495


Gly Pro Ser Ser Ser Gly Ser Gln Ala Thr Val Ala Ser Val Val Thr 
            500                 505                 510


Ser Thr Leu Leu Ala Gly Leu Gly Phe Gly Gly Gly Gly Ile Ser Ser 
        515                 520                 525


Phe Pro Ser Thr Val Trp Pro Thr Arg Leu Pro Thr Ala Ala Ser Ala 
    530                 535                 540


Ser Lys Gln Ala Ala Arg Pro Val Leu Ala Thr Thr Glu Ala Leu Ala 
545                 550                 555                 560


Ser Pro Gly Pro Asp Gly Asp Ser Ser Pro Thr Lys Asp Gly Glu Gly 
                565                 570                 575


Thr Glu Glu Gly Glu Lys Asp Glu Lys Ser Glu Ser Glu Asp Gly Glu 
            580                 585                 590


Arg Glu His Glu Glu Asp Gly Glu Lys Asp Ser Glu Lys Lys Glu Lys 
        595                 600                 605


Ser Gly Val Thr His Ala Ala Glu Glu Arg Asn Gln Thr Glu Pro Ser 
    610                 615                 620


Pro Thr Pro Ser Ser Pro Asn Arg Thr Ala Glu Gly Gly His Gln Thr 
625                 630                 635                 640


Ile Pro Gly His Glu Gln Asp His Thr Ala Val Pro Thr Asp Gln Thr 
                645                 650                 655


Gly Gly Arg Arg Asp Ala Gly Pro Gly Leu Asp Pro Asp Met Val Thr 
            660                 665                 670


Ser Thr Gln Val Pro Pro Thr Ala Thr Glu Glu Gln Tyr Ala Gly Ser 
        675                 680                 685


Asp Pro Lys Arg Pro Glu Met Pro Ser Lys Lys Pro Met Ser Arg Gly 
    690                 695                 700


Asp Arg Phe Ser Glu Asp Ser Arg Phe Ile Thr Val Asn Pro Ala Glu 
705                 710                 715                 720


Lys Asn Thr Ser Gly Met Ile Ser Arg Pro Ala Pro Gly Arg Met Glu 
                725                 730                 735


Trp Ile Ile Pro Leu Ile Val Val Ser Ala Leu Thr Phe Val Cys Leu 
            740                 745                 750


Ile Leu Leu Ile Ala Val Leu Val Tyr Trp Arg Gly Cys Asn Lys Ile 
        755                 760                 765


Lys Ser Lys Gly Phe Pro Arg Arg Phe Arg Glu Val Pro Ser Ser Gly 
    770                 775                 780


Glu Arg Gly Glu Lys Gly Ser Arg Lys Cys Phe Gln Thr Ala His Phe 
785                 790                 795                 800


Tyr Val Glu Asp Ser Ser Ser Pro Arg Val Val Pro Asn Glu Ser Ile 
                805                 810                 815


Pro Ile Ile Pro Ile Pro Asp Asp Met Glu Ala Ile Pro Val Lys Gln 
            820                 825                 830


Phe Val Lys His Ile Gly Glu Leu Tyr Ser Asn Asn Gln His Gly Phe 
        835                 840                 845


Ser Glu Asp Phe Glu Glu Val Gln Arg Cys Thr Ala Asp Met Asn Ile 
    850                 855                 860


Thr Ala Glu His Ser Asn His Pro Glu Asn Lys His Lys Asn Arg Tyr 
865                 870                 875                 880


Ile Asn Ile Leu Ala Tyr Asp His Ser Arg Val Lys Leu Arg Pro Leu 
                885                 890                 895


Pro Gly Lys Asp Ser Lys His Ser Asp Tyr Ile Asn Ala Asn Tyr Val 
            900                 905                 910


Asp Gly Tyr Asn Lys Ala Lys Ala Tyr Ile Ala Thr Gln Gly Pro Leu 
        915                 920                 925


Lys Ser Thr Phe Glu Asp Phe Trp Arg Met Ile Trp Glu Gln Asn Thr 
    930                 935                 940


Gly Ile Ile Val Met Ile Thr Asn Leu Val Glu Lys Gly Arg Arg Lys 
945                 950                 955                 960


Cys Asp Gln Tyr Trp Pro Thr Glu Asn Ser Glu Glu Tyr Gly Asn Ile 
                965                 970                 975


Ile Val Thr Leu Lys Ser Thr Lys Ile His Ala Cys Tyr Thr Val Arg 
            980                 985                 990


Arg Phe Ser Ile Arg Asn Thr Lys Val Lys Lys Gly Gln Lys Gly Asn 
        995                 1000                1005


Pro Lys Gly Arg Gln Asn Glu Arg Val Val Ile Gln Tyr His Tyr Thr 
    1010                1015                1020


Gln Trp Pro Asp Met Gly Val Pro Glu Tyr Ala Leu Pro Val Leu Thr 
1025                1030                1035                1040


Phe Val Arg Arg Ser Ser Ala Ala Arg Met Pro Glu Thr Gly Pro Val 
                1045                1050                1055


Leu Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Val 
            1060                1065                1070


Ile Asp Ser Met Leu Gln Gln Ile Lys Asp Lys Ser Thr Val Asn Val 
        1075                1080                1085


Leu Gly Phe Leu Lys His Ile Arg Thr Gln Arg Asn Tyr Leu Val Gln 
    1090                1095                1100


Thr Glu Glu Gln Tyr Ile Phe Ile His Asp Ala Leu Leu Glu Ala Ile 
1105                1110                1115                1120


Leu Gly Lys Glu Thr Glu Val Ser Ser Asn Gln Leu His Ser Tyr Val 
                1125                1130                1135


Asn Ser Ile Leu Ile Pro Gly Val Gly Gly Lys Thr Arg Leu Glu Lys 
            1140                1145                1150


Gln Phe Lys Leu Val Thr Gln Cys Asn Ala Lys Tyr Val Glu Cys Phe 
        1155                1160                1165


Ser Ala Gln Lys Glu Cys Asn Lys Glu Lys Asn Arg Asn Ser Ser Val 
    1170                1175                1180


Val Pro Ser Glu Arg Ala Arg Val Gly Leu Ala Pro Leu Pro Gly Met 
1185                1190                1195                1200


Lys Gly Thr Asp Tyr Ile Asn Ala Ser Tyr Ile Met Gly Tyr Tyr Arg 
                1205                1210                1215


Ser Asn Glu Phe Ile Ile Thr Gln His Pro Leu Pro His Thr Thr Lys 
            1220                1225                1230


Asp Phe Trp Arg Met Ile Trp Asp His Asn Ala Gln Ile Ile Val Met 
        1235                1240                1245


Leu Pro Asp Asn Gln Ser Leu Ala Glu Asp Glu Phe Val Tyr Trp Pro 
    1250                1255                1260


Ser Arg Glu Glu Ser Met Asn Cys Glu Ala Phe Thr Val Thr Leu Ile 
1265                1270                1275                1280


Ser Lys Asp Arg Leu Cys Leu Ser Asn Glu Glu Gln Ile Ile Ile His 
                1285                1290                1295


Asp Phe Ile Leu Glu Ala Thr Gln Asp Asp Tyr Val Leu Glu Val Arg 
            1300                1305                1310


His Phe Gln Cys Pro Lys Trp Pro Asn Pro Asp Ala Pro Ile Ser Ser 
        1315                1320                1325


Thr Phe Glu Leu Ile Asn Val Ile Lys Glu Glu Ala Leu Thr Arg Asp 
    1330                1335                1340


Gly Pro Thr Ile Val His Asp Glu Tyr Gly Ala Val Ser Ala Gly Met 
1345                1350                1355                1360


Leu Cys Ala Leu Thr Thr Leu Ser Gln Gln Leu Glu Asn Glu Asn Ala 
                1365                1370                1375


Val Asp Val Phe Gln Val Ala Lys Met Ile Asn Leu Met Arg Pro Gly 
            1380                1385                1390


Val Phe Thr Asp Ile Glu Gln Tyr Gln Phe Ile Tyr Lys Ala Met Leu 
        1395                1400                1405


Ser Leu Val Ser Thr Lys Glu Asn Gly Asn Gly Pro Met Thr Val Asp 
    1410                1415                1420


Lys Asn Gly Ala Val Leu Ile Ala Asp Glu Ser Asp Pro Ala Glu Ser 
1425                1430                1435                1440


Met Glu Ser Leu Val 
                1445


<210>  2262
<211>  2084
<212>  DNA
<213>  Homo sapiens

<400>  2262
aggattcctc atgggatgac aaggccttgc tccagggatg atgtttccca ctgtaggaga     60

acagctactg tctttgatga actgagtcta cagggctatt gaagggtctt gctgtgctgc    120

ccagcctgga gtgtggtggt gcgatcatgg ctcactgaag cctccactta caactcctgg    180

actcaagtga tcctcccacc tgagcctcct gagtagctag gactataggc acttggcacc    240

acacctggca aatttttttt atcataggat ctcgctacat tggccaggct ggtctcaaac    300

ttctggcccc aagtgatttt cccacctctg cctcccaaag tgctgagact acagtctggc    360

ccttcatgat ctctagatat taccaaaagt cccagagaaa tgagtgcatg gatggcttaa    420

tgacaaccca ctttcttctc tggaagaaag aacttagtac agccctacca gaaggtggga    480

tggcaatgcc atcttcagac ttgagtgttg gggaggcctt ttctgctaac caacagcaaa    540

tgttttacaa gagaaacagg acacacagta gatgaaggca gccatggaaa atctgtatga    600

attatccact ctgttgatct gtgcttaaaa tatagaaggg aaagtgaaga ataaaaatgt    660

gtccatgagc atcccacctg gcttgcatcc agattgaaca atttgaatgc taagagcagg    720

attttgatag tatggcagac attgctcatt gctcagccaa cccattctcc cctttgtcct    780

tactaacaac atcctgattt tgtgtaggca acaatgctcc cagctaaaat tacctacttt    840

accagactcc tatgcagtta gaggtggccc agtaaccctg gcaaataaga tgcatgcagg    900

cattactgga ctgagcttcc aaaaacagct tttaaaaggg gcaagctcaa ctgcatgacc    960

ctttgggctt ttgaacctct ttacctggaa atgagaccta aagctaaaaa tgaaacaact   1020

gtcttgttat catgaggtga ctatcatgaa gatgaaaacc tccacaccaa ataagtggaa   1080

agaaaagttg gaaagaggtg gagagaatga ctcaatcttt gatgtatcag tgctgcattg   1140

cctccctcaa aatgtctcaa ctgttttatg cagctgagca aattcgtgat ctcaaacagc   1200

aactcaagca actccaggaa agaaaaaaaa ttgaccactg gaggagatac ctaagataat   1260

cctggtgata ctttcggtgc tacaagaaaa aaataatcct cgcacccaag aagaaacaat   1320

gaaaccttat ttttcatgta aatttctact cctgtttggt tcaagcattt gaactgttgc   1380

ataagatttt tttgagtgcc gctgagaaaa gtattatcaa tctagaatgc accagaaaga   1440

aagcagcaga aagattacaa acagcttttc taaacccttg tccagcattt accagaaaga   1500

gcagcatgaa ttaacaaaag cagaaatttt agttaaaaaa aaaaagcaac tcaactctga   1560

ttcctgagac atataataca ggacgtctat cgcccattta ccctcatcca actcaaatgg   1620

ctaccaaact ctaaaattag cagggcatgt cgggaagact tcttattcct tgtattacag   1680

atctgttgac gtgtcagtag cattttcctt tgcaagttat aaaatttcct ttccccagtc   1740

ttcaaatagg cacttccccc tccccaaagt ctcttttgtc accaactgcc ataacccacc   1800

aatcagggaa acaaatttca gttcataaaa gaaaaccatg ggtgacctac tgaggaccac   1860

agtttcattt ccataacaaa gactgacata caacccatgc ccaaagtctg gaacagctat   1920

gaataactgt ggctgaatag tctattttct gttgggattc atatcaaact ctatatttga   1980

acttgagata tcagaacttt tgtattataa tacataaaac ctaggtagtg agtttgaatt   2040

gtctgcattt attctccatg ggtaataaaa actcattgtt tctc                    2084


<210>  2263
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  2263

Met Ile Ser Arg Tyr Tyr Gln Lys Ser Gln Arg Asn Glu Cys Met Asp 
1               5                   10                  15


Gly Leu Met Thr Thr His Phe Leu Leu Trp Lys Lys Glu Leu Ser Thr 
            20                  25                  30


Ala Leu Pro Glu Gly Gly Met Ala Met Pro Ser Ser Asp Leu Ser Val 
        35                  40                  45


Gly Glu Ala Phe Ser Ala Asn Gln Gln Gln Met Phe Tyr Lys Arg Asn 
    50                  55                  60


Arg Thr His Ser Arg 
65


<210>  2264
<211>  2401
<212>  DNA
<213>  Homo sapiens

<400>  2264
tcccgctgct cctcctccgc ctccttcccc tgcccgcgcc cgccctactg ccccgtgccg     60

agtttcctgt ttaagatggc gtcccccgta gcagcgcagg ccgggaagct tctgcgagcc    120

ctagcgctgc ggccccgctt cctggcggcc gggtcccagg cagttcaatt aacctccaga    180

agatggctga acctgcagga ataccagagc aagaaactga tgtctgacaa cggagtgaga    240

gttcaaagat tctttgtagc agacactgca aatgaagctc tcgaggctgc taagagacta    300

aatgcaaaag aaattgtttt aaaagcccag atcttagctg gaggaagagg aaaaggtgtc    360

ttcaatagtg gtttgaaagg aggtgttcat ttaacaaaag accctaatgt tgtgggacag    420

ctggctaaac agatgattgg gtacaatcta gcgacaaaac aaactccaaa agaaggtgtg    480

aaagttaaca aggtgatggt tgctgaagcc ttggatattt ccagagaaac ctacctggca    540

attctgatgg accggtcctg caatggcccc gtgctggtgg gcagccccca ggggggcgtc    600

gacattgaag aggtggctgc ttcaaacccg gagctcattt ttaaggagca aattgacatt    660

tttgaaggaa taaaggacag ccaagctcag cggatggccg aaaatctagg cttcgttggg    720

cctttgaaaa gccaggctgc agatcaaatt acgaagctgt ataatctctt cctgaaaatt    780

gatgctactc aggtggaagt gaatcccttt ggtgaaactc cagaaggaca agttgtctgt    840

tttgatgcca agataaactt tgatgacaac gcagaattcc gacaaaaaga catatttgct    900

atggacgaca aatcagagaa tgagcccatt gaaaatgaag ctgccaaata tgatctaaaa    960

tacataggac tagatgggaa cattgcctgc tttgtgaatg gtgctgggct cgccatggct   1020

acttgtgata tcattttcct taatggtggg aagccagcca acttcttgga tcttggaggt   1080

ggtgtaaagg aagctcaagt atatcaagca ttcaaattgc tcacagctga tcctaaggtt   1140

gaagccatcc ttgtcaatat atttggtggt atcgtcaact gtgccatcat tgccaatggg   1200

atcaccaaag cctgccggga gctagaactc aaggtgcccc tggtggtccg gcttgaagga   1260

accaacgtcc aagaggccca gaagatactc aacaacagcg gactccccat tacttcagcc   1320

attgacctgg aggatgcagc caagaaggct gtggccagtg tggccaagaa gtgatgtctt   1380

tgtcctgatc caatggagaa agaaagccat ttttccgtaa aaagggatgg ttcatcattg   1440

tgaaagaaat ggttatctca ttggggaaga aaaggggagg gggaaggcaa gaatcactga   1500

aaaatcttaa atctgtgttt tctggaataa gatatctaga cagcctaaat ctgattttgg   1560

tctttataaa aataatatct tgtgttctca tacttttctg tcactgtaag cctgcccagt   1620

aggcagtgtt ttgcagactt tggggagtgg tctatgtggc caaatattgt gtgtatagac   1680

agaatttgaa atcaagtcct gcttcattta caagaatttt ggtgggcatc taatcctaca   1740

taatgaaaaa gaaaaacaga ccatttaaaa actcagacaa gattatattt aatatattaa   1800

ttactaaaaa ggcataagat tacactgaac atattagcta ctaaaaaggc actgctaaga   1860

cattcaagca aatagctatt acacactact gcagatttta caggtttcta attctaacat   1920

atgtttgaaa aatccgtgag tattccaaaa tatatttaat aatggaatat ctgcattaat   1980

ataccatcca tgtgttttta ccatttgcct taatattgaa tatactgttt acctcacact   2040

aaaaagaaaa ccagaagcct tatttgtgat tttgggagtg gaagcttcca tttttgtgtc   2100

aaaaatgaat cctgattctt atggaaatct ctgttattaa gatatttcaa gatgagacaa   2160

cactgaagat caaattgtgt ttagtatcac tatcttctct cctcgtttct ctcttactcc   2220

tcatcctccc agaatctacc agtttatggt agaaagatgg gaaccttatt tgaatgtgtt   2280

ttttttttcc atgatgtcca attttgttgt gggaaaggat ttggataaaa tttttgttta   2340

aattttggta gatttttatc tatacaaatt taaataaaat tatgttttgt aagctgtaag   2400

a                                                                   2401


<210>  2265
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  2265

Met Ala Ser Pro Val Ala Ala Gln Ala Gly Lys Leu Leu Arg Ala Leu 
1               5                   10                  15


Ala Leu Arg Pro Arg Phe Leu Ala Ala Gly Ser Gln Ala Val Gln Leu 
            20                  25                  30


Thr Ser Arg Arg Trp Leu Asn Leu Gln Glu Tyr Gln Ser Lys Lys Leu 
        35                  40                  45


Met Ser Asp Asn Gly Val Arg Val Gln Arg Phe Phe Val Ala Asp Thr 
    50                  55                  60


Ala Asn Glu Ala Leu Glu Ala Ala Lys Arg Leu Asn Ala Lys Glu Ile 
65                  70                  75                  80


Val Leu Lys Ala Gln Ile Leu Ala Gly Gly Arg Gly Lys Gly Val Phe 
                85                  90                  95


Asn Ser Gly Leu Lys Gly Gly Val His Leu Thr Lys Asp Pro Asn Val 
            100                 105                 110


Val Gly Gln Leu Ala Lys Gln Met Ile Gly Tyr Asn Leu Ala Thr Lys 
        115                 120                 125


Gln Thr Pro Lys Glu Gly Val Lys Val Asn Lys Val Met Val Ala Glu 
    130                 135                 140


Ala Leu Asp Ile Ser Arg Glu Thr Tyr Leu Ala Ile Leu Met Asp Arg 
145                 150                 155                 160


Ser Cys Asn Gly Pro Val Leu Val Gly Ser Pro Gln Gly Gly Val Asp 
                165                 170                 175


Ile Glu Glu Val Ala Ala Ser Asn Pro Glu Leu Ile Phe Lys Glu Gln 
            180                 185                 190


Ile Asp Ile Phe Glu Gly Ile Lys Asp Ser Gln Ala Gln Arg Met Ala 
        195                 200                 205


Glu Asn Leu Gly Phe Val Gly Pro Leu Lys Ser Gln Ala Ala Asp Gln 
    210                 215                 220


Ile Thr Lys Leu Tyr Asn Leu Phe Leu Lys Ile Asp Ala Thr Gln Val 
225                 230                 235                 240


Glu Val Asn Pro Phe Gly Glu Thr Pro Glu Gly Gln Val Val Cys Phe 
                245                 250                 255


Asp Ala Lys Ile Asn Phe Asp Asp Asn Ala Glu Phe Arg Gln Lys Asp 
            260                 265                 270


Ile Phe Ala Met Asp Asp Lys Ser Glu Asn Glu Pro Ile Glu Asn Glu 
        275                 280                 285


Ala Ala Lys Tyr Asp Leu Lys Tyr Ile Gly Leu Asp Gly Asn Ile Ala 
    290                 295                 300


Cys Phe Val Asn Gly Ala Gly Leu Ala Met Ala Thr Cys Asp Ile Ile 
305                 310                 315                 320


Phe Leu Asn Gly Gly Lys Pro Ala Asn Phe Leu Asp Leu Gly Gly Gly 
                325                 330                 335


Val Lys Glu Ala Gln Val Tyr Gln Ala Phe Lys Leu Leu Thr Ala Asp 
            340                 345                 350


Pro Lys Val Glu Ala Ile Leu Val Asn Ile Phe Gly Gly Ile Val Asn 
        355                 360                 365


Cys Ala Ile Ile Ala Asn Gly Ile Thr Lys Ala Cys Arg Glu Leu Glu 
    370                 375                 380


Leu Lys Val Pro Leu Val Val Arg Leu Glu Gly Thr Asn Val Gln Glu 
385                 390                 395                 400


Ala Gln Lys Ile Leu Asn Asn Ser Gly Leu Pro Ile Thr Ser Ala Ile 
                405                 410                 415


Asp Leu Glu Asp Ala Ala Lys Lys Ala Val Ala Ser Val Ala Lys Lys 
            420                 425                 430


<210>  2266
<211>  546
<212>  DNA
<213>  Homo sapiens

<400>  2266
tctccctgtg gtctttcccc agctccaccg gcagccctcc ctaaggactc ctgcgagaca     60

aagacagaaa tggcttccct gaggactgag agtggttaca gggctcttcc tgctgcttcc    120

tctactcctg tatttcactt ggctctctaa atttgtttca gctccagagc ccagtgcagc    180

tgaaatccta gaagacctca caactgtgtt aaattttcac agctgaccac ttaaaggcag    240

ttctcttcaa ataagagagt ctcactctct cacccaggct ggagtgcggt ggcacgatct    300

cagctcactg caacatctgc ctcccaggtt caagagattc tcctgcctca cttacataga    360

tgagtttgat aacagtcaag ctgaaactaa aaagacgcag cttgactgac acagagatcc    420

tgaataagag actctttgga tactgaaaag tctcttaaat aagaaatgct ggtgtaaggt    480

gttcagaaga caatggagaa aaaatggaaa tactgtgctg tctattacat catccagata    540

catttt                                                               546


<210>  2267
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  2267

Pro Leu Lys Gly Ser Ser Leu Gln Ile Arg Glu Ser His Ser Leu Thr 
1               5                   10                  15


Gln Ala Gly Val Arg Trp His Asp Leu Ser Ser Leu Gln His Leu Pro 
            20                  25                  30


Pro Arg Phe Lys Arg Phe Ser Cys Leu Thr Tyr Ile Asp Glu Phe Asp 
        35                  40                  45


Asn Ser Gln Ala Glu Thr Lys Lys Thr Gln Leu Asp 
    50                  55                  60


<210>  2268
<211>  6049
<212>  DNA
<213>  Homo sapiens

<400>  2268
ctgttctggc cttgaaaatg atccttctta aaaggatttt cctccttcct caagggaaag     60

aaaacctatt gatataaaac ttcacttccc attcagtttc ccctgctaaa tgccactcca    120

gtagagactg agtgttgata aatacagggg aaggaaaaag tcgtaagctg agcctggtca    180

cattgcccct tgtgatatcg ttttattttt aacttcgcaa cacttggact atttctgttg    240

aagttttctc tcctttccct gccttcccaa cagaacgctg tcctctactg cagctgatgc    300

aacccagcca cctcccggca atccgcttac ttgcaatcaa gggttcaggt gcaagcagat    360

gctgactcag cctgttccat taagagctaa gaagcaagaa gaaattgggg cgccatgggg    420

aaagcccgca gatccccgcc agggcaccac aggcattgtg agggatgctt caaccgccac    480

tgccacattc ctgtggaacc caacacctcc tgcctggtaa taagctgcca cctgctctgt    540

ggtgccacct tccacatgtg caaagaggca gagcaccagc tcctctgccc tttagagcag    600

gttccgtgcc tcaactccga atatggctgc cctctgtcca tgtcccgcca caaactggcc    660

aagcacctgc aggtgtgccc cgccagcgtg gtctgctgct ccatggagtg gaaccgctgg    720

ccaaatgtgg actctgaaac cacccttcat gaaaacatca tgaaagagac ccccagtgag    780

gagtgtttgg acacagccct ggccctgcag gatcagaagg tcctcttcag atccttgaaa    840

atggtggaac ttttcccaga aactagagag gctactgagg aggaaccaac tatgaatggt    900

gaaaccagtg tggaggaaat gggaggagca gtgggtggag tggatatcgg tttggtacca    960

catggtctgt cagcaactaa tggggagatg gcagagctaa gtcaagaaga acgggaggtg   1020

ctagccaaaa ccaaagaagg gatggacctg gtcaagtttg gccagtggga aaatattttc   1080

agcaaagagc acgcagcctc tgctttaaca aattcatcag cgagctgtga gagcaagaac   1140

aagaatgact ccgagaaaga acagatttcc agtggccata acatggtaga aggagagggc   1200

gctcccaaaa agaaagaacc acaggaaaat cagaagcagc aggacgttcg tacagccatg   1260

gaaaccacag ggcttgcccc ttggcaggat ggtgttctgg aaagactgaa aacagctgtg   1320

gatgcaaagg actataacat gtatctagtg cacaatgggc ggatgctgat acactttggt   1380

cagatgcctg cttgtacacc caaggagaga gactttgttt atggcaagct ggaggctcag   1440

gaagttaaga ctgtttacac cttcaaagtt cctgtgagct actgtggaaa gcgagctcga   1500

cttggagatg ccatgttgag ttgtaagcca agtgaacaca aggcagtgga tacttcagat   1560

ttggggatca ctgtggagga cctgcccaaa tcagatctca tcaagaccac cctccagtgt   1620

gctttggaaa gagaactcaa aggccacgtc atctctgaat ccagaagcat tgatggactg   1680

ttcatggatt ttgccacaca aacatacaac tttgagccag aacagttttc ctctgggaca   1740

gtgctggctg acctaaccgc tgccacccca gggggactcc acgtggagct ccacagcgag   1800

tgtgtgacca ggagacacaa caaaagcagc tctgccttca ctttcacttg caacaaattc   1860

ttcaggaggg atgagttccc cctgcacttc aagaatgtcc acacagacat tcagtcatgt   1920

ctcaatggct ggttccagca tcgatgcccc ctcgcctact tgggatgtac atttgttcaa   1980

aaccatttcc gtcccccagg gcaaaaggca aaagtaatct atagccagga gctcaagacc   2040

tttgccatta agccggaggt tgctccagag ctgagcgagg gaaggaagaa caaccatctt   2100

ttgggtcatg gaggaaaaag ccagaattct ttaaccagcc tgcccctgga gattttgaag   2160

tacattgctg ggttcttgga cagcgtcagc ctggcccagc tctcccaggt gtctgtgctg   2220

atgaggaata tctgtgccac tttgttacaa gagagaggaa tggtcctttt gcaatggaag   2280

aaaaagaggt attcccatgg aggcacctcc tggagagtcc acagagagat ctggcagttc   2340

agcagcctct tctccaaaat caagagctgg gagtttaatg aagtcacctc catgtctgag   2400

cacctgaagt cctgtccttt caacattgta gagcacaaaa ctgacccgat tcttttgact   2460

agcatgtgtc agccccgtga gcaggcccga gagagcttag tctccacctt tagaatcaga   2520

ccacgaggaa gatacgtctc ctaaaaattc agatgccact cgatgcaccc ttcttggatt   2580

tcttctcgga gttcctgaag taggacagag tgtgtggttt tgaggactcc cttctgtaaa   2640

ctgcctattt gcttatcggg gtgtattgga acacgcaatg tccttcgaaa cctcaacacg   2700

aggcctaaga atttcctaag ccatgtcttg taccatagtg ccacattgat gacttgtttc   2760

cttttttctt ttcttttctt ttcttttttc tttctttcta aaatagattg gtctgagaag   2820

aaaataagta atttgaggcc atttggaaga tgggcccaat ttcttaagtg atgagagagc   2880

acgaaattcc ataaccagta caggcctgtg cttttacatg ggctttttag ttcacaaagc   2940

actttcaaat ttatgggaca ggaaatgcag gatgggactc cccagggaac gcagggtgaa   3000

gggaacaaag ctggaggctc tggagctggg tctgttttga cggtcaagtc cagggctcat   3060

tttggttatt ctactgcctc taggccaggg tagtcctaac acagcctgac ataggagagc   3120

ccctggctga gcatggcagc cttgaagaca ccacaggcca aaacatgagg ggcagaaatg   3180

ggatcacaga gtctgttgct agaatcttgg caacatacag caggaaagcc ttgataaatc   3240

gggagtccaa aggagacacc atatttatgg agaacattag gacaaaaagt caccaactta   3300

ctttgtaaca ttttaataat gacttaaggg tcaagatttt tttcttctga aaattatgtt   3360

ctgagttagg cagaacatag ccatggccct gggccaccct gtgctatctg aaatgacctc   3420

aatacactaa tgccaacctc agcgtcatgc cagaatgcac agggcagccc agggagatca   3480

cacctttggc aaagtccaga caaggcccac tgcagttcct atggcgccag tcaccagctc   3540

ctagacagca cttgggtacc ccattggggt cttggagagg aagacatgtg aacataacgg   3600

ctccctgaaa ttgctcctac ccatccatat ttctggtcat gctttcagtc tgacaaaaat   3660

ggatgatact gctgtttttg gtaacaaaca gtgaatattc ataagaacaa aagtaaaaga   3720

aaaaaagaca cagtagaaac tggcatcccc taaagcaggg cttcttagcc ttggaactat   3780

tgacattttt aaatggataa ttcttttttt ttttttctag gtggggaggg gatggagttc   3840

actcttgttg cccaggctgg agcgcaatga catgatctcg gctcaccgca acctccgcct   3900

cctgggttca agcgattctc ctgcctcagc ctcccgagta gctgggatta ctcgcctggc   3960

taattttgta tttttagtag agacgggctt tctccatgtt gttcaggctg gtctcaaact   4020

cccgacctca ggtgactcgc ccgccttggc cttccaaagt gctgggttta caggtgtgag   4080

ccactgcgcc ctgcctgaac tggataattc tttgttgcaa gggactgttc tgtgtactac   4140

aggatacttg gcagcatcct tggcctatcc attaaatgtc agtagcaccc ccacagtggc   4200

aacaatcaaa aatgtcacca gacattgcta aatattgggg agcaaaatgg ctccccgttg   4260

aaaatcccta aaggatgtca tactagtgac aataagttag gatatgctta ttttttagta   4320

cagcaaaatc ttatcgcaca tagctatcca caatagttat gatttaatgc agctctttat   4380

ttatgaaata ggttttagac atgtggtgat tttaagttgg gaaccagaag gaaatgattc   4440

gtttggtatg gcttcatgtc cttcagccac ccccaagaat gtatcctttc agctctcttt   4500

ggttatacct gaagccagga gcgttgagtt attagccttg tgtttatatt cctctcactg   4560

taattggtgt cattttccca gcagtcctag cagtcctcaa gcaagtggga aatcggaaaa   4620

gaaaaggaca ggcattgtag ggaagcagag gataaagaat ttagccaaca aaagaaacaa   4680

tctagtcaat ctgggtgctt ttatttcctg ggttctctct aaacatggct cagagctggt   4740

gtagatgaag taggtgaaac ctctgaaaag agtctagaag gcagtagagc aagtcccaga   4800

ccagaaacat gctcatcttt tcatcgtaat gtgccactcg gtactatttg gtaatgtcac   4860

tctatttttc ctaatcccat cctttggttt gtatttcata tttgtatata aggcaccatt   4920

ttctaaaaat atgactaggg tgtgacctaa ggttttattc tgtgaagatg agtaactgga   4980

aagaagctaa cactgcagtg ggaaggaagg aagagagttg tccaggtggt agttcgacgt   5040

gttttgaatc tagtccttcc tacatggagg ataaaagctc ctaaagtcca ctctgggttt   5100

gtgattttaa tagaaataga aagggaaact atagaccaat ggagatgaaa atcaggggct   5160

atcgacagat ggaggagaaa taaggtgcta catagagaaa ggaagagggc agaaggcttt   5220

cccttcccaa actgggtgag ctggggaagc cttggttcag gagagtggca ctgcccacaa   5280

ctgctttgtg ggttgtgcac ttccagccgc actctccccc tccagttgct gccttcagag   5340

ccgtactgaa gcacgagctt caataagaca agcacacttc atagtgagag ggcagcggta   5400

ccaaagcctt tcagagagac tatggattag acagaaatga tttgtgagag gaagctggag   5460

tgaacagcat gaacagcgag tgttacctga cagaggcaag acagctagaa gtggcttcag   5520

atttagaaac agctgagggg agcaaagacg gactgtgtac acagggaggg aggatgtcta   5580

tgggcagagc ccttggtgag tatcatcacc aagaaaggca gtccagagta gagatcagcc   5640

gaatatggag gctgaggtct gtagaactgg gccagagagg accttactgc cttagtagca   5700

taagggtctg gaaaagaagt ttctatctca caacaaagga aaaagtgaaa agcaaggtgg   5760

aacttgaaga tacgtcacga aaatcactat aaaagtctga tttatgtgtg atgtcaaatc   5820

aaactgaaat gaagaatgag attgagtata tctgtggtga ctgacctctg tatactagaa   5880

acctcaacat ctctagaaga ggaaataaaa gctgctttgc actctgaaag gctaattggg   5940

tgaatcttat aagttaggtc tagagacaga tgtgtgattc acaggcatag aagttgtcgc   6000

tgaaaccaag tgtgtatcat gaagaaagac cagagcacaa gcctgagac               6049


<210>  2269
<211>  709
<212>  PRT
<213>  Homo sapiens

<400>  2269

Met Gly Lys Ala Arg Arg Ser Pro Pro Gly His His Arg His Cys Glu 
1               5                   10                  15


Gly Cys Phe Asn Arg His Cys His Ile Pro Val Glu Pro Asn Thr Ser 
            20                  25                  30


Cys Leu Val Ile Ser Cys His Leu Leu Cys Gly Ala Thr Phe His Met 
        35                  40                  45


Cys Lys Glu Ala Glu His Gln Leu Leu Cys Pro Leu Glu Gln Val Pro 
    50                  55                  60


Cys Leu Asn Ser Glu Tyr Gly Cys Pro Leu Ser Met Ser Arg His Lys 
65                  70                  75                  80


Leu Ala Lys His Leu Gln Val Cys Pro Ala Ser Val Val Cys Cys Ser 
                85                  90                  95


Met Glu Trp Asn Arg Trp Pro Asn Val Asp Ser Glu Thr Thr Leu His 
            100                 105                 110


Glu Asn Ile Met Lys Glu Thr Pro Ser Glu Glu Cys Leu Asp Thr Ala 
        115                 120                 125


Leu Ala Leu Gln Asp Gln Lys Val Leu Phe Arg Ser Leu Lys Met Val 
    130                 135                 140


Glu Leu Phe Pro Glu Thr Arg Glu Ala Thr Glu Glu Glu Pro Thr Met 
145                 150                 155                 160


Asn Gly Glu Thr Ser Val Glu Glu Met Gly Gly Ala Val Gly Gly Val 
                165                 170                 175


Asp Ile Gly Leu Val Pro His Gly Leu Ser Ala Thr Asn Gly Glu Met 
            180                 185                 190


Ala Glu Leu Ser Gln Glu Glu Arg Glu Val Leu Ala Lys Thr Lys Glu 
        195                 200                 205


Gly Met Asp Leu Val Lys Phe Gly Gln Trp Glu Asn Ile Phe Ser Lys 
    210                 215                 220


Glu His Ala Ala Ser Ala Leu Thr Asn Ser Ser Ala Ser Cys Glu Ser 
225                 230                 235                 240


Lys Asn Lys Asn Asp Ser Glu Lys Glu Gln Ile Ser Ser Gly His Asn 
                245                 250                 255


Met Val Glu Gly Glu Gly Ala Pro Lys Lys Lys Glu Pro Gln Glu Asn 
            260                 265                 270


Gln Lys Gln Gln Asp Val Arg Thr Ala Met Glu Thr Thr Gly Leu Ala 
        275                 280                 285


Pro Trp Gln Asp Gly Val Leu Glu Arg Leu Lys Thr Ala Val Asp Ala 
    290                 295                 300


Lys Asp Tyr Asn Met Tyr Leu Val His Asn Gly Arg Met Leu Ile His 
305                 310                 315                 320


Phe Gly Gln Met Pro Ala Cys Thr Pro Lys Glu Arg Asp Phe Val Tyr 
                325                 330                 335


Gly Lys Leu Glu Ala Gln Glu Val Lys Thr Val Tyr Thr Phe Lys Val 
            340                 345                 350


Pro Val Ser Tyr Cys Gly Lys Arg Ala Arg Leu Gly Asp Ala Met Leu 
        355                 360                 365


Ser Cys Lys Pro Ser Glu His Lys Ala Val Asp Thr Ser Asp Leu Gly 
    370                 375                 380


Ile Thr Val Glu Asp Leu Pro Lys Ser Asp Leu Ile Lys Thr Thr Leu 
385                 390                 395                 400


Gln Cys Ala Leu Glu Arg Glu Leu Lys Gly His Val Ile Ser Glu Ser 
                405                 410                 415


Arg Ser Ile Asp Gly Leu Phe Met Asp Phe Ala Thr Gln Thr Tyr Asn 
            420                 425                 430


Phe Glu Pro Glu Gln Phe Ser Ser Gly Thr Val Leu Ala Asp Leu Thr 
        435                 440                 445


Ala Ala Thr Pro Gly Gly Leu His Val Glu Leu His Ser Glu Cys Val 
    450                 455                 460


Thr Arg Arg His Asn Lys Ser Ser Ser Ala Phe Thr Phe Thr Cys Asn 
465                 470                 475                 480


Lys Phe Phe Arg Arg Asp Glu Phe Pro Leu His Phe Lys Asn Val His 
                485                 490                 495


Thr Asp Ile Gln Ser Cys Leu Asn Gly Trp Phe Gln His Arg Cys Pro 
            500                 505                 510


Leu Ala Tyr Leu Gly Cys Thr Phe Val Gln Asn His Phe Arg Pro Pro 
        515                 520                 525


Gly Gln Lys Ala Lys Val Ile Tyr Ser Gln Glu Leu Lys Thr Phe Ala 
    530                 535                 540


Ile Lys Pro Glu Val Ala Pro Glu Leu Ser Glu Gly Arg Lys Asn Asn 
545                 550                 555                 560


His Leu Leu Gly His Gly Gly Lys Ser Gln Asn Ser Leu Thr Ser Leu 
                565                 570                 575


Pro Leu Glu Ile Leu Lys Tyr Ile Ala Gly Phe Leu Asp Ser Val Ser 
            580                 585                 590


Leu Ala Gln Leu Ser Gln Val Ser Val Leu Met Arg Asn Ile Cys Ala 
        595                 600                 605


Thr Leu Leu Gln Glu Arg Gly Met Val Leu Leu Gln Trp Lys Lys Lys 
    610                 615                 620


Arg Tyr Ser His Gly Gly Thr Ser Trp Arg Val His Arg Glu Ile Trp 
625                 630                 635                 640


Gln Phe Ser Ser Leu Phe Ser Lys Ile Lys Ser Trp Glu Phe Asn Glu 
                645                 650                 655


Val Thr Ser Met Ser Glu His Leu Lys Ser Cys Pro Phe Asn Ile Val 
            660                 665                 670


Glu His Lys Thr Asp Pro Ile Leu Leu Thr Ser Met Cys Gln Pro Arg 
        675                 680                 685


Glu Gln Ala Arg Glu Ser Leu Val Ser Thr Phe Arg Ile Arg Pro Arg 
    690                 695                 700


Gly Arg Tyr Val Ser 
705


<210>  2270
<211>  618
<212>  DNA
<213>  Homo sapiens

<400>  2270
tctcagctgt ggctgtatat gattaccaag gagagggaag tgatgagctt tcctttgatc     60

cggacgacgt aatcactgac attgagatgg tggacgaggg ctggtggcgg ggacgttgcc    120

atggccactt tggactcttc cctgcaaatt atgtcaagct tctggagtga ctagagctca    180

ctgtctactg caactgtgat ttcccatgtc caaagtggct ctgcctccac cccctcccta    240

ttcctgctgc aaatgtctaa ccagatgagg ttctggacag acttccctct cctgcttcat    300

taagggcttg gggcagagac agcatgggga aggaggtccc cttccccaag agtcctctct    360

atcctggatg agctcatgaa catttctctt gtgttcctga ctccttccca atgaacacct    420

ctctgccacc ccaagctctg ctctcctcct ctgtgagctc tgggcttccc agtttgttta    480

cccgggaaag tacgtctaga ttgtgtggtt tgcctcattg tgctatttgc ccactttcct    540

tccctgaaga aatatctgaa ccttctttct gttcagtcct aaaattcgaa ataaagtgag    600

actatggttc acctgtat                                                  618


<210>  2271
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  2271

Met Asn Thr Ser Leu Pro Pro Gln Ala Leu Leu Ser Ser Ser Val Ser 
1               5                   10                  15


Ser Gly Leu Pro Ser Leu Phe Thr Arg Glu Ser Thr Ser Arg Leu Cys 
            20                  25                  30


Gly Leu Pro His Cys Ala Ile Cys Pro Leu Ser Phe Pro Glu Glu Ile 
        35                  40                  45


Ser Glu Pro Ser Phe Cys Ser Val Leu Lys Phe Glu Ile Lys 
    50                  55                  60


<210>  2272
<211>  2829
<212>  DNA
<213>  Homo sapiens

<400>  2272
tatactcata tgcatgaaga tagaacagag aatcatctaa gctcttcttt tggcttaaca     60

tcaaaacctt ataaatactc atgccgttta ggaaaacaga ttcatcagtt taaatattat    120

tgccatagca gcagataatc aagttaaaca actaattagg gttactattt acagaattta    180

gcatcaatct atgaagtcca gatatcttta aagactcctt tgtacaaaac aaaacaaaat    240

gttgttttaa agagaaaaaa aagtaccgta tgattacagc atcatatcgt tgacaggaga    300

gtaagattga taactcatcg atgtttttag ttccacgcct tattaggtcg gattctttga    360

actcattttt tatggtgcag aatggtgtct cctgccctgc agctgcacac agagagagga    420

cagctccttc acagttagct gagatttttt ctttgttttt accaacagtt gttaattagg    480

tggacatgca tccttaaagc taaggattgg aagctaaggc agctaagttc tagaaaatta    540

attgtttgca tcatgggggg taaaaccatg aaaaacaaaa tcaggaaagt ttaaaacata    600

ctgcaaagct aagggaagat gtagaaggca atagtgaaat atggagcatg cagtgttcta    660

gaatcaggat ggaattccct gttccatctt ggcaccactc ttgcctgcct ttgcttaatc    720

accgattctt acatcttttg ctcacaagcc acaaatggaa tcacccagtc agtgtgtcat    780

gtaaatcaag aaacaataca tgttaattag ttcttaatat gcaaaaaccc agacttgctt    840

agatacccat agttcctgag ccagatggag aacaaagctc caaaactctg cggtaatgtt    900

gggtatctgg gcaacatatc cagtcccaga gccagctagg atccagactc tcctggttgc    960

agttatccca ccaaaatcca catatttgtg tttccattat tgagtaatga aagagaagag   1020

gcacagcatt atcaactggg aatagggtaa tgtctcttca tgagcagagt gctttatact   1080

ttacaaggca cttttctagg tatcacattt cacttttgtg aggattcgtt aggaagaaaa   1140

gcgctaagtt agtgaatgaa actaagtgtc cataccagcc tgtttctaca ttaaacacct   1200

atactcagcc tgaagcccct acaaactacc tctggggctg gctgggagta aggggaggtt   1260

aggaagagga aaacctgtca gctctgactc taaccaattc tgtctcctct tctctgtagt   1320

cagcagtcgg ctttgattat aaaggagaag tggagaagca cacatctcag aaagattact   1380

ctcgtggctt tggtggccgg tacggggtgg agaaggataa atgggacaaa gcagctctgg   1440

gatatgacta caagggagag acggagaaac acgagtccca gagagattat gccaagggct   1500

ttggtggcca gtatggaatc cagaaggacc gagtggataa gagcgctgtc ggcttcaatg   1560

aaatggaggc cccgaccaca gcttataaga agacgacgcc catagaagcc gcttctagtg   1620

gtacccgtgg gctgaaggcg aaatttgagt ccatggctga ggagaagagg aagcgagagg   1680

aagaggagaa ggcacagcag gtggccagga ggcaacagga gcgaaaggct gtgacaaaga   1740

ggagccctga ggctccacag ccagtgatag ctatggaaga gccagcagta ccggccccac   1800

tgcccaagaa aatctcctca gaggcctggc ctccagttgg gactcctcca tcatcagagt   1860

ctgagcctgt gagaaccagc agggaacacc cagtgccctt gctgcccatt aggcagactc   1920

tcccggagga caatgaggag cccccagctc tgccccctag gactctggaa ggcctccagg   1980

tggaggaaga gccagtgtac gaagcagagc ctgagcctga gcccgagcct gagcccgagc   2040

ctgagaatga ctatgaggac gttgaggaga tggacaggca tgagcaggag gatgaaccag   2100

agggggacta tgaggaggtg ctcgagcctg aagattcttc tttttcttct gctctggctg   2160

gatcatcagg ctgcccggct ggggctgggg ctggggctgt ggctctgggg atctcagctg   2220

tggctgtata tgattaccaa ggagagggaa gtgatgagct ttcctttgat ccggacgacg   2280

taatcactga cattgagatg gtggacgagg gctggtggcg gggacgttgc catggccact   2340

ttggactctt ccctgcaaat tatgtcaagc ttctggagtg actagagctc actgtctact   2400

gcaactgtga tttcccatgt ccaaagtggc tctgcctcca ccccctccct attcctgctg   2460

caaatgtcta accagatgag gttctggaca gacttccctc tcctgcttca ttaagggctt   2520

ggggcagaga cagcatgggg aaggaggtcc ccttccccaa gagtcctctc tatcctggat   2580

gagctcatga acatttctct tgtgttcctg actccttccc aatgaacacc tctctgccac   2640

cccaagctct gctctcctcc tctgtgagct ctgggcttcc cagtttgttt acccgggaaa   2700

gtacgtctag attgtgtggt ttgcctcatt gtgctatttg cccactttcc ttccctgaag   2760

aaatatctga accttctttc tgttcagtcc taaaattcga aataaagtga gactatggtt   2820

cacctgtat                                                           2829


<210>  2273
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  2273

Met Glu Ala Pro Thr Thr Ala Tyr Lys Lys Thr Thr Pro Ile Glu Ala 
1               5                   10                  15


Ala Ser Ser Gly Thr Arg Gly Leu Lys Ala Lys Phe Glu Ser Met Ala 
            20                  25                  30


Glu Glu Lys Arg Lys Arg Glu Glu Glu Glu Lys Ala Gln Gln Val Ala 
        35                  40                  45


Arg Arg Gln Gln Glu Arg Lys Ala Val Thr Lys Arg Ser Pro Glu Ala 
    50                  55                  60


Pro Gln Pro Val Ile Ala Met Glu Glu Pro Ala Val Pro Ala Pro Leu 
65                  70                  75                  80


Pro Lys Lys Ile Ser Ser Glu Ala Trp Pro Pro Val Gly Thr Pro Pro 
                85                  90                  95


Ser Ser Glu Ser Glu Pro Val Arg Thr Ser Arg Glu His Pro Val Pro 
            100                 105                 110


Leu Leu Pro Ile Arg Gln Thr Leu Pro Glu Asp Asn Glu Glu Pro Pro 
        115                 120                 125


Ala Leu Pro Pro Arg Thr Leu Glu Gly Leu Gln Val Glu Glu Glu Pro 
    130                 135                 140


Val Tyr Glu Ala Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro 
145                 150                 155                 160


Glu Asn Asp Tyr Glu Asp Val Glu Glu Met Asp Arg His Glu Gln Glu 
                165                 170                 175


Asp Glu Pro Glu Gly Asp Tyr Glu Glu Val Leu Glu Pro Glu Asp Ser 
            180                 185                 190


Ser Phe Ser Ser Ala Leu Ala Gly Ser Ser Gly Cys Pro Ala Gly Ala 
        195                 200                 205


Gly Ala Gly Ala Val Ala Leu Gly Ile Ser Ala Val Ala Val Tyr Asp 
    210                 215                 220


Tyr Gln Gly Glu Gly Ser Asp Glu Leu Ser Phe Asp Pro Asp Asp Val 
225                 230                 235                 240


Ile Thr Asp Ile Glu Met Val Asp Glu Gly Trp Trp Arg Gly Arg Cys 
                245                 250                 255


His Gly His Phe Gly Leu Phe Pro Ala Asn Tyr Val Lys Leu Leu Glu 
            260                 265                 270


<210>  2274
<211>  550
<212>  DNA
<213>  Homo sapiens

<400>  2274
gcagccagag agggagtcgg tgtggacgcg aggagccggg cgcttagaac agaggcttgc     60

acaggtggag atgtggaagt ctgtagtggg ccatgatgtg tctgtttccg tggagaccca    120

gggtgatgat tgggacacag atcctgactt tgtgaatgac atctctgaaa aggagcaacg    180

atggggagcc aagaccatcg aggggtctgg acacttccct ctcctgcttc attaagggct    240

tggggcagag acagcatggg gaaggaggtc cccttcccca agagtcctct ctatcctgga    300

tgagctcatg aacatttctc ttgtgttcct gactccttcc caatgaacac ctctctgcca    360

ccccaagctc tgctctcctc ctctgtgagc tctgggcttc ccagtttgtt tacccgggaa    420

agtacgtcta gattgtgtgg tttgcctcat tgtgctattt gcccactttc cttccctgaa    480

gaaatatctg aaccttcttt ctgttcagtc ctaaaattcg aaataaagtg agactatggt    540

tcacctgtat                                                           550


<210>  2275
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  2275

Met Trp Lys Ser Val Val Gly His Asp Val Ser Val Ser Val Glu Thr 
1               5                   10                  15


Gln Gly Asp Asp Trp Asp Thr Asp Pro Asp Phe Val Asn Asp Ile Ser 
            20                  25                  30


Glu Lys Glu Gln Arg Trp Gly Ala Lys Thr Ile Glu Gly Ser Gly His 
        35                  40                  45


Phe Pro Leu Leu Leu His 
    50


<210>  2276
<211>  791
<212>  DNA
<213>  Homo sapiens

<400>  2276
gctcagtttc tcactccgaa gtggcagcag ccagagaggg agtcggtgtg gacgcgagga     60

gccgggcgct tagaacagag gcttgcacag gtggagatgt ggaagtctgt agtgggccat    120

gatgtgtctg tttccgtgga gacccagggt gatgattggg acacagatcc tgactttgtg    180

aatgacatct ctgaaaagga gcaacgatgg ggagccaaga ccatcgaggg gtctggacgc    240

acagaacaca tcaacatcca ccagctgagg aacaaagtat cagaggagca tgatgttctc    300

aggaagaaag agatggagtc agggcccaaa gcatcccatg gctatggagg tcggtttgga    360

gtagaaagag accgaatgga caagagtgca gtgggccatg agtatgttgc cgaggtggag    420

aagcactctt ctcagacgga tgctgccaaa ggctttgggg gcaagtacgg agttgagagg    480

gacagggcag acaagcatgg ggaaggaggt ccccttcccc aagagtcctc tctatcctgg    540

atgagctcat gaacatttct cttgtgttcc tgactccttc ccaatgaaca cctctctgcc    600

accccaagct ctgctctcct cctctgtgag ctctgggctt cccagtttgt ttacccggga    660

aagtacgtct agattgtgtg gtttgcctca ttgtgctatt tgcccacttt ccttccctga    720

agaaatatct gaaccttctt tctgttcagt cctaaaattc gaaataaagt gagactatgg    780

ttcacctgta t                                                         791


<210>  2277
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  2277

Met Trp Lys Ser Val Val Gly His Asp Val Ser Val Ser Val Glu Thr 
1               5                   10                  15


Gln Gly Asp Asp Trp Asp Thr Asp Pro Asp Phe Val Asn Asp Ile Ser 
            20                  25                  30


Glu Lys Glu Gln Arg Trp Gly Ala Lys Thr Ile Glu Gly Ser Gly Arg 
        35                  40                  45


Thr Glu His Ile Asn Ile His Gln Leu Arg Asn Lys Val Ser Glu Glu 
    50                  55                  60


His Asp Val Leu Arg Lys Lys Glu Met Glu Ser Gly Pro Lys Ala Ser 
65                  70                  75                  80


His Gly Tyr Gly Gly Arg Phe Gly Val Glu Arg Asp Arg Met Asp Lys 
                85                  90                  95


Ser Ala Val Gly His Glu Tyr Val Ala Glu Val Glu Lys His Ser Ser 
            100                 105                 110


Gln Thr Asp Ala Ala Lys Gly Phe Gly Gly Lys Tyr Gly Val Glu Arg 
        115                 120                 125


Asp Arg Ala Asp Lys His Gly Glu Gly Gly Pro Leu Pro Gln Glu Ser 
    130                 135                 140


Ser Leu Ser Trp Met Ser Ser 
145                 150


<210>  2278
<211>  2037
<212>  DNA
<213>  Homo sapiens

<400>  2278
gacgaaaacc tgaatacgga actgaagcag cagctcagtt tctcactccg aagtggcagc     60

agccagagag ggagtcggtg tggacgcgag gagccgggcg cttagaacag aggcttgcac    120

aggtggagat gtggaagtct gtagtgggcc atgatgtgtc tgtttccgtg gagacccagg    180

gtgatgattg ggacacagat cctgactttg tgaatgacat ctctgaaaag gagcaacgat    240

ggggagccaa gaccatcgag gggtctggac gcacagaaca catcaacatc caccagctga    300

ggaacaaagt atcagaggag catgatgttc tcaggaagaa agagatggag tcagggccca    360

aagcatccca tggctatgga ggtcggtttg gagtagaaag agaccgaatg gacaagagtg    420

cagtgggcca tgagtatgtt gccgaggtgg agaagcactc ttctcagacg gatgctgcca    480

aaggctttgg gggcaagtac ggagttgaga gggacagggc agacaagtca gcagtcggct    540

ttgattataa aggagaagtg gagaagcaca catctcagaa agattactct cgtggctttg    600

gtggccggta cggggtggag aaggataaat gggacaaagc agctctggga tatgactaca    660

agggagagac ggagaaacac gagtcccaga gagattatgc caagggcttt ggtggccagt    720

atggaatcca gaaggaccga gtggataaga gcgctgtcgg cttcaatgaa atggaggccc    780

cgaccacagc ttataagaag acgacgccca tagaagccgc ttctagtggt acccgtgggc    840

tgaaggcgaa atttgagtcc atggctgagg agaagaggaa gcgagaggaa gaggagaagg    900

cacagcaggt ggccaggagg caacaggagc gaaaggctgt gacaaagagg agccctgagg    960

ctccacagcc agtgatagct atggaagagc cagcagtacc ggccccactg cccaagaaaa   1020

tctcctcaga ggcctggcct ccagttggga ctcctccatc atcagagtct gagcctgtga   1080

gaaccagcag ggaacaccca gtgcccttgc tgcccattag gcagactctc ccggaggaca   1140

atgaggagcc cccagctctg ccccctagga ctctggaagg cctccaggtg gaggaagagc   1200

cagtgtacga agcagagcct gagcctgagc ccgagcctga gcccgagcct gagaatgact   1260

atgaggacgt tgaggagatg gacaggcatg agcaggagga tgaaccagag ggggactatg   1320

aggaggtgct cgagcctgaa gattcttctt tttcttctgc tctggctgga tcatcaggct   1380

gcccggctgg ggctggggct ggggctgtgg ctctggggat ctcagctgtg gctgtatatg   1440

attaccaagg agagggaagt gatgagcttt cctttgatcc ggacgacgta atcactgaca   1500

ttgagatggt ggacgagggc tggtggcggg gacgttgcca tggccacttt ggactcttcc   1560

ctgcaaatta tgtcaagctt ctggagtgac tagagctcac tgtctactgc aactgtgatt   1620

tcccatgtcc aaagtggctc tgcctccacc ccctccctat tcctgctgca aatgtctaac   1680

cagatgaggt tctggacaga cttccctctc ctgcttcatt aagggcttgg ggcagagaca   1740

gcatggggaa ggaggtcccc ttccccaaga gtcctctcta tcctggatga gctcatgaac   1800

atttctcttg tgttcctgac tccttcccaa tgaacacctc tctgccaccc caagctctgc   1860

tctcctcctc tgtgagctct gggcttccca gtttgtttac ccgggaaagt acgtctagat   1920

tgtgtggttt gcctcattgt gctatttgcc cactttcctt ccctgaagaa atatctgaac   1980

cttctttctg ttcagtccta aaattcgaaa taaagtgaga ctatggttca cctgtat      2037


<210>  2279
<211>  486
<212>  PRT
<213>  Homo sapiens

<400>  2279

Met Trp Lys Ser Val Val Gly His Asp Val Ser Val Ser Val Glu Thr 
1               5                   10                  15


Gln Gly Asp Asp Trp Asp Thr Asp Pro Asp Phe Val Asn Asp Ile Ser 
            20                  25                  30


Glu Lys Glu Gln Arg Trp Gly Ala Lys Thr Ile Glu Gly Ser Gly Arg 
        35                  40                  45


Thr Glu His Ile Asn Ile His Gln Leu Arg Asn Lys Val Ser Glu Glu 
    50                  55                  60


His Asp Val Leu Arg Lys Lys Glu Met Glu Ser Gly Pro Lys Ala Ser 
65                  70                  75                  80


His Gly Tyr Gly Gly Arg Phe Gly Val Glu Arg Asp Arg Met Asp Lys 
                85                  90                  95


Ser Ala Val Gly His Glu Tyr Val Ala Glu Val Glu Lys His Ser Ser 
            100                 105                 110


Gln Thr Asp Ala Ala Lys Gly Phe Gly Gly Lys Tyr Gly Val Glu Arg 
        115                 120                 125


Asp Arg Ala Asp Lys Ser Ala Val Gly Phe Asp Tyr Lys Gly Glu Val 
    130                 135                 140


Glu Lys His Thr Ser Gln Lys Asp Tyr Ser Arg Gly Phe Gly Gly Arg 
145                 150                 155                 160


Tyr Gly Val Glu Lys Asp Lys Trp Asp Lys Ala Ala Leu Gly Tyr Asp 
                165                 170                 175


Tyr Lys Gly Glu Thr Glu Lys His Glu Ser Gln Arg Asp Tyr Ala Lys 
            180                 185                 190


Gly Phe Gly Gly Gln Tyr Gly Ile Gln Lys Asp Arg Val Asp Lys Ser 
        195                 200                 205


Ala Val Gly Phe Asn Glu Met Glu Ala Pro Thr Thr Ala Tyr Lys Lys 
    210                 215                 220


Thr Thr Pro Ile Glu Ala Ala Ser Ser Gly Thr Arg Gly Leu Lys Ala 
225                 230                 235                 240


Lys Phe Glu Ser Met Ala Glu Glu Lys Arg Lys Arg Glu Glu Glu Glu 
                245                 250                 255


Lys Ala Gln Gln Val Ala Arg Arg Gln Gln Glu Arg Lys Ala Val Thr 
            260                 265                 270


Lys Arg Ser Pro Glu Ala Pro Gln Pro Val Ile Ala Met Glu Glu Pro 
        275                 280                 285


Ala Val Pro Ala Pro Leu Pro Lys Lys Ile Ser Ser Glu Ala Trp Pro 
    290                 295                 300


Pro Val Gly Thr Pro Pro Ser Ser Glu Ser Glu Pro Val Arg Thr Ser 
305                 310                 315                 320


Arg Glu His Pro Val Pro Leu Leu Pro Ile Arg Gln Thr Leu Pro Glu 
                325                 330                 335


Asp Asn Glu Glu Pro Pro Ala Leu Pro Pro Arg Thr Leu Glu Gly Leu 
            340                 345                 350


Gln Val Glu Glu Glu Pro Val Tyr Glu Ala Glu Pro Glu Pro Glu Pro 
        355                 360                 365


Glu Pro Glu Pro Glu Pro Glu Asn Asp Tyr Glu Asp Val Glu Glu Met 
    370                 375                 380


Asp Arg His Glu Gln Glu Asp Glu Pro Glu Gly Asp Tyr Glu Glu Val 
385                 390                 395                 400


Leu Glu Pro Glu Asp Ser Ser Phe Ser Ser Ala Leu Ala Gly Ser Ser 
                405                 410                 415


Gly Cys Pro Ala Gly Ala Gly Ala Gly Ala Val Ala Leu Gly Ile Ser 
            420                 425                 430


Ala Val Ala Val Tyr Asp Tyr Gln Gly Glu Gly Ser Asp Glu Leu Ser 
        435                 440                 445


Phe Asp Pro Asp Asp Val Ile Thr Asp Ile Glu Met Val Asp Glu Gly 
    450                 455                 460


Trp Trp Arg Gly Arg Cys His Gly His Phe Gly Leu Phe Pro Ala Asn 
465                 470                 475                 480


Tyr Val Lys Leu Leu Glu 
                485


<210>  2280
<211>  666
<212>  DNA
<213>  Homo sapiens

<400>  2280
cagctgtggc tgtatatgat taccaaggag gtaggttggg agtggcccga ggagcctggt     60

acatggaggc ccctgatata agacaggggg acatgtgaaa agagattcat gtctgaccat    120

tctaatatcc cctcaacttt ctccccagag ggaagtgatg agctttcctt tgatccggac    180

gacgtaatca ctgacattga gatggtggac gagggctggt ggcggggacg ttgccatggc    240

cactttggac tcttccctgc aaattatgtc aagcttctgg agtgactaga gctcactgtc    300

tactgcaact gtgatttccc atgtccaaag tggctctgcc tccaccccct ccctattcct    360

gctgcaaatg tctaaccaga tgaggtcccc ttccccaaga gtcctctcta tcctggatga    420

gctcatgaac atttctcttg tgttcctgac tccttcccaa tgaacacctc tctgccaccc    480

caagctctgc tctcctcctc tgtgagctct gggcttccca gtttgtttac ccgggaaagt    540

acgtctagat tgtgtggttt gcctcattgt gctatttgcc cactttcctt ccctgaagaa    600

atatctgaac cttctttctg ttcagtccta aaattcgaaa taaagtgaga ctatggttca    660

cctgta                                                               666


<210>  2281
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  2281

Met Ser Asn Gln Met Arg Ser Pro Ser Pro Arg Val Leu Ser Ile Leu 
1               5                   10                  15


Asp Glu Leu Met Asn Ile Ser Leu Val Phe Leu Thr Pro Ser Gln 
            20                  25                  30


<210>  2282
<211>  323
<212>  DNA
<213>  Homo sapiens

<400>  2282
agccagagag ggagtcggtg tggacgcgag gagccgggcg cttagaacag aggcttgcac     60

aggtggagat gtggaagtct gtagtgggcc atgatgttgt tcctgactcc ttcccaatga    120

acacctctct gccaccccaa gctctgctct cctcctctgt gagctctggg cttcccagtt    180

tgtttacccg ggaaagtacg tctagattgt gtggtttgcc tcattgtgct atttgcccac    240

tttccttccc tgaagaaata tctgaacctt ctttctgttc agtcctaaaa ttcgaaataa    300

agtgagacta tggttcacct gta                                            323


<210>  2283
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  2283

Met Trp Lys Ser Val Val Gly His Asp Val Val Pro Asp Ser Phe Pro 
1               5                   10                  15


Met Asn Thr Ser Leu Pro Pro Gln Ala Leu Leu Ser Ser Ser Val Ser 
            20                  25                  30


Ser Gly Leu Pro Ser Leu Phe Thr Arg Glu Ser Thr Ser Arg Leu Cys 
        35                  40                  45


Gly Leu Pro His Cys Ala Ile Cys Pro Leu Ser Phe Pro Glu Glu Ile 
    50                  55                  60


Ser Glu Pro Ser Phe Cys Ser Val Leu Lys Phe Glu Ile Lys 
65                  70                  75


<210>  2284
<211>  623
<212>  DNA
<213>  Homo sapiens

<400>  2284
gacgaaaacc tgaatacgga actgaagcag cagctcagtt tctcactccg aagtggcagc     60

agccagagag ggagtcggtg tggacgcgag gagccgggcg cttagaacag aggcttgcac    120

aggtggagat gtggaagtct gtagtgggcc atgatgtgtc tgtttccgtg gagacccagg    180

gtgatgattg ggacacagat cctgactttg tgaatgacat ctctgaaaag gagcaacgat    240

ggggagccaa gaccatcgag gggtctggac gcacagaaca catcaacatc caccagctga    300

ggaacaaagt atcagaggag catgatgttc tcaggaagaa agagatggag tcagggccca    360

aagcatccca tggctatgga ggtcggtttg gagtagaaag agaccgaatg gacaagagtg    420

cagtgggcca tgagtatgtt gccgaggtgg agaagcactc ttctcagacg gatgctgcca    480

aaggctttgg gggcaagtac ggagttgaga gggacagggc agacaagtca gcagtcggct    540

ttgattataa aggagaagtg gagaagcaca catctcagaa agattatgcc aagggctttg    600

gtggccagta tggaatccag aag                                            623


<210>  2285
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  2285

Met Trp Lys Ser Val Val Gly His Asp Val Ser Val Ser Val Glu Thr 
1               5                   10                  15


Gln Gly Asp Asp Trp Asp Thr Asp Pro Asp Phe Val Asn Asp Ile Ser 
            20                  25                  30


Glu Lys Glu Gln Arg Trp Gly Ala Lys Thr Ile Glu Gly Ser Gly Arg 
        35                  40                  45


Thr Glu His Ile Asn Ile His Gln Leu Arg Asn Lys Val Ser Glu Glu 
    50                  55                  60


His Asp Val Leu Arg Lys Lys Glu Met Glu Ser Gly Pro Lys Ala Ser 
65                  70                  75                  80


His Gly Tyr Gly Gly Arg Phe Gly Val Glu Arg Asp Arg Met Asp Lys 
                85                  90                  95


Ser Ala Val Gly His Glu Tyr Val Ala Glu Val Glu Lys His Ser Ser 
            100                 105                 110


Gln Thr Asp Ala Ala Lys Gly Phe Gly Gly Lys Tyr Gly Val Glu Arg 
        115                 120                 125


Asp Arg Ala Asp Lys Ser Ala Val Gly Phe Asp Tyr Lys Gly Glu Val 
    130                 135                 140


Glu Lys His Thr Ser Gln Lys Asp Tyr Ala Lys Gly Phe Gly Gly Gln 
145                 150                 155                 160


Tyr Gly Ile Gln 



<210>  2286
<211>  1429
<212>  DNA
<213>  Homo sapiens

<400>  2286
gtatcagagg agcatgatgt tctcaggaag aaagagatgg agtcagggcc caaagcatcc     60

catggctatg gaggtcggtt tggagtagaa agagaccgaa tggacaagag tgcagtgggc    120

catgagtatg ttgccgaggt ggagaagcac tcttctcaga cggatgctgc caaaggcttt    180

gggggcaagt acggagttga gagggacagg gcagacaagg taagtgacca ctctctctcc    240

caaccaccca cctccagtcc tgtgaaaatt gcccacgatc acccctggat ggaggcacat    300

gcttctttgt tgaaagacag gacagtggat gctgtgagga cctgacaccg tcacagggat    360

acctccctca gcaagttcct tggtgccaat gttggaagcc acatgctgag ctgaaagaca    420

gtgattcaaa taggagaaga ctctcaaact gtgtgtttga atgaataatt cctcaagcca    480

ctggttttta ttatactcat atgcatgaag atagaacaga gaatcatcta agctcttctt    540

ttggcttaac atcaaaacct tataaatact catgccgttt aggaaaacag attcatcagt    600

ttaaatatta ttgccatagc agcagataat caagttaaac aactaattag ggttactatt    660

tacagaattt agcatcaatc tatgaagtcc agatatcttt aaagactcct ttgtacaaaa    720

caaaacaaaa tgttgtttta aagagaaaaa aaagtaccgt atgattacag catcatatcg    780

ttgacaggag agtaagattg ataactcatc gatgttttta gttccacgcc ttattaggtc    840

ggattctttg aactcatttt ttatggtgca gaatggtgtc tcctgccctg cagctgcaca    900

cagagagagg acagctcctt cacagttagc tgagattttt tctttgtttt taccaacagt    960

tgttaattag gtggacatgc atccttaaag ctaaggattg gaagctaagg cagctaagtt   1020

ctagaaaatt aattgtttgc atcatggggg gtaaaaccat gaaaaacaaa atcaggaaag   1080

tttaaaacat actgcaaagc taagggaaga tgtagaaggc aatagtgaaa tatggagcat   1140

gcagtgttct agaatcagga tggaattccc tgttccatct tggcaccact cttgcctgcc   1200

tttgcttaat caccgattct tacatctttt gctcacaagc cacaaatgga atcacccagt   1260

cagtgtgtca tgtaaatcaa gaaacaatac atgttaatta gttcttaata tgcaaaaacc   1320

cagacttgct tagataccca tagttcctga gccagatgga gaacaaagct ccaaaactct   1380

gcggtaatgt tgggtatctg ggcaacatat ccagtcccag agccagcta               1429


<210>  2287
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  2287

Met Glu Ser Gly Pro Lys Ala Ser His Gly Tyr Gly Gly Arg Phe Gly 
1               5                   10                  15


Val Glu Arg Asp Arg Met Asp Lys Ser Ala Val Gly His Glu Tyr Val 
            20                  25                  30


Ala Glu Val Glu Lys His Ser Ser Gln Thr Asp Ala Ala Lys Gly Phe 
        35                  40                  45


Gly Gly Lys Tyr Gly Val Glu Arg Asp Arg Ala Asp Lys Val Ser Asp 
    50                  55                  60


His Ser Leu Ser Gln Pro Pro Thr Ser Ser Pro Val Lys Ile Ala His 
65                  70                  75                  80


Asp His Pro Trp Met Glu Ala His Ala Ser Leu Leu Lys Asp Arg Thr 
                85                  90                  95


Val Asp Ala Val Arg Thr 
            100


<210>  2288
<211>  1705
<212>  DNA
<213>  Homo sapiens

<400>  2288
gctcagtttc tcactccgaa gtggcagcag ccagagaggg agtcggtgtg gacgcgagga     60

gccgggcgct tagaacagag gcttgcacag gtggagatgt ggaagtctgt agtgggccat    120

gatgtgtctg tttccgtgga gacccagggt gatgattggg acacagatcc tgactttgtg    180

aatgacatct ctgaaaagga gcaacgatgg ggagccaaga ccatcgaggg gtctggacgc    240

acagaacaca tcaacatcca ccagctgagg aacaaagtat cagaggagca tgatgttctc    300

aggaagaaag agatggagtc agggcccaaa gcatcccatg gctatggagg tcggtttgga    360

gtagaaagag accgaatgga caagagtgca gtgggccatg agtatgttgc cgaggtggag    420

aagcactctt ctcagacgga tgctgccaaa ggctttgggg gcaagtacgg agttgagagg    480

gacagggcag acaaggtaag tgaccactct ctctcccaac cacccacctc cagtcctgtg    540

aaaattgccc acgatcaccc ctggatggag gcacatgctt ctttgttgaa agacaggaca    600

gtggatgctg tgaggacctg acaccgtcac agggatacct ccctcagcaa gttccttggt    660

gccaatgttg gaagccacat gctgagctga aagacagtga ttcaaatagg agaagactct    720

caaactgtgt gtttgaatga ataattcctc aagccactgg tttttattat actcatatgc    780

atgaagatag aacagagaat catctaagct cttcttttgg cttaacatca aaaccttata    840

aatactcatg ccgtttagga aaacagattc atcagtttaa atattattgc catagcagca    900

gataatcaag ttaaacaact aattagggtt actatttaca gaatttagca tcaatctatg    960

aagtccagat atctttaaag actcctttgt acaaaacaaa acaaaatgtt gttttaaaga   1020

gaaaaaaaag taccgtatga ttacagcatc atatcgttga caggagagta agattgataa   1080

ctcatcgatg tttttagttc cacgccttat taggtcggat tctttgaact cattttttat   1140

ggtgcagaat ggtgtctcct gccctgcagc tgcacacaga gagaggacag ctccttcaca   1200

gttagctgag attttttctt tgtttttacc aacagttgtt aattaggtgg acatgcatcc   1260

ttaaagctaa ggattggaag ctaaggcagc taagttctag aaaattaatt gtttgcatca   1320

tggggggtaa aaccatgaaa aacaaaatca ggaaagttta aaacatactg caaagctaag   1380

ggaagatgta gaaggcaata gtgaaatatg gagcatgcag tgttctagaa tcaggatgga   1440

attccctgtt ccatcttggc accactcttg cctgcctttg cttaatcacc gattcttaca   1500

tcttttgctc acaagccaca aatggaatca cccagtcagt gtgtcatgta aatcaagaaa   1560

caatacatgt taattagttc ttaatatgca aaaacccaga cttgcttaga tacccatagt   1620

tcctgagcca gatggagaac aaagctccaa aactctgcgg taatgttggg tatctgggca   1680

acatatccag tcccagagcc agcta                                         1705


<210>  2289
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  2289

Met Trp Lys Ser Val Val Gly His Asp Val Ser Val Ser Val Glu Thr 
1               5                   10                  15


Gln Gly Asp Asp Trp Asp Thr Asp Pro Asp Phe Val Asn Asp Ile Ser 
            20                  25                  30


Glu Lys Glu Gln Arg Trp Gly Ala Lys Thr Ile Glu Gly Ser Gly Arg 
        35                  40                  45


Thr Glu His Ile Asn Ile His Gln Leu Arg Asn Lys Val Ser Glu Glu 
    50                  55                  60


His Asp Val Leu Arg Lys Lys Glu Met Glu Ser Gly Pro Lys Ala Ser 
65                  70                  75                  80


His Gly Tyr Gly Gly Arg Phe Gly Val Glu Arg Asp Arg Met Asp Lys 
                85                  90                  95


Ser Ala Val Gly His Glu Tyr Val Ala Glu Val Glu Lys His Ser Ser 
            100                 105                 110


Gln Thr Asp Ala Ala Lys Gly Phe Gly Gly Lys Tyr Gly Val Glu Arg 
        115                 120                 125


Asp Arg Ala Asp Lys Val Ser Asp His Ser Leu Ser Gln Pro Pro Thr 
    130                 135                 140


Ser Ser Pro Val Lys Ile Ala His Asp His Pro Trp Met Glu Ala His 
145                 150                 155                 160


Ala Ser Leu Leu Lys Asp Arg Thr Val Asp Ala Val Arg Thr 
                165                 170


<210>  2290
<211>  595
<212>  DNA
<213>  Homo sapiens

<400>  2290
gcagctcagt ttctcactcc gaagtggcag cagccagaga gggagtcggt gtggacgcga     60

ggagccgggc gcttagaaca gaggcttgca caggtggaga tgtggaagtc tgtagtgggc    120

catgatgtgt ctgtttccgt ggagacccag ggtgatgatt gggacacaga tcctgacttt    180

gtgaatgaca tctctgaaaa ggagcaacga tggggagcca agaccatcga ggggtctgga    240

cgcacagaac acatcaacat ccaccagctg aggaacaaag tatcagagga gcatgatgtt    300

ctcaggaaga aagagatgga gtcagggccc aaagcatccc atggctatgg aggtcggttt    360

ggagtagaaa gagaccgaat ggacaagagt gcagtgggcc atgagtatgt tgccgaggtg    420

gagaagcact cttctcagac ggatgctgcc aaaggctttg ggggcaagta cggagttgag    480

agggacaggg cagacaagac aggacagtgg atgctgtgag gacctgacac cgtcacaggg    540

atacctccct cagcaagttc cttggtgcca atgttggaag ccacatgctg agctg         595


<210>  2291
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  2291

Met Trp Lys Ser Val Val Gly His Asp Val Ser Val Ser Val Glu Thr 
1               5                   10                  15


Gln Gly Asp Asp Trp Asp Thr Asp Pro Asp Phe Val Asn Asp Ile Ser 
            20                  25                  30


Glu Lys Glu Gln Arg Trp Gly Ala Lys Thr Ile Glu Gly Ser Gly Arg 
        35                  40                  45


Thr Glu His Ile Asn Ile His Gln Leu Arg Asn Lys Val Ser Glu Glu 
    50                  55                  60


His Asp Val Leu Arg Lys Lys Glu Met Glu Ser Gly Pro Lys Ala Ser 
65                  70                  75                  80


His Gly Tyr Gly Gly Arg Phe Gly Val Glu Arg Asp Arg Met Asp Lys 
                85                  90                  95


Ser Ala Val Gly His Glu Tyr Val Ala Glu Val Glu Lys His Ser Ser 
            100                 105                 110


Gln Thr Asp Ala Ala Lys Gly Phe Gly Gly Lys Tyr Gly Val Glu Arg 
        115                 120                 125


Asp Arg Ala Asp Lys Thr Gly Gln Trp Met Leu 
    130                 135


<210>  2292
<211>  584
<212>  DNA
<213>  Homo sapiens

<400>  2292
agctcagttt ctcactccga agtggcagca gccagagagg gagtcggtgt ggacgcgagg     60

agccgggcgc ttagaacaga ggcttgcaca ggtggagatg tggaagtctg tagtgggcca    120

tgatgtgtct gtttccgtgg agacccaggg tgatgattgg gacacagatc ctgactttgt    180

gaatgacatc tctgaaaagg agcaacgatg gggagccaag accatcgagg ggtctggacg    240

cacagaacac atcaaaaaca gttcagcttg tggaccacac actgagtggc actgctctgg    300

aataatcttt cagcacttcc tggaaccagt ctggccttta gattaaatct ttactgagct    360

ataaccatag gatgtctgcc tcagtggccc tgtcctcttc tcgtgccctg acattttata    420

gcaagtggaa ataaagaatg gtgtaatgcc aagagtatag aaatagaatt ctggagctct    480

agggactgat tccagctctg ctgtaaaaag gcttatgatg ctgaggagag taataatatt    540

ttaccatcct atcttgattt ccagcgctga ctggagatta tagt                     584


<210>  2293
<211>  82
<212>  PRT
<213>  Homo sapiens

<400>  2293

Met Trp Lys Ser Val Val Gly His Asp Val Ser Val Ser Val Glu Thr 
1               5                   10                  15


Gln Gly Asp Asp Trp Asp Thr Asp Pro Asp Phe Val Asn Asp Ile Ser 
            20                  25                  30


Glu Lys Glu Gln Arg Trp Gly Ala Lys Thr Ile Glu Gly Ser Gly Arg 
        35                  40                  45


Thr Glu His Ile Lys Asn Ser Ser Ala Cys Gly Pro His Thr Glu Trp 
    50                  55                  60


His Cys Ser Gly Ile Ile Phe Gln His Phe Leu Glu Pro Val Trp Pro 
65                  70                  75                  80


Leu Asp 



<210>  2294
<211>  502
<212>  DNA
<213>  Homo sapiens

<400>  2294
gggagtcggt gtggacgcga ggagccgggc gcttagaaca gaggcttgca caggtggaga     60

tgtggaagtc tgtagtgggc catgatgtgt ctgtttccgt ggagacccag ggtgatgatt    120

gggacacaga tcctgacttt gtgaatgaca tctctgaaaa ggagcaacga tggggagcca    180

agaccatcga ggggtctgga cgcacagaac acatcaagta ggtgccgaaa ggactggaga    240

aaaggaaggg ggttatggga agagcccaaa gaaaactcgg agacttgggg gaagatttta    300

aaaagtgtca gtggatgacc acattgcaca agcaacatac tgtgaaagcc tggcacaagt    360

ttctacaact ggatgacaat accacattgt ttaatcagaa ataaatggtt tcggccgggc    420

gtggtggctc acgcttgtaa tcccaaaact ttggaaggcc gagcgaggaa gatcacttga    480

ggtcaggagt tcaagaccag ca                                             502


<210>  2295
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  2295

Met Thr Ser Leu Lys Arg Ser Asn Asp Gly Glu Pro Arg Pro Ser Arg 
1               5                   10                  15


Gly Leu Asp Ala Gln Asn Thr Ser Ser Arg Cys Arg Lys Asp Trp Arg 
            20                  25                  30


Lys Gly Arg Gly Leu Trp Glu Glu Pro Lys Glu Asn Ser Glu Thr Trp 
        35                  40                  45


Gly Lys Ile Leu Lys Ser Val Ser Gly 
    50                  55


<210>  2296
<211>  890
<212>  DNA
<213>  Homo sapiens

<400>  2296
agcagctcag tttctcactc cgaagtggca gcagccagag agggagtcgg tgtggacgcg     60

aggagccggg cgcttagaac agaggcttgc acaggtggag atgtggaagt ctgtagtggg    120

ccatgatgtg tctgtttccg tggagaccca gggtgatgat tgggacacag atcctgactt    180

tgtgaatgac atctctgaaa aggagcaacg atggggagcc aagaccatcg aggggtctgg    240

acgcacagaa cacatcaagt aggtgccgaa aggactggag aaaaggaagg gggttatggg    300

aagagcccaa agaaaactcg gagacttggg ggaaggtgag ggaggaaaag gatagggtag    360

ttcatgtcta tgtattattg tgtttgtttt ttttctagag tctgttcctg tgtgtacctg    420

tgtgtcattg catatttcca ttttatgtct ctcctcttac cctcctcaac cctattatct    480

atcttttata cctaacaact ctgctatttc cccaagtggg tctattggat taactgcctc    540

ccttccttta gtaaggcatg agagattcat agaggaagtg gaccaaatac taaggtcctc    600

tctatctatc tacctggcaa tcatctatct cctatctatc tcttcagata aatgtaaata    660

tgtatttaga attcagggtg acttccttca gatgaactaa gaacaattca gtaaaatgtc    720

aaggtgaaga actcagaata aatgctataa aaagaggcca cttcagctcc cataactggc    780

ccaaataact tttaaaatac agatttgtac ttagctattt gacagaagtt ggaagccatg    840

aatggtaata tgaagaaatg taacacttgg aaaacctgtt gataaaaact               890


<210>  2297
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  2297

Met Trp Lys Ser Val Val Gly His Asp Val Ser Val Ser Val Glu Thr 
1               5                   10                  15


Gln Gly Asp Asp Trp Asp Thr Asp Pro Asp Phe Val Asn Asp Ile Ser 
            20                  25                  30


Glu Lys Glu Gln Arg Trp Gly Ala Lys Thr Ile Glu Gly Ser Gly Arg 
        35                  40                  45


Thr Glu His Ile Lys 
    50


<210>  2298
<211>  450
<212>  DNA
<213>  Homo sapiens

<400>  2298
actccgaagt ggcagcagcc agagagggag tcggtgtgga cgcgaggagc cgggcgctta     60

gaacagaggc ttgcacaggt ggagatgtgg aagtctgtag tgggccatga tgtgtctgtt    120

tccgtggaga cccagggtga tgattgggac acagatcctg actttgtggt gagtttggaa    180

gtagctttgc ttggacagtg cagagggtgg ggtgaggagg gcatctgggc cactctgtga    240

tctttgagga tgcttggaaa agggccttct aggactgaga cagccctcat actgggacta    300

attggtagga caattggctg tcacctgtgg ggcatgcacg atacctggta tcagggatga    360

aaagagacag gtgtgggtga gtttgacagt gtgattgaca ggccatggca ggctacactg    420

aaggtgagaa gcaggtgaac ctgggtctcc                                     450


<210>  2299
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  2299

Met Trp Lys Ser Val Val Gly His Asp Val Ser Val Ser Val Glu Thr 
1               5                   10                  15


Gln Gly Asp Asp Trp Asp Thr Asp Pro Asp Phe Val Val Ser Leu Glu 
            20                  25                  30


Val Ala Leu Leu Gly Gln Cys Arg Gly Trp Gly Glu Glu Gly Ile Trp 
        35                  40                  45


Ala Thr Leu 
    50


<210>  2300
<211>  569
<212>  DNA
<213>  Homo sapiens

<400>  2300
aacatatgat ctgtgctgct gttggtgcag gaggacagga gggaaataag ctggaagcca     60

tggatgtgga gagtctggct tcaagatgga gcttgtttac ctgcagggcc ccatgcagaa    120

cctcatgaga cgtgacttca gaggcctcct ctctgaaggt gagggaggcg tcagctgttc    180

agagagagag gctgccttgc ctggggacac acagctagcc agtggccgga gcagcagtgg    240

atgcagttgt cctgatgcat agttcaagaa gctttttttt tttttttttt tttcacgtgt    300

gaaaacatct attgggaaaa tggaaaaatc atttgacctc atattcctca tagctgacat    360

gcctggctcc tttctgtgga gaagatcctg agaggaacca caacttgaca aaaccaaaat    420

gtggtggtga gccaacttca attttgcaga aactgacttg gaaagaactg attacctgaa    480

ggaccgtgag gatcaaagtt gtcccactga ccaggctgta aactttggaa ctgataagtg    540

agagagataa ggtaaacttc tttaccttt                                      569


<210>  2301
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  2301

Met Glu Leu Val Tyr Leu Gln Gly Pro Met Gln Asn Leu Met Arg Arg 
1               5                   10                  15


Asp Phe Arg Gly Leu Leu Ser Glu Gly Glu Gly Gly Val Ser Cys Ser 
            20                  25                  30


Glu Arg Glu Ala Ala Leu Pro Gly Asp Thr Gln Leu Ala Ser Gly Arg 
        35                  40                  45


Ser Ser Ser Gly Cys Ser Cys Pro Asp Ala 
    50                  55


<210>  2302
<211>  4673
<212>  DNA
<213>  Homo sapiens

<400>  2302
gtcagtctgg ccggctccgt cctcccgtag gctccgctgt agctagcaat gtgacaccag     60

gacgcactcg ctctcgcgcg ctctcccagg ctcgttctcc ctcgccctct ctctctcaca    120

cacgcacgca cacacccacc tctcccataa acacacacac acacatgcac acccacaccc    180

acgcgcgccc gcaccgcccc acgcgcacac actcctgccc acgcccacgc agcgctccgg    240

gaagtccggt ccgggcgaga gcgcgaaagg ataccgagaa gccacccgcg gagagcgcag    300

cggcgccctg ggacgcggcg ctctcccggc gctgctgcct cggcttggtc tcggcctgcg    360

ggccgtcggc cggcgatggc cctggattat ctactactgc tcctcctggc atccgcagtg    420

gctgcgatgg aagaaacgtt aatggacacc agaacggcta ctgcagagct gggctggacg    480

gccaatcctg cgtccgggtg ggaagaagtc agtggctacg atgaaaacct gaacaccatc    540

cgcacctacc aggtgtgcaa tgtcttcgag cccaaccaga acaattggct gctcaccacc    600

ttcatcaacc ggcggggggc ccatcgcatc tacacagaga tgcgcttcac tgtgagagac    660

tgcagcagcc tccctaatgt cccaggatcc tgcaaggaga ccttcaactt gtattactat    720

gagactgact ctgtcattgc caccaagaag tcagccttct ggtctgaggc cccctacctc    780

aaagtagaca ccattgctgc agatgagagc ttctcccagg tggactttgg gggaaggctg    840

atgaaggtaa acacagaagt caggagcttt gggcctctta ctcggaatgg tttttacctc    900

gcttttcagg attatggagc ctgtatgtct cttctttctg tccgtgtctt cttcaaaaag    960

tgtcccagca ttgtgcaaaa ttttgcagtg tttccagaga ctatgacagg ggcagagagc   1020

acatctctgg tgattgctcg gggcacatgc atccccaacg cagaggaagt ggacgtgccc   1080

atcaaactct actgcaacgg ggatggggaa tggatggtgc ctattgggcg atgcacctgc   1140

aagcctggct atgagcctga gaacagcgtg gcatgcaagg cttgccctgc agggacattc   1200

aaggccagcc aggaagctga aggctgctcc cactgcccct ccaacagccg ctcccctgca   1260

gaggcgtctc ccatctgcac ctgtcggacc ggttattacc gagcggactt tgaccctcca   1320

gaagtggcat gcactagcgt cccatcaggt ccccgcaatg ttatctccat cgtcaatgag   1380

acgtccatca ttctggagtg gcaccctcca agggagacag gtgggcggga tgatgtgacc   1440

tacaacatca tctgcaaaaa gtgccgggca gaccgccgga gctgctcccg ctgtgacgac   1500

aatgtggagt ttgtgcccag gcagctgggc ctgacggagt gccgcgtctc catcagcagc   1560

ctgtgggccc acacccccta cacctttgac atccaggcca tcaatggagt ctccagcaag   1620

agtcccttcc ccccacagca cgtctctgtc aacatcacca caaaccaagc cgccccctcc   1680

accgttccca tcatgcacca agtcagtgcc actatgagga gcatcacctt gtcatggcca   1740

cagccggagc agcccaatgg catcatcctg gactatgaga tccggtacta tgagaaggaa   1800

cacaatgagt tcaactcctc catggccagg agtcagacca acacagcaag gattgatggg   1860

ctgcggcctg gcatggtata tgtggtacag gtgcgtgccc gcactgttgc tggctacggc   1920

aagttcagtg gcaagatgtg cttccagact ctgactgacg atgattacaa gtcagagctg   1980

agggagcagc tgcccctgat tgctggctcg gcagcggccg gggtcgtgtt cgttgtgtcc   2040

ttggtggcca tctctatcgt ctgtagcagg aaacgggctt atagcaaaga ggctgtgtac   2100

agcgataagc tccagcatta cagcacaggc cgaggctccc cagggatgaa gatctacatt   2160

gaccccttca cttacgagga tcccaacgaa gctgtccggg agtttgccaa ggagattgat   2220

gtatcttttg tgaaaattga agaggtcatc ggagcagggg agtttggaga agtgtacaag   2280

gggcgtttga aactgccagg caagagggaa atctacgtgg ccatcaagac cctgaaggca   2340

gggtactcgg agaagcagcg tcgggacttt ctgagtgagg cgagcatcat gggccagttc   2400

gaccatccta acatcattcg cctggagggt gtggtcacca agagtcggcc tgtcatgatc   2460

atcacagagt tcatggagaa tggtgcattg gattctttcc tcaggcaaaa tgacgggcag   2520

ttcaccgtga tccagcttgt gggtatgctc aggggcatcg ctgctggcat gaagtacctg   2580

gctgagatga attatgtgca tcgggacctg gctgctagga acattctggt caacagtaac   2640

ctggtgtgca aggtgtccga ctttggcctc tcccgctacc tccaggatga cacctcagat   2700

cccacctaca ccagctcctt gggagggaag atccctgtga gatggacagc tccagaggcc   2760

atcgcctacc gcaagttcac ttcagccagc gacgtttgga gctatgggat cgtcatgtgg   2820

gaagtcatgt catttggaga gagaccctat tgggatatgt ccaaccaaga tgtcatcaat   2880

gccatcgagc aggactaccg gctgccccca cccatggact gtccagctgc tctacaccag   2940

ctcatgctgg actgttggca gaaggaccgg aacagccggc cccggtttgc ggagattgtc   3000

aacaccctag ataagatgat ccggaacccg gcaagtctca agactgtggc aaccatcacc   3060

gccgtgcctt cccagcccct gctcgaccgc tccatcccag acttcacggc ctttaccacc   3120

gtggatgact ggctcagcgc catcaaaatg gtccagtaca gggacagctt cctcactgct   3180

ggcttcacct ccctccagct ggtcacccag atgacatcag aagacctcct gagaataggc   3240

atcaccttgg caggccatca gaagaagatc ctgaacagca ttcattctat gagggtccag   3300

ataagtcagt caccaacggc aatggcatga gaactcttgt ttcttgggga aggagaggag   3360

ggaaaaggac cagggtcaag ggggaccaga ggttgaccac tgtggaatgt actggagaga   3420

ctggcttctc agctgaggaa tgcatttcca tcagtgaaga atcaaccgga cctgttgcta   3480

gcaggcaatc tccatttctc agtgacagaa gcatgtttga gatgccgtgg gaaaccaaat   3540

atataataat aaaaatataa aaaggtgatg ttcaacagaa gtgaagacaa aacaatatgc   3600

atcaggagaa caagagtaaa cccagctccc attctcagtg ggctgcagtt gcccaaccac   3660

aggaagaaag ggaaggaggt agagggaaga aacagaagca gtgttccatt ttcttcctca   3720

ccaatgacat tcttttcttt tctcctttcg tactcctccc tgagagtccc ctcccttctc   3780

ccacactcgt ttccctttgc tcatgactcc tgtagggaag tttcttcaaa caaaacccag   3840

ctcctgagtc tccagatgtt gttctgtcag ttgccaaagg actttgctga ccactgcatg   3900

gggatccaac caattcaatt aatgtcttca tattgaagaa gagatgtacc ttcaattgaa   3960

aacctcgttt ttcttttgtt tgcattttct gcaaaaagga aaaagaaacc acaaattggg   4020

gaaaaaaaaa gaagaaaaac ctgtttccgt gtgcaaaagc acacatatgt atgtctgtgt   4080

tataaaatga ctgtgcttgt tcgtaacaga tgcaaacaag aaagaagaac tgggaagtct   4140

ttgtccctag gaaatccaaa ggggctggaa tatggtgttg gtttggcttt ctggttggcc   4200

caatcggcct attggctcaa tgggaagaga ggagagggag aaaaataaaa tgaaaggaaa   4260

aaaaaaagtt tgcaaattca gacaggaaac aggtgagtgg tttgaattgg atgcagtgtg   4320

ggccatcctg gaatgatact gactgattaa ttattcctga taacatctca agaaaaggag   4380

aaggaaagtg tttctggaga atgttctttc acatcactgg aatctgcaat tcaagaagtg   4440

acaagggaga attcttgctt tacctatgga ctggcttaag ccgtgtggca tccgaggaat   4500

gtttcaaatg tgtctgtgtt tctctttaca ttccttgttg tacctcattg ttcaattcac   4560

ttttgtaaat tccacctaac atttaattat tttaaatttc tccttttacc ttaatctcct   4620

tgctaatttt atctgtctaa ttaaaaagag cagaagcatg tctgggttta cgt          4673


<210>  2303
<211>  984
<212>  PRT
<213>  Homo sapiens

<400>  2303

Met Ala Leu Asp Tyr Leu Leu Leu Leu Leu Leu Ala Ser Ala Val Ala 
1               5                   10                  15


Ala Met Glu Glu Thr Leu Met Asp Thr Arg Thr Ala Thr Ala Glu Leu 
            20                  25                  30


Gly Trp Thr Ala Asn Pro Ala Ser Gly Trp Glu Glu Val Ser Gly Tyr 
        35                  40                  45


Asp Glu Asn Leu Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val Phe 
    50                  55                  60


Glu Pro Asn Gln Asn Asn Trp Leu Leu Thr Thr Phe Ile Asn Arg Arg 
65                  70                  75                  80


Gly Ala His Arg Ile Tyr Thr Glu Met Arg Phe Thr Val Arg Asp Cys 
                85                  90                  95


Ser Ser Leu Pro Asn Val Pro Gly Ser Cys Lys Glu Thr Phe Asn Leu 
            100                 105                 110


Tyr Tyr Tyr Glu Thr Asp Ser Val Ile Ala Thr Lys Lys Ser Ala Phe 
        115                 120                 125


Trp Ser Glu Ala Pro Tyr Leu Lys Val Asp Thr Ile Ala Ala Asp Glu 
    130                 135                 140


Ser Phe Ser Gln Val Asp Phe Gly Gly Arg Leu Met Lys Val Asn Thr 
145                 150                 155                 160


Glu Val Arg Ser Phe Gly Pro Leu Thr Arg Asn Gly Phe Tyr Leu Ala 
                165                 170                 175


Phe Gln Asp Tyr Gly Ala Cys Met Ser Leu Leu Ser Val Arg Val Phe 
            180                 185                 190


Phe Lys Lys Cys Pro Ser Ile Val Gln Asn Phe Ala Val Phe Pro Glu 
        195                 200                 205


Thr Met Thr Gly Ala Glu Ser Thr Ser Leu Val Ile Ala Arg Gly Thr 
    210                 215                 220


Cys Ile Pro Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr Cys 
225                 230                 235                 240


Asn Gly Asp Gly Glu Trp Met Val Pro Ile Gly Arg Cys Thr Cys Lys 
                245                 250                 255


Pro Gly Tyr Glu Pro Glu Asn Ser Val Ala Cys Lys Ala Cys Pro Ala 
            260                 265                 270


Gly Thr Phe Lys Ala Ser Gln Glu Ala Glu Gly Cys Ser His Cys Pro 
        275                 280                 285


Ser Asn Ser Arg Ser Pro Ala Glu Ala Ser Pro Ile Cys Thr Cys Arg 
    290                 295                 300


Thr Gly Tyr Tyr Arg Ala Asp Phe Asp Pro Pro Glu Val Ala Cys Thr 
305                 310                 315                 320


Ser Val Pro Ser Gly Pro Arg Asn Val Ile Ser Ile Val Asn Glu Thr 
                325                 330                 335


Ser Ile Ile Leu Glu Trp His Pro Pro Arg Glu Thr Gly Gly Arg Asp 
            340                 345                 350


Asp Val Thr Tyr Asn Ile Ile Cys Lys Lys Cys Arg Ala Asp Arg Arg 
        355                 360                 365


Ser Cys Ser Arg Cys Asp Asp Asn Val Glu Phe Val Pro Arg Gln Leu 
    370                 375                 380


Gly Leu Thr Glu Cys Arg Val Ser Ile Ser Ser Leu Trp Ala His Thr 
385                 390                 395                 400


Pro Tyr Thr Phe Asp Ile Gln Ala Ile Asn Gly Val Ser Ser Lys Ser 
                405                 410                 415


Pro Phe Pro Pro Gln His Val Ser Val Asn Ile Thr Thr Asn Gln Ala 
            420                 425                 430


Ala Pro Ser Thr Val Pro Ile Met His Gln Val Ser Ala Thr Met Arg 
        435                 440                 445


Ser Ile Thr Leu Ser Trp Pro Gln Pro Glu Gln Pro Asn Gly Ile Ile 
    450                 455                 460


Leu Asp Tyr Glu Ile Arg Tyr Tyr Glu Lys Glu His Asn Glu Phe Asn 
465                 470                 475                 480


Ser Ser Met Ala Arg Ser Gln Thr Asn Thr Ala Arg Ile Asp Gly Leu 
                485                 490                 495


Arg Pro Gly Met Val Tyr Val Val Gln Val Arg Ala Arg Thr Val Ala 
            500                 505                 510


Gly Tyr Gly Lys Phe Ser Gly Lys Met Cys Phe Gln Thr Leu Thr Asp 
        515                 520                 525


Asp Asp Tyr Lys Ser Glu Leu Arg Glu Gln Leu Pro Leu Ile Ala Gly 
    530                 535                 540


Ser Ala Ala Ala Gly Val Val Phe Val Val Ser Leu Val Ala Ile Ser 
545                 550                 555                 560


Ile Val Cys Ser Arg Lys Arg Ala Tyr Ser Lys Glu Ala Val Tyr Ser 
                565                 570                 575


Asp Lys Leu Gln His Tyr Ser Thr Gly Arg Gly Ser Pro Gly Met Lys 
            580                 585                 590


Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg 
        595                 600                 605


Glu Phe Ala Lys Glu Ile Asp Val Ser Phe Val Lys Ile Glu Glu Val 
    610                 615                 620


Ile Gly Ala Gly Glu Phe Gly Glu Val Tyr Lys Gly Arg Leu Lys Leu 
625                 630                 635                 640


Pro Gly Lys Arg Glu Ile Tyr Val Ala Ile Lys Thr Leu Lys Ala Gly 
                645                 650                 655


Tyr Ser Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met 
            660                 665                 670


Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr 
        675                 680                 685


Lys Ser Arg Pro Val Met Ile Ile Thr Glu Phe Met Glu Asn Gly Ala 
    690                 695                 700


Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr Val Ile Gln 
705                 710                 715                 720


Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala 
                725                 730                 735


Glu Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val 
            740                 745                 750


Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Tyr 
        755                 760                 765


Leu Gln Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly 
    770                 775                 780


Lys Ile Pro Val Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys 
785                 790                 795                 800


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu 
                805                 810                 815


Val Met Ser Phe Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp 
            820                 825                 830


Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro Met Asp 
        835                 840                 845


Cys Pro Ala Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Asp 
    850                 855                 860


Arg Asn Ser Arg Pro Arg Phe Ala Glu Ile Val Asn Thr Leu Asp Lys 
865                 870                 875                 880


Met Ile Arg Asn Pro Ala Ser Leu Lys Thr Val Ala Thr Ile Thr Ala 
                885                 890                 895


Val Pro Ser Gln Pro Leu Leu Asp Arg Ser Ile Pro Asp Phe Thr Ala 
            900                 905                 910


Phe Thr Thr Val Asp Asp Trp Leu Ser Ala Ile Lys Met Val Gln Tyr 
        915                 920                 925


Arg Asp Ser Phe Leu Thr Ala Gly Phe Thr Ser Leu Gln Leu Val Thr 
    930                 935                 940


Gln Met Thr Ser Glu Asp Leu Leu Arg Ile Gly Ile Thr Leu Ala Gly 
945                 950                 955                 960


His Gln Lys Lys Ile Leu Asn Ser Ile His Ser Met Arg Val Gln Ile 
                965                 970                 975


Ser Gln Ser Pro Thr Ala Met Ala 
            980


<210>  2304
<211>  4955
<212>  DNA
<213>  Homo sapiens

<400>  2304
gtcagtctgg ccggctccgt cctcccgtag gctccgctgt agctagcaat gtgacaccag     60

gacgcactcg ctctcgcgcg ctctcccagg ctcgttctcc ctcgccctct ctctctcaca    120

cacgcacgca cacacccacc tctcccataa acacacacac acacatgcac acccacaccc    180

acgcgcgccc gcaccgcccc acgcgcacac actcctgccc acgcccacgc agcgctccgg    240

gaagtccggt ccgggcgaga gcgcgaaagg ataccgagaa gccacccgcg gagagcgcag    300

cggcgccctg ggacgcggcg ctctcccggc gctgctgcct cggcttggtc tcggcctgcg    360

ggccgtcggc cggcgatggc cctggattat ctactactgc tcctcctggc atccgcagtg    420

gctgcgatgg aagaaacgtt aatggacacc agaacggcta ctgcagagct gggctggacg    480

gccaatcctg cgtccgggtg ggaagaagtc agtggctacg atgaaaacct gaacaccatc    540

cgcacctacc aggtgtgcaa tgtcttcgag cccaaccaga acaattggct gctcaccacc    600

ttcatcaacc ggcggggggc ccatcgcatc tacacagaga tgcgcttcac tgtgagagac    660

tgcagcagcc tccctaatgt cccaggatcc tgcaaggaga ccttcaactt gtattactat    720

gagactgact ctgtcattgc caccaagaag tcagccttct ggtctgaggc cccctacctc    780

aaagtagaca ccattgctgc agatgagagc ttctcccagg tggactttgg gggaaggctg    840

atgaaggtaa acacagaagt caggagcttt gggcctctta ctcggaatgg tttttacctc    900

gcttttcagg attatggagc ctgtatgtct cttctttctg tccgtgtctt cttcaaaaag    960

tgtcccagca ttgtgcaaaa ttttgcagtg tttccagaga ctatgacagg ggcagagagc   1020

acatctctgg tgattgctcg gggcacatgc atccccaacg cagaggaagt ggacgtgccc   1080

atcaaactct actgcaacgg ggatggggaa tggatggtgc ctattgggcg atgcacctgc   1140

aagcctggct atgagcctga gaacagcgtg gcatgcaagg cttgccctgc agggacattc   1200

aaggccagcc aggaagctga aggctgctcc cactgcccct ccaacagccg ctcccctgca   1260

gaggcgtctc ccatctgcac ctgtcggacc ggttattacc gagcggactt tgaccctcca   1320

gaagtggcat gcactagcgt cccatcaggt ccccgcaatg ttatctccat cgtcaatgag   1380

acgtccatca ttctggagtg gcaccctcca agggagacag gtgggcggga tgatgtgacc   1440

tacaacatca tctgcaaaaa gtgccgggca gaccgccgga gctgctcccg ctgtgacgac   1500

aatgtggagt ttgtgcccag gcagctgggc ctgacggagt gccgcgtctc catcagcagc   1560

ctgtgggccc acacccccta cacctttgac atccaggcca tcaatggagt ctccagcaag   1620

agtcccttcc ccccacagca cgtctctgtc aacatcacca caaaccaagc cgccccctcc   1680

accgttccca tcatgcacca agtcagtgcc actatgagga gcatcacctt gtcatggcca   1740

cagccggagc agcccaatgg catcatcctg gactatgaga tccggtacta tgagaaggaa   1800

cacaatgagt tcaactcctc catggccagg agtcagacca acacagcaag gattgatggg   1860

ctgcggcctg gcatggtata tgtggtacag gtgcgtgccc gcactgttgc tggctacggc   1920

aagttcagtg gcaagatgtg cttccagact ctgactgacg atgattacaa gtcagagctg   1980

agggagcagc tgcccctgat tgctggctcg gcagcggccg gggtcgtgtt cgttgtgtcc   2040

ttggtggcca tctctatcgt ctgtagcagg aaacgggctt atagcaaaga ggctgtgtac   2100

agcgataagc tccagcatta cagcacaggc cgaggctccc cagggatgaa gatctacatt   2160

gaccccttca cttacgagga tcccaacgaa gctgtccggg agtttgccaa ggagattgat   2220

gtatcttttg tgaaaattga agaggtcatc ggagcagggg agtttggaga agtgtacaag   2280

gggcgtttga aactgccagg caagagggaa atctacgtgg ccatcaagac cctgaaggca   2340

gggtactcgg agaagcagcg tcgggacttt ctgagtgagg cgagcatcat gggccagttc   2400

gaccatccta acatcattcg cctggagggt gtggtcacca agagtcggcc tgtcatgatc   2460

atcacagagt tcatggagaa tggtgcattg gattctttcc tcaggcaaaa tgacgggcag   2520

ttcaccgtga tccagcttgt gggtatgctc aggggcatcg ctgctggcat gaagtacctg   2580

gctgagatga attatgtgca tcgggacctg gctgctagga acattctggt caacagtaac   2640

ctggtgtgca aggtgtccga ctttggcctc tcccgctacc tccaggatga cacctcagat   2700

cccacctaca ccagctcctt gggagggaag atccctgtga gatggacagc tccagaggcc   2760

atcgcctacc gcaagttcac ttcagccagc gacgtttgga gctatgggat cgtcatgtgg   2820

gaagtcatgt catttggaga gagaccctat tgggatatgt ccaaccaaga tgtcatcaat   2880

gccatcgagc aggactaccg gctgccccca cccatggact gtccagctgc tctacaccag   2940

ctcatgctgg actgttggca gaaggaccgg aacagccggc cccggtttgc ggagattgtc   3000

aacaccctag ataagatgat ccggaacccg gcaagtctca agactgtggc aaccatcacc   3060

gccgtgcctt cccagcccct gctcgaccgc tccatcccag acttcacggc ctttaccacc   3120

gtggatgact ggctcagcgc catcaaaatg gtccagtaca gggacagctt cctcactgct   3180

ggcttcacct ccctccagct ggtcacccag atgacatcag aagacctcct gagaataggc   3240

atcaccttgg caggccatca gaagaagatc ctgaacagca ttcattctat gagggtccag   3300

ataagtcagt caccaacggc aatggcatga gaactcttgt ttcttgggga aggagaggag   3360

ggaaaaggac cagggtcaag ggggaccaga ggttgaccac tgtggaatgt actggagaga   3420

ctggcttctc agctgaggaa tgcatttcca tcagtgaaga atcaaccgga cctgttgcta   3480

gcaggcaatc tccatttctc agtgacagaa gcatgtttga gatgccgtgg gaaaccaaat   3540

atataataat aaaaatataa aaaggtgatg ttcaacagaa gtgaagacaa aacaatatgc   3600

atcaggagaa caagagtaaa cccagctccc attctcagtg ggctgcagtt gcccaaccac   3660

aggaagaaag ggaaggaggt agagggaaga aacagaagca gtgttccatt ttcttcctca   3720

ccaatgacat tcttttcttt tctcctttcg tactcctccc tgagagtccc ctcccttctc   3780

ccacactcgt ttccctttgc tcatgactcc tgtagggaag tttcttcaaa caaaacccag   3840

ctcctgagtc tccagatgtt gttctgtcag ttgccaaagg actttgctga ccactgcatg   3900

gggatccaac caattcaatt aatgtcttca tattgaagaa gagatgtacc ttcaattgaa   3960

aacctcgttt ttcttttgtt tgcattttct gcaaaaagga aaaagaaacc acaaattggg   4020

gaaaaaaaaa gaagaaaaac ctgtttccgt gtgcaaaagc acacatatgt atgtctgtgt   4080

tataaaatga ctgtgcttgt tcgtaacaga tgcaaacaag aaagaagaac tgggaagtct   4140

ttgtccctag gaaatccaaa ggggctggaa tatggtgttg gtttggcttt ctggttggcc   4200

caatcggcct attggctcaa tgggaagaga ggagagggag aaaaataaaa tgaaaggaaa   4260

aaaaaaagtt tgcaaattca gacaggaaac aggtgagtgg tttgaattgg atgcagtgtg   4320

ggccatcctg gaatgatact gactgattaa ttattcctga taacatctca agaaaaggag   4380

aaggaaagtg tttctggaga atgttctttc acatcactgg aatctgcaat tcaagaagtg   4440

acaagggaga attcttgctt tacctatgga ctggcttaag ccgtgtggca tccgaggaat   4500

gtttcaaatg tgtctgtgtt tctctttaca ttccttgttg tacctcattg ttcaattcac   4560

ttttgtaaat tccacctaac atttaattat tttaaatttc tccttttacc ttaatctcct   4620

tgctaatttt atctgtctaa ttaaaaagag cagaagcatg tctgggttta cgtaaaatgg   4680

tgtcagagtg tgtatccctg gatcccagag ggttgtcccc aaatttcagg agaatcctta   4740

acaactgtcc ttcttctttc taatgtggga gggagggaac acatccttga ccccatgaat   4800

gccaagaagc agaatgtagt aaactctctg gcactgacgt gatccaaagg aaaaactgaa   4860

taaataaggc ttaagaagtc gctggcaaat aaacataaac aatcaccatg aatacactat   4920

caaccctgat tttagtttac gcactgcatt tgaga                              4955


<210>  2305
<211>  984
<212>  PRT
<213>  Homo sapiens

<400>  2305

Met Ala Leu Asp Tyr Leu Leu Leu Leu Leu Leu Ala Ser Ala Val Ala 
1               5                   10                  15


Ala Met Glu Glu Thr Leu Met Asp Thr Arg Thr Ala Thr Ala Glu Leu 
            20                  25                  30


Gly Trp Thr Ala Asn Pro Ala Ser Gly Trp Glu Glu Val Ser Gly Tyr 
        35                  40                  45


Asp Glu Asn Leu Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val Phe 
    50                  55                  60


Glu Pro Asn Gln Asn Asn Trp Leu Leu Thr Thr Phe Ile Asn Arg Arg 
65                  70                  75                  80


Gly Ala His Arg Ile Tyr Thr Glu Met Arg Phe Thr Val Arg Asp Cys 
                85                  90                  95


Ser Ser Leu Pro Asn Val Pro Gly Ser Cys Lys Glu Thr Phe Asn Leu 
            100                 105                 110


Tyr Tyr Tyr Glu Thr Asp Ser Val Ile Ala Thr Lys Lys Ser Ala Phe 
        115                 120                 125


Trp Ser Glu Ala Pro Tyr Leu Lys Val Asp Thr Ile Ala Ala Asp Glu 
    130                 135                 140


Ser Phe Ser Gln Val Asp Phe Gly Gly Arg Leu Met Lys Val Asn Thr 
145                 150                 155                 160


Glu Val Arg Ser Phe Gly Pro Leu Thr Arg Asn Gly Phe Tyr Leu Ala 
                165                 170                 175


Phe Gln Asp Tyr Gly Ala Cys Met Ser Leu Leu Ser Val Arg Val Phe 
            180                 185                 190


Phe Lys Lys Cys Pro Ser Ile Val Gln Asn Phe Ala Val Phe Pro Glu 
        195                 200                 205


Thr Met Thr Gly Ala Glu Ser Thr Ser Leu Val Ile Ala Arg Gly Thr 
    210                 215                 220


Cys Ile Pro Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr Cys 
225                 230                 235                 240


Asn Gly Asp Gly Glu Trp Met Val Pro Ile Gly Arg Cys Thr Cys Lys 
                245                 250                 255


Pro Gly Tyr Glu Pro Glu Asn Ser Val Ala Cys Lys Ala Cys Pro Ala 
            260                 265                 270


Gly Thr Phe Lys Ala Ser Gln Glu Ala Glu Gly Cys Ser His Cys Pro 
        275                 280                 285


Ser Asn Ser Arg Ser Pro Ala Glu Ala Ser Pro Ile Cys Thr Cys Arg 
    290                 295                 300


Thr Gly Tyr Tyr Arg Ala Asp Phe Asp Pro Pro Glu Val Ala Cys Thr 
305                 310                 315                 320


Ser Val Pro Ser Gly Pro Arg Asn Val Ile Ser Ile Val Asn Glu Thr 
                325                 330                 335


Ser Ile Ile Leu Glu Trp His Pro Pro Arg Glu Thr Gly Gly Arg Asp 
            340                 345                 350


Asp Val Thr Tyr Asn Ile Ile Cys Lys Lys Cys Arg Ala Asp Arg Arg 
        355                 360                 365


Ser Cys Ser Arg Cys Asp Asp Asn Val Glu Phe Val Pro Arg Gln Leu 
    370                 375                 380


Gly Leu Thr Glu Cys Arg Val Ser Ile Ser Ser Leu Trp Ala His Thr 
385                 390                 395                 400


Pro Tyr Thr Phe Asp Ile Gln Ala Ile Asn Gly Val Ser Ser Lys Ser 
                405                 410                 415


Pro Phe Pro Pro Gln His Val Ser Val Asn Ile Thr Thr Asn Gln Ala 
            420                 425                 430


Ala Pro Ser Thr Val Pro Ile Met His Gln Val Ser Ala Thr Met Arg 
        435                 440                 445


Ser Ile Thr Leu Ser Trp Pro Gln Pro Glu Gln Pro Asn Gly Ile Ile 
    450                 455                 460


Leu Asp Tyr Glu Ile Arg Tyr Tyr Glu Lys Glu His Asn Glu Phe Asn 
465                 470                 475                 480


Ser Ser Met Ala Arg Ser Gln Thr Asn Thr Ala Arg Ile Asp Gly Leu 
                485                 490                 495


Arg Pro Gly Met Val Tyr Val Val Gln Val Arg Ala Arg Thr Val Ala 
            500                 505                 510


Gly Tyr Gly Lys Phe Ser Gly Lys Met Cys Phe Gln Thr Leu Thr Asp 
        515                 520                 525


Asp Asp Tyr Lys Ser Glu Leu Arg Glu Gln Leu Pro Leu Ile Ala Gly 
    530                 535                 540


Ser Ala Ala Ala Gly Val Val Phe Val Val Ser Leu Val Ala Ile Ser 
545                 550                 555                 560


Ile Val Cys Ser Arg Lys Arg Ala Tyr Ser Lys Glu Ala Val Tyr Ser 
                565                 570                 575


Asp Lys Leu Gln His Tyr Ser Thr Gly Arg Gly Ser Pro Gly Met Lys 
            580                 585                 590


Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg 
        595                 600                 605


Glu Phe Ala Lys Glu Ile Asp Val Ser Phe Val Lys Ile Glu Glu Val 
    610                 615                 620


Ile Gly Ala Gly Glu Phe Gly Glu Val Tyr Lys Gly Arg Leu Lys Leu 
625                 630                 635                 640


Pro Gly Lys Arg Glu Ile Tyr Val Ala Ile Lys Thr Leu Lys Ala Gly 
                645                 650                 655


Tyr Ser Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met 
            660                 665                 670


Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr 
        675                 680                 685


Lys Ser Arg Pro Val Met Ile Ile Thr Glu Phe Met Glu Asn Gly Ala 
    690                 695                 700


Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr Val Ile Gln 
705                 710                 715                 720


Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala 
                725                 730                 735


Glu Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val 
            740                 745                 750


Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Tyr 
        755                 760                 765


Leu Gln Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly 
    770                 775                 780


Lys Ile Pro Val Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys 
785                 790                 795                 800


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu 
                805                 810                 815


Val Met Ser Phe Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp 
            820                 825                 830


Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro Met Asp 
        835                 840                 845


Cys Pro Ala Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Asp 
    850                 855                 860


Arg Asn Ser Arg Pro Arg Phe Ala Glu Ile Val Asn Thr Leu Asp Lys 
865                 870                 875                 880


Met Ile Arg Asn Pro Ala Ser Leu Lys Thr Val Ala Thr Ile Thr Ala 
                885                 890                 895


Val Pro Ser Gln Pro Leu Leu Asp Arg Ser Ile Pro Asp Phe Thr Ala 
            900                 905                 910


Phe Thr Thr Val Asp Asp Trp Leu Ser Ala Ile Lys Met Val Gln Tyr 
        915                 920                 925


Arg Asp Ser Phe Leu Thr Ala Gly Phe Thr Ser Leu Gln Leu Val Thr 
    930                 935                 940


Gln Met Thr Ser Glu Asp Leu Leu Arg Ile Gly Ile Thr Leu Ala Gly 
945                 950                 955                 960


His Gln Lys Lys Ile Leu Asn Ser Ile His Ser Met Arg Val Gln Ile 
                965                 970                 975


Ser Gln Ser Pro Thr Ala Met Ala 
            980


<210>  2306
<211>  970
<212>  DNA
<213>  Homo sapiens

<400>  2306
ctccagctcg cagtccacgg gctagtggac tctgcttggc gtgcaagcac tgcgcgcggg     60

ggccggagaa gctctgccgt ggtatcccgc aagtggccgc cgaaggagag gggtggagtt    120

cattggccgt acccttgggg accagtctgg tggtccgggc gcctgcggga ctgcaggttt    180

ccagggtcag tcggggagag gtggaaaccc ttttcgcctc ttgagccttg gaacaggagt    240

gggctgggaa acgttaatgg acaccagaac ggctactgca gagctgggct ggacggccaa    300

tcctgcgtcc gggtgggaag aagtcagtgg ctacgatgaa aacctgaaca ccatccgcac    360

ctaccaggtg tgcaatgtct tcgagcccaa ccagaacaat tggctgctca ccaccttcat    420

caaccggcgg ggggcccatc gcatctacac agagatgcgc ttcactgtga gagactgcag    480

cagcctccct aatgtcccag gatcctgcaa ggagaccttc aacttgtatt actatgagac    540

tgactctgtc attgccacca agaagtcagc cttctggtct gaggccccct acctcaaagt    600

agacaccatt gctgcagatg agagcttctc ccaggtggac tttgggggaa ggctgatgaa    660

ggtaaacaca gaagtcagga gctttgggcc tcttactcgg aatggttttt acctcgcttt    720

tcaggattat ggagcctgta tgtctcttct ttctgtccgt gtcttcttca aaaagtgtcc    780

cagcattgtg caaaattttg cagtgtttcc agagactatg acaggggcag agagcacatc    840

tctggtgatt gctcggggca catgcatccc caacgcagag gaagtggacg tgcccatcaa    900

actctactgc aacggggatg gggaatggat ggtgcctatt gggcgatgca cctgcaagcc    960

tggctatgag                                                           970


<210>  2307
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  2307

Met Asp Thr Arg Thr Ala Thr Ala Glu Leu Gly Trp Thr Ala Asn Pro 
1               5                   10                  15


Ala Ser Gly Trp Glu Glu Val Ser Gly Tyr Asp Glu Asn Leu Asn Thr 
            20                  25                  30


Ile Arg Thr Tyr Gln Val Cys Asn Val Phe Glu Pro Asn Gln Asn Asn 
        35                  40                  45


Trp Leu Leu Thr Thr Phe Ile Asn Arg Arg Gly Ala His Arg Ile Tyr 
    50                  55                  60


Thr Glu Met Arg Phe Thr Val Arg Asp Cys Ser Ser Leu Pro Asn Val 
65                  70                  75                  80


Pro Gly Ser Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr Glu Thr Asp 
                85                  90                  95


Ser Val Ile Ala Thr Lys Lys Ser Ala Phe Trp Ser Glu Ala Pro Tyr 
            100                 105                 110


Leu Lys Val Asp Thr Ile Ala Ala Asp Glu Ser Phe Ser Gln Val Asp 
        115                 120                 125


Phe Gly Gly Arg Leu Met Lys Val Asn Thr Glu Val Arg Ser Phe Gly 
    130                 135                 140


Pro Leu Thr Arg Asn Gly Phe Tyr Leu Ala Phe Gln Asp Tyr Gly Ala 
145                 150                 155                 160


Cys Met Ser Leu Leu Ser Val Arg Val Phe Phe Lys Lys Cys Pro Ser 
                165                 170                 175


Ile Val Gln Asn Phe Ala Val Phe Pro Glu Thr Met Thr Gly Ala Glu 
            180                 185                 190


Ser Thr Ser Leu Val Ile Ala Arg Gly Thr Cys Ile Pro Asn Ala Glu 
        195                 200                 205


Glu Val Asp Val Pro Ile Lys Leu Tyr Cys Asn Gly Asp Gly Glu Trp 
    210                 215                 220


Met Val Pro Ile Gly Arg Cys Thr Cys Lys Pro Gly Tyr 
225                 230                 235


<210>  2308
<211>  698
<212>  DNA
<213>  Homo sapiens

<400>  2308
gctgatggca tctcaccaaa atgcggtgca ataaaagcaa atccttgaag agtggaaacc     60

ttgcagccag gttcatggaa gggctcaaga atattgctgt gctacggtgc ttctgcaggc    120

aggttcacca tctgtgtaac tgtggctacc accttccatc ttgaactcag acacagacct    180

ctcctccgag ctccagatcc atatatccaa tctccttctc aatagtcact tgcaagtctc    240

agccatttca aagtcaaccc aaagtggtaa tcttcaaatc tttcccattt caacaagtga    300

caccaccatc cactaattgt aaaagtcaga aacctggatg ccatctttgc tccactgtga    360

gaggctgctc acaccacccc ctacatgccc tgaggagtct ccaggggcac ccacagcctc    420

ctctggcttt ctctgggtga cccagggagg gctaggccct gtgagccaca ccggggcagc    480

agcactcacc agctcacaag tgcttccctc ttctgccttt gctgacaaca gtcccccagg    540

ccttccattc tccttccgat gaggctgatg tattctgttg cagttggatg cacctacaaa    600

aatcctcttc aaaatcccat cacttcacca ccaaggaatt actaaaatac catgaaggag    660

gtgctcaaag gcgatatggg gcagaggaag gaataagt                            698


<210>  2309
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  2309

Met Pro Ser Leu Leu His Cys Glu Arg Leu Leu Thr Pro Pro Pro Thr 
1               5                   10                  15


Cys Pro Glu Glu Ser Pro Gly Ala Pro Thr Ala Ser Ser Gly Phe Leu 
            20                  25                  30


Trp Val Thr Gln Gly Gly Leu Gly Pro Val Ser His Thr Gly Ala Ala 
        35                  40                  45


Ala Leu Thr Ser Ser Gln Val Leu Pro Ser Ser Ala Phe Ala Asp Asn 
    50                  55                  60


Ser Pro Pro Gly Leu Pro Phe Ser Phe Arg 
65                  70


<210>  2310
<211>  539
<212>  DNA
<213>  Homo sapiens

<400>  2310
agttgctaac attcaggcca ggtgttgacc aggaagtgaa gcgagattat taagagtaca     60

cttacacaca gcaagctgca tcacaagtgc ctcagaatgc ttgaaaatga ggtcctatct    120

ggcacagctg cccagggttt gccttacctg ttcacatctg tgggttctct gtgatcaaga    180

actgcctgcc ctgggaaatc catttgtttt cctccactca gtgccaaatg ccttcgtctt    240

tgtttctgca agctctcaac attcactgca ggctctaacc caatgacaag tctttagaag    300

agaagagagg gaaaaataga cagaaacaca ccaaggagaa gacaatgtga agacagaggc    360

agatattgga gtgatgcatc tacaggccaa ggaatgccaa gaattgccag cagccaccag    420

aagccaggag ataacagatt ctctgttcga gcctccagaa ggatccaatg cagctgacac    480

cttgatttca gacttctggc ctccagaact gtgagaataa atatctgatg ttttaaact     539


<210>  2311
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  2311

Met Arg Ser Tyr Leu Ala Gln Leu Pro Arg Val Cys Leu Thr Cys Ser 
1               5                   10                  15


His Leu Trp Val Leu Cys Asp Gln Glu Leu Pro Ala Leu Gly Asn Pro 
            20                  25                  30


Phe Val Phe Leu His Ser Val Pro Asn Ala Phe Val Phe Val Ser Ala 
        35                  40                  45


Ser Ser Gln His Ser Leu Gln Ala Leu Thr Gln 
    50                  55


<210>  2312
<211>  2634
<212>  DNA
<213>  Homo sapiens

<400>  2312
cttggtagga ggaatgaaat ctgatttgca gcagccggtc tttcttttga gaaaattatc     60

agactcattg ataagggaaa ttaaatattg accaaggaca atgtctttat ttctcagtaa    120

cttatcaaca aatgactcta gcctgtggaa agagaatcat aattctacgg accttttaaa    180

tccgccagga accctgaata tctatctttt ttgcttgaca tgtctcatga cttttgcagc    240

cttggtgggc agcatttatt cactaatttc cctgctgaaa atgcagaaca gaactgttgt    300

gtccatgctt gtggcttcct ggtctgtgga tgatctcatg agcgtcctgt cggtgaccat    360

cttcatgttt ttgcagtggc caaacgaggt ccccggttac ttccaatttc tgtgcaccac    420

ctctgcctta atgtatttat gccagggcct ctctagcaac ttgaaggcga ctctcctagt    480

ctcttacaac ttttatacga tgcacagagg tgtggggagc cagacagcct ccagaagatc    540

gggccaggtg ctcggcgtgg tgctgaccgt gtgggcagcc agtctgctgc tctcggcgct    600

cccgctgtgc ggctggggcg ccttcgtgcg cacgccctgg ggctgcctgg tggactgctc    660

cagctcctac gtactattcc tctctatcgt gtacgctttg gccttcggac tcctcgtggg    720

cctctcagtc ccactcactc accgattgct gtgttcggag gagccgccga gactccactc    780

caactaccag gaaatttccc gtggagcttc aattcctggg acccctccta ctgcggggag    840

agtggtttcc ctgtccccag aggatgctcc aggcccgagt ctgcggcgct ctgggggatg    900

ctctccgagc tccgacaccg tgttcggacc gggtgcgccc gctgccgctg gggctgaagc    960

ctgcaggcgt gagaaccggg ggactctcta tggcaccagg agcttcaccg tgagcgtagc   1020

gcagaagcgc ttcgctttga tcctagcgct tacaaaagtc gtcctttggc tgcccatgat   1080

gatgcacatg gtggtccaga acgtcgtggg gtttcagagc cttcccttgg agacattcag   1140

ctttctactt accctgctgg ccaccactgt aaccccagtg tttgtcttgt ccaaacgctg   1200

gacccacttg ccctgtggct gcatcatcaa ctgcaggcag aacgcatatg cagtggcgtc   1260

cgatgggaaa aaaatcaaga gaaaaggctt tgaattcaat ctatcattcc aaaaaagtta   1320

tgggatttat aaaatagcac atgaagatta ctatgatgat gatgaaaatt ccatattcta   1380

tcacaacctg atgaactctg agtgtgaaac tacaaaagac cctcagagag acaaccgtaa   1440

catcttcaat gctataaaag tagaaatcag caccacgccc tctctggaca gctccacaca   1500

aagaggcatc aacaaatgca caaatactga tattacagaa gctaaacagg attccaacaa   1560

caaaaaggat gcgttttctg acaaaacagg aggtgatatt aactatgaag aaactacctt   1620

ttctgaaggg ccagaaagaa gactgtctca tgaagagagt cagaaaccag atctttcaga   1680

ctgggagtgg tgtaggagta aatcagaaag aacccctcgt cagcgttccg gttatgccct   1740

tgccattccc ttgtgtgcat tccaggggac tgtgtctctc catgcaccta cagggaaaac   1800

cctatctctt tctacctatg aggtaagcgc agaagggcaa aaaataactc cagcctctaa   1860

gaaaatagaa gtctatcgat ccaaaagtgt tggccatgaa ccaaactcag aagattcttc   1920

atccacgttt gtggacacca gtgtgaaaat acacttggag gttcttgaaa tttgtgataa   1980

tgaagaggcc ttggacactg tgtcaatcat tagtaacatc agtcagtcct ccacacaagt   2040

cagatctcca tccctacgtt actccaggaa agaaaacaga tttgtttcat gtgacctagg   2100

ggaaacagcc tcatactccc tctttttgcc caccagtaat cctgatggtg atattaatat   2160

ctccattcca gacacagtag aagcacacag gcagaacagt aaaaggcagc atcaagagag   2220

ggatggctac caggaggaaa tccagttgtt aaataaagct tacagaaaaa gagaggaaga   2280

aagcaagggt agttagtggg tatttggtct aacaggagca agaatggatc tgcaacgtca   2340

actgtgaaac taacaccttt gttatgagac tgatttcctt ttatttgttg gcttacatta   2400

gttttactga tttaatagtt aatttttttg tgggaacaac tggaactagt gtaaacactt   2460

aagtgcattt gatgtgttac ctaaagatca cacactgtgg taatgaaaag attttacttc   2520

ttatctgact tctaaaaaat attttctaaa tcaaatcttg gcctagttta ccaatgtttt   2580

tgcttgtcaa cttcctagta aacagaaaat tgtataaact cagtgaatat actg         2634


<210>  2313
<211>  731
<212>  PRT
<213>  Homo sapiens

<400>  2313

Met Ser Leu Phe Leu Ser Asn Leu Ser Thr Asn Asp Ser Ser Leu Trp 
1               5                   10                  15


Lys Glu Asn His Asn Ser Thr Asp Leu Leu Asn Pro Pro Gly Thr Leu 
            20                  25                  30


Asn Ile Tyr Leu Phe Cys Leu Thr Cys Leu Met Thr Phe Ala Ala Leu 
        35                  40                  45


Val Gly Ser Ile Tyr Ser Leu Ile Ser Leu Leu Lys Met Gln Asn Arg 
    50                  55                  60


Thr Val Val Ser Met Leu Val Ala Ser Trp Ser Val Asp Asp Leu Met 
65                  70                  75                  80


Ser Val Leu Ser Val Thr Ile Phe Met Phe Leu Gln Trp Pro Asn Glu 
                85                  90                  95


Val Pro Gly Tyr Phe Gln Phe Leu Cys Thr Thr Ser Ala Leu Met Tyr 
            100                 105                 110


Leu Cys Gln Gly Leu Ser Ser Asn Leu Lys Ala Thr Leu Leu Val Ser 
        115                 120                 125


Tyr Asn Phe Tyr Thr Met His Arg Gly Val Gly Ser Gln Thr Ala Ser 
    130                 135                 140


Arg Arg Ser Gly Gln Val Leu Gly Val Val Leu Thr Val Trp Ala Ala 
145                 150                 155                 160


Ser Leu Leu Leu Ser Ala Leu Pro Leu Cys Gly Trp Gly Ala Phe Val 
                165                 170                 175


Arg Thr Pro Trp Gly Cys Leu Val Asp Cys Ser Ser Ser Tyr Val Leu 
            180                 185                 190


Phe Leu Ser Ile Val Tyr Ala Leu Ala Phe Gly Leu Leu Val Gly Leu 
        195                 200                 205


Ser Val Pro Leu Thr His Arg Leu Leu Cys Ser Glu Glu Pro Pro Arg 
    210                 215                 220


Leu His Ser Asn Tyr Gln Glu Ile Ser Arg Gly Ala Ser Ile Pro Gly 
225                 230                 235                 240


Thr Pro Pro Thr Ala Gly Arg Val Val Ser Leu Ser Pro Glu Asp Ala 
                245                 250                 255


Pro Gly Pro Ser Leu Arg Arg Ser Gly Gly Cys Ser Pro Ser Ser Asp 
            260                 265                 270


Thr Val Phe Gly Pro Gly Ala Pro Ala Ala Ala Gly Ala Glu Ala Cys 
        275                 280                 285


Arg Arg Glu Asn Arg Gly Thr Leu Tyr Gly Thr Arg Ser Phe Thr Val 
    290                 295                 300


Ser Val Ala Gln Lys Arg Phe Ala Leu Ile Leu Ala Leu Thr Lys Val 
305                 310                 315                 320


Val Leu Trp Leu Pro Met Met Met His Met Val Val Gln Asn Val Val 
                325                 330                 335


Gly Phe Gln Ser Leu Pro Leu Glu Thr Phe Ser Phe Leu Leu Thr Leu 
            340                 345                 350


Leu Ala Thr Thr Val Thr Pro Val Phe Val Leu Ser Lys Arg Trp Thr 
        355                 360                 365


His Leu Pro Cys Gly Cys Ile Ile Asn Cys Arg Gln Asn Ala Tyr Ala 
    370                 375                 380


Val Ala Ser Asp Gly Lys Lys Ile Lys Arg Lys Gly Phe Glu Phe Asn 
385                 390                 395                 400


Leu Ser Phe Gln Lys Ser Tyr Gly Ile Tyr Lys Ile Ala His Glu Asp 
                405                 410                 415


Tyr Tyr Asp Asp Asp Glu Asn Ser Ile Phe Tyr His Asn Leu Met Asn 
            420                 425                 430


Ser Glu Cys Glu Thr Thr Lys Asp Pro Gln Arg Asp Asn Arg Asn Ile 
        435                 440                 445


Phe Asn Ala Ile Lys Val Glu Ile Ser Thr Thr Pro Ser Leu Asp Ser 
    450                 455                 460


Ser Thr Gln Arg Gly Ile Asn Lys Cys Thr Asn Thr Asp Ile Thr Glu 
465                 470                 475                 480


Ala Lys Gln Asp Ser Asn Asn Lys Lys Asp Ala Phe Ser Asp Lys Thr 
                485                 490                 495


Gly Gly Asp Ile Asn Tyr Glu Glu Thr Thr Phe Ser Glu Gly Pro Glu 
            500                 505                 510


Arg Arg Leu Ser His Glu Glu Ser Gln Lys Pro Asp Leu Ser Asp Trp 
        515                 520                 525


Glu Trp Cys Arg Ser Lys Ser Glu Arg Thr Pro Arg Gln Arg Ser Gly 
    530                 535                 540


Tyr Ala Leu Ala Ile Pro Leu Cys Ala Phe Gln Gly Thr Val Ser Leu 
545                 550                 555                 560


His Ala Pro Thr Gly Lys Thr Leu Ser Leu Ser Thr Tyr Glu Val Ser 
                565                 570                 575


Ala Glu Gly Gln Lys Ile Thr Pro Ala Ser Lys Lys Ile Glu Val Tyr 
            580                 585                 590


Arg Ser Lys Ser Val Gly His Glu Pro Asn Ser Glu Asp Ser Ser Ser 
        595                 600                 605


Thr Phe Val Asp Thr Ser Val Lys Ile His Leu Glu Val Leu Glu Ile 
    610                 615                 620


Cys Asp Asn Glu Glu Ala Leu Asp Thr Val Ser Ile Ile Ser Asn Ile 
625                 630                 635                 640


Ser Gln Ser Ser Thr Gln Val Arg Ser Pro Ser Leu Arg Tyr Ser Arg 
                645                 650                 655


Lys Glu Asn Arg Phe Val Ser Cys Asp Leu Gly Glu Thr Ala Ser Tyr 
            660                 665                 670


Ser Leu Phe Leu Pro Thr Ser Asn Pro Asp Gly Asp Ile Asn Ile Ser 
        675                 680                 685


Ile Pro Asp Thr Val Glu Ala His Arg Gln Asn Ser Lys Arg Gln His 
    690                 695                 700


Gln Glu Arg Asp Gly Tyr Gln Glu Glu Ile Gln Leu Leu Asn Lys Ala 
705                 710                 715                 720


Tyr Arg Lys Arg Glu Glu Glu Ser Lys Gly Ser 
                725                 730


<210>  2314
<211>  1730
<212>  DNA
<213>  Homo sapiens

<400>  2314
ttattcacag aagaaagcag gtagtatact gttacaatac tacagtagaa agtcagaagg     60

tcacaaagct tgcagggtaa gtgacacaac ttgaaactgc ttggccctct ttaaaaagaa    120

ataataaaat gggagagaat gaagcaagtt tacctaacac gtctttgcaa ggtaaaaaga    180

tggcctatca gaaggtccat gcagatcaaa gagctccagg acactcacag tacttagaca    240

atgatgacct tcaagccact gcccttgact tagagtggga catggagaag gaactagagg    300

agtctggttt tgaccaattc cagctagacg gtgctgagaa tcagaaccta gggcattcag    360

agactataga cctcaatctt gattccattc aaccagcaac ttcacccaaa ggaaggttcc    420

agagacttca agaagaatct gactacatta cccattatac acgatctgca ccaaagagca    480

atcgctgcaa cttttgccac gtcttaaaaa tactttgcac agccaccatt ttatttattt    540

ttgggatttt gataggttat tatgtacata caaattgccc ttcagatgct ccatcttcag    600

gaacagttga tcctcagtta tatcaagaga ttctcaagac aatccaggca gaagatatta    660

agaagtcttt cagaaatttg gtacaactat ataaaaatga agatgacatg gaaatttcaa    720

agaagattaa gactcagtgg acctctttgg gcctagaaga tgtacagttt gtaaattact    780

ctgtgctgct tgatctgcca ggcccttctc ccagcactgt gactctgagc agcagtggtc    840

aatgctttca tcctaatggc cagccttgca gtgaagaagc cagaaaagat agcagccaag    900

acctgctcta ttcatatgca gcctattctg ccaaaggaac tctcaaggct gaagtcatcg    960

atgtgagtta tggaatggca gatgatttaa aaaggattag gaaaataaaa aacgtaacaa   1020

atcagatcgc actcctgaaa ttaggaaaat tgccactgct ttataaggtt ggtccagtga   1080

atgttattca gtggtttggt caatattttg ccttgttttg ttggaattat atgcttttgt   1140

gagtgtggag tgtgtgtgtg catataggtg tgtgagagag agaaggggag aggaagaaag   1200

agaggcagag agtgtcacag aaagatggct tttccacatt agaacatttt aatttaagat   1260

atttaagaac aatatattta tgcccttatt tctttagaga gaaaatacct taagtcaggt   1320

aacactgagt ttgtgggacc ttaataaaat tggcatactc ttcataatgg tacctatctg   1380

gaatagtaaa aaatgagaac caccctgtgt tcatcttatg acatatgtga aacttctaat   1440

ctattatcaa atggactaat tatcatgttc tctatgttag acaagtatct agatgattta   1500

caccctttag tgattatttt gtcaactata caactacagt tactaactgt gatcaggatt   1560

ttaattaaaa tataattgct aagagtagca gaattttgat ttattttatt tgaatggaag   1620

tttattaaca ctcatccaca gatacactta tgtaattaag tttctgatga tgaaccagca   1680

caatagacag ccactactgc tcattcttgc ttcatttcct ttttctattt              1730


<210>  2315
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  2315

Met Gly Glu Asn Glu Ala Ser Leu Pro Asn Thr Ser Leu Gln Gly Lys 
1               5                   10                  15


Lys Met Ala Tyr Gln Lys Val His Ala Asp Gln Arg Ala Pro Gly His 
            20                  25                  30


Ser Gln Tyr Leu Asp Asn Asp Asp Leu Gln Ala Thr Ala Leu Asp Leu 
        35                  40                  45


Glu Trp Asp Met Glu Lys Glu Leu Glu Glu Ser Gly Phe Asp Gln Phe 
    50                  55                  60


Gln Leu Asp Gly Ala Glu Asn Gln Asn Leu Gly His Ser Glu Thr Ile 
65                  70                  75                  80


Asp Leu Asn Leu Asp Ser Ile Gln Pro Ala Thr Ser Pro Lys Gly Arg 
                85                  90                  95


Phe Gln Arg Leu Gln Glu Glu Ser Asp Tyr Ile Thr His Tyr Thr Arg 
            100                 105                 110


Ser Ala Pro Lys Ser Asn Arg Cys Asn Phe Cys His Val Leu Lys Ile 
        115                 120                 125


Leu Cys Thr Ala Thr Ile Leu Phe Ile Phe Gly Ile Leu Ile Gly Tyr 
    130                 135                 140


Tyr Val His Thr Asn Cys Pro Ser Asp Ala Pro Ser Ser Gly Thr Val 
145                 150                 155                 160


Asp Pro Gln Leu Tyr Gln Glu Ile Leu Lys Thr Ile Gln Ala Glu Asp 
                165                 170                 175


Ile Lys Lys Ser Phe Arg Asn Leu Val Gln Leu Tyr Lys Asn Glu Asp 
            180                 185                 190


Asp Met Glu Ile Ser Lys Lys Ile Lys Thr Gln Trp Thr Ser Leu Gly 
        195                 200                 205


Leu Glu Asp Val Gln Phe Val Asn Tyr Ser Val Leu Leu Asp Leu Pro 
    210                 215                 220


Gly Pro Ser Pro Ser Thr Val Thr Leu Ser Ser Ser Gly Gln Cys Phe 
225                 230                 235                 240


His Pro Asn Gly Gln Pro Cys Ser Glu Glu Ala Arg Lys Asp Ser Ser 
                245                 250                 255


Gln Asp Leu Leu Tyr Ser Tyr Ala Ala Tyr Ser Ala Lys Gly Thr Leu 
            260                 265                 270


Lys Ala Glu Val Ile Asp Val Ser Tyr Gly Met Ala Asp Asp Leu Lys 
        275                 280                 285


Arg Ile Arg Lys Ile Lys Asn Val Thr Asn Gln Ile Ala Leu Leu Lys 
    290                 295                 300


Leu Gly Lys Leu Pro Leu Leu Tyr Lys Val Gly Pro Val Asn Val Ile 
305                 310                 315                 320


Gln Trp Phe Gly Gln Tyr Phe Ala Leu Phe Cys Trp Asn Tyr Met Leu 
                325                 330                 335


Leu 



<210>  2316
<211>  4953
<212>  DNA
<213>  Homo sapiens

<400>  2316
ttattcacag aagaaagcag gtagtatact gttacaatac tacagtagaa agtcagaagg     60

tcacaaagct tgcagggtaa gtgacacaac ttgaaactgc ttggccctct ttaaaaagaa    120

ataataaaat gggagagaat gaagcaagtt tacctaacac gtctttgcaa ggtaaaaaga    180

tggcctatca gaaggtccat gcagatcaaa gagctccagg acactcacag tacttagaca    240

atgatgacct tcaagccact gcccttgact tagagtggga catggagaag gaactagagg    300

agtctggttt tgaccaattc cagctagacg gtgctgagaa tcagaaccta gggcattcag    360

agactataga cctcaatctt gattccattc aaccagcaac ttcacccaaa ggaaggttcc    420

agagacttca agaagaatct gactacatta cccattatac acgatctgca ccaaagagca    480

atcgctgcaa cttttgccac gtcttaaaaa tactttgcac agccaccatt ttatttattt    540

ttgggatttt gataggttat tatgtacata caaattgccc ttcagatgct ccatcttcag    600

gaacagttga tcctcagtta tatcaagaga ttctcaagac aatccaggca gaagatatta    660

agaagtcttt cagaaatttg gtacaactat ataaaaatga agatgacatg gaaatttcaa    720

agaagattaa gactcagtgg acctctttgg gcctagaaga tgtacagttt gtaaattact    780

ctgtgctgct tgatctgcca ggcccttctc ccagcactgt gactctgagc agcagtggtc    840

aatgctttca tcctaatggc cagccttgca gtgaagaagc cagaaaagat agcagccaag    900

acctgctcta ttcatatgca gcctattctg ccaaaggaac tctcaaggct gaagtcatcg    960

atgtgagtta tggaatggca gatgatttaa aaaggattag gaaaataaaa aacgtaacaa   1020

atcagatcgc actcctgaaa ttaggaaaat tgccactgct ttataagctt tcctcattgg   1080

aaaaggctgg atttggaggt gttcttctgt atatcgatcc ttgtgatttg ccaaagactg   1140

tgaatcctag ccatgatacc ttcatggtgt cactgaatcc aggaggagac ccttctacgc   1200

ctggttaccc aagtgtcgat gaaagtttta gacaaagccg atcaaacctc acctctctat   1260

tagtgcagcc catctctgca cccctcgttg caaaactgat ctcttcgcca aaagctagaa   1320

ccaaaaatga agcgtgtagc tctctagagc ttccaaataa tgaaataaga gtcgtcagca   1380

tgcaagttca gacagtcaca aaattgaaaa cagttactaa tgttgttgga tttgtaatgg   1440

gcttgacatc tccagaccgg tatatcatag ttggcagcca tcatcacact gcacacagtt   1500

ataatggaca agaatgggcc agtagtactg caataatcac agcgtttatc cgtgccttga   1560

tgtcaaaagt taagagaggg tggagaccag accgaactat tgttttctgt tcttggggag   1620

gaacagcttt tggcaatatt ggctcatatg aatggggaga ggatttcaag aaggttcttc   1680

agaaaaatgt tgtggcttat attagcctcc acagtcccat aagggggaac tctagtctgt   1740

atcctgtagc atcaccatct cttcagcaac tggtagtaga gaaaaataat ttcaactgta   1800

ccagaagagc ccagtgccca gaaaccaata tcagttctat acagatacaa ggtgatgctg   1860

attatttcat caaccatctt ggagttccca tcgtgcagtt tgcttacgag gacatcaaaa   1920

cattagaggg tccaagtttt ctctccgagg cccgtttttc tacacgagca acaaaaattg   1980

aagaaatgga tccctctttc aaccttcatg aaaccattac taagctctca ggagaagtga   2040

ttttgcaaat tgccaacgaa cctgttctgc cctttaatgc acttgatata gctttagaag   2100

ttcaaaacaa ccttaaaggt gatcaaccca acactcatca actgttagcc atggcgttac   2160

gcctgcggga gagtgctgaa ctttttcagt ctgatgagat gcgacctgct aatgatccca   2220

aggagagagc acccatccgc atccggatgc tgaatgacat tctccaagac atggagaaaa   2280

gctttctggt aaagcaggca ccaccaggtt tttatagaaa catcctctac caccttgatg   2340

aaaagacaag ccggttttca atacttatag aggcttggga acactgcaaa ccccttgcat   2400

caaatgagac ccttcaagaa gccctgtcag aggtgttgaa cagcattaat tcagctcagg   2460

tttacttcaa agcaggactt gatgtgttca agagtgtctt ggatgggaag aattgagaaa   2520

actctgagca tttttaaaag tttgtttaca attccacaag caaaagctct aatttaacca   2580

gattttctga cattgaaggc ttattttccc caatggcttt ttgacaagta taaagctatt   2640

attacattgt attttttaaa tgtaaatata gaaagaacat tttgcacatt taatattttt   2700

cttatatcta catttctgaa tatgtaaagc aagttattga aataggactt aagaattacc   2760

tattaaaaag aaatctgata tataaaaata tgtactattt taaggaaaaa tttccaagaa   2820

gttctggact atctttgttc ctatggggag ggcatatagg aacacagttt attctctctg   2880

atagagctat taatgactta gtttctgtaa aagaaatgga gagttgatat ggttcagatt   2940

aacttcacta ttaagtgttc aatatgaaga attcaagtat tctgactgag tgattggttg   3000

acctaaacca ctttgaatgt ttctatttta tgaaatgaag tttctcttct taacacaact   3060

agatgtagta atacactggt tatgaaattg tattttttta agtattaatg aaaaaagagc   3120

cataagcatt ccaggagaaa atctcaaggg agctacatag agcaatttaa atgcaaattt   3180

ttttcctaac aacttacaag gtgactagct ttgaaacccc taatttgcct cagttgattt   3240

tctaagaatt tcaggagtga tgtatgtctt aagagggaga aaaaaatatt tcttattact   3300

ttttctcttg tttctgttgg aaacactgaa gcagggactc taaaatgaaa gcatctcaca   3360

ttggttttct ttcttgtatc ttttctgaaa ctccttgctg taaggcagct ttctcagagt   3420

actatatatt ttcaacagta aagtagcaga gtttctcttt gaaacccaaa atgtcttcta   3480

aagaatcaaa tttctatttc tgcctctgac aaaaagaact tactatgaaa gaaatagttg   3540

ttttatcaat aaaagcccct taatattatg aagaaacttt tcatattttt tcttctttat   3600

ccttaattgt gactaagatg gaaatctaga aaatattcat gcttctaagt ttctgcagtg   3660

ttactgtaag agagtgtctc gtctacactt cagttcttct ctcatgtgga aaactaagct   3720

ttttatattg acattgccat tgaatagctc tagcaactat tattattccc ccaaacccta   3780

aaattctacc tattaggtgt caggttaaag ttctaattta tctttagaaa tttatgtgaa   3840

aaatggtttt cctatactgg ataaagcaat tccccttagg aaacatagcc tcagagtatt   3900

tcatataaat tttctctatc taattcaaac atatctcccc atgatacacc gccagagtga   3960

cattgcagac agtctgtgta tgtttaaatt ttcacttttt atggatgagc ataaacctag   4020

tcttagttta aaggcaaact aaagttgagg ggaaataatt aatcaatact gattaattga   4080

tttataaggt tcaacactgt ctaccctaaa taatttttat atgctcaagg caaagcaggg   4140

aatagaggca attagctaga taattcaagc agaaatccat tttcatcgaa attgcctgtg   4200

tgcacatatt tttagatgaa aaatgaaact accttacaat attatttttt taaccaatgt   4260

atttgtttgc aaacatttgc catgttgaag agtgtgtata ggaaaggtct agaaataaat   4320

aggcttgtgc atacctaggc attcatgctc tttcttcctc ttcagagatc atcagaaaag   4380

aggtgggaat acacaagcag gtgcatgtaa gcccaaaagc tagaaagcct tatatttaac   4440

caaaggttga tgtgttcatt ccagttattc acttacagat gaaactaaaa caaataaagg   4500

caagctatta tcagtttggt agttcattat tttagaacaa atttctaaat taatttattc   4560

ccataaccta caatagcact gagaacagaa aacatgtttc ttcttcattt tgtttaaaga   4620

ttgcgtacct aggtaagtca cactgtatag ataaaaacct tcttctgtat tcctcacctc   4680

taaattatat gttatttgct atttgaaaac tgtagttaac tatggttttt tattagtcta   4740

ttaaaagata cgtggagata ttaaattata cctaaagcag acgtccaaca aattctgtac   4800

atgctgcttt acatctttgc aacaaacctc ttaactagca gcattatttc tatagtgtga   4860

ttacctgagg gtgcctccaa atgtatatca tttcactccc ctcccctccc cacccccaat   4920

agattcaaat aaataaaatc ctgagcaaat taa                                4953


<210>  2317
<211>  795
<212>  PRT
<213>  Homo sapiens

<400>  2317

Met Gly Glu Asn Glu Ala Ser Leu Pro Asn Thr Ser Leu Gln Gly Lys 
1               5                   10                  15


Lys Met Ala Tyr Gln Lys Val His Ala Asp Gln Arg Ala Pro Gly His 
            20                  25                  30


Ser Gln Tyr Leu Asp Asn Asp Asp Leu Gln Ala Thr Ala Leu Asp Leu 
        35                  40                  45


Glu Trp Asp Met Glu Lys Glu Leu Glu Glu Ser Gly Phe Asp Gln Phe 
    50                  55                  60


Gln Leu Asp Gly Ala Glu Asn Gln Asn Leu Gly His Ser Glu Thr Ile 
65                  70                  75                  80


Asp Leu Asn Leu Asp Ser Ile Gln Pro Ala Thr Ser Pro Lys Gly Arg 
                85                  90                  95


Phe Gln Arg Leu Gln Glu Glu Ser Asp Tyr Ile Thr His Tyr Thr Arg 
            100                 105                 110


Ser Ala Pro Lys Ser Asn Arg Cys Asn Phe Cys His Val Leu Lys Ile 
        115                 120                 125


Leu Cys Thr Ala Thr Ile Leu Phe Ile Phe Gly Ile Leu Ile Gly Tyr 
    130                 135                 140


Tyr Val His Thr Asn Cys Pro Ser Asp Ala Pro Ser Ser Gly Thr Val 
145                 150                 155                 160


Asp Pro Gln Leu Tyr Gln Glu Ile Leu Lys Thr Ile Gln Ala Glu Asp 
                165                 170                 175


Ile Lys Lys Ser Phe Arg Asn Leu Val Gln Leu Tyr Lys Asn Glu Asp 
            180                 185                 190


Asp Met Glu Ile Ser Lys Lys Ile Lys Thr Gln Trp Thr Ser Leu Gly 
        195                 200                 205


Leu Glu Asp Val Gln Phe Val Asn Tyr Ser Val Leu Leu Asp Leu Pro 
    210                 215                 220


Gly Pro Ser Pro Ser Thr Val Thr Leu Ser Ser Ser Gly Gln Cys Phe 
225                 230                 235                 240


His Pro Asn Gly Gln Pro Cys Ser Glu Glu Ala Arg Lys Asp Ser Ser 
                245                 250                 255


Gln Asp Leu Leu Tyr Ser Tyr Ala Ala Tyr Ser Ala Lys Gly Thr Leu 
            260                 265                 270


Lys Ala Glu Val Ile Asp Val Ser Tyr Gly Met Ala Asp Asp Leu Lys 
        275                 280                 285


Arg Ile Arg Lys Ile Lys Asn Val Thr Asn Gln Ile Ala Leu Leu Lys 
    290                 295                 300


Leu Gly Lys Leu Pro Leu Leu Tyr Lys Leu Ser Ser Leu Glu Lys Ala 
305                 310                 315                 320


Gly Phe Gly Gly Val Leu Leu Tyr Ile Asp Pro Cys Asp Leu Pro Lys 
                325                 330                 335


Thr Val Asn Pro Ser His Asp Thr Phe Met Val Ser Leu Asn Pro Gly 
            340                 345                 350


Gly Asp Pro Ser Thr Pro Gly Tyr Pro Ser Val Asp Glu Ser Phe Arg 
        355                 360                 365


Gln Ser Arg Ser Asn Leu Thr Ser Leu Leu Val Gln Pro Ile Ser Ala 
    370                 375                 380


Pro Leu Val Ala Lys Leu Ile Ser Ser Pro Lys Ala Arg Thr Lys Asn 
385                 390                 395                 400


Glu Ala Cys Ser Ser Leu Glu Leu Pro Asn Asn Glu Ile Arg Val Val 
                405                 410                 415


Ser Met Gln Val Gln Thr Val Thr Lys Leu Lys Thr Val Thr Asn Val 
            420                 425                 430


Val Gly Phe Val Met Gly Leu Thr Ser Pro Asp Arg Tyr Ile Ile Val 
        435                 440                 445


Gly Ser His His His Thr Ala His Ser Tyr Asn Gly Gln Glu Trp Ala 
    450                 455                 460


Ser Ser Thr Ala Ile Ile Thr Ala Phe Ile Arg Ala Leu Met Ser Lys 
465                 470                 475                 480


Val Lys Arg Gly Trp Arg Pro Asp Arg Thr Ile Val Phe Cys Ser Trp 
                485                 490                 495


Gly Gly Thr Ala Phe Gly Asn Ile Gly Ser Tyr Glu Trp Gly Glu Asp 
            500                 505                 510


Phe Lys Lys Val Leu Gln Lys Asn Val Val Ala Tyr Ile Ser Leu His 
        515                 520                 525


Ser Pro Ile Arg Gly Asn Ser Ser Leu Tyr Pro Val Ala Ser Pro Ser 
    530                 535                 540


Leu Gln Gln Leu Val Val Glu Lys Asn Asn Phe Asn Cys Thr Arg Arg 
545                 550                 555                 560


Ala Gln Cys Pro Glu Thr Asn Ile Ser Ser Ile Gln Ile Gln Gly Asp 
                565                 570                 575


Ala Asp Tyr Phe Ile Asn His Leu Gly Val Pro Ile Val Gln Phe Ala 
            580                 585                 590


Tyr Glu Asp Ile Lys Thr Leu Glu Gly Pro Ser Phe Leu Ser Glu Ala 
        595                 600                 605


Arg Phe Ser Thr Arg Ala Thr Lys Ile Glu Glu Met Asp Pro Ser Phe 
    610                 615                 620


Asn Leu His Glu Thr Ile Thr Lys Leu Ser Gly Glu Val Ile Leu Gln 
625                 630                 635                 640


Ile Ala Asn Glu Pro Val Leu Pro Phe Asn Ala Leu Asp Ile Ala Leu 
                645                 650                 655


Glu Val Gln Asn Asn Leu Lys Gly Asp Gln Pro Asn Thr His Gln Leu 
            660                 665                 670


Leu Ala Met Ala Leu Arg Leu Arg Glu Ser Ala Glu Leu Phe Gln Ser 
        675                 680                 685


Asp Glu Met Arg Pro Ala Asn Asp Pro Lys Glu Arg Ala Pro Ile Arg 
    690                 695                 700


Ile Arg Met Leu Asn Asp Ile Leu Gln Asp Met Glu Lys Ser Phe Leu 
705                 710                 715                 720


Val Lys Gln Ala Pro Pro Gly Phe Tyr Arg Asn Ile Leu Tyr His Leu 
                725                 730                 735


Asp Glu Lys Thr Ser Arg Phe Ser Ile Leu Ile Glu Ala Trp Glu His 
            740                 745                 750


Cys Lys Pro Leu Ala Ser Asn Glu Thr Leu Gln Glu Ala Leu Ser Glu 
        755                 760                 765


Val Leu Asn Ser Ile Asn Ser Ala Gln Val Tyr Phe Lys Ala Gly Leu 
    770                 775                 780


Asp Val Phe Lys Ser Val Leu Asp Gly Lys Asn 
785                 790                 795


<210>  2318
<211>  408
<212>  DNA
<213>  Homo sapiens

<400>  2318
cctatgacag acaaggcaag ctctactctc agaagcaaaa attatatatc taggagtcag     60

agtatgaatc aagaagaatg gacttctgct tcttatctac ctaatgccag ataatgatga    120

cagcaatgca ttttctacat tcatatcctc aatcatatgt ttttgaatgc ttactggaaa    180

accggtttaa aagaaaggtg actagttatt ggtcttgctc tgacagccgt ggaaaccatt    240

tgctgatgaa agcacaagca acaacaacaa aaaagatgaa taaactggat ttcaacaaaa    300

acacatttgt gcttcagaga acataatcaa gaaagtgaaa aggcaaccca ccaatgggag    360

aacacagttt caaaacatat atctaataaa atatttgagt ccagatta                 408


<210>  2319
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  2319

Met Met Thr Ala Met His Phe Leu His Ser Tyr Pro Gln Ser Tyr Val 
1               5                   10                  15


Phe Glu Cys Leu Leu Glu Asn Arg Phe Lys Arg Lys Val Thr Ser Tyr 
            20                  25                  30


Trp Ser Cys Ser Asp Ser Arg Gly Asn His Leu Leu Met Lys Ala Gln 
        35                  40                  45


Ala Thr Thr Thr Lys Lys Met Asn Lys Leu Asp Phe Asn Lys Asn Thr 
    50                  55                  60


Phe Val Leu Gln Arg Thr 
65                  70


<210>  2320
<211>  1574
<212>  DNA
<213>  Homo sapiens

<400>  2320
actttttacc tcagggtcat tagaaagcca ccacagatct aggcatctaa gcaggaatag     60

gagaggaaag gcaactgtag ccacattaat cacttttatc aggaagataa atgcttttcc    120

cgaatctttc aacaggcttt cattttacat tgggcatatt tttgtcatat agccttccct    180

agctgcaagg gaggcttttc aaacttcttt atggaattca gcaagaaagt aaagaggata    240

aaatgaagca cactggatga atggtgtggc ttgatgaaat taagaaattt ggtacaacta    300

tataaaaatg aagatgacat ggaaatttca aagaagatta agactcagtg gacctctttg    360

ggcctagaag atgtacagtt tgtaaattac tctgtgctgc ttgatctgcc aggcccttct    420

cccagcactg tgactctgag cagcagtggt caatgctttc atcctaatgg ccagccttgc    480

agtgaagaag ccagaaaaga tagcagccaa gacctgctct attcatatgc agcctattct    540

gccaaaggaa ctctcaaggc tgaagtcatc gatgtgagtt atggaatggc agatgattta    600

aaaaggatta ggaaaataaa aaacgtaaca aatcagatcg cactcctgaa attaggaaaa    660

ttgccactgc tttataagct ttcctcattg gaaaaggctg gatttggagg tgttcttctg    720

tatatcgatc cttgtgattt gccaaagact gtgaatccta gccatgatac cttcatggtg    780

tcactgaatc caggaggaga cccttctacg cctggttacc caagtgtcga aataagagtc    840

gtcagcatgc aagttcagac agtcacaaaa ttgaaaacag ttactaatgt tgttggattt    900

gtaatgggct tgacatctcc agaccggtat atcatagttg gcagccatca tcacactgca    960

cacagttata atggacaaga atgggccagt agtactgcaa taatcacagc gtttatccgt   1020

gccttgatgt caaaagttaa gagagggtgg agaccagacc gaactattgt tttctgttct   1080

tggggaggaa cagcttttgg caatattggc tcatatgaat ggggagagga tttcaagaag   1140

gttcttcaga aaaatgttgt ggcttatatt agcctccaca gtcccataag ggggaactct   1200

agtctgtatc ctgtagcatc accatctctt cagcaactgg tagtagagaa aaataatttc   1260

aactgtacca gaagagccca gtgcccagaa accaatatca gttctataca gatacaaggt   1320

gatgctgatt atttcatcaa ccatcttgga gttcccatcg tgcagtttgc ttacgaggac   1380

atcaaaacat tagagggtcc aagttttctc tccgaggccc gtttttctac acgagcaaca   1440

aaaattgaag aaatggatcc ctctttcaac cttcatgaaa ccattactaa gtgaagaaca   1500

cacatgcttt catagtcttg gaatgtgtgg tatgtactct atgattgctg aaataaagtg   1560

cttttgaaaa tcct                                                     1574


<210>  2321
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  2321

Met Lys Leu Arg Asn Leu Val Gln Leu Tyr Lys Asn Glu Asp Asp Met 
1               5                   10                  15


Glu Ile Ser Lys Lys Ile Lys Thr Gln Trp Thr Ser Leu Gly Leu Glu 
            20                  25                  30


Asp Val Gln Phe Val Asn Tyr Ser Val Leu Leu Asp Leu Pro Gly Pro 
        35                  40                  45


Ser Pro Ser Thr Val Thr Leu Ser Ser Ser Gly Gln Cys Phe His Pro 
    50                  55                  60


Asn Gly Gln Pro Cys Ser Glu Glu Ala Arg Lys Asp Ser Ser Gln Asp 
65                  70                  75                  80


Leu Leu Tyr Ser Tyr Ala Ala Tyr Ser Ala Lys Gly Thr Leu Lys Ala 
                85                  90                  95


Glu Val Ile Asp Val Ser Tyr Gly Met Ala Asp Asp Leu Lys Arg Ile 
            100                 105                 110


Arg Lys Ile Lys Asn Val Thr Asn Gln Ile Ala Leu Leu Lys Leu Gly 
        115                 120                 125


Lys Leu Pro Leu Leu Tyr Lys Leu Ser Ser Leu Glu Lys Ala Gly Phe 
    130                 135                 140


Gly Gly Val Leu Leu Tyr Ile Asp Pro Cys Asp Leu Pro Lys Thr Val 
145                 150                 155                 160


Asn Pro Ser His Asp Thr Phe Met Val Ser Leu Asn Pro Gly Gly Asp 
                165                 170                 175


Pro Ser Thr Pro Gly Tyr Pro Ser Val Glu Ile Arg Val Val Ser Met 
            180                 185                 190


Gln Val Gln Thr Val Thr Lys Leu Lys Thr Val Thr Asn Val Val Gly 
        195                 200                 205


Phe Val Met Gly Leu Thr Ser Pro Asp Arg Tyr Ile Ile Val Gly Ser 
    210                 215                 220


His His His Thr Ala His Ser Tyr Asn Gly Gln Glu Trp Ala Ser Ser 
225                 230                 235                 240


Thr Ala Ile Ile Thr Ala Phe Ile Arg Ala Leu Met Ser Lys Val Lys 
                245                 250                 255


Arg Gly Trp Arg Pro Asp Arg Thr Ile Val Phe Cys Ser Trp Gly Gly 
            260                 265                 270


Thr Ala Phe Gly Asn Ile Gly Ser Tyr Glu Trp Gly Glu Asp Phe Lys 
        275                 280                 285


Lys Val Leu Gln Lys Asn Val Val Ala Tyr Ile Ser Leu His Ser Pro 
    290                 295                 300


Ile Arg Gly Asn Ser Ser Leu Tyr Pro Val Ala Ser Pro Ser Leu Gln 
305                 310                 315                 320


Gln Leu Val Val Glu Lys Asn Asn Phe Asn Cys Thr Arg Arg Ala Gln 
                325                 330                 335


Cys Pro Glu Thr Asn Ile Ser Ser Ile Gln Ile Gln Gly Asp Ala Asp 
            340                 345                 350


Tyr Phe Ile Asn His Leu Gly Val Pro Ile Val Gln Phe Ala Tyr Glu 
        355                 360                 365


Asp Ile Lys Thr Leu Glu Gly Pro Ser Phe Leu Ser Glu Ala Arg Phe 
    370                 375                 380


Ser Thr Arg Ala Thr Lys Ile Glu Glu Met Asp Pro Ser Phe Asn Leu 
385                 390                 395                 400


His Glu Thr Ile Thr Lys 
                405


<210>  2322
<211>  907
<212>  DNA
<213>  Homo sapiens

<400>  2322
acttggtgaa attcctcagg gattttgaga catcaaagca atctctctag ttctggaaag     60

actgaatttg cagcatctgc tgaaatgagg aataatcaat gttcaccagc ggaaattgaa    120

aagcaaagag atggggaaga ttccaaggat ccactcaagt tcctggtgtt tttgtgaatg    180

ttctgtgttt aagacatgct tttgtttagg agaagacatg agctgagcca actgggataa    240

agaagaggtt gaaaatgcgt atggcttaga cagagtaaag agttttagat aaaatatcgg    300

ggtaactttt agagtcttgg cttaaggcca aagcttctga atcaaggaaa gagtgacagt    360

tgccttcctc tatttttatt aatatacagg tgtgttacca ttattacctg ccagaaagag    420

cataatatta atccaatcaa attatatgag tcctacagta gaaatattgc agacatttaa    480

tattatattg aagtttaatt aatggtaaga catttcaagg tggtaatagt tatatgcagc    540

tctttggcta aaagtcaaag tgtgatatat acagaataga aacgatgctg gactgccaga    600

aaatctgcct ctccctccca ctcccccaag atctattagg aacgagcatt tactgttatt    660

atttcaaata tttatgcaaa gtaattttaa atgatttaaa cattccatat atcaatcaaa    720

gttaataata agttagattc tgaaacattt gtgccattaa caacagtcag aaagataaca    780

ttatttcatt ggtattaaat gaggcaatca acagtttgat ggaaaaaaaa aaaaaactaa    840

gtgtattttt taaaattaca cttttacata gagttagaaa actagtccat agaaaggaaa    900

ctgttga                                                              907


<210>  2323
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  2323

Met Arg Asn Asn Gln Cys Ser Pro Ala Glu Ile Glu Lys Gln Arg Asp 
1               5                   10                  15


Gly Glu Asp Ser Lys Asp Pro Leu Lys Phe Leu Val Phe Leu 
            20                  25                  30


<210>  2324
<211>  938
<212>  DNA
<213>  Homo sapiens

<400>  2324
agcagattac ccaggccttg cacctggatc aatgggctgc cctaatgaag gatatcaaaa     60

atgaaggggc agctaaagaa aaataaaaga cacctcagaa agtagcctgc ctctttgaca    120

agggacatgc cttcagagga acataacaga aacctctgag aattgtcaac aataaaaaga    180

ctgagcaaca agggaaactg gtaggaagcc aaaggtttta agaggtgaga gtggagaaat    240

gctgtgcttt tattgatcct ctccaaagga acacctttaa aaaagcatga tataaattgg    300

cactaatcct cataagagaa gaatgtcagc caagccagtg aaggaatttt ggagttcgct    360

ttgaagactt atgcactctc cagctggtca cagacactac actcacccat tttgtaaata    420

cacttttttt tgttttgttt tttaagcttc tcacttcagt atctaccaga caggcttgtg    480

caaggagtga actagtattg tatctgttaa tttctttgca ggcaaaaatc aagttaccag    540

gaaaatattt tttaaaaacc acgaacagtc taagagcact gaacattttg aatcatttgc    600

cttttctcaa cactggattt taagcaagga acaagactat tccagttcta aatgctttaa    660

tgaacaaggg gtattgggtt ttagcatcaa catgatctat cctcactctg aagctttaac    720

ttgagtagct gctgtgcttt gtaaagcttc aatccaattc atttgataac tacaattacc    780

aaatctgggc attgctgact acacagttca aaaaaacagc atggagggaa gacctgctga    840

gaaccttaga atctatcgat aagctcttga aatggtttaa agtaataaac cacttcaatt    900

gaaagggcaa taaaatgttt ttcgtgtata tatgtaca                            938


<210>  2325
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  2325

Arg Asn Phe Gly Val Arg Phe Glu Asp Leu Cys Thr Leu Gln Leu Val 
1               5                   10                  15


Thr Asp Thr Thr Leu Thr His Phe Val Asn Thr Leu Phe Phe Val Leu 
            20                  25                  30


Phe Phe Lys Leu Leu Thr Ser Val Ser Thr Arg Gln Ala Cys Ala Arg 
        35                  40                  45


Ser Glu Leu Val Leu Tyr Leu Leu Ile Ser Leu Gln Ala Lys Ile Lys 
    50                  55                  60


Leu Pro Gly Lys Tyr Phe Leu Lys Thr Thr Asn Ser Leu Arg Ala Leu 
65                  70                  75                  80


Asn Ile Leu Asn His Leu Pro Phe Leu Asn Thr Gly Phe 
                85                  90


<210>  2326
<211>  602
<212>  DNA
<213>  Homo sapiens

<400>  2326
ccctaatgaa ggatatcaaa aatgaagggg cagctaaaga aaaataaaag acacctcaga     60

aagtagcctg cctctttgac aagggacatg ccttcagagg aacataacag aaacctctga    120

gaattgtcaa caataaaaag actgagcaac aagggaaact ggtaggaagc caaaggtttt    180

aagaggcaaa aatcaagtta ccaggaaaat attttttaaa aaccacgaac agtctaagag    240

cactgaacat tttgaatcat ttgccttttc tcaacactgg attttaagca aggaacaaga    300

ctattccagt tctaaatgct ttaatgaaca aggggtattg ggttttagca tcaacatgat    360

ctatcctcac tctgaagctt taacttgagt agctgctgtg ctttgtaaag cttcaatcca    420

attcatttga taactacaat taccaaatct gggcattgct gactacacag ttcaaaaaaa    480

cagcatggag ggaagacctg ctgagaacct tagaatctat cgataagctc ttgaaatggt    540

ttaaagtaat aaaccacttc aattgaaagg gcaataaaat gtttttcgtg tatatatgta    600

ca                                                                   602


<210>  2327
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  2327

Glu Ala Lys Ile Lys Leu Pro Gly Lys Tyr Phe Leu Lys Thr Thr Asn 
1               5                   10                  15


Ser Leu Arg Ala Leu Asn Ile Leu Asn His Leu Pro Phe Leu Asn Thr 
            20                  25                  30


Gly Phe 



<210>  2328
<211>  6699
<212>  DNA
<213>  Homo sapiens

<400>  2328
gcagtgccgt agtagcgggc cacggagata gacagctttg gagctgctga actccgagca     60

cagggtgaag accccggcgc taccaaccac agcctggcag cctggtctcc gcggcaccca    120

ctggggctgc atccccctcc cccgagaggg ctgcgcaggc gggaagacgc ccagaggcca    180

gcttcggtcc cccttctgtc tctcggttcc tctttcctcc caagtaaggg aataaaccgc    240

gaagaaggag cgccccgggc caccgcgcaa ccaagtgttg cctggtgagg aagagccagg    300

acttctgaat ttaccttgaa tacagacagg aggatgttgc ctaaggaata gcagagatct    360

tgtctcatct tctgagaggt gcctgctgct gctgtataca cttgagtgct cccagaagtc    420

tcctgaaagg cttacatcgc aaacctgcaa tgagccaggc cctgggctgg gcctccactt    480

cagcctagtg aacaaaactc catcactgcc ctttagccac tcacataaag tttaaaaatg    540

ggtgaagaac ggtgggtctc cctcactcca gaagaatttg accaactcca gaaatattca    600

gaatattcct ccaagaagat aaaagatgcc ttgactgaat ttaatgaggg tgggagcctc    660

aaacaatatg acccacatga gccgattagc tatgatgtct tcaagctgtt catgagggcg    720

tacctggagg tggaccttcc ccagccactg agcactcacc tcttcctggc cttcagccag    780

aagcccagac acgagacctc tgaccacccg acggagggag ccagcaacag tgaggccaac    840

agcgcagata ctaatataca gaatgcagat aatgccacca aagcagacga ggcctgtgcc    900

cctgatactg aatcaaatat ggctgagaag caagcaccag ctgaagacca agtggctgcg    960

acccccctgg aaccccccgt ccctcggtct tcaagctcgg aatccccagt ggtatacctg   1020

aaggatgttg tgtgctacct gtccctgctg gagacgggga ggcctcagga taagctggag   1080

ttcatgtttc gcctctatga ttcagatgag aacggtctcc tggaccaagc ggagatggat   1140

tgcattgtca accaaatgct gcatattgcc cagtacctgg agtgggatcc cacagagctg   1200

aggcctatat tgaaggagat gctgcaaggg atggactacg accgggacgg ctttgtgtct   1260

ctacaggaat gggtccatgg agggatgacc accatcccat tgctggtcct cctggggatg   1320

gatgactctg gctccaaggg ggatgggcgg cacgcctgga ccatgaagca cttcaagaaa   1380

ccaacctact gcaacttctg ccatatcatg ctcatgggcg tccgcaagca aggcctgtgc   1440

tgcacttact gtaaatacac tgtccacgaa cgctgtgtgt ccagaaacat tcctggttgt   1500

gtcaaaacgt actcaaaagc caaaaggagt ggtgaggtga tgcagcacgc atgggtggaa   1560

gggaactcct ccgtcaagtg tgaccggtgc cacaaaagta tcaagtgcta ccagagtgtc   1620

accgcgcggc actgcgtgtg gtgccggatg acgtttcacc gcaaatgtga attatcaacg   1680

ttgtgtgacg gtggggaact cagagaccac atcttactgc ccacctccat atgccccatc   1740

acccgggaca ggccaggtga gaagtctgat ggctgcgtgt ccgccaaggg cgaacttgtc   1800

atgcagtata agatcatccc caccccgggt acccaccccc tgctggtctt ggtgaacccc   1860

aagagtggag ggagacaagg agaaagaatt cttcggaaat tccactatct gctcaacccc   1920

aaacaagttt tcaacctgga caatgggggg cctactccag ggttgaactt tttccgtgat   1980

actccagact tccgtgtttt ggcctgtggt ggagatggga cagttggctg gattttggat   2040

tgcattgata aggccaactt tgcaaagcat ccaccagtgg ctgtcctgcc tcttggaaca   2100

ggaaatgacc ttgcccgttg tctccgctgg ggaggaggtt atgaaggggg cagcttgaca   2160

aaaatcctga aagacattga gcagagcccc ttggtgatgc tggaccgctg gcatctggaa   2220

gtcatcccca gagaggaagt ggaaaacggg gaccaggtcc catacagcat catgaacaac   2280

tatttctcca ttggtgtgga cgcttccatt gcacacagat tccatgtgat gagagagaaa   2340

catcctgaaa aattcaacag caggatgaag aacaagctgt ggtactttga atttggcacc   2400

tcggagactt ttgcagcgac ctgcaagaaa ctccacgacc acattgagtt ggagtgtgat   2460

ggggttgggg tggacctgag caacatcttc ctggaaggca ttgccattct caacattccc   2520

agcatgtacg gaggcaccaa tctctgggga gaaaacaaga agaaccgggc tgtgatccgg   2580

gaaagcagga agggtgtcac tgaccccaaa gaactgaaat tctgcgttca agacctcagt   2640

gaccagctcc ttgaagtggt ggggctagaa ggagccatgg agatggggca gatctacacc   2700

ggcctgaaga gtgcaggcag gaggctggcc cagtgcgcct ctgtcaccat caggacaaac   2760

aagctgctgc caatgcaagt ggatggagaa ccctggatgc agccatgttg cacgattaaa   2820

attactcaca agaaccaagc gcccatgatg atggggcctc cccagaagag cagcttcttc   2880

tcgttgagaa ggaagagccg ttcaaaagac taaacagtgt gccaaacacc agctaaacca   2940

agagagaaag caagaaacta taatgcacac tcacacacaa tttatgtgca cactcacaca   3000

tgcacacaca cacacacata cacactcttc tctaaccagt ggaagcaaag ccacccttcg   3060

ggaagaaaac gtcaccttgc catacattct gtttcaacag tgggtacacc cctaacagag   3120

ccagtgccaa caaaacattt tgaatggact tagggcccat gaggttgtgg ctggcttagg   3180

cagcaacctc cacattccca caggccttga gcagaatttt ctgagactga agggaaatcc   3240

ccctttcttt ctaccagccc tgcaagtttc ctcatggacg ctcgcgagga gcaggctgca   3300

ggtttcctgc ctatggtgag atcagatgtg gccaagggaa ggagctctgg ttccagagaa   3360

tttgcacaaa gttccctctg tacagagaca aaacggcctc cggctctcag agcataatcc   3420

ttggcagggc tcagcaggcg cacgttggtt tcttggtcgt cctttgagtg acaacttctc   3480

cgtgaacctg ctgaagaggc agaaaggctg tggaaagctg tatttccatt cttgggtttc   3540

tgcgccgtcg gtgggcactt gttattttcc aggaaccttc tcctggtgtc tacatgtttg   3600

cttagaggcg gctccaagag cccccagagc tgcctgcata gcacacctta gatgtggtat   3660

ttattttctt agttctgtga acacctggga gggagagcgg agaaactggg atttattttt   3720

caaattggtg tcataatatt gtgtaaaaag ggaaggaaaa aaaaaaccac ccccagcttc   3780

tttctttttc aagccaaagc gtgtttcctg tttgagttcc aagccctggt ggcagactat   3840

tcctgaaggc agaaaagatg ggaaggaagg aactttgctg gggaaaccag gagacggttc   3900

cctcctgctt ctttgcactc accactccca gagtatgacc tgaaggacct tctgatggtc   3960

ttaacgtgtg tgcgcgcgtg tgtgtgtgtg tgtgcgtgta tatatatata tttagcctat   4020

atatttatat atatatatat ataaatattt atttactgat ggacttttcc tcattggaaa   4080

aaaaaaacat aggtagtatg agacagaaag tggtaaggaa aaagaaggtt ctcactcccc   4140

cactccaccg tttcattgtc aggacgcatc tccctgtggt gatcacaagg gttaagggga   4200

atgaaagtag ctccctatta tgaacgaaga gaccgagaac tcctattctg gatcctcaaa   4260

acaagcatga aagacctgct gggctggatt tactctccca tttgtcagat aagaaaattg   4320

agtctcagaa aagttcagag acttttccat ggtgtcttgg ctaatgcagc ttgagagtag   4380

gtgccgttac aaagatattt aatggagaaa agaacccaca catctcagag tagggtcatt   4440

tctggtcact gaaaagtgag tccacttgga tccaggttgc cagggaggaa caaacgtaca   4500

gcacatgcgt ggatgggata tccccacaca agaaaacgag cgcctcatgc tgcttcccag   4560

aggttctctc tgacctgaat ggaaaagaag ttggtctgag atcgaaggta ctaaacagat   4620

catcagactg aactctccac atgtcacctc atcatggtca tcatagtctc ttagtttgga   4680

aacaaccttg gctgcaggga tgacctcagt ggagagtcac aagaaggact gaggcgtctt   4740

ctgcaagata ctgccagcca ggacagaggg gtctcagcag agctcagtgg gcttcattca   4800

gcaagtgcca gcattaccat cctttcccaa gggcaaggcc atgcagagct tcattgggcc   4860

tccatccctc tctgagattt atcagtggaa acttggaccc acttgatatc gttccactga   4920

gctgcctcta atcttgcatt ggacaggagc tttggacaaa gaagggaata ttaagattgt   4980

gtgtacaaat ggcacttaac tgtgaaggac cacctaggag caagatcttg gaccattctg   5040

ctcaacctaa cagtgcagaa tgctaagtaa ggggaaaacc aggccacctg aagaatatct   5100

ttaatgatgg tattcttggt gatgggacca acaagctcca gaattactac aggtactatc   5160

ttggaagcca cttgtttctg aaactgaggc aggttcaggt ttggggtcac tgattctaag   5220

acatttacag aagttcgtgc atgtgtttca gccatgatcc ccaagattga ggctattgag   5280

acatggcact atcaacaggt gaaattgatt ctcagagact cacaggtctc atgaaggggc   5340

agtgcagaaa atggccctta cctgctgcac cctagtgcac aggacttgca atgttgcttg   5400

agagacatat cccaagtcct tcttagaggc atggagtata acaacttcag tggaattgca   5460

cttccagttt ggtaacctta gtaaatcttg tgttgttgtt taatcgtgcc ttgcaaatca   5520

tcctttaaac actatgactg tggtttcttg tggtggagtc cctcatcata gtgaccctca   5580

tagcaacctc tgaggttagc agagaaggta ttattatctc gatctcaatg aggagaacaa   5640

ggcttaatga ggtttagtga cttctcaaag ccacatggtt agtcagggga gaacctaatc   5700

ccttatttct tatcttattc tgattctggc catgctacaa acatgttctc acctgccccc   5760

catgcttcta ccccaacagc aataaaaact gtaaagcagg aactctctag tacattgtgt   5820

tgtccctaaa ctgatgggct aggaattgtg tctcattatg gcttagtctt tgtgggtttt   5880

ccccagtgag ttgagagtgg agatagacct agtaggatga ttatattcag gtcagagacc   5940

agctcctctc aagagagttc tttccacaga tggaaaagat acgttaaaat tgccaaataa   6000

attaggaaat acttggcaga acctggaaga gcctccagac tggcgttaca taacatgcat   6060

atacattata catatgcaca ttatataagg tgacatagta cttaatgtgc tgtatatatt   6120

atgtaaatta catatttgtg agtaatcatg ataaatatag agacccacta atcacttttt   6180

tacacatact cagtgacaga ttaggaagtt actttgccag agagtcttaa aacttactct   6240

cttctgctgc tttggttcca actcctgcca aaaataattg catcaacttt tcccatctct   6300

agccccctct tctcttggcc aaaactctca gttacctcct gtcccagcta gtctgtgcct   6360

tccgtgcaac actaccacaa ttgggatcca taaaaataga atcatgggga tgggaaggat   6420

ctagatgctc agatccccta tatgtcaggc ctacacctca acactcccag gcaggtgcat   6480

gtctaatgct aatattaaaa gagcgggagt tgggggaagg aggaagagtc taccaacctt   6540

ccaaggaagg aaacttcaca gtcttccttg gccgccagct ccgggctcta acagtaatca   6600

atcaggaaat tatttcaaat gtccagtctg agtccccaca gcatatctga aaccataatt   6660

tcctaaaatg tgtctcccaa aacactagca tccatcaaa                          6699


<210>  2329
<211>  791
<212>  PRT
<213>  Homo sapiens

<400>  2329

Met Gly Glu Glu Arg Trp Val Ser Leu Thr Pro Glu Glu Phe Asp Gln 
1               5                   10                  15


Leu Gln Lys Tyr Ser Glu Tyr Ser Ser Lys Lys Ile Lys Asp Ala Leu 
            20                  25                  30


Thr Glu Phe Asn Glu Gly Gly Ser Leu Lys Gln Tyr Asp Pro His Glu 
        35                  40                  45


Pro Ile Ser Tyr Asp Val Phe Lys Leu Phe Met Arg Ala Tyr Leu Glu 
    50                  55                  60


Val Asp Leu Pro Gln Pro Leu Ser Thr His Leu Phe Leu Ala Phe Ser 
65                  70                  75                  80


Gln Lys Pro Arg His Glu Thr Ser Asp His Pro Thr Glu Gly Ala Ser 
                85                  90                  95


Asn Ser Glu Ala Asn Ser Ala Asp Thr Asn Ile Gln Asn Ala Asp Asn 
            100                 105                 110


Ala Thr Lys Ala Asp Glu Ala Cys Ala Pro Asp Thr Glu Ser Asn Met 
        115                 120                 125


Ala Glu Lys Gln Ala Pro Ala Glu Asp Gln Val Ala Ala Thr Pro Leu 
    130                 135                 140


Glu Pro Pro Val Pro Arg Ser Ser Ser Ser Glu Ser Pro Val Val Tyr 
145                 150                 155                 160


Leu Lys Asp Val Val Cys Tyr Leu Ser Leu Leu Glu Thr Gly Arg Pro 
                165                 170                 175


Gln Asp Lys Leu Glu Phe Met Phe Arg Leu Tyr Asp Ser Asp Glu Asn 
            180                 185                 190


Gly Leu Leu Asp Gln Ala Glu Met Asp Cys Ile Val Asn Gln Met Leu 
        195                 200                 205


His Ile Ala Gln Tyr Leu Glu Trp Asp Pro Thr Glu Leu Arg Pro Ile 
    210                 215                 220


Leu Lys Glu Met Leu Gln Gly Met Asp Tyr Asp Arg Asp Gly Phe Val 
225                 230                 235                 240


Ser Leu Gln Glu Trp Val His Gly Gly Met Thr Thr Ile Pro Leu Leu 
                245                 250                 255


Val Leu Leu Gly Met Asp Asp Ser Gly Ser Lys Gly Asp Gly Arg His 
            260                 265                 270


Ala Trp Thr Met Lys His Phe Lys Lys Pro Thr Tyr Cys Asn Phe Cys 
        275                 280                 285


His Ile Met Leu Met Gly Val Arg Lys Gln Gly Leu Cys Cys Thr Tyr 
    290                 295                 300


Cys Lys Tyr Thr Val His Glu Arg Cys Val Ser Arg Asn Ile Pro Gly 
305                 310                 315                 320


Cys Val Lys Thr Tyr Ser Lys Ala Lys Arg Ser Gly Glu Val Met Gln 
                325                 330                 335


His Ala Trp Val Glu Gly Asn Ser Ser Val Lys Cys Asp Arg Cys His 
            340                 345                 350


Lys Ser Ile Lys Cys Tyr Gln Ser Val Thr Ala Arg His Cys Val Trp 
        355                 360                 365


Cys Arg Met Thr Phe His Arg Lys Cys Glu Leu Ser Thr Leu Cys Asp 
    370                 375                 380


Gly Gly Glu Leu Arg Asp His Ile Leu Leu Pro Thr Ser Ile Cys Pro 
385                 390                 395                 400


Ile Thr Arg Asp Arg Pro Gly Glu Lys Ser Asp Gly Cys Val Ser Ala 
                405                 410                 415


Lys Gly Glu Leu Val Met Gln Tyr Lys Ile Ile Pro Thr Pro Gly Thr 
            420                 425                 430


His Pro Leu Leu Val Leu Val Asn Pro Lys Ser Gly Gly Arg Gln Gly 
        435                 440                 445


Glu Arg Ile Leu Arg Lys Phe His Tyr Leu Leu Asn Pro Lys Gln Val 
    450                 455                 460


Phe Asn Leu Asp Asn Gly Gly Pro Thr Pro Gly Leu Asn Phe Phe Arg 
465                 470                 475                 480


Asp Thr Pro Asp Phe Arg Val Leu Ala Cys Gly Gly Asp Gly Thr Val 
                485                 490                 495


Gly Trp Ile Leu Asp Cys Ile Asp Lys Ala Asn Phe Ala Lys His Pro 
            500                 505                 510


Pro Val Ala Val Leu Pro Leu Gly Thr Gly Asn Asp Leu Ala Arg Cys 
        515                 520                 525


Leu Arg Trp Gly Gly Gly Tyr Glu Gly Gly Ser Leu Thr Lys Ile Leu 
    530                 535                 540


Lys Asp Ile Glu Gln Ser Pro Leu Val Met Leu Asp Arg Trp His Leu 
545                 550                 555                 560


Glu Val Ile Pro Arg Glu Glu Val Glu Asn Gly Asp Gln Val Pro Tyr 
                565                 570                 575


Ser Ile Met Asn Asn Tyr Phe Ser Ile Gly Val Asp Ala Ser Ile Ala 
            580                 585                 590


His Arg Phe His Val Met Arg Glu Lys His Pro Glu Lys Phe Asn Ser 
        595                 600                 605


Arg Met Lys Asn Lys Leu Trp Tyr Phe Glu Phe Gly Thr Ser Glu Thr 
    610                 615                 620


Phe Ala Ala Thr Cys Lys Lys Leu His Asp His Ile Glu Leu Glu Cys 
625                 630                 635                 640


Asp Gly Val Gly Val Asp Leu Ser Asn Ile Phe Leu Glu Gly Ile Ala 
                645                 650                 655


Ile Leu Asn Ile Pro Ser Met Tyr Gly Gly Thr Asn Leu Trp Gly Glu 
            660                 665                 670


Asn Lys Lys Asn Arg Ala Val Ile Arg Glu Ser Arg Lys Gly Val Thr 
        675                 680                 685


Asp Pro Lys Glu Leu Lys Phe Cys Val Gln Asp Leu Ser Asp Gln Leu 
    690                 695                 700


Leu Glu Val Val Gly Leu Glu Gly Ala Met Glu Met Gly Gln Ile Tyr 
705                 710                 715                 720


Thr Gly Leu Lys Ser Ala Gly Arg Arg Leu Ala Gln Cys Ala Ser Val 
                725                 730                 735


Thr Ile Arg Thr Asn Lys Leu Leu Pro Met Gln Val Asp Gly Glu Pro 
            740                 745                 750


Trp Met Gln Pro Cys Cys Thr Ile Lys Ile Thr His Lys Asn Gln Ala 
        755                 760                 765


Pro Met Met Met Gly Pro Pro Gln Lys Ser Ser Phe Phe Ser Leu Arg 
    770                 775                 780


Arg Lys Ser Arg Ser Lys Asp 
785                 790


<210>  2330
<211>  6624
<212>  DNA
<213>  Homo sapiens

<400>  2330
gcagtgccgt agtagcgggc cacggagata gacagctttg gagctgctga actccgagca     60

cagggtgaag accccggcgc taccaaccac agcctggcag cctggtctcc gcggcaccca    120

ctggggctgc atccccctcc cccgagaggg ctgcgcaggc gggaagacgc ccagaggcca    180

gcttcggtcc cccttctgtc tctcggttcc tctttcctcc caagtaaggg aataaaccgc    240

gaagaaggag cgccccgggc caccgcgcaa ccaagtgttg cctggtgagg aagagccagg    300

acttctgaat ttaccttgaa tacagacagg aggatgttgc ctaaggaata gcagagatct    360

tgtctcatct tctgagaggt gcctgctgct gctgtataca cttgagtgct cccagaagtc    420

tcctgaaagg cttacatcgc aaacctgcaa tgagccaggc cctgggctgg gcctccactt    480

cagcctagtg aacaaaactc catcactgcc ctttagccac tcacataaag tttaaaaatg    540

ggtgaagaac ggtgggtctc cctcactcca gaagaatttg accaactcca gaaatattca    600

gaatattcct ccaagaagat aaaagatgcc ttgactgaat ttaatgaggg tgggagcctc    660

aaacaatatg acccacatga gccgattagc tatgatgtct tcaagctgtt catgagggcg    720

tacctggagg tggaccttcc ccagccactg agcactcacc tcttcctggc cttcagccag    780

aagcccagac acgagacctc tgaccacccg acggagggag ccagcaacag tgaggccaac    840

agcgcagata ctaatataca gaatgcagat aatgccacca aagcagacga ggcctgtgcc    900

cctgatactg aatcaaatat ggctgagaag caagcaccag ctgaagacca agtggctgcg    960

acccccctgg aaccccccgt ccctcggtct tcaagctcgg aatccccagt ggtatacctg   1020

aaggatgttg tgtgctacct gtccctgctg gagacgggga ggcctcagga taagctggag   1080

ttcatgtttc gcctctatga ttcagatgag aacggtctcc tggaccaagc ggagatggat   1140

tgcattgtca accaaatgct gcatattgcc cagtacctgg agtgggatcc cacagagctg   1200

aggcctatat tgaaggagat gctgcaaggg atggactacg accgggacgg ctttgtgtct   1260

ctacaggaat gggtccatgg agggatgacc accatcccat tgctggtcct cctggggatg   1320

gatgactctg gctccaaggg ggatgggcgg cacgcctgga ccatgaagca cttcaagaaa   1380

ccaacctact gcaacttctg ccatatcatg ctcatgggcg tccgcaagca aggcctgtgc   1440

tgcacttact gtaaatacac tgtccacgaa cgctgtgtgt ccagaaacat tcctggttgt   1500

gtcaaaacgt actcaaaagc caaaaggagt ggtgaggtga tgcagcacgc atgggtggaa   1560

gggaactcct ccgtcaagtg tgaccggtgc cacaaaagta tcaagtgcta ccagagtgtc   1620

accgcgcggc actgcgtgtg gtgccggatg acgtttcacc gcaaatgtga attatcaacg   1680

ttgtgtgacg gtggggaact cagagaccac atcttactgc ccacctccat atgccccatc   1740

acccgggaca ggccaggtga gaagtctgat ggctgcgtgt ccgccaaggg cgaacttgtc   1800

atgcagtata agatcatccc caccccgggt acccaccccc tgctggtctt ggtgaacccc   1860

aagagtggag ggagacaagg agaaaggttg aactttttcc gtgatactcc agacttccgt   1920

gttttggcct gtggtggaga tgggacagtt ggctggattt tggattgcat tgataaggcc   1980

aactttgcaa agcatccacc agtggctgtc ctgcctcttg gaacaggaaa tgaccttgcc   2040

cgttgtctcc gctggggagg aggttatgaa gggggcagct tgacaaaaat cctgaaagac   2100

attgagcaga gccccttggt gatgctggac cgctggcatc tggaagtcat ccccagagag   2160

gaagtggaaa acggggacca ggtcccatac agcatcatga acaactattt ctccattggt   2220

gtggacgctt ccattgcaca cagattccat gtgatgagag agaaacatcc tgaaaaattc   2280

aacagcagga tgaagaacaa gctgtggtac tttgaatttg gcacctcgga gacttttgca   2340

gcgacctgca agaaactcca cgaccacatt gagttggagt gtgatggggt tggggtggac   2400

ctgagcaaca tcttcctgga aggcattgcc attctcaaca ttcccagcat gtacggaggc   2460

accaatctct ggggagaaaa caagaagaac cgggctgtga tccgggaaag caggaagggt   2520

gtcactgacc ccaaagaact gaaattctgc gttcaagacc tcagtgacca gctccttgaa   2580

gtggtggggc tagaaggagc catggagatg gggcagatct acaccggcct gaagagtgca   2640

ggcaggaggc tggcccagtg cgcctctgtc accatcagga caaacaagct gctgccaatg   2700

caagtggatg gagaaccctg gatgcagcca tgttgcacga ttaaaattac tcacaagaac   2760

caagcgccca tgatgatggg gcctccccag aagagcagct tcttctcgtt gagaaggaag   2820

agccgttcaa aagactaaac agtgtgccaa acaccagcta aaccaagaga gaaagcaaga   2880

aactataatg cacactcaca cacaatttat gtgcacactc acacatgcac acacacacac   2940

acatacacac tcttctctaa ccagtggaag caaagccacc cttcgggaag aaaacgtcac   3000

cttgccatac attctgtttc aacagtgggt acacccctaa cagagccagt gccaacaaaa   3060

cattttgaat ggacttaggg cccatgaggt tgtggctggc ttaggcagca acctccacat   3120

tcccacaggc cttgagcaga attttctgag actgaaggga aatccccctt tctttctacc   3180

agccctgcaa gtttcctcat ggacgctcgc gaggagcagg ctgcaggttt cctgcctatg   3240

gtgagatcag atgtggccaa gggaaggagc tctggttcca gagaatttgc acaaagttcc   3300

ctctgtacag agacaaaacg gcctccggct ctcagagcat aatccttggc agggctcagc   3360

aggcgcacgt tggtttcttg gtcgtccttt gagtgacaac ttctccgtga acctgctgaa   3420

gaggcagaaa ggctgtggaa agctgtattt ccattcttgg gtttctgcgc cgtcggtggg   3480

cacttgttat tttccaggaa ccttctcctg gtgtctacat gtttgcttag aggcggctcc   3540

aagagccccc agagctgcct gcatagcaca ccttagatgt ggtatttatt ttcttagttc   3600

tgtgaacacc tgggagggag agcggagaaa ctgggattta tttttcaaat tggtgtcata   3660

atattgtgta aaaagggaag gaaaaaaaaa accaccccca gcttctttct ttttcaagcc   3720

aaagcgtgtt tcctgtttga gttccaagcc ctggtggcag actattcctg aaggcagaaa   3780

agatgggaag gaaggaactt tgctggggaa accaggagac ggttccctcc tgcttctttg   3840

cactcaccac tcccagagta tgacctgaag gaccttctga tggtcttaac gtgtgtgcgc   3900

gcgtgtgtgt gtgtgtgtgc gtgtatatat atatatttag cctatatatt tatatatata   3960

tatatataaa tatttattta ctgatggact tttcctcatt ggaaaaaaaa aacataggta   4020

gtatgagaca gaaagtggta aggaaaaaga aggttctcac tcccccactc caccgtttca   4080

ttgtcaggac gcatctccct gtggtgatca caagggttaa ggggaatgaa agtagctccc   4140

tattatgaac gaagagaccg agaactccta ttctggatcc tcaaaacaag catgaaagac   4200

ctgctgggct ggatttactc tcccatttgt cagataagaa aattgagtct cagaaaagtt   4260

cagagacttt tccatggtgt cttggctaat gcagcttgag agtaggtgcc gttacaaaga   4320

tatttaatgg agaaaagaac ccacacatct cagagtaggg tcatttctgg tcactgaaaa   4380

gtgagtccac ttggatccag gttgccaggg aggaacaaac gtacagcaca tgcgtggatg   4440

ggatatcccc acacaagaaa acgagcgcct catgctgctt cccagaggtt ctctctgacc   4500

tgaatggaaa agaagttggt ctgagatcga aggtactaaa cagatcatca gactgaactc   4560

tccacatgtc acctcatcat ggtcatcata gtctcttagt ttggaaacaa ccttggctgc   4620

agggatgacc tcagtggaga gtcacaagaa ggactgaggc gtcttctgca agatactgcc   4680

agccaggaca gaggggtctc agcagagctc agtgggcttc attcagcaag tgccagcatt   4740

accatccttt cccaagggca aggccatgca gagcttcatt gggcctccat ccctctctga   4800

gatttatcag tggaaacttg gacccacttg atatcgttcc actgagctgc ctctaatctt   4860

gcattggaca ggagctttgg acaaagaagg gaatattaag attgtgtgta caaatggcac   4920

ttaactgtga aggaccacct aggagcaaga tcttggacca ttctgctcaa cctaacagtg   4980

cagaatgcta agtaagggga aaaccaggcc acctgaagaa tatctttaat gatggtattc   5040

ttggtgatgg gaccaacaag ctccagaatt actacaggta ctatcttgga agccacttgt   5100

ttctgaaact gaggcaggtt caggtttggg gtcactgatt ctaagacatt tacagaagtt   5160

cgtgcatgtg tttcagccat gatccccaag attgaggcta ttgagacatg gcactatcaa   5220

caggtgaaat tgattctcag agactcacag gtctcatgaa ggggcagtgc agaaaatggc   5280

ccttacctgc tgcaccctag tgcacaggac ttgcaatgtt gcttgagaga catatcccaa   5340

gtccttctta gaggcatgga gtataacaac ttcagtggaa ttgcacttcc agtttggtaa   5400

ccttagtaaa tcttgtgttg ttgtttaatc gtgccttgca aatcatcctt taaacactat   5460

gactgtggtt tcttgtggtg gagtccctca tcatagtgac cctcatagca acctctgagg   5520

ttagcagaga aggtattatt atctcgatct caatgaggag aacaaggctt aatgaggttt   5580

agtgacttct caaagccaca tggttagtca ggggagaacc taatccctta tttcttatct   5640

tattctgatt ctggccatgc tacaaacatg ttctcacctg ccccccatgc ttctacccca   5700

acagcaataa aaactgtaaa gcaggaactc tctagtacat tgtgttgtcc ctaaactgat   5760

gggctaggaa ttgtgtctca ttatggctta gtctttgtgg gttttcccca gtgagttgag   5820

agtggagata gacctagtag gatgattata ttcaggtcag agaccagctc ctctcaagag   5880

agttctttcc acagatggaa aagatacgtt aaaattgcca aataaattag gaaatacttg   5940

gcagaacctg gaagagcctc cagactggcg ttacataaca tgcatataca ttatacatat   6000

gcacattata taaggtgaca tagtacttaa tgtgctgtat atattatgta aattacatat   6060

ttgtgagtaa tcatgataaa tatagagacc cactaatcac ttttttacac atactcagtg   6120

acagattagg aagttacttt gccagagagt cttaaaactt actctcttct gctgctttgg   6180

ttccaactcc tgccaaaaat aattgcatca acttttccca tctctagccc cctcttctct   6240

tggccaaaac tctcagttac ctcctgtccc agctagtctg tgccttccgt gcaacactac   6300

cacaattggg atccataaaa atagaatcat ggggatggga aggatctaga tgctcagatc   6360

ccctatatgt caggcctaca cctcaacact cccaggcagg tgcatgtcta atgctaatat   6420

taaaagagcg ggagttgggg gaaggaggaa gagtctacca accttccaag gaaggaaact   6480

tcacagtctt ccttggccgc cagctccggg ctctaacagt aatcaatcag gaaattattt   6540

caaatgtcca gtctgagtcc ccacagcata tctgaaacca taatttccta aaatgtgtct   6600

cccaaaacac tagcatccat caaa                                          6624


<210>  2331
<211>  766
<212>  PRT
<213>  Homo sapiens

<400>  2331

Met Gly Glu Glu Arg Trp Val Ser Leu Thr Pro Glu Glu Phe Asp Gln 
1               5                   10                  15


Leu Gln Lys Tyr Ser Glu Tyr Ser Ser Lys Lys Ile Lys Asp Ala Leu 
            20                  25                  30


Thr Glu Phe Asn Glu Gly Gly Ser Leu Lys Gln Tyr Asp Pro His Glu 
        35                  40                  45


Pro Ile Ser Tyr Asp Val Phe Lys Leu Phe Met Arg Ala Tyr Leu Glu 
    50                  55                  60


Val Asp Leu Pro Gln Pro Leu Ser Thr His Leu Phe Leu Ala Phe Ser 
65                  70                  75                  80


Gln Lys Pro Arg His Glu Thr Ser Asp His Pro Thr Glu Gly Ala Ser 
                85                  90                  95


Asn Ser Glu Ala Asn Ser Ala Asp Thr Asn Ile Gln Asn Ala Asp Asn 
            100                 105                 110


Ala Thr Lys Ala Asp Glu Ala Cys Ala Pro Asp Thr Glu Ser Asn Met 
        115                 120                 125


Ala Glu Lys Gln Ala Pro Ala Glu Asp Gln Val Ala Ala Thr Pro Leu 
    130                 135                 140


Glu Pro Pro Val Pro Arg Ser Ser Ser Ser Glu Ser Pro Val Val Tyr 
145                 150                 155                 160


Leu Lys Asp Val Val Cys Tyr Leu Ser Leu Leu Glu Thr Gly Arg Pro 
                165                 170                 175


Gln Asp Lys Leu Glu Phe Met Phe Arg Leu Tyr Asp Ser Asp Glu Asn 
            180                 185                 190


Gly Leu Leu Asp Gln Ala Glu Met Asp Cys Ile Val Asn Gln Met Leu 
        195                 200                 205


His Ile Ala Gln Tyr Leu Glu Trp Asp Pro Thr Glu Leu Arg Pro Ile 
    210                 215                 220


Leu Lys Glu Met Leu Gln Gly Met Asp Tyr Asp Arg Asp Gly Phe Val 
225                 230                 235                 240


Ser Leu Gln Glu Trp Val His Gly Gly Met Thr Thr Ile Pro Leu Leu 
                245                 250                 255


Val Leu Leu Gly Met Asp Asp Ser Gly Ser Lys Gly Asp Gly Arg His 
            260                 265                 270


Ala Trp Thr Met Lys His Phe Lys Lys Pro Thr Tyr Cys Asn Phe Cys 
        275                 280                 285


His Ile Met Leu Met Gly Val Arg Lys Gln Gly Leu Cys Cys Thr Tyr 
    290                 295                 300


Cys Lys Tyr Thr Val His Glu Arg Cys Val Ser Arg Asn Ile Pro Gly 
305                 310                 315                 320


Cys Val Lys Thr Tyr Ser Lys Ala Lys Arg Ser Gly Glu Val Met Gln 
                325                 330                 335


His Ala Trp Val Glu Gly Asn Ser Ser Val Lys Cys Asp Arg Cys His 
            340                 345                 350


Lys Ser Ile Lys Cys Tyr Gln Ser Val Thr Ala Arg His Cys Val Trp 
        355                 360                 365


Cys Arg Met Thr Phe His Arg Lys Cys Glu Leu Ser Thr Leu Cys Asp 
    370                 375                 380


Gly Gly Glu Leu Arg Asp His Ile Leu Leu Pro Thr Ser Ile Cys Pro 
385                 390                 395                 400


Ile Thr Arg Asp Arg Pro Gly Glu Lys Ser Asp Gly Cys Val Ser Ala 
                405                 410                 415


Lys Gly Glu Leu Val Met Gln Tyr Lys Ile Ile Pro Thr Pro Gly Thr 
            420                 425                 430


His Pro Leu Leu Val Leu Val Asn Pro Lys Ser Gly Gly Arg Gln Gly 
        435                 440                 445


Glu Arg Leu Asn Phe Phe Arg Asp Thr Pro Asp Phe Arg Val Leu Ala 
    450                 455                 460


Cys Gly Gly Asp Gly Thr Val Gly Trp Ile Leu Asp Cys Ile Asp Lys 
465                 470                 475                 480


Ala Asn Phe Ala Lys His Pro Pro Val Ala Val Leu Pro Leu Gly Thr 
                485                 490                 495


Gly Asn Asp Leu Ala Arg Cys Leu Arg Trp Gly Gly Gly Tyr Glu Gly 
            500                 505                 510


Gly Ser Leu Thr Lys Ile Leu Lys Asp Ile Glu Gln Ser Pro Leu Val 
        515                 520                 525


Met Leu Asp Arg Trp His Leu Glu Val Ile Pro Arg Glu Glu Val Glu 
    530                 535                 540


Asn Gly Asp Gln Val Pro Tyr Ser Ile Met Asn Asn Tyr Phe Ser Ile 
545                 550                 555                 560


Gly Val Asp Ala Ser Ile Ala His Arg Phe His Val Met Arg Glu Lys 
                565                 570                 575


His Pro Glu Lys Phe Asn Ser Arg Met Lys Asn Lys Leu Trp Tyr Phe 
            580                 585                 590


Glu Phe Gly Thr Ser Glu Thr Phe Ala Ala Thr Cys Lys Lys Leu His 
        595                 600                 605


Asp His Ile Glu Leu Glu Cys Asp Gly Val Gly Val Asp Leu Ser Asn 
    610                 615                 620


Ile Phe Leu Glu Gly Ile Ala Ile Leu Asn Ile Pro Ser Met Tyr Gly 
625                 630                 635                 640


Gly Thr Asn Leu Trp Gly Glu Asn Lys Lys Asn Arg Ala Val Ile Arg 
                645                 650                 655


Glu Ser Arg Lys Gly Val Thr Asp Pro Lys Glu Leu Lys Phe Cys Val 
            660                 665                 670


Gln Asp Leu Ser Asp Gln Leu Leu Glu Val Val Gly Leu Glu Gly Ala 
        675                 680                 685


Met Glu Met Gly Gln Ile Tyr Thr Gly Leu Lys Ser Ala Gly Arg Arg 
    690                 695                 700


Leu Ala Gln Cys Ala Ser Val Thr Ile Arg Thr Asn Lys Leu Leu Pro 
705                 710                 715                 720


Met Gln Val Asp Gly Glu Pro Trp Met Gln Pro Cys Cys Thr Ile Lys 
                725                 730                 735


Ile Thr His Lys Asn Gln Ala Pro Met Met Met Gly Pro Pro Gln Lys 
            740                 745                 750


Ser Ser Phe Phe Ser Leu Arg Arg Lys Ser Arg Ser Lys Asp 
        755                 760                 765


<210>  2332
<211>  5800
<212>  DNA
<213>  Homo sapiens

<400>  2332
gcagtgccgt agtagcgggc cacggagata gacagctttg gagctgctga actccgagca     60

cagggtgaag accccggcgc taccaaccac agcctggcag cctggtctcc gcggcaccca    120

ctggggctgc atccccctcc cccgagaggg ctgcgcaggc gggaagacgc ccagaggcca    180

gcttcggtcc cccttctgtc tctcggttcc tctttcctcc caagtaaggg aataaaccgc    240

gaagaaggag cgccccgggc caccgcgcaa ccaagtgttg cctggtgagg aagagccagg    300

acttctgaat ttaccttgaa tacagacagg aggatgttgc ctaaggaata gcagagatct    360

tgtctcatct tctgagaggt gcctgctgct gctgtataca cttgagtgct cccagaagtc    420

tcctgaaagg cttacatcgc aaacctgcaa tgagccaggc cctgggctgg gcctccactt    480

cagcctagtg aacaaaactc catcactgcc ctttagccac tcacataaag tttaaaaatg    540

ggtgaagaac ggtgggtctc cctcactcca gaagaatttg accaactcca gaaatattca    600

gaatattcct ccaagaagat aaaagatgcc ttgactgaat ttaatgaggg tgggagcctc    660

aaacaatatg acccacatga gccgattagc tatgatgtct tcaagctgtt catgagggcg    720

tacctggagg tggaccttcc ccagccactg agcactcacc tcttcctggc cttcagccag    780

aagcccagac acgagacctc tgaccacccg acggagggag ccagcaacag tgaggccaac    840

agcgcagata ctaatataca gaatgcagat aatgccacca aagcagacga ggcctgtgcc    900

cctgatactg aatcaaatat ggctgagaag caagcaccag ctgaagacca agtggctgcg    960

acccccctgg aaccccccgt ccctcggtct tcaagctcgg aatccccagt ggtatacctg   1020

aaggatgttg tgtgctacct gtccctgctg gagacgggga ggcctcagga taagctggag   1080

ttcatgtttc gcctctatga ttcagatgag aacggtctcc tggaccaagc ggagatggat   1140

tgcattgtca accaaatgct gcatattgcc cagtacctgg agtgggatcc cacagagctg   1200

aggcctatat tgaaggagat gctgcaaggg atggactacg accgggacgg ctttgtgtct   1260

ctacaggaat gggtccatgg agggatgacc accatcccat tgctggtcct cctggggatg   1320

gatgactctg gctccaaggg ggatgggcgg cacgcctgga ccatgaagca cttcaagaaa   1380

ccaacctact gcaacttctg ccatatcatg ctcatgggcg tccgcaagca aggcctgtgc   1440

tgcacttact gtaaatacac tgtccacgaa cgctgtgtgt ccagaaacat tcctggttgt   1500

gtcaaaacgt actcaaaagc caaaaggagt ggtgaggtga tgcagcacgc atgggtggaa   1560

gggaactcct ccgtcaagtg tgaccggtgc cacaaaagta tcaagtgcta ccagagtgtc   1620

accgcgcggc actgcgtgtg gtgccggatg acgtttcacc gcaaatgtga attatcaacg   1680

ttgtgtgacg gtggggaact cagagaccac atcttactgc ccacctccat atgccccatc   1740

acccgggaca ggccaggtga gaagtctgat ggctgcgtgt ccgccaaggg cgaacttgtc   1800

atgcagtata agatcatccc caccccgggt acccaccccc tgctggtctt ggtgaacccc   1860

aagagtggag ggagacaagg agaaagaatt cttcggaaat tccactatct gctcaacccc   1920

aaacaagttt tcaacctgga caatgggggg cctactccag ggttgaactt tttccgtgat   1980

actccagact tccgtgtttt ggcctgtggt ggagatggga cagttggctg gattttggat   2040

tgcattgata aggccaactt tgcaaagcat ccaccagtgg ctgtcctgcc tcttggaaca   2100

ggaaatgacc ttgcccgttg tctccgctgg ggaggaggtt atgaaggggg cagcttgaca   2160

aaaatcctga aagacattga gcagagcccc ttggtgatgc tggaccgctg gcatctggaa   2220

gtcatcccca gagaggaagt ggaaaacggg gaccaggtcc catacagcat catgaacaac   2280

tatttctcca ttggtgtgga cgcttccatt gcacacagat tccatgtgat gagagagaaa   2340

catcctgaaa aattcaacag caggatgaag aacaagctgt ggtactttga atttggcacc   2400

tcggagactt ttgcagcgac ctgcaagaaa ctccacgacc acattgagtt ggagtgtgat   2460

ggggttgggg tggacctgag caacatcttc ctggaaggca ttgccattct caacattccc   2520

agcatgtacg gaggcaccaa tctctgggga gaaaacaaga agaaccgggc tgtgatccgg   2580

gaaagcagga agggtgtcac tgaccccaaa gaactgaaat tctgcgttca agacctcagt   2640

gaccagctcc ttgaagtggt ggggctagaa ggagccatgg agatggggca gatctacacc   2700

ggcctgaaga gtgcaggcag gaggctggcc cagtgcgcct ctgtcaccat caggacaaac   2760

aagctgctgc caatgcaagt ggatggagaa ccctggatgc agccatgttg cacgattaaa   2820

attactcaca agaaccaagc gcccatgatg atggggcctc cccagaagag cagcttcttc   2880

tcgttgagaa ggaagagccg ttcaaaagac taaacagtgt gccaaacacc agctaaacca   2940

agagagaaag caagaaacta taatgcacac tcacacacaa tttatgtgca cactcacaca   3000

tgcacacaca cacacacata cacactcttc tctaaccagt ggaagcaaag ccacccttcg   3060

ggaagaaaac gtcaccttgc catacattct gtttcaacag tgggtacacc cctaacagag   3120

ccagtgccaa caaaacattt tgaatggact tagggcccat gaggttgtgg ctggcttagg   3180

cagcaacctc cacattccca caggccttga gcagaatttt ctgagactga agggaaatcc   3240

ccctttcttt ctaccagccc tgcaagtttc ctcatggacg ctcgcgagga gcaggctgca   3300

ggtttcctgc ctatggtgag atcagatgtg gccaagggaa ggagctctgg ttccagagaa   3360

tttgcacaaa gttccctctg tacagagaca aaacggcctc cggctctcag agcataatcc   3420

ttggcagggc tcagcaggcg cacgttggtt tcttggtcgt cctttgagtg acaacttctc   3480

cgtgaacctg ctgaagaggc agaaaggctg tggaaagctg tatttccatt cttgggtttc   3540

tgcgccgtcg gtgggcactt gttattttcc aggaaccttc tcctggtgtc tacatgtttg   3600

cttagaggcg gctccaagag cccccagagc tgcctgcata gcacacctta gatgtggtat   3660

ttattttctt agttctgtga acacctggga gggagagcgg agaaactggg atttattttt   3720

caaattggtg tcataatatt gtgtaaaaag ggaaggaaaa aaaaaaccac ccccagcttc   3780

tttctttttc aagccaaagc gtgtttcctg tttgagttcc aagccctggt ggcagactat   3840

tcctgaaggc agaaaagatg ggaaggaagg aactttgctg gggaaaccag gagacggttc   3900

cctcctgctt ctttgcactc accactccca gagtatgacc tgaaggacct tctgatggtc   3960

ttaacgtgtg tgcgcgcgtg tgtgtgtgtg tgtgcgtgta tatatatata tttagcctat   4020

atatttatat atatatatat ataaatattt atttactgat ggacttttcc tcattggaaa   4080

aaaaaaacat aggtagtatg agacagaaag tggtaaggaa aaagaaggtt ctcactcccc   4140

cactccaccg tttcattgtc aggacgcatc tccctgtggt gatcacaagg gttaagggga   4200

atgaaagtag ctccctatta tgaacgaaga gaccgagaac tcctattctg gatcctcaaa   4260

acaagcatga aagacctgct gggctggatt tactctccca tttgtcagat aagaaaattg   4320

agtctcagaa aagttcagag acttttccat ggtgtcttgg ctaatgcagc ttgagagtag   4380

gtgccgttac aaagatattt aatggagaaa agaacccaca catctcagag tagggtcatt   4440

tctggtcact gaaaagtgag tccacttgga tccaggttgc cagggaggaa caaacgtaca   4500

gcacatgcgt ggatgggata tccccacaca agaaaacgag cgcctcatgc tgcttcccag   4560

aggttctctc tgacctgaat ggaaaagaag ttggtctgag atcgaaggta ctaaacagat   4620

catcagactg aactctccac atgtcacctc atcatggtca tcatagtctc ttagtttgga   4680

aacaaccttg gctgcaggga tgacctcagt ggagagtcac aagaaggact gaggcgtctt   4740

ctgcaagata ctgccagcca ggacagaggg gtctcagcag agctcagtgg gcttcattca   4800

gcaagtgcca gcattaccat cctttcccaa gggcaaggcc atgcagagct tcattgggcc   4860

tccatccctc tctgagattt atcagtggaa acttggaccc acttgatatc gttccactga   4920

gctgcctcta atcttgcatt ggacaggagc tttggacaaa gaagggaata ttaagattgt   4980

gtgtacaaat ggcacttaac tgtgaaggac cacctaggag caagatcttg gaccattctg   5040

ctcaacctaa cagtgcagaa tgctaagtaa ggggaaaacc aggccacctg aagaatatct   5100

ttaatgatgg tattcttggt gatgggacca acaagctcca gaattactac aggtactatc   5160

ttggaagcca cttgtttctg aaactgaggc aggttcaggt ttggggtcac tgattctaag   5220

acatttacag aagttcgtgc atgtgtttca gccatgatcc ccaagattga ggctattgag   5280

acatggcact atcaacaggt gaaattgatt ctcagagact cacaggtctc atgaaggggc   5340

agtgcagaaa atggccctta cctgctgcac cctagtgcac aggacttgca atgttgcttg   5400

agagacatat cccaagtcct tcttagaggc atggagtata acaacttcag tggaattgca   5460

cttccagttt ggtaacctta gtaaatcttg tgttgttgtt taatcgtgcc ttgcaaatca   5520

tcctttaaac actatgactg tggtttcttg tggtggagtc cctcatcata gtgaccctca   5580

tagcaacctc tgaggttagc agagaaggta ttattatctc gatctcaatg aggagaacaa   5640

ggcttaatga ggtttagtga cttctcaaag ccacatggtt agtcagggga gaacctaatc   5700

ccttatttct tatcttattc tgattctggc catgctacaa acatgttctc acctgccccc   5760

catgcttcta ccccaacagc aataaaaact gtaaagcagg                         5800


<210>  2333
<211>  791
<212>  PRT
<213>  Homo sapiens

<400>  2333

Met Gly Glu Glu Arg Trp Val Ser Leu Thr Pro Glu Glu Phe Asp Gln 
1               5                   10                  15


Leu Gln Lys Tyr Ser Glu Tyr Ser Ser Lys Lys Ile Lys Asp Ala Leu 
            20                  25                  30


Thr Glu Phe Asn Glu Gly Gly Ser Leu Lys Gln Tyr Asp Pro His Glu 
        35                  40                  45


Pro Ile Ser Tyr Asp Val Phe Lys Leu Phe Met Arg Ala Tyr Leu Glu 
    50                  55                  60


Val Asp Leu Pro Gln Pro Leu Ser Thr His Leu Phe Leu Ala Phe Ser 
65                  70                  75                  80


Gln Lys Pro Arg His Glu Thr Ser Asp His Pro Thr Glu Gly Ala Ser 
                85                  90                  95


Asn Ser Glu Ala Asn Ser Ala Asp Thr Asn Ile Gln Asn Ala Asp Asn 
            100                 105                 110


Ala Thr Lys Ala Asp Glu Ala Cys Ala Pro Asp Thr Glu Ser Asn Met 
        115                 120                 125


Ala Glu Lys Gln Ala Pro Ala Glu Asp Gln Val Ala Ala Thr Pro Leu 
    130                 135                 140


Glu Pro Pro Val Pro Arg Ser Ser Ser Ser Glu Ser Pro Val Val Tyr 
145                 150                 155                 160


Leu Lys Asp Val Val Cys Tyr Leu Ser Leu Leu Glu Thr Gly Arg Pro 
                165                 170                 175


Gln Asp Lys Leu Glu Phe Met Phe Arg Leu Tyr Asp Ser Asp Glu Asn 
            180                 185                 190


Gly Leu Leu Asp Gln Ala Glu Met Asp Cys Ile Val Asn Gln Met Leu 
        195                 200                 205


His Ile Ala Gln Tyr Leu Glu Trp Asp Pro Thr Glu Leu Arg Pro Ile 
    210                 215                 220


Leu Lys Glu Met Leu Gln Gly Met Asp Tyr Asp Arg Asp Gly Phe Val 
225                 230                 235                 240


Ser Leu Gln Glu Trp Val His Gly Gly Met Thr Thr Ile Pro Leu Leu 
                245                 250                 255


Val Leu Leu Gly Met Asp Asp Ser Gly Ser Lys Gly Asp Gly Arg His 
            260                 265                 270


Ala Trp Thr Met Lys His Phe Lys Lys Pro Thr Tyr Cys Asn Phe Cys 
        275                 280                 285


His Ile Met Leu Met Gly Val Arg Lys Gln Gly Leu Cys Cys Thr Tyr 
    290                 295                 300


Cys Lys Tyr Thr Val His Glu Arg Cys Val Ser Arg Asn Ile Pro Gly 
305                 310                 315                 320


Cys Val Lys Thr Tyr Ser Lys Ala Lys Arg Ser Gly Glu Val Met Gln 
                325                 330                 335


His Ala Trp Val Glu Gly Asn Ser Ser Val Lys Cys Asp Arg Cys His 
            340                 345                 350


Lys Ser Ile Lys Cys Tyr Gln Ser Val Thr Ala Arg His Cys Val Trp 
        355                 360                 365


Cys Arg Met Thr Phe His Arg Lys Cys Glu Leu Ser Thr Leu Cys Asp 
    370                 375                 380


Gly Gly Glu Leu Arg Asp His Ile Leu Leu Pro Thr Ser Ile Cys Pro 
385                 390                 395                 400


Ile Thr Arg Asp Arg Pro Gly Glu Lys Ser Asp Gly Cys Val Ser Ala 
                405                 410                 415


Lys Gly Glu Leu Val Met Gln Tyr Lys Ile Ile Pro Thr Pro Gly Thr 
            420                 425                 430


His Pro Leu Leu Val Leu Val Asn Pro Lys Ser Gly Gly Arg Gln Gly 
        435                 440                 445


Glu Arg Ile Leu Arg Lys Phe His Tyr Leu Leu Asn Pro Lys Gln Val 
    450                 455                 460


Phe Asn Leu Asp Asn Gly Gly Pro Thr Pro Gly Leu Asn Phe Phe Arg 
465                 470                 475                 480


Asp Thr Pro Asp Phe Arg Val Leu Ala Cys Gly Gly Asp Gly Thr Val 
                485                 490                 495


Gly Trp Ile Leu Asp Cys Ile Asp Lys Ala Asn Phe Ala Lys His Pro 
            500                 505                 510


Pro Val Ala Val Leu Pro Leu Gly Thr Gly Asn Asp Leu Ala Arg Cys 
        515                 520                 525


Leu Arg Trp Gly Gly Gly Tyr Glu Gly Gly Ser Leu Thr Lys Ile Leu 
    530                 535                 540


Lys Asp Ile Glu Gln Ser Pro Leu Val Met Leu Asp Arg Trp His Leu 
545                 550                 555                 560


Glu Val Ile Pro Arg Glu Glu Val Glu Asn Gly Asp Gln Val Pro Tyr 
                565                 570                 575


Ser Ile Met Asn Asn Tyr Phe Ser Ile Gly Val Asp Ala Ser Ile Ala 
            580                 585                 590


His Arg Phe His Val Met Arg Glu Lys His Pro Glu Lys Phe Asn Ser 
        595                 600                 605


Arg Met Lys Asn Lys Leu Trp Tyr Phe Glu Phe Gly Thr Ser Glu Thr 
    610                 615                 620


Phe Ala Ala Thr Cys Lys Lys Leu His Asp His Ile Glu Leu Glu Cys 
625                 630                 635                 640


Asp Gly Val Gly Val Asp Leu Ser Asn Ile Phe Leu Glu Gly Ile Ala 
                645                 650                 655


Ile Leu Asn Ile Pro Ser Met Tyr Gly Gly Thr Asn Leu Trp Gly Glu 
            660                 665                 670


Asn Lys Lys Asn Arg Ala Val Ile Arg Glu Ser Arg Lys Gly Val Thr 
        675                 680                 685


Asp Pro Lys Glu Leu Lys Phe Cys Val Gln Asp Leu Ser Asp Gln Leu 
    690                 695                 700


Leu Glu Val Val Gly Leu Glu Gly Ala Met Glu Met Gly Gln Ile Tyr 
705                 710                 715                 720


Thr Gly Leu Lys Ser Ala Gly Arg Arg Leu Ala Gln Cys Ala Ser Val 
                725                 730                 735


Thr Ile Arg Thr Asn Lys Leu Leu Pro Met Gln Val Asp Gly Glu Pro 
            740                 745                 750


Trp Met Gln Pro Cys Cys Thr Ile Lys Ile Thr His Lys Asn Gln Ala 
        755                 760                 765


Pro Met Met Met Gly Pro Pro Gln Lys Ser Ser Phe Phe Ser Leu Arg 
    770                 775                 780


Arg Lys Ser Arg Ser Lys Asp 
785                 790


<210>  2334
<211>  5725
<212>  DNA
<213>  Homo sapiens

<400>  2334
gcagtgccgt agtagcgggc cacggagata gacagctttg gagctgctga actccgagca     60

cagggtgaag accccggcgc taccaaccac agcctggcag cctggtctcc gcggcaccca    120

ctggggctgc atccccctcc cccgagaggg ctgcgcaggc gggaagacgc ccagaggcca    180

gcttcggtcc cccttctgtc tctcggttcc tctttcctcc caagtaaggg aataaaccgc    240

gaagaaggag cgccccgggc caccgcgcaa ccaagtgttg cctggtgagg aagagccagg    300

acttctgaat ttaccttgaa tacagacagg aggatgttgc ctaaggaata gcagagatct    360

tgtctcatct tctgagaggt gcctgctgct gctgtataca cttgagtgct cccagaagtc    420

tcctgaaagg cttacatcgc aaacctgcaa tgagccaggc cctgggctgg gcctccactt    480

cagcctagtg aacaaaactc catcactgcc ctttagccac tcacataaag tttaaaaatg    540

ggtgaagaac ggtgggtctc cctcactcca gaagaatttg accaactcca gaaatattca    600

gaatattcct ccaagaagat aaaagatgcc ttgactgaat ttaatgaggg tgggagcctc    660

aaacaatatg acccacatga gccgattagc tatgatgtct tcaagctgtt catgagggcg    720

tacctggagg tggaccttcc ccagccactg agcactcacc tcttcctggc cttcagccag    780

aagcccagac acgagacctc tgaccacccg acggagggag ccagcaacag tgaggccaac    840

agcgcagata ctaatataca gaatgcagat aatgccacca aagcagacga ggcctgtgcc    900

cctgatactg aatcaaatat ggctgagaag caagcaccag ctgaagacca agtggctgcg    960

acccccctgg aaccccccgt ccctcggtct tcaagctcgg aatccccagt ggtatacctg   1020

aaggatgttg tgtgctacct gtccctgctg gagacgggga ggcctcagga taagctggag   1080

ttcatgtttc gcctctatga ttcagatgag aacggtctcc tggaccaagc ggagatggat   1140

tgcattgtca accaaatgct gcatattgcc cagtacctgg agtgggatcc cacagagctg   1200

aggcctatat tgaaggagat gctgcaaggg atggactacg accgggacgg ctttgtgtct   1260

ctacaggaat gggtccatgg agggatgacc accatcccat tgctggtcct cctggggatg   1320

gatgactctg gctccaaggg ggatgggcgg cacgcctgga ccatgaagca cttcaagaaa   1380

ccaacctact gcaacttctg ccatatcatg ctcatgggcg tccgcaagca aggcctgtgc   1440

tgcacttact gtaaatacac tgtccacgaa cgctgtgtgt ccagaaacat tcctggttgt   1500

gtcaaaacgt actcaaaagc caaaaggagt ggtgaggtga tgcagcacgc atgggtggaa   1560

gggaactcct ccgtcaagtg tgaccggtgc cacaaaagta tcaagtgcta ccagagtgtc   1620

accgcgcggc actgcgtgtg gtgccggatg acgtttcacc gcaaatgtga attatcaacg   1680

ttgtgtgacg gtggggaact cagagaccac atcttactgc ccacctccat atgccccatc   1740

acccgggaca ggccaggtga gaagtctgat ggctgcgtgt ccgccaaggg cgaacttgtc   1800

atgcagtata agatcatccc caccccgggt acccaccccc tgctggtctt ggtgaacccc   1860

aagagtggag ggagacaagg agaaaggttg aactttttcc gtgatactcc agacttccgt   1920

gttttggcct gtggtggaga tgggacagtt ggctggattt tggattgcat tgataaggcc   1980

aactttgcaa agcatccacc agtggctgtc ctgcctcttg gaacaggaaa tgaccttgcc   2040

cgttgtctcc gctggggagg aggttatgaa gggggcagct tgacaaaaat cctgaaagac   2100

attgagcaga gccccttggt gatgctggac cgctggcatc tggaagtcat ccccagagag   2160

gaagtggaaa acggggacca ggtcccatac agcatcatga acaactattt ctccattggt   2220

gtggacgctt ccattgcaca cagattccat gtgatgagag agaaacatcc tgaaaaattc   2280

aacagcagga tgaagaacaa gctgtggtac tttgaatttg gcacctcgga gacttttgca   2340

gcgacctgca agaaactcca cgaccacatt gagttggagt gtgatggggt tggggtggac   2400

ctgagcaaca tcttcctgga aggcattgcc attctcaaca ttcccagcat gtacggaggc   2460

accaatctct ggggagaaaa caagaagaac cgggctgtga tccgggaaag caggaagggt   2520

gtcactgacc ccaaagaact gaaattctgc gttcaagacc tcagtgacca gctccttgaa   2580

gtggtggggc tagaaggagc catggagatg gggcagatct acaccggcct gaagagtgca   2640

ggcaggaggc tggcccagtg cgcctctgtc accatcagga caaacaagct gctgccaatg   2700

caagtggatg gagaaccctg gatgcagcca tgttgcacga ttaaaattac tcacaagaac   2760

caagcgccca tgatgatggg gcctccccag aagagcagct tcttctcgtt gagaaggaag   2820

agccgttcaa aagactaaac agtgtgccaa acaccagcta aaccaagaga gaaagcaaga   2880

aactataatg cacactcaca cacaatttat gtgcacactc acacatgcac acacacacac   2940

acatacacac tcttctctaa ccagtggaag caaagccacc cttcgggaag aaaacgtcac   3000

cttgccatac attctgtttc aacagtgggt acacccctaa cagagccagt gccaacaaaa   3060

cattttgaat ggacttaggg cccatgaggt tgtggctggc ttaggcagca acctccacat   3120

tcccacaggc cttgagcaga attttctgag actgaaggga aatccccctt tctttctacc   3180

agccctgcaa gtttcctcat ggacgctcgc gaggagcagg ctgcaggttt cctgcctatg   3240

gtgagatcag atgtggccaa gggaaggagc tctggttcca gagaatttgc acaaagttcc   3300

ctctgtacag agacaaaacg gcctccggct ctcagagcat aatccttggc agggctcagc   3360

aggcgcacgt tggtttcttg gtcgtccttt gagtgacaac ttctccgtga acctgctgaa   3420

gaggcagaaa ggctgtggaa agctgtattt ccattcttgg gtttctgcgc cgtcggtggg   3480

cacttgttat tttccaggaa ccttctcctg gtgtctacat gtttgcttag aggcggctcc   3540

aagagccccc agagctgcct gcatagcaca ccttagatgt ggtatttatt ttcttagttc   3600

tgtgaacacc tgggagggag agcggagaaa ctgggattta tttttcaaat tggtgtcata   3660

atattgtgta aaaagggaag gaaaaaaaaa accaccccca gcttctttct ttttcaagcc   3720

aaagcgtgtt tcctgtttga gttccaagcc ctggtggcag actattcctg aaggcagaaa   3780

agatgggaag gaaggaactt tgctggggaa accaggagac ggttccctcc tgcttctttg   3840

cactcaccac tcccagagta tgacctgaag gaccttctga tggtcttaac gtgtgtgcgc   3900

gcgtgtgtgt gtgtgtgtgc gtgtatatat atatatttag cctatatatt tatatatata   3960

tatatataaa tatttattta ctgatggact tttcctcatt ggaaaaaaaa aacataggta   4020

gtatgagaca gaaagtggta aggaaaaaga aggttctcac tcccccactc caccgtttca   4080

ttgtcaggac gcatctccct gtggtgatca caagggttaa ggggaatgaa agtagctccc   4140

tattatgaac gaagagaccg agaactccta ttctggatcc tcaaaacaag catgaaagac   4200

ctgctgggct ggatttactc tcccatttgt cagataagaa aattgagtct cagaaaagtt   4260

cagagacttt tccatggtgt cttggctaat gcagcttgag agtaggtgcc gttacaaaga   4320

tatttaatgg agaaaagaac ccacacatct cagagtaggg tcatttctgg tcactgaaaa   4380

gtgagtccac ttggatccag gttgccaggg aggaacaaac gtacagcaca tgcgtggatg   4440

ggatatcccc acacaagaaa acgagcgcct catgctgctt cccagaggtt ctctctgacc   4500

tgaatggaaa agaagttggt ctgagatcga aggtactaaa cagatcatca gactgaactc   4560

tccacatgtc acctcatcat ggtcatcata gtctcttagt ttggaaacaa ccttggctgc   4620

agggatgacc tcagtggaga gtcacaagaa ggactgaggc gtcttctgca agatactgcc   4680

agccaggaca gaggggtctc agcagagctc agtgggcttc attcagcaag tgccagcatt   4740

accatccttt cccaagggca aggccatgca gagcttcatt gggcctccat ccctctctga   4800

gatttatcag tggaaacttg gacccacttg atatcgttcc actgagctgc ctctaatctt   4860

gcattggaca ggagctttgg acaaagaagg gaatattaag attgtgtgta caaatggcac   4920

ttaactgtga aggaccacct aggagcaaga tcttggacca ttctgctcaa cctaacagtg   4980

cagaatgcta agtaagggga aaaccaggcc acctgaagaa tatctttaat gatggtattc   5040

ttggtgatgg gaccaacaag ctccagaatt actacaggta ctatcttgga agccacttgt   5100

ttctgaaact gaggcaggtt caggtttggg gtcactgatt ctaagacatt tacagaagtt   5160

cgtgcatgtg tttcagccat gatccccaag attgaggcta ttgagacatg gcactatcaa   5220

caggtgaaat tgattctcag agactcacag gtctcatgaa ggggcagtgc agaaaatggc   5280

ccttacctgc tgcaccctag tgcacaggac ttgcaatgtt gcttgagaga catatcccaa   5340

gtccttctta gaggcatgga gtataacaac ttcagtggaa ttgcacttcc agtttggtaa   5400

ccttagtaaa tcttgtgttg ttgtttaatc gtgccttgca aatcatcctt taaacactat   5460

gactgtggtt tcttgtggtg gagtccctca tcatagtgac cctcatagca acctctgagg   5520

ttagcagaga aggtattatt atctcgatct caatgaggag aacaaggctt aatgaggttt   5580

agtgacttct caaagccaca tggttagtca ggggagaacc taatccctta tttcttatct   5640

tattctgatt ctggccatgc tacaaacatg ttctcacctg ccccccatgc ttctacccca   5700

acagcaataa aaactgtaaa gcagg                                         5725


<210>  2335
<211>  766
<212>  PRT
<213>  Homo sapiens

<400>  2335

Met Gly Glu Glu Arg Trp Val Ser Leu Thr Pro Glu Glu Phe Asp Gln 
1               5                   10                  15


Leu Gln Lys Tyr Ser Glu Tyr Ser Ser Lys Lys Ile Lys Asp Ala Leu 
            20                  25                  30


Thr Glu Phe Asn Glu Gly Gly Ser Leu Lys Gln Tyr Asp Pro His Glu 
        35                  40                  45


Pro Ile Ser Tyr Asp Val Phe Lys Leu Phe Met Arg Ala Tyr Leu Glu 
    50                  55                  60


Val Asp Leu Pro Gln Pro Leu Ser Thr His Leu Phe Leu Ala Phe Ser 
65                  70                  75                  80


Gln Lys Pro Arg His Glu Thr Ser Asp His Pro Thr Glu Gly Ala Ser 
                85                  90                  95


Asn Ser Glu Ala Asn Ser Ala Asp Thr Asn Ile Gln Asn Ala Asp Asn 
            100                 105                 110


Ala Thr Lys Ala Asp Glu Ala Cys Ala Pro Asp Thr Glu Ser Asn Met 
        115                 120                 125


Ala Glu Lys Gln Ala Pro Ala Glu Asp Gln Val Ala Ala Thr Pro Leu 
    130                 135                 140


Glu Pro Pro Val Pro Arg Ser Ser Ser Ser Glu Ser Pro Val Val Tyr 
145                 150                 155                 160


Leu Lys Asp Val Val Cys Tyr Leu Ser Leu Leu Glu Thr Gly Arg Pro 
                165                 170                 175


Gln Asp Lys Leu Glu Phe Met Phe Arg Leu Tyr Asp Ser Asp Glu Asn 
            180                 185                 190


Gly Leu Leu Asp Gln Ala Glu Met Asp Cys Ile Val Asn Gln Met Leu 
        195                 200                 205


His Ile Ala Gln Tyr Leu Glu Trp Asp Pro Thr Glu Leu Arg Pro Ile 
    210                 215                 220


Leu Lys Glu Met Leu Gln Gly Met Asp Tyr Asp Arg Asp Gly Phe Val 
225                 230                 235                 240


Ser Leu Gln Glu Trp Val His Gly Gly Met Thr Thr Ile Pro Leu Leu 
                245                 250                 255


Val Leu Leu Gly Met Asp Asp Ser Gly Ser Lys Gly Asp Gly Arg His 
            260                 265                 270


Ala Trp Thr Met Lys His Phe Lys Lys Pro Thr Tyr Cys Asn Phe Cys 
        275                 280                 285


His Ile Met Leu Met Gly Val Arg Lys Gln Gly Leu Cys Cys Thr Tyr 
    290                 295                 300


Cys Lys Tyr Thr Val His Glu Arg Cys Val Ser Arg Asn Ile Pro Gly 
305                 310                 315                 320


Cys Val Lys Thr Tyr Ser Lys Ala Lys Arg Ser Gly Glu Val Met Gln 
                325                 330                 335


His Ala Trp Val Glu Gly Asn Ser Ser Val Lys Cys Asp Arg Cys His 
            340                 345                 350


Lys Ser Ile Lys Cys Tyr Gln Ser Val Thr Ala Arg His Cys Val Trp 
        355                 360                 365


Cys Arg Met Thr Phe His Arg Lys Cys Glu Leu Ser Thr Leu Cys Asp 
    370                 375                 380


Gly Gly Glu Leu Arg Asp His Ile Leu Leu Pro Thr Ser Ile Cys Pro 
385                 390                 395                 400


Ile Thr Arg Asp Arg Pro Gly Glu Lys Ser Asp Gly Cys Val Ser Ala 
                405                 410                 415


Lys Gly Glu Leu Val Met Gln Tyr Lys Ile Ile Pro Thr Pro Gly Thr 
            420                 425                 430


His Pro Leu Leu Val Leu Val Asn Pro Lys Ser Gly Gly Arg Gln Gly 
        435                 440                 445


Glu Arg Leu Asn Phe Phe Arg Asp Thr Pro Asp Phe Arg Val Leu Ala 
    450                 455                 460


Cys Gly Gly Asp Gly Thr Val Gly Trp Ile Leu Asp Cys Ile Asp Lys 
465                 470                 475                 480


Ala Asn Phe Ala Lys His Pro Pro Val Ala Val Leu Pro Leu Gly Thr 
                485                 490                 495


Gly Asn Asp Leu Ala Arg Cys Leu Arg Trp Gly Gly Gly Tyr Glu Gly 
            500                 505                 510


Gly Ser Leu Thr Lys Ile Leu Lys Asp Ile Glu Gln Ser Pro Leu Val 
        515                 520                 525


Met Leu Asp Arg Trp His Leu Glu Val Ile Pro Arg Glu Glu Val Glu 
    530                 535                 540


Asn Gly Asp Gln Val Pro Tyr Ser Ile Met Asn Asn Tyr Phe Ser Ile 
545                 550                 555                 560


Gly Val Asp Ala Ser Ile Ala His Arg Phe His Val Met Arg Glu Lys 
                565                 570                 575


His Pro Glu Lys Phe Asn Ser Arg Met Lys Asn Lys Leu Trp Tyr Phe 
            580                 585                 590


Glu Phe Gly Thr Ser Glu Thr Phe Ala Ala Thr Cys Lys Lys Leu His 
        595                 600                 605


Asp His Ile Glu Leu Glu Cys Asp Gly Val Gly Val Asp Leu Ser Asn 
    610                 615                 620


Ile Phe Leu Glu Gly Ile Ala Ile Leu Asn Ile Pro Ser Met Tyr Gly 
625                 630                 635                 640


Gly Thr Asn Leu Trp Gly Glu Asn Lys Lys Asn Arg Ala Val Ile Arg 
                645                 650                 655


Glu Ser Arg Lys Gly Val Thr Asp Pro Lys Glu Leu Lys Phe Cys Val 
            660                 665                 670


Gln Asp Leu Ser Asp Gln Leu Leu Glu Val Val Gly Leu Glu Gly Ala 
        675                 680                 685


Met Glu Met Gly Gln Ile Tyr Thr Gly Leu Lys Ser Ala Gly Arg Arg 
    690                 695                 700


Leu Ala Gln Cys Ala Ser Val Thr Ile Arg Thr Asn Lys Leu Leu Pro 
705                 710                 715                 720


Met Gln Val Asp Gly Glu Pro Trp Met Gln Pro Cys Cys Thr Ile Lys 
                725                 730                 735


Ile Thr His Lys Asn Gln Ala Pro Met Met Met Gly Pro Pro Gln Lys 
            740                 745                 750


Ser Ser Phe Phe Ser Leu Arg Arg Lys Ser Arg Ser Lys Asp 
        755                 760                 765


<210>  2336
<211>  6197
<212>  DNA
<213>  Homo sapiens

<400>  2336
gcagtgccgt agtagcgggc cacggagata gacagctttg gagctgctga actccgagca     60

cagggtgaag accccggcgc taccaaccac agcctggcag cctggtctcc gcggcaccca    120

ctggggctgc atccccctcc cccgagaggg ctgcgcaggc gggaagacgc ccagaggcca    180

gcttcggtcc cccttctgtc tctcggttcc tctttcctcc caagtaaggg aataaaccgc    240

gaagaaggag cgccccgggc caccgcgcaa ccaagtgttg cctggtgagg aagagccagg    300

acttctgaat ttaccttgaa tacagacagg aggatgttgc ctaaggaata gcagagatct    360

tgtctcatct tctgagaggt gcctgctgct gctgtataca cttgagtgct cccagaagtc    420

tcctgaaagg cttacatcgc aaacctgcaa tgagccaggc cctgggctgg gcctccactt    480

cagcctagtg aacaaaactc catcactgcc ctttagccac tcacataaag tttaaaaatg    540

ggtgaagaac ggtgggtctc cctcactcca gaagaatttg accaactcca gaaatattca    600

gaatattcct ccaagaagat aaaagatgcc ttgactgaat ttaatgaggg tgggagcctc    660

aaacaatatg acccacatga gccgattagc tatgatgtct tcaagctgtt catgagggcg    720

tacctggagg tggaccttcc ccagccactg agcactcacc tcttcctggc cttcagccag    780

aagcccagac acgagacctc tgaccacccg acggagggag ccagcaacag tgaggccaac    840

agcgcagata ctaatataca gaatgcagat aatgccacca aagcagacga ggcctgtgcc    900

cctgatactg aatcaaatat ggctgagaag caagcaccag ctgaagacca agtggctgcg    960

acccccctgg aaccccccgt ccctcggtct tcaagctcgg aatccccagt ggtatacctg   1020

aaggatgttg tgtgctacct gtccctgctg gagacgggga ggcctcagga taagctggag   1080

ttcatgtttc gcctctatga ttcagatgag aacggtctcc tggaccaagc ggagatggat   1140

tgcattgtca accaaatgct gcatattgcc cagtacctgg agtgggatcc cacagagctg   1200

aggcctatat tgaaggagat gctgcaaggg atggactacg accgggacgg ctttgtgtct   1260

ctacaggaat gggtccatgg agggatgacc accatcccat tgctggtcct cctggggatg   1320

gatgactctg gctccaaggg ggatgggcgg cacgcctgga ccatgaagca cttcaagaaa   1380

ccaacctact gcaacttctg ccatatcatg ctcatgggcg tccgcaagca aggcctgtgc   1440

tgcacttact gtaaatacac tgtccacgaa cgctgtgtgt ccagaaacat tcctggttgt   1500

gtcaaaacgt actcaaaagc caaaaggagt ggtgagtttc accgcaaatg tgaattatca   1560

acgttgtgtg acggtgggga actcagagac cacatcttac tgcccacctc catatgcccc   1620

atcacccggg acaggccagg tgagaagtct gatggctgcg tgtccgccaa gggcgaactt   1680

gtcatgcagt ataagatcat ccccaccccg ggtacccacc ccctgctggt cttggtgaac   1740

cccaagagtg gagggagaca aggagaaaga attcttcgga aattccacta tctgctcaac   1800

cccaaacaag ttttcaacct ggacaatggg gggcctactc cagggttgaa ctttttccgt   1860

gatactccag acttccgtgt tttggcctgt ggtggagatg ggacagttgg ctggattttg   1920

gattgcattg ataaggccaa ctttgcaaag catccaccag tggctgtcct gcctcttgga   1980

acaggaaatg accttgcccg ttgtctccgc tggggaggag gttatgaagg gggcagcttg   2040

acaaaaatcc tgaaagacat tgagcagagc cccttggtga tgctggaccg ctggcatctg   2100

gaagtcatcc ccagagagga agtggaaaac ggggaccagg tcccatacag catcatgaac   2160

aactatttct ccattggtgt ggacgcttcc attgcacaca gattccatgt gatgagagag   2220

aaacatcctg aaaaattcaa cagcaggatg aagaacaagc tgtggtactt tgaatttggc   2280

acctcggaga cttttgcagc gacctgcaag aaactccacg accacattga gttggagtgg   2340

tgctaagtgc ctcatggaat ctgcaaagca gccctaagtg gcaggtgtca taatcacctt   2400

tccagagaag ggggacacag gctgagagaa gtgtgatggg gttggggtgg acctgagcaa   2460

catcttcctg gaaggcattg ccattctcaa cattcccagc atgtacggag gcaccaatct   2520

ctggggagaa aacaagaaga accgggctgt gatccgggaa agcaggaagg gtgtcactga   2580

ccccaaagaa ctgaaattct gcgttcaaga cctcagtgac cagctccttg aagtggtggg   2640

gctagaagga gccatggaga tggggcagat ctacaccggc ctgaagagtg caggcaggag   2700

gctggcccag tgcgcctctg tcaccatcag gacaaacaag ctgctgccaa tgcaagtgga   2760

tggagaaccc tggatgcagc catgttgcac ggtgagtctt gccaatcttt gagatgggga   2820

tgagaagcct tatttttgag cccttttggg cactgactta atatgaaatc actgaatctc   2880

agagtcacag ggactgtgga agattatcta gtgcaacccc tcttccactt tattatccat   2940

ccactcattt acctggcaac tcttaatgaa aacctgctat atgccagaca ctgtgaagcg   3000

ccggtcacaa aattgaatga gacatagaac caacttcgag gagttcacag ttctagtcag   3060

tgaattctga gacttcatct actgtatcct ggacagcctc agcttgaatc atgtcaatgg   3120

caaggaattt actacctcaa aaggaagact gttctgctga tgaacaagtc aaattgcttc   3180

cttacgtgga agccaaatct acacacttac cttacctaga atttggtagg gtagcgcctt   3240

tgactgctgg agctcccggg agaaaattcc tcgcagagca cagacatgcc tcccagtcgg   3300

tgcacccaaa gccctgataa cctacttgaa aattccactg aatgagtcac cacgcaggtt   3360

atctattttg tttatggcac tgtcacccag aacgtagaac agtgcctggt ttgtaatagt   3420

tgcacaataa tacatgtcaa atgatgaata aaagactgaa caaatgaact aacaaaaata   3480

gactatctcc attcccagac ttaccatatc cgttagctct ccctttagca ctaggacagg   3540

agccatgcat ccttccttct tagtttgtcc tcagttagaa atgcagctag aatctcgtgg   3600

tgaagagcaa tcgtcgtcct ggttttcagg gcctctgctg ggatactaca tgcgtaatac   3660

cctcaataag attgcagcta tgcaaatttc aaaagacaaa agtggagttt ctaagcttcc   3720

tcactctagt ggagtattca gatactttga tcacctgcta ttttgagccc tccagaacat   3780

caaattgtct tctactaaag gaaggtttcc atgaacctgc tgagaaaagg tagcatcttc   3840

tataaaggtt atcaaaaaca gaaatttctc tgcaaaaatc ttacctcaat cttatgaaga   3900

ccaagaaaaa aatgaaaaca cactatatca aataatagct ttccaccttg ctggagttag   3960

gacgcataga gggaatttct actatttatc atttgatgga actgagttga gaagaatcta   4020

tccaagttcc ttttatctcc aaccccccta caaaaaaaaa ggtggaagaa atcaaaccct   4080

ctcctacctg gttcagtcct agctgaaaac tggattgcta ttcctataaa ttcaagcact   4140

ggattttgaa atagccaaat gcttctccct atgcccacac ccacccttcc tccataccac   4200

cctttagaga ttacaactca ctatgaaaaa atttgtgaac caatgatttc atagtgtgag   4260

gcccagaaat ccgtatgtaa aggtatattc gtctgctttg agtgccataa tagaatacca   4320

cagactgaca gcttaaacaa cagaaattta ttttctcaca gttctggagg ctgacaacac   4380

aagaccaagg tgccggaagg gctggtttct ggggaggcct ctcttcctaa cttccaacgg   4440

ctgccttctt gttgtatcct cacatggctt ttcctctgtg tttgtacact cttttctctt   4500

cttataagga caccagttct aagggattat ggcccccccg ccccttgtga cctcatttat   4560

ccgttattac ctccttaaag gccctaccta caaatatagt cacactgggg gttaggaatt   4620

caacatatga atttgggggg gacacaattt attccataac agaaggtaac agaaaatcat   4680

tcttaaactt gcaagggtta aaacccatgt accccttgtt gaaacatctt cttgaaggta   4740

tacaccaact aagaagtgat tcaaaattaa agccttaaga atggactatc acagcccaaa   4800

agaacttttg gtaaaaatgg aaaccagtga aattagaatg aagtttccaa aaacctgcta   4860

aatatgttta tgcaataaat gcaaatggca aaaaatcatt ctttgaaaga gaagacatat   4920

catgtaaata ttaataacct gtatcccaaa cctgagatta tattaacaaa ggccaaaaac   4980

atgcaggaga cactgctgaa ggaatagtaa agatatgtga agtttctcat tgtctctctt   5040

cactttgatg acaaaacgta taaatcagaa gataatttta ataggtagac aatcactagc   5100

gaaactaaaa atagggtgca cacctttcaa atctggaaga atttaaaata tataaaccct   5160

attaatgtag cacaggatag aaagcaaaaa ataagccaac atttaaaaat tttttgaagc   5220

aagttgaatg atgttaagac tgtatatata taatatatat ataaaagaaa aatagatgag   5280

ttaaaattcc ctattaaaag atcaatactc tcatattgag ttaaaaatga aaatccaaat   5340

atatgcttct tacaaaagat acatctaaaa tgaaaggtta tacatacgta tatataatat   5400

atatcttatt ttatccttta tcaggtataa agaaattaaa aggaagacat agtaatgtta   5460

attatgctaa ttttaggcaa actaaccttt ccatgtgcct aaagcataaa gcagaataag   5520

taaacacatt ttttatttga taaaaagtac attcaattat gagatatagt ggtcataaaa   5580

tgttagatat ttaataacag aatcaaaata tataaaaaac tatcaataca tattctgaga   5640

aaaggttgat atagaattga cagacagata ttgagaagct tgaaaatatt tgtttccatc   5700

tttgaggtta agtagcaaaa aaataaatgc ttggatgaaa taactctata actcataaag   5760

aaattaaata tcatatttgt tcaggcattc atatttatta aactagatca taaactagtt   5820

tacaaggcaa aaagctccat aaaatccagt tgcagaaatt ataaaggtca ttttctttga   5880

ccacaaagta ataaagctag aaattactaa tagaagatta agtgaataaa caaaatttag   5940

tcacttggag acttaaaaat tctcctaaac aacaagagat ttatgaggag atcaaagcca   6000

ccatggtaga ttactcaaaa aattacaaaa ataagaaggc tccagtttaa aaattataga   6060

atatagccta aactatattt ggaagtaaat taaaagcctc ataatcttcc atcatataaa   6120

aaagaagtaa aatgtaatga ataatactaa aattagaaga gcaataataa aacaatctta   6180

ggagaagcag aaggaag                                                  6197


<210>  2337
<211>  602
<212>  PRT
<213>  Homo sapiens

<400>  2337

Met Gly Glu Glu Arg Trp Val Ser Leu Thr Pro Glu Glu Phe Asp Gln 
1               5                   10                  15


Leu Gln Lys Tyr Ser Glu Tyr Ser Ser Lys Lys Ile Lys Asp Ala Leu 
            20                  25                  30


Thr Glu Phe Asn Glu Gly Gly Ser Leu Lys Gln Tyr Asp Pro His Glu 
        35                  40                  45


Pro Ile Ser Tyr Asp Val Phe Lys Leu Phe Met Arg Ala Tyr Leu Glu 
    50                  55                  60


Val Asp Leu Pro Gln Pro Leu Ser Thr His Leu Phe Leu Ala Phe Ser 
65                  70                  75                  80


Gln Lys Pro Arg His Glu Thr Ser Asp His Pro Thr Glu Gly Ala Ser 
                85                  90                  95


Asn Ser Glu Ala Asn Ser Ala Asp Thr Asn Ile Gln Asn Ala Asp Asn 
            100                 105                 110


Ala Thr Lys Ala Asp Glu Ala Cys Ala Pro Asp Thr Glu Ser Asn Met 
        115                 120                 125


Ala Glu Lys Gln Ala Pro Ala Glu Asp Gln Val Ala Ala Thr Pro Leu 
    130                 135                 140


Glu Pro Pro Val Pro Arg Ser Ser Ser Ser Glu Ser Pro Val Val Tyr 
145                 150                 155                 160


Leu Lys Asp Val Val Cys Tyr Leu Ser Leu Leu Glu Thr Gly Arg Pro 
                165                 170                 175


Gln Asp Lys Leu Glu Phe Met Phe Arg Leu Tyr Asp Ser Asp Glu Asn 
            180                 185                 190


Gly Leu Leu Asp Gln Ala Glu Met Asp Cys Ile Val Asn Gln Met Leu 
        195                 200                 205


His Ile Ala Gln Tyr Leu Glu Trp Asp Pro Thr Glu Leu Arg Pro Ile 
    210                 215                 220


Leu Lys Glu Met Leu Gln Gly Met Asp Tyr Asp Arg Asp Gly Phe Val 
225                 230                 235                 240


Ser Leu Gln Glu Trp Val His Gly Gly Met Thr Thr Ile Pro Leu Leu 
                245                 250                 255


Val Leu Leu Gly Met Asp Asp Ser Gly Ser Lys Gly Asp Gly Arg His 
            260                 265                 270


Ala Trp Thr Met Lys His Phe Lys Lys Pro Thr Tyr Cys Asn Phe Cys 
        275                 280                 285


His Ile Met Leu Met Gly Val Arg Lys Gln Gly Leu Cys Cys Thr Tyr 
    290                 295                 300


Cys Lys Tyr Thr Val His Glu Arg Cys Val Ser Arg Asn Ile Pro Gly 
305                 310                 315                 320


Cys Val Lys Thr Tyr Ser Lys Ala Lys Arg Ser Gly Glu Phe His Arg 
                325                 330                 335


Lys Cys Glu Leu Ser Thr Leu Cys Asp Gly Gly Glu Leu Arg Asp His 
            340                 345                 350


Ile Leu Leu Pro Thr Ser Ile Cys Pro Ile Thr Arg Asp Arg Pro Gly 
        355                 360                 365


Glu Lys Ser Asp Gly Cys Val Ser Ala Lys Gly Glu Leu Val Met Gln 
    370                 375                 380


Tyr Lys Ile Ile Pro Thr Pro Gly Thr His Pro Leu Leu Val Leu Val 
385                 390                 395                 400


Asn Pro Lys Ser Gly Gly Arg Gln Gly Glu Arg Ile Leu Arg Lys Phe 
                405                 410                 415


His Tyr Leu Leu Asn Pro Lys Gln Val Phe Asn Leu Asp Asn Gly Gly 
            420                 425                 430


Pro Thr Pro Gly Leu Asn Phe Phe Arg Asp Thr Pro Asp Phe Arg Val 
        435                 440                 445


Leu Ala Cys Gly Gly Asp Gly Thr Val Gly Trp Ile Leu Asp Cys Ile 
    450                 455                 460


Asp Lys Ala Asn Phe Ala Lys His Pro Pro Val Ala Val Leu Pro Leu 
465                 470                 475                 480


Gly Thr Gly Asn Asp Leu Ala Arg Cys Leu Arg Trp Gly Gly Gly Tyr 
                485                 490                 495


Glu Gly Gly Ser Leu Thr Lys Ile Leu Lys Asp Ile Glu Gln Ser Pro 
            500                 505                 510


Leu Val Met Leu Asp Arg Trp His Leu Glu Val Ile Pro Arg Glu Glu 
        515                 520                 525


Val Glu Asn Gly Asp Gln Val Pro Tyr Ser Ile Met Asn Asn Tyr Phe 
    530                 535                 540


Ser Ile Gly Val Asp Ala Ser Ile Ala His Arg Phe His Val Met Arg 
545                 550                 555                 560


Glu Lys His Pro Glu Lys Phe Asn Ser Arg Met Lys Asn Lys Leu Trp 
                565                 570                 575


Tyr Phe Glu Phe Gly Thr Ser Glu Thr Phe Ala Ala Thr Cys Lys Lys 
            580                 585                 590


Leu His Asp His Ile Glu Leu Glu Trp Cys 
        595                 600


<210>  2338
<211>  511
<212>  DNA
<213>  Homo sapiens

<400>  2338
cattcaaact ggagacactt agctacttag cccctccgaa aattcagcca gtggaaaaac     60

acctgactgc ctgccctcct gcttctcatc tgcctctccg aagctgtctt ggcttcaact    120

ctcatctcac gccccctatt ggatgaagca gagctaattt ctttttcttt tacctttcaa    180

gtataagatc atccccaccc cgggtaccca ccccctgctg gtcttggtga accccaagag    240

tggagggaga caaggagaaa gaattcttcg gaaattccac tatctgctca accccaaaca    300

agttttcaac ctggacaatg gggggcctac tccagggttg aactttttcc gtgatactcc    360

agacttccgt gttttggcct gtggtggaga tgggacagtt ggctggattt tggattgcat    420

tggtaagcat gggctgagag ggcgtttgct gcttatttat agtaagcgta tttacaatca    480

gcagaaggca ataaaaaaga aagagacatg g                                   511


<210>  2339
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  2339

Phe Leu Phe Leu Leu Pro Phe Lys Tyr Lys Ile Ile Pro Thr Pro Gly 
1               5                   10                  15


Thr His Pro Leu Leu Val Leu Val Asn Pro Lys Ser Gly Gly Arg Gln 
            20                  25                  30


Gly Glu Arg Ile Leu Arg Lys Phe His Tyr Leu Leu Asn Pro Lys Gln 
        35                  40                  45


Val Phe Asn Leu Asp Asn Gly Gly Pro Thr Pro Gly Leu Asn Phe Phe 
    50                  55                  60


Arg Asp Thr Pro Asp Phe Arg Val Leu Ala Cys Gly Gly Asp Gly Thr 
65                  70                  75                  80


Val Gly Trp Ile Leu Asp Cys Ile Gly Lys His Gly Leu Arg Gly Arg 
                85                  90                  95


Leu Leu Leu Ile Tyr Ser Lys Arg Ile Tyr Asn Gln Gln Lys Ala Ile 
            100                 105                 110


Lys Lys Lys Glu Thr 
        115


<210>  2340
<211>  1462
<212>  DNA
<213>  Homo sapiens

<400>  2340
gaaacagagg agataacaaa aggaatcaaa atcatggtac ctgagctgag acacacacag     60

taaccctcca tgcaagagaa actggcctcg agctgagaga tggatcccaa gttgctacag    120

ctgtggggat gagtgataag aagtgacagg agaaatctgc cttgatttga gatggattgc    180

attgtcaacc aaatgctgca tattgcccag tacctggagt gggatcccac agagctgagg    240

cctatattga aggagatgct gcaagggatg gactacgacc gggacggctt tgtgtctcta    300

caggaatggg tccatggagg gatgaccacc atcccattgc tggtcctcct ggggatggat    360

gactctgtaa gtcaacaagc tggagttcag agatctcttg ccattcagga acattgggct    420

tcatgttaat atcaacatat cactttggct tctgctccag actgcccaac agacgtgcca    480

tgaccagccc caaagtcctc tctatttaca ttattttgta tccattagtg cctgaagtat    540

attcatttga cagacattta ctacattatt actactttaa aaatactgtt ctgcatgctg    600

tgagggaata cagacacatt atctgcctgc aagaacctta tactcaacca ggcaaagggc    660

cacaaacttc aaagaagaat tctgtctttt caacaaatta ggtttaaaaa tgctaagaga    720

attggggaag gaagggtgag aggaaagaac gaagggagag aggaaaaaat acggatctgt    780

tgtgggggtg gcttccatta gtggtatctt atttaataat caaaacaacc agataaggta    840

aatattttta tcccaattta tacagatgga aaactgaggt tctgacccta aggagcaaaa    900

ggaggagtga ggatttgtct ctgacaccaa agatgttgca ctttgtaata tcccacacat    960

gagagttagg ccagtgggaa gaaaccttgg aaggtgttga cttgtccctg aagaatgcat   1020

gagattttga tgtcccattc ttgagaataa agagcaggtg gccttaaaga cctagagaga   1080

gtttatggct tggagaacag cttgattaaa aacacaaatg aaagaaagtt ctgggtgtgt   1140

taggcaaatc tcccatttga tcagagtagg gcatatgtgt acaggcttaa tgtgaaactg   1200

attgttatat ataccttcat ctgacccagt tactgtattc tccacctatt taccaagtga   1260

actcacttcc atgcatgagg tagggaagac taaaactagt aggagcacaa atggtgacat   1320

taagcgttta ctagtcacac cagttgtgtg acaacactac tttgagatta cagatctcaa   1380

agattacacc tctttgagac tattccatag agaggaacag ggcagcaagt gcagctgggt   1440

gagcctctag ctgaccaagt tg                                            1462


<210>  2341
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  2341

Met Asp Cys Ile Val Asn Gln Met Leu His Ile Ala Gln Tyr Leu Glu 
1               5                   10                  15


Trp Asp Pro Thr Glu Leu Arg Pro Ile Leu Lys Glu Met Leu Gln Gly 
            20                  25                  30


Met Asp Tyr Asp Arg Asp Gly Phe Val Ser Leu Gln Glu Trp Val His 
        35                  40                  45


Gly Gly Met Thr Thr Ile Pro Leu Leu Val Leu Leu Gly Met Asp Asp 
    50                  55                  60


Ser Val Ser Gln Gln Ala Gly Val Gln Arg Ser Leu Ala Ile Gln Glu 
65                  70                  75                  80


His Trp Ala Ser Cys 
                85


<210>  2342
<211>  549
<212>  DNA
<213>  Homo sapiens

<400>  2342
ttggtgcatg actgtagaac tttaagcaat gatgaaaatg ctctatatcc acactatcca     60

atatggttct gcttgaattc ttgccctggc tcttggtgaa ggatcggcct gctggatctg    120

agtcatccac ctataagagg gacaacacca cacattggtc gctgctctca agcccctgga    180

ataccacccc acttggcttc tcctggtaac agtggctgcc tttgcttgcc tgtctccaac    240

tcctcccaag agcattgctg actataccac ccacataaac aaaaactttt tgggagtcct    300

ccagaatttt taagagttat ctaaactatt gcctttaatg accaggaact ccaatttgag    360

aagttaccct acgttaagcc aacagcagcc tggctccttc atcctgtgca gtatgggaca    420

gagctgggtc cttgttgtca tcagccagac aagcacacat taaagcccac cttagccatt    480

ggcattacag ctttaaaagc agctccatcc taccatgctg tcactctact caatcacgtg    540

atcttaacg                                                            549


<210>  2343
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  2343

Met Val Leu Leu Glu Phe Leu Pro Trp Leu Leu Val Lys Asp Arg Pro 
1               5                   10                  15


Ala Gly Ser Glu Ser Ser Thr Tyr Lys Arg Asp Asn Thr Thr His Trp 
            20                  25                  30


Ser Leu Leu Ser Ser Pro Trp Asn Thr Thr Pro Leu Gly Phe Ser Trp 
        35                  40                  45


<210>  2344
<211>  604
<212>  DNA
<213>  Homo sapiens

<400>  2344
aaatgctcta tatccacact atccaatatg gtaaccacta gccacttgtg actactgagt     60

gtctgaaagg ttctgcttga attcttgccc tggctcttgg tgaaggatcg gcctgctgga    120

tctgagtcat ccacctataa gagggacaac accacacatt ggtcgctgct ctcaagcccc    180

tggaatacca ccccacttgg cttctcctgg taacagtggc tgcctttgct tgcctgtctc    240

caactcctcc caagagcatt gctgactata ccacccacat aaacaaaaac tttttgggag    300

tcctccagaa tttttaagag ttatctaaac tattgccttt aatgaccagg aactccaatt    360

tgagaagtta ccctacgtta agccaacagc agcctggctc cttcatcctg tgcagtatgg    420

gacagagctg ggtccttgtt gtcatcagcc agacaagcac acattaaagc ccaccttagc    480

cattggcatt acagctttaa aagcagctcc atcctaccat gctgtcactc tactcaatca    540

cgtgatctta acgaccagct ctacatatcc tctctccatg cccccaccac catcccccac    600

caac                                                                 604


<210>  2345
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  2345

Met Thr Arg Asn Ser Asn Leu Arg Ser Tyr Pro Thr Leu Ser Gln Gln 
1               5                   10                  15


Gln Pro Gly Ser Phe Ile Leu Cys Ser Met Gly Gln Ser Trp Val Leu 
            20                  25                  30


Val Val Ile Ser Gln Thr Ser Thr His 
        35                  40


<210>  2346
<211>  575
<212>  DNA
<213>  Homo sapiens

<400>  2346
aatatggtaa ccactagcca cttgtgacta ctgagtgtct gaaaggttct gcttgaattc     60

ttgccctggc tcttggtgaa ggatcggcct gctggatctg agtcatccac ctataagagg    120

gacaacacca cacattggtc gctgctctca agcccctgga ataccacccc acttggcttc    180

tcctgagatg ggctctcact atagccctgt tctggaactc ctgggctcaa gccatcctcc    240

cactttggcc tccccaaaat gctgggatta caggcgtgaa ccaccgcatc tagcctaaaa    300

ttatattgtt aaaagacttt gtttctcagt ttgggataat cagaattcat agttctgatc    360

tcgactacca gttttaatga ggtacttctt tctaactcca tcagctgtgt ggctatctgc    420

agataccacc cacataaaca aaaacttttt gggagtcctc cagaattttt aagagttatc    480

taaactattg cctttaatga ccaggaactc caatttgaga agttacccta cgttaagcca    540

acagcagcct ggctccttca tcctgtgcag tatgg                               575


<210>  2347
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  2347

Met Arg Tyr Phe Phe Leu Thr Pro Ser Ala Val Trp Leu Ser Ala Asp 
1               5                   10                  15


Thr Thr His Ile Asn Lys Asn Phe Leu Gly Val Leu Gln Asn Phe 
            20                  25                  30


<210>  2348
<211>  422
<212>  DNA
<213>  Homo sapiens

<400>  2348
cttgaattct tgccctggct cttggtgaag gatcggcctg ctggatctga gtcatccacc     60

tataagaggg acaacaccac acattggtcg ctgctctcaa gcccctggaa taccacccca    120

cttggcttct cctgattctg ctatcagcta caggtctggg tttgtgtctc cgacaaagaa    180

ccacctcaaa gccccacaga aaaggactgt accgtatact tcaaactatt gacacctcaa    240

agaacagagc ttgggttcag gcttctgatg cattctgaga cactctcaga ccataccagt    300

gggctgggtc aggatttaca gaactatttt catttcaaga gcatacgggc tcatgagatt    360

gctaactcaa gatccggtgg aacagaaata cttatatcgg actgaataaa ctgatgagga    420

aa                                                                   422


<210>  2349
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  2349

Met His Ser Glu Thr Leu Ser Asp His Thr Ser Gly Leu Gly Gln Asp 
1               5                   10                  15


Leu Gln Asn Tyr Phe His Phe Lys Ser Ile Arg Ala His Glu Ile Ala 
            20                  25                  30


Asn Ser Arg Ser Gly Gly Thr Glu Ile Leu Ile Ser Asp 
        35                  40                  45


<210>  2350
<211>  368
<212>  DNA
<213>  Homo sapiens

<400>  2350
tcaatggcaa aagggcatac tgctgttatt gtcagtgagg ggtcagtagt ttaaatgatg     60

aaactctggg gatcagcgta aagtaaacca acatactgca tgtaagtatc aagtaaatga    120

gcagagacag cccctggttt acaaacacct gacttaagca tcgtccatcc tacaggacag    180

ggaaggagga agaagcttcg agaggctgga acagttgagg gagcgctgac acggtaaagg    240

ccactttgct catcatcacc aggcgtgctg ccgaaaattt ccactctgtt tactcccaag    300

accttactcc tactatgtgg agacacattt gaataaaaaa ttggcctctt ttcaaagtca    360

aaattctg                                                             368


<210>  2351
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  2351

Ala Glu Thr Ala Pro Gly Leu Gln Thr Pro Asp Leu Ser Ile Val His 
1               5                   10                  15


Pro Thr Gly Gln Gly Arg Arg Lys Lys Leu Arg Glu Ala Gly Thr Val 
            20                  25                  30


Glu Gly Ala Leu Thr Arg 
        35


<210>  2352
<211>  721
<212>  DNA
<213>  Homo sapiens

<400>  2352
gggaggtgca agctgagcct gcactacctt ttgtcacggt tgctatggaa aagattaaga     60

gcccggatag cccttcctcc tctgggggcc tgggcatcag caagtcggat ggcagtggaa    120

ggtggagaaa tggaatcctg ctgggggctc aggaggcctg ccccctgatg ctgccgtgca    180

ctgcagatgt ccttgatgaa gagaatgaat ggaagctgtc tttctcaatg gcaaaagggc    240

atactgctgt tattgtcagt gaggggtcag tagtttaaat gatgaaactc tggggatcag    300

cgtaaagtaa accaacatac tgcatgtaaa ttcctcattc ttactgctgt gagaacaatt    360

gttaggagcc aaaaacttca gagctttcaa agaactgtaa tgagatagca caatgcaggc    420

aaaaagccag tgttaacgga gcaagaaact tcccagttct gacattcaca gcatgaccta    480

gagcatgcgg attcccctct ctgagtcact ggtttctcac ctgcaaaaga aagcggggac    540

agggaaggag gaagaagctt cgagaggctg gaacagttga gggagcgctg acacggtaaa    600

ggccactttg ctcatcatca ccaggcgtgc tgccgaaaat ttccactctg tttactccca    660

agaccttact cctactatgt ggagacacat ttgaataaaa aattggcctc ttttcaaagt    720

c                                                                    721


<210>  2353
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  2353

Met Glu Lys Ile Lys Ser Pro Asp Ser Pro Ser Ser Ser Gly Gly Leu 
1               5                   10                  15


Gly Ile Ser Lys Ser Asp Gly Ser Gly Arg Trp Arg Asn Gly Ile Leu 
            20                  25                  30


Leu Gly Ala Gln Glu Ala Cys Pro Leu Met Leu Pro Cys Thr Ala Asp 
        35                  40                  45


Val Leu Asp Glu Glu Asn Glu Trp Lys Leu Ser Phe Ser Met Ala Lys 
    50                  55                  60


Gly His Thr Ala Val Ile Val Ser Glu Gly Ser Val Val 
65                  70                  75


<210>  2354
<211>  2285
<212>  DNA
<213>  Homo sapiens

<400>  2354
aagttgtttt ctaatgctca cgcgctatgg ccgaagtctg caatggatgg gagaaagggg     60

aggaccaaat tagctcagat tctttacagt tcacagcatc agctgtttta tttatttgtt    120

ttagatagcg aagccaaaaa aagttggatg ggggcaaaaa tgccaactaa aatagctcat    180

agttctgaag tagagagaag tcagaatttc ccgttttctc ttgtttctct cagggatggt    240

ctatatgact ggcgctcctt ggaagcagtg ctgagggcat tatcaagagt ttccagggcc    300

tcctctttct cctgaaacct tcttcaagga gggtaaagtt ttaagagagt tcaaaagtac    360

cacagacttc cagggaatag tagtttttgt cgtgacaagc atggacattt tcttgcgtca    420

tgtactattt cagaaggtag agaccacaaa aaggcttctt actgtggcca ccgtggacat    480

cttcccacat ctacaaggtg ttgtggccac atcattgctg cacccagttt cctcagaaga    540

aatacctgtt gcttaggttt agaaacgagg catgtatacg tatttaacag ttctcagaat    600

gtcaaggatc cctcctcaga gcaagagctc gaatttacaa aagaagcact acctccttta    660

tcacatagta aaataaagga ccgtgtctgc tccaggacat ggctggttac aattttgttt    720

taaagaaatc accagagaaa cctgagattc caacccagcc ttttgtttgc ctgggattat    780

agcccagttc ttacaagcag agaagcctag gacactaacc cagcttcaag agtatactca    840

gaatctcaag aatcacaatc tgtgctgccc attcttcaac agactgtcat ctggaggcct    900

ggattggatc aggagtcggg ctcaccaatg gagccccaat cagtcagtca ggagtgaaga    960

tgaaagcttc aaagccagca caagagcaca caggaggccg gcataatcac gaattgcagc   1020

tgtctgaagg gcagtcacat aaaagaggag aagcttcacc tttgcttcac aaggcacatc   1080

ttgaaccagg gatggaaatt acagagaggc caaaaccagc tcggtgtgag caggactggt   1140

aacagactgg ccaagcaaca gaaggggctg ccctgtgaag aagcaagctc tctgtcaatg   1200

ggaggtgcaa gctgagcctg cactaccttt tgtcacggtt gctatggaaa agattaagag   1260

cccgggcctg gctgttccca cctcaaacca cttcttagct tcatttgttc tcataacaac   1320

aggatagccc ttcctcctct gggggcctgg gcatcagcaa gtcggatggc agtggaaggt   1380

ggagaaatgg aatcctgctg ggggctcagg aggcctgccc cctgatgctg ccgtgcactg   1440

cagatgtcct tgatgaagag aatgaatgga aggtattgga agggagctga agttcaacaa   1500

atgaccacct aatgaaaaag tcagcagtgg attgcttgag atcttgagca ccctgtactg   1560

ttattagtat ttataaacat gtttgaaaga tgttcccttc cttcactgta gtgccagaaa   1620

gcctttaaca tattgggtcc ggtctagatt tgtaaggaag tatggctgaa ttgttatcgg   1680

gtggatacag tttacatgtt taaagctgtc tttctcaatg gcaaaagggc atactgctgt   1740

tattgtcagt gaggggtcag tagtttaaat gatgaaactc tggggatcag cgtaaagtaa   1800

accaacatac tgcatgtaag tatcaagtaa atgagcagag acagcccctg gtttacaaac   1860

acctgactta agcatcgtcc atcctacagg taaattcctc attcttactg ctgtgagaac   1920

aattgttagg agccaaaaac ttcagagctt tcaaagaact gtaatgagat agcacaatgc   1980

aggcaaaaag ccagtgttaa cggagcaaga aacttcccag ttctgacatt cacagcatga   2040

cctagagcat gcggattccc ctctctgagt cactggtttc tcacctgcaa aagaaagcgg   2100

ggacagggaa ggaggaagaa gcttcgagag gctggaacag ttgagggagc gctgacacgg   2160

taaaggccac tttgctcatc atcaccaggc gtgctgccga aaatttccac tctgtttact   2220

cccaagacct tactcctact atgtggagac acatttgaat aaaaaattgg cctcttttca   2280

aagtc                                                               2285


<210>  2355
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  2355

Met Lys Ala Ser Lys Pro Ala Gln Glu His Thr Gly Gly Arg His Asn 
1               5                   10                  15


His Glu Leu Gln Leu Ser Glu Gly Gln Ser His Lys Arg Gly Glu Ala 
            20                  25                  30


Ser Pro Leu Leu His Lys Ala His Leu Glu Pro Gly Met Glu Ile Thr 
        35                  40                  45


Glu Arg Pro Lys Pro Ala Arg Cys Glu Gln Asp Trp 
    50                  55                  60


<210>  2356
<211>  572
<212>  DNA
<213>  Homo sapiens

<400>  2356
caccctcccc cgcccaccgc ctcagcaacc aacctccagg gaggggaaag ggggcagaag     60

tttgagttaa taactaatag ctaaagatgt aaacaataag cctccataaa accccaaaag    120

gactggactg gtttctgaga gcttccaggt tgttgagcac gtggaggttc tgggagggtc    180

cacacccaga gaaggcatgg aagctgaccc cttccccata ccttgctctt tgcatctctt    240

ccatttggct gttcccgagt tgtatacttt gtaataagtg ggatttccac ccaacaacaa    300

ttcagccaca ctgcttcaca catctagaat ccatccaaaa ttgtaaaggc tttgtggcac    360

tacagtgaaa caggcaagaa catcttccaa acatccagca caagagcaca caggaggccg    420

gcataatcac gaattgcagc tgtctgaagg gcagtcacat aaaagaggag aagcttcacc    480

tttgcttcac aaggcacatc ttgaaccagg gatggaaatt acagagaggc caaaaccagc    540

tcggtgtgag caggactggt aacagactgg cc                                  572


<210>  2357
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  2357

Asn Arg Gln Glu His Leu Pro Asn Ile Gln His Lys Ser Thr Gln Glu 
1               5                   10                  15


Ala Gly Ile Ile Thr Asn Cys Ser Cys Leu Lys Gly Ser His Ile Lys 
            20                  25                  30


Glu Glu Lys Leu His Leu Cys Phe Thr Arg His Ile Leu Asn Gln Gly 
        35                  40                  45


Trp Lys Leu Gln Arg Gly Gln Asn Gln Leu Gly Val Ser Arg Thr Gly 
    50                  55                  60


Asn Arg Leu 
65


<210>  2358
<211>  433
<212>  DNA
<213>  Homo sapiens

<400>  2358
cgatgtgaat gtgatcattc tctgagtctc agttttccat ccatgaatcc ttgtgatttt     60

taatttttca tgtaggactg tcacgagaag taagattttt aaatttccag aacagaaata    120

ggtaagggaa acatctaagt gtgactcctc caaaatcact cttgcttcca attttgtctg    180

ctgttatgga ggtcagcaac tagtataaaa tcctgaggtc agcccttccc tcaaatcttc    240

aaaacacagt tcgctgatga tgctgcttct taaaccttca tcatctcagg gcgcctggct    300

ggggccagga aggcgttcgc gtcagacaac cccagcgggg aagcccccct ctcccgcggg    360

ccaaaccgca gcttcttgca gccactcgcc ccggccggtt tcgggaggag ggcggcgctc    420

cgaaggcggc cgc                                                       433


<210>  2359
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  2359

Met Met Leu Leu Leu Lys Pro Ser Ser Ser Gln Gly Ala Trp Leu Gly 
1               5                   10                  15


Pro Gly Arg Arg Ser Arg Gln Thr Thr Pro Ala Gly Lys Pro Pro Ser 
            20                  25                  30


Pro Ala Gly Gln Thr Ala Ala Ser Cys Ser His Ser Pro Arg Pro Val 
        35                  40                  45


Ser Gly Gly Gly Arg Arg Ser Glu Gly Gly 
    50                  55


<210>  2360
<211>  701
<212>  DNA
<213>  Homo sapiens

<400>  2360
gcactgagcc aggcactacc atatccataa tctcctctga gacttggaaa ccaagctggg     60

gccaggttac aaatgacttc acatgccatt ctccccgctg cctgccactt gtaccttggg    120

cagccactgg ggacattcct ggttctggat tcctgcctct gagcagctct cttaacatga    180

gtaggaggcc tgtgcttccc cacacccgtt tccatctgtt tgcatggacc agagccactt    240

gagatagggc cttcctagga atagaaggta agaccagcat cattccaggg ccactgtgga    300

tgggctttcc ccgcccagga aatgactgct gcattgatct ctgtgccact caggccaggg    360

catccttgtg gggaggattc cagtctgcat tgcatcaaat acctagtata aaatcctgag    420

gtcagccctt ccctcaaatc ttcaaaacac agttcgctga tgatgctgct tcttaaacct    480

tcatcatctc agccaagcca gggctggatc cagggaaact catcaccatt cctggaagag    540

gacatcccaa cagctgccag cattagctct ctcagggcgc ctggctgggg ccaggaaggc    600

gttcgcgtca gacaacccca gcggggaagc ccccctctcc cgcgggccaa accgcagctt    660

cttgcagcca ctcgccccgg ccggtttcgg gaggagggcg g                        701


<210>  2361
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  2361

Met Met Leu Leu Leu Lys Pro Ser Ser Ser Gln Pro Ser Gln Gly Trp 
1               5                   10                  15


Ile Gln Gly Asn Ser Ser Pro Phe Leu Glu Glu Asp Ile Pro Thr Ala 
            20                  25                  30


Ala Ser Ile Ser Ser Leu Arg Ala Pro Gly Trp Gly Gln Glu Gly Val 
        35                  40                  45


Arg Val Arg Gln Pro Gln Arg Gly Ser Pro Pro Leu Pro Arg Ala Lys 
    50                  55                  60


Pro Gln Leu Leu Ala Ala Thr Arg Pro Gly Arg Phe Arg Glu Glu 
65                  70                  75


<210>  2362
<211>  490
<212>  DNA
<213>  Homo sapiens

<400>  2362
caaaatctca tgcatatttt aatacttatg acttcatatt tcatttgaat gagtgcgatg     60

attaaatttg ggacagagag aaaaagaatc ctgtgtgttt acacaaacct agtataaaat    120

cctgaggtca gcccttccct caaatcttca aaacacagtt cgctgatgat gctgcttctt    180

aaaccttcat catctgaaat agctggccca tcaggaaggt actttgttgg gtgattccat    240

ttggccagag aaaagtgatc tttgttttcc aaccctttct cctgttccaa ggacgaaatg    300

gagctgcaga atctgtcctc cccctcttgt atctctcctg gctgccaaca gaaagactcc    360

tgttctataa gccagcagct tcatgaggtc tgaaaataat ccctcagcca agccagggct    420

ggatccaggg aaactcatca ccattcctgg aagaggacat cccaacagct gccagcatta    480

gctctctgga                                                           490


<210>  2363
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  2363

Met Arg Ser Glu Asn Asn Pro Ser Ala Lys Pro Gly Leu Asp Pro Gly 
1               5                   10                  15


Lys Leu Ile Thr Ile Pro Gly Arg Gly His Pro Asn Ser Cys Gln His 
            20                  25                  30


<210>  2364
<211>  2669
<212>  DNA
<213>  Homo sapiens

<400>  2364
aacctatggc ttttggggga tacagttcag tccatagcag tggggaaagg atgtgactca     60

gtctagagag actcaaggag ggaatgctta gataggagca tggagggcgt gcctggtgaa    120

gggaacagta tggcacagct tcagaggcaa gggtgagcca gcagcaaggg gctggctatg    180

gccggtacaa aaagcatgtg ctcgtgggaa ataggcacca aagaaggccc agagaggttt    240

aacaacttcc tcagaatcac acagcttcca aatggttggg ttgggtttac atttaggcgg    300

tcttgctcca gagccagtgc tcctaacctt tgcaagccac gaacctcaag aaagtggaga    360

aggaaacgct gggaaatctg gaagtcagac atggcaattt atctcccggg agctgacttc    420

atttctaaac gtataggggt ttcttagagg agcttcagaa tactaatcat cgctagtgag    480

ggcacttgga cactttgctt cacctcagcc agcacctctt ttcccagctg taaaatggta    540

tgataataag cacccctagg aatctcaagg atgttacgag ggaaaaatat gcaataatat    600

acaaagcact ttgagcttct ctgaagacag acgcatataa atggaaggtg gtattataag    660

gtggggtaat cactggttac ctccccccct tttttattta attaggagaa aaccagtaat    720

taggaagcat ggccttgtta aagctgtggc ctgggaaata gttctcttgg cacctaatca    780

gaactgtgac atggcgcaaa tttttgcaaa atgtgggcag caggggacct tccccaaggc    840

tcagactgtg agaaatttgc gtctaggggc cagatcctga ggtggctgag ctggctgggg    900

aggcttctaa ggagatcttc actcaggtct gcaagggggc tctgccctgc ctcagtagcc    960

ctcatctctg ggggccccaa agtcattctc atctgcaggt tagagcttgc tgcaggccca   1020

gaaccaagct tgtccaccac gtggccttct tggacccact ggggcaactt cagggttctg   1080

aaaagcacct cagatctagt ctggtctctg attcagtagc agagacaaag aaatcccctg   1140

cctgttcccc ttaaaatggg ccattgtgga gtaggtgctg gggccctagc ttgctcccca   1200

ctgtgccttt gttagagcat tagcctccag cggaacccac tgtctctctc cttgcgagtc   1260

ccagtttgcc cattctcccg gatcctgctt aaaggccgcc tctgccagga ggccttccca   1320

ggtcttccca gttaccatca ctctcttcct cctctagact ctgtgtttgg tacagtgtgg   1380

tttttgtgtt tgtcctgtct tctctcacat ttgactctga gccactggaa gaaagggaag   1440

gaaagtaaga gaaatgaagt attcccattc ccaggcacct ggccagttgt tgcagacaga   1500

atgaccagca ctgttgtatt gattccccct caatacgttg aaaaagcaaa cgggaggcat   1560

ctggaaaatc ttgagataag cagcttcatt ttcaatgatg agtcttttaa aatacacaga   1620

aatggtataa caatcatgta tccaccactt agactaccaa tggttacttt tgtcatattc   1680

actttaaatg tctttttatt atgtatttaa aagaagtgaa acttgtagat acagctaggg   1740

ctccccgtgt ccactcactg aagtcccttc ccttttgtca tattcacttt aaatgtcttt   1800

ttattatgta tttaaaagaa gtgaaacttg tagatatagc tagggctccc cgtgtccact   1860

cactgaagtc ccttccctct cccttctagg gtccaccact ttccttgtca tctggtaaag   1920

gaccctgcat ccatggatgg acagagggga ttgctaaagt gctgaatcgc gtgtgaaatt   1980

ctacgtgtgc ctctttctca cacatgccac atccattgca gagatgctct tgactcaacc   2040

ttccagcagt ctccactgca accactctgg ccaaggccac cattttcttt tcttttcttt   2100

ttctctctcg ccatggttgg agtgcagtgg tgcgatctag gctcactgca acctctgtct   2160

ccagggttga agcgattctt ctgcctcagc ctcccgagta gctgagatta caggtttttc   2220

tcactgtaag aagaggacaa tagcctatga tctacagtgc ccattccaac tcagagaatc   2280

tttacatctg gagatctata gcagggctat ccctagtgac atgcgtgaag aagcttggaa   2340

atggtgctgg gtaggagctg agtgtgcaga atgtggaaag gcattctaaa ccaaaggaag   2400

aacacgagta aagatgatga agcagggata aggctaaaat gaaatttgtg atctgatcca   2460

catacaagca cagtgtagta cagctggaat atagagaaga gcttgaagac ttatgagcaa   2520

ctatcccggt actcttggag gctctgcaac cacagtttga gaaactccgc gttcaaagtt   2580

aaaaactgtc acctgaatag ttaataacat caaagattgt gaaagcaagt ataaataaca   2640

cagagattaa aataatgagg caggatcag                                     2669


<210>  2365
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  2365

Met Ala Gly Thr Lys Ser Met Cys Ser Trp Glu Ile Gly Thr Lys Glu 
1               5                   10                  15


Gly Pro Glu Arg Phe Asn Asn Phe Leu Arg Ile Thr Gln Leu Pro Asn 
            20                  25                  30


Gly Trp Val Gly Phe Thr Phe Arg Arg Ser Cys Ser Arg Ala Ser Ala 
        35                  40                  45


Pro Asn Leu Cys Lys Pro Arg Thr Ser Arg Lys Trp Arg Arg Lys Arg 
    50                  55                  60


Trp Glu Ile Trp Lys Ser Asp Met Ala Ile Tyr Leu Pro Gly Ala Asp 
65                  70                  75                  80


Phe Ile Ser Lys Arg Ile Gly Val Ser 
                85


<210>  2366
<211>  909
<212>  DNA
<213>  Homo sapiens

<400>  2366
ctgaaaagcc gacctacatg cagagaaagg cgggaggggc tgctgggaga agtctgctgg     60

agcttgttca tgctgagagg ttgggggtgt gatttgaggt gcggaagacc tacttaaaac    120

ctgagagtct cgaataggag aggcgctttc agatcagccc gagtcttctg cagcgcacag    180

gagctagtcg tactgaaaag aatgaagttg gacttgtcca ggcgagtttc ggacagtgct    240

gggctgccct gctctgatct cctgggtgtc ttcacctcct ctggttccta agtcggctgc    300

tgcaccagca cccatcaaac tctcctggaa gaggaagtga cagctcaccg gtagcctaga    360

aggcccctgt gggcagaagc atggacttac tcctcctcat ggagatgcgg ctgagccata    420

tttccttggc acctctctgg aaccttcgac aaccaccacc tcagacacta accagacttt    480

aggtccattc ctttcatggc taaaatgaga cagtccacaa tgttgatttt atttgtaggg    540

gatgtcagga ttccagaaaa gcagacttgg aaagcaacaa aacgttaact tgcagctcac    600

tgaggccctt acacttgttc tgggcacctc tgtatgttaa aagaagtcca atatctttag    660

ctgctggtta taggtggcca tatgtttctg cacagaaatg gggctcccct tgctagacta    720

attttctaat ttttcctcaa gcttcattga ttcatattct tctacttgac cctgactgtc    780

aggaccaaca acaccaaata acaccaaagt ctcttgctcc tgtcctcaga acctctcaga    840

ggcatcctct gccctgttgg agccatttta tttcaggttg atccttaatt aaattcagcg    900

agatgcagg                                                            909


<210>  2367
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  2367

Met Asp Leu Leu Leu Leu Met Glu Met Arg Leu Ser His Ile Ser Leu 
1               5                   10                  15


Ala Pro Leu Trp Asn Leu Arg Gln Pro Pro Pro Gln Thr Leu Thr Arg 
            20                  25                  30


Leu 



<210>  2368
<211>  1058
<212>  DNA
<213>  Homo sapiens

<400>  2368
agaacaccac aggcaggacc tcccagcaaa ggcctccaga tgctgtgaaa acctaaggct     60

cgtcctcctc ctggcttccc aggttaccca gccacaacac acagatgctg ggtctgggac    120

ggctccactg gaacctgaga tgacctgagg gtgtcccagt gatataacat atgaggaaag    180

cagaaacaac taagaaatag actctgaatg tggcagattc tagaactgag aggcggaaga    240

ggagcagatc ttcactttcc acacctcaag gtactcagcc aatcacctgt tcatgcctga    300

gattgtgaat ccaataggaa agtacaagga catggagatt gtcagagctg ttgtatgatg    360

gtggcagcag agtcaagagt ccagcggaga ggcagcaagc atcccaagga tcccatgact    420

gagaaccagc ttctgtggtt tagaagcaag gcgccaactg gtatgagaag cacagacaga    480

tggtgccctg ggaacactgg ctgtcacgtg ctggaggagg ttcctcagca agtcaccttc    540

cctccatggg cctctgttgg aaagaaggca tcaagatcat tccagctatg attcctgagc    600

ttttaatata ttctttctga tgattaagaa atatatctgt cgagcatggc agcttacgcc    660

tgtaatccta gcactttgtg aggccgaggc gggtggatca tgaggtcagg agttcaagac    720

cagcctgacc aacatggtga aacctcgtgt ctactaaaaa tacaaaaatt agccgggtgt    780

tgtggtgtgt gcttgtaatc ccagctactc gggaggctga ggcaggagaa acacttgaac    840

ccgggaggcg gaggttgcag tgagctgaca tcacgccact gccctccagc ctgggtaaca    900

gagtgagact ccatctcaaa gaaaaaaaga gatatatctg catgtgacat ggaaagaggc    960

tcagaatatc agacatttta ctacagatct tgaaaacagc tctccaaaac taactccaga   1020

tccaccctgg ggttctcaac tccacatggt tttctaaa                           1058


<210>  2369
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  2369

Met Trp Gln Ile Leu Glu Leu Arg Gly Gly Arg Gly Ala Asp Leu His 
1               5                   10                  15


Phe Pro His Leu Lys Val Leu Ser Gln Ser Pro Val His Ala 
            20                  25                  30


<210>  2370
<211>  2450
<212>  DNA
<213>  Homo sapiens

<400>  2370
aggctcctcc actgctcccc aggcactgag atttctttaa aaccatcaga cgggttttca     60

caaccccaaa ccgatgtgtg tttgagtttc ttccaaattc ccacaaacgg cagggagata    120

cacctgtcct cctgggaatg gggtgaagga aaagggctgt ctgagctggc tacacttccc    180

gggggaccac aaggttcctg gctgctgccc catctcctgc agatgagggt ggcatctgga    240

gtcagggagg cttgatctgg ggcctgggtg tctgtcgctc gctgggtgcc agttcctgcc    300

tgatgattct aaatctggac actggcgtaa aagataacat ctataggaaa ccccctatct    360

acagacagca tgctgccagg cgatcggatg gggaggatgg aagcttggac caggataaca    420

ggaagcagaa gagcagctgg ctgatgctca agggggatgc agacacaagg accaattctc    480

cagacctgga cacccagtcc ttgtcccaca gcagcgggac cgacagagac cctctccaaa    540

ggatggcagg ggacagcttt cactcacaat acaagatcta tccgtatgac tccctcatcg    600

tcacaaaccg aattcgcgtg aaactgccca aagacgtgga ccggacgaga ctggagagac    660

acttgtcgcc cgaggagttc caggaagtgt ttgggatgag catcgaggag tttgaccgcc    720

tggccctctg gaagaggaat gaccttaaga agaaagccct tttgttctga cggctgccag    780

cctgccccac tggtgtgtgc cgggcgccga ggccaggggc ccctggcgag aaccgcacac    840

acccctccca cacaccttgc tctggcttct ctgtgtccat ggggtgggcg ggagggggtc    900

ccccagcagg tgcggcccct gcacctgccg gcgacactcc tgccggtagt ttagggccga    960

gacggctagc ttcacgccac ccttccccgc tgtggcttgg tgtcagggag aggctgtaga   1020

gtggctgtgt cgggcatcag atggagcaca caggtggctg cagcccagcc caccttccca   1080

gcgttctcga ggtgccctgg ccccggtgct gggcacgtgg gggacagagg tggccgggac   1140

gtgagctgtg aggcttgttg atgatggttg ctgacaccat catcgggggt gggcacacgg   1200

cccttcggag cctgggcagc ctggcctcac aggcagactc gcagacgggg cagtgagcgt   1260

ctgggacagt gccaagagtg gggtgtgtga tttttgcagg cgtctgtgat gggtctcttt   1320

agggacaaat gtcaacaagg gacaagacag ggcaccttcc gccagcgccc ctccatgcgc   1380

tgcgttcctc ctccagatcg acccctagat gcctacacaa tatctttaaa gtaacacaga   1440

agtttttatt ttattaaaaa gtatagccta cttaaacgcg agatgacata tatagagttt   1500

aattttacgg tccctccgca ggggagcggc ctccagcctt attctccacc gctcggatct   1560

gtgtggtttc agtctgttct tggtgtggtc ctcatacaca gagctccctg tctagtttct   1620

tttctttttc ttttttcttt ttctcgtcac acaggtaacc ttaaagacag acccctctaa   1680

agaacgcttt gtaaatacat gtgaggtata gccaccactg ttttccttgc tgttattttt   1740

ccaagtcttg gggagaaaac atcctcctct gatggccaaa gccctggaat caagggtttc   1800

cacgtaccct gcctaatacc cgacgtagct cttgatgcac cgtccttgtg ctgtggctgg   1860

cggtgtctca gcctgaaaca taaaccccac atgccccagg agcgatgtgc tccctgaaac   1920

agacaaccac acgctgttgg ggagagaagg atggagatag gatggagata ggatggagat   1980

gtggctcttc tcatctttga agccagcagg gcatcccgga gcaggaggct ggccgggctc   2040

cccaagcgaa ggcgttggtg tctgtcatta ggtgtgtgtt agggtgcagc accggccgtc   2100

acaggatgct gataagcgcg ctgagaggtg gatgaaacac caaagtctgt ttccccgtcc   2160

gcagtgggtg ttgcctcttt gtgtgtgtcc cgatgttcct gcctgtgagt cggccttact   2220

ccgtttcctt agcgcccatg acacgccaag tcccgtttcg cactcggctt ctcacccgcc   2280

cagctcggct agggaggggg agtttttagc acctaatatg cttcctgcca ttgcgcaatc   2340

tgagcctgag caactggaaa cccccatttc tcattagtgc aatgtcatat ctgatcccag   2400

gaagcctgga aaataaaaga cgatgcatta taacttgcgg aagtacaaga              2450


<210>  2371
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  2371

Met Ile Leu Asn Leu Asp Thr Gly Val Lys Asp Asn Ile Tyr Arg Lys 
1               5                   10                  15


Pro Pro Ile Tyr Arg Gln His Ala Ala Arg Arg Ser Asp Gly Glu Asp 
            20                  25                  30


Gly Ser Leu Asp Gln Asp Asn Arg Lys Gln Lys Ser Ser Trp Leu Met 
        35                  40                  45


Leu Lys Gly Asp Ala Asp Thr Arg Thr Asn Ser Pro Asp Leu Asp Thr 
    50                  55                  60


Gln Ser Leu Ser His Ser Ser Gly Thr Asp Arg Asp Pro Leu Gln Arg 
65                  70                  75                  80


Met Ala Gly Asp Ser Phe His Ser Gln Tyr Lys Ile Tyr Pro Tyr Asp 
                85                  90                  95


Ser Leu Ile Val Thr Asn Arg Ile Arg Val Lys Leu Pro Lys Asp Val 
            100                 105                 110


Asp Arg Thr Arg Leu Glu Arg His Leu Ser Pro Glu Glu Phe Gln Glu 
        115                 120                 125


Val Phe Gly Met Ser Ile Glu Glu Phe Asp Arg Leu Ala Leu Trp Lys 
    130                 135                 140


Arg Asn Asp Leu Lys Lys Lys Ala Leu Leu Phe 
145                 150                 155


<210>  2372
<211>  2756
<212>  DNA
<213>  Homo sapiens

<400>  2372
ctactctttt cttatcttct gcagctggca aaattttact caatggcttt taaaggacaa     60

ttttgatcat tttagtgctt taatcctatt ctgagcagct aatttttaga ttctcaagga    120

aaacagcatg tttatataca aggataatta ggaagagggg cctttgtttt ggcgaatttg    180

cagttggttg gattcaaaca ccagccagga tgcagaggcg cagatggagt gagcccccta    240

aggtgttctt agttcaccgc ccagccctct gccctcagca atgtcgctcc tctgccttgg    300

gactctggac agacttcaac tcagggttgg attagcaagt ccttggacac agtctgggaa    360

cgtggatgag gcccacactc cttcccctgg gcaggggatc tgggctgctc caccagacag    420

gagagatggg gctcgctgca aataagcttt tcatgcttga aatattctac tttgctttcc    480

cgtttcccct tctatctgct gcctttgccc ttccgtctgg aggcagtgaa agtggccgga    540

gcacccccag cctctccgtg ctctctgaca gcaagccgcc cccctccacc taccagcagg    600

cacctcgcca cttccacgtc ccagacactg gcgtaaaaga taacatctat aggaaacccc    660

ctatctacag acagcatgct gccaggcgat cggatgggga ggatggaagc ttggaccagg    720

ataacaggaa gcagaagagc agctggctga tgctcaaggg ggatgcagac acaaggacca    780

attctccaga cctggacacc cagtccttgt cccacagcag cgggaccgac agagaccctc    840

tccaaaggat ggcaggggac agctttcact cacaatacaa gatctatccg tatgactccc    900

tcatcgtcac aaaccgaatt cgcgtgaaac tgcccaaaga cgtggaccgg acgagactgg    960

agagacactt gtcgcccgag gagttccagg aagtgtttgg gatgagcatc gaggagtttg   1020

accgcctggc cctctggaag aggaatgacc ttaagaagaa agcccttttg ttctgacggc   1080

tgccagcctg ccccactggt gtgtgccggg cgccgaggcc aggggcccct ggcgagaacc   1140

gcacacaccc ctcccacaca ccttgctctg gcttctctgt gtccatgggg tgggcgggag   1200

ggggtccccc agcaggtgcg gcccctgcac ctgccggcga cactcctgcc ggtagtttag   1260

ggccgagacg gctagcttca cgccaccctt ccccgctgtg gcttggtgtc agggagaggc   1320

tgtagagtgg ctgtgtcggg catcagatgg agcacacagg tggctgcagc ccagcccacc   1380

ttcccagcgt tctcgaggtg ccctggcccc ggtgctgggc acgtggggga cagaggtggc   1440

cgggacgtga gctgtgaggc ttgttgatga tggttgctga caccatcatc gggggtgggc   1500

acacggccct tcggagcctg ggcagcctgg cctcacaggc agactcgcag acggggcagt   1560

gagcgtctgg gacagtgcca agagtggggt gtgtgatttt tgcaggcgtc tgtgatgggt   1620

ctctttaggg acaaatgtca acaagggaca agacagggca ccttccgcca gcgcccctcc   1680

atgcgctgcg ttcctcctcc agatcgaccc ctagatgcct acacaatatc tttaaagtaa   1740

cacagaagtt tttattttat taaaaagtat agcctactta aacgcgagat gacatatata   1800

gagtttaatt ttacggtccc tccgcagggg agcggcctcc agccttattc tccaccgctc   1860

ggatctgtgt ggtttcagtc tgttcttggt gtggtcctca tacacagagc tccctgtcta   1920

gtttcttttc tttttctttt ttctttttct cgtcacacag gtaaccttaa agacagaccc   1980

ctctaaagaa cgctttgtaa atacatgtga ggtatagcca ccactgtttt ccttgctgtt   2040

atttttccaa gtcttgggga gaaaacatcc tcctctgatg gccaaagccc tggaatcaag   2100

ggtttccacg taccctgcct aatacccgac gtagctcttg atgcaccgtc cttgtgctgt   2160

ggctggcggt gtctcagcct gaaacataaa ccccacatgc cccaggagcg atgtgctccc   2220

tgaaacagac aaccacacgc tgttggggag agaaggatgg agataggatg gagataggat   2280

ggagatgtgg ctcttctcat ctttgaagcc agcagggcat cccggagcag gaggctggcc   2340

gggctcccca agcgaaggcg ttggtgtctg tcattaggtg tgtgttaggg tgcagcaccg   2400

gccgtcacag gatgctgata agcgcgctga gaggtggatg aaacaccaaa gtctgtttcc   2460

ccgtccgcag tgggtgttgc ctctttgtgt gtgtcccgat gttcctgcct gtgagtcggc   2520

cttactccgt ttccttagcg cccatgacac gccaagtccc gtttcgcact cggcttctca   2580

cccgcccagc tcggctaggg agggggagtt tttagcacct aatatgcttc ctgccattgc   2640

gcaatctgag cctgagcaac tggaaacccc catttctcat tagtgcaatg tcatatctga   2700

tcccaggaag cctggaaaat aaaagacgat gcattataac ttgcggaagt acaaga       2756


<210>  2373
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  2373

Met Arg Pro Thr Leu Leu Pro Leu Gly Arg Gly Ser Gly Leu Leu His 
1               5                   10                  15


Gln Thr Gly Glu Met Gly Leu Ala Ala Asn Lys Leu Phe Met Leu Glu 
            20                  25                  30


Ile Phe Tyr Phe Ala Phe Pro Phe Pro Leu Leu Ser Ala Ala Phe Ala 
        35                  40                  45


Leu Pro Ser Gly Gly Ser Glu Ser Gly Arg Ser Thr Pro Ser Leu Ser 
    50                  55                  60


Val Leu Ser Asp Ser Lys Pro Pro Pro Ser Thr Tyr Gln Gln Ala Pro 
65                  70                  75                  80


Arg His Phe His Val Pro Asp Thr Gly Val Lys Asp Asn Ile Tyr Arg 
                85                  90                  95


Lys Pro Pro Ile Tyr Arg Gln His Ala Ala Arg Arg Ser Asp Gly Glu 
            100                 105                 110


Asp Gly Ser Leu Asp Gln Asp Asn Arg Lys Gln Lys Ser Ser Trp Leu 
        115                 120                 125


Met Leu Lys Gly Asp Ala Asp Thr Arg Thr Asn Ser Pro Asp Leu Asp 
    130                 135                 140


Thr Gln Ser Leu Ser His Ser Ser Gly Thr Asp Arg Asp Pro Leu Gln 
145                 150                 155                 160


Arg Met Ala Gly Asp Ser Phe His Ser Gln Tyr Lys Ile Tyr Pro Tyr 
                165                 170                 175


Asp Ser Leu Ile Val Thr Asn Arg Ile Arg Val Lys Leu Pro Lys Asp 
            180                 185                 190


Val Asp Arg Thr Arg Leu Glu Arg His Leu Ser Pro Glu Glu Phe Gln 
        195                 200                 205


Glu Val Phe Gly Met Ser Ile Glu Glu Phe Asp Arg Leu Ala Leu Trp 
    210                 215                 220


Lys Arg Asn Asp Leu Lys Lys Lys Ala Leu Leu Phe 
225                 230                 235


<210>  2374
<211>  3172
<212>  DNA
<213>  Homo sapiens

<400>  2374
cctcctcctc tgctgtggag gagaaagggc ctcctgggga agattaatgc ttttgttttc     60

gcctctgccg gggaggcgag tctgtggcgg cgtggctgag tcggcgggct ctgcacagct    120

ctgagcatcc tccccgggtg caaggtggga actgcgggcg gggacaagcc tggctccgca    180

gaaggggagc tgccgccgcc gcggtggcac tgcctgatgc tcggcccagt gtgccggtgc    240

cccgctgggt gacagtggac tcccagggcg cagcaggagc aggtgacaga ctgttggctg    300

aaggtgaggg tgtccaccct cgcaggcaca cgttccaggg agcacggcac tcaagcaggg    360

ccgtcagact gggctctggt gcccagaagc tgtgcaggcc ggagagaagc actaccaccc    420

ttcctgcgcg ctatgtgtca ggtgcggcca gatgtttgca gaaggcgaag agatgtatct    480

tcaaggttcc tccatctggc atccggcgtg tcgacaagca gccagaactg aagacagaaa    540

caaggaaacc agaacttcct cagagagcat catttctgtc cctgcttcca gcacctcagg    600

gtctccgagc cgtgtgattt atgccaagct tggtggtgag atcctggact acagggactt    660

ggcagccctt cctaaaagta aggccatcta tgacatcgac cgccccgaca tgatctccta    720

ctcaccctac atcagccact ctgcagggga caggcagagc tacggcgagt cccctcagtt    780

gctctcgcca acgccgaccg agggggatca ggatgaccgg tcctacaagc agtgtcggac    840

ctccagccca agctccactg ggtcggttag cctcgggcgc tacactccga cctcacggtc    900

accacagcac tacagccgtc cagacactgg cgtaaaagat aacatctata ggaaaccccc    960

tatctacaga cagcatgctg ccaggcgatc ggatggggag gatggaagct tggaccagga   1020

taacaggaag cagaagagca gctggctgat gctcaagggg gatgcagaca caaggaccaa   1080

ttctccagac ctggacaccc agtccttgtc ccacagcagc gggaccgaca gagaccctct   1140

ccaaaggatg gcaggggaca gctttcactc acgattcccc tattccaaat ctgaccctct   1200

cccaggacat ggaaagaatg gcttggacca gcggaatgcc aatctggccc cctgtggagc   1260

agacccggat gccagctggg gcatgcgaga atacaagatc tatccgtatg actccctcat   1320

cgtcacaaac cgaattcgcg tgaaactgcc caaagacgtg gaccggacga gactggagag   1380

acacttgtcg cccgaggagt tccaggaagt gtttgggatg agcatcgagg agtttgaccg   1440

cctggccctc tggaagagga atgaccttaa gaagaaagcc cttttgttct gacggctgcc   1500

agcctgcccc actggtgtgt gccgggcgcc gaggccaggg gcccctggcg agaaccgcac   1560

acacccctcc cacacacctt gctctggctt ctctgtgtcc atggggtggg cgggaggggg   1620

tcccccagca ggtgcggccc ctgcacctgc cggcgacact cctgccggta gtttagggcc   1680

gagacggcta gcttcacgcc acccttcccc gctgtggctt ggtgtcaggg agaggctgta   1740

gagtggctgt gtcgggcatc agatggagca cacaggtggc tgcagcccag cccaccttcc   1800

cagcgttctc gaggtgccct ggccccggtg ctgggcacgt gggggacaga ggtggccggg   1860

acgtgagctg tgaggcttgt tgatgatggt tgctgacacc atcatcgggg gtgggcacac   1920

ggcccttcgg agcctgggca gcctggcctc acaggcagac tcgcagacgg ggcagtgagc   1980

gtctgggaca gtgccaagag tggggtgtgt gatttttgca ggcgtctgtg atgggtctct   2040

ttagggacaa atgtcaacaa gggacaagac agggcacctt ccgccagcgc ccctccatgc   2100

gctgcgttcc tcctccagat cgacccctag atgcctacac aatatcttta aagtaacaca   2160

gaagttttta ttttattaaa aagtatagcc tacttaaacg cgagatgaca tatatagagt   2220

ttaattttac ggtccctccg caggggagcg gcctccagcc ttattctcca ccgctcggat   2280

ctgtgtggtt tcagtctgtt cttggtgtgg tcctcataca cagagctccc tgtctagttt   2340

cttttctttt tcttttttct ttttctcgtc acacaggtaa ccttaaagac agacccctct   2400

aaagaacgct ttgtaaatac atgtgaggta tagccaccac tgttttcctt gctgttattt   2460

ttccaagtct tggggagaaa acatcctcct ctgatggcca aagccctgga atcaagggtt   2520

tccacgtacc ctgcctaata cccgacgtag ctcttgatgc accgtccttg tgctgtggct   2580

ggcggtgtct cagcctgaaa cataaacccc acatgcccca ggagcgatgt gctccctgaa   2640

acagacaacc acacgctgtt ggggagagaa ggatggagat aggatggaga taggatggag   2700

atgtggctct tctcatcttt gaagccagca gggcatcccg gagcaggagg ctggccgggc   2760

tccccaagcg aaggcgttgg tgtctgtcat taggtgtgtg ttagggtgca gcaccggccg   2820

tcacaggatg ctgataagcg cgctgagagg tggatgaaac accaaagtct gtttccccgt   2880

ccgcagtggg tgttgcctct ttgtgtgtgt cccgatgttc ctgcctgtga gtcggcctta   2940

ctccgtttcc ttagcgccca tgacacgcca agtcccgttt cgcactcggc ttctcacccg   3000

cccagctcgg ctagggaggg ggagttttta gcacctaata tgcttcctgc cattgcgcaa   3060

tctgagcctg agcaactgga aacccccatt tctcattagt gcaatgtcat atctgatccc   3120

aggaagcctg gaaaataaaa gacgatgcat tataacttgc ggaagtacaa ga           3172


<210>  2375
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  2375

Met Phe Ala Glu Gly Glu Glu Met Tyr Leu Gln Gly Ser Ser Ile Trp 
1               5                   10                  15


His Pro Ala Cys Arg Gln Ala Ala Arg Thr Glu Asp Arg Asn Lys Glu 
            20                  25                  30


Thr Arg Thr Ser Ser Glu Ser Ile Ile Ser Val Pro Ala Ser Ser Thr 
        35                  40                  45


Ser Gly Ser Pro Ser Arg Val Ile Tyr Ala Lys Leu Gly Gly Glu Ile 
    50                  55                  60


Leu Asp Tyr Arg Asp Leu Ala Ala Leu Pro Lys Ser Lys Ala Ile Tyr 
65                  70                  75                  80


Asp Ile Asp Arg Pro Asp Met Ile Ser Tyr Ser Pro Tyr Ile Ser His 
                85                  90                  95


Ser Ala Gly Asp Arg Gln Ser Tyr Gly Glu Ser Pro Gln Leu Leu Ser 
            100                 105                 110


Pro Thr Pro Thr Glu Gly Asp Gln Asp Asp Arg Ser Tyr Lys Gln Cys 
        115                 120                 125


Arg Thr Ser Ser Pro Ser Ser Thr Gly Ser Val Ser Leu Gly Arg Tyr 
    130                 135                 140


Thr Pro Thr Ser Arg Ser Pro Gln His Tyr Ser Arg Pro Asp Thr Gly 
145                 150                 155                 160


Val Lys Asp Asn Ile Tyr Arg Lys Pro Pro Ile Tyr Arg Gln His Ala 
                165                 170                 175


Ala Arg Arg Ser Asp Gly Glu Asp Gly Ser Leu Asp Gln Asp Asn Arg 
            180                 185                 190


Lys Gln Lys Ser Ser Trp Leu Met Leu Lys Gly Asp Ala Asp Thr Arg 
        195                 200                 205


Thr Asn Ser Pro Asp Leu Asp Thr Gln Ser Leu Ser His Ser Ser Gly 
    210                 215                 220


Thr Asp Arg Asp Pro Leu Gln Arg Met Ala Gly Asp Ser Phe His Ser 
225                 230                 235                 240


Arg Phe Pro Tyr Ser Lys Ser Asp Pro Leu Pro Gly His Gly Lys Asn 
                245                 250                 255


Gly Leu Asp Gln Arg Asn Ala Asn Leu Ala Pro Cys Gly Ala Asp Pro 
            260                 265                 270


Asp Ala Ser Trp Gly Met Arg Glu Tyr Lys Ile Tyr Pro Tyr Asp Ser 
        275                 280                 285


Leu Ile Val Thr Asn Arg Ile Arg Val Lys Leu Pro Lys Asp Val Asp 
    290                 295                 300


Arg Thr Arg Leu Glu Arg His Leu Ser Pro Glu Glu Phe Gln Glu Val 
305                 310                 315                 320


Phe Gly Met Ser Ile Glu Glu Phe Asp Arg Leu Ala Leu Trp Lys Arg 
                325                 330                 335


Asn Asp Leu Lys Lys Lys Ala Leu Leu Phe 
            340                 345


<210>  2376
<211>  490
<212>  DNA
<213>  Homo sapiens

<400>  2376
agcatgtggc tgcgacctgg ccgagggcgg cttcttcgtg cggcagggcg agtacatctg     60

cacgctggat ggccgggctc cccaagcgaa ggcgttggtg tctgtcatta ggtgtgtgtt    120

agggtgcagc accggccgtc acaggatgct gataagcgcg ctgagaggtg gatgaaacac    180

caaagtctgt ttccccgtcc gcagtgggtg ttgcctcttt gtgtgtgtcc cgatgttcct    240

gcctgtgagt cggccttact ccgtttcctt agcgcccatg acacgccaag tcccgtttcg    300

cactcggctt ctcacccgcc cagctcggct agggaggggg agtttttagc acctaatatg    360

cttcctgcca ttgcgcaatc tgagcctgag caactggaaa cccccatttc tcattagtgc    420

aatgtcatat ctgatcccag gaagcctgga aaataaaaga cgatgcatta taacttgcgg    480

aagtacaaga                                                           490


<210>  2377
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  2377

Met Trp Leu Arg Pro Gly Arg Gly Arg Leu Leu Arg Ala Ala Gly Arg 
1               5                   10                  15


Val His Leu His Ala Gly Trp Pro Gly Ser Pro Ser Glu Gly Val Gly 
            20                  25                  30


Val Cys His 
        35


<210>  2378
<211>  3545
<212>  DNA
<213>  Homo sapiens

<400>  2378
tgcggcggcg ctgcctggcg tgtgcgcaag gagcgggcgc ggagccggcg ggcgggcgga     60

ggatagcgcg ggcgcggcac ctgcgggccc gagggtctgg ctgtcgcagc gccgggccgc    120

cccgactccg agcggctgct gagatgagtg cagtgtcgca gccccaggct gctcccagcc    180

cgctggagaa gtcgcccagc acggcgatcc tgtgcaacac gtgtgggaat gtgtgcaagg    240

gcgaggtgct gcgggtgcag gacaagtact tccacatcaa gtgcttcgtc tgtaaagcat    300

gtggctgcga cctggccgag ggcggcttct tcgtgcggca gggcgagtac atctgcacgc    360

tggactacca gaggctctac ggcacccgct gcttcagctg cgaccagttc attgagggtg    420

aggtggtgtc ggcgctgggc aagacctacc accccgactg cttcgtgtgt gccgtctgcc    480

ggctgccctt cccccccggg gaccgagtga ccttcaacgg gaaggaatgc atgtgccaga    540

agtgttccct gcccgtatcg gtgggcagca gcgcgcacct gtcccagggc ctccgaagtt    600

gtgggggctg cggcacagaa atcaagaatg gccaggccct ggtagccttg gacaagcact    660

ggcacttggg ctgttttaag tgcaagagct gtgggaagct cctgaatgcc gagtacatca    720

gcaaggatgg gctgccctac tgcgaagctg actatcacgc caagttcggc atccgctgtg    780

acagctgtga gaaatacatc acggggcgcg tgctggaggc cggagagaag cactaccacc    840

cttcctgcgc gctatgtgtc aggtgcggcc agatgtttgc agaaggcgaa gagatgtatc    900

ttcaaggttc ctccatctgg catccggcgt gtcgacaagc agccagaact gaagacagaa    960

acaaggaaac cagaacttcc tcagagagca tcatttctgt ccctgcttcc agcacctcag   1020

ggtctccgag ccgtgtgatt tatgccaagc ttggtggtga gatcctggac tacagggact   1080

tggcagccct tcctaaaagt aaggccatct atgacatcga ccgccccgac atgatctcct   1140

actcacccta catcagccac tctgcagggg acaggcagag ctacggcgag ggggatcagg   1200

atgaccggtc ctacaagcag tgtcggacct ccagcccaag ctccactggg tcggttagcc   1260

tcgggcgcta cactccgacc tcacggtcac cacagcacta cagccgtcca ggcagtgaaa   1320

gtggccggag cacccccagc ctctccgtgc tctctgacag caagccgccc ccctccacct   1380

accagcaggc acctcgccac ttccacgtcc cagacactgg cgtaaaagat aacatctata   1440

ggaaaccccc tatctacaga cagcatgctg ccaggcgatc ggatggggag gatggaagct   1500

tggaccagga taacaggaag cagaagagca gctggctgat gctcaagggg gatgcagaca   1560

caaggaccaa ttctccagac ctggacaccc agtccttgtc ccacagcagc gggaccgaca   1620

gagaccctct ccaaaggatg gcaggggaca gctttcactc acaatacaag atctatccgt   1680

atgactccct catcgtcaca aaccgaattc gcgtgaaact gcccaaagac gtggaccgga   1740

cgagactgga gagacacttg tcgcccgagg agttccagga agtgtttggg atgagcatcg   1800

aggagtttga ccgcctggcc ctctggaaga ggaatgacct taagaagaaa gcccttttgt   1860

tctgacggct gccagcctgc cccactggtg tgtgccgggc gccgaggcca ggggcccctg   1920

gcgagaaccg cacacacccc tcccacacac cttgctctgg cttctctgtg tccatggggt   1980

gggcgggagg gggtccccca gcaggtgcgg cccctgcacc tgccggcgac actcctgccg   2040

gtagtttagg gccgagacgg ctagcttcac gccacccttc cccgctgtgg cttggtgtca   2100

gggagaggct gtagagtggc tgtgtcgggc atcagatgga gcacacaggt ggctgcagcc   2160

cagcccacct tcccagcgtt ctcgaggtgc cctggccccg gtgctgggca cgtgggggac   2220

agaggtggcc gggacgtgag ctgtgaggct tgttgatgat ggttgctgac accatcatcg   2280

ggggtgggca cacggccctt cggagcctgg gcagcctggc ctcacaggca gactcgcaga   2340

cggggcagtg agcgtctggg acagtgccaa gagtggggtg tgtgattttt gcaggcgtct   2400

gtgatgggtc tctttaggga caaatgtcaa caagggacaa gacagggcac cttccgccag   2460

cgcccctcca tgcgctgcgt tcctcctcca gatcgacccc tagatgccta cacaatatct   2520

ttaaagtaac acagaagttt ttattttatt aaaaagtata gcctacttaa acgcgagatg   2580

acatatatag agtttaattt tacggtccct ccgcagggga gcggcctcca gccttattct   2640

ccaccgctcg gatctgtgtg gtttcagtct gttcttggtg tggtcctcat acacagagct   2700

ccctgtctag tttcttttct ttttcttttt tctttttctc gtcacacagg taaccttaaa   2760

gacagacccc tctaaagaac gctttgtaaa tacatgtgag gtatagccac cactgttttc   2820

cttgctgtta tttttccaag tcttggggag aaaacatcct cctctgatgg ccaaagccct   2880

ggaatcaagg gtttccacgt accctgccta atacccgacg tagctcttga tgcaccgtcc   2940

ttgtgctgtg gctggcggtg tctcagcctg aaacataaac cccacatgcc ccaggagcga   3000

tgtgctccct gaaacagaca accacacgct gttggggaga gaaggatgga gataggatgg   3060

agataggatg gagatgtggc tcttctcatc tttgaagcca gcagggcatc ccggagcagg   3120

aggctggccg ggctccccaa gcgaaggcgt tggtgtctgt cattaggtgt gtgttagggt   3180

gcagcaccgg ccgtcacagg atgctgataa gcgcgctgag aggtggatga aacaccaaag   3240

tctgtttccc cgtccgcagt gggtgttgcc tctttgtgtg tgtcccgatg ttcctgcctg   3300

tgagtcggcc ttactccgtt tccttagcgc ccatgacacg ccaagtcccg tttcgcactc   3360

ggcttctcac ccgcccagct cggctaggga gggggagttt ttagcaccta atatgcttcc   3420

tgccattgcg caatctgagc ctgagcaact ggaaaccccc atttctcatt agtgcaatgt   3480

catatctgat cccaggaagc ctggaaaata aaagacgatg cattataact tgcggaagta   3540

caaga                                                               3545


<210>  2379
<211>  573
<212>  PRT
<213>  Homo sapiens

<400>  2379

Met Ser Ala Val Ser Gln Pro Gln Ala Ala Pro Ser Pro Leu Glu Lys 
1               5                   10                  15


Ser Pro Ser Thr Ala Ile Leu Cys Asn Thr Cys Gly Asn Val Cys Lys 
            20                  25                  30


Gly Glu Val Leu Arg Val Gln Asp Lys Tyr Phe His Ile Lys Cys Phe 
        35                  40                  45


Val Cys Lys Ala Cys Gly Cys Asp Leu Ala Glu Gly Gly Phe Phe Val 
    50                  55                  60


Arg Gln Gly Glu Tyr Ile Cys Thr Leu Asp Tyr Gln Arg Leu Tyr Gly 
65                  70                  75                  80


Thr Arg Cys Phe Ser Cys Asp Gln Phe Ile Glu Gly Glu Val Val Ser 
                85                  90                  95


Ala Leu Gly Lys Thr Tyr His Pro Asp Cys Phe Val Cys Ala Val Cys 
            100                 105                 110


Arg Leu Pro Phe Pro Pro Gly Asp Arg Val Thr Phe Asn Gly Lys Glu 
        115                 120                 125


Cys Met Cys Gln Lys Cys Ser Leu Pro Val Ser Val Gly Ser Ser Ala 
    130                 135                 140


His Leu Ser Gln Gly Leu Arg Ser Cys Gly Gly Cys Gly Thr Glu Ile 
145                 150                 155                 160


Lys Asn Gly Gln Ala Leu Val Ala Leu Asp Lys His Trp His Leu Gly 
                165                 170                 175


Cys Phe Lys Cys Lys Ser Cys Gly Lys Leu Leu Asn Ala Glu Tyr Ile 
            180                 185                 190


Ser Lys Asp Gly Leu Pro Tyr Cys Glu Ala Asp Tyr His Ala Lys Phe 
        195                 200                 205


Gly Ile Arg Cys Asp Ser Cys Glu Lys Tyr Ile Thr Gly Arg Val Leu 
    210                 215                 220


Glu Ala Gly Glu Lys His Tyr His Pro Ser Cys Ala Leu Cys Val Arg 
225                 230                 235                 240


Cys Gly Gln Met Phe Ala Glu Gly Glu Glu Met Tyr Leu Gln Gly Ser 
                245                 250                 255


Ser Ile Trp His Pro Ala Cys Arg Gln Ala Ala Arg Thr Glu Asp Arg 
            260                 265                 270


Asn Lys Glu Thr Arg Thr Ser Ser Glu Ser Ile Ile Ser Val Pro Ala 
        275                 280                 285


Ser Ser Thr Ser Gly Ser Pro Ser Arg Val Ile Tyr Ala Lys Leu Gly 
    290                 295                 300


Gly Glu Ile Leu Asp Tyr Arg Asp Leu Ala Ala Leu Pro Lys Ser Lys 
305                 310                 315                 320


Ala Ile Tyr Asp Ile Asp Arg Pro Asp Met Ile Ser Tyr Ser Pro Tyr 
                325                 330                 335


Ile Ser His Ser Ala Gly Asp Arg Gln Ser Tyr Gly Glu Gly Asp Gln 
            340                 345                 350


Asp Asp Arg Ser Tyr Lys Gln Cys Arg Thr Ser Ser Pro Ser Ser Thr 
        355                 360                 365


Gly Ser Val Ser Leu Gly Arg Tyr Thr Pro Thr Ser Arg Ser Pro Gln 
    370                 375                 380


His Tyr Ser Arg Pro Gly Ser Glu Ser Gly Arg Ser Thr Pro Ser Leu 
385                 390                 395                 400


Ser Val Leu Ser Asp Ser Lys Pro Pro Pro Ser Thr Tyr Gln Gln Ala 
                405                 410                 415


Pro Arg His Phe His Val Pro Asp Thr Gly Val Lys Asp Asn Ile Tyr 
            420                 425                 430


Arg Lys Pro Pro Ile Tyr Arg Gln His Ala Ala Arg Arg Ser Asp Gly 
        435                 440                 445


Glu Asp Gly Ser Leu Asp Gln Asp Asn Arg Lys Gln Lys Ser Ser Trp 
    450                 455                 460


Leu Met Leu Lys Gly Asp Ala Asp Thr Arg Thr Asn Ser Pro Asp Leu 
465                 470                 475                 480


Asp Thr Gln Ser Leu Ser His Ser Ser Gly Thr Asp Arg Asp Pro Leu 
                485                 490                 495


Gln Arg Met Ala Gly Asp Ser Phe His Ser Gln Tyr Lys Ile Tyr Pro 
            500                 505                 510


Tyr Asp Ser Leu Ile Val Thr Asn Arg Ile Arg Val Lys Leu Pro Lys 
        515                 520                 525


Asp Val Asp Arg Thr Arg Leu Glu Arg His Leu Ser Pro Glu Glu Phe 
    530                 535                 540


Gln Glu Val Phe Gly Met Ser Ile Glu Glu Phe Asp Arg Leu Ala Leu 
545                 550                 555                 560


Trp Lys Arg Asn Asp Leu Lys Lys Lys Ala Leu Leu Phe 
                565                 570


<210>  2380
<211>  3662
<212>  DNA
<213>  Homo sapiens

<400>  2380
tgcggcggcg ctgcctggcg tgtgcgcaag gagcgggcgc ggagccggcg ggcgggcgga     60

ggatagcgcg ggcgcggcac ctgcgggccc gagggtctgg ctgtcgcagc gccgggccgc    120

cccgactccg agcggctgct gagatgagtg cagtgtcgca gccccaggct gctcccagcc    180

cgctggagaa gtcgcccagc acggcgatcc tgtgcaacac gtgtgggaat gtgtgcaagg    240

gcgaggtgct gcgggtgcag gacaagtact tccacatcaa gtgcttcgtc tgtaaagcat    300

gtggctgcga cctggccgag ggcggcttct tcgtgcggca gggcgagtac atctgcacgc    360

tggactacca gaggctctac ggcacccgct gcttcagctg cgaccagttc attgagggtg    420

aggtggtgtc ggcgctgggc aagacctacc accccgactg cttcgtgtgt gccgtctgcc    480

ggctgccctt cccccccggg gaccgagtga ccttcaacgg gaaggaatgc atgtgccaga    540

agtgttccct gcccgtatcg gtgggcagca gcgcgcacct gtcccagggc ctccgaagtt    600

gtgggggctg cggcacagaa atcaagaatg gccaggccct ggtagccttg gacaagcact    660

ggcacttggg ctgttttaag tgcaagagct gtgggaagct cctgaatgcc gagtacatca    720

gcaaggatgg gctgccctac tgcgaagctg actatcacgc caagttcggc atccgctgtg    780

acagctgtga gaaatacatc acggggcgcg tgctggaggc cggagagaag cactaccacc    840

cttcctgcgc gctatgtgtc aggtgcggcc agatgtttgc agaaggcgaa gagatgtatc    900

ttcaaggttc ctccatctgg catccggcgt gtcgacaagc agccagaact gaagacagaa    960

acaaggaaac cagaacttcc tcagagagca tcatttctgt ccctgcttcc agcacctcag   1020

ggtctccgag ccgtgtgatt tatgccaagc ttggtggtga gatcctggac tacagggact   1080

tggcagccct tcctaaaagt aaggccatct atgacatcga ccgccccgac atgatctcct   1140

actcacccta catcagccac tctgcagggg acaggcagag ctacggcgag ggggatcagg   1200

atgaccggtc ctacaagcag tgtcggacct ccagcccaag ctccactggg tcggttagcc   1260

tcgggcgcta cactccgacc tcacggtcac cacagcacta cagccgtcca ggcagtgaaa   1320

gtggccggag cacccccagc ctctccgtgc tctctgacag caagccgccc ccctccacct   1380

accagcaggc acctcgccac ttccacgtcc cagacactgg cgtaaaagat aacatctata   1440

ggaaaccccc tatctacaga cagcatgctg ccaggcgatc ggatggggag gatggaagct   1500

tggaccagga taacaggaag cagaagagca gctggctgat gctcaagggg gatgcagaca   1560

caaggaccaa ttctccagac ctggacaccc agtccttgtc ccacagcagc gggaccgaca   1620

gagaccctct ccaaaggatg gcaggggaca gctttcactc acgattcccc tattccaaat   1680

ctgaccctct cccaggacat ggaaagaatg gcttggacca gcggaatgcc aatctggccc   1740

cctgtggagc agacccggat gccagctggg gcatgcgaga atacaagatc tatccgtatg   1800

actccctcat cgtcacaaac cgaattcgcg tgaaactgcc caaagacgtg gaccggacga   1860

gactggagag acacttgtcg cccgaggagt tccaggaagt gtttgggatg agcatcgagg   1920

agtttgaccg cctggccctc tggaagagga atgaccttaa gaagaaagcc cttttgttct   1980

gacggctgcc agcctgcccc actggtgtgt gccgggcgcc gaggccaggg gcccctggcg   2040

agaaccgcac acacccctcc cacacacctt gctctggctt ctctgtgtcc atggggtggg   2100

cgggaggggg tcccccagca ggtgcggccc ctgcacctgc cggcgacact cctgccggta   2160

gtttagggcc gagacggcta gcttcacgcc acccttcccc gctgtggctt ggtgtcaggg   2220

agaggctgta gagtggctgt gtcgggcatc agatggagca cacaggtggc tgcagcccag   2280

cccaccttcc cagcgttctc gaggtgccct ggccccggtg ctgggcacgt gggggacaga   2340

ggtggccggg acgtgagctg tgaggcttgt tgatgatggt tgctgacacc atcatcgggg   2400

gtgggcacac ggcccttcgg agcctgggca gcctggcctc acaggcagac tcgcagacgg   2460

ggcagtgagc gtctgggaca gtgccaagag tggggtgtgt gatttttgca ggcgtctgtg   2520

atgggtctct ttagggacaa atgtcaacaa gggacaagac agggcacctt ccgccagcgc   2580

ccctccatgc gctgcgttcc tcctccagat cgacccctag atgcctacac aatatcttta   2640

aagtaacaca gaagttttta ttttattaaa aagtatagcc tacttaaacg cgagatgaca   2700

tatatagagt ttaattttac ggtccctccg caggggagcg gcctccagcc ttattctcca   2760

ccgctcggat ctgtgtggtt tcagtctgtt cttggtgtgg tcctcataca cagagctccc   2820

tgtctagttt cttttctttt tcttttttct ttttctcgtc acacaggtaa ccttaaagac   2880

agacccctct aaagaacgct ttgtaaatac atgtgaggta tagccaccac tgttttcctt   2940

gctgttattt ttccaagtct tggggagaaa acatcctcct ctgatggcca aagccctgga   3000

atcaagggtt tccacgtacc ctgcctaata cccgacgtag ctcttgatgc accgtccttg   3060

tgctgtggct ggcggtgtct cagcctgaaa cataaacccc acatgcccca ggagcgatgt   3120

gctccctgaa acagacaacc acacgctgtt ggggagagaa ggatggagat aggatggaga   3180

taggatggag atgtggctct tctcatcttt gaagccagca gggcatcccg gagcaggagg   3240

ctggccgggc tccccaagcg aaggcgttgg tgtctgtcat taggtgtgtg ttagggtgca   3300

gcaccggccg tcacaggatg ctgataagcg cgctgagagg tggatgaaac accaaagtct   3360

gtttccccgt ccgcagtggg tgttgcctct ttgtgtgtgt cccgatgttc ctgcctgtga   3420

gtcggcctta ctccgtttcc ttagcgccca tgacacgcca agtcccgttt cgcactcggc   3480

ttctcacccg cccagctcgg ctagggaggg ggagttttta gcacctaata tgcttcctgc   3540

cattgcgcaa tctgagcctg agcaactgga aacccccatt tctcattagt gcaatgtcat   3600

atctgatccc aggaagcctg gaaaataaaa gacgatgcat tataacttgc ggaagtacaa   3660

ga                                                                  3662


<210>  2381
<211>  612
<212>  PRT
<213>  Homo sapiens

<400>  2381

Met Ser Ala Val Ser Gln Pro Gln Ala Ala Pro Ser Pro Leu Glu Lys 
1               5                   10                  15


Ser Pro Ser Thr Ala Ile Leu Cys Asn Thr Cys Gly Asn Val Cys Lys 
            20                  25                  30


Gly Glu Val Leu Arg Val Gln Asp Lys Tyr Phe His Ile Lys Cys Phe 
        35                  40                  45


Val Cys Lys Ala Cys Gly Cys Asp Leu Ala Glu Gly Gly Phe Phe Val 
    50                  55                  60


Arg Gln Gly Glu Tyr Ile Cys Thr Leu Asp Tyr Gln Arg Leu Tyr Gly 
65                  70                  75                  80


Thr Arg Cys Phe Ser Cys Asp Gln Phe Ile Glu Gly Glu Val Val Ser 
                85                  90                  95


Ala Leu Gly Lys Thr Tyr His Pro Asp Cys Phe Val Cys Ala Val Cys 
            100                 105                 110


Arg Leu Pro Phe Pro Pro Gly Asp Arg Val Thr Phe Asn Gly Lys Glu 
        115                 120                 125


Cys Met Cys Gln Lys Cys Ser Leu Pro Val Ser Val Gly Ser Ser Ala 
    130                 135                 140


His Leu Ser Gln Gly Leu Arg Ser Cys Gly Gly Cys Gly Thr Glu Ile 
145                 150                 155                 160


Lys Asn Gly Gln Ala Leu Val Ala Leu Asp Lys His Trp His Leu Gly 
                165                 170                 175


Cys Phe Lys Cys Lys Ser Cys Gly Lys Leu Leu Asn Ala Glu Tyr Ile 
            180                 185                 190


Ser Lys Asp Gly Leu Pro Tyr Cys Glu Ala Asp Tyr His Ala Lys Phe 
        195                 200                 205


Gly Ile Arg Cys Asp Ser Cys Glu Lys Tyr Ile Thr Gly Arg Val Leu 
    210                 215                 220


Glu Ala Gly Glu Lys His Tyr His Pro Ser Cys Ala Leu Cys Val Arg 
225                 230                 235                 240


Cys Gly Gln Met Phe Ala Glu Gly Glu Glu Met Tyr Leu Gln Gly Ser 
                245                 250                 255


Ser Ile Trp His Pro Ala Cys Arg Gln Ala Ala Arg Thr Glu Asp Arg 
            260                 265                 270


Asn Lys Glu Thr Arg Thr Ser Ser Glu Ser Ile Ile Ser Val Pro Ala 
        275                 280                 285


Ser Ser Thr Ser Gly Ser Pro Ser Arg Val Ile Tyr Ala Lys Leu Gly 
    290                 295                 300


Gly Glu Ile Leu Asp Tyr Arg Asp Leu Ala Ala Leu Pro Lys Ser Lys 
305                 310                 315                 320


Ala Ile Tyr Asp Ile Asp Arg Pro Asp Met Ile Ser Tyr Ser Pro Tyr 
                325                 330                 335


Ile Ser His Ser Ala Gly Asp Arg Gln Ser Tyr Gly Glu Gly Asp Gln 
            340                 345                 350


Asp Asp Arg Ser Tyr Lys Gln Cys Arg Thr Ser Ser Pro Ser Ser Thr 
        355                 360                 365


Gly Ser Val Ser Leu Gly Arg Tyr Thr Pro Thr Ser Arg Ser Pro Gln 
    370                 375                 380


His Tyr Ser Arg Pro Gly Ser Glu Ser Gly Arg Ser Thr Pro Ser Leu 
385                 390                 395                 400


Ser Val Leu Ser Asp Ser Lys Pro Pro Pro Ser Thr Tyr Gln Gln Ala 
                405                 410                 415


Pro Arg His Phe His Val Pro Asp Thr Gly Val Lys Asp Asn Ile Tyr 
            420                 425                 430


Arg Lys Pro Pro Ile Tyr Arg Gln His Ala Ala Arg Arg Ser Asp Gly 
        435                 440                 445


Glu Asp Gly Ser Leu Asp Gln Asp Asn Arg Lys Gln Lys Ser Ser Trp 
    450                 455                 460


Leu Met Leu Lys Gly Asp Ala Asp Thr Arg Thr Asn Ser Pro Asp Leu 
465                 470                 475                 480


Asp Thr Gln Ser Leu Ser His Ser Ser Gly Thr Asp Arg Asp Pro Leu 
                485                 490                 495


Gln Arg Met Ala Gly Asp Ser Phe His Ser Arg Phe Pro Tyr Ser Lys 
            500                 505                 510


Ser Asp Pro Leu Pro Gly His Gly Lys Asn Gly Leu Asp Gln Arg Asn 
        515                 520                 525


Ala Asn Leu Ala Pro Cys Gly Ala Asp Pro Asp Ala Ser Trp Gly Met 
    530                 535                 540


Arg Glu Tyr Lys Ile Tyr Pro Tyr Asp Ser Leu Ile Val Thr Asn Arg 
545                 550                 555                 560


Ile Arg Val Lys Leu Pro Lys Asp Val Asp Arg Thr Arg Leu Glu Arg 
                565                 570                 575


His Leu Ser Pro Glu Glu Phe Gln Glu Val Phe Gly Met Ser Ile Glu 
            580                 585                 590


Glu Phe Asp Arg Leu Ala Leu Trp Lys Arg Asn Asp Leu Lys Lys Lys 
        595                 600                 605


Ala Leu Leu Phe 
    610


<210>  2382
<211>  1532
<212>  DNA
<213>  Homo sapiens

<400>  2382
gagcaggctt ggcgttgatt tgcctctgtg agtggggaga gcagggcttt gtattttcac     60

gctgaaaatc actgtctctc ctggaagaag gagaaacagg tagccgttga gagtaacgag    120

atgttagtgt attcggaacg gaactgctca gtcttcaatt ttggccttat cttgtcaagg    180

tcctgtagcc caatcccaaa tttccaagct ctctggcctg gtatcagtct tgtccttggt    240

ggtgcaggag gcagggtacg gcaaaagaca gacgggcccg agcccgccgc ccgctgcagc    300

tgccaggcga tcggatgggg aggatggaag cttggaccag gataacagga agcagaagag    360

cagctggctg atgctcaagg gggatgcaga cacaaggacc aattctccag acctggacac    420

ccagtccttg tcccacagca gcgggaccga cagagaccct ctccaaagga tggcagggga    480

cagctttcac tcacgtgagt ggttcttttg aagaaggagc cgtgatgtgc acaaaatgcc    540

tcgcggcaaa gaggccccag aactcagagc tatcccccta catctaagcc ttgcctgtta    600

aaaagcatga aagcaaagcc cacaaatcta aggaccgacc ggaaggaaat atggggcttt    660

tgcagtttgc cggcttccca agaactgtcc ccgagccagt gtgctaacga gggccacgcc    720

tgcatgtccc ctcacagatt tccaaggtgt gcaagaatgc agaaacccag acctgctcct    780

gggctgttta ggagaaaggc gtccgggctg ccgggtggaa gtcagggcct gttccctcca    840

gagcagacat gggcatggtc cggctgatga gtgcagactt ggagttggtg atgggcacca    900

tccctgtccc ctgtgactca tcctgaacga ggcacagcct caggcttcat agagagacag    960

tgatggtgtc tgcctgaccc taggggtgtt ttgaagactg aatcaggagt gattttcaaa   1020

tgtagagaaa actccagata atgctgtttg cttccggccg ctgtaaatca taggtgaaaa   1080

ccagtagcaa gtgctcactc agtgcctccc agaagcggtc tgcgggtctc agctgggctg   1140

ggggcagttt tcattgggca aggcttgggc ttagcttcga agcaggggct gggagaggat   1200

ggatgggggt gtgagagcag aagaaagacc tggctttgca gtgaggcagt cccaagttca   1260

aatctgagct caccactgac ccgtcgtgtg atgggcgcca ggtgttagga gactggaact   1320

gggtatgtgt gtggcattcg gccggccata gtagctgctc agtaaacaga aactgtttct   1380

catcctcatc ctcatcctca tgcctgcaaa ctgtaaaccg tcctacttaa caatgaaagt   1440

agaaaagtgt ttcaatgtga caggaaagag tgaagacaca gaagcttgga aatgatgatg   1500

tgttaaagaa tcactttaaa caaagaaagg tg                                 1532


<210>  2383
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  2383

Met Leu Val Tyr Ser Glu Arg Asn Cys Ser Val Phe Asn Phe Gly Leu 
1               5                   10                  15


Ile Leu Ser Arg Ser Cys Ser Pro Ile Pro Asn Phe Gln Ala Leu Trp 
            20                  25                  30


Pro Gly Ile Ser Leu Val Leu Gly Gly Ala Gly Gly Arg Val Arg Gln 
        35                  40                  45


Lys Thr Asp Gly Pro Glu Pro Ala Ala Arg Cys Ser Cys Gln Ala Ile 
    50                  55                  60


Gly Trp Gly Gly Trp Lys Leu Gly Pro Gly 
65                  70


<210>  2384
<211>  2577
<212>  DNA
<213>  Homo sapiens

<400>  2384
tgcggcggcg ctgcctggcg tgtgcgcaag gagcgggcgc ggagccggcg ggcgggcgga     60

ggatagcgcg ggcgcggcac ctgcgggccc gagggtctgg ctgtcgcagc gccgggccgc    120

cccgactccg agcggctgct gagatgagtg cagtgtcgca gccccaggct gctcccagcc    180

cgctggagaa gtcgcccagc acggcgatcc tgtgcaacac gtgtgggaat gtgtgcaagg    240

gcgaggtgct gcgggtgcag gacaagtact tccacatcaa gtgcttcgtc tgtaaagcat    300

gtggctgcga cctggccgag ggcggcttct tcgtgcggca gggcgagtac atctgcacgc    360

tggactacca gaggctctac ggcacccgct gcttcagctg cgaccagttc attgagggtg    420

aggtggtgtc ggcgctgggc aagacctacc accccgactg cttcgtgtgt gccgtctgcc    480

ggctgccctt cccccccggg gaccgagtga ccttcaacgg gaaggaatgc atgtgccaga    540

agtgttccct gcccgtatcg gtgggcagca gcgcgcacct gtcccagggc ctccgaagtt    600

gtgggggctg cggcacagaa atcaagaatg gccaggccct ggtagccttg gacaagcact    660

ggcacttggg ctgttttaag tgcaagagct gtgggaagct cctgaatgcc gagtacatca    720

gcaaggatgg gctgccctac tgcgaagctg actatcacgc caagttcggc atccgctgtg    780

acagctgtga gaaatacatc acggggcgcg tgctggaggc cggagagaag cactaccacc    840

cttcctgcgc gctatgtgtc aggtgcggcc agatgtttgc agaaggcgaa gagatgtatc    900

ttcaaggttc ctccatctgg catccggcgt gtcgacaagc agccagaact gaagacagaa    960

acaaggaaac cagaacttcc tcagagagca tcatttctgt ccctgcttcc agcacctcag   1020

ggtctccgag ccgtgtgatt tatgccaagc ttggtggtga gatcctggac tacagggact   1080

tggcagccct tcctaaaagt aaggccatct atgacatcga ccgccccgac atgatctcct   1140

actcacccta catcagccac tctgcagggg acaggcagag ctacggcgag tcccctcagt   1200

tgctctcgcc aacgccgacc gagggggatc aggatgaccg gtcctacaag cagtgtcgga   1260

cctccagccc aagctccact gggtcggtta gcctcgggcg ctacactccg acctcacggt   1320

caccacagca ctacagccgt ccagctgcca ggcgatcgga tggggaggat ggaagcttgg   1380

accaggataa caggaagcag aagagcagct ggctgatgct caagggggat gcagacacaa   1440

ggaccaattc tccagacctg gacacccagt ccttgtccca cagcagcggg accgacagag   1500

accctctcca aaggatggca ggggacagct ttcactcacg tgagtggttc ttttgaagaa   1560

ggagccgtga tgtgcacaaa atgcctcgcg gcaaagaggc cccagaactc agagctatcc   1620

ccctacatct aagccttgcc tgttaaaaag catgaaagca aagcccacaa atctaaggac   1680

cgaccggaag gaaatatggg gcttttgcag tttgccggct tcccaagaac tgtccccgag   1740

ccagtgtgct aacgagggcc acgcctgcat gtcccctcac agatttccaa ggtgtgcaag   1800

aatgcagaaa cccagacctg ctcctgggct gtttaggaga aaggcgtccg ggctgccggg   1860

tggaagtcag ggcctgttcc ctccagagca gacatgggca tggtccggct gatgagtgca   1920

gacttggagt tggtgatggg caccatccct gtcccctgtg actcatcctg aacgaggcac   1980

agcctcaggc ttcatagaga gacagtgatg gtgtctgcct gaccctaggg gtgttttgaa   2040

gactgaatca ggagtgattt tcaaatgtag agaaaactcc agataatgct gtttgcttcc   2100

ggccgctgta aatcataggt gaaaaccagt agcaagtgct cactcagtgc ctcccagaag   2160

cggtctgcgg gtctcagctg ggctgggggc agttttcatt gggcaaggct tgggcttagc   2220

ttcgaagcag gggctgggag aggatggatg ggggtgtgag agcagaagaa agacctggct   2280

ttgcagtgag gcagtcccaa gttcaaatct gagctcacca ctgacccgtc gtgtgatggg   2340

cgccaggtgt taggagactg gaactgggta tgtgtgtggc attcggccgg ccatagtagc   2400

tgctcagtaa acagaaactg tttctcatcc tcatcctcat cctcatgcct gcaaactgta   2460

aaccgtccta cttaacaatg aaagtagaaa agtgtttcaa tgtgacagga aagagtgaag   2520

acacagaagc ttggaaatga tgatgtgtta aagaatcact ttaaacaaag aaaggtg      2577


<210>  2385
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  2385

Met Ser Ala Val Ser Gln Pro Gln Ala Ala Pro Ser Pro Leu Glu Lys 
1               5                   10                  15


Ser Pro Ser Thr Ala Ile Leu Cys Asn Thr Cys Gly Asn Val Cys Lys 
            20                  25                  30


Gly Glu Val Leu Arg Val Gln Asp Lys Tyr Phe His Ile Lys Cys Phe 
        35                  40                  45


Val Cys Lys Ala Cys Gly Cys Asp Leu Ala Glu Gly Gly Phe Phe Val 
    50                  55                  60


Arg Gln Gly Glu Tyr Ile Cys Thr Leu Asp Tyr Gln Arg Leu Tyr Gly 
65                  70                  75                  80


Thr Arg Cys Phe Ser Cys Asp Gln Phe Ile Glu Gly Glu Val Val Ser 
                85                  90                  95


Ala Leu Gly Lys Thr Tyr His Pro Asp Cys Phe Val Cys Ala Val Cys 
            100                 105                 110


Arg Leu Pro Phe Pro Pro Gly Asp Arg Val Thr Phe Asn Gly Lys Glu 
        115                 120                 125


Cys Met Cys Gln Lys Cys Ser Leu Pro Val Ser Val Gly Ser Ser Ala 
    130                 135                 140


His Leu Ser Gln Gly Leu Arg Ser Cys Gly Gly Cys Gly Thr Glu Ile 
145                 150                 155                 160


Lys Asn Gly Gln Ala Leu Val Ala Leu Asp Lys His Trp His Leu Gly 
                165                 170                 175


Cys Phe Lys Cys Lys Ser Cys Gly Lys Leu Leu Asn Ala Glu Tyr Ile 
            180                 185                 190


Ser Lys Asp Gly Leu Pro Tyr Cys Glu Ala Asp Tyr His Ala Lys Phe 
        195                 200                 205


Gly Ile Arg Cys Asp Ser Cys Glu Lys Tyr Ile Thr Gly Arg Val Leu 
    210                 215                 220


Glu Ala Gly Glu Lys His Tyr His Pro Ser Cys Ala Leu Cys Val Arg 
225                 230                 235                 240


Cys Gly Gln Met Phe Ala Glu Gly Glu Glu Met Tyr Leu Gln Gly Ser 
                245                 250                 255


Ser Ile Trp His Pro Ala Cys Arg Gln Ala Ala Arg Thr Glu Asp Arg 
            260                 265                 270


Asn Lys Glu Thr Arg Thr Ser Ser Glu Ser Ile Ile Ser Val Pro Ala 
        275                 280                 285


Ser Ser Thr Ser Gly Ser Pro Ser Arg Val Ile Tyr Ala Lys Leu Gly 
    290                 295                 300


Gly Glu Ile Leu Asp Tyr Arg Asp Leu Ala Ala Leu Pro Lys Ser Lys 
305                 310                 315                 320


Ala Ile Tyr Asp Ile Asp Arg Pro Asp Met Ile Ser Tyr Ser Pro Tyr 
                325                 330                 335


Ile Ser His Ser Ala Gly Asp Arg Gln Ser Tyr Gly Glu Ser Pro Gln 
            340                 345                 350


Leu Leu Ser Pro Thr Pro Thr Glu Gly Asp Gln Asp Asp Arg Ser Tyr 
        355                 360                 365


Lys Gln Cys Arg Thr Ser Ser Pro Ser Ser Thr Gly Ser Val Ser Leu 
    370                 375                 380


Gly Arg Tyr Thr Pro Thr Ser Arg Ser Pro Gln His Tyr Ser Arg Pro 
385                 390                 395                 400


Ala Ala Arg Arg Ser Asp Gly Glu Asp Gly Ser Leu Asp Gln Asp Asn 
                405                 410                 415


Arg Lys Gln Lys Ser Ser Trp Leu Met Leu Lys Gly Asp Ala Asp Thr 
            420                 425                 430


Arg Thr Asn Ser Pro Asp Leu Asp Thr Gln Ser Leu Ser His Ser Ser 
        435                 440                 445


Gly Thr Asp Arg Asp Pro Leu Gln Arg Met Ala Gly Asp Ser Phe His 
    450                 455                 460


Ser Arg Glu Trp Phe Phe 
465                 470


<210>  2386
<211>  1396
<212>  DNA
<213>  Homo sapiens

<400>  2386
gtggatgaag aaatagtggc gtatctatgc cagggagtat tattcagcca cagacaggaa     60

tgaaagcact gatcctgcta caacatggat gaactctgaa aacgtgtgca gtgaaagatg    120

ccagacgcaa agccacgggg tagaggattc cttcactatg gaaaatccgg agcaggcaaa    180

tccatggaga cagaaagcag aggaggaggt cgaggctcag agaggcgagg ggggcctacc    240

caaggccatg tcattgagag aatgaggagc caggatccaa agaaggcagg ctggatgcta    300

cctcctggga agactccatg ggccatgggg acaatcgggg acatttgtgg ctgagcccct    360

gcaggtccgg ggcctcagag cacggaatta actgcatcct cagctcaccg gctccctgtc    420

aacagccctc ctcccacacc caacgcacag acacaggaaa aggaagggtc gcagagctcc    480

tagtgagctg ggggcagaga cggaagcctt ccacgctgta cacgccacgg cctggcccat    540

ggcacagagg agcagcctgg ggtctgagaa gtcacacagc agagttagag ccaagtctga    600

gccagtgcca gctctgcacc ctttccagtg atggcacagc cgcgtggcca ggggcagccg    660

gcaccctcac tcacagttcg ggccactcat aaagtatgag agtcaacagc caaaccctta    720

cattttaagg acgctccatg ttctggaaca atccacccat ggtggagggg cagggctgga    780

gggcctgtgt cttcaggctc tgaggaacac cacggggccg tcaagtggac ggagcaaatg    840

tgcctgccgg tgctcaggcc tgtcccaggc tcgtggccaa agccatggag gtgacagatt    900

ccagcctgag attctctctt cctggctgtg tgactcaggc cctgtgtcac gtgctggggt    960

tcagtgtccc cgtgtataag atggagagga ctgtccctcc ctctcaggct ggggtagtat   1020

aaccgggctc tgtgattcca gaggacattt agctggaagg taccggcatg gcacaggtca   1080

ccccctccct accccatact tcctgctgag aaccagtggg tcacaggcgg ccatcgatgg   1140

gctgatggag tcaaaaatta gaagtgtcct cattccctgt gtcacctcct gttgtcattc   1200

ccattctctc atagtgactg gggcgtccca gtcatcggta cagtggccac atcctcccaa   1260

ttgccacccg aggagtgcct gaaacctcgg ccgctggttg ttccagtggg cgcacggctc   1320

cccaggcagg cggaagtccc accctcgccc gcgtggggct catgatggct cggatttcaa   1380

aatatatgag caactg                                                   1396


<210>  2387
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  2387

Met Pro Asp Ala Lys Pro Arg Gly Arg Gly Phe Leu His Tyr Gly Lys 
1               5                   10                  15


Ser Gly Ala Gly Lys Ser Met Glu Thr Glu Ser Arg Gly Gly Gly Arg 
            20                  25                  30


Gly Ser Glu Arg Arg Gly Gly Pro Thr Gln Gly His Val Ile Glu Arg 
        35                  40                  45


Met Arg Ser Gln Asp Pro Lys Lys Ala Gly Trp Met Leu Pro Pro Gly 
    50                  55                  60


Lys Thr Pro Trp Ala Met Gly Thr Ile Gly Asp Ile Cys Gly 
65                  70                  75


<210>  2388
<211>  553
<212>  DNA
<213>  Homo sapiens

<400>  2388
gcaaggagcg ggcgcggagc cggcgggcgg gcggaggata gcgcgggcgc ggcacctgcg     60

ggcccgaggg tctggctgtc gcagcgccgg gccgccccga ctccgagcgg ctgctgagat    120

gagtgcagtg tcgcagcccc aggctgctcc cagcccgctg gagaagtcgc ccagcacggc    180

gatcctgtgc aacacgtgtg ggaatgtgtg caagggcgag gtgctgcggg tgcaggacaa    240

gtacttccac atcaagtgct tcgtctgtaa agcatgtggc tgcgacctgg ccgagggcgg    300

cttcttcgtg cggcagggcg agtacatctg cacgctggac taccagaggc tctacggcac    360

ccgctgcttc agctgcgacc agttcattga gggtgaggtg gtgtcggcgc tgggcaagac    420

ctaccacccc gactgcttcg tgtgtgccgt ctgccggtga gtaagtgggc acctggcctc    480

tgcttcccct gcctctctgg gccttttctc cttccctccc tcccttccct tcttcctcct    540

gctccctccc gtg                                                       553


<210>  2389
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  2389

Met Ser Ala Val Ser Gln Pro Gln Ala Ala Pro Ser Pro Leu Glu Lys 
1               5                   10                  15


Ser Pro Ser Thr Ala Ile Leu Cys Asn Thr Cys Gly Asn Val Cys Lys 
            20                  25                  30


Gly Glu Val Leu Arg Val Gln Asp Lys Tyr Phe His Ile Lys Cys Phe 
        35                  40                  45


Val Cys Lys Ala Cys Gly Cys Asp Leu Ala Glu Gly Gly Phe Phe Val 
    50                  55                  60


Arg Gln Gly Glu Tyr Ile Cys Thr Leu Asp Tyr Gln Arg Leu Tyr Gly 
65                  70                  75                  80


Thr Arg Cys Phe Ser Cys Asp Gln Phe Ile Glu Gly Glu Val Val Ser 
                85                  90                  95


Ala Leu Gly Lys Thr Tyr His Pro Asp Cys Phe Val Cys Ala Val Cys 
            100                 105                 110


Arg 



<210>  2390
<211>  4116
<212>  DNA
<213>  Homo sapiens

<400>  2390
acaaacgtgg tctcagatgt tgggtatccc ccatgccccc gccaaaagca ctccagatga     60

caaaaatcca ctacaaagct cttctttaaa aagaaagatt ctgagaagtt ccatcaaaag    120

aagaaaagaa gaaatgaagg gatggtgcct tgagtgaatg acccccttgg agaacattct    180

tccgcatccc tcgcctcaag ccagcctcag acagaaaact gaagattcag cagatccagt    240

gcttcctgct cctcttctgc ccaggaacac gcttgccttc cccaaggctt ccagaagctc    300

tgaggcagga ggcaccaagt tctacctcat gtttggagga tcttgctagc tatggccctc    360

gtactcggct ccctgttgct gctggggctg tgcgggaact ccttttcagg agggcagcct    420

tcatccacag atgctcctaa ggcttggaat tatgaattgc ctgcaacaaa ttatgagacc    480

caagactccc ataaagctgg acccattggc attctctttg aactagtgca tatctttctc    540

tatgtggtac agccgcgtga tttcccagaa gatactttga gaaaattctt acagaaggca    600

tatgaatcca aaattgatta tgacaagcca gaaactgtaa tcttaggtct aaagattgtc    660

tactatgaag cagggattat tctatgctgt gtcctggggc tgctgtttat tattctgatg    720

cctctggtgg ggtatttctt ttgtatgtgt cgttgctgta acaaatgtgg tggagaaatg    780

caccagcgac agaaggaaaa tgggcccttc ctgaggaaat gctttgcaat ctccctgttg    840

gtgatttgta taataataag cattggcatc ttctatggtt ttgtggcaaa tcaccaggta    900

agaacccgga tcaaaaggag tcggaaactg gcagatagca atttcaagga cttgcgaact    960

ctcttgaatg aaactccaga gcaaatcaaa tatatattgg cccagtacaa cactaccaag   1020

gacaaggcgt tcacagatct gaacagtatc aattcagtgc taggaggcgg aattcttgac   1080

cgactgagac ccaacatcat ccctgttctt gatgagatta agtccatggc aacagcgatc   1140

aaggagacca aagaggcgtt ggagaacatg aacagcacct tgaagagctt gcaccaacaa   1200

agtacacagc ttagcagcag tctgaccagc gtgaaaacta gcctgcggtc atctctcaat   1260

gaccctctgt gcttggtgca tccatcaagt gaaacctgca acagcatcag attgtctcta   1320

agccagctga atagcaaccc tgaactgagg cagcttccac ccgtggatgc agaacttgac   1380

aacgttaata acgttcttag gacagatttg gatggcctgg tccaacaggg ctatcaatcc   1440

cttaatgata tacctgacag agtacaacgc caaaccacga ctgtcgtagc aggtatcaaa   1500

agggtcttga attccattgg ttcagatatc gacaatgtaa ctcagcgtct tcctattcag   1560

gatatactct cagcattctc tgtttatgtt aataacactg aaagttacat ccacagaaat   1620

ttacctacat tggaagagta tgattcatac tggtggctgg gtggcctggt catctgctct   1680

ctgctgaccc tcatcgtgat tttttactac ctgggcttac tgtgtggcgt gtgcggctat   1740

gacaggcatg ccaccccgac cacccgaggc tgtgtctcca acaccggagg cgtcttcctc   1800

atggttggag ttggattaag tttcctcttt tgctggatat tgatgatcat tgtggttctt   1860

acctttgtct ttggtgcaaa tgtggaaaaa ctgatctgtg aaccttacac gagcaaggaa   1920

ttattccggg ttttggatac accctactta ctaaatgaag actgggaata ctatctctct   1980

gggaagctat ttaataaatc aaaaatgaag ctcacttttg aacaagttta cagtgactgc   2040

aaaaaaaata gaggcactta cggcactctt cacctgcaga acagcttcaa tatcagtgaa   2100

catctcaaca ttaatgagca tactggaagc ataagcagtg aattggaaag tctgaaggta   2160

aatcttaata tctttctgtt gggtgcagca ggaagaaaaa accttcagga ttttgctgct   2220

tgtggaatag acagaatgaa ttatgacagc tacttggctc agactggtaa atcccccgca   2280

ggagtgaatc ttttatcatt tgcatatgat ctagaagcaa aagcaaacag tttgccccca   2340

ggaaatttga ggaactccct gaaaagagat gcacaaacta ttaaaacaat tcaccagcaa   2400

cgagtccttc ctatagaaca atcactgagc actctatacc aaagcgtcaa gatacttcaa   2460

cgcacaggga atggattgtt ggagagagta actaggattc tagcttctct ggattttgct   2520

cagaacttca tcacaaacaa tacttcctct gttattattg aggaaactaa gaagtatggg   2580

agaacaataa taggatattt tgaacattat ctgcagtgga tcgagttctc tatcagtgag   2640

aaagtggcat cgtgcaaacc tgtggccacc gctctagata ctgctgttga tgtctttctg   2700

tgtagctaca ttatcgaccc cttgaatttg ttttggtttg gcataggaaa agctactgta   2760

tttttacttc cggctctaat ttttgcggta aaactggcta agtactatcg tcgaatggat   2820

tcggaggacg tgtacgatga tgttgaaact atacccatga aaaatatgga aaatggtaat   2880

aatggttatc ataaagatca tgtatatggt attcacaatc ctgttatgac aagcccatca   2940

caacattgat agctgatgtt gaaactgctt gagcatcagg atactcaaag tggaaaggat   3000

cacagatttt tggtagtttc tgggtctaca aggactttcc aaatccagga gcaacgccag   3060

tggcaacgta gtgactcagg cgggcaccaa ggcaacggca ccattggtct ctgggtagtg   3120

ctttaagaat gaacacaatc acgttatagt ccatggtcca tcactattca aggatgactc   3180

cctcccttcc tgtctatttt tgttttttac ttttttacac tgagtttcta tttagacact   3240

acaacatatg gggtgtttgt tcccattgga tgcatttcta tcaaaactct atcaaatgtg   3300

atggctagat tctaacatat tgccatgtgt ggagtgtgct gaacacacac cagtttacag   3360

gaaagatgca ttttgtgtac agtaaacggt gtatatacct tttgttacca cagagttttt   3420

taaacaaatg agtattatag gactttcttc taaatgagct aaataagtca ccattgactt   3480

cttggtgctg ttgaaaataa tccattttca ctaaaagtgt gtgaaaccta cagcatattc   3540

ttcacgcaga gattttcatc tattatactt tatcaaagat tggccatgtt ccacttggaa   3600

atggcatgca aaagcaatca tagagaaacc tgcgtaactc catctgacaa attcaaaaga   3660

gagagagaga tcttgagaga gaaatgctgt tcgttcaaaa gtggagttgt tttaacagat   3720

gccaattacg gtgtacagtt taacagagtt ttctgttgca ttacgataaa cattaattgg   3780

agtgcagcta acatgagtat catcagacta gtatcaagtg ttctaaaatg aaatatgaga   3840

agatcctgtc acaattctta gatctggtgt ccagcatgga tgaaaccttt gagtttggtc   3900

cctaaatttg catgaaagca caaggtaaat attcatttgc ttcaggagtt tcatgttgga   3960

tctgtcatta tcaaaagtga tcagcaatga agaactggtc ggacaaaatt taacgttgat   4020

gtaatgaaat tccagatgta ggcattcccc ccaggtcttt tcatgtgcag attgcagttc   4080

tgattcattt gaataaaaag gaacttggaa aacatg                             4116


<210>  2391
<211>  865
<212>  PRT
<213>  Homo sapiens

<400>  2391

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Pro Glu Thr Val 
                85                  90                  95


Ile Leu Gly Leu Lys Ile Val Tyr Tyr Glu Ala Gly Ile Ile Leu Cys 
            100                 105                 110


Cys Val Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly Tyr 
        115                 120                 125


Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His 
    130                 135                 140


Gln Arg Gln Lys Glu Asn Gly Pro Phe Leu Arg Lys Cys Phe Ala Ile 
145                 150                 155                 160


Ser Leu Leu Val Ile Cys Ile Ile Ile Ser Ile Gly Ile Phe Tyr Gly 
                165                 170                 175


Phe Val Ala Asn His Gln Val Arg Thr Arg Ile Lys Arg Ser Arg Lys 
            180                 185                 190


Leu Ala Asp Ser Asn Phe Lys Asp Leu Arg Thr Leu Leu Asn Glu Thr 
        195                 200                 205


Pro Glu Gln Ile Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp 
    210                 215                 220


Lys Ala Phe Thr Asp Leu Asn Ser Ile Asn Ser Val Leu Gly Gly Gly 
225                 230                 235                 240


Ile Leu Asp Arg Leu Arg Pro Asn Ile Ile Pro Val Leu Asp Glu Ile 
                245                 250                 255


Lys Ser Met Ala Thr Ala Ile Lys Glu Thr Lys Glu Ala Leu Glu Asn 
            260                 265                 270


Met Asn Ser Thr Leu Lys Ser Leu His Gln Gln Ser Thr Gln Leu Ser 
        275                 280                 285


Ser Ser Leu Thr Ser Val Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp 
    290                 295                 300


Pro Leu Cys Leu Val His Pro Ser Ser Glu Thr Cys Asn Ser Ile Arg 
305                 310                 315                 320


Leu Ser Leu Ser Gln Leu Asn Ser Asn Pro Glu Leu Arg Gln Leu Pro 
                325                 330                 335


Pro Val Asp Ala Glu Leu Asp Asn Val Asn Asn Val Leu Arg Thr Asp 
            340                 345                 350


Leu Asp Gly Leu Val Gln Gln Gly Tyr Gln Ser Leu Asn Asp Ile Pro 
        355                 360                 365


Asp Arg Val Gln Arg Gln Thr Thr Thr Val Val Ala Gly Ile Lys Arg 
    370                 375                 380


Val Leu Asn Ser Ile Gly Ser Asp Ile Asp Asn Val Thr Gln Arg Leu 
385                 390                 395                 400


Pro Ile Gln Asp Ile Leu Ser Ala Phe Ser Val Tyr Val Asn Asn Thr 
                405                 410                 415


Glu Ser Tyr Ile His Arg Asn Leu Pro Thr Leu Glu Glu Tyr Asp Ser 
            420                 425                 430


Tyr Trp Trp Leu Gly Gly Leu Val Ile Cys Ser Leu Leu Thr Leu Ile 
        435                 440                 445


Val Ile Phe Tyr Tyr Leu Gly Leu Leu Cys Gly Val Cys Gly Tyr Asp 
    450                 455                 460


Arg His Ala Thr Pro Thr Thr Arg Gly Cys Val Ser Asn Thr Gly Gly 
465                 470                 475                 480


Val Phe Leu Met Val Gly Val Gly Leu Ser Phe Leu Phe Cys Trp Ile 
                485                 490                 495


Leu Met Ile Ile Val Val Leu Thr Phe Val Phe Gly Ala Asn Val Glu 
            500                 505                 510


Lys Leu Ile Cys Glu Pro Tyr Thr Ser Lys Glu Leu Phe Arg Val Leu 
        515                 520                 525


Asp Thr Pro Tyr Leu Leu Asn Glu Asp Trp Glu Tyr Tyr Leu Ser Gly 
    530                 535                 540


Lys Leu Phe Asn Lys Ser Lys Met Lys Leu Thr Phe Glu Gln Val Tyr 
545                 550                 555                 560


Ser Asp Cys Lys Lys Asn Arg Gly Thr Tyr Gly Thr Leu His Leu Gln 
                565                 570                 575


Asn Ser Phe Asn Ile Ser Glu His Leu Asn Ile Asn Glu His Thr Gly 
            580                 585                 590


Ser Ile Ser Ser Glu Leu Glu Ser Leu Lys Val Asn Leu Asn Ile Phe 
        595                 600                 605


Leu Leu Gly Ala Ala Gly Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys 
    610                 615                 620


Gly Ile Asp Arg Met Asn Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys 
625                 630                 635                 640


Ser Pro Ala Gly Val Asn Leu Leu Ser Phe Ala Tyr Asp Leu Glu Ala 
                645                 650                 655


Lys Ala Asn Ser Leu Pro Pro Gly Asn Leu Arg Asn Ser Leu Lys Arg 
            660                 665                 670


Asp Ala Gln Thr Ile Lys Thr Ile His Gln Gln Arg Val Leu Pro Ile 
        675                 680                 685


Glu Gln Ser Leu Ser Thr Leu Tyr Gln Ser Val Lys Ile Leu Gln Arg 
    690                 695                 700


Thr Gly Asn Gly Leu Leu Glu Arg Val Thr Arg Ile Leu Ala Ser Leu 
705                 710                 715                 720


Asp Phe Ala Gln Asn Phe Ile Thr Asn Asn Thr Ser Ser Val Ile Ile 
                725                 730                 735


Glu Glu Thr Lys Lys Tyr Gly Arg Thr Ile Ile Gly Tyr Phe Glu His 
            740                 745                 750


Tyr Leu Gln Trp Ile Glu Phe Ser Ile Ser Glu Lys Val Ala Ser Cys 
        755                 760                 765


Lys Pro Val Ala Thr Ala Leu Asp Thr Ala Val Asp Val Phe Leu Cys 
    770                 775                 780


Ser Tyr Ile Ile Asp Pro Leu Asn Leu Phe Trp Phe Gly Ile Gly Lys 
785                 790                 795                 800


Ala Thr Val Phe Leu Leu Pro Ala Leu Ile Phe Ala Val Lys Leu Ala 
                805                 810                 815


Lys Tyr Tyr Arg Arg Met Asp Ser Glu Asp Val Tyr Asp Asp Val Glu 
            820                 825                 830


Thr Ile Pro Met Lys Asn Met Glu Asn Gly Asn Asn Gly Tyr His Lys 
        835                 840                 845


Asp His Val Tyr Gly Ile His Asn Pro Val Met Thr Ser Pro Ser Gln 
    850                 855                 860


His 
865


<210>  2392
<211>  4375
<212>  DNA
<213>  Homo sapiens

<400>  2392
gcatctgctg accaggcgcg gggctgagcg cactccttcc actgtactgg gggtgtacag     60

tgaggagtgg acgggttcgc tctgcgcccc ccttacccta gccatctgcg ccgcctccct    120

ggcccctcag caggtggtgc gggcccggac agcggctggg ggccagagga actgcgggga    180

gagcgtggtg gtgccggtgc ccgtccaacc caaacttttt agtctgagtg gtggcccgcg    240

acgccccgct tgggtcttct ttccatccac tggggatggg ggcgggggtg ggggtagccg    300

gcggccgtgg ttccggagcg ggagtcggag gtgagtgtgc gaactggacc ggggccccag    360

agacttcgga ctcgctctcg gggagaacgg tgaccgaggg atggtgcctt gagtgaatga    420

cccccttgga gaacattctt ccgcatccct cgcctcaagc cagcctcaga cagaaaactg    480

aagattcagc agatccagtg cttcctgctc ctcttctgcc caggaacacg cttgccttcc    540

ccaaggcttc cagaagctct gaggcaggag gcaccaagtt ctacctcatg tttggaggat    600

cttgctagct atggccctcg tactcggctc cctgttgctg ctggggctgt gcgggaactc    660

cttttcagga gggcagcctt catccacaga tgctcctaag gcttggaatt atgaattgcc    720

tgcaacaaat tatgagaccc aagactccca taaagctgga cccattggca ttctctttga    780

actagtgcat atctttctct atgtggtaca gccgcgtgat ttcccagaag atactttgag    840

aaaattctta cagaaggcat atgaatccaa aattgattat gacaagccag aaactgtaat    900

cttaggtcta aagattgtct actatgaagc agggattatt ctatgctgtg tcctggggct    960

gctgtttatt attctgatgc ctctggtggg gtatttcttt tgtatgtgtc gttgctgtaa   1020

caaatgtggt ggagaaatgc accagcgaca gaaggaaaat gggcccttcc tgaggaaatg   1080

ctttgcaatc tccctgttgg tgatttgtat aataataagc attggcatct tctatggttt   1140

tgtggcaaat caccaggtaa gaacccggat caaaaggagt cggaaactgg cagatagcaa   1200

tttcaaggac ttgcgaactc tcttgaatga aactccagag caaatcaaat atatattggc   1260

ccagtacaac actaccaagg acaaggcgtt cacagatctg aacagtatca attcagtgct   1320

aggaggcgga attcttgacc gactgagacc caacatcatc cctgttcttg atgagattaa   1380

gtccatggca acagcgatca aggagaccaa agaggcgttg gagaacatga acagcacctt   1440

gaagagcttg caccaacaaa gtacacagct tagcagcagt ctgaccagcg tgaaaactag   1500

cctgcggtca tctctcaatg accctctgtg cttggtgcat ccatcaagtg aaacctgcaa   1560

cagcatcaga ttgtctctaa gccagctgaa tagcaaccct gaactgaggc agcttccacc   1620

cgtggatgca gaacttgaca acgttaataa cgttcttagg acagatttgg atggcctggt   1680

ccaacagggc tatcaatccc ttaatgatat acctgacaga gtacaacgcc aaaccacgac   1740

tgtcgtagca ggtatcaaaa gggtcttgaa ttccattggt tcagatatcg acaatgtaac   1800

tcagcgtctt cctattcagg atatactctc agcattctct gtttatgtta ataacactga   1860

aagttacatc cacagaaatt tacctacatt ggaagagtat gattcatact ggtggctggg   1920

tggcctggtc atctgctctc tgctgaccct catcgtgatt ttttactacc tgggcttact   1980

gtgtggcgtg tgcggctatg acaggcatgc caccccgacc acccgaggct gtgtctccaa   2040

caccggaggc gtcttcctca tggttggagt tggattaagt ttcctctttt gctggatatt   2100

gatgatcatt gtggttctta cctttgtctt tggtgcaaat gtggaaaaac tgatctgtga   2160

accttacacg agcaaggaat tattccgggt tttggataca ccctacttac taaatgaaga   2220

ctgggaatac tatctctctg ggaagctatt taataaatca aaaatgaagc tcacttttga   2280

acaagtttac agtgactgca aaaaaaatag aggcacttac ggcactcttc acctgcagaa   2340

cagcttcaat atcagtgaac atctcaacat taatgagcat actggaagca taagcagtga   2400

attggaaagt ctgaaggtaa atcttaatat ctttctgttg ggtgcagcag gaagaaaaaa   2460

ccttcaggat tttgctgctt gtggaataga cagaatgaat tatgacagct acttggctca   2520

gactggtaaa tcccccgcag gagtgaatct tttatcattt gcatatgatc tagaagcaaa   2580

agcaaacagt ttgcccccag gaaatttgag gaactccctg aaaagagatg cacaaactat   2640

taaaacaatt caccagcaac gagtccttcc tatagaacaa tcactgagca ctctatacca   2700

aagcgtcaag atacttcaac gcacagggaa tggattgttg gagagagtaa ctaggattct   2760

agcttctctg gattttgctc agaacttcat cacaaacaat acttcctctg ttattattga   2820

ggaaactaag aagtatggga gaacaataat aggatatttt gaacattatc tgcagtggat   2880

cgagttctct atcagtgaga aagtggcatc gtgcaaacct gtggccaccg ctctagatac   2940

tgctgttgat gtctttctgt gtagctacat tatcgacccc ttgaatttgt tttggtttgg   3000

cataggaaaa gctactgtat ttttacttcc ggctctaatt tttgcggtaa aactggctaa   3060

gtactatcgt cgaatggatt cggaggacgt gtacgatgat gttgaaacta tacccatgaa   3120

aaatatggaa aatggtaata atggttatca taaagatcat gtatatggta ttcacaatcc   3180

tgttatgaca agcccatcac aacattgata gctgatgttg aaactgcttg agcatcagga   3240

tactcaaagt ggaaaggatc acagattttt ggtagtttct gggtctacaa ggactttcca   3300

aatccaggag caacgccagt ggcaacgtag tgactcaggc gggcaccaag gcaacggcac   3360

cattggtctc tgggtagtgc tttaagaatg aacacaatca cgttatagtc catggtccat   3420

cactattcaa ggatgactcc ctcccttcct gtctattttt gttttttact tttttacact   3480

gagtttctat ttagacacta caacatatgg ggtgtttgtt cccattggat gcatttctat   3540

caaaactcta tcaaatgtga tggctagatt ctaacatatt gccatgtgtg gagtgtgctg   3600

aacacacacc agtttacagg aaagatgcat tttgtgtaca gtaaacggtg tatatacctt   3660

ttgttaccac agagtttttt aaacaaatga gtattatagg actttcttct aaatgagcta   3720

aataagtcac cattgacttc ttggtgctgt tgaaaataat ccattttcac taaaagtgtg   3780

tgaaacctac agcatattct tcacgcagag attttcatct attatacttt atcaaagatt   3840

ggccatgttc cacttggaaa tggcatgcaa aagcaatcat agagaaacct gcgtaactcc   3900

atctgacaaa ttcaaaagag agagagagat cttgagagag aaatgctgtt cgttcaaaag   3960

tggagttgtt ttaacagatg ccaattacgg tgtacagttt aacagagttt tctgttgcat   4020

tacgataaac attaattgga gtgcagctaa catgagtatc atcagactag tatcaagtgt   4080

tctaaaatga aatatgagaa gatcctgtca caattcttag atctggtgtc cagcatggat   4140

gaaacctttg agtttggtcc ctaaatttgc atgaaagcac aaggtaaata ttcatttgct   4200

tcaggagttt catgttggat ctgtcattat caaaagtgat cagcaatgaa gaactggtcg   4260

gacaaaattt aacgttgatg taatgaaatt ccagatgtag gcattccccc caggtctttt   4320

catgtgcaga ttgcagttct gattcatttg aataaaaagg aacttggaaa acatg        4375


<210>  2393
<211>  865
<212>  PRT
<213>  Homo sapiens

<400>  2393

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Pro Glu Thr Val 
                85                  90                  95


Ile Leu Gly Leu Lys Ile Val Tyr Tyr Glu Ala Gly Ile Ile Leu Cys 
            100                 105                 110


Cys Val Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly Tyr 
        115                 120                 125


Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His 
    130                 135                 140


Gln Arg Gln Lys Glu Asn Gly Pro Phe Leu Arg Lys Cys Phe Ala Ile 
145                 150                 155                 160


Ser Leu Leu Val Ile Cys Ile Ile Ile Ser Ile Gly Ile Phe Tyr Gly 
                165                 170                 175


Phe Val Ala Asn His Gln Val Arg Thr Arg Ile Lys Arg Ser Arg Lys 
            180                 185                 190


Leu Ala Asp Ser Asn Phe Lys Asp Leu Arg Thr Leu Leu Asn Glu Thr 
        195                 200                 205


Pro Glu Gln Ile Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp 
    210                 215                 220


Lys Ala Phe Thr Asp Leu Asn Ser Ile Asn Ser Val Leu Gly Gly Gly 
225                 230                 235                 240


Ile Leu Asp Arg Leu Arg Pro Asn Ile Ile Pro Val Leu Asp Glu Ile 
                245                 250                 255


Lys Ser Met Ala Thr Ala Ile Lys Glu Thr Lys Glu Ala Leu Glu Asn 
            260                 265                 270


Met Asn Ser Thr Leu Lys Ser Leu His Gln Gln Ser Thr Gln Leu Ser 
        275                 280                 285


Ser Ser Leu Thr Ser Val Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp 
    290                 295                 300


Pro Leu Cys Leu Val His Pro Ser Ser Glu Thr Cys Asn Ser Ile Arg 
305                 310                 315                 320


Leu Ser Leu Ser Gln Leu Asn Ser Asn Pro Glu Leu Arg Gln Leu Pro 
                325                 330                 335


Pro Val Asp Ala Glu Leu Asp Asn Val Asn Asn Val Leu Arg Thr Asp 
            340                 345                 350


Leu Asp Gly Leu Val Gln Gln Gly Tyr Gln Ser Leu Asn Asp Ile Pro 
        355                 360                 365


Asp Arg Val Gln Arg Gln Thr Thr Thr Val Val Ala Gly Ile Lys Arg 
    370                 375                 380


Val Leu Asn Ser Ile Gly Ser Asp Ile Asp Asn Val Thr Gln Arg Leu 
385                 390                 395                 400


Pro Ile Gln Asp Ile Leu Ser Ala Phe Ser Val Tyr Val Asn Asn Thr 
                405                 410                 415


Glu Ser Tyr Ile His Arg Asn Leu Pro Thr Leu Glu Glu Tyr Asp Ser 
            420                 425                 430


Tyr Trp Trp Leu Gly Gly Leu Val Ile Cys Ser Leu Leu Thr Leu Ile 
        435                 440                 445


Val Ile Phe Tyr Tyr Leu Gly Leu Leu Cys Gly Val Cys Gly Tyr Asp 
    450                 455                 460


Arg His Ala Thr Pro Thr Thr Arg Gly Cys Val Ser Asn Thr Gly Gly 
465                 470                 475                 480


Val Phe Leu Met Val Gly Val Gly Leu Ser Phe Leu Phe Cys Trp Ile 
                485                 490                 495


Leu Met Ile Ile Val Val Leu Thr Phe Val Phe Gly Ala Asn Val Glu 
            500                 505                 510


Lys Leu Ile Cys Glu Pro Tyr Thr Ser Lys Glu Leu Phe Arg Val Leu 
        515                 520                 525


Asp Thr Pro Tyr Leu Leu Asn Glu Asp Trp Glu Tyr Tyr Leu Ser Gly 
    530                 535                 540


Lys Leu Phe Asn Lys Ser Lys Met Lys Leu Thr Phe Glu Gln Val Tyr 
545                 550                 555                 560


Ser Asp Cys Lys Lys Asn Arg Gly Thr Tyr Gly Thr Leu His Leu Gln 
                565                 570                 575


Asn Ser Phe Asn Ile Ser Glu His Leu Asn Ile Asn Glu His Thr Gly 
            580                 585                 590


Ser Ile Ser Ser Glu Leu Glu Ser Leu Lys Val Asn Leu Asn Ile Phe 
        595                 600                 605


Leu Leu Gly Ala Ala Gly Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys 
    610                 615                 620


Gly Ile Asp Arg Met Asn Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys 
625                 630                 635                 640


Ser Pro Ala Gly Val Asn Leu Leu Ser Phe Ala Tyr Asp Leu Glu Ala 
                645                 650                 655


Lys Ala Asn Ser Leu Pro Pro Gly Asn Leu Arg Asn Ser Leu Lys Arg 
            660                 665                 670


Asp Ala Gln Thr Ile Lys Thr Ile His Gln Gln Arg Val Leu Pro Ile 
        675                 680                 685


Glu Gln Ser Leu Ser Thr Leu Tyr Gln Ser Val Lys Ile Leu Gln Arg 
    690                 695                 700


Thr Gly Asn Gly Leu Leu Glu Arg Val Thr Arg Ile Leu Ala Ser Leu 
705                 710                 715                 720


Asp Phe Ala Gln Asn Phe Ile Thr Asn Asn Thr Ser Ser Val Ile Ile 
                725                 730                 735


Glu Glu Thr Lys Lys Tyr Gly Arg Thr Ile Ile Gly Tyr Phe Glu His 
            740                 745                 750


Tyr Leu Gln Trp Ile Glu Phe Ser Ile Ser Glu Lys Val Ala Ser Cys 
        755                 760                 765


Lys Pro Val Ala Thr Ala Leu Asp Thr Ala Val Asp Val Phe Leu Cys 
    770                 775                 780


Ser Tyr Ile Ile Asp Pro Leu Asn Leu Phe Trp Phe Gly Ile Gly Lys 
785                 790                 795                 800


Ala Thr Val Phe Leu Leu Pro Ala Leu Ile Phe Ala Val Lys Leu Ala 
                805                 810                 815


Lys Tyr Tyr Arg Arg Met Asp Ser Glu Asp Val Tyr Asp Asp Val Glu 
            820                 825                 830


Thr Ile Pro Met Lys Asn Met Glu Asn Gly Asn Asn Gly Tyr His Lys 
        835                 840                 845


Asp His Val Tyr Gly Ile His Asn Pro Val Met Thr Ser Pro Ser Gln 
    850                 855                 860


His 
865


<210>  2394
<211>  4307
<212>  DNA
<213>  Homo sapiens

<400>  2394
gcatctgctg accaggcgcg gggctgagcg cactccttcc actgtactgg gggtgtacag     60

tgaggagtgg acgggttcgc tctgcgcccc ccttacccta gccatctgcg ccgcctccct    120

ggcccctcag caggtggtgc gggcccggac agcggctggg ggccagagga actgcgggga    180

gagcgtggtg gtgccggtgc ccgtccaacc caaacttttt agtctgagtg gtggcccgcg    240

acgccccgct tgggtcttct ttccatccac tggggatggg ggcgggggtg ggggtagccg    300

gcggccgtgg ttccggagcg ggagtcggag ggatggtgcc ttgagtgaat gacccccttg    360

gagaacattc ttccgcatcc ctcgcctcaa gccagcctca gacagaaaac tgaagattca    420

gcagatccag tgcttcctgc tcctcttctg cccaggaaca cgcttgcctt ccccaaggct    480

tccagaagct ctgaggcagg aggcaccaag ttctacctca tgtttggagg atcttgctag    540

ctatggccct cgtactcggc tccctgttgc tgctggggct gtgcgggaac tccttttcag    600

gagggcagcc ttcatccaca gatgctccta aggcttggaa ttatgaattg cctgcaacaa    660

attatgagac ccaagactcc cataaagctg gacccattgg cattctcttt gaactagtgc    720

atatctttct ctatgtggta cagccgcgtg atttcccaga agatactttg agaaaattct    780

tacagaaggc atatgaatcc aaaattgatt atgacaagcc agaaactgta atcttaggtc    840

taaagattgt ctactatgaa gcagggatta ttctatgctg tgtcctgggg ctgctgttta    900

ttattctgat gcctctggtg gggtatttct tttgtatgtg tcgttgctgt aacaaatgtg    960

gtggagaaat gcaccagcga cagaaggaaa atgggccctt cctgaggaaa tgctttgcaa   1020

tctccctgtt ggtgatttgt ataataataa gcattggcat cttctatggt tttgtggcaa   1080

atcaccaggt aagaacccgg atcaaaagga gtcggaaact ggcagatagc aatttcaagg   1140

acttgcgaac tctcttgaat gaaactccag agcaaatcaa atatatattg gcccagtaca   1200

acactaccaa ggacaaggcg ttcacagatc tgaacagtat caattcagtg ctaggaggcg   1260

gaattcttga ccgactgaga cccaacatca tccctgttct tgatgagatt aagtccatgg   1320

caacagcgat caaggagacc aaagaggcgt tggagaacat gaacagcacc ttgaagagct   1380

tgcaccaaca aagtacacag cttagcagca gtctgaccag cgtgaaaact agcctgcggt   1440

catctctcaa tgaccctctg tgcttggtgc atccatcaag tgaaacctgc aacagcatca   1500

gattgtctct aagccagctg aatagcaacc ctgaactgag gcagcttcca cccgtggatg   1560

cagaacttga caacgttaat aacgttctta ggacagattt ggatggcctg gtccaacagg   1620

gctatcaatc ccttaatgat atacctgaca gagtacaacg ccaaaccacg actgtcgtag   1680

caggtatcaa aagggtcttg aattccattg gttcagatat cgacaatgta actcagcgtc   1740

ttcctattca ggatatactc tcagcattct ctgtttatgt taataacact gaaagttaca   1800

tccacagaaa tttacctaca ttggaagagt atgattcata ctggtggctg ggtggcctgg   1860

tcatctgctc tctgctgacc ctcatcgtga ttttttacta cctgggctta ctgtgtggcg   1920

tgtgcggcta tgacaggcat gccaccccga ccacccgagg ctgtgtctcc aacaccggag   1980

gcgtcttcct catggttgga gttggattaa gtttcctctt ttgctggata ttgatgatca   2040

ttgtggttct tacctttgtc tttggtgcaa atgtggaaaa actgatctgt gaaccttaca   2100

cgagcaagga attattccgg gttttggata caccctactt actaaatgaa gactgggaat   2160

actatctctc tgggaagcta tttaataaat caaaaatgaa gctcactttt gaacaagttt   2220

acagtgactg caaaaaaaat agaggcactt acggcactct tcacctgcag aacagcttca   2280

atatcagtga acatctcaac attaatgagc atactggaag cataagcagt gaattggaaa   2340

gtctgaaggt aaatcttaat atctttctgt tgggtgcagc aggaagaaaa aaccttcagg   2400

attttgctgc ttgtggaata gacagaatga attatgacag ctacttggct cagactggta   2460

aatcccccgc aggagtgaat cttttatcat ttgcatatga tctagaagca aaagcaaaca   2520

gtttgccccc aggaaatttg aggaactccc tgaaaagaga tgcacaaact attaaaacaa   2580

ttcaccagca acgagtcctt cctatagaac aatcactgag cactctatac caaagcgtca   2640

agatacttca acgcacaggg aatggattgt tggagagagt aactaggatt ctagcttctc   2700

tggattttgc tcagaacttc atcacaaaca atacttcctc tgttattatt gaggaaacta   2760

agaagtatgg gagaacaata ataggatatt ttgaacatta tctgcagtgg atcgagttct   2820

ctatcagtga gaaagtggca tcgtgcaaac ctgtggccac cgctctagat actgctgttg   2880

atgtctttct gtgtagctac attatcgacc ccttgaattt gttttggttt ggcataggaa   2940

aagctactgt atttttactt ccggctctaa tttttgcggt aaaactggct aagtactatc   3000

gtcgaatgga ttcggaggac gtgtacgatg atgttgaaac tatacccatg aaaaatatgg   3060

aaaatggtaa taatggttat cataaagatc atgtatatgg tattcacaat cctgttatga   3120

caagcccatc acaacattga tagctgatgt tgaaactgct tgagcatcag gatactcaaa   3180

gtggaaagga tcacagattt ttggtagttt ctgggtctac aaggactttc caaatccagg   3240

agcaacgcca gtggcaacgt agtgactcag gcgggcacca aggcaacggc accattggtc   3300

tctgggtagt gctttaagaa tgaacacaat cacgttatag tccatggtcc atcactattc   3360

aaggatgact ccctcccttc ctgtctattt ttgtttttta cttttttaca ctgagtttct   3420

atttagacac tacaacatat ggggtgtttg ttcccattgg atgcatttct atcaaaactc   3480

tatcaaatgt gatggctaga ttctaacata ttgccatgtg tggagtgtgc tgaacacaca   3540

ccagtttaca ggaaagatgc attttgtgta cagtaaacgg tgtatatacc ttttgttacc   3600

acagagtttt ttaaacaaat gagtattata ggactttctt ctaaatgagc taaataagtc   3660

accattgact tcttggtgct gttgaaaata atccattttc actaaaagtg tgtgaaacct   3720

acagcatatt cttcacgcag agattttcat ctattatact ttatcaaaga ttggccatgt   3780

tccacttgga aatggcatgc aaaagcaatc atagagaaac ctgcgtaact ccatctgaca   3840

aattcaaaag agagagagag atcttgagag agaaatgctg ttcgttcaaa agtggagttg   3900

ttttaacaga tgccaattac ggtgtacagt ttaacagagt tttctgttgc attacgataa   3960

acattaattg gagtgcagct aacatgagta tcatcagact agtatcaagt gttctaaaat   4020

gaaatatgag aagatcctgt cacaattctt agatctggtg tccagcatgg atgaaacctt   4080

tgagtttggt ccctaaattt gcatgaaagc acaaggtaaa tattcatttg cttcaggagt   4140

ttcatgttgg atctgtcatt atcaaaagtg atcagcaatg aagaactggt cggacaaaat   4200

ttaacgttga tgtaatgaaa ttccagatgt aggcattccc cccaggtctt ttcatgtgca   4260

gattgcagtt ctgattcatt tgaataaaaa ggaacttgga aaacatg                 4307


<210>  2395
<211>  865
<212>  PRT
<213>  Homo sapiens

<400>  2395

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Pro Glu Thr Val 
                85                  90                  95


Ile Leu Gly Leu Lys Ile Val Tyr Tyr Glu Ala Gly Ile Ile Leu Cys 
            100                 105                 110


Cys Val Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly Tyr 
        115                 120                 125


Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His 
    130                 135                 140


Gln Arg Gln Lys Glu Asn Gly Pro Phe Leu Arg Lys Cys Phe Ala Ile 
145                 150                 155                 160


Ser Leu Leu Val Ile Cys Ile Ile Ile Ser Ile Gly Ile Phe Tyr Gly 
                165                 170                 175


Phe Val Ala Asn His Gln Val Arg Thr Arg Ile Lys Arg Ser Arg Lys 
            180                 185                 190


Leu Ala Asp Ser Asn Phe Lys Asp Leu Arg Thr Leu Leu Asn Glu Thr 
        195                 200                 205


Pro Glu Gln Ile Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp 
    210                 215                 220


Lys Ala Phe Thr Asp Leu Asn Ser Ile Asn Ser Val Leu Gly Gly Gly 
225                 230                 235                 240


Ile Leu Asp Arg Leu Arg Pro Asn Ile Ile Pro Val Leu Asp Glu Ile 
                245                 250                 255


Lys Ser Met Ala Thr Ala Ile Lys Glu Thr Lys Glu Ala Leu Glu Asn 
            260                 265                 270


Met Asn Ser Thr Leu Lys Ser Leu His Gln Gln Ser Thr Gln Leu Ser 
        275                 280                 285


Ser Ser Leu Thr Ser Val Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp 
    290                 295                 300


Pro Leu Cys Leu Val His Pro Ser Ser Glu Thr Cys Asn Ser Ile Arg 
305                 310                 315                 320


Leu Ser Leu Ser Gln Leu Asn Ser Asn Pro Glu Leu Arg Gln Leu Pro 
                325                 330                 335


Pro Val Asp Ala Glu Leu Asp Asn Val Asn Asn Val Leu Arg Thr Asp 
            340                 345                 350


Leu Asp Gly Leu Val Gln Gln Gly Tyr Gln Ser Leu Asn Asp Ile Pro 
        355                 360                 365


Asp Arg Val Gln Arg Gln Thr Thr Thr Val Val Ala Gly Ile Lys Arg 
    370                 375                 380


Val Leu Asn Ser Ile Gly Ser Asp Ile Asp Asn Val Thr Gln Arg Leu 
385                 390                 395                 400


Pro Ile Gln Asp Ile Leu Ser Ala Phe Ser Val Tyr Val Asn Asn Thr 
                405                 410                 415


Glu Ser Tyr Ile His Arg Asn Leu Pro Thr Leu Glu Glu Tyr Asp Ser 
            420                 425                 430


Tyr Trp Trp Leu Gly Gly Leu Val Ile Cys Ser Leu Leu Thr Leu Ile 
        435                 440                 445


Val Ile Phe Tyr Tyr Leu Gly Leu Leu Cys Gly Val Cys Gly Tyr Asp 
    450                 455                 460


Arg His Ala Thr Pro Thr Thr Arg Gly Cys Val Ser Asn Thr Gly Gly 
465                 470                 475                 480


Val Phe Leu Met Val Gly Val Gly Leu Ser Phe Leu Phe Cys Trp Ile 
                485                 490                 495


Leu Met Ile Ile Val Val Leu Thr Phe Val Phe Gly Ala Asn Val Glu 
            500                 505                 510


Lys Leu Ile Cys Glu Pro Tyr Thr Ser Lys Glu Leu Phe Arg Val Leu 
        515                 520                 525


Asp Thr Pro Tyr Leu Leu Asn Glu Asp Trp Glu Tyr Tyr Leu Ser Gly 
    530                 535                 540


Lys Leu Phe Asn Lys Ser Lys Met Lys Leu Thr Phe Glu Gln Val Tyr 
545                 550                 555                 560


Ser Asp Cys Lys Lys Asn Arg Gly Thr Tyr Gly Thr Leu His Leu Gln 
                565                 570                 575


Asn Ser Phe Asn Ile Ser Glu His Leu Asn Ile Asn Glu His Thr Gly 
            580                 585                 590


Ser Ile Ser Ser Glu Leu Glu Ser Leu Lys Val Asn Leu Asn Ile Phe 
        595                 600                 605


Leu Leu Gly Ala Ala Gly Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys 
    610                 615                 620


Gly Ile Asp Arg Met Asn Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys 
625                 630                 635                 640


Ser Pro Ala Gly Val Asn Leu Leu Ser Phe Ala Tyr Asp Leu Glu Ala 
                645                 650                 655


Lys Ala Asn Ser Leu Pro Pro Gly Asn Leu Arg Asn Ser Leu Lys Arg 
            660                 665                 670


Asp Ala Gln Thr Ile Lys Thr Ile His Gln Gln Arg Val Leu Pro Ile 
        675                 680                 685


Glu Gln Ser Leu Ser Thr Leu Tyr Gln Ser Val Lys Ile Leu Gln Arg 
    690                 695                 700


Thr Gly Asn Gly Leu Leu Glu Arg Val Thr Arg Ile Leu Ala Ser Leu 
705                 710                 715                 720


Asp Phe Ala Gln Asn Phe Ile Thr Asn Asn Thr Ser Ser Val Ile Ile 
                725                 730                 735


Glu Glu Thr Lys Lys Tyr Gly Arg Thr Ile Ile Gly Tyr Phe Glu His 
            740                 745                 750


Tyr Leu Gln Trp Ile Glu Phe Ser Ile Ser Glu Lys Val Ala Ser Cys 
        755                 760                 765


Lys Pro Val Ala Thr Ala Leu Asp Thr Ala Val Asp Val Phe Leu Cys 
    770                 775                 780


Ser Tyr Ile Ile Asp Pro Leu Asn Leu Phe Trp Phe Gly Ile Gly Lys 
785                 790                 795                 800


Ala Thr Val Phe Leu Leu Pro Ala Leu Ile Phe Ala Val Lys Leu Ala 
                805                 810                 815


Lys Tyr Tyr Arg Arg Met Asp Ser Glu Asp Val Tyr Asp Asp Val Glu 
            820                 825                 830


Thr Ile Pro Met Lys Asn Met Glu Asn Gly Asn Asn Gly Tyr His Lys 
        835                 840                 845


Asp His Val Tyr Gly Ile His Asn Pro Val Met Thr Ser Pro Ser Gln 
    850                 855                 860


His 
865


<210>  2396
<211>  4485
<212>  DNA
<213>  Homo sapiens

<400>  2396
agctgggtcc tcatcccgga gcgagagagg catctgctga ccaggcgcgg ggctgagcgc     60

actccttcca ctgtactggg ggtgtacagt gaggagtgga cgggttcgct ctgcgccccc    120

cttaccctag ccatctgcgc cgcctccctg gcccctcagc aggtggtgcg ggcccggaca    180

gcggctgggg gccagaggaa ctgcggggag agcgtggtgg tgccggtgcc cgtccaaccc    240

aaacttttta gtctgagtgg tggcccgcga cgccccgctt gggtcttctt tccatccact    300

ggggatgggg gcgggggtgg gggtagccgg cggccgtggt tccggagcgg gagtcggagg    360

tgagtgtgcg aactggaccg gggccccaga gacttcggac tcgctctcgg ggagaacggt    420

gaccgaggag ccccggtgga gttgagctca gagtattgat gctagcagaa gcagacagac    480

cccagatagc cttccagctg cgtgccaggg atggtgcctt gagtgaatga cccccttgga    540

gaacattctt ccgcatccct cgcctcaagc cagcctcaga cagaaaactg aagattcagc    600

agatccagtg cttcctgctc ctcttctgcc caggaacacg cttgccttcc ccaaggcttc    660

cagaagctct gaggcaggag gcaccaagtt ctacctcatg tttggaggat cttgctagct    720

atggccctcg tactcggctc cctgttgctg ctggggctgt gcgggaactc cttttcagga    780

gggcagcctt catccacaga tgctcctaag gcttggaatt atgaattgcc tgcaacaaat    840

tatgagaccc aagactccca taaagctgga cccattggca ttctctttga actagtgcat    900

atctttctct atgtggtaca gccgcgtgat ttcccagaag atactttgag aaaattctta    960

cagaaggcat atgaatccaa aattgattat gacaagccag aaactgtaat cttaggtcta   1020

aagattgtct actatgaagc agggattatt ctatgctgtg tcctggggct gctgtttatt   1080

attctgatgc ctctggtggg gtatttcttt tgtatgtgtc gttgctgtaa caaatgtggt   1140

ggagaaatgc accagcgaca gaaggaaaat gggcccttcc tgaggaaatg ctttgcaatc   1200

tccctgttgg tgatttgtat aataataagc attggcatct tctatggttt tgtggcaaat   1260

caccaggtaa gaacccggat caaaaggagt cggaaactgg cagatagcaa tttcaaggac   1320

ttgcgaactc tcttgaatga aactccagag caaatcaaat atatattggc ccagtacaac   1380

actaccaagg acaaggcgtt cacagatctg aacagtatca attcagtgct aggaggcgga   1440

attcttgacc gactgagacc caacatcatc cctgttcttg atgagattaa gtccatggca   1500

acagcgatca aggagaccaa agaggcgttg gagaacatga acagcacctt gaagagcttg   1560

caccaacaaa gtacacagct tagcagcagt ctgaccagcg tgaaaactag cctgcggtca   1620

tctctcaatg accctctgtg cttggtgcat ccatcaagtg aaacctgcaa cagcatcaga   1680

ttgtctctaa gccagctgaa tagcaaccct gaactgaggc agcttccacc cgtggatgca   1740

gaacttgaca acgttaataa cgttcttagg acagatttgg atggcctggt ccaacagggc   1800

tatcaatccc ttaatgatat acctgacaga gtacaacgcc aaaccacgac tgtcgtagca   1860

ggtatcaaaa gggtcttgaa ttccattggt tcagatatcg acaatgtaac tcagcgtctt   1920

cctattcagg atatactctc agcattctct gtttatgtta ataacactga aagttacatc   1980

cacagaaatt tacctacatt ggaagagtat gattcatact ggtggctggg tggcctggtc   2040

atctgctctc tgctgaccct catcgtgatt ttttactacc tgggcttact gtgtggcgtg   2100

tgcggctatg acaggcatgc caccccgacc acccgaggct gtgtctccaa caccggaggc   2160

gtcttcctca tggttggagt tggattaagt ttcctctttt gctggatatt gatgatcatt   2220

gtggttctta cctttgtctt tggtgcaaat gtggaaaaac tgatctgtga accttacacg   2280

agcaaggaat tattccgggt tttggataca ccctacttac taaatgaaga ctgggaatac   2340

tatctctctg ggaagctatt taataaatca aaaatgaagc tcacttttga acaagtttac   2400

agtgactgca aaaaaaatag aggcacttac ggcactcttc acctgcagaa cagcttcaat   2460

atcagtgaac atctcaacat taatgagcat actggaagca taagcagtga attggaaagt   2520

ctgaaggtaa atcttaatat ctttctgttg ggtgcagcag gaagaaaaaa ccttcaggat   2580

tttgctgctt gtggaataga cagaatgaat tatgacagct acttggctca gactggtaaa   2640

tcccccgcag gagtgaatct tttatcattt gcatatgatc tagaagcaaa agcaaacagt   2700

ttgcccccag gaaatttgag gaactccctg aaaagagatg cacaaactat taaaacaatt   2760

caccagcaac gagtccttcc tatagaacaa tcactgagca ctctatacca aagcgtcaag   2820

atacttcaac gcacagggaa tggattgttg gagagagtaa ctaggattct agcttctctg   2880

gattttgctc agaacttcat cacaaacaat acttcctctg ttattattga ggaaactaag   2940

aagtatggga gaacaataat aggatatttt gaacattatc tgcagtggat cgagttctct   3000

atcagtgaga aagtggcatc gtgcaaacct gtggccaccg ctctagatac tgctgttgat   3060

gtctttctgt gtagctacat tatcgacccc ttgaatttgt tttggtttgg cataggaaaa   3120

gctactgtat ttttacttcc ggctctaatt tttgcggtaa aactggctaa gtactatcgt   3180

cgaatggatt cggaggacgt gtacgatgat gttgaaacta tacccatgaa aaatatggaa   3240

aatggtaata atggttatca taaagatcat gtatatggta ttcacaatcc tgttatgaca   3300

agcccatcac aacattgata gctgatgttg aaactgcttg agcatcagga tactcaaagt   3360

ggaaaggatc acagattttt ggtagtttct gggtctacaa ggactttcca aatccaggag   3420

caacgccagt ggcaacgtag tgactcaggc gggcaccaag gcaacggcac cattggtctc   3480

tgggtagtgc tttaagaatg aacacaatca cgttatagtc catggtccat cactattcaa   3540

ggatgactcc ctcccttcct gtctattttt gttttttact tttttacact gagtttctat   3600

ttagacacta caacatatgg ggtgtttgtt cccattggat gcatttctat caaaactcta   3660

tcaaatgtga tggctagatt ctaacatatt gccatgtgtg gagtgtgctg aacacacacc   3720

agtttacagg aaagatgcat tttgtgtaca gtaaacggtg tatatacctt ttgttaccac   3780

agagtttttt aaacaaatga gtattatagg actttcttct aaatgagcta aataagtcac   3840

cattgacttc ttggtgctgt tgaaaataat ccattttcac taaaagtgtg tgaaacctac   3900

agcatattct tcacgcagag attttcatct attatacttt atcaaagatt ggccatgttc   3960

cacttggaaa tggcatgcaa aagcaatcat agagaaacct gcgtaactcc atctgacaaa   4020

ttcaaaagag agagagagat cttgagagag aaatgctgtt cgttcaaaag tggagttgtt   4080

ttaacagatg ccaattacgg tgtacagttt aacagagttt tctgttgcat tacgataaac   4140

attaattgga gtgcagctaa catgagtatc atcagactag tatcaagtgt tctaaaatga   4200

aatatgagaa gatcctgtca caattcttag atctggtgtc cagcatggat gaaacctttg   4260

agtttggtcc ctaaatttgc atgaaagcac aaggtaaata ttcatttgct tcaggagttt   4320

catgttggat ctgtcattat caaaagtgat cagcaatgaa gaactggtcg gacaaaattt   4380

aacgttgatg taatgaaatt ccagatgtag gcattccccc caggtctttt catgtgcaga   4440

ttgcagttct gattcatttg aataaaaagg aacttggaaa acatg                   4485


<210>  2397
<211>  865
<212>  PRT
<213>  Homo sapiens

<400>  2397

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Pro Glu Thr Val 
                85                  90                  95


Ile Leu Gly Leu Lys Ile Val Tyr Tyr Glu Ala Gly Ile Ile Leu Cys 
            100                 105                 110


Cys Val Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly Tyr 
        115                 120                 125


Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His 
    130                 135                 140


Gln Arg Gln Lys Glu Asn Gly Pro Phe Leu Arg Lys Cys Phe Ala Ile 
145                 150                 155                 160


Ser Leu Leu Val Ile Cys Ile Ile Ile Ser Ile Gly Ile Phe Tyr Gly 
                165                 170                 175


Phe Val Ala Asn His Gln Val Arg Thr Arg Ile Lys Arg Ser Arg Lys 
            180                 185                 190


Leu Ala Asp Ser Asn Phe Lys Asp Leu Arg Thr Leu Leu Asn Glu Thr 
        195                 200                 205


Pro Glu Gln Ile Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp 
    210                 215                 220


Lys Ala Phe Thr Asp Leu Asn Ser Ile Asn Ser Val Leu Gly Gly Gly 
225                 230                 235                 240


Ile Leu Asp Arg Leu Arg Pro Asn Ile Ile Pro Val Leu Asp Glu Ile 
                245                 250                 255


Lys Ser Met Ala Thr Ala Ile Lys Glu Thr Lys Glu Ala Leu Glu Asn 
            260                 265                 270


Met Asn Ser Thr Leu Lys Ser Leu His Gln Gln Ser Thr Gln Leu Ser 
        275                 280                 285


Ser Ser Leu Thr Ser Val Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp 
    290                 295                 300


Pro Leu Cys Leu Val His Pro Ser Ser Glu Thr Cys Asn Ser Ile Arg 
305                 310                 315                 320


Leu Ser Leu Ser Gln Leu Asn Ser Asn Pro Glu Leu Arg Gln Leu Pro 
                325                 330                 335


Pro Val Asp Ala Glu Leu Asp Asn Val Asn Asn Val Leu Arg Thr Asp 
            340                 345                 350


Leu Asp Gly Leu Val Gln Gln Gly Tyr Gln Ser Leu Asn Asp Ile Pro 
        355                 360                 365


Asp Arg Val Gln Arg Gln Thr Thr Thr Val Val Ala Gly Ile Lys Arg 
    370                 375                 380


Val Leu Asn Ser Ile Gly Ser Asp Ile Asp Asn Val Thr Gln Arg Leu 
385                 390                 395                 400


Pro Ile Gln Asp Ile Leu Ser Ala Phe Ser Val Tyr Val Asn Asn Thr 
                405                 410                 415


Glu Ser Tyr Ile His Arg Asn Leu Pro Thr Leu Glu Glu Tyr Asp Ser 
            420                 425                 430


Tyr Trp Trp Leu Gly Gly Leu Val Ile Cys Ser Leu Leu Thr Leu Ile 
        435                 440                 445


Val Ile Phe Tyr Tyr Leu Gly Leu Leu Cys Gly Val Cys Gly Tyr Asp 
    450                 455                 460


Arg His Ala Thr Pro Thr Thr Arg Gly Cys Val Ser Asn Thr Gly Gly 
465                 470                 475                 480


Val Phe Leu Met Val Gly Val Gly Leu Ser Phe Leu Phe Cys Trp Ile 
                485                 490                 495


Leu Met Ile Ile Val Val Leu Thr Phe Val Phe Gly Ala Asn Val Glu 
            500                 505                 510


Lys Leu Ile Cys Glu Pro Tyr Thr Ser Lys Glu Leu Phe Arg Val Leu 
        515                 520                 525


Asp Thr Pro Tyr Leu Leu Asn Glu Asp Trp Glu Tyr Tyr Leu Ser Gly 
    530                 535                 540


Lys Leu Phe Asn Lys Ser Lys Met Lys Leu Thr Phe Glu Gln Val Tyr 
545                 550                 555                 560


Ser Asp Cys Lys Lys Asn Arg Gly Thr Tyr Gly Thr Leu His Leu Gln 
                565                 570                 575


Asn Ser Phe Asn Ile Ser Glu His Leu Asn Ile Asn Glu His Thr Gly 
            580                 585                 590


Ser Ile Ser Ser Glu Leu Glu Ser Leu Lys Val Asn Leu Asn Ile Phe 
        595                 600                 605


Leu Leu Gly Ala Ala Gly Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys 
    610                 615                 620


Gly Ile Asp Arg Met Asn Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys 
625                 630                 635                 640


Ser Pro Ala Gly Val Asn Leu Leu Ser Phe Ala Tyr Asp Leu Glu Ala 
                645                 650                 655


Lys Ala Asn Ser Leu Pro Pro Gly Asn Leu Arg Asn Ser Leu Lys Arg 
            660                 665                 670


Asp Ala Gln Thr Ile Lys Thr Ile His Gln Gln Arg Val Leu Pro Ile 
        675                 680                 685


Glu Gln Ser Leu Ser Thr Leu Tyr Gln Ser Val Lys Ile Leu Gln Arg 
    690                 695                 700


Thr Gly Asn Gly Leu Leu Glu Arg Val Thr Arg Ile Leu Ala Ser Leu 
705                 710                 715                 720


Asp Phe Ala Gln Asn Phe Ile Thr Asn Asn Thr Ser Ser Val Ile Ile 
                725                 730                 735


Glu Glu Thr Lys Lys Tyr Gly Arg Thr Ile Ile Gly Tyr Phe Glu His 
            740                 745                 750


Tyr Leu Gln Trp Ile Glu Phe Ser Ile Ser Glu Lys Val Ala Ser Cys 
        755                 760                 765


Lys Pro Val Ala Thr Ala Leu Asp Thr Ala Val Asp Val Phe Leu Cys 
    770                 775                 780


Ser Tyr Ile Ile Asp Pro Leu Asn Leu Phe Trp Phe Gly Ile Gly Lys 
785                 790                 795                 800


Ala Thr Val Phe Leu Leu Pro Ala Leu Ile Phe Ala Val Lys Leu Ala 
                805                 810                 815


Lys Tyr Tyr Arg Arg Met Asp Ser Glu Asp Val Tyr Asp Asp Val Glu 
            820                 825                 830


Thr Ile Pro Met Lys Asn Met Glu Asn Gly Asn Asn Gly Tyr His Lys 
        835                 840                 845


Asp His Val Tyr Gly Ile His Asn Pro Val Met Thr Ser Pro Ser Gln 
    850                 855                 860


His 
865


<210>  2398
<211>  4278
<212>  DNA
<213>  Homo sapiens

<400>  2398
aaattgcatt gggattaggc aacagaaggg tctaatgcgg ccgggatgag acaggagagt     60

ttttaggagg gtagctgcat tctaagtaag ggactctgcg gggggaaaag aggcgcaagc    120

gttgcaagaa gggagtgcag ggggttgagc aggcacctct acaggaaatg gatgctgtcc    180

aggtgctggt gggcgcccca gggctacgtg gcgaagcagc tcagccggtc caatcagagt    240

gcgtccaggg ctcgggtttc gcgatcttta agtgactgag gcagatcccc acgcggcacc    300

tggccatgct ctcagctctc ccgccgcggg atggtgcctt gagtgaatga cccccttgga    360

gaacattctt ccgcatccct cgcctcaagc cagcctcaga cagaaaactg aagattcagc    420

agatccagtg cttcctgctc ctcttctgcc caggaacacg cttgccttcc ccaaggcttc    480

cagaagctct gaggcaggag gcaccaagtt ctacctcatg tttggaggat cttgctagct    540

atggccctcg tactcggctc cctgttgctg ctggggctgt gcgggaactc cttttcagga    600

gggcagcctt catccacaga tgctcctaag gcttggaatt atgaattgcc tgcaacaaat    660

tatgagaccc aagactccca taaagctgga cccattggca ttctctttga actagtgcat    720

atctttctct atgtggtaca gccgcgtgat ttcccagaag atactttgag aaaattctta    780

cagaaggcat atgaatccaa aattgattat gacaagattg tctactatga agcagggatt    840

attctatgct gtgtcctggg gctgctgttt attattctga tgcctctggt ggggtatttc    900

ttttgtatgt gtcgttgctg taacaaatgt ggtggagaaa tgcaccagcg acagaaggaa    960

aatgggccct tcctgaggaa atgctttgca atctccctgt tggtgatttg tataataata   1020

agcattggca tcttctatgg ttttgtggca aatcaccagg taagaacccg gatcaaaagg   1080

agtcggaaac tggcagatag caatttcaag gacttgcgaa ctctcttgaa tgaaactcca   1140

gagcaaatca aatatatatt ggcccagtac aacactacca aggacaaggc gttcacagat   1200

ctgaacagta tcaattcagt gctaggaggc ggaattcttg accgactgag acccaacatc   1260

atccctgttc ttgatgagat taagtccatg gcaacagcga tcaaggagac caaagaggcg   1320

ttggagaaca tgaacagcac cttgaagagc ttgcaccaac aaagtacaca gcttagcagc   1380

agtctgacca gcgtgaaaac tagcctgcgg tcatctctca atgaccctct gtgcttggtg   1440

catccatcaa gtgaaacctg caacagcatc agattgtctc taagccagct gaatagcaac   1500

cctgaactga ggcagcttcc acccgtggat gcagaacttg acaacgttaa taacgttctt   1560

aggacagatt tggatggcct ggtccaacag ggctatcaat cccttaatga tatacctgac   1620

agagtacaac gccaaaccac gactgtcgta gcaggtatca aaagggtctt gaattccatt   1680

ggttcagata tcgacaatgt aactcagcgt cttcctattc aggatatact ctcagcattc   1740

tctgtttatg ttaataacac tgaaagttac atccacagaa atttacctac attggaagag   1800

tatgattcat actggtggct gggtggcctg gtcatctgct ctctgctgac cctcatcgtg   1860

attttttact acctgggctt actgtgtggc gtgtgcggct atgacaggca tgccaccccg   1920

accacccgag gctgtgtctc caacaccgga ggcgtcttcc tcatggttgg agttggatta   1980

agtttcctct tttgctggat attgatgatc attgtggttc ttacctttgt ctttggtgca   2040

aatgtggaaa aactgatctg tgaaccttac acgagcaagg aattattccg ggttttggat   2100

acaccctact tactaaatga agactgggaa tactatctct ctgggaagct atttaataaa   2160

tcaaaaatga agctcacttt tgaacaagtt tacagtgact gcaaaaaaaa tagaggcact   2220

tacggcactc ttcacctgca gaacagcttc aatatcagtg aacatctcaa cattaatgag   2280

catactggaa gcataagcag tgaattggaa agtctgaagg taaatcttaa tatctttctg   2340

ttgggtgcag caggaagaaa aaaccttcag gattttgctg cttgtggaat agacagaatg   2400

aattatgaca gctacttggc tcagactggt aaatcccccg caggagtgaa tcttttatca   2460

tttgcatatg atctagaagc aaaagcaaac agtttgcccc caggaaattt gaggaactcc   2520

ctgaaaagag atgcacaaac tattaaaaca attcaccagc aacgagtcct tcctatagaa   2580

caatcactga gcactctata ccaaagcgtc aagatacttc aacgcacagg gaatggattg   2640

ttggagagag taactaggat tctagcttct ctggattttg ctcagaactt catcacaaac   2700

aatacttcct ctgttattat tgaggaaact aagaagtatg ggagaacaat aataggatat   2760

tttgaacatt atctgcagtg gatcgagttc tctatcagtg agaaagtggc atcgtgcaaa   2820

cctgtggcca ccgctctaga tactgctgtt gatgtctttc tgtgtagcta cattatcgac   2880

cccttgaatt tgttttggtt tggcatagga aaagctactg tatttttact tccggctcta   2940

atttttgcgg taaaactggc taagtactat cgtcgaatgg attcggagga cgtgtacgat   3000

gatgttgaaa ctatacccat gaaaaatatg gaaaatggta ataatggtta tcataaagat   3060

catgtatatg gtattcacaa tcctgttatg acaagcccat cacaacattg atagctgatg   3120

ttgaaactgc ttgagcatca ggatactcaa agtggaaagg atcacagatt tttggtagtt   3180

tctgggtcta caaggacttt ccaaatccag gagcaacgcc agtggcaacg tagtgactca   3240

ggcgggcacc aaggcaacgg caccattggt ctctgggtag tgctttaaga atgaacacaa   3300

tcacgttata gtccatggtc catcactatt caaggatgac tccctccctt cctgtctatt   3360

tttgtttttt acttttttac actgagtttc tatttagaca ctacaacata tggggtgttt   3420

gttcccattg gatgcatttc tatcaaaact ctatcaaatg tgatggctag attctaacat   3480

attgccatgt gtggagtgtg ctgaacacac accagtttac aggaaagatg cattttgtgt   3540

acagtaaacg gtgtatatac cttttgttac cacagagttt tttaaacaaa tgagtattat   3600

aggactttct tctaaatgag ctaaataagt caccattgac ttcttggtgc tgttgaaaat   3660

aatccatttt cactaaaagt gtgtgaaacc tacagcatat tcttcacgca gagattttca   3720

tctattatac tttatcaaag attggccatg ttccacttgg aaatggcatg caaaagcaat   3780

catagagaaa cctgcgtaac tccatctgac aaattcaaaa gagagagaga gatcttgaga   3840

gagaaatgct gttcgttcaa aagtggagtt gttttaacag atgccaatta cggtgtacag   3900

tttaacagag ttttctgttg cattacgata aacattaatt ggagtgcagc taacatgagt   3960

atcatcagac tagtatcaag tgttctaaaa tgaaatatga gaagatcctg tcacaattct   4020

tagatctggt gtccagcatg gatgaaacct ttgagtttgg tccctaaatt tgcatgaaag   4080

cacaaggtaa atattcattt gcttcaggag tttcatgttg gatctgtcat tatcaaaagt   4140

gatcagcaat gaagaactgg tcggacaaaa tttaacgttg atgtaatgaa attccagatg   4200

taggcattcc ccccaggtct tttcatgtgc agattgcagt tctgattcat ttgaataaaa   4260

aggaacttgg aaaacatg                                                 4278


<210>  2399
<211>  856
<212>  PRT
<213>  Homo sapiens

<400>  2399

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Ile Val Tyr Tyr 
                85                  90                  95


Glu Ala Gly Ile Ile Leu Cys Cys Val Leu Gly Leu Leu Phe Ile Ile 
            100                 105                 110


Leu Met Pro Leu Val Gly Tyr Phe Phe Cys Met Cys Arg Cys Cys Asn 
        115                 120                 125


Lys Cys Gly Gly Glu Met His Gln Arg Gln Lys Glu Asn Gly Pro Phe 
    130                 135                 140


Leu Arg Lys Cys Phe Ala Ile Ser Leu Leu Val Ile Cys Ile Ile Ile 
145                 150                 155                 160


Ser Ile Gly Ile Phe Tyr Gly Phe Val Ala Asn His Gln Val Arg Thr 
                165                 170                 175


Arg Ile Lys Arg Ser Arg Lys Leu Ala Asp Ser Asn Phe Lys Asp Leu 
            180                 185                 190


Arg Thr Leu Leu Asn Glu Thr Pro Glu Gln Ile Lys Tyr Ile Leu Ala 
        195                 200                 205


Gln Tyr Asn Thr Thr Lys Asp Lys Ala Phe Thr Asp Leu Asn Ser Ile 
    210                 215                 220


Asn Ser Val Leu Gly Gly Gly Ile Leu Asp Arg Leu Arg Pro Asn Ile 
225                 230                 235                 240


Ile Pro Val Leu Asp Glu Ile Lys Ser Met Ala Thr Ala Ile Lys Glu 
                245                 250                 255


Thr Lys Glu Ala Leu Glu Asn Met Asn Ser Thr Leu Lys Ser Leu His 
            260                 265                 270


Gln Gln Ser Thr Gln Leu Ser Ser Ser Leu Thr Ser Val Lys Thr Ser 
        275                 280                 285


Leu Arg Ser Ser Leu Asn Asp Pro Leu Cys Leu Val His Pro Ser Ser 
    290                 295                 300


Glu Thr Cys Asn Ser Ile Arg Leu Ser Leu Ser Gln Leu Asn Ser Asn 
305                 310                 315                 320


Pro Glu Leu Arg Gln Leu Pro Pro Val Asp Ala Glu Leu Asp Asn Val 
                325                 330                 335


Asn Asn Val Leu Arg Thr Asp Leu Asp Gly Leu Val Gln Gln Gly Tyr 
            340                 345                 350


Gln Ser Leu Asn Asp Ile Pro Asp Arg Val Gln Arg Gln Thr Thr Thr 
        355                 360                 365


Val Val Ala Gly Ile Lys Arg Val Leu Asn Ser Ile Gly Ser Asp Ile 
    370                 375                 380


Asp Asn Val Thr Gln Arg Leu Pro Ile Gln Asp Ile Leu Ser Ala Phe 
385                 390                 395                 400


Ser Val Tyr Val Asn Asn Thr Glu Ser Tyr Ile His Arg Asn Leu Pro 
                405                 410                 415


Thr Leu Glu Glu Tyr Asp Ser Tyr Trp Trp Leu Gly Gly Leu Val Ile 
            420                 425                 430


Cys Ser Leu Leu Thr Leu Ile Val Ile Phe Tyr Tyr Leu Gly Leu Leu 
        435                 440                 445


Cys Gly Val Cys Gly Tyr Asp Arg His Ala Thr Pro Thr Thr Arg Gly 
    450                 455                 460


Cys Val Ser Asn Thr Gly Gly Val Phe Leu Met Val Gly Val Gly Leu 
465                 470                 475                 480


Ser Phe Leu Phe Cys Trp Ile Leu Met Ile Ile Val Val Leu Thr Phe 
                485                 490                 495


Val Phe Gly Ala Asn Val Glu Lys Leu Ile Cys Glu Pro Tyr Thr Ser 
            500                 505                 510


Lys Glu Leu Phe Arg Val Leu Asp Thr Pro Tyr Leu Leu Asn Glu Asp 
        515                 520                 525


Trp Glu Tyr Tyr Leu Ser Gly Lys Leu Phe Asn Lys Ser Lys Met Lys 
    530                 535                 540


Leu Thr Phe Glu Gln Val Tyr Ser Asp Cys Lys Lys Asn Arg Gly Thr 
545                 550                 555                 560


Tyr Gly Thr Leu His Leu Gln Asn Ser Phe Asn Ile Ser Glu His Leu 
                565                 570                 575


Asn Ile Asn Glu His Thr Gly Ser Ile Ser Ser Glu Leu Glu Ser Leu 
            580                 585                 590


Lys Val Asn Leu Asn Ile Phe Leu Leu Gly Ala Ala Gly Arg Lys Asn 
        595                 600                 605


Leu Gln Asp Phe Ala Ala Cys Gly Ile Asp Arg Met Asn Tyr Asp Ser 
    610                 615                 620


Tyr Leu Ala Gln Thr Gly Lys Ser Pro Ala Gly Val Asn Leu Leu Ser 
625                 630                 635                 640


Phe Ala Tyr Asp Leu Glu Ala Lys Ala Asn Ser Leu Pro Pro Gly Asn 
                645                 650                 655


Leu Arg Asn Ser Leu Lys Arg Asp Ala Gln Thr Ile Lys Thr Ile His 
            660                 665                 670


Gln Gln Arg Val Leu Pro Ile Glu Gln Ser Leu Ser Thr Leu Tyr Gln 
        675                 680                 685


Ser Val Lys Ile Leu Gln Arg Thr Gly Asn Gly Leu Leu Glu Arg Val 
    690                 695                 700


Thr Arg Ile Leu Ala Ser Leu Asp Phe Ala Gln Asn Phe Ile Thr Asn 
705                 710                 715                 720


Asn Thr Ser Ser Val Ile Ile Glu Glu Thr Lys Lys Tyr Gly Arg Thr 
                725                 730                 735


Ile Ile Gly Tyr Phe Glu His Tyr Leu Gln Trp Ile Glu Phe Ser Ile 
            740                 745                 750


Ser Glu Lys Val Ala Ser Cys Lys Pro Val Ala Thr Ala Leu Asp Thr 
        755                 760                 765


Ala Val Asp Val Phe Leu Cys Ser Tyr Ile Ile Asp Pro Leu Asn Leu 
    770                 775                 780


Phe Trp Phe Gly Ile Gly Lys Ala Thr Val Phe Leu Leu Pro Ala Leu 
785                 790                 795                 800


Ile Phe Ala Val Lys Leu Ala Lys Tyr Tyr Arg Arg Met Asp Ser Glu 
                805                 810                 815


Asp Val Tyr Asp Asp Val Glu Thr Ile Pro Met Lys Asn Met Glu Asn 
            820                 825                 830


Gly Asn Asn Gly Tyr His Lys Asp His Val Tyr Gly Ile His Asn Pro 
        835                 840                 845


Val Met Thr Ser Pro Ser Gln His 
    850                 855


<210>  2400
<211>  4305
<212>  DNA
<213>  Homo sapiens

<400>  2400
aaattgcatt gggattaggc aacagaaggg tctaatgcgg ccgggatgag acaggagagt     60

ttttaggagg gtagctgcat tctaagtaag ggactctgcg gggggaaaag aggcgcaagc    120

gttgcaagaa gggagtgcag ggggttgagc aggcacctct acaggaaatg gatgctgtcc    180

aggtgctggt gggcgcccca gggctacgtg gcgaagcagc tcagccggtc caatcagagt    240

gcgtccaggg ctcgggtttc gcgatcttta agtgactgag gcagatcccc acgcggcacc    300

tggccatgct ctcagctctc ccgccgcggg atggtgcctt gagtgaatga cccccttgga    360

gaacattctt ccgcatccct cgcctcaagc cagcctcaga cagaaaactg aagattcagc    420

agatccagtg cttcctgctc ctcttctgcc caggaacacg cttgccttcc ccaaggcttc    480

cagaagctct gaggcaggag gcaccaagtt ctacctcatg tttggaggat cttgctagct    540

atggccctcg tactcggctc cctgttgctg ctggggctgt gcgggaactc cttttcagga    600

gggcagcctt catccacaga tgctcctaag gcttggaatt atgaattgcc tgcaacaaat    660

tatgagaccc aagactccca taaagctgga cccattggca ttctctttga actagtgcat    720

atctttctct atgtggtaca gccgcgtgat ttcccagaag atactttgag aaaattctta    780

cagaaggcat atgaatccaa aattgattat gacaagccag aaactgtaat cttaggtcta    840

aagattgtct actatgaagc agggattatt ctatgctgtg tcctggggct gctgtttatt    900

attctgatgc ctctggtggg gtatttcttt tgtatgtgtc gttgctgtaa caaatgtggt    960

ggagaaatgc accagcgaca gaaggaaaat gggcccttcc tgaggaaatg ctttgcaatc   1020

tccctgttgg tgatttgtat aataataagc attggcatct tctatggttt tgtggcaaat   1080

caccaggtaa gaacccggat caaaaggagt cggaaactgg cagatagcaa tttcaaggac   1140

ttgcgaactc tcttgaatga aactccagag caaatcaaat atatattggc ccagtacaac   1200

actaccaagg acaaggcgtt cacagatctg aacagtatca attcagtgct aggaggcgga   1260

attcttgacc gactgagacc caacatcatc cctgttcttg atgagattaa gtccatggca   1320

acagcgatca aggagaccaa agaggcgttg gagaacatga acagcacctt gaagagcttg   1380

caccaacaaa gtacacagct tagcagcagt ctgaccagcg tgaaaactag cctgcggtca   1440

tctctcaatg accctctgtg cttggtgcat ccatcaagtg aaacctgcaa cagcatcaga   1500

ttgtctctaa gccagctgaa tagcaaccct gaactgaggc agcttccacc cgtggatgca   1560

gaacttgaca acgttaataa cgttcttagg acagatttgg atggcctggt ccaacagggc   1620

tatcaatccc ttaatgatat acctgacaga gtacaacgcc aaaccacgac tgtcgtagca   1680

ggtatcaaaa gggtcttgaa ttccattggt tcagatatcg acaatgtaac tcagcgtctt   1740

cctattcagg atatactctc agcattctct gtttatgtta ataacactga aagttacatc   1800

cacagaaatt tacctacatt ggaagagtat gattcatact ggtggctggg tggcctggtc   1860

atctgctctc tgctgaccct catcgtgatt ttttactacc tgggcttact gtgtggcgtg   1920

tgcggctatg acaggcatgc caccccgacc acccgaggct gtgtctccaa caccggaggc   1980

gtcttcctca tggttggagt tggattaagt ttcctctttt gctggatatt gatgatcatt   2040

gtggttctta cctttgtctt tggtgcaaat gtggaaaaac tgatctgtga accttacacg   2100

agcaaggaat tattccgggt tttggataca ccctacttac taaatgaaga ctgggaatac   2160

tatctctctg ggaagctatt taataaatca aaaatgaagc tcacttttga acaagtttac   2220

agtgactgca aaaaaaatag aggcacttac ggcactcttc acctgcagaa cagcttcaat   2280

atcagtgaac atctcaacat taatgagcat actggaagca taagcagtga attggaaagt   2340

ctgaaggtaa atcttaatat ctttctgttg ggtgcagcag gaagaaaaaa ccttcaggat   2400

tttgctgctt gtggaataga cagaatgaat tatgacagct acttggctca gactggtaaa   2460

tcccccgcag gagtgaatct tttatcattt gcatatgatc tagaagcaaa agcaaacagt   2520

ttgcccccag gaaatttgag gaactccctg aaaagagatg cacaaactat taaaacaatt   2580

caccagcaac gagtccttcc tatagaacaa tcactgagca ctctatacca aagcgtcaag   2640

atacttcaac gcacagggaa tggattgttg gagagagtaa ctaggattct agcttctctg   2700

gattttgctc agaacttcat cacaaacaat acttcctctg ttattattga ggaaactaag   2760

aagtatggga gaacaataat aggatatttt gaacattatc tgcagtggat cgagttctct   2820

atcagtgaga aagtggcatc gtgcaaacct gtggccaccg ctctagatac tgctgttgat   2880

gtctttctgt gtagctacat tatcgacccc ttgaatttgt tttggtttgg cataggaaaa   2940

gctactgtat ttttacttcc ggctctaatt tttgcggtaa aactggctaa gtactatcgt   3000

cgaatggatt cggaggacgt gtacgatgat gttgaaacta tacccatgaa aaatatggaa   3060

aatggtaata atggttatca taaagatcat gtatatggta ttcacaatcc tgttatgaca   3120

agcccatcac aacattgata gctgatgttg aaactgcttg agcatcagga tactcaaagt   3180

ggaaaggatc acagattttt ggtagtttct gggtctacaa ggactttcca aatccaggag   3240

caacgccagt ggcaacgtag tgactcaggc gggcaccaag gcaacggcac cattggtctc   3300

tgggtagtgc tttaagaatg aacacaatca cgttatagtc catggtccat cactattcaa   3360

ggatgactcc ctcccttcct gtctattttt gttttttact tttttacact gagtttctat   3420

ttagacacta caacatatgg ggtgtttgtt cccattggat gcatttctat caaaactcta   3480

tcaaatgtga tggctagatt ctaacatatt gccatgtgtg gagtgtgctg aacacacacc   3540

agtttacagg aaagatgcat tttgtgtaca gtaaacggtg tatatacctt ttgttaccac   3600

agagtttttt aaacaaatga gtattatagg actttcttct aaatgagcta aataagtcac   3660

cattgacttc ttggtgctgt tgaaaataat ccattttcac taaaagtgtg tgaaacctac   3720

agcatattct tcacgcagag attttcatct attatacttt atcaaagatt ggccatgttc   3780

cacttggaaa tggcatgcaa aagcaatcat agagaaacct gcgtaactcc atctgacaaa   3840

ttcaaaagag agagagagat cttgagagag aaatgctgtt cgttcaaaag tggagttgtt   3900

ttaacagatg ccaattacgg tgtacagttt aacagagttt tctgttgcat tacgataaac   3960

attaattgga gtgcagctaa catgagtatc atcagactag tatcaagtgt tctaaaatga   4020

aatatgagaa gatcctgtca caattcttag atctggtgtc cagcatggat gaaacctttg   4080

agtttggtcc ctaaatttgc atgaaagcac aaggtaaata ttcatttgct tcaggagttt   4140

catgttggat ctgtcattat caaaagtgat cagcaatgaa gaactggtcg gacaaaattt   4200

aacgttgatg taatgaaatt ccagatgtag gcattccccc caggtctttt catgtgcaga   4260

ttgcagttct gattcatttg aataaaaagg aacttggaaa acatg                   4305


<210>  2401
<211>  865
<212>  PRT
<213>  Homo sapiens

<400>  2401

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Pro Glu Thr Val 
                85                  90                  95


Ile Leu Gly Leu Lys Ile Val Tyr Tyr Glu Ala Gly Ile Ile Leu Cys 
            100                 105                 110


Cys Val Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly Tyr 
        115                 120                 125


Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His 
    130                 135                 140


Gln Arg Gln Lys Glu Asn Gly Pro Phe Leu Arg Lys Cys Phe Ala Ile 
145                 150                 155                 160


Ser Leu Leu Val Ile Cys Ile Ile Ile Ser Ile Gly Ile Phe Tyr Gly 
                165                 170                 175


Phe Val Ala Asn His Gln Val Arg Thr Arg Ile Lys Arg Ser Arg Lys 
            180                 185                 190


Leu Ala Asp Ser Asn Phe Lys Asp Leu Arg Thr Leu Leu Asn Glu Thr 
        195                 200                 205


Pro Glu Gln Ile Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp 
    210                 215                 220


Lys Ala Phe Thr Asp Leu Asn Ser Ile Asn Ser Val Leu Gly Gly Gly 
225                 230                 235                 240


Ile Leu Asp Arg Leu Arg Pro Asn Ile Ile Pro Val Leu Asp Glu Ile 
                245                 250                 255


Lys Ser Met Ala Thr Ala Ile Lys Glu Thr Lys Glu Ala Leu Glu Asn 
            260                 265                 270


Met Asn Ser Thr Leu Lys Ser Leu His Gln Gln Ser Thr Gln Leu Ser 
        275                 280                 285


Ser Ser Leu Thr Ser Val Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp 
    290                 295                 300


Pro Leu Cys Leu Val His Pro Ser Ser Glu Thr Cys Asn Ser Ile Arg 
305                 310                 315                 320


Leu Ser Leu Ser Gln Leu Asn Ser Asn Pro Glu Leu Arg Gln Leu Pro 
                325                 330                 335


Pro Val Asp Ala Glu Leu Asp Asn Val Asn Asn Val Leu Arg Thr Asp 
            340                 345                 350


Leu Asp Gly Leu Val Gln Gln Gly Tyr Gln Ser Leu Asn Asp Ile Pro 
        355                 360                 365


Asp Arg Val Gln Arg Gln Thr Thr Thr Val Val Ala Gly Ile Lys Arg 
    370                 375                 380


Val Leu Asn Ser Ile Gly Ser Asp Ile Asp Asn Val Thr Gln Arg Leu 
385                 390                 395                 400


Pro Ile Gln Asp Ile Leu Ser Ala Phe Ser Val Tyr Val Asn Asn Thr 
                405                 410                 415


Glu Ser Tyr Ile His Arg Asn Leu Pro Thr Leu Glu Glu Tyr Asp Ser 
            420                 425                 430


Tyr Trp Trp Leu Gly Gly Leu Val Ile Cys Ser Leu Leu Thr Leu Ile 
        435                 440                 445


Val Ile Phe Tyr Tyr Leu Gly Leu Leu Cys Gly Val Cys Gly Tyr Asp 
    450                 455                 460


Arg His Ala Thr Pro Thr Thr Arg Gly Cys Val Ser Asn Thr Gly Gly 
465                 470                 475                 480


Val Phe Leu Met Val Gly Val Gly Leu Ser Phe Leu Phe Cys Trp Ile 
                485                 490                 495


Leu Met Ile Ile Val Val Leu Thr Phe Val Phe Gly Ala Asn Val Glu 
            500                 505                 510


Lys Leu Ile Cys Glu Pro Tyr Thr Ser Lys Glu Leu Phe Arg Val Leu 
        515                 520                 525


Asp Thr Pro Tyr Leu Leu Asn Glu Asp Trp Glu Tyr Tyr Leu Ser Gly 
    530                 535                 540


Lys Leu Phe Asn Lys Ser Lys Met Lys Leu Thr Phe Glu Gln Val Tyr 
545                 550                 555                 560


Ser Asp Cys Lys Lys Asn Arg Gly Thr Tyr Gly Thr Leu His Leu Gln 
                565                 570                 575


Asn Ser Phe Asn Ile Ser Glu His Leu Asn Ile Asn Glu His Thr Gly 
            580                 585                 590


Ser Ile Ser Ser Glu Leu Glu Ser Leu Lys Val Asn Leu Asn Ile Phe 
        595                 600                 605


Leu Leu Gly Ala Ala Gly Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys 
    610                 615                 620


Gly Ile Asp Arg Met Asn Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys 
625                 630                 635                 640


Ser Pro Ala Gly Val Asn Leu Leu Ser Phe Ala Tyr Asp Leu Glu Ala 
                645                 650                 655


Lys Ala Asn Ser Leu Pro Pro Gly Asn Leu Arg Asn Ser Leu Lys Arg 
            660                 665                 670


Asp Ala Gln Thr Ile Lys Thr Ile His Gln Gln Arg Val Leu Pro Ile 
        675                 680                 685


Glu Gln Ser Leu Ser Thr Leu Tyr Gln Ser Val Lys Ile Leu Gln Arg 
    690                 695                 700


Thr Gly Asn Gly Leu Leu Glu Arg Val Thr Arg Ile Leu Ala Ser Leu 
705                 710                 715                 720


Asp Phe Ala Gln Asn Phe Ile Thr Asn Asn Thr Ser Ser Val Ile Ile 
                725                 730                 735


Glu Glu Thr Lys Lys Tyr Gly Arg Thr Ile Ile Gly Tyr Phe Glu His 
            740                 745                 750


Tyr Leu Gln Trp Ile Glu Phe Ser Ile Ser Glu Lys Val Ala Ser Cys 
        755                 760                 765


Lys Pro Val Ala Thr Ala Leu Asp Thr Ala Val Asp Val Phe Leu Cys 
    770                 775                 780


Ser Tyr Ile Ile Asp Pro Leu Asn Leu Phe Trp Phe Gly Ile Gly Lys 
785                 790                 795                 800


Ala Thr Val Phe Leu Leu Pro Ala Leu Ile Phe Ala Val Lys Leu Ala 
                805                 810                 815


Lys Tyr Tyr Arg Arg Met Asp Ser Glu Asp Val Tyr Asp Asp Val Glu 
            820                 825                 830


Thr Ile Pro Met Lys Asn Met Glu Asn Gly Asn Asn Gly Tyr His Lys 
        835                 840                 845


Asp His Val Tyr Gly Ile His Asn Pro Val Met Thr Ser Pro Ser Gln 
    850                 855                 860


His 
865


<210>  2402
<211>  4748
<212>  DNA
<213>  Homo sapiens

<400>  2402
tgggagcgaa tatggcttta tgctgttttt caaccgcttc agccactagc attggtactg     60

ctgcacacta aggatccaaa tgattgtttt tttgtttttt gttttgtttt gttttgtttt    120

gttttgtttt aaattgcatt gggattaggc aacagaaggg tctaatgcgg ccgggatgag    180

acaggagagt ttttaggagg gtagctgcat tctaagtaag ggactctgcg gggggaaaag    240

aggcgcaagc gttgcaagaa gggagtgcag ggggttgagc aggcacctct acaggaaatg    300

gatgctgtcc aggtgctggt gggcgcccca gggctacgtg gcgaagcagc tcagccggtc    360

caatcagagt gcgtccaggg ctcgggtttc gcgatcttta agtgactgag gcagatcccc    420

acgcggcacc tggccatgct ctcagctctc ccgccgcggt gagtatgttt aaggaatcct    480

ttccattacg gcggccccat acctaggtcc ccgtccggga cagaggaagc cgcaacgggt    540

ccccccgggc acccgggcct ttctcctgcc tcccgccacg tccgagggtc cggccgcagc    600

gccgcctgag cccctccgcg gccggcagtg ggaggcgggc tctccgaaag ccgtcgcggt    660

ggtcccagaa gccgggtcat aaataattca cgagccaggg tctggcgagc taagggaagg    720

gcggcggcag cggtgactag ggcgggagca ggagcgggag ccgggtgcac gggatggtgc    780

cttgagtgaa tgaccccctt ggagaacatt cttccgcatc cctcgcctca agccagcctc    840

agacagaaaa ctgaagattc agcagatcca gtgcttcctg ctcctcttct gcccaggaac    900

acgcttgcct tccccaaggc ttccagaagc tctgaggcag gaggcaccaa gttctacctc    960

atgtttggag gatcttgcta gctatggccc tcgtactcgg ctccctgttg ctgctggggc   1020

tgtgcgggaa ctccttttca ggagggcagc cttcatccac agatgctcct aaggcttgga   1080

attatgaatt gcctgcaaca aattatgaga cccaagactc ccataaagct ggacccattg   1140

gcattctctt tgaactagtg catatctttc tctatgtggt acagccgcgt gatttcccag   1200

aagatacttt gagaaaattc ttacagaagg catatgaatc caaaattgat tatgacaagc   1260

cagaaactgt aatcttaggt ctaaagattg tctactatga agcagggatt attctatgct   1320

gtgtcctggg gctgctgttt attattctga tgcctctggt ggggtatttc ttttgtatgt   1380

gtcgttgctg taacaaatgt ggtggagaaa tgcaccagcg acagaaggaa aatgggccct   1440

tcctgaggaa atgctttgca atctccctgt tggtgatttg tataataata agcattggca   1500

tcttctatgg ttttgtggca aatcaccagg taagaacccg gatcaaaagg agtcggaaac   1560

tggcagatag caatttcaag gacttgcgaa ctctcttgaa tgaaactcca gagcaaatca   1620

aatatatatt ggcccagtac aacactacca aggacaaggc gttcacagat ctgaacagta   1680

tcaattcagt gctaggaggc ggaattcttg accgactgag acccaacatc atccctgttc   1740

ttgatgagat taagtccatg gcaacagcga tcaaggagac caaagaggcg ttggagaaca   1800

tgaacagcac cttgaagagc ttgcaccaac aaagtacaca gcttagcagc agtctgacca   1860

gcgtgaaaac tagcctgcgg tcatctctca atgaccctct gtgcttggtg catccatcaa   1920

gtgaaacctg caacagcatc agattgtctc taagccagct gaatagcaac cctgaactga   1980

ggcagcttcc acccgtggat gcagaacttg acaacgttaa taacgttctt aggacagatt   2040

tggatggcct ggtccaacag ggctatcaat cccttaatga tatacctgac agagtacaac   2100

gccaaaccac gactgtcgta gcaggtatca aaagggtctt gaattccatt ggttcagata   2160

tcgacaatgt aactcagcgt cttcctattc aggatatact ctcagcattc tctgtttatg   2220

ttaataacac tgaaagttac atccacagaa atttacctac attggaagag tatgattcat   2280

actggtggct gggtggcctg gtcatctgct ctctgctgac cctcatcgtg attttttact   2340

acctgggctt actgtgtggc gtgtgcggct atgacaggca tgccaccccg accacccgag   2400

gctgtgtctc caacaccgga ggcgtcttcc tcatggttgg agttggatta agtttcctct   2460

tttgctggat attgatgatc attgtggttc ttacctttgt ctttggtgca aatgtggaaa   2520

aactgatctg tgaaccttac acgagcaagg aattattccg ggttttggat acaccctact   2580

tactaaatga agactgggaa tactatctct ctgggaagct atttaataaa tcaaaaatga   2640

agctcacttt tgaacaagtt tacagtgact gcaaaaaaaa tagaggcact tacggcactc   2700

ttcacctgca gaacagcttc aatatcagtg aacatctcaa cattaatgag catactggaa   2760

gcataagcag tgaattggaa agtctgaagg taaatcttaa tatctttctg ttgggtgcag   2820

caggaagaaa aaaccttcag gattttgctg cttgtggaat agacagaatg aattatgaca   2880

gctacttggc tcagactggt aaatcccccg caggagtgaa tcttttatca tttgcatatg   2940

atctagaagc aaaagcaaac agtttgcccc caggaaattt gaggaactcc ctgaaaagag   3000

atgcacaaac tattaaaaca attcaccagc aacgagtcct tcctatagaa caatcactga   3060

gcactctata ccaaagcgtc aagatacttc aacgcacagg gaatggattg ttggagagag   3120

taactaggat tctagcttct ctggattttg ctcagaactt catcacaaac aatacttcct   3180

ctgttattat tgaggaaact aagaagtatg ggagaacaat aataggatat tttgaacatt   3240

atctgcagtg gatcgagttc tctatcagtg agaaagtggc atcgtgcaaa cctgtggcca   3300

ccgctctaga tactgctgtt gatgtctttc tgtgtagcta cattatcgac cccttgaatt   3360

tgttttggtt tggcatagga aaagctactg tatttttact tccggctcta atttttgcgg   3420

taaaactggc taagtactat cgtcgaatgg attcggagga cgtgtacgat gatgttgaaa   3480

ctatacccat gaaaaatatg gaaaatggta ataatggtta tcataaagat catgtatatg   3540

gtattcacaa tcctgttatg acaagcccat cacaacattg atagctgatg ttgaaactgc   3600

ttgagcatca ggatactcaa agtggaaagg atcacagatt tttggtagtt tctgggtcta   3660

caaggacttt ccaaatccag gagcaacgcc agtggcaacg tagtgactca ggcgggcacc   3720

aaggcaacgg caccattggt ctctgggtag tgctttaaga atgaacacaa tcacgttata   3780

gtccatggtc catcactatt caaggatgac tccctccctt cctgtctatt tttgtttttt   3840

acttttttac actgagtttc tatttagaca ctacaacata tggggtgttt gttcccattg   3900

gatgcatttc tatcaaaact ctatcaaatg tgatggctag attctaacat attgccatgt   3960

gtggagtgtg ctgaacacac accagtttac aggaaagatg cattttgtgt acagtaaacg   4020

gtgtatatac cttttgttac cacagagttt tttaaacaaa tgagtattat aggactttct   4080

tctaaatgag ctaaataagt caccattgac ttcttggtgc tgttgaaaat aatccatttt   4140

cactaaaagt gtgtgaaacc tacagcatat tcttcacgca gagattttca tctattatac   4200

tttatcaaag attggccatg ttccacttgg aaatggcatg caaaagcaat catagagaaa   4260

cctgcgtaac tccatctgac aaattcaaaa gagagagaga gatcttgaga gagaaatgct   4320

gttcgttcaa aagtggagtt gttttaacag atgccaatta cggtgtacag tttaacagag   4380

ttttctgttg cattacgata aacattaatt ggagtgcagc taacatgagt atcatcagac   4440

tagtatcaag tgttctaaaa tgaaatatga gaagatcctg tcacaattct tagatctggt   4500

gtccagcatg gatgaaacct ttgagtttgg tccctaaatt tgcatgaaag cacaaggtaa   4560

atattcattt gcttcaggag tttcatgttg gatctgtcat tatcaaaagt gatcagcaat   4620

gaagaactgg tcggacaaaa tttaacgttg atgtaatgaa attccagatg taggcattcc   4680

ccccaggtct tttcatgtgc agattgcagt tctgattcat ttgaataaaa aggaacttgg   4740

aaaacatg                                                            4748


<210>  2403
<211>  865
<212>  PRT
<213>  Homo sapiens

<400>  2403

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Pro Glu Thr Val 
                85                  90                  95


Ile Leu Gly Leu Lys Ile Val Tyr Tyr Glu Ala Gly Ile Ile Leu Cys 
            100                 105                 110


Cys Val Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly Tyr 
        115                 120                 125


Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His 
    130                 135                 140


Gln Arg Gln Lys Glu Asn Gly Pro Phe Leu Arg Lys Cys Phe Ala Ile 
145                 150                 155                 160


Ser Leu Leu Val Ile Cys Ile Ile Ile Ser Ile Gly Ile Phe Tyr Gly 
                165                 170                 175


Phe Val Ala Asn His Gln Val Arg Thr Arg Ile Lys Arg Ser Arg Lys 
            180                 185                 190


Leu Ala Asp Ser Asn Phe Lys Asp Leu Arg Thr Leu Leu Asn Glu Thr 
        195                 200                 205


Pro Glu Gln Ile Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp 
    210                 215                 220


Lys Ala Phe Thr Asp Leu Asn Ser Ile Asn Ser Val Leu Gly Gly Gly 
225                 230                 235                 240


Ile Leu Asp Arg Leu Arg Pro Asn Ile Ile Pro Val Leu Asp Glu Ile 
                245                 250                 255


Lys Ser Met Ala Thr Ala Ile Lys Glu Thr Lys Glu Ala Leu Glu Asn 
            260                 265                 270


Met Asn Ser Thr Leu Lys Ser Leu His Gln Gln Ser Thr Gln Leu Ser 
        275                 280                 285


Ser Ser Leu Thr Ser Val Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp 
    290                 295                 300


Pro Leu Cys Leu Val His Pro Ser Ser Glu Thr Cys Asn Ser Ile Arg 
305                 310                 315                 320


Leu Ser Leu Ser Gln Leu Asn Ser Asn Pro Glu Leu Arg Gln Leu Pro 
                325                 330                 335


Pro Val Asp Ala Glu Leu Asp Asn Val Asn Asn Val Leu Arg Thr Asp 
            340                 345                 350


Leu Asp Gly Leu Val Gln Gln Gly Tyr Gln Ser Leu Asn Asp Ile Pro 
        355                 360                 365


Asp Arg Val Gln Arg Gln Thr Thr Thr Val Val Ala Gly Ile Lys Arg 
    370                 375                 380


Val Leu Asn Ser Ile Gly Ser Asp Ile Asp Asn Val Thr Gln Arg Leu 
385                 390                 395                 400


Pro Ile Gln Asp Ile Leu Ser Ala Phe Ser Val Tyr Val Asn Asn Thr 
                405                 410                 415


Glu Ser Tyr Ile His Arg Asn Leu Pro Thr Leu Glu Glu Tyr Asp Ser 
            420                 425                 430


Tyr Trp Trp Leu Gly Gly Leu Val Ile Cys Ser Leu Leu Thr Leu Ile 
        435                 440                 445


Val Ile Phe Tyr Tyr Leu Gly Leu Leu Cys Gly Val Cys Gly Tyr Asp 
    450                 455                 460


Arg His Ala Thr Pro Thr Thr Arg Gly Cys Val Ser Asn Thr Gly Gly 
465                 470                 475                 480


Val Phe Leu Met Val Gly Val Gly Leu Ser Phe Leu Phe Cys Trp Ile 
                485                 490                 495


Leu Met Ile Ile Val Val Leu Thr Phe Val Phe Gly Ala Asn Val Glu 
            500                 505                 510


Lys Leu Ile Cys Glu Pro Tyr Thr Ser Lys Glu Leu Phe Arg Val Leu 
        515                 520                 525


Asp Thr Pro Tyr Leu Leu Asn Glu Asp Trp Glu Tyr Tyr Leu Ser Gly 
    530                 535                 540


Lys Leu Phe Asn Lys Ser Lys Met Lys Leu Thr Phe Glu Gln Val Tyr 
545                 550                 555                 560


Ser Asp Cys Lys Lys Asn Arg Gly Thr Tyr Gly Thr Leu His Leu Gln 
                565                 570                 575


Asn Ser Phe Asn Ile Ser Glu His Leu Asn Ile Asn Glu His Thr Gly 
            580                 585                 590


Ser Ile Ser Ser Glu Leu Glu Ser Leu Lys Val Asn Leu Asn Ile Phe 
        595                 600                 605


Leu Leu Gly Ala Ala Gly Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys 
    610                 615                 620


Gly Ile Asp Arg Met Asn Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys 
625                 630                 635                 640


Ser Pro Ala Gly Val Asn Leu Leu Ser Phe Ala Tyr Asp Leu Glu Ala 
                645                 650                 655


Lys Ala Asn Ser Leu Pro Pro Gly Asn Leu Arg Asn Ser Leu Lys Arg 
            660                 665                 670


Asp Ala Gln Thr Ile Lys Thr Ile His Gln Gln Arg Val Leu Pro Ile 
        675                 680                 685


Glu Gln Ser Leu Ser Thr Leu Tyr Gln Ser Val Lys Ile Leu Gln Arg 
    690                 695                 700


Thr Gly Asn Gly Leu Leu Glu Arg Val Thr Arg Ile Leu Ala Ser Leu 
705                 710                 715                 720


Asp Phe Ala Gln Asn Phe Ile Thr Asn Asn Thr Ser Ser Val Ile Ile 
                725                 730                 735


Glu Glu Thr Lys Lys Tyr Gly Arg Thr Ile Ile Gly Tyr Phe Glu His 
            740                 745                 750


Tyr Leu Gln Trp Ile Glu Phe Ser Ile Ser Glu Lys Val Ala Ser Cys 
        755                 760                 765


Lys Pro Val Ala Thr Ala Leu Asp Thr Ala Val Asp Val Phe Leu Cys 
    770                 775                 780


Ser Tyr Ile Ile Asp Pro Leu Asn Leu Phe Trp Phe Gly Ile Gly Lys 
785                 790                 795                 800


Ala Thr Val Phe Leu Leu Pro Ala Leu Ile Phe Ala Val Lys Leu Ala 
                805                 810                 815


Lys Tyr Tyr Arg Arg Met Asp Ser Glu Asp Val Tyr Asp Asp Val Glu 
            820                 825                 830


Thr Ile Pro Met Lys Asn Met Glu Asn Gly Asn Asn Gly Tyr His Lys 
        835                 840                 845


Asp His Val Tyr Gly Ile His Asn Pro Val Met Thr Ser Pro Ser Gln 
    850                 855                 860


His 
865


<210>  2404
<211>  4659
<212>  DNA
<213>  Homo sapiens

<400>  2404
tgggagcgaa tatggcttta tgctgttttt caaccgcttc agccactagc attggtactg     60

ctgcacacta aggatccaaa tgattgtttt tttgtttttt gttttgtttt gttttgtttt    120

gttttgtttt aaattgcatt gggattaggc aacagaaggg tctaatgcgg ccgggatgag    180

acaggagagt ttttaggagg gtagctgcat tctaagtaag ggactctgcg gggggaaaag    240

aggcgcaagc gttgcaagaa gggagtgcag ggggttgagc aggcacctct acaggaaatg    300

gatgctgtcc aggtgctggt gggcgcccca gggctacgtg gcgaagcagc tcagccggtc    360

caatcagagt gcgtccaggg ctcgggtttc gcgatcttta agtgactgag gcagatcccc    420

acgcggcacc tggccatgct ctcagctctc ccgccgcggt gagtatgttt aaggaatcct    480

ttccattacg gcggccccat acctaggtcc ccgtccggga cagaggaagc cgcaacgggt    540

ccccccgggc acccgggcct ttctcctgcc tcccgccacg tccgagggtc cggccgcagc    600

gccgcctgag cccctccgcg gccggcagtg ggaggcgggc tctccgaaag ccgtcgcggt    660

ggtcccagaa gccgggtcat aaggatggtg ccttgagtga atgaccccct tggagaacat    720

tcttccgcat ccctcgcctc aagccagcct cagacagaaa actgaagatt cagcagatcc    780

agtgcttcct gctcctcttc tgcccaggaa cacgcttgcc ttccccaagg cttccagaag    840

ctctgaggca ggaggcacca agttctacct catgtttgga ggatcttgct agctatggcc    900

ctcgtactcg gctccctgtt gctgctgggg ctgtgcggga actccttttc aggagggcag    960

ccttcatcca cagatgctcc taaggcttgg aattatgaat tgcctgcaac aaattatgag   1020

acccaagact cccataaagc tggacccatt ggcattctct ttgaactagt gcatatcttt   1080

ctctatgtgg tacagccgcg tgatttccca gaagatactt tgagaaaatt cttacagaag   1140

gcatatgaat ccaaaattga ttatgacaag ccagaaactg taatcttagg tctaaagatt   1200

gtctactatg aagcagggat tattctatgc tgtgtcctgg ggctgctgtt tattattctg   1260

atgcctctgg tggggtattt cttttgtatg tgtcgttgct gtaacaaatg tggtggagaa   1320

atgcaccagc gacagaagga aaatgggccc ttcctgagga aatgctttgc aatctccctg   1380

ttggtgattt gtataataat aagcattggc atcttctatg gttttgtggc aaatcaccag   1440

gtaagaaccc ggatcaaaag gagtcggaaa ctggcagata gcaatttcaa ggacttgcga   1500

actctcttga atgaaactcc agagcaaatc aaatatatat tggcccagta caacactacc   1560

aaggacaagg cgttcacaga tctgaacagt atcaattcag tgctaggagg cggaattctt   1620

gaccgactga gacccaacat catccctgtt cttgatgaga ttaagtccat ggcaacagcg   1680

atcaaggaga ccaaagaggc gttggagaac atgaacagca ccttgaagag cttgcaccaa   1740

caaagtacac agcttagcag cagtctgacc agcgtgaaaa ctagcctgcg gtcatctctc   1800

aatgaccctc tgtgcttggt gcatccatca agtgaaacct gcaacagcat cagattgtct   1860

ctaagccagc tgaatagcaa ccctgaactg aggcagcttc cacccgtgga tgcagaactt   1920

gacaacgtta ataacgttct taggacagat ttggatggcc tggtccaaca gggctatcaa   1980

tcccttaatg atatacctga cagagtacaa cgccaaacca cgactgtcgt agcaggtatc   2040

aaaagggtct tgaattccat tggttcagat atcgacaatg taactcagcg tcttcctatt   2100

caggatatac tctcagcatt ctctgtttat gttaataaca ctgaaagtta catccacaga   2160

aatttaccta cattggaaga gtatgattca tactggtggc tgggtggcct ggtcatctgc   2220

tctctgctga ccctcatcgt gattttttac tacctgggct tactgtgtgg cgtgtgcggc   2280

tatgacaggc atgccacccc gaccacccga ggctgtgtct ccaacaccgg aggcgtcttc   2340

ctcatggttg gagttggatt aagtttcctc ttttgctgga tattgatgat cattgtggtt   2400

cttacctttg tctttggtgc aaatgtggaa aaactgatct gtgaacctta cacgagcaag   2460

gaattattcc gggttttgga tacaccctac ttactaaatg aagactggga atactatctc   2520

tctgggaagc tatttaataa atcaaaaatg aagctcactt ttgaacaagt ttacagtgac   2580

tgcaaaaaaa atagaggcac ttacggcact cttcacctgc agaacagctt caatatcagt   2640

gaacatctca acattaatga gcatactgga agcataagca gtgaattgga aagtctgaag   2700

gtaaatctta atatctttct gttgggtgca gcaggaagaa aaaaccttca ggattttgct   2760

gcttgtggaa tagacagaat gaattatgac agctacttgg ctcagactgg taaatccccc   2820

gcaggagtga atcttttatc atttgcatat gatctagaag caaaagcaaa cagtttgccc   2880

ccaggaaatt tgaggaactc cctgaaaaga gatgcacaaa ctattaaaac aattcaccag   2940

caacgagtcc ttcctataga acaatcactg agcactctat accaaagcgt caagatactt   3000

caacgcacag ggaatggatt gttggagaga gtaactagga ttctagcttc tctggatttt   3060

gctcagaact tcatcacaaa caatacttcc tctgttatta ttgaggaaac taagaagtat   3120

gggagaacaa taataggata ttttgaacat tatctgcagt ggatcgagtt ctctatcagt   3180

gagaaagtgg catcgtgcaa acctgtggcc accgctctag atactgctgt tgatgtcttt   3240

ctgtgtagct acattatcga ccccttgaat ttgttttggt ttggcatagg aaaagctact   3300

gtatttttac ttccggctct aatttttgcg gtaaaactgg ctaagtacta tcgtcgaatg   3360

gattcggagg acgtgtacga tgatgttgaa actataccca tgaaaaatat ggaaaatggt   3420

aataatggtt atcataaaga tcatgtatat ggtattcaca atcctgttat gacaagccca   3480

tcacaacatt gatagctgat gttgaaactg cttgagcatc aggatactca aagtggaaag   3540

gatcacagat ttttggtagt ttctgggtct acaaggactt tccaaatcca ggagcaacgc   3600

cagtggcaac gtagtgactc aggcgggcac caaggcaacg gcaccattgg tctctgggta   3660

gtgctttaag aatgaacaca atcacgttat agtccatggt ccatcactat tcaaggatga   3720

ctccctccct tcctgtctat ttttgttttt tactttttta cactgagttt ctatttagac   3780

actacaacat atggggtgtt tgttcccatt ggatgcattt ctatcaaaac tctatcaaat   3840

gtgatggcta gattctaaca tattgccatg tgtggagtgt gctgaacaca caccagttta   3900

caggaaagat gcattttgtg tacagtaaac ggtgtatata ccttttgtta ccacagagtt   3960

ttttaaacaa atgagtatta taggactttc ttctaaatga gctaaataag tcaccattga   4020

cttcttggtg ctgttgaaaa taatccattt tcactaaaag tgtgtgaaac ctacagcata   4080

ttcttcacgc agagattttc atctattata ctttatcaaa gattggccat gttccacttg   4140

gaaatggcat gcaaaagcaa tcatagagaa acctgcgtaa ctccatctga caaattcaaa   4200

agagagagag agatcttgag agagaaatgc tgttcgttca aaagtggagt tgttttaaca   4260

gatgccaatt acggtgtaca gtttaacaga gttttctgtt gcattacgat aaacattaat   4320

tggagtgcag ctaacatgag tatcatcaga ctagtatcaa gtgttctaaa atgaaatatg   4380

agaagatcct gtcacaattc ttagatctgg tgtccagcat ggatgaaacc tttgagtttg   4440

gtccctaaat ttgcatgaaa gcacaaggta aatattcatt tgcttcagga gtttcatgtt   4500

ggatctgtca ttatcaaaag tgatcagcaa tgaagaactg gtcggacaaa atttaacgtt   4560

gatgtaatga aattccagat gtaggcattc cccccaggtc ttttcatgtg cagattgcag   4620

ttctgattca tttgaataaa aaggaacttg gaaaacatg                          4659


<210>  2405
<211>  865
<212>  PRT
<213>  Homo sapiens

<400>  2405

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Pro Glu Thr Val 
                85                  90                  95


Ile Leu Gly Leu Lys Ile Val Tyr Tyr Glu Ala Gly Ile Ile Leu Cys 
            100                 105                 110


Cys Val Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly Tyr 
        115                 120                 125


Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His 
    130                 135                 140


Gln Arg Gln Lys Glu Asn Gly Pro Phe Leu Arg Lys Cys Phe Ala Ile 
145                 150                 155                 160


Ser Leu Leu Val Ile Cys Ile Ile Ile Ser Ile Gly Ile Phe Tyr Gly 
                165                 170                 175


Phe Val Ala Asn His Gln Val Arg Thr Arg Ile Lys Arg Ser Arg Lys 
            180                 185                 190


Leu Ala Asp Ser Asn Phe Lys Asp Leu Arg Thr Leu Leu Asn Glu Thr 
        195                 200                 205


Pro Glu Gln Ile Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp 
    210                 215                 220


Lys Ala Phe Thr Asp Leu Asn Ser Ile Asn Ser Val Leu Gly Gly Gly 
225                 230                 235                 240


Ile Leu Asp Arg Leu Arg Pro Asn Ile Ile Pro Val Leu Asp Glu Ile 
                245                 250                 255


Lys Ser Met Ala Thr Ala Ile Lys Glu Thr Lys Glu Ala Leu Glu Asn 
            260                 265                 270


Met Asn Ser Thr Leu Lys Ser Leu His Gln Gln Ser Thr Gln Leu Ser 
        275                 280                 285


Ser Ser Leu Thr Ser Val Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp 
    290                 295                 300


Pro Leu Cys Leu Val His Pro Ser Ser Glu Thr Cys Asn Ser Ile Arg 
305                 310                 315                 320


Leu Ser Leu Ser Gln Leu Asn Ser Asn Pro Glu Leu Arg Gln Leu Pro 
                325                 330                 335


Pro Val Asp Ala Glu Leu Asp Asn Val Asn Asn Val Leu Arg Thr Asp 
            340                 345                 350


Leu Asp Gly Leu Val Gln Gln Gly Tyr Gln Ser Leu Asn Asp Ile Pro 
        355                 360                 365


Asp Arg Val Gln Arg Gln Thr Thr Thr Val Val Ala Gly Ile Lys Arg 
    370                 375                 380


Val Leu Asn Ser Ile Gly Ser Asp Ile Asp Asn Val Thr Gln Arg Leu 
385                 390                 395                 400


Pro Ile Gln Asp Ile Leu Ser Ala Phe Ser Val Tyr Val Asn Asn Thr 
                405                 410                 415


Glu Ser Tyr Ile His Arg Asn Leu Pro Thr Leu Glu Glu Tyr Asp Ser 
            420                 425                 430


Tyr Trp Trp Leu Gly Gly Leu Val Ile Cys Ser Leu Leu Thr Leu Ile 
        435                 440                 445


Val Ile Phe Tyr Tyr Leu Gly Leu Leu Cys Gly Val Cys Gly Tyr Asp 
    450                 455                 460


Arg His Ala Thr Pro Thr Thr Arg Gly Cys Val Ser Asn Thr Gly Gly 
465                 470                 475                 480


Val Phe Leu Met Val Gly Val Gly Leu Ser Phe Leu Phe Cys Trp Ile 
                485                 490                 495


Leu Met Ile Ile Val Val Leu Thr Phe Val Phe Gly Ala Asn Val Glu 
            500                 505                 510


Lys Leu Ile Cys Glu Pro Tyr Thr Ser Lys Glu Leu Phe Arg Val Leu 
        515                 520                 525


Asp Thr Pro Tyr Leu Leu Asn Glu Asp Trp Glu Tyr Tyr Leu Ser Gly 
    530                 535                 540


Lys Leu Phe Asn Lys Ser Lys Met Lys Leu Thr Phe Glu Gln Val Tyr 
545                 550                 555                 560


Ser Asp Cys Lys Lys Asn Arg Gly Thr Tyr Gly Thr Leu His Leu Gln 
                565                 570                 575


Asn Ser Phe Asn Ile Ser Glu His Leu Asn Ile Asn Glu His Thr Gly 
            580                 585                 590


Ser Ile Ser Ser Glu Leu Glu Ser Leu Lys Val Asn Leu Asn Ile Phe 
        595                 600                 605


Leu Leu Gly Ala Ala Gly Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys 
    610                 615                 620


Gly Ile Asp Arg Met Asn Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys 
625                 630                 635                 640


Ser Pro Ala Gly Val Asn Leu Leu Ser Phe Ala Tyr Asp Leu Glu Ala 
                645                 650                 655


Lys Ala Asn Ser Leu Pro Pro Gly Asn Leu Arg Asn Ser Leu Lys Arg 
            660                 665                 670


Asp Ala Gln Thr Ile Lys Thr Ile His Gln Gln Arg Val Leu Pro Ile 
        675                 680                 685


Glu Gln Ser Leu Ser Thr Leu Tyr Gln Ser Val Lys Ile Leu Gln Arg 
    690                 695                 700


Thr Gly Asn Gly Leu Leu Glu Arg Val Thr Arg Ile Leu Ala Ser Leu 
705                 710                 715                 720


Asp Phe Ala Gln Asn Phe Ile Thr Asn Asn Thr Ser Ser Val Ile Ile 
                725                 730                 735


Glu Glu Thr Lys Lys Tyr Gly Arg Thr Ile Ile Gly Tyr Phe Glu His 
            740                 745                 750


Tyr Leu Gln Trp Ile Glu Phe Ser Ile Ser Glu Lys Val Ala Ser Cys 
        755                 760                 765


Lys Pro Val Ala Thr Ala Leu Asp Thr Ala Val Asp Val Phe Leu Cys 
    770                 775                 780


Ser Tyr Ile Ile Asp Pro Leu Asn Leu Phe Trp Phe Gly Ile Gly Lys 
785                 790                 795                 800


Ala Thr Val Phe Leu Leu Pro Ala Leu Ile Phe Ala Val Lys Leu Ala 
                805                 810                 815


Lys Tyr Tyr Arg Arg Met Asp Ser Glu Asp Val Tyr Asp Asp Val Glu 
            820                 825                 830


Thr Ile Pro Met Lys Asn Met Glu Asn Gly Asn Asn Gly Tyr His Lys 
        835                 840                 845


Asp His Val Tyr Gly Ile His Asn Pro Val Met Thr Ser Pro Ser Gln 
    850                 855                 860


His 
865


<210>  2406
<211>  4721
<212>  DNA
<213>  Homo sapiens

<400>  2406
tgggagcgaa tatggcttta tgctgttttt caaccgcttc agccactagc attggtactg     60

ctgcacacta aggatccaaa tgattgtttt tttgtttttt gttttgtttt gttttgtttt    120

gttttgtttt aaattgcatt gggattaggc aacagaaggg tctaatgcgg ccgggatgag    180

acaggagagt ttttaggagg gtagctgcat tctaagtaag ggactctgcg gggggaaaag    240

aggcgcaagc gttgcaagaa gggagtgcag ggggttgagc aggcacctct acaggaaatg    300

gatgctgtcc aggtgctggt gggcgcccca gggctacgtg gcgaagcagc tcagccggtc    360

caatcagagt gcgtccaggg ctcgggtttc gcgatcttta agtgactgag gcagatcccc    420

acgcggcacc tggccatgct ctcagctctc ccgccgcggt gagtatgttt aaggaatcct    480

ttccattacg gcggccccat acctaggtcc ccgtccggga cagaggaagc cgcaacgggt    540

ccccccgggc acccgggcct ttctcctgcc tcccgccacg tccgagggtc cggccgcagc    600

gccgcctgag cccctccgcg gccggcagtg ggaggcgggc tctccgaaag ccgtcgcggt    660

ggtcccagaa gccgggtcat aaataattca cgagccaggg tctggcgagc taagggaagg    720

gcggcggcag cggtgactag ggcgggagca ggagcgggag ccgggtgcac gggatggtgc    780

cttgagtgaa tgaccccctt ggagaacatt cttccgcatc cctcgcctca agccagcctc    840

agacagaaaa ctgaagattc agcagatcca gtgcttcctg ctcctcttct gcccaggaac    900

acgcttgcct tccccaaggc ttccagaagc tctgaggcag gaggcaccaa gttctacctc    960

atgtttggag gatcttgcta gctatggccc tcgtactcgg ctccctgttg ctgctggggc   1020

tgtgcgggaa ctccttttca ggagggcagc cttcatccac agatgctcct aaggcttgga   1080

attatgaatt gcctgcaaca aattatgaga cccaagactc ccataaagct ggacccattg   1140

gcattctctt tgaactagtg catatctttc tctatgtggt acagccgcgt gatttcccag   1200

aagatacttt gagaaaattc ttacagaagg catatgaatc caaaattgat tatgacaaga   1260

ttgtctacta tgaagcaggg attattctat gctgtgtcct ggggctgctg tttattattc   1320

tgatgcctct ggtggggtat ttcttttgta tgtgtcgttg ctgtaacaaa tgtggtggag   1380

aaatgcacca gcgacagaag gaaaatgggc ccttcctgag gaaatgcttt gcaatctccc   1440

tgttggtgat ttgtataata ataagcattg gcatcttcta tggttttgtg gcaaatcacc   1500

aggtaagaac ccggatcaaa aggagtcgga aactggcaga tagcaatttc aaggacttgc   1560

gaactctctt gaatgaaact ccagagcaaa tcaaatatat attggcccag tacaacacta   1620

ccaaggacaa ggcgttcaca gatctgaaca gtatcaattc agtgctagga ggcggaattc   1680

ttgaccgact gagacccaac atcatccctg ttcttgatga gattaagtcc atggcaacag   1740

cgatcaagga gaccaaagag gcgttggaga acatgaacag caccttgaag agcttgcacc   1800

aacaaagtac acagcttagc agcagtctga ccagcgtgaa aactagcctg cggtcatctc   1860

tcaatgaccc tctgtgcttg gtgcatccat caagtgaaac ctgcaacagc atcagattgt   1920

ctctaagcca gctgaatagc aaccctgaac tgaggcagct tccacccgtg gatgcagaac   1980

ttgacaacgt taataacgtt cttaggacag atttggatgg cctggtccaa cagggctatc   2040

aatcccttaa tgatatacct gacagagtac aacgccaaac cacgactgtc gtagcaggta   2100

tcaaaagggt cttgaattcc attggttcag atatcgacaa tgtaactcag cgtcttccta   2160

ttcaggatat actctcagca ttctctgttt atgttaataa cactgaaagt tacatccaca   2220

gaaatttacc tacattggaa gagtatgatt catactggtg gctgggtggc ctggtcatct   2280

gctctctgct gaccctcatc gtgatttttt actacctggg cttactgtgt ggcgtgtgcg   2340

gctatgacag gcatgccacc ccgaccaccc gaggctgtgt ctccaacacc ggaggcgtct   2400

tcctcatggt tggagttgga ttaagtttcc tcttttgctg gatattgatg atcattgtgg   2460

ttcttacctt tgtctttggt gcaaatgtgg aaaaactgat ctgtgaacct tacacgagca   2520

aggaattatt ccgggttttg gatacaccct acttactaaa tgaagactgg gaatactatc   2580

tctctgggaa gctatttaat aaatcaaaaa tgaagctcac ttttgaacaa gtttacagtg   2640

actgcaaaaa aaatagaggc acttacggca ctcttcacct gcagaacagc ttcaatatca   2700

gtgaacatct caacattaat gagcatactg gaagcataag cagtgaattg gaaagtctga   2760

aggtaaatct taatatcttt ctgttgggtg cagcaggaag aaaaaacctt caggattttg   2820

ctgcttgtgg aatagacaga atgaattatg acagctactt ggctcagact ggtaaatccc   2880

ccgcaggagt gaatctttta tcatttgcat atgatctaga agcaaaagca aacagtttgc   2940

ccccaggaaa tttgaggaac tccctgaaaa gagatgcaca aactattaaa acaattcacc   3000

agcaacgagt ccttcctata gaacaatcac tgagcactct ataccaaagc gtcaagatac   3060

ttcaacgcac agggaatgga ttgttggaga gagtaactag gattctagct tctctggatt   3120

ttgctcagaa cttcatcaca aacaatactt cctctgttat tattgaggaa actaagaagt   3180

atgggagaac aataatagga tattttgaac attatctgca gtggatcgag ttctctatca   3240

gtgagaaagt ggcatcgtgc aaacctgtgg ccaccgctct agatactgct gttgatgtct   3300

ttctgtgtag ctacattatc gaccccttga atttgttttg gtttggcata ggaaaagcta   3360

ctgtattttt acttccggct ctaatttttg cggtaaaact ggctaagtac tatcgtcgaa   3420

tggattcgga ggacgtgtac gatgatgttg aaactatacc catgaaaaat atggaaaatg   3480

gtaataatgg ttatcataaa gatcatgtat atggtattca caatcctgtt atgacaagcc   3540

catcacaaca ttgatagctg atgttgaaac tgcttgagca tcaggatact caaagtggaa   3600

aggatcacag atttttggta gtttctgggt ctacaaggac tttccaaatc caggagcaac   3660

gccagtggca acgtagtgac tcaggcgggc accaaggcaa cggcaccatt ggtctctggg   3720

tagtgcttta agaatgaaca caatcacgtt atagtccatg gtccatcact attcaaggat   3780

gactccctcc cttcctgtct atttttgttt tttacttttt tacactgagt ttctatttag   3840

acactacaac atatggggtg tttgttccca ttggatgcat ttctatcaaa actctatcaa   3900

atgtgatggc tagattctaa catattgcca tgtgtggagt gtgctgaaca cacaccagtt   3960

tacaggaaag atgcattttg tgtacagtaa acggtgtata taccttttgt taccacagag   4020

ttttttaaac aaatgagtat tataggactt tcttctaaat gagctaaata agtcaccatt   4080

gacttcttgg tgctgttgaa aataatccat tttcactaaa agtgtgtgaa acctacagca   4140

tattcttcac gcagagattt tcatctatta tactttatca aagattggcc atgttccact   4200

tggaaatggc atgcaaaagc aatcatagag aaacctgcgt aactccatct gacaaattca   4260

aaagagagag agagatcttg agagagaaat gctgttcgtt caaaagtgga gttgttttaa   4320

cagatgccaa ttacggtgta cagtttaaca gagttttctg ttgcattacg ataaacatta   4380

attggagtgc agctaacatg agtatcatca gactagtatc aagtgttcta aaatgaaata   4440

tgagaagatc ctgtcacaat tcttagatct ggtgtccagc atggatgaaa cctttgagtt   4500

tggtccctaa atttgcatga aagcacaagg taaatattca tttgcttcag gagtttcatg   4560

ttggatctgt cattatcaaa agtgatcagc aatgaagaac tggtcggaca aaatttaacg   4620

ttgatgtaat gaaattccag atgtaggcat tccccccagg tcttttcatg tgcagattgc   4680

agttctgatt catttgaata aaaaggaact tggaaaacat g                       4721


<210>  2407
<211>  856
<212>  PRT
<213>  Homo sapiens

<400>  2407

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Ile Val Tyr Tyr 
                85                  90                  95


Glu Ala Gly Ile Ile Leu Cys Cys Val Leu Gly Leu Leu Phe Ile Ile 
            100                 105                 110


Leu Met Pro Leu Val Gly Tyr Phe Phe Cys Met Cys Arg Cys Cys Asn 
        115                 120                 125


Lys Cys Gly Gly Glu Met His Gln Arg Gln Lys Glu Asn Gly Pro Phe 
    130                 135                 140


Leu Arg Lys Cys Phe Ala Ile Ser Leu Leu Val Ile Cys Ile Ile Ile 
145                 150                 155                 160


Ser Ile Gly Ile Phe Tyr Gly Phe Val Ala Asn His Gln Val Arg Thr 
                165                 170                 175


Arg Ile Lys Arg Ser Arg Lys Leu Ala Asp Ser Asn Phe Lys Asp Leu 
            180                 185                 190


Arg Thr Leu Leu Asn Glu Thr Pro Glu Gln Ile Lys Tyr Ile Leu Ala 
        195                 200                 205


Gln Tyr Asn Thr Thr Lys Asp Lys Ala Phe Thr Asp Leu Asn Ser Ile 
    210                 215                 220


Asn Ser Val Leu Gly Gly Gly Ile Leu Asp Arg Leu Arg Pro Asn Ile 
225                 230                 235                 240


Ile Pro Val Leu Asp Glu Ile Lys Ser Met Ala Thr Ala Ile Lys Glu 
                245                 250                 255


Thr Lys Glu Ala Leu Glu Asn Met Asn Ser Thr Leu Lys Ser Leu His 
            260                 265                 270


Gln Gln Ser Thr Gln Leu Ser Ser Ser Leu Thr Ser Val Lys Thr Ser 
        275                 280                 285


Leu Arg Ser Ser Leu Asn Asp Pro Leu Cys Leu Val His Pro Ser Ser 
    290                 295                 300


Glu Thr Cys Asn Ser Ile Arg Leu Ser Leu Ser Gln Leu Asn Ser Asn 
305                 310                 315                 320


Pro Glu Leu Arg Gln Leu Pro Pro Val Asp Ala Glu Leu Asp Asn Val 
                325                 330                 335


Asn Asn Val Leu Arg Thr Asp Leu Asp Gly Leu Val Gln Gln Gly Tyr 
            340                 345                 350


Gln Ser Leu Asn Asp Ile Pro Asp Arg Val Gln Arg Gln Thr Thr Thr 
        355                 360                 365


Val Val Ala Gly Ile Lys Arg Val Leu Asn Ser Ile Gly Ser Asp Ile 
    370                 375                 380


Asp Asn Val Thr Gln Arg Leu Pro Ile Gln Asp Ile Leu Ser Ala Phe 
385                 390                 395                 400


Ser Val Tyr Val Asn Asn Thr Glu Ser Tyr Ile His Arg Asn Leu Pro 
                405                 410                 415


Thr Leu Glu Glu Tyr Asp Ser Tyr Trp Trp Leu Gly Gly Leu Val Ile 
            420                 425                 430


Cys Ser Leu Leu Thr Leu Ile Val Ile Phe Tyr Tyr Leu Gly Leu Leu 
        435                 440                 445


Cys Gly Val Cys Gly Tyr Asp Arg His Ala Thr Pro Thr Thr Arg Gly 
    450                 455                 460


Cys Val Ser Asn Thr Gly Gly Val Phe Leu Met Val Gly Val Gly Leu 
465                 470                 475                 480


Ser Phe Leu Phe Cys Trp Ile Leu Met Ile Ile Val Val Leu Thr Phe 
                485                 490                 495


Val Phe Gly Ala Asn Val Glu Lys Leu Ile Cys Glu Pro Tyr Thr Ser 
            500                 505                 510


Lys Glu Leu Phe Arg Val Leu Asp Thr Pro Tyr Leu Leu Asn Glu Asp 
        515                 520                 525


Trp Glu Tyr Tyr Leu Ser Gly Lys Leu Phe Asn Lys Ser Lys Met Lys 
    530                 535                 540


Leu Thr Phe Glu Gln Val Tyr Ser Asp Cys Lys Lys Asn Arg Gly Thr 
545                 550                 555                 560


Tyr Gly Thr Leu His Leu Gln Asn Ser Phe Asn Ile Ser Glu His Leu 
                565                 570                 575


Asn Ile Asn Glu His Thr Gly Ser Ile Ser Ser Glu Leu Glu Ser Leu 
            580                 585                 590


Lys Val Asn Leu Asn Ile Phe Leu Leu Gly Ala Ala Gly Arg Lys Asn 
        595                 600                 605


Leu Gln Asp Phe Ala Ala Cys Gly Ile Asp Arg Met Asn Tyr Asp Ser 
    610                 615                 620


Tyr Leu Ala Gln Thr Gly Lys Ser Pro Ala Gly Val Asn Leu Leu Ser 
625                 630                 635                 640


Phe Ala Tyr Asp Leu Glu Ala Lys Ala Asn Ser Leu Pro Pro Gly Asn 
                645                 650                 655


Leu Arg Asn Ser Leu Lys Arg Asp Ala Gln Thr Ile Lys Thr Ile His 
            660                 665                 670


Gln Gln Arg Val Leu Pro Ile Glu Gln Ser Leu Ser Thr Leu Tyr Gln 
        675                 680                 685


Ser Val Lys Ile Leu Gln Arg Thr Gly Asn Gly Leu Leu Glu Arg Val 
    690                 695                 700


Thr Arg Ile Leu Ala Ser Leu Asp Phe Ala Gln Asn Phe Ile Thr Asn 
705                 710                 715                 720


Asn Thr Ser Ser Val Ile Ile Glu Glu Thr Lys Lys Tyr Gly Arg Thr 
                725                 730                 735


Ile Ile Gly Tyr Phe Glu His Tyr Leu Gln Trp Ile Glu Phe Ser Ile 
            740                 745                 750


Ser Glu Lys Val Ala Ser Cys Lys Pro Val Ala Thr Ala Leu Asp Thr 
        755                 760                 765


Ala Val Asp Val Phe Leu Cys Ser Tyr Ile Ile Asp Pro Leu Asn Leu 
    770                 775                 780


Phe Trp Phe Gly Ile Gly Lys Ala Thr Val Phe Leu Leu Pro Ala Leu 
785                 790                 795                 800


Ile Phe Ala Val Lys Leu Ala Lys Tyr Tyr Arg Arg Met Asp Ser Glu 
                805                 810                 815


Asp Val Tyr Asp Asp Val Glu Thr Ile Pro Met Lys Asn Met Glu Asn 
            820                 825                 830


Gly Asn Asn Gly Tyr His Lys Asp His Val Tyr Gly Ile His Asn Pro 
        835                 840                 845


Val Met Thr Ser Pro Ser Gln His 
    850                 855


<210>  2408
<211>  4419
<212>  DNA
<213>  Homo sapiens

<400>  2408
gtgggctcct ttctcgtgga tctggacccc aggagttccc aggcatagag aggaggggtg     60

ccagtggagt gtaagcacca tgacaacagg aactgtgtct tgaccactgt tgacttccaa    120

gcacctcaaa taggacctgt cacatagaag tttcaatcaa tatttgttga gtgaatgaag    180

acaacaggtg tcaacttagc ttctactaca gttctaagac ttttgcgtca agaagtgggg    240

acactccaga tgcaatgtgc caacgacctc acagacacag gttgtggata gcagcagaca    300

tggaggtgga ggctgggcgg ccagtgatgc tgtgagtcag ttctgcaggc tgtacgggaa    360

gcacggcacc agtatctgct tctggtgagg actcaggagc ttaaaatcat ggtggaagca    420

gggagagcaa gcatgtcaca agggatggtg ccttgagtga atgaccccct tggagaacat    480

tcttccgcat ccctcgcctc aagccagcct cagacagaaa actgaagatt cagcagatcc    540

agtgcttcct gctcctcttc tgcccaggaa cacgcttgcc ttccccaagg cttccagaag    600

ctctgaggca ggaggcacca agttctacct catgtttgga ggatcttgct agctatggcc    660

ctcgtactcg gctccctgtt gctgctgggg ctgtgcggga actccttttc aggagggcag    720

ccttcatcca cagatgctcc taaggcttgg aattatgaat tgcctgcaac aaattatgag    780

acccaagact cccataaagc tggacccatt ggcattctct ttgaactagt gcatatcttt    840

ctctatgtgg tacagccgcg tgatttccca gaagatactt tgagaaaatt cttacagaag    900

gcatatgaat ccaaaattga ttatgacaag ccagaaactg taatcttagg tctaaagatt    960

gtctactatg aagcagggat tattctatgc tgtgtcctgg ggctgctgtt tattattctg   1020

atgcctctgg tggggtattt cttttgtatg tgtcgttgct gtaacaaatg tggtggagaa   1080

atgcaccagc gacagaagga aaatgggccc ttcctgagga aatgctttgc aatctccctg   1140

ttggtgattt gtataataat aagcattggc atcttctatg gttttgtggc aaatcaccag   1200

gtaagaaccc ggatcaaaag gagtcggaaa ctggcagata gcaatttcaa ggacttgcga   1260

actctcttga atgaaactcc agagcaaatc aaatatatat tggcccagta caacactacc   1320

aaggacaagg cgttcacaga tctgaacagt atcaattcag tgctaggagg cggaattctt   1380

gaccgactga gacccaacat catccctgtt cttgatgaga ttaagtccat ggcaacagcg   1440

atcaaggaga ccaaagaggc gttggagaac atgaacagca ccttgaagag cttgcaccaa   1500

caaagtacac agcttagcag cagtctgacc agcgtgaaaa ctagcctgcg gtcatctctc   1560

aatgaccctc tgtgcttggt gcatccatca agtgaaacct gcaacagcat cagattgtct   1620

ctaagccagc tgaatagcaa ccctgaactg aggcagcttc cacccgtgga tgcagaactt   1680

gacaacgtta ataacgttct taggacagat ttggatggcc tggtccaaca gggctatcaa   1740

tcccttaatg atatacctga cagagtacaa cgccaaacca cgactgtcgt agcaggtatc   1800

aaaagggtct tgaattccat tggttcagat atcgacaatg taactcagcg tcttcctatt   1860

caggatatac tctcagcatt ctctgtttat gttaataaca ctgaaagtta catccacaga   1920

aatttaccta cattggaaga gtatgattca tactggtggc tgggtggcct ggtcatctgc   1980

tctctgctga ccctcatcgt gattttttac tacctgggct tactgtgtgg cgtgtgcggc   2040

tatgacaggc atgccacccc gaccacccga ggctgtgtct ccaacaccgg aggcgtcttc   2100

ctcatggttg gagttggatt aagtttcctc ttttgctgga tattgatgat cattgtggtt   2160

cttacctttg tctttggtgc aaatgtggaa aaactgatct gtgaacctta cacgagcaag   2220

gaattattcc gggttttgga tacaccctac ttactaaatg aagactggga atactatctc   2280

tctgggaagc tatttaataa atcaaaaatg aagctcactt ttgaacaagt ttacagtgac   2340

tgcaaaaaaa atagaggcac ttacggcact cttcacctgc agaacagctt caatatcagt   2400

gaacatctca acattaatga gcatactgga agcataagca gtgaattgga aagtctgaag   2460

gtaaatctta atatctttct gttgggtgca gcaggaagaa aaaaccttca ggattttgct   2520

gcttgtggaa tagacagaat gaattatgac agctacttgg ctcagactgg taaatccccc   2580

gcaggagtga atcttttatc atttgcatat gatctagaag caaaagcaaa cagtttgccc   2640

ccaggaaatt tgaggaactc cctgaaaaga gatgcacaaa ctattaaaac aattcaccag   2700

caacgagtcc ttcctataga acaatcactg agcactctat accaaagcgt caagatactt   2760

caacgcacag ggaatggatt gttggagaga gtaactagga ttctagcttc tctggatttt   2820

gctcagaact tcatcacaaa caatacttcc tctgttatta ttgaggaaac taagaagtat   2880

gggagaacaa taataggata ttttgaacat tatctgcagt ggatcgagtt ctctatcagt   2940

gagaaagtgg catcgtgcaa acctgtggcc accgctctag atactgctgt tgatgtcttt   3000

ctgtgtagct acattatcga ccccttgaat ttgttttggt ttggcatagg aaaagctact   3060

gtatttttac ttccggctct aatttttgcg gtaaaactgg ctaagtacta tcgtcgaatg   3120

gattcggagg acgtgtacga tgatgttgaa actataccca tgaaaaatat ggaaaatggt   3180

aataatggtt atcataaaga tcatgtatat ggtattcaca atcctgttat gacaagccca   3240

tcacaacatt gatagctgat gttgaaactg cttgagcatc aggatactca aagtggaaag   3300

gatcacagat ttttggtagt ttctgggtct acaaggactt tccaaatcca ggagcaacgc   3360

cagtggcaac gtagtgactc aggcgggcac caaggcaacg gcaccattgg tctctgggta   3420

gtgctttaag aatgaacaca atcacgttat agtccatggt ccatcactat tcaaggatga   3480

ctccctccct tcctgtctat ttttgttttt tactttttta cactgagttt ctatttagac   3540

actacaacat atggggtgtt tgttcccatt ggatgcattt ctatcaaaac tctatcaaat   3600

gtgatggcta gattctaaca tattgccatg tgtggagtgt gctgaacaca caccagttta   3660

caggaaagat gcattttgtg tacagtaaac ggtgtatata ccttttgtta ccacagagtt   3720

ttttaaacaa atgagtatta taggactttc ttctaaatga gctaaataag tcaccattga   3780

cttcttggtg ctgttgaaaa taatccattt tcactaaaag tgtgtgaaac ctacagcata   3840

ttcttcacgc agagattttc atctattata ctttatcaaa gattggccat gttccacttg   3900

gaaatggcat gcaaaagcaa tcatagagaa acctgcgtaa ctccatctga caaattcaaa   3960

agagagagag agatcttgag agagaaatgc tgttcgttca aaagtggagt tgttttaaca   4020

gatgccaatt acggtgtaca gtttaacaga gttttctgtt gcattacgat aaacattaat   4080

tggagtgcag ctaacatgag tatcatcaga ctagtatcaa gtgttctaaa atgaaatatg   4140

agaagatcct gtcacaattc ttagatctgg tgtccagcat ggatgaaacc tttgagtttg   4200

gtccctaaat ttgcatgaaa gcacaaggta aatattcatt tgcttcagga gtttcatgtt   4260

ggatctgtca ttatcaaaag tgatcagcaa tgaagaactg gtcggacaaa atttaacgtt   4320

gatgtaatga aattccagat gtaggcattc cccccaggtc ttttcatgtg cagattgcag   4380

ttctgattca tttgaataaa aaggaacttg gaaaacatg                          4419


<210>  2409
<211>  865
<212>  PRT
<213>  Homo sapiens

<400>  2409

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Pro Glu Thr Val 
                85                  90                  95


Ile Leu Gly Leu Lys Ile Val Tyr Tyr Glu Ala Gly Ile Ile Leu Cys 
            100                 105                 110


Cys Val Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly Tyr 
        115                 120                 125


Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His 
    130                 135                 140


Gln Arg Gln Lys Glu Asn Gly Pro Phe Leu Arg Lys Cys Phe Ala Ile 
145                 150                 155                 160


Ser Leu Leu Val Ile Cys Ile Ile Ile Ser Ile Gly Ile Phe Tyr Gly 
                165                 170                 175


Phe Val Ala Asn His Gln Val Arg Thr Arg Ile Lys Arg Ser Arg Lys 
            180                 185                 190


Leu Ala Asp Ser Asn Phe Lys Asp Leu Arg Thr Leu Leu Asn Glu Thr 
        195                 200                 205


Pro Glu Gln Ile Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp 
    210                 215                 220


Lys Ala Phe Thr Asp Leu Asn Ser Ile Asn Ser Val Leu Gly Gly Gly 
225                 230                 235                 240


Ile Leu Asp Arg Leu Arg Pro Asn Ile Ile Pro Val Leu Asp Glu Ile 
                245                 250                 255


Lys Ser Met Ala Thr Ala Ile Lys Glu Thr Lys Glu Ala Leu Glu Asn 
            260                 265                 270


Met Asn Ser Thr Leu Lys Ser Leu His Gln Gln Ser Thr Gln Leu Ser 
        275                 280                 285


Ser Ser Leu Thr Ser Val Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp 
    290                 295                 300


Pro Leu Cys Leu Val His Pro Ser Ser Glu Thr Cys Asn Ser Ile Arg 
305                 310                 315                 320


Leu Ser Leu Ser Gln Leu Asn Ser Asn Pro Glu Leu Arg Gln Leu Pro 
                325                 330                 335


Pro Val Asp Ala Glu Leu Asp Asn Val Asn Asn Val Leu Arg Thr Asp 
            340                 345                 350


Leu Asp Gly Leu Val Gln Gln Gly Tyr Gln Ser Leu Asn Asp Ile Pro 
        355                 360                 365


Asp Arg Val Gln Arg Gln Thr Thr Thr Val Val Ala Gly Ile Lys Arg 
    370                 375                 380


Val Leu Asn Ser Ile Gly Ser Asp Ile Asp Asn Val Thr Gln Arg Leu 
385                 390                 395                 400


Pro Ile Gln Asp Ile Leu Ser Ala Phe Ser Val Tyr Val Asn Asn Thr 
                405                 410                 415


Glu Ser Tyr Ile His Arg Asn Leu Pro Thr Leu Glu Glu Tyr Asp Ser 
            420                 425                 430


Tyr Trp Trp Leu Gly Gly Leu Val Ile Cys Ser Leu Leu Thr Leu Ile 
        435                 440                 445


Val Ile Phe Tyr Tyr Leu Gly Leu Leu Cys Gly Val Cys Gly Tyr Asp 
    450                 455                 460


Arg His Ala Thr Pro Thr Thr Arg Gly Cys Val Ser Asn Thr Gly Gly 
465                 470                 475                 480


Val Phe Leu Met Val Gly Val Gly Leu Ser Phe Leu Phe Cys Trp Ile 
                485                 490                 495


Leu Met Ile Ile Val Val Leu Thr Phe Val Phe Gly Ala Asn Val Glu 
            500                 505                 510


Lys Leu Ile Cys Glu Pro Tyr Thr Ser Lys Glu Leu Phe Arg Val Leu 
        515                 520                 525


Asp Thr Pro Tyr Leu Leu Asn Glu Asp Trp Glu Tyr Tyr Leu Ser Gly 
    530                 535                 540


Lys Leu Phe Asn Lys Ser Lys Met Lys Leu Thr Phe Glu Gln Val Tyr 
545                 550                 555                 560


Ser Asp Cys Lys Lys Asn Arg Gly Thr Tyr Gly Thr Leu His Leu Gln 
                565                 570                 575


Asn Ser Phe Asn Ile Ser Glu His Leu Asn Ile Asn Glu His Thr Gly 
            580                 585                 590


Ser Ile Ser Ser Glu Leu Glu Ser Leu Lys Val Asn Leu Asn Ile Phe 
        595                 600                 605


Leu Leu Gly Ala Ala Gly Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys 
    610                 615                 620


Gly Ile Asp Arg Met Asn Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys 
625                 630                 635                 640


Ser Pro Ala Gly Val Asn Leu Leu Ser Phe Ala Tyr Asp Leu Glu Ala 
                645                 650                 655


Lys Ala Asn Ser Leu Pro Pro Gly Asn Leu Arg Asn Ser Leu Lys Arg 
            660                 665                 670


Asp Ala Gln Thr Ile Lys Thr Ile His Gln Gln Arg Val Leu Pro Ile 
        675                 680                 685


Glu Gln Ser Leu Ser Thr Leu Tyr Gln Ser Val Lys Ile Leu Gln Arg 
    690                 695                 700


Thr Gly Asn Gly Leu Leu Glu Arg Val Thr Arg Ile Leu Ala Ser Leu 
705                 710                 715                 720


Asp Phe Ala Gln Asn Phe Ile Thr Asn Asn Thr Ser Ser Val Ile Ile 
                725                 730                 735


Glu Glu Thr Lys Lys Tyr Gly Arg Thr Ile Ile Gly Tyr Phe Glu His 
            740                 745                 750


Tyr Leu Gln Trp Ile Glu Phe Ser Ile Ser Glu Lys Val Ala Ser Cys 
        755                 760                 765


Lys Pro Val Ala Thr Ala Leu Asp Thr Ala Val Asp Val Phe Leu Cys 
    770                 775                 780


Ser Tyr Ile Ile Asp Pro Leu Asn Leu Phe Trp Phe Gly Ile Gly Lys 
785                 790                 795                 800


Ala Thr Val Phe Leu Leu Pro Ala Leu Ile Phe Ala Val Lys Leu Ala 
                805                 810                 815


Lys Tyr Tyr Arg Arg Met Asp Ser Glu Asp Val Tyr Asp Asp Val Glu 
            820                 825                 830


Thr Ile Pro Met Lys Asn Met Glu Asn Gly Asn Asn Gly Tyr His Lys 
        835                 840                 845


Asp His Val Tyr Gly Ile His Asn Pro Val Met Thr Ser Pro Ser Gln 
    850                 855                 860


His 
865


<210>  2410
<211>  4367
<212>  DNA
<213>  Homo sapiens

<400>  2410
agcagctcag tgcagtggaa aatttcatgg aagccaaaat ccctgcctct tactggatat     60

gagggccttt gaggggaaca tccaacctct ctgagcctca gtgtcctcat ccgcaaaaca    120

gataataact cctctctcac agagtgtgga ttcgtttttg agggctgctg taacaaagta    180

ccacagacca agtagcttaa acaagtgcca acgacctcac agacacaggt tgtggatagc    240

agcagacatg gaggtggagg ctgggcggcc agtgatgctg tgagtcagtt ctgcaggctg    300

tacgggaagc acggcaccag tatctgcttc tggtgaggac tcaggagctt aaaatcatgg    360

tggaagcagg gagagcaagc atgtcacaag ggatggtgcc ttgagtgaat gacccccttg    420

gagaacattc ttccgcatcc ctcgcctcaa gccagcctca gacagaaaac tgaagattca    480

gcagatccag tgcttcctgc tcctcttctg cccaggaaca cgcttgcctt ccccaaggct    540

tccagaagct ctgaggcagg aggcaccaag ttctacctca tgtttggagg atcttgctag    600

ctatggccct cgtactcggc tccctgttgc tgctggggct gtgcgggaac tccttttcag    660

gagggcagcc ttcatccaca gatgctccta aggcttggaa ttatgaattg cctgcaacaa    720

attatgagac ccaagactcc cataaagctg gacccattgg cattctcttt gaactagtgc    780

atatctttct ctatgtggta cagccgcgtg atttcccaga agatactttg agaaaattct    840

tacagaaggc atatgaatcc aaaattgatt atgacaagcc agaaactgta atcttaggtc    900

taaagattgt ctactatgaa gcagggatta ttctatgctg tgtcctgggg ctgctgttta    960

ttattctgat gcctctggtg gggtatttct tttgtatgtg tcgttgctgt aacaaatgtg   1020

gtggagaaat gcaccagcga cagaaggaaa atgggccctt cctgaggaaa tgctttgcaa   1080

tctccctgtt ggtgatttgt ataataataa gcattggcat cttctatggt tttgtggcaa   1140

atcaccaggt aagaacccgg atcaaaagga gtcggaaact ggcagatagc aatttcaagg   1200

acttgcgaac tctcttgaat gaaactccag agcaaatcaa atatatattg gcccagtaca   1260

acactaccaa ggacaaggcg ttcacagatc tgaacagtat caattcagtg ctaggaggcg   1320

gaattcttga ccgactgaga cccaacatca tccctgttct tgatgagatt aagtccatgg   1380

caacagcgat caaggagacc aaagaggcgt tggagaacat gaacagcacc ttgaagagct   1440

tgcaccaaca aagtacacag cttagcagca gtctgaccag cgtgaaaact agcctgcggt   1500

catctctcaa tgaccctctg tgcttggtgc atccatcaag tgaaacctgc aacagcatca   1560

gattgtctct aagccagctg aatagcaacc ctgaactgag gcagcttcca cccgtggatg   1620

cagaacttga caacgttaat aacgttctta ggacagattt ggatggcctg gtccaacagg   1680

gctatcaatc ccttaatgat atacctgaca gagtacaacg ccaaaccacg actgtcgtag   1740

caggtatcaa aagggtcttg aattccattg gttcagatat cgacaatgta actcagcgtc   1800

ttcctattca ggatatactc tcagcattct ctgtttatgt taataacact gaaagttaca   1860

tccacagaaa tttacctaca ttggaagagt atgattcata ctggtggctg ggtggcctgg   1920

tcatctgctc tctgctgacc ctcatcgtga ttttttacta cctgggctta ctgtgtggcg   1980

tgtgcggcta tgacaggcat gccaccccga ccacccgagg ctgtgtctcc aacaccggag   2040

gcgtcttcct catggttgga gttggattaa gtttcctctt ttgctggata ttgatgatca   2100

ttgtggttct tacctttgtc tttggtgcaa atgtggaaaa actgatctgt gaaccttaca   2160

cgagcaagga attattccgg gttttggata caccctactt actaaatgaa gactgggaat   2220

actatctctc tgggaagcta tttaataaat caaaaatgaa gctcactttt gaacaagttt   2280

acagtgactg caaaaaaaat agaggcactt acggcactct tcacctgcag aacagcttca   2340

atatcagtga acatctcaac attaatgagc atactggaag cataagcagt gaattggaaa   2400

gtctgaaggt aaatcttaat atctttctgt tgggtgcagc aggaagaaaa aaccttcagg   2460

attttgctgc ttgtggaata gacagaatga attatgacag ctacttggct cagactggta   2520

aatcccccgc aggagtgaat cttttatcat ttgcatatga tctagaagca aaagcaaaca   2580

gtttgccccc aggaaatttg aggaactccc tgaaaagaga tgcacaaact attaaaacaa   2640

ttcaccagca acgagtcctt cctatagaac aatcactgag cactctatac caaagcgtca   2700

agatacttca acgcacaggg aatggattgt tggagagagt aactaggatt ctagcttctc   2760

tggattttgc tcagaacttc atcacaaaca atacttcctc tgttattatt gaggaaacta   2820

agaagtatgg gagaacaata ataggatatt ttgaacatta tctgcagtgg atcgagttct   2880

ctatcagtga gaaagtggca tcgtgcaaac ctgtggccac cgctctagat actgctgttg   2940

atgtctttct gtgtagctac attatcgacc ccttgaattt gttttggttt ggcataggaa   3000

aagctactgt atttttactt ccggctctaa tttttgcggt aaaactggct aagtactatc   3060

gtcgaatgga ttcggaggac gtgtacgatg atgttgaaac tatacccatg aaaaatatgg   3120

aaaatggtaa taatggttat cataaagatc atgtatatgg tattcacaat cctgttatga   3180

caagcccatc acaacattga tagctgatgt tgaaactgct tgagcatcag gatactcaaa   3240

gtggaaagga tcacagattt ttggtagttt ctgggtctac aaggactttc caaatccagg   3300

agcaacgcca gtggcaacgt agtgactcag gcgggcacca aggcaacggc accattggtc   3360

tctgggtagt gctttaagaa tgaacacaat cacgttatag tccatggtcc atcactattc   3420

aaggatgact ccctcccttc ctgtctattt ttgtttttta cttttttaca ctgagtttct   3480

atttagacac tacaacatat ggggtgtttg ttcccattgg atgcatttct atcaaaactc   3540

tatcaaatgt gatggctaga ttctaacata ttgccatgtg tggagtgtgc tgaacacaca   3600

ccagtttaca ggaaagatgc attttgtgta cagtaaacgg tgtatatacc ttttgttacc   3660

acagagtttt ttaaacaaat gagtattata ggactttctt ctaaatgagc taaataagtc   3720

accattgact tcttggtgct gttgaaaata atccattttc actaaaagtg tgtgaaacct   3780

acagcatatt cttcacgcag agattttcat ctattatact ttatcaaaga ttggccatgt   3840

tccacttgga aatggcatgc aaaagcaatc atagagaaac ctgcgtaact ccatctgaca   3900

aattcaaaag agagagagag atcttgagag agaaatgctg ttcgttcaaa agtggagttg   3960

ttttaacaga tgccaattac ggtgtacagt ttaacagagt tttctgttgc attacgataa   4020

acattaattg gagtgcagct aacatgagta tcatcagact agtatcaagt gttctaaaat   4080

gaaatatgag aagatcctgt cacaattctt agatctggtg tccagcatgg atgaaacctt   4140

tgagtttggt ccctaaattt gcatgaaagc acaaggtaaa tattcatttg cttcaggagt   4200

ttcatgttgg atctgtcatt atcaaaagtg atcagcaatg aagaactggt cggacaaaat   4260

ttaacgttga tgtaatgaaa ttccagatgt aggcattccc cccaggtctt ttcatgtgca   4320

gattgcagtt ctgattcatt tgaataaaaa ggaacttgga aaacatg                 4367


<210>  2411
<211>  865
<212>  PRT
<213>  Homo sapiens

<400>  2411

Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn 
1               5                   10                  15


Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp 
            20                  25                  30


Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys 
        35                  40                  45


Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr 
    50                  55                  60


Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu 
65                  70                  75                  80


Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Pro Glu Thr Val 
                85                  90                  95


Ile Leu Gly Leu Lys Ile Val Tyr Tyr Glu Ala Gly Ile Ile Leu Cys 
            100                 105                 110


Cys Val Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly Tyr 
        115                 120                 125


Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His 
    130                 135                 140


Gln Arg Gln Lys Glu Asn Gly Pro Phe Leu Arg Lys Cys Phe Ala Ile 
145                 150                 155                 160


Ser Leu Leu Val Ile Cys Ile Ile Ile Ser Ile Gly Ile Phe Tyr Gly 
                165                 170                 175


Phe Val Ala Asn His Gln Val Arg Thr Arg Ile Lys Arg Ser Arg Lys 
            180                 185                 190


Leu Ala Asp Ser Asn Phe Lys Asp Leu Arg Thr Leu Leu Asn Glu Thr 
        195                 200                 205


Pro Glu Gln Ile Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp 
    210                 215                 220


Lys Ala Phe Thr Asp Leu Asn Ser Ile Asn Ser Val Leu Gly Gly Gly 
225                 230                 235                 240


Ile Leu Asp Arg Leu Arg Pro Asn Ile Ile Pro Val Leu Asp Glu Ile 
                245                 250                 255


Lys Ser Met Ala Thr Ala Ile Lys Glu Thr Lys Glu Ala Leu Glu Asn 
            260                 265                 270


Met Asn Ser Thr Leu Lys Ser Leu His Gln Gln Ser Thr Gln Leu Ser 
        275                 280                 285


Ser Ser Leu Thr Ser Val Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp 
    290                 295                 300


Pro Leu Cys Leu Val His Pro Ser Ser Glu Thr Cys Asn Ser Ile Arg 
305                 310                 315                 320


Leu Ser Leu Ser Gln Leu Asn Ser Asn Pro Glu Leu Arg Gln Leu Pro 
                325                 330                 335


Pro Val Asp Ala Glu Leu Asp Asn Val Asn Asn Val Leu Arg Thr Asp 
            340                 345                 350


Leu Asp Gly Leu Val Gln Gln Gly Tyr Gln Ser Leu Asn Asp Ile Pro 
        355                 360                 365


Asp Arg Val Gln Arg Gln Thr Thr Thr Val Val Ala Gly Ile Lys Arg 
    370                 375                 380


Val Leu Asn Ser Ile Gly Ser Asp Ile Asp Asn Val Thr Gln Arg Leu 
385                 390                 395                 400


Pro Ile Gln Asp Ile Leu Ser Ala Phe Ser Val Tyr Val Asn Asn Thr 
                405                 410                 415


Glu Ser Tyr Ile His Arg Asn Leu Pro Thr Leu Glu Glu Tyr Asp Ser 
            420                 425                 430


Tyr Trp Trp Leu Gly Gly Leu Val Ile Cys Ser Leu Leu Thr Leu Ile 
        435                 440                 445


Val Ile Phe Tyr Tyr Leu Gly Leu Leu Cys Gly Val Cys Gly Tyr Asp 
    450                 455                 460


Arg His Ala Thr Pro Thr Thr Arg Gly Cys Val Ser Asn Thr Gly Gly 
465                 470                 475                 480


Val Phe Leu Met Val Gly Val Gly Leu Ser Phe Leu Phe Cys Trp Ile 
                485                 490                 495


Leu Met Ile Ile Val Val Leu Thr Phe Val Phe Gly Ala Asn Val Glu 
            500                 505                 510


Lys Leu Ile Cys Glu Pro Tyr Thr Ser Lys Glu Leu Phe Arg Val Leu 
        515                 520                 525


Asp Thr Pro Tyr Leu Leu Asn Glu Asp Trp Glu Tyr Tyr Leu Ser Gly 
    530                 535                 540


Lys Leu Phe Asn Lys Ser Lys Met Lys Leu Thr Phe Glu Gln Val Tyr 
545                 550                 555                 560


Ser Asp Cys Lys Lys Asn Arg Gly Thr Tyr Gly Thr Leu His Leu Gln 
                565                 570                 575


Asn Ser Phe Asn Ile Ser Glu His Leu Asn Ile Asn Glu His Thr Gly 
            580                 585                 590


Ser Ile Ser Ser Glu Leu Glu Ser Leu Lys Val Asn Leu Asn Ile Phe 
        595                 600                 605


Leu Leu Gly Ala Ala Gly Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys 
    610                 615                 620


Gly Ile Asp Arg Met Asn Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys 
625                 630                 635                 640


Ser Pro Ala Gly Val Asn Leu Leu Ser Phe Ala Tyr Asp Leu Glu Ala 
                645                 650                 655


Lys Ala Asn Ser Leu Pro Pro Gly Asn Leu Arg Asn Ser Leu Lys Arg 
            660                 665                 670


Asp Ala Gln Thr Ile Lys Thr Ile His Gln Gln Arg Val Leu Pro Ile 
        675                 680                 685


Glu Gln Ser Leu Ser Thr Leu Tyr Gln Ser Val Lys Ile Leu Gln Arg 
    690                 695                 700


Thr Gly Asn Gly Leu Leu Glu Arg Val Thr Arg Ile Leu Ala Ser Leu 
705                 710                 715                 720


Asp Phe Ala Gln Asn Phe Ile Thr Asn Asn Thr Ser Ser Val Ile Ile 
                725                 730                 735


Glu Glu Thr Lys Lys Tyr Gly Arg Thr Ile Ile Gly Tyr Phe Glu His 
            740                 745                 750


Tyr Leu Gln Trp Ile Glu Phe Ser Ile Ser Glu Lys Val Ala Ser Cys 
        755                 760                 765


Lys Pro Val Ala Thr Ala Leu Asp Thr Ala Val Asp Val Phe Leu Cys 
    770                 775                 780


Ser Tyr Ile Ile Asp Pro Leu Asn Leu Phe Trp Phe Gly Ile Gly Lys 
785                 790                 795                 800


Ala Thr Val Phe Leu Leu Pro Ala Leu Ile Phe Ala Val Lys Leu Ala 
                805                 810                 815


Lys Tyr Tyr Arg Arg Met Asp Ser Glu Asp Val Tyr Asp Asp Val Glu 
            820                 825                 830


Thr Ile Pro Met Lys Asn Met Glu Asn Gly Asn Asn Gly Tyr His Lys 
        835                 840                 845


Asp His Val Tyr Gly Ile His Asn Pro Val Met Thr Ser Pro Ser Gln 
    850                 855                 860


His 
865


<210>  2412
<211>  510
<212>  DNA
<213>  Homo sapiens

<400>  2412
tgaactttgc ttttttagga cttgagacta caccttagca attttcccat aaatatacat     60

gaagaacttc tttattcttg tagcttgtag cttttccttt aaagtctttg agattggaag    120

acttggttta atttctcact ttagacctta acgtgtgact gtgagcaagg tagttaagct    180

ttccaagact cagttcttca tctgtacaca gggatccgat ggttcctata tgtggggtct    240

gcaggaccgg gagctcccta agggctagag ccatgtttct tcatggttta acctccattt    300

cttattgcag tgcctggtgc taggaagtgc ccaataaacc tgttgtgaag ctgcccaagc    360

tccttcttgc ccaaatgctt tggaaactgc caaaggacac tcagaggcca gggaatgtaa    420

caggcaagca taaatatgca gaagagatgg aaccaaaata gcgggcaggc agggccggcg    480

ctcgtggggg tcggtgatct ggagccgggc                                     510


<210>  2413
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  2413

Met Val Pro Ile Cys Gly Val Cys Arg Thr Gly Ser Ser Leu Arg Ala 
1               5                   10                  15


Arg Ala Met Phe Leu His Gly Leu Thr Ser Ile Ser Tyr Cys Ser Ala 
            20                  25                  30


Trp Cys 



<210>  2414
<211>  1106
<212>  DNA
<213>  Homo sapiens

<400>  2414
atggcccatc ttgtagaaag gagagatgcc agagcagcca tggaaaactc tggaggaagg     60

aatcctgagc ctcagagaac ctacacctac ccagctggcc acatacagcc tacacctacc    120

caactggagc aactaccttt gctgatacgc agcgaaggag aaagtacctg cggaaacaag    180

gatttcaggg aattgcttta tggagcacaa gactacatgt caggtctaga tgttatgaca    240

gactccaact gctgtctgtc tcgcaagaag atcaggaaga cagagagtgg tataccacat    300

cagtgtcaga tttgtaagaa agcgtttaaa cacgagcatc accttaacga gcactcaagg    360

cttcactcgg gcaagaagcc ctatcagtgt gataaatgtg gcaagcgctt ctcacactcc    420

ggctcgtact cgcagcacag gaatcacagg tattcctact gcaagcggga gacggaggag    480

cgggaagccg cggagagcaa ggcacgcgag aaagggcact tggaacccac cctgctgatg    540

aaccgggctt acctgcagag cattatccct ccagggtact ctgactcgga ggagaggaag    600

aatggcgacg aggagttcga ggcggaagag gaagaaagtg aaaataaaag tatggatacg    660

gatcccgaaa cgatacgaga taaagaagaa actggagatc actccatgga cgatagttcg    720

gaggatggga aaatggaaac caaatcagac cacgaggaag acaatatgga acgtggcatg    780

gactaaacta ctgcatttga agcttccttt ttttttttcc agtagtattg ttacctgctt    840

gaaaacattg ctgtgttaag cggttcatgc acatgcctga cgcttccaga aagctgtgga    900

gagggacaga aggggtggtt cagccaagac agatgtagac agagttggag ctgggtattg    960

ttaaaaactg cattatgcaa aaattttgta cagtgttaag gcctaaaaac tgtgtggttc   1020

agagactaat tcctgtgttt aatagcattt atactttaag cacaactaga aaattgtaaa   1080

aattgcactc tacttacgta tcacta                                        1106


<210>  2415
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  2415

Met Ala His Leu Val Glu Arg Arg Asp Ala Arg Ala Ala Met Glu Asn 
1               5                   10                  15


Ser Gly Gly Arg Asn Pro Glu Pro Gln Arg Thr Tyr Thr Tyr Pro Ala 
            20                  25                  30


Gly His Ile Gln Pro Thr Pro Thr Gln Leu Glu Gln Leu Pro Leu Leu 
        35                  40                  45


Ile Arg Ser Glu Gly Glu Ser Thr Cys Gly Asn Lys Asp Phe Arg Glu 
    50                  55                  60


Leu Leu Tyr Gly Ala Gln Asp Tyr Met Ser Gly Leu Asp Val Met Thr 
65                  70                  75                  80


Asp Ser Asn Cys Cys Leu Ser Arg Lys Lys Ile Arg Lys Thr Glu Ser 
                85                  90                  95


Gly Ile Pro His Gln Cys Gln Ile Cys Lys Lys Ala Phe Lys His Glu 
            100                 105                 110


His His Leu Asn Glu His Ser Arg Leu His Ser Gly Lys Lys Pro Tyr 
        115                 120                 125


Gln Cys Asp Lys Cys Gly Lys Arg Phe Ser His Ser Gly Ser Tyr Ser 
    130                 135                 140


Gln His Arg Asn His Arg Tyr Ser Tyr Cys Lys Arg Glu Thr Glu Glu 
145                 150                 155                 160


Arg Glu Ala Ala Glu Ser Lys Ala Arg Glu Lys Gly His Leu Glu Pro 
                165                 170                 175


Thr Leu Leu Met Asn Arg Ala Tyr Leu Gln Ser Ile Ile Pro Pro Gly 
            180                 185                 190


Tyr Ser Asp Ser Glu Glu Arg Lys Asn Gly Asp Glu Glu Phe Glu Ala 
        195                 200                 205


Glu Glu Glu Glu Ser Glu Asn Lys Ser Met Asp Thr Asp Pro Glu Thr 
    210                 215                 220


Ile Arg Asp Lys Glu Glu Thr Gly Asp His Ser Met Asp Asp Ser Ser 
225                 230                 235                 240


Glu Asp Gly Lys Met Glu Thr Lys Ser Asp His Glu Glu Asp Asn Met 
                245                 250                 255


Glu Arg Gly Met Asp 
            260


<210>  2416
<211>  436
<212>  DNA
<213>  Homo sapiens

<400>  2416
agatgaggtt cttgctatgt tgcctaggct ggtcttgaac ttctggcctc aagaaatcct     60

cctcctgatc ctcctacctc agccttccaa agtgttggga ttacagcact ggctagaact    120

tccatccctg tggtgaataa gagtgatgaa agtggacacc atcgtattat tgaattgaag    180

ggacacctct gaaaacgtgt ttagagagag agtgaagaat gagggtgtac ctggcggagc    240

caccatcctc tgccacttct gaaacaagca ggtcttcagg cagtctcggg gactgaggtt    300

gtaagtttta tgtctcgaca tcagttcctg cattggctcc aatattacac acaactgcaa    360

gaagttcaaa gacattggca tttcactact tcataacact aattacaata aataatgcta    420

acagctggaa tcaagt                                                    436


<210>  2417
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  2417

Met Leu Pro Arg Leu Val Leu Asn Phe Trp Pro Gln Glu Ile Leu Leu 
1               5                   10                  15


Leu Ile Leu Leu Pro Gln Pro Ser Lys Val Leu Gly Leu Gln His Trp 
            20                  25                  30


Leu Glu Leu Pro Ser Leu Trp 
        35


<210>  2418
<211>  368
<212>  DNA
<213>  Homo sapiens

<400>  2418
ttgctgccct ggtctgttgc gagcatgtca aggagatttc tcacttcctc acaggacgtg     60

tgggatcatc tcccagatga actaccagtt cctaagtatt tgtctgaagc actggctaga    120

acttccatcc ctgtggtgaa taagagtgat gaaagtggac accatcgtat tattgaattg    180

aagggattca aacctcttct gtgataatca tagaactgta gcatcagaag gcaattccct    240

aagtgtggtc tgcccacatc cctggtggta agccaaatga tcgtaagtgg tagagcggca    300

attactttta aaaaatttga cagtcatata tctatttcaa tgtatagcaa atatagaatt    360

ggaacatc                                                             368


<210>  2419
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  2419

Met Ser Arg Arg Phe Leu Thr Ser Ser Gln Asp Val Trp Asp His Leu 
1               5                   10                  15


Pro Asp Glu Leu Pro Val Pro Lys Tyr Leu Ser Glu Ala Leu Ala Arg 
            20                  25                  30


Thr Ser Ile Pro Val Val Asn Lys Ser Asp Glu Ser Gly His His Arg 
        35                  40                  45


Ile Ile Glu Leu Lys Gly Phe Lys Pro Leu Leu 
    50                  55


<210>  2420
<211>  5367
<212>  DNA
<213>  Homo sapiens

<400>  2420
gcagactaga cgctgagcgc tcccgtgcgc agcgccccac gcagccggga cgcggcgccg     60

ctctgcgggt ggaaccgccg cgcgctcccg gcctcgggag ctgagcccga gagaacttcg    120

ctgccttcgg gtcgccgctc ccgctttcca ctgtggaatg tgcagcttgg gatagagaga    180

aaccagggtt tggggagcgg tcctcctgga gactttctct ctgcaagtct ccaaggttaa    240

gcaattctga cccactggaa ttcccagagc ctgggagtta agcctaaaac gctctgttgc    300

tttaagcggc gcggtgggga gtcgctggac actccttatt ttggttttac attaaaaaga    360

aggcggacga gaagatgttg taggtgactt cctagctgtg ttaagttgct cctgggctgt    420

gaatggtgtt aatttctgaa gtgggcggct ccaaaaactt aacaaggaaa gctcaggtaa    480

cggaggcctt ggaaagagac tctgcgtcag gtcacccagc agagatcagc aatccttggc    540

tcactgagga ggtttggatt tgcctcaaag ggcactgcaa aaattgaaca gaggaatccc    600

aaggaagctg cctgaatttg cctgtatact ctcgttctgc gacttataaa ggaccagaca    660

aatcaaatta gtggttttgg tttccgccag ctgtggatgc ctttgacatt atgaccgcag    720

aggattccac cgcagccatg agcagtgact cggccgccgg gtcctccgcc aaggtgcccg    780

agggcgtggc gggcgcgccc aacgaggcag cactgctggc gctgatggag cgcacgggct    840

acagcatggt gcaagagaac gggcagcgca agtacggcgg cccaccgccc ggctgggagg    900

gcccgcaccc gcagcgtggc tgcgaggtct tcgtgggcaa gatcccgcgc gacgtgtacg    960

aggacgagct ggtgcccgtg ttcgaggccg tgggccgcat ctacgagctg cgcctcatga   1020

tggactttga cggcaagaac cgcggctacg ccttcgtcat gtactgccac aagcacgagg   1080

ccaagcgcgc agtgcgtgag ctcaacaact acgagatccg cccgggccgc ctgctcggcg   1140

tgtgctgcag cgtggacaac tgccgcctct tcatcggcgg gatccccaag atgaagaagc   1200

gcgaggaaat cctggaggag attgccaagg tcaccgaggg cgtgctggac gtgatcgtct   1260

acgccagcgc ggccgacaag atgaagaacc gcggcttcgc cttcgtggag tacgagagcc   1320

accgcgcggc tgccatggct cgccgcaagc tcatgcctgg ccgcatccag ctgtggggcc   1380

accagatcgc cgtggactgg gccgaacctg agatcgacgt ggacgaggac gtgatggaga   1440

ccgtgaagat cctctacgtg cgcaacctca tgatcgagac caccgaggac accatcaaga   1500

agagcttcgg ccagttcaac cccggctgcg tggagcgcgt caagaagatc cgcgactacg   1560

ccttcgtgca cttcaccagc cgcgaggatg ccgtgcatgc catgaacaac ctcaacggca   1620

ctgagctgga gggctcgtgc ctggaggtca cgctggccaa gcccgtggac aaggagcagt   1680

actcgcgcta ccagaaggca gccaggggcg gcggcgcggc tgaggcagcg cagcagccca   1740

gctacgtgta ctcctgcgac ccctacacac tggcctacta cggctacccc tacaacgcgc   1800

tcattgggcc caacagggac tactttgtga aagatacaat cctagaaact caccctgcaa   1860

gtttgcctct tgtactaaga agacatgctt aggatgcaaa tctaggctga aatagaatgt   1920

tggaagcatc tttaccagcc tattaaagag caaaggtgta gccacctgca attaagactg   1980

gggcagttaa atgccgagaa ccgagggctg aggtctgcct ccagcaccgt cactgttggt   2040

tgctgatcat cttttgtgtt gttattacaa gcaggcagca taagaggccg agggcgaggt   2100

gcagctggca acagagcccc agggcctagg ggttcctacc tcgggggata ttctgctggt   2160

cgtggtatat atagccgata tcatgaaggg aaaggaaagc agcaagaaaa aggatatgaa   2220

ctggtgccga atttggaaat ccctaccgtc aacccagttg ccattaaacc tggtacagta   2280

gccatccctg ccattggggc tcagtattcc atgtttccag cagctccagc ccctaaaatg   2340

attgaagatg gcaaaatcca cacagtggag cacatgatca gccccattgc tgtgcagcca   2400

gacccagcca gtgctgctgc cgccgcagcc gcggccgcag ccgccgcagc cgctgtcatt   2460

cccactgtgt cgacgccacc acctttccag ggccgcccaa taactccagt atacacggtg   2520

gctccaaacg ttcagagaat tcctactgcc gggatctacg gggccagtta cgtgccattt   2580

gctgctccag ctacagccac gatcgccaca ctacagaaga acgcggcagc cgcggccgcc   2640

atgtatggag gatacgcagg ctacatacct caggccttcc ctgctgctgc cattcaggtc   2700

cccatccccg acgtctacca gacatactga ggctggtgac cagcacgaag acagaccaca   2760

caaacaccac tgaaggaacg cttgactatt tatgaagaag gaacatgttg gattcacaca   2820

tgcaacctga aagtgaagaa tgttagcaga tttatttctg aattatttta tatacatgaa   2880

gttttcacta gttttttaag actattttca acttagcatg cctacgttca tacatttcca   2940

aaagacttgc aatggttcgt gccttcattc catcttttaa aaatttgtat gctgtactac   3000

atttgtatag aggtttttgt tgttgttttt ttaaggatat attttcagta tgaaggttat   3060

tttcttaact tctgcactcc agagatttct attttgtagt accttcaata atatatcaac   3120

tatatattaa aaaagcacac ttgaggagct agggaactat tttgaaaaat atatacaata   3180

tttaaagata caaacagtag tgcttaaaaa tactacataa agcattattt taaaggttat   3240

actggaaagt gcaattttaa aatgagtaaa acctctgtat ttctgctggc attaagggtt   3300

gatggtgtta ccatgtatca tcatggcggt actatttttt aaaagaaatt aaacactgga   3360

tctctcctta agccaacatt gaaaagactt gccgcacttc tgagtccaaa cactggaaag   3420

ctctcctttg ccaccgttag ccggggctca ttctccatgt gccttagcct taaacatgcc   3480

cccactccca catctctcac cctgtcccct cctccccaga ttcccaatcc caccgcaatg   3540

tttggcaagc ctaggactga taagtagctc tgatagagga gctggtggct tttatacttc   3600

ttcctgggtt tttgttgggg tttgttgttt cgttgttttt tgtttttttt tttgtttggt   3660

tggggaagta ttgtcttcta cgtgtgctat tttcagtagc agagtaagca caaggtttta   3720

atcgagttgc ataagacacc tttgcatagc tatttaattg cccaatgtaa aactttaatg   3780

ccatttctaa tgcttttatt catttttgaa gtatgagttt gtagggacaa agaatgtatg   3840

ttatcgtaga caagaccccc agagactctt ttcagcagaa agttatgctt ctagttgcct   3900

taccatgttt cttgcaaaac tgtccatggt cctcaagggt gttggaaaca ttatgtttat   3960

taaatgggcc tctcttcctt tgctgtgcac ttgatgggtg aactggattg gggtgtgcac   4020

atccaggagg aggaggagag acctgtagaa gtttaaagat agtttgtaaa tatcttctaa   4080

tgcttgtttt tagtcctttt atgttggaga agttcatggt atgtagttta atgcaaaatg   4140

aaaccatttt atttcaatgt tattaaaaag gtttgtttta ttaggaagtt aatgtattgt   4200

tgcagtgttt tgtgcctgtt taaaggcttt tgtttagcag agtgaatgta aaatacagta   4260

aaatgttaag attgtcatct actttttaaa aaaaaatatc aacttggaat tgttttttaa   4320

aggctcaatc aaggaagtga ggtgtgcaat aaggtagcaa gtaaaacgca gttgcgtttt   4380

tatgtcatgt tagagatcca tacaattttc cactcacggg atttttgttg atggctgaat   4440

tcttgtggat tcataagagg atcatgccct tagcaagtac ttttgttttg ttttaaatta   4500

agagattccc aaatgccttt ttccccctca tcttgaaatg agatgagttt ttatgtgtaa   4560

gcaatattta tttaactatt ctataaaatt attgagtgcc tactgaggcc tttaagcacc   4620

gctaacattc ctttccatca ttcttttaaa tgacataaaa taattgtgca atgttcctga   4680

tgatgtaccc cacaagctgc attcaaactc aaatctgtgg gaatgagtga ctcgacaaaa   4740

tgtaattcgg atcagatcct catcccctga ctgtgtgaaa aaagtactct ccttctagtg   4800

aaggattgtc acagagtttc actggatgaa actatgaccc agtattctta ctgtatttta   4860

catatgcctg taaattattt gcaaaaaaga agaagaagag gaagaaagaa aagaaagaaa   4920

agaaagaaag aaagaaagaa agaaagaaag aaagaaagaa agaaagaaag aaagaaagaa   4980

aaagaaagaa agaataaaaa aaaatgataa catggcaacc accaaactcc cttaaaaaca   5040

aacattggtg acatggccaa ttaagtatca gtgagcctcc tatctgggac ttatctgttc   5100

ctattgtttc aaaaccattt catgtacact actgaggtaa gtttataact tgaaatgtga   5160

actttttttt tttttagtgt taagaacaaa ctatataaat gtaaaaaaaa agttttagag   5220

ttctgttttc aaacattgct agtggtttag ttaactttag ctgctttata tttgaaaagc   5280

ttttatttag atcttgctcc atttacagta cattcttagg atgtatgtag taaataaagc   5340

tttctttaaa gcaatcgcaa gacctta                                       5367


<210>  2421
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  2421

Met Thr Ala Glu Asp Ser Thr Ala Ala Met Ser Ser Asp Ser Ala Ala 
1               5                   10                  15


Gly Ser Ser Ala Lys Val Pro Glu Gly Val Ala Gly Ala Pro Asn Glu 
            20                  25                  30


Ala Ala Leu Leu Ala Leu Met Glu Arg Thr Gly Tyr Ser Met Val Gln 
        35                  40                  45


Glu Asn Gly Gln Arg Lys Tyr Gly Gly Pro Pro Pro Gly Trp Glu Gly 
    50                  55                  60


Pro His Pro Gln Arg Gly Cys Glu Val Phe Val Gly Lys Ile Pro Arg 
65                  70                  75                  80


Asp Val Tyr Glu Asp Glu Leu Val Pro Val Phe Glu Ala Val Gly Arg 
                85                  90                  95


Ile Tyr Glu Leu Arg Leu Met Met Asp Phe Asp Gly Lys Asn Arg Gly 
            100                 105                 110


Tyr Ala Phe Val Met Tyr Cys His Lys His Glu Ala Lys Arg Ala Val 
        115                 120                 125


Arg Glu Leu Asn Asn Tyr Glu Ile Arg Pro Gly Arg Leu Leu Gly Val 
    130                 135                 140


Cys Cys Ser Val Asp Asn Cys Arg Leu Phe Ile Gly Gly Ile Pro Lys 
145                 150                 155                 160


Met Lys Lys Arg Glu Glu Ile Leu Glu Glu Ile Ala Lys Val Thr Glu 
                165                 170                 175


Gly Val Leu Asp Val Ile Val Tyr Ala Ser Ala Ala Asp Lys Met Lys 
            180                 185                 190


Asn Arg Gly Phe Ala Phe Val Glu Tyr Glu Ser His Arg Ala Ala Ala 
        195                 200                 205


Met Ala Arg Arg Lys Leu Met Pro Gly Arg Ile Gln Leu Trp Gly His 
    210                 215                 220


Gln Ile Ala Val Asp Trp Ala Glu Pro Glu Ile Asp Val Asp Glu Asp 
225                 230                 235                 240


Val Met Glu Thr Val Lys Ile Leu Tyr Val Arg Asn Leu Met Ile Glu 
                245                 250                 255


Thr Thr Glu Asp Thr Ile Lys Lys Ser Phe Gly Gln Phe Asn Pro Gly 
            260                 265                 270


Cys Val Glu Arg Val Lys Lys Ile Arg Asp Tyr Ala Phe Val His Phe 
        275                 280                 285


Thr Ser Arg Glu Asp Ala Val His Ala Met Asn Asn Leu Asn Gly Thr 
    290                 295                 300


Glu Leu Glu Gly Ser Cys Leu Glu Val Thr Leu Ala Lys Pro Val Asp 
305                 310                 315                 320


Lys Glu Gln Tyr Ser Arg Tyr Gln Lys Ala Ala Arg Gly Gly Gly Ala 
                325                 330                 335


Ala Glu Ala Ala Gln Gln Pro Ser Tyr Val Tyr Ser Cys Asp Pro Tyr 
            340                 345                 350


Thr Leu Ala Tyr Tyr Gly Tyr Pro Tyr Asn Ala Leu Ile Gly Pro Asn 
        355                 360                 365


Arg Asp Tyr Phe Val Lys Asp Thr Ile Leu Glu Thr His Pro Ala Ser 
    370                 375                 380


Leu Pro Leu Val Leu Arg Arg His Ala 
385                 390


<210>  2422
<211>  1046
<212>  DNA
<213>  Homo sapiens

<400>  2422
gcagactaga cgctgagcgc tcccgtgcgc agcgccccac gcagccggga cgcggcgccg     60

ctctgcgggt ggaaccgccg cgcgctcccg gcctcgggag ctgagcccga gagaacttcg    120

ctgccttcgg gtcgccgctc ccgctttcca ctgtggaatg tgcagcttgg gatagagaga    180

aaccagggtt tggggagcgg tcctcctgga gactttctct ctgcaagtct ccaaggttaa    240

gcaattctga cccactggaa ttcccagagc ctgggagtta agcctaaaac gctctgttgc    300

tttaagcggc gcggtgggga gtcgctggac actccttatt ttggttttac attaaaaaga    360

aggcggacga gaagatgttg taggtgactt cctagctgtg ttaagttgct cctgggctgt    420

gaatggtgtt aatttctgaa gtgggcggct ccaaaaactt aacaaggaaa gctcaggtaa    480

cggaggcctt ggaaagagac tctgcgtcag gtcacccagc agagatcagc aatccttggc    540

tcactgagga ggtttggatt tgcctcaaag ggcactgcaa aaattgaaca gaggaatccc    600

aaggaagctg cctgaatttg cctgtatact ctcgttctgc gacttataaa ggaccagaca    660

aatcaaatta gtggttttgg tttccgccag ctgtggatgc ctttgacatt atgaccgcag    720

aggattccac cgcagccatg agcagtgact cggccgccgg gtcctccgcc aaggtgcccg    780

agggcgtggc gggcgcgccc aacgaggcag cactgctggc gctgatggag cgcacgggct    840

acagcatggt gcaagagaac gggcagcgca agtacggcgg cccaccgccc ggctgggagg    900

gcccgcaccc gcagcgtggc tgcgaggtct tcgtgggcaa gatcccgcgc gacgtgtacg    960

aggacgagct ggtgcccgtg ttcgaggccg tgggccgcat ctacgagctg cgcctcatga   1020

tggactttga cggcaagaac cgcggc                                        1046


<210>  2423
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  2423

Met Val Leu Ile Ser Glu Val Gly Gly Ser Lys Asn Leu Thr Arg Lys 
1               5                   10                  15


Ala Gln Val Thr Glu Ala Leu Glu Arg Asp Ser Ala Ser Gly His Pro 
            20                  25                  30


Ala Glu Ile Ser Asn Pro Trp Leu Thr Glu Glu Val Trp Ile Cys Leu 
        35                  40                  45


Lys Gly His Cys Lys Asn 
    50


<210>  2424
<211>  899
<212>  DNA
<213>  Homo sapiens

<400>  2424
ataaacaggt aaggcggagg gggtggggcg cggattgcgg acatctgggt ttcttgggaa     60

ttgggatggg gtgggggttc gagccaactc cccagagagc aggcaaggtg aagcgagggc    120

ttggctgctg tttctaaatg cagtgttttt ttgttccctt tctagaaacc ctccgtaact    180

ctaggtcaga gcgcactaaa atgagccact tctgaacgag cagcgcccag gccccaggcc    240

ctgctgcgaa ggccccggca aaggtcaggg ccccgtccgc gtgacgctcc tgcctgcgcg    300

cggccaagcc atgctcggcc ccagctcagg taacggaggc cttggaaaga gactctgcgt    360

caggtcaccc agcagagatc agcaatcctt ggctcactga ggaggtttgg atttgcctca    420

aagggcactg caaaaattga acagaggaat cccaaggaag ctgcctgaat ttgcctgtat    480

actctcgttc tgcgacttat aaaggaccag acaaatcaaa ttagtggttt tggtttccgc    540

cagctgtgga tgcctttgac attatgaccg cagaggattc caccgcagcc atgagcagtg    600

actcggccgc cgggtcctcc gccaaggtgc ccgagggcgt ggcgggcgcg cccaacgagg    660

cagcactgct ggcgctgatg gagcgcacgg gctacagcat ggtgcaagag aacgggcagc    720

gcaagtacgg cggcccaccg cccggctggg agggcccgca cccgcagcgt ggctgcgagg    780

tcttcgtggg caagatcccg cgcgacgtgt acgaggacga gctggtgccc gtgttcgagg    840

ccgtgggccg catctacgag ctgcgcctca tgatggactt tgacggcaag aaccgcggc     899


<210>  2425
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  2425

Met Thr Ala Glu Asp Ser Thr Ala Ala Met Ser Ser Asp Ser Ala Ala 
1               5                   10                  15


Gly Ser Ser Ala Lys Val Pro Glu Gly Val Ala Gly Ala Pro Asn Glu 
            20                  25                  30


Ala Ala Leu Leu Ala Leu Met Glu Arg Thr Gly Tyr Ser Met Val Gln 
        35                  40                  45


Glu Asn Gly Gln Arg Lys Tyr Gly Gly Pro Pro Pro Gly Trp Glu Gly 
    50                  55                  60


Pro His Pro Gln Arg Gly Cys Glu Val Phe Val Gly Lys Ile Pro Arg 
65                  70                  75                  80


Asp Val Tyr Glu Asp Glu Leu Val Pro Val Phe Glu Ala Val Gly Arg 
                85                  90                  95


Ile Tyr Glu Leu Arg Leu Met Met Asp Phe Asp Gly Lys Asn Arg 
            100                 105                 110


<210>  2426
<211>  2967
<212>  DNA
<213>  Homo sapiens

<400>  2426
agacgctgag cgctcccgtg cgcagcgccc cacgcagccg ggacgcggcg ccgctctgcg     60

ggtggaaccg ccgcgcgctc ccggcctcgg gagctgagcc cgagagaact tcgctgcctt    120

cgggtcgccg ctcccgcttt ccactgtgga atgtgcagct tgggatagag agaaaccagg    180

gtttggggag cggtcctcct ggagactttc tctctgcaag tctccaaggt taagcaattc    240

tgacccactg gaattcccag agcctgggag ttaagcctaa aacgctctgt tgctttaagc    300

ggcgcggtgg ggagtcgctg gacactcctt attttggttt tacattaaaa agaaggcgga    360

cgagaagatg ttgtaggtga cttcctagct gtgttaagtt gctcctgggc tgtgaatggt    420

gttaatttct gaagtgggcg gctccaaaaa cttaacaagg aaagctcagg taacggaggc    480

cttggaaaga gactctgcgt caggtcaccc agcagagatc agcaatcctt ggctcactga    540

ggaggtttgg taagttggca tcatcttcac catgactcaa atgcacataa cccggtggcg    600

ggggagaaaa gtgggtgaac atcacatagc gacatcaaaa tgctaatcct tgccaccccc    660

ctttgttttt gtttttacaa acgtattgtt gttgtgtttg tttaatttac taggccagag    720

tgccctgtat gtttgtaagc acaaatgtcc tcagaggact cccacagcca aaaagaatga    780

cagaggtgta tttgaatgat ttcagtgaaa ctcttttaat actgatttca tgaaaatgtc    840

tggtggtggg ttcttcctgt agcattactg catatcatca actagaatgc atcccccgcc    900

cttcacacat acaatttaac atgtctgaaa ttcggtgcac cttatgcaaa caggtctggt    960

gaaatacagc atttctctga taatccccaa atgaccagca ttaagtattc cctaccttct   1020

atttttcaca caatacaaat gttttttttt tttttttctt tttagagggt tgaattttta   1080

agggtaagaa atgcatagtc tgatgagtag atgattagta agaagtctgt gcttaccaaa   1140

gaaagaattt aggtttcctt ttttgttttt gtttttgaaa tgaagtcaca ttatcaccca   1200

ggctggagtg cagtggcacg atctcggctc actgcaacct ctgctcctgg gtttatgtga   1260

ttctcctgcc tcagcctccc gagtagctgg gactgactac aggcacgcac catcacacct   1320

ggctaattat tgtattttta gtcgagatgg ggtttcacca tgttggccag gctggtctca   1380

aactcctgac ctcaagtgat ctgcccacct cagcctccca aagtgctggg attataggca   1440

tgagccacca cacccagcca gaatttagtt ttctaatact gaaagaaaaa cttttttttt   1500

tggtgacttc atatgatagt cttgagatga gcaccccaag gaccttgtaa atagtgggcg   1560

ctggcactca gaacagccca tgtgagataa tgaagcagcc ttccagacat aagatcccag   1620

aatcagacac ttatccaagg ttcccctcct gcaatcagcg ggtaggagtt tgcaatgaaa   1680

acactccatg ctatgtccca gagtgactcg ttcatttatc cgtgaaagca gagtccaaat   1740

ccatgttcat gttaaatgtg cagaaaaata gcatcttgag agttaatgcc acagaatggg   1800

catgattccc taagccacat ttgcctgatt gagacagact ttaacatttg caaaacctcc   1860

atgttatgag accctatagg tgatagtaca tgatctgtag ggatacaagt aaatccatta   1920

acaaacattt tttgagcacc tgctatgtgc caggctctgt gctaggctct gtgctagatg   1980

tagcataatt aagaagtaat taggacagaa aggattgctg tccccacagg gctactttag   2040

tagtcacaga agatattaaa taatacatta acagagtaat gagtgggctg atgaagaact   2100

gtaaggagtt aagagtctaa aacaagaaaa cctaagctag ccagagtggc tcacgcctgc   2160

aatcccagca catagggagg ccagggtgag aggatcactt gagctcagga gttcaagacc   2220

aacctgggca acataatgag acctgtctct acaaaaattt aaaaattgtc atcccattct   2280

ctactggaaa ataaaaaatt agctgggtat gctggcacgc acccatagtc ccagctactt   2340

gggaggctgc agtgagagaa ttgcttaggc ctgggaggtt gaggctacag tgagccaaga   2400

ttgcatcact gcagtctagc cagggcaaca gagcaagacc ctatctcgaa aaaataaata   2460

aataaaaaca agaggaccta acataatctg agtcaggagg tgactattgg gaaggttgct   2520

tggagtttga atggcattct aactgagacc tggaggatag gcagaggggg attggagaca   2580

ggcggcagtg gctacattaa acagcctttg caggggccca gtatggagag agtgttgggg   2640

tcaaggaata gcatgagcta tggggggaaa gggaaaggga gagggagagg cttcagagaa   2700

caggtgtctc ttgtaaaatg aaaacttagt caaatttctg gaagaatctt taaaacctct   2760

taaagagatt gatttcagac tgatgatcag atttttttgt ttttgtggtt cagacagaaa   2820

tcttaccttg tgtatcagca ttattcccta gagttagagc ccaagtattg ctcccctgct   2880

aatcctttga attctcccca aatctatgtt cttaatttac ctcacctacc tccccaagga   2940

aggtaatcag cttctagtaa gaggtgg                                       2967


<210>  2427
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  2427

Met Val Leu Ile Ser Glu Val Gly Gly Ser Lys Asn Leu Thr Arg Lys 
1               5                   10                  15


Ala Gln Val Thr Glu Ala Leu Glu Arg Asp Ser Ala Ser Gly His Pro 
            20                  25                  30


Ala Glu Ile Ser Asn Pro Trp Leu Thr Glu Glu Val Trp 
        35                  40                  45


<210>  2428
<211>  592
<212>  DNA
<213>  Homo sapiens

<400>  2428
agacgctgag cgctcccgtg cgcagcgccc cacgcagccg ggacgcggcg ccgctctgcg     60

ggtggaaccg ccgcgcgctc ccggcctcgg gagctgagcc cgagagaact tcgctgcctt    120

cgggtcgccg ctcccgcttt ccactgtgga atgtgcagct tgggatagag agaaaccagg    180

gtttggggag cggtcctcct ggagactttc tctctgcaag tctccaaggt taagcaattc    240

tgacccactg gaattcccag agcctgggag ttaagcctaa aacgctctgt tgctttaagc    300

ggcgcggtgg ggagtcgctg gacactcctt attttggttt tacattaaaa agaaggcgga    360

cgagaagatg ttgtaggtga cttcctagct gtgttaagtt gctcctgggc tgtgaatggt    420

gttaatttct gaagtgggcg gctccaaaaa cttaacaagg aaagatatct tgggaatatt    480

gaatatattc acagatggta gaatcggagt ttgcagttct gctttctttg ccctgacctt    540

gtttgagacg tgcttgcttc tgatatgctg attccacgtt gcaaaagtga aa            592


<210>  2429
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  2429

Met Val Leu Ile Ser Glu Val Gly Gly Ser Lys Asn Leu Thr Arg Lys 
1               5                   10                  15


Asp Ile Leu Gly Ile Leu Asn Ile Phe Thr Asp Gly Arg Ile Gly Val 
            20                  25                  30


Cys Ser Ser Ala Phe Phe Ala Leu Thr Leu Phe Glu Thr Cys Leu Leu 
        35                  40                  45


Leu Ile Cys 
    50


<210>  2430
<211>  2661
<212>  DNA
<213>  Homo sapiens

<400>  2430
gcttcggccc ctcctcccgc cctccccacg gagagccgag cagcagccct agagcctctc     60

gcaagtctct ctcacacttc cccgccctcg ccccaaagga gcagcagctc cttcttgcct    120

ctccattgcc gccgccgcac cggcggagct cctctctcgc gcgtctctcc tccgatggag    180

ctcgggcgcc gccgacgccg ccgctgcccc gaaccctgag cggggccgcc ccggtcggag    240

gaacgcgccg cccagtccga gggcgcagag cgccaggagc acgcggaggg ctggggcgcg    300

ggctccggga acgagaaagt gcagctctct cgggtcactg ggccggcggc ggggggacta    360

tggctctgaa ggacacgggc agcggcggca gcaccatcct gcccattagc gagatggttt    420

cctcgtccag ctcgcccggc gcgtcggccg ccgccgcccc ggggccctgc gcaccctcgc    480

ccttccctga agtagtggag ctgaacgtag gcggccaggt ttatgtgacc aagcactcga    540

cgctgctcag cgtcccggac agtactttgg ccagcatgtt ctcgccctct agtccccgtg    600

gcggcgcccg gcgccggggc gagctgccca gggacagccg ggcgcgcttc ttcatcgacc    660

gggacggctt ccttttcagg tacgtgctgg attatctgcg ggacaagcaa ctcgcgctgc    720

cggagcactt ccccgagaag gagcggctgc tgcgcgaggc cgagtatttc cagctcaccg    780

acttggtcaa gctgctgtcg cccaaggtca ccaagcagaa ctctctcaac gacgagggct    840

gccagagcga cctggaggac aacgtctcgc agggtagcag cgacgcgctg ctgctgcgcg    900

gggcggcggc cgccgtgccc tcgggcccgg gagcgcacgg tggtggcggc ggcggcggcg    960

cgcaggacaa gcgctcgggc ttcctcacgc tgggctaccg gggctcctac accaccgtgc   1020

gcgacaacca ggccgacgcc aaattccggc gtgtggcgcg catcatggtg tgcgggcgca   1080

tcgcgctggc caaggaggtc ttcggggaca cgctcaacga gagccgcgac cccgaccggc   1140

agccggagaa gtacacgtcc cgcttctacc tcaagttcac ctacttggag caggcctttg   1200

atcgcctgtc cgaggccggc ttccacatgg tggcgtgtaa ctcctcgggc accgccgcct   1260

tcgtcaacca gtaccgcgac gacaagatct ggagcagcta caccgagtac attttcttcc   1320

gaccacctca gaaaatagta tcacctaaac aagaacatga agataggaaa catgacaaag   1380

tcactgataa aggaagtgaa agtgggactt cctgtaatga gctctccact tccagttgtg   1440

acagccattc agaggcaagc actccccagg acaacccatc cagtgcccag caggcaacag   1500

ctcaccaacc taacacttta acattggatc gcccctctaa aaaagcacct gtacaatgga   1560

tacccccacc agacaaacgc agaaacagtg aactctttca gaccctcatc agcaagtccc   1620

gggaaacaaa tctgtccaaa aagaaagtct gtgagaagct aagtgtggaa gaagaaatga   1680

aaaagtgtat tcaggatttt aaaaaaatcc acattccaga ttattttcca gagcgcaaac   1740

gccaatggca atctgaactg ttgcagaagt atgggttata gtaattgtca cattcctgca   1800

gtattttgat gacattcaat gtttactaca gtgtcaccac ctgactgatg tcctaacaat   1860

ggtcagtgtg attcttgctg ctcttccttg ttgtgaacag tggatgtggg acagtatttt   1920

cttttatgtt ttagttgttg ttctttttag aaacatgatt aaaaaggaaa aaatattaaa   1980

tcaataagtg ttaaatcaaa atggaatatc tgattcaaac cattttacaa gaatgaaagt   2040

aaaatgtgca tgatcaagct tagtatcttg gtttttgaac tctggtcaac tggatatgtt   2100

tgtcattttg taacttacca aaaacaaacc atcatatcat accaactaaa atgatatatg   2160

gatgaagcaa catcaagtaa aattttagac gatggctata ggacccaaat ctaaagctgt   2220

ctaaatgtta attcaatgaa acaagtatta tttttgcatg aatacaatgt tacaaataaa   2280

tcacaagaaa tagggaagat ctgtttgttg cttggaaaga aaaaaattac aaaaaaaagc   2340

aaaaaaaaat gttttagaca aagcctataa atgtaagctg tctaggagat tgaattttct   2400

ttgttctgga tctgtgactt ttttgtgtat gtgtatggtg tttatgtata ttaagatggt   2460

gtaaatatgc cttatactgt tatttatggc atcaacattc atttactaat gctagtcatg   2520

attattactg tgaaatgagt cttacatcgg gctgtgaaaa ttggtataat gatgctttga   2580

aagatcctat tatcatgtta atcaaaataa tagagggaaa tggtaaagag ctttatgtat   2640

ttattaaaaa aagaaaaatg t                                             2661


<210>  2431
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  2431

Met Ala Leu Lys Asp Thr Gly Ser Gly Gly Ser Thr Ile Leu Pro Ile 
1               5                   10                  15


Ser Glu Met Val Ser Ser Ser Ser Ser Pro Gly Ala Ser Ala Ala Ala 
            20                  25                  30


Ala Pro Gly Pro Cys Ala Pro Ser Pro Phe Pro Glu Val Val Glu Leu 
        35                  40                  45


Asn Val Gly Gly Gln Val Tyr Val Thr Lys His Ser Thr Leu Leu Ser 
    50                  55                  60


Val Pro Asp Ser Thr Leu Ala Ser Met Phe Ser Pro Ser Ser Pro Arg 
65                  70                  75                  80


Gly Gly Ala Arg Arg Arg Gly Glu Leu Pro Arg Asp Ser Arg Ala Arg 
                85                  90                  95


Phe Phe Ile Asp Arg Asp Gly Phe Leu Phe Arg Tyr Val Leu Asp Tyr 
            100                 105                 110


Leu Arg Asp Lys Gln Leu Ala Leu Pro Glu His Phe Pro Glu Lys Glu 
        115                 120                 125


Arg Leu Leu Arg Glu Ala Glu Tyr Phe Gln Leu Thr Asp Leu Val Lys 
    130                 135                 140


Leu Leu Ser Pro Lys Val Thr Lys Gln Asn Ser Leu Asn Asp Glu Gly 
145                 150                 155                 160


Cys Gln Ser Asp Leu Glu Asp Asn Val Ser Gln Gly Ser Ser Asp Ala 
                165                 170                 175


Leu Leu Leu Arg Gly Ala Ala Ala Ala Val Pro Ser Gly Pro Gly Ala 
            180                 185                 190


His Gly Gly Gly Gly Gly Gly Gly Ala Gln Asp Lys Arg Ser Gly Phe 
        195                 200                 205


Leu Thr Leu Gly Tyr Arg Gly Ser Tyr Thr Thr Val Arg Asp Asn Gln 
    210                 215                 220


Ala Asp Ala Lys Phe Arg Arg Val Ala Arg Ile Met Val Cys Gly Arg 
225                 230                 235                 240


Ile Ala Leu Ala Lys Glu Val Phe Gly Asp Thr Leu Asn Glu Ser Arg 
                245                 250                 255


Asp Pro Asp Arg Gln Pro Glu Lys Tyr Thr Ser Arg Phe Tyr Leu Lys 
            260                 265                 270


Phe Thr Tyr Leu Glu Gln Ala Phe Asp Arg Leu Ser Glu Ala Gly Phe 
        275                 280                 285


His Met Val Ala Cys Asn Ser Ser Gly Thr Ala Ala Phe Val Asn Gln 
    290                 295                 300


Tyr Arg Asp Asp Lys Ile Trp Ser Ser Tyr Thr Glu Tyr Ile Phe Phe 
305                 310                 315                 320


Arg Pro Pro Gln Lys Ile Val Ser Pro Lys Gln Glu His Glu Asp Arg 
                325                 330                 335


Lys His Asp Lys Val Thr Asp Lys Gly Ser Glu Ser Gly Thr Ser Cys 
            340                 345                 350


Asn Glu Leu Ser Thr Ser Ser Cys Asp Ser His Ser Glu Ala Ser Thr 
        355                 360                 365


Pro Gln Asp Asn Pro Ser Ser Ala Gln Gln Ala Thr Ala His Gln Pro 
    370                 375                 380


Asn Thr Leu Thr Leu Asp Arg Pro Ser Lys Lys Ala Pro Val Gln Trp 
385                 390                 395                 400


Ile Pro Pro Pro Asp Lys Arg Arg Asn Ser Glu Leu Phe Gln Thr Leu 
                405                 410                 415


Ile Ser Lys Ser Arg Glu Thr Asn Leu Ser Lys Lys Lys Val Cys Glu 
            420                 425                 430


Lys Leu Ser Val Glu Glu Glu Met Lys Lys Cys Ile Gln Asp Phe Lys 
        435                 440                 445


Lys Ile His Ile Pro Asp Tyr Phe Pro Glu Arg Lys Arg Gln Trp Gln 
    450                 455                 460


Ser Glu Leu Leu Gln Lys Tyr Gly Leu 
465                 470


<210>  2432
<211>  561
<212>  DNA
<213>  Homo sapiens

<400>  2432
aaaaggttca ggggtgcctt gcatctcaga agcaaccgga aaacccaatg cagaaggcaa     60

attgtttagc taaagatgtg aggtgaaact gttgtccatt taagtcagtg tacaccactg    120

tggattagga gccccagctt gaggttctgg ctggacaagc aggtagatta tcattaagac    180

atgggttcac aacaaggtga catcacagct aaaggatcct tctactcagg aagatcaaac    240

ctacatgaat gaaaataatg tcatgcaata ttggaggttc atcacaaaca gagaagaaat    300

taatagctga gaaaacctgg actggaacat tagtgcttgg aactgtcaaa cctgcatctt    360

taaagaactg ggcccttctt cagagagaaa agaaaacatc aaagctttac tgaacaatgt    420

taatggatga cttgtttctc ttcatgttac tgcaaagaaa gataaatcat gaaccataaa    480

tctgtgtttc ttttttcttt catctgtatt caaccttagt tcactgacat actctaagat    540

ttcttgtcat taaaagcttt t                                              561


<210>  2433
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  2433

Met Lys Ile Met Ser Cys Asn Ile Gly Gly Ser Ser Gln Thr Glu Lys 
1               5                   10                  15


Lys Leu Ile Ala Glu Lys Thr Trp Thr Gly Thr Leu Val Leu Gly Thr 
            20                  25                  30


Val Lys Pro Ala Ser Leu Lys Asn Trp Ala Leu Leu Gln Arg Glu Lys 
        35                  40                  45


Lys Thr Ser Lys Leu Tyr 
    50


<210>  2434
<211>  6785
<212>  DNA
<213>  Homo sapiens

<400>  2434
attggctccc tggctcaatt ctgctgggag tcgcatccta cctgtttggg aggtgcactg     60

cctttccaca ctctcccttc tgtactcagc cagctgctgc tgaggtggga ggaaaagtcc    120

tggctgggag aattgagcta gtgcagcaca cgtaaaaaag cgattccgat gggtcctttg    180

aaagcttttc tcttctcccc ttttcttctg cggagtcaaa gtagaggggt gaggttggtc    240

ttcttgttac tgaccctgca tttgggaaac tgtgttgata aggcagatga tgaagatgat    300

gaggatttaa cggtgaacaa aacctgggtc ttggccccaa aaattcatga aggagatatc    360

acacaaattc tgaattcatt gcttcaaggc tatgacaata aacttcgtcc agatatagga    420

gtgaggccca cagtaattga aactgatgtt tatgtaaaca gcattggacc agttgatcca    480

attaatatgg aatatacaat agatataatt tttgcccaaa cctggtttga cagtcgttta    540

aaattcaata gtaccatgaa agtgcttatg cttaacagta atatggttgg aaaaatttgg    600

attcctgaca ctttcttcag aaactcaaga aaatctgatg ctcactggat aacaactcct    660

aatcgtctgc ttcgaatttg gaatgatgga cgagttctgt atactctaag attgacaatt    720

aatgcagaat gttatcttca gcttcataac tttcccatgg atgaacattc ctgtccactg    780

gaattttcaa gctatggata ccctaaaaat gaaattgagt ataagtggaa aaagccctcc    840

gtagaagtgg ctgatcctaa atactggaga ttatatcagt ttgcatttgt agggttacgg    900

aactcaactg aaatcactca cacgatctct ggggattatg ttatcatgac aatttttttt    960

gacctgagca gaagaatggg atatttcact attcagacct acattccatg cattctgaca   1020

gttgttcttt cttgggtgtc tttttggatc aataaagatg cagtgcctgc aagaacatcg   1080

ttgggtatca ctacagttct gactatgaca accctgagta caattgccag gaagtcttta   1140

cctaaggttt cttatgtgac tgcgatggat ctctttgttt ctgtttgttt catttttgtt   1200

tttgcagcct tgatggaata tggaaccttg cattatttta ccagcaacca aaaaggaaag   1260

actgctacta aagacagaaa gctaaaaaat aaagcctcga tgactcctgg tctccatcct   1320

ggatccactc tgattccaat gaataatatt tctgtgccgc aagaagatga ttatgggtat   1380

cagtgtttgg agggcaaaga ttgtgccagc ttcttctgtt gctttgaaga ctgcagaaca   1440

ggatcttgga gggaaggaag gatacacata cgcattgcca aaattgactc ttattctaga   1500

atatttttcc caaccgcttt tgccctgttc aacttggttt attgggttgg ctatctttac   1560

ttataaaatc tacttcataa gcaaaaatca aaagaagtct gactaaattc agtagaatct   1620

tttgtgcttc agtaacttga agtttaaatt taaaatgcag agagaccaat ggttaaaatg   1680

tgaatagtat tgtaactatt ttaaggcctt cagaagtaaa taaagtagca gctttcaggc   1740

taatttacgt gaaactgatt agttgcaaaa tccagtaggt taaaatactc acatattttt   1800

acttaaattt tctttaattt acttatatgt tattataatt ttgaattttt aagttctatg   1860

attcatgttt taaagatgga ataattttaa tacatatttt gtttaaatat aatctataat   1920

tgttttgtaa tgtaagacta attactaata tttatgtagc aacttttgtg ccagaaaaaa   1980

gactgttaat ttgttttttc ttgcttttca tttgattacc ctgcttgaaa tacagttagt   2040

tgataacata aagccatagt tttcttggat tttcttccaa gatattgtat tcccaagaag   2100

aaattgattt atttttaaac tatcagttac tgaagactta tgaaaaggtc aatttttacc   2160

tgtcttttaa tccagtccat tttctgacac aatattaaac agaacgccag ttgcatttac   2220

tttggtgatt tgcaaacttg gaatgaagcc accagtcatt ttttaagaat gcaagatgaa   2280

aaaatcaggt aaaatctaac cattttattc tctgcttcat agcatttata atgtatgatg   2340

aggttaacac tgaaatatta aaatctgcaa atgcacatta atgcaaatta aatgcagaga   2400

gaaatgatta tttttttctt tatgttttat gaaagtgttg cagtccctaa aataaaaata   2460

ttgaggaaca ttgcttgtat ttactcacgt ggttaaaaaa ttattacctg gcaaactgag   2520

ttgccggtca tattgaggac aaaatcttaa atatgtgcta ttagcattgt ttttagacta   2580

gtaatatgca gaaaacagtt ttaggcctgc gttacatatt gcctcttcca gctccaaagt   2640

tttggaccct gtcagttttg caactacatt atacattatt ataatattct tttttttttc   2700

tagaaactgg gggcagcctc aaaatcatgt taaagaggga gttttgttag aggcatcttt   2760

aatgaacatg aatgtgagtg ctctctaaat tcttagcatc tcactggatg taaaatctat   2820

cagttaatag ttttaaaaat gtctcttttg ttaagaataa atttaggctt caatcattat   2880

aatcctgtaa gtagcttgac ataccaattg tttataagat tcatcacata aatttctgga   2940

gaaccaccag gtttagcttg gaaataacct ttaaagattg tttctgttgc caagaccaat   3000

gaccatgatg aagagtttta tgatcacagc ctatcttact taaggtttga gaggaaacct   3060

gtcacctctg caattgttac tctagttttt aatgttataa ttccgctgcg tggttagtga   3120

atgtctggca tgattataca cgtgtattgg aaatatctag ttttttaaat ttttaattaa   3180

tttatttata atttactgtg tgttcccagc taactctatt ttttttttca cttgctcata   3240

aacttctgga aaaaaataag catgaatcaa atggtaatgc ccaatatcca ccgacactgc   3300

ttttcttgaa tgaacagcca aactaaactt tggccatcta tatattcatt tacagattat   3360

tcatacattc attttaataa cattgagtac tgatggatgt tttgaaagtg agcattcatt   3420

taaggataaa taaaaaataa agtagtaata aagaataaaa tactttacta aaatattgta   3480

tggctatttt catgtttgaa gctatagctt actatcatga gacagttttg attttgggac   3540

tctttcaagt gtatctgagc atgactgtat tttaaaatac ttaaaagtgc ttgatataaa   3600

tagcttttcc ttctgaacca cgttctatgt aaaagaaaaa aaatagcttt gattttctca   3660

ctggtgtttc attaacttgg ttttaaatgt tgacaatatt tacaagtgga aataaaattt   3720

gtaaatatat gaaagatgcc tttccttgta tataccatca agcaagcact ttgttttcaa   3780

agcaagtggt attttgatca gttttattta aatgtgtgat cagaaagaat ggcgtacaaa   3840

tcttattatt tctaaaaata agaataaaaa ggtaaaacta catttagact tctttctcaa   3900

gaaatcaaat acagcttttt ttcaaagctg attcagttca tttcctgttc ctctattcca   3960

agtataagtt tcaccacctt gagaaataat ttttttaaaa aatcttcctc tttctctggg   4020

gagttatata ataatttatt gaatttattg gaacttgatt ttcctggatg ctttcaatgt   4080

ttttaatgct aacatagacc ccaaaattag atataaagaa ttgggaagga tacctggagc   4140

acaaggaata agatcatttg taaaaatgtt tgtttatata gacctatcct ctaaatatgt   4200

gacaaggatc tagaaattct gagaggggaa aatgtgattt tggatttaca atgacagggt   4260

aatattttat ttatcttcga attccatgga caaaattagg ctcacttaaa ttaatttttg   4320

taaacccaag taagttctaa aaaaaagtaa aaaatacata gaatacttga gaatttagca   4380

gggacaggga aaaatttccc agtaagtctg aagtcttgat gtaagtggga attagataac   4440

taattggagg cattttattt taagttaaag acagatttct ttaataagtt tttaaaattg   4500

atcaacttta aattaagcac agtaaatgtg tataaatatg aaggcaatca taaggatttt   4560

ttcacttgtg tttccatatt ctggcattag tatatcatca taaaatagac aatgtttttg   4620

tctcaagaac aagaataaaa ttgaaatctg cattcatgcc aattcagcat aaaaaagaat   4680

aggctacagt tctctcacac caagggcccc atagttataa atgtgaaatt atattccagg   4740

tcaaaatttg tgaaaaatac acaaaacact ttgattttac aagagaggag ctttaaataa   4800

gatgatttta gtagattgaa ataaataacc agtatttaag taaatgtata acgaatgaat   4860

aaatacatgc ataatatttt caaagttcta taccagtacc tatttttact cttacaaaat   4920

ttcctgtaaa aaaatactac atttgaaatt atttcattgg ttttagaact ggcattgaag   4980

gtacccagta gactcttaag cctttactgc ttgtctcact agaaacattt atttctgacc   5040

taccaagttt tcttcacatc atcaaattta ttcagcttct cagtgctgta ccgtatgatg   5100

gcaagacata cttggtattt ccatttttgt tggtcattct ttattgcttt ttactgctag   5160

gaaggtcttg ccaggcttct atacagttac aaaaaccatt accaaacttt atcaaggact   5220

ttccaaatgg agttttcaaa tactattgac cacattgctc tagttaatgt aaggtcagct   5280

ctgacttttt gtgtttgcat ttcggaagtg aggtaacctc attcaaatat atatgcagca   5340

ctttctgtgt acaaagtact gttctaaata caaaagggaa tataaagatg actttcaagg   5400

aacatataat gtagtcagaa agatgagagg attagttata caatttaagg aagggaggat   5460

aactttggga aggttttgtg gaggatatgt gtttagagat gcgagctggg gattcaacag   5520

gtaagaggga gagagatcac aatttccaac tgggtaaaca gcttgaaaaa agaaacagaa   5580

gcctgggcac aaatgaaaat tccatattaa ttggaagtta agattcatat agagacaatg   5640

aaaggttagg ttagaacaat aaactgagaa gtacgaatgt ggacttcagg aggctagggg   5700

aaattacgaa gtcataaaaa gttcacagag atacttgagt acaaaagata cattattaaa   5760

atttctgcag aagtttcatc ttatttgtgt gtgatggttt ggaatataac aagccagtta   5820

ggcgtataag cttatagtgg ctaatatgag gatgaaatcc gtactcttgt gacacaagtc   5880

ttcagcggag atgggggatg ataggcccaa atagaaagaa aagtggcaga cattaagctt   5940

tgactaacag acaacataac tgagagacat ggtgtgttgg gtggaaggga tcctgtagta   6000

gatacttgct tgcatgtaga tgggtacaaa gacaccataa ggaaattctg aatgtaatac   6060

aaaggcttat ttttcctgtt gatttatctt tttcacacat aaaagatgaa gaaaaaaata   6120

atctgaaatg taaatcctaa agtgatctgt ctagattctt attttttgaa aaatgttcct   6180

cactaaaaga gttttctatt caaataacca tttccagttt tctaactgag acatacatac   6240

atatatatat gtataaaatt atatatatat ttggacaaag agaataagag aattgcaggt   6300

agaaatagtc tactgtgtgt agacaaatcc agaaagttga tttctgttcc tcaaacaatt   6360

tctgaaatat ttatgtcaga ataaataaaa gaattgttat tgttggacaa tgaaacatac   6420

ctggaccctt tgagtgtgtg aatagtaaag gctgtgataa ctgaaatgca gctaagcaaa   6480

aagggctaat tagaagactt ttgagacatg atttacctaa atggaaatag tttggttttc   6540

aatccttcac tgtaataaca attatttgca tctattaagt gtttgtagtc actttgtata   6600

ataaagtttt atggcttgtg attataatgg cttctgttat tctgctactg cctcattgtt   6660

ttgaggaaca tttgtaattt tgtggcaaag gtgtctcaat ttttcagtgt tctttactct   6720

catgatcctt agaacaaaaa aaataccagt aacttgttat aaataaagag tcacattctc   6780

ttaaa                                                               6785


<210>  2435
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  2435

Met Gly Pro Leu Lys Ala Phe Leu Phe Ser Pro Phe Leu Leu Arg Ser 
1               5                   10                  15


Gln Ser Arg Gly Val Arg Leu Val Phe Leu Leu Leu Thr Leu His Leu 
            20                  25                  30


Gly Asn Cys Val Asp Lys Ala Asp Asp Glu Asp Asp Glu Asp Leu Thr 
        35                  40                  45


Val Asn Lys Thr Trp Val Leu Ala Pro Lys Ile His Glu Gly Asp Ile 
    50                  55                  60


Thr Gln Ile Leu Asn Ser Leu Leu Gln Gly Tyr Asp Asn Lys Leu Arg 
65                  70                  75                  80


Pro Asp Ile Gly Val Arg Pro Thr Val Ile Glu Thr Asp Val Tyr Val 
                85                  90                  95


Asn Ser Ile Gly Pro Val Asp Pro Ile Asn Met Glu Tyr Thr Ile Asp 
            100                 105                 110


Ile Ile Phe Ala Gln Thr Trp Phe Asp Ser Arg Leu Lys Phe Asn Ser 
        115                 120                 125


Thr Met Lys Val Leu Met Leu Asn Ser Asn Met Val Gly Lys Ile Trp 
    130                 135                 140


Ile Pro Asp Thr Phe Phe Arg Asn Ser Arg Lys Ser Asp Ala His Trp 
145                 150                 155                 160


Ile Thr Thr Pro Asn Arg Leu Leu Arg Ile Trp Asn Asp Gly Arg Val 
                165                 170                 175


Leu Tyr Thr Leu Arg Leu Thr Ile Asn Ala Glu Cys Tyr Leu Gln Leu 
            180                 185                 190


His Asn Phe Pro Met Asp Glu His Ser Cys Pro Leu Glu Phe Ser Ser 
        195                 200                 205


Tyr Gly Tyr Pro Lys Asn Glu Ile Glu Tyr Lys Trp Lys Lys Pro Ser 
    210                 215                 220


Val Glu Val Ala Asp Pro Lys Tyr Trp Arg Leu Tyr Gln Phe Ala Phe 
225                 230                 235                 240


Val Gly Leu Arg Asn Ser Thr Glu Ile Thr His Thr Ile Ser Gly Asp 
                245                 250                 255


Tyr Val Ile Met Thr Ile Phe Phe Asp Leu Ser Arg Arg Met Gly Tyr 
            260                 265                 270


Phe Thr Ile Gln Thr Tyr Ile Pro Cys Ile Leu Thr Val Val Leu Ser 
        275                 280                 285


Trp Val Ser Phe Trp Ile Asn Lys Asp Ala Val Pro Ala Arg Thr Ser 
    290                 295                 300


Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Leu Ser Thr Ile Ala 
305                 310                 315                 320


Arg Lys Ser Leu Pro Lys Val Ser Tyr Val Thr Ala Met Asp Leu Phe 
                325                 330                 335


Val Ser Val Cys Phe Ile Phe Val Phe Ala Ala Leu Met Glu Tyr Gly 
            340                 345                 350


Thr Leu His Tyr Phe Thr Ser Asn Gln Lys Gly Lys Thr Ala Thr Lys 
        355                 360                 365


Asp Arg Lys Leu Lys Asn Lys Ala Ser Met Thr Pro Gly Leu His Pro 
    370                 375                 380


Gly Ser Thr Leu Ile Pro Met Asn Asn Ile Ser Val Pro Gln Glu Asp 
385                 390                 395                 400


Asp Tyr Gly Tyr Gln Cys Leu Glu Gly Lys Asp Cys Ala Ser Phe Phe 
                405                 410                 415


Cys Cys Phe Glu Asp Cys Arg Thr Gly Ser Trp Arg Glu Gly Arg Ile 
            420                 425                 430


His Ile Arg Ile Ala Lys Ile Asp Ser Tyr Ser Arg Ile Phe Phe Pro 
        435                 440                 445


Thr Ala Phe Ala Leu Phe Asn Leu Val Tyr Trp Val Gly Tyr Leu Tyr 
    450                 455                 460


Leu 
465


<210>  2436
<211>  1456
<212>  DNA
<213>  Homo sapiens

<400>  2436
ggcggtgatg aagacaaaat tgaacatcta caacatgcag ttcctgcttt ttgttttctt     60

ggtgtgggac cctgccaggt tggtgctggc taacatccaa gaagatgagg ctaaaaataa    120

cattaccatc tttacgagaa ttcttgacag acttctggat ggttacgata atcggcttag    180

accaggactg ggagaaaaaa gaaaaggctt ccgttatgat acagaacaac gcttatgcag    240

tggctgttgc caattatgcc ccgaatcttt caaaagatcc agttctctcc accatctcca    300

agagtgcaac cacgccagaa cccaacaaga agccagaaaa caagccagct gaagcaaaga    360

aaactttcaa cagtgttagc aaaattgaca gaatgtccag aatagttttt ccagttttgt    420

ttggtacctt taatttagtt tactgggcta catatttaaa cagagaacct gtattagggg    480

tcagtccttg aattgagacc catgttatct ttgggatgta tagcaacatt aaatttggtt    540

tgttttgcta tgtacagtct gactaataac tgctaatttg tgatccaaca tgtacagtat    600

gtatatagtg acatagctta ccagtagacc tttaatggag acatgcattt gctaactcat    660

ggaactgcag acagaaagca ctccatgcga aaacagccat tgcctttttt aaagatttac    720

cctaggacct gatttaaagt gaatttcaag tgacctgatt aatttcctat tcttccaaat    780

gagatgaaaa tggggatcct gtacaaccct ttgtggaccc ttttggttta gctcttaagt    840

aggggtattt tctactgttg cttaattatg atggaagata acattgtcat tcctagatga    900

atcctttgaa gtaacaaaca ttgtatctga catcagctct gttcatgagt gctcagagtc    960

cctgctaatg taattggaag cttggtacac ataagaaaaa ctagagattt gaaatcagct   1020

atgaattact ctatatagta tctatagcca tgtacatatt acagcatgac aagctcaaat   1080

aattatgagt cagcccgaaa ggatgttaat tatgcctacg atgtaataac tattggaatg   1140

tcatggtcat tacattttta gcttcagagt ttatttgaaa gtaataattg aaatcctaca   1200

atttatttta atcattggaa actaccttaa ttaaaaaaaa agaaaagaaa tgtgtcttaa   1260

catttccagg tatgtgttgt attgaaattg atcagctaaa ttttacgggt gctggagact   1320

ggaaaaagca tccagtttgg ttgctgtgga gcaacatgca tattggatta gaaaattgtg   1380

ccaaaaactc ccactgatga gaattcatag gtgccccaca ctatgacaaa cacttatatg   1440

attctcctct ttcctg                                                   1456


<210>  2437
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  2437

Met Arg Leu Lys Ile Thr Leu Pro Ser Leu Arg Glu Phe Leu Thr Asp 
1               5                   10                  15


Phe Trp Met Val Thr Ile Ile Gly Leu Asp Gln Asp Trp Glu Lys Lys 
            20                  25                  30


Glu Lys Ala Ser Val Met Ile Gln Asn Asn Ala Tyr Ala Val Ala Val 
        35                  40                  45


Ala Asn Tyr Ala Pro Asn Leu Ser Lys Asp Pro Val Leu Ser Thr Ile 
    50                  55                  60


Ser Lys Ser Ala Thr Thr Pro Glu Pro Asn Lys Lys Pro Glu Asn Lys 
65                  70                  75                  80


Pro Ala Glu Ala Lys Lys Thr Phe Asn Ser Val Ser Lys Ile Asp Arg 
                85                  90                  95


Met Ser Arg Ile Val Phe Pro Val Leu Phe Gly Thr Phe Asn Leu Val 
            100                 105                 110


Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Val Leu Gly Val Ser Pro 
        115                 120                 125


<210>  2438
<211>  2429
<212>  DNA
<213>  Homo sapiens

<400>  2438
ggcggtgatg aagacaaaat tgaacatcta caacatgcag ttcctgcttt ttgttttctt     60

ggtgtgggac cctgccagag accaatcagg aagaactagg ctctaaggat ctctgcagct    120

gtgtatgtgt tgctgatgct ttcagagccc acctccacct cctggctaca tggagcctgg    180

cacatagcca gtggagtttc cctgatgctt atattgcact tggccattgg gtggaggtat    240

acccaaagtt ggtgctggct aacatccaag aagatgaggc taaaaataac attaccatct    300

ttacgagaat tcttgacaga cttctggatg gttacgataa tcggcttaga ccaggactgg    360

gaggaatata caattgatgt tttctttcga caaaaatgga aagatgaacg tttaaaattt    420

aaaggtccta tgaatatcct tcgactaaac aatttaatgg ctagcaaaat ctggactcca    480

gatacctttt ttcacaatgg gaaaaaatca gtagctcata atatgacaat gccaaataag    540

ttgcttcgaa ttcaggatga tgggactctg ctgtatacca tgaggcttac agttcaagct    600

gaatgcccaa tgcacttgga ggatttccca atggatgctc attcatgtcc tctgaaattt    660

ggcagctatg catatacaac ttcagaggtc acttatattt ggacttacaa tgcatctgat    720

tcagtacagg ttgctcctga tggctctagg ttaaatcaat atgacctgct gggccaatca    780

atcggaaagg agacaattaa atccagtaca ggtgaatata ctgtaatgac agctcatttc    840

cacctgaaaa gaaaaattgg gtattttgtg attcaaacct atctgccttg catcatgact    900

gtcattctct cccaagtttc attctggctt aacagagaat ctgtgcctgc aagaactgtg    960

tttggagtaa caactgtcct aacaatgaca actctaagca tcagtgctcg gaattctctc   1020

cccaaagtgg cttatgcaac tgccatggac tggtttattg ctgtttgtta tgcatttgtg   1080

ttctctgccc taattgaatt tgcaactgtt aattacttca ccaaaagagg atgggcttgg   1140

gatgggaaga gtgtagtaaa tgacaagaaa aaagaaaagg cttccgttat gatacagaac   1200

aacgcttatg cagtggctgt tgccaattat gccccgaatc tttcaaaaga tccagttctc   1260

tccaccatct ccaagagtgc aaccacgcca gaacccaaca agaagccaga aaacaagcca   1320

gctgaagcaa agaaaacttt caacagtgtt agcaaaattg acagaatgtc cagaatagtt   1380

tttccagttt tgtttggtac ctttaattta gtttactggg ctacatattt aaacagagaa   1440

cctgtattag gggtcagtcc ttgaattgag acccatgtta tctttgggat gtatagcaac   1500

attaaatttg gtttgttttg ctatgtacag tctgactaat aactgctaat ttgtgatcca   1560

acatgtacag tatgtatata gtgacatagc ttaccagtag acctttaatg gagacatgca   1620

tttgctaact catggaactg cagacagaaa gcactccatg cgaaaacagc cattgccttt   1680

tttaaagatt taccctagga cctgatttaa agtgaatttc aagtgacctg attaatttcc   1740

tattcttcca aatgagatga aaatggggat cctgtacaac cctttgtgga cccttttggt   1800

ttagctctta agtaggggta ttttctactg ttgcttaatt atgatggaag ataacattgt   1860

cattcctaga tgaatccttt gaagtaacaa acattgtatc tgacatcagc tctgttcatg   1920

agtgctcaga gtccctgcta atgtaattgg aagcttggta cacataagaa aaactagaga   1980

tttgaaatca gctatgaatt actctatata gtatctatag ccatgtacat attacagcat   2040

gacaagctca aataattatg agtcagcccg aaaggatgtt aattatgcct acgatgtaat   2100

aactattgga atgtcatggt cattacattt ttagcttcag agtttatttg aaagtaataa   2160

ttgaaatcct acaatttatt ttaatcattg gaaactacct taattaaaaa aaaagaaaag   2220

aaatgtgtct taacatttcc aggtatgtgt tgtattgaaa ttgatcagct aaattttacg   2280

ggtgctggag actggaaaaa gcatccagtt tggttgctgt ggagcaacat gcatattgga   2340

ttagaaaatt gtgccaaaaa ctcccactga tgagaattca taggtgcccc acactatgac   2400

aaacacttat atgattctcc tctttcctg                                     2429


<210>  2439
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  2439

Met Leu Ser Glu Pro Thr Ser Thr Ser Trp Leu His Gly Ala Trp His 
1               5                   10                  15


Ile Ala Ser Gly Val Ser Leu Met Leu Ile Leu His Leu Ala Ile Gly 
            20                  25                  30


Trp Arg Tyr Thr Gln Ser Trp Cys Trp Leu Thr Ser Lys Lys Met Arg 
        35                  40                  45


Leu Lys Ile Thr Leu Pro Ser Leu Arg Glu Phe Leu Thr Asp Phe Trp 
    50                  55                  60


Met Val Thr Ile Ile Gly Leu Asp Gln Asp Trp Glu Glu Tyr Thr Ile 
65                  70                  75                  80


Asp Val Phe Phe Arg Gln Lys Trp Lys Asp Glu Arg Leu Lys Phe Lys 
                85                  90                  95


Gly Pro Met Asn Ile Leu Arg Leu Asn Asn Leu Met Ala Ser Lys Ile 
            100                 105                 110


Trp Thr Pro Asp Thr Phe Phe His Asn Gly Lys Lys Ser Val Ala His 
        115                 120                 125


Asn Met Thr Met Pro Asn Lys Leu Leu Arg Ile Gln Asp Asp Gly Thr 
    130                 135                 140


Leu Leu Tyr Thr Met Arg Leu Thr Val Gln Ala Glu Cys Pro Met His 
145                 150                 155                 160


Leu Glu Asp Phe Pro Met Asp Ala His Ser Cys Pro Leu Lys Phe Gly 
                165                 170                 175


Ser Tyr Ala Tyr Thr Thr Ser Glu Val Thr Tyr Ile Trp Thr Tyr Asn 
            180                 185                 190


Ala Ser Asp Ser Val Gln Val Ala Pro Asp Gly Ser Arg Leu Asn Gln 
        195                 200                 205


Tyr Asp Leu Leu Gly Gln Ser Ile Gly Lys Glu Thr Ile Lys Ser Ser 
    210                 215                 220


Thr Gly Glu Tyr Thr Val Met Thr Ala His Phe His Leu Lys Arg Lys 
225                 230                 235                 240


Ile Gly Tyr Phe Val Ile Gln Thr Tyr Leu Pro Cys Ile Met Thr Val 
                245                 250                 255


Ile Leu Ser Gln Val Ser Phe Trp Leu Asn Arg Glu Ser Val Pro Ala 
            260                 265                 270


Arg Thr Val Phe Gly Val Thr Thr Val Leu Thr Met Thr Thr Leu Ser 
        275                 280                 285


Ile Ser Ala Arg Asn Ser Leu Pro Lys Val Ala Tyr Ala Thr Ala Met 
    290                 295                 300


Asp Trp Phe Ile Ala Val Cys Tyr Ala Phe Val Phe Ser Ala Leu Ile 
305                 310                 315                 320


Glu Phe Ala Thr Val Asn Tyr Phe Thr Lys Arg Gly Trp Ala Trp Asp 
                325                 330                 335


Gly Lys Ser Val Val Asn Asp Lys Lys Lys Glu Lys Ala Ser Val Met 
            340                 345                 350


Ile Gln Asn Asn Ala Tyr Ala Val Ala Val Ala Asn Tyr Ala Pro Asn 
        355                 360                 365


Leu Ser Lys Asp Pro Val Leu Ser Thr Ile Ser Lys Ser Ala Thr Thr 
    370                 375                 380


Pro Glu Pro Asn Lys Lys Pro Glu Asn Lys Pro Ala Glu Ala Lys Lys 
385                 390                 395                 400


Thr Phe Asn Ser Val Ser Lys Ile Asp Arg Met Ser Arg Ile Val Phe 
                405                 410                 415


Pro Val Leu Phe Gly Thr Phe Asn Leu Val Tyr Trp Ala Thr Tyr Leu 
            420                 425                 430


Asn Arg Glu Pro Val Leu Gly Val Ser Pro 
        435                 440


<210>  2440
<211>  2260
<212>  DNA
<213>  Homo sapiens

<400>  2440
ggcggtgatg aagacaaaat tgaacatcta caacatgcag ttcctgcttt ttgttttctt     60

ggtgtgggac cctgccaggt tggtgctggc taacatccaa gaagatgagg ctaaaaataa    120

cattaccatc tttacgagaa ttcttgacag acttctggat ggttacgata atcggcttag    180

accaggactg ggaggaatat acaattgatg ttttctttcg acaaaaatgg aaagatgaac    240

gtttaaaatt taaaggtcct atgaatatcc ttcgactaaa caatttaatg gctagcaaaa    300

tctggactcc agataccttt tttcacaatg ggaaaaaatc agtagctcat aatatgacaa    360

tgccaaataa gttgcttcga attcaggatg atgggactct gctgtatacc atgaggctta    420

cagttcaagc tgaatgccca atgcacttgg aggatttccc aatggatgct cattcatgtc    480

ctctgaaatt tggcagctat gcatatacaa cttcagaggt cacttatatt tggacttaca    540

atgcatctga ttcagtacag gttgctcctg atggctctag gttaaatcaa tatgacctgc    600

tgggccaatc aatcggaaag gagacaatta aatccagtac aggtgaatat actgtaatga    660

cagctcattt ccacctgaaa agaaaaattg ggtattttgt gattcaaacc tatctgcctt    720

gcatcatgac tgtcattctc tcccaagttt cattctggct taacagagaa tctgtgcctg    780

caagaactgt gtttggagta acaactgtcc taacaatgac aactctaagc atcagtgctc    840

ggaattctct ccccaaagtg gcttatgcaa ctgccatgga ctggtttatt gctgtttgtt    900

atgcatttgt gttctctgcc ctaattgaat ttgcaactgt taattacttc accaaaagag    960

gatgggcttg ggatgggaag agtgtagtaa atgacaagaa aaaagaaaag gcttccgtta   1020

tgatacagaa caacgcttat gcagtggctg ttgccaatta tgccccgaat ctttcaaaag   1080

atccagttct ctccaccatc tccaagagtg caaccacgcc agaacccaac aagaagccag   1140

aaaacaagcc agctgaagca aagaaaactt tcaacagtgt tagcaaaatt gacagaatgt   1200

ccagaatagt ttttccagtt ttgtttggta cctttaattt agtttactgg gctacatatt   1260

taaacagaga acctgtatta ggggtcagtc cttgaattga gacccatgtt atctttggga   1320

tgtatagcaa cattaaattt ggtttgtttt gctatgtaca gtctgactaa taactgctaa   1380

tttgtgatcc aacatgtaca gtatgtatat agtgacatag cttaccagta gacctttaat   1440

ggagacatgc atttgctaac tcatggaact gcagacagaa agcactccat gcgaaaacag   1500

ccattgcctt ttttaaagat ttaccctagg acctgattta aagtgaattt caagtgacct   1560

gattaatttc ctattcttcc aaatgagatg aaaatgggga tcctgtacaa ccctttgtgg   1620

acccttttgg tttagctctt aagtaggggt attttctact gttgcttaat tatgatggaa   1680

gataacattg tcattcctag atgaatcctt tgaagtaaca aacattgtat ctgacatcag   1740

ctctgttcat gagtgctcag agtccctgct aatgtaattg gaagcttggt acacataaga   1800

aaaactagag atttgaaatc agctatgaat tactctatat agtatctata gccatgtaca   1860

tattacagca tgacaagctc aaataattat gagtcagccc gaaaggatgt taattatgcc   1920

tacgatgtaa taactattgg aatgtcatgg tcattacatt tttagcttca gagtttattt   1980

gaaagtaata attgaaatcc tacaatttat tttaatcatt ggaaactacc ttaattaaaa   2040

aaaaagaaaa gaaatgtgtc ttaacatttc caggtatgtg ttgtattgaa attgatcagc   2100

taaattttac gggtgctgga gactggaaaa agcatccagt ttggttgctg tggagcaaca   2160

tgcatattgg attagaaaat tgtgccaaaa actcccactg atgagaattc ataggtgccc   2220

cacactatga caaacactta tatgattctc ctctttcctg                         2260


<210>  2441
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  2441

Met Arg Leu Lys Ile Thr Leu Pro Ser Leu Arg Glu Phe Leu Thr Asp 
1               5                   10                  15


Phe Trp Met Val Thr Ile Ile Gly Leu Asp Gln Asp Trp Glu Glu Tyr 
            20                  25                  30


Thr Ile Asp Val Phe Phe Arg Gln Lys Trp Lys Asp Glu Arg Leu Lys 
        35                  40                  45


Phe Lys Gly Pro Met Asn Ile Leu Arg Leu Asn Asn Leu Met Ala Ser 
    50                  55                  60


Lys Ile Trp Thr Pro Asp Thr Phe Phe His Asn Gly Lys Lys Ser Val 
65                  70                  75                  80


Ala His Asn Met Thr Met Pro Asn Lys Leu Leu Arg Ile Gln Asp Asp 
                85                  90                  95


Gly Thr Leu Leu Tyr Thr Met Arg Leu Thr Val Gln Ala Glu Cys Pro 
            100                 105                 110


Met His Leu Glu Asp Phe Pro Met Asp Ala His Ser Cys Pro Leu Lys 
        115                 120                 125


Phe Gly Ser Tyr Ala Tyr Thr Thr Ser Glu Val Thr Tyr Ile Trp Thr 
    130                 135                 140


Tyr Asn Ala Ser Asp Ser Val Gln Val Ala Pro Asp Gly Ser Arg Leu 
145                 150                 155                 160


Asn Gln Tyr Asp Leu Leu Gly Gln Ser Ile Gly Lys Glu Thr Ile Lys 
                165                 170                 175


Ser Ser Thr Gly Glu Tyr Thr Val Met Thr Ala His Phe His Leu Lys 
            180                 185                 190


Arg Lys Ile Gly Tyr Phe Val Ile Gln Thr Tyr Leu Pro Cys Ile Met 
        195                 200                 205


Thr Val Ile Leu Ser Gln Val Ser Phe Trp Leu Asn Arg Glu Ser Val 
    210                 215                 220


Pro Ala Arg Thr Val Phe Gly Val Thr Thr Val Leu Thr Met Thr Thr 
225                 230                 235                 240


Leu Ser Ile Ser Ala Arg Asn Ser Leu Pro Lys Val Ala Tyr Ala Thr 
                245                 250                 255


Ala Met Asp Trp Phe Ile Ala Val Cys Tyr Ala Phe Val Phe Ser Ala 
            260                 265                 270


Leu Ile Glu Phe Ala Thr Val Asn Tyr Phe Thr Lys Arg Gly Trp Ala 
        275                 280                 285


Trp Asp Gly Lys Ser Val Val Asn Asp Lys Lys Lys Glu Lys Ala Ser 
    290                 295                 300


Val Met Ile Gln Asn Asn Ala Tyr Ala Val Ala Val Ala Asn Tyr Ala 
305                 310                 315                 320


Pro Asn Leu Ser Lys Asp Pro Val Leu Ser Thr Ile Ser Lys Ser Ala 
                325                 330                 335


Thr Thr Pro Glu Pro Asn Lys Lys Pro Glu Asn Lys Pro Ala Glu Ala 
            340                 345                 350


Lys Lys Thr Phe Asn Ser Val Ser Lys Ile Asp Arg Met Ser Arg Ile 
        355                 360                 365


Val Phe Pro Val Leu Phe Gly Thr Phe Asn Leu Val Tyr Trp Ala Thr 
    370                 375                 380


Tyr Leu Asn Arg Glu Pro Val Leu Gly Val Ser Pro 
385                 390                 395


<210>  2442
<211>  1963
<212>  DNA
<213>  Homo sapiens

<400>  2442
ggcggtgatg aagacaaaat tgaacatcta caacatgcag ttcctgcttt ttgttttctt     60

ggtgtgggac cctgccaggt tggtgctggc taacatccaa gaagatgagg ctaaaaataa    120

cattaccatc tttacgagaa ttcttgacag acttctggat ggttacgata atcggcttag    180

accaggactg ggaggaatat acaattgatg ttttctttcg acaaaaatgg aaagatgaac    240

gtttaaaatt taaaggtcct atgaatatcc ttcgactaaa caatttaatg gctagcaaaa    300

tctggactcc agataccttt tttcacaatg ggaaaaaatc agtagctcat aatatgacaa    360

tgccaaataa gttgcttcga attcaggatg atgggactct gctgtatacc atgaggctta    420

cagttcaagc tgaatgccca atgcacttgg aggatttccc aatggatgct cattcatgtc    480

ctctgaaatt tggcagctga gtaacaactg tcctaacaat gacaactcta agcatcagtg    540

ctcggaattc tctccccaaa gtggcttatg caactgccat ggactggttt attgctgttt    600

gttatgcatt tgtgttctct gccctaattg aatttgcaac tgttaattac ttcaccaaaa    660

gaggatgggc ttgggatggg aagagtgtag taaatgacaa gaaaaaagaa aaggcttccg    720

ttatgataca gaacaacgct tatgcagtgg ctgttgccaa ttatgccccg aatctttcaa    780

aagatccagt tctctccacc atctccaaga gtgcaaccac gccagaaccc aacaagaagc    840

cagaaaacaa gccagctgaa gcaaagaaaa ctttcaacag tgttagcaaa attgacagaa    900

tgtccagaat agtttttcca gttttgtttg gtacctttaa tttagtttac tgggctacat    960

atttaaacag agaacctgta ttaggggtca gtccttgaat tgagacccat gttatctttg   1020

ggatgtatag caacattaaa tttggtttgt tttgctatgt acagtctgac taataactgc   1080

taatttgtga tccaacatgt acagtatgta tatagtgaca tagcttacca gtagaccttt   1140

aatggagaca tgcatttgct aactcatgga actgcagaca gaaagcactc catgcgaaaa   1200

cagccattgc cttttttaaa gatttaccct aggacctgat ttaaagtgaa tttcaagtga   1260

cctgattaat ttcctattct tccaaatgag atgaaaatgg ggatcctgta caaccctttg   1320

tggacccttt tggtttagct cttaagtagg ggtattttct actgttgctt aattatgatg   1380

gaagataaca ttgtcattcc tagatgaatc ctttgaagta acaaacattg tatctgacat   1440

cagctctgtt catgagtgct cagagtccct gctaatgtaa ttggaagctt ggtacacata   1500

agaaaaacta gagatttgaa atcagctatg aattactcta tatagtatct atagccatgt   1560

acatattaca gcatgacaag ctcaaataat tatgagtcag cccgaaagga tgttaattat   1620

gcctacgatg taataactat tggaatgtca tggtcattac atttttagct tcagagttta   1680

tttgaaagta ataattgaaa tcctacaatt tattttaatc attggaaact accttaatta   1740

aaaaaaaaga aaagaaatgt gtcttaacat ttccaggtat gtgttgtatt gaaattgatc   1800

agctaaattt tacgggtgct ggagactgga aaaagcatcc agtttggttg ctgtggagca   1860

acatgcatat tggattagaa aattgtgcca aaaactccca ctgatgagaa ttcataggtg   1920

ccccacacta tgacaaacac ttatatgatt ctcctctttc ctg                     1963


<210>  2443
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  2443

Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu Pro Lys Val Ala 
1               5                   10                  15


Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys Tyr Ala Phe Val 
            20                  25                  30


Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr Phe Thr Lys Arg 
        35                  40                  45


Gly Trp Ala Trp Asp Gly Lys Ser Val Val Asn Asp Lys Lys Lys Glu 
    50                  55                  60


Lys Ala Ser Val Met Ile Gln Asn Asn Ala Tyr Ala Val Ala Val Ala 
65                  70                  75                  80


Asn Tyr Ala Pro Asn Leu Ser Lys Asp Pro Val Leu Ser Thr Ile Ser 
                85                  90                  95


Lys Ser Ala Thr Thr Pro Glu Pro Asn Lys Lys Pro Glu Asn Lys Pro 
            100                 105                 110


Ala Glu Ala Lys Lys Thr Phe Asn Ser Val Ser Lys Ile Asp Arg Met 
        115                 120                 125


Ser Arg Ile Val Phe Pro Val Leu Phe Gly Thr Phe Asn Leu Val Tyr 
    130                 135                 140


Trp Ala Thr Tyr Leu Asn Arg Glu Pro Val Leu Gly Val Ser Pro 
145                 150                 155


<210>  2444
<211>  1956
<212>  DNA
<213>  Homo sapiens

<400>  2444
ggcggtgatg aagacaaaat tgaacatcta caacatgcag ttcctgcttt ttgttttctt     60

ggtgtgggac cctgccaggt tggtgctggc taacatccaa gaagatgagg ctaaaaataa    120

cattaccatc tttacgagaa ttcttgacag acttctggat ggttacgata atcggcttag    180

accaggactg ggagatgcat atacaacttc agaggtcact tatatttgga cttacaatgc    240

atctgattca gtacaggttg ctcctgatgg ctctaggtta aatcaatatg acctgctggg    300

ccaatcaatc ggaaaggaga caattaaatc cagtacaggt gaatatactg taatgacagc    360

tcatttccac ctgaaaagaa aaattgggta ttttgtgatt caaacctatc tgccttgcat    420

catgactgtc attctctccc aagtttcatt ctggcttaac agagaatctg tgcctgcaag    480

aactgtgttt ggagtaacaa ctgtcctaac aatgacaact ctaagcatca gtgctcggaa    540

ttctctcccc aaagtggctt atgcaactgc catggactgg tttattgctg tttgttatgc    600

atttgtgttc tctgccctaa ttgaatttgc aactgttaat tacttcacca aaagaggatg    660

ggcttgggat gggaagagtg tagtaaatga caagaaaaaa gaaaaggctt ccgttatgat    720

acagaacaac gcttatgcag tggctgttgc caattatgcc ccgaatcttt caaaagatcc    780

agttctctcc accatctcca agagtgcaac cacgccagaa cccaacaaga agccagaaaa    840

caagccagct gaagcaaaga aaactttcaa cagtgttagc aaaattgaca gaatgtccag    900

aatagttttt ccagttttgt ttggtacctt taatttagtt tactgggcta catatttaaa    960

cagagaacct gtattagggg tcagtccttg aattgagacc catgttatct ttgggatgta   1020

tagcaacatt aaatttggtt tgttttgcta tgtacagtct gactaataac tgctaatttg   1080

tgatccaaca tgtacagtat gtatatagtg acatagctta ccagtagacc tttaatggag   1140

acatgcattt gctaactcat ggaactgcag acagaaagca ctccatgcga aaacagccat   1200

tgcctttttt aaagatttac cctaggacct gatttaaagt gaatttcaag tgacctgatt   1260

aatttcctat tcttccaaat gagatgaaaa tggggatcct gtacaaccct ttgtggaccc   1320

ttttggttta gctcttaagt aggggtattt tctactgttg cttaattatg atggaagata   1380

acattgtcat tcctagatga atcctttgaa gtaacaaaca ttgtatctga catcagctct   1440

gttcatgagt gctcagagtc cctgctaatg taattggaag cttggtacac ataagaaaaa   1500

ctagagattt gaaatcagct atgaattact ctatatagta tctatagcca tgtacatatt   1560

acagcatgac aagctcaaat aattatgagt cagcccgaaa ggatgttaat tatgcctacg   1620

atgtaataac tattggaatg tcatggtcat tacattttta gcttcagagt ttatttgaaa   1680

gtaataattg aaatcctaca atttatttta atcattggaa actaccttaa ttaaaaaaaa   1740

agaaaagaaa tgtgtcttaa catttccagg tatgtgttgt attgaaattg atcagctaaa   1800

ttttacgggt gctggagact ggaaaaagca tccagtttgg ttgctgtgga gcaacatgca   1860

tattggatta gaaaattgtg ccaaaaactc ccactgatga gaattcatag gtgccccaca   1920

ctatgacaaa cacttatatg attctcctct ttcctg                             1956


<210>  2445
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  2445

Met Lys Thr Lys Leu Asn Ile Tyr Asn Met Gln Phe Leu Leu Phe Val 
1               5                   10                  15


Phe Leu Val Trp Asp Pro Ala Arg Leu Val Leu Ala Asn Ile Gln Glu 
            20                  25                  30


Asp Glu Ala Lys Asn Asn Ile Thr Ile Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Asp Ala 
    50                  55                  60


Tyr Thr Thr Ser Glu Val Thr Tyr Ile Trp Thr Tyr Asn Ala Ser Asp 
65                  70                  75                  80


Ser Val Gln Val Ala Pro Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu 
                85                  90                  95


Leu Gly Gln Ser Ile Gly Lys Glu Thr Ile Lys Ser Ser Thr Gly Glu 
            100                 105                 110


Tyr Thr Val Met Thr Ala His Phe His Leu Lys Arg Lys Ile Gly Tyr 
        115                 120                 125


Phe Val Ile Gln Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser 
    130                 135                 140


Gln Val Ser Phe Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val 
145                 150                 155                 160


Phe Gly Val Thr Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala 
                165                 170                 175


Arg Asn Ser Leu Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe 
            180                 185                 190


Ile Ala Val Cys Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala 
        195                 200                 205


Thr Val Asn Tyr Phe Thr Lys Arg Gly Trp Ala Trp Asp Gly Lys Ser 
    210                 215                 220


Val Val Asn Asp Lys Lys Lys Glu Lys Ala Ser Val Met Ile Gln Asn 
225                 230                 235                 240


Asn Ala Tyr Ala Val Ala Val Ala Asn Tyr Ala Pro Asn Leu Ser Lys 
                245                 250                 255


Asp Pro Val Leu Ser Thr Ile Ser Lys Ser Ala Thr Thr Pro Glu Pro 
            260                 265                 270


Asn Lys Lys Pro Glu Asn Lys Pro Ala Glu Ala Lys Lys Thr Phe Asn 
        275                 280                 285


Ser Val Ser Lys Ile Asp Arg Met Ser Arg Ile Val Phe Pro Val Leu 
    290                 295                 300


Phe Gly Thr Phe Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu 
305                 310                 315                 320


Pro Val Leu Gly Val Ser Pro 
                325


<210>  2446
<211>  2994
<212>  DNA
<213>  Homo sapiens

<400>  2446
aaacgcgtcg tttcgcagca cttgatcgga acccggctgc ctctaagact tggtcttggg     60

caaccgtggg tgggcaggaa gggaaattat ttattttatt ttgttaaggg gagtgaagaa    120

aagaagacgt gaggaccgca gttcactgta atgtagagta attgcaaaag tgggctgcct    180

gcccctagct tttcccgctg tggttgcgga ggtggtcttg gttgaggggg ttgtggcgtg    240

aagtacccat ctctcctctc ctctcctttc ctcccctccc ctccaaccca ttccctttcc    300

agctgctatg ccagtttaaa gtccagggtg ttattattac gtgtgcgcaa aacagtgttt    360

gctgacgatg aggctggggg acgttcctgg cagagagaag tctgattact tggtcatctt    420

gctgttaaag aaagaaagaa agaaaaaaag aaagaaagaa acagaaagga aaagggtggg    480

ggtgggggtc cataaaaaag aaatcgtctc tcaatcatca agtcctacac agagtccagg    540

aagtaatctc catagcttta acacgaatcc ctaactaaaa ggatattctt tggggttact    600

tggatagtga aactgaaggc aattttaagt gtattttgtt tttcattcca tggctttgta    660

aagagcggcg gtgatgaaga caaaattgaa catctacaac atgcagttcc tgctttttgt    720

tttcttggtg tgggaccctg ccaggttggt gctggctaac atccaagaag atgaggctaa    780

aaataacatt accatcttta cgagaattct tgacagactt ctggatggtt acgataatcg    840

gcttagacca ggactgggag acagtattac tgaagtcttc actaacatct acgtgaccag    900

ttttggccct gtctcagata cagatatgga atatacaatt gatgttttct ttcgacaaaa    960

atggaaagat gaacgtttaa aatttaaagg tcctatgaat atccttcgac taaacaattt   1020

aatggctagc aaaatctgga ctccagatac cttttttcac aatgggaaaa aatcagtagc   1080

tcataatatg acaatgccaa ataagttgct tcgaattcag gatgatggga ctctgctgta   1140

taccatgagg cttacagttc aagctgaatg cccaatgcac ttggaggatt tcccaatgga   1200

tgctcattca tgtcctctga aatttggcag ctatgcatat acaacttcag aggtcactta   1260

tatttggact tacaatgcat ctgattcagt acaggttgct cctgatggct ctaggttaaa   1320

tcaatatgac ctgctgggcc aatcaatcgg aaaggagaca attaaatcca gtacaggtga   1380

atatactgta atgacagctc atttccacct gaaaagaaaa attgggtatt ttgtgattca   1440

aacctatctg ccttgcatca tgactgtcat tctctcccaa gtttcattct ggcttaacag   1500

agaatctgtg cctgcaagaa ctgtgtttgg agtaacaact gtcctaacaa tgacaactct   1560

aagcatcagt gctcggaatt ctctccccaa agtggcttat gcaactgcca tggactggtt   1620

tattgctgtt tgttatgcat ttgtgttctc tgccctaatt gaatttgcaa ctgttaatta   1680

cttcaccaaa agaggatggg cttgggatgg gaagagtgta gtaaatgaca agaaaaaaga   1740

aaaggcttcc gttatgatac agaacaacgc ttatgcagtg gctgttgcca attatgcccc   1800

gaatctttca aaagatccag ttctctccac catctccaag agtgcaacca cgccagaacc   1860

caacaagaag ccagaaaaca agccagctga agcaaagaaa actttcaaca gtgttagcaa   1920

aattgacaga atgtccagaa tagtttttcc agttttgttt ggtaccttta atttagttta   1980

ctgggctaca tatttaaaca gagaacctgt attaggggtc agtccttgaa ttgagaccca   2040

tgttatcttt gggatgtata gcaacattaa atttggtttg ttttgctatg tacagtctga   2100

ctaataactg ctaatttgtg atccaacatg tacagtatgt atatagtgac atagcttacc   2160

agtagacctt taatggagac atgcatttgc taactcatgg aactgcagac agaaagcact   2220

ccatgcgaaa acagccattg ccttttttaa agatttaccc taggacctga tttaaagtga   2280

atttcaagtg acctgattaa tttcctattc ttccaaatga gatgaaaatg gggatcctgt   2340

acaacccttt gtggaccctt ttggtttagc tcttaagtag gggtattttc tactgttgct   2400

taattatgat ggaagataac attgtcattc ctagatgaat cctttgaagt aacaaacatt   2460

gtatctgaca tcagctctgt tcatgagtgc tcagagtccc tgctaatgta attggaagct   2520

tggtacacat aagaaaaact agagatttga aatcagctat gaattactct atatagtatc   2580

tatagccatg tacatattac agcatgacaa gctcaaataa ttatgagtca gcccgaaagg   2640

atgttaatta tgcctacgat gtaataacta ttggaatgtc atggtcatta catttttagc   2700

ttcagagttt atttgaaagt aataattgaa atcctacaat ttattttaat cattggaaac   2760

taccttaatt aaaaaaaaag aaaagaaatg tgtcttaaca tttccaggta tgtgttgtat   2820

tgaaattgat cagctaaatt ttacgggtgc tggagactgg aaaaagcatc cagtttggtt   2880

gctgtggagc aacatgcata ttggattaga aaattgtgcc aaaaactccc actgatgaga   2940

attcataggt gccccacact atgacaaaca cttatatgat tctcctcttt cctg         2994


<210>  2447
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  2447

Met Lys Thr Lys Leu Asn Ile Tyr Asn Met Gln Phe Leu Leu Phe Val 
1               5                   10                  15


Phe Leu Val Trp Asp Pro Ala Arg Leu Val Leu Ala Asn Ile Gln Glu 
            20                  25                  30


Asp Glu Ala Lys Asn Asn Ile Thr Ile Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Asp Ser 
    50                  55                  60


Ile Thr Glu Val Phe Thr Asn Ile Tyr Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80


Ser Asp Thr Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Lys 
                85                  90                  95


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Asn Ile Leu Arg 
            100                 105                 110


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140


Leu Leu Arg Ile Gln Asp Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160


Thr Val Gln Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175


Ala His Ser Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Thr Ser 
            180                 185                 190


Glu Val Thr Tyr Ile Trp Thr Tyr Asn Ala Ser Asp Ser Val Gln Val 
        195                 200                 205


Ala Pro Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Ser 
    210                 215                 220


Ile Gly Lys Glu Thr Ile Lys Ser Ser Thr Gly Glu Tyr Thr Val Met 
225                 230                 235                 240


Thr Ala His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335


Phe Thr Lys Arg Gly Trp Ala Trp Asp Gly Lys Ser Val Val Asn Asp 
            340                 345                 350


Lys Lys Lys Glu Lys Ala Ser Val Met Ile Gln Asn Asn Ala Tyr Ala 
        355                 360                 365


Val Ala Val Ala Asn Tyr Ala Pro Asn Leu Ser Lys Asp Pro Val Leu 
    370                 375                 380


Ser Thr Ile Ser Lys Ser Ala Thr Thr Pro Glu Pro Asn Lys Lys Pro 
385                 390                 395                 400


Glu Asn Lys Pro Ala Glu Ala Lys Lys Thr Phe Asn Ser Val Ser Lys 
                405                 410                 415


Ile Asp Arg Met Ser Arg Ile Val Phe Pro Val Leu Phe Gly Thr Phe 
            420                 425                 430


Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Val Leu Gly 
        435                 440                 445


Val Ser Pro 
    450


<210>  2448
<211>  2364
<212>  DNA
<213>  Homo sapiens

<400>  2448
aagcggcctc ggggagcagc ccgaggctgc gcgtgggctc cgctcctccg gcgaggtgtg     60

ggcgagggga gcggcgctcc gagcgcaccc aggcgcccga cgccgcccgg gtctgcgccg    120

ctgctagtgc caggcgggcg acgagcggcg gtgatgaaga caaaattgaa catctacaac    180

atgcagttcc tgctttttgt tttcttggtg tgggaccctg ccaggttggt gctggctaac    240

atccaagaag atgaggctaa aaataacatt accatcttta cgagaattct tgacagactt    300

ctggatggtt acgataatcg gcttagacca ggactgggag acagtattac tgaagtcttc    360

actaacatct acgtgaccag ttttggccct gtctcagata cagatatgga atatacaatt    420

gatgttttct ttcgacaaaa atggaaagat gaacgtttaa aatttaaagg tcctatgaat    480

atccttcgac taaacaattt aatggctagc aaaatctgga ctccagatac cttttttcac    540

aatgggaaaa aatcagtagc tcataatatg acaatgccaa ataagttgct tcgaattcag    600

gatgatggga ctctgctgta taccatgagg cttacagttc aagctgaatg cccaatgcac    660

ttggaggatt tcccaatgga tgctcattca tgtcctctga aatttggcag ctatgcatat    720

acaacttcag aggtcactta tatttggact tacaatgcat ctgattcagt acaggttgct    780

cctgatggct ctaggttaaa tcaatatgac ctgctgggcc aatcaatcgg aaaggagaca    840

attaaatcca gtacaggtga atatactgta atgacagctc atttccacct gaaaagaaaa    900

attgggtatt ttgtgattca aacctatctg ccttgcatca tgactgtcat tctctcccaa    960

gtttcattct ggcttaacag agaatctgtg cctgcaagaa ctgtgtttgg agtaacaact   1020

gtcctaacaa tgacaactct aagcatcagt gctcggaatt ctctccccaa agtggcttat   1080

gcaactgcca tggactggtt tattgctgtt tgttatgcat ttgtgttctc tgccctaatt   1140

gaatttgcaa ctgttaatta cttcaccaaa agaggatggg cttgggatgg gaagagtgta   1200

gtaaatgaca aggtaagtga gagcttccgt gttatcatta ttaagaaaat accctaatga   1260

attccgcttg taacagatat gtttctaaaa actgacatta aagacatcca tatatatatg   1320

aatttgaatc atatcaattt cttttaaagt gttcttgcct gaaatccttt aggagttctt   1380

gtagtactaa tacttccatt aaaaccactc cgtagcatct gttgagctgt atgtgtcagg   1440

cactgtgcta agtgttttac atatgctctc tcacataatc tttatagcat ccttatgact   1500

agactgcctt cttattctta tttttactca tgaagaatct gaagcagtaa agttattttc   1560

ttgcccaagc ttacacaact tgttagtaag tatacttgaa ctccgatcta cctgtctgac   1620

tgttaagttc atggttttaa caccacactg cattattata aagagattag aaaaagaaaa   1680

tgggcattaa ttttacttat tatagaattc caggctctat caatgaattg aatcctcttc   1740

acctgttcca gtctctgctg attgattgta aaagcccgga tagcattttt ttaaaatctt   1800

tcccatgttg tatggaataa atatgtcggt gctggaatgc ttaggaattt taaattgttc   1860

atatggtcta aaagggaaaa gttatttgtt tttaagatta acttcttttg agattattgc   1920

tgtccatatt taggtttcaa gtactgaatc taatgggaga tttgtgcatt gatataacag   1980

ctgtttcctt tcatactctg tagattatgt atctgcctaa gaggaggctt tgaatgtatc   2040

ataatcatct atattcttaa taatggtaaa aagttgtatt cagaggatat ctttaacatt   2100

gtatcaacct aaatgcttct tttattaaat ttggattaac atacttgcag atttgatttc   2160

tttttcagtt atttgaatat attttttcat ttctatgacc atgttacagt ttaaatatac   2220

aagcagtaaa tgttatagtt taaaagtctt ggtctttttc cttaattttg taagccatag   2280

aaattttaat aagactgatt atttatttca ttttataagt tgtgttttcc ctactaacgg   2340

agccaacaaa taaatattaa aagg                                          2364


<210>  2449
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  2449

Met Lys Thr Lys Leu Asn Ile Tyr Asn Met Gln Phe Leu Leu Phe Val 
1               5                   10                  15


Phe Leu Val Trp Asp Pro Ala Arg Leu Val Leu Ala Asn Ile Gln Glu 
            20                  25                  30


Asp Glu Ala Lys Asn Asn Ile Thr Ile Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Asp Ser 
    50                  55                  60


Ile Thr Glu Val Phe Thr Asn Ile Tyr Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80


Ser Asp Thr Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Lys 
                85                  90                  95


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Asn Ile Leu Arg 
            100                 105                 110


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140


Leu Leu Arg Ile Gln Asp Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160


Thr Val Gln Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175


Ala His Ser Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Thr Ser 
            180                 185                 190


Glu Val Thr Tyr Ile Trp Thr Tyr Asn Ala Ser Asp Ser Val Gln Val 
        195                 200                 205


Ala Pro Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Ser 
    210                 215                 220


Ile Gly Lys Glu Thr Ile Lys Ser Ser Thr Gly Glu Tyr Thr Val Met 
225                 230                 235                 240


Thr Ala His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335


Phe Thr Lys Arg Gly Trp Ala Trp Asp Gly Lys Ser Val Val Asn Asp 
            340                 345                 350


Lys Val Ser Glu Ser Phe Arg Val Ile Ile Ile Lys Lys Ile Pro 
        355                 360                 365


<210>  2450
<211>  550
<212>  DNA
<213>  Homo sapiens

<400>  2450
cctcagcttt gggtggtggc cgctgccggg catcggcttc cagtccgcgg agggcgaggc     60

ggcgtggaca gcggccccgg cacccagcgc cccgccgccc ggaagccgcg cgcccgtccg    120

ccgcgccccg agcccgccgc ttcctatctc agcgccctgc cgccgccgcc gcggcccagc    180

gagcggccct gatgcaggcc atcaagtttg tggtggtggg agacggagct gtagggtcta    240

gccatggcta aggagattgg tgctgtaaaa tacctggagc gctcggcgct cacacagcga    300

ggcatcaaga cagtgtttga cgaagcgatc cgagcagtcc tctgcccgcc tcccgtgaag    360

aagaggaaga gaaaatgcct gctgttgtaa atgtctcagc ccctcgttct tggtcctgtc    420

ccttggaacc tttgtacgct ttgctcaaaa aaaaaaaaaa aaaccaagaa aaaaaacggt    480

ggagccttcg cactcaatgc caactttttg ttacagatta atttttccat aaaaccattt    540

tttgaaccaa                                                           550


<210>  2451
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  2451

Met Ser Gln Pro Leu Val Leu Gly Pro Val Pro Trp Asn Leu Cys Thr 
1               5                   10                  15


Leu Cys Ser Lys Lys Lys Lys Lys Thr Lys Lys Lys Asn Gly Gly Ala 
            20                  25                  30


Phe Ala Leu Asn Ala Asn Phe Leu Leu Gln Ile Asn Phe Ser Ile Lys 
        35                  40                  45


Pro Phe Phe Glu 
    50


<210>  2452
<211>  863
<212>  DNA
<213>  Homo sapiens

<400>  2452
cagttttcct cagctttggg tggtggccgc tgccgggcat cggcttccat ccgccgcgcc     60

ccgagcccgc cgcttcctat ctcagcgccc tgccgccgcc gccgcggccc agcgagcggc    120

cctgatgcag gccatcaagt ttgtggtggt gggagacgga gctgtaggta aaacttgcct    180

actgatcagt tacacaacca atgcatttcc tggagaatat atccctactg tctttgacaa    240

ttattctgcc aatgttatgg tagatggaaa accggtgaat ctgggcttat gggatacagc    300

tggacaagaa gattatgaca gattacgccc cctatcctat ccgcaaacag atgtgttctt    360

aatttgcttt tcccttgtga gtcctgcatc atttgaaaat gtccgtgcaa agtggtatcc    420

tgaggtgcgg caccactgtc ccaacactcc catcatccta gtgggaacta aacttgatct    480

tagggatgat aaagacccga tcgagaaact gaaggagaag aagctgactc ccatcaccta    540

tccgcagggt ctagccatgg ctaaggagat tggtgctgta aaatacctgg agcgctcggc    600

gctcacacag cgaggcatca agacagtgtt tgacgaagcg atccgagcag tcctctgccc    660

gcctcccgtg aagaagagga agagaaaatg cctgctgttg taaatgtctc agcccctcgt    720

tcttggtcct gtcccttgga acctttgtac gctttgctca aaaaaaaaaa aaaaaaccaa    780

gaaaaaaaac ggtggagcct tcgcactcaa tgccaacttt ttgttacaga ttaatttttc    840

cataaaacca ttttttgaac caa                                            863


<210>  2453
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  2453

Met Gln Ala Ile Lys Phe Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15


Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Ala Phe Pro Gly Glu Tyr 
            20                  25                  30


Ile Pro Thr Val Phe Asp Asn Tyr Ser Ala Asn Val Met Val Asp Gly 
        35                  40                  45


Lys Pro Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln Glu Asp Tyr 
    50                  55                  60


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Ile 
65                  70                  75                  80


Cys Phe Ser Leu Val Ser Pro Ala Ser Phe Glu Asn Val Arg Ala Lys 
                85                  90                  95


Trp Tyr Pro Glu Val Arg His His Cys Pro Asn Thr Pro Ile Ile Leu 
            100                 105                 110


Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Asp Pro Ile Glu Lys 
        115                 120                 125


Leu Lys Glu Lys Lys Leu Thr Pro Ile Thr Tyr Pro Gln Gly Leu Ala 
    130                 135                 140


Met Ala Lys Glu Ile Gly Ala Val Lys Tyr Leu Glu Arg Ser Ala Leu 
145                 150                 155                 160


Thr Gln Arg Gly Ile Lys Thr Val Phe Asp Glu Ala Ile Arg Ala Val 
                165                 170                 175


Leu Cys Pro Pro Pro Val Lys Lys Arg Lys Arg Lys Cys Leu Leu Leu 
            180                 185                 190


<210>  2454
<211>  828
<212>  DNA
<213>  Homo sapiens

<400>  2454
gcagttttcc tcagctttgg gtggtggccg ctgccgggca tcggcttcca gtccgcggag     60

ggcgaggcgg cgtggacagc gcggccctga tgcaggccat caagtttgtg gtggtgggag    120

acggagctgt aggtaaaact tgcctactga tcagttacac aaccaatgca tttcctggag    180

aatatatccc tactgtcttt gacaattatt ctgccaatgt tatggtagat ggaaaaccgg    240

tgaatctggg cttatgggat acagctggac aagaagatta tgacagatta cgccccctat    300

cctatccgca aacagatgtg ttcttaattt gcttttccct tgtgagtcct gcatcatttg    360

aaaatgtccg tgcaaagtgg tatcctgagg tgcggcacca ctgtcccaac actcccatca    420

tcctagtggg aactaaactt gatcttaggg atgataaaga cccgatcgag aaactgaagg    480

agaagaagct gactcccatc acctatccgc agggtctagc catggctaag gagattggtg    540

ctgtaaaata cctggagcgc tcggcgctca cacagcgagg catcaagaca gtgtttgacg    600

aagcgatccg agcagtcctc tgcccgcctc ccgtgaagaa gaggaagaga aaatgcctgc    660

tgttgtaaat gtctcagccc ctcgttcttg gtcctgtccc ttggaacctt tgtacgcttt    720

gctcaaaaaa aaaaaaaaaa accaagaaaa aaaacggtgg agccttcgca ctcaatgcca    780

actttttgtt acagattaat ttttccataa aaccattttt tgaaccaa                 828


<210>  2455
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  2455

Met Gln Ala Ile Lys Phe Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15


Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Ala Phe Pro Gly Glu Tyr 
            20                  25                  30


Ile Pro Thr Val Phe Asp Asn Tyr Ser Ala Asn Val Met Val Asp Gly 
        35                  40                  45


Lys Pro Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln Glu Asp Tyr 
    50                  55                  60


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Ile 
65                  70                  75                  80


Cys Phe Ser Leu Val Ser Pro Ala Ser Phe Glu Asn Val Arg Ala Lys 
                85                  90                  95


Trp Tyr Pro Glu Val Arg His His Cys Pro Asn Thr Pro Ile Ile Leu 
            100                 105                 110


Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Asp Pro Ile Glu Lys 
        115                 120                 125


Leu Lys Glu Lys Lys Leu Thr Pro Ile Thr Tyr Pro Gln Gly Leu Ala 
    130                 135                 140


Met Ala Lys Glu Ile Gly Ala Val Lys Tyr Leu Glu Arg Ser Ala Leu 
145                 150                 155                 160


Thr Gln Arg Gly Ile Lys Thr Val Phe Asp Glu Ala Ile Arg Ala Val 
                165                 170                 175


Leu Cys Pro Pro Pro Val Lys Lys Arg Lys Arg Lys Cys Leu Leu Leu 
            180                 185                 190


<210>  2456
<211>  781
<212>  DNA
<213>  Homo sapiens

<400>  2456
gcagttttcc tcagctttgg gtggtggccg ctgccgggca tcggcttcca gtccgcggag     60

ggcgaggcgg cgtggacagc ggccccggca cccagcgccc cgccgcccgg aagccgcgcg    120

cccgtccgcc gcgccccgag cccgccgctt cctatctcag cgccctgccg ccgccgccgc    180

ggcccagcga gcggccctga tgcaggccat caagtttgtg gtggtgggag acggagctgt    240

aggtaaaact tgcctactga tcagttacac aaccaatgca tttcctggag aatatatccc    300

tactgtcttt gacaattatt ctgccaatgt tatggtagat ggaaaaccgg tgaatctggg    360

cttatgggat acagctggac aagaagatta tgacagatta cgccccctat cctatccgca    420

aacagatgtg ttcttaattt gcttttccct tgtgagtcct gcatcatttg aaaatgtccg    480

tgcaaaattg gtgctgtaaa atacctggag cgctcggcgc tcacacagcg aggcatcaag    540

acagtgtttg acgaagcgat ccgagcagtc ctctgcccgc ctcccgtgaa gaagaggaag    600

agaaaatgcc tgctgttgta aatgtctcag cccctcgttc ttggtcctgt cccttggaac    660

ctttgtacgc tttgctcaaa aaaaaaaaaa aaaaccaaga aaaaaaacgg tggagccttc    720

gcactcaatg ccaacttttt gttacagatt aatttttcca taaaaccatt ttttgaacca    780

a                                                                    781


<210>  2457
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  2457

Met Gln Ala Ile Lys Phe Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15


Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Ala Phe Pro Gly Glu Tyr 
            20                  25                  30


Ile Pro Thr Val Phe Asp Asn Tyr Ser Ala Asn Val Met Val Asp Gly 
        35                  40                  45


Lys Pro Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln Glu Asp Tyr 
    50                  55                  60


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Ile 
65                  70                  75                  80


Cys Phe Ser Leu Val Ser Pro Ala Ser Phe Glu Asn Val Arg Ala Lys 
                85                  90                  95


Leu Val Leu 



<210>  2458
<211>  947
<212>  DNA
<213>  Homo sapiens

<400>  2458
ctatttatgg cagttttcct cagctttggg tggtggccgc tgccgggcat cggcttccag     60

tccgcggagg gcgaggcggc gtggacagcg gccccggcac ccagcgcccc gccgcccgga    120

agccgcgcgc ccgtccgccg cgccccgagc ccgccgcttc ctatctcagc gccctgccgc    180

cgccgccgcg gcccagcgag cggccctgat gcaggccatc aagtttgtgg tggtgggaga    240

cggagctgta ggtaaaactt gcctactgat cagttacaca accaatgcat ttcctggaga    300

atatatccct actgtctttg acaattattc tgccaatgtt atggtagatg gaaaaccggt    360

gaatctgggc ttatgggata cagctggaca agaagattat gacagattac gccccctatc    420

ctatccgcaa acagatgtgt tcttaatttg cttttccctt gtgagtcctg catcatttga    480

aaatgtccgt gcaaagtggt atcctgaggt gcggcaccac tgtcccaaca ctcccatcat    540

cctagtggga actaaacttg atcttaggga tgataaagac ccgatcgaga aactgaagga    600

gaagaagctg actcccatca cctatccgca gggtctagcc atggctaagg agattggtgc    660

tgtaaaatac ctggagcgct cggcgctcac acagcgaggc atcaagacag tgtttgacga    720

agcgatccga gcagtcctct gcccgcctcc cgtgaagaag aggaagagaa aatgcctgct    780

gttgtaaatg tctcagcccc tcgttcttgg tcctgtccct tggaaccttt gtacgctttg    840

ctcaaaaaaa aaaaaaaaaa ccaagaaaaa aaacggtgga gccttcgcac tcaatgccaa    900

ctttttgtta cagattaatt tttccataaa accatttttt gaaccaa                  947


<210>  2459
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  2459

Met Gln Ala Ile Lys Phe Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15


Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Ala Phe Pro Gly Glu Tyr 
            20                  25                  30


Ile Pro Thr Val Phe Asp Asn Tyr Ser Ala Asn Val Met Val Asp Gly 
        35                  40                  45


Lys Pro Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln Glu Asp Tyr 
    50                  55                  60


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Ile 
65                  70                  75                  80


Cys Phe Ser Leu Val Ser Pro Ala Ser Phe Glu Asn Val Arg Ala Lys 
                85                  90                  95


Trp Tyr Pro Glu Val Arg His His Cys Pro Asn Thr Pro Ile Ile Leu 
            100                 105                 110


Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Asp Pro Ile Glu Lys 
        115                 120                 125


Leu Lys Glu Lys Lys Leu Thr Pro Ile Thr Tyr Pro Gln Gly Leu Ala 
    130                 135                 140


Met Ala Lys Glu Ile Gly Ala Val Lys Tyr Leu Glu Arg Ser Ala Leu 
145                 150                 155                 160


Thr Gln Arg Gly Ile Lys Thr Val Phe Asp Glu Ala Ile Arg Ala Val 
                165                 170                 175


Leu Cys Pro Pro Pro Val Lys Lys Arg Lys Arg Lys Cys Leu Leu Leu 
            180                 185                 190


<210>  2460
<211>  629
<212>  DNA
<213>  Homo sapiens

<400>  2460
ggcagttttc ctcagctttg ggtggtggcc gctgccgggc atcggcttcc agtccgcgga     60

gggcgaggcg gcgtggacag cggccccggc acccagcgcc ccgccgcccg gaagccgcgc    120

gcccgtccgc cgcgccccga gcccgccgct tcctatctca gcgccctgcc gccgccgccg    180

cggcccagcg agcggccctg atgcaggcca tcaagtttgt ggtggtggga gacggagctg    240

taggtaaaac ttgcctactg atcagttaca caaccaatgc atttcctgga gaatatatcc    300

ctactgtctt tgacaattat tctgccaatg ttatggtaga tggaaaaccg gtgaatctgg    360

gcttatggga tacagctgga caagaagatt atgacagatt acgcccccta tcctatccgc    420

aaacagatgt gttcttaatt tgcttttccc ttgtgagtcc tgcatcattt gaaaatgtcc    480

gtgcaaagtg gtatcctgag gtgcggcacc actgtcccaa cactcccatc atcctagtgg    540

gaactaaact tgatcttagg gatgataaag acccgatcga gaaagtgaag aagaggaaga    600

gaaaatgcct gctgttgtaa atgtctcag                                      629


<210>  2461
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  2461

Met Gln Ala Ile Lys Phe Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15


Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Ala Phe Pro Gly Glu Tyr 
            20                  25                  30


Ile Pro Thr Val Phe Asp Asn Tyr Ser Ala Asn Val Met Val Asp Gly 
        35                  40                  45


Lys Pro Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln Glu Asp Tyr 
    50                  55                  60


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Ile 
65                  70                  75                  80


Cys Phe Ser Leu Val Ser Pro Ala Ser Phe Glu Asn Val Arg Ala Lys 
                85                  90                  95


Trp Tyr Pro Glu Val Arg His His Cys Pro Asn Thr Pro Ile Ile Leu 
            100                 105                 110


Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Asp Pro Ile Glu Lys 
        115                 120                 125


Val Lys Lys Arg Lys Arg Lys Cys Leu Leu Leu 
    130                 135


<210>  2462
<211>  618
<212>  DNA
<213>  Homo sapiens

<400>  2462
aatttgcctc tgcgccgtct ttttttgcct gttacctgtg acgtccttga aaatgaaaag     60

ctttcttaag acaataggac gggccgggcg cggtggctca tgcctgtaat cctaacactc    120

tgggaggccg aggttggcgg atcacgagga agcagaatct gaaactttct gaggagagca    180

tttgagcttc agatttctaa cagcctcttt gcaacaaaat agaccagtag ctgaaggcaa    240

ctgcaatcct tcatgatgtt tcccttggcc agaaatgcac taagcagtct caagattcaa    300

agcattctgc aaagcatggc aagacatagc catgtaaaac actcaccaga ttttcatgat    360

aaatatggta atgctgtgct agccagtgga actgctttct gtgttgctac atgggtgttt    420

acagccactc agattggaat agaatggaac ctatcccctg ttggcagagt taccccaaaa    480

gagtggaaac atcagtaacc atcacagttg ctgtaatgac agaattgttt aaaaaaccaa    540

cttgtcatgt aagcactcta ctgcttatta aaatatagca caattgaaaa aataaaatgt    600

gttttaaatc tttaaaaa                                                  618


<210>  2463
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  2463

Met Met Phe Pro Leu Ala Arg Asn Ala Leu Ser Ser Leu Lys Ile Gln 
1               5                   10                  15


Ser Ile Leu Gln Ser Met Ala Arg His Ser His Val Lys His Ser Pro 
            20                  25                  30


Asp Phe His Asp Lys Tyr Gly Asn Ala Val Leu Ala Ser Gly Thr Ala 
        35                  40                  45


Phe Cys Val Ala Thr Trp Val Phe Thr Ala Thr Gln Ile Gly Ile Glu 
    50                  55                  60


Trp Asn Leu Ser Pro Val Gly Arg Val Thr Pro Lys Glu Trp Lys His 
65                  70                  75                  80


Gln 



<210>  2464
<211>  536
<212>  DNA
<213>  Homo sapiens

<400>  2464
gtaaaacgga aaggttcgga atttgcctct gcgccgtctt tttttgcctg ttacctgtga     60

cgtccttgga agcagaatct gaaactttct gaggagagca tttgagcttc agatttctaa    120

cagcctcttt gcaacaaaat agaccagtag ctgaaggcaa ctgcaatcct tcatgatgtt    180

tcccttggcc agaaatgcac taagcagtct caagattcaa agcattctgc aaagcatggc    240

aagacatagc catgtaaaac actcaccaga ttttcatgat aaatatggta atgctgtgct    300

agccagtgga actgctttct gtgttgctac atgggtgttt acagccactc agattggaat    360

agaatggaac ctatcccctg ttggcagagt taccccaaaa gagtggaaac atcagtaacc    420

atcacagttg ctgtaatgac agaattgttt aaaaaaccaa cttgtcatgt aagcactcta    480

ctgcttatta aaatatagca caattgaaaa aataaaatgt gttttaaatc tttaaa        536


<210>  2465
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  2465

Met Met Phe Pro Leu Ala Arg Asn Ala Leu Ser Ser Leu Lys Ile Gln 
1               5                   10                  15


Ser Ile Leu Gln Ser Met Ala Arg His Ser His Val Lys His Ser Pro 
            20                  25                  30


Asp Phe His Asp Lys Tyr Gly Asn Ala Val Leu Ala Ser Gly Thr Ala 
        35                  40                  45


Phe Cys Val Ala Thr Trp Val Phe Thr Ala Thr Gln Ile Gly Ile Glu 
    50                  55                  60


Trp Asn Leu Ser Pro Val Gly Arg Val Thr Pro Lys Glu Trp Lys His 
65                  70                  75                  80


Gln 



<210>  2466
<211>  1687
<212>  DNA
<213>  Homo sapiens

<400>  2466
attgcagtac atttgagaaa gtaaaggtgt agtggaaacc gagagcgaaa tgagggcgta     60

gggagaaaag ggtggggaag cttagagacc ggtgagggag cagagctggg gcgcctgtgt    120

acagggatag agcccggcgg cagcagggcg cggcttccct ttcccggggc ctggggccgc    180

aatcaggtgg agtcgagagg ccggaggagg ggcaggagga aggggtgcgg tcgcgatccg    240

gacccggagc cagcgcggag cacctgcgcc cgcggctgac accttcgctc gcagtttgtt    300

cgcagtttac tcgcacacca gtttccccca ccgcgctttg gattagtgtg atctcagctc    360

aaggcaaagg tgggatatca tggcatctat ctgggttgga caccgaggaa cagtaagaga    420

ttatccagac tttagcccat cagtggatgc tgaagctatt cagaaagcaa tcagaggaat    480

tggaactgat gagaaaatgc tcatcagcat tctgactgag aggtcaaatg cacagcggca    540

gctgattgtt aaggaatatc aagcagcata tggaaaggag ctgaaagatg acttgaaggg    600

tgatctctct ggccactttg agcatctcat ggtggcccta gtgactccac cagcagtctt    660

tgatgcaaag cagctaaaga aatccatgaa gggcgcggga acaaacgaag atgccttgat    720

tgaaatctta actaccagga caagcaggca aatgaaggat atctctcaag cctattatac    780

agtatacaag aagagtcttg gagatgacat tagttccgaa acatctggtg acttccggaa    840

agctctgttg actttggcag atggcagaag agatgaaagt ctgaaagtgg atgagcatct    900

ggccaaacaa gatgcccaga ttctctataa agctggtgag aacagatggg gcacggatga    960

agacaaattc actgagatcc tgtgtttaag gagctttcct caattaaaac taacatttga   1020

tgaatacaga aatatcagcc aaaaggacat tgtggacagc ataaaaggag aattatctgg   1080

gcattttgaa gacttactgt tggccatagt taattgtgtg aggaacacgc cggccttttt   1140

agccgaaaga ctgcatcgag ccttgaaggg tattggaact gatgagttta ctctgaaccg   1200

aataatggtg tccagatcag aaattgacct tttggacatt cgaacagagt tcaagaagca   1260

ttatggctat tccctatatt cagcaattaa atcggatact tctggagact atgaaatcac   1320

actcttaaaa atctgtggtg gagatgactg aaccaagaag ataatctcca aaggtccacg   1380

atgggctttc ccaacagctc caccttactt cttctcatac tatttaagag aacaagcaaa   1440

tataaacagc aacttgtgtt cctaacagga attttcattg ttctataaca acaacaacaa   1500

aagcgattat tattttagag catctcattt ataatgtagc agctcataaa tgaaattgaa   1560

aatggtatta aagatctgca actactatcc aacttatatt tctgctttca aagttaagaa   1620

tctttatagt tctactccat taaatataaa gcaagataat aaaaattgtt gcttttgtta   1680

aaagtaa                                                             1687


<210>  2467
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  2467

Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg Asp Tyr Pro 
1               5                   10                  15


Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg 
            20                  25                  30


Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu Thr Glu Arg 
        35                  40                  45


Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr 
    50                  55                  60


Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe 
65                  70                  75                  80


Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val Phe Asp Ala 
                85                  90                  95


Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Thr Asn Glu Asp Ala 
            100                 105                 110


Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln Met Lys Asp Ile 
        115                 120                 125


Ser Gln Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp Asp Ile 
    130                 135                 140


Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala Leu Leu Thr Leu Ala 
145                 150                 155                 160


Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His Leu Ala Lys 
                165                 170                 175


Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly Thr 
            180                 185                 190


Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu Arg Ser Phe Pro Gln 
        195                 200                 205


Leu Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys Asp Ile 
    210                 215                 220


Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu Asp Leu Leu 
225                 230                 235                 240


Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe Leu Ala Glu 
                245                 250                 255


Arg Leu His Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe Thr Leu 
            260                 265                 270


Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile Arg 
        275                 280                 285


Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys 
    290                 295                 300


Ser Asp Thr Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys Gly 
305                 310                 315                 320


Gly Asp Asp 



<210>  2468
<211>  1037
<212>  DNA
<213>  Homo sapiens

<400>  2468
gcagggcgcg gcttcccttt cccggggcct ggggccgcaa tcaggtggag tcgagaggcc     60

ggaggagggg caggaggaag gggtgcggtc gcgatccgga cccggagcca gcgcggagca    120

cctgcgcccg cggctgacac cttcgctcgc agtttgttcg cagtttactc gcacaccagt    180

ttcccccacc gcgctttgga ttagtgtgat ctcagctcaa ggcaaaggtg ggatatcatg    240

gcatctatct gggttggaca ccgaggaaca gtaagagatt atccagactt tagcccatca    300

gtggatgctg aagctattca gaaagcaatc agaggaattg gaactgatga gaaaatgctc    360

atcagcattc tgactgagag gtcaaatgca cagcggcagc tgattgttaa ggaatatcaa    420

gcagcatatg gaaaggagct gaaagatgac ttgaagggtg atctctctgg ccactttgag    480

catctcatgg tggccctagt gactccacca gcagtctttg atgcaaagca gctaaagaaa    540

tccatgaagg tatgagcccc ccacaagcca tttctgccca gggtttgacc aagtcatcaa    600

aaatagtgac tttcttgcag tgcacacttg tgatgggtgg acttggatgc ccttttggtc    660

tggactctcc cagtggtaga atgactctga aataggcaac agctatagaa ccttaagccc    720

aaatgttcct gggctggaag aattttgtca tatcctttgt ttgacatgaa gagtcaagtt    780

ctctaatttg tcatcgttga aagtaaatag cactatgatt aaccccaaca ctcaagctaa    840

aaacctagca ttatccttga gcccttgttt tctcttaccc ttccaagctc ccaaatctat    900

cagcaagttc cttagtttta cttcaaaatc cattataaat atgtgcactt ctctcaaaat    960

ccattgctac tgttctagtc tgaccaccat catctcttga ctggtccata tcaataggct   1020

tctaactggt ccctttg                                                  1037


<210>  2469
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  2469

Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg Asp Tyr Pro 
1               5                   10                  15


Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg 
            20                  25                  30


Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu Thr Glu Arg 
        35                  40                  45


Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr 
    50                  55                  60


Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe 
65                  70                  75                  80


Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val Phe Asp Ala 
                85                  90                  95


Lys Gln Leu Lys Lys Ser Met Lys Val 
            100                 105


<210>  2470
<211>  1371
<212>  DNA
<213>  Homo sapiens

<400>  2470
ggtcgcgatc cggacccgga gccagcgcgg agcacctgcg cccgcggctg acaccttcgc     60

tcgcagtttg ttcgcagttt actcgcacac cagtttcccc caccgcgctt tggattagtg    120

tgatctcagc tcaaggcaaa ggtgggatat catggcatct atctgggaac tgatgagaaa    180

atgctcatca gcattctgac tgagaggtca aatgcacagc ggcagctgat tgttaaggaa    240

tatcaagcag catatggaaa ggagctgaaa gatgacttga agggtgatct ctctggccac    300

tttgagcatc tcatggtggc cctagtgact ccaccagcag tctttgatgc aaagcagcta    360

aagaaatcca tgaagggcgc gggaacaaac gaagatgcct tgattgaaat cttaactacc    420

aggacaagca ggcaaatgaa ggatatctct caagcctatt atacagtata caagaagagt    480

cttggagatg acattagttc cgaaacatct ggtgacttcc ggaaagctct gttgactttg    540

gcagatggca gaagagatga aagtctgaaa gtggatgagc atctggccaa acaagatgcc    600

cagattctct ataaagctgg tgagaacaga tggggcacgg atgaagacaa attcactgag    660

atcctgtgtt taaggagctt tcctcaatta aaactaacat ttgatgaata cagaaatatc    720

agccaaaagg acattgtgga cagcataaaa ggagaattat ctgggcattt tgaagactta    780

ctgttggcca tagttaattg tgtgaggaac acgccggcct ttttagccga aagactgcat    840

cgagccttga agggtattgg aactgatgag tttactctga accgaataat ggtgtccaga    900

tcagaaattg accttttgga cattcgaaca gagttcaaga agcattatgg ctattcccta    960

tattcagcaa ttaaatcgga tacttctgga gactatgaaa tcacactctt aaaaatctgt   1020

ggtggagatg actgaaccaa gaagataatc tccaaaggtc cacgatgggc tttcccaaca   1080

gctccacctt acttcttctc atactattta agagaacaag caaatataaa cagcaacttg   1140

tgttcctaac aggaattttc attgttctat aacaacaaca acaaaagcga ttattatttt   1200

agagcatctc atttataatg tagcagctca taaatgaaat tgaaaatggt attaaagatc   1260

tgcaactact atccaactta tatttctgct ttcaaagtta agaatcttta tagttctact   1320

ccattaaata taaagcaaga taataaaaat tgttgctttt gttaaaagta a            1371


<210>  2471
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  2471

Met Leu Ile Ser Ile Leu Thr Glu Arg Ser Asn Ala Gln Arg Gln Leu 
1               5                   10                  15


Ile Val Lys Glu Tyr Gln Ala Ala Tyr Gly Lys Glu Leu Lys Asp Asp 
            20                  25                  30


Leu Lys Gly Asp Leu Ser Gly His Phe Glu His Leu Met Val Ala Leu 
        35                  40                  45


Val Thr Pro Pro Ala Val Phe Asp Ala Lys Gln Leu Lys Lys Ser Met 
    50                  55                  60


Lys Gly Ala Gly Thr Asn Glu Asp Ala Leu Ile Glu Ile Leu Thr Thr 
65                  70                  75                  80


Arg Thr Ser Arg Gln Met Lys Asp Ile Ser Gln Ala Tyr Tyr Thr Val 
                85                  90                  95


Tyr Lys Lys Ser Leu Gly Asp Asp Ile Ser Ser Glu Thr Ser Gly Asp 
            100                 105                 110


Phe Arg Lys Ala Leu Leu Thr Leu Ala Asp Gly Arg Arg Asp Glu Ser 
        115                 120                 125


Leu Lys Val Asp Glu His Leu Ala Lys Gln Asp Ala Gln Ile Leu Tyr 
    130                 135                 140


Lys Ala Gly Glu Asn Arg Trp Gly Thr Asp Glu Asp Lys Phe Thr Glu 
145                 150                 155                 160


Ile Leu Cys Leu Arg Ser Phe Pro Gln Leu Lys Leu Thr Phe Asp Glu 
                165                 170                 175


Tyr Arg Asn Ile Ser Gln Lys Asp Ile Val Asp Ser Ile Lys Gly Glu 
            180                 185                 190


Leu Ser Gly His Phe Glu Asp Leu Leu Leu Ala Ile Val Asn Cys Val 
        195                 200                 205


Arg Asn Thr Pro Ala Phe Leu Ala Glu Arg Leu His Arg Ala Leu Lys 
    210                 215                 220


Gly Ile Gly Thr Asp Glu Phe Thr Leu Asn Arg Ile Met Val Ser Arg 
225                 230                 235                 240


Ser Glu Ile Asp Leu Leu Asp Ile Arg Thr Glu Phe Lys Lys His Tyr 
                245                 250                 255


Gly Tyr Ser Leu Tyr Ser Ala Ile Lys Ser Asp Thr Ser Gly Asp Tyr 
            260                 265                 270


Glu Ile Thr Leu Leu Lys Ile Cys Gly Gly Asp Asp 
        275                 280


<210>  2472
<211>  1600
<212>  DNA
<213>  Homo sapiens

<400>  2472
ggtcgcgatc cggacccgga gccagcgcgg agcacctgcg cccgcggctg acaccttcgc     60

tcgcagtttg ttcgcagttt actcgcacac cagtttcccc caccgcgctt tggattagtg    120

tgatctcagc tcaaggcaaa ggtgggatat catggcatct atctggacac ggtctcactc    180

tgtcacctag actacagtgc agtgacacaa tcacagctca ctgcagcctt gaccttctgc    240

gctcaagtgg tcctcccacc tcagcctccc aagtagctgg gaccacacct gcacaccacc    300

acacctggtt ggacaccgag gaacagtaag agattatcca gactttagcc catcagtgga    360

tgctgaagct attcagaaag caatcagagg aattggaact gatgagaaaa tgctcatcag    420

cattctgact gagaggtcaa atgcacagcg gcagctgatt gttaaggaat atcaagcagc    480

atatggaaag gagctgaaag atgacttgaa gggtgatctc tctggccact ttgagcatct    540

catggtggcc ctagtgactc caccagcagt ctttgatgca aagcagctaa agaaatccat    600

gaagggcgcg ggaacaaacg aagatgcctt gattgaaatc ttaactacca ggacaagcag    660

gcaaatgaag gatatctctc aagcctatta tacagtatac aagaagagtc ttggagatga    720

cattagttcc gaaacatctg gtgacttccg gaaagctctg ttgactttgg cagatggcag    780

aagagatgaa agtctgaaag tggatgagca tctggccaaa caagatgccc agattctcta    840

taaagctggt gagaacagat ggggcacgga tgaagacaaa ttcactgaga tcctgtgttt    900

aaggagcttt cctcaattaa aactaacatt tgatgaatac agaaatatca gccaaaagga    960

cattgtggac agcataaaag gagaattatc tgggcatttt gaagacttac tgttggccat   1020

agttaattgt gtgaggaaca cgccggcctt tttagccgaa agactgcatc gagccttgaa   1080

gggtattgga actgatgagt ttactctgaa ccgaataatg gtgtccagat cagaaattga   1140

ccttttggac attcgaacag agttcaagaa gcattatggc tattccctat attcagcaat   1200

taaatcggat acttctggag actatgaaat cacactctta aaaatctgtg gtggagatga   1260

ctgaaccaag aagataatct ccaaaggtcc acgatgggct ttcccaacag ctccacctta   1320

cttcttctca tactatttaa gagaacaagc aaatataaac agcaacttgt gttcctaaca   1380

ggaattttca ttgttctata acaacaacaa caaaagcgat tattatttta gagcatctca   1440

tttataatgt agcagctcat aaatgaaatt gaaaatggta ttaaagatct gcaactacta   1500

tccaacttat atttctgctt tcaaagttaa gaatctttat agttctactc cattaaatat   1560

aaagcaagat aataaaaatt gttgcttttg ttaaaagtaa                         1600


<210>  2473
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  2473

Met Leu Ile Ser Ile Leu Thr Glu Arg Ser Asn Ala Gln Arg Gln Leu 
1               5                   10                  15


Ile Val Lys Glu Tyr Gln Ala Ala Tyr Gly Lys Glu Leu Lys Asp Asp 
            20                  25                  30


Leu Lys Gly Asp Leu Ser Gly His Phe Glu His Leu Met Val Ala Leu 
        35                  40                  45


Val Thr Pro Pro Ala Val Phe Asp Ala Lys Gln Leu Lys Lys Ser Met 
    50                  55                  60


Lys Gly Ala Gly Thr Asn Glu Asp Ala Leu Ile Glu Ile Leu Thr Thr 
65                  70                  75                  80


Arg Thr Ser Arg Gln Met Lys Asp Ile Ser Gln Ala Tyr Tyr Thr Val 
                85                  90                  95


Tyr Lys Lys Ser Leu Gly Asp Asp Ile Ser Ser Glu Thr Ser Gly Asp 
            100                 105                 110


Phe Arg Lys Ala Leu Leu Thr Leu Ala Asp Gly Arg Arg Asp Glu Ser 
        115                 120                 125


Leu Lys Val Asp Glu His Leu Ala Lys Gln Asp Ala Gln Ile Leu Tyr 
    130                 135                 140


Lys Ala Gly Glu Asn Arg Trp Gly Thr Asp Glu Asp Lys Phe Thr Glu 
145                 150                 155                 160


Ile Leu Cys Leu Arg Ser Phe Pro Gln Leu Lys Leu Thr Phe Asp Glu 
                165                 170                 175


Tyr Arg Asn Ile Ser Gln Lys Asp Ile Val Asp Ser Ile Lys Gly Glu 
            180                 185                 190


Leu Ser Gly His Phe Glu Asp Leu Leu Leu Ala Ile Val Asn Cys Val 
        195                 200                 205


Arg Asn Thr Pro Ala Phe Leu Ala Glu Arg Leu His Arg Ala Leu Lys 
    210                 215                 220


Gly Ile Gly Thr Asp Glu Phe Thr Leu Asn Arg Ile Met Val Ser Arg 
225                 230                 235                 240


Ser Glu Ile Asp Leu Leu Asp Ile Arg Thr Glu Phe Lys Lys His Tyr 
                245                 250                 255


Gly Tyr Ser Leu Tyr Ser Ala Ile Lys Ser Asp Thr Ser Gly Asp Tyr 
            260                 265                 270


Glu Ile Thr Leu Leu Lys Ile Cys Gly Gly Asp Asp 
        275                 280


<210>  2474
<211>  1540
<212>  DNA
<213>  Homo sapiens

<400>  2474
actcgcacac cagtttcccc caccgcgctt tggctagcag cgtaagggat ccacttagcc     60

atctcggcct ccccagtcct aaaggtctag gggacagaaa aaagctggga gtcggaaggt    120

tcctcgggtc cccggcatgg cagacggggc tggctcagag gtctgctctg tggacttgga    180

atcgcaccca tcctattagt gtgatctcag ctcaaggcaa aggtgggata tcatggcatc    240

tatctgggtt ggacaccgag gaacagtaag agattatcca gactttagcc catcagtgga    300

tgctgaagct attcagaaag caatcagagg aattggaact gatgagaaaa tgctcatcag    360

cattctgact gagaggtcaa atgcacagcg gcagctgatt gttaaggaat atcaagcagc    420

atatggaaag gagctgaaag atgacttgaa gggtgatctc tctggccact ttgagcatct    480

catggtggcc ctagtgactc caccagcagt ctttgatgca aagcagctaa agaaatccat    540

gaagggcgcg ggaacaaacg aagatgcctt gattgaaatc ttaactacca ggacaagcag    600

gcaaatgaag gatatctctc aagcctatta tacagtatac aagaagagtc ttggagatga    660

cattagttcc gaaacatctg gtgacttccg gaaagctctg ttgactttgg cagatggcag    720

aagagatgaa agtctgaaag tggatgagca tctggccaaa caagatgccc agattctcta    780

taaagctggt gagaacagat ggggcacgga tgaagacaaa ttcactgaga tcctgtgttt    840

aaggagcttt cctcaattaa aactaacatt tgatgaatac agaaatatca gccaaaagga    900

cattgtggac agcataaaag gagaattatc tgggcatttt gaagacttac tgttggccat    960

agttaattgt gtgaggaaca cgccggcctt tttagccgaa agactgcatc gagccttgaa   1020

gggtattgga actgatgagt ttactctgaa ccgaataatg gtgtccagat cagaaattga   1080

ccttttggac attcgaacag agttcaagaa gcattatggc tattccctat attcagcaat   1140

taaatcggat acttctggag actatgaaat cacactctta aaaatctgtg gtggagatga   1200

ctgaaccaag aagataatct ccaaaggtcc acgatgggct ttcccaacag ctccacctta   1260

cttcttctca tactatttaa gagaacaagc aaatataaac agcaacttgt gttcctaaca   1320

ggaattttca ttgttctata acaacaacaa caaaagcgat tattatttta gagcatctca   1380

tttataatgt agcagctcat aaatgaaatt gaaaatggta ttaaagatct gcaactacta   1440

tccaacttat atttctgctt tcaaagttaa gaatctttat agttctactc cattaaatat   1500

aaagcaagat aataaaaatt gttgcttttg ttaaaagtaa                         1540


<210>  2475
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  2475

Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg Asp Tyr Pro 
1               5                   10                  15


Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg 
            20                  25                  30


Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu Thr Glu Arg 
        35                  40                  45


Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr 
    50                  55                  60


Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe 
65                  70                  75                  80


Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val Phe Asp Ala 
                85                  90                  95


Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Thr Asn Glu Asp Ala 
            100                 105                 110


Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln Met Lys Asp Ile 
        115                 120                 125


Ser Gln Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp Asp Ile 
    130                 135                 140


Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala Leu Leu Thr Leu Ala 
145                 150                 155                 160


Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His Leu Ala Lys 
                165                 170                 175


Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly Thr 
            180                 185                 190


Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu Arg Ser Phe Pro Gln 
        195                 200                 205


Leu Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys Asp Ile 
    210                 215                 220


Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu Asp Leu Leu 
225                 230                 235                 240


Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe Leu Ala Glu 
                245                 250                 255


Arg Leu His Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe Thr Leu 
            260                 265                 270


Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile Arg 
        275                 280                 285


Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys 
    290                 295                 300


Ser Asp Thr Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys Gly 
305                 310                 315                 320


Gly Asp Asp 



<210>  2476
<211>  1725
<212>  DNA
<213>  Homo sapiens

<400>  2476
ctcgaccctg ggcagggctg gcggctggcg cccgcgcccg gccccaaccc agctgcgtgg     60

gtggggagct ggagggacct cagtcctgca tttcagagtc gaggagactg ggcccacggg    120

ggggaaagtg ccgtgccatg ggtgggtcac ccaggtcttg gtggggccca agctgatact    180

cagctgtcct cgctccctga aagcttcgct tattacagct agcagcgtaa gggatccact    240

tagccatctc ggcctcccca gtcctaaagg tctaggggac agaaaaaagc tgggagtcgg    300

aaggttcctc gggtccccgg catggcagac ggggctggct cagaggtctg ctctgtggac    360

ttggaatcgc acccatccta ttagtgtgat ctcagctcaa ggcaaaggtg ggatatcatg    420

gcatctatct gggttggaca ccgaggaaca gtaagagatt atccagactt tagcccatca    480

gtggatgctg aagctattca gaaagcaatc agaggaattg gaactgatga gaaaatgctc    540

atcagcattc tgactgagag gtcaaatgca cagcggcagc tgattgttaa ggaatatcaa    600

gcagcatatg gaaaggagct gaaagatgac ttgaagggtg atctctctgg ccactttgag    660

catctcatgg tggccctagt gactccacca gcagtctttg atgcaaagca gctaaagaaa    720

tccatgaagg gcgcgggaac aaacgaagat gccttgattg aaatcttaac taccaggaca    780

agcaggcaaa tgaaggatat ctctcaagcc tattatacag tatacaagaa gagtcttgga    840

gatgacatta gttccgaaac atctggtgac ttccggaaag ctctgttgac tttggcagat    900

ggcagaagag atgaaagtct gaaagtggat gagcatctgg ccaaacaaga tgcccagatt    960

ctctataaag ctggtgagaa cagatggggc acggatgaag acaaattcac tgagatcctg   1020

tgtttaagga gctttcctca attaaaacta acatttgatg aatacagaaa tatcagccaa   1080

aaggacattg tggacagcat aaaaggagaa ttatctgggc attttgaaga cttactgttg   1140

gccatagtta attgtgtgag gaacacgccg gcctttttag ccgaaagact gcatcgagcc   1200

ttgaagggta ttggaactga tgagtttact ctgaaccgaa taatggtgtc cagatcagaa   1260

attgaccttt tggacattcg aacagagttc aagaagcatt atggctattc cctatattca   1320

gcaattaaat cggatacttc tggagactat gaaatcacac tcttaaaaat ctgtggtgga   1380

gatgactgaa ccaagaagat aatctccaaa ggtccacgat gggctttccc aacagctcca   1440

ccttacttct tctcatacta tttaagagaa caagcaaata taaacagcaa cttgtgttcc   1500

taacaggaat tttcattgtt ctataacaac aacaacaaaa gcgattatta ttttagagca   1560

tctcatttat aatgtagcag ctcataaatg aaattgaaaa tggtattaaa gatctgcaac   1620

tactatccaa cttatatttc tgctttcaaa gttaagaatc tttatagttc tactccatta   1680

aatataaagc aagataataa aaattgttgc ttttgttaaa agtaa                   1725


<210>  2477
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  2477

Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg Asp Tyr Pro 
1               5                   10                  15


Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg 
            20                  25                  30


Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu Thr Glu Arg 
        35                  40                  45


Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr 
    50                  55                  60


Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe 
65                  70                  75                  80


Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val Phe Asp Ala 
                85                  90                  95


Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Thr Asn Glu Asp Ala 
            100                 105                 110


Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln Met Lys Asp Ile 
        115                 120                 125


Ser Gln Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp Asp Ile 
    130                 135                 140


Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala Leu Leu Thr Leu Ala 
145                 150                 155                 160


Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His Leu Ala Lys 
                165                 170                 175


Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly Thr 
            180                 185                 190


Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu Arg Ser Phe Pro Gln 
        195                 200                 205


Leu Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys Asp Ile 
    210                 215                 220


Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu Asp Leu Leu 
225                 230                 235                 240


Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe Leu Ala Glu 
                245                 250                 255


Arg Leu His Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe Thr Leu 
            260                 265                 270


Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile Arg 
        275                 280                 285


Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys 
    290                 295                 300


Ser Asp Thr Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys Gly 
305                 310                 315                 320


Gly Asp Asp 



<210>  2478
<211>  1472
<212>  DNA
<213>  Homo sapiens

<400>  2478
cctcctcaaa gagcagatgt gtctttataa cagactgtag gcttggagcc ttgtaaaatg     60

tacatggagt ttcacaatca agcacaagga atccaactga aggcagctaa actttgtgtt    120

gatttgatta gtgtgatctc agctcaaggc aaaggtggga tatcatggca tctatctggg    180

ttggacaccg aggaacagta agagattatc cagactttag cccatcagtg gatgctgaag    240

ctattcagaa agcaatcaga ggaattggaa ctgatgagaa aatgctcatc agcattctga    300

ctgagaggtc aaatgcacag cggcagctga ttgttaagga atatcaagca gcatatggaa    360

aggagctgaa agatgacttg aagggtgatc tctctggcca ctttgagcat ctcatggtgg    420

ccctagtgac tccaccagca gtctttgatg caaagcagct aaagaaatcc atgaagggcg    480

cgggaacaaa cgaagatgcc ttgattgaaa tcttaactac caggacaagc aggcaaatga    540

aggatatctc tcaagcctat tatacagtat acaagaagag tcttggagat gacattagtt    600

ccgaaacatc tggtgacttc cggaaagctc tgttgacttt ggcagatggc agaagagatg    660

aaagtctgaa agtggatgag catctggcca aacaagatgc ccagattctc tataaagctg    720

gtgagaacag atggggcacg gatgaagaca aattcactga gatcctgtgt ttaaggagct    780

ttcctcaatt aaaactaaca tttgatgaat acagaaatat cagccaaaag gacattgtgg    840

acagcataaa aggagaatta tctgggcatt ttgaagactt actgttggcc atagttaatt    900

gtgtgaggaa cacgccggcc tttttagccg aaagactgca tcgagccttg aagggtattg    960

gaactgatga gtttactctg aaccgaataa tggtgtccag atcagaaatt gaccttttgg   1020

acattcgaac agagttcaag aagcattatg gctattccct atattcagca attaaatcgg   1080

atacttctgg agactatgaa atcacactct taaaaatctg tggtggagat gactgaacca   1140

agaagataat ctccaaaggt ccacgatggg ctttcccaac agctccacct tacttcttct   1200

catactattt aagagaacaa gcaaatataa acagcaactt gtgttcctaa caggaatttt   1260

cattgttcta taacaacaac aacaaaagcg attattattt tagagcatct catttataat   1320

gtagcagctc ataaatgaaa ttgaaaatgg tattaaagat ctgcaactac tatccaactt   1380

atatttctgc tttcaaagtt aagaatcttt atagttctac tccattaaat ataaagcaag   1440

ataataaaaa ttgttgcttt tgttaaaagt aa                                 1472


<210>  2479
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  2479

Met Ala Ser Ile Trp Val Gly His Arg Gly Thr Val Arg Asp Tyr Pro 
1               5                   10                  15


Asp Phe Ser Pro Ser Val Asp Ala Glu Ala Ile Gln Lys Ala Ile Arg 
            20                  25                  30


Gly Ile Gly Thr Asp Glu Lys Met Leu Ile Ser Ile Leu Thr Glu Arg 
        35                  40                  45


Ser Asn Ala Gln Arg Gln Leu Ile Val Lys Glu Tyr Gln Ala Ala Tyr 
    50                  55                  60


Gly Lys Glu Leu Lys Asp Asp Leu Lys Gly Asp Leu Ser Gly His Phe 
65                  70                  75                  80


Glu His Leu Met Val Ala Leu Val Thr Pro Pro Ala Val Phe Asp Ala 
                85                  90                  95


Lys Gln Leu Lys Lys Ser Met Lys Gly Ala Gly Thr Asn Glu Asp Ala 
            100                 105                 110


Leu Ile Glu Ile Leu Thr Thr Arg Thr Ser Arg Gln Met Lys Asp Ile 
        115                 120                 125


Ser Gln Ala Tyr Tyr Thr Val Tyr Lys Lys Ser Leu Gly Asp Asp Ile 
    130                 135                 140


Ser Ser Glu Thr Ser Gly Asp Phe Arg Lys Ala Leu Leu Thr Leu Ala 
145                 150                 155                 160


Asp Gly Arg Arg Asp Glu Ser Leu Lys Val Asp Glu His Leu Ala Lys 
                165                 170                 175


Gln Asp Ala Gln Ile Leu Tyr Lys Ala Gly Glu Asn Arg Trp Gly Thr 
            180                 185                 190


Asp Glu Asp Lys Phe Thr Glu Ile Leu Cys Leu Arg Ser Phe Pro Gln 
        195                 200                 205


Leu Lys Leu Thr Phe Asp Glu Tyr Arg Asn Ile Ser Gln Lys Asp Ile 
    210                 215                 220


Val Asp Ser Ile Lys Gly Glu Leu Ser Gly His Phe Glu Asp Leu Leu 
225                 230                 235                 240


Leu Ala Ile Val Asn Cys Val Arg Asn Thr Pro Ala Phe Leu Ala Glu 
                245                 250                 255


Arg Leu His Arg Ala Leu Lys Gly Ile Gly Thr Asp Glu Phe Thr Leu 
            260                 265                 270


Asn Arg Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile Arg 
        275                 280                 285


Thr Glu Phe Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys 
    290                 295                 300


Ser Asp Thr Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys Gly 
305                 310                 315                 320


Gly Asp Asp 



<210>  2480
<211>  1301
<212>  DNA
<213>  Homo sapiens

<400>  2480
tgaaaaacaa aaaccagata accctaggtc tctctccaaa atttcttttt ttaaaaatgt     60

attggggaaa aatatacttg gcttacaaaa tatgcctgta tacttggtga catatgtaca    120

ggttttgctt ggggcaaata ctgatcaaga aattcaaatg ccttctggga ggtgtgaagt    180

aggccatgcc accttaggaa atgattcagc acaaggaagt cttcagaatt aagatttctt    240

taccagagaa aacatatttg actagtgatt atagtatcat ttcccaggtg ctgctataaa    300

taaaatttaa aatagcccaa cttactggat aaattattta ttatttaact atttaggcta    360

tttaaaatgc ttactgcttg agagaagggg aaagagaaag agagatcatt gaagaaaatc    420

atctagggag tttgggtttt gttgtagatg atttccttaa aaaggaacaa aagaaaaaca    480

aaaacttctg tgcccagatt ttcatggttt aaagagggag ttttttagct tgctacttga    540

tcttctgcat atcaaataaa aaactagaat atattcaaat gtgctcaact gcgttgcttt    600

aaataatttt gtggtgcttc tttttagcat ttgatgaata cagaaatatc agccaaaagg    660

acattgtgga cagcataaaa ggagaattat ctgggcattt tgaagactta ctgttggcca    720

tagttaattg tgtgaggaac acgccggcct ttttagccga aagactgcat cgagccttga    780

agggtattgg aactgatgag tttactctga accgaataat ggtgtccaga tcagaaattg    840

accttttgga cattcgaaca gagttcaaga agcattatgg ctattcccta tattcagcaa    900

ttaaatcgga tacttctgga gactatgaaa tcacactctt aaaaatctgt ggtggagatg    960

actgaaccaa gaagataatc tccaaaggtc cacgatgggc tttcccaaca gctccacctt   1020

acttcttctc atactattta agagaacaag caaatataaa cagcaacttg tgttcctaac   1080

aggaattttc attgttctat aacaacaaca acaaaagcga ttattatttt agagcatctc   1140

atttataatg tagcagctca taaatgaaat tgaaaatggt attaaagatc tgcaactact   1200

atccaactta tatttctgct ttcaaagtta agaatcttta tagttctact ccattaaata   1260

taaagcaaga taataaaaat tgttgctttt gttaaaagta a                       1301


<210>  2481
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  2481

Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile Arg Thr Glu Phe 
1               5                   10                  15


Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys Ser Asp Thr 
            20                  25                  30


Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys Gly Gly Asp Asp 
        35                  40                  45


<210>  2482
<211>  2932
<212>  DNA
<213>  Homo sapiens

<400>  2482
agatgctaat attccacttg tatgaaagat gaaaattcat gtataatatt aaattttaaa     60

agttcatcct ctattttaaa tagaaaatga gaaggcaggc caggcgcggt ggctcacgcc    120

tgtaatccca gcattttagg aggcccaggc gggtggatca caaggtcagg agttcaagac    180

cagcctggcc agacggtgaa accctgtctc tactaaaaat acaaaaatta gccgggcgtg    240

gtagcagatg cactgtaatc ccagctactc gcgaggctga ggcagagaat tgcttgaacc    300

caggaggcag aggttgcagt gagcctagat tgcgccactg cactccagtc tgggcgacag    360

agtgagactc tgtctcaaaa aaaaaaaaaa aaaaagaaaa tgagaaggta aaaatatggc    420

ttaatgttga tagaatgtca tatttctttt ccacttagat tagttttcta cagtagctaa    480

tttgtctact gatttgcctc ataggttaat agtattctaa cccatataga gataggtaca    540

gagaagtatt gaccacatta ttttcactgc ttcacagtaa gtgcaggcag taaaacttgt    600

tttagaatgc caaacctcaa gcttgagacc cagtagatcc tgtggcctct caaactgcct    660

tgcttaaaat aaaccaagct gagttggcag cctttaatga tgccgtaacc ctgtgtttgc    720

ttgtctgtct ttactgccag atggtgcgct ccatgagtac agactcctgt ttatcctcag    780

accctagggc cttgtgcaca gaagatgctt acctccatct ctttaccagc cattttctgt    840

ggtcccacac gtaccttcaa agtcatatcc taagtgaaca catcctttcc ttcatctcgc    900

ccagccccac atctgctccc cttcccctgt tcagtcatcc cagagaatgg ccccaacagg    960

aatttgccca actctctgaa gtcgtaccat tcctccccag acttcttgac tatgcctcag   1020

ccaccccagg cttctttcca ttcctcaact gtggcaagtc tattctcaca tcacagtctt   1080

tgcatccatt ccttctctgg aatgctcatc ctctagatct ttacctagct gactccttct   1140

catctttcag gtttcagctc tcctcctgag agaggtctcc cctaactgta ccaggccaat   1200

tggttccctt tcagtcactc tccatgccat ttccagcttt cttttcttca tatttctgat   1260

cactatttac ttaagcaata gttaatttgc tttgctgtct gtctccatct actagaacat   1320

aagctccatg cagacagaga tataatctgt tctgttcacc gccattggca cagcacatgg   1380

aataatgcct ggctatagtc gacgctcata agcatttgct ggatgaatta catagatgaa   1440

tggaatatca tttagtatgt tggccatcat taggtcaaaa tccacctaac tgctcagcta   1500

gaaattttac actatctctc tttttcatta tcctgtagcg atacatcatt atgttttgtc   1560

aatccattta cataagcaac tctcaaatct tcccattttc tccatcccta ctgcctttat   1620

tctaaggatg gccatcatca tctcttaatt actcagtctc ctcaagatga gtctcaaagc   1680

ctctagtctt aactccctta tcttccttct actcctacct tgcaatctgt ttctcatgct   1740

gcagtcaaag tgattttctg aaaccacgaa tttgatctga tctcaacatt ctcatgttta   1800

aaatattaca agagctctcc acacttagga taaagtcaga atttcatttc atggttaaca   1860

aggtctggcc tttccagaca catttctttt tatccctctt tgttaactta cgtatccttg   1920

aacgtggcgt tctttattgc cctaaacctt cacgcctgct atttcctcta taggaagttt   1980

ctctcctccc tacatgaacc tactccttcc tcttgttgac tgtttagtcc ttgcttaaat   2040

gtcactttct cagacttttc ctaatcccta atctttctta ggcccccctg aagtatgctc   2100

ccatggtacc caatattttc aacatgtcag actgttttgc aatggcttac tttcttgcct   2160

gtattcttta caaaactgga agcttaacat gggtatctca tctctgcttt gcagcattta   2220

gcatgatgct gtcacagagt aggtgctcaa caaatatttc ttgaataatg aatgatgagt   2280

ttgataataa atgaaaaaga atcactatag ttgaatattt tgcacaccat tatctgattc   2340

ttataaatat agatctctat gttgctttgt gaccaatgac atttgtgttg tgaacacctg   2400

cattccttaa cagggtattg gaactgatga gtttactctg aaccgaataa tggtgtccag   2460

atcagaaatt gaccttttgg acattcgaac agagttcaag aagcattatg gctattccct   2520

atattcagca attaaatcgg atacttctgg agactatgaa atcacactct taaaaatctg   2580

tggtggagat gactgaacca agaagataat ctccaaaggt ccacgatggg ctttcccaac   2640

agctccacct tacttcttct catactattt aagagaacaa gcaaatataa acagcaactt   2700

gtgttcctaa caggaatttt cattgttcta taacaacaac aacaaaagcg attattattt   2760

tagagcatct catttataat gtagcagctc ataaatgaaa ttgaaaatgg tattaaagat   2820

ctgcaactac tatccaactt atatttctgc tttcaaagtt aagaatcttt atagttctac   2880

tccattaaat ataaagcaag ataataaaaa ttgttgcttt tgttaaaagt aa           2932


<210>  2483
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  2483

Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asp Ile Arg Thr Glu Phe 
1               5                   10                  15


Lys Lys His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys Ser Asp Thr 
            20                  25                  30


Ser Gly Asp Tyr Glu Ile Thr Leu Leu Lys Ile Cys Gly Gly Asp Asp 
        35                  40                  45


<210>  2484
<211>  792
<212>  DNA
<213>  Homo sapiens

<400>  2484
ttttcagttc tgtcttcctg aggctgctgt ttctgggcat ggccagggga tcttcagact     60

ttacaaacca gttgtgcaga gccaggcatt tcaataagga acaaaatgct gagtaacaac    120

atgaagtcag agtgttgctt gccaagagct gggaggcctg ggtggtttcc caatcttaaa    180

gaagcagaag gatattaaag tgagcctccc aaaggaaaac gtggatctac ttaccaacgc    240

agaaaatgat acacacggat tcgatttagg cacgctacat tcaaatgact tggaagagca    300

ggttctctga gccaggatac taaagtccct gtttaggaaa gagccacgtt gtatgtttac    360

cctaccacaa agatacagtc atgtgcctgg gaaagattga tgccagctcc agaaaggcat    420

ccgaatggtc taagtaatgc catccatctg tcagtaatag attcagaaat gggtatgtga    480

ttcaagtctg gccaatgaga tgtatgcaga agagtgctgg gtattctgga aaattatccc    540

ttgtcattca gagatccaca ggaatccagc cttttgctcc ttgaatggga taaggaagca    600

cataatccca gttgctcttc cagtcatccc agacccacag ccctgcttta gccatcctat    660

agccatcata tattcacaag gggagagcaa ctgaggacaa cactgtggat ccttgtgaca    720

taaccaagcc agtgaaccaa tcaatacatt tatttattgt ttgagccatt gtagttgagc    780

ttacgttact gg                                                        792


<210>  2485
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  2485

Met Tyr Ala Glu Glu Cys Trp Val Phe Trp Lys Ile Ile Pro Cys His 
1               5                   10                  15


Ser Glu Ile His Arg Asn Pro Ala Phe Cys Ser Leu Asn Gly Ile Arg 
            20                  25                  30


Lys His Ile Ile Pro Val Ala Leu Pro Val Ile Pro Asp Pro Gln Pro 
        35                  40                  45


Cys Phe Ser His Pro Ile Ala Ile Ile Tyr Ser Gln Gly Glu Ser Asn 
    50                  55                  60


<210>  2486
<211>  2389
<212>  DNA
<213>  Homo sapiens

<400>  2486
ttttcagttc tgtcttcctg aggctgctgt ttctgggcat ggccagggga tcttcagact     60

ttacaaacca gttgtgcaga gccaggcatt tcaataagga acaaaatgct gagtaacaac    120

atgaagtcag agtgttgctt gccaagagct gggaggcctg ggtggtttcc caatcttaaa    180

gaagcagaag gatattaaag tgagcctccc aaaggaaaac gtggatctac ttaccaacgc    240

agaaaatgat acacacggat tcgatttagg cacgctacat tcaaatgact tggaagagca    300

ggttctctga gccaggatac taaagtccct gtttaggaaa gagccacgtt gtatgtttac    360

cctaccacaa agatacagtg ctggcagagg aaacagcagc aatgatgctc tgcgagcctg    420

actcagggcc agcagtgatg gcagcccaag aattctggag gaaagtggct ctgggaattg    480

aacagtggct cagtgatgtt ggggccacca agtctgcaat tctccctacc tgttcttcat    540

ggttgtaaga tgactgctgc aattctcggc atcatgtgca tgttaatgtc aggaggaaga    600

aaggaagagg gagcactggg atgttacatt cattttgtca ggaaaagcaa agcctttcca    660

gacagctccg aaacttgctt acctctcatt ggccagcacc atcacttgac cacttgtcca    720

ctcctagctg caaggaaagt ggcaaagtag aaggtatttg agaatgtctg ctgggttagc    780

caaaacaata gtgacttcta cacccaattt tctgggcact gcagaagtat ccttgagtcc    840

tatgtgatca gagggagagc aaacctcaat aatgaaacag attcaatttc catcacccag    900

tgagacacca tgggattaga ataaattttt aaaaaaacaa attgaaaaaa atgcattttt    960

aaaacaacaa aatcagaaag gatgaaaggt gatatttcta gcatatcagt ttgtggtggt   1020

aaattaatta ccttatacaa aggcctcagt gactttcttc tccttaccta acgaatcatc   1080

tttaaaataa gtaaaataaa gaaacaagag cagcagcaga tgcttcctaa aaagaagtta   1140

ccaaatctgt tcaccacaaa cctgagaatt caactgtgga catttggaca ccagcaatga   1200

acatgaaact cagcttatga ggcatatttg gctaaaggtc aaggtgactt aaagttcatc   1260

ataggacatc tacaatttgc aaagcaggtg actggatatg gactccttcc aagtctcatt   1320

taattggata atgcctacgt tttaagtatc agaagtgagt ctttctctat taaatgaagt   1380

cagttccact aaaacctaaa tcttgtttgg caggcactcc atgtttctta atttttattc   1440

catgctgtat attcttttag acttgatttt cacttttttt tcttttttcc tgtacattta   1500

tctttgctgt gaaacaaagt gccctgcttt gaaggacagg tttgtgggct gctggtggtg   1560

agacaacagc agtccttcca agtcttcctc ccatcactct gttagctctc cctttgtttt   1620

taattagcat tacaccagtt aattctgtta tctcttaacc ctggttctgc atcctcttct   1680

tcttttctat tccttactcc gctcctgttt tttcttgttc tgcttttcca agaaatgtct   1740

tgtctcctca tcagttgact gtcttctctt tccagaggga ccataaaggt gccagcctaa   1800

ggaacacgta aaacgtggga acagacaaac aagctgctgc ctattacaga gatagataat   1860

taactttgga ccattacatg caattcatca gcttatcttt ttcaaacttt atataagaag   1920

tcatttccca atggtaacca cttgccagct gcaactttga cgcatattat caggataggt   1980

gagattgatg ggggcccttt gaactcttcc cagggaatta tctttataat gttacagttt   2040

tctctatagc atggtcatat tgttaacatt ggttataagg tcatatggtt agtatggtta   2100

gtattggtgg ctcacagctg taataccagc actttgggag gccaaggtgg gaggatcact   2160

tgagccctgg tgttcaaaac cagctctgga aacatagcaa gaccttgtct ctacaaaaaa   2220

aaattaaata aattaaaaga ttagctgggc atggtggcac atgcctgtag tcctcactac   2280

ttgggaaact aaggtgggag gatcctttga gcttgggagg ttgaggctgc agtgagctgt   2340

ggttgtgcca tggcactcca gcctgggtga cagagtgaga gcctgtctc               2389


<210>  2487
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  2487

Met Met Leu Cys Glu Pro Asp Ser Gly Pro Ala Val Met Ala Ala Gln 
1               5                   10                  15


Glu Phe Trp Arg Lys Val Ala Leu Gly Ile Glu Gln Trp Leu Ser Asp 
            20                  25                  30


Val Gly Ala Thr Lys Ser Ala Ile Leu Pro Thr Cys Ser Ser Trp Leu 
        35                  40                  45


<210>  2488
<211>  2483
<212>  DNA
<213>  Homo sapiens

<400>  2488
ttttcagttc tgtcttcctg aggctgctgt ttctgggcat ggccagggga tcttcagact     60

ttacaaacca gttgtgcaga gccaggcatt tcaataagga acaaaatgct gagtaacaac    120

atgaagtcag agtgttgctt gccaagagct gggaggcctg ggtggtttcc caatcttaaa    180

gaagcagaag gatattaaag tgagcctccc aaaggaaaac gtggatctac ttaccaacgc    240

agaaaatgat acacacggat tcgatttagg cacgctacat tcaaatgact tggaagagca    300

ggttctctga gccaggatac taaagtccct gtttaggaaa gagccacgtt gtatgtttac    360

cctaccacaa agatacagtc atgtgcctgg gaaagattga tgccagctcc agaaaggcat    420

ccgaatggtc taagtaatgc catccatctg tcagtaatag attcagaaat ggtgctggca    480

gaggaaacag cagcaatgat gctctgcgag cctgactcag ggccagcagt gatggcagcc    540

caagaattct ggaggaaagt ggctctggga attgaacagt ggctcagtga tgttggggcc    600

accaagtctg caattctccc tacctgttct tcatggttgt aagatgactg ctgcaattct    660

cggcatcatg tgcatgttaa tgtcaggagg aagaaaggaa gagggagcac tgggatgtta    720

cattcatttt gtcaggaaaa gcaaagcctt tccagacagc tccgaaactt gcttacctct    780

cattggccag caccatcact tgaccacttg tccactccta gctgcaagga aagtggcaaa    840

gtagaaggta tttgagaatg tctgctgggt tagccaaaac aatagtgact tctacaccca    900

attttctggg cactgcagaa gtatccttga gtcctatgtg atcagaggga gagcaaacct    960

caataatgaa acagattcaa tttccatcac ccagtgagac accatgggat tagaataaat   1020

ttttaaaaaa acaaattgaa aaaaatgcat ttttaaaaca acaaaatcag aaaggatgaa   1080

aggtgatatt tctagcatat cagtttgtgg tggtaaatta attaccttat acaaaggcct   1140

cagtgacttt cttctcctta cctaacgaat catctttaaa ataagtaaaa taaagaaaca   1200

agagcagcag cagatgcttc ctaaaaagaa gttaccaaat ctgttcacca caaacctgag   1260

aattcaactg tggacatttg gacaccagca atgaacatga aactcagctt atgaggcata   1320

tttggctaaa ggtcaaggtg acttaaagtt catcatagga catctacaat ttgcaaagca   1380

ggtgactgga tatggactcc ttccaagtct catttaattg gataatgcct acgttttaag   1440

tatcagaagt gagtctttct ctattaaatg aagtcagttc cactaaaacc taaatcttgt   1500

ttggcaggca ctccatgttt cttaattttt attccatgct gtatattctt ttagacttga   1560

ttttcacttt tttttctttt ttcctgtaca tttatctttg ctgtgaaaca aagtgccctg   1620

ctttgaagga caggtttgtg ggctgctggt ggtgagacaa cagcagtcct tccaagtctt   1680

cctcccatca ctctgttagc tctccctttg tttttaatta gcattacacc agttaattct   1740

gttatctctt aaccctggtt ctgcatcctc ttcttctttt ctattcctta ctccgctcct   1800

gttttttctt gttctgcttt tccaagaaat gtcttgtctc ctcatcagtt gactgtcttc   1860

tctttccaga gggaccataa aggtgccagc ctaaggaaca cgtaaaacgt gggaacagac   1920

aaacaagctg ctgcctatta cagagataga taattaactt tggaccatta catgcaattc   1980

atcagcttat ctttttcaaa ctttatataa gaagtcattt cccaatggta accacttgcc   2040

agctgcaact ttgacgcata ttatcaggat aggtgagatt gatgggggcc ctttgaactc   2100

ttcccaggga attatcttta taatgttaca gttttctcta tagcatggtc atattgttaa   2160

cattggttat aaggtcatat ggttagtatg gttagtattg gtggctcaca gctgtaatac   2220

cagcactttg ggaggccaag gtgggaggat cacttgagcc ctggtgttca aaaccagctc   2280

tggaaacata gcaagacctt gtctctacaa aaaaaaatta aataaattaa aagattagct   2340

gggcatggtg gcacatgcct gtagtcctca ctacttggga aactaaggtg ggaggatcct   2400

ttgagcttgg gaggttgagg ctgcagtgag ctgtggttgt gccatggcac tccagcctgg   2460

gtgacagagt gagagcctgt ctc                                           2483


<210>  2489
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  2489

Met Pro Ala Pro Glu Arg His Pro Asn Gly Leu Ser Asn Ala Ile His 
1               5                   10                  15


Leu Ser Val Ile Asp Ser Glu Met Val Leu Ala Glu Glu Thr Ala Ala 
            20                  25                  30


Met Met Leu Cys Glu Pro Asp Ser Gly Pro Ala Val Met Ala Ala Gln 
        35                  40                  45


Glu Phe Trp Arg Lys Val Ala Leu Gly Ile Glu Gln Trp Leu Ser Asp 
    50                  55                  60


Val Gly Ala Thr Lys Ser Ala Ile Leu Pro Thr Cys Ser Ser Trp Leu 
65                  70                  75                  80


<210>  2490
<211>  2317
<212>  DNA
<213>  Homo sapiens

<400>  2490
ttttcagttc tgtcttcctg aggctgctgt ttctgggcat ggccagggga tcttcagact     60

ttacaaacca gttgtgcaga gccaggcatt tcaataagga acaaaatgct gagtaacaac    120

atgaagtcag agtgttgctt gccaagagct gggaggcctg ggtggtttcc caatcttaaa    180

gaagcagaag gatattaaag tgagcctccc aaaggaaaac gtggatctac ttaccaacgc    240

agaaaatgat acacacggat tcgatttagg cacgctacat tcaaatgact tggaagagca    300

ggttctctga gccaggatac taaagtccct gtttaggaaa gagccacgtt gtatgtttac    360

cctaccacaa agatacagaa ttctggagga aagtggctct gggaattgaa cagtggctca    420

gtgatgttgg ggccaccaag tctgcaattc tccctacctg ttcttcatgg ttgtaagatg    480

actgctgcaa ttctcggcat catgtgcatg ttaatgtcag gaggaagaaa ggaagaggga    540

gcactgggat gttacattca ttttgtcagg aaaagcaaag cctttccaga cagctccgaa    600

acttgcttac ctctcattgg ccagcaccat cacttgacca cttgtccact cctagctgca    660

aggaaagtgg caaagtagaa ggtatttgag aatgtctgct gggttagcca aaacaatagt    720

gacttctaca cccaattttc tgggcactgc agaagtatcc ttgagtccta tgtgatcaga    780

gggagagcaa acctcaataa tgaaacagat tcaatttcca tcacccagtg agacaccatg    840

ggattagaat aaatttttaa aaaaacaaat tgaaaaaaat gcatttttaa aacaacaaaa    900

tcagaaagga tgaaaggtga tatttctagc atatcagttt gtggtggtaa attaattacc    960

ttatacaaag gcctcagtga ctttcttctc cttacctaac gaatcatctt taaaataagt   1020

aaaataaaga aacaagagca gcagcagatg cttcctaaaa agaagttacc aaatctgttc   1080

accacaaacc tgagaattca actgtggaca tttggacacc agcaatgaac atgaaactca   1140

gcttatgagg catatttggc taaaggtcaa ggtgacttaa agttcatcat aggacatcta   1200

caatttgcaa agcaggtgac tggatatgga ctccttccaa gtctcattta attggataat   1260

gcctacgttt taagtatcag aagtgagtct ttctctatta aatgaagtca gttccactaa   1320

aacctaaatc ttgtttggca ggcactccat gtttcttaat ttttattcca tgctgtatat   1380

tcttttagac ttgattttca cttttttttc ttttttcctg tacatttatc tttgctgtga   1440

aacaaagtgc cctgctttga aggacaggtt tgtgggctgc tggtggtgag acaacagcag   1500

tccttccaag tcttcctccc atcactctgt tagctctccc tttgttttta attagcatta   1560

caccagttaa ttctgttatc tcttaaccct ggttctgcat cctcttcttc ttttctattc   1620

cttactccgc tcctgttttt tcttgttctg cttttccaag aaatgtcttg tctcctcatc   1680

agttgactgt cttctctttc cagagggacc ataaaggtgc cagcctaagg aacacgtaaa   1740

acgtgggaac agacaaacaa gctgctgcct attacagaga tagataatta actttggacc   1800

attacatgca attcatcagc ttatcttttt caaactttat ataagaagtc atttcccaat   1860

ggtaaccact tgccagctgc aactttgacg catattatca ggataggtga gattgatggg   1920

ggccctttga actcttccca gggaattatc tttataatgt tacagttttc tctatagcat   1980

ggtcatattg ttaacattgg ttataaggtc atatggttag tatggttagt attggtggct   2040

cacagctgta ataccagcac tttgggaggc caaggtggga ggatcacttg agccctggtg   2100

ttcaaaacca gctctggaaa catagcaaga ccttgtctct acaaaaaaaa attaaataaa   2160

ttaaaagatt agctgggcat ggtggcacat gcctgtagtc ctcactactt gggaaactaa   2220

ggtgggagga tcctttgagc ttgggaggtt gaggctgcag tgagctgtgg ttgtgccatg   2280

gcactccagc ctgggtgaca gagtgagagc ctgtctc                            2317


<210>  2491
<211>  84
<212>  PRT
<213>  Homo sapiens

<400>  2491

Met Leu Gly Pro Pro Ser Leu Gln Phe Ser Leu Pro Val Leu His Gly 
1               5                   10                  15


Cys Lys Met Thr Ala Ala Ile Leu Gly Ile Met Cys Met Leu Met Ser 
            20                  25                  30


Gly Gly Arg Lys Glu Glu Gly Ala Leu Gly Cys Tyr Ile His Phe Val 
        35                  40                  45


Arg Lys Ser Lys Ala Phe Pro Asp Ser Ser Glu Thr Cys Leu Pro Leu 
    50                  55                  60


Ile Gly Gln His His His Leu Thr Thr Cys Pro Leu Leu Ala Ala Arg 
65                  70                  75                  80


Lys Val Ala Lys 



<210>  2492
<211>  2411
<212>  DNA
<213>  Homo sapiens

<400>  2492
ttttcagttc tgtcttcctg aggctgctgt ttctgggcat ggccagggga tcttcagact     60

ttacaaacca gttgtgcaga gccaggcatt tcaataagga acaaaatgct gagtaacaac    120

atgaagtcag agtgttgctt gccaagagct gggaggcctg ggtggtttcc caatcttaaa    180

gaagcagaag gatattaaag tgagcctccc aaaggaaaac gtggatctac ttaccaacgc    240

agaaaatgat acacacggat tcgatttagg cacgctacat tcaaatgact tggaagagca    300

ggttctctga gccaggatac taaagtccct gtttaggaaa gagccacgtt gtatgtttac    360

cctaccacaa agatacagtc atgtgcctgg gaaagattga tgccagctcc agaaaggcat    420

ccgaatggtc taagtaatgc catccatctg tcagtaatag attcagaaat ggaattctgg    480

aggaaagtgg ctctgggaat tgaacagtgg ctcagtgatg ttggggccac caagtctgca    540

attctcccta cctgttcttc atggttgtaa gatgactgct gcaattctcg gcatcatgtg    600

catgttaatg tcaggaggaa gaaaggaaga gggagcactg ggatgttaca ttcattttgt    660

caggaaaagc aaagcctttc cagacagctc cgaaacttgc ttacctctca ttggccagca    720

ccatcacttg accacttgtc cactcctagc tgcaaggaaa gtggcaaagt agaaggtatt    780

tgagaatgtc tgctgggtta gccaaaacaa tagtgacttc tacacccaat tttctgggca    840

ctgcagaagt atccttgagt cctatgtgat cagagggaga gcaaacctca ataatgaaac    900

agattcaatt tccatcaccc agtgagacac catgggatta gaataaattt ttaaaaaaac    960

aaattgaaaa aaatgcattt ttaaaacaac aaaatcagaa aggatgaaag gtgatatttc   1020

tagcatatca gtttgtggtg gtaaattaat taccttatac aaaggcctca gtgactttct   1080

tctccttacc taacgaatca tctttaaaat aagtaaaata aagaaacaag agcagcagca   1140

gatgcttcct aaaaagaagt taccaaatct gttcaccaca aacctgagaa ttcaactgtg   1200

gacatttgga caccagcaat gaacatgaaa ctcagcttat gaggcatatt tggctaaagg   1260

tcaaggtgac ttaaagttca tcataggaca tctacaattt gcaaagcagg tgactggata   1320

tggactcctt ccaagtctca tttaattgga taatgcctac gttttaagta tcagaagtga   1380

gtctttctct attaaatgaa gtcagttcca ctaaaaccta aatcttgttt ggcaggcact   1440

ccatgtttct taatttttat tccatgctgt atattctttt agacttgatt ttcacttttt   1500

tttctttttt cctgtacatt tatctttgct gtgaaacaaa gtgccctgct ttgaaggaca   1560

ggtttgtggg ctgctggtgg tgagacaaca gcagtccttc caagtcttcc tcccatcact   1620

ctgttagctc tccctttgtt tttaattagc attacaccag ttaattctgt tatctcttaa   1680

ccctggttct gcatcctctt cttcttttct attccttact ccgctcctgt tttttcttgt   1740

tctgcttttc caagaaatgt cttgtctcct catcagttga ctgtcttctc tttccagagg   1800

gaccataaag gtgccagcct aaggaacacg taaaacgtgg gaacagacaa acaagctgct   1860

gcctattaca gagatagata attaactttg gaccattaca tgcaattcat cagcttatct   1920

ttttcaaact ttatataaga agtcatttcc caatggtaac cacttgccag ctgcaacttt   1980

gacgcatatt atcaggatag gtgagattga tgggggccct ttgaactctt cccagggaat   2040

tatctttata atgttacagt tttctctata gcatggtcat attgttaaca ttggttataa   2100

ggtcatatgg ttagtatggt tagtattggt ggctcacagc tgtaatacca gcactttggg   2160

aggccaaggt gggaggatca cttgagccct ggtgttcaaa accagctctg gaaacatagc   2220

aagaccttgt ctctacaaaa aaaaattaaa taaattaaaa gattagctgg gcatggtggc   2280

acatgcctgt agtcctcact acttgggaaa ctaaggtggg aggatccttt gagcttggga   2340

ggttgaggct gcagtgagct gtggttgtgc catggcactc cagcctgggt gacagagtga   2400

gagcctgtct c                                                        2411


<210>  2493
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  2493

Met Pro Ala Pro Glu Arg His Pro Asn Gly Leu Ser Asn Ala Ile His 
1               5                   10                  15


Leu Ser Val Ile Asp Ser Glu Met Glu Phe Trp Arg Lys Val Ala Leu 
            20                  25                  30


Gly Ile Glu Gln Trp Leu Ser Asp Val Gly Ala Thr Lys Ser Ala Ile 
        35                  40                  45


Leu Pro Thr Cys Ser Ser Trp Leu 
    50                  55


<210>  2494
<211>  1985
<212>  DNA
<213>  Homo sapiens

<400>  2494
ttttcagttc tgtcttcctg aggctgctgt ttctgggcat ggccagggga tcttcagact     60

ttacaaacca gttgtgcaga gccaggcatt tcaataagga acaaaatgct gagtaacaac    120

atgaagtcag agtgttgctt gccaagagct gggaggcctg ggtggtttcc caatcttaaa    180

gaagcagaag gatattaaag tgagcctccc aaaggaaaac gtggatctac ttaccaacgc    240

agaaaatgat acacacggat tcgatttagg cacgctacat tcaaatgact tggaagagca    300

ggttctctga gccaggatac taaagtccct gtttaggaaa gagccacgtt gtatgtttac    360

cctaccacaa agataaaggt atttgagaat gtctgctggg ttagccaaaa caatagtgac    420

ttctacaccc aattttctgg gcactgcaga agtatccttg agtcctatgt gatcagaggg    480

agagcaaacc tcaataatga aacagattca atttccatca cccagtgaga caccatggga    540

ttagaataaa tttttaaaaa aacaaattga aaaaaatgca tttttaaaac aacaaaatca    600

gaaaggatga aaggtgatat ttctagcata tcagtttgtg gtggtaaatt aattacctta    660

tacaaaggcc tcagtgactt tcttctcctt acctaacgaa tcatctttaa aataagtaaa    720

ataaagaaac aagagcagca gcagatgctt cctaaaaaga agttaccaaa tctgttcacc    780

acaaacctga gaattcaact gtggacattt ggacaccagc aatgaacatg aaactcagct    840

tatgaggcat atttggctaa aggtcaaggt gacttaaagt tcatcatagg acatctacaa    900

tttgcaaagc aggtgactgg atatggactc cttccaagtc tcatttaatt ggataatgcc    960

tacgttttaa gtatcagaag tgagtctttc tctattaaat gaagtcagtt ccactaaaac   1020

ctaaatcttg tttggcaggc actccatgtt tcttaatttt tattccatgc tgtatattct   1080

tttagacttg attttcactt ttttttcttt tttcctgtac atttatcttt gctgtgaaac   1140

aaagtgccct gctttgaagg acaggtttgt gggctgctgg tggtgagaca acagcagtcc   1200

ttccaagtct tcctcccatc actctgttag ctctcccttt gtttttaatt agcattacac   1260

cagttaattc tgttatctct taaccctggt tctgcatcct cttcttcttt tctattcctt   1320

actccgctcc tgttttttct tgttctgctt ttccaagaaa tgtcttgtct cctcatcagt   1380

tgactgtctt ctctttccag agggaccata aaggtgccag cctaaggaac acgtaaaacg   1440

tgggaacaga caaacaagct gctgcctatt acagagatag ataattaact ttggaccatt   1500

acatgcaatt catcagctta tctttttcaa actttatata agaagtcatt tcccaatggt   1560

aaccacttgc cagctgcaac tttgacgcat attatcagga taggtgagat tgatgggggc   1620

cctttgaact cttcccaggg aattatcttt ataatgttac agttttctct atagcatggt   1680

catattgtta acattggtta taaggtcata tggttagtat ggttagtatt gtacctgtaa   1740

ggtctttggg attttgaaga tgaaaggtgt tgcataaatt gaatgaattc acttagagag   1800

atagaaggca actacaggga atattacgta catcatggag cggaaagcac taaggcctgt   1860

ggaattattc tcagtgacac gtcgttgagg gcagtggtcc acatgttttg aacatggttt   1920

ctcccaggtg aaaaggatga gtaatttgtt ctccttcaca tgtgtgtatg taggtcttat   1980

acaca                                                               1985


<210>  2495
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  2495

Met Phe Leu Asn Phe Tyr Ser Met Leu Tyr Ile Leu Leu Asp Leu Ile 
1               5                   10                  15


Phe Thr Phe Phe Ser Phe Phe Leu Tyr Ile Tyr Leu Cys Cys Glu Thr 
            20                  25                  30


Lys Cys Pro Ala Leu Lys Asp Arg Phe Val Gly Cys Trp Trp 
        35                  40                  45


<210>  2496
<211>  2111
<212>  DNA
<213>  Homo sapiens

<400>  2496
atattaaagt gagcctccca aaggaaaacg tggatctact taccaacgca gaaaatgata     60

cacacggatt cgatttagtc atgtgcctgg gaaagattga tgccagctcc agaaaggcat    120

ccgaatggtc taagtaatgc catccatctg tcagtaatag attcagaaat ggaattctgg    180

aggaaagtgg ctctgggaat tgaacagtgg ctcagtgatg ttggggccac caagtctgca    240

attctcccta cctgttcttc atggttgtaa gatgactgct gcaattctcg gcatcatgtg    300

catgttaatg tcaggaggaa gaaaggaaga gggagcactg ggatgttaca ttcattttgt    360

caggaaaagc aaagcctttc cagacagctc cgaaacttgc ttacctctca ttggccagca    420

ccatcacttg accacttgtc cactcctagc tgcaaggaaa gtggcaaagt agaaggtatt    480

tgagaatgtc tgctgggtta gccaaaacaa tagtgacttc tacacccaat tttctgggca    540

ctgcagaagt atccttgagt cctatgtgat cagagggaga gcaaacctca ataatgaaac    600

agattcaatt tccatcaccc agtgagacac catgggatta gaataaattt ttaaaaaaac    660

aaattgaaaa aaatgcattt ttaaaacaac aaaatcagaa aggatgaaag gtgatatttc    720

tagcatatca gtttgtggtg gtaaattaat taccttatac aaaggcctca gtgactttct    780

tctccttacc taacgaatca tctttaaaat aagtaaaata aagaaacaag agcagcagca    840

gatgcttcct aaaaagaagt taccaaatct gttcaccaca aacctgagaa ttcaactgtg    900

gacatttgga caccagcaat gaacatgaaa ctcagcttat gaggcatatt tggctaaagg    960

tcaaggtgac ttaaagttca tcataggaca tctacaattt gcaaagcagg tgactggata   1020

tggactcctt ccaagtctca tttaattgga taatgcctac gttttaagta tcagaagtga   1080

gtctttctct attaaatgaa gtcagttcca ctaaaaccta aatcttgttt ggcaggcact   1140

ccatgtttct taatttttat tccatgctgt atattctttt agacttgatt ttcacttttt   1200

tttctttttt cctgtacatt tatctttgct gtgaaacaaa gtgccctgct ttgaaggaca   1260

ggtttgtggg ctgctggtgg tgagacaaca gcagtccttc caagtcttcc tcccatcact   1320

ctgttagctc tccctttgtt tttaattagc attacaccag ttaattctgt tatctcttaa   1380

ccctggttct gcatcctctt cttcttttct attccttact ccgctcctgt tttttcttgt   1440

tctgcttttc caagaaatgt cttgtctcct catcagttga ctgtcttctc tttccagagg   1500

gaccataaag gtgccagcct aaggaacacg taaaacgtgg gaacagacaa acaagctgct   1560

gcctattaca gagatagata attaactttg gaccattaca tgcaattcat cagcttatct   1620

ttttcaaact ttatataaga agtcatttcc caatggtaac cacttgccag ctgcaacttt   1680

gacgcatatt atcaggatag gtgagattga tgggggccct ttgaactctt cccagggaat   1740

tatctttata atgttacagt tttctctata gcatggtcat attgttaaca ttggttataa   1800

ggtcatatgg ttagtatggt tagtattggt ggctcacagc tgtaatacca gcactttggg   1860

aggccaaggt gggaggatca cttgagccct ggtgttcaaa accagctctg gaaacatagc   1920

aagaccttgt ctctacaaaa aaaaattaaa taaattaaaa gattagctgg gcatggtggc   1980

acatgcctgt agtcctcact acttgggaaa ctaaggtggg aggatccttt gagcttggga   2040

ggttgaggct gcagtgagct gtggttgtgc catggcactc cagcctgggt gacagagtga   2100

gagcctgtct c                                                        2111


<210>  2497
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  2497

Met Pro Ala Pro Glu Arg His Pro Asn Gly Leu Ser Asn Ala Ile His 
1               5                   10                  15


Leu Ser Val Ile Asp Ser Glu Met Glu Phe Trp Arg Lys Val Ala Leu 
            20                  25                  30


Gly Ile Glu Gln Trp Leu Ser Asp Val Gly Ala Thr Lys Ser Ala Ile 
        35                  40                  45


Leu Pro Thr Cys Ser Ser Trp Leu 
    50                  55


<210>  2498
<211>  3834
<212>  DNA
<213>  Homo sapiens

<400>  2498
ggatctactt accaacgcag aaaatgatac acacggattc gatttagtca tgtgcctggg     60

aaagattgat gccagctcca gaaaggcatc cgaatggtct aaaattctgg aggaaagtgg    120

ctctgggaat tgaacagtgg ctcagtgatg ttggggccac caagtctgca attctcccta    180

cctgttcttc atggttgtaa gatgactgct gcaattctcg gcatcatgtg catgttaatg    240

tcaggaggaa gaaaggaaga gggagcactg ggatgttaca ttcattttgt caggaaaagc    300

aaagcctttc cagacagctc cgaaacttgc ttacctctca ttggccagca ccatcacttg    360

accacttgtc cactcctagc tgcaaggaaa gtggcaaagt agaaggtatt tgagaatgtc    420

tgctgggtta gccaaaacaa tagtgacttc tacacccaat tttctgggca ctgcagaagt    480

atccttgagt cctatgtgat cagagggaga gcaaacctca ataatgaaac agattcaatt    540

tccatcaccc agtgagacac catgggatta gaataaattt ttaaaaaaac aaattgaaaa    600

aaatgcattt ttaaaacaac aaaatcagaa aggatgaaag gtgatatttc tagcatatca    660

gtttgtggtg gtaaattaat taccttatac aaaggcctca gtgactttct tctccttacc    720

taacgaatca tctttaaaat aagtaaaata aagaaacaag agcagcagca gatgcttcct    780

aaaaagaagt taccaaatct gttcaccaca aacctgagaa ttcaactgtg gacatttgga    840

caccagcaat gaacatgaaa ctcagcttat gaggcatatt tggctaaagg tcaaggtgac    900

ttaaagttca tcataggaca tctacaattt gcaaagcagg tgactggata tggactcctt    960

ccaagtctca tttaattgga taatgcctac gttttaagta tcagaagtga gtctttctct   1020

attaaatgaa gtcagttcca ctaaaaccta aatcttgttt ggcaggcact ccatgtttct   1080

taatttttat tccatgctgt atattctttt agacttgatt ttcacttttt tttctttttt   1140

cctgtacatt tatctttgct gtgaaacaaa gtgccctgct ttgaaggaca ggtttgtggg   1200

ctgctggtgg tgagacaaca gcagtccttc caagtcttcc tcccatcact ctgttagctc   1260

tccctttgtt tttaattagc attacaccag ttaattctgt tatctcttaa ccctggttct   1320

gcatcctctt cttcttttct attccttact ccgctcctgt tttttcttgt tctgcttttc   1380

caagaaatgt cttgtctcct catcagttga ctgtcttctc tttccagagg gaccataaag   1440

gtgccagcct aaggaacacg taaaacgtgg gaacagacaa acaagctgct gcctattaca   1500

gagatagata attaactttg gaccattaca tgcaattcat cagcttatct ttttcaaact   1560

ttatataaga agtcatttcc caatggtaac cacttgccag ctgcaacttt gacgcatatt   1620

atcaggatag gtgagattga tgggggccct ttgaactctt cccagggaat tatctttata   1680

atgttacagt tttctctata gcatggtcat attgttaaca ttggttataa ggtcatatgg   1740

ttagtatggt tagtattggt ggctcacagc tgtaatacca gcactttggg aggccaaggt   1800

gggaggatca cttgagccct ggtgttcaaa accagctctg gaaacatagc aagaccttgt   1860

ctctacaaaa aaaaattaaa taaattaaaa gattagctgg gcatggtggc acatgcctgt   1920

agtcctcact acttgggaaa ctaaggtggg aggatccttt gagcttggga ggttgaggct   1980

gcagtgagct gtggttgtgc catggcactc cagcctgggt gacagagtga gagcctgtct   2040

caaaaaaaaa aaaaaaaaaa aaaaaaagta cctgtaaggt ctttgggatt ttgaagatga   2100

aaggtgttgc ataaattgaa tgaattcact tagagagata gaaggcaact acagggaata   2160

ttacgtacat catggagcgg aaagcactaa ggcctgtgga attattctca gtgacacgtc   2220

gttgagggca gtggtccaca tgttttgaac atggtttctc ccaggtgaaa aggatgagta   2280

atttgttctc cttcacatgt gtgtatgtag gtcttataca cagcagattt gccacaaaac   2340

aaatgaagat tacactttgg gcccctctct cacatgagcc ccttccaaag ttctgtttgc   2400

taattttaca ttttgtaatt tcttattatt tttcttaaag aagcctcctc caattgcata   2460

aacttcaagc ctcacaaaat ttggatccat acctgagcca acatacaata caattttcca   2520

tttctaactt ttagttgtac ctagtgtttt attggaaatg atcaagtaca tgagtggtgt   2580

ctttttaaaa aatttacttt atttgcttct ctagcttcat cgttagttag gcagttaaat   2640

ctaaccattt ggaggtattt tcatataacc tccattgagg acaatttggc aatagctttt   2700

aaaattataa atatatttgt acagttataa gctgccatat ctataaaact atttgataga   2760

caaaagttga aaaccctcca agagctcatc aataaaagat taaattaatt atgatacatc   2820

catatgagca ctgagcagct gtgaaaaaaa tgaggaagta attcctgtgc tgatatggga   2880

agacttccaa gacatgttgt taagtacaga atggtgtata cagtatgcta tatagtgtgg   2940

taaaaggttt agggataagc atttatattt ataactgttt atatttacat aaagtaattc   3000

tgaaaggata caaaaaagct aacaaaagag attacctgtg gtagtgtggg gcttggggat   3060

tggatgggtg agaaacagta gtggaaatga gatattgtac agtttaaggc attatacacc   3120

tataaaaaca tgggaatgta ttacctactc aaaaagtgaa attaagagag atacaagaaa   3180

ctgtttggat gttccttccc gtttcaatgt atctatattt tttcagccct caaagttatt   3240

ataaatgtca ttataataac ttcataaagc ttcccctata atgagaatct taccattctc   3300

ctaactccaa tagcactgta atccacctct gttaggacac atcactcttc atcatgtgtg   3360

attattattt gcagatatca tcttcaaggc tcttctctat ttaccacctg ccattcttgt   3420

tctcacctct acatgacctt cacattttat ttctctcggt tttttggaca agctacattc   3480

ccttccacag agaaggcttc cctgacccct ttcacttggt tggattacct tgctattctt   3540

ttctatcttt gtacattcct tttcaaaata cttatctccc ttgttgttac ctataatgtc   3600

tgtcttcttt actcaagagt ctagacaaaa agctccacgc cagcctcggc tgtgtttgta   3660

ttgtttacgt ctgtgttcct agtgcttaat aaaataccta gcaagggtta ataagtactt   3720

gttgactgga agggaatgac ttccttccct tactagagag tgatttcctt acaggcgaga   3780

tgtgtcaacc ttctatagcc cacataaaat aaaggacaat atctcctatt ggat         3834


<210>  2499
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  2499

Met Pro Ala Pro Glu Arg His Pro Asn Gly Leu Lys Phe Trp Arg Lys 
1               5                   10                  15


Val Ala Leu Gly Ile Glu Gln Trp Leu Ser Asp Val Gly Ala Thr Lys 
            20                  25                  30


Ser Ala Ile Leu Pro Thr Cys Ser Ser Trp Leu 
        35                  40


<210>  2500
<211>  2519
<212>  DNA
<213>  Homo sapiens

<400>  2500
agccgggcag ctgcagcgga gccgcggagc gggcggcggg gcccaggctg tgcgcttggg     60

gagcgcggaa tgtgaggctt ggcgggccgc agcacgctcg gacgggccag gggcggcgac    120

ccctcgcgga cgcccggctg cgcgccgggc cggggacttg cccttgcacg ctccctgcgc    180

cctccagctc gccggcggga ccatgaagaa gttctctcgg atgcccaagt cggagtcgtc    240

cgtgggggtc cgggtgttcg cggtcggccg ccaccaggtc accctggaag agtcgctggc    300

cgaaggtgga ttctccacag ttttcctcgt gcgtactcac ggtggaatcc gatgtgcatt    360

gaagcgaatg tatgtcaata acatgccaga cctcaatgtt tgtaaaaggg aaattacaat    420

tatgaaagag ctatctggtc acaaaaatat tgtgggctat ttggactgtg ctgttaattc    480

aattagtgat aatgtatggg aagtccttat cttaatggaa tattgtcgag ctggacaggt    540

agtgaatcaa atgaataaga agctacagac gggttttaca gaaccagaag tgttacagat    600

attctgtgat acctgtgaag ctgttgcaag gttgcatcag tgtaagactc caataattca    660

ccgggatctg aaggtagaaa atattttgtt gaatgatggt gggaactatg tactttgtga    720

ctttggcagt gccactaata aatttcttaa tcctcaaaaa gatggagtta atgtagtaga    780

agaagaaatt aaaaagtata caactctgtc atacagagcc cctgaaatga tcaaccttta    840

tggagggaaa cccatcacca ccaaggctga tatctgggca ctgggatgtc tactctataa    900

actttgtttc ttcactcttc cttttggtga gagtcaggtt gctatctgtg atggcaactt    960

caccatccca gacaattctc gttactcccg taacatacat tgcttaataa ggttcatgct   1020

tgaaccagat ccggaacata gacctgatat atttcaagtg tcatattttg catttaaatt   1080

tgccaaaaag gattgtccag tctccaacat caataattct tctattcctt cagctcttcc   1140

tgaaccgatg actgctagtg aagcagctgc taggaaaagc caaataaaag ccagaataac   1200

agataccatt ggaccaacag aaacctcaat tgcaccaaga caaagaccaa aggccaactc   1260

tgctactact gccactccca gtgtgctgac cattcaaagt tcagcaacac ctgttaaagt   1320

ccttgctcct ggtgaattcg gtaaccatag accaaaaggg gcactaagac ctggaaatgg   1380

ccctgaaatt ttattgggtc agggacctcc tcagcagccg ccacagcagc atagagtact   1440

ccagcaacta cagcagggag attggagatt acagcaactc catttacagc atcgtcatcc   1500

tcactacttc aagatgctta tatgcagcag tatcaacatg caacacagca gcaacagatg   1560

cttcaacaac aatttttaat gcattcggta tatcaaccac aaccttctgc atcacagtat   1620

cctacaatga tgccgcagta tcagcaggct ttctttcaac agcagatgct agctcaacat   1680

cagccgtctc aacaacaggc atcacctgaa tatcttacct cccctcaaga gttctcacca   1740

gccttagttt cctacacttc atcacttcca gctcaggttg gaaccataat ggactcctcc   1800

tatagtgcca ataggcaatt gctgataaag aggccattgc aaatttcaca aatcagaaga   1860

acatcagcaa tccacctgat atgtcagggt ggaatccttt tggagaggat aatttctcta   1920

agttaacaga agaggaacta ttggacagag aatttgacct tctaagatca agtaagggac   1980

acttgaaggc ttattttgct tcacagtaaa ataacagctc tattattatt cagcaaggcc   2040

aaagactttt gagaatgtgt atggaaaatt ctttttgtgc atttgagggc aaaattcagg   2100

ccatcttctt atacatatac tatcaaatta tgttgtgtgc attagaaatc agttgcttga   2160

tagtagctat taaacccaat attgctgata gtatgctaat atcctaaaac ttaaatattg   2220

catatctatg aatgttaaat tcagaatatc tctaaaacat ggaaaattga tgtttcaata   2280

aaaagggaga cattttatta ttttgcctta ctaatgattt tgcagctctg tttttctgca   2340

cactcaatag aaaatattgt gggtctgaga tgccctttga aaatgcctga aagaaaacat   2400

gggctactac attatgttaa tgttttgtaa tgtcctttta atgagtggtg acataaaagg   2460

gctgctttgt tgtcctgata tggcaaaaat taaataaatt ctttttcact ttaaatcag    2519


<210>  2501
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  2501

Met Lys Lys Phe Ser Arg Met Pro Lys Ser Glu Ser Ser Val Gly Val 
1               5                   10                  15


Arg Val Phe Ala Val Gly Arg His Gln Val Thr Leu Glu Glu Ser Leu 
            20                  25                  30


Ala Glu Gly Gly Phe Ser Thr Val Phe Leu Val Arg Thr His Gly Gly 
        35                  40                  45


Ile Arg Cys Ala Leu Lys Arg Met Tyr Val Asn Asn Met Pro Asp Leu 
    50                  55                  60


Asn Val Cys Lys Arg Glu Ile Thr Ile Met Lys Glu Leu Ser Gly His 
65                  70                  75                  80


Lys Asn Ile Val Gly Tyr Leu Asp Cys Ala Val Asn Ser Ile Ser Asp 
                85                  90                  95


Asn Val Trp Glu Val Leu Ile Leu Met Glu Tyr Cys Arg Ala Gly Gln 
            100                 105                 110


Val Val Asn Gln Met Asn Lys Lys Leu Gln Thr Gly Phe Thr Glu Pro 
        115                 120                 125


Glu Val Leu Gln Ile Phe Cys Asp Thr Cys Glu Ala Val Ala Arg Leu 
    130                 135                 140


His Gln Cys Lys Thr Pro Ile Ile His Arg Asp Leu Lys Val Glu Asn 
145                 150                 155                 160


Ile Leu Leu Asn Asp Gly Gly Asn Tyr Val Leu Cys Asp Phe Gly Ser 
                165                 170                 175


Ala Thr Asn Lys Phe Leu Asn Pro Gln Lys Asp Gly Val Asn Val Val 
            180                 185                 190


Glu Glu Glu Ile Lys Lys Tyr Thr Thr Leu Ser Tyr Arg Ala Pro Glu 
        195                 200                 205


Met Ile Asn Leu Tyr Gly Gly Lys Pro Ile Thr Thr Lys Ala Asp Ile 
    210                 215                 220


Trp Ala Leu Gly Cys Leu Leu Tyr Lys Leu Cys Phe Phe Thr Leu Pro 
225                 230                 235                 240


Phe Gly Glu Ser Gln Val Ala Ile Cys Asp Gly Asn Phe Thr Ile Pro 
                245                 250                 255


Asp Asn Ser Arg Tyr Ser Arg Asn Ile His Cys Leu Ile Arg Phe Met 
            260                 265                 270


Leu Glu Pro Asp Pro Glu His Arg Pro Asp Ile Phe Gln Val Ser Tyr 
        275                 280                 285


Phe Ala Phe Lys Phe Ala Lys Lys Asp Cys Pro Val Ser Asn Ile Asn 
    290                 295                 300


Asn Ser Ser Ile Pro Ser Ala Leu Pro Glu Pro Met Thr Ala Ser Glu 
305                 310                 315                 320


Ala Ala Ala Arg Lys Ser Gln Ile Lys Ala Arg Ile Thr Asp Thr Ile 
                325                 330                 335


Gly Pro Thr Glu Thr Ser Ile Ala Pro Arg Gln Arg Pro Lys Ala Asn 
            340                 345                 350


Ser Ala Thr Thr Ala Thr Pro Ser Val Leu Thr Ile Gln Ser Ser Ala 
        355                 360                 365


Thr Pro Val Lys Val Leu Ala Pro Gly Glu Phe Gly Asn His Arg Pro 
    370                 375                 380


Lys Gly Ala Leu Arg Pro Gly Asn Gly Pro Glu Ile Leu Leu Gly Gln 
385                 390                 395                 400


Gly Pro Pro Gln Gln Pro Pro Gln Gln His Arg Val Leu Gln Gln Leu 
                405                 410                 415


Gln Gln Gly Asp Trp Arg Leu Gln Gln Leu His Leu Gln His Arg His 
            420                 425                 430


Pro His Tyr Phe Lys Met Leu Ile Cys Ser Ser Ile Asn Met Gln His 
        435                 440                 445


Ser Ser Asn Arg Cys Phe Asn Asn Asn Phe 
    450                 455


<210>  2502
<211>  1493
<212>  DNA
<213>  Homo sapiens

<400>  2502
tctaatgata tttatgcttc tttggtttac aggcactggg atgtctactc tataaacttt     60

gtttcttcac tcttcctttt ggtgagagtc aggttgctat ctgtgatggc aacttcacca    120

tcccagacaa ttctcgttac tcccgtaaca tacattgctt aataaggttc atgcttgaac    180

cagatccgga acatagacct gatatatttc aagtgtcata ttttgcattt aaatttgcca    240

aaaaggattg tccagtctcc aacatcaata attcttctat tccttcagct cttcctgaac    300

cgatgactgc tagtgaagca gctgctagga aaagccaaat aaaagccaga ataacagata    360

ccattggacc aacagaaacc tcaattgcac caagacaaag accaaaggcc aactctgcta    420

ctactgccac tcccagtgtg ctgaccattc aaagttcagc aacacctgtt aaagtccttg    480

ctcctggtga attcggtaac catagaccaa aaggtaatag agccccgcca acctcatcct    540

cttaaaggtt aatgttaata aacctttcat gatttgattt cctgacctca ggtgatcctt    600

aatattgtaa agtagataac ataatgcttt cagaaacttt ctattgatgt ctaataaatt    660

cagttggttt ctcaacaatt caattgttgt aggcaaaggg aagttactgg caatataaaa    720

gtatggtaca aaaaactcac aatttgcttt gatactataa atacaaactc ttatccctag    780

agtcatcaac taatagggtt tgaggttggg aataaagttc aacggtatgg aaaaagtcta    840

tgttatatga gaaagaaagt tgaaacacta gtcttacaaa gtttatgtct ttgtattgca    900

cctagagcct tggtgaaggg ctatcttgaa ccatccatat ggacattaca acataaaaac    960

ttacctgatt ttgagaaaaa tttactcatc taaagtatct cctaagcatt atggtacagt   1020

gtggtactta aaaaaaattt ttccccccaa agaaatgtcc gtaacatttg agtaaactta   1080

tttttctcaa ggatctggga gtataacctg aagactcacc ttaaagaaat cctgttttgc   1140

actttatttc atgataaatc tgtcgtgttt taatgttaaa atgtttttaa tgaggatacc   1200

ctaatggtta agagtgtacg ttttgagtct cacgaacctg atttgagtcc tatttctccc   1260

attttttagt aatatagctt ctaaaagtac tagtacctat cttaatagga ttattgggag   1320

gattaaatgg ctgtttaatg tgctacctga tacacggtat gcctttgata aatgttaact   1380

attaactact gttgttacta tcaagtaaag tatatgttca ggaaaggtga tgtttttatt   1440

ttttatttat ttattttttt gagatgaagt ctcactcttg tcccccaggc tgg          1493


<210>  2503
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  2503

Met Leu Glu Pro Asp Pro Glu His Arg Pro Asp Ile Phe Gln Val Ser 
1               5                   10                  15


Tyr Phe Ala Phe Lys Phe Ala Lys Lys Asp Cys Pro Val Ser Asn Ile 
            20                  25                  30


Asn Asn Ser Ser Ile Pro Ser Ala Leu Pro Glu Pro Met Thr Ala Ser 
        35                  40                  45


Glu Ala Ala Ala Arg Lys Ser Gln Ile Lys Ala Arg Ile Thr Asp Thr 
    50                  55                  60


Ile Gly Pro Thr Glu Thr Ser Ile Ala Pro Arg Gln Arg Pro Lys Ala 
65                  70                  75                  80


Asn Ser Ala Thr Thr Ala Thr Pro Ser Val Leu Thr Ile Gln Ser Ser 
                85                  90                  95


Ala Thr Pro Val Lys Val Leu Ala Pro Gly Glu Phe Gly Asn His Arg 
            100                 105                 110


Pro Lys Gly Asn Arg Ala Pro Pro Thr Ser Ser Ser 
        115                 120


<210>  2504
<211>  991
<212>  DNA
<213>  Homo sapiens

<400>  2504
gcggccgccg agctctcccc gcccggccca gcccctccgc cgcagccgcg gggcagcccc     60

gagccacggc cccggctggc gggcgggctg cgggcaggat cctggcgctc gggctctggc    120

aaggggaaag gacagaaacg gcgcatcggg agggaccctg cctcaccgct tgtatatggc    180

aaagtttctc gccgagctcc tgggctgcac gttgccgagc aagggcgcct ctcccatgtt    240

tgagtctaaa agtcattccc gagttggcct gaaatcaagc accaagcaaa agaccaccat    300

tttcagcaca ttggccagtg agaagtcctt atctgactgc aaaaagataa ttgaaccagg    360

gcacaaggag acttttgtac ttgttcaggt cacacagtaa gtgatggagc caggattaca    420

acctgccctt ccttacaacc tgctcttcct tacaacctct gacaccatat tctgaaagag    480

gaaagtatgc ctcagactcc tcccttttca gcaatgtttg acagcagtgg ttacaatcga    540

aacctctatc agtctgcaga ggacagctgt ggagggttgt attaccatga caacaacctc    600

ctctctggat ccctggaagc actcatccag cacttagtac ctaatgtgga ttactatcca    660

gatgtaggta ttcatgtttc tctgaaacac atccttggca atgagtagaa attgcagtac    720

agtaggcagg gaccatagat aatacagaat tatatctagg ttgctaagaa tttttctaac    780

aagaaattgc atattgatta tcaagtgcat tgaaatcaaa tcgagcctgg ataaggatca    840

gattttggta tactatgtgt atcaatttct tttcaggtta gttacaacat tgtagatggt    900

ctgataccat ctaaatgaag tatctgtaga gttgattcat gcatatagct tagtccttaa    960

atagaaatgt cagagaacat tggatgctcc c                                   991


<210>  2505
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  2505

Met Ala Lys Phe Leu Ala Glu Leu Leu Gly Cys Thr Leu Pro Ser Lys 
1               5                   10                  15


Gly Ala Ser Pro Met Phe Glu Ser Lys Ser His Ser Arg Val Gly Leu 
            20                  25                  30


Lys Ser Ser Thr Lys Gln Lys Thr Thr Ile Phe Ser Thr Leu Ala Ser 
        35                  40                  45


Glu Lys Ser Leu Ser Asp Cys Lys Lys Ile Ile Glu Pro Gly His Lys 
    50                  55                  60


Glu Thr Phe Val Leu Val Gln Val Thr Gln 
65                  70


<210>  2506
<211>  633
<212>  DNA
<213>  Homo sapiens

<400>  2506
gcggccgccg agctctcccc gcccggccca gcccctccgc cgcagccgcg gggcagcccc     60

gagccacggc cccggctggc gggcgggctg cgggcaggat cctggcgctc gggctctggc    120

aaggggaaag gacagaaacg gcgcatcggg agggaccctg cctcaccgct tgtatatggc    180

aaagtttctc gccgagctcc tgggctgcac gttgccgagc aagggcgcct ctcccatgtt    240

tgagtctaaa agtcattccc gagttggcct gaaatcaagc accaagcaaa agaccaccat    300

tttcagcaca ttggccagtg agaagtcctt atctgactgc aaaaagaggc tgtgttccct    360

gccacgtggg gtgagccaat gggctgaaga agcatgagga aaaggagact cgggtatggc    420

aggtggctgt gtggagagga cacttggaac agcaatggaa accttccatg tacagcagca    480

taactccagt ttgctttcca agccctctga ttgagaagcc aataggcaaa gtaagaatga    540

acctactttt atcagacact atgattcgag ccagttggct gttatttctt tttgccttga    600

gctatttcgg tgaaataata aaattgatct tat                                 633


<210>  2507
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  2507

Met Ala Lys Phe Leu Ala Glu Leu Leu Gly Cys Thr Leu Pro Ser Lys 
1               5                   10                  15


Gly Ala Ser Pro Met Phe Glu Ser Lys Ser His Ser Arg Val Gly Leu 
            20                  25                  30


Lys Ser Ser Thr Lys Gln Lys Thr Thr Ile Phe Ser Thr Leu Ala Ser 
        35                  40                  45


Glu Lys Ser Leu Ser Asp Cys Lys Lys Arg Leu Cys Ser Leu Pro Arg 
    50                  55                  60


Gly Val Ser Gln Trp Ala Glu Glu Ala 
65                  70


<210>  2508
<211>  677
<212>  DNA
<213>  Homo sapiens

<400>  2508
gcggccgccg agctctcccc gcccggccca gcccctccgc cgcagccgcg gggcagcccc     60

gagccacggc cccggctggc gggcgggctg cgggcaggat cctggcgctc gggctctggc    120

aaggggaaag gacagaaacg gcgcatcggg agggaccctg cctcaccgct tgtatatggc    180

aaagtttctc gccgagctcc tgggctgcac gttgccgagc aagggcgcct ctcccatgtt    240

tgagtctaaa agtcattccc gagttggcct gaaatcaagc accaagcaaa agtttatgta    300

ttcatcctcc tgtagcttcc tgagaagtca tgggagacca ccattttcag cacattggcc    360

agtgagaagt ccttatctga ctgcaaaaag aggctgtgtt ccctgccacg tggggtgagc    420

caatgggctg aagaagcatg aggaaaagga gactcgggta tggcaggtgg ctgtgtggag    480

aggacacttg gaacagcaat ggaaaccttc catgtacagc agcataactc cagtttgctt    540

tccaagccct ctgattgaga agccaatagg caaagtaaga atgaacctac ttttatcaga    600

cactatgatt cgagccagtt ggctgttatt tctttttgcc ttgagctatt tcggtgaaat    660

aataaaattg atcttat                                                   677


<210>  2509
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  2509

Met Ala Lys Phe Leu Ala Glu Leu Leu Gly Cys Thr Leu Pro Ser Lys 
1               5                   10                  15


Gly Ala Ser Pro Met Phe Glu Ser Lys Ser His Ser Arg Val Gly Leu 
            20                  25                  30


Lys Ser Ser Thr Lys Gln Lys Phe Met Tyr Ser Ser Ser Cys Ser Phe 
        35                  40                  45


Leu Arg Ser His Gly Arg Pro Pro Phe Ser Ala His Trp Pro Val Arg 
    50                  55                  60


Ser Pro Tyr Leu Thr Ala Lys Arg Gly Cys Val Pro Cys His Val Gly 
65                  70                  75                  80


<210>  2510
<211>  533
<212>  DNA
<213>  Homo sapiens

<400>  2510
gcggccgccg agctctcccc gcccggccca gcccctccgc cgcagccgcg gggcagcccc     60

gagccacggc cccggctggc gggcgggctg cgggcaggat cctggcgctc gggctctggc    120

aaggggaaag gacagaaacg gcgcatcggg agggaccctg cctcaccgct tgtatatggc    180

aaagtttctc gccgagctcc tgggctgcac gttgccgagc aagggcgcct ctcccatgtt    240

tgagtctaaa agtcattccc gagttggcct gaaatcaagc accaagcaaa agaccaccat    300

tttcagcaca ttggccagtg agaagtcctt atctgactgc aaaaaggaac agcaatggaa    360

accttccatg tacagcagca taactccagt ttgctttcca agccctctga ttgagaagcc    420

aataggcaaa gtaagaatga acctactttt atcagacact atgattcgag ccagttggct    480

gttatttctt tttgccttga gctatttcgg tgaaataata aaattgatct tat           533


<210>  2511
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  2511

Met Ala Lys Phe Leu Ala Glu Leu Leu Gly Cys Thr Leu Pro Ser Lys 
1               5                   10                  15


Gly Ala Ser Pro Met Phe Glu Ser Lys Ser His Ser Arg Val Gly Leu 
            20                  25                  30


Lys Ser Ser Thr Lys Gln Lys Thr Thr Ile Phe Ser Thr Leu Ala Ser 
        35                  40                  45


Glu Lys Ser Leu Ser Asp Cys Lys Lys Glu Gln Gln Trp Lys Pro Ser 
    50                  55                  60


Met Tyr Ser Ser Ile Thr Pro Val Cys Phe Pro Ser Pro Leu Ile Glu 
65                  70                  75                  80


Lys Pro Ile Gly Lys Val Arg Met Asn Leu Leu Leu Ser Asp Thr Met 
                85                  90                  95


Ile Arg Ala Ser Trp Leu Leu Phe Leu Phe Ala Leu Ser Tyr Phe Gly 
            100                 105                 110


Glu Ile Ile Lys Leu Ile 
        115


<210>  2512
<211>  504
<212>  DNA
<213>  Homo sapiens

<400>  2512
gcggccgccg agctctcccc gcccggccca gcccctccgc cgcagccgcg gggcagcccc     60

gagccacggc cccggctggc gggcgggctg cgggcaggat cctggcgctc gggctctggc    120

aaggggaaag gacagaaacg gcgcatcggg agggaccctg cctcaccgct tgtatatggc    180

aaagtttctc gccgagctcc tgggctgcac gttgccgagc aagggcgcct ctcccatgtt    240

tgagtctaaa agtcattccc gagttggcct gaaatcaagc accaagcaaa agaccaccat    300

tttcagcaca ttggccagtg agaagtcctt atctgactgc aaaaagcata ctcagaccag    360

accctggaac ggagcaggtt tttgatgaat gcctgttgaa tgatgaataa acggatgaag    420

ggaaccaaga ggctgtgttc cctgccacgt ggggtgagcc aatgggctga agaagcatga    480

ggaaaaggag actcgggtat ggca                                           504


<210>  2513
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  2513

Met Ala Lys Phe Leu Ala Glu Leu Leu Gly Cys Thr Leu Pro Ser Lys 
1               5                   10                  15


Gly Ala Ser Pro Met Phe Glu Ser Lys Ser His Ser Arg Val Gly Leu 
            20                  25                  30


Lys Ser Ser Thr Lys Gln Lys Thr Thr Ile Phe Ser Thr Leu Ala Ser 
        35                  40                  45


Glu Lys Ser Leu Ser Asp Cys Lys Lys His Thr Gln Thr Arg Pro Trp 
    50                  55                  60


Asn Gly Ala Gly Phe 
65


<210>  2514
<211>  4633
<212>  DNA
<213>  Homo sapiens

<400>  2514
accagtcctg ctggcggctc agcgcggcag gacacgtgtg cgctttcagc cgggtcgcag     60

ggcgcttatc gcggcccggc agtcggggcc acgcctcacc cccgcccgcg aaccccgacc    120

tggggaaacc cggggcgctg gggaggggcc actgcgttca gctctggcgg tccacagccc    180

gaagcgcggc ttaggaagtt cgtgtcagcg ctgcctgagc tcgtcccctg gatgtccggg    240

tctccccagg cggccacccg ccggctccca tcgtgacctc cagccgcagc gcctcccacg    300

ccggccgccg cgcgagggga gcgctcgggc gcgccgggtg tggttggggg aaggggttgt    360

gccgcgcgcg ggctgcgtgc tgtgcccact caaaaggttc cgggcgcgca ggagggaaga    420

ggcagtgccc gccactccca ctgagattga gagacgcggc aaggaggcag cctgtggagg    480

aactgggtag gatttaggaa cgcaccgtgc acatgcttgg tggtcttgtt aagtggaaac    540

tgctgcttta gagtttgttt ggaaggtccg ggtgactcat cccaacattt acatccttaa    600

ttgttaaagc gctgcctccg agcgcacgca tcctgagatc ctgagccttt ggttaagacc    660

gagctctatt aagctgaaaa gataaaaact ctccagatgt cttccagtaa tgtcgaagtt    720

tttatcccag tgtcacaagg aaacaccaat ggcttccccg cgacagcttc caatgacctg    780

aaggcattta ctgaaggagc tgtgttaagt tttcataaca tctgctatcg agtaaaactg    840

aagagtggct ttctaccttg tcgaaaacca gttgagaaag aaatattatc gaatatcaat    900

gggatcatga aacctggtct caacgccatc ctgggaccca caggtggagg caaatcttcg    960

ttattagatg tcttagctgc aaggaaagat ccaagtggat tatctggaga tgttctgata   1020

aatggagcac cgcgacctgc caatttcaaa tgtaattcag gttacgtggt acaagatgat   1080

gttgtgatgg gcactctgac ggtgagagaa aacttacagt tctcagcagc tcttcggctt   1140

gcaacaacta tgacgaatca tgaaaaaaac gaacggatta acagggtcat tcaagagtta   1200

ggtctggata aagtggcaga ctccaaggtt ggaactcagt ttatccgtgg tgtgtctgga   1260

ggagaaagaa aaaggactag tataggaatg gagcttatca ctgatccttc catcttgttc   1320

ttggatgagc ctacaactgg cttagactca agcacagcaa atgctgtcct tttgctcctg   1380

aaaaggatgt ctaagcaggg acgaacaatc atcttctcca ttcatcagcc tcgatattcc   1440

atcttcaagt tgtttgatag cctcacctta ttggcctcag gaagacttat gttccacggg   1500

cctgctcagg aggccttggg atactttgaa tcagctggtt atcactgtga ggcctataat   1560

aaccctgcag acttcttctt ggacatcatt aatggagatt ccactgctgt ggcattaaac   1620

agagaagaag actttaaagc cacagagatc atagagcctt ccaagcagga taagccactc   1680

atagaaaaat tagcggagat ttatgtcaac tcctccttct acaaagagac aaaagctgaa   1740

ttacatcaac tttccggggg tgagaagaag aagaagatca cagtcttcaa ggagatcagc   1800

tacaccacct ccttctgtca tcaactcaga tgggtttcca agcgttcatt caaaaacttg   1860

ctgggtaatc cccaggcctc tatagctcag atcattgtca cagtcgtact gggactggtt   1920

ataggtgcca tttactttgg gctaaaaaat gattctactg gaatccagaa cagagctggg   1980

gttctcttct tcctgacgac caaccagtgt ttcagcagtg tttcagccgt ggaactcttt   2040

gtggtagaga agaagctctt catacatgaa tacatcagcg gatactacag agtgtcatct   2100

tatttccttg gaaaactgtt atctgattta ttacccatga ggatgttacc aagtattata   2160

tttacctgta tagtgtactt catgttagga ttgaagccaa aggcagatgc cttcttcgtt   2220

atgatgttta cccttatgat ggtggcttat tcagccagtt ccatggcact ggccatagca   2280

gcaggtcaga gtgtggtttc tgtagcaaca cttctcatga ccatctgttt tgtgtttatg   2340

atgatttttt caggtctgtt ggtcaatctc acaaccattg catcttggct gtcatggctt   2400

cagtacttca gcattccacg atatggattt acggctttgc agcataatga atttttggga   2460

caaaacttct gcccaggact caatgcaaca ggaaacaatc cttgtaacta tgcaacatgt   2520

actggcgaag aatatttggt aaagcagggc atcgatctct caccctgggg cttgtggaag   2580

aatcacgtgg ccttggcttg tatgattgtt attttcctca caattgccta cctgaaattg   2640

ttatttctta aaaaatattc ttaaatttcc ccttaattca gtatgattta tcctcacata   2700

aaaaagaagc actttgattg aagtattcaa tcaagttttt ttgttgtttt ctgttccctt   2760

gccatcacac tgttgcacag cagcaattgt tttaaagaga tacattttta gaaatcacaa   2820

caaactgaat taaacatgaa agaacccaag acatcatgta tcgcatatta gttaatctcc   2880

tcagacagta accatgggga agaaatctgg tctaatttat taatctaaaa aaggagaatt   2940

gaattctgga aactcctgac aagttattac tgtctctggc atttgtttcc tcatctttaa   3000

aatgaatagg taggttagta gcccttcagt cttaatactt tatgatgcta tggtttgcca   3060

ttatttaata aatgacaaat gtattaatgc tatactggaa atgtaaaatt gaaaatatgt   3120

tggaaaaaag attctgtctt atagggtaaa aaaagccacc gtgatagaaa aaaaatcttt   3180

ttgataagca cattaaagtt aatagaactt actgatattc ctgtctagtg gtataatatc   3240

tcaggaatct tggctgaggg tttggaactg tgggtagagt agagggccag gagtccagta   3300

atagaattct tgcaccattt ctggaacatt ctagctctgg gaggtcacgt aaccttcttg   3360

gggtagttca gtggtttagt ggtttataat ccaggtgtgc gtcagaatca tctgaggaac   3420

tttgctaaaa tacaaaaatc tggcctaagt agctccagat ctaccttcat aaaggaatct   3480

gaccactcct ggatttggta atttccaagt tctgaaaatt ttacttagga tttaataact   3540

attaacatct gtccctacat aggttttctt tcctacttat ataccttatg ttctcttcat   3600

tctaaccttc atcagtaata gggaaatgtt ttaattttat ttttttagtt gaagggtaat   3660

gtaccaaaaa atatagttca gtgaattaaa atgaacacac atgtgcaacc atcaattcag   3720

gtcaagaaat agaagattgt agcacacaaa agcctactca gccattctcc cagtcactac   3780

ttccttcctt acccctgggt tatttttgaa atgacacttg atgtatttcc ctctgttgct   3840

gttatgagaa cattgctaca gccaagtgtt gtgtttctgt gtgcataggt tgatacttaa   3900

ttatctcccc actttttaat aaacttttaa tttggaaata attttagatt gacagaaaag   3960

ttgcaaagat agtgaggaaa gttcctgtct actctttgct cagcttccct taatgttaac   4020

attttatata gcaagatgca tttgtcaaag ctaacaagtt aacattggta caatcactgt   4080

taattaaact gcacacaata ttcagatttc accacttttc cactaatatt ctttcattgt   4140

tctaggattc aattcaggag accacatttc atctagccct cttttttaaa agtaaatact   4200

tttcagcact tacaggagtt aactgagctg gggcatcatg gtgtatagac gccctgacac   4260

tggtcatctt ggaattcatt tagtttgtca gtgggtgccc tgacattctg tcacaacatc   4320

aatttgggaa catggcatta tatttttatc tttgaacttt tttctttttg gatgacattt   4380

gattaatgcg tcatcttgga acacattatc ttttttcttg gttatgtgat caggaagatt   4440

aatcagtttt tcctgttctt ggtataattc ctgcttttca catacctgtc ccttacagtt   4500

ctctatatat acccttccct tattacacag agagaaatat ctatctatac tttttacaca   4560

aaatatactt caaaagaaac aaaacagcca caattattaa ctttttaaat aaatgagaat   4620

ttaattatat cct                                                      4633


<210>  2515
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  2515

Met Ser Ser Ser Asn Val Glu Val Phe Ile Pro Val Ser Gln Gly Asn 
1               5                   10                  15


Thr Asn Gly Phe Pro Ala Thr Ala Ser Asn Asp Leu Lys Ala Phe Thr 
            20                  25                  30


Glu Gly Ala Val Leu Ser Phe His Asn Ile Cys Tyr Arg Val Lys Leu 
        35                  40                  45


Lys Ser Gly Phe Leu Pro Cys Arg Lys Pro Val Glu Lys Glu Ile Leu 
    50                  55                  60


Ser Asn Ile Asn Gly Ile Met Lys Pro Gly Leu Asn Ala Ile Leu Gly 
65                  70                  75                  80


Pro Thr Gly Gly Gly Lys Ser Ser Leu Leu Asp Val Leu Ala Ala Arg 
                85                  90                  95


Lys Asp Pro Ser Gly Leu Ser Gly Asp Val Leu Ile Asn Gly Ala Pro 
            100                 105                 110


Arg Pro Ala Asn Phe Lys Cys Asn Ser Gly Tyr Val Val Gln Asp Asp 
        115                 120                 125


Val Val Met Gly Thr Leu Thr Val Arg Glu Asn Leu Gln Phe Ser Ala 
    130                 135                 140


Ala Leu Arg Leu Ala Thr Thr Met Thr Asn His Glu Lys Asn Glu Arg 
145                 150                 155                 160


Ile Asn Arg Val Ile Gln Glu Leu Gly Leu Asp Lys Val Ala Asp Ser 
                165                 170                 175


Lys Val Gly Thr Gln Phe Ile Arg Gly Val Ser Gly Gly Glu Arg Lys 
            180                 185                 190


Arg Thr Ser Ile Gly Met Glu Leu Ile Thr Asp Pro Ser Ile Leu Phe 
        195                 200                 205


Leu Asp Glu Pro Thr Thr Gly Leu Asp Ser Ser Thr Ala Asn Ala Val 
    210                 215                 220


Leu Leu Leu Leu Lys Arg Met Ser Lys Gln Gly Arg Thr Ile Ile Phe 
225                 230                 235                 240


Ser Ile His Gln Pro Arg Tyr Ser Ile Phe Lys Leu Phe Asp Ser Leu 
                245                 250                 255


Thr Leu Leu Ala Ser Gly Arg Leu Met Phe His Gly Pro Ala Gln Glu 
            260                 265                 270


Ala Leu Gly Tyr Phe Glu Ser Ala Gly Tyr His Cys Glu Ala Tyr Asn 
        275                 280                 285


Asn Pro Ala Asp Phe Phe Leu Asp Ile Ile Asn Gly Asp Ser Thr Ala 
    290                 295                 300


Val Ala Leu Asn Arg Glu Glu Asp Phe Lys Ala Thr Glu Ile Ile Glu 
305                 310                 315                 320


Pro Ser Lys Gln Asp Lys Pro Leu Ile Glu Lys Leu Ala Glu Ile Tyr 
                325                 330                 335


Val Asn Ser Ser Phe Tyr Lys Glu Thr Lys Ala Glu Leu His Gln Leu 
            340                 345                 350


Ser Gly Gly Glu Lys Lys Lys Lys Ile Thr Val Phe Lys Glu Ile Ser 
        355                 360                 365


Tyr Thr Thr Ser Phe Cys His Gln Leu Arg Trp Val Ser Lys Arg Ser 
    370                 375                 380


Phe Lys Asn Leu Leu Gly Asn Pro Gln Ala Ser Ile Ala Gln Ile Ile 
385                 390                 395                 400


Val Thr Val Val Leu Gly Leu Val Ile Gly Ala Ile Tyr Phe Gly Leu 
                405                 410                 415


Lys Asn Asp Ser Thr Gly Ile Gln Asn Arg Ala Gly Val Leu Phe Phe 
            420                 425                 430


Leu Thr Thr Asn Gln Cys Phe Ser Ser Val Ser Ala Val Glu Leu Phe 
        435                 440                 445


Val Val Glu Lys Lys Leu Phe Ile His Glu Tyr Ile Ser Gly Tyr Tyr 
    450                 455                 460


Arg Val Ser Ser Tyr Phe Leu Gly Lys Leu Leu Ser Asp Leu Leu Pro 
465                 470                 475                 480


Met Arg Met Leu Pro Ser Ile Ile Phe Thr Cys Ile Val Tyr Phe Met 
                485                 490                 495


Leu Gly Leu Lys Pro Lys Ala Asp Ala Phe Phe Val Met Met Phe Thr 
            500                 505                 510


Leu Met Met Val Ala Tyr Ser Ala Ser Ser Met Ala Leu Ala Ile Ala 
        515                 520                 525


Ala Gly Gln Ser Val Val Ser Val Ala Thr Leu Leu Met Thr Ile Cys 
    530                 535                 540


Phe Val Phe Met Met Ile Phe Ser Gly Leu Leu Val Asn Leu Thr Thr 
545                 550                 555                 560


Ile Ala Ser Trp Leu Ser Trp Leu Gln Tyr Phe Ser Ile Pro Arg Tyr 
                565                 570                 575


Gly Phe Thr Ala Leu Gln His Asn Glu Phe Leu Gly Gln Asn Phe Cys 
            580                 585                 590


Pro Gly Leu Asn Ala Thr Gly Asn Asn Pro Cys Asn Tyr Ala Thr Cys 
        595                 600                 605


Thr Gly Glu Glu Tyr Leu Val Lys Gln Gly Ile Asp Leu Ser Pro Trp 
    610                 615                 620


Gly Leu Trp Lys Asn His Val Ala Leu Ala Cys Met Ile Val Ile Phe 
625                 630                 635                 640


Leu Thr Ile Ala Tyr Leu Lys Leu Leu Phe Leu Lys Lys Tyr Ser 
                645                 650                 655


<210>  2516
<211>  4380
<212>  DNA
<213>  Homo sapiens

<400>  2516
agaagaggat cccacgctga ctggaaccat taggtctttt gtttgaatcc cagtgatcga     60

gaaagaaatg tggttcataa tcagctagta gtggagaaaa aaggaaccca aggagatagg    120

agagctgtta atttcactcg ggacatttcc tcgaggctag tttactcgga aagcctcaat    180

gttccctggt agctgcagga tctactttgg gggctgccaa gtttcctctc tcattctttc    240

tcctgcccca agagcaggca ggaaggaaag ttcctggact gatactcgtc tgtttagtag    300

gcgtgggtcc tggttgaagt ctgtctagga aaactcctaa gtgtagaaat cttcttcgta    360

ttaccactgt ctctgcactg agatttgggc tgctttgctt ccagcgtcac acatcataac    420

tgagaaagat aaaaactctc cagatgtctt ccagtaatgt cgaagttttt atcccagtgt    480

cacaaggaaa caccaatggc ttccccgcga cagcttccaa tgacctgaag gcatttactg    540

aaggagctgt gttaagtttt cataacatct gctatcgagt aaaactgaag agtggctttc    600

taccttgtcg aaaaccagtt gagaaagaaa tattatcgaa tatcaatggg atcatgaaac    660

ctggtctcaa cgccatcctg ggacccacag gtggaggcaa atcttcgtta ttagatgtct    720

tagctgcaag gaaagatcca agtggattat ctggagatgt tctgataaat ggagcaccgc    780

gacctgccaa tttcaaatgt aattcaggtt acgtggtaca agatgatgtt gtgatgggca    840

ctctgacggt gagagaaaac ttacagttct cagcagctct tcggcttgca acaactatga    900

cgaatcatga aaaaaacgaa cggattaaca gggtcattca agagttaggt ctggataaag    960

tggcagactc caaggttgga actcagttta tccgtggtgt gtctggagga gaaagaaaaa   1020

ggactagtat aggaatggag cttatcactg atccttccat cttgttcttg gatgagccta   1080

caactggctt agactcaagc acagcaaatg ctgtcctttt gctcctgaaa aggatgtcta   1140

agcagggacg aacaatcatc ttctccattc atcagcctcg atattccatc ttcaagttgt   1200

ttgatagcct caccttattg gcctcaggaa gacttatgtt ccacgggcct gctcaggagg   1260

ccttgggata ctttgaatca gctggttatc actgtgaggc ctataataac cctgcagact   1320

tcttcttgga catcattaat ggagattcca ctgctgtggc attaaacaga gaagaagact   1380

ttaaagccac agagatcata gagccttcca agcaggataa gccactcata gaaaaattag   1440

cggagattta tgtcaactcc tccttctaca aagagacaaa agctgaatta catcaacttt   1500

ccgggggtga gaagaagaag aagatcacag tcttcaagga gatcagctac accacctcct   1560

tctgtcatca actcagatgg gtttccaagc gttcattcaa aaacttgctg ggtaatcccc   1620

aggcctctat agctcagatc attgtcacag tcgtactggg actggttata ggtgccattt   1680

actttgggct aaaaaatgat tctactggaa tccagaacag agctggggtt ctcttcttcc   1740

tgacgaccaa ccagtgtttc agcagtgttt cagccgtgga actctttgtg gtagagaaga   1800

agctcttcat acatgaatac atcagcggat actacagagt gtcatcttat ttccttggaa   1860

aactgttatc tgatttatta cccatgagga tgttaccaag tattatattt acctgtatag   1920

tgtacttcat gttaggattg aagccaaagg cagatgcctt cttcgttatg atgtttaccc   1980

ttatgatggt ggcttattca gccagttcca tggcactggc catagcagca ggtcagagtg   2040

tggtttctgt agcaacactt ctcatgacca tctgttttgt gtttatgatg attttttcag   2100

gtctgttggt caatctcaca accattgcat cttggctgtc atggcttcag tacttcagca   2160

ttccacgata tggatttacg gctttgcagc ataatgaatt tttgggacaa aacttctgcc   2220

caggactcaa tgcaacagga aacaatcctt gtaactatgc aacatgtact ggcgaagaat   2280

atttggtaaa gcagggcatc gatctctcac cctggggctt gtggaagaat cacgtggcct   2340

tggcttgtat gattgttatt ttcctcacaa ttgcctacct gaaattgtta tttcttaaaa   2400

aatattctta aatttcccct taattcagta tgatttatcc tcacataaaa aagaagcact   2460

ttgattgaag tattcaatca agtttttttg ttgttttctg ttcccttgcc atcacactgt   2520

tgcacagcag caattgtttt aaagagatac atttttagaa atcacaacaa actgaattaa   2580

acatgaaaga acccaagaca tcatgtatcg catattagtt aatctcctca gacagtaacc   2640

atggggaaga aatctggtct aatttattaa tctaaaaaag gagaattgaa ttctggaaac   2700

tcctgacaag ttattactgt ctctggcatt tgtttcctca tctttaaaat gaataggtag   2760

gttagtagcc cttcagtctt aatactttat gatgctatgg tttgccatta tttaataaat   2820

gacaaatgta ttaatgctat actggaaatg taaaattgaa aatatgttgg aaaaaagatt   2880

ctgtcttata gggtaaaaaa agccaccgtg atagaaaaaa aatctttttg ataagcacat   2940

taaagttaat agaacttact gatattcctg tctagtggta taatatctca ggaatcttgg   3000

ctgagggttt ggaactgtgg gtagagtaga gggccaggag tccagtaata gaattcttgc   3060

accatttctg gaacattcta gctctgggag gtcacgtaac cttcttgggg tagttcagtg   3120

gtttagtggt ttataatcca ggtgtgcgtc agaatcatct gaggaacttt gctaaaatac   3180

aaaaatctgg cctaagtagc tccagatcta ccttcataaa ggaatctgac cactcctgga   3240

tttggtaatt tccaagttct gaaaatttta cttaggattt aataactatt aacatctgtc   3300

cctacatagg ttttctttcc tacttatata ccttatgttc tcttcattct aaccttcatc   3360

agtaataggg aaatgtttta attttatttt tttagttgaa gggtaatgta ccaaaaaata   3420

tagttcagtg aattaaaatg aacacacatg tgcaaccatc aattcaggtc aagaaataga   3480

agattgtagc acacaaaagc ctactcagcc attctcccag tcactacttc cttccttacc   3540

cctgggttat ttttgaaatg acacttgatg tatttccctc tgttgctgtt atgagaacat   3600

tgctacagcc aagtgttgtg tttctgtgtg cataggttga tacttaatta tctccccact   3660

ttttaataaa cttttaattt ggaaataatt ttagattgac agaaaagttg caaagatagt   3720

gaggaaagtt cctgtctact ctttgctcag cttcccttaa tgttaacatt ttatatagca   3780

agatgcattt gtcaaagcta acaagttaac attggtacaa tcactgttaa ttaaactgca   3840

cacaatattc agatttcacc acttttccac taatattctt tcattgttct aggattcaat   3900

tcaggagacc acatttcatc tagccctctt ttttaaaagt aaatactttt cagcacttac   3960

aggagttaac tgagctgggg catcatggtg tatagacgcc ctgacactgg tcatcttgga   4020

attcatttag tttgtcagtg ggtgccctga cattctgtca caacatcaat ttgggaacat   4080

ggcattatat ttttatcttt gaactttttt ctttttggat gacatttgat taatgcgtca   4140

tcttggaaca cattatcttt tttcttggtt atgtgatcag gaagattaat cagtttttcc   4200

tgttcttggt ataattcctg cttttcacat acctgtccct tacagttctc tatatatacc   4260

cttcccttat tacacagaga gaaatatcta tctatacttt ttacacaaaa tatacttcaa   4320

aagaaacaaa acagccacaa ttattaactt tttaaataaa tgagaattta attatatcct   4380


<210>  2517
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  2517

Met Ser Ser Ser Asn Val Glu Val Phe Ile Pro Val Ser Gln Gly Asn 
1               5                   10                  15


Thr Asn Gly Phe Pro Ala Thr Ala Ser Asn Asp Leu Lys Ala Phe Thr 
            20                  25                  30


Glu Gly Ala Val Leu Ser Phe His Asn Ile Cys Tyr Arg Val Lys Leu 
        35                  40                  45


Lys Ser Gly Phe Leu Pro Cys Arg Lys Pro Val Glu Lys Glu Ile Leu 
    50                  55                  60


Ser Asn Ile Asn Gly Ile Met Lys Pro Gly Leu Asn Ala Ile Leu Gly 
65                  70                  75                  80


Pro Thr Gly Gly Gly Lys Ser Ser Leu Leu Asp Val Leu Ala Ala Arg 
                85                  90                  95


Lys Asp Pro Ser Gly Leu Ser Gly Asp Val Leu Ile Asn Gly Ala Pro 
            100                 105                 110


Arg Pro Ala Asn Phe Lys Cys Asn Ser Gly Tyr Val Val Gln Asp Asp 
        115                 120                 125


Val Val Met Gly Thr Leu Thr Val Arg Glu Asn Leu Gln Phe Ser Ala 
    130                 135                 140


Ala Leu Arg Leu Ala Thr Thr Met Thr Asn His Glu Lys Asn Glu Arg 
145                 150                 155                 160


Ile Asn Arg Val Ile Gln Glu Leu Gly Leu Asp Lys Val Ala Asp Ser 
                165                 170                 175


Lys Val Gly Thr Gln Phe Ile Arg Gly Val Ser Gly Gly Glu Arg Lys 
            180                 185                 190


Arg Thr Ser Ile Gly Met Glu Leu Ile Thr Asp Pro Ser Ile Leu Phe 
        195                 200                 205


Leu Asp Glu Pro Thr Thr Gly Leu Asp Ser Ser Thr Ala Asn Ala Val 
    210                 215                 220


Leu Leu Leu Leu Lys Arg Met Ser Lys Gln Gly Arg Thr Ile Ile Phe 
225                 230                 235                 240


Ser Ile His Gln Pro Arg Tyr Ser Ile Phe Lys Leu Phe Asp Ser Leu 
                245                 250                 255


Thr Leu Leu Ala Ser Gly Arg Leu Met Phe His Gly Pro Ala Gln Glu 
            260                 265                 270


Ala Leu Gly Tyr Phe Glu Ser Ala Gly Tyr His Cys Glu Ala Tyr Asn 
        275                 280                 285


Asn Pro Ala Asp Phe Phe Leu Asp Ile Ile Asn Gly Asp Ser Thr Ala 
    290                 295                 300


Val Ala Leu Asn Arg Glu Glu Asp Phe Lys Ala Thr Glu Ile Ile Glu 
305                 310                 315                 320


Pro Ser Lys Gln Asp Lys Pro Leu Ile Glu Lys Leu Ala Glu Ile Tyr 
                325                 330                 335


Val Asn Ser Ser Phe Tyr Lys Glu Thr Lys Ala Glu Leu His Gln Leu 
            340                 345                 350


Ser Gly Gly Glu Lys Lys Lys Lys Ile Thr Val Phe Lys Glu Ile Ser 
        355                 360                 365


Tyr Thr Thr Ser Phe Cys His Gln Leu Arg Trp Val Ser Lys Arg Ser 
    370                 375                 380


Phe Lys Asn Leu Leu Gly Asn Pro Gln Ala Ser Ile Ala Gln Ile Ile 
385                 390                 395                 400


Val Thr Val Val Leu Gly Leu Val Ile Gly Ala Ile Tyr Phe Gly Leu 
                405                 410                 415


Lys Asn Asp Ser Thr Gly Ile Gln Asn Arg Ala Gly Val Leu Phe Phe 
            420                 425                 430


Leu Thr Thr Asn Gln Cys Phe Ser Ser Val Ser Ala Val Glu Leu Phe 
        435                 440                 445


Val Val Glu Lys Lys Leu Phe Ile His Glu Tyr Ile Ser Gly Tyr Tyr 
    450                 455                 460


Arg Val Ser Ser Tyr Phe Leu Gly Lys Leu Leu Ser Asp Leu Leu Pro 
465                 470                 475                 480


Met Arg Met Leu Pro Ser Ile Ile Phe Thr Cys Ile Val Tyr Phe Met 
                485                 490                 495


Leu Gly Leu Lys Pro Lys Ala Asp Ala Phe Phe Val Met Met Phe Thr 
            500                 505                 510


Leu Met Met Val Ala Tyr Ser Ala Ser Ser Met Ala Leu Ala Ile Ala 
        515                 520                 525


Ala Gly Gln Ser Val Val Ser Val Ala Thr Leu Leu Met Thr Ile Cys 
    530                 535                 540


Phe Val Phe Met Met Ile Phe Ser Gly Leu Leu Val Asn Leu Thr Thr 
545                 550                 555                 560


Ile Ala Ser Trp Leu Ser Trp Leu Gln Tyr Phe Ser Ile Pro Arg Tyr 
                565                 570                 575


Gly Phe Thr Ala Leu Gln His Asn Glu Phe Leu Gly Gln Asn Phe Cys 
            580                 585                 590


Pro Gly Leu Asn Ala Thr Gly Asn Asn Pro Cys Asn Tyr Ala Thr Cys 
        595                 600                 605


Thr Gly Glu Glu Tyr Leu Val Lys Gln Gly Ile Asp Leu Ser Pro Trp 
    610                 615                 620


Gly Leu Trp Lys Asn His Val Ala Leu Ala Cys Met Ile Val Ile Phe 
625                 630                 635                 640


Leu Thr Ile Ala Tyr Leu Lys Leu Leu Phe Leu Lys Lys Tyr Ser 
                645                 650                 655


<210>  2518
<211>  2728
<212>  DNA
<213>  Homo sapiens

<400>  2518
accagtcctg ctggcggctc agcgcggcag gacacgtgtg cgctttcagc cgggtcgcag     60

ggcgcttatc gcggcccggc agtcggggcc acgcctcacc cccgcccgcg aaccccgacc    120

tggggaaacc cggggcgctg gggaggggcc actgcgttca gctctggcgg tccacagccc    180

gaagcgcggc ttaggaagtt cgtgtcagcg ctgcctgagc tcgtcccctg gatgtccggg    240

tctccccagg cggccacccg ccggctccca tcgtgacctc cagccgcagc gcctcccacg    300

ccggccgccg cgcgagggga gcgctcgggc gcgccgggtg tggttggggg aaggggttgt    360

gccgcgcgcg ggctgcgtgc tgtgcccact caaaaggttc cgggcgcgca ggagggaaga    420

ggcagtgccc gccactccca ctgagattga gagacgcggc aaggaggcag cctgtggagg    480

aactgggtag gatttaggaa cgcaccgtgc acatgcttgg tggtcttgtt aagtggaaac    540

tgctgcttta gagtttgttt ggaaggtccg ggtgactcat cccaacattt acatccttaa    600

ttgttaaagc gctgcctccg agcgcacgca tcctgagatc ctgagccttt ggttaagacc    660

gagctctatt aagctgaaaa gataaaaact ctccagatgt cttccagtaa tgtcgaagtt    720

tttatcccag tgtcacaagg aaacaccaat ggcttccccg cgacagcttc caatgacctg    780

aaggcattta ctgaaggagc tgtgttaagt tttcataaca tctgctatcg agtaaaactg    840

aagagtggct ttctaccttg tcgaaaacca gttgagaaag aaatattatc gaatatcaat    900

gggatcatga aacctggtct caacgccatc ctgggaccca caggtggagg caaatcttcg    960

ttattagatg tcttagctgc aaggaaagat ccaagtggat tatctggaga tgttctgata   1020

aatggagcac cgcgacctgc caatttcaaa tgtaattcag gttacgtggt acaagatgat   1080

gttgtgatgg gcactctgac ggtgagagaa aacttacagt tctcagcagc tcttcggctt   1140

gcaacaacta tgacgaatca tgaaaaaaac gaacggatta acagggtcat tcaagagtta   1200

ggtctggata aagtggcaga ctccaaggtt ggaactcagt ttatccgtgg tgtgtctgga   1260

ggagaaagaa aaaggactag tataggaatg gagcttatca ctgatccttc catcttgttc   1320

ttggatgagc ctacaactgg cttagactca agcacagcaa atgctgtcct tttgctcctg   1380

aaaaggatgt ctaagcaggg acgaacaatc atcttctcca ttcatcagcc tcgatattcc   1440

atcttcaagt tgtttgatag cctcacctta ttggcctcag gaagacttat gttccacggg   1500

cctgctcagg aggccttggg atactttgaa tcagctggtt atcactgtga ggcctataat   1560

aaccctgcag acttcttctt ggacatcatt aatggagatt ccactgctgt ggcattaaac   1620

agagaagaag actttaaagc cacagagatc atagagcctt ccaagcagga taagccactc   1680

atagaaaaat tagcggagat ttatgtcaac tcctccttct acaaagagac aaaagctgaa   1740

ttacatcaac tttccggggg tgagaagaag aagaagatca cagtcttcaa ggagatcagc   1800

tacaccacct ccttctgtca tcaactcaga tgggtttcca agcgttcatt caaaaacttg   1860

ctgggtaatc cccaggcctc tatagctcag atcattgtca cagtcgtact gggactggtt   1920

ataggtgcca tttactttgg gctaaaaaat gattctactg gaatccagaa cagagctggg   1980

gttctcttct tcctgacgac caaccagtgt ttcagcagtg tttcagccgt ggaactcttt   2040

gtggtagaga agaagctctt catacatgaa tacatcagcg gatactacag agtgtcatct   2100

tatttccttg gaaaactgtt atctgattta ttacccatga ggatgttacc aagtattata   2160

tttacctgta tagtgtactt catgttagga ttgaagccaa aggcagatgc cttcttcgtt   2220

atgatgttta cccttatgat ggtggcttat tcagccagtt ccatggcact ggccatagca   2280

gcaggtcaga gtgtggtttc tgtagcaaca cttctcatga ccatctgttt tgtgtttatg   2340

atgatttttt caggtctgtt ggtcaatctc acaaccattg catcttggct gtcatggctt   2400

cagtacttca gcattccacg atatggattt acggctttgc agcataatga atttttggga   2460

caaaacttct gcccaggact caatgcaaca ggaaacaatc cttgtaacta tgcaacatgt   2520

actggcgaag aatatttggt aaagcagggc atcgatctct caccctgggg cttgtggaag   2580

aatcacgtgg ccttggcttg tatgattgtt attttcctca caattgccta cctgaaattg   2640

ttatttctta aaaaatattc ttaaatttcc ccttaattca gtatgattta tcctcacata   2700

aaaaagaagc actttgattg aagtattc                                      2728


<210>  2519
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  2519

Met Ser Ser Ser Asn Val Glu Val Phe Ile Pro Val Ser Gln Gly Asn 
1               5                   10                  15


Thr Asn Gly Phe Pro Ala Thr Ala Ser Asn Asp Leu Lys Ala Phe Thr 
            20                  25                  30


Glu Gly Ala Val Leu Ser Phe His Asn Ile Cys Tyr Arg Val Lys Leu 
        35                  40                  45


Lys Ser Gly Phe Leu Pro Cys Arg Lys Pro Val Glu Lys Glu Ile Leu 
    50                  55                  60


Ser Asn Ile Asn Gly Ile Met Lys Pro Gly Leu Asn Ala Ile Leu Gly 
65                  70                  75                  80


Pro Thr Gly Gly Gly Lys Ser Ser Leu Leu Asp Val Leu Ala Ala Arg 
                85                  90                  95


Lys Asp Pro Ser Gly Leu Ser Gly Asp Val Leu Ile Asn Gly Ala Pro 
            100                 105                 110


Arg Pro Ala Asn Phe Lys Cys Asn Ser Gly Tyr Val Val Gln Asp Asp 
        115                 120                 125


Val Val Met Gly Thr Leu Thr Val Arg Glu Asn Leu Gln Phe Ser Ala 
    130                 135                 140


Ala Leu Arg Leu Ala Thr Thr Met Thr Asn His Glu Lys Asn Glu Arg 
145                 150                 155                 160


Ile Asn Arg Val Ile Gln Glu Leu Gly Leu Asp Lys Val Ala Asp Ser 
                165                 170                 175


Lys Val Gly Thr Gln Phe Ile Arg Gly Val Ser Gly Gly Glu Arg Lys 
            180                 185                 190


Arg Thr Ser Ile Gly Met Glu Leu Ile Thr Asp Pro Ser Ile Leu Phe 
        195                 200                 205


Leu Asp Glu Pro Thr Thr Gly Leu Asp Ser Ser Thr Ala Asn Ala Val 
    210                 215                 220


Leu Leu Leu Leu Lys Arg Met Ser Lys Gln Gly Arg Thr Ile Ile Phe 
225                 230                 235                 240


Ser Ile His Gln Pro Arg Tyr Ser Ile Phe Lys Leu Phe Asp Ser Leu 
                245                 250                 255


Thr Leu Leu Ala Ser Gly Arg Leu Met Phe His Gly Pro Ala Gln Glu 
            260                 265                 270


Ala Leu Gly Tyr Phe Glu Ser Ala Gly Tyr His Cys Glu Ala Tyr Asn 
        275                 280                 285


Asn Pro Ala Asp Phe Phe Leu Asp Ile Ile Asn Gly Asp Ser Thr Ala 
    290                 295                 300


Val Ala Leu Asn Arg Glu Glu Asp Phe Lys Ala Thr Glu Ile Ile Glu 
305                 310                 315                 320


Pro Ser Lys Gln Asp Lys Pro Leu Ile Glu Lys Leu Ala Glu Ile Tyr 
                325                 330                 335


Val Asn Ser Ser Phe Tyr Lys Glu Thr Lys Ala Glu Leu His Gln Leu 
            340                 345                 350


Ser Gly Gly Glu Lys Lys Lys Lys Ile Thr Val Phe Lys Glu Ile Ser 
        355                 360                 365


Tyr Thr Thr Ser Phe Cys His Gln Leu Arg Trp Val Ser Lys Arg Ser 
    370                 375                 380


Phe Lys Asn Leu Leu Gly Asn Pro Gln Ala Ser Ile Ala Gln Ile Ile 
385                 390                 395                 400


Val Thr Val Val Leu Gly Leu Val Ile Gly Ala Ile Tyr Phe Gly Leu 
                405                 410                 415


Lys Asn Asp Ser Thr Gly Ile Gln Asn Arg Ala Gly Val Leu Phe Phe 
            420                 425                 430


Leu Thr Thr Asn Gln Cys Phe Ser Ser Val Ser Ala Val Glu Leu Phe 
        435                 440                 445


Val Val Glu Lys Lys Leu Phe Ile His Glu Tyr Ile Ser Gly Tyr Tyr 
    450                 455                 460


Arg Val Ser Ser Tyr Phe Leu Gly Lys Leu Leu Ser Asp Leu Leu Pro 
465                 470                 475                 480


Met Arg Met Leu Pro Ser Ile Ile Phe Thr Cys Ile Val Tyr Phe Met 
                485                 490                 495


Leu Gly Leu Lys Pro Lys Ala Asp Ala Phe Phe Val Met Met Phe Thr 
            500                 505                 510


Leu Met Met Val Ala Tyr Ser Ala Ser Ser Met Ala Leu Ala Ile Ala 
        515                 520                 525


Ala Gly Gln Ser Val Val Ser Val Ala Thr Leu Leu Met Thr Ile Cys 
    530                 535                 540


Phe Val Phe Met Met Ile Phe Ser Gly Leu Leu Val Asn Leu Thr Thr 
545                 550                 555                 560


Ile Ala Ser Trp Leu Ser Trp Leu Gln Tyr Phe Ser Ile Pro Arg Tyr 
                565                 570                 575


Gly Phe Thr Ala Leu Gln His Asn Glu Phe Leu Gly Gln Asn Phe Cys 
            580                 585                 590


Pro Gly Leu Asn Ala Thr Gly Asn Asn Pro Cys Asn Tyr Ala Thr Cys 
        595                 600                 605


Thr Gly Glu Glu Tyr Leu Val Lys Gln Gly Ile Asp Leu Ser Pro Trp 
    610                 615                 620


Gly Leu Trp Lys Asn His Val Ala Leu Ala Cys Met Ile Val Ile Phe 
625                 630                 635                 640


Leu Thr Ile Ala Tyr Leu Lys Leu Leu Phe Leu Lys Lys Tyr Ser 
                645                 650                 655


<210>  2520
<211>  1154
<212>  DNA
<213>  Homo sapiens

<400>  2520
accagtcctg ctggcggctc agcgcggcag gacacgtgtg cgctttcagc cgggtcgcag     60

ggcgcttatc gcggcccggc agtcggggcc acgcctcacc cccgcccgcg aaccccgacc    120

tggggaaacc cggggcgctg gggaggggcc actgcgttca gctctggcgg tccacagccc    180

gaagcgcggc ttaggaagtt cgtgtcagcg ctgcctgagc tcgtcccctg gatgtccggg    240

tctccccagg cggccacccg ccggctccca tcgtgacctc cagccgcagc gcctcccacg    300

ccggccgccg cgcgagggga gcgctcgggc gcgccgggtg tggttggggg aaggggttgt    360

gccgcgcgcg ggctgcgtgc tgtgcccact caaaaggttc cgggcgcgca ggagggaaga    420

ggcagtgccc gccactccca ctgagattga gagacgcggc aaggaggcag cctgtggagg    480

aactgggtag gatttaggaa cgcaccgtgc acatgcttgg tggtcttgtt aagtggaaac    540

tgctgcttta gagtttgttt ggaaggtccg ggtgactcat cccaacattt acatccttaa    600

ttgttaaagc gctgcctccg agcgcacgca tcctgagatc ctgagccttt ggttaagacc    660

gagctctatt aagctgaaaa gataaaaact ctccagatgt cttccagtaa tgtcgaagtt    720

tttatcccag tgtcacaagg aaacaccaat ggcttccccg cgacagcttc caatgacctg    780

aaggcattta ctgaaggagc tgtgttaagt tttcataaca tctgctatcg agtaaaactg    840

aagagtggct ttctaccttg tcgaaaacca gttgagaaag aaatattatc gaatatcaat    900

gggatcatga aacctggtct caacgccatc ctgggaccca caggtggagg caaatcttcg    960

ttattagatg tcttagctgc aaggaaagat ccaagtggat tatctggaga tgttctgata   1020

aatggagcac cgcgacctgc caatttcaaa tgtaattcag gttacgtggt acaagatgat   1080

gttgtgatgg gcactctgac ggtgagagaa aacttacagt tctcagcagc tcttcggctt   1140

gcaacaacta tgac                                                     1154


<210>  2521
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  2521

Met Ser Ser Ser Asn Val Glu Val Phe Ile Pro Val Ser Gln Gly Asn 
1               5                   10                  15


Thr Asn Gly Phe Pro Ala Thr Ala Ser Asn Asp Leu Lys Ala Phe Thr 
            20                  25                  30


Glu Gly Ala Val Leu Ser Phe His Asn Ile Cys Tyr Arg Val Lys Leu 
        35                  40                  45


Lys Ser Gly Phe Leu Pro Cys Arg Lys Pro Val Glu Lys Glu Ile Leu 
    50                  55                  60


Ser Asn Ile Asn Gly Ile Met Lys Pro Gly Leu Asn Ala Ile Leu Gly 
65                  70                  75                  80


Pro Thr Gly Gly Gly Lys Ser Ser Leu Leu Asp Val Leu Ala Ala Arg 
                85                  90                  95


Lys Asp Pro Ser Gly Leu Ser Gly Asp Val Leu Ile Asn Gly Ala Pro 
            100                 105                 110


Arg Pro Ala Asn Phe Lys Cys Asn Ser Gly Tyr Val Val Gln Asp Asp 
        115                 120                 125


Val Val Met Gly Thr Leu Thr Val Arg Glu Asn Leu Gln Phe Ser Ala 
    130                 135                 140


Ala Leu Arg Leu Ala Thr Thr 
145                 150


<210>  2522
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  2522
tttcgaaaat aaagttgctg tttgtgttgg agatgctgtc atcagaattc cgcggcacaa     60

agagaaagat acaaaaatat ctctctgaca tgtaactttc ccccttcttc tagccccttg    120

ctaggaatgc cagaagagga tcccacgctg actggaacca ttaggtcttt tgtttgaatc    180

ccagtgatcg agaaagaaat gtggttcata atcagctagt agtggagaaa aaaggaaccc    240

aaggagatag gagagctgtt aatttcactc gggacatttc ctcgaggcta gtttactcgg    300

aaagcctcaa tgttccctgg tagctgcagg atctactttg ggggctgcca agtttcctct    360

ctcattcttt ctcctgcccc aagagcaggc aggaaggaaa gttcctggac tgatactcgt    420

ctgtttagta ggcgtgggtc ctggttgaag tctgtctagg aaaactccta agtgtagaaa    480

tcttcttcgt attaccactg tctctgcact gagatttggg ctgctttgct tccagcgtca    540

cacatcataa ctgagcgaca gggtctcgct acatttcccg ggctgttctc aaactcctgg    600

gctcaagtga tcttcccatc tcagcctccc aaagtgttgg gattacag                 648


<210>  2523
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  2523

Met Phe Pro Gly Ser Cys Arg Ile Tyr Phe Gly Gly Cys Gln Val Ser 
1               5                   10                  15


Ser Leu Ile Leu Ser Pro Ala Pro Arg Ala Gly Arg Lys Glu Ser Ser 
            20                  25                  30


Trp Thr Asp Thr Arg Leu Phe Ser Arg Arg Gly Ser Trp Leu Lys Ser 
        35                  40                  45


Val 



<210>  2524
<211>  3266
<212>  DNA
<213>  Homo sapiens

<400>  2524
tcgttcccat cggcatctgt gactggctgc gatcgagggc ccgggcggcc ggccagccgt     60

ctcgccgagt gcggactggc cggatctgct gtcagtcagc gggaacagac ttctccctct    120

ccatctggtc aactgcggga gaaaaatttt cgagaatttc cagcaggcaa ggcagtggcc    180

gctttgactg cttgcttcgg agatccgaga cgacggagaa ggcactctta tttaccgacc    240

aagaaagctc ctcccccgtc ctccgttagc taattaaaac atttttcagg gacgtagcca    300

tccagaggga tttgcttcct aaggagaaga acttggaaac tctgttgacc ttggcttttc    360

tagaaataga taaagccttt tcgagtcatg cccgcctgtc tgctgatgca actcttctga    420

cctctgggac tactgcaaca gtagccctat tgcgagatgg tattgaactg gttgtagcca    480

gtgttgggga cagccgggct attttgtgta gaaaaggaaa acccatgaag ctgaccattg    540

accatactcc agaaagaaaa gatgaaaaag aaaggatcaa gaaatgtggt ggttttgtag    600

cttggaatag tttggggcag cctcacgtaa atggcaggct tgcaatgaca agaagtattg    660

gagatttgga ccttaagacc agtggtgtca tagcagaacc tgaaactaag aggattaagt    720

tacatcatgc tgatgacagc ttcctggtcc tcaccacaga tggaattaac ttcatggtga    780

atagtcaaga gatttgtgac tttgtcaatc agtgccatga tcccaacgaa gcagcccatg    840

cggtgactga acaggcaata cagtacggta ctgaggataa cagtactgca gtagtagtgc    900

cttttggtgc ctggggaaaa tataagaact ctgaaatcaa cttctcattc agcagaagct    960

ttgcctccag tggacgatgg gcctgattac cagctgggac ttagagtttc tgtgcaacag   1020

tttttcactg agcatgtcaa gaaactgata agatcaaaaa ggtctcctaa ctcactagat   1080

cagcgcacaa gtcagtgtaa accacttaga tagtagtttt ttcataaatg ctcatcatat   1140

ttatgttccg ctgtacatgt tcagtataaa tatatgtgta gtgaagctac tgtgagtctt   1200

taaatggaaa gagcaaatga gaagtggttt ggatacactt gatgagagat gagagtgtca   1260

cattaataat ttttaagact cttaggcagc tatgggtttc ttttgatcat ttttgttctt   1320

tattcatttg aacacgtttt tgaagttctt caaaactagt cagtttgaat tttgacagct   1380

attcaatatg tgatctccaa gtttaaaaaa atttttttcc agacttccct aatcctaaaa   1440

tgcgagtttt tatttttaat aactgtacca aggaataagt atgaaaacag ttctctgtta   1500

ccatattttg tattctggac cacttactgg tgaaagcaac catgcaaaag aaattaattt   1560

ggccaggcac agtggctcat gcctgtaatc ccagcacttt gagaggccaa ggtgggtaga   1620

tcatctgagg tcaggaattc aagaccagcc tggccaacat ggtgaaaccc tgtctctagt   1680

aaaaatccaa aaaaaaaaaa aaaaaaaaaa aaaaaattgg ctgggcgtgg tggcagacac   1740

ctgtaatccc agctactcgg gaggctgagg aaagaggaat cacttgaacc caggagatgg   1800

gggttgcagt gagctgagat catgccattg cactccagcc tgggcagcaa gagcgaaaaa   1860

ctccatctca aaaaaaaaaa aaaaaagaaa gaaaagaaat taattcagat gatgtgacat   1920

tactaaattg tatacatatt tataaatgtg tatttcagct gtctcatcag ccctcccctc   1980

catttattcc tatttttctg tagttaagaa tactgtaaaa atgtgactat tccttaatat   2040

cagaaaagaa tgcacaggct gagtcttccg gtcaaaagtt aaatactgat ggaatcaagt   2100

attttgtatg aagttctcat ttgttatctc taacgctatt ttgtgttttg catatagtat   2160

tatagtatgt gtatatcact ttttgtatag agtaagcaat tgaataattt gttaataaaa   2220

ataataccac attgactgat actgctatag acatagcttg agttttatgt ctcctttttg   2280

ctcattttct aagacttagg agaaagaata aatctaaaat gaccattaaa acattctcca   2340

tttcagcttg ctgtgtaact taggaagtat aaaactatac ttctctttat ctgcatgtaa   2400

gtttgctgtt aaaatgtgaa tttctaaatg tgtatttgga attatttccg tagtttattt   2460

ctgcaaacta tgtaaatttg ttatatgtgt gagtatgtgt acatatgtat attttagagt   2520

aatataaaat taaagggaac aatcttgcat agctctttca ccagttttaa attattgata   2580

cgttattttt aaggactctt gacaaactag gggcaatttt cttatagtgg agacccagtg   2640

attatcagca gatgaggaaa taggttaaaa attgctatat ggcaatttgt atataaagta   2700

ataggatgtg agaaaaatac tgaatcttaa gaatgacatg gaattctgtg gcagaaacaa   2760

aagaaaaagt tgatgtagta tataccttca actgtgtttt gagttgactt tttttttttt   2820

ctttaagctt tgggtaaaaa tgtatgagga gggagagggc ccaatataaa tatttacatc   2880

ttcttacctt tttggaaatg gaagaagata aatcttgagt ttttctgcct atattaatca   2940

ggaattgccc tttgaaaaaa gtgctaaata aatattttga tttttttttt caagggaagt   3000

taggtgaaag aaggaaaaac atcacaggaa agactgttaa cattctgttt gttgtctgag   3060

aggtgaggaa ccaaagggag gcaactaaag cgggaaacca tcttgctttt tctaatcagt   3120

tcttggaaca gaaatgtgga agctaccttt aggaacatgg agaatttcca aaccaacagg   3180

caaaggaaaa ctaacgcaca aaaatgacat tctgaagatg caggtttcag ccaggcgcgg   3240

tggctcaagc ctgtaatcct agcact                                        3266


<210>  2525
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  2525

Met Lys Leu Thr Ile Asp His Thr Pro Glu Arg Lys Asp Glu Lys Glu 
1               5                   10                  15


Arg Ile Lys Lys Cys Gly Gly Phe Val Ala Trp Asn Ser Leu Gly Gln 
            20                  25                  30


Pro His Val Asn Gly Arg Leu Ala Met Thr Arg Ser Ile Gly Asp Leu 
        35                  40                  45


Asp Leu Lys Thr Ser Gly Val Ile Ala Glu Pro Glu Thr Lys Arg Ile 
    50                  55                  60


Lys Leu His His Ala Asp Asp Ser Phe Leu Val Leu Thr Thr Asp Gly 
65                  70                  75                  80


Ile Asn Phe Met Val Asn Ser Gln Glu Ile Cys Asp Phe Val Asn Gln 
                85                  90                  95


Cys His Asp Pro Asn Glu Ala Ala His Ala Val Thr Glu Gln Ala Ile 
            100                 105                 110


Gln Tyr Gly Thr Glu Asp Asn Ser Thr Ala Val Val Val Pro Phe Gly 
        115                 120                 125


Ala Trp Gly Lys Tyr Lys Asn Ser Glu Ile Asn Phe Ser Phe Ser Arg 
    130                 135                 140


Ser Phe Ala Ser Ser Gly Arg Trp Ala 
145                 150


<210>  2526
<211>  3789
<212>  DNA
<213>  Homo sapiens

<400>  2526
gtcaaatagc agccgcgggg aggctcgttc ccatcggcat ctgtgactgg ctgcgatcga     60

gggcccgggc ggccggccag ccgtctcgcc gagtgcggac tggccggatc tgctgtcagt    120

cagcgggaac agacttctcc ctctccatct ggtcaactgc gggagaaaaa ttttcgagaa    180

tttccagcag gcaaggcagt ggccgctttg actgcttgct tcggagatcc gagacgacgg    240

agaaggcact cttatttacc gaccaagaaa gctcctcccc cgtcctccgt tagctaatta    300

aaacattttt cagggacgta gccatccaga gacattccat tattgttcca ttgacctttc    360

cctcatcact gagtcctttg gagctgagtt atgtcaacag ctgccttaat tactttggtc    420

agaagtggtg ggaaccaggt gagaaggaga gtgctgctaa gctcccgcct gctgcaggac    480

gacaggcggg tgacacccac gtgccacagc tccacttcag agcctaggtg ttctcggttt    540

gacccagatg gtagtgggag tccagctacc tgggacaatt ttgggatctg ggataaccgc    600

attgatgagc caattctgct gccacccagc attaagtatg gcaagccaat tcccaaaatc    660

agcttggaaa atgtggggtg cgcctcacag attggcaaac ggaaagagaa tgaagatcgg    720

tttgacttcg ctcagctgac agatgaggtc ctgtactttg cagtgtatga tggacacggt    780

ggacctgcag cagctgattt ctgtcatacc cacatggaga aatgtattat ggatttgctt    840

cctaaggaga agaacttgga aactctgttg accttggctt ttctagaaat agataaagcc    900

ttttcgagtc atgcccgcct gtctgctgat gcaactcttc tgacctctgg gactactgca    960

acagtagccc tattgcgaga tggtattgaa ctggttgtag ccagtgttgg ggacagccgg   1020

gctattttgt gtagaaaagg aaaacccatg aagctgacca ttgaccatac tccagaaaga   1080

aaagatgaaa aagaaaggat caagaaatgt ggtggttttg tagcttggaa tagtttgggg   1140

cagcctcacg taaatggcag gcttgcaatg acaagaagta ttggagattt ggaccttaag   1200

accagtggtg tcatagcaga acctgaaact aagaggatta agttacatca tgctgatgac   1260

agcttcctgg tcctcaccac agatggaatt aacttcatgg tgaatagtca agagatttgt   1320

gactttgtca atcagtgcca tgatcccaac gaagcagccc atgcggtgac tgaacaggca   1380

atacagtacg gtactgagga taacagtact gcagtagtag tgccttttgg tgcctgggga   1440

aaatataaga actctgaaat caacttctca ttcagcagaa gctttgcctc cagtggacga   1500

tgggcctgat taccagctgg gacttagagt ttctgtgcaa cagtttttca ctgagcatgt   1560

caagaaactg ataagatcaa aaaggtctcc taactcacta gatcagcgca caagtcagtg   1620

taaaccactt agatagtagt tttttcataa atgctcatca tatttatgtt ccgctgtaca   1680

tgttcagtat aaatatatgt gtagtgaagc tactgtgagt ctttaaatgg aaagagcaaa   1740

tgagaagtgg tttggataca cttgatgaga gatgagagtg tcacattaat aatttttaag   1800

actcttaggc agctatgggt ttcttttgat catttttgtt ctttattcat ttgaacacgt   1860

ttttgaagtt cttcaaaact agtcagtttg aattttgaca gctattcaat atgtgatctc   1920

caagtttaaa aaaatttttt tccagacttc cctaatccta aaatgcgagt ttttattttt   1980

aataactgta ccaaggaata agtatgaaaa cagttctctg ttaccatatt ttgtattctg   2040

gaccacttac tggtgaaagc aaccatgcaa aagaaattaa tttggccagg cacagtggct   2100

catgcctgta atcccagcac tttgagaggc caaggtgggt agatcatctg aggtcaggaa   2160

ttcaagacca gcctggccaa catggtgaaa ccctgtctct agtaaaaatc caaaaaaaaa   2220

aaaaaaaaaa aaaaaaaaat tggctgggcg tggtggcaga cacctgtaat cccagctact   2280

cgggaggctg aggaaagagg aatcacttga acccaggaga tgggggttgc agtgagctga   2340

gatcatgcca ttgcactcca gcctgggcag caagagcgaa aaactccatc tcaaaaaaaa   2400

aaaaaaaaag aaagaaaaga aattaattca gatgatgtga cattactaaa ttgtatacat   2460

atttataaat gtgtatttca gctgtctcat cagccctccc ctccatttat tcctattttt   2520

ctgtagttaa gaatactgta aaaatgtgac tattccttaa tatcagaaaa gaatgcacag   2580

gctgagtctt ccggtcaaaa gttaaatact gatggaatca agtattttgt atgaagttct   2640

catttgttat ctctaacgct attttgtgtt ttgcatatag tattatagta tgtgtatatc   2700

actttttgta tagagtaagc aattgaataa tttgttaata aaaataatac cacattgact   2760

gatactgcta tagacatagc ttgagtttta tgtctccttt ttgctcattt tctaagactt   2820

aggagaaaga ataaatctaa aatgaccatt aaaacattct ccatttcagc ttgctgtgta   2880

acttaggaag tataaaacta tacttctctt tatctgcatg taagtttgct gttaaaatgt   2940

gaatttctaa atgtgtattt ggaattattt ccgtagttta tttctgcaaa ctatgtaaat   3000

ttgttatatg tgtgagtatg tgtacatatg tatattttag agtaatataa aattaaaggg   3060

aacaatcttg catagctctt tcaccagttt taaattattg atacgttatt tttaaggact   3120

cttgacaaac taggggcaat tttcttatag tggagaccca gtgattatca gcagatgagg   3180

aaataggtta aaaattgcta tatggcaatt tgtatataaa gtaataggat gtgagaaaaa   3240

tactgaatct taagaatgac atggaattct gtggcagaaa caaaagaaaa agttgatgta   3300

gtatatacct tcaactgtgt tttgagttga cttttttttt tttctttaag ctttgggtaa   3360

aaatgtatga ggagggagag ggcccaatat aaatatttac atcttcttac ctttttggaa   3420

atggaagaag ataaatcttg agtttttctg cctatattaa tcaggaattg ccctttgaaa   3480

aaagtgctaa ataaatattt tgattttttt tttcaaggga agttaggtga aagaaggaaa   3540

aacatcacag gaaagactgt taacattctg tttgttgtct gagaggtgag gaaccaaagg   3600

gaggcaacta aagcgggaaa ccatcttgct ttttctaatc agttcttgga acagaaatgt   3660

ggaagctacc tttaggaaca tggagaattt ccaaaccaac aggcaaagga aaactaacgc   3720

acaaaaatga cattctgaag atgcaggttt cagccaggcg cggtggctca agcctgtaat   3780

cctagcact                                                           3789


<210>  2527
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  2527

Met Ser Thr Ala Ala Leu Ile Thr Leu Val Arg Ser Gly Gly Asn Gln 
1               5                   10                  15


Val Arg Arg Arg Val Leu Leu Ser Ser Arg Leu Leu Gln Asp Asp Arg 
            20                  25                  30


Arg Val Thr Pro Thr Cys His Ser Ser Thr Ser Glu Pro Arg Cys Ser 
        35                  40                  45


Arg Phe Asp Pro Asp Gly Ser Gly Ser Pro Ala Thr Trp Asp Asn Phe 
    50                  55                  60


Gly Ile Trp Asp Asn Arg Ile Asp Glu Pro Ile Leu Leu Pro Pro Ser 
65                  70                  75                  80


Ile Lys Tyr Gly Lys Pro Ile Pro Lys Ile Ser Leu Glu Asn Val Gly 
                85                  90                  95


Cys Ala Ser Gln Ile Gly Lys Arg Lys Glu Asn Glu Asp Arg Phe Asp 
            100                 105                 110


Phe Ala Gln Leu Thr Asp Glu Val Leu Tyr Phe Ala Val Tyr Asp Gly 
        115                 120                 125


His Gly Gly Pro Ala Ala Ala Asp Phe Cys His Thr His Met Glu Lys 
    130                 135                 140


Cys Ile Met Asp Leu Leu Pro Lys Glu Lys Asn Leu Glu Thr Leu Leu 
145                 150                 155                 160


Thr Leu Ala Phe Leu Glu Ile Asp Lys Ala Phe Ser Ser His Ala Arg 
                165                 170                 175


Leu Ser Ala Asp Ala Thr Leu Leu Thr Ser Gly Thr Thr Ala Thr Val 
            180                 185                 190


Ala Leu Leu Arg Asp Gly Ile Glu Leu Val Val Ala Ser Val Gly Asp 
        195                 200                 205


Ser Arg Ala Ile Leu Cys Arg Lys Gly Lys Pro Met Lys Leu Thr Ile 
    210                 215                 220


Asp His Thr Pro Glu Arg Lys Asp Glu Lys Glu Arg Ile Lys Lys Cys 
225                 230                 235                 240


Gly Gly Phe Val Ala Trp Asn Ser Leu Gly Gln Pro His Val Asn Gly 
                245                 250                 255


Arg Leu Ala Met Thr Arg Ser Ile Gly Asp Leu Asp Leu Lys Thr Ser 
            260                 265                 270


Gly Val Ile Ala Glu Pro Glu Thr Lys Arg Ile Lys Leu His His Ala 
        275                 280                 285


Asp Asp Ser Phe Leu Val Leu Thr Thr Asp Gly Ile Asn Phe Met Val 
    290                 295                 300


Asn Ser Gln Glu Ile Cys Asp Phe Val Asn Gln Cys His Asp Pro Asn 
305                 310                 315                 320


Glu Ala Ala His Ala Val Thr Glu Gln Ala Ile Gln Tyr Gly Thr Glu 
                325                 330                 335


Asp Asn Ser Thr Ala Val Val Val Pro Phe Gly Ala Trp Gly Lys Tyr 
            340                 345                 350


Lys Asn Ser Glu Ile Asn Phe Ser Phe Ser Arg Ser Phe Ala Ser Ser 
        355                 360                 365


Gly Arg Trp Ala 
    370


<210>  2528
<211>  1448
<212>  DNA
<213>  Homo sapiens

<400>  2528
catttataaa attaaaacag ttttagaagc atacaggggt agaatatgca aatggtatac     60

ccttggcatg tctcacttag cctactaact gataatatgt tcacagcata ggagtgaaaa    120

atggaagaga aaaccttcta aatccataga ctatagaaaa gtcagcttgc ctccatgggc    180

tcaagtagac ctaagtcatc ccaccatcat agccaaccta attaaatttt aatactttca    240

gtctggacac cagatatcca tgaaggtgtt gttataagtt caagtcagct ctacttgata    300

tgaatagagg ccatttgtag atagtgatgc agtgtttgcc aaataaggtt agcaaccttt    360

ccgtttgcat ggagacttgt tactgaatta aatacttgtt tctctgcatg ctgttactta    420

catagttcat ttgcatttta tttgcttagc tctagttaaa ttagaatgat atattccagc    480

attagtttat catgcttgtg ttttattttg taataaaaat tccatatcca atcatttgac    540

tgtcactaac ttgtactctt tttttcataa tacttgtagc aactcttctg acctctggga    600

ctactgcaac agtagcccta ttgcgagatg gtattgaact ggttgtagcc agtgttgggg    660

acagccgggc tattttgtgt agaaaaggaa aacccatgaa gctgaccatt gaccatactc    720

cagaaagaaa agatgaaaaa gaaaggatca agaaatgtgg tggttttgta gcttggaata    780

gtttggggca gcctcacgta aatggcaggc ttgcaatgac aagaagtatt ggagatttgg    840

accttaagac cagtggtgtc atagcagaac ctgaaactaa gaggattaag ttacatcatg    900

ctgatgacag cttcctggtc ctcaccacag atggaattaa cttcatggtg aatagtcaag    960

agatttgtga ctttgtcaat cagtgccatg atcccaacga agcagcccat gcggtgactg   1020

aacaggtgac ccagagcttc tgcctgaaaa gtcccaagga gaaggaagga aaggacagtc   1080

caggcattgt gttttagctt ttgagtgttg cagtgaattt tacacttgat tccataatat   1140

ttccaattat aaaattttta tttccccaag ttaaaatttt aatatgccaa ggaaatgtgc   1200

tttgtttatt ctttggcttt gtatatacct tgaaatgata gtaacagcaa tagtaaatta   1260

taatagtaaa ctaatattca cttgctatgt gtcagacaat attcatatgt attagctcat   1320

tactgtatgt attgtacagt atgtacagtt acatatattg taatcatcac aataacccta   1380

ttaggttgga gctattattg tcctttttca cagatgagga aaacaggtac agaggctaca   1440

gagttaat                                                            1448


<210>  2529
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  2529

Met Lys Leu Thr Ile Asp His Thr Pro Glu Arg Lys Asp Glu Lys Glu 
1               5                   10                  15


Arg Ile Lys Lys Cys Gly Gly Phe Val Ala Trp Asn Ser Leu Gly Gln 
            20                  25                  30


Pro His Val Asn Gly Arg Leu Ala Met Thr Arg Ser Ile Gly Asp Leu 
        35                  40                  45


Asp Leu Lys Thr Ser Gly Val Ile Ala Glu Pro Glu Thr Lys Arg Ile 
    50                  55                  60


Lys Leu His His Ala Asp Asp Ser Phe Leu Val Leu Thr Thr Asp Gly 
65                  70                  75                  80


Ile Asn Phe Met Val Asn Ser Gln Glu Ile Cys Asp Phe Val Asn Gln 
                85                  90                  95


Cys His Asp Pro Asn Glu Ala Ala His Ala Val Thr Glu Gln Val Thr 
            100                 105                 110


Gln Ser Phe Cys Leu Lys Ser Pro Lys Glu Lys Glu Gly Lys Asp Ser 
        115                 120                 125


Pro Gly Ile Val Phe 
    130


<210>  2530
<211>  762
<212>  DNA
<213>  Homo sapiens

<400>  2530
cccaatcagc taacacctgc acccaatcag catcacctgc acccattcag ccagcatcac     60

ctgcacccaa tcagcatcac ctgcacccaa tcagccagca acacctgcac ccagccagca    120

tcacctgcac ccaatcaatc agcatcacct gcacccaatc agccagcatc acctccactt    180

ggaagctgcc ccaacttccc ttttccacca agccaaataa tcgcccacct ctacttctgt    240

ggcatccttt gcatgctact aatcagtgtc ttcattgtcc tgaactgccc cccaacacac    300

acccagtcca tgagctgaca gttctctaaa actcctgagc cactatagtc tctagcacag    360

tatagtgtag gcttccaaaa ctggcagcaa acacttgtta attaattgca tgaagggttt    420

caagtctata gatatcccac atcgtgtgtt atagatatcc cacttcattt tatctaacag    480

atacttaggc agagtttact atgtgctggg ctctgttcaa aataagtact actatcccca    540

tttttcaagg aaaatctaaa gcatacagag gtcaatgcac ctctgctcac ccagccagat    600

aatagaggca ggattcaaat cctagaagcc tgctcttaga gacagcactc ataaccatta    660

cattgagcta cctctcacca ttgggctatc tggattctcc ctttgtgatg ttaaattatg    720

gaattaaatc aagatatctt gaagggtgtt tgctaaattg tt                       762


<210>  2531
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  2531

Met Cys Trp Ala Leu Phe Lys Ile Ser Thr Thr Ile Pro Ile Phe Gln 
1               5                   10                  15


Gly Lys Ser Lys Ala Tyr Arg Gly Gln Cys Thr Ser Ala His Pro Ala 
            20                  25                  30


Arg 



<210>  2532
<211>  968
<212>  DNA
<213>  Homo sapiens

<400>  2532
atctgctgtc agtcagcggg aacagacttc tccctctcca tctggtcaac tgcgggagaa     60

aaattttcga gaatttccag caggcaaggc agtggccgct ttgactgctt gcttcggaga    120

tccgagacga cggagaaggc actcttattt accgaccaag aaagctcctc ccccgtcctc    180

cgttagctaa ttaaaacatt tttcagggac gtagccatcc agagacattc cattattgtt    240

ccattgacct ttccctcatc actgagtcct ttggagctga gttatgtcaa cagctgcctt    300

aattactttg gtcagaagtg gtgggaacca ggtgagaagg agagtgctgc taagctcccg    360

cctgctgcag gacgacaggc gggtgacacc cacgtgccac agctccactt cagagcctag    420

gtgttctcgg tttgacccag atggtagtgg gagtccagct acctgggaca attttgggat    480

ctgggataac cgcattgatg agccaattct gctgccaccc agcattaagt atggcaagcc    540

aattcccaaa atcagcttgg aaaatgtggg gtgcgcctca cagattggca aacggaaaga    600

gaatgaagat cggtttgact tcgctcagct gacagatgag gtcctgtact ttgcagtgta    660

tgatggacac ggtggacctg cagcagctga tttctgtcat acccacatgg agaaatgtat    720

tatggatttg cttcctaagg agaagaactt ggaaactctg ttgaccttgg cttttctaga    780

aatagataaa gccttttcga gtcatgcccg cctgtctgct gatgcaactc ttctgacctc    840

tgggactact gcaacagtag ccctattgcg agatggtatt gaactggttg tagccagtgt    900

tggggacagc cgggctattt tgtgtagaaa aggaaaaccc atgaagctga ccattgacca    960

tactccag                                                             968


<210>  2533
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  2533

Met Ser Thr Ala Ala Leu Ile Thr Leu Val Arg Ser Gly Gly Asn Gln 
1               5                   10                  15


Val Arg Arg Arg Val Leu Leu Ser Ser Arg Leu Leu Gln Asp Asp Arg 
            20                  25                  30


Arg Val Thr Pro Thr Cys His Ser Ser Thr Ser Glu Pro Arg Cys Ser 
        35                  40                  45


Arg Phe Asp Pro Asp Gly Ser Gly Ser Pro Ala Thr Trp Asp Asn Phe 
    50                  55                  60


Gly Ile Trp Asp Asn Arg Ile Asp Glu Pro Ile Leu Leu Pro Pro Ser 
65                  70                  75                  80


Ile Lys Tyr Gly Lys Pro Ile Pro Lys Ile Ser Leu Glu Asn Val Gly 
                85                  90                  95


Cys Ala Ser Gln Ile Gly Lys Arg Lys Glu Asn Glu Asp Arg Phe Asp 
            100                 105                 110


Phe Ala Gln Leu Thr Asp Glu Val Leu Tyr Phe Ala Val Tyr Asp Gly 
        115                 120                 125


His Gly Gly Pro Ala Ala Ala Asp Phe Cys His Thr His Met Glu Lys 
    130                 135                 140


Cys Ile Met Asp Leu Leu Pro Lys Glu Lys Asn Leu Glu Thr Leu Leu 
145                 150                 155                 160


Thr Leu Ala Phe Leu Glu Ile Asp Lys Ala Phe Ser Ser His Ala Arg 
                165                 170                 175


Leu Ser Ala Asp Ala Thr Leu Leu Thr Ser Gly Thr Thr Ala Thr Val 
            180                 185                 190


Ala Leu Leu Arg Asp Gly Ile Glu Leu Val Val Ala Ser Val Gly Asp 
        195                 200                 205


Ser Arg Ala Ile Leu Cys Arg Lys Gly Lys Pro Met Lys Leu Thr Ile 
    210                 215                 220


Asp His Thr 
225


<210>  2534
<211>  529
<212>  DNA
<213>  Homo sapiens

<400>  2534
agaggtaaga gcctagagag tgcaattcat ttatttctgc taaccatgta tgctgttctt     60

tattggcggt cgcggaatgg agagtaaacg gagaagggtt tcccgggagg tcgaagggga    120

gacgtcggtt tccgttcccc cgccccccga gtcggcgctt ggccggcggc ctctcggagt    180

tctcagagcg tcgctttctt ccctttggag gtcgtgagca gctcgtcggg ggatttgctt    240

cctaaggaga agaacttgga aactctgttg accttggctt ttctagaaat agataaagcc    300

ttttcgagtc atgcccgcct gtctgctgat ggtttgtaat gtttgagcac aattcctggg    360

tgaaattcgt atttgcctct gtgcgtgtta tttgtggcag agaactgtgc ctggtcagca    420

gctctagacc tggagcccgt ggacactata tgcggggctt cagtggaaag agagatctgc    480

ttaattttgt cccaggtgaa ggagtccagc ggttcctatc ctggactac                529


<210>  2535
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  2535

Met Phe Glu His Asn Ser Trp Val Lys Phe Val Phe Ala Ser Val Arg 
1               5                   10                  15


Val Ile Cys Gly Arg Glu Leu Cys Leu Val Ser Ser Ser Arg Pro Gly 
            20                  25                  30


Ala Arg Gly His Tyr Met Arg Gly Phe Ser Gly Lys Arg Asp Leu Leu 
        35                  40                  45


Asn Phe Val Pro Gly Glu Gly Val Gln Arg Phe Leu Ser Trp 
    50                  55                  60


<210>  2536
<211>  2960
<212>  DNA
<213>  Homo sapiens

<400>  2536
cgtcgctccg ccgcgcagct ggaagcctgc gaagtcaaat agcagccgcg gggaggctcg     60

ttcccatcgg catctgtgac tggctgcgat cgagggcccg ggcggccggc cagccgtctc    120

gccgagtgcg gactggccgg atctgctgtc agtcagcggg aacagacttc tccctctcca    180

tctggtcaac tgcgggagaa aaattttcga gaatttccag caggcaaggc agtggccgct    240

ttgactgctt gcttcggaga tccgagacga cggagaaggc actcttattt accgaccaag    300

aaagctcctc ccccgtcctc cgttagctaa ttaaaacatt tttcagggac gtagccatcc    360

agagacattc cattattgtt ccattgacct ttccctcatc actgagtcct ttggagctga    420

gttatgtcaa cagctgcctt aattactttg gtcagaagtg gtgggaacca ggtgagaagg    480

agagtgctgc taagctcccg cctgctgcag gacgacaggc gggtgacacc cacgtgccac    540

agctccactt cagagcctag gtgttctcgg tttgacccag atggtagtgg gagtccagct    600

acctgggaca attttgggat ctgggataac cgcattgatg agccaattct gctgccaccc    660

agcattaagt atggcaagcc aattcccaaa atcagcttgg aaaatgtggg gtgcgcctca    720

cagattggca aacggaaaga gaatgaagat cggtttgact tcgctcagct gacagatgag    780

gtcctgtact ttgcagtgta tgatggacac ggtggacctg cagcagctga tttctgtcat    840

acccacatgg agaaatgtat tatggatttg cttcctaagg agaagaactt ggaaactctg    900

ttgaccttgg cttttctaga aatagataaa gccttttcga gtcatgcccg cctgtctgct    960

gatggtatgt aaaactatca cattccttgg atcctaggga gtacatgggg tgggggagga   1020

gtaaaaagga aacactttaa gtcctttggg ggaggggatt ttaatggaca attgtttgta   1080

aggatttatg tagaaatgag tttatatgaa gaatcacatt aaatgctgtt gggaactcca   1140

attaatgtta atacctcact tttaaatgaa atatattgga gaatttttca gaaagagaag   1200

ccccgaaaca gttctgatgt tgtactttag tttttaaaag attttaaaaa tgtttaatct   1260

gtttgcttat tttatggaca aaatgtccat actatgagtt ttgttttggg tttttggttt   1320

tttttttaga tggatctggt gaccaagtgc tgaaatacac tacagggtaa tcacatctag   1380

cgaggacagt cattgtccaa caagaaaaaa attgcaaata ggtcctaaat agaaaaagac   1440

aatggttaat atgcactaat ttgtataact agaaggaaaa tatttttctg tcacttctta   1500

aaaagctcaa tcttgcagct tttctctggt aactagtgat attttcagca taaggtcatg   1560

ctagctgaat ttaaaatttt gtgtactgta tgtccttaaa ttttgaaagt gaaatgtttc   1620

tggttttgac taaatttatc aaaaccattt cacgaaaatt cagcaaacgt tttctagtta   1680

gctagtccca aatcttttgc tgttaaagtt aaccctgaaa atttctgtac cagccaaatg   1740

aatgtgtgca tgtaaccttg taaatgattt gaaaatgaat catgcaataa tcttgatctg   1800

tatttggttc atccttttct taaaaaaaag aaagaaacca agtgcaccac agaaatgtca   1860

tttgcacagt cttcagttgg aatacataag gatagagatt gtttgcattt cacagcgaag   1920

gaactgaaga ttagagtggt aaaggtcagt tcagagttag ggctgggatt ttcctgacca   1980

ccagcattat ctctcttctc tcatgaggag aggagaaggt aactctgcga tggctctatt   2040

taccatcttg agattttttc ctgagctttt tttgagaacc ttactatcac actcctcagg   2100

aaagcattac agtccactct cttcagggat atgttttcca gtttgtagat catttaggcc   2160

cattttcttt tctttcattc ctttggaatt tttctttttc ctttcaactg gacccttacc   2220

tttaagaaga cagaagctga aagaggtaaa ctttatgcat aagacttagc tcttgttcca   2280

aatagttaaa acacatgaag gaaaagagga aatgaaatat tttcttatgg ttttattttt   2340

attacttcct gaattttggt atgctcttat ttcatagtaa ctgagttggc tgtgcatctg   2400

gctatgtctc acaccacaat gtttgttgac tgtagtgtcg gtggtgtgcc ccagctgttc   2460

tgtaaatagc tgcagcttac tgggcaaggt ttttggatga gaatgtccaa atttatccca   2520

ggcatgtgac caccaaccaa aaacattggc cttctcaatg ccatcagcct cttttaaaag   2580

tatctagtca atgtagatgc ttaaaccaat cggtgattga cttgatgtaa aatatgacag   2640

gactcctttt attattgaat gaagtataac tcaacagaat tttgaactta aagaatttaa   2700

ttaacttgcc tatcttaaaa gaaactttct aaagatacct ttgtcacaaa aacattaaac   2760

agttgtataa agaaattaat cacaaaaatg taattcatat gctaacttca gcagcacata   2820

cactaaaatt ggaatgatac agagatcagc atggtccttg tgcaaggatg gcacacaaat   2880

gcatgaagag ttccatattt tttattctta ctaaaatcaa ttcatttgta ataaagaaat   2940

taaaatgcat tatttaattt                                               2960


<210>  2537
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  2537

Met Ser Thr Ala Ala Leu Ile Thr Leu Val Arg Ser Gly Gly Asn Gln 
1               5                   10                  15


Val Arg Arg Arg Val Leu Leu Ser Ser Arg Leu Leu Gln Asp Asp Arg 
            20                  25                  30


Arg Val Thr Pro Thr Cys His Ser Ser Thr Ser Glu Pro Arg Cys Ser 
        35                  40                  45


Arg Phe Asp Pro Asp Gly Ser Gly Ser Pro Ala Thr Trp Asp Asn Phe 
    50                  55                  60


Gly Ile Trp Asp Asn Arg Ile Asp Glu Pro Ile Leu Leu Pro Pro Ser 
65                  70                  75                  80


Ile Lys Tyr Gly Lys Pro Ile Pro Lys Ile Ser Leu Glu Asn Val Gly 
                85                  90                  95


Cys Ala Ser Gln Ile Gly Lys Arg Lys Glu Asn Glu Asp Arg Phe Asp 
            100                 105                 110


Phe Ala Gln Leu Thr Asp Glu Val Leu Tyr Phe Ala Val Tyr Asp Gly 
        115                 120                 125


His Gly Gly Pro Ala Ala Ala Asp Phe Cys His Thr His Met Glu Lys 
    130                 135                 140


Cys Ile Met Asp Leu Leu Pro Lys Glu Lys Asn Leu Glu Thr Leu Leu 
145                 150                 155                 160


Thr Leu Ala Phe Leu Glu Ile Asp Lys Ala Phe Ser Ser His Ala Arg 
                165                 170                 175


Leu Ser Ala Asp Gly Met 
            180


<210>  2538
<211>  737
<212>  DNA
<213>  Homo sapiens

<400>  2538
gcaggcaagg cagtggccgc tttgactgct tgcttcggag atccgagacg acggagaagg     60

cactcttatt taccgaccaa gaaagctcct cccccgtcct ccgttagcta attaaaacat    120

ttttcaggga cgtagccatc cagagacatt ccattattgt tccattgacc tttccctcat    180

cactgagtcc tttggagctg agttatgtca acagctgcct taattacttt ggtcagaagt    240

ggtgggaacc aggtgagaag gagagtgctg ctaagctccc gcctgctgca ggacgacagg    300

cgggtgacac ccacgtgcca cagctccact tcagagccta ggtgttctcg gtttgaccca    360

gatggtagtg ggagtccagc tacctgggac aattttggga tctgggataa ccgcattgat    420

gagccaattc tgctgccacc cagcattaag tatggcaagc caattcccaa aatcagcttg    480

gaaaatgtgg ggtgcgcctc acagattggc aaacggaaag agaatgaaga tcggtttgac    540

ttcgctcagc tgacagatga ggtcctgtac tttgcagtgt atgatggaca cggtggacct    600

gcagcagctg atttctgtca tacccacatg gagaaatgta ttatgtatgt acaatgactt    660

tcactcctga ctttgcagtt cctatacttc ctacttaaac tttcaccctt tggctgaggc    720

ttccagcgta aacatag                                                   737


<210>  2539
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  2539

Met Ser Thr Ala Ala Leu Ile Thr Leu Val Arg Ser Gly Gly Asn Gln 
1               5                   10                  15


Val Arg Arg Arg Val Leu Leu Ser Ser Arg Leu Leu Gln Asp Asp Arg 
            20                  25                  30


Arg Val Thr Pro Thr Cys His Ser Ser Thr Ser Glu Pro Arg Cys Ser 
        35                  40                  45


Arg Phe Asp Pro Asp Gly Ser Gly Ser Pro Ala Thr Trp Asp Asn Phe 
    50                  55                  60


Gly Ile Trp Asp Asn Arg Ile Asp Glu Pro Ile Leu Leu Pro Pro Ser 
65                  70                  75                  80


Ile Lys Tyr Gly Lys Pro Ile Pro Lys Ile Ser Leu Glu Asn Val Gly 
                85                  90                  95


Cys Ala Ser Gln Ile Gly Lys Arg Lys Glu Asn Glu Asp Arg Phe Asp 
            100                 105                 110


Phe Ala Gln Leu Thr Asp Glu Val Leu Tyr Phe Ala Val Tyr Asp Gly 
        115                 120                 125


His Gly Gly Pro Ala Ala Ala Asp Phe Cys His Thr His Met Glu Lys 
    130                 135                 140


Cys Ile Met Tyr Val Gln 
145                 150


<210>  2540
<211>  563
<212>  DNA
<213>  Homo sapiens

<400>  2540
gagtcggcgc ttggccggcg gcctctcgga gttctcagag cgtcgctttc ttccctttgg     60

aggtcgtgag cagctcgtcg gggtgaggcg gggcccagct gggctgcctg cgccccgggc    120

ggcgggtttc cagcccagac tgcgctcggc cttgaatgtg gccgcaggct ggagggccag    180

cgcggcgcga ggcgggcagg gtgggtgggc tgggactgga gacccttgcc cgaggccccg    240

gaagcgagga tgctgcgggg tgggtgccgc gttgcctccc gggcgaggga aacgtggcga    300

caacgggctc ggtacgccca gagggaggtt gggaggcgga gacctggcgg cagaaggtgc    360

cgagggagcc cagctatttg cgaggcttcg caggcaggcg ggcgtgtgtt cttcccaccg    420

tgtgtcaccc tgaccacccg cctgtcaggg ccagcgagcc gaggccagga tcctgagctg    480

tacccagaca ttccattatt gttccattga cctttccctc atcactgagt cctttggagc    540

tgagttatgt caacagctgc ctt                                            563


<210>  2541
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  2541

Met Leu Arg Gly Gly Cys Arg Val Ala Ser Arg Ala Arg Glu Thr Trp 
1               5                   10                  15


Arg Gln Arg Ala Arg Tyr Ala Gln Arg Glu Val Gly Arg Arg Arg Pro 
            20                  25                  30


Gly Gly Arg Arg Cys Arg Gly Ser Pro Ala Ile Cys Glu Ala Ser Gln 
        35                  40                  45


Ala Gly Gly Arg Val Phe Phe Pro Pro Cys Val Thr Leu Thr Thr Arg 
    50                  55                  60


Leu Ser Gly Pro Ala Ser Arg Gly Gln Asp Pro Glu Leu Tyr Pro Asp 
65                  70                  75                  80


Ile Pro Leu Leu Phe His 
                85


<210>  2542
<211>  3955
<212>  DNA
<213>  Homo sapiens

<400>  2542
attcatttcc tcctacggtg gatgcggacg ccgggaggag gagagcccca gagagaggag     60

ctgggagcgg aggcgcaggc aatgctcagc cctggatgta gctgagaggc tgggagaaga    120

gacgaccgct ggagaccgag cggcgtgggg aagacctagg ggggtgggtg ggggaagcag    180

acaggagaac attcaacgag aatgaagcca tccaatggat gcaggaaaac tggaagaaat    240

ctttcctgtt ttctgctctg tatgctgcct ttatattcgg tggtcggcac ctaatgaata    300

aacgagcaaa gtttgaactg aggaagccat tagtgctctg gtctctgacc cttgcagtct    360

tcagtatatt cggtgctctt cgaactggtg cttatatggt gtacattttg atgaccaaag    420

gcctgaagca gtcagtttgt gaccagggtt tttacaatgg acctgtcagc aaattctggg    480

cttatgcatt tgtgctaagc aaagcacccg aactaggaga tacaatattc attattctga    540

ggaagcagaa gctgatcttc ctgcactggt atcaccacat cactgtgctc ctgtactctt    600

ggtactccta caaagacatg gttgccgggg gaggttggtt catgactatg aactatggcg    660

tgcacgccgt gatgtactct tactatgcct tgcgggcggc aggtttccga gtctcccgga    720

agtttgccat gttcatcacc ttgtcccaga tcactcagat gctgatgggc tgtgtggtta    780

actacctggt cttctgctgg atgcagcatg accagtgtca ctctcacttt cagaacatct    840

tctggtcctc actcatgtac ctcagctacc ttgtgctctt ctgccatttc ttctttgagg    900

cctacatcgg caaaatgagg aaaacaacga aagctgaata gtgttggaac tgaggaggaa    960

gccatagctc agggtcatca agaaaaataa tagacaaaag aaaatggcac aaggaatcac   1020

acgtggtgca gctaaaacaa aacaaaacat gagcaaacac aaaacccaag gcagcttagg   1080

gataattagg ttgatttaac ccagtaagtt tatgatcctt ttagggtgag gactcactga   1140

gtgcacctcc atctccaagc actgctgctg gaagacccca ttccctcttt atctatcaac   1200

tctaggacaa gggagaacaa aagcaagcca gaagcagagg agactaatca aaggcaaaca   1260

aaggctatta acacatagga aaaaatgtat ttactaagtg tcacatttct ctaagatgaa   1320

agatttttac tctagaaact gtgcgagcac aacacacaca atcctttcta actttatgga   1380

cactaaactg gagccaatag aaaagacaaa aatgaaagag acacagggtg tatatctaga   1440

acgataatgc ttttgcagaa actaaagcct ttttaagaaa tgccagctgc tgtagacccc   1500

atgagaaaag atgtcttaat catccttatg aaaacagatg taaacaacta tatttcaact   1560

aacttcatct tcactgcata gcctcaggct agtgagtttg ccaaaaccaa agggggtgaa   1620

tacttcccca agattcttcc tgggaggatg gaaacagtgc agcccaggtc ccatgggggc   1680

agctccatcc cagagcattt ctgatagttg aactgtaatt tctactctta agtgagatat   1740

gaagcattat ccttttgttc agttgccccg ggcttttgaa cagaagagta aatacagaat   1800

tgaaaaagat aaacactcaa ccaaacaatg tgaaaacggg ttctgtagta tttgtaaaaa   1860

ggcccggccc aggaccactg tgagctggaa aagggagaaa ggcagtggga aaagaggtga   1920

gccgaagatc aattcgacag acagatggtg tgtatgcccc tccctgtttg acttcacaca   1980

cactcataac tttccaaatg aaaccccaca gtatagcgca tattttcgat atttttgtga   2040

attccaaaag gaaatcacag ggctgttcga aatattgggg gaacactgtg tttctgcatc   2100

atctgcattt gctccccaag caatgtagag gtgtttaaag ggccctctgc tggctgagtg   2160

gcaatactac aacaaacttc aaggcaagtt tggctgaaaa cagttgacaa caaagggccc   2220

ccatacactt atccctcaaa ttttaagtga tatgaaatac ttgtcatgtc tttggccaaa   2280

tcagaagata ttcatcctgc ttcaagtcag cttcagaaat gttttaaaag ggactttagc   2340

tctggaactc aaaatcaatt tattaagagc catattcttt aaaaaaaaaa agctggataa   2400

tattctctgt aatatttcag tcctttacaa gccaaataca tgtgtcaatg tttctagtat   2460

ttcaaagaag caattatgta aagttgttca atgtgacata atagtattat aattggttaa   2520

gtagcttaat gattaggcaa actagatgaa aagattaggg gcttccacac tgcatagatt   2580

acacgcacat agccacgcat acacacacag acacacagat gtggggtaca ctgaacttca   2640

aagcccaaat gaatagaaac acattttctg gctagcagaa aaaaacaaaa caaaactgtt   2700

gtttctcttt cttgctttga gagtgtacag taaaagggat tttttcgaat tatttttata   2760

ttattttagc tttaattgtg ctgtcgttca tgaaacagag ctgctctgct tttctgtcag   2820

agatggcaag ggctttttca gcatctcgtt tatgtgtgga atttaaaaag aataaagttt   2880

tattccattc tgtgtgaatg gtttgagcag tgaacaaaga atccatgcaa accaagtcat   2940

gactggaaga aatggggagt gggggacagt gcaggggagg aaagctgtta catctatgtt   3000

aaatgattgt gagcagtcta taatgtcttg atgttggttc ataggtgaga cacaactgat   3060

ggaggaatgt attataaatt atgcaaaatc tgacatgagc tgaaaagaca ggtcctttta   3120

taagagctaa tagatgctta ggatgcaaat gttattttga gcttcgcaaa tacatgatac   3180

cgtgcaataa gccttttttc cttataacag aaaatgagaa taattaaaat gaggagaagg   3240

ccacataaca gttgacttga atttaattga aggacccatt ggaggctcat ctggttgatt   3300

taattattta attgagtgat ttattgcaga tctcttaatg caggttagaa acggaagtga   3360

gcataaacct taaaaagact ctaaatgatg cttccaaagc actttcattt tggtattagg   3420

ttcatgtttg tttgtcttta cttgtaaaat aatttggaat ttttgtttac agggtgaatg   3480

tcttaatagt tttaaaatta gctaaatata tctaaaggca tttccaatgt ttatcatggg   3540

aggaaaaaag ccacattttt tttaaaacaa aacaaaacaa aacaaaattt tggtaatata   3600

ggttcaatac actgttttta acatctcagc ttagccgctt taatcatatc aagatatgag   3660

gctggatcac tggcccatga caaatctgaa acctaccaga gaattgactg ctgcatagat   3720

aatcctgctg ccagttaaca ttccagaaaa acttgggcag gcaagttttt atagctgccc   3780

cactatgctg caatagagta tctttctatt gaagattttc cactgcatcc cgatcctact   3840

atggtgaaag cattgttctt gggctaaaaa aaaatccttt atttcataca cacatgattt   3900

catacactag gtctgagcat caagccaagt ccatgagttt gcaatgaagt tctag        3955


<210>  2543
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  2543

Met Gln Glu Asn Trp Lys Lys Ser Phe Leu Phe Ser Ala Leu Tyr Ala 
1               5                   10                  15


Ala Phe Ile Phe Gly Gly Arg His Leu Met Asn Lys Arg Ala Lys Phe 
            20                  25                  30


Glu Leu Arg Lys Pro Leu Val Leu Trp Ser Leu Thr Leu Ala Val Phe 
        35                  40                  45


Ser Ile Phe Gly Ala Leu Arg Thr Gly Ala Tyr Met Val Tyr Ile Leu 
    50                  55                  60


Met Thr Lys Gly Leu Lys Gln Ser Val Cys Asp Gln Gly Phe Tyr Asn 
65                  70                  75                  80


Gly Pro Val Ser Lys Phe Trp Ala Tyr Ala Phe Val Leu Ser Lys Ala 
                85                  90                  95


Pro Glu Leu Gly Asp Thr Ile Phe Ile Ile Leu Arg Lys Gln Lys Leu 
            100                 105                 110


Ile Phe Leu His Trp Tyr His His Ile Thr Val Leu Leu Tyr Ser Trp 
        115                 120                 125


Tyr Ser Tyr Lys Asp Met Val Ala Gly Gly Gly Trp Phe Met Thr Met 
    130                 135                 140


Asn Tyr Gly Val His Ala Val Met Tyr Ser Tyr Tyr Ala Leu Arg Ala 
145                 150                 155                 160


Ala Gly Phe Arg Val Ser Arg Lys Phe Ala Met Phe Ile Thr Leu Ser 
                165                 170                 175


Gln Ile Thr Gln Met Leu Met Gly Cys Val Val Asn Tyr Leu Val Phe 
            180                 185                 190


Cys Trp Met Gln His Asp Gln Cys His Ser His Phe Gln Asn Ile Phe 
        195                 200                 205


Trp Ser Ser Leu Met Tyr Leu Ser Tyr Leu Val Leu Phe Cys His Phe 
    210                 215                 220


Phe Phe Glu Ala Tyr Ile Gly Lys Met Arg Lys Thr Thr Lys Ala Glu 
225                 230                 235                 240


<210>  2544
<211>  4004
<212>  DNA
<213>  Homo sapiens

<400>  2544
aatcgcacga gggggaggag atttccctgt agacgagtaa aaagggtgat ggacaaacgt     60

gcgggcacta agaccgcaag gcattcattt cctcctacgg tggatgcgga cgccgggagg    120

aggagagccc cagagagagg agctgggagc ggaggcgcag agaacacgta gcgactccga    180

agatcagccc caatgaacat gtcagtgttg actttacaag aatatgaatt cgaaaagcag    240

ttcaacgaga atgaagccat ccaatggatg caggaaaact ggaagaaatc tttcctgttt    300

tctgctctgt atgctgcctt tatattcggt ggtcggcacc taatgaataa acgagcaaag    360

tttgaactga ggaagccatt agtgctctgg tctctgaccc ttgcagtctt cagtatattc    420

ggtgctcttc gaactggtgc ttatatggtg tacattttga tgaccaaagg cctgaagcag    480

tcagtttgtg accagggttt ttacaatgga cctgtcagca aattctgggc ttatgcattt    540

gtgctaagca aagcacccga actaggagat acaatattca ttattctgag gaagcagaag    600

ctgatcttcc tgcactggta tcaccacatc actgtgctcc tgtactcttg gtactcctac    660

aaagacatgg ttgccggggg aggttggttc atgactatga actatggcgt gcacgccgtg    720

atgtactctt actatgcctt gcgggcggca ggtttccgag tctcccggaa gtttgccatg    780

ttcatcacct tgtcccagat cactcagatg ctgatgggct gtgtggttaa ctacctggtc    840

ttctgctgga tgcagcatga ccagtgtcac tctcactttc agaacatctt ctggtcctca    900

ctcatgtacc tcagctacct tgtgctcttc tgccatttct tctttgaggc ctacatcggc    960

aaaatgagga aaacaacgaa agctgaatag tgttggaact gaggaggaag ccatagctca   1020

gggtcatcaa gaaaaataat agacaaaaga aaatggcaca aggaatcaca cgtggtgcag   1080

ctaaaacaaa acaaaacatg agcaaacaca aaacccaagg cagcttaggg ataattaggt   1140

tgatttaacc cagtaagttt atgatccttt tagggtgagg actcactgag tgcacctcca   1200

tctccaagca ctgctgctgg aagaccccat tccctcttta tctatcaact ctaggacaag   1260

ggagaacaaa agcaagccag aagcagagga gactaatcaa aggcaaacaa aggctattaa   1320

cacataggaa aaaatgtatt tactaagtgt cacatttctc taagatgaaa gatttttact   1380

ctagaaactg tgcgagcaca acacacacaa tcctttctaa ctttatggac actaaactgg   1440

agccaataga aaagacaaaa atgaaagaga cacagggtgt atatctagaa cgataatgct   1500

tttgcagaaa ctaaagcctt tttaagaaat gccagctgct gtagacccca tgagaaaaga   1560

tgtcttaatc atccttatga aaacagatgt aaacaactat atttcaacta acttcatctt   1620

cactgcatag cctcaggcta gtgagtttgc caaaaccaaa gggggtgaat acttccccaa   1680

gattcttcct gggaggatgg aaacagtgca gcccaggtcc catgggggca gctccatccc   1740

agagcatttc tgatagttga actgtaattt ctactcttaa gtgagatatg aagcattatc   1800

cttttgttca gttgccccgg gcttttgaac agaagagtaa atacagaatt gaaaaagata   1860

aacactcaac caaacaatgt gaaaacgggt tctgtagtat ttgtaaaaag gcccggccca   1920

ggaccactgt gagctggaaa agggagaaag gcagtgggaa aagaggtgag ccgaagatca   1980

attcgacaga cagatggtgt gtatgcccct ccctgtttga cttcacacac actcataact   2040

ttccaaatga aaccccacag tatagcgcat attttcgata tttttgtgaa ttccaaaagg   2100

aaatcacagg gctgttcgaa atattggggg aacactgtgt ttctgcatca tctgcatttg   2160

ctccccaagc aatgtagagg tgtttaaagg gccctctgct ggctgagtgg caatactaca   2220

acaaacttca aggcaagttt ggctgaaaac agttgacaac aaagggcccc catacactta   2280

tccctcaaat tttaagtgat atgaaatact tgtcatgtct ttggccaaat cagaagatat   2340

tcatcctgct tcaagtcagc ttcagaaatg ttttaaaagg gactttagct ctggaactca   2400

aaatcaattt attaagagcc atattcttta aaaaaaaaaa gctggataat attctctgta   2460

atatttcagt cctttacaag ccaaatacat gtgtcaatgt ttctagtatt tcaaagaagc   2520

aattatgtaa agttgttcaa tgtgacataa tagtattata attggttaag tagcttaatg   2580

attaggcaaa ctagatgaaa agattagggg cttccacact gcatagatta cacgcacata   2640

gccacgcata cacacacaga cacacagatg tggggtacac tgaacttcaa agcccaaatg   2700

aatagaaaca cattttctgg ctagcagaaa aaaacaaaac aaaactgttg tttctctttc   2760

ttgctttgag agtgtacagt aaaagggatt ttttcgaatt atttttatat tattttagct   2820

ttaattgtgc tgtcgttcat gaaacagagc tgctctgctt ttctgtcaga gatggcaagg   2880

gctttttcag catctcgttt atgtgtggaa tttaaaaaga ataaagtttt attccattct   2940

gtgtgaatgg tttgagcagt gaacaaagaa tccatgcaaa ccaagtcatg actggaagaa   3000

atggggagtg ggggacagtg caggggagga aagctgttac atctatgtta aatgattgtg   3060

agcagtctat aatgtcttga tgttggttca taggtgagac acaactgatg gaggaatgta   3120

ttataaatta tgcaaaatct gacatgagct gaaaagacag gtccttttat aagagctaat   3180

agatgcttag gatgcaaatg ttattttgag cttcgcaaat acatgatacc gtgcaataag   3240

ccttttttcc ttataacaga aaatgagaat aattaaaatg aggagaaggc cacataacag   3300

ttgacttgaa tttaattgaa ggacccattg gaggctcatc tggttgattt aattatttaa   3360

ttgagtgatt tattgcagat ctcttaatgc aggttagaaa cggaagtgag cataaacctt   3420

aaaaagactc taaatgatgc ttccaaagca ctttcatttt ggtattaggt tcatgtttgt   3480

ttgtctttac ttgtaaaata atttggaatt tttgtttaca gggtgaatgt cttaatagtt   3540

ttaaaattag ctaaatatat ctaaaggcat ttccaatgtt tatcatggga ggaaaaaagc   3600

cacatttttt ttaaaacaaa acaaaacaaa acaaaatttt ggtaatatag gttcaataca   3660

ctgtttttaa catctcagct tagccgcttt aatcatatca agatatgagg ctggatcact   3720

ggcccatgac aaatctgaaa cctaccagag aattgactgc tgcatagata atcctgctgc   3780

cagttaacat tccagaaaaa cttgggcagg caagttttta tagctgcccc actatgctgc   3840

aatagagtat ctttctattg aagattttcc actgcatccc gatcctacta tggtgaaagc   3900

attgttcttg ggctaaaaaa aaatccttta tttcatacac acatgatttc atacactagg   3960

tctgagcatc aagccaagtc catgagtttg caatgaagtt ctag                    4004


<210>  2545
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  2545

Met Asn Met Ser Val Leu Thr Leu Gln Glu Tyr Glu Phe Glu Lys Gln 
1               5                   10                  15


Phe Asn Glu Asn Glu Ala Ile Gln Trp Met Gln Glu Asn Trp Lys Lys 
            20                  25                  30


Ser Phe Leu Phe Ser Ala Leu Tyr Ala Ala Phe Ile Phe Gly Gly Arg 
        35                  40                  45


His Leu Met Asn Lys Arg Ala Lys Phe Glu Leu Arg Lys Pro Leu Val 
    50                  55                  60


Leu Trp Ser Leu Thr Leu Ala Val Phe Ser Ile Phe Gly Ala Leu Arg 
65                  70                  75                  80


Thr Gly Ala Tyr Met Val Tyr Ile Leu Met Thr Lys Gly Leu Lys Gln 
                85                  90                  95


Ser Val Cys Asp Gln Gly Phe Tyr Asn Gly Pro Val Ser Lys Phe Trp 
            100                 105                 110


Ala Tyr Ala Phe Val Leu Ser Lys Ala Pro Glu Leu Gly Asp Thr Ile 
        115                 120                 125


Phe Ile Ile Leu Arg Lys Gln Lys Leu Ile Phe Leu His Trp Tyr His 
    130                 135                 140


His Ile Thr Val Leu Leu Tyr Ser Trp Tyr Ser Tyr Lys Asp Met Val 
145                 150                 155                 160


Ala Gly Gly Gly Trp Phe Met Thr Met Asn Tyr Gly Val His Ala Val 
                165                 170                 175


Met Tyr Ser Tyr Tyr Ala Leu Arg Ala Ala Gly Phe Arg Val Ser Arg 
            180                 185                 190


Lys Phe Ala Met Phe Ile Thr Leu Ser Gln Ile Thr Gln Met Leu Met 
        195                 200                 205


Gly Cys Val Val Asn Tyr Leu Val Phe Cys Trp Met Gln His Asp Gln 
    210                 215                 220


Cys His Ser His Phe Gln Asn Ile Phe Trp Ser Ser Leu Met Tyr Leu 
225                 230                 235                 240


Ser Tyr Leu Val Leu Phe Cys His Phe Phe Phe Glu Ala Tyr Ile Gly 
                245                 250                 255


Lys Met Arg Lys Thr Thr Lys Ala Glu 
            260                 265


<210>  2546
<211>  4357
<212>  DNA
<213>  Homo sapiens

<400>  2546
gcaagctgaa acttcattca aagcaaggcg gcccacgagg ttgggcttag gggatctgga     60

tgacctccag gccacttcct ttctctctgc gcccttcccc cactcttcca accaccttcg    120

ctgtaaacaa aactgtcccc cccgggcgga gagaggtcgc gctctttcgc acactccctc    180

gccaagggtt aatttctcaa atcgcacgag ggggaggaga tttccctgta gacgagtaaa    240

aagggtgatg gacaaacgtg cgggcactaa gaccgcaagg cattcatttc ctcctacggt    300

ggatgcggac gccgggagga ggagagcccc agagagagga gctgggagcg gaggcgcagg    360

caatgctcag ccctggatgt agctgagagg ctgggagaag agacgaccgc tggagaccga    420

gcggcgtggg gaagacctag gggggtgggt gggggaagca gacaggagaa cactcgaaat    480

caagcgcttt acagattatt ttattttgta tagagaacac gtagcgactc cgaagatcag    540

ccccaatgaa catgtcagtg ttgactttac aagaatatga attcgaaaag cagttcaacg    600

agaatgaagc catccaatgg atgcaggaaa actggaagaa atctttcctg ttttctgctc    660

tgtatgctgc ctttatattc ggtggtcggc acctaatgaa taaacgagca aagtttgaac    720

tgaggaagcc attagtgctc tggtctctga cccttgcagt cttcagtata ttcggtgctc    780

ttcgaactgg tgcttatatg gtgtacattt tgatgaccaa aggcctgaag cagtcagttt    840

gtgaccaggg tttttacaat ggacctgtca gcaaattctg ggcttatgca tttgtgctaa    900

gcaaagcacc cgaactagga gatacaatat tcattattct gaggaagcag aagctgatct    960

tcctgcactg gtatcaccac atcactgtgc tcctgtactc ttggtactcc tacaaagaca   1020

tggttgccgg gggaggttgg ttcatgacta tgaactatgg cgtgcacgcc gtgatgtact   1080

cttactatgc cttgcgggcg gcaggtttcc gagtctcccg gaagtttgcc atgttcatca   1140

ccttgtccca gatcactcag atgctgatgg gctgtgtggt taactacctg gtcttctgct   1200

ggatgcagca tgaccagtgt cactctcact ttcagaacat cttctggtcc tcactcatgt   1260

acctcagcta ccttgtgctc ttctgccatt tcttctttga ggcctacatc ggcaaaatga   1320

ggaaaacaac gaaagctgaa tagtgttgga actgaggagg aagccatagc tcagggtcat   1380

caagaaaaat aatagacaaa agaaaatggc acaaggaatc acacgtggtg cagctaaaac   1440

aaaacaaaac atgagcaaac acaaaaccca aggcagctta gggataatta ggttgattta   1500

acccagtaag tttatgatcc ttttagggtg aggactcact gagtgcacct ccatctccaa   1560

gcactgctgc tggaagaccc cattccctct ttatctatca actctaggac aagggagaac   1620

aaaagcaagc cagaagcaga ggagactaat caaaggcaaa caaaggctat taacacatag   1680

gaaaaaatgt atttactaag tgtcacattt ctctaagatg aaagattttt actctagaaa   1740

ctgtgcgagc acaacacaca caatcctttc taactttatg gacactaaac tggagccaat   1800

agaaaagaca aaaatgaaag agacacaggg tgtatatcta gaacgataat gcttttgcag   1860

aaactaaagc ctttttaaga aatgccagct gctgtagacc ccatgagaaa agatgtctta   1920

atcatcctta tgaaaacaga tgtaaacaac tatatttcaa ctaacttcat cttcactgca   1980

tagcctcagg ctagtgagtt tgccaaaacc aaagggggtg aatacttccc caagattctt   2040

cctgggagga tggaaacagt gcagcccagg tcccatgggg gcagctccat cccagagcat   2100

ttctgatagt tgaactgtaa tttctactct taagtgagat atgaagcatt atccttttgt   2160

tcagttgccc cgggcttttg aacagaagag taaatacaga attgaaaaag ataaacactc   2220

aaccaaacaa tgtgaaaacg ggttctgtag tatttgtaaa aaggcccggc ccaggaccac   2280

tgtgagctgg aaaagggaga aaggcagtgg gaaaagaggt gagccgaaga tcaattcgac   2340

agacagatgg tgtgtatgcc cctccctgtt tgacttcaca cacactcata actttccaaa   2400

tgaaacccca cagtatagcg catattttcg atatttttgt gaattccaaa aggaaatcac   2460

agggctgttc gaaatattgg gggaacactg tgtttctgca tcatctgcat ttgctcccca   2520

agcaatgtag aggtgtttaa agggccctct gctggctgag tggcaatact acaacaaact   2580

tcaaggcaag tttggctgaa aacagttgac aacaaagggc ccccatacac ttatccctca   2640

aattttaagt gatatgaaat acttgtcatg tctttggcca aatcagaaga tattcatcct   2700

gcttcaagtc agcttcagaa atgttttaaa agggacttta gctctggaac tcaaaatcaa   2760

tttattaaga gccatattct ttaaaaaaaa aaagctggat aatattctct gtaatatttc   2820

agtcctttac aagccaaata catgtgtcaa tgtttctagt atttcaaaga agcaattatg   2880

taaagttgtt caatgtgaca taatagtatt ataattggtt aagtagctta atgattaggc   2940

aaactagatg aaaagattag gggcttccac actgcataga ttacacgcac atagccacgc   3000

atacacacac agacacacag atgtggggta cactgaactt caaagcccaa atgaatagaa   3060

acacattttc tggctagcag aaaaaaacaa aacaaaactg ttgtttctct ttcttgcttt   3120

gagagtgtac agtaaaaggg attttttcga attattttta tattatttta gctttaattg   3180

tgctgtcgtt catgaaacag agctgctctg cttttctgtc agagatggca agggcttttt   3240

cagcatctcg tttatgtgtg gaatttaaaa agaataaagt tttattccat tctgtgtgaa   3300

tggtttgagc agtgaacaaa gaatccatgc aaaccaagtc atgactggaa gaaatgggga   3360

gtgggggaca gtgcagggga ggaaagctgt tacatctatg ttaaatgatt gtgagcagtc   3420

tataatgtct tgatgttggt tcataggtga gacacaactg atggaggaat gtattataaa   3480

ttatgcaaaa tctgacatga gctgaaaaga caggtccttt tataagagct aatagatgct   3540

taggatgcaa atgttatttt gagcttcgca aatacatgat accgtgcaat aagccttttt   3600

tccttataac agaaaatgag aataattaaa atgaggagaa ggccacataa cagttgactt   3660

gaatttaatt gaaggaccca ttggaggctc atctggttga tttaattatt taattgagtg   3720

atttattgca gatctcttaa tgcaggttag aaacggaagt gagcataaac cttaaaaaga   3780

ctctaaatga tgcttccaaa gcactttcat tttggtatta ggttcatgtt tgtttgtctt   3840

tacttgtaaa ataatttgga atttttgttt acagggtgaa tgtcttaata gttttaaaat   3900

tagctaaata tatctaaagg catttccaat gtttatcatg ggaggaaaaa agccacattt   3960

tttttaaaac aaaacaaaac aaaacaaaat tttggtaata taggttcaat acactgtttt   4020

taacatctca gcttagccgc tttaatcata tcaagatatg aggctggatc actggcccat   4080

gacaaatctg aaacctacca gagaattgac tgctgcatag ataatcctgc tgccagttaa   4140

cattccagaa aaacttgggc aggcaagttt ttatagctgc cccactatgc tgcaatagag   4200

tatctttcta ttgaagattt tccactgcat cccgatccta ctatggtgaa agcattgttc   4260

ttgggctaaa aaaaaatcct ttatttcata cacacatgat ttcatacact aggtctgagc   4320

atcaagccaa gtccatgagt ttgcaatgaa gttctag                            4357


<210>  2547
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  2547

Met Asn Met Ser Val Leu Thr Leu Gln Glu Tyr Glu Phe Glu Lys Gln 
1               5                   10                  15


Phe Asn Glu Asn Glu Ala Ile Gln Trp Met Gln Glu Asn Trp Lys Lys 
            20                  25                  30


Ser Phe Leu Phe Ser Ala Leu Tyr Ala Ala Phe Ile Phe Gly Gly Arg 
        35                  40                  45


His Leu Met Asn Lys Arg Ala Lys Phe Glu Leu Arg Lys Pro Leu Val 
    50                  55                  60


Leu Trp Ser Leu Thr Leu Ala Val Phe Ser Ile Phe Gly Ala Leu Arg 
65                  70                  75                  80


Thr Gly Ala Tyr Met Val Tyr Ile Leu Met Thr Lys Gly Leu Lys Gln 
                85                  90                  95


Ser Val Cys Asp Gln Gly Phe Tyr Asn Gly Pro Val Ser Lys Phe Trp 
            100                 105                 110


Ala Tyr Ala Phe Val Leu Ser Lys Ala Pro Glu Leu Gly Asp Thr Ile 
        115                 120                 125


Phe Ile Ile Leu Arg Lys Gln Lys Leu Ile Phe Leu His Trp Tyr His 
    130                 135                 140


His Ile Thr Val Leu Leu Tyr Ser Trp Tyr Ser Tyr Lys Asp Met Val 
145                 150                 155                 160


Ala Gly Gly Gly Trp Phe Met Thr Met Asn Tyr Gly Val His Ala Val 
                165                 170                 175


Met Tyr Ser Tyr Tyr Ala Leu Arg Ala Ala Gly Phe Arg Val Ser Arg 
            180                 185                 190


Lys Phe Ala Met Phe Ile Thr Leu Ser Gln Ile Thr Gln Met Leu Met 
        195                 200                 205


Gly Cys Val Val Asn Tyr Leu Val Phe Cys Trp Met Gln His Asp Gln 
    210                 215                 220


Cys His Ser His Phe Gln Asn Ile Phe Trp Ser Ser Leu Met Tyr Leu 
225                 230                 235                 240


Ser Tyr Leu Val Leu Phe Cys His Phe Phe Phe Glu Ala Tyr Ile Gly 
                245                 250                 255


Lys Met Arg Lys Thr Thr Lys Ala Glu 
            260                 265


<210>  2548
<211>  4014
<212>  DNA
<213>  Homo sapiens

<400>  2548
gtattccctt cactggtgat ctcaacgtag atttgcccgg agttctcttg caagagagct     60

ggcaggtttt actatttccc aatcgtttac tcgccaagct ctcgggtcca cgcgccgcgg    120

ggatgcgccc tgcaagctga aacttcattc aaagcaaggc ggcccacgag agaacacgta    180

gcgactccga agatcagccc caatgaacat gtcagtgttg actttacaag aatatgaatt    240

cgaaaagcag ttcaacgaga atgaagccat ccaatggatg caggaaaact ggaagaaatc    300

tttcctgttt tctgctctgt atgctgcctt tatattcggt ggtcggcacc taatgaataa    360

acgagcaaag tttgaactga ggaagccatt agtgctctgg tctctgaccc ttgcagtctt    420

cagtatattc ggtgctcttc gaactggtgc ttatatggtg tacattttga tgaccaaagg    480

cctgaagcag tcagtttgtg accagggttt ttacaatgga cctgtcagca aattctgggc    540

ttatgcattt gtgctaagca aagcacccga actaggagat acaatattca ttattctgag    600

gaagcagaag ctgatcttcc tgcactggta tcaccacatc actgtgctcc tgtactcttg    660

gtactcctac aaagacatgg ttgccggggg aggttggttc atgactatga actatggcgt    720

gcacgccgtg atgtactctt actatgcctt gcgggcggca ggtttccgag tctcccggaa    780

gtttgccatg ttcatcacct tgtcccagat cactcagatg ctgatgggct gtgtggttaa    840

ctacctggtc ttctgctgga tgcagcatga ccagtgtcac tctcactttc agaacatctt    900

ctggtcctca ctcatgtacc tcagctacct tgtgctcttc tgccatttct tctttgaggc    960

ctacatcggc aaaatgagga aaacaacgaa agctgaatag tgttggaact gaggaggaag   1020

ccatagctca gggtcatcaa gaaaaataat agacaaaaga aaatggcaca aggaatcaca   1080

cgtggtgcag ctaaaacaaa acaaaacatg agcaaacaca aaacccaagg cagcttaggg   1140

ataattaggt tgatttaacc cagtaagttt atgatccttt tagggtgagg actcactgag   1200

tgcacctcca tctccaagca ctgctgctgg aagaccccat tccctcttta tctatcaact   1260

ctaggacaag ggagaacaaa agcaagccag aagcagagga gactaatcaa aggcaaacaa   1320

aggctattaa cacataggaa aaaatgtatt tactaagtgt cacatttctc taagatgaaa   1380

gatttttact ctagaaactg tgcgagcaca acacacacaa tcctttctaa ctttatggac   1440

actaaactgg agccaataga aaagacaaaa atgaaagaga cacagggtgt atatctagaa   1500

cgataatgct tttgcagaaa ctaaagcctt tttaagaaat gccagctgct gtagacccca   1560

tgagaaaaga tgtcttaatc atccttatga aaacagatgt aaacaactat atttcaacta   1620

acttcatctt cactgcatag cctcaggcta gtgagtttgc caaaaccaaa gggggtgaat   1680

acttccccaa gattcttcct gggaggatgg aaacagtgca gcccaggtcc catgggggca   1740

gctccatccc agagcatttc tgatagttga actgtaattt ctactcttaa gtgagatatg   1800

aagcattatc cttttgttca gttgccccgg gcttttgaac agaagagtaa atacagaatt   1860

gaaaaagata aacactcaac caaacaatgt gaaaacgggt tctgtagtat ttgtaaaaag   1920

gcccggccca ggaccactgt gagctggaaa agggagaaag gcagtgggaa aagaggtgag   1980

ccgaagatca attcgacaga cagatggtgt gtatgcccct ccctgtttga cttcacacac   2040

actcataact ttccaaatga aaccccacag tatagcgcat attttcgata tttttgtgaa   2100

ttccaaaagg aaatcacagg gctgttcgaa atattggggg aacactgtgt ttctgcatca   2160

tctgcatttg ctccccaagc aatgtagagg tgtttaaagg gccctctgct ggctgagtgg   2220

caatactaca acaaacttca aggcaagttt ggctgaaaac agttgacaac aaagggcccc   2280

catacactta tccctcaaat tttaagtgat atgaaatact tgtcatgtct ttggccaaat   2340

cagaagatat tcatcctgct tcaagtcagc ttcagaaatg ttttaaaagg gactttagct   2400

ctggaactca aaatcaattt attaagagcc atattcttta aaaaaaaaaa gctggataat   2460

attctctgta atatttcagt cctttacaag ccaaatacat gtgtcaatgt ttctagtatt   2520

tcaaagaagc aattatgtaa agttgttcaa tgtgacataa tagtattata attggttaag   2580

tagcttaatg attaggcaaa ctagatgaaa agattagggg cttccacact gcatagatta   2640

cacgcacata gccacgcata cacacacaga cacacagatg tggggtacac tgaacttcaa   2700

agcccaaatg aatagaaaca cattttctgg ctagcagaaa aaaacaaaac aaaactgttg   2760

tttctctttc ttgctttgag agtgtacagt aaaagggatt ttttcgaatt atttttatat   2820

tattttagct ttaattgtgc tgtcgttcat gaaacagagc tgctctgctt ttctgtcaga   2880

gatggcaagg gctttttcag catctcgttt atgtgtggaa tttaaaaaga ataaagtttt   2940

attccattct gtgtgaatgg tttgagcagt gaacaaagaa tccatgcaaa ccaagtcatg   3000

actggaagaa atggggagtg ggggacagtg caggggagga aagctgttac atctatgtta   3060

aatgattgtg agcagtctat aatgtcttga tgttggttca taggtgagac acaactgatg   3120

gaggaatgta ttataaatta tgcaaaatct gacatgagct gaaaagacag gtccttttat   3180

aagagctaat agatgcttag gatgcaaatg ttattttgag cttcgcaaat acatgatacc   3240

gtgcaataag ccttttttcc ttataacaga aaatgagaat aattaaaatg aggagaaggc   3300

cacataacag ttgacttgaa tttaattgaa ggacccattg gaggctcatc tggttgattt   3360

aattatttaa ttgagtgatt tattgcagat ctcttaatgc aggttagaaa cggaagtgag   3420

cataaacctt aaaaagactc taaatgatgc ttccaaagca ctttcatttt ggtattaggt   3480

tcatgtttgt ttgtctttac ttgtaaaata atttggaatt tttgtttaca gggtgaatgt   3540

cttaatagtt ttaaaattag ctaaatatat ctaaaggcat ttccaatgtt tatcatggga   3600

ggaaaaaagc cacatttttt ttaaaacaaa acaaaacaaa acaaaatttt ggtaatatag   3660

gttcaataca ctgtttttaa catctcagct tagccgcttt aatcatatca agatatgagg   3720

ctggatcact ggcccatgac aaatctgaaa cctaccagag aattgactgc tgcatagata   3780

atcctgctgc cagttaacat tccagaaaaa cttgggcagg caagttttta tagctgcccc   3840

actatgctgc aatagagtat ctttctattg aagattttcc actgcatccc gatcctacta   3900

tggtgaaagc attgttcttg ggctaaaaaa aaatccttta tttcatacac acatgatttc   3960

atacactagg tctgagcatc aagccaagtc catgagtttg caatgaagtt ctag         4014


<210>  2549
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  2549

Met Asn Met Ser Val Leu Thr Leu Gln Glu Tyr Glu Phe Glu Lys Gln 
1               5                   10                  15


Phe Asn Glu Asn Glu Ala Ile Gln Trp Met Gln Glu Asn Trp Lys Lys 
            20                  25                  30


Ser Phe Leu Phe Ser Ala Leu Tyr Ala Ala Phe Ile Phe Gly Gly Arg 
        35                  40                  45


His Leu Met Asn Lys Arg Ala Lys Phe Glu Leu Arg Lys Pro Leu Val 
    50                  55                  60


Leu Trp Ser Leu Thr Leu Ala Val Phe Ser Ile Phe Gly Ala Leu Arg 
65                  70                  75                  80


Thr Gly Ala Tyr Met Val Tyr Ile Leu Met Thr Lys Gly Leu Lys Gln 
                85                  90                  95


Ser Val Cys Asp Gln Gly Phe Tyr Asn Gly Pro Val Ser Lys Phe Trp 
            100                 105                 110


Ala Tyr Ala Phe Val Leu Ser Lys Ala Pro Glu Leu Gly Asp Thr Ile 
        115                 120                 125


Phe Ile Ile Leu Arg Lys Gln Lys Leu Ile Phe Leu His Trp Tyr His 
    130                 135                 140


His Ile Thr Val Leu Leu Tyr Ser Trp Tyr Ser Tyr Lys Asp Met Val 
145                 150                 155                 160


Ala Gly Gly Gly Trp Phe Met Thr Met Asn Tyr Gly Val His Ala Val 
                165                 170                 175


Met Tyr Ser Tyr Tyr Ala Leu Arg Ala Ala Gly Phe Arg Val Ser Arg 
            180                 185                 190


Lys Phe Ala Met Phe Ile Thr Leu Ser Gln Ile Thr Gln Met Leu Met 
        195                 200                 205


Gly Cys Val Val Asn Tyr Leu Val Phe Cys Trp Met Gln His Asp Gln 
    210                 215                 220


Cys His Ser His Phe Gln Asn Ile Phe Trp Ser Ser Leu Met Tyr Leu 
225                 230                 235                 240


Ser Tyr Leu Val Leu Phe Cys His Phe Phe Phe Glu Ala Tyr Ile Gly 
                245                 250                 255


Lys Met Arg Lys Thr Thr Lys Ala Glu 
            260                 265


<210>  2550
<211>  3953
<212>  DNA
<213>  Homo sapiens

<400>  2550
ctctcgccta tccactatcc tcacactcag catcccctgt ctgtacgaga ttaaggagct     60

ctgccgtccg cagggcctgg agaacacgta gcgactccga agatcagccc caatgaacat    120

gtcagtgttg actttacaag aatatgaatt cgaaaagcag ttcaacgaga atgaagccat    180

ccaatggatg caggaaaact ggaagaaatc tttcctgttt tctgctctgt atgctgcctt    240

tatattcggt ggtcggcacc taatgaataa acgagcaaag tttgaactga ggaagccatt    300

agtgctctgg tctctgaccc ttgcagtctt caggtgctat aacaacttga aacagctgac    360

attatattcg gtgctcttcg aactggtgct tatatggtgt acattttgat gaccaaaggc    420

ctgaagcagt cagtttgtga ccagggtttt tacaatggac ctgtcagcaa attctgggct    480

tatgcatttg tgctaagcaa agcacccgaa ctaggagata caatattcat tattctgagg    540

aagcagaagc tgatcttcct gcactggtat caccacatca ctgtgctcct gtactcttgg    600

tactcctaca aagacatggt tgccggggga ggttggttca tgactatgaa ctatggcgtg    660

cacgccgtga tgtactctta ctatgccttg cgggcggcag gtttccgagt ctcccggaag    720

tttgccatgt tcatcacctt gtcccagatc actcagatgc tgatgggctg tgtggttaac    780

tacctggtct tctgctggat gcagcatgac cagtgtcact ctcactttca gaacatcttc    840

tggtcctcac tcatgtacct cagctacctt gtgctcttct gccatttctt ctttgaggcc    900

tacatcggca aaatgaggaa aacaacgaaa gctgaatagt gttggaactg aggaggaagc    960

catagctcag ggtcatcaag aaaaataata gacaaaagaa aatggcacaa ggaatcacac   1020

gtggtgcagc taaaacaaaa caaaacatga gcaaacacaa aacccaaggc agcttaggga   1080

taattaggtt gatttaaccc agtaagttta tgatcctttt agggtgagga ctcactgagt   1140

gcacctccat ctccaagcac tgctgctgga agaccccatt ccctctttat ctatcaactc   1200

taggacaagg gagaacaaaa gcaagccaga agcagaggag actaatcaaa ggcaaacaaa   1260

ggctattaac acataggaaa aaatgtattt actaagtgtc acatttctct aagatgaaag   1320

atttttactc tagaaactgt gcgagcacaa cacacacaat cctttctaac tttatggaca   1380

ctaaactgga gccaatagaa aagacaaaaa tgaaagagac acagggtgta tatctagaac   1440

gataatgctt ttgcagaaac taaagccttt ttaagaaatg ccagctgctg tagaccccat   1500

gagaaaagat gtcttaatca tccttatgaa aacagatgta aacaactata tttcaactaa   1560

cttcatcttc actgcatagc ctcaggctag tgagtttgcc aaaaccaaag ggggtgaata   1620

cttccccaag attcttcctg ggaggatgga aacagtgcag cccaggtccc atgggggcag   1680

ctccatccca gagcatttct gatagttgaa ctgtaatttc tactcttaag tgagatatga   1740

agcattatcc ttttgttcag ttgccccggg cttttgaaca gaagagtaaa tacagaattg   1800

aaaaagataa acactcaacc aaacaatgtg aaaacgggtt ctgtagtatt tgtaaaaagg   1860

cccggcccag gaccactgtg agctggaaaa gggagaaagg cagtgggaaa agaggtgagc   1920

cgaagatcaa ttcgacagac agatggtgtg tatgcccctc cctgtttgac ttcacacaca   1980

ctcataactt tccaaatgaa accccacagt atagcgcata ttttcgatat ttttgtgaat   2040

tccaaaagga aatcacaggg ctgttcgaaa tattggggga acactgtgtt tctgcatcat   2100

ctgcatttgc tccccaagca atgtagaggt gtttaaaggg ccctctgctg gctgagtggc   2160

aatactacaa caaacttcaa ggcaagtttg gctgaaaaca gttgacaaca aagggccccc   2220

atacacttat ccctcaaatt ttaagtgata tgaaatactt gtcatgtctt tggccaaatc   2280

agaagatatt catcctgctt caagtcagct tcagaaatgt tttaaaaggg actttagctc   2340

tggaactcaa aatcaattta ttaagagcca tattctttaa aaaaaaaaag ctggataata   2400

ttctctgtaa tatttcagtc ctttacaagc caaatacatg tgtcaatgtt tctagtattt   2460

caaagaagca attatgtaaa gttgttcaat gtgacataat agtattataa ttggttaagt   2520

agcttaatga ttaggcaaac tagatgaaaa gattaggggc ttccacactg catagattac   2580

acgcacatag ccacgcatac acacacagac acacagatgt ggggtacact gaacttcaaa   2640

gcccaaatga atagaaacac attttctggc tagcagaaaa aaacaaaaca aaactgttgt   2700

ttctctttct tgctttgaga gtgtacagta aaagggattt tttcgaatta tttttatatt   2760

attttagctt taattgtgct gtcgttcatg aaacagagct gctctgcttt tctgtcagag   2820

atggcaaggg ctttttcagc atctcgttta tgtgtggaat ttaaaaagaa taaagtttta   2880

ttccattctg tgtgaatggt ttgagcagtg aacaaagaat ccatgcaaac caagtcatga   2940

ctggaagaaa tggggagtgg gggacagtgc aggggaggaa agctgttaca tctatgttaa   3000

atgattgtga gcagtctata atgtcttgat gttggttcat aggtgagaca caactgatgg   3060

aggaatgtat tataaattat gcaaaatctg acatgagctg aaaagacagg tccttttata   3120

agagctaata gatgcttagg atgcaaatgt tattttgagc ttcgcaaata catgataccg   3180

tgcaataagc cttttttcct tataacagaa aatgagaata attaaaatga ggagaaggcc   3240

acataacagt tgacttgaat ttaattgaag gacccattgg aggctcatct ggttgattta   3300

attatttaat tgagtgattt attgcagatc tcttaatgca ggttagaaac ggaagtgagc   3360

ataaacctta aaaagactct aaatgatgct tccaaagcac tttcattttg gtattaggtt   3420

catgtttgtt tgtctttact tgtaaaataa tttggaattt ttgtttacag ggtgaatgtc   3480

ttaatagttt taaaattagc taaatatatc taaaggcatt tccaatgttt atcatgggag   3540

gaaaaaagcc acattttttt taaaacaaaa caaaacaaaa caaaattttg gtaatatagg   3600

ttcaatacac tgtttttaac atctcagctt agccgcttta atcatatcaa gatatgaggc   3660

tggatcactg gcccatgaca aatctgaaac ctaccagaga attgactgct gcatagataa   3720

tcctgctgcc agttaacatt ccagaaaaac ttgggcaggc aagtttttat agctgcccca   3780

ctatgctgca atagagtatc tttctattga agattttcca ctgcatcccg atcctactat   3840

ggtgaaagca ttgttcttgg gctaaaaaaa aatcctttat ttcatacaca catgatttca   3900

tacactaggt ctgagcatca agccaagtcc atgagtttgc aatgaagttc tag          3953


<210>  2551
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  2551

Met Val Tyr Ile Leu Met Thr Lys Gly Leu Lys Gln Ser Val Cys Asp 
1               5                   10                  15


Gln Gly Phe Tyr Asn Gly Pro Val Ser Lys Phe Trp Ala Tyr Ala Phe 
            20                  25                  30


Val Leu Ser Lys Ala Pro Glu Leu Gly Asp Thr Ile Phe Ile Ile Leu 
        35                  40                  45


Arg Lys Gln Lys Leu Ile Phe Leu His Trp Tyr His His Ile Thr Val 
    50                  55                  60


Leu Leu Tyr Ser Trp Tyr Ser Tyr Lys Asp Met Val Ala Gly Gly Gly 
65                  70                  75                  80


Trp Phe Met Thr Met Asn Tyr Gly Val His Ala Val Met Tyr Ser Tyr 
                85                  90                  95


Tyr Ala Leu Arg Ala Ala Gly Phe Arg Val Ser Arg Lys Phe Ala Met 
            100                 105                 110


Phe Ile Thr Leu Ser Gln Ile Thr Gln Met Leu Met Gly Cys Val Val 
        115                 120                 125


Asn Tyr Leu Val Phe Cys Trp Met Gln His Asp Gln Cys His Ser His 
    130                 135                 140


Phe Gln Asn Ile Phe Trp Ser Ser Leu Met Tyr Leu Ser Tyr Leu Val 
145                 150                 155                 160


Leu Phe Cys His Phe Phe Phe Glu Ala Tyr Ile Gly Lys Met Arg Lys 
                165                 170                 175


Thr Thr Lys Ala Glu 
            180


<210>  2552
<211>  3944
<212>  DNA
<213>  Homo sapiens

<400>  2552
ccacttccgg ctactagcct ctctcgccta tccactatcc tcacactcag catcccctgt     60

ctgtacgaga ttaaggagct ctgccgtccg cagggcctgg agaacacgta gcgactccga    120

agatcagccc caatgaacat gtcagtgttg actttacaag aatatgaatt cgaaaagcag    180

ttcaacgaga atgaagccat ccaatggatg caggaaaact ggaagaaatc tttcctgttt    240

tctgctctgt atgctgcctt tatattcggt ggtcggcacc taatgaataa acgagcaaag    300

tttgaactga ggaagccatt agtgctctgg tctctgaccc ttgcagtctt cagtatattc    360

ggtgctcttc gaactggtgc ttatatggtg tacattttga tgaccaaagg cctgaagcag    420

tcagtttgtg accagggttt ttacaatgga cctgtcagca aattctgggc ttatgcattt    480

gtgctaagca aagcacccga actaggagat acaatattca ttattctgag gaagcagaag    540

ctgatcttcc tgcactggta tcaccacatc actgtgctcc tgtactcttg gtactcctac    600

aaagacatgg ttgccggggg aggttggttc atgactatga actatggcgt gcacgccgtg    660

atgtactctt actatgcctt gcgggcggca ggtttccgag tctcccggaa gtttgccatg    720

ttcatcacct tgtcccagat cactcagatg ctgatgggct gtgtggttaa ctacctggtc    780

ttctgctgga tgcagcatga ccagtgtcac tctcactttc agaacatctt ctggtcctca    840

ctcatgtacc tcagctacct tgtgctcttc tgccatttct tctttgaggc ctacatcggc    900

aaaatgagga aaacaacgaa agctgaatag tgttggaact gaggaggaag ccatagctca    960

gggtcatcaa gaaaaataat agacaaaaga aaatggcaca aggaatcaca cgtggtgcag   1020

ctaaaacaaa acaaaacatg agcaaacaca aaacccaagg cagcttaggg ataattaggt   1080

tgatttaacc cagtaagttt atgatccttt tagggtgagg actcactgag tgcacctcca   1140

tctccaagca ctgctgctgg aagaccccat tccctcttta tctatcaact ctaggacaag   1200

ggagaacaaa agcaagccag aagcagagga gactaatcaa aggcaaacaa aggctattaa   1260

cacataggaa aaaatgtatt tactaagtgt cacatttctc taagatgaaa gatttttact   1320

ctagaaactg tgcgagcaca acacacacaa tcctttctaa ctttatggac actaaactgg   1380

agccaataga aaagacaaaa atgaaagaga cacagggtgt atatctagaa cgataatgct   1440

tttgcagaaa ctaaagcctt tttaagaaat gccagctgct gtagacccca tgagaaaaga   1500

tgtcttaatc atccttatga aaacagatgt aaacaactat atttcaacta acttcatctt   1560

cactgcatag cctcaggcta gtgagtttgc caaaaccaaa gggggtgaat acttccccaa   1620

gattcttcct gggaggatgg aaacagtgca gcccaggtcc catgggggca gctccatccc   1680

agagcatttc tgatagttga actgtaattt ctactcttaa gtgagatatg aagcattatc   1740

cttttgttca gttgccccgg gcttttgaac agaagagtaa atacagaatt gaaaaagata   1800

aacactcaac caaacaatgt gaaaacgggt tctgtagtat ttgtaaaaag gcccggccca   1860

ggaccactgt gagctggaaa agggagaaag gcagtgggaa aagaggtgag ccgaagatca   1920

attcgacaga cagatggtgt gtatgcccct ccctgtttga cttcacacac actcataact   1980

ttccaaatga aaccccacag tatagcgcat attttcgata tttttgtgaa ttccaaaagg   2040

aaatcacagg gctgttcgaa atattggggg aacactgtgt ttctgcatca tctgcatttg   2100

ctccccaagc aatgtagagg tgtttaaagg gccctctgct ggctgagtgg caatactaca   2160

acaaacttca aggcaagttt ggctgaaaac agttgacaac aaagggcccc catacactta   2220

tccctcaaat tttaagtgat atgaaatact tgtcatgtct ttggccaaat cagaagatat   2280

tcatcctgct tcaagtcagc ttcagaaatg ttttaaaagg gactttagct ctggaactca   2340

aaatcaattt attaagagcc atattcttta aaaaaaaaaa gctggataat attctctgta   2400

atatttcagt cctttacaag ccaaatacat gtgtcaatgt ttctagtatt tcaaagaagc   2460

aattatgtaa agttgttcaa tgtgacataa tagtattata attggttaag tagcttaatg   2520

attaggcaaa ctagatgaaa agattagggg cttccacact gcatagatta cacgcacata   2580

gccacgcata cacacacaga cacacagatg tggggtacac tgaacttcaa agcccaaatg   2640

aatagaaaca cattttctgg ctagcagaaa aaaacaaaac aaaactgttg tttctctttc   2700

ttgctttgag agtgtacagt aaaagggatt ttttcgaatt atttttatat tattttagct   2760

ttaattgtgc tgtcgttcat gaaacagagc tgctctgctt ttctgtcaga gatggcaagg   2820

gctttttcag catctcgttt atgtgtggaa tttaaaaaga ataaagtttt attccattct   2880

gtgtgaatgg tttgagcagt gaacaaagaa tccatgcaaa ccaagtcatg actggaagaa   2940

atggggagtg ggggacagtg caggggagga aagctgttac atctatgtta aatgattgtg   3000

agcagtctat aatgtcttga tgttggttca taggtgagac acaactgatg gaggaatgta   3060

ttataaatta tgcaaaatct gacatgagct gaaaagacag gtccttttat aagagctaat   3120

agatgcttag gatgcaaatg ttattttgag cttcgcaaat acatgatacc gtgcaataag   3180

ccttttttcc ttataacaga aaatgagaat aattaaaatg aggagaaggc cacataacag   3240

ttgacttgaa tttaattgaa ggacccattg gaggctcatc tggttgattt aattatttaa   3300

ttgagtgatt tattgcagat ctcttaatgc aggttagaaa cggaagtgag cataaacctt   3360

aaaaagactc taaatgatgc ttccaaagca ctttcatttt ggtattaggt tcatgtttgt   3420

ttgtctttac ttgtaaaata atttggaatt tttgtttaca gggtgaatgt cttaatagtt   3480

ttaaaattag ctaaatatat ctaaaggcat ttccaatgtt tatcatggga ggaaaaaagc   3540

cacatttttt ttaaaacaaa acaaaacaaa acaaaatttt ggtaatatag gttcaataca   3600

ctgtttttaa catctcagct tagccgcttt aatcatatca agatatgagg ctggatcact   3660

ggcccatgac aaatctgaaa cctaccagag aattgactgc tgcatagata atcctgctgc   3720

cagttaacat tccagaaaaa cttgggcagg caagttttta tagctgcccc actatgctgc   3780

aatagagtat ctttctattg aagattttcc actgcatccc gatcctacta tggtgaaagc   3840

attgttcttg ggctaaaaaa aaatccttta tttcatacac acatgatttc atacactagg   3900

tctgagcatc aagccaagtc catgagtttg caatgaagtt ctag                    3944


<210>  2553
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  2553

Met Asn Met Ser Val Leu Thr Leu Gln Glu Tyr Glu Phe Glu Lys Gln 
1               5                   10                  15


Phe Asn Glu Asn Glu Ala Ile Gln Trp Met Gln Glu Asn Trp Lys Lys 
            20                  25                  30


Ser Phe Leu Phe Ser Ala Leu Tyr Ala Ala Phe Ile Phe Gly Gly Arg 
        35                  40                  45


His Leu Met Asn Lys Arg Ala Lys Phe Glu Leu Arg Lys Pro Leu Val 
    50                  55                  60


Leu Trp Ser Leu Thr Leu Ala Val Phe Ser Ile Phe Gly Ala Leu Arg 
65                  70                  75                  80


Thr Gly Ala Tyr Met Val Tyr Ile Leu Met Thr Lys Gly Leu Lys Gln 
                85                  90                  95


Ser Val Cys Asp Gln Gly Phe Tyr Asn Gly Pro Val Ser Lys Phe Trp 
            100                 105                 110


Ala Tyr Ala Phe Val Leu Ser Lys Ala Pro Glu Leu Gly Asp Thr Ile 
        115                 120                 125


Phe Ile Ile Leu Arg Lys Gln Lys Leu Ile Phe Leu His Trp Tyr His 
    130                 135                 140


His Ile Thr Val Leu Leu Tyr Ser Trp Tyr Ser Tyr Lys Asp Met Val 
145                 150                 155                 160


Ala Gly Gly Gly Trp Phe Met Thr Met Asn Tyr Gly Val His Ala Val 
                165                 170                 175


Met Tyr Ser Tyr Tyr Ala Leu Arg Ala Ala Gly Phe Arg Val Ser Arg 
            180                 185                 190


Lys Phe Ala Met Phe Ile Thr Leu Ser Gln Ile Thr Gln Met Leu Met 
        195                 200                 205


Gly Cys Val Val Asn Tyr Leu Val Phe Cys Trp Met Gln His Asp Gln 
    210                 215                 220


Cys His Ser His Phe Gln Asn Ile Phe Trp Ser Ser Leu Met Tyr Leu 
225                 230                 235                 240


Ser Tyr Leu Val Leu Phe Cys His Phe Phe Phe Glu Ala Tyr Ile Gly 
                245                 250                 255


Lys Met Arg Lys Thr Thr Lys Ala Glu 
            260                 265


<210>  2554
<211>  2896
<212>  DNA
<213>  Homo sapiens

<400>  2554
attcatttcc tcctacggtg gatgcggacg ccgggaggag gagagcccca gagagaggag     60

ctgggagcgg aggcgcaggc aatgctcagc cctggatgta gctgagaggc tgggagaaga    120

gacgaccgct ggagaccgag cggcgtgggg aagacctagg ggggtgggtg ggggaagcag    180

acaggagaac attcaacgag aatgaagcca tccaatggat gcaggaaaac tggaagaaat    240

ctttcctgtt ttctgctctg tatgctgcct ttatattcgg tggtcggcac ctaatgaata    300

aacgagcaaa gtttgaactg aggaagccat tagtgctctg gtctctgacc cttgcagtct    360

tcagtatatt cggtgctctt cgaactggtg cttatatggt gtacattttg atgaccaaag    420

gcctgaagca gtcagtttgt gaccagggtt tttacaatgg acctgtcagc aaattctggg    480

cttatgcatt tgtgctaagc aaagcacccg aactaggaga tacaatattc attattctga    540

ggaagcagaa gctgatcttc ctgcactggt atcaccacat cactgtgctc ctgtactctt    600

ggtactccta caaagacatg gttgccgggg gaggttggtt catgactatg aactatggcg    660

tgcacgccgt gatgtactct tactatgcct tgcgggcggc aggtttccga gtctcccgga    720

agtttgccat gttcatcacc ttgtcccaga tcactcagat gctgatgggc tgtgtggtta    780

actacctggt cttctgctgg atgcagcatg accagtgtca ctctcacttt cagaacatct    840

tctggtcctc actcatgtac ctcagctacc ttgtgctctt ctgccatttc ttctttgagg    900

cctacatcgg caaaatgagg aaaacaacga aagctgaata gtgttggaac tgaggaggaa    960

gccatagctc agggtcatca agaaaaataa tagacaaaag aaaatggcac aaggaatcac   1020

acgtggtgca gctaaaacaa aacaaaacat gagcaaacac aaaacccaag gcagcttagg   1080

gataattagg ttgatttaac ccagtaagtt tatgatcctt ttagggtgag gactcactga   1140

gtgcacctcc atctccaagc actgctgctg gaagacccca ttccctcttt atctatcaac   1200

tctaggacaa gggagaacaa aagcaagcca gaagcagagg agactaatca aaggcaaaca   1260

aaggctatta acacatagga aaaaatgtat ttactaagtg tcacatttct ctaagatgaa   1320

agatttttac tctagaaact gtgcgagcac aacacacaca atcctttcta actttatgga   1380

cactaaactg gagccaatag aaaagacaaa aatgaaagag acacagggtg tatatctaga   1440

acgataatgc ttttgcagaa actaaagcct ttttaagaaa tgccagctgc tgtagacccc   1500

atgagaaaag atgtcttaat catccttatg aaaacagatg taaacaacta tatttcaact   1560

aacttcatct tcactgcata gcctcaggct agtgagtttg ccaaaaccaa agggggtgaa   1620

tacttcccca agattcttcc tgggaggatg gaaacagtgc agcccaggtc ccatgggggc   1680

agctccatcc cagagcattt ctgatagttg aactgtaatt tctactctta agtgagatat   1740

gaagcattat ccttttgttc agttgccccg ggcttttgaa cagaagagta aatacagaat   1800

tgaaaaagat aaacactcaa ccaaacaatg tgaaaacggg ttctgtagta tttgtaaaaa   1860

ggcccggccc aggaccactg tgagctggaa aagggagaaa ggcagtggga aaagaggtga   1920

gccgaagatc aattcgacag acagatggtg tgtatgcccc tccctgtttg acttcacaca   1980

cactcataac tttccaaatg aaaccccaca gtatagcgca tattttcgat atttttgtga   2040

attccaaaag gaaatcacag ggctgttcga aatattgggg gaacactgtg tttctgcatc   2100

atctgcattt gctccccaag caatgtagag gtgtttaaag ggccctctgc tggctgagtg   2160

gcaatactac aacaaacttc aaggcaagtt tggctgaaaa cagttgacaa caaagggccc   2220

ccatacactt atccctcaaa ttttaagtga tatgaaatac ttgtcatgtc tttggccaaa   2280

tcagaagata ttcatcctgc ttcaagtcag cttcagaaat gttttaaaag ggactttagc   2340

tctggaactc aaaatcaatt tattaagagc catattcttt aaaaaaaaaa agctggataa   2400

tattctctgt aatatttcag tcctttacaa gccaaataca tgtgtcaatg tttctagtat   2460

ttcaaagaag caattatgta aagttgttca atgtgacata atagtattat aattggttaa   2520

gtagcttaat gattaggcaa actagatgaa aagattaggg gcttccacac tgcatagatt   2580

acacgcacat agccacgcat acacacacag acacacagat gtggggtaca ctgaacttca   2640

aagcccaaat gaatagaaac acattttctg gctagcagaa aaaaacaaaa caaaactgtt   2700

gtttctcttt cttgctttga gagtgtacag taaaagggat tttttcgaat tatttttata   2760

ttattttagc tttaattgtg ctgtcgttca tgaaacagag ctgctctgct tttctgtcag   2820

agatggcaag ggctttttca gcatctcgtt tatgtgtgga atttaaaaag aataaagttt   2880

tattccattc tgtgtg                                                   2896


<210>  2555
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  2555

Met Gln Glu Asn Trp Lys Lys Ser Phe Leu Phe Ser Ala Leu Tyr Ala 
1               5                   10                  15


Ala Phe Ile Phe Gly Gly Arg His Leu Met Asn Lys Arg Ala Lys Phe 
            20                  25                  30


Glu Leu Arg Lys Pro Leu Val Leu Trp Ser Leu Thr Leu Ala Val Phe 
        35                  40                  45


Ser Ile Phe Gly Ala Leu Arg Thr Gly Ala Tyr Met Val Tyr Ile Leu 
    50                  55                  60


Met Thr Lys Gly Leu Lys Gln Ser Val Cys Asp Gln Gly Phe Tyr Asn 
65                  70                  75                  80


Gly Pro Val Ser Lys Phe Trp Ala Tyr Ala Phe Val Leu Ser Lys Ala 
                85                  90                  95


Pro Glu Leu Gly Asp Thr Ile Phe Ile Ile Leu Arg Lys Gln Lys Leu 
            100                 105                 110


Ile Phe Leu His Trp Tyr His His Ile Thr Val Leu Leu Tyr Ser Trp 
        115                 120                 125


Tyr Ser Tyr Lys Asp Met Val Ala Gly Gly Gly Trp Phe Met Thr Met 
    130                 135                 140


Asn Tyr Gly Val His Ala Val Met Tyr Ser Tyr Tyr Ala Leu Arg Ala 
145                 150                 155                 160


Ala Gly Phe Arg Val Ser Arg Lys Phe Ala Met Phe Ile Thr Leu Ser 
                165                 170                 175


Gln Ile Thr Gln Met Leu Met Gly Cys Val Val Asn Tyr Leu Val Phe 
            180                 185                 190


Cys Trp Met Gln His Asp Gln Cys His Ser His Phe Gln Asn Ile Phe 
        195                 200                 205


Trp Ser Ser Leu Met Tyr Leu Ser Tyr Leu Val Leu Phe Cys His Phe 
    210                 215                 220


Phe Phe Glu Ala Tyr Ile Gly Lys Met Arg Lys Thr Thr Lys Ala Glu 
225                 230                 235                 240


<210>  2556
<211>  2945
<212>  DNA
<213>  Homo sapiens

<400>  2556
aatcgcacga gggggaggag atttccctgt agacgagtaa aaagggtgat ggacaaacgt     60

gcgggcacta agaccgcaag gcattcattt cctcctacgg tggatgcgga cgccgggagg    120

aggagagccc cagagagagg agctgggagc ggaggcgcag agaacacgta gcgactccga    180

agatcagccc caatgaacat gtcagtgttg actttacaag aatatgaatt cgaaaagcag    240

ttcaacgaga atgaagccat ccaatggatg caggaaaact ggaagaaatc tttcctgttt    300

tctgctctgt atgctgcctt tatattcggt ggtcggcacc taatgaataa acgagcaaag    360

tttgaactga ggaagccatt agtgctctgg tctctgaccc ttgcagtctt cagtatattc    420

ggtgctcttc gaactggtgc ttatatggtg tacattttga tgaccaaagg cctgaagcag    480

tcagtttgtg accagggttt ttacaatgga cctgtcagca aattctgggc ttatgcattt    540

gtgctaagca aagcacccga actaggagat acaatattca ttattctgag gaagcagaag    600

ctgatcttcc tgcactggta tcaccacatc actgtgctcc tgtactcttg gtactcctac    660

aaagacatgg ttgccggggg aggttggttc atgactatga actatggcgt gcacgccgtg    720

atgtactctt actatgcctt gcgggcggca ggtttccgag tctcccggaa gtttgccatg    780

ttcatcacct tgtcccagat cactcagatg ctgatgggct gtgtggttaa ctacctggtc    840

ttctgctgga tgcagcatga ccagtgtcac tctcactttc agaacatctt ctggtcctca    900

ctcatgtacc tcagctacct tgtgctcttc tgccatttct tctttgaggc ctacatcggc    960

aaaatgagga aaacaacgaa agctgaatag tgttggaact gaggaggaag ccatagctca   1020

gggtcatcaa gaaaaataat agacaaaaga aaatggcaca aggaatcaca cgtggtgcag   1080

ctaaaacaaa acaaaacatg agcaaacaca aaacccaagg cagcttaggg ataattaggt   1140

tgatttaacc cagtaagttt atgatccttt tagggtgagg actcactgag tgcacctcca   1200

tctccaagca ctgctgctgg aagaccccat tccctcttta tctatcaact ctaggacaag   1260

ggagaacaaa agcaagccag aagcagagga gactaatcaa aggcaaacaa aggctattaa   1320

cacataggaa aaaatgtatt tactaagtgt cacatttctc taagatgaaa gatttttact   1380

ctagaaactg tgcgagcaca acacacacaa tcctttctaa ctttatggac actaaactgg   1440

agccaataga aaagacaaaa atgaaagaga cacagggtgt atatctagaa cgataatgct   1500

tttgcagaaa ctaaagcctt tttaagaaat gccagctgct gtagacccca tgagaaaaga   1560

tgtcttaatc atccttatga aaacagatgt aaacaactat atttcaacta acttcatctt   1620

cactgcatag cctcaggcta gtgagtttgc caaaaccaaa gggggtgaat acttccccaa   1680

gattcttcct gggaggatgg aaacagtgca gcccaggtcc catgggggca gctccatccc   1740

agagcatttc tgatagttga actgtaattt ctactcttaa gtgagatatg aagcattatc   1800

cttttgttca gttgccccgg gcttttgaac agaagagtaa atacagaatt gaaaaagata   1860

aacactcaac caaacaatgt gaaaacgggt tctgtagtat ttgtaaaaag gcccggccca   1920

ggaccactgt gagctggaaa agggagaaag gcagtgggaa aagaggtgag ccgaagatca   1980

attcgacaga cagatggtgt gtatgcccct ccctgtttga cttcacacac actcataact   2040

ttccaaatga aaccccacag tatagcgcat attttcgata tttttgtgaa ttccaaaagg   2100

aaatcacagg gctgttcgaa atattggggg aacactgtgt ttctgcatca tctgcatttg   2160

ctccccaagc aatgtagagg tgtttaaagg gccctctgct ggctgagtgg caatactaca   2220

acaaacttca aggcaagttt ggctgaaaac agttgacaac aaagggcccc catacactta   2280

tccctcaaat tttaagtgat atgaaatact tgtcatgtct ttggccaaat cagaagatat   2340

tcatcctgct tcaagtcagc ttcagaaatg ttttaaaagg gactttagct ctggaactca   2400

aaatcaattt attaagagcc atattcttta aaaaaaaaaa gctggataat attctctgta   2460

atatttcagt cctttacaag ccaaatacat gtgtcaatgt ttctagtatt tcaaagaagc   2520

aattatgtaa agttgttcaa tgtgacataa tagtattata attggttaag tagcttaatg   2580

attaggcaaa ctagatgaaa agattagggg cttccacact gcatagatta cacgcacata   2640

gccacgcata cacacacaga cacacagatg tggggtacac tgaacttcaa agcccaaatg   2700

aatagaaaca cattttctgg ctagcagaaa aaaacaaaac aaaactgttg tttctctttc   2760

ttgctttgag agtgtacagt aaaagggatt ttttcgaatt atttttatat tattttagct   2820

ttaattgtgc tgtcgttcat gaaacagagc tgctctgctt ttctgtcaga gatggcaagg   2880

gctttttcag catctcgttt atgtgtggaa tttaaaaaga ataaagtttt attccattct   2940

gtgtg                                                               2945


<210>  2557
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  2557

Met Asn Met Ser Val Leu Thr Leu Gln Glu Tyr Glu Phe Glu Lys Gln 
1               5                   10                  15


Phe Asn Glu Asn Glu Ala Ile Gln Trp Met Gln Glu Asn Trp Lys Lys 
            20                  25                  30


Ser Phe Leu Phe Ser Ala Leu Tyr Ala Ala Phe Ile Phe Gly Gly Arg 
        35                  40                  45


His Leu Met Asn Lys Arg Ala Lys Phe Glu Leu Arg Lys Pro Leu Val 
    50                  55                  60


Leu Trp Ser Leu Thr Leu Ala Val Phe Ser Ile Phe Gly Ala Leu Arg 
65                  70                  75                  80


Thr Gly Ala Tyr Met Val Tyr Ile Leu Met Thr Lys Gly Leu Lys Gln 
                85                  90                  95


Ser Val Cys Asp Gln Gly Phe Tyr Asn Gly Pro Val Ser Lys Phe Trp 
            100                 105                 110


Ala Tyr Ala Phe Val Leu Ser Lys Ala Pro Glu Leu Gly Asp Thr Ile 
        115                 120                 125


Phe Ile Ile Leu Arg Lys Gln Lys Leu Ile Phe Leu His Trp Tyr His 
    130                 135                 140


His Ile Thr Val Leu Leu Tyr Ser Trp Tyr Ser Tyr Lys Asp Met Val 
145                 150                 155                 160


Ala Gly Gly Gly Trp Phe Met Thr Met Asn Tyr Gly Val His Ala Val 
                165                 170                 175


Met Tyr Ser Tyr Tyr Ala Leu Arg Ala Ala Gly Phe Arg Val Ser Arg 
            180                 185                 190


Lys Phe Ala Met Phe Ile Thr Leu Ser Gln Ile Thr Gln Met Leu Met 
        195                 200                 205


Gly Cys Val Val Asn Tyr Leu Val Phe Cys Trp Met Gln His Asp Gln 
    210                 215                 220


Cys His Ser His Phe Gln Asn Ile Phe Trp Ser Ser Leu Met Tyr Leu 
225                 230                 235                 240


Ser Tyr Leu Val Leu Phe Cys His Phe Phe Phe Glu Ala Tyr Ile Gly 
                245                 250                 255


Lys Met Arg Lys Thr Thr Lys Ala Glu 
            260                 265


<210>  2558
<211>  3298
<212>  DNA
<213>  Homo sapiens

<400>  2558
gcaagctgaa acttcattca aagcaaggcg gcccacgagg ttgggcttag gggatctgga     60

tgacctccag gccacttcct ttctctctgc gcccttcccc cactcttcca accaccttcg    120

ctgtaaacaa aactgtcccc cccgggcgga gagaggtcgc gctctttcgc acactccctc    180

gccaagggtt aatttctcaa atcgcacgag ggggaggaga tttccctgta gacgagtaaa    240

aagggtgatg gacaaacgtg cgggcactaa gaccgcaagg cattcatttc ctcctacggt    300

ggatgcggac gccgggagga ggagagcccc agagagagga gctgggagcg gaggcgcagg    360

caatgctcag ccctggatgt agctgagagg ctgggagaag agacgaccgc tggagaccga    420

gcggcgtggg gaagacctag gggggtgggt gggggaagca gacaggagaa cactcgaaat    480

caagcgcttt acagattatt ttattttgta tagagaacac gtagcgactc cgaagatcag    540

ccccaatgaa catgtcagtg ttgactttac aagaatatga attcgaaaag cagttcaacg    600

agaatgaagc catccaatgg atgcaggaaa actggaagaa atctttcctg ttttctgctc    660

tgtatgctgc ctttatattc ggtggtcggc acctaatgaa taaacgagca aagtttgaac    720

tgaggaagcc attagtgctc tggtctctga cccttgcagt cttcagtata ttcggtgctc    780

ttcgaactgg tgcttatatg gtgtacattt tgatgaccaa aggcctgaag cagtcagttt    840

gtgaccaggg tttttacaat ggacctgtca gcaaattctg ggcttatgca tttgtgctaa    900

gcaaagcacc cgaactagga gatacaatat tcattattct gaggaagcag aagctgatct    960

tcctgcactg gtatcaccac atcactgtgc tcctgtactc ttggtactcc tacaaagaca   1020

tggttgccgg gggaggttgg ttcatgacta tgaactatgg cgtgcacgcc gtgatgtact   1080

cttactatgc cttgcgggcg gcaggtttcc gagtctcccg gaagtttgcc atgttcatca   1140

ccttgtccca gatcactcag atgctgatgg gctgtgtggt taactacctg gtcttctgct   1200

ggatgcagca tgaccagtgt cactctcact ttcagaacat cttctggtcc tcactcatgt   1260

acctcagcta ccttgtgctc ttctgccatt tcttctttga ggcctacatc ggcaaaatga   1320

ggaaaacaac gaaagctgaa tagtgttgga actgaggagg aagccatagc tcagggtcat   1380

caagaaaaat aatagacaaa agaaaatggc acaaggaatc acacgtggtg cagctaaaac   1440

aaaacaaaac atgagcaaac acaaaaccca aggcagctta gggataatta ggttgattta   1500

acccagtaag tttatgatcc ttttagggtg aggactcact gagtgcacct ccatctccaa   1560

gcactgctgc tggaagaccc cattccctct ttatctatca actctaggac aagggagaac   1620

aaaagcaagc cagaagcaga ggagactaat caaaggcaaa caaaggctat taacacatag   1680

gaaaaaatgt atttactaag tgtcacattt ctctaagatg aaagattttt actctagaaa   1740

ctgtgcgagc acaacacaca caatcctttc taactttatg gacactaaac tggagccaat   1800

agaaaagaca aaaatgaaag agacacaggg tgtatatcta gaacgataat gcttttgcag   1860

aaactaaagc ctttttaaga aatgccagct gctgtagacc ccatgagaaa agatgtctta   1920

atcatcctta tgaaaacaga tgtaaacaac tatatttcaa ctaacttcat cttcactgca   1980

tagcctcagg ctagtgagtt tgccaaaacc aaagggggtg aatacttccc caagattctt   2040

cctgggagga tggaaacagt gcagcccagg tcccatgggg gcagctccat cccagagcat   2100

ttctgatagt tgaactgtaa tttctactct taagtgagat atgaagcatt atccttttgt   2160

tcagttgccc cgggcttttg aacagaagag taaatacaga attgaaaaag ataaacactc   2220

aaccaaacaa tgtgaaaacg ggttctgtag tatttgtaaa aaggcccggc ccaggaccac   2280

tgtgagctgg aaaagggaga aaggcagtgg gaaaagaggt gagccgaaga tcaattcgac   2340

agacagatgg tgtgtatgcc cctccctgtt tgacttcaca cacactcata actttccaaa   2400

tgaaacccca cagtatagcg catattttcg atatttttgt gaattccaaa aggaaatcac   2460

agggctgttc gaaatattgg gggaacactg tgtttctgca tcatctgcat ttgctcccca   2520

agcaatgtag aggtgtttaa agggccctct gctggctgag tggcaatact acaacaaact   2580

tcaaggcaag tttggctgaa aacagttgac aacaaagggc ccccatacac ttatccctca   2640

aattttaagt gatatgaaat acttgtcatg tctttggcca aatcagaaga tattcatcct   2700

gcttcaagtc agcttcagaa atgttttaaa agggacttta gctctggaac tcaaaatcaa   2760

tttattaaga gccatattct ttaaaaaaaa aaagctggat aatattctct gtaatatttc   2820

agtcctttac aagccaaata catgtgtcaa tgtttctagt atttcaaaga agcaattatg   2880

taaagttgtt caatgtgaca taatagtatt ataattggtt aagtagctta atgattaggc   2940

aaactagatg aaaagattag gggcttccac actgcataga ttacacgcac atagccacgc   3000

atacacacac agacacacag atgtggggta cactgaactt caaagcccaa atgaatagaa   3060

acacattttc tggctagcag aaaaaaacaa aacaaaactg ttgtttctct ttcttgcttt   3120

gagagtgtac agtaaaaggg attttttcga attattttta tattatttta gctttaattg   3180

tgctgtcgtt catgaaacag agctgctctg cttttctgtc agagatggca agggcttttt   3240

cagcatctcg tttatgtgtg gaatttaaaa agaataaagt tttattccat tctgtgtg     3298


<210>  2559
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  2559

Met Asn Met Ser Val Leu Thr Leu Gln Glu Tyr Glu Phe Glu Lys Gln 
1               5                   10                  15


Phe Asn Glu Asn Glu Ala Ile Gln Trp Met Gln Glu Asn Trp Lys Lys 
            20                  25                  30


Ser Phe Leu Phe Ser Ala Leu Tyr Ala Ala Phe Ile Phe Gly Gly Arg 
        35                  40                  45


His Leu Met Asn Lys Arg Ala Lys Phe Glu Leu Arg Lys Pro Leu Val 
    50                  55                  60


Leu Trp Ser Leu Thr Leu Ala Val Phe Ser Ile Phe Gly Ala Leu Arg 
65                  70                  75                  80


Thr Gly Ala Tyr Met Val Tyr Ile Leu Met Thr Lys Gly Leu Lys Gln 
                85                  90                  95


Ser Val Cys Asp Gln Gly Phe Tyr Asn Gly Pro Val Ser Lys Phe Trp 
            100                 105                 110


Ala Tyr Ala Phe Val Leu Ser Lys Ala Pro Glu Leu Gly Asp Thr Ile 
        115                 120                 125


Phe Ile Ile Leu Arg Lys Gln Lys Leu Ile Phe Leu His Trp Tyr His 
    130                 135                 140


His Ile Thr Val Leu Leu Tyr Ser Trp Tyr Ser Tyr Lys Asp Met Val 
145                 150                 155                 160


Ala Gly Gly Gly Trp Phe Met Thr Met Asn Tyr Gly Val His Ala Val 
                165                 170                 175


Met Tyr Ser Tyr Tyr Ala Leu Arg Ala Ala Gly Phe Arg Val Ser Arg 
            180                 185                 190


Lys Phe Ala Met Phe Ile Thr Leu Ser Gln Ile Thr Gln Met Leu Met 
        195                 200                 205


Gly Cys Val Val Asn Tyr Leu Val Phe Cys Trp Met Gln His Asp Gln 
    210                 215                 220


Cys His Ser His Phe Gln Asn Ile Phe Trp Ser Ser Leu Met Tyr Leu 
225                 230                 235                 240


Ser Tyr Leu Val Leu Phe Cys His Phe Phe Phe Glu Ala Tyr Ile Gly 
                245                 250                 255


Lys Met Arg Lys Thr Thr Lys Ala Glu 
            260                 265


<210>  2560
<211>  2955
<212>  DNA
<213>  Homo sapiens

<400>  2560
gtattccctt cactggtgat ctcaacgtag atttgcccgg agttctcttg caagagagct     60

ggcaggtttt actatttccc aatcgtttac tcgccaagct ctcgggtcca cgcgccgcgg    120

ggatgcgccc tgcaagctga aacttcattc aaagcaaggc ggcccacgag agaacacgta    180

gcgactccga agatcagccc caatgaacat gtcagtgttg actttacaag aatatgaatt    240

cgaaaagcag ttcaacgaga atgaagccat ccaatggatg caggaaaact ggaagaaatc    300

tttcctgttt tctgctctgt atgctgcctt tatattcggt ggtcggcacc taatgaataa    360

acgagcaaag tttgaactga ggaagccatt agtgctctgg tctctgaccc ttgcagtctt    420

cagtatattc ggtgctcttc gaactggtgc ttatatggtg tacattttga tgaccaaagg    480

cctgaagcag tcagtttgtg accagggttt ttacaatgga cctgtcagca aattctgggc    540

ttatgcattt gtgctaagca aagcacccga actaggagat acaatattca ttattctgag    600

gaagcagaag ctgatcttcc tgcactggta tcaccacatc actgtgctcc tgtactcttg    660

gtactcctac aaagacatgg ttgccggggg aggttggttc atgactatga actatggcgt    720

gcacgccgtg atgtactctt actatgcctt gcgggcggca ggtttccgag tctcccggaa    780

gtttgccatg ttcatcacct tgtcccagat cactcagatg ctgatgggct gtgtggttaa    840

ctacctggtc ttctgctgga tgcagcatga ccagtgtcac tctcactttc agaacatctt    900

ctggtcctca ctcatgtacc tcagctacct tgtgctcttc tgccatttct tctttgaggc    960

ctacatcggc aaaatgagga aaacaacgaa agctgaatag tgttggaact gaggaggaag   1020

ccatagctca gggtcatcaa gaaaaataat agacaaaaga aaatggcaca aggaatcaca   1080

cgtggtgcag ctaaaacaaa acaaaacatg agcaaacaca aaacccaagg cagcttaggg   1140

ataattaggt tgatttaacc cagtaagttt atgatccttt tagggtgagg actcactgag   1200

tgcacctcca tctccaagca ctgctgctgg aagaccccat tccctcttta tctatcaact   1260

ctaggacaag ggagaacaaa agcaagccag aagcagagga gactaatcaa aggcaaacaa   1320

aggctattaa cacataggaa aaaatgtatt tactaagtgt cacatttctc taagatgaaa   1380

gatttttact ctagaaactg tgcgagcaca acacacacaa tcctttctaa ctttatggac   1440

actaaactgg agccaataga aaagacaaaa atgaaagaga cacagggtgt atatctagaa   1500

cgataatgct tttgcagaaa ctaaagcctt tttaagaaat gccagctgct gtagacccca   1560

tgagaaaaga tgtcttaatc atccttatga aaacagatgt aaacaactat atttcaacta   1620

acttcatctt cactgcatag cctcaggcta gtgagtttgc caaaaccaaa gggggtgaat   1680

acttccccaa gattcttcct gggaggatgg aaacagtgca gcccaggtcc catgggggca   1740

gctccatccc agagcatttc tgatagttga actgtaattt ctactcttaa gtgagatatg   1800

aagcattatc cttttgttca gttgccccgg gcttttgaac agaagagtaa atacagaatt   1860

gaaaaagata aacactcaac caaacaatgt gaaaacgggt tctgtagtat ttgtaaaaag   1920

gcccggccca ggaccactgt gagctggaaa agggagaaag gcagtgggaa aagaggtgag   1980

ccgaagatca attcgacaga cagatggtgt gtatgcccct ccctgtttga cttcacacac   2040

actcataact ttccaaatga aaccccacag tatagcgcat attttcgata tttttgtgaa   2100

ttccaaaagg aaatcacagg gctgttcgaa atattggggg aacactgtgt ttctgcatca   2160

tctgcatttg ctccccaagc aatgtagagg tgtttaaagg gccctctgct ggctgagtgg   2220

caatactaca acaaacttca aggcaagttt ggctgaaaac agttgacaac aaagggcccc   2280

catacactta tccctcaaat tttaagtgat atgaaatact tgtcatgtct ttggccaaat   2340

cagaagatat tcatcctgct tcaagtcagc ttcagaaatg ttttaaaagg gactttagct   2400

ctggaactca aaatcaattt attaagagcc atattcttta aaaaaaaaaa gctggataat   2460

attctctgta atatttcagt cctttacaag ccaaatacat gtgtcaatgt ttctagtatt   2520

tcaaagaagc aattatgtaa agttgttcaa tgtgacataa tagtattata attggttaag   2580

tagcttaatg attaggcaaa ctagatgaaa agattagggg cttccacact gcatagatta   2640

cacgcacata gccacgcata cacacacaga cacacagatg tggggtacac tgaacttcaa   2700

agcccaaatg aatagaaaca cattttctgg ctagcagaaa aaaacaaaac aaaactgttg   2760

tttctctttc ttgctttgag agtgtacagt aaaagggatt ttttcgaatt atttttatat   2820

tattttagct ttaattgtgc tgtcgttcat gaaacagagc tgctctgctt ttctgtcaga   2880

gatggcaagg gctttttcag catctcgttt atgtgtggaa tttaaaaaga ataaagtttt   2940

attccattct gtgtg                                                    2955


<210>  2561
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  2561

Met Asn Met Ser Val Leu Thr Leu Gln Glu Tyr Glu Phe Glu Lys Gln 
1               5                   10                  15


Phe Asn Glu Asn Glu Ala Ile Gln Trp Met Gln Glu Asn Trp Lys Lys 
            20                  25                  30


Ser Phe Leu Phe Ser Ala Leu Tyr Ala Ala Phe Ile Phe Gly Gly Arg 
        35                  40                  45


His Leu Met Asn Lys Arg Ala Lys Phe Glu Leu Arg Lys Pro Leu Val 
    50                  55                  60


Leu Trp Ser Leu Thr Leu Ala Val Phe Ser Ile Phe Gly Ala Leu Arg 
65                  70                  75                  80


Thr Gly Ala Tyr Met Val Tyr Ile Leu Met Thr Lys Gly Leu Lys Gln 
                85                  90                  95


Ser Val Cys Asp Gln Gly Phe Tyr Asn Gly Pro Val Ser Lys Phe Trp 
            100                 105                 110


Ala Tyr Ala Phe Val Leu Ser Lys Ala Pro Glu Leu Gly Asp Thr Ile 
        115                 120                 125


Phe Ile Ile Leu Arg Lys Gln Lys Leu Ile Phe Leu His Trp Tyr His 
    130                 135                 140


His Ile Thr Val Leu Leu Tyr Ser Trp Tyr Ser Tyr Lys Asp Met Val 
145                 150                 155                 160


Ala Gly Gly Gly Trp Phe Met Thr Met Asn Tyr Gly Val His Ala Val 
                165                 170                 175


Met Tyr Ser Tyr Tyr Ala Leu Arg Ala Ala Gly Phe Arg Val Ser Arg 
            180                 185                 190


Lys Phe Ala Met Phe Ile Thr Leu Ser Gln Ile Thr Gln Met Leu Met 
        195                 200                 205


Gly Cys Val Val Asn Tyr Leu Val Phe Cys Trp Met Gln His Asp Gln 
    210                 215                 220


Cys His Ser His Phe Gln Asn Ile Phe Trp Ser Ser Leu Met Tyr Leu 
225                 230                 235                 240


Ser Tyr Leu Val Leu Phe Cys His Phe Phe Phe Glu Ala Tyr Ile Gly 
                245                 250                 255


Lys Met Arg Lys Thr Thr Lys Ala Glu 
            260                 265


<210>  2562
<211>  2894
<212>  DNA
<213>  Homo sapiens

<400>  2562
ctctcgccta tccactatcc tcacactcag catcccctgt ctgtacgaga ttaaggagct     60

ctgccgtccg cagggcctgg agaacacgta gcgactccga agatcagccc caatgaacat    120

gtcagtgttg actttacaag aatatgaatt cgaaaagcag ttcaacgaga atgaagccat    180

ccaatggatg caggaaaact ggaagaaatc tttcctgttt tctgctctgt atgctgcctt    240

tatattcggt ggtcggcacc taatgaataa acgagcaaag tttgaactga ggaagccatt    300

agtgctctgg tctctgaccc ttgcagtctt caggtgctat aacaacttga aacagctgac    360

attatattcg gtgctcttcg aactggtgct tatatggtgt acattttgat gaccaaaggc    420

ctgaagcagt cagtttgtga ccagggtttt tacaatggac ctgtcagcaa attctgggct    480

tatgcatttg tgctaagcaa agcacccgaa ctaggagata caatattcat tattctgagg    540

aagcagaagc tgatcttcct gcactggtat caccacatca ctgtgctcct gtactcttgg    600

tactcctaca aagacatggt tgccggggga ggttggttca tgactatgaa ctatggcgtg    660

cacgccgtga tgtactctta ctatgccttg cgggcggcag gtttccgagt ctcccggaag    720

tttgccatgt tcatcacctt gtcccagatc actcagatgc tgatgggctg tgtggttaac    780

tacctggtct tctgctggat gcagcatgac cagtgtcact ctcactttca gaacatcttc    840

tggtcctcac tcatgtacct cagctacctt gtgctcttct gccatttctt ctttgaggcc    900

tacatcggca aaatgaggaa aacaacgaaa gctgaatagt gttggaactg aggaggaagc    960

catagctcag ggtcatcaag aaaaataata gacaaaagaa aatggcacaa ggaatcacac   1020

gtggtgcagc taaaacaaaa caaaacatga gcaaacacaa aacccaaggc agcttaggga   1080

taattaggtt gatttaaccc agtaagttta tgatcctttt agggtgagga ctcactgagt   1140

gcacctccat ctccaagcac tgctgctgga agaccccatt ccctctttat ctatcaactc   1200

taggacaagg gagaacaaaa gcaagccaga agcagaggag actaatcaaa ggcaaacaaa   1260

ggctattaac acataggaaa aaatgtattt actaagtgtc acatttctct aagatgaaag   1320

atttttactc tagaaactgt gcgagcacaa cacacacaat cctttctaac tttatggaca   1380

ctaaactgga gccaatagaa aagacaaaaa tgaaagagac acagggtgta tatctagaac   1440

gataatgctt ttgcagaaac taaagccttt ttaagaaatg ccagctgctg tagaccccat   1500

gagaaaagat gtcttaatca tccttatgaa aacagatgta aacaactata tttcaactaa   1560

cttcatcttc actgcatagc ctcaggctag tgagtttgcc aaaaccaaag ggggtgaata   1620

cttccccaag attcttcctg ggaggatgga aacagtgcag cccaggtccc atgggggcag   1680

ctccatccca gagcatttct gatagttgaa ctgtaatttc tactcttaag tgagatatga   1740

agcattatcc ttttgttcag ttgccccggg cttttgaaca gaagagtaaa tacagaattg   1800

aaaaagataa acactcaacc aaacaatgtg aaaacgggtt ctgtagtatt tgtaaaaagg   1860

cccggcccag gaccactgtg agctggaaaa gggagaaagg cagtgggaaa agaggtgagc   1920

cgaagatcaa ttcgacagac agatggtgtg tatgcccctc cctgtttgac ttcacacaca   1980

ctcataactt tccaaatgaa accccacagt atagcgcata ttttcgatat ttttgtgaat   2040

tccaaaagga aatcacaggg ctgttcgaaa tattggggga acactgtgtt tctgcatcat   2100

ctgcatttgc tccccaagca atgtagaggt gtttaaaggg ccctctgctg gctgagtggc   2160

aatactacaa caaacttcaa ggcaagtttg gctgaaaaca gttgacaaca aagggccccc   2220

atacacttat ccctcaaatt ttaagtgata tgaaatactt gtcatgtctt tggccaaatc   2280

agaagatatt catcctgctt caagtcagct tcagaaatgt tttaaaaggg actttagctc   2340

tggaactcaa aatcaattta ttaagagcca tattctttaa aaaaaaaaag ctggataata   2400

ttctctgtaa tatttcagtc ctttacaagc caaatacatg tgtcaatgtt tctagtattt   2460

caaagaagca attatgtaaa gttgttcaat gtgacataat agtattataa ttggttaagt   2520

agcttaatga ttaggcaaac tagatgaaaa gattaggggc ttccacactg catagattac   2580

acgcacatag ccacgcatac acacacagac acacagatgt ggggtacact gaacttcaaa   2640

gcccaaatga atagaaacac attttctggc tagcagaaaa aaacaaaaca aaactgttgt   2700

ttctctttct tgctttgaga gtgtacagta aaagggattt tttcgaatta tttttatatt   2760

attttagctt taattgtgct gtcgttcatg aaacagagct gctctgcttt tctgtcagag   2820

atggcaaggg ctttttcagc atctcgttta tgtgtggaat ttaaaaagaa taaagtttta   2880

ttccattctg tgtg                                                     2894


<210>  2563
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  2563

Met Val Tyr Ile Leu Met Thr Lys Gly Leu Lys Gln Ser Val Cys Asp 
1               5                   10                  15


Gln Gly Phe Tyr Asn Gly Pro Val Ser Lys Phe Trp Ala Tyr Ala Phe 
            20                  25                  30


Val Leu Ser Lys Ala Pro Glu Leu Gly Asp Thr Ile Phe Ile Ile Leu 
        35                  40                  45


Arg Lys Gln Lys Leu Ile Phe Leu His Trp Tyr His His Ile Thr Val 
    50                  55                  60


Leu Leu Tyr Ser Trp Tyr Ser Tyr Lys Asp Met Val Ala Gly Gly Gly 
65                  70                  75                  80


Trp Phe Met Thr Met Asn Tyr Gly Val His Ala Val Met Tyr Ser Tyr 
                85                  90                  95


Tyr Ala Leu Arg Ala Ala Gly Phe Arg Val Ser Arg Lys Phe Ala Met 
            100                 105                 110


Phe Ile Thr Leu Ser Gln Ile Thr Gln Met Leu Met Gly Cys Val Val 
        115                 120                 125


Asn Tyr Leu Val Phe Cys Trp Met Gln His Asp Gln Cys His Ser His 
    130                 135                 140


Phe Gln Asn Ile Phe Trp Ser Ser Leu Met Tyr Leu Ser Tyr Leu Val 
145                 150                 155                 160


Leu Phe Cys His Phe Phe Phe Glu Ala Tyr Ile Gly Lys Met Arg Lys 
                165                 170                 175


Thr Thr Lys Ala Glu 
            180


<210>  2564
<211>  2885
<212>  DNA
<213>  Homo sapiens

<400>  2564
ccacttccgg ctactagcct ctctcgccta tccactatcc tcacactcag catcccctgt     60

ctgtacgaga ttaaggagct ctgccgtccg cagggcctgg agaacacgta gcgactccga    120

agatcagccc caatgaacat gtcagtgttg actttacaag aatatgaatt cgaaaagcag    180

ttcaacgaga atgaagccat ccaatggatg caggaaaact ggaagaaatc tttcctgttt    240

tctgctctgt atgctgcctt tatattcggt ggtcggcacc taatgaataa acgagcaaag    300

tttgaactga ggaagccatt agtgctctgg tctctgaccc ttgcagtctt cagtatattc    360

ggtgctcttc gaactggtgc ttatatggtg tacattttga tgaccaaagg cctgaagcag    420

tcagtttgtg accagggttt ttacaatgga cctgtcagca aattctgggc ttatgcattt    480

gtgctaagca aagcacccga actaggagat acaatattca ttattctgag gaagcagaag    540

ctgatcttcc tgcactggta tcaccacatc actgtgctcc tgtactcttg gtactcctac    600

aaagacatgg ttgccggggg aggttggttc atgactatga actatggcgt gcacgccgtg    660

atgtactctt actatgcctt gcgggcggca ggtttccgag tctcccggaa gtttgccatg    720

ttcatcacct tgtcccagat cactcagatg ctgatgggct gtgtggttaa ctacctggtc    780

ttctgctgga tgcagcatga ccagtgtcac tctcactttc agaacatctt ctggtcctca    840

ctcatgtacc tcagctacct tgtgctcttc tgccatttct tctttgaggc ctacatcggc    900

aaaatgagga aaacaacgaa agctgaatag tgttggaact gaggaggaag ccatagctca    960

gggtcatcaa gaaaaataat agacaaaaga aaatggcaca aggaatcaca cgtggtgcag   1020

ctaaaacaaa acaaaacatg agcaaacaca aaacccaagg cagcttaggg ataattaggt   1080

tgatttaacc cagtaagttt atgatccttt tagggtgagg actcactgag tgcacctcca   1140

tctccaagca ctgctgctgg aagaccccat tccctcttta tctatcaact ctaggacaag   1200

ggagaacaaa agcaagccag aagcagagga gactaatcaa aggcaaacaa aggctattaa   1260

cacataggaa aaaatgtatt tactaagtgt cacatttctc taagatgaaa gatttttact   1320

ctagaaactg tgcgagcaca acacacacaa tcctttctaa ctttatggac actaaactgg   1380

agccaataga aaagacaaaa atgaaagaga cacagggtgt atatctagaa cgataatgct   1440

tttgcagaaa ctaaagcctt tttaagaaat gccagctgct gtagacccca tgagaaaaga   1500

tgtcttaatc atccttatga aaacagatgt aaacaactat atttcaacta acttcatctt   1560

cactgcatag cctcaggcta gtgagtttgc caaaaccaaa gggggtgaat acttccccaa   1620

gattcttcct gggaggatgg aaacagtgca gcccaggtcc catgggggca gctccatccc   1680

agagcatttc tgatagttga actgtaattt ctactcttaa gtgagatatg aagcattatc   1740

cttttgttca gttgccccgg gcttttgaac agaagagtaa atacagaatt gaaaaagata   1800

aacactcaac caaacaatgt gaaaacgggt tctgtagtat ttgtaaaaag gcccggccca   1860

ggaccactgt gagctggaaa agggagaaag gcagtgggaa aagaggtgag ccgaagatca   1920

attcgacaga cagatggtgt gtatgcccct ccctgtttga cttcacacac actcataact   1980

ttccaaatga aaccccacag tatagcgcat attttcgata tttttgtgaa ttccaaaagg   2040

aaatcacagg gctgttcgaa atattggggg aacactgtgt ttctgcatca tctgcatttg   2100

ctccccaagc aatgtagagg tgtttaaagg gccctctgct ggctgagtgg caatactaca   2160

acaaacttca aggcaagttt ggctgaaaac agttgacaac aaagggcccc catacactta   2220

tccctcaaat tttaagtgat atgaaatact tgtcatgtct ttggccaaat cagaagatat   2280

tcatcctgct tcaagtcagc ttcagaaatg ttttaaaagg gactttagct ctggaactca   2340

aaatcaattt attaagagcc atattcttta aaaaaaaaaa gctggataat attctctgta   2400

atatttcagt cctttacaag ccaaatacat gtgtcaatgt ttctagtatt tcaaagaagc   2460

aattatgtaa agttgttcaa tgtgacataa tagtattata attggttaag tagcttaatg   2520

attaggcaaa ctagatgaaa agattagggg cttccacact gcatagatta cacgcacata   2580

gccacgcata cacacacaga cacacagatg tggggtacac tgaacttcaa agcccaaatg   2640

aatagaaaca cattttctgg ctagcagaaa aaaacaaaac aaaactgttg tttctctttc   2700

ttgctttgag agtgtacagt aaaagggatt ttttcgaatt atttttatat tattttagct   2760

ttaattgtgc tgtcgttcat gaaacagagc tgctctgctt ttctgtcaga gatggcaagg   2820

gctttttcag catctcgttt atgtgtggaa tttaaaaaga ataaagtttt attccattct   2880

gtgtg                                                               2885


<210>  2565
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  2565

Met Asn Met Ser Val Leu Thr Leu Gln Glu Tyr Glu Phe Glu Lys Gln 
1               5                   10                  15


Phe Asn Glu Asn Glu Ala Ile Gln Trp Met Gln Glu Asn Trp Lys Lys 
            20                  25                  30


Ser Phe Leu Phe Ser Ala Leu Tyr Ala Ala Phe Ile Phe Gly Gly Arg 
        35                  40                  45


His Leu Met Asn Lys Arg Ala Lys Phe Glu Leu Arg Lys Pro Leu Val 
    50                  55                  60


Leu Trp Ser Leu Thr Leu Ala Val Phe Ser Ile Phe Gly Ala Leu Arg 
65                  70                  75                  80


Thr Gly Ala Tyr Met Val Tyr Ile Leu Met Thr Lys Gly Leu Lys Gln 
                85                  90                  95


Ser Val Cys Asp Gln Gly Phe Tyr Asn Gly Pro Val Ser Lys Phe Trp 
            100                 105                 110


Ala Tyr Ala Phe Val Leu Ser Lys Ala Pro Glu Leu Gly Asp Thr Ile 
        115                 120                 125


Phe Ile Ile Leu Arg Lys Gln Lys Leu Ile Phe Leu His Trp Tyr His 
    130                 135                 140


His Ile Thr Val Leu Leu Tyr Ser Trp Tyr Ser Tyr Lys Asp Met Val 
145                 150                 155                 160


Ala Gly Gly Gly Trp Phe Met Thr Met Asn Tyr Gly Val His Ala Val 
                165                 170                 175


Met Tyr Ser Tyr Tyr Ala Leu Arg Ala Ala Gly Phe Arg Val Ser Arg 
            180                 185                 190


Lys Phe Ala Met Phe Ile Thr Leu Ser Gln Ile Thr Gln Met Leu Met 
        195                 200                 205


Gly Cys Val Val Asn Tyr Leu Val Phe Cys Trp Met Gln His Asp Gln 
    210                 215                 220


Cys His Ser His Phe Gln Asn Ile Phe Trp Ser Ser Leu Met Tyr Leu 
225                 230                 235                 240


Ser Tyr Leu Val Leu Phe Cys His Phe Phe Phe Glu Ala Tyr Ile Gly 
                245                 250                 255


Lys Met Arg Lys Thr Thr Lys Ala Glu 
            260                 265


<210>  2566
<211>  2800
<212>  DNA
<213>  Homo sapiens

<400>  2566
aatcgcacga gggggaggag atttccctgt agacgagtaa aaagggtgat ggacaaacgt     60

gcgggcacta agaccgcaag gcattcattt cctcctacgg tggatgcgga cgccgggagg    120

aggagagccc cagagagagg agctgggagc ggaggcgcag agaacacgta gcgactccga    180

agatcagccc caatgaacat gtcagtgttg actttacaag aatatgaatt cgaaaagcag    240

ttcaacgaga atgaagccat ccaatggatg caggaaaact ggaagaaatc tttcctgttt    300

tctgctctgt atgctgcctt tatattcggt ggtcggcacc taatgaataa acgagcaaag    360

tttgaactga ggaagccatt agtgctctgg tctctgaccc ttgcagtctt cagtatattc    420

ggtgctcttc gaactggtgc ttatatggtg tacattttga tgaccaaagg cctgaagcag    480

tcagtttgtg accagggttt ttacaatgga cctgtcagca aattctgggc ttatgcattt    540

gtgctaagca aagcacccga actaggagat acaatattca ttattctgag gaagcagaag    600

ctgatcttcc tgcactggta tcaccacatc actgtgctcc tgtactcttg gtactcctac    660

aaagacatgg ttgccggggg aggttggttc atgactatga actatggcgt gcacgccgtg    720

atgtactctt actatgcctt gcgggcggca ggtttccgag tctcccggaa gtttgccatg    780

ttcatcacct tgtcccagat cactcagatg ctgatgggct gtgtggttaa ctacctggtc    840

ttctgctgga tgcagcatga ccagtgtcac tctcactttc agaacatctt ctggtcctca    900

ctcatgtacc tcagctacct tgtgctcttc tgccatttct tctttgaggc ctacatcggc    960

aaaatgagga aaacaacgaa agctgaatag tgttggaact gaggaggaag ccatagctca   1020

gggtcatcaa gaaaaataat agacaaaaga aaatggcaca aggaatcaca cgtggtgcag   1080

ctaaaacaaa acaaaacatg agcaaacaca aaacccaagg cagcttaggg ataattaggt   1140

tgatttaacc cagtaagttt atgatccttt tagggtgagg actcactgag tgcacctcca   1200

tctccaagca ctgctgctgg aagaccccat tccctcttta tctatcaact ctaggacaag   1260

ggagaacaaa agcaagccag aagcagagga gactaatcaa aggcaaacaa aggctattaa   1320

cacataggaa aaaatgtatt tactaagtgt cacatttctc taagatgaaa gatttttact   1380

ctagaaactg tgcgagcaca acacacacaa tcctttctaa ctttatggac actaaactgg   1440

agccaataga aaagacaaaa atgaaagaga cacagggtgt atatctagaa cgataatgct   1500

tttgcagaaa ctaaagcctt tttaagaaat gccagctgct gtagacccca tgagaaaaga   1560

tgtcttaatc atccttatga aaacagatgt aaacaactat atttcaacta acttcatctt   1620

cactgcatag cctcaggcta gtgagtttgc caaaaccaaa gggggtgaat acttccccaa   1680

gattcttcct gggaggatgg aaacagtgca gcccaggtcc catgggggca gctccatccc   1740

agagcatttc tgatagttga actgtaattt ctactcttaa gtgagatatg aagcattatc   1800

cttttgttca gttgccccgg gcttttgaac agaagagtaa atacagaatt gaaaaagata   1860

aacactcaac caaacaatgt gaaaacgggt tctgtagtat ttgtaaaaag gcccggccca   1920

ggaccactgt gagctggaaa agggagaaag gcagtgggaa aagaggtgag ccgaagatca   1980

attcgacaga cagatggtgt gtatgcccct ccctgtttga cttcacacac actcataact   2040

ttccaaatga aaccccacag tatagcgcat attttcgata tttttgtgaa ttccaaaagg   2100

aaatcacagg gctgttcgaa atattggggg aacactgtgt ttctgcatca tctgcatttg   2160

ctccccaagc aatgtagagg tgtttaaagg gccctctgct ggctgagtgg caatactaca   2220

acaaacttca aggcaagttt ggctgaaaac agttgacaac aaagggcccc catacactta   2280

tccctcaaat tttaagtgat atgaaatact tgtcatgtct ttggccaaat cagaagatat   2340

tcatcctgct tcaagtcagc ttcagaaatg ttttaaaagg gactttagct ctggaactca   2400

aaatcaattt attaagagcc atattcttta aaaaaaaaaa gctggataat attctctgta   2460

atatttcagt cctttacaag ccaaatacat gtgtcaatgt ttctagtatt tcaaagaagc   2520

aattatgtaa agttgttcaa tgtgacataa tagtattata attggttaag tagcttaatg   2580

attaggcaaa ctagatgaaa agattagggg cttccacact gcatagatta cacgcacata   2640

gccacgcata cacacacaga cacacagatg tggggtacac tgaacttcaa agcccaaatg   2700

aatagaaaca cattttctgg ctagcagaaa aaaacaaaac aaaactgttg tttctctttc   2760

ttgctttgag agtgtacagt aaaagggatt ttttcgaatt                         2800


<210>  2567
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  2567

Met Asn Met Ser Val Leu Thr Leu Gln Glu Tyr Glu Phe Glu Lys Gln 
1               5                   10                  15


Phe Asn Glu Asn Glu Ala Ile Gln Trp Met Gln Glu Asn Trp Lys Lys 
            20                  25                  30


Ser Phe Leu Phe Ser Ala Leu Tyr Ala Ala Phe Ile Phe Gly Gly Arg 
        35                  40                  45


His Leu Met Asn Lys Arg Ala Lys Phe Glu Leu Arg Lys Pro Leu Val 
    50                  55                  60


Leu Trp Ser Leu Thr Leu Ala Val Phe Ser Ile Phe Gly Ala Leu Arg 
65                  70                  75                  80


Thr Gly Ala Tyr Met Val Tyr Ile Leu Met Thr Lys Gly Leu Lys Gln 
                85                  90                  95


Ser Val Cys Asp Gln Gly Phe Tyr Asn Gly Pro Val Ser Lys Phe Trp 
            100                 105                 110


Ala Tyr Ala Phe Val Leu Ser Lys Ala Pro Glu Leu Gly Asp Thr Ile 
        115                 120                 125


Phe Ile Ile Leu Arg Lys Gln Lys Leu Ile Phe Leu His Trp Tyr His 
    130                 135                 140


His Ile Thr Val Leu Leu Tyr Ser Trp Tyr Ser Tyr Lys Asp Met Val 
145                 150                 155                 160


Ala Gly Gly Gly Trp Phe Met Thr Met Asn Tyr Gly Val His Ala Val 
                165                 170                 175


Met Tyr Ser Tyr Tyr Ala Leu Arg Ala Ala Gly Phe Arg Val Ser Arg 
            180                 185                 190


Lys Phe Ala Met Phe Ile Thr Leu Ser Gln Ile Thr Gln Met Leu Met 
        195                 200                 205


Gly Cys Val Val Asn Tyr Leu Val Phe Cys Trp Met Gln His Asp Gln 
    210                 215                 220


Cys His Ser His Phe Gln Asn Ile Phe Trp Ser Ser Leu Met Tyr Leu 
225                 230                 235                 240


Ser Tyr Leu Val Leu Phe Cys His Phe Phe Phe Glu Ala Tyr Ile Gly 
                245                 250                 255


Lys Met Arg Lys Thr Thr Lys Ala Glu 
            260                 265


<210>  2568
<211>  785
<212>  DNA
<213>  Homo sapiens

<400>  2568
actaagaccg caaggcattc atttcctcct acggtggatg cggacgccgg gaggaggaga     60

gccccagaga gaggagctgg gagcggaggc gcaggcaatg ctcagccctg gatgtagctg    120

agaggctggg agaagagacg accgctggag accgagcggc gtggggaaga cctagggggg    180

tgggtggggg aagcagacag gagaacactc gaaatcaagc gctttacaga ttattttatt    240

ttgtatagag aacacgtagc gactccgaag atcagcccca atgaacatgt cagtgttgac    300

tttacaagaa tatgaattcg aaaagcagtt caacgagaat gaagccatcc aatggatgca    360

ggaaaactgg gtgatgtctg cgcgacaggg aaggcgggag agatgccaca gtccagatcg    420

cctacctgtg ctcccctccc ctcccccggt tttcatctag atttgggttt tctcgcttgg    480

cctctcccgc aaccggagtg tgaaaggcag tggagggagg accttgtctc ctgttgcctt    540

taaccctctc ccgcccgccg cccttggccc tggtcctcgc tgtctctcca tccctcgtgt    600

ccttcctttc tccttgcagc gctcctactt caccgtcctc ctctgtctgc cgctcctcag    660

gcggatgccc cctttttagt acccctttcc ccacgcggtt ccctttccgg tttcatagag    720

agaccgggtg ggagggagga ggggacaatg aaaacagtaa taaatgaatg aacccgagcg    780

agtgg                                                                785


<210>  2569
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  2569

Met Asp Ala Gly Lys Leu Gly Asp Val Cys Ala Thr Gly Lys Ala Gly 
1               5                   10                  15


Glu Met Pro Gln Ser Arg Ser Pro Thr Cys Ala Pro Leu Pro Ser Pro 
            20                  25                  30


Gly Phe His Leu Asp Leu Gly Phe Leu Ala Trp Pro Leu Pro Gln Pro 
        35                  40                  45


Glu Cys Glu Arg Gln Trp Arg Glu Asp Leu Val Ser Cys Cys Leu 
    50                  55                  60


<210>  2570
<211>  689
<212>  DNA
<213>  Homo sapiens

<400>  2570
aatcgcacga gggggaggag atttccctgt agacgagtaa aaagggtgat ggacaaacgt     60

gcgggcacta agaccgcaag gcattcattt cctcctacgg tggatgcgga cgccgggagg    120

aggagagccc cagagagagg agctgggagc ggaggcgcag agaacacgta gcgactccga    180

agatcagccc caatgaacat gtcagtgttg actttacaag aatatgaatt cgaaaagcag    240

ttcaacgaga atgaagccat ccaatggatg caggaaaact gggtgatgtc tgcgcgacag    300

ggaaggcggg agagatgcca cagtccagat cgcctacctg tgctcccctc ccctcccccg    360

gttttcatct agatttgggt tttctcgctt ggcctctccc gcaaccggag tgtgaaaggc    420

agtggaggga ggaccttgtc tcctgttgcc tttaaccctc tcccgcccgc cgcccttggc    480

cctggtcctc gctgtctctc catccctcgt gtccttcctt tctccttgca gcgctcctac    540

ttcaccgtcc tcctctgtct gccgctcctc aggcggatgc ccccttttta gtaccccttt    600

ccccacgcgg ttccctttcc ggtttcatag agagaccggg tgggagggag gaggggacaa    660

tgaaaacagt aataaatgaa tgaacccga                                      689


<210>  2571
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  2571

Met Asp Ala Gly Lys Leu Gly Asp Val Cys Ala Thr Gly Lys Ala Gly 
1               5                   10                  15


Glu Met Pro Gln Ser Arg Ser Pro Thr Cys Ala Pro Leu Pro Ser Pro 
            20                  25                  30


Gly Phe His Leu Asp Leu Gly Phe Leu Ala Trp Pro Leu Pro Gln Pro 
        35                  40                  45


Glu Cys Glu Arg Gln Trp Arg Glu Asp Leu Val Ser Cys Cys Leu 
    50                  55                  60


<210>  2572
<211>  267
<212>  DNA
<213>  Homo sapiens

<400>  2572
atgggcacca gggatatagc cgagactgac cccaagaatg agcaggaact cacctcagtg     60

gtgcagaaac tcctgcagca gatccaagat aaatttcaga ccatgtctga ccagatcatt    120

gggagaactg atgatatgag tagttgcact gatgatctgg aaaagaacat cgcagatctc    180

atgacacagg ctggggtgga agaactggaa agtaaaaaca agatacctgc cacacaagag    240

gtgaaggttg ctaataattt atactga                                        267


<210>  2573
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  2573

Met Gly Thr Arg Asp Ile Ala Glu Thr Asp Pro Lys Asn Glu Gln Glu 
1               5                   10                  15


Leu Thr Ser Val Val Gln Lys Leu Leu Gln Gln Ile Gln Asp Lys Phe 
            20                  25                  30


Gln Thr Met Ser Asp Gln Ile Ile Gly Arg Thr Asp Asp Met Ser Ser 
        35                  40                  45


Cys Thr Asp Asp Leu Glu Lys Asn Ile Ala Asp Leu Met Thr Gln Ala 
    50                  55                  60


Gly Val Glu Glu Leu Glu Ser Lys Asn Lys Ile Pro Ala Thr Gln Glu 
65                  70                  75                  80


Val Lys Val Ala Asn Asn Leu Tyr 
                85


<210>  2574
<211>  300
<212>  DNA
<213>  Homo sapiens

<400>  2574
atgctgcagc cgctcaaaga gcagcagtgc gtcatccctg gtgtatctga agacagcaac     60

aatcacaacc tgatgttgga ggctaccaag tggtccacca tccaggggct ggtggaattc    120

ctgcagctct gcaagcaagt ggccaagata ctgtctgcct tgaagtatcc caccatcagc    180

acagtgaaac tgctgtttca catgctgcta aataccacgt tcaacaacaa ggagactgac    240

tccaaggaga tccccatggc caagagggtg attgccaagg agctctacaa gacctgctag    300


<210>  2575
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  2575

Met Leu Gln Pro Leu Lys Glu Gln Gln Cys Val Ile Pro Gly Val Ser 
1               5                   10                  15


Glu Asp Ser Asn Asn His Asn Leu Met Leu Glu Ala Thr Lys Trp Ser 
            20                  25                  30


Thr Ile Gln Gly Leu Val Glu Phe Leu Gln Leu Cys Lys Gln Val Ala 
        35                  40                  45


Lys Ile Leu Ser Ala Leu Lys Tyr Pro Thr Ile Ser Thr Val Lys Leu 
    50                  55                  60


Leu Phe His Met Leu Leu Asn Thr Thr Phe Asn Asn Lys Glu Thr Asp 
65                  70                  75                  80


Ser Lys Glu Ile Pro Met Ala Lys Arg Val Ile Ala Lys Glu Leu Tyr 
                85                  90                  95


Lys Thr Cys 



<210>  2576
<211>  378
<212>  DNA
<213>  Homo sapiens

<400>  2576
atgggcatgt ttccaaatgt caccatcttc ctggacccac gctacaagag gctgcccttc     60

ctgcttgtct tcgagaggca gcagatggag aactctgtgg tcaggggcca aggcctcctg    120

gacaacgtca aagacggcag ctaccggctg gccaatgcaa gatctaccct ttgccggaaa    180

aacgtccccc aaatggtcaa caccaagagg aaccggctgg cccctaacaa gcaggtcttt    240

ctgtacctga acgagcttaa ccaggcagag gcggaggcag agcccgaggc ccaggacaaa    300

aagcagtggg gcttggatag agagcaggtg ttcccttggg aaacggtgtc agccaagctt    360

ctttggcatc tgggatag                                                  378


<210>  2577
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  2577

Met Gly Met Phe Pro Asn Val Thr Ile Phe Leu Asp Pro Arg Tyr Lys 
1               5                   10                  15


Arg Leu Pro Phe Leu Leu Val Phe Glu Arg Gln Gln Met Glu Asn Ser 
            20                  25                  30


Val Val Arg Gly Gln Gly Leu Leu Asp Asn Val Lys Asp Gly Ser Tyr 
        35                  40                  45


Arg Leu Ala Asn Ala Arg Ser Thr Leu Cys Arg Lys Asn Val Pro Gln 
    50                  55                  60


Met Val Asn Thr Lys Arg Asn Arg Leu Ala Pro Asn Lys Gln Val Phe 
65                  70                  75                  80


Leu Tyr Leu Asn Glu Leu Asn Gln Ala Glu Ala Glu Ala Glu Pro Glu 
                85                  90                  95


Ala Gln Asp Lys Lys Gln Trp Gly Leu Asp Arg Glu Gln Val Phe Pro 
            100                 105                 110


Trp Glu Thr Val Ser Ala Lys Leu Leu Trp His Leu Gly 
        115                 120                 125


<210>  2578
<211>  1962
<212>  DNA
<213>  Homo sapiens

<400>  2578
cttggaattc tccctctcag gaaactaaca gcctgctatg aagcccaagc cacaaagaga     60

ggccaagggg aaataaacag agtgtgatta tatgcaaaac ctacaagaat gaggacctcc    120

aaactcagtg tacagagtga ttttctgctg aaacaattgg cttttaaaaa attgtgtgac    180

tgaccagcag cagtggctca catctgtaat cccagcactt tgggaggccg agaaaataaa    240

agagacatca gtgtgtgaat gacgactttc tgttgctgac ttggaagaca gaggaattgg    300

gtcatgagcc gaggaaggtg ggcagcttct aaaaggcgga aaagaactga attgaattca    360

aatcaaaaaa ggtctgaacc tcatttaaaa gatggttttg taactgaaga attgaaagga    420

tttctttatg aactagcatc atcttaagac aaaggataag gaccctgaag acagcattat    480

agtgaatccc agaggtgctc tccaaaatgg tgctaataca gccaagaata caggtatgag    540

gaaggatgtg gaagggtacc ttacaggaga aagcaccact tatccaccaa gatggcagag    600

gccttctttt ctgacccgtg gtacaaaaag aaaacattat aaggagagac aataggcaaa    660

aaagagcaca cgagaagaaa catagaatga aagaaaagag agggtcaaag agaagaaaaa    720

taagatcaca tgaaggtgat aatacaattt tatatagaac acggcaattt gcaatccaca    780

agctgatcta atatttaatg tttaagaaat ccaggctgtg taaataaatt ttggaaatga    840

gaactctcca agagcagact caaggtgatc tgggctggat cttactcctt ccatgtctca    900

ggtggcccca ggaggacaac attgtcaaat aaagtttagc ctaaagctga ctccttactt    960

attttaagtt cagcctaaag atttatctgt acatcatgaa ctatagccta aacggaagta   1020

taaacaggct acaatctact cttgtgccaa tcactgagtt ttggccaatc gattgcggtc   1080

aacagttcaa atcatgtttg aataagacaa atgccgagct gttaccaatc tggctgtttc   1140

tgtacctcac ttctgttttg tgtatgtcac tttatttttt ctgtccataa atcctcttcc   1200

accacgcagc tgcgctgcag tctctgagcc tactctggct ctggaggcgg cccgataggc   1260

gaattgttct ttgctcaatt aaattcttaa atgtaatacg gctgaagttt ttcctttaac   1320

agtatacaac tgtgaagtgg ttttatcagg catcataggt ggagaaatag tagaccagaa   1380

gtgcaagagg catatgcaac accattccct gctgtaccag tattatccag tgacacctta   1440

tctggttatt aaccaaagct gctttggcat aattccagtg gctgaagtga gaggaagcga   1500

ggatatggct gacattctcc aagaagcagt gacttcagaa gatgactggc atcttgaact   1560

tcaggaaaat gcttggcctt tttaactctg aaagtctgtt tgaaactcag aagaagaaaa   1620

ttaggtgaat acaaaactgc tgccaaactt agaaacttgg ttaaatatcc tgcagaaaat   1680

atcatgggct tttcagagtc cagttaaata tctacagatt atatttccag tttcatacct   1740

ggggcattaa ctctattcat tttactagct ttagtgaatt ttacttctgg agcataacat   1800

tgcattgaaa atgtgtcctc taacctatga tatttatgta tcgtttaata tgaaatttat   1860

gaggttccat ttctgatttc caaatggatg caaattagaa cacaggatat ttacattctt   1920

tcatttctaa cccacataca taaagtttga ctttaaaatg cc                      1962


<210>  2579
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  2579

Met Ser Arg Gly Arg Trp Ala Ala Ser Lys Arg Arg Lys Arg Thr Glu 
1               5                   10                  15


Leu Asn Ser Asn Gln Lys Arg Ser Glu Pro His Leu Lys Asp Gly Phe 
            20                  25                  30


Val Thr Glu Glu Leu Lys Gly Phe Leu Tyr Glu Leu Ala Ser Ser 
        35                  40                  45


<210>  2580
<211>  653
<212>  DNA
<213>  Homo sapiens

<400>  2580
gctcttggaa ttctccctct caggaaacta acagcctgct atgaagccca agccacaaag     60

agaggccaag gggaaataaa cagagtgtga ttatatgcaa aacctacaag aatgaggacc    120

tccaaactca gtgtacagag tgattttctg ctgaaacaat tggttggtgt aagaatattg    180

gaagcctgaa cctagcactg tctgctactg gcctgacgtc ttttccacaa catgggaaga    240

gattgcctgg gaaggaagcc aactctgtgg aaagcataag aaataaccaa agaaagatgg    300

cacatcttat ctggacagtg ttgaagtgaa cttttaaaat gaagtaaatt ttgttgaatc    360

gtagcctgag acaatgaagg ggtaatttag gggaagaacc cctacctcta agttgccttt    420

tttgaccaca tgctggaagc tgggtgtcgg ttacaagctg actgtaaaaa acggcaggaa    480

ggagaggggc ttcttctcag ccttaccttt aggaaatcaa aaaaaaacca aaactgaatc    540

ctcacttagc ggaggggaac aaagaactca gattctaagg acaaggcaga atccattagg    600

tatagggcag aagctaaaaa aaaggagagg actctgatta aaacataaaa ccc           653


<210>  2581
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  2581

Met Leu Glu Ala Gly Cys Arg Leu Gln Ala Asp Cys Lys Lys Arg Gln 
1               5                   10                  15


Glu Gly Glu Gly Leu Leu Leu Ser Leu Thr Phe Arg Lys Ser Lys Lys 
            20                  25                  30


Asn Gln Asn 
        35


<210>  2582
<211>  617
<212>  DNA
<213>  Homo sapiens

<400>  2582
gctatcattg ccaactgtat tcagcggatc caatgaagaa ttctgcatcc agccctagag     60

atgttggaga cacaagctgc agatgtccag taatttcctg gatagaaatt ttattatctg    120

caaagaatga tatcacatca caaggatgtc caggtaatcc agttccctgt gcactatatt    180

actacacatg ccaaaagagt taacactacc cttgagcaag aaggtgtagc actaggagcc    240

tggtgaagcc aaacaagggt gaaggcctgg ccagaatgtg accaaaggct ctattcctag    300

cttcggtaac acatgaaaaa ggacattgag ttcttccttc actgcagtcc tgcctcaagt    360

gagctgtgcc tgtaccctgg aaatggaaac attagctctt cctttcctca acacctactt    420

cctcagcatt ctgcaaagcc ttcagctgga gtgaagtctt ccatgacaca agatttttct    480

aaatcacttc ctgattgaaa acattgctta cattgcccca ggatacccat tcttgaccat    540

gaggtattat atttgaatat acactgatgg atttagtttg ataacatttt tattacagat    600

tttacattct tgtttgt                                                   617


<210>  2583
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  2583

Met Lys Asn Ser Ala Ser Ser Pro Arg Asp Val Gly Asp Thr Ser Cys 
1               5                   10                  15


Arg Cys Pro Val Ile Ser Trp Ile Glu Ile Leu Leu Ser Ala Lys Asn 
            20                  25                  30


Asp Ile Thr Ser Gln Gly Cys Pro Gly Asn Pro Val Pro Cys Ala Leu 
        35                  40                  45


Tyr Tyr Tyr Thr Cys Gln Lys Ser 
    50                  55


<210>  2584
<211>  5404
<212>  DNA
<213>  Homo sapiens

<400>  2584
aaaagggcca gccctccagc tggcccactc cccctccggg ctttcgcccg ccctctctcc     60

ctcccttttt tgcccgccct ggccctgccc ctgcccctgc cccctcctct cagcccctcc    120

gcgcccgggg tgtcattggg cccgggagac gggagccaac ttcaggctgc tcagaggaag    180

cccgtgcagt cagtcacctg ggtgcaagag cgttgctgcc tcgggctctc ccgctgcagg    240

gagagcggca ctcgctggcc tggatgtggt tggatttagg ggggctccgc agcaggggtt    300

tcgtggcggt ggcaagcgct gcaacaggta gacggcgaga gacggacccc ggccgaggca    360

gcgatggaga ccaaaggcta ccacagtctc cctgaaggtc tagatatgga aagacggtgg    420

ggtcaagttt ctcaggctgt ggagcgttct tccctgggac ctacagagag gaccgatgag    480

aataactaca tggagattgt caacgtaagc tgtgtttccg gtgctattcc aaacaacagt    540

actcaaggaa gcagcaaaga aaaacaagaa ctactccctt gccttcagca agacaataat    600

cggcctggga ttttaacatc tgatattaaa actgagctgg aatctaagga actttcagca    660

actgtagctg agtccatggg tttatatatg gattctgtaa gagatgctga ctattcctat    720

gagcagcaga accaacaagg aagcatgagt ccagctaaga tttatcagaa tgttgaacag    780

ctggtgaaat tttacaaagg aaatggccat cgtccttcca ctctaagttg tgtgaacacg    840

cccttgagat catttatgtc tgactctggg agctccgtga atggtggcgt catgcgcgcc    900

gttgttaaaa gccctatcat gtgtcatgag aaaagcccgt ctgtttgcag ccctctgaac    960

atgacatctt cggtttgcag ccctgctgga atcaactctg tgtcctccac cacagccagc   1020

tttggcagtt ttccagtgca cagcccaatc acccagggaa ctcctctgac atgctcccct   1080

aatgttgaaa atcgaggctc caggtcgcac agccctgcac atgctagcaa tgtgggctct   1140

cctctctcaa gtccgttaag tagcatgaaa tcctcaattt ccagccctcc aagtcactgc   1200

agtgtaaaat ctccagtctc cagtcccaat aatgtcactc tgagatcctc tgtgtctagc   1260

cctgcaaata ttaacaactc aaggtgctct gtttccagcc cttcgaacac taataacaga   1320

tccacgcttt ccagtccggc agccagtact gtgggatcta tctgtagccc tgtaaacaat   1380

gccttcagct acactgcttc tggcacctct gctggatcca gtacattgcg ggatgtggtt   1440

cccagtccag acacgcagga gaaaggtgct caagaggtcc cttttcctaa gactgaggaa   1500

gtagagagtg ccatctcaaa tggtgtgact ggccagctta atattgtcca gtacataaaa   1560

ccagaaccag atggagcttt tagcagctca tgtctaggag gaaatagcaa aataaattcg   1620

gattcttcat tctcagtacc aataaagcaa gaatcaacca agcattcatg ttcaggcacc   1680

tcttttaaag ggaatccaac agtaaacccg tttccattta tggatggctc gtatttttcc   1740

tttatggatg ataaagacta ttattcccta tcaggaattt taggaccacc tgtgcccggc   1800

tttgatggta actgtgaagg cagcggattc ccagtgggta ttaaacaaga accagatgat   1860

gggagctatt acccagaggc cagcatccct tcctctgcta ttgttggggt gaattcaggt   1920

ggacagtcct tccactacag gattggtgct caaggtacaa tatctttatc acgatcggct   1980

agagaccaat ctttccaaca cctgagttcc tttcctcctg tcaatacttt agtggagtca   2040

tggaaatcac acggcgacct gtcgtctaga agaagtgatg ggtatccggt cttagaatac   2100

attccagaaa atgtatcaag ctctacttta cgaagtgttt ctactggatc ttcaagacct   2160

tcaaaaatat gtttggtgtg tggggatgag gcttcaggat gccattatgg ggtagtcacc   2220

tgtggcagct gcaaagtttt cttcaaaaga gcagtggaag ggcaacacaa ctatttatgt   2280

gctggaagaa atgattgcat cattgataag attcgacgaa agaattgtcc tgcttgcaga   2340

cttcagaaat gtcttcaagc tggaatgaat ttaggagaga gaagatgcat cagtctgcca   2400

tgtatgaact atgccagggg atgcaccaaa tcagccttca gttcgttcga ctgcagctca   2460

cctttgaaga atacaccatc atgaaagttt tgctgctact aagcacaatt ccaaaggatg   2520

gcctcaaaag ccaggctgca tttgaagaaa tgaggacaaa ttacatcaaa gaactgagga   2580

agatggtaac taagtgtccc aacaattctg ggcagagctg gcagaggttc taccaactga   2640

ccaagctgct ggactccatg catgacctgg tgagcgacct gctggaattc tgcttctaca   2700

ccttccgaga gtcccatgcg ctgaaggtag agttccccgc aatgctggtg gagatcatca   2760

gcgaccagct gcccaaggtg gagtcgggga acgccaagcc gctctacttc caccggaagt   2820

gactgcccgc tgcccagaag aactttgcct taagtttccc tgtgttgttc cacacccaga   2880

aggacccaag aaaacctgtt tttaacatgt gatggttgat tcacacttgt tcaacagttt   2940

ctcaagttta aagtcatgtc agaggtttgg agccgggaaa gctgtttttc cgtggatttg   3000

gcgagaccag agcagtctga aggattcccc acctccaatc ccccagcgct tagaaacatg   3060

ttcctgttcc tcgggatgaa aagccatatc tagtcaataa ctctgatttt gatattttca   3120

cagatggaag aagttttaac tatgccgtgt agtttctggt atcgttcgct tgttttaaaa   3180

gggttcaagg actaacgaac gttttaaagc ttacccttgg tttgcacata aaacgtatag   3240

tcaatatggg gcattaatat tcttttgtta ttaaaaaaac acaaaaaaat aataaaaaaa   3300

tatatacaga ttcctgttgt gtaataacag aactcgtggc gtggggcagc agctgcctct   3360

gagccctcgc tcgtccacgg tcttctgcat cactggtata cacactcgtt agcgtccatt   3420

tcttatttaa ttagaatgga taagatgatg ttaaatgcct tggtttgatt tctagtatct   3480

attgtgttgg ctttacaaat aattttttgc agtcttttgc tgtgctgtac attactgtat   3540

gtataaatta tgaaggacct gaaataaggt ataaggatct tttgtaaatg agacacatac   3600

aaaaaaaatc tttaatggtt aataggatga atgggaaagt atttttgaaa gaattctatt   3660

ttgctggaga ctatttaagt actatctttg tctaaacaag gtaatttttt tttgtaaagt   3720

gcaatgtcct gcatgcataa tgaaccgttt acagtgtatt taagaaaggg aaagctgtgc   3780

cttttttagc ttcatatcta atttaccatt attttacagt ctctgttgta aataaccaca   3840

ctgaaacctc ttcggttgtc ttgaaacctt tctacttttt ctgtactttt tgttttgttc   3900

ttggtctccc gcttggggca tttgtgggac tccagcacgt tttctggctt ctgcttcatc   3960

ctgctccatc ggggaatgac acactgcggt gtctgcagct cctggaaggt gtcatttgac   4020

aacacatgtg ggagaggagg tccttggagt gctgcagctt tgggaaagct gcctcgtttc   4080

ccttttcctc tagaagcaga accagctcta cgagagtgag actgggaact tgatggctca   4140

gagagcatct tttcctccca ttttagaaaa tcagattttc tcctgtggga aaaaaaaatt   4200

ccatgcactc tctctctgtt aaagatcagc tattcccttc tgatcttgga aagaggttct   4260

gcactcctgg aaccggtcac aggaacgcac agatcatggc aggatgcgct gggacggccc   4320

atcttggcaa ggttcagtct gaatggcatg gagaccggga gatagagggg ttttagattt   4380

ttaaaaggta ggttttaaaa ataagtttta tacataaaca gttttggaga aaaattacag   4440

atcatataag caagacagtg gcactaaaat gtttaattca ttaatctgtt tgtttggcac   4500

tgatgcaatg tatggctttt ctcttgcccc aaatcacaaa catatgtatc tttggggaaa   4560

ctaacaatat gattgcacta aataaactac tttgaataga ggccaaatta atcttttaaa   4620

aatgatgata atcatcaggt ttactcagtg aaatcatatt aattattttc caaaatctaa   4680

aagctgtagc tggagaagcc catggccacg aggaagcagc aattaattag atcaacactt   4740

ttctccaggg ttcaccatgc aggcaacatt accttgtctt tcaaaagaca cctgccttat   4800

gcaaggggaa acctgtgaaa gctgcactca gagggaggag tttttcttac ataatttgca   4860

atttcaggaa tttaatttat aggcagatct ttaaatacag tcaacttacg gtgcacagta   4920

atatgaaagc cacactttga aggtaataaa tacacagcat gcagactggg agttgctagc   4980

aaacaaatgg cttacttaca aaagcagctt ttagttcaga cttagttttt ataaaatggg   5040

aattctgact tacttaacca ggtttgggat ggagatggtc tgcatcagct ttttgtatta   5100

acaaagttac tggctctttg tgtgtctcca ggtaactttg cttgattaaa cagcaaagcc   5160

atattctaaa ttcactgttg aatgcctgtc ccagtccaaa ttgtctgtct gctcttattt   5220

ttgtaccata ttgctcttaa aaatcttggt ttggtacagt tcataattca ccaaaagttc   5280

atataattta aagaaacact aaattagttt aaaatgaagc aatttatatc tttatgcaaa   5340

aacatatgtc tgtctttgca aaggactgta agcagattac aataaatcct ttactttaat   5400

cacc                                                                5404


<210>  2585
<211>  706
<212>  PRT
<213>  Homo sapiens

<400>  2585

Met Glu Thr Lys Gly Tyr His Ser Leu Pro Glu Gly Leu Asp Met Glu 
1               5                   10                  15


Arg Arg Trp Gly Gln Val Ser Gln Ala Val Glu Arg Ser Ser Leu Gly 
            20                  25                  30


Pro Thr Glu Arg Thr Asp Glu Asn Asn Tyr Met Glu Ile Val Asn Val 
        35                  40                  45


Ser Cys Val Ser Gly Ala Ile Pro Asn Asn Ser Thr Gln Gly Ser Ser 
    50                  55                  60


Lys Glu Lys Gln Glu Leu Leu Pro Cys Leu Gln Gln Asp Asn Asn Arg 
65                  70                  75                  80


Pro Gly Ile Leu Thr Ser Asp Ile Lys Thr Glu Leu Glu Ser Lys Glu 
                85                  90                  95


Leu Ser Ala Thr Val Ala Glu Ser Met Gly Leu Tyr Met Asp Ser Val 
            100                 105                 110


Arg Asp Ala Asp Tyr Ser Tyr Glu Gln Gln Asn Gln Gln Gly Ser Met 
        115                 120                 125


Ser Pro Ala Lys Ile Tyr Gln Asn Val Glu Gln Leu Val Lys Phe Tyr 
    130                 135                 140


Lys Gly Asn Gly His Arg Pro Ser Thr Leu Ser Cys Val Asn Thr Pro 
145                 150                 155                 160


Leu Arg Ser Phe Met Ser Asp Ser Gly Ser Ser Val Asn Gly Gly Val 
                165                 170                 175


Met Arg Ala Val Val Lys Ser Pro Ile Met Cys His Glu Lys Ser Pro 
            180                 185                 190


Ser Val Cys Ser Pro Leu Asn Met Thr Ser Ser Val Cys Ser Pro Ala 
        195                 200                 205


Gly Ile Asn Ser Val Ser Ser Thr Thr Ala Ser Phe Gly Ser Phe Pro 
    210                 215                 220


Val His Ser Pro Ile Thr Gln Gly Thr Pro Leu Thr Cys Ser Pro Asn 
225                 230                 235                 240


Val Glu Asn Arg Gly Ser Arg Ser His Ser Pro Ala His Ala Ser Asn 
                245                 250                 255


Val Gly Ser Pro Leu Ser Ser Pro Leu Ser Ser Met Lys Ser Ser Ile 
            260                 265                 270


Ser Ser Pro Pro Ser His Cys Ser Val Lys Ser Pro Val Ser Ser Pro 
        275                 280                 285


Asn Asn Val Thr Leu Arg Ser Ser Val Ser Ser Pro Ala Asn Ile Asn 
    290                 295                 300


Asn Ser Arg Cys Ser Val Ser Ser Pro Ser Asn Thr Asn Asn Arg Ser 
305                 310                 315                 320


Thr Leu Ser Ser Pro Ala Ala Ser Thr Val Gly Ser Ile Cys Ser Pro 
                325                 330                 335


Val Asn Asn Ala Phe Ser Tyr Thr Ala Ser Gly Thr Ser Ala Gly Ser 
            340                 345                 350


Ser Thr Leu Arg Asp Val Val Pro Ser Pro Asp Thr Gln Glu Lys Gly 
        355                 360                 365


Ala Gln Glu Val Pro Phe Pro Lys Thr Glu Glu Val Glu Ser Ala Ile 
    370                 375                 380


Ser Asn Gly Val Thr Gly Gln Leu Asn Ile Val Gln Tyr Ile Lys Pro 
385                 390                 395                 400


Glu Pro Asp Gly Ala Phe Ser Ser Ser Cys Leu Gly Gly Asn Ser Lys 
                405                 410                 415


Ile Asn Ser Asp Ser Ser Phe Ser Val Pro Ile Lys Gln Glu Ser Thr 
            420                 425                 430


Lys His Ser Cys Ser Gly Thr Ser Phe Lys Gly Asn Pro Thr Val Asn 
        435                 440                 445


Pro Phe Pro Phe Met Asp Gly Ser Tyr Phe Ser Phe Met Asp Asp Lys 
    450                 455                 460


Asp Tyr Tyr Ser Leu Ser Gly Ile Leu Gly Pro Pro Val Pro Gly Phe 
465                 470                 475                 480


Asp Gly Asn Cys Glu Gly Ser Gly Phe Pro Val Gly Ile Lys Gln Glu 
                485                 490                 495


Pro Asp Asp Gly Ser Tyr Tyr Pro Glu Ala Ser Ile Pro Ser Ser Ala 
            500                 505                 510


Ile Val Gly Val Asn Ser Gly Gly Gln Ser Phe His Tyr Arg Ile Gly 
        515                 520                 525


Ala Gln Gly Thr Ile Ser Leu Ser Arg Ser Ala Arg Asp Gln Ser Phe 
    530                 535                 540


Gln His Leu Ser Ser Phe Pro Pro Val Asn Thr Leu Val Glu Ser Trp 
545                 550                 555                 560


Lys Ser His Gly Asp Leu Ser Ser Arg Arg Ser Asp Gly Tyr Pro Val 
                565                 570                 575


Leu Glu Tyr Ile Pro Glu Asn Val Ser Ser Ser Thr Leu Arg Ser Val 
            580                 585                 590


Ser Thr Gly Ser Ser Arg Pro Ser Lys Ile Cys Leu Val Cys Gly Asp 
        595                 600                 605


Glu Ala Ser Gly Cys His Tyr Gly Val Val Thr Cys Gly Ser Cys Lys 
    610                 615                 620


Val Phe Phe Lys Arg Ala Val Glu Gly Gln His Asn Tyr Leu Cys Ala 
625                 630                 635                 640


Gly Arg Asn Asp Cys Ile Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro 
                645                 650                 655


Ala Cys Arg Leu Gln Lys Cys Leu Gln Ala Gly Met Asn Leu Gly Glu 
            660                 665                 670


Arg Arg Cys Ile Ser Leu Pro Cys Met Asn Tyr Ala Arg Gly Cys Thr 
        675                 680                 685


Lys Ser Ala Phe Ser Ser Phe Asp Cys Ser Ser Pro Leu Lys Asn Thr 
    690                 695                 700


Pro Ser 
705


<210>  2586
<211>  5549
<212>  DNA
<213>  Homo sapiens

<400>  2586
aaaagggcca gccctccagc tggcccactc cccctccggg ctttcgcccg ccctctctcc     60

ctcccttttt tgcccgccct ggccctgccc ctgcccctgc cccctcctct cagcccctcc    120

gcgcccgggg tgtcattggg cccgggagac gggagccaac ttcaggctgc tcagaggaag    180

cccgtgcagt cagtcacctg ggtgcaagag cgttgctgcc tcgggctctc ccgctgcagg    240

gagagcggca ctcgctggcc tggatgtggt tggatttagg ggggctccgc agcaggggtt    300

tcgtggcggt ggcaagcgct gcaacaggta gacggcgaga gacggacccc ggccgaggca    360

gcgatggaga ccaaaggcta ccacagtctc cctgaaggtc tagatatgga aagacggtgg    420

ggtcaagttt ctcaggctgt ggagcgttct tccctgggac ctacagagag gaccgatgag    480

aataactaca tggagattgt caacgtaagc tgtgtttccg gtgctattcc aaacaacagt    540

actcaaggaa gcagcaaaga aaaacaagaa ctactccctt gccttcagca agacaataat    600

cggcctggga ttttaacatc tgatattaaa actgagctgg aatctaagga actttcagca    660

actgtagctg agtccatggg tttatatatg gattctgtaa gagatgctga ctattcctat    720

gagcagcaga accaacaagg aagcatgagt ccagctaaga tttatcagaa tgttgaacag    780

ctggtgaaat tttacaaagg aaatggccat cgtccttcca ctctaagttg tgtgaacacg    840

cccttgagat catttatgtc tgactctggg agctccgtga atggtggcgt catgcgcgcc    900

gttgttaaaa gccctatcat gtgtcatgag aaaagcccgt ctgtttgcag ccctctgaac    960

atgacatctt cggtttgcag ccctgctgga atcaactctg tgtcctccac cacagccagc   1020

tttggcagtt ttccagtgca cagcccaatc acccagggaa ctcctctgac atgctcccct   1080

aatgttgaaa atcgaggctc caggtcgcac agccctgcac atgctagcaa tgtgggctct   1140

cctctctcaa gtccgttaag tagcatgaaa tcctcaattt ccagccctcc aagtcactgc   1200

agtgtaaaat ctccagtctc cagtcccaat aatgtcactc tgagatcctc tgtgtctagc   1260

cctgcaaata ttaacaactc aaggtgctct gtttccagcc cttcgaacac taataacaga   1320

tccacgcttt ccagtccggc agccagtact gtgggatcta tctgtagccc tgtaaacaat   1380

gccttcagct acactgcttc tggcacctct gctggatcca gtacattgcg ggatgtggtt   1440

cccagtccag acacgcagga gaaaggtgct caagaggtcc cttttcctaa gactgaggaa   1500

gtagagagtg ccatctcaaa tggtgtgact ggccagctta atattgtcca gtacataaaa   1560

ccagaaccag atggagcttt tagcagctca tgtctaggag gaaatagcaa aataaattcg   1620

gattcttcat tctcagtacc aataaagcaa gaatcaacca agcattcatg ttcaggcacc   1680

tcttttaaag ggaatccaac agtaaacccg tttccattta tggatggctc gtatttttcc   1740

tttatggatg ataaagacta ttattcccta tcaggaattt taggaccacc tgtgcccggc   1800

tttgatggta actgtgaagg cagcggattc ccagtgggta ttaaacaaga accagatgat   1860

gggagctatt acccagaggc cagcatccct tcctctgcta ttgttggggt gaattcaggt   1920

ggacagtcct tccactacag gattggtgct caaggtacaa tatctttatc acgatcggct   1980

agagaccaat ctttccaaca cctgagttcc tttcctcctg tcaatacttt agtggagtca   2040

tggaaatcac acggcgacct gtcgtctaga agaagtgatg ggtatccggt cttagaatac   2100

attccagaaa atgtatcaag ctctacttta cgaagtgttt ctactggatc ttcaagacct   2160

tcaaaaatat gtttggtgtg tggggatgag gcttcaggat gccattatgg ggtagtcacc   2220

tgtggcagct gcaaagtttt cttcaaaaga gcagtggaag ggcaacacaa ctatttatgt   2280

gctggaagaa atgattgcat cattgataag attcgacgaa agaattgtcc tgcttgcaga   2340

cttcagaaat gtcttcaagc tggaatgaat ttaggaggat ttaaaaactt gcctcttgag   2400

gaccaaatta ccctaatcca gtattcttgg atgtgtctat catcatttgc cttgagctgg   2460

agatcgtaca aacatacgaa cagccaattt ctctattttg caccagacct agtctttaat   2520

gaagagaaga tgcatcagtc tgccatgtat gaactatgcc aggggatgca ccaaatcagc   2580

cttcagttcg ttcgactgca gctcaccttt gaagaataca ccatcatgaa agttttgctg   2640

ctactaagca caattccaaa ggatggcctc aaaagccagg ctgcatttga agaaatgagg   2700

acaaattaca tcaaagaact gaggaagatg gtaactaagt gtcccaacaa ttctgggcag   2760

agctggcaga ggttctacca actgaccaag ctgctggact ccatgcatga cctggtgagc   2820

gacctgctgg aattctgctt ctacaccttc cgagagtccc atgcgctgaa ggtagagttc   2880

cccgcaatgc tggtggagat catcagcgac cagctgccca aggtggagtc ggggaacgcc   2940

aagccgctct acttccaccg gaagtgactg cccgctgccc agaagaactt tgccttaagt   3000

ttccctgtgt tgttccacac ccagaaggac ccaagaaaac ctgtttttaa catgtgatgg   3060

ttgattcaca cttgttcaac agtttctcaa gtttaaagtc atgtcagagg tttggagccg   3120

ggaaagctgt ttttccgtgg atttggcgag accagagcag tctgaaggat tccccacctc   3180

caatccccca gcgcttagaa acatgttcct gttcctcggg atgaaaagcc atatctagtc   3240

aataactctg attttgatat tttcacagat ggaagaagtt ttaactatgc cgtgtagttt   3300

ctggtatcgt tcgcttgttt taaaagggtt caaggactaa cgaacgtttt aaagcttacc   3360

cttggtttgc acataaaacg tatagtcaat atggggcatt aatattcttt tgttattaaa   3420

aaaacacaaa aaaataataa aaaaatatat acagattcct gttgtgtaat aacagaactc   3480

gtggcgtggg gcagcagctg cctctgagcc ctcgctcgtc cacggtcttc tgcatcactg   3540

gtatacacac tcgttagcgt ccatttctta tttaattaga atggataaga tgatgttaaa   3600

tgccttggtt tgatttctag tatctattgt gttggcttta caaataattt tttgcagtct   3660

tttgctgtgc tgtacattac tgtatgtata aattatgaag gacctgaaat aaggtataag   3720

gatcttttgt aaatgagaca catacaaaaa aaatctttaa tggttaatag gatgaatggg   3780

aaagtatttt tgaaagaatt ctattttgct ggagactatt taagtactat ctttgtctaa   3840

acaaggtaat ttttttttgt aaagtgcaat gtcctgcatg cataatgaac cgtttacagt   3900

gtatttaaga aagggaaagc tgtgcctttt ttagcttcat atctaattta ccattatttt   3960

acagtctctg ttgtaaataa ccacactgaa acctcttcgg ttgtcttgaa acctttctac   4020

tttttctgta ctttttgttt tgttcttggt ctcccgcttg gggcatttgt gggactccag   4080

cacgttttct ggcttctgct tcatcctgct ccatcgggga atgacacact gcggtgtctg   4140

cagctcctgg aaggtgtcat ttgacaacac atgtgggaga ggaggtcctt ggagtgctgc   4200

agctttggga aagctgcctc gtttcccttt tcctctagaa gcagaaccag ctctacgaga   4260

gtgagactgg gaacttgatg gctcagagag catcttttcc tcccatttta gaaaatcaga   4320

ttttctcctg tgggaaaaaa aaattccatg cactctctct ctgttaaaga tcagctattc   4380

ccttctgatc ttggaaagag gttctgcact cctggaaccg gtcacaggaa cgcacagatc   4440

atggcaggat gcgctgggac ggcccatctt ggcaaggttc agtctgaatg gcatggagac   4500

cgggagatag aggggtttta gatttttaaa aggtaggttt taaaaataag ttttatacat   4560

aaacagtttt ggagaaaaat tacagatcat ataagcaaga cagtggcact aaaatgttta   4620

attcattaat ctgtttgttt ggcactgatg caatgtatgg cttttctctt gccccaaatc   4680

acaaacatat gtatctttgg ggaaactaac aatatgattg cactaaataa actactttga   4740

atagaggcca aattaatctt ttaaaaatga tgataatcat caggtttact cagtgaaatc   4800

atattaatta ttttccaaaa tctaaaagct gtagctggag aagcccatgg ccacgaggaa   4860

gcagcaatta attagatcaa cacttttctc cagggttcac catgcaggca acattacctt   4920

gtctttcaaa agacacctgc cttatgcaag gggaaacctg tgaaagctgc actcagaggg   4980

aggagttttt cttacataat ttgcaatttc aggaatttaa tttataggca gatctttaaa   5040

tacagtcaac ttacggtgca cagtaatatg aaagccacac tttgaaggta ataaatacac   5100

agcatgcaga ctgggagttg ctagcaaaca aatggcttac ttacaaaagc agcttttagt   5160

tcagacttag tttttataaa atgggaattc tgacttactt aaccaggttt gggatggaga   5220

tggtctgcat cagctttttg tattaacaaa gttactggct ctttgtgtgt ctccaggtaa   5280

ctttgcttga ttaaacagca aagccatatt ctaaattcac tgttgaatgc ctgtcccagt   5340

ccaaattgtc tgtctgctct tatttttgta ccatattgct cttaaaaatc ttggtttggt   5400

acagttcata attcaccaaa agttcatata atttaaagaa acactaaatt agtttaaaat   5460

gaagcaattt atatctttat gcaaaaacat atgtctgtct ttgcaaagga ctgtaagcag   5520

attacaataa atcctttact ttaatcacc                                     5549


<210>  2587
<211>  867
<212>  PRT
<213>  Homo sapiens

<400>  2587

Met Glu Thr Lys Gly Tyr His Ser Leu Pro Glu Gly Leu Asp Met Glu 
1               5                   10                  15


Arg Arg Trp Gly Gln Val Ser Gln Ala Val Glu Arg Ser Ser Leu Gly 
            20                  25                  30


Pro Thr Glu Arg Thr Asp Glu Asn Asn Tyr Met Glu Ile Val Asn Val 
        35                  40                  45


Ser Cys Val Ser Gly Ala Ile Pro Asn Asn Ser Thr Gln Gly Ser Ser 
    50                  55                  60


Lys Glu Lys Gln Glu Leu Leu Pro Cys Leu Gln Gln Asp Asn Asn Arg 
65                  70                  75                  80


Pro Gly Ile Leu Thr Ser Asp Ile Lys Thr Glu Leu Glu Ser Lys Glu 
                85                  90                  95


Leu Ser Ala Thr Val Ala Glu Ser Met Gly Leu Tyr Met Asp Ser Val 
            100                 105                 110


Arg Asp Ala Asp Tyr Ser Tyr Glu Gln Gln Asn Gln Gln Gly Ser Met 
        115                 120                 125


Ser Pro Ala Lys Ile Tyr Gln Asn Val Glu Gln Leu Val Lys Phe Tyr 
    130                 135                 140


Lys Gly Asn Gly His Arg Pro Ser Thr Leu Ser Cys Val Asn Thr Pro 
145                 150                 155                 160


Leu Arg Ser Phe Met Ser Asp Ser Gly Ser Ser Val Asn Gly Gly Val 
                165                 170                 175


Met Arg Ala Val Val Lys Ser Pro Ile Met Cys His Glu Lys Ser Pro 
            180                 185                 190


Ser Val Cys Ser Pro Leu Asn Met Thr Ser Ser Val Cys Ser Pro Ala 
        195                 200                 205


Gly Ile Asn Ser Val Ser Ser Thr Thr Ala Ser Phe Gly Ser Phe Pro 
    210                 215                 220


Val His Ser Pro Ile Thr Gln Gly Thr Pro Leu Thr Cys Ser Pro Asn 
225                 230                 235                 240


Val Glu Asn Arg Gly Ser Arg Ser His Ser Pro Ala His Ala Ser Asn 
                245                 250                 255


Val Gly Ser Pro Leu Ser Ser Pro Leu Ser Ser Met Lys Ser Ser Ile 
            260                 265                 270


Ser Ser Pro Pro Ser His Cys Ser Val Lys Ser Pro Val Ser Ser Pro 
        275                 280                 285


Asn Asn Val Thr Leu Arg Ser Ser Val Ser Ser Pro Ala Asn Ile Asn 
    290                 295                 300


Asn Ser Arg Cys Ser Val Ser Ser Pro Ser Asn Thr Asn Asn Arg Ser 
305                 310                 315                 320


Thr Leu Ser Ser Pro Ala Ala Ser Thr Val Gly Ser Ile Cys Ser Pro 
                325                 330                 335


Val Asn Asn Ala Phe Ser Tyr Thr Ala Ser Gly Thr Ser Ala Gly Ser 
            340                 345                 350


Ser Thr Leu Arg Asp Val Val Pro Ser Pro Asp Thr Gln Glu Lys Gly 
        355                 360                 365


Ala Gln Glu Val Pro Phe Pro Lys Thr Glu Glu Val Glu Ser Ala Ile 
    370                 375                 380


Ser Asn Gly Val Thr Gly Gln Leu Asn Ile Val Gln Tyr Ile Lys Pro 
385                 390                 395                 400


Glu Pro Asp Gly Ala Phe Ser Ser Ser Cys Leu Gly Gly Asn Ser Lys 
                405                 410                 415


Ile Asn Ser Asp Ser Ser Phe Ser Val Pro Ile Lys Gln Glu Ser Thr 
            420                 425                 430


Lys His Ser Cys Ser Gly Thr Ser Phe Lys Gly Asn Pro Thr Val Asn 
        435                 440                 445


Pro Phe Pro Phe Met Asp Gly Ser Tyr Phe Ser Phe Met Asp Asp Lys 
    450                 455                 460


Asp Tyr Tyr Ser Leu Ser Gly Ile Leu Gly Pro Pro Val Pro Gly Phe 
465                 470                 475                 480


Asp Gly Asn Cys Glu Gly Ser Gly Phe Pro Val Gly Ile Lys Gln Glu 
                485                 490                 495


Pro Asp Asp Gly Ser Tyr Tyr Pro Glu Ala Ser Ile Pro Ser Ser Ala 
            500                 505                 510


Ile Val Gly Val Asn Ser Gly Gly Gln Ser Phe His Tyr Arg Ile Gly 
        515                 520                 525


Ala Gln Gly Thr Ile Ser Leu Ser Arg Ser Ala Arg Asp Gln Ser Phe 
    530                 535                 540


Gln His Leu Ser Ser Phe Pro Pro Val Asn Thr Leu Val Glu Ser Trp 
545                 550                 555                 560


Lys Ser His Gly Asp Leu Ser Ser Arg Arg Ser Asp Gly Tyr Pro Val 
                565                 570                 575


Leu Glu Tyr Ile Pro Glu Asn Val Ser Ser Ser Thr Leu Arg Ser Val 
            580                 585                 590


Ser Thr Gly Ser Ser Arg Pro Ser Lys Ile Cys Leu Val Cys Gly Asp 
        595                 600                 605


Glu Ala Ser Gly Cys His Tyr Gly Val Val Thr Cys Gly Ser Cys Lys 
    610                 615                 620


Val Phe Phe Lys Arg Ala Val Glu Gly Gln His Asn Tyr Leu Cys Ala 
625                 630                 635                 640


Gly Arg Asn Asp Cys Ile Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro 
                645                 650                 655


Ala Cys Arg Leu Gln Lys Cys Leu Gln Ala Gly Met Asn Leu Gly Gly 
            660                 665                 670


Phe Lys Asn Leu Pro Leu Glu Asp Gln Ile Thr Leu Ile Gln Tyr Ser 
        675                 680                 685


Trp Met Cys Leu Ser Ser Phe Ala Leu Ser Trp Arg Ser Tyr Lys His 
    690                 695                 700


Thr Asn Ser Gln Phe Leu Tyr Phe Ala Pro Asp Leu Val Phe Asn Glu 
705                 710                 715                 720


Glu Lys Met His Gln Ser Ala Met Tyr Glu Leu Cys Gln Gly Met His 
                725                 730                 735


Gln Ile Ser Leu Gln Phe Val Arg Leu Gln Leu Thr Phe Glu Glu Tyr 
            740                 745                 750


Thr Ile Met Lys Val Leu Leu Leu Leu Ser Thr Ile Pro Lys Asp Gly 
        755                 760                 765


Leu Lys Ser Gln Ala Ala Phe Glu Glu Met Arg Thr Asn Tyr Ile Lys 
    770                 775                 780


Glu Leu Arg Lys Met Val Thr Lys Cys Pro Asn Asn Ser Gly Gln Ser 
785                 790                 795                 800


Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser Met His Asp 
                805                 810                 815


Leu Val Ser Asp Leu Leu Glu Phe Cys Phe Tyr Thr Phe Arg Glu Ser 
            820                 825                 830


His Ala Leu Lys Val Glu Phe Pro Ala Met Leu Val Glu Ile Ile Ser 
        835                 840                 845


Asp Gln Leu Pro Lys Val Glu Ser Gly Asn Ala Lys Pro Leu Tyr Phe 
    850                 855                 860


His Arg Lys 
865


<210>  2588
<211>  5900
<212>  DNA
<213>  Homo sapiens

<400>  2588
aaaagggcca gccctccagc tggcccactc cccctccggg ctttcgcccg ccctctctcc     60

ctcccttttt tgcccgccct ggccctgccc ctgcccctgc cccctcctct cagcccctcc    120

gcgcccgggg tgtcattggg cccgggagac gggagccaac ttcaggctgc tcagaggaag    180

cccgtgcagt cagtcacctg ggtgcaagag cgttgctgcc tcgggctctc ccgctgcagg    240

gagagcggca ctcgctggcc tggatgtggt tggatttagg ggggctccgc agcaggggtt    300

tcgtggcggt ggcaagcgct gcaacaggta gacggcgaga gacggacccc ggccgaggca    360

gcgatggaga ccaaaggcta ccacagtctc cctgaaggtc tagatatgga aagacggtgg    420

ggtcaagttt ctcaggctgt ggagcgttct tccctgggac ctacagagag gaccgatgag    480

aataactaca tggagattgt caacgtaagc tgtgtttccg gtgctattcc aaacaacagt    540

actcaaggaa gcagcaaaga aaaacaagaa ctactccctt gccttcagca agacaataat    600

cggcctggga ttttaacatc tgatattaaa actgagctgg aatctaagga actttcagca    660

actgtagctg agtccatggg tttatatatg gattctgtaa gagatgctga ctattcctat    720

gagcagcaga accaacaagg aagcatgagt ccagctaaga tttatcagaa tgttgaacag    780

ctggtgaaat tttacaaagg aaatggccat cgtccttcca ctctaagttg tgtgaacacg    840

cccttgagat catttatgtc tgactctggg agctccgtga atggtggcgt catgcgcgcc    900

gttgttaaaa gccctatcat gtgtcatgag aaaagcccgt ctgtttgcag ccctctgaac    960

atgacatctt cggtttgcag ccctgctgga atcaactctg tgtcctccac cacagccagc   1020

tttggcagtt ttccagtgca cagcccaatc acccagggaa ctcctctgac atgctcccct   1080

aatgttgaaa atcgaggctc caggtcgcac agccctgcac atgctagcaa tgtgggctct   1140

cctctctcaa gtccgttaag tagcatgaaa tcctcaattt ccagccctcc aagtcactgc   1200

agtgtaaaat ctccagtctc cagtcccaat aatgtcactc tgagatcctc tgtgtctagc   1260

cctgcaaata ttaacaactc aaggtgctct gtttccagcc cttcgaacac taataacaga   1320

tccacgcttt ccagtccggc agccagtact gtgggatcta tctgtagccc tgtaaacaat   1380

gccttcagct acactgcttc tggcacctct gctggatcca gtacattgcg ggatgtggtt   1440

cccagtccag acacgcagga gaaaggtgct caagaggtcc cttttcctaa gactgaggaa   1500

gtagagagtg ccatctcaaa tggtgtgact ggccagctta atattgtcca gtacataaaa   1560

ccagaaccag atggagcttt tagcagctca tgtctaggag gaaatagcaa aataaattcg   1620

gattcttcat tctcagtacc aataaagcaa gaatcaacca agcattcatg ttcaggcacc   1680

tcttttaaag ggaatccaac agtaaacccg tttccattta tggatggctc gtatttttcc   1740

tttatggatg ataaagacta ttattcccta tcaggaattt taggaccacc tgtgcccggc   1800

tttgatggta actgtgaagg cagcggattc ccagtgggta ttaaacaaga accagatgat   1860

gggagctatt acccagaggc cagcatccct tcctctgcta ttgttggggt gaattcaggt   1920

ggacagtcct tccactacag gattggtgct caaggtacaa tatctttatc acgatcggct   1980

agagaccaat ctttccaaca cctgagttcc tttcctcctg tcaatacttt agtggagtca   2040

tggaaatcac acggcgacct gtcgtctaga agaagtgatg ggtatccggt cttagaatac   2100

attccagaaa atgtatcaag ctctacttta cgaagtgttt ctactggatc ttcaagacct   2160

tcaaaaatat gtttggtgtg tggggatgag gcttcaggat gccattatgg ggtagtcacc   2220

tgtggcagct gcaaagtttt cttcaaaaga gcagtggaag ggcaacacaa ctatttatgt   2280

gctggaagaa atgattgcat cattgataag attcgacgaa agaattgtcc tgcttgcaga   2340

cttcagaaat gtcttcaagc tggaatgaat ttaggagcac gaaagtcaaa gaagttggga   2400

aagttaaaag ggattcacga ggagcagcca cagcagcagc agcccccacc cccaccccca   2460

cccccgcaaa gcccagagga agggacaacg tacatcgctc ctgcaaaaga accctcggtc   2520

aacacagcac tggttcctca gctctccaca atctcacgag cgctcacacc ttcccccgtt   2580

atggtccttg aaaacattga acctgaaatt gtatatgcag gctatgacag ctcaaaacca   2640

gatacagccg aaaatctgct ctccacgctc aaccgcttag caggcaaaca gatgatccaa   2700

gtcgtgaagt gggcaaaggt acttccagga tttaaaaact tgcctcttga ggaccaaatt   2760

accctaatcc agtattcttg gatgtgtcta tcatcatttg ccttgagctg gagatcgtac   2820

aaacatacga acagccaatt tctctatttt gcaccagacc tagtctttaa tgaagagaag   2880

atgcatcagt ctgccatgta tgaactatgc caggggatgc accaaatcag ccttcagttc   2940

gttcgactgc agctcacctt tgaagaatac accatcatga aagttttgct gctactaagc   3000

acaattccaa aggatggcct caaaagccag gctgcatttg aagaaatgag gacaaattac   3060

atcaaagaac tgaggaagat ggtaactaag tgtcccaaca attctgggca gagctggcag   3120

aggttctacc aactgaccaa gctgctggac tccatgcatg acctggtgag cgacctgctg   3180

gaattctgct tctacacctt ccgagagtcc catgcgctga aggtagagtt ccccgcaatg   3240

ctggtggaga tcatcagcga ccagctgccc aaggtggagt cggggaacgc caagccgctc   3300

tacttccacc ggaagtgact gcccgctgcc cagaagaact ttgccttaag tttccctgtg   3360

ttgttccaca cccagaagga cccaagaaaa cctgttttta acatgtgatg gttgattcac   3420

acttgttcaa cagtttctca agtttaaagt catgtcagag gtttggagcc gggaaagctg   3480

tttttccgtg gatttggcga gaccagagca gtctgaagga ttccccacct ccaatccccc   3540

agcgcttaga aacatgttcc tgttcctcgg gatgaaaagc catatctagt caataactct   3600

gattttgata ttttcacaga tggaagaagt tttaactatg ccgtgtagtt tctggtatcg   3660

ttcgcttgtt ttaaaagggt tcaaggacta acgaacgttt taaagcttac ccttggtttg   3720

cacataaaac gtatagtcaa tatggggcat taatattctt ttgttattaa aaaaacacaa   3780

aaaaataata aaaaaatata tacagattcc tgttgtgtaa taacagaact cgtggcgtgg   3840

ggcagcagct gcctctgagc cctcgctcgt ccacggtctt ctgcatcact ggtatacaca   3900

ctcgttagcg tccatttctt atttaattag aatggataag atgatgttaa atgccttggt   3960

ttgatttcta gtatctattg tgttggcttt acaaataatt ttttgcagtc ttttgctgtg   4020

ctgtacatta ctgtatgtat aaattatgaa ggacctgaaa taaggtataa ggatcttttg   4080

taaatgagac acatacaaaa aaaatcttta atggttaata ggatgaatgg gaaagtattt   4140

ttgaaagaat tctattttgc tggagactat ttaagtacta tctttgtcta aacaaggtaa   4200

tttttttttg taaagtgcaa tgtcctgcat gcataatgaa ccgtttacag tgtatttaag   4260

aaagggaaag ctgtgccttt tttagcttca tatctaattt accattattt tacagtctct   4320

gttgtaaata accacactga aacctcttcg gttgtcttga aacctttcta ctttttctgt   4380

actttttgtt ttgttcttgg tctcccgctt ggggcatttg tgggactcca gcacgttttc   4440

tggcttctgc ttcatcctgc tccatcgggg aatgacacac tgcggtgtct gcagctcctg   4500

gaaggtgtca tttgacaaca catgtgggag aggaggtcct tggagtgctg cagctttggg   4560

aaagctgcct cgtttccctt ttcctctaga agcagaacca gctctacgag agtgagactg   4620

ggaacttgat ggctcagaga gcatcttttc ctcccatttt agaaaatcag attttctcct   4680

gtgggaaaaa aaaattccat gcactctctc tctgttaaag atcagctatt cccttctgat   4740

cttggaaaga ggttctgcac tcctggaacc ggtcacagga acgcacagat catggcagga   4800

tgcgctggga cggcccatct tggcaaggtt cagtctgaat ggcatggaga ccgggagata   4860

gaggggtttt agatttttaa aaggtaggtt ttaaaaataa gttttataca taaacagttt   4920

tggagaaaaa ttacagatca tataagcaag acagtggcac taaaatgttt aattcattaa   4980

tctgtttgtt tggcactgat gcaatgtatg gcttttctct tgccccaaat cacaaacata   5040

tgtatctttg gggaaactaa caatatgatt gcactaaata aactactttg aatagaggcc   5100

aaattaatct tttaaaaatg atgataatca tcaggtttac tcagtgaaat catattaatt   5160

attttccaaa atctaaaagc tgtagctgga gaagcccatg gccacgagga agcagcaatt   5220

aattagatca acacttttct ccagggttca ccatgcaggc aacattacct tgtctttcaa   5280

aagacacctg ccttatgcaa ggggaaacct gtgaaagctg cactcagagg gaggagtttt   5340

tcttacataa tttgcaattt caggaattta atttataggc agatctttaa atacagtcaa   5400

cttacggtgc acagtaatat gaaagccaca ctttgaaggt aataaataca cagcatgcag   5460

actgggagtt gctagcaaac aaatggctta cttacaaaag cagcttttag ttcagactta   5520

gtttttataa aatgggaatt ctgacttact taaccaggtt tgggatggag atggtctgca   5580

tcagcttttt gtattaacaa agttactggc tctttgtgtg tctccaggta actttgcttg   5640

attaaacagc aaagccatat tctaaattca ctgttgaatg cctgtcccag tccaaattgt   5700

ctgtctgctc ttatttttgt accatattgc tcttaaaaat cttggtttgg tacagttcat   5760

aattcaccaa aagttcatat aatttaaaga aacactaaat tagtttaaaa tgaagcaatt   5820

tatatcttta tgcaaaaaca tatgtctgtc tttgcaaagg actgtaagca gattacaata   5880

aatcctttac tttaatcacc                                               5900


<210>  2589
<211>  984
<212>  PRT
<213>  Homo sapiens

<400>  2589

Met Glu Thr Lys Gly Tyr His Ser Leu Pro Glu Gly Leu Asp Met Glu 
1               5                   10                  15


Arg Arg Trp Gly Gln Val Ser Gln Ala Val Glu Arg Ser Ser Leu Gly 
            20                  25                  30


Pro Thr Glu Arg Thr Asp Glu Asn Asn Tyr Met Glu Ile Val Asn Val 
        35                  40                  45


Ser Cys Val Ser Gly Ala Ile Pro Asn Asn Ser Thr Gln Gly Ser Ser 
    50                  55                  60


Lys Glu Lys Gln Glu Leu Leu Pro Cys Leu Gln Gln Asp Asn Asn Arg 
65                  70                  75                  80


Pro Gly Ile Leu Thr Ser Asp Ile Lys Thr Glu Leu Glu Ser Lys Glu 
                85                  90                  95


Leu Ser Ala Thr Val Ala Glu Ser Met Gly Leu Tyr Met Asp Ser Val 
            100                 105                 110


Arg Asp Ala Asp Tyr Ser Tyr Glu Gln Gln Asn Gln Gln Gly Ser Met 
        115                 120                 125


Ser Pro Ala Lys Ile Tyr Gln Asn Val Glu Gln Leu Val Lys Phe Tyr 
    130                 135                 140


Lys Gly Asn Gly His Arg Pro Ser Thr Leu Ser Cys Val Asn Thr Pro 
145                 150                 155                 160


Leu Arg Ser Phe Met Ser Asp Ser Gly Ser Ser Val Asn Gly Gly Val 
                165                 170                 175


Met Arg Ala Val Val Lys Ser Pro Ile Met Cys His Glu Lys Ser Pro 
            180                 185                 190


Ser Val Cys Ser Pro Leu Asn Met Thr Ser Ser Val Cys Ser Pro Ala 
        195                 200                 205


Gly Ile Asn Ser Val Ser Ser Thr Thr Ala Ser Phe Gly Ser Phe Pro 
    210                 215                 220


Val His Ser Pro Ile Thr Gln Gly Thr Pro Leu Thr Cys Ser Pro Asn 
225                 230                 235                 240


Val Glu Asn Arg Gly Ser Arg Ser His Ser Pro Ala His Ala Ser Asn 
                245                 250                 255


Val Gly Ser Pro Leu Ser Ser Pro Leu Ser Ser Met Lys Ser Ser Ile 
            260                 265                 270


Ser Ser Pro Pro Ser His Cys Ser Val Lys Ser Pro Val Ser Ser Pro 
        275                 280                 285


Asn Asn Val Thr Leu Arg Ser Ser Val Ser Ser Pro Ala Asn Ile Asn 
    290                 295                 300


Asn Ser Arg Cys Ser Val Ser Ser Pro Ser Asn Thr Asn Asn Arg Ser 
305                 310                 315                 320


Thr Leu Ser Ser Pro Ala Ala Ser Thr Val Gly Ser Ile Cys Ser Pro 
                325                 330                 335


Val Asn Asn Ala Phe Ser Tyr Thr Ala Ser Gly Thr Ser Ala Gly Ser 
            340                 345                 350


Ser Thr Leu Arg Asp Val Val Pro Ser Pro Asp Thr Gln Glu Lys Gly 
        355                 360                 365


Ala Gln Glu Val Pro Phe Pro Lys Thr Glu Glu Val Glu Ser Ala Ile 
    370                 375                 380


Ser Asn Gly Val Thr Gly Gln Leu Asn Ile Val Gln Tyr Ile Lys Pro 
385                 390                 395                 400


Glu Pro Asp Gly Ala Phe Ser Ser Ser Cys Leu Gly Gly Asn Ser Lys 
                405                 410                 415


Ile Asn Ser Asp Ser Ser Phe Ser Val Pro Ile Lys Gln Glu Ser Thr 
            420                 425                 430


Lys His Ser Cys Ser Gly Thr Ser Phe Lys Gly Asn Pro Thr Val Asn 
        435                 440                 445


Pro Phe Pro Phe Met Asp Gly Ser Tyr Phe Ser Phe Met Asp Asp Lys 
    450                 455                 460


Asp Tyr Tyr Ser Leu Ser Gly Ile Leu Gly Pro Pro Val Pro Gly Phe 
465                 470                 475                 480


Asp Gly Asn Cys Glu Gly Ser Gly Phe Pro Val Gly Ile Lys Gln Glu 
                485                 490                 495


Pro Asp Asp Gly Ser Tyr Tyr Pro Glu Ala Ser Ile Pro Ser Ser Ala 
            500                 505                 510


Ile Val Gly Val Asn Ser Gly Gly Gln Ser Phe His Tyr Arg Ile Gly 
        515                 520                 525


Ala Gln Gly Thr Ile Ser Leu Ser Arg Ser Ala Arg Asp Gln Ser Phe 
    530                 535                 540


Gln His Leu Ser Ser Phe Pro Pro Val Asn Thr Leu Val Glu Ser Trp 
545                 550                 555                 560


Lys Ser His Gly Asp Leu Ser Ser Arg Arg Ser Asp Gly Tyr Pro Val 
                565                 570                 575


Leu Glu Tyr Ile Pro Glu Asn Val Ser Ser Ser Thr Leu Arg Ser Val 
            580                 585                 590


Ser Thr Gly Ser Ser Arg Pro Ser Lys Ile Cys Leu Val Cys Gly Asp 
        595                 600                 605


Glu Ala Ser Gly Cys His Tyr Gly Val Val Thr Cys Gly Ser Cys Lys 
    610                 615                 620


Val Phe Phe Lys Arg Ala Val Glu Gly Gln His Asn Tyr Leu Cys Ala 
625                 630                 635                 640


Gly Arg Asn Asp Cys Ile Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro 
                645                 650                 655


Ala Cys Arg Leu Gln Lys Cys Leu Gln Ala Gly Met Asn Leu Gly Ala 
            660                 665                 670


Arg Lys Ser Lys Lys Leu Gly Lys Leu Lys Gly Ile His Glu Glu Gln 
        675                 680                 685


Pro Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Gln Ser Pro 
    690                 695                 700


Glu Glu Gly Thr Thr Tyr Ile Ala Pro Ala Lys Glu Pro Ser Val Asn 
705                 710                 715                 720


Thr Ala Leu Val Pro Gln Leu Ser Thr Ile Ser Arg Ala Leu Thr Pro 
                725                 730                 735


Ser Pro Val Met Val Leu Glu Asn Ile Glu Pro Glu Ile Val Tyr Ala 
            740                 745                 750


Gly Tyr Asp Ser Ser Lys Pro Asp Thr Ala Glu Asn Leu Leu Ser Thr 
        755                 760                 765


Leu Asn Arg Leu Ala Gly Lys Gln Met Ile Gln Val Val Lys Trp Ala 
    770                 775                 780


Lys Val Leu Pro Gly Phe Lys Asn Leu Pro Leu Glu Asp Gln Ile Thr 
785                 790                 795                 800


Leu Ile Gln Tyr Ser Trp Met Cys Leu Ser Ser Phe Ala Leu Ser Trp 
                805                 810                 815


Arg Ser Tyr Lys His Thr Asn Ser Gln Phe Leu Tyr Phe Ala Pro Asp 
            820                 825                 830


Leu Val Phe Asn Glu Glu Lys Met His Gln Ser Ala Met Tyr Glu Leu 
        835                 840                 845


Cys Gln Gly Met His Gln Ile Ser Leu Gln Phe Val Arg Leu Gln Leu 
    850                 855                 860


Thr Phe Glu Glu Tyr Thr Ile Met Lys Val Leu Leu Leu Leu Ser Thr 
865                 870                 875                 880


Ile Pro Lys Asp Gly Leu Lys Ser Gln Ala Ala Phe Glu Glu Met Arg 
                885                 890                 895


Thr Asn Tyr Ile Lys Glu Leu Arg Lys Met Val Thr Lys Cys Pro Asn 
            900                 905                 910


Asn Ser Gly Gln Ser Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
        915                 920                 925


Asp Ser Met His Asp Leu Val Ser Asp Leu Leu Glu Phe Cys Phe Tyr 
    930                 935                 940


Thr Phe Arg Glu Ser His Ala Leu Lys Val Glu Phe Pro Ala Met Leu 
945                 950                 955                 960


Val Glu Ile Ile Ser Asp Gln Leu Pro Lys Val Glu Ser Gly Asn Ala 
                965                 970                 975


Lys Pro Leu Tyr Phe His Arg Lys 
            980


<210>  2590
<211>  3272
<212>  DNA
<213>  Homo sapiens

<400>  2590
aaaagggcca gccctccagc tggcccactc cccctccggg ctttcgcccg ccctctctcc     60

ctcccttttt tgcccgccct ggccctgccc ctgcccctgc cccctcctct cagcccctcc    120

gcgcccgggg tgtcattggg cccgggagac gggagccaac ttcaggctgc tcagaggaag    180

cccgtgcagt cagtcacctg ggtgcaagag cgttgctgcc tcgggctctc ccgctgcagg    240

gagagcggca ctcgctggcc tggatgtggt tggatttagg ggggctccgc agcaggggtt    300

tcgtggcggt ggcaagcgct gcaacaggta gacggcgaga gacggacccc ggccgaggca    360

gcgatggaga ccaaaggcta ccacagtctc cctgaaggtc tagatatgga aagacggtgg    420

ggtcaagttt ctcaggctgt ggagcgttct tccctgggac ctacagagag gaccgatgag    480

aataactaca tggagattgt caacgtaagc tgtgtttccg gtgctattcc aaacaacagt    540

actcaaggaa gcagcaaaga aaaacaagaa ctactccctt gccttcagca agacaataat    600

cggcctggga ttttaacatc tgatattaaa actgagctgg aatctaagga actttcagca    660

actgtagctg agtccatggg tttatatatg gattctgtaa gagatgctga ctattcctat    720

gagcagcaga accaacaagg aagcatgagt ccagctaaga tttatcagaa tgttgaacag    780

ctggtgaaat tttacaaagg aaatggccat cgtccttcca ctctaagttg tgtgaacacg    840

cccttgagat catttatgtc tgactctggg agctccgtga atggtggcgt catgcgcgcc    900

gttgttaaaa gccctatcat gtgtcatgag aaaagcccgt ctgtttgcag ccctctgaac    960

atgacatctt cggtttgcag ccctgctgga atcaactctg tgtcctccac cacagccagc   1020

tttggcagtt ttccagtgca cagcccaatc acccagggaa ctcctctgac atgctcccct   1080

aatgttgaaa atcgaggctc caggtcgcac agccctgcac atgctagcaa tgtgggctct   1140

cctctctcaa gtccgttaag tagcatgaaa tcctcaattt ccagccctcc aagtcactgc   1200

agtgtaaaat ctccagtctc cagtcccaat aatgtcactc tgagatcctc tgtgtctagc   1260

cctgcaaata ttaacaactc aaggtgctct gtttccagcc cttcgaacac taataacaga   1320

tccacgcttt ccagtccggc agccagtact gtgggatcta tctgtagccc tgtaaacaat   1380

gccttcagct acactgcttc tggcacctct gctggatcca gtacattgcg ggatgtggtt   1440

cccagtccag acacgcagga gaaaggtgct caagaggtcc cttttcctaa gactgaggaa   1500

gtagagagtg ccatctcaaa tggtgtgact ggccagctta atattgtcca gtacataaaa   1560

ccagaaccag atggagcttt tagcagctca tgtctaggag gaaatagcaa aataaattcg   1620

gattcttcat tctcagtacc aataaagcaa gaatcaacca agcattcatg ttcaggcacc   1680

tcttttaaag ggaatccaac agtaaacccg tttccattta tggatggctc gtatttttcc   1740

tttatggatg ataaagacta ttattcccta tcaggaattt taggaccacc tgtgcccggc   1800

tttgatggta actgtgaagg cagcggattc ccagtgggta ttaaacaaga accagatgat   1860

gggagctatt acccagaggc cagcatccct tcctctgcta ttgttggggt gaattcaggt   1920

ggacagtcct tccactacag gattggtgct caaggtacaa tatctttatc acgatcggct   1980

agagaccaat ctttccaaca cctgagttcc tttcctcctg tcaatacttt agtggagtca   2040

tggaaatcac acggcgacct gtcgtctaga agaagtgatg ggtatccggt cttagaatac   2100

attccagaaa atgtatcaag ctctacttta cgaagtgttt ctactggatc ttcaagacct   2160

tcaaaaatat gtttggtgtg tggggatgag gcttcaggat gccattatgg ggtagtcacc   2220

tgtggcagct gcaaagtttt cttcaaaaga gcagtggaag ggcaacacaa ctatttatgt   2280

gctggaagaa atgattgcat cattgataag attcgacgaa agaattgtcc tgcttgcaga   2340

cttcagaaat gtcttcaagc tggaatgaat ttaggagaga gaagatgcat cagtctgcca   2400

tgtatgaact atgccagggg atgcaccaaa tcagccttca gttcgttcga ctgcagctca   2460

cctttgaaga atacaccatc atgaaagttt tgctgctact aagcacaatt ccaaaggatg   2520

gcctcaaaag ccaggctgca tttgaagaaa tgaggacaaa ttacatcaaa gaactgagga   2580

agatggtaac taagtgtccc aacaattctg ggcagagctg gcagaggttc taccaactga   2640

ccaagctgct ggactccatg catgacctgg tgagcgacct gctggaattc tgcttctaca   2700

ccttccgaga gtcccatgcg ctgaaggtag agttccccgc aatgctggtg gagatcatca   2760

gcgaccagct gcccaaggtg gagtcgggga acgccaagcc gctctacttc caccggaagt   2820

gactgcccgc tgcccagaag aactttgcct taagtttccc tgtgttgttc cacacccaga   2880

aggacccaag aaaacctgtt tttaacatgt gatggttgat tcacacttgt tcaacagttt   2940

ctcaagttta aagtcatgtc agaggtttgg agccgggaaa gctgtttttc cgtggatttg   3000

gcgagaccag agcagtctga aggattcccc acctccaatc ccccagcgct tagaaacatg   3060

ttcctgttcc tcgggatgaa aagccatatc tagtcaataa ctctgatttt gatattttca   3120

cagatggaag aagttttaac tatgccgtgt agtttctggt atcgttcgct tgttttaaaa   3180

gggttcaagg actaacgaac gttttaaagc ttacccttgg tttgcacata aaacgtatag   3240

tcaatatggg gcattaatat tcttttgtta tt                                 3272


<210>  2591
<211>  706
<212>  PRT
<213>  Homo sapiens

<400>  2591

Met Glu Thr Lys Gly Tyr His Ser Leu Pro Glu Gly Leu Asp Met Glu 
1               5                   10                  15


Arg Arg Trp Gly Gln Val Ser Gln Ala Val Glu Arg Ser Ser Leu Gly 
            20                  25                  30


Pro Thr Glu Arg Thr Asp Glu Asn Asn Tyr Met Glu Ile Val Asn Val 
        35                  40                  45


Ser Cys Val Ser Gly Ala Ile Pro Asn Asn Ser Thr Gln Gly Ser Ser 
    50                  55                  60


Lys Glu Lys Gln Glu Leu Leu Pro Cys Leu Gln Gln Asp Asn Asn Arg 
65                  70                  75                  80


Pro Gly Ile Leu Thr Ser Asp Ile Lys Thr Glu Leu Glu Ser Lys Glu 
                85                  90                  95


Leu Ser Ala Thr Val Ala Glu Ser Met Gly Leu Tyr Met Asp Ser Val 
            100                 105                 110


Arg Asp Ala Asp Tyr Ser Tyr Glu Gln Gln Asn Gln Gln Gly Ser Met 
        115                 120                 125


Ser Pro Ala Lys Ile Tyr Gln Asn Val Glu Gln Leu Val Lys Phe Tyr 
    130                 135                 140


Lys Gly Asn Gly His Arg Pro Ser Thr Leu Ser Cys Val Asn Thr Pro 
145                 150                 155                 160


Leu Arg Ser Phe Met Ser Asp Ser Gly Ser Ser Val Asn Gly Gly Val 
                165                 170                 175


Met Arg Ala Val Val Lys Ser Pro Ile Met Cys His Glu Lys Ser Pro 
            180                 185                 190


Ser Val Cys Ser Pro Leu Asn Met Thr Ser Ser Val Cys Ser Pro Ala 
        195                 200                 205


Gly Ile Asn Ser Val Ser Ser Thr Thr Ala Ser Phe Gly Ser Phe Pro 
    210                 215                 220


Val His Ser Pro Ile Thr Gln Gly Thr Pro Leu Thr Cys Ser Pro Asn 
225                 230                 235                 240


Val Glu Asn Arg Gly Ser Arg Ser His Ser Pro Ala His Ala Ser Asn 
                245                 250                 255


Val Gly Ser Pro Leu Ser Ser Pro Leu Ser Ser Met Lys Ser Ser Ile 
            260                 265                 270


Ser Ser Pro Pro Ser His Cys Ser Val Lys Ser Pro Val Ser Ser Pro 
        275                 280                 285


Asn Asn Val Thr Leu Arg Ser Ser Val Ser Ser Pro Ala Asn Ile Asn 
    290                 295                 300


Asn Ser Arg Cys Ser Val Ser Ser Pro Ser Asn Thr Asn Asn Arg Ser 
305                 310                 315                 320


Thr Leu Ser Ser Pro Ala Ala Ser Thr Val Gly Ser Ile Cys Ser Pro 
                325                 330                 335


Val Asn Asn Ala Phe Ser Tyr Thr Ala Ser Gly Thr Ser Ala Gly Ser 
            340                 345                 350


Ser Thr Leu Arg Asp Val Val Pro Ser Pro Asp Thr Gln Glu Lys Gly 
        355                 360                 365


Ala Gln Glu Val Pro Phe Pro Lys Thr Glu Glu Val Glu Ser Ala Ile 
    370                 375                 380


Ser Asn Gly Val Thr Gly Gln Leu Asn Ile Val Gln Tyr Ile Lys Pro 
385                 390                 395                 400


Glu Pro Asp Gly Ala Phe Ser Ser Ser Cys Leu Gly Gly Asn Ser Lys 
                405                 410                 415


Ile Asn Ser Asp Ser Ser Phe Ser Val Pro Ile Lys Gln Glu Ser Thr 
            420                 425                 430


Lys His Ser Cys Ser Gly Thr Ser Phe Lys Gly Asn Pro Thr Val Asn 
        435                 440                 445


Pro Phe Pro Phe Met Asp Gly Ser Tyr Phe Ser Phe Met Asp Asp Lys 
    450                 455                 460


Asp Tyr Tyr Ser Leu Ser Gly Ile Leu Gly Pro Pro Val Pro Gly Phe 
465                 470                 475                 480


Asp Gly Asn Cys Glu Gly Ser Gly Phe Pro Val Gly Ile Lys Gln Glu 
                485                 490                 495


Pro Asp Asp Gly Ser Tyr Tyr Pro Glu Ala Ser Ile Pro Ser Ser Ala 
            500                 505                 510


Ile Val Gly Val Asn Ser Gly Gly Gln Ser Phe His Tyr Arg Ile Gly 
        515                 520                 525


Ala Gln Gly Thr Ile Ser Leu Ser Arg Ser Ala Arg Asp Gln Ser Phe 
    530                 535                 540


Gln His Leu Ser Ser Phe Pro Pro Val Asn Thr Leu Val Glu Ser Trp 
545                 550                 555                 560


Lys Ser His Gly Asp Leu Ser Ser Arg Arg Ser Asp Gly Tyr Pro Val 
                565                 570                 575


Leu Glu Tyr Ile Pro Glu Asn Val Ser Ser Ser Thr Leu Arg Ser Val 
            580                 585                 590


Ser Thr Gly Ser Ser Arg Pro Ser Lys Ile Cys Leu Val Cys Gly Asp 
        595                 600                 605


Glu Ala Ser Gly Cys His Tyr Gly Val Val Thr Cys Gly Ser Cys Lys 
    610                 615                 620


Val Phe Phe Lys Arg Ala Val Glu Gly Gln His Asn Tyr Leu Cys Ala 
625                 630                 635                 640


Gly Arg Asn Asp Cys Ile Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro 
                645                 650                 655


Ala Cys Arg Leu Gln Lys Cys Leu Gln Ala Gly Met Asn Leu Gly Glu 
            660                 665                 670


Arg Arg Cys Ile Ser Leu Pro Cys Met Asn Tyr Ala Arg Gly Cys Thr 
        675                 680                 685


Lys Ser Ala Phe Ser Ser Phe Asp Cys Ser Ser Pro Leu Lys Asn Thr 
    690                 695                 700


Pro Ser 
705


<210>  2592
<211>  669
<212>  DNA
<213>  Homo sapiens

<400>  2592
ggcccgggga gaactctcac tgaggacaac tggacagcgc cagcacactg acccagcgac     60

tggggacaca aagaaacaga ttatggttga cactgtgggg acctgaaacc aaggagcatg    120

aaaccactga caaacgggga actactgtac acttaaaatg cctagaacca tgtgtggaac    180

acaactggcg ctcaacaaac tttctactct tccccaaggt cacagccctt gagatcagga    240

agcaccttag tgcaatggca gagcactgtt ccgggagcag atggcttggt tcctgtctgg    300

tttcaccact cactgactgt gagagctaca gttagccaca ccaagctcta cccagtccca    360

agactggggc tctgacacct gcctttcttg agagcctacc tgctgagatt tctaaatgca    420

gtctcctcct acacccaaag actctcatga tgtcctactc agaccaccag cagtttctgc    480

actctgcctt ctgggctgga cttccttgtg acacctgtac ccatactcca gatattatcc    540

caccttggtc tgattcatat cctaggcctt tccagtttgt cccattatta ccttaatttc    600

caaagaaata tttcctgtca ccatttcttg tatatagaag gaaaataata ataaaataat    660

acaatagag                                                            669


<210>  2593
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  2593

Met Met Ser Tyr Ser Asp His Gln Gln Phe Leu His Ser Ala Phe Trp 
1               5                   10                  15


Ala Gly Leu Pro Cys Asp Thr Cys Thr His Thr Pro Asp Ile Ile Pro 
            20                  25                  30


Pro Trp Ser Asp Ser Tyr Pro Arg Pro Phe Gln Phe Val Pro Leu Leu 
        35                  40                  45


Pro 



<210>  2594
<211>  8912
<212>  DNA
<213>  Homo sapiens

<400>  2594
atgagactgg atgagataac gaaatcagag aatgaagacg gagaaaagaa gatgtttact     60

cagcagtttg aaagtactga tgcctgtgta tatgaggtgt atgtgaaaat aaattccatt    120

gtgaaatctc agagtcagtg tggattgaaa agaggtagtc ccgagactga gctctggggt    180

gctatagtgt tcagaagcca ggaagagaac gcaaaaccag tgaaggaaac tgaggtgaca    240

gcctctgatg cagattcagg actctatggc tttattgaat attctcttta tgatggattc    300

ctgagctatg aagcacctca ggcattccgg atcgaccctc atgatgggca aatctgtgtt    360

tctcaagata tcgacaggga aagggatcca gctacctatg atctcctggt ggaagctaag    420

gatggggatg agcagagaat gacacattta gccctggtga agggtgggct aagtgcccaa    480

gcctttgttc gtgtggacct ggaggacgtg aatgataatc atcctgtgtt taacccatca    540

acctatgtga cgagcatcag tgatgagacc cagccaggca ccgagatcat caatgttctt    600

gccactgacc aggactctgg gatatatggg acagtggctt atgagcttat tccaggaaac    660

gtgtcgtccc tttttaccat tgactccacc acaggactct atagtccaga ggtagaaatt    720

ctgagtgctg tcaacttttc agcagacaag gaagtaatga acagtttaga gatgttttta    780

cctctgctaa ggcacttcaa gaaggttgaa agagatgagg aagctgcaga aaaaaaattt    840

gaagctagca gaggttggtt catgaggttt aagggaagac gccatctcca ttacctaaaa    900

gtgcaagatg aagcagcaag tgctgatgga gaagctgcag caaggtatgt agcaaatcta    960

gctaagattc ttggtgaagg aattatttac ttaacattac ctcttagtca tttggaatct   1020

accacacttt cgttgatggt ctctgctcaa gacggtggtg ggctcacagc tgtcattaat   1080

gccgatgtca ccatacacat tttccagaca actctggcac ctgctgagtt tgaaaggcct   1140

aagtacactt tcttagttta tgaagatgtg cctgaagata gtcccattgg aacagtgaaa   1200

gcaagagagc ccttgaactc ctcagaacca atcttttaca ggatttcttc tggtgatctc   1260

ggcggaaagt tctccattca cccgcggctg ggcactattc gcacccggaa gcccctggat   1320

cacgagacgc agcccgtggt tgtgctcacg gtgcaggcgc agctcggcag cgccccagcc   1380

tgcagcagca ccgaggtcaa cataacagtc atggatgtca atgacaacca cccagcgttc   1440

ctcaggacct cggatgagat tagaatatcc cagaccacgc cccctggcac agccttgtac   1500

ctcgcacgtg cggaagacag agacagtggg cggaacggac tcatccggta ctccatcgcc   1560

agcccgcagc caggcgtctt tgccatcgac agagccctgg gggtgctgtt cctcaacggc   1620

agcctgggcg cgggcgagca gcgggagctc acgctgactc tcagggccga ggaccaaggc   1680

gtgcatcctc aggcagccct gctggtgctg acagtcgtta tcgagaaacg cgaacacagc   1740

ccatcctgga ctttcgaaca tttggtctat caagtggaag tcagtgagtc tctctcaccg   1800

atgacacaaa tgctgcaaac acaggcgcac ccacttggcc cccagcgtgc agcctcgcct   1860

cttaggtact cgctggaacc cagcgtagac tctgctatgt ttggaatccg cccttacacg   1920

ggctggattt atttgcggcg acagtttgac tatgaatcca cccaaacata taattttaga   1980

gtgtttgctt ggatccccga ggacggattc ttgcaaaatg tgagcactac agtcattgtt   2040

cgtgtctggg atgagaatga caattccccc accttcttgc atgatgtgtt gtttttgaaa   2100

gtcgaagaga gccctgttcc ccaaggggta ataggcaaaa ttacagctat tgacatggac   2160

tctggaaaga atggacagct attatatttc cttttgtctg atggaaaatt cttcaagatg   2220

aatcctaata caggtccagc aggcaccatc tatgtcataa cctgggcaga tggtgctgct   2280

gcctttagtg ggacagactt tgcattcagt tctgatgaac ttcaagcctt tgttctcaag   2340

tctctgttct gtgaattagg agaaggagag ttaatcaatt gggtggcact ggatcgtgag   2400

caccgggggc accatgagat gactgtgcta gtgacagacc gcggctcccc accacgaaac   2460

gccaccatgg cggtttacgt ctcagttact gacatcaatg ataacaggcc cttcttcccc   2520

cagtgtctcc ctggaaagga gttacacgtg aaggttctgg aaggtcaacc agtaaatatg   2580

ttggttacaa ctgtgtttgc aaaggatcct gatgaaggaa ataatgcaga agttacatac   2640

tcagtatctt cagaagatag ttctgatcac tttaagattg acgccaacaa tggtgaaata   2700

agaacaacca caatactttc gtatgattat agaccttcct acagaatgag tgtcattgcc   2760

actgaccagg gagtgcctcc tcttcaagga caggcagttg ttaatattca ggtgatccca   2820

ctatccaaag ggagagcaat catgtctcag aatattagac atttaattat accagaaaat   2880

ttgaagccca caaaaataat gagcttgata aagtcatctg atcaccttca acaacattat   2940

aatggaaagt tacattttag tattgttgca gatgataagg atggacactt tgaaatagac   3000

agctcaaccg gagacttgtt tctttctaag gaacttgatt atgagacgac atctcattat   3060

cttttcagag tgattactac agaccatagc aaaaaccttt ccctgagtag cacagtcttc   3120

cttagtatcg atgtggaaga tcagaatgac cattccccat ctttccagga tgagctcatt   3180

gtgatcagtg tagaggagaa tgttcccata ggaaccctgg tgtatgtctt caatgccaaa   3240

gatgatgacg gcagtttttt gaacagtaga atacaatact acattgaatc ccacaaccct   3300

ggcacgaatc catttctcat ccacccctca tttggcacac tagtcactgt gtcccgtctt   3360

gacagagaaa gcattccaac tgtcatcctg acagtaacag catctgatca ggctgtgaat   3420

gtgacagacc ggcgactgag atcactgaca gcacaaatag tgattttgga tgtaaatgac   3480

cacaacccca cttttatttc tttccccaat gcccatgtca aagaggatgt cacagtgggc   3540

tccttggtcc accacataac tgctcacgat ccagacgaag gaaggaatgg aaaagtaaca   3600

tacagcatcc tctcaggaaa tgaaaacatg acgtttatgc tagatgagtc atcaggctta   3660

ctaaccacaa cctgtccttt ggattatgaa atgaaaactc agcatattct gactgttctg   3720

gcactggatg atggcacacc agcactttct tcatcccaga ctttgacagt tactgttctt   3780

gatgtaaatg atgaagctcc agtatttaag cagcacctgt atgaagcctc agtgaaagaa   3840

aaccaaaatc caggggagtt tgttaccagg gttgaagctc tggacagaga ttcaggagtc   3900

aattccaagc ttcagtttga aatcatgcca ggtgcttcat ttgaattatt cgagataaat   3960

tctgacactg gagaggtagt gacaaccacc atacttgaca gagaaattca agaagtcttc   4020

acccttcgag tactagtacg agatggggga ttcccttcat tgtccagcac cacaacaatc   4080

ctctgcactg ttgaagatga aaacgatcac gcaccagagt ttattgtttc cagttatgac   4140

attgaggttc tggaaaacca ggaaccagag gttgtctata cggttttagc ctctgatatg   4200

gatgctggca ataacagagc tgttgaatat cacataattg atggaaatac tgatgagtgc   4260

tttactataa atgagatgtc aggagaactc tcaaccactc gtgctttgga ccgggagcaa   4320

atcagcaatt ttacccttgt cattctgtgc tctgacctgg gagatccacc taggagctct   4380

gtaatacacc tgcaagttag agttttggat gccaatgacc acagtccttc ttttcccaca   4440

ctttattacc agtcctctgt gagagaagat gctgaagtgg gaacagtggt tcttgtgctt   4500

tcagctgtgg acaaggatga aggcctgaat gggcaaactg agtattttct gactgatgag   4560

gcttctggtg cattcaccat tgatcctatg tcaggcacat tgaaaaccag caacaccctc   4620

gaccgtgaag ccagatctca gcatacattt agtgctgtgg ccagagactg tagcatccag   4680

ggttcacgaa gcaccactgt aattataaaa gtatatgtca ctgatgttaa tgacaatgat   4740

ccagttttgg aacagaaccc ttttgatgtg tttctttccc ccgagtcgcc tacaaaccag   4800

acaactgtca ttgtgagagc tgatgacctg gacttggggc ccaatggaac tgtggttttt   4860

agttttgcag agacccagtc aatgttttct attgataaat acacaggaga aattcaattt   4920

cagcaaaatc catcttcaga atacttccct atctggctgc agttaaaagt tacagaccag   4980

ggcattccag ccaggacaac cacgggtctc ttggtcattc acatggaagg agaagatgta   5040

aagatttcct tcagccacca cctgtataaa gggctcgtga ctgaaaattg tgaggcaggt   5100

acttctattg tgactgttaa agcttttgct cctgactcaa ttcaggacag catgaaatat   5160

tcaattttta gtggaaatga agatggagtt ctttccctgt gctctaagtc aggacaactc   5220

actgtgaaag aacccaagtt tcttgatttt gaagtcagaa atgaggttca actcatcgtt   5280

ttagctgaaa gtagtgggca tagagcctat tgcaaagtag cagtcttgat acaggatgag   5340

aatgataatt caccatgctt tgaacaaagc atttaccagg catcagtgtc tgaaagccaa   5400

ctctacaatg ctcatgtcat acaggttttt gctaccgact tggacagtgg tttgaacggc   5460

ctgattgagt attctattct gtctggcaac caagaagaag cattccagat tgatgcactg   5520

agtggtgtga taacaacaaa agcgattcta gattacgagc tcaccagctc ctacagcttg   5580

attgtccaag ccacagataa agggatgccc aggctttcta atacgactgt aatcaaggta   5640

caggtgactg atataaatga caatgcccca gcttttctcc cctctgaagc agtggaaatt   5700

acagaagatt ctttgcctgg tgtaattgtg actcatgtgt cagttcatga tgtggatttg   5760

aattcagctt tcatattcag ttttgccaaa gagagtaatc ctggaaccaa gtttgctatt   5820

gatcagaaca ctggagtggt ggtgttggtg aaaacattgg attttgaaga aatgactgaa   5880

tatgagctgc tcatccaaat ttctgattca gtgcactaca cagagggagc acttgtagtc   5940

cgtgtgctgg atgtcaatga taatccacca gtgttttctc aagatttcta tcaggtcaca   6000

gttcctgaat caatacctgt ggggtattca gtgctgactc tgtcagccac agacttagaa   6060

agcaatgaga acatttctta cagaattcta tcctcttcta aggaattctc cattgatcct   6120

aagaatggca caatatttac tatcagtccc gtattacttc tggatacaat atcaacaact   6180

caatttcttg tggaagccag tgatggtgga aatcctgacc tgagagctct tactttagtg   6240

gagataggaa tagaagatat gaacaattat gcccctgaat tcacagtcaa atcctataat   6300

cttagcctaa gtgaggatgc tctggttgga agcacgcttg ttacattttc aaacatcgac   6360

catgactgga cccgtgaaaa cacatatgtt gaatattcca tcatcagtgg taattcacag   6420

aacaattttc atgtggaaac taagttcttt cattcagaat atccttataa gcaagtcggt   6480

tatcttgtgt tgcttcacag tctggacaga gaagcaagtg ctagccatga gcttgtcatt   6540

ctggcatctg acagtggctg ccctccattg agttccacag ctgtcatatc aatacaagta   6600

cttgatgtca atgacaatcc cccaaacttc agcagcctga gctatcacac ccatgtcaag   6660

gaaagcaccc ctctagggag tcacatcact gtggtctcag caaatgaccg tgacacaggg   6720

tcacatgcag aaatcatcta caacatcatc tctggaaatg agaagggaca tttttactta   6780

gaagaaaaca ctggagttct ttatttgatt aaacctctgg attatgaaaa aatgacaaaa   6840

ttcaccttaa ctgtccaagc ttcagatgca gaaaagaaac atttttcttt tgcagttgtg   6900

tttgtcagtg tcctggatga taacgaccat gcacctcagt ttatgttctc aagcttcagc   6960

tgtattgttc cagaaaatct gcctatttcc tctaccatat gctctataaa tgctctggat   7020

tttgatgctg gtccgtatgg agaattgacc tattctattg tatcaccctg ttttctcact   7080

catggaatgt cttatgatca tgatctcttc ctcattgacc ctttgacagg ggatattcat   7140

gctaagcaaa tccttgacta tgaaaatggc aataaatact gcctcacagt ccaagccaaa   7200

gacaaaggtg atgcaactgc ctccttagtg gtctgggtgg atattgaagg gatagatgaa   7260

tttgagccca ttttcactca agatcagtat tttttcaccc tcccagaaaa gaataaagac   7320

agacagttga ttggcagagt ggaagcctca gatgcagatg ctggtattga tggagtcatt   7380

ctttactccc ttggaacctc atctcctttc ttttcagtaa ataaaaccaa tggaaatatt   7440

tatttgatta gagcccttcc cctaataaaa agtcaactca acaaagaaga caccttggaa   7500

atgaaaataa tcgctcatag tcccaaatca gattccaagt ttgcatcttg cactgttttt   7560

gtgaatgtgt ctttctcctc tgaaggaaca cccttggcag tgttcgccag cagcttttca   7620

atcagcctgg tggtctcctt tttagtgttt ctgatactca tctgcattct aattgtaatg   7680

attttaagac ataaacaaaa agacacaata aacaattatg aggagaagaa aacctcatct   7740

ttagatgcgg acttgagagt gacccgggat gccagtgtgc tcaaagcctt ccagaaaact   7800

gacgactgca gtaacgaggt ggtccctgtg gatgccactc cggaatggtt gagtttaata   7860

agtatcatgg agaaggatat tgtcaatctg tacagacact caaactccag tggccactgt   7920

tctgtggaag gagaaactgc agaagataag gaaatccaga ggataaatga gcatccctac   7980

agaaagtgct cagactcagc tctgagtgac cacgagtcca gggtgccaga ctcgggtatc   8040

ccgagggact cagaccagct ctcctgccta tctggggaaa ctgatgtgat ggtgactgcc   8100

gaaacagcag aagccagcca aacatttggg gaaggagatc aaggggaagg ctgcagcacc   8160

acctgtgctc aaaataatgt gttaccccag acagttcaga agagagaggc aaaagagagc   8220

atcctggctg acgttagaaa agagtctgtc tttatttcag gtgatcagga agtaaggtgt   8280

gcagctcttt caactcagac gacctctgat catgatggaa aagacaacta tcactggaat   8340

tatcttctta gttgggagcc caaattccaa cctcttgcct cagtatttaa tgatattgca   8400

aaactaaagg atgaacattt gcatatgcct ggcattccaa aagagaagaa atcttttgtt   8460

tttccacccc ctttgataac agcagtagcc cagcctggga ttaaagcagt cccaccaaga   8520

atgccggcag taaacctggg gcaggtgcct ccgaaacacc cacgctctcc catcccctac   8580

catcttggtt ctctgccaga aggcatgact cccaattttt ctccatctct ttccctattg   8640

acgatgcagc ctcctgcctt gtctccactg ttgagagaag gagaattatt aggaacacac   8700

atcagtggta catgccatga acttaaagca gaagatgaag ttcaaatatg aaaccactgg   8760

gatgccaagt acctgctcac cattggtcat gaatgaatga acaaaatgtt ttcaagccag   8820

caactcgaga ttgggctcat ttttatctaa aagcaagtga tgtaatttag ttagagtttt   8880

taaaacttcc ccattaaagt ttctccaatt tc                                 8912


<210>  2595
<211>  2916
<212>  PRT
<213>  Homo sapiens

<400>  2595

Met Arg Leu Asp Glu Ile Thr Lys Ser Glu Asn Glu Asp Gly Glu Lys 
1               5                   10                  15


Lys Met Phe Thr Gln Gln Phe Glu Ser Thr Asp Ala Cys Val Tyr Glu 
            20                  25                  30


Val Tyr Val Lys Ile Asn Ser Ile Val Lys Ser Gln Ser Gln Cys Gly 
        35                  40                  45


Leu Lys Arg Gly Ser Pro Glu Thr Glu Leu Trp Gly Ala Ile Val Phe 
    50                  55                  60


Arg Ser Gln Glu Glu Asn Ala Lys Pro Val Lys Glu Thr Glu Val Thr 
65                  70                  75                  80


Ala Ser Asp Ala Asp Ser Gly Leu Tyr Gly Phe Ile Glu Tyr Ser Leu 
                85                  90                  95


Tyr Asp Gly Phe Leu Ser Tyr Glu Ala Pro Gln Ala Phe Arg Ile Asp 
            100                 105                 110


Pro His Asp Gly Gln Ile Cys Val Ser Gln Asp Ile Asp Arg Glu Arg 
        115                 120                 125


Asp Pro Ala Thr Tyr Asp Leu Leu Val Glu Ala Lys Asp Gly Asp Glu 
    130                 135                 140


Gln Arg Met Thr His Leu Ala Leu Val Lys Gly Gly Leu Ser Ala Gln 
145                 150                 155                 160


Ala Phe Val Arg Val Asp Leu Glu Asp Val Asn Asp Asn His Pro Val 
                165                 170                 175


Phe Asn Pro Ser Thr Tyr Val Thr Ser Ile Ser Asp Glu Thr Gln Pro 
            180                 185                 190


Gly Thr Glu Ile Ile Asn Val Leu Ala Thr Asp Gln Asp Ser Gly Ile 
        195                 200                 205


Tyr Gly Thr Val Ala Tyr Glu Leu Ile Pro Gly Asn Val Ser Ser Leu 
    210                 215                 220


Phe Thr Ile Asp Ser Thr Thr Gly Leu Tyr Ser Pro Glu Val Glu Ile 
225                 230                 235                 240


Leu Ser Ala Val Asn Phe Ser Ala Asp Lys Glu Val Met Asn Ser Leu 
                245                 250                 255


Glu Met Phe Leu Pro Leu Leu Arg His Phe Lys Lys Val Glu Arg Asp 
            260                 265                 270


Glu Glu Ala Ala Glu Lys Lys Phe Glu Ala Ser Arg Gly Trp Phe Met 
        275                 280                 285


Arg Phe Lys Gly Arg Arg His Leu His Tyr Leu Lys Val Gln Asp Glu 
    290                 295                 300


Ala Ala Ser Ala Asp Gly Glu Ala Ala Ala Arg Tyr Val Ala Asn Leu 
305                 310                 315                 320


Ala Lys Ile Leu Gly Glu Gly Ile Ile Tyr Leu Thr Leu Pro Leu Ser 
                325                 330                 335


His Leu Glu Ser Thr Thr Leu Ser Leu Met Val Ser Ala Gln Asp Gly 
            340                 345                 350


Gly Gly Leu Thr Ala Val Ile Asn Ala Asp Val Thr Ile His Ile Phe 
        355                 360                 365


Gln Thr Thr Leu Ala Pro Ala Glu Phe Glu Arg Pro Lys Tyr Thr Phe 
    370                 375                 380


Leu Val Tyr Glu Asp Val Pro Glu Asp Ser Pro Ile Gly Thr Val Lys 
385                 390                 395                 400


Ala Arg Glu Pro Leu Asn Ser Ser Glu Pro Ile Phe Tyr Arg Ile Ser 
                405                 410                 415


Ser Gly Asp Leu Gly Gly Lys Phe Ser Ile His Pro Arg Leu Gly Thr 
            420                 425                 430


Ile Arg Thr Arg Lys Pro Leu Asp His Glu Thr Gln Pro Val Val Val 
        435                 440                 445


Leu Thr Val Gln Ala Gln Leu Gly Ser Ala Pro Ala Cys Ser Ser Thr 
    450                 455                 460


Glu Val Asn Ile Thr Val Met Asp Val Asn Asp Asn His Pro Ala Phe 
465                 470                 475                 480


Leu Arg Thr Ser Asp Glu Ile Arg Ile Ser Gln Thr Thr Pro Pro Gly 
                485                 490                 495


Thr Ala Leu Tyr Leu Ala Arg Ala Glu Asp Arg Asp Ser Gly Arg Asn 
            500                 505                 510


Gly Leu Ile Arg Tyr Ser Ile Ala Ser Pro Gln Pro Gly Val Phe Ala 
        515                 520                 525


Ile Asp Arg Ala Leu Gly Val Leu Phe Leu Asn Gly Ser Leu Gly Ala 
    530                 535                 540


Gly Glu Gln Arg Glu Leu Thr Leu Thr Leu Arg Ala Glu Asp Gln Gly 
545                 550                 555                 560


Val His Pro Gln Ala Ala Leu Leu Val Leu Thr Val Val Ile Glu Lys 
                565                 570                 575


Arg Glu His Ser Pro Ser Trp Thr Phe Glu His Leu Val Tyr Gln Val 
            580                 585                 590


Glu Val Ser Glu Ser Leu Ser Pro Met Thr Gln Met Leu Gln Thr Gln 
        595                 600                 605


Ala His Pro Leu Gly Pro Gln Arg Ala Ala Ser Pro Leu Arg Tyr Ser 
    610                 615                 620


Leu Glu Pro Ser Val Asp Ser Ala Met Phe Gly Ile Arg Pro Tyr Thr 
625                 630                 635                 640


Gly Trp Ile Tyr Leu Arg Arg Gln Phe Asp Tyr Glu Ser Thr Gln Thr 
                645                 650                 655


Tyr Asn Phe Arg Val Phe Ala Trp Ile Pro Glu Asp Gly Phe Leu Gln 
            660                 665                 670


Asn Val Ser Thr Thr Val Ile Val Arg Val Trp Asp Glu Asn Asp Asn 
        675                 680                 685


Ser Pro Thr Phe Leu His Asp Val Leu Phe Leu Lys Val Glu Glu Ser 
    690                 695                 700


Pro Val Pro Gln Gly Val Ile Gly Lys Ile Thr Ala Ile Asp Met Asp 
705                 710                 715                 720


Ser Gly Lys Asn Gly Gln Leu Leu Tyr Phe Leu Leu Ser Asp Gly Lys 
                725                 730                 735


Phe Phe Lys Met Asn Pro Asn Thr Gly Pro Ala Gly Thr Ile Tyr Val 
            740                 745                 750


Ile Thr Trp Ala Asp Gly Ala Ala Ala Phe Ser Gly Thr Asp Phe Ala 
        755                 760                 765


Phe Ser Ser Asp Glu Leu Gln Ala Phe Val Leu Lys Ser Leu Phe Cys 
    770                 775                 780


Glu Leu Gly Glu Gly Glu Leu Ile Asn Trp Val Ala Leu Asp Arg Glu 
785                 790                 795                 800


His Arg Gly His His Glu Met Thr Val Leu Val Thr Asp Arg Gly Ser 
                805                 810                 815


Pro Pro Arg Asn Ala Thr Met Ala Val Tyr Val Ser Val Thr Asp Ile 
            820                 825                 830


Asn Asp Asn Arg Pro Phe Phe Pro Gln Cys Leu Pro Gly Lys Glu Leu 
        835                 840                 845


His Val Lys Val Leu Glu Gly Gln Pro Val Asn Met Leu Val Thr Thr 
    850                 855                 860


Val Phe Ala Lys Asp Pro Asp Glu Gly Asn Asn Ala Glu Val Thr Tyr 
865                 870                 875                 880


Ser Val Ser Ser Glu Asp Ser Ser Asp His Phe Lys Ile Asp Ala Asn 
                885                 890                 895


Asn Gly Glu Ile Arg Thr Thr Thr Ile Leu Ser Tyr Asp Tyr Arg Pro 
            900                 905                 910


Ser Tyr Arg Met Ser Val Ile Ala Thr Asp Gln Gly Val Pro Pro Leu 
        915                 920                 925


Gln Gly Gln Ala Val Val Asn Ile Gln Val Ile Pro Leu Ser Lys Gly 
    930                 935                 940


Arg Ala Ile Met Ser Gln Asn Ile Arg His Leu Ile Ile Pro Glu Asn 
945                 950                 955                 960


Leu Lys Pro Thr Lys Ile Met Ser Leu Ile Lys Ser Ser Asp His Leu 
                965                 970                 975


Gln Gln His Tyr Asn Gly Lys Leu His Phe Ser Ile Val Ala Asp Asp 
            980                 985                 990


Lys Asp Gly His Phe Glu Ile Asp Ser Ser Thr Gly Asp Leu Phe Leu 
        995                 1000                1005


Ser Lys Glu Leu Asp Tyr Glu Thr Thr Ser His Tyr Leu Phe Arg Val 
    1010                1015                1020


Ile Thr Thr Asp His Ser Lys Asn Leu Ser Leu Ser Ser Thr Val Phe 
1025                1030                1035                1040


Leu Ser Ile Asp Val Glu Asp Gln Asn Asp His Ser Pro Ser Phe Gln 
                1045                1050                1055


Asp Glu Leu Ile Val Ile Ser Val Glu Glu Asn Val Pro Ile Gly Thr 
            1060                1065                1070


Leu Val Tyr Val Phe Asn Ala Lys Asp Asp Asp Gly Ser Phe Leu Asn 
        1075                1080                1085


Ser Arg Ile Gln Tyr Tyr Ile Glu Ser His Asn Pro Gly Thr Asn Pro 
    1090                1095                1100


Phe Leu Ile His Pro Ser Phe Gly Thr Leu Val Thr Val Ser Arg Leu 
1105                1110                1115                1120


Asp Arg Glu Ser Ile Pro Thr Val Ile Leu Thr Val Thr Ala Ser Asp 
                1125                1130                1135


Gln Ala Val Asn Val Thr Asp Arg Arg Leu Arg Ser Leu Thr Ala Gln 
            1140                1145                1150


Ile Val Ile Leu Asp Val Asn Asp His Asn Pro Thr Phe Ile Ser Phe 
        1155                1160                1165


Pro Asn Ala His Val Lys Glu Asp Val Thr Val Gly Ser Leu Val His 
    1170                1175                1180


His Ile Thr Ala His Asp Pro Asp Glu Gly Arg Asn Gly Lys Val Thr 
1185                1190                1195                1200


Tyr Ser Ile Leu Ser Gly Asn Glu Asn Met Thr Phe Met Leu Asp Glu 
                1205                1210                1215


Ser Ser Gly Leu Leu Thr Thr Thr Cys Pro Leu Asp Tyr Glu Met Lys 
            1220                1225                1230


Thr Gln His Ile Leu Thr Val Leu Ala Leu Asp Asp Gly Thr Pro Ala 
        1235                1240                1245


Leu Ser Ser Ser Gln Thr Leu Thr Val Thr Val Leu Asp Val Asn Asp 
    1250                1255                1260


Glu Ala Pro Val Phe Lys Gln His Leu Tyr Glu Ala Ser Val Lys Glu 
1265                1270                1275                1280


Asn Gln Asn Pro Gly Glu Phe Val Thr Arg Val Glu Ala Leu Asp Arg 
                1285                1290                1295


Asp Ser Gly Val Asn Ser Lys Leu Gln Phe Glu Ile Met Pro Gly Ala 
            1300                1305                1310


Ser Phe Glu Leu Phe Glu Ile Asn Ser Asp Thr Gly Glu Val Val Thr 
        1315                1320                1325


Thr Thr Ile Leu Asp Arg Glu Ile Gln Glu Val Phe Thr Leu Arg Val 
    1330                1335                1340


Leu Val Arg Asp Gly Gly Phe Pro Ser Leu Ser Ser Thr Thr Thr Ile 
1345                1350                1355                1360


Leu Cys Thr Val Glu Asp Glu Asn Asp His Ala Pro Glu Phe Ile Val 
                1365                1370                1375


Ser Ser Tyr Asp Ile Glu Val Leu Glu Asn Gln Glu Pro Glu Val Val 
            1380                1385                1390


Tyr Thr Val Leu Ala Ser Asp Met Asp Ala Gly Asn Asn Arg Ala Val 
        1395                1400                1405


Glu Tyr His Ile Ile Asp Gly Asn Thr Asp Glu Cys Phe Thr Ile Asn 
    1410                1415                1420


Glu Met Ser Gly Glu Leu Ser Thr Thr Arg Ala Leu Asp Arg Glu Gln 
1425                1430                1435                1440


Ile Ser Asn Phe Thr Leu Val Ile Leu Cys Ser Asp Leu Gly Asp Pro 
                1445                1450                1455


Pro Arg Ser Ser Val Ile His Leu Gln Val Arg Val Leu Asp Ala Asn 
            1460                1465                1470


Asp His Ser Pro Ser Phe Pro Thr Leu Tyr Tyr Gln Ser Ser Val Arg 
        1475                1480                1485


Glu Asp Ala Glu Val Gly Thr Val Val Leu Val Leu Ser Ala Val Asp 
    1490                1495                1500


Lys Asp Glu Gly Leu Asn Gly Gln Thr Glu Tyr Phe Leu Thr Asp Glu 
1505                1510                1515                1520


Ala Ser Gly Ala Phe Thr Ile Asp Pro Met Ser Gly Thr Leu Lys Thr 
                1525                1530                1535


Ser Asn Thr Leu Asp Arg Glu Ala Arg Ser Gln His Thr Phe Ser Ala 
            1540                1545                1550


Val Ala Arg Asp Cys Ser Ile Gln Gly Ser Arg Ser Thr Thr Val Ile 
        1555                1560                1565


Ile Lys Val Tyr Val Thr Asp Val Asn Asp Asn Asp Pro Val Leu Glu 
    1570                1575                1580


Gln Asn Pro Phe Asp Val Phe Leu Ser Pro Glu Ser Pro Thr Asn Gln 
1585                1590                1595                1600


Thr Thr Val Ile Val Arg Ala Asp Asp Leu Asp Leu Gly Pro Asn Gly 
                1605                1610                1615


Thr Val Val Phe Ser Phe Ala Glu Thr Gln Ser Met Phe Ser Ile Asp 
            1620                1625                1630


Lys Tyr Thr Gly Glu Ile Gln Phe Gln Gln Asn Pro Ser Ser Glu Tyr 
        1635                1640                1645


Phe Pro Ile Trp Leu Gln Leu Lys Val Thr Asp Gln Gly Ile Pro Ala 
    1650                1655                1660


Arg Thr Thr Thr Gly Leu Leu Val Ile His Met Glu Gly Glu Asp Val 
1665                1670                1675                1680


Lys Ile Ser Phe Ser His His Leu Tyr Lys Gly Leu Val Thr Glu Asn 
                1685                1690                1695


Cys Glu Ala Gly Thr Ser Ile Val Thr Val Lys Ala Phe Ala Pro Asp 
            1700                1705                1710


Ser Ile Gln Asp Ser Met Lys Tyr Ser Ile Phe Ser Gly Asn Glu Asp 
        1715                1720                1725


Gly Val Leu Ser Leu Cys Ser Lys Ser Gly Gln Leu Thr Val Lys Glu 
    1730                1735                1740


Pro Lys Phe Leu Asp Phe Glu Val Arg Asn Glu Val Gln Leu Ile Val 
1745                1750                1755                1760


Leu Ala Glu Ser Ser Gly His Arg Ala Tyr Cys Lys Val Ala Val Leu 
                1765                1770                1775


Ile Gln Asp Glu Asn Asp Asn Ser Pro Cys Phe Glu Gln Ser Ile Tyr 
            1780                1785                1790


Gln Ala Ser Val Ser Glu Ser Gln Leu Tyr Asn Ala His Val Ile Gln 
        1795                1800                1805


Val Phe Ala Thr Asp Leu Asp Ser Gly Leu Asn Gly Leu Ile Glu Tyr 
    1810                1815                1820


Ser Ile Leu Ser Gly Asn Gln Glu Glu Ala Phe Gln Ile Asp Ala Leu 
1825                1830                1835                1840


Ser Gly Val Ile Thr Thr Lys Ala Ile Leu Asp Tyr Glu Leu Thr Ser 
                1845                1850                1855


Ser Tyr Ser Leu Ile Val Gln Ala Thr Asp Lys Gly Met Pro Arg Leu 
            1860                1865                1870


Ser Asn Thr Thr Val Ile Lys Val Gln Val Thr Asp Ile Asn Asp Asn 
        1875                1880                1885


Ala Pro Ala Phe Leu Pro Ser Glu Ala Val Glu Ile Thr Glu Asp Ser 
    1890                1895                1900


Leu Pro Gly Val Ile Val Thr His Val Ser Val His Asp Val Asp Leu 
1905                1910                1915                1920


Asn Ser Ala Phe Ile Phe Ser Phe Ala Lys Glu Ser Asn Pro Gly Thr 
                1925                1930                1935


Lys Phe Ala Ile Asp Gln Asn Thr Gly Val Val Val Leu Val Lys Thr 
            1940                1945                1950


Leu Asp Phe Glu Glu Met Thr Glu Tyr Glu Leu Leu Ile Gln Ile Ser 
        1955                1960                1965


Asp Ser Val His Tyr Thr Glu Gly Ala Leu Val Val Arg Val Leu Asp 
    1970                1975                1980


Val Asn Asp Asn Pro Pro Val Phe Ser Gln Asp Phe Tyr Gln Val Thr 
1985                1990                1995                2000


Val Pro Glu Ser Ile Pro Val Gly Tyr Ser Val Leu Thr Leu Ser Ala 
                2005                2010                2015


Thr Asp Leu Glu Ser Asn Glu Asn Ile Ser Tyr Arg Ile Leu Ser Ser 
            2020                2025                2030


Ser Lys Glu Phe Ser Ile Asp Pro Lys Asn Gly Thr Ile Phe Thr Ile 
        2035                2040                2045


Ser Pro Val Leu Leu Leu Asp Thr Ile Ser Thr Thr Gln Phe Leu Val 
    2050                2055                2060


Glu Ala Ser Asp Gly Gly Asn Pro Asp Leu Arg Ala Leu Thr Leu Val 
2065                2070                2075                2080


Glu Ile Gly Ile Glu Asp Met Asn Asn Tyr Ala Pro Glu Phe Thr Val 
                2085                2090                2095


Lys Ser Tyr Asn Leu Ser Leu Ser Glu Asp Ala Leu Val Gly Ser Thr 
            2100                2105                2110


Leu Val Thr Phe Ser Asn Ile Asp His Asp Trp Thr Arg Glu Asn Thr 
        2115                2120                2125


Tyr Val Glu Tyr Ser Ile Ile Ser Gly Asn Ser Gln Asn Asn Phe His 
    2130                2135                2140


Val Glu Thr Lys Phe Phe His Ser Glu Tyr Pro Tyr Lys Gln Val Gly 
2145                2150                2155                2160


Tyr Leu Val Leu Leu His Ser Leu Asp Arg Glu Ala Ser Ala Ser His 
                2165                2170                2175


Glu Leu Val Ile Leu Ala Ser Asp Ser Gly Cys Pro Pro Leu Ser Ser 
            2180                2185                2190


Thr Ala Val Ile Ser Ile Gln Val Leu Asp Val Asn Asp Asn Pro Pro 
        2195                2200                2205


Asn Phe Ser Ser Leu Ser Tyr His Thr His Val Lys Glu Ser Thr Pro 
    2210                2215                2220


Leu Gly Ser His Ile Thr Val Val Ser Ala Asn Asp Arg Asp Thr Gly 
2225                2230                2235                2240


Ser His Ala Glu Ile Ile Tyr Asn Ile Ile Ser Gly Asn Glu Lys Gly 
                2245                2250                2255


His Phe Tyr Leu Glu Glu Asn Thr Gly Val Leu Tyr Leu Ile Lys Pro 
            2260                2265                2270


Leu Asp Tyr Glu Lys Met Thr Lys Phe Thr Leu Thr Val Gln Ala Ser 
        2275                2280                2285


Asp Ala Glu Lys Lys His Phe Ser Phe Ala Val Val Phe Val Ser Val 
    2290                2295                2300


Leu Asp Asp Asn Asp His Ala Pro Gln Phe Met Phe Ser Ser Phe Ser 
2305                2310                2315                2320


Cys Ile Val Pro Glu Asn Leu Pro Ile Ser Ser Thr Ile Cys Ser Ile 
                2325                2330                2335


Asn Ala Leu Asp Phe Asp Ala Gly Pro Tyr Gly Glu Leu Thr Tyr Ser 
            2340                2345                2350


Ile Val Ser Pro Cys Phe Leu Thr His Gly Met Ser Tyr Asp His Asp 
        2355                2360                2365


Leu Phe Leu Ile Asp Pro Leu Thr Gly Asp Ile His Ala Lys Gln Ile 
    2370                2375                2380


Leu Asp Tyr Glu Asn Gly Asn Lys Tyr Cys Leu Thr Val Gln Ala Lys 
2385                2390                2395                2400


Asp Lys Gly Asp Ala Thr Ala Ser Leu Val Val Trp Val Asp Ile Glu 
                2405                2410                2415


Gly Ile Asp Glu Phe Glu Pro Ile Phe Thr Gln Asp Gln Tyr Phe Phe 
            2420                2425                2430


Thr Leu Pro Glu Lys Asn Lys Asp Arg Gln Leu Ile Gly Arg Val Glu 
        2435                2440                2445


Ala Ser Asp Ala Asp Ala Gly Ile Asp Gly Val Ile Leu Tyr Ser Leu 
    2450                2455                2460


Gly Thr Ser Ser Pro Phe Phe Ser Val Asn Lys Thr Asn Gly Asn Ile 
2465                2470                2475                2480


Tyr Leu Ile Arg Ala Leu Pro Leu Ile Lys Ser Gln Leu Asn Lys Glu 
                2485                2490                2495


Asp Thr Leu Glu Met Lys Ile Ile Ala His Ser Pro Lys Ser Asp Ser 
            2500                2505                2510


Lys Phe Ala Ser Cys Thr Val Phe Val Asn Val Ser Phe Ser Ser Glu 
        2515                2520                2525


Gly Thr Pro Leu Ala Val Phe Ala Ser Ser Phe Ser Ile Ser Leu Val 
    2530                2535                2540


Val Ser Phe Leu Val Phe Leu Ile Leu Ile Cys Ile Leu Ile Val Met 
2545                2550                2555                2560


Ile Leu Arg His Lys Gln Lys Asp Thr Ile Asn Asn Tyr Glu Glu Lys 
                2565                2570                2575


Lys Thr Ser Ser Leu Asp Ala Asp Leu Arg Val Thr Arg Asp Ala Ser 
            2580                2585                2590


Val Leu Lys Ala Phe Gln Lys Thr Asp Asp Cys Ser Asn Glu Val Val 
        2595                2600                2605


Pro Val Asp Ala Thr Pro Glu Trp Leu Ser Leu Ile Ser Ile Met Glu 
    2610                2615                2620


Lys Asp Ile Val Asn Leu Tyr Arg His Ser Asn Ser Ser Gly His Cys 
2625                2630                2635                2640


Ser Val Glu Gly Glu Thr Ala Glu Asp Lys Glu Ile Gln Arg Ile Asn 
                2645                2650                2655


Glu His Pro Tyr Arg Lys Cys Ser Asp Ser Ala Leu Ser Asp His Glu 
            2660                2665                2670


Ser Arg Val Pro Asp Ser Gly Ile Pro Arg Asp Ser Asp Gln Leu Ser 
        2675                2680                2685


Cys Leu Ser Gly Glu Thr Asp Val Met Val Thr Ala Glu Thr Ala Glu 
    2690                2695                2700


Ala Ser Gln Thr Phe Gly Glu Gly Asp Gln Gly Glu Gly Cys Ser Thr 
2705                2710                2715                2720


Thr Cys Ala Gln Asn Asn Val Leu Pro Gln Thr Val Gln Lys Arg Glu 
                2725                2730                2735


Ala Lys Glu Ser Ile Leu Ala Asp Val Arg Lys Glu Ser Val Phe Ile 
            2740                2745                2750


Ser Gly Asp Gln Glu Val Arg Cys Ala Ala Leu Ser Thr Gln Thr Thr 
        2755                2760                2765


Ser Asp His Asp Gly Lys Asp Asn Tyr His Trp Asn Tyr Leu Leu Ser 
    2770                2775                2780


Trp Glu Pro Lys Phe Gln Pro Leu Ala Ser Val Phe Asn Asp Ile Ala 
2785                2790                2795                2800


Lys Leu Lys Asp Glu His Leu His Met Pro Gly Ile Pro Lys Glu Lys 
                2805                2810                2815


Lys Ser Phe Val Phe Pro Pro Pro Leu Ile Thr Ala Val Ala Gln Pro 
            2820                2825                2830


Gly Ile Lys Ala Val Pro Pro Arg Met Pro Ala Val Asn Leu Gly Gln 
        2835                2840                2845


Val Pro Pro Lys His Pro Arg Ser Pro Ile Pro Tyr His Leu Gly Ser 
    2850                2855                2860


Leu Pro Glu Gly Met Thr Pro Asn Phe Ser Pro Ser Leu Ser Leu Leu 
2865                2870                2875                2880


Thr Met Gln Pro Pro Ala Leu Ser Pro Leu Leu Arg Glu Gly Glu Leu 
                2885                2890                2895


Leu Gly Thr His Ile Ser Gly Thr Cys His Glu Leu Lys Ala Glu Asp 
            2900                2905                2910


Glu Val Gln Ile 
        2915


<210>  2596
<211>  4490
<212>  DNA
<213>  Homo sapiens

<400>  2596
agatccccat cctctccttg tgtgtgcgcg cttcatataa tctcctcctt tttggcaaaa     60

gaaataatgc acctgacttt accagggggg aacaaccagc cgagtagaac aaggaacaga    120

tgtaaaggga ataaaaggag agagaaaaag agatgagatt cgtttaaaga aatccagggg    180

cagaagaggt ggctgccgcg gcagaggcag ctagagctta cttccctgtc tgcgtgagct    240

gcaggcagag gacgctttca ccagttgcag atgtaacctc gggaattcct gggccgtcgg    300

tttgtttgcc aaacaaagtc ttttcttctc tggctcagac actgaagagg ctcctggatt    360

tttctgcgat cctgccacaa gctggcagtt acccgagagc cttcccaagg agctggagga    420

gaaatgagcc cttgtgggcg gaagatgggc gaagggcgtc agcagcggcg ggctccggtc    480

gggaagctcc ttctgctccc cgggaggaga gatacacccc atgggcggtc aggcagcagc    540

ggcgccagga cgcagcgctc cctgctctgg ctcttggtgc acgtgtggct gtgggcggcc    600

tcgggctcct ctgcccagtt gttcaacctc accctttccg tagatgaggg gcttcccccg    660

gacacgctgg taggtgacat ccgcgccggg ctgccggccg cgcagcagca ggaggggagc    720

ggcttctttc tgtcggagga ctccgatgac tccccgctgc tggacgactt ccacgtgcac    780

ccggacaccg gcatcatccg cactgcgcgg cgcctggacc gcgagcggcg ggaccactac    840

agcttcgtcg ccgccacgct gctgggcgct gtggtgcagg tggagattcg cgtcaacgac    900

gtgaatgacc actcgccccg ctttcccctc gactccctgc aactcgacgt ctccgagctc    960

agcccgccag ggaccgcctt ccgcctgcca gttgcccacg atccggacgc cggactgttc   1020

agcactcagg gctacaccct ggtgcaaccg tccgacctgc ccaaggaccc cgcaggcccg   1080

ttcttccagt tgcgctaccg gactccgggg ccactaccgt caccgctttt gccaggctcc   1140

tcgtcacccc tggagcctct agatctggtg ctgctgcggc gcttggaccg agaggaggcg   1200

gcggcgcacc ggctgcagat cgaggcatgg gacggcggcc gaccccggcg caccggcctc   1260

ctgagcgtgg agctgcgcgt gctggatgag aacgacaacc cgccggtctt tgagcaggac   1320

gagtaccgcg ccgcggtgcg cgaggacgcc cagccgggcg ccgaggtctg tcgcgtgcgc   1380

gccaccgacc gcgacctggg gcccaatggc ttcgtgcgct acagcgtccg cgcccggcaa   1440

gtgcctgggg cgggtagcgg cggcggggca ctgggcgacg cggcctactt cgcggtggag   1500

gagctgagcg gcgtggtgcg agtgtggaga cctctggacc gcgaggcaca ggcctggcac   1560

cagttggtgg tggaggcccg cgatggaggc gccgagcctg aggttgccac ggtgcgcgtg   1620

tccatcgccg tgctggacgt gaatgacaac cggccagcaa ttcacgtgct ctttctcaca   1680

gagggaggcg tcgcccgtgt ctctgaaggc gcccgaccgg gcgactacgt ggctcgcgtc   1740

tcggtgtctg acgcggacgg tgactgggag aaggaagatg aggccacagg ggagcttggt   1800

gtgggtcttg gagacgggag catctctctg tccttggaag gcggagaggg agacttcgcg   1860

ttgctacccg gcggcccccc aggggtattt ttcctttgcg tggaggggcc cctggacaga   1920

gagagccgcg atctgtatga gttactactg gtggccacgg acgcggggtc cccgccgctg   1980

agcacggagg agacgctgct actccgggtc gctgacctca atgaccaacc acctctcttc   2040

agccaacagc attacaaggc ctcagtgtcc gaggccgcgg cccctggcac tgtagtcatg   2100

tgggtcagcg cctccgatgc cgacgaggca ggcagtgatc acgcctggct gcgctacact   2160

gtagtccaac tctcggctcc ctgcaatctc ggctccctgc aatcaaagat ggtccacacc   2220

gcagagtgtg gaccatcttt tgccattgat tccgaaagcg gtgcgatcag cactatccgg   2280

actctagacc gagaggtcca ggaggcggtg gagctgaaag tggtggccca ggacctcgga   2340

gagcccccac tctctgccac ctgcctggtg agcatcaccg tagatgatgt gaatgacaat   2400

gagcccatct tctggaggca ggtgtacaat gccaccattg cagagcatgc cccggttgga   2460

cactgctttc tgcaggtgac agcctctgat gcagattcag gactctatgg ctttattgaa   2520

tattctcttt atgatggatt cctgagctat gaagcacctc aggcattccg gatcgaccct   2580

catgatgggc aaatctgtgt ttctcaagat atcgacaggg aaagggatcc agctacctat   2640

gatctcctgg tggaagctaa ggatgggggt gggctaagtg cccaagcctt tgttcgtgtg   2700

gacctggagg acgtgaatga taatcatcct gtgtttaacc catcaaccta tgtgacgagc   2760

atcagtgatg agacccagcc aggcaccgag atcatcaatg ttcttgccac tgaccaggac   2820

tctgggatat atgggacagt ggcttatgag cttattccag gaaacgtgtc gtcccttttt   2880

accattgact ccaccacagg aattatttac ttaacattac ctcttagtca tttggaatct   2940

accacacttt cgttgatggt ctctgctcaa gacggtggtg ggctcacagc tgtcattaat   3000

gccgatgtca ccatacacat tttccagaca actctggcac ctgctgagtt tgaaaggcct   3060

aagtacactt tcttagttta tgaagatgtg cctgaagata gtcccattgg aacagtgaaa   3120

gcaagagagc ccttgaactc ctcagaacca atcttttaca ggatttcttc tggtgatctc   3180

ggcggaaagt tctccattca cccgcggctg ggcactattc gcacccggaa gcccctggat   3240

cacgagacgc agcccgtggt tgtgctcacg gtgcaggcgc agctcggcag cgccccagcc   3300

tgcagcagca ccgaggtcaa cataacagtc atggatgtca atgacaacca cccagcgttc   3360

ctcaggacct cggatgagat tagaatatcc cagaccacgc cccctggcac agccttgtac   3420

ctcgcacgtg cggaagacag agacagtggg cggaacggac tcatccggta ctccatcgcc   3480

agcccgcagc caggcgtctt tgccatcgac agagccctgg gggtgctgtt cctcaacggc   3540

agcctgggcg cgggcgagca gcgggagctc acgctgactc tcagggccga ggaccaaggc   3600

gtgcatcctc aggcagccct gctggtgctg acagtcgtta tcgagaaacg cgaacacagc   3660

ccatcctgga ctttcgaaca tttggtctat caagtggaag tcagtgagtc tctctcaccg   3720

atgacacaaa tgctgcaaac acaggcgcac ccacttggcc cccagcgtgc agcctcgcct   3780

cttaggtact cgctggaacc cagcgtagac tctgctatgt ttggaatccg cccttacacg   3840

ggctggattt atttgcggcg acagtttgac tatgaatcca cccaaacata taattttaga   3900

gtgtttgctt ggatccccga ggacggattc ttgcaaaatg tgagcactac agtcattgtt   3960

cgtgtctggg atgagaatga caattccccc accttcttgc atgatgtgtt gtttttgaaa   4020

gtcgaagaga gccctgttcc ccaaggggta ataggcaaaa ttacagctat tgacatggac   4080

tctggaaaga atggacagct attatatttc cttttgtctg atggaaaatt cttcaagatg   4140

aatcctaata caggagagtt aatcaattgg gtggcactgg atcgtgagca ccgggggcac   4200

catgagatga ctgtgctagt gacagaccgc ggctccccac cacgaaacgc caccatggcg   4260

gtttacgtct cagttactga catcaatgat aacaggccct tcttccccca gtgtctccct   4320

ggaaaggagt tacacgtgaa ggttctggaa ggtcaaccag taaatatgtt ggttacaact   4380

gtgtttgcaa aggatcctga tgaaggaaat aatgcagaag ttacatactc agtatcttca   4440

gctagaccta tgcctctgaa gggaaaaaca gcatttggga agcagtcgtg              4490


<210>  2597
<211>  1354
<212>  PRT
<213>  Homo sapiens

<400>  2597

Met Ser Pro Cys Gly Arg Lys Met Gly Glu Gly Arg Gln Gln Arg Arg 
1               5                   10                  15


Ala Pro Val Gly Lys Leu Leu Leu Leu Pro Gly Arg Arg Asp Thr Pro 
            20                  25                  30


His Gly Arg Ser Gly Ser Ser Gly Ala Arg Thr Gln Arg Ser Leu Leu 
        35                  40                  45


Trp Leu Leu Val His Val Trp Leu Trp Ala Ala Ser Gly Ser Ser Ala 
    50                  55                  60


Gln Leu Phe Asn Leu Thr Leu Ser Val Asp Glu Gly Leu Pro Pro Asp 
65                  70                  75                  80


Thr Leu Val Gly Asp Ile Arg Ala Gly Leu Pro Ala Ala Gln Gln Gln 
                85                  90                  95


Glu Gly Ser Gly Phe Phe Leu Ser Glu Asp Ser Asp Asp Ser Pro Leu 
            100                 105                 110


Leu Asp Asp Phe His Val His Pro Asp Thr Gly Ile Ile Arg Thr Ala 
        115                 120                 125


Arg Arg Leu Asp Arg Glu Arg Arg Asp His Tyr Ser Phe Val Ala Ala 
    130                 135                 140


Thr Leu Leu Gly Ala Val Val Gln Val Glu Ile Arg Val Asn Asp Val 
145                 150                 155                 160


Asn Asp His Ser Pro Arg Phe Pro Leu Asp Ser Leu Gln Leu Asp Val 
                165                 170                 175


Ser Glu Leu Ser Pro Pro Gly Thr Ala Phe Arg Leu Pro Val Ala His 
            180                 185                 190


Asp Pro Asp Ala Gly Leu Phe Ser Thr Gln Gly Tyr Thr Leu Val Gln 
        195                 200                 205


Pro Ser Asp Leu Pro Lys Asp Pro Ala Gly Pro Phe Phe Gln Leu Arg 
    210                 215                 220


Tyr Arg Thr Pro Gly Pro Leu Pro Ser Pro Leu Leu Pro Gly Ser Ser 
225                 230                 235                 240


Ser Pro Leu Glu Pro Leu Asp Leu Val Leu Leu Arg Arg Leu Asp Arg 
                245                 250                 255


Glu Glu Ala Ala Ala His Arg Leu Gln Ile Glu Ala Trp Asp Gly Gly 
            260                 265                 270


Arg Pro Arg Arg Thr Gly Leu Leu Ser Val Glu Leu Arg Val Leu Asp 
        275                 280                 285


Glu Asn Asp Asn Pro Pro Val Phe Glu Gln Asp Glu Tyr Arg Ala Ala 
    290                 295                 300


Val Arg Glu Asp Ala Gln Pro Gly Ala Glu Val Cys Arg Val Arg Ala 
305                 310                 315                 320


Thr Asp Arg Asp Leu Gly Pro Asn Gly Phe Val Arg Tyr Ser Val Arg 
                325                 330                 335


Ala Arg Gln Val Pro Gly Ala Gly Ser Gly Gly Gly Ala Leu Gly Asp 
            340                 345                 350


Ala Ala Tyr Phe Ala Val Glu Glu Leu Ser Gly Val Val Arg Val Trp 
        355                 360                 365


Arg Pro Leu Asp Arg Glu Ala Gln Ala Trp His Gln Leu Val Val Glu 
    370                 375                 380


Ala Arg Asp Gly Gly Ala Glu Pro Glu Val Ala Thr Val Arg Val Ser 
385                 390                 395                 400


Ile Ala Val Leu Asp Val Asn Asp Asn Arg Pro Ala Ile His Val Leu 
                405                 410                 415


Phe Leu Thr Glu Gly Gly Val Ala Arg Val Ser Glu Gly Ala Arg Pro 
            420                 425                 430


Gly Asp Tyr Val Ala Arg Val Ser Val Ser Asp Ala Asp Gly Asp Trp 
        435                 440                 445


Glu Lys Glu Asp Glu Ala Thr Gly Glu Leu Gly Val Gly Leu Gly Asp 
    450                 455                 460


Gly Ser Ile Ser Leu Ser Leu Glu Gly Gly Glu Gly Asp Phe Ala Leu 
465                 470                 475                 480


Leu Pro Gly Gly Pro Pro Gly Val Phe Phe Leu Cys Val Glu Gly Pro 
                485                 490                 495


Leu Asp Arg Glu Ser Arg Asp Leu Tyr Glu Leu Leu Leu Val Ala Thr 
            500                 505                 510


Asp Ala Gly Ser Pro Pro Leu Ser Thr Glu Glu Thr Leu Leu Leu Arg 
        515                 520                 525


Val Ala Asp Leu Asn Asp Gln Pro Pro Leu Phe Ser Gln Gln His Tyr 
    530                 535                 540


Lys Ala Ser Val Ser Glu Ala Ala Ala Pro Gly Thr Val Val Met Trp 
545                 550                 555                 560


Val Ser Ala Ser Asp Ala Asp Glu Ala Gly Ser Asp His Ala Trp Leu 
                565                 570                 575


Arg Tyr Thr Val Val Gln Leu Ser Ala Pro Cys Asn Leu Gly Ser Leu 
            580                 585                 590


Gln Ser Lys Met Val His Thr Ala Glu Cys Gly Pro Ser Phe Ala Ile 
        595                 600                 605


Asp Ser Glu Ser Gly Ala Ile Ser Thr Ile Arg Thr Leu Asp Arg Glu 
    610                 615                 620


Val Gln Glu Ala Val Glu Leu Lys Val Val Ala Gln Asp Leu Gly Glu 
625                 630                 635                 640


Pro Pro Leu Ser Ala Thr Cys Leu Val Ser Ile Thr Val Asp Asp Val 
                645                 650                 655


Asn Asp Asn Glu Pro Ile Phe Trp Arg Gln Val Tyr Asn Ala Thr Ile 
            660                 665                 670


Ala Glu His Ala Pro Val Gly His Cys Phe Leu Gln Val Thr Ala Ser 
        675                 680                 685


Asp Ala Asp Ser Gly Leu Tyr Gly Phe Ile Glu Tyr Ser Leu Tyr Asp 
    690                 695                 700


Gly Phe Leu Ser Tyr Glu Ala Pro Gln Ala Phe Arg Ile Asp Pro His 
705                 710                 715                 720


Asp Gly Gln Ile Cys Val Ser Gln Asp Ile Asp Arg Glu Arg Asp Pro 
                725                 730                 735


Ala Thr Tyr Asp Leu Leu Val Glu Ala Lys Asp Gly Gly Gly Leu Ser 
            740                 745                 750


Ala Gln Ala Phe Val Arg Val Asp Leu Glu Asp Val Asn Asp Asn His 
        755                 760                 765


Pro Val Phe Asn Pro Ser Thr Tyr Val Thr Ser Ile Ser Asp Glu Thr 
    770                 775                 780


Gln Pro Gly Thr Glu Ile Ile Asn Val Leu Ala Thr Asp Gln Asp Ser 
785                 790                 795                 800


Gly Ile Tyr Gly Thr Val Ala Tyr Glu Leu Ile Pro Gly Asn Val Ser 
                805                 810                 815


Ser Leu Phe Thr Ile Asp Ser Thr Thr Gly Ile Ile Tyr Leu Thr Leu 
            820                 825                 830


Pro Leu Ser His Leu Glu Ser Thr Thr Leu Ser Leu Met Val Ser Ala 
        835                 840                 845


Gln Asp Gly Gly Gly Leu Thr Ala Val Ile Asn Ala Asp Val Thr Ile 
    850                 855                 860


His Ile Phe Gln Thr Thr Leu Ala Pro Ala Glu Phe Glu Arg Pro Lys 
865                 870                 875                 880


Tyr Thr Phe Leu Val Tyr Glu Asp Val Pro Glu Asp Ser Pro Ile Gly 
                885                 890                 895


Thr Val Lys Ala Arg Glu Pro Leu Asn Ser Ser Glu Pro Ile Phe Tyr 
            900                 905                 910


Arg Ile Ser Ser Gly Asp Leu Gly Gly Lys Phe Ser Ile His Pro Arg 
        915                 920                 925


Leu Gly Thr Ile Arg Thr Arg Lys Pro Leu Asp His Glu Thr Gln Pro 
    930                 935                 940


Val Val Val Leu Thr Val Gln Ala Gln Leu Gly Ser Ala Pro Ala Cys 
945                 950                 955                 960


Ser Ser Thr Glu Val Asn Ile Thr Val Met Asp Val Asn Asp Asn His 
                965                 970                 975


Pro Ala Phe Leu Arg Thr Ser Asp Glu Ile Arg Ile Ser Gln Thr Thr 
            980                 985                 990


Pro Pro Gly Thr Ala Leu Tyr Leu Ala Arg Ala Glu Asp Arg Asp Ser 
        995                 1000                1005


Gly Arg Asn Gly Leu Ile Arg Tyr Ser Ile Ala Ser Pro Gln Pro Gly 
    1010                1015                1020


Val Phe Ala Ile Asp Arg Ala Leu Gly Val Leu Phe Leu Asn Gly Ser 
1025                1030                1035                1040


Leu Gly Ala Gly Glu Gln Arg Glu Leu Thr Leu Thr Leu Arg Ala Glu 
                1045                1050                1055


Asp Gln Gly Val His Pro Gln Ala Ala Leu Leu Val Leu Thr Val Val 
            1060                1065                1070


Ile Glu Lys Arg Glu His Ser Pro Ser Trp Thr Phe Glu His Leu Val 
        1075                1080                1085


Tyr Gln Val Glu Val Ser Glu Ser Leu Ser Pro Met Thr Gln Met Leu 
    1090                1095                1100


Gln Thr Gln Ala His Pro Leu Gly Pro Gln Arg Ala Ala Ser Pro Leu 
1105                1110                1115                1120


Arg Tyr Ser Leu Glu Pro Ser Val Asp Ser Ala Met Phe Gly Ile Arg 
                1125                1130                1135


Pro Tyr Thr Gly Trp Ile Tyr Leu Arg Arg Gln Phe Asp Tyr Glu Ser 
            1140                1145                1150


Thr Gln Thr Tyr Asn Phe Arg Val Phe Ala Trp Ile Pro Glu Asp Gly 
        1155                1160                1165


Phe Leu Gln Asn Val Ser Thr Thr Val Ile Val Arg Val Trp Asp Glu 
    1170                1175                1180


Asn Asp Asn Ser Pro Thr Phe Leu His Asp Val Leu Phe Leu Lys Val 
1185                1190                1195                1200


Glu Glu Ser Pro Val Pro Gln Gly Val Ile Gly Lys Ile Thr Ala Ile 
                1205                1210                1215


Asp Met Asp Ser Gly Lys Asn Gly Gln Leu Leu Tyr Phe Leu Leu Ser 
            1220                1225                1230


Asp Gly Lys Phe Phe Lys Met Asn Pro Asn Thr Gly Glu Leu Ile Asn 
        1235                1240                1245


Trp Val Ala Leu Asp Arg Glu His Arg Gly His His Glu Met Thr Val 
    1250                1255                1260


Leu Val Thr Asp Arg Gly Ser Pro Pro Arg Asn Ala Thr Met Ala Val 
1265                1270                1275                1280


Tyr Val Ser Val Thr Asp Ile Asn Asp Asn Arg Pro Phe Phe Pro Gln 
                1285                1290                1295


Cys Leu Pro Gly Lys Glu Leu His Val Lys Val Leu Glu Gly Gln Pro 
            1300                1305                1310


Val Asn Met Leu Val Thr Thr Val Phe Ala Lys Asp Pro Asp Glu Gly 
        1315                1320                1325


Asn Asn Ala Glu Val Thr Tyr Ser Val Ser Ser Ala Arg Pro Met Pro 
    1330                1335                1340


Leu Lys Gly Lys Thr Ala Phe Gly Lys Gln 
1345                1350


<210>  2598
<211>  1854
<212>  DNA
<213>  Homo sapiens

<400>  2598
gagagtctgg ctggaggcca aacaacacaa aaccagcaca cttaacaaaa atataaccaa     60

tgacccttgc agagtccact taactcccct ccaccagagc aggtgctggt atccacagct    120

gagagacctg aagatggatc acatcacagg actccttgca gacattctcc agtaccagcc    180

cagagcctgg taggtctgtt gggtggctag accagtattc taagtgaagt aactcggaaa    240

tggaaaacca aacatcatct gttctcactc atcagtagga gctaagctat gagaacacaa    300

agacctgtcc acgctgagtt tatagcaact gtcaattacg gttcagattt tcctacccca    360

gcgtgacttt ccaaagaggc ttctgctcat ggatttctgc tccaggaaga tgcaacagga    420

aggtcctcac aagatggctg aacagatgca ggtgctgtgc ctctggactg cctagcctcc    480

agaactgata catatgcagg atgtgcagct ttgttacaca gtatgaagca tgtctttagg    540

actttctgtg ccatctggta tccatcaagg ggagagtccc aaactgcact ggaaggcatc    600

ttccagatgg tggtgggcgc taaagatcag ctgtgtgggt gtgagcttcc catgcctgtg    660

gagaagcagc aattgaattg ctcatctgga atgaagtttc gtggattttt tttttttttg    720

aacagatcac tgactacttc caatatgcaa taccaagtaa agactgcaaa tgactgtgcc    780

acagggagga aaagcagtca acctgtcttt agggacctgt tcaaatttct ggtgtctcag    840

tggatgttga tttctgacat aaagccattt gtgcacatga ggaagatact gtaggaggca    900

tttgctgtga gccagtgttt ggtctttagc tgaaacagac atttagccat aaaccaccaa    960

ccagaaagat caataagaca cggttcctct tctggtgggc cacataaagg aagttgtcat   1020

gttccaactt aatgtgtggg ttgagaggga tctgcacaaa cgagcgtcat cggggagaaa   1080

aatatatccc agtctgcgtg gtcacgggga gcttcctggg caagcaacat ctagactggt   1140

gtttgaccaa actactgggc accatacccc agccaagtca gcatataatg tgaaccatca   1200

cagtgggaga catgtcacaa agtggtaaga cagcaagaat tggtggtctg ggctggattc   1260

cagagaacct ggactgtgcc tatgaagcac cactgccctg tagacctggg ataataaaca   1320

ctgatgccta aagggaccag gcaggaactc cttcatagat gaatgcttgg tgttattcat   1380

tacccagtct tgagggactc actggtgagc tcggggctca gggagtagac ctgactgggg   1440

agctaagtga tctcgtgtga ctctctatgc ctcgttgcca ccagcgtggg ccatctccag   1500

gggctctcaa accgatagaa gaccttgcgg tgtgggaaaa cagctccaga gcttctaagc   1560

tgagcggatt gttcctagtg aggaaggtct tgtcccatct gttccaagct atttgtccat   1620

gtaaaactgt caacgttcca agccactgac tgacagggta agaagagtga gtctcaagag   1680

agtgaggaac ggtgaatctt tggcagactc tgtgtgtgcc catggaagag acagtgacag   1740

aaattatgta atgaaaaaaa tgtagcacaa gccttatgaa tttttacttt tcactccatg   1800

ggattcccat atcaaaagac ctattctaca caaaataaag ttctctatga agaa         1854


<210>  2599
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  2599

Met Lys His Val Phe Arg Thr Phe Cys Ala Ile Trp Tyr Pro Ser Arg 
1               5                   10                  15


Gly Glu Ser Gln Thr Ala Leu Glu Gly Ile Phe Gln Met Val Val Gly 
            20                  25                  30


Ala Lys Asp Gln Leu Cys Gly Cys Glu Leu Pro Met Pro Val Glu Lys 
        35                  40                  45


Gln Gln Leu Asn Cys Ser Ser Gly Met Lys Phe Arg Gly Phe Phe Phe 
    50                  55                  60


Phe Leu Asn Arg Ser Leu Thr Thr Ser Asn Met Gln Tyr Gln Val Lys 
65                  70                  75                  80


Thr Ala Asn Asp Cys Ala Thr Gly Arg Lys Ser Ser Gln Pro Val Phe 
                85                  90                  95


Arg Asp Leu Phe Lys Phe Leu Val Ser Gln Trp Met Leu Ile Ser Asp 
            100                 105                 110


Ile Lys Pro Phe Val His Met Arg Lys Ile Leu 
        115                 120


<210>  2600
<211>  516
<212>  DNA
<213>  Homo sapiens

<400>  2600
gcagctgcag caagcctcac ccaaggagag tctggctgga ggccaaacaa cacaaaacca     60

gcacacttaa caaaaatata accaatgacc cttgcagagt ccacttaact cccctccacc    120

agagcaggtg ctggtatcca cagctgagag acctgaagat ggatcacatc acaggactcc    180

ttgcagacat tctccagtac cagcccagag cctgacctgt ccacgctgag tttatagcaa    240

ctgtcaatta cggttcagat tttcctaccc cagcgtgact ttccaaagag gcttctgctc    300

atggatttct gctccaggaa gatgcaacag gaaggtcctc acaagatggc tgaacagatg    360

caggtgctgt gcctctggac tgcctagcct ccagaactat gcaataccaa gtaaagactg    420

caaatgactg tgccacaggg aggaaaagca gtcaacctgt ctttagggac ctgttcaaat    480

ttctggtgtc tcagtggatg ttgatttctg acataa                              516


<210>  2601
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  2601

Met Gln Tyr Gln Val Lys Thr Ala Asn Asp Cys Ala Thr Gly Arg Lys 
1               5                   10                  15


Ser Ser Gln Pro Val Phe Arg Asp Leu Phe Lys Phe Leu Val Ser Gln 
            20                  25                  30


Trp Met Leu Ile Ser Asp 
        35


<210>  2602
<211>  2867
<212>  DNA
<213>  Homo sapiens

<400>  2602
atgagcacca atcgcctacg ggaggccaga aaaggctgcg tggtgctccc ctctcagggc     60

ctggccctgt ccacctgggc cttggtgacc cgcagccggg actcttgctg taaagtgacg    120

cagtgctctc cctgggagga caaaagaatc cccggagtag agaaggaggc cagcgagtct    180

cagttcgctg ctcgctcaga gccgcccagg tgcgagggcg tcttcaccag aaatcggtgc    240

tcccgcgcgc cccaccctcc ggggccctgc agatgccggg tcgggggccg ccagcaggcc    300

ctttggctcc tgctggagac actggaagac caggcgacca ggacagcggg tcgggccagt    360

gcgcttgccc agcggcacgt gggcctcaag cctggtcccc agcggctgcg ccagcctagc    420

tgtgttcacc ttggggccgc gagggcctcc caccggctgg cagctggtgg acacgctgtc    480

aagatcgggg gaaaaaaagg aaggaaggag gctaggggga cacagggctg gtggcctccg    540

cagtctttga cctgcgacgg gcgcgagcgc acctccgcgc ctttgcgcag agaccttccc    600

ccaagattgg ctcacgacgc ctcctacccc gaagtcaagg gctccctgtg gcaaatcctc    660

acacgccctc ctcctccccg cccatccccg gcgccaggac tgacggggag agggcaaggc    720

cgggccagag gggctgtggg cctggactgc ggctgtcgcc cgcggccctg ctcttttggg    780

cagccagacg tggggtcagc gcccagtcgc agcctccggg gatgctccct gaggttccgg    840

aacaccccgc cccccatccc aggatctgac caaccctcaa gccacggccg gccccggttc    900

cgcgagacgg gggactctga ggattgtcct cccttccggg ctgggactcc cccacagcag    960

ccgaccgccc ccagttcaga gtggcccggc ccgcagcgct ccccgggcac aggtcccagg   1020

tggacggctc cgctcccgcg cccggctcct ctgcccgcca agcgccccgg ggattccccg   1080

gcctccaagc ggccgcggcc gggtggagtc agccccgaag cccgggatcc cccgaaggga   1140

gaaaacccgc tctgctcctc tgaagcggcg ggagaaaccg gccccaccca ggtccggggg   1200

cccgacgccc tcggcggagg ccggctccag ggccgcctgg tgccggtttc cgccgagctg   1260

gagcgcgcgg gccacggctt ctctggggac gcagaagcga gaagcgggga cctcggcgcg   1320

cgccccgcgt cccgctcttc ctgcccgcgc cccggccccc ggcccgcgcc ccggccgccg   1380

gcatggtgct gctggccggg accgggccgg agggcggcgg ggcgcgctgc atgaccccac   1440

caccgccgtc cccaccccgg ggcgcgcagg tcgaggagga ccccgctgac tacgaagagt   1500

ttgaggactt ctcgagtctg ccagacaccc gcagcatcgc ctcggacgac tctttctacc   1560

ctttcgagga cgaggaggag cacggcgtcg agagcgcgga gagcgtcccg gagggcgtcc   1620

cggaaagcgt cccggagacg gcgaccctcc tgcgcgccgc ctgcgccaac aacgtggggc   1680

tgctgcggac gctggtgcgg cgcggggtga gcgtcgagga ggcgcaggag actgaccgca   1740

acggcaggac cggccttatt gtcgcctgct accacggctt tgtggatacc gtggtggcct   1800

tagcagagtg cccccacgtt gacgtcaact ggcaggacag cgaggggaac acagccctaa   1860

tcacagctgc acaggcaggg cacgctatca tcactaacta cttgttgaac tatttccctg   1920

gtcttgacct tgaaaggagg aacgcgttcg ggttcaccgc cctgatgaaa gccgccatgc   1980

agggtcgaac ggactgcatc cgagccctga tgctagcagg ggcggatgtc cacgcgaggg   2040

acccccgccg tgggatgtcg ccgcaggagt gggccactta cacgggccgc gtggatgccg   2100

tccgtctcat gcagaggctg ctggagcgcc cctgcccgga gcagttctgg gagaagtacc   2160

ggcccgagct gccgccgccc cctgaagcgg cgcggaagcc cgcgggctcc aagaactgcc   2220

tgcagaggct cacagactgc gtgctgtccg tgctgacgcc gcgctccgtg cggggcccgg   2280

aggacggggg cgtcctggac cacatggtcc ggatgaccac gagcctctac agccccgccg   2340

tggccatcgt gtgccagacc gtgtgccctg agagccctcc gagcgtgggg aagaggcggc   2400

tggcggtgca ggagatcctg gcggcgcggg ctgcacgggg cccccaggcg caggaggagg   2460

atgaggtggg gggcgcgggg cagcgcgggc ggaccggaca ggaggacgcg gactcccggg   2520

agggctcccc gagagccggc ctccctcccg ccctggggtc ccggggcccc gcagcgcccg   2580

ccccgcggaa ggccagcctc ctgcccctgc agcgcctgcg gcggagaagc gtgcggcccg   2640

gtgtggtggt gccccgggtc cgagtcagca aggcgcccgc gcccaccttc cagcccgagc   2700

ggccggcgcg gaagggcagc accaaggaca gcggccacct gcagatcccc aagtggcggt   2760

acaaggaggc caaggaggag aagaggaagg cagaggaggc cgaaaagaag cgccaggccg   2820

aggcgcagaa ggagaggcgc actgcgccct ggaagaagag gacgtga                 2867


<210>  2603
<211>  494
<212>  PRT
<213>  Homo sapiens

<400>  2603

Met Val Leu Leu Ala Gly Thr Gly Pro Glu Gly Gly Gly Ala Arg Cys 
1               5                   10                  15


Met Thr Pro Pro Pro Pro Ser Pro Pro Arg Gly Ala Gln Val Glu Glu 
            20                  25                  30


Asp Pro Ala Asp Tyr Glu Glu Phe Glu Asp Phe Ser Ser Leu Pro Asp 
        35                  40                  45


Thr Arg Ser Ile Ala Ser Asp Asp Ser Phe Tyr Pro Phe Glu Asp Glu 
    50                  55                  60


Glu Glu His Gly Val Glu Ser Ala Glu Ser Val Pro Glu Gly Val Pro 
65                  70                  75                  80


Glu Ser Val Pro Glu Thr Ala Thr Leu Leu Arg Ala Ala Cys Ala Asn 
                85                  90                  95


Asn Val Gly Leu Leu Arg Thr Leu Val Arg Arg Gly Val Ser Val Glu 
            100                 105                 110


Glu Ala Gln Glu Thr Asp Arg Asn Gly Arg Thr Gly Leu Ile Val Ala 
        115                 120                 125


Cys Tyr His Gly Phe Val Asp Thr Val Val Ala Leu Ala Glu Cys Pro 
    130                 135                 140


His Val Asp Val Asn Trp Gln Asp Ser Glu Gly Asn Thr Ala Leu Ile 
145                 150                 155                 160


Thr Ala Ala Gln Ala Gly His Ala Ile Ile Thr Asn Tyr Leu Leu Asn 
                165                 170                 175


Tyr Phe Pro Gly Leu Asp Leu Glu Arg Arg Asn Ala Phe Gly Phe Thr 
            180                 185                 190


Ala Leu Met Lys Ala Ala Met Gln Gly Arg Thr Asp Cys Ile Arg Ala 
        195                 200                 205


Leu Met Leu Ala Gly Ala Asp Val His Ala Arg Asp Pro Arg Arg Gly 
    210                 215                 220


Met Ser Pro Gln Glu Trp Ala Thr Tyr Thr Gly Arg Val Asp Ala Val 
225                 230                 235                 240


Arg Leu Met Gln Arg Leu Leu Glu Arg Pro Cys Pro Glu Gln Phe Trp 
                245                 250                 255


Glu Lys Tyr Arg Pro Glu Leu Pro Pro Pro Pro Glu Ala Ala Arg Lys 
            260                 265                 270


Pro Ala Gly Ser Lys Asn Cys Leu Gln Arg Leu Thr Asp Cys Val Leu 
        275                 280                 285


Ser Val Leu Thr Pro Arg Ser Val Arg Gly Pro Glu Asp Gly Gly Val 
    290                 295                 300


Leu Asp His Met Val Arg Met Thr Thr Ser Leu Tyr Ser Pro Ala Val 
305                 310                 315                 320


Ala Ile Val Cys Gln Thr Val Cys Pro Glu Ser Pro Pro Ser Val Gly 
                325                 330                 335


Lys Arg Arg Leu Ala Val Gln Glu Ile Leu Ala Ala Arg Ala Ala Arg 
            340                 345                 350


Gly Pro Gln Ala Gln Glu Glu Asp Glu Val Gly Gly Ala Gly Gln Arg 
        355                 360                 365


Gly Arg Thr Gly Gln Glu Asp Ala Asp Ser Arg Glu Gly Ser Pro Arg 
    370                 375                 380


Ala Gly Leu Pro Pro Ala Leu Gly Ser Arg Gly Pro Ala Ala Pro Ala 
385                 390                 395                 400


Pro Arg Lys Ala Ser Leu Leu Pro Leu Gln Arg Leu Arg Arg Arg Ser 
                405                 410                 415


Val Arg Pro Gly Val Val Val Pro Arg Val Arg Val Ser Lys Ala Pro 
            420                 425                 430


Ala Pro Thr Phe Gln Pro Glu Arg Pro Ala Arg Lys Gly Ser Thr Lys 
        435                 440                 445


Asp Ser Gly His Leu Gln Ile Pro Lys Trp Arg Tyr Lys Glu Ala Lys 
    450                 455                 460


Glu Glu Lys Arg Lys Ala Glu Glu Ala Glu Lys Lys Arg Gln Ala Glu 
465                 470                 475                 480


Ala Gln Lys Glu Arg Arg Thr Ala Pro Trp Lys Lys Arg Thr 
                485                 490


<210>  2604
<211>  669
<212>  DNA
<213>  Homo sapiens

<400>  2604
gggagttgac tgccgttgag cgggtaggaa agtgccttcc aggtacaggc agcaggagtg     60

gtgattgtct tggtagagga tgggtgaact gcaaatagag ttgaaggagc tgggctgagt    120

agttgggatt tcactccccg ggtgattggt gggacccagc agggccaaat cctccagtgg    180

ggcctgatgg gcagaggaga gacttggaca cccttaagag acgaaatgaa tcttcagagg    240

ttcagccatt gcttgcaatg tcatcttctg ggctcatccc tgcactccaa ccctggacat    300

tttctctggt cttttctagt ggccaccatc tggatgatta cgactctgga aatctctgtc    360

catcatccat ttttttgcct cctctgtgaa cgagcaggtg tgatggcctg aaaacagaga    420

gggagaaggc tgagtgtacc agggcagggg aagcgcttcc tggaattacg tgtcccagga    480

caaaagtgaa actgccttcg ctgactcata ggaaagtttg aaaatatcat gtttcgccta    540

tgcctggggg atctttgttt ttggcataag ccgaacagat tgttccaggc cagaaaaaaa    600

ctaagccaaa ccaaaacaac agaatgactt aattatgtac cagcaccctt taaaattaat    660

tatgcttgc                                                            669


<210>  2605
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  2605

Met Gly Arg Gly Glu Thr Trp Thr Pro Leu Arg Asp Glu Met Asn Leu 
1               5                   10                  15


Gln Arg Phe Ser His Cys Leu Gln Cys His Leu Leu Gly Ser Ser Leu 
            20                  25                  30


His Ser Asn Pro Gly His Phe Leu Trp Ser Phe Leu Val Ala Thr Ile 
        35                  40                  45


Trp Met Ile Thr Thr Leu Glu Ile Ser Val His His Pro Phe Phe Cys 
    50                  55                  60


Leu Leu Cys Glu Arg Ala Gly Val Met Ala 
65                  70


<210>  2606
<211>  488
<212>  DNA
<213>  Homo sapiens

<400>  2606
cagtttcatc ccctgtggtg ggagtggtct gggcacccta cttttcaatc aagacgaata     60

gagtggggga actcttcaaa cttagaaagg gccaggggct gtgctaacat gtgttcacct    120

cctcaggttt cgaagcgtga ggcatcactt ccatggaggg ttccaggctt tgaaaaccta    180

gcaagagtgt gaaagggctt ttgctgaagt tatcccaaac ccagccagtt ggtaaccctg    240

aagatggctc cagtgtcctt ttgtcatatt tctgtcagtt ttgagtattt tcttgattta    300

tggcacacca aagtgttcca cattctccct ggactttccc agtccctgtc tgtaaccagc    360

tgtatcttca aggaatgata gttctttttt tagtgaggaa tggtatttag aaaccaaaat    420

ctggactcta gctgtgctca ttcacactaa atgttattgc ttctaggcat ttcagtgagc    480

agagttag                                                             488


<210>  2607
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  2607

Met Ala Pro Val Ser Phe Cys His Ile Ser Val Ser Phe Glu Tyr Phe 
1               5                   10                  15


Leu Asp Leu Trp His Thr Lys Val Phe His Ile Leu Pro Gly Leu Ser 
            20                  25                  30


Gln Ser Leu Ser Val Thr Ser Cys Ile Phe Lys Glu 
        35                  40


<210>  2608
<211>  392
<212>  DNA
<213>  Homo sapiens

<400>  2608
atgggataca gcacgtgaag cttgttttgg gtataaggaa cctctgatgt gtgcttgcaa     60

cttgttattt cttgcattta attgtaaaat tctgaggcta cgtgctgaga gccagcctgg    120

caggatgccc tgcctgccct gcaaagagca gggatgctgc cctcccctac taaccctgcc    180

cctccatctg catggtaaat gccttatgct aagaattcct ggagtctgtt catgccgcgt    240

ggctggtatg atgtcatatt tccaaagccg acagctccct ctactggcct ggtctggaga    300

actgcagttt gagtgccttg agtcagtcaa tcttagacaa cccaattctg taacattttc    360

caatttttag agcagtttgt gtttattgcc tg                                  392


<210>  2609
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  2609

Met Cys Ala Cys Asn Leu Leu Phe Leu Ala Phe Asn Cys Lys Ile Leu 
1               5                   10                  15


Arg Leu Arg Ala Glu Ser Gln Pro Gly Arg Met Pro Cys Leu Pro Cys 
            20                  25                  30


Lys Glu Gln Gly Cys Cys Pro Pro Leu Leu Thr Leu Pro Leu His Leu 
        35                  40                  45


His Gly Lys Cys Leu Met Leu Arg Ile Pro Gly Val Cys Ser Cys Arg 
    50                  55                  60


Val Ala Gly Met Met Ser Tyr Phe Gln Ser Arg Gln Leu Pro Leu Leu 
65                  70                  75                  80


Ala Trp Ser Gly Glu Leu Gln Phe Glu Cys Leu Glu Ser Val Asn Leu 
                85                  90                  95


Arg Gln Pro Asn Ser Val Thr Phe Ser Asn Phe 
            100                 105


<210>  2610
<211>  4239
<212>  DNA
<213>  Homo sapiens

<400>  2610
cgcctaatct tcacccgctg ctaggctcgt ttaatgagtc ttctgagagc taaggagtcc     60

tcggattcat tcaaagcatt ctacaatgaa cgctaggggg gaaaaagaac aaacaaaata    120

catttcaaat ataggattca attacttttc actactcaat gatgtgtcaa aggcacgctg    180

tgttttgttt tgagggcggg gagatgacag gagggaatcc tgggccccca ttggctcgcc    240

gctcgccgct gcagttgagc tccagccgct ccgagagcat tattgatctg aagggtaaat    300

gtggagggag ccacagagag gggtccaggc ttttctgaga agagaggcag cctcttccag    360

gaagaaagtg gtgtctactg gctgcccggc ctggagaacc ttctttgaat gaaaacggac    420

aaaatgcaaa gcagtgtgtt ggcacagtga tttggaaagg ggaaacagaa gagaagggtc    480

tcaccttccg cgcaaggctg agctgttggc accctgctgc ggccgtcggt gctgctgctc    540

ctgcagctgc cttttctgcc atcagctttg ttacctaaca gcttggctct tttgggaaat    600

atagacaagc tggaacccag gagcagttgg gagttttaaa gaatgccagc ctttttaaag    660

ctttgatgtc cagtgctata gaatcaagtt actgtggagg tcaaaacaat ttgagataca    720

taagctggcc ttagaaaata aattgcctct aacttacagt gaggagctca acataacagg    780

gaaaaggagc acaggatgca gctacttgga gggtgttgat tgaaaacttc gatctcccca    840

ccccattcac ggttgatttg acggatttct cacctcgttc acagagaaaa tttcaattaa    900

ggccccttta gatggaatat aatacagcag aagccttttc atcaaaagga ttaatgcctg    960

catcatcatt tctgcaataa aacaagaagc taagtggtgg aggccacaga cacctcaaac   1020

ctggattcca caattctacg ttaagtgttg gagtttttat tactctgctg taggaaagcc   1080

tttgccaatg cttacaagga actgtttatc cctgcttctc tgggttctgt ttgatggagg   1140

tctcctaaca ccactacaac cacagccaca gcagacttta gccacagagc caagagaaaa   1200

tgttatccat ctgccaggac aacggtcaca tttccaacgt gttaaacgtg gctgggtatg   1260

gaatcaattt tttgtgctgg aagaatacgt gggctccgag cctcagtatg tgggaaagct   1320

ccattccgac ttagacaagg gagagggcac tgtgaaatac accctctcag gagatggcgc   1380

tggcaccgtt tttaccattg atgaaaccac aggggacatt catgcaataa ggagcctaga   1440

tagagaagag aaacctttct acactcttcg tgctcaggct gtggacatag aaaccagaaa   1500

gcccctggag cctgaatcag aattcatcat caaagtgcag gatattaatg ataatgagcc   1560

aaagtttttg gatggacctt atgttgctac tgttccagaa atgtctcctg tgggtgcata   1620

tgtactccag gtcaaggcca cagatgcaga tgacccgacc tatggaaaca gtgccagagt   1680

cgtttacagc attcttcagg gacaacctta tttctctatt gatcccaaga caggtgttat   1740

tagaacagct ttgccaaaca tggacagaga agtcaaagaa caatatcaag tactcatcca   1800

agccaaggat atgggaggac agcttggagg attagccgga acaacaatag tcaacatcac   1860

tctcaccgat gtcaatgaca atccacctcg attccccaaa agcatcttcc acttgaaagt   1920

tcctgagtct tcccctattg gttcagctat tggaagaata agagctgtgg atcctgattt   1980

tggacaaaat gcagaaattg aatacaatat tgttccagga gatgggggaa atttgtttga   2040

catcgtcaca gatgaggata cacaagaggg agtcatcaaa ttgaaaaagc ctttagattt   2100

tgaaacaaag aaggcataca ctttcaaagt tgaggcttcc aaccttcacc ttgaccaccg   2160

gtttcactcg gcgggccctt tcaaagacac agctacggtg aagatcagcg tgctggacgt   2220

agatgagcca ccggttttca gcaagccgct ctacaccatg gaggtttatg aagacactcc   2280

ggtagggacc atcattggcg ctgtcactgc tcaagacctg gatgtaggca gcagtgctgt   2340

taggtacttc atagattgga agagtgatgg ggacagctac tttacaatag atggaaatga   2400

aggaaccatc gccactaatg aattactaga cagagaaagc actgcgcagt ataatttctc   2460

cataattgcg agtaaagtta gtaacccttt attgaccagc aaagtcaata tactgattaa   2520

tgtcttagat gtaaatgaat ttcctccaga aatatctgtg ccatatgaga cagccgtgtg   2580

tgaaaatgcc aagccaggac agataattca gatagtcagt gctgcagacc gagatctttc   2640

acctgctggg caacaattct cctttagatt atcacctgag gctgctatca aaccaaattt   2700

tacagttcgt gacttcagaa acaacacagc ggggattgaa acccgaagaa atggatacag   2760

ccgcaggcag caagagttgt atttcctccc tgttgtaata gaagacagca gctaccctgt   2820

ccagagcagc acaaacacaa tgactattcg agtctgtaga tgtgactctg atggcaccat   2880

cctgtcttgt aatgtggaag caatttttct acctgtagga cttagcactg gggcgttgat   2940

tgcaattcta ctatgcattg ttatactctt agccatagtt gtactgtatg tagcactgcg   3000

aaggcagaag aaaaaagaca ccctgatgac ctctaaagaa gacatcagag acaacgtcat   3060

ccattacgat gatgaaggag gtggggagga agatacccag gctttcgaca tcggggctct   3120

gagaaaccca aaagtgattg aggagaacaa aattcgcagg gatataaaac cagactctct   3180

ctgtttacct cgtcagagac cacccatgga agataacaca gacataaggg atttcattca   3240

tcaaaggcta caggaaaatg atgtggatcc aactgcccca ccatacgatt cactggccac   3300

atatgcctac gaagggagtg ggtccgtggc agagtccctc agctctatag actctctcac   3360

cacagaagcc gaccaggact atgactatct gacagactgg ggaccccgct ttaaagtctt   3420

ggcagacatg tttggcgaag aagagagtta taaccctgat aaagtcactt aagggagtcg   3480

tggaggctaa aatacaaccg agaggggaga tttttaaaaa agaaaaagaa acacaaatat   3540

taatagaaat ctctctcaca cacacacaca cacacaaaca cacacacaca cacacacact   3600

ctgggacaag attcctttga ttacctggtt tctagtaagt tactaaatta atcatattgt   3660

cagttttggt ttattctgcc aacaagagat acatcctata atgtgtactt gctttgtttt   3720

gttgttttgt tttttcacaa tcacactgag acaagctcag gcctattcaa tacaatttac   3780

tgacatgaca acctagaacg aagatagcta tgtggcatca cggtggaaga gtgttagatt   3840

tttcttaatt ccactaaagt gcctattgaa actcttatca tttaaagtgg tgtacagtac   3900

actctgctgt gatggtattg cgggattcag agataaagac ataaaacaaa gacaccgtct   3960

ttatgtcaag aagcaatagc gacactctga ctctcctcat tccttttgag aacaaaagaa   4020

gaacactttc tgatctccac cttcttctaa ttcaaaaggt tttctttttc ttttttaaac   4080

tgtatgctaa aacgtatttg tttatcctat cctttcagaa aattgaaata aatatgaaaa   4140

tatcaagttc aatatgtaag tcccaaattc tagaaacaat gtttgatctt aacattagtt   4200

cacattaaag ctgttcatta aaatgttact ttcttttcc                          4239


<210>  2611
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  2611

Met Leu Thr Arg Asn Cys Leu Ser Leu Leu Leu Trp Val Leu Phe Asp 
1               5                   10                  15


Gly Gly Leu Leu Thr Pro Leu Gln Pro Gln Pro Gln Gln Thr Leu Ala 
            20                  25                  30


Thr Glu Pro Arg Glu Asn Val Ile His Leu Pro Gly Gln Arg Ser His 
        35                  40                  45


Phe Gln Arg Val Lys Arg Gly Trp Val Trp Asn Gln Phe Phe Val Leu 
    50                  55                  60


Glu Glu Tyr Val Gly Ser Glu Pro Gln Tyr Val Gly Lys Leu His Ser 
65                  70                  75                  80


Asp Leu Asp Lys Gly Glu Gly Thr Val Lys Tyr Thr Leu Ser Gly Asp 
                85                  90                  95


Gly Ala Gly Thr Val Phe Thr Ile Asp Glu Thr Thr Gly Asp Ile His 
            100                 105                 110


Ala Ile Arg Ser Leu Asp Arg Glu Glu Lys Pro Phe Tyr Thr Leu Arg 
        115                 120                 125


Ala Gln Ala Val Asp Ile Glu Thr Arg Lys Pro Leu Glu Pro Glu Ser 
    130                 135                 140


Glu Phe Ile Ile Lys Val Gln Asp Ile Asn Asp Asn Glu Pro Lys Phe 
145                 150                 155                 160


Leu Asp Gly Pro Tyr Val Ala Thr Val Pro Glu Met Ser Pro Val Gly 
                165                 170                 175


Ala Tyr Val Leu Gln Val Lys Ala Thr Asp Ala Asp Asp Pro Thr Tyr 
            180                 185                 190


Gly Asn Ser Ala Arg Val Val Tyr Ser Ile Leu Gln Gly Gln Pro Tyr 
        195                 200                 205


Phe Ser Ile Asp Pro Lys Thr Gly Val Ile Arg Thr Ala Leu Pro Asn 
    210                 215                 220


Met Asp Arg Glu Val Lys Glu Gln Tyr Gln Val Leu Ile Gln Ala Lys 
225                 230                 235                 240


Asp Met Gly Gly Gln Leu Gly Gly Leu Ala Gly Thr Thr Ile Val Asn 
                245                 250                 255


Ile Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Arg Phe Pro Lys Ser 
            260                 265                 270


Ile Phe His Leu Lys Val Pro Glu Ser Ser Pro Ile Gly Ser Ala Ile 
        275                 280                 285


Gly Arg Ile Arg Ala Val Asp Pro Asp Phe Gly Gln Asn Ala Glu Ile 
    290                 295                 300


Glu Tyr Asn Ile Val Pro Gly Asp Gly Gly Asn Leu Phe Asp Ile Val 
305                 310                 315                 320


Thr Asp Glu Asp Thr Gln Glu Gly Val Ile Lys Leu Lys Lys Pro Leu 
                325                 330                 335


Asp Phe Glu Thr Lys Lys Ala Tyr Thr Phe Lys Val Glu Ala Ser Asn 
            340                 345                 350


Leu His Leu Asp His Arg Phe His Ser Ala Gly Pro Phe Lys Asp Thr 
        355                 360                 365


Ala Thr Val Lys Ile Ser Val Leu Asp Val Asp Glu Pro Pro Val Phe 
    370                 375                 380


Ser Lys Pro Leu Tyr Thr Met Glu Val Tyr Glu Asp Thr Pro Val Gly 
385                 390                 395                 400


Thr Ile Ile Gly Ala Val Thr Ala Gln Asp Leu Asp Val Gly Ser Ser 
                405                 410                 415


Ala Val Arg Tyr Phe Ile Asp Trp Lys Ser Asp Gly Asp Ser Tyr Phe 
            420                 425                 430


Thr Ile Asp Gly Asn Glu Gly Thr Ile Ala Thr Asn Glu Leu Leu Asp 
        435                 440                 445


Arg Glu Ser Thr Ala Gln Tyr Asn Phe Ser Ile Ile Ala Ser Lys Val 
    450                 455                 460


Ser Asn Pro Leu Leu Thr Ser Lys Val Asn Ile Leu Ile Asn Val Leu 
465                 470                 475                 480


Asp Val Asn Glu Phe Pro Pro Glu Ile Ser Val Pro Tyr Glu Thr Ala 
                485                 490                 495


Val Cys Glu Asn Ala Lys Pro Gly Gln Ile Ile Gln Ile Val Ser Ala 
            500                 505                 510


Ala Asp Arg Asp Leu Ser Pro Ala Gly Gln Gln Phe Ser Phe Arg Leu 
        515                 520                 525


Ser Pro Glu Ala Ala Ile Lys Pro Asn Phe Thr Val Arg Asp Phe Arg 
    530                 535                 540


Asn Asn Thr Ala Gly Ile Glu Thr Arg Arg Asn Gly Tyr Ser Arg Arg 
545                 550                 555                 560


Gln Gln Glu Leu Tyr Phe Leu Pro Val Val Ile Glu Asp Ser Ser Tyr 
                565                 570                 575


Pro Val Gln Ser Ser Thr Asn Thr Met Thr Ile Arg Val Cys Arg Cys 
            580                 585                 590


Asp Ser Asp Gly Thr Ile Leu Ser Cys Asn Val Glu Ala Ile Phe Leu 
        595                 600                 605


Pro Val Gly Leu Ser Thr Gly Ala Leu Ile Ala Ile Leu Leu Cys Ile 
    610                 615                 620


Val Ile Leu Leu Ala Ile Val Val Leu Tyr Val Ala Leu Arg Arg Gln 
625                 630                 635                 640


Lys Lys Lys Asp Thr Leu Met Thr Ser Lys Glu Asp Ile Arg Asp Asn 
                645                 650                 655


Val Ile His Tyr Asp Asp Glu Gly Gly Gly Glu Glu Asp Thr Gln Ala 
            660                 665                 670


Phe Asp Ile Gly Ala Leu Arg Asn Pro Lys Val Ile Glu Glu Asn Lys 
        675                 680                 685


Ile Arg Arg Asp Ile Lys Pro Asp Ser Leu Cys Leu Pro Arg Gln Arg 
    690                 695                 700


Pro Pro Met Glu Asp Asn Thr Asp Ile Arg Asp Phe Ile His Gln Arg 
705                 710                 715                 720


Leu Gln Glu Asn Asp Val Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu 
                725                 730                 735


Ala Thr Tyr Ala Tyr Glu Gly Ser Gly Ser Val Ala Glu Ser Leu Ser 
            740                 745                 750


Ser Ile Asp Ser Leu Thr Thr Glu Ala Asp Gln Asp Tyr Asp Tyr Leu 
        755                 760                 765


Thr Asp Trp Gly Pro Arg Phe Lys Val Leu Ala Asp Met Phe Gly Glu 
    770                 775                 780


Glu Glu Ser Tyr Asn Pro Asp Lys Val Thr 
785                 790


<210>  2612
<211>  539
<212>  DNA
<213>  Homo sapiens

<400>  2612
actgcaagct ccgcctcccg ggttcacgcc attctcctgc ctcagcctcc agagtagctg     60

ggactacagg cgcccgccat cacgcccggc taattttttt gtatttttaa tagagacggg    120

gtttcacctt gttagccagg atggtctcaa tctcctgacc tcgtgatatg cctacctcgg    180

cctcccgaag tgctgggatt acattctcca ggcattctta cctgacgacc actcctgaca    240

gagaaagtgc tcacagcctg tccttgtgta actcctgagc atacctctac catcaagctt    300

tgttacctaa cagcttggct cttttgggaa atatagacaa gctggaaccc aggagcagtt    360

gggagtttta aagaatgcca gcctttttaa agctttgatg tccagtgcta tagaatcaag    420

ttactgtgga ggtcaaaaca atttgagata cataagctgg ccttagaaaa taaattgcct    480

ctaacttgta taagtcgaat gtccctgttt ccagaatatg gtgttcagtc tgccacatg     539


<210>  2613
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  2613

Met Pro Thr Ser Ala Ser Arg Ser Ala Gly Ile Thr Phe Ser Arg His 
1               5                   10                  15


Ser Tyr Leu Thr Thr Thr Pro Asp Arg Glu Ser Ala His Ser Leu Ser 
            20                  25                  30


Leu Cys Asn Ser 
        35


<210>  2614
<211>  487
<212>  DNA
<213>  Homo sapiens

<400>  2614
agaagctgtt ttcagagatt cagaggcagg cagatgacca cagcaagaag aacagacaga     60

aatccgtaag gataattcgt ctaagctaat tatagttaaa gcattactga cttataaaaa    120

ctcaggatta tgctctcaaa ggcaatcaca tttatattat ttttatttaa aatatatatt    180

acatgtaata taaactatac acacaatata ttgaactata tggaaattga aactgtgaaa    240

tcccgtactg ggctgcacct cttttattga ctactatttt cttaccacat ttggtgacac    300

agcatacgtg ctcccaatca cattcaatga ttcttaatca gttctcctac cactctcctc    360

cacacactga catatgcatc aattattcat ggctattatc ctttattggc aaaacctgat    420

tcagacaaga agcagcacat agtttcttct atgtggaaaa aataaactat ttttttaata    480

tcaataa                                                              487


<210>  2615
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  2615

Met Leu Ser Lys Ala Ile Thr Phe Ile Leu Phe Leu Phe Lys Ile Tyr 
1               5                   10                  15


Ile Thr Cys Asn Ile Asn Tyr Thr His Asn Ile Leu Asn Tyr Met Glu 
            20                  25                  30


Ile Glu Thr Val Lys Ser Arg Thr Gly Leu His Leu Phe Tyr 
        35                  40                  45


<210>  2616
<211>  275
<212>  DNA
<213>  Homo sapiens

<400>  2616
aggcaaattt cttgaagtgg ataatgctgg gtcaaatatt gacattccat ggaagattgt     60

cccatgtaca taccaaaaag aaaaataaaa aacctggact gctgtgtctc ctatgacaac    120

tcttgctgct gaaagatgtc tcaagttatc cactgctatg tttcctttcc tgttttgtgt    180

ccttccaagt gaagccagca ccaagtacag cctacttaag tcccattttg tcttttttta    240

tcactcccta ttgaaataaa gtccacccaa atgag                               275


<210>  2617
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  2617

Met Thr Thr Leu Ala Ala Glu Arg Cys Leu Lys Leu Ser Thr Ala Met 
1               5                   10                  15


Phe Pro Phe Leu Phe Cys Val Leu Pro Ser Glu Ala Ser Thr Lys Tyr 
            20                  25                  30


Ser Leu Leu Lys Ser His Phe Val Phe Phe Tyr His Ser Leu Leu Lys 
        35                  40                  45


<210>  2618
<211>  1604
<212>  DNA
<213>  Homo sapiens

<400>  2618
ctgggaatca atgtgtgagg tggtgctatg tagcaggaac ccctcttgct ttgcaaatag     60

ttttttgttt gttttccttt ttgcccaata gagccctgct ctactgaccc ttcaatgtgc    120

ccgtgtgcct aaatattcct ggtcgtgtga aaagaaccca ggtattagct gaactaagga    180

gcacaattct gcaacatttt ggcacccaaa cacggggctt gagaaatgaa tgcaattgga    240

gaaactggtt gttttaccag gcgttgattg gaaatgtgtg cttcccttta agcagtcaag    300

ctcaacttgc agaactgatg ggaacccctt gggaaaactg gcctcaaatg tttgtctaca    360

cagtccacat acagggttct taacctgcgg aaacactttc tgaaaatgtc agaactcttg    420

aaaacatgga tgaggaaaag cataagtact gctttatgct tttcttatga attttaaaag    480

atgtaattta aaggtacttt aaagtgatat ttgtgccctt gtaactgatt caaagtagac    540

tgctaaggac aataagtaat aagagtctac aaatatcagt aaattatgag aaaaaacggt    600

ctaatggtac ttaaaattgc attgtgattt attaaataac attgaacagc tccacctgta    660

acattaagat tccatttgag catatagaaa atatatttat cgcaacctga agtgatttgg    720

aaagtatgct gggaagaaaa tatatttaca aattagtctc agagggtagg tatcctgtag    780

ccagatggaa taagaagaga gggaagggag attttgttca aagggggagc ataagctaag    840

gaataaagcc acaaacaatg attaaattag gtaaagtgca attagctgaa tattgcataa    900

gcatacatat gggaagaagt ggaaaaagga gtgacaatat gaagctaaag ggtttgaagt    960

gttcaagata atactaggct tcctagccta ttccgagaca tcttgtttta gagtgcaata   1020

gataagaact ctaaggatga aagtaggaga catgcattct agtctacgtt ttggttaatg   1080

gactgaaagt gaaagatgga ctgaaattgg gggatggaat aaaaatgtga tagaatagaa   1140

aatagaaaaa gcaattagcc taatgtcatt gatacttaga gaaaatatgg aaaatagtaa   1200

attagtgata tatatctttt ctaattcacc agggtgagtg aacaaaggaa atcggattta   1260

aaagtattca tgacatagat gcaataaggt ttctcagtca gacatagcaa attgagggaa   1320

gggaagattt agaggattgg aaaatgtctt gcttgtagac taataggata tcaataagcc   1380

atatgagcaa taatttgaaa tagtttttgt aaagtatcat gaaggtaaac cctgtttaga   1440

acaaattaga tttgaagtac ttgtgacaaa tgcaattgac aatgccttta tgcagctgga   1500

aaattgttgc ttagcagaaa agcttgtgct ggacaaatag atgtccaaat tgaatagatg   1560

ttttcttaag ctgaactaat tgagacaaat atccttatta aatc                    1604


<210>  2619
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  2619

Met Gln Leu Glu Lys Leu Val Val Leu Pro Gly Val Asp Trp Lys Cys 
1               5                   10                  15


Val Leu Pro Phe Lys Gln Ser Ser Ser Thr Cys Arg Thr Asp Gly Asn 
            20                  25                  30


Pro Leu Gly Lys Leu Ala Ser Asn Val Cys Leu His Ser Pro His Thr 
        35                  40                  45


Gly Phe Leu Thr Cys Gly Asn Thr Phe 
    50                  55


<210>  2620
<211>  1104
<212>  DNA
<213>  Homo sapiens

<400>  2620
ctgggaatca atgtgtgagg tggtgctatg tagcaggaac ccctcttgct ttgcaaatag     60

ttttttgttt gttttccttt ttgcccaata gagccctgct ctactgaccc ttcaatgtgc    120

ccgtgtgcct aaatattcct ggtcgtgtga aaagaaccca ggtattagct gaactaagga    180

gcacaattct gcaacatttt ggcacccaaa cacggggctt gagaaatgaa tgcaattgga    240

gaaactggtt gttttaccag gcgttgattg gaaatgtgtg cttcccttta agcagtcaag    300

ctcaacttgc agaactgatg ggaacccctt gggaaaactg gcctcaaatg tttgtctaca    360

cagtccacat acagggttct taacctgcga tgagggaaac ttcccagggc ttgtctgggt    420

atgcccacag tggactggag cccaaaatgc acactggagg aagtggatgg agccacgtgg    480

atgtcatgcc ttatgcaggg gaggagcctg ctctcttcag ctcctgtggt aatgtgggaa    540

tcgatctgtg agcatattta actatccggc tattttggag attgaaaaaa gaagacctga    600

tttatcatgt gcaatatctc acacatctgt catttctatt ctaccgcaat tcgatggagt    660

cttgttctgt ggtccaggct agagggcagt ggcatgatct cggctcacta caagctctgc    720

ctcccgggtt cacgccattc tcctgcctca gcctcctgag tagctgggac tacaggcgcc    780

cgccaccacg cctggctaat tttttgtata tttactagag atggctagtg ttagccaaga    840

tggtctcgat ctcctgacct cgtgatctgc ccacctcagc ctgccaaagt gctgggatta    900

ctggcgtgag ccaccgtgcc tggccagcat cctctaatta ttattcatag tttgtgaatt    960

taggcctacg tgaataataa tataatattt actatgatgt tactatctac caaccttatt   1020

tttcttttct ataaaatagg agccaaaata atatttatgt cataccttat gaagttaaaa   1080

taaaatataa cgaatgaggg gctt                                          1104


<210>  2621
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  2621

Met Gln Leu Glu Lys Leu Val Val Leu Pro Gly Val Asp Trp Lys Cys 
1               5                   10                  15


Val Leu Pro Phe Lys Gln Ser Ser Ser Thr Cys Arg Thr Asp Gly Asn 
            20                  25                  30


Pro Leu Gly Lys Leu Ala Ser Asn Val Cys Leu His Ser Pro His Thr 
        35                  40                  45


Gly Phe Leu Thr Cys Asp Glu Gly Asn Phe Pro Gly Leu Val Trp Val 
    50                  55                  60


Cys Pro Gln Trp Thr Gly Ala Gln Asn Ala His Trp Arg Lys Trp Met 
65                  70                  75                  80


Glu Pro Arg Gly Cys His Ala Leu Cys Arg Gly Gly Ala Cys Ser Leu 
                85                  90                  95


Gln Leu Leu Trp 
            100


<210>  2622
<211>  667
<212>  DNA
<213>  Homo sapiens

<400>  2622
tgaggtggtg ctatgtagca ggaacccctc ttgctttgca aatagttttt tgtttgtttt     60

cctttttgcc caatagagcc ctgctctact gacccttcaa tgtgcccgtg tgcctaaata    120

ttcctggtcg tgtgaaaaga acccaggtat tagctgaact aaggagcaca attctgcaac    180

attttggcac ccaaacacgg ggcttgagaa atgaatgcaa ttggagaaac tggttgtttt    240

accaggcgtt gattggaaat gtgtgcttcc ctttaagcag tcaagctcaa cttgcagaac    300

tgatgggaac cccttgggaa aactggcctc aaatgtttgt ctacacagtc cacatacagg    360

gttcttaacc tgcggaaaca ctttctgaaa atgtcagaac tcttgaaaac atggatgagg    420

aaaagcataa gtactgcttt atgcttttct tatgaatttt aaaagatgta atttaaagat    480

tgaaactccc acaactttgg cagaccaact cctcagaaaa cattattctt tgacatcaat    540

atgttttgca caaaattgaa tggcaagtga aaggcatcaa atgcatattt aactatccgg    600

ctattttgga gattgaaaaa agaagacctg atttatcatg tgcaatatct cacacatctg    660

tcatttc                                                              667


<210>  2623
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  2623

Met Gln Leu Glu Lys Leu Val Val Leu Pro Gly Val Asp Trp Lys Cys 
1               5                   10                  15


Val Leu Pro Phe Lys Gln Ser Ser Ser Thr Cys Arg Thr Asp Gly Asn 
            20                  25                  30


Pro Leu Gly Lys Leu Ala Ser Asn Val Cys Leu His Ser Pro His Thr 
        35                  40                  45


Gly Phe Leu Thr Cys Gly Asn Thr Phe 
    50                  55


<210>  2624
<211>  946
<212>  DNA
<213>  Homo sapiens

<400>  2624
tgaggtggtg ctatgtagca ggaacccctc ttgctttgca aatagttttt tgtttgtttt     60

cctttttgcc caatagagcc ctgctctact gacccttcaa tgtgcccgtg tgcctaaata    120

ttcctggtcg tgtgaaaaga acccaggtat tagctgaact aaggagcaca attctgcaac    180

attttggcac ccaaacacgg ggcttgagaa atgaatgcaa ttggagaaac tggttgtttt    240

accaggcgtt gattggaaat gtgtgcttcc ctttaagcag tcaagctcaa cttgcagaac    300

tgatgggaac cccttgggaa aactggcctc aaatgtttgt ctacacagtc cacatacagg    360

gttcttaacc tgcgatgagg gaaacttccc agggcttgtc tgggtatgcc cacagtggac    420

tggagcccaa aatgcacact ggaggaagtg gatggagcca cgtggatgtc atgccttatg    480

caggggagga gcctgctctc ttcagctcct gtggtaatgt gggaatcgat ctgtgaggaa    540

acactttctg aaaatgtcag aactcttgaa aacatggatg aggaaaagca taagtactgc    600

tttatgcttt tcttatgaat tttaaaagat gtaatttaaa gattgaaact cccacaactt    660

tggcagacca actcctcaga aaacattatt ctttgacatc aatatgtttt gcacaaaatt    720

gaatggcaag tgaaaggcat caaatggagc tgtcatttaa atgtgcttgc caactagctt    780

gtttatcaaa acattccaga ccctttcaaa ttctcattta cattgtttct tgtttaccac    840

acccataaat ttgtattacc agcatattta actatccggc tattttggag attgaaaaaa    900

gaagacctga tttatcatgt gcaatatctc acacatctgt catttc                   946


<210>  2625
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  2625

Met Gln Leu Glu Lys Leu Val Val Leu Pro Gly Val Asp Trp Lys Cys 
1               5                   10                  15


Val Leu Pro Phe Lys Gln Ser Ser Ser Thr Cys Arg Thr Asp Gly Asn 
            20                  25                  30


Pro Leu Gly Lys Leu Ala Ser Asn Val Cys Leu His Ser Pro His Thr 
        35                  40                  45


Gly Phe Leu Thr Cys Asp Glu Gly Asn Phe Pro Gly Leu Val Trp Val 
    50                  55                  60


Cys Pro Gln Trp Thr Gly Ala Gln Asn Ala His Trp Arg Lys Trp Met 
65                  70                  75                  80


Glu Pro Arg Gly Cys His Ala Leu Cys Arg Gly Gly Ala Cys Ser Leu 
                85                  90                  95


Gln Leu Leu Trp 
            100


<210>  2626
<211>  1086
<212>  DNA
<213>  Homo sapiens

<400>  2626
cacagtccac atacagggtt cttaacctgc gtttttacct acattttaga ctgaccctgc     60

ttgtgcctgt gaaccaacca acaatctctg gctgcagctc agaaaggaca aaagagaatg    120

gatgagggaa acttcccagg gcttgtctgg gtatgcccac agtggactgg agcccaaaat    180

gcacactgga ggaagtggat ggagccacgt ggatgtcatg ccttatgcag gggaggagcc    240

tgctctcttc agctcctgtg gtaatgtggg aatcgatctg tgaggaaaca ctttctgaaa    300

atgtcagaac tcttgaaaac atggatgagg aaaagcataa gtactgcttt atgcttttct    360

tatgaatttt aaaagatgta atttaaaggt actttaaagt gatatttgtg cccttgtaac    420

tgattcaaag tagactgcta aggacaataa gtaataagag tctacaaata tcagtaaatt    480

atgagaaaaa acggtctaat ggtacttaaa attgcattgt gatttattaa ataacattga    540

acagctccac ctgtaacatt aagattccat ttgagcatat agaaaatata tttatcgcaa    600

cctgaagtga tttggaaagt atgctgggaa gaaaatatat ttacaaatta gtctcagagg    660

gtaggtatcc tgtagccaga tggaataaga agagagggaa gggagatttt gttcaaaggg    720

ggagcataag ctaaggaata aagccacaaa caatgattaa attaggtaaa gtgcaattag    780

ctgaatattg cataagcata catatgggaa gaagtggaaa aaggagtgac aatatgaagc    840

taaagggttt gaagtgttca agataatact aggcttccta gcctattccg agacatcttg    900

ttttagagtg caatagataa gaactctaag gatgaaagta ggagacatgc attctagtct    960

acgttttggt taatggactg aaagtgaaag atggactgaa attgggggat ggaataaaaa   1020

tgtgatagaa tagaaaatag aaaaagcaat tagcctaatg tcattgatac ttagagaaaa   1080

tatgga                                                              1086


<210>  2627
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  2627

Met Pro Thr Val Asp Trp Ser Pro Lys Cys Thr Leu Glu Glu Val Asp 
1               5                   10                  15


Gly Ala Thr Trp Met Ser Cys Leu Met Gln Gly Arg Ser Leu Leu Ser 
            20                  25                  30


Ser Ala Pro Val Val Met Trp Glu Ser Ile Cys Glu Glu Thr Leu Ser 
        35                  40                  45


Glu Asn Val Arg Thr Leu Glu Asn Met Asp Glu Glu Lys His Lys Tyr 
    50                  55                  60


Cys Phe Met Leu Phe Leu 
65                  70


<210>  2628
<211>  1194
<212>  DNA
<213>  Homo sapiens

<400>  2628
tctggaaaca ggactcttct aaaaagcatg taagggaact tgaagcagca tctcaatttg     60

tgcaatatga taaagaaaaa aaactgtggg atccagaaaa caatacacaa ttacttttat    120

ttatggctac cagaacttca ggaaaccgac taatgtttgt gcacataatg tttttattat    180

ggatctatct ggggcatatt gaacatacag tgccctcaaa aatggtcagt tttactcatg    240

cccaatccca tatatttttt agggtaattt ttctggtcca gttaagttag accaggacat    300

tttcacttga caaatctgag taaacttctc tggaaaaaat tgtttttgac cattcgccta    360

gaatgaatct ctgggtaagg aagatgcata tagtcgtata atttactgta gttattttga    420

caccttttct taacgacaca ccacagattt attgctggat atttttttcc ttcctaagcc    480

acttgccata tagttctact cttctctagc tctagggagg cttcctcata cagactaggt    540

caacagattc cattccactg gctcgtggat gggtttggct accgagaagc agttaagaga    600

agatcagaat tatagggagc agggagtagg aaaaggtgaa gaatttattt tcctgcttcc    660

ctgctgatcc cctcccaggc tcctacatgt tggtcacatt tctctaccaa atggtagttc    720

ctgtggggtt cttgtaaatt caccttcctc tttccataga gacaaaagct ccctgctttc    780

attcaccttc gatagctggg actacaggcg tccgccacca tgcccgacta attttttgta    840

tttttagtag agacggggtt tcatcgtgtt agccagaatg gtctcgatct cctgacctcg    900

tgattcgcca gcctcggcct cccaaagtgc tgggattaca ggcgtgagcc accacgccca    960

gccgggtact gcaaacattt aaacatttta aacgttcctc gaagacaatt tttccttcca   1020

ggacaatgac tgatacacct tcttaagctt acaactgcaa ataagtctct gcctaacata   1080

gcatctctgc tatacagccg ggaatgtact cctactcaat gggatggcta cacaatgaaa   1140

tcaatgagtg actgcactta aaaaatgccc attacaatat gagctatgtc ttcc         1194


<210>  2629
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  2629

Met Ala Thr Arg Thr Ser Gly Asn Arg Leu Met Phe Val His Ile Met 
1               5                   10                  15


Phe Leu Leu Trp Ile Tyr Leu Gly His Ile Glu His Thr Val Pro Ser 
            20                  25                  30


Lys Met Val Ser Phe Thr His Ala Gln Ser His Ile Phe Phe Arg Val 
        35                  40                  45


Ile Phe Leu Val Gln Leu Ser 
    50                  55


<210>  2630
<211>  11705
<212>  DNA
<213>  Homo sapiens

<400>  2630
gcgggagcct cggccaagcc gcgagcaggt gtgaatgagc ccagggaagg acacacggcc     60

actgctggag ggatcctcca ttcctgtgtc atttgcatgg gtcctgctgt gaaatgaacc    120

tggcagggac ttgttagaca cttccttcct tccctcattg agcactccag tgccattgtt    180

ccacagttgt tctaattggg tcctagcttc ctcctgccaa ggcaaacagc atagtctcga    240

gtaggtgtcc ctaggctcat ctgccagcct gaacatgaac acaggcaaag ctgatgatgg    300

ccagggaccc caggggacgt ggggccctgt ggggtctggc ccccaggagc aagacctctg    360

atgatgctgg tgtctgggag tgagcaccat gcccatcacc caggacaatg ccgtgctgca    420

cctgcccctc ctctaccagt ggctgcagaa cagcctgcag gaaggtgggg atgggccgga    480

gcagcggctc tgccaggcgg ccatccagaa gctgcaggag tacatccagc tgaactttgc    540

tgtggatgag agtacggtcc cacctgatca cagccccccc gaaatggaga tctgtactgt    600

gtacctcacc aaggagctgg gggacacaga gactgtgggc ctgagttttg ggaacatccc    660

tgttttcggg gactatggtg aaaagcgcag ggggggcaag aagaggaaaa cccaccaggg    720

tcctgtgctg gatgtgggct gcatctgggt gacagagctg aggaagaaca gcccagcagg    780

gaagagtggg aaggtccgac tgcgggatga gatcctctca ctgaatgggc agctgatggt    840

tggagttgat gtcagtgggg ccagttacct ggctgagcag tgctggaatg gcggctttat    900

ctacctgatc atgctgcgtc gctttaagca caaagcccac tccacttata atggcaacag    960

tagcaacagc tctgaaccag gagaaacacc taccttggag ctgggtgacc gaactgcgaa   1020

aaaggggaaa cgaaccagaa agtttggggt catctccagg cctcctgcca acaaggcccc   1080

tgaagaatcc aagggcagcg ctggctgtga ggtgtccagt gaccccagca ctgagctgga   1140

gaacggccct gaccctgaac ttggaaacgg ccatgtcttt cagctagaaa atggcccaga   1200

ttctctcaag gaggtggctg gaccccatct agagaggtca gaagtggaca gagggacaga   1260

gcatagaatt ccaaagacag atgctcctct gaccacaagc aatgacaaac gccgcttctc   1320

aaaaggtggg aagacggact tccaatcgag tgactgcctg gcacgggagg aagttggccg   1380

aatatggaag atggagctgc tcaaagaatc ggatgggctg ggaattcagg ttagtggagg   1440

ccgaggatca aagcgctcac ctcacgctat cgttgtcact caagtgaagg aaggaggtgc   1500

cgctcacagg gatggcaggc tgtccttagg agatgagctg ctggtaatca atggtcattt   1560

actggtcggg ctctcccacg aggaagcagt ggccattctt cgctccgcca cgggaatggt   1620

gcagcttgtg gtggccagca aggaaaactc cgcagaggac ctcctcaggt taacatctaa   1680

gagcttgcca gatctgacca gctcggtaga agatgtgtcc tcctggactg ataacgaaga   1740

ccaggaggca gacggggaag aggacgaagg aaccagctct tctgtccaga gagcaatgcc   1800

tgggacagat gaaccccaag atgtgtgcgg tgctgaggaa tccaagggga acttggaaag   1860

tcccaaacag ggcagcaata aaatcaagct caagagtcgc ctttcagggg gtgtacaccg   1920

ccttgagtca gttgaagaat ataacgagct gatggtgcgg aatggggacc cccggatccg   1980

gatgttggag gtctcccgag atggccggaa acactccctc ccgcagctgc tggactcttc   2040

cagtgcctca caggaatacc acattgtgaa gaagtctacc cgctccttaa gcacgactca   2100

ggtggaatct ccttggaggc tcattcggcc atccgtcatc tcgatcattg ggttgtacaa   2160

agaaaaaggc aagggccttg gctttagtat tgctggaggt cgagactgca ttcgtggaca   2220

gatggggatt tttgtcaaga ccatcttccc aaatggatca gctgcagagg acggaagact   2280

taaagaaggg gatgaaatcc tagatgtaaa tggaatacca ataaagggct tgacatttca   2340

agaagccatt cataccttta agcaaatccg gagtggatta tttgttttaa cggtacgcac   2400

aaagttggtg agccccagcc tcacaccctg ctcgacaccc acacacatga gcagatccgc   2460

ctccccgaac ttcaatacca gtgggggagc ctcagcggga ggttccgatg aaggcagttc   2520

ttcatccctg ggtcggaaga cccctgggcc caaggacagg atcgtcatgg aagtaacact   2580

caacaaagag ccaagagttg gattaggcat tggtgcctgc tgcttggctc tggaaaacag   2640

tcctcctggc atctacattc acagccttgc tccaggatca gtggccaaga tggagagcaa   2700

cctgagccgc ggggatcaaa tcctggaagt gaactccgtc aacgtccgcc atgctgcttt   2760

aagcaaagtc cacgccatct tgagtaaatg ccctccagga cccgttcgcc ttgtcatcgg   2820

ccggcaccct aatccaaagg tttccgagca ggaaatggat gaagtcatag cacgcagcac   2880

ttatcaggag agcaaagagg ccaattcctc tcctggctta ggtaccccct tgaagagtcc   2940

ctctcttgca aaaaaggact cccttatttc tgaatctgaa ctctcccagt actttgccca   3000

cgatgtccct ggccccttgt cagacttcat ggtggccggt tctgaggacg aggatcaccc   3060

gggaagtggc tgcagcacgt cggaggaggg cagcctgcct cccagcacct ccactcacaa   3120

ggagcctgga aaacccagag ccaacagcct cgtgactctt gggagccatc gggcttctgg   3180

gctcttccac aagcaggtga cagttgccag acaagccagt ctccccggaa gcccacaggc   3240

cctccgaaac cctctcctcc gccagaggaa ggtaggctgc tacgatgcca acgatgccag   3300

tgatgaggaa gagtttgaca gagaagggga ctgcatttca ctcccagggg ccctcccggg   3360

tcccatcagg cctctgtcag aggatgaccc gaggcgtgtc tcaatttcct cttccaaggg   3420

catggacgtc cacaaccaag aggaacgacc ccggaaaaca ctggtgagca aggccatctc   3480

ggcacctctt cttggtagct cagtggactt agaggagagt atcccagagg gcatggtgga   3540

tgctgcgtcc tatgcagcca acctcacgga ctctgcagag gcccccaagg ggagccctgg   3600

aagctggtgg aagaaggaac tgtcaggatc aagtagcgca cccaaattgg aatacacagt   3660

ccgtacagac acccagagtc cgacgaacac tgggagcccc agttcccccc agcagaaaag   3720

tgaaggcctg ggctccaggc acagaccagt ggccagggta agcccccact gcaagagatc   3780

cgaggctgag gccaagccca gtggctcaca gacagtgaac ctgactggca gagccaatga   3840

tccatgcgat ctggactcga gagtccaggc cacttctgtc aaagtgactg tcgctggctt   3900

tcagccaggt ggagctgtgg agaaggaatc tctgggaaag ctgaccactg gagatgcttg   3960

tgtctctacc agctgtgaac tagccagtgc tctgtcccat ctggatgcca gccacctcac   4020

agagaacctg cccaaagctg catcagagct ggggcaacaa cccatgactg aactggacag   4080

ctcctcagac ctcatctctt ccccagggaa gaagggggcc gctcatcctg accccagcaa   4140

gacctctgta gacacagggc aagtcagtcg gccagagaat cccagccagc ctgcatcgcc   4200

cagggtcacc aagtgcaagg ccaggtctcc agtcaggctc ccccatgagg gcagcccctc   4260

cccgggggag aaagcagcgg ctccccctga ctacagcaag actcgatcag catcggaaac   4320

cagcacaccc cacaatacca ggagggtggc tgccctcagg ggagcgggac ctggagcaga   4380

gggaatgaca ccagctggtg ctgtcctgcc aggagacccc ctcacatccc aggagcagag   4440

acagggagct ccaggtaacc acagtaaggc tctggaaatg acaggaatcc atgcacctga   4500

aagctcccag gagccttccc tgctggaggg agcagattct gtgtcctcaa gggcaccgca   4560

ggccagcctc tccatgctgc catccactga caacaccaaa gaagcatgtg gccatgtctc   4620

ggggcactgc tgcccagggg ggagtagaga gagccctgtg acggacattg acagcttcat   4680

caaggagctg gatgcttctg cagcaaggtc tccgtcttcc cagacggggg acagtggctc   4740

tcaggagggc agtgctcagg gccacccacc agccggggct ggaggtggga gctcctgccg   4800

tgccgaacca gtcccggggg gccagacctc ctccccgagg agggcctggg ctgctggtgc   4860

ccccgcctac ccacaatggg cctcccagcc ttcggtttta gattcaatta atcccgacaa   4920

acattttact gtgaacaaaa actttctgag caactactct agaaatttta gcagttttca   4980

tgaagacagc acctccctat caggcctggg tgacagcacg gagccgtctc tgtcatccat   5040

gtatggcgat gctgaggatt cttcttctga ccctgagtca ctcactgaag ccccacgagc   5100

ttctgccagg gacggctggt cccctcctcg ttcccgtgtg tctttgcaca aggaagatcc   5160

ttcggagtca gaagaggaac agattgagat ttgttccaca cgtggctgcc ccaatccacc   5220

ctcgagtcct gctcatcttc ccacccaggc tgccatctgt cctgcctcag ccaaagttct   5280

gtcattaaaa tacagcactc cgagagagtc ggtggccagt ccccgtgaga aggccgcctg   5340

cttgccaggc tcatacactt caggcccaga ctcttcccag ccatcatcac tcttggagat   5400

gagctctcag gagcatgaaa ctcatgcgga cataagcact tcacagaacc acaggccctc   5460

gtgtgcagaa gaaaccacag aagtcaccag cgctagctca gccatggaaa acagtccgct   5520

gtctaaagta gccaggcatt ttcacagtcc gcccatcatt ctcagctccc ccaacatggt   5580

aaatggcttg gaacatgacc tgctagatga cgaaaccctg aatcaatacg aaacaagcat   5640

taatgcagct gccagtctgt cctccttcag tgtggatgtc cctaagaatg gagaatctgt   5700

tttggaaaac ctccacatct ctgaaagtca agacctggat gacttgctac agaaaccaaa   5760

aatgatcgct aggaggccca tcatggcctg gtttaaagaa ataaataaac ataaccaagg   5820

cacacatttg aggagcaaaa ccgagaagga acaacctcta atgcctgcca gaagtcccga   5880

ctccaagatt cagatggtga gttcaagcca aaaaaagggc gttactgtgc ctcatagccc   5940

tcctcagccg aaaacaaacc tggaaaataa ggacctgtct aagaagagtc cggcagaaat   6000

gcttctgact aatggtcaga aggcaaagtg tggtccgaag ctgaagaggc tcagcctcaa   6060

gggcaaggcc aaagtcaact ctgaggcccc tgctgcgaat gctgtgaagg ctggggggac   6120

ggaccacagg aaacccttga tctcacccca gacctcccac aaaacacttt ctaaggcagt   6180

gtcacagcgg ctccatgtag ccgaccacga ggaccctgac agaaacacca cagctgcccc   6240

caggtccccc cagtgtgtgc tggaaagcaa gccacctctt gccacctctg ggccactgaa   6300

accctcagtg tctgacacga gcatcaggac atttgtctcg cccctgacct ctcccaagcc   6360

tgttcctgag caaggcatgt ggagcaggtt ccacatggct gtcctctctg aacccgacag   6420

aggttgccca accaccccta aatctcctaa gtgtagagca gagggcaggg cgccccgtgc   6480

tgactccggg ccggtgagtc cggcagcgtc taggaacggc atgtccgtgg cagggaacag   6540

acagagtgag ccgcgcctgg ccagccatgt ggcagcagac acagcccaac ccaggccgac   6600

tggcgaaaaa ggaggcaaca taatggccag cgatcgcctc gaaagaacaa accagctgaa   6660

aatcgtggag atttctgctg aagcagtgtc agagactgta tgtggtaaca agccagctga   6720

aagcgacaga cggggagggt gcttggccca gggcaactgt caggagaaga gtgaaatcag   6780

gctctatcgc caggtcgcag aatcatccac aagtcatcca tcctcactcc catctcatgc   6840

ctcccaggca gagcaggaaa tgtcacgatc attcagcatg gcaaaactgg cgtcctcctc   6900

ctcctccctt caaacagcca ttagaaaggc agaatactcc cagggaaaat caagcctgat   6960

gtcagactcc cgaggggtgc ccagaaacag cattccaggg ggcccctcgg gggaggacca   7020

tctctacttc accccaaggc cagcgaccag gacctactcc atgccagccc agttctcaag   7080

ccattttgga cgggagggtc accccccaca cagcctgggt cgctctcggg acagccaggt   7140

ccctgtgaca agcagtgttg tccccgaggc aaaggcatcc agaggtggtc ttcccagcct   7200

ggctaatgga cagggcatat atagtgtaaa gccgctgctg gacacatcga ggaatcttcc   7260

agccacagat gaaggggata tcatttcagt ccaggagacg agctgcctag tcacagacaa   7320

aatcaaagtc accagacgac actactgcta tgagcagaac tggccccatg aatctacctc   7380

atttttctct gtgaagcagc ggatcaagtc ttttgagaac ctggccaatg ctgaccggcc   7440

tgtagccaag tccggggctt ccccattttt gtcggtgagc tccaagcctc ccattgggag   7500

gcggtcttcc ggcagcattg tttccgggag cctgggccac ccaggtgacg cagcagcaag   7560

gttgttgaga cgcagcttga gttcctgcag cgaaaaccaa agcgaagccg gcaccctcct   7620

gccccagatg gccaagtctc cctcaatcat gacactgacc atctctcggc agaacccacc   7680

agagaccagt agcaagggct ctgattcgga actaaagaaa tcacttggtc ctttgggaat   7740

tcccacccca acgatgaccc tggcttctcc tgttaagagg aacaagtcct cggtacgcca   7800

cacgcagccc tcgcccgtgt cccgctccaa gctccaggag ctgagagcct tgagcatgcc   7860

tgaccttgac aagctctgca gcgaggatta ctcagcaggg ccgagcgccg tgctcttcaa   7920

aactgagctg gagatcaccc ccaggaggtc acctggccct cctgctggag gcgtttcgtg   7980

tcccgagaag ggcgggaaca gggcctgtcc aggaggaagt ggccctaaaa ccagtgctgc   8040

tgagacaccc agttcagcca gtgatacggg tgaagctgcc caggatctgc cttttagaag   8100

aagctggtca gttaatttgg atcaacttct agtctcagcg ggggaccagc aaagattaca   8160

gtctgtttta tcgtcagtgg gatcgaaatc taccatccta actctcattc aggaagcgaa   8220

agcacaatca gagaatgaag aagatgtttg cttcatagtc ttgaatagaa aagaaggctc   8280

aggtctggga ttcagtgtgg caggagggac agatgtggag ccaaaatcaa tcacggtcca   8340

cagggtgttt tctcaggggg cggcttctca ggaagggact atgaaccgag gggatttcct   8400

tctgtcagtc aacggcgcct cactggctgg cttagcccac gggaatgtcc tgaaggttct   8460

gcaccaggca cagctgcaca aagatgccct cgtggtcatc aagaaaggga tggatcagcc   8520

caggccctct gcccggcagg agcctcccac agccaatggg aagggtttgc tgtccagaaa   8580

gaccatcccc ctggagcctg gcattgggag aagtgtggct gtacacgatg ctctgtgtgt   8640

tgaagtgctg aagacctcgg ctgggctggg actgagtctg gatgggggaa aatcatcggt   8700

gacgggagat gggcccttgg tcattaaaag agtgtacaaa ggtggtgcgg ctgaacaagc   8760

tggaataata gaagctggag atgaaattct tgctattaat gggaaacctc tggttgggct   8820

catgcacttt gatgcctgga atattatgaa gtctgtccca gaaggacctg tgcagttatt   8880

aattagaaag cataggaatt cttcatgaat tttaacaaga atcattttct cagttctctt   8940

ctttctttag caaatcagag tgacttcttt aaaccacagg ttgttgaaat ggccaacact   9000

ggtacagaca cggactataa aaatctccaa gcttgtgctt acacatgaag cctgacttaa   9060

ctgtatgtgc aacagcaatg aaattaactc cagaagcctt ccacctgcgt cacccaggcc   9120

gggagggttc cttcgttcca gtgcctgtcc cctaccttta tgttatgttt actgatgggg   9180

atacaagatg tgacacaccc ttctttattt gaaacaaaca aacatttagc tagacctttg   9240

cttccttctt gccagctctc ccaacatacc caatcctggt gatcagggaa ctaaaagtct   9300

gagggggaca caaatgtcac acctaagagg acaatcaatc attttgtatg attttgtaag   9360

taaatgacag aatgctttta ggcacattca atggaaggag gagatgtagg tctgtatatg   9420

ttaccctgaa aagagaataa gacttactta aaaaaatgaa ttatgacctg ttaggctgag   9480

ctcaggaatt gtccaaaaag gaaaaagcaa aataattaat tgagagtatt ttttagtgag   9540

tgtaatgtat aatgtacgta tgcaaagttc aactcaatag gttattgatc accatgaagt   9600

attgatcatt ttctatctca aaagtgtaag ccataaggct gttttacaga atagcacttc   9660

tgataagctg tattaaatag ccatgagctt cactgcttag agggagcaga aaggtcaaca   9720

tctaaaagca ccttacaact agtttttgaa cctgtcttga taagtgcttg aattcaagac   9780

tggtcagtcc aagagcagac aaaaatatca caagtcagtc agtcactggg tttccatttc   9840

tgaattttat gcactccaac catgaattta aactaaattt ttagaaatca agtatctttc   9900

taagtgtcct tggatttata gacaatgtat gtacaatcca aatagaggag cttaatggaa   9960

tccttttagg agactggttg gtttttttcc ctctttccca acatgtttaa gaaatgtaac  10020

attctaagta ttggatctct tttcttgacc tagtataatg acaactgcag tgacttaagt  10080

ttttgctgtt ttcgttttcc cgctttgcaa tttcctcctt ttgccaaaaa tgttttccta  10140

cagaagactg tcgtgactca cgctacttgg gaaactcact ctggccactc ctcctctggt  10200

ggcatgagct gcttcccagt agctattccg attggatatt ccgttcgtcg tcacatagct  10260

ggcttttctc tcctcatgat gtaccttatt ttcttaggta aataattcca aactctcatc  10320

gggtcataaa gaggaggaga aacagggtga gtcaaggtaa aggagcagaa atgtagttac  10380

aagccaggtc gtcttcagtg gcacaaacca acccgttgag ccctgacaac atgagtggag  10440

agtgcatttg ccatacctgt gtgcatgaca ctaagatttt atgttggaga tacttcttta  10500

aataacctac agcttgggtc tatggctgtg acccccagat tcatggaggg gctttagcca  10560

tcagctttgt acatcatcat ttttctgaat gaccaatccc actaaacatc tttgaagtcg  10620

gcctagagag gtccttcaga tgagagagaa atagctggct tgtctgagtc cagatttctc  10680

atcaactggc aatacaaagg aaaatatggt acaggagtta gttagaaagg tcttattgat  10740

tttacttcta cttttcacta cagttacagg tagaatactg taggaagtca gtgcaaggtg  10800

catgcttgat tgatagatat tgattgattg tttttcagtc tctggggtca gttttgtggt  10860

ttctgctttc ttgcctaaat caaagactat ttcaagtcaa caacactgaa aactgctttt  10920

cgcctccact cttacagctg tgcctaataa taattaatta ataaacgcac agccctatgt  10980

gaacagacag gaatttcttg tgcaatgtgg agcaaatgga atggtctcct tccgcaagtc  11040

tttttaatcc tcatatctgg agtacaaggg tagacctctg gcttaccaca tacactatgc  11100

taaagtcatc agccactgct actacatctt gccagaaggt ttccctcgcc aacaaacagt  11160

tgaaatttaa gggaagaagc aaaagctaaa ctgtctttga ccctaagata gatagaaagc  11220

tatttatttg tcttcagtgt tcaaggcatg actagtattt ctaattagcc taataaattc  11280

ccacactttc tgaagtgaac actaatggta ttgtcctact aaaactgtca ttgtttcttt  11340

ttttttaact ggtcagtcat tcacaataag ctatgagggt aaataaatat gtgttataac  11400

aagtaaaccg tagttgcaag aatataccat gaagattaaa gtaggctggg tttcatttcc  11460

atcttcccac acatctcatt gaatttgatg gttgacttaa ttggcaccat aactttgtat  11520

gatattatac attaaccttt atttatgtaa agtaaaatgc cttatatatt aaagagtaag  11580

tgcaataata tgaaatagcc tgtacatttt aaaaatgttg tcaccaagtt atataaatcc  11640

acatctctgt aaacaacctt ttttaagtaa ttttaaaaaa aataaacact ctgcttacta  11700

cttga                                                              11705


<210>  2631
<211>  2839
<212>  PRT
<213>  Homo sapiens

<400>  2631

Met Pro Ile Thr Gln Asp Asn Ala Val Leu His Leu Pro Leu Leu Tyr 
1               5                   10                  15


Gln Trp Leu Gln Asn Ser Leu Gln Glu Gly Gly Asp Gly Pro Glu Gln 
            20                  25                  30


Arg Leu Cys Gln Ala Ala Ile Gln Lys Leu Gln Glu Tyr Ile Gln Leu 
        35                  40                  45


Asn Phe Ala Val Asp Glu Ser Thr Val Pro Pro Asp His Ser Pro Pro 
    50                  55                  60


Glu Met Glu Ile Cys Thr Val Tyr Leu Thr Lys Glu Leu Gly Asp Thr 
65                  70                  75                  80


Glu Thr Val Gly Leu Ser Phe Gly Asn Ile Pro Val Phe Gly Asp Tyr 
                85                  90                  95


Gly Glu Lys Arg Arg Gly Gly Lys Lys Arg Lys Thr His Gln Gly Pro 
            100                 105                 110


Val Leu Asp Val Gly Cys Ile Trp Val Thr Glu Leu Arg Lys Asn Ser 
        115                 120                 125


Pro Ala Gly Lys Ser Gly Lys Val Arg Leu Arg Asp Glu Ile Leu Ser 
    130                 135                 140


Leu Asn Gly Gln Leu Met Val Gly Val Asp Val Ser Gly Ala Ser Tyr 
145                 150                 155                 160


Leu Ala Glu Gln Cys Trp Asn Gly Gly Phe Ile Tyr Leu Ile Met Leu 
                165                 170                 175


Arg Arg Phe Lys His Lys Ala His Ser Thr Tyr Asn Gly Asn Ser Ser 
            180                 185                 190


Asn Ser Ser Glu Pro Gly Glu Thr Pro Thr Leu Glu Leu Gly Asp Arg 
        195                 200                 205


Thr Ala Lys Lys Gly Lys Arg Thr Arg Lys Phe Gly Val Ile Ser Arg 
    210                 215                 220


Pro Pro Ala Asn Lys Ala Pro Glu Glu Ser Lys Gly Ser Ala Gly Cys 
225                 230                 235                 240


Glu Val Ser Ser Asp Pro Ser Thr Glu Leu Glu Asn Gly Pro Asp Pro 
                245                 250                 255


Glu Leu Gly Asn Gly His Val Phe Gln Leu Glu Asn Gly Pro Asp Ser 
            260                 265                 270


Leu Lys Glu Val Ala Gly Pro His Leu Glu Arg Ser Glu Val Asp Arg 
        275                 280                 285


Gly Thr Glu His Arg Ile Pro Lys Thr Asp Ala Pro Leu Thr Thr Ser 
    290                 295                 300


Asn Asp Lys Arg Arg Phe Ser Lys Gly Gly Lys Thr Asp Phe Gln Ser 
305                 310                 315                 320


Ser Asp Cys Leu Ala Arg Glu Glu Val Gly Arg Ile Trp Lys Met Glu 
                325                 330                 335


Leu Leu Lys Glu Ser Asp Gly Leu Gly Ile Gln Val Ser Gly Gly Arg 
            340                 345                 350


Gly Ser Lys Arg Ser Pro His Ala Ile Val Val Thr Gln Val Lys Glu 
        355                 360                 365


Gly Gly Ala Ala His Arg Asp Gly Arg Leu Ser Leu Gly Asp Glu Leu 
    370                 375                 380


Leu Val Ile Asn Gly His Leu Leu Val Gly Leu Ser His Glu Glu Ala 
385                 390                 395                 400


Val Ala Ile Leu Arg Ser Ala Thr Gly Met Val Gln Leu Val Val Ala 
                405                 410                 415


Ser Lys Glu Asn Ser Ala Glu Asp Leu Leu Arg Leu Thr Ser Lys Ser 
            420                 425                 430


Leu Pro Asp Leu Thr Ser Ser Val Glu Asp Val Ser Ser Trp Thr Asp 
        435                 440                 445


Asn Glu Asp Gln Glu Ala Asp Gly Glu Glu Asp Glu Gly Thr Ser Ser 
    450                 455                 460


Ser Val Gln Arg Ala Met Pro Gly Thr Asp Glu Pro Gln Asp Val Cys 
465                 470                 475                 480


Gly Ala Glu Glu Ser Lys Gly Asn Leu Glu Ser Pro Lys Gln Gly Ser 
                485                 490                 495


Asn Lys Ile Lys Leu Lys Ser Arg Leu Ser Gly Gly Val His Arg Leu 
            500                 505                 510


Glu Ser Val Glu Glu Tyr Asn Glu Leu Met Val Arg Asn Gly Asp Pro 
        515                 520                 525


Arg Ile Arg Met Leu Glu Val Ser Arg Asp Gly Arg Lys His Ser Leu 
    530                 535                 540


Pro Gln Leu Leu Asp Ser Ser Ser Ala Ser Gln Glu Tyr His Ile Val 
545                 550                 555                 560


Lys Lys Ser Thr Arg Ser Leu Ser Thr Thr Gln Val Glu Ser Pro Trp 
                565                 570                 575


Arg Leu Ile Arg Pro Ser Val Ile Ser Ile Ile Gly Leu Tyr Lys Glu 
            580                 585                 590


Lys Gly Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly Arg Asp Cys Ile 
        595                 600                 605


Arg Gly Gln Met Gly Ile Phe Val Lys Thr Ile Phe Pro Asn Gly Ser 
    610                 615                 620


Ala Ala Glu Asp Gly Arg Leu Lys Glu Gly Asp Glu Ile Leu Asp Val 
625                 630                 635                 640


Asn Gly Ile Pro Ile Lys Gly Leu Thr Phe Gln Glu Ala Ile His Thr 
                645                 650                 655


Phe Lys Gln Ile Arg Ser Gly Leu Phe Val Leu Thr Val Arg Thr Lys 
            660                 665                 670


Leu Val Ser Pro Ser Leu Thr Pro Cys Ser Thr Pro Thr His Met Ser 
        675                 680                 685


Arg Ser Ala Ser Pro Asn Phe Asn Thr Ser Gly Gly Ala Ser Ala Gly 
    690                 695                 700


Gly Ser Asp Glu Gly Ser Ser Ser Ser Leu Gly Arg Lys Thr Pro Gly 
705                 710                 715                 720


Pro Lys Asp Arg Ile Val Met Glu Val Thr Leu Asn Lys Glu Pro Arg 
                725                 730                 735


Val Gly Leu Gly Ile Gly Ala Cys Cys Leu Ala Leu Glu Asn Ser Pro 
            740                 745                 750


Pro Gly Ile Tyr Ile His Ser Leu Ala Pro Gly Ser Val Ala Lys Met 
        755                 760                 765


Glu Ser Asn Leu Ser Arg Gly Asp Gln Ile Leu Glu Val Asn Ser Val 
    770                 775                 780


Asn Val Arg His Ala Ala Leu Ser Lys Val His Ala Ile Leu Ser Lys 
785                 790                 795                 800


Cys Pro Pro Gly Pro Val Arg Leu Val Ile Gly Arg His Pro Asn Pro 
                805                 810                 815


Lys Val Ser Glu Gln Glu Met Asp Glu Val Ile Ala Arg Ser Thr Tyr 
            820                 825                 830


Gln Glu Ser Lys Glu Ala Asn Ser Ser Pro Gly Leu Gly Thr Pro Leu 
        835                 840                 845


Lys Ser Pro Ser Leu Ala Lys Lys Asp Ser Leu Ile Ser Glu Ser Glu 
    850                 855                 860


Leu Ser Gln Tyr Phe Ala His Asp Val Pro Gly Pro Leu Ser Asp Phe 
865                 870                 875                 880


Met Val Ala Gly Ser Glu Asp Glu Asp His Pro Gly Ser Gly Cys Ser 
                885                 890                 895


Thr Ser Glu Glu Gly Ser Leu Pro Pro Ser Thr Ser Thr His Lys Glu 
            900                 905                 910


Pro Gly Lys Pro Arg Ala Asn Ser Leu Val Thr Leu Gly Ser His Arg 
        915                 920                 925


Ala Ser Gly Leu Phe His Lys Gln Val Thr Val Ala Arg Gln Ala Ser 
    930                 935                 940


Leu Pro Gly Ser Pro Gln Ala Leu Arg Asn Pro Leu Leu Arg Gln Arg 
945                 950                 955                 960


Lys Val Gly Cys Tyr Asp Ala Asn Asp Ala Ser Asp Glu Glu Glu Phe 
                965                 970                 975


Asp Arg Glu Gly Asp Cys Ile Ser Leu Pro Gly Ala Leu Pro Gly Pro 
            980                 985                 990


Ile Arg Pro Leu Ser Glu Asp Asp Pro Arg Arg Val Ser Ile Ser Ser 
        995                 1000                1005


Ser Lys Gly Met Asp Val His Asn Gln Glu Glu Arg Pro Arg Lys Thr 
    1010                1015                1020


Leu Val Ser Lys Ala Ile Ser Ala Pro Leu Leu Gly Ser Ser Val Asp 
1025                1030                1035                1040


Leu Glu Glu Ser Ile Pro Glu Gly Met Val Asp Ala Ala Ser Tyr Ala 
                1045                1050                1055


Ala Asn Leu Thr Asp Ser Ala Glu Ala Pro Lys Gly Ser Pro Gly Ser 
            1060                1065                1070


Trp Trp Lys Lys Glu Leu Ser Gly Ser Ser Ser Ala Pro Lys Leu Glu 
        1075                1080                1085


Tyr Thr Val Arg Thr Asp Thr Gln Ser Pro Thr Asn Thr Gly Ser Pro 
    1090                1095                1100


Ser Ser Pro Gln Gln Lys Ser Glu Gly Leu Gly Ser Arg His Arg Pro 
1105                1110                1115                1120


Val Ala Arg Val Ser Pro His Cys Lys Arg Ser Glu Ala Glu Ala Lys 
                1125                1130                1135


Pro Ser Gly Ser Gln Thr Val Asn Leu Thr Gly Arg Ala Asn Asp Pro 
            1140                1145                1150


Cys Asp Leu Asp Ser Arg Val Gln Ala Thr Ser Val Lys Val Thr Val 
        1155                1160                1165


Ala Gly Phe Gln Pro Gly Gly Ala Val Glu Lys Glu Ser Leu Gly Lys 
    1170                1175                1180


Leu Thr Thr Gly Asp Ala Cys Val Ser Thr Ser Cys Glu Leu Ala Ser 
1185                1190                1195                1200


Ala Leu Ser His Leu Asp Ala Ser His Leu Thr Glu Asn Leu Pro Lys 
                1205                1210                1215


Ala Ala Ser Glu Leu Gly Gln Gln Pro Met Thr Glu Leu Asp Ser Ser 
            1220                1225                1230


Ser Asp Leu Ile Ser Ser Pro Gly Lys Lys Gly Ala Ala His Pro Asp 
        1235                1240                1245


Pro Ser Lys Thr Ser Val Asp Thr Gly Gln Val Ser Arg Pro Glu Asn 
    1250                1255                1260


Pro Ser Gln Pro Ala Ser Pro Arg Val Thr Lys Cys Lys Ala Arg Ser 
1265                1270                1275                1280


Pro Val Arg Leu Pro His Glu Gly Ser Pro Ser Pro Gly Glu Lys Ala 
                1285                1290                1295


Ala Ala Pro Pro Asp Tyr Ser Lys Thr Arg Ser Ala Ser Glu Thr Ser 
            1300                1305                1310


Thr Pro His Asn Thr Arg Arg Val Ala Ala Leu Arg Gly Ala Gly Pro 
        1315                1320                1325


Gly Ala Glu Gly Met Thr Pro Ala Gly Ala Val Leu Pro Gly Asp Pro 
    1330                1335                1340


Leu Thr Ser Gln Glu Gln Arg Gln Gly Ala Pro Gly Asn His Ser Lys 
1345                1350                1355                1360


Ala Leu Glu Met Thr Gly Ile His Ala Pro Glu Ser Ser Gln Glu Pro 
                1365                1370                1375


Ser Leu Leu Glu Gly Ala Asp Ser Val Ser Ser Arg Ala Pro Gln Ala 
            1380                1385                1390


Ser Leu Ser Met Leu Pro Ser Thr Asp Asn Thr Lys Glu Ala Cys Gly 
        1395                1400                1405


His Val Ser Gly His Cys Cys Pro Gly Gly Ser Arg Glu Ser Pro Val 
    1410                1415                1420


Thr Asp Ile Asp Ser Phe Ile Lys Glu Leu Asp Ala Ser Ala Ala Arg 
1425                1430                1435                1440


Ser Pro Ser Ser Gln Thr Gly Asp Ser Gly Ser Gln Glu Gly Ser Ala 
                1445                1450                1455


Gln Gly His Pro Pro Ala Gly Ala Gly Gly Gly Ser Ser Cys Arg Ala 
            1460                1465                1470


Glu Pro Val Pro Gly Gly Gln Thr Ser Ser Pro Arg Arg Ala Trp Ala 
        1475                1480                1485


Ala Gly Ala Pro Ala Tyr Pro Gln Trp Ala Ser Gln Pro Ser Val Leu 
    1490                1495                1500


Asp Ser Ile Asn Pro Asp Lys His Phe Thr Val Asn Lys Asn Phe Leu 
1505                1510                1515                1520


Ser Asn Tyr Ser Arg Asn Phe Ser Ser Phe His Glu Asp Ser Thr Ser 
                1525                1530                1535


Leu Ser Gly Leu Gly Asp Ser Thr Glu Pro Ser Leu Ser Ser Met Tyr 
            1540                1545                1550


Gly Asp Ala Glu Asp Ser Ser Ser Asp Pro Glu Ser Leu Thr Glu Ala 
        1555                1560                1565


Pro Arg Ala Ser Ala Arg Asp Gly Trp Ser Pro Pro Arg Ser Arg Val 
    1570                1575                1580


Ser Leu His Lys Glu Asp Pro Ser Glu Ser Glu Glu Glu Gln Ile Glu 
1585                1590                1595                1600


Ile Cys Ser Thr Arg Gly Cys Pro Asn Pro Pro Ser Ser Pro Ala His 
                1605                1610                1615


Leu Pro Thr Gln Ala Ala Ile Cys Pro Ala Ser Ala Lys Val Leu Ser 
            1620                1625                1630


Leu Lys Tyr Ser Thr Pro Arg Glu Ser Val Ala Ser Pro Arg Glu Lys 
        1635                1640                1645


Ala Ala Cys Leu Pro Gly Ser Tyr Thr Ser Gly Pro Asp Ser Ser Gln 
    1650                1655                1660


Pro Ser Ser Leu Leu Glu Met Ser Ser Gln Glu His Glu Thr His Ala 
1665                1670                1675                1680


Asp Ile Ser Thr Ser Gln Asn His Arg Pro Ser Cys Ala Glu Glu Thr 
                1685                1690                1695


Thr Glu Val Thr Ser Ala Ser Ser Ala Met Glu Asn Ser Pro Leu Ser 
            1700                1705                1710


Lys Val Ala Arg His Phe His Ser Pro Pro Ile Ile Leu Ser Ser Pro 
        1715                1720                1725


Asn Met Val Asn Gly Leu Glu His Asp Leu Leu Asp Asp Glu Thr Leu 
    1730                1735                1740


Asn Gln Tyr Glu Thr Ser Ile Asn Ala Ala Ala Ser Leu Ser Ser Phe 
1745                1750                1755                1760


Ser Val Asp Val Pro Lys Asn Gly Glu Ser Val Leu Glu Asn Leu His 
                1765                1770                1775


Ile Ser Glu Ser Gln Asp Leu Asp Asp Leu Leu Gln Lys Pro Lys Met 
            1780                1785                1790


Ile Ala Arg Arg Pro Ile Met Ala Trp Phe Lys Glu Ile Asn Lys His 
        1795                1800                1805


Asn Gln Gly Thr His Leu Arg Ser Lys Thr Glu Lys Glu Gln Pro Leu 
    1810                1815                1820


Met Pro Ala Arg Ser Pro Asp Ser Lys Ile Gln Met Val Ser Ser Ser 
1825                1830                1835                1840


Gln Lys Lys Gly Val Thr Val Pro His Ser Pro Pro Gln Pro Lys Thr 
                1845                1850                1855


Asn Leu Glu Asn Lys Asp Leu Ser Lys Lys Ser Pro Ala Glu Met Leu 
            1860                1865                1870


Leu Thr Asn Gly Gln Lys Ala Lys Cys Gly Pro Lys Leu Lys Arg Leu 
        1875                1880                1885


Ser Leu Lys Gly Lys Ala Lys Val Asn Ser Glu Ala Pro Ala Ala Asn 
    1890                1895                1900


Ala Val Lys Ala Gly Gly Thr Asp His Arg Lys Pro Leu Ile Ser Pro 
1905                1910                1915                1920


Gln Thr Ser His Lys Thr Leu Ser Lys Ala Val Ser Gln Arg Leu His 
                1925                1930                1935


Val Ala Asp His Glu Asp Pro Asp Arg Asn Thr Thr Ala Ala Pro Arg 
            1940                1945                1950


Ser Pro Gln Cys Val Leu Glu Ser Lys Pro Pro Leu Ala Thr Ser Gly 
        1955                1960                1965


Pro Leu Lys Pro Ser Val Ser Asp Thr Ser Ile Arg Thr Phe Val Ser 
    1970                1975                1980


Pro Leu Thr Ser Pro Lys Pro Val Pro Glu Gln Gly Met Trp Ser Arg 
1985                1990                1995                2000


Phe His Met Ala Val Leu Ser Glu Pro Asp Arg Gly Cys Pro Thr Thr 
                2005                2010                2015


Pro Lys Ser Pro Lys Cys Arg Ala Glu Gly Arg Ala Pro Arg Ala Asp 
            2020                2025                2030


Ser Gly Pro Val Ser Pro Ala Ala Ser Arg Asn Gly Met Ser Val Ala 
        2035                2040                2045


Gly Asn Arg Gln Ser Glu Pro Arg Leu Ala Ser His Val Ala Ala Asp 
    2050                2055                2060


Thr Ala Gln Pro Arg Pro Thr Gly Glu Lys Gly Gly Asn Ile Met Ala 
2065                2070                2075                2080


Ser Asp Arg Leu Glu Arg Thr Asn Gln Leu Lys Ile Val Glu Ile Ser 
                2085                2090                2095


Ala Glu Ala Val Ser Glu Thr Val Cys Gly Asn Lys Pro Ala Glu Ser 
            2100                2105                2110


Asp Arg Arg Gly Gly Cys Leu Ala Gln Gly Asn Cys Gln Glu Lys Ser 
        2115                2120                2125


Glu Ile Arg Leu Tyr Arg Gln Val Ala Glu Ser Ser Thr Ser His Pro 
    2130                2135                2140


Ser Ser Leu Pro Ser His Ala Ser Gln Ala Glu Gln Glu Met Ser Arg 
2145                2150                2155                2160


Ser Phe Ser Met Ala Lys Leu Ala Ser Ser Ser Ser Ser Leu Gln Thr 
                2165                2170                2175


Ala Ile Arg Lys Ala Glu Tyr Ser Gln Gly Lys Ser Ser Leu Met Ser 
            2180                2185                2190


Asp Ser Arg Gly Val Pro Arg Asn Ser Ile Pro Gly Gly Pro Ser Gly 
        2195                2200                2205


Glu Asp His Leu Tyr Phe Thr Pro Arg Pro Ala Thr Arg Thr Tyr Ser 
    2210                2215                2220


Met Pro Ala Gln Phe Ser Ser His Phe Gly Arg Glu Gly His Pro Pro 
2225                2230                2235                2240


His Ser Leu Gly Arg Ser Arg Asp Ser Gln Val Pro Val Thr Ser Ser 
                2245                2250                2255


Val Val Pro Glu Ala Lys Ala Ser Arg Gly Gly Leu Pro Ser Leu Ala 
            2260                2265                2270


Asn Gly Gln Gly Ile Tyr Ser Val Lys Pro Leu Leu Asp Thr Ser Arg 
        2275                2280                2285


Asn Leu Pro Ala Thr Asp Glu Gly Asp Ile Ile Ser Val Gln Glu Thr 
    2290                2295                2300


Ser Cys Leu Val Thr Asp Lys Ile Lys Val Thr Arg Arg His Tyr Cys 
2305                2310                2315                2320


Tyr Glu Gln Asn Trp Pro His Glu Ser Thr Ser Phe Phe Ser Val Lys 
                2325                2330                2335


Gln Arg Ile Lys Ser Phe Glu Asn Leu Ala Asn Ala Asp Arg Pro Val 
            2340                2345                2350


Ala Lys Ser Gly Ala Ser Pro Phe Leu Ser Val Ser Ser Lys Pro Pro 
        2355                2360                2365


Ile Gly Arg Arg Ser Ser Gly Ser Ile Val Ser Gly Ser Leu Gly His 
    2370                2375                2380


Pro Gly Asp Ala Ala Ala Arg Leu Leu Arg Arg Ser Leu Ser Ser Cys 
2385                2390                2395                2400


Ser Glu Asn Gln Ser Glu Ala Gly Thr Leu Leu Pro Gln Met Ala Lys 
                2405                2410                2415


Ser Pro Ser Ile Met Thr Leu Thr Ile Ser Arg Gln Asn Pro Pro Glu 
            2420                2425                2430


Thr Ser Ser Lys Gly Ser Asp Ser Glu Leu Lys Lys Ser Leu Gly Pro 
        2435                2440                2445


Leu Gly Ile Pro Thr Pro Thr Met Thr Leu Ala Ser Pro Val Lys Arg 
    2450                2455                2460


Asn Lys Ser Ser Val Arg His Thr Gln Pro Ser Pro Val Ser Arg Ser 
2465                2470                2475                2480


Lys Leu Gln Glu Leu Arg Ala Leu Ser Met Pro Asp Leu Asp Lys Leu 
                2485                2490                2495


Cys Ser Glu Asp Tyr Ser Ala Gly Pro Ser Ala Val Leu Phe Lys Thr 
            2500                2505                2510


Glu Leu Glu Ile Thr Pro Arg Arg Ser Pro Gly Pro Pro Ala Gly Gly 
        2515                2520                2525


Val Ser Cys Pro Glu Lys Gly Gly Asn Arg Ala Cys Pro Gly Gly Ser 
    2530                2535                2540


Gly Pro Lys Thr Ser Ala Ala Glu Thr Pro Ser Ser Ala Ser Asp Thr 
2545                2550                2555                2560


Gly Glu Ala Ala Gln Asp Leu Pro Phe Arg Arg Ser Trp Ser Val Asn 
                2565                2570                2575


Leu Asp Gln Leu Leu Val Ser Ala Gly Asp Gln Gln Arg Leu Gln Ser 
            2580                2585                2590


Val Leu Ser Ser Val Gly Ser Lys Ser Thr Ile Leu Thr Leu Ile Gln 
        2595                2600                2605


Glu Ala Lys Ala Gln Ser Glu Asn Glu Glu Asp Val Cys Phe Ile Val 
    2610                2615                2620


Leu Asn Arg Lys Glu Gly Ser Gly Leu Gly Phe Ser Val Ala Gly Gly 
2625                2630                2635                2640


Thr Asp Val Glu Pro Lys Ser Ile Thr Val His Arg Val Phe Ser Gln 
                2645                2650                2655


Gly Ala Ala Ser Gln Glu Gly Thr Met Asn Arg Gly Asp Phe Leu Leu 
            2660                2665                2670


Ser Val Asn Gly Ala Ser Leu Ala Gly Leu Ala His Gly Asn Val Leu 
        2675                2680                2685


Lys Val Leu His Gln Ala Gln Leu His Lys Asp Ala Leu Val Val Ile 
    2690                2695                2700


Lys Lys Gly Met Asp Gln Pro Arg Pro Ser Ala Arg Gln Glu Pro Pro 
2705                2710                2715                2720


Thr Ala Asn Gly Lys Gly Leu Leu Ser Arg Lys Thr Ile Pro Leu Glu 
                2725                2730                2735


Pro Gly Ile Gly Arg Ser Val Ala Val His Asp Ala Leu Cys Val Glu 
            2740                2745                2750


Val Leu Lys Thr Ser Ala Gly Leu Gly Leu Ser Leu Asp Gly Gly Lys 
        2755                2760                2765


Ser Ser Val Thr Gly Asp Gly Pro Leu Val Ile Lys Arg Val Tyr Lys 
    2770                2775                2780


Gly Gly Ala Ala Glu Gln Ala Gly Ile Ile Glu Ala Gly Asp Glu Ile 
2785                2790                2795                2800


Leu Ala Ile Asn Gly Lys Pro Leu Val Gly Leu Met His Phe Asp Ala 
                2805                2810                2815


Trp Asn Ile Met Lys Ser Val Pro Glu Gly Pro Val Gln Leu Leu Ile 
            2820                2825                2830


Arg Lys His Arg Asn Ser Ser 
        2835


<210>  2632
<211>  11765
<212>  DNA
<213>  Homo sapiens

<400>  2632
aatcggcgtc tttcccagac caccatgagg gccggcgttc ctgctcagct gtgaatgctg     60

ctgttgttat ggctgctgct tggcttaggt gtgaatgagc ccagggaagg acacacggcc    120

actgctggag ggatcctcca ttcctgtgtc atttgcatgg gtcctgctgt gaaatgaacc    180

tggcagggac ttgttagaca cttccttcct tccctcattg agcactccag tgccattgtt    240

ccacagttgt tctaattggg tcctagcttc ctcctgccaa ggcaaacagc atagtctcga    300

gtaggtgtcc ctaggctcat ctgccagcct gaacatgaac acaggcaaag ctgatgatgg    360

ccagggaccc caggggacgt ggggccctgt ggggtctggc ccccaggagc aagacctctg    420

atgatgctgg tgtctgggag tgagcaccat gcccatcacc caggacaatg ccgtgctgca    480

cctgcccctc ctctaccagt ggctgcagaa cagcctgcag gaaggtgggg atgggccgga    540

gcagcggctc tgccaggcgg ccatccagaa gctgcaggag tacatccagc tgaactttgc    600

tgtggatgag agtacggtcc cacctgatca cagccccccc gaaatggaga tctgtactgt    660

gtacctcacc aaggagctgg gggacacaga gactgtgggc ctgagttttg ggaacatccc    720

tgttttcggg gactatggtg aaaagcgcag ggggggcaag aagaggaaaa cccaccaggg    780

tcctgtgctg gatgtgggct gcatctgggt gacagagctg aggaagaaca gcccagcagg    840

gaagagtggg aaggtccgac tgcgggatga gatcctctca ctgaatgggc agctgatggt    900

tggagttgat gtcagtgggg ccagttacct ggctgagcag tgctggaatg gcggctttat    960

ctacctgatc atgctgcgtc gctttaagca caaagcccac tccacttata atggcaacag   1020

tagcaacagc tctgaaccag gagaaacacc taccttggag ctgggtgacc gaactgcgaa   1080

aaaggggaaa cgaaccagaa agtttggggt catctccagg cctcctgcca acaaggcccc   1140

tgaagaatcc aagggcagcg ctggctgtga ggtgtccagt gaccccagca ctgagctgga   1200

gaacggccct gaccctgaac ttggaaacgg ccatgtcttt cagctagaaa atggcccaga   1260

ttctctcaag gaggtggctg gaccccatct agagaggtca gaagtggaca gagggacaga   1320

gcatagaatt ccaaagacag atgctcctct gaccacaagc aatgacaaac gccgcttctc   1380

aaaaggtggg aagacggact tccaatcgag tgactgcctg gcacgggagg aagttggccg   1440

aatatggaag atggagctgc tcaaagaatc ggatgggctg ggaattcagg ttagtggagg   1500

ccgaggatca aagcgctcac ctcacgctat cgttgtcact caagtgaagg aaggaggtgc   1560

cgctcacagg gatggcaggc tgtccttagg agatgagctg ctggtaatca atggtcattt   1620

actggtcggg ctctcccacg aggaagcagt ggccattctt cgctccgcca cgggaatggt   1680

gcagcttgtg gtggccagca aggaaaactc cgcagaggac ctcctcaggt taacatctaa   1740

gagcttgcca gatctgacca gctcggtaga agatgtgtcc tcctggactg ataacgaaga   1800

ccaggaggca gacggggaag aggacgaagg aaccagctct tctgtccaga gagcaatgcc   1860

tgggacagat gaaccccaag atgtgtgcgg tgctgaggaa tccaagggga acttggaaag   1920

tcccaaacag ggcagcaata aaatcaagct caagagtcgc ctttcagggg gtgtacaccg   1980

ccttgagtca gttgaagaat ataacgagct gatggtgcgg aatggggacc cccggatccg   2040

gatgttggag gtctcccgag atggccggaa acactccctc ccgcagctgc tggactcttc   2100

cagtgcctca caggaatacc acattgtgaa gaagtctacc cgctccttaa gcacgactca   2160

ggtggaatct ccttggaggc tcattcggcc atccgtcatc tcgatcattg ggttgtacaa   2220

agaaaaaggc aagggccttg gctttagtat tgctggaggt cgagactgca ttcgtggaca   2280

gatggggatt tttgtcaaga ccatcttccc aaatggatca gctgcagagg acggaagact   2340

taaagaaggg gatgaaatcc tagatgtaaa tggaatacca ataaagggct tgacatttca   2400

agaagccatt cataccttta agcaaatccg gagtggatta tttgttttaa cggtacgcac   2460

aaagttggtg agccccagcc tcacaccctg ctcgacaccc acacacatga gcagatccgc   2520

ctccccgaac ttcaatacca gtgggggagc ctcagcggga ggttccgatg aaggcagttc   2580

ttcatccctg ggtcggaaga cccctgggcc caaggacagg atcgtcatgg aagtaacact   2640

caacaaagag ccaagagttg gattaggcat tggtgcctgc tgcttggctc tggaaaacag   2700

tcctcctggc atctacattc acagccttgc tccaggatca gtggccaaga tggagagcaa   2760

cctgagccgc ggggatcaaa tcctggaagt gaactccgtc aacgtccgcc atgctgcttt   2820

aagcaaagtc cacgccatct tgagtaaatg ccctccagga cccgttcgcc ttgtcatcgg   2880

ccggcaccct aatccaaagg tttccgagca ggaaatggat gaagtcatag cacgcagcac   2940

ttatcaggag agcaaagagg ccaattcctc tcctggctta ggtaccccct tgaagagtcc   3000

ctctcttgca aaaaaggact cccttatttc tgaatctgaa ctctcccagt actttgccca   3060

cgatgtccct ggccccttgt cagacttcat ggtggccggt tctgaggacg aggatcaccc   3120

gggaagtggc tgcagcacgt cggaggaggg cagcctgcct cccagcacct ccactcacaa   3180

ggagcctgga aaacccagag ccaacagcct cgtgactctt gggagccatc gggcttctgg   3240

gctcttccac aagcaggtga cagttgccag acaagccagt ctccccggaa gcccacaggc   3300

cctccgaaac cctctcctcc gccagaggaa ggtaggctgc tacgatgcca acgatgccag   3360

tgatgaggaa gagtttgaca gagaagggga ctgcatttca ctcccagggg ccctcccggg   3420

tcccatcagg cctctgtcag aggatgaccc gaggcgtgtc tcaatttcct cttccaaggg   3480

catggacgtc cacaaccaag aggaacgacc ccggaaaaca ctggtgagca aggccatctc   3540

ggcacctctt cttggtagct cagtggactt agaggagagt atcccagagg gcatggtgga   3600

tgctgcgtcc tatgcagcca acctcacgga ctctgcagag gcccccaagg ggagccctgg   3660

aagctggtgg aagaaggaac tgtcaggatc aagtagcgca cccaaattgg aatacacagt   3720

ccgtacagac acccagagtc cgacgaacac tgggagcccc agttcccccc agcagaaaag   3780

tgaaggcctg ggctccaggc acagaccagt ggccagggta agcccccact gcaagagatc   3840

cgaggctgag gccaagccca gtggctcaca gacagtgaac ctgactggca gagccaatga   3900

tccatgcgat ctggactcga gagtccaggc cacttctgtc aaagtgactg tcgctggctt   3960

tcagccaggt ggagctgtgg agaaggaatc tctgggaaag ctgaccactg gagatgcttg   4020

tgtctctacc agctgtgaac tagccagtgc tctgtcccat ctggatgcca gccacctcac   4080

agagaacctg cccaaagctg catcagagct ggggcaacaa cccatgactg aactggacag   4140

ctcctcagac ctcatctctt ccccagggaa gaagggggcc gctcatcctg accccagcaa   4200

gacctctgta gacacagggc aagtcagtcg gccagagaat cccagccagc ctgcatcgcc   4260

cagggtcacc aagtgcaagg ccaggtctcc agtcaggctc ccccatgagg gcagcccctc   4320

cccgggggag aaagcagcgg ctccccctga ctacagcaag actcgatcag catcggaaac   4380

cagcacaccc cacaatacca ggagggtggc tgccctcagg ggagcgggac ctggagcaga   4440

gggaatgaca ccagctggtg ctgtcctgcc aggagacccc ctcacatccc aggagcagag   4500

acagggagct ccaggtaacc acagtaaggc tctggaaatg acaggaatcc atgcacctga   4560

aagctcccag gagccttccc tgctggaggg agcagattct gtgtcctcaa gggcaccgca   4620

ggccagcctc tccatgctgc catccactga caacaccaaa gaagcatgtg gccatgtctc   4680

ggggcactgc tgcccagggg ggagtagaga gagccctgtg acggacattg acagcttcat   4740

caaggagctg gatgcttctg cagcaaggtc tccgtcttcc cagacggggg acagtggctc   4800

tcaggagggc agtgctcagg gccacccacc agccggggct ggaggtggga gctcctgccg   4860

tgccgaacca gtcccggggg gccagacctc ctccccgagg agggcctggg ctgctggtgc   4920

ccccgcctac ccacaatggg cctcccagcc ttcggtttta gattcaatta atcccgacaa   4980

acattttact gtgaacaaaa actttctgag caactactct agaaatttta gcagttttca   5040

tgaagacagc acctccctat caggcctggg tgacagcacg gagccgtctc tgtcatccat   5100

gtatggcgat gctgaggatt cttcttctga ccctgagtca ctcactgaag ccccacgagc   5160

ttctgccagg gacggctggt cccctcctcg ttcccgtgtg tctttgcaca aggaagatcc   5220

ttcggagtca gaagaggaac agattgagat ttgttccaca cgtggctgcc ccaatccacc   5280

ctcgagtcct gctcatcttc ccacccaggc tgccatctgt cctgcctcag ccaaagttct   5340

gtcattaaaa tacagcactc cgagagagtc ggtggccagt ccccgtgaga aggccgcctg   5400

cttgccaggc tcatacactt caggcccaga ctcttcccag ccatcatcac tcttggagat   5460

gagctctcag gagcatgaaa ctcatgcgga cataagcact tcacagaacc acaggccctc   5520

gtgtgcagaa gaaaccacag aagtcaccag cgctagctca gccatggaaa acagtccgct   5580

gtctaaagta gccaggcatt ttcacagtcc gcccatcatt ctcagctccc ccaacatggt   5640

aaatggcttg gaacatgacc tgctagatga cgaaaccctg aatcaatacg aaacaagcat   5700

taatgcagct gccagtctgt cctccttcag tgtggatgtc cctaagaatg gagaatctgt   5760

tttggaaaac ctccacatct ctgaaagtca agacctggat gacttgctac agaaaccaaa   5820

aatgatcgct aggaggccca tcatggcctg gtttaaagaa ataaataaac ataaccaagg   5880

cacacatttg aggagcaaaa ccgagaagga acaacctcta atgcctgcca gaagtcccga   5940

ctccaagatt cagatggtga gttcaagcca aaaaaagggc gttactgtgc ctcatagccc   6000

tcctcagccg aaaacaaacc tggaaaataa ggacctgtct aagaagagtc cggcagaaat   6060

gcttctgact aatggtcaga aggcaaagtg tggtccgaag ctgaagaggc tcagcctcaa   6120

gggcaaggcc aaagtcaact ctgaggcccc tgctgcgaat gctgtgaagg ctggggggac   6180

ggaccacagg aaacccttga tctcacccca gacctcccac aaaacacttt ctaaggcagt   6240

gtcacagcgg ctccatgtag ccgaccacga ggaccctgac agaaacacca cagctgcccc   6300

caggtccccc cagtgtgtgc tggaaagcaa gccacctctt gccacctctg ggccactgaa   6360

accctcagtg tctgacacga gcatcaggac atttgtctcg cccctgacct ctcccaagcc   6420

tgttcctgag caaggcatgt ggagcaggtt ccacatggct gtcctctctg aacccgacag   6480

aggttgccca accaccccta aatctcctaa gtgtagagca gagggcaggg cgccccgtgc   6540

tgactccggg ccggtgagtc cggcagcgtc taggaacggc atgtccgtgg cagggaacag   6600

acagagtgag ccgcgcctgg ccagccatgt ggcagcagac acagcccaac ccaggccgac   6660

tggcgaaaaa ggaggcaaca taatggccag cgatcgcctc gaaagaacaa accagctgaa   6720

aatcgtggag atttctgctg aagcagtgtc agagactgta tgtggtaaca agccagctga   6780

aagcgacaga cggggagggt gcttggccca gggcaactgt caggagaaga gtgaaatcag   6840

gctctatcgc caggtcgcag aatcatccac aagtcatcca tcctcactcc catctcatgc   6900

ctcccaggca gagcaggaaa tgtcacgatc attcagcatg gcaaaactgg cgtcctcctc   6960

ctcctccctt caaacagcca ttagaaaggc agaatactcc cagggaaaat caagcctgat   7020

gtcagactcc cgaggggtgc ccagaaacag cattccaggg ggcccctcgg gggaggacca   7080

tctctacttc accccaaggc cagcgaccag gacctactcc atgccagccc agttctcaag   7140

ccattttgga cgggagggtc accccccaca cagcctgggt cgctctcggg acagccaggt   7200

ccctgtgaca agcagtgttg tccccgaggc aaaggcatcc agaggtggtc ttcccagcct   7260

ggctaatgga cagggcatat atagtgtaaa gccgctgctg gacacatcga ggaatcttcc   7320

agccacagat gaaggggata tcatttcagt ccaggagacg agctgcctag tcacagacaa   7380

aatcaaagtc accagacgac actactgcta tgagcagaac tggccccatg aatctacctc   7440

atttttctct gtgaagcagc ggatcaagtc ttttgagaac ctggccaatg ctgaccggcc   7500

tgtagccaag tccggggctt ccccattttt gtcggtgagc tccaagcctc ccattgggag   7560

gcggtcttcc ggcagcattg tttccgggag cctgggccac ccaggtgacg cagcagcaag   7620

gttgttgaga cgcagcttga gttcctgcag cgaaaaccaa agcgaagccg gcaccctcct   7680

gccccagatg gccaagtctc cctcaatcat gacactgacc atctctcggc agaacccacc   7740

agagaccagt agcaagggct ctgattcgga actaaagaaa tcacttggtc ctttgggaat   7800

tcccacccca acgatgaccc tggcttctcc tgttaagagg aacaagtcct cggtacgcca   7860

cacgcagccc tcgcccgtgt cccgctccaa gctccaggag ctgagagcct tgagcatgcc   7920

tgaccttgac aagctctgca gcgaggatta ctcagcaggg ccgagcgccg tgctcttcaa   7980

aactgagctg gagatcaccc ccaggaggtc acctggccct cctgctggag gcgtttcgtg   8040

tcccgagaag ggcgggaaca gggcctgtcc aggaggaagt ggccctaaaa ccagtgctgc   8100

tgagacaccc agttcagcca gtgatacggg tgaagctgcc caggatctgc cttttagaag   8160

aagctggtca gttaatttgg atcaacttct agtctcagcg ggggaccagc aaagattaca   8220

gtctgtttta tcgtcagtgg gatcgaaatc taccatccta actctcattc aggaagcgaa   8280

agcacaatca gagaatgaag aagatgtttg cttcatagtc ttgaatagaa aagaaggctc   8340

aggtctggga ttcagtgtgg caggagggac agatgtggag ccaaaatcaa tcacggtcca   8400

cagggtgttt tctcaggggg cggcttctca ggaagggact atgaaccgag gggatttcct   8460

tctgtcagtc aacggcgcct cactggctgg cttagcccac gggaatgtcc tgaaggttct   8520

gcaccaggca cagctgcaca aagatgccct cgtggtcatc aagaaaggga tggatcagcc   8580

caggccctct gcccggcagg agcctcccac agccaatggg aagggtttgc tgtccagaaa   8640

gaccatcccc ctggagcctg gcattgggag aagtgtggct gtacacgatg ctctgtgtgt   8700

tgaagtgctg aagacctcgg ctgggctggg actgagtctg gatgggggaa aatcatcggt   8760

gacgggagat gggcccttgg tcattaaaag agtgtacaaa ggtggtgcgg ctgaacaagc   8820

tggaataata gaagctggag atgaaattct tgctattaat gggaaacctc tggttgggct   8880

catgcacttt gatgcctgga atattatgaa gtctgtccca gaaggacctg tgcagttatt   8940

aattagaaag cataggaatt cttcatgaat tttaacaaga atcattttct cagttctctt   9000

ctttctttag caaatcagag tgacttcttt aaaccacagg ttgttgaaat ggccaacact   9060

ggtacagaca cggactataa aaatctccaa gcttgtgctt acacatgaag cctgacttaa   9120

ctgtatgtgc aacagcaatg aaattaactc cagaagcctt ccacctgcgt cacccaggcc   9180

gggagggttc cttcgttcca gtgcctgtcc cctaccttta tgttatgttt actgatgggg   9240

atacaagatg tgacacaccc ttctttattt gaaacaaaca aacatttagc tagacctttg   9300

cttccttctt gccagctctc ccaacatacc caatcctggt gatcagggaa ctaaaagtct   9360

gagggggaca caaatgtcac acctaagagg acaatcaatc attttgtatg attttgtaag   9420

taaatgacag aatgctttta ggcacattca atggaaggag gagatgtagg tctgtatatg   9480

ttaccctgaa aagagaataa gacttactta aaaaaatgaa ttatgacctg ttaggctgag   9540

ctcaggaatt gtccaaaaag gaaaaagcaa aataattaat tgagagtatt ttttagtgag   9600

tgtaatgtat aatgtacgta tgcaaagttc aactcaatag gttattgatc accatgaagt   9660

attgatcatt ttctatctca aaagtgtaag ccataaggct gttttacaga atagcacttc   9720

tgataagctg tattaaatag ccatgagctt cactgcttag agggagcaga aaggtcaaca   9780

tctaaaagca ccttacaact agtttttgaa cctgtcttga taagtgcttg aattcaagac   9840

tggtcagtcc aagagcagac aaaaatatca caagtcagtc agtcactggg tttccatttc   9900

tgaattttat gcactccaac catgaattta aactaaattt ttagaaatca agtatctttc   9960

taagtgtcct tggatttata gacaatgtat gtacaatcca aatagaggag cttaatggaa  10020

tccttttagg agactggttg gtttttttcc ctctttccca acatgtttaa gaaatgtaac  10080

attctaagta ttggatctct tttcttgacc tagtataatg acaactgcag tgacttaagt  10140

ttttgctgtt ttcgttttcc cgctttgcaa tttcctcctt ttgccaaaaa tgttttccta  10200

cagaagactg tcgtgactca cgctacttgg gaaactcact ctggccactc ctcctctggt  10260

ggcatgagct gcttcccagt agctattccg attggatatt ccgttcgtcg tcacatagct  10320

ggcttttctc tcctcatgat gtaccttatt ttcttaggta aataattcca aactctcatc  10380

gggtcataaa gaggaggaga aacagggtga gtcaaggtaa aggagcagaa atgtagttac  10440

aagccaggtc gtcttcagtg gcacaaacca acccgttgag ccctgacaac atgagtggag  10500

agtgcatttg ccatacctgt gtgcatgaca ctaagatttt atgttggaga tacttcttta  10560

aataacctac agcttgggtc tatggctgtg acccccagat tcatggaggg gctttagcca  10620

tcagctttgt acatcatcat ttttctgaat gaccaatccc actaaacatc tttgaagtcg  10680

gcctagagag gtccttcaga tgagagagaa atagctggct tgtctgagtc cagatttctc  10740

atcaactggc aatacaaagg aaaatatggt acaggagtta gttagaaagg tcttattgat  10800

tttacttcta cttttcacta cagttacagg tagaatactg taggaagtca gtgcaaggtg  10860

catgcttgat tgatagatat tgattgattg tttttcagtc tctggggtca gttttgtggt  10920

ttctgctttc ttgcctaaat caaagactat ttcaagtcaa caacactgaa aactgctttt  10980

cgcctccact cttacagctg tgcctaataa taattaatta ataaacgcac agccctatgt  11040

gaacagacag gaatttcttg tgcaatgtgg agcaaatgga atggtctcct tccgcaagtc  11100

tttttaatcc tcatatctgg agtacaaggg tagacctctg gcttaccaca tacactatgc  11160

taaagtcatc agccactgct actacatctt gccagaaggt ttccctcgcc aacaaacagt  11220

tgaaatttaa gggaagaagc aaaagctaaa ctgtctttga ccctaagata gatagaaagc  11280

tatttatttg tcttcagtgt tcaaggcatg actagtattt ctaattagcc taataaattc  11340

ccacactttc tgaagtgaac actaatggta ttgtcctact aaaactgtca ttgtttcttt  11400

ttttttaact ggtcagtcat tcacaataag ctatgagggt aaataaatat gtgttataac  11460

aagtaaaccg tagttgcaag aatataccat gaagattaaa gtaggctggg tttcatttcc  11520

atcttcccac acatctcatt gaatttgatg gttgacttaa ttggcaccat aactttgtat  11580

gatattatac attaaccttt atttatgtaa agtaaaatgc cttatatatt aaagagtaag  11640

tgcaataata tgaaatagcc tgtacatttt aaaaatgttg tcaccaagtt atataaatcc  11700

acatctctgt aaacaacctt ttttaagtaa ttttaaaaaa aataaacact ctgcttacta  11760

cttga                                                              11765


<210>  2633
<211>  2839
<212>  PRT
<213>  Homo sapiens

<400>  2633

Met Pro Ile Thr Gln Asp Asn Ala Val Leu His Leu Pro Leu Leu Tyr 
1               5                   10                  15


Gln Trp Leu Gln Asn Ser Leu Gln Glu Gly Gly Asp Gly Pro Glu Gln 
            20                  25                  30


Arg Leu Cys Gln Ala Ala Ile Gln Lys Leu Gln Glu Tyr Ile Gln Leu 
        35                  40                  45


Asn Phe Ala Val Asp Glu Ser Thr Val Pro Pro Asp His Ser Pro Pro 
    50                  55                  60


Glu Met Glu Ile Cys Thr Val Tyr Leu Thr Lys Glu Leu Gly Asp Thr 
65                  70                  75                  80


Glu Thr Val Gly Leu Ser Phe Gly Asn Ile Pro Val Phe Gly Asp Tyr 
                85                  90                  95


Gly Glu Lys Arg Arg Gly Gly Lys Lys Arg Lys Thr His Gln Gly Pro 
            100                 105                 110


Val Leu Asp Val Gly Cys Ile Trp Val Thr Glu Leu Arg Lys Asn Ser 
        115                 120                 125


Pro Ala Gly Lys Ser Gly Lys Val Arg Leu Arg Asp Glu Ile Leu Ser 
    130                 135                 140


Leu Asn Gly Gln Leu Met Val Gly Val Asp Val Ser Gly Ala Ser Tyr 
145                 150                 155                 160


Leu Ala Glu Gln Cys Trp Asn Gly Gly Phe Ile Tyr Leu Ile Met Leu 
                165                 170                 175


Arg Arg Phe Lys His Lys Ala His Ser Thr Tyr Asn Gly Asn Ser Ser 
            180                 185                 190


Asn Ser Ser Glu Pro Gly Glu Thr Pro Thr Leu Glu Leu Gly Asp Arg 
        195                 200                 205


Thr Ala Lys Lys Gly Lys Arg Thr Arg Lys Phe Gly Val Ile Ser Arg 
    210                 215                 220


Pro Pro Ala Asn Lys Ala Pro Glu Glu Ser Lys Gly Ser Ala Gly Cys 
225                 230                 235                 240


Glu Val Ser Ser Asp Pro Ser Thr Glu Leu Glu Asn Gly Pro Asp Pro 
                245                 250                 255


Glu Leu Gly Asn Gly His Val Phe Gln Leu Glu Asn Gly Pro Asp Ser 
            260                 265                 270


Leu Lys Glu Val Ala Gly Pro His Leu Glu Arg Ser Glu Val Asp Arg 
        275                 280                 285


Gly Thr Glu His Arg Ile Pro Lys Thr Asp Ala Pro Leu Thr Thr Ser 
    290                 295                 300


Asn Asp Lys Arg Arg Phe Ser Lys Gly Gly Lys Thr Asp Phe Gln Ser 
305                 310                 315                 320


Ser Asp Cys Leu Ala Arg Glu Glu Val Gly Arg Ile Trp Lys Met Glu 
                325                 330                 335


Leu Leu Lys Glu Ser Asp Gly Leu Gly Ile Gln Val Ser Gly Gly Arg 
            340                 345                 350


Gly Ser Lys Arg Ser Pro His Ala Ile Val Val Thr Gln Val Lys Glu 
        355                 360                 365


Gly Gly Ala Ala His Arg Asp Gly Arg Leu Ser Leu Gly Asp Glu Leu 
    370                 375                 380


Leu Val Ile Asn Gly His Leu Leu Val Gly Leu Ser His Glu Glu Ala 
385                 390                 395                 400


Val Ala Ile Leu Arg Ser Ala Thr Gly Met Val Gln Leu Val Val Ala 
                405                 410                 415


Ser Lys Glu Asn Ser Ala Glu Asp Leu Leu Arg Leu Thr Ser Lys Ser 
            420                 425                 430


Leu Pro Asp Leu Thr Ser Ser Val Glu Asp Val Ser Ser Trp Thr Asp 
        435                 440                 445


Asn Glu Asp Gln Glu Ala Asp Gly Glu Glu Asp Glu Gly Thr Ser Ser 
    450                 455                 460


Ser Val Gln Arg Ala Met Pro Gly Thr Asp Glu Pro Gln Asp Val Cys 
465                 470                 475                 480


Gly Ala Glu Glu Ser Lys Gly Asn Leu Glu Ser Pro Lys Gln Gly Ser 
                485                 490                 495


Asn Lys Ile Lys Leu Lys Ser Arg Leu Ser Gly Gly Val His Arg Leu 
            500                 505                 510


Glu Ser Val Glu Glu Tyr Asn Glu Leu Met Val Arg Asn Gly Asp Pro 
        515                 520                 525


Arg Ile Arg Met Leu Glu Val Ser Arg Asp Gly Arg Lys His Ser Leu 
    530                 535                 540


Pro Gln Leu Leu Asp Ser Ser Ser Ala Ser Gln Glu Tyr His Ile Val 
545                 550                 555                 560


Lys Lys Ser Thr Arg Ser Leu Ser Thr Thr Gln Val Glu Ser Pro Trp 
                565                 570                 575


Arg Leu Ile Arg Pro Ser Val Ile Ser Ile Ile Gly Leu Tyr Lys Glu 
            580                 585                 590


Lys Gly Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly Arg Asp Cys Ile 
        595                 600                 605


Arg Gly Gln Met Gly Ile Phe Val Lys Thr Ile Phe Pro Asn Gly Ser 
    610                 615                 620


Ala Ala Glu Asp Gly Arg Leu Lys Glu Gly Asp Glu Ile Leu Asp Val 
625                 630                 635                 640


Asn Gly Ile Pro Ile Lys Gly Leu Thr Phe Gln Glu Ala Ile His Thr 
                645                 650                 655


Phe Lys Gln Ile Arg Ser Gly Leu Phe Val Leu Thr Val Arg Thr Lys 
            660                 665                 670


Leu Val Ser Pro Ser Leu Thr Pro Cys Ser Thr Pro Thr His Met Ser 
        675                 680                 685


Arg Ser Ala Ser Pro Asn Phe Asn Thr Ser Gly Gly Ala Ser Ala Gly 
    690                 695                 700


Gly Ser Asp Glu Gly Ser Ser Ser Ser Leu Gly Arg Lys Thr Pro Gly 
705                 710                 715                 720


Pro Lys Asp Arg Ile Val Met Glu Val Thr Leu Asn Lys Glu Pro Arg 
                725                 730                 735


Val Gly Leu Gly Ile Gly Ala Cys Cys Leu Ala Leu Glu Asn Ser Pro 
            740                 745                 750


Pro Gly Ile Tyr Ile His Ser Leu Ala Pro Gly Ser Val Ala Lys Met 
        755                 760                 765


Glu Ser Asn Leu Ser Arg Gly Asp Gln Ile Leu Glu Val Asn Ser Val 
    770                 775                 780


Asn Val Arg His Ala Ala Leu Ser Lys Val His Ala Ile Leu Ser Lys 
785                 790                 795                 800


Cys Pro Pro Gly Pro Val Arg Leu Val Ile Gly Arg His Pro Asn Pro 
                805                 810                 815


Lys Val Ser Glu Gln Glu Met Asp Glu Val Ile Ala Arg Ser Thr Tyr 
            820                 825                 830


Gln Glu Ser Lys Glu Ala Asn Ser Ser Pro Gly Leu Gly Thr Pro Leu 
        835                 840                 845


Lys Ser Pro Ser Leu Ala Lys Lys Asp Ser Leu Ile Ser Glu Ser Glu 
    850                 855                 860


Leu Ser Gln Tyr Phe Ala His Asp Val Pro Gly Pro Leu Ser Asp Phe 
865                 870                 875                 880


Met Val Ala Gly Ser Glu Asp Glu Asp His Pro Gly Ser Gly Cys Ser 
                885                 890                 895


Thr Ser Glu Glu Gly Ser Leu Pro Pro Ser Thr Ser Thr His Lys Glu 
            900                 905                 910


Pro Gly Lys Pro Arg Ala Asn Ser Leu Val Thr Leu Gly Ser His Arg 
        915                 920                 925


Ala Ser Gly Leu Phe His Lys Gln Val Thr Val Ala Arg Gln Ala Ser 
    930                 935                 940


Leu Pro Gly Ser Pro Gln Ala Leu Arg Asn Pro Leu Leu Arg Gln Arg 
945                 950                 955                 960


Lys Val Gly Cys Tyr Asp Ala Asn Asp Ala Ser Asp Glu Glu Glu Phe 
                965                 970                 975


Asp Arg Glu Gly Asp Cys Ile Ser Leu Pro Gly Ala Leu Pro Gly Pro 
            980                 985                 990


Ile Arg Pro Leu Ser Glu Asp Asp Pro Arg Arg Val Ser Ile Ser Ser 
        995                 1000                1005


Ser Lys Gly Met Asp Val His Asn Gln Glu Glu Arg Pro Arg Lys Thr 
    1010                1015                1020


Leu Val Ser Lys Ala Ile Ser Ala Pro Leu Leu Gly Ser Ser Val Asp 
1025                1030                1035                1040


Leu Glu Glu Ser Ile Pro Glu Gly Met Val Asp Ala Ala Ser Tyr Ala 
                1045                1050                1055


Ala Asn Leu Thr Asp Ser Ala Glu Ala Pro Lys Gly Ser Pro Gly Ser 
            1060                1065                1070


Trp Trp Lys Lys Glu Leu Ser Gly Ser Ser Ser Ala Pro Lys Leu Glu 
        1075                1080                1085


Tyr Thr Val Arg Thr Asp Thr Gln Ser Pro Thr Asn Thr Gly Ser Pro 
    1090                1095                1100


Ser Ser Pro Gln Gln Lys Ser Glu Gly Leu Gly Ser Arg His Arg Pro 
1105                1110                1115                1120


Val Ala Arg Val Ser Pro His Cys Lys Arg Ser Glu Ala Glu Ala Lys 
                1125                1130                1135


Pro Ser Gly Ser Gln Thr Val Asn Leu Thr Gly Arg Ala Asn Asp Pro 
            1140                1145                1150


Cys Asp Leu Asp Ser Arg Val Gln Ala Thr Ser Val Lys Val Thr Val 
        1155                1160                1165


Ala Gly Phe Gln Pro Gly Gly Ala Val Glu Lys Glu Ser Leu Gly Lys 
    1170                1175                1180


Leu Thr Thr Gly Asp Ala Cys Val Ser Thr Ser Cys Glu Leu Ala Ser 
1185                1190                1195                1200


Ala Leu Ser His Leu Asp Ala Ser His Leu Thr Glu Asn Leu Pro Lys 
                1205                1210                1215


Ala Ala Ser Glu Leu Gly Gln Gln Pro Met Thr Glu Leu Asp Ser Ser 
            1220                1225                1230


Ser Asp Leu Ile Ser Ser Pro Gly Lys Lys Gly Ala Ala His Pro Asp 
        1235                1240                1245


Pro Ser Lys Thr Ser Val Asp Thr Gly Gln Val Ser Arg Pro Glu Asn 
    1250                1255                1260


Pro Ser Gln Pro Ala Ser Pro Arg Val Thr Lys Cys Lys Ala Arg Ser 
1265                1270                1275                1280


Pro Val Arg Leu Pro His Glu Gly Ser Pro Ser Pro Gly Glu Lys Ala 
                1285                1290                1295


Ala Ala Pro Pro Asp Tyr Ser Lys Thr Arg Ser Ala Ser Glu Thr Ser 
            1300                1305                1310


Thr Pro His Asn Thr Arg Arg Val Ala Ala Leu Arg Gly Ala Gly Pro 
        1315                1320                1325


Gly Ala Glu Gly Met Thr Pro Ala Gly Ala Val Leu Pro Gly Asp Pro 
    1330                1335                1340


Leu Thr Ser Gln Glu Gln Arg Gln Gly Ala Pro Gly Asn His Ser Lys 
1345                1350                1355                1360


Ala Leu Glu Met Thr Gly Ile His Ala Pro Glu Ser Ser Gln Glu Pro 
                1365                1370                1375


Ser Leu Leu Glu Gly Ala Asp Ser Val Ser Ser Arg Ala Pro Gln Ala 
            1380                1385                1390


Ser Leu Ser Met Leu Pro Ser Thr Asp Asn Thr Lys Glu Ala Cys Gly 
        1395                1400                1405


His Val Ser Gly His Cys Cys Pro Gly Gly Ser Arg Glu Ser Pro Val 
    1410                1415                1420


Thr Asp Ile Asp Ser Phe Ile Lys Glu Leu Asp Ala Ser Ala Ala Arg 
1425                1430                1435                1440


Ser Pro Ser Ser Gln Thr Gly Asp Ser Gly Ser Gln Glu Gly Ser Ala 
                1445                1450                1455


Gln Gly His Pro Pro Ala Gly Ala Gly Gly Gly Ser Ser Cys Arg Ala 
            1460                1465                1470


Glu Pro Val Pro Gly Gly Gln Thr Ser Ser Pro Arg Arg Ala Trp Ala 
        1475                1480                1485


Ala Gly Ala Pro Ala Tyr Pro Gln Trp Ala Ser Gln Pro Ser Val Leu 
    1490                1495                1500


Asp Ser Ile Asn Pro Asp Lys His Phe Thr Val Asn Lys Asn Phe Leu 
1505                1510                1515                1520


Ser Asn Tyr Ser Arg Asn Phe Ser Ser Phe His Glu Asp Ser Thr Ser 
                1525                1530                1535


Leu Ser Gly Leu Gly Asp Ser Thr Glu Pro Ser Leu Ser Ser Met Tyr 
            1540                1545                1550


Gly Asp Ala Glu Asp Ser Ser Ser Asp Pro Glu Ser Leu Thr Glu Ala 
        1555                1560                1565


Pro Arg Ala Ser Ala Arg Asp Gly Trp Ser Pro Pro Arg Ser Arg Val 
    1570                1575                1580


Ser Leu His Lys Glu Asp Pro Ser Glu Ser Glu Glu Glu Gln Ile Glu 
1585                1590                1595                1600


Ile Cys Ser Thr Arg Gly Cys Pro Asn Pro Pro Ser Ser Pro Ala His 
                1605                1610                1615


Leu Pro Thr Gln Ala Ala Ile Cys Pro Ala Ser Ala Lys Val Leu Ser 
            1620                1625                1630


Leu Lys Tyr Ser Thr Pro Arg Glu Ser Val Ala Ser Pro Arg Glu Lys 
        1635                1640                1645


Ala Ala Cys Leu Pro Gly Ser Tyr Thr Ser Gly Pro Asp Ser Ser Gln 
    1650                1655                1660


Pro Ser Ser Leu Leu Glu Met Ser Ser Gln Glu His Glu Thr His Ala 
1665                1670                1675                1680


Asp Ile Ser Thr Ser Gln Asn His Arg Pro Ser Cys Ala Glu Glu Thr 
                1685                1690                1695


Thr Glu Val Thr Ser Ala Ser Ser Ala Met Glu Asn Ser Pro Leu Ser 
            1700                1705                1710


Lys Val Ala Arg His Phe His Ser Pro Pro Ile Ile Leu Ser Ser Pro 
        1715                1720                1725


Asn Met Val Asn Gly Leu Glu His Asp Leu Leu Asp Asp Glu Thr Leu 
    1730                1735                1740


Asn Gln Tyr Glu Thr Ser Ile Asn Ala Ala Ala Ser Leu Ser Ser Phe 
1745                1750                1755                1760


Ser Val Asp Val Pro Lys Asn Gly Glu Ser Val Leu Glu Asn Leu His 
                1765                1770                1775


Ile Ser Glu Ser Gln Asp Leu Asp Asp Leu Leu Gln Lys Pro Lys Met 
            1780                1785                1790


Ile Ala Arg Arg Pro Ile Met Ala Trp Phe Lys Glu Ile Asn Lys His 
        1795                1800                1805


Asn Gln Gly Thr His Leu Arg Ser Lys Thr Glu Lys Glu Gln Pro Leu 
    1810                1815                1820


Met Pro Ala Arg Ser Pro Asp Ser Lys Ile Gln Met Val Ser Ser Ser 
1825                1830                1835                1840


Gln Lys Lys Gly Val Thr Val Pro His Ser Pro Pro Gln Pro Lys Thr 
                1845                1850                1855


Asn Leu Glu Asn Lys Asp Leu Ser Lys Lys Ser Pro Ala Glu Met Leu 
            1860                1865                1870


Leu Thr Asn Gly Gln Lys Ala Lys Cys Gly Pro Lys Leu Lys Arg Leu 
        1875                1880                1885


Ser Leu Lys Gly Lys Ala Lys Val Asn Ser Glu Ala Pro Ala Ala Asn 
    1890                1895                1900


Ala Val Lys Ala Gly Gly Thr Asp His Arg Lys Pro Leu Ile Ser Pro 
1905                1910                1915                1920


Gln Thr Ser His Lys Thr Leu Ser Lys Ala Val Ser Gln Arg Leu His 
                1925                1930                1935


Val Ala Asp His Glu Asp Pro Asp Arg Asn Thr Thr Ala Ala Pro Arg 
            1940                1945                1950


Ser Pro Gln Cys Val Leu Glu Ser Lys Pro Pro Leu Ala Thr Ser Gly 
        1955                1960                1965


Pro Leu Lys Pro Ser Val Ser Asp Thr Ser Ile Arg Thr Phe Val Ser 
    1970                1975                1980


Pro Leu Thr Ser Pro Lys Pro Val Pro Glu Gln Gly Met Trp Ser Arg 
1985                1990                1995                2000


Phe His Met Ala Val Leu Ser Glu Pro Asp Arg Gly Cys Pro Thr Thr 
                2005                2010                2015


Pro Lys Ser Pro Lys Cys Arg Ala Glu Gly Arg Ala Pro Arg Ala Asp 
            2020                2025                2030


Ser Gly Pro Val Ser Pro Ala Ala Ser Arg Asn Gly Met Ser Val Ala 
        2035                2040                2045


Gly Asn Arg Gln Ser Glu Pro Arg Leu Ala Ser His Val Ala Ala Asp 
    2050                2055                2060


Thr Ala Gln Pro Arg Pro Thr Gly Glu Lys Gly Gly Asn Ile Met Ala 
2065                2070                2075                2080


Ser Asp Arg Leu Glu Arg Thr Asn Gln Leu Lys Ile Val Glu Ile Ser 
                2085                2090                2095


Ala Glu Ala Val Ser Glu Thr Val Cys Gly Asn Lys Pro Ala Glu Ser 
            2100                2105                2110


Asp Arg Arg Gly Gly Cys Leu Ala Gln Gly Asn Cys Gln Glu Lys Ser 
        2115                2120                2125


Glu Ile Arg Leu Tyr Arg Gln Val Ala Glu Ser Ser Thr Ser His Pro 
    2130                2135                2140


Ser Ser Leu Pro Ser His Ala Ser Gln Ala Glu Gln Glu Met Ser Arg 
2145                2150                2155                2160


Ser Phe Ser Met Ala Lys Leu Ala Ser Ser Ser Ser Ser Leu Gln Thr 
                2165                2170                2175


Ala Ile Arg Lys Ala Glu Tyr Ser Gln Gly Lys Ser Ser Leu Met Ser 
            2180                2185                2190


Asp Ser Arg Gly Val Pro Arg Asn Ser Ile Pro Gly Gly Pro Ser Gly 
        2195                2200                2205


Glu Asp His Leu Tyr Phe Thr Pro Arg Pro Ala Thr Arg Thr Tyr Ser 
    2210                2215                2220


Met Pro Ala Gln Phe Ser Ser His Phe Gly Arg Glu Gly His Pro Pro 
2225                2230                2235                2240


His Ser Leu Gly Arg Ser Arg Asp Ser Gln Val Pro Val Thr Ser Ser 
                2245                2250                2255


Val Val Pro Glu Ala Lys Ala Ser Arg Gly Gly Leu Pro Ser Leu Ala 
            2260                2265                2270


Asn Gly Gln Gly Ile Tyr Ser Val Lys Pro Leu Leu Asp Thr Ser Arg 
        2275                2280                2285


Asn Leu Pro Ala Thr Asp Glu Gly Asp Ile Ile Ser Val Gln Glu Thr 
    2290                2295                2300


Ser Cys Leu Val Thr Asp Lys Ile Lys Val Thr Arg Arg His Tyr Cys 
2305                2310                2315                2320


Tyr Glu Gln Asn Trp Pro His Glu Ser Thr Ser Phe Phe Ser Val Lys 
                2325                2330                2335


Gln Arg Ile Lys Ser Phe Glu Asn Leu Ala Asn Ala Asp Arg Pro Val 
            2340                2345                2350


Ala Lys Ser Gly Ala Ser Pro Phe Leu Ser Val Ser Ser Lys Pro Pro 
        2355                2360                2365


Ile Gly Arg Arg Ser Ser Gly Ser Ile Val Ser Gly Ser Leu Gly His 
    2370                2375                2380


Pro Gly Asp Ala Ala Ala Arg Leu Leu Arg Arg Ser Leu Ser Ser Cys 
2385                2390                2395                2400


Ser Glu Asn Gln Ser Glu Ala Gly Thr Leu Leu Pro Gln Met Ala Lys 
                2405                2410                2415


Ser Pro Ser Ile Met Thr Leu Thr Ile Ser Arg Gln Asn Pro Pro Glu 
            2420                2425                2430


Thr Ser Ser Lys Gly Ser Asp Ser Glu Leu Lys Lys Ser Leu Gly Pro 
        2435                2440                2445


Leu Gly Ile Pro Thr Pro Thr Met Thr Leu Ala Ser Pro Val Lys Arg 
    2450                2455                2460


Asn Lys Ser Ser Val Arg His Thr Gln Pro Ser Pro Val Ser Arg Ser 
2465                2470                2475                2480


Lys Leu Gln Glu Leu Arg Ala Leu Ser Met Pro Asp Leu Asp Lys Leu 
                2485                2490                2495


Cys Ser Glu Asp Tyr Ser Ala Gly Pro Ser Ala Val Leu Phe Lys Thr 
            2500                2505                2510


Glu Leu Glu Ile Thr Pro Arg Arg Ser Pro Gly Pro Pro Ala Gly Gly 
        2515                2520                2525


Val Ser Cys Pro Glu Lys Gly Gly Asn Arg Ala Cys Pro Gly Gly Ser 
    2530                2535                2540


Gly Pro Lys Thr Ser Ala Ala Glu Thr Pro Ser Ser Ala Ser Asp Thr 
2545                2550                2555                2560


Gly Glu Ala Ala Gln Asp Leu Pro Phe Arg Arg Ser Trp Ser Val Asn 
                2565                2570                2575


Leu Asp Gln Leu Leu Val Ser Ala Gly Asp Gln Gln Arg Leu Gln Ser 
            2580                2585                2590


Val Leu Ser Ser Val Gly Ser Lys Ser Thr Ile Leu Thr Leu Ile Gln 
        2595                2600                2605


Glu Ala Lys Ala Gln Ser Glu Asn Glu Glu Asp Val Cys Phe Ile Val 
    2610                2615                2620


Leu Asn Arg Lys Glu Gly Ser Gly Leu Gly Phe Ser Val Ala Gly Gly 
2625                2630                2635                2640


Thr Asp Val Glu Pro Lys Ser Ile Thr Val His Arg Val Phe Ser Gln 
                2645                2650                2655


Gly Ala Ala Ser Gln Glu Gly Thr Met Asn Arg Gly Asp Phe Leu Leu 
            2660                2665                2670


Ser Val Asn Gly Ala Ser Leu Ala Gly Leu Ala His Gly Asn Val Leu 
        2675                2680                2685


Lys Val Leu His Gln Ala Gln Leu His Lys Asp Ala Leu Val Val Ile 
    2690                2695                2700


Lys Lys Gly Met Asp Gln Pro Arg Pro Ser Ala Arg Gln Glu Pro Pro 
2705                2710                2715                2720


Thr Ala Asn Gly Lys Gly Leu Leu Ser Arg Lys Thr Ile Pro Leu Glu 
                2725                2730                2735


Pro Gly Ile Gly Arg Ser Val Ala Val His Asp Ala Leu Cys Val Glu 
            2740                2745                2750


Val Leu Lys Thr Ser Ala Gly Leu Gly Leu Ser Leu Asp Gly Gly Lys 
        2755                2760                2765


Ser Ser Val Thr Gly Asp Gly Pro Leu Val Ile Lys Arg Val Tyr Lys 
    2770                2775                2780


Gly Gly Ala Ala Glu Gln Ala Gly Ile Ile Glu Ala Gly Asp Glu Ile 
2785                2790                2795                2800


Leu Ala Ile Asn Gly Lys Pro Leu Val Gly Leu Met His Phe Asp Ala 
                2805                2810                2815


Trp Asn Ile Met Lys Ser Val Pro Glu Gly Pro Val Gln Leu Leu Ile 
            2820                2825                2830


Arg Lys His Arg Asn Ser Ser 
        2835


<210>  2634
<211>  11812
<212>  DNA
<213>  Homo sapiens

<400>  2634
agaagtgtgg cgtcttggtc caggatgcag gtccctgatt cgggttggac gtggtcatca     60

aacccagaaa ttgaaggatc ttgggcctgc cttgatgttc atttctctca tctataaaat    120

tgaaggctgg aggaggtgtg aatgagccca gggaaggaca cacggccact gctggaggga    180

tcctccattc ctgtgtcatt tgcatgggtc ctgctgtgaa atgaacctgg cagggacttg    240

ttagacactt ccttccttcc ctcattgagc actccagtgc cattgttcca cagttgttct    300

aattgggtcc tagcttcctc ctgccaaggc aaacagcata gtctcgagta ggtgtcccta    360

ggctcatctg ccagcctgaa catgaacaca ggcaaagctg atgatggcca gggaccccag    420

gggacgtggg gccctgtggg gtctggcccc caggagcaag acctctgatg atgctggtgt    480

ctgggagtga gcaccatgcc catcacccag gacaatgccg tgctgcacct gcccctcctc    540

taccagtggc tgcagaacag cctgcaggaa ggtggggatg ggccggagca gcggctctgc    600

caggcggcca tccagaagct gcaggagtac atccagctga actttgctgt ggatgagagt    660

acggtcccac ctgatcacag cccccccgaa atggagatct gtactgtgta cctcaccaag    720

gagctggggg acacagagac tgtgggcctg agttttggga acatccctgt tttcggggac    780

tatggtgaaa agcgcagggg gggcaagaag aggaaaaccc accagggtcc tgtgctggat    840

gtgggctgca tctgggtgac agagctgagg aagaacagcc cagcagggaa gagtgggaag    900

gtccgactgc gggatgagat cctctcactg aatgggcagc tgatggttgg agttgatgtc    960

agtggggcca gttacctggc tgagcagtgc tggaatggcg gctttatcta cctgatcatg   1020

ctgcgtcgct ttaagcacaa agcccactcc acttataatg gcaacagtag caacagctct   1080

gaaccaggag aaacacctac cttggagctg ggtgaccgaa ctgcgaaaaa ggggaaacga   1140

accagaaagt ttggggtcat ctccaggcct cctgccaaca aggcccctga agaatccaag   1200

ggcagcgctg gctgtgaggt gtccagtgac cccagcactg agctggagaa cggccctgac   1260

cctgaacttg gaaacggcca tgtctttcag ctagaaaatg gcccagattc tctcaaggag   1320

gtggctggac cccatctaga gaggtcagaa gtggacagag ggacagagca tagaattcca   1380

aagacagatg ctcctctgac cacaagcaat gacaaacgcc gcttctcaaa aggtgggaag   1440

acggacttcc aatcgagtga ctgcctggca cgggaggaag ttggccgaat atggaagatg   1500

gagctgctca aagaatcgga tgggctggga attcaggtta gtggaggccg aggatcaaag   1560

cgctcacctc acgctatcgt tgtcactcaa gtgaaggaag gaggtgccgc tcacagggat   1620

ggcaggctgt ccttaggaga tgagctgctg gtaatcaatg gtcatttact ggtcgggctc   1680

tcccacgagg aagcagtggc cattcttcgc tccgccacgg gaatggtgca gcttgtggtg   1740

gccagcaagg aaaactccgc agaggacctc ctcaggttaa catctaagag cttgccagat   1800

ctgaccagct cggtagaaga tgtgtcctcc tggactgata acgaagacca ggaggcagac   1860

ggggaagagg acgaaggaac cagctcttct gtccagagag caatgcctgg gacagatgaa   1920

ccccaagatg tgtgcggtgc tgaggaatcc aaggggaact tggaaagtcc caaacagggc   1980

agcaataaaa tcaagctcaa gagtcgcctt tcagggggtg tacaccgcct tgagtcagtt   2040

gaagaatata acgagctgat ggtgcggaat ggggaccccc ggatccggat gttggaggtc   2100

tcccgagatg gccggaaaca ctccctcccg cagctgctgg actcttccag tgcctcacag   2160

gaataccaca ttgtgaagaa gtctacccgc tccttaagca cgactcaggt ggaatctcct   2220

tggaggctca ttcggccatc cgtcatctcg atcattgggt tgtacaaaga aaaaggcaag   2280

ggccttggct ttagtattgc tggaggtcga gactgcattc gtggacagat ggggattttt   2340

gtcaagacca tcttcccaaa tggatcagct gcagaggacg gaagacttaa agaaggggat   2400

gaaatcctag atgtaaatgg aataccaata aagggcttga catttcaaga agccattcat   2460

acctttaagc aaatccggag tggattattt gttttaacgg tacgcacaaa gttggtgagc   2520

cccagcctca caccctgctc gacacccaca cacatgagca gatccgcctc cccgaacttc   2580

aataccagtg ggggagcctc agcgggaggt tccgatgaag gcagttcttc atccctgggt   2640

cggaagaccc ctgggcccaa ggacaggatc gtcatggaag taacactcaa caaagagcca   2700

agagttggat taggcattgg tgcctgctgc ttggctctgg aaaacagtcc tcctggcatc   2760

tacattcaca gccttgctcc aggatcagtg gccaagatgg agagcaacct gagccgcggg   2820

gatcaaatcc tggaagtgaa ctccgtcaac gtccgccatg ctgctttaag caaagtccac   2880

gccatcttga gtaaatgccc tccaggaccc gttcgccttg tcatcggccg gcaccctaat   2940

ccaaaggttt ccgagcagga aatggatgaa gtcatagcac gcagcactta tcaggagagc   3000

aaagaggcca attcctctcc tggcttaggt acccccttga agagtccctc tcttgcaaaa   3060

aaggactccc ttatttctga atctgaactc tcccagtact ttgcccacga tgtccctggc   3120

cccttgtcag acttcatggt ggccggttct gaggacgagg atcacccggg aagtggctgc   3180

agcacgtcgg aggagggcag cctgcctccc agcacctcca ctcacaagga gcctggaaaa   3240

cccagagcca acagcctcgt gactcttggg agccatcggg cttctgggct cttccacaag   3300

caggtgacag ttgccagaca agccagtctc cccggaagcc cacaggccct ccgaaaccct   3360

ctcctccgcc agaggaaggt aggctgctac gatgccaacg atgccagtga tgaggaagag   3420

tttgacagag aaggggactg catttcactc ccaggggccc tcccgggtcc catcaggcct   3480

ctgtcagagg atgacccgag gcgtgtctca atttcctctt ccaagggcat ggacgtccac   3540

aaccaagagg aacgaccccg gaaaacactg gtgagcaagg ccatctcggc acctcttctt   3600

ggtagctcag tggacttaga ggagagtatc ccagagggca tggtggatgc tgcgtcctat   3660

gcagccaacc tcacggactc tgcagaggcc cccaagggga gccctggaag ctggtggaag   3720

aaggaactgt caggatcaag tagcgcaccc aaattggaat acacagtccg tacagacacc   3780

cagagtccga cgaacactgg gagccccagt tccccccagc agaaaagtga aggcctgggc   3840

tccaggcaca gaccagtggc cagggtaagc ccccactgca agagatccga ggctgaggcc   3900

aagcccagtg gctcacagac agtgaacctg actggcagag ccaatgatcc atgcgatctg   3960

gactcgagag tccaggccac ttctgtcaaa gtgactgtcg ctggctttca gccaggtgga   4020

gctgtggaga aggaatctct gggaaagctg accactggag atgcttgtgt ctctaccagc   4080

tgtgaactag ccagtgctct gtcccatctg gatgccagcc acctcacaga gaacctgccc   4140

aaagctgcat cagagctggg gcaacaaccc atgactgaac tggacagctc ctcagacctc   4200

atctcttccc cagggaagaa gggggccgct catcctgacc ccagcaagac ctctgtagac   4260

acagggcaag tcagtcggcc agagaatccc agccagcctg catcgcccag ggtcaccaag   4320

tgcaaggcca ggtctccagt caggctcccc catgagggca gcccctcccc gggggagaaa   4380

gcagcggctc cccctgacta cagcaagact cgatcagcat cggaaaccag cacaccccac   4440

aataccagga gggtggctgc cctcagggga gcgggacctg gagcagaggg aatgacacca   4500

gctggtgctg tcctgccagg agaccccctc acatcccagg agcagagaca gggagctcca   4560

ggtaaccaca gtaaggctct ggaaatgaca ggaatccatg cacctgaaag ctcccaggag   4620

ccttccctgc tggagggagc agattctgtg tcctcaaggg caccgcaggc cagcctctcc   4680

atgctgccat ccactgacaa caccaaagaa gcatgtggcc atgtctcggg gcactgctgc   4740

ccagggggga gtagagagag ccctgtgacg gacattgaca gcttcatcaa ggagctggat   4800

gcttctgcag caaggtctcc gtcttcccag acgggggaca gtggctctca ggagggcagt   4860

gctcagggcc acccaccagc cggggctgga ggtgggagct cctgccgtgc cgaaccagtc   4920

ccggggggcc agacctcctc cccgaggagg gcctgggctg ctggtgcccc cgcctaccca   4980

caatgggcct cccagccttc ggttttagat tcaattaatc ccgacaaaca ttttactgtg   5040

aacaaaaact ttctgagcaa ctactctaga aattttagca gttttcatga agacagcacc   5100

tccctatcag gcctgggtga cagcacggag ccgtctctgt catccatgta tggcgatgct   5160

gaggattctt cttctgaccc tgagtcactc actgaagccc cacgagcttc tgccagggac   5220

ggctggtccc ctcctcgttc ccgtgtgtct ttgcacaagg aagatccttc ggagtcagaa   5280

gaggaacaga ttgagatttg ttccacacgt ggctgcccca atccaccctc gagtcctgct   5340

catcttccca cccaggctgc catctgtcct gcctcagcca aagttctgtc attaaaatac   5400

agcactccga gagagtcggt ggccagtccc cgtgagaagg ccgcctgctt gccaggctca   5460

tacacttcag gcccagactc ttcccagcca tcatcactct tggagatgag ctctcaggag   5520

catgaaactc atgcggacat aagcacttca cagaaccaca ggccctcgtg tgcagaagaa   5580

accacagaag tcaccagcgc tagctcagcc atggaaaaca gtccgctgtc taaagtagcc   5640

aggcattttc acagtccgcc catcattctc agctccccca acatggtaaa tggcttggaa   5700

catgacctgc tagatgacga aaccctgaat caatacgaaa caagcattaa tgcagctgcc   5760

agtctgtcct ccttcagtgt ggatgtccct aagaatggag aatctgtttt ggaaaacctc   5820

cacatctctg aaagtcaaga cctggatgac ttgctacaga aaccaaaaat gatcgctagg   5880

aggcccatca tggcctggtt taaagaaata aataaacata accaaggcac acatttgagg   5940

agcaaaaccg agaaggaaca acctctaatg cctgccagaa gtcccgactc caagattcag   6000

atggtgagtt caagccaaaa aaagggcgtt actgtgcctc atagccctcc tcagccgaaa   6060

acaaacctgg aaaataagga cctgtctaag aagagtccgg cagaaatgct tctgactaat   6120

ggtcagaagg caaagtgtgg tccgaagctg aagaggctca gcctcaaggg caaggccaaa   6180

gtcaactctg aggcccctgc tgcgaatgct gtgaaggctg gggggacgga ccacaggaaa   6240

cccttgatct caccccagac ctcccacaaa acactttcta aggcagtgtc acagcggctc   6300

catgtagccg accacgagga ccctgacaga aacaccacag ctgcccccag gtccccccag   6360

tgtgtgctgg aaagcaagcc acctcttgcc acctctgggc cactgaaacc ctcagtgtct   6420

gacacgagca tcaggacatt tgtctcgccc ctgacctctc ccaagcctgt tcctgagcaa   6480

ggcatgtgga gcaggttcca catggctgtc ctctctgaac ccgacagagg ttgcccaacc   6540

acccctaaat ctcctaagtg tagagcagag ggcagggcgc cccgtgctga ctccgggccg   6600

gtgagtccgg cagcgtctag gaacggcatg tccgtggcag ggaacagaca gagtgagccg   6660

cgcctggcca gccatgtggc agcagacaca gcccaaccca ggccgactgg cgaaaaagga   6720

ggcaacataa tggccagcga tcgcctcgaa agaacaaacc agctgaaaat cgtggagatt   6780

tctgctgaag cagtgtcaga gactgtatgt ggtaacaagc cagctgaaag cgacagacgg   6840

ggagggtgct tggcccaggg caactgtcag gagaagagtg aaatcaggct ctatcgccag   6900

gtcgcagaat catccacaag tcatccatcc tcactcccat ctcatgcctc ccaggcagag   6960

caggaaatgt cacgatcatt cagcatggca aaactggcgt cctcctcctc ctcccttcaa   7020

acagccatta gaaaggcaga atactcccag ggaaaatcaa gcctgatgtc agactcccga   7080

ggggtgccca gaaacagcat tccagggggc ccctcggggg aggaccatct ctacttcacc   7140

ccaaggccag cgaccaggac ctactccatg ccagcccagt tctcaagcca ttttggacgg   7200

gagggtcacc ccccacacag cctgggtcgc tctcgggaca gccaggtccc tgtgacaagc   7260

agtgttgtcc ccgaggcaaa ggcatccaga ggtggtcttc ccagcctggc taatggacag   7320

ggcatatata gtgtaaagcc gctgctggac acatcgagga atcttccagc cacagatgaa   7380

ggggatatca tttcagtcca ggagacgagc tgcctagtca cagacaaaat caaagtcacc   7440

agacgacact actgctatga gcagaactgg ccccatgaat ctacctcatt tttctctgtg   7500

aagcagcgga tcaagtcttt tgagaacctg gccaatgctg accggcctgt agccaagtcc   7560

ggggcttccc catttttgtc ggtgagctcc aagcctccca ttgggaggcg gtcttccggc   7620

agcattgttt ccgggagcct gggccaccca ggtgacgcag cagcaaggtt gttgagacgc   7680

agcttgagtt cctgcagcga aaaccaaagc gaagccggca ccctcctgcc ccagatggcc   7740

aagtctccct caatcatgac actgaccatc tctcggcaga acccaccaga gaccagtagc   7800

aagggctctg attcggaact aaagaaatca cttggtcctt tgggaattcc caccccaacg   7860

atgaccctgg cttctcctgt taagaggaac aagtcctcgg tacgccacac gcagccctcg   7920

cccgtgtccc gctccaagct ccaggagctg agagccttga gcatgcctga ccttgacaag   7980

ctctgcagcg aggattactc agcagggccg agcgccgtgc tcttcaaaac tgagctggag   8040

atcaccccca ggaggtcacc tggccctcct gctggaggcg tttcgtgtcc cgagaagggc   8100

gggaacaggg cctgtccagg aggaagtggc cctaaaacca gtgctgctga gacacccagt   8160

tcagccagtg atacgggtga agctgcccag gatctgcctt ttagaagaag ctggtcagtt   8220

aatttggatc aacttctagt ctcagcgggg gaccagcaaa gattacagtc tgttttatcg   8280

tcagtgggat cgaaatctac catcctaact ctcattcagg aagcgaaagc acaatcagag   8340

aatgaagaag atgtttgctt catagtcttg aatagaaaag aaggctcagg tctgggattc   8400

agtgtggcag gagggacaga tgtggagcca aaatcaatca cggtccacag ggtgttttct   8460

cagggggcgg cttctcagga agggactatg aaccgagggg atttccttct gtcagtcaac   8520

ggcgcctcac tggctggctt agcccacggg aatgtcctga aggttctgca ccaggcacag   8580

ctgcacaaag atgccctcgt ggtcatcaag aaagggatgg atcagcccag gccctctgcc   8640

cggcaggagc ctcccacagc caatgggaag ggtttgctgt ccagaaagac catccccctg   8700

gagcctggca ttgggagaag tgtggctgta cacgatgctc tgtgtgttga agtgctgaag   8760

acctcggctg ggctgggact gagtctggat gggggaaaat catcggtgac gggagatggg   8820

cccttggtca ttaaaagagt gtacaaaggt ggtgcggctg aacaagctgg aataatagaa   8880

gctggagatg aaattcttgc tattaatggg aaacctctgg ttgggctcat gcactttgat   8940

gcctggaata ttatgaagtc tgtcccagaa ggacctgtgc agttattaat tagaaagcat   9000

aggaattctt catgaatttt aacaagaatc attttctcag ttctcttctt tctttagcaa   9060

atcagagtga cttctttaaa ccacaggttg ttgaaatggc caacactggt acagacacgg   9120

actataaaaa tctccaagct tgtgcttaca catgaagcct gacttaactg tatgtgcaac   9180

agcaatgaaa ttaactccag aagccttcca cctgcgtcac ccaggccggg agggttcctt   9240

cgttccagtg cctgtcccct acctttatgt tatgtttact gatggggata caagatgtga   9300

cacacccttc tttatttgaa acaaacaaac atttagctag acctttgctt ccttcttgcc   9360

agctctccca acatacccaa tcctggtgat cagggaacta aaagtctgag ggggacacaa   9420

atgtcacacc taagaggaca atcaatcatt ttgtatgatt ttgtaagtaa atgacagaat   9480

gcttttaggc acattcaatg gaaggaggag atgtaggtct gtatatgtta ccctgaaaag   9540

agaataagac ttacttaaaa aaatgaatta tgacctgtta ggctgagctc aggaattgtc   9600

caaaaaggaa aaagcaaaat aattaattga gagtattttt tagtgagtgt aatgtataat   9660

gtacgtatgc aaagttcaac tcaataggtt attgatcacc atgaagtatt gatcattttc   9720

tatctcaaaa gtgtaagcca taaggctgtt ttacagaata gcacttctga taagctgtat   9780

taaatagcca tgagcttcac tgcttagagg gagcagaaag gtcaacatct aaaagcacct   9840

tacaactagt ttttgaacct gtcttgataa gtgcttgaat tcaagactgg tcagtccaag   9900

agcagacaaa aatatcacaa gtcagtcagt cactgggttt ccatttctga attttatgca   9960

ctccaaccat gaatttaaac taaattttta gaaatcaagt atctttctaa gtgtccttgg  10020

atttatagac aatgtatgta caatccaaat agaggagctt aatggaatcc ttttaggaga  10080

ctggttggtt tttttccctc tttcccaaca tgtttaagaa atgtaacatt ctaagtattg  10140

gatctctttt cttgacctag tataatgaca actgcagtga cttaagtttt tgctgttttc  10200

gttttcccgc tttgcaattt cctccttttg ccaaaaatgt tttcctacag aagactgtcg  10260

tgactcacgc tacttgggaa actcactctg gccactcctc ctctggtggc atgagctgct  10320

tcccagtagc tattccgatt ggatattccg ttcgtcgtca catagctggc ttttctctcc  10380

tcatgatgta ccttattttc ttaggtaaat aattccaaac tctcatcggg tcataaagag  10440

gaggagaaac agggtgagtc aaggtaaagg agcagaaatg tagttacaag ccaggtcgtc  10500

ttcagtggca caaaccaacc cgttgagccc tgacaacatg agtggagagt gcatttgcca  10560

tacctgtgtg catgacacta agattttatg ttggagatac ttctttaaat aacctacagc  10620

ttgggtctat ggctgtgacc cccagattca tggaggggct ttagccatca gctttgtaca  10680

tcatcatttt tctgaatgac caatcccact aaacatcttt gaagtcggcc tagagaggtc  10740

cttcagatga gagagaaata gctggcttgt ctgagtccag atttctcatc aactggcaat  10800

acaaaggaaa atatggtaca ggagttagtt agaaaggtct tattgatttt acttctactt  10860

ttcactacag ttacaggtag aatactgtag gaagtcagtg caaggtgcat gcttgattga  10920

tagatattga ttgattgttt ttcagtctct ggggtcagtt ttgtggtttc tgctttcttg  10980

cctaaatcaa agactatttc aagtcaacaa cactgaaaac tgcttttcgc ctccactctt  11040

acagctgtgc ctaataataa ttaattaata aacgcacagc cctatgtgaa cagacaggaa  11100

tttcttgtgc aatgtggagc aaatggaatg gtctccttcc gcaagtcttt ttaatcctca  11160

tatctggagt acaagggtag acctctggct taccacatac actatgctaa agtcatcagc  11220

cactgctact acatcttgcc agaaggtttc cctcgccaac aaacagttga aatttaaggg  11280

aagaagcaaa agctaaactg tctttgaccc taagatagat agaaagctat ttatttgtct  11340

tcagtgttca aggcatgact agtatttcta attagcctaa taaattccca cactttctga  11400

agtgaacact aatggtattg tcctactaaa actgtcattg tttctttttt tttaactggt  11460

cagtcattca caataagcta tgagggtaaa taaatatgtg ttataacaag taaaccgtag  11520

ttgcaagaat ataccatgaa gattaaagta ggctgggttt catttccatc ttcccacaca  11580

tctcattgaa tttgatggtt gacttaattg gcaccataac tttgtatgat attatacatt  11640

aacctttatt tatgtaaagt aaaatgcctt atatattaaa gagtaagtgc aataatatga  11700

aatagcctgt acattttaaa aatgttgtca ccaagttata taaatccaca tctctgtaaa  11760

caaccttttt taagtaattt taaaaaaaat aaacactctg cttactactt ga          11812


<210>  2635
<211>  2839
<212>  PRT
<213>  Homo sapiens

<400>  2635

Met Pro Ile Thr Gln Asp Asn Ala Val Leu His Leu Pro Leu Leu Tyr 
1               5                   10                  15


Gln Trp Leu Gln Asn Ser Leu Gln Glu Gly Gly Asp Gly Pro Glu Gln 
            20                  25                  30


Arg Leu Cys Gln Ala Ala Ile Gln Lys Leu Gln Glu Tyr Ile Gln Leu 
        35                  40                  45


Asn Phe Ala Val Asp Glu Ser Thr Val Pro Pro Asp His Ser Pro Pro 
    50                  55                  60


Glu Met Glu Ile Cys Thr Val Tyr Leu Thr Lys Glu Leu Gly Asp Thr 
65                  70                  75                  80


Glu Thr Val Gly Leu Ser Phe Gly Asn Ile Pro Val Phe Gly Asp Tyr 
                85                  90                  95


Gly Glu Lys Arg Arg Gly Gly Lys Lys Arg Lys Thr His Gln Gly Pro 
            100                 105                 110


Val Leu Asp Val Gly Cys Ile Trp Val Thr Glu Leu Arg Lys Asn Ser 
        115                 120                 125


Pro Ala Gly Lys Ser Gly Lys Val Arg Leu Arg Asp Glu Ile Leu Ser 
    130                 135                 140


Leu Asn Gly Gln Leu Met Val Gly Val Asp Val Ser Gly Ala Ser Tyr 
145                 150                 155                 160


Leu Ala Glu Gln Cys Trp Asn Gly Gly Phe Ile Tyr Leu Ile Met Leu 
                165                 170                 175


Arg Arg Phe Lys His Lys Ala His Ser Thr Tyr Asn Gly Asn Ser Ser 
            180                 185                 190


Asn Ser Ser Glu Pro Gly Glu Thr Pro Thr Leu Glu Leu Gly Asp Arg 
        195                 200                 205


Thr Ala Lys Lys Gly Lys Arg Thr Arg Lys Phe Gly Val Ile Ser Arg 
    210                 215                 220


Pro Pro Ala Asn Lys Ala Pro Glu Glu Ser Lys Gly Ser Ala Gly Cys 
225                 230                 235                 240


Glu Val Ser Ser Asp Pro Ser Thr Glu Leu Glu Asn Gly Pro Asp Pro 
                245                 250                 255


Glu Leu Gly Asn Gly His Val Phe Gln Leu Glu Asn Gly Pro Asp Ser 
            260                 265                 270


Leu Lys Glu Val Ala Gly Pro His Leu Glu Arg Ser Glu Val Asp Arg 
        275                 280                 285


Gly Thr Glu His Arg Ile Pro Lys Thr Asp Ala Pro Leu Thr Thr Ser 
    290                 295                 300


Asn Asp Lys Arg Arg Phe Ser Lys Gly Gly Lys Thr Asp Phe Gln Ser 
305                 310                 315                 320


Ser Asp Cys Leu Ala Arg Glu Glu Val Gly Arg Ile Trp Lys Met Glu 
                325                 330                 335


Leu Leu Lys Glu Ser Asp Gly Leu Gly Ile Gln Val Ser Gly Gly Arg 
            340                 345                 350


Gly Ser Lys Arg Ser Pro His Ala Ile Val Val Thr Gln Val Lys Glu 
        355                 360                 365


Gly Gly Ala Ala His Arg Asp Gly Arg Leu Ser Leu Gly Asp Glu Leu 
    370                 375                 380


Leu Val Ile Asn Gly His Leu Leu Val Gly Leu Ser His Glu Glu Ala 
385                 390                 395                 400


Val Ala Ile Leu Arg Ser Ala Thr Gly Met Val Gln Leu Val Val Ala 
                405                 410                 415


Ser Lys Glu Asn Ser Ala Glu Asp Leu Leu Arg Leu Thr Ser Lys Ser 
            420                 425                 430


Leu Pro Asp Leu Thr Ser Ser Val Glu Asp Val Ser Ser Trp Thr Asp 
        435                 440                 445


Asn Glu Asp Gln Glu Ala Asp Gly Glu Glu Asp Glu Gly Thr Ser Ser 
    450                 455                 460


Ser Val Gln Arg Ala Met Pro Gly Thr Asp Glu Pro Gln Asp Val Cys 
465                 470                 475                 480


Gly Ala Glu Glu Ser Lys Gly Asn Leu Glu Ser Pro Lys Gln Gly Ser 
                485                 490                 495


Asn Lys Ile Lys Leu Lys Ser Arg Leu Ser Gly Gly Val His Arg Leu 
            500                 505                 510


Glu Ser Val Glu Glu Tyr Asn Glu Leu Met Val Arg Asn Gly Asp Pro 
        515                 520                 525


Arg Ile Arg Met Leu Glu Val Ser Arg Asp Gly Arg Lys His Ser Leu 
    530                 535                 540


Pro Gln Leu Leu Asp Ser Ser Ser Ala Ser Gln Glu Tyr His Ile Val 
545                 550                 555                 560


Lys Lys Ser Thr Arg Ser Leu Ser Thr Thr Gln Val Glu Ser Pro Trp 
                565                 570                 575


Arg Leu Ile Arg Pro Ser Val Ile Ser Ile Ile Gly Leu Tyr Lys Glu 
            580                 585                 590


Lys Gly Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly Arg Asp Cys Ile 
        595                 600                 605


Arg Gly Gln Met Gly Ile Phe Val Lys Thr Ile Phe Pro Asn Gly Ser 
    610                 615                 620


Ala Ala Glu Asp Gly Arg Leu Lys Glu Gly Asp Glu Ile Leu Asp Val 
625                 630                 635                 640


Asn Gly Ile Pro Ile Lys Gly Leu Thr Phe Gln Glu Ala Ile His Thr 
                645                 650                 655


Phe Lys Gln Ile Arg Ser Gly Leu Phe Val Leu Thr Val Arg Thr Lys 
            660                 665                 670


Leu Val Ser Pro Ser Leu Thr Pro Cys Ser Thr Pro Thr His Met Ser 
        675                 680                 685


Arg Ser Ala Ser Pro Asn Phe Asn Thr Ser Gly Gly Ala Ser Ala Gly 
    690                 695                 700


Gly Ser Asp Glu Gly Ser Ser Ser Ser Leu Gly Arg Lys Thr Pro Gly 
705                 710                 715                 720


Pro Lys Asp Arg Ile Val Met Glu Val Thr Leu Asn Lys Glu Pro Arg 
                725                 730                 735


Val Gly Leu Gly Ile Gly Ala Cys Cys Leu Ala Leu Glu Asn Ser Pro 
            740                 745                 750


Pro Gly Ile Tyr Ile His Ser Leu Ala Pro Gly Ser Val Ala Lys Met 
        755                 760                 765


Glu Ser Asn Leu Ser Arg Gly Asp Gln Ile Leu Glu Val Asn Ser Val 
    770                 775                 780


Asn Val Arg His Ala Ala Leu Ser Lys Val His Ala Ile Leu Ser Lys 
785                 790                 795                 800


Cys Pro Pro Gly Pro Val Arg Leu Val Ile Gly Arg His Pro Asn Pro 
                805                 810                 815


Lys Val Ser Glu Gln Glu Met Asp Glu Val Ile Ala Arg Ser Thr Tyr 
            820                 825                 830


Gln Glu Ser Lys Glu Ala Asn Ser Ser Pro Gly Leu Gly Thr Pro Leu 
        835                 840                 845


Lys Ser Pro Ser Leu Ala Lys Lys Asp Ser Leu Ile Ser Glu Ser Glu 
    850                 855                 860


Leu Ser Gln Tyr Phe Ala His Asp Val Pro Gly Pro Leu Ser Asp Phe 
865                 870                 875                 880


Met Val Ala Gly Ser Glu Asp Glu Asp His Pro Gly Ser Gly Cys Ser 
                885                 890                 895


Thr Ser Glu Glu Gly Ser Leu Pro Pro Ser Thr Ser Thr His Lys Glu 
            900                 905                 910


Pro Gly Lys Pro Arg Ala Asn Ser Leu Val Thr Leu Gly Ser His Arg 
        915                 920                 925


Ala Ser Gly Leu Phe His Lys Gln Val Thr Val Ala Arg Gln Ala Ser 
    930                 935                 940


Leu Pro Gly Ser Pro Gln Ala Leu Arg Asn Pro Leu Leu Arg Gln Arg 
945                 950                 955                 960


Lys Val Gly Cys Tyr Asp Ala Asn Asp Ala Ser Asp Glu Glu Glu Phe 
                965                 970                 975


Asp Arg Glu Gly Asp Cys Ile Ser Leu Pro Gly Ala Leu Pro Gly Pro 
            980                 985                 990


Ile Arg Pro Leu Ser Glu Asp Asp Pro Arg Arg Val Ser Ile Ser Ser 
        995                 1000                1005


Ser Lys Gly Met Asp Val His Asn Gln Glu Glu Arg Pro Arg Lys Thr 
    1010                1015                1020


Leu Val Ser Lys Ala Ile Ser Ala Pro Leu Leu Gly Ser Ser Val Asp 
1025                1030                1035                1040


Leu Glu Glu Ser Ile Pro Glu Gly Met Val Asp Ala Ala Ser Tyr Ala 
                1045                1050                1055


Ala Asn Leu Thr Asp Ser Ala Glu Ala Pro Lys Gly Ser Pro Gly Ser 
            1060                1065                1070


Trp Trp Lys Lys Glu Leu Ser Gly Ser Ser Ser Ala Pro Lys Leu Glu 
        1075                1080                1085


Tyr Thr Val Arg Thr Asp Thr Gln Ser Pro Thr Asn Thr Gly Ser Pro 
    1090                1095                1100


Ser Ser Pro Gln Gln Lys Ser Glu Gly Leu Gly Ser Arg His Arg Pro 
1105                1110                1115                1120


Val Ala Arg Val Ser Pro His Cys Lys Arg Ser Glu Ala Glu Ala Lys 
                1125                1130                1135


Pro Ser Gly Ser Gln Thr Val Asn Leu Thr Gly Arg Ala Asn Asp Pro 
            1140                1145                1150


Cys Asp Leu Asp Ser Arg Val Gln Ala Thr Ser Val Lys Val Thr Val 
        1155                1160                1165


Ala Gly Phe Gln Pro Gly Gly Ala Val Glu Lys Glu Ser Leu Gly Lys 
    1170                1175                1180


Leu Thr Thr Gly Asp Ala Cys Val Ser Thr Ser Cys Glu Leu Ala Ser 
1185                1190                1195                1200


Ala Leu Ser His Leu Asp Ala Ser His Leu Thr Glu Asn Leu Pro Lys 
                1205                1210                1215


Ala Ala Ser Glu Leu Gly Gln Gln Pro Met Thr Glu Leu Asp Ser Ser 
            1220                1225                1230


Ser Asp Leu Ile Ser Ser Pro Gly Lys Lys Gly Ala Ala His Pro Asp 
        1235                1240                1245


Pro Ser Lys Thr Ser Val Asp Thr Gly Gln Val Ser Arg Pro Glu Asn 
    1250                1255                1260


Pro Ser Gln Pro Ala Ser Pro Arg Val Thr Lys Cys Lys Ala Arg Ser 
1265                1270                1275                1280


Pro Val Arg Leu Pro His Glu Gly Ser Pro Ser Pro Gly Glu Lys Ala 
                1285                1290                1295


Ala Ala Pro Pro Asp Tyr Ser Lys Thr Arg Ser Ala Ser Glu Thr Ser 
            1300                1305                1310


Thr Pro His Asn Thr Arg Arg Val Ala Ala Leu Arg Gly Ala Gly Pro 
        1315                1320                1325


Gly Ala Glu Gly Met Thr Pro Ala Gly Ala Val Leu Pro Gly Asp Pro 
    1330                1335                1340


Leu Thr Ser Gln Glu Gln Arg Gln Gly Ala Pro Gly Asn His Ser Lys 
1345                1350                1355                1360


Ala Leu Glu Met Thr Gly Ile His Ala Pro Glu Ser Ser Gln Glu Pro 
                1365                1370                1375


Ser Leu Leu Glu Gly Ala Asp Ser Val Ser Ser Arg Ala Pro Gln Ala 
            1380                1385                1390


Ser Leu Ser Met Leu Pro Ser Thr Asp Asn Thr Lys Glu Ala Cys Gly 
        1395                1400                1405


His Val Ser Gly His Cys Cys Pro Gly Gly Ser Arg Glu Ser Pro Val 
    1410                1415                1420


Thr Asp Ile Asp Ser Phe Ile Lys Glu Leu Asp Ala Ser Ala Ala Arg 
1425                1430                1435                1440


Ser Pro Ser Ser Gln Thr Gly Asp Ser Gly Ser Gln Glu Gly Ser Ala 
                1445                1450                1455


Gln Gly His Pro Pro Ala Gly Ala Gly Gly Gly Ser Ser Cys Arg Ala 
            1460                1465                1470


Glu Pro Val Pro Gly Gly Gln Thr Ser Ser Pro Arg Arg Ala Trp Ala 
        1475                1480                1485


Ala Gly Ala Pro Ala Tyr Pro Gln Trp Ala Ser Gln Pro Ser Val Leu 
    1490                1495                1500


Asp Ser Ile Asn Pro Asp Lys His Phe Thr Val Asn Lys Asn Phe Leu 
1505                1510                1515                1520


Ser Asn Tyr Ser Arg Asn Phe Ser Ser Phe His Glu Asp Ser Thr Ser 
                1525                1530                1535


Leu Ser Gly Leu Gly Asp Ser Thr Glu Pro Ser Leu Ser Ser Met Tyr 
            1540                1545                1550


Gly Asp Ala Glu Asp Ser Ser Ser Asp Pro Glu Ser Leu Thr Glu Ala 
        1555                1560                1565


Pro Arg Ala Ser Ala Arg Asp Gly Trp Ser Pro Pro Arg Ser Arg Val 
    1570                1575                1580


Ser Leu His Lys Glu Asp Pro Ser Glu Ser Glu Glu Glu Gln Ile Glu 
1585                1590                1595                1600


Ile Cys Ser Thr Arg Gly Cys Pro Asn Pro Pro Ser Ser Pro Ala His 
                1605                1610                1615


Leu Pro Thr Gln Ala Ala Ile Cys Pro Ala Ser Ala Lys Val Leu Ser 
            1620                1625                1630


Leu Lys Tyr Ser Thr Pro Arg Glu Ser Val Ala Ser Pro Arg Glu Lys 
        1635                1640                1645


Ala Ala Cys Leu Pro Gly Ser Tyr Thr Ser Gly Pro Asp Ser Ser Gln 
    1650                1655                1660


Pro Ser Ser Leu Leu Glu Met Ser Ser Gln Glu His Glu Thr His Ala 
1665                1670                1675                1680


Asp Ile Ser Thr Ser Gln Asn His Arg Pro Ser Cys Ala Glu Glu Thr 
                1685                1690                1695


Thr Glu Val Thr Ser Ala Ser Ser Ala Met Glu Asn Ser Pro Leu Ser 
            1700                1705                1710


Lys Val Ala Arg His Phe His Ser Pro Pro Ile Ile Leu Ser Ser Pro 
        1715                1720                1725


Asn Met Val Asn Gly Leu Glu His Asp Leu Leu Asp Asp Glu Thr Leu 
    1730                1735                1740


Asn Gln Tyr Glu Thr Ser Ile Asn Ala Ala Ala Ser Leu Ser Ser Phe 
1745                1750                1755                1760


Ser Val Asp Val Pro Lys Asn Gly Glu Ser Val Leu Glu Asn Leu His 
                1765                1770                1775


Ile Ser Glu Ser Gln Asp Leu Asp Asp Leu Leu Gln Lys Pro Lys Met 
            1780                1785                1790


Ile Ala Arg Arg Pro Ile Met Ala Trp Phe Lys Glu Ile Asn Lys His 
        1795                1800                1805


Asn Gln Gly Thr His Leu Arg Ser Lys Thr Glu Lys Glu Gln Pro Leu 
    1810                1815                1820


Met Pro Ala Arg Ser Pro Asp Ser Lys Ile Gln Met Val Ser Ser Ser 
1825                1830                1835                1840


Gln Lys Lys Gly Val Thr Val Pro His Ser Pro Pro Gln Pro Lys Thr 
                1845                1850                1855


Asn Leu Glu Asn Lys Asp Leu Ser Lys Lys Ser Pro Ala Glu Met Leu 
            1860                1865                1870


Leu Thr Asn Gly Gln Lys Ala Lys Cys Gly Pro Lys Leu Lys Arg Leu 
        1875                1880                1885


Ser Leu Lys Gly Lys Ala Lys Val Asn Ser Glu Ala Pro Ala Ala Asn 
    1890                1895                1900


Ala Val Lys Ala Gly Gly Thr Asp His Arg Lys Pro Leu Ile Ser Pro 
1905                1910                1915                1920


Gln Thr Ser His Lys Thr Leu Ser Lys Ala Val Ser Gln Arg Leu His 
                1925                1930                1935


Val Ala Asp His Glu Asp Pro Asp Arg Asn Thr Thr Ala Ala Pro Arg 
            1940                1945                1950


Ser Pro Gln Cys Val Leu Glu Ser Lys Pro Pro Leu Ala Thr Ser Gly 
        1955                1960                1965


Pro Leu Lys Pro Ser Val Ser Asp Thr Ser Ile Arg Thr Phe Val Ser 
    1970                1975                1980


Pro Leu Thr Ser Pro Lys Pro Val Pro Glu Gln Gly Met Trp Ser Arg 
1985                1990                1995                2000


Phe His Met Ala Val Leu Ser Glu Pro Asp Arg Gly Cys Pro Thr Thr 
                2005                2010                2015


Pro Lys Ser Pro Lys Cys Arg Ala Glu Gly Arg Ala Pro Arg Ala Asp 
            2020                2025                2030


Ser Gly Pro Val Ser Pro Ala Ala Ser Arg Asn Gly Met Ser Val Ala 
        2035                2040                2045


Gly Asn Arg Gln Ser Glu Pro Arg Leu Ala Ser His Val Ala Ala Asp 
    2050                2055                2060


Thr Ala Gln Pro Arg Pro Thr Gly Glu Lys Gly Gly Asn Ile Met Ala 
2065                2070                2075                2080


Ser Asp Arg Leu Glu Arg Thr Asn Gln Leu Lys Ile Val Glu Ile Ser 
                2085                2090                2095


Ala Glu Ala Val Ser Glu Thr Val Cys Gly Asn Lys Pro Ala Glu Ser 
            2100                2105                2110


Asp Arg Arg Gly Gly Cys Leu Ala Gln Gly Asn Cys Gln Glu Lys Ser 
        2115                2120                2125


Glu Ile Arg Leu Tyr Arg Gln Val Ala Glu Ser Ser Thr Ser His Pro 
    2130                2135                2140


Ser Ser Leu Pro Ser His Ala Ser Gln Ala Glu Gln Glu Met Ser Arg 
2145                2150                2155                2160


Ser Phe Ser Met Ala Lys Leu Ala Ser Ser Ser Ser Ser Leu Gln Thr 
                2165                2170                2175


Ala Ile Arg Lys Ala Glu Tyr Ser Gln Gly Lys Ser Ser Leu Met Ser 
            2180                2185                2190


Asp Ser Arg Gly Val Pro Arg Asn Ser Ile Pro Gly Gly Pro Ser Gly 
        2195                2200                2205


Glu Asp His Leu Tyr Phe Thr Pro Arg Pro Ala Thr Arg Thr Tyr Ser 
    2210                2215                2220


Met Pro Ala Gln Phe Ser Ser His Phe Gly Arg Glu Gly His Pro Pro 
2225                2230                2235                2240


His Ser Leu Gly Arg Ser Arg Asp Ser Gln Val Pro Val Thr Ser Ser 
                2245                2250                2255


Val Val Pro Glu Ala Lys Ala Ser Arg Gly Gly Leu Pro Ser Leu Ala 
            2260                2265                2270


Asn Gly Gln Gly Ile Tyr Ser Val Lys Pro Leu Leu Asp Thr Ser Arg 
        2275                2280                2285


Asn Leu Pro Ala Thr Asp Glu Gly Asp Ile Ile Ser Val Gln Glu Thr 
    2290                2295                2300


Ser Cys Leu Val Thr Asp Lys Ile Lys Val Thr Arg Arg His Tyr Cys 
2305                2310                2315                2320


Tyr Glu Gln Asn Trp Pro His Glu Ser Thr Ser Phe Phe Ser Val Lys 
                2325                2330                2335


Gln Arg Ile Lys Ser Phe Glu Asn Leu Ala Asn Ala Asp Arg Pro Val 
            2340                2345                2350


Ala Lys Ser Gly Ala Ser Pro Phe Leu Ser Val Ser Ser Lys Pro Pro 
        2355                2360                2365


Ile Gly Arg Arg Ser Ser Gly Ser Ile Val Ser Gly Ser Leu Gly His 
    2370                2375                2380


Pro Gly Asp Ala Ala Ala Arg Leu Leu Arg Arg Ser Leu Ser Ser Cys 
2385                2390                2395                2400


Ser Glu Asn Gln Ser Glu Ala Gly Thr Leu Leu Pro Gln Met Ala Lys 
                2405                2410                2415


Ser Pro Ser Ile Met Thr Leu Thr Ile Ser Arg Gln Asn Pro Pro Glu 
            2420                2425                2430


Thr Ser Ser Lys Gly Ser Asp Ser Glu Leu Lys Lys Ser Leu Gly Pro 
        2435                2440                2445


Leu Gly Ile Pro Thr Pro Thr Met Thr Leu Ala Ser Pro Val Lys Arg 
    2450                2455                2460


Asn Lys Ser Ser Val Arg His Thr Gln Pro Ser Pro Val Ser Arg Ser 
2465                2470                2475                2480


Lys Leu Gln Glu Leu Arg Ala Leu Ser Met Pro Asp Leu Asp Lys Leu 
                2485                2490                2495


Cys Ser Glu Asp Tyr Ser Ala Gly Pro Ser Ala Val Leu Phe Lys Thr 
            2500                2505                2510


Glu Leu Glu Ile Thr Pro Arg Arg Ser Pro Gly Pro Pro Ala Gly Gly 
        2515                2520                2525


Val Ser Cys Pro Glu Lys Gly Gly Asn Arg Ala Cys Pro Gly Gly Ser 
    2530                2535                2540


Gly Pro Lys Thr Ser Ala Ala Glu Thr Pro Ser Ser Ala Ser Asp Thr 
2545                2550                2555                2560


Gly Glu Ala Ala Gln Asp Leu Pro Phe Arg Arg Ser Trp Ser Val Asn 
                2565                2570                2575


Leu Asp Gln Leu Leu Val Ser Ala Gly Asp Gln Gln Arg Leu Gln Ser 
            2580                2585                2590


Val Leu Ser Ser Val Gly Ser Lys Ser Thr Ile Leu Thr Leu Ile Gln 
        2595                2600                2605


Glu Ala Lys Ala Gln Ser Glu Asn Glu Glu Asp Val Cys Phe Ile Val 
    2610                2615                2620


Leu Asn Arg Lys Glu Gly Ser Gly Leu Gly Phe Ser Val Ala Gly Gly 
2625                2630                2635                2640


Thr Asp Val Glu Pro Lys Ser Ile Thr Val His Arg Val Phe Ser Gln 
                2645                2650                2655


Gly Ala Ala Ser Gln Glu Gly Thr Met Asn Arg Gly Asp Phe Leu Leu 
            2660                2665                2670


Ser Val Asn Gly Ala Ser Leu Ala Gly Leu Ala His Gly Asn Val Leu 
        2675                2680                2685


Lys Val Leu His Gln Ala Gln Leu His Lys Asp Ala Leu Val Val Ile 
    2690                2695                2700


Lys Lys Gly Met Asp Gln Pro Arg Pro Ser Ala Arg Gln Glu Pro Pro 
2705                2710                2715                2720


Thr Ala Asn Gly Lys Gly Leu Leu Ser Arg Lys Thr Ile Pro Leu Glu 
                2725                2730                2735


Pro Gly Ile Gly Arg Ser Val Ala Val His Asp Ala Leu Cys Val Glu 
            2740                2745                2750


Val Leu Lys Thr Ser Ala Gly Leu Gly Leu Ser Leu Asp Gly Gly Lys 
        2755                2760                2765


Ser Ser Val Thr Gly Asp Gly Pro Leu Val Ile Lys Arg Val Tyr Lys 
    2770                2775                2780


Gly Gly Ala Ala Glu Gln Ala Gly Ile Ile Glu Ala Gly Asp Glu Ile 
2785                2790                2795                2800


Leu Ala Ile Asn Gly Lys Pro Leu Val Gly Leu Met His Phe Asp Ala 
                2805                2810                2815


Trp Asn Ile Met Lys Ser Val Pro Glu Gly Pro Val Gln Leu Leu Ile 
            2820                2825                2830


Arg Lys His Arg Asn Ser Ser 
        2835


<210>  2636
<211>  4304
<212>  DNA
<213>  Homo sapiens

<400>  2636
tttggacggg agggtcaccc cccacacagc ctgggtcgct ctcgggacag ccaggtccct     60

gtgacaagca gtgttgtccc cgaggcaaag gcatccagag gtggtcttcc cagcctggct    120

aatggacagg gcatatatag tgtaaagccg ctgctggaca catcgaggaa tcttccagcc    180

acagatgaag gggatatcat ttcagtccag gagacgagct gcctagtcac agacaaaatc    240

aaagtcacca gacgacacta ctgctatgag cagaactggc cccatgaatc tacctcattt    300

ttctctgtga agcagcggat caagtctttt gagaacctgg ccaatgctga ccggcctgta    360

gccaagtccg gggcttcccc atttttgtcg gtgagctcca agcctcccat tgggaggcgg    420

tcttccggca gcattgtttc cgggagcctg ggccacccag gtgacgcagc agcaaggttg    480

ttgagacgca gcttgagttc ctgcagcgaa aaccaaagcg aagccggcac cctcctgccc    540

cagatggcca agtctccctc aatcatgaca ctgaccatct ctcggcagaa cccaccagag    600

accagtagca agggctctga ttcggaacta aagaaatcac ttggtccttt gggaattccc    660

accccaacga tgaccctggc ttctcctgtt aagaggaaca agtcctcggt acgccacacg    720

cagccctcgc ccgtgtcccg ctccaagctc caggagctga gagccttgag catgcctgac    780

cttgacaagc tctgcagcga ggattactca gcagggccga gcgccgtgct cttcaaaact    840

gagctggaga tcacccccag gaggtcacct ggccctcctg ctggaggcgt ttcgtgtccc    900

gagaagggcg ggaacagggc ctgtccagga ggaagtggcc ctaaaaccag tgctgctgag    960

acacccagtt cagccagtga tacgggtgaa gctgcccagg atctgccttt tagaagaagc   1020

tggtcagtta atttggatca acttctagtc tcagcggggg accagcaaag attacagtct   1080

gttttatcgt cagtgggatc gaaatctacc atcctaactc tcattcagga agcgaaagca   1140

caatcagaga atgaagaaga tgtttgcttc atagtcttga atagaaaaga aggctcaggt   1200

ctgggattca gttgtggctg tacacgatgc tctgtgtgtt gaagtgctga agacctcggc   1260

tgggctggga ctgagtctgg atgggggaaa atcatcggtg acgggagatg ggcccttggt   1320

cattaaaaga gtgtacaaag gtggtgcggc tgaacaagct ggaataatag aagctggaga   1380

tgaaattctt gctattaatg ggaaacctct ggttgggctc atgcactttg atgcctggaa   1440

tattatgaag tctgtcccag aaggacctgt gcagttatta attagaaagc ataggaattc   1500

ttcatgaatt ttaacaagaa tcattttctc agttctcttc tttctttagc aaatcagagt   1560

gacttcttta aaccacaggt tgttgaaatg gccaacactg gtacagacac ggactataaa   1620

aatctccaag cttgtgctta cacatgaagc ctgacttaac tgtatgtgca acagcaatga   1680

aattaactcc agaagccttc cacctgcgtc acccaggccg ggagggttcc ttcgttccag   1740

tgcctgtccc ctacctttat gttatgttta ctgatgggga tacaagatgt gacacaccct   1800

tctttatttg aaacaaacaa acatttagct agacctttgc ttccttcttg ccagctctcc   1860

caacataccc aatcctggtg atcagggaac taaaagtctg agggggacac aaatgtcaca   1920

cctaagagga caatcaatca ttttgtatga ttttgtaagt aaatgacaga atgcttttag   1980

gcacattcaa tggaaggagg agatgtaggt ctgtatatgt taccctgaaa agagaataag   2040

acttacttaa aaaaatgaat tatgacctgt taggctgagc tcaggaattg tccaaaaagg   2100

aaaaagcaaa ataattaatt gagagtattt tttagtgagt gtaatgtata atgtacgtat   2160

gcaaagttca actcaatagg ttattgatca ccatgaagta ttgatcattt tctatctcaa   2220

aagtgtaagc cataaggctg ttttacagaa tagcacttct gataagctgt attaaatagc   2280

catgagcttc actgcttaga gggagcagaa aggtcaacat ctaaaagcac cttacaacta   2340

gtttttgaac ctgtcttgat aagtgcttga attcaagact ggtcagtcca agagcagaca   2400

aaaatatcac aagtcagtca gtcactgggt ttccatttct gaattttatg cactccaacc   2460

atgaatttaa actaaatttt tagaaatcaa gtatctttct aagtgtcctt ggatttatag   2520

acaatgtatg tacaatccaa atagaggagc ttaatggaat ccttttagga gactggttgg   2580

tttttttccc tctttcccaa catgtttaag aaatgtaaca ttctaagtat tggatctctt   2640

ttcttgacct agtataatga caactgcagt gacttaagtt tttgctgttt tcgttttccc   2700

gctttgcaat ttcctccttt tgccaaaaat gttttcctac agaagactgt cgtgactcac   2760

gctacttggg aaactcactc tggccactcc tcctctggtg gcatgagctg cttcccagta   2820

gctattccga ttggatattc cgttcgtcgt cacatagctg gcttttctct cctcatgatg   2880

taccttattt tcttaggtaa ataattccaa actctcatcg ggtcataaag aggaggagaa   2940

acagggtgag tcaaggtaaa ggagcagaaa tgtagttaca agccaggtcg tcttcagtgg   3000

cacaaaccaa cccgttgagc cctgacaaca tgagtggaga gtgcatttgc catacctgtg   3060

tgcatgacac taagatttta tgttggagat acttctttaa ataacctaca gcttgggtct   3120

atggctgtga cccccagatt catggagggg ctttagccat cagctttgta catcatcatt   3180

tttctgaatg accaatccca ctaaacatct ttgaagtcgg cctagagagg tccttcagat   3240

gagagagaaa tagctggctt gtctgagtcc agatttctca tcaactggca atacaaagga   3300

aaatatggta caggagttag ttagaaaggt cttattgatt ttacttctac ttttcactac   3360

agttacaggt agaatactgt aggaagtcag tgcaaggtgc atgcttgatt gatagatatt   3420

gattgattgt ttttcagtct ctggggtcag ttttgtggtt tctgctttct tgcctaaatc   3480

aaagactatt tcaagtcaac aacactgaaa actgcttttc gcctccactc ttacagctgt   3540

gcctaataat aattaattaa taaacgcaca gccctatgtg aacagacagg aatttcttgt   3600

gcaatgtgga gcaaatggaa tggtctcctt ccgcaagtct ttttaatcct catatctgga   3660

gtacaagggt agacctctgg cttaccacat acactatgct aaagtcatca gccactgcta   3720

ctacatcttg ccagaaggtt tccctcgcca acaaacagtt gaaatttaag ggaagaagca   3780

aaagctaaac tgtctttgac cctaagatag atagaaagct atttatttgt cttcagtgtt   3840

caaggcatga ctagtatttc taattagcct aataaattcc cacactttct gaagtgaaca   3900

ctaatggtat tgtcctacta aaactgtcat tgtttctttt tttttaactg gtcagtcatt   3960

cacaataagc tatgagggta aataaatatg tgttataaca agtaaaccgt agttgcaaga   4020

atataccatg aagattaaag taggctgggt ttcatttcca tcttcccaca catctcattg   4080

aatttgatgg ttgacttaat tggcaccata actttgtatg atattataca ttaaccttta   4140

tttatgtaaa gtaaaatgcc ttatatatta aagagtaagt gcaataatat gaaatagcct   4200

gtacatttta aaaatgttgt caccaagtta tataaatcca catctctgta aacaaccttt   4260

tttaagtaat tttaaaaaaa ataaacactc tgcttactac ttga                    4304


<210>  2637
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  2637

Met Ala Lys Ser Pro Ser Ile Met Thr Leu Thr Ile Ser Arg Gln Asn 
1               5                   10                  15


Pro Pro Glu Thr Ser Ser Lys Gly Ser Asp Ser Glu Leu Lys Lys Ser 
            20                  25                  30


Leu Gly Pro Leu Gly Ile Pro Thr Pro Thr Met Thr Leu Ala Ser Pro 
        35                  40                  45


Val Lys Arg Asn Lys Ser Ser Val Arg His Thr Gln Pro Ser Pro Val 
    50                  55                  60


Ser Arg Ser Lys Leu Gln Glu Leu Arg Ala Leu Ser Met Pro Asp Leu 
65                  70                  75                  80


Asp Lys Leu Cys Ser Glu Asp Tyr Ser Ala Gly Pro Ser Ala Val Leu 
                85                  90                  95


Phe Lys Thr Glu Leu Glu Ile Thr Pro Arg Arg Ser Pro Gly Pro Pro 
            100                 105                 110


Ala Gly Gly Val Ser Cys Pro Glu Lys Gly Gly Asn Arg Ala Cys Pro 
        115                 120                 125


Gly Gly Ser Gly Pro Lys Thr Ser Ala Ala Glu Thr Pro Ser Ser Ala 
    130                 135                 140


Ser Asp Thr Gly Glu Ala Ala Gln Asp Leu Pro Phe Arg Arg Ser Trp 
145                 150                 155                 160


Ser Val Asn Leu Asp Gln Leu Leu Val Ser Ala Gly Asp Gln Gln Arg 
                165                 170                 175


Leu Gln Ser Val Leu Ser Ser Val Gly Ser Lys Ser Thr Ile Leu Thr 
            180                 185                 190


Leu Ile Gln Glu Ala Lys Ala Gln Ser Glu Asn Glu Glu Asp Val Cys 
        195                 200                 205


Phe Ile Val Leu Asn Arg Lys Glu Gly Ser Gly Leu Gly Phe Ser Cys 
    210                 215                 220


Gly Cys Thr Arg Cys Ser Val Cys 
225                 230


<210>  2638
<211>  851
<212>  DNA
<213>  Homo sapiens

<400>  2638
acctgggaac gtgaaacggt gtctggcccc cactgcggca tttctgattt aattaagctg     60

ggaatttcct gggcatcagg aatttaaaag cgtcccagca tctctactgt gcagaacctt    120

caggacattc ccgtgggcta agccagccag tgaggcgccg ttgactgaca gaaggaaatc    180

ccctcggttc atagtccctt cctgagaagc cgccccctga gaaaacaccc tgtggacctg    240

ggatgaggaa aggaaaaggg aacaaaaacc agatccactt acgatttccg tgtctgacat    300

gggcctggca tccaggaggc aatgggaata cgaagatgaa tgaggcctgg gctcgtgcag    360

tgaaggtgac cctctggatg gtcctgaagg cttttgaatg atgtaaaatt ttgagtgact    420

ttttgagacg ggagtaattg tataaacaca agtttggcca gttgattcta atgttttcta    480

ctgcttaaaa tatggaggta aattataagg ctatagcgaa ttgtgtttat agggattgga    540

aatggcctat acatgtcagc tctgtgttaa aaatgcttgt cttttgtcaa cgaaaacctt    600

acgtactact tctcccactt ctcccttttt atgttggtag ctgggaatga aatccagcaa    660

tctctgaacc cgctgattgg aatttgtgcc ctgatcacat tctgaggctg cttgaggggg    720

gattttcctg agagcctaat gactctgtca cttaccgtga ttgattttgg ctccacatct    780

gtccctcctg ccacactgaa tcccagacct gagccttctt ttctattcaa gactatgaag    840

caaacatctt c                                                         851


<210>  2639
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  2639

Met Arg Lys Gly Lys Gly Asn Lys Asn Gln Ile His Leu Arg Phe Pro 
1               5                   10                  15


Cys Leu Thr Trp Ala Trp His Pro Gly Gly Asn Gly Asn Thr Lys Met 
            20                  25                  30


Asn Glu Ala Trp Ala Arg Ala Val Lys Val Thr Leu Trp Met Val Leu 
        35                  40                  45


Lys Ala Phe Glu 
    50


<210>  2640
<211>  4889
<212>  DNA
<213>  Homo sapiens

<400>  2640
atattcagag cctcagaacc acgtgcagcg tctgtttctg cagtgcgagc tgtttaatgc     60

cctgttaagt actgcagatg tctggagtgc cgtgcatctt ggcattcagg ggtgacgtct    120

ttttttattc gagagggcaa agcagagggt atgggttagg cagtgccttc tgggaggggc    180

cttttgttcc ttctccacat ctctccctga taagggtagc tggattcctt tctacaactt    240

ggcttccttg tggcctgagc tgtttgtagt ccttgctgaa aatggctccg attccattta    300

acaaatgaga aacacttctt gtccagatgc ctccatggtc cccagtcttc cttctgtgtc    360

atttcacttt ccctcttcca gagggctgag gccctcctca atacagggaa acaccttggt    420

catcagatct tgtcatgctt gcctttgccc caaaactgtc tcgaccactt ggtggacttt    480

cagtgggatc cttgtaaact gtcaaaggaa accacttcat cctcacagct gccagttttt    540

aagcctcgtg aactcagatc tggatggtcc ttctgtcatt tataatcaat cactcagtat    600

tcctgcagca acttcagggc ctctggtctt gaagcagacc ctgcagagca atcaatcaaa    660

cgctgagcgc ctggagggct taacctcgct cagtttcctg ttcttcagtc tccctaaccc    720

aggtctaccc ggtcctatgc agttatattc cttaccatac actgacagcg tccagctggg    780

ggcccggtgc agtaagctgc acagtagaga tgctgggacg cttttaaatt cctgatgccc    840

aggaaattcc cagcttaatt aaatcagaaa tgccgcagtg ggggccagac accgtttcac    900

gttcccaggt gactccagta tgcagccaga ctcgagccac tgcaatagac ccattttcct    960

gttgaaaaat catgctcccc ccagtgttag taaatgtcct tcagaccctg tggagtggcc   1020

ttctttaaac cacgacaatg gactggcctt tatgtccaaa ggagacaatg ctagcttggc   1080

ttcagcccta gtgaacagtg aacagaggaa gcaggcagtt taatccatcc gtggtccttc   1140

ctctgcctcc caattaacta agtgtgcctt tgcagtcaac tctgacgtcc ttggctggta   1200

ggcaggcaag ggagggaagt acaaggcaag tttacaatcc tgattcaaac cagcccacta   1260

tcccgaaacc agcacacaga gccggcatca ccatggaaac acatttcctc acagtggagc   1320

aagatgccag tagaggcagc gagtgtgttt gtgaagacag ccatagccag gggcagggtt   1380

tccctttgca ggagcaggag tggcaggagc ggggaggcag gaagctctct gggttcctgg   1440

gggctttgga gtccattcta acagtctcac atgagactgg gcattttggt gctgccaagt   1500

cttggtacca gaggatgatc tgctgctgcc attagcagcc agggttggca gaaaatcaaa   1560

tttggagtcc ccaagtgtga cttcagtcct cactgagaag tgcacagccg gtgtgggggg   1620

cttaacaaga gcactttgct ttctggggat ttctgcttgg gcataaaagc atttgccaat   1680

gcttgcagaa aacacagaac aaaggatgca agtacagcag caacacagcc aggagggcag   1740

ccccagaatt gggaggccaa cagtgctact gggctcaagt gctgttataa ggagaagtgt   1800

ggctgtacac gatgctctgt gtgttgaagt gctgaagacc tcggctgggc tgggactgag   1860

tctggatggg ggaaaatcat cggtgacggg agatgggccc ttggtcatta aaagagtgta   1920

caaaggtggt gcggctgaac aagctggaat aatagaagct ggagatgaaa ttcttgctat   1980

taatgggaaa cctctggttg ggctcatgca ctttgatgcc tggaatatta tgaagtctgt   2040

cccagaagga cctgtgcagt tattaattag aaagcatagg aattcttcat gaattttaac   2100

aagaatcatt ttctcagttc tcttctttct ttagcaaatc agagtgactt ctttaaacca   2160

caggttgttg aaatggccaa cactggtaca gacacggact ataaaaatct ccaagcttgt   2220

gcttacacat gaagcctgac ttaactgtat gtgcaacagc aatgaaatta actccagaag   2280

ccttccacct gcgtcaccca ggccgggagg gttccttcgt tccagtgcct gtcccctacc   2340

tttatgttat gtttactgat ggggatacaa gatgtgacac acccttcttt atttgaaaca   2400

aacaaacatt tagctagacc tttgcttcct tcttgccagc tctcccaaca tacccaatcc   2460

tggtgatcag ggaactaaaa gtctgagggg gacacaaatg tcacacctaa gaggacaatc   2520

aatcattttg tatgattttg taagtaaatg acagaatgct tttaggcaca ttcaatggaa   2580

ggaggagatg taggtctgta tatgttaccc tgaaaagaga ataagactta cttaaaaaaa   2640

tgaattatga cctgttaggc tgagctcagg aattgtccaa aaaggaaaaa gcaaaataat   2700

taattgagag tattttttag tgagtgtaat gtataatgta cgtatgcaaa gttcaactca   2760

ataggttatt gatcaccatg aagtattgat cattttctat ctcaaaagtg taagccataa   2820

ggctgtttta cagaatagca cttctgataa gctgtattaa atagccatga gcttcactgc   2880

ttagagggag cagaaaggtc aacatctaaa agcaccttac aactagtttt tgaacctgtc   2940

ttgataagtg cttgaattca agactggtca gtccaagagc agacaaaaat atcacaagtc   3000

agtcagtcac tgggtttcca tttctgaatt ttatgcactc caaccatgaa tttaaactaa   3060

atttttagaa atcaagtatc tttctaagtg tccttggatt tatagacaat gtatgtacaa   3120

tccaaataga ggagcttaat ggaatccttt taggagactg gttggttttt ttccctcttt   3180

cccaacatgt ttaagaaatg taacattcta agtattggat ctcttttctt gacctagtat   3240

aatgacaact gcagtgactt aagtttttgc tgttttcgtt ttcccgcttt gcaatttcct   3300

ccttttgcca aaaatgtttt cctacagaag actgtcgtga ctcacgctac ttgggaaact   3360

cactctggcc actcctcctc tggtggcatg agctgcttcc cagtagctat tccgattgga   3420

tattccgttc gtcgtcacat agctggcttt tctctcctca tgatgtacct tattttctta   3480

ggtaaataat tccaaactct catcgggtca taaagaggag gagaaacagg gtgagtcaag   3540

gtaaaggagc agaaatgtag ttacaagcca ggtcgtcttc agtggcacaa accaacccgt   3600

tgagccctga caacatgagt ggagagtgca tttgccatac ctgtgtgcat gacactaaga   3660

ttttatgttg gagatacttc tttaaataac ctacagcttg ggtctatggc tgtgaccccc   3720

agattcatgg aggggcttta gccatcagct ttgtacatca tcatttttct gaatgaccaa   3780

tcccactaaa catctttgaa gtcggcctag agaggtcctt cagatgagag agaaatagct   3840

ggcttgtctg agtccagatt tctcatcaac tggcaataca aaggaaaata tggtacagga   3900

gttagttaga aaggtcttat tgattttact tctacttttc actacagtta caggtagaat   3960

actgtaggaa gtcagtgcaa ggtgcatgct tgattgatag atattgattg attgtttttc   4020

agtctctggg gtcagttttg tggtttctgc tttcttgcct aaatcaaaga ctatttcaag   4080

tcaacaacac tgaaaactgc ttttcgcctc cactcttaca gctgtgccta ataataatta   4140

attaataaac gcacagccct atgtgaacag acaggaattt cttgtgcaat gtggagcaaa   4200

tggaatggtc tccttccgca agtcttttta atcctcatat ctggagtaca agggtagacc   4260

tctggcttac cacatacact atgctaaagt catcagccac tgctactaca tcttgccaga   4320

aggtttccct cgccaacaaa cagttgaaat ttaagggaag aagcaaaagc taaactgtct   4380

ttgaccctaa gatagataga aagctattta tttgtcttca gtgttcaagg catgactagt   4440

atttctaatt agcctaataa attcccacac tttctgaagt gaacactaat ggtattgtcc   4500

tactaaaact gtcattgttt cttttttttt aactggtcag tcattcacaa taagctatga   4560

gggtaaataa atatgtgtta taacaagtaa accgtagttg caagaatata ccatgaagat   4620

taaagtaggc tgggtttcat ttccatcttc ccacacatct cattgaattt gatggttgac   4680

ttaattggca ccataacttt gtatgatatt atacattaac ctttatttat gtaaagtaaa   4740

atgccttata tattaaagag taagtgcaat aatatgaaat agcctgtaca ttttaaaaat   4800

gttgtcacca agttatataa atccacatct ctgtaaacaa ccttttttaa gtaattttaa   4860

aaaaaataaa cactctgctt actacttga                                     4889


<210>  2641
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  2641

Met Leu Ala Glu Asn Thr Glu Gln Arg Met Gln Val Gln Gln Gln His 
1               5                   10                  15


Ser Gln Glu Gly Ser Pro Arg Ile Gly Arg Pro Thr Val Leu Leu Gly 
            20                  25                  30


Ser Ser Ala Val Ile Arg Arg Ser Val Ala Val His Asp Ala Leu Cys 
        35                  40                  45


Val Glu Val Leu Lys Thr Ser Ala Gly Leu Gly Leu Ser Leu Asp Gly 
    50                  55                  60


Gly Lys Ser Ser Val Thr Gly Asp Gly Pro Leu Val Ile Lys Arg Val 
65                  70                  75                  80


Tyr Lys Gly Gly Ala Ala Glu Gln Ala Gly Ile Ile Glu Ala Gly Asp 
                85                  90                  95


Glu Ile Leu Ala Ile Asn Gly Lys Pro Leu Val Gly Leu Met His Phe 
            100                 105                 110


Asp Ala Trp Asn Ile Met Lys Ser Val Pro Glu Gly Pro Val Gln Leu 
        115                 120                 125


Leu Ile Arg Lys His Arg Asn Ser Ser 
    130                 135


<210>  2642
<211>  3061
<212>  DNA
<213>  Homo sapiens

<400>  2642
acagaacaaa ggatgcaagt acagcagcaa cacagccagg agggcagccc cagaattggg     60

aggccaacag tgctactggg ctcaagtgct gttataagtg gtgcggctga acaagctgga    120

ataatagaag ctggagatga aattcttgct attaatggga aacctctggt tgggctcatg    180

cactttgatg cctggaatat tatgaagtct gtcccagaag gacctgtgca gttattaatt    240

agaaagcata ggaattcttc atgaatttta acaagaatca ttttctcagt tctcttcttt    300

ctttagcaaa tcagagtgac ttctttaaac cacaggttgt tgaaatggcc aacactggta    360

cagacacgga ctataaaaat ctccaagctt gtgcttacac atgaagcctg acttaactgt    420

atgtgcaaca gcaatgaaat taactccaga agccttccac ctgcgtcacc caggccggga    480

gggttccttc gttccagtgc ctgtccccta cctttatgtt atgtttactg atggggatac    540

aagatgtgac acacccttct ttatttgaaa caaacaaaca tttagctaga cctttgcttc    600

cttcttgcca gctctcccaa catacccaat cctggtgatc agggaactaa aagtctgagg    660

gggacacaaa tgtcacacct aagaggacaa tcaatcattt tgtatgattt tgtaagtaaa    720

tgacagaatg cttttaggca cattcaatgg aaggaggaga tgtaggtctg tatatgttac    780

cctgaaaaga gaataagact tacttaaaaa aatgaattat gacctgttag gctgagctca    840

ggaattgtcc aaaaaggaaa aagcaaaata attaattgag agtatttttt agtgagtgta    900

atgtataatg tacgtatgca aagttcaact caataggtta ttgatcacca tgaagtattg    960

atcattttct atctcaaaag tgtaagccat aaggctgttt tacagaatag cacttctgat   1020

aagctgtatt aaatagccat gagcttcact gcttagaggg agcagaaagg tcaacatcta   1080

aaagcacctt acaactagtt tttgaacctg tcttgataag tgcttgaatt caagactggt   1140

cagtccaaga gcagacaaaa atatcacaag tcagtcagtc actgggtttc catttctgaa   1200

ttttatgcac tccaaccatg aatttaaact aaatttttag aaatcaagta tctttctaag   1260

tgtccttgga tttatagaca atgtatgtac aatccaaata gaggagctta atggaatcct   1320

tttaggagac tggttggttt ttttccctct ttcccaacat gtttaagaaa tgtaacattc   1380

taagtattgg atctcttttc ttgacctagt ataatgacaa ctgcagtgac ttaagttttt   1440

gctgttttcg ttttcccgct ttgcaatttc ctccttttgc caaaaatgtt ttcctacaga   1500

agactgtcgt gactcacgct acttgggaaa ctcactctgg ccactcctcc tctggtggca   1560

tgagctgctt cccagtagct attccgattg gatattccgt tcgtcgtcac atagctggct   1620

tttctctcct catgatgtac cttattttct taggtaaata attccaaact ctcatcgggt   1680

cataaagagg aggagaaaca gggtgagtca aggtaaagga gcagaaatgt agttacaagc   1740

caggtcgtct tcagtggcac aaaccaaccc gttgagccct gacaacatga gtggagagtg   1800

catttgccat acctgtgtgc atgacactaa gattttatgt tggagatact tctttaaata   1860

acctacagct tgggtctatg gctgtgaccc ccagattcat ggaggggctt tagccatcag   1920

ctttgtacat catcattttt ctgaatgacc aatcccacta aacatctttg aagtcggcct   1980

agagaggtcc ttcagatgag agagaaatag ctggcttgtc tgagtccaga tttctcatca   2040

actggcaata caaaggaaaa tatggtacag gagttagtta gaaaggtctt attgatttta   2100

cttctacttt tcactacagt tacaggtaga atactgtagg aagtcagtgc aaggtgcatg   2160

cttgattgat agatattgat tgattgtttt tcagtctctg gggtcagttt tgtggtttct   2220

gctttcttgc ctaaatcaaa gactatttca agtcaacaac actgaaaact gcttttcgcc   2280

tccactctta cagctgtgcc taataataat taattaataa acgcacagcc ctatgtgaac   2340

agacaggaat ttcttgtgca atgtggagca aatggaatgg tctccttccg caagtctttt   2400

taatcctcat atctggagta caagggtaga cctctggctt accacataca ctatgctaaa   2460

gtcatcagcc actgctacta catcttgcca gaaggtttcc ctcgccaaca aacagttgaa   2520

atttaaggga agaagcaaaa gctaaactgt ctttgaccct aagatagata gaaagctatt   2580

tatttgtctt cagtgttcaa ggcatgacta gtatttctaa ttagcctaat aaattcccac   2640

actttctgaa gtgaacacta atggtattgt cctactaaaa ctgtcattgt ttcttttttt   2700

ttaactggtc agtcattcac aataagctat gagggtaaat aaatatgtgt tataacaagt   2760

aaaccgtagt tgcaagaata taccatgaag attaaagtag gctgggtttc atttccatct   2820

tcccacacat ctcattgaat ttgatggttg acttaattgg caccataact ttgtatgata   2880

ttatacatta acctttattt atgtaaagta aaatgcctta tatattaaag agtaagtgca   2940

ataatatgaa atagcctgta cattttaaaa atgttgtcac caagttatat aaatccacat   3000

ctctgtaaac aacctttttt aagtaatttt aaaaaaaata aacactctgc ttactacttg   3060

a                                                                   3061


<210>  2643
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  2643

Met Gln Val Gln Gln Gln His Ser Gln Glu Gly Ser Pro Arg Ile Gly 
1               5                   10                  15


Arg Pro Thr Val Leu Leu Gly Ser Ser Ala Val Ile Ser Gly Ala Ala 
            20                  25                  30


Glu Gln Ala Gly Ile Ile Glu Ala Gly Asp Glu Ile Leu Ala Ile Asn 
        35                  40                  45


Gly Lys Pro Leu Val Gly Leu Met His Phe Asp Ala Trp Asn Ile Met 
    50                  55                  60


Lys Ser Val Pro Glu Gly Pro Val Gln Leu Leu Ile Arg Lys His Arg 
65                  70                  75                  80


Asn Ser Ser 



<210>  2644
<211>  1049
<212>  DNA
<213>  Homo sapiens

<400>  2644
gcattgatct ttttatgtac tgattcacga ggacttaagc ctatgatgca gttgttttcc     60

cagtcttggg agctggcaga tgccattacc caggtcagga gatagaacct tgccagctat    120

accctgaagc tgttcaagtc tttctcccaa ttacagtctt cataagagtt gttagaagga    180

ctgaatgaga tgaagtagag gaaagtcttc taggacaggg gtcctcaacc cttgggccac    240

agactggtgg caggagggct gcacagcaga tgggatgcct ggttgcaaga aaacaagctc    300

agggctccca cagattctac gtgatgcagt tttcacagat ttgtggccag atgctagaga    360

caaaggctga gaagttgtcc aggacgtcat attcttgctt tgctggaggc agatctgaag    420

gatgtcatct ctcctgtggc ttcttctagt gtggggtccc gaagcctggc ttccccagcc    480

gatgtgctgc tttagtcagc gtctgccctg gtccttcggt tcgcaggctc acacgctttt    540

ttgggttgtg tccctttgga ctgcagaggc tacgtgtcct gtgaccaacc acgaaggcgg    600

ccactcccgc tcccctcagg agtgtcttaa aatacctcca ttttagctac cctattgaat    660

gacaggttag ctgggtgctg ggttttcagg tgatggacat tttccctcag tcctctgaag    720

gtgttgctgg cttcaggcat tgatgccgcc actctgattg ttgtatgcag tgagcaaact    780

agaattttct cttggctttc tagattttct tctttatatt ctgaaacttt attatatcaa    840

ggtttgaatt ttattttttt tggagacagg gtcctactct gtcatccagg ctggagtgca    900

atggtgcagt cctgctcact gcagcctcca agtccagggc tgaagcgatc cttctgcctc    960

agcctcctaa gtagctggga tcacaggtgt gcaccactct gcctaacaag gcttgttttt   1020

tgtttgtttg tttgttttaa ataaataca                                     1049


<210>  2645
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  2645

Met Gly Cys Leu Val Ala Arg Lys Gln Ala Gln Gly Ser His Arg Phe 
1               5                   10                  15


Tyr Val Met Gln Phe Ser Gln Ile Cys Gly Gln Met Leu Glu Thr Lys 
            20                  25                  30


Ala Glu Lys Leu Ser Arg Thr Ser Tyr Ser Cys Phe Ala Gly Gly Arg 
        35                  40                  45


Ser Glu Gly Cys His Leu Ser Cys Gly Phe Phe 
    50                  55


<210>  2646
<211>  632
<212>  DNA
<213>  Homo sapiens

<400>  2646
atatatcagc cagaatctgt taacaattag aagctgacag cctgggcaac atggcaagac     60

cccatctcta ccaaaaatat aaaaaaaaaa gctgtgcatg gtggtgtatg cctgtggtag    120

cagctactct gaaggctgag gtggtgcggc tgaacaagct ggaataatag aagctggaga    180

tgaaattctt gctattaatg ggaaacctct ggttgggctc atgcactttg atgcctggaa    240

tattatgaag tctgtcccag aaggacctgt gcagttatta attagaaagc ataggaattc    300

ttcatgaatt ttaacaagaa tcattttctc agttctcttc tttctttagc aaatcagagt    360

gacttcttta aaccacaggt tgttgaaatg gccaacactg gtacagacac ggactataaa    420

aatctccaag cttgtgctta cacatgaagc ctgacttaac tgtatgtgca acagcaatga    480

aattaactcc agaagccttc cacctgcgtc acccaggccg ggagggttcc ttcgttccag    540

tgcctgtccc ctacctttat gttatgttta ctgatgggga tacaagatgt gacacaccct    600

tctttatttg aaacaaacaa acatttagct ag                                  632


<210>  2647
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  2647

Met Ala Arg Pro His Leu Tyr Gln Lys Tyr Lys Lys Lys Ser Cys Ala 
1               5                   10                  15


Trp Trp Cys Met Pro Val Val Ala Ala Thr Leu Lys Ala Glu Val Val 
            20                  25                  30


Arg Leu Asn Lys Leu Glu 
        35


<210>  2648
<211>  3104
<212>  DNA
<213>  Homo sapiens

<400>  2648
atatatcagc cagaatctgt taacaattag aagctgacag cctgggcaac atggcaagac     60

cccatctcta ccaaaaatat aaaaaaaaaa gctgtgcatg gtggtgtatg cctgtggtag    120

cagctactct gaaggctgag gtggtgcggc tgaacaagct ggaataatag aagctggaga    180

tgaaattctt gctattaatg ggaaacctct ggttgggctc atgcactttg atgcctggaa    240

tattatgaag tctgtcccag aaggacctgt gcagttatta attagaaagc ataggaattc    300

ttcatgaatt ttaacaagaa tcattttctc agttctcttc tttctttagc aaatcagagt    360

gacttcttta aaccacaggt tgttgaaatg gccaacactg gtacagacac ggactataaa    420

aatctccaag cttgtgctta cacatgaagc ctgacttaac tgtatgtgca acagcaatga    480

aattaactcc agaagccttc cacctgcgtc acccaggccg ggagggttcc ttcgttccag    540

tgcctgtccc ctacctttat gttatgttta ctgatgggga tacaagatgt gacacaccct    600

tctttatttg aaacaaacaa acatttagct agacctttgc ttccttcttg ccagctctcc    660

caacataccc aatcctggtg atcagggaac taaaagtctg agggggacac aaatgtcaca    720

cctaagagga caatcaatca ttttgtatga ttttgtaagt aaatgacaga atgcttttag    780

gcacattcaa tggaaggagg agatgtaggt ctgtatatgt taccctgaaa agagaataag    840

acttacttaa aaaaatgaat tatgacctgt taggctgagc tcaggaattg tccaaaaagg    900

aaaaagcaaa ataattaatt gagagtattt tttagtgagt gtaatgtata atgtacgtat    960

gcaaagttca actcaatagg ttattgatca ccatgaagta ttgatcattt tctatctcaa   1020

aagtgtaagc cataaggctg ttttacagaa tagcacttct gataagctgt attaaatagc   1080

catgagcttc actgcttaga gggagcagaa aggtcaacat ctaaaagcac cttacaacta   1140

gtttttgaac ctgtcttgat aagtgcttga attcaagact ggtcagtcca agagcagaca   1200

aaaatatcac aagtcagtca gtcactgggt ttccatttct gaattttatg cactccaacc   1260

atgaatttaa actaaatttt tagaaatcaa gtatctttct aagtgtcctt ggatttatag   1320

acaatgtatg tacaatccaa atagaggagc ttaatggaat ccttttagga gactggttgg   1380

tttttttccc tctttcccaa catgtttaag aaatgtaaca ttctaagtat tggatctctt   1440

ttcttgacct agtataatga caactgcagt gacttaagtt tttgctgttt tcgttttccc   1500

gctttgcaat ttcctccttt tgccaaaaat gttttcctac agaagactgt cgtgactcac   1560

gctacttggg aaactcactc tggccactcc tcctctggtg gcatgagctg cttcccagta   1620

gctattccga ttggatattc cgttcgtcgt cacatagctg gcttttctct cctcatgatg   1680

taccttattt tcttaggtaa ataattccaa actctcatcg ggtcataaag aggaggagaa   1740

acagggtgag tcaaggtaaa ggagcagaaa tgtagttaca agccaggtcg tcttcagtgg   1800

cacaaaccaa cccgttgagc cctgacaaca tgagtggaga gtgcatttgc catacctgtg   1860

tgcatgacac taagatttta tgttggagat acttctttaa ataacctaca gcttgggtct   1920

atggctgtga cccccagatt catggagggg ctttagccat cagctttgta catcatcatt   1980

tttctgaatg accaatccca ctaaacatct ttgaagtcgg cctagagagg tccttcagat   2040

gagagagaaa tagctggctt gtctgagtcc agatttctca tcaactggca atacaaagga   2100

aaatatggta caggagttag ttagaaaggt cttattgatt ttacttctac ttttcactac   2160

agttacaggt agaatactgt aggaagtcag tgcaaggtgc atgcttgatt gatagatatt   2220

gattgattgt ttttcagtct ctggggtcag ttttgtggtt tctgctttct tgcctaaatc   2280

aaagactatt tcaagtcaac aacactgaaa actgcttttc gcctccactc ttacagctgt   2340

gcctaataat aattaattaa taaacgcaca gccctatgtg aacagacagg aatttcttgt   2400

gcaatgtgga gcaaatggaa tggtctcctt ccgcaagtct ttttaatcct catatctgga   2460

gtacaagggt agacctctgg cttaccacat acactatgct aaagtcatca gccactgcta   2520

ctacatcttg ccagaaggtt tccctcgcca acaaacagtt gaaatttaag ggaagaagca   2580

aaagctaaac tgtctttgac cctaagatag atagaaagct atttatttgt cttcagtgtt   2640

caaggcatga ctagtatttc taattagcct aataaattcc cacactttct gaagtgaaca   2700

ctaatggtat tgtcctacta aaactgtcat tgtttctttt tttttaactg gtcagtcatt   2760

cacaataagc tatgagggta aataaatatg tgttataaca agtaaaccgt agttgcaaga   2820

atataccatg aagattaaag taggctgggt ttcatttcca tcttcccaca catctcattg   2880

aatttgatgg ttgacttaat tggcaccata actttgtatg atattataca ttaaccttta   2940

tttatgtaaa gtaaaatgcc ttatatatta aagagtaagt gcaataatat gaaatagcct   3000

gtacatttta aaaatgttgt caccaagtta tataaatcca catctctgta aacaaccttt   3060

tttaagtaat tttaaaaaaa ataaacactc tgcttactac ttga                    3104


<210>  2649
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  2649

Met Ala Arg Pro His Leu Tyr Gln Lys Tyr Lys Lys Lys Ser Cys Ala 
1               5                   10                  15


Trp Trp Cys Met Pro Val Val Ala Ala Thr Leu Lys Ala Glu Val Val 
            20                  25                  30


Arg Leu Asn Lys Leu Glu 
        35


<210>  2650
<211>  2759
<212>  DNA
<213>  Homo sapiens

<400>  2650
aaaaaaaaaa aacaaaaaaa accgtaatgt taaattttat gacatttaaa tagctaacat     60

tataaaataa tacaatacaa tggatttaat tttgatatta tggaatttta actagaaact    120

tatagcttag ccaacaacgt gaatgaaggc tatagggttc taatacttgt ctacagcggt    180

gtaacatttt ccctcccatc tctccctctg gatttttcca cttttaaaat ggattctata    240

tctcaatgta gcccaagaaa cctttcttac ctctataatt tgttagcaag ttttaatgac    300

atttgtttaa aaatttgttt cttcactgat gtgaaatacc acctttataa tatatactga    360

attcttaaat ataatttagt cttatttctg ggactaataa taatgcttaa atgaatttct    420

ggatcacata gtccaaggtt cggtgatgag tcagtgagta taaactgtcc tagtatgttg    480

ctttactaat tattgcacag aattttcatt cattattata tctaatctgg ttaggttaaa    540

tattggattt ccttaacata aaagtaattt aaaatctgaa ctttgatact acatgaaagc    600

ttgaggcttt aagcataatg aattatttat ataattgttt gtttttcatt taatgagatc    660

aactcagaaa aggcattcgt ggatcctttc attctttttg ctttcttttt aggtaatctg    720

taagtcagat gctccaacag gggatgttct tcttgatgaa gctctgaagc atgttaagga    780

aactcagcct ccagaaacgg tccagaactg gattgaatta cttagtggtg agacatggaa    840

tccattaaaa ttgcattatc agttaagaaa tgtacgggaa cgattagcta aaaacctggt    900

ggaaaagggt gtattgacaa cagagaaaca gaacttccta ctttttgaca tgacaacaca    960

tcccctcacc aataacaaca ttaagcagcg cctcatcaag aaagtacagg aagccgttct   1020

tgacaaatgg gtgaatgacc ctcaccgcat ggacaggcgc ttgctggccc tcatttacct   1080

ggctcatgcc tcggacgtcc tggagaatgc ttttgctcct cttctggacg agcagtatga   1140

tttggctacc aagagagtgc ggcagcttct cgacttagac cctgaagtgg aatgtctgaa   1200

ggccaacacc aatgaggttc tgtgggcggt ggtggcggcg ttcaccaagt aactctgctc   1260

ggggtgaacc attctccttt ctctcaagta aaccagtagt ttttcttctg ttgacttctg   1320

gttttctgta atttgtactt tcccacacta taattggctt ctgttttaca aaatggtggg   1380

tggctttttc ttttttgtac gtgtacagga ttctgctggt acgagaggcc ttcctctttc   1440

tgtttttaaa aaaagtttta ctgccatatt ggcattccat tccctgttgc catcctcact   1500

gttacctgtt ttgggtttct ggtctacttt gactttcaaa gtacctccag cctcctcata   1560

cgcacagctt ttggatgacc tcagcttgag tttctccata tgtgcatgta catctagcat   1620

tctgcctaca gttcagacag aagtcacaaa aaggccttca actcaccaaa ggtaaatatc   1680

tgtatctatt aggacatttt ttacatagac ttcagttgag atgtatactt agcaaaatta   1740

tttttaaatt gaaacagcac agtaaatact taatataaaa tgtcccttgg attttgcttc   1800

ccatgtaaat ctattgtatt attacacttg ttataatttt aactataaag gtccaattgt   1860

ttcacagagc cagtttggga tgggctgcat tccatttatg ctgtatatag tttgaattat   1920

atataaatta ccccttcttc tggccacccc tgctcccatc ttagtatttt gcaagatcta   1980

atcagttgta cacctggtgc ccctcgcttg cttcaatcat ggttatttga tggcaaaatc   2040

gacctcttgt cgctgaagga gagagaaaag atgtgtgtct gattggtcct gggatttttt   2100

gagctgtgcc atttatggta ctctttgcct atgcatcccc ttgttagatt ttttttaaat   2160

tttatcttac tgtttttata atttctattg ggaagaggct tgtgaccagt accaatcttg   2220

agtttctttt tctgtccaca agtaaattaa tatctgctct gaaatgtcat ttatctactc   2280

acacattctt ggggaaaaaa atcaaatgtc agtcctagca gatgttgcat gtaaattggt   2340

agcaagtaat gattacaacc cagaggatta agaattttgt aacagaaagc tctatgtttt   2400

aattttttat atacaattag gataattagc attgtcagac tataaacctt tgctttttaa   2460

agtttatttt tactatttct ttatcacttt attgtatcat caccattggt ttcataatgt   2520

aaatactata tgttgaacaa attaaatgtc aaaatttttt attaccatag tccatgttaa   2580

tagtggggct ttcaggtgtt tagagatttt ttttgttgtt gttaacattc attgcaaaag   2640

tactagatgg tgtataactc tagagttgaa ttttaaggga ttccctaata tgtatactat   2700

ctttttatct gaagtaataa ataaacaatg atcttgaaag tgcctgaatc agagcaagc    2759


<210>  2651
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  2651

Met Asp Ser Ile Ser Gln Cys Ser Pro Arg Asn Leu Ser Tyr Leu Tyr 
1               5                   10                  15


Asn Leu Leu Ala Ser Phe Asn Asp Ile Cys Leu Lys Ile Cys Phe Phe 
            20                  25                  30


Thr Asp Val Lys Tyr His Leu Tyr Asn Ile Tyr 
        35                  40


<210>  2652
<211>  3189
<212>  DNA
<213>  Homo sapiens

<400>  2652
agcagagagc aaagtccttc ctgccgatcc tgcagacccc ggagtccaaa tgggaccccg     60

tccacacgac cgcggagtcg cctccgaaga cggcggtgtc tggggcgtgg agggcacggc    120

tggaggctga gtggggtcca ccttcgcgtg gcccaggctc ttccattcac ggggggcccc    180

gccaggttca ggctccagcc ctgggtagtg aaggggaaac ggggaacgga aggagggagg    240

gcacgtcacg ggagcaggac tgcaggaccg cgggtcaggg ggcgcaggaa cgccaaagaa    300

aagacaagca ccgagggccg ggaagggtgt aggctgcagt ggcagcggat ccccggccgc    360

cgcttccggc gcctcccggc ccagctctcc cgcgccgact ctgccacatc ctccggtgac    420

gtcagccggg gccgccatat tggaaaggcg ccgccgccgc ctccgccttg gagctcgggg    480

tgtttcgggg actgcggcca caggcaggaa ggcgctcctc tcctgccccg ccgacgcccg    540

gccagcccgc ttcgccctga cctgtttcct catgactgcc cccggccctg ctgccgacgg    600

acgtcgcccc ggcgtccgga tttaacacgg aaacccggat cggaggccgc gcggggagga    660

ggagggcgac ccggtcggtc ctgcgaccct ctcggcccgg ctcggcgcct cggcgggagc    720

catgacctcg ctgacccagc gcagctccgg cctggtgcag cggcgcaccg aggcctcccg    780

caacgccgcc gacaaggagc gggcggcggg cggcggcgcc ggcagcagcg aggacgacgc    840

gcagagccgc cgcgacgagc aggacgacga cgacaagggc gactccaagg aaacgcggct    900

gaccctgatg gaggaagtgc tcctgctggg cctcaaggac cgcgaggtgc gggcgcggcg    960

ggctgggcgg ggggcggcgg cgcggggccc gggcgccagg tgagctccag ggttacacat   1020

cattttggaa tgactgtata tcatctggat tacgtggctg tatgttaatt gaattagcat   1080

tgagaggaag gttacaacta gaggcttgtg gaatgagacg taaaagtcta ttaacaagaa   1140

aggtaatctg taagtcagat gctccaacag gggatgttct tcttgatgaa gctctgaagc   1200

atgttaagga aactcagcct ccagaaacgg tccagaactg gattgaatta cttagtggtg   1260

agacatggaa tccattaaaa ttgcattatc agttaagaaa tgtacgggaa cgattagcta   1320

aaaacctggt ggaaaagggt gtattgacaa cagagaaaca gaacttccta ctttttgaca   1380

tgacaacaca tcccctcacc aataacaaca ttaagcagcg cctcatcaag aaagtacagg   1440

aagccgttct tgacaaatgg gtgaatgacc ctcaccgcat ggacaggcgc ttgctggccc   1500

tcatttacct ggctcatgcc tcggacgtcc tggagaatgc ttttgctcct cttctggacg   1560

agcagtatga tttggctacc aagagagtgc ggcagcttct cgacttagac cctgaagtgg   1620

aatgtctgaa ggccaacacc aatgaggttc tgtgggcggt ggtggcggcg ttcaccaagt   1680

aactctgctc ggggtgaacc attctccttt ctctcaagta aaccagtagt ttttcttctg   1740

ttgacttctg gttttctgta atttgtactt tcccacacta taattggctt ctgttttaca   1800

aaatggtggg tggctttttc ttttttgtac gtgtacagga ttctgctggt acgagaggcc   1860

ttcctctttc tgtttttaaa aaaagtttta ctgccatatt ggcattccat tccctgttgc   1920

catcctcact gttacctgtt ttgggtttct ggtctacttt gactttcaaa gtacctccag   1980

cctcctcata cgcacagctt ttggatgacc tcagcttgag tttctccata tgtgcatgta   2040

catctagcat tctgcctaca gttcagacag aagtcacaaa aaggccttca actcaccaaa   2100

ggtaaatatc tgtatctatt aggacatttt ttacatagac ttcagttgag atgtatactt   2160

agcaaaatta tttttaaatt gaaacagcac agtaaatact taatataaaa tgtcccttgg   2220

attttgcttc ccatgtaaat ctattgtatt attacacttg ttataatttt aactataaag   2280

gtccaattgt ttcacagagc cagtttggga tgggctgcat tccatttatg ctgtatatag   2340

tttgaattat atataaatta ccccttcttc tggccacccc tgctcccatc ttagtatttt   2400

gcaagatcta atcagttgta cacctggtgc ccctcgcttg cttcaatcat ggttatttga   2460

tggcaaaatc gacctcttgt cgctgaagga gagagaaaag atgtgtgtct gattggtcct   2520

gggatttttt gagctgtgcc atttatggta ctctttgcct atgcatcccc ttgttagatt   2580

ttttttaaat tttatcttac tgtttttata atttctattg ggaagaggct tgtgaccagt   2640

accaatcttg agtttctttt tctgtccaca agtaaattaa tatctgctct gaaatgtcat   2700

ttatctactc acacattctt ggggaaaaaa atcaaatgtc agtcctagca gatgttgcat   2760

gtaaattggt agcaagtaat gattacaacc cagaggatta agaattttgt aacagaaagc   2820

tctatgtttt aattttttat atacaattag gataattagc attgtcagac tataaacctt   2880

tgctttttaa agtttatttt tactatttct ttatcacttt attgtatcat caccattggt   2940

ttcataatgt aaatactata tgttgaacaa attaaatgtc aaaatttttt attaccatag   3000

tccatgttaa tagtggggct ttcaggtgtt tagagatttt ttttgttgtt gttaacattc   3060

attgcaaaag tactagatgg tgtataactc tagagttgaa ttttaaggga ttccctaata   3120

tgtatactat ctttttatct gaagtaataa ataaacaatg atcttgaaag tgcctgaatc   3180

agagcaagc                                                           3189


<210>  2653
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  2653

Met Leu Ile Glu Leu Ala Leu Arg Gly Arg Leu Gln Leu Glu Ala Cys 
1               5                   10                  15


Gly Met Arg Arg Lys Ser Leu Leu Thr Arg Lys Val Ile Cys Lys Ser 
            20                  25                  30


Asp Ala Pro Thr Gly Asp Val Leu Leu Asp Glu Ala Leu Lys His Val 
        35                  40                  45


Lys Glu Thr Gln Pro Pro Glu Thr Val Gln Asn Trp Ile Glu Leu Leu 
    50                  55                  60


Ser Gly Glu Thr Trp Asn Pro Leu Lys Leu His Tyr Gln Leu Arg Asn 
65                  70                  75                  80


Val Arg Glu Arg Leu Ala Lys Asn Leu Val Glu Lys Gly Val Leu Thr 
                85                  90                  95


Thr Glu Lys Gln Asn Phe Leu Leu Phe Asp Met Thr Thr His Pro Leu 
            100                 105                 110


Thr Asn Asn Asn Ile Lys Gln Arg Leu Ile Lys Lys Val Gln Glu Ala 
        115                 120                 125


Val Leu Asp Lys Trp Val Asn Asp Pro His Arg Met Asp Arg Arg Leu 
    130                 135                 140


Leu Ala Leu Ile Tyr Leu Ala His Ala Ser Asp Val Leu Glu Asn Ala 
145                 150                 155                 160


Phe Ala Pro Leu Leu Asp Glu Gln Tyr Asp Leu Ala Thr Lys Arg Val 
                165                 170                 175


Arg Gln Leu Leu Asp Leu Asp Pro Glu Val Glu Cys Leu Lys Ala Asn 
            180                 185                 190


Thr Asn Glu Val Leu Trp Ala Val Val Ala Ala Phe Thr Lys 
        195                 200                 205


<210>  2654
<211>  2993
<212>  DNA
<213>  Homo sapiens

<400>  2654
agcagagagc aaagtccttc ctgccgatcc tgcagacccc ggagtccaaa tgggaccccg     60

tccacacgac cgcggagtcg cctccgaaga cggcggtgtc tggggcgtgg agggcacggc    120

tggaggctga gtggggtcca ccttcgcgtg gcccaggctc ttccattcac ggggggcccc    180

gccaggttca ggctccagcc ctgggtagtg aaggggaaac ggggaacgga aggagggagg    240

gcacgtcacg ggagcaggac tgcaggaccg cgggtcaggg ggcgcaggaa cgccaaagaa    300

aagacaagca ccgagggccg ggaagggtgt aggctgcagt ggcagcggat ccccggccgc    360

cgcttccggc gcctcccggc ccagctctcc cgcgccgact ctgccacatc ctccggtgac    420

gtcagccggg gccgccatat tggaaaggcg ccgccgccgc ctccgccttg gagctcgggg    480

tgtttcgggg actgcggcca caggcaggaa ggcgctcctc tcctgccccg ccgacgcccg    540

gccagcccgc ttcgccctga cctgtttcct catgactgcc cccggccctg ctgccgacgg    600

acgtcgcccc ggcgtccgga tttaacacgg aaacccggat cggaggccgc gcggggagga    660

ggagggcgac ccggtcggtc ctgcgaccct ctcggcccgg ctcggcgcct cggcgggagc    720

catgacctcg ctgacccagc gcagctccgg cctggtgcag cggcgcaccg aggcctcccg    780

caacgccgcc gacaaggagc gggcggcggg cggcggcgcc ggcagcagcg aggacgacgc    840

gcagagccgc cgcgacgagc aggacgacga cgacaagggc gactccaagg aaacgcggct    900

gaccctgatg gaggaagtgc tcctgctggg cctcaaggac cgcgaggtaa tctgtaagtc    960

agatgctcca acaggggatg ttcttcttga tgaagctctg aagcatgtta aggaaactca   1020

gcctccagaa acggtccaga actggattga attacttagt ggtgagacat ggaatccatt   1080

aaaattgcat tatcagttaa gaaatgtacg ggaacgatta gctaaaaacc tggtggaaaa   1140

gggtgtattg acaacagaga aacagaactt cctacttttt gacatgacaa cacatcccct   1200

caccaataac aacattaagc agcgcctcat caagaaagta caggaagccg ttcttgacaa   1260

atgggtgaat gaccctcacc gcatggacag gcgcttgctg gccctcattt acctggctca   1320

tgcctcggac gtcctggaga atgcttttgc tcctcttctg gacgagcagt atgatttggc   1380

taccaagaga gtgcggcagc ttctcgactt agaccctgaa gtggaatgtc tgaaggccaa   1440

caccaatgag gttctgtggg cggtggtggc ggcgttcacc aagtaactct gctcggggtg   1500

aaccattctc ctttctctca agtaaaccag tagtttttct tctgttgact tctggttttc   1560

tgtaatttgt actttcccac actataattg gcttctgttt tacaaaatgg tgggtggctt   1620

tttctttttt gtacgtgtac aggattctgc tggtacgaga ggccttcctc tttctgtttt   1680

taaaaaaagt tttactgcca tattggcatt ccattccctg ttgccatcct cactgttacc   1740

tgttttgggt ttctggtcta ctttgacttt caaagtacct ccagcctcct catacgcaca   1800

gcttttggat gacctcagct tgagtttctc catatgtgca tgtacatcta gcattctgcc   1860

tacagttcag acagaagtca caaaaaggcc ttcaactcac caaaggtaaa tatctgtatc   1920

tattaggaca ttttttacat agacttcagt tgagatgtat acttagcaaa attattttta   1980

aattgaaaca gcacagtaaa tacttaatat aaaatgtccc ttggattttg cttcccatgt   2040

aaatctattg tattattaca cttgttataa ttttaactat aaaggtccaa ttgtttcaca   2100

gagccagttt gggatgggct gcattccatt tatgctgtat atagtttgaa ttatatataa   2160

attacccctt cttctggcca cccctgctcc catcttagta ttttgcaaga tctaatcagt   2220

tgtacacctg gtgcccctcg cttgcttcaa tcatggttat ttgatggcaa aatcgacctc   2280

ttgtcgctga aggagagaga aaagatgtgt gtctgattgg tcctgggatt ttttgagctg   2340

tgccatttat ggtactcttt gcctatgcat ccccttgtta gatttttttt aaattttatc   2400

ttactgtttt tataatttct attgggaaga ggcttgtgac cagtaccaat cttgagtttc   2460

tttttctgtc cacaagtaaa ttaatatctg ctctgaaatg tcatttatct actcacacat   2520

tcttggggaa aaaaatcaaa tgtcagtcct agcagatgtt gcatgtaaat tggtagcaag   2580

taatgattac aacccagagg attaagaatt ttgtaacaga aagctctatg ttttaatttt   2640

ttatatacaa ttaggataat tagcattgtc agactataaa cctttgcttt ttaaagttta   2700

tttttactat ttctttatca ctttattgta tcatcaccat tggtttcata atgtaaatac   2760

tatatgttga acaaattaaa tgtcaaaatt ttttattacc atagtccatg ttaatagtgg   2820

ggctttcagg tgtttagaga ttttttttgt tgttgttaac attcattgca aaagtactag   2880

atggtgtata actctagagt tgaattttaa gggattccct aatatgtata ctatcttttt   2940

atctgaagta ataaataaac aatgatcttg aaagtgcctg aatcagagca agc          2993


<210>  2655
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  2655

Met Thr Ser Leu Thr Gln Arg Ser Ser Gly Leu Val Gln Arg Arg Thr 
1               5                   10                  15


Glu Ala Ser Arg Asn Ala Ala Asp Lys Glu Arg Ala Ala Gly Gly Gly 
            20                  25                  30


Ala Gly Ser Ser Glu Asp Asp Ala Gln Ser Arg Arg Asp Glu Gln Asp 
        35                  40                  45


Asp Asp Asp Lys Gly Asp Ser Lys Glu Thr Arg Leu Thr Leu Met Glu 
    50                  55                  60


Glu Val Leu Leu Leu Gly Leu Lys Asp Arg Glu Val Ile Cys Lys Ser 
65                  70                  75                  80


Asp Ala Pro Thr Gly Asp Val Leu Leu Asp Glu Ala Leu Lys His Val 
                85                  90                  95


Lys Glu Thr Gln Pro Pro Glu Thr Val Gln Asn Trp Ile Glu Leu Leu 
            100                 105                 110


Ser Gly Glu Thr Trp Asn Pro Leu Lys Leu His Tyr Gln Leu Arg Asn 
        115                 120                 125


Val Arg Glu Arg Leu Ala Lys Asn Leu Val Glu Lys Gly Val Leu Thr 
    130                 135                 140


Thr Glu Lys Gln Asn Phe Leu Leu Phe Asp Met Thr Thr His Pro Leu 
145                 150                 155                 160


Thr Asn Asn Asn Ile Lys Gln Arg Leu Ile Lys Lys Val Gln Glu Ala 
                165                 170                 175


Val Leu Asp Lys Trp Val Asn Asp Pro His Arg Met Asp Arg Arg Leu 
            180                 185                 190


Leu Ala Leu Ile Tyr Leu Ala His Ala Ser Asp Val Leu Glu Asn Ala 
        195                 200                 205


Phe Ala Pro Leu Leu Asp Glu Gln Tyr Asp Leu Ala Thr Lys Arg Val 
    210                 215                 220


Arg Gln Leu Leu Asp Leu Asp Pro Glu Val Glu Cys Leu Lys Ala Asn 
225                 230                 235                 240


Thr Asn Glu Val Leu Trp Ala Val Val Ala Ala Phe Thr Lys 
                245                 250


<210>  2656
<211>  3027
<212>  DNA
<213>  Homo sapiens

<400>  2656
agcagagagc aaagtccttc ctgccgatcc tgcagacccc ggagtccaaa tgggaccccg     60

tccacacgac cgcggagtcg cctccgaaga cggcggtgtc tggggcgtgg agggcacggc    120

tggaggctga gtggggtcca ccttcgcgtg gcccaggctc ttccattcac ggggggcccc    180

gccaggttca ggctccagcc ctgggtagtg aaggggaaac ggggaacgga aggagggagg    240

gcacgtcacg ggagcaggac tgcaggaccg cgggtcaggg ggcgcaggaa cgccaaagaa    300

aagacaagca ccgagggccg ggaagggtgt aggctgcagt ggcagcggat ccccggccgc    360

cgcttccggc gcctcccggc ccagctctcc cgcgccgact ctgccacatc ctccggtgac    420

gtcagccggg gccgccatat tggaaaggcg ccgccgccgc ctccgccttg gagctcgggg    480

tgtttcgggg actgcggcca caggcaggaa ggcgctcctc tcctgccccg ccgacgcccg    540

gccagcccgc ttcgccctga cctgtttcct catgactgcc cccggccctg ctgccgacgg    600

acgtcgcccc ggcgtccgga tttaacacgg aaacccggat cggaggccgc gcggggagga    660

ggagggcgac ccggtcggtc ctgcgaccct ctcggcccgg ctcggcgcct cggcgggagc    720

catgacctcg ctgacccagc gcagagagcc gccgcgacga gcaggacgac gacgacaagg    780

gcgactccaa ggaaacgcgg ctgaccctga tggaggaagt gctcctgctg ggcctcaagg    840

accgcgaggg ttacacatca ttttggaatg actgtatatc atctggatta cgtggctgta    900

tgttaattga attagcattg agaggaaggt tacaactaga ggcttgtgga atgagacgta    960

aaagtctatt aacaagaaag gtaatctgta agtcagatgc tccaacaggg gatgttcttc   1020

ttgatgaagc tctgaagcat gttaaggaaa ctcagcctcc agaaacggtc cagaactgga   1080

ttgaattact tagtggtgag acatggaatc cattaaaatt gcattatcag ttaagaaatg   1140

tacgggaacg attagctaaa aacctggtgg aaaagggtgt attgacaaca gagaaacaga   1200

acttcctact ttttgacatg acaacacatc ccctcaccaa taacaacatt aagcagcgcc   1260

tcatcaagaa agtacaggaa gccgttcttg acaaatgggt gaatgaccct caccgcatgg   1320

acaggcgctt gctggccctc atttacctgg ctcatgcctc ggacgtcctg gagaatgctt   1380

ttgctcctct tctggacgag cagtatgatt tggctaccaa gagagtgcgg cagcttctcg   1440

acttagaccc tgaagtggaa tgtctgaagg ccaacaccaa tgaggttctg tgggcggtgg   1500

tggcggcgtt caccaagtaa ctctgctcgg ggtgaaccat tctcctttct ctcaagtaaa   1560

ccagtagttt ttcttctgtt gacttctggt tttctgtaat ttgtactttc ccacactata   1620

attggcttct gttttacaaa atggtgggtg gctttttctt ttttgtacgt gtacaggatt   1680

ctgctggtac gagaggcctt cctctttctg tttttaaaaa aagttttact gccatattgg   1740

cattccattc cctgttgcca tcctcactgt tacctgtttt gggtttctgg tctactttga   1800

ctttcaaagt acctccagcc tcctcatacg cacagctttt ggatgacctc agcttgagtt   1860

tctccatatg tgcatgtaca tctagcattc tgcctacagt tcagacagaa gtcacaaaaa   1920

ggccttcaac tcaccaaagg taaatatctg tatctattag gacatttttt acatagactt   1980

cagttgagat gtatacttag caaaattatt tttaaattga aacagcacag taaatactta   2040

atataaaatg tcccttggat tttgcttccc atgtaaatct attgtattat tacacttgtt   2100

ataattttaa ctataaaggt ccaattgttt cacagagcca gtttgggatg ggctgcattc   2160

catttatgct gtatatagtt tgaattatat ataaattacc ccttcttctg gccacccctg   2220

ctcccatctt agtattttgc aagatctaat cagttgtaca cctggtgccc ctcgcttgct   2280

tcaatcatgg ttatttgatg gcaaaatcga cctcttgtcg ctgaaggaga gagaaaagat   2340

gtgtgtctga ttggtcctgg gattttttga gctgtgccat ttatggtact ctttgcctat   2400

gcatcccctt gttagatttt ttttaaattt tatcttactg tttttataat ttctattggg   2460

aagaggcttg tgaccagtac caatcttgag tttctttttc tgtccacaag taaattaata   2520

tctgctctga aatgtcattt atctactcac acattcttgg ggaaaaaaat caaatgtcag   2580

tcctagcaga tgttgcatgt aaattggtag caagtaatga ttacaaccca gaggattaag   2640

aattttgtaa cagaaagctc tatgttttaa ttttttatat acaattagga taattagcat   2700

tgtcagacta taaacctttg ctttttaaag tttattttta ctatttcttt atcactttat   2760

tgtatcatca ccattggttt cataatgtaa atactatatg ttgaacaaat taaatgtcaa   2820

aattttttat taccatagtc catgttaata gtggggcttt caggtgttta gagatttttt   2880

ttgttgttgt taacattcat tgcaaaagta ctagatggtg tataactcta gagttgaatt   2940

ttaagggatt ccctaatatg tatactatct ttttatctga agtaataaat aaacaatgat   3000

cttgaaagtg cctgaatcag agcaagc                                       3027


<210>  2657
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  2657

Met Glu Glu Val Leu Leu Leu Gly Leu Lys Asp Arg Glu Gly Tyr Thr 
1               5                   10                  15


Ser Phe Trp Asn Asp Cys Ile Ser Ser Gly Leu Arg Gly Cys Met Leu 
            20                  25                  30


Ile Glu Leu Ala Leu Arg Gly Arg Leu Gln Leu Glu Ala Cys Gly Met 
        35                  40                  45


Arg Arg Lys Ser Leu Leu Thr Arg Lys Val Ile Cys Lys Ser Asp Ala 
    50                  55                  60


Pro Thr Gly Asp Val Leu Leu Asp Glu Ala Leu Lys His Val Lys Glu 
65                  70                  75                  80


Thr Gln Pro Pro Glu Thr Val Gln Asn Trp Ile Glu Leu Leu Ser Gly 
                85                  90                  95


Glu Thr Trp Asn Pro Leu Lys Leu His Tyr Gln Leu Arg Asn Val Arg 
            100                 105                 110


Glu Arg Leu Ala Lys Asn Leu Val Glu Lys Gly Val Leu Thr Thr Glu 
        115                 120                 125


Lys Gln Asn Phe Leu Leu Phe Asp Met Thr Thr His Pro Leu Thr Asn 
    130                 135                 140


Asn Asn Ile Lys Gln Arg Leu Ile Lys Lys Val Gln Glu Ala Val Leu 
145                 150                 155                 160


Asp Lys Trp Val Asn Asp Pro His Arg Met Asp Arg Arg Leu Leu Ala 
                165                 170                 175


Leu Ile Tyr Leu Ala His Ala Ser Asp Val Leu Glu Asn Ala Phe Ala 
            180                 185                 190


Pro Leu Leu Asp Glu Gln Tyr Asp Leu Ala Thr Lys Arg Val Arg Gln 
        195                 200                 205


Leu Leu Asp Leu Asp Pro Glu Val Glu Cys Leu Lys Ala Asn Thr Asn 
    210                 215                 220


Glu Val Leu Trp Ala Val Val Ala Ala Phe Thr Lys 
225                 230                 235


<210>  2658
<211>  2731
<212>  DNA
<213>  Homo sapiens

<400>  2658
agcagagagc aaagtccttc ctgccgatcc tgcagacccc ggagtccaaa tgggaccccg     60

tccacacgac cgcggagtcg cctccgaaga cggcggtgtc tggggcgtgg agggcacggc    120

tggaggctga gtggggtcca ccttcgcgtg gcccaggctc ttccattcac ggggggcccc    180

gccaggttca ggctccagcc ctgggtagtg aaggggaaac ggggaacgga aggagggagg    240

gcacgtcacg ggagcaggac tgcaggaccg cgggtcaggg ggcgcaggaa cgccaaagaa    300

aagacaagca ccgagggccg ggaagggtgt aggctgcagt ggcagcggat ccccggccgc    360

cgcttccggc gcctcccggc ccagctctcc cgcgccgact ctgccacatc ctccggtgac    420

gtcagccggg gccgccatat tggaaaggcg ccgccgccgc ctccgccttg gagctcgggg    480

tgtttcgggg actgcggcca caggcaggaa ggcgctcctc tcctgccccg ccgacgcccg    540

gccagcccgc ttcgccctga cctgtttcct catgactgta tatcatctgg attacgtggc    600

tgtatgttaa ttgaattagc attgagagga aggttacaac tagaggcttg tggaatgaga    660

cgtaaaagtc tattaacaag aaaggtaatc tgtaagtcag atgctccaac aggggatgtt    720

cttcttgatg aagctctgaa gcatgttaag gaaactcagc ctccagaaac ggtccagaac    780

tggattgaat tacttagtgg tgagacatgg aatccattaa aattgcatta tcagttaaga    840

aatgtacggg aacgattagc taaaaacctg gtggaaaagg gtgtattgac aacagagaaa    900

cagaacttcc tactttttga catgacaaca catcccctca ccaataacaa cattaagcag    960

cgcctcatca agaaagtaca ggaagccgtt cttgacaaat gggtgaatga ccctcaccgc   1020

atggacaggc gcttgctggc cctcatttac ctggctcatg cctcggacgt cctggagaat   1080

gcttttgctc ctcttctgga cgagcagtat gatttggcta ccaagagagt gcggcagctt   1140

ctcgacttag accctgaagt ggaatgtctg aaggccaaca ccaatgaggt tctgtgggcg   1200

gtggtggcgg cgttcaccaa gtaactctgc tcggggtgaa ccattctcct ttctctcaag   1260

taaaccagta gtttttcttc tgttgacttc tggttttctg taatttgtac tttcccacac   1320

tataattggc ttctgtttta caaaatggtg ggtggctttt tcttttttgt acgtgtacag   1380

gattctgctg gtacgagagg ccttcctctt tctgttttta aaaaaagttt tactgccata   1440

ttggcattcc attccctgtt gccatcctca ctgttacctg ttttgggttt ctggtctact   1500

ttgactttca aagtacctcc agcctcctca tacgcacagc ttttggatga cctcagcttg   1560

agtttctcca tatgtgcatg tacatctagc attctgccta cagttcagac agaagtcaca   1620

aaaaggcctt caactcacca aaggtaaata tctgtatcta ttaggacatt ttttacatag   1680

acttcagttg agatgtatac ttagcaaaat tatttttaaa ttgaaacagc acagtaaata   1740

cttaatataa aatgtccctt ggattttgct tcccatgtaa atctattgta ttattacact   1800

tgttataatt ttaactataa aggtccaatt gtttcacaga gccagtttgg gatgggctgc   1860

attccattta tgctgtatat agtttgaatt atatataaat taccccttct tctggccacc   1920

cctgctccca tcttagtatt ttgcaagatc taatcagttg tacacctggt gcccctcgct   1980

tgcttcaatc atggttattt gatggcaaaa tcgacctctt gtcgctgaag gagagagaaa   2040

agatgtgtgt ctgattggtc ctgggatttt ttgagctgtg ccatttatgg tactctttgc   2100

ctatgcatcc ccttgttaga ttttttttaa attttatctt actgttttta taatttctat   2160

tgggaagagg cttgtgacca gtaccaatct tgagtttctt tttctgtcca caagtaaatt   2220

aatatctgct ctgaaatgtc atttatctac tcacacattc ttggggaaaa aaatcaaatg   2280

tcagtcctag cagatgttgc atgtaaattg gtagcaagta atgattacaa cccagaggat   2340

taagaatttt gtaacagaaa gctctatgtt ttaatttttt atatacaatt aggataatta   2400

gcattgtcag actataaacc tttgcttttt aaagtttatt tttactattt ctttatcact   2460

ttattgtatc atcaccattg gtttcataat gtaaatacta tatgttgaac aaattaaatg   2520

tcaaaatttt ttattaccat agtccatgtt aatagtgggg ctttcaggtg tttagagatt   2580

ttttttgttg ttgttaacat tcattgcaaa agtactagat ggtgtataac tctagagttg   2640

aattttaagg gattccctaa tatgtatact atctttttat ctgaagtaat aaataaacaa   2700

tgatcttgaa agtgcctgaa tcagagcaag c                                  2731


<210>  2659
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  2659

Met Leu Ile Glu Leu Ala Leu Arg Gly Arg Leu Gln Leu Glu Ala Cys 
1               5                   10                  15


Gly Met Arg Arg Lys Ser Leu Leu Thr Arg Lys Val Ile Cys Lys Ser 
            20                  25                  30


Asp Ala Pro Thr Gly Asp Val Leu Leu Asp Glu Ala Leu Lys His Val 
        35                  40                  45


Lys Glu Thr Gln Pro Pro Glu Thr Val Gln Asn Trp Ile Glu Leu Leu 
    50                  55                  60


Ser Gly Glu Thr Trp Asn Pro Leu Lys Leu His Tyr Gln Leu Arg Asn 
65                  70                  75                  80


Val Arg Glu Arg Leu Ala Lys Asn Leu Val Glu Lys Gly Val Leu Thr 
                85                  90                  95


Thr Glu Lys Gln Asn Phe Leu Leu Phe Asp Met Thr Thr His Pro Leu 
            100                 105                 110


Thr Asn Asn Asn Ile Lys Gln Arg Leu Ile Lys Lys Val Gln Glu Ala 
        115                 120                 125


Val Leu Asp Lys Trp Val Asn Asp Pro His Arg Met Asp Arg Arg Leu 
    130                 135                 140


Leu Ala Leu Ile Tyr Leu Ala His Ala Ser Asp Val Leu Glu Asn Ala 
145                 150                 155                 160


Phe Ala Pro Leu Leu Asp Glu Gln Tyr Asp Leu Ala Thr Lys Arg Val 
                165                 170                 175


Arg Gln Leu Leu Asp Leu Asp Pro Glu Val Glu Cys Leu Lys Ala Asn 
            180                 185                 190


Thr Asn Glu Val Leu Trp Ala Val Val Ala Ala Phe Thr Lys 
        195                 200                 205


<210>  2660
<211>  3125
<212>  DNA
<213>  Homo sapiens

<400>  2660
agcagagagc aaagtccttc ctgccgatcc tgcagacccc ggagtccaaa tgggaccccg     60

tccacacgac cgcggagtcg cctccgaaga cggcggtgtc tggggcgtgg agggcacggc    120

tggaggctga gtggggtcca ccttcgcgtg gcccaggctc ttccattcac ggggggcccc    180

gccaggttca ggctccagcc ctgggtagtg aaggggaaac ggggaacgga aggagggagg    240

gcacgtcacg ggagcaggac tgcaggaccg cgggtcaggg ggcgcaggaa cgccaaagaa    300

aagacaagca ccgagggccg ggaagggtgt aggctgcagt ggcagcggat ccccggccgc    360

cgcttccggc gcctcccggc ccagctctcc cgcgccgact ctgccacatc ctccggtgac    420

gtcagccggg gccgccatat tggaaaggcg ccgccgccgc ctccgccttg gagctcgggg    480

tgtttcgggg actgcggcca caggcaggaa ggcgctcctc tcctgccccg ccgacgcccg    540

gccagcccgc ttcgccctga cctgtttcct catgactgcc cccggccctg ctgccgacgg    600

acgtcgcccc ggcgtccgga tttaacacgg aaacccggat cggaggccgc gcggggagga    660

ggagggcgac ccggtcggtc ctgcgaccct ctcggcccgg ctcggcgcct cggcgggagc    720

catgacctcg ctgacccagc gcagctccgg cctggtgcag cggcgcaccg aggcctcccg    780

caacgccgcc gacaaggagc gggcggcggg cggcggcgcc ggcagcagcg aggacgacgc    840

gcagagccgc cgcgacgagc aggacgacga cgacaagggc gactccaagg aaacgcggct    900

gaccctgatg gaggaagtgc tcctgctggg cctcaaggac cgcgagggtt acacatcatt    960

ttggaatgac tgtatatcat ctggattacg tggctgtatg ttaattgaat tagcattgag   1020

aggaaggtta caactagagg cttgtggaat gagacgtaaa agtctattaa caagaaaggt   1080

aatctgtaag tcagatgctc caacagggga tgttcttctt gatgaagctc tgaagcatgt   1140

taaggaaact cagcctccag aaacggtcca gaactggatt gaattactta gtggtgagac   1200

atggaatcca ttaaaattgc attatcagtt aagaaatgta cgggaacgat tagctaaaaa   1260

cctggtggaa aagggtgtat tgacaacaga gaaacagaac ttcctacttt ttgacatgac   1320

aacacatccc ctcaccaata acaacattaa gcagcgcctc atcaagaaag tacaggaagc   1380

cgttcttgac aaatgggtga atgaccctca ccgcatggac aggcgcttgc tggccctcat   1440

ttacctggct catgcctcgg acgtcctgga gaatgctttt gctcctcttc tggacgagca   1500

gtatgatttg gctaccaaga gagtgcggca gcttctcgac ttagaccctg aagtggaatg   1560

tctgaaggcc aacaccaatg aggttctgtg ggcggtggtg gcggcgttca ccaagtaact   1620

ctgctcgggg tgaaccattc tcctttctct caagtaaacc agtagttttt cttctgttga   1680

cttctggttt tctgtaattt gtactttccc acactataat tggcttctgt tttacaaaat   1740

ggtgggtggc tttttctttt ttgtacgtgt acaggattct gctggtacga gaggccttcc   1800

tctttctgtt tttaaaaaaa gttttactgc catattggca ttccattccc tgttgccatc   1860

ctcactgtta cctgttttgg gtttctggtc tactttgact ttcaaagtac ctccagcctc   1920

ctcatacgca cagcttttgg atgacctcag cttgagtttc tccatatgtg catgtacatc   1980

tagcattctg cctacagttc agacagaagt cacaaaaagg ccttcaactc accaaaggta   2040

aatatctgta tctattagga cattttttac atagacttca gttgagatgt atacttagca   2100

aaattatttt taaattgaaa cagcacagta aatacttaat ataaaatgtc ccttggattt   2160

tgcttcccat gtaaatctat tgtattatta cacttgttat aattttaact ataaaggtcc   2220

aattgtttca cagagccagt ttgggatggg ctgcattcca tttatgctgt atatagtttg   2280

aattatatat aaattacccc ttcttctggc cacccctgct cccatcttag tattttgcaa   2340

gatctaatca gttgtacacc tggtgcccct cgcttgcttc aatcatggtt atttgatggc   2400

aaaatcgacc tcttgtcgct gaaggagaga gaaaagatgt gtgtctgatt ggtcctggga   2460

ttttttgagc tgtgccattt atggtactct ttgcctatgc atccccttgt tagatttttt   2520

ttaaatttta tcttactgtt tttataattt ctattgggaa gaggcttgtg accagtacca   2580

atcttgagtt tctttttctg tccacaagta aattaatatc tgctctgaaa tgtcatttat   2640

ctactcacac attcttgggg aaaaaaatca aatgtcagtc ctagcagatg ttgcatgtaa   2700

attggtagca agtaatgatt acaacccaga ggattaagaa ttttgtaaca gaaagctcta   2760

tgttttaatt ttttatatac aattaggata attagcattg tcagactata aacctttgct   2820

ttttaaagtt tatttttact atttctttat cactttattg tatcatcacc attggtttca   2880

taatgtaaat actatatgtt gaacaaatta aatgtcaaaa ttttttatta ccatagtcca   2940

tgttaatagt ggggctttca ggtgtttaga gatttttttt gttgttgtta acattcattg   3000

caaaagtact agatggtgta taactctaga gttgaatttt aagggattcc ctaatatgta   3060

tactatcttt ttatctgaag taataaataa acaatgatct tgaaagtgcc tgaatcagag   3120

caagc                                                               3125


<210>  2661
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  2661

Met Thr Ser Leu Thr Gln Arg Ser Ser Gly Leu Val Gln Arg Arg Thr 
1               5                   10                  15


Glu Ala Ser Arg Asn Ala Ala Asp Lys Glu Arg Ala Ala Gly Gly Gly 
            20                  25                  30


Ala Gly Ser Ser Glu Asp Asp Ala Gln Ser Arg Arg Asp Glu Gln Asp 
        35                  40                  45


Asp Asp Asp Lys Gly Asp Ser Lys Glu Thr Arg Leu Thr Leu Met Glu 
    50                  55                  60


Glu Val Leu Leu Leu Gly Leu Lys Asp Arg Glu Gly Tyr Thr Ser Phe 
65                  70                  75                  80


Trp Asn Asp Cys Ile Ser Ser Gly Leu Arg Gly Cys Met Leu Ile Glu 
                85                  90                  95


Leu Ala Leu Arg Gly Arg Leu Gln Leu Glu Ala Cys Gly Met Arg Arg 
            100                 105                 110


Lys Ser Leu Leu Thr Arg Lys Val Ile Cys Lys Ser Asp Ala Pro Thr 
        115                 120                 125


Gly Asp Val Leu Leu Asp Glu Ala Leu Lys His Val Lys Glu Thr Gln 
    130                 135                 140


Pro Pro Glu Thr Val Gln Asn Trp Ile Glu Leu Leu Ser Gly Glu Thr 
145                 150                 155                 160


Trp Asn Pro Leu Lys Leu His Tyr Gln Leu Arg Asn Val Arg Glu Arg 
                165                 170                 175


Leu Ala Lys Asn Leu Val Glu Lys Gly Val Leu Thr Thr Glu Lys Gln 
            180                 185                 190


Asn Phe Leu Leu Phe Asp Met Thr Thr His Pro Leu Thr Asn Asn Asn 
        195                 200                 205


Ile Lys Gln Arg Leu Ile Lys Lys Val Gln Glu Ala Val Leu Asp Lys 
    210                 215                 220


Trp Val Asn Asp Pro His Arg Met Asp Arg Arg Leu Leu Ala Leu Ile 
225                 230                 235                 240


Tyr Leu Ala His Ala Ser Asp Val Leu Glu Asn Ala Phe Ala Pro Leu 
                245                 250                 255


Leu Asp Glu Gln Tyr Asp Leu Ala Thr Lys Arg Val Arg Gln Leu Leu 
            260                 265                 270


Asp Leu Asp Pro Glu Val Glu Cys Leu Lys Ala Asn Thr Asn Glu Val 
        275                 280                 285


Leu Trp Ala Val Val Ala Ala Phe Thr Lys 
    290                 295


<210>  2662
<211>  1292
<212>  DNA
<213>  Homo sapiens

<400>  2662
gaacgattag ctaaaaacct ggtggaaaag ggtgtattga caacagagaa acagaacttc     60

ctactttttg acatgacaac acatcccctc accaataaca acattaagca gcgcctcatc    120

aagaaagtac aggaagccgt tcttgacaaa tgggtgaatg accctcaccg catggacagg    180

cgcttgctgg ccctcattta cctggctcat gcctcggacg tcctggagaa tgcttttgct    240

cctcttctgg acgagcagta tgatttggct accaagagag tgcggcagct tctcgactta    300

gaccctgaag tggaatgtct gaaggccaac accaatgagg ttctgtgggc ggtggtggcg    360

gcgttcacca agtaactctg ctcggggtga accattctcc tttctctcaa gtaaaccagt    420

agtttttctt ctgttgactt ctggttttct gtaatttgta ctttcccaca ctataattgg    480

cttctgtttt acaaaatggt gggtggcttt ttcttttttg tacgtgtaca ggattctgct    540

ggtacgagag gccttcctct ttctgttttt aaaaaaagtt ttactgccat attggcattc    600

cattccctgt tgccatcctc actgttacct gttttgggtt tctggtctac tttgactttc    660

aaagtacctc cagcctcctc atacgcacag cttttggatg acctcagctt gagtttctcc    720

atatgtgcat gtacatctag cattctgcct acagttcaga cagaagtcac aaaaaggcct    780

tcaactcacc aaaggtaaat atctgtatct attaggacat tttttacata gacttcagtt    840

gagatgtata cttagcaaaa ttatttttaa attgaaacag cacagtaaat acttaatata    900

aaatgtccct tggattttgc ttcccatgta aatctattgt attattacac ttgttataat    960

tttaactata aaggtccaat tgtttcacag agccagtttg ggatgggctg cattccattt   1020

atgctgtata tagtttgaat tatatataaa ttaccccttc ttctggccac ccctgctccc   1080

atcttagtat tttgcaagat ctaatcagtt gtacacctgg tgcccctcgc ttgtggggct   1140

ttcaggtgtt tagagatttt ttttgttgtt gttaacattc attgcaaaag tactagatgg   1200

tgtataactc tagagttgaa ttttaaggga ttccctaata tgtatactat ctttttatct   1260

gaagtaataa ataaacaatg atcttgaaag tg                                 1292


<210>  2663
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  2663

Met Val Gly Gly Phe Phe Phe Phe Val Arg Val Gln Asp Ser Ala Gly 
1               5                   10                  15


Thr Arg Gly Leu Pro Leu Ser Val Phe Lys Lys Ser Phe Thr Ala Ile 
            20                  25                  30


Leu Ala Phe His Ser Leu Leu Pro Ser Ser Leu Leu Pro Val Leu Gly 
        35                  40                  45


Phe Trp Ser Thr Leu Thr Phe Lys Val Pro Pro Ala Ser Ser Tyr Ala 
    50                  55                  60


Gln Leu Leu Asp Asp Leu Ser Leu Ser Phe Ser Ile Cys Ala Cys Thr 
65                  70                  75                  80


Ser Ser Ile Leu Pro Thr Val Gln Thr Glu Val Thr Lys Arg Pro Ser 
                85                  90                  95


Thr His Gln Arg 
            100


<210>  2664
<211>  487
<212>  DNA
<213>  Homo sapiens

<400>  2664
aaaaaaaaaa aacaaaaaaa accgtaatgt taaattttat gacatttaaa tagctaacat     60

tataaaataa tacaatacaa tggatttaat tttgatatta tggaatttta actagaaact    120

tatagcttag ccaacaacgt gaatgaaggc tatagggttc taatacttgt ctacagcggt    180

gtaacatttt ccctcccatc tctccctctg gatttttcca cttttaaaat ggattctata    240

tctcaatgta gctttctgtt tggaaacaga tttttgctct tgtcgcccag gctggagtgc    300

aaaggtgcga tctcagctca ctgcagcctc cacctcctgg gttcaagcaa ttctcctgcc    360

tcagcctccc aagtagctgg gtttacaggc atgcgccacc acacctggct aatttttgta    420

ttattagtag agaccgggtt tcaccatcct gaccaacatg gagaaacccc atctttacta    480

aaaatac                                                              487


<210>  2665
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  2665

Met Asp Ser Ile Ser Gln Cys Ser Phe Leu Phe Gly Asn Arg Phe Leu 
1               5                   10                  15


Leu Leu Ser Pro Arg Leu Glu Cys Lys Gly Ala Ile Ser Ala His Cys 
            20                  25                  30


Ser Leu His Leu Leu Gly Ser Ser Asn Ser Pro Ala Ser Ala Ser Gln 
        35                  40                  45


Val Ala Gly Phe Thr Gly Met Arg His His Thr Trp Leu Ile Phe Val 
    50                  55                  60


Leu Leu Val Glu Thr Gly Phe His His Pro Asp Gln His Gly Glu Thr 
65                  70                  75                  80


Pro Ser Leu Leu Lys 
                85


<210>  2666
<211>  624
<212>  DNA
<213>  Homo sapiens

<400>  2666
ggttctcatc ttgctaaatg acatttagaa gcagcataac tgcttctaat ctaggattac     60

cacacatcta ggattctaac agttttcatc cattcatcaa atgtttactg agcacatgct    120

ctgtgagagg ccctttacta agtacaaatt cactgaagaa catgtctgtc ttcaagttca    180

ttcattttag ttctgtgtgt caaagctcat atagtaaact acaaaactaa attatgttgc    240

tgttctagaa tttttttttt ttctcttctg agacagagtc ttgctctgtt acccaggctg    300

gagtgcagtg gtgcaatcta tgctcacttc aacctctgcc tcctgggttc aagcgattct    360

cctgcctcaa ccttctgagt agctgggatt acaggcactc accaccacac aggggtactt    420

tttgtatttt tagtagagac aaggtttcgc catgttggcc aggctggtct caaactcatg    480

acctcatgtg atccacccac cactttggga ggctgaggca aggggattac ctgaggcagg    540

gagttagcga ccagcctggc caacatggtg aaactccatc tctactaaaa atacaaaaat    600

tagccaggca gggtggtatg cacc                                           624


<210>  2667
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  2667

Arg Thr Cys Leu Ser Ser Ser Ser Phe Ile Leu Val Leu Cys Val Lys 
1               5                   10                  15


Ala His Ile Val Asn Tyr Lys Thr Lys Leu Cys Cys Cys Ser Arg Ile 
            20                  25                  30


Phe Phe Phe Ser Leu Leu Arg Gln Ser Leu Ala Leu Leu Pro Arg Leu 
        35                  40                  45


Glu Cys Ser Gly Ala Ile Tyr Ala His Phe Asn Leu Cys Leu Leu Gly 
    50                  55                  60


Ser Ser Asp Ser Pro Ala Ser Thr Phe 
65                  70


<210>  2668
<211>  5004
<212>  DNA
<213>  Homo sapiens

<400>  2668
ggagccggat gcgggcggca tcgcggcggt cgcggccttg gggatgggcg gagccccagc     60

cgctagtgct ggtggccgcc gctgctgccc cagctggagc ccgagccgcc gcctctgcgt    120

ccgcgcgtcg ctgcttccca gggcggcggt atgctgggga aaggagtagt cggcggtggc    180

ggcggcacca aggcccccaa gccctccttc gtgtcgtacg tacgccctga ggaaattcac    240

acaaacgaaa aggaagtaac agagaaggaa gtaactcttc acttgttgcc aggtgaacag    300

ctgctttgtg aagccagcac agtactgaag tatgtccagg aagattcctg tcagcatggg    360

gtctatggga ggcttgtctg cacagacttc aagattgcct tcttgggtga tgatgaatct    420

gcattggata atgatgaaac tcaatttaag aataaggtta taggagaaaa tgacattaca    480

ctccactgtg ttgatcagat ttatggagtg tttgatgaga aaaagaaaac tctctttgga    540

caactgaaga aataccctga gaagctcatc atccactgca aagaccttcg agtgttccag    600

ttttgtctga ggtacacaaa ggaagaggaa gtcaaaagga ttgtcagtgg cataattcat    660

catacccagg ctcctaaact gcttaaacga ttatttctgt tttcctatgc gactgctgca    720

caaaacaata cagtcactga tcccaagaac cataccgtaa tgtttgacac acttaaggac    780

tggtgttggg aactggaacg gaccaaaggc aacatgaagt acaaagcagt gagtgtcaac    840

gaaggctata aagtctgtga gagattgcca gcatactttg ttgtccccac ccctcttcct    900

gaagagaatg tgcagcgctt tcagggtcat ggcataccaa tatggtgttg gtcctgccac    960

aatggaagtg cccttttgaa aatgtcagca ctgcccaaag aacaggatga cggcatttta   1020

caaatccaaa agagcttctt agatggaatt tacaagacca tccacaggcc accctatgaa   1080

attgttaaaa cggaagacct gtcaagcaac ttcctgtccc tgcaggaaat ccagactgca   1140

tactctaaat ttaaacagct atttctgata gataacagta ctgaattttg ggacacagat   1200

ataaaatggt tttctctgtt ggaaagtagc agctggcttg acataatcag acgttgcctg   1260

aaaaaagcaa tagagattac agaatgtatg gaagcacaaa acatgaatgt tcttctttta   1320

gaggagaatg catccgacct ctgctgtctc atttcctctc tggtgcaact gatgatggac   1380

ccccactgca gaaccagaat tggtttccag agcctcatcc aaaaggagtg ggtcatgggt   1440

ggccactgtt tcttggatcg ctgcaaccat ctccgccaga acgacaaaga ggaggttcct   1500

gtgttcctgc ttttcctaga ttgtgtctgg cagctggtgc accagcatcc cccggcattt   1560

gaattcacag agacttacct gactgttttg tcagatagcc tgtatatacc tatttttagc   1620

accttcttct tcaattcacc tcatcaaaaa gatactaaca tgcatcaacg acaactttct   1680

ttgccactta cacaatctaa gtcatctccc aaaagaggat ttttcaggga agaaacagat   1740

catttaatta aaaaccttct gggcaagaga attagcaaac ttattaattc ttctgatgag   1800

ctccaagaca actttcgaga gttctatgac agctggcata gcaagtccac tgactaccat   1860

ggtttgttgt taccgcatat cgaggggccc gaaatcaaag tctgggccca gcgctaccta   1920

cgttggattc cagaagccca aatcctaggt ggtggccaag tggccactct gagcaaactc   1980

ttggaaatga tggaggaagt ccagagttta caagagaaga tcgacgagag acaccacagc   2040

cagcaggccc cccaggctga ggccccctgc ctgctgagga actctgcccg cctctcgtct   2100

ttgtttcctt tcgctctgct ccagcgacat tcctctaagc ccgtcttacc caccagtggc   2160

tggaaagctt tgggagatga agacgatttg gccaaacgag aagatgagtt cgtggaccta   2220

ggggatgtgt gacctgtttg ttgagtgatt gtgaaagagg aatgtgggag attgggacag   2280

ctgatccctg gatttgtgtc acgctacagc tcatgctggc tgggtcctta gcccggcact   2340

ccgttagaat aaacctgggc cttcgggaaa agaggtggct ctcattattt ttcatgattc   2400

taaaagacta tgcaattaaa accgcatctg tagtattact aattggaagg aattattact   2460

tgacccgtaa tagggttgtg gccgttttct gatgcctaag tattatacag agcccacaat   2520

ggccagttta ctaccagaaa gggcttcagt aagatattct tggacttgat actttcttca   2580

gatcctcttt gtgccaagat aatttatcca gtcattggga atagtaagtt tctgtgtaac   2640

ccatctcaat tatagaagca agttcagctt tatgtatttg tatggggagt tgaagattca   2700

gatagaggta ttaagatgtg tggcatttac ttaaaccatc acattttttt ctttctacgc   2760

ccccttgcct gtaaaacacc tgggaagttc cactggtgtc atccatcctg atgcttcaga   2820

ccaccctccc ttcttcacag accgtgtcac tttgcctgtg ggtgggggct agccagccac   2880

caccctcttt tctgtgctgc cagccccagg tcttcctccg cctgctccac accactcgcc   2940

gctgtccctc tgcactccct gccttggtgc gtgtagtccc agtgtctcac tgccaaacct   3000

cttggttacg ctgcggggat ctgtttcttt gcctgagatc cttcctgagg agcgtccatt   3060

cctctggagt ctctccttgt ttggaacaaa tcgcttcgcc tttttctact tgcctgctga   3120

agctttggag cacttgtgat tgcagttttc tgccgcaacc cctgagccga gttcctcaca   3180

ttcttttacc tttatggact gatgggattg ggtcactttt gaatgtggct ttcataggaa   3240

agcagcttaa acataaatat cagaagtgat gattatcata tgatacctca gtgattttaa   3300

aagccataga agaaacttga ctatgcctgg tcaccttctt ggatctgctg tctaaatgat   3360

atatatatga tatatatgtg atatatatat atcatatata tgatatatat atatatatca   3420

catatatatg atatatatat gatatatata tatcacatat atatgatata tatatcatat   3480

atatgatata tatttttttt aatgcaggaa agtatacttt gtaaggagca gatttttttg   3540

ttctcagtgg aaccctgtca aatcgcataa aagaggaaaa aaacaaaact cattagaatg   3600

ttttaaattg aatgttcgcc ttttacatat atttgctctt cagtatggat cccaatttga   3660

atgttacatg ttcggaaaaa ctttcagttg ctcaagggca ataagaaaat ttgaggccgg   3720

gtgtggtggc tcacgcctgt aatcccagca ctttgggagg ctcaggtggg cgaattgctt   3780

gagcccagga gttcgagacc agccggggca acatggcaaa accctgtctc tactaaaaat   3840

acaaaaatta gctgggtgtg gtggtgcatg cctgtagtcc cagctactcg ggaggctgag   3900

gtgggaggat cccgtgagcc tgggaggtgg agtttgcagt gagctaagat cgtgccactg   3960

cactccggcc tgggtgatgg agcaagacct cgtctcagaa aattggaaac tattgactaa   4020

gagaagtttc taggtttgca ctgaattgtc ttttgtacat acagtgaatt gttttgctgt   4080

tctccccact ccatattaat gcaggagcca ggttggtctg ttaggatgaa caaaggttga   4140

ggggagggca ggattcgtgc atctgggggc caaacacatg ttccgtcttg attgccttaa   4200

gagttactag cgaggtcagt gttaggcttg caatagggat tttaaaatac actaactagt   4260

tccttagcta ccttcacata cattctatag gccttcttaa attagcacta acctccactt   4320

ccttctctgc cccattgcct cccaaatatg ctatggagct atttttgtta ccacgttata   4380

acgtgaatat ttatacagta gcctcttcag gctttgtaat tttcattcca aaaatgcccg   4440

gtgtgatgct ttacactcta caaagtatgg tttaaaggca caaggtcatg gcctttgtca   4500

tagcagttga atgtgcattg acatattttt ctatgatttt ttaaaattac aatagaaaaa   4560

taagctgttg taacgtgtaa ggtcatgaca atttttgtat ttatatttga aatcagattt   4620

ctataactcg tatttgtgta cagaattctc aatggattta tatattgtga aatttttatc   4680

tgagattggg atgtggatta tgcttaacag tgagagctga aatgagacca tttactttgt   4740

ttaaaatgct gtactgtgca agtttggaaa tgtaaattaa tttactgtat ataatatctt   4800

gagtttgttt atacctccaa gtttttacac tgaagataaa ctagctttaa ttcaaaactt   4860

tttttttctt tataagggaa taagctgttg agctaaacct gtatacttgt gctttttatt   4920

ttctggatgc acaatgaaag tttatacttg tatctcactg catcatatct gattgcagaa   4980

attaaagcac aatttacaag caat                                          5004


<210>  2669
<211>  693
<212>  PRT
<213>  Homo sapiens

<400>  2669

Met Leu Gly Lys Gly Val Val Gly Gly Gly Gly Gly Thr Lys Ala Pro 
1               5                   10                  15


Lys Pro Ser Phe Val Ser Tyr Val Arg Pro Glu Glu Ile His Thr Asn 
            20                  25                  30


Glu Lys Glu Val Thr Glu Lys Glu Val Thr Leu His Leu Leu Pro Gly 
        35                  40                  45


Glu Gln Leu Leu Cys Glu Ala Ser Thr Val Leu Lys Tyr Val Gln Glu 
    50                  55                  60


Asp Ser Cys Gln His Gly Val Tyr Gly Arg Leu Val Cys Thr Asp Phe 
65                  70                  75                  80


Lys Ile Ala Phe Leu Gly Asp Asp Glu Ser Ala Leu Asp Asn Asp Glu 
                85                  90                  95


Thr Gln Phe Lys Asn Lys Val Ile Gly Glu Asn Asp Ile Thr Leu His 
            100                 105                 110


Cys Val Asp Gln Ile Tyr Gly Val Phe Asp Glu Lys Lys Lys Thr Leu 
        115                 120                 125


Phe Gly Gln Leu Lys Lys Tyr Pro Glu Lys Leu Ile Ile His Cys Lys 
    130                 135                 140


Asp Leu Arg Val Phe Gln Phe Cys Leu Arg Tyr Thr Lys Glu Glu Glu 
145                 150                 155                 160


Val Lys Arg Ile Val Ser Gly Ile Ile His His Thr Gln Ala Pro Lys 
                165                 170                 175


Leu Leu Lys Arg Leu Phe Leu Phe Ser Tyr Ala Thr Ala Ala Gln Asn 
            180                 185                 190


Asn Thr Val Thr Asp Pro Lys Asn His Thr Val Met Phe Asp Thr Leu 
        195                 200                 205


Lys Asp Trp Cys Trp Glu Leu Glu Arg Thr Lys Gly Asn Met Lys Tyr 
    210                 215                 220


Lys Ala Val Ser Val Asn Glu Gly Tyr Lys Val Cys Glu Arg Leu Pro 
225                 230                 235                 240


Ala Tyr Phe Val Val Pro Thr Pro Leu Pro Glu Glu Asn Val Gln Arg 
                245                 250                 255


Phe Gln Gly His Gly Ile Pro Ile Trp Cys Trp Ser Cys His Asn Gly 
            260                 265                 270


Ser Ala Leu Leu Lys Met Ser Ala Leu Pro Lys Glu Gln Asp Asp Gly 
        275                 280                 285


Ile Leu Gln Ile Gln Lys Ser Phe Leu Asp Gly Ile Tyr Lys Thr Ile 
    290                 295                 300


His Arg Pro Pro Tyr Glu Ile Val Lys Thr Glu Asp Leu Ser Ser Asn 
305                 310                 315                 320


Phe Leu Ser Leu Gln Glu Ile Gln Thr Ala Tyr Ser Lys Phe Lys Gln 
                325                 330                 335


Leu Phe Leu Ile Asp Asn Ser Thr Glu Phe Trp Asp Thr Asp Ile Lys 
            340                 345                 350


Trp Phe Ser Leu Leu Glu Ser Ser Ser Trp Leu Asp Ile Ile Arg Arg 
        355                 360                 365


Cys Leu Lys Lys Ala Ile Glu Ile Thr Glu Cys Met Glu Ala Gln Asn 
    370                 375                 380


Met Asn Val Leu Leu Leu Glu Glu Asn Ala Ser Asp Leu Cys Cys Leu 
385                 390                 395                 400


Ile Ser Ser Leu Val Gln Leu Met Met Asp Pro His Cys Arg Thr Arg 
                405                 410                 415


Ile Gly Phe Gln Ser Leu Ile Gln Lys Glu Trp Val Met Gly Gly His 
            420                 425                 430


Cys Phe Leu Asp Arg Cys Asn His Leu Arg Gln Asn Asp Lys Glu Glu 
        435                 440                 445


Val Pro Val Phe Leu Leu Phe Leu Asp Cys Val Trp Gln Leu Val His 
    450                 455                 460


Gln His Pro Pro Ala Phe Glu Phe Thr Glu Thr Tyr Leu Thr Val Leu 
465                 470                 475                 480


Ser Asp Ser Leu Tyr Ile Pro Ile Phe Ser Thr Phe Phe Phe Asn Ser 
                485                 490                 495


Pro His Gln Lys Asp Thr Asn Met His Gln Arg Gln Leu Ser Leu Pro 
            500                 505                 510


Leu Thr Gln Ser Lys Ser Ser Pro Lys Arg Gly Phe Phe Arg Glu Glu 
        515                 520                 525


Thr Asp His Leu Ile Lys Asn Leu Leu Gly Lys Arg Ile Ser Lys Leu 
    530                 535                 540


Ile Asn Ser Ser Asp Glu Leu Gln Asp Asn Phe Arg Glu Phe Tyr Asp 
545                 550                 555                 560


Ser Trp His Ser Lys Ser Thr Asp Tyr His Gly Leu Leu Leu Pro His 
                565                 570                 575


Ile Glu Gly Pro Glu Ile Lys Val Trp Ala Gln Arg Tyr Leu Arg Trp 
            580                 585                 590


Ile Pro Glu Ala Gln Ile Leu Gly Gly Gly Gln Val Ala Thr Leu Ser 
        595                 600                 605


Lys Leu Leu Glu Met Met Glu Glu Val Gln Ser Leu Gln Glu Lys Ile 
    610                 615                 620


Asp Glu Arg His His Ser Gln Gln Ala Pro Gln Ala Glu Ala Pro Cys 
625                 630                 635                 640


Leu Leu Arg Asn Ser Ala Arg Leu Ser Ser Leu Phe Pro Phe Ala Leu 
                645                 650                 655


Leu Gln Arg His Ser Ser Lys Pro Val Leu Pro Thr Ser Gly Trp Lys 
            660                 665                 670


Ala Leu Gly Asp Glu Asp Asp Leu Ala Lys Arg Glu Asp Glu Phe Val 
        675                 680                 685


Asp Leu Gly Asp Val 
    690


<210>  2670
<211>  4740
<212>  DNA
<213>  Homo sapiens

<400>  2670
ggagccggat gcgggcggca tcgcggcggt cgcggccttg gggatgggcg gagccccagc     60

cgctagtgct ggtggccgcc gctgctgccc cagctggagc ccgagccgcc gcctctgcgt    120

ccgcgcgtcg ctgcttccca gggcggcggt atgctgggga aaggagtagt cggcggtggc    180

ggcggcacca aggcccccaa gccctccttc gtgtcgtacg tacgccctga ggaaattcac    240

acaaacgaaa aggaagtaac agagaaggaa gtaactcttc acttgttgcc aggtgaacag    300

ctgctttgtg aagccagcac agtactgaag tatgtccagg aagattcctg tcagcatggg    360

gtctatggga ggcttgtctg cacagacttc aagattgcct tcttgggtga tgatgaatct    420

gcattggata atgatgaaac tcaatttaag aataaggtta taggagaaaa tgacattaca    480

ctccactgtg ttgatcagat ttatggagtg tttgatgaga aaaagaaaac tctctttgga    540

caactgaaga aataccctga gaagctcatc atccactgca aagaccttcg agtgttccag    600

ttttgtctga ggtacacaaa ggaagaggaa gtcaaaagga ttgtcagtgg cataattcat    660

catacccagg ctcctaaact gcttaaacga ttatttctgt tttcctatgc gactgctgca    720

caaaacaata cagtcactga tcccaagaac cataccgtaa tgtttgacac acttaaggac    780

tggtgttggg aactggaacg gaccaaaggc aacatgaagt acaaagcagt gagtgtcaac    840

gaaggctata aagtctgtga gagattgcca gcatactttg ttgtccccac ccctcttcct    900

gaagagaatg tgcagcgctt tcagggtcat ggcataccaa tatggtgttg gtcctgccac    960

aatggaagtg cccttttgaa aatgtcagca ctgcccaaag aacaggatga cggcatttta   1020

caaatccaaa agagcttctt agatggaatt tacaagacca tccacaggcc accctatgaa   1080

attgttaaaa cggaagacct gtcaagcaac ttcctgtccc tgcaggaaat ccagactgca   1140

tactctaaat ttaaacagct atttctgata gataacagta ctgaattttg ggacacagat   1200

ataaaatggt tttctctgtt ggaaagtagc agctggcttg acataatcag acgttgcctg   1260

aaaaaagcaa tagagattac agaatgtatg gaagcacaaa acatgaatgt tcttctttta   1320

gaggagaatg catccgacct ctgctgtctc atttcctctc tggtgcaact gatgatggac   1380

ccccactgca gaaccagaat tggtttccag agcctcatcc aaaaggagtg ggtcatgggt   1440

ggccactgtt tcttggatcg ctgcaaccat ctccgccaga acgacaaaga ggaggttcct   1500

gtgttcctgc ttttcctaga ttgtgtctgg cagctggtgc accagcatcc cccggcattt   1560

gaattcacag agacttacct gactgttttg tcagatagcc tgtatatacc tatttttagc   1620

accttcttct tcaattcacc tcatcaaaaa gatactaaca tgggtagaga aggccaggat   1680

acacaaagca agcctttgaa tctgctcacc gtgtgggatt ggtcggtgca gtttgaaccc   1740

aaagcccaga cattgctcaa aaaccctctt tatgtggaaa agccaaaact ggacaaaggc   1800

caacggaaag gaatgcgctt caaacatcaa cgacaacttt ctttgccact tacacaatct   1860

aagtcatctc ccaaaagagg atttttcagg gaagaaacag atcatttaat taaaaacctt   1920

ctgggcaaga gaattagcaa acttattaat tcttctgatg agctccaaga caactttcga   1980

gagttctatg acagctggca tagcaagtcc actgactacc atggtttgtt gttaccgcat   2040

atcgaggggc ccgaaatcaa agtctgggcc cagcgctacc tacgttggat tccagaagcc   2100

caaatcctag gtggtggcca agtggccact ctgagcaaac tcttggaaat gatggaggaa   2160

gtccagagtt tacaagagaa gatcgacgag agacaccaca gccagcaggc cccccaggct   2220

gaggccccct gcctgctgag gaactctgcc cgcctctcgt ctttgtttcc tttcgctctg   2280

ctccagcgac attcctctaa gcccgtctta cccaccagtg gctggaaagc tttgggagat   2340

gaagacgatt tggccaaacg agaagatgag ttcgtggacc taggggatgt gtgacctgtt   2400

tgttgagtga ttgtgaaaga ggaatgtggg agattgggac agctgatccc tggatttgtg   2460

tcacgctaca gctcatgctg gctgggtcct tagcccggca ctccgttaga ataaacctgg   2520

gccttcggga aaagaggtgg ctctcattat ttttcatgat tctaaaagac tatgcaatta   2580

aaaccgcatc tgtagtatta ctaattggaa ggaattatta cttgacccgt aatagggttg   2640

tggccgtttt ctgatgccta agtattatac agagcccaca atggccagtt tactaccaga   2700

aagggcttca gtaagatatt cttggacttg atactttctt cagatcctct ttgtgccaag   2760

ataatttatc cagtcattgg gaatagtaag tttctgtgta acccatctca attatagaag   2820

caagttcagc tttatgtatt tgtatgggga gttgaagatt cagatagagg tattaagatg   2880

tgtggcattt acttaaacca tcacattttt ttctttctac gcccccttgc ctgtaaaaca   2940

cctgggaagt tccactggtg tcatccatcc tgatgcttca gaccaccctc ccttcttcac   3000

agaccgtgtc actttgcctg tgggtggggg ctagccagcc accaccctct tttctgtgct   3060

gccagcccca ggtcttcctc cgcctgctcc acaccactcg ccgctgtccc tctgcactcc   3120

ctgccttggt gcgtgtagtc ccagtgtctc actgccaaac ctcttggtta cgctgcgggg   3180

atctgtttct ttgcctgaga tccttcctga ggagcgtcca ttcctctgga gtctctcctt   3240

gtttggaaca aatcgcttcg cctttttcta cttgcctgct gaagctttgg agcacttgtg   3300

attgcagttt tctgccgcaa cccctgagcc gagttcctca cattctttta cctttatgga   3360

ctgatgggat tgggtcactt ttgaatgtgg ctttcatagg aaagcagctt aaacataaat   3420

atcagaagtg atgattatca tatgatacct cagtgatttt aaaagccata gaagaaactt   3480

gactatgcct ggtcaccttc ttggatctgc tgtctaattt ttttaatgca ggaaagtata   3540

ctttgtaagg agcagatttt tttgttctca gtggaaccct gtcaaatcgc ataaaagagg   3600

aaaaaaacaa aactcattag aatgttttaa attgaatgtt cgccttttac atatatttgc   3660

tcttcagtat ggatcccaat ttgaatgtta catgttcgga aaaactttca gttgctcaag   3720

ggcaataaga aaatttgatt ggaaactatt gactaagaga agtttctagg tttgcactga   3780

attgtctttt gtacatacag tgaattgttt tgctgttctc cccactccat attaatgcag   3840

gagccaggtt ggtctgttag gatgaacaaa ggttgagggg agggcaggat tcgtgcatct   3900

gggggccaaa cacatgttcc gtcttgattg ccttaagagt tactagcgag gtcagtgtta   3960

ggcttgcaat agggatttta aaatacacta actagttcct tagctacctt cacatacatt   4020

ctataggcct tcttaaatta gcactaacct ccacttcctt ctctgcccca ttgcctccca   4080

aatatgctat ggagctattt ttgttaccac gttataacgt gaatatttat acagtagcct   4140

cttcaggctt tgtaattttc attccaaaaa tgcccggtgt gatgctttac actctacaaa   4200

gtatggttta aaggcacaag gtcatggcct ttgtcatagc agttgaatgt gcattgacat   4260

atttttctat gattttttaa aattacaata gaaaaataag ctgttgtaac gtgtaaggtc   4320

atgacaattt ttgtatttat atttgaaatc agatttctat aactcgtatt tgtgtacaga   4380

attctcaatg gatttatata ttgtgaaatt tttatctgag attgggatgt ggattatgct   4440

taacagtgag agctgaaatg agaccattta ctttgtttaa aatgctgtac tgtgcaagtt   4500

tggaaatgta aattaattta ctgtatataa tatcttgagt ttgtttatac ctccaagttt   4560

ttacactgaa gataaactag ctttaattca aaactttttt tttctttata agggaataag   4620

ctgttgagct aaacctgtat acttgtgctt tttattttct ggatgcacaa tgaaagttta   4680

tacttgtatc tcactgcatc atatctgatt gcagaaatta aagcacaatt tacaagcaat   4740


<210>  2671
<211>  747
<212>  PRT
<213>  Homo sapiens

<400>  2671

Met Leu Gly Lys Gly Val Val Gly Gly Gly Gly Gly Thr Lys Ala Pro 
1               5                   10                  15


Lys Pro Ser Phe Val Ser Tyr Val Arg Pro Glu Glu Ile His Thr Asn 
            20                  25                  30


Glu Lys Glu Val Thr Glu Lys Glu Val Thr Leu His Leu Leu Pro Gly 
        35                  40                  45


Glu Gln Leu Leu Cys Glu Ala Ser Thr Val Leu Lys Tyr Val Gln Glu 
    50                  55                  60


Asp Ser Cys Gln His Gly Val Tyr Gly Arg Leu Val Cys Thr Asp Phe 
65                  70                  75                  80


Lys Ile Ala Phe Leu Gly Asp Asp Glu Ser Ala Leu Asp Asn Asp Glu 
                85                  90                  95


Thr Gln Phe Lys Asn Lys Val Ile Gly Glu Asn Asp Ile Thr Leu His 
            100                 105                 110


Cys Val Asp Gln Ile Tyr Gly Val Phe Asp Glu Lys Lys Lys Thr Leu 
        115                 120                 125


Phe Gly Gln Leu Lys Lys Tyr Pro Glu Lys Leu Ile Ile His Cys Lys 
    130                 135                 140


Asp Leu Arg Val Phe Gln Phe Cys Leu Arg Tyr Thr Lys Glu Glu Glu 
145                 150                 155                 160


Val Lys Arg Ile Val Ser Gly Ile Ile His His Thr Gln Ala Pro Lys 
                165                 170                 175


Leu Leu Lys Arg Leu Phe Leu Phe Ser Tyr Ala Thr Ala Ala Gln Asn 
            180                 185                 190


Asn Thr Val Thr Asp Pro Lys Asn His Thr Val Met Phe Asp Thr Leu 
        195                 200                 205


Lys Asp Trp Cys Trp Glu Leu Glu Arg Thr Lys Gly Asn Met Lys Tyr 
    210                 215                 220


Lys Ala Val Ser Val Asn Glu Gly Tyr Lys Val Cys Glu Arg Leu Pro 
225                 230                 235                 240


Ala Tyr Phe Val Val Pro Thr Pro Leu Pro Glu Glu Asn Val Gln Arg 
                245                 250                 255


Phe Gln Gly His Gly Ile Pro Ile Trp Cys Trp Ser Cys His Asn Gly 
            260                 265                 270


Ser Ala Leu Leu Lys Met Ser Ala Leu Pro Lys Glu Gln Asp Asp Gly 
        275                 280                 285


Ile Leu Gln Ile Gln Lys Ser Phe Leu Asp Gly Ile Tyr Lys Thr Ile 
    290                 295                 300


His Arg Pro Pro Tyr Glu Ile Val Lys Thr Glu Asp Leu Ser Ser Asn 
305                 310                 315                 320


Phe Leu Ser Leu Gln Glu Ile Gln Thr Ala Tyr Ser Lys Phe Lys Gln 
                325                 330                 335


Leu Phe Leu Ile Asp Asn Ser Thr Glu Phe Trp Asp Thr Asp Ile Lys 
            340                 345                 350


Trp Phe Ser Leu Leu Glu Ser Ser Ser Trp Leu Asp Ile Ile Arg Arg 
        355                 360                 365


Cys Leu Lys Lys Ala Ile Glu Ile Thr Glu Cys Met Glu Ala Gln Asn 
    370                 375                 380


Met Asn Val Leu Leu Leu Glu Glu Asn Ala Ser Asp Leu Cys Cys Leu 
385                 390                 395                 400


Ile Ser Ser Leu Val Gln Leu Met Met Asp Pro His Cys Arg Thr Arg 
                405                 410                 415


Ile Gly Phe Gln Ser Leu Ile Gln Lys Glu Trp Val Met Gly Gly His 
            420                 425                 430


Cys Phe Leu Asp Arg Cys Asn His Leu Arg Gln Asn Asp Lys Glu Glu 
        435                 440                 445


Val Pro Val Phe Leu Leu Phe Leu Asp Cys Val Trp Gln Leu Val His 
    450                 455                 460


Gln His Pro Pro Ala Phe Glu Phe Thr Glu Thr Tyr Leu Thr Val Leu 
465                 470                 475                 480


Ser Asp Ser Leu Tyr Ile Pro Ile Phe Ser Thr Phe Phe Phe Asn Ser 
                485                 490                 495


Pro His Gln Lys Asp Thr Asn Met Gly Arg Glu Gly Gln Asp Thr Gln 
            500                 505                 510


Ser Lys Pro Leu Asn Leu Leu Thr Val Trp Asp Trp Ser Val Gln Phe 
        515                 520                 525


Glu Pro Lys Ala Gln Thr Leu Leu Lys Asn Pro Leu Tyr Val Glu Lys 
    530                 535                 540


Pro Lys Leu Asp Lys Gly Gln Arg Lys Gly Met Arg Phe Lys His Gln 
545                 550                 555                 560


Arg Gln Leu Ser Leu Pro Leu Thr Gln Ser Lys Ser Ser Pro Lys Arg 
                565                 570                 575


Gly Phe Phe Arg Glu Glu Thr Asp His Leu Ile Lys Asn Leu Leu Gly 
            580                 585                 590


Lys Arg Ile Ser Lys Leu Ile Asn Ser Ser Asp Glu Leu Gln Asp Asn 
        595                 600                 605


Phe Arg Glu Phe Tyr Asp Ser Trp His Ser Lys Ser Thr Asp Tyr His 
    610                 615                 620


Gly Leu Leu Leu Pro His Ile Glu Gly Pro Glu Ile Lys Val Trp Ala 
625                 630                 635                 640


Gln Arg Tyr Leu Arg Trp Ile Pro Glu Ala Gln Ile Leu Gly Gly Gly 
                645                 650                 655


Gln Val Ala Thr Leu Ser Lys Leu Leu Glu Met Met Glu Glu Val Gln 
            660                 665                 670


Ser Leu Gln Glu Lys Ile Asp Glu Arg His His Ser Gln Gln Ala Pro 
        675                 680                 685


Gln Ala Glu Ala Pro Cys Leu Leu Arg Asn Ser Ala Arg Leu Ser Ser 
    690                 695                 700


Leu Phe Pro Phe Ala Leu Leu Gln Arg His Ser Ser Lys Pro Val Leu 
705                 710                 715                 720


Pro Thr Ser Gly Trp Lys Ala Leu Gly Asp Glu Asp Asp Leu Ala Lys 
                725                 730                 735


Arg Glu Asp Glu Phe Val Asp Leu Gly Asp Val 
            740                 745


<210>  2672
<211>  2199
<212>  DNA
<213>  Homo sapiens

<400>  2672
ggagccggat gcgggcggca tcgcggcggt cgcggccttg gggatgggcg gagccccagc     60

cgctagtgct ggtggccgcc gctgctgccc cagctggagc ccgagccgcc gcctctgcgt    120

ccgcgcgtcg ctgcttccca gggcggcggt atgctgggga aaggagtagt cggcggtggc    180

ggcggcacca aggcccccaa gccctccttc gtgtcgtacg tacgccctga ggaaattcac    240

acaaacgaaa aggaagtaac agagaaggaa gtaactcttc acttgttgcc aggtgaacag    300

ctgctttgtg aagccagcac agtactgaag tatgtccagg aagattcctg tcagcatggg    360

gtctatggga ggcttgtctg cacagacttc aagattgcct tcttgggtga tgatgaatct    420

gcattggata atgatgaaac tcaatttaag aataaggtta taggagaaaa tgacattaca    480

ctccactgtg ttgatcagat ttatggagtg tttgatgaga aaaagaaaac tctctttgga    540

caactgaaga aataccctga gaagctcatc atccactgca aagaccttcg agtgttccag    600

ttttgtctga ggtacacaaa ggaagaggaa gtcaaaagga ttgtcagtgg cataattcat    660

catacccagg ctcctaaact gcttaaacga ttatttctgt tttcctatgc gactgctgca    720

caaaacaata cagtcactga tcccaagaac cataccgtaa tgtttgacac acttaaggac    780

tggtgttggg aactggaacg gaccaaaggc aacatgaagt acaaagcagt gagtgtcaac    840

gaaggctata aagtctgtga gagattgcca gcatactttg ttgtccccac ccctcttcct    900

gaagagaatg tgcagcgctt tcagggtcat ggcataccaa tatggtgttg gtcctgccac    960

aatggaagtg cccttttgaa aatgtcagca ctgcccaaag aacaggatga cggcatttta   1020

caaatccaaa agagcttctt agatggaatt tacaagacca tccacaggcc accctatgaa   1080

attgttaaaa cggaagacct gtcaagcaac ttcctgtccc tgcaggaaat ccagactgca   1140

tactctaaat ttaaacagct atttctgata gataacagta ctgaattttg ggacacagat   1200

ataaaatggt tttctctgtt ggaaagtagc agctggcttg acataatcag acgttgcctg   1260

aaaaaagcaa tagagattac agaatgtatg gaagcacaaa acatgaatgt tcttctttta   1320

gaggagaatg catccgacct ctgctgtctc atttcctctc tggtgcaact gatgatggac   1380

ccccactgca gaaccagaat tggtttccag agcctcatcc aaaaggagtg ggtcatgggt   1440

ggccactgtt tcttggatcg ctgcaaccat ctccgccaga acgacaaaga ggagcatcaa   1500

cgacaacttt ctttgccact tacacaatct aagtcatctc ccaaaagagg atttttcagg   1560

gaagaaacag atcatttaat taaaaacctt ctgggcaaga gaattagcaa acttattaat   1620

tcttctgatg agctccaaga caactttcga gagttctatg acagctggca tagcaagtcc   1680

actgactacc atggtttgtt gttaccgcat atcgaggggc ccgaaatcaa agtctgggcc   1740

cagcgctacc tacgttggat tccagaagcc caaatcctag gtggtggcca agtggccact   1800

ctgagcaaac tcttggaaat gatggaggaa gtccagagtt tacaagagaa gatcgacgag   1860

agacaccaca gccagcaggc cccccaggct gaggccccct gcctgctgag gaactctgcc   1920

cgcctctcgt ctttgtttcc tttcgctctg ctccagcgac attcctctaa gcccgtctta   1980

cccaccagtg gctggaaagc tttgggagat gaagacgatt tggccaaacg agaagatgag   2040

ttcgtggacc taggggatgt gtgacctgtt tgttgagtga ttgtgaaaga ggaatgtggg   2100

agattgggac agctgatccc tggatttgtg tcacgctaca gctcatgctg gctgggtcct   2160

tagcccggca ctccgttaga ataaacctgg gccttcggg                          2199


<210>  2673
<211>  637
<212>  PRT
<213>  Homo sapiens

<400>  2673

Met Leu Gly Lys Gly Val Val Gly Gly Gly Gly Gly Thr Lys Ala Pro 
1               5                   10                  15


Lys Pro Ser Phe Val Ser Tyr Val Arg Pro Glu Glu Ile His Thr Asn 
            20                  25                  30


Glu Lys Glu Val Thr Glu Lys Glu Val Thr Leu His Leu Leu Pro Gly 
        35                  40                  45


Glu Gln Leu Leu Cys Glu Ala Ser Thr Val Leu Lys Tyr Val Gln Glu 
    50                  55                  60


Asp Ser Cys Gln His Gly Val Tyr Gly Arg Leu Val Cys Thr Asp Phe 
65                  70                  75                  80


Lys Ile Ala Phe Leu Gly Asp Asp Glu Ser Ala Leu Asp Asn Asp Glu 
                85                  90                  95


Thr Gln Phe Lys Asn Lys Val Ile Gly Glu Asn Asp Ile Thr Leu His 
            100                 105                 110


Cys Val Asp Gln Ile Tyr Gly Val Phe Asp Glu Lys Lys Lys Thr Leu 
        115                 120                 125


Phe Gly Gln Leu Lys Lys Tyr Pro Glu Lys Leu Ile Ile His Cys Lys 
    130                 135                 140


Asp Leu Arg Val Phe Gln Phe Cys Leu Arg Tyr Thr Lys Glu Glu Glu 
145                 150                 155                 160


Val Lys Arg Ile Val Ser Gly Ile Ile His His Thr Gln Ala Pro Lys 
                165                 170                 175


Leu Leu Lys Arg Leu Phe Leu Phe Ser Tyr Ala Thr Ala Ala Gln Asn 
            180                 185                 190


Asn Thr Val Thr Asp Pro Lys Asn His Thr Val Met Phe Asp Thr Leu 
        195                 200                 205


Lys Asp Trp Cys Trp Glu Leu Glu Arg Thr Lys Gly Asn Met Lys Tyr 
    210                 215                 220


Lys Ala Val Ser Val Asn Glu Gly Tyr Lys Val Cys Glu Arg Leu Pro 
225                 230                 235                 240


Ala Tyr Phe Val Val Pro Thr Pro Leu Pro Glu Glu Asn Val Gln Arg 
                245                 250                 255


Phe Gln Gly His Gly Ile Pro Ile Trp Cys Trp Ser Cys His Asn Gly 
            260                 265                 270


Ser Ala Leu Leu Lys Met Ser Ala Leu Pro Lys Glu Gln Asp Asp Gly 
        275                 280                 285


Ile Leu Gln Ile Gln Lys Ser Phe Leu Asp Gly Ile Tyr Lys Thr Ile 
    290                 295                 300


His Arg Pro Pro Tyr Glu Ile Val Lys Thr Glu Asp Leu Ser Ser Asn 
305                 310                 315                 320


Phe Leu Ser Leu Gln Glu Ile Gln Thr Ala Tyr Ser Lys Phe Lys Gln 
                325                 330                 335


Leu Phe Leu Ile Asp Asn Ser Thr Glu Phe Trp Asp Thr Asp Ile Lys 
            340                 345                 350


Trp Phe Ser Leu Leu Glu Ser Ser Ser Trp Leu Asp Ile Ile Arg Arg 
        355                 360                 365


Cys Leu Lys Lys Ala Ile Glu Ile Thr Glu Cys Met Glu Ala Gln Asn 
    370                 375                 380


Met Asn Val Leu Leu Leu Glu Glu Asn Ala Ser Asp Leu Cys Cys Leu 
385                 390                 395                 400


Ile Ser Ser Leu Val Gln Leu Met Met Asp Pro His Cys Arg Thr Arg 
                405                 410                 415


Ile Gly Phe Gln Ser Leu Ile Gln Lys Glu Trp Val Met Gly Gly His 
            420                 425                 430


Cys Phe Leu Asp Arg Cys Asn His Leu Arg Gln Asn Asp Lys Glu Glu 
        435                 440                 445


His Gln Arg Gln Leu Ser Leu Pro Leu Thr Gln Ser Lys Ser Ser Pro 
    450                 455                 460


Lys Arg Gly Phe Phe Arg Glu Glu Thr Asp His Leu Ile Lys Asn Leu 
465                 470                 475                 480


Leu Gly Lys Arg Ile Ser Lys Leu Ile Asn Ser Ser Asp Glu Leu Gln 
                485                 490                 495


Asp Asn Phe Arg Glu Phe Tyr Asp Ser Trp His Ser Lys Ser Thr Asp 
            500                 505                 510


Tyr His Gly Leu Leu Leu Pro His Ile Glu Gly Pro Glu Ile Lys Val 
        515                 520                 525


Trp Ala Gln Arg Tyr Leu Arg Trp Ile Pro Glu Ala Gln Ile Leu Gly 
    530                 535                 540


Gly Gly Gln Val Ala Thr Leu Ser Lys Leu Leu Glu Met Met Glu Glu 
545                 550                 555                 560


Val Gln Ser Leu Gln Glu Lys Ile Asp Glu Arg His His Ser Gln Gln 
                565                 570                 575


Ala Pro Gln Ala Glu Ala Pro Cys Leu Leu Arg Asn Ser Ala Arg Leu 
            580                 585                 590


Ser Ser Leu Phe Pro Phe Ala Leu Leu Gln Arg His Ser Ser Lys Pro 
        595                 600                 605


Val Leu Pro Thr Ser Gly Trp Lys Ala Leu Gly Asp Glu Asp Asp Leu 
    610                 615                 620


Ala Lys Arg Glu Asp Glu Phe Val Asp Leu Gly Asp Val 
625                 630                 635


<210>  2674
<211>  2943
<212>  DNA
<213>  Homo sapiens

<400>  2674
gcgctatttc tttaaattct catctcttaa aatgtaaaga gattctgaga aatggccttg     60

gagtgaatag gttgacgcag tttttacttc tgataaataa gtccatgagc ttttttagtg    120

tatagccaaa agtatggatt ctcactaatg tcttttcagc tttcattatc atcttaagga    180

tttcatagtg gttccaaact agtttctttg aattgctgtt ggtagtctca tttaaacttt    240

taagtaaaag ctacaacatg gataagcctt aaatattatg ctaagtgaga gaagtcaaac    300

acagagccac gtattacatg attccatttg tataaaacgt ccatagtagg caaatctgta    360

gaaactggaa gtgatttagg ggttgccaag ggctaaaaga aagggagaat ggagaatgac    420

tactagtggc tatgtggttt cttttggaga tcatgaaaat gttctggaat taggtaatgg    480

tgattattga acaactttgt gaatatacta aaaactactg aattgtacag tttaaaaggg    540

tgaatcttac atgtgaatta tatctcaatt tttaaaaatc taaatacaaa tttttatcat    600

gagacccttc aaaacaccac tccctgcatt gggtttttgt tttgtttttt ttgttttttt    660

gtttgtgaag aaagatggtc tcactccatc actcagggtg ctagagtgca atggcgcaat    720

ctcagcttac tgcagccagt aaacgatccc aggctcaagc gatcctcccg cctcagtccc    780

ccaagtagct ggggccacca gcatgtgcca ccacatccag ctaatttttg gttttttggg    840

gttttttttg tagagacggg gttttgccat cttgcccagg ctggtcttta acccctgaac    900

tcaggcaatc tgcctcccaa agtgtttgga ttacagacgt gagccactgt gcccggccta    960

ttccttaatt ttgaatgttt ttatattata tgtaatattt attttctgtt tttgtgactt   1020

gttctatgta gctttttcag tctttaaaat tttttcagtc tttaaaattt tagtttgaaa   1080

atgagtaatt cctttggtaa gctgttaaac acatttttat gttgtatttt taggctatgg   1140

agttactagt agagaaagca atcagcagtg cttctagccc tcagagccct ggggatgcac   1200

tgagaagagt ttttgaatgc atttcttcag ggattattct taaaggtagt cctggacttc   1260

tggatccttg tgaaaaggat ccctttgata ccttggcaac aatgactgac cagcagcgtg   1320

aagacatcac atccagtgca cagtttgcat tgagactcct tgcattccgc cagatacaca   1380

aagttctagg catggatcca ttaccgcaaa tgagccaacg ttttaacatc cacaacaaca   1440

ggaaacgaag aagagatagt gatggagttg atggatttga agctgagggg aaaaaagaca   1500

aaaaagatta tgataacttt taaaaagtgt ctgtaaatct tcagtgttaa aaaaacagat   1560

gcccatttgt tggctgtttt tcattcataa taatgtctac attgaaaaat ttatcaagaa   1620

tttaaaggat ttcatggaag aaccaagttt ttctatgata ttaaaaaatg tacagtgtta   1680

ggtattattt gaatggaaag acacccaaaa aaaaaaatgt gctccgacta gggggaaaac   1740

agtagttccg attttttccc attattttta ttttattttc tggttgccct agcttccccc   1800

cctatttttg tgtcttttat taactagtgc attgtcttat taaatcttca ctgtatttaa   1860

tgcaggatgt gtgcttcagt tgctctgtgt attttgatat tttaatttag aggttttgtt   1920

tgctttttga cactagttgt aagttacttt gttatagatg gtatccttta ccccttctta   1980

atattttaca gcagtacgtt tttttgtaac gtgagactgc agagtttgtt tttctatatg   2040

tgaaggatta caacacaaaa agttatcctg ccattcgagt gctcagaact gaatgtttct   2100

gcagatcttg tggcatttgt ctctagtgtg atatataaag gtgtaattaa gacagagttc   2160

tgttaatcta atcaagtttg ctgttagttg tgcattagca gtataaaagc taatatatac   2220

tatatggtct tgcaacagtt ttaaagcctc tgcataattg ataataaaaa tgcatgacat   2280

tcttgttttt aatagacttt taaaatcata attttaggtt taacacgtag atctttgtac   2340

agttgacttt ttgacatagc aaggccaaaa ataactttct gaatattttt ttcttgtgta   2400

taagtggaaa gggcattttt cacatataag tgggctaacc aatattttca aaagaacttc   2460

atcattgtac aactaacaac agtaactagc ccttaattat ggtgacagtt ccttattggt   2520

gtgtgtgaga ttactctagc aactattaca gtataacaca gatgatcttc tccacacacc   2580

ccatcaccca gataatttac agttctgtta acagtgaggt tgataaagta ttactgataa   2640

aaaattatct aaggaaaaaa acagaaaatt atttggtgtg gccatcttac ctgcttatgt   2700

ctcctacaca aagctaaata ttctagcagt gatgtaatga aaaattacat cttactgttg   2760

atatatgtat gctctggtac acagatgtca ttttgttgtc acagcactac agtgaaatac   2820

acaaaaaatg aaattcatat aatgacttaa atgtattata tgttagaatt gacaacataa   2880

actacttttg ctttgaaatg atgtatgctt cagtaaaatc atattcaaat ttattgagta   2940

ctg                                                                 2943


<210>  2675
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  2675

Met Glu Leu Leu Val Glu Lys Ala Ile Ser Ser Ala Ser Ser Pro Gln 
1               5                   10                  15


Ser Pro Gly Asp Ala Leu Arg Arg Val Phe Glu Cys Ile Ser Ser Gly 
            20                  25                  30


Ile Ile Leu Lys Gly Ser Pro Gly Leu Leu Asp Pro Cys Glu Lys Asp 
        35                  40                  45


Pro Phe Asp Thr Leu Ala Thr Met Thr Asp Gln Gln Arg Glu Asp Ile 
    50                  55                  60


Thr Ser Ser Ala Gln Phe Ala Leu Arg Leu Leu Ala Phe Arg Gln Ile 
65                  70                  75                  80


His Lys Val Leu Gly Met Asp Pro Leu Pro Gln Met Ser Gln Arg Phe 
                85                  90                  95


Asn Ile His Asn Asn Arg Lys Arg Arg Arg Asp Ser Asp Gly Val Asp 
            100                 105                 110


Gly Phe Glu Ala Glu Gly Lys Lys Asp Lys Lys Asp Tyr Asp Asn Phe 
        115                 120                 125


<210>  2676
<211>  3120
<212>  DNA
<213>  Homo sapiens

<400>  2676
ttcggatttc gttttggtgg gtagggttta tatttccaga aattgtttat tatattacta     60

aattaataag ttaacctttt gttcctcata ttggattatg taaatttatt gaaaataact    120

ccgtggatat attaaagtgc caacaagctc tcaaatggct catgtgacac tgatgctacc    180

ttaaggaagt gtcttgctca cctggtcaaa cacccattcc tcactgcatt ttgccaattc    240

aatccatttt agatgtaacc tcgggtatgg tgaaagaccc accggacgtc ttggacaggc    300

aaaaatgcct tgacgctctg gctgctctac gccacgctaa gtggttccag gttcggaaca    360

tcattttact tttttcttgt agccttatga gagaagtagt tcagtacaac atgtttaact    420

gtgcttaaac atttcaaaag actgcccaag caatactatt ttaaattaaa tatcagaaaa    480

tatgttaaca tagaaagctg ggtatgatga tctgcatatt gcagttatta ttaatttgac    540

aatgaactta ggtttgggga gtgttttgta gttggggttt ttttattttt tatttttagt    600

ggctatattt aaagttgact tgtttaggaa catcacatgt ttgtgtatat atattatatt    660

ccataaggct gcagattaac tttgctttaa ataatggaat atgtgtttaa agctttgtgt    720

atagttttaa gatttttttc cccctctttc tctaagttaa taagtgtagg gagtgaaagg    780

tgaggaagca gctgtttggt ttagtgactt tgcagtcatg caaaggcaca gaagggaaac    840

caaacagatt tccttaacct ttcagtccct agacaaactt tttagctctt tactttttct    900

tttatttcta atgtaggcag actttttttt tttaagttta ctgttttaaa tgaacacagg    960

tcaaggttca caggggatca agaaatatta ttcttgtata atctgtttac tttgacctaa   1020

ataccagctt ttaaatacta accctggcat aaaatactgc tgtaaatggc agctcattga   1080

atccaatttt aagtgtgatt gtttttgttt ttatctgagc ttccattgaa cggtggtatt   1140

ttaacttttt ttcatcaagg gatatattca gtatttctaa gattaattca attggttttt   1200

atgttgctct caaggctaga gctaatggtc tgcagtcctg tgtgattatc atacgcattc   1260

ttcgagacct ctgtcagcga gttccaactt ggtctgattt tccaagctgg gctatggagt   1320

tactagtaga gaaagcaatc agcagtgctt ctagccctca gagccctggg gatgcactga   1380

gaagagtttt tgaatgcatt tcttcaggga ttattcttaa aggtagtcct ggacttctgg   1440

atccttgtga aaaggatccc tttgatacct tggcaacaat gactgaccag cagcgtgaag   1500

acatcacatc cagtgcacag tttgcattga gactccttgc attccgccag atacacaaag   1560

ttctaggcat ggatccatta ccgcaaatga gccaacgttt taacatccac aacaacagga   1620

aacgaagaag agatagtgat ggagttgatg gatttgaagc tgaggggaaa aaagacaaaa   1680

aagattatga taacttttaa aaagtgtctg taaatcttca gtgttaaaaa aacagatgcc   1740

catttgttgg ctgtttttca ttcataataa tgtctacatt gaaaaattta tcaagaattt   1800

aaaggatttc atggaagaac caagtttttc tatgatatta aaaaatgtac agtgttaggt   1860

attatttgaa tggaaagaca cccaaaaaaa aaaatgtgct ccgactaggg ggaaaacagt   1920

agttccgatt ttttcccatt atttttattt tattttctgg ttgccctagc ttccccccct   1980

atttttgtgt cttttattaa ctagtgcatt gtcttattaa atcttcactg tatttaatgc   2040

aggatgtgtg cttcagttgc tctgtgtatt ttgatatttt aatttagagg ttttgtttgc   2100

tttttgacac tagttgtaag ttactttgtt atagatggta tcctttaccc cttcttaata   2160

ttttacagca gtacgttttt ttgtaacgtg agactgcaga gtttgttttt ctatatgtga   2220

aggattacaa cacaaaaagt tatcctgcca ttcgagtgct cagaactgaa tgtttctgca   2280

gatcttgtgg catttgtctc tagtgtgata tataaaggtg taattaagac agagttctgt   2340

taatctaatc aagtttgctg ttagttgtgc attagcagta taaaagctaa tatatactat   2400

atggtcttgc aacagtttta aagcctctgc ataattgata ataaaaatgc atgacattct   2460

tgtttttaat agacttttaa aatcataatt ttaggtttaa cacgtagatc tttgtacagt   2520

tgactttttg acatagcaag gccaaaaata actttctgaa tatttttttc ttgtgtataa   2580

gtggaaaggg catttttcac atataagtgg gctaaccaat attttcaaaa gaacttcatc   2640

attgtacaac taacaacagt aactagccct taattatggt gacagttcct tattggtgtg   2700

tgtgagatta ctctagcaac tattacagta taacacagat gatcttctcc acacacccca   2760

tcacccagat aatttacagt tctgttaaca gtgaggttga taaagtatta ctgataaaaa   2820

attatctaag gaaaaaaaca gaaaattatt tggtgtggcc atcttacctg cttatgtctc   2880

ctacacaaag ctaaatattc tagcagtgat gtaatgaaaa attacatctt actgttgata   2940

tatgtatgct ctggtacaca gatgtcattt tgttgtcaca gcactacagt gaaatacaca   3000

aaaaatgaaa ttcatataat gacttaaatg tattatatgt tagaattgac aacataaact   3060

acttttgctt tgaaatgatg tatgcttcag taaaatcata ttcaaattta ttgagtactg   3120


<210>  2677
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  2677

Met Glu Leu Leu Val Glu Lys Ala Ile Ser Ser Ala Ser Ser Pro Gln 
1               5                   10                  15


Ser Pro Gly Asp Ala Leu Arg Arg Val Phe Glu Cys Ile Ser Ser Gly 
            20                  25                  30


Ile Ile Leu Lys Gly Ser Pro Gly Leu Leu Asp Pro Cys Glu Lys Asp 
        35                  40                  45


Pro Phe Asp Thr Leu Ala Thr Met Thr Asp Gln Gln Arg Glu Asp Ile 
    50                  55                  60


Thr Ser Ser Ala Gln Phe Ala Leu Arg Leu Leu Ala Phe Arg Gln Ile 
65                  70                  75                  80


His Lys Val Leu Gly Met Asp Pro Leu Pro Gln Met Ser Gln Arg Phe 
                85                  90                  95


Asn Ile His Asn Asn Arg Lys Arg Arg Arg Asp Ser Asp Gly Val Asp 
            100                 105                 110


Gly Phe Glu Ala Glu Gly Lys Lys Asp Lys Lys Asp Tyr Asp Asn Phe 
        115                 120                 125


<210>  2678
<211>  4705
<212>  DNA
<213>  Homo sapiens

<400>  2678
gttctccgct gaggaggagc ggggcagagg agggaggcag cgggtgagag ttcagagttc     60

agcagcagca gcccgagccc atgattccca tatgccctgt agtttctttc acctatgtgc    120

ccagccggct gggggaagat gccaaaatgg cgaccggcaa ctactttgga ttcacccaca    180

gcggctccac aatgtagcca gcagccagct tcgggtgtag cctattctca tccaactaca    240

gttgctagct acactgtcca tcaggctcca gtagctgctc acacagttac tgctgcctat    300

gcaccagcag ccgccacagt tgcagttgcc aggcctgctc cagtagctgt tgcagctgct    360

gcaacagctg ctgcttatgg aggctacccc actgcacaca cagcaactga ctatggttat    420

actcagaggc aacaagaagc accaccacca ccacccccag ctactacaca aaactaccag    480

gattcatact catatgtaag gtccacagct cctgctgtag cttatgatag taagcaatac    540

taccaacaac caacagcaac tgctgctgct gtagctgccg ctgcccaacc tcagccttct    600

gttgctgaaa cttactatca gacagccccc aaagcaggtt acagccaagg tgcaactcag    660

tatactcaag cccagcaaac tcgacaagtg acagccataa aaccagccac accaagtcca    720

gctaccacta ctttctccat ctatcctgta tcctccaccg tacagccagt agcagctgcg    780

gctactgtgg tgccatccta tactcagagt gctacttaca gtaccacagc agttacatat    840

tctggtacgt cttattcagg ttatgaagca gcagtgtatt cagctgcatc ttcctactat    900

caacagcagc agcagcaaca gaagcaggca gcagcagcag ctgctgctgc tgctgcaaca    960

gctgcctgga cagggaccac ctttactaaa aaagcaccat tccaaaataa acaactgaaa   1020

ccaaaacagc ctcccaaacc accacagatt cactattgtg atgtttgtaa gatcagctgt   1080

gctggaccac agacttataa agaacattta gaaggacaga aacataaaaa aaaagaagct   1140

gcattgaaag cctcacaaaa taccagcagc agcaacagtt ctactcgtgg gactcaaaat   1200

cagctacgtt gtgagctctg cgatgtgtct tgtacaggag cagatgcgta tgctgcccac   1260

attcgtggtg ctaagcatca gaaagtggtt aagttacaca caaaacttgg taaacccatt   1320

ccatcaacag aaccaaatgt tgttagccaa gctacttctt caacagctgt atctgcttca   1380

aagccgactg cctctccttc aagcattgca gcaaacaatt gtactgtgaa tacgtcatca   1440

gttgcaacgt cttcaatgaa gggtcttacg actacaggaa actcgtctct taatagcaca   1500

tctaacacta aagtatcagc agtgcctaca aatatggctg ccaagaaaac atctaccccc   1560

aaaataaatt ttgttggtgg taataagctg cagtcaacag gaaataaagc agaagacata   1620

aaaggaaccg aatgtgttaa aagtactcct gtcacttctg ctgtgcagat tcctgaagta   1680

aagcaagaca cagtgtcaga accagtcaca cctgcatctc ttgctgcttt acagagtgat   1740

gtgcagccag tgggccatga ttatgtggaa gaggtacgaa atgatgaagg aaaagtaatt   1800

cggttccatt gtaaattatg cgagtgcagc tttaatgatc ccaatgctaa ggagatgcac   1860

ttaaaagggc gaagacacag acttcaatat aaaaaaaaag taaatccaga tttgcaagta   1920

gaagtaaagc ctagtattcg agcaagaaag attcaagaag agaaaatgag gaagcaaatg   1980

cagaaggagg agtactggcg aagacgagaa gaagaggagc gttggagaat ggaaatgaga   2040

cgttatgaag aggacatgta ctggaggaga atggaggaag aacaacatca ttgggatgat   2100

cgccgccgaa tgccagatgg aggttatcct catggtcctc caggcccatt aggccttctg   2160

ggagtccgac caggcatgcc tcctcagcct caggggcctg cacccttacg tcgtcctgac   2220

tcatctgatg accgttatgt aatgacaaaa catgccacca tttatccaac tgaagaggag   2280

ttacaggcag ttcagaaaat tgtttctatt actgaacgtg ctttaaaact cgtttcagac   2340

agtttgtctg aacatgagaa gaacaagaac aaagagggag atgataagaa agagggaggt   2400

aaagacagag ctttgaaagg agttttgcga gtgggagtat tggcaaaagg attacttctc   2460

cgaggagata gaaatgtcaa ccttgttttg ctgtgctcag agaaaccttc aaagacatta   2520

ttaagccgta ttgcagaaaa cctacccaaa cagcttgctg ttataagccc tgagaagtat   2580

gacataaaat gtgctgtatc tgaagcggca ataattttga attcatgtgt ggaacccaaa   2640

atgcaagtca ctatcacact gacatctcca attattcgag aagagaacat gagggaagga   2700

gatgtaacct cgggtatggt gaaagaccca ccggacgtct tggacaggca aaaatgcctt   2760

gacgctctgg ctgctctacg ccacgctaag tggttccagg ctagagctaa tggtctgcag   2820

tcctgtgtga ttatcatacg cattcttcga gacctctgtc agcgagttcc aacttggtct   2880

gattttccaa gctgggctat ggagttacta gtagagaaag caatcagcag tgcttctagc   2940

cctcagagcc ctggggatgc actgagaaga gtttttgaat gcatttcttc agggattatt   3000

cttaaaggta gtcctggact tctggatcct tgtgaaaagg atccctttga taccttggca   3060

acaatgactg accagcagcg tgaagacatc acatccagtg cacagtttgc attgagactc   3120

cttgcattcc gccagataca caaagttcta ggcatggatc cattaccgca aatgagccaa   3180

cgttttaaca tccacaacaa caggaaacga agaagagata gtgatggagt tgatggattt   3240

gaagctgagg ggaaaaaaga caaaaaagat tatgataact tttaaaaagt gtctgtaaat   3300

cttcagtgtt aaaaaaacag atgcccattt gttggctgtt tttcattcat aataatgtct   3360

acattgaaaa atttatcaag aatttaaagg atttcatgga agaaccaagt ttttctatga   3420

tattaaaaaa tgtacagtgt taggtattat ttgaatggaa agacacccaa aaaaaaaaat   3480

gtgctccgac tagggggaaa acagtagttc cgattttttc ccattatttt tattttattt   3540

tctggttgcc ctagcttccc cccctatttt tgtgtctttt attaactagt gcattgtctt   3600

attaaatctt cactgtattt aatgcaggat gtgtgcttca gttgctctgt gtattttgat   3660

attttaattt agaggttttg tttgcttttt gacactagtt gtaagttact ttgttataga   3720

tggtatcctt taccccttct taatatttta cagcagtacg tttttttgta acgtgagact   3780

gcagagtttg tttttctata tgtgaaggat tacaacacaa aaagttatcc tgccattcga   3840

gtgctcagaa ctgaatgttt ctgcagatct tgtggcattt gtctctagtg tgatatataa   3900

aggtgtaatt aagacagagt tctgttaatc taatcaagtt tgctgttagt tgtgcattag   3960

cagtataaaa gctaatatat actatatggt cttgcaacag ttttaaagcc tctgcataat   4020

tgataataaa aatgcatgac attcttgttt ttaatagact tttaaaatca taattttagg   4080

tttaacacgt agatctttgt acagttgact ttttgacata gcaaggccaa aaataacttt   4140

ctgaatattt ttttcttgtg tataagtgga aagggcattt ttcacatata agtgggctaa   4200

ccaatatttt caaaagaact tcatcattgt acaactaaca acagtaacta gcccttaatt   4260

atggtgacag ttccttattg gtgtgtgtga gattactcta gcaactatta cagtataaca   4320

cagatgatct tctccacaca ccccatcacc cagataattt acagttctgt taacagtgag   4380

gttgataaag tattactgat aaaaaattat ctaaggaaaa aaacagaaaa ttatttggtg   4440

tggccatctt acctgcttat gtctcctaca caaagctaaa tattctagca gtgatgtaat   4500

gaaaaattac atcttactgt tgatatatgt atgctctggt acacagatgt cattttgttg   4560

tcacagcact acagtgaaat acacaaaaaa tgaaattcat ataatgactt aaatgtatta   4620

tatgttagaa ttgacaacat aaactacttt tgctttgaaa tgatgtatgc ttcagtaaaa   4680

tcatattcaa atttattgag tactg                                         4705


<210>  2679
<211>  1056
<212>  PRT
<213>  Homo sapiens

<400>  2679

Met Cys Pro Ala Gly Trp Gly Lys Met Pro Lys Trp Arg Pro Ala Thr 
1               5                   10                  15


Thr Leu Asp Ser Pro Thr Ala Ala Pro Gln Cys Ser Gln Gln Pro Ala 
            20                  25                  30


Ser Gly Val Ala Tyr Ser His Pro Thr Thr Val Ala Ser Tyr Thr Val 
        35                  40                  45


His Gln Ala Pro Val Ala Ala His Thr Val Thr Ala Ala Tyr Ala Pro 
    50                  55                  60


Ala Ala Ala Thr Val Ala Val Ala Arg Pro Ala Pro Val Ala Val Ala 
65                  70                  75                  80


Ala Ala Ala Thr Ala Ala Ala Tyr Gly Gly Tyr Pro Thr Ala His Thr 
                85                  90                  95


Ala Thr Asp Tyr Gly Tyr Thr Gln Arg Gln Gln Glu Ala Pro Pro Pro 
            100                 105                 110


Pro Pro Pro Ala Thr Thr Gln Asn Tyr Gln Asp Ser Tyr Ser Tyr Val 
        115                 120                 125


Arg Ser Thr Ala Pro Ala Val Ala Tyr Asp Ser Lys Gln Tyr Tyr Gln 
    130                 135                 140


Gln Pro Thr Ala Thr Ala Ala Ala Val Ala Ala Ala Ala Gln Pro Gln 
145                 150                 155                 160


Pro Ser Val Ala Glu Thr Tyr Tyr Gln Thr Ala Pro Lys Ala Gly Tyr 
                165                 170                 175


Ser Gln Gly Ala Thr Gln Tyr Thr Gln Ala Gln Gln Thr Arg Gln Val 
            180                 185                 190


Thr Ala Ile Lys Pro Ala Thr Pro Ser Pro Ala Thr Thr Thr Phe Ser 
        195                 200                 205


Ile Tyr Pro Val Ser Ser Thr Val Gln Pro Val Ala Ala Ala Ala Thr 
    210                 215                 220


Val Val Pro Ser Tyr Thr Gln Ser Ala Thr Tyr Ser Thr Thr Ala Val 
225                 230                 235                 240


Thr Tyr Ser Gly Thr Ser Tyr Ser Gly Tyr Glu Ala Ala Val Tyr Ser 
                245                 250                 255


Ala Ala Ser Ser Tyr Tyr Gln Gln Gln Gln Gln Gln Gln Lys Gln Ala 
            260                 265                 270


Ala Ala Ala Ala Ala Ala Ala Ala Ala Thr Ala Ala Trp Thr Gly Thr 
        275                 280                 285


Thr Phe Thr Lys Lys Ala Pro Phe Gln Asn Lys Gln Leu Lys Pro Lys 
    290                 295                 300


Gln Pro Pro Lys Pro Pro Gln Ile His Tyr Cys Asp Val Cys Lys Ile 
305                 310                 315                 320


Ser Cys Ala Gly Pro Gln Thr Tyr Lys Glu His Leu Glu Gly Gln Lys 
                325                 330                 335


His Lys Lys Lys Glu Ala Ala Leu Lys Ala Ser Gln Asn Thr Ser Ser 
            340                 345                 350


Ser Asn Ser Ser Thr Arg Gly Thr Gln Asn Gln Leu Arg Cys Glu Leu 
        355                 360                 365


Cys Asp Val Ser Cys Thr Gly Ala Asp Ala Tyr Ala Ala His Ile Arg 
    370                 375                 380


Gly Ala Lys His Gln Lys Val Val Lys Leu His Thr Lys Leu Gly Lys 
385                 390                 395                 400


Pro Ile Pro Ser Thr Glu Pro Asn Val Val Ser Gln Ala Thr Ser Ser 
                405                 410                 415


Thr Ala Val Ser Ala Ser Lys Pro Thr Ala Ser Pro Ser Ser Ile Ala 
            420                 425                 430


Ala Asn Asn Cys Thr Val Asn Thr Ser Ser Val Ala Thr Ser Ser Met 
        435                 440                 445


Lys Gly Leu Thr Thr Thr Gly Asn Ser Ser Leu Asn Ser Thr Ser Asn 
    450                 455                 460


Thr Lys Val Ser Ala Val Pro Thr Asn Met Ala Ala Lys Lys Thr Ser 
465                 470                 475                 480


Thr Pro Lys Ile Asn Phe Val Gly Gly Asn Lys Leu Gln Ser Thr Gly 
                485                 490                 495


Asn Lys Ala Glu Asp Ile Lys Gly Thr Glu Cys Val Lys Ser Thr Pro 
            500                 505                 510


Val Thr Ser Ala Val Gln Ile Pro Glu Val Lys Gln Asp Thr Val Ser 
        515                 520                 525


Glu Pro Val Thr Pro Ala Ser Leu Ala Ala Leu Gln Ser Asp Val Gln 
    530                 535                 540


Pro Val Gly His Asp Tyr Val Glu Glu Val Arg Asn Asp Glu Gly Lys 
545                 550                 555                 560


Val Ile Arg Phe His Cys Lys Leu Cys Glu Cys Ser Phe Asn Asp Pro 
                565                 570                 575


Asn Ala Lys Glu Met His Leu Lys Gly Arg Arg His Arg Leu Gln Tyr 
            580                 585                 590


Lys Lys Lys Val Asn Pro Asp Leu Gln Val Glu Val Lys Pro Ser Ile 
        595                 600                 605


Arg Ala Arg Lys Ile Gln Glu Glu Lys Met Arg Lys Gln Met Gln Lys 
    610                 615                 620


Glu Glu Tyr Trp Arg Arg Arg Glu Glu Glu Glu Arg Trp Arg Met Glu 
625                 630                 635                 640


Met Arg Arg Tyr Glu Glu Asp Met Tyr Trp Arg Arg Met Glu Glu Glu 
                645                 650                 655


Gln His His Trp Asp Asp Arg Arg Arg Met Pro Asp Gly Gly Tyr Pro 
            660                 665                 670


His Gly Pro Pro Gly Pro Leu Gly Leu Leu Gly Val Arg Pro Gly Met 
        675                 680                 685


Pro Pro Gln Pro Gln Gly Pro Ala Pro Leu Arg Arg Pro Asp Ser Ser 
    690                 695                 700


Asp Asp Arg Tyr Val Met Thr Lys His Ala Thr Ile Tyr Pro Thr Glu 
705                 710                 715                 720


Glu Glu Leu Gln Ala Val Gln Lys Ile Val Ser Ile Thr Glu Arg Ala 
                725                 730                 735


Leu Lys Leu Val Ser Asp Ser Leu Ser Glu His Glu Lys Asn Lys Asn 
            740                 745                 750


Lys Glu Gly Asp Asp Lys Lys Glu Gly Gly Lys Asp Arg Ala Leu Lys 
        755                 760                 765


Gly Val Leu Arg Val Gly Val Leu Ala Lys Gly Leu Leu Leu Arg Gly 
    770                 775                 780


Asp Arg Asn Val Asn Leu Val Leu Leu Cys Ser Glu Lys Pro Ser Lys 
785                 790                 795                 800


Thr Leu Leu Ser Arg Ile Ala Glu Asn Leu Pro Lys Gln Leu Ala Val 
                805                 810                 815


Ile Ser Pro Glu Lys Tyr Asp Ile Lys Cys Ala Val Ser Glu Ala Ala 
            820                 825                 830


Ile Ile Leu Asn Ser Cys Val Glu Pro Lys Met Gln Val Thr Ile Thr 
        835                 840                 845


Leu Thr Ser Pro Ile Ile Arg Glu Glu Asn Met Arg Glu Gly Asp Val 
    850                 855                 860


Thr Ser Gly Met Val Lys Asp Pro Pro Asp Val Leu Asp Arg Gln Lys 
865                 870                 875                 880


Cys Leu Asp Ala Leu Ala Ala Leu Arg His Ala Lys Trp Phe Gln Ala 
                885                 890                 895


Arg Ala Asn Gly Leu Gln Ser Cys Val Ile Ile Ile Arg Ile Leu Arg 
            900                 905                 910


Asp Leu Cys Gln Arg Val Pro Thr Trp Ser Asp Phe Pro Ser Trp Ala 
        915                 920                 925


Met Glu Leu Leu Val Glu Lys Ala Ile Ser Ser Ala Ser Ser Pro Gln 
    930                 935                 940


Ser Pro Gly Asp Ala Leu Arg Arg Val Phe Glu Cys Ile Ser Ser Gly 
945                 950                 955                 960


Ile Ile Leu Lys Gly Ser Pro Gly Leu Leu Asp Pro Cys Glu Lys Asp 
                965                 970                 975


Pro Phe Asp Thr Leu Ala Thr Met Thr Asp Gln Gln Arg Glu Asp Ile 
            980                 985                 990


Thr Ser Ser Ala Gln Phe Ala Leu Arg Leu Leu Ala Phe Arg Gln Ile 
        995                 1000                1005


His Lys Val Leu Gly Met Asp Pro Leu Pro Gln Met Ser Gln Arg Phe 
    1010                1015                1020


Asn Ile His Asn Asn Arg Lys Arg Arg Arg Asp Ser Asp Gly Val Asp 
1025                1030                1035                1040


Gly Phe Glu Ala Glu Gly Lys Lys Asp Lys Lys Asp Tyr Asp Asn Phe 
                1045                1050                1055


<210>  2680
<211>  4377
<212>  DNA
<213>  Homo sapiens

<400>  2680
gcgggtgaga gttcagagtt cagcagcagc agcccgagcc catgattccc atatgccctg     60

tagtttcttt cacctatgtg cccagccggc tgggggaaga tgccaaaatg gcgaccggca    120

actactttgg attcacccac agcggctcca caatgtagcc agcagccagc ttcgggtgta    180

gcctattctc atccaactac agttgctagc tacactgtcc atcaggctcc agtagctgct    240

cacacagtta ctgctgccta tgcaccagca gccgccacag ttgcagttgc caggcctgct    300

ccagtagctg ttgcagctgc tgcaacagct gctgcttatg gaggctaccc cactgcacac    360

acagcaactg actatggtta tactcagagg caacaagaag caccaccacc accaccccca    420

gctactacac aaaactacca ggattcatac tcatatgtaa ggtccacagc tcctgctgta    480

gcttatgata gtaagcaata ctaccaacaa ccaacagcaa ctgctgctgc tgtagctgcc    540

gctgcccaac ctcagccttc tgttgctgaa acttactatc agacagcccc caaagcaggt    600

tacagccaag gtgcaactca gtatactcaa gcccagcaaa ctcgacaagt gacagccata    660

aaaccagcca caccaagtcc agctaccact actttctcca tctatcctgt atcctccacc    720

gtacagccag tagcagctgc ggctactgtg gtgccatcct atactcagag tgctacttac    780

agtaccacag cagttacata ttctggtacg tcttattcag gttatgaagc agcagtgtat    840

tcagctgcat cttcctacta tcaacagcag cagcagcaac agaagcaggc agcagcagca    900

gctgctgctg ctgctgcaac agctgcctgg acagggacca cctttactaa aaaagcacca    960

ttccaaaata aacaactgaa accaaaacag cctcccaaac caccacagat tcactattgt   1020

gatgtttgta agatcagctg tgctggacca cagacttata aagaacattt agaaggacag   1080

aaacataaaa aaaaagaagc tgcattgaaa gcctcacaaa ataccagcag cagcaacagt   1140

tctactcgtg ggactcaaaa tcagctacgt tgtgagctct gcgatgtgtc ttgtacagga   1200

gcagatgcgt atgctgccca cattcgtggt gctaagcatc agaaagtggt taagttacac   1260

acaaaacttg gtaaacccat tccatcaaca gaaccaaatg ttgttagcca agctacttct   1320

tcaacagctg tatctgcttc aaagccgact gcctctcctt caagcattgc agcaaacaat   1380

tgtactgtga atacgtcatc agttgcaacg tcttcaatga agggtcttac gactacagga   1440

aactcgtctc ttaatagcac atctaacact aaagtatcag cagtgcctac aaatatggct   1500

gccaagaaaa catctacccc caaaataaat tttgttggtg gtaataagct gcagtcaaca   1560

ggaaataaag cagaagacat aaaaggaacc gaatgtgtta aaagtactcc tgtcacttct   1620

gctgtgcaga ttcctgaagt aaagcaagac acagtgtcag aaccagtcac acctgcatct   1680

cttgctgctt tacagagtga tgtgcagcca gtgggccatg attatgtgga agaggtacga   1740

aatgatgaag gaaaagtaat tcggttccat tgtaaattat gcgagtgcag ctttaatgat   1800

cccaatgcta aggagatgca cttaaaaggg cgaagacaca gacttcaata taaaaaaaaa   1860

gtaaatccag atttgcaagt agaagtaaag cctagtattc gagcaagaaa gattcaagaa   1920

gagaaaatga ggaagcaaat gcagaaggag gagtactggc gaagacgaga agaagaggag   1980

cgttggagaa tggaaatgag acgttatgaa gaggacatgt actggaggag aatggaggaa   2040

gaacaacatc attgggatga tcgccgccga atgccagatg gaggttatcc tcatggtcct   2100

ccaggcccat taggccttct gggagtccga ccaggcatgc ctcctcagcc tcaggggcct   2160

gcacccttac gtcgtcctga ctcatctgat gaccgttatg taatgacaaa acatgccacc   2220

atttatccaa ctgaagagga gttacaggca gttcagaaaa ttgtttctat tactgaacgt   2280

gctttaaaac tcgtttcaga cagtttgtct gaacatgaga agaacaagaa caaagaggga   2340

gatgataaga aagagggagg taaagacaga gctttgaaag gagttttgcg agtgggagta   2400

ttggcaaaag gattacttct ccgaggagat agaaatgtca accttgtttt gctgtgctca   2460

gagaaacctt caaagacatt attaagccgt attgcagaaa acctacccaa acagcttgct   2520

gttataagcc ctgagaagta tgacataaaa tgtgctgtat ctgaagcggc aataattttg   2580

aattcatgtg tggaacccaa aatgcaagtc actatcacac tgacatctcc aattattcga   2640

gaagagaaca tgagggaagg agatgtaacc tcgggtatgg tgaaagaccc accggacgtc   2700

ttggacaggc aaaaatgcct tgacgctctg gctgctctac gccacgctaa gtggttccag   2760

gctagagcta atggtctgca gtcctgtgtg attatcatac gcattcttcg agacctctgt   2820

cagcgagttc caacttggtc tgattttcca agctgggcta tggagttact agtagagaaa   2880

gcaatcagca gtgcttctag ccctcagagc cctggggatg cactgagaag agtttttgaa   2940

tgcatttctt cagggattat tcttaaaggt agtcctggac ttctggatcc ttgtgaaaag   3000

gatccctttg ataccttggc aacaatgact gaccagcagc gtgaagacat cacatccagt   3060

gcacagtttg cattgagact ccttgcattc cgccagatac acaaagttct aggcatggat   3120

ccattaccgc aaatgagcca acgttttaac atccacaaca acaggaaacg aagaagagat   3180

agtgatggag ttgatggatt tgaagctgag gggaaaaaag acaaaaaaga ttatgataac   3240

ttttaaaaag tgtctgtaaa tcttcagtgt taaaaaaaca gatgcccatt tgttggctgt   3300

ttttcattca taataatgtc tacattgaaa aatttatcaa gaatttaaag gatttcatgg   3360

aagaaccaag tttttctatg atattaaaaa atgtacagtg ttaggtatta tttgaatgga   3420

aagacaccca aaaaaaaaaa tgtgctccga ctagggggaa aacagtagtt ccgatttttt   3480

cccattattt ttattttatt ttctggttgc cctagcttcc ccccctattt ttgtgtcttt   3540

tattaactag tgcattgtct tattaaatct tcactgtatt taatgcagga tgtgtgcttc   3600

agttgctctg tgtattttga tattttaatt tagaggtttt gtttgctttt tgacactagt   3660

tgtaagttac tttgttatag atggtatcct ttaccccttc ttaatatttt acagcagtac   3720

gtttttttgt aacgtgagac tgcagagttt gtttttctat atgtgaagga ttacaacaca   3780

aaaagttatc ctgccattcg agtgctcaga actgaatgtt tctgcagatc ttgtggcatt   3840

tgtctctagt gtgatatata aaggtgtaat taagacagag ttctgttaat ctaatcaagt   3900

ttgctgttag ttgtgcatta gcagtataaa agctaatata tactatatgg tcttgcaaca   3960

gttttaaagc ctctgcataa ttgataataa aaatgcatga cattcttgtt tttaatagac   4020

ttttaaaatc ataattttag gtttaacacg tagatctttg tacagttgac tttttgacat   4080

agcaaggcca aaaataactt tctgaatatt tttttcttgt gtataagtgg aaagggcatt   4140

tttcacatat aagtgggcta accaatattt tcaaaagaac ttcatcattg tacaactaac   4200

aacagtaact agcccttaat tatggtgaca gttccttatt ggtgtgtgtg agattactct   4260

agcaactatt acagtataac acagatgatc ttctccacac accccatcac ccagataatt   4320

tacagttctg ttaacagtga ggttgataaa gtattactga taaaaaatta tctaagg      4377


<210>  2681
<211>  1056
<212>  PRT
<213>  Homo sapiens

<400>  2681

Met Cys Pro Ala Gly Trp Gly Lys Met Pro Lys Trp Arg Pro Ala Thr 
1               5                   10                  15


Thr Leu Asp Ser Pro Thr Ala Ala Pro Gln Cys Ser Gln Gln Pro Ala 
            20                  25                  30


Ser Gly Val Ala Tyr Ser His Pro Thr Thr Val Ala Ser Tyr Thr Val 
        35                  40                  45


His Gln Ala Pro Val Ala Ala His Thr Val Thr Ala Ala Tyr Ala Pro 
    50                  55                  60


Ala Ala Ala Thr Val Ala Val Ala Arg Pro Ala Pro Val Ala Val Ala 
65                  70                  75                  80


Ala Ala Ala Thr Ala Ala Ala Tyr Gly Gly Tyr Pro Thr Ala His Thr 
                85                  90                  95


Ala Thr Asp Tyr Gly Tyr Thr Gln Arg Gln Gln Glu Ala Pro Pro Pro 
            100                 105                 110


Pro Pro Pro Ala Thr Thr Gln Asn Tyr Gln Asp Ser Tyr Ser Tyr Val 
        115                 120                 125


Arg Ser Thr Ala Pro Ala Val Ala Tyr Asp Ser Lys Gln Tyr Tyr Gln 
    130                 135                 140


Gln Pro Thr Ala Thr Ala Ala Ala Val Ala Ala Ala Ala Gln Pro Gln 
145                 150                 155                 160


Pro Ser Val Ala Glu Thr Tyr Tyr Gln Thr Ala Pro Lys Ala Gly Tyr 
                165                 170                 175


Ser Gln Gly Ala Thr Gln Tyr Thr Gln Ala Gln Gln Thr Arg Gln Val 
            180                 185                 190


Thr Ala Ile Lys Pro Ala Thr Pro Ser Pro Ala Thr Thr Thr Phe Ser 
        195                 200                 205


Ile Tyr Pro Val Ser Ser Thr Val Gln Pro Val Ala Ala Ala Ala Thr 
    210                 215                 220


Val Val Pro Ser Tyr Thr Gln Ser Ala Thr Tyr Ser Thr Thr Ala Val 
225                 230                 235                 240


Thr Tyr Ser Gly Thr Ser Tyr Ser Gly Tyr Glu Ala Ala Val Tyr Ser 
                245                 250                 255


Ala Ala Ser Ser Tyr Tyr Gln Gln Gln Gln Gln Gln Gln Lys Gln Ala 
            260                 265                 270


Ala Ala Ala Ala Ala Ala Ala Ala Ala Thr Ala Ala Trp Thr Gly Thr 
        275                 280                 285


Thr Phe Thr Lys Lys Ala Pro Phe Gln Asn Lys Gln Leu Lys Pro Lys 
    290                 295                 300


Gln Pro Pro Lys Pro Pro Gln Ile His Tyr Cys Asp Val Cys Lys Ile 
305                 310                 315                 320


Ser Cys Ala Gly Pro Gln Thr Tyr Lys Glu His Leu Glu Gly Gln Lys 
                325                 330                 335


His Lys Lys Lys Glu Ala Ala Leu Lys Ala Ser Gln Asn Thr Ser Ser 
            340                 345                 350


Ser Asn Ser Ser Thr Arg Gly Thr Gln Asn Gln Leu Arg Cys Glu Leu 
        355                 360                 365


Cys Asp Val Ser Cys Thr Gly Ala Asp Ala Tyr Ala Ala His Ile Arg 
    370                 375                 380


Gly Ala Lys His Gln Lys Val Val Lys Leu His Thr Lys Leu Gly Lys 
385                 390                 395                 400


Pro Ile Pro Ser Thr Glu Pro Asn Val Val Ser Gln Ala Thr Ser Ser 
                405                 410                 415


Thr Ala Val Ser Ala Ser Lys Pro Thr Ala Ser Pro Ser Ser Ile Ala 
            420                 425                 430


Ala Asn Asn Cys Thr Val Asn Thr Ser Ser Val Ala Thr Ser Ser Met 
        435                 440                 445


Lys Gly Leu Thr Thr Thr Gly Asn Ser Ser Leu Asn Ser Thr Ser Asn 
    450                 455                 460


Thr Lys Val Ser Ala Val Pro Thr Asn Met Ala Ala Lys Lys Thr Ser 
465                 470                 475                 480


Thr Pro Lys Ile Asn Phe Val Gly Gly Asn Lys Leu Gln Ser Thr Gly 
                485                 490                 495


Asn Lys Ala Glu Asp Ile Lys Gly Thr Glu Cys Val Lys Ser Thr Pro 
            500                 505                 510


Val Thr Ser Ala Val Gln Ile Pro Glu Val Lys Gln Asp Thr Val Ser 
        515                 520                 525


Glu Pro Val Thr Pro Ala Ser Leu Ala Ala Leu Gln Ser Asp Val Gln 
    530                 535                 540


Pro Val Gly His Asp Tyr Val Glu Glu Val Arg Asn Asp Glu Gly Lys 
545                 550                 555                 560


Val Ile Arg Phe His Cys Lys Leu Cys Glu Cys Ser Phe Asn Asp Pro 
                565                 570                 575


Asn Ala Lys Glu Met His Leu Lys Gly Arg Arg His Arg Leu Gln Tyr 
            580                 585                 590


Lys Lys Lys Val Asn Pro Asp Leu Gln Val Glu Val Lys Pro Ser Ile 
        595                 600                 605


Arg Ala Arg Lys Ile Gln Glu Glu Lys Met Arg Lys Gln Met Gln Lys 
    610                 615                 620


Glu Glu Tyr Trp Arg Arg Arg Glu Glu Glu Glu Arg Trp Arg Met Glu 
625                 630                 635                 640


Met Arg Arg Tyr Glu Glu Asp Met Tyr Trp Arg Arg Met Glu Glu Glu 
                645                 650                 655


Gln His His Trp Asp Asp Arg Arg Arg Met Pro Asp Gly Gly Tyr Pro 
            660                 665                 670


His Gly Pro Pro Gly Pro Leu Gly Leu Leu Gly Val Arg Pro Gly Met 
        675                 680                 685


Pro Pro Gln Pro Gln Gly Pro Ala Pro Leu Arg Arg Pro Asp Ser Ser 
    690                 695                 700


Asp Asp Arg Tyr Val Met Thr Lys His Ala Thr Ile Tyr Pro Thr Glu 
705                 710                 715                 720


Glu Glu Leu Gln Ala Val Gln Lys Ile Val Ser Ile Thr Glu Arg Ala 
                725                 730                 735


Leu Lys Leu Val Ser Asp Ser Leu Ser Glu His Glu Lys Asn Lys Asn 
            740                 745                 750


Lys Glu Gly Asp Asp Lys Lys Glu Gly Gly Lys Asp Arg Ala Leu Lys 
        755                 760                 765


Gly Val Leu Arg Val Gly Val Leu Ala Lys Gly Leu Leu Leu Arg Gly 
    770                 775                 780


Asp Arg Asn Val Asn Leu Val Leu Leu Cys Ser Glu Lys Pro Ser Lys 
785                 790                 795                 800


Thr Leu Leu Ser Arg Ile Ala Glu Asn Leu Pro Lys Gln Leu Ala Val 
                805                 810                 815


Ile Ser Pro Glu Lys Tyr Asp Ile Lys Cys Ala Val Ser Glu Ala Ala 
            820                 825                 830


Ile Ile Leu Asn Ser Cys Val Glu Pro Lys Met Gln Val Thr Ile Thr 
        835                 840                 845


Leu Thr Ser Pro Ile Ile Arg Glu Glu Asn Met Arg Glu Gly Asp Val 
    850                 855                 860


Thr Ser Gly Met Val Lys Asp Pro Pro Asp Val Leu Asp Arg Gln Lys 
865                 870                 875                 880


Cys Leu Asp Ala Leu Ala Ala Leu Arg His Ala Lys Trp Phe Gln Ala 
                885                 890                 895


Arg Ala Asn Gly Leu Gln Ser Cys Val Ile Ile Ile Arg Ile Leu Arg 
            900                 905                 910


Asp Leu Cys Gln Arg Val Pro Thr Trp Ser Asp Phe Pro Ser Trp Ala 
        915                 920                 925


Met Glu Leu Leu Val Glu Lys Ala Ile Ser Ser Ala Ser Ser Pro Gln 
    930                 935                 940


Ser Pro Gly Asp Ala Leu Arg Arg Val Phe Glu Cys Ile Ser Ser Gly 
945                 950                 955                 960


Ile Ile Leu Lys Gly Ser Pro Gly Leu Leu Asp Pro Cys Glu Lys Asp 
                965                 970                 975


Pro Phe Asp Thr Leu Ala Thr Met Thr Asp Gln Gln Arg Glu Asp Ile 
            980                 985                 990


Thr Ser Ser Ala Gln Phe Ala Leu Arg Leu Leu Ala Phe Arg Gln Ile 
        995                 1000                1005


His Lys Val Leu Gly Met Asp Pro Leu Pro Gln Met Ser Gln Arg Phe 
    1010                1015                1020


Asn Ile His Asn Asn Arg Lys Arg Arg Arg Asp Ser Asp Gly Val Asp 
1025                1030                1035                1040


Gly Phe Glu Ala Glu Gly Lys Lys Asp Lys Lys Asp Tyr Asp Asn Phe 
                1045                1050                1055


<210>  2682
<211>  793
<212>  DNA
<213>  Homo sapiens

<400>  2682
aagtgtgatt gtttttgttt ttatctgagc ttccattgaa cggtggtatt ttaacttttt     60

ttcatcaagg gatatattca gtatttctaa gattaattca attggttttt atgttgctct    120

caaggctaga gctaatggtc tgcagtcctg tgtgattatc atacgcattc ttcgagacct    180

ctgtcagcga gttccaactt ggtctgattt tccaagctgg gctatggagt tactagtaga    240

gaaagcaatc agcagtgctt ctagccctca gagccctggg gatgcactga gaagagtttt    300

tgaatgcatt tcttcaggga ttattcttaa aggtagtcct ggacttctgg atccttgtga    360

aaaggatccc tttgatacct tggcaacaat gactgaccag cagcgtgaag acatcacatc    420

cagtgcacag tttgcattga gactccttgc attccgccag atacacaaag ttctaggcat    480

ggatccatta ccgcaaatga gccaacgttt taacatccac aacaacagga aacgaagaag    540

agatagtgat ggagttgatg gatttgaagc tgaggggaaa aaagacaaaa aagattatga    600

taacttttaa aaagtgtctg taaatcttca gtgttaaaaa aacagatgcc catttgttgg    660

ctgtttttca ttcataataa tgtctacatt gaaaaattta tcaagaattt aaaggatttc    720

atggaagaac caagtttttc tatgatatta aaaaatgtac agtgttaggt attatttgaa    780

tggaaagaca ccc                                                       793


<210>  2683
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  2683

Met Glu Leu Leu Val Glu Lys Ala Ile Ser Ser Ala Ser Ser Pro Gln 
1               5                   10                  15


Ser Pro Gly Asp Ala Leu Arg Arg Val Phe Glu Cys Ile Ser Ser Gly 
            20                  25                  30


Ile Ile Leu Lys Gly Ser Pro Gly Leu Leu Asp Pro Cys Glu Lys Asp 
        35                  40                  45


Pro Phe Asp Thr Leu Ala Thr Met Thr Asp Gln Gln Arg Glu Asp Ile 
    50                  55                  60


Thr Ser Ser Ala Gln Phe Ala Leu Arg Leu Leu Ala Phe Arg Gln Ile 
65                  70                  75                  80


His Lys Val Leu Gly Met Asp Pro Leu Pro Gln Met Ser Gln Arg Phe 
                85                  90                  95


Asn Ile His Asn Asn Arg Lys Arg Arg Arg Asp Ser Asp Gly Val Asp 
            100                 105                 110


Gly Phe Glu Ala Glu Gly Lys Lys Asp Lys Lys Asp Tyr Asp Asn Phe 
        115                 120                 125


<210>  2684
<211>  3429
<212>  DNA
<213>  Homo sapiens

<400>  2684
gcgggtgaga gttcagagtt cagcagcagc agcccgagcc catgattccc atatgccctg     60

tagtttcttt cacctatgtg cccagccggc tgggggaaga tgccaaaatg gcgaccggca    120

actactttgg attcacccac agcggctcca caatgtagcc agcagccagc ttcgggtgta    180

gcctattctc atccaactac agttgctagc tacactgtcc atcaggctcc agtagctgct    240

cacacagtta ctgctgccta tgcaccagca gccgccacag ttgcagttgc caggcctgct    300

ccagtagctg ttgcagctgc tgcaacagct gctgcttatg gaggctaccc cactgcacac    360

acagcaactg actatggtta tactcagagg caacaagaag caccaccacc accaccccca    420

gctactacac aaaactacca ggattcatac tcatatgtaa ggtccacagc tcctgctgta    480

gcttatgata gtaagcaata ctaccaacaa ccaacagcaa ctgctgctgc tgtagctgcc    540

gctgcccaac ctcagccttc tgttgctgaa acttactatc agacagcccc caaagcaggt    600

tacagccaag gtgcaactca gtatactcaa gcccagcaaa ctcgacaagt gacagccata    660

aaaccagcca caccaagtcc agctaccact actttctcca tctatcctgt atcctccacc    720

gtacagccag tagcagctgc ggctactgtg gtgccatcct atactcagag tgctacttac    780

agtaccacag cagttacata ttctggtacg tcttattcag gttatgaagc agcagtgtat    840

tcagctgcat cttcctacta tcaacagcag cagcagcaac agaagcaggc agcagcagca    900

gctgctgctg ctgctgcaac agctgcctgg acagggacca cctttactaa aaaagcacca    960

ttccaaaata aacaactgaa accaaaacag cctcccaaac caccacagat tcactattgt   1020

gatgtttgta agatcagctg tgctggacca cagacttata aagaacattt agaaggacag   1080

aaacataaaa aaaaagaagc tgcattgaaa gcctcacaaa ataccagcag cagcaacagt   1140

tctactcgtg ggactcaaaa tcagctacgt tgtgagctct gcgatgtgtc ttgtacagga   1200

gcagatgcgt atgctgccca cattcgtggt gctaagcatc agaaagtggt taagttacac   1260

acaaaacttg gtaaacccat tccatcaaca gaaccaaatg ttgttagcca agctacttct   1320

tcaacagctg tatctgcttc aaagccgact gcctctcctt caagcattgc agcaaacaat   1380

tgtactgtga atacgtcatc agttgcaacg tcttcaatga agggtcttac gactacagga   1440

aactcgtctc ttaatagcac atctaacact aaagtatcag cagtgcctac aaatatggct   1500

gccaagaaaa catctacccc caaaataaat tttgttggtg gtaataagct gcagtcaaca   1560

ggaaataaag cagaagacat aaaaggaacc gaatgtgtta aaagtactcc tgtcacttct   1620

gctgtgcaga ttcctgaagt aaagcaagac acagtgtcag aaccagtcac acctgcatct   1680

cttgctgctt tacagagtga tgtgcagcca gtgggccatg attatgtgga agaggtacga   1740

aatgatgaag gaaaagtaat tcggttccat tgtaaattat gcgagtgcag ctttaatgat   1800

cccaatgcta aggagatgca cttaaaaggg cgaagacaca gacttcaata taaaaaaaaa   1860

gtaaatccag atttgcaagt agaagtaaag cctagtattc gagcaagaaa gattcaagaa   1920

gagaaaatga ggaagcaaat gcagaaggag gagtactggc gaagacgaga agaagaggag   1980

cgttggagaa tggaaatgag acgttatgaa gaggacatgt actggaggag aatggaggaa   2040

gaacaacatc attgggatga tcgccgccga atgccagatg gaggttatcc tcatggtcct   2100

ccaggcccat taggccttct gggagtccga ccaggcatgc ctcctcagcc tcaggggcct   2160

gcacccttac gtcgtcctga ctcatctgat gaccgttatg taatgacaaa acatgccacc   2220

atttatccaa ctgaagagga gttacaggca gttcagaaaa ttgtttctat tactgaacgt   2280

gctttaaaac tcgtttcaga cagtttgtct gaacatgaga agaacaagaa caaagaggga   2340

gatgataaga aagagggagg taaagacaga gctttgaaag gagttttgcg agtgggagta   2400

ttggcaaaag gattacttct ccgaggagat agaaatgtca accttgtttt gctgtgctca   2460

gagaaacctt caaagacatt attaagccgt attgcagaaa acctacccaa acagcttgct   2520

gttataagcc ctgagaagta tgacataaaa tgtgctgtat ctgaagcggc aataattttg   2580

aattcatgtg tggaacccaa aatgcaagtc actatcacac tgacatctcc aattattcga   2640

gaagagaaca tgagggaagg agatgtaacc tcgggtatgg tgaaagaccc accggacgtc   2700

ttggacaggc aaaaatgcct tgacgctctg gctgctctac gccacgctaa gtggttccag   2760

gctagagcta atggtctgca gtcctgtgtg attatcatac gcattcttcg agacctctgt   2820

cagcgagttc caacttggtc tgattttcca agctgggcta tggagttact agtagagaaa   2880

gcaatcagca gtgcttctag ccctcagagc cctggggatg cactgagaag agtttttgaa   2940

tgcatttctt cagggattat tcttaaaggt agtcctggac ttctggatcc ttgtgaaaag   3000

gatccctttg ataccttggc aacaatgact gaccagcagc gtgaagacat cacatccagt   3060

gcacagtttg cattgagact ccttgcattc cgccagatac acaaagttct aggcatggat   3120

ccattaccgc aaatgagcca acgttttaac atccacaaca acaggaaacg aagaagagat   3180

agtgatggag ttgatggatt tgaagctgag gggaaaaaag acaaaaaaga ttatgataac   3240

ttttaaaaag tgtctgtaaa tcttcagtgt taaaaaaaca gatgcccatt tgttggctgt   3300

ttttcattca taataatgtc tacattgaaa aatttatcaa gaatttaaag gatttcatgg   3360

aagaaccaag tttttctatg atattaaaaa atgtacagtg ttaggtatta tttgaatgga   3420

aagacaccc                                                           3429


<210>  2685
<211>  1056
<212>  PRT
<213>  Homo sapiens

<400>  2685

Met Cys Pro Ala Gly Trp Gly Lys Met Pro Lys Trp Arg Pro Ala Thr 
1               5                   10                  15


Thr Leu Asp Ser Pro Thr Ala Ala Pro Gln Cys Ser Gln Gln Pro Ala 
            20                  25                  30


Ser Gly Val Ala Tyr Ser His Pro Thr Thr Val Ala Ser Tyr Thr Val 
        35                  40                  45


His Gln Ala Pro Val Ala Ala His Thr Val Thr Ala Ala Tyr Ala Pro 
    50                  55                  60


Ala Ala Ala Thr Val Ala Val Ala Arg Pro Ala Pro Val Ala Val Ala 
65                  70                  75                  80


Ala Ala Ala Thr Ala Ala Ala Tyr Gly Gly Tyr Pro Thr Ala His Thr 
                85                  90                  95


Ala Thr Asp Tyr Gly Tyr Thr Gln Arg Gln Gln Glu Ala Pro Pro Pro 
            100                 105                 110


Pro Pro Pro Ala Thr Thr Gln Asn Tyr Gln Asp Ser Tyr Ser Tyr Val 
        115                 120                 125


Arg Ser Thr Ala Pro Ala Val Ala Tyr Asp Ser Lys Gln Tyr Tyr Gln 
    130                 135                 140


Gln Pro Thr Ala Thr Ala Ala Ala Val Ala Ala Ala Ala Gln Pro Gln 
145                 150                 155                 160


Pro Ser Val Ala Glu Thr Tyr Tyr Gln Thr Ala Pro Lys Ala Gly Tyr 
                165                 170                 175


Ser Gln Gly Ala Thr Gln Tyr Thr Gln Ala Gln Gln Thr Arg Gln Val 
            180                 185                 190


Thr Ala Ile Lys Pro Ala Thr Pro Ser Pro Ala Thr Thr Thr Phe Ser 
        195                 200                 205


Ile Tyr Pro Val Ser Ser Thr Val Gln Pro Val Ala Ala Ala Ala Thr 
    210                 215                 220


Val Val Pro Ser Tyr Thr Gln Ser Ala Thr Tyr Ser Thr Thr Ala Val 
225                 230                 235                 240


Thr Tyr Ser Gly Thr Ser Tyr Ser Gly Tyr Glu Ala Ala Val Tyr Ser 
                245                 250                 255


Ala Ala Ser Ser Tyr Tyr Gln Gln Gln Gln Gln Gln Gln Lys Gln Ala 
            260                 265                 270


Ala Ala Ala Ala Ala Ala Ala Ala Ala Thr Ala Ala Trp Thr Gly Thr 
        275                 280                 285


Thr Phe Thr Lys Lys Ala Pro Phe Gln Asn Lys Gln Leu Lys Pro Lys 
    290                 295                 300


Gln Pro Pro Lys Pro Pro Gln Ile His Tyr Cys Asp Val Cys Lys Ile 
305                 310                 315                 320


Ser Cys Ala Gly Pro Gln Thr Tyr Lys Glu His Leu Glu Gly Gln Lys 
                325                 330                 335


His Lys Lys Lys Glu Ala Ala Leu Lys Ala Ser Gln Asn Thr Ser Ser 
            340                 345                 350


Ser Asn Ser Ser Thr Arg Gly Thr Gln Asn Gln Leu Arg Cys Glu Leu 
        355                 360                 365


Cys Asp Val Ser Cys Thr Gly Ala Asp Ala Tyr Ala Ala His Ile Arg 
    370                 375                 380


Gly Ala Lys His Gln Lys Val Val Lys Leu His Thr Lys Leu Gly Lys 
385                 390                 395                 400


Pro Ile Pro Ser Thr Glu Pro Asn Val Val Ser Gln Ala Thr Ser Ser 
                405                 410                 415


Thr Ala Val Ser Ala Ser Lys Pro Thr Ala Ser Pro Ser Ser Ile Ala 
            420                 425                 430


Ala Asn Asn Cys Thr Val Asn Thr Ser Ser Val Ala Thr Ser Ser Met 
        435                 440                 445


Lys Gly Leu Thr Thr Thr Gly Asn Ser Ser Leu Asn Ser Thr Ser Asn 
    450                 455                 460


Thr Lys Val Ser Ala Val Pro Thr Asn Met Ala Ala Lys Lys Thr Ser 
465                 470                 475                 480


Thr Pro Lys Ile Asn Phe Val Gly Gly Asn Lys Leu Gln Ser Thr Gly 
                485                 490                 495


Asn Lys Ala Glu Asp Ile Lys Gly Thr Glu Cys Val Lys Ser Thr Pro 
            500                 505                 510


Val Thr Ser Ala Val Gln Ile Pro Glu Val Lys Gln Asp Thr Val Ser 
        515                 520                 525


Glu Pro Val Thr Pro Ala Ser Leu Ala Ala Leu Gln Ser Asp Val Gln 
    530                 535                 540


Pro Val Gly His Asp Tyr Val Glu Glu Val Arg Asn Asp Glu Gly Lys 
545                 550                 555                 560


Val Ile Arg Phe His Cys Lys Leu Cys Glu Cys Ser Phe Asn Asp Pro 
                565                 570                 575


Asn Ala Lys Glu Met His Leu Lys Gly Arg Arg His Arg Leu Gln Tyr 
            580                 585                 590


Lys Lys Lys Val Asn Pro Asp Leu Gln Val Glu Val Lys Pro Ser Ile 
        595                 600                 605


Arg Ala Arg Lys Ile Gln Glu Glu Lys Met Arg Lys Gln Met Gln Lys 
    610                 615                 620


Glu Glu Tyr Trp Arg Arg Arg Glu Glu Glu Glu Arg Trp Arg Met Glu 
625                 630                 635                 640


Met Arg Arg Tyr Glu Glu Asp Met Tyr Trp Arg Arg Met Glu Glu Glu 
                645                 650                 655


Gln His His Trp Asp Asp Arg Arg Arg Met Pro Asp Gly Gly Tyr Pro 
            660                 665                 670


His Gly Pro Pro Gly Pro Leu Gly Leu Leu Gly Val Arg Pro Gly Met 
        675                 680                 685


Pro Pro Gln Pro Gln Gly Pro Ala Pro Leu Arg Arg Pro Asp Ser Ser 
    690                 695                 700


Asp Asp Arg Tyr Val Met Thr Lys His Ala Thr Ile Tyr Pro Thr Glu 
705                 710                 715                 720


Glu Glu Leu Gln Ala Val Gln Lys Ile Val Ser Ile Thr Glu Arg Ala 
                725                 730                 735


Leu Lys Leu Val Ser Asp Ser Leu Ser Glu His Glu Lys Asn Lys Asn 
            740                 745                 750


Lys Glu Gly Asp Asp Lys Lys Glu Gly Gly Lys Asp Arg Ala Leu Lys 
        755                 760                 765


Gly Val Leu Arg Val Gly Val Leu Ala Lys Gly Leu Leu Leu Arg Gly 
    770                 775                 780


Asp Arg Asn Val Asn Leu Val Leu Leu Cys Ser Glu Lys Pro Ser Lys 
785                 790                 795                 800


Thr Leu Leu Ser Arg Ile Ala Glu Asn Leu Pro Lys Gln Leu Ala Val 
                805                 810                 815


Ile Ser Pro Glu Lys Tyr Asp Ile Lys Cys Ala Val Ser Glu Ala Ala 
            820                 825                 830


Ile Ile Leu Asn Ser Cys Val Glu Pro Lys Met Gln Val Thr Ile Thr 
        835                 840                 845


Leu Thr Ser Pro Ile Ile Arg Glu Glu Asn Met Arg Glu Gly Asp Val 
    850                 855                 860


Thr Ser Gly Met Val Lys Asp Pro Pro Asp Val Leu Asp Arg Gln Lys 
865                 870                 875                 880


Cys Leu Asp Ala Leu Ala Ala Leu Arg His Ala Lys Trp Phe Gln Ala 
                885                 890                 895


Arg Ala Asn Gly Leu Gln Ser Cys Val Ile Ile Ile Arg Ile Leu Arg 
            900                 905                 910


Asp Leu Cys Gln Arg Val Pro Thr Trp Ser Asp Phe Pro Ser Trp Ala 
        915                 920                 925


Met Glu Leu Leu Val Glu Lys Ala Ile Ser Ser Ala Ser Ser Pro Gln 
    930                 935                 940


Ser Pro Gly Asp Ala Leu Arg Arg Val Phe Glu Cys Ile Ser Ser Gly 
945                 950                 955                 960


Ile Ile Leu Lys Gly Ser Pro Gly Leu Leu Asp Pro Cys Glu Lys Asp 
                965                 970                 975


Pro Phe Asp Thr Leu Ala Thr Met Thr Asp Gln Gln Arg Glu Asp Ile 
            980                 985                 990


Thr Ser Ser Ala Gln Phe Ala Leu Arg Leu Leu Ala Phe Arg Gln Ile 
        995                 1000                1005


His Lys Val Leu Gly Met Asp Pro Leu Pro Gln Met Ser Gln Arg Phe 
    1010                1015                1020


Asn Ile His Asn Asn Arg Lys Arg Arg Arg Asp Ser Asp Gly Val Asp 
1025                1030                1035                1040


Gly Phe Glu Ala Glu Gly Lys Lys Asp Lys Lys Asp Tyr Asp Asn Phe 
                1045                1050                1055


<210>  2686
<211>  571
<212>  DNA
<213>  Homo sapiens

<400>  2686
agtgagggag tgcgaggcgg gagggggagg cggcgcggcc gcggcctggg ccccgccagg     60

gctgctctca cggcgcctct ctctttctct ccctgccctc cctcggcgtc tcggctcctc    120

tgtgtctctt gtcccgccat gggacccgac tcttcgtgcc cgccgcagtg cccagccggc    180

tgggggaaga tgccaaaatg gcgaccggca actactttgg attcacccac agcggggcgg    240

cggcggcggc ggctgcggcc caatatagcc agcagccagc ttcgggtgta gcctattctc    300

atccaactac agttgctagc tacactgtcc atcaggctcc agtagctgct cacacagtta    360

ctgctgccta tgcaccagca gccgccacag ttgcagttgc caggcctgct ccagtagctg    420

ttgcagctgc tgcaacagct gctgcttatg gaggctaccc cactgcacac acagcaactg    480

actatggtta tactcagagg caacaagaag caccaccacc accaccccca gctactacac    540

aaaactacca ggattacttc tccgaggaga t                                   571


<210>  2687
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  2687

Met Ala Thr Gly Asn Tyr Phe Gly Phe Thr His Ser Gly Ala Ala Ala 
1               5                   10                  15


Ala Ala Ala Ala Ala Gln Tyr Ser Gln Gln Pro Ala Ser Gly Val Ala 
            20                  25                  30


Tyr Ser His Pro Thr Thr Val Ala Ser Tyr Thr Val His Gln Ala Pro 
        35                  40                  45


Val Ala Ala His Thr Val Thr Ala Ala Tyr Ala Pro Ala Ala Ala Thr 
    50                  55                  60


Val Ala Val Ala Arg Pro Ala Pro Val Ala Val Ala Ala Ala Ala Thr 
65                  70                  75                  80


Ala Ala Ala Tyr Gly Gly Tyr Pro Thr Ala His Thr Ala Thr Asp Tyr 
                85                  90                  95


Gly Tyr Thr Gln Arg Gln Gln Glu Ala Pro Pro Pro Pro Pro Pro Ala 
            100                 105                 110


Thr Thr Gln Asn Tyr Gln Asp Tyr Phe Ser Glu 
        115                 120


<210>  2688
<211>  666
<212>  DNA
<213>  Homo sapiens

<400>  2688
gaggagcggg gcagaggagg gaggcagcgg gtgagagttc agagttcagc agcagcagcc     60

cgagcccatg attcccatat gccctgtagt ttctttcacc tatgtgccca gccggctggg    120

ggaagatgcc aaaatggcga ccggcaacta ctttggattc acccacagcg gctccacaat    180

gtagccagca gccagcttcg ggtgtagcct attctcatcc aactacagtt gctagctaca    240

ctgtccatca ggctccagta gctgctcaca cagttactgc tgcctatgca ccagcagccg    300

ccacagttgc agttgccagg cctgctccag tagctgttgc agctgctgca acagctgctg    360

cttatggagg ctaccccact gcacacacag caactgacta tggttatact cagaggcaac    420

aagaagcacc accaccacca cccccagcta ctacacaaaa ctaccaggat tcatactcat    480

atgtaaggtc cacagctcct gctgtagctt atgatagtaa gcaatactac caacaaccaa    540

cagcaactgc tgctgctgta gctgccgctg cccaacctca gccttctgtt gctgaaacct    600

tacgtcgtcc tgactcatct gatgaccgtt atgtaatgac aaaacatgcc accatttatc    660

caactg                                                               666


<210>  2689
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  2689

Met Cys Pro Ala Gly Trp Gly Lys Met Pro Lys Trp Arg Pro Ala Thr 
1               5                   10                  15


Thr Leu Asp Ser Pro Thr Ala Ala Pro Gln Cys Ser Gln Gln Pro Ala 
            20                  25                  30


Ser Gly Val Ala Tyr Ser His Pro Thr Thr Val Ala Ser Tyr Thr Val 
        35                  40                  45


His Gln Ala Pro Val Ala Ala His Thr Val Thr Ala Ala Tyr Ala Pro 
    50                  55                  60


Ala Ala Ala Thr Val Ala Val Ala Arg Pro Ala Pro Val Ala Val Ala 
65                  70                  75                  80


Ala Ala Ala Thr Ala Ala Ala Tyr Gly Gly Tyr Pro Thr Ala His Thr 
                85                  90                  95


Ala Thr Asp Tyr Gly Tyr Thr Gln Arg Gln Gln Glu Ala Pro Pro Pro 
            100                 105                 110


Pro Pro Pro Ala Thr Thr Gln Asn Tyr Gln Asp Ser Tyr Ser Tyr Val 
        115                 120                 125


Arg Ser Thr Ala Pro Ala Val Ala Tyr Asp Ser Lys Gln Tyr Tyr Gln 
    130                 135                 140


Gln Pro Thr Ala Thr Ala Ala Ala Val Ala Ala Ala Ala Gln Pro Gln 
145                 150                 155                 160


Pro Ser Val Ala Glu Thr Leu Arg Arg Pro Asp Ser Ser Asp Asp Arg 
                165                 170                 175


Tyr Val Met Thr Lys His Ala Thr Ile Tyr Pro 
            180                 185


<210>  2690
<211>  1910
<212>  DNA
<213>  Homo sapiens

<400>  2690
gttctccgct gaggaggagc ggggcagagg agggaggcag cgggtgagag ttcagagttc     60

agcagcagca gcccgagccc atgattccca tatgccctgt agtttctttc acctatgtgc    120

ccagccggct gggggaagat gccaaaatgg cgaccggcaa ctactttgga ttcacccaca    180

gcggggcggc ggcggcggcg gctgcggccc aatatagcca gcagccagct tcgggtgtag    240

cctattctca tccaactaca gttgctagct acactgtcca tcaggctcca gtagctgctc    300

acacagttac tgctgcctat gcaccagcag ccgccacagt tgcagttgcc aggcctgctc    360

cagtagctgt tgcagctgct gcaacagctg ctgcttatgg aggctacccc actgcacaca    420

cagcaactga ctatggttat actcagaggc aacaagaagc accaccacca ccacccccag    480

ctactacaca aaactaccag gattcatact catatgtaag gtccacagct cctgctgtag    540

cttatgatag taagcaatac taccaacaac caacagcaac tgctgctgct gtagctgccg    600

ctgcccaacc tcagccttct gttgctgaaa cttactatca gacagccccc aaagcaggtt    660

acagccaagg tgcaactcag tatactcaag cccagcaaac tcgacaagtg acagccataa    720

aaccagccac accaagtcca gctaccacta ctttctccat ctatcctgta tcctccaccg    780

tacagccagt agcagctgcg gctactgtgg tgccatccta tactcagagt gctacttaca    840

gtaccacagc agttacatat tctggtacgt cttattcagg ttatgaagca gcagtgtatt    900

cagctgcatc ttcctactat caacagcagc agcagcaaca gaagcaggca gcagcagcag    960

ctgctgctgc tgctgcaaca gctgcctgga cagggaccac ctttactaaa aaagcaccat   1020

tccaaaataa acaactgaaa ccaaaacagc ctcccaaacc accacagatt cactattgtg   1080

atgtttgtaa gatcagctgt gctggaccac agacttataa agaacattta gaaggacaga   1140

aacataaaaa aaaagaagct gcattgaaag cctcacaaaa taccagcagc agcaacagtt   1200

ctactcgtgg gactcaaaat cagctacgtt gtgagctctg cgatgtgtct tgtacaggag   1260

cagatgcgta tgctgcccac attcgtggtg ctaagcatca gaaagtggtt aagttacaca   1320

caaaacttgg taaacccatt ccatcaacag aaccaaatgt tgttagccaa gctacttctt   1380

caacagctgt atctgcttca aagccgactg cctctccttc aagcattgca gcaaacaatt   1440

gtactgtgaa tacgtcatca gttgcaacgt cttcaatgaa gggtcttacg actacaggaa   1500

actcgtctct taatagcaca tctaacacta aagtatcagc agtgcctaca aatatggctg   1560

ccaagaaaac atctaccccc aaaataaatt ttgttggtgg taataagctg cagtcaacag   1620

gaaataaagc agaagacata aaaggaaccg aatgtgttaa aagtactcct gtcacttctg   1680

ctgtgcagat tcctgaagta aagcaagaca cagtgtcaga accagtcaca cctgcatctc   1740

ttgctgcttt acagagtgat gtgcagccag tgggccatga ttatgtggaa gaggtacgaa   1800

atgatgaagg aaaagtaatt cggttccatt gtaaattatg cgagtgcagc tttaatgatc   1860

ccaatgctaa ggagatgcac ttaaaagggc gaagacacag acttcaatat              1910


<210>  2691
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  2691

Met Ile Pro Ile Cys Pro Val Val Ser Phe Thr Tyr Val Pro Ser Arg 
1               5                   10                  15


Leu Gly Glu Asp Ala Lys Met Ala Thr Gly Asn Tyr Phe Gly Phe Thr 
            20                  25                  30


His Ser Gly Ala Ala Ala Ala Ala Ala Ala Ala Gln Tyr Ser Gln Gln 
        35                  40                  45


Pro Ala Ser Gly Val Ala Tyr Ser His Pro Thr Thr Val Ala Ser Tyr 
    50                  55                  60


Thr Val His Gln Ala Pro Val Ala Ala His Thr Val Thr Ala Ala Tyr 
65                  70                  75                  80


Ala Pro Ala Ala Ala Thr Val Ala Val Ala Arg Pro Ala Pro Val Ala 
                85                  90                  95


Val Ala Ala Ala Ala Thr Ala Ala Ala Tyr Gly Gly Tyr Pro Thr Ala 
            100                 105                 110


His Thr Ala Thr Asp Tyr Gly Tyr Thr Gln Arg Gln Gln Glu Ala Pro 
        115                 120                 125


Pro Pro Pro Pro Pro Ala Thr Thr Gln Asn Tyr Gln Asp Ser Tyr Ser 
    130                 135                 140


Tyr Val Arg Ser Thr Ala Pro Ala Val Ala Tyr Asp Ser Lys Gln Tyr 
145                 150                 155                 160


Tyr Gln Gln Pro Thr Ala Thr Ala Ala Ala Val Ala Ala Ala Ala Gln 
                165                 170                 175


Pro Gln Pro Ser Val Ala Glu Thr Tyr Tyr Gln Thr Ala Pro Lys Ala 
            180                 185                 190


Gly Tyr Ser Gln Gly Ala Thr Gln Tyr Thr Gln Ala Gln Gln Thr Arg 
        195                 200                 205


Gln Val Thr Ala Ile Lys Pro Ala Thr Pro Ser Pro Ala Thr Thr Thr 
    210                 215                 220


Phe Ser Ile Tyr Pro Val Ser Ser Thr Val Gln Pro Val Ala Ala Ala 
225                 230                 235                 240


Ala Thr Val Val Pro Ser Tyr Thr Gln Ser Ala Thr Tyr Ser Thr Thr 
                245                 250                 255


Ala Val Thr Tyr Ser Gly Thr Ser Tyr Ser Gly Tyr Glu Ala Ala Val 
            260                 265                 270


Tyr Ser Ala Ala Ser Ser Tyr Tyr Gln Gln Gln Gln Gln Gln Gln Lys 
        275                 280                 285


Gln Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Thr Ala Ala Trp Thr 
    290                 295                 300


Gly Thr Thr Phe Thr Lys Lys Ala Pro Phe Gln Asn Lys Gln Leu Lys 
305                 310                 315                 320


Pro Lys Gln Pro Pro Lys Pro Pro Gln Ile His Tyr Cys Asp Val Cys 
                325                 330                 335


Lys Ile Ser Cys Ala Gly Pro Gln Thr Tyr Lys Glu His Leu Glu Gly 
            340                 345                 350


Gln Lys His Lys Lys Lys Glu Ala Ala Leu Lys Ala Ser Gln Asn Thr 
        355                 360                 365


Ser Ser Ser Asn Ser Ser Thr Arg Gly Thr Gln Asn Gln Leu Arg Cys 
    370                 375                 380


Glu Leu Cys Asp Val Ser Cys Thr Gly Ala Asp Ala Tyr Ala Ala His 
385                 390                 395                 400


Ile Arg Gly Ala Lys His Gln Lys Val Val Lys Leu His Thr Lys Leu 
                405                 410                 415


Gly Lys Pro Ile Pro Ser Thr Glu Pro Asn Val Val Ser Gln Ala Thr 
            420                 425                 430


Ser Ser Thr Ala Val Ser Ala Ser Lys Pro Thr Ala Ser Pro Ser Ser 
        435                 440                 445


Ile Ala Ala Asn Asn Cys Thr Val Asn Thr Ser Ser Val Ala Thr Ser 
    450                 455                 460


Ser Met Lys Gly Leu Thr Thr Thr Gly Asn Ser Ser Leu Asn Ser Thr 
465                 470                 475                 480


Ser Asn Thr Lys Val Ser Ala Val Pro Thr Asn Met Ala Ala Lys Lys 
                485                 490                 495


Thr Ser Thr Pro Lys Ile Asn Phe Val Gly Gly Asn Lys Leu Gln Ser 
            500                 505                 510


Thr Gly Asn Lys Ala Glu Asp Ile Lys Gly Thr Glu Cys Val Lys Ser 
        515                 520                 525


Thr Pro Val Thr Ser Ala Val Gln Ile Pro Glu Val Lys Gln Asp Thr 
    530                 535                 540


Val Ser Glu Pro Val Thr Pro Ala Ser Leu Ala Ala Leu Gln Ser Asp 
545                 550                 555                 560


Val Gln Pro Val Gly His Asp Tyr Val Glu Glu Val Arg Asn Asp Glu 
                565                 570                 575


Gly Lys Val Ile Arg Phe His Cys Lys Leu Cys Glu Cys Ser Phe Asn 
            580                 585                 590


Asp Pro Asn Ala Lys Glu Met His Leu Lys Gly Arg Arg His Arg Leu 
        595                 600                 605


Gln 



<210>  2692
<211>  1354
<212>  DNA
<213>  Homo sapiens

<400>  2692
gttctccgct gaggaggagc ggggcagagg agggaggcag cgggtgagag ttcagagttc     60

agcagcagca gcccgagccc atgattccca tatgccctgt agtttctttc acctatgtgc    120

ccagccggct gggggaagat gccaaaatgg cgaccggcaa ctactttgga ttcacccaca    180

gcggggcggc ggcggcggcg gctgcggccc aatatagcca gcagccagct tcgggtgtag    240

cctattctca tccaactaca gttgctagct acactgtcca tcaggctcca gtagctgctc    300

acacagttac tgctgcctat gcaccagcag ccgccacagt tgcagttgcc aggcctgctc    360

cagtagctgt tgcagctgct gcaacagctg ctgcttatgg aggctacccc actgcacaca    420

cagcaactga ctatggttat actcagaggc aacaagaagc accaccacca ccacccccag    480

ctactacaca aaactaccag gattcatact catatgtaag gtccacagct cctgctgtag    540

cttatgatag taagcaatac taccaacaac caacagcaac tgctgctgct gtagctgccg    600

ctgcccaacc tcagccttct gttgctgaaa cttactatca gacagccccc aaagcaggtt    660

acagccaagg tgcaactcag tatactcaag cccagcaaac tcgacaagtg acagccataa    720

aaccagccac accaagtcca gctaccacta ctttctccat ctatcctgta tcctccaccg    780

tacagccagt agcagctgcg gctactgtgg tgccatccta tactcagagt gctacttaca    840

gtaccacagc agttacatat tctggtacgt cttattcagg ttatgaagca gcagtgtatt    900

cagctgcatc ttcctactat caacagcagc agcagcaaca gaagcaggca gcagcagcag    960

ctgctgctgc tgctgcaaca gctgcctgga cagggaccac ctttactaaa aaagcaccat   1020

tccaaaataa acaactgaaa ccaaaacagc ctcccaaacc accacagatt cactattgtg   1080

atgtttgtaa gatcagctgt gctggaccac agacttataa agaacattta gaaggacaga   1140

aacataaaaa aaaagaagct gcattgaaag cctcacaaaa taccagcagc agcaacagtt   1200

ctactcgtgg gactcaaaat cagctacgtt gtgagctctg cgatgtgtct tgtacaggag   1260

cagatgcgta tgctgcccac attcgtggtg ctaagcatca gaaagtggtt aagttacaca   1320

caaaacttgg taaacccatt ccatcaacag aacc                               1354


<210>  2693
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  2693

Met Ile Pro Ile Cys Pro Val Val Ser Phe Thr Tyr Val Pro Ser Arg 
1               5                   10                  15


Leu Gly Glu Asp Ala Lys Met Ala Thr Gly Asn Tyr Phe Gly Phe Thr 
            20                  25                  30


His Ser Gly Ala Ala Ala Ala Ala Ala Ala Ala Gln Tyr Ser Gln Gln 
        35                  40                  45


Pro Ala Ser Gly Val Ala Tyr Ser His Pro Thr Thr Val Ala Ser Tyr 
    50                  55                  60


Thr Val His Gln Ala Pro Val Ala Ala His Thr Val Thr Ala Ala Tyr 
65                  70                  75                  80


Ala Pro Ala Ala Ala Thr Val Ala Val Ala Arg Pro Ala Pro Val Ala 
                85                  90                  95


Val Ala Ala Ala Ala Thr Ala Ala Ala Tyr Gly Gly Tyr Pro Thr Ala 
            100                 105                 110


His Thr Ala Thr Asp Tyr Gly Tyr Thr Gln Arg Gln Gln Glu Ala Pro 
        115                 120                 125


Pro Pro Pro Pro Pro Ala Thr Thr Gln Asn Tyr Gln Asp Ser Tyr Ser 
    130                 135                 140


Tyr Val Arg Ser Thr Ala Pro Ala Val Ala Tyr Asp Ser Lys Gln Tyr 
145                 150                 155                 160


Tyr Gln Gln Pro Thr Ala Thr Ala Ala Ala Val Ala Ala Ala Ala Gln 
                165                 170                 175


Pro Gln Pro Ser Val Ala Glu Thr Tyr Tyr Gln Thr Ala Pro Lys Ala 
            180                 185                 190


Gly Tyr Ser Gln Gly Ala Thr Gln Tyr Thr Gln Ala Gln Gln Thr Arg 
        195                 200                 205


Gln Val Thr Ala Ile Lys Pro Ala Thr Pro Ser Pro Ala Thr Thr Thr 
    210                 215                 220


Phe Ser Ile Tyr Pro Val Ser Ser Thr Val Gln Pro Val Ala Ala Ala 
225                 230                 235                 240


Ala Thr Val Val Pro Ser Tyr Thr Gln Ser Ala Thr Tyr Ser Thr Thr 
                245                 250                 255


Ala Val Thr Tyr Ser Gly Thr Ser Tyr Ser Gly Tyr Glu Ala Ala Val 
            260                 265                 270


Tyr Ser Ala Ala Ser Ser Tyr Tyr Gln Gln Gln Gln Gln Gln Gln Lys 
        275                 280                 285


Gln Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Thr Ala Ala Trp Thr 
    290                 295                 300


Gly Thr Thr Phe Thr Lys Lys Ala Pro Phe Gln Asn Lys Gln Leu Lys 
305                 310                 315                 320


Pro Lys Gln Pro Pro Lys Pro Pro Gln Ile His Tyr Cys Asp Val Cys 
                325                 330                 335


Lys Ile Ser Cys Ala Gly Pro Gln Thr Tyr Lys Glu His Leu Glu Gly 
            340                 345                 350


Gln Lys His Lys Lys Lys Glu Ala Ala Leu Lys Ala Ser Gln Asn Thr 
        355                 360                 365


Ser Ser Ser Asn Ser Ser Thr Arg Gly Thr Gln Asn Gln Leu Arg Cys 
    370                 375                 380


Glu Leu Cys Asp Val Ser Cys Thr Gly Ala Asp Ala Tyr Ala Ala His 
385                 390                 395                 400


Ile Arg Gly Ala Lys His Gln Lys Val Val Lys Leu His Thr Lys Leu 
                405                 410                 415


Gly Lys Pro Ile Pro Ser Thr 
            420


<210>  2694
<211>  644
<212>  DNA
<213>  Homo sapiens

<400>  2694
agtgcggtcg gaggcggcgg tctgttctcc gctgaggagg agcggggcag aggagggagg     60

cagcgggtga gagttcagag ttcagcagca gcagcccgag cccatgattc ccatatgccc    120

tgtagtttct ttcacctatg tgcccagccg gctgggggaa gatgccaaaa tggcgaccgg    180

caactacttt ggattcaccc acagcggggc ggcggcggcg gcggctgcgg cccaatatag    240

ccagcagcca gcttcgggtg tagcctattc tcatccaact acagttgcta gctacactgt    300

ccatcaggct ccagtagctg ctcacacagt tactgctgcc tatgcaccag cagccgccac    360

agttgcagtt gccaggcctg ctccagtagc tgttgcagct gctgcaacag ctgctgctta    420

tggaggctac cccactgcac acacagcaac tgactatggt tatactcaga ggcaacaaga    480

agcaccacca ccaccacccc cagctactac acaaaactac caggattcat actcatatgt    540

aaggtccaca gctcctgctg tagcttatga tagtaagcaa tactaccaac aaccaacagc    600

aactgctgct gctgtagctg ccgctgccca acctcagcct tctg                     644


<210>  2695
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  2695

Met Ile Pro Ile Cys Pro Val Val Ser Phe Thr Tyr Val Pro Ser Arg 
1               5                   10                  15


Leu Gly Glu Asp Ala Lys Met Ala Thr Gly Asn Tyr Phe Gly Phe Thr 
            20                  25                  30


His Ser Gly Ala Ala Ala Ala Ala Ala Ala Ala Gln Tyr Ser Gln Gln 
        35                  40                  45


Pro Ala Ser Gly Val Ala Tyr Ser His Pro Thr Thr Val Ala Ser Tyr 
    50                  55                  60


Thr Val His Gln Ala Pro Val Ala Ala His Thr Val Thr Ala Ala Tyr 
65                  70                  75                  80


Ala Pro Ala Ala Ala Thr Val Ala Val Ala Arg Pro Ala Pro Val Ala 
                85                  90                  95


Val Ala Ala Ala Ala Thr Ala Ala Ala Tyr Gly Gly Tyr Pro Thr Ala 
            100                 105                 110


His Thr Ala Thr Asp Tyr Gly Tyr Thr Gln Arg Gln Gln Glu Ala Pro 
        115                 120                 125


Pro Pro Pro Pro Pro Ala Thr Thr Gln Asn Tyr Gln Asp Ser Tyr Ser 
    130                 135                 140


Tyr Val Arg Ser Thr Ala Pro Ala Val Ala Tyr Asp Ser Lys Gln Tyr 
145                 150                 155                 160


Tyr Gln Gln Pro Thr Ala Thr Ala Ala Ala Val Ala Ala Ala Ala Gln 
                165                 170                 175


Pro Gln Pro 



<210>  2696
<211>  566
<212>  DNA
<213>  Homo sapiens

<400>  2696
gttctccgct gaggaggagc ggggcagagg agggaggcag cgggtgagag ttcagagttc     60

agcagcagca gcccgagccc atgattccca tatgccctgt agtttctttc acctatgtgc    120

ccagccggct gggggaagat gccaaaatgg cgaccggcaa ctactttgga ttcacccaca    180

gcggctccac aatgtagcca gcagccagct tcgggtgtag cctattctca tccaactaca    240

gttgctagct acactgtcca tcaggctcca gtagctgctc acacagttac tgctgcctat    300

gcaccagcag ccgccacagt tgcagttgcc aggcctgctc cagtagctgt tgcagctgct    360

gcaacagctg ctgcttatgg aggctacccc actgcacaca cagcaactga ctatggttat    420

actcagaggc aacaagaagc accaccacca ccacccccag ctactacaca aaactaccag    480

gattcatact catatgtaag gtccacagct cctgctgtag cttatgatag taagcaatac    540

taccaacaac caacagcaac tgctgc                                         566


<210>  2697
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  2697

Met Cys Pro Ala Gly Trp Gly Lys Met Pro Lys Trp Arg Pro Ala Thr 
1               5                   10                  15


Thr Leu Asp Ser Pro Thr Ala Ala Pro Gln Cys Ser Gln Gln Pro Ala 
            20                  25                  30


Ser Gly Val Ala Tyr Ser His Pro Thr Thr Val Ala Ser Tyr Thr Val 
        35                  40                  45


His Gln Ala Pro Val Ala Ala His Thr Val Thr Ala Ala Tyr Ala Pro 
    50                  55                  60


Ala Ala Ala Thr Val Ala Val Ala Arg Pro Ala Pro Val Ala Val Ala 
65                  70                  75                  80


Ala Ala Ala Thr Ala Ala Ala Tyr Gly Gly Tyr Pro Thr Ala His Thr 
                85                  90                  95


Ala Thr Asp Tyr Gly Tyr Thr Gln Arg Gln Gln Glu Ala Pro Pro Pro 
            100                 105                 110


Pro Pro Pro Ala Thr Thr Gln Asn Tyr Gln Asp Ser Tyr Ser Tyr Val 
        115                 120                 125


Arg Ser Thr Ala Pro Ala Val Ala Tyr Asp Ser Lys Gln Tyr Tyr Gln 
    130                 135                 140


Gln Pro Thr Ala Thr 
145


<210>  2698
<211>  464
<212>  DNA
<213>  Homo sapiens

<400>  2698
ccctggcgtg aaggtggcac tgtgactagc tcttgccgat ggaatgggag gagtcagtta     60

gaaattttca tatggtcaaa atacccatgg aatatatgag tggcagcagt aaacaatcct    120

tgaagttctt gcttgtttaa cttgactgtt ggtgatgccc aatgaggccc tgtctgctcc    180

aagcaaatta cataaaaaag atgtgaataa aaactcatca aatactaaca gagactgtgt    240

ctaagatgcc aattgaagac tggaacagcc atatgagtgt ggggtattcc tggaaacctg    300

ttctagtagg cactggagaa gacacaggaa cctctcaata cagaatagac acactttgca    360

ctcagtaata atgcactaat tgacgaatat attgacggag tgttggtttg cttcacaatc    420

tgctggtaaa catattcatt tttgggtgaa tttcaggcct tata                     464


<210>  2699
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  2699

Met Glu Trp Glu Glu Ser Val Arg Asn Phe His Met Val Lys Ile Pro 
1               5                   10                  15


Met Glu Tyr Met Ser Gly Ser Ser Lys Gln Ser Leu Lys Phe Leu Leu 
            20                  25                  30


Val 



<210>  2700
<211>  1173
<212>  DNA
<213>  Homo sapiens

<400>  2700
agggcctgtc cctctcactt ccactcgatt gtaatttcat ccccgggccg gtcgagcctc     60

cctccctccc gcggccagcc cttccctccc agtcggcctc cttcgtcgcc cccgcccccg    120

cgaaaagccc tgcagcttgc agccggcttc actcgcgcac gccgacctcc cggctgcagt    180

cctacctctt ggaactaccc gtgtttccgg gcccagccct cgcagccccc cacctcctcg    240

ccccggcccg gggatccgtt ggggccgcgt cccccacgcg cccccggaga cgccctttcc    300

gtgtgcgccc gggacttggt gaaactttgc aggcgccggc tgcgaaatgg atttaatccg    360

aggcgtcttg ctccggctcc tgctcctggc ttccagcctc ggacccggcg cggtgtcgct    420

ccgagcggcc atccgaaaac caggcaaggt agggcctcct cttgacatca agctgggcgc    480

attgaactgt acggctttca gcatccagtg gaaaatgcca aggcatcctg gaagtcccat    540

ccttgggtac actgtctttt actctgaggt tggcgcagat aaatccctgc aggagcagtt    600

gcacagcgtg cctctcagcc gggacatccc gaccacggag gaagtgattg gagatttgaa    660

accaggcact gaatatcgtg tgagcatagc agcttacagc caggctggca aagggcggct    720

gagctctcct cggcatgtca ccactttgtc ccaagattcc tgcctgcctc ctgcagctcc    780

ccagcagcca catgtcattg tggtttcgga ttctgaggtg gccctgtctt ggaaacctgg    840

agcgagtgaa ggaagcgccc ctattcagta ctattctgtg gaattcatca ggtaagtctg    900

tatgtcacat tcaaaagcca aatgtgtgct gggcgcggtg gctcacacct gtaatcccag    960

cactttggca ggctgaggcg ggcagatcac aaggtcagga gttcgagacc agcctgacca   1020

acatggtgaa accccgtctc tactaaaaat acaaaaatta gctgggcgtg atggcacgtg   1080

cctgtagtct cagctactca ggaggctgag gcaggagaaa tgcttgaacc caggaggtgg   1140

aggttgcagt gagccgagat catgccattg cac                                1173


<210>  2701
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  2701

Met Asp Leu Ile Arg Gly Val Leu Leu Arg Leu Leu Leu Leu Ala Ser 
1               5                   10                  15


Ser Leu Gly Pro Gly Ala Val Ser Leu Arg Ala Ala Ile Arg Lys Pro 
            20                  25                  30


Gly Lys Val Gly Pro Pro Leu Asp Ile Lys Leu Gly Ala Leu Asn Cys 
        35                  40                  45


Thr Ala Phe Ser Ile Gln Trp Lys Met Pro Arg His Pro Gly Ser Pro 
    50                  55                  60


Ile Leu Gly Tyr Thr Val Phe Tyr Ser Glu Val Gly Ala Asp Lys Ser 
65                  70                  75                  80


Leu Gln Glu Gln Leu His Ser Val Pro Leu Ser Arg Asp Ile Pro Thr 
                85                  90                  95


Thr Glu Glu Val Ile Gly Asp Leu Lys Pro Gly Thr Glu Tyr Arg Val 
            100                 105                 110


Ser Ile Ala Ala Tyr Ser Gln Ala Gly Lys Gly Arg Leu Ser Ser Pro 
        115                 120                 125


Arg His Val Thr Thr Leu Ser Gln Asp Ser Cys Leu Pro Pro Ala Ala 
    130                 135                 140


Pro Gln Gln Pro His Val Ile Val Val Ser Asp Ser Glu Val Ala Leu 
145                 150                 155                 160


Ser Trp Lys Pro Gly Ala Ser Glu Gly Ser Ala Pro Ile Gln Tyr Tyr 
                165                 170                 175


Ser Val Glu Phe Ile Arg 
            180


<210>  2702
<211>  3960
<212>  DNA
<213>  Homo sapiens

<400>  2702
agggcctgtc cctctcactt ccactcgatt gtaatttcat ccccgggccg gtcgagcctc     60

cctccctccc gcggccagcc cttccctccc agtcggcctc cttcgtcgcc cccgcccccg    120

cgaaaagccc tgcagcttgc agccggcttc actcgcgcac gccgacctcc cggctgcagt    180

cctacctctt ggaactaccc gtgtttccgg gcccagccct cgcagccccc cacctcctcg    240

ccccggcccg gggatccgtt ggggccgcgt cccccacgcg cccccggaga cgccctttcc    300

gtgtgcgccc gggacttggt gaaactttgc aggcgccggc tgcgaaatgg atttaatccg    360

aggcgtcttg ctccggctcc tgctcctggc ttccagcctc ggacccggcg cggtgtcgct    420

ccgagcggcc atccgaaaac caggcaaggt agggcctcct cttgacatca agctgggcgc    480

attgaactgt acggctttca gcatccagtg gaaaatgcca aggcatcctg gaagtcccat    540

ccttgggtac actgtctttt actctgaggt tggcgcagat aaatccctgc aggagcagtt    600

gcacagcgtg cctctcagcc gggacatccc gaccacggag gaagtgattg gagatttgaa    660

accaggcact gaatatcgtg tgagcatagc agcttacagc caggctggca aagggcggct    720

gagctctcct cggcatgtca ccactttgtc ccaagattcc tgcctgcctc ctgcagctcc    780

ccagcagcca catgtcattg tggtttcgga ttctgaggtg gccctgtctt ggaaacctgg    840

agcgagtgaa ggaagcgccc ctattcagta ctattctgtg gaattcatca ggccagattt    900

cgacaagaag tggacctcaa tccatgagcg gatccagatg gactccatgg ttatcaaggg    960

cctcgatcca gataccaact accagtttgc cgtgagggca atgaattccc atggccccag   1020

cccccgcagc tggcccagtg acatcatccg gaccctctgc cctgaggagg cgggaagtgg   1080

ccgctatgga ccccgttata tcaccgacat gggagctggt gaggatgatg aaggatttga   1140

agacgactta gatttggata tttcctttga ggaggttaaa ccacttcctg ctaccaaagg   1200

agggaataag aaatttttgg tggaaagcaa gaagatgtct atatctaacc caaagaccat   1260

ttctaggctc atccccccta cctcagcatc tctccctgtg accacggtgg ctccccagcc   1320

cattcccata cagagaaagg ggaagaatgg tgtggccata atgtcaaggc tctttgacat   1380

gccttgtgat gaaactctct gctctgctga cagcttctgt gtcaatgact acacctgggg   1440

gggctcgcga tgccagtgca ccctgggcaa aggtggtgag agctgctcag aagatattgt   1500

tatccagtat cctcagttct ttggccactc ctatgtaacg tttgaacctc tgaagaattc   1560

ttatcaggca tttcaaatta ctcttgaatt tagggcggag gcagaggatg gcttactgct   1620

ctactgtggg gagaacgaac acgggagggg ggatttcatg tccctggcta tcatccgacg   1680

ctccctgcag ttcaggttta attgtggaac tggggttgcc atcatcgtaa gtgagaccaa   1740

aatcaaacta gggggttggc acacggttat gctctacaga gatgggctga acgggctgct   1800

gcagctgaac aatggcaccc cagtgacagg ccagtctcag ggccaataca gtaaaattac   1860

tttccggaca cctctctatc ttggtggcgc tcccagcgct tactggttgg ttagagcaac   1920

agggacaaac cgaggctttc aaggctgtgt gcagtcgctc gctgtgaatg ggaggagaat   1980

tgacatgagg ccctggcccc tgggaaaagc actcagtggg gctgatgtgg gggaatgcag   2040

cagtggaatc tgtgatgagg cctcgtgcat ccatggtggc acctgcacag caatcaaagc   2100

cgactcctac atttgcctct gtccccttgg gtttaaaggt cgacactgtg aagatgcttt   2160

caccttgacc attcctcagt tcagagagtc tctgagatct tacgctgcaa ctccctggcc   2220

actggagccc cagcattacc tttccttcat ggaatttgag atcacatttc ggccagactc   2280

aggagatggt gtcctcctgt acagctatga cacaggcagc aaagacttcc tgtccatcaa   2340

cttggcaggg ggccacgtgg agttccgctt tgactgtggc tctgggaccg gtgtcctcag   2400

gagtgaagat cccctcaccc tgggcaactg gcacgagctt cgtgtatctc gcacagcaaa   2460

gaatggaatc ttacaggtgg ataagcagaa gatagtggag ggaatggcag agggaggctt   2520

cacacagatt aagtgcaaca cagacatttt cattggcgga gtccccaatt atgatgatgt   2580

gaagaagaac tcgggtgtcc tgaagccttt cagcgggagc atccagaaga tcatcctgaa   2640

tgaccgaacc atccatgtga agcatgactt cacctccgga gtgaatgtgg agaatgcggc   2700

ccacccctgt gtgagagccc cttgtgccca tgggggcagc tgccggccca ggaaggaggg   2760

ctatgactgt gactgcccct tgggctttga ggggcttcac tgccagaaag agtgtgggaa   2820

ctactgcctc aatacgatca tagaagccat tgagatcccg cagtttatcg gccgcagtta   2880

cctgacgtat gacaacccag atatcttgaa gagggtgtca ggatcaagat caaatgtgtt   2940

catgaggttt aaaacaactg ccaaggatgg ccttttgctg tggaggggag acagccccat   3000

gagacccaac agcgacttca tttccttggg ccttcgggat ggagccctcg tgttcagcta   3060

taacctgggc agtggtgtgg catccatcat ggtgaatggc tccttcaacg atggtcggtg   3120

gcaccgagtt aaggccgtta gggatggcca gtcaggaaag ataaccgtgg atgactatgg   3180

agccagaaca ggcaaatccc caggcatgat gcggcagctt aacatcaatg gagctctgta   3240

tgtgggtgga atgaaggaaa ttgctctgca cactaacagg caatatatga gagggctcgt   3300

gggctgtatc tctcacttca ccctgtccac cgattaccac atttccctcg tggaagatgc   3360

cgtggatggg aaaaacatca acacttgtgg agccaagtaa caccagctgg ccttgtccaa   3420

gggacagagc cttctattct gagaatccca ggggccctca gaccctgcct gatgctatat   3480

gcagaggccc agggaccagg tgtgtttcct ctcaccaaga agaaagtaca cactgatgag   3540

aaactgagaa ccaagacagg catccctggg tggcctttcc tgctgacact ccacgagctg   3600

acccagcaga attctctgtg taggaagcat cggactttgt ccattgaata tgtagcggct   3660

gccagagatc acacatcaat gcaaattcca gagcctgtct gctatagctc agtgactgtg   3720

ttgtgattca tagtacatta aaaagagaga gagagagaaa gaatcccaca gggcactatt   3780

aaaatacttc tctccttccc tgactcatga cactcttcct gacagcagaa tgactgtgtg   3840

accttgaact tcacatttcc cacattggcc cttggattgt tcggattaac cccttccact   3900

cctcactggc tggttcactg tgttctgact agtccataaa aataaagatg gaaggagatc   3960


<210>  2703
<211>  1017
<212>  PRT
<213>  Homo sapiens

<400>  2703

Met Asp Leu Ile Arg Gly Val Leu Leu Arg Leu Leu Leu Leu Ala Ser 
1               5                   10                  15


Ser Leu Gly Pro Gly Ala Val Ser Leu Arg Ala Ala Ile Arg Lys Pro 
            20                  25                  30


Gly Lys Val Gly Pro Pro Leu Asp Ile Lys Leu Gly Ala Leu Asn Cys 
        35                  40                  45


Thr Ala Phe Ser Ile Gln Trp Lys Met Pro Arg His Pro Gly Ser Pro 
    50                  55                  60


Ile Leu Gly Tyr Thr Val Phe Tyr Ser Glu Val Gly Ala Asp Lys Ser 
65                  70                  75                  80


Leu Gln Glu Gln Leu His Ser Val Pro Leu Ser Arg Asp Ile Pro Thr 
                85                  90                  95


Thr Glu Glu Val Ile Gly Asp Leu Lys Pro Gly Thr Glu Tyr Arg Val 
            100                 105                 110


Ser Ile Ala Ala Tyr Ser Gln Ala Gly Lys Gly Arg Leu Ser Ser Pro 
        115                 120                 125


Arg His Val Thr Thr Leu Ser Gln Asp Ser Cys Leu Pro Pro Ala Ala 
    130                 135                 140


Pro Gln Gln Pro His Val Ile Val Val Ser Asp Ser Glu Val Ala Leu 
145                 150                 155                 160


Ser Trp Lys Pro Gly Ala Ser Glu Gly Ser Ala Pro Ile Gln Tyr Tyr 
                165                 170                 175


Ser Val Glu Phe Ile Arg Pro Asp Phe Asp Lys Lys Trp Thr Ser Ile 
            180                 185                 190


His Glu Arg Ile Gln Met Asp Ser Met Val Ile Lys Gly Leu Asp Pro 
        195                 200                 205


Asp Thr Asn Tyr Gln Phe Ala Val Arg Ala Met Asn Ser His Gly Pro 
    210                 215                 220


Ser Pro Arg Ser Trp Pro Ser Asp Ile Ile Arg Thr Leu Cys Pro Glu 
225                 230                 235                 240


Glu Ala Gly Ser Gly Arg Tyr Gly Pro Arg Tyr Ile Thr Asp Met Gly 
                245                 250                 255


Ala Gly Glu Asp Asp Glu Gly Phe Glu Asp Asp Leu Asp Leu Asp Ile 
            260                 265                 270


Ser Phe Glu Glu Val Lys Pro Leu Pro Ala Thr Lys Gly Gly Asn Lys 
        275                 280                 285


Lys Phe Leu Val Glu Ser Lys Lys Met Ser Ile Ser Asn Pro Lys Thr 
    290                 295                 300


Ile Ser Arg Leu Ile Pro Pro Thr Ser Ala Ser Leu Pro Val Thr Thr 
305                 310                 315                 320


Val Ala Pro Gln Pro Ile Pro Ile Gln Arg Lys Gly Lys Asn Gly Val 
                325                 330                 335


Ala Ile Met Ser Arg Leu Phe Asp Met Pro Cys Asp Glu Thr Leu Cys 
            340                 345                 350


Ser Ala Asp Ser Phe Cys Val Asn Asp Tyr Thr Trp Gly Gly Ser Arg 
        355                 360                 365


Cys Gln Cys Thr Leu Gly Lys Gly Gly Glu Ser Cys Ser Glu Asp Ile 
    370                 375                 380


Val Ile Gln Tyr Pro Gln Phe Phe Gly His Ser Tyr Val Thr Phe Glu 
385                 390                 395                 400


Pro Leu Lys Asn Ser Tyr Gln Ala Phe Gln Ile Thr Leu Glu Phe Arg 
                405                 410                 415


Ala Glu Ala Glu Asp Gly Leu Leu Leu Tyr Cys Gly Glu Asn Glu His 
            420                 425                 430


Gly Arg Gly Asp Phe Met Ser Leu Ala Ile Ile Arg Arg Ser Leu Gln 
        435                 440                 445


Phe Arg Phe Asn Cys Gly Thr Gly Val Ala Ile Ile Val Ser Glu Thr 
    450                 455                 460


Lys Ile Lys Leu Gly Gly Trp His Thr Val Met Leu Tyr Arg Asp Gly 
465                 470                 475                 480


Leu Asn Gly Leu Leu Gln Leu Asn Asn Gly Thr Pro Val Thr Gly Gln 
                485                 490                 495


Ser Gln Gly Gln Tyr Ser Lys Ile Thr Phe Arg Thr Pro Leu Tyr Leu 
            500                 505                 510


Gly Gly Ala Pro Ser Ala Tyr Trp Leu Val Arg Ala Thr Gly Thr Asn 
        515                 520                 525


Arg Gly Phe Gln Gly Cys Val Gln Ser Leu Ala Val Asn Gly Arg Arg 
    530                 535                 540


Ile Asp Met Arg Pro Trp Pro Leu Gly Lys Ala Leu Ser Gly Ala Asp 
545                 550                 555                 560


Val Gly Glu Cys Ser Ser Gly Ile Cys Asp Glu Ala Ser Cys Ile His 
                565                 570                 575


Gly Gly Thr Cys Thr Ala Ile Lys Ala Asp Ser Tyr Ile Cys Leu Cys 
            580                 585                 590


Pro Leu Gly Phe Lys Gly Arg His Cys Glu Asp Ala Phe Thr Leu Thr 
        595                 600                 605


Ile Pro Gln Phe Arg Glu Ser Leu Arg Ser Tyr Ala Ala Thr Pro Trp 
    610                 615                 620


Pro Leu Glu Pro Gln His Tyr Leu Ser Phe Met Glu Phe Glu Ile Thr 
625                 630                 635                 640


Phe Arg Pro Asp Ser Gly Asp Gly Val Leu Leu Tyr Ser Tyr Asp Thr 
                645                 650                 655


Gly Ser Lys Asp Phe Leu Ser Ile Asn Leu Ala Gly Gly His Val Glu 
            660                 665                 670


Phe Arg Phe Asp Cys Gly Ser Gly Thr Gly Val Leu Arg Ser Glu Asp 
        675                 680                 685


Pro Leu Thr Leu Gly Asn Trp His Glu Leu Arg Val Ser Arg Thr Ala 
    690                 695                 700


Lys Asn Gly Ile Leu Gln Val Asp Lys Gln Lys Ile Val Glu Gly Met 
705                 710                 715                 720


Ala Glu Gly Gly Phe Thr Gln Ile Lys Cys Asn Thr Asp Ile Phe Ile 
                725                 730                 735


Gly Gly Val Pro Asn Tyr Asp Asp Val Lys Lys Asn Ser Gly Val Leu 
            740                 745                 750


Lys Pro Phe Ser Gly Ser Ile Gln Lys Ile Ile Leu Asn Asp Arg Thr 
        755                 760                 765


Ile His Val Lys His Asp Phe Thr Ser Gly Val Asn Val Glu Asn Ala 
    770                 775                 780


Ala His Pro Cys Val Arg Ala Pro Cys Ala His Gly Gly Ser Cys Arg 
785                 790                 795                 800


Pro Arg Lys Glu Gly Tyr Asp Cys Asp Cys Pro Leu Gly Phe Glu Gly 
                805                 810                 815


Leu His Cys Gln Lys Glu Cys Gly Asn Tyr Cys Leu Asn Thr Ile Ile 
            820                 825                 830


Glu Ala Ile Glu Ile Pro Gln Phe Ile Gly Arg Ser Tyr Leu Thr Tyr 
        835                 840                 845


Asp Asn Pro Asp Ile Leu Lys Arg Val Ser Gly Ser Arg Ser Asn Val 
    850                 855                 860


Phe Met Arg Phe Lys Thr Thr Ala Lys Asp Gly Leu Leu Leu Trp Arg 
865                 870                 875                 880


Gly Asp Ser Pro Met Arg Pro Asn Ser Asp Phe Ile Ser Leu Gly Leu 
                885                 890                 895


Arg Asp Gly Ala Leu Val Phe Ser Tyr Asn Leu Gly Ser Gly Val Ala 
            900                 905                 910


Ser Ile Met Val Asn Gly Ser Phe Asn Asp Gly Arg Trp His Arg Val 
        915                 920                 925


Lys Ala Val Arg Asp Gly Gln Ser Gly Lys Ile Thr Val Asp Asp Tyr 
    930                 935                 940


Gly Ala Arg Thr Gly Lys Ser Pro Gly Met Met Arg Gln Leu Asn Ile 
945                 950                 955                 960


Asn Gly Ala Leu Tyr Val Gly Gly Met Lys Glu Ile Ala Leu His Thr 
                965                 970                 975


Asn Arg Gln Tyr Met Arg Gly Leu Val Gly Cys Ile Ser His Phe Thr 
            980                 985                 990


Leu Ser Thr Asp Tyr His Ile Ser Leu Val Glu Asp Ala Val Asp Gly 
        995                 1000                1005


Lys Asn Ile Asn Thr Cys Gly Ala Lys 
    1010                1015


<210>  2704
<211>  3936
<212>  DNA
<213>  Homo sapiens

<400>  2704
agggcctgtc cctctcactt ccactcgatt gtaatttcat ccccgggccg gtcgagcctc     60

cctccctccc gcggccagcc cttccctccc agtcggcctc cttcgtcgcc cccgcccccg    120

cgaaaagccc tgcagcttgc agccggcttc actcgcgcac gccgacctcc cggctgcagt    180

cctacctctt ggaactaccc gtgtttccgg gcccagccct cgcagccccc cacctcctcg    240

ccccggcccg gggatccgtt ggggccgcgt cccccacgcg cccccggaga cgccctttcc    300

gtgtgcgccc gggacttggt gaaactttgc aggcgccggc tgcgaaatgg atttaatccg    360

aggcgtcttg ctccggctcc tgctcctggc ttccagcctc ggacccggcg cggtgtcgct    420

ccgagcggcc atccgaaaac caggcaaggt agggcctcct cttgacatca agctgggcgc    480

attgaactgt acggctttca gcatccagtg gaaaatgcca aggcatcctg gaagtcccat    540

ccttgggtac actgtctttt actctgaggt tggcgcagat aaatccctgc aggagcagtt    600

gcacagcgtg cctctcagcc gggacatccc gaccacggag gaagtgattg gagatttgaa    660

accaggcact gaatatcgtg tgagcatagc agcttacagc caggctggca aagggcggct    720

gagctctcct cggcatgtca ccactttgtc ccaagattcc tgcctgcctc ctgcagctcc    780

ccagcagcca catgtcattg tggtttcgga ttctgaggtg gccctgtctt ggaaacctgg    840

agcgagtgaa ggaagcgccc ctattcagta ctattctgtg gaattcatca ggccagattt    900

cgacaagaag tggacctcaa tccatgagcg gatccagatg gactccatgg ttatcaaggg    960

cctcgatcca gataccaact accagtttgc cgtgagggca atgaattccc atggccccag   1020

cccccgcagc tggcccagtg acatcatccg gaccctctgc cctgaggagg cgggaagtgg   1080

ccgctatgga ccccgttata tcaccgacat gggagctggt gaggatgatg aaggatttga   1140

agacgactta gatttggata tttcctttga ggaggttaaa ccacttcctg ctaccaaagg   1200

agggaataag aaatttttgg tggaaagcaa gaagatgtct atatctaacc caaagaccat   1260

ttctaggctc atccccccta cctcagcatc tctccctgtg accacggtgg ctccccagcc   1320

cattcccata cagagaaagg ggaagaatgg tgtggccata atgtcaaggc tctttgacat   1380

gccttgtgat gaaactctct gctctgctga cagcttctgt gtcaatgact acacctgggg   1440

gggctcgcga tgccagtgca ccctgggcaa aggtggtgag agctgctcag aagatattgt   1500

tatccagtat cctcagttct ttggccactc ctatgtaacg tttgaacctc tgaagaattc   1560

ttatcaggca tttcaaatta ctcttgaatt tagggcggag gcagaggatg gcttactgct   1620

ctactgtggg gagaacgaac acgggagggg ggatttcatg tccctggcta tcatccgacg   1680

ctccctgcag ttcaggttta attgtggaac tggggttgcc atcatcgtaa gtgagaccaa   1740

aatcaaacta gggggttggc acacggttat gctctacaga gatgggctga acgggctgct   1800

gcagctgaac aatggcaccc cagtgacagg ccagtctcag ggccaataca gtaaaattac   1860

tttccggaca cctctctatc ttggtggcgc tcccagcgct tactggttgg ttagagcaac   1920

agggacaaac cgaggctttc aaggctgtgt gcagtcgctc gctgtgaatg ggaggagaat   1980

tgacatgagg ccctggcccc tgggaaaagc actcagtggg gctgatgtgg gggaatgcag   2040

cagtggaatc tgtgatgagg cctcgtgcat ccatggtggc acctgcacag caatcaaagc   2100

cgactcctac atttgcctct gtccccttgg gtttaaaggt cgacactgtg aagatgcttt   2160

caccttgacc attcctcagt tcagagagtc tctgagatct tacgctgcaa ctccctggcc   2220

actggagccc cagcattacc tttccttcat ggaatttgag atcacatttc ggccagactc   2280

aggagatggt gtcctcctgt acagctatga cacaggcagc aaagacttcc tgtccatcaa   2340

cttggcaggg ggccacgtgg agttccgctt tgactgtggc tctgggaccg gtgtcctcag   2400

gagtgaagat cccctcaccc tgggcaactg gcacgagctt cgtgtatctc gcacagcaaa   2460

gaatggaatc ttacaggtgg ataagcagaa gatagtggag ggaatggcag agggaggctt   2520

cacacagatt aagtgcaaca cagacatttt cattggcgga gtccccaatt atgatgatgt   2580

gaagaagaac tcgggtgtcc tgaagccttt cagcgggagc atccagaaga tcatcctgaa   2640

tgaccgaacc atccatgtga agcatgactt cacctccgga gtgaatgtgg agaatgcggc   2700

ccacccctgt gtgagagccc cttgtgccca tgggggcagc tgccggccca ggaaggaggg   2760

ctatgactgt gactgcccct tgggctttga ggggcttcac tgccagaaag cgatcataga   2820

agccattgag atcccgcagt ttatcggccg cagttacctg acgtatgaca acccagatat   2880

cttgaagagg gtgtcaggat caagatcaaa tgtgttcatg aggtttaaaa caactgccaa   2940

ggatggcctt ttgctgtgga ggggagacag ccccatgaga cccaacagcg acttcatttc   3000

cttgggcctt cgggatggag ccctcgtgtt cagctataac ctgggcagtg gtgtggcatc   3060

catcatggtg aatggctcct tcaacgatgg tcggtggcac cgagttaagg ccgttaggga   3120

tggccagtca ggaaagataa ccgtggatga ctatggagcc agaacaggca aatccccagg   3180

catgatgcgg cagcttaaca tcaatggagc tctgtatgtg ggtggaatga aggaaattgc   3240

tctgcacact aacaggcaat atatgagagg gctcgtgggc tgtatctctc acttcaccct   3300

gtccaccgat taccacattt ccctcgtgga agatgccgtg gatgggaaaa acatcaacac   3360

ttgtggagcc aagtaacacc agctggcctt gtccaaggga cagagccttc tattctgaga   3420

atcccagggg ccctcagacc ctgcctgatg ctatatgcag aggcccaggg accaggtgtg   3480

tttcctctca ccaagaagaa agtacacact gatgagaaac tgagaaccaa gacaggcatc   3540

cctgggtggc ctttcctgct gacactccac gagctgaccc agcagaattc tctgtgtagg   3600

aagcatcgga ctttgtccat tgaatatgta gcggctgcca gagatcacac atcaatgcaa   3660

attccagagc ctgtctgcta tagctcagtg actgtgttgt gattcatagt acattaaaaa   3720

gagagagaga gagaaagaat cccacagggc actattaaaa tacttctctc cttccctgac   3780

tcatgacact cttcctgaca gcagaatgac tgtgtgacct tgaacttcac atttcccaca   3840

ttggcccttg gattgttcgg attaacccct tccactcctc actggctggt tcactgtgtt   3900

ctgactagtc cataaaaata aagatggaag gagatc                             3936


<210>  2705
<211>  1009
<212>  PRT
<213>  Homo sapiens

<400>  2705

Met Asp Leu Ile Arg Gly Val Leu Leu Arg Leu Leu Leu Leu Ala Ser 
1               5                   10                  15


Ser Leu Gly Pro Gly Ala Val Ser Leu Arg Ala Ala Ile Arg Lys Pro 
            20                  25                  30


Gly Lys Val Gly Pro Pro Leu Asp Ile Lys Leu Gly Ala Leu Asn Cys 
        35                  40                  45


Thr Ala Phe Ser Ile Gln Trp Lys Met Pro Arg His Pro Gly Ser Pro 
    50                  55                  60


Ile Leu Gly Tyr Thr Val Phe Tyr Ser Glu Val Gly Ala Asp Lys Ser 
65                  70                  75                  80


Leu Gln Glu Gln Leu His Ser Val Pro Leu Ser Arg Asp Ile Pro Thr 
                85                  90                  95


Thr Glu Glu Val Ile Gly Asp Leu Lys Pro Gly Thr Glu Tyr Arg Val 
            100                 105                 110


Ser Ile Ala Ala Tyr Ser Gln Ala Gly Lys Gly Arg Leu Ser Ser Pro 
        115                 120                 125


Arg His Val Thr Thr Leu Ser Gln Asp Ser Cys Leu Pro Pro Ala Ala 
    130                 135                 140


Pro Gln Gln Pro His Val Ile Val Val Ser Asp Ser Glu Val Ala Leu 
145                 150                 155                 160


Ser Trp Lys Pro Gly Ala Ser Glu Gly Ser Ala Pro Ile Gln Tyr Tyr 
                165                 170                 175


Ser Val Glu Phe Ile Arg Pro Asp Phe Asp Lys Lys Trp Thr Ser Ile 
            180                 185                 190


His Glu Arg Ile Gln Met Asp Ser Met Val Ile Lys Gly Leu Asp Pro 
        195                 200                 205


Asp Thr Asn Tyr Gln Phe Ala Val Arg Ala Met Asn Ser His Gly Pro 
    210                 215                 220


Ser Pro Arg Ser Trp Pro Ser Asp Ile Ile Arg Thr Leu Cys Pro Glu 
225                 230                 235                 240


Glu Ala Gly Ser Gly Arg Tyr Gly Pro Arg Tyr Ile Thr Asp Met Gly 
                245                 250                 255


Ala Gly Glu Asp Asp Glu Gly Phe Glu Asp Asp Leu Asp Leu Asp Ile 
            260                 265                 270


Ser Phe Glu Glu Val Lys Pro Leu Pro Ala Thr Lys Gly Gly Asn Lys 
        275                 280                 285


Lys Phe Leu Val Glu Ser Lys Lys Met Ser Ile Ser Asn Pro Lys Thr 
    290                 295                 300


Ile Ser Arg Leu Ile Pro Pro Thr Ser Ala Ser Leu Pro Val Thr Thr 
305                 310                 315                 320


Val Ala Pro Gln Pro Ile Pro Ile Gln Arg Lys Gly Lys Asn Gly Val 
                325                 330                 335


Ala Ile Met Ser Arg Leu Phe Asp Met Pro Cys Asp Glu Thr Leu Cys 
            340                 345                 350


Ser Ala Asp Ser Phe Cys Val Asn Asp Tyr Thr Trp Gly Gly Ser Arg 
        355                 360                 365


Cys Gln Cys Thr Leu Gly Lys Gly Gly Glu Ser Cys Ser Glu Asp Ile 
    370                 375                 380


Val Ile Gln Tyr Pro Gln Phe Phe Gly His Ser Tyr Val Thr Phe Glu 
385                 390                 395                 400


Pro Leu Lys Asn Ser Tyr Gln Ala Phe Gln Ile Thr Leu Glu Phe Arg 
                405                 410                 415


Ala Glu Ala Glu Asp Gly Leu Leu Leu Tyr Cys Gly Glu Asn Glu His 
            420                 425                 430


Gly Arg Gly Asp Phe Met Ser Leu Ala Ile Ile Arg Arg Ser Leu Gln 
        435                 440                 445


Phe Arg Phe Asn Cys Gly Thr Gly Val Ala Ile Ile Val Ser Glu Thr 
    450                 455                 460


Lys Ile Lys Leu Gly Gly Trp His Thr Val Met Leu Tyr Arg Asp Gly 
465                 470                 475                 480


Leu Asn Gly Leu Leu Gln Leu Asn Asn Gly Thr Pro Val Thr Gly Gln 
                485                 490                 495


Ser Gln Gly Gln Tyr Ser Lys Ile Thr Phe Arg Thr Pro Leu Tyr Leu 
            500                 505                 510


Gly Gly Ala Pro Ser Ala Tyr Trp Leu Val Arg Ala Thr Gly Thr Asn 
        515                 520                 525


Arg Gly Phe Gln Gly Cys Val Gln Ser Leu Ala Val Asn Gly Arg Arg 
    530                 535                 540


Ile Asp Met Arg Pro Trp Pro Leu Gly Lys Ala Leu Ser Gly Ala Asp 
545                 550                 555                 560


Val Gly Glu Cys Ser Ser Gly Ile Cys Asp Glu Ala Ser Cys Ile His 
                565                 570                 575


Gly Gly Thr Cys Thr Ala Ile Lys Ala Asp Ser Tyr Ile Cys Leu Cys 
            580                 585                 590


Pro Leu Gly Phe Lys Gly Arg His Cys Glu Asp Ala Phe Thr Leu Thr 
        595                 600                 605


Ile Pro Gln Phe Arg Glu Ser Leu Arg Ser Tyr Ala Ala Thr Pro Trp 
    610                 615                 620


Pro Leu Glu Pro Gln His Tyr Leu Ser Phe Met Glu Phe Glu Ile Thr 
625                 630                 635                 640


Phe Arg Pro Asp Ser Gly Asp Gly Val Leu Leu Tyr Ser Tyr Asp Thr 
                645                 650                 655


Gly Ser Lys Asp Phe Leu Ser Ile Asn Leu Ala Gly Gly His Val Glu 
            660                 665                 670


Phe Arg Phe Asp Cys Gly Ser Gly Thr Gly Val Leu Arg Ser Glu Asp 
        675                 680                 685


Pro Leu Thr Leu Gly Asn Trp His Glu Leu Arg Val Ser Arg Thr Ala 
    690                 695                 700


Lys Asn Gly Ile Leu Gln Val Asp Lys Gln Lys Ile Val Glu Gly Met 
705                 710                 715                 720


Ala Glu Gly Gly Phe Thr Gln Ile Lys Cys Asn Thr Asp Ile Phe Ile 
                725                 730                 735


Gly Gly Val Pro Asn Tyr Asp Asp Val Lys Lys Asn Ser Gly Val Leu 
            740                 745                 750


Lys Pro Phe Ser Gly Ser Ile Gln Lys Ile Ile Leu Asn Asp Arg Thr 
        755                 760                 765


Ile His Val Lys His Asp Phe Thr Ser Gly Val Asn Val Glu Asn Ala 
    770                 775                 780


Ala His Pro Cys Val Arg Ala Pro Cys Ala His Gly Gly Ser Cys Arg 
785                 790                 795                 800


Pro Arg Lys Glu Gly Tyr Asp Cys Asp Cys Pro Leu Gly Phe Glu Gly 
                805                 810                 815


Leu His Cys Gln Lys Ala Ile Ile Glu Ala Ile Glu Ile Pro Gln Phe 
            820                 825                 830


Ile Gly Arg Ser Tyr Leu Thr Tyr Asp Asn Pro Asp Ile Leu Lys Arg 
        835                 840                 845


Val Ser Gly Ser Arg Ser Asn Val Phe Met Arg Phe Lys Thr Thr Ala 
    850                 855                 860


Lys Asp Gly Leu Leu Leu Trp Arg Gly Asp Ser Pro Met Arg Pro Asn 
865                 870                 875                 880


Ser Asp Phe Ile Ser Leu Gly Leu Arg Asp Gly Ala Leu Val Phe Ser 
                885                 890                 895


Tyr Asn Leu Gly Ser Gly Val Ala Ser Ile Met Val Asn Gly Ser Phe 
            900                 905                 910


Asn Asp Gly Arg Trp His Arg Val Lys Ala Val Arg Asp Gly Gln Ser 
        915                 920                 925


Gly Lys Ile Thr Val Asp Asp Tyr Gly Ala Arg Thr Gly Lys Ser Pro 
    930                 935                 940


Gly Met Met Arg Gln Leu Asn Ile Asn Gly Ala Leu Tyr Val Gly Gly 
945                 950                 955                 960


Met Lys Glu Ile Ala Leu His Thr Asn Arg Gln Tyr Met Arg Gly Leu 
                965                 970                 975


Val Gly Cys Ile Ser His Phe Thr Leu Ser Thr Asp Tyr His Ile Ser 
            980                 985                 990


Leu Val Glu Asp Ala Val Asp Gly Lys Asn Ile Asn Thr Cys Gly Ala 
        995                 1000                1005


Lys 



<210>  2706
<211>  2849
<212>  DNA
<213>  Homo sapiens

<400>  2706
agggcctgtc cctctcactt ccactcgatt gtaatttcat ccccgggccg gtcgagcctc     60

cctccctccc gcggccagcc cttccctccc agtcggcctc cttcgtcgcc cccgcccccg    120

cgaaaagccc tgcagcttgc agccggcttc actcgcgcac gccgacctcc cggctgcagt    180

cctacctctt ggaactaccc gtgtttccgg gcccagccct cgcagccccc cacctcctcg    240

ccccggcccg gggatccgtt ggggccgcgt cccccacgcg cccccggaga cgccctttcc    300

gtgtgcgccc gggacttggt gaaactttgc aggcgccggc tgcgaaatgg atttaatccg    360

aggcgtcttg ctccggctcc tgctcctggc ttccagcctc ggacccggcg cggtgtcgct    420

ccgagcggcc atccgaaaac caggcaaggt agggcctcct cttgacatca agctgggcgc    480

attgaactgt acggctttca gcatccagtg gaaaatgcca aggcatcctg gaagtcccat    540

ccttgggtac actgtctttt actctgaggt tggcgcagat aaatccctgc aggagcagtt    600

gcacagcgtg cctctcagcc gggacatccc gaccacggag gaagtgattg gagatttgaa    660

accaggcact gaatatcgtg tgagcatagc agcttacagc caggctggca aagggcggct    720

gagctctcct cggcatgtca ccactttgtc ccaagattcc tgcctgcctc ctgcagctcc    780

ccagcagcca catgtcattg tggtttcgga ttctgaggtg gccctgtctt ggaaacctgg    840

agcgagtgaa ggaagcgccc ctattcagta ctattctgtg gaattcatca ggccagattt    900

cgacaagaag tggacctcaa tccatgagcg gatccagatg gactccatgg ttatcaaggg    960

cctcgatcca gataccaact accagtttgc cgtgagggca atgaattccc atggccccag   1020

cccccgcagc tggcccagtg acatcatccg gaccctctgc cctgaggagg cgggaagtgg   1080

ccgctatgga ccccgttata tcaccgacat gggagctggt gaggatgatg aaggatttga   1140

agacgactta gatttggata tttcctttga ggaggttaaa ccacttcctg ctaccaaagg   1200

agggaataag aaatttttgg tggaaagcaa gaagatgtct atatctaacc caaagaccat   1260

ttctaggctc atccccccta cctcagcatc tctccctgtg accacggtgg ctccccagcc   1320

cattcccata cagagaaagg ggaagaatgg tgtggccata atgtcaaggc tctttgacat   1380

gccttgtgat gaaactctct gctctgctga cagcttctgt gtcaatgact acacctgggg   1440

gggctcgcga tgccagtgca ccctgggcaa aggtggtgag agctgctcag aagatattgt   1500

tatccagtat cctcattcct tgggccttcg ggatggagcc ctcgtgttca gctataacct   1560

gggcagtggt gtggcatcca tcatggtgaa tggctccttc aacgatggtc ggtggcaccg   1620

agttaaggcc gttagggatg gccagtcagg aaagataacc gtggatgact atggagccag   1680

aacaggcaaa tccccaggca tgatgcggca gcttaacatc aatggagctc tgtatgtggg   1740

tggaatgaag gaaattgctc tgcacactaa caggcaatat atgagagggc tcgtgggctg   1800

tatctctcac ttcaccctgt ccaccgatta ccacatttcc ctcgtggaag atgccgtgga   1860

tgggaaaaac atcaacactt gtggagccaa gtaacaccag ctggccttgt ccaagggaca   1920

gagccttcta ttctgagaat cccaggggcc ctcagaccct gcctgatgct atatgcagag   1980

gcccagggac caggtgtgtt tcctctcacc aagaagaaag tacacactga tgagaaactg   2040

agaaccaaga caggcatccc tgggtggcct ttcctgctga cactccacga gctgacccag   2100

cagaattctc tgtgtaggaa gcatcggact ttgtccattg aatatgtagc ggctgccaga   2160

gatcacacat caatgcaaat tccagagcct gtctgctata gctcagtgac tgtgttgtga   2220

ttcatagtac attaaaaaga gagagagaga gaaagaatcc cacagggcac tattaaaata   2280

cttctctcct tccctgactc atgacactct tcctgacagc agaatgactg tgtgaccttg   2340

aacttcacat ttcccacatt ggcccttgga ttgttcggat taaccccttc cactcctcac   2400

tggctggttc actgtgttct gactagtcca taaaaataaa gatggaagga gatcaaacac   2460

agaatcataa tcataatgcg gcccccttcc ccagagctta cctcgaatgt gaaatcccta   2520

cttcttataa tgcagagtta aggagctgag cccccatgat tttgtagctg tacttttgta   2580

tgtgtatatt tttatagctg cagattgtcc acacagtata cttttggaag tttgggtgga   2640

tgactctgaa ttcttgcaca cctttcctaa aaatttctcc caagagagac ttgtttgggc   2700

cttttgtggt gtcagtggaa tggataggta acttgggtgg gcaacttggg gagctgacca   2760

ttctcttttg gtaaatgttg acggctcaag aggatgaata tgaagctttc caagataagc   2820

agattaaaag gaacatgtgt taccgaggt                                     2849


<210>  2707
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  2707

Met Asp Leu Ile Arg Gly Val Leu Leu Arg Leu Leu Leu Leu Ala Ser 
1               5                   10                  15


Ser Leu Gly Pro Gly Ala Val Ser Leu Arg Ala Ala Ile Arg Lys Pro 
            20                  25                  30


Gly Lys Val Gly Pro Pro Leu Asp Ile Lys Leu Gly Ala Leu Asn Cys 
        35                  40                  45


Thr Ala Phe Ser Ile Gln Trp Lys Met Pro Arg His Pro Gly Ser Pro 
    50                  55                  60


Ile Leu Gly Tyr Thr Val Phe Tyr Ser Glu Val Gly Ala Asp Lys Ser 
65                  70                  75                  80


Leu Gln Glu Gln Leu His Ser Val Pro Leu Ser Arg Asp Ile Pro Thr 
                85                  90                  95


Thr Glu Glu Val Ile Gly Asp Leu Lys Pro Gly Thr Glu Tyr Arg Val 
            100                 105                 110


Ser Ile Ala Ala Tyr Ser Gln Ala Gly Lys Gly Arg Leu Ser Ser Pro 
        115                 120                 125


Arg His Val Thr Thr Leu Ser Gln Asp Ser Cys Leu Pro Pro Ala Ala 
    130                 135                 140


Pro Gln Gln Pro His Val Ile Val Val Ser Asp Ser Glu Val Ala Leu 
145                 150                 155                 160


Ser Trp Lys Pro Gly Ala Ser Glu Gly Ser Ala Pro Ile Gln Tyr Tyr 
                165                 170                 175


Ser Val Glu Phe Ile Arg Pro Asp Phe Asp Lys Lys Trp Thr Ser Ile 
            180                 185                 190


His Glu Arg Ile Gln Met Asp Ser Met Val Ile Lys Gly Leu Asp Pro 
        195                 200                 205


Asp Thr Asn Tyr Gln Phe Ala Val Arg Ala Met Asn Ser His Gly Pro 
    210                 215                 220


Ser Pro Arg Ser Trp Pro Ser Asp Ile Ile Arg Thr Leu Cys Pro Glu 
225                 230                 235                 240


Glu Ala Gly Ser Gly Arg Tyr Gly Pro Arg Tyr Ile Thr Asp Met Gly 
                245                 250                 255


Ala Gly Glu Asp Asp Glu Gly Phe Glu Asp Asp Leu Asp Leu Asp Ile 
            260                 265                 270


Ser Phe Glu Glu Val Lys Pro Leu Pro Ala Thr Lys Gly Gly Asn Lys 
        275                 280                 285


Lys Phe Leu Val Glu Ser Lys Lys Met Ser Ile Ser Asn Pro Lys Thr 
    290                 295                 300


Ile Ser Arg Leu Ile Pro Pro Thr Ser Ala Ser Leu Pro Val Thr Thr 
305                 310                 315                 320


Val Ala Pro Gln Pro Ile Pro Ile Gln Arg Lys Gly Lys Asn Gly Val 
                325                 330                 335


Ala Ile Met Ser Arg Leu Phe Asp Met Pro Cys Asp Glu Thr Leu Cys 
            340                 345                 350


Ser Ala Asp Ser Phe Cys Val Asn Asp Tyr Thr Trp Gly Gly Ser Arg 
        355                 360                 365


Cys Gln Cys Thr Leu Gly Lys Gly Gly Glu Ser Cys Ser Glu Asp Ile 
    370                 375                 380


Val Ile Gln Tyr Pro His Ser Leu Gly Leu Arg Asp Gly Ala Leu Val 
385                 390                 395                 400


Phe Ser Tyr Asn Leu Gly Ser Gly Val Ala Ser Ile Met Val Asn Gly 
                405                 410                 415


Ser Phe Asn Asp Gly Arg Trp His Arg Val Lys Ala Val Arg Asp Gly 
            420                 425                 430


Gln Ser Gly Lys Ile Thr Val Asp Asp Tyr Gly Ala Arg Thr Gly Lys 
        435                 440                 445


Ser Pro Gly Met Met Arg Gln Leu Asn Ile Asn Gly Ala Leu Tyr Val 
    450                 455                 460


Gly Gly Met Lys Glu Ile Ala Leu His Thr Asn Arg Gln Tyr Met Arg 
465                 470                 475                 480


Gly Leu Val Gly Cys Ile Ser His Phe Thr Leu Ser Thr Asp Tyr His 
                485                 490                 495


Ile Ser Leu Val Glu Asp Ala Val Asp Gly Lys Asn Ile Asn Thr Cys 
            500                 505                 510


Gly Ala Lys 
        515


<210>  2708
<211>  2928
<212>  DNA
<213>  Homo sapiens

<400>  2708
agggcctgtc cctctcactt ccactcgatt gtaatttcat ccccgggccg gtcgagcctc     60

cctccctccc gcggccagcc cttccctccc agtcggcctc cttcgtcgcc cccgcccccg    120

cgaaaagccc tgcagcttgc agccggcttc actcgcgcac gccgacctcc cggctgcagt    180

cctacctctt ggaactaccc gtgtttccgg gcccagccct cgcagccccc cacctcctcg    240

ccccggcccg gggatccgtt ggggccgcgt cccccacgcg cccccggaga cgccctttcc    300

gtgtgcgccc gggacttggt gaaactttgc aggcgccggc tgcgaaatgg atttaatccg    360

aggcgtcttg ctccggctcc tgctcctggc ttccagcctc ggacccggcg cggtgtcgct    420

ccgagcggcc atccgaaaac caggcaaggt agggcctcct cttgacatca agctgggcgc    480

attgaactgt acggctttca gcatccagtg gaaaatgcca aggcatcctg gaagtcccat    540

ccttgggtac actgtctttt actctgaggt tggcgcagat aaatccctgc aggagcagtt    600

gcacagcgtg cctctcagcc gggacatccc gaccacggag gaagtgattg gagatttgaa    660

accaggcact gaatatcgtg tgagcatagc agcttacagc caggctggca aagggcggct    720

gagctctcct cggcatgtca ccactttgtc ccaagattcc tgcctgcctc ctgcagctcc    780

ccagcagcca catgtcattg tggtttcgga ttctgaggtg gccctgtctt ggaaacctgg    840

agcgagtgaa ggaagcgccc ctattcagta ctattctgtg gaattcatca ggccagattt    900

cgacaagaag tggacctcaa tccatgagcg gatccagatg gactccatgg ttatcaaggg    960

cctcgatcca gataccaact accagtttgc cgtgagggca atgaattccc atggccccag   1020

cccccgcagc tggcccagtg acatcatccg gaccctctgc cctgaggagg cgggaagtgg   1080

ccgctatgga ccccgttata tcaccgacat gggagctggt gaggatgatg aaggatttga   1140

agacgactta gatttggata tttcctttga ggaggttaaa ccacttcctg ctaccaaagg   1200

agggaataag aaatttttgg tggaaagcaa gaagatgtct atatctaacc caaagaccat   1260

ttctaggctc atccccccta cctcagcatc tctccctgtg accacggtgg ctccccagcc   1320

cattcccata cagagaaagg ggaagaatgg tgtggccata atgtcaaggc tctttgacat   1380

gccttgtgat gaaactctct gctctgctga cagcttctgt gtcaatgact acacctgggg   1440

gggctcgcga tgccagtgca ccctgggcaa aggtggtgag agctgctcag aagatattgt   1500

tatccagtat cctcattcct tgggccttcg ggatggagcc ctcgtgttca gctataacct   1560

gggcagtggt gtggcatcca tcatggtgaa tggctccttc aacgatggtc ggtggcaccg   1620

agttaaggcc gttagggatg gccagtcagg aaagataacc gtggatgact atggagccag   1680

aacaggcaaa tccccaggca tgatgcggca gcttaacatc aatggagctc tgtatgtggg   1740

tggaatgaag gaaattgctc tgcacactaa caggcaatat atgagagggc tcgtgggctg   1800

tatctctcac ttcaccctgt ccaccgatta ccacatttcc ctcgtggaag atgccgtgga   1860

tgggaaaaac atcaacactt gtggagccaa gtaacaccag ctggccttgt ccaagggaca   1920

gagccttcta ttctgagaat cccaggggcc ctcagaccct gcctgatgct atatgcagag   1980

gcccagggac caggtgtgtt tcctctcacc aagaagaaag tacacactga tgagaaactg   2040

agaaccaaga caggcatccc tgggtggcct ttcctgctga cactccacga gctgacccag   2100

cagaattctc tgtgtaggaa gcatcggact ttgtccattg aatatgtagc ggctgccaga   2160

gatcacacat caatgcaaat tccagagcct gtctgctata gctcagtgac tgtgttgtga   2220

ttcatagtac attaaaaaga gagagagaga gaaagaatcc cacagggcac tattaaaata   2280

cttctctcct tccctgactc atgacactct tcctgacagc agaatgactg tgtgaccttg   2340

aacttcacat ttcccacatt ggcccttgga ttgttcggat taaccccttc cactcctcac   2400

tggctggttc actgtgttct gactagtcca taaaaataaa gatggaagga gatcaaacac   2460

agaatcataa tcataatgcg gcccccttcc ccagagctta cctcgaatgt gaaatcccta   2520

cttcttataa tgcagagtta aggagctgag cccccatgat tttgtagctg tacttttgta   2580

tgtgtatatt tttatagctg cagattgtcc acacagtata cttttggaag tttgggtgga   2640

tgactctgaa ttcttgcaca cctttcctaa aaatttctcc caagagagac ttgtttgggc   2700

cttttgtggt gtcagtggaa tggataggta acttgggtgg gcaacttggg gagctgacca   2760

ttctcttttg gtaaatgttg acggctcaag aggatgaata tgaagctttc caagataagc   2820

agattaaaag gaacatgtgt taccgaggta ggtcactgtc atttttgttt taagagttgg   2880

ggggagtatc tatagtaaac ttgaataaag gggacaaagc tagaactt                2928


<210>  2709
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  2709

Met Asp Leu Ile Arg Gly Val Leu Leu Arg Leu Leu Leu Leu Ala Ser 
1               5                   10                  15


Ser Leu Gly Pro Gly Ala Val Ser Leu Arg Ala Ala Ile Arg Lys Pro 
            20                  25                  30


Gly Lys Val Gly Pro Pro Leu Asp Ile Lys Leu Gly Ala Leu Asn Cys 
        35                  40                  45


Thr Ala Phe Ser Ile Gln Trp Lys Met Pro Arg His Pro Gly Ser Pro 
    50                  55                  60


Ile Leu Gly Tyr Thr Val Phe Tyr Ser Glu Val Gly Ala Asp Lys Ser 
65                  70                  75                  80


Leu Gln Glu Gln Leu His Ser Val Pro Leu Ser Arg Asp Ile Pro Thr 
                85                  90                  95


Thr Glu Glu Val Ile Gly Asp Leu Lys Pro Gly Thr Glu Tyr Arg Val 
            100                 105                 110


Ser Ile Ala Ala Tyr Ser Gln Ala Gly Lys Gly Arg Leu Ser Ser Pro 
        115                 120                 125


Arg His Val Thr Thr Leu Ser Gln Asp Ser Cys Leu Pro Pro Ala Ala 
    130                 135                 140


Pro Gln Gln Pro His Val Ile Val Val Ser Asp Ser Glu Val Ala Leu 
145                 150                 155                 160


Ser Trp Lys Pro Gly Ala Ser Glu Gly Ser Ala Pro Ile Gln Tyr Tyr 
                165                 170                 175


Ser Val Glu Phe Ile Arg Pro Asp Phe Asp Lys Lys Trp Thr Ser Ile 
            180                 185                 190


His Glu Arg Ile Gln Met Asp Ser Met Val Ile Lys Gly Leu Asp Pro 
        195                 200                 205


Asp Thr Asn Tyr Gln Phe Ala Val Arg Ala Met Asn Ser His Gly Pro 
    210                 215                 220


Ser Pro Arg Ser Trp Pro Ser Asp Ile Ile Arg Thr Leu Cys Pro Glu 
225                 230                 235                 240


Glu Ala Gly Ser Gly Arg Tyr Gly Pro Arg Tyr Ile Thr Asp Met Gly 
                245                 250                 255


Ala Gly Glu Asp Asp Glu Gly Phe Glu Asp Asp Leu Asp Leu Asp Ile 
            260                 265                 270


Ser Phe Glu Glu Val Lys Pro Leu Pro Ala Thr Lys Gly Gly Asn Lys 
        275                 280                 285


Lys Phe Leu Val Glu Ser Lys Lys Met Ser Ile Ser Asn Pro Lys Thr 
    290                 295                 300


Ile Ser Arg Leu Ile Pro Pro Thr Ser Ala Ser Leu Pro Val Thr Thr 
305                 310                 315                 320


Val Ala Pro Gln Pro Ile Pro Ile Gln Arg Lys Gly Lys Asn Gly Val 
                325                 330                 335


Ala Ile Met Ser Arg Leu Phe Asp Met Pro Cys Asp Glu Thr Leu Cys 
            340                 345                 350


Ser Ala Asp Ser Phe Cys Val Asn Asp Tyr Thr Trp Gly Gly Ser Arg 
        355                 360                 365


Cys Gln Cys Thr Leu Gly Lys Gly Gly Glu Ser Cys Ser Glu Asp Ile 
    370                 375                 380


Val Ile Gln Tyr Pro His Ser Leu Gly Leu Arg Asp Gly Ala Leu Val 
385                 390                 395                 400


Phe Ser Tyr Asn Leu Gly Ser Gly Val Ala Ser Ile Met Val Asn Gly 
                405                 410                 415


Ser Phe Asn Asp Gly Arg Trp His Arg Val Lys Ala Val Arg Asp Gly 
            420                 425                 430


Gln Ser Gly Lys Ile Thr Val Asp Asp Tyr Gly Ala Arg Thr Gly Lys 
        435                 440                 445


Ser Pro Gly Met Met Arg Gln Leu Asn Ile Asn Gly Ala Leu Tyr Val 
    450                 455                 460


Gly Gly Met Lys Glu Ile Ala Leu His Thr Asn Arg Gln Tyr Met Arg 
465                 470                 475                 480


Gly Leu Val Gly Cys Ile Ser His Phe Thr Leu Ser Thr Asp Tyr His 
                485                 490                 495


Ile Ser Leu Val Glu Asp Ala Val Asp Gly Lys Asn Ile Asn Thr Cys 
            500                 505                 510


Gly Ala Lys 
        515


<210>  2710
<211>  3387
<212>  DNA
<213>  Homo sapiens

<400>  2710
agggcctgtc cctctcactt ccactcgatt gtaatttcat ccccgggccg gtcgagcctc     60

cctccctccc gcggccagcc cttccctccc agtcggcctc cttcgtcgcc cccgcccccg    120

cgaaaagccc tgcagcttgc agccggcttc actcgcgcac gccgacctcc cggctgcagt    180

cctacctctt ggaactaccc gtgtttccgg gcccagccct cgcagccccc cacctcctcg    240

ccccggcccg gggatccgtt ggggccgcgt cccccacgcg cccccggaga cgccctttcc    300

gtgtgcgccc gggacttggt gaaactttgc aggcgccggc tgcgaaatgg atttaatccg    360

aggcgtcttg ctccggctcc tgctcctggc ttccagcctc ggacccggcg cggtgtcgct    420

ccgagcggcc atccgaaaac caggcaaggt agggcctcct cttgacatca agctgggcgc    480

attgaactgt acggctttca gcatccagtg gaaaatgcca aggcatcctg gaagtcccat    540

ccttgggtac actgtctttt actctgaggt tggcgcagat aaatccctgc aggagcagtt    600

gcacagcgtg cctctcagcc gggacatccc gaccacggag gaagtgattg gagatttgaa    660

accaggcact gaatatcgtg tgagcatagc agcttacagc caggctggca aagggcggct    720

gagctctcct cggcatgtca ccactttgtc ccaagattcc tgcctgcctc ctgcagctcc    780

ccagcagcca catgtcattg tggtttcgga ttctgaggtg gccctgtctt ggaaacctgg    840

agcgagtgaa ggaagcgccc ctattcagta ctattctgtg gaattcatca ggccagattt    900

cgacaagaag tggacctcaa tccatgagcg gatccagatg gactccatgg ttatcaaggg    960

cctcgatcca gataccaact accagtttgc cgtgagggca atgaattccc atggccccag   1020

cccccgcagc tggcccagtg acatcatccg gaccctctgc cctgaggagg cgggaagtgg   1080

ccgctatgga ccccgttata tcaccgacat gggagctggt gaggatgatg aaggatttga   1140

agacgactta gatttggata tttcctttga ggaggttaaa ccacttcctg ctaccaaagg   1200

agggaataag aaatttttgg tggaaagcaa gaagatgtct atatctaacc caaagaccat   1260

ttctaggctc atccccccta cctcagcatc tctccctgtg accacggtgg ctccccagcc   1320

cattcccata cagagaaagg ggaagaatgg tgtggccata atgtcaaggc tctttgacat   1380

gccttgtgat gaaactctct gctctgctga cagcttctgt gtcaatgact acacctgggg   1440

gggctcgcga tgccagtgca ccctgggcaa aggtggtgag agctgctcag aagatattgt   1500

tatccagtat cctcattcct tgggccttcg ggatggagcc ctcgtgttca gctataacct   1560

gggcagtggt gtggcatcca tcatggtgaa tggctccttc aacgatggtc ggtggcaccg   1620

agttaaggcc gttagggatg gccagtcagg aaagataacc gtggatgact atggagccag   1680

aacaggcaaa tccccaggca tgatgcggca gcttaacatc aatggagctc tgtatgtggg   1740

tggaatgaag gaaattgctc tgcacactaa caggcaatat atgagagggc tcgtgggctg   1800

tatctctcac ttcaccctgt ccaccgatta ccacatttcc ctcgtggaag atgccgtgga   1860

tgggaaaaac atcaacactt gtggagccaa gtaacaccag ctggccttgt ccaagggaca   1920

gagccttcta ttctgagaat cccaggggcc ctcagaccct gcctgatgct atatgcagag   1980

gcccagggac caggtgtgtt tcctctcacc aagaagaaag tacacactga tgagaaactg   2040

agaaccaaga caggcatccc tgggtggcct ttcctgctga cactccacga gctgacccag   2100

cagaattctc tgtgtaggaa gcatcggact ttgtccattg aatatgtagc ggctgccaga   2160

gatcacacat caatgcaaat tccagagcct gtctgctata gctcagtgac tgtgttgtga   2220

ttcatagtac attaaaaaga gagagagaga gaaagaatcc cacagggcac tattaaaata   2280

cttctctcct tccctgactc atgacactct tcctgacagc agaatgactg tgtgaccttg   2340

aacttcacat ttcccacatt ggcccttgga ttgttcggat taaccccttc cactcctcac   2400

tggctggttc actgtgttct gactagtcca taaaaataaa gatggaagga gatcaaacac   2460

agaatcataa tcataatgcg gcccccttcc ccagagctta cctcgaatgt gaaatcccta   2520

cttcttataa tgcagagtta aggagctgag cccccatgat tttgtagctg tacttttgta   2580

tgtgtatatt tttatagctg cagattgtcc acacagtata cttttggaag tttgggtgga   2640

tgactctgaa ttcttgcaca cctttcctaa aaatttctcc caagagagac ttgtttgggc   2700

cttttgtggt gtcagtggaa tggataggta acttgggtgg gcaacttggg gagctgacca   2760

ttctcttttg gtaaatgttg acggctcaag aggatgaata tgaagctttc caagataagc   2820

agattaaaag gaacatgtgt taccgaggta ggtcactgtc atttttgttt taagagttgg   2880

ggggagtatc tatagtaaac ttgaataaag gggacaaagc tagaacttat tcattcattc   2940

attcacttat ggagttgtta ctgattttgc ggaggtcagg ttcataccaa tggacactaa   3000

tacaatcagt gttcccaagg ctgtgcaggg gtggggggac atgctgtcag gatggtctga   3060

gcatctgggt gagaaccaga gaaacaggac ttcttccttc tgtaccatga gctgtgtccc   3120

tttactatgc aagcacatga ccccagagac agctggttca ctggcagatc cccatgatgg   3180

acttactaag ggaaaggtga gatgaacact gcccccaagg agggggtgaa atatgatcta   3240

acttatgcaa gagcctataa ttagtcccag tctcgactct acatttgttt gtgcagcatt   3300

cattcagcaa agacttttgg ggtttgtgca aggcacagtt ttaagcacat aatgtaattc   3360

taaaagatga ataaactaga gaggttc                                       3387


<210>  2711
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  2711

Met Asp Leu Ile Arg Gly Val Leu Leu Arg Leu Leu Leu Leu Ala Ser 
1               5                   10                  15


Ser Leu Gly Pro Gly Ala Val Ser Leu Arg Ala Ala Ile Arg Lys Pro 
            20                  25                  30


Gly Lys Val Gly Pro Pro Leu Asp Ile Lys Leu Gly Ala Leu Asn Cys 
        35                  40                  45


Thr Ala Phe Ser Ile Gln Trp Lys Met Pro Arg His Pro Gly Ser Pro 
    50                  55                  60


Ile Leu Gly Tyr Thr Val Phe Tyr Ser Glu Val Gly Ala Asp Lys Ser 
65                  70                  75                  80


Leu Gln Glu Gln Leu His Ser Val Pro Leu Ser Arg Asp Ile Pro Thr 
                85                  90                  95


Thr Glu Glu Val Ile Gly Asp Leu Lys Pro Gly Thr Glu Tyr Arg Val 
            100                 105                 110


Ser Ile Ala Ala Tyr Ser Gln Ala Gly Lys Gly Arg Leu Ser Ser Pro 
        115                 120                 125


Arg His Val Thr Thr Leu Ser Gln Asp Ser Cys Leu Pro Pro Ala Ala 
    130                 135                 140


Pro Gln Gln Pro His Val Ile Val Val Ser Asp Ser Glu Val Ala Leu 
145                 150                 155                 160


Ser Trp Lys Pro Gly Ala Ser Glu Gly Ser Ala Pro Ile Gln Tyr Tyr 
                165                 170                 175


Ser Val Glu Phe Ile Arg Pro Asp Phe Asp Lys Lys Trp Thr Ser Ile 
            180                 185                 190


His Glu Arg Ile Gln Met Asp Ser Met Val Ile Lys Gly Leu Asp Pro 
        195                 200                 205


Asp Thr Asn Tyr Gln Phe Ala Val Arg Ala Met Asn Ser His Gly Pro 
    210                 215                 220


Ser Pro Arg Ser Trp Pro Ser Asp Ile Ile Arg Thr Leu Cys Pro Glu 
225                 230                 235                 240


Glu Ala Gly Ser Gly Arg Tyr Gly Pro Arg Tyr Ile Thr Asp Met Gly 
                245                 250                 255


Ala Gly Glu Asp Asp Glu Gly Phe Glu Asp Asp Leu Asp Leu Asp Ile 
            260                 265                 270


Ser Phe Glu Glu Val Lys Pro Leu Pro Ala Thr Lys Gly Gly Asn Lys 
        275                 280                 285


Lys Phe Leu Val Glu Ser Lys Lys Met Ser Ile Ser Asn Pro Lys Thr 
    290                 295                 300


Ile Ser Arg Leu Ile Pro Pro Thr Ser Ala Ser Leu Pro Val Thr Thr 
305                 310                 315                 320


Val Ala Pro Gln Pro Ile Pro Ile Gln Arg Lys Gly Lys Asn Gly Val 
                325                 330                 335


Ala Ile Met Ser Arg Leu Phe Asp Met Pro Cys Asp Glu Thr Leu Cys 
            340                 345                 350


Ser Ala Asp Ser Phe Cys Val Asn Asp Tyr Thr Trp Gly Gly Ser Arg 
        355                 360                 365


Cys Gln Cys Thr Leu Gly Lys Gly Gly Glu Ser Cys Ser Glu Asp Ile 
    370                 375                 380


Val Ile Gln Tyr Pro His Ser Leu Gly Leu Arg Asp Gly Ala Leu Val 
385                 390                 395                 400


Phe Ser Tyr Asn Leu Gly Ser Gly Val Ala Ser Ile Met Val Asn Gly 
                405                 410                 415


Ser Phe Asn Asp Gly Arg Trp His Arg Val Lys Ala Val Arg Asp Gly 
            420                 425                 430


Gln Ser Gly Lys Ile Thr Val Asp Asp Tyr Gly Ala Arg Thr Gly Lys 
        435                 440                 445


Ser Pro Gly Met Met Arg Gln Leu Asn Ile Asn Gly Ala Leu Tyr Val 
    450                 455                 460


Gly Gly Met Lys Glu Ile Ala Leu His Thr Asn Arg Gln Tyr Met Arg 
465                 470                 475                 480


Gly Leu Val Gly Cys Ile Ser His Phe Thr Leu Ser Thr Asp Tyr His 
                485                 490                 495


Ile Ser Leu Val Glu Asp Ala Val Asp Gly Lys Asn Ile Asn Thr Cys 
            500                 505                 510


Gly Ala Lys 
        515


<210>  2712
<211>  5205
<212>  DNA
<213>  Homo sapiens

<400>  2712
ctcccgaagg tccagccctt acccgccttc ctaccacctt aggggatttg gcccggagaa     60

cgagatcacc ctctcaatga aaggcagatg tccctttaag gtttgcttct acagcccgtg    120

gactttagcc taaacacgga cccgcgaagc tggctttatt tgtccatgtc tcggacagag    180

cctgggaagc tgccagtgag atttcagaga ccaagagcgc gaaggggcgg gcgatgtggc    240

aatccgtctg ggatgtgaaa agcgtggagc gcatttagag gaattcgacg aaaacacagg    300

aaatcactcc tctcccgctc ctgggcgccg ctgccactgg ggcagaggac tgggaaccgc    360

ggcagcggga taagtggccc agccagagag cgcagctccc gcgcccggtc ctgccctgcg    420

aaccagcgcg gccccctggc gctgaggctg ctccggccat ggcccctcgg ccccgcgccc    480

gcccaggggt cgctgtcgcc tgctgctggc tcctcactgt tgttctacgc tgctgcgtat    540

cattcaatgt tgatgtgaaa aattcaatga ctttcagcgg cccggtggaa gacatgtttg    600

gatatactgt tcaacaatat gaaaatgaag aaggaaaatg ggtgcttatt ggttctccgt    660

tagttggcca acccaaaaac agaactggag atgtctataa gtgtccagtt gggagaggtg    720

aatcattacc ttgtgtaaag ttggatctac cagttaatac atcaattccc aatgtcacag    780

aagtaaagga gaacatgaca tttggatcaa ctttagtcac caacccaaat ggaggatttc    840

tggcttgtgg gcccttatat gcctatagat gtggacattt gcattacaca actggaatct    900

gttctgacgt cagccccaca tttcaagtcg tgaattccat tgcccctgta caagaatgca    960

gcactcaact ggacatagtc atagtgctgg atggttccaa cagtatttac ccatgggaca   1020

gtgttacagc ttttttaaat gaccttcttg aaagaatgga tattggtcct aaacagacac   1080

aggttggaat tgtacagtat ggagaaaacg tgacccatga gttcaacctc aataagtatt   1140

cttccaccga agaggtactt gttgcagcaa agaaaatagt ccagagaggt ggccgccaga   1200

ctatgacagc tcttggaata gacacagcaa gaaaggaggc attcacggaa gcccggggtg   1260

cccgaagagg agttaaaaaa gtcatggtta ttgtgacaga tggagagtct catgacaatc   1320

atcgactgaa gaaggtcatc caagactgtg aagatgaaaa cattcaacgg ttttccatag   1380

ctattcttgg cagctataac cgaggaaatt taagcactga aaaatttgtg gaggaaataa   1440

aatcaattgc aagtgaaccc actgaaaagc atttcttcaa tgtctctgat gaattggctc   1500

tagtcaccat tgttaaaact ctgggagaaa gaatatttgc cctggaagcc acagctgacc   1560

agtcagcagc ttcatttgaa atggaaatgt ctcagactgg cttcagtgct cattattcac   1620

aggactgggt catgcttgga gcagtaggag cctatgattg gaatggaaca gttgtcatgc   1680

agaaggctag tcaaatcata atccctcgaa acacaacctt taatgttgag tctaccaaaa   1740

agaatgaacc gcttgcttct tatttaggtt acactgtaaa ctctgctact gcttcttctg   1800

gagatgtgct ctatattgct ggacagcctc ggtacaatca tacaggccag gtcattatct   1860

acaggatgga agatggaaac atcaaaattc tccagacgct cagtggagaa cagattggtt   1920

cctactttgg cagtatttta acaacaactg acattgacaa ggattctaat actgacattc   1980

ttctagtcgg agcccctatg tacatgggaa cagagaagga ggagcaagga aaagtgtatg   2040

tgtatgctct caatcagaca aggtttgaat atcaaatgag cctggaacct attaagcaga   2100

cgtgctgttc atctcggcag cacaattcat gcacaacaga aaacaaaaat gagccatgcg   2160

gggctcgttt tggaactgca attgctgctg taaaagacct caatcttgat ggatttaatg   2220

acatcgtgat aggagctccg ctggaagatg atcacggggg agctgtgtac atttatcatg   2280

gaagtggcaa gactataagg aaagagtatg cacaacgtat tccatcaggt ggggatggta   2340

agacactgaa attttttggc cagtctatcc acggagaaat ggatttaaat ggtgacggtc   2400

tgacagatgt gactattggg ggccttggtg gtgctgccct cttctggtcc cgagatgtgg   2460

ccgtagttaa agtgaccatg aattttgagc caaataaagt gaatattcaa aagaaaaact   2520

gccatatgga gggaaaggaa acagtatgca taaatgctac agtgtgtttt gatgtgaaat   2580

taaagtctaa agaagacacg atttatgaag ctgatttgca gtaccgtgtc accctagatt   2640

cactaagaca aatatcacga agttttttct ctggaactca agagagaaag gttcaaagga   2700

acatcacagt tcgaaaatca gaatgcacta agcactcctt ctacatgttg gcaagacaag   2760

catgactttc aggactctgt gagaataacg ttggacttta atcttaccga tccagaaaat   2820

gggcctgttc ttgatgattc tctaccaaac tcagtacatg aatatattcc ctttgccaaa   2880

gattgtggaa ataaggaaaa atgtatctca gacctcagcc tgcatgtcgc caccactgaa   2940

aaggacctgc tgattgtccg atcccagaat gataagttca acgttagcct cacagtcaaa   3000

aatacaaagg acagtgccta taacaccagg acaatagtgc attattctcc aaatctagtt   3060

ttttcaggaa ttgaggctat ccaaaaagac agttgtgaat ctaatcataa tatcacatgt   3120

aaagttggat atcccttcct gagaagagga gagatggtaa ctttcaaaat attgtttcag   3180

tttaacacat cctatctcat ggaaaatgtg accatttatt taagtgcaac aagtgacagc   3240

gaagaacctc ctgaaaccct ttctgataat gtagtaaaca tttctatccc ggtaaaatat   3300

gaagttggac tacagtttta cagctctgca agtgaatacc acatttcaat tgctgccaat   3360

gagacagtcc ctgaagttat taattctact gaggacattg gaaatgaaat taatatcttc   3420

tacttgatta gaaaaagtgg atcttttcca atgccagagc ttaagctgtc aatttcattc   3480

cccaatatga catcaaatgg ttaccctgtg ctgtacccaa ctggattgtc atcttctgag   3540

aatgcaaact gcagacccca tatctttgag gatcctttca gtatcaactc tggaaagaaa   3600

atgactacat caactgacca tctcaaacga ggcacaattc tggactgcaa tacatgtaaa   3660

tttgctacca tcacatgtaa tctcacttct tctgacatca gccaagtcaa tgtttcgctt   3720

atcttgtgga aaccaacttt tataaaatca tatttttcca gcttaaatct tactataagg   3780

ggagaacttc ggagtgaaaa tgcatctctg gttttaagta gcagcaatca aaaaagagag   3840

cttgctattc aaatatccaa agatgggcta ccgggcagag tgccattatg ggtcatcctg   3900

ctgagtgctt ttgccggatt gttgctgtta atgctgctca ttttagcact gtggaagatt   3960

ggattcttca aaagaccact gaaaaagaaa atggagaaat gaaatatttt atgaaagaaa   4020

ataataacaa ttattcaata atctatcctc aggtttgcct caaatatgtg acaagaaatg   4080

tataattcat gacatagtca tgtaactatg taatccatca gggattcatt acttggaaaa   4140

tgacaggtca tgcattatcc aaaaacaata ccaaaaagac atattttata aaatgacaaa   4200

aaatatttta cataattact catttttgtt gagtaagcaa aattacaaag tgtttttaaa   4260

aaaacctgta caaatatgtt tatgtattaa atcaccatcc aaaatattta aggaatatat   4320

aaaaagattt ttatgatcat agaaacatct attttcaaaa caatataaat taagcttttc   4380

cccttgattc ctgttggata tccatgttca gcatgacagt cagcactcgt aaatgccaag   4440

aaaagaatta cctgaaaaag atcatttctc cctattcaaa tgagaatatt ttcccttggt   4500

agaatccata tacaatatgg attgaaaatt aagtcaccaa gaatacattt agcatctttg   4560

tgttgggttc tatacctaaa aattttccct ccctgcccaa ggtgattgga aagtactgca   4620

attgagctaa aattttatct aggatggaaa atcaggatag actcgtttaa aaacaagtat   4680

attaaatggg ttaaattaag cttttacaga acatgcttaa ttttgatatt gagctctaaa   4740

tgcaaaactc ttttatactg aaaaaacact taaagtagtt ttgtgtggca tcacagtgat   4800

ttgtcatgaa aagccatata tgggggacat gctaaaatgg cttctgaatg aaatacgaca   4860

gcagagaaag atgccactga aatgctgaaa ttatctttgc tgagcagctt ttgaatgcta   4920

agggttccag tatgtgaccc aaagaaagag ttgtctcaac tccttggtac agggttcatt   4980

caaaccccca agctgtgaga gtgtgtttat ttttaatttt ttaaaaggta tttaatttcc   5040

aaccacactt cttatttttt tgaaaagaca attttccatt tcagtattac attttaccaa   5100

gaagtcactg ctttttaggt gtgttgcatc aatatttaaa taaaatccca gaaatgtatt   5160

ttaaagaatt tcaggtttga aaactcaaac caacaggaag atatc                   5205


<210>  2713
<211>  768
<212>  PRT
<213>  Homo sapiens

<400>  2713

Met Ala Pro Arg Pro Arg Ala Arg Pro Gly Val Ala Val Ala Cys Cys 
1               5                   10                  15


Trp Leu Leu Thr Val Val Leu Arg Cys Cys Val Ser Phe Asn Val Asp 
            20                  25                  30


Val Lys Asn Ser Met Thr Phe Ser Gly Pro Val Glu Asp Met Phe Gly 
        35                  40                  45


Tyr Thr Val Gln Gln Tyr Glu Asn Glu Glu Gly Lys Trp Val Leu Ile 
    50                  55                  60


Gly Ser Pro Leu Val Gly Gln Pro Lys Asn Arg Thr Gly Asp Val Tyr 
65                  70                  75                  80


Lys Cys Pro Val Gly Arg Gly Glu Ser Leu Pro Cys Val Lys Leu Asp 
                85                  90                  95


Leu Pro Val Asn Thr Ser Ile Pro Asn Val Thr Glu Val Lys Glu Asn 
            100                 105                 110


Met Thr Phe Gly Ser Thr Leu Val Thr Asn Pro Asn Gly Gly Phe Leu 
        115                 120                 125


Ala Cys Gly Pro Leu Tyr Ala Tyr Arg Cys Gly His Leu His Tyr Thr 
    130                 135                 140


Thr Gly Ile Cys Ser Asp Val Ser Pro Thr Phe Gln Val Val Asn Ser 
145                 150                 155                 160


Ile Ala Pro Val Gln Glu Cys Ser Thr Gln Leu Asp Ile Val Ile Val 
                165                 170                 175


Leu Asp Gly Ser Asn Ser Ile Tyr Pro Trp Asp Ser Val Thr Ala Phe 
            180                 185                 190


Leu Asn Asp Leu Leu Glu Arg Met Asp Ile Gly Pro Lys Gln Thr Gln 
        195                 200                 205


Val Gly Ile Val Gln Tyr Gly Glu Asn Val Thr His Glu Phe Asn Leu 
    210                 215                 220


Asn Lys Tyr Ser Ser Thr Glu Glu Val Leu Val Ala Ala Lys Lys Ile 
225                 230                 235                 240


Val Gln Arg Gly Gly Arg Gln Thr Met Thr Ala Leu Gly Ile Asp Thr 
                245                 250                 255


Ala Arg Lys Glu Ala Phe Thr Glu Ala Arg Gly Ala Arg Arg Gly Val 
            260                 265                 270


Lys Lys Val Met Val Ile Val Thr Asp Gly Glu Ser His Asp Asn His 
        275                 280                 285


Arg Leu Lys Lys Val Ile Gln Asp Cys Glu Asp Glu Asn Ile Gln Arg 
    290                 295                 300


Phe Ser Ile Ala Ile Leu Gly Ser Tyr Asn Arg Gly Asn Leu Ser Thr 
305                 310                 315                 320


Glu Lys Phe Val Glu Glu Ile Lys Ser Ile Ala Ser Glu Pro Thr Glu 
                325                 330                 335


Lys His Phe Phe Asn Val Ser Asp Glu Leu Ala Leu Val Thr Ile Val 
            340                 345                 350


Lys Thr Leu Gly Glu Arg Ile Phe Ala Leu Glu Ala Thr Ala Asp Gln 
        355                 360                 365


Ser Ala Ala Ser Phe Glu Met Glu Met Ser Gln Thr Gly Phe Ser Ala 
    370                 375                 380


His Tyr Ser Gln Asp Trp Val Met Leu Gly Ala Val Gly Ala Tyr Asp 
385                 390                 395                 400


Trp Asn Gly Thr Val Val Met Gln Lys Ala Ser Gln Ile Ile Ile Pro 
                405                 410                 415


Arg Asn Thr Thr Phe Asn Val Glu Ser Thr Lys Lys Asn Glu Pro Leu 
            420                 425                 430


Ala Ser Tyr Leu Gly Tyr Thr Val Asn Ser Ala Thr Ala Ser Ser Gly 
        435                 440                 445


Asp Val Leu Tyr Ile Ala Gly Gln Pro Arg Tyr Asn His Thr Gly Gln 
    450                 455                 460


Val Ile Ile Tyr Arg Met Glu Asp Gly Asn Ile Lys Ile Leu Gln Thr 
465                 470                 475                 480


Leu Ser Gly Glu Gln Ile Gly Ser Tyr Phe Gly Ser Ile Leu Thr Thr 
                485                 490                 495


Thr Asp Ile Asp Lys Asp Ser Asn Thr Asp Ile Leu Leu Val Gly Ala 
            500                 505                 510


Pro Met Tyr Met Gly Thr Glu Lys Glu Glu Gln Gly Lys Val Tyr Val 
        515                 520                 525


Tyr Ala Leu Asn Gln Thr Arg Phe Glu Tyr Gln Met Ser Leu Glu Pro 
    530                 535                 540


Ile Lys Gln Thr Cys Cys Ser Ser Arg Gln His Asn Ser Cys Thr Thr 
545                 550                 555                 560


Glu Asn Lys Asn Glu Pro Cys Gly Ala Arg Phe Gly Thr Ala Ile Ala 
                565                 570                 575


Ala Val Lys Asp Leu Asn Leu Asp Gly Phe Asn Asp Ile Val Ile Gly 
            580                 585                 590


Ala Pro Leu Glu Asp Asp His Gly Gly Ala Val Tyr Ile Tyr His Gly 
        595                 600                 605


Ser Gly Lys Thr Ile Arg Lys Glu Tyr Ala Gln Arg Ile Pro Ser Gly 
    610                 615                 620


Gly Asp Gly Lys Thr Leu Lys Phe Phe Gly Gln Ser Ile His Gly Glu 
625                 630                 635                 640


Met Asp Leu Asn Gly Asp Gly Leu Thr Asp Val Thr Ile Gly Gly Leu 
                645                 650                 655


Gly Gly Ala Ala Leu Phe Trp Ser Arg Asp Val Ala Val Val Lys Val 
            660                 665                 670


Thr Met Asn Phe Glu Pro Asn Lys Val Asn Ile Gln Lys Lys Asn Cys 
        675                 680                 685


His Met Glu Gly Lys Glu Thr Val Cys Ile Asn Ala Thr Val Cys Phe 
    690                 695                 700


Asp Val Lys Leu Lys Ser Lys Glu Asp Thr Ile Tyr Glu Ala Asp Leu 
705                 710                 715                 720


Gln Tyr Arg Val Thr Leu Asp Ser Leu Arg Gln Ile Ser Arg Ser Phe 
                725                 730                 735


Phe Ser Gly Thr Gln Glu Arg Lys Val Gln Arg Asn Ile Thr Val Arg 
            740                 745                 750


Lys Ser Glu Cys Thr Lys His Ser Phe Tyr Met Leu Ala Arg Gln Ala 
        755                 760                 765


<210>  2714
<211>  8044
<212>  DNA
<213>  Homo sapiens

<400>  2714
ctcccgaagg tccagccctt acccgccttc ctaccacctt aggggatttg gcccggagaa     60

cgagatcacc ctctcaatga aaggcagatg tccctttaag gtttgcttct acagcccgtg    120

gactttagcc taaacacgga cccgcgaagc tggctttatt tgtccatgtc tcggacagag    180

cctgggaagc tgccagtgag atttcagaga ccaagagcgc gaaggggcgg gcgatgtggc    240

aatccgtctg ggatgtgaaa agcgtggagc gcatttagag gaattcgacg aaaacacagg    300

aaatcactcc tctcccgctc ctgggcgccg ctgccactgg ggcagaggac tgggaaccgc    360

ggcagcggga taagtggccc agccagagag cgcagctccc gcgcccggtc ctgccctgcg    420

aaccagcgcg gccccctggc gctgaggctg ctccggccat ggcccctcgg ccccgcgccc    480

gcccaggggt cgctgtcgcc tgctgctggc tcctcactgt tgttctacgc tgctgcgtat    540

cattcaatgt tgatgtgaaa aattcaatga ctttcagcgg cccggtggaa gacatgtttg    600

gatatactgt tcaacaatat gaaaatgaag aaggaaaatg ggtgcttatt ggttctccgt    660

tagttggcca acccaaaaac agaactggag atgtctataa gtgtccagtt gggagaggtg    720

aatcattacc ttgtgtaaag ttggatctac cagttaatac atcaattccc aatgtcacag    780

aagtaaagga gaacatgaca tttggatcaa ctttagtcac caacccaaat ggaggatttc    840

tggcttgtgg gcccttatat gcctatagat gtggacattt gcattacaca actggaatct    900

gttctgacgt cagccccaca tttcaagtcg tgaattccat tgcccctgta caagaatgca    960

gcactcaact ggacatagtc atagtgctgg atggttccaa cagtatttac ccatgggaca   1020

gtgttacagc ttttttaaat gaccttcttg aaagaatgga tattggtcct aaacagacac   1080

aggttggaat tgtacagtat ggagaaaacg tgacccatga gttcaacctc aataagtatt   1140

cttccaccga agaggtactt gttgcagcaa agaaaatagt ccagagaggt ggccgccaga   1200

ctatgacagc tcttggaata gacacagcaa gaaaggaggc attcacggaa gcccggggtg   1260

cccgaagagg agttaaaaaa gtcatggtta ttgtgacaga tggagagtct catgacaatc   1320

atcgactgaa gaaggtcatc caagactgtg aagatgaaaa cattcaacgg ttttccatag   1380

ctattcttgg cagctataac cgaggaaatt taagcactga aaaatttgtg gaggaaataa   1440

aatcaattgc aagtgaaccc actgaaaagc atttcttcaa tgtctctgat gaattggctc   1500

tagtcaccat tgttaaaact ctgggagaaa gaatatttgc cctggaagcc acagctgacc   1560

agtcagcagc ttcatttgaa atggaaatgt ctcagactgg cttcagtgct cattattcac   1620

aggactgggt catgcttgga gcagtaggag cctatgattg gaatggaaca gttgtcatgc   1680

agaaggctag tcaaatcata atccctcgaa acacaacctt taatgttgag tctaccaaaa   1740

agaatgaacc gcttgcttct tatttaggtt acactgtaaa ctctgctact gcttcttctg   1800

gagatgtgct ctatattgct ggacagcctc ggtacaatca tacaggccag gtcattatct   1860

acaggatgga agatggaaac atcaaaattc tccagacgct cagtggagaa cagattggtt   1920

cctactttgg cagtatttta acaacaactg acattgacaa ggattctaat actgacattc   1980

ttctagtcgg agcccctatg tacatgggaa cagagaagga ggagcaagga aaagtgtatg   2040

tgtatgctct caatcagaca aggtttgaat atcaaatgag cctggaacct attaagcaga   2100

cgtgctgttc atctcggcag cacaattcat gcacaacaga aaacaaaaat gagccatgcg   2160

gggctcgttt tggaactgca attgctgctg taaaagacct caatcttgat ggatttaatg   2220

acatcgtgat aggagctccg ctggaagatg atcacggggg agctgtgtac atttatcatg   2280

gaagtggcaa gactataagg aaagagtatg cacaacgtat tccatcaggt ggggatggta   2340

agacactgaa attttttggc cagtctatcc acggagaaat ggatttaaat ggtgacggtc   2400

tgacagatgt gactattggg ggccttggtg gtgctgccct cttctggtcc cgagatgtgg   2460

ccgtagttaa agtgaccatg aattttgagc caaataaagt gaatattcaa aagaaaaact   2520

gccatatgga gggaaaggaa acagtatgca taaatgctac agtgtgtttt gatgtgaaat   2580

taaagtctaa agaagacacg atttatgaag ctgatttgca gtaccgtgtc accctagatt   2640

cactaagaca aatatcacga agttttttct ctggaactca agagagaaag gttcaaagga   2700

acatcacagt tcgaaaatca gaatgcacta agcactcctt ctacatgttg gcaagacaag   2760

catgactttc aggactctgt gagaataacg ttggacttta atcttaccga tccagaaaat   2820

gggcctgttc ttgatgattc tctaccaaac tcagtacatg aatatattcc ctttgccaaa   2880

gattgtggaa ataaggaaaa atgtatctca gacctcagcc tgcatgtcgc caccactgaa   2940

aaggacctgc tgattgtccg atcccagaat gataagttca acgttagcct cacagtcaaa   3000

aatacaaagg acagtgccta taacaccagg acaatagtgc attattctcc aaatctagtt   3060

ttttcaggaa ttgaggctat ccaaaaagac agttgtgaat ctaatcataa tatcacatgt   3120

aaagttggat atcccttcct gagaagagga gagatggtaa ctttcaaaat attgtttcag   3180

tttaacacat cctatctcat ggaaaatgtg accatttatt taagtgcaac aagtgacagc   3240

gaagaacctc ctgaaaccct ttctgataat gtagtaaaca tttctatccc ggtaaaatat   3300

gaagttggac tacagtttta cagctctgca agtgaatacc acatttcaat tgctgccaat   3360

gagacagtcc ctgaagttat taattctact gaggacattg gaaatgaaat taatatcttc   3420

tacttgatta gaaaaagtgg atcttttcca atgccagagc ttaagctgtc aatttcattc   3480

cccaatatga catcaaatgg ttaccctgtg ctgtacccaa ctggattgtc atcttctgag   3540

aatgcaaact gcagacccca tatctttgag gatcctttca gtatcaactc tggaaagaaa   3600

atgactacat caactgacca tctcaaacga ggcacaattc tggactgcaa tacatgtaaa   3660

tttgctacca tcacatgtaa tctcacttct tctgacatca gccaagtcaa tgtttcgctt   3720

atcttgtgga aaccaacttt tataaaatca tatttttcca gcttaaatct tactataagg   3780

ggagaacttc ggagtgaaaa tgcatctctg gttttaagta gcagcaatca aaaaagagag   3840

cttgctattc aaatatccaa agatgggcta ccgggcagag tgccattatg ggtcatcctg   3900

ctgagtgctt ttgccggatt gttgctgtta atgctgctca ttttagcact gtggaagatt   3960

ggattcttca aaagaccact gaaaaagaaa atggagaaat gaaatatttt atgaaagaaa   4020

ataataacaa ttattcaata atctatcctc aggtttgcct caaatatgtg acaagaaatg   4080

tataattcat gacatagtca tgtaactatg taatccatca gggattcatt acttggaaaa   4140

tgacaggtca tgcattatcc aaaaacaata ccaaaaagac atattttata aaatgacaaa   4200

aaatatttta cataattact catttttgtt gagtaagcaa aattacaaag tgtttttaaa   4260

aaaacctgta caaatatgtt tatgtattaa atcaccatcc aaaatattta aggaatatat   4320

aaaaagattt ttatgatcat agaaacatct attttcaaaa caatataaat taagcttttc   4380

cccttgattc ctgttggata tccatgttca gcatgacagt cagcactcgt aaatgccaag   4440

aaaagaatta cctgaaaaag atcatttctc cctattcaaa tgagaatatt ttcccttggt   4500

agaatccata tacaatatgg attgaaaatt aagtcaccaa gaatacattt agcatctttg   4560

tgttgggttc tatacctaaa aattttccct ccctgcccaa ggtgattgga aagtactgca   4620

attgagctaa aattttatct aggatggaaa atcaggatag actcgtttaa aaacaagtat   4680

attaaatggg ttaaattaag cttttacaga acatgcttaa ttttgatatt gagctctaaa   4740

tgcaaaactc ttttatactg aaaaaacact taaagtagtt ttgtgtggca tcacagtgat   4800

ttgtcatgaa aagccatata tgggggacat gctaaaatgg cttctgaatg aaatacgaca   4860

gcagagaaag atgccactga aatgctgaaa ttatctttgc tgagcagctt ttgaatgcta   4920

agggttccag tatgtgaccc aaagaaagag ttgtctcaac tccttggtac agggttcatt   4980

caaaccccca agctgtgaga gtgtgtttat ttttaatttt ttaaaaggta tttaatttcc   5040

aaccacactt cttatttttt tgaaaagaca attttccatt tcagtattac attttaccaa   5100

gaagtcactg ctttttaggt gtgttgcatc aatatttaaa taaaatccca gaaatgtatt   5160

ttaaagaatt tcaggtttga aaactcaaac caacaggaag atatcacacc tttgtatgtg   5220

cttctttgtt cttgaagtag tcattatggt tcattggaat ctactgtagc ataagctcct   5280

aggttgctcc atttcttagg aaaatagcaa tgaatgaatg tatagtagct gcatgtgtga   5340

actactgctg taaagtttgc tgacatttct gcaacaacat ttctccatct gatttaccag   5400

aacctgtaac aagaccagaa catgtattca tccagaaact cctgggctct gctttgttca   5460

aagaggagca aatccacata gaaattaaat gttataaatt tattttttta aactaatttc   5520

caaagaattt agctgaagac tcagagtcag cctacctctt gactctccac atccgcatct   5580

aagatcctga aggccaaagg aatgcgcctg tgggatgcca aagccatcag tagctggaag   5640

aaagaatacc tctttctaga ggtttggtgt cctcttgctg gcctgtcatt atttggaaat   5700

acgcgctttt ggaatttcct tcattttcgc tatttccagg ttcagaaatc atacctacca   5760

cttgttcttt ctttgcccag taaaactcag ggtttctctt attcagagtt accatgttgc   5820

acacccccag tgctcagcct gcccagaagc ccttctctga tctcagcaag atcttagtag   5880

taaagctaac ggatccattg aaattcatac tcagcatctg tgactactag acaaagccca   5940

tttactgaac cataagtgtg cacttttaaa ctaaattgtt aactgaaagg gaaaaaatag   6000

aaatgagggc attttgaagt ttttagaaaa gagaggaaga gctgttggcc agatcaaaga   6060

gatacttata agcccggcac aatttttaac ataagtcatt cctggctatt aagtaaaata   6120

tttcatgaac cagaagtcct gtttctctaa tattataatt tgttgaggtt tgtgtgtgtg   6180

tgtgtgtgca tgtgcagaca catgtacaca tataaattga atacaaaaat agctctataa   6240

caccaaaaaa cagagtttac agaaaataaa cacaaaagct atatctgcaa gacaagtttg   6300

attcatctag tttcatatag tttcatatag tttcattttt attaatattt aggtttaact   6360

tatagttctg caattattta aaaaacaagt acagagcgtt tgattaaaaa aagtcaacaa   6420

atgtttcaaa acagctttgt acaaatgtta taaaacatat ttaatgatta agaaatgtac   6480

tagactctat catttacttt taaaacattt aattagaaaa acaggtgata tttaagacta   6540

tttataaact tattggccaa attgccaaaa agtttctttt tctctaactt tggtattcta   6600

aataattgat tattgctccc attgtaaact gaaccatgta tgcactctct tttctgacca   6660

aactacaatg gtatattggt aaattattta acaacacact gtccaggagg gaaaaaaaaa   6720

acagtctctg atttgtatca tttgccaatt tccatggtcc aaatattctc tctccatttt   6780

caaactacca aagtgaccct aatcagctta caaaattcct ggaaatgtat ctgccacctc   6840

ttaccaacca gtgtgagctg acttcagcac accactgaga cagattacac gatagacaga   6900

tagatagata gatagataga tagatagata gatagataga tagatattga tagagaacat   6960

gttgtgtcta tatacatatc caatgacaca cagtataatc atgttttaaa ttatgccaaa   7020

agtactgatt atatcaagcc cagtaaacat aatgctacac agcacccatt ctttaatttt   7080

gatttctaaa attataacct tcctttgata ttaataaaat gttatgaact tgcaggagaa   7140

ggaaggagtt gaaagaagga aaatataaag ggtgatccac agtgaaaatc agacctacac   7200

aagccacaaa aaaattgtct cattttccca aggaattcaa agtcctgtga tacacattac   7260

aaaagatgac actttgtaaa tattttgaac ttctatgatc caatttcaac ttcattggtc   7320

caatttgtca aactattttc ctctgagcac tagattcatg ggcaatttaa tctctgaata   7380

ttttctgtgt cataagtgtg cttgaaaaga ggcttgtagt aaacagatat ttttacaaaa   7440

tttgatgctt ctgcaaccat aataatttta tctataaatg cgtatataca tatatatata   7500

tatatatata cacatacact cacatgcaga tatttacata tatagatatt ctcttttcct   7560

tttataaaat caaagtctag gctcaattgg aaaatggaaa tatttgcacc aaaagaaaaa   7620

agtgccattg ttgtgatcaa tggagtaaag ctggggtata gtagaggctg gggaatccct   7680

gcccatgttc tctccaaggc cacagcttgc acaccgtgaa tggtggcccc actggctcca   7740

tggagtgtgc cttcacgcgg gggaatgtcc ttgtccaaca cgctgtaatc tactccatgg   7800

gaactgactg tcctgctttt cacaacattg agaaacaggc ccagagcctg tctcatgtgc   7860

caggtgcagt cacattattg ttaaaataaa gtggcttctg acaaatcagt ttttcaaaat   7920

agcatcctat gtacttttca tttcttccaa caaccctcag gccccctttt gccagttttc   7980

tcccccaggg gagattttca agactactgg agaaaaatct gttaataaaa catttgctct   8040

gagt                                                                8044


<210>  2715
<211>  768
<212>  PRT
<213>  Homo sapiens

<400>  2715

Met Ala Pro Arg Pro Arg Ala Arg Pro Gly Val Ala Val Ala Cys Cys 
1               5                   10                  15


Trp Leu Leu Thr Val Val Leu Arg Cys Cys Val Ser Phe Asn Val Asp 
            20                  25                  30


Val Lys Asn Ser Met Thr Phe Ser Gly Pro Val Glu Asp Met Phe Gly 
        35                  40                  45


Tyr Thr Val Gln Gln Tyr Glu Asn Glu Glu Gly Lys Trp Val Leu Ile 
    50                  55                  60


Gly Ser Pro Leu Val Gly Gln Pro Lys Asn Arg Thr Gly Asp Val Tyr 
65                  70                  75                  80


Lys Cys Pro Val Gly Arg Gly Glu Ser Leu Pro Cys Val Lys Leu Asp 
                85                  90                  95


Leu Pro Val Asn Thr Ser Ile Pro Asn Val Thr Glu Val Lys Glu Asn 
            100                 105                 110


Met Thr Phe Gly Ser Thr Leu Val Thr Asn Pro Asn Gly Gly Phe Leu 
        115                 120                 125


Ala Cys Gly Pro Leu Tyr Ala Tyr Arg Cys Gly His Leu His Tyr Thr 
    130                 135                 140


Thr Gly Ile Cys Ser Asp Val Ser Pro Thr Phe Gln Val Val Asn Ser 
145                 150                 155                 160


Ile Ala Pro Val Gln Glu Cys Ser Thr Gln Leu Asp Ile Val Ile Val 
                165                 170                 175


Leu Asp Gly Ser Asn Ser Ile Tyr Pro Trp Asp Ser Val Thr Ala Phe 
            180                 185                 190


Leu Asn Asp Leu Leu Glu Arg Met Asp Ile Gly Pro Lys Gln Thr Gln 
        195                 200                 205


Val Gly Ile Val Gln Tyr Gly Glu Asn Val Thr His Glu Phe Asn Leu 
    210                 215                 220


Asn Lys Tyr Ser Ser Thr Glu Glu Val Leu Val Ala Ala Lys Lys Ile 
225                 230                 235                 240


Val Gln Arg Gly Gly Arg Gln Thr Met Thr Ala Leu Gly Ile Asp Thr 
                245                 250                 255


Ala Arg Lys Glu Ala Phe Thr Glu Ala Arg Gly Ala Arg Arg Gly Val 
            260                 265                 270


Lys Lys Val Met Val Ile Val Thr Asp Gly Glu Ser His Asp Asn His 
        275                 280                 285


Arg Leu Lys Lys Val Ile Gln Asp Cys Glu Asp Glu Asn Ile Gln Arg 
    290                 295                 300


Phe Ser Ile Ala Ile Leu Gly Ser Tyr Asn Arg Gly Asn Leu Ser Thr 
305                 310                 315                 320


Glu Lys Phe Val Glu Glu Ile Lys Ser Ile Ala Ser Glu Pro Thr Glu 
                325                 330                 335


Lys His Phe Phe Asn Val Ser Asp Glu Leu Ala Leu Val Thr Ile Val 
            340                 345                 350


Lys Thr Leu Gly Glu Arg Ile Phe Ala Leu Glu Ala Thr Ala Asp Gln 
        355                 360                 365


Ser Ala Ala Ser Phe Glu Met Glu Met Ser Gln Thr Gly Phe Ser Ala 
    370                 375                 380


His Tyr Ser Gln Asp Trp Val Met Leu Gly Ala Val Gly Ala Tyr Asp 
385                 390                 395                 400


Trp Asn Gly Thr Val Val Met Gln Lys Ala Ser Gln Ile Ile Ile Pro 
                405                 410                 415


Arg Asn Thr Thr Phe Asn Val Glu Ser Thr Lys Lys Asn Glu Pro Leu 
            420                 425                 430


Ala Ser Tyr Leu Gly Tyr Thr Val Asn Ser Ala Thr Ala Ser Ser Gly 
        435                 440                 445


Asp Val Leu Tyr Ile Ala Gly Gln Pro Arg Tyr Asn His Thr Gly Gln 
    450                 455                 460


Val Ile Ile Tyr Arg Met Glu Asp Gly Asn Ile Lys Ile Leu Gln Thr 
465                 470                 475                 480


Leu Ser Gly Glu Gln Ile Gly Ser Tyr Phe Gly Ser Ile Leu Thr Thr 
                485                 490                 495


Thr Asp Ile Asp Lys Asp Ser Asn Thr Asp Ile Leu Leu Val Gly Ala 
            500                 505                 510


Pro Met Tyr Met Gly Thr Glu Lys Glu Glu Gln Gly Lys Val Tyr Val 
        515                 520                 525


Tyr Ala Leu Asn Gln Thr Arg Phe Glu Tyr Gln Met Ser Leu Glu Pro 
    530                 535                 540


Ile Lys Gln Thr Cys Cys Ser Ser Arg Gln His Asn Ser Cys Thr Thr 
545                 550                 555                 560


Glu Asn Lys Asn Glu Pro Cys Gly Ala Arg Phe Gly Thr Ala Ile Ala 
                565                 570                 575


Ala Val Lys Asp Leu Asn Leu Asp Gly Phe Asn Asp Ile Val Ile Gly 
            580                 585                 590


Ala Pro Leu Glu Asp Asp His Gly Gly Ala Val Tyr Ile Tyr His Gly 
        595                 600                 605


Ser Gly Lys Thr Ile Arg Lys Glu Tyr Ala Gln Arg Ile Pro Ser Gly 
    610                 615                 620


Gly Asp Gly Lys Thr Leu Lys Phe Phe Gly Gln Ser Ile His Gly Glu 
625                 630                 635                 640


Met Asp Leu Asn Gly Asp Gly Leu Thr Asp Val Thr Ile Gly Gly Leu 
                645                 650                 655


Gly Gly Ala Ala Leu Phe Trp Ser Arg Asp Val Ala Val Val Lys Val 
            660                 665                 670


Thr Met Asn Phe Glu Pro Asn Lys Val Asn Ile Gln Lys Lys Asn Cys 
        675                 680                 685


His Met Glu Gly Lys Glu Thr Val Cys Ile Asn Ala Thr Val Cys Phe 
    690                 695                 700


Asp Val Lys Leu Lys Ser Lys Glu Asp Thr Ile Tyr Glu Ala Asp Leu 
705                 710                 715                 720


Gln Tyr Arg Val Thr Leu Asp Ser Leu Arg Gln Ile Ser Arg Ser Phe 
                725                 730                 735


Phe Ser Gly Thr Gln Glu Arg Lys Val Gln Arg Asn Ile Thr Val Arg 
            740                 745                 750


Lys Ser Glu Cys Thr Lys His Ser Phe Tyr Met Leu Ala Arg Gln Ala 
        755                 760                 765


<210>  2716
<211>  8538
<212>  DNA
<213>  Homo sapiens

<400>  2716
ctcccgaagg tccagccctt acccgccttc ctaccacctt aggggatttg gcccggagaa     60

cgagatcacc ctctcaatga aaggcagatg tccctttaag gtttgcttct acagcccgtg    120

gactttagcc taaacacgga cccgcgaagc tggctttatt tgtccatgtc tcggacagag    180

cctgggaagc tgccagtgag atttcagaga ccaagagcgc gaaggggcgg gcgatgtggc    240

aatccgtctg ggatgtgaaa agcgtggagc gcatttagag gaattcgacg aaaacacagg    300

aaatcactcc tctcccgctc ctgggcgccg ctgccactgg ggcagaggac tgggaaccgc    360

ggcagcggga taagtggccc agccagagag cgcagctccc gcgcccggtc ctgccctgcg    420

aaccagcgcg gccccctggc gctgaggctg ctccggccat ggcccctcgg ccccgcgccc    480

gcccaggggt cgctgtcgcc tgctgctggc tcctcactgt tgttctacgc tgctgcgtat    540

cattcaatgt tgatgtgaaa aattcaatga ctttcagcgg cccggtggaa gacatgtttg    600

gatatactgt tcaacaatat gaaaatgaag aaggaaaatg ggtgcttatt ggttctccgt    660

tagttggcca acccaaaaac agaactggag atgtctataa gtgtccagtt gggagaggtg    720

aatcattacc ttgtgtaaag ttggatctac cagttaatac atcaattccc aatgtcacag    780

aagtaaagga gaacatgaca tttggatcaa ctttagtcac caacccaaat ggaggatttc    840

tggcttgtgg gcccttatat gcctatagat gtggacattt gcattacaca actggaatct    900

gttctgacgt cagccccaca tttcaagtcg tgaattccat tgcccctgta caagaatgca    960

gcactcaact ggacatagtc atagtgctgg atggttccaa cagtatttac ccatgggaca   1020

gtgttacagc ttttttaaat gaccttcttg aaagaatgga tattggtcct aaacagacac   1080

aggttggaat tgtacagtat ggagaaaacg tgacccatga gttcaacctc aataagtatt   1140

cttccaccga agaggtactt gttgcagcaa agaaaatagt ccagagaggt ggccgccaga   1200

ctatgacagc tcttggaata gacacagcaa gaaaggaggc attcacggaa gcccggggtg   1260

cccgaagagg agttaaaaaa gtcatggtta ttgtgacaga tggagagtct catgacaatc   1320

atcgactgaa gaaggtcatc caagactgtg aagatgaaaa cattcaacgg ttttccatag   1380

ctattcttgg cagctataac cgaggaaatt taagcactga aaaatttgtg gaggaaataa   1440

aatcaattgc aagtgaaccc actgaaaagc atttcttcaa tgtctctgat gaattggctc   1500

tagtcaccat tgttaaaact ctgggagaaa gaatatttgc cctggaagcc acagctgacc   1560

agtcagcagc ttcatttgaa atggaaatgt ctcagactgg cttcagtgct cattattcac   1620

aggactgggt catgcttgga gcagtaggag cctatgattg gaatggaaca gttgtcatgc   1680

agaaggctag tcaaatcata atccctcgaa acacaacctt taatgttgag tctaccaaaa   1740

agaatgaacc gcttgcttct tatttaggtt acactgtaaa ctctgctact gcttcttctg   1800

gagatgtgct ctatattgct ggacagcctc ggtacaatca tacaggccag gtcattatct   1860

acaggatgga agatggaaac atcaaaattc tccagacgct cagtggagaa cagattggtt   1920

cctactttgg cagtatttta acaacaactg acattgacaa ggattctaat actgacattc   1980

ttctagtcgg agcccctatg tacatgggaa cagagaagga ggagcaagga aaagtgtatg   2040

tgtatgctct caatcagaca aggtttgaat atcaaatgag cctggaacct attaagcaga   2100

cgtgctgttc atctcggcag cacaattcat gcacaacaga aaacaaaaat gagccatgcg   2160

gggctcgttt tggaactgca attgctgctg taaaagacct caatcttgat ggatttaatg   2220

acatcgtgat aggagctccg ctggaagatg atcacggggg agctgtgtac atttatcatg   2280

gaagtggcaa gactataagg aaagagtatg cacaacgtat tccatcaggt ggggatggta   2340

agacactgaa attttttggc cagtctatcc acggagaaat ggatttaaat ggtgacggtc   2400

tgacagatgt gactattggg ggccttggtg gtgctgccct cttctggtcc cgagatgtgg   2460

ccgtagttaa agtgaccatg aattttgagc caaataaagt gaatattcaa aagaaaaact   2520

gccatatgga gggaaaggaa acagtatgca taaatgctac agtgtgtttt gatgtgaaat   2580

taaagtctaa agaagacacg atttatgaag ctgatttgca gtaccgtgtc accctagatt   2640

cactaagaca aatatcacga agttttttct ctggaactca agagagaaag gttcaaagga   2700

acatcacagt tcgaaaatca gaatgcacta agcactcctt ctacatgttg gcaagacaag   2760

catgactttc aggactctgt gagaataacg ttggacttta atcttaccga tccagaaaat   2820

gggcctgttc ttgatgattc tctaccaaac tcagtacatg aatatattcc ctttgccaaa   2880

gattgtggaa ataaggaaaa atgtatctca gacctcagcc tgcatgtcgc caccactgaa   2940

aaggacctgc tgattgtccg atcccagaat gataagttca acgttagcct cacagtcaaa   3000

aatacaaagg acagtgccta taacaccagg acaatagtgc attattctcc aaatctagtt   3060

ttttcaggaa ttgaggctat ccaaaaagac agttgtgaat ctaatcataa tatcacatgt   3120

aaagttggat atcccttcct gagaagagga gagatggtaa ctttcaaaat attgtttcag   3180

tttaacacat cctatctcat ggaaaatgtg accatttatt taagtgcaac aagtgacagc   3240

gaagaacctc ctgaaaccct ttctgataat gtagtaaaca tttctatccc ggtaaaatat   3300

gaagttggac tacagtttta cagctctgca agtgaatacc acatttcaat tgctgccaat   3360

gagacagtcc ctgaagttat taattctact gaggacattg gaaatgaaat taatatcttc   3420

tacttgatta gaaaaagtgg atcttttcca atgccagagc ttaagctgtc aatttcattc   3480

cccaatatga catcaaatgg ttaccctgtg ctgtacccaa ctggattgtc atcttctgag   3540

aatgcaaact gcagacccca tatctttgag gatcctttca gtatcaactc tggaaagaaa   3600

atgactacat caactgacca tctcaaacga ggcacaattc tggactgcaa tacatgtaaa   3660

tttgctacca tcacatgtaa tctcacttct tctgacatca gccaagtcaa tgtttcgctt   3720

atcttgtgga aaccaacttt tataaaatca tatttttcca gcttaaatct tactataagg   3780

ggagaacttc ggagtgaaaa tgcatctctg gttttaagta gcagcaatca aaaaagagag   3840

cttgctattc aaatatccaa agatgggcta ccgggcagag tgccattatg ggtcatcctg   3900

ctgagtgctt ttgccggatt gttgctgtta atgctgctca ttttagcact gtggaagatt   3960

ggattcttca aaagaccact gaaaaagaaa atggagaaat gaaatatttt atgaaagaaa   4020

ataataacaa ttattcaata atctatcctc aggtttgcct caaatatgtg acaagaaatg   4080

tataattcat gacatagtca tgtaactatg taatccatca gggattcatt acttggaaaa   4140

tgacaggtca tgcattatcc aaaaacaata ccaaaaagac atattttata aaatgacaaa   4200

aaatatttta cataattact catttttgtt gagtaagcaa aattacaaag tgtttttaaa   4260

aaaacctgta caaatatgtt tatgtattaa atcaccatcc aaaatattta aggaatatat   4320

aaaaagattt ttatgatcat agaaacatct attttcaaaa caatataaat taagcttttc   4380

cccttgattc ctgttggata tccatgttca gcatgacagt cagcactcgt aaatgccaag   4440

aaaagaatta cctgaaaaag atcatttctc cctattcaaa tgagaatatt ttcccttggt   4500

agaatccata tacaatatgg attgaaaatt aagtcaccaa gaatacattt agcatctttg   4560

tgttgggttc tatacctaaa aattttccct ccctgcccaa ggtgattgga aagtactgca   4620

attgagctaa aattttatct aggatggaaa atcaggatag actcgtttaa aaacaagtat   4680

attaaatggg ttaaattaag cttttacaga acatgcttaa ttttgatatt gagctctaaa   4740

tgcaaaactc ttttatactg aaaaaacact taaagtagtt ttgtgtggca tcacagtgat   4800

ttgtcatgaa aagccatata tgggggacat gctaaaatgg cttctgaatg aaatacgaca   4860

gcagagaaag atgccactga aatgctgaaa ttatctttgc tgagcagctt ttgaatgcta   4920

agggttccag tatgtgaccc aaagaaagag ttgtctcaac tccttggtac agggttcatt   4980

caaaccccca agctgtgaga gtgtgtttat ttttaatttt ttaaaaggta tttaatttcc   5040

aaccacactt cttatttttt tgaaaagaca attttccatt tcagtattac attttaccaa   5100

gaagtcactg ctttttaggt gtgttgcatc aatatttaaa taaaatccca gaaatgtatt   5160

ttaaagaatt tcaggtttga aaactcaaac caacaggaag atatcacacc tttgtatgtg   5220

cttctttgtt cttgaagtag tcattatggt tcattggaat ctactgtagc ataagctcct   5280

aggttgctcc atttcttagg aaaatagcaa tgaatgaatg tatagtagct gcatgtgtga   5340

actactgctg taaagtttgc tgacatttct gcaacaacat ttctccatct gatttaccag   5400

aacctgtaac aagaccagaa catgtattca tccagaaact cctgggctct gctttgttca   5460

aagaggagca aatccacata gaaattaaat gttataaatt tattttttta aactaatttc   5520

caaagaattt agctgaagac tcagagtcag cctacctctt gactctccac atccgcatct   5580

aagatcctga aggccaaagg aatgcgcctg tgggatgcca aagccatcag tagctggaag   5640

aaagaatacc tctttctaga ggtttggtgt cctcttgctg gcctgtcatt atttggaaat   5700

acgcgctttt ggaatttcct tcattttcgc tatttccagg ttcagaaatc atacctacca   5760

cttgttcttt ctttgcccag taaaactcag ggtttctctt attcagagtt accatgttgc   5820

acacccccag tgctcagcct gcccagaagc ccttctctga tctcagcaag atcttagtag   5880

taaagctaac ggatccattg aaattcatac tcagcatctg tgactactag acaaagccca   5940

tttactgaac cataagtgtg cacttttaaa ctaaattgtt aactgaaagg gaaaaaatag   6000

aaatgagggc attttgaagt ttttagaaaa gagaggaaga gctgttggcc agatcaaaga   6060

gatacttata agcccggcac aatttttaac ataagtcatt cctggctatt aagtaaaata   6120

tttcatgaac cagaagtcct gtttctctaa tattataatt tgttgaggtt tgtgtgtgtg   6180

tgtgtgtgca tgtgcagaca catgtacaca tataaattga atacaaaaat agctctataa   6240

caccaaaaaa cagagtttac agaaaataaa cacaaaagct atatctgcaa gacaagtttg   6300

attcatctag tttcatatag tttcatatag tttcattttt attaatattt aggtttaact   6360

tatagttctg caattattta aaaaacaagt acagagcgtt tgattaaaaa aagtcaacaa   6420

atgtttcaaa acagctttgt acaaatgtta taaaacatat ttaatgatta agaaatgtac   6480

tagactctat catttacttt taaaacattt aattagaaaa acaggtgata tttaagacta   6540

tttataaact tattggccaa attgccaaaa agtttctttt tctctaactt tggtattcta   6600

aataattgat tattgctccc attgtaaact gaaccatgta tgcactctct tttctgacca   6660

aactacaatg gtatattggt aaattattta acaacacact gtccaggagg gaaaaaaaaa   6720

acagtctctg atttgtatca tttgccaatt tccatggtcc aaatattctc tctccatttt   6780

caaactacca aagtgaccct aatcagctta caaaattcct ggaaatgtat ctgccacctc   6840

ttaccaacca gtgtgagctg acttcagcac accactgaga cagattacac gatagacaga   6900

tagatagata gatagataga tagatagata gatagataga tagatattga tagagaacat   6960

gttgtgtcta tatacatatc caatgacaca cagtataatc atgttttaaa ttatgccaaa   7020

agtactgatt atatcaagcc cagtaaacat aatgctacac agcacccatt ctttaatttt   7080

gatttctaaa attataacct tcctttgata ttaataaaat gttatgaact tgcaggagaa   7140

ggaaggagtt gaaagaagga aaatataaag ggtgatccac agtgaaaatc agacctacac   7200

aagccacaaa aaaattgtct cattttccca aggaattcaa agtcctgtga tacacattac   7260

aaaagatgac actttgtaaa tattttgaac ttctatgatc caatttcaac ttcattggtc   7320

caatttgtca aactattttc ctctgagcac tagattcatg ggcaatttaa tctctgaata   7380

ttttctgtgt cataagtgtg cttgaaaaga ggcttgtagt aaacagatat ttttacaaaa   7440

tttgatgctt ctgcaaccat aataatttta tctataaatg cgtatataca tatatatata   7500

tatatatata cacatacact cacatgcaga tatttacata tatagatatt ctcttttcct   7560

tttataaaat caaagtctag gctcaattgg aaaatggaaa tatttgcacc aaaagaaaaa   7620

agtgccattg ttgtgatcaa tggagtaaag ctggggtata gtagaggctg gggaatccct   7680

gcccatgttc tctccaaggc cacagcttgc acaccgtgaa tggtggcccc actggctcca   7740

tggagtgtgc cttcacgcgg gggaatgtcc ttgtccaaca cgctgtaatc tactccatgg   7800

gaactgactg tcctgctttt cacaacattg agaaacaggc ccagagcctg tctcatgtgc   7860

caggtgcagt cacattattg ttaaaataaa gtggcttctg acaaatcagt ttttcaaaat   7920

agcatcctat gtacttttca tttcttccaa caaccctcag gccccctttt gccagttttc   7980

tcccccaggg gagattttca agactactgg agaaaaatct gttaataaaa catttgctct   8040

gagtaccagc ttcagtgact caatcattta tacaggattt cagtgttttg ttctgcagcg   8100

gtgttctaaa gggttcacat agtataatgg aggagggaca aagcagaata tacttccaag   8160

ctggaacatc tttaagacat ttacaaactg ttatgggaca ctatcagcaa ctacgcctgg   8220

ggaagctagc aggatttagc tcttcaatgg ccctccaaat gcacccaaca atcgccaacc   8280

tcacccatgg aaatcatcta aaaaatgaaa agaagggcct taaagtcctc acatggatgc   8340

tgtatttata actaaaatgt acagtttaat tctaaatagc aggcttttaa atgcaaacag   8400

cttccaggtg agtcctctgg ctgccaatca gactgctgat tctaaaccat tctcacacag   8460

aatttctgaa accaacacca ggtattaatt gttaactgca gtgaaaggaa accaaggcac   8520

attacaaaag gctaaatg                                                 8538


<210>  2717
<211>  768
<212>  PRT
<213>  Homo sapiens

<400>  2717

Met Ala Pro Arg Pro Arg Ala Arg Pro Gly Val Ala Val Ala Cys Cys 
1               5                   10                  15


Trp Leu Leu Thr Val Val Leu Arg Cys Cys Val Ser Phe Asn Val Asp 
            20                  25                  30


Val Lys Asn Ser Met Thr Phe Ser Gly Pro Val Glu Asp Met Phe Gly 
        35                  40                  45


Tyr Thr Val Gln Gln Tyr Glu Asn Glu Glu Gly Lys Trp Val Leu Ile 
    50                  55                  60


Gly Ser Pro Leu Val Gly Gln Pro Lys Asn Arg Thr Gly Asp Val Tyr 
65                  70                  75                  80


Lys Cys Pro Val Gly Arg Gly Glu Ser Leu Pro Cys Val Lys Leu Asp 
                85                  90                  95


Leu Pro Val Asn Thr Ser Ile Pro Asn Val Thr Glu Val Lys Glu Asn 
            100                 105                 110


Met Thr Phe Gly Ser Thr Leu Val Thr Asn Pro Asn Gly Gly Phe Leu 
        115                 120                 125


Ala Cys Gly Pro Leu Tyr Ala Tyr Arg Cys Gly His Leu His Tyr Thr 
    130                 135                 140


Thr Gly Ile Cys Ser Asp Val Ser Pro Thr Phe Gln Val Val Asn Ser 
145                 150                 155                 160


Ile Ala Pro Val Gln Glu Cys Ser Thr Gln Leu Asp Ile Val Ile Val 
                165                 170                 175


Leu Asp Gly Ser Asn Ser Ile Tyr Pro Trp Asp Ser Val Thr Ala Phe 
            180                 185                 190


Leu Asn Asp Leu Leu Glu Arg Met Asp Ile Gly Pro Lys Gln Thr Gln 
        195                 200                 205


Val Gly Ile Val Gln Tyr Gly Glu Asn Val Thr His Glu Phe Asn Leu 
    210                 215                 220


Asn Lys Tyr Ser Ser Thr Glu Glu Val Leu Val Ala Ala Lys Lys Ile 
225                 230                 235                 240


Val Gln Arg Gly Gly Arg Gln Thr Met Thr Ala Leu Gly Ile Asp Thr 
                245                 250                 255


Ala Arg Lys Glu Ala Phe Thr Glu Ala Arg Gly Ala Arg Arg Gly Val 
            260                 265                 270


Lys Lys Val Met Val Ile Val Thr Asp Gly Glu Ser His Asp Asn His 
        275                 280                 285


Arg Leu Lys Lys Val Ile Gln Asp Cys Glu Asp Glu Asn Ile Gln Arg 
    290                 295                 300


Phe Ser Ile Ala Ile Leu Gly Ser Tyr Asn Arg Gly Asn Leu Ser Thr 
305                 310                 315                 320


Glu Lys Phe Val Glu Glu Ile Lys Ser Ile Ala Ser Glu Pro Thr Glu 
                325                 330                 335


Lys His Phe Phe Asn Val Ser Asp Glu Leu Ala Leu Val Thr Ile Val 
            340                 345                 350


Lys Thr Leu Gly Glu Arg Ile Phe Ala Leu Glu Ala Thr Ala Asp Gln 
        355                 360                 365


Ser Ala Ala Ser Phe Glu Met Glu Met Ser Gln Thr Gly Phe Ser Ala 
    370                 375                 380


His Tyr Ser Gln Asp Trp Val Met Leu Gly Ala Val Gly Ala Tyr Asp 
385                 390                 395                 400


Trp Asn Gly Thr Val Val Met Gln Lys Ala Ser Gln Ile Ile Ile Pro 
                405                 410                 415


Arg Asn Thr Thr Phe Asn Val Glu Ser Thr Lys Lys Asn Glu Pro Leu 
            420                 425                 430


Ala Ser Tyr Leu Gly Tyr Thr Val Asn Ser Ala Thr Ala Ser Ser Gly 
        435                 440                 445


Asp Val Leu Tyr Ile Ala Gly Gln Pro Arg Tyr Asn His Thr Gly Gln 
    450                 455                 460


Val Ile Ile Tyr Arg Met Glu Asp Gly Asn Ile Lys Ile Leu Gln Thr 
465                 470                 475                 480


Leu Ser Gly Glu Gln Ile Gly Ser Tyr Phe Gly Ser Ile Leu Thr Thr 
                485                 490                 495


Thr Asp Ile Asp Lys Asp Ser Asn Thr Asp Ile Leu Leu Val Gly Ala 
            500                 505                 510


Pro Met Tyr Met Gly Thr Glu Lys Glu Glu Gln Gly Lys Val Tyr Val 
        515                 520                 525


Tyr Ala Leu Asn Gln Thr Arg Phe Glu Tyr Gln Met Ser Leu Glu Pro 
    530                 535                 540


Ile Lys Gln Thr Cys Cys Ser Ser Arg Gln His Asn Ser Cys Thr Thr 
545                 550                 555                 560


Glu Asn Lys Asn Glu Pro Cys Gly Ala Arg Phe Gly Thr Ala Ile Ala 
                565                 570                 575


Ala Val Lys Asp Leu Asn Leu Asp Gly Phe Asn Asp Ile Val Ile Gly 
            580                 585                 590


Ala Pro Leu Glu Asp Asp His Gly Gly Ala Val Tyr Ile Tyr His Gly 
        595                 600                 605


Ser Gly Lys Thr Ile Arg Lys Glu Tyr Ala Gln Arg Ile Pro Ser Gly 
    610                 615                 620


Gly Asp Gly Lys Thr Leu Lys Phe Phe Gly Gln Ser Ile His Gly Glu 
625                 630                 635                 640


Met Asp Leu Asn Gly Asp Gly Leu Thr Asp Val Thr Ile Gly Gly Leu 
                645                 650                 655


Gly Gly Ala Ala Leu Phe Trp Ser Arg Asp Val Ala Val Val Lys Val 
            660                 665                 670


Thr Met Asn Phe Glu Pro Asn Lys Val Asn Ile Gln Lys Lys Asn Cys 
        675                 680                 685


His Met Glu Gly Lys Glu Thr Val Cys Ile Asn Ala Thr Val Cys Phe 
    690                 695                 700


Asp Val Lys Leu Lys Ser Lys Glu Asp Thr Ile Tyr Glu Ala Asp Leu 
705                 710                 715                 720


Gln Tyr Arg Val Thr Leu Asp Ser Leu Arg Gln Ile Ser Arg Ser Phe 
                725                 730                 735


Phe Ser Gly Thr Gln Glu Arg Lys Val Gln Arg Asn Ile Thr Val Arg 
            740                 745                 750


Lys Ser Glu Cys Thr Lys His Ser Phe Tyr Met Leu Ala Arg Gln Ala 
        755                 760                 765


<210>  2718
<211>  389
<212>  DNA
<213>  Homo sapiens

<400>  2718
ggtaggctct ctgcttagtt tacataacat taaattacta atagcatgat tattatctga     60

ttatgagtgt tattgtcaat tatcttaaaa tcagtcataa aacaactcat ataaactgtt    120

tctcaatgtt caaaaatgtt tactgattta tttaacttcc agggtgctta ttggttctcc    180

gttagttggc caacccaaaa acagaactgg agatgtctat aagtgtccag ttgggagagg    240

tgaatcatta ccttgtgtaa agttggatct accaggtatg taaaattaaa aaaatctggt    300

tttaggccag actgcagtga atggtaattg cgccactgca ctccagcctg ggaacaagag    360

caaaactcca tctcaaaaaa aaaaaaaaa                                      389


<210>  2719
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  2719

Lys Asn Leu Val Leu Gly Gln Thr Ala Val Asn Gly Asn Cys Ala Thr 
1               5                   10                  15


Ala Leu Gln Pro Gly Asn Lys Ser Lys Thr Pro Ser Gln Lys Lys Lys 
            20                  25                  30


<210>  2720
<211>  556
<212>  DNA
<213>  Homo sapiens

<400>  2720
aaatccacat acagtcttaa catgaaaaca acctctggaa caaacattaa tacatcaatt     60

cccaatgtca cagaagtaaa ggagaacatg acatttggat caactttagt caccaaccca    120

aatggaggat ttctggcttg tgggccctta tatgcctata gatgtggaca tttgcattac    180

acaactggaa tctgttctga cgtcagcccc acatttcaag tcgtgaattc cattgcccct    240

gtacaagaat gcagcactca actggacata gtcatagtgc tggatggttc caacagtatt    300

tacccatggg acagtgttac agctttttta aatgaccttc ttgaaagaat ggatattggt    360

cctaaacaga cacaggactt tactttggga gaagtttctg aggcactgaa aaagcagact    420

gactgcgtta atgtttgcca cacctacatt aaatttggaa cataatatgt gcacatatat    480

atacatacat gtgtcttcat gtgtctgtgt atatttatgt ctctcttaat attttgatat    540

ctatgtatat ataatt                                                    556


<210>  2721
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  2721

Met Lys Thr Thr Ser Gly Thr Asn Ile Asn Thr Ser Ile Pro Asn Val 
1               5                   10                  15


Thr Glu Val Lys Glu Asn Met Thr Phe Gly Ser Thr Leu Val Thr Asn 
            20                  25                  30


Pro Asn Gly Gly Phe Leu Ala Cys Gly Pro Leu Tyr Ala Tyr Arg Cys 
        35                  40                  45


Gly His Leu His Tyr Thr Thr Gly Ile Cys Ser Asp Val Ser Pro Thr 
    50                  55                  60


Phe Gln Val Val Asn Ser Ile Ala Pro Val Gln Glu Cys Ser Thr Gln 
65                  70                  75                  80


Leu Asp Ile Val Ile Val Leu Asp Gly Ser Asn Ser Ile Tyr Pro Trp 
                85                  90                  95


Asp Ser Val Thr Ala Phe Leu Asn Asp Leu Leu Glu Arg Met Asp Ile 
            100                 105                 110


Gly Pro Lys Gln Thr Gln Asp Phe Thr Leu Gly Glu Val Ser Glu Ala 
        115                 120                 125


Leu Lys Lys Gln Thr Asp Cys Val Asn Val Cys His Thr Tyr Ile Lys 
    130                 135                 140


Phe Gly Thr 
145


<210>  2722
<211>  6369
<212>  DNA
<213>  Homo sapiens

<400>  2722
gtcattccca aaaacctttg gttaaacgtt gcttaaagca gatgtggaga attcaactta     60

aagatgccac tgcaagtaag aaaatattaa gaatcttatt tctgagcaca gtatttataa    120

tatatgactt ctctctgtcc aaaaaggaaa tttttgggta tgttttctac agtgtgctga    180

gattttcttt tctgtttcag aaattatttc attagcttac tcacaagtga gggtatatga    240

cattttgcca acataaagtc taatacatgt aagatttctt tcaaaataga aaagcattca    300

gaaaaggcag gacaaatacc ttgtgttttt tttcacccaa aataatattc taaatctgaa    360

atgaagtttt caaaatgttt ctttgtgggg gtcacaaatt gagaagagac tgagtgtatt    420

ttttcataaa ctgtgtggat tgcaagttgt aaggctatga aaaatcttat gaaggaagca    480

gaggcagagg ctctgttaga aaaatcccat gcttatcaat aaggatcagg aaactgtaag    540

aactcaagct gtcaaacatc tgtctcagga catagtccta ccccatcttt ctattaccca    600

aactgcctta tgccaataca ggcattgcaa gtgaatttgg tggtgaaaat acagctggga    660

ttatgttccc ctgcctcctc cacccacagt ttgctgaatt ctattcctgc catacagctt    720

ccaaaggaga aggaaagatg tgaggcaatg tcatggcatc aagacagatc atacctgttt    780

cccattacct cactagatcc tggccctttt cccaagaagt gaattatgag agctgacaga    840

attcattctt cataaatcca tgcaaagggc tatgccatcc attttagcct ttttttcctc    900

tttttttttt ctctttattt gagacagagt ttctctctta ttgcccaggc tggagtgcag    960

tggcatgatc tctgctcact gcaacctcca cctcctgggt tcaagtgatt ctcctgcctc   1020

agcctcctga gtaactggga ttacaggcgc ctgctaccat ccccggctaa ttttttatat   1080

ttttggtaga gaccgggttt catcatgttg gccagactgg tctcgaactc ctgacctcag   1140

gtgatccacc tgcctcggat tcccaaagtg ctgggattac aggcatgcac caccgcgccc   1200

agcccttttc ttccatctta ttcttttctt tttcaggaaa cactattaag cttaaatatt   1260

tataattatt ttccttcttt taaaattagg ctttacttgg ctctggctct ctttttcttt   1320

tcttctttct tgtctttaga cacccaagcc tcaattagta actacgctaa ctggtagtta   1380

ctgtccctga gattatttca gctaatattt ttagttatca agtataagtc atcaaagaga   1440

gttaactaaa taatctcaca actcctagcc tcaaacataa tttttaactc atttttaaag   1500

gaggcctttt atcaagttac attcacagct ctgcaaatta cacacacaca cacacacaca   1560

caaacacaca cgtactaaca ctctcattct actcccttct ttatatttct tagcagagtg   1620

gcatgaaata aaacagcctt cattttgcac attcttcttt tccattttat gtatgtataa   1680

acatggcctg aaagattcat tttaaaacaa tattgtggtt agtaatacaa acatgtaaca   1740

cattacatgt tcgaaaaaat attttagatt ctattatgta taataataaa aaaccctcaa   1800

agaaagatga aggaatgaga atgtgaggaa tattcataaa ggataatatg cctgaggaat   1860

agtgttcctt tagcacttgt aagaataaac atactgtata aaaacttttg ttccttttta   1920

acatttttga aagaaagtca aacctacttt acagtaaaat acttggtaag tgagttagaa   1980

aaatgatctt tttctcagtg agaagtgcta ttctgtggca ttttgaaaaa taatcttact   2040

tctgctccac tgaagaaatc tggttattaa aagagttatt ccttttataa aatcaaaatc   2100

tgcatgtggc aatttttatt cattgatatg gctctcttct caaaacacaa agaacaaatc   2160

taacttttca ctcaaaaatt aatcttaaag acacaattta tgctcttcct gtaagcagcc   2220

tgagatgatc tcttaaaatg gtttactatt cacttgaccc agaacaaccc aaaaaatcat   2280

tcaaatcaag agattgaaat cttcgtgttc actttaagaa catccatgaa gctacccagg   2340

caatcaaggg ttatgtatat ctgaaaagcc accaagtatc tgaaagatgt gactttacag   2400

aagcagtgtg tgccgttcca tcattgcaat ggtggagctg gtagatgtgt ccaaagccaa   2460

accgtggagc tggacagagg gtttatggcc ccaaaagagt gctgaaagtt tgttgcacat   2520

gcatacaaat gtaaaaagca gtgctgatct taaaggtttg tatgtagagt ctcttgatca   2580

ttgtgtacat ctaggtgggc gaagcaccca agatacactg gctctgttta cagggctcat   2640

ggtcagatta acccatacgt gacctccacc cccactatcg cacccaccgc actgaaatga   2700

tgcttactga aatagaacaa atttttctaa gccagaggag gaggttgcat agaagaaaaa   2760

ggtattccag aagaaaccga agaaacaaaa ataatgaccc aggaataatt tcaatataaa   2820

atatatgcaa ataaaatcaa aagtagaaaa aagacaatca aaattttaaa gagcatggaa   2880

gctcaattaa aatagaggag agaaccgggc acaatggctc acgcctgtaa tcccagcact   2940

tcgggaggct gaggcgagtg catcaggagg tcaggagatt gagaccatcc tggctaacac   3000

ggtgaaaccc cgtcttacta aaaatacaaa aaattagcca ggcgtggtgg cgggcgcctg   3060

tagtcccagc tactcgggag gctgaggcag gagaatggcg tgaacccggg aggcggagct   3120

tgcagtgagc cgagatcgcg ccactgcact ccaacctgga caacagagca agactccatc   3180

tcaaaaaaaa aaaaaaaagg aggaaagatc agatacgtga aaaatgattc aagctctgtg   3240

ttgaataaag tcacattaaa atcacagaaa ggtactgttg ttagacaatg tttaacacct   3300

attaaaacat acacaaattt aaataatagt gatgatacac aaagcctggg acagtttcat   3360

gaaattgtct ttcatatggc ggttcataga acaaagtagt acaaattttc tggaaacaat   3420

tttctagaca ctataagaac cattaaaaac gtgatccagt gatctattcc ttgaaatgta   3480

ctgtcaaaaa atccagaaga gggacaaatt taaatgctcc aaggtgtctt tgaaatctga   3540

agcataatac caaaaatatt aaaaccacct gaattctagt gttttatcgg gaaatggcca   3600

tgtaatataa atgcaatgtc tttatgcttt aaccaagaga aatcatcttc aattatttaa   3660

aattacaatt ttaaaagcta gtagcagcac agaaaaggtt tacattttct atgattccaa   3720

ttatatgaaa agtgttaatt tctgtagtgc agacacatat atccaaatga aatacaattg   3780

atttattaca aattggggtg gggatgtgca attttttatg tgtgtcatca ttgttatatc   3840

atttgtgatt ttaaataatg aaaaactcag attgggggaa aataacttct caggagaaag   3900

cagttgtggt agatagagag catattaaaa gcttccacca aaacaaattc ttacgtgcat   3960

tgaagaaaaa atattatttt caaaatataa ccatataaaa atgattatct tggccattta   4020

aaaagagtct taatttatta catgaagcct ttaagggtcc aggtggtata cctggaatct   4080

ttcttttgtt aggttacact gtaaactctg ctactgcttc ttctggagat gtgctctata   4140

ttgctggaca gcctcggtac aatcatacag gccaggtcat tatctacagg atggaagatg   4200

gaaacatcaa aattctccag acgctcagtg gagaacagat tggttcctac tttggcagta   4260

ttttaacaac aactgacatt gacaaggatt ctaatactga cattcttcta gtcggagccc   4320

ctatgtacat gggaacagag aaggaggagc aaggaaaagt gtatgtgtat gctctcaatc   4380

agacaaggtt tgaatatcaa atgagcctgg aacctattaa gcagacgtgc tgttcatctc   4440

ggcagcacaa ttcatgcaca acagaaaaca aaaatgagcc atgcggggct cgttttggaa   4500

ctgcaattgc tgctgtaaaa gacctcaatc ttgatggatt taatgacatc gtgataggag   4560

ctccgctgga agatgatcac gggggagctg tgtacattta tcatggaagt ggcaagacta   4620

taaggaaaga gtatgcacaa cgtattccat caggtgggga tggtaagaca ctgaaatttt   4680

ttggccagtc tatccacgga gaaatggatt taaatggtga cggtctgaca gatgtgacta   4740

ttgggggcct tggtggtgct gccctcttct ggtcccgaga tgtggccgta gttaaagtga   4800

ccatgaattt tgagccaaat aaagtgaata ttcaaaagaa aaactgccat atggagggaa   4860

aggaaacagt atgcataaat gctacagtgt gttttgatgt gaaattaaag tctaaagaag   4920

acacgattta tgaagctgat ttgcagtacc gtgtcaccct agattcacta agacaaatat   4980

cacgaagttt tttctctgga actcaagaga gaaaggttca aaggaacatc acagttcgaa   5040

aatcagaatg cactaagcac tccttctaca tgttggcaag acaagcatga ctttcaggac   5100

tctgtgagaa taacgttgga ctttaatctt accgatccag aaaatgggcc tgttcttgat   5160

gattctctac caaactcagt acatgaatat attccctttg ccaaagattg tggaaataag   5220

gaaaaatgta tctcagacct cagcctgcat gtcgccacca ctgaaaagga cctgctgatt   5280

gtccgatccc agaatgataa gttcaacgtt agcctcacag tcaaaaatac aaaggacagt   5340

gcctataaca ccaggacaat agtgcattat tctccaaatc tagttttttc aggaattgag   5400

gctatccaaa aagacagttg tgaatctaat cataatatca catgtaaagt tggatatccc   5460

ttcctgagaa gaggagagat ggtaactttc aaaatattgt ttcagtttaa cacatcctat   5520

ctcatggaaa atgtgaccat ttatttaagt gcaacaagtg acagcgaaga acctcctgaa   5580

accctttctg ataatgtagt aaacatttct atcccggtaa aatatgaagt tggactacag   5640

ttttacagct ctgcaagtga ataccacatt tcaattgctg ccaatgagac agtccctgaa   5700

gttattaatt ctactgagga cattggaaat gaaattaata tcttctactt gattagaaaa   5760

agtggatctt ttccaatgcc agagcttaag ctgtcaattt cattccccaa tatgacatca   5820

aatggttacc ctgtgctgta cccaactgga ttgtcatctt ctgagaatgc aaactgcaga   5880

ccccatatct ttgaggatcc tttcagtatc aactctggaa agaaaatgac tacatcaact   5940

gaccatctca aacgaggcac aattctggac tgcaatacat gtaaatttgc taccatcaca   6000

tgtaatctca cttcttctga catcagccaa gtcaatgttt cgcttatctt gtggaaacca   6060

acttttataa aatcatattt ttccagctta aatcttacta taaggggaga acttcggagt   6120

gaaaatgcat ctctggtttt aagtagcagc aatcaaaaaa gagagcttgc tattcaaata   6180

tccaaagatg ggctaccggg cagagtgcca ttatgggtca tcctgctgag tgcttttgcc   6240

ggattgttgc tgttaatgct gctcatttta gcactgtgga agattggatt cttcaaaaga   6300

ccactgaaaa agaaaatgga gaaatgaaat attttatgaa agaaaataat aacaattatt   6360

caataatct                                                           6369


<210>  2723
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  2723

Met Glu Asp Gly Asn Ile Lys Ile Leu Gln Thr Leu Ser Gly Glu Gln 
1               5                   10                  15


Ile Gly Ser Tyr Phe Gly Ser Ile Leu Thr Thr Thr Asp Ile Asp Lys 
            20                  25                  30


Asp Ser Asn Thr Asp Ile Leu Leu Val Gly Ala Pro Met Tyr Met Gly 
        35                  40                  45


Thr Glu Lys Glu Glu Gln Gly Lys Val Tyr Val Tyr Ala Leu Asn Gln 
    50                  55                  60


Thr Arg Phe Glu Tyr Gln Met Ser Leu Glu Pro Ile Lys Gln Thr Cys 
65                  70                  75                  80


Cys Ser Ser Arg Gln His Asn Ser Cys Thr Thr Glu Asn Lys Asn Glu 
                85                  90                  95


Pro Cys Gly Ala Arg Phe Gly Thr Ala Ile Ala Ala Val Lys Asp Leu 
            100                 105                 110


Asn Leu Asp Gly Phe Asn Asp Ile Val Ile Gly Ala Pro Leu Glu Asp 
        115                 120                 125


Asp His Gly Gly Ala Val Tyr Ile Tyr His Gly Ser Gly Lys Thr Ile 
    130                 135                 140


Arg Lys Glu Tyr Ala Gln Arg Ile Pro Ser Gly Gly Asp Gly Lys Thr 
145                 150                 155                 160


Leu Lys Phe Phe Gly Gln Ser Ile His Gly Glu Met Asp Leu Asn Gly 
                165                 170                 175


Asp Gly Leu Thr Asp Val Thr Ile Gly Gly Leu Gly Gly Ala Ala Leu 
            180                 185                 190


Phe Trp Ser Arg Asp Val Ala Val Val Lys Val Thr Met Asn Phe Glu 
        195                 200                 205


Pro Asn Lys Val Asn Ile Gln Lys Lys Asn Cys His Met Glu Gly Lys 
    210                 215                 220


Glu Thr Val Cys Ile Asn Ala Thr Val Cys Phe Asp Val Lys Leu Lys 
225                 230                 235                 240


Ser Lys Glu Asp Thr Ile Tyr Glu Ala Asp Leu Gln Tyr Arg Val Thr 
                245                 250                 255


Leu Asp Ser Leu Arg Gln Ile Ser Arg Ser Phe Phe Ser Gly Thr Gln 
            260                 265                 270


Glu Arg Lys Val Gln Arg Asn Ile Thr Val Arg Lys Ser Glu Cys Thr 
        275                 280                 285


Lys His Ser Phe Tyr Met Leu Ala Arg Gln Ala 
    290                 295


<210>  2724
<211>  572
<212>  DNA
<213>  Homo sapiens

<400>  2724
gaaatattca gtctgtttca tcattgtgaa ataatagaat tattttaacc tcccttttgt     60

ttgcctatta tgggaattaa accaagatcc ccatcgatgg agaatgctga ccactgtcag    120

gtagacctca ggcaaaaaga aactgaagac tgaactcagg ctgttttaaa tttcttccca    180

aggagcctgg agacagtcac acctgcaggc gaccaatctt gctagactcg tcacactgac    240

ccagtctgtt gtgacttgct ctcatgactt gactctggca tagcaccact tgatgattaa    300

tagttttcct tatcttaaca aataaatgtt aacaccaagc cttaacatac ctttctgctg    360

accccaaggt tttagacaaa ggcttgttcc cttagccagt tgcaaatcag agaatctcta    420

aatccacctg ggacctgtta gcccctgctt caagatatcc tccctttgca gaacaagtca    480

atgtataacc tccacgtatt gatttatgag tttgcctatt acttctgttt tcctgaaatg    540

tacccctgtc tttaaaaacg cttgtaagcc ac                                  572


<210>  2725
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  2725

Ile Ser Ser Gln Gly Ala Trp Arg Gln Ser His Leu Gln Ala Thr Asn 
1               5                   10                  15


Leu Ala Arg Leu Val Thr Leu Thr Gln Ser Val Val Thr Cys Ser His 
            20                  25                  30


Asp Leu Thr Leu Ala 
        35


<210>  2726
<211>  2387
<212>  DNA
<213>  Homo sapiens

<400>  2726
gggaggtccc tgaggccgct gaggtcgttc gtgtctgttg aacggctgtg ggcgtcttgc     60

tgccttgggt agggggttaa aatcgttctt gagaggaacg tctctgtgcg aagagataat    120

gagtttagct ctgagaagtg agcttgtagt ggacaaaaca aagaggaaaa aaagaagaga    180

actgtctgag gaacagaaac aagaaattaa agatgctttt gaactatttg atacagacaa    240

agatgaagca atagattatc atgaattaaa ggtggcaatg agagccttgg ggtttgatgt    300

aaaaaaagct gatgtactga agattcttaa agattatgac agagaagcca cagggaaaat    360

cacctttgaa gattttaatg aagttgtgac agactggata ttggaaagag atccccatga    420

agaaatactc aaggcattta aactatttga tgatgatgat tcagttctta agaacatact    480

cttgcttcct atttggtcta gatgcctcag tctaaatcgg gagttcttca gtgaagtaaa    540

ccaagaggag ttcattgcta ttatgactgg tgacatttaa agaattacaa ggataaacac    600

taagaatgtt gcagttacca tcttatattc tatttttgtg cctggagcca tgtgaaaaaa    660

accaacttag ttcttttatc ctaaaggacc aaaaataagc atcttatata tctgtatttt    720

actactgtta agtttctttg tatgaactgt gttgttagta ctcagatagt ttagctttgt    780

atttataata gagcttttat ataaagtttt aaaaattgaa tgtgtgatat gtgttctttg    840

aaggtttttt aatttaacat ttatagtcac tttttagtgc acacattttc cagactttcg    900

ttaataaaat atttatttta ttagaatttt aaagtttggt aaatttgttt ttattcctag    960

tatctgttaa ccctcaagag tggatttctt aaatcttccc tttataattt tactagtttc   1020

tgaaacaaaa attgaaatac aattagcaat agagtggcac atttttccat tacctaacat   1080

ttcatcaatt ttgacattct atattttaat acaagctgac tcaatataag cctaattcct   1140

tttttaagag tcctgtcttt gagtttagaa ggaataagta ttgtgcagat agacccattt   1200

atccttgtgt attatgtttc ttaacttggt atcattgtaa gtatgaaagt taattttctt   1260

ctgaatattt ccttaaacaa attgaatgaa tacaatttga attttctaac ttcttgactg   1320

agagatttaa attttggaat tttgatttgt taaggtaatt atcactcaat tacatgtcac   1380

agtgatgaaa atagaaaact gtaagccaca gaaataattt aagtctatgt tttacctata   1440

tgaaggaaca gtctgtgatt caccaggaaa tagtagagac acagtttcca agtactggtg   1500

ggctcttctg ccttgtagaa gtgtatgtta gggggaaaca agtggttatg gagatcgatc   1560

atagaaaaaa atagtaccta tatggatcct tcactcatat ctagtactcg gtgttatggg   1620

ctctcccagg aacggaattg agttgtctat ttcagcaatc tttctttaga attcttgttt   1680

taaattttta agtttaaagt gtagtatcat ttgaggcgct ttaaatgttg tgagcctttt   1740

aagagtatta cattaagggt tgtccactag aaatttaaca caaaatcagt agggaatact   1800

atagcagtag tgacatttca aacagttatc taggaagcaa gtgtatatta agtcattctt   1860

gtattgctac gaagaaatac ccaagactgc atattttata aagaaaagaa gcttaattgg   1920

cttacggttc tgcaggcttt acaggaagca tggtgcttct gcttttgggg aggcctcagg   1980

aagcttacag tcatggtaga aggcaaaggg ggagcaggca catcacatgg tgaaaaccag   2040

agtgaacaag tgagagaagt gccaagtact ttgaaaccac cagatctcat gagaactcac   2100

tattgtgagg acatctaatc acctcccacc agacctcacc tccagtactg gggattacaa   2160

ttcaacatga tatttgagtg gggacagata tacaaactat atcagcaggt taactagagt   2220

aaaacttaat tttgaataca aattcaatgg tcacagtcat tatattcagg gcaacagacc   2280

ttgaaattaa aaaatttttg tcgcacactg atgagttccc tctgtcttga tcatgaaata   2340

tattgatttc caggaaagtg aaaaataaaa cagtaaaagt aaatcta                 2387


<210>  2727
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  2727

Met Ser Leu Ala Leu Arg Ser Glu Leu Val Val Asp Lys Thr Lys Arg 
1               5                   10                  15


Lys Lys Arg Arg Glu Leu Ser Glu Glu Gln Lys Gln Glu Ile Lys Asp 
            20                  25                  30


Ala Phe Glu Leu Phe Asp Thr Asp Lys Asp Glu Ala Ile Asp Tyr His 
        35                  40                  45


Glu Leu Lys Val Ala Met Arg Ala Leu Gly Phe Asp Val Lys Lys Ala 
    50                  55                  60


Asp Val Leu Lys Ile Leu Lys Asp Tyr Asp Arg Glu Ala Thr Gly Lys 
65                  70                  75                  80


Ile Thr Phe Glu Asp Phe Asn Glu Val Val Thr Asp Trp Ile Leu Glu 
                85                  90                  95


Arg Asp Pro His Glu Glu Ile Leu Lys Ala Phe Lys Leu Phe Asp Asp 
            100                 105                 110


Asp Asp Ser Val Leu Lys Asn Ile Leu Leu Leu Pro Ile Trp Ser Arg 
        115                 120                 125


Cys Leu Ser Leu Asn Arg Glu Phe Phe Ser Glu Val Asn Gln Glu Glu 
    130                 135                 140


Phe Ile Ala Ile Met Thr Gly Asp Ile 
145                 150


<210>  2728
<211>  2436
<212>  DNA
<213>  Homo sapiens

<400>  2728
atgttgtggg aggtccctga ggccgctgag gtcgttcgtg tctgttgaac ggctgtgggc     60

gtcttgctgc cttgggtagg gggttaaaat cgttcttgag aggaacgtct ctgtgcgaag    120

agataatgag tttagctctg agaagtgagc ttgtagtgga caaaacaaag aggaaaaaaa    180

gaagagaact gtctgaggaa cagaaacaag aaattaaaga tgcttttgaa ctatttgata    240

cagacaaaga tgaagcaata gattatcatg aattaaaggt ggcaatgaga gccttggggt    300

ttgatgtaaa aaaagctgat gtactgaaga ttcttaaaga ttatgacaga gaagccacag    360

ggaaaatcac ctttgaagat tttaatgaag ttgtgacaga ctggatattg gaaagagatc    420

cccatgaaga aatactcaag gcatttaaac tatttgatga tgatgattca ggtaaaataa    480

gcttgaggaa tttgcgacgt gttgctagag aattgggtga aaacatgagt gatgaagaac    540

ttcgagctat gatagaagaa tttgacaaag atggtgatgg agaaataaac caagaggagt    600

tcattgctat tatgactggt gacatttaaa gaattacaag gataaacact aagaatgttg    660

cagttaccat cttatattct atttttgtgc ctggagccat gtgaaaaaaa ccaacttagt    720

tcttttatcc taaaggacca aaaataagca tcttatatat ctgtatttta ctactgttaa    780

gtttctttgt atgaactgtg ttgttagtac tcagatagtt tagctttgta tttataatag    840

agcttttata taaagtttta aaaattgaat gtgtgatatg tgttctttga aggtttttta    900

atttaacatt tatagtcact ttttagtgca cacattttcc agactttcgt taataaaata    960

tttattttat tagaatttta aagtttggta aatttgtttt tattcctagt atctgttaac   1020

cctcaagagt ggatttctta aatcttccct ttataatttt actagtttct gaaacaaaaa   1080

ttgaaataca attagcaata gagtggcaca tttttccatt acctaacatt tcatcaattt   1140

tgacattcta tattttaata caagctgact caatataagc ctaattcctt ttttaagagt   1200

cctgtctttg agtttagaag gaataagtat tgtgcagata gacccattta tccttgtgta   1260

ttatgtttct taacttggta tcattgtaag tatgaaagtt aattttcttc tgaatatttc   1320

cttaaacaaa ttgaatgaat acaatttgaa ttttctaact tcttgactga gagatttaaa   1380

ttttggaatt ttgatttgtt aaggtaatta tcactcaatt acatgtcaca gtgatgaaaa   1440

tagaaaactg taagccacag aaataattta agtctatgtt ttacctatat gaaggaacag   1500

tctgtgattc accaggaaat agtagagaca cagtttccaa gtactggtgg gctcttctgc   1560

cttgtagaag tgtatgttag ggggaaacaa gtggttatgg agatcgatca tagaaaaaaa   1620

tagtacctat atggatcctt cactcatatc tagtactcgg tgttatgggc tctcccagga   1680

acggaattga gttgtctatt tcagcaatct ttctttagaa ttcttgtttt aaatttttaa   1740

gtttaaagtg tagtatcatt tgaggcgctt taaatgttgt gagcctttta agagtattac   1800

attaagggtt gtccactaga aatttaacac aaaatcagta gggaatacta tagcagtagt   1860

gacatttcaa acagttatct aggaagcaag tgtatattaa gtcattcttg tattgctacg   1920

aagaaatacc caagactgca tattttataa agaaaagaag cttaattggc ttacggttct   1980

gcaggcttta caggaagcat ggtgcttctg cttttgggga ggcctcagga agcttacagt   2040

catggtagaa ggcaaagggg gagcaggcac atcacatggt gaaaaccaga gtgaacaagt   2100

gagagaagtg ccaagtactt tgaaaccacc agatctcatg agaactcact attgtgagga   2160

catctaatca cctcccacca gacctcacct ccagtactgg ggattacaat tcaacatgat   2220

atttgagtgg ggacagatat acaaactata tcagcaggtt aactagagta aaacttaatt   2280

ttgaatacaa attcaatggt cacagtcatt atattcaggg caacagacct tgaaattaaa   2340

aaatttttgt cgcacactga tgagttccct ctgtcttgat catgaaatat attgatttcc   2400

aggaaagtga aaaataaaac agtaaaagta aatcta                             2436


<210>  2729
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  2729

Met Ser Leu Ala Leu Arg Ser Glu Leu Val Val Asp Lys Thr Lys Arg 
1               5                   10                  15


Lys Lys Arg Arg Glu Leu Ser Glu Glu Gln Lys Gln Glu Ile Lys Asp 
            20                  25                  30


Ala Phe Glu Leu Phe Asp Thr Asp Lys Asp Glu Ala Ile Asp Tyr His 
        35                  40                  45


Glu Leu Lys Val Ala Met Arg Ala Leu Gly Phe Asp Val Lys Lys Ala 
    50                  55                  60


Asp Val Leu Lys Ile Leu Lys Asp Tyr Asp Arg Glu Ala Thr Gly Lys 
65                  70                  75                  80


Ile Thr Phe Glu Asp Phe Asn Glu Val Val Thr Asp Trp Ile Leu Glu 
                85                  90                  95


Arg Asp Pro His Glu Glu Ile Leu Lys Ala Phe Lys Leu Phe Asp Asp 
            100                 105                 110


Asp Asp Ser Gly Lys Ile Ser Leu Arg Asn Leu Arg Arg Val Ala Arg 
        115                 120                 125


Glu Leu Gly Glu Asn Met Ser Asp Glu Glu Leu Arg Ala Met Ile Glu 
    130                 135                 140


Glu Phe Asp Lys Asp Gly Asp Gly Glu Ile Asn Gln Glu Glu Phe Ile 
145                 150                 155                 160


Ala Ile Met Thr Gly Asp Ile 
                165


<210>  2730
<211>  2508
<212>  DNA
<213>  Homo sapiens

<400>  2730
atgttgtggg aggtccctga ggccgctgag gtcgttcgtg tctgttgaac ggctgtgggc     60

gtcttgctgc cttgggtagg gggttaaaat cgttcttgag aggaacgtct ctgtgcgaag    120

agataatgag tttagctctg agaagtgagc ttgtagtgga caaaacaaag aggaaaaaaa    180

gaagagaact gtctgaggaa cagaaacaag aaattaaaga tgcttttgaa ctatttgata    240

cagacaaaga tgaagcaata gattatcatg aattaaaggt ggcaatgaga gccttggggt    300

ttgatgtaaa aaaagctgat gtactgaaga ttcttaaaga ttatgacaga gaagccacag    360

ggaaaatcac ctttgaagat tttaatgaag ttgtgacaga ctggatattg gaaagagatc    420

cccatgaaga aatactcaag gcatttaaac tatttgatga tgatgattca ggtaaaataa    480

gcttgaggaa tttgcgacgt gttgctagag aattgggtga aaacatgagt gatgaagaac    540

ttcgagctat gatagaagaa tttgacaaag atggtgatgg agaaattctt aagaacatac    600

tcttgcttcc tatttggtct agatgcctca gtctaaatcg ggagttcttc agtgaagtaa    660

accaagagga gttcattgct attatgactg gtgacattta aagaattaca aggataaaca    720

ctaagaatgt tgcagttacc atcttatatt ctatttttgt gcctggagcc atgtgaaaaa    780

aaccaactta gttcttttat cctaaaggac caaaaataag catcttatat atctgtattt    840

tactactgtt aagtttcttt gtatgaactg tgttgttagt actcagatag tttagctttg    900

tatttataat agagctttta tataaagttt taaaaattga atgtgtgata tgtgttcttt    960

gaaggttttt taatttaaca tttatagtca ctttttagtg cacacatttt ccagactttc   1020

gttaataaaa tatttatttt attagaattt taaagtttgg taaatttgtt tttattccta   1080

gtatctgtta accctcaaga gtggatttct taaatcttcc ctttataatt ttactagttt   1140

ctgaaacaaa aattgaaata caattagcaa tagagtggca catttttcca ttacctaaca   1200

tttcatcaat tttgacattc tatattttaa tacaagctga ctcaatataa gcctaattcc   1260

ttttttaaga gtcctgtctt tgagtttaga aggaataagt attgtgcaga tagacccatt   1320

tatccttgtg tattatgttt cttaacttgg tatcattgta agtatgaaag ttaattttct   1380

tctgaatatt tccttaaaca aattgaatga atacaatttg aattttctaa cttcttgact   1440

gagagattta aattttggaa ttttgatttg ttaaggtaat tatcactcaa ttacatgtca   1500

cagtgatgaa aatagaaaac tgtaagccac agaaataatt taagtctatg ttttacctat   1560

atgaaggaac agtctgtgat tcaccaggaa atagtagaga cacagtttcc aagtactggt   1620

gggctcttct gccttgtaga agtgtatgtt agggggaaac aagtggttat ggagatcgat   1680

catagaaaaa aatagtacct atatggatcc ttcactcata tctagtactc ggtgttatgg   1740

gctctcccag gaacggaatt gagttgtcta tttcagcaat ctttctttag aattcttgtt   1800

ttaaattttt aagtttaaag tgtagtatca tttgaggcgc tttaaatgtt gtgagccttt   1860

taagagtatt acattaaggg ttgtccacta gaaatttaac acaaaatcag tagggaatac   1920

tatagcagta gtgacatttc aaacagttat ctaggaagca agtgtatatt aagtcattct   1980

tgtattgcta cgaagaaata cccaagactg catattttat aaagaaaaga agcttaattg   2040

gcttacggtt ctgcaggctt tacaggaagc atggtgcttc tgcttttggg gaggcctcag   2100

gaagcttaca gtcatggtag aaggcaaagg gggagcaggc acatcacatg gtgaaaacca   2160

gagtgaacaa gtgagagaag tgccaagtac tttgaaacca ccagatctca tgagaactca   2220

ctattgtgag gacatctaat cacctcccac cagacctcac ctccagtact ggggattaca   2280

attcaacatg atatttgagt ggggacagat atacaaacta tatcagcagg ttaactagag   2340

taaaacttaa ttttgaatac aaattcaatg gtcacagtca ttatattcag ggcaacagac   2400

cttgaaatta aaaaattttt gtcgcacact gatgagttcc ctctgtcttg atcatgaaat   2460

atattgattt ccaggaaagt gaaaaataaa acagtaaaag taaatcta                2508


<210>  2731
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  2731

Met Ser Leu Ala Leu Arg Ser Glu Leu Val Val Asp Lys Thr Lys Arg 
1               5                   10                  15


Lys Lys Arg Arg Glu Leu Ser Glu Glu Gln Lys Gln Glu Ile Lys Asp 
            20                  25                  30


Ala Phe Glu Leu Phe Asp Thr Asp Lys Asp Glu Ala Ile Asp Tyr His 
        35                  40                  45


Glu Leu Lys Val Ala Met Arg Ala Leu Gly Phe Asp Val Lys Lys Ala 
    50                  55                  60


Asp Val Leu Lys Ile Leu Lys Asp Tyr Asp Arg Glu Ala Thr Gly Lys 
65                  70                  75                  80


Ile Thr Phe Glu Asp Phe Asn Glu Val Val Thr Asp Trp Ile Leu Glu 
                85                  90                  95


Arg Asp Pro His Glu Glu Ile Leu Lys Ala Phe Lys Leu Phe Asp Asp 
            100                 105                 110


Asp Asp Ser Gly Lys Ile Ser Leu Arg Asn Leu Arg Arg Val Ala Arg 
        115                 120                 125


Glu Leu Gly Glu Asn Met Ser Asp Glu Glu Leu Arg Ala Met Ile Glu 
    130                 135                 140


Glu Phe Asp Lys Asp Gly Asp Gly Glu Ile Leu Lys Asn Ile Leu Leu 
145                 150                 155                 160


Leu Pro Ile Trp Ser Arg Cys Leu Ser Leu Asn Arg Glu Phe Phe Ser 
                165                 170                 175


Glu Val Asn Gln Glu Glu Phe Ile Ala Ile Met Thr Gly Asp Ile 
            180                 185                 190


<210>  2732
<211>  930
<212>  DNA
<213>  Homo sapiens

<400>  2732
gggaggtccc tgaggccgct gaggtcgttc gtgtctgttg aacggctgtg ggcgtcttgc     60

tgccttgggt agggggttaa aatcgttctt gagaggaacg tctctgtgcg aagagataat    120

gagtttagct ctgagaagtg agcttgtagt ggacaaaaca aagaggaaaa aaagaagaga    180

actgtctgag gaacagaaac aagaaattaa agatgctttt gaactatttg atacagacaa    240

agatgaagca atagattatc atgaattaaa ggtggcaatg agagccttgg ggtttgatgt    300

aaaaaaagct gatgtactga agattcttaa agattatgac agagaagcca cagggaaaat    360

cacctttgaa gattttaatg aagttgtgac agactggata ttggaaagag atccccatga    420

agaaatactc aaggcattta aactatttga tgatgatgat tcagttctta agaacatact    480

cttgcttcct atttggtcta gatgcctcag tctaaatcgg gagttcttca gtgaagtaaa    540

ccaagaggag ttcattgcta ttatgactgg tgacatttaa agaattacaa ggataaacac    600

taagaatgtt gcagttacca tcttatattc tatttttgtg cctggagcca tgtgaaaaaa    660

accaacttag ttcttttatc ctaaaggacc aaaaataagc atcttatata tctgtatttt    720

actactgtta agtttctttg tatgaactgt gttgttagta ctcagatagt ttagctttgt    780

atttataata gagcttttat ataaagtttt aaaaattgaa tgtgtgatat gtgttctttg    840

aaggtttttt aatttaacat ttatagtcac tttttagtgc acacattttc cagactttcg    900

ttaataaaat atttatttta ttagaatttt                                     930


<210>  2733
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  2733

Met Ser Leu Ala Leu Arg Ser Glu Leu Val Val Asp Lys Thr Lys Arg 
1               5                   10                  15


Lys Lys Arg Arg Glu Leu Ser Glu Glu Gln Lys Gln Glu Ile Lys Asp 
            20                  25                  30


Ala Phe Glu Leu Phe Asp Thr Asp Lys Asp Glu Ala Ile Asp Tyr His 
        35                  40                  45


Glu Leu Lys Val Ala Met Arg Ala Leu Gly Phe Asp Val Lys Lys Ala 
    50                  55                  60


Asp Val Leu Lys Ile Leu Lys Asp Tyr Asp Arg Glu Ala Thr Gly Lys 
65                  70                  75                  80


Ile Thr Phe Glu Asp Phe Asn Glu Val Val Thr Asp Trp Ile Leu Glu 
                85                  90                  95


Arg Asp Pro His Glu Glu Ile Leu Lys Ala Phe Lys Leu Phe Asp Asp 
            100                 105                 110


Asp Asp Ser Val Leu Lys Asn Ile Leu Leu Leu Pro Ile Trp Ser Arg 
        115                 120                 125


Cys Leu Ser Leu Asn Arg Glu Phe Phe Ser Glu Val Asn Gln Glu Glu 
    130                 135                 140


Phe Ile Ala Ile Met Thr Gly Asp Ile 
145                 150


<210>  2734
<211>  979
<212>  DNA
<213>  Homo sapiens

<400>  2734
atgttgtggg aggtccctga ggccgctgag gtcgttcgtg tctgttgaac ggctgtgggc     60

gtcttgctgc cttgggtagg gggttaaaat cgttcttgag aggaacgtct ctgtgcgaag    120

agataatgag tttagctctg agaagtgagc ttgtagtgga caaaacaaag aggaaaaaaa    180

gaagagaact gtctgaggaa cagaaacaag aaattaaaga tgcttttgaa ctatttgata    240

cagacaaaga tgaagcaata gattatcatg aattaaaggt ggcaatgaga gccttggggt    300

ttgatgtaaa aaaagctgat gtactgaaga ttcttaaaga ttatgacaga gaagccacag    360

ggaaaatcac ctttgaagat tttaatgaag ttgtgacaga ctggatattg gaaagagatc    420

cccatgaaga aatactcaag gcatttaaac tatttgatga tgatgattca ggtaaaataa    480

gcttgaggaa tttgcgacgt gttgctagag aattgggtga aaacatgagt gatgaagaac    540

ttcgagctat gatagaagaa tttgacaaag atggtgatgg agaaataaac caagaggagt    600

tcattgctat tatgactggt gacatttaaa gaattacaag gataaacact aagaatgttg    660

cagttaccat cttatattct atttttgtgc ctggagccat gtgaaaaaaa ccaacttagt    720

tcttttatcc taaaggacca aaaataagca tcttatatat ctgtatttta ctactgttaa    780

gtttctttgt atgaactgtg ttgttagtac tcagatagtt tagctttgta tttataatag    840

agcttttata taaagtttta aaaattgaat gtgtgatatg tgttctttga aggtttttta    900

atttaacatt tatagtcact ttttagtgca cacattttcc agactttcgt taataaaata    960

tttattttat tagaatttt                                                 979


<210>  2735
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  2735

Met Ser Leu Ala Leu Arg Ser Glu Leu Val Val Asp Lys Thr Lys Arg 
1               5                   10                  15


Lys Lys Arg Arg Glu Leu Ser Glu Glu Gln Lys Gln Glu Ile Lys Asp 
            20                  25                  30


Ala Phe Glu Leu Phe Asp Thr Asp Lys Asp Glu Ala Ile Asp Tyr His 
        35                  40                  45


Glu Leu Lys Val Ala Met Arg Ala Leu Gly Phe Asp Val Lys Lys Ala 
    50                  55                  60


Asp Val Leu Lys Ile Leu Lys Asp Tyr Asp Arg Glu Ala Thr Gly Lys 
65                  70                  75                  80


Ile Thr Phe Glu Asp Phe Asn Glu Val Val Thr Asp Trp Ile Leu Glu 
                85                  90                  95


Arg Asp Pro His Glu Glu Ile Leu Lys Ala Phe Lys Leu Phe Asp Asp 
            100                 105                 110


Asp Asp Ser Gly Lys Ile Ser Leu Arg Asn Leu Arg Arg Val Ala Arg 
        115                 120                 125


Glu Leu Gly Glu Asn Met Ser Asp Glu Glu Leu Arg Ala Met Ile Glu 
    130                 135                 140


Glu Phe Asp Lys Asp Gly Asp Gly Glu Ile Asn Gln Glu Glu Phe Ile 
145                 150                 155                 160


Ala Ile Met Thr Gly Asp Ile 
                165


<210>  2736
<211>  1051
<212>  DNA
<213>  Homo sapiens

<400>  2736
atgttgtggg aggtccctga ggccgctgag gtcgttcgtg tctgttgaac ggctgtgggc     60

gtcttgctgc cttgggtagg gggttaaaat cgttcttgag aggaacgtct ctgtgcgaag    120

agataatgag tttagctctg agaagtgagc ttgtagtgga caaaacaaag aggaaaaaaa    180

gaagagaact gtctgaggaa cagaaacaag aaattaaaga tgcttttgaa ctatttgata    240

cagacaaaga tgaagcaata gattatcatg aattaaaggt ggcaatgaga gccttggggt    300

ttgatgtaaa aaaagctgat gtactgaaga ttcttaaaga ttatgacaga gaagccacag    360

ggaaaatcac ctttgaagat tttaatgaag ttgtgacaga ctggatattg gaaagagatc    420

cccatgaaga aatactcaag gcatttaaac tatttgatga tgatgattca ggtaaaataa    480

gcttgaggaa tttgcgacgt gttgctagag aattgggtga aaacatgagt gatgaagaac    540

ttcgagctat gatagaagaa tttgacaaag atggtgatgg agaaattctt aagaacatac    600

tcttgcttcc tatttggtct agatgcctca gtctaaatcg ggagttcttc agtgaagtaa    660

accaagagga gttcattgct attatgactg gtgacattta aagaattaca aggataaaca    720

ctaagaatgt tgcagttacc atcttatatt ctatttttgt gcctggagcc atgtgaaaaa    780

aaccaactta gttcttttat cctaaaggac caaaaataag catcttatat atctgtattt    840

tactactgtt aagtttcttt gtatgaactg tgttgttagt actcagatag tttagctttg    900

tatttataat agagctttta tataaagttt taaaaattga atgtgtgata tgtgttcttt    960

gaaggttttt taatttaaca tttatagtca ctttttagtg cacacatttt ccagactttc   1020

gttaataaaa tatttatttt attagaattt t                                  1051


<210>  2737
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  2737

Met Ser Leu Ala Leu Arg Ser Glu Leu Val Val Asp Lys Thr Lys Arg 
1               5                   10                  15


Lys Lys Arg Arg Glu Leu Ser Glu Glu Gln Lys Gln Glu Ile Lys Asp 
            20                  25                  30


Ala Phe Glu Leu Phe Asp Thr Asp Lys Asp Glu Ala Ile Asp Tyr His 
        35                  40                  45


Glu Leu Lys Val Ala Met Arg Ala Leu Gly Phe Asp Val Lys Lys Ala 
    50                  55                  60


Asp Val Leu Lys Ile Leu Lys Asp Tyr Asp Arg Glu Ala Thr Gly Lys 
65                  70                  75                  80


Ile Thr Phe Glu Asp Phe Asn Glu Val Val Thr Asp Trp Ile Leu Glu 
                85                  90                  95


Arg Asp Pro His Glu Glu Ile Leu Lys Ala Phe Lys Leu Phe Asp Asp 
            100                 105                 110


Asp Asp Ser Gly Lys Ile Ser Leu Arg Asn Leu Arg Arg Val Ala Arg 
        115                 120                 125


Glu Leu Gly Glu Asn Met Ser Asp Glu Glu Leu Arg Ala Met Ile Glu 
    130                 135                 140


Glu Phe Asp Lys Asp Gly Asp Gly Glu Ile Leu Lys Asn Ile Leu Leu 
145                 150                 155                 160


Leu Pro Ile Trp Ser Arg Cys Leu Ser Leu Asn Arg Glu Phe Phe Ser 
                165                 170                 175


Glu Val Asn Gln Glu Glu Phe Ile Ala Ile Met Thr Gly Asp Ile 
            180                 185                 190


<210>  2738
<211>  875
<212>  DNA
<213>  Homo sapiens

<400>  2738
atgttgtggg aggtccctga ggccgctgag gtcgttcgtg tctgttgaac ggctgtgggc     60

gtcttgctgc cttgggtagg gggttaaaat cgttcttgag aggaacgtct ctgtgcgaag    120

agataatgag tttagctctg agaagtgagc ttgtagtgga caaaacaaag aggaaaaaaa    180

gaagagaact gtctgaggaa cagaaacaag aaattaaaga tgcttttgaa ctatttgata    240

cagacaaaga tgaagcaata gattatcatg aattaaaggt ggcaatgaga gccttggggt    300

ttgatgtaaa aaaagctgat gtactgaaga ttcttaaaga ttatgacaga gaagccacag    360

ggaaaatcac ctttgaagat tttaatgaag ttgtgacaga ctggatattg gaaagagatc    420

cccatgaaga aatactcaag gcatttaaac tatttgatga tgatgattca ggtaaaataa    480

gcttgaggaa tttgcgacgt gttgctagag aattgggtga aaacatgagt gatgaagaac    540

ttcgagctat gatagaagaa tttgacaaag atggtgatgg agaaataaac caagaggagt    600

tcattgctat tatgactggt gacatttaaa gaattacaag gataaacact aagaatgttg    660

cagttaccat cttatattct atttttgtgc ctggagccat gtgaaaaaaa ccaacttagt    720

tcttttatcc taaaggacca aaaataagca tcttatatat ctgtatttta ctactgttaa    780

gtttctttgt atgaactgtg ttgttagtac tcagatagtt tagctttgta tttataatag    840

agcttttata taaagtttta aaaattgaat gtgtg                               875


<210>  2739
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  2739

Met Ser Leu Ala Leu Arg Ser Glu Leu Val Val Asp Lys Thr Lys Arg 
1               5                   10                  15


Lys Lys Arg Arg Glu Leu Ser Glu Glu Gln Lys Gln Glu Ile Lys Asp 
            20                  25                  30


Ala Phe Glu Leu Phe Asp Thr Asp Lys Asp Glu Ala Ile Asp Tyr His 
        35                  40                  45


Glu Leu Lys Val Ala Met Arg Ala Leu Gly Phe Asp Val Lys Lys Ala 
    50                  55                  60


Asp Val Leu Lys Ile Leu Lys Asp Tyr Asp Arg Glu Ala Thr Gly Lys 
65                  70                  75                  80


Ile Thr Phe Glu Asp Phe Asn Glu Val Val Thr Asp Trp Ile Leu Glu 
                85                  90                  95


Arg Asp Pro His Glu Glu Ile Leu Lys Ala Phe Lys Leu Phe Asp Asp 
            100                 105                 110


Asp Asp Ser Gly Lys Ile Ser Leu Arg Asn Leu Arg Arg Val Ala Arg 
        115                 120                 125


Glu Leu Gly Glu Asn Met Ser Asp Glu Glu Leu Arg Ala Met Ile Glu 
    130                 135                 140


Glu Phe Asp Lys Asp Gly Asp Gly Glu Ile Asn Gln Glu Glu Phe Ile 
145                 150                 155                 160


Ala Ile Met Thr Gly Asp Ile 
                165


<210>  2740
<211>  1528
<212>  DNA
<213>  Homo sapiens

<400>  2740
gggaggtccc tgaggccgct gaggtcgttc gtgtctgttg aacggctgtg ggcgtcttgc     60

tgccttgggt agggggttaa aatcgttctt gagaggaacg tctctgtgcg aagagataat    120

gagtttagct ctgagaagtg agcttgtagt ggacaaaaca aagaggaaaa aaagaagaga    180

actgtctgag gaacagaaac aagaaattaa agatgctttt gaactatttg atacagacaa    240

agatgaagca atagattatc atgaattaaa ggtggcaatg agagccttgg ggtttgatgt    300

aaaaaaagct gatgtactga agattcttaa agattatgac agagaagcca cagggaaaat    360

cacctttgaa gattttaatg aagttgtgac agactggata ttggaaagag atccccatga    420

agaaatactc aaggcattta aactatttga tgatgatgat tcaggtaaaa taagcttgag    480

gaatttgcga cgtgttgcta gagaattggg tgaaaacatg agtgatgaag aacttcgagc    540

tatgatagaa gaatttgaca aagatggtga tggagaaagt aagttttaag tgaaacgtat    600

tttccaggtt ttcctgatgc tacacatgta atacattttt ctaaaaccaa atgacttgca    660

agactttttt gtaaacttaa ctgcttcttg taatggacct tctgtctaaa taattcacat    720

attcaattta gaatgaagca gatctctaaa accaattata cttcaagaag gtccttcact    780

tttctctgaa ggtgaaacca ccaaaatttc agcctttcaa tataatttca gtctttaatg    840

gcttctccct caacctacat gctaagttct aagttctatt gattttcccc ttcaaatgtt    900

ttgaatctgt ttttatcttt gtccattgtg gctgtcctag ttcaggccct aatttctagt    960

taggaatgtt ataatggcct catttattct tgccttggct gcctactggg tgcagtgtcc   1020

tgcgtgttga ctggtgctac acaatgaaaa aggcagatgt ggttcttgct ttcactttgc   1080

agtctcttgt agtgtcctaa ttgccctttc ggcatataaa agtctctaat ctcttcttca   1140

gtctcttggt atcattcttt tcctaaaata tacatttgat aatgccattt ctgtgtttag   1200

acacttgaaa cgattcttca gtgcctacag agtaaagttc aaagccttct atgatctatc   1260

ccaccttgag taactgattt tactttccag tgtattcttt cacttttctt ctttaaccct   1320

cacctcctgt atgtacacat tttgtcaaca tatgctatcc tgaaaacaca tttttatgct   1380

attcgtttca tcctgctgtt tcttaatctt agaatgctct aattgttaat ttctgcctgc   1440

taaaatgtga ttcattctct caggtaaata ttaaacacca tctttttccc aaaagcttcc   1500

cataacgctc tatgaatcat gagacttc                                      1528


<210>  2741
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  2741

Met Ser Leu Ala Leu Arg Ser Glu Leu Val Val Asp Lys Thr Lys Arg 
1               5                   10                  15


Lys Lys Arg Arg Glu Leu Ser Glu Glu Gln Lys Gln Glu Ile Lys Asp 
            20                  25                  30


Ala Phe Glu Leu Phe Asp Thr Asp Lys Asp Glu Ala Ile Asp Tyr His 
        35                  40                  45


Glu Leu Lys Val Ala Met Arg Ala Leu Gly Phe Asp Val Lys Lys Ala 
    50                  55                  60


Asp Val Leu Lys Ile Leu Lys Asp Tyr Asp Arg Glu Ala Thr Gly Lys 
65                  70                  75                  80


Ile Thr Phe Glu Asp Phe Asn Glu Val Val Thr Asp Trp Ile Leu Glu 
                85                  90                  95


Arg Asp Pro His Glu Glu Ile Leu Lys Ala Phe Lys Leu Phe Asp Asp 
            100                 105                 110


Asp Asp Ser Gly Lys Ile Ser Leu Arg Asn Leu Arg Arg Val Ala Arg 
        115                 120                 125


Glu Leu Gly Glu Asn Met Ser Asp Glu Glu Leu Arg Ala Met Ile Glu 
    130                 135                 140


Glu Phe Asp Lys Asp Gly Asp Gly Glu Ser Lys Phe 
145                 150                 155


<210>  2742
<211>  794
<212>  DNA
<213>  Homo sapiens

<400>  2742
gggaggtccc tgaggccgct gaggtcgttc gtgtctgttg aacggctgtg ggcgtcttgc     60

tgccttgggt agggggttaa aatcgttctt gagaggaacg tctctgtgcg aagagataat    120

gagtttagct ctgagaagtg agcttgtagt ggacaaaaca aagaggaaaa aaagaagaga    180

actgtctgag gaacagaaac aagaaattaa agatgctttt gaactatttg atacagacaa    240

agatgaagca atagattatc atgaattaaa ggtggcaatg agagccttgg ggtttgatgt    300

aaaaaaagct gatgtactga agattcttaa agattatgac agagaagcca cagggaaaat    360

cacctttgaa gattttaatg aagttggtgt gtattttaat agtctttgta atcagcagct    420

gttaggaaat tgtctgatta atatcacttt ttaaatttta aattctctag gttatggaat    480

tttcttatag aacactggtg tataatgtga ctcttactca gttttgtttt gttggttttt    540

ttttcaaaga aaaaatatgg ctttgctctg agatttatag ttttgtcttt tgttttgttg    600

tgaagattct aaccaaggaa ctattgtgta gctttttata gaaagatgct tttccaagtt    660

gtttgtattt atattatgtg ataaaacttg aagggtgatc aaaaaattat ttttgcttaa    720

taaaacagaa aatttgatat cctgctgttt ggaaaatgtt tcccaagacc tttctggtat    780

gtgatttttg ttgg                                                      794


<210>  2743
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  2743

Met Ser Leu Ala Leu Arg Ser Glu Leu Val Val Asp Lys Thr Lys Arg 
1               5                   10                  15


Lys Lys Arg Arg Glu Leu Ser Glu Glu Gln Lys Gln Glu Ile Lys Asp 
            20                  25                  30


Ala Phe Glu Leu Phe Asp Thr Asp Lys Asp Glu Ala Ile Asp Tyr His 
        35                  40                  45


Glu Leu Lys Val Ala Met Arg Ala Leu Gly Phe Asp Val Lys Lys Ala 
    50                  55                  60


Asp Val Leu Lys Ile Leu Lys Asp Tyr Asp Arg Glu Ala Thr Gly Lys 
65                  70                  75                  80


Ile Thr Phe Glu Asp Phe Asn Glu Val Gly Val Tyr Phe Asn Ser Leu 
                85                  90                  95


Cys Asn Gln Gln Leu Leu Gly Asn Cys Leu Ile Asn Ile Thr Phe 
            100                 105                 110


<210>  2744
<211>  441
<212>  DNA
<213>  Homo sapiens

<400>  2744
gtggctgttt ggcgggtggg cgctgtgttc ctctctcgta aagccgtgcg gtctgtgggc     60

cgccattcag aaactggatg gacagcttcg gcggtgggaa gggaagggac atgctgcagg    120

ccaccctccg gctagaagga gggagtactt gaggaacaag gtctgcgaaa attggctgtg    180

ctctgttcta aaacttggaa tggcctcagt acctggggaa tgtgtttaaa atgcagactt    240

aaatgtccgt ttctccattc taatttcagt agtgctgtaa gctgttaaca cacatgagac    300

tgtcttcact accaaaccaa gtctcctaaa gctcacttga atgtctgctt attcgtgtct    360

cttactaggt tcaatttctt ggaggccgtg attatatcta tttaacgctt ttccttgtac    420

ctaataaaat gtctggtgcg t                                              441


<210>  2745
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  2745

Val Ala Val Trp Arg Val Gly Ala Val Phe Leu Ser Arg Lys Ala Val 
1               5                   10                  15


Arg Ser Val Gly Arg His Ser Glu Thr Gly Trp Thr Ala Ser Ala Val 
            20                  25                  30


Gly Arg Glu Gly Thr Cys Cys Arg Pro Pro Ser Gly 
        35                  40


<210>  2746
<211>  3691
<212>  DNA
<213>  Homo sapiens

<400>  2746
agaccgcttc acacagccgc agtgccctgt gtgtggacag cctgtgggag actcgcacgc     60

ccacactcac cccgcctggc tgcacccctg cccagcatgt gcggcgcgcc ggccactgct    120

tgccgtggcc acccacgtgc acttcgacca ctccggcggc ctctaccagt tcgaccgcgt    180

ggcagtgcac cacgccgagg ccgaggcgct ggctcgcggg gacaactttg agaccgtgac    240

ctggctttcc gatagcgagg tggtgcggac gcccagcccc ggctggaggg ccagacagtt    300

ccgggtacag gcggtgcagc ccaccctcat cctgcaggat ggggatgtga tcaaccttgg    360

tgacagacag ctcactgtta tgcacatgcc aggtcactcc aggggcagta tttgcttaca    420

tgacaaagac cgaaagattc tcttcagtgg agacgtcgtg tatgatggat cactgattga    480

ctggctccca tacagcagga taagtgacta tgttggaact tgtgaacgtc taatagaatt    540

agtggacaga ggtctggtag agaaggtgct tcctgggcac ttcaatacct ttggtgctga    600

aaggcttttt cgattggctt ctaactatat ttcaaaagct gggatatgtc acaaagtttc    660

tacttttgcc atgcgatctc ttgcaagttt agctctacgt gtaacaaatt ctaggacctc    720

gccctagtat ctatactgat aatatatttt gattaattat atacattaat tcattctgtg    780

ctatttaact gattaatagt gagcatttca tgaagtgctt ttataccact attatatatc    840

agagaaagat tgagaatgaa taagccaaaa agaaaattgt tagtttaaat tgttttcttt    900

cttccaagaa agaagccact taaataagct tatactttgc caaagctgtc atcttgtaat    960

atatgctcta gaaatgacat aaaggtttat ggggaagcaa agagagattt tgtggcaaga   1020

gaactgccct tgcctctgtt tttcttgttt tattcccttg atgacctagg gaaaaaaagg   1080

catgtagagt attatgttta tactttaaac ttgatatttt tagtgtatta tttaaagata   1140

aaggttcttg ggtttaaaat acattagaac ttaatgcaga catataaagt aacattgaga   1200

atgacaacta aaacattcca ttgttatggt cctgaatttt ttatgcttca tttcatgtat   1260

ttattctttg tataattata gcatacatgt tatgtaatat aacttatgaa aagtacagtg   1320

aattttgctt tattgcaaag ctttaaatat aaatttcaga gtgcttcagt aaaaagctac   1380

tatatattgt tgtttgttat tgtgtaggta atattttcaa ttatgaaagt gaaatgcaaa   1440

tgtctgttat ctaactacaa attgtcagat ttcttaaaag gacactgtca ggcaaatttg   1500

aaaatataca cattgagaat aattttttat tattatatcc tattttaata ttaacagcta   1560

ttatgaacaa aatttttcct gttaaatagc gacttcagta ttgtgttatg ttttacagcg   1620

ttaaaacaac tatgaagatc tgcagctatt cttttactta acatgcatat gtactacaga   1680

gggattttta aattaattgc aaaatgtgca ttagctattg acttagagtg aattgccttt   1740

tgtatcctga ttcacaacac ctattcctgt tcagtattct ttgtcttgaa tagagaagtc   1800

tatgttcgta aagtcatata aaaggttata ccactattta gtaaaaagtt ttagtttggt   1860

gctgttaata ataatttgct aaaaggcctt ttagaatatt tcataaaggg ttttaaacag   1920

ttttttccca ctgccttttt attattgaca tatctaaaac caaactgaaa tcgctttgga   1980

aatcagattt tttaatgtta ggaagatcca gcaattttgg tttctgaaaa attacaaaac   2040

ttttctaccc tacagatgcc caggttcttt agttttttat tcattcaact cacacacaca   2100

taaacatata catacacaaa cacaatccca catgcaaaca cacacagcca catatataca   2160

tgtgtagcac agcgctaaac actgtggagg ctaaaaaaag tcaaagacaa cattataact   2220

aaaagtcgaa agcacacaaa atataaataa tagtgtatgc aagttaatgt acattataca   2280

tgcgtgtaag ggacataaat ggaggggtgt gaactttggt taggcaaagt ttactggagg   2340

aggggttttt gagtcaaatt tggaaggatg aacttgttag atagtcagag ttggaaacaa   2400

aacaatccaa gaatagggat ataagcattg ctagtctaga atagtctatt ccttgtgaaa   2460

atataaattt aattttcagg aatccagtat attccaaaca tcacatattt agcatgagaa   2520

aaattgattt gtgattgtgt atatgagtca ttgttaatgg gagacaagct gaactgccac   2580

atgccaccaa atgaaccttt acttcaatca aaaaggaggg tatgattggt tcaattatat   2640

taacagaata tcatgggcat ttctctatga tggtcattca aggtagtagg tctctttcaa   2700

ctgagtgcaa cattgagaat aatgatttgg ttcagggcaa ctacaaataa tcacttacta   2760

agccttaaat aaagccatta tttttatatc aatagcacaa aggaaaacca aaagtcctta   2820

accactgacc atttttatca tattttaggc ctttttttaa aaaatcaggg tatagtaggc   2880

actaagtttt attaggaaat atttaaacct gctgaaggat ttatttataa aaagtgcaat   2940

ttttcaaaac acattattat tttttaattt cccaattttt tcagtttttc aaattgtacc   3000

acaacataga actgtgatat tttgctatta cttcaatgtg aataaataag gtaaagtata   3060

tcatttattg agtgcccatg ctgtacattt aaaatatgca ttatttaatt taatcttact   3120

cccagcacca aaaggtaatt gaccagcctc aacacaattt tggacaaagc tagtaactga   3180

acacaggtct gtctgcccca cacttctctt tctcttgtaa ctgcacaata gcagaaaatt   3240

ggcaagatgt atttttactt tccaagatgc cgtgtgtgcc aagaataaat gaaatgatgt   3300

taaagcataa taataacata tctttaaaaa gcttttcaaa atatattttc accctgacag   3360

tgacccttgt aacttaaatg atttttggaa atattagtat gtaagtataa ttcaaagttg   3420

tcaaaatgta agacatttag aagtaatttt tattatttat attgttaata cttaatcact   3480

ggaaattcat tttccttact cgatgttttc tttcaactga gaagcctaaa acaaacaaaa   3540

accttgtgtg ttatcctgat atagttgact aaatgtattt gttcttatat ggatagtaat   3600

atgaatgtga catgcaccaa ttgtcctatt ataattttca gataagtgta actaagcact   3660

tgtgtaataa atattagtca ttttatttca a                                  3691


<210>  2747
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  2747

Met Cys Gly Ala Pro Ala Thr Ala Cys Arg Gly His Pro Arg Ala Leu 
1               5                   10                  15


Arg Pro Leu Arg Arg Pro Leu Pro Val Arg Pro Arg Gly Ser Ala Pro 
            20                  25                  30


Arg Arg Gly Arg Gly Ala Gly Ser Arg Gly Gln Leu 
        35                  40


<210>  2748
<211>  4283
<212>  DNA
<213>  Homo sapiens

<400>  2748
gtacaacccg cgaggcccca cactttctgc gccagctggg agtgcgcgcc ctgcagagcc     60

agtgggtggg cggttctagc tcttcccacc ctcactgcgg gcctctgctg tcacacgccc    120

ggggtggcga aacggtcgcc acctgagtct ccattctgct gcagtggccc ctgcgttaaa    180

gctctctcgt ggtgcggctg ccgaggctgc ggtagctcct gcgcccccgt gctggtggcg    240

cagcctctgc ttgctgccga cctggcggaa gggtgcggga gcgcacgcta cgggcagcgt    300

cggtctgcgt ccttcctcct cctattccga cccccgcatc ccacgccccc gcctcgctct    360

acgcctcctc cctggctgca ggcagaccgc ttcacacagc cgcagtgccc tgtgtgtgga    420

cagcctgtgg gagactcgca cgcccacact caccccgcct ggctgcaccc ctgcccagca    480

tgtcggcgct cgagtggtac gcccacaagt ctctaggcga tggtatcttc tggattcaag    540

aacgtttcta cgagtcgggc aaccgtgcca acatctggct ggtgcgcggc tccgagcagg    600

acgtggtgat cgatacaggc ctggggctgc gcagcctccc ggagtacctg tactcctccg    660

gcctcttgca ggaccgagag gccaaagagg acgcggcgcg ccggccactg cttgccgtgg    720

ccacccacgt gcacttcgac cactccggcg gcctctacca gttcgaccgc gtggcagtgc    780

accacgccga ggccgaggcg ctggctcgcg gggacaactt tgagaccgtg acctggcttt    840

ccgatagcga ggtggtgcgg acgcccagcc ccggctggag ggccagacag ttccgggtac    900

aggcggtgca gcccaccctc atcctgcagg atggggatgt gatcaacctt ggtgacagac    960

agctcactgt tatgcacatg ccaggtcact ccaggggcag tatttgctta catgacaaag   1020

accgaaagat tctcttcagt ggagacgtcg tgtatgatgg atcactgatt gactggctcc   1080

catacagcag gataagtgac tatgttggaa cttgtgaacg tctaatagaa ttagtggaca   1140

gaggtctggt agagaaggtg cttcctgggc acttcaatac ctttggtgct gaaaggcttt   1200

ttcgattggc ttctaactat atttcaaaag ctgggatatg tcacaaagtt tctacttttg   1260

ccatgcgatc tcttgcaagt ttagctctac gtgtaacaaa ttctaggacc tcgccctagt   1320

atctatactg ataatatatt ttgattaatt atatacatta attcattctg tgctatttaa   1380

ctgattaata gtgagcattt catgaagtgc ttttatacca ctattatata tcagagaaag   1440

attgagaatg aataagccaa aaagaaaatt gttagtttaa attgttttct ttcttccaag   1500

aaagaagcca cttaaataag cttatacttt gccaaagctg tcatcttgta atatatgctc   1560

tagaaatgac ataaaggttt atggggaagc aaagagagat tttgtggcaa gagaactgcc   1620

cttgcctctg tttttcttgt tttattccct tgatgaccta gggaaaaaaa ggcatgtaga   1680

gtattatgtt tatactttaa acttgatatt tttagtgtat tatttaaaga taaaggttct   1740

tgggtttaaa atacattaga acttaatgca gacatataaa gtaacattga gaatgacaac   1800

taaaacattc cattgttatg gtcctgaatt ttttatgctt catttcatgt atttattctt   1860

tgtataatta tagcatacat gttatgtaat ataacttatg aaaagtacag tgaattttgc   1920

tttattgcaa agctttaaat ataaatttca gagtgcttca gtaaaaagct actatatatt   1980

gttgtttgtt attgtgtagg taatattttc aattatgaaa gtgaaatgca aatgtctgtt   2040

atctaactac aaattgtcag atttcttaaa aggacactgt caggcaaatt tgaaaatata   2100

cacattgaga ataatttttt attattatat cctattttaa tattaacagc tattatgaac   2160

aaaatttttc ctgttaaata gcgacttcag tattgtgtta tgttttacag cgttaaaaca   2220

actatgaaga tctgcagcta ttcttttact taacatgcat atgtactaca gagggatttt   2280

taaattaatt gcaaaatgtg cattagctat tgacttagag tgaattgcct tttgtatcct   2340

gattcacaac acctattcct gttcagtatt ctttgtcttg aatagagaag tctatgttcg   2400

taaagtcata taaaaggtta taccactatt tagtaaaaag ttttagtttg gtgctgttaa   2460

taataatttg ctaaaaggcc ttttagaata tttcataaag ggttttaaac agttttttcc   2520

cactgccttt ttattattga catatctaaa accaaactga aatcgctttg gaaatcagat   2580

tttttaatgt taggaagatc cagcaatttt ggtttctgaa aaattacaaa acttttctac   2640

cctacagatg cccaggttct ttagtttttt attcattcaa ctcacacaca cataaacata   2700

tacatacaca aacacaatcc cacatgcaaa cacacacagc cacatatata catgtgtagc   2760

acagcgctaa acactgtgga ggctaaaaaa agtcaaagac aacattataa ctaaaagtcg   2820

aaagcacaca aaatataaat aatagtgtat gcaagttaat gtacattata catgcgtgta   2880

agggacataa atggaggggt gtgaactttg gttaggcaaa gtttactgga ggaggggttt   2940

ttgagtcaaa tttggaagga tgaacttgtt agatagtcag agttggaaac aaaacaatcc   3000

aagaataggg atataagcat tgctagtcta gaatagtcta ttccttgtga aaatataaat   3060

ttaattttca ggaatccagt atattccaaa catcacatat ttagcatgag aaaaattgat   3120

ttgtgattgt gtatatgagt cattgttaat gggagacaag ctgaactgcc acatgccacc   3180

aaatgaacct ttacttcaat caaaaaggag ggtatgattg gttcaattat attaacagaa   3240

tatcatgggc atttctctat gatggtcatt caaggtagta ggtctctttc aactgagtgc   3300

aacattgaga ataatgattt ggttcagggc aactacaaat aatcacttac taagccttaa   3360

ataaagccat tatttttata tcaatagcac aaaggaaaac caaaagtcct taaccactga   3420

ccatttttat catattttag gccttttttt aaaaaatcag ggtatagtag gcactaagtt   3480

ttattaggaa atatttaaac ctgctgaagg atttatttat aaaaagtgca atttttcaaa   3540

acacattatt attttttaat ttcccaattt tttcagtttt tcaaattgta ccacaacata   3600

gaactgtgat attttgctat tacttcaatg tgaataaata aggtaaagta tatcatttat   3660

tgagtgccca tgctgtacat ttaaaatatg cattatttaa tttaatctta ctcccagcac   3720

caaaaggtaa ttgaccagcc tcaacacaat tttggacaaa gctagtaact gaacacaggt   3780

ctgtctgccc cacacttctc tttctcttgt aactgcacaa tagcagaaaa ttggcaagat   3840

gtatttttac tttccaagat gccgtgtgtg ccaagaataa atgaaatgat gttaaagcat   3900

aataataaca tatctttaaa aagcttttca aaatatattt tcaccctgac agtgaccctt   3960

gtaacttaaa tgatttttgg aaatattagt atgtaagtat aattcaaagt tgtcaaaatg   4020

taagacattt agaagtaatt tttattattt atattgttaa tacttaatca ctggaaattc   4080

attttcctta ctcgatgttt tctttcaact gagaagccta aaacaaacaa aaaccttgtg   4140

tgttatcctg atatagttga ctaaatgtat ttgttcttat atggatagta atatgaatgt   4200

gacatgcacc aattgtccta ttataatttt cagataagtg taactaagca cttgtgtaat   4260

aaatattagt cattttattt caa                                           4283


<210>  2749
<211>  279
<212>  PRT
<213>  Homo sapiens

<400>  2749

Met Ser Ala Leu Glu Trp Tyr Ala His Lys Ser Leu Gly Asp Gly Ile 
1               5                   10                  15


Phe Trp Ile Gln Glu Arg Phe Tyr Glu Ser Gly Asn Arg Ala Asn Ile 
            20                  25                  30


Trp Leu Val Arg Gly Ser Glu Gln Asp Val Val Ile Asp Thr Gly Leu 
        35                  40                  45


Gly Leu Arg Ser Leu Pro Glu Tyr Leu Tyr Ser Ser Gly Leu Leu Gln 
    50                  55                  60


Asp Arg Glu Ala Lys Glu Asp Ala Ala Arg Arg Pro Leu Leu Ala Val 
65                  70                  75                  80


Ala Thr His Val His Phe Asp His Ser Gly Gly Leu Tyr Gln Phe Asp 
                85                  90                  95


Arg Val Ala Val His His Ala Glu Ala Glu Ala Leu Ala Arg Gly Asp 
            100                 105                 110


Asn Phe Glu Thr Val Thr Trp Leu Ser Asp Ser Glu Val Val Arg Thr 
        115                 120                 125


Pro Ser Pro Gly Trp Arg Ala Arg Gln Phe Arg Val Gln Ala Val Gln 
    130                 135                 140


Pro Thr Leu Ile Leu Gln Asp Gly Asp Val Ile Asn Leu Gly Asp Arg 
145                 150                 155                 160


Gln Leu Thr Val Met His Met Pro Gly His Ser Arg Gly Ser Ile Cys 
                165                 170                 175


Leu His Asp Lys Asp Arg Lys Ile Leu Phe Ser Gly Asp Val Val Tyr 
            180                 185                 190


Asp Gly Ser Leu Ile Asp Trp Leu Pro Tyr Ser Arg Ile Ser Asp Tyr 
        195                 200                 205


Val Gly Thr Cys Glu Arg Leu Ile Glu Leu Val Asp Arg Gly Leu Val 
    210                 215                 220


Glu Lys Val Leu Pro Gly His Phe Asn Thr Phe Gly Ala Glu Arg Leu 
225                 230                 235                 240


Phe Arg Leu Ala Ser Asn Tyr Ile Ser Lys Ala Gly Ile Cys His Lys 
                245                 250                 255


Val Ser Thr Phe Ala Met Arg Ser Leu Ala Ser Leu Ala Leu Arg Val 
            260                 265                 270


Thr Asn Ser Arg Thr Ser Pro 
        275


<210>  2750
<211>  2510
<212>  DNA
<213>  Homo sapiens

<400>  2750
gtacaacccg cgaggcccca cactttctgc gccagctggg agtgcgcgcc ctgcagagcc     60

agtgggtggg cggttctagc tcttcccacc ctcactgcgg gcctctgctg tcacacgccc    120

ggggtggcga aacggtcgcc acctgagtct ccattctgct gcagtggccc ctgcgttaaa    180

gctctctcgt ggtgcggctg ccgaggctgc ggtagctcct gcgcccccgt gctggtggcg    240

cagcctctgc ttgctgccga cctggcggaa gggtgcggga gcgcacgcta cgggcagcgt    300

cggtctgcgt ccttcctcct cctattccga cccccgcatc ccacgccccc gcctcgctct    360

acgcctcctc cctggctgca ggcagaccgc ttcacacagc cgcagtgccc tgtgtgtgga    420

cagcctgtgg gagactcgca cgcccacact caccccgcct ggctgcaccc ctgcccagca    480

tgtcggcgct cgagtggtac gcccacaagt ctctaggcga tggtatcttc tggattcaag    540

aacgtttcta cgagtcgggc aaccgtgcca acatctggct ggtgcgcggc tccgagcagg    600

acgtggtgat cgatacaggc ctggggctgc gcagcctccc ggagtacctg tactcctccg    660

gcctcttgca ggaccgagag gccaaagagg acgcggcgcg ccggccactg cttgccgtgg    720

ccacccacgt gcacttcgac cactccggcg gcctctacca gttcgaccgc gtggcagtgc    780

accacgccga ggccgaggcg ctggctcgcg gggacaactt tgagaccgtg acctggcttt    840

ccgatagcga ggtggtgcgg acgcccagcc ccggctggag ggccagacag ttccgggtac    900

aggcggtgca gcccaccctc atcctgcagg atggggatgt gatcaacctt ggtgacagac    960

agctcactgt tatgcacatg ccaggtcact ccaggggcag tatttgctta catgacaaag   1020

accgaaagat tctcttcagt ggagacgtcg tgtatgatgg atcactgatt gactggctcc   1080

catacagcag gataagtgac tatgttggaa cttgtgaacg tctaatagaa ttagtggaca   1140

gaggtctggt agagaaggtg cttcctgggc acttcaatac ctttggtgct gaaaggcttt   1200

ttcgattggc ttctaactat atttcaaaag ctgggatatg tcacaaagtt tctacttttg   1260

ccatgcgatc tcttgcaagt ttagctctac gtgtaacaaa ttctaggacc tcgccctagt   1320

atctatactg ataatatatt ttgattaatt atatacatta attcattctg tgctatttaa   1380

ctgattaata gtgagcattt catgaagtgc ttttatacca ctattatata tcagagaaag   1440

attgagaatg aataagccaa aaagaaaatt gttagtttaa attgttttct ttcttccaag   1500

aaagaagcca cttaaataag cttatacttt gccaaagctg tcatcttgta atatatgctc   1560

tagaaatgac ataaaggttt atggggaagc aaagagagat tttgtggcaa gagaactgcc   1620

cttgcctctg tttttcttgt tttattccct tgatgaccta gggaaaaaaa ggcatgtaga   1680

gtattatgtt tatactttaa acttgatatt tttagtgtat tatttaaaga taaaggttct   1740

tgggtttaaa atacattaga acttaatgca gacatataaa gtaacattga gaatgacaac   1800

taaaacattc cattgttatg gtcctgaatt ttttatgctt catttcatgt atttattctt   1860

tgtataatta tagcatacat gttatgtaat ataacttatg aaaagtacag tgaattttgc   1920

tttattgcaa agctttaaat ataaatttca gagtgcttca gtaaaaagct actatatatt   1980

gttgtttgtt attgtgtagg taatattttc aattatgaaa gtgaaatgca aatgtctgtt   2040

atctaactac aaattgtcag atttcttaaa aggacactgt caggcaaatt tgaaaatata   2100

cacattgaga ataatttttt attattatat cctattttaa tattaacagc tattatgaac   2160

aaaatttttc ctgttaaata gcgacttcag tattgtgtta tgttttacag cgttaaaaca   2220

actatgaaga tctgcagcta ttcttttact taacatgcat atgtactaca gagggatttt   2280

taaattaatt gcaaaatgtg cattagctat tgacttagag tgaattgcct tttgtatcct   2340

gattcacaac acctattcct gttcagtatt ctttgtcttg aatagagaag tctatgttcg   2400

taaagtcata taaaaggtta taccactatt tagtaaaaag ttttagtttg gtgctgttaa   2460

taataatttg ctaaaaggcc ttttagaata tttcataaag ggttttaaac              2510


<210>  2751
<211>  279
<212>  PRT
<213>  Homo sapiens

<400>  2751

Met Ser Ala Leu Glu Trp Tyr Ala His Lys Ser Leu Gly Asp Gly Ile 
1               5                   10                  15


Phe Trp Ile Gln Glu Arg Phe Tyr Glu Ser Gly Asn Arg Ala Asn Ile 
            20                  25                  30


Trp Leu Val Arg Gly Ser Glu Gln Asp Val Val Ile Asp Thr Gly Leu 
        35                  40                  45


Gly Leu Arg Ser Leu Pro Glu Tyr Leu Tyr Ser Ser Gly Leu Leu Gln 
    50                  55                  60


Asp Arg Glu Ala Lys Glu Asp Ala Ala Arg Arg Pro Leu Leu Ala Val 
65                  70                  75                  80


Ala Thr His Val His Phe Asp His Ser Gly Gly Leu Tyr Gln Phe Asp 
                85                  90                  95


Arg Val Ala Val His His Ala Glu Ala Glu Ala Leu Ala Arg Gly Asp 
            100                 105                 110


Asn Phe Glu Thr Val Thr Trp Leu Ser Asp Ser Glu Val Val Arg Thr 
        115                 120                 125


Pro Ser Pro Gly Trp Arg Ala Arg Gln Phe Arg Val Gln Ala Val Gln 
    130                 135                 140


Pro Thr Leu Ile Leu Gln Asp Gly Asp Val Ile Asn Leu Gly Asp Arg 
145                 150                 155                 160


Gln Leu Thr Val Met His Met Pro Gly His Ser Arg Gly Ser Ile Cys 
                165                 170                 175


Leu His Asp Lys Asp Arg Lys Ile Leu Phe Ser Gly Asp Val Val Tyr 
            180                 185                 190


Asp Gly Ser Leu Ile Asp Trp Leu Pro Tyr Ser Arg Ile Ser Asp Tyr 
        195                 200                 205


Val Gly Thr Cys Glu Arg Leu Ile Glu Leu Val Asp Arg Gly Leu Val 
    210                 215                 220


Glu Lys Val Leu Pro Gly His Phe Asn Thr Phe Gly Ala Glu Arg Leu 
225                 230                 235                 240


Phe Arg Leu Ala Ser Asn Tyr Ile Ser Lys Ala Gly Ile Cys His Lys 
                245                 250                 255


Val Ser Thr Phe Ala Met Arg Ser Leu Ala Ser Leu Ala Leu Arg Val 
            260                 265                 270


Thr Asn Ser Arg Thr Ser Pro 
        275


<210>  2752
<211>  3607
<212>  DNA
<213>  Homo sapiens

<400>  2752
ccatcctgca ggatgagggt gggctgcacc gcctgtaccc ggaactgtct ggccctccag     60

ccggggctgg gcgtccgcac cacctcgcta tcggaaagcc aggtcacggt ctcaaagttg    120

tccccgcgag ccagcgcctc ggcctcggcg tggtgcactg ccacgcggtc gaactggtag    180

aggccgccgg agtggtcgaa gtgcacgtgg gtggccacgg caagcagtgg ccggcgcgcc    240

gcgtcctctt tggcctctcg gtcctgcaag aggccggagg agtacaggta ctccgggagg    300

ctgcgcagcc ccaggcctgt atcgatcacc acgtcctgct cggagccgcg caccagccag    360

atgttggcac ggttgcccga ctcgtagaaa cgttcttgaa tccagaagat accatcgcct    420

agagacttgt gggcgtacca ctcgagcgcc gacatgctgg gcaggggtgc agccaggcgg    480

gtgcctttca gaatttgccc actcatctgg tataactggt tctgatggct gggaataaag    540

gaagaggacg tgctgcttat acctttaata ttgaggctgt tggatttagc aaaggtgaaa    600

agttacctga tgtagtgttg aaaccacccc cactatttcc tgatacagat tataaaccag    660

tgccactgaa aacaggagaa ggtgaagaat atatgctggc tttgaaacag gagttgagag    720

aaacaatgaa aagaatgcct tattttattg aaacacctga agaaagacaa gatattgaaa    780

ggtatagtaa aagatacatg aaggtataca aggaagaatg gataccagat tggagaagac    840

ttccaagaga gatgatgcca agaaataaat gtaaaaaagc aggcccaaaa cccaaaaagg    900

caaaagacgc aggcaaaggc acaccactca ctaatactga agatgtgttg aaaaaaatgg    960

aggaattgga aaaaagaggt gatggtgaaa aatcagatga ggaaaatgaa gagaaagaag   1020

gaagcaaaga gaaaagtaaa gaaggtgatg atgacgatga cgatgatgcc gcagaacagg   1080

aggaatatga tgaagaagag caagaagagg aaaatgacta cattaattca tactttgaag   1140

atggagatga ttttggcgca gacagtgatg acaacatgga tgaggcaacc tattaggcat   1200

gaaatttttc aaaaaatatt tttatgatgc agcttctgaa catttggaca gacttgattt   1260

gtattttatt tctgataagg aataagtact tgtttctgtt gttttggaca aatagttgtt   1320

accaaaatat tcaaaaccac tttgagttta catactagtt accttaaaaa ttattccctg   1380

acactctgac attccttcta aacacctctg ccatctctct tatgtactct catgggtttt   1440

tttgtatgat ttgaatatga atgtgcctaa agaatttttg ctctcttaat ctatgtatac   1500

atacttgaac aaatcattct tgcttaactg ctgatctttt gtaaaactat tgctagtcat   1560

aatggatttc tataacctga aagttgatat aatacagcac gtggagcact ttaaaaacaa   1620

agaaacttga aaataatttt attttttacc tttacatggt gtgttctaga ctactgcatt   1680

atgactacat aaacctacct gagctcttac aagtacagaa ttgtgagaca gaggttttgt   1740

gatggaaaac atacacatag ggaaaaatac caaactgagc aatataaatt tcacagctca   1800

catcttagcc agtacaaaga aactttcaca tggggtgaat attataatac ttgaatttga   1860

gacttaatac tgtatatgaa ttaatcatcc cactgtaata actgacatct tcaaatagtt   1920

gggcttatga aaaatttgac taagacattt tattttatac tttatgtaaa tgtgaaataa   1980

gttctggtca tataaatatg tagaatgcat gtgtgtgaac tctatgaagt gaagtgtggt   2040

ggccttttat gtttcagagt actcaagtgt acaattgatt tatataaaaa tgcaaaatga   2100

actcaggtca ttttgaaatt aatattaata tttttgttgt ttaactttaa agctagctcc   2160

cctaacttta tatatttttt gggaaaaaat acctaaaaac ctcagcctac aaagactctc   2220

agaaatgcca aagattttca aggaaattca tattatatat ttcaaaaatg atttatcaat   2280

gttatctacc aaaagaaata attttatttt tcccctttgg ggagatatta tcctctaata   2340

tgagaatcag atccctagat tctatttcta cctatactat taaactcaac cttgaacctg   2400

agcttggttg tttctgtgcc ttagtttctc cactcgtaaa caatttccta taaaaattgt   2460

ttaaacacca accaaaattt accatatgta ttcattctct tgccttaaag atcacttctt   2520

aacttacatt tggctctcac cctctaaaaa tttgtagttt ggagagtaac tgaaagcaca   2580

attttaagaa acatgttttc ctcacaaaat atattgtaat ctgattttcc tatcttgtat   2640

tcatgcagaa aattggagaa aatgtgtatt gtcttgtgcc attctgcaat atgaatttct   2700

caggaaaaag atgtttcaat ggcaatactt tcttaaataa ttcaagatgg gtgtgaggac   2760

ctatcttatt agtttagtgc tgtgttaacc atttgtgaat tacttcttgt ttaaaggaag   2820

ttgtcaaaaa attttaagat tctaaatgga atacacgaat aaagtaagcc ttagaataga   2880

aacctcacaa aaagttgtca tttgcggttg ataattaaca taggtgtttt attctctcaa   2940

ctccttagta ccagagccaa atacaattta gttttcagaa atcttatcaa tattgttcta   3000

tttacctact tataaatctg cagataacca cttgaaccag gcaaatacac tgaagataaa   3060

ggttatttct ttttttagct ttgaatttgt catgaccatt ttagtcttgc agatagcagg   3120

gcagcccctt ggggcaagga tttactctgg gaggtaccgt taagagcctt ctttccccct   3180

ttgaaagatc cttttacaat gttaaagtat actagttgca agaacaagca ggatttgcag   3240

gttgctttac cagcatgagt ctcatttttc tggcttaaaa tctgggactg tgaaattatt   3300

ccataggaaa gtgaatgtta ttttgcagaa ttagcctctt acataaaagt atttgttgaa   3360

gtgtctttaa aattgctatc atgagcaaaa ctggttgctg taatgcttgt ttttctgtat   3420

ttatttacac attaaattct tacaaaacaa aatgtgttcg tttgttttat agtaagatgt   3480

tttattttga acttatttaa atgtttattt gttagagaaa actaatttgt taatatagat   3540

cttaactagt aactattaag cagggatgtt tgttccaaat attcttgaat aaacaatcac   3600

cacaaac                                                             3607


<210>  2753
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  2753

Met Ala Gly Asn Lys Gly Arg Gly Arg Ala Ala Tyr Thr Phe Asn Ile 
1               5                   10                  15


Glu Ala Val Gly Phe Ser Lys Gly Glu Lys Leu Pro Asp Val Val Leu 
            20                  25                  30


Lys Pro Pro Pro Leu Phe Pro Asp Thr Asp Tyr Lys Pro Val Pro Leu 
        35                  40                  45


Lys Thr Gly Glu Gly Glu Glu Tyr Met Leu Ala Leu Lys Gln Glu Leu 
    50                  55                  60


Arg Glu Thr Met Lys Arg Met Pro Tyr Phe Ile Glu Thr Pro Glu Glu 
65                  70                  75                  80


Arg Gln Asp Ile Glu Arg Tyr Ser Lys Arg Tyr Met Lys Val Tyr Lys 
                85                  90                  95


Glu Glu Trp Ile Pro Asp Trp Arg Arg Leu Pro Arg Glu Met Met Pro 
            100                 105                 110


Arg Asn Lys Cys Lys Lys Ala Gly Pro Lys Pro Lys Lys Ala Lys Asp 
        115                 120                 125


Ala Gly Lys Gly Thr Pro Leu Thr Asn Thr Glu Asp Val Leu Lys Lys 
    130                 135                 140


Met Glu Glu Leu Glu Lys Arg Gly Asp Gly Glu Lys Ser Asp Glu Glu 
145                 150                 155                 160


Asn Glu Glu Lys Glu Gly Ser Lys Glu Lys Ser Lys Glu Gly Asp Asp 
                165                 170                 175


Asp Asp Asp Asp Asp Ala Ala Glu Gln Glu Glu Tyr Asp Glu Glu Glu 
            180                 185                 190


Gln Glu Glu Glu Asn Asp Tyr Ile Asn Ser Tyr Phe Glu Asp Gly Asp 
        195                 200                 205


Asp Phe Gly Ala Asp Ser Asp Asp Asn Met Asp Glu Ala Thr Tyr 
    210                 215                 220


<210>  2754
<211>  3136
<212>  DNA
<213>  Homo sapiens

<400>  2754
actccgcggt cctggtgccg cgtgcaggtc ggtgcgcgct tctcccgagg tggaacgggc     60

ggcagtcaag cgccggcgtt ctctgccgtc accctttcct tgccggccgg cacttcggct    120

gcagagtttt gcccacgctt cgagacttag ggagcagtgc ctttcagaat ttgcccactc    180

atctggtata actggttctg atggctggga ataaaggaag aggacgtgct gcttatacct    240

ttaatattga ggctgttgga tttagcaaag gtgaaaagtt acctgatgta gtgttgaaac    300

cacccccact atttcctgat acagattata aaccagtgcc actgaaaaca ggagaaggtg    360

aagaatatat gctggctttg aaacaggagt tgagagaaac aatgaaaaga atgccttatt    420

ttattgaaac acctgaagaa agacaagata ttgaaaggta tagtaaaaga tacatgaagg    480

tatacaagga agaatggata ccagattgga gaagacttcc aagagagatg atgccaagaa    540

ataaatgtaa aaaagcaggc ccaaaaccca aaaaggcaaa agacgcaggc aaaggcacac    600

cactcactaa tactgaagat gtgttgaaaa aaatggagga aaatgactac attaattcat    660

actttgaaga tggagatgat tttggcgcag acagtgatga caacatggat gaggcaacct    720

attaggcatg aaatttttca aaaaatattt ttatgatgca gcttctgaac atttggacag    780

acttgatttg tattttattt ctgataagga ataagtactt gtttctgttg ttttggacaa    840

atagttgtta ccaaaatatt caaaaccact ttgagtttac atactagtta ccttaaaaat    900

tattccctga cactctgaca ttccttctaa acacctctgc catctctctt atgtactctc    960

atgggttttt ttgtatgatt tgaatatgaa tgtgcctaaa gaatttttgc tctcttaatc   1020

tatgtataca tacttgaaca aatcattctt gcttaactgc tgatcttttg taaaactatt   1080

gctagtcata atggatttct ataacctgaa agttgatata atacagcacg tggagcactt   1140

taaaaacaaa gaaacttgaa aataatttta ttttttacct ttacatggtg tgttctagac   1200

tactgcatta tgactacata aacctacctg agctcttaca agtacagaat tgtgagacag   1260

aggttttgtg atggaaaaca tacacatagg gaaaaatacc aaactgagca atataaattt   1320

cacagctcac atcttagcca gtacaaagaa actttcacat ggggtgaata ttataatact   1380

tgaatttgag acttaatact gtatatgaat taatcatccc actgtaataa ctgacatctt   1440

caaatagttg ggcttatgaa aaatttgact aagacatttt attttatact ttatgtaaat   1500

gtgaaataag ttctggtcat ataaatatgt agaatgcatg tgtgtgaact ctatgaagtg   1560

aagtgtggtg gccttttatg tttcagagta ctcaagtgta caattgattt atataaaaat   1620

gcaaaatgaa ctcaggtcat tttgaaatta atattaatat ttttgttgtt taactttaaa   1680

gctagctccc ctaactttat atattttttg ggaaaaaata cctaaaaacc tcagcctaca   1740

aagactctca gaaatgccaa agattttcaa ggaaattcat attatatatt tcaaaaatga   1800

tttatcaatg ttatctacca aaagaaataa ttttattttt cccctttggg gagatattat   1860

cctctaatat gagaatcaga tccctagatt ctatttctac ctatactatt aaactcaacc   1920

ttgaacctga gcttggttgt ttctgtgcct tagtttctcc actcgtaaac aatttcctat   1980

aaaaattgtt taaacaccaa ccaaaattta ccatatgtat tcattctctt gccttaaaga   2040

tcacttctta acttacattt ggctctcacc ctctaaaaat ttgtagtttg gagagtaact   2100

gaaagcacaa ttttaagaaa catgttttcc tcacaaaata tattgtaatc tgattttcct   2160

atcttgtatt catgcagaaa attggagaaa atgtgtattg tcttgtgcca ttctgcaata   2220

tgaatttctc aggaaaaaga tgtttcaatg gcaatacttt cttaaataat tcaagatggg   2280

tgtgaggacc tatcttatta gtttagtgct gtgttaacca tttgtgaatt acttcttgtt   2340

taaaggaagt tgtcaaaaaa ttttaagatt ctaaatggaa tacacgaata aagtaagcct   2400

tagaatagaa acctcacaaa aagttgtcat ttgcggttga taattaacat aggtgtttta   2460

ttctctcaac tccttagtac cagagccaaa tacaatttag ttttcagaaa tcttatcaat   2520

attgttctat ttacctactt ataaatctgc agataaccac ttgaaccagg caaatacact   2580

gaagataaag gttatttctt tttttagctt tgaatttgtc atgaccattt tagtcttgca   2640

gatagcaggg cagccccttg gggcaaggat ttactctggg aggtaccgtt aagagccttc   2700

tttccccctt tgaaagatcc ttttacaatg ttaaagtata ctagttgcaa gaacaagcag   2760

gatttgcagg ttgctttacc agcatgagtc tcatttttct ggcttaaaat ctgggactgt   2820

gaaattattc cataggaaag tgaatgttat tttgcagaat tagcctctta cataaaagta   2880

tttgttgaag tgtctttaaa attgctatca tgagcaaaac tggttgctgt aatgcttgtt   2940

tttctgtatt tatttacaca ttaaattctt acaaaacaaa atgtgttcgt ttgttttata   3000

gtaagatgtt ttattttgaa cttatttaaa tgtttatttg ttagagaaaa ctaatttgtt   3060

aatatagatc ttaactagta actattaagc agggatgttt gttccaaata ttcttgaata   3120

aacaatcacc acaaac                                                   3136


<210>  2755
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  2755

Met Ala Gly Asn Lys Gly Arg Gly Arg Ala Ala Tyr Thr Phe Asn Ile 
1               5                   10                  15


Glu Ala Val Gly Phe Ser Lys Gly Glu Lys Leu Pro Asp Val Val Leu 
            20                  25                  30


Lys Pro Pro Pro Leu Phe Pro Asp Thr Asp Tyr Lys Pro Val Pro Leu 
        35                  40                  45


Lys Thr Gly Glu Gly Glu Glu Tyr Met Leu Ala Leu Lys Gln Glu Leu 
    50                  55                  60


Arg Glu Thr Met Lys Arg Met Pro Tyr Phe Ile Glu Thr Pro Glu Glu 
65                  70                  75                  80


Arg Gln Asp Ile Glu Arg Tyr Ser Lys Arg Tyr Met Lys Val Tyr Lys 
                85                  90                  95


Glu Glu Trp Ile Pro Asp Trp Arg Arg Leu Pro Arg Glu Met Met Pro 
            100                 105                 110


Arg Asn Lys Cys Lys Lys Ala Gly Pro Lys Pro Lys Lys Ala Lys Asp 
        115                 120                 125


Ala Gly Lys Gly Thr Pro Leu Thr Asn Thr Glu Asp Val Leu Lys Lys 
    130                 135                 140


Met Glu Glu Asn Asp Tyr Ile Asn Ser Tyr Phe Glu Asp Gly Asp Asp 
145                 150                 155                 160


Phe Gly Ala Asp Ser Asp Asp Asn Met Asp Glu Ala Thr Tyr 
                165                 170


<210>  2756
<211>  679
<212>  DNA
<213>  Homo sapiens

<400>  2756
cgcgcttctc ccgaggtgga acgggcggca gtcaagcgcc ggcgttctct gccgtcaccc     60

tttccttgcc ggccggcact tcggctgcag agttttgccc acgcttcgag acttagggag    120

cagtgccttt cagaatttgc ccactcatct ggtataactg gttctgatgg ctgggaataa    180

aggaagagga cgtgctgctt atacctttaa tattgaggct gttggattta gcaaaggtga    240

aaagttacct gatgtagtgt tgaaaccacc cccactattt cctgatacag attataaacc    300

agtgccactg aaaacaggag aaggtgaaga atatatgctg gctttgaaac aggagttgag    360

agaaacaatg aaaagaatgc cttattttat tgaaacacct gaagaaagac aagagacggg    420

agtcttgctt ttttgctcac actggtctca cattcctggc ttcaagtgat cctcccatct    480

cggccttcca aagtgctgaa attacaggca tgagccaccg cacccagctt acctctgttt    540

cctgatatag tgtttaaaaa acacacgcat gttaaaaata aaggtttttc tataaaatat    600

atacatttat atgtgcctat ataggtttat ataatatgtg tatatatgtg catacataaa    660

tttatataat atccatgct                                                 679


<210>  2757
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  2757

Met Ala Gly Asn Lys Gly Arg Gly Arg Ala Ala Tyr Thr Phe Asn Ile 
1               5                   10                  15


Glu Ala Val Gly Phe Ser Lys Gly Glu Lys Leu Pro Asp Val Val Leu 
            20                  25                  30


Lys Pro Pro Pro Leu Phe Pro Asp Thr Asp Tyr Lys Pro Val Pro Leu 
        35                  40                  45


Lys Thr Gly Glu Gly Glu Glu Tyr Met Leu Ala Leu Lys Gln Glu Leu 
    50                  55                  60


Arg Glu Thr Met Lys Arg Met Pro Tyr Phe Ile Glu Thr Pro Glu Glu 
65                  70                  75                  80


Arg Gln Glu Thr Gly Val Leu Leu Phe Cys Ser His Trp Ser His Ile 
                85                  90                  95


Pro Gly Phe Lys 
            100


<210>  2758
<211>  6735
<212>  DNA
<213>  Homo sapiens

<400>  2758
gtgaatcaaa ggagagtccc agaaaacctg tgactgttga agaaaattca tctgtgaatt     60

tttatattca aggagtcagt atttatattc atcttttaaa ctgggaagat ttatatttta    120

ctttaaaact tcttgataat aatttacaat gaatggacac agtgatgaag aaagtgttag    180

aaacagtagt ggagaatcaa gccagtcgga tgatgattct gggtcagctt caggctctgg    240

atctggttcg agttctggaa gcagtagtga tggaagcagt agccagtcag gtagcagtga    300

ctctgactcc ggatctgaat caggcagtca gtcagagtct gagtcagaca cttcccgaga    360

aaacaaagtt caagcaaaac caccgaaagt tgatggagct gagttttgga aatctagtcc    420

tagtattctg gccgttcaga gatctgcaat cctcaagaag cagcaacagc agcagcagca    480

acaacaacat caagcctcat ctaatagcgg atcagaagag gattcctcta gcagtgaaga    540

ttccgatgac tcatcaagtg aggtcaaaag gaaaaagcat aaagatgaag attggcaaat    600

gtctgggtca ggatctccat ctcagtctgg ttcagattca gaatctgaag aagagagaga    660

gaaaagcagt tgtgatgaaa cagaatctga ttatgagcca aaaaacaaag tcaaaagcag    720

aaaacctcaa aatagatcta agtcaaaaaa tggaaagaag attcttggac aaaaaaagag    780

acagattgat tcatctgagg aggatgatga tgaagaagat tatgataatg ataaaagaag    840

ttctcgtcgc caagcaactg ttaatgttag ctataaggag gatgaagaaa tgaaaacaga    900

ttctgatgac ctactggaag tctgtggaga ggatgttcct caacctgagg aagaggaatt    960

tgaaaccata gaaagattta tggattgtcg gattgggaga aaaggagcta ctggtgctac   1020

tacaaccatc tatgcagttg aagcagatgg tgacccaaat gcaggctttg aaaaaaacaa   1080

agaaccagga gagattcagt atttaattaa atggaaagga tggtcccata tccacaacac   1140

ttgggagaca gaagaaaccc tcaagcagca gaatgttaga ggaatgaaaa aattggataa   1200

ttataagaaa aaagatcagg aaacaaaaag atggttgaaa aatgcctctc cagaagatgt   1260

ggaatattat aattgccagc aagaacttac agatgatcta cataaacagt atcaaatagt   1320

ggaacgtata attgctcatt ccaatcaaaa gtcagcagct ggttatcctg attattactg   1380

caaatggcag ggccttccat actcagagtg cagctgggaa gatggagctc tcatttccaa   1440

aaagtttcaa gcatgcattg atgagtattt tagcaggaac caatcaaaaa ccactccttt   1500

taaagattgc aaagtattaa aacaaaggcc aaggtttgta gccctgaaga agcagccatc   1560

ctatattgga ggacatgagg gcttagaatt aagagattat caactgaatg gtttaaattg   1620

gcttgctcat tcttggtgca aaggaaatag ttgcatactc gctgatgaaa tgggccttgg   1680

aaaaacaata cagacgatct catttctgaa ttatttgttt catgaacatc aattatatgg   1740

acctttttta ttggtagtac cgctctccac tcttacttcc tggcaaaggg aaattcagac   1800

ttgggcttct caaatgaatg ctgtggttta tttaggtgac attaacagca gaaacatgat   1860

aagaactcat gaatggacgc atcatcagac caaacggtta aaatttaata tattgttaac   1920

aacttatgaa attttattaa aagataaggc attccttgga ggtctaaatt gggcatttat   1980

aggtgttgat gaagcacacc gattaaagaa tgatgactcc cttctgtata aaactttaat   2040

agattttaaa tccaatcatc gtctccttat cactggaact cctctacaga attccctcaa   2100

agagctctgg tctttgctac atttcattat gccagaaaag ttttcttcct gggaagattt   2160

tgaagaagaa catggcaaag ggagagaata tggttatgca agccttcaca aggagcttga   2220

gccatttctg ttacgccgag ttaagaaaga tgtggaaaaa tctcttcctg ccaaggttga   2280

gcagatttta agaatggaaa tgagtgcttt acagaaacaa tattacaaat ggattttaac   2340

taggaattac aaagccctca gcaaaggttc caagggcagt acctcaggct ttttgaacat   2400

tatgatggag ctaaagaaat gttgtaacca ttgctacctc attaaaccac cagataataa   2460

tgaattctat aataaacagg aggccttaca acacttaatt cgtagtagcg gaaaattgat   2520

tcttcttgac aagctattaa ttcgcctaag agaacgaggc aatcgagttc ttattttttc   2580

acaaatggtg cggatgttag atatacttgc agaatatttg aaatatcgtc aattcccctt   2640

tcaaagatta gatggatcaa taaaaggaga actgaggaaa caagctctag atcattttaa   2700

tgctgaggga tcagaggatt tttgcttttt gctgtccaca agagctggag gtctagggat   2760

taatttagcc tctgctgaca ctgttgttat atttgattcc gattggaatc cacagaatga   2820

tcttcaggca caggctagag cccatcgaat tgggcaaaag aaacaggtga atatttatcg   2880

tctagttaca aagggatcag ttgaagaaga tattcttgaa agggcgaaaa agaagatggt   2940

tttagatcat cttgtaattc aaagaatgga cacaactggg aagacagtac tacatacagg   3000

ttctgcccca tcaagttcta ctcctttcaa taaagaagag ttatcagcca ttttaaagtt   3060

tggtgctgaa gaacttttta aggaacctga aggagaagaa caagagcccc aggaaatgga   3120

tatagatgaa atcttgaaga gagctgaaac tcatgaaaat gaaccaggtc ctttaactgt   3180

aggagatgaa ttgctttccc agttcaaggt tgccaacttc tcaaatatgg atgaggatga   3240

cattgagttg gaacctgaaa gaaattcaaa gaattgggag gaaattattc cagaagatca   3300

aagaagacga ttagaagaag aagaaagaca aaaggaactt gaagaaattt atatgctccc   3360

aagaatgaga aattgtgcaa aacagattag tttcaatgga agtgaaggga ggcgcagtag   3420

aagtaggaga tactctggat ctgatagtga ttccatctca gaagggaaaa ggccaaagaa   3480

acgtggaaga ccacggacta ttcctcggga gaatattaaa ggatttagtg atgcagaaat   3540

taggcggttt atcaagagct ataagaaatt tggtggtcct ctggaaagat tagatgcaat   3600

tgctcgagat gctgagttag ttgataagtc agaaacagac cttagacgac tgggagaatt   3660

ggtacataat ggttgcatta aagcattaaa ggatagttct tcaggaacag aacgaacagg   3720

tggtagactc ggaaaagtga agggtccaac attccgaata tcaggagtac aggtgaatgc   3780

caaactagtc atctcccatg aagaagaatt aatacctttg cacaaatcca ttccttctga   3840

tccagaagaa agaaagcagt atactatccc atgccacaca aaggcagctc attttgatat   3900

agactggggc aaagaagatg attccaattt gttaattggc atctatgaat atggatatgg   3960

aagctgggaa atgattaaaa tggatcctga cctcagtcta acacacaaga ttcttccaga   4020

tgatcccgat aaaaaaccac aagcaaaaca gttgcagacc cgtgcagact acctcatcaa   4080

attacttagt agagatcttg caaaaaaaga agctctttct ggtgcgggaa gttcaaagag   4140

gagaaaagca agagctaaga agaataaagc aatgaagtct ataaaagtga aagaggaaat   4200

aaagagtgat tcttctcctc tgccttcaga gaagtctgat gaagatgatg ataaattgag   4260

tgaatccaag tctgatggta gggaaagatc caagaaatct tcagtgtcag atgctccagt   4320

tcatatcacg gcaagtggtg aaccagttcc catttctgaa gaatctgaag agctggatca   4380

gaagacattc agcatttgta aagaaagaat gaggcctgtt aaagcagctt tgaaacaact   4440

tgataggcct gagaaaggcc tttcagaaag agaacaacta gagcatacta gacaatgttt   4500

aataaaaatt ggagaccata tcacagaatg tctaaaagag tatacaaatc ctgaacaaat   4560

taagcaatgg agaaaaaacc tgtggatttt tgtatctaag tttactgaat ttgatgcaag   4620

aaaattacat aaattatata agcatgctat taaaaaacgg caggagtctc agcaaaacag   4680

tgatcaaaac agcaacttga atcctcacgt gattagaaat ccagatgtgg aaagattaaa   4740

agagaataca aatcacgatg atagcagcag ggacagttat tcctctgata gacacttaac   4800

tcagtaccat gatcatcata aagaccgaca tcagggagat tcttacaaaa aaagtgattc   4860

caggaaaaga ccctattctt cttttagtaa tggtaaagac catcgtgatt gggatcacta   4920

caagcaagac agcagatatt acagtgacag agagaaacac agaaaactgg atgatcacag   4980

gagtagagat cacaggtcaa atttggaagg aagtttaaaa gatagatctc attctgatca   5040

tcgttctcac tcagatcatc ggttacattc agaccaccgg tcaagttctg aatatacgca   5100

ccataaatct tccagggatt ataggtatca ctcagactgg caaatggacc acagagcttc   5160

cagcagtggc cctaggtcac cactagatca gagatctcct tatggctcca gatctccatt   5220

tgaacattca gttgaacaca aaagtacacc ggagcatacc tggagtagtc ggaaaacata   5280

acaaaaactg atacttcgtc tttctggact tttcttttag ccatatatca taaaccaaca   5340

cagtaattgc cttacatgac ttgaaagata taaacagatc ttctatcagt agcagtattg   5400

ttacttcttt ccaggatgca aggtctatta tcccaacaga agagaaaata tttttatatt   5460

taaggattat gctgcactgt actacaaaat tgtagtactt ttttttgttt tcttttttaa   5520

agaaatggaa aatgtttact attacaggga cctcaacact gccctcccat acaggctgga   5580

taaaactgtt tttaagtcag tgattttaga ctgacctcca tttaaattat gtttatatat   5640

gaactttact ctgacctgtg atcatgtttc aggaaggaat gaaagagagt tctttcttaa   5700

taaagaaaaa cactcaagga ctttgttcat ttccaaagct acttgtttac attgtacact   5760

gcgaccacct tgccgctttt catcacaagc ttgaatattt aaattctgta cttatatctg   5820

taaaatagcc aggaatttcc tgtttgtgat ctattatgcc tttttacaaa aaaaatggct   5880

gtaaattatt gtaaatatta aaggaacttt ccttacttcc ttccctttct caggcttttt   5940

ttgactgttc ctttccctac caactcaggc cttcttatta aaaaaaaaaa aatcagtgta   6000

ataacacttt ttaatgattt gtcttgatgg aatcattgtt tagaatgtaa aaatggggaa   6060

aggggccact taattccatt agtcctcttt ttatactgaa tattttatta gatacatgtt   6120

attccctttt ttttcctttt ttagtcaata ttgtgtttgt agttttaaaa aatggcgaga   6180

tatgtaaaat ctaaactgca tgctctggaa acactttttt cagatgcatc tggtttaaaa   6240

gggtaggtgt ataaacactt ttcagaatcc aaaacggcca aaagttattg taaatccgtt   6300

tgttttcccg ttttatgtgg gcaataatgt caaatgtgct atgcagccag gttaacattt   6360

tagataaact tgattgactt ttaatataaa ctgttacaat gcacactgat tgtatataaa   6420

aacgttatat atgacaaatt aaatttaaga aaaaggatat gtgggctcct gtaattttct   6480

gctgcattct tactccctca agcacttacc accaccacca ccgcccccta cccccgtttt   6540

taagtaacat tttgctgcca gaaaaagtat tttggtaagc agttgaatat ttgtaatgtg   6600

tagcattaca actaaatctg ttttggagac tatgaatatt cctatgaagt aaaacttagg   6660

tcatagacat ttttgttggc cccttttggc ttcctacaga tattattatg ggatgcttta   6720

tatttattca cagat                                                    6735


<210>  2759
<211>  1710
<212>  PRT
<213>  Homo sapiens

<400>  2759

Met Asn Gly His Ser Asp Glu Glu Ser Val Arg Asn Ser Ser Gly Glu 
1               5                   10                  15


Ser Ser Gln Ser Asp Asp Asp Ser Gly Ser Ala Ser Gly Ser Gly Ser 
            20                  25                  30


Gly Ser Ser Ser Gly Ser Ser Ser Asp Gly Ser Ser Ser Gln Ser Gly 
        35                  40                  45


Ser Ser Asp Ser Asp Ser Gly Ser Glu Ser Gly Ser Gln Ser Glu Ser 
    50                  55                  60


Glu Ser Asp Thr Ser Arg Glu Asn Lys Val Gln Ala Lys Pro Pro Lys 
65                  70                  75                  80


Val Asp Gly Ala Glu Phe Trp Lys Ser Ser Pro Ser Ile Leu Ala Val 
                85                  90                  95


Gln Arg Ser Ala Ile Leu Lys Lys Gln Gln Gln Gln Gln Gln Gln Gln 
            100                 105                 110


Gln His Gln Ala Ser Ser Asn Ser Gly Ser Glu Glu Asp Ser Ser Ser 
        115                 120                 125


Ser Glu Asp Ser Asp Asp Ser Ser Ser Glu Val Lys Arg Lys Lys His 
    130                 135                 140


Lys Asp Glu Asp Trp Gln Met Ser Gly Ser Gly Ser Pro Ser Gln Ser 
145                 150                 155                 160


Gly Ser Asp Ser Glu Ser Glu Glu Glu Arg Glu Lys Ser Ser Cys Asp 
                165                 170                 175


Glu Thr Glu Ser Asp Tyr Glu Pro Lys Asn Lys Val Lys Ser Arg Lys 
            180                 185                 190


Pro Gln Asn Arg Ser Lys Ser Lys Asn Gly Lys Lys Ile Leu Gly Gln 
        195                 200                 205


Lys Lys Arg Gln Ile Asp Ser Ser Glu Glu Asp Asp Asp Glu Glu Asp 
    210                 215                 220


Tyr Asp Asn Asp Lys Arg Ser Ser Arg Arg Gln Ala Thr Val Asn Val 
225                 230                 235                 240


Ser Tyr Lys Glu Asp Glu Glu Met Lys Thr Asp Ser Asp Asp Leu Leu 
                245                 250                 255


Glu Val Cys Gly Glu Asp Val Pro Gln Pro Glu Glu Glu Glu Phe Glu 
            260                 265                 270


Thr Ile Glu Arg Phe Met Asp Cys Arg Ile Gly Arg Lys Gly Ala Thr 
        275                 280                 285


Gly Ala Thr Thr Thr Ile Tyr Ala Val Glu Ala Asp Gly Asp Pro Asn 
    290                 295                 300


Ala Gly Phe Glu Lys Asn Lys Glu Pro Gly Glu Ile Gln Tyr Leu Ile 
305                 310                 315                 320


Lys Trp Lys Gly Trp Ser His Ile His Asn Thr Trp Glu Thr Glu Glu 
                325                 330                 335


Thr Leu Lys Gln Gln Asn Val Arg Gly Met Lys Lys Leu Asp Asn Tyr 
            340                 345                 350


Lys Lys Lys Asp Gln Glu Thr Lys Arg Trp Leu Lys Asn Ala Ser Pro 
        355                 360                 365


Glu Asp Val Glu Tyr Tyr Asn Cys Gln Gln Glu Leu Thr Asp Asp Leu 
    370                 375                 380


His Lys Gln Tyr Gln Ile Val Glu Arg Ile Ile Ala His Ser Asn Gln 
385                 390                 395                 400


Lys Ser Ala Ala Gly Tyr Pro Asp Tyr Tyr Cys Lys Trp Gln Gly Leu 
                405                 410                 415


Pro Tyr Ser Glu Cys Ser Trp Glu Asp Gly Ala Leu Ile Ser Lys Lys 
            420                 425                 430


Phe Gln Ala Cys Ile Asp Glu Tyr Phe Ser Arg Asn Gln Ser Lys Thr 
        435                 440                 445


Thr Pro Phe Lys Asp Cys Lys Val Leu Lys Gln Arg Pro Arg Phe Val 
    450                 455                 460


Ala Leu Lys Lys Gln Pro Ser Tyr Ile Gly Gly His Glu Gly Leu Glu 
465                 470                 475                 480


Leu Arg Asp Tyr Gln Leu Asn Gly Leu Asn Trp Leu Ala His Ser Trp 
                485                 490                 495


Cys Lys Gly Asn Ser Cys Ile Leu Ala Asp Glu Met Gly Leu Gly Lys 
            500                 505                 510


Thr Ile Gln Thr Ile Ser Phe Leu Asn Tyr Leu Phe His Glu His Gln 
        515                 520                 525


Leu Tyr Gly Pro Phe Leu Leu Val Val Pro Leu Ser Thr Leu Thr Ser 
    530                 535                 540


Trp Gln Arg Glu Ile Gln Thr Trp Ala Ser Gln Met Asn Ala Val Val 
545                 550                 555                 560


Tyr Leu Gly Asp Ile Asn Ser Arg Asn Met Ile Arg Thr His Glu Trp 
                565                 570                 575


Thr His His Gln Thr Lys Arg Leu Lys Phe Asn Ile Leu Leu Thr Thr 
            580                 585                 590


Tyr Glu Ile Leu Leu Lys Asp Lys Ala Phe Leu Gly Gly Leu Asn Trp 
        595                 600                 605


Ala Phe Ile Gly Val Asp Glu Ala His Arg Leu Lys Asn Asp Asp Ser 
    610                 615                 620


Leu Leu Tyr Lys Thr Leu Ile Asp Phe Lys Ser Asn His Arg Leu Leu 
625                 630                 635                 640


Ile Thr Gly Thr Pro Leu Gln Asn Ser Leu Lys Glu Leu Trp Ser Leu 
                645                 650                 655


Leu His Phe Ile Met Pro Glu Lys Phe Ser Ser Trp Glu Asp Phe Glu 
            660                 665                 670


Glu Glu His Gly Lys Gly Arg Glu Tyr Gly Tyr Ala Ser Leu His Lys 
        675                 680                 685


Glu Leu Glu Pro Phe Leu Leu Arg Arg Val Lys Lys Asp Val Glu Lys 
    690                 695                 700


Ser Leu Pro Ala Lys Val Glu Gln Ile Leu Arg Met Glu Met Ser Ala 
705                 710                 715                 720


Leu Gln Lys Gln Tyr Tyr Lys Trp Ile Leu Thr Arg Asn Tyr Lys Ala 
                725                 730                 735


Leu Ser Lys Gly Ser Lys Gly Ser Thr Ser Gly Phe Leu Asn Ile Met 
            740                 745                 750


Met Glu Leu Lys Lys Cys Cys Asn His Cys Tyr Leu Ile Lys Pro Pro 
        755                 760                 765


Asp Asn Asn Glu Phe Tyr Asn Lys Gln Glu Ala Leu Gln His Leu Ile 
    770                 775                 780


Arg Ser Ser Gly Lys Leu Ile Leu Leu Asp Lys Leu Leu Ile Arg Leu 
785                 790                 795                 800


Arg Glu Arg Gly Asn Arg Val Leu Ile Phe Ser Gln Met Val Arg Met 
                805                 810                 815


Leu Asp Ile Leu Ala Glu Tyr Leu Lys Tyr Arg Gln Phe Pro Phe Gln 
            820                 825                 830


Arg Leu Asp Gly Ser Ile Lys Gly Glu Leu Arg Lys Gln Ala Leu Asp 
        835                 840                 845


His Phe Asn Ala Glu Gly Ser Glu Asp Phe Cys Phe Leu Leu Ser Thr 
    850                 855                 860


Arg Ala Gly Gly Leu Gly Ile Asn Leu Ala Ser Ala Asp Thr Val Val 
865                 870                 875                 880


Ile Phe Asp Ser Asp Trp Asn Pro Gln Asn Asp Leu Gln Ala Gln Ala 
                885                 890                 895


Arg Ala His Arg Ile Gly Gln Lys Lys Gln Val Asn Ile Tyr Arg Leu 
            900                 905                 910


Val Thr Lys Gly Ser Val Glu Glu Asp Ile Leu Glu Arg Ala Lys Lys 
        915                 920                 925


Lys Met Val Leu Asp His Leu Val Ile Gln Arg Met Asp Thr Thr Gly 
    930                 935                 940


Lys Thr Val Leu His Thr Gly Ser Ala Pro Ser Ser Ser Thr Pro Phe 
945                 950                 955                 960


Asn Lys Glu Glu Leu Ser Ala Ile Leu Lys Phe Gly Ala Glu Glu Leu 
                965                 970                 975


Phe Lys Glu Pro Glu Gly Glu Glu Gln Glu Pro Gln Glu Met Asp Ile 
            980                 985                 990


Asp Glu Ile Leu Lys Arg Ala Glu Thr His Glu Asn Glu Pro Gly Pro 
        995                 1000                1005


Leu Thr Val Gly Asp Glu Leu Leu Ser Gln Phe Lys Val Ala Asn Phe 
    1010                1015                1020


Ser Asn Met Asp Glu Asp Asp Ile Glu Leu Glu Pro Glu Arg Asn Ser 
1025                1030                1035                1040


Lys Asn Trp Glu Glu Ile Ile Pro Glu Asp Gln Arg Arg Arg Leu Glu 
                1045                1050                1055


Glu Glu Glu Arg Gln Lys Glu Leu Glu Glu Ile Tyr Met Leu Pro Arg 
            1060                1065                1070


Met Arg Asn Cys Ala Lys Gln Ile Ser Phe Asn Gly Ser Glu Gly Arg 
        1075                1080                1085


Arg Ser Arg Ser Arg Arg Tyr Ser Gly Ser Asp Ser Asp Ser Ile Ser 
    1090                1095                1100


Glu Gly Lys Arg Pro Lys Lys Arg Gly Arg Pro Arg Thr Ile Pro Arg 
1105                1110                1115                1120


Glu Asn Ile Lys Gly Phe Ser Asp Ala Glu Ile Arg Arg Phe Ile Lys 
                1125                1130                1135


Ser Tyr Lys Lys Phe Gly Gly Pro Leu Glu Arg Leu Asp Ala Ile Ala 
            1140                1145                1150


Arg Asp Ala Glu Leu Val Asp Lys Ser Glu Thr Asp Leu Arg Arg Leu 
        1155                1160                1165


Gly Glu Leu Val His Asn Gly Cys Ile Lys Ala Leu Lys Asp Ser Ser 
    1170                1175                1180


Ser Gly Thr Glu Arg Thr Gly Gly Arg Leu Gly Lys Val Lys Gly Pro 
1185                1190                1195                1200


Thr Phe Arg Ile Ser Gly Val Gln Val Asn Ala Lys Leu Val Ile Ser 
                1205                1210                1215


His Glu Glu Glu Leu Ile Pro Leu His Lys Ser Ile Pro Ser Asp Pro 
            1220                1225                1230


Glu Glu Arg Lys Gln Tyr Thr Ile Pro Cys His Thr Lys Ala Ala His 
        1235                1240                1245


Phe Asp Ile Asp Trp Gly Lys Glu Asp Asp Ser Asn Leu Leu Ile Gly 
    1250                1255                1260


Ile Tyr Glu Tyr Gly Tyr Gly Ser Trp Glu Met Ile Lys Met Asp Pro 
1265                1270                1275                1280


Asp Leu Ser Leu Thr His Lys Ile Leu Pro Asp Asp Pro Asp Lys Lys 
                1285                1290                1295


Pro Gln Ala Lys Gln Leu Gln Thr Arg Ala Asp Tyr Leu Ile Lys Leu 
            1300                1305                1310


Leu Ser Arg Asp Leu Ala Lys Lys Glu Ala Leu Ser Gly Ala Gly Ser 
        1315                1320                1325


Ser Lys Arg Arg Lys Ala Arg Ala Lys Lys Asn Lys Ala Met Lys Ser 
    1330                1335                1340


Ile Lys Val Lys Glu Glu Ile Lys Ser Asp Ser Ser Pro Leu Pro Ser 
1345                1350                1355                1360


Glu Lys Ser Asp Glu Asp Asp Asp Lys Leu Ser Glu Ser Lys Ser Asp 
                1365                1370                1375


Gly Arg Glu Arg Ser Lys Lys Ser Ser Val Ser Asp Ala Pro Val His 
            1380                1385                1390


Ile Thr Ala Ser Gly Glu Pro Val Pro Ile Ser Glu Glu Ser Glu Glu 
        1395                1400                1405


Leu Asp Gln Lys Thr Phe Ser Ile Cys Lys Glu Arg Met Arg Pro Val 
    1410                1415                1420


Lys Ala Ala Leu Lys Gln Leu Asp Arg Pro Glu Lys Gly Leu Ser Glu 
1425                1430                1435                1440


Arg Glu Gln Leu Glu His Thr Arg Gln Cys Leu Ile Lys Ile Gly Asp 
                1445                1450                1455


His Ile Thr Glu Cys Leu Lys Glu Tyr Thr Asn Pro Glu Gln Ile Lys 
            1460                1465                1470


Gln Trp Arg Lys Asn Leu Trp Ile Phe Val Ser Lys Phe Thr Glu Phe 
        1475                1480                1485


Asp Ala Arg Lys Leu His Lys Leu Tyr Lys His Ala Ile Lys Lys Arg 
    1490                1495                1500


Gln Glu Ser Gln Gln Asn Ser Asp Gln Asn Ser Asn Leu Asn Pro His 
1505                1510                1515                1520


Val Ile Arg Asn Pro Asp Val Glu Arg Leu Lys Glu Asn Thr Asn His 
                1525                1530                1535


Asp Asp Ser Ser Arg Asp Ser Tyr Ser Ser Asp Arg His Leu Thr Gln 
            1540                1545                1550


Tyr His Asp His His Lys Asp Arg His Gln Gly Asp Ser Tyr Lys Lys 
        1555                1560                1565


Ser Asp Ser Arg Lys Arg Pro Tyr Ser Ser Phe Ser Asn Gly Lys Asp 
    1570                1575                1580


His Arg Asp Trp Asp His Tyr Lys Gln Asp Ser Arg Tyr Tyr Ser Asp 
1585                1590                1595                1600


Arg Glu Lys His Arg Lys Leu Asp Asp His Arg Ser Arg Asp His Arg 
                1605                1610                1615


Ser Asn Leu Glu Gly Ser Leu Lys Asp Arg Ser His Ser Asp His Arg 
            1620                1625                1630


Ser His Ser Asp His Arg Leu His Ser Asp His Arg Ser Ser Ser Glu 
        1635                1640                1645


Tyr Thr His His Lys Ser Ser Arg Asp Tyr Arg Tyr His Ser Asp Trp 
    1650                1655                1660


Gln Met Asp His Arg Ala Ser Ser Ser Gly Pro Arg Ser Pro Leu Asp 
1665                1670                1675                1680


Gln Arg Ser Pro Tyr Gly Ser Arg Ser Pro Phe Glu His Ser Val Glu 
                1685                1690                1695


His Lys Ser Thr Pro Glu His Thr Trp Ser Ser Arg Lys Thr 
            1700                1705                1710


<210>  2760
<211>  5930
<212>  DNA
<213>  Homo sapiens

<400>  2760
aggtgaatca aaggagagtc ccagaaaacc tgtgactgtt gaagaaaatt catctgtgaa     60

tttttatatt caaggagtca gtatttatat tcatctttta aactgggaag atttatattt    120

tactttaaaa cttcttgata ataatttaca atgaatggac acagtgatga agaaagtgtt    180

agaaacagta gtggagaatc aagccagtcg gatgatgatt ctgggtcagc ttcaggctct    240

ggatctggtt cgagttctgg aagcagtagt gatggaagca gtagccagtc aggtagcagt    300

gactctgact ccggatctga atcaggcagt cagtcagagt ctgagtcaga cacttcccga    360

gaaaacaaag ttcaagcaaa accaccgaaa gttgatggag ctgagttttg gaaatctagt    420

cctagtattc tggccgttca gagatctgca atcctcaaga agcagcaaca gcagcagcag    480

caacaacaac atcaagcctc atctaatagc ggatcagaag aggattcctc tagcagtgaa    540

gattccgatg actcatcaag tgaggtcaaa aggaaaaagc ataaagatga agattggcaa    600

atgtctgggt caggatctcc atctcagtct ggttcagatt cagaatctga agaagagaga    660

gagaaaagca gttgtgatga aacagaatct gattatgagc caaaaaacaa agtcaaaagc    720

agaaaacctc aaaatagatc taagtcaaaa aatggaaaga agattcttgg acaaaaaaag    780

agacagattg attcatctga ggaggatgat gatgaagaag attatgataa tgataaaaga    840

agttctcgtc gccaagcaac tgttaatgtt agctataagg aggatgaaga aatgaaaaca    900

gattctgatg acctactgga agtctgtgga gaggatgttc ctcaacctga ggaagaggaa    960

tttgaaacca tagaaagatt tatggattgt cggattggga gaaaaggagc tactggtgct   1020

actacaacca tctatgcagt tgaagcagat ggtgacccaa atgcaggctt tgaaaaaaac   1080

aaagaaccag gagagattca gtatttaatt aaatggaaag gatggtccca tatccacaac   1140

acttgggaga cagaagaaac cctcaagcag cagaatgtta gaggaatgaa aaaattggat   1200

aattataaga aaaaagatca ggaaacaaaa agatggttga aaaatgcctc tccagaagat   1260

gtggaatatt ataattgcca gcaagaactt acagatgatc tacataaaca gtatcaaata   1320

gtggaacgta taattgctca ttccaatcaa aagtcagcag ctggttatcc tgattattac   1380

tgcaaatggc agggccttcc atactcagag tgcagctggg aagatggagc tctcatttcc   1440

aaaaagtttc aagcatgcat tgatgagtat tttagcagga accaatcaaa aaccactcct   1500

tttaaagatt gcaaagtatt aaaacaaagg ccaaggtttg tagccctgaa gaagcagcca   1560

tcctatattg gaggacatga gggcttagaa ttaagagatt atcaactgaa tggtttaaat   1620

tggcttgctc attcttggtg caaaggaaat agttgcatac tcgctgatga aatgggcctt   1680

ggaaaaacaa tacagacgat ctcatttctg aattatttgt ttcatgaaca tcaattatat   1740

ggaccttttt tattggtagt accgctctcc actcttactt cctggcaaag ggaaattcag   1800

acttgggctt ctcaaatgaa tgctgtggtt tatttaggtg acattaacag cagaaacatg   1860

ataagaactc atgaatggac gcatcatcag accaaacggt taaaatttaa tatattgtta   1920

acaacttatg aaattttatt aaaagataag gcattccttg gaggtctaaa ttgggcattt   1980

ataggtgttg atgaagcaca ccgattaaag aatgatgact cccttctgta taaaacttta   2040

atagatttta aatccaatca tcgtctcctt atcactggaa ctcctctaca gaattccctc   2100

aaagagctct ggtctttgct acatttcatt atgccagaaa agttttcttc ctgggaagat   2160

tttgaagaag aacatggcaa agggagagaa tatggttatg caagccttca caaggagctt   2220

gagccatttc tgttacgccg agttaagaaa gatgtggaaa aatctcttcc tgccaaggtt   2280

gagcagattt taagaatgga aatgagtgct ttacagaaac aatattacaa atggatttta   2340

actaggaatt acaaagccct cagcaaaggt tccaagggca gtacctcagg ctttttgaac   2400

attatgatgg agctaaagaa atgttgtaac cattgctacc tcattaaacc accagataat   2460

aatgaattct ataataaaca ggaggcctta caacacttaa ttcgtagtag cggaaaattg   2520

attcttcttg acaagctatt aattcgccta agagaacgag gcaatcgagt tcttattttt   2580

tcacaaatgg tgcggatgtt agatatactt gcagaatatt tgaaatatcg tcaattcccc   2640

tttcaaagat tagatggatc aataaaagga gaactgagga aacaagctct agatcatttt   2700

aatgctgagg gatcagagga tttttgcttt ttgctgtcca caagagctgg aggtctaggg   2760

attaatttag cctctgctga cactgttgtt atatttgatt ccgattggaa tccacagaat   2820

gatcttcagg cacaggctag agcccatcga attgggcaaa agaaacaggt gaatatttat   2880

cgtctagtta caaagggatc agttgaagaa gatattcttg aaagggcgaa aaagaagatg   2940

gttttagatc atcttgtaat tcaaagaatg gacacaactg ggaagacagt actacataca   3000

ggttctgccc catcaagttc tactcctttc aataaagaag agttatcagc cattttaaag   3060

tttggtgctg aagaactttt taaggaacct gaaggagaag aacaagagcc ccaggaaatg   3120

gatatagatg aaatcttgaa gagagctgaa actcatgaaa atgaaccagg tcctttaact   3180

gtaggagatg aattgctttc ccagttcaag gttgccaact tctcaaatat ggatgaggat   3240

gacattgagt tggaacctga aagaaattca aagaattggg aggaaattat tccagaagat   3300

caaagaagac gattagaaga agaagaaaga caaaaggaac ttgaagaaat ttatatgctc   3360

ccaagaatga gaaattgtgc aaaacagatt agtttcaatg gaagtgaagg gaggcgcagt   3420

agaagtagga gatactctgg atctgatagt gattccatct cagaagggaa aaggccaaag   3480

aaacgtggaa gaccacggac tattcctcgg gagaatatta aaggatttag tgatgcagaa   3540

attaggcggt ttatcaagag ctataagaaa tttggtggtc ctctggaaag attagatgca   3600

attgctcgag atgctgagtt agttgataag tcagaaacag accttagacg actgggagaa   3660

ttggtacata atggttgcat taaagcatta aaggatagtt cttcaggaac agaacgaaca   3720

ggtggtagac tcggaaaagt gaagggtcca acattccgaa tatcaggagt acaggtgaat   3780

gccaaactag tcatctccca tgaagaagaa ttaatacctt tgcacaaatc cattccttct   3840

gatccagaag aaagaaagca gtatactatc ccatgccaca caaaggcagc tcattttgat   3900

atagactggg gcaaagaaga tgattccaat ttgttaattg gcatctatga atatggatat   3960

ggaagctggg aaatgattaa aatggatcct gacctcagtc taacacacaa gattcttcca   4020

gatgatcccg ataaaaaacc acaagcaaaa cagttgcaga cccgtgcaga ctacctcatc   4080

aaattactta gtagagatct tgcaaaaaaa gaagctcttt ctggtgcggg aagttcaaag   4140

aggagaaaag caagagctaa gaagaataaa gcaatgaagt ctataaaagt gaaagaggaa   4200

ataaagagtg attcttctcc tctgccttca gagaagtctg atgaagatga tgataaattg   4260

agtgaatcca agtctgatgg tagggaaaga tccaagaaat cttcagtgtc agatgctcca   4320

gttcatatca cggcaagtgg tgaaccagtt cccatttctg aagaatctga agagctggat   4380

cagaagacat tcagcatttg taaagaaaga atgaggcctg ttaaagcagc tttgaaacaa   4440

cttgataggc ctgagaaagg cctttcagaa agagaacaac tagagcatac tagacaatgt   4500

ttaataaaaa ttggagacca tatcacagaa tgtctaaaag agtatacaaa tcctgaacaa   4560

attaagcaat ggagaaaaaa cctgtggatt tttgtatcta agtttactga atttgatgca   4620

agaaaattac ataaattata taagcatgct attaaaaaac ggcaggagtc tcagcaaaac   4680

agtgatcaaa acagcaactt gaatcctcac gtgattagaa atccagatgt ggaaagatta   4740

aaagagaata caaatcacga tgatagcagc agggacagtt attcctctga tagacactta   4800

actcagtacc atgatcatca taaagaccga catcagggag attcttacaa aaaaagtgat   4860

tccaggaaaa gaccctattc ttcttttagt aatggtaaag accatcgtga ttgggatcac   4920

tacaagcaag acagcagata ttacagtgac agagagaaac acagaaaact ggatgatcac   4980

aggagtagag atcacaggtc aaatttggaa ggaagtttaa aagatagatc tcattctgat   5040

catcgttctc actcagatca tcggttacat tcagaccacc ggtcaagttc tgaatatacg   5100

caccataaat cttccaggga ttataggtat cactcagact ggcaaatgga ccacagagct   5160

tccagcagtg gccctaggtc accactagat cagagatctc cttatggctc cagatctcca   5220

tttgaacatt cagttgaaca caaaagtaca ccggagcata cctggagtag tcggaaaaca   5280

taacaaaaac tgatacttcg tctttctgga cttttctttt agccatatat cataaaccaa   5340

cacagtaatt gccttacatg acttgaaaga tataaacaga tcttctatca gtagcagtat   5400

tgttacttct ttccaggatg caaggtctat tatcccaaca gaagagaaaa tatttttata   5460

tttaaggatt atgctgcact gtactacaaa attgtagtac ttttttttgt tttctttttt   5520

aaagaaatgg aaaatgttta ctattacagg gacctcaaca ctgccctccc atacaggctg   5580

gataaaactg tttttaagtc agtgatttta gactgacctc catttaaatt atgtttatat   5640

atgaacttta ctctgacctg tgatcatgtt tcaggaagga atgaaagaga gttctttctt   5700

aataaagaaa aacactcaag gactttgttc atttccaaag ctacttgttt acattgtaca   5760

ctgcgaccac cttgccgctt ttcatcacaa gcttgaatat ttaaattctg tacttatatc   5820

tgtaaaatag ccaggaattt cctgtttgtg atctattatg cctttttaca aaaaaaatgg   5880

ctgtaaatta ttgtaaatat taaaggaact ttccttactt ccttcccttt              5930


<210>  2761
<211>  1710
<212>  PRT
<213>  Homo sapiens

<400>  2761

Met Asn Gly His Ser Asp Glu Glu Ser Val Arg Asn Ser Ser Gly Glu 
1               5                   10                  15


Ser Ser Gln Ser Asp Asp Asp Ser Gly Ser Ala Ser Gly Ser Gly Ser 
            20                  25                  30


Gly Ser Ser Ser Gly Ser Ser Ser Asp Gly Ser Ser Ser Gln Ser Gly 
        35                  40                  45


Ser Ser Asp Ser Asp Ser Gly Ser Glu Ser Gly Ser Gln Ser Glu Ser 
    50                  55                  60


Glu Ser Asp Thr Ser Arg Glu Asn Lys Val Gln Ala Lys Pro Pro Lys 
65                  70                  75                  80


Val Asp Gly Ala Glu Phe Trp Lys Ser Ser Pro Ser Ile Leu Ala Val 
                85                  90                  95


Gln Arg Ser Ala Ile Leu Lys Lys Gln Gln Gln Gln Gln Gln Gln Gln 
            100                 105                 110


Gln His Gln Ala Ser Ser Asn Ser Gly Ser Glu Glu Asp Ser Ser Ser 
        115                 120                 125


Ser Glu Asp Ser Asp Asp Ser Ser Ser Glu Val Lys Arg Lys Lys His 
    130                 135                 140


Lys Asp Glu Asp Trp Gln Met Ser Gly Ser Gly Ser Pro Ser Gln Ser 
145                 150                 155                 160


Gly Ser Asp Ser Glu Ser Glu Glu Glu Arg Glu Lys Ser Ser Cys Asp 
                165                 170                 175


Glu Thr Glu Ser Asp Tyr Glu Pro Lys Asn Lys Val Lys Ser Arg Lys 
            180                 185                 190


Pro Gln Asn Arg Ser Lys Ser Lys Asn Gly Lys Lys Ile Leu Gly Gln 
        195                 200                 205


Lys Lys Arg Gln Ile Asp Ser Ser Glu Glu Asp Asp Asp Glu Glu Asp 
    210                 215                 220


Tyr Asp Asn Asp Lys Arg Ser Ser Arg Arg Gln Ala Thr Val Asn Val 
225                 230                 235                 240


Ser Tyr Lys Glu Asp Glu Glu Met Lys Thr Asp Ser Asp Asp Leu Leu 
                245                 250                 255


Glu Val Cys Gly Glu Asp Val Pro Gln Pro Glu Glu Glu Glu Phe Glu 
            260                 265                 270


Thr Ile Glu Arg Phe Met Asp Cys Arg Ile Gly Arg Lys Gly Ala Thr 
        275                 280                 285


Gly Ala Thr Thr Thr Ile Tyr Ala Val Glu Ala Asp Gly Asp Pro Asn 
    290                 295                 300


Ala Gly Phe Glu Lys Asn Lys Glu Pro Gly Glu Ile Gln Tyr Leu Ile 
305                 310                 315                 320


Lys Trp Lys Gly Trp Ser His Ile His Asn Thr Trp Glu Thr Glu Glu 
                325                 330                 335


Thr Leu Lys Gln Gln Asn Val Arg Gly Met Lys Lys Leu Asp Asn Tyr 
            340                 345                 350


Lys Lys Lys Asp Gln Glu Thr Lys Arg Trp Leu Lys Asn Ala Ser Pro 
        355                 360                 365


Glu Asp Val Glu Tyr Tyr Asn Cys Gln Gln Glu Leu Thr Asp Asp Leu 
    370                 375                 380


His Lys Gln Tyr Gln Ile Val Glu Arg Ile Ile Ala His Ser Asn Gln 
385                 390                 395                 400


Lys Ser Ala Ala Gly Tyr Pro Asp Tyr Tyr Cys Lys Trp Gln Gly Leu 
                405                 410                 415


Pro Tyr Ser Glu Cys Ser Trp Glu Asp Gly Ala Leu Ile Ser Lys Lys 
            420                 425                 430


Phe Gln Ala Cys Ile Asp Glu Tyr Phe Ser Arg Asn Gln Ser Lys Thr 
        435                 440                 445


Thr Pro Phe Lys Asp Cys Lys Val Leu Lys Gln Arg Pro Arg Phe Val 
    450                 455                 460


Ala Leu Lys Lys Gln Pro Ser Tyr Ile Gly Gly His Glu Gly Leu Glu 
465                 470                 475                 480


Leu Arg Asp Tyr Gln Leu Asn Gly Leu Asn Trp Leu Ala His Ser Trp 
                485                 490                 495


Cys Lys Gly Asn Ser Cys Ile Leu Ala Asp Glu Met Gly Leu Gly Lys 
            500                 505                 510


Thr Ile Gln Thr Ile Ser Phe Leu Asn Tyr Leu Phe His Glu His Gln 
        515                 520                 525


Leu Tyr Gly Pro Phe Leu Leu Val Val Pro Leu Ser Thr Leu Thr Ser 
    530                 535                 540


Trp Gln Arg Glu Ile Gln Thr Trp Ala Ser Gln Met Asn Ala Val Val 
545                 550                 555                 560


Tyr Leu Gly Asp Ile Asn Ser Arg Asn Met Ile Arg Thr His Glu Trp 
                565                 570                 575


Thr His His Gln Thr Lys Arg Leu Lys Phe Asn Ile Leu Leu Thr Thr 
            580                 585                 590


Tyr Glu Ile Leu Leu Lys Asp Lys Ala Phe Leu Gly Gly Leu Asn Trp 
        595                 600                 605


Ala Phe Ile Gly Val Asp Glu Ala His Arg Leu Lys Asn Asp Asp Ser 
    610                 615                 620


Leu Leu Tyr Lys Thr Leu Ile Asp Phe Lys Ser Asn His Arg Leu Leu 
625                 630                 635                 640


Ile Thr Gly Thr Pro Leu Gln Asn Ser Leu Lys Glu Leu Trp Ser Leu 
                645                 650                 655


Leu His Phe Ile Met Pro Glu Lys Phe Ser Ser Trp Glu Asp Phe Glu 
            660                 665                 670


Glu Glu His Gly Lys Gly Arg Glu Tyr Gly Tyr Ala Ser Leu His Lys 
        675                 680                 685


Glu Leu Glu Pro Phe Leu Leu Arg Arg Val Lys Lys Asp Val Glu Lys 
    690                 695                 700


Ser Leu Pro Ala Lys Val Glu Gln Ile Leu Arg Met Glu Met Ser Ala 
705                 710                 715                 720


Leu Gln Lys Gln Tyr Tyr Lys Trp Ile Leu Thr Arg Asn Tyr Lys Ala 
                725                 730                 735


Leu Ser Lys Gly Ser Lys Gly Ser Thr Ser Gly Phe Leu Asn Ile Met 
            740                 745                 750


Met Glu Leu Lys Lys Cys Cys Asn His Cys Tyr Leu Ile Lys Pro Pro 
        755                 760                 765


Asp Asn Asn Glu Phe Tyr Asn Lys Gln Glu Ala Leu Gln His Leu Ile 
    770                 775                 780


Arg Ser Ser Gly Lys Leu Ile Leu Leu Asp Lys Leu Leu Ile Arg Leu 
785                 790                 795                 800


Arg Glu Arg Gly Asn Arg Val Leu Ile Phe Ser Gln Met Val Arg Met 
                805                 810                 815


Leu Asp Ile Leu Ala Glu Tyr Leu Lys Tyr Arg Gln Phe Pro Phe Gln 
            820                 825                 830


Arg Leu Asp Gly Ser Ile Lys Gly Glu Leu Arg Lys Gln Ala Leu Asp 
        835                 840                 845


His Phe Asn Ala Glu Gly Ser Glu Asp Phe Cys Phe Leu Leu Ser Thr 
    850                 855                 860


Arg Ala Gly Gly Leu Gly Ile Asn Leu Ala Ser Ala Asp Thr Val Val 
865                 870                 875                 880


Ile Phe Asp Ser Asp Trp Asn Pro Gln Asn Asp Leu Gln Ala Gln Ala 
                885                 890                 895


Arg Ala His Arg Ile Gly Gln Lys Lys Gln Val Asn Ile Tyr Arg Leu 
            900                 905                 910


Val Thr Lys Gly Ser Val Glu Glu Asp Ile Leu Glu Arg Ala Lys Lys 
        915                 920                 925


Lys Met Val Leu Asp His Leu Val Ile Gln Arg Met Asp Thr Thr Gly 
    930                 935                 940


Lys Thr Val Leu His Thr Gly Ser Ala Pro Ser Ser Ser Thr Pro Phe 
945                 950                 955                 960


Asn Lys Glu Glu Leu Ser Ala Ile Leu Lys Phe Gly Ala Glu Glu Leu 
                965                 970                 975


Phe Lys Glu Pro Glu Gly Glu Glu Gln Glu Pro Gln Glu Met Asp Ile 
            980                 985                 990


Asp Glu Ile Leu Lys Arg Ala Glu Thr His Glu Asn Glu Pro Gly Pro 
        995                 1000                1005


Leu Thr Val Gly Asp Glu Leu Leu Ser Gln Phe Lys Val Ala Asn Phe 
    1010                1015                1020


Ser Asn Met Asp Glu Asp Asp Ile Glu Leu Glu Pro Glu Arg Asn Ser 
1025                1030                1035                1040


Lys Asn Trp Glu Glu Ile Ile Pro Glu Asp Gln Arg Arg Arg Leu Glu 
                1045                1050                1055


Glu Glu Glu Arg Gln Lys Glu Leu Glu Glu Ile Tyr Met Leu Pro Arg 
            1060                1065                1070


Met Arg Asn Cys Ala Lys Gln Ile Ser Phe Asn Gly Ser Glu Gly Arg 
        1075                1080                1085


Arg Ser Arg Ser Arg Arg Tyr Ser Gly Ser Asp Ser Asp Ser Ile Ser 
    1090                1095                1100


Glu Gly Lys Arg Pro Lys Lys Arg Gly Arg Pro Arg Thr Ile Pro Arg 
1105                1110                1115                1120


Glu Asn Ile Lys Gly Phe Ser Asp Ala Glu Ile Arg Arg Phe Ile Lys 
                1125                1130                1135


Ser Tyr Lys Lys Phe Gly Gly Pro Leu Glu Arg Leu Asp Ala Ile Ala 
            1140                1145                1150


Arg Asp Ala Glu Leu Val Asp Lys Ser Glu Thr Asp Leu Arg Arg Leu 
        1155                1160                1165


Gly Glu Leu Val His Asn Gly Cys Ile Lys Ala Leu Lys Asp Ser Ser 
    1170                1175                1180


Ser Gly Thr Glu Arg Thr Gly Gly Arg Leu Gly Lys Val Lys Gly Pro 
1185                1190                1195                1200


Thr Phe Arg Ile Ser Gly Val Gln Val Asn Ala Lys Leu Val Ile Ser 
                1205                1210                1215


His Glu Glu Glu Leu Ile Pro Leu His Lys Ser Ile Pro Ser Asp Pro 
            1220                1225                1230


Glu Glu Arg Lys Gln Tyr Thr Ile Pro Cys His Thr Lys Ala Ala His 
        1235                1240                1245


Phe Asp Ile Asp Trp Gly Lys Glu Asp Asp Ser Asn Leu Leu Ile Gly 
    1250                1255                1260


Ile Tyr Glu Tyr Gly Tyr Gly Ser Trp Glu Met Ile Lys Met Asp Pro 
1265                1270                1275                1280


Asp Leu Ser Leu Thr His Lys Ile Leu Pro Asp Asp Pro Asp Lys Lys 
                1285                1290                1295


Pro Gln Ala Lys Gln Leu Gln Thr Arg Ala Asp Tyr Leu Ile Lys Leu 
            1300                1305                1310


Leu Ser Arg Asp Leu Ala Lys Lys Glu Ala Leu Ser Gly Ala Gly Ser 
        1315                1320                1325


Ser Lys Arg Arg Lys Ala Arg Ala Lys Lys Asn Lys Ala Met Lys Ser 
    1330                1335                1340


Ile Lys Val Lys Glu Glu Ile Lys Ser Asp Ser Ser Pro Leu Pro Ser 
1345                1350                1355                1360


Glu Lys Ser Asp Glu Asp Asp Asp Lys Leu Ser Glu Ser Lys Ser Asp 
                1365                1370                1375


Gly Arg Glu Arg Ser Lys Lys Ser Ser Val Ser Asp Ala Pro Val His 
            1380                1385                1390


Ile Thr Ala Ser Gly Glu Pro Val Pro Ile Ser Glu Glu Ser Glu Glu 
        1395                1400                1405


Leu Asp Gln Lys Thr Phe Ser Ile Cys Lys Glu Arg Met Arg Pro Val 
    1410                1415                1420


Lys Ala Ala Leu Lys Gln Leu Asp Arg Pro Glu Lys Gly Leu Ser Glu 
1425                1430                1435                1440


Arg Glu Gln Leu Glu His Thr Arg Gln Cys Leu Ile Lys Ile Gly Asp 
                1445                1450                1455


His Ile Thr Glu Cys Leu Lys Glu Tyr Thr Asn Pro Glu Gln Ile Lys 
            1460                1465                1470


Gln Trp Arg Lys Asn Leu Trp Ile Phe Val Ser Lys Phe Thr Glu Phe 
        1475                1480                1485


Asp Ala Arg Lys Leu His Lys Leu Tyr Lys His Ala Ile Lys Lys Arg 
    1490                1495                1500


Gln Glu Ser Gln Gln Asn Ser Asp Gln Asn Ser Asn Leu Asn Pro His 
1505                1510                1515                1520


Val Ile Arg Asn Pro Asp Val Glu Arg Leu Lys Glu Asn Thr Asn His 
                1525                1530                1535


Asp Asp Ser Ser Arg Asp Ser Tyr Ser Ser Asp Arg His Leu Thr Gln 
            1540                1545                1550


Tyr His Asp His His Lys Asp Arg His Gln Gly Asp Ser Tyr Lys Lys 
        1555                1560                1565


Ser Asp Ser Arg Lys Arg Pro Tyr Ser Ser Phe Ser Asn Gly Lys Asp 
    1570                1575                1580


His Arg Asp Trp Asp His Tyr Lys Gln Asp Ser Arg Tyr Tyr Ser Asp 
1585                1590                1595                1600


Arg Glu Lys His Arg Lys Leu Asp Asp His Arg Ser Arg Asp His Arg 
                1605                1610                1615


Ser Asn Leu Glu Gly Ser Leu Lys Asp Arg Ser His Ser Asp His Arg 
            1620                1625                1630


Ser His Ser Asp His Arg Leu His Ser Asp His Arg Ser Ser Ser Glu 
        1635                1640                1645


Tyr Thr His His Lys Ser Ser Arg Asp Tyr Arg Tyr His Ser Asp Trp 
    1650                1655                1660


Gln Met Asp His Arg Ala Ser Ser Ser Gly Pro Arg Ser Pro Leu Asp 
1665                1670                1675                1680


Gln Arg Ser Pro Tyr Gly Ser Arg Ser Pro Phe Glu His Ser Val Glu 
                1685                1690                1695


His Lys Ser Thr Pro Glu His Thr Trp Ser Ser Arg Lys Thr 
            1700                1705                1710


<210>  2762
<211>  293
<212>  DNA
<213>  Homo sapiens

<400>  2762
gattgcctca actctaagga ttgaactgat attgaagttt cattttaatt aattacaaag     60

tgcatcgtaa agtttcaaac agtaaagttt tactagaatc accagagttg aggtttaatt    120

aaaagacttt tgaatctgag ctttgattca aatctctata ggtatgttga ctactgacta    180

tagttaagta aatagaagag tcatattgtc cacccacaat tttttttttc ttttcttttc    240

ttttgagaca gggcctcatc cagcctggga aacaagtgaa actccgtctc aaa           293


<210>  2763
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  2763

Val Asn Arg Arg Val Ile Leu Ser Thr His Asn Phe Phe Phe Leu Phe 
1               5                   10                  15


Phe Ser Phe Glu Thr Gly Pro His Pro Ala Trp Glu Thr Ser Glu Thr 
            20                  25                  30


Pro Ser 



<210>  2764
<211>  205
<212>  DNA
<213>  Homo sapiens

<400>  2764
gagccgactc gggtggacgg cctcccccgc gcccaggccc gggatctccg ccgcccagtc     60

ctagggctcc ggcgtctcgg gagctactat gttatgatat ctcaaactaa tatttgagac    120

tccttggctt gataactatg attccattga agatgactat tgagttgaat ggctctgttt    180

tccatcaacg atgacagctt ttaat                                          205


<210>  2765
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  2765

Ala Asp Ser Gly Gly Arg Pro Pro Pro Arg Pro Gly Pro Gly Ser Pro 
1               5                   10                  15


Pro Pro Ser Pro Arg Ala Pro Ala Ser Arg Glu Leu Leu Cys Tyr Asp 
            20                  25                  30


Ile Ser Asn 
        35


<210>  2766
<211>  2103
<212>  DNA
<213>  Homo sapiens

<400>  2766
cccggaccca ggtgctgcca gggcggcggc tggcggccgg cttctcgctc gggcagcggc     60

ggcggcggcg gcggcggctt ccggagtccc gctgcgaaga tgctcaaagt cacggtgccc    120

tcctgctccg cctcgtcctg ctcttcggtc accgccagtg cggccccggg gaccgcgagc    180

ctcgtcccgg attactggat cgacggctcc aacagggatg cgctgagcga tttcttcgag    240

gtggagtcgg agctgggacg gggtgctaca tccattgtgt acagatgcaa acagaagggg    300

acccagaagc cttatgctct caaagtgtta aagaaaacag tggacaaaaa aatcgtaaga    360

actgagatag gagttcttct tcgcctctca catccaaaca ttataaaact taaagagata    420

tttgaaaccc ctacagaaat cagtctggtc ctagaactcg tcacaggagg agaactgttt    480

gataggattg tggaaaaggg atattacagt gagcgagatg ctgcagatgc cgttaaacaa    540

atcctggagg cagttgctta tctacatgaa aatgggattg tccatcgtga tctcaaacca    600

gagaatcttc tttatgcaac tccagcccca gatgcaccac tcaaaatcgc tgattttgga    660

ctctctaaaa ttgtggaaca tcaagtgctc atgaagacag tatgtggaac cccagggtac    720

tgcgcacctg aaattcttag aggttgtgcc tatggacctg aggtggacat gtggtctgta    780

ggaataatca cctacatctt actttgtgga tttgaaccat tctatgatga aagaggcgat    840

cagttcatgt tcaggagaat tctgaattgt gaatattact ttatctcccc ctggtgggat    900

gaagtatctc taaatgccaa ggacttggtc agaaaattaa ttgttttgga tccaaagaaa    960

cggctgacta catttcaagc tctccagcat ccgtgggtca caggtaaagc agccaatttt   1020

gtacacatgg ataccgctca aaagaagctc caagaattca atgcccggcg taagcttaag   1080

gcagcggtga aggctgtggt ggcctcttcg cgcctgggaa gtgccagcag cagccatggc   1140

agcatccagg agagccacaa ggctagccga gacccttctc caatccaaga tggcaacgag   1200

gacatgaaag ctattccaga aggagagaaa attcaaggcg atggggccca agccgcagtt   1260

aagggggcac aggctgagct gatgaaggtg caagccttag agaaagttaa aggtgcagat   1320

ataaatgctg aagaggcccc caaaatggtg cccaaggcag tggaggatgg gataaaggtg   1380

gctgacctgg aactagagga gggcctagca gaggagaagc tgaagactgt ggaggaggca   1440

gcagctccca gagaagggca aggaagctct gctgtgggtt ttgaagttcc acagcaagat   1500

gtgatcctgc cagagtacta aacagcttcc ttcagatctg gaagccaaac accggcattt   1560

tatgtacttt gtccttcagc aagaaaggtg tggaagcatg atatgtacta tagtgattct   1620

gtttttgagg tgcaaaaaac atacatatat accagttggt aattctaact tcaatgcatg   1680

tgactgcttt atgaaaataa tagtgtcttc tatggcatgt aatggatacc taataccgat   1740

gagttaaatc ttgcaagtta acacaacgta acacttaaaa gcatacattt tcagcaacca   1800

gtggcacata tttgaagtga atagtagcaa attgtttttg ctttgaaaat ctagccatcc   1860

tacatccttt ggatttcttc acaaggcagt aattcctttg aactactgct tagctaatac   1920

taggtagtgc taaaagacat gttcccataa cttttacaac attttacttt ttatcattga   1980

tgtgttcaaa ctgtttacaa ggagatgctt atagatgata gttgtacata tgtgcaaaaa   2040

aaaatccact tgcaatggta agaaattgaa gtatccttaa aggccatgaa gccatatgtc   2100

cct                                                                 2103


<210>  2767
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  2767

Met Leu Lys Val Thr Val Pro Ser Cys Ser Ala Ser Ser Cys Ser Ser 
1               5                   10                  15


Val Thr Ala Ser Ala Ala Pro Gly Thr Ala Ser Leu Val Pro Asp Tyr 
            20                  25                  30


Trp Ile Asp Gly Ser Asn Arg Asp Ala Leu Ser Asp Phe Phe Glu Val 
        35                  40                  45


Glu Ser Glu Leu Gly Arg Gly Ala Thr Ser Ile Val Tyr Arg Cys Lys 
    50                  55                  60


Gln Lys Gly Thr Gln Lys Pro Tyr Ala Leu Lys Val Leu Lys Lys Thr 
65                  70                  75                  80


Val Asp Lys Lys Ile Val Arg Thr Glu Ile Gly Val Leu Leu Arg Leu 
                85                  90                  95


Ser His Pro Asn Ile Ile Lys Leu Lys Glu Ile Phe Glu Thr Pro Thr 
            100                 105                 110


Glu Ile Ser Leu Val Leu Glu Leu Val Thr Gly Gly Glu Leu Phe Asp 
        115                 120                 125


Arg Ile Val Glu Lys Gly Tyr Tyr Ser Glu Arg Asp Ala Ala Asp Ala 
    130                 135                 140


Val Lys Gln Ile Leu Glu Ala Val Ala Tyr Leu His Glu Asn Gly Ile 
145                 150                 155                 160


Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Tyr Ala Thr Pro Ala 
                165                 170                 175


Pro Asp Ala Pro Leu Lys Ile Ala Asp Phe Gly Leu Ser Lys Ile Val 
            180                 185                 190


Glu His Gln Val Leu Met Lys Thr Val Cys Gly Thr Pro Gly Tyr Cys 
        195                 200                 205


Ala Pro Glu Ile Leu Arg Gly Cys Ala Tyr Gly Pro Glu Val Asp Met 
    210                 215                 220


Trp Ser Val Gly Ile Ile Thr Tyr Ile Leu Leu Cys Gly Phe Glu Pro 
225                 230                 235                 240


Phe Tyr Asp Glu Arg Gly Asp Gln Phe Met Phe Arg Arg Ile Leu Asn 
                245                 250                 255


Cys Glu Tyr Tyr Phe Ile Ser Pro Trp Trp Asp Glu Val Ser Leu Asn 
            260                 265                 270


Ala Lys Asp Leu Val Arg Lys Leu Ile Val Leu Asp Pro Lys Lys Arg 
        275                 280                 285


Leu Thr Thr Phe Gln Ala Leu Gln His Pro Trp Val Thr Gly Lys Ala 
    290                 295                 300


Ala Asn Phe Val His Met Asp Thr Ala Gln Lys Lys Leu Gln Glu Phe 
305                 310                 315                 320


Asn Ala Arg Arg Lys Leu Lys Ala Ala Val Lys Ala Val Val Ala Ser 
                325                 330                 335


Ser Arg Leu Gly Ser Ala Ser Ser Ser His Gly Ser Ile Gln Glu Ser 
            340                 345                 350


His Lys Ala Ser Arg Asp Pro Ser Pro Ile Gln Asp Gly Asn Glu Asp 
        355                 360                 365


Met Lys Ala Ile Pro Glu Gly Glu Lys Ile Gln Gly Asp Gly Ala Gln 
    370                 375                 380


Ala Ala Val Lys Gly Ala Gln Ala Glu Leu Met Lys Val Gln Ala Leu 
385                 390                 395                 400


Glu Lys Val Lys Gly Ala Asp Ile Asn Ala Glu Glu Ala Pro Lys Met 
                405                 410                 415


Val Pro Lys Ala Val Glu Asp Gly Ile Lys Val Ala Asp Leu Glu Leu 
            420                 425                 430


Glu Glu Gly Leu Ala Glu Glu Lys Leu Lys Thr Val Glu Glu Ala Ala 
        435                 440                 445


Ala Pro Arg Glu Gly Gln Gly Ser Ser Ala Val Gly Phe Glu Val Pro 
    450                 455                 460


Gln Gln Asp Val Ile Leu Pro Glu Tyr 
465                 470


<210>  2768
<211>  6524
<212>  DNA
<213>  Homo sapiens

<400>  2768
cccggaccca ggtgctgcca gggcggcggc tggcggccgg cttctcgctc gggcagcggc     60

ggcggcggcg gcggcggctt ccggagtccc gctgcgaaga tgctcaaagt cacggtgccc    120

tcctgctccg cctcgtcctg ctcttcggtc accgccagtg cggccccggg gaccgcgagc    180

ctcgtcccgg attactggat cgacggctcc aacagggatg cgctgagcga tttcttcgag    240

gtggagtcgg agctgggacg gggtgctaca tccattgtgt acagatgcaa acagaagggg    300

acccagaagc cttatgctct caaagtgtta aagaaaacag tggacaaaaa aatcgtaaga    360

actgagatag gagttcttct tcgcctctca catccaaaca ttataaaact taaagagata    420

tttgaaaccc ctacagaaat cagtctggtc ctagaactcg tcacaggagg agaactgttt    480

gataggattg tggaaaaggg atattacagt gagcgagatg ctgcagatgc cgttaaacaa    540

atcctggagg cagttgctta tctacatgaa aatgggattg tccatcgtga tctcaaacca    600

gagaatcttc tttatgcaac tccagcccca gatgcaccac tcaaaatcgc tgattttgga    660

ctctctaaaa ttgtggaaca tcaagtgctc atgaagacag tatgtggaac cccagggtac    720

tgcgcacctg aaattcttag aggttgtgcc tatggacctg aggtggacat gtggtctgta    780

ggaataatca cctacatctt actttgtgga tttgaaccat tctatgatga aagaggcgat    840

cagttcatgt tcaggagaat tctgaattgt gaatattact ttatctcccc ctggtgggat    900

gaagtatctc taaatgccaa ggacttggtc agaaaattaa ttgttttgga tccaaagaaa    960

cggctgacta catttcaagc tctccagcat ccgtgggtca caggtaaagc agccaatttt   1020

gtacacatgg ataccgctca aaagaagctc caagaattca atgcccggcg taagcttaag   1080

gcagcggtga aggctgtggt ggcctcttcg cgcctgggaa gtgccagcag cagccatggc   1140

agcatccagg agagccacaa ggctagccga gacccttctc caatccaaga tggcaacgag   1200

gacatgaaag ctattccaga aggagagaaa attcaaggcg atggggccca agccgcagtt   1260

aagggggcac aggctgagct gatgaaggtg caagccttag agaaagttaa aggtgcagat   1320

ataaatgctg aagaggcccc caaaatggtg cccaaggcag tggaggatgg gataaaggtg   1380

gctgacctgg aactagagga gggcctagca gaggagaagc tgaagactgt ggaggaggca   1440

gcagctccca gagaagggca aggaagctct gctgtgggtt ttgaagttcc acagcaagat   1500

gtgatcctgc cagagtacta aacagcttcc ttcagatctg gaagccaaac accggcattt   1560

tatgtacttt gtccttcagc aagaaaggtg tggaagcatg atatgtacta tagtgattct   1620

gtttttgagg tgcaaaaaac atacatatat accagttggt aattctaact tcaatgcatg   1680

tgactgcttt atgaaaataa tagtgtcttc tatggcatgt aatggatacc taataccgat   1740

gagttaaatc ttgcaagtta acacaacgta acacttaaaa gcatacattt tcagcaacca   1800

gtggcacata tttgaagtga atagtagcaa attgtttttg ctttgaaaat ctagccatcc   1860

tacatccttt ggatttcttc acaaggcagt aattcctttg aactactgct tagctaatac   1920

taggtagtgc taaaagacat gttcccataa cttttacaac attttacttt ttatcattga   1980

tgtgttcaaa ctgtttacaa ggagatgctt atagatgata gttgtacata tgtgcaaaaa   2040

aaaatccact tgcaatggta agaaattgaa gtatccttaa aggccatgaa gccatatgtc   2100

cctaaagcct gtgtggagaa tgctttattt tattcttatt tatatacact atattaataa   2160

taaccaaaat gttctaagat tctgccattt tacaaccctg gaggaagtaa tttacaaact   2220

cacgctgagt tccattcttt ccttcacctg ctctccaata agatgacttt ctgatagaca   2280

aagcttaggg tgtaataaac agggaagaaa agaaggtaag actgtactta aactgatgaa   2340

gataagattg attccttttc attttccaga taaaattgta tttactcatg aatttataca   2400

actttacaga taagaacatt ttaatggata aactctataa ttaccaagtt gcaaatattt   2460

agaaaattct atttcacagg ttagtgccaa aatgtcttca tagagtagga ataatattcc   2520

attttaagat tattcattat tgactttaat agagtaagaa aacattattg tttatcaaag   2580

ctcttttttt atccaattga tggttatcta cacatatcac ttataaacta aagttattta   2640

tgaaaagcta gtatgtcttt ttctcgtatt tggaatgaaa gtacccacat tttacaatgt   2700

agtgttgaga atgtggctgc caataaattt agcacaatgc aatttattta ccttaaaaaa   2760

caaacaaaaa caaaaataaa gaaaaatact gatttcaaat cagactctta aaaagctgga   2820

acattagacc tgatatttta ttatgatttt tcccagaata agtttaattt ctctttgact   2880

ttcatagaaa cactttcccc ttatagaaat tgcactatct ccaatttatt tctagtttga   2940

gttgaaatga atattttatc agattaatta tgtgtcacat ttttggtggg ttttctcaat   3000

tttaaaaaag aattcatttt aaaaaataat tattttcaga gaccaaataa agacaataaa   3060

aatgactatc acataaaaat ccttgttaaa aaagagatct taaattatgt tggctctccc   3120

tcaaaactat taaattagaa aacgaaacta aagctccagt ttgtagaggc tgttggacct   3180

cagtagacat tcttcttttc aatcacaaat ctctctctac tactgttctc atgggaagaa   3240

aacaaggtag gacttcttat ctttcatagt ttaagaatct gacaggtcac tgatatggag   3300

cccctgaaga agcacatcat ctgggctcag aagattattt tttgttttgt tttatttgta   3360

ctatctagta gagagcactt ttcttattcc ctctttcctt ccttcctcat ttaattattc   3420

cctctcagaa ttcccatgtt gtccattata aggggctcgc tatttttaac ctttaagaat   3480

gtcttctttg ttaagcatta agatttccat ttaagaggat caatttcctg ttgtactttt   3540

taccatgaga ctgaaacaca cacacacaca cacacacaca cacacacaca cacacacgtg   3600

ttggaagagc aaagagaggg aagggggtct ttttagaaag tggcacttgg cgcttagctg   3660

aaagatcaga acacatcatt cctccctgcc cacccccata ttgttccaag ggcagttgtt   3720

acattatttc aacactagag tagggcggac tgcattgttt ggccctgaga actatagaaa   3780

caacgttgca aataccatgc ccaatgtgta ttttagaatt tactcattta aatgagtgca   3840

tattaccatt cctccatgtg agtactcgag ttgataattc cctctatctt tttaaaccca   3900

taaactacat ttttaaaaaa atcaatggga gttttaaatt ttgactcatg ttaaagataa   3960

gattctgata atgactatat agtgactaat ttcattgttt cagtaggaaa caaatcaaac   4020

tttcaaaaat gttggtcatt tcagtcaaat tattcaaaga tttcatatac atacatccta   4080

agttaggata attatgttaa catttttgaa agaacagcca atgtttatat tgcttgttaa   4140

aatggaatgt attgtctatc tcaaagatta cttagctaaa taatagtaga caaatggaga   4200

tttaatttca caaaatactt cataacatca ctcctaattg gcaatatagt cacaaagcaa   4260

aagaattcaa atttcagcaa acaataaatt acattttaca ttttagagct aacacttatc   4320

acattacatt atgggttttt attttgagat aagttcagct acatagcata aactaggttt   4380

ttttttataa ccatgaagga cagtcttgaa ttatttcccc cattaacaaa gtctaattgg   4440

aatccagtat tttttctcaa actgtaattt cacttgtccc aggacacata aataggtaaa   4500

aattagaata atatcgtggt agaagttaat tgtccagaac aagtgcatta tataaatata   4560

atgcaagcac atgtcattta agattttcta ttagtcacat tttaagaaaa atagatgaaa   4620

gtatagtatt tttaatccaa ttcatccaaa ttattctatc gatatatagt caatattaaa   4680

atttaatgtg atattttgaa ttctttattt ttatactgtt ttcaaaatca agagtgtatg   4740

ttaggccttt gggacatcaa gtgctcaata gtcacatgtg gctagtggct accatattag   4800

acagcactag tctagagtac tttttatttt aagcaaagtg acacttgaag ttctatgctt   4860

agatttaagt ggcctcagtt ttcacattga ggagctggtg ggaggccaca aagaaagtgt   4920

ttcagaaatg ttacacactg agtaaaagct tattgaccac tcctgcccat tcatttactt   4980

cagaggagaa atgattccta acatgacttc aaagaacggg cattactaaa ttatctactg   5040

accaatccct ctgattcctg atgggccctg gagtcttgac tacagcctag agtctcctga   5100

gtactgccat gatgccaata gcattcttgc ttaccaaaat ctactctcag ccaactatgt   5160

gtcttcattc aggaagaact gcacatagaa tctgattttg aggcctggat taagcttcat   5220

gccatccttg tatcacaggc aatatgtctt tctggaaatc taatgaacca taccaaatct   5280

gcatgatgaa gattgtgtaa tgatggtgat atcatgccag ttatcctcaa agtgggaata   5340

tgaccattag ctggcatttt ttaagatttc cttagaaggg tttaatcaac actgccatta   5400

cacatggatt taacaaaaga cttttgaaaa ttttttacat actgatttta gaataatcct   5460

caaggttcta tagtcatttt tagtggaaga cttaaaaaga aaggaacaat ttttactgtg   5520

acttcaattt catagtattt taaacatatt ttgtaattca gaatgtttag caatccctat   5580

gtcctgtttc acatgcatgg taactgatgg tgggttgcct acaggctgaa gatttggaga   5640

gagccatttt gtttcataaa tcagttttta ttgcacagaa gcagctggtt gtatttcaag   5700

ttggaaaaag aaaagtaaat gccagaaaag gcaaaggata aacttagtaa gccatttatt   5760

ttgttttaga attgtttttg caaagcaaat ttttttaaaa aaaggtcaac aaagtgaatc   5820

agcactagca ttttcttgat ggttgactca atgtataatt aacaaatata catagcagag   5880

tcaattaatc atagtgccat tatgtcactt atttgtcatt gcaaagtatt cagtcatgtt   5940

gtctagattt actttagatg gtgcaaaatt tccagatagt aacctatgta aaaggatttg   6000

taatttcctt gtaattcctg cctattagtc catattctga tttccttatg ttcatcactg   6060

atatgttcct gatcagggtc attgctagta gttgagcatt tactggttga acattgttta   6120

atggttagat gttatgtgtg tctgcattta aaaaaattgt gtacatgtta tttcactatt   6180

ggtattacaa tattcataac cacatgataa acagaaatgt acccaataat ttcctataaa   6240

atttttcaaa gtccttttat tcccctgaca cactcagggt gaatttttgt ctccttggca   6300

aataagaaaa aaaaggagag agaccactgg agagatatca gcaaaccacc cacagtaacc   6360

aagttcagta tttcctcttt ctatattttg accaatatat taagagcaaa ttttgtcatt   6420

attactcctt gtggctatta cctgagatca gataatataa tctcagctca taaagcttgg   6480

ccatgtctat acttatcttg gagagcaata acaaacttga ttaa                    6524


<210>  2769
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  2769

Met Leu Lys Val Thr Val Pro Ser Cys Ser Ala Ser Ser Cys Ser Ser 
1               5                   10                  15


Val Thr Ala Ser Ala Ala Pro Gly Thr Ala Ser Leu Val Pro Asp Tyr 
            20                  25                  30


Trp Ile Asp Gly Ser Asn Arg Asp Ala Leu Ser Asp Phe Phe Glu Val 
        35                  40                  45


Glu Ser Glu Leu Gly Arg Gly Ala Thr Ser Ile Val Tyr Arg Cys Lys 
    50                  55                  60


Gln Lys Gly Thr Gln Lys Pro Tyr Ala Leu Lys Val Leu Lys Lys Thr 
65                  70                  75                  80


Val Asp Lys Lys Ile Val Arg Thr Glu Ile Gly Val Leu Leu Arg Leu 
                85                  90                  95


Ser His Pro Asn Ile Ile Lys Leu Lys Glu Ile Phe Glu Thr Pro Thr 
            100                 105                 110


Glu Ile Ser Leu Val Leu Glu Leu Val Thr Gly Gly Glu Leu Phe Asp 
        115                 120                 125


Arg Ile Val Glu Lys Gly Tyr Tyr Ser Glu Arg Asp Ala Ala Asp Ala 
    130                 135                 140


Val Lys Gln Ile Leu Glu Ala Val Ala Tyr Leu His Glu Asn Gly Ile 
145                 150                 155                 160


Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Tyr Ala Thr Pro Ala 
                165                 170                 175


Pro Asp Ala Pro Leu Lys Ile Ala Asp Phe Gly Leu Ser Lys Ile Val 
            180                 185                 190


Glu His Gln Val Leu Met Lys Thr Val Cys Gly Thr Pro Gly Tyr Cys 
        195                 200                 205


Ala Pro Glu Ile Leu Arg Gly Cys Ala Tyr Gly Pro Glu Val Asp Met 
    210                 215                 220


Trp Ser Val Gly Ile Ile Thr Tyr Ile Leu Leu Cys Gly Phe Glu Pro 
225                 230                 235                 240


Phe Tyr Asp Glu Arg Gly Asp Gln Phe Met Phe Arg Arg Ile Leu Asn 
                245                 250                 255


Cys Glu Tyr Tyr Phe Ile Ser Pro Trp Trp Asp Glu Val Ser Leu Asn 
            260                 265                 270


Ala Lys Asp Leu Val Arg Lys Leu Ile Val Leu Asp Pro Lys Lys Arg 
        275                 280                 285


Leu Thr Thr Phe Gln Ala Leu Gln His Pro Trp Val Thr Gly Lys Ala 
    290                 295                 300


Ala Asn Phe Val His Met Asp Thr Ala Gln Lys Lys Leu Gln Glu Phe 
305                 310                 315                 320


Asn Ala Arg Arg Lys Leu Lys Ala Ala Val Lys Ala Val Val Ala Ser 
                325                 330                 335


Ser Arg Leu Gly Ser Ala Ser Ser Ser His Gly Ser Ile Gln Glu Ser 
            340                 345                 350


His Lys Ala Ser Arg Asp Pro Ser Pro Ile Gln Asp Gly Asn Glu Asp 
        355                 360                 365


Met Lys Ala Ile Pro Glu Gly Glu Lys Ile Gln Gly Asp Gly Ala Gln 
    370                 375                 380


Ala Ala Val Lys Gly Ala Gln Ala Glu Leu Met Lys Val Gln Ala Leu 
385                 390                 395                 400


Glu Lys Val Lys Gly Ala Asp Ile Asn Ala Glu Glu Ala Pro Lys Met 
                405                 410                 415


Val Pro Lys Ala Val Glu Asp Gly Ile Lys Val Ala Asp Leu Glu Leu 
            420                 425                 430


Glu Glu Gly Leu Ala Glu Glu Lys Leu Lys Thr Val Glu Glu Ala Ala 
        435                 440                 445


Ala Pro Arg Glu Gly Gln Gly Ser Ser Ala Val Gly Phe Glu Val Pro 
    450                 455                 460


Gln Gln Asp Val Ile Leu Pro Glu Tyr 
465                 470


<210>  2770
<211>  2559
<212>  DNA
<213>  Homo sapiens

<400>  2770
cacaggcaat ttatatattt gtctatatct agggtcacaa aagtggcgag tggcataacc     60

agggcttgaa cacacttcct gactcccaat agtctctgcc tcatatcagg tcacccctac    120

taagcccagg actgtggatt attttatttg ctgaccttcc tgggaattta ttgactgccc    180

atcctcacaa gcaggggtaa acctccaaga atgggctgcc attgattgga ttccattctt    240

taggcaaatc atgccctcaa gccactgact tcttggatta taaaatgatt tttaaactct    300

gggcttagtc cttcaagtac cctcaagggg ttagaaagaa ctataaaccc caagatagaa    360

acataaggta gtattccata agttctggga tactctccct tttgtttgcc atttaatccc    420

cacagaaaga atgatgatgc atgaatgatt ccattctgtt accatagaga tgtactttaa    480

gttctgaatt ctaggtgatt gtgaagcgca gcccagaatt attttgctgg ttctgccttc    540

aaagaacttc cagtccacag gcaagtgagg agctgtttct tgacttctgt tggaaagccg    600

tctgccactt tgggggtctc aggtggtaca tggccctgtc ttctcatact ccctcagcta    660

ctgctacctg aagctgtgcc tacctacagt ggcccctgag gacttaaaca atttttttct    720

cacatatatt tagtggtact gctgggaaat ggaataagat ctggaagttt gtaagctgag    780

ggcaagccca ggtcatccta aaaacctcgc taagtttatg gttctttatt atttcaggtc    840

agaaaattaa ttgttttgga tccaaagaaa cggctgacta catttcaagc tctccagcat    900

ccgtgggtca caggtaaagc agccaatttt gtacacatgg ataccgctca aaagaagctc    960

caagaattca atgcccggcg taagcttaag gcagcggtga aggctgtggt ggcctcttcg   1020

cgcctgggaa gtgccagcag cagccatggc agcatccagg agagccacaa ggctagccga   1080

gacccttctc caatccaaga tggcaacgag gacatgaaag ctattccaga aggagagaaa   1140

attcaaggcg atggggccca agccgcagtt aagggggcac aggctgagct gatgaaggtg   1200

caagccttag agaaagttaa aggtgcagat ataaatgctg aagaggcccc caaaatggtg   1260

cccaaggcag tggaggatgg gataaaggtg gctgacctgg aactagagga gggcctagca   1320

gaggagaagc tgaagactgt ggaggaggca gcagctccca gagaagggca aggaagctct   1380

gctgtgggtt ttgaagttcc acagcaagat gtgatcctgc cagagtacta aacagcttcc   1440

ttcagatctg gaagccaaac accggcattt tatgtacttt gtccttcagc aagaaaggtg   1500

tggaagcatg atatgtacta tagtgattct gtttttgagg tgcaaaaaac atacatatat   1560

accagttggt aattctaact tcaatgcatg tgactgcttt atgaaaataa tagtgtcttc   1620

tatggcatgt aatggatacc taataccgat gagttaaatc ttgcaagtta acacaacgta   1680

acacttaaaa gcatacattt tcagcaacca gtggcacata tttgaagtga atagtagcaa   1740

attgtttttg ctttgaaaat ctagccatcc tacatccttt ggatttcttc acaaggcagt   1800

aattcctttg aactactgct tagctaatac taggtagtgc taaaagacat gttcccataa   1860

cttttacaac attttacttt ttatcattga tgtgttcaaa ctgtttacaa ggagatgctt   1920

atagatgata gttgtacata tgtgcaaaaa aaaatccact tgcaatggta agaaattgaa   1980

gtatccttaa aggccatgaa gccatatgtc cctaaagcct gtgtggagaa tgctttattt   2040

tattcttatt tatatacact atattaataa taaccaaaat gttctaagat tctgccattt   2100

tacaaccctg gaggaagtaa tttacaaact cacgctgagt tccattcttt ccttcacctg   2160

ctctccaata agatgacttt ctgatagaca aagcttaggg tgtaataaac agggaagaaa   2220

agaaggtaag actgtactta aactgatgaa gataagattg attccttttc attttccaga   2280

taaaattgta tttactcatg aatttataca actttacaga taagaacatt ttaatggata   2340

aactctataa ttaccaagtt gcaaatattt agaaaattct atttcacagg ttagtgccaa   2400

aatgtcttca tagagtagga ataatattcc attttaagat tattcattat tgactttaat   2460

agagtaagaa aacattattg tttatcaaag ctcttttttt atccaattga tggttatcta   2520

cacatatcac ttataaacta aagttattta tgaaaagct                          2559


<210>  2771
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  2771

Met Asp Thr Ala Gln Lys Lys Leu Gln Glu Phe Asn Ala Arg Arg Lys 
1               5                   10                  15


Leu Lys Ala Ala Val Lys Ala Val Val Ala Ser Ser Arg Leu Gly Ser 
            20                  25                  30


Ala Ser Ser Ser His Gly Ser Ile Gln Glu Ser His Lys Ala Ser Arg 
        35                  40                  45


Asp Pro Ser Pro Ile Gln Asp Gly Asn Glu Asp Met Lys Ala Ile Pro 
    50                  55                  60


Glu Gly Glu Lys Ile Gln Gly Asp Gly Ala Gln Ala Ala Val Lys Gly 
65                  70                  75                  80


Ala Gln Ala Glu Leu Met Lys Val Gln Ala Leu Glu Lys Val Lys Gly 
                85                  90                  95


Ala Asp Ile Asn Ala Glu Glu Ala Pro Lys Met Val Pro Lys Ala Val 
            100                 105                 110


Glu Asp Gly Ile Lys Val Ala Asp Leu Glu Leu Glu Glu Gly Leu Ala 
        115                 120                 125


Glu Glu Lys Leu Lys Thr Val Glu Glu Ala Ala Ala Pro Arg Glu Gly 
    130                 135                 140


Gln Gly Ser Ser Ala Val Gly Phe Glu Val Pro Gln Gln Asp Val Ile 
145                 150                 155                 160


Leu Pro Glu Tyr 



<210>  2772
<211>  5652
<212>  DNA
<213>  Homo sapiens

<400>  2772
agcgcagccc agaattattt tgctggttct gccttcaaag aacttccagt ccacaggcaa     60

aaaattaatt gttttggatc caaagaaacg gctgactaca tttcaagctc tccagcatcc    120

gtgggtcaca ggtaaagcag ccaattttgt acacatggat accgctcaaa agaagctcca    180

agaattcaat gcccggcgta agcttaaggc agcggtgaag gctgtggtgg cctcttcgcg    240

cctgggaagt gccagcagca gccatggcag catccaggag agccacaagg ctagccgaga    300

cccttctcca atccaagatg gcaacgagga catgaaagct attccagaag gagagaaaat    360

tcaaggcgat ggggcccaag ccgcagttaa gggggcacag gctgagctga tgaaggtgca    420

agccttagag aaagttaaag gtgcagatat aaatgctgaa gaggccccca aaatggtgcc    480

caaggcagtg gaggatggga taaaggtggc tgacctggaa ctagaggagg gcctagcaga    540

ggagaagctg aagactgtgg aggaggcagc agctcccaga gaagggcaag gaagctctgc    600

tgtgggtttt gaagttccac agcaagatgt gatcctgcca gagtactaaa cagcttcctt    660

cagatctgga agccaaacac cggcatttta tgtactttgt ccttcagcaa gaaaggtgtg    720

gaagcatgat atgtactata gtgattctgt ttttgaggtg caaaaaacat acatatatac    780

cagttggtaa ttctaacttc aatgcatgtg actgctttat gaaaataata gtgtcttcta    840

tggcatgtaa tggataccta ataccgatga gttaaatctt gcaagttaac acaacgtaac    900

acttaaaagc atacattttc agcaaccagt ggcacatatt tgaagtgaat agtagcaaat    960

tgtttttgct ttgaaaatct agccatccta catcctttgg atttcttcac aaggcagtaa   1020

ttcctttgaa ctactgctta gctaatacta ggtagtgcta aaagacatgt tcccataact   1080

tttacaacat tttacttttt atcattgatg tgttcaaact gtttacaagg agatgcttat   1140

agatgatagt tgtacatatg tgcaaaaaaa aatccacttg caatggtaag aaattgaagt   1200

atccttaaag gccatgaagc catatgtccc taaagcctgt gtggagaatg ctttatttta   1260

ttcttattta tatacactat attaataata accaaaatgt tctaagattc tgccatttta   1320

caaccctgga ggaagtaatt tacaaactca cgctgagttc cattctttcc ttcacctgct   1380

ctccaataag atgactttct gatagacaaa gcttagggtg taataaacag ggaagaaaag   1440

aaggtaagac tgtacttaaa ctgatgaaga taagattgat tccttttcat tttccagata   1500

aaattgtatt tactcatgaa tttatacaac tttacagata agaacatttt aatggataaa   1560

ctctataatt accaagttgc aaatatttag aaaattctat ttcacaggtt agtgccaaaa   1620

tgtcttcata gagtaggaat aatattccat tttaagatta ttcattattg actttaatag   1680

agtaagaaaa cattattgtt tatcaaagct ctttttttat ccaattgatg gttatctaca   1740

catatcactt ataaactaaa gttatttatg aaaagctagt atgtcttttt ctcgtatttg   1800

gaatgaaagt acccacattt tacaatgtag tgttgagaat gtggctgcca ataaatttag   1860

cacaatgcaa tttatttacc ttaaaaaaca aacaaaaaca aaaataaaga aaaatactga   1920

tttcaaatca gactcttaaa aagctggaac attagacctg atattttatt atgatttttc   1980

ccagaataag tttaatttct ctttgacttt catagaaaca ctttcccctt atagaaattg   2040

cactatctcc aatttatttc tagtttgagt tgaaatgaat attttatcag attaattatg   2100

tgtcacattt ttggtgggtt ttctcaattt taaaaaagaa ttcattttaa aaaataatta   2160

ttttcagaga ccaaataaag acaataaaaa tgactatcac ataaaaatcc ttgttaaaaa   2220

agagatctta aattatgttg gctctccctc aaaactatta aattagaaaa cgaaactaaa   2280

gctccagttt gtagaggctg ttggacctca gtagacattc ttcttttcaa tcacaaatct   2340

ctctctacta ctgttctcat gggaagaaaa caaggtagga cttcttatct ttcatagttt   2400

aagaatctga caggtcactg atatggagcc cctgaagaag cacatcatct gggctcagaa   2460

gattattttt tgttttgttt tatttgtact atctagtaga gagcactttt cttattccct   2520

ctttccttcc ttcctcattt aattattccc tctcagaatt cccatgttgt ccattataag   2580

gggctcgcta tttttaacct ttaagaatgt cttctttgtt aagcattaag atttccattt   2640

aagaggatca atttcctgtt gtacttttta ccatgagact gaaacacaca cacacacaca   2700

cacacacaca cacacacaca cacacgtgtt ggaagagcaa agagagggaa gggggtcttt   2760

ttagaaagtg gcacttggcg cttagctgaa agatcagaac acatcattcc tccctgccca   2820

cccccatatt gttccaaggg cagttgttac attatttcaa cactagagta gggcggactg   2880

cattgtttgg ccctgagaac tatagaaaca acgttgcaaa taccatgccc aatgtgtatt   2940

ttagaattta ctcatttaaa tgagtgcata ttaccattcc tccatgtgag tactcgagtt   3000

gataattccc tctatctttt taaacccata aactacattt ttaaaaaaat caatgggagt   3060

tttaaatttt gactcatgtt aaagataaga ttctgataat gactatatag tgactaattt   3120

cattgtttca gtaggaaaca aatcaaactt tcaaaaatgt tggtcatttc agtcaaatta   3180

ttcaaagatt tcatatacat acatcctaag ttaggataat tatgttaaca tttttgaaag   3240

aacagccaat gtttatattg cttgttaaaa tggaatgtat tgtctatctc aaagattact   3300

tagctaaata atagtagaca aatggagatt taatttcaca aaatacttca taacatcact   3360

cctaattggc aatatagtca caaagcaaaa gaattcaaat ttcagcaaac aataaattac   3420

attttacatt ttagagctaa cacttatcac attacattat gggtttttat tttgagataa   3480

gttcagctac atagcataaa ctaggttttt ttttataacc atgaaggaca gtcttgaatt   3540

atttccccca ttaacaaagt ctaattggaa tccagtattt tttctcaaac tgtaatttca   3600

cttgtcccag gacacataaa taggtaaaaa ttagaataat atcgtggtag aagttaattg   3660

tccagaacaa gtgcattata taaatataat gcaagcacat gtcatttaag attttctatt   3720

agtcacattt taagaaaaat agatgaaagt atagtatttt taatccaatt catccaaatt   3780

attctatcga tatatagtca atattaaaat ttaatgtgat attttgaatt ctttattttt   3840

atactgtttt caaaatcaag agtgtatgtt aggcctttgg gacatcaagt gctcaatagt   3900

cacatgtggc tagtggctac catattagac agcactagtc tagagtactt tttattttaa   3960

gcaaagtgac acttgaagtt ctatgcttag atttaagtgg cctcagtttt cacattgagg   4020

agctggtggg aggccacaaa gaaagtgttt cagaaatgtt acacactgag taaaagctta   4080

ttgaccactc ctgcccattc atttacttca gaggagaaat gattcctaac atgacttcaa   4140

agaacgggca ttactaaatt atctactgac caatccctct gattcctgat gggccctgga   4200

gtcttgacta cagcctagag tctcctgagt actgccatga tgccaatagc attcttgctt   4260

accaaaatct actctcagcc aactatgtgt cttcattcag gaagaactgc acatagaatc   4320

tgattttgag gcctggatta agcttcatgc catccttgta tcacaggcaa tatgtctttc   4380

tggaaatcta atgaaccata ccaaatctgc atgatgaaga ttgtgtaatg atggtgatat   4440

catgccagtt atcctcaaag tgggaatatg accattagct ggcatttttt aagatttcct   4500

tagaagggtt taatcaacac tgccattaca catggattta acaaaagact tttgaaaatt   4560

ttttacatac tgattttaga ataatcctca aggttctata gtcattttta gtggaagact   4620

taaaaagaaa ggaacaattt ttactgtgac ttcaatttca tagtatttta aacatatttt   4680

gtaattcaga atgtttagca atccctatgt cctgtttcac atgcatggta actgatggtg   4740

ggttgcctac aggctgaaga tttggagaga gccattttgt ttcataaatc agtttttatt   4800

gcacagaagc agctggttgt atttcaagtt ggaaaaagaa aagtaaatgc cagaaaaggc   4860

aaaggataaa cttagtaagc catttatttt gttttagaat tgtttttgca aagcaaattt   4920

ttttaaaaaa aggtcaacaa agtgaatcag cactagcatt ttcttgatgg ttgactcaat   4980

gtataattaa caaatataca tagcagagtc aattaatcat agtgccatta tgtcacttat   5040

ttgtcattgc aaagtattca gtcatgttgt ctagatttac tttagatggt gcaaaatttc   5100

cagatagtaa cctatgtaaa aggatttgta atttccttgt aattcctgcc tattagtcca   5160

tattctgatt tccttatgtt catcactgat atgttcctga tcagggtcat tgctagtagt   5220

tgagcattta ctggttgaac attgtttaat ggttagatgt tatgtgtgtc tgcatttaaa   5280

aaaattgtgt acatgttatt tcactattgg tattacaata ttcataacca catgataaac   5340

agaaatgtac ccaataattt cctataaaat ttttcaaagt ccttttattc ccctgacaca   5400

ctcagggtga atttttgtct ccttggcaaa taagaaaaaa aaggagagag accactggag   5460

agatatcagc aaaccaccca cagtaaccaa gttcagtatt tcctctttct atattttgac   5520

caatatatta agagcaaatt ttgtcattat tactccttgt ggctattacc tgagatcaga   5580

taatataatc tcagctcata aagcttggcc atgtctatac ttatcttgga gagcaataac   5640

aaacttgatt aa                                                       5652


<210>  2773
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  2773

Met Asp Thr Ala Gln Lys Lys Leu Gln Glu Phe Asn Ala Arg Arg Lys 
1               5                   10                  15


Leu Lys Ala Ala Val Lys Ala Val Val Ala Ser Ser Arg Leu Gly Ser 
            20                  25                  30


Ala Ser Ser Ser His Gly Ser Ile Gln Glu Ser His Lys Ala Ser Arg 
        35                  40                  45


Asp Pro Ser Pro Ile Gln Asp Gly Asn Glu Asp Met Lys Ala Ile Pro 
    50                  55                  60


Glu Gly Glu Lys Ile Gln Gly Asp Gly Ala Gln Ala Ala Val Lys Gly 
65                  70                  75                  80


Ala Gln Ala Glu Leu Met Lys Val Gln Ala Leu Glu Lys Val Lys Gly 
                85                  90                  95


Ala Asp Ile Asn Ala Glu Glu Ala Pro Lys Met Val Pro Lys Ala Val 
            100                 105                 110


Glu Asp Gly Ile Lys Val Ala Asp Leu Glu Leu Glu Glu Gly Leu Ala 
        115                 120                 125


Glu Glu Lys Leu Lys Thr Val Glu Glu Ala Ala Ala Pro Arg Glu Gly 
    130                 135                 140


Gln Gly Ser Ser Ala Val Gly Phe Glu Val Pro Gln Gln Asp Val Ile 
145                 150                 155                 160


Leu Pro Glu Tyr 



<210>  2774
<211>  5554
<212>  DNA
<213>  Homo sapiens

<400>  2774
catttcaagc tctccagcat ccgtgggtca caggtaaagc agccaatttt gtacacatgg     60

ataccgctca aaagaagctc caagaattca atgcccggcg taagcttaag gcagcggtga    120

aggctgtggt ggcctcttcg cgcctgggaa gtgccagcag cagccatggc agcatccagg    180

agagccacaa ggctagccga gacccttctc caatccaaga tggcaacgag gacatgaaag    240

ctattccaga aggagagaaa attcaaggcg atggggccca agccgcagtt aagggggcac    300

aggctgagct gatgaaggtg caagccttag agaaagttaa aggtgcagat ataaatgctg    360

aagaggcccc caaaatggtg cccaaggcag tggaggatgg gataaaggtg gctgacctgg    420

aactagagga gggcctagca gaggagaagc tgaagactgt ggaggaggca gcagctccca    480

gagaagggca aggaagctct gctgtgggtt ttgaagttcc acagcaagat gtgatcctgc    540

cagagtacta aacagcttcc ttcagatctg gaagccaaac accggcattt tatgtacttt    600

gtccttcagc aagaaaggtg tggaagcatg atatgtacta tagtgattct gtttttgagg    660

tgcaaaaaac atacatatat accagttggt aattctaact tcaatgcatg tgactgcttt    720

atgaaaataa tagtgtcttc tatggcatgt aatggatacc taataccgat gagttaaatc    780

ttgcaagtta acacaacgta acacttaaaa gcatacattt tcagcaacca gtggcacata    840

tttgaagtga atagtagcaa attgtttttg ctttgaaaat ctagccatcc tacatccttt    900

ggatttcttc acaaggcagt aattcctttg aactactgct tagctaatac taggtagtgc    960

taaaagacat gttcccataa cttttacaac attttacttt ttatcattga tgtgttcaaa   1020

ctgtttacaa ggagatgctt atagatgata gttgtacata tgtgcaaaaa aaaatccact   1080

tgcaatggta agaaattgaa gtatccttaa aggccatgaa gccatatgtc cctaaagcct   1140

gtgtggagaa tgctttattt tattcttatt tatatacact atattaataa taaccaaaat   1200

gttctaagat tctgccattt tacaaccctg gaggaagtaa tttacaaact cacgctgagt   1260

tccattcttt ccttcacctg ctctccaata agatgacttt ctgatagaca aagcttaggg   1320

tgtaataaac agggaagaaa agaaggtaag actgtactta aactgatgaa gataagattg   1380

attccttttc attttccaga taaaattgta tttactcatg aatttataca actttacaga   1440

taagaacatt ttaatggata aactctataa ttaccaagtt gcaaatattt agaaaattct   1500

atttcacagg ttagtgccaa aatgtcttca tagagtagga ataatattcc attttaagat   1560

tattcattat tgactttaat agagtaagaa aacattattg tttatcaaag ctcttttttt   1620

atccaattga tggttatcta cacatatcac ttataaacta aagttattta tgaaaagcta   1680

gtatgtcttt ttctcgtatt tggaatgaaa gtacccacat tttacaatgt agtgttgaga   1740

atgtggctgc caataaattt agcacaatgc aatttattta ccttaaaaaa caaacaaaaa   1800

caaaaataaa gaaaaatact gatttcaaat cagactctta aaaagctgga acattagacc   1860

tgatatttta ttatgatttt tcccagaata agtttaattt ctctttgact ttcatagaaa   1920

cactttcccc ttatagaaat tgcactatct ccaatttatt tctagtttga gttgaaatga   1980

atattttatc agattaatta tgtgtcacat ttttggtggg ttttctcaat tttaaaaaag   2040

aattcatttt aaaaaataat tattttcaga gaccaaataa agacaataaa aatgactatc   2100

acataaaaat ccttgttaaa aaagagatct taaattatgt tggctctccc tcaaaactat   2160

taaattagaa aacgaaacta aagctccagt ttgtagaggc tgttggacct cagtagacat   2220

tcttcttttc aatcacaaat ctctctctac tactgttctc atgggaagaa aacaaggtag   2280

gacttcttat ctttcatagt ttaagaatct gacaggtcac tgatatggag cccctgaaga   2340

agcacatcat ctgggctcag aagattattt tttgttttgt tttatttgta ctatctagta   2400

gagagcactt ttcttattcc ctctttcctt ccttcctcat ttaattattc cctctcagaa   2460

ttcccatgtt gtccattata aggggctcgc tatttttaac ctttaagaat gtcttctttg   2520

ttaagcatta agatttccat ttaagaggat caatttcctg ttgtactttt taccatgaga   2580

ctgaaacaca cacacacaca cacacacaca cacacacaca cacacacgtg ttggaagagc   2640

aaagagaggg aagggggtct ttttagaaag tggcacttgg cgcttagctg aaagatcaga   2700

acacatcatt cctccctgcc cacccccata ttgttccaag ggcagttgtt acattatttc   2760

aacactagag tagggcggac tgcattgttt ggccctgaga actatagaaa caacgttgca   2820

aataccatgc ccaatgtgta ttttagaatt tactcattta aatgagtgca tattaccatt   2880

cctccatgtg agtactcgag ttgataattc cctctatctt tttaaaccca taaactacat   2940

ttttaaaaaa atcaatggga gttttaaatt ttgactcatg ttaaagataa gattctgata   3000

atgactatat agtgactaat ttcattgttt cagtaggaaa caaatcaaac tttcaaaaat   3060

gttggtcatt tcagtcaaat tattcaaaga tttcatatac atacatccta agttaggata   3120

attatgttaa catttttgaa agaacagcca atgtttatat tgcttgttaa aatggaatgt   3180

attgtctatc tcaaagatta cttagctaaa taatagtaga caaatggaga tttaatttca   3240

caaaatactt cataacatca ctcctaattg gcaatatagt cacaaagcaa aagaattcaa   3300

atttcagcaa acaataaatt acattttaca ttttagagct aacacttatc acattacatt   3360

atgggttttt attttgagat aagttcagct acatagcata aactaggttt ttttttataa   3420

ccatgaagga cagtcttgaa ttatttcccc cattaacaaa gtctaattgg aatccagtat   3480

tttttctcaa actgtaattt cacttgtccc aggacacata aataggtaaa aattagaata   3540

atatcgtggt agaagttaat tgtccagaac aagtgcatta tataaatata atgcaagcac   3600

atgtcattta agattttcta ttagtcacat tttaagaaaa atagatgaaa gtatagtatt   3660

tttaatccaa ttcatccaaa ttattctatc gatatatagt caatattaaa atttaatgtg   3720

atattttgaa ttctttattt ttatactgtt ttcaaaatca agagtgtatg ttaggccttt   3780

gggacatcaa gtgctcaata gtcacatgtg gctagtggct accatattag acagcactag   3840

tctagagtac tttttatttt aagcaaagtg acacttgaag ttctatgctt agatttaagt   3900

ggcctcagtt ttcacattga ggagctggtg ggaggccaca aagaaagtgt ttcagaaatg   3960

ttacacactg agtaaaagct tattgaccac tcctgcccat tcatttactt cagaggagaa   4020

atgattccta acatgacttc aaagaacggg cattactaaa ttatctactg accaatccct   4080

ctgattcctg atgggccctg gagtcttgac tacagcctag agtctcctga gtactgccat   4140

gatgccaata gcattcttgc ttaccaaaat ctactctcag ccaactatgt gtcttcattc   4200

aggaagaact gcacatagaa tctgattttg aggcctggat taagcttcat gccatccttg   4260

tatcacaggc aatatgtctt tctggaaatc taatgaacca taccaaatct gcatgatgaa   4320

gattgtgtaa tgatggtgat atcatgccag ttatcctcaa agtgggaata tgaccattag   4380

ctggcatttt ttaagatttc cttagaaggg tttaatcaac actgccatta cacatggatt   4440

taacaaaaga cttttgaaaa ttttttacat actgatttta gaataatcct caaggttcta   4500

tagtcatttt tagtggaaga cttaaaaaga aaggaacaat ttttactgtg acttcaattt   4560

catagtattt taaacatatt ttgtaattca gaatgtttag caatccctat gtcctgtttc   4620

acatgcatgg taactgatgg tgggttgcct acaggctgaa gatttggaga gagccatttt   4680

gtttcataaa tcagttttta ttgcacagaa gcagctggtt gtatttcaag ttggaaaaag   4740

aaaagtaaat gccagaaaag gcaaaggata aacttagtaa gccatttatt ttgttttaga   4800

attgtttttg caaagcaaat ttttttaaaa aaaggtcaac aaagtgaatc agcactagca   4860

ttttcttgat ggttgactca atgtataatt aacaaatata catagcagag tcaattaatc   4920

atagtgccat tatgtcactt atttgtcatt gcaaagtatt cagtcatgtt gtctagattt   4980

actttagatg gtgcaaaatt tccagatagt aacctatgta aaaggatttg taatttcctt   5040

gtaattcctg cctattagtc catattctga tttccttatg ttcatcactg atatgttcct   5100

gatcagggtc attgctagta gttgagcatt tactggttga acattgttta atggttagat   5160

gttatgtgtg tctgcattta aaaaaattgt gtacatgtta tttcactatt ggtattacaa   5220

tattcataac cacatgataa acagaaatgt acccaataat ttcctataaa atttttcaaa   5280

gtccttttat tcccctgaca cactcagggt gaatttttgt ctccttggca aataagaaaa   5340

aaaaggagag agaccactgg agagatatca gcaaaccacc cacagtaacc aagttcagta   5400

tttcctcttt ctatattttg accaatatat taagagcaaa ttttgtcatt attactcctt   5460

gtggctatta cctgagatca gataatataa tctcagctca taaagcttgg ccatgtctat   5520

acttatcttg gagagcaata acaaacttga ttaa                               5554


<210>  2775
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  2775

Met Asp Thr Ala Gln Lys Lys Leu Gln Glu Phe Asn Ala Arg Arg Lys 
1               5                   10                  15


Leu Lys Ala Ala Val Lys Ala Val Val Ala Ser Ser Arg Leu Gly Ser 
            20                  25                  30


Ala Ser Ser Ser His Gly Ser Ile Gln Glu Ser His Lys Ala Ser Arg 
        35                  40                  45


Asp Pro Ser Pro Ile Gln Asp Gly Asn Glu Asp Met Lys Ala Ile Pro 
    50                  55                  60


Glu Gly Glu Lys Ile Gln Gly Asp Gly Ala Gln Ala Ala Val Lys Gly 
65                  70                  75                  80


Ala Gln Ala Glu Leu Met Lys Val Gln Ala Leu Glu Lys Val Lys Gly 
                85                  90                  95


Ala Asp Ile Asn Ala Glu Glu Ala Pro Lys Met Val Pro Lys Ala Val 
            100                 105                 110


Glu Asp Gly Ile Lys Val Ala Asp Leu Glu Leu Glu Glu Gly Leu Ala 
        115                 120                 125


Glu Glu Lys Leu Lys Thr Val Glu Glu Ala Ala Ala Pro Arg Glu Gly 
    130                 135                 140


Gln Gly Ser Ser Ala Val Gly Phe Glu Val Pro Gln Gln Asp Val Ile 
145                 150                 155                 160


Leu Pro Glu Tyr 



<210>  2776
<211>  460
<212>  DNA
<213>  Homo sapiens

<400>  2776
ttttggtggt ttcttaaatg atttattatc gtattctaca tgccaactgc tttacatttc     60

ccagcagcaa gatataggct tctttgggca tgttctgaca tgtctgtctg agtgaactta    120

caccaagtaa cattggccct caggtcaaat ttctacaatt agtcttccaa cacccatttt    180

ttataatgtc acgtactctt caagttccta gaaaacaccc cccaaccccc cccaaaattt    240

acatatttaa ttactgaatt gggttatcca acctgaatcc aagaagaagc cacagctctc    300

atgtggtctg cctcaggctt tgggcagctg agacagccca tgactgttgt gtcccatgat    360

ttttgtaacc tcacagtaat tctacttctc ttccatcatt caaatgacag tcaatcttgc    420

tccctatctt ccttcatttg tcttcaggaa taatgccgcc                          460


<210>  2777
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  2777

Met Trp Ser Ala Ser Gly Phe Gly Gln Leu Arg Gln Pro Met Thr Val 
1               5                   10                  15


Val Ser His Asp Phe Cys Asn Leu Thr Val Ile Leu Leu Leu Phe His 
            20                  25                  30


His Ser Asn Asp Ser Gln Ser Cys Ser Leu Ser Ser Phe Ile Cys Leu 
        35                  40                  45


Gln Glu 
    50


<210>  2778
<211>  4497
<212>  DNA
<213>  Homo sapiens

<400>  2778
gacttacaag ttggctgctg tcgcctgcgc atcggcgggc cgggaggctg agcagtactg     60

ttgagagcgg tgtgaggtgc ttggtagcgc gccgtagctg cttccacgtc cttgcttcac    120

ctcaggtaaa gaaagatgta actgtttgga gaaaaccctc agaagaattt aatggatatc    180

tctacaaagc ccaaggtgtt atagatgacc ttgtctatag tataatagac catatacgcc    240

cagggccttg tcgtttggat tgggacagct tgatgacttc tttggatatt ctggagaact    300

ttgaagagaa ttgctgtgtg atgcgttaca ctactgctgg tcagctttgg aatataattt    360

ccccaagaga atttgttgat ttctcctata ctgtgggcta taaagaaggg cttttatctt    420

gtggaataag tcttgactgg gatgaaaaga gaccagaatt tgttcgagga tataaccatc    480

cctgtggttg gttttgtgtt ccacttaaag acaacccaaa ccagagtctt ttgacaggat    540

atattcagac agatctgcgt gggatgattc ctcagtctgc ggtagataca gccatggcaa    600

gcactttaac caacttctat ggtgatttac gaaaagcttt atgagaggca aaatacattc    660

aaacttgtag tactacagat caactctctc agctacatgg cctgtaaaaa tcattgattc    720

cacttttctg catagccggt agaaaaattt gaaatgtttt tggttcacta gtacaatgtt    780

tggttttatt cctaaagtaa atagctatct aagagagggc attttcactt tttttttttt    840

aaattttgag acaggctctc actctgttgc ccatgctgga gggcagtggt atgatcacag    900

ctcactgcag ctttgatctg accgctcaag gggttattct acctcagcct cctgaatagc    960

tgggaataca ggtgcacgcc actatgcatg gctaattttt gtttaatttt ttgtagagat   1020

gtggtcacac tgtgttgccc aggctggtct tgaactcctg gcctcaagtc attccccacc   1080

ttagcctccc aaagtgttgg gattataagc gtgagccacc atgcctggcc ccaatttaaa   1140

atgtggaatt cagttggtgt ccaagactta tcttgagact cttaaaagca tcagtctgta   1200

actagaacaa atacagtctt agatttaccc aagtgcctag atatcatttt ataatgatta   1260

gaattgagta ttgtgggtcc cctaattctg tgggtgcctt aagtgagaat ttctaaatga   1320

ttttcacatt ctaaatgact ttgggttttg aactctccat ctagtttact tctaaaatgg   1380

gaacttgagg caattcaggt atccaggcaa atctttgtat atattttttt gtgtacatgc   1440

acacatctcg aaatccattt ccgtgtttaa tgttagttgt ttatgtgtta gtattcctgt   1500

gtctactgtt ttgttgttgt taatatgggt aaagtgagcc ctgaaataca tgctaaacaa   1560

gacatgaaat gcagaaaggt acatagtgtt tcaagtgcat ggtagtttga tctgtgtttt   1620

actttattgt gttttcttga gtgtaaagaa agaataaatc aaagttcttc atacccattt   1680

tgacaaagtg gaacagtgga gctgtttttt gcttttgttt ttatttattt tttgccactg   1740

gtgatgatag atttcaaaaa acaaaaggtg gcagcagcac aatgttcatg gtgaattatc   1800

tcatagtatc tagattgatc aagatctgac agaaggaatg cacaaaggat tctatattct   1860

taatgattta ttaattacca ggatcctttt ctaaattgaa tgtacttttg aattactagg   1920

tttcttcttt ttttttgttc tgcaatagtg aaagaaaact cagtagttta gtttcagttt   1980

ctcatggaaa ttggtaaatg ttagttttga cttcatctat tttttatttg tttttattag   2040

cgtagagtag gaagtctcat attctactgt tctatctagg atggtgaaat tccaaaggtg   2100

cctaacttga gtaagggatt tgtgacaaga tagtacacat tactataagg gctattattt   2160

cctgaactgg atgtccctaa aagcaaataa actgcccact atctctactc tagtgctctc   2220

tttgtcctta tcaacatata cctccaataa gtaattacat aattcaccgt taaacatgga   2280

cccactctag gtaaaattac cctcatggaa acattttcac tgtgagaatg atgaatttaa   2340

aaattatgtt tgaatcacct aaaatgtatg tgcagcttct agatggcccc ttagatctgc   2400

tgggctctag ctgtgtactt taaaaaaaca aaaacagctt tattgatata taatttacat   2460

attatgtaat ttacccactt ttaagtatct aattcagtga tgttttaata catatgtaga   2520

actatgcagc catcagcaca atctggattt agaacgtttc catcattcca aaagattcct   2580

tttgtctttt ttgcagactc atacctaaca caaatctaaa gtttatcact gttgccagga   2640

taattacagc aggttatgtt tggtttcatt tttaagagtg gaggtgttca tgattctaag   2700

ctcaggaatc ttgtgatcat gtattaaata tgttatctca tactataatg ataaaaaagc   2760

ttaatgatgt gggttgggat ggatattaac ataaataatt gagtccgctg cttctatagc   2820

aatgctgtag gatagaacaa taatgtaagt gatatatgta attaaaaaat tctagaagcc   2880

acattaaaaa ataaaaataa acagctgaag ttaattttaa tattttattt aactcaatac   2940

atccaaaatg ttatcatttt aacatgtaat tgatgtaaag atttattctg atagtttgta   3000

ctatttcttg tactaatttt ttgaaatctg gtatgcattt tacaaatttg ggcaagccac   3060

attttaagtg ctcattagcc acatgaggcc agtggatact gtattgaata gcacagtcct   3120

atagcatatt tattaatttg tcttgtagta agatgaaata gacaataata cggaataata   3180

tcttaaatgg aaatctttgt tagtctctag agccttcatt gcttgataaa taggacatct   3240

aaactttaga tataaatcag ttgtcaatga gataaaatta ttgccagcaa atattttcct   3300

tcaaagataa gtaacttttg atatggcagt tggtgaaatg aaagaatata atctgccttc   3360

ttgttaaatg gttgactatt ctgtagcttg taggtagtac gtattagaaa cttgtgtatg   3420

tgggaaatat ttggcataat actgttttca gtatatagta gctatttttt aaggaaatta   3480

gtttcataca agaaaaagat tattataaaa gtgatacttt tgcatgaaat attagtttgt   3540

gttgataact cttagttaac ccttaaagtt taaaacagta ctcaaaaaaa aataatgaga   3600

atctagtatt ctgtagttaa ctaatctata agataaattg ctaaagtact agggagcttg   3660

taaatcttaa aaatcttttt atttcagtgt tcattcaggt tggatatatt tgaaattgta   3720

gatttctatc tgtacaacat ctcctagtta atagaatttt tttccttccc ctcccttctc   3780

tctcctcctc cttttctaac caaagggcat tttatcaaca atcatgctga attcaattaa   3840

tatctcaagc taaaaaacta tgtaattgag gttgtatctg gagaagatgg gaaaacattg   3900

tataatttaa gcccttaatt gtctgttgag cttttagggc tgagtaattg cctttcatac   3960

aaataaaagc tttaactctt ttctcaagag tgtaccaccg tccttagaat caggtgtttt   4020

aaatccagtt tcttttaatt aaatgggact gtagtgatcc ctaccctgta gagaaatcaa   4080

cagaactaga gaagctaagg gcttgatcag gtttccccta gaacctgtgt tgcctgcctg   4140

ctgtatcttc catgtctttc ttattcaact tctagaagta gagaaggttg ggacttgagt   4200

gtagaagaaa catcagaata atttcaaaaa acaggaagtt ggaactataa tttttaaatt   4260

attgtattgt ttttacggat tttacatgta tagttaaata ttaaaattca tctcttgcag   4320

ttcaataaaa gctatagtat agattttatt tttaagaagt ttatataatt cttttgtgaa   4380

ccaatatgta aaactagaat atttattaaa ctaataatat gtattagtat caataaaata   4440

tgtatttatt tttaaattgg tatgaaacaa aataaaaatt tgtagacact cttaaaa      4497


<210>  2779
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  2779

Met Thr Ser Leu Asp Ile Leu Glu Asn Phe Glu Glu Asn Cys Cys Val 
1               5                   10                  15


Met Arg Tyr Thr Thr Ala Gly Gln Leu Trp Asn Ile Ile Ser Pro Arg 
            20                  25                  30


Glu Phe Val Asp Phe Ser Tyr Thr Val Gly Tyr Lys Glu Gly Leu Leu 
        35                  40                  45


Ser Cys Gly Ile Ser Leu Asp Trp Asp Glu Lys Arg Pro Glu Phe Val 
    50                  55                  60


Arg Gly Tyr Asn His Pro Cys Gly Trp Phe Cys Val Pro Leu Lys Asp 
65                  70                  75                  80


Asn Pro Asn Gln Ser Leu Leu Thr Gly Tyr Ile Gln Thr Asp Leu Arg 
                85                  90                  95


Gly Met Ile Pro Gln Ser Ala Val Asp Thr Ala Met Ala Ser Thr Leu 
            100                 105                 110


Thr Asn Phe Tyr Gly Asp Leu Arg Lys Ala Leu 
        115                 120


<210>  2780
<211>  4504
<212>  DNA
<213>  Homo sapiens

<400>  2780
agttggctgc gaccagcggt gacttacaag ttggctgctg tcgcctgcgc atcggcgggc     60

cgggaggctg agcagtactg ttgagagcgg tgtgaggtgc ttggtagcgc gccgtagctg    120

cttccacgtc cttgcttcac ctcaggtaaa gagagaagta atggaaggcc tgtctgatgt    180

tgcttctttt gcaactaaac ttaaaaacac tctcatccag taccatagca ttgaagaaga    240

taagtggcga gttgctaaga aaacgaaaga tgtaactgtt tggagaaaac cctcagaaga    300

atttaatgga tatctaattg ctgtgtgatg cgttacacta ctgctggtca gctttggaat    360

ataatttccc caagagaatt tgttgatttc tcctatactg tgggctataa agaagggctt    420

ttatcttgtg gaataagtct tgactgggat gaaaagagac cagaatttgt tcgaggatat    480

aaccatccct gtggttggtt ttgtgttcca cttaaagaca acccaaacca gagtcttttg    540

acaggatata ttcagacaga tctgcgtggg atgattcctc agtctgcggt agatacagcc    600

atggcaagca ctttaaccaa cttctatggt gatttacgaa aagctttatg agaggcaaaa    660

tacattcaaa cttgtagtac tacagatcaa ctctctcagc tacatggcct gtaaaaatca    720

ttgattccac ttttctgcat agccggtaga aaaatttgaa atgtttttgg ttcactagta    780

caatgtttgg ttttattcct aaagtaaata gctatctaag agagggcatt ttcacttttt    840

tttttttaaa ttttgagaca ggctctcact ctgttgccca tgctggaggg cagtggtatg    900

atcacagctc actgcagctt tgatctgacc gctcaagggg ttattctacc tcagcctcct    960

gaatagctgg gaatacaggt gcacgccact atgcatggct aatttttgtt taattttttg   1020

tagagatgtg gtcacactgt gttgcccagg ctggtcttga actcctggcc tcaagtcatt   1080

ccccacctta gcctcccaaa gtgttgggat tataagcgtg agccaccatg cctggcccca   1140

atttaaaatg tggaattcag ttggtgtcca agacttatct tgagactctt aaaagcatca   1200

gtctgtaact agaacaaata cagtcttaga tttacccaag tgcctagata tcattttata   1260

atgattagaa ttgagtattg tgggtcccct aattctgtgg gtgccttaag tgagaatttc   1320

taaatgattt tcacattcta aatgactttg ggttttgaac tctccatcta gtttacttct   1380

aaaatgggaa cttgaggcaa ttcaggtatc caggcaaatc tttgtatata tttttttgtg   1440

tacatgcaca catctcgaaa tccatttccg tgtttaatgt tagttgttta tgtgttagta   1500

ttcctgtgtc tactgttttg ttgttgttaa tatgggtaaa gtgagccctg aaatacatgc   1560

taaacaagac atgaaatgca gaaaggtaca tagtgtttca agtgcatggt agtttgatct   1620

gtgttttact ttattgtgtt ttcttgagtg taaagaaaga ataaatcaaa gttcttcata   1680

cccattttga caaagtggaa cagtggagct gttttttgct tttgttttta tttatttttt   1740

gccactggtg atgatagatt tcaaaaaaca aaaggtggca gcagcacaat gttcatggtg   1800

aattatctca tagtatctag attgatcaag atctgacaga aggaatgcac aaaggattct   1860

atattcttaa tgatttatta attaccagga tccttttcta aattgaatgt acttttgaat   1920

tactaggttt cttctttttt tttgttctgc aatagtgaaa gaaaactcag tagtttagtt   1980

tcagtttctc atggaaattg gtaaatgtta gttttgactt catctatttt ttatttgttt   2040

ttattagcgt agagtaggaa gtctcatatt ctactgttct atctaggatg gtgaaattcc   2100

aaaggtgcct aacttgagta agggatttgt gacaagatag tacacattac tataagggct   2160

attatttcct gaactggatg tccctaaaag caaataaact gcccactatc tctactctag   2220

tgctctcttt gtccttatca acatatacct ccaataagta attacataat tcaccgttaa   2280

acatggaccc actctaggta aaattaccct catggaaaca ttttcactgt gagaatgatg   2340

aatttaaaaa ttatgtttga atcacctaaa atgtatgtgc agcttctaga tggcccctta   2400

gatctgctgg gctctagctg tgtactttaa aaaaacaaaa acagctttat tgatatataa   2460

tttacatatt atgtaattta cccactttta agtatctaat tcagtgatgt tttaatacat   2520

atgtagaact atgcagccat cagcacaatc tggatttaga acgtttccat cattccaaaa   2580

gattcctttt gtcttttttg cagactcata cctaacacaa atctaaagtt tatcactgtt   2640

gccaggataa ttacagcagg ttatgtttgg tttcattttt aagagtggag gtgttcatga   2700

ttctaagctc aggaatcttg tgatcatgta ttaaatatgt tatctcatac tataatgata   2760

aaaaagctta atgatgtggg ttgggatgga tattaacata aataattgag tccgctgctt   2820

ctatagcaat gctgtaggat agaacaataa tgtaagtgat atatgtaatt aaaaaattct   2880

agaagccaca ttaaaaaata aaaataaaca gctgaagtta attttaatat tttatttaac   2940

tcaatacatc caaaatgtta tcattttaac atgtaattga tgtaaagatt tattctgata   3000

gtttgtacta tttcttgtac taattttttg aaatctggta tgcattttac aaatttgggc   3060

aagccacatt ttaagtgctc attagccaca tgaggccagt ggatactgta ttgaatagca   3120

cagtcctata gcatatttat taatttgtct tgtagtaaga tgaaatagac aataatacgg   3180

aataatatct taaatggaaa tctttgttag tctctagagc cttcattgct tgataaatag   3240

gacatctaaa ctttagatat aaatcagttg tcaatgagat aaaattattg ccagcaaata   3300

ttttccttca aagataagta acttttgata tggcagttgg tgaaatgaaa gaatataatc   3360

tgccttcttg ttaaatggtt gactattctg tagcttgtag gtagtacgta ttagaaactt   3420

gtgtatgtgg gaaatatttg gcataatact gttttcagta tatagtagct attttttaag   3480

gaaattagtt tcatacaaga aaaagattat tataaaagtg atacttttgc atgaaatatt   3540

agtttgtgtt gataactctt agttaaccct taaagtttaa aacagtactc aaaaaaaaat   3600

aatgagaatc tagtattctg tagttaacta atctataaga taaattgcta aagtactagg   3660

gagcttgtaa atcttaaaaa tctttttatt tcagtgttca ttcaggttgg atatatttga   3720

aattgtagat ttctatctgt acaacatctc ctagttaata gaattttttt ccttcccctc   3780

ccttctctct cctcctcctt ttctaaccaa agggcatttt atcaacaatc atgctgaatt   3840

caattaatat ctcaagctaa aaaactatgt aattgaggtt gtatctggag aagatgggaa   3900

aacattgtat aatttaagcc cttaattgtc tgttgagctt ttagggctga gtaattgcct   3960

ttcatacaaa taaaagcttt aactcttttc tcaagagtgt accaccgtcc ttagaatcag   4020

gtgttttaaa tccagtttct tttaattaaa tgggactgta gtgatcccta ccctgtagag   4080

aaatcaacag aactagagaa gctaagggct tgatcaggtt tcccctagaa cctgtgttgc   4140

ctgcctgctg tatcttccat gtctttctta ttcaacttct agaagtagag aaggttggga   4200

cttgagtgta gaagaaacat cagaataatt tcaaaaaaca ggaagttgga actataattt   4260

ttaaattatt gtattgtttt tacggatttt acatgtatag ttaaatatta aaattcatct   4320

cttgcagttc aataaaagct atagtataga ttttattttt aagaagttta tataattctt   4380

ttgtgaacca atatgtaaaa ctagaatatt tattaaacta ataatatgta ttagtatcaa   4440

taaaatatgt atttattttt aaattggtat gaaacaaaat aaaaatttgt agacactctt   4500

aaaa                                                                4504


<210>  2781
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  2781

Met Arg Tyr Thr Thr Ala Gly Gln Leu Trp Asn Ile Ile Ser Pro Arg 
1               5                   10                  15


Glu Phe Val Asp Phe Ser Tyr Thr Val Gly Tyr Lys Glu Gly Leu Leu 
            20                  25                  30


Ser Cys Gly Ile Ser Leu Asp Trp Asp Glu Lys Arg Pro Glu Phe Val 
        35                  40                  45


Arg Gly Tyr Asn His Pro Cys Gly Trp Phe Cys Val Pro Leu Lys Asp 
    50                  55                  60


Asn Pro Asn Gln Ser Leu Leu Thr Gly Tyr Ile Gln Thr Asp Leu Arg 
65                  70                  75                  80


Gly Met Ile Pro Gln Ser Ala Val Asp Thr Ala Met Ala Ser Thr Leu 
                85                  90                  95


Thr Asn Phe Tyr Gly Asp Leu Arg Lys Ala Leu 
            100                 105


<210>  2782
<211>  4420
<212>  DNA
<213>  Homo sapiens

<400>  2782
agttggctgc gaccagcggt gacttacaag ttggctgctg tcgcctgcgc atcggcgggc     60

cgggaggctg agcagtactg ttgagagcgg tgtgaggtgc ttggtagcgc gccgtagctg    120

cttccacgtc cttgcttcac ctcaggtaaa gagagaagta atggaaggcc tgtctgatgt    180

tgcttctttt gcaactaaac ttaaaaacac tctcatccag taccatagca ttgaagaaga    240

taagtggcga gttgctaaga aaacgaaaga tgtaactgtt tggagaaaac cctcagaaga    300

atttaatgga tatctaattg ctgtgtgatg cgttacacta ctgctggaat aagtcttgac    360

tgggatgaaa agagaccaga atttgttcga ggatataacc atccctgtgg ttggttttgt    420

gttccactta aagacaaccc aaaccagagt cttttgacag gatatattca gacagatctg    480

cgtgggatga ttcctcagtc tgcggtagat acagccatgg caagcacttt aaccaacttc    540

tatggtgatt tacgaaaagc tttatgagag gcaaaataca ttcaaacttg tagtactaca    600

gatcaactct ctcagctaca tggcctgtaa aaatcattga ttccactttt ctgcatagcc    660

ggtagaaaaa tttgaaatgt ttttggttca ctagtacaat gtttggtttt attcctaaag    720

taaatagcta tctaagagag ggcattttca cttttttttt tttaaatttt gagacaggct    780

ctcactctgt tgcccatgct ggagggcagt ggtatgatca cagctcactg cagctttgat    840

ctgaccgctc aaggggttat tctacctcag cctcctgaat agctgggaat acaggtgcac    900

gccactatgc atggctaatt tttgtttaat tttttgtaga gatgtggtca cactgtgttg    960

cccaggctgg tcttgaactc ctggcctcaa gtcattcccc accttagcct cccaaagtgt   1020

tgggattata agcgtgagcc accatgcctg gccccaattt aaaatgtgga attcagttgg   1080

tgtccaagac ttatcttgag actcttaaaa gcatcagtct gtaactagaa caaatacagt   1140

cttagattta cccaagtgcc tagatatcat tttataatga ttagaattga gtattgtggg   1200

tcccctaatt ctgtgggtgc cttaagtgag aatttctaaa tgattttcac attctaaatg   1260

actttgggtt ttgaactctc catctagttt acttctaaaa tgggaacttg aggcaattca   1320

ggtatccagg caaatctttg tatatatttt tttgtgtaca tgcacacatc tcgaaatcca   1380

tttccgtgtt taatgttagt tgtttatgtg ttagtattcc tgtgtctact gttttgttgt   1440

tgttaatatg ggtaaagtga gccctgaaat acatgctaaa caagacatga aatgcagaaa   1500

ggtacatagt gtttcaagtg catggtagtt tgatctgtgt tttactttat tgtgttttct   1560

tgagtgtaaa gaaagaataa atcaaagttc ttcataccca ttttgacaaa gtggaacagt   1620

ggagctgttt tttgcttttg tttttattta ttttttgcca ctggtgatga tagatttcaa   1680

aaaacaaaag gtggcagcag cacaatgttc atggtgaatt atctcatagt atctagattg   1740

atcaagatct gacagaagga atgcacaaag gattctatat tcttaatgat ttattaatta   1800

ccaggatcct tttctaaatt gaatgtactt ttgaattact aggtttcttc tttttttttg   1860

ttctgcaata gtgaaagaaa actcagtagt ttagtttcag tttctcatgg aaattggtaa   1920

atgttagttt tgacttcatc tattttttat ttgtttttat tagcgtagag taggaagtct   1980

catattctac tgttctatct aggatggtga aattccaaag gtgcctaact tgagtaaggg   2040

atttgtgaca agatagtaca cattactata agggctatta tttcctgaac tggatgtccc   2100

taaaagcaaa taaactgccc actatctcta ctctagtgct ctctttgtcc ttatcaacat   2160

atacctccaa taagtaatta cataattcac cgttaaacat ggacccactc taggtaaaat   2220

taccctcatg gaaacatttt cactgtgaga atgatgaatt taaaaattat gtttgaatca   2280

cctaaaatgt atgtgcagct tctagatggc cccttagatc tgctgggctc tagctgtgta   2340

ctttaaaaaa acaaaaacag ctttattgat atataattta catattatgt aatttaccca   2400

cttttaagta tctaattcag tgatgtttta atacatatgt agaactatgc agccatcagc   2460

acaatctgga tttagaacgt ttccatcatt ccaaaagatt ccttttgtct tttttgcaga   2520

ctcataccta acacaaatct aaagtttatc actgttgcca ggataattac agcaggttat   2580

gtttggtttc atttttaaga gtggaggtgt tcatgattct aagctcagga atcttgtgat   2640

catgtattaa atatgttatc tcatactata atgataaaaa agcttaatga tgtgggttgg   2700

gatggatatt aacataaata attgagtccg ctgcttctat agcaatgctg taggatagaa   2760

caataatgta agtgatatat gtaattaaaa aattctagaa gccacattaa aaaataaaaa   2820

taaacagctg aagttaattt taatatttta tttaactcaa tacatccaaa atgttatcat   2880

tttaacatgt aattgatgta aagatttatt ctgatagttt gtactatttc ttgtactaat   2940

tttttgaaat ctggtatgca ttttacaaat ttgggcaagc cacattttaa gtgctcatta   3000

gccacatgag gccagtggat actgtattga atagcacagt cctatagcat atttattaat   3060

ttgtcttgta gtaagatgaa atagacaata atacggaata atatcttaaa tggaaatctt   3120

tgttagtctc tagagccttc attgcttgat aaataggaca tctaaacttt agatataaat   3180

cagttgtcaa tgagataaaa ttattgccag caaatatttt ccttcaaaga taagtaactt   3240

ttgatatggc agttggtgaa atgaaagaat ataatctgcc ttcttgttaa atggttgact   3300

attctgtagc ttgtaggtag tacgtattag aaacttgtgt atgtgggaaa tatttggcat   3360

aatactgttt tcagtatata gtagctattt tttaaggaaa ttagtttcat acaagaaaaa   3420

gattattata aaagtgatac ttttgcatga aatattagtt tgtgttgata actcttagtt   3480

aacccttaaa gtttaaaaca gtactcaaaa aaaaataatg agaatctagt attctgtagt   3540

taactaatct ataagataaa ttgctaaagt actagggagc ttgtaaatct taaaaatctt   3600

tttatttcag tgttcattca ggttggatat atttgaaatt gtagatttct atctgtacaa   3660

catctcctag ttaatagaat ttttttcctt cccctccctt ctctctcctc ctccttttct   3720

aaccaaaggg cattttatca acaatcatgc tgaattcaat taatatctca agctaaaaaa   3780

ctatgtaatt gaggttgtat ctggagaaga tgggaaaaca ttgtataatt taagccctta   3840

attgtctgtt gagcttttag ggctgagtaa ttgcctttca tacaaataaa agctttaact   3900

cttttctcaa gagtgtacca ccgtccttag aatcaggtgt tttaaatcca gtttctttta   3960

attaaatggg actgtagtga tccctaccct gtagagaaat caacagaact agagaagcta   4020

agggcttgat caggtttccc ctagaacctg tgttgcctgc ctgctgtatc ttccatgtct   4080

ttcttattca acttctagaa gtagagaagg ttgggacttg agtgtagaag aaacatcaga   4140

ataatttcaa aaaacaggaa gttggaacta taatttttaa attattgtat tgtttttacg   4200

gattttacat gtatagttaa atattaaaat tcatctcttg cagttcaata aaagctatag   4260

tatagatttt atttttaaga agtttatata attcttttgt gaaccaatat gtaaaactag   4320

aatatttatt aaactaataa tatgtattag tatcaataaa atatgtattt atttttaaat   4380

tggtatgaaa caaaataaaa atttgtagac actcttaaaa                         4420


<210>  2783
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  2783

Met Arg Tyr Thr Thr Ala Gly Ile Ser Leu Asp Trp Asp Glu Lys Arg 
1               5                   10                  15


Pro Glu Phe Val Arg Gly Tyr Asn His Pro Cys Gly Trp Phe Cys Val 
            20                  25                  30


Pro Leu Lys Asp Asn Pro Asn Gln Ser Leu Leu Thr Gly Tyr Ile Gln 
        35                  40                  45


Thr Asp Leu Arg Gly Met Ile Pro Gln Ser Ala Val Asp Thr Ala Met 
    50                  55                  60


Ala Ser Thr Leu Thr Asn Phe Tyr Gly Asp Leu Arg Lys Ala Leu 
65                  70                  75


<210>  2784
<211>  4390
<212>  DNA
<213>  Homo sapiens

<400>  2784
agttggctgc gaccagcggt gacttacaag ttggctgctg tcgcctgcgc atcggcgggc     60

cgggaggctg agcagtactg ttgagagcgg tgtgaggtgc ttggtagcgc gccgtagctg    120

cttccacgtc cttgcttcac ctcaggtaaa gaaagatgta actgtttgga gaaaaccctc    180

agaagaattt aatggatatc taattgctgt gtgatgcgtt acactactgc tggtcagctt    240

tggaatataa tttccccaag agaatttgtt gatttctcct atactgtggg ctataaagaa    300

gggcttttat cttgtggaat aagtcttgac tgggatgaaa agagaccaga atttgttcga    360

ggatataacc atccctgtgg ttggttttgt gttccactta aagacaaccc aaaccagagt    420

cttttgacag gatatattca gacagatctg cgtgggatga ttcctcagtc tgcggtagat    480

acagccatgg caagcacttt aaccaacttc tatggtgatt tacgaaaagc tttatgagag    540

gcaaaataca ttcaaacttg tagtactaca gatcaactct ctcagctaca tggcctgtaa    600

aaatcattga ttccactttt ctgcatagcc ggtagaaaaa tttgaaatgt ttttggttca    660

ctagtacaat gtttggtttt attcctaaag taaatagcta tctaagagag ggcattttca    720

cttttttttt tttaaatttt gagacaggct ctcactctgt tgcccatgct ggagggcagt    780

ggtatgatca cagctcactg cagctttgat ctgaccgctc aaggggttat tctacctcag    840

cctcctgaat agctgggaat acaggtgcac gccactatgc atggctaatt tttgtttaat    900

tttttgtaga gatgtggtca cactgtgttg cccaggctgg tcttgaactc ctggcctcaa    960

gtcattcccc accttagcct cccaaagtgt tgggattata agcgtgagcc accatgcctg   1020

gccccaattt aaaatgtgga attcagttgg tgtccaagac ttatcttgag actcttaaaa   1080

gcatcagtct gtaactagaa caaatacagt cttagattta cccaagtgcc tagatatcat   1140

tttataatga ttagaattga gtattgtggg tcccctaatt ctgtgggtgc cttaagtgag   1200

aatttctaaa tgattttcac attctaaatg actttgggtt ttgaactctc catctagttt   1260

acttctaaaa tgggaacttg aggcaattca ggtatccagg caaatctttg tatatatttt   1320

tttgtgtaca tgcacacatc tcgaaatcca tttccgtgtt taatgttagt tgtttatgtg   1380

ttagtattcc tgtgtctact gttttgttgt tgttaatatg ggtaaagtga gccctgaaat   1440

acatgctaaa caagacatga aatgcagaaa ggtacatagt gtttcaagtg catggtagtt   1500

tgatctgtgt tttactttat tgtgttttct tgagtgtaaa gaaagaataa atcaaagttc   1560

ttcataccca ttttgacaaa gtggaacagt ggagctgttt tttgcttttg tttttattta   1620

ttttttgcca ctggtgatga tagatttcaa aaaacaaaag gtggcagcag cacaatgttc   1680

atggtgaatt atctcatagt atctagattg atcaagatct gacagaagga atgcacaaag   1740

gattctatat tcttaatgat ttattaatta ccaggatcct tttctaaatt gaatgtactt   1800

ttgaattact aggtttcttc tttttttttg ttctgcaata gtgaaagaaa actcagtagt   1860

ttagtttcag tttctcatgg aaattggtaa atgttagttt tgacttcatc tattttttat   1920

ttgtttttat tagcgtagag taggaagtct catattctac tgttctatct aggatggtga   1980

aattccaaag gtgcctaact tgagtaaggg atttgtgaca agatagtaca cattactata   2040

agggctatta tttcctgaac tggatgtccc taaaagcaaa taaactgccc actatctcta   2100

ctctagtgct ctctttgtcc ttatcaacat atacctccaa taagtaatta cataattcac   2160

cgttaaacat ggacccactc taggtaaaat taccctcatg gaaacatttt cactgtgaga   2220

atgatgaatt taaaaattat gtttgaatca cctaaaatgt atgtgcagct tctagatggc   2280

cccttagatc tgctgggctc tagctgtgta ctttaaaaaa acaaaaacag ctttattgat   2340

atataattta catattatgt aatttaccca cttttaagta tctaattcag tgatgtttta   2400

atacatatgt agaactatgc agccatcagc acaatctgga tttagaacgt ttccatcatt   2460

ccaaaagatt ccttttgtct tttttgcaga ctcataccta acacaaatct aaagtttatc   2520

actgttgcca ggataattac agcaggttat gtttggtttc atttttaaga gtggaggtgt   2580

tcatgattct aagctcagga atcttgtgat catgtattaa atatgttatc tcatactata   2640

atgataaaaa agcttaatga tgtgggttgg gatggatatt aacataaata attgagtccg   2700

ctgcttctat agcaatgctg taggatagaa caataatgta agtgatatat gtaattaaaa   2760

aattctagaa gccacattaa aaaataaaaa taaacagctg aagttaattt taatatttta   2820

tttaactcaa tacatccaaa atgttatcat tttaacatgt aattgatgta aagatttatt   2880

ctgatagttt gtactatttc ttgtactaat tttttgaaat ctggtatgca ttttacaaat   2940

ttgggcaagc cacattttaa gtgctcatta gccacatgag gccagtggat actgtattga   3000

atagcacagt cctatagcat atttattaat ttgtcttgta gtaagatgaa atagacaata   3060

atacggaata atatcttaaa tggaaatctt tgttagtctc tagagccttc attgcttgat   3120

aaataggaca tctaaacttt agatataaat cagttgtcaa tgagataaaa ttattgccag   3180

caaatatttt ccttcaaaga taagtaactt ttgatatggc agttggtgaa atgaaagaat   3240

ataatctgcc ttcttgttaa atggttgact attctgtagc ttgtaggtag tacgtattag   3300

aaacttgtgt atgtgggaaa tatttggcat aatactgttt tcagtatata gtagctattt   3360

tttaaggaaa ttagtttcat acaagaaaaa gattattata aaagtgatac ttttgcatga   3420

aatattagtt tgtgttgata actcttagtt aacccttaaa gtttaaaaca gtactcaaaa   3480

aaaaataatg agaatctagt attctgtagt taactaatct ataagataaa ttgctaaagt   3540

actagggagc ttgtaaatct taaaaatctt tttatttcag tgttcattca ggttggatat   3600

atttgaaatt gtagatttct atctgtacaa catctcctag ttaatagaat ttttttcctt   3660

cccctccctt ctctctcctc ctccttttct aaccaaaggg cattttatca acaatcatgc   3720

tgaattcaat taatatctca agctaaaaaa ctatgtaatt gaggttgtat ctggagaaga   3780

tgggaaaaca ttgtataatt taagccctta attgtctgtt gagcttttag ggctgagtaa   3840

ttgcctttca tacaaataaa agctttaact cttttctcaa gagtgtacca ccgtccttag   3900

aatcaggtgt tttaaatcca gtttctttta attaaatggg actgtagtga tccctaccct   3960

gtagagaaat caacagaact agagaagcta agggcttgat caggtttccc ctagaacctg   4020

tgttgcctgc ctgctgtatc ttccatgtct ttcttattca acttctagaa gtagagaagg   4080

ttgggacttg agtgtagaag aaacatcaga ataatttcaa aaaacaggaa gttggaacta   4140

taatttttaa attattgtat tgtttttacg gattttacat gtatagttaa atattaaaat   4200

tcatctcttg cagttcaata aaagctatag tatagatttt atttttaaga agtttatata   4260

attcttttgt gaaccaatat gtaaaactag aatatttatt aaactaataa tatgtattag   4320

tatcaataaa atatgtattt atttttaaat tggtatgaaa caaaataaaa atttgtagac   4380

actcttaaaa                                                          4390


<210>  2785
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  2785

Met Arg Tyr Thr Thr Ala Gly Gln Leu Trp Asn Ile Ile Ser Pro Arg 
1               5                   10                  15


Glu Phe Val Asp Phe Ser Tyr Thr Val Gly Tyr Lys Glu Gly Leu Leu 
            20                  25                  30


Ser Cys Gly Ile Ser Leu Asp Trp Asp Glu Lys Arg Pro Glu Phe Val 
        35                  40                  45


Arg Gly Tyr Asn His Pro Cys Gly Trp Phe Cys Val Pro Leu Lys Asp 
    50                  55                  60


Asn Pro Asn Gln Ser Leu Leu Thr Gly Tyr Ile Gln Thr Asp Leu Arg 
65                  70                  75                  80


Gly Met Ile Pro Gln Ser Ala Val Asp Thr Ala Met Ala Ser Thr Leu 
                85                  90                  95


Thr Asn Phe Tyr Gly Asp Leu Arg Lys Ala Leu 
            100                 105


<210>  2786
<211>  4658
<212>  DNA
<213>  Homo sapiens

<400>  2786
cttgccctga ggcgctgggt gccttccagt tggctgcgac cagcggtgac ttacaagttg     60

gctgctgtcg cctgcgcatc ggcgggccgg gaggctgagc agtactgttg agagcggtgt    120

gaggtgcttg gtagcgcgcc gtagctgctt ccacgtcctt gcttcacctc aggtaaagag    180

agaagtaatg gaaggcctgt ctgatgttgc ttcttttgca actaaactta aaaacactct    240

catccagtac catagcattg aagaagataa gtggcgagtt gctaagaaaa cgaaagatgt    300

aactgtttgg agaaaaccct cagaagaatt taatggatat ctctacaaag cccaaggtgt    360

tatagatgac cttgtctata gtataataga ccatatacgc ccagggcctt gtcgtttgga    420

ttgggacagc ttgatgactt ctttggatat tctggagaac tttgaagaga attgctgtgt    480

gatgcgttac actactgctg gtcagctttg gaatataatt tccccaagag aatttgttga    540

tttctcctat actgtgggct ataaagaagg gcttttatct tgtggaataa gtcttgactg    600

ggatgaaaag agaccagaat ttgttcgagg atataaccat ccctgtggtt ggttttgtgt    660

tccacttaaa gacaacccaa accagagtct tttgacagga tatattcaga cagatctgcg    720

tgggatgatt cctcagtctg cggtagatac agccatggca agcactttaa ccaacttcta    780

tggtgattta cgaaaagctt tatgagaggc aaaatacatt caaacttgta gtactacaga    840

tcaactctct cagctacatg gcctgtaaaa atcattgatt ccacttttct gcatagccgg    900

tagaaaaatt tgaaatgttt ttggttcact agtacaatgt ttggttttat tcctaaagta    960

aatagctatc taagagaggg cattttcact tttttttttt taaattttga gacaggctct   1020

cactctgttg cccatgctgg agggcagtgg tatgatcaca gctcactgca gctttgatct   1080

gaccgctcaa ggggttattc tacctcagcc tcctgaatag ctgggaatac aggtgcacgc   1140

cactatgcat ggctaatttt tgtttaattt tttgtagaga tgtggtcaca ctgtgttgcc   1200

caggctggtc ttgaactcct ggcctcaagt cattccccac cttagcctcc caaagtgttg   1260

ggattataag cgtgagccac catgcctggc cccaatttaa aatgtggaat tcagttggtg   1320

tccaagactt atcttgagac tcttaaaagc atcagtctgt aactagaaca aatacagtct   1380

tagatttacc caagtgccta gatatcattt tataatgatt agaattgagt attgtgggtc   1440

ccctaattct gtgggtgcct taagtgagaa tttctaaatg attttcacat tctaaatgac   1500

tttgggtttt gaactctcca tctagtttac ttctaaaatg ggaacttgag gcaattcagg   1560

tatccaggca aatctttgta tatatttttt tgtgtacatg cacacatctc gaaatccatt   1620

tccgtgttta atgttagttg tttatgtgtt agtattcctg tgtctactgt tttgttgttg   1680

ttaatatggg taaagtgagc cctgaaatac atgctaaaca agacatgaaa tgcagaaagg   1740

tacatagtgt ttcaagtgca tggtagtttg atctgtgttt tactttattg tgttttcttg   1800

agtgtaaaga aagaataaat caaagttctt catacccatt ttgacaaagt ggaacagtgg   1860

agctgttttt tgcttttgtt tttatttatt ttttgccact ggtgatgata gatttcaaaa   1920

aacaaaaggt ggcagcagca caatgttcat ggtgaattat ctcatagtat ctagattgat   1980

caagatctga cagaaggaat gcacaaagga ttctatattc ttaatgattt attaattacc   2040

aggatccttt tctaaattga atgtactttt gaattactag gtttcttctt tttttttgtt   2100

ctgcaatagt gaaagaaaac tcagtagttt agtttcagtt tctcatggaa attggtaaat   2160

gttagttttg acttcatcta ttttttattt gtttttatta gcgtagagta ggaagtctca   2220

tattctactg ttctatctag gatggtgaaa ttccaaaggt gcctaacttg agtaagggat   2280

ttgtgacaag atagtacaca ttactataag ggctattatt tcctgaactg gatgtcccta   2340

aaagcaaata aactgcccac tatctctact ctagtgctct ctttgtcctt atcaacatat   2400

acctccaata agtaattaca taattcaccg ttaaacatgg acccactcta ggtaaaatta   2460

ccctcatgga aacattttca ctgtgagaat gatgaattta aaaattatgt ttgaatcacc   2520

taaaatgtat gtgcagcttc tagatggccc cttagatctg ctgggctcta gctgtgtact   2580

ttaaaaaaac aaaaacagct ttattgatat ataatttaca tattatgtaa tttacccact   2640

tttaagtatc taattcagtg atgttttaat acatatgtag aactatgcag ccatcagcac   2700

aatctggatt tagaacgttt ccatcattcc aaaagattcc ttttgtcttt tttgcagact   2760

catacctaac acaaatctaa agtttatcac tgttgccagg ataattacag caggttatgt   2820

ttggtttcat ttttaagagt ggaggtgttc atgattctaa gctcaggaat cttgtgatca   2880

tgtattaaat atgttatctc atactataat gataaaaaag cttaatgatg tgggttggga   2940

tggatattaa cataaataat tgagtccgct gcttctatag caatgctgta ggatagaaca   3000

ataatgtaag tgatatatgt aattaaaaaa ttctagaagc cacattaaaa aataaaaata   3060

aacagctgaa gttaatttta atattttatt taactcaata catccaaaat gttatcattt   3120

taacatgtaa ttgatgtaaa gatttattct gatagtttgt actatttctt gtactaattt   3180

tttgaaatct ggtatgcatt ttacaaattt gggcaagcca cattttaagt gctcattagc   3240

cacatgaggc cagtggatac tgtattgaat agcacagtcc tatagcatat ttattaattt   3300

gtcttgtagt aagatgaaat agacaataat acggaataat atcttaaatg gaaatctttg   3360

ttagtctcta gagccttcat tgcttgataa ataggacatc taaactttag atataaatca   3420

gttgtcaatg agataaaatt attgccagca aatattttcc ttcaaagata agtaactttt   3480

gatatggcag ttggtgaaat gaaagaatat aatctgcctt cttgttaaat ggttgactat   3540

tctgtagctt gtaggtagta cgtattagaa acttgtgtat gtgggaaata tttggcataa   3600

tactgttttc agtatatagt agctattttt taaggaaatt agtttcatac aagaaaaaga   3660

ttattataaa agtgatactt ttgcatgaaa tattagtttg tgttgataac tcttagttaa   3720

cccttaaagt ttaaaacagt actcaaaaaa aaataatgag aatctagtat tctgtagtta   3780

actaatctat aagataaatt gctaaagtac tagggagctt gtaaatctta aaaatctttt   3840

tatttcagtg ttcattcagg ttggatatat ttgaaattgt agatttctat ctgtacaaca   3900

tctcctagtt aatagaattt ttttccttcc cctcccttct ctctcctcct ccttttctaa   3960

ccaaagggca ttttatcaac aatcatgctg aattcaatta atatctcaag ctaaaaaact   4020

atgtaattga ggttgtatct ggagaagatg ggaaaacatt gtataattta agcccttaat   4080

tgtctgttga gcttttaggg ctgagtaatt gcctttcata caaataaaag ctttaactct   4140

tttctcaaga gtgtaccacc gtccttagaa tcaggtgttt taaatccagt ttcttttaat   4200

taaatgggac tgtagtgatc cctaccctgt agagaaatca acagaactag agaagctaag   4260

ggcttgatca ggtttcccct agaacctgtg ttgcctgcct gctgtatctt ccatgtcttt   4320

cttattcaac ttctagaagt agagaaggtt gggacttgag tgtagaagaa acatcagaat   4380

aatttcaaaa aacaggaagt tggaactata atttttaaat tattgtattg tttttacgga   4440

ttttacatgt atagttaaat attaaaattc atctcttgca gttcaataaa agctatagta   4500

tagattttat ttttaagaag tttatataat tcttttgtga accaatatgt aaaactagaa   4560

tatttattaa actaataata tgtattagta tcaataaaat atgtatttat ttttaaattg   4620

gtatgaaaca aaataaaaat ttgtagacac tcttaaaa                           4658


<210>  2787
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  2787

Met Glu Gly Leu Ser Asp Val Ala Ser Phe Ala Thr Lys Leu Lys Asn 
1               5                   10                  15


Thr Leu Ile Gln Tyr His Ser Ile Glu Glu Asp Lys Trp Arg Val Ala 
            20                  25                  30


Lys Lys Thr Lys Asp Val Thr Val Trp Arg Lys Pro Ser Glu Glu Phe 
        35                  40                  45


Asn Gly Tyr Leu Tyr Lys Ala Gln Gly Val Ile Asp Asp Leu Val Tyr 
    50                  55                  60


Ser Ile Ile Asp His Ile Arg Pro Gly Pro Cys Arg Leu Asp Trp Asp 
65                  70                  75                  80


Ser Leu Met Thr Ser Leu Asp Ile Leu Glu Asn Phe Glu Glu Asn Cys 
                85                  90                  95


Cys Val Met Arg Tyr Thr Thr Ala Gly Gln Leu Trp Asn Ile Ile Ser 
            100                 105                 110


Pro Arg Glu Phe Val Asp Phe Ser Tyr Thr Val Gly Tyr Lys Glu Gly 
        115                 120                 125


Leu Leu Ser Cys Gly Ile Ser Leu Asp Trp Asp Glu Lys Arg Pro Glu 
    130                 135                 140


Phe Val Arg Gly Tyr Asn His Pro Cys Gly Trp Phe Cys Val Pro Leu 
145                 150                 155                 160


Lys Asp Asn Pro Asn Gln Ser Leu Leu Thr Gly Tyr Ile Gln Thr Asp 
                165                 170                 175


Leu Arg Gly Met Ile Pro Gln Ser Ala Val Asp Thr Ala Met Ala Ser 
            180                 185                 190


Thr Leu Thr Asn Phe Tyr Gly Asp Leu Arg Lys Ala Leu 
        195                 200                 205


<210>  2788
<211>  1470
<212>  DNA
<213>  Homo sapiens

<400>  2788
gccagggggc ggggctgggg gctcggcccg ccttgccctg aggcgctggg tgccttccag     60

ttggctgcga ccagcggtga cttacaagtt ggctgctgtc gcctgcgcat cggcgggccg    120

ggaggctgag cagtactgtt gagagcggtg tgaggtgctt ggtagcgcgc cgtagctgct    180

tccacgtcct tgcttcacct caggtaaaga gagaagtaat ggaaggcctg tctgatgttg    240

cttcttttgc aactaaactt aaaaacactc tcatccagta ccatagcatt gaagaagata    300

agtggcgagt tgctaagaaa acgaaagatg taactgtttg gagaaaaccc tcagaagaat    360

ttaatggata tctctacaaa gcccaaggtg ttatagatga ccttgtctat agtataatag    420

accatatacg cccagggcct tgtcgtttgg attgggacag cttgatgact tctttggata    480

ttctggagaa ctttgaagag aattgctgtg tgatgcgtta cactactgct ggtcagcttt    540

ggaatataat ttccccaaga gaatttgttg atttctccta tactgtgggc tataaagaag    600

ggcttttatc ttgtggtaat aatctcaaca tgttatgctt tttttcagta tggtttaaat    660

atttgtgttt tcttggctgg atgtctcttt ccttgtgaga tatattttca actctgactc    720

tgtaatcact aacatttttt gcaagtgcta aactctaggg agtaaaatag caatatcaaa    780

agagttttga aacccttctg ataagttttt gttcccagtt acacagtatc ctctaggtca    840

gaggtagcaa atgtggatca catgactgcc tctaagaaag ggttctagta aatggatttt    900

cttctaagcc actctcagaa aacagtttct tggtcataca cagagaagta ctagatttgg    960

tgtgtcttag aatattcttc cttccttgag ctgtgttgta tttttctttt caagattaaa   1020

aatactgcca ttggaaggct cctgttttct aaaacgtacc tataggtaaa ttaatattat   1080

tttgtatata gtgtatactt aagttagcag ttgtaagtaa acatctactt gtttattctt   1140

aactagccag taccaaacta taatatggta gtcgctgtgg ggaatagtta cggtaccatg   1200

gatttgattt ttggcacctc aaggcctgga tactacaacc aagatttgta gcttccaagg   1260

agtactaaga tgatatgatg tcatgtattc tgaaaggatt aaaagtttcc ccattaccta   1320

tctgccaacc tcttgtcaga attctccttg gtaagtctct ttttcactct gccatggtca   1380

ctttgggatt taattttcat ctatatggat aataataaat atttaaataa gaattctggt   1440

aatattttaa aatgagagtt ttatgtcagt                                    1470


<210>  2789
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  2789

Met Glu Gly Leu Ser Asp Val Ala Ser Phe Ala Thr Lys Leu Lys Asn 
1               5                   10                  15


Thr Leu Ile Gln Tyr His Ser Ile Glu Glu Asp Lys Trp Arg Val Ala 
            20                  25                  30


Lys Lys Thr Lys Asp Val Thr Val Trp Arg Lys Pro Ser Glu Glu Phe 
        35                  40                  45


Asn Gly Tyr Leu Tyr Lys Ala Gln Gly Val Ile Asp Asp Leu Val Tyr 
    50                  55                  60


Ser Ile Ile Asp His Ile Arg Pro Gly Pro Cys Arg Leu Asp Trp Asp 
65                  70                  75                  80


Ser Leu Met Thr Ser Leu Asp Ile Leu Glu Asn Phe Glu Glu Asn Cys 
                85                  90                  95


Cys Val Met Arg Tyr Thr Thr Ala Gly Gln Leu Trp Asn Ile Ile Ser 
            100                 105                 110


Pro Arg Glu Phe Val Asp Phe Ser Tyr Thr Val Gly Tyr Lys Glu Gly 
        115                 120                 125


Leu Leu Ser Cys Gly Asn Asn Leu Asn Met Leu Cys Phe Phe Ser Val 
    130                 135                 140


Trp Phe Lys Tyr Leu Cys Phe Leu Gly Trp Met Ser Leu Ser Leu 
145                 150                 155


<210>  2790
<211>  849
<212>  DNA
<213>  Homo sapiens

<400>  2790
agttggctgc gaccagcggt gacttacaag ttggctgctg tcgcctgcgc atcggcgggc     60

cgggaggctg agcagtactg ttgagagcgg tgtgaggtgc ttggtagcgc gccgtagctg    120

cttccacgtc cttgcttcac ctcaggtaaa gagagaagta atggaaggcc tgtctgatgt    180

tgcttctttt gcaactaaac ttaaaaacac tctcatccag taccatagca ttgaagaaga    240

taagtggcga gttgctaaga aaacgaaaga tgtaactgtt tggagaaaac cctcagaaga    300

atttaatgga tatctaattg ctgtgtgatg cgttacacta ctgctggtca gctttggaat    360

ataatttccc caagagaatt tgttgatttc tcctatactg tgggctataa agaagggctt    420

ttatcttgtg gtaataatct caacatgtta tgcttttttt cagtatggtt taaatatttg    480

tgttttcttg gctggatgtc tctttccttg tgagatatat tttcaactct gactctgtaa    540

tcactaacat tttttgcaag tgctaaactc tagggagtaa aatagcaata tcaaaagagt    600

tttgaaaccc ttctgataag tttttgttcc cagttacaca gtatcctcta ggtcagaggt    660

agcaaatgtg gatcacatga ctgcctctaa gaaagggttc tagtaaatgg attttcttct    720

aagccactct cagaaaacag tttcttggtc atacacagag aagtactaga tttggtgtgt    780

cttagaatat tcttccttcc ttgagctgtg ttgtattttt cttttcaaga ttaaaaatac    840

tgccattgg                                                            849


<210>  2791
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  2791

Met Glu Gly Leu Ser Asp Val Ala Ser Phe Ala Thr Lys Leu Lys Asn 
1               5                   10                  15


Thr Leu Ile Gln Tyr His Ser Ile Glu Glu Asp Lys Trp Arg Val Ala 
            20                  25                  30


Lys Lys Thr Lys Asp Val Thr Val Trp Arg Lys Pro Ser Glu Glu Phe 
        35                  40                  45


Asn Gly Tyr Leu Ile Ala Val 
    50                  55


<210>  2792
<211>  686
<212>  DNA
<213>  Homo sapiens

<400>  2792
agttggctgc gaccagcggt gacttacaag ttggctgctg tcgcctgcgc atcggcgggc     60

cgggaggctg agcagtactg ttgagagcgg tgtgaggtgc ttggtagcgc gccgtagctg    120

cttccacgtc cttgcttcac ctcaggtaaa gaaagatgta actgtttgga gaaaaccctc    180

agaagaattt aatggatatc taattgctgt gtgatgcgtt acactactgc tggtcagctt    240

tggaatataa tttccccaag agaatttgtt gatttctcct atactgtggg ctataaagaa    300

gggcttttat cttgtggtaa taatctcaac atgttatgct ttttttcagt atggtttaaa    360

tatttgtgtt ttcttggctg gatgtctctt tccttgtgag atatattttc aactctgact    420

ctgtaatcac taacattttt tgcaagtgct aaactctagg gagtaaaata gcaatatcaa    480

aagagttttg aaacccttct gataagtttt tgttcccagt tacacagtat cctctaggtc    540

agaggtagca aatgtggatc acatgactgc ctctaagaaa gggttctagt aaatggattt    600

tcttctaagc cactctcaga aaacagtttc ttggtcatac acagagaagt actagatttg    660

gtgtgtctta gaatattctt ccttcc                                         686


<210>  2793
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  2793

Met Arg Tyr Thr Thr Ala Gly Gln Leu Trp Asn Ile Ile Ser Pro Arg 
1               5                   10                  15


Glu Phe Val Asp Phe Ser Tyr Thr Val Gly Tyr Lys Glu Gly Leu Leu 
            20                  25                  30


Ser Cys Gly Asn Asn Leu Asn Met Leu Cys Phe Phe Ser Val Trp Phe 
        35                  40                  45


Lys Tyr Leu Cys Phe Leu Gly Trp Met Ser Leu Ser Leu 
    50                  55                  60


<210>  2794
<211>  689
<212>  DNA
<213>  Homo sapiens

<400>  2794
aggctgagca gtactgttga gagcggtgtg aggtgcttgg tagcgcgccg tagctgcttc     60

cacgtccttg cttcacctca ggtaaagaga gaagtaatgg aaggcctgtc tgatgttgct    120

tcttttgcaa ctaaacttaa aaacactctc atccagtacc atagcattga agaagataag    180

tggcgagttg ctaagaaaac gaaagatgta actgtttgga gaaaaccctc agaagaattt    240

aatggatatc tagtcttaaa gggatatgtg atcaaaagag aattgctgtg tgatgcgtta    300

cactactgct ggtcagcttt ggaatataat ttccccaaga gaatttgttg atttctccta    360

tactgtgggc tataaagaag ggcttttatc ttgtggtaat aatctcaaca tgttatgctt    420

tttttcagta tggtttaaat atttgtgttt tcttggctgg atgtctcttt ccttgtgaga    480

tatattttca actctgactc tgtaatcact aacatttttt gcaagtgcta aactctaggg    540

agtaaaatag caatatcaaa agagttttga aacccttctg ataagttttt gttcccagtt    600

acacagtatc ctctaggtca gaggtagcaa atgtggatca catgactgcc tctaagaaag    660

ggttctagta aatggatttt cttctaagc                                      689


<210>  2795
<211>  84
<212>  PRT
<213>  Homo sapiens

<400>  2795

Met Glu Gly Leu Ser Asp Val Ala Ser Phe Ala Thr Lys Leu Lys Asn 
1               5                   10                  15


Thr Leu Ile Gln Tyr His Ser Ile Glu Glu Asp Lys Trp Arg Val Ala 
            20                  25                  30


Lys Lys Thr Lys Asp Val Thr Val Trp Arg Lys Pro Ser Glu Glu Phe 
        35                  40                  45


Asn Gly Tyr Leu Val Leu Lys Gly Tyr Val Ile Lys Arg Glu Leu Leu 
    50                  55                  60


Cys Asp Ala Leu His Tyr Cys Trp Ser Ala Leu Glu Tyr Asn Phe Pro 
65                  70                  75                  80


Lys Arg Ile Cys 



<210>  2796
<211>  630
<212>  DNA
<213>  Homo sapiens

<400>  2796
agttggctgc gaccagcggt gacttacaag ttggctgctg tcgcctgcgc atcggcgggc     60

cgggaggctg agcagtactg ttgagagcgg tgtgaggtgc ttggtagcgc gccgtagctg    120

cttccacgtc cttgcttcac ctcaggtaaa gaaagatgta actgtttgga gaaaaccctc    180

agaagaattt aatggatatc tctacaaagc ccaaggtgtt atagatgacc ttgtctatag    240

tataatagac catatacgcc cagggccttg tcgtttggat tgggacagct tgatgacttc    300

tttggatatt ctggagaact ttgaagagaa ttgctgtgtg atgcgttaca ctactgctgg    360

tcagctttgg aatataattt ccccaagaga atttgttgat ttctcctata ctgtgggcta    420

taaagaaggg cttttatctt gtggtaataa tctcaacatg ttatgctttt tttcagtatg    480

gtttaaatat ttgtgttttc ttggctggat gtctctttcc ttgtgagata tattttcaac    540

tctgactctg taatcactaa cattttttgc aagtgctaaa ctctagggag taaaatagca    600

atatcaaaag agttttgaaa cccttctgat                                     630


<210>  2797
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  2797

Met Thr Ser Leu Asp Ile Leu Glu Asn Phe Glu Glu Asn Cys Cys Val 
1               5                   10                  15


Met Arg Tyr Thr Thr Ala Gly Gln Leu Trp Asn Ile Ile Ser Pro Arg 
            20                  25                  30


Glu Phe Val Asp Phe Ser Tyr Thr Val Gly Tyr Lys Glu Gly Leu Leu 
        35                  40                  45


Ser Cys Gly Asn Asn Leu Asn Met Leu Cys Phe Phe Ser Val Trp Phe 
    50                  55                  60


Lys Tyr Leu Cys Phe Leu Gly Trp Met Ser Leu Ser Leu 
65                  70                  75


<210>  2798
<211>  404
<212>  DNA
<213>  Homo sapiens

<400>  2798
acaagttggc tgctgtcgcc tgcgcatcgg cgggccggga ggctgagcag tactgttgag     60

agcggtgtga ggtgcttggt agcgcgccgt agctgcttcc acgtccttgc ttcacctcag    120

gtaaagagag aagtaatgga aggcctgtct gatgttgctt cttttgcaac taaacttaaa    180

aacactctca tccagtacca tagcattgaa gaagataagt ggcgagttgc taagaaaacg    240

aaagatgtaa ctgtttggag aaaaccctca gaagaattta atggatatct gtaagtaact    300

ttttatagac ttacacagct cttaagacat ttcaaaactt atatccattg tcactaagta    360

gtcattgcta gtaagattta gctttttaag agttctttaa cttt                     404


<210>  2799
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  2799

Met Glu Gly Leu Ser Asp Val Ala Ser Phe Ala Thr Lys Leu Lys Asn 
1               5                   10                  15


Thr Leu Ile Gln Tyr His Ser Ile Glu Glu Asp Lys Trp Arg Val Ala 
            20                  25                  30


Lys Lys Thr Lys Asp Val Thr Val Trp Arg Lys Pro Ser Glu Glu Phe 
        35                  40                  45


Asn Gly Tyr Leu 
    50


<210>  2800
<211>  5525
<212>  DNA
<213>  Homo sapiens

<400>  2800
tgaagtgtca aaaagaaagt taatttaatt ggccttcatg aaaaacacaa acttgaattc     60

agacaatgaa tgaatggaat gcagtatcag ccacgtgtcc atgtttggag tgtcagttga    120

tgagcaccaa gaagaatggg cagctttaca gttcagcaag cacagatgga ctctagatag    180

atggatcagc ttaccagttt tctgaccctc atattatcag cactcaaaag cttcagtgat    240

agggtcattg tcagttccta atattctgaa ctagttagaa aactgagggc acagaaactc    300

atgggttcat gtgggtcttg ttactgctgt ggcccctagg agctgcaggg agacctggct    360

acagggccac ttgcctgcat ggagcttatt ctgcacttat ccctcaccct tctatcatct    420

tccttggctg attctgacag ccatcaaatg ccctcccaga tgtgctcact gccaccccca    480

tttcctttgt tgacagcact actggatatt atgctaaatg ttggttttgt ttgttgttta    540

gtctgttgat agatgttcca gcagctatta catttgactt aacctatata tttctttttt    600

gttgttgccc ttaaaaagca cactgtgttt agtttgcgag ggctgccata acaaagtgcc    660

acagactggg cagcttacac aacagaaatt tattttctaa caatctggac gctggaagtc    720

tgagatcaag atgttggcag ggttggtttc ttctgaggcc tcccttctgg gcttgtagat    780

ggctgtcttc tccctgtgtc ttcatatggt ctttcctctg tgtatctgtg tcctaatctc    840

ttcttagaag gacatgggtc acttgagatt agggcccacc ctgatgatgt ccttatttta    900

acttaattgc ctctgcaaag atcctgtttc caaatacaat cacattctga ggtattggtg    960

gttaggactt ccccatatga attttgaggt gatacaagtc agcccataac acatttttaa   1020

aagtaaattt ttgtggattg atcacccctg ctgtacctgc cccaccccca gacgtgagca   1080

tctagaaggc agaaactctg tttctcttgc aattcccaca acctaacagt gtccagcact   1140

ttgcagctat ttcatgaact cttgctgcat gaatgcaaaa aaggttggta agaaacttga   1200

agttgaaaag tggcactatt tctgactgcc agaagtagca cctggcgagt agactagaac   1260

atgttccgat gagaagaaga ggcaaagaaa atacagtaca tttaaaccga gacagctttt   1320

gacagaaagg caaatgattg ttgcttggga tcacccattc tccacatcca gcactgggaa   1380

tggaatggaa gttcaggccc ttgcggaata ccaaaggtca ggtcagtttt tactgtagat   1440

actggacttt gcctcttagg gtgaatactt gtttgacttc aagcggggag agtatacttt   1500

ttaaccaatg acttgctgat tttgcagtta agaaagaaaa acagaatcca ctgaaaataa   1560

aatttctatt tgaaagtttc ataagtgtaa ttgactaacg gtgagtcctc ccccagctgt   1620

tactggtatt tcaatgttta agaaattatt ttatttacac taaatagtat caacaattcc   1680

ctatcttata ctggcaggca gaaactgaag aggttgtatc aactggcagt ttgcactgaa   1740

agaaaacaat cttaaatcac ttttaatctt gcagagcatt tttgaaggtc aaggttgaaa   1800

tcactggcag gaaagtaggt gaacaaaatg gtttgaccct gcctgaacta gacttgcact   1860

gatttgtaga gctggagtgg aagagagcta aaatagtagc gctttcctta aaagacaccc   1920

acaccccacc acctcaccag cagcacacca gcggcacgag cagtataacc acagacattc   1980

gtcactgtgc cagatcaggg cataattctc ttaaggcagc tgaggccttc acattagttc   2040

ttgcctcatt caggcatcca gaggtcctct ctctttgata ctggtgacat aaaccagagg   2100

ggcaagacta ggcatagttc cttgatgagt tcagtggtgc ctcaccgtac ccttagaaag   2160

ccagccctgc tgtgctaggt cttgtctcac acaaagacat gctcccaggg gtgggcaccg   2220

tggatcatgg tattcaggtc ttctgctatt ttaagttctt tcttctctaa atatgtgaat   2280

aatattttaa gcatagtgtt atttgttctt tttccagaag ttcccttctg gaaaagcata   2340

tctttgtata attgtaggaa aaataatctt gacttacttg gtccaaagca cattattaac   2400

tggggattaa tttcctagta gtcatctgtc gggagggctg atccaccccg aggcacatta   2460

actggcgtga ctttcaggac ggcggggctg tgggagccac tggacacatc tgccccccaa   2520

cccctagcct cttgaattac tcaagtccct cagctctgtt ggcacaaata cgtgctggat   2580

gatagaagaa ccgtttttcc catggatgaa ctttttttgg cttgaattct tacaaggcct   2640

gacttctgga tctggagaaa gaagacttct ttgtgtccca tcttcaaaat gcctcctcca   2700

cttgttgcag aagcctaaaa ttcctttagt tggggcagaa agcctattat tatttaaaaa   2760

aaaaaaaaat agtgggaggg tgtgtggatt gaaatcagtc aggggaagag gattgaaatc   2820

tagtaaatgc aggactccat agggagaacg cacagaactc tgtctcctca ggagcacctc   2880

tctccacggg catggtgggc tccaggccct cagggtgctt cagtagcaca cctccctgtg   2940

ggccctacta ccattgcctc atgagggtcc agtctgtatg cttgtcttcc acacagcaag   3000

ttaatgaagg gtgagatggg cagggactgt tactgtttct gtttcaatct ctctctaagc   3060

ttgaaatcga atagagtact ccagccatag taggcactca gaaaatgaat aattaatgaa   3120

gaaatgtata ttatctggga ccttgaaaca gaaaaaatgg taaaaatggt aaattcaaat   3180

ctgaaataat cgtcactttc tttttttctg gaagtgcctc ttcccaaatc cctagctctt   3240

ccttttgttt tgttgtgtat gtttcatgga ggtagaagat tagtactgag actgagattt   3300

aaatagagag atacactaac gttctgtata ttcacttttg aacagagtaa gtctgaactg   3360

gagcagtttt aaggcaagct gtgtaaagac tataattgtt gagttaacat ttatcaactt   3420

ttggttttcc ttcttttctt gcctgtgaca attaacagcc attgaactct tcatttgtcc   3480

aaaacctaag tttgtcctat cctgaaccat ggtaactggt tgactgtggg gtgaggtggg   3540

gtcgggctgg cagcattatt ttaaagacac tgggattaca gtggatttcc tttttttttt   3600

ttttttttta aattttggga ctgtgtacca agattccaag attgaaatta ttttcacaac   3660

tgcaagtaac tacccaatat tatgcttttg gaaattgaat ctagaccctt aagggtgtgt   3720

gagtggtgaa ttatattttt atttaatttt ctggtttggt cccattggta tttaatgata   3780

ccaaaacaac ctctaaaatc acaacctaag attggaatat taaagtacat catggttata   3840

tatgtgcaaa aaatgctgta tgctctcaaa gtccgagact tttaagtaaa aaattgaggc   3900

ataccagatg tttaatatgg aaaatctgta cagtaagtaa gactttttaa agttgaataa   3960

tctgttgcat ttagttcacc cctgggttgc tgaaaatatt tattcaattt caagttgttt   4020

ggaagttact ggtttctgaa ttcttaaaaa gaaattcaga tgtgttaatt tataggccac   4080

aaagtaagat tatcacttta atccaagtac tttacatcta gtcaaactgg cttattaaaa   4140

ctgtcttgtt agaacatgtg acttgagcaa caaaaaaaaa agcccacatg ttttaaaacc   4200

acaaaggata atttcttcca agaaaatgtc agtaattaaa actccagagt tcagctgaaa   4260

gagagaccat cgtcaaatct tcactgtgtt catacctgta cagggcataa aatctatctg   4320

ttgtaaatga atacctgtat tgtgcatcat gtgggcaggt gtgcttcact gtgctgtgct   4380

tctgctgtct ggttgtgatg gagagctcct ctccactgtt ggcgctgcag cagtgtgtcc   4440

gggaagccac gtggcggcgg atcagtagtc acactgagat tgagttattc ttaattttta   4500

tataactgtc tttagctctt cttttgacag ggcaggcctt gttctgaact gtttcgcttc   4560

tgactgttaa acaccgatga cgcatgcact gcacttcttc gttttcttct tgctccccca   4620

ttggcctgag tttcttgtgc attactcctc tccctccttc gttagaatag gtatatcagc   4680

agatgataag gtgatgatga gcagagcctt ctagaggtct catgtgaccc tgaaacctgg   4740

caattcaggg gattcatgca ctccctgtgc atgagaaatg tcttctggtt tctcctcatc   4800

cattacggga gtgaaatttt aacttggctt gtacacaggt tgcttatttg gctggtgggt   4860

tcagatattg gagtttcacc tcaacagaga ctaaggaaca gacgtggagc tggagaatct   4920

gctcccaata caggttagtc catggctgtt tgcaggatgc ctcagttctt ctactcatga   4980

gcctctccct agtgctgctt gagtgtcccc ataacttctg gcttcctgtt ctcatgctcc   5040

tgtcctgctt cgctcctcac atttgacaag gagctcctcc tcctatgaaa ggccacttgt   5100

cccatagctt tcttccatcc catcgtgtct cagcatctca gggatcttgc actgatcatt   5160

gtcccatttt cagagccggt ccaagaggca gattacctga gcagcagcct ggcatgccaa   5220

tttgtaagaa gtgaagagca tcaagttggc tgctgtcgcc tgcgcatcgg cgggccggga   5280

ggctgagcag tactgttgag agcggtgtga ggtgcttggt agcgcgccgt agctgcttcc   5340

acgtccttgc ttcacctcag gtaaaggtaa ggagagccac ggagccgcgg caggattggg   5400

gtggcccgtg tggagggcga ctgtggcgcc cggggcgtcc tgccaggtgc gtcttctgga   5460

cctgctccag accatggatc tggggagctc gcggtggacg ttggggatgg cgggccccgg   5520

cgtcc                                                               5525


<210>  2801
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  2801

Met His Ser Leu Cys Met Arg Asn Val Phe Trp Phe Leu Leu Ile His 
1               5                   10                  15


Tyr Gly Ser Glu Ile Leu Thr Trp Leu Val His Arg Leu Leu Ile Trp 
            20                  25                  30


Leu Val Gly Ser Asp Ile Gly Val Ser Pro Gln Gln Arg Leu Arg Asn 
        35                  40                  45


Arg Arg Gly Ala Gly Glu Ser Ala Pro Asn Thr Gly 
    50                  55                  60


<210>  2802
<211>  3390
<212>  DNA
<213>  Homo sapiens

<400>  2802
gctggccagc catggcccgg ccgggctgca gcagaggcag tgagctccct gtcaccagag     60

gtgtatgagc agaggctggg ggctctctag ggagggaagc cacggagggg ctgtctgccc    120

tcctggcccc tctgaggctg tgagcagtcc cttctacttc ctgtgcggct ttgcccatca    180

cttggcccgg ttgagcctac tgcaggcatc tgaccagctg caggctctga ggtgagtgtg    240

agggcaaagg tttggacacc tctggctcca aagtggggct ggaggctaga gcaggggtgg    300

tctctgtaag agtctgatct caagggggcc tcataccaac aacatcacct tctttttgga    360

gaggcagcct agtggagtgg ctggtagcct taggccttct ggggccaggg aggacagaga    420

ccagagggag ggattattct taagccagcc acccctcaca ggcttcaact ttttctaaaa    480

ccaggaactg gaaggagaaa gatgggaaga aataggagag aagagagcct gggtttccat    540

tttgctcccg ccacttggta gctctgtggc tttggcaggt cacttaccct tttttggttc    600

gtaagtcact taccctcttt gtcacttacc ctctttggta tcatctgtaa gataggatga    660

cgggccaggc gcgcacctgt aatcccagat actcgggagg ctgaggcagg agaatcgctt    720

gaactcagga ggcagaggtt gcagtgagct gagatcatgc cactacactc cagcctgggt    780

gacaggatga gactccattt aaaaaaaaaa aagaggatga caacactgcc tgtctcactg    840

gaatcttgta aggattaaat ggttactgtt tttaacgtag ttggaagagt ttgtggtcct    900

gtgtttgtta aatatacaca aattaacttc ccagctcacc catgcctagt attatgcaag    960

gggcttcaca tcaattacct tgtttggtct tcaccacagc cacatgagct tggaatgact   1020

attattaggg aaagtggacc caagaaggtc aagttccttg cctgaggtca cacagctagt   1080

aaaaggcaga gcaaaggttg aaactcagga tggtctgtct ccaggaccgg ggctctccac   1140

cactcgggcc tgcctattcc agggctggca gcctctctac agaggtgaag cgtctactgg   1200

atcacttttg accaacaaca catcagccgg cagaggaagg aggggtgggc caagaagggc   1260

cccttccctc tcaggccgga gagattcctc tgactaattt gctgagtgac ttcgatggca   1320

aactgcagcc ctgttccctc cagactcctc cgtcttgctc atgactgggt cccctgggca   1380

gagccaggtc ctggcagaga gcagatatcc agtaaatacc tcttggccct aagaatgact   1440

gggaacactc atgtagcgag aacaccttcc tgtgtgttat ctcatctcat cctcacagca   1500

gcccagagag gttttcctgg caaaggagcc tttggtggtg gatgtcttca tggcacatgt   1560

gaggaccatc aataccaaat ctcccttcat ctgcttggag ttccctgcat cagtacatga   1620

tcccatatag ggcaggcaga agatggctgt gccacccacg tatgccgatc ttggcaaatc   1680

tgccagggat gtcttcacca agggctatgg atttggctta ataaagcttg atttgaaaac   1740

aaaatctgag aatggattgg aatttacaag ctcaggctca gccaacactg agaccaccaa   1800

agtgacgggc agtctggaaa ccaagtacag atggactgag tacggcctga cgtttacaga   1860

gaaatggaat accgacaata cactaggcac cgagattact gtggaagatc agcttgcacg   1920

tggactgaag ctgaccttcg attcatcctt ctcacctaac actgggaaaa aaaatgctaa   1980

aatcaagaca gggtacaagc gggagcacat taacctgggc tgcgacatgg atttcgacat   2040

tgctgggcct tccatccggg gtgctctggt gctaggttac gagggctggc tggccggcta   2100

ccagatgaat tttgagactg caaaatcccg agtgacccag agcaactttg cagttggcta   2160

caagactgat gaattccagc ttcacactaa tgtgaatgac gggacagagt ttggcggctc   2220

catttaccag aaagtgaaca agaagttgga gaccgctgtc aatcttgcct ggacagcagg   2280

aaacagtaac acgcgcttcg gaatagcagc caagtatcag attgaccctg acgcctgctt   2340

ctcggctaaa gtgaacaact ccagcctgat aggtttagga tacactcaga ctctaaagcc   2400

aggtattaaa ctgacactgt cagctcttct ggatggcaag aacgtcaatg ctggtggcca   2460

caagcttggt ctaggactgg aatttcaagc ataaatgaat actgtacaat tgtttaattt   2520

taaactattt tgcagcatag ctaccttcag aatttagtgt atcttttaat gttgtatgtc   2580

tgggatgcaa gtattgctaa atatgttagc cctccaggtt aaagttgatt cagctttaag   2640

atgttaccct tccagaggta cagaagaaac ctatttccaa aaaaggtcct ttcagtggta   2700

gactcgggga gaacttggtg gcccctttga gatgccaggt ttctttttta tctagaaatg   2760

gctgcaagtg gaagcggata atatgtaggc actttgtaaa ttcatattga gtaaatgaat   2820

gaaattgtga tttcctgaga atcgaacctt ggttccctaa ccctaattga tgagaggctc   2880

gctgcttgat ggtgtgtaca aactcacctg aatgggactt ttttagacag atcttcatga   2940

cctgttccca ccccagttca tcatcatctc ttttacacca aaaggtctgc agggtgtggt   3000

aactgtttct tttgtgccat tttggggtgg agaaggtgga tgtgatgaag ccaataattc   3060

aggacttatt ccttcttgtg ttgtgttttt ttttggccct tgcaccagag tatgaaatag   3120

cttccaggag ctccagctat aagcttggaa gtgtctgtgt gattgtaatc acatggtgac   3180

aacactcaga atctaaattg gacttctgtt gtattctcac cactcaattt gttttttagc   3240

agtttaatgg gtacatttta gagtcttcca ttttgttgga attagatcct ccccttcaaa   3300

tgctgtaatt aacaacactt aaaaaacttg aataaaatat tgaaacctca tccttcttct   3360

gttgtcttta ttaataaaat ataaataaac                                    3390


<210>  2803
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  2803

Met Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Lys Ser Ala Arg Asp 
1               5                   10                  15


Val Phe Thr Lys Gly Tyr Gly Phe Gly Leu Ile Lys Leu Asp Leu Lys 
            20                  25                  30


Thr Lys Ser Glu Asn Gly Leu Glu Phe Thr Ser Ser Gly Ser Ala Asn 
        35                  40                  45


Thr Glu Thr Thr Lys Val Thr Gly Ser Leu Glu Thr Lys Tyr Arg Trp 
    50                  55                  60


Thr Glu Tyr Gly Leu Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr 
65                  70                  75                  80


Leu Gly Thr Glu Ile Thr Val Glu Asp Gln Leu Ala Arg Gly Leu Lys 
                85                  90                  95


Leu Thr Phe Asp Ser Ser Phe Ser Pro Asn Thr Gly Lys Lys Asn Ala 
            100                 105                 110


Lys Ile Lys Thr Gly Tyr Lys Arg Glu His Ile Asn Leu Gly Cys Asp 
        115                 120                 125


Met Asp Phe Asp Ile Ala Gly Pro Ser Ile Arg Gly Ala Leu Val Leu 
    130                 135                 140


Gly Tyr Glu Gly Trp Leu Ala Gly Tyr Gln Met Asn Phe Glu Thr Ala 
145                 150                 155                 160


Lys Ser Arg Val Thr Gln Ser Asn Phe Ala Val Gly Tyr Lys Thr Asp 
                165                 170                 175


Glu Phe Gln Leu His Thr Asn Val Asn Asp Gly Thr Glu Phe Gly Gly 
            180                 185                 190


Ser Ile Tyr Gln Lys Val Asn Lys Lys Leu Glu Thr Ala Val Asn Leu 
        195                 200                 205


Ala Trp Thr Ala Gly Asn Ser Asn Thr Arg Phe Gly Ile Ala Ala Lys 
    210                 215                 220


Tyr Gln Ile Asp Pro Asp Ala Cys Phe Ser Ala Lys Val Asn Asn Ser 
225                 230                 235                 240


Ser Leu Ile Gly Leu Gly Tyr Thr Gln Thr Leu Lys Pro Gly Ile Lys 
                245                 250                 255


Leu Thr Leu Ser Ala Leu Leu Asp Gly Lys Asn Val Asn Ala Gly Gly 
            260                 265                 270


His Lys Leu Gly Leu Gly Leu Glu Phe Gln Ala 
        275                 280


<210>  2804
<211>  3349
<212>  DNA
<213>  Homo sapiens

<400>  2804
gctggccagc catggcccgg ccgggctgca gcagaggcag tgagctccct gtcaccagag     60

gtgtatgagc agaggctggg ggctctctag ggagggaagc cacggagggg ctgtctgccc    120

tcctggcccc tctgaggctg tgagcagtcc cttctacttc ctgtgcggct ttgcccatca    180

cttggcccgg ttgagcctac tgcaggcatc tgaccagctg caggctctga ggtgagtgtg    240

agggcaaagg tttggacacc tctggctcca aagtggggct ggaggctaga gcaggggtgg    300

tctctgtaag agtctgatct caagggggcc tcataccaac aacatcacct tctttttgga    360

gaggcagcct agtggagtgg ctggtagcct taggccttct ggggccaggg aggacagaga    420

ccagagggag ggattattct taagccagcc acccctcaca ggcttcaact ttttctaaaa    480

ccaggaactg gaaggagaaa gatgggaaga aataggagag aagagagcct gggtttccat    540

tttgctcccg ccacttggta gctctgtggc tttggcaggt cacttaccct tttttggttc    600

gtaagtcact taccctcttt gtcacttacc ctctttggta tcatctgtaa gataggatga    660

cgggccaggc gcgcacctgt aatcccagat actcgggagg ctgaggcagg agaatcgctt    720

gaactcagga ggcagaggtt gcagtgagct gagatcatgc cactacactc cagcctgggt    780

gacaggatga gactccattt aaaaaaaaaa aagaggatga caacactgcc tgtctcactg    840

gaatcttgta aggattaaat ggttactgtt tttaacgtag ttggaagagt ttgtggtcct    900

gtgtttgtta aatatacaca aattaacttc ccagctcacc catgcctagt attatgcaag    960

gggcttcaca tcaattacct tgtttggtct tcaccacagc cacatgagct tggaatgact   1020

attattaggg aaagtggacc caagaaggtc aagttccttg cctgaggtca cacagctagt   1080

aaaaggcaga gcaaaggttg aaactcagga tggtctgtct ccaggaccgg ggctctccac   1140

cactcgggcc tgcctattcc agggctggca gcctctctac agaggtgaag cgtctactgg   1200

atcacttttg accaacaaca catcagccgg cagaggaagg aggggtgggc caagaagggc   1260

cccttccctc tcaggccgga gagattcctc tgactaattt gctgagtgac ttcgatggca   1320

aactgcagcc ctgttccctc cagactcctc cgtcttgctc atgactgggt cccctgggca   1380

gagccaggtc ctggcagaga gcagatatcc agtaaatacc tcttggccct aagaatgact   1440

gggaacactc atgtagcgag aacaccttcc tgtgtgttat ctcatctcat cctcacagca   1500

gcccagagag gttttcctgg caaaggagcc tttggtggtg gatgtcttca tggcacatgt   1560

gaggaccatc aataccaaat ctcccttcat ctgcttggag ttccctgcat cagtacatga   1620

tcccatatag ggcaggcaga agatggctgt gccacccacg tatgccgatc ttggcaaatc   1680

tgccagggat gtcttcacca agggctatgg atttggctta ataaagcttg atttgaaaac   1740

aaaatctgag aatggattgg aatttacaag ctcaggctca gccaacactg agaccaccaa   1800

agtgacgggc agtctggaaa ccaagtacag atggactgag tacggcctga cgtttacaga   1860

gaaatggaat accgacaata cactaggcac cgagattact gtggaagatc agcttgcacg   1920

tggactgaag ctgaccttcg attcatcctt ctcacctaac actgggaaaa aaaatgctaa   1980

aatcaagaca gggtacaagc gggagcacat taacctgggc tgcgacatgg atttcgacat   2040

tgctgggcct tccatccggg gtgctctggt gctaggttac gagggctggc tggccggcta   2100

ccagatgaat tttgagactg caaaatcccg agtgacccag agcaactttg cagttggcta   2160

caagactgat gaattccagc ttcacactaa tgtgaatgac gggacagagt ttggcggctc   2220

catttaccag aaagtgaaca agaagttgga gaccgctgtc aatcttgcct ggacagcagg   2280

aaacagtaac acgcgcttcg gaatagcagc caagtatcag attgaccctg acgcctgctt   2340

ctcggctaaa gtgaacaact ccagcctgat aggtttagga tacactcaga ctctaaagcc   2400

aggtattaaa ctgacactgt cagctcttct ggatggcaag aacgtcaatg ctggtggcca   2460

caagcttggt ctaggactgg aatttcaagc ataaatgaat actgtacaat tgtttaattt   2520

taaactattt tgcagcatag ctaccttcag aatttagtgt atcttttaat gttgtatgtc   2580

tgggatgcaa gtattgctaa atatgttagc cctccaggtt aaagttgatt cagctttaag   2640

atgttaccct tccagaggta cagaagaaac ctatttccaa aaaaggtcct ttcagtggta   2700

gactcgggga gaacttggtg gcccctttga gatgccaggt ttctttttta tctagaaatg   2760

gctgcaagtg gaagcggata atatgtaggc actttgtaaa ttcatattga gtaaatgaat   2820

gaaattgtga tttcctgaga atcgaacctt ggttccctaa ccctaattga tgagaggctc   2880

gctgcttgat ggtgtgtaca aactcacctg aatgggactt ttttagacag atcttcatga   2940

cctgttccca ccccagttca tcatcatctc ttttacacca aaaggtctgc agggtgtggt   3000

aactgtttct tttgtgccat tttggggtgg agaaggtgga tgtgatgaag ccaataattc   3060

aggacttatt ccttcttgtg ttgtgttttt ttttggccct tgcaccagag tatgaaatag   3120

cttccaggag ctccagctat aagcttggaa gtgtctgtgt gattgtaatc acatggtgac   3180

aacactcaga atctaaattg gacttctgtt gtattctcac cactcaattt gttttttagc   3240

agtttaatgg gtacatttta gagtcttcca ttttgttgga attagatcct ccccttcaaa   3300

tgctgtaatt aacaacactt aaaaaacttg aataaaatat tgaaacctc               3349


<210>  2805
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  2805

Met Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Lys Ser Ala Arg Asp 
1               5                   10                  15


Val Phe Thr Lys Gly Tyr Gly Phe Gly Leu Ile Lys Leu Asp Leu Lys 
            20                  25                  30


Thr Lys Ser Glu Asn Gly Leu Glu Phe Thr Ser Ser Gly Ser Ala Asn 
        35                  40                  45


Thr Glu Thr Thr Lys Val Thr Gly Ser Leu Glu Thr Lys Tyr Arg Trp 
    50                  55                  60


Thr Glu Tyr Gly Leu Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr 
65                  70                  75                  80


Leu Gly Thr Glu Ile Thr Val Glu Asp Gln Leu Ala Arg Gly Leu Lys 
                85                  90                  95


Leu Thr Phe Asp Ser Ser Phe Ser Pro Asn Thr Gly Lys Lys Asn Ala 
            100                 105                 110


Lys Ile Lys Thr Gly Tyr Lys Arg Glu His Ile Asn Leu Gly Cys Asp 
        115                 120                 125


Met Asp Phe Asp Ile Ala Gly Pro Ser Ile Arg Gly Ala Leu Val Leu 
    130                 135                 140


Gly Tyr Glu Gly Trp Leu Ala Gly Tyr Gln Met Asn Phe Glu Thr Ala 
145                 150                 155                 160


Lys Ser Arg Val Thr Gln Ser Asn Phe Ala Val Gly Tyr Lys Thr Asp 
                165                 170                 175


Glu Phe Gln Leu His Thr Asn Val Asn Asp Gly Thr Glu Phe Gly Gly 
            180                 185                 190


Ser Ile Tyr Gln Lys Val Asn Lys Lys Leu Glu Thr Ala Val Asn Leu 
        195                 200                 205


Ala Trp Thr Ala Gly Asn Ser Asn Thr Arg Phe Gly Ile Ala Ala Lys 
    210                 215                 220


Tyr Gln Ile Asp Pro Asp Ala Cys Phe Ser Ala Lys Val Asn Asn Ser 
225                 230                 235                 240


Ser Leu Ile Gly Leu Gly Tyr Thr Gln Thr Leu Lys Pro Gly Ile Lys 
                245                 250                 255


Leu Thr Leu Ser Ala Leu Leu Asp Gly Lys Asn Val Asn Ala Gly Gly 
            260                 265                 270


His Lys Leu Gly Leu Gly Leu Glu Phe Gln Ala 
        275                 280


<210>  2806
<211>  3276
<212>  DNA
<213>  Homo sapiens

<400>  2806
cccgccagct cgcggagccg ctctgccccg cgccctagcc cgcgcctgca gcccgcccag     60

gcggagtcag cccgcgctcc gcccgccgcg atccgagctc ggaggttcgg actccgggct    120

cgccgccccc cgggccggct ccgcgccccg cactcccggc gcccagcgcc ccgcgccccg    180

gcgggcggag cgcaccatgc cgcagctgga ctccggcggg ggcggcgcgg gcggcggcga    240

cgacctcggc gcgccggacg agctgctggc cttccaggat gaaggcgagg agcaggacga    300

caagagccgc gacagcgccg ccggtcccga gcgcgacctg gccgagctca agtcgtcgct    360

cgtgaacgag tccgagggcg cggccggcgg cgcagggatc ccgggggtcc cgggggccgg    420

cgccggggcc cgcggcgagg ccgaggctct cgggcgggaa cacgctgcgc agagactctt    480

cccggacaaa cttccagagc ccctggagga cggcctgaag gccccggagt gcaccagcgg    540

catgtacaaa gagaccgtct actccgcctt caatctgctc atgcattacc cacccccctc    600

gggagcaggg cagcaccccc agccgcagcc cccgctgcac aaggccaatc agccccccca    660

cggtgtcccc caactctctc tctacgaaca tttcaacagc ccacatccca cccctgcacc    720

tgcggacatc agccagaagc aagttcacag gcctctgcag acccctgacc tctctggctt    780

ctactccctg acctcaggca gcatggggca gctcccccac actgtgagct ggttcaccca    840

cccatccttg atgctaggtt ctggtgtacc tggtcaccca gcagccatcc cccacccggc    900

cattgtgccc ccctcaggga agcaggagct gcagcccttc gaccgcaacc tgaagacaca    960

agcagagtcc aaggcagaga aggaggccaa gaagccaacc atcaagaagc ccctcaatgc   1020

cttcatgctg tacatgaagg agatgagagc caaggtcatt gcagagtgca cacttaagga   1080

gagcgctgcc atcaaccaga tcctgggccg caggtggcac gcgctgtcgc gagaagagca   1140

ggccaagtac tatgagctgg cccgcaagga gaggcagctg cacatgcagc tatacccagg   1200

ctggtcagcg cgggacaact acgggaagaa gaagaggcgg tcgagggaaa agcaccaaga   1260

atccaccaca ggaggaaaaa gaaatgcatt cggtacttac ccggagaagg ccgctgcccc   1320

agccccgttc cttccgatga cagtgctcta ggctgccccg ggtccccagc tccccaggac   1380

tcaccctcat accatctgct gccccgcttc cccacagaac tgcttactag ccctgcggag   1440

ccggcaccta catccccagg tctctccact gctctcagcc tcccaacccc agggccccca   1500

caggcccccc gcagcaccct gcagagcaca caggtacagc aacaggaatc tcagagacag   1560

gtggcctagc aggcacagga cacctggccg cctccaggag cctaccccct gaaagtgaca   1620

gagacccaga tctcatggaa actggccagg ggtcctgtta acgtcatctc agggtccaga   1680

ccctgaagat ttcagaggct gcaggacttc tgcctgaacc tggggtcatc gattcaaact   1740

gctccaagtg gtgggaatca gatctgtctt gatgtgtcat ctaattaagg gaatcccttg   1800

tacctatggc tgcctgcatc tattctttgt accatctgtc ttgccagcca gaagcctctg   1860

cctccctagc ttttctgcta taggtcagag atgggctgaa ctgagcctag ctaccttctc   1920

tacccatctc ccccatcccc cactgccaca ccctccccat tcagacactt catggaccaa   1980

gaatgagctg gtttgtcaaa caacatgtga gcatggtcac aagcacaaag ctcaagatga   2040

cagctcttct aaggaaatgg agaagctctg tttataaaaa caaaaacaaa accagctgct   2100

actcataagt tggaccagag gaagcccctt actatgatct caggagcttg caagaagcag   2160

gaaggggaat ggaataggtt aagtttaggc ctatcaacct aagcaacaga aataatctga   2220

cactacctta tcaggcaaat tggggagggg agggtgtatc tagctctagt tcaaattatt   2280

tggaagtgtt ccctgagaaa cccaccagcc taagaagctc tggccccagg cttgtcacta   2340

gcagctgcag tcaacagttc aaagaagtca tggcccaaat ccagtgtgca cccctcccca   2400

ttcacagagc ctttttcaca attccatttc cagttcatct atggcagtcc agccagctcc   2460

tgggcagctt gagagggcaa acccaaaacc tcatgacagc cagagcctgt ctttcagcat   2520

tcagtccgcc tggccggctc cagtttcccc atggggctgc gggacagagg accattacaa   2580

ctagatcaag gagcccagaa aacctccagt agtggacaac aggttttcac catagcctac   2640

gttaacccat ttttgagcca agcttcaacc ctcagccttg aaaaacaagt ctttaattta   2700

atttttgttt tttgcctaaa tccaaagaaa aagggctgcc gggccaggcg cggtggctca   2760

cgcctgtaat cccagcactt tggcaggccg aggcaggtgg atcacctgac gtcagtagtt   2820

tgagaccagc ctggccaaca tggtgaaacc ctgtatctac taaaaataca aaaattagcc   2880

ggacgtggtg gtgcgcgcat gtaatcccag ctactcggga ggctgaggcg gaagaatcac   2940

ttgaacccgg gaggcggagg ttccagtgag ccgagatggc gctattgcac tccagtctgg   3000

gtaacaggga gactgcatct caaaaaaaaa aaaaaaaaaa aaaaagggct gtccatgtat   3060

tcacacaccc ctcaaaaaaa gcctttagtt cctactttag ccactggttt ctcagaatcc   3120

aaagatcaca tattctagtg taacactgca agaagtcttg agaaaaagat tattgtagtg   3180

ttcaaaatat ttttgtattg ttaatgcatc atcatagaaa aacttttaaa catgagaata   3240

aagatacttt ttactgggtt tgtttttcaa agcctg                             3276


<210>  2807
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  2807

Met Pro Gln Leu Asp Ser Gly Gly Gly Gly Ala Gly Gly Gly Asp Asp 
1               5                   10                  15


Leu Gly Ala Pro Asp Glu Leu Leu Ala Phe Gln Asp Glu Gly Glu Glu 
            20                  25                  30


Gln Asp Asp Lys Ser Arg Asp Ser Ala Ala Gly Pro Glu Arg Asp Leu 
        35                  40                  45


Ala Glu Leu Lys Ser Ser Leu Val Asn Glu Ser Glu Gly Ala Ala Gly 
    50                  55                  60


Gly Ala Gly Ile Pro Gly Val Pro Gly Ala Gly Ala Gly Ala Arg Gly 
65                  70                  75                  80


Glu Ala Glu Ala Leu Gly Arg Glu His Ala Ala Gln Arg Leu Phe Pro 
                85                  90                  95


Asp Lys Leu Pro Glu Pro Leu Glu Asp Gly Leu Lys Ala Pro Glu Cys 
            100                 105                 110


Thr Ser Gly Met Tyr Lys Glu Thr Val Tyr Ser Ala Phe Asn Leu Leu 
        115                 120                 125


Met His Tyr Pro Pro Pro Ser Gly Ala Gly Gln His Pro Gln Pro Gln 
    130                 135                 140


Pro Pro Leu His Lys Ala Asn Gln Pro Pro His Gly Val Pro Gln Leu 
145                 150                 155                 160


Ser Leu Tyr Glu His Phe Asn Ser Pro His Pro Thr Pro Ala Pro Ala 
                165                 170                 175


Asp Ile Ser Gln Lys Gln Val His Arg Pro Leu Gln Thr Pro Asp Leu 
            180                 185                 190


Ser Gly Phe Tyr Ser Leu Thr Ser Gly Ser Met Gly Gln Leu Pro His 
        195                 200                 205


Thr Val Ser Trp Phe Thr His Pro Ser Leu Met Leu Gly Ser Gly Val 
    210                 215                 220


Pro Gly His Pro Ala Ala Ile Pro His Pro Ala Ile Val Pro Pro Ser 
225                 230                 235                 240


Gly Lys Gln Glu Leu Gln Pro Phe Asp Arg Asn Leu Lys Thr Gln Ala 
                245                 250                 255


Glu Ser Lys Ala Glu Lys Glu Ala Lys Lys Pro Thr Ile Lys Lys Pro 
            260                 265                 270


Leu Asn Ala Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val Ile 
        275                 280                 285


Ala Glu Cys Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly 
    290                 295                 300


Arg Arg Trp His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu 
305                 310                 315                 320


Leu Ala Arg Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly Trp 
                325                 330                 335


Ser Ala Arg Asp Asn Tyr Gly Lys Lys Lys Arg Arg Ser Arg Glu Lys 
            340                 345                 350


His Gln Glu Ser Thr Thr Gly Gly Lys Arg Asn Ala Phe Gly Thr Tyr 
        355                 360                 365


Pro Glu Lys Ala Ala Ala Pro Ala Pro Phe Leu Pro Met Thr Val Leu 
    370                 375                 380


<210>  2808
<211>  628
<212>  DNA
<213>  Homo sapiens

<400>  2808
cgcggagccg ctctgccccg cgccctagcc cgcgcctgca gcccgcccag gcggagtcag     60

cccgcgctcc gcccgccgcg atccgagctc ggaggttcgg actccgggct cgccgccccc    120

cgggccggct ccgcgccccg cactcccggc gcccagcgcc ccgcgccccg gcgggcggag    180

cgcaccatgc cgcagctgga ctccggcggg ggcggcgcgg gcggcggcga cgacctcggc    240

gcgccggacg agctgctggc cttccaggat gaaggcgagg agcaggacga caagagccgc    300

gacagcgccg ccggtcccga gcgcgacctg gccgagctca agtcgtcgct cgtgaacgag    360

tccgagggcg cggccggcgg cgcagggatc ccgggggtcc cgggggccgg cgccggggcc    420

cgcggcgagg ccgaggctct cgggcgggaa cacgctgcgc agagactctt cccggacaaa    480

cttccagagc ccctggagga cggcctgaag gccccggagt gcaccagcgg catgtacaaa    540

gagaccgtct actccgcctt caatctgctc atgcattacc cacccccctc gggagcaggg    600

cagcaccccc agccgcagcc cccgctgg                                       628


<210>  2809
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  2809

Met Pro Gln Leu Asp Ser Gly Gly Gly Gly Ala Gly Gly Gly Asp Asp 
1               5                   10                  15


Leu Gly Ala Pro Asp Glu Leu Leu Ala Phe Gln Asp Glu Gly Glu Glu 
            20                  25                  30


Gln Asp Asp Lys Ser Arg Asp Ser Ala Ala Gly Pro Glu Arg Asp Leu 
        35                  40                  45


Ala Glu Leu Lys Ser Ser Leu Val Asn Glu Ser Glu Gly Ala Ala Gly 
    50                  55                  60


Gly Ala Gly Ile Pro Gly Val Pro Gly Ala Gly Ala Gly Ala Arg Gly 
65                  70                  75                  80


Glu Ala Glu Ala Leu Gly Arg Glu His Ala Ala Gln Arg Leu Phe Pro 
                85                  90                  95


Asp Lys Leu Pro Glu Pro Leu Glu Asp Gly Leu Lys Ala Pro Glu Cys 
            100                 105                 110


Thr Ser Gly Met Tyr Lys Glu Thr Val Tyr Ser Ala Phe Asn Leu Leu 
        115                 120                 125


Met His Tyr Pro Pro Pro Ser Gly Ala Gly Gln His Pro Gln Pro Gln 
    130                 135                 140


Pro Pro 
145


<210>  2810
<211>  221
<212>  DNA
<213>  Homo sapiens

<400>  2810
gcgccctagc ccgcgcctgc agcccgccca ggcggacgca ccatgccgca gctggactcc     60

ggcgggggcg gcgcgggcgg cggcgacgac ctcggcgcgc cggacgagct gctggccttc    120

caggatgaag gcgaggagca ggacgacaag agccgcgaca gcgccgccgg tcccgagcgc    180

gacctggccg agctcaagtc gtcgctcgtg aacgagtccg a                        221


<210>  2811
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  2811

Met Pro Gln Leu Asp Ser Gly Gly Gly Gly Ala Gly Gly Gly Asp Asp 
1               5                   10                  15


Leu Gly Ala Pro Asp Glu Leu Leu Ala Phe Gln Asp Glu Gly Glu Glu 
            20                  25                  30


Gln Asp Asp Lys Ser Arg Asp Ser Ala Ala Gly Pro Glu Arg Asp Leu 
        35                  40                  45


Ala Glu Leu Lys Ser Ser Leu Val Asn Glu 
    50                  55


<210>  2812
<211>  280
<212>  DNA
<213>  Homo sapiens

<400>  2812
acgagctgct ggccttccag gatgaaggcg aggagcagga cgacaagagc cgcgacagcg     60

ccgccggtcc cgagcgcgac ctggctctcg ggcgggaaca cgctgcgcag agactcttcc    120

cggacaaact tccagagccc ctggaggacg gcctgaaggc cccggagtgc accagcggca    180

tgtacaaaga gaccgtctac tccgccttca atctgctcat gcattaccca cccccctcgg    240

gagcagggca gcacccccag ccgcagcccc cgctggtaag                          280


<210>  2813
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  2813

Met Lys Ala Arg Ser Arg Thr Thr Arg Ala Ala Thr Ala Pro Pro Val 
1               5                   10                  15


Pro Ser Ala Thr Trp Leu Ser Gly Gly Asn Thr Leu Arg Arg Asp Ser 
            20                  25                  30


Ser Arg Thr Asn Phe Gln Ser Pro Trp Arg Thr Ala 
        35                  40


<210>  2814
<211>  3297
<212>  DNA
<213>  Homo sapiens

<400>  2814
atccccgcct cccctcctgc ccaggtgact gactaatccg ccgccttcag gagacagaat     60

tggccaaggc ctgaaggccc cggagtgcac cagcggcatg tacaaagaga ccgtctactc    120

cgccttcaat ctgctcatgc attacccacc cccctcggga gcagggcagc acccccagcc    180

gcagcccccg ctgcacaagg ccaatcagcc cccccacggt gtcccccaac tctctctcta    240

cgaacatttc aacagcccac atcccacccc tgcacctgcg gacatcagcc agaagcaagt    300

tcacaggcct ctgcagaccc ctgacctctc tggcttctac tccctgacct caggcagcat    360

ggggcagctc ccccacactg tgagctggtt cacccaccca tccttgatgc taggttctgg    420

tgtacctggt cacccagcag ccatccccca cccggccatt gtgcccccct cagggaagca    480

ggagctgcag cccttcgacc gcaacctgaa gacacaagca gagtccaagg cagagaagga    540

ggccaagaag ccaaccatca agaagcccct caatgccttc atgctgtaca tgaaggagat    600

gagagccaag gtcattgcag agtgcacact taaggagagc gctgccatca accagatcct    660

gggccgcagg tggcacgcgc tgtcgcgaga agagcaggcc aagtactatg agctggcccg    720

caaggagagg cagctgcaca tgcagctata cccaggctgg tcagcgcggg acaactacgg    780

gaagaagaag aggcggtcga gggaaaagca ccaagaatcc accacagaga caaactggcc    840

cagagaactc aaggatggta atggacaaga gtcactgtcc atgtcttctt cctctagccc    900

agcttgagga ctgggatggc tgggcaagga agccataggc attgcggccc cttgccttgg    960

tgcagatgtg agtcccacaa acacatctgg agaagctcaa aggccgggac tgggagatga   1020

ctcccttgga agacaggaga gatgactccc ttggaagaca gatgacagcc cataggccta   1080

gtgacaaaag gcccctttgc caccttgtgg ctgttctggg aactgcacct gtcctaggtc   1140

tgggccagac caagcagaat ggcagtctga ggacactgac ttaccaccca agtcccagga   1200

agagaggaca aggaatcagc caggcctgtg caaaggcagc attttttggt tgtggtgtat   1260

gactatgaat tcaccctctg tttacagata actctcttca ctattcctag gaggaaaaag   1320

aaatgcattc ggtacttacc cggagaaggc cgctgcccca gccccgttcc ttccgatgac   1380

agtgctctag gctgccccgg gtccccagct ccccaggact caccctcata ccatctgctg   1440

ccccgcttcc ccacagaact gcttactagc cctgcggagc cggcacctac atccccaggt   1500

ctctccactg ctctcagcct cccaacccca gggcccccac aggccccccg cagcaccctg   1560

cagagcacac aggtacagca acaggaatct cagagacagg tggcctagca ggcacaggac   1620

acctggccgc ctccaggagc ctaccccctg aaagtgacag agacccagat ctcatggaaa   1680

ctggccaggg gtcctgttaa cgtcatctca gggtccagac cctgaagatt tcagaggctg   1740

caggacttct gcctgaacct ggggtcatcg attcaaactg ctccaagtgg tgggaatcag   1800

atctgtcttg atgtgtcatc taattaaggg aatcccttgt acctatggct gcctgcatct   1860

attctttgta ccatctgtct tgccagccag aagcctctgc ctccctagct tttctgctat   1920

aggtcagaga tgggctgaac tgagcctagc taccttctct acccatctcc cccatccccc   1980

actgccacac cctccccatt cagacacttc atggaccaag aatgagctgg tttgtcaaac   2040

aacatgtgag catggtcaca agcacaaagc tcaagatgac agctcttcta aggaaatgga   2100

gaagctctgt ttataaaaac aaaaacaaaa ccagctgcta ctcataagtt ggaccagagg   2160

aagcccctta ctatgatctc aggagcttgc aagaagcagg aaggggaatg gaataggtta   2220

agtttaggcc tatcaaccta agcaacagaa ataatctgac actaccttat caggcaaatt   2280

ggggagggga gggtgtatct agctctagtt caaattattt ggaagtgttc cctgagaaac   2340

ccaccagcct aagaagctct ggccccaggc ttgtcactag cagctgcagt caacagttca   2400

aagaagtcat ggcccaaatc cagtgtgcac ccctccccat tcacagagcc tttttcacaa   2460

ttccatttcc agttcatcta tggcagtcca gccagctcct gggcagcttg agagggcaaa   2520

cccaaaacct catgacagcc agagcctgtc tttcagcatt cagtccgcct ggccggctcc   2580

agtttcccca tggggctgcg ggacagagga ccattacaac tagatcaagg agcccagaaa   2640

acctccagta gtggacaaca ggttttcacc atagcctacg ttaacccatt tttgagccaa   2700

gcttcaaccc tcagccttga aaaacaagtc tttaatttaa tttttgtttt ttgcctaaat   2760

ccaaagaaaa agggctgccg ggccaggcgc ggtggctcac gcctgtaatc ccagcacttt   2820

ggcaggccga ggcaggtgga tcacctgacg tcagtagttt gagaccagcc tggccaacat   2880

ggtgaaaccc tgtatctact aaaaatacaa aaattagccg gacgtggtgg tgcgcgcatg   2940

taatcccagc tactcgggag gctgaggcgg aagaatcact tgaacccggg aggcggaggt   3000

tccagtgagc cgagatggcg ctattgcact ccagtctggg taacagggag actgcatctc   3060

aaaaaaaaaa aaaaaaaaaa aaaagggctg tccatgtatt cacacacccc tcaaaaaaag   3120

cctttagttc ctactttagc cactggtttc tcagaatcca aagatcacat attctagtgt   3180

aacactgcaa gaagtcttga gaaaaagatt attgtagtgt tcaaaatatt tttgtattgt   3240

taatgcatca tcatagaaaa acttttaaac atgagaataa agatactttt tactggg      3297


<210>  2815
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  2815

Met Tyr Lys Glu Thr Val Tyr Ser Ala Phe Asn Leu Leu Met His Tyr 
1               5                   10                  15


Pro Pro Pro Ser Gly Ala Gly Gln His Pro Gln Pro Gln Pro Pro Leu 
            20                  25                  30


His Lys Ala Asn Gln Pro Pro His Gly Val Pro Gln Leu Ser Leu Tyr 
        35                  40                  45


Glu His Phe Asn Ser Pro His Pro Thr Pro Ala Pro Ala Asp Ile Ser 
    50                  55                  60


Gln Lys Gln Val His Arg Pro Leu Gln Thr Pro Asp Leu Ser Gly Phe 
65                  70                  75                  80


Tyr Ser Leu Thr Ser Gly Ser Met Gly Gln Leu Pro His Thr Val Ser 
                85                  90                  95


Trp Phe Thr His Pro Ser Leu Met Leu Gly Ser Gly Val Pro Gly His 
            100                 105                 110


Pro Ala Ala Ile Pro His Pro Ala Ile Val Pro Pro Ser Gly Lys Gln 
        115                 120                 125


Glu Leu Gln Pro Phe Asp Arg Asn Leu Lys Thr Gln Ala Glu Ser Lys 
    130                 135                 140


Ala Glu Lys Glu Ala Lys Lys Pro Thr Ile Lys Lys Pro Leu Asn Ala 
145                 150                 155                 160


Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val Ile Ala Glu Cys 
                165                 170                 175


Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly Arg Arg Trp 
            180                 185                 190


His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu Leu Ala Arg 
        195                 200                 205


Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly Trp Ser Ala Arg 
    210                 215                 220


Asp Asn Tyr Gly Lys Lys Lys Arg Arg Ser Arg Glu Lys His Gln Glu 
225                 230                 235                 240


Ser Thr Thr Glu Thr Asn Trp Pro Arg Glu Leu Lys Asp Gly Asn Gly 
                245                 250                 255


Gln Glu Ser Leu Ser Met Ser Ser Ser Ser Ser Pro Ala 
            260                 265


<210>  2816
<211>  2905
<212>  DNA
<213>  Homo sapiens

<400>  2816
atccccgcct cccctcctgc ccaggtgact gactaatccg ccgccttcag gagacagaat     60

tggccaaggc ctgaaggccc cggagtgcac cagcggcatg tacaaagaga ccgtctactc    120

cgccttcaat ctgctcatgc attacccacc cccctcggga gcagggcagc acccccagcc    180

gcagcccccg ctgcacaagg ccaatcagcc cccccacggt gtcccccaac tctctctcta    240

cgaacatttc aacagcccac atcccacccc tgcacctgcg gacatcagcc agaagcaagt    300

tcacaggcct ctgcagaccc ctgacctctc tggcttctac tccctgacct caggcagcat    360

ggggcagctc ccccacactg tgagctggtt cacccaccca tccttgatgc taggttctgg    420

tgtacctggt cacccagcag ccatccccca cccggccatt gtgcccccct cagggaagca    480

ggagctgcag cccttcgacc gcaacctgaa gacacaagca gagtccaagg cagagaagga    540

ggccaagaag ccaaccatca agaagcccct caatgccttc atgctgtaca tgaaggagat    600

gagagccaag gtcattgcag agtgcacact taaggagagc gctgccatca accagatcct    660

gggccgcagg tggcacgcgc tgtcgcgaga agagcaggcc aagtactatg agctggcccg    720

caaggagagg cagctgcaca tgcagctata cccaggctgg tcagcgcggg acaactacgg    780

gaagaagaag aggcggtcga gggaaaagca ccaagaatcc accacagacc ctggctcgcc    840

taagaaatgc cgtgctcgct ttggcctcaa ccagcagacg gattggtgtg gtccgtgcag    900

gaggaaaaag aaatgcattc ggtacttacc cggagaaggc cgctgcccca gccccgttcc    960

ttccgatgac agtgctctag gctgccccgg gtccccagct ccccaggact caccctcata   1020

ccatctgctg ccccgcttcc ccacagaact gcttactagc cctgcggagc cggcacctac   1080

atccccaggt ctctccactg ctctcagcct cccaacccca gggcccccac aggccccccg   1140

cagcaccctg cagagcacac aggtacagca acaggaatct cagagacagg tggcctagca   1200

ggcacaggac acctggccgc ctccaggagc ctaccccctg aaagtgacag agacccagat   1260

ctcatggaaa ctggccaggg gtcctgttaa cgtcatctca gggtccagac cctgaagatt   1320

tcagaggctg caggacttct gcctgaacct ggggtcatcg attcaaactg ctccaagtgg   1380

tgggaatcag atctgtcttg atgtgtcatc taattaaggg aatcccttgt acctatggct   1440

gcctgcatct attctttgta ccatctgtct tgccagccag aagcctctgc ctccctagct   1500

tttctgctat aggtcagaga tgggctgaac tgagcctagc taccttctct acccatctcc   1560

cccatccccc actgccacac cctccccatt cagacacttc atggaccaag aatgagctgg   1620

tttgtcaaac aacatgtgag catggtcaca agcacaaagc tcaagatgac agctcttcta   1680

aggaaatgga gaagctctgt ttataaaaac aaaaacaaaa ccagctgcta ctcataagtt   1740

ggaccagagg aagcccctta ctatgatctc aggagcttgc aagaagcagg aaggggaatg   1800

gaataggtta agtttaggcc tatcaaccta agcaacagaa ataatctgac actaccttat   1860

caggcaaatt ggggagggga gggtgtatct agctctagtt caaattattt ggaagtgttc   1920

cctgagaaac ccaccagcct aagaagctct ggccccaggc ttgtcactag cagctgcagt   1980

caacagttca aagaagtcat ggcccaaatc cagtgtgcac ccctccccat tcacagagcc   2040

tttttcacaa ttccatttcc agttcatcta tggcagtcca gccagctcct gggcagcttg   2100

agagggcaaa cccaaaacct catgacagcc agagcctgtc tttcagcatt cagtccgcct   2160

ggccggctcc agtttcccca tggggctgcg ggacagagga ccattacaac tagatcaagg   2220

agcccagaaa acctccagta gtggacaaca ggttttcacc atagcctacg ttaacccatt   2280

tttgagccaa gcttcaaccc tcagccttga aaaacaagtc tttaatttaa tttttgtttt   2340

ttgcctaaat ccaaagaaaa agggctgccg ggccaggcgc ggtggctcac gcctgtaatc   2400

ccagcacttt ggcaggccga ggcaggtgga tcacctgacg tcagtagttt gagaccagcc   2460

tggccaacat ggtgaaaccc tgtatctact aaaaatacaa aaattagccg gacgtggtgg   2520

tgcgcgcatg taatcccagc tactcgggag gctgaggcgg aagaatcact tgaacccggg   2580

aggcggaggt tccagtgagc cgagatggcg ctattgcact ccagtctggg taacagggag   2640

actgcatctc aaaaaaaaaa aaaaaaaaaa aaaagggctg tccatgtatt cacacacccc   2700

tcaaaaaaag cctttagttc ctactttagc cactggtttc tcagaatcca aagatcacat   2760

attctagtgt aacactgcaa gaagtcttga gaaaaagatt attgtagtgt tcaaaatatt   2820

tttgtattgt taatgcatca tcatagaaaa acttttaaac atgagaataa agatactttt   2880

tactgggttt gtttttcaaa gcctg                                         2905


<210>  2817
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  2817

Met Tyr Lys Glu Thr Val Tyr Ser Ala Phe Asn Leu Leu Met His Tyr 
1               5                   10                  15


Pro Pro Pro Ser Gly Ala Gly Gln His Pro Gln Pro Gln Pro Pro Leu 
            20                  25                  30


His Lys Ala Asn Gln Pro Pro His Gly Val Pro Gln Leu Ser Leu Tyr 
        35                  40                  45


Glu His Phe Asn Ser Pro His Pro Thr Pro Ala Pro Ala Asp Ile Ser 
    50                  55                  60


Gln Lys Gln Val His Arg Pro Leu Gln Thr Pro Asp Leu Ser Gly Phe 
65                  70                  75                  80


Tyr Ser Leu Thr Ser Gly Ser Met Gly Gln Leu Pro His Thr Val Ser 
                85                  90                  95


Trp Phe Thr His Pro Ser Leu Met Leu Gly Ser Gly Val Pro Gly His 
            100                 105                 110


Pro Ala Ala Ile Pro His Pro Ala Ile Val Pro Pro Ser Gly Lys Gln 
        115                 120                 125


Glu Leu Gln Pro Phe Asp Arg Asn Leu Lys Thr Gln Ala Glu Ser Lys 
    130                 135                 140


Ala Glu Lys Glu Ala Lys Lys Pro Thr Ile Lys Lys Pro Leu Asn Ala 
145                 150                 155                 160


Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val Ile Ala Glu Cys 
                165                 170                 175


Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly Arg Arg Trp 
            180                 185                 190


His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu Leu Ala Arg 
        195                 200                 205


Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly Trp Ser Ala Arg 
    210                 215                 220


Asp Asn Tyr Gly Lys Lys Lys Arg Arg Ser Arg Glu Lys His Gln Glu 
225                 230                 235                 240


Ser Thr Thr Asp Pro Gly Ser Pro Lys Lys Cys Arg Ala Arg Phe Gly 
                245                 250                 255


Leu Asn Gln Gln Thr Asp Trp Cys Gly Pro Cys Arg Arg Lys Lys Lys 
            260                 265                 270


Cys Ile Arg Tyr Leu Pro Gly Glu Gly Arg Cys Pro Ser Pro Val Pro 
        275                 280                 285


Ser Asp Asp Ser Ala Leu Gly Cys Pro Gly Ser Pro Ala Pro Gln Asp 
    290                 295                 300


Ser Pro Ser Tyr His Leu Leu Pro Arg Phe Pro Thr Glu Leu Leu Thr 
305                 310                 315                 320


Ser Pro Ala Glu Pro Ala Pro Thr Ser Pro Gly Leu Ser Thr Ala Leu 
                325                 330                 335


Ser Leu Pro Thr Pro Gly Pro Pro Gln Ala Pro Arg Ser Thr Leu Gln 
            340                 345                 350


Ser Thr Gln Val Gln Gln Gln Glu Ser Gln Arg Gln Val Ala 
        355                 360                 365


<210>  2818
<211>  2832
<212>  DNA
<213>  Homo sapiens

<400>  2818
atccccgcct cccctcctgc ccaggtgact gactaatccg ccgccttcag gagacagaat     60

tggccaaggc ctgaaggccc cggagtgcac cagcggcatg tacaaagaga ccgtctactc    120

cgccttcaat ctgctcatgc attacccacc cccctcggga gcagggcagc acccccagcc    180

gcagcccccg ctgcacaagg ccaatcagcc cccccacggt gtcccccaac tctctctcta    240

cgaacatttc aacagcccac atcccacccc tgcacctgcg gacatcagcc agaagcaagt    300

tcacaggcct ctgcagaccc ctgacctctc tggcttctac tccctgacct caggcagcat    360

ggggcagctc ccccacactg tgagctggtt cacccaccca tccttgatgc taggttctgg    420

tgtacctggt cacccagcag ccatccccca cccggccatt gtgcccccct cagggaagca    480

ggagctgcag cccttcgacc gcaacctgaa gacacaagca gagtccaagg cagagaagga    540

ggccaagaag ccaaccatca agaagcccct caatgccttc atgctgtaca tgaaggagat    600

gagagccaag gtcattgcag agtgcacact taaggagagc gctgccatca accagatcct    660

gggccgcagg tggcacgcgc tgtcgcgaga agagcaggcc aagtactatg agctggcccg    720

caaggagagg cagctgcaca tgcagctata cccaggctgg tcagcgcggg acaactacgg    780

gaagaagaag aggcggtcga gggaaaagca ccaagaatcc accacaggag gaaaaagaaa    840

tgcattcggt acttacccgg agaaggccgc tgccccagcc ccgttccttc cgatgacagt    900

gctctaggct gccccgggtc cccagctccc caggactcac cctcatacca tctgctgccc    960

cgcttcccca cagaactgct tactagccct gcggagccgg cacctacatc cccaggtctc   1020

tccactgctc tcagcctccc aaccccaggg cccccacagg ccccccgcag caccctgcag   1080

agcacacagg tacagcaaca ggaatctcag agacaggtgg cctagcaggc acaggacacc   1140

tggccgcctc caggagccta ccccctgaaa gtgacagaga cccagatctc atggaaactg   1200

gccaggggtc ctgttaacgt catctcaggg tccagaccct gaagatttca gaggctgcag   1260

gacttctgcc tgaacctggg gtcatcgatt caaactgctc caagtggtgg gaatcagatc   1320

tgtcttgatg tgtcatctaa ttaagggaat cccttgtacc tatggctgcc tgcatctatt   1380

ctttgtacca tctgtcttgc cagccagaag cctctgcctc cctagctttt ctgctatagg   1440

tcagagatgg gctgaactga gcctagctac cttctctacc catctccccc atcccccact   1500

gccacaccct ccccattcag acacttcatg gaccaagaat gagctggttt gtcaaacaac   1560

atgtgagcat ggtcacaagc acaaagctca agatgacagc tcttctaagg aaatggagaa   1620

gctctgttta taaaaacaaa aacaaaacca gctgctactc ataagttgga ccagaggaag   1680

ccccttacta tgatctcagg agcttgcaag aagcaggaag gggaatggaa taggttaagt   1740

ttaggcctat caacctaagc aacagaaata atctgacact accttatcag gcaaattggg   1800

gaggggaggg tgtatctagc tctagttcaa attatttgga agtgttccct gagaaaccca   1860

ccagcctaag aagctctggc cccaggcttg tcactagcag ctgcagtcaa cagttcaaag   1920

aagtcatggc ccaaatccag tgtgcacccc tccccattca cagagccttt ttcacaattc   1980

catttccagt tcatctatgg cagtccagcc agctcctggg cagcttgaga gggcaaaccc   2040

aaaacctcat gacagccaga gcctgtcttt cagcattcag tccgcctggc cggctccagt   2100

ttccccatgg ggctgcggga cagaggacca ttacaactag atcaaggagc ccagaaaacc   2160

tccagtagtg gacaacaggt tttcaccata gcctacgtta acccattttt gagccaagct   2220

tcaaccctca gccttgaaaa acaagtcttt aatttaattt ttgttttttg cctaaatcca   2280

aagaaaaagg gctgccgggc caggcgcggt ggctcacgcc tgtaatccca gcactttggc   2340

aggccgaggc aggtggatca cctgacgtca gtagtttgag accagcctgg ccaacatggt   2400

gaaaccctgt atctactaaa aatacaaaaa ttagccggac gtggtggtgc gcgcatgtaa   2460

tcccagctac tcgggaggct gaggcggaag aatcacttga acccgggagg cggaggttcc   2520

agtgagccga gatggcgcta ttgcactcca gtctgggtaa cagggagact gcatctcaaa   2580

aaaaaaaaaa aaaaaaaaaa agggctgtcc atgtattcac acacccctca aaaaaagcct   2640

ttagttccta ctttagccac tggtttctca gaatccaaag atcacatatt ctagtgtaac   2700

actgcaagaa gtcttgagaa aaagattatt gtagtgttca aaatattttt gtattgttaa   2760

tgcatcatca tagaaaaact tttaaacatg agaataaaga tactttttac tgggtttgtt   2820

tttcaaagcc tg                                                       2832


<210>  2819
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  2819

Met Tyr Lys Glu Thr Val Tyr Ser Ala Phe Asn Leu Leu Met His Tyr 
1               5                   10                  15


Pro Pro Pro Ser Gly Ala Gly Gln His Pro Gln Pro Gln Pro Pro Leu 
            20                  25                  30


His Lys Ala Asn Gln Pro Pro His Gly Val Pro Gln Leu Ser Leu Tyr 
        35                  40                  45


Glu His Phe Asn Ser Pro His Pro Thr Pro Ala Pro Ala Asp Ile Ser 
    50                  55                  60


Gln Lys Gln Val His Arg Pro Leu Gln Thr Pro Asp Leu Ser Gly Phe 
65                  70                  75                  80


Tyr Ser Leu Thr Ser Gly Ser Met Gly Gln Leu Pro His Thr Val Ser 
                85                  90                  95


Trp Phe Thr His Pro Ser Leu Met Leu Gly Ser Gly Val Pro Gly His 
            100                 105                 110


Pro Ala Ala Ile Pro His Pro Ala Ile Val Pro Pro Ser Gly Lys Gln 
        115                 120                 125


Glu Leu Gln Pro Phe Asp Arg Asn Leu Lys Thr Gln Ala Glu Ser Lys 
    130                 135                 140


Ala Glu Lys Glu Ala Lys Lys Pro Thr Ile Lys Lys Pro Leu Asn Ala 
145                 150                 155                 160


Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val Ile Ala Glu Cys 
                165                 170                 175


Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly Arg Arg Trp 
            180                 185                 190


His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu Leu Ala Arg 
        195                 200                 205


Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly Trp Ser Ala Arg 
    210                 215                 220


Asp Asn Tyr Gly Lys Lys Lys Arg Arg Ser Arg Glu Lys His Gln Glu 
225                 230                 235                 240


Ser Thr Thr Gly Gly Lys Arg Asn Ala Phe Gly Thr Tyr Pro Glu Lys 
                245                 250                 255


Ala Ala Ala Pro Ala Pro Phe Leu Pro Met Thr Val Leu 
            260                 265


<210>  2820
<211>  530
<212>  DNA
<213>  Homo sapiens

<400>  2820
cccgcctccc ctcctgccca ggtgactgac taatccgccg ccttcaggag acagaattgg     60

ccaaggtttc ttggttggag ggcggggggt gggaggtcaa gtaggggcca cctcggggag    120

gcctgccctc caggtccttc ccctaaaact tggcactgcc gatactccca gcccgttcct    180

tcccaagtca ggaacttgca ggggacccct tggcaattct ttttctctca agagcagaca    240

gccttcagtc ccagccgctg ccagggctgg tgtgtctgac ccagctgtgg tttttccagg    300

cctgaaggcc ccggagtgca ccagcggcat gtacaaagag accgtctact ccgccttcaa    360

tctgctcatg cattacccac ccccctcggg agcagggcag cacccccagc cgcagccccc    420

gctgcacaag gccaatcagc ccccccacgg tgtcccccaa ctctctctct acgaacattt    480

caacagccca catcccaccc ctgcacctgc ggacatcagc cagaagcaag               530


<210>  2821
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  2821

Met Tyr Lys Glu Thr Val Tyr Ser Ala Phe Asn Leu Leu Met His Tyr 
1               5                   10                  15


Pro Pro Pro Ser Gly Ala Gly Gln His Pro Gln Pro Gln Pro Pro Leu 
            20                  25                  30


His Lys Ala Asn Gln Pro Pro His Gly Val Pro Gln Leu Ser Leu Tyr 
        35                  40                  45


Glu His Phe Asn Ser Pro His Pro Thr Pro Ala Pro Ala Asp Ile Ser 
    50                  55                  60


Gln Lys 
65


<210>  2822
<211>  734
<212>  DNA
<213>  Homo sapiens

<400>  2822
cccgcctccc ctcctgccca ggtgactgac taatccgccg ccttcaggag acagaattgg     60

ccaaggtttc ttggttggag ggcggggggt gggaggtcaa gtaggggcca cctcggggag    120

gcctgccctc caggtccttc ccctaaaact tggcactgcc gatactccca gcccgttcct    180

tcccaagtca ggaacttgca ggggacccct tggcaattct ttttctctca agagcagaca    240

gccttcagtc ccagccgctg ccagggctgg tgtgtctgac ccagctgtgg tttttccagg    300

cctgaaggcc ccggagtgca ccagcggcat gtacaaagag accgtctact ccgccttcaa    360

tctgctcatg cattacccac ccccctcggg agcagggcag cacccccagc cgcagccccc    420

gctgcacaag gccaatcagc ccccccacgg tgtcccccaa ctctctctct acgaacattt    480

caacagccca catcccaccc ctgcacctgc ggacatcagc cagaagcaag ttcacaggcc    540

tctgcagacc cctgacctct ctggcttcta ctccctgacc tcaggcagca tggggcagct    600

cccccacact gtgagctggc ccagccctcc tctctacccc ctgtcccccc cctgctgtcc    660

tgtgcctgag aatgaagcta gtgcaagtgc caagaggcct cagcctgggc cacaccgtgc    720

agcagagcac caca                                                      734


<210>  2823
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  2823

Met Tyr Lys Glu Thr Val Tyr Ser Ala Phe Asn Leu Leu Met His Tyr 
1               5                   10                  15


Pro Pro Pro Ser Gly Ala Gly Gln His Pro Gln Pro Gln Pro Pro Leu 
            20                  25                  30


His Lys Ala Asn Gln Pro Pro His Gly Val Pro Gln Leu Ser Leu Tyr 
        35                  40                  45


Glu His Phe Asn Ser Pro His Pro Thr Pro Ala Pro Ala Asp Ile Ser 
    50                  55                  60


Gln Lys Gln Val His Arg Pro Leu Gln Thr Pro Asp Leu Ser Gly Phe 
65                  70                  75                  80


Tyr Ser Leu Thr Ser Gly Ser Met Gly Gln Leu Pro His Thr Val Ser 
                85                  90                  95


Trp Pro Ser Pro Pro Leu Tyr Pro Leu Ser Pro Pro Cys Cys Pro Val 
            100                 105                 110


Pro Glu Asn Glu Ala Ser Ala Ser Ala Lys Arg Pro Gln Pro Gly Pro 
        115                 120                 125


His Arg Ala Ala Glu His 
    130


<210>  2824
<211>  3063
<212>  DNA
<213>  Homo sapiens

<400>  2824
cccgcctccc ctcctgccca ggtgactgac taatccgccg ccttcaggag acagaattgg     60

ccaaggtttc ttggttggag ggcggggggt gggaggtcaa gtaggggcca cctcggggag    120

gcctgccctc caggtccttc ccctaaaact tggcactgcc gatactccca gcccgttcct    180

tcccaagtca ggaacttgca ggggacccct tggcaattct ttttctctca agagcagaca    240

gccttcagtc ccagccgctg ccagggctgg tgtgtctgac ccagctgtgg tttttccagg    300

cctgaaggcc ccggagtgca ccagcggcat gtacaaagag accgtctact ccgccttcaa    360

tctgctcatg cattacccac ccccctcggg agcagggcag cacccccagc cgcagccccc    420

gctgcacaag gccaatcagc ccccccacgg tgtcccccaa ctctctctct acgaacattt    480

caacagccca catcccaccc ctgcacctgc ggacatcagc cagaagcaag ttcacaggcc    540

tctgcagacc cctgacctct ctggcttcta ctccctgacc tcaggcagca tggggcagct    600

cccccacact gtgagctggt tcacccaccc atccttgatg ctaggttctg gtgtacctgg    660

tcacccagca gccatccccc acccggccat tgtgcccccc tcagggaagc aggagctgca    720

gcccttcgac cgcaacctga agacacaagc agagtccaag gcagagaagg aggccaagaa    780

gccaaccatc aagaagcccc tcaatgcctt catgctgtac atgaaggaga tgagagccaa    840

ggtcattgca gagtgcacac ttaaggagag cgctgccatc aaccagatcc tgggccgcag    900

gtggcacgcg ctgtcgcgag aagagcaggc caagtactat gagctggccc gcaaggagag    960

gcagctgcac atgcagctat acccaggctg gtcagcgcgg gacaactacg ggaagaagaa   1020

gaggcggtcg agggaaaagc accaagaatc caccacagga ggaaaaagaa atgcattcgg   1080

tacttacccg gagaaggccg ctgccccagc cccgttcctt ccgatgacag tgctctaggc   1140

tgccccgggt ccccagctcc ccaggactca ccctcatacc atctgctgcc ccgcttcccc   1200

acagaactgc ttactagccc tgcggagccg gcacctacat ccccaggtct ctccactgct   1260

ctcagcctcc caaccccagg gcccccacag gccccccgca gcaccctgca gagcacacag   1320

gtacagcaac aggaatctca gagacaggtg gcctagcagg cacaggacac ctggccgcct   1380

ccaggagcct accccctgaa agtgacagag acccagatct catggaaact ggccaggggt   1440

cctgttaacg tcatctcagg gtccagaccc tgaagatttc agaggctgca ggacttctgc   1500

ctgaacctgg ggtcatcgat tcaaactgct ccaagtggtg ggaatcagat ctgtcttgat   1560

gtgtcatcta attaagggaa tcccttgtac ctatggctgc ctgcatctat tctttgtacc   1620

atctgtcttg ccagccagaa gcctctgcct ccctagcttt tctgctatag gtcagagatg   1680

ggctgaactg agcctagcta ccttctctac ccatctcccc catcccccac tgccacaccc   1740

tccccattca gacacttcat ggaccaagaa tgagctggtt tgtcaaacaa catgtgagca   1800

tggtcacaag cacaaagctc aagatgacag ctcttctaag gaaatggaga agctctgttt   1860

ataaaaacaa aaacaaaacc agctgctact cataagttgg accagaggaa gccccttact   1920

atgatctcag gagcttgcaa gaagcaggaa ggggaatgga ataggttaag tttaggccta   1980

tcaacctaag caacagaaat aatctgacac taccttatca ggcaaattgg ggaggggagg   2040

gtgtatctag ctctagttca aattatttgg aagtgttccc tgagaaaccc accagcctaa   2100

gaagctctgg ccccaggctt gtcactagca gctgcagtca acagttcaaa gaagtcatgg   2160

cccaaatcca gtgtgcaccc ctccccattc acagagcctt tttcacaatt ccatttccag   2220

ttcatctatg gcagtccagc cagctcctgg gcagcttgag agggcaaacc caaaacctca   2280

tgacagccag agcctgtctt tcagcattca gtccgcctgg ccggctccag tttccccatg   2340

gggctgcggg acagaggacc attacaacta gatcaaggag cccagaaaac ctccagtagt   2400

ggacaacagg ttttcaccat agcctacgtt aacccatttt tgagccaagc ttcaaccctc   2460

agccttgaaa aacaagtctt taatttaatt tttgtttttt gcctaaatcc aaagaaaaag   2520

ggctgccggg ccaggcgcgg tggctcacgc ctgtaatccc agcactttgg caggccgagg   2580

caggtggatc acctgacgtc agtagtttga gaccagcctg gccaacatgg tgaaaccctg   2640

tatctactaa aaatacaaaa attagccgga cgtggtggtg cgcgcatgta atcccagcta   2700

ctcgggaggc tgaggcggaa gaatcacttg aacccgggag gcggaggttc cagtgagccg   2760

agatggcgct attgcactcc agtctgggta acagggagac tgcatctcaa aaaaaaaaaa   2820

aaaaaaaaaa aagggctgtc catgtattca cacacccctc aaaaaaagcc tttagttcct   2880

actttagcca ctggtttctc agaatccaaa gatcacatat tctagtgtaa cactgcaaga   2940

agtcttgaga aaaagattat tgtagtgttc aaaatatttt tgtattgtta atgcatcatc   3000

atagaaaaac ttttaaacat gagaataaag atacttttta ctgggtttgt ttttcaaagc   3060

ctg                                                                 3063


<210>  2825
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  2825

Met Tyr Lys Glu Thr Val Tyr Ser Ala Phe Asn Leu Leu Met His Tyr 
1               5                   10                  15


Pro Pro Pro Ser Gly Ala Gly Gln His Pro Gln Pro Gln Pro Pro Leu 
            20                  25                  30


His Lys Ala Asn Gln Pro Pro His Gly Val Pro Gln Leu Ser Leu Tyr 
        35                  40                  45


Glu His Phe Asn Ser Pro His Pro Thr Pro Ala Pro Ala Asp Ile Ser 
    50                  55                  60


Gln Lys Gln Val His Arg Pro Leu Gln Thr Pro Asp Leu Ser Gly Phe 
65                  70                  75                  80


Tyr Ser Leu Thr Ser Gly Ser Met Gly Gln Leu Pro His Thr Val Ser 
                85                  90                  95


Trp Phe Thr His Pro Ser Leu Met Leu Gly Ser Gly Val Pro Gly His 
            100                 105                 110


Pro Ala Ala Ile Pro His Pro Ala Ile Val Pro Pro Ser Gly Lys Gln 
        115                 120                 125


Glu Leu Gln Pro Phe Asp Arg Asn Leu Lys Thr Gln Ala Glu Ser Lys 
    130                 135                 140


Ala Glu Lys Glu Ala Lys Lys Pro Thr Ile Lys Lys Pro Leu Asn Ala 
145                 150                 155                 160


Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val Ile Ala Glu Cys 
                165                 170                 175


Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly Arg Arg Trp 
            180                 185                 190


His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu Leu Ala Arg 
        195                 200                 205


Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly Trp Ser Ala Arg 
    210                 215                 220


Asp Asn Tyr Gly Lys Lys Lys Arg Arg Ser Arg Glu Lys His Gln Glu 
225                 230                 235                 240


Ser Thr Thr Gly Gly Lys Arg Asn Ala Phe Gly Thr Tyr Pro Glu Lys 
                245                 250                 255


Ala Ala Ala Pro Ala Pro Phe Leu Pro Met Thr Val Leu 
            260                 265


<210>  2826
<211>  3049
<212>  DNA
<213>  Homo sapiens

<400>  2826
gacagaattg gccaaggttt cttggttgga gggcgggggg tgggaggtca agtaggggcc     60

acctcgggga ggcctgccct ccaggtcctt cccctaaaac ttggcactgc cgatactccc    120

agcccgttcc ttcccaagtc aggaacttgc aggggacccc ttggcaattc tttttctctc    180

aagagcagac agccttcagt cccagccgct gccagggctg gtgtgtctga cccagctgtg    240

gtttttccag gcctgaaggc cccggagtgc accagcggca tgtacaaaga gaccgtctac    300

tccgccttca atctgctcat gcattaccca cccccctcgg gagcagggca gcacccccag    360

ccgcagcccc cgctggtaag tggaccccgc agccagtgcc gccctgtgct tgcagcctcc    420

ttgaccagca caaggccaat cagccccccc acggtgtccc ccaactctct ctctacgaac    480

atttcaacag cccacatccc acccctgcac ctgcggacat cagccagaag caagttcaca    540

ggcctctgca gacccctgac ctctctggct tctactccct gacctcaggc agcatggggc    600

agctccccca cactgtgagc tggttcaccc acccatcctt gatgctaggt tctggtgtac    660

ctggtcaccc agcagccatc ccccacccgg ccattgtgcc cccctcaggg aagcaggagc    720

tgcagccctt cgaccgcaac ctgaagacac aagcagagtc caaggcagag aaggaggcca    780

agaagccaac catcaagaag cccctcaatg ccttcatgct gtacatgaag gagatgagag    840

ccaaggtcat tgcagagtgc acacttaagg agagcgctgc catcaaccag atcctgggcc    900

gcaggtggca cgcgctgtcg cgagaagagc aggccaagta ctatgagctg gcccgcaagg    960

agaggcagct gcacatgcag ctatacccag gctggtcagc gcgggacaac tacgggaaga   1020

agaagaggcg gtcgagggaa aagcaccaag aatccaccac aggaggaaaa agaaatgcat   1080

tcggtactta cccggagaag gccgctgccc cagccccgtt ccttccgatg acagtgctct   1140

aggctgcccc gggtccccag ctccccagga ctcaccctca taccatctgc tgccccgctt   1200

ccccacagaa ctgcttacta gccctgcgga gccggcacct acatccccag gtctctccac   1260

tgctctcagc ctcccaaccc cagggccccc acaggccccc cgcagcaccc tgcagagcac   1320

acaggtacag caacaggaat ctcagagaca ggtggcctag caggcacagg acacctggcc   1380

gcctccagga gcctaccccc tgaaagtgac agagacccag atctcatgga aactggccag   1440

gggtcctgtt aacgtcatct cagggtccag accctgaaga tttcagaggc tgcaggactt   1500

ctgcctgaac ctggggtcat cgattcaaac tgctccaagt ggtgggaatc agatctgtct   1560

tgatgtgtca tctaattaag ggaatccctt gtacctatgg ctgcctgcat ctattctttg   1620

taccatctgt cttgccagcc agaagcctct gcctccctag cttttctgct ataggtcaga   1680

gatgggctga actgagccta gctaccttct ctacccatct cccccatccc ccactgccac   1740

accctcccca ttcagacact tcatggacca agaatgagct ggtttgtcaa acaacatgtg   1800

agcatggtca caagcacaaa gctcaagatg acagctcttc taaggaaatg gagaagctct   1860

gtttataaaa acaaaaacaa aaccagctgc tactcataag ttggaccaga ggaagcccct   1920

tactatgatc tcaggagctt gcaagaagca ggaaggggaa tggaataggt taagtttagg   1980

cctatcaacc taagcaacag aaataatctg acactacctt atcaggcaaa ttggggaggg   2040

gagggtgtat ctagctctag ttcaaattat ttggaagtgt tccctgagaa acccaccagc   2100

ctaagaagct ctggccccag gcttgtcact agcagctgca gtcaacagtt caaagaagtc   2160

atggcccaaa tccagtgtgc acccctcccc attcacagag cctttttcac aattccattt   2220

ccagttcatc tatggcagtc cagccagctc ctgggcagct tgagagggca aacccaaaac   2280

ctcatgacag ccagagcctg tctttcagca ttcagtccgc ctggccggct ccagtttccc   2340

catggggctg cgggacagag gaccattaca actagatcaa ggagcccaga aaacctccag   2400

tagtggacaa caggttttca ccatagccta cgttaaccca tttttgagcc aagcttcaac   2460

cctcagcctt gaaaaacaag tctttaattt aatttttgtt ttttgcctaa atccaaagaa   2520

aaagggctgc cgggccaggc gcggtggctc acgcctgtaa tcccagcact ttggcaggcc   2580

gaggcaggtg gatcacctga cgtcagtagt ttgagaccag cctggccaac atggtgaaac   2640

cctgtatcta ctaaaaatac aaaaattagc cggacgtggt ggtgcgcgca tgtaatccca   2700

gctactcggg aggctgaggc ggaagaatca cttgaacccg ggaggcggag gttccagtga   2760

gccgagatgg cgctattgca ctccagtctg ggtaacaggg agactgcatc tcaaaaaaaa   2820

aaaaaaaaaa aaaaaagggc tgtccatgta ttcacacacc cctcaaaaaa agcctttagt   2880

tcctacttta gccactggtt tctcagaatc caaagatcac atattctagt gtaacactgc   2940

aagaagtctt gagaaaaaga ttattgtagt gttcaaaata tttttgtatt gttaatgcat   3000

catcatagaa aaacttttaa acatgagaat aaagatactt tttactggg               3049


<210>  2827
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  2827

Met Gly Gln Leu Pro His Thr Val Ser Trp Phe Thr His Pro Ser Leu 
1               5                   10                  15


Met Leu Gly Ser Gly Val Pro Gly His Pro Ala Ala Ile Pro His Pro 
            20                  25                  30


Ala Ile Val Pro Pro Ser Gly Lys Gln Glu Leu Gln Pro Phe Asp Arg 
        35                  40                  45


Asn Leu Lys Thr Gln Ala Glu Ser Lys Ala Glu Lys Glu Ala Lys Lys 
    50                  55                  60


Pro Thr Ile Lys Lys Pro Leu Asn Ala Phe Met Leu Tyr Met Lys Glu 
65                  70                  75                  80


Met Arg Ala Lys Val Ile Ala Glu Cys Thr Leu Lys Glu Ser Ala Ala 
                85                  90                  95


Ile Asn Gln Ile Leu Gly Arg Arg Trp His Ala Leu Ser Arg Glu Glu 
            100                 105                 110


Gln Ala Lys Tyr Tyr Glu Leu Ala Arg Lys Glu Arg Gln Leu His Met 
        115                 120                 125


Gln Leu Tyr Pro Gly Trp Ser Ala Arg Asp Asn Tyr Gly Lys Lys Lys 
    130                 135                 140


Arg Arg Ser Arg Glu Lys His Gln Glu Ser Thr Thr Gly Gly Lys Arg 
145                 150                 155                 160


Asn Ala Phe Gly Thr Tyr Pro Glu Lys Ala Ala Ala Pro Ala Pro Phe 
                165                 170                 175


Leu Pro Met Thr Val Leu 
            180


<210>  2828
<211>  531
<212>  DNA
<213>  Homo sapiens

<400>  2828
ttggccaagg tttcttggtt ggagggcggg gggtgggagg tcaagtaggg gccacctcgg     60

ggaggcctgc cctccaggtc cttcccctaa aacttggcac tgccgatact cccagcccgt    120

tccttcccaa gtcaggaact tgcaggggac cccttggcaa ttctttttct ctcaagagca    180

gacagccttc agtcccagcc gctgccaggg ctggtgtgtc tgacccagct gtggtttttc    240

caggcctgaa ggccccggag tgcaccagcg gcatgtacaa agagaccgtc tactccgcct    300

tcaatctgct catgcattac ccacccccct cgggagcagg gcagcacccc cagccgcagc    360

ccccgctgga gagaaaatgc agccccagag aaggatgaga ctggcccagg atcctccaat    420

aaaagcacaa ggccaatcag cccccccacg gtgtccccca actctctctc tacgaacatt    480

tcaacagccc acatcccacc cctgcacctg cggacatcag ccagaagcaa g             531


<210>  2829
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  2829

Met Gln Pro Gln Arg Arg Met Arg Leu Ala Gln Asp Pro Pro Ile Lys 
1               5                   10                  15


Ala Gln Gly Gln Ser Ala Pro Pro Arg Cys Pro Pro Thr Leu Ser Leu 
            20                  25                  30


Arg Thr Phe Gln Gln Pro Thr Ser His Pro Cys Thr Cys Gly His Gln 
        35                  40                  45


Pro Glu 
    50


<210>  2830
<211>  999
<212>  DNA
<213>  Homo sapiens

<400>  2830
gagtcctgcg gtgctgagga aacaggaagt acgggggctg ggcaaggatg gccctggagg     60

aagccaggcc ccatctcccc tgatttaggg gattgaggag ggcccttccc tgtgtcagaa    120

aatcctgtta ggcctgagct aagacaaatg gtcagactca gaatccccag actgggggct    180

agaagatgag gaaagatagc tgtgcttctt ccagggtgtg ctggggtagg cctgggtcct    240

caggccatgc cctgctttag ggggctggag gctataagca acctcccaga caagccaaac    300

ctgagatgag gaggccaata agggttttct ggacagggga gacgcacctc caggaattga    360

gtgcccagaa agaccaagag gctttctagg gggtgggact gcttgggcaa agtcttgggg    420

gctagtgggc ggggtactgg acactgtgac ttgagtggta cccccttcgc tgaggcctgt    480

ggttttggcc accacttttc tttgacagct gggcttcctg tataccctca tcccagtgtc    540

ttcctccctc aggactcgcc acactcaccc accctccttc tcatttttca gcacaaggcc    600

aatcagcccc cccacggtgt cccccaactc tctctctacg aacatttcaa cagcccacat    660

cccacccctg cacctgcgga catcagccag aagcaagttc acaggcctct gcagacccct    720

gacctctctg gcttctactc cctgacctca ggcagcatgg ggcagctccc ccacactgtg    780

agctggtgag tgtgggccca atgggaaagg ggtaccgtgt gctggtcaga ccaagacctg    840

cctgcccttc catttcctcc tccatccctc ttggctggcc accctgctgc cagctctgtt    900

tagatgccag gggctggcca gcaactctgt cctaacctgg ctctgagcta ggggtcctca    960

tgtaccccgg cctgcattcc ccagggagcc tgacatact                           999


<210>  2831
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  2831

Met Gly Lys Gly Tyr Arg Val Leu Val Arg Pro Arg Pro Ala Cys Pro 
1               5                   10                  15


Ser Ile Ser Ser Ser Ile Pro Leu Gly Trp Pro Pro Cys Cys Gln Leu 
            20                  25                  30


Cys Leu Asp Ala Arg Gly Trp Pro Ala Thr Leu Ser 
        35                  40


<210>  2832
<211>  3860
<212>  DNA
<213>  Homo sapiens

<400>  2832
caagagagtt gagcctacag cagattttac ccaccaaggc tgtaaggagg ggacttcagg     60

cagccctgtg ctctcggctt ccacccggtg gcacttggct gtgaggaaag aagtaggggt    120

atttaagcca tctctccact gagccctatt gtgtgccggg cagggttctg ggcaccaggg    180

aagtcggcac tgctgaagcc aactgatcgt taggtccctg ccctctcaga actcagtcta    240

cctcgtgggc aacccaggca aaaaaccaga cagttacagg gcactgttgg tagtgctcta    300

gttagggact gtaggagccc agagaggtac ctcatccagc ttggaatctc agggatttga    360

ggaggaaggg tcacttagct aaggaagacc tgaaggatga ccaggaattg aagcaggcaa    420

agtggtgcaa aacaatccag tgttaacagt ggctgcaatg gccccaggac agatatcagc    480

cctataccgt caaagaaaca gaagcaggct ggaggggccc aggggcctgc taagctgggt    540

cccaggagaa ggataccatt tccatccctc aagcacccat acaagtttat agagggaaac    600

cgcacaagct gccctctggt ggcagatgct tgaaattcca gcagaggccc atctgtctca    660

caggatgggt caaggcctgc ctagcaaggt agggaagtct ttcctcgtgt ctggccagca    720

gccagactgc taacagctat ctctcccaac cacaggccca gccctcctct ctaccccctg    780

tccccttcct gcggatatag acagcacttc cctgccccca ctgcagcccc tggcgccccc    840

taccccaggt tcacccaccc atccttgatg ctaggttctg gtgtacctgg tcacccagca    900

gccatccccc acccggccat tgtgcccccc tcagggaagc aggagctgca gcccttcgac    960

cgcaacctga agacacaagc agagtccaag gcagagaagg aggccaagaa gccaaccatc   1020

aagaagcccc tcaatgcctt catgctgtac atgaaggaga tgagagccaa ggtcattgca   1080

gagtgcacac ttaaggagag cgctgccatc aaccagatcc tgggccgcag ggtgagacca   1140

tgggcaggtg ggctggcagg gatgctcccc gaccatcttc agcctggtgc agcctgctga   1200

ctccctgatg caccccacct gcccctcttc cctgttgcag tggcacgcgc tgtcgcgaga   1260

agagcaggcc aagtactatg agctggcccg caaggagagg cagctgcaca tgcagctata   1320

cccaggctgg tcagcgcggg acaactacgt gagtgcctag tgacacacag caggggtggg   1380

caggggaccc tttgagatac catgccccag gccacaatct cagtaaggaa cgcagaacta   1440

ctgtcctgaa ggcaccgatg aggaagggca cggagggtcc aaggcctccc atggctgcct   1500

cagaagagga caagcccaca tcctattctc cactccagaa tatgctcaca catgagctgt   1560

tacccaacat ttgattgggc cacatgggca gaaggggaga aaggggtctg gaagtcacct   1620

ccttccattc aaactggaga ccagattggg gtgagggaag agcttctaaa tgcactccat   1680

agcagcctag caagaccagc aatcaagaaa caccagcacc ccaaggggaa gaagaagagg   1740

cggtcgaggg aaaagcacca agaatccacc acagaccctg gctcgcctaa gaaatgccgt   1800

gctcgctttg gcctcaacca gcagacggat tggtgtggtc cgtgcaggag gaaaaagaaa   1860

tgcattcggt acttacccgg agaaggccgc tgccccagcc ccgttccttc cgatgacagt   1920

gctctaggct gccccgggtc cccagctccc caggactcac cctcatacca tctgctgccc   1980

cgcttcccca cagaactgct tactagccct gcggagccgg cacctacatc cccaggtctc   2040

tccactgctc tcagcctccc aaccccaggg cccccacagg ccccccgcag caccctgcag   2100

agcacacagg tacagcaaca ggaatctcag agacaggtgg cctagcaggc acaggacacc   2160

tggccgcctc caggagccta ccccctgaaa gtgacagaga cccagatctc atggaaactg   2220

gccaggggtc ctgttaacgt catctcaggg tccagaccct gaagatttca gaggctgcag   2280

gacttctgcc tgaacctggg gtcatcgatt caaactgctc caagtggtgg gaatcagatc   2340

tgtcttgatg tgtcatctaa ttaagggaat cccttgtacc tatggctgcc tgcatctatt   2400

ctttgtacca tctgtcttgc cagccagaag cctctgcctc cctagctttt ctgctatagg   2460

tcagagatgg gctgaactga gcctagctac cttctctacc catctccccc atcccccact   2520

gccacaccct ccccattcag acacttcatg gaccaagaat gagctggttt gtcaaacaac   2580

atgtgagcat ggtcacaagc acaaagctca agatgacagc tcttctaagg aaatggagaa   2640

gctctgttta taaaaacaaa aacaaaacca gctgctactc ataagttgga ccagaggaag   2700

ccccttacta tgatctcagg agcttgcaag aagcaggaag gggaatggaa taggttaagt   2760

ttaggcctat caacctaagc aacagaaata atctgacact accttatcag gcaaattggg   2820

gaggggaggg tgtatctagc tctagttcaa attatttgga agtgttccct gagaaaccca   2880

ccagcctaag aagctctggc cccaggcttg tcactagcag ctgcagtcaa cagttcaaag   2940

aagtcatggc ccaaatccag tgtgcacccc tccccattca cagagccttt ttcacaattc   3000

catttccagt tcatctatgg cagtccagcc agctcctggg cagcttgaga gggcaaaccc   3060

aaaacctcat gacagccaga gcctgtcttt cagcattcag tccgcctggc cggctccagt   3120

ttccccatgg ggctgcggga cagaggacca ttacaactag atcaaggagc ccagaaaacc   3180

tccagtagtg gacaacaggt tttcaccata gcctacgtta acccattttt gagccaagct   3240

tcaaccctca gccttgaaaa acaagtcttt aatttaattt ttgttttttg cctaaatcca   3300

aagaaaaagg gctgccgggc caggcgcggt ggctcacgcc tgtaatccca gcactttggc   3360

aggccgaggc aggtggatca cctgacgtca gtagtttgag accagcctgg ccaacatggt   3420

gaaaccctgt atctactaaa aatacaaaaa ttagccggac gtggtggtgc gcgcatgtaa   3480

tcccagctac tcgggaggct gaggcggaag aatcacttga acccgggagg cggaggttcc   3540

agtgagccga gatggcgcta ttgcactcca gtctgggtaa cagggagact gcatctcaaa   3600

aaaaaaaaaa aaaaaaaaaa agggctgtcc atgtattcac acacccctca aaaaaagcct   3660

ttagttccta ctttagccac tggtttctca gaatccaaag atcacatatt ctagtgtaac   3720

actgcaagaa gtcttgagaa aaagattatt gtagtgttca aaatattttt gtattgttaa   3780

tgcatcatca tagaaaaact tttaaacatg agaataaaga tactttttac tgggtttgtt   3840

tttcaaagcc tgaccctgag                                               3860


<210>  2833
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  2833

Met Ser Cys Tyr Pro Thr Phe Asp Trp Ala Thr Trp Ala Glu Gly Glu 
1               5                   10                  15


Lys Gly Val Trp Lys Ser Pro Pro Ser Ile Gln Thr Gly Asp Gln Ile 
            20                  25                  30


Gly Val Arg Glu Glu Leu Leu Asn Ala Leu His Ser Ser Leu Ala Arg 
        35                  40                  45


Pro Ala Ile Lys Lys His Gln His Pro Lys Gly Lys Lys Lys Arg Arg 
    50                  55                  60


Ser Arg Glu Lys His Gln Glu Ser Thr Thr Asp Pro Gly Ser Pro Lys 
65                  70                  75                  80


Lys Cys Arg Ala Arg Phe Gly Leu Asn Gln Gln Thr Asp Trp Cys Gly 
                85                  90                  95


Pro Cys Arg Arg Lys Lys Lys Cys Ile Arg Tyr Leu Pro Gly Glu Gly 
            100                 105                 110


Arg Cys Pro Ser Pro Val Pro Ser Asp Asp Ser Ala Leu Gly Cys Pro 
        115                 120                 125


Gly Ser Pro Ala Pro Gln Asp Ser Pro Ser Tyr His Leu Leu Pro Arg 
    130                 135                 140


Phe Pro Thr Glu Leu Leu Thr Ser Pro Ala Glu Pro Ala Pro Thr Ser 
145                 150                 155                 160


Pro Gly Leu Ser Thr Ala Leu Ser Leu Pro Thr Pro Gly Pro Pro Gln 
                165                 170                 175


Ala Pro Arg Ser Thr Leu Gln Ser Thr Gln Val Gln Gln Gln Glu Ser 
            180                 185                 190


Gln Arg Gln Val Ala 
        195


<210>  2834
<211>  3148
<212>  DNA
<213>  Homo sapiens

<400>  2834
acagcccagt atagcaagtg tagacatggc accggcagct taatgggcca gctgagtgat     60

ggggaagccc caaggagacc tcaccaggcc tgatgggtca gggagagctt cgcggaaaga    120

gtaatagatc ttttgcgaga agaaaacaag ggaacagcca taactggggc tgccggggaa    180

cggagaggga caggaagcag aggagaagag aaggggctag caacagcagc aggatgctca    240

tgcagggctg tgcaggccct tgggagcagc ctgggttcta ttctttggac gctgggggaa    300

tttcagccga agcaggccag gaacattcag gtgtctctaa tggttactct ggctattgtg    360

tggagagagg cctggaaggg tcaagcagga gagggatgag gcctcacagg gcagccacag    420

gctcctgagg ctgggttggt aggggaagga cgtgagaagg ggacagattc aaaagctact    480

tgggacctat gtagtaacca tctgaatggc aatctatgta gatttttgca gtgtgtctgt    540

gtagtgtgct gggagcaggt atttgtattt atctctgtgt acttatgtct aggccagtag    600

gatagagtat ctatctgttc acctgtgtcc tcaagttatg tattatgcag gggcctctgt    660

gtgtgtccaa aggtctggcc cataattctt ggctcagtgt taactttctt cctgcctcca    720

ggttcaccca cccatccttg atgctaggtt ctggtgtacc tggtcaccca gcagccatcc    780

cccacccggc cattgtgccc ccctcaggga agcaggagct gcagcccttc gaccgcaacc    840

tgaagacaca agcagagtcc aaggcagaga aggaggccaa gaagccaacc atcaagaagc    900

ccctcaatgc cttcatgctg tacatgaagg agatgagagc caaggtcatt gcagagtgca    960

cacttaagga gagcgctgcc atcaaccaga tcctgggccg caggtggcac gcgctgtcgc   1020

gagaagagca ggccaagtac tatgagctgg cccgcaagga gaggcagctg cacatgcagc   1080

tatacccagg ctggtcagcg cgggacaact acgggaagaa gaagaggcgg tcgagggaaa   1140

agcaccaaga atccaccaca ggaggaaaaa gaaatgcatt cggtacttac ccggagaagg   1200

ccgctgcccc agccccgttc cttccgatga cagtgctcta ggctgccccg ggtccccagc   1260

tccccaggac tcaccctcat accatctgct gccccgcttc cccacagaac tgcttactag   1320

ccctgcggag ccggcaccta catccccagg tctctccact gctctcagcc tcccaacccc   1380

agggccccca caggcccccc gcagcaccct gcagagcaca caggtacagc aacaggaatc   1440

tcagagacag gtggcctagc aggcacagga cacctggccg cctccaggag cctaccccct   1500

gaaagtgaca gagacccaga tctcatggaa actggccagg ggtcctgtta acgtcatctc   1560

agggtccaga ccctgaagat ttcagaggct gcaggacttc tgcctgaacc tggggtcatc   1620

gattcaaact gctccaagtg gtgggaatca gatctgtctt gatgtgtcat ctaattaagg   1680

gaatcccttg tacctatggc tgcctgcatc tattctttgt accatctgtc ttgccagcca   1740

gaagcctctg cctccctagc ttttctgcta taggtcagag atgggctgaa ctgagcctag   1800

ctaccttctc tacccatctc ccccatcccc cactgccaca ccctccccat tcagacactt   1860

catggaccaa gaatgagctg gtttgtcaaa caacatgtga gcatggtcac aagcacaaag   1920

ctcaagatga cagctcttct aaggaaatgg agaagctctg tttataaaaa caaaaacaaa   1980

accagctgct actcataagt tggaccagag gaagcccctt actatgatct caggagcttg   2040

caagaagcag gaaggggaat ggaataggtt aagtttaggc ctatcaacct aagcaacaga   2100

aataatctga cactacctta tcaggcaaat tggggagggg agggtgtatc tagctctagt   2160

tcaaattatt tggaagtgtt ccctgagaaa cccaccagcc taagaagctc tggccccagg   2220

cttgtcacta gcagctgcag tcaacagttc aaagaagtca tggcccaaat ccagtgtgca   2280

cccctcccca ttcacagagc ctttttcaca attccatttc cagttcatct atggcagtcc   2340

agccagctcc tgggcagctt gagagggcaa acccaaaacc tcatgacagc cagagcctgt   2400

ctttcagcat tcagtccgcc tggccggctc cagtttcccc atggggctgc gggacagagg   2460

accattacaa ctagatcaag gagcccagaa aacctccagt agtggacaac aggttttcac   2520

catagcctac gttaacccat ttttgagcca agcttcaacc ctcagccttg aaaaacaagt   2580

ctttaattta atttttgttt tttgcctaaa tccaaagaaa aagggctgcc gggccaggcg   2640

cggtggctca cgcctgtaat cccagcactt tggcaggccg aggcaggtgg atcacctgac   2700

gtcagtagtt tgagaccagc ctggccaaca tggtgaaacc ctgtatctac taaaaataca   2760

aaaattagcc ggacgtggtg gtgcgcgcat gtaatcccag ctactcggga ggctgaggcg   2820

gaagaatcac ttgaacccgg gaggcggagg ttccagtgag ccgagatggc gctattgcac   2880

tccagtctgg gtaacaggga gactgcatct caaaaaaaaa aaaaaaaaaa aaaaagggct   2940

gtccatgtat tcacacaccc ctcaaaaaaa gcctttagtt cctactttag ccactggttt   3000

ctcagaatcc aaagatcaca tattctagtg taacactgca agaagtcttg agaaaaagat   3060

tattgtagtg ttcaaaatat ttttgtattg ttaatgcatc atcatagaaa aacttttaaa   3120

catgagaata aagatacttt ttactggg                                      3148


<210>  2835
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  2835

Met Gln Gly Pro Leu Cys Val Ser Lys Gly Leu Ala His Asn Ser Trp 
1               5                   10                  15


Leu Ser Val Asn Phe Leu Pro Ala Ser Arg Phe Thr His Pro Ser Leu 
            20                  25                  30


Met Leu Gly Ser Gly Val Pro Gly His Pro Ala Ala Ile Pro His Pro 
        35                  40                  45


Ala Ile Val Pro Pro Ser Gly Lys Gln Glu Leu Gln Pro Phe Asp Arg 
    50                  55                  60


Asn Leu Lys Thr Gln Ala Glu Ser Lys Ala Glu Lys Glu Ala Lys Lys 
65                  70                  75                  80


Pro Thr Ile Lys Lys Pro Leu Asn Ala Phe Met Leu Tyr Met Lys Glu 
                85                  90                  95


Met Arg Ala Lys Val Ile Ala Glu Cys Thr Leu Lys Glu Ser Ala Ala 
            100                 105                 110


Ile Asn Gln Ile Leu Gly Arg Arg Trp His Ala Leu Ser Arg Glu Glu 
        115                 120                 125


Gln Ala Lys Tyr Tyr Glu Leu Ala Arg Lys Glu Arg Gln Leu His Met 
    130                 135                 140


Gln Leu Tyr Pro Gly Trp Ser Ala Arg Asp Asn Tyr Gly Lys Lys Lys 
145                 150                 155                 160


Arg Arg Ser Arg Glu Lys His Gln Glu Ser Thr Thr Gly Gly Lys Arg 
                165                 170                 175


Asn Ala Phe Gly Thr Tyr Pro Glu Lys Ala Ala Ala Pro Ala Pro Phe 
            180                 185                 190


Leu Pro Met Thr Val Leu 
        195


<210>  2836
<211>  4889
<212>  DNA
<213>  Homo sapiens

<400>  2836
cgatgaggaa gggcacggag ggtccaaggc ctcccatggc tgcctcagaa gaggacaagc     60

ccacatccta ttctccactc cagaatatgc tcacacatga gctgttaccc aacatttgat    120

tgggccacat gggcagaagg ggagaaaggg gtctggaagt cacctccttc cattcaaact    180

ggagaccaga ttggggtgag ggaagagctt ctaaatgcac tccatagcag cctagcaaga    240

ccagcaatca agaaacacca gcaccccaag gggaagaaga agaggcggtc gagggaaaag    300

caccaagaat ccaccacagg tgagaccttc tctcagcagc agtggaggct cctctccatg    360

tccccatttc aagagcagcc ctcctctgac ccaaagggag gaacgcggta cccagctagg    420

agccttcagg gcctggggcc tatgaaaaca aggcctgcat ctcacaagtc aaattcccat    480

gcaagaaaca gctatattat actaagtccc agggaaaccc agcagaactg gcttctgctg    540

ggtagaattg gagtagatgg tgcgttcctc tgccttgcac ccactacctt tgctagctcc    600

actcaccaga gaaaccagca aagaactgac tgtatggttt gatgcttagc ccaaacaatg    660

tcctggctag ttctgctgag actgggagag gctgagctag gccccatgac taggcccagt    720

agacacacag cctactggct ggagcctggc aatttatcac ccccacttca acatttttca    780

tggcagtgca aagtgctcta tgtagagaag cccacaccct gctgcaggcc tccttcctaa    840

gggtgaattc ctgcctctct ggtaactgag actccacatc cctgaccacc tcagccgtgc    900

tgtccccaca cagggaagct ggaggctagg actgggacag agcagggcag agttcctagc    960

cctttttcca aggcaaagaa taggcccttc cttccatctg caagtgtgta gaacagcata   1020

aggtatagcc ttcagcctta tcccttgaag gaatgtaggt caagaatgaa gaaaaactgg   1080

ataaaatggg tagggagttg gggaggaggt gggtggccct agggcataaa aggctggatc   1140

tccatggtct tccttgggcc cctctgcagc ctccatgctg caagggcccc acaagccaca   1200

gagatgagcc agattgacag gactccctcc ctcccattct tcccactgcc tctactgcgt   1260

acctgggtgc ccacctttcc tgatatcttg gctctgggct cttgggctcc cactggggct   1320

ggctgtgcca tggagaggcc cactctgcct atgggggctg tagggtgtct ataactggct   1380

aacactgatg ttacctcttc tttctgggcc ctgctctgcc ccgctgcctg ctcgccctct   1440

gccctgctct acccctctgg catggctgtg agcagaccct ggctcgccta agaaatgccg   1500

tgctcgcttt ggcctcaacc agcagacgga ttggtgtggt ccgtgcaggt gggtttgtcc   1560

ccaccatcgt tctccctttg ctttaagctg cttccctgac tctgcacatg ttccactggg   1620

cctgcagccc actcctttgg cccctcagcc cactagcata ctcagcagat tgggagccca   1680

ggcctcctga gaatagtagt aaatactgaa cacagcgcgt ggagaagacc acttgggtct   1740

aagtgcagga ggattggaga gaaagacaca gaatgttcca gaaaggaagg acagactcaa   1800

gaaggcagct ctgatgccag tgggcctagc aggtcctcag caaacagaca gctcagccac   1860

cactaagggg gcctggagcc cattctacca ggcctcaaag tcattatggc ccatgggctc   1920

cctcacttcc tcttcaagat gggatccctg cctgtaccat cctgagccct taatctgaaa   1980

aagcaaggtg acaacaacac agaaccatct ggttgccagg tagccttatg acttgctatc   2040

ttgtacctac tgataccaaa gggctggaga ggctggggga gaggacccag ggggtaccct   2100

gggctgtctg agggaaaggg ctcatgtgtt tcaccataca acagagaaat acttgtgggt   2160

gtgacaaggt ttacccaaca agtggttaaa gtttcctcag tcagtttcag gccaggcctg   2220

gcagggctaa gatagagggt actccaggca gtaaggccac tggctctaag gaacacttgt   2280

ccagcctctc agtgtaccca ccacactccc tgtccaaggg caaggaggag tttggggtgt   2340

gtctgtgtat ccacatacat atgcacggtg ggaaacaacc ctgtcttcag gggaagttct   2400

attccattca ttccatcaga gacaaactgg cccagagaac tcaaggatgg taatggacaa   2460

gagtcactgt ccatgtcttc ttcctctagc ccagcttgag gactgggatg gctgggcaag   2520

gaagccatag gcattgcggc cccttgcctt ggtgcagatg tgagtcccac aaacacatct   2580

ggagaagctc aaaggccggg actgggagat gactcccttg gaagacagga gagatgactc   2640

ccttggaaga cagatgacag cccataggcc tagtgacaaa aggccccttt gccaccttgt   2700

ggctgttctg ggaactgcac ctgtcctagg tctgggccag accaagcaga atggcagtct   2760

gaggacactg acttaccacc caagtcccag gaagagagga caaggaatca gccaggcctg   2820

tgcaaaggca gcattttttg gttgtggtgt atgactatga attcaccctc tgtttacaga   2880

taactctctt cactattcct aggaggaaaa agaaatgcat tcggtactta cccggagaag   2940

gccgctgccc cagccccgtt ccttccgatg acagtgctct aggctgcccc gggtccccag   3000

ctccccagga ctcaccctca taccatctgc tgccccgctt ccccacagaa ctgcttacta   3060

gccctgcgga gccggcacct acatccccag gtctctccac tgctctcagc ctcccaaccc   3120

cagggccccc acaggccccc cgcagcaccc tgcagagcac acaggtacag caacaggaat   3180

ctcagagaca ggtggcctag caggcacagg acacctggcc gcctccagga gcctaccccc   3240

tgaaagtgac agagacccag atctcatgga aactggccag gggtcctgtt aacgtcatct   3300

cagggtccag accctgaaga tttcagaggc tgcaggactt ctgcctgaac ctggggtcat   3360

cgattcaaac tgctccaagt ggtgggaatc agatctgtct tgatgtgtca tctaattaag   3420

ggaatccctt gtacctatgg ctgcctgcat ctattctttg taccatctgt cttgccagcc   3480

agaagcctct gcctccctag cttttctgct ataggtcaga gatgggctga actgagccta   3540

gctaccttct ctacccatct cccccatccc ccactgccac accctcccca ttcagacact   3600

tcatggacca agaatgagct ggtttgtcaa acaacatgtg agcatggtca caagcacaaa   3660

gctcaagatg acagctcttc taaggaaatg gagaagctct gtttataaaa acaaaaacaa   3720

aaccagctgc tactcataag ttggaccaga ggaagcccct tactatgatc tcaggagctt   3780

gcaagaagca ggaaggggaa tggaataggt taagtttagg cctatcaacc taagcaacag   3840

aaataatctg acactacctt atcaggcaaa ttggggaggg gagggtgtat ctagctctag   3900

ttcaaattat ttggaagtgt tccctgagaa acccaccagc ctaagaagct ctggccccag   3960

gcttgtcact agcagctgca gtcaacagtt caaagaagtc atggcccaaa tccagtgtgc   4020

acccctcccc attcacagag cctttttcac aattccattt ccagttcatc tatggcagtc   4080

cagccagctc ctgggcagct tgagagggca aacccaaaac ctcatgacag ccagagcctg   4140

tctttcagca ttcagtccgc ctggccggct ccagtttccc catggggctg cgggacagag   4200

gaccattaca actagatcaa ggagcccaga aaacctccag tagtggacaa caggttttca   4260

ccatagccta cgttaaccca tttttgagcc aagcttcaac cctcagcctt gaaaaacaag   4320

tctttaattt aatttttgtt ttttgcctaa atccaaagaa aaagggctgc cgggccaggc   4380

gcggtggctc acgcctgtaa tcccagcact ttggcaggcc gaggcaggtg gatcacctga   4440

cgtcagtagt ttgagaccag cctggccaac atggtgaaac cctgtatcta ctaaaaatac   4500

aaaaattagc cggacgtggt ggtgcgcgca tgtaatccca gctactcggg aggctgaggc   4560

ggaagaatca cttgaacccg ggaggcggag gttccagtga gccgagatgg cgctattgca   4620

ctccagtctg ggtaacaggg agactgcatc tcaaaaaaaa aaaaaaaaaa aaaaaagggc   4680

tgtccatgta ttcacacacc cctcaaaaaa agcctttagt tcctacttta gccactggtt   4740

tctcagaatc caaagatcac atattctagt gtaacactgc aagaagtctt gagaaaaaga   4800

ttattgtagt gttcaaaata tttttgtatt gttaatgcat catcatagaa aaacttttaa   4860

acatgagaat aaagatactt tttactggg                                     4889


<210>  2837
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  2837

Met Ser Cys Tyr Pro Thr Phe Asp Trp Ala Thr Trp Ala Glu Gly Glu 
1               5                   10                  15


Lys Gly Val Trp Lys Ser Pro Pro Ser Ile Gln Thr Gly Asp Gln Ile 
            20                  25                  30


Gly Val Arg Glu Glu Leu Leu Asn Ala Leu His Ser Ser Leu Ala Arg 
        35                  40                  45


Pro Ala Ile Lys Lys His Gln His Pro Lys Gly Lys Lys Lys Arg Arg 
    50                  55                  60


Ser Arg Glu Lys His Gln Glu Ser Thr Thr Gly Glu Thr Phe Ser Gln 
65                  70                  75                  80


Gln Gln Trp Arg Leu Leu Ser Met Ser Pro Phe Gln Glu Gln Pro Ser 
                85                  90                  95


Ser Asp Pro Lys Gly Gly Thr Arg Tyr Pro Ala Arg Ser Leu Gln Gly 
            100                 105                 110


Leu Gly Pro Met Lys Thr Arg Pro Ala Ser His Lys Ser Asn Ser His 
        115                 120                 125


Ala Arg Asn Ser Tyr Ile Ile Leu Ser Pro Arg Glu Thr Gln Gln Asn 
    130                 135                 140


Trp Leu Leu Leu Gly Arg Ile Gly Val Asp Gly Ala Phe Leu Cys Leu 
145                 150                 155                 160


Ala Pro Thr Thr Phe Ala Ser Ser Thr His Gln Arg Asn Gln Gln Arg 
                165                 170                 175


Thr Asp Cys Met Val 
            180


<210>  2838
<211>  4322
<212>  DNA
<213>  Homo sapiens

<400>  2838
tgaaaacaag gcctgcatct cacaagtcaa attcccatgc aagaaacagc tatattatac     60

taagtcccag ggaaacccag cagaactggc ttctgctggg tagaattgga gtagatggtg    120

cgttcctctg ccttgcaccc actacctttg ctagctccac tcaccagaga aaccagcaaa    180

gaactgactg tatggtttga tgcttagccc aaacaatgtc ctggctagtt ctgctgagac    240

tgggagaggc tgagctaggc cccatgacta ggcccagtag acacacagcc tactggctgg    300

agcctggcaa tttatcaccc ccacttcaac atttttcatg gcagtgcaaa gtgctctatg    360

tagagaagcc cacaccctgc tgcaggcctc cttcctaagg gtgaattcct gcctctctgg    420

taactgagac tccacatccc tgaccacctc agccgtgctg tccccacaca gggaagctgg    480

aggctaggac tgggacagag cagggcagag ttcctagccc tttttccaag gcaaagaata    540

ggcccttcct tccatctgca agtgtgtaga acagcataag gtatagcctt cagccttatc    600

ccttgaagga atgtaggtca agaatgaacc acagagatga gccagattga caggactccc    660

tccctcccat tcttcccact gcctctactg cgtacctggg tgcccacctt tcctgatatc    720

ttggctctgg gctcttgggc tcccactggg gctggctgtg ccatggagag gcccactctg    780

cctatggggg ctgtagggtg tctataactg gctaacactg atgttacctc ttctttctgg    840

gccctgctct gccccgctgc ctgctcgccc tctgccctgc tctacccctc tggcatggct    900

gtgagcagac cctggctcgc ctaagaaatg ccgtgctcgc tttggcctca accagcagac    960

ggattggtgt ggtccgtgca ggtgggtttg tccccaccat cgttctccct ttgctttaag   1020

ctgcttccct gactctgcac atgttccact gggcctgcag cccactcctt tggcccctca   1080

gcccactagc atactcagca gattgggagc ccaggcctcc tgagaatagt agtaaatact   1140

gaacacagcg cgtggagaag accacttggg tctaagtgca ggaggattgg agagaaagac   1200

acagaatgtt ccagaaagga aggacagact caagaaggca gctctgatgc cagtgggcct   1260

agcaggtcct cagcaaacag acagctcagc caccactaag ggggcctgga gcccattcta   1320

ccaggcctca aagtcattat ggcccatggg ctccctcact tcctcttcaa gatgggatcc   1380

ctgcctgtac catcctgagc ccttaatctg aaaaagcaag gtgacaacaa cacagaacca   1440

tctggttgcc aggtagcctt atgacttgct atcttgtacc tactgatacc aaagggctgg   1500

agaggctggg ggagaggacc cagggggtac cctgggctgt ctgagggaaa gggctcatgt   1560

gtttcaccat acaacagaga aatacttgtg ggtgtgacaa ggtttaccca acaagtggtt   1620

aaagtttcct cagtcagttt caggccaggc ctggcagggc taagatagag ggtactccag   1680

gcagtaaggc cactggctct aaggaacact tgtccagcct ctcagtgtac ccaccacact   1740

ccctgtccaa gggcaaggag gagtttgggg tgtgtctgtg tatccacata catatgcacg   1800

gtgggaaaca accctgtctt caggggaagt tctattccat tcattccatc agagacaaac   1860

tggcccagag aactcaagga tggtaatgga caagagtcac tgtccatgtc ttcttcctct   1920

agcccagctt gaggactggg atggctgggc aaggaagcca taggcattgc ggccccttgc   1980

cttggtgcag atgtgagtcc cacaaacaca tctggagaag ctcaaaggcc gggactggga   2040

gatgactccc ttggaagaca ggagagatga ctcccttgga agacagatga cagcccatag   2100

gcctagtgac aaaaggcccc tttgccacct tgtggctgtt ctgggaactg cacctgtcct   2160

aggtctgggc cagaccaagc agaatggcag tctgaggaca ctgacttacc acccaagtcc   2220

caggaagaga ggacaaggaa tcagccaggc ctgtgcaaag gcagcatttt ttggttgtgg   2280

tgtatgacta tgaattcacc ctctgtttac agataactct cttcactatt cctaggagga   2340

aaaagaaatg cattcggtac ttacccggag aaggccgctg ccccagcccc gttccttccg   2400

atgacagtgc tctaggctgc cccgggtccc cagctcccca ggactcaccc tcataccatc   2460

tgctgccccg cttccccaca gaactgctta ctagccctgc ggagccggca cctacatccc   2520

caggtctctc cactgctctc agcctcccaa ccccagggcc cccacaggcc ccccgcagca   2580

ccctgcagag cacacaggta cagcaacagg aatctcagag acaggtggcc tagcaggcac   2640

aggacacctg gccgcctcca ggagcctacc ccctgaaagt gacagagacc cagatctcat   2700

ggaaactggc caggggtcct gttaacgtca tctcagggtc cagaccctga agatttcaga   2760

ggctgcagga cttctgcctg aacctggggt catcgattca aactgctcca agtggtggga   2820

atcagatctg tcttgatgtg tcatctaatt aagggaatcc cttgtaccta tggctgcctg   2880

catctattct ttgtaccatc tgtcttgcca gccagaagcc tctgcctccc tagcttttct   2940

gctataggtc agagatgggc tgaactgagc ctagctacct tctctaccca tctcccccat   3000

cccccactgc cacaccctcc ccattcagac acttcatgga ccaagaatga gctggtttgt   3060

caaacaacat gtgagcatgg tcacaagcac aaagctcaag atgacagctc ttctaaggaa   3120

atggagaagc tctgtttata aaaacaaaaa caaaaccagc tgctactcat aagttggacc   3180

agaggaagcc ccttactatg atctcaggag cttgcaagaa gcaggaaggg gaatggaata   3240

ggttaagttt aggcctatca acctaagcaa cagaaataat ctgacactac cttatcaggc   3300

aaattgggga ggggagggtg tatctagctc tagttcaaat tatttggaag tgttccctga   3360

gaaacccacc agcctaagaa gctctggccc caggcttgtc actagcagct gcagtcaaca   3420

gttcaaagaa gtcatggccc aaatccagtg tgcacccctc cccattcaca gagccttttt   3480

cacaattcca tttccagttc atctatggca gtccagccag ctcctgggca gcttgagagg   3540

gcaaacccaa aacctcatga cagccagagc ctgtctttca gcattcagtc cgcctggccg   3600

gctccagttt ccccatgggg ctgcgggaca gaggaccatt acaactagat caaggagccc   3660

agaaaacctc cagtagtgga caacaggttt tcaccatagc ctacgttaac ccatttttga   3720

gccaagcttc aaccctcagc cttgaaaaac aagtctttaa tttaattttt gttttttgcc   3780

taaatccaaa gaaaaagggc tgccgggcca ggcgcggtgg ctcacgcctg taatcccagc   3840

actttggcag gccgaggcag gtggatcacc tgacgtcagt agtttgagac cagcctggcc   3900

aacatggtga aaccctgtat ctactaaaaa tacaaaaatt agccggacgt ggtggtgcgc   3960

gcatgtaatc ccagctactc gggaggctga ggcggaagaa tcacttgaac ccgggaggcg   4020

gaggttccag tgagccgaga tggcgctatt gcactccagt ctgggtaaca gggagactgc   4080

atctcaaaaa aaaaaaaaaa aaaaaaaaag ggctgtccat gtattcacac acccctcaaa   4140

aaaagccttt agttcctact ttagccactg gtttctcaga atccaaagat cacatattct   4200

agtgtaacac tgcaagaagt cttgagaaaa agattattgt agtgttcaaa atatttttgt   4260

attgttaatg catcatcata gaaaaacttt taaacatgag aataaagata ctttttactg   4320

gg                                                                  4322


<210>  2839
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  2839

Met Cys His Leu Ile Lys Gly Ile Pro Cys Thr Tyr Gly Cys Leu His 
1               5                   10                  15


Leu Phe Phe Val Pro Ser Val Leu Pro Ala Arg Ser Leu Cys Leu Pro 
            20                  25                  30


Ser Phe Ser Ala Ile Gly Gln Arg Trp Ala Glu Leu Ser Leu Ala Thr 
        35                  40                  45


Phe Ser Thr His Leu Pro His Pro Pro Leu Pro His Pro Pro His Ser 
    50                  55                  60


Asp Thr Ser Trp Thr Lys Asn Glu Leu Val Cys Gln Thr Thr Cys Glu 
65                  70                  75                  80


His Gly His Lys His Lys Ala Gln Asp Asp Ser Ser Ser Lys Glu Met 
                85                  90                  95


Glu Lys Leu Cys Leu 
            100


<210>  2840
<211>  1906
<212>  DNA
<213>  Homo sapiens

<400>  2840
gctgcctgct cgccctctgc cctgctctac ccctctggca tggctgtgag cagaccctgg     60

ctcgcctaag aaatgccgtg ctcgctttgg cctcaaccag cagacggatt ggtgtggtcc    120

gtgcaggtgg gtttgtcccc accatcgttc tccctttgct ttaagctgct tccctgactc    180

tgcacatgtt ccactgggcc tgcagcccac tcctttggcc cctcagccca ctagcatact    240

cagcagattg ggagcccagg cctcctgaga atagtagtaa atactgaaca cagcgcgtgg    300

agaagaccac ttgggtctaa gtgcaggagg attggagaga aagacacaga atgacttctg    360

cctgaacctg gggtcatcga ttcaaactgc tccaagtggt gggaatcaga tctgtcttga    420

tgtgtcatct aattaaggga atcccttgta cctatggctg cctgcatcta ttctttgtac    480

catctgtctt gccagccaga agcctctgcc tccctagctt ttctgctata ggtcagagat    540

gggctgaact gagcctagct accttctcta cccatctccc ccatccccca ctgccacacc    600

ctccccattc agacacttca tggaccaaga atgagctggt ttgtcaaaca acatgtgagc    660

atggtcacaa gcacaaagct caagatgaca gctcttctaa ggaaatggag aagctctgtt    720

tataaaaaca aaaacaaaac cagctgctac tcataagttg gaccagagga agccccttac    780

tatgatctca ggagcttgca agaagcagga aggggaatgg aataggttaa gtttaggcct    840

atcaacctaa gcaacagaaa taatctgaca ctaccttatc aggcaaattg gggaggggag    900

ggtgtatcta gctctagttc aaattatttg gaagtgttcc ctgagaaacc caccagccta    960

agaagctctg gccccaggct tgtcactagc agctgcagtc aacagttcaa agaagtcatg   1020

gcccaaatcc agtgtgcacc cctccccatt cacagagcct ttttcacaat tccatttcca   1080

gttcatctat ggcagtccag ccagctcctg ggcagcttga gagggcaaac ccaaaacctc   1140

atgacagcca gagcctgtct ttcagcattc agtccgcctg gccggctcca gtttccccat   1200

ggggctgcgg gacagaggac cattacaact agatcaagga gcccagaaaa cctccagtag   1260

tggacaacag gttttcacca tagcctacgt taacccattt ttgagccaag cttcaaccct   1320

cagccttgaa aaacaagtct ttaatttaat ttttgttttt tgcctaaatc caaagaaaaa   1380

gggctgccgg gccaggcgcg gtggctcacg cctgtaatcc cagcactttg gcaggccgag   1440

gcaggtggat cacctgacgt cagtagtttg agaccagcct ggccaacatg gtgaaaccct   1500

gtatctacta aaaatacaaa aattagccgg acgtggtggt gcgcgcatgt aatcccagct   1560

actcgggagg ctgaggcgga agaatcactt gaacccggga ggcggaggtt ccagtgagcc   1620

gagatggcgc tattgcactc cagtctgggt aacagggaga ctgcatctca aaaaaaaaaa   1680

aaaaaaaaaa aaagggctgt ccatgtattc acacacccct caaaaaaagc ctttagttcc   1740

tactttagcc actggtttct cagaatccaa agatcacata ttctagtgta acactgcaag   1800

aagtcttgag aaaaagatta ttgtagtgtt caaaatattt ttgtattgtt aatgcatcat   1860

catagaaaaa cttttaaaca tgagaataaa gatacttttt actggg                  1906


<210>  2841
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  2841

Met Cys His Leu Ile Lys Gly Ile Pro Cys Thr Tyr Gly Cys Leu His 
1               5                   10                  15


Leu Phe Phe Val Pro Ser Val Leu Pro Ala Arg Ser Leu Cys Leu Pro 
            20                  25                  30


Ser Phe Ser Ala Ile Gly Gln Arg Trp Ala Glu Leu Ser Leu Ala Thr 
        35                  40                  45


Phe Ser Thr His Leu Pro His Pro Pro Leu Pro His Pro Pro His Ser 
    50                  55                  60


Asp Thr Ser Trp Thr Lys Asn Glu Leu Val Cys Gln Thr Thr Cys Glu 
65                  70                  75                  80


His Gly His Lys His Lys Ala Gln Asp Asp Ser Ser Ser Lys Glu Met 
                85                  90                  95


Glu Lys Leu Cys Leu 
            100


<210>  2842
<211>  1372
<212>  DNA
<213>  Homo sapiens

<400>  2842
ggctgcaaac tacttagaca tcaaaggttt gcttgatgtt acatgcaaga ctgttgccaa     60

tatgatcaag gggaaaactc ctgaggagat tcgcaagacc ttcaatatca aaaatgactt    120

tactgaagag gaggaagccc aggtacgcaa agagaaccag tggtgtgaag agaagtgaaa    180

ttttgagcac agatcccaaa ccttacggcc aagtttcttc tagtatgatg gaaagtttct    240

tttttctttg ctctgaataa aactgaactg tgggttctct ataagtggca ttttgggctt    300

tccctctttt ttgtaaagca atgtctgcct agtttattgt ccagttaact ttagtgacct    360

tttaaaagtt ggcattgtaa ataaaacaac ttgcaaaaaa gttttctgga atagaattaa    420

caaaatatta tctttattca tgagttggaa actggaaaaa ggcttcttga agtaaatgtt    480

ctgagtggag ctactaggat gtcttccagc ctcctgcagt caaggagtac cactgtattg    540

attagcctgt atgtagcagg gctcccttca ttgcatctga ggacttgttt tctttttctt    600

tatttttaat cctcttagtt ttaaatatat tgcctagaga ctcagttact acccagtttg    660

tggttttttg ggagaaatgt aactggacag ttagcttttc aattaaaaag acacttaacc    720

catgtgggat gtcatctttt tataattagt gttcccatgt ggagaaaatt attcacacta    780

cttgcatgta aagaataatt taacttttaa cattaaaata tgtggtaaaa cccagaaagc    840

atccatcatg aatgcaagat actttcaata aaaagtaagt tatatagtag gtagttaagt    900

ttgcttttgt ggacttaaat gtgtctcttc acttaaatgg gttgaatgtg tatatatttg    960

ttcagcttga aaagacttag tttatatcct agctcactgg aggctgctga cataaccata   1020

acttctgtcc cttctaattg tcatttatat gcctaactgg agctagtact ttaattctta   1080

acacaaaatt actctgccat tgtttccagc ttccctccta caatagaatg aagttttttt   1140

gatggcttga gatggctcac aaattttgat ttttttttct tccttgtgct cccttttttt   1200

ctccttgctt ttccagttaa catctatatt cacatgtaat cttgttttct cttcacattc   1260

actgagttgt tcaggctcag atcatccctt gacagtagtt tgccttcatc tcacctttca   1320

tttgtcccaa attcacctta tttaataaag tcccatatgt tgtctcactt aa           1372


<210>  2843
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  2843

Met Thr Leu Leu Lys Arg Arg Lys Pro Arg Tyr Ala Lys Arg Thr Ser 
1               5                   10                  15


Gly Val Lys Arg Ser Glu Ile Leu Ser Thr Asp Pro Lys Pro Tyr Gly 
            20                  25                  30


Gln Val Ser Ser Ser Met Met Glu Ser Phe Phe Phe Leu Cys Ser Glu 
        35                  40                  45


<210>  2844
<211>  3629
<212>  DNA
<213>  Homo sapiens

<400>  2844
aaaacaaaaa cctttcgctg gccaggcaca gtggctcata gctgtaatcc caacactttg     60

ggagggcaag gtgggtgaat tgcttgagtt caggagtttg caacatgatg aaaccttatc    120

tctacaaaaa caaaatacaa aaatgagcca ggtgtggtgg catgcacctg tagttgcagc    180

tacttgggag gctgaggtgg gaggatcgct taagcacagg aggtcgagtg agccatgatc    240

gcggcactgc attccagcct gggtgacaca gtgagatctt gtctcaaaaa caaacaaaca    300

accctttgct tggcttttcc ttattgaaat tgttctttct tttttttttt ttggatcctg    360

gcaatgtttc ttggctctgc cattttctct cagcattgtt tactcctcca acattttgct    420

atgaaaaagt tttagccata cagaaaaatg gaaagaatta cacagtagac aaccatgtag    480

ccactgccta gattctacaa ctgaaaacac tttcagtatt gattttggtc tttatgctgg    540

tatgtatagt ctaagtaatc agcttcctga aactttatgg agtaattatt ctcctattaa    600

ggaaattttg gggcttttcc tgctttgttc ctacaccaaa tagtctcaca catgtgtcta    660

gggtatttgg aatttgctgg ttacaatata tgtacatatt cagcttttct gaggagtgct    720

ggattagctt tcaaaggggt tataccaatt tatactctct agaagagttt gtgtttcctt    780

tccactattg cccaacaatt agtatcagtt tcttgatttt ttttcaatct agagaagtat    840

ctgtagtgtt agttttgctt ctagtaaagt tgagcgttcc ttatgtttgg ctattcagat    900

ttcatttatt ggctgtacat attaacccat ttctctttaa tgatttttga aagattttat    960

attctctcag ctaatcattg ttgtacatat tgcaggtatc ttccagtcat tgtcctaact   1020

tttctttttg catagaagct ttttaatgta gtcaagtaca gtactctgtc tgcatggctt   1080

gcttttatct aataagatct tctcccttct agggttataa tgattcttca agcttcattt   1140

ttgtttttca agcttggctg ttaatggctc aagtcaacct ctagctagtt attattccaa   1200

tatagggata agttgtccca gcagtggaat gagtaccttg tgacaaagtg ccacagagga   1260

atgaactttt gttgttgtag gtcattcagt ggtgcaccca ccacaaggat gaccctcctc   1320

ctcctgaaga tgatgagaac aaagaaaagc gaacagatga tatccctgtt tgggaccaag   1380

aattcctgaa agttgaccaa ggaacacttt ttgaactcat tctggctgca aactacttag   1440

acatcaaagg tttgcttgat gttacatgca agactgttgc caatatgatc aaggggaaaa   1500

ctcctgagga gattcgcaag accttcaata tcaaaaatga ctttactgaa gaggaggaag   1560

cccaggtagg tagcacacag ttttgtcttt gatcacatgc tcttaaaaag ggagtaacac   1620

ctataacatg ccagcaaaag aggtgactgt atcaagtagt cttgatactt tagggataat   1680

atgtacttaa tgtgtcttaa acatactctt actgttctgt ctttatgaat ctgaacactt   1740

agatgatact gcattttaag cataagaaca attagttttc aatgagaaga gctcttgtta   1800

atgtattaac agttactagt tttggcacct gcaactttct gtatagacca tacatatctg   1860

acatcagaaa agcaggccct agagagaagt atatactagg gtactttaga gcaacttaat   1920

gaggggagga aatgaaagaa tagatcagaa tgattttgtt gacatgacta cagactgaaa   1980

taatgtgaat gaattaactg aatttgctct gtcaacttta gtaaattgcc cattgccttt   2040

gctttgttca taatttcagc agggcagaat aaaaaccatg ggaggcaaag aaaggaaatc   2100

cggaaatata gtcttaacct ggtgttgttc taattttcca tctgttcttc tgactcaact   2160

cactggctat cgatgaatca gtaggtagta tttataagtc ttaggaaaga ctactcaagt   2220

taaggtactt ccctatatcc atctctttta ggtacgcaaa gagaaccagt ggtgtgaaga   2280

gaagtgaaat gttgtgcctg acactgtaac actgtaagga ttgttccaaa tactagttgc   2340

actgctctgt ttataattgt taatattaga caaacagtag acaaatgcag cagcaagtca   2400

attgtattag cagaatattg tcctcattgc atgtgtagtt tgagcacaga tcccaaacct   2460

tacggccaag tttcttctag tatgatggaa agtttctttt ttctttgctc tgaataaaac   2520

tgaactgtgg gttctctata agtggcattt tgggctttcc ctcttttttg taaagcaatg   2580

tctgcctagt ttattgtcca gttaacttta gtgacctttt aaaagttggc attgtaaata   2640

aaacaacttg caaaaaagtt ttctggaata gaattaacaa aatattatct ttattcatga   2700

gttggaaact ggaaaaaggc ttcttgaagt aaatgttctg agtggagcta ctaggatgtc   2760

ttccagcctc ctgcagtcaa ggagtaccac tgtattgatt agcctgtatg tagcagggct   2820

cccttcattg catctgagga cttgttttct ttttctttat ttttaatcct cttagtttta   2880

aatatattgc ctagagactc agttactacc cagtttgtgg ttttttggga gaaatgtaac   2940

tggacagtta gcttttcaat taaaaagaca cttaacccat gtgggatgtc atctttttat   3000

aattagtgtt cccatgtgga gaaaattatt cacactactt gcatgtaaag aataatttaa   3060

cttttaacat taaaatatgt ggtaaaaccc agaaagcatc catcatgaat gcaagatact   3120

ttcaataaaa agtaagttat atagtaggta gttaagtttg cttttgtgga cttaaatgtg   3180

tctcttcact taaatgggtt gaatgtgtat atatttgttc agcttgaaaa gacttagttt   3240

atatcctagc tcactggagg ctgctgacat aaccataact tctgtccctt ctaattgtca   3300

tttatatgcc taactggagc tagtacttta attcttaaca caaaattact ctgccattgt   3360

ttccagcttc cctcctacaa tagaatgaag tttttttgat ggcttgagat ggctcacaaa   3420

ttttgatttt tttttcttcc ttgtgctccc tttttttctc cttgcttttc cagttaacat   3480

ctatattcac atgtaatctt gttttctctt cacattcact gagttgttca ggctcagatc   3540

atcccttgac agtagtttgc cttcatctca cctttcattt gtcccaaatt caccttattt   3600

aataaagtcc catatgttgt ctcacttaa                                     3629


<210>  2845
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  2845

Met Tyr Ile Phe Ser Phe Ser Glu Glu Cys Trp Ile Ser Phe Gln Arg 
1               5                   10                  15


Gly Tyr Thr Asn Leu Tyr Ser Leu Glu Glu Phe Val Phe Pro Phe His 
            20                  25                  30


Tyr Cys Pro Thr Ile Ser Ile Ser Phe Leu Ile Phe Phe Gln Ser Arg 
        35                  40                  45


Glu Val Ser Val Val Leu Val Leu Leu Leu Val Lys Leu Ser Val Pro 
    50                  55                  60


Tyr Val Trp Leu Phe Arg Phe His Leu Leu Ala Val His Ile Asn Pro 
65                  70                  75                  80


Phe Leu Phe Asn Asp Phe 
                85


<210>  2846
<211>  1993
<212>  DNA
<213>  Homo sapiens

<400>  2846
gttgtcgacc ctgttcttcg ggagacccta ccaggttccg ttcacctgcc ccgcccccga     60

ctcagcgagg cctcctctgg ccgggcgtcc tcacggcgct ccataaacat aaatgagcat    120

attctgatgt actctttgga tctgaactca tcttcacaga tgccttcaat taagttgcag    180

agttctgatg gagagatatt tgaagttgat gtggaaattg ccaaacaatc tgtgactatt    240

aagaccatgt tggaagattt gggaatggat gatgaaggag atgatgaccc agttcctcta    300

ccaaatgtga atgcagcaat attaaaaaag gtcattcagt ggtgcaccca ccacaaggat    360

gaccctcctc ctcctgaaga tgatgagaac aaagaaaagc gaacagatga tatccctgtt    420

tgggaccaag aattcctgaa agttgaccaa ggaacacttt ttgaactcat tctggctgca    480

aactacttag acatcaaagg tttgcttgat gttacatgca agactgttgc caatatgatc    540

aaggggaaaa ctcctgagga gattcgcaag accttcaata tcaaaaatga ctttactgaa    600

gaggaggaag cccaggtacg caaagagaac cagtggtgtg aagagaagtg aaatgttgtg    660

cctgacactg taacactgta aggattgttc caaatactag ttgcactgct ctgtttataa    720

ttgttaatat tagacaaaca gtagacaaat gcagcagcaa gtcaattgta ttagcagaat    780

attgtcctca ttgcatgtgt agtttgagca cagatcccaa accttacggc caagtttctt    840

ctagtatgat ggaaagtttc ttttttcttt gctctgaata aaactgaact gtgggttctc    900

tataagtggc attttgggct ttccctcttt tttgtaaagc aatgtctgcc tagtttattg    960

tccagttaac tttagtgacc ttttaaaagt tggcattgta aataaaacaa cttgcaaaaa   1020

agttttctgg aatagaatta acaaaatatt atctttattc atgagttgga aactggaaaa   1080

aggcttcttg aagtaaatgt tctgagtgga gctactagga tgtcttccag cctcctgcag   1140

tcaaggagta ccactgtatt gattagcctg tatgtagcag ggctcccttc attgcatctg   1200

aggacttgtt ttctttttct ttatttttaa tcctcttagt tttaaatata ttgcctagag   1260

actcagttac tacccagttt gtggtttttt gggagaaatg taactggaca gttagctttt   1320

caattaaaaa gacacttaac ccatgtggga tgtcatcttt ttataattag tgttcccatg   1380

tggagaaaat tattcacact acttgcatgt aaagaataat ttaactttta acattaaaat   1440

atgtggtaaa acccagaaag catccatcat gaatgcaaga tactttcaat aaaaagtaag   1500

ttatatagta ggtagttaag tttgcttttg tggacttaaa tgtgtctctt cacttaaatg   1560

ggttgaatgt gtatatattt gttcagcttg aaaagactta gtttatatcc tagctcactg   1620

gaggctgctg acataaccat aacttctgtc ccttctaatt gtcatttata tgcctaactg   1680

gagctagtac tttaattctt aacacaaaat tactctgcca ttgtttccag cttccctcct   1740

acaatagaat gaagtttttt tgatggcttg agatggctca caaattttga tttttttttc   1800

ttccttgtgc tccctttttt tctccttgct tttccagtta acatctatat tcacatgtaa   1860

tcttgttttc tcttcacatt cactgagttg ttcaggctca gatcatccct tgacagtagt   1920

ttgccttcat ctcacctttc atttgtccca aattcacctt atttaataaa gtcccatatg   1980

ttgtctcact taa                                                      1993


<210>  2847
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  2847

Met Tyr Ser Leu Asp Leu Asn Ser Ser Ser Gln Met Pro Ser Ile Lys 
1               5                   10                  15


Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val Asp Val Glu Ile Ala 
            20                  25                  30


Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu Asp Leu Gly Met Asp 
        35                  40                  45


Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro Asn Val Asn Ala Ala 
    50                  55                  60


Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His His Lys Asp Asp Pro 
65                  70                  75                  80


Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys Arg Thr Asp Asp Ile 
                85                  90                  95


Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp Gln Gly Thr Leu Phe 
            100                 105                 110


Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile Lys Gly Leu Leu Asp 
        115                 120                 125


Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys Gly Lys Thr Pro Glu 
    130                 135                 140


Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp Phe Thr Glu Glu Glu 
145                 150                 155                 160


Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys Glu Glu Lys 
                165                 170


<210>  2848
<211>  2208
<212>  DNA
<213>  Homo sapiens

<400>  2848
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa gatttgggaa    480

tggatgatga aggagatgat gacccagttc ctctaccaaa tgtgaatgca gcaatattaa    540

aaaaggtcat tcagtggtgc acccaccaca aggatgaccc tcctcctcct gaagatgatg    600

agaacaaaga aaagcgaaca gatgatatcc ctgtttggga ccaagaattc ctgaaatata    660

ctttaaggaa aacaactgtc tctttacagg ctgcaaacta cttagacatc aaaggtttgc    720

ttgatgttac atgcaagact gttgccaata tgatcaaggg gaaaactcct gaggagattc    780

gcaagacctt caatatcaaa aatgacttta ctgaagagga ggaagcccag gtacgcaaag    840

agaaccagtg gtgtgaagag aagtgaaatg ttgtgcctga cactgtaaca ctgtaaggat    900

tgttccaaat actagttgca ctgctctgtt tataattgtt aatattagac aaacagtaga    960

caaatgcagc agcaagtcaa ttgtattagc agaatattgt cctcattgca tgtgtagttt   1020

gagcacagat cccaaacctt acggccaagt ttcttctagt atgatggaaa gtttcttttt   1080

tctttgctct gaataaaact gaactgtggg ttctctataa gtggcatttt gggctttccc   1140

tcttttttgt aaagcaatgt ctgcctagtt tattgtccag ttaactttag tgacctttta   1200

aaagttggca ttgtaaataa aacaacttgc aaaaaagttt tctggaatag aattaacaaa   1260

atattatctt tattcatgag ttggaaactg gaaaaaggct tcttgaagta aatgttctga   1320

gtggagctac taggatgtct tccagcctcc tgcagtcaag gagtaccact gtattgatta   1380

gcctgtatgt agcagggctc ccttcattgc atctgaggac ttgttttctt tttctttatt   1440

tttaatcctc ttagttttaa atatattgcc tagagactca gttactaccc agtttgtggt   1500

tttttgggag aaatgtaact ggacagttag cttttcaatt aaaaagacac ttaacccatg   1560

tgggatgtca tctttttata attagtgttc ccatgtggag aaaattattc acactacttg   1620

catgtaaaga ataatttaac ttttaacatt aaaatatgtg gtaaaaccca gaaagcatcc   1680

atcatgaatg caagatactt tcaataaaaa gtaagttata tagtaggtag ttaagtttgc   1740

ttttgtggac ttaaatgtgt ctcttcactt aaatgggttg aatgtgtata tatttgttca   1800

gcttgaaaag acttagttta tatcctagct cactggaggc tgctgacata accataactt   1860

ctgtcccttc taattgtcat ttatatgcct aactggagct agtactttaa ttcttaacac   1920

aaaattactc tgccattgtt tccagcttcc ctcctacaat agaatgaagt ttttttgatg   1980

gcttgagatg gctcacaaat tttgattttt ttttcttcct tgtgctccct ttttttctcc   2040

ttgcttttcc agttaacatc tatattcaca tgtaatcttg ttttctcttc acattcactg   2100

agttgttcag gctcagatca tcccttgaca gtagtttgcc ttcatctcac ctttcatttg   2160

tcccaaattc accttattta ataaagtccc atatgttgtc tcacttaa                2208


<210>  2849
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  2849

Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Tyr Thr 
                85                  90                  95


Leu Arg Lys Thr Thr Val Ser Leu Gln Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp 
    130                 135                 140


Phe Thr Glu Glu Glu Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys 
145                 150                 155                 160


Glu Glu Lys 



<210>  2850
<211>  2208
<212>  DNA
<213>  Homo sapiens

<400>  2850
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa gatttgggaa    480

tggatgatga aggagatgat gacccagttc ctctaccaaa tgtgaatgca gcaatattaa    540

aaaaggtcat tcagtggtgc acccaccaca aggatgaccc tcctcctcct gaagatgatg    600

agaacaaaga aaagcgaaca gatgatatcc ctgtttggga ccaagaattc ctgaaagttg    660

accaaggaac actttttgaa ctcattctgg ctgcaaacta cttagacatc aaaggtttgc    720

ttgatgttac atgcaagact gttgccaata tgatcaaggg gaaaactcct gaggagattc    780

gcaagacctt caatatcaaa aatgacttta ctgaagagga ggaagcccag gtacgcaaag    840

agaaccagtg gtgtgaagag aagtgaaatg ttgtgcctga cactgtaaca ctgtaaggat    900

tgttccaaat actagttgca ctgctctgtt tataattgtt aatattagac aaacagtaga    960

caaatgcagc agcaagtcaa ttgtattagc agaatattgt cctcattgca tgtgtagttt   1020

gagcacagat cccaaacctt acggccaagt ttcttctagt atgatggaaa gtttcttttt   1080

tctttgctct gaataaaact gaactgtggg ttctctataa gtggcatttt gggctttccc   1140

tcttttttgt aaagcaatgt ctgcctagtt tattgtccag ttaactttag tgacctttta   1200

aaagttggca ttgtaaataa aacaacttgc aaaaaagttt tctggaatag aattaacaaa   1260

atattatctt tattcatgag ttggaaactg gaaaaaggct tcttgaagta aatgttctga   1320

gtggagctac taggatgtct tccagcctcc tgcagtcaag gagtaccact gtattgatta   1380

gcctgtatgt agcagggctc ccttcattgc atctgaggac ttgttttctt tttctttatt   1440

tttaatcctc ttagttttaa atatattgcc tagagactca gttactaccc agtttgtggt   1500

tttttgggag aaatgtaact ggacagttag cttttcaatt aaaaagacac ttaacccatg   1560

tgggatgtca tctttttata attagtgttc ccatgtggag aaaattattc acactacttg   1620

catgtaaaga ataatttaac ttttaacatt aaaatatgtg gtaaaaccca gaaagcatcc   1680

atcatgaatg caagatactt tcaataaaaa gtaagttata tagtaggtag ttaagtttgc   1740

ttttgtggac ttaaatgtgt ctcttcactt aaatgggttg aatgtgtata tatttgttca   1800

gcttgaaaag acttagttta tatcctagct cactggaggc tgctgacata accataactt   1860

ctgtcccttc taattgtcat ttatatgcct aactggagct agtactttaa ttcttaacac   1920

aaaattactc tgccattgtt tccagcttcc ctcctacaat agaatgaagt ttttttgatg   1980

gcttgagatg gctcacaaat tttgattttt ttttcttcct tgtgctccct ttttttctcc   2040

ttgcttttcc agttaacatc tatattcaca tgtaatcttg ttttctcttc acattcactg   2100

agttgttcag gctcagatca tcccttgaca gtagtttgcc ttcatctcac ctttcatttg   2160

tcccaaattc accttattta ataaagtccc atatgttgtc tcacttaa                2208


<210>  2851
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  2851

Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95


Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp 
    130                 135                 140


Phe Thr Glu Glu Glu Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys 
145                 150                 155                 160


Glu Glu Lys 



<210>  2852
<211>  2894
<212>  DNA
<213>  Homo sapiens

<400>  2852
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa gatttgggaa    480

tggatgatga aggagatgat gacccagttc ctctaccaaa tgtgaatgca gcaatattaa    540

aaaaggtcat tcagtggtgc acccaccaca aggatgaccc tcctcctcct gaagatgatg    600

agaacaaaga aaagcgaaca gatgatatcc ctgtttggga ccaagaattc ctgaaagttg    660

accaaggaac actttttgaa ctcattctgg ctgcaaacta cttagacatc aaaggtttgc    720

ttgatgttac atgcaagact gttgccaata tgatcaaggg gaaaactcct gaggagattc    780

gcaagacctt caatatcaaa aatgacttta ctgaagagga ggaagcccag gtaggtagca    840

cacagttttg tctttgatca catgctctta aaaagggagt aacacctata acatgccagc    900

aaaagaggtg actgtatcaa gtagtcttga tactttaggg ataatatgta cttaatgtgt    960

cttaaacata ctcttactgt tctgtcttta tgaatctgaa cacttagatg atactgcatt   1020

ttaagcataa gaacaattag ttttcaatga gaagagctct tgttaatgta ttaacagtta   1080

ctagttttgg cacctgcaac tttctgtata gaccatacat atctgacatc agaaaagcag   1140

gccctagaga gaagtatata ctagggtact ttagagcaac ttaatgaggg gaggaaatga   1200

aagaatagat cagaatgatt ttgttgacat gactacagac tgaaataatg tgaatgaatt   1260

aactgaattt gctctgtcaa ctttagtaaa ttgcccattg cctttgcttt gttcataatt   1320

tcagcagggc agaataaaaa ccatgggagg caaagaaagg aaatccggaa atatagtctt   1380

aacctggtgt tgttctaatt ttccatctgt tcttctgact caactcactg gctatcgatg   1440

aatcagtagg tagtatttat aagtcttagg aaagactact caagttaagg tacttcccta   1500

tatccatctc ttttaggtac gcaaagagaa ccagtggtgt gaagagaagt gaaatgttgt   1560

gcctgacact gtaacactgt aaggattgtt ccaaatacta gttgcactgc tctgtttata   1620

attgttaata ttagacaaac agtagacaaa tgcagcagca agtcaattgt attagcagaa   1680

tattgtcctc attgcatgtg tagtttgagc acagatccca aaccttacgg ccaagtttct   1740

tctagtatga tggaaagttt cttttttctt tgctctgaat aaaactgaac tgtgggttct   1800

ctataagtgg cattttgggc tttccctctt ttttgtaaag caatgtctgc ctagtttatt   1860

gtccagttaa ctttagtgac cttttaaaag ttggcattgt aaataaaaca acttgcaaaa   1920

aagttttctg gaatagaatt aacaaaatat tatctttatt catgagttgg aaactggaaa   1980

aaggcttctt gaagtaaatg ttctgagtgg agctactagg atgtcttcca gcctcctgca   2040

gtcaaggagt accactgtat tgattagcct gtatgtagca gggctccctt cattgcatct   2100

gaggacttgt tttctttttc tttattttta atcctcttag ttttaaatat attgcctaga   2160

gactcagtta ctacccagtt tgtggttttt tgggagaaat gtaactggac agttagcttt   2220

tcaattaaaa agacacttaa cccatgtggg atgtcatctt tttataatta gtgttcccat   2280

gtggagaaaa ttattcacac tacttgcatg taaagaataa tttaactttt aacattaaaa   2340

tatgtggtaa aacccagaaa gcatccatca tgaatgcaag atactttcaa taaaaagtaa   2400

gttatatagt aggtagttaa gtttgctttt gtggacttaa atgtgtctct tcacttaaat   2460

gggttgaatg tgtatatatt tgttcagctt gaaaagactt agtttatatc ctagctcact   2520

ggaggctgct gacataacca taacttctgt cccttctaat tgtcatttat atgcctaact   2580

ggagctagta ctttaattct taacacaaaa ttactctgcc attgtttcca gcttccctcc   2640

tacaatagaa tgaagttttt ttgatggctt gagatggctc acaaattttg attttttttt   2700

cttccttgtg ctcccttttt ttctccttgc ttttccagtt aacatctata ttcacatgta   2760

atcttgtttt ctcttcacat tcactgagtt gttcaggctc agatcatccc ttgacagtag   2820

tttgccttca tctcaccttt catttgtccc aaattcacct tatttaataa agtcccatat   2880

gttgtctcac ttaa                                                     2894


<210>  2853
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  2853

Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95


Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp 
    130                 135                 140


Phe Thr Glu Glu Glu Glu Ala Gln Val Gly Ser Thr Gln Phe Cys Leu 
145                 150                 155                 160


<210>  2854
<211>  1881
<212>  DNA
<213>  Homo sapiens

<400>  2854
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa gatttgggaa    480

tggatgatga aggagatgat gacccagttc ctctaccaaa tgtgaatgca gcaatattaa    540

aaaaggtcat tcagtggtgc acccaccaca aggatgaccc tcctcctcct gaagatgatg    600

agaacaaaga aaagcgaaca gatgatatcc ctgtttggga ccaagaattc ctgaaagttg    660

accaaggaac actttttgaa ctcattctgg ctgcaaacta cttagacatc aaaggtttgc    720

ttgatgttac atgcaagact gttgccaata tgatcaaggg gaaaactcct gaggagattc    780

gcaagacctt caatatcaaa aatgagcttt ccctcttttt tgtaaagcaa tgtctgccta    840

gtttattgtc cagttaactt tagtgacctt ttaaaagttg gcattgtaaa taaaacaact    900

tgcaaaaaag ttttctggaa tagaattaac aaaatattat ctttattcat gagttggaaa    960

ctggaaaaag gcttcttgaa gtaaatgttc tgagtggagc tactaggatg tcttccagcc   1020

tcctgcagtc aaggagtacc actgtattga ttagcctgta tgtagcaggg ctcccttcat   1080

tgcatctgag gacttgtttt ctttttcttt atttttaatc ctcttagttt taaatatatt   1140

gcctagagac tcagttacta cccagtttgt ggttttttgg gagaaatgta actggacagt   1200

tagcttttca attaaaaaga cacttaaccc atgtgggatg tcatcttttt ataattagtg   1260

ttcccatgtg gagaaaatta ttcacactac ttgcatgtaa agaataattt aacttttaac   1320

attaaaatat gtggtaaaac ccagaaagca tccatcatga atgcaagata ctttcaataa   1380

aaagtaagtt atatagtagg tagttaagtt tgcttttgtg gacttaaatg tgtctcttca   1440

cttaaatggg ttgaatgtgt atatatttgt tcagcttgaa aagacttagt ttatatccta   1500

gctcactgga ggctgctgac ataaccataa cttctgtccc ttctaattgt catttatatg   1560

cctaactgga gctagtactt taattcttaa cacaaaatta ctctgccatt gtttccagct   1620

tccctcctac aatagaatga agtttttttg atggcttgag atggctcaca aattttgatt   1680

tttttttctt ccttgtgctc cctttttttc tccttgcttt tccagttaac atctatattc   1740

acatgtaatc ttgttttctc ttcacattca ctgagttgtt caggctcaga tcatcccttg   1800

acagtagttt gccttcatct cacctttcat ttgtcccaaa ttcaccttat ttaataaagt   1860

cccatatgtt gtctcactta a                                             1881


<210>  2855
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  2855

Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95


Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Glu 
    130                 135                 140


Leu Ser Leu Phe Phe Val Lys Gln Cys Leu Pro Ser Leu Leu Ser Ser 
145                 150                 155                 160


<210>  2856
<211>  2400
<212>  DNA
<213>  Homo sapiens

<400>  2856
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa gatttgggaa    480

tggatgatga aggagatgat gacccagttc ctctaccaaa tgtgaatgca gcaatattaa    540

aaaaggtcat tcagtggtgc acccaccaca aggatgaccc tcctcctcct gaagatgatg    600

agaacaaaga aaagcgaaca gatgatatcc ctgtttggga ccaagaattc ctgaaagttg    660

accaaggaac actttttgaa ctcattctgg ctgcaaacta cttagacatc aaaggtttgc    720

ttgatgttac atgcaagact gttgccaata tgatcaaggg gaaaactcct gaggagattc    780

gcaagacctt caatatcaaa aatgacttta ctgaagagga ggaagcccag cagggcagaa    840

taaaaaccat gggaggcaaa gaaaggaaat ccggaaatat agtcttaacc tggtgttgtt    900

ctaattttcc atctgttctt ctgactcaac tcactggcta tcgatgaatc agtaggtagt    960

atttataagt cttaggaaag actactcaag ttaaggtact tccctatatc catctctttt   1020

aggtacgcaa agagaaccag tggtgtgaag agaagtgaaa tgttgtgcct gacactgtaa   1080

cactgtaagg attgttccaa atactagttg cactgctctg tttataattg ttaatattag   1140

acaaacagta gacaaatgca gcagcaagtc aattgtatta gcagaatatt gtcctcattg   1200

catgtgtagt ttgagcacag atcccaaacc ttacggccaa gtttcttcta gtatgatgga   1260

aagtttcttt tttctttgct ctgaataaaa ctgaactgtg ggttctctat aagtggcatt   1320

ttgggctttc cctctttttt gtaaagcaat gtctgcctag tttattgtcc agttaacttt   1380

agtgaccttt taaaagttgg cattgtaaat aaaacaactt gcaaaaaagt tttctggaat   1440

agaattaaca aaatattatc tttattcatg agttggaaac tggaaaaagg cttcttgaag   1500

taaatgttct gagtggagct actaggatgt cttccagcct cctgcagtca aggagtacca   1560

ctgtattgat tagcctgtat gtagcagggc tcccttcatt gcatctgagg acttgttttc   1620

tttttcttta tttttaatcc tcttagtttt aaatatattg cctagagact cagttactac   1680

ccagtttgtg gttttttggg agaaatgtaa ctggacagtt agcttttcaa ttaaaaagac   1740

acttaaccca tgtgggatgt catcttttta taattagtgt tcccatgtgg agaaaattat   1800

tcacactact tgcatgtaaa gaataattta acttttaaca ttaaaatatg tggtaaaacc   1860

cagaaagcat ccatcatgaa tgcaagatac tttcaataaa aagtaagtta tatagtaggt   1920

agttaagttt gcttttgtgg acttaaatgt gtctcttcac ttaaatgggt tgaatgtgta   1980

tatatttgtt cagcttgaaa agacttagtt tatatcctag ctcactggag gctgctgaca   2040

taaccataac ttctgtccct tctaattgtc atttatatgc ctaactggag ctagtacttt   2100

aattcttaac acaaaattac tctgccattg tttccagctt ccctcctaca atagaatgaa   2160

gtttttttga tggcttgaga tggctcacaa attttgattt ttttttcttc cttgtgctcc   2220

ctttttttct ccttgctttt ccagttaaca tctatattca catgtaatct tgttttctct   2280

tcacattcac tgagttgttc aggctcagat catcccttga cagtagtttg ccttcatctc   2340

acctttcatt tgtcccaaat tcaccttatt taataaagtc ccatatgttg tctcacttaa   2400


<210>  2857
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  2857

Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95


Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp 
    130                 135                 140


Phe Thr Glu Glu Glu Glu Ala Gln Gln Gly Arg Ile Lys Thr Met Gly 
145                 150                 155                 160


Gly Lys Glu Arg Lys Ser Gly Asn Ile Val Leu Thr Trp Cys Cys Ser 
                165                 170                 175


Asn Phe Pro Ser Val Leu Leu Thr Gln Leu Thr Gly Tyr Arg 
            180                 185                 190


<210>  2858
<211>  2296
<212>  DNA
<213>  Homo sapiens

<400>  2858
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa gtcactgttc    480

atcaagtacc tattgaatga agagtatgtt gtgctcacta aaaaaaactg aaagcaatcc    540

aagtgtccct aaaaggcaga tttgggaatg gatgatgaag gagatgatga cccagttcct    600

ctaccaaatg tgaatgcagc aatattaaaa aaggtcattc agtggtgcac ccaccacaag    660

gatgaccctc ctcctcctga agatgatgag aacaaagaaa agcgaacaga tgatatccct    720

gtttgggacc aagaattcct gaaagttgac caaggaacac tttttgaact cattctggct    780

gcaaactact tagacatcaa aggtttgctt gatgttacat gcaagactgt tgccaatatg    840

atcaagggga aaactcctga ggagattcgc aagaccttca atatcaaaaa tgactttact    900

gaagaggagg aagcccaggt acgcaaagag aaccagtggt gtgaagagaa gtgaaatgtt    960

gtgcctgaca ctgtaacact gtaaggattg ttccaaatac tagttgcact gctctgttta   1020

taattgttaa tattagacaa acagtagaca aatgcagcag caagtcaatt gtattagcag   1080

aatattgtcc tcattgcatg tgtagtttga gcacagatcc caaaccttac ggccaagttt   1140

cttctagtat gatggaaagt ttcttttttc tttgctctga ataaaactga actgtgggtt   1200

ctctataagt ggcattttgg gctttccctc ttttttgtaa agcaatgtct gcctagttta   1260

ttgtccagtt aactttagtg accttttaaa agttggcatt gtaaataaaa caacttgcaa   1320

aaaagttttc tggaatagaa ttaacaaaat attatcttta ttcatgagtt ggaaactgga   1380

aaaaggcttc ttgaagtaaa tgttctgagt ggagctacta ggatgtcttc cagcctcctg   1440

cagtcaagga gtaccactgt attgattagc ctgtatgtag cagggctccc ttcattgcat   1500

ctgaggactt gttttctttt tctttatttt taatcctctt agttttaaat atattgccta   1560

gagactcagt tactacccag tttgtggttt tttgggagaa atgtaactgg acagttagct   1620

tttcaattaa aaagacactt aacccatgtg ggatgtcatc tttttataat tagtgttccc   1680

atgtggagaa aattattcac actacttgca tgtaaagaat aatttaactt ttaacattaa   1740

aatatgtggt aaaacccaga aagcatccat catgaatgca agatactttc aataaaaagt   1800

aagttatata gtaggtagtt aagtttgctt ttgtggactt aaatgtgtct cttcacttaa   1860

atgggttgaa tgtgtatata tttgttcagc ttgaaaagac ttagtttata tcctagctca   1920

ctggaggctg ctgacataac cataacttct gtcccttcta attgtcattt atatgcctaa   1980

ctggagctag tactttaatt cttaacacaa aattactctg ccattgtttc cagcttccct   2040

cctacaatag aatgaagttt ttttgatggc ttgagatggc tcacaaattt tgattttttt   2100

ttcttccttg tgctcccttt ttttctcctt gcttttccag ttaacatcta tattcacatg   2160

taatcttgtt ttctcttcac attcactgag ttgttcaggc tcagatcatc ccttgacagt   2220

agtttgcctt catctcacct ttcatttgtc ccaaattcac cttatttaat aaagtcccat   2280

atgttgtctc acttaa                                                   2296


<210>  2859
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  2859

Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro Asn Val Asn 
1               5                   10                  15


Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His His Lys Asp 
            20                  25                  30


Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys Arg Thr Asp 
        35                  40                  45


Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp Gln Gly Thr 
    50                  55                  60


Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile Lys Gly Leu 
65                  70                  75                  80


Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys Gly Lys Thr 
                85                  90                  95


Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp Phe Thr Glu 
            100                 105                 110


Glu Glu Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys Glu Glu Lys 
        115                 120                 125


<210>  2860
<211>  2261
<212>  DNA
<213>  Homo sapiens

<400>  2860
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccacataa atgagcatat tctgatgtac tctttggatc tgaactcatc    420

ttcacagatg ccttcaatta agttgcagag ttctgatgga gagatatttg aagttgatgt    480

ggaaattgcc aaacaatctg tgactattaa gaccatgttg gaagatttgg gaatggatga    540

tgaaggagat gatgacccag ttcctctacc aaatgtgaat gcagcaatat taaaaaaggt    600

cattcagtgg tgcacccacc acaaggatga ccctcctcct cctgaagatg atgagaacaa    660

agaaaagcga acagatgata tccctgtttg ggaccaagaa ttcctgaaag ttgaccaagg    720

aacacttttt gaactcattc tggctgcaaa ctacttagac atcaaaggtt tgcttgatgt    780

tacatgcaag actgttgcca atatgatcaa ggggaaaact cctgaggaga ttcgcaagac    840

cttcaatatc aaaaatgact ttactgaaga ggaggaagcc caggtacgca aagagaacca    900

gtggtgtgaa gagaagtgaa atgttgtgcc tgacactgta acactgtaag gattgttcca    960

aatactagtt gcactgctct gtttataatt gttaatatta gacaaacagt agacaaatgc   1020

agcagcaagt caattgtatt agcagaatat tgtcctcatt gcatgtgtag tttgagcaca   1080

gatcccaaac cttacggcca agtttcttct agtatgatgg aaagtttctt ttttctttgc   1140

tctgaataaa actgaactgt gggttctcta taagtggcat tttgggcttt ccctcttttt   1200

tgtaaagcaa tgtctgccta gtttattgtc cagttaactt tagtgacctt ttaaaagttg   1260

gcattgtaaa taaaacaact tgcaaaaaag ttttctggaa tagaattaac aaaatattat   1320

ctttattcat gagttggaaa ctggaaaaag gcttcttgaa gtaaatgttc tgagtggagc   1380

tactaggatg tcttccagcc tcctgcagtc aaggagtacc actgtattga ttagcctgta   1440

tgtagcaggg ctcccttcat tgcatctgag gacttgtttt ctttttcttt atttttaatc   1500

ctcttagttt taaatatatt gcctagagac tcagttacta cccagtttgt ggttttttgg   1560

gagaaatgta actggacagt tagcttttca attaaaaaga cacttaaccc atgtgggatg   1620

tcatcttttt ataattagtg ttcccatgtg gagaaaatta ttcacactac ttgcatgtaa   1680

agaataattt aacttttaac attaaaatat gtggtaaaac ccagaaagca tccatcatga   1740

atgcaagata ctttcaataa aaagtaagtt atatagtagg tagttaagtt tgcttttgtg   1800

gacttaaatg tgtctcttca cttaaatggg ttgaatgtgt atatatttgt tcagcttgaa   1860

aagacttagt ttatatccta gctcactgga ggctgctgac ataaccataa cttctgtccc   1920

ttctaattgt catttatatg cctaactgga gctagtactt taattcttaa cacaaaatta   1980

ctctgccatt gtttccagct tccctcctac aatagaatga agtttttttg atggcttgag   2040

atggctcaca aattttgatt tttttttctt ccttgtgctc cctttttttc tccttgcttt   2100

tccagttaac atctatattc acatgtaatc ttgttttctc ttcacattca ctgagttgtt   2160

caggctcaga tcatcccttg acagtagttt gccttcatct cacctttcat ttgtcccaaa   2220

ttcaccttat ttaataaagt cccatatgtt gtctcactta a                       2261


<210>  2861
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  2861

Met Tyr Ser Leu Asp Leu Asn Ser Ser Ser Gln Met Pro Ser Ile Lys 
1               5                   10                  15


Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val Asp Val Glu Ile Ala 
            20                  25                  30


Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu Asp Leu Gly Met Asp 
        35                  40                  45


Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro Asn Val Asn Ala Ala 
    50                  55                  60


Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His His Lys Asp Asp Pro 
65                  70                  75                  80


Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys Arg Thr Asp Asp Ile 
                85                  90                  95


Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp Gln Gly Thr Leu Phe 
            100                 105                 110


Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile Lys Gly Leu Leu Asp 
        115                 120                 125


Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys Gly Lys Thr Pro Glu 
    130                 135                 140


Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp Phe Thr Glu Glu Glu 
145                 150                 155                 160


Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys Glu Glu Lys 
                165                 170


<210>  2862
<211>  892
<212>  DNA
<213>  Homo sapiens

<400>  2862
ggctgcaaac tacttagaca tcaaaggttt gcttgatgtt acatgcaaga ctgttgccaa     60

tatgatcaag gggaaaactc ctgaggagat tcgcaagacc ttcaatatca aaaatgactt    120

tactgaagag gaggaagccc aggtacgcaa agagaaccag tggtgtgaag agaagtgaaa    180

ttttgagcac agatcccaaa ccttacggcc aagtttcttc tagtatgatg gaaagtttct    240

tttttctttg ctctgaataa aactgaactg tgggttctct ataagtggca ttttgggctt    300

tccctctttt ttgtaaagca atgtctgcct agtttattgt ccagttaact ttagtgacct    360

tttaaaagtt ggcattgtaa ataaaacaac ttgcaaaaaa gttttctgga atagaattaa    420

caaaatatta tctttattca tgagttggaa actggaaaaa ggcttcttga agtaaatgtt    480

ctgagtggag ctactaggat gtcttccagc ctcctgcagt caaggagtac cactgtattg    540

attagcctgt atgtagcagg gctcccttca ttgcatctga ggacttgttt tctttttctt    600

tatttttaat cctcttagtt ttaaatatat tgcctagaga ctcagttact acccagtttg    660

tggttttttg ggagaaatgt aactggacag ttagcttttc aattaaaaag acacttaacc    720

catgtgggat gtcatctttt tataattagt gttcccatgt ggagaaaatt attcacacta    780

cttgcatgta aagaataatt taacttttaa cattaaaata tgtggtaaaa cccagaaagc    840

atccatcatg aatgcaagat actttcaata aaaagtaagt tatatagtag gt            892


<210>  2863
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  2863

Met Thr Leu Leu Lys Arg Arg Lys Pro Arg Tyr Ala Lys Arg Thr Ser 
1               5                   10                  15


Gly Val Lys Arg Ser Glu Ile Leu Ser Thr Asp Pro Lys Pro Tyr Gly 
            20                  25                  30


Gln Val Ser Ser Ser Met Met Glu Ser Phe Phe Phe Leu Cys Ser Glu 
        35                  40                  45


<210>  2864
<211>  3149
<212>  DNA
<213>  Homo sapiens

<400>  2864
aaaacaaaaa cctttcgctg gccaggcaca gtggctcata gctgtaatcc caacactttg     60

ggagggcaag gtgggtgaat tgcttgagtt caggagtttg caacatgatg aaaccttatc    120

tctacaaaaa caaaatacaa aaatgagcca ggtgtggtgg catgcacctg tagttgcagc    180

tacttgggag gctgaggtgg gaggatcgct taagcacagg aggtcgagtg agccatgatc    240

gcggcactgc attccagcct gggtgacaca gtgagatctt gtctcaaaaa caaacaaaca    300

accctttgct tggcttttcc ttattgaaat tgttctttct tttttttttt ttggatcctg    360

gcaatgtttc ttggctctgc cattttctct cagcattgtt tactcctcca acattttgct    420

atgaaaaagt tttagccata cagaaaaatg gaaagaatta cacagtagac aaccatgtag    480

ccactgccta gattctacaa ctgaaaacac tttcagtatt gattttggtc tttatgctgg    540

tatgtatagt ctaagtaatc agcttcctga aactttatgg agtaattatt ctcctattaa    600

ggaaattttg gggcttttcc tgctttgttc ctacaccaaa tagtctcaca catgtgtcta    660

gggtatttgg aatttgctgg ttacaatata tgtacatatt cagcttttct gaggagtgct    720

ggattagctt tcaaaggggt tataccaatt tatactctct agaagagttt gtgtttcctt    780

tccactattg cccaacaatt agtatcagtt tcttgatttt ttttcaatct agagaagtat    840

ctgtagtgtt agttttgctt ctagtaaagt tgagcgttcc ttatgtttgg ctattcagat    900

ttcatttatt ggctgtacat attaacccat ttctctttaa tgatttttga aagattttat    960

attctctcag ctaatcattg ttgtacatat tgcaggtatc ttccagtcat tgtcctaact   1020

tttctttttg catagaagct ttttaatgta gtcaagtaca gtactctgtc tgcatggctt   1080

gcttttatct aataagatct tctcccttct agggttataa tgattcttca agcttcattt   1140

ttgtttttca agcttggctg ttaatggctc aagtcaacct ctagctagtt attattccaa   1200

tatagggata agttgtccca gcagtggaat gagtaccttg tgacaaagtg ccacagagga   1260

atgaactttt gttgttgtag gtcattcagt ggtgcaccca ccacaaggat gaccctcctc   1320

ctcctgaaga tgatgagaac aaagaaaagc gaacagatga tatccctgtt tgggaccaag   1380

aattcctgaa agttgaccaa ggaacacttt ttgaactcat tctggctgca aactacttag   1440

acatcaaagg tttgcttgat gttacatgca agactgttgc caatatgatc aaggggaaaa   1500

ctcctgagga gattcgcaag accttcaata tcaaaaatga ctttactgaa gaggaggaag   1560

cccaggtagg tagcacacag ttttgtcttt gatcacatgc tcttaaaaag ggagtaacac   1620

ctataacatg ccagcaaaag aggtgactgt atcaagtagt cttgatactt tagggataat   1680

atgtacttaa tgtgtcttaa acatactctt actgttctgt ctttatgaat ctgaacactt   1740

agatgatact gcattttaag cataagaaca attagttttc aatgagaaga gctcttgtta   1800

atgtattaac agttactagt tttggcacct gcaactttct gtatagacca tacatatctg   1860

acatcagaaa agcaggccct agagagaagt atatactagg gtactttaga gcaacttaat   1920

gaggggagga aatgaaagaa tagatcagaa tgattttgtt gacatgacta cagactgaaa   1980

taatgtgaat gaattaactg aatttgctct gtcaacttta gtaaattgcc cattgccttt   2040

gctttgttca taatttcagc agggcagaat aaaaaccatg ggaggcaaag aaaggaaatc   2100

cggaaatata gtcttaacct ggtgttgttc taattttcca tctgttcttc tgactcaact   2160

cactggctat cgatgaatca gtaggtagta tttataagtc ttaggaaaga ctactcaagt   2220

taaggtactt ccctatatcc atctctttta ggtacgcaaa gagaaccagt ggtgtgaaga   2280

gaagtgaaat gttgtgcctg acactgtaac actgtaagga ttgttccaaa tactagttgc   2340

actgctctgt ttataattgt taatattaga caaacagtag acaaatgcag cagcaagtca   2400

attgtattag cagaatattg tcctcattgc atgtgtagtt tgagcacaga tcccaaacct   2460

tacggccaag tttcttctag tatgatggaa agtttctttt ttctttgctc tgaataaaac   2520

tgaactgtgg gttctctata agtggcattt tgggctttcc ctcttttttg taaagcaatg   2580

tctgcctagt ttattgtcca gttaacttta gtgacctttt aaaagttggc attgtaaata   2640

aaacaacttg caaaaaagtt ttctggaata gaattaacaa aatattatct ttattcatga   2700

gttggaaact ggaaaaaggc ttcttgaagt aaatgttctg agtggagcta ctaggatgtc   2760

ttccagcctc ctgcagtcaa ggagtaccac tgtattgatt agcctgtatg tagcagggct   2820

cccttcattg catctgagga cttgttttct ttttctttat ttttaatcct cttagtttta   2880

aatatattgc ctagagactc agttactacc cagtttgtgg ttttttggga gaaatgtaac   2940

tggacagtta gcttttcaat taaaaagaca cttaacccat gtgggatgtc atctttttat   3000

aattagtgtt cccatgtgga gaaaattatt cacactactt gcatgtaaag aataatttaa   3060

cttttaacat taaaatatgt ggtaaaaccc agaaagcatc catcatgaat gcaagatact   3120

ttcaataaaa agtaagttat atagtaggt                                     3149


<210>  2865
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  2865

Met Tyr Ile Phe Ser Phe Ser Glu Glu Cys Trp Ile Ser Phe Gln Arg 
1               5                   10                  15


Gly Tyr Thr Asn Leu Tyr Ser Leu Glu Glu Phe Val Phe Pro Phe His 
            20                  25                  30


Tyr Cys Pro Thr Ile Ser Ile Ser Phe Leu Ile Phe Phe Gln Ser Arg 
        35                  40                  45


Glu Val Ser Val Val Leu Val Leu Leu Leu Val Lys Leu Ser Val Pro 
    50                  55                  60


Tyr Val Trp Leu Phe Arg Phe His Leu Leu Ala Val His Ile Asn Pro 
65                  70                  75                  80


Phe Leu Phe Asn Asp Phe 
                85


<210>  2866
<211>  1513
<212>  DNA
<213>  Homo sapiens

<400>  2866
gttgtcgacc ctgttcttcg ggagacccta ccaggttccg ttcacctgcc ccgcccccga     60

ctcagcgagg cctcctctgg ccgggcgtcc tcacggcgct ccataaacat aaatgagcat    120

attctgatgt actctttgga tctgaactca tcttcacaga tgccttcaat taagttgcag    180

agttctgatg gagagatatt tgaagttgat gtggaaattg ccaaacaatc tgtgactatt    240

aagaccatgt tggaagattt gggaatggat gatgaaggag atgatgaccc agttcctcta    300

ccaaatgtga atgcagcaat attaaaaaag gtcattcagt ggtgcaccca ccacaaggat    360

gaccctcctc ctcctgaaga tgatgagaac aaagaaaagc gaacagatga tatccctgtt    420

tgggaccaag aattcctgaa agttgaccaa ggaacacttt ttgaactcat tctggctgca    480

aactacttag acatcaaagg tttgcttgat gttacatgca agactgttgc caatatgatc    540

aaggggaaaa ctcctgagga gattcgcaag accttcaata tcaaaaatga ctttactgaa    600

gaggaggaag cccaggtacg caaagagaac cagtggtgtg aagagaagtg aaatgttgtg    660

cctgacactg taacactgta aggattgttc caaatactag ttgcactgct ctgtttataa    720

ttgttaatat tagacaaaca gtagacaaat gcagcagcaa gtcaattgta ttagcagaat    780

attgtcctca ttgcatgtgt agtttgagca cagatcccaa accttacggc caagtttctt    840

ctagtatgat ggaaagtttc ttttttcttt gctctgaata aaactgaact gtgggttctc    900

tataagtggc attttgggct ttccctcttt tttgtaaagc aatgtctgcc tagtttattg    960

tccagttaac tttagtgacc ttttaaaagt tggcattgta aataaaacaa cttgcaaaaa   1020

agttttctgg aatagaatta acaaaatatt atctttattc atgagttgga aactggaaaa   1080

aggcttcttg aagtaaatgt tctgagtgga gctactagga tgtcttccag cctcctgcag   1140

tcaaggagta ccactgtatt gattagcctg tatgtagcag ggctcccttc attgcatctg   1200

aggacttgtt ttctttttct ttatttttaa tcctcttagt tttaaatata ttgcctagag   1260

actcagttac tacccagttt gtggtttttt gggagaaatg taactggaca gttagctttt   1320

caattaaaaa gacacttaac ccatgtggga tgtcatcttt ttataattag tgttcccatg   1380

tggagaaaat tattcacact acttgcatgt aaagaataat ttaactttta acattaaaat   1440

atgtggtaaa acccagaaag catccatcat gaatgcaaga tactttcaat aaaaagtaag   1500

ttatatagta ggt                                                      1513


<210>  2867
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  2867

Met Tyr Ser Leu Asp Leu Asn Ser Ser Ser Gln Met Pro Ser Ile Lys 
1               5                   10                  15


Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val Asp Val Glu Ile Ala 
            20                  25                  30


Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu Asp Leu Gly Met Asp 
        35                  40                  45


Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro Asn Val Asn Ala Ala 
    50                  55                  60


Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His His Lys Asp Asp Pro 
65                  70                  75                  80


Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys Arg Thr Asp Asp Ile 
                85                  90                  95


Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp Gln Gly Thr Leu Phe 
            100                 105                 110


Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile Lys Gly Leu Leu Asp 
        115                 120                 125


Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys Gly Lys Thr Pro Glu 
    130                 135                 140


Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp Phe Thr Glu Glu Glu 
145                 150                 155                 160


Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys Glu Glu Lys 
                165                 170


<210>  2868
<211>  1781
<212>  DNA
<213>  Homo sapiens

<400>  2868
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccacataa atgagcatat tctgatgtac tctttggatc tgaactcatc    420

ttcacagatg ccttcaatta agttgcagag ttctgatgga gagatatttg aagttgatgt    480

ggaaattgcc aaacaatctg tgactattaa gaccatgttg gaagatttgg gaatggatga    540

tgaaggagat gatgacccag ttcctctacc aaatgtgaat gcagcaatat taaaaaaggt    600

cattcagtgg tgcacccacc acaaggatga ccctcctcct cctgaagatg atgagaacaa    660

agaaaagcga acagatgata tccctgtttg ggaccaagaa ttcctgaaag ttgaccaagg    720

aacacttttt gaactcattc tggctgcaaa ctacttagac atcaaaggtt tgcttgatgt    780

tacatgcaag actgttgcca atatgatcaa ggggaaaact cctgaggaga ttcgcaagac    840

cttcaatatc aaaaatgact ttactgaaga ggaggaagcc caggtacgca aagagaacca    900

gtggtgtgaa gagaagtgaa atgttgtgcc tgacactgta acactgtaag gattgttcca    960

aatactagtt gcactgctct gtttataatt gttaatatta gacaaacagt agacaaatgc   1020

agcagcaagt caattgtatt agcagaatat tgtcctcatt gcatgtgtag tttgagcaca   1080

gatcccaaac cttacggcca agtttcttct agtatgatgg aaagtttctt ttttctttgc   1140

tctgaataaa actgaactgt gggttctcta taagtggcat tttgggcttt ccctcttttt   1200

tgtaaagcaa tgtctgccta gtttattgtc cagttaactt tagtgacctt ttaaaagttg   1260

gcattgtaaa taaaacaact tgcaaaaaag ttttctggaa tagaattaac aaaatattat   1320

ctttattcat gagttggaaa ctggaaaaag gcttcttgaa gtaaatgttc tgagtggagc   1380

tactaggatg tcttccagcc tcctgcagtc aaggagtacc actgtattga ttagcctgta   1440

tgtagcaggg ctcccttcat tgcatctgag gacttgtttt ctttttcttt atttttaatc   1500

ctcttagttt taaatatatt gcctagagac tcagttacta cccagtttgt ggttttttgg   1560

gagaaatgta actggacagt tagcttttca attaaaaaga cacttaaccc atgtgggatg   1620

tcatcttttt ataattagtg ttcccatgtg gagaaaatta ttcacactac ttgcatgtaa   1680

agaataattt aacttttaac attaaaatat gtggtaaaac ccagaaagca tccatcatga   1740

atgcaagata ctttcaataa aaagtaagtt atatagtagg t                       1781


<210>  2869
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  2869

Met Tyr Ser Leu Asp Leu Asn Ser Ser Ser Gln Met Pro Ser Ile Lys 
1               5                   10                  15


Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val Asp Val Glu Ile Ala 
            20                  25                  30


Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu Asp Leu Gly Met Asp 
        35                  40                  45


Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro Asn Val Asn Ala Ala 
    50                  55                  60


Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His His Lys Asp Asp Pro 
65                  70                  75                  80


Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys Arg Thr Asp Asp Ile 
                85                  90                  95


Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp Gln Gly Thr Leu Phe 
            100                 105                 110


Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile Lys Gly Leu Leu Asp 
        115                 120                 125


Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys Gly Lys Thr Pro Glu 
    130                 135                 140


Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp Phe Thr Glu Glu Glu 
145                 150                 155                 160


Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys Glu Glu Lys 
                165                 170


<210>  2870
<211>  2414
<212>  DNA
<213>  Homo sapiens

<400>  2870
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa gatttgggaa    480

tggatgatga aggagatgat gacccagttc ctctaccaaa tgtgaatgca gcaatattaa    540

aaaaggtcat tcagtggtgc acccaccaca aggatgaccc tcctcctcct gaagatgatg    600

agaacaaaga aaagcgaaca gatgatatcc ctgtttggga ccaagaattc ctgaaagttg    660

accaaggaac actttttgaa ctcattctgg ctgcaaacta cttagacatc aaaggtttgc    720

ttgatgttac atgcaagact gttgccaata tgatcaaggg gaaaactcct gaggagattc    780

gcaagacctt caatatcaaa aatgacttta ctgaagagga ggaagcccag gtaggtagca    840

cacagttttg tctttgatca catgctctta aaaagggagt aacacctata acatgccagc    900

aaaagaggtg actgtatcaa gtagtcttga tactttaggg ataatatgta cttaatgtgt    960

cttaaacata ctcttactgt tctgtcttta tgaatctgaa cacttagatg atactgcatt   1020

ttaagcataa gaacaattag ttttcaatga gaagagctct tgttaatgta ttaacagtta   1080

ctagttttgg cacctgcaac tttctgtata gaccatacat atctgacatc agaaaagcag   1140

gccctagaga gaagtatata ctagggtact ttagagcaac ttaatgaggg gaggaaatga   1200

aagaatagat cagaatgatt ttgttgacat gactacagac tgaaataatg tgaatgaatt   1260

aactgaattt gctctgtcaa ctttagtaaa ttgcccattg cctttgcttt gttcataatt   1320

tcagcagggc agaataaaaa ccatgggagg caaagaaagg aaatccggaa atatagtctt   1380

aacctggtgt tgttctaatt ttccatctgt tcttctgact caactcactg gctatcgatg   1440

aatcagtagg tagtatttat aagtcttagg aaagactact caagttaagg tacttcccta   1500

tatccatctc ttttaggtac gcaaagagaa ccagtggtgt gaagagaagt gaaatgttgt   1560

gcctgacact gtaacactgt aaggattgtt ccaaatacta gttgcactgc tctgtttata   1620

attgttaata ttagacaaac agtagacaaa tgcagcagca agtcaattgt attagcagaa   1680

tattgtcctc attgcatgtg tagtttgagc acagatccca aaccttacgg ccaagtttct   1740

tctagtatga tggaaagttt cttttttctt tgctctgaat aaaactgaac tgtgggttct   1800

ctataagtgg cattttgggc tttccctctt ttttgtaaag caatgtctgc ctagtttatt   1860

gtccagttaa ctttagtgac cttttaaaag ttggcattgt aaataaaaca acttgcaaaa   1920

aagttttctg gaatagaatt aacaaaatat tatctttatt catgagttgg aaactggaaa   1980

aaggcttctt gaagtaaatg ttctgagtgg agctactagg atgtcttcca gcctcctgca   2040

gtcaaggagt accactgtat tgattagcct gtatgtagca gggctccctt cattgcatct   2100

gaggacttgt tttctttttc tttattttta atcctcttag ttttaaatat attgcctaga   2160

gactcagtta ctacccagtt tgtggttttt tgggagaaat gtaactggac agttagcttt   2220

tcaattaaaa agacacttaa cccatgtggg atgtcatctt tttataatta gtgttcccat   2280

gtggagaaaa ttattcacac tacttgcatg taaagaataa tttaactttt aacattaaaa   2340

tatgtggtaa aacccagaaa gcatccatca tgaatgcaag atactttcaa taaaaagtaa   2400

gttatatagt aggt                                                     2414


<210>  2871
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  2871

Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95


Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp 
    130                 135                 140


Phe Thr Glu Glu Glu Glu Ala Gln Val Gly Ser Thr Gln Phe Cys Leu 
145                 150                 155                 160


<210>  2872
<211>  1728
<212>  DNA
<213>  Homo sapiens

<400>  2872
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa gatttgggaa    480

tggatgatga aggagatgat gacccagttc ctctaccaaa tgtgaatgca gcaatattaa    540

aaaaggtcat tcagtggtgc acccaccaca aggatgaccc tcctcctcct gaagatgatg    600

agaacaaaga aaagcgaaca gatgatatcc ctgtttggga ccaagaattc ctgaaagttg    660

accaaggaac actttttgaa ctcattctgg ctgcaaacta cttagacatc aaaggtttgc    720

ttgatgttac atgcaagact gttgccaata tgatcaaggg gaaaactcct gaggagattc    780

gcaagacctt caatatcaaa aatgacttta ctgaagagga ggaagcccag gtacgcaaag    840

agaaccagtg gtgtgaagag aagtgaaatg ttgtgcctga cactgtaaca ctgtaaggat    900

tgttccaaat actagttgca ctgctctgtt tataattgtt aatattagac aaacagtaga    960

caaatgcagc agcaagtcaa ttgtattagc agaatattgt cctcattgca tgtgtagttt   1020

gagcacagat cccaaacctt acggccaagt ttcttctagt atgatggaaa gtttcttttt   1080

tctttgctct gaataaaact gaactgtggg ttctctataa gtggcatttt gggctttccc   1140

tcttttttgt aaagcaatgt ctgcctagtt tattgtccag ttaactttag tgacctttta   1200

aaagttggca ttgtaaataa aacaacttgc aaaaaagttt tctggaatag aattaacaaa   1260

atattatctt tattcatgag ttggaaactg gaaaaaggct tcttgaagta aatgttctga   1320

gtggagctac taggatgtct tccagcctcc tgcagtcaag gagtaccact gtattgatta   1380

gcctgtatgt agcagggctc ccttcattgc atctgaggac ttgttttctt tttctttatt   1440

tttaatcctc ttagttttaa atatattgcc tagagactca gttactaccc agtttgtggt   1500

tttttgggag aaatgtaact ggacagttag cttttcaatt aaaaagacac ttaacccatg   1560

tgggatgtca tctttttata attagtgttc ccatgtggag aaaattattc acactacttg   1620

catgtaaaga ataatttaac ttttaacatt aaaatatgtg gtaaaaccca gaaagcatcc   1680

atcatgaatg caagatactt tcaataaaaa gtaagttata tagtaggt                1728


<210>  2873
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  2873

Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95


Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp 
    130                 135                 140


Phe Thr Glu Glu Glu Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys 
145                 150                 155                 160


Glu Glu Lys 



<210>  2874
<211>  1401
<212>  DNA
<213>  Homo sapiens

<400>  2874
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa gatttgggaa    480

tggatgatga aggagatgat gacccagttc ctctaccaaa tgtgaatgca gcaatattaa    540

aaaaggtcat tcagtggtgc acccaccaca aggatgaccc tcctcctcct gaagatgatg    600

agaacaaaga aaagcgaaca gatgatatcc ctgtttggga ccaagaattc ctgaaagttg    660

accaaggaac actttttgaa ctcattctgg ctgcaaacta cttagacatc aaaggtttgc    720

ttgatgttac atgcaagact gttgccaata tgatcaaggg gaaaactcct gaggagattc    780

gcaagacctt caatatcaaa aatgagcttt ccctcttttt tgtaaagcaa tgtctgccta    840

gtttattgtc cagttaactt tagtgacctt ttaaaagttg gcattgtaaa taaaacaact    900

tgcaaaaaag ttttctggaa tagaattaac aaaatattat ctttattcat gagttggaaa    960

ctggaaaaag gcttcttgaa gtaaatgttc tgagtggagc tactaggatg tcttccagcc   1020

tcctgcagtc aaggagtacc actgtattga ttagcctgta tgtagcaggg ctcccttcat   1080

tgcatctgag gacttgtttt ctttttcttt atttttaatc ctcttagttt taaatatatt   1140

gcctagagac tcagttacta cccagtttgt ggttttttgg gagaaatgta actggacagt   1200

tagcttttca attaaaaaga cacttaaccc atgtgggatg tcatcttttt ataattagtg   1260

ttcccatgtg gagaaaatta ttcacactac ttgcatgtaa agaataattt aacttttaac   1320

attaaaatat gtggtaaaac ccagaaagca tccatcatga atgcaagata ctttcaataa   1380

aaagtaagtt atatagtagg t                                             1401


<210>  2875
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  2875

Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95


Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Glu 
    130                 135                 140


Leu Ser Leu Phe Phe Val Lys Gln Cys Leu Pro Ser Leu Leu Ser Ser 
145                 150                 155                 160


<210>  2876
<211>  1816
<212>  DNA
<213>  Homo sapiens

<400>  2876
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa gtcactgttc    480

atcaagtacc tattgaatga agagtatgtt gtgctcacta aaaaaaactg aaagcaatcc    540

aagtgtccct aaaaggcaga tttgggaatg gatgatgaag gagatgatga cccagttcct    600

ctaccaaatg tgaatgcagc aatattaaaa aaggtcattc agtggtgcac ccaccacaag    660

gatgaccctc ctcctcctga agatgatgag aacaaagaaa agcgaacaga tgatatccct    720

gtttgggacc aagaattcct gaaagttgac caaggaacac tttttgaact cattctggct    780

gcaaactact tagacatcaa aggtttgctt gatgttacat gcaagactgt tgccaatatg    840

atcaagggga aaactcctga ggagattcgc aagaccttca atatcaaaaa tgactttact    900

gaagaggagg aagcccaggt acgcaaagag aaccagtggt gtgaagagaa gtgaaatgtt    960

gtgcctgaca ctgtaacact gtaaggattg ttccaaatac tagttgcact gctctgttta   1020

taattgttaa tattagacaa acagtagaca aatgcagcag caagtcaatt gtattagcag   1080

aatattgtcc tcattgcatg tgtagtttga gcacagatcc caaaccttac ggccaagttt   1140

cttctagtat gatggaaagt ttcttttttc tttgctctga ataaaactga actgtgggtt   1200

ctctataagt ggcattttgg gctttccctc ttttttgtaa agcaatgtct gcctagttta   1260

ttgtccagtt aactttagtg accttttaaa agttggcatt gtaaataaaa caacttgcaa   1320

aaaagttttc tggaatagaa ttaacaaaat attatcttta ttcatgagtt ggaaactgga   1380

aaaaggcttc ttgaagtaaa tgttctgagt ggagctacta ggatgtcttc cagcctcctg   1440

cagtcaagga gtaccactgt attgattagc ctgtatgtag cagggctccc ttcattgcat   1500

ctgaggactt gttttctttt tctttatttt taatcctctt agttttaaat atattgccta   1560

gagactcagt tactacccag tttgtggttt tttgggagaa atgtaactgg acagttagct   1620

tttcaattaa aaagacactt aacccatgtg ggatgtcatc tttttataat tagtgttccc   1680

atgtggagaa aattattcac actacttgca tgtaaagaat aatttaactt ttaacattaa   1740

aatatgtggt aaaacccaga aagcatccat catgaatgca agatactttc aataaaaagt   1800

aagttatata gtaggt                                                   1816


<210>  2877
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  2877

Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro Asn Val Asn 
1               5                   10                  15


Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His His Lys Asp 
            20                  25                  30


Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys Arg Thr Asp 
        35                  40                  45


Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp Gln Gly Thr 
    50                  55                  60


Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile Lys Gly Leu 
65                  70                  75                  80


Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys Gly Lys Thr 
                85                  90                  95


Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp Phe Thr Glu 
            100                 105                 110


Glu Glu Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys Glu Glu Lys 
        115                 120                 125


<210>  2878
<211>  1920
<212>  DNA
<213>  Homo sapiens

<400>  2878
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa gatttgggaa    480

tggatgatga aggagatgat gacccagttc ctctaccaaa tgtgaatgca gcaatattaa    540

aaaaggtcat tcagtggtgc acccaccaca aggatgaccc tcctcctcct gaagatgatg    600

agaacaaaga aaagcgaaca gatgatatcc ctgtttggga ccaagaattc ctgaaagttg    660

accaaggaac actttttgaa ctcattctgg ctgcaaacta cttagacatc aaaggtttgc    720

ttgatgttac atgcaagact gttgccaata tgatcaaggg gaaaactcct gaggagattc    780

gcaagacctt caatatcaaa aatgacttta ctgaagagga ggaagcccag cagggcagaa    840

taaaaaccat gggaggcaaa gaaaggaaat ccggaaatat agtcttaacc tggtgttgtt    900

ctaattttcc atctgttctt ctgactcaac tcactggcta tcgatgaatc agtaggtagt    960

atttataagt cttaggaaag actactcaag ttaaggtact tccctatatc catctctttt   1020

aggtacgcaa agagaaccag tggtgtgaag agaagtgaaa tgttgtgcct gacactgtaa   1080

cactgtaagg attgttccaa atactagttg cactgctctg tttataattg ttaatattag   1140

acaaacagta gacaaatgca gcagcaagtc aattgtatta gcagaatatt gtcctcattg   1200

catgtgtagt ttgagcacag atcccaaacc ttacggccaa gtttcttcta gtatgatgga   1260

aagtttcttt tttctttgct ctgaataaaa ctgaactgtg ggttctctat aagtggcatt   1320

ttgggctttc cctctttttt gtaaagcaat gtctgcctag tttattgtcc agttaacttt   1380

agtgaccttt taaaagttgg cattgtaaat aaaacaactt gcaaaaaagt tttctggaat   1440

agaattaaca aaatattatc tttattcatg agttggaaac tggaaaaagg cttcttgaag   1500

taaatgttct gagtggagct actaggatgt cttccagcct cctgcagtca aggagtacca   1560

ctgtattgat tagcctgtat gtagcagggc tcccttcatt gcatctgagg acttgttttc   1620

tttttcttta tttttaatcc tcttagtttt aaatatattg cctagagact cagttactac   1680

ccagtttgtg gttttttggg agaaatgtaa ctggacagtt agcttttcaa ttaaaaagac   1740

acttaaccca tgtgggatgt catcttttta taattagtgt tcccatgtgg agaaaattat   1800

tcacactact tgcatgtaaa gaataattta acttttaaca ttaaaatatg tggtaaaacc   1860

cagaaagcat ccatcatgaa tgcaagatac tttcaataaa aagtaagtta tatagtaggt   1920


<210>  2879
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  2879

Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95


Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp 
    130                 135                 140


Phe Thr Glu Glu Glu Glu Ala Gln Gln Gly Arg Ile Lys Thr Met Gly 
145                 150                 155                 160


Gly Lys Glu Arg Lys Ser Gly Asn Ile Val Leu Thr Trp Cys Cys Ser 
                165                 170                 175


Asn Phe Pro Ser Val Leu Leu Thr Gln Leu Thr Gly Tyr Arg 
            180                 185                 190


<210>  2880
<211>  1728
<212>  DNA
<213>  Homo sapiens

<400>  2880
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa gatttgggaa    480

tggatgatga aggagatgat gacccagttc ctctaccaaa tgtgaatgca gcaatattaa    540

aaaaggtcat tcagtggtgc acccaccaca aggatgaccc tcctcctcct gaagatgatg    600

agaacaaaga aaagcgaaca gatgatatcc ctgtttggga ccaagaattc ctgaaatata    660

ctttaaggaa aacaactgtc tctttacagg ctgcaaacta cttagacatc aaaggtttgc    720

ttgatgttac atgcaagact gttgccaata tgatcaaggg gaaaactcct gaggagattc    780

gcaagacctt caatatcaaa aatgacttta ctgaagagga ggaagcccag gtacgcaaag    840

agaaccagtg gtgtgaagag aagtgaaatg ttgtgcctga cactgtaaca ctgtaaggat    900

tgttccaaat actagttgca ctgctctgtt tataattgtt aatattagac aaacagtaga    960

caaatgcagc agcaagtcaa ttgtattagc agaatattgt cctcattgca tgtgtagttt   1020

gagcacagat cccaaacctt acggccaagt ttcttctagt atgatggaaa gtttcttttt   1080

tctttgctct gaataaaact gaactgtggg ttctctataa gtggcatttt gggctttccc   1140

tcttttttgt aaagcaatgt ctgcctagtt tattgtccag ttaactttag tgacctttta   1200

aaagttggca ttgtaaataa aacaacttgc aaaaaagttt tctggaatag aattaacaaa   1260

atattatctt tattcatgag ttggaaactg gaaaaaggct tcttgaagta aatgttctga   1320

gtggagctac taggatgtct tccagcctcc tgcagtcaag gagtaccact gtattgatta   1380

gcctgtatgt agcagggctc ccttcattgc atctgaggac ttgttttctt tttctttatt   1440

tttaatcctc ttagttttaa atatattgcc tagagactca gttactaccc agtttgtggt   1500

tttttgggag aaatgtaact ggacagttag cttttcaatt aaaaagacac ttaacccatg   1560

tgggatgtca tctttttata attagtgttc ccatgtggag aaaattattc acactacttg   1620

catgtaaaga ataatttaac ttttaacatt aaaatatgtg gtaaaaccca gaaagcatcc   1680

atcatgaatg caagatactt tcaataaaaa gtaagttata tagtaggt                1728


<210>  2881
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  2881

Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Tyr Thr 
                85                  90                  95


Leu Arg Lys Thr Thr Val Ser Leu Gln Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp 
    130                 135                 140


Phe Thr Glu Glu Glu Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys 
145                 150                 155                 160


Glu Glu Lys 



<210>  2882
<211>  2980
<212>  DNA
<213>  Homo sapiens

<400>  2882
aaaacaaaaa cctttcgctg gccaggcaca gtggctcata gctgtaatcc caacactttg     60

ggagggcaag gtgggtgaat tgcttgagtt caggagtttg caacatgatg aaaccttatc    120

tctacaaaaa caaaatacaa aaatgagcca ggtgtggtgg catgcacctg tagttgcagc    180

tacttgggag gctgaggtgg gaggatcgct taagcacagg aggtcgagtg agccatgatc    240

gcggcactgc attccagcct gggtgacaca gtgagatctt gtctcaaaaa caaacaaaca    300

accctttgct tggcttttcc ttattgaaat tgttctttct tttttttttt ttggatcctg    360

gcaatgtttc ttggctctgc cattttctct cagcattgtt tactcctcca acattttgct    420

atgaaaaagt tttagccata cagaaaaatg gaaagaatta cacagtagac aaccatgtag    480

ccactgccta gattctacaa ctgaaaacac tttcagtatt gattttggtc tttatgctgg    540

tatgtatagt ctaagtaatc agcttcctga aactttatgg agtaattatt ctcctattaa    600

ggaaattttg gggcttttcc tgctttgttc ctacaccaaa tagtctcaca catgtgtcta    660

gggtatttgg aatttgctgg ttacaatata tgtacatatt cagcttttct gaggagtgct    720

ggattagctt tcaaaggggt tataccaatt tatactctct agaagagttt gtgtttcctt    780

tccactattg cccaacaatt agtatcagtt tcttgatttt ttttcaatct agagaagtat    840

ctgtagtgtt agttttgctt ctagtaaagt tgagcgttcc ttatgtttgg ctattcagat    900

ttcatttatt ggctgtacat attaacccat ttctctttaa tgatttttga aagattttat    960

attctctcag ctaatcattg ttgtacatat tgcaggtatc ttccagtcat tgtcctaact   1020

tttctttttg catagaagct ttttaatgta gtcaagtaca gtactctgtc tgcatggctt   1080

gcttttatct aataagatct tctcccttct agggttataa tgattcttca agcttcattt   1140

ttgtttttca agcttggctg ttaatggctc aagtcaacct ctagctagtt attattccaa   1200

tatagggata agttgtccca gcagtggaat gagtaccttg tgacaaagtg ccacagagga   1260

atgaactttt gttgttgtag gtcattcagt ggtgcaccca ccacaaggat gaccctcctc   1320

ctcctgaaga tgatgagaac aaagaaaagc gaacagatga tatccctgtt tgggaccaag   1380

aattcctgaa agttgaccaa ggaacacttt ttgaactcat tctggctgca aactacttag   1440

acatcaaagg tttgcttgat gttacatgca agactgttgc caatatgatc aaggggaaaa   1500

ctcctgagga gattcgcaag accttcaata tcaaaaatga ctttactgaa gaggaggaag   1560

cccaggtagg tagcacacag ttttgtcttt gatcacatgc tcttaaaaag ggagtaacac   1620

ctataacatg ccagcaaaag aggtgactgt atcaagtagt cttgatactt tagggataat   1680

atgtacttaa tgtgtcttaa acatactctt actgttctgt ctttatgaat ctgaacactt   1740

agatgatact gcattttaag cataagaaca attagttttc aatgagaaga gctcttgtta   1800

atgtattaac agttactagt tttggcacct gcaactttct gtatagacca tacatatctg   1860

acatcagaaa agcaggccct agagagaagt atatactagg gtactttaga gcaacttaat   1920

gaggggagga aatgaaagaa tagatcagaa tgattttgtt gacatgacta cagactgaaa   1980

taatgtgaat gaattaactg aatttgctct gtcaacttta gtaaattgcc cattgccttt   2040

gctttgttca taatttcagc agggcagaat aaaaaccatg ggaggcaaag aaaggaaatc   2100

cggaaatata gtcttaacct ggtgttgttc taattttcca tctgttcttc tgactcaact   2160

cactggctat cgatgaatca gtaggtagta tttataagtc ttaggaaaga ctactcaagt   2220

taaggtactt ccctatatcc atctctttta ggtacgcaaa gagaaccagt ggtgtgaaga   2280

gaagtgaaat gttgtgcctg acactgtaac actgtaagga ttgttccaaa tactagttgc   2340

actgctctgt ttataattgt taatattaga caaacagtag acaaatgcag cagcaagtca   2400

attgtattag cagaatattg tcctcattgc atgtgtagtt tgagcacaga tcccaaacct   2460

tacggccaag tttcttctag tatgatggaa agtttctttt ttctttgctc tgaataaaac   2520

tgaactgtgg gttctctata agtggcattt tgggctttcc ctcttttttg taaagcaatg   2580

tctgcctagt ttattgtcca gttaacttta gtgacctttt aaaagttggc attgtaaata   2640

aaacaacttg caaaaaagtt ttctggaata gaattaacaa aatattatct ttattcatga   2700

gttggaaact ggaaaaaggc ttcttgaagt aaatgttctg agtggagcta ctaggatgtc   2760

ttccagcctc ctgcagtcaa ggagtaccac tgtattgatt agcctgtatg tagcagggct   2820

cccttcattg catctgagga cttgttttct ttttctttat ttttaatcct cttagtttta   2880

aatatattgc ctagagactc agttactacc cagtttgtgg ttttttggga gaaatgtaac   2940

tggacagtta gcttttcaat taaaaagaca cttaacccat                         2980


<210>  2883
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  2883

Met Tyr Ile Phe Ser Phe Ser Glu Glu Cys Trp Ile Ser Phe Gln Arg 
1               5                   10                  15


Gly Tyr Thr Asn Leu Tyr Ser Leu Glu Glu Phe Val Phe Pro Phe His 
            20                  25                  30


Tyr Cys Pro Thr Ile Ser Ile Ser Phe Leu Ile Phe Phe Gln Ser Arg 
        35                  40                  45


Glu Val Ser Val Val Leu Val Leu Leu Leu Val Lys Leu Ser Val Pro 
    50                  55                  60


Tyr Val Trp Leu Phe Arg Phe His Leu Leu Ala Val His Ile Asn Pro 
65                  70                  75                  80


Phe Leu Phe Asn Asp Phe 
                85


<210>  2884
<211>  1344
<212>  DNA
<213>  Homo sapiens

<400>  2884
gttgtcgacc ctgttcttcg ggagacccta ccaggttccg ttcacctgcc ccgcccccga     60

ctcagcgagg cctcctctgg ccgggcgtcc tcacggcgct ccataaacat aaatgagcat    120

attctgatgt actctttgga tctgaactca tcttcacaga tgccttcaat taagttgcag    180

agttctgatg gagagatatt tgaagttgat gtggaaattg ccaaacaatc tgtgactatt    240

aagaccatgt tggaagattt gggaatggat gatgaaggag atgatgaccc agttcctcta    300

ccaaatgtga atgcagcaat attaaaaaag gtcattcagt ggtgcaccca ccacaaggat    360

gaccctcctc ctcctgaaga tgatgagaac aaagaaaagc gaacagatga tatccctgtt    420

tgggaccaag aattcctgaa agttgaccaa ggaacacttt ttgaactcat tctggctgca    480

aactacttag acatcaaagg tttgcttgat gttacatgca agactgttgc caatatgatc    540

aaggggaaaa ctcctgagga gattcgcaag accttcaata tcaaaaatga ctttactgaa    600

gaggaggaag cccaggtacg caaagagaac cagtggtgtg aagagaagtg aaatgttgtg    660

cctgacactg taacactgta aggattgttc caaatactag ttgcactgct ctgtttataa    720

ttgttaatat tagacaaaca gtagacaaat gcagcagcaa gtcaattgta ttagcagaat    780

attgtcctca ttgcatgtgt agtttgagca cagatcccaa accttacggc caagtttctt    840

ctagtatgat ggaaagtttc ttttttcttt gctctgaata aaactgaact gtgggttctc    900

tataagtggc attttgggct ttccctcttt tttgtaaagc aatgtctgcc tagtttattg    960

tccagttaac tttagtgacc ttttaaaagt tggcattgta aataaaacaa cttgcaaaaa   1020

agttttctgg aatagaatta acaaaatatt atctttattc atgagttgga aactggaaaa   1080

aggcttcttg aagtaaatgt tctgagtgga gctactagga tgtcttccag cctcctgcag   1140

tcaaggagta ccactgtatt gattagcctg tatgtagcag ggctcccttc attgcatctg   1200

aggacttgtt ttctttttct ttatttttaa tcctcttagt tttaaatata ttgcctagag   1260

actcagttac tacccagttt gtggtttttt gggagaaatg taactggaca gttagctttt   1320

caattaaaaa gacacttaac ccat                                          1344


<210>  2885
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  2885

Met Tyr Ser Leu Asp Leu Asn Ser Ser Ser Gln Met Pro Ser Ile Lys 
1               5                   10                  15


Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val Asp Val Glu Ile Ala 
            20                  25                  30


Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu Asp Leu Gly Met Asp 
        35                  40                  45


Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro Asn Val Asn Ala Ala 
    50                  55                  60


Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His His Lys Asp Asp Pro 
65                  70                  75                  80


Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys Arg Thr Asp Asp Ile 
                85                  90                  95


Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp Gln Gly Thr Leu Phe 
            100                 105                 110


Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile Lys Gly Leu Leu Asp 
        115                 120                 125


Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys Gly Lys Thr Pro Glu 
    130                 135                 140


Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp Phe Thr Glu Glu Glu 
145                 150                 155                 160


Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys Glu Glu Lys 
                165                 170


<210>  2886
<211>  1647
<212>  DNA
<213>  Homo sapiens

<400>  2886
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa gtcactgttc    480

atcaagtacc tattgaatga agagtatgtt gtgctcacta aaaaaaactg aaagcaatcc    540

aagtgtccct aaaaggcaga tttgggaatg gatgatgaag gagatgatga cccagttcct    600

ctaccaaatg tgaatgcagc aatattaaaa aaggtcattc agtggtgcac ccaccacaag    660

gatgaccctc ctcctcctga agatgatgag aacaaagaaa agcgaacaga tgatatccct    720

gtttgggacc aagaattcct gaaagttgac caaggaacac tttttgaact cattctggct    780

gcaaactact tagacatcaa aggtttgctt gatgttacat gcaagactgt tgccaatatg    840

atcaagggga aaactcctga ggagattcgc aagaccttca atatcaaaaa tgactttact    900

gaagaggagg aagcccaggt acgcaaagag aaccagtggt gtgaagagaa gtgaaatgtt    960

gtgcctgaca ctgtaacact gtaaggattg ttccaaatac tagttgcact gctctgttta   1020

taattgttaa tattagacaa acagtagaca aatgcagcag caagtcaatt gtattagcag   1080

aatattgtcc tcattgcatg tgtagtttga gcacagatcc caaaccttac ggccaagttt   1140

cttctagtat gatggaaagt ttcttttttc tttgctctga ataaaactga actgtgggtt   1200

ctctataagt ggcattttgg gctttccctc ttttttgtaa agcaatgtct gcctagttta   1260

ttgtccagtt aactttagtg accttttaaa agttggcatt gtaaataaaa caacttgcaa   1320

aaaagttttc tggaatagaa ttaacaaaat attatcttta ttcatgagtt ggaaactgga   1380

aaaaggcttc ttgaagtaaa tgttctgagt ggagctacta ggatgtcttc cagcctcctg   1440

cagtcaagga gtaccactgt attgattagc ctgtatgtag cagggctccc ttcattgcat   1500

ctgaggactt gttttctttt tctttatttt taatcctctt agttttaaat atattgccta   1560

gagactcagt tactacccag tttgtggttt tttgggagaa atgtaactgg acagttagct   1620

tttcaattaa aaagacactt aacccat                                       1647


<210>  2887
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  2887

Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro Asn Val Asn 
1               5                   10                  15


Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His His Lys Asp 
            20                  25                  30


Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys Arg Thr Asp 
        35                  40                  45


Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp Gln Gly Thr 
    50                  55                  60


Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile Lys Gly Leu 
65                  70                  75                  80


Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys Gly Lys Thr 
                85                  90                  95


Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp Phe Thr Glu 
            100                 105                 110


Glu Glu Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys Glu Glu Lys 
        115                 120                 125


<210>  2888
<211>  1751
<212>  DNA
<213>  Homo sapiens

<400>  2888
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa gatttgggaa    480

tggatgatga aggagatgat gacccagttc ctctaccaaa tgtgaatgca gcaatattaa    540

aaaaggtcat tcagtggtgc acccaccaca aggatgaccc tcctcctcct gaagatgatg    600

agaacaaaga aaagcgaaca gatgatatcc ctgtttggga ccaagaattc ctgaaagttg    660

accaaggaac actttttgaa ctcattctgg ctgcaaacta cttagacatc aaaggtttgc    720

ttgatgttac atgcaagact gttgccaata tgatcaaggg gaaaactcct gaggagattc    780

gcaagacctt caatatcaaa aatgacttta ctgaagagga ggaagcccag cagggcagaa    840

taaaaaccat gggaggcaaa gaaaggaaat ccggaaatat agtcttaacc tggtgttgtt    900

ctaattttcc atctgttctt ctgactcaac tcactggcta tcgatgaatc agtaggtagt    960

atttataagt cttaggaaag actactcaag ttaaggtact tccctatatc catctctttt   1020

aggtacgcaa agagaaccag tggtgtgaag agaagtgaaa tgttgtgcct gacactgtaa   1080

cactgtaagg attgttccaa atactagttg cactgctctg tttataattg ttaatattag   1140

acaaacagta gacaaatgca gcagcaagtc aattgtatta gcagaatatt gtcctcattg   1200

catgtgtagt ttgagcacag atcccaaacc ttacggccaa gtttcttcta gtatgatgga   1260

aagtttcttt tttctttgct ctgaataaaa ctgaactgtg ggttctctat aagtggcatt   1320

ttgggctttc cctctttttt gtaaagcaat gtctgcctag tttattgtcc agttaacttt   1380

agtgaccttt taaaagttgg cattgtaaat aaaacaactt gcaaaaaagt tttctggaat   1440

agaattaaca aaatattatc tttattcatg agttggaaac tggaaaaagg cttcttgaag   1500

taaatgttct gagtggagct actaggatgt cttccagcct cctgcagtca aggagtacca   1560

ctgtattgat tagcctgtat gtagcagggc tcccttcatt gcatctgagg acttgttttc   1620

tttttcttta tttttaatcc tcttagtttt aaatatattg cctagagact cagttactac   1680

ccagtttgtg gttttttggg agaaatgtaa ctggacagtt agcttttcaa ttaaaaagac   1740

acttaaccca t                                                        1751


<210>  2889
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  2889

Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95


Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp 
    130                 135                 140


Phe Thr Glu Glu Glu Glu Ala Gln Gln Gly Arg Ile Lys Thr Met Gly 
145                 150                 155                 160


Gly Lys Glu Arg Lys Ser Gly Asn Ile Val Leu Thr Trp Cys Cys Ser 
                165                 170                 175


Asn Phe Pro Ser Val Leu Leu Thr Gln Leu Thr Gly Tyr Arg 
            180                 185                 190


<210>  2890
<211>  2245
<212>  DNA
<213>  Homo sapiens

<400>  2890
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa gatttgggaa    480

tggatgatga aggagatgat gacccagttc ctctaccaaa tgtgaatgca gcaatattaa    540

aaaaggtcat tcagtggtgc acccaccaca aggatgaccc tcctcctcct gaagatgatg    600

agaacaaaga aaagcgaaca gatgatatcc ctgtttggga ccaagaattc ctgaaagttg    660

accaaggaac actttttgaa ctcattctgg ctgcaaacta cttagacatc aaaggtttgc    720

ttgatgttac atgcaagact gttgccaata tgatcaaggg gaaaactcct gaggagattc    780

gcaagacctt caatatcaaa aatgacttta ctgaagagga ggaagcccag gtaggtagca    840

cacagttttg tctttgatca catgctctta aaaagggagt aacacctata acatgccagc    900

aaaagaggtg actgtatcaa gtagtcttga tactttaggg ataatatgta cttaatgtgt    960

cttaaacata ctcttactgt tctgtcttta tgaatctgaa cacttagatg atactgcatt   1020

ttaagcataa gaacaattag ttttcaatga gaagagctct tgttaatgta ttaacagtta   1080

ctagttttgg cacctgcaac tttctgtata gaccatacat atctgacatc agaaaagcag   1140

gccctagaga gaagtatata ctagggtact ttagagcaac ttaatgaggg gaggaaatga   1200

aagaatagat cagaatgatt ttgttgacat gactacagac tgaaataatg tgaatgaatt   1260

aactgaattt gctctgtcaa ctttagtaaa ttgcccattg cctttgcttt gttcataatt   1320

tcagcagggc agaataaaaa ccatgggagg caaagaaagg aaatccggaa atatagtctt   1380

aacctggtgt tgttctaatt ttccatctgt tcttctgact caactcactg gctatcgatg   1440

aatcagtagg tagtatttat aagtcttagg aaagactact caagttaagg tacttcccta   1500

tatccatctc ttttaggtac gcaaagagaa ccagtggtgt gaagagaagt gaaatgttgt   1560

gcctgacact gtaacactgt aaggattgtt ccaaatacta gttgcactgc tctgtttata   1620

attgttaata ttagacaaac agtagacaaa tgcagcagca agtcaattgt attagcagaa   1680

tattgtcctc attgcatgtg tagtttgagc acagatccca aaccttacgg ccaagtttct   1740

tctagtatga tggaaagttt cttttttctt tgctctgaat aaaactgaac tgtgggttct   1800

ctataagtgg cattttgggc tttccctctt ttttgtaaag caatgtctgc ctagtttatt   1860

gtccagttaa ctttagtgac cttttaaaag ttggcattgt aaataaaaca acttgcaaaa   1920

aagttttctg gaatagaatt aacaaaatat tatctttatt catgagttgg aaactggaaa   1980

aaggcttctt gaagtaaatg ttctgagtgg agctactagg atgtcttcca gcctcctgca   2040

gtcaaggagt accactgtat tgattagcct gtatgtagca gggctccctt cattgcatct   2100

gaggacttgt tttctttttc tttattttta atcctcttag ttttaaatat attgcctaga   2160

gactcagtta ctacccagtt tgtggttttt tgggagaaat gtaactggac agttagcttt   2220

tcaattaaaa agacacttaa cccat                                         2245


<210>  2891
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  2891

Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95


Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp 
    130                 135                 140


Phe Thr Glu Glu Glu Glu Ala Gln Val Gly Ser Thr Gln Phe Cys Leu 
145                 150                 155                 160


<210>  2892
<211>  1559
<212>  DNA
<213>  Homo sapiens

<400>  2892
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa gatttgggaa    480

tggatgatga aggagatgat gacccagttc ctctaccaaa tgtgaatgca gcaatattaa    540

aaaaggtcat tcagtggtgc acccaccaca aggatgaccc tcctcctcct gaagatgatg    600

agaacaaaga aaagcgaaca gatgatatcc ctgtttggga ccaagaattc ctgaaagttg    660

accaaggaac actttttgaa ctcattctgg ctgcaaacta cttagacatc aaaggtttgc    720

ttgatgttac atgcaagact gttgccaata tgatcaaggg gaaaactcct gaggagattc    780

gcaagacctt caatatcaaa aatgacttta ctgaagagga ggaagcccag gtacgcaaag    840

agaaccagtg gtgtgaagag aagtgaaatg ttgtgcctga cactgtaaca ctgtaaggat    900

tgttccaaat actagttgca ctgctctgtt tataattgtt aatattagac aaacagtaga    960

caaatgcagc agcaagtcaa ttgtattagc agaatattgt cctcattgca tgtgtagttt   1020

gagcacagat cccaaacctt acggccaagt ttcttctagt atgatggaaa gtttcttttt   1080

tctttgctct gaataaaact gaactgtggg ttctctataa gtggcatttt gggctttccc   1140

tcttttttgt aaagcaatgt ctgcctagtt tattgtccag ttaactttag tgacctttta   1200

aaagttggca ttgtaaataa aacaacttgc aaaaaagttt tctggaatag aattaacaaa   1260

atattatctt tattcatgag ttggaaactg gaaaaaggct tcttgaagta aatgttctga   1320

gtggagctac taggatgtct tccagcctcc tgcagtcaag gagtaccact gtattgatta   1380

gcctgtatgt agcagggctc ccttcattgc atctgaggac ttgttttctt tttctttatt   1440

tttaatcctc ttagttttaa atatattgcc tagagactca gttactaccc agtttgtggt   1500

tttttgggag aaatgtaact ggacagttag cttttcaatt aaaaagacac ttaacccat    1559


<210>  2893
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  2893

Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95


Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp 
    130                 135                 140


Phe Thr Glu Glu Glu Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys 
145                 150                 155                 160


Glu Glu Lys 



<210>  2894
<211>  1612
<212>  DNA
<213>  Homo sapiens

<400>  2894
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccacataa atgagcatat tctgatgtac tctttggatc tgaactcatc    420

ttcacagatg ccttcaatta agttgcagag ttctgatgga gagatatttg aagttgatgt    480

ggaaattgcc aaacaatctg tgactattaa gaccatgttg gaagatttgg gaatggatga    540

tgaaggagat gatgacccag ttcctctacc aaatgtgaat gcagcaatat taaaaaaggt    600

cattcagtgg tgcacccacc acaaggatga ccctcctcct cctgaagatg atgagaacaa    660

agaaaagcga acagatgata tccctgtttg ggaccaagaa ttcctgaaag ttgaccaagg    720

aacacttttt gaactcattc tggctgcaaa ctacttagac atcaaaggtt tgcttgatgt    780

tacatgcaag actgttgcca atatgatcaa ggggaaaact cctgaggaga ttcgcaagac    840

cttcaatatc aaaaatgact ttactgaaga ggaggaagcc caggtacgca aagagaacca    900

gtggtgtgaa gagaagtgaa atgttgtgcc tgacactgta acactgtaag gattgttcca    960

aatactagtt gcactgctct gtttataatt gttaatatta gacaaacagt agacaaatgc   1020

agcagcaagt caattgtatt agcagaatat tgtcctcatt gcatgtgtag tttgagcaca   1080

gatcccaaac cttacggcca agtttcttct agtatgatgg aaagtttctt ttttctttgc   1140

tctgaataaa actgaactgt gggttctcta taagtggcat tttgggcttt ccctcttttt   1200

tgtaaagcaa tgtctgccta gtttattgtc cagttaactt tagtgacctt ttaaaagttg   1260

gcattgtaaa taaaacaact tgcaaaaaag ttttctggaa tagaattaac aaaatattat   1320

ctttattcat gagttggaaa ctggaaaaag gcttcttgaa gtaaatgttc tgagtggagc   1380

tactaggatg tcttccagcc tcctgcagtc aaggagtacc actgtattga ttagcctgta   1440

tgtagcaggg ctcccttcat tgcatctgag gacttgtttt ctttttcttt atttttaatc   1500

ctcttagttt taaatatatt gcctagagac tcagttacta cccagtttgt ggttttttgg   1560

gagaaatgta actggacagt tagcttttca attaaaaaga cacttaaccc at           1612


<210>  2895
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  2895

Met Tyr Ser Leu Asp Leu Asn Ser Ser Ser Gln Met Pro Ser Ile Lys 
1               5                   10                  15


Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val Asp Val Glu Ile Ala 
            20                  25                  30


Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu Asp Leu Gly Met Asp 
        35                  40                  45


Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro Asn Val Asn Ala Ala 
    50                  55                  60


Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His His Lys Asp Asp Pro 
65                  70                  75                  80


Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys Arg Thr Asp Asp Ile 
                85                  90                  95


Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp Gln Gly Thr Leu Phe 
            100                 105                 110


Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile Lys Gly Leu Leu Asp 
        115                 120                 125


Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys Gly Lys Thr Pro Glu 
    130                 135                 140


Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp Phe Thr Glu Glu Glu 
145                 150                 155                 160


Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys Glu Glu Lys 
                165                 170


<210>  2896
<211>  1559
<212>  DNA
<213>  Homo sapiens

<400>  2896
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa gatttgggaa    480

tggatgatga aggagatgat gacccagttc ctctaccaaa tgtgaatgca gcaatattaa    540

aaaaggtcat tcagtggtgc acccaccaca aggatgaccc tcctcctcct gaagatgatg    600

agaacaaaga aaagcgaaca gatgatatcc ctgtttggga ccaagaattc ctgaaatata    660

ctttaaggaa aacaactgtc tctttacagg ctgcaaacta cttagacatc aaaggtttgc    720

ttgatgttac atgcaagact gttgccaata tgatcaaggg gaaaactcct gaggagattc    780

gcaagacctt caatatcaaa aatgacttta ctgaagagga ggaagcccag gtacgcaaag    840

agaaccagtg gtgtgaagag aagtgaaatg ttgtgcctga cactgtaaca ctgtaaggat    900

tgttccaaat actagttgca ctgctctgtt tataattgtt aatattagac aaacagtaga    960

caaatgcagc agcaagtcaa ttgtattagc agaatattgt cctcattgca tgtgtagttt   1020

gagcacagat cccaaacctt acggccaagt ttcttctagt atgatggaaa gtttcttttt   1080

tctttgctct gaataaaact gaactgtggg ttctctataa gtggcatttt gggctttccc   1140

tcttttttgt aaagcaatgt ctgcctagtt tattgtccag ttaactttag tgacctttta   1200

aaagttggca ttgtaaataa aacaacttgc aaaaaagttt tctggaatag aattaacaaa   1260

atattatctt tattcatgag ttggaaactg gaaaaaggct tcttgaagta aatgttctga   1320

gtggagctac taggatgtct tccagcctcc tgcagtcaag gagtaccact gtattgatta   1380

gcctgtatgt agcagggctc ccttcattgc atctgaggac ttgttttctt tttctttatt   1440

tttaatcctc ttagttttaa atatattgcc tagagactca gttactaccc agtttgtggt   1500

tttttgggag aaatgtaact ggacagttag cttttcaatt aaaaagacac ttaacccat    1559


<210>  2897
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  2897

Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Tyr Thr 
                85                  90                  95


Leu Arg Lys Thr Thr Val Ser Leu Gln Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp 
    130                 135                 140


Phe Thr Glu Glu Glu Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys 
145                 150                 155                 160


Glu Glu Lys 



<210>  2898
<211>  722
<212>  DNA
<213>  Homo sapiens

<400>  2898
ggctgcaaac tacttagaca tcaaaggttt gcttgatgtt acatgcaaga ctgttgccaa     60

tatgatcaag gggaaaactc ctgaggagat tcgcaagacc ttcaatatca aaaatgactt    120

tactgaagag gaggaagccc aggtacgcaa agagaaccag tggtgtgaag agaagtgaaa    180

ttttgagcac agatcccaaa ccttacggcc aagtttcttc tagtatgatg gaaagtttct    240

tttttctttg ctctgaataa aactgaactg tgggttctct ataagtggca ttttgggctt    300

tccctctttt ttgtaaagca atgtctgcct agtttattgt ccagttaact ttagtgacct    360

tttaaaagtt ggcattgtaa ataaaacaac ttgcaaaaaa gttttctgga atagaattaa    420

caaaatatta tctttattca tgagttggaa actggaaaaa ggcttcttga agtaaatgtt    480

ctgagtggag ctactaggat gtcttccagc ctcctgcagt caaggagtac cactgtattg    540

attagcctgt atgtagcagg gctcccttca ttgcatctga ggacttgttt tctttttctt    600

tatttttaat cctcttagtt ttaaatatat tgcctagaga ctcagttact acccagtttg    660

tggttttttg ggagaaatgt aactggacag ttagcttttc aattaaaaag acacttaacc    720

ca                                                                   722


<210>  2899
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  2899

Met Thr Leu Leu Lys Arg Arg Lys Pro Arg Tyr Ala Lys Arg Thr Ser 
1               5                   10                  15


Gly Val Lys Arg Ser Glu Ile Leu Ser Thr Asp Pro Lys Pro Tyr Gly 
            20                  25                  30


Gln Val Ser Ser Ser Met Met Glu Ser Phe Phe Phe Leu Cys Ser Glu 
        35                  40                  45


<210>  2900
<211>  1231
<212>  DNA
<213>  Homo sapiens

<400>  2900
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa gatttgggaa    480

tggatgatga aggagatgat gacccagttc ctctaccaaa tgtgaatgca gcaatattaa    540

aaaaggtcat tcagtggtgc acccaccaca aggatgaccc tcctcctcct gaagatgatg    600

agaacaaaga aaagcgaaca gatgatatcc ctgtttggga ccaagaattc ctgaaagttg    660

accaaggaac actttttgaa ctcattctgg ctgcaaacta cttagacatc aaaggtttgc    720

ttgatgttac atgcaagact gttgccaata tgatcaaggg gaaaactcct gaggagattc    780

gcaagacctt caatatcaaa aatgagcttt ccctcttttt tgtaaagcaa tgtctgccta    840

gtttattgtc cagttaactt tagtgacctt ttaaaagttg gcattgtaaa taaaacaact    900

tgcaaaaaag ttttctggaa tagaattaac aaaatattat ctttattcat gagttggaaa    960

ctggaaaaag gcttcttgaa gtaaatgttc tgagtggagc tactaggatg tcttccagcc   1020

tcctgcagtc aaggagtacc actgtattga ttagcctgta tgtagcaggg ctcccttcat   1080

tgcatctgag gacttgtttt ctttttcttt atttttaatc ctcttagttt taaatatatt   1140

gcctagagac tcagttacta cccagtttgt ggttttttgg gagaaatgta actggacagt   1200

tagcttttca attaaaaaga cacttaaccc a                                  1231


<210>  2901
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  2901

Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95


Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Glu 
    130                 135                 140


Leu Ser Leu Phe Phe Val Lys Gln Cys Leu Pro Ser Leu Leu Ser Ser 
145                 150                 155                 160


<210>  2902
<211>  2678
<212>  DNA
<213>  Homo sapiens

<400>  2902
aaaacaaaaa cctttcgctg gccaggcaca gtggctcata gctgtaatcc caacactttg     60

ggagggcaag gtgggtgaat tgcttgagtt caggagtttg caacatgatg aaaccttatc    120

tctacaaaaa caaaatacaa aaatgagcca ggtgtggtgg catgcacctg tagttgcagc    180

tacttgggag gctgaggtgg gaggatcgct taagcacagg aggtcgagtg agccatgatc    240

gcggcactgc attccagcct gggtgacaca gtgagatctt gtctcaaaaa caaacaaaca    300

accctttgct tggcttttcc ttattgaaat tgttctttct tttttttttt ttggatcctg    360

gcaatgtttc ttggctctgc cattttctct cagcattgtt tactcctcca acattttgct    420

atgaaaaagt tttagccata cagaaaaatg gaaagaatta cacagtagac aaccatgtag    480

ccactgccta gattctacaa ctgaaaacac tttcagtatt gattttggtc tttatgctgg    540

tatgtatagt ctaagtaatc agcttcctga aactttatgg agtaattatt ctcctattaa    600

ggaaattttg gggcttttcc tgctttgttc ctacaccaaa tagtctcaca catgtgtcta    660

gggtatttgg aatttgctgg ttacaatata tgtacatatt cagcttttct gaggagtgct    720

ggattagctt tcaaaggggt tataccaatt tatactctct agaagagttt gtgtttcctt    780

tccactattg cccaacaatt agtatcagtt tcttgatttt ttttcaatct agagaagtat    840

ctgtagtgtt agttttgctt ctagtaaagt tgagcgttcc ttatgtttgg ctattcagat    900

ttcatttatt ggctgtacat attaacccat ttctctttaa tgatttttga aagattttat    960

attctctcag ctaatcattg ttgtacatat tgcaggtatc ttccagtcat tgtcctaact   1020

tttctttttg catagaagct ttttaatgta gtcaagtaca gtactctgtc tgcatggctt   1080

gcttttatct aataagatct tctcccttct agggttataa tgattcttca agcttcattt   1140

ttgtttttca agcttggctg ttaatggctc aagtcaacct ctagctagtt attattccaa   1200

tatagggata agttgtccca gcagtggaat gagtaccttg tgacaaagtg ccacagagga   1260

atgaactttt gttgttgtag gtcattcagt ggtgcaccca ccacaaggat gaccctcctc   1320

ctcctgaaga tgatgagaac aaagaaaagc gaacagatga tatccctgtt tgggaccaag   1380

aattcctgaa agttgaccaa ggaacacttt ttgaactcat tctggctgca aactacttag   1440

acatcaaagg tttgcttgat gttacatgca agactgttgc caatatgatc aaggggaaaa   1500

ctcctgagga gattcgcaag accttcaata tcaaaaatga ctttactgaa gaggaggaag   1560

cccaggtagg tagcacacag ttttgtcttt gatcacatgc tcttaaaaag ggagtaacac   1620

ctataacatg ccagcaaaag aggtgactgt atcaagtagt cttgatactt tagggataat   1680

atgtacttaa tgtgtcttaa acatactctt actgttctgt ctttatgaat ctgaacactt   1740

agatgatact gcattttaag cataagaaca attagttttc aatgagaaga gctcttgtta   1800

atgtattaac agttactagt tttggcacct gcaactttct gtatagacca tacatatctg   1860

acatcagaaa agcaggccct agagagaagt atatactagg gtactttaga gcaacttaat   1920

gaggggagga aatgaaagaa tagatcagaa tgattttgtt gacatgacta cagactgaaa   1980

taatgtgaat gaattaactg aatttgctct gtcaacttta gtaaattgcc cattgccttt   2040

gctttgttca taatttcagc agggcagaat aaaaaccatg ggaggcaaag aaaggaaatc   2100

cggaaatata gtcttaacct ggtgttgttc taattttcca tctgttcttc tgactcaact   2160

cactggctat cgatgaatca gtaggtagta tttataagtc ttaggaaaga ctactcaagt   2220

taaggtactt ccctatatcc atctctttta ggtacgcaaa gagaaccagt ggtgtgaaga   2280

gaagtgaaat gttgtgcctg acactgtaac actgtaagga ttgttccaaa tactagttgc   2340

actgctctgt ttataattgt taatattaga caaacagtag acaaatgcag cagcaagtca   2400

attgtattag cagaatattg tcctcattgc atgtgtagtt tgagcacaga tcccaaacct   2460

tacggccaag tttcttctag tatgatggaa agtttctttt ttctttgctc tgaataaaac   2520

tgaactgtgg gttctctata agtggcattt tgggctttcc ctcttttttg taaagcaatg   2580

tctgcctagt ttattgtcca gttaacttta gtgacctttt aaaagttggc attgtaaata   2640

aaacaacttg caaaaaagtt ttctggaata gaattaac                           2678


<210>  2903
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  2903

Met Tyr Ile Phe Ser Phe Ser Glu Glu Cys Trp Ile Ser Phe Gln Arg 
1               5                   10                  15


Gly Tyr Thr Asn Leu Tyr Ser Leu Glu Glu Phe Val Phe Pro Phe His 
            20                  25                  30


Tyr Cys Pro Thr Ile Ser Ile Ser Phe Leu Ile Phe Phe Gln Ser Arg 
        35                  40                  45


Glu Val Ser Val Val Leu Val Leu Leu Leu Val Lys Leu Ser Val Pro 
    50                  55                  60


Tyr Val Trp Leu Phe Arg Phe His Leu Leu Ala Val His Ile Asn Pro 
65                  70                  75                  80


Phe Leu Phe Asn Asp Phe 
                85


<210>  2904
<211>  1042
<212>  DNA
<213>  Homo sapiens

<400>  2904
gttgtcgacc ctgttcttcg ggagacccta ccaggttccg ttcacctgcc ccgcccccga     60

ctcagcgagg cctcctctgg ccgggcgtcc tcacggcgct ccataaacat aaatgagcat    120

attctgatgt actctttgga tctgaactca tcttcacaga tgccttcaat taagttgcag    180

agttctgatg gagagatatt tgaagttgat gtggaaattg ccaaacaatc tgtgactatt    240

aagaccatgt tggaagattt gggaatggat gatgaaggag atgatgaccc agttcctcta    300

ccaaatgtga atgcagcaat attaaaaaag gtcattcagt ggtgcaccca ccacaaggat    360

gaccctcctc ctcctgaaga tgatgagaac aaagaaaagc gaacagatga tatccctgtt    420

tgggaccaag aattcctgaa agttgaccaa ggaacacttt ttgaactcat tctggctgca    480

aactacttag acatcaaagg tttgcttgat gttacatgca agactgttgc caatatgatc    540

aaggggaaaa ctcctgagga gattcgcaag accttcaata tcaaaaatga ctttactgaa    600

gaggaggaag cccaggtacg caaagagaac cagtggtgtg aagagaagtg aaatgttgtg    660

cctgacactg taacactgta aggattgttc caaatactag ttgcactgct ctgtttataa    720

ttgttaatat tagacaaaca gtagacaaat gcagcagcaa gtcaattgta ttagcagaat    780

attgtcctca ttgcatgtgt agtttgagca cagatcccaa accttacggc caagtttctt    840

ctagtatgat ggaaagtttc ttttttcttt gctctgaata aaactgaact gtgggttctc    900

tataagtggc attttgggct ttccctcttt tttgtaaagc aatgtctgcc tagtttattg    960

tccagttaac tttagtgacc ttttaaaagt tggcattgta aataaaacaa cttgcaaaaa   1020

agttttctgg aatagaatta ac                                            1042


<210>  2905
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  2905

Met Tyr Ser Leu Asp Leu Asn Ser Ser Ser Gln Met Pro Ser Ile Lys 
1               5                   10                  15


Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val Asp Val Glu Ile Ala 
            20                  25                  30


Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu Asp Leu Gly Met Asp 
        35                  40                  45


Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro Asn Val Asn Ala Ala 
    50                  55                  60


Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His His Lys Asp Asp Pro 
65                  70                  75                  80


Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys Arg Thr Asp Asp Ile 
                85                  90                  95


Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp Gln Gly Thr Leu Phe 
            100                 105                 110


Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile Lys Gly Leu Leu Asp 
        115                 120                 125


Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys Gly Lys Thr Pro Glu 
    130                 135                 140


Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp Phe Thr Glu Glu Glu 
145                 150                 155                 160


Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys Glu Glu Lys 
                165                 170


<210>  2906
<211>  1449
<212>  DNA
<213>  Homo sapiens

<400>  2906
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa gatttgggaa    480

tggatgatga aggagatgat gacccagttc ctctaccaaa tgtgaatgca gcaatattaa    540

aaaaggtcat tcagtggtgc acccaccaca aggatgaccc tcctcctcct gaagatgatg    600

agaacaaaga aaagcgaaca gatgatatcc ctgtttggga ccaagaattc ctgaaagttg    660

accaaggaac actttttgaa ctcattctgg ctgcaaacta cttagacatc aaaggtttgc    720

ttgatgttac atgcaagact gttgccaata tgatcaaggg gaaaactcct gaggagattc    780

gcaagacctt caatatcaaa aatgacttta ctgaagagga ggaagcccag cagggcagaa    840

taaaaaccat gggaggcaaa gaaaggaaat ccggaaatat agtcttaacc tggtgttgtt    900

ctaattttcc atctgttctt ctgactcaac tcactggcta tcgatgaatc agtaggtagt    960

atttataagt cttaggaaag actactcaag ttaaggtact tccctatatc catctctttt   1020

aggtacgcaa agagaaccag tggtgtgaag agaagtgaaa tgttgtgcct gacactgtaa   1080

cactgtaagg attgttccaa atactagttg cactgctctg tttataattg ttaatattag   1140

acaaacagta gacaaatgca gcagcaagtc aattgtatta gcagaatatt gtcctcattg   1200

catgtgtagt ttgagcacag atcccaaacc ttacggccaa gtttcttcta gtatgatgga   1260

aagtttcttt tttctttgct ctgaataaaa ctgaactgtg ggttctctat aagtggcatt   1320

ttgggctttc cctctttttt gtaaagcaat gtctgcctag tttattgtcc agttaacttt   1380

agtgaccttt taaaagttgg cattgtaaat aaaacaactt gcaaaaaagt tttctggaat   1440

agaattaac                                                           1449


<210>  2907
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  2907

Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95


Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp 
    130                 135                 140


Phe Thr Glu Glu Glu Glu Ala Gln Gln Gly Arg Ile Lys Thr Met Gly 
145                 150                 155                 160


Gly Lys Glu Arg Lys Ser Gly Asn Ile Val Leu Thr Trp Cys Cys Ser 
                165                 170                 175


Asn Phe Pro Ser Val Leu Leu Thr Gln Leu Thr Gly Tyr Arg 
            180                 185                 190


<210>  2908
<211>  1345
<212>  DNA
<213>  Homo sapiens

<400>  2908
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa gtcactgttc    480

atcaagtacc tattgaatga agagtatgtt gtgctcacta aaaaaaactg aaagcaatcc    540

aagtgtccct aaaaggcaga tttgggaatg gatgatgaag gagatgatga cccagttcct    600

ctaccaaatg tgaatgcagc aatattaaaa aaggtcattc agtggtgcac ccaccacaag    660

gatgaccctc ctcctcctga agatgatgag aacaaagaaa agcgaacaga tgatatccct    720

gtttgggacc aagaattcct gaaagttgac caaggaacac tttttgaact cattctggct    780

gcaaactact tagacatcaa aggtttgctt gatgttacat gcaagactgt tgccaatatg    840

atcaagggga aaactcctga ggagattcgc aagaccttca atatcaaaaa tgactttact    900

gaagaggagg aagcccaggt acgcaaagag aaccagtggt gtgaagagaa gtgaaatgtt    960

gtgcctgaca ctgtaacact gtaaggattg ttccaaatac tagttgcact gctctgttta   1020

taattgttaa tattagacaa acagtagaca aatgcagcag caagtcaatt gtattagcag   1080

aatattgtcc tcattgcatg tgtagtttga gcacagatcc caaaccttac ggccaagttt   1140

cttctagtat gatggaaagt ttcttttttc tttgctctga ataaaactga actgtgggtt   1200

ctctataagt ggcattttgg gctttccctc ttttttgtaa agcaatgtct gcctagttta   1260

ttgtccagtt aactttagtg accttttaaa agttggcatt gtaaataaaa caacttgcaa   1320

aaaagttttc tggaatagaa ttaac                                         1345


<210>  2909
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  2909

Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro Asn Val Asn 
1               5                   10                  15


Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His His Lys Asp 
            20                  25                  30


Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys Arg Thr Asp 
        35                  40                  45


Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp Gln Gly Thr 
    50                  55                  60


Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile Lys Gly Leu 
65                  70                  75                  80


Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys Gly Lys Thr 
                85                  90                  95


Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp Phe Thr Glu 
            100                 105                 110


Glu Glu Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys Glu Glu Lys 
        115                 120                 125


<210>  2910
<211>  1943
<212>  DNA
<213>  Homo sapiens

<400>  2910
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa gatttgggaa    480

tggatgatga aggagatgat gacccagttc ctctaccaaa tgtgaatgca gcaatattaa    540

aaaaggtcat tcagtggtgc acccaccaca aggatgaccc tcctcctcct gaagatgatg    600

agaacaaaga aaagcgaaca gatgatatcc ctgtttggga ccaagaattc ctgaaagttg    660

accaaggaac actttttgaa ctcattctgg ctgcaaacta cttagacatc aaaggtttgc    720

ttgatgttac atgcaagact gttgccaata tgatcaaggg gaaaactcct gaggagattc    780

gcaagacctt caatatcaaa aatgacttta ctgaagagga ggaagcccag gtaggtagca    840

cacagttttg tctttgatca catgctctta aaaagggagt aacacctata acatgccagc    900

aaaagaggtg actgtatcaa gtagtcttga tactttaggg ataatatgta cttaatgtgt    960

cttaaacata ctcttactgt tctgtcttta tgaatctgaa cacttagatg atactgcatt   1020

ttaagcataa gaacaattag ttttcaatga gaagagctct tgttaatgta ttaacagtta   1080

ctagttttgg cacctgcaac tttctgtata gaccatacat atctgacatc agaaaagcag   1140

gccctagaga gaagtatata ctagggtact ttagagcaac ttaatgaggg gaggaaatga   1200

aagaatagat cagaatgatt ttgttgacat gactacagac tgaaataatg tgaatgaatt   1260

aactgaattt gctctgtcaa ctttagtaaa ttgcccattg cctttgcttt gttcataatt   1320

tcagcagggc agaataaaaa ccatgggagg caaagaaagg aaatccggaa atatagtctt   1380

aacctggtgt tgttctaatt ttccatctgt tcttctgact caactcactg gctatcgatg   1440

aatcagtagg tagtatttat aagtcttagg aaagactact caagttaagg tacttcccta   1500

tatccatctc ttttaggtac gcaaagagaa ccagtggtgt gaagagaagt gaaatgttgt   1560

gcctgacact gtaacactgt aaggattgtt ccaaatacta gttgcactgc tctgtttata   1620

attgttaata ttagacaaac agtagacaaa tgcagcagca agtcaattgt attagcagaa   1680

tattgtcctc attgcatgtg tagtttgagc acagatccca aaccttacgg ccaagtttct   1740

tctagtatga tggaaagttt cttttttctt tgctctgaat aaaactgaac tgtgggttct   1800

ctataagtgg cattttgggc tttccctctt ttttgtaaag caatgtctgc ctagtttatt   1860

gtccagttaa ctttagtgac cttttaaaag ttggcattgt aaataaaaca acttgcaaaa   1920

aagttttctg gaatagaatt aac                                           1943


<210>  2911
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  2911

Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95


Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp 
    130                 135                 140


Phe Thr Glu Glu Glu Glu Ala Gln Val Gly Ser Thr Gln Phe Cys Leu 
145                 150                 155                 160


<210>  2912
<211>  1257
<212>  DNA
<213>  Homo sapiens

<400>  2912
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa gatttgggaa    480

tggatgatga aggagatgat gacccagttc ctctaccaaa tgtgaatgca gcaatattaa    540

aaaaggtcat tcagtggtgc acccaccaca aggatgaccc tcctcctcct gaagatgatg    600

agaacaaaga aaagcgaaca gatgatatcc ctgtttggga ccaagaattc ctgaaagttg    660

accaaggaac actttttgaa ctcattctgg ctgcaaacta cttagacatc aaaggtttgc    720

ttgatgttac atgcaagact gttgccaata tgatcaaggg gaaaactcct gaggagattc    780

gcaagacctt caatatcaaa aatgacttta ctgaagagga ggaagcccag gtacgcaaag    840

agaaccagtg gtgtgaagag aagtgaaatg ttgtgcctga cactgtaaca ctgtaaggat    900

tgttccaaat actagttgca ctgctctgtt tataattgtt aatattagac aaacagtaga    960

caaatgcagc agcaagtcaa ttgtattagc agaatattgt cctcattgca tgtgtagttt   1020

gagcacagat cccaaacctt acggccaagt ttcttctagt atgatggaaa gtttcttttt   1080

tctttgctct gaataaaact gaactgtggg ttctctataa gtggcatttt gggctttccc   1140

tcttttttgt aaagcaatgt ctgcctagtt tattgtccag ttaactttag tgacctttta   1200

aaagttggca ttgtaaataa aacaacttgc aaaaaagttt tctggaatag aattaac      1257


<210>  2913
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  2913

Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95


Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp 
    130                 135                 140


Phe Thr Glu Glu Glu Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys 
145                 150                 155                 160


Glu Glu Lys 



<210>  2914
<211>  1310
<212>  DNA
<213>  Homo sapiens

<400>  2914
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccacataa atgagcatat tctgatgtac tctttggatc tgaactcatc    420

ttcacagatg ccttcaatta agttgcagag ttctgatgga gagatatttg aagttgatgt    480

ggaaattgcc aaacaatctg tgactattaa gaccatgttg gaagatttgg gaatggatga    540

tgaaggagat gatgacccag ttcctctacc aaatgtgaat gcagcaatat taaaaaaggt    600

cattcagtgg tgcacccacc acaaggatga ccctcctcct cctgaagatg atgagaacaa    660

agaaaagcga acagatgata tccctgtttg ggaccaagaa ttcctgaaag ttgaccaagg    720

aacacttttt gaactcattc tggctgcaaa ctacttagac atcaaaggtt tgcttgatgt    780

tacatgcaag actgttgcca atatgatcaa ggggaaaact cctgaggaga ttcgcaagac    840

cttcaatatc aaaaatgact ttactgaaga ggaggaagcc caggtacgca aagagaacca    900

gtggtgtgaa gagaagtgaa atgttgtgcc tgacactgta acactgtaag gattgttcca    960

aatactagtt gcactgctct gtttataatt gttaatatta gacaaacagt agacaaatgc   1020

agcagcaagt caattgtatt agcagaatat tgtcctcatt gcatgtgtag tttgagcaca   1080

gatcccaaac cttacggcca agtttcttct agtatgatgg aaagtttctt ttttctttgc   1140

tctgaataaa actgaactgt gggttctcta taagtggcat tttgggcttt ccctcttttt   1200

tgtaaagcaa tgtctgccta gtttattgtc cagttaactt tagtgacctt ttaaaagttg   1260

gcattgtaaa taaaacaact tgcaaaaaag ttttctggaa tagaattaac              1310


<210>  2915
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  2915

Met Tyr Ser Leu Asp Leu Asn Ser Ser Ser Gln Met Pro Ser Ile Lys 
1               5                   10                  15


Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val Asp Val Glu Ile Ala 
            20                  25                  30


Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu Asp Leu Gly Met Asp 
        35                  40                  45


Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro Asn Val Asn Ala Ala 
    50                  55                  60


Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His His Lys Asp Asp Pro 
65                  70                  75                  80


Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys Arg Thr Asp Asp Ile 
                85                  90                  95


Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp Gln Gly Thr Leu Phe 
            100                 105                 110


Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile Lys Gly Leu Leu Asp 
        115                 120                 125


Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys Gly Lys Thr Pro Glu 
    130                 135                 140


Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp Phe Thr Glu Glu Glu 
145                 150                 155                 160


Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys Glu Glu Lys 
                165                 170


<210>  2916
<211>  1257
<212>  DNA
<213>  Homo sapiens

<400>  2916
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa gatttgggaa    480

tggatgatga aggagatgat gacccagttc ctctaccaaa tgtgaatgca gcaatattaa    540

aaaaggtcat tcagtggtgc acccaccaca aggatgaccc tcctcctcct gaagatgatg    600

agaacaaaga aaagcgaaca gatgatatcc ctgtttggga ccaagaattc ctgaaatata    660

ctttaaggaa aacaactgtc tctttacagg ctgcaaacta cttagacatc aaaggtttgc    720

ttgatgttac atgcaagact gttgccaata tgatcaaggg gaaaactcct gaggagattc    780

gcaagacctt caatatcaaa aatgacttta ctgaagagga ggaagcccag gtacgcaaag    840

agaaccagtg gtgtgaagag aagtgaaatg ttgtgcctga cactgtaaca ctgtaaggat    900

tgttccaaat actagttgca ctgctctgtt tataattgtt aatattagac aaacagtaga    960

caaatgcagc agcaagtcaa ttgtattagc agaatattgt cctcattgca tgtgtagttt   1020

gagcacagat cccaaacctt acggccaagt ttcttctagt atgatggaaa gtttcttttt   1080

tctttgctct gaataaaact gaactgtggg ttctctataa gtggcatttt gggctttccc   1140

tcttttttgt aaagcaatgt ctgcctagtt tattgtccag ttaactttag tgacctttta   1200

aaagttggca ttgtaaataa aacaacttgc aaaaaagttt tctggaatag aattaac      1257


<210>  2917
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  2917

Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Tyr Thr 
                85                  90                  95


Leu Arg Lys Thr Thr Val Ser Leu Gln Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp 
    130                 135                 140


Phe Thr Glu Glu Glu Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys 
145                 150                 155                 160


Glu Glu Lys 



<210>  2918
<211>  927
<212>  DNA
<213>  Homo sapiens

<400>  2918
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa gatttgggaa    480

tggatgatga aggagatgat gacccagttc ctctaccaaa tgtgaatgca gcaatattaa    540

aaaaggtcat tcagtggtgc acccaccaca aggatgaccc tcctcctcct gaagatgatg    600

agaacaaaga aaagcgaaca gatgatatcc ctgtttggga ccaagaattc ctgaaagttg    660

accaaggaac actttttgaa ctcattctgg ctgcaaacta cttagacatc aaaggtttgc    720

ttgatgttac atgcaagact gttgccaata tgatcaaggg gaaaactcct gaggagattc    780

gcaagacctt caatatcaaa aatgagcttt ccctcttttt tgtaaagcaa tgtctgccta    840

gtttattgtc cagttaactt tagtgacctt ttaaaagttg gcattgtaaa taaaacaact    900

tgcaaaaaag ttttctggaa tagaatt                                        927


<210>  2919
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  2919

Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95


Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Glu 
    130                 135                 140


Leu Ser Leu Phe Phe Val Lys Gln Cys Leu Pro Ser Leu Leu Ser Ser 
145                 150                 155                 160


<210>  2920
<211>  274
<212>  DNA
<213>  Homo sapiens

<400>  2920
ctgtaacact gtaaggattg ttccaaatac tagttgcact gctctgttta taattgttaa     60

tattagacaa acagtagaca aattatgatg gaaagtttct tttttctttg ctctgaataa    120

aactgaactg tgggttctct ataagtggca ttttgggctt tccctctttt ttgtaaagca    180

atgtctgcct agtttattgt ccagttaact ttagtgacct tttaaaagtt ggcattgtaa    240

ataaaacaac ttgcaaaaaa gttttctgga atag                                274


<210>  2921
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  2921

Trp Lys Val Ser Phe Phe Phe Ala Leu Asn Lys Thr Glu Leu Trp Val 
1               5                   10                  15


Leu Tyr Lys Trp His Phe Gly Leu Ser Leu Phe Phe Val Lys Gln Cys 
            20                  25                  30


Leu Pro Ser Leu Leu Ser Ser 
        35


<210>  2922
<211>  2546
<212>  DNA
<213>  Homo sapiens

<400>  2922
aaaacaaaaa cctttcgctg gccaggcaca gtggctcata gctgtaatcc caacactttg     60

ggagggcaag gtgggtgaat tgcttgagtt caggagtttg caacatgatg aaaccttatc    120

tctacaaaaa caaaatacaa aaatgagcca ggtgtggtgg catgcacctg tagttgcagc    180

tacttgggag gctgaggtgg gaggatcgct taagcacagg aggtcgagtg agccatgatc    240

gcggcactgc attccagcct gggtgacaca gtgagatctt gtctcaaaaa caaacaaaca    300

accctttgct tggcttttcc ttattgaaat tgttctttct tttttttttt ttggatcctg    360

gcaatgtttc ttggctctgc cattttctct cagcattgtt tactcctcca acattttgct    420

atgaaaaagt tttagccata cagaaaaatg gaaagaatta cacagtagac aaccatgtag    480

ccactgccta gattctacaa ctgaaaacac tttcagtatt gattttggtc tttatgctgg    540

tatgtatagt ctaagtaatc agcttcctga aactttatgg agtaattatt ctcctattaa    600

ggaaattttg gggcttttcc tgctttgttc ctacaccaaa tagtctcaca catgtgtcta    660

gggtatttgg aatttgctgg ttacaatata tgtacatatt cagcttttct gaggagtgct    720

ggattagctt tcaaaggggt tataccaatt tatactctct agaagagttt gtgtttcctt    780

tccactattg cccaacaatt agtatcagtt tcttgatttt ttttcaatct agagaagtat    840

ctgtagtgtt agttttgctt ctagtaaagt tgagcgttcc ttatgtttgg ctattcagat    900

ttcatttatt ggctgtacat attaacccat ttctctttaa tgatttttga aagattttat    960

attctctcag ctaatcattg ttgtacatat tgcaggtatc ttccagtcat tgtcctaact   1020

tttctttttg catagaagct ttttaatgta gtcaagtaca gtactctgtc tgcatggctt   1080

gcttttatct aataagatct tctcccttct agggttataa tgattcttca agcttcattt   1140

ttgtttttca agcttggctg ttaatggctc aagtcaacct ctagctagtt attattccaa   1200

tatagggata agttgtccca gcagtggaat gagtaccttg tgacaaagtg ccacagagga   1260

atgaactttt gttgttgtag gtcattcagt ggtgcaccca ccacaaggat gaccctcctc   1320

ctcctgaaga tgatgagaac aaagaaaagc gaacagatga tatccctgtt tgggaccaag   1380

aattcctgaa agttgaccaa ggaacacttt ttgaactcat tctggctgca aactacttag   1440

acatcaaagg tttgcttgat gttacatgca agactgttgc caatatgatc aaggggaaaa   1500

ctcctgagga gattcgcaag accttcaata tcaaaaatga ctttactgaa gaggaggaag   1560

cccaggtagg tagcacacag ttttgtcttt gatcacatgc tcttaaaaag ggagtaacac   1620

ctataacatg ccagcaaaag aggtgactgt atcaagtagt cttgatactt tagggataat   1680

atgtacttaa tgtgtcttaa acatactctt actgttctgt ctttatgaat ctgaacactt   1740

agatgatact gcattttaag cataagaaca attagttttc aatgagaaga gctcttgtta   1800

atgtattaac agttactagt tttggcacct gcaactttct gtatagacca tacatatctg   1860

acatcagaaa agcaggccct agagagaagt atatactagg gtactttaga gcaacttaat   1920

gaggggagga aatgaaagaa tagatcagaa tgattttgtt gacatgacta cagactgaaa   1980

taatgtgaat gaattaactg aatttgctct gtcaacttta gtaaattgcc cattgccttt   2040

gctttgttca taatttcagc agggcagaat aaaaaccatg ggaggcaaag aaaggaaatc   2100

cggaaatata gtcttaacct ggtgttgttc taattttcca tctgttcttc tgactcaact   2160

cactggctat cgatgaatca gtaggtagta tttataagtc ttaggaaaga ctactcaagt   2220

taaggtactt ccctatatcc atctctttta ggtacgcaaa gagaaccagt ggtgtgaaga   2280

gaagtgaaat gttgtgcctg acactgtaac actgtaagga ttgttccaaa tactagttgc   2340

actgctctgt ttataattgt taatattaga caaacagtag acaaatgcag cagcaagtca   2400

attgtattag cagaatattg tcctcattgc atgtgtagtt tgagcacaga tcccaaacct   2460

tacggccaag tttcttctag tatgatggaa agtttctttt ttctttgctc tgaataaaac   2520

tgaactgtgg gttctctata agtggc                                        2546


<210>  2923
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  2923

Met Tyr Ile Phe Ser Phe Ser Glu Glu Cys Trp Ile Ser Phe Gln Arg 
1               5                   10                  15


Gly Tyr Thr Asn Leu Tyr Ser Leu Glu Glu Phe Val Phe Pro Phe His 
            20                  25                  30


Tyr Cys Pro Thr Ile Ser Ile Ser Phe Leu Ile Phe Phe Gln Ser Arg 
        35                  40                  45


Glu Val Ser Val Val Leu Val Leu Leu Leu Val Lys Leu Ser Val Pro 
    50                  55                  60


Tyr Val Trp Leu Phe Arg Phe His Leu Leu Ala Val His Ile Asn Pro 
65                  70                  75                  80


Phe Leu Phe Asn Asp Phe 
                85


<210>  2924
<211>  910
<212>  DNA
<213>  Homo sapiens

<400>  2924
gttgtcgacc ctgttcttcg ggagacccta ccaggttccg ttcacctgcc ccgcccccga     60

ctcagcgagg cctcctctgg ccgggcgtcc tcacggcgct ccataaacat aaatgagcat    120

attctgatgt actctttgga tctgaactca tcttcacaga tgccttcaat taagttgcag    180

agttctgatg gagagatatt tgaagttgat gtggaaattg ccaaacaatc tgtgactatt    240

aagaccatgt tggaagattt gggaatggat gatgaaggag atgatgaccc agttcctcta    300

ccaaatgtga atgcagcaat attaaaaaag gtcattcagt ggtgcaccca ccacaaggat    360

gaccctcctc ctcctgaaga tgatgagaac aaagaaaagc gaacagatga tatccctgtt    420

tgggaccaag aattcctgaa agttgaccaa ggaacacttt ttgaactcat tctggctgca    480

aactacttag acatcaaagg tttgcttgat gttacatgca agactgttgc caatatgatc    540

aaggggaaaa ctcctgagga gattcgcaag accttcaata tcaaaaatga ctttactgaa    600

gaggaggaag cccaggtacg caaagagaac cagtggtgtg aagagaagtg aaatgttgtg    660

cctgacactg taacactgta aggattgttc caaatactag ttgcactgct ctgtttataa    720

ttgttaatat tagacaaaca gtagacaaat gcagcagcaa gtcaattgta ttagcagaat    780

attgtcctca ttgcatgtgt agtttgagca cagatcccaa accttacggc caagtttctt    840

ctagtatgat ggaaagtttc ttttttcttt gctctgaata aaactgaact gtgggttctc    900

tataagtggc                                                           910


<210>  2925
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  2925

Met Tyr Ser Leu Asp Leu Asn Ser Ser Ser Gln Met Pro Ser Ile Lys 
1               5                   10                  15


Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val Asp Val Glu Ile Ala 
            20                  25                  30


Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu Asp Leu Gly Met Asp 
        35                  40                  45


Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro Asn Val Asn Ala Ala 
    50                  55                  60


Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His His Lys Asp Asp Pro 
65                  70                  75                  80


Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys Arg Thr Asp Asp Ile 
                85                  90                  95


Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp Gln Gly Thr Leu Phe 
            100                 105                 110


Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile Lys Gly Leu Leu Asp 
        115                 120                 125


Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys Gly Lys Thr Pro Glu 
    130                 135                 140


Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp Phe Thr Glu Glu Glu 
145                 150                 155                 160


Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys Glu Glu Lys 
                165                 170


<210>  2926
<211>  1178
<212>  DNA
<213>  Homo sapiens

<400>  2926
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccacataa atgagcatat tctgatgtac tctttggatc tgaactcatc    420

ttcacagatg ccttcaatta agttgcagag ttctgatgga gagatatttg aagttgatgt    480

ggaaattgcc aaacaatctg tgactattaa gaccatgttg gaagatttgg gaatggatga    540

tgaaggagat gatgacccag ttcctctacc aaatgtgaat gcagcaatat taaaaaaggt    600

cattcagtgg tgcacccacc acaaggatga ccctcctcct cctgaagatg atgagaacaa    660

agaaaagcga acagatgata tccctgtttg ggaccaagaa ttcctgaaag ttgaccaagg    720

aacacttttt gaactcattc tggctgcaaa ctacttagac atcaaaggtt tgcttgatgt    780

tacatgcaag actgttgcca atatgatcaa ggggaaaact cctgaggaga ttcgcaagac    840

cttcaatatc aaaaatgact ttactgaaga ggaggaagcc caggtacgca aagagaacca    900

gtggtgtgaa gagaagtgaa atgttgtgcc tgacactgta acactgtaag gattgttcca    960

aatactagtt gcactgctct gtttataatt gttaatatta gacaaacagt agacaaatgc   1020

agcagcaagt caattgtatt agcagaatat tgtcctcatt gcatgtgtag tttgagcaca   1080

gatcccaaac cttacggcca agtttcttct agtatgatgg aaagtttctt ttttctttgc   1140

tctgaataaa actgaactgt gggttctcta taagtggc                           1178


<210>  2927
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  2927

Met Tyr Ser Leu Asp Leu Asn Ser Ser Ser Gln Met Pro Ser Ile Lys 
1               5                   10                  15


Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val Asp Val Glu Ile Ala 
            20                  25                  30


Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu Asp Leu Gly Met Asp 
        35                  40                  45


Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro Asn Val Asn Ala Ala 
    50                  55                  60


Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His His Lys Asp Asp Pro 
65                  70                  75                  80


Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys Arg Thr Asp Asp Ile 
                85                  90                  95


Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp Gln Gly Thr Leu Phe 
            100                 105                 110


Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile Lys Gly Leu Leu Asp 
        115                 120                 125


Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys Gly Lys Thr Pro Glu 
    130                 135                 140


Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp Phe Thr Glu Glu Glu 
145                 150                 155                 160


Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys Glu Glu Lys 
                165                 170


<210>  2928
<211>  1811
<212>  DNA
<213>  Homo sapiens

<400>  2928
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa gatttgggaa    480

tggatgatga aggagatgat gacccagttc ctctaccaaa tgtgaatgca gcaatattaa    540

aaaaggtcat tcagtggtgc acccaccaca aggatgaccc tcctcctcct gaagatgatg    600

agaacaaaga aaagcgaaca gatgatatcc ctgtttggga ccaagaattc ctgaaagttg    660

accaaggaac actttttgaa ctcattctgg ctgcaaacta cttagacatc aaaggtttgc    720

ttgatgttac atgcaagact gttgccaata tgatcaaggg gaaaactcct gaggagattc    780

gcaagacctt caatatcaaa aatgacttta ctgaagagga ggaagcccag gtaggtagca    840

cacagttttg tctttgatca catgctctta aaaagggagt aacacctata acatgccagc    900

aaaagaggtg actgtatcaa gtagtcttga tactttaggg ataatatgta cttaatgtgt    960

cttaaacata ctcttactgt tctgtcttta tgaatctgaa cacttagatg atactgcatt   1020

ttaagcataa gaacaattag ttttcaatga gaagagctct tgttaatgta ttaacagtta   1080

ctagttttgg cacctgcaac tttctgtata gaccatacat atctgacatc agaaaagcag   1140

gccctagaga gaagtatata ctagggtact ttagagcaac ttaatgaggg gaggaaatga   1200

aagaatagat cagaatgatt ttgttgacat gactacagac tgaaataatg tgaatgaatt   1260

aactgaattt gctctgtcaa ctttagtaaa ttgcccattg cctttgcttt gttcataatt   1320

tcagcagggc agaataaaaa ccatgggagg caaagaaagg aaatccggaa atatagtctt   1380

aacctggtgt tgttctaatt ttccatctgt tcttctgact caactcactg gctatcgatg   1440

aatcagtagg tagtatttat aagtcttagg aaagactact caagttaagg tacttcccta   1500

tatccatctc ttttaggtac gcaaagagaa ccagtggtgt gaagagaagt gaaatgttgt   1560

gcctgacact gtaacactgt aaggattgtt ccaaatacta gttgcactgc tctgtttata   1620

attgttaata ttagacaaac agtagacaaa tgcagcagca agtcaattgt attagcagaa   1680

tattgtcctc attgcatgtg tagtttgagc acagatccca aaccttacgg ccaagtttct   1740

tctagtatga tggaaagttt cttttttctt tgctctgaat aaaactgaac tgtgggttct   1800

ctataagtgg c                                                        1811


<210>  2929
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  2929

Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95


Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp 
    130                 135                 140


Phe Thr Glu Glu Glu Glu Ala Gln Val Gly Ser Thr Gln Phe Cys Leu 
145                 150                 155                 160


<210>  2930
<211>  1125
<212>  DNA
<213>  Homo sapiens

<400>  2930
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa gatttgggaa    480

tggatgatga aggagatgat gacccagttc ctctaccaaa tgtgaatgca gcaatattaa    540

aaaaggtcat tcagtggtgc acccaccaca aggatgaccc tcctcctcct gaagatgatg    600

agaacaaaga aaagcgaaca gatgatatcc ctgtttggga ccaagaattc ctgaaagttg    660

accaaggaac actttttgaa ctcattctgg ctgcaaacta cttagacatc aaaggtttgc    720

ttgatgttac atgcaagact gttgccaata tgatcaaggg gaaaactcct gaggagattc    780

gcaagacctt caatatcaaa aatgacttta ctgaagagga ggaagcccag gtacgcaaag    840

agaaccagtg gtgtgaagag aagtgaaatg ttgtgcctga cactgtaaca ctgtaaggat    900

tgttccaaat actagttgca ctgctctgtt tataattgtt aatattagac aaacagtaga    960

caaatgcagc agcaagtcaa ttgtattagc agaatattgt cctcattgca tgtgtagttt   1020

gagcacagat cccaaacctt acggccaagt ttcttctagt atgatggaaa gtttcttttt   1080

tctttgctct gaataaaact gaactgtggg ttctctataa gtggc                   1125


<210>  2931
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  2931

Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95


Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp 
    130                 135                 140


Phe Thr Glu Glu Glu Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys 
145                 150                 155                 160


Glu Glu Lys 



<210>  2932
<211>  1213
<212>  DNA
<213>  Homo sapiens

<400>  2932
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa gtcactgttc    480

atcaagtacc tattgaatga agagtatgtt gtgctcacta aaaaaaactg aaagcaatcc    540

aagtgtccct aaaaggcaga tttgggaatg gatgatgaag gagatgatga cccagttcct    600

ctaccaaatg tgaatgcagc aatattaaaa aaggtcattc agtggtgcac ccaccacaag    660

gatgaccctc ctcctcctga agatgatgag aacaaagaaa agcgaacaga tgatatccct    720

gtttgggacc aagaattcct gaaagttgac caaggaacac tttttgaact cattctggct    780

gcaaactact tagacatcaa aggtttgctt gatgttacat gcaagactgt tgccaatatg    840

atcaagggga aaactcctga ggagattcgc aagaccttca atatcaaaaa tgactttact    900

gaagaggagg aagcccaggt acgcaaagag aaccagtggt gtgaagagaa gtgaaatgtt    960

gtgcctgaca ctgtaacact gtaaggattg ttccaaatac tagttgcact gctctgttta   1020

taattgttaa tattagacaa acagtagaca aatgcagcag caagtcaatt gtattagcag   1080

aatattgtcc tcattgcatg tgtagtttga gcacagatcc caaaccttac ggccaagttt   1140

cttctagtat gatggaaagt ttcttttttc tttgctctga ataaaactga actgtgggtt   1200

ctctataagt ggc                                                      1213


<210>  2933
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  2933

Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro Asn Val Asn 
1               5                   10                  15


Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His His Lys Asp 
            20                  25                  30


Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys Arg Thr Asp 
        35                  40                  45


Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp Gln Gly Thr 
    50                  55                  60


Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile Lys Gly Leu 
65                  70                  75                  80


Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys Gly Lys Thr 
                85                  90                  95


Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp Phe Thr Glu 
            100                 105                 110


Glu Glu Glu Ala Gln Val Arg Lys Glu Asn Gln Trp Cys Glu Glu Lys 
        115                 120                 125


<210>  2934
<211>  1317
<212>  DNA
<213>  Homo sapiens

<400>  2934
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa gatttgggaa    480

tggatgatga aggagatgat gacccagttc ctctaccaaa tgtgaatgca gcaatattaa    540

aaaaggtcat tcagtggtgc acccaccaca aggatgaccc tcctcctcct gaagatgatg    600

agaacaaaga aaagcgaaca gatgatatcc ctgtttggga ccaagaattc ctgaaagttg    660

accaaggaac actttttgaa ctcattctgg ctgcaaacta cttagacatc aaaggtttgc    720

ttgatgttac atgcaagact gttgccaata tgatcaaggg gaaaactcct gaggagattc    780

gcaagacctt caatatcaaa aatgacttta ctgaagagga ggaagcccag cagggcagaa    840

taaaaaccat gggaggcaaa gaaaggaaat ccggaaatat agtcttaacc tggtgttgtt    900

ctaattttcc atctgttctt ctgactcaac tcactggcta tcgatgaatc agtaggtagt    960

atttataagt cttaggaaag actactcaag ttaaggtact tccctatatc catctctttt   1020

aggtacgcaa agagaaccag tggtgtgaag agaagtgaaa tgttgtgcct gacactgtaa   1080

cactgtaagg attgttccaa atactagttg cactgctctg tttataattg ttaatattag   1140

acaaacagta gacaaatgca gcagcaagtc aattgtatta gcagaatatt gtcctcattg   1200

catgtgtagt ttgagcacag atcccaaacc ttacggccaa gtttcttcta gtatgatgga   1260

aagtttcttt tttctttgct ctgaataaaa ctgaactgtg ggttctctat aagtggc      1317


<210>  2935
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  2935

Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95


Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp 
    130                 135                 140


Phe Thr Glu Glu Glu Glu Ala Gln Gln Gly Arg Ile Lys Thr Met Gly 
145                 150                 155                 160


Gly Lys Glu Arg Lys Ser Gly Asn Ile Val Leu Thr Trp Cys Cys Ser 
                165                 170                 175


Asn Phe Pro Ser Val Leu Leu Thr Gln Leu Thr Gly Tyr Arg 
            180                 185                 190


<210>  2936
<211>  1081
<212>  DNA
<213>  Homo sapiens

<400>  2936
gacctttcta ggccagtcgg ggtccggcac ccagttgacg agacagcgcg gcgctttcag     60

agctggggag aggcgaaaac tcttccggcc ccccgatccc ccggccagcc gcccccggca    120

gctccttgcc gcctcccggc ctgggcccgc ccagccgttc tcggcctgcc gtcaggcgat    180

ctcggcggcc agcccagccg cgatgtgacg ccgcgcgccc cggggtcctc ggcgcctgcg    240

ccctctccta taaagcagac gccgcgccgc gctgcgacgc tgtagtggct tcgtcttcgg    300

tttttctctt ccttcgctaa cgcctcccgg ctctcgtcag cctcccgccg gccgtctcct    360

taacaccgaa caccatgcct tcaattaagt tgcagagttc tgatggagag atatttgaag    420

ttgatgtgga aattgccaaa caatctgtga ctattaagac catgttggaa ggtaagttca    480

ttggaaaacc tgggtgggag gaaatgtgta atttgagata gtttgtgaat atcaaattta    540

tatgagcagc agcctgtcat aaggtgcttg agagtatgaa gaggtaaagt ttacattttt    600

ttctttataa cttacatttt tctgatacag gtcatccttt ctgcattgtc tgaattagtg    660

agggtcgttc tctcattaaa tggataaaat cataaggtaa aataaacatt gaagtgattg    720

ccaagcctta ggcaatggtt aatttctgtt caagtaaatt tgaattcata agttccagtg    780

atagaaatta aggtctttgg aaaagagata ccgtcctata atggtggctg aatagaacac    840

cttatttcag tggagggagt gagctctgtg gattgctgtg tagattttat ttattgattg    900

atttatttga gacagagtct cactcttgtc caggctggag tgcagtgatg cagtcacggc    960

tcactgcagc ctcaaccttc tgggctcagt cagtcttccc acctcagcct tccgaataac   1020

tgggactaca ggcacgtgcc accacatcca gctgattttt ttgagacgga tttttttgct   1080

c                                                                   1081


<210>  2937
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  2937

Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30


Gly Lys Phe Ile Gly Lys Pro Gly Trp Glu Glu Met Cys Asn Leu Arg 
        35                  40                  45


<210>  2938
<211>  4227
<212>  DNA
<213>  Homo sapiens

<400>  2938
tttttttttt taaagtacta aaaaaaaaac aagttttgta attaggggga aaataaatac     60

atgtgtacct tacaggttgt ataaagtaca ggagattatt aagtcatcca gaaaaaaagc    120

attaacattt cttaagcccc tttggcaggg gtgggaatga gtagagattt ttttctctct    180

tgagtgaagt aacatttagt tgaattgagg gagtaaagta agatttttgt ctccttttcc    240

ttgcagggat ataactggtg ccatgaccgg aatgtagtaa cgattttcag tgctccaaac    300

tattgttatc gttgtggtaa ccaagctgca atcatggaac ttgacgatac tctaaaatac    360

tctttcttgc agtttgaccc agcacctcgt agaggcgagc cacatgttac tcgtcgtacc    420

ccagactact tcctgtaatg aaattttaaa cttgtacagt attgccatga accatatatc    480

gacctaatgg aaatgggaag agcaacagta actccaaagt gtcagaaaat agttaacatt    540

caaaaaactt gttttcacat ggaccaaaag atgtgccata taaaaataca aagcctcttg    600

tcatcaacag ccgtgaccac tttagaatga accagttcat tgcatgctga agcgacattg    660

ttggtcaaga aaccagtttc tggcatagcg ctatttgtag ttacttttgc tttctctgag    720

agactgcaga taataagatg taaacattaa cacctcgtga atacaattta acttccattt    780

agctatagct ttactcagca tgactgtaga taaggatagc agcaaacaat cattggagct    840

taatgaacat ttttaaaaat aattaccaag gcctcccttc tacttgtgag ttttgaaatt    900

gttcttttta ttttcaggga taccgtttaa tttaattata tgatttgtct gcactcagtt    960

tattccctac tcaaatctca gccccatgtt gttctttgtt attgtcagaa cctggtgagt   1020

tgttttgaac agaactgttt tttccccttc ctgtaagacg atgtgactgc acaagagcac   1080

tgcagtgttt ttcataataa acttgtgaac taagaactga gaaggtcaaa ttttaattgt   1140

atcaatgggc aagactggtg ctgtttatta aaaaagttaa atcaattgag taaattttag   1200

aatttgtaga cttgtaggta aaataaaaat caagggcact acataacctc tctggtaact   1260

ccttgacatt cttcagatta acttcaggat ttatttgtat ttcacatatt acaatttgtc   1320

acattgttgg tgtgcacttt gtgggttctt cctgcatatt aacttgtttg taagaaagga   1380

aatctgtgct gcttcagtaa gacttaattg taaaaccata taacttgaga tttaagtctt   1440

tgggttttgt tttaataaaa cagcatgttt tcaggtagag cttaaactaa atgatgtgtt   1500

tacttagtgc agtttctggt tatgaatatt atattgctat gtgtatatta tatggactct   1560

ttaaaatgat tgacagattg gcaaattctt aaatctttgt acattgttga gtcatatgtt   1620

cttagagtta aatttgtctc agataagaaa gtgttaaagc attagcctgt gtcaagttct   1680

ttgagtgata ctagtgaaac caaatagaaa actattgttg gatcatgatt tagtcttatg   1740

tacattcacc cgaagacaaa aatggtactt aaagtggcag tgttcaacat ttaatgagtt   1800

tttccccttt tatccttcga ataggattag atgtttaaaa aaaagttctt ctgtgggaac   1860

taatatttga tattttaacc taccagagta aacaggaaca cttaatcata cttgtgagtg   1920

tagtaaataa aagttttctt gctttgtgct gtgttgaatc tggaaccaac agggaagtta   1980

tagcatatcc cctttctaaa atgcttgagg aacacataca taccgaatgt cttttctgat   2040

ctaattgata gtatttttag tggcttgtgg agttaatttt ccaaagcaaa aggccattag   2100

ggtttctaca tttcatttca tttcattctt ttctttcaca agaaatacat tctctgtgtg   2160

tctttttgtt gctctgtcac tctatgccct ttctctccga ctgaacaaat agcttatcca   2220

tgtgcagtgg ttttaatacc caaacaatct agacaccaag cagctatttt ttccggtcct   2280

gtgatatcag aattgaccaa ggaatacgta tattgtaatt gacacgtggt ggtatcttcc   2340

aggtacaaat tctctaaatt ttgtggttag cagaatggga cttgtgataa gaatagcttg   2400

gttttagcat aactagggtt taaaataatt gtttaattat agagactgac cgggctttgg   2460

ccatctaaac tggaaagtgt tagtacccta ccttcttttg aaaatggcta tggtaaggaa   2520

aatgtgttag taaattatgt attttcttga aaaatacata attatggttg gatgggaatc   2580

actaagttgg gtgttaactg atgtctcaat tagtaacatt aggattttca ttaataaacc   2640

taaaaagctt tccctaagaa caggcctggc acagtggctc atgcctgtaa tcccagcact   2700

ttgggagacc agggtgggtg gatcccttga ggtcaggagt tgaagagcag cctggccaac   2760

atggcaaaac cccatctcta caaaaaatat gaaaatcagc cgggcttggt ggcataccat   2820

agtcccagct acttgggagg ctgaggtgag aggatcgcct gagcccagga gatggaggtt   2880

gcagtgggct gagattgtgc cactgtactc cagtctgggt gacagagcca gaccctgtct   2940

caaaaataaa gaggattctg agtttgtata gtgagggctt gcagaaattt tgaaacttat   3000

tttgtaagtt tacaatgaat ttgtacatga tgtgctcatg tcttgggttg agtatcctag   3060

acatgatttt ttcatttgct gcatattaaa catttgttgg ttgtagtcgg tatttcttaa   3120

atagaagttt gtcaatatta gattagtttc aagaaggact tagctcagga aaaggatagt   3180

tatttctgtg gttctcagct ttgatgccta cagagattct gatttaaatt gctggaggag   3240

ggcccaggca tacatttttt aagtttccca agtgattcta atttacatct agggttaaaa   3300

acagccaggc gcggtggctc atgcctgtaa tcccagcact tggggaggcc ggggtgggtg   3360

gatcacctga tgtcaggaga tcgagaccag cctggccagc gtggtgaaac cccatctcta   3420

ttaaaaatac aaaactgacc ggtgtggtgg caggagcctg taatcccagc tacttgggag   3480

gctgaggcag gagaatcact tgaactcagg aggaggaggt tacagtgagc ccagatcgtg   3540

ccattgcact ccagcctggg caaaaagagc aaaactccat ctcaaaaaac aaaaacacct   3600

cactgctgtt tcctaagtac atacttaaga aaattgggat acatggtggt ggttcatgga   3660

tgttgataag gaattaaaat gtaccgtgcg actctctgtt tcagtggtga cttttacctg   3720

tttagtataa atattccttt gcttccaacc ataaatgtgt tcttagaaat gggcctatag   3780

tttagtaacc tatagtttgg taataggctt gtttgttttc agatggattt tggttctgtg   3840

agctaaagct attttgcatt aaagccttcg tcctcacaca ttgttttgac atatttctag   3900

tcttcataaa cttttttaat ttagattttt ttcccttcac aagtatacat ctgttttagc   3960

aaatagcctt atgaaggttg tagatgtatt attttgggca tgcctggtga tttctatatt   4020

ttttccaatt acatttaaag ctttatgttt taggaatata agtacatttt atttctactt   4080

tttattatat atatttaatt gcacaagtac tactgtctag aaaaaaatgg gatgttgcta   4140

acacagcatt gttggcttgt aggcagtgct gtcctgtaaa tagattgaaa tgtattttta   4200

tcagctggta tataaatttg aggaaag                                       4227


<210>  2939
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  2939

Met Glu Leu Asp Asp Thr Leu Lys Tyr Ser Phe Leu Gln Phe Asp Pro 
1               5                   10                  15


Ala Pro Arg Arg Gly Glu Pro His Val Thr Arg Arg Thr Pro Asp Tyr 
            20                  25                  30


Phe Leu 



<210>  2940
<211>  5503
<212>  DNA
<213>  Homo sapiens

<400>  2940
agaggtgggg gtggttaatc caagcggcca ctcgctgccc gttcctgccc ccaaagatga     60

cggaaaccca cacgattaca gagccgcagc accccagatg agccacgggg tcgcaattct    120

cgtttccgtg atcggactgc caggccccag gtgaggagct gagttcatca ccagagcggc    180

cttcccaggg gaaccagtta caggctgcca gtggccccgg cttccatccg gtctgcgcct    240

gcgcgcggcc caagccctcg cctctcctgg aatagtgctc agggattagt ccggttcgcc    300

gctgtgcgca ctgcgcatgc tccagctcca tccttccctt cccccaccac cccgccctcc    360

gggagccacg cccaaaaagt caaggcgctt cagttaccag ccggctacgt cgcgcctgcg    420

ctttgacccc cagtttgcgc cccaactccg gtcgtgcggc cgcccgggga gggctctgca    480

gttgcgcagc ttgctccccg gcccttttcc cctccgctcc ccgccgcctc ctgacgccgg    540

gcgtgacgtc accacgcccg gcggccgcca ttacagagag ccgagctctg gagcctcagc    600

gagcggagga ggaggcgcag cggccgacgg ccgagtactg cggtgagagc cagcgggcca    660

gcgccagcct caacagccgc cagaagtaca cgaggaaccg gcggcggcgt gtgcgtgtag    720

gcccgtgtgc gggcggcggc gcgggagcag cgcggagcgg cagccggctg gggcgggtgg    780

catcatggac gagaaggtgt tcaccaagga gctggaccag tggatcgagc agctgaacga    840

gtgcaagcag ctgtccgagt cccaggtcaa gagcctctgc gagaaggcta aagaaatcct    900

gacaaaagaa tccaacgtgc aagaggttcg atgtccagtt actgtctgtg gagatgtgca    960

tgggcaattt catgatctca tggaactgtt tagaattggt ggcaaatcac cagatacaaa   1020

ttacttgttt atgggagatt atgttgacag aggatattat tcagttgaaa cagttacact   1080

gcttgtagct cttaaggttc gttaccgtga acgcatcacc attcttcgag ggaatcatga   1140

gagcagacag atcacacaag tttatggttt ctatgatgaa tgtttaagaa aatatggaaa   1200

tgcaaatgtt tggaaatatt ttacagatct ttttgactat cttcctctca ctgccttggt   1260

ggatgggcag atcttctgtc tacatggtgg tctctcgcca tctatagata cactggatca   1320

tatcagagca cttgatcgcc tacaagaagt tccccatgag ggtccaatgt gtgacttgct   1380

gtggtcagat ccagatgacc gtggtggttg gggtatatct cctcgaggag ctggttacac   1440

ctttgggcaa gatatttctg agacatttaa tcatgccaat ggcctcacgt tggtgtctag   1500

agctcaccag ctagtgatgg agggatataa ctggtgccat gaccggaatg tagtaacgat   1560

tttcagtgct ccaaactatt gttatcgttg tggtaaccaa gctgcaatca tggaacttga   1620

cgatactcta aaatactctt tcttgcagtt tgacccagca cctcgtagag gcgagccaca   1680

tgttactcgt cgtaccccag actacttcct gtaatgaaat tttaaacttg tacagtattg   1740

ccatgaacca tatatcgacc taatggaaat gggaagagca acagtaactc caaagtgtca   1800

gaaaatagtt aacattcaaa aaacttgttt tcacatggac caaaagatgt gccatataaa   1860

aatacaaagc ctcttgtcat caacagccgt gaccacttta gaatgaacca gttcattgca   1920

tgctgaagcg acattgttgg tcaagaaacc agtttctggc atagcgctat ttgtagttac   1980

ttttgctttc tctgagagac tgcagataat aagatgtaaa cattaacacc tcgtgaatac   2040

aatttaactt ccatttagct atagctttac tcagcatgac tgtagataag gatagcagca   2100

aacaatcatt ggagcttaat gaacattttt aaaaataatt accaaggcct cccttctact   2160

tgtgagtttt gaaattgttc tttttatttt cagggatacc gtttaattta attatatgat   2220

ttgtctgcac tcagtttatt ccctactcaa atctcagccc catgttgttc tttgttattg   2280

tcagaacctg gtgagttgtt ttgaacagaa ctgttttttc cccttcctgt aagacgatgt   2340

gactgcacaa gagcactgca gtgtttttca taataaactt gtgaactaag aactgagaag   2400

gtcaaatttt aattgtatca atgggcaaga ctggtgctgt ttattaaaaa agttaaatca   2460

attgagtaaa ttttagaatt tgtagacttg taggtaaaat aaaaatcaag ggcactacat   2520

aacctctctg gtaactcctt gacattcttc agattaactt caggatttat ttgtatttca   2580

catattacaa tttgtcacat tgttggtgtg cactttgtgg gttcttcctg catattaact   2640

tgtttgtaag aaaggaaatc tgtgctgctt cagtaagact taattgtaaa accatataac   2700

ttgagattta agtctttggg ttttgtttta ataaaacagc atgttttcag gtagagctta   2760

aactaaatga tgtgtttact tagtgcagtt tctggttatg aatattatat tgctatgtgt   2820

atattatatg gactctttaa aatgattgac agattggcaa attcttaaat ctttgtacat   2880

tgttgagtca tatgttctta gagttaaatt tgtctcagat aagaaagtgt taaagcatta   2940

gcctgtgtca agttctttga gtgatactag tgaaaccaaa tagaaaacta ttgttggatc   3000

atgatttagt cttatgtaca ttcacccgaa gacaaaaatg gtacttaaag tggcagtgtt   3060

caacatttaa tgagtttttc cccttttatc cttcgaatag gattagatgt ttaaaaaaaa   3120

gttcttctgt gggaactaat atttgatatt ttaacctacc agagtaaaca ggaacactta   3180

atcatacttg tgagtgtagt aaataaaagt tttcttgctt tgtgctgtgt tgaatctgga   3240

accaacaggg aagttatagc atatcccctt tctaaaatgc ttgaggaaca catacatacc   3300

gaatgtcttt tctgatctaa ttgatagtat ttttagtggc ttgtggagtt aattttccaa   3360

agcaaaaggc cattagggtt tctacatttc atttcatttc attcttttct ttcacaagaa   3420

atacattctc tgtgtgtctt tttgttgctc tgtcactcta tgccctttct ctccgactga   3480

acaaatagct tatccatgtg cagtggtttt aatacccaaa caatctagac accaagcagc   3540

tattttttcc ggtcctgtga tatcagaatt gaccaaggaa tacgtatatt gtaattgaca   3600

cgtggtggta tcttccaggt acaaattctc taaattttgt ggttagcaga atgggacttg   3660

tgataagaat agcttggttt tagcataact agggtttaaa ataattgttt aattatagag   3720

actgaccggg ctttggccat ctaaactgga aagtgttagt accctacctt cttttgaaaa   3780

tggctatggt aaggaaaatg tgttagtaaa ttatgtattt tcttgaaaaa tacataatta   3840

tggttggatg ggaatcacta agttgggtgt taactgatgt ctcaattagt aacattagga   3900

ttttcattaa taaacctaaa aagctttccc taagaacagg cctggcacag tggctcatgc   3960

ctgtaatccc agcactttgg gagaccaggg tgggtggatc ccttgaggtc aggagttgaa   4020

gagcagcctg gccaacatgg caaaacccca tctctacaaa aaatatgaaa atcagccggg   4080

cttggtggca taccatagtc ccagctactt gggaggctga ggtgagagga tcgcctgagc   4140

ccaggagatg gaggttgcag tgggctgaga ttgtgccact gtactccagt ctgggtgaca   4200

gagccagacc ctgtctcaaa aataaagagg attctgagtt tgtatagtga gggcttgcag   4260

aaattttgaa acttattttg taagtttaca atgaatttgt acatgatgtg ctcatgtctt   4320

gggttgagta tcctagacat gattttttca tttgctgcat attaaacatt tgttggttgt   4380

agtcggtatt tcttaaatag aagtttgtca atattagatt agtttcaaga aggacttagc   4440

tcaggaaaag gatagttatt tctgtggttc tcagctttga tgcctacaga gattctgatt   4500

taaattgctg gaggagggcc caggcataca ttttttaagt ttcccaagtg attctaattt   4560

acatctaggg ttaaaaacag ccaggcgcgg tggctcatgc ctgtaatccc agcacttggg   4620

gaggccgggg tgggtggatc acctgatgtc aggagatcga gaccagcctg gccagcgtgg   4680

tgaaacccca tctctattaa aaatacaaaa ctgaccggtg tggtggcagg agcctgtaat   4740

cccagctact tgggaggctg aggcaggaga atcacttgaa ctcaggagga ggaggttaca   4800

gtgagcccag atcgtgccat tgcactccag cctgggcaaa aagagcaaaa ctccatctca   4860

aaaaacaaaa acacctcact gctgtttcct aagtacatac ttaagaaaat tgggatacat   4920

ggtggtggtt catggatgtt gataaggaat taaaatgtac cgtgcgactc tctgtttcag   4980

tggtgacttt tacctgttta gtataaatat tcctttgctt ccaaccataa atgtgttctt   5040

agaaatgggc ctatagttta gtaacctata gtttggtaat aggcttgttt gttttcagat   5100

ggattttggt tctgtgagct aaagctattt tgcattaaag ccttcgtcct cacacattgt   5160

tttgacatat ttctagtctt cataaacttt tttaatttag atttttttcc cttcacaagt   5220

atacatctgt tttagcaaat agccttatga aggttgtaga tgtattattt tgggcatgcc   5280

tggtgatttc tatatttttt ccaattacat ttaaagcttt atgttttagg aatataagta   5340

cattttattt ctacttttta ttatatatat ttaattgcac aagtactact gtctagaaaa   5400

aaatgggatg ttgctaacac agcattgttg gcttgtaggc agtgctgtcc tgtaaataga   5460

ttgaaatgta tttttatcag ctggtatata aatttgagga aag                     5503


<210>  2941
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  2941

Met Asp Glu Lys Val Phe Thr Lys Glu Leu Asp Gln Trp Ile Glu Gln 
1               5                   10                  15


Leu Asn Glu Cys Lys Gln Leu Ser Glu Ser Gln Val Lys Ser Leu Cys 
            20                  25                  30


Glu Lys Ala Lys Glu Ile Leu Thr Lys Glu Ser Asn Val Gln Glu Val 
        35                  40                  45


Arg Cys Pro Val Thr Val Cys Gly Asp Val His Gly Gln Phe His Asp 
    50                  55                  60


Leu Met Glu Leu Phe Arg Ile Gly Gly Lys Ser Pro Asp Thr Asn Tyr 
65                  70                  75                  80


Leu Phe Met Gly Asp Tyr Val Asp Arg Gly Tyr Tyr Ser Val Glu Thr 
                85                  90                  95


Val Thr Leu Leu Val Ala Leu Lys Val Arg Tyr Arg Glu Arg Ile Thr 
            100                 105                 110


Ile Leu Arg Gly Asn His Glu Ser Arg Gln Ile Thr Gln Val Tyr Gly 
        115                 120                 125


Phe Tyr Asp Glu Cys Leu Arg Lys Tyr Gly Asn Ala Asn Val Trp Lys 
    130                 135                 140


Tyr Phe Thr Asp Leu Phe Asp Tyr Leu Pro Leu Thr Ala Leu Val Asp 
145                 150                 155                 160


Gly Gln Ile Phe Cys Leu His Gly Gly Leu Ser Pro Ser Ile Asp Thr 
                165                 170                 175


Leu Asp His Ile Arg Ala Leu Asp Arg Leu Gln Glu Val Pro His Glu 
            180                 185                 190


Gly Pro Met Cys Asp Leu Leu Trp Ser Asp Pro Asp Asp Arg Gly Gly 
        195                 200                 205


Trp Gly Ile Ser Pro Arg Gly Ala Gly Tyr Thr Phe Gly Gln Asp Ile 
    210                 215                 220


Ser Glu Thr Phe Asn His Ala Asn Gly Leu Thr Leu Val Ser Arg Ala 
225                 230                 235                 240


His Gln Leu Val Met Glu Gly Tyr Asn Trp Cys His Asp Arg Asn Val 
                245                 250                 255


Val Thr Ile Phe Ser Ala Pro Asn Tyr Cys Tyr Arg Cys Gly Asn Gln 
            260                 265                 270


Ala Ala Ile Met Glu Leu Asp Asp Thr Leu Lys Tyr Ser Phe Leu Gln 
        275                 280                 285


Phe Asp Pro Ala Pro Arg Arg Gly Glu Pro His Val Thr Arg Arg Thr 
    290                 295                 300


Pro Asp Tyr Phe Leu 
305


<210>  2942
<211>  5423
<212>  DNA
<213>  Homo sapiens

<400>  2942
agaggtgggg gtggttaatc caagcggcca ctcgctgccc gttcctgccc ccaaagatga     60

cggaaaccca cacgattaca gagccgcagc accccagatg agccacgggg tcgcaattct    120

cgtttccgtg atcggactgc caggccccag gtgaggagct gagttcatca ccagagcggc    180

cttcccaggg gaaccagtta caggctgcca gtggccccgg cttccatccg gtctgcgcct    240

gcgcgcggcc caagccctcg cctctcctgg aatagtgctc agggattagt ccggttcgcc    300

gctgtgcgca ctgcgcatgc tccagctcca tccttccctt cccccaccac cccgccctcc    360

gggagccacg cccaaaaagt caaggcgctt cagttaccag ccggctacgt cgcgcctgcg    420

ctttgacccc cagtttgcgc cccaactccg gtcgtgcggc cgcccgggga gggctctgca    480

gttgcgcagc ttgctccccg gcccttttcc cctccgctcc ccgccgcctc ctgacgccgg    540

gcgtgacgtc accacgcccg gcggccgcca ttacagagag ccgagctctg gagcctcagc    600

gagcggagga ggaggcgcag cggccgacgg ccgagtactg cggtgagagc cagcgggcca    660

gcgccagcct caacagccgc cagaagtaca cgaggaaccg gcggcggcgt gtgcgtgtag    720

gcccgtgtgc gggcggcggc gcgggagcag cgcggagcgg cagccggctg gggcgggtgg    780

catcatggac gagaaggtgt tcaccaagga gctggaccag tggatcgagc agctgaacga    840

gtgcaagcag ctgtccgatt actgtctgtg gagatgtgca tgggcaattt catgatctca    900

tggaactgtt tagaattggt ggcaaatcac cagatacaaa ttacttgttt atgggagatt    960

atgttgacag aggatattat tcagttgaaa cagttacact gcttgtagct cttaaggttc   1020

gttaccgtga acgcatcacc attcttcgag ggaatcatga gagcagacag atcacacaag   1080

tttatggttt ctatgatgaa tgtttaagaa aatatggaaa tgcaaatgtt tggaaatatt   1140

ttacagatct ttttgactat cttcctctca ctgccttggt ggatgggcag atcttctgtc   1200

tacatggtgg tctctcgcca tctatagata cactggatca tatcagagca cttgatcgcc   1260

tacaagaagt tccccatgag ggtccaatgt gtgacttgct gtggtcagat ccagatgacc   1320

gtggtggttg gggtatatct cctcgaggag ctggttacac ctttgggcaa gatatttctg   1380

agacatttaa tcatgccaat ggcctcacgt tggtgtctag agctcaccag ctagtgatgg   1440

agggatataa ctggtgccat gaccggaatg tagtaacgat tttcagtgct ccaaactatt   1500

gttatcgttg tggtaaccaa gctgcaatca tggaacttga cgatactcta aaatactctt   1560

tcttgcagtt tgacccagca cctcgtagag gcgagccaca tgttactcgt cgtaccccag   1620

actacttcct gtaatgaaat tttaaacttg tacagtattg ccatgaacca tatatcgacc   1680

taatggaaat gggaagagca acagtaactc caaagtgtca gaaaatagtt aacattcaaa   1740

aaacttgttt tcacatggac caaaagatgt gccatataaa aatacaaagc ctcttgtcat   1800

caacagccgt gaccacttta gaatgaacca gttcattgca tgctgaagcg acattgttgg   1860

tcaagaaacc agtttctggc atagcgctat ttgtagttac ttttgctttc tctgagagac   1920

tgcagataat aagatgtaaa cattaacacc tcgtgaatac aatttaactt ccatttagct   1980

atagctttac tcagcatgac tgtagataag gatagcagca aacaatcatt ggagcttaat   2040

gaacattttt aaaaataatt accaaggcct cccttctact tgtgagtttt gaaattgttc   2100

tttttatttt cagggatacc gtttaattta attatatgat ttgtctgcac tcagtttatt   2160

ccctactcaa atctcagccc catgttgttc tttgttattg tcagaacctg gtgagttgtt   2220

ttgaacagaa ctgttttttc cccttcctgt aagacgatgt gactgcacaa gagcactgca   2280

gtgtttttca taataaactt gtgaactaag aactgagaag gtcaaatttt aattgtatca   2340

atgggcaaga ctggtgctgt ttattaaaaa agttaaatca attgagtaaa ttttagaatt   2400

tgtagacttg taggtaaaat aaaaatcaag ggcactacat aacctctctg gtaactcctt   2460

gacattcttc agattaactt caggatttat ttgtatttca catattacaa tttgtcacat   2520

tgttggtgtg cactttgtgg gttcttcctg catattaact tgtttgtaag aaaggaaatc   2580

tgtgctgctt cagtaagact taattgtaaa accatataac ttgagattta agtctttggg   2640

ttttgtttta ataaaacagc atgttttcag gtagagctta aactaaatga tgtgtttact   2700

tagtgcagtt tctggttatg aatattatat tgctatgtgt atattatatg gactctttaa   2760

aatgattgac agattggcaa attcttaaat ctttgtacat tgttgagtca tatgttctta   2820

gagttaaatt tgtctcagat aagaaagtgt taaagcatta gcctgtgtca agttctttga   2880

gtgatactag tgaaaccaaa tagaaaacta ttgttggatc atgatttagt cttatgtaca   2940

ttcacccgaa gacaaaaatg gtacttaaag tggcagtgtt caacatttaa tgagtttttc   3000

cccttttatc cttcgaatag gattagatgt ttaaaaaaaa gttcttctgt gggaactaat   3060

atttgatatt ttaacctacc agagtaaaca ggaacactta atcatacttg tgagtgtagt   3120

aaataaaagt tttcttgctt tgtgctgtgt tgaatctgga accaacaggg aagttatagc   3180

atatcccctt tctaaaatgc ttgaggaaca catacatacc gaatgtcttt tctgatctaa   3240

ttgatagtat ttttagtggc ttgtggagtt aattttccaa agcaaaaggc cattagggtt   3300

tctacatttc atttcatttc attcttttct ttcacaagaa atacattctc tgtgtgtctt   3360

tttgttgctc tgtcactcta tgccctttct ctccgactga acaaatagct tatccatgtg   3420

cagtggtttt aatacccaaa caatctagac accaagcagc tattttttcc ggtcctgtga   3480

tatcagaatt gaccaaggaa tacgtatatt gtaattgaca cgtggtggta tcttccaggt   3540

acaaattctc taaattttgt ggttagcaga atgggacttg tgataagaat agcttggttt   3600

tagcataact agggtttaaa ataattgttt aattatagag actgaccggg ctttggccat   3660

ctaaactgga aagtgttagt accctacctt cttttgaaaa tggctatggt aaggaaaatg   3720

tgttagtaaa ttatgtattt tcttgaaaaa tacataatta tggttggatg ggaatcacta   3780

agttgggtgt taactgatgt ctcaattagt aacattagga ttttcattaa taaacctaaa   3840

aagctttccc taagaacagg cctggcacag tggctcatgc ctgtaatccc agcactttgg   3900

gagaccaggg tgggtggatc ccttgaggtc aggagttgaa gagcagcctg gccaacatgg   3960

caaaacccca tctctacaaa aaatatgaaa atcagccggg cttggtggca taccatagtc   4020

ccagctactt gggaggctga ggtgagagga tcgcctgagc ccaggagatg gaggttgcag   4080

tgggctgaga ttgtgccact gtactccagt ctgggtgaca gagccagacc ctgtctcaaa   4140

aataaagagg attctgagtt tgtatagtga gggcttgcag aaattttgaa acttattttg   4200

taagtttaca atgaatttgt acatgatgtg ctcatgtctt gggttgagta tcctagacat   4260

gattttttca tttgctgcat attaaacatt tgttggttgt agtcggtatt tcttaaatag   4320

aagtttgtca atattagatt agtttcaaga aggacttagc tcaggaaaag gatagttatt   4380

tctgtggttc tcagctttga tgcctacaga gattctgatt taaattgctg gaggagggcc   4440

caggcataca ttttttaagt ttcccaagtg attctaattt acatctaggg ttaaaaacag   4500

ccaggcgcgg tggctcatgc ctgtaatccc agcacttggg gaggccgggg tgggtggatc   4560

acctgatgtc aggagatcga gaccagcctg gccagcgtgg tgaaacccca tctctattaa   4620

aaatacaaaa ctgaccggtg tggtggcagg agcctgtaat cccagctact tgggaggctg   4680

aggcaggaga atcacttgaa ctcaggagga ggaggttaca gtgagcccag atcgtgccat   4740

tgcactccag cctgggcaaa aagagcaaaa ctccatctca aaaaacaaaa acacctcact   4800

gctgtttcct aagtacatac ttaagaaaat tgggatacat ggtggtggtt catggatgtt   4860

gataaggaat taaaatgtac cgtgcgactc tctgtttcag tggtgacttt tacctgttta   4920

gtataaatat tcctttgctt ccaaccataa atgtgttctt agaaatgggc ctatagttta   4980

gtaacctata gtttggtaat aggcttgttt gttttcagat ggattttggt tctgtgagct   5040

aaagctattt tgcattaaag ccttcgtcct cacacattgt tttgacatat ttctagtctt   5100

cataaacttt tttaatttag atttttttcc cttcacaagt atacatctgt tttagcaaat   5160

agccttatga aggttgtaga tgtattattt tgggcatgcc tggtgatttc tatatttttt   5220

ccaattacat ttaaagcttt atgttttagg aatataagta cattttattt ctacttttta   5280

ttatatatat ttaattgcac aagtactact gtctagaaaa aaatgggatg ttgctaacac   5340

agcattgttg gcttgtaggc agtgctgtcc tgtaaataga ttgaaatgta tttttatcag   5400

ctggtatata aatttgagga aag                                           5423


<210>  2943
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  2943

Met Glu Leu Phe Arg Ile Gly Gly Lys Ser Pro Asp Thr Asn Tyr Leu 
1               5                   10                  15


Phe Met Gly Asp Tyr Val Asp Arg Gly Tyr Tyr Ser Val Glu Thr Val 
            20                  25                  30


Thr Leu Leu Val Ala Leu Lys Val Arg Tyr Arg Glu Arg Ile Thr Ile 
        35                  40                  45


Leu Arg Gly Asn His Glu Ser Arg Gln Ile Thr Gln Val Tyr Gly Phe 
    50                  55                  60


Tyr Asp Glu Cys Leu Arg Lys Tyr Gly Asn Ala Asn Val Trp Lys Tyr 
65                  70                  75                  80


Phe Thr Asp Leu Phe Asp Tyr Leu Pro Leu Thr Ala Leu Val Asp Gly 
                85                  90                  95


Gln Ile Phe Cys Leu His Gly Gly Leu Ser Pro Ser Ile Asp Thr Leu 
            100                 105                 110


Asp His Ile Arg Ala Leu Asp Arg Leu Gln Glu Val Pro His Glu Gly 
        115                 120                 125


Pro Met Cys Asp Leu Leu Trp Ser Asp Pro Asp Asp Arg Gly Gly Trp 
    130                 135                 140


Gly Ile Ser Pro Arg Gly Ala Gly Tyr Thr Phe Gly Gln Asp Ile Ser 
145                 150                 155                 160


Glu Thr Phe Asn His Ala Asn Gly Leu Thr Leu Val Ser Arg Ala His 
                165                 170                 175


Gln Leu Val Met Glu Gly Tyr Asn Trp Cys His Asp Arg Asn Val Val 
            180                 185                 190


Thr Ile Phe Ser Ala Pro Asn Tyr Cys Tyr Arg Cys Gly Asn Gln Ala 
        195                 200                 205


Ala Ile Met Glu Leu Asp Asp Thr Leu Lys Tyr Ser Phe Leu Gln Phe 
    210                 215                 220


Asp Pro Ala Pro Arg Arg Gly Glu Pro His Val Thr Arg Arg Thr Pro 
225                 230                 235                 240


Asp Tyr Phe Leu 



<210>  2944
<211>  1663
<212>  DNA
<213>  Homo sapiens

<400>  2944
tttttttttt taaagtacta aaaaaaaaac aagttttgta attaggggga aaataaatac     60

atgtgtacct tacaggttgt ataaagtaca ggagattatt aagtcatcca gaaaaaaagc    120

attaacattt cttaagcccc tttggcaggg gtgggaatga gtagagattt ttttctctct    180

tgagtgaagt aacatttagt tgaattgagg gagtaaagta agatttttgt ctccttttcc    240

ttgcagggat ataactggtg ccatgaccgg aatgtagtaa cgattttcag tgctccaaac    300

tattgttatc gttgtggtaa ccaagctgca atcatggaac ttgacgatac tctaaaatac    360

tctttcttgc agtttgaccc agcacctcgt agaggcgagc cacatgttac tcgtcgtacc    420

ccagactact tcctgtaatg aaattttaaa cttgtacagt attgccatga accatatatc    480

gacctaatgg aaatgggaag agcaacagta actccaaagt gtcagaaaat agttaacatt    540

caaaaaactt gttttcacat ggaccaaaag atgtgccata taaaaataca aagcctcttg    600

tcatcaacag ccgtgaccac tttagaatga accagttcat tgcatgctga agcgacattg    660

ttggtcaaga aaccagtttc tggcatagcg ctatttgtag ttacttttgc tttctctgag    720

agactgcaga taataagatg taaacattaa cacctcgtga atacaattta acttccattt    780

agctatagct ttactcagca tgactgtaga taaggatagc agcaaacaat cattggagct    840

taatgaacat ttttaaaaat aattaccaag gcctcccttc tacttgtgag ttttgaaatt    900

gttcttttta ttttcaggga taccgtttaa tttaattata tgatttgtct gcactcagtt    960

tattccctac tcaaatctca gccccatgtt gttctttgtt attgtcagaa cctggtgagt   1020

tgttttgaac agaactgttt tttccccttc ctgtaagacg atgtgactgc acaagagcac   1080

tgcagtgttt ttcataataa acttgtgaac taagaactga gaaggtcaaa ttttaattgt   1140

atcaatgggc aagactggtg ctgtttatta aaaaagttaa atcaattgag taaattttag   1200

aatttgtaga cttgtaggta aaataaaaat caagggcact acataacctc tctggtaact   1260

ccttgacatt cttcagatta acttcaggat ttatttgtat ttcacatatt acaatttgtc   1320

acattgttgg tgtgcacttt gtgggttctt cctgcatatt aacttgtttg taagaaagga   1380

aatctgtgct gcttcagtaa gacttaattg taaaaccata taacttgaga tttaagtctt   1440

tgggttttgt tttaataaaa cagcatgttt tcaggtagag cttaaactaa atgatgtgtt   1500

tacttagtgc agtttctggt tatgaatatt atattgctat gtgtatatta tatggactct   1560

ttaaaatgat tgacagattg gcaaattctt aaatctttgt acattgttga gtcatatgtt   1620

cttagagtta aatttgtctc agataagaaa gtgttaaagc att                     1663


<210>  2945
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  2945

Met Glu Leu Asp Asp Thr Leu Lys Tyr Ser Phe Leu Gln Phe Asp Pro 
1               5                   10                  15


Ala Pro Arg Arg Gly Glu Pro His Val Thr Arg Arg Thr Pro Asp Tyr 
            20                  25                  30


Phe Leu 



<210>  2946
<211>  2939
<212>  DNA
<213>  Homo sapiens

<400>  2946
agaggtgggg gtggttaatc caagcggcca ctcgctgccc gttcctgccc ccaaagatga     60

cggaaaccca cacgattaca gagccgcagc accccagatg agccacgggg tcgcaattct    120

cgtttccgtg atcggactgc caggccccag gtgaggagct gagttcatca ccagagcggc    180

cttcccaggg gaaccagtta caggctgcca gtggccccgg cttccatccg gtctgcgcct    240

gcgcgcggcc caagccctcg cctctcctgg aatagtgctc agggattagt ccggttcgcc    300

gctgtgcgca ctgcgcatgc tccagctcca tccttccctt cccccaccac cccgccctcc    360

gggagccacg cccaaaaagt caaggcgctt cagttaccag ccggctacgt cgcgcctgcg    420

ctttgacccc cagtttgcgc cccaactccg gtcgtgcggc cgcccgggga gggctctgca    480

gttgcgcagc ttgctccccg gcccttttcc cctccgctcc ccgccgcctc ctgacgccgg    540

gcgtgacgtc accacgcccg gcggccgcca ttacagagag ccgagctctg gagcctcagc    600

gagcggagga ggaggcgcag cggccgacgg ccgagtactg cggtgagagc cagcgggcca    660

gcgccagcct caacagccgc cagaagtaca cgaggaaccg gcggcggcgt gtgcgtgtag    720

gcccgtgtgc gggcggcggc gcgggagcag cgcggagcgg cagccggctg gggcgggtgg    780

catcatggac gagaaggtgt tcaccaagga gctggaccag tggatcgagc agctgaacga    840

gtgcaagcag ctgtccgagt cccaggtcaa gagcctctgc gagaaggcta aagaaatcct    900

gacaaaagaa tccaacgtgc aagaggttcg atgtccagtt actgtctgtg gagatgtgca    960

tgggcaattt catgatctca tggaactgtt tagaattggt ggcaaatcac cagatacaaa   1020

ttacttgttt atgggagatt atgttgacag aggatattat tcagttgaaa cagttacact   1080

gcttgtagct cttaaggttc gttaccgtga acgcatcacc attcttcgag ggaatcatga   1140

gagcagacag atcacacaag tttatggttt ctatgatgaa tgtttaagaa aatatggaaa   1200

tgcaaatgtt tggaaatatt ttacagatct ttttgactat cttcctctca ctgccttggt   1260

ggatgggcag atcttctgtc tacatggtgg tctctcgcca tctatagata cactggatca   1320

tatcagagca cttgatcgcc tacaagaagt tccccatgag ggtccaatgt gtgacttgct   1380

gtggtcagat ccagatgacc gtggtggttg gggtatatct cctcgaggag ctggttacac   1440

ctttgggcaa gatatttctg agacatttaa tcatgccaat ggcctcacgt tggtgtctag   1500

agctcaccag ctagtgatgg agggatataa ctggtgccat gaccggaatg tagtaacgat   1560

tttcagtgct ccaaactatt gttatcgttg tggtaaccaa gctgcaatca tggaacttga   1620

cgatactcta aaatactctt tcttgcagtt tgacccagca cctcgtagag gcgagccaca   1680

tgttactcgt cgtaccccag actacttcct gtaatgaaat tttaaacttg tacagtattg   1740

ccatgaacca tatatcgacc taatggaaat gggaagagca acagtaactc caaagtgtca   1800

gaaaatagtt aacattcaaa aaacttgttt tcacatggac caaaagatgt gccatataaa   1860

aatacaaagc ctcttgtcat caacagccgt gaccacttta gaatgaacca gttcattgca   1920

tgctgaagcg acattgttgg tcaagaaacc agtttctggc atagcgctat ttgtagttac   1980

ttttgctttc tctgagagac tgcagataat aagatgtaaa cattaacacc tcgtgaatac   2040

aatttaactt ccatttagct atagctttac tcagcatgac tgtagataag gatagcagca   2100

aacaatcatt ggagcttaat gaacattttt aaaaataatt accaaggcct cccttctact   2160

tgtgagtttt gaaattgttc tttttatttt cagggatacc gtttaattta attatatgat   2220

ttgtctgcac tcagtttatt ccctactcaa atctcagccc catgttgttc tttgttattg   2280

tcagaacctg gtgagttgtt ttgaacagaa ctgttttttc cccttcctgt aagacgatgt   2340

gactgcacaa gagcactgca gtgtttttca taataaactt gtgaactaag aactgagaag   2400

gtcaaatttt aattgtatca atgggcaaga ctggtgctgt ttattaaaaa agttaaatca   2460

attgagtaaa ttttagaatt tgtagacttg taggtaaaat aaaaatcaag ggcactacat   2520

aacctctctg gtaactcctt gacattcttc agattaactt caggatttat ttgtatttca   2580

catattacaa tttgtcacat tgttggtgtg cactttgtgg gttcttcctg catattaact   2640

tgtttgtaag aaaggaaatc tgtgctgctt cagtaagact taattgtaaa accatataac   2700

ttgagattta agtctttggg ttttgtttta ataaaacagc atgttttcag gtagagctta   2760

aactaaatga tgtgtttact tagtgcagtt tctggttatg aatattatat tgctatgtgt   2820

atattatatg gactctttaa aatgattgac agattggcaa attcttaaat ctttgtacat   2880

tgttgagtca tatgttctta gagttaaatt tgtctcagat aagaaagtgt taaagcatt    2939


<210>  2947
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  2947

Met Asp Glu Lys Val Phe Thr Lys Glu Leu Asp Gln Trp Ile Glu Gln 
1               5                   10                  15


Leu Asn Glu Cys Lys Gln Leu Ser Glu Ser Gln Val Lys Ser Leu Cys 
            20                  25                  30


Glu Lys Ala Lys Glu Ile Leu Thr Lys Glu Ser Asn Val Gln Glu Val 
        35                  40                  45


Arg Cys Pro Val Thr Val Cys Gly Asp Val His Gly Gln Phe His Asp 
    50                  55                  60


Leu Met Glu Leu Phe Arg Ile Gly Gly Lys Ser Pro Asp Thr Asn Tyr 
65                  70                  75                  80


Leu Phe Met Gly Asp Tyr Val Asp Arg Gly Tyr Tyr Ser Val Glu Thr 
                85                  90                  95


Val Thr Leu Leu Val Ala Leu Lys Val Arg Tyr Arg Glu Arg Ile Thr 
            100                 105                 110


Ile Leu Arg Gly Asn His Glu Ser Arg Gln Ile Thr Gln Val Tyr Gly 
        115                 120                 125


Phe Tyr Asp Glu Cys Leu Arg Lys Tyr Gly Asn Ala Asn Val Trp Lys 
    130                 135                 140


Tyr Phe Thr Asp Leu Phe Asp Tyr Leu Pro Leu Thr Ala Leu Val Asp 
145                 150                 155                 160


Gly Gln Ile Phe Cys Leu His Gly Gly Leu Ser Pro Ser Ile Asp Thr 
                165                 170                 175


Leu Asp His Ile Arg Ala Leu Asp Arg Leu Gln Glu Val Pro His Glu 
            180                 185                 190


Gly Pro Met Cys Asp Leu Leu Trp Ser Asp Pro Asp Asp Arg Gly Gly 
        195                 200                 205


Trp Gly Ile Ser Pro Arg Gly Ala Gly Tyr Thr Phe Gly Gln Asp Ile 
    210                 215                 220


Ser Glu Thr Phe Asn His Ala Asn Gly Leu Thr Leu Val Ser Arg Ala 
225                 230                 235                 240


His Gln Leu Val Met Glu Gly Tyr Asn Trp Cys His Asp Arg Asn Val 
                245                 250                 255


Val Thr Ile Phe Ser Ala Pro Asn Tyr Cys Tyr Arg Cys Gly Asn Gln 
            260                 265                 270


Ala Ala Ile Met Glu Leu Asp Asp Thr Leu Lys Tyr Ser Phe Leu Gln 
        275                 280                 285


Phe Asp Pro Ala Pro Arg Arg Gly Glu Pro His Val Thr Arg Arg Thr 
    290                 295                 300


Pro Asp Tyr Phe Leu 
305


<210>  2948
<211>  2859
<212>  DNA
<213>  Homo sapiens

<400>  2948
agaggtgggg gtggttaatc caagcggcca ctcgctgccc gttcctgccc ccaaagatga     60

cggaaaccca cacgattaca gagccgcagc accccagatg agccacgggg tcgcaattct    120

cgtttccgtg atcggactgc caggccccag gtgaggagct gagttcatca ccagagcggc    180

cttcccaggg gaaccagtta caggctgcca gtggccccgg cttccatccg gtctgcgcct    240

gcgcgcggcc caagccctcg cctctcctgg aatagtgctc agggattagt ccggttcgcc    300

gctgtgcgca ctgcgcatgc tccagctcca tccttccctt cccccaccac cccgccctcc    360

gggagccacg cccaaaaagt caaggcgctt cagttaccag ccggctacgt cgcgcctgcg    420

ctttgacccc cagtttgcgc cccaactccg gtcgtgcggc cgcccgggga gggctctgca    480

gttgcgcagc ttgctccccg gcccttttcc cctccgctcc ccgccgcctc ctgacgccgg    540

gcgtgacgtc accacgcccg gcggccgcca ttacagagag ccgagctctg gagcctcagc    600

gagcggagga ggaggcgcag cggccgacgg ccgagtactg cggtgagagc cagcgggcca    660

gcgccagcct caacagccgc cagaagtaca cgaggaaccg gcggcggcgt gtgcgtgtag    720

gcccgtgtgc gggcggcggc gcgggagcag cgcggagcgg cagccggctg gggcgggtgg    780

catcatggac gagaaggtgt tcaccaagga gctggaccag tggatcgagc agctgaacga    840

gtgcaagcag ctgtccgatt actgtctgtg gagatgtgca tgggcaattt catgatctca    900

tggaactgtt tagaattggt ggcaaatcac cagatacaaa ttacttgttt atgggagatt    960

atgttgacag aggatattat tcagttgaaa cagttacact gcttgtagct cttaaggttc   1020

gttaccgtga acgcatcacc attcttcgag ggaatcatga gagcagacag atcacacaag   1080

tttatggttt ctatgatgaa tgtttaagaa aatatggaaa tgcaaatgtt tggaaatatt   1140

ttacagatct ttttgactat cttcctctca ctgccttggt ggatgggcag atcttctgtc   1200

tacatggtgg tctctcgcca tctatagata cactggatca tatcagagca cttgatcgcc   1260

tacaagaagt tccccatgag ggtccaatgt gtgacttgct gtggtcagat ccagatgacc   1320

gtggtggttg gggtatatct cctcgaggag ctggttacac ctttgggcaa gatatttctg   1380

agacatttaa tcatgccaat ggcctcacgt tggtgtctag agctcaccag ctagtgatgg   1440

agggatataa ctggtgccat gaccggaatg tagtaacgat tttcagtgct ccaaactatt   1500

gttatcgttg tggtaaccaa gctgcaatca tggaacttga cgatactcta aaatactctt   1560

tcttgcagtt tgacccagca cctcgtagag gcgagccaca tgttactcgt cgtaccccag   1620

actacttcct gtaatgaaat tttaaacttg tacagtattg ccatgaacca tatatcgacc   1680

taatggaaat gggaagagca acagtaactc caaagtgtca gaaaatagtt aacattcaaa   1740

aaacttgttt tcacatggac caaaagatgt gccatataaa aatacaaagc ctcttgtcat   1800

caacagccgt gaccacttta gaatgaacca gttcattgca tgctgaagcg acattgttgg   1860

tcaagaaacc agtttctggc atagcgctat ttgtagttac ttttgctttc tctgagagac   1920

tgcagataat aagatgtaaa cattaacacc tcgtgaatac aatttaactt ccatttagct   1980

atagctttac tcagcatgac tgtagataag gatagcagca aacaatcatt ggagcttaat   2040

gaacattttt aaaaataatt accaaggcct cccttctact tgtgagtttt gaaattgttc   2100

tttttatttt cagggatacc gtttaattta attatatgat ttgtctgcac tcagtttatt   2160

ccctactcaa atctcagccc catgttgttc tttgttattg tcagaacctg gtgagttgtt   2220

ttgaacagaa ctgttttttc cccttcctgt aagacgatgt gactgcacaa gagcactgca   2280

gtgtttttca taataaactt gtgaactaag aactgagaag gtcaaatttt aattgtatca   2340

atgggcaaga ctggtgctgt ttattaaaaa agttaaatca attgagtaaa ttttagaatt   2400

tgtagacttg taggtaaaat aaaaatcaag ggcactacat aacctctctg gtaactcctt   2460

gacattcttc agattaactt caggatttat ttgtatttca catattacaa tttgtcacat   2520

tgttggtgtg cactttgtgg gttcttcctg catattaact tgtttgtaag aaaggaaatc   2580

tgtgctgctt cagtaagact taattgtaaa accatataac ttgagattta agtctttggg   2640

ttttgtttta ataaaacagc atgttttcag gtagagctta aactaaatga tgtgtttact   2700

tagtgcagtt tctggttatg aatattatat tgctatgtgt atattatatg gactctttaa   2760

aatgattgac agattggcaa attcttaaat ctttgtacat tgttgagtca tatgttctta   2820

gagttaaatt tgtctcagat aagaaagtgt taaagcatt                          2859


<210>  2949
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  2949

Met Glu Leu Phe Arg Ile Gly Gly Lys Ser Pro Asp Thr Asn Tyr Leu 
1               5                   10                  15


Phe Met Gly Asp Tyr Val Asp Arg Gly Tyr Tyr Ser Val Glu Thr Val 
            20                  25                  30


Thr Leu Leu Val Ala Leu Lys Val Arg Tyr Arg Glu Arg Ile Thr Ile 
        35                  40                  45


Leu Arg Gly Asn His Glu Ser Arg Gln Ile Thr Gln Val Tyr Gly Phe 
    50                  55                  60


Tyr Asp Glu Cys Leu Arg Lys Tyr Gly Asn Ala Asn Val Trp Lys Tyr 
65                  70                  75                  80


Phe Thr Asp Leu Phe Asp Tyr Leu Pro Leu Thr Ala Leu Val Asp Gly 
                85                  90                  95


Gln Ile Phe Cys Leu His Gly Gly Leu Ser Pro Ser Ile Asp Thr Leu 
            100                 105                 110


Asp His Ile Arg Ala Leu Asp Arg Leu Gln Glu Val Pro His Glu Gly 
        115                 120                 125


Pro Met Cys Asp Leu Leu Trp Ser Asp Pro Asp Asp Arg Gly Gly Trp 
    130                 135                 140


Gly Ile Ser Pro Arg Gly Ala Gly Tyr Thr Phe Gly Gln Asp Ile Ser 
145                 150                 155                 160


Glu Thr Phe Asn His Ala Asn Gly Leu Thr Leu Val Ser Arg Ala His 
                165                 170                 175


Gln Leu Val Met Glu Gly Tyr Asn Trp Cys His Asp Arg Asn Val Val 
            180                 185                 190


Thr Ile Phe Ser Ala Pro Asn Tyr Cys Tyr Arg Cys Gly Asn Gln Ala 
        195                 200                 205


Ala Ile Met Glu Leu Asp Asp Thr Leu Lys Tyr Ser Phe Leu Gln Phe 
    210                 215                 220


Asp Pro Ala Pro Arg Arg Gly Glu Pro His Val Thr Arg Arg Thr Pro 
225                 230                 235                 240


Asp Tyr Phe Leu 



<210>  2950
<211>  1483
<212>  DNA
<213>  Homo sapiens

<400>  2950
tttttttttt taaagtacta aaaaaaaaac aagttttgta attaggggga aaataaatac     60

atgtgtacct tacaggttgt ataaagtaca ggagattatt aagtcatcca gaaaaaaagc    120

attaacattt cttaagcccc tttggcaggg gtgggaatga gtagagattt ttttctctct    180

tgagtgaagt aacatttagt tgaattgagg gagtaaagta agatttttgt ctccttttcc    240

ttgcagggat ataactggtg ccatgaccgg aatgtagtaa cgattttcag tgctccaaac    300

tattgttatc gttgtggtaa ccaagctgca atcatggaac ttgacgatac tctaaaatac    360

tctttcttgc agtttgaccc agcacctcgt agaggcgagc cacatgttac tcgtcgtacc    420

ccagactact tcctgtaatg aaattttaaa cttgtacagt attgccatga accatatatc    480

gacctaatgg aaatgggaag agcaacagta actccaaagt gtcagaaaat agttaacatt    540

caaaaaactt gttttcacat ggaccaaaag atgtgccata taaaaataca aagcctcttg    600

tcatcaacag ccgtgaccac tttagaatga accagttcat tgcatgctga agcgacattg    660

ttggtcaaga aaccagtttc tggcatagcg ctatttgtag ttacttttgc tttctctgag    720

agactgcaga taataagatg taaacattaa cacctcgtga atacaattta acttccattt    780

agctatagct ttactcagca tgactgtaga taaggatagc agcaaacaat cattggagct    840

taatgaacat ttttaaaaat aattaccaag gcctcccttc tacttgtgag ttttgaaatt    900

gttcttttta ttttcaggga taccgtttaa tttaattata tgatttgtct gcactcagtt    960

tattccctac tcaaatctca gccccatgtt gttctttgtt attgtcagaa cctggtgagt   1020

tgttttgaac agaactgttt tttccccttc ctgtaagacg atgtgactgc acaagagcac   1080

tgcagtgttt ttcataataa acttgtgaac taagaactga gaaggtcaaa ttttaattgt   1140

atcaatgggc aagactggtg ctgtttatta aaaaagttaa atcaattgag taaattttag   1200

aatttgtaga cttgtaggta aaataaaaat caagggcact acataacctc tctggtaact   1260

ccttgacatt cttcagatta acttcaggat ttatttgtat ttcacatatt acaatttgtc   1320

acattgttgg tgtgcacttt gtgggttctt cctgcatatt aacttgtttg taagaaagga   1380

aatctgtgct gcttcagtaa gacttaattg taaaaccata taacttgaga tttaagtctt   1440

tgggttttgt tttaataaaa cagcatgttt tcaggtagag ctt                     1483


<210>  2951
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  2951

Met Glu Leu Asp Asp Thr Leu Lys Tyr Ser Phe Leu Gln Phe Asp Pro 
1               5                   10                  15


Ala Pro Arg Arg Gly Glu Pro His Val Thr Arg Arg Thr Pro Asp Tyr 
            20                  25                  30


Phe Leu 



<210>  2952
<211>  2759
<212>  DNA
<213>  Homo sapiens

<400>  2952
agaggtgggg gtggttaatc caagcggcca ctcgctgccc gttcctgccc ccaaagatga     60

cggaaaccca cacgattaca gagccgcagc accccagatg agccacgggg tcgcaattct    120

cgtttccgtg atcggactgc caggccccag gtgaggagct gagttcatca ccagagcggc    180

cttcccaggg gaaccagtta caggctgcca gtggccccgg cttccatccg gtctgcgcct    240

gcgcgcggcc caagccctcg cctctcctgg aatagtgctc agggattagt ccggttcgcc    300

gctgtgcgca ctgcgcatgc tccagctcca tccttccctt cccccaccac cccgccctcc    360

gggagccacg cccaaaaagt caaggcgctt cagttaccag ccggctacgt cgcgcctgcg    420

ctttgacccc cagtttgcgc cccaactccg gtcgtgcggc cgcccgggga gggctctgca    480

gttgcgcagc ttgctccccg gcccttttcc cctccgctcc ccgccgcctc ctgacgccgg    540

gcgtgacgtc accacgcccg gcggccgcca ttacagagag ccgagctctg gagcctcagc    600

gagcggagga ggaggcgcag cggccgacgg ccgagtactg cggtgagagc cagcgggcca    660

gcgccagcct caacagccgc cagaagtaca cgaggaaccg gcggcggcgt gtgcgtgtag    720

gcccgtgtgc gggcggcggc gcgggagcag cgcggagcgg cagccggctg gggcgggtgg    780

catcatggac gagaaggtgt tcaccaagga gctggaccag tggatcgagc agctgaacga    840

gtgcaagcag ctgtccgagt cccaggtcaa gagcctctgc gagaaggcta aagaaatcct    900

gacaaaagaa tccaacgtgc aagaggttcg atgtccagtt actgtctgtg gagatgtgca    960

tgggcaattt catgatctca tggaactgtt tagaattggt ggcaaatcac cagatacaaa   1020

ttacttgttt atgggagatt atgttgacag aggatattat tcagttgaaa cagttacact   1080

gcttgtagct cttaaggttc gttaccgtga acgcatcacc attcttcgag ggaatcatga   1140

gagcagacag atcacacaag tttatggttt ctatgatgaa tgtttaagaa aatatggaaa   1200

tgcaaatgtt tggaaatatt ttacagatct ttttgactat cttcctctca ctgccttggt   1260

ggatgggcag atcttctgtc tacatggtgg tctctcgcca tctatagata cactggatca   1320

tatcagagca cttgatcgcc tacaagaagt tccccatgag ggtccaatgt gtgacttgct   1380

gtggtcagat ccagatgacc gtggtggttg gggtatatct cctcgaggag ctggttacac   1440

ctttgggcaa gatatttctg agacatttaa tcatgccaat ggcctcacgt tggtgtctag   1500

agctcaccag ctagtgatgg agggatataa ctggtgccat gaccggaatg tagtaacgat   1560

tttcagtgct ccaaactatt gttatcgttg tggtaaccaa gctgcaatca tggaacttga   1620

cgatactcta aaatactctt tcttgcagtt tgacccagca cctcgtagag gcgagccaca   1680

tgttactcgt cgtaccccag actacttcct gtaatgaaat tttaaacttg tacagtattg   1740

ccatgaacca tatatcgacc taatggaaat gggaagagca acagtaactc caaagtgtca   1800

gaaaatagtt aacattcaaa aaacttgttt tcacatggac caaaagatgt gccatataaa   1860

aatacaaagc ctcttgtcat caacagccgt gaccacttta gaatgaacca gttcattgca   1920

tgctgaagcg acattgttgg tcaagaaacc agtttctggc atagcgctat ttgtagttac   1980

ttttgctttc tctgagagac tgcagataat aagatgtaaa cattaacacc tcgtgaatac   2040

aatttaactt ccatttagct atagctttac tcagcatgac tgtagataag gatagcagca   2100

aacaatcatt ggagcttaat gaacattttt aaaaataatt accaaggcct cccttctact   2160

tgtgagtttt gaaattgttc tttttatttt cagggatacc gtttaattta attatatgat   2220

ttgtctgcac tcagtttatt ccctactcaa atctcagccc catgttgttc tttgttattg   2280

tcagaacctg gtgagttgtt ttgaacagaa ctgttttttc cccttcctgt aagacgatgt   2340

gactgcacaa gagcactgca gtgtttttca taataaactt gtgaactaag aactgagaag   2400

gtcaaatttt aattgtatca atgggcaaga ctggtgctgt ttattaaaaa agttaaatca   2460

attgagtaaa ttttagaatt tgtagacttg taggtaaaat aaaaatcaag ggcactacat   2520

aacctctctg gtaactcctt gacattcttc agattaactt caggatttat ttgtatttca   2580

catattacaa tttgtcacat tgttggtgtg cactttgtgg gttcttcctg catattaact   2640

tgtttgtaag aaaggaaatc tgtgctgctt cagtaagact taattgtaaa accatataac   2700

ttgagattta agtctttggg ttttgtttta ataaaacagc atgttttcag gtagagctt    2759


<210>  2953
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  2953

Met Asp Glu Lys Val Phe Thr Lys Glu Leu Asp Gln Trp Ile Glu Gln 
1               5                   10                  15


Leu Asn Glu Cys Lys Gln Leu Ser Glu Ser Gln Val Lys Ser Leu Cys 
            20                  25                  30


Glu Lys Ala Lys Glu Ile Leu Thr Lys Glu Ser Asn Val Gln Glu Val 
        35                  40                  45


Arg Cys Pro Val Thr Val Cys Gly Asp Val His Gly Gln Phe His Asp 
    50                  55                  60


Leu Met Glu Leu Phe Arg Ile Gly Gly Lys Ser Pro Asp Thr Asn Tyr 
65                  70                  75                  80


Leu Phe Met Gly Asp Tyr Val Asp Arg Gly Tyr Tyr Ser Val Glu Thr 
                85                  90                  95


Val Thr Leu Leu Val Ala Leu Lys Val Arg Tyr Arg Glu Arg Ile Thr 
            100                 105                 110


Ile Leu Arg Gly Asn His Glu Ser Arg Gln Ile Thr Gln Val Tyr Gly 
        115                 120                 125


Phe Tyr Asp Glu Cys Leu Arg Lys Tyr Gly Asn Ala Asn Val Trp Lys 
    130                 135                 140


Tyr Phe Thr Asp Leu Phe Asp Tyr Leu Pro Leu Thr Ala Leu Val Asp 
145                 150                 155                 160


Gly Gln Ile Phe Cys Leu His Gly Gly Leu Ser Pro Ser Ile Asp Thr 
                165                 170                 175


Leu Asp His Ile Arg Ala Leu Asp Arg Leu Gln Glu Val Pro His Glu 
            180                 185                 190


Gly Pro Met Cys Asp Leu Leu Trp Ser Asp Pro Asp Asp Arg Gly Gly 
        195                 200                 205


Trp Gly Ile Ser Pro Arg Gly Ala Gly Tyr Thr Phe Gly Gln Asp Ile 
    210                 215                 220


Ser Glu Thr Phe Asn His Ala Asn Gly Leu Thr Leu Val Ser Arg Ala 
225                 230                 235                 240


His Gln Leu Val Met Glu Gly Tyr Asn Trp Cys His Asp Arg Asn Val 
                245                 250                 255


Val Thr Ile Phe Ser Ala Pro Asn Tyr Cys Tyr Arg Cys Gly Asn Gln 
            260                 265                 270


Ala Ala Ile Met Glu Leu Asp Asp Thr Leu Lys Tyr Ser Phe Leu Gln 
        275                 280                 285


Phe Asp Pro Ala Pro Arg Arg Gly Glu Pro His Val Thr Arg Arg Thr 
    290                 295                 300


Pro Asp Tyr Phe Leu 
305


<210>  2954
<211>  2679
<212>  DNA
<213>  Homo sapiens

<400>  2954
agaggtgggg gtggttaatc caagcggcca ctcgctgccc gttcctgccc ccaaagatga     60

cggaaaccca cacgattaca gagccgcagc accccagatg agccacgggg tcgcaattct    120

cgtttccgtg atcggactgc caggccccag gtgaggagct gagttcatca ccagagcggc    180

cttcccaggg gaaccagtta caggctgcca gtggccccgg cttccatccg gtctgcgcct    240

gcgcgcggcc caagccctcg cctctcctgg aatagtgctc agggattagt ccggttcgcc    300

gctgtgcgca ctgcgcatgc tccagctcca tccttccctt cccccaccac cccgccctcc    360

gggagccacg cccaaaaagt caaggcgctt cagttaccag ccggctacgt cgcgcctgcg    420

ctttgacccc cagtttgcgc cccaactccg gtcgtgcggc cgcccgggga gggctctgca    480

gttgcgcagc ttgctccccg gcccttttcc cctccgctcc ccgccgcctc ctgacgccgg    540

gcgtgacgtc accacgcccg gcggccgcca ttacagagag ccgagctctg gagcctcagc    600

gagcggagga ggaggcgcag cggccgacgg ccgagtactg cggtgagagc cagcgggcca    660

gcgccagcct caacagccgc cagaagtaca cgaggaaccg gcggcggcgt gtgcgtgtag    720

gcccgtgtgc gggcggcggc gcgggagcag cgcggagcgg cagccggctg gggcgggtgg    780

catcatggac gagaaggtgt tcaccaagga gctggaccag tggatcgagc agctgaacga    840

gtgcaagcag ctgtccgatt actgtctgtg gagatgtgca tgggcaattt catgatctca    900

tggaactgtt tagaattggt ggcaaatcac cagatacaaa ttacttgttt atgggagatt    960

atgttgacag aggatattat tcagttgaaa cagttacact gcttgtagct cttaaggttc   1020

gttaccgtga acgcatcacc attcttcgag ggaatcatga gagcagacag atcacacaag   1080

tttatggttt ctatgatgaa tgtttaagaa aatatggaaa tgcaaatgtt tggaaatatt   1140

ttacagatct ttttgactat cttcctctca ctgccttggt ggatgggcag atcttctgtc   1200

tacatggtgg tctctcgcca tctatagata cactggatca tatcagagca cttgatcgcc   1260

tacaagaagt tccccatgag ggtccaatgt gtgacttgct gtggtcagat ccagatgacc   1320

gtggtggttg gggtatatct cctcgaggag ctggttacac ctttgggcaa gatatttctg   1380

agacatttaa tcatgccaat ggcctcacgt tggtgtctag agctcaccag ctagtgatgg   1440

agggatataa ctggtgccat gaccggaatg tagtaacgat tttcagtgct ccaaactatt   1500

gttatcgttg tggtaaccaa gctgcaatca tggaacttga cgatactcta aaatactctt   1560

tcttgcagtt tgacccagca cctcgtagag gcgagccaca tgttactcgt cgtaccccag   1620

actacttcct gtaatgaaat tttaaacttg tacagtattg ccatgaacca tatatcgacc   1680

taatggaaat gggaagagca acagtaactc caaagtgtca gaaaatagtt aacattcaaa   1740

aaacttgttt tcacatggac caaaagatgt gccatataaa aatacaaagc ctcttgtcat   1800

caacagccgt gaccacttta gaatgaacca gttcattgca tgctgaagcg acattgttgg   1860

tcaagaaacc agtttctggc atagcgctat ttgtagttac ttttgctttc tctgagagac   1920

tgcagataat aagatgtaaa cattaacacc tcgtgaatac aatttaactt ccatttagct   1980

atagctttac tcagcatgac tgtagataag gatagcagca aacaatcatt ggagcttaat   2040

gaacattttt aaaaataatt accaaggcct cccttctact tgtgagtttt gaaattgttc   2100

tttttatttt cagggatacc gtttaattta attatatgat ttgtctgcac tcagtttatt   2160

ccctactcaa atctcagccc catgttgttc tttgttattg tcagaacctg gtgagttgtt   2220

ttgaacagaa ctgttttttc cccttcctgt aagacgatgt gactgcacaa gagcactgca   2280

gtgtttttca taataaactt gtgaactaag aactgagaag gtcaaatttt aattgtatca   2340

atgggcaaga ctggtgctgt ttattaaaaa agttaaatca attgagtaaa ttttagaatt   2400

tgtagacttg taggtaaaat aaaaatcaag ggcactacat aacctctctg gtaactcctt   2460

gacattcttc agattaactt caggatttat ttgtatttca catattacaa tttgtcacat   2520

tgttggtgtg cactttgtgg gttcttcctg catattaact tgtttgtaag aaaggaaatc   2580

tgtgctgctt cagtaagact taattgtaaa accatataac ttgagattta agtctttggg   2640

ttttgtttta ataaaacagc atgttttcag gtagagctt                          2679


<210>  2955
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  2955

Met Glu Leu Phe Arg Ile Gly Gly Lys Ser Pro Asp Thr Asn Tyr Leu 
1               5                   10                  15


Phe Met Gly Asp Tyr Val Asp Arg Gly Tyr Tyr Ser Val Glu Thr Val 
            20                  25                  30


Thr Leu Leu Val Ala Leu Lys Val Arg Tyr Arg Glu Arg Ile Thr Ile 
        35                  40                  45


Leu Arg Gly Asn His Glu Ser Arg Gln Ile Thr Gln Val Tyr Gly Phe 
    50                  55                  60


Tyr Asp Glu Cys Leu Arg Lys Tyr Gly Asn Ala Asn Val Trp Lys Tyr 
65                  70                  75                  80


Phe Thr Asp Leu Phe Asp Tyr Leu Pro Leu Thr Ala Leu Val Asp Gly 
                85                  90                  95


Gln Ile Phe Cys Leu His Gly Gly Leu Ser Pro Ser Ile Asp Thr Leu 
            100                 105                 110


Asp His Ile Arg Ala Leu Asp Arg Leu Gln Glu Val Pro His Glu Gly 
        115                 120                 125


Pro Met Cys Asp Leu Leu Trp Ser Asp Pro Asp Asp Arg Gly Gly Trp 
    130                 135                 140


Gly Ile Ser Pro Arg Gly Ala Gly Tyr Thr Phe Gly Gln Asp Ile Ser 
145                 150                 155                 160


Glu Thr Phe Asn His Ala Asn Gly Leu Thr Leu Val Ser Arg Ala His 
                165                 170                 175


Gln Leu Val Met Glu Gly Tyr Asn Trp Cys His Asp Arg Asn Val Val 
            180                 185                 190


Thr Ile Phe Ser Ala Pro Asn Tyr Cys Tyr Arg Cys Gly Asn Gln Ala 
        195                 200                 205


Ala Ile Met Glu Leu Asp Asp Thr Leu Lys Tyr Ser Phe Leu Gln Phe 
    210                 215                 220


Asp Pro Ala Pro Arg Arg Gly Glu Pro His Val Thr Arg Arg Thr Pro 
225                 230                 235                 240


Asp Tyr Phe Leu 



<210>  2956
<211>  1240
<212>  DNA
<213>  Homo sapiens

<400>  2956
tttttttttt taaagtacta aaaaaaaaac aagttttgta attaggggga aaataaatac     60

atgtgtacct tacaggttgt ataaagtaca ggagattatt aagtcatcca gaaaaaaagc    120

attaacattt cttaagcccc tttggcaggg gtgggaatga gtagagattt ttttctctct    180

tgagtgaagt aacatttagt tgaattgagg gagtaaagta agatttttgt ctccttttcc    240

ttgcagggat ataactggtg ccatgaccgg aatgtagtaa cgattttcag tgctccaaac    300

tattgttatc gttgtggtaa ccaagctgca atcatggaac ttgacgatac tctaaaatac    360

tctttcttgc agtttgaccc agcacctcgt agaggcgagc cacatgttac tcgtcgtacc    420

ccagactact tcctgtaatg aaattttaaa cttgtacagt attgccatga accatatatc    480

gacctaatgg aaatgggaag agcaacagta actccaaagt gtcagaaaat agttaacatt    540

caaaaaactt gttttcacat ggaccaaaag atgtgccata taaaaataca aagcctcttg    600

tcatcaacag ccgtgaccac tttagaatga accagttcat tgcatgctga agcgacattg    660

ttggtcaaga aaccagtttc tggcatagcg ctatttgtag ttacttttgc tttctctgag    720

agactgcaga taataagatg taaacattaa cacctcgtga atacaattta acttccattt    780

agctatagct ttactcagca tgactgtaga taaggatagc agcaaacaat cattggagct    840

taatgaacat ttttaaaaat aattaccaag gcctcccttc tacttgtgag ttttgaaatt    900

gttcttttta ttttcaggga taccgtttaa tttaattata tgatttgtct gcactcagtt    960

tattccctac tcaaatctca gccccatgtt gttctttgtt attgtcagaa cctggtgagt   1020

tgttttgaac agaactgttt tttccccttc ctgtaagacg atgtgactgc acaagagcac   1080

tgcagtgttt ttcataataa acttgtgaac taagaactga gaaggtcaaa ttttaattgt   1140

atcaatgggc aagactggtg ctgtttatta aaaaagttaa atcaattgag taaattttag   1200

aatttgtaga cttgtaggta aaataaaaat caagggcact                         1240


<210>  2957
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  2957

Met Glu Leu Asp Asp Thr Leu Lys Tyr Ser Phe Leu Gln Phe Asp Pro 
1               5                   10                  15


Ala Pro Arg Arg Gly Glu Pro His Val Thr Arg Arg Thr Pro Asp Tyr 
            20                  25                  30


Phe Leu 



<210>  2958
<211>  2516
<212>  DNA
<213>  Homo sapiens

<400>  2958
agaggtgggg gtggttaatc caagcggcca ctcgctgccc gttcctgccc ccaaagatga     60

cggaaaccca cacgattaca gagccgcagc accccagatg agccacgggg tcgcaattct    120

cgtttccgtg atcggactgc caggccccag gtgaggagct gagttcatca ccagagcggc    180

cttcccaggg gaaccagtta caggctgcca gtggccccgg cttccatccg gtctgcgcct    240

gcgcgcggcc caagccctcg cctctcctgg aatagtgctc agggattagt ccggttcgcc    300

gctgtgcgca ctgcgcatgc tccagctcca tccttccctt cccccaccac cccgccctcc    360

gggagccacg cccaaaaagt caaggcgctt cagttaccag ccggctacgt cgcgcctgcg    420

ctttgacccc cagtttgcgc cccaactccg gtcgtgcggc cgcccgggga gggctctgca    480

gttgcgcagc ttgctccccg gcccttttcc cctccgctcc ccgccgcctc ctgacgccgg    540

gcgtgacgtc accacgcccg gcggccgcca ttacagagag ccgagctctg gagcctcagc    600

gagcggagga ggaggcgcag cggccgacgg ccgagtactg cggtgagagc cagcgggcca    660

gcgccagcct caacagccgc cagaagtaca cgaggaaccg gcggcggcgt gtgcgtgtag    720

gcccgtgtgc gggcggcggc gcgggagcag cgcggagcgg cagccggctg gggcgggtgg    780

catcatggac gagaaggtgt tcaccaagga gctggaccag tggatcgagc agctgaacga    840

gtgcaagcag ctgtccgagt cccaggtcaa gagcctctgc gagaaggcta aagaaatcct    900

gacaaaagaa tccaacgtgc aagaggttcg atgtccagtt actgtctgtg gagatgtgca    960

tgggcaattt catgatctca tggaactgtt tagaattggt ggcaaatcac cagatacaaa   1020

ttacttgttt atgggagatt atgttgacag aggatattat tcagttgaaa cagttacact   1080

gcttgtagct cttaaggttc gttaccgtga acgcatcacc attcttcgag ggaatcatga   1140

gagcagacag atcacacaag tttatggttt ctatgatgaa tgtttaagaa aatatggaaa   1200

tgcaaatgtt tggaaatatt ttacagatct ttttgactat cttcctctca ctgccttggt   1260

ggatgggcag atcttctgtc tacatggtgg tctctcgcca tctatagata cactggatca   1320

tatcagagca cttgatcgcc tacaagaagt tccccatgag ggtccaatgt gtgacttgct   1380

gtggtcagat ccagatgacc gtggtggttg gggtatatct cctcgaggag ctggttacac   1440

ctttgggcaa gatatttctg agacatttaa tcatgccaat ggcctcacgt tggtgtctag   1500

agctcaccag ctagtgatgg agggatataa ctggtgccat gaccggaatg tagtaacgat   1560

tttcagtgct ccaaactatt gttatcgttg tggtaaccaa gctgcaatca tggaacttga   1620

cgatactcta aaatactctt tcttgcagtt tgacccagca cctcgtagag gcgagccaca   1680

tgttactcgt cgtaccccag actacttcct gtaatgaaat tttaaacttg tacagtattg   1740

ccatgaacca tatatcgacc taatggaaat gggaagagca acagtaactc caaagtgtca   1800

gaaaatagtt aacattcaaa aaacttgttt tcacatggac caaaagatgt gccatataaa   1860

aatacaaagc ctcttgtcat caacagccgt gaccacttta gaatgaacca gttcattgca   1920

tgctgaagcg acattgttgg tcaagaaacc agtttctggc atagcgctat ttgtagttac   1980

ttttgctttc tctgagagac tgcagataat aagatgtaaa cattaacacc tcgtgaatac   2040

aatttaactt ccatttagct atagctttac tcagcatgac tgtagataag gatagcagca   2100

aacaatcatt ggagcttaat gaacattttt aaaaataatt accaaggcct cccttctact   2160

tgtgagtttt gaaattgttc tttttatttt cagggatacc gtttaattta attatatgat   2220

ttgtctgcac tcagtttatt ccctactcaa atctcagccc catgttgttc tttgttattg   2280

tcagaacctg gtgagttgtt ttgaacagaa ctgttttttc cccttcctgt aagacgatgt   2340

gactgcacaa gagcactgca gtgtttttca taataaactt gtgaactaag aactgagaag   2400

gtcaaatttt aattgtatca atgggcaaga ctggtgctgt ttattaaaaa agttaaatca   2460

attgagtaaa ttttagaatt tgtagacttg taggtaaaat aaaaatcaag ggcact       2516


<210>  2959
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  2959

Met Asp Glu Lys Val Phe Thr Lys Glu Leu Asp Gln Trp Ile Glu Gln 
1               5                   10                  15


Leu Asn Glu Cys Lys Gln Leu Ser Glu Ser Gln Val Lys Ser Leu Cys 
            20                  25                  30


Glu Lys Ala Lys Glu Ile Leu Thr Lys Glu Ser Asn Val Gln Glu Val 
        35                  40                  45


Arg Cys Pro Val Thr Val Cys Gly Asp Val His Gly Gln Phe His Asp 
    50                  55                  60


Leu Met Glu Leu Phe Arg Ile Gly Gly Lys Ser Pro Asp Thr Asn Tyr 
65                  70                  75                  80


Leu Phe Met Gly Asp Tyr Val Asp Arg Gly Tyr Tyr Ser Val Glu Thr 
                85                  90                  95


Val Thr Leu Leu Val Ala Leu Lys Val Arg Tyr Arg Glu Arg Ile Thr 
            100                 105                 110


Ile Leu Arg Gly Asn His Glu Ser Arg Gln Ile Thr Gln Val Tyr Gly 
        115                 120                 125


Phe Tyr Asp Glu Cys Leu Arg Lys Tyr Gly Asn Ala Asn Val Trp Lys 
    130                 135                 140


Tyr Phe Thr Asp Leu Phe Asp Tyr Leu Pro Leu Thr Ala Leu Val Asp 
145                 150                 155                 160


Gly Gln Ile Phe Cys Leu His Gly Gly Leu Ser Pro Ser Ile Asp Thr 
                165                 170                 175


Leu Asp His Ile Arg Ala Leu Asp Arg Leu Gln Glu Val Pro His Glu 
            180                 185                 190


Gly Pro Met Cys Asp Leu Leu Trp Ser Asp Pro Asp Asp Arg Gly Gly 
        195                 200                 205


Trp Gly Ile Ser Pro Arg Gly Ala Gly Tyr Thr Phe Gly Gln Asp Ile 
    210                 215                 220


Ser Glu Thr Phe Asn His Ala Asn Gly Leu Thr Leu Val Ser Arg Ala 
225                 230                 235                 240


His Gln Leu Val Met Glu Gly Tyr Asn Trp Cys His Asp Arg Asn Val 
                245                 250                 255


Val Thr Ile Phe Ser Ala Pro Asn Tyr Cys Tyr Arg Cys Gly Asn Gln 
            260                 265                 270


Ala Ala Ile Met Glu Leu Asp Asp Thr Leu Lys Tyr Ser Phe Leu Gln 
        275                 280                 285


Phe Asp Pro Ala Pro Arg Arg Gly Glu Pro His Val Thr Arg Arg Thr 
    290                 295                 300


Pro Asp Tyr Phe Leu 
305


<210>  2960
<211>  2436
<212>  DNA
<213>  Homo sapiens

<400>  2960
agaggtgggg gtggttaatc caagcggcca ctcgctgccc gttcctgccc ccaaagatga     60

cggaaaccca cacgattaca gagccgcagc accccagatg agccacgggg tcgcaattct    120

cgtttccgtg atcggactgc caggccccag gtgaggagct gagttcatca ccagagcggc    180

cttcccaggg gaaccagtta caggctgcca gtggccccgg cttccatccg gtctgcgcct    240

gcgcgcggcc caagccctcg cctctcctgg aatagtgctc agggattagt ccggttcgcc    300

gctgtgcgca ctgcgcatgc tccagctcca tccttccctt cccccaccac cccgccctcc    360

gggagccacg cccaaaaagt caaggcgctt cagttaccag ccggctacgt cgcgcctgcg    420

ctttgacccc cagtttgcgc cccaactccg gtcgtgcggc cgcccgggga gggctctgca    480

gttgcgcagc ttgctccccg gcccttttcc cctccgctcc ccgccgcctc ctgacgccgg    540

gcgtgacgtc accacgcccg gcggccgcca ttacagagag ccgagctctg gagcctcagc    600

gagcggagga ggaggcgcag cggccgacgg ccgagtactg cggtgagagc cagcgggcca    660

gcgccagcct caacagccgc cagaagtaca cgaggaaccg gcggcggcgt gtgcgtgtag    720

gcccgtgtgc gggcggcggc gcgggagcag cgcggagcgg cagccggctg gggcgggtgg    780

catcatggac gagaaggtgt tcaccaagga gctggaccag tggatcgagc agctgaacga    840

gtgcaagcag ctgtccgatt actgtctgtg gagatgtgca tgggcaattt catgatctca    900

tggaactgtt tagaattggt ggcaaatcac cagatacaaa ttacttgttt atgggagatt    960

atgttgacag aggatattat tcagttgaaa cagttacact gcttgtagct cttaaggttc   1020

gttaccgtga acgcatcacc attcttcgag ggaatcatga gagcagacag atcacacaag   1080

tttatggttt ctatgatgaa tgtttaagaa aatatggaaa tgcaaatgtt tggaaatatt   1140

ttacagatct ttttgactat cttcctctca ctgccttggt ggatgggcag atcttctgtc   1200

tacatggtgg tctctcgcca tctatagata cactggatca tatcagagca cttgatcgcc   1260

tacaagaagt tccccatgag ggtccaatgt gtgacttgct gtggtcagat ccagatgacc   1320

gtggtggttg gggtatatct cctcgaggag ctggttacac ctttgggcaa gatatttctg   1380

agacatttaa tcatgccaat ggcctcacgt tggtgtctag agctcaccag ctagtgatgg   1440

agggatataa ctggtgccat gaccggaatg tagtaacgat tttcagtgct ccaaactatt   1500

gttatcgttg tggtaaccaa gctgcaatca tggaacttga cgatactcta aaatactctt   1560

tcttgcagtt tgacccagca cctcgtagag gcgagccaca tgttactcgt cgtaccccag   1620

actacttcct gtaatgaaat tttaaacttg tacagtattg ccatgaacca tatatcgacc   1680

taatggaaat gggaagagca acagtaactc caaagtgtca gaaaatagtt aacattcaaa   1740

aaacttgttt tcacatggac caaaagatgt gccatataaa aatacaaagc ctcttgtcat   1800

caacagccgt gaccacttta gaatgaacca gttcattgca tgctgaagcg acattgttgg   1860

tcaagaaacc agtttctggc atagcgctat ttgtagttac ttttgctttc tctgagagac   1920

tgcagataat aagatgtaaa cattaacacc tcgtgaatac aatttaactt ccatttagct   1980

atagctttac tcagcatgac tgtagataag gatagcagca aacaatcatt ggagcttaat   2040

gaacattttt aaaaataatt accaaggcct cccttctact tgtgagtttt gaaattgttc   2100

tttttatttt cagggatacc gtttaattta attatatgat ttgtctgcac tcagtttatt   2160

ccctactcaa atctcagccc catgttgttc tttgttattg tcagaacctg gtgagttgtt   2220

ttgaacagaa ctgttttttc cccttcctgt aagacgatgt gactgcacaa gagcactgca   2280

gtgtttttca taataaactt gtgaactaag aactgagaag gtcaaatttt aattgtatca   2340

atgggcaaga ctggtgctgt ttattaaaaa agttaaatca attgagtaaa ttttagaatt   2400

tgtagacttg taggtaaaat aaaaatcaag ggcact                             2436


<210>  2961
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  2961

Met Glu Leu Phe Arg Ile Gly Gly Lys Ser Pro Asp Thr Asn Tyr Leu 
1               5                   10                  15


Phe Met Gly Asp Tyr Val Asp Arg Gly Tyr Tyr Ser Val Glu Thr Val 
            20                  25                  30


Thr Leu Leu Val Ala Leu Lys Val Arg Tyr Arg Glu Arg Ile Thr Ile 
        35                  40                  45


Leu Arg Gly Asn His Glu Ser Arg Gln Ile Thr Gln Val Tyr Gly Phe 
    50                  55                  60


Tyr Asp Glu Cys Leu Arg Lys Tyr Gly Asn Ala Asn Val Trp Lys Tyr 
65                  70                  75                  80


Phe Thr Asp Leu Phe Asp Tyr Leu Pro Leu Thr Ala Leu Val Asp Gly 
                85                  90                  95


Gln Ile Phe Cys Leu His Gly Gly Leu Ser Pro Ser Ile Asp Thr Leu 
            100                 105                 110


Asp His Ile Arg Ala Leu Asp Arg Leu Gln Glu Val Pro His Glu Gly 
        115                 120                 125


Pro Met Cys Asp Leu Leu Trp Ser Asp Pro Asp Asp Arg Gly Gly Trp 
    130                 135                 140


Gly Ile Ser Pro Arg Gly Ala Gly Tyr Thr Phe Gly Gln Asp Ile Ser 
145                 150                 155                 160


Glu Thr Phe Asn His Ala Asn Gly Leu Thr Leu Val Ser Arg Ala His 
                165                 170                 175


Gln Leu Val Met Glu Gly Tyr Asn Trp Cys His Asp Arg Asn Val Val 
            180                 185                 190


Thr Ile Phe Ser Ala Pro Asn Tyr Cys Tyr Arg Cys Gly Asn Gln Ala 
        195                 200                 205


Ala Ile Met Glu Leu Asp Asp Thr Leu Lys Tyr Ser Phe Leu Gln Phe 
    210                 215                 220


Asp Pro Ala Pro Arg Arg Gly Glu Pro His Val Thr Arg Arg Thr Pro 
225                 230                 235                 240


Asp Tyr Phe Leu 



<210>  2962
<211>  1140
<212>  DNA
<213>  Homo sapiens

<400>  2962
tttttttttt taaagtacta aaaaaaaaac aagttttgta attaggggga aaataaatac     60

atgtgtacct tacaggttgt ataaagtaca ggagattatt aagtcatcca gaaaaaaagc    120

attaacattt cttaagcccc tttggcaggg gtgggaatga gtagagattt ttttctctct    180

tgagtgaagt aacatttagt tgaattgagg gagtaaagta agatttttgt ctccttttcc    240

ttgcagggat ataactggtg ccatgaccgg aatgtagtaa cgattttcag tgctccaaac    300

tattgttatc gttgtggtaa ccaagctgca atcatggaac ttgacgatac tctaaaatac    360

tctttcttgc agtttgaccc agcacctcgt agaggcgagc cacatgttac tcgtcgtacc    420

ccagactact tcctgtaatg aaattttaaa cttgtacagt attgccatga accatatatc    480

gacctaatgg aaatgggaag agcaacagta actccaaagt gtcagaaaat agttaacatt    540

caaaaaactt gttttcacat ggaccaaaag atgtgccata taaaaataca aagcctcttg    600

tcatcaacag ccgtgaccac tttagaatga accagttcat tgcatgctga agcgacattg    660

ttggtcaaga aaccagtttc tggcatagcg ctatttgtag ttacttttgc tttctctgag    720

agactgcaga taataagatg taaacattaa cacctcgtga atacaattta acttccattt    780

agctatagct ttactcagca tgactgtaga taaggatagc agcaaacaat cattggagct    840

taatgaacat ttttaaaaat aattaccaag gcctcccttc tacttgtgag ttttgaaatt    900

gttcttttta ttttcaggga taccgtttaa tttaattata tgatttgtct gcactcagtt    960

tattccctac tcaaatctca gccccatgtt gttctttgtt attgtcagaa cctggtgagt   1020

tgttttgaac agaactgttt tttccccttc ctgtaagacg atgtgactgc acaagagcac   1080

tgcagtgttt ttcataataa acttgtgaac taagaactga gaaggtcaaa ttttaattgt   1140


<210>  2963
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  2963

Met Glu Leu Asp Asp Thr Leu Lys Tyr Ser Phe Leu Gln Phe Asp Pro 
1               5                   10                  15


Ala Pro Arg Arg Gly Glu Pro His Val Thr Arg Arg Thr Pro Asp Tyr 
            20                  25                  30


Phe Leu 



<210>  2964
<211>  2336
<212>  DNA
<213>  Homo sapiens

<400>  2964
agaggtgggg gtggttaatc caagcggcca ctcgctgccc gttcctgccc ccaaagatga     60

cggaaaccca cacgattaca gagccgcagc accccagatg agccacgggg tcgcaattct    120

cgtttccgtg atcggactgc caggccccag gtgaggagct gagttcatca ccagagcggc    180

cttcccaggg gaaccagtta caggctgcca gtggccccgg cttccatccg gtctgcgcct    240

gcgcgcggcc caagccctcg cctctcctgg aatagtgctc agggattagt ccggttcgcc    300

gctgtgcgca ctgcgcatgc tccagctcca tccttccctt cccccaccac cccgccctcc    360

gggagccacg cccaaaaagt caaggcgctt cagttaccag ccggctacgt cgcgcctgcg    420

ctttgacccc cagtttgcgc cccaactccg gtcgtgcggc cgcccgggga gggctctgca    480

gttgcgcagc ttgctccccg gcccttttcc cctccgctcc ccgccgcctc ctgacgccgg    540

gcgtgacgtc accacgcccg gcggccgcca ttacagagag ccgagctctg gagcctcagc    600

gagcggagga ggaggcgcag cggccgacgg ccgagtactg cggtgagagc cagcgggcca    660

gcgccagcct caacagccgc cagaagtaca cgaggaaccg gcggcggcgt gtgcgtgtag    720

gcccgtgtgc gggcggcggc gcgggagcag cgcggagcgg cagccggctg gggcgggtgg    780

catcatggac gagaaggtgt tcaccaagga gctggaccag tggatcgagc agctgaacga    840

gtgcaagcag ctgtccgatt actgtctgtg gagatgtgca tgggcaattt catgatctca    900

tggaactgtt tagaattggt ggcaaatcac cagatacaaa ttacttgttt atgggagatt    960

atgttgacag aggatattat tcagttgaaa cagttacact gcttgtagct cttaaggttc   1020

gttaccgtga acgcatcacc attcttcgag ggaatcatga gagcagacag atcacacaag   1080

tttatggttt ctatgatgaa tgtttaagaa aatatggaaa tgcaaatgtt tggaaatatt   1140

ttacagatct ttttgactat cttcctctca ctgccttggt ggatgggcag atcttctgtc   1200

tacatggtgg tctctcgcca tctatagata cactggatca tatcagagca cttgatcgcc   1260

tacaagaagt tccccatgag ggtccaatgt gtgacttgct gtggtcagat ccagatgacc   1320

gtggtggttg gggtatatct cctcgaggag ctggttacac ctttgggcaa gatatttctg   1380

agacatttaa tcatgccaat ggcctcacgt tggtgtctag agctcaccag ctagtgatgg   1440

agggatataa ctggtgccat gaccggaatg tagtaacgat tttcagtgct ccaaactatt   1500

gttatcgttg tggtaaccaa gctgcaatca tggaacttga cgatactcta aaatactctt   1560

tcttgcagtt tgacccagca cctcgtagag gcgagccaca tgttactcgt cgtaccccag   1620

actacttcct gtaatgaaat tttaaacttg tacagtattg ccatgaacca tatatcgacc   1680

taatggaaat gggaagagca acagtaactc caaagtgtca gaaaatagtt aacattcaaa   1740

aaacttgttt tcacatggac caaaagatgt gccatataaa aatacaaagc ctcttgtcat   1800

caacagccgt gaccacttta gaatgaacca gttcattgca tgctgaagcg acattgttgg   1860

tcaagaaacc agtttctggc atagcgctat ttgtagttac ttttgctttc tctgagagac   1920

tgcagataat aagatgtaaa cattaacacc tcgtgaatac aatttaactt ccatttagct   1980

atagctttac tcagcatgac tgtagataag gatagcagca aacaatcatt ggagcttaat   2040

gaacattttt aaaaataatt accaaggcct cccttctact tgtgagtttt gaaattgttc   2100

tttttatttt cagggatacc gtttaattta attatatgat ttgtctgcac tcagtttatt   2160

ccctactcaa atctcagccc catgttgttc tttgttattg tcagaacctg gtgagttgtt   2220

ttgaacagaa ctgttttttc cccttcctgt aagacgatgt gactgcacaa gagcactgca   2280

gtgtttttca taataaactt gtgaactaag aactgagaag gtcaaatttt aattgt       2336


<210>  2965
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  2965

Met Glu Leu Phe Arg Ile Gly Gly Lys Ser Pro Asp Thr Asn Tyr Leu 
1               5                   10                  15


Phe Met Gly Asp Tyr Val Asp Arg Gly Tyr Tyr Ser Val Glu Thr Val 
            20                  25                  30


Thr Leu Leu Val Ala Leu Lys Val Arg Tyr Arg Glu Arg Ile Thr Ile 
        35                  40                  45


Leu Arg Gly Asn His Glu Ser Arg Gln Ile Thr Gln Val Tyr Gly Phe 
    50                  55                  60


Tyr Asp Glu Cys Leu Arg Lys Tyr Gly Asn Ala Asn Val Trp Lys Tyr 
65                  70                  75                  80


Phe Thr Asp Leu Phe Asp Tyr Leu Pro Leu Thr Ala Leu Val Asp Gly 
                85                  90                  95


Gln Ile Phe Cys Leu His Gly Gly Leu Ser Pro Ser Ile Asp Thr Leu 
            100                 105                 110


Asp His Ile Arg Ala Leu Asp Arg Leu Gln Glu Val Pro His Glu Gly 
        115                 120                 125


Pro Met Cys Asp Leu Leu Trp Ser Asp Pro Asp Asp Arg Gly Gly Trp 
    130                 135                 140


Gly Ile Ser Pro Arg Gly Ala Gly Tyr Thr Phe Gly Gln Asp Ile Ser 
145                 150                 155                 160


Glu Thr Phe Asn His Ala Asn Gly Leu Thr Leu Val Ser Arg Ala His 
                165                 170                 175


Gln Leu Val Met Glu Gly Tyr Asn Trp Cys His Asp Arg Asn Val Val 
            180                 185                 190


Thr Ile Phe Ser Ala Pro Asn Tyr Cys Tyr Arg Cys Gly Asn Gln Ala 
        195                 200                 205


Ala Ile Met Glu Leu Asp Asp Thr Leu Lys Tyr Ser Phe Leu Gln Phe 
    210                 215                 220


Asp Pro Ala Pro Arg Arg Gly Glu Pro His Val Thr Arg Arg Thr Pro 
225                 230                 235                 240


Asp Tyr Phe Leu 



<210>  2966
<211>  2416
<212>  DNA
<213>  Homo sapiens

<400>  2966
agaggtgggg gtggttaatc caagcggcca ctcgctgccc gttcctgccc ccaaagatga     60

cggaaaccca cacgattaca gagccgcagc accccagatg agccacgggg tcgcaattct    120

cgtttccgtg atcggactgc caggccccag gtgaggagct gagttcatca ccagagcggc    180

cttcccaggg gaaccagtta caggctgcca gtggccccgg cttccatccg gtctgcgcct    240

gcgcgcggcc caagccctcg cctctcctgg aatagtgctc agggattagt ccggttcgcc    300

gctgtgcgca ctgcgcatgc tccagctcca tccttccctt cccccaccac cccgccctcc    360

gggagccacg cccaaaaagt caaggcgctt cagttaccag ccggctacgt cgcgcctgcg    420

ctttgacccc cagtttgcgc cccaactccg gtcgtgcggc cgcccgggga gggctctgca    480

gttgcgcagc ttgctccccg gcccttttcc cctccgctcc ccgccgcctc ctgacgccgg    540

gcgtgacgtc accacgcccg gcggccgcca ttacagagag ccgagctctg gagcctcagc    600

gagcggagga ggaggcgcag cggccgacgg ccgagtactg cggtgagagc cagcgggcca    660

gcgccagcct caacagccgc cagaagtaca cgaggaaccg gcggcggcgt gtgcgtgtag    720

gcccgtgtgc gggcggcggc gcgggagcag cgcggagcgg cagccggctg gggcgggtgg    780

catcatggac gagaaggtgt tcaccaagga gctggaccag tggatcgagc agctgaacga    840

gtgcaagcag ctgtccgagt cccaggtcaa gagcctctgc gagaaggcta aagaaatcct    900

gacaaaagaa tccaacgtgc aagaggttcg atgtccagtt actgtctgtg gagatgtgca    960

tgggcaattt catgatctca tggaactgtt tagaattggt ggcaaatcac cagatacaaa   1020

ttacttgttt atgggagatt atgttgacag aggatattat tcagttgaaa cagttacact   1080

gcttgtagct cttaaggttc gttaccgtga acgcatcacc attcttcgag ggaatcatga   1140

gagcagacag atcacacaag tttatggttt ctatgatgaa tgtttaagaa aatatggaaa   1200

tgcaaatgtt tggaaatatt ttacagatct ttttgactat cttcctctca ctgccttggt   1260

ggatgggcag atcttctgtc tacatggtgg tctctcgcca tctatagata cactggatca   1320

tatcagagca cttgatcgcc tacaagaagt tccccatgag ggtccaatgt gtgacttgct   1380

gtggtcagat ccagatgacc gtggtggttg gggtatatct cctcgaggag ctggttacac   1440

ctttgggcaa gatatttctg agacatttaa tcatgccaat ggcctcacgt tggtgtctag   1500

agctcaccag ctagtgatgg agggatataa ctggtgccat gaccggaatg tagtaacgat   1560

tttcagtgct ccaaactatt gttatcgttg tggtaaccaa gctgcaatca tggaacttga   1620

cgatactcta aaatactctt tcttgcagtt tgacccagca cctcgtagag gcgagccaca   1680

tgttactcgt cgtaccccag actacttcct gtaatgaaat tttaaacttg tacagtattg   1740

ccatgaacca tatatcgacc taatggaaat gggaagagca acagtaactc caaagtgtca   1800

gaaaatagtt aacattcaaa aaacttgttt tcacatggac caaaagatgt gccatataaa   1860

aatacaaagc ctcttgtcat caacagccgt gaccacttta gaatgaacca gttcattgca   1920

tgctgaagcg acattgttgg tcaagaaacc agtttctggc atagcgctat ttgtagttac   1980

ttttgctttc tctgagagac tgcagataat aagatgtaaa cattaacacc tcgtgaatac   2040

aatttaactt ccatttagct atagctttac tcagcatgac tgtagataag gatagcagca   2100

aacaatcatt ggagcttaat gaacattttt aaaaataatt accaaggcct cccttctact   2160

tgtgagtttt gaaattgttc tttttatttt cagggatacc gtttaattta attatatgat   2220

ttgtctgcac tcagtttatt ccctactcaa atctcagccc catgttgttc tttgttattg   2280

tcagaacctg gtgagttgtt ttgaacagaa ctgttttttc cccttcctgt aagacgatgt   2340

gactgcacaa gagcactgca gtgtttttca taataaactt gtgaactaag aactgagaag   2400

gtcaaatttt aattgt                                                   2416


<210>  2967
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  2967

Met Asp Glu Lys Val Phe Thr Lys Glu Leu Asp Gln Trp Ile Glu Gln 
1               5                   10                  15


Leu Asn Glu Cys Lys Gln Leu Ser Glu Ser Gln Val Lys Ser Leu Cys 
            20                  25                  30


Glu Lys Ala Lys Glu Ile Leu Thr Lys Glu Ser Asn Val Gln Glu Val 
        35                  40                  45


Arg Cys Pro Val Thr Val Cys Gly Asp Val His Gly Gln Phe His Asp 
    50                  55                  60


Leu Met Glu Leu Phe Arg Ile Gly Gly Lys Ser Pro Asp Thr Asn Tyr 
65                  70                  75                  80


Leu Phe Met Gly Asp Tyr Val Asp Arg Gly Tyr Tyr Ser Val Glu Thr 
                85                  90                  95


Val Thr Leu Leu Val Ala Leu Lys Val Arg Tyr Arg Glu Arg Ile Thr 
            100                 105                 110


Ile Leu Arg Gly Asn His Glu Ser Arg Gln Ile Thr Gln Val Tyr Gly 
        115                 120                 125


Phe Tyr Asp Glu Cys Leu Arg Lys Tyr Gly Asn Ala Asn Val Trp Lys 
    130                 135                 140


Tyr Phe Thr Asp Leu Phe Asp Tyr Leu Pro Leu Thr Ala Leu Val Asp 
145                 150                 155                 160


Gly Gln Ile Phe Cys Leu His Gly Gly Leu Ser Pro Ser Ile Asp Thr 
                165                 170                 175


Leu Asp His Ile Arg Ala Leu Asp Arg Leu Gln Glu Val Pro His Glu 
            180                 185                 190


Gly Pro Met Cys Asp Leu Leu Trp Ser Asp Pro Asp Asp Arg Gly Gly 
        195                 200                 205


Trp Gly Ile Ser Pro Arg Gly Ala Gly Tyr Thr Phe Gly Gln Asp Ile 
    210                 215                 220


Ser Glu Thr Phe Asn His Ala Asn Gly Leu Thr Leu Val Ser Arg Ala 
225                 230                 235                 240


His Gln Leu Val Met Glu Gly Tyr Asn Trp Cys His Asp Arg Asn Val 
                245                 250                 255


Val Thr Ile Phe Ser Ala Pro Asn Tyr Cys Tyr Arg Cys Gly Asn Gln 
            260                 265                 270


Ala Ala Ile Met Glu Leu Asp Asp Thr Leu Lys Tyr Ser Phe Leu Gln 
        275                 280                 285


Phe Asp Pro Ala Pro Arg Arg Gly Glu Pro His Val Thr Arg Arg Thr 
    290                 295                 300


Pro Asp Tyr Phe Leu 
305


<210>  2968
<211>  1136
<212>  DNA
<213>  Homo sapiens

<400>  2968
agaggtgggg gtggttaatc caagcggcca ctcgctgccc gttcctgccc ccaaagatga     60

cggaaaccca cacgattaca gagccgcagc accccagatg agccacgggg tcgcaattct    120

cgtttccgtg atcggactgc caggccccag gtgaggagct gagttcatca ccagagcggc    180

cttcccaggg gaaccagtta caggctgcca gtggccccgg cttccatccg gtctgcgcct    240

gcgcgcggcc caagccctcg cctctcctgg aatagtgctc agggattagt ccggttcgcc    300

gctgtgcgca ctgcgcatgc tccagctcca tccttccctt cccccaccac cccgccctcc    360

gggagccacg cccaaaaagt caaggcgctt cagttaccag ccggctacgt cgcgcctgcg    420

ctttgacccc cagtttgcgc cccaactccg gtcgtgcggc cgcccgggga gggctctgca    480

gttgcgcagc ttgctccccg gcccttttcc cctccgctcc ccgccgcctc ctgacgccgg    540

gcgtgacgtc accacgcccg gcggccgcca ttacagagag ccgagctctg gagcctcagc    600

gagcggagga ggaggcgcag cggccgacgg ccgagtactg cggtgagagc cagcgggcca    660

gcgccagcct caacagccgc cagaagtaca cgaggaaccg gcggcggcgt gtgcgtgtag    720

gcccgtgtgc gggcggcggc gcgggagcag cgcggagcgg cagccggctg gggcgggtgg    780

catcatggac gagaaggtgt tcaccaagga gctggaccag tggatcgagc agctgaacga    840

gtgcaagcag ctgtccgagt cccaggtcaa gagcctctgc gagaaggcta aagaaatcct    900

gacaaaagaa tccaacgtgc aagaggttcg atgtccagtt actgtctgtg gagatgtgca    960

tgggcaattt catgatctca tggaactgtt tagaattggt ggcaaatcac cagatacaaa   1020

ttacttgttt atgggagatt atgttgacag aggatattat tcagttgaaa cagttacact   1080

gcttgtagct cttaagagat taggacacag atggggagaa gataagacag atggag       1136


<210>  2969
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  2969

Met Asp Glu Lys Val Phe Thr Lys Glu Leu Asp Gln Trp Ile Glu Gln 
1               5                   10                  15


Leu Asn Glu Cys Lys Gln Leu Ser Glu Ser Gln Val Lys Ser Leu Cys 
            20                  25                  30


Glu Lys Ala Lys Glu Ile Leu Thr Lys Glu Ser Asn Val Gln Glu Val 
        35                  40                  45


Arg Cys Pro Val Thr Val Cys Gly Asp Val His Gly Gln Phe His Asp 
    50                  55                  60


Leu Met Glu Leu Phe Arg Ile Gly Gly Lys Ser Pro Asp Thr Asn Tyr 
65                  70                  75                  80


Leu Phe Met Gly Asp Tyr Val Asp Arg Gly Tyr Tyr Ser Val Glu Thr 
                85                  90                  95


Val Thr Leu Leu Val Ala Leu Lys Arg Leu Gly His Arg Trp Gly Glu 
            100                 105                 110


Asp Lys Thr Asp 
        115


<210>  2970
<211>  2065
<212>  DNA
<213>  Homo sapiens

<400>  2970
agaggtgggg gtggttaatc caagcggcca ctcgctgccc gttcctgccc ccaaagatga     60

cggaaaccca cacgattaca gagccgcagc accccagatg agccacgggg tcgcaattct    120

cgtttccgtg atcggactgc caggccccag gtgaggagct gagttcatca ccagagcggc    180

cttcccaggg gaaccagtta caggctgcca gtggccccgg cttccatccg gtctgcgcct    240

gcgcgcggcc caagccctcg cctctcctgg aatagtgctc agggattagt ccggttcgcc    300

gctgtgcgca ctgcgcatgc tccagctcca tccttccctt cccccaccac cccgccctcc    360

gggagccacg cccaaaaagt caaggcgctt cagttaccag ccggctacgt cgcgcctgcg    420

ctttgacccc cagtttgcgc cccaactccg gtcgtgcggc cgcccgggga gggctctgca    480

gttgcgcagc ttgctccccg gcccttttcc cctccgctcc ccgccgcctc ctgacgccgg    540

gcgtgacgtc accacgcccg gcggccgcca ttacagagag ccgagctctg gagcctcagc    600

gagcggagga ggaggcgcag cggccgacgg ccgagtactg cggtgagagc cagcgggcca    660

gcgccagcct caacagccgc cagaagtaca cgaggaaccg gcggcggcgt gtgcgtgtag    720

gcccgtgtgc gggcggcggc gcgggagcag cgcggagcgg cagccggctg gggcgggtgg    780

catcatggac gagaaggtgt tcaccaagga gctggaccag tggatcgagc agctgaacga    840

gtgcaagcag ctgtccgagt cccaggtcaa gagcctctgc gagaaggcta aagaaatcct    900

gacaaaagaa tccaacgtgc aagaggttcg atgtccagtt actgtctgtg gagatgtgca    960

tgggcaattt catgatctca tggaactgtt tagaattggt ggcaaatcac cagatacaaa   1020

ttacttgttt atgggagatt atgttgacag aggatattat tcagttgaaa cagttacact   1080

gcttgtagct cttaaggtaa tttcaatttt atgttggggc atgttgaaat gggtaagaca   1140

gtcctcttga aagttttttt tcccccagtt attttctcta tctgaatgtt aaaacaaaat   1200

tccacattta ggaatgcata tgttcaggtt ttggacttaa aaatcatagg cgtctgcgtt   1260

ctgagtaagg ggatggtaca gaatcaaaac aaaaggagga gaatgaatgc ctcagtcaga   1320

ttgtttgaaa aaataggctg ggcgtgatgg cttatgcctg taatcccagc actttgggac   1380

gctgaggtag gcagatcacc tgaggtcagg agttcgagac cagcctggag aacatggtga   1440

agccccatct ctactaaaag tacaaaaaac tagccggggg tggtggcggg tgcctgtaat   1500

cccagctact ctggagcctg aggcaggaga attgcttgaa cctgggaggc ggaggttgca   1560

gtgagctgag attgcgccac tacacgccag cctggacaac agagcgagac tgtctcaaaa   1620

aaaaaaaaag gaaaagaaaa atgttagagg gctggtcaaa tagatatttt agttcagtaa   1680

attggggtat ggagaggtaa tataattaga tttgtgtttt tagatacttt tgaagtatta   1740

taaatatata aacataccaa atgtcaaaat gttttaaatc agctggtcac ggtggctcgt   1800

ggctataatc ccagcacttt gggaggacag gacaaagtga gcatattgct tgagtccaag   1860

agtttgtgac cagcctgggc aacatagtga gaccttgtct acaaaaaaat aataataatt   1920

aaccgagtgt ggtggcacag gcctgtagtc ccagctactc aggctgaggt gggcagagtt   1980

gcctgagccc aggaggtcgt ggctgcaatg agacttgatc ttgccaccct acactctaac   2040

ttggggaaca atgagaccct gtctc                                         2065


<210>  2971
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  2971

Met Asp Glu Lys Val Phe Thr Lys Glu Leu Asp Gln Trp Ile Glu Gln 
1               5                   10                  15


Leu Asn Glu Cys Lys Gln Leu Ser Glu Ser Gln Val Lys Ser Leu Cys 
            20                  25                  30


Glu Lys Ala Lys Glu Ile Leu Thr Lys Glu Ser Asn Val Gln Glu Val 
        35                  40                  45


Arg Cys Pro Val Thr Val Cys Gly Asp Val His Gly Gln Phe His Asp 
    50                  55                  60


Leu Met Glu Leu Phe Arg Ile Gly Gly Lys Ser Pro Asp Thr Asn Tyr 
65                  70                  75                  80


Leu Phe Met Gly Asp Tyr Val Asp Arg Gly Tyr Tyr Ser Val Glu Thr 
                85                  90                  95


Val Thr Leu Leu Val Ala Leu Lys Val Ile Ser Ile Leu Cys Trp Gly 
            100                 105                 110


Met Leu Lys Trp Val Arg Gln Ser Ser 
        115                 120


<210>  2972
<211>  922
<212>  DNA
<213>  Homo sapiens

<400>  2972
agaacgggtc acgtgagcgc ctcgcctgga tgtgagtttc agccagagcc aaatggagaa     60

gggtatattt aatgagcgaa caggtcacag tgaccaaatg gcaaatgaga acaaaaggaa    120

gctgaatttt tccagatctg acaggaaaga attccatttt ccagaattgc ctgtcacaat    180

acagtcaaaa gatacaaaag gaatggaagt taaacagata aaaatgctga agagggagtc    240

aaagaaaaca gagtcatcta agataccaac tttacttaac gtggatcaaa atcaagaaaa    300

acaagagggt ggagatggcc attgcgaggg gaagaatttg aagagaaaca ggtttttttt    360

ctggtagtgt cttttctttt acatagtcca aaaaatacaa gatgacaact cttcccgttt    420

tatttatcta caatagaagt gtgatgtgag ttgttgttaa gacagccatc catgtgcatg    480

agcatcatcc agcttttttt gttagcaaaa catttactgt tttcttttcc cttttaagac    540

tctgttgatg tgataatttg atttggaatt ataaagtcat ctcttctctg cctacttctt    600

ttttttgcca tgattactga gtggataaca caagccgtga catgatacaa actgtactta    660

tacttaatga tctctgcctt cttgtagcca cataacttcg agtcagttat ctcctataac    720

acacaggcct ctttaaatga gttcttaata aaatatttga gccgttgttt taaaagctat    780

tcatggctgg gtgcaatggc tcatgcctgt aatcccaaca ctttgggagg ctgaggcagg    840

cggatcactt gaggtcagga gttcgaaacc agcctgacca acacggtgaa acaccatctc    900

tactaaaaat gcaaaaatta gc                                             922


<210>  2973
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  2973

Met Glu Lys Gly Ile Phe Asn Glu Arg Thr Gly His Ser Asp Gln Met 
1               5                   10                  15


Ala Asn Glu Asn Lys Arg Lys Leu Asn Phe Ser Arg Ser Asp Arg Lys 
            20                  25                  30


Glu Phe His Phe Pro Glu Leu Pro Val Thr Ile Gln Ser Lys Asp Thr 
        35                  40                  45


Lys Gly Met Glu Val Lys Gln Ile Lys Met Leu Lys Arg Glu Ser Lys 
    50                  55                  60


Lys Thr Glu Ser Ser Lys Ile Pro Thr Leu Leu Asn Val Asp Gln Asn 
65                  70                  75                  80


Gln Glu Lys Gln Glu Gly Gly Asp Gly His Cys Glu Gly Lys Asn Leu 
                85                  90                  95


Lys Arg Asn Arg Phe Phe Phe Trp 
            100


<210>  2974
<211>  2129
<212>  DNA
<213>  Homo sapiens

<400>  2974
ggaactacgc agagccagac cagcgggacc acagaatggg ctgaggcggc ggcggctgtt     60

tggataaagt caacagcggg acgtggggcg tgacgccgta gtaaaagccc agcttgaaaa    120

tggagatgta tgaaaccctt ggaaaagtgg gagagggaag ttacggaaca gtcatgaaat    180

gtaaacataa gaatactggg cagatagtgg ccattaagat attttatgag agaccagaac    240

aatctgtcaa caaaattgcg atgagagaaa taaagtttct aaagcaattt catcacgaaa    300

acctggtcaa tctgattgaa gtttttagac agaaaaagaa aattcatttg gtatttgaat    360

ttattgacca cacagtatta gatgagttac aacattattg tcatggacta gagagtaagc    420

gacttagaaa atacctcttc cagatccttc gagcaattga ctatcttcac agtaataata    480

tcattcatcg agatataaaa cctgagaata ttttagtatc ccagtcagga attactaagc    540

tctgtgattt tggttttgca cgaacactag cagctcctgg ggacatttat acggactatg    600

tggccacacg ctggtataga gctcccgaat tagtattaaa agatacttct tatggaaaac    660

ctgtggatat ctgggctttg ggctgtatga tcattgagat ggccactgga aatccctatc    720

ttcctagtag ttctgatttg gatttactcc ataaaattgt tttgaaagtg ggcaatttgt    780

cacctcactt gcagaatatc ttttccaaga gccccatttt tgctggggta gttcttcctc    840

aagttcaaca ccccaaaaat gcaagaaaaa aatatccaaa gcttaatgga ttgttggcag    900

atatagttca tgcttgttta caaattgatc ctgctgacag gatatcatct agtgatcttt    960

tgcatcatga gtattttact agagatggat ttattgaaaa attcatgcca gaactgaaag   1020

ctaaattact gcaggaagca aaagtcaatt cattaataaa gccaaaagag agttctaaag   1080

aaaatgaact caggaaagat gaaagaaaaa cagtttatac caatacactg ctaagtagtt   1140

cagttttggg aaaggaaata gaaaaagaga aaaagcccaa ggagatcaaa gtcagagtta   1200

ttaaagtcaa aggaggaaga ggagatatct cagaaccaaa aaagaaagag tatgaaggtg   1260

gacttggtca acaggatgca aatgaaaatg ttcatcctat gtctccagat acaaaacttg   1320

taaccattga accaccaaac cctatcaatc ccagcactaa ctgtaatggc ttgaaagaaa   1380

atccacattg cggaggttct gtgacaatgc cacccatcaa tctaactaac agtaatttga   1440

tggctgcaaa tctcagttca aatctctttc accccagtgt gaggttaact gaaagagcaa   1500

aaaagagacg cacttcttca caatctattg gacaagttat gcctaatagc aggcaagagg   1560

atccaggtcc tattcaaagc caaatggaga agggtatatt taatgagcga acaggtcaca   1620

gtgaccaaat ggcaaatgag aacaaaagga agctgaattt ttccagatct gacaggaaag   1680

aattccattt tccagaattg cctgtcacaa tacagtcaaa agatacaaaa ggaatggaag   1740

ttaaacagat aaaaatgctg aagagggagt caaagaaaac agagtcatct aagataccaa   1800

ctttacttaa cgtggatcaa aatcaagaaa aacaagaggg tggagatggc cattgcgagg   1860

ggaagaattt gaagagaaac aggttttttt tctggtagtg tcttttcttt tacatagtcc   1920

aaaaaataca agatgacaac tcttcccgtt ttatttatct acaatagaag tgtgatgtga   1980

gttgttgtta agacagccat ccatgtgcat gagcatcatc cagctttttt tgttagcaaa   2040

acatttactg ttttcttttc ccttttaaga ctctgttgat gtgataattt gatttggaat   2100

tataaagtca tctcttctct gcctacttc                                     2129


<210>  2975
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  2975

Met Glu Met Tyr Glu Thr Leu Gly Lys Val Gly Glu Gly Ser Tyr Gly 
1               5                   10                  15


Thr Val Met Lys Cys Lys His Lys Asn Thr Gly Gln Ile Val Ala Ile 
            20                  25                  30


Lys Ile Phe Tyr Glu Arg Pro Glu Gln Ser Val Asn Lys Ile Ala Met 
        35                  40                  45


Arg Glu Ile Lys Phe Leu Lys Gln Phe His His Glu Asn Leu Val Asn 
    50                  55                  60


Leu Ile Glu Val Phe Arg Gln Lys Lys Lys Ile His Leu Val Phe Glu 
65                  70                  75                  80


Phe Ile Asp His Thr Val Leu Asp Glu Leu Gln His Tyr Cys His Gly 
                85                  90                  95


Leu Glu Ser Lys Arg Leu Arg Lys Tyr Leu Phe Gln Ile Leu Arg Ala 
            100                 105                 110


Ile Asp Tyr Leu His Ser Asn Asn Ile Ile His Arg Asp Ile Lys Pro 
        115                 120                 125


Glu Asn Ile Leu Val Ser Gln Ser Gly Ile Thr Lys Leu Cys Asp Phe 
    130                 135                 140


Gly Phe Ala Arg Thr Leu Ala Ala Pro Gly Asp Ile Tyr Thr Asp Tyr 
145                 150                 155                 160


Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu Leu Val Leu Lys Asp Thr 
                165                 170                 175


Ser Tyr Gly Lys Pro Val Asp Ile Trp Ala Leu Gly Cys Met Ile Ile 
            180                 185                 190


Glu Met Ala Thr Gly Asn Pro Tyr Leu Pro Ser Ser Ser Asp Leu Asp 
        195                 200                 205


Leu Leu His Lys Ile Val Leu Lys Val Gly Asn Leu Ser Pro His Leu 
    210                 215                 220


Gln Asn Ile Phe Ser Lys Ser Pro Ile Phe Ala Gly Val Val Leu Pro 
225                 230                 235                 240


Gln Val Gln His Pro Lys Asn Ala Arg Lys Lys Tyr Pro Lys Leu Asn 
                245                 250                 255


Gly Leu Leu Ala Asp Ile Val His Ala Cys Leu Gln Ile Asp Pro Ala 
            260                 265                 270


Asp Arg Ile Ser Ser Ser Asp Leu Leu His His Glu Tyr Phe Thr Arg 
        275                 280                 285


Asp Gly Phe Ile Glu Lys Phe Met Pro Glu Leu Lys Ala Lys Leu Leu 
    290                 295                 300


Gln Glu Ala Lys Val Asn Ser Leu Ile Lys Pro Lys Glu Ser Ser Lys 
305                 310                 315                 320


Glu Asn Glu Leu Arg Lys Asp Glu Arg Lys Thr Val Tyr Thr Asn Thr 
                325                 330                 335


Leu Leu Ser Ser Ser Val Leu Gly Lys Glu Ile Glu Lys Glu Lys Lys 
            340                 345                 350


Pro Lys Glu Ile Lys Val Arg Val Ile Lys Val Lys Gly Gly Arg Gly 
        355                 360                 365


Asp Ile Ser Glu Pro Lys Lys Lys Glu Tyr Glu Gly Gly Leu Gly Gln 
    370                 375                 380


Gln Asp Ala Asn Glu Asn Val His Pro Met Ser Pro Asp Thr Lys Leu 
385                 390                 395                 400


Val Thr Ile Glu Pro Pro Asn Pro Ile Asn Pro Ser Thr Asn Cys Asn 
                405                 410                 415


Gly Leu Lys Glu Asn Pro His Cys Gly Gly Ser Val Thr Met Pro Pro 
            420                 425                 430


Ile Asn Leu Thr Asn Ser Asn Leu Met Ala Ala Asn Leu Ser Ser Asn 
        435                 440                 445


Leu Phe His Pro Ser Val Arg Leu Thr Glu Arg Ala Lys Lys Arg Arg 
    450                 455                 460


Thr Ser Ser Gln Ser Ile Gly Gln Val Met Pro Asn Ser Arg Gln Glu 
465                 470                 475                 480


Asp Pro Gly Pro Ile Gln Ser Gln Met Glu Lys Gly Ile Phe Asn Glu 
                485                 490                 495


Arg Thr Gly His Ser Asp Gln Met Ala Asn Glu Asn Lys Arg Lys Leu 
            500                 505                 510


Asn Phe Ser Arg Ser Asp Arg Lys Glu Phe His Phe Pro Glu Leu Pro 
        515                 520                 525


Val Thr Ile Gln Ser Lys Asp Thr Lys Gly Met Glu Val Lys Gln Ile 
    530                 535                 540


Lys Met Leu Lys Arg Glu Ser Lys Lys Thr Glu Ser Ser Lys Ile Pro 
545                 550                 555                 560


Thr Leu Leu Asn Val Asp Gln Asn Gln Glu Lys Gln Glu Gly Gly Asp 
                565                 570                 575


Gly His Cys Glu Gly Lys Asn Leu Lys Arg Asn Arg Phe Phe Phe Trp 
            580                 585                 590


<210>  2976
<211>  434
<212>  DNA
<213>  Homo sapiens

<400>  2976
gcccgcggcc ttgtcaacaa tccacccctg agtgggaggg ggagaagtat ctagaaccac     60

gtgtccctat gacgcgttta gaacgggtca cgtgagcgcc tcgcctggat gtgagtttca    120

gccagacctg tggatatctg ggctttgggc tgtatgatca ttgagatggc cactggaaat    180

ccctatcttc ctagtagttc tgatttggat ttactccata aaattgtttt gaaagtgggc    240

aatttgtcac ctcacttgca gaatatcttt tccaagagcc ccatttttgc tggggtagtt    300

cttcctcaag ttcaacaccc caaaaatgca agaaaaaaat atccaaagct taatggattg    360

ttggcagata tagttcatag ccaaatggag aagggtatat ttaatgagcg aacaggtcac    420

agtgaccaaa tggc                                                      434


<210>  2977
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  2977

Met Ile Ile Glu Met Ala Thr Gly Asn Pro Tyr Leu Pro Ser Ser Ser 
1               5                   10                  15


Asp Leu Asp Leu Leu His Lys Ile Val Leu Lys Val Gly Asn Leu Ser 
            20                  25                  30


Pro His Leu Gln Asn Ile Phe Ser Lys Ser Pro Ile Phe Ala Gly Val 
        35                  40                  45


Val Leu Pro Gln Val Gln His Pro Lys Asn Ala Arg Lys Lys Tyr Pro 
    50                  55                  60


Lys Leu Asn Gly Leu Leu Ala Asp Ile Val His Ser Gln Met Glu Lys 
65                  70                  75                  80


Gly Ile Phe Asn Glu Arg Thr Gly His Ser Asp Gln 
                85                  90


<210>  2978
<211>  699
<212>  DNA
<213>  Homo sapiens

<400>  2978
cagacctgtg gatatctggg ctttgggctg tatgatcatt gagatggcca ctggaaatcc     60

ctatcttcct agtagttctg atttggattt actccataaa attgttttga aagtgggaaa    120

tagaaaaaga gaaaaagccc aaggagatca aagtcagagt tattaaagtc aaaggaggaa    180

gaggagatat ctcagaacca aaaaagaaag agtatgaagg tggacttggt caacaggatg    240

caaatgaaaa tgttcatcct atgtctccag atacaaaact tgtaaccatt gaaccaccaa    300

accctatcaa tcccagcact aactgtaatg gcttgaaaga aaatccacat tgcggaggtt    360

ctgtgacaat gccacccatc aatctaacta acagtaattt gatggctgca aatctcagtt    420

caaatctctt tcaccccagt gtgaggtgag ctgtaacaga gaagaaacct aaataataca    480

acattcctgt ataatggtat ttcaaagaat cgtgttcata gtgtctgtat gtaaactgaa    540

cttgaagaaa atatattgaa attaaagctg tataatgggc catttactga gtgtttctta    600

tggatgctgt agaagaaatt aacttttctt ggccatatag atgtttaaat tttcactaat    660

gtcttcttga aaaaccttat taaaaaaaaa gaccctttg                           699


<210>  2979
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  2979

Met Ile Ile Glu Met Ala Thr Gly Asn Pro Tyr Leu Pro Ser Ser Ser 
1               5                   10                  15


Asp Leu Asp Leu Leu His Lys Ile Val Leu Lys Val Gly Asn Arg Lys 
            20                  25                  30


Arg Glu Lys Ala Gln Gly Asp Gln Ser Gln Ser Tyr 
        35                  40


<210>  2980
<211>  975
<212>  DNA
<213>  Homo sapiens

<400>  2980
gtttagaacg ggtcacgtga gcgcctcgcc tggatgtgag tttcagccag acctgtggat     60

atctgggctt tgggctgtat gatcattgag atggccactg gaaatcccta tcttcctagt    120

agttctgatt tggatttact ccataaaatt gttttgaaag tgggcaattt gtcacctcac    180

ttgcagaata tcttttccaa gagccccatt tttgctgggg tagttcttcc tcaagttcaa    240

caccccaaaa atgcaagaaa aaaatatcca aagcttaatg gattgttggc agatatagtt    300

catgcttgtt tacaaattga tcctgctgac aggatatcat ctagtgatct tttgcatcat    360

gagtatttta ctagagatgg atttattgaa aagaaataga aaaagagaaa aagcccaagg    420

agatcaaagt cagagttatt aaagtcaaag gaggaagagg agatatctca gaaccaaaaa    480

agaaagagta tgaaggtgga cttggtcaac aggatgcaaa tgaaaatgtt catcctatgt    540

ctccagatac aaaacttgta accattgaac caccaaaccc tatcaatccc agcactaact    600

gtaatggctt gaaagaaaat ccacattgcg gaggttctgt gacaatgcca cccatcaatc    660

taactaacag taatttgatg gctgcaaatc tcagttcaaa tctctttcac cccagtgtga    720

ggtgagctgt aacagagaag aaacctaaat aatacaacat tcctgtataa tggtatttca    780

aagaatcgtg ttcatagtgt ctgtatgtaa actgaacttg aagaaaatat attgaaatta    840

aagctgtata atgggccatt tactgagtgt ttcttatgga tgctgtagaa gaaattaact    900

tttcttggcc atatagatgt ttaaattttc actaatgtct tcttgaaaaa ccttattaaa    960

aaaaaagacc ctttg                                                     975


<210>  2981
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  2981

Met Ile Ile Glu Met Ala Thr Gly Asn Pro Tyr Leu Pro Ser Ser Ser 
1               5                   10                  15


Asp Leu Asp Leu Leu His Lys Ile Val Leu Lys Val Gly Asn Leu Ser 
            20                  25                  30


Pro His Leu Gln Asn Ile Phe Ser Lys Ser Pro Ile Phe Ala Gly Val 
        35                  40                  45


Val Leu Pro Gln Val Gln His Pro Lys Asn Ala Arg Lys Lys Tyr Pro 
    50                  55                  60


Lys Leu Asn Gly Leu Leu Ala Asp Ile Val His Ala Cys Leu Gln Ile 
65                  70                  75                  80


Asp Pro Ala Asp Arg Ile Ser Ser Ser Asp Leu Leu His His Glu Tyr 
                85                  90                  95


Phe Thr Arg Asp Gly Phe Ile Glu Lys Lys 
            100                 105


<210>  2982
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  2982
agcttaatgg attgttggca gatatagttc atattcatgc cagaactgaa agctaaatta     60

ctgcaggaag caaaagtcaa ttcattaata aagccaaaag agagttctaa agaaaatgaa    120

ctcaggaaag atgaaagaaa aacagtttat accaatacac tgctaagtag ttcagttttg    180

ggaaaggaaa tagaaaaaga gaaaaagccc aaggagatca aagtcagagt tattaaagtc    240

aaaggaggaa gaggagatat ctcagaacca aaaaagaaag agtatgaagg tggacttggt    300

caacaggatg caaatgaaaa tgttcatcct atgtctccag atacaaaact tgtaaccatt    360

gaaccaccaa accctatcaa tcccagcact aactgtaatg gcttgaaaga aaatccacat    420

tgcggaggtt ctgtgacaat gccacccatc aatctaacta acagtaattt gatggctgca    480

aatctcagtt caaatctctt tcaccccagt gtgaggtgag ctgtaacaga gaagaaacct    540

aaataataca acattcctgt ataatggtat ttcaaagaat cgtgttcata gtgtctgtat    600

gtaaactgaa cttgaagaaa atatattgaa attaaagctg tataatgggc c             651


<210>  2983
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  2983

Met Pro Glu Leu Lys Ala Lys Leu Leu Gln Glu Ala Lys Val Asn Ser 
1               5                   10                  15


Leu Ile Lys Pro Lys Glu Ser Ser Lys Glu Asn Glu Leu Arg Lys Asp 
            20                  25                  30


Glu Arg Lys Thr Val Tyr Thr Asn Thr Leu Leu Ser Ser Ser Val Leu 
        35                  40                  45


Gly Lys Glu Ile Glu Lys Glu Lys Lys Pro Lys Glu Ile Lys Val Arg 
    50                  55                  60


Val Ile Lys Val Lys Gly Gly Arg Gly Asp Ile Ser Glu Pro Lys Lys 
65                  70                  75                  80


Lys Glu Tyr Glu Gly Gly Leu Gly Gln Gln Asp Ala Asn Glu Asn Val 
                85                  90                  95


His Pro Met Ser Pro Asp Thr Lys Leu Val Thr Ile Glu Pro Pro Asn 
            100                 105                 110


Pro Ile Asn Pro Ser Thr Asn Cys Asn Gly Leu Lys Glu Asn Pro His 
        115                 120                 125


Cys Gly Gly Ser Val Thr Met Pro Pro Ile Asn Leu Thr Asn Ser Asn 
    130                 135                 140


Leu Met Ala Ala Asn Leu Ser Ser Asn Leu Phe His Pro Ser Val Arg 
145                 150                 155                 160


<210>  2984
<211>  581
<212>  DNA
<213>  Homo sapiens

<400>  2984
cagacctgtg gatatctggg ctttgggctg tatgatcatt gagatggcca ctggaaatcc     60

ctatcttcct agtagttctg atttggattt actccataaa attgttttga aagtgggaaa    120

tagaaaaaga gaaaaagccc aaggagatca aagtcagagt tattaaagtc aaaggaggaa    180

gaggagatat ctcagaacca aaaaagaaag agtatgaagg tggacttggt caacaggatg    240

caaatgaaaa tgttcatcct atgtctccag atacaaaact tgtaaccatt gaaccaccaa    300

accctatcaa tcccagcact aactgtaatg gcttgaaaga aaatccacat tgcggaggtt    360

ctgtgacaat gccacccatc aatctaacta acagtaattt gatggctgca aatctcagtt    420

caaatctctt tcaccccagt gtgaggtgag ctgtaacaga gaagaaacct aaataataca    480

acattcctgt ataatggtat ttcaaagaat cgtgttcata gtgtctgtat gtaaactgaa    540

cttgaagaaa atatattgaa attaaagctg tataatgggc c                        581


<210>  2985
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  2985

Met Ile Ile Glu Met Ala Thr Gly Asn Pro Tyr Leu Pro Ser Ser Ser 
1               5                   10                  15


Asp Leu Asp Leu Leu His Lys Ile Val Leu Lys Val Gly Asn Arg Lys 
            20                  25                  30


Arg Glu Lys Ala Gln Gly Asp Gln Ser Gln Ser Tyr 
        35                  40


<210>  2986
<211>  1619
<212>  DNA
<213>  Homo sapiens

<400>  2986
ggaactacgc agagccagac cagcgggacc acagaatggg ctgaggcggc ggcggctgtt     60

tggataaagt caacagcggg acgtggggcg tgacgccgta gtaaaagccc agcttgaaaa    120

tggagatgta tgaaaccctt ggaaaagtgg gagagggaag ttacggaaca gtcatgaaat    180

gtaaacataa gaatactggg cagatagtgg ccattaagat attttatgag agaccagaac    240

aatctgtcaa caaaattgcg atgagagaaa taaagtttct aaagcaattt catcacgaaa    300

acctggtcaa tctgattgaa gtttttagac agaaaaagaa aattcatttg gtatttgaat    360

ttattgacca cacagtatta gatgagttac aacattattg tcatggacta gagagtaagc    420

gacttagaaa atacctcttc cagatccttc gagcaattga ctatcttcac agtaataata    480

tcattcatcg agatataaaa cctgagaata ttttagtatc ccagtcagga attactaagc    540

tctgtgattt tggttttgca cgaacactag cagctcctgg ggacatttat acggactatg    600

tggccacacg ctggtataga gctcccgaat tagtattaaa agatacttct tatggaaaac    660

ctgtggatat ctgggctttg ggctgtatga tcattgagat ggccactgga aatccctatc    720

ttcctagtag ttctgatttg gatttactcc ataaaattgt tttgaaagtg ggcaatttgt    780

cacctcactt gcagaatatc ttttccaaga gccccatttt tgctggggta gttcttcctc    840

aagttcaaca ccccaaaaat gcaagaaaaa aatatccaaa gcttaatgga ttgttggcag    900

atatagttca tgcttgttta caaattgatc ctgctgacag gatatcatct agtgatcttt    960

tgcatcatga gtattttact agagatggat ttattgaaaa attcatgcca gaactgaaag   1020

ctaaattact gcaggaagca aaagtcaatt cattaataaa gccaaaagag agttctaaag   1080

aaaatgaact caggaaagat gaaagaaaaa cagtttatac caatacactg ctaagtagtt   1140

cagttttggg aaaggaaata gaaaaagaga aaaagcccaa ggagatcaaa gtcagagtta   1200

ttaaagtcaa aggaggaaga ggagatatct cagaaccaaa aaagaaagag tatgaaggtg   1260

gacttggtca acaggatgca aatgaaaatg ttcatcctat gtctccagat acaaaacttg   1320

taaccattga accaccaaac cctatcaatc ccagcactaa ctgtaatggc ttgaaagaaa   1380

atccacattg cggaggttct gtgacaatgc cacccatcaa tctaactaac agtaatttga   1440

tggctgcaaa tctcagttca aatctctttc accccagtgt gaggtgagct gtaacagaga   1500

agaaacctaa ataatacaac attcctgtat aatggtattt caaagaatcg tgttcatagt   1560

gtctgtatgt aaactgaact tgaagaaaat atattgaaat taaagctgta taatgggcc    1619


<210>  2987
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  2987

Met Glu Met Tyr Glu Thr Leu Gly Lys Val Gly Glu Gly Ser Tyr Gly 
1               5                   10                  15


Thr Val Met Lys Cys Lys His Lys Asn Thr Gly Gln Ile Val Ala Ile 
            20                  25                  30


Lys Ile Phe Tyr Glu Arg Pro Glu Gln Ser Val Asn Lys Ile Ala Met 
        35                  40                  45


Arg Glu Ile Lys Phe Leu Lys Gln Phe His His Glu Asn Leu Val Asn 
    50                  55                  60


Leu Ile Glu Val Phe Arg Gln Lys Lys Lys Ile His Leu Val Phe Glu 
65                  70                  75                  80


Phe Ile Asp His Thr Val Leu Asp Glu Leu Gln His Tyr Cys His Gly 
                85                  90                  95


Leu Glu Ser Lys Arg Leu Arg Lys Tyr Leu Phe Gln Ile Leu Arg Ala 
            100                 105                 110


Ile Asp Tyr Leu His Ser Asn Asn Ile Ile His Arg Asp Ile Lys Pro 
        115                 120                 125


Glu Asn Ile Leu Val Ser Gln Ser Gly Ile Thr Lys Leu Cys Asp Phe 
    130                 135                 140


Gly Phe Ala Arg Thr Leu Ala Ala Pro Gly Asp Ile Tyr Thr Asp Tyr 
145                 150                 155                 160


Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu Leu Val Leu Lys Asp Thr 
                165                 170                 175


Ser Tyr Gly Lys Pro Val Asp Ile Trp Ala Leu Gly Cys Met Ile Ile 
            180                 185                 190


Glu Met Ala Thr Gly Asn Pro Tyr Leu Pro Ser Ser Ser Asp Leu Asp 
        195                 200                 205


Leu Leu His Lys Ile Val Leu Lys Val Gly Asn Leu Ser Pro His Leu 
    210                 215                 220


Gln Asn Ile Phe Ser Lys Ser Pro Ile Phe Ala Gly Val Val Leu Pro 
225                 230                 235                 240


Gln Val Gln His Pro Lys Asn Ala Arg Lys Lys Tyr Pro Lys Leu Asn 
                245                 250                 255


Gly Leu Leu Ala Asp Ile Val His Ala Cys Leu Gln Ile Asp Pro Ala 
            260                 265                 270


Asp Arg Ile Ser Ser Ser Asp Leu Leu His His Glu Tyr Phe Thr Arg 
        275                 280                 285


Asp Gly Phe Ile Glu Lys Phe Met Pro Glu Leu Lys Ala Lys Leu Leu 
    290                 295                 300


Gln Glu Ala Lys Val Asn Ser Leu Ile Lys Pro Lys Glu Ser Ser Lys 
305                 310                 315                 320


Glu Asn Glu Leu Arg Lys Asp Glu Arg Lys Thr Val Tyr Thr Asn Thr 
                325                 330                 335


Leu Leu Ser Ser Ser Val Leu Gly Lys Glu Ile Glu Lys Glu Lys Lys 
            340                 345                 350


Pro Lys Glu Ile Lys Val Arg Val Ile Lys Val Lys Gly Gly Arg Gly 
        355                 360                 365


Asp Ile Ser Glu Pro Lys Lys Lys Glu Tyr Glu Gly Gly Leu Gly Gln 
    370                 375                 380


Gln Asp Ala Asn Glu Asn Val His Pro Met Ser Pro Asp Thr Lys Leu 
385                 390                 395                 400


Val Thr Ile Glu Pro Pro Asn Pro Ile Asn Pro Ser Thr Asn Cys Asn 
                405                 410                 415


Gly Leu Lys Glu Asn Pro His Cys Gly Gly Ser Val Thr Met Pro Pro 
            420                 425                 430


Ile Asn Leu Thr Asn Ser Asn Leu Met Ala Ala Asn Leu Ser Ser Asn 
        435                 440                 445


Leu Phe His Pro Ser Val Arg 
    450                 455


<210>  2988
<211>  857
<212>  DNA
<213>  Homo sapiens

<400>  2988
gtttagaacg ggtcacgtga gcgcctcgcc tggatgtgag tttcagccag acctgtggat     60

atctgggctt tgggctgtat gatcattgag atggccactg gaaatcccta tcttcctagt    120

agttctgatt tggatttact ccataaaatt gttttgaaag tgggcaattt gtcacctcac    180

ttgcagaata tcttttccaa gagccccatt tttgctgggg tagttcttcc tcaagttcaa    240

caccccaaaa atgcaagaaa aaaatatcca aagcttaatg gattgttggc agatatagtt    300

catgcttgtt tacaaattga tcctgctgac aggatatcat ctagtgatct tttgcatcat    360

gagtatttta ctagagatgg atttattgaa aagaaataga aaaagagaaa aagcccaagg    420

agatcaaagt cagagttatt aaagtcaaag gaggaagagg agatatctca gaaccaaaaa    480

agaaagagta tgaaggtgga cttggtcaac aggatgcaaa tgaaaatgtt catcctatgt    540

ctccagatac aaaacttgta accattgaac caccaaaccc tatcaatccc agcactaact    600

gtaatggctt gaaagaaaat ccacattgcg gaggttctgt gacaatgcca cccatcaatc    660

taactaacag taatttgatg gctgcaaatc tcagttcaaa tctctttcac cccagtgtga    720

ggtgagctgt aacagagaag aaacctaaat aatacaacat tcctgtataa tggtatttca    780

aagaatcgtg ttcatagtgt ctgtatgtaa actgaacttg aagaaaatat attgaaatta    840

aagctgtata atgggcc                                                   857


<210>  2989
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  2989

Met Ile Ile Glu Met Ala Thr Gly Asn Pro Tyr Leu Pro Ser Ser Ser 
1               5                   10                  15


Asp Leu Asp Leu Leu His Lys Ile Val Leu Lys Val Gly Asn Leu Ser 
            20                  25                  30


Pro His Leu Gln Asn Ile Phe Ser Lys Ser Pro Ile Phe Ala Gly Val 
        35                  40                  45


Val Leu Pro Gln Val Gln His Pro Lys Asn Ala Arg Lys Lys Tyr Pro 
    50                  55                  60


Lys Leu Asn Gly Leu Leu Ala Asp Ile Val His Ala Cys Leu Gln Ile 
65                  70                  75                  80


Asp Pro Ala Asp Arg Ile Ser Ser Ser Asp Leu Leu His His Glu Tyr 
                85                  90                  95


Phe Thr Arg Asp Gly Phe Ile Glu Lys Lys 
            100                 105


<210>  2990
<211>  407
<212>  DNA
<213>  Homo sapiens

<400>  2990
agaacgggtc acgtgagcgc ctcgcctgga tgtgagtttc agccagacct gtggatatct     60

gggctttggg ctgtatgatc attgagatgg ccactggaaa tccctatctt cctagtagtt    120

ctgatttgga tttactccat aaaattgttt tgaaagtggg caatttgtca cctcacttgc    180

agaatatctt ttccaagagc cccatttttg ctggggtagt tcttcctcaa gttcaacacc    240

ccaaaaatgc aagaaaaaaa tatccaaagc ttaatggatt gttggcagat atagttcata    300

gacggggttt caccgtgttg gctgtggttg gccaggctgc tcttgaactc ctgagcttag    360

gtgatccgcc cacctcggcc tcccaaagtg ctgggattac aggcatg                  407


<210>  2991
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  2991

Met Ile Ile Glu Met Ala Thr Gly Asn Pro Tyr Leu Pro Ser Ser Ser 
1               5                   10                  15


Asp Leu Asp Leu Leu His Lys Ile Val Leu Lys Val Gly Asn Leu Ser 
            20                  25                  30


Pro His Leu Gln Asn Ile Phe Ser Lys Ser Pro Ile Phe Ala Gly Val 
        35                  40                  45


Val Leu Pro Gln Val Gln His Pro Lys Asn Ala Arg Lys Lys Tyr Pro 
    50                  55                  60


Lys Leu Asn Gly Leu Leu Ala Asp Ile Val His Arg Arg Gly Phe Thr 
65                  70                  75                  80


Val Leu Ala Val Val Gly Gln Ala Ala Leu Glu Leu Leu Ser Leu Gly 
                85                  90                  95


Asp Pro Pro Thr Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly 
            100                 105                 110


<210>  2992
<211>  831
<212>  DNA
<213>  Homo sapiens

<400>  2992
ggcaggagtc gggagagggg ttcgccccaa cacggctcct cggagaagac ggcggggccg     60

tgaaacaaag ctgactggtg ctgccggaga ggaacaagct cccgcaggag ctcactttga    120

ggggacaaga agggggcgcc gcagggtgca ggggcgggcg gataatgtct gatcgcctgg    180

gcgagacgcc gggcagctgg ccgaaatggg cagcagggaa ccctagacca gtcgatcgac    240

accgttttac tttttgtggg gaggggaagc agtatcaaaa tttcttcggg cgccagaacg    300

agcggcaaag cttatgggag tagggccgag gctaggaccc ggcttccgcc agtcccgctg    360

ggcccacagc cggccctctg agggtcacaa aggggaaggt gtctgggatc cacgccctgc    420

agccccgcag ctttgagggg ccgtcatcta ggcgaaggtg aaggccctta ccgcttgaaa    480

tcccgcatga gcctcctccg ggccggggtc gacatgctcc gcagctgccc cgcggtcagt    540

ctgaaaaaaa aaaagtcccg cgcagccccc ccaccccccg gcgcggcggc cgaatcactg    600

tggatcgccg ccgccgccgc cgccgccgcc gccgccgaga ctgacaaaca accctgcaat    660

gacgtctccc tccgccgcct ccggatccct ccgccctccg ccgctaccac agtgatcttg    720

ctctgttgct caggctggaa tgcagtggtg tgatctcgga tcactgcagc cttgacttcc    780

ccagcttaag tgatcctccc acctcagcct cccgagtagc tgagactaca g             831


<210>  2993
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  2993

Met Ser Leu Leu Arg Ala Gly Val Asp Met Leu Arg Ser Cys Pro Ala 
1               5                   10                  15


Val Ser Leu Lys Lys Lys Lys Ser Arg Ala Ala Pro Pro Pro Pro Gly 
            20                  25                  30


Ala Ala Ala Glu Ser Leu Trp Ile Ala Ala Ala Ala Ala Ala Ala Ala 
        35                  40                  45


Ala Ala Glu Thr Asp Lys Gln Pro Cys Asn Asp Val Ser Leu Arg Arg 
    50                  55                  60


Leu Arg Ile Pro Pro Pro Ser Ala Ala Thr Thr Val Ile Leu Leu Cys 
65                  70                  75                  80


Cys Ser Gly Trp Asn Ala Val Val 
                85


<210>  2994
<211>  337
<212>  DNA
<213>  Homo sapiens

<400>  2994
gcgtttagaa cgggtcacgt gagcgcctcg cctggatgta tagagacaac attacccaag     60

aggtcatggc agaatcaaca gcttgttttg ttttctttaa accgggacca aaaataattc    120

ccctctggtt ggttcagtgg cttattaact ctggtacttg gggcaagaag agtgagagga    180

tcgcacgatc ttctaaggca gccttgaata ctgaggccca cacaacaatc tcctgaaatg    240

gttccttgaa gctaccagat agtctttctg ctttgcagtg gggtttctag tattggaaat    300

tctgggcaaa tattaaagga tggtgtatta tgcagtt                             337


<210>  2995
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  2995

Met Tyr Arg Asp Asn Ile Thr Gln Glu Val Met Ala Glu Ser Thr Ala 
1               5                   10                  15


Cys Phe Val Phe Phe Lys Pro Gly Pro Lys Ile Ile Pro Leu Trp Leu 
            20                  25                  30


Val Gln Trp Leu Ile Asn Ser Gly Thr Trp Gly Lys Lys Ser Glu Arg 
        35                  40                  45


Ile Ala Arg Ser Ser Lys Ala Ala Leu Asn Thr Glu Ala His Thr Thr 
    50                  55                  60


Ile Ser 
65


<210>  2996
<211>  4868
<212>  DNA
<213>  Homo sapiens

<400>  2996
gtagatgagt cccccattcg tgagaggggt ccctgggtct agaggcgcga caggcgcccc     60

aggtgcgcga gcgctgcccg tgcccgccgc ggggtccccg cctccgggct ggggcgctgg    120

gacgcctggg tgcccggggc tcgcggccgc ccgccctctt cgctcatcgc cctgcgcgcc    180

ctgccccgca gatgccggcg atcgcggtgt tggcggcggc cgccgcggcg tggtgcttcc    240

tccaagtcga gagccggcac ctggacgcgc tcgccggagg cgcgggcccc aaccacggca    300

atttcctaga caatgaccag tggctgagca ccgtctccca gtacgaccgg gacaagtact    360

ggaaccgctt tcgagacgat gattatttca gaaactggaa tcccaacaag ccctttgacc    420

aagccctgga cccatccaag gacccctgcc tgaaggtaaa atgcagccct cacaaagtgt    480

gtgtgaccca ggactaccag accgccctgt gtgtcagccg caagcacctg ctccccaggc    540

aaaagaaggg gaacgtggcc cagaaacact gggttggacc ttcgaatttg gtcaagtgca    600

agccctgtcc cgtggcacag tcagccatgg tctgcggctc agatggccac tcctacacat    660

ccaagtgcaa attggagttc catgcttgtt ctactggcaa aagcctcgcc accctctgtg    720

atgggccctg tccctgtctc ccagagcctg agccaccaaa gcacaaggca gaaaggagtg    780

cctgcacaga caaggagttg cggaaccttg cctcccggct gaaggattgg tttggagctc    840

tccacgagga tgcgaacaga gtcatcaagc ccaccagctc caacacagcc caaggcaggt    900

ttgacactag catcctgccc atctgcaagg actccctggg ctggatgttc aacaagttgg    960

acatgaacta tgacctcctg cttgaccctt cagagatcaa tgccatctac ctggataagt   1020

acgagccctg tatcaagcct cttttcaact cgtgtgactc cttcaaggat ggcaagcttt   1080

ctaacaatga gtggtgctac tgcttccaga agcctggagg tctcccttgc cagaatgaaa   1140

tgaacagaat tcagaagctg agtaagggga aaagcctgtt gggggccttc atacctcggt   1200

gtaatgagga gggctattac aaagccacac agtgccacgg cagcacgggg cagtgctggt   1260

gtgtggacaa atatgggaat gagttggctg gctccaggaa acagggtgct gtgagctgtg   1320

aagaggagca ggaaacctca ggggattttg gcagtggtgg gtccgtggtc ctgctggatg   1380

acctagaata tgaacgggag ctgggaccaa aggacaaaga ggggaagctg agggtgcaca   1440

cccgagccgt gacagaggat gatgaggatg aggatgatga caaagaggat gaggtcgggt   1500

acatatggta gtgcccacaa gaaagaggac acaagttttg cacaaaattg caagtcactt   1560

cctattcctg catttgtatc taagactcca aggcaccaag gtctcttctc cattgttgct   1620

ctctataccc gacctaaggt ttggaagaca actgcttgtt cccagaggat tctgattttg   1680

catatgtttg tatgggagaa agggtgttgt gttttttttt tgttgttgtt tattttttgg   1740

atagggaagt cattggctta attagagcct ccttcctttc tgtgagattt ttccaacaag   1800

catgtgattt acgtggaatt ctgacagtgc agggagcccc aaccctctta aatgtcaaag   1860

accctttttg attacccaca ctggtggtta ttacagcatg gttcccagcc ttacagtgtc   1920

taagtgcttc tcttgtgtcc tgtagatgtt gtgaaaaaga aaaaaacaaa aaatacacca   1980

cactgtactt tttccccctg cccccgttac tgccggtgat tattattaaa aattagtttt   2040

tttcacatca ttatatctgg cttcctataa acaacagcct taattcagtc aagactccct   2100

ttggggaatt cattttatta aaaattggtg tctggatact tccctgtaca tgcataaata   2160

tgcatgcatg tacagaaaga ctgtatgtgt gtgccttgca cacacaccca tacctctcag   2220

aaaaagtgtt tgggtatctt aaaaactcga aaaacaatga taaatttctc agcttgtcca   2280

gacctggaac aaaatttctg gaataagaaa tttgtattaa agtccttttt tgcactaaca   2340

gttggctctt gtagcctgca ggctgaggaa gtctcttctc tgtgcatcag cagagttact   2400

gaaagcctct gattgagaaa aaacctccgt ctgcctaaat cacttttctc gcagaagcca   2460

tgcgactccc acacgacacg ggcagcttca caagccatct ctttcatttc tgcttgaagc   2520

cccttggctg cagcaatcct gtctgccata ggtttcttcc ttccttacct actcaagggc   2580

tttttctaag gcatgcacac atatctcctg ttctctgaga gtaccatggt gttccttaaa   2640

agaagaaaat ttctaattct gaactcaatg ttttgctttt actccctttc tactgacaaa   2700

tcatgataag ggcacaaaag ctgtacagat tttttttttt aaccactcaa tcccaaatgg   2760

aggcctacaa agaacatcgt aataacacat ggaagcaaac cctgggtttt taagagcaaa   2820

ttctgtcccc ccctcactcc cccaagtgac aagatactaa tgaagaaagt tcttcaccat   2880

agtgtttgtt ttaactaaac tcattggagt ctagttccaa atttggtagg gtcatcatct   2940

ctacattcct taggatttct ctccctatca agctggccca gatacaagta ccaaacagta   3000

gtctctgaag ttcccccatt tccttcagta ccagtctata agctactgtc cgccactgat   3060

tttcatttat cagggtgtcc taatcagaat cagccaccca agcaagcctc tctggcccac   3120

atatctatct cttgccttcc cccatgaact tcagcctgtc cacacaaaag ccacataaac   3180

tcaagcaaga aatatgttca gccaaaacat gattatagtg gcagctgacc aatcccccat   3240

cccaaattga ccatttagat gtaccaactc accttaaatt agcatgttcc aatccagtcg   3300

gcattgcctg aatacagtag catcatacct atagttggtc ttagataaga aatgaactac   3360

ttgatatagc aaagtccttt ggcttcgtaa ataaccctga ggttttgtac ttactttccc   3420

cataggaaga cagaccatag gcaaactctg ttttgggatc tcaactccat cacctttgtt   3480

tcaatatttt ttttctctct tgaacaaaac tgagataatt tagaaaacag gtgcttaatt   3540

gcaataaaat tactatgaag tatattaaaa atcacgacat tgtaaaatct cactttagat   3600

catcaaagaa aaccattgtt actatctcct ttgagcttag gaaaatgtac aagagaacaa   3660

attaaaattg aaaaattgat ttcacttaga aaaacttcta ggaacagggt gaaccactga   3720

ttttaatttg cctaattatc ttatgacaag tatcaaatta agatgacact taaagatcct   3780

tagcattaac ttaatgatgg agaagagtgc tcaatagaca gttcccagta aggtaatgag   3840

atgccatttt cagagacatt ctaagaagat attttgattc attaaaacat taaataaaaa   3900

gccctcctca gattggaacc cccaaatcga tggagccaca ttaataatac ttttcatgcc   3960

tcactttgac atgacagcat tcgatttttt taaagatctt taatactttc catgagtact   4020

aaagattgta atgagttacc ttatccttag aagtagaatg tttgctttct tcttcttgga   4080

aatagtcctc caaaaagtcc acttgtacca gtgacaagaa gtcacttgta tagtgaccaa   4140

gtacacataa aatactgatt ataaaaatat tgtaataaac cacttcctca tttgatacag   4200

gtattaagct gaatcctcac taattcactt ttgaaaagtt cttaatgaac agttttattc   4260

ttattccatg aacagctctt ttaatacaat ttccttggta tccaacttaa atcccagaat   4320

tttgttccac catggttagt tatttgccat atgaatgtat tcttgtttct accaatattc   4380

taggcatgag aataccttaa tactgagttg gagattttgt atctgtttct cctcctttac   4440

gcccattttc ctacccacag cagcaaatga caacgtgtct gtccaggtct gtccccctgc   4500

tcatcccagg atgccactca catttttttc ttcttgttac cttgaccacg ctgtacagta   4560

acatccaaga gcccattcta cagtgggtgg ttttggtctt tttataactt tttctcaaag   4620

tcactgatgt ttgttcctgt taaatgtata gcattgtaat gagagcccat caaatcctga   4680

gtgtcagttt gttgtcccta ttgtagatga aatagtgatg tagcaaaaac ctagtaaatt   4740

ctgaatgctt ttccacgtag acttatctgg aatgtgaaca caactctttg gttaatagta   4800

aatgcttaac tgtagtcctg agtaggtgca tttctgtctg tctcaataaa ttttactttg   4860

tctgcaat                                                            4868


<210>  2997
<211>  439
<212>  PRT
<213>  Homo sapiens

<400>  2997

Met Pro Ala Ile Ala Val Leu Ala Ala Ala Ala Ala Ala Trp Cys Phe 
1               5                   10                  15


Leu Gln Val Glu Ser Arg His Leu Asp Ala Leu Ala Gly Gly Ala Gly 
            20                  25                  30


Pro Asn His Gly Asn Phe Leu Asp Asn Asp Gln Trp Leu Ser Thr Val 
        35                  40                  45


Ser Gln Tyr Asp Arg Asp Lys Tyr Trp Asn Arg Phe Arg Asp Asp Asp 
    50                  55                  60


Tyr Phe Arg Asn Trp Asn Pro Asn Lys Pro Phe Asp Gln Ala Leu Asp 
65                  70                  75                  80


Pro Ser Lys Asp Pro Cys Leu Lys Val Lys Cys Ser Pro His Lys Val 
                85                  90                  95


Cys Val Thr Gln Asp Tyr Gln Thr Ala Leu Cys Val Ser Arg Lys His 
            100                 105                 110


Leu Leu Pro Arg Gln Lys Lys Gly Asn Val Ala Gln Lys His Trp Val 
        115                 120                 125


Gly Pro Ser Asn Leu Val Lys Cys Lys Pro Cys Pro Val Ala Gln Ser 
    130                 135                 140


Ala Met Val Cys Gly Ser Asp Gly His Ser Tyr Thr Ser Lys Cys Lys 
145                 150                 155                 160


Leu Glu Phe His Ala Cys Ser Thr Gly Lys Ser Leu Ala Thr Leu Cys 
                165                 170                 175


Asp Gly Pro Cys Pro Cys Leu Pro Glu Pro Glu Pro Pro Lys His Lys 
            180                 185                 190


Ala Glu Arg Ser Ala Cys Thr Asp Lys Glu Leu Arg Asn Leu Ala Ser 
        195                 200                 205


Arg Leu Lys Asp Trp Phe Gly Ala Leu His Glu Asp Ala Asn Arg Val 
    210                 215                 220


Ile Lys Pro Thr Ser Ser Asn Thr Ala Gln Gly Arg Phe Asp Thr Ser 
225                 230                 235                 240


Ile Leu Pro Ile Cys Lys Asp Ser Leu Gly Trp Met Phe Asn Lys Leu 
                245                 250                 255


Asp Met Asn Tyr Asp Leu Leu Leu Asp Pro Ser Glu Ile Asn Ala Ile 
            260                 265                 270


Tyr Leu Asp Lys Tyr Glu Pro Cys Ile Lys Pro Leu Phe Asn Ser Cys 
        275                 280                 285


Asp Ser Phe Lys Asp Gly Lys Leu Ser Asn Asn Glu Trp Cys Tyr Cys 
    290                 295                 300


Phe Gln Lys Pro Gly Gly Leu Pro Cys Gln Asn Glu Met Asn Arg Ile 
305                 310                 315                 320


Gln Lys Leu Ser Lys Gly Lys Ser Leu Leu Gly Ala Phe Ile Pro Arg 
                325                 330                 335


Cys Asn Glu Glu Gly Tyr Tyr Lys Ala Thr Gln Cys His Gly Ser Thr 
            340                 345                 350


Gly Gln Cys Trp Cys Val Asp Lys Tyr Gly Asn Glu Leu Ala Gly Ser 
        355                 360                 365


Arg Lys Gln Gly Ala Val Ser Cys Glu Glu Glu Gln Glu Thr Ser Gly 
    370                 375                 380


Asp Phe Gly Ser Gly Gly Ser Val Val Leu Leu Asp Asp Leu Glu Tyr 
385                 390                 395                 400


Glu Arg Glu Leu Gly Pro Lys Asp Lys Glu Gly Lys Leu Arg Val His 
                405                 410                 415


Thr Arg Ala Val Thr Glu Asp Asp Glu Asp Glu Asp Asp Asp Lys Glu 
            420                 425                 430


Asp Glu Val Gly Tyr Ile Trp 
        435


<210>  2998
<211>  4841
<212>  DNA
<213>  Homo sapiens

<400>  2998
agcgagcgag cagagcacat cgctgcgggc tcacaaagcg gccagacgct cggcggcggc     60

gtgtggcagg agcgcagggg cgcgagccgg cgatcagcct tcccggcgac cgtgccgcgg    120

gagctcgagc aactcggact aggggacccg ggccggcccc caagatgccg gcgatcgcgg    180

tgttggcggc ggccgccgcg gcgtggtgct tcctccaagt cgagagccgg cacctggacg    240

cgctcgccgg aggcgcgggc cccaaccacg gcaatttcct agacaatgac cagtggctga    300

gcaccgtctc ccagtacgac cgggacaagt actggaaccg ctttcgagac gatgattatt    360

tcagaaactg gaatcccaac aagccctttg accaagccct ggacccatcc aaggacccct    420

gcctgaaggt aaaatgcagc cctcacaaag tgtgtgtgac ccaggactac cagaccgccc    480

tgtgtgtcag ccgcaagcac ctgctcccca ggcaaaagaa ggggaacgtg gcccagaaac    540

actgggttgg accttcgaat ttggtcaagt gcaagccctg tcccgtggca cagtcagcca    600

tggtctgcgg ctcagatggc cactcctaca catccaagtg caaattggag ttccatgctt    660

gttctactgg caaaagcctc gccaccctct gtgatgggcc ctgtccctgt ctcccagagc    720

ctgagccacc aaagcacaag gcagaaagga gtgcctgcac agacaaggag ttgcggaacc    780

ttgcctcccg gctgaaggat tggtttggag ctctccacga ggatgcgaac agagtcatca    840

agcccaccag ctccaacaca gcccaaggca ggtttgacac tagcatcctg cccatctgca    900

aggactccct gggctggatg ttcaacaagt tggacatgaa ctatgacctc ctgcttgacc    960

cttcagagat caatgccatc tacctggata agtacgagcc ctgtatcaag cctcttttca   1020

actcgtgtga ctccttcaag gatggcaagc tttctaacaa tgagtggtgc tactgcttcc   1080

agaagcctgg aggtctccct tgccagaatg aaatgaacag aattcagaag ctgagtaagg   1140

ggaaaagcct gttgggggcc ttcatacctc ggtgtaatga ggagggctat tacaaagcca   1200

cacagtgcca cggcagcacg gggcagtgct ggtgtgtgga caaatatggg aatgagttgg   1260

ctggctccag gaaacagggt gctgtgagct gtgaagagga gcaggaaacc tcaggggatt   1320

ttggcagtgg tgggtccgtg gtcctgctgg atgacctaga atatgaacgg gagctgggac   1380

caaaggacaa agaggggaag ctgagggtgc acacccgagc cgtgacagag gatgatgagg   1440

atgaggatga tgacaaagag gatgaggtcg ggtacatatg gtagtgccca caagaaagag   1500

gacacaagtt ttgcacaaaa ttgcaagtca cttcctattc ctgcatttgt atctaagact   1560

ccaaggcacc aaggtctctt ctccattgtt gctctctata cccgacctaa ggtttggaag   1620

acaactgctt gttcccagag gattctgatt ttgcatatgt ttgtatggga gaaagggtgt   1680

tgtgtttttt ttttgttgtt gtttattttt tggataggga agtcattggc ttaattagag   1740

cctccttcct ttctgtgaga tttttccaac aagcatgtga tttacgtgga attctgacag   1800

tgcagggagc cccaaccctc ttaaatgtca aagacccttt ttgattaccc acactggtgg   1860

ttattacagc atggttccca gccttacagt gtctaagtgc ttctcttgtg tcctgtagat   1920

gttgtgaaaa agaaaaaaac aaaaaataca ccacactgta ctttttcccc ctgcccccgt   1980

tactgccggt gattattatt aaaaattagt ttttttcaca tcattatatc tggcttccta   2040

taaacaacag ccttaattca gtcaagactc cctttgggga attcatttta ttaaaaattg   2100

gtgtctggat acttccctgt acatgcataa atatgcatgc atgtacagaa agactgtatg   2160

tgtgtgcctt gcacacacac ccatacctct cagaaaaagt gtttgggtat cttaaaaact   2220

cgaaaaacaa tgataaattt ctcagcttgt ccagacctgg aacaaaattt ctggaataag   2280

aaatttgtat taaagtcctt ttttgcacta acagttggct cttgtagcct gcaggctgag   2340

gaagtctctt ctctgtgcat cagcagagtt actgaaagcc tctgattgag aaaaaacctc   2400

cgtctgccta aatcactttt ctcgcagaag ccatgcgact cccacacgac acgggcagct   2460

tcacaagcca tctctttcat ttctgcttga agccccttgg ctgcagcaat cctgtctgcc   2520

ataggtttct tccttcctta cctactcaag ggctttttct aaggcatgca cacatatctc   2580

ctgttctctg agagtaccat ggtgttcctt aaaagaagaa aatttctaat tctgaactca   2640

atgttttgct tttactccct ttctactgac aaatcatgat aagggcacaa aagctgtaca   2700

gatttttttt tttaaccact caatcccaaa tggaggccta caaagaacat cgtaataaca   2760

catggaagca aaccctgggt ttttaagagc aaattctgtc cccccctcac tcccccaagt   2820

gacaagatac taatgaagaa agttcttcac catagtgttt gttttaacta aactcattgg   2880

agtctagttc caaatttggt agggtcatca tctctacatt ccttaggatt tctctcccta   2940

tcaagctggc ccagatacaa gtaccaaaca gtagtctctg aagttccccc atttccttca   3000

gtaccagtct ataagctact gtccgccact gattttcatt tatcagggtg tcctaatcag   3060

aatcagccac ccaagcaagc ctctctggcc cacatatcta tctcttgcct tcccccatga   3120

acttcagcct gtccacacaa aagccacata aactcaagca agaaatatgt tcagccaaaa   3180

catgattata gtggcagctg accaatcccc catcccaaat tgaccattta gatgtaccaa   3240

ctcaccttaa attagcatgt tccaatccag tcggcattgc ctgaatacag tagcatcata   3300

cctatagttg gtcttagata agaaatgaac tacttgatat agcaaagtcc tttggcttcg   3360

taaataaccc tgaggttttg tacttacttt ccccatagga agacagacca taggcaaact   3420

ctgttttggg atctcaactc catcaccttt gtttcaatat tttttttctc tcttgaacaa   3480

aactgagata atttagaaaa caggtgctta attgcaataa aattactatg aagtatatta   3540

aaaatcacga cattgtaaaa tctcacttta gatcatcaaa gaaaaccatt gttactatct   3600

cctttgagct taggaaaatg tacaagagaa caaattaaaa ttgaaaaatt gatttcactt   3660

agaaaaactt ctaggaacag ggtgaaccac tgattttaat ttgcctaatt atcttatgac   3720

aagtatcaaa ttaagatgac acttaaagat ccttagcatt aacttaatga tggagaagag   3780

tgctcaatag acagttccca gtaaggtaat gagatgccat tttcagagac attctaagaa   3840

gatattttga ttcattaaaa cattaaataa aaagccctcc tcagattgga acccccaaat   3900

cgatggagcc acattaataa tacttttcat gcctcacttt gacatgacag cattcgattt   3960

ttttaaagat ctttaatact ttccatgagt actaaagatt gtaatgagtt accttatcct   4020

tagaagtaga atgtttgctt tcttcttctt ggaaatagtc ctccaaaaag tccacttgta   4080

ccagtgacaa gaagtcactt gtatagtgac caagtacaca taaaatactg attataaaaa   4140

tattgtaata aaccacttcc tcatttgata caggtattaa gctgaatcct cactaattca   4200

cttttgaaaa gttcttaatg aacagtttta ttcttattcc atgaacagct cttttaatac   4260

aatttccttg gtatccaact taaatcccag aattttgttc caccatggtt agttatttgc   4320

catatgaatg tattcttgtt tctaccaata ttctaggcat gagaatacct taatactgag   4380

ttggagattt tgtatctgtt tctcctcctt tacgcccatt ttcctaccca cagcagcaaa   4440

tgacaacgtg tctgtccagg tctgtccccc tgctcatccc aggatgccac tcacattttt   4500

ttcttcttgt taccttgacc acgctgtaca gtaacatcca agagcccatt ctacagtggg   4560

tggttttggt ctttttataa ctttttctca aagtcactga tgtttgttcc tgttaaatgt   4620

atagcattgt aatgagagcc catcaaatcc tgagtgtcag tttgttgtcc ctattgtaga   4680

tgaaatagtg atgtagcaaa aacctagtaa attctgaatg cttttccacg tagacttatc   4740

tggaatgtga acacaactct ttggttaata gtaaatgctt aactgtagtc ctgagtaggt   4800

gcatttctgt ctgtctcaat aaattttact ttgtctgcaa t                       4841


<210>  2999
<211>  439
<212>  PRT
<213>  Homo sapiens

<400>  2999

Met Pro Ala Ile Ala Val Leu Ala Ala Ala Ala Ala Ala Trp Cys Phe 
1               5                   10                  15


Leu Gln Val Glu Ser Arg His Leu Asp Ala Leu Ala Gly Gly Ala Gly 
            20                  25                  30


Pro Asn His Gly Asn Phe Leu Asp Asn Asp Gln Trp Leu Ser Thr Val 
        35                  40                  45


Ser Gln Tyr Asp Arg Asp Lys Tyr Trp Asn Arg Phe Arg Asp Asp Asp 
    50                  55                  60


Tyr Phe Arg Asn Trp Asn Pro Asn Lys Pro Phe Asp Gln Ala Leu Asp 
65                  70                  75                  80


Pro Ser Lys Asp Pro Cys Leu Lys Val Lys Cys Ser Pro His Lys Val 
                85                  90                  95


Cys Val Thr Gln Asp Tyr Gln Thr Ala Leu Cys Val Ser Arg Lys His 
            100                 105                 110


Leu Leu Pro Arg Gln Lys Lys Gly Asn Val Ala Gln Lys His Trp Val 
        115                 120                 125


Gly Pro Ser Asn Leu Val Lys Cys Lys Pro Cys Pro Val Ala Gln Ser 
    130                 135                 140


Ala Met Val Cys Gly Ser Asp Gly His Ser Tyr Thr Ser Lys Cys Lys 
145                 150                 155                 160


Leu Glu Phe His Ala Cys Ser Thr Gly Lys Ser Leu Ala Thr Leu Cys 
                165                 170                 175


Asp Gly Pro Cys Pro Cys Leu Pro Glu Pro Glu Pro Pro Lys His Lys 
            180                 185                 190


Ala Glu Arg Ser Ala Cys Thr Asp Lys Glu Leu Arg Asn Leu Ala Ser 
        195                 200                 205


Arg Leu Lys Asp Trp Phe Gly Ala Leu His Glu Asp Ala Asn Arg Val 
    210                 215                 220


Ile Lys Pro Thr Ser Ser Asn Thr Ala Gln Gly Arg Phe Asp Thr Ser 
225                 230                 235                 240


Ile Leu Pro Ile Cys Lys Asp Ser Leu Gly Trp Met Phe Asn Lys Leu 
                245                 250                 255


Asp Met Asn Tyr Asp Leu Leu Leu Asp Pro Ser Glu Ile Asn Ala Ile 
            260                 265                 270


Tyr Leu Asp Lys Tyr Glu Pro Cys Ile Lys Pro Leu Phe Asn Ser Cys 
        275                 280                 285


Asp Ser Phe Lys Asp Gly Lys Leu Ser Asn Asn Glu Trp Cys Tyr Cys 
    290                 295                 300


Phe Gln Lys Pro Gly Gly Leu Pro Cys Gln Asn Glu Met Asn Arg Ile 
305                 310                 315                 320


Gln Lys Leu Ser Lys Gly Lys Ser Leu Leu Gly Ala Phe Ile Pro Arg 
                325                 330                 335


Cys Asn Glu Glu Gly Tyr Tyr Lys Ala Thr Gln Cys His Gly Ser Thr 
            340                 345                 350


Gly Gln Cys Trp Cys Val Asp Lys Tyr Gly Asn Glu Leu Ala Gly Ser 
        355                 360                 365


Arg Lys Gln Gly Ala Val Ser Cys Glu Glu Glu Gln Glu Thr Ser Gly 
    370                 375                 380


Asp Phe Gly Ser Gly Gly Ser Val Val Leu Leu Asp Asp Leu Glu Tyr 
385                 390                 395                 400


Glu Arg Glu Leu Gly Pro Lys Asp Lys Glu Gly Lys Leu Arg Val His 
                405                 410                 415


Thr Arg Ala Val Thr Glu Asp Asp Glu Asp Glu Asp Asp Asp Lys Glu 
            420                 425                 430


Asp Glu Val Gly Tyr Ile Trp 
        435


<210>  3000
<211>  4850
<212>  DNA
<213>  Homo sapiens

<400>  3000
agcgagcgag cagagcacat cgctgcgggc tcacaaagcg gccagacgct cggcggcggc     60

gtgtggcagg agcgcagggg cgcgagccgg cgatcagcct tcccggcgac cgtgccgcgg    120

gagctcgagc aactcggact aggggacccg ggccggcccc caagatgccg gcgatcgcgg    180

tgttggcggc ggccgccgcg gcgtggtgct tcctccaagt cgagagccgg cacctggacg    240

cgctcgccgg aggcgcgggc cccaaccacg gcaatttcct agacaatgac cagtggctga    300

gcaccgtctc ccagtacgac cgggacaagt actggaaccg ctttcgagac gaagttgagg    360

atgattattt cagaaactgg aatcccaaca agccctttga ccaagccctg gacccatcca    420

aggacccctg cctgaaggta aaatgcagcc ctcacaaagt gtgtgtgacc caggactacc    480

agaccgccct gtgtgtcagc cgcaagcacc tgctccccag gcaaaagaag gggaacgtgg    540

cccagaaaca ctgggttgga ccttcgaatt tggtcaagtg caagccctgt cccgtggcac    600

agtcagccat ggtctgcggc tcagatggcc actcctacac atccaagtgc aaattggagt    660

tccatgcttg ttctactggc aaaagcctcg ccaccctctg tgatgggccc tgtccctgtc    720

tcccagagcc tgagccacca aagcacaagg cagaaaggag tgcctgcaca gacaaggagt    780

tgcggaacct tgcctcccgg ctgaaggatt ggtttggagc tctccacgag gatgcgaaca    840

gagtcatcaa gcccaccagc tccaacacag cccaaggcag gtttgacact agcatcctgc    900

ccatctgcaa ggactccctg ggctggatgt tcaacaagtt ggacatgaac tatgacctcc    960

tgcttgaccc ttcagagatc aatgccatct acctggataa gtacgagccc tgtatcaagc   1020

ctcttttcaa ctcgtgtgac tccttcaagg atggcaagct ttctaacaat gagtggtgct   1080

actgcttcca gaagcctgga ggtctccctt gccagaatga aatgaacaga attcagaagc   1140

tgagtaaggg gaaaagcctg ttgggggcct tcatacctcg gtgtaatgag gagggctatt   1200

acaaagccac acagtgccac ggcagcacgg ggcagtgctg gtgtgtggac aaatatggga   1260

atgagttggc tggctccagg aaacagggtg ctgtgagctg tgaagaggag caggaaacct   1320

caggggattt tggcagtggt gggtccgtgg tcctgctgga tgacctagaa tatgaacggg   1380

agctgggacc aaaggacaaa gaggggaagc tgagggtgca cacccgagcc gtgacagagg   1440

atgatgagga tgaggatgat gacaaagagg atgaggtcgg gtacatatgg tagtgcccac   1500

aagaaagagg acacaagttt tgcacaaaat tgcaagtcac ttcctattcc tgcatttgta   1560

tctaagactc caaggcacca aggtctcttc tccattgttg ctctctatac ccgacctaag   1620

gtttggaaga caactgcttg ttcccagagg attctgattt tgcatatgtt tgtatgggag   1680

aaagggtgtt gtgttttttt tttgttgttg tttatttttt ggatagggaa gtcattggct   1740

taattagagc ctccttcctt tctgtgagat ttttccaaca agcatgtgat ttacgtggaa   1800

ttctgacagt gcagggagcc ccaaccctct taaatgtcaa agaccctttt tgattaccca   1860

cactggtggt tattacagca tggttcccag ccttacagtg tctaagtgct tctcttgtgt   1920

cctgtagatg ttgtgaaaaa gaaaaaaaca aaaaatacac cacactgtac tttttccccc   1980

tgcccccgtt actgccggtg attattatta aaaattagtt tttttcacat cattatatct   2040

ggcttcctat aaacaacagc cttaattcag tcaagactcc ctttggggaa ttcattttat   2100

taaaaattgg tgtctggata cttccctgta catgcataaa tatgcatgca tgtacagaaa   2160

gactgtatgt gtgtgccttg cacacacacc catacctctc agaaaaagtg tttgggtatc   2220

ttaaaaactc gaaaaacaat gataaatttc tcagcttgtc cagacctgga acaaaatttc   2280

tggaataaga aatttgtatt aaagtccttt tttgcactaa cagttggctc ttgtagcctg   2340

caggctgagg aagtctcttc tctgtgcatc agcagagtta ctgaaagcct ctgattgaga   2400

aaaaacctcc gtctgcctaa atcacttttc tcgcagaagc catgcgactc ccacacgaca   2460

cgggcagctt cacaagccat ctctttcatt tctgcttgaa gccccttggc tgcagcaatc   2520

ctgtctgcca taggtttctt ccttccttac ctactcaagg gctttttcta aggcatgcac   2580

acatatctcc tgttctctga gagtaccatg gtgttcctta aaagaagaaa atttctaatt   2640

ctgaactcaa tgttttgctt ttactccctt tctactgaca aatcatgata agggcacaaa   2700

agctgtacag attttttttt ttaaccactc aatcccaaat ggaggcctac aaagaacatc   2760

gtaataacac atggaagcaa accctgggtt tttaagagca aattctgtcc ccccctcact   2820

cccccaagtg acaagatact aatgaagaaa gttcttcacc atagtgtttg ttttaactaa   2880

actcattgga gtctagttcc aaatttggta gggtcatcat ctctacattc cttaggattt   2940

ctctccctat caagctggcc cagatacaag taccaaacag tagtctctga agttccccca   3000

tttccttcag taccagtcta taagctactg tccgccactg attttcattt atcagggtgt   3060

cctaatcaga atcagccacc caagcaagcc tctctggccc acatatctat ctcttgcctt   3120

cccccatgaa cttcagcctg tccacacaaa agccacataa actcaagcaa gaaatatgtt   3180

cagccaaaac atgattatag tggcagctga ccaatccccc atcccaaatt gaccatttag   3240

atgtaccaac tcaccttaaa ttagcatgtt ccaatccagt cggcattgcc tgaatacagt   3300

agcatcatac ctatagttgg tcttagataa gaaatgaact acttgatata gcaaagtcct   3360

ttggcttcgt aaataaccct gaggttttgt acttactttc cccataggaa gacagaccat   3420

aggcaaactc tgttttggga tctcaactcc atcacctttg tttcaatatt ttttttctct   3480

cttgaacaaa actgagataa tttagaaaac aggtgcttaa ttgcaataaa attactatga   3540

agtatattaa aaatcacgac attgtaaaat ctcactttag atcatcaaag aaaaccattg   3600

ttactatctc ctttgagctt aggaaaatgt acaagagaac aaattaaaat tgaaaaattg   3660

atttcactta gaaaaacttc taggaacagg gtgaaccact gattttaatt tgcctaatta   3720

tcttatgaca agtatcaaat taagatgaca cttaaagatc cttagcatta acttaatgat   3780

ggagaagagt gctcaataga cagttcccag taaggtaatg agatgccatt ttcagagaca   3840

ttctaagaag atattttgat tcattaaaac attaaataaa aagccctcct cagattggaa   3900

cccccaaatc gatggagcca cattaataat acttttcatg cctcactttg acatgacagc   3960

attcgatttt tttaaagatc tttaatactt tccatgagta ctaaagattg taatgagtta   4020

ccttatcctt agaagtagaa tgtttgcttt cttcttcttg gaaatagtcc tccaaaaagt   4080

ccacttgtac cagtgacaag aagtcacttg tatagtgacc aagtacacat aaaatactga   4140

ttataaaaat attgtaataa accacttcct catttgatac aggtattaag ctgaatcctc   4200

actaattcac ttttgaaaag ttcttaatga acagttttat tcttattcca tgaacagctc   4260

ttttaataca atttccttgg tatccaactt aaatcccaga attttgttcc accatggtta   4320

gttatttgcc atatgaatgt attcttgttt ctaccaatat tctaggcatg agaatacctt   4380

aatactgagt tggagatttt gtatctgttt ctcctccttt acgcccattt tcctacccac   4440

agcagcaaat gacaacgtgt ctgtccaggt ctgtccccct gctcatccca ggatgccact   4500

cacatttttt tcttcttgtt accttgacca cgctgtacag taacatccaa gagcccattc   4560

tacagtgggt ggttttggtc tttttataac tttttctcaa agtcactgat gtttgttcct   4620

gttaaatgta tagcattgta atgagagccc atcaaatcct gagtgtcagt ttgttgtccc   4680

tattgtagat gaaatagtga tgtagcaaaa acctagtaaa ttctgaatgc ttttccacgt   4740

agacttatct ggaatgtgaa cacaactctt tggttaatag taaatgctta actgtagtcc   4800

tgagtaggtg catttctgtc tgtctcaata aattttactt tgtctgcaat              4850


<210>  3001
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  3001

Met Pro Ala Ile Ala Val Leu Ala Ala Ala Ala Ala Ala Trp Cys Phe 
1               5                   10                  15


Leu Gln Val Glu Ser Arg His Leu Asp Ala Leu Ala Gly Gly Ala Gly 
            20                  25                  30


Pro Asn His Gly Asn Phe Leu Asp Asn Asp Gln Trp Leu Ser Thr Val 
        35                  40                  45


Ser Gln Tyr Asp Arg Asp Lys Tyr Trp Asn Arg Phe Arg Asp Glu Val 
    50                  55                  60


Glu Asp Asp Tyr Phe Arg Asn Trp Asn Pro Asn Lys Pro Phe Asp Gln 
65                  70                  75                  80


Ala Leu Asp Pro Ser Lys Asp Pro Cys Leu Lys Val Lys Cys Ser Pro 
                85                  90                  95


His Lys Val Cys Val Thr Gln Asp Tyr Gln Thr Ala Leu Cys Val Ser 
            100                 105                 110


Arg Lys His Leu Leu Pro Arg Gln Lys Lys Gly Asn Val Ala Gln Lys 
        115                 120                 125


His Trp Val Gly Pro Ser Asn Leu Val Lys Cys Lys Pro Cys Pro Val 
    130                 135                 140


Ala Gln Ser Ala Met Val Cys Gly Ser Asp Gly His Ser Tyr Thr Ser 
145                 150                 155                 160


Lys Cys Lys Leu Glu Phe His Ala Cys Ser Thr Gly Lys Ser Leu Ala 
                165                 170                 175


Thr Leu Cys Asp Gly Pro Cys Pro Cys Leu Pro Glu Pro Glu Pro Pro 
            180                 185                 190


Lys His Lys Ala Glu Arg Ser Ala Cys Thr Asp Lys Glu Leu Arg Asn 
        195                 200                 205


Leu Ala Ser Arg Leu Lys Asp Trp Phe Gly Ala Leu His Glu Asp Ala 
    210                 215                 220


Asn Arg Val Ile Lys Pro Thr Ser Ser Asn Thr Ala Gln Gly Arg Phe 
225                 230                 235                 240


Asp Thr Ser Ile Leu Pro Ile Cys Lys Asp Ser Leu Gly Trp Met Phe 
                245                 250                 255


Asn Lys Leu Asp Met Asn Tyr Asp Leu Leu Leu Asp Pro Ser Glu Ile 
            260                 265                 270


Asn Ala Ile Tyr Leu Asp Lys Tyr Glu Pro Cys Ile Lys Pro Leu Phe 
        275                 280                 285


Asn Ser Cys Asp Ser Phe Lys Asp Gly Lys Leu Ser Asn Asn Glu Trp 
    290                 295                 300


Cys Tyr Cys Phe Gln Lys Pro Gly Gly Leu Pro Cys Gln Asn Glu Met 
305                 310                 315                 320


Asn Arg Ile Gln Lys Leu Ser Lys Gly Lys Ser Leu Leu Gly Ala Phe 
                325                 330                 335


Ile Pro Arg Cys Asn Glu Glu Gly Tyr Tyr Lys Ala Thr Gln Cys His 
            340                 345                 350


Gly Ser Thr Gly Gln Cys Trp Cys Val Asp Lys Tyr Gly Asn Glu Leu 
        355                 360                 365


Ala Gly Ser Arg Lys Gln Gly Ala Val Ser Cys Glu Glu Glu Gln Glu 
    370                 375                 380


Thr Ser Gly Asp Phe Gly Ser Gly Gly Ser Val Val Leu Leu Asp Asp 
385                 390                 395                 400


Leu Glu Tyr Glu Arg Glu Leu Gly Pro Lys Asp Lys Glu Gly Lys Leu 
                405                 410                 415


Arg Val His Thr Arg Ala Val Thr Glu Asp Asp Glu Asp Glu Asp Asp 
            420                 425                 430


Asp Lys Glu Asp Glu Val Gly Tyr Ile Trp 
        435                 440


<210>  3002
<211>  2052
<212>  DNA
<213>  Homo sapiens

<400>  3002
gtagatgagt cccccattcg tgagaggggt ccctgggtct agaggcgcga caggcgcccc     60

aggtgcgcga gcgctgcccg tgcccgccgc ggggtccccg cctccgggct ggggcgctgg    120

gacgcctggg tgcccggggc tcgcggccgc ccgccctctt cgctcatcgc cctgcgcgcc    180

ctgccccgca gatgccggcg atcgcggtgt tggcggcggc cgccgcggcg tggtgcttcc    240

tccaagtcga gagccggcac ctggacgcgc tcgccggagg cgcgggcccc aaccacggca    300

atttcctaga caatgaccag tggctgagca ccgtctccca gtacgaccgg gacaagtact    360

ggaaccgctt tcgagacgat gattatttca gaaactggaa tcccaacaag ccctttgacc    420

aagccctgga cccatccaag gacccctgcc tgaaggtaaa atgcagccct cacaaagtgt    480

gtgtgaccca ggactaccag accgccctgt gtgtcagccg caagcacctg ctccccaggc    540

aaaagaaggg gaacgtggcc cagaaacact gggttggacc ttcgaatttg gtcaagtgca    600

agccctgtcc cgtggcacag tcagccatgg tctgcggctc agatggccac tcctacacat    660

ccaagtgcaa attggagttc catgcttgtt ctactggcaa aagcctcgcc accctctgtg    720

atgggccctg tccctgtctc ccagagcctg agccaccaaa gcacaaggca gaaaggagtg    780

cctgcacaga caaggagttg cggaaccttg cctcccggct gaaggattgg tttggagctc    840

tccacgagga tgcgaacaga gtcatcaagc ccaccagctc caacacagcc caaggcaggt    900

ttgacactag catcctgccc atctgcaagg actccctggg ctggatgttc aacaagttgg    960

acatgaacta tgacctcctg cttgaccctt cagagatcaa tgccatctac ctggataagt   1020

acgagccctg tatcaagcct cttttcaact cgtgtgactc cttcaaggat ggcaagcttt   1080

ctaacaatga gtggtgctac tgcttccaga agcctggagg tctcccttgc cagaatgaaa   1140

tgaacagaat tcagaagctg agtaagggga aaagcctgtt gggggccttc atacctcggt   1200

gtaatgagga gggctattac aaagccacac agtgccacgg cagcacgggg cagtgctggt   1260

gtgtggacaa atatgggaat gagttggctg gctccaggaa acagggtgct gtgagctgtg   1320

aagaggagca ggaaacctca ggggattttg gcagtggtgg gtccgtggtc ctgctggatg   1380

acctagaata tgaacgggag ctgggaccaa aggacaaaga ggggaagctg agggtgcaca   1440

cccgagccgt gacagaggat gatgaggatg aggatgatga caaagaggat gaggtcgggt   1500

acatatggta gtgcccacaa gaaagaggac acaagttttg cacaaaattg caagtcactt   1560

cctattcctg catttgtatc taagactcca aggcaccaag gtctcttctc cattgttgct   1620

ctctataccc gacctaaggt ttggaagaca actgcttgtt cccagaggat tctgattttg   1680

catatgtttg tatgggagaa agggtgttgt gttttttttt tgttgttgtt tattttttgg   1740

atagggaagt cattggctta attagagcct ccttcctttc tgtgagattt ttccaacaag   1800

catgtgattt acgtggaatt ctgacagtgc agggagcccc aaccctctta aatgtcaaag   1860

accctttttg attacccaca ctggtggtta ttacagcatg gttcccagcc ttacagtgtc   1920

taagtgcttc tcttgtgtcc tgtagatgtt gtgaaaaaga aaaaaacaaa aaatacacca   1980

cactgtactt tttccccctg cccccgttac tgccggtgat tattattaaa aattagtttt   2040

tttcacatca tt                                                       2052


<210>  3003
<211>  439
<212>  PRT
<213>  Homo sapiens

<400>  3003

Met Pro Ala Ile Ala Val Leu Ala Ala Ala Ala Ala Ala Trp Cys Phe 
1               5                   10                  15


Leu Gln Val Glu Ser Arg His Leu Asp Ala Leu Ala Gly Gly Ala Gly 
            20                  25                  30


Pro Asn His Gly Asn Phe Leu Asp Asn Asp Gln Trp Leu Ser Thr Val 
        35                  40                  45


Ser Gln Tyr Asp Arg Asp Lys Tyr Trp Asn Arg Phe Arg Asp Asp Asp 
    50                  55                  60


Tyr Phe Arg Asn Trp Asn Pro Asn Lys Pro Phe Asp Gln Ala Leu Asp 
65                  70                  75                  80


Pro Ser Lys Asp Pro Cys Leu Lys Val Lys Cys Ser Pro His Lys Val 
                85                  90                  95


Cys Val Thr Gln Asp Tyr Gln Thr Ala Leu Cys Val Ser Arg Lys His 
            100                 105                 110


Leu Leu Pro Arg Gln Lys Lys Gly Asn Val Ala Gln Lys His Trp Val 
        115                 120                 125


Gly Pro Ser Asn Leu Val Lys Cys Lys Pro Cys Pro Val Ala Gln Ser 
    130                 135                 140


Ala Met Val Cys Gly Ser Asp Gly His Ser Tyr Thr Ser Lys Cys Lys 
145                 150                 155                 160


Leu Glu Phe His Ala Cys Ser Thr Gly Lys Ser Leu Ala Thr Leu Cys 
                165                 170                 175


Asp Gly Pro Cys Pro Cys Leu Pro Glu Pro Glu Pro Pro Lys His Lys 
            180                 185                 190


Ala Glu Arg Ser Ala Cys Thr Asp Lys Glu Leu Arg Asn Leu Ala Ser 
        195                 200                 205


Arg Leu Lys Asp Trp Phe Gly Ala Leu His Glu Asp Ala Asn Arg Val 
    210                 215                 220


Ile Lys Pro Thr Ser Ser Asn Thr Ala Gln Gly Arg Phe Asp Thr Ser 
225                 230                 235                 240


Ile Leu Pro Ile Cys Lys Asp Ser Leu Gly Trp Met Phe Asn Lys Leu 
                245                 250                 255


Asp Met Asn Tyr Asp Leu Leu Leu Asp Pro Ser Glu Ile Asn Ala Ile 
            260                 265                 270


Tyr Leu Asp Lys Tyr Glu Pro Cys Ile Lys Pro Leu Phe Asn Ser Cys 
        275                 280                 285


Asp Ser Phe Lys Asp Gly Lys Leu Ser Asn Asn Glu Trp Cys Tyr Cys 
    290                 295                 300


Phe Gln Lys Pro Gly Gly Leu Pro Cys Gln Asn Glu Met Asn Arg Ile 
305                 310                 315                 320


Gln Lys Leu Ser Lys Gly Lys Ser Leu Leu Gly Ala Phe Ile Pro Arg 
                325                 330                 335


Cys Asn Glu Glu Gly Tyr Tyr Lys Ala Thr Gln Cys His Gly Ser Thr 
            340                 345                 350


Gly Gln Cys Trp Cys Val Asp Lys Tyr Gly Asn Glu Leu Ala Gly Ser 
        355                 360                 365


Arg Lys Gln Gly Ala Val Ser Cys Glu Glu Glu Gln Glu Thr Ser Gly 
    370                 375                 380


Asp Phe Gly Ser Gly Gly Ser Val Val Leu Leu Asp Asp Leu Glu Tyr 
385                 390                 395                 400


Glu Arg Glu Leu Gly Pro Lys Asp Lys Glu Gly Lys Leu Arg Val His 
                405                 410                 415


Thr Arg Ala Val Thr Glu Asp Asp Glu Asp Glu Asp Asp Asp Lys Glu 
            420                 425                 430


Asp Glu Val Gly Tyr Ile Trp 
        435


<210>  3004
<211>  2034
<212>  DNA
<213>  Homo sapiens

<400>  3004
agcgagcgag cagagcacat cgctgcgggc tcacaaagcg gccagacgct cggcggcggc     60

gtgtggcagg agcgcagggg cgcgagccgg cgatcagcct tcccggcgac cgtgccgcgg    120

gagctcgagc aactcggact aggggacccg ggccggcccc caagatgccg gcgatcgcgg    180

tgttggcggc ggccgccgcg gcgtggtgct tcctccaagt cgagagccgg cacctggacg    240

cgctcgccgg aggcgcgggc cccaaccacg gcaatttcct agacaatgac cagtggctga    300

gcaccgtctc ccagtacgac cgggacaagt actggaaccg ctttcgagac gaagttgagg    360

atgattattt cagaaactgg aatcccaaca agccctttga ccaagccctg gacccatcca    420

aggacccctg cctgaaggta aaatgcagcc ctcacaaagt gtgtgtgacc caggactacc    480

agaccgccct gtgtgtcagc cgcaagcacc tgctccccag gcaaaagaag gggaacgtgg    540

cccagaaaca ctgggttgga ccttcgaatt tggtcaagtg caagccctgt cccgtggcac    600

agtcagccat ggtctgcggc tcagatggcc actcctacac atccaagtgc aaattggagt    660

tccatgcttg ttctactggc aaaagcctcg ccaccctctg tgatgggccc tgtccctgtc    720

tcccagagcc tgagccacca aagcacaagg cagaaaggag tgcctgcaca gacaaggagt    780

tgcggaacct tgcctcccgg ctgaaggatt ggtttggagc tctccacgag gatgcgaaca    840

gagtcatcaa gcccaccagc tccaacacag cccaaggcag gtttgacact agcatcctgc    900

ccatctgcaa ggactccctg ggctggatgt tcaacaagtt ggacatgaac tatgacctcc    960

tgcttgaccc ttcagagatc aatgccatct acctggataa gtacgagccc tgtatcaagc   1020

ctcttttcaa ctcgtgtgac tccttcaagg atggcaagct ttctaacaat gagtggtgct   1080

actgcttcca gaagcctgga ggtctccctt gccagaatga aatgaacaga attcagaagc   1140

tgagtaaggg gaaaagcctg ttgggggcct tcatacctcg gtgtaatgag gagggctatt   1200

acaaagccac acagtgccac ggcagcacgg ggcagtgctg gtgtgtggac aaatatggga   1260

atgagttggc tggctccagg aaacagggtg ctgtgagctg tgaagaggag caggaaacct   1320

caggggattt tggcagtggt gggtccgtgg tcctgctgga tgacctagaa tatgaacggg   1380

agctgggacc aaaggacaaa gaggggaagc tgagggtgca cacccgagcc gtgacagagg   1440

atgatgagga tgaggatgat gacaaagagg atgaggtcgg gtacatatgg tagtgcccac   1500

aagaaagagg acacaagttt tgcacaaaat tgcaagtcac ttcctattcc tgcatttgta   1560

tctaagactc caaggcacca aggtctcttc tccattgttg ctctctatac ccgacctaag   1620

gtttggaaga caactgcttg ttcccagagg attctgattt tgcatatgtt tgtatgggag   1680

aaagggtgtt gtgttttttt tttgttgttg tttatttttt ggatagggaa gtcattggct   1740

taattagagc ctccttcctt tctgtgagat ttttccaaca agcatgtgat ttacgtggaa   1800

ttctgacagt gcagggagcc ccaaccctct taaatgtcaa agaccctttt tgattaccca   1860

cactggtggt tattacagca tggttcccag ccttacagtg tctaagtgct tctcttgtgt   1920

cctgtagatg ttgtgaaaaa gaaaaaaaca aaaaatacac cacactgtac tttttccccc   1980

tgcccccgtt actgccggtg attattatta aaaattagtt tttttcacat catt         2034


<210>  3005
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  3005

Met Pro Ala Ile Ala Val Leu Ala Ala Ala Ala Ala Ala Trp Cys Phe 
1               5                   10                  15


Leu Gln Val Glu Ser Arg His Leu Asp Ala Leu Ala Gly Gly Ala Gly 
            20                  25                  30


Pro Asn His Gly Asn Phe Leu Asp Asn Asp Gln Trp Leu Ser Thr Val 
        35                  40                  45


Ser Gln Tyr Asp Arg Asp Lys Tyr Trp Asn Arg Phe Arg Asp Glu Val 
    50                  55                  60


Glu Asp Asp Tyr Phe Arg Asn Trp Asn Pro Asn Lys Pro Phe Asp Gln 
65                  70                  75                  80


Ala Leu Asp Pro Ser Lys Asp Pro Cys Leu Lys Val Lys Cys Ser Pro 
                85                  90                  95


His Lys Val Cys Val Thr Gln Asp Tyr Gln Thr Ala Leu Cys Val Ser 
            100                 105                 110


Arg Lys His Leu Leu Pro Arg Gln Lys Lys Gly Asn Val Ala Gln Lys 
        115                 120                 125


His Trp Val Gly Pro Ser Asn Leu Val Lys Cys Lys Pro Cys Pro Val 
    130                 135                 140


Ala Gln Ser Ala Met Val Cys Gly Ser Asp Gly His Ser Tyr Thr Ser 
145                 150                 155                 160


Lys Cys Lys Leu Glu Phe His Ala Cys Ser Thr Gly Lys Ser Leu Ala 
                165                 170                 175


Thr Leu Cys Asp Gly Pro Cys Pro Cys Leu Pro Glu Pro Glu Pro Pro 
            180                 185                 190


Lys His Lys Ala Glu Arg Ser Ala Cys Thr Asp Lys Glu Leu Arg Asn 
        195                 200                 205


Leu Ala Ser Arg Leu Lys Asp Trp Phe Gly Ala Leu His Glu Asp Ala 
    210                 215                 220


Asn Arg Val Ile Lys Pro Thr Ser Ser Asn Thr Ala Gln Gly Arg Phe 
225                 230                 235                 240


Asp Thr Ser Ile Leu Pro Ile Cys Lys Asp Ser Leu Gly Trp Met Phe 
                245                 250                 255


Asn Lys Leu Asp Met Asn Tyr Asp Leu Leu Leu Asp Pro Ser Glu Ile 
            260                 265                 270


Asn Ala Ile Tyr Leu Asp Lys Tyr Glu Pro Cys Ile Lys Pro Leu Phe 
        275                 280                 285


Asn Ser Cys Asp Ser Phe Lys Asp Gly Lys Leu Ser Asn Asn Glu Trp 
    290                 295                 300


Cys Tyr Cys Phe Gln Lys Pro Gly Gly Leu Pro Cys Gln Asn Glu Met 
305                 310                 315                 320


Asn Arg Ile Gln Lys Leu Ser Lys Gly Lys Ser Leu Leu Gly Ala Phe 
                325                 330                 335


Ile Pro Arg Cys Asn Glu Glu Gly Tyr Tyr Lys Ala Thr Gln Cys His 
            340                 345                 350


Gly Ser Thr Gly Gln Cys Trp Cys Val Asp Lys Tyr Gly Asn Glu Leu 
        355                 360                 365


Ala Gly Ser Arg Lys Gln Gly Ala Val Ser Cys Glu Glu Glu Gln Glu 
    370                 375                 380


Thr Ser Gly Asp Phe Gly Ser Gly Gly Ser Val Val Leu Leu Asp Asp 
385                 390                 395                 400


Leu Glu Tyr Glu Arg Glu Leu Gly Pro Lys Asp Lys Glu Gly Lys Leu 
                405                 410                 415


Arg Val His Thr Arg Ala Val Thr Glu Asp Asp Glu Asp Glu Asp Asp 
            420                 425                 430


Asp Lys Glu Asp Glu Val Gly Tyr Ile Trp 
        435                 440


<210>  3006
<211>  542
<212>  DNA
<213>  Homo sapiens

<400>  3006
taggtcctca ccagacacag aatctgccag taccctgacc ttggattttc gagcctccag     60

aactgtcaat gtcactgttc cgaagctaga cttgcagttc actgggaagc atgacaccac    120

agcacctcca gctgtggacg catcatggac aagccaggct gagaggagaa cttctcatta    180

cttgcagcac agcaacattg ggttcaatgt atgcccatga aaaacctcat ttaagagaat    240

gccttggaaa ggtgccaagg tccccaaact aattaacttt catctctcct ggccctctgc    300

accctctctc catgaggaac attaaacata gaacatcagc ttgagaacac tctatttaaa    360

gcaaaagtcc ttctaaagat agccttgaac gtccatctaa atcatcctaa gtccattttc    420

tggcccagaa tccacaaggc cagcgccccc gatgggccct actatggtgg cttatatcca    480

taaagaatgt ctttcacggt tcattggttg gattaatctg atataaagtg tctaaactga    540

aa                                                                   542


<210>  3007
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  3007

Met Thr Pro Gln His Leu Gln Leu Trp Thr His His Gly Gln Ala Arg 
1               5                   10                  15


Leu Arg Gly Glu Leu Leu Ile Thr Cys Ser Thr Ala Thr Leu Gly Ser 
            20                  25                  30


Met Tyr Ala His Glu Lys Pro His Leu Arg Glu Cys Leu Gly Lys Val 
        35                  40                  45


Pro Arg Ser Pro Asn 
    50


<210>  3008
<211>  566
<212>  DNA
<213>  Homo sapiens

<400>  3008
gcttttttgc tggtagacgc acaccatcac atcctacata atatttagct ctgaggcgtt     60

tccagatggg aagtgcgttt ctgtattttc atagccgtgt tctctacgtg aatggactgg    120

cgtgaagctg ggggctgacg gctggcaggg cagaacaact tccagtaaaa gaaggcactg    180

aggtttaagt gctacgtggg agcagttgcc gatttttgca atgggaggct gcatagattc    240

aaggacttcc ttgagtgctc caggagcttg tcattccaga gacagagcag cccagaagtc    300

ctgggattta cacctctagt agaaaccctc aaccagagaa ggatggaagt caatgggcag    360

agtgctcggg agacctttac ctgttttacc tgattacatc ctctgaggta tgtgccattt    420

atacctgggg aaactgaggc tcagaaaaat gaccttgtct gtggtcacac agctggtaag    480

gggtaggaat ggaatttaaa cccagttgtc taacttcagg gcccacattt cagccacaac    540

tgaggttttt cctaacctaa ccccat                                         566


<210>  3009
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  3009

Met Gly Gly Cys Ile Asp Ser Arg Thr Ser Leu Ser Ala Pro Gly Ala 
1               5                   10                  15


Cys His Ser Arg Asp Arg Ala Ala Gln Lys Ser Trp Asp Leu His Leu 
            20                  25                  30


<210>  3010
<211>  358
<212>  DNA
<213>  Homo sapiens

<400>  3010
cgcacaccat cacatcctac ataatattta gctctgaggc gtttccagat gggaagtgcg     60

tttctgtatt ttcatagccg tgttctctac gtgaatggac tggcgtgaag ctgggggctg    120

acggctggca gggcagaaca acttccagta aaagaaggca ctgaggttta agtgctacgt    180

gggagcagtt gccgattttt gcaatgggag gctgcataga ttcaagtgtg agaattcgaa    240

gagattcaaa gactatatca ccaccatggt cttgccagaa tctgccctct gagtcatttc    300

ttaatctact gattatctgt agaaccagcc ttatataaac aaggaagcat ctagcagg      358


<210>  3011
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  3011

Met Gly Gly Cys Ile Asp Ser Ser Val Arg Ile Arg Arg Asp Ser Lys 
1               5                   10                  15


Thr Ile Ser Pro Pro Trp Ser Cys Gln Asn Leu Pro Ser Glu Ser Phe 
            20                  25                  30


Leu Asn Leu Leu Ile Ile Cys Arg Thr Ser Leu Ile 
        35                  40


<210>  3012
<211>  4855
<212>  DNA
<213>  Homo sapiens

<400>  3012
atcgcctcct ccctccccaa gatggcgtcc ttgctgcagt cggaccgggt tctctatcta     60

gtccagggag aaaagaaggt tcgggccccg ctctcgcaac tctacttctg ccgctattgt    120

agcgaactgc ggtcgctgga atgtgtgtct cacgaggtaa cagagtcgcc ctatagcgag    180

tatgtggggt ggggggggcg cggcgttcat gctagtcact gccaccggaa ggctggagct    240

attttccttc cttactgatt ggttatgtct tccgtcactc gggtttgcct gcgatttaat    300

ttgcttctaa tctgtcactt ggaaaggagg agcagcctcg ggtgggactg agcggatctt    360

ctggttctag agcggcctct gattggacaa acttgactta gggaccgtgt ctgtctgcga    420

tggggcttgg taattgggtg gactacggag aaaggtctgg gggtgcttag ttcaggccac    480

ttaaggggcg aaaaactgcc tttccaggat ttattgcgag gatggaggga ggcgcaggcg    540

ttctcattca tagttctccc atcctgaaag ttctgttcct cttttgtcca gaaactgggc    600

cctcgtcaga ctgccttgcc ctgttcctga ctcaggccaa ggcctgcagc cgggaagagg    660

ttggggcggc gtgagttatg tgaaaagcgc tcagaataca gtatgtcatg taagaagctg    720

aaagtgtatt tatggagcta gaggacaatg ctgtccttcc ctggcacaag tgggcgtccg    780

aagttggatt tttcaaaaag aagaccccgg ccagtaaaaa gtcaccaaat aacaaaaccc    840

caaaacttct gcagcgcttg gcacatcttg tttattcagt aagctttagg gattaaaagg    900

tggactccca ttattgtccc agttgtttag aaaatatgcc atcggctgaa gccaaactaa    960

aaaagaatag atgtgccaat tgttttgact gtcctggctg catgcacacc ctctctactc   1020

gggccacgag catctccaca cagcttccag atgacccagc caagaccacc atgaagaaag   1080

cctattacct ggcatgtgga ttttgtcgct ggacgtctag agatgtgggc atggcagaca   1140

aatctgtagc tagtggcggt tggcaggaac ctgaaaatcc tcacacacaa cggatgaaca   1200

aattgattga atattaccag cagcttgctc agaaagagaa ggttgagcga gatcgcaaga   1260

aactggcacg acgtagaaac tatatgcctc tggctttttc ggacaaatat ggtcttggaa   1320

ccaggcttca gcgaccacga gctggtgcat ccatcagtac ccttgccgga ctttccctta   1380

aagaaggaga ggatcagaaa gagataaaga ttgagccagc tcaggctgtg gatgaagtgg   1440

aacctctacc tgaagactat tatacaagac cagtaaattt aacagaggta acaacccttc   1500

agcagcgtct gttacagcct gacttccagc cagtctgtgc ttcacagctc tatcctcgcc   1560

acaaacatct tctgatcaaa cggtccctgc gctgccgtaa atgtgaacat aatttgagca   1620

agccagaatt taacccaacg tcaatcaaat tcaaaatcca gctggtcgct gtcaattata   1680

ttccagaagt gagaatcatg tcaattccca accttcgcta catgaaggag agccaggtcc   1740

tcctgactct tacaaatcca gttgagaacc tcacccatgt gactctcttc gagtgtgagg   1800

agggggaccc tgatgatatc aacagcactg ctaaggtggt ggtgcctccc aaagagctcg   1860

ttttagctgg caaggatgca gcagcagagt acgatgagtt ggcagaacct caagactttc   1920

aggacgatcc tgacattata gccttcagaa aggccaacaa agtgggtatt ttcatcaaag   1980

ttacaccaca gcgtgaggag ggtgaagtga ccgtgtgctt caagatgaag catgatttta   2040

aaaacctggc agcccccatt cgccccattg aagaaagtga ccagggaaca gaagtcatct   2100

ggctcaccca gcatgtggaa cttagcttgg gcccacttct tccttaaaag gttccactgg   2160

agggcagatc ccaaaggaca gtatcaccgt aaacctgcgt taaaatgtgg aagctgctgc   2220

ttcattaggc cttgtttata acgatgtacc catgcactac ggaattctat tgctaagaaa   2280

gtgggagcat aggcaaggca ttgggaacac agggtagctg ctgttgctct tgctctcacc   2340

cctgttgaca ccagtaagtc tgtgtctccc tcactgaacc ctgcacgttg agtaacagca   2400

gcataattcc atcctaggaa aggggatggg tgttccttgg aatggcattg tatttaccac   2460

ctgagaaact ctgtactgtc tcttgatctg atctcactaa ggatcacaat gtcacagatg   2520

aaacttaaat gataacccaa aggtagacct gctgttaatg atccagcatt ggtcacaatg   2580

taccaactgc tttctgcatt ccgttaaata tcatctaaca gtctaaaaca tatcccttca   2640

ttgccataat ggctgccatt ttgccataga tttccatata actgaaaaac tgaattgtca   2700

ctttatcttt agtatcatga tgattggaaa aacctgtgaa gttgttaagg cactctcatt   2760

tgccctcttt ttctaagtga atacaggaca cgtattagtt gttcttaatt tttttcccag   2820

taaaatatgg atcttttaag aagaatttga gaagcaaaca attacatgtc atgtcaaggg   2880

ggtagcagat tccattcgtt ttcaatattg ccacaatacc cagggattaa tgctgccaca   2940

ggggggcaat ctttatttgt cttacttcct accccttccc tgttctgcct ctttaactca   3000

gttaagttgt tctgtttggg acctggaaaa gaacccaaag aaaacctgag tggacaggtt   3060

catttctgga atgcagaaaa cattttaaag gctagatttt tagaatattc tcaactagca   3120

ttctttccat tgatttgaag gggaaattaa ctattataat ctcttgaatc caaaactgga   3180

tattaagaac tttccccctt actaagttta agacttttgt catgtggtga gtcaaataag   3240

accattttga ttgtaaacca taaaatagtt cagcaagtag cccacagttc tggcctaaca   3300

gcagacttgc tgttttcact tggtatcctg gagttgggtt gctaacctta atttctatga   3360

tgttttctaa aatgaaactt gataaagtag accaccagct gcaccgtgtt ttctgtaaaa   3420

gtattgttag taagtggcca agagacttga ggaaaataca gattttttgt ttaccttggt   3480

cttgttttaa gtcttaaaaa attaaagata acattataat gtagaataca gatgggacat   3540

agtccttgta agcttccctt gaaaatgttt taaatattta ggaagctttt aaaagacact   3600

aaattgtact ctaaaagaca ctaaattgta ctaattgtac aaaggtcaag ccaattttat   3660

gaaacagtcc tacagagtaa tatatgtgat gcagtgtaag aaggaaaata ctcatctcta   3720

acattatggt aataacattt agcctcttag gagttggagc agggggatgg gtaattacag   3780

atttgcagac tatagaaaga gtttcatttt tttgtgaccc cacagagtct caaattttta   3840

tttcactacc tgctagagcc tactgtgaaa tcactgctcc atatttgcca gtggaggaaa   3900

tgggcataga gtagagaata gcttcatatg tttacacgtt tgcatagact acacacatgt   3960

catgcgttta tggcaggtag ctggtattta ttccccaaag taataatgtt gaagtatggg   4020

tctcatcatt cccatacaca gaaacacaaa acactttgat cataaacttt tttcttcaga   4080

agccaaacta acttgcagaa taatagagcc actggtttaa tgtttcctca agataggttt   4140

tagtgtaagc tagtattctg tgtgttcgta gaaatgattc aatacctgca gctggtgaat   4200

taggaattgt atttgttgcc ttttttatat tagatgaggt gcaaaaattt taatgctagt   4260

cagtatgcac caccacagga aagttagatc ccattagcac ttgaaactac agctttggaa   4320

acttaggcta agttaatttg gatttgttac ttgattcacc tactgacctt ttcttttgtt   4380

tgaagtgctt atcagcataa tgagctaagt gtcatgcata tttgtgaaga aacacccttt   4440

ttggtccctt ttgggacaga gaggtactcc ttgatcttta tgaatgacag gttactgttt   4500

tgccttattg cttaacttaa tgtagtgaaa taaagcagac aaagcttgag cgtgtctttt   4560

gtttgctctc atgtagatac taagtagcat ggctcagagc caaaagacaa gcgtgaagtt   4620

aagagagttg gctaagagag ttggtggggc atgctccctt ccattcctta aatgaagtaa   4680

tctaaaatct cttagcaggt tagttcacca taatatataa gtagatgttg ctttgagctt   4740

cttatataca tattcacaga accattatat aaatgttgtt agacctctac cagtttttat   4800

cctgggtcat tgcttctaaa gatatccttt acaatataca cagtggtctg actcc        4855


<210>  3013
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  3013

Met Pro Ser Ala Glu Ala Lys Leu Lys Lys Asn Arg Cys Ala Asn Cys 
1               5                   10                  15


Phe Asp Cys Pro Gly Cys Met His Thr Leu Ser Thr Arg Ala Thr Ser 
            20                  25                  30


Ile Ser Thr Gln Leu Pro Asp Asp Pro Ala Lys Thr Thr Met Lys Lys 
        35                  40                  45


Ala Tyr Tyr Leu Ala Cys Gly Phe Cys Arg Trp Thr Ser Arg Asp Val 
    50                  55                  60


Gly Met Ala Asp Lys Ser Val Ala Ser Gly Gly Trp Gln Glu Pro Glu 
65                  70                  75                  80


Asn Pro His Thr Gln Arg Met Asn Lys Leu Ile Glu Tyr Tyr Gln Gln 
                85                  90                  95


Leu Ala Gln Lys Glu Lys Val Glu Arg Asp Arg Lys Lys Leu Ala Arg 
            100                 105                 110


Arg Arg Asn Tyr Met Pro Leu Ala Phe Ser Asp Lys Tyr Gly Leu Gly 
        115                 120                 125


Thr Arg Leu Gln Arg Pro Arg Ala Gly Ala Ser Ile Ser Thr Leu Ala 
    130                 135                 140


Gly Leu Ser Leu Lys Glu Gly Glu Asp Gln Lys Glu Ile Lys Ile Glu 
145                 150                 155                 160


Pro Ala Gln Ala Val Asp Glu Val Glu Pro Leu Pro Glu Asp Tyr Tyr 
                165                 170                 175


Thr Arg Pro Val Asn Leu Thr Glu Val Thr Thr Leu Gln Gln Arg Leu 
            180                 185                 190


Leu Gln Pro Asp Phe Gln Pro Val Cys Ala Ser Gln Leu Tyr Pro Arg 
        195                 200                 205


His Lys His Leu Leu Ile Lys Arg Ser Leu Arg Cys Arg Lys Cys Glu 
    210                 215                 220


His Asn Leu Ser Lys Pro Glu Phe Asn Pro Thr Ser Ile Lys Phe Lys 
225                 230                 235                 240


Ile Gln Leu Val Ala Val Asn Tyr Ile Pro Glu Val Arg Ile Met Ser 
                245                 250                 255


Ile Pro Asn Leu Arg Tyr Met Lys Glu Ser Gln Val Leu Leu Thr Leu 
            260                 265                 270


Thr Asn Pro Val Glu Asn Leu Thr His Val Thr Leu Phe Glu Cys Glu 
        275                 280                 285


Glu Gly Asp Pro Asp Asp Ile Asn Ser Thr Ala Lys Val Val Val Pro 
    290                 295                 300


Pro Lys Glu Leu Val Leu Ala Gly Lys Asp Ala Ala Ala Glu Tyr Asp 
305                 310                 315                 320


Glu Leu Ala Glu Pro Gln Asp Phe Gln Asp Asp Pro Asp Ile Ile Ala 
                325                 330                 335


Phe Arg Lys Ala Asn Lys Val Gly Ile Phe Ile Lys Val Thr Pro Gln 
            340                 345                 350


Arg Glu Glu Gly Glu Val Thr Val Cys Phe Lys Met Lys His Asp Phe 
        355                 360                 365


Lys Asn Leu Ala Ala Pro Ile Arg Pro Ile Glu Glu Ser Asp Gln Gly 
    370                 375                 380


Thr Glu Val Ile Trp Leu Thr Gln His Val Glu Leu Ser Leu Gly Pro 
385                 390                 395                 400


Leu Leu Pro 



<210>  3014
<211>  4554
<212>  DNA
<213>  Homo sapiens

<400>  3014
atcgcctcct ccctccccaa gatggcgtcc ttgctgcagt cggaccgggt tctctatcta     60

gtccagggag aaaagaaggt tcgggccccg ctctcgcaac tctacttctg ccgctattgt    120

agcgaactgc ggtcgctgga atgtgtgtct cacgaggtaa cagagtcgcc ctatagcgag    180

tatgtggggt ggggggggcg cggcgttcat gctagtcact gccaccggaa ggctggagct    240

attttccttc cttactgatt ggttatgtct tccgtcactc gggtttgcct gcgatttaat    300

ttgcttctaa tctgtcactt ggaaaggagg agcagcctcg ggtgggactg agcggatctt    360

ctggttctag agcggcctct gattggacaa acttgactta gggaccgtgt ctgtctgcga    420

tggggcttgg taattgggtg gactacggag aaaggtctgg gggtgcttag ttcaggccac    480

ttaaggggcg aaaaactgcc tttccaggat ttattgcgag gatggaggga ggcgcaggcg    540

ttctcattca tagttctccc atcctgaaag ttctgttcct cttttgtcca gaaactgggc    600

cctcgtcaga ctgccttgcc ctgttcctga ctcaggccaa ggcctgcagc cgggaagagg    660

ttggggcggc gtgagttatg tgaaaagcgc tcagaataca gtatgtcatg taagaagctg    720

aaagtgtatt tatggagcta gaggacaatg ctgtccttcc ctggcacaag tgggcgtccg    780

aagttggatt tttcaaaaag aagaccccgg ccagtaaaaa gtcaccaaat aacaaaaccc    840

caaaacttct gcagcgcttg gcacatcttg tttattcagt aagctttagg gattaaaagg    900

tggactccca ttattgtccc agttgtttag aaaatatgcc atcggctgaa gccaaactaa    960

aaaagaatag atgtgccaat tgttttgact gtcctggctg catgcacacc ctctctactc   1020

gggccacgag catctccaca cagcttccag atgacccagc caagaccacc atgaagaaag   1080

cctattacct ggcatgtgga ttttgtcgct ggacgtctag agatgtgggc atggcagaca   1140

aatctgtagc tagtggcggt tggcaggaac ctgaaaatcc tcacacacaa cggatgaaca   1200

aattgattga atattaccag cagcttgctc agaaagagaa ggttgagcga gatcgcaaga   1260

aactggcacg acgtagaaac tatatgcctc tggctttttc ggacaaatat ggtcttggaa   1320

ccaggcttca gcgaccacga gctggtgcat ccatcagtac ccttgccgga ctttccctta   1380

aagaaggaga ggatcagaaa gagataaaga ttgagccagc tcaggctgtg gatgaagtgg   1440

aacctctacc tgaagactat tatacaagac cagtaaattt aacagaggta acaacccttc   1500

agcagcgtct gttacagcct gacttccagc cagtctgtgc ttcacagctc tatcctcgcc   1560

acaaacatct tctgatcaaa cggtccctgc gctgccgtaa atgtgaacat aatttgagca   1620

agccagaatt taacccaacg tcaatcaaat tcaaaatcca gctggtcgct gtcaattata   1680

ttccagaagt gagaatcatg tcaattccca accttcgcta catgaaggag agccaggtcc   1740

tcctgactct tacaaatcca gttgagaacc tcacccatgt gactctcttc gagtgtgagg   1800

agggggaccc tgatgatatc aacagcactg ctaaggtggt ggtgcctccc aaagagctcg   1860

ttttagctgg caaggatgca gcagcagagt acgatgagtt ggcagaacct caagactttc   1920

aggacgatcc tgacattata gccttcagaa aggccaacaa agtgggtatt ttcatcaaag   1980

ttacaccaca gcgtgaggag ggtgaagtga ccgtgtgctt caagatgaag catgatttta   2040

aaaacctggc agcccccatt cgccccattg aagaaagtga ccagggaaca gaagtcatct   2100

ggctcaccca gcatgtggaa cttagcttgg gcccacttct tccttaaaag gttccactgg   2160

agggcagatc ccaaaggaca gtatcaccgt aaacctgcgt taaaatgtgg aagctgctgc   2220

ttcattaggc cttgtttata acgatgtacc catgcactac ggaattctat tgctaagaaa   2280

gtgggagcat aggcaaggca ttgggaacac agggtagctg ctgttgctct tgctctcacc   2340

cctgttgaca ccagtaagtc tgtgtctccc tcactgaacc ctgcacgttg agtaacagca   2400

gcataattcc atcctaggaa aggggatggg tgttccttgg aatggcattg tatttaccac   2460

ctgagaaact ctgtactgtc tcttgatctg atctcactaa ggatcacaat gtcacagatg   2520

aaacttaaat gataacccaa aggtagacct gctgttaatg atccagcatt ggtcacaatg   2580

taccaactgc tttctgcatt ccgttaaata tcatctaaca gtctaaaaca tatcccttca   2640

ttgccataat ggctgccatt ttgccataga tttccatata actgaaaaac tgaattgtca   2700

ctttatcttt agtatcatga tgattggaaa aacctgtgaa gttgttaagg cactctcatt   2760

tgccctcttt ttctaagtga atacaggaca cgtattagtt gttcttaatt tttttcccag   2820

taaaatatgg atcttttaag aagaatttga gaagcaaaca attacatgtc atgtcaaggg   2880

ggtagcagat tccattcgtt ttcaatattg ccacaatacc cagggattaa tgctgccaca   2940

ggggggcaat ctttatttgt cttacttcct accccttccc tgttctgcct ctttaactca   3000

gttaagttgt tctgtttggg acctggaaaa gaacccaaag aaaacctgag tggacaggtt   3060

catttctgga atgcagaaaa cattttaaag gctagatttt tagaatattc tcaactagca   3120

ttctttccat tgatttgaag gggaaattaa ctattataat ctcttgaatc caaaactgga   3180

tattaagaac tttccccctt actaagttta agacttttgt catgtggtga gtcaaataag   3240

accattttga ttgtaaacca taaaatagtt cagcaagtag cccacagttc tggcctaaca   3300

gcagacttgc tgttttcact tggtatcctg gagttgggtt gctaacctta atttctatga   3360

tgttttctaa aatgaaactt gataaagtag accaccagct gcaccgtgtt ttctgtaaaa   3420

gtattgttag taagtggcca agagacttga ggaaaataca gattttttgt ttaccttggt   3480

cttgttttaa gtcttaaaaa attaaagata acattataat gtagaataca gatgggacat   3540

agtccttgta agcttccctt gaaaatgttt taaatattta ggaagctttt aaaagacact   3600

aaattgtact ctaaaagaca ctaaattgta ctaattgtac aaaggtcaag ccaattttat   3660

gaaacagtcc tacagagtaa tatatgtgat gcagtgtaag aaggaaaata ctcatctcta   3720

acattatggt aataacattt agcctcttag gagttggagc agggggatgg gtaattacag   3780

atttgcagac tatagaaaga gtttcatttt tttgtgaccc cacagagtct caaattttta   3840

tttcactacc tgctagagcc tactgtgaaa tcactgctcc atatttgcca gtggaggaaa   3900

tgggcataga gtagagaata gcttcatatg tttacacgtt tgcatagact acacacatgt   3960

catgcgttta tggcaggtag ctggtattta ttccccaaag taataatgtt gaagtatggg   4020

tctcatcatt cccatacaca gaaacacaaa acactttgat cataaacttt tttcttcaga   4080

agccaaacta acttgcagaa taatagagcc actggtttaa tgtttcctca agataggttt   4140

tagtgtaagc tagtattctg tgtgttcgta gaaatgattc aatacctgca gctggtgaat   4200

taggaattgt atttgttgcc ttttttatat tagatgaggt gcaaaaattt taatgctagt   4260

cagtatgcac caccacagga aagttagatc ccattagcac ttgaaactac agctttggaa   4320

acttaggcta agttaatttg gatttgttac ttgattcacc tactgacctt ttcttttgtt   4380

tgaagtgctt atcagcataa tgagctaagt gtcatgcata tttgtgaaga aacacccttt   4440

ttggtccctt ttgggacaga gaggtactcc ttgatcttta tgaatgacag gttactgttt   4500

tgccttattg cttaacttaa tgtagtgaaa taaagcagac aaagcttgag cgtg         4554


<210>  3015
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  3015

Met Pro Ser Ala Glu Ala Lys Leu Lys Lys Asn Arg Cys Ala Asn Cys 
1               5                   10                  15


Phe Asp Cys Pro Gly Cys Met His Thr Leu Ser Thr Arg Ala Thr Ser 
            20                  25                  30


Ile Ser Thr Gln Leu Pro Asp Asp Pro Ala Lys Thr Thr Met Lys Lys 
        35                  40                  45


Ala Tyr Tyr Leu Ala Cys Gly Phe Cys Arg Trp Thr Ser Arg Asp Val 
    50                  55                  60


Gly Met Ala Asp Lys Ser Val Ala Ser Gly Gly Trp Gln Glu Pro Glu 
65                  70                  75                  80


Asn Pro His Thr Gln Arg Met Asn Lys Leu Ile Glu Tyr Tyr Gln Gln 
                85                  90                  95


Leu Ala Gln Lys Glu Lys Val Glu Arg Asp Arg Lys Lys Leu Ala Arg 
            100                 105                 110


Arg Arg Asn Tyr Met Pro Leu Ala Phe Ser Asp Lys Tyr Gly Leu Gly 
        115                 120                 125


Thr Arg Leu Gln Arg Pro Arg Ala Gly Ala Ser Ile Ser Thr Leu Ala 
    130                 135                 140


Gly Leu Ser Leu Lys Glu Gly Glu Asp Gln Lys Glu Ile Lys Ile Glu 
145                 150                 155                 160


Pro Ala Gln Ala Val Asp Glu Val Glu Pro Leu Pro Glu Asp Tyr Tyr 
                165                 170                 175


Thr Arg Pro Val Asn Leu Thr Glu Val Thr Thr Leu Gln Gln Arg Leu 
            180                 185                 190


Leu Gln Pro Asp Phe Gln Pro Val Cys Ala Ser Gln Leu Tyr Pro Arg 
        195                 200                 205


His Lys His Leu Leu Ile Lys Arg Ser Leu Arg Cys Arg Lys Cys Glu 
    210                 215                 220


His Asn Leu Ser Lys Pro Glu Phe Asn Pro Thr Ser Ile Lys Phe Lys 
225                 230                 235                 240


Ile Gln Leu Val Ala Val Asn Tyr Ile Pro Glu Val Arg Ile Met Ser 
                245                 250                 255


Ile Pro Asn Leu Arg Tyr Met Lys Glu Ser Gln Val Leu Leu Thr Leu 
            260                 265                 270


Thr Asn Pro Val Glu Asn Leu Thr His Val Thr Leu Phe Glu Cys Glu 
        275                 280                 285


Glu Gly Asp Pro Asp Asp Ile Asn Ser Thr Ala Lys Val Val Val Pro 
    290                 295                 300


Pro Lys Glu Leu Val Leu Ala Gly Lys Asp Ala Ala Ala Glu Tyr Asp 
305                 310                 315                 320


Glu Leu Ala Glu Pro Gln Asp Phe Gln Asp Asp Pro Asp Ile Ile Ala 
                325                 330                 335


Phe Arg Lys Ala Asn Lys Val Gly Ile Phe Ile Lys Val Thr Pro Gln 
            340                 345                 350


Arg Glu Glu Gly Glu Val Thr Val Cys Phe Lys Met Lys His Asp Phe 
        355                 360                 365


Lys Asn Leu Ala Ala Pro Ile Arg Pro Ile Glu Glu Ser Asp Gln Gly 
    370                 375                 380


Thr Glu Val Ile Trp Leu Thr Gln His Val Glu Leu Ser Leu Gly Pro 
385                 390                 395                 400


Leu Leu Pro 



<210>  3016
<211>  3906
<212>  DNA
<213>  Homo sapiens

<400>  3016
gtgggaaacc taacgtcaaa gtctacgtag gaagtcgtag ggaaggcagc gaggaagacg     60

ctggctctcg ggtcacgtga tgcgccggga gcgtcatcgc ctcctccctc cccaagatgg    120

cgtccttgct gcagtcggac cgggttctct atctagtcca gggagaaaag aaggttcggg    180

ccccgctctc gcaactctac ttctgccgct attgtagcga actgcggtcg ctggaatgtg    240

tgtctcacga ggtggactcc cattattgtc ccagttgttt agaaaatatg ccatcggctg    300

aagccaaact aaaaaagaat agatgtgcca attgttttga ctgtcctggc tgcatgcaca    360

ccctctctac tcgggccacg agcatctcca cacagcttcc agatgaccca gccaagacca    420

ccatgaagaa agcctattac ctggcatgtg gattttgtcg ctggacgtct agagatgtgg    480

gcatggcaga caaatctgta gctagtggcg gttggcagga acctgaaaat cctcacacac    540

aacggatgaa caaattgatt gaatattacc agcagcttgc tcagaaagag aaggttgagc    600

gagatcgcaa gaaactggca cgacgtagaa actatatgcc tctggctttt tcggacaaat    660

atggtcttgg aaccaggctt cagcgaccac gagctggtgc atccatcagt acccttgccg    720

gactttccct taaagaagga gaggatcaga aagagataaa gattgagcca gctcaggctg    780

tggatgaagt ggaacctcta cctgaagact attatacaag accagtaaat ttaacagagg    840

taacaaccct tcagcagcgt ctgttacagc ctgacttcca gccagtctgt gcttcacagc    900

tctatcctcg ccacaaacat cttctgatca aacggtccct gcgctgccgt aaatgtgaac    960

ataatttgag caagccagaa tttaacccaa cgtcaatcaa attcaaaatc cagctggtcg   1020

ctgtcaatta tattccagaa gtgagaatca tgtcaattcc caaccttcgc tacatgaagg   1080

agagccaggt cctcctgact cttacaaatc cagttgagaa cctcacccat gtgactctct   1140

tcgagtgtga ggagggggac cctgatgata tcaacagcac tgctaaggtg gtggtgcctc   1200

ccaaagagct cgttttagct ggcaaggatg cagcagcaga gtacgatgag ttggcagaac   1260

ctcaagactt tcaggacgat cctgacatta tagccttcag aaaggccaac aaagtgggta   1320

ttttcatcaa agttacacca cagcgtgagg agggtgaagt gaccgtgtgc ttcaagatga   1380

agcatgattt taaaaacctg gcagccccca ttcgccccat tgaagaaagt gaccagggaa   1440

cagaagtcat ctggctcacc cagcatgtgg aacttagctt gggcccactt cttccttaaa   1500

aggttccact ggagggcaga tcccaaagga cagtatcacc gtaaacctgc gttaaaatgt   1560

ggaagctgct gcttcattag gccttgttta taacgatgta cccatgcact acggaattct   1620

attgctaaga aagtgggagc ataggcaagg cattgggaac acagggtagc tgctgttgct   1680

cttgctctca cccctgttga caccagtaag tctgtgtctc cctcactgaa ccctgcacgt   1740

tgagtaacag cagcataatt ccatcctagg aaaggggatg ggtgttcctt ggaatggcat   1800

tgtatttacc acctgagaaa ctctgtactg tctcttgatc tgatctcact aaggatcaca   1860

atgtcacaga tgaaacttaa atgataaccc aaaggtagac ctgctgttaa tgatccagca   1920

ttggtcacaa tgtaccaact gctttctgca ttccgttaaa tatcatctaa cagtctaaaa   1980

catatccctt cattgccata atggctgcca ttttgccata gatttccata taactgaaaa   2040

actgaattgt cactttatct ttagtatcat gatgattgga aaaacctgtg aagttgttaa   2100

ggcactctca tttgccctct ttttctaagt gaatacagga cacgtattag ttgttcttaa   2160

tttttttccc agtaaaatat ggatctttta agaagaattt gagaagcaaa caattacatg   2220

tcatgtcaag ggggtagcag attccattcg ttttcaatat tgccacaata cccagggatt   2280

aatgctgcca caggggggca atctttattt gtcttacttc ctaccccttc cctgttctgc   2340

ctctttaact cagttaagtt gttctgtttg ggacctggaa aagaacccaa agaaaacctg   2400

agtggacagg ttcatttctg gaatgcagaa aacattttaa aggctagatt tttagaatat   2460

tctcaactag cattctttcc attgatttga aggggaaatt aactattata atctcttgaa   2520

tccaaaactg gatattaaga actttccccc ttactaagtt taagactttt gtcatgtggt   2580

gagtcaaata agaccatttt gattgtaaac cataaaatag ttcagcaagt agcccacagt   2640

tctggcctaa cagcagactt gctgttttca cttggtatcc tggagttggg ttgctaacct   2700

taatttctat gatgttttct aaaatgaaac ttgataaagt agaccaccag ctgcaccgtg   2760

ttttctgtaa aagtattgtt agtaagtggc caagagactt gaggaaaata cagatttttt   2820

gtttaccttg gtcttgtttt aagtcttaaa aaattaaaga taacattata atgtagaata   2880

cagatgggac atagtccttg taagcttccc ttgaaaatgt tttaaatatt taggaagctt   2940

ttaaaagaca ctaaattgta ctctaaaaga cactaaattg tactaattgt acaaaggtca   3000

agccaatttt atgaaacagt cctacagagt aatatatgtg atgcagtgta agaaggaaaa   3060

tactcatctc taacattatg gtaataacat ttagcctctt aggagttgga gcagggggat   3120

gggtaattac agatttgcag actatagaaa gagtttcatt tttttgtgac cccacagagt   3180

ctcaaatttt tatttcacta cctgctagag cctactgtga aatcactgct ccatatttgc   3240

cagtggagga aatgggcata gagtagagaa tagcttcata tgtttacacg tttgcataga   3300

ctacacacat gtcatgcgtt tatggcaggt agctggtatt tattccccaa agtaataatg   3360

ttgaagtatg ggtctcatca ttcccataca cagaaacaca aaacactttg atcataaact   3420

tttttcttca gaagccaaac taacttgcag aataatagag ccactggttt aatgtttcct   3480

caagataggt tttagtgtaa gctagtattc tgtgtgttcg tagaaatgat tcaatacctg   3540

cagctggtga attaggaatt gtatttgttg ccttttttat attagatgag gtgcaaaaat   3600

tttaatgcta gtcagtatgc accaccacag gaaagttaga tcccattagc acttgaaact   3660

acagctttgg aaacttaggc taagttaatt tggatttgtt acttgattca cctactgacc   3720

ttttcttttg tttgaagtgc ttatcagcat aatgagctaa gtgtcatgca tatttgtgaa   3780

gaaacaccct ttttggtccc ttttgggaca gagaggtact ccttgatctt tatgaatgac   3840

aggttactgt tttgccttat tgcttaactt aatgtagtga aataaagcag acaaagcttg   3900

agcgtg                                                              3906


<210>  3017
<211>  460
<212>  PRT
<213>  Homo sapiens

<400>  3017

Met Ala Ser Leu Leu Gln Ser Asp Arg Val Leu Tyr Leu Val Gln Gly 
1               5                   10                  15


Glu Lys Lys Val Arg Ala Pro Leu Ser Gln Leu Tyr Phe Cys Arg Tyr 
            20                  25                  30


Cys Ser Glu Leu Arg Ser Leu Glu Cys Val Ser His Glu Val Asp Ser 
        35                  40                  45


His Tyr Cys Pro Ser Cys Leu Glu Asn Met Pro Ser Ala Glu Ala Lys 
    50                  55                  60


Leu Lys Lys Asn Arg Cys Ala Asn Cys Phe Asp Cys Pro Gly Cys Met 
65                  70                  75                  80


His Thr Leu Ser Thr Arg Ala Thr Ser Ile Ser Thr Gln Leu Pro Asp 
                85                  90                  95


Asp Pro Ala Lys Thr Thr Met Lys Lys Ala Tyr Tyr Leu Ala Cys Gly 
            100                 105                 110


Phe Cys Arg Trp Thr Ser Arg Asp Val Gly Met Ala Asp Lys Ser Val 
        115                 120                 125


Ala Ser Gly Gly Trp Gln Glu Pro Glu Asn Pro His Thr Gln Arg Met 
    130                 135                 140


Asn Lys Leu Ile Glu Tyr Tyr Gln Gln Leu Ala Gln Lys Glu Lys Val 
145                 150                 155                 160


Glu Arg Asp Arg Lys Lys Leu Ala Arg Arg Arg Asn Tyr Met Pro Leu 
                165                 170                 175


Ala Phe Ser Asp Lys Tyr Gly Leu Gly Thr Arg Leu Gln Arg Pro Arg 
            180                 185                 190


Ala Gly Ala Ser Ile Ser Thr Leu Ala Gly Leu Ser Leu Lys Glu Gly 
        195                 200                 205


Glu Asp Gln Lys Glu Ile Lys Ile Glu Pro Ala Gln Ala Val Asp Glu 
    210                 215                 220


Val Glu Pro Leu Pro Glu Asp Tyr Tyr Thr Arg Pro Val Asn Leu Thr 
225                 230                 235                 240


Glu Val Thr Thr Leu Gln Gln Arg Leu Leu Gln Pro Asp Phe Gln Pro 
                245                 250                 255


Val Cys Ala Ser Gln Leu Tyr Pro Arg His Lys His Leu Leu Ile Lys 
            260                 265                 270


Arg Ser Leu Arg Cys Arg Lys Cys Glu His Asn Leu Ser Lys Pro Glu 
        275                 280                 285


Phe Asn Pro Thr Ser Ile Lys Phe Lys Ile Gln Leu Val Ala Val Asn 
    290                 295                 300


Tyr Ile Pro Glu Val Arg Ile Met Ser Ile Pro Asn Leu Arg Tyr Met 
305                 310                 315                 320


Lys Glu Ser Gln Val Leu Leu Thr Leu Thr Asn Pro Val Glu Asn Leu 
                325                 330                 335


Thr His Val Thr Leu Phe Glu Cys Glu Glu Gly Asp Pro Asp Asp Ile 
            340                 345                 350


Asn Ser Thr Ala Lys Val Val Val Pro Pro Lys Glu Leu Val Leu Ala 
        355                 360                 365


Gly Lys Asp Ala Ala Ala Glu Tyr Asp Glu Leu Ala Glu Pro Gln Asp 
    370                 375                 380


Phe Gln Asp Asp Pro Asp Ile Ile Ala Phe Arg Lys Ala Asn Lys Val 
385                 390                 395                 400


Gly Ile Phe Ile Lys Val Thr Pro Gln Arg Glu Glu Gly Glu Val Thr 
                405                 410                 415


Val Cys Phe Lys Met Lys His Asp Phe Lys Asn Leu Ala Ala Pro Ile 
            420                 425                 430


Arg Pro Ile Glu Glu Ser Asp Gln Gly Thr Glu Val Ile Trp Leu Thr 
        435                 440                 445


Gln His Val Glu Leu Ser Leu Gly Pro Leu Leu Pro 
    450                 455                 460


<210>  3018
<211>  2824
<212>  DNA
<213>  Homo sapiens

<400>  3018
gtgggaaacc taacgtcaaa gtctacgtag gaagtcgtag ggaaggcagc gaggaagacg     60

ctggctctcg ggtcacgtga tgcgccggga gcgtcatcgc ctcctccctc cccaagatgg    120

cgtccttgct gcagtcggac cgggttctct atctagtcca gggagaaaag aaggttcggg    180

ccccgctctc gcaactctac ttctgccgct attgtagcga actgcggtcg ctggaatgtg    240

tgtctcacga ggtggactcc cattattgtc ccagttgttt agaaaatatg ccatcggctg    300

aagccaaact aaaaaagaat agatgtgcca attgttttga ctgtcctggc tgcatgcaca    360

ccctctctac tcgggccacg agcatctcca cacagcttcc agatgaccca gccaagacca    420

ccatgaagaa agcctattac ctggcatgtg gattttgtcg ctggacgtct agagatgtgg    480

gcatggcaga caaatctgta gctagtggcg gttggcagga acctgaaaat cctcacacac    540

aacggatgaa caaattgatt gaatattacc agcagcttgc tcagaaagag aaggttgagc    600

gagatcgcaa gaaactggca cgacgtagaa actatatgcc tctggctttt tcggacaaat    660

atggtcttgg aaccaggctt cagcgaccac gagctggtgc atccatcagt acccttgccg    720

gactttccct taaagaagga gaggatcaga aagagataaa gattgagcca gctcaggctg    780

tggatgaagt ggaacctcta cctgaagact attatacaag accagtaaat ttaacagagg    840

taacaaccct tcagcagcgt ctgttacagc ctgacttcca gccagtctgt gcttcacagc    900

tctatcctcg ccacaaacat cttctgatca aacggtccct gcgctgccgt aaatgtgaac    960

ataatttgag caagccagaa tttaacccaa cgtcaatcaa attcaaaatc cagctggtcg   1020

ctgtcaatta tattccagaa gtgagaatca tgtcaattcc caaccttcgc tacatgaagg   1080

agagccaggt cctcctgact cttacaaatc cagttgagaa cctcacccat gtgactctct   1140

tcgagtgtga ggagggggac cctgatgata tcaacagcac tgctaaggtg gtggtgcctc   1200

ccaaagagct cgttttagct ggcaaggatg cagcagcaga gtacgatgag ttggcagaac   1260

ctcaagactt tcaggacgat cctgacatta tagccttcag aaaggccaac aaagtgggta   1320

ttttcatcaa agttacacca cagcgtgagg agggtgaagt gaccgtgtgc ttcaagatga   1380

agcatgattt taaaaacctg gcagccccca ttcgccccat tgaagaaagt gaccagggaa   1440

cagaagtcat ctggctcacc cagcatgtgg aacttagctt gggcccactt cttccttaaa   1500

aggttccact ggagggcaga tcccaaagga cagtatcacc gtaaacctgc gttaaaatgt   1560

ggaagctgct gcttcattag gccttgttta taacgatgta cccatgcact acggaattct   1620

attgctaaga aagtgggagc ataggcaagg cattgggaac acagggtagc tgctgttgct   1680

cttgctctca cccctgttga caccagtaag tctgtgtctc cctcactgaa ccctgcacgt   1740

tgagtaacag cagcataatt ccatcctagg aaaggggatg ggtgttcctt ggaatggcat   1800

tgtatttacc acctgagaaa ctctgtactg tctcttgatc tgatctcact aaggatcaca   1860

atgtcacaga tgaaacttaa atgataaccc aaaggtagac ctgctgttaa tgatccagca   1920

ttggtcacaa tgtaccaact gctttctgca ttccgttaaa tatcatctaa cagtctaaaa   1980

catatccctt cattgccata atggctgcca ttttgccata gatttccata taactgaaaa   2040

actgaattgt cactttatct ttagtatcat gatgattgga aaaacctgtg aagttgttaa   2100

ggcactctca tttgccctct ttttctaagt gaatacagga cacgtattag ttgttcttaa   2160

tttttttccc agtaaaatat ggatctttta agaagaattt gagaagcaaa caattacatg   2220

tcatgtcaag ggggtagcag attccattcg ttttcaatat tgccacaata cccagggatt   2280

aatgctgcca caggggggca atctttattt gtcttacttc ctaccccttc cctgttctgc   2340

ctctttaact cagttaagtt gttctgtttg ggacctggaa aagaacccaa agaaaacctg   2400

agtggacagg ttcatttctg gaatgcagaa aacattttaa aggctagatt tttagaatat   2460

tctcaactag cattctttcc attgatttga aggggaaatt aactattata atctcttgaa   2520

tccaaaactg gatattaaga actttccccc ttactaagtt taagactttt gtcatgtggt   2580

gagtcaaata agaccatttt gattgtaaac cataaaatag ttcagcaagt agcccacagt   2640

tctggcctaa cagcagactt gctgttttca cttggtatcc tggagttggg ttgctaacct   2700

taatttctat gatgttttct aaaatgaaac ttgataaagt agaccaccag ctgcaccgtg   2760

ttttctgtaa aagtattgtt agtaagtggc caagagactt gaggaaaata cagatttttt   2820

gttt                                                                2824


<210>  3019
<211>  460
<212>  PRT
<213>  Homo sapiens

<400>  3019

Met Ala Ser Leu Leu Gln Ser Asp Arg Val Leu Tyr Leu Val Gln Gly 
1               5                   10                  15


Glu Lys Lys Val Arg Ala Pro Leu Ser Gln Leu Tyr Phe Cys Arg Tyr 
            20                  25                  30


Cys Ser Glu Leu Arg Ser Leu Glu Cys Val Ser His Glu Val Asp Ser 
        35                  40                  45


His Tyr Cys Pro Ser Cys Leu Glu Asn Met Pro Ser Ala Glu Ala Lys 
    50                  55                  60


Leu Lys Lys Asn Arg Cys Ala Asn Cys Phe Asp Cys Pro Gly Cys Met 
65                  70                  75                  80


His Thr Leu Ser Thr Arg Ala Thr Ser Ile Ser Thr Gln Leu Pro Asp 
                85                  90                  95


Asp Pro Ala Lys Thr Thr Met Lys Lys Ala Tyr Tyr Leu Ala Cys Gly 
            100                 105                 110


Phe Cys Arg Trp Thr Ser Arg Asp Val Gly Met Ala Asp Lys Ser Val 
        115                 120                 125


Ala Ser Gly Gly Trp Gln Glu Pro Glu Asn Pro His Thr Gln Arg Met 
    130                 135                 140


Asn Lys Leu Ile Glu Tyr Tyr Gln Gln Leu Ala Gln Lys Glu Lys Val 
145                 150                 155                 160


Glu Arg Asp Arg Lys Lys Leu Ala Arg Arg Arg Asn Tyr Met Pro Leu 
                165                 170                 175


Ala Phe Ser Asp Lys Tyr Gly Leu Gly Thr Arg Leu Gln Arg Pro Arg 
            180                 185                 190


Ala Gly Ala Ser Ile Ser Thr Leu Ala Gly Leu Ser Leu Lys Glu Gly 
        195                 200                 205


Glu Asp Gln Lys Glu Ile Lys Ile Glu Pro Ala Gln Ala Val Asp Glu 
    210                 215                 220


Val Glu Pro Leu Pro Glu Asp Tyr Tyr Thr Arg Pro Val Asn Leu Thr 
225                 230                 235                 240


Glu Val Thr Thr Leu Gln Gln Arg Leu Leu Gln Pro Asp Phe Gln Pro 
                245                 250                 255


Val Cys Ala Ser Gln Leu Tyr Pro Arg His Lys His Leu Leu Ile Lys 
            260                 265                 270


Arg Ser Leu Arg Cys Arg Lys Cys Glu His Asn Leu Ser Lys Pro Glu 
        275                 280                 285


Phe Asn Pro Thr Ser Ile Lys Phe Lys Ile Gln Leu Val Ala Val Asn 
    290                 295                 300


Tyr Ile Pro Glu Val Arg Ile Met Ser Ile Pro Asn Leu Arg Tyr Met 
305                 310                 315                 320


Lys Glu Ser Gln Val Leu Leu Thr Leu Thr Asn Pro Val Glu Asn Leu 
                325                 330                 335


Thr His Val Thr Leu Phe Glu Cys Glu Glu Gly Asp Pro Asp Asp Ile 
            340                 345                 350


Asn Ser Thr Ala Lys Val Val Val Pro Pro Lys Glu Leu Val Leu Ala 
        355                 360                 365


Gly Lys Asp Ala Ala Ala Glu Tyr Asp Glu Leu Ala Glu Pro Gln Asp 
    370                 375                 380


Phe Gln Asp Asp Pro Asp Ile Ile Ala Phe Arg Lys Ala Asn Lys Val 
385                 390                 395                 400


Gly Ile Phe Ile Lys Val Thr Pro Gln Arg Glu Glu Gly Glu Val Thr 
                405                 410                 415


Val Cys Phe Lys Met Lys His Asp Phe Lys Asn Leu Ala Ala Pro Ile 
            420                 425                 430


Arg Pro Ile Glu Glu Ser Asp Gln Gly Thr Glu Val Ile Trp Leu Thr 
        435                 440                 445


Gln His Val Glu Leu Ser Leu Gly Pro Leu Leu Pro 
    450                 455                 460


<210>  3020
<211>  500
<212>  DNA
<213>  Homo sapiens

<400>  3020
tgaatcatgt gatgcttgcc aaaaccgctg aggacatggg aaagaagttc tacattgtct     60

ggaccaagct agacatggac ctcagcacag gtgccctccc agaagtgcag ctactgcaga    120

tcagagaaaa tgtcctggaa aatctccaga aggagcggag ctctagaaac caacaagtgt    180

acccaaacca cagccacgta cctcttgctt gctgaaagga tcctgagaga aaagcaagac    240

aaagaaatac agatcagctc cgcaagccct agaaatagca aggcccagct cagctggcct    300

gccatgagaa atacctcaag agtactccag agaattccac aaggcccaga aatattcctt    360

ccagaagaaa actatacgta aatctgctca ggatattcaa cagctagcca gtgcatatga    420

catatactgg gtacttaaga aacgtttgtt aaatgaatca tgattataaa gaaaaaataa    480

attaaaactt atgtttagtt                                                500


<210>  3021
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  3021

Met Ser Trp Lys Ile Ser Arg Arg Ser Gly Ala Leu Glu Thr Asn Lys 
1               5                   10                  15


Cys Thr Gln Thr Thr Ala Thr Tyr Leu Leu Leu Ala Glu Arg Ile Leu 
            20                  25                  30


Arg Glu Lys Gln Asp Lys Glu Ile Gln Ile Ser Ser Ala Ser Pro Arg 
        35                  40                  45


Asn Ser Lys Ala Gln Leu Ser Trp Pro Ala Met Arg Asn Thr Ser Arg 
    50                  55                  60


Val Leu Gln Arg Ile Pro Gln Gly Pro Glu Ile Phe Leu Pro Glu Glu 
65                  70                  75                  80


Asn Tyr Thr 



<210>  3022
<211>  4015
<212>  DNA
<213>  Homo sapiens

<400>  3022
tattatacaa aactaggtgt ggatgtagtt gtgcacatta tagcagaaat tatgagaatg     60

atcatttcag attgaacagg aatttactat tacaggggtt agtatcattc aaggatgtgg    120

ctgtggattt cacccaggag gagtggcagc aacttgaccc ttctcagagg accctgtaca    180

gggatgtgat gctggagaac tacagccacc tggtctcaat ggggtatcca gtttccaaac    240

cagatgtcat ctccaagttg gaacaaggag aagagccatg gatcataaag ggagacatat    300

caaattggat ctatccagat gaatatcagg cagatgggag acaagggaag tgaaatatca    360

atttatgttt ttttaattga ttggtgcctg aggtttatgt ttctatcctt atcaaaatct    420

cctattcttt gcttctatgc tgagaattta gtagtcactc aacaagtaat tgtgaagcct    480

ttcagaggag ttctatttgt tgttgatcct gtctcttgtg tgtatatata tatgtttata    540

tttgttgtct ttcctgaaag ggttttaaag gcaatagaag gcaaattcct ttcaagaaca    600

caagctgtgc tttaaaaggc aatattccca gataaatgac tgtattaaat taaatgtcaa    660

atacagttac tgttttagaa gttcagagaa aattaagagt ctaaagagat gtgagcgtat    720

ttgagaaaca tttttcagag catgcaactg taactgctct gaatgacata aatgctgatg    780

aggctgaagg aggagggtga aggcaagcag tgttggagag agagtatatg aacaaaacct    840

tagggtcagg aagatacagc ttttctggga gaactttact agttttactt gacatgtata    900

gaaagtagtt tattgggagt agtggaattt acgtctgtat tctcagtttg actctgatac    960

tgaatctgta gcaggatatt ggatttttct attatttgtt agttgttagg aaaatagatg   1020

gaggagagtt aaagtatttt gcatacagaa gataccttgt tttttagagt gatggtagga   1080

taataagaat gtgtagcaca tgatttataa tataaatgaa attaaaaggt gaaaaggggt   1140

ttctattcag aaagcagaag tgaaatattc tagaagaata atcaaaaatt agtgatgaga   1200

ccccactttt tcatctcttt taagtttagt ttttacatga atatttctgt ttaacattct   1260

tgtctgtcta ttcacctgat aacactatat gctgtactgt cttctgagat gacctgtttc   1320

catccttttt ttgtgagttc atctactatg ttggatcatc catttgttct acttctttac   1380

cctcttaatt gactcttgtg atgactctta aattgtatct tttcttcttt tagacaggaa   1440

gagtaacctt cacaactccc agtcatgtat tttggggaca gtttccttcc atcataagat   1500

actgaaagga gtcacaaggg atggttcatt gtgctccatt ttaaaagtct gtcaaggtga   1560

tggtcagctg cagagatttc tagagaatca agacaaactc ttcaggcagg tcacatttgt   1620

taacagcaaa acagtgactg aggcatcagg gcataaatat aatccactgg ggaaaatatt   1680

tcaagagtgc atagaaacag atatatcaat acagagattc cataaatatg atgcttttaa   1740

aaagaactta aaaccaaata ttgacctacc gagttgttat aagagcaatt caagaaaaaa   1800

acctgatcag agttttggag gtggaaaatc atctagccag agtgagccca attctaatct   1860

tgagaagatt cacaatggag taataccttt tgatgataat cagtgtggaa acgtttttag   1920

aaatacacaa tcccttattc aatatcagaa tgtggaaact aaagagaaaa gctgtgtatg   1980

tgttacatgt ggaaaagcct ttgctaagaa gtcacaactc attgtacatc aaagaattca   2040

tactggaaag aaaccatatg attgtggtgc atgcggaaaa gccttcagtg agaagtttca   2100

tcttgttgta catcagagaa ctcatactgg ggagaaacct tatgattgtt ctgaatgtgg   2160

aaaagccttc tctcagaaat cgtcccttat tatacatcag agagttcaca ctggggaaaa   2220

accctatgaa tgtagtgaat gcgggaaagc cttctcccag aaatcacccc tcattataca   2280

tcagagaata catactgggg aaaaacccta tgaatgtaga gagtgtggga aggccttttc   2340

ccagaagtca cagctgatta tacaccacag agctcatact ggagagaagc cgtatgagtg   2400

taccgaatgt gggaaagcct tctgtgagaa gtcccacctc attatacata aaagaattca   2460

cactggtgag aaaccctaca aatgtgctca atgtgaggaa gccttcagca ggaagacaga   2520

actcattaca catcagttag ttcatactgg ggaaaaacct tatgaatgta ctgaatgtgg   2580

aaagacattc tcccgcaagt cacagctcat catacatcag agaacacata ctggagaaaa   2640

accctataaa tgtagtgaat gtggcaaagc cttctgccag aagtcacatc tcattggaca   2700

tcagagaatt cacacaggag aaaaacctta tatatgtact gaatgtggga aagccttctc   2760

tcagaagtcc caccttccgg gacaccagcg aattcataca ggagagaaac cttacatatg   2820

tgctgaatgt ggaaaggcct tttctcagaa gtcagacctt gttttacatc agaggattca   2880

tactggggaa agaccctatc aatgtgctat atgtgggaag gccttcatcc agaagtcaca   2940

actaactgta caccagagaa ttcacacagt ggtaaaatca taatgaactg gccacagaaa   3000

agccttagta ttagctcaag ccttaataat tactagaaac ccaattaatt tgataagctt   3060

ggggacaaca tcccaataga taaaaatttt taagggaatt tgtttctagt ttggtgatgc   3120

ctaacttttc cagcaaagat gatggaaaat agttatataa atgaagaaca tttttaatat   3180

ggcatgtaaa gcttttaaag ttatgaactc agtgatcagc acagcaagtt aagcatacag   3240

aatattgtca agttgcatat tccttatact acaaaatgat aatcagccat tgtgaaactg   3300

ctaatattag cttgtcataa ttatggccat aaactaattt ttctataaaa gacgtggaag   3360

aaagcttaag taaacaataa aataaaacct atacactatt ttaagaaggg gcttgagcat   3420

gacccctaaa gctacatgta aagttcttgt acaaaaaatg gaatgatagg ttgatcagat   3480

tcagtaaagt tgatctgtat gcattttccc atctcaagca tataagttga cctgcatctc   3540

tggaaggacc ttgagattga tgcattttga gcaggtctcc cttttactct tcccaactgg   3600

gaacttggag ctgaaaaaca ttggcactga ggccagatgg ccttgggttt aatcctggct   3660

cagtgcctca cagattgtgt gactttaggc aaacatactt ctcctagctg agtatttttt   3720

atcagtaagt acaaatacaa tgcagagctc attttcagtt aatattagta ctttttaaat   3780

ctttactctc tatcttgaag cattagatgt taagactaat gtgtaaaaac cacgtctgag   3840

cttgcttttc cctctggaca ctctgctttt gattgcctat ccctataagt ggctcatttt   3900

actgtcttct gatcctggtg gccttatttt tgctatgtta aggttgtgtt ttttaatact   3960

tggatttatt ttcatatact tacataaacc gtggtgattg cacataaaga ccctg        4015


<210>  3023
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  3023

Met Leu Glu Asn Tyr Ser His Leu Val Ser Met Gly Tyr Pro Val Ser 
1               5                   10                  15


Lys Pro Asp Val Ile Ser Lys Leu Glu Gln Gly Glu Glu Pro Trp Ile 
            20                  25                  30


Ile Lys Gly Asp Ile Ser Asn Trp Ile Tyr Pro Asp Glu Tyr Gln Ala 
        35                  40                  45


Asp Gly Arg Gln Gly Lys 
    50


<210>  3024
<211>  3223
<212>  DNA
<213>  Homo sapiens

<400>  3024
acgaagacga ccgggctctc aagatggcgg ccccatgcgg aaacagctcc agggagcagc     60

catgttgctt cctgaacaaa gcctctgaag atgcggaacg ggcaaaaccg cccagtacgg    120

aacggcgcag cctcgggagc ccggtgtggt gctcgcggac aggaagcagg agagtttgcc    180

aatagggatg tgacagcggt tcccattaag cggtgatggt ggttttggga cctgataatc    240

gagctgggag tcagaggcgg gatgtgtgcg gtgaaggatg ttttgatacc cccatataaa    300

ataatctgtc tgtcatggga gcccccacgt cctctgaaat agttcagctc tgtctgcatg    360

acttgtcctg ggactgagga aaatttacca ggggttagta tcattcaagg atgtggctgt    420

ggatttcacc caggaggagt ggcagcaact tgacccttct cagaggaccc tgtacaggga    480

tgtgatgctg gagaactaca gccacctggt ctcaatgggg tatccagttt ccaaaccaga    540

tgtcatctcc aagttggaac aaggagaaga gccatggatc ataaagggag acatatcaaa    600

ttggatctat ccagatgaat atcaggcaga tgggagacaa gggaagaaga gtaaccttca    660

caactcccag tcatgtattt tggggacagt ttccttccat cataagatac tgaaaggagt    720

cacaagggat ggttcattgt gctccatttt aaaagtctgt caaggtgatg gtcagctgca    780

gagatttcta gagaatcaag acaaactctt caggcaggtc acatttgtta acagcaaaac    840

agtgactgag gcatcagggc ataaatataa tccactgggg aaaatatttc aagagtgcat    900

agaaacagat atatcaatac agagattcca taaatatgat gcttttaaaa agaacttaaa    960

accaaatatt gacctaccga gttgttataa gagcaattca agaaaaaaac ctgatcagag   1020

ttttggaggt ggaaaatcat ctagccagag tgagcccaat tctaatcttg agaagattca   1080

caatggagta ataccttttg atgataatca gtgtggaaac gtttttagaa atacacaatc   1140

ccttattcaa tatcagaatg tggaaactaa agagaaaagc tgtgtatgtg ttacatgtgg   1200

aaaagccttt gctaagaagt cacaactcat tgtacatcaa agaattcata ctggaaagaa   1260

accatatgat tgtggtgcat gcggaaaagc cttcagtgag aagtttcatc ttgttgtaca   1320

tcagagaact catactgggg agaaacctta tgattgttct gaatgtggaa aagccttctc   1380

tcagaaatcg tcccttatta tacatcagag agttcacact ggggaaaaac cctatgaatg   1440

tagtgaatgc gggaaagcct tctcccagaa atcacccctc attatacatc agagaataca   1500

tactggggaa aaaccctatg aatgtagaga gtgtgggaag gccttttccc agaagtcaca   1560

gctgattata caccacagag ctcatactgg agagaagccg tatgagtgta ccgaatgtgg   1620

gaaagccttc tgtgagaagt cccacctcat tatacataaa agaattcaca ctggtgagaa   1680

accctacaaa tgtgctcaat gtgaggaagc cttcagcagg aagacagaac tcattacaca   1740

tcagttagtt catactgggg aaaaacctta tgaatgtact gaatgtggaa agacattctc   1800

ccgcaagtca cagctcatca tacatcagag aacacatact ggagaaaaac cctataaatg   1860

tagtgaatgt ggcaaagcct tctgccagaa gtcacatctc attggacatc agagaattca   1920

cacaggagaa aaaccttata tatgtactga atgtgggaaa gccttctctc agaagtccca   1980

ccttccggga caccagcgaa ttcatacagg agagaaacct tacatatgtg ctgaatgtgg   2040

aaaggccttt tctcagaagt cagaccttgt tttacatcag aggattcata ctggggaaag   2100

accctatcaa tgtgctatat gtgggaaggc cttcatccag aagtcacaac taactgtaca   2160

ccagagaatt cacacagtgg taaaatcata atgaactggc cacagaaaag ccttagtatt   2220

agctcaagcc ttaataatta ctagaaaccc aattaatttg ataagcttgg ggacaacatc   2280

ccaatagata aaaattttta agggaatttg tttctagttt ggtgatgcct aacttttcca   2340

gcaaagatga tggaaaatag ttatataaat gaagaacatt tttaatatgg catgtaaagc   2400

ttttaaagtt atgaactcag tgatcagcac agcaagttaa gcatacagaa tattgtcaag   2460

ttgcatattc cttatactac aaaatgataa tcagccattg tgaaactgct aatattagct   2520

tgtcataatt atggccataa actaattttt ctataaaaga cgtggaagaa agcttaagta   2580

aacaataaaa taaaacctat acactatttt aagaaggggc ttgagcatga cccctaaagc   2640

tacatgtaaa gttcttgtac aaaaaatgga atgataggtt gatcagattc agtaaagttg   2700

atctgtatgc attttcccat ctcaagcata taagttgacc tgcatctctg gaaggacctt   2760

gagattgatg cattttgagc aggtctccct tttactcttc ccaactggga acttggagct   2820

gaaaaacatt ggcactgagg ccagatggcc ttgggtttaa tcctggctca gtgcctcaca   2880

gattgtgtga ctttaggcaa acatacttct cctagctgag tattttttat cagtaagtac   2940

aaatacaatg cagagctcat tttcagttaa tattagtact ttttaaatct ttactctcta   3000

tcttgaagca ttagatgtta agactaatgt gtaaaaacca cgtctgagct tgcttttccc   3060

tctggacact ctgcttttga ttgcctatcc ctataagtgg ctcattttac tgtcttctga   3120

tcctggtggc cttatttttg ctatgttaag gttgtgtttt ttaatacttg gatttatttt   3180

catatactta cataaaccgt ggtgattgca cataaagacc ctg                     3223


<210>  3025
<211>  568
<212>  PRT
<213>  Homo sapiens

<400>  3025

Met Leu Glu Asn Tyr Ser His Leu Val Ser Met Gly Tyr Pro Val Ser 
1               5                   10                  15


Lys Pro Asp Val Ile Ser Lys Leu Glu Gln Gly Glu Glu Pro Trp Ile 
            20                  25                  30


Ile Lys Gly Asp Ile Ser Asn Trp Ile Tyr Pro Asp Glu Tyr Gln Ala 
        35                  40                  45


Asp Gly Arg Gln Gly Lys Lys Ser Asn Leu His Asn Ser Gln Ser Cys 
    50                  55                  60


Ile Leu Gly Thr Val Ser Phe His His Lys Ile Leu Lys Gly Val Thr 
65                  70                  75                  80


Arg Asp Gly Ser Leu Cys Ser Ile Leu Lys Val Cys Gln Gly Asp Gly 
                85                  90                  95


Gln Leu Gln Arg Phe Leu Glu Asn Gln Asp Lys Leu Phe Arg Gln Val 
            100                 105                 110


Thr Phe Val Asn Ser Lys Thr Val Thr Glu Ala Ser Gly His Lys Tyr 
        115                 120                 125


Asn Pro Leu Gly Lys Ile Phe Gln Glu Cys Ile Glu Thr Asp Ile Ser 
    130                 135                 140


Ile Gln Arg Phe His Lys Tyr Asp Ala Phe Lys Lys Asn Leu Lys Pro 
145                 150                 155                 160


Asn Ile Asp Leu Pro Ser Cys Tyr Lys Ser Asn Ser Arg Lys Lys Pro 
                165                 170                 175


Asp Gln Ser Phe Gly Gly Gly Lys Ser Ser Ser Gln Ser Glu Pro Asn 
            180                 185                 190


Ser Asn Leu Glu Lys Ile His Asn Gly Val Ile Pro Phe Asp Asp Asn 
        195                 200                 205


Gln Cys Gly Asn Val Phe Arg Asn Thr Gln Ser Leu Ile Gln Tyr Gln 
    210                 215                 220


Asn Val Glu Thr Lys Glu Lys Ser Cys Val Cys Val Thr Cys Gly Lys 
225                 230                 235                 240


Ala Phe Ala Lys Lys Ser Gln Leu Ile Val His Gln Arg Ile His Thr 
                245                 250                 255


Gly Lys Lys Pro Tyr Asp Cys Gly Ala Cys Gly Lys Ala Phe Ser Glu 
            260                 265                 270


Lys Phe His Leu Val Val His Gln Arg Thr His Thr Gly Glu Lys Pro 
        275                 280                 285


Tyr Asp Cys Ser Glu Cys Gly Lys Ala Phe Ser Gln Lys Ser Ser Leu 
    290                 295                 300


Ile Ile His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Glu Cys Ser 
305                 310                 315                 320


Glu Cys Gly Lys Ala Phe Ser Gln Lys Ser Pro Leu Ile Ile His Gln 
                325                 330                 335


Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys 
            340                 345                 350


Ala Phe Ser Gln Lys Ser Gln Leu Ile Ile His His Arg Ala His Thr 
        355                 360                 365


Gly Glu Lys Pro Tyr Glu Cys Thr Glu Cys Gly Lys Ala Phe Cys Glu 
    370                 375                 380


Lys Ser His Leu Ile Ile His Lys Arg Ile His Thr Gly Glu Lys Pro 
385                 390                 395                 400


Tyr Lys Cys Ala Gln Cys Glu Glu Ala Phe Ser Arg Lys Thr Glu Leu 
                405                 410                 415


Ile Thr His Gln Leu Val His Thr Gly Glu Lys Pro Tyr Glu Cys Thr 
            420                 425                 430


Glu Cys Gly Lys Thr Phe Ser Arg Lys Ser Gln Leu Ile Ile His Gln 
        435                 440                 445


Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Ser Glu Cys Gly Lys 
    450                 455                 460


Ala Phe Cys Gln Lys Ser His Leu Ile Gly His Gln Arg Ile His Thr 
465                 470                 475                 480


Gly Glu Lys Pro Tyr Ile Cys Thr Glu Cys Gly Lys Ala Phe Ser Gln 
                485                 490                 495


Lys Ser His Leu Pro Gly His Gln Arg Ile His Thr Gly Glu Lys Pro 
            500                 505                 510


Tyr Ile Cys Ala Glu Cys Gly Lys Ala Phe Ser Gln Lys Ser Asp Leu 
        515                 520                 525


Val Leu His Gln Arg Ile His Thr Gly Glu Arg Pro Tyr Gln Cys Ala 
    530                 535                 540


Ile Cys Gly Lys Ala Phe Ile Gln Lys Ser Gln Leu Thr Val His Gln 
545                 550                 555                 560


Arg Ile His Thr Val Val Lys Ser 
                565


<210>  3026
<211>  4353
<212>  DNA
<213>  Homo sapiens

<400>  3026
acgaagacga ccgggctctc aagatggcgg ccccatgcgg aaacagctcc agggagcagc     60

catgttgctt cctgaacaaa gcctctgaag atgcggaacg ggcaaaaccg cccagtacgg    120

aacggcgcag cctcgggagc ccggtgtggt gctcgcggac aggaagcagg agagtttgcc    180

aatagggatg tgacagcggt tcccattaag cggtgatggt ggttttggga cctgataatc    240

gagctgggag tcagaggcgg gatgtgtgcg gtgaaggatg ttttgatacc cccatataaa    300

ataatctgtc tgtcatggga gcccccacgt cctctgaaat agttcagctc tgtctgcatg    360

acttgtcctg ggactgagga aaatttacca gtcatctggc cttttggaag agcaaaaaat    420

gatgaagtcc caggggttag tatcattcaa ggatgtggct gtggatttca cccaggagga    480

gtggcagcaa cttgaccctt ctcagaggac cctgtacagg gatgtgatgc tggagaacta    540

cagccacctg gtctcaatgg ggtatccagt ttccaaacca gatgtcatct ccaagttgga    600

acaaggagaa gagccatgga tcataaaggg agacatatca aattggatct atccagatga    660

atatcaggca gatgggagac aagggaagtg aaatatcaat ttatgttttt ttaattgatt    720

ggtgcctgag gtttatgttt ctatccttat caaaatctcc tattctttgc ttctatgctg    780

agaatttagt agtcactcaa caagtaattg tgaagccttt cagaggagtt ctatttgttg    840

ttgatcctgt ctcttgtgtg tatatatata tgtttatatt tgttgtcttt cctgaaaggg    900

ttttaaaggc aatagaaggc aaattccttt caagaacaca agctgtgctt taaaaggcaa    960

tattcccaga taaatgactg tattaaatta aatgtcaaat acagttactg ttttagaagt   1020

tcagagaaaa ttaagagtct aaagagatgt gagcgtattt gagaaacatt tttcagagca   1080

tgcaactgta actgctctga atgacataaa tgctgatgag gctgaaggag gagggtgaag   1140

gcaagcagtg ttggagagag agtatatgaa caaaacctta gggtcaggaa gatacagctt   1200

ttctgggaga actttactag ttttacttga catgtataga aagtagttta ttgggagtag   1260

tggaatttac gtctgtattc tcagtttgac tctgatactg aatctgtagc aggatattgg   1320

atttttctat tatttgttag ttgttaggaa aatagatgga ggagagttaa agtattttgc   1380

atacagaaga taccttgttt tttagagtga tggtaggata ataagaatgt gtagcacatg   1440

atttataata taaatgaaat taaaaggtga aaaggggttt ctattcagaa agcagaagtg   1500

aaatattcta gaagaataat caaaaattag tgatgagacc ccactttttc atctctttta   1560

agtttagttt ttacatgaat atttctgttt aacattcttg tctgtctatt cacctgataa   1620

cactatatgc tgtactgtct tctgagatga cctgtttcca tccttttttt gtgagttcat   1680

ctactatgtt ggatcatcca tttgttctac ttctttaccc tcttaattga ctcttgtgat   1740

gactcttaaa ttgtatcttt tcttctttta gacaggaaga gtaaccttca caactcccag   1800

tcatgtattt tggggacagt ttccttccat cataagatac tgaaaggagt cacaagggat   1860

ggttcattgt gctccatttt aaaagtctgt caaggtgatg gtcagctgca gagatttcta   1920

gagaatcaag acaaactctt caggcaggtc acatttgtta acagcaaaac agtgactgag   1980

gcatcagggc ataaatataa tccactgggg aaaatatttc aagagtgcat agaaacagat   2040

atatcaatac agagattcca taaatatgat gcttttaaaa agaacttaaa accaaatatt   2100

gacctaccga gttgttataa gagcaattca agaaaaaaac ctgatcagag ttttggaggt   2160

ggaaaatcat ctagccagag tgagcccaat tctaatcttg agaagattca caatggagta   2220

ataccttttg atgataatca gtgtggaaac gtttttagaa atacacaatc ccttattcaa   2280

tatcagaatg tggaaactaa agagaaaagc tgtgtatgtg ttacatgtgg aaaagccttt   2340

gctaagaagt cacaactcat tgtacatcaa agaattcata ctggaaagaa accatatgat   2400

tgtggtgcat gcggaaaagc cttcagtgag aagtttcatc ttgttgtaca tcagagaact   2460

catactgggg agaaacctta tgattgttct gaatgtggaa aagccttctc tcagaaatcg   2520

tcccttatta tacatcagag agttcacact ggggaaaaac cctatgaatg tagtgaatgc   2580

gggaaagcct tctcccagaa atcacccctc attatacatc agagaataca tactggggaa   2640

aaaccctatg aatgtagaga gtgtgggaag gccttttccc agaagtcaca gctgattata   2700

caccacagag ctcatactgg agagaagccg tatgagtgta ccgaatgtgg gaaagccttc   2760

tgtgagaagt cccacctcat tatacataaa agaattcaca ctggtgagaa accctacaaa   2820

tgtgctcaat gtgaggaagc cttcagcagg aagacagaac tcattacaca tcagttagtt   2880

catactgggg aaaaacctta tgaatgtact gaatgtggaa agacattctc ccgcaagtca   2940

cagctcatca tacatcagag aacacatact ggagaaaaac cctataaatg tagtgaatgt   3000

ggcaaagcct tctgccagaa gtcacatctc attggacatc agagaattca cacaggagaa   3060

aaaccttata tatgtactga atgtgggaaa gccttctctc agaagtccca ccttccggga   3120

caccagcgaa ttcatacagg agagaaacct tacatatgtg ctgaatgtgg aaaggccttt   3180

tctcagaagt cagaccttgt tttacatcag aggattcata ctggggaaag accctatcaa   3240

tgtgctatat gtgggaaggc cttcatccag aagtcacaac taactgtaca ccagagaatt   3300

cacacagtgg taaaatcata atgaactggc cacagaaaag ccttagtatt agctcaagcc   3360

ttaataatta ctagaaaccc aattaatttg ataagcttgg ggacaacatc ccaatagata   3420

aaaattttta agggaatttg tttctagttt ggtgatgcct aacttttcca gcaaagatga   3480

tggaaaatag ttatataaat gaagaacatt tttaatatgg catgtaaagc ttttaaagtt   3540

atgaactcag tgatcagcac agcaagttaa gcatacagaa tattgtcaag ttgcatattc   3600

cttatactac aaaatgataa tcagccattg tgaaactgct aatattagct tgtcataatt   3660

atggccataa actaattttt ctataaaaga cgtggaagaa agcttaagta aacaataaaa   3720

taaaacctat acactatttt aagaaggggc ttgagcatga cccctaaagc tacatgtaaa   3780

gttcttgtac aaaaaatgga atgataggtt gatcagattc agtaaagttg atctgtatgc   3840

attttcccat ctcaagcata taagttgacc tgcatctctg gaaggacctt gagattgatg   3900

cattttgagc aggtctccct tttactcttc ccaactggga acttggagct gaaaaacatt   3960

ggcactgagg ccagatggcc ttgggtttaa tcctggctca gtgcctcaca gattgtgtga   4020

ctttaggcaa acatacttct cctagctgag tattttttat cagtaagtac aaatacaatg   4080

cagagctcat tttcagttaa tattagtact ttttaaatct ttactctcta tcttgaagca   4140

ttagatgtta agactaatgt gtaaaaacca cgtctgagct tgcttttccc tctggacact   4200

ctgcttttga ttgcctatcc ctataagtgg ctcattttac tgtcttctga tcctggtggc   4260

cttatttttg ctatgttaag gttgtgtttt ttaatacttg gatttatttt catatactta   4320

cataaaccgt ggtgattgca cataaagacc ctg                                4353


<210>  3027
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  3027

Met Met Lys Ser Gln Gly Leu Val Ser Phe Lys Asp Val Ala Val Asp 
1               5                   10                  15


Phe Thr Gln Glu Glu Trp Gln Gln Leu Asp Pro Ser Gln Arg Thr Leu 
            20                  25                  30


Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser His Leu Val Ser Met Gly 
        35                  40                  45


Tyr Pro Val Ser Lys Pro Asp Val Ile Ser Lys Leu Glu Gln Gly Glu 
    50                  55                  60


Glu Pro Trp Ile Ile Lys Gly Asp Ile Ser Asn Trp Ile Tyr Pro Asp 
65                  70                  75                  80


Glu Tyr Gln Ala Asp Gly Arg Gln Gly Lys 
                85                  90


<210>  3028
<211>  3268
<212>  DNA
<213>  Homo sapiens

<400>  3028
agtacgaaga cgaccgggct ctcaagatgg cggccccatg cggaaacagc tccagggagc     60

agccatgttg cttcctgaac aaagcctctg aagatgcgga acgggcaaaa ccgcccagta    120

cggaacggcg cagcctcggg agcccggtgt ggtgctcgcg gacaggaagc aggagagttt    180

gccaataggg atgtgacagc ggttcccatt aagcggtgat ggtggttttg ggacctgata    240

atcgagctgg gagtcagagg cgggatgtgt gcggtgaagg atgttttgat acccccatat    300

aaaataatct gtctgtcatg ggagccccca cgtcctctga aatagttcag ctctgtctgc    360

atgacttgtc ctgggactga ggaaaattta ccagtcatct ggccttttgg aagagcaaaa    420

aatgatgaag tcccaggggt tagtatcatt caaggatgtg gctgtggatt tcacccagga    480

ggagtggcag caacttgacc cttctcagag gaccctgtac agggatgtga tgctggagaa    540

ctacagccac ctggtctcaa tggggtatcc agtttccaaa ccagatgtca tctccaagtt    600

ggaacaagga gaagagccat ggatcataaa gggagacata tcaaattgga tctatccaga    660

tgaatatcag gcagatggga gacaagggaa gaagagtaac cttcacaact cccagtcatg    720

tattttgggg acagtttcct tccatcataa gatactgaaa ggagtcacaa gggatggttc    780

attgtgctcc attttaaaag tctgtcaagg tgatggtcag ctgcagagat ttctagagaa    840

tcaagacaaa ctcttcaggc aggtcacatt tgttaacagc aaaacagtga ctgaggcatc    900

agggcataaa tataatccac tggggaaaat atttcaagag tgcatagaaa cagatatatc    960

aatacagaga ttccataaat atgatgcttt taaaaagaac ttaaaaccaa atattgacct   1020

accgagttgt tataagagca attcaagaaa aaaacctgat cagagttttg gaggtggaaa   1080

atcatctagc cagagtgagc ccaattctaa tcttgagaag attcacaatg gagtaatacc   1140

ttttgatgat aatcagtgtg gaaacgtttt tagaaataca caatccctta ttcaatatca   1200

gaatgtggaa actaaagaga aaagctgtgt atgtgttaca tgtggaaaag cctttgctaa   1260

gaagtcacaa ctcattgtac atcaaagaat tcatactgga aagaaaccat atgattgtgg   1320

tgcatgcgga aaagccttca gtgagaagtt tcatcttgtt gtacatcaga gaactcatac   1380

tggggagaaa ccttatgatt gttctgaatg tggaaaagcc ttctctcaga aatcgtccct   1440

tattatacat cagagagttc acactgggga aaaaccctat gaatgtagtg aatgcgggaa   1500

agccttctcc cagaaatcac ccctcattat acatcagaga atacatactg gggaaaaacc   1560

ctatgaatgt agagagtgtg ggaaggcctt ttcccagaag tcacagctga ttatacacca   1620

cagagctcat actggagaga agccgtatga gtgtaccgaa tgtgggaaag ccttctgtga   1680

gaagtcccac ctcattatac ataaaagaat tcacactggt gagaaaccct acaaatgtgc   1740

tcaatgtgag gaagccttca gcaggaagac agaactcatt acacatcagt tagttcatac   1800

tggggaaaaa ccttatgaat gtactgaatg tggaaagaca ttctcccgca agtcacagct   1860

catcatacat cagagaacac atactggaga aaaaccctat aaatgtagtg aatgtggcaa   1920

agccttctgc cagaagtcac atctcattgg acatcagaga attcacacag gagaaaaacc   1980

ttatatatgt actgaatgtg ggaaagcctt ctctcagaag tcccaccttc cgggacacca   2040

gcgaattcat acaggagaga aaccttacat atgtgctgaa tgtggaaagg ccttttctca   2100

gaagtcagac cttgttttac atcagaggat tcatactggg gaaagaccct atcaatgtgc   2160

tatatgtggg aaggccttca tccagaagtc acaactaact gtacaccaga gaattcacac   2220

agtggtaaaa tcataatgaa ctggccacag aaaagcctta gtattagctc aagccttaat   2280

aattactaga aacccaatta atttgataag cttggggaca acatcccaat agataaaaat   2340

ttttaaggga atttgtttct agtttggtga tgcctaactt ttccagcaaa gatgatggaa   2400

aatagttata taaatgaaga acatttttaa tatggcatgt aaagctttta aagttatgaa   2460

ctcagtgatc agcacagcaa gttaagcata cagaatattg tcaagttgca tattccttat   2520

actacaaaat gataatcagc cattgtgaaa ctgctaatat tagcttgtca taattatggc   2580

cataaactaa tttttctata aaagacgtgg aagaaagctt aagtaaacaa taaaataaaa   2640

cctatacact attttaagaa ggggcttgag catgacccct aaagctacat gtaaagttct   2700

tgtacaaaaa atggaatgat aggttgatca gattcagtaa agttgatctg tatgcatttt   2760

cccatctcaa gcatataagt tgacctgcat ctctggaagg accttgagat tgatgcattt   2820

tgagcaggtc tcccttttac tcttcccaac tgggaacttg gagctgaaaa acattggcac   2880

tgaggccaga tggccttggg tttaatcctg gctcagtgcc tcacagattg tgtgacttta   2940

ggcaaacata cttctcctag ctgagtattt tttatcagta agtacaaata caatgcagag   3000

ctcattttca gttaatatta gtacttttta aatctttact ctctatcttg aagcattaga   3060

tgttaagact aatgtgtaaa aaccacgtct gagcttgctt ttccctctgg acactctgct   3120

tttgattgcc tatccctata agtggctcat tttactgtct tctgatcctg gtggccttat   3180

ttttgctatg ttaaggttgt gttttttaat acttggattt attttcatat acttacataa   3240

accgtggtga ttgcacataa agaccctg                                      3268


<210>  3029
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  3029

Met Met Lys Ser Gln Gly Leu Val Ser Phe Lys Asp Val Ala Val Asp 
1               5                   10                  15


Phe Thr Gln Glu Glu Trp Gln Gln Leu Asp Pro Ser Gln Arg Thr Leu 
            20                  25                  30


Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser His Leu Val Ser Met Gly 
        35                  40                  45


Tyr Pro Val Ser Lys Pro Asp Val Ile Ser Lys Leu Glu Gln Gly Glu 
    50                  55                  60


Glu Pro Trp Ile Ile Lys Gly Asp Ile Ser Asn Trp Ile Tyr Pro Asp 
65                  70                  75                  80


Glu Tyr Gln Ala Asp Gly Arg Gln Gly Lys Lys Ser Asn Leu His Asn 
                85                  90                  95


Ser Gln Ser Cys Ile Leu Gly Thr Val Ser Phe His His Lys Ile Leu 
            100                 105                 110


Lys Gly Val Thr Arg Asp Gly Ser Leu Cys Ser Ile Leu Lys Val Cys 
        115                 120                 125


Gln Gly Asp Gly Gln Leu Gln Arg Phe Leu Glu Asn Gln Asp Lys Leu 
    130                 135                 140


Phe Arg Gln Val Thr Phe Val Asn Ser Lys Thr Val Thr Glu Ala Ser 
145                 150                 155                 160


Gly His Lys Tyr Asn Pro Leu Gly Lys Ile Phe Gln Glu Cys Ile Glu 
                165                 170                 175


Thr Asp Ile Ser Ile Gln Arg Phe His Lys Tyr Asp Ala Phe Lys Lys 
            180                 185                 190


Asn Leu Lys Pro Asn Ile Asp Leu Pro Ser Cys Tyr Lys Ser Asn Ser 
        195                 200                 205


Arg Lys Lys Pro Asp Gln Ser Phe Gly Gly Gly Lys Ser Ser Ser Gln 
    210                 215                 220


Ser Glu Pro Asn Ser Asn Leu Glu Lys Ile His Asn Gly Val Ile Pro 
225                 230                 235                 240


Phe Asp Asp Asn Gln Cys Gly Asn Val Phe Arg Asn Thr Gln Ser Leu 
                245                 250                 255


Ile Gln Tyr Gln Asn Val Glu Thr Lys Glu Lys Ser Cys Val Cys Val 
            260                 265                 270


Thr Cys Gly Lys Ala Phe Ala Lys Lys Ser Gln Leu Ile Val His Gln 
        275                 280                 285


Arg Ile His Thr Gly Lys Lys Pro Tyr Asp Cys Gly Ala Cys Gly Lys 
    290                 295                 300


Ala Phe Ser Glu Lys Phe His Leu Val Val His Gln Arg Thr His Thr 
305                 310                 315                 320


Gly Glu Lys Pro Tyr Asp Cys Ser Glu Cys Gly Lys Ala Phe Ser Gln 
                325                 330                 335


Lys Ser Ser Leu Ile Ile His Gln Arg Val His Thr Gly Glu Lys Pro 
            340                 345                 350


Tyr Glu Cys Ser Glu Cys Gly Lys Ala Phe Ser Gln Lys Ser Pro Leu 
        355                 360                 365


Ile Ile His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Arg 
    370                 375                 380


Glu Cys Gly Lys Ala Phe Ser Gln Lys Ser Gln Leu Ile Ile His His 
385                 390                 395                 400


Arg Ala His Thr Gly Glu Lys Pro Tyr Glu Cys Thr Glu Cys Gly Lys 
                405                 410                 415


Ala Phe Cys Glu Lys Ser His Leu Ile Ile His Lys Arg Ile His Thr 
            420                 425                 430


Gly Glu Lys Pro Tyr Lys Cys Ala Gln Cys Glu Glu Ala Phe Ser Arg 
        435                 440                 445


Lys Thr Glu Leu Ile Thr His Gln Leu Val His Thr Gly Glu Lys Pro 
    450                 455                 460


Tyr Glu Cys Thr Glu Cys Gly Lys Thr Phe Ser Arg Lys Ser Gln Leu 
465                 470                 475                 480


Ile Ile His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Ser 
                485                 490                 495


Glu Cys Gly Lys Ala Phe Cys Gln Lys Ser His Leu Ile Gly His Gln 
            500                 505                 510


Arg Ile His Thr Gly Glu Lys Pro Tyr Ile Cys Thr Glu Cys Gly Lys 
        515                 520                 525


Ala Phe Ser Gln Lys Ser His Leu Pro Gly His Gln Arg Ile His Thr 
    530                 535                 540


Gly Glu Lys Pro Tyr Ile Cys Ala Glu Cys Gly Lys Ala Phe Ser Gln 
545                 550                 555                 560


Lys Ser Asp Leu Val Leu His Gln Arg Ile His Thr Gly Glu Arg Pro 
                565                 570                 575


Tyr Gln Cys Ala Ile Cys Gly Lys Ala Phe Ile Gln Lys Ser Gln Leu 
            580                 585                 590


Thr Val His Gln Arg Ile His Thr Val Val Lys Ser 
        595                 600


<210>  3030
<211>  3143
<212>  DNA
<213>  Homo sapiens

<400>  3030
agtacgaaga cgaccgggct ctcaagatgg cggccccatg cggaaacagc tccagggagc     60

agccatgttg cttcctgaac aaagcctctg aagatgcgga acgggcaaaa ccgcccagta    120

cggaacggcg cagcctcggg agcccggtgt ggtgctcgcg gacaggaagc aggagagttt    180

gccaataggg atgtgacagc ggttcccatt aagcggtgat ggtggttttg ggacctgata    240

atcgagctgg gagtcagagg cgggatgtgt gcggtgaagg atgttttgat acccccatat    300

aaaataatct gtctgtcatg ggagccccca cgtcctctga aatagttcag ctctgtctgc    360

atgacttgtc ctgggactga ggaaaattta ccagtcatct ggccttttgg aagagcaaaa    420

aatgatgaag tcccaggggt tagtatcatt caaggatgtg gctgtggatt tcacccagga    480

ggagtggcag caacttgacc cttctcagag gaccctgtac agggatgtga tgctggagaa    540

ctacagccac ctggtctcaa tggggtatcc agtttccaaa ccagatgtca tctccaagtt    600

ggaacaagga gaagagccat ggatcataaa gggagacata tcaaattgga tctatccaga    660

tgaatatcag gcagatggga gacaagggaa gaagagtaac cttcacaact cccagtcatg    720

tattttgggg acagtttcct tccatcataa gatactgaaa ggagtcacaa gggatggttc    780

attgtgctcc attttaaaag tctgtcaagg tgatggtcag ctgcagagat ttctagagaa    840

tcaagacaaa ctcttcaggc aggtcacatt tgttaacagc aaaacagtga ctgaggcatc    900

agggcataaa tataatccac tggggaaaat atttcaagag tgcatagaaa cagatatatc    960

aatacagaga ttccataaat atgatgcttt taaaaagaac ttaaaaccaa atattgacct   1020

accgagttgt tataagagca attcaagaaa aaaacctgat cagagttttg gaggtggaaa   1080

atcatctagc cagagtgagc ccaattctaa tcttgagaag attcacaatg gagtaatacc   1140

ttttgatgat aatcagtgtg gaaacgtttt tagaaataca caatccctta ttcaatatca   1200

gaatgtggaa actaaagaga aaagctgtgt atgtgttaca tgtggaaaag cctttgctaa   1260

gaagtcacaa ctcattgtac atcaaagaat tcatactgga aagaaaccat atgattgtgg   1320

tgcatgcgga aaagccttca gtgagaagtt tcatcttgtt gtacatcaga gaactcatac   1380

tggggagaaa ccttatgatt gttctgaatg tggaaaagcc ttctctcaga aatcgtccct   1440

tattatacat cagagagttc acactgggga aaaaccctat gaatgtagtg aatgcgggaa   1500

agccttctcc cagaaatcac ccctcattat acatcagaga atacatactg gggaaaaacc   1560

ctatgaatgt agagagtgtg ggaaggcctt ttcccagaag tcacagctga ttatacacca   1620

cagagctcat actggagaga agccgtatga gtgtaccgaa tgtgggaaag ccttctgtga   1680

gaagtcccac ctcattatac ataaaagaat tcacactggt gagaaaccct acaaatgtgc   1740

tcaatgtgag gaagccttca gcaggaagac agaactcatt acacatcagt tagttcatac   1800

tggggaaaaa ccttatgaat gtactgaatg tggaaagaca ttctcccgca agtcacagct   1860

catcatacat cagagaacac atactggaga aaaaccctat aaatgtagtg aatgtggcaa   1920

agccttctgc cagaagtcac atctcattgg acatcagaga attcacacag gagaaaaacc   1980

ttatatatgt actgaatgtg ggaaagcctt ctctcagaag tcccaccttc cgggacacca   2040

gcgaattcat acaggagaga aaccttacat atgtgctgaa tgtggaaagg ccttttctca   2100

gaagtcagac cttgttttac atcagaggat tcatactggg gaaagaccct atcaatgtgc   2160

tatatgtggg aaggccttca tccagaagtc acaactaact gtacaccaga gaattcacac   2220

agtggtaaaa tcataatgaa ctggccacag aaaagcctta gtattagctc aagccttaat   2280

aattactaga aacccaatta atttgataag cttggggaca acatcccaat agataaaaat   2340

ttttaaggga atttgtttct agtttggtga tgcctaactt ttccagcaaa gatgatggaa   2400

aatagttata taaatgaaga acatttttaa tatggcatgt aaagctttta aagttatgaa   2460

ctcagtgatc agcacagcaa gttaagcata cagaatattg tcaagttgca tattccttat   2520

actacaaaat gataatcagc cattgtgaaa ctgctaatat tagcttgtca taattatggc   2580

cataaactaa tttttctata aaagacgtgg aagaaagctt aagtaaacaa taaaataaaa   2640

cctatacact attttaagaa ggggcttgag catgacccct aaagctacat gtaaagttct   2700

tgtacaaaaa atggaatgat aggttgatca gattcagtaa agttgatctg tatgcatttt   2760

cccatctcaa gcatataagt tgacctgcat ctctggaagg accttgagat tgatgcattt   2820

tgagcaggtc tcccttttac tcttcccaac tgggaacttg gagctggtac aaatacaatg   2880

cagagctcat tttcagttaa tattagtact ttttaaatct ttactctcta tcttgaagca   2940

ttagatgtta agactaatgt gtaaaaacca cgtctgagct tgcttttccc tctggacact   3000

ctgcttttga ttgcctatcc ctataagtgg ctcattttac tgtcttctga tcctggtggc   3060

cttatttttg ctatgttaag gttgtgtttt ttaatacttg gatttatttt catatactta   3120

cataaaccgt ggtgattgca cat                                           3143


<210>  3031
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  3031

Met Met Lys Ser Gln Gly Leu Val Ser Phe Lys Asp Val Ala Val Asp 
1               5                   10                  15


Phe Thr Gln Glu Glu Trp Gln Gln Leu Asp Pro Ser Gln Arg Thr Leu 
            20                  25                  30


Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser His Leu Val Ser Met Gly 
        35                  40                  45


Tyr Pro Val Ser Lys Pro Asp Val Ile Ser Lys Leu Glu Gln Gly Glu 
    50                  55                  60


Glu Pro Trp Ile Ile Lys Gly Asp Ile Ser Asn Trp Ile Tyr Pro Asp 
65                  70                  75                  80


Glu Tyr Gln Ala Asp Gly Arg Gln Gly Lys Lys Ser Asn Leu His Asn 
                85                  90                  95


Ser Gln Ser Cys Ile Leu Gly Thr Val Ser Phe His His Lys Ile Leu 
            100                 105                 110


Lys Gly Val Thr Arg Asp Gly Ser Leu Cys Ser Ile Leu Lys Val Cys 
        115                 120                 125


Gln Gly Asp Gly Gln Leu Gln Arg Phe Leu Glu Asn Gln Asp Lys Leu 
    130                 135                 140


Phe Arg Gln Val Thr Phe Val Asn Ser Lys Thr Val Thr Glu Ala Ser 
145                 150                 155                 160


Gly His Lys Tyr Asn Pro Leu Gly Lys Ile Phe Gln Glu Cys Ile Glu 
                165                 170                 175


Thr Asp Ile Ser Ile Gln Arg Phe His Lys Tyr Asp Ala Phe Lys Lys 
            180                 185                 190


Asn Leu Lys Pro Asn Ile Asp Leu Pro Ser Cys Tyr Lys Ser Asn Ser 
        195                 200                 205


Arg Lys Lys Pro Asp Gln Ser Phe Gly Gly Gly Lys Ser Ser Ser Gln 
    210                 215                 220


Ser Glu Pro Asn Ser Asn Leu Glu Lys Ile His Asn Gly Val Ile Pro 
225                 230                 235                 240


Phe Asp Asp Asn Gln Cys Gly Asn Val Phe Arg Asn Thr Gln Ser Leu 
                245                 250                 255


Ile Gln Tyr Gln Asn Val Glu Thr Lys Glu Lys Ser Cys Val Cys Val 
            260                 265                 270


Thr Cys Gly Lys Ala Phe Ala Lys Lys Ser Gln Leu Ile Val His Gln 
        275                 280                 285


Arg Ile His Thr Gly Lys Lys Pro Tyr Asp Cys Gly Ala Cys Gly Lys 
    290                 295                 300


Ala Phe Ser Glu Lys Phe His Leu Val Val His Gln Arg Thr His Thr 
305                 310                 315                 320


Gly Glu Lys Pro Tyr Asp Cys Ser Glu Cys Gly Lys Ala Phe Ser Gln 
                325                 330                 335


Lys Ser Ser Leu Ile Ile His Gln Arg Val His Thr Gly Glu Lys Pro 
            340                 345                 350


Tyr Glu Cys Ser Glu Cys Gly Lys Ala Phe Ser Gln Lys Ser Pro Leu 
        355                 360                 365


Ile Ile His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Arg 
    370                 375                 380


Glu Cys Gly Lys Ala Phe Ser Gln Lys Ser Gln Leu Ile Ile His His 
385                 390                 395                 400


Arg Ala His Thr Gly Glu Lys Pro Tyr Glu Cys Thr Glu Cys Gly Lys 
                405                 410                 415


Ala Phe Cys Glu Lys Ser His Leu Ile Ile His Lys Arg Ile His Thr 
            420                 425                 430


Gly Glu Lys Pro Tyr Lys Cys Ala Gln Cys Glu Glu Ala Phe Ser Arg 
        435                 440                 445


Lys Thr Glu Leu Ile Thr His Gln Leu Val His Thr Gly Glu Lys Pro 
    450                 455                 460


Tyr Glu Cys Thr Glu Cys Gly Lys Thr Phe Ser Arg Lys Ser Gln Leu 
465                 470                 475                 480


Ile Ile His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Ser 
                485                 490                 495


Glu Cys Gly Lys Ala Phe Cys Gln Lys Ser His Leu Ile Gly His Gln 
            500                 505                 510


Arg Ile His Thr Gly Glu Lys Pro Tyr Ile Cys Thr Glu Cys Gly Lys 
        515                 520                 525


Ala Phe Ser Gln Lys Ser His Leu Pro Gly His Gln Arg Ile His Thr 
    530                 535                 540


Gly Glu Lys Pro Tyr Ile Cys Ala Glu Cys Gly Lys Ala Phe Ser Gln 
545                 550                 555                 560


Lys Ser Asp Leu Val Leu His Gln Arg Ile His Thr Gly Glu Arg Pro 
                565                 570                 575


Tyr Gln Cys Ala Ile Cys Gly Lys Ala Phe Ile Gln Lys Ser Gln Leu 
            580                 585                 590


Thr Val His Gln Arg Ile His Thr Val Val Lys Ser 
        595                 600


<210>  3032
<211>  733
<212>  DNA
<213>  Homo sapiens

<400>  3032
acgaagacga ccgggctctc aagatggcgg ccccatgcgg aaacagctcc agggagcagc     60

catgttgctt cctgaacaaa gcctctgaag atgcggaacg ggcaaaaccg cccagtacgg    120

aacggcgcag cctcgggagc ccggtgtggt gctcgcggac aggaagcagg agagtttgcc    180

aatagggatg tgacagcggt tcccattaag cggtgatggt ggttttggga cctgataatc    240

gagctgggag tcagaggcgg gatgtgtgcg gtgaaggatg ttttgatacc cccatataaa    300

ataatctgtc tgtcatggga gcccccacgt cctctgaaat agttcagctc tgtctgcatg    360

acttgtcctg ggactgagga aaatttacca gtcatctggc cttttggaag agcaaaaaat    420

gatgaagtcc cagctttttt ctagctacaa tggcagagtt gagtagttac aacagaaacc    480

gtatggcctg caatgccaaa aatgtaaact ttactgaaaa agtttgttga cccctgcttt    540

caaggaacaa attgattaca gatgcttcct attgtccagc tttatccaca ggggttagta    600

tcattcaagg atgtggctgt ggatttcacc caggaggagt ggcagcaact tgacccttct    660

cagaggaccc tgtacaggga tgtgatgctg gagaactaca gccacctggt ctcaatgggg    720

tatccagttt cca                                                       733


<210>  3033
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  3033

Met Leu Pro Ile Val Gln Leu Tyr Pro Gln Gly Leu Val Ser Phe Lys 
1               5                   10                  15


Asp Val Ala Val Asp Phe Thr Gln Glu Glu Trp Gln Gln Leu Asp Pro 
            20                  25                  30


Ser Gln Arg Thr Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser His 
        35                  40                  45


Leu Val Ser Met Gly Tyr Pro Val 
    50                  55


<210>  3034
<211>  1127
<212>  DNA
<213>  Homo sapiens

<400>  3034
acgaagacga ccgggctctc aagatggcgg ccccatgcgg aaacagctcc agggagcagc     60

catgttgctt cctgaacaaa gcctctgaag atgcggaacg ggcaaaaccg cccagtacgg    120

aacggcgcag cctcgggagc ccggtgtggt gctcgcggac aggaagcagg agagtttgcc    180

aatagggatg tgacagcggt tcccattaag cggtgatggt ggttttggga cctgataatc    240

gagctgggag tcagaggcgg gatgtgtgcg gtgaaggatg ttttgatacc cccatataaa    300

ataatctgtc tgtcatggga gcccccacgt cctctgaaat agttcagctc tgtctgcatg    360

acttgtcctg ggactgagga aaatttacca ggtatttacc ttcctgcatt gtggtatact    420

cttttttttt ccagtggttc caacctatca ccatttttgt atacagacaa tagagctgtt    480

gaaaaagagc aataaaaatt taaacagaaa acatcttaaa attaaccttt gagttcatgc    540

acattgattt agcaagagtt ttctaagttg ggggaaaata taagagagtt cttggaaaat    600

tgttggaatt cagctgctgg ttctttttag gaatagggaa cacatgcctc agttttccat    660

ttggtcattc ccattcttac tgccaaggag ctccatcttc acttatatcc ttatatagct    720

atccatgatt attgcctcat gaaaatcttc tataaataga attgctgatt cccaagggga    780

acagtaagtt gttagtaaat caactggaaa catatcttca catctatcca attataaaac    840

cttggtcaac ttctatgtga tcatattata ggtacaagag gagtaaagaa tgatccctcc    900

tccacatggt gcctgctgag acttctgtaa ggctcaaaca accttatccc acagggtagc    960

ccattagtta cttgacttct gatgttagtt gttgcaagat tggtgaatgt gaaagctgca   1020

gtctgggttt ggactatgaa aaacattctg atcaccagtt ttgctttttc agtcatctgg   1080

ccttttggaa gagcaaaaaa tgatgaagtc ccaggtgagt tgctttt                 1127


<210>  3035
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  3035

Met Ala Ala Pro Cys Gly Asn Ser Ser Arg Glu Gln Pro Cys Cys Phe 
1               5                   10                  15


Leu Asn Lys Ala Ser Glu Asp Ala Glu Arg Ala Lys Pro Pro Ser Thr 
            20                  25                  30


Glu Arg Arg Ser Leu Gly Ser Pro Val Trp Cys Ser Arg Thr Gly Ser 
        35                  40                  45


Arg Arg Val Cys Gln 
    50


<210>  3036
<211>  1156
<212>  DNA
<213>  Homo sapiens

<400>  3036
atgatacact gtgaagctac tcattgtgga aagattctta gcaataaaca atctcttatt     60

cattatgtga atgttgaaac tggggagaag acctatgtat gtgttgaatg tggaaaatcc    120

tttctcaaga agtcacagat tattatacat caaagaattc atactggaga gaaaccttat    180

gattgtggtg catgtggaaa agccttcagt gagaagtcac accttattgc acatcagaga    240

actcatactg gggagaaacc ttatgattgt tctgaatgtg gaaaaggctt ttctcagaaa    300

tcatccctca ttatacatca gagagttcac actggggaaa aaccatatga atgtagtgaa    360

tgtgagaaag ccttctccca gaaatcaccc ctcattatac atcagagaat acatactggg    420

gaaaagccct atgaatgtag agtagttcac actggtgaga aaccctacaa atgtgctcaa    480

tgtgaggaag ccttcagcag gaagtcagaa ctcattatac atcagataat tcatactggg    540

gagaaaccgt atgaatgtac agaatgtggg aaaacattct ctcgcaagtc acaactcatc    600

atacatcaga gaacccacac tggagagaaa ccctataaat gtaccaaatg tggaaaatcc    660

ttctgtcagc agtcacatct cattggacat cagagaattc acacgggaga acaaccttat    720

ataattcata ctggagagaa acctgatcga tgtactgtat gtgggaaggc cttcatccag    780

aagtcccaac tcactgtaca tcagagaatt catacactaa tgaaatcata agaatggtct    840

gaacacagaa aagccttcag ggtcagttca agccttaata gatagtgcaa caaccaatgg    900

atttgatgat tttggggact acatctttgt tgataaaatt ttacaagtga agtcatgttc    960

ctaatgtatt tcattcttta tcaaagataa tagagaagtc aatacgtaaa tgatggacat   1020

tttcactatg gcatataaaa gtttttaaat tgagaaatga atgattagca taacagaacg   1080

aattgcatgt acatctcttt tgaagttatg tgctcctgat tatactacat aacaatcaga   1140

tatgtgtaag attgtt                                                   1156


<210>  3037
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  3037

Met Ile His Cys Glu Ala Thr His Cys Gly Lys Ile Leu Ser Asn Lys 
1               5                   10                  15


Gln Ser Leu Ile His Tyr Val Asn Val Glu Thr Gly Glu Lys Thr Tyr 
            20                  25                  30


Val Cys Val Glu Cys Gly Lys Ser Phe Leu Lys Lys Ser Gln Ile Ile 
        35                  40                  45


Ile His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Asp Cys Gly Ala 
    50                  55                  60


Cys Gly Lys Ala Phe Ser Glu Lys Ser His Leu Ile Ala His Gln Arg 
65                  70                  75                  80


Thr His Thr Gly Glu Lys Pro Tyr Asp Cys Ser Glu Cys Gly Lys Gly 
                85                  90                  95


Phe Ser Gln Lys Ser Ser Leu Ile Ile His Gln Arg Val His Thr Gly 
            100                 105                 110


Glu Lys Pro Tyr Glu Cys Ser Glu Cys Glu Lys Ala Phe Ser Gln Lys 
        115                 120                 125


Ser Pro Leu Ile Ile His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr 
    130                 135                 140


Glu Cys Arg Val Val His Thr Gly Glu Lys Pro Tyr Lys Cys Ala Gln 
145                 150                 155                 160


Cys Glu Glu Ala Phe Ser Arg Lys Ser Glu Leu Ile Ile His Gln Ile 
                165                 170                 175


Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Thr Glu Cys Gly Lys Thr 
            180                 185                 190


Phe Ser Arg Lys Ser Gln Leu Ile Ile His Gln Arg Thr His Thr Gly 
        195                 200                 205


Glu Lys Pro Tyr Lys Cys Thr Lys Cys Gly Lys Ser Phe Cys Gln Gln 
    210                 215                 220


Ser His Leu Ile Gly His Gln Arg Ile His Thr Gly Glu Gln Pro Tyr 
225                 230                 235                 240


Ile Ile His Thr Gly Glu Lys Pro Asp Arg Cys Thr Val Cys Gly Lys 
                245                 250                 255


Ala Phe Ile Gln Lys Ser Gln Leu Thr Val His Gln Arg Ile His Thr 
            260                 265                 270


Leu Met Lys Ser 
        275


<210>  3038
<211>  3583
<212>  DNA
<213>  Homo sapiens

<400>  3038
ccgcttgtac tgagacgcct gggatctcaa aatggcggcc ccgtgcggaa acagcgtctg     60

ggagcagtca tgttgcctcc tgaacaaagc cgctgaagat gaagaatggg caaaatcgcc    120

ccatacggaa cagcgcagcc tcgggagccc gttacctggc tcgcgaacac gaagcgggag    180

agttcgccaa tatggatgtg acagcggttc ccattaagcg gtgataggat ttttgggacc    240

tgataatcaa gctagggacc ctgggatggc acaaatgaaa caatctctct atcatgatat    300

tcccccgttg ctctgaatga gttcagctct gtctgcatga tctatcccag actgaaaaga    360

gtttaccagc taagtacttt cctgcaatgt agtatattcc cgtttattgt tccaacctgt    420

cagtaatttt ttatacaggc aactgccttg ttgaaaatca gcaataaaaa tttaaaccaa    480

agaaatctta aaatcagcaa taaaaattta aaccaaagaa atcttaaaat cagcaatttt    540

aatccacaaa tattgattta tcaagagaat ttgctggttt ggagtaaaat ataaaagagc    600

ttgtcttact cagtttgggc tgctgtaaca gaatgccaca gatggaggac cttaaacagc    660

aaacatttat ttctcacatt tctggaggca gagaagttca agatcaaggt gccagcaggt    720

ctagtgtttg ctgatagcac tcttcctgtt ttgtaaactt ctcattgtat cctcacaagg    780

ccaagagaca aatcatctct ctgatatttc ctgttgtaag ggcattaatc ccatttatta    840

gggctctcat ttcatgacct aattacctcc caaagacccc acttcccaat acaatcacat    900

tagaattgca acatttgaat tttggaggga caaacattca gtccataaca gagctcttag    960

aattttgtag gctgctttgg tttaggaaat aagggaatac actccttaat tttcctcttg   1020

gtcactccca ttcttgtctc cagggaacat ctgcagttaa atatatattt ctccatgata   1080

tccatgatta ttgtcttaag atagttctac aaatagaaat tcaaatagaa ttgctggttc   1140

aaaggggaac aattaggtgt ttgtaaatcc acaggaaaca tatctgcatt tatctaatta   1200

aaaatacacc ttgccctatg tgatcaaatt atacacctag ttctgtatga tcatatcata   1260

gtcacaaaag gactaaaggt ggatacctcc ttcacatggt gtttgctata agggtcaaac   1320

gaccttctcc catcacgacc ttctcccaca ggatggccta tcagctacct gacttctggt   1380

ggtggttgtt tagagactgg tgaatgttag ttctggccca taaaaactcc attctttctt   1440

ccagacctga ttcctcagac ctctgcccta tcggaaggga agcagaaaat gatcaggtct   1500

cagggtccag tgtcatttga ggatgtggct gtggatttca cccaggagga gtggcagcaa   1560

ctggactatg ctcagaggac cctgtacagg gatgtgatgc tggagatcta tagccacctg   1620

gtctcaatgg gatatccagt ttccaaacca gatgtcatct ccaagttgga acaaggagaa   1680

gagccatgga tcataaagag acacatacca aattggatct atccagacag agagagtaga   1740

cttgacaccc ctcaactgga tatatttaga gatgttttct tccataagga gacactggaa   1800

agtattacaa ggggtcattc attgtactcc attttaaaag tctggcaagg tgatgaccag   1860

ctggagagag atcaggaaaa ctgagacaaa tttgtcaggc aagttgtagt catcaacaac   1920

aaaagaatat ctgaagagtc aggtcatcca tataatatat ttggaaaaat atttcatgac   1980

tgcacagacc tagatacttc aaaacaaaga ctgtgtaagt gtgattcatt tgaaaagacc   2040

ttgaaaccaa atattaacct agtgagttat aataggaatt ttgcaagaaa aaacattgat   2100

gagaatttta gatgtgggaa aacacctagc tacagttctt gctattctaa gcatgaaaaa   2160

aatcatagtg gaatgataca ctgtgaagct actcattgtg gaaagattct tagcaataaa   2220

caatctctta ttcattatgt gaatgttgaa actggggaga agacctatgt atgtgttgaa   2280

tgtggaaaat cctttctcaa gaagtcacag attattatac atcaaagaat tcatactgga   2340

gagaaacctt atgattgtgg tgcatgtgga aaagccttca gtgagaagtc acaccttatt   2400

gcacatcaga gaactcatac tggggagaaa ccttatgatt gttctgaatg tggaaaaggc   2460

ttttctcaga aatcatccct cattatacat cagagagttc acactgggga aaaaccatat   2520

gaatgtagtg aatgtgagaa agccttctcc cagaaatcac ccctcattat acatcagaga   2580

atacatactg gggaaaagcc ctatgaatgt agagtgtggg aaagcctttt cccagagtca   2640

cagctgatta tacatcacag agctcatact ggagagaagc catgtaagtg tactgaatgt   2700

gggaaagcat tctgttttat acattaaaga gttcacactg gtgagaaacc ctacaaatgt   2760

gctcaatgtg aggaagcctt cagcaggaag tcagaactca ttatacatca gataattcat   2820

actggggaga aaccgtatga atgtacagaa tgtgggaaaa cattctctcg caagtcacaa   2880

ctcatcatac atcagagaac ccacactgga gagaaaccct ataaatgtac caaatgtgga   2940

aaatccttct gtcagcagtc acatctcatt ggacatcaga gaattcacac gggagaacaa   3000

ccttatgtat gttctgaatg tgggaaagcc ttctctcaga agtctcacct cccagggcat   3060

tggtgaattc atacaggaga gaaaccttac atatgtgctg aatgtggaaa ggccttttct   3120

cagaagtcag accttgttgt acatcagata attcatactg gagagaaacc tgatcgatgt   3180

actgtatgtg ggaaggcctt catccagaag tcccaactca ctgtacatca gagaattcat   3240

acactaatga aatcataaga atggtctgaa cacagaaaag ccttcagggt cagttcaagc   3300

cttaatagat agtgcaacaa ccaatggatt tgatgatttt ggggactaca tctttgttga   3360

taaaatttta caagtgaagt catgttccta atgtatttca ttctttatca aagataatag   3420

agaagtcaat acgtaaatga tggacatttt cactatggca tataaaagtt tttaaattga   3480

gaaatgaatg attagcataa cagaacgaat tgcatgtaca tctcttttga agttatgtgc   3540

tcctgattat actacataac aatcagatat gtgtaagatt gtt                     3583


<210>  3039
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  3039

Met Ile Arg Ser Gln Gly Pro Val Ser Phe Glu Asp Val Ala Val Asp 
1               5                   10                  15


Phe Thr Gln Glu Glu Trp Gln Gln Leu Asp Tyr Ala Gln Arg Thr Leu 
            20                  25                  30


Tyr Arg Asp Val Met Leu Glu Ile Tyr Ser His Leu Val Ser Met Gly 
        35                  40                  45


Tyr Pro Val Ser Lys Pro Asp Val Ile Ser Lys Leu Glu Gln Gly Glu 
    50                  55                  60


Glu Pro Trp Ile Ile Lys Arg His Ile Pro Asn Trp Ile Tyr Pro Asp 
65                  70                  75                  80


Arg Glu Ser Arg Leu Asp Thr Pro Gln Leu Asp Ile Phe Arg Asp Val 
                85                  90                  95


Phe Phe His Lys Glu Thr Leu Glu Ser Ile Thr Arg Gly His Ser Leu 
            100                 105                 110


Tyr Ser Ile Leu Lys Val Trp Gln Gly Asp Asp Gln Leu Glu Arg Asp 
        115                 120                 125


Gln Glu Asn 
    130


<210>  3040
<211>  3240
<212>  DNA
<213>  Homo sapiens

<400>  3040
agtcctccgc ttgtactgag acgcctggga tctcaaaatg gcggccccgt gcggaaacag     60

cgtctgggag cagtcatgtt gcctcctgaa caaagccgct gaagatgaag aatgggcaaa    120

atcgccccat acggaacagc gcagcctcgg gagcccgtta cctggctcgc gaacacgaag    180

cgggagagtt cgccaatatg gatgtgacag cggttcccat taagcggtga taggattttt    240

gggacctgat aatcaagcta gggaccctgg gatggcacaa atgaaacaat ctctctatca    300

tgatattccc ccgttgctct gaatgagttc agctctgtct gcatgatcta tcccagactg    360

aaaagagttt accagctaag tactttcctg caatgtagta tattcccgtt tattgttcca    420

acctgtcagt aattttttat acaggcaact gccttgttga aaatcagcaa taaaaattta    480

aaccaaagaa atcttaaaat cagcaataaa aatttaaacc aaagaaatct taaaatcagc    540

aattttaatc cacaaatatt gatttatcaa gagaatttgc tggtttggag taaaatataa    600

aagagctgag ctcttagaat tttgtaggct gctttggttt aggaaataag ggaatacact    660

ccttaatttt cctcttggtc actcccattc ttgtctccag ggaacatctg cagttaaata    720

tatatttctc catgatatcc atgattattg tcttaagata gttctacaaa tagaaattca    780

aatagaattg ctggttcaaa ggggaacaat taggtgtttg taaatccaca ggaaacatat    840

ctgcatttat ctaattaaaa atacaccttg ccctatgtga tcaaattata cacctagttc    900

tgtatgatca tatcatagtc acaaaaggac taaaggtgga tacctccttc acatggtgtt    960

tgctataagg gtcaaacgac cttctcccat cacgaccttc tcccacagga tggcctatca   1020

gctacctgac ttctggtggt ggttgtttag agactggtga atgttagttc tggcccataa   1080

aaactccatt ctttcttcca gacctgattc ctcagacctc tgccctatcg gaagggaagc   1140

agaaaatgat caggtctcag ggtccagtgt catttgagga tgtggctgtg gatttcaccc   1200

aggaggagtg gcagcaactg gactatgctc agaggaccct gtacagggat gtgatgctgg   1260

agatctatag ccacctggtc tcaatgggat atccagtttc caaaccagat gtcatctcca   1320

agttggaaca aggagaagag ccatggatca taaagagaca cataccaaat tggatctatc   1380

cagacagaga gagtagactt gacacccctc aactggatat atttagagat gttttcttcc   1440

ataaggagac actggaaagt attacaaggg gtcattcatt gtactccatt ttaaaagtct   1500

ggcaaggtga tgaccagctg gagagagatc aggaaaactg agacaaattt gtcaggcaag   1560

ttgtagtcat caacaacaaa agaatatctg aagagtcagg tcatccatat aatatatttg   1620

gaaaaatatt tcatgactgc acagacctag atacttcaaa acaaagactg tgtaagtgtg   1680

attcatttga aaagaccttg aaaccaaata ttaacctagt gagttataat aggaattttg   1740

caagaaaaaa cattgatgag aattttagat gtgggaaaac acctagctac agttcttgct   1800

attctaagca tgaaaaaaat catagtggaa tgatacactg tgaagctact cattgtggaa   1860

agattcttag caataaacaa tctcttattc attatgtgaa tgttgaaact ggggagaaga   1920

cctatgtatg tgttgaatgt ggaaaatcct ttctcaagaa gtcacagatt attatacatc   1980

aaagaattca tactggagag aaaccttatg attgtggtgc atgtggaaaa gccttcagtg   2040

agaagtcaca ccttattgca catcagagaa ctcatactgg ggagaaacct tatgattgtt   2100

ctgaatgtgg aaaaggcttt tctcagaaat catccctcat tatacatcag agagttcaca   2160

ctggggaaaa accatatgaa tgtagtgaat gtgagaaagc cttctcccag aaatcacccc   2220

tcattataca tcagagaata catactgggg aaaagcccta tgaatgtaga gtgtgggaaa   2280

gccttttccc agagtcacag ctgattatac atcacagagc tcatactgga gagaagccat   2340

gtaagtgtac tgaatgtggg aaagcattct gttttataca ttaaagagtt cacactggtg   2400

agaaacccta caaatgtgct caatgtgagg aagccttcag caggaagtca gaactcatta   2460

tacatcagat aattcatact ggggagaaac cgtatgaatg tacagaatgt gggaaaacat   2520

tctctcgcaa gtcacaactc atcatacatc agagaaccca cactggagag aaaccctata   2580

aatgtaccaa atgtggaaaa tccttctgtc agcagtcaca tctcattgga catcagagaa   2640

ttcacacggg agaacaacct tatgtatgtt ctgaatgtgg gaaagccttc tctcagaagt   2700

ctcacctccc agggcattgg tgaattcata caggagagaa accttacata tgtgctgaat   2760

gtggaaaggc cttttctcag aagtcagacc ttgttgtaca tcagataatt catactggag   2820

agaaacctga tcgatgtact gtatgtggga aggccttcat ccagaagtcc caactcactg   2880

tacatcagag aattcataca ctaatgaaat cataagaatg gtctgaacac agaaaagcct   2940

tcagggtcag ttcaagcctt aatagatagt gcaacaacca atggatttga tgattttggg   3000

gactacatct ttgttgataa aattttacaa gtgaagtcat gttcctaatg tatttcattc   3060

tttatcaaag ataatagaga agtcaatacg taaatgatgg acattttcac tatggcatat   3120

aaaagttttt aaattgagaa atgaatgatt agcataacag aacgaattgc atgtacatct   3180

cttttgaagt tatgtgctcc tgattatact acataacaat cagatatgtg taagattgtt   3240


<210>  3041
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  3041

Met Ile Arg Ser Gln Gly Pro Val Ser Phe Glu Asp Val Ala Val Asp 
1               5                   10                  15


Phe Thr Gln Glu Glu Trp Gln Gln Leu Asp Tyr Ala Gln Arg Thr Leu 
            20                  25                  30


Tyr Arg Asp Val Met Leu Glu Ile Tyr Ser His Leu Val Ser Met Gly 
        35                  40                  45


Tyr Pro Val Ser Lys Pro Asp Val Ile Ser Lys Leu Glu Gln Gly Glu 
    50                  55                  60


Glu Pro Trp Ile Ile Lys Arg His Ile Pro Asn Trp Ile Tyr Pro Asp 
65                  70                  75                  80


Arg Glu Ser Arg Leu Asp Thr Pro Gln Leu Asp Ile Phe Arg Asp Val 
                85                  90                  95


Phe Phe His Lys Glu Thr Leu Glu Ser Ile Thr Arg Gly His Ser Leu 
            100                 105                 110


Tyr Ser Ile Leu Lys Val Trp Gln Gly Asp Asp Gln Leu Glu Arg Asp 
        115                 120                 125


Gln Glu Asn 
    130


<210>  3042
<211>  2413
<212>  DNA
<213>  Homo sapiens

<400>  3042
agcgcctggc gagtcctccg cttgtactga gacgcctggg atctcaaaat ggcggccccg     60

tgcggaaaca gcgtctggga gcagtcatgt tgcctcctga acaaagccgc tgaagatgaa    120

gaatgggcaa aatcgcccca tacggaacag cgcagcctcg ggagcccgtt acctggctcg    180

cgaacacgaa gcgggagagt tcgccaatat ggatgtgaca gcggttccca ttaagcggtg    240

ataggatttt tgggacctga taatcaagct agggacctga ttcctcagac ctctgcccta    300

tcggaaggga agcagaaaat gatcaggtct cagggtccag tgtcatttga ggatgtggct    360

gtggatttca cccaggagga gtggcagcaa ctggactatg ctcagaggac cctgtacagg    420

gatgtgatgc tggagatcta tagccacctg gtctcaatgg gatatccagt ttccaaacca    480

gatgtcatct ccaagttgga acaaggagaa gagccatgga tcataaagag acacatacca    540

aattggatct atccagacag agagagtaga cttgacaccc ctcaactgga tatatttaga    600

gatgttttct tccataagga gacactggaa agtattacaa ggggtcattc attgtactcc    660

attttaaaag tctggcaagg tgatgaccag ctggagagag atcaggaaaa ctgagacaaa    720

tttgtcaggc aagttgtagt catcaacaac aaaagaatat ctgaagagtc aggtcatcca    780

tataatatat ttggaaaaat atttcatgac tgcacagacc tagatacttc aaaacaaaga    840

ctgtgtaagt gtgattcatt tgaaaagacc ttgaaaccaa atattaacct agtgagttat    900

aataggaatt ttgcaagaaa aaacattgat gagaatttta gatgtgggaa aacacctagc    960

tacagttctt gctattctaa gcatgaaaaa aatcatagtg gaatgataca ctgtgaagct   1020

actcattgtg gaaagattct tagcaataaa caatctctta ttcattatgt gaatgttgaa   1080

actggggaga agacctatgt atgtgttgaa tgtggaaaat cctttctcaa gaagtcacag   1140

attattatac atcaaagaat tcatactgga gagaaacctt atgattgtgg tgcatgtgga   1200

aaagccttca gtgagaagtc acaccttatt gcacatcaga gaactcatac tggggagaaa   1260

ccttatgatt gttctgaatg tggaaaaggc ttttctcaga aatcatccct cattatacat   1320

cagagagttc acactgggga aaaaccatat gaatgtagtg aatgtgagaa agccttctcc   1380

cagaaatcac ccctcattat acatcagaga atacatactg gggaaaagcc ctatgaatgt   1440

agagtgtggg aaagcctttt cccagagtca cagctgatta tacatcacag agctcatact   1500

ggagagaagc catgtaagtg tactgaatgt gggaaagcat tctgttttat acattaaaga   1560

gttcacactg gtgagaaacc ctacaaatgt gctcaatgtg aggaagcctt cagcaggaag   1620

tcagaactca ttatacatca gataattcat actggggaga aaccgtatga atgtacagaa   1680

tgtgggaaaa cattctctcg caagtcacaa ctcatcatac atcagagaac ccacactgga   1740

gagaaaccct ataaatgtac caaatgtgga aaatccttct gtcagcagtc acatctcatt   1800

ggacatcaga gaattcacac gggagaacaa ccttatgtat gttctgaatg tgggaaagcc   1860

ttctctcaga agtctcacct cccagggcat tggtgaattc atacaggaga gaaaccttac   1920

atatgtgctg aatgtggaaa ggccttttct cagaagtcag accttgttgt acatcagata   1980

attcatactg gagagaaacc tgatcgatgt actgtatgtg ggaaggcctt catccagaag   2040

tcccaactca ctgtacatca gagaattcat acactaatga aatcataaga atggtctgaa   2100

cacagaaaag ccttcagggt cagttcaagc cttaatagat agtgcaacaa ccaatggatt   2160

tgatgatttt ggggactaca tctttgttga taaaatttta caagtgaagt catgttccta   2220

atgtatttca ttctttatca aagataatag agaagtcaat acgtaaatga tggacatttt   2280

cactatggca tataaaagtt tttaaattga gaaatgaatg attagcataa cagaacgaat   2340

tgcatgtaca tctcttttga agttatgtgc tcctgattat actacataac aatcagatat   2400

gtgtaagatt gtt                                                      2413


<210>  3043
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  3043

Met Ile Arg Ser Gln Gly Pro Val Ser Phe Glu Asp Val Ala Val Asp 
1               5                   10                  15


Phe Thr Gln Glu Glu Trp Gln Gln Leu Asp Tyr Ala Gln Arg Thr Leu 
            20                  25                  30


Tyr Arg Asp Val Met Leu Glu Ile Tyr Ser His Leu Val Ser Met Gly 
        35                  40                  45


Tyr Pro Val Ser Lys Pro Asp Val Ile Ser Lys Leu Glu Gln Gly Glu 
    50                  55                  60


Glu Pro Trp Ile Ile Lys Arg His Ile Pro Asn Trp Ile Tyr Pro Asp 
65                  70                  75                  80


Arg Glu Ser Arg Leu Asp Thr Pro Gln Leu Asp Ile Phe Arg Asp Val 
                85                  90                  95


Phe Phe His Lys Glu Thr Leu Glu Ser Ile Thr Arg Gly His Ser Leu 
            100                 105                 110


Tyr Ser Ile Leu Lys Val Trp Gln Gly Asp Asp Gln Leu Glu Arg Asp 
        115                 120                 125


Gln Glu Asn 
    130


<210>  3044
<211>  2314
<212>  DNA
<213>  Homo sapiens

<400>  3044
ggctcagcgc ctggcgagtc ctccgcttgt actgagacgc ctgggatctc aaaatggcgg     60

ccccgtgcgg aaacagcgtc tgggagcagt catgttgcct cctgaacaaa gccgctgaag    120

atgaagaatg ggcaaaatcg ccccatacgg aacagcgcag cctcgggagc ccgttacctg    180

gctcgcgaac acgaagcggg agagttcgcc aatatggatg tgacagcggt tcccattaag    240

cggtgatagg atttttggga cctgataatc aagctaggga cctgattcct cagacctctg    300

ccctatcgga agggaagcag aaaatgatca ggtctcaggg tccagtgtca tttgaggatg    360

tggctgtgga tttcacccag gaggagtggc agcaactgga ctatgctcag aggaccctgt    420

acagggatgt gatgctggag atctatagcc acctggtctc aatgggatat ccagtttcca    480

aaccagatgt catctccaag ttggaacaag gagaagagcc atggatcata aagagacaca    540

taccaaattg gatctatcca gacagagaga gtagacttga cacccctcaa ctggatatat    600

ttagagatgt tttcttccat aaggagacac tggaaagtat tacaaggggt cattcattgt    660

actccatttt aaaagtctgg caaggtgatg accagctgga gagagatcag gaaaactgag    720

acaaatttgt caggcaagtt gtagtcatca acaacaaaag aatatctgaa gagtcaggtc    780

atccatataa tatatttgga aaaatatttc atgactgcac agacctagat acttcaaaac    840

aaagactgtg taagtgtgat tcatttgaaa agaccttgaa accaaatatt aacctagtga    900

gttataatag gaattttgca agaaaaaaca ttgatgagaa ttttagatgt gggaaaacac    960

ctagctacag ttcttgctat tctaagcatg aaaaaaatca tagtggaatg atacactgtg   1020

aagctactca ttgtggaaag attcttagca ataaacaatc tcttattcat tatgtgaatg   1080

ttgaaactgg ggagaagacc tatgtatgtg ttgaatgtgg aaaatccttt ctcaagaagt   1140

cacagattat tatacatcaa agaattcata ctggagagaa accttatgat tgtggtgcat   1200

gtggaaaagc cttcagtgag aagtcacacc ttattgcaca tcagagaact catactgggg   1260

agaaacctta tgattgttct gaatgtggaa aaggcttttc tcagaaatca tccctcatta   1320

tacatcagag agttcacact ggggaaaaac catatgaatg tagtgaatgt gagaaagcct   1380

tctcccagaa atcacccctc attatacatc agagaataca tactggggaa aagccctatg   1440

aatgtagagt gtgggaaagc cttttcccag agtcacagct gattatacat cacagagctc   1500

atactggaga gaagccatgt aagtgtactg aatgtgggaa agcattctgt tttatacatt   1560

aaagagttca cactggtgag aaaccctaca aatgtgctca atgtgaggaa gccttcagca   1620

ggaagtcaga actcattata catcagataa ttcatactgg ggagaaaccg tatgaatgta   1680

cagaatgtgg gaaaacattc tctcgcaagt cacaactcat catacatcag agaacccaca   1740

ctggagagaa accctataaa tgtaccaaat gtggaaaatc cttctgtcag cagtcacatc   1800

tcattggaca tcagagaatt cacacgggag aacaacctta tgtatgttct gaatgtggga   1860

aagccttctc tcagaagtct cacctcccag ggcattggtg aattcataca ggagagaaac   1920

cttacatatg tgctgaatgt ggaaaggcct tttctcagaa gtcagacctt gttgtacatc   1980

agataattca tactggagag aaacctgatc gatgtactgt atgtgggaag gccttcatcc   2040

agaagtccca actcactgta catcagagaa ttcatacact aatgaaatca taagaatggt   2100

ctgaacacag aaaagccttc agggtcagtt caagccttaa tagatagtgc aacaaccaat   2160

ggatttgatg attttgggga ctacatcttt gttgataaaa ttttacaagt gaagtcatgt   2220

tcctaatgta tttcattctt tatcaaagat aatagagaag tcaatacgta aatgatggac   2280

attttcacta tggcatataa aagtttttaa attg                               2314


<210>  3045
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  3045

Met Ile Arg Ser Gln Gly Pro Val Ser Phe Glu Asp Val Ala Val Asp 
1               5                   10                  15


Phe Thr Gln Glu Glu Trp Gln Gln Leu Asp Tyr Ala Gln Arg Thr Leu 
            20                  25                  30


Tyr Arg Asp Val Met Leu Glu Ile Tyr Ser His Leu Val Ser Met Gly 
        35                  40                  45


Tyr Pro Val Ser Lys Pro Asp Val Ile Ser Lys Leu Glu Gln Gly Glu 
    50                  55                  60


Glu Pro Trp Ile Ile Lys Arg His Ile Pro Asn Trp Ile Tyr Pro Asp 
65                  70                  75                  80


Arg Glu Ser Arg Leu Asp Thr Pro Gln Leu Asp Ile Phe Arg Asp Val 
                85                  90                  95


Phe Phe His Lys Glu Thr Leu Glu Ser Ile Thr Arg Gly His Ser Leu 
            100                 105                 110


Tyr Ser Ile Leu Lys Val Trp Gln Gly Asp Asp Gln Leu Glu Arg Asp 
        115                 120                 125


Gln Glu Asn 
    130


<210>  3046
<211>  863
<212>  DNA
<213>  Homo sapiens

<400>  3046
gtactgagac gcctgggatc tcaaaatggc ggccccgtgc ggaaacagcg tctgggagca     60

gtcatgttgc ctcctgaaca aagccgctga agatgaagaa tgggcaaaat cgccccatac    120

ggaacagcgc agcctcggga gcccgttacc tggctcgcga acacgaagcg ggagagttcg    180

ccaatatgga tgtgacagcg gttcccatta agcgacctga ttcctcagac ctctgcccta    240

tcggaaggga agcagaaaat gatcaggtct cagggtccag tgtcatttga ggatgtggct    300

gtggatttca cccaggagga gtggcagcaa ctggactatg ctcagaggac cctgtacagg    360

gatgtgatgc tggagatcta tagccacctg gtctcaatgg gatatccagt ttccaaacca    420

gatgtcatct ccaagttgga acaaggagaa gagccatgga tcataaagag acacatacca    480

aattggatct atccagacag agagagtaga cttgacaccc ctcaactgga tatatttaga    540

gatgttttct tccataagga gacactggaa agtattacaa ggggtcattc attgtactcc    600

attttaaaag tctggcaagg tgatgaccag ctggagagag atcaggaaaa ctgagacaaa    660

tttgtcaggc aagttgtagt catcaacaac aaaagaatat ctgaagagtc aggtcatcca    720

tataatatat ttggaaaaat atttcatgac tgcacagacc tagatacttc aaaacaaaga    780

ctgtgtaagt gtgattcatt tgaaaagacc ttgaaaccaa atattaacct agtgagttat    840

aataggaatt ttgcaagaaa aaa                                            863


<210>  3047
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  3047

Met Ile Arg Ser Gln Gly Pro Val Ser Phe Glu Asp Val Ala Val Asp 
1               5                   10                  15


Phe Thr Gln Glu Glu Trp Gln Gln Leu Asp Tyr Ala Gln Arg Thr Leu 
            20                  25                  30


Tyr Arg Asp Val Met Leu Glu Ile Tyr Ser His Leu Val Ser Met Gly 
        35                  40                  45


Tyr Pro Val Ser Lys Pro Asp Val Ile Ser Lys Leu Glu Gln Gly Glu 
    50                  55                  60


Glu Pro Trp Ile Ile Lys Arg His Ile Pro Asn Trp Ile Tyr Pro Asp 
65                  70                  75                  80


Arg Glu Ser Arg Leu Asp Thr Pro Gln Leu Asp Ile Phe Arg Asp Val 
                85                  90                  95


Phe Phe His Lys Glu Thr Leu Glu Ser Ile Thr Arg Gly His Ser Leu 
            100                 105                 110


Tyr Ser Ile Leu Lys Val Trp Gln Gly Asp Asp Gln Leu Glu Arg Asp 
        115                 120                 125


Gln Glu Asn 
    130


<210>  3048
<211>  1726
<212>  DNA
<213>  Homo sapiens

<400>  3048
tatcccagac tgaaaagagt ttaccagcta agtactttcc tgcaatgtag tatattcccg     60

tttattgttc caacctgtca gtaatttttt atacaggcaa ctgccttgtt gaaaatcagc    120

aataaaaatt taaaccaaag aaatcttaaa atcagcaata aaaatttaaa ccaaagaaat    180

cttaaaatca gcaattttaa tccacaaata ttgatttatc aagagaattt gctggtttgg    240

agtaaaatat aaaagagctt gtcttactca gtttgggctg ctgtaacaga atgccacaga    300

tggaggacct taaacagcaa acatttattt ctcacatttc tggaggcaga gaagttcaag    360

atcaaggtgc cagcaggtct agtgtttgct gatagcactc ttcctgtttt gtaaacttct    420

cattgtatcc tcacaaggcc aagagacaaa tcatctctct gatatttcct gttgtaaggg    480

cattaatccc atttattagg gctctcattt catgacctaa ttacctccca aagaccccac    540

ttcccaatac aatcacatta gaattgcaac atttgaattt tggagggaca aacattcagt    600

ccataacaga gctcttagaa ttttgtaggc tgctttggtt taggaaataa gggaatacac    660

tccttaattt tcctcttggt cactcccatt cttgtctcca gggaacatct gcagttaaat    720

atatatttct ccatgatatc catgattatt gtcttaagat agttctacaa atagaaattc    780

aaatagaatt gctggttcaa aggggaacaa ttaggtgttt gtaaatccac aggaaacata    840

tctgcattta tctaattaaa aatacacctt gccctatgtg atcaaattat acacctagtt    900

ctgtatgatc atatcatagt cacaaaagga ctaaaggtgg atacctcctt cacatggtgt    960

ttgctataag ggtcaaacga ccttctccca tcacgacctt ctcccacagg atggcctatc   1020

agctacctga cttctggtgg tggttgttta gagactggtg aatgttagtt ctggcccata   1080

aaaactccat tctttcttcc agacctgatt cctcagacct ctgccctatc ggaagggaag   1140

cagaaaatga tcaggtctca gggtccagtg tcatttgagg atgtggctgt ggatttcacc   1200

caggaggagt ggcagcaact ggactatgct cagaggaccc tgtacaggga tgtgatgctg   1260

gagatctata gccacctggt ctcaatggga tatccagttt ccaaaccaga tgtcatctcc   1320

aagttggaac aaggagaaga gccatggatc ataaagagac acataccaaa ttggatctat   1380

ccaggtgaaa atgtggcaga tgggagacaa gaaaaataaa tgctcagttg ctttatttta   1440

tttttaactg gcttatggct gaggcttaga tctccaccca gattgccatc tcctatttct   1500

tcttgctcct gtggagagca tgtagtaggc attcaacaac taactcatta atagtgagcc   1560

atgtacaaaa agaggtattt attttttgtt cactcaacaa tcataacttt agtgtcttcc   1620

taaaagaaat tcaaaggcaa tagaaacaaa tgcctttcag ggacataggt tgtacaagaa   1680

aaggtaagtc atcatgattc atggctgcat aaaattacat gtcaaa                  1726


<210>  3049
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  3049

Met Ile Arg Ser Gln Gly Pro Val Ser Phe Glu Asp Val Ala Val Asp 
1               5                   10                  15


Phe Thr Gln Glu Glu Trp Gln Gln Leu Asp Tyr Ala Gln Arg Thr Leu 
            20                  25                  30


Tyr Arg Asp Val Met Leu Glu Ile Tyr Ser His Leu Val Ser Met Gly 
        35                  40                  45


Tyr Pro Val Ser Lys Pro Asp Val Ile Ser Lys Leu Glu Gln Gly Glu 
    50                  55                  60


Glu Pro Trp Ile Ile Lys Arg His Ile Pro Asn Trp Ile Tyr Pro Gly 
65                  70                  75                  80


Glu Asn Val Ala Asp Gly Arg Gln Glu Lys 
                85                  90


<210>  3050
<211>  974
<212>  DNA
<213>  Homo sapiens

<400>  3050
ctgggatctc aaaatggcgg ccccgtgcgg aaacagcgtc tgggagcagt catgttgcct     60

cctgaacaaa gccgctgaag atgaagaatg ggcaaaatcg ccccatacgg aacagcgcag    120

cctcgggagc ccgttacctg gctcgcgaac acgaagcggg agagttcgcc aatatggatg    180

tgacagcggt tcccattaag cggtgatagg atttttggga cctgataatc aagctaggga    240

ccctgggatg gcacaaatga aacaatctct ctatcatgat attcccccgt tgctctgaat    300

gagttcagct ctgtctgcat gatctatccc agactgaaaa gagtttacca acctgattcc    360

tcagacctct gccctatcgg aagggaagca gaaaatgatc aggtctcagg gtccagtgtc    420

atttgaggat gtggctgtgg atttcaccca ggaggagtgg cagcaactgg actatgctca    480

gaggaccctg tacagggatg tgatgctgga gatctatagc cacctggtct caatgggata    540

tccagtttcc aaaccagatg tcatctccaa gttggaacaa ggagaagagc catggatcat    600

aaagagacac ataccaaatt ggatctatcc aggtgaaaat gtggcagatg ggagacaaga    660

aaaataaatg ctcagttgct ttattttatt tttaactggc ttatggctga ggcttagatc    720

tccacccaga ttgccatctc ctatttcttc ttgctcctgt ggagagcatg tagtaggcat    780

tcaacaacta actcattaat agtgagccat gtacaaaaag aggtatttat tttttgttca    840

ctcaacaatc ataactttag tgtcttccta aaagaaattc aaaggcaata gaaacaaatg    900

cctttcaggg acataggttg tacaagaaaa ggtaagtcat catgattcat ggctgcataa    960

aattacatgt caaa                                                      974


<210>  3051
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  3051

Met Ile Arg Ser Gln Gly Pro Val Ser Phe Glu Asp Val Ala Val Asp 
1               5                   10                  15


Phe Thr Gln Glu Glu Trp Gln Gln Leu Asp Tyr Ala Gln Arg Thr Leu 
            20                  25                  30


Tyr Arg Asp Val Met Leu Glu Ile Tyr Ser His Leu Val Ser Met Gly 
        35                  40                  45


Tyr Pro Val Ser Lys Pro Asp Val Ile Ser Lys Leu Glu Gln Gly Glu 
    50                  55                  60


Glu Pro Trp Ile Ile Lys Arg His Ile Pro Asn Trp Ile Tyr Pro Gly 
65                  70                  75                  80


Glu Asn Val Ala Asp Gly Arg Gln Glu Lys 
                85                  90


<210>  3052
<211>  577
<212>  DNA
<213>  Homo sapiens

<400>  3052
attaaggacg cgcgttccag tgttgtgcca cggtagctgg tttcttaacc tctctgacca     60

tcagttttct tctctgtaaa aaagggataa agctgaaggt tcaaacaagt ggtggaagga    120

gtatggaaat taatcttgtg gaagtggttc tctgtgtgag aaacatcggc ctgaccacct    180

gactttctga tcacattcca ctgggaaaaa gtccaaggaa catccctatc acattctgct    240

ggaacaagga ccaagtcacc tcatcatggg aacatcttat caatagcctg ttgggcagca    300

agccatactg cccagacccc tccctcccat acctacctga ttcctcagac ctctgcccta    360

tcggaaggga agcagaaaat gatcaggtct cagggtccag tgtcatttga ggatgtggct    420

gtggatttca cccaggagga gtggcagcaa ctggactatg ctcagaggac cctgtacagg    480

gatgtgatgc tggagatcta tagccacctg gtctcaatgg gatatccagt ttccaaacca    540

gatgtcatct ccaagttgga acaaggagaa gagccat                             577


<210>  3053
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  3053

Met Ile Arg Ser Gln Gly Pro Val Ser Phe Glu Asp Val Ala Val Asp 
1               5                   10                  15


Phe Thr Gln Glu Glu Trp Gln Gln Leu Asp Tyr Ala Gln Arg Thr Leu 
            20                  25                  30


Tyr Arg Asp Val Met Leu Glu Ile Tyr Ser His Leu Val Ser Met Gly 
        35                  40                  45


Tyr Pro Val Ser Lys Pro Asp Val Ile Ser Lys Leu Glu Gln Gly Glu 
    50                  55                  60


Glu 
65


<210>  3054
<211>  1384
<212>  DNA
<213>  Homo sapiens

<400>  3054
gaacaaagcc gctgaagatg aagaatgggc aaaatcgccc catacggaac agcgcagcct     60

cgggagcccg ttacctggct cgcgaacacg aagcgggaga gttcgccaat atggatgtga    120

cagcggttcc cattaagcgg tgataggatt tttgggacct gataatcaag ctaggggtca    180

cagactactc tcaagttgaa aaccttcaga agttttctca aaccacttgt cccctccata    240

actcgtgcct tcacagaaga aaacatcctt caaataaata tcaaaacaaa tattaaagga    300

atgggatcat tattgtcaat tctttctagc ccaaataaac caggaatacc ctgtggttga    360

ataagttagg aagctgagtt aggatgaatc agttcagccc tgtcaccaca gggaactgtt    420

gggaccctgg gatggcacaa atgaaacaat ctctctatca tgatattccc ccgttgctct    480

gaatgagttc agctctgtct gcatgatcta tcccagactg aaaagagttt accagctaag    540

tactttcctg caatgtagta tattcccgtt tattgttcca acctgtcagt aattttttat    600

acaggcaact gccttgttga aaatcagcaa taaaaattta aaccaaagaa atcttaaaat    660

cagcaataaa aatttaaacc aaagaaatct taaaatcagc aattttaatc cacaaatatt    720

gatttatcaa gagaatttgc tggtttggag taaaatataa aagagcttgt cttactcagt    780

ttgggctgct gtaacagaat gccacagatg gaggacctta aacagcaaac atttatttct    840

cacatttctg gaggcagaga agttcaagat caaggtgcca gcaggtctag tgtttgctga    900

tagcactctt cctgttttgt aaacttctca ttgtatcctc acaaggccaa gagacaaatc    960

atctctctga tatttcctgt tgtaagggca ttaatcccat ttattagggc tctcatttca   1020

tgacctaatt acctcccaaa gaccccactt cccaatacaa tcacattaga attgcaacat   1080

ttgaattttg gagggacaaa cattcagtcc ataacagagc tcttagaatt ttgtaggctg   1140

ctttggttta ggaaataagg gaatacactc cttaattttc ctcttggtca ctcccattct   1200

tgtctccagg gaacatctgc agttaaatat atatttctcc atgatatcca tgattattgt   1260

cttaagatag ttctacaaat agaaattcaa atagaattgc tggttcaaag gggaacaatt   1320

aggtgtttgt aaatccacag gaaacatatc tgcatttatc taattaaaaa tacaccttgc   1380

ccta                                                                1384


<210>  3055
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  3055

Met Asn Gln Phe Ser Pro Val Thr Thr Gly Asn Cys Trp Asp Pro Gly 
1               5                   10                  15


Met Ala Gln Met Lys Gln Ser Leu Tyr His Asp Ile Pro Pro Leu Leu 
            20                  25                  30


<210>  3056
<211>  626
<212>  DNA
<213>  Homo sapiens

<400>  3056
ctggaaagca gcaagcagca aaaattagac tgaggcctgc ttccagatcc tgagtagact     60

ccctctttgc agcccttttt ctcttattct ctctcctttg gccctgggct gacctctaga    120

tcctgatcaa actctctagc ctcttttttc tttctccccc tttctgggtg gctccggcaa    180

ggatcacccc cattgcagaa catcacgtcc aacgccgtct ccaattaatg ggcaaaggcc    240

caactaaaga aacctcccta tcctgtctta ctgggcaaag gcccaaggaa caccatgatg    300

acatcccacc agaaaaaggg tcaaaccacc ctatcatggg tacatcttat tgatatcctg    360

ccgggcagca agccacacta tccagacttc tcccagccat accttatcta ccaaagcaaa    420

cacgactgtc atactgaagc atggagaaga accatggaca ctggggggag aacctcaagg    480

tttggactat taatgaattg aaataatatg ccagaagaac cagaagctat catagctgaa    540

gatgtttcat tgtctaatga gataatgaaa aaattgagat aatgaaaata gtgagataat    600

aaaataatta aaataatgag ataatg                                         626


<210>  3057
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  3057

Met Met Thr Ser His Gln Lys Lys Gly Gln Thr Thr Leu Ser Trp Val 
1               5                   10                  15


His Leu Ile Asp Ile Leu Pro Gly Ser Lys Pro His Tyr Pro Asp Phe 
            20                  25                  30


Ser Gln Pro Tyr Leu Ile Tyr Gln Ser Lys His Asp Cys His Thr Glu 
        35                  40                  45


Ala Trp Arg Arg Thr Met Asp Thr Gly Gly Arg Thr Ser Arg Phe Gly 
    50                  55                  60


Leu Leu Met Asn 
65


<210>  3058
<211>  551
<212>  DNA
<213>  Homo sapiens

<400>  3058
agttacctag acaagcacca agtattagaa gccttagtgt ttcaatttgc catcaacttg     60

ctctgcaagc ccagaccaaa ccctgagctt ccctctggct ttctctttgg ttaaacaaga    120

agcctttatc ttcatctctc catcagaacc agtggcctgc tcctctctcc cttctctgct    180

ttcattgtcc accaacactg aagtcataaa tgactagagg gagctggagt gtgagggtcc    240

agaaacttgt atgatccaga atgccatgtc atacatccaa taaaattcaa ctctgcaagc    300

atgagagaga agaggaagga aaagagagaa tctgaagtgt gagtgattct gtttaccatt    360

ccacagacaa attttcaggc gggcagcatt ttcttcattc tatactccaa ggaagaggag    420

ggtcagagag gataaataac ctgcctcgga tctcagaata ggtaaatgac agagactcca    480

ctgcctctgt gatttctctc gaggccctgg gaccctcaga tggtgaaagg caagagtctg    540

cgaacccctg g                                                         551


<210>  3059
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  3059

Ser Val Ser Asp Ser Val Tyr His Ser Thr Asp Lys Phe Ser Gly Gly 
1               5                   10                  15


Gln His Phe Leu His Ser Ile Leu Gln Gly Arg Gly Gly Ser Glu Arg 
            20                  25                  30


Ile Asn Asn Leu Pro Arg Ile Ser Glu 
        35                  40


<210>  3060
<211>  568
<212>  DNA
<213>  Homo sapiens

<400>  3060
acacggctgg ggaaccgtgg ggcaggatgg agtgtgggtc cttcgtctct tggcttcctg     60

ggtgtcggag ctgggtgtaa atccaagcac ccaccctgca gcctgtgctc agcccaccgt    120

gctccaggct gctcaggctt tgtgcacgga gtagagtcag aggcaacgga agaggaggtg    180

gcagccagca ctcttgggcc cgggaccctt gcttgagact tgacatgaaa tggaagagag    240

tgcgagaact ggaaggagat cacagtagct ctggctttca gacacaagtg tctatttcct    300

cagtcaagga gaagccttcc tcacaccatg agaggtgtgg accttgtatc tcttacaaca    360

accaaggctg gacaccacct cctaatgtcg ttggaaaagc cagtgctcca ccttatgacc    420

caaactgact gagagaatgt ttgccaggcc cctggctgtc tacgaggaat gggagagacg    480

ggatttcacc gtgttagcca ggatagtctc aatctcctga cctcatgatc cacccgcctt    540

ggcctcccta agtgctggga ttacaggc                                       568


<210>  3061
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  3061

Met Lys Trp Lys Arg Val Arg Glu Leu Glu Gly Asp His Ser Ser Ser 
1               5                   10                  15


Gly Phe Gln Thr Gln Val Ser Ile Ser Ser Val Lys Glu Lys Pro Ser 
            20                  25                  30


Ser His His Glu Arg Cys Gly Pro Cys Ile Ser Tyr Asn Asn Gln Gly 
        35                  40                  45


Trp Thr Pro Pro Pro Asn Val Val Gly Lys Ala Ser Ala Pro Pro Tyr 
    50                  55                  60


Asp Pro Asn 
65


<210>  3062
<211>  571
<212>  DNA
<213>  Homo sapiens

<400>  3062
ctaaaatacc taaggtgact ccctgtggaa atattgatga cttgccctat gcattagaag     60

atcacgcagg ctcccagccc aaagggacta cagaacaatc ttgatcacat ccacccagca    120

acctggaaac agctttgaat ttcttgtcgt gttaacctct ggatctgaag agagggtaaa    180

cttaaaatta ccttcccatg gggacctggg actctggatg aatctacagt acaatgctgt    240

gaagaactga agagcctcag gcttagagac caggctaatg ttgagagtcc cagggcaaaa    300

tgcatggctc tgaatccttg cagagtctcc ctaggggcat ggagagggcc ctgacttggg    360

gctcgaggtc aggtggcagt gaagggcctc tacagcgata aagcccagct gcctctttac    420

ctttcctcat agtgaaaata catgggaaga aaaggagtgc tttgtccaac tctgttctag    480

cccatttcat ggtctggttg attcttttgg tagatgctga acactggaaa aatcctgcaa    540

ggattgaaga atgctactac taatagcagt g                                   571


<210>  3063
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  3063

Met His Gly Ser Glu Ser Leu Gln Ser Leu Pro Arg Gly Met Glu Arg 
1               5                   10                  15


Ala Leu Thr Trp Gly Ser Arg Ser Gly Gly Ser Glu Gly Pro Leu Gln 
            20                  25                  30


Arg 



<210>  3064
<211>  485
<212>  DNA
<213>  Homo sapiens

<400>  3064
ggcgcgcggt ggctgaggcg cttgcggcgg cggcggaaga ccccgtcggc gaaggtgtac     60

tcgctgttgg ggttgagcat ccagtagttg tccttgcccc agggccgcga ggggtcgcgc    120

agcaccttga cgaagcagtc gttgagcgaa aggttgtggc gcacggagtt gcgccagccc    180

gtgtagctgc cgcggaaaaa ggggaacttg cccatgagct atcagagaaa ccgagaatgt    240

atggagcagg gcgtgtctat ccacaacacc ctcaaggctg aatacagttg gggagaccag    300

acgctgccag acgtcacatg cattttttta aagtttccca gaagtgcttg gatatttctg    360

ccccttaatt cccattcctt ggggagtaca ttgatgggtt aataaaaaat gcctgcaggt    420

ggagcttgac caaacacttg taggtgactc cctgtggaaa tattgatgac ttgccctatg    480

catta                                                                485


<210>  3065
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  3065

Met Ser Tyr Gln Arg Asn Arg Glu Cys Met Glu Gln Gly Val Ser Ile 
1               5                   10                  15


His Asn Thr Leu Lys Ala Glu Tyr Ser Trp Gly Asp Gln Thr Leu Pro 
            20                  25                  30


Asp Val Thr Cys Ile Phe Leu Lys Phe Pro Arg Ser Ala Trp Ile Phe 
        35                  40                  45


Leu Pro Leu Asn Ser His Ser Leu Gly Ser Thr Leu Met Gly 
    50                  55                  60


<210>  3066
<211>  2321
<212>  DNA
<213>  Homo sapiens

<400>  3066
ctcaacgtcg aaccgaaggc gacacccacc caactcctcc ctctccgccc catagtccac     60

ccaacacttg cagcccctcc agagaaaaag cccagcggaa gaggactccg gaaaagtgac    120

tatctcggaa gaccagggta gagctcccgg gagaaaaagg cgaagatccc cggccccgga    180

tcgccatccc cttccctggc accagcttct ctaggctgcg cgaaggaaga gggtacgacg    240

ccggggaggg actgggtgcg cgggcatgaa gttggaggtg ttcgtccctc gcgcggccca    300

cggggacaag cagggcagtg acctggaggg cgcgggcggc agcgacgcgc cgtccccgct    360

gtcggcggcg ggagacgact ccctgggctc agatggggac tgcgcggcca acagcccggc    420

cgcgggcggc ggcgccagag atacgcaggg cgacggcgaa cagagtgcgg gaggcgggcc    480

gggcgcggag gaggcgatcc cggcagcagc tgctgcagcg gtggtggcgg agggcgcgga    540

ggccggggcg gcggggccag gcgcgggcgg cgcggggagc ggcgagggtg cacgcagcaa    600

gccatatacg cggcggccca agccccccta ctcgtacatc gcgctcatcg ccatggccat    660

ccgcgactcg gcgggcgggc gcttgacgct ggcggagatc aacgagtacc tcatgggcaa    720

gttccccttt ttccgcggca gctacacggg ctggcgcaac tccgtgcgcc acaacctttc    780

gctcaacgac tgcttcgtca aggtgctgcg cgacccctcg cggccctggg gcaaggacaa    840

ctactggatg ctcaacccca acagcgagta caccttcgcc gacggggtct tccgccgccg    900

ccgcaagcgc ctcagccacc gcgcgccggt ccccgcgccc gggctgcggc ccgaggaggc    960

cccgggcctc cccgccgccc cgccgcccgc gcccgccgcc ccggcctcgc cccgcatgcg   1020

ctcgcccgcc cgccaggagg agcgcgccag ccccgcgggc aagttctcca gctccttcgc   1080

catcgacagc atcctgcgca agcccttccg cagccgccgc ctcagggaca cggcccccgg   1140

gacgacgctt cagtggggcg ccgcgccctg cccgccgctg cccgcgttcc ccgcgctcct   1200

ccccgcggcg ccctgcaggg ccctgctgcc gctctgcgcg tacggcgcgg gcgagccggc   1260

gcggctgggc gcgcgcgagg ccgaggtgcc accgaccgcg ccgcccctcc tgcttgcacc   1320

tctcccggcg gcggcccccg ccaagccact ccgaggcccg gcggccggcg gcgcgcacct   1380

gtactgcccc ctgcggctgc ccgcagccct gcaggcggcc tcagtccgcc gccctggccc   1440

gcacctgccg tacccggtgg agacgctcct agcctgagta gcgccgcggg gcccgggaac   1500

gccgagtgcg cgccgtcggg gaggcgggaa cgcgggcccg cgcgcggact ttgcactttg   1560

aatccagagg aagatgaatt tttaaaatct ccatcaaacg tgccttaaag ctaaagcatt   1620

ttgacaggag tatttaaact tagtccagga tattttcctt tgtgttttat aactttacag   1680

aggaccaaag caattcttgt tttagtttct ttgcgaagcc tgctcctcct tcccttcata   1740

aggacttttt ttgtctttct ttaacgccca ggcttcgtct tatttctact gtttttgtcg   1800

caacttccat tgatttatgt cccttccctc ccccctaagt acatcaggga acctttccac   1860

actataaatg atatgactac tgtttggggt ttctgggccc ccatccgtgt acgtatgtgg   1920

catttccagg tatgactgag tgtgagagac atgtcagagg ctcttcagtg atttcttgct   1980

attgaccgat gcttcactgt gccaaaagag aaaaaaaatg ttgggttttg taattaaatt   2040

atttatatat ttttgaaacc cgaattgaaa atgttgcagg caacgggcta cagctttatt   2100

agtggttctc taactgtggt ctccttgggc caagcaattt ctttaaagga aaagttgatt   2160

atgtatgtgg ggtgccagga ccactgcctt gaaagcaagt gtgattttta tttttaatat   2220

tattttattt gtgtctgtgt acatattcat gtataaattt tatgaaaccc aagcatagtg   2280

cttatttttt aataaaacaa ctgacttaac acattgtgat g                       2321


<210>  3067
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  3067

Met Lys Leu Glu Val Phe Val Pro Arg Ala Ala His Gly Asp Lys Gln 
1               5                   10                  15


Gly Ser Asp Leu Glu Gly Ala Gly Gly Ser Asp Ala Pro Ser Pro Leu 
            20                  25                  30


Ser Ala Ala Gly Asp Asp Ser Leu Gly Ser Asp Gly Asp Cys Ala Ala 
        35                  40                  45


Asn Ser Pro Ala Ala Gly Gly Gly Ala Arg Asp Thr Gln Gly Asp Gly 
    50                  55                  60


Glu Gln Ser Ala Gly Gly Gly Pro Gly Ala Glu Glu Ala Ile Pro Ala 
65                  70                  75                  80


Ala Ala Ala Ala Ala Val Val Ala Glu Gly Ala Glu Ala Gly Ala Ala 
                85                  90                  95


Gly Pro Gly Ala Gly Gly Ala Gly Ser Gly Glu Gly Ala Arg Ser Lys 
            100                 105                 110


Pro Tyr Thr Arg Arg Pro Lys Pro Pro Tyr Ser Tyr Ile Ala Leu Ile 
        115                 120                 125


Ala Met Ala Ile Arg Asp Ser Ala Gly Gly Arg Leu Thr Leu Ala Glu 
    130                 135                 140


Ile Asn Glu Tyr Leu Met Gly Lys Phe Pro Phe Phe Arg Gly Ser Tyr 
145                 150                 155                 160


Thr Gly Trp Arg Asn Ser Val Arg His Asn Leu Ser Leu Asn Asp Cys 
                165                 170                 175


Phe Val Lys Val Leu Arg Asp Pro Ser Arg Pro Trp Gly Lys Asp Asn 
            180                 185                 190


Tyr Trp Met Leu Asn Pro Asn Ser Glu Tyr Thr Phe Ala Asp Gly Val 
        195                 200                 205


Phe Arg Arg Arg Arg Lys Arg Leu Ser His Arg Ala Pro Val Pro Ala 
    210                 215                 220


Pro Gly Leu Arg Pro Glu Glu Ala Pro Gly Leu Pro Ala Ala Pro Pro 
225                 230                 235                 240


Pro Ala Pro Ala Ala Pro Ala Ser Pro Arg Met Arg Ser Pro Ala Arg 
                245                 250                 255


Gln Glu Glu Arg Ala Ser Pro Ala Gly Lys Phe Ser Ser Ser Phe Ala 
            260                 265                 270


Ile Asp Ser Ile Leu Arg Lys Pro Phe Arg Ser Arg Arg Leu Arg Asp 
        275                 280                 285


Thr Ala Pro Gly Thr Thr Leu Gln Trp Gly Ala Ala Pro Cys Pro Pro 
    290                 295                 300


Leu Pro Ala Phe Pro Ala Leu Leu Pro Ala Ala Pro Cys Arg Ala Leu 
305                 310                 315                 320


Leu Pro Leu Cys Ala Tyr Gly Ala Gly Glu Pro Ala Arg Leu Gly Ala 
                325                 330                 335


Arg Glu Ala Glu Val Pro Pro Thr Ala Pro Pro Leu Leu Leu Ala Pro 
            340                 345                 350


Leu Pro Ala Ala Ala Pro Ala Lys Pro Leu Arg Gly Pro Ala Ala Gly 
        355                 360                 365


Gly Ala His Leu Tyr Cys Pro Leu Arg Leu Pro Ala Ala Leu Gln Ala 
    370                 375                 380


Ala Ser Val Arg Arg Pro Gly Pro His Leu Pro Tyr Pro Val Glu Thr 
385                 390                 395                 400


Leu Leu Ala 



<210>  3068
<211>  413
<212>  DNA
<213>  Homo sapiens

<400>  3068
tgggcacaga ggttgccaaa agggccagta ggaggagaag gcttcatgga ggacgggggc     60

aagagcgggc cgaccatgct ggcttcctcg ccttgtgtct ggctgactgc acaggcctga    120

ggaggctgtg tgtaagttgg caaatgacag gaagagcatg tgcttctaat cacccaccca    180

tcttaataac gtcgaacaga tacagtgcag aaactattgc acaaccacca gcatttcatt    240

acatcagaat ccttgccaat ttgaaagagg tccttgaatc cagggagagt tacatcttta    300

cgtttttgat cacgatcctc ttggaagata cttattaggg ccatttgttg atgacaatat    360

taagaattag caaatatctt cttaaatata acaaaaattg aattgtttca tta           413


<210>  3069
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  3069

Met Thr Gly Arg Ala Cys Ala Ser Asn His Pro Pro Ile Leu Ile Thr 
1               5                   10                  15


Ser Asn Arg Tyr Ser Ala Glu Thr Ile Ala Gln Pro Pro Ala Phe His 
            20                  25                  30


Tyr Ile Arg Ile Leu Ala Asn Leu Lys Glu Val Leu Glu Ser Arg Glu 
        35                  40                  45


Ser Tyr Ile Phe Thr Phe Leu Ile Thr Ile Leu Leu Glu Asp Thr Tyr 
    50                  55                  60


<210>  3070
<211>  703
<212>  DNA
<213>  Homo sapiens

<400>  3070
ttccagtcca gggatcaccg gtggagaccc attagtctat gccatcctag tcccacccgc     60

ctgacacctc atgctcacca gaaggacacc ttgggctgac cagagaggag ggtttctgtg    120

tgagaagcga tttgtgaatg catctcataa atgccctgct ctcagctgct gaacattctc    180

ctgctgaaag gcagggagct aattagcaca gccacctcga cagcgtctgt tccagtcacc    240

cctgcatgca tgctagaaca cctttgaaca atggatgaca gtctgcagag agcacagagc    300

tcccggagaa cataaaaatg caatggaaca gaatgaaggg atgcaagtca caatcgtctc    360

aactgcaagt tggccaaagt aaacattgcc ccaaagtgct cccaaagctt gctggcacat    420

aaacatgaat gaatgaacaa tgtagaattc actcaagaaa tttcaaggag agagaggagg    480

agatttacat cacacagcaa acaacctaat aaatctgtta aacgccatgc atgtgaatag    540

gcgttttcct ctttttgacc ctttctttcc acatagaact cagtgctcct tcctcgtcct    600

ccgttacagt atttatcgcc ttccttcttc cacgccgggg agcagtcgag gcttgtgttc    660

ttcagcggac ttgccaaatc atcccctcca gcatgctgct ctc                      703


<210>  3071
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  3071

Met Gln Trp Asn Arg Met Lys Gly Cys Lys Ser Gln Ser Ser Gln Leu 
1               5                   10                  15


Gln Val Gly Gln Ser Lys His Cys Pro Lys Val Leu Pro Lys Leu Ala 
            20                  25                  30


Gly Thr 



<210>  3072
<211>  748
<212>  DNA
<213>  Homo sapiens

<400>  3072
gaaccatgag aaagctttaa atggggatgt aaaatatgat ctgtggaagg gagagagcag     60

catgctggag gggatgattt ggcaagtccg ctgaagaaca caagcctcga ctgctccccg    120

gcgtggaaga aggaaggcga taaatactgt aacggaggac gaggaaggag cactgagttc    180

tatgtggaaa gaaagggtca aaaagaggaa aacgcctatt cacatgcatg gcgtttaaca    240

gatttattag gttgtttgct gtgtgatgta aatctcctcc tctctctcct tgaaatttct    300

tgagtgaatt ctacattgtt cattcattca tgtttatgtg ccagcaagct ttgggagcac    360

tgtaaaaata aaaaaggtta gaccactgtt agacatctgg gaaacatcta tgttagagaa    420

ggactatata ttaatttatc tcatttatgg gaggcaaata ctatgattat tgaaggtaca    480

tctctttctt tatggatgga gtacatctta tttttctaaa atttgtattt gaacctattt    540

atttctaatt gtcaaaaatg tgaagtgaga aacttaaaaa ctttttagtt tctcttgtcc    600

caccatttta tgtacttcca ggttgtcaaa taatttggaa ttttagactt agataattct    660

ctaatgtata ttatagatct tctatttcaa taattagctt atattttaat taaattgtat    720

aactgcatta aaatatactt aactatgt                                       748


<210>  3073
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  3073

Ser Val Glu Gly Arg Glu Gln His Ala Gly Gly Asp Asp Leu Ala Ser 
1               5                   10                  15


Pro Leu Lys Asn Thr Ser Leu Asp Cys Ser Pro Ala Trp Lys Lys Glu 
            20                  25                  30


Gly Asp Lys Tyr Cys Asn Gly Gly Arg Gly Arg Ser Thr Glu Phe Tyr 
        35                  40                  45


Val Glu Arg Lys Gly Gln Lys Glu Glu Asn Ala Tyr Ser His Ala Trp 
    50                  55                  60


Arg Leu Thr Asp Leu Leu Gly Cys Leu Leu Cys Asp Val Asn Leu Leu 
65                  70                  75                  80


Leu Ser Leu Leu Glu Ile Ser 
                85


<210>  3074
<211>  1064
<212>  DNA
<213>  Homo sapiens

<400>  3074
ggtcattcag acagaactgt ccactaagaa gaaatggaat ctatggttct gcaggtcaga     60

atggtctgta ccagagatga agtcatcggt ctacagatga attgagtgaa agcaatcacc    120

cagagccagg caaggtgtca gagctccaac atcaaaaggt ggttgactgg tgggttggta    180

agaagaattt accactgacc gtataggact ggaaaaggaa aggtttatta ggtagaaaga    240

acgctgtcga agagtgcagc tgcagcggag cacctcagca agagaggact gagtgcaaca    300

cagtggatcc ttcctcaggg gtatttatgg accttaaagc cggagctgaa gatgatctgt    360

ggaagggaga gagcagcatg ctggagggga tgatttggca agtccgctga agaacacaag    420

cctcgactgc tccccggcgt ggaagaagga aggcgataaa tactgtaacg gaggacgagg    480

aaggagcact gagttctatg tggaaagaaa gggtcaaaaa gaggaaaacg cctattcaca    540

tgcatggcgt ttaacagatt tattaggttg tttgctgtgt gatgtaaatc tcctcctctc    600

tctccttgaa atttcttgag tgaattctac attgttcatt cattcatgtt tatgtgccag    660

caagctttgg gagcactgta aaaataaaaa aggttagacc actgttagac atctgggaaa    720

catctatgtt agagaaggac tatatattaa tttatctcat ttatgggagg caaatactat    780

gattattgaa ggtacatctc tttctttatg gatggagtac atcttatttt tctaaaattt    840

gtatttgaac ctatttattt ctaattgtca aaaatgtgaa gtgagaaact taaaaacttt    900

ttagtttctc ttgtcccacc attttatgta cttccaggtt gtcaaataat ttggaatttt    960

agacttagat aattctctaa tgtatattat agatcttcta tttcaataat tagcttatat   1020

tttaattaaa ttgtataact gcattaaaat atacttaact atgt                    1064


<210>  3075
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  3075

Ser Val Glu Gly Arg Glu Gln His Ala Gly Gly Asp Asp Leu Ala Ser 
1               5                   10                  15


Pro Leu Lys Asn Thr Ser Leu Asp Cys Ser Pro Ala Trp Lys Lys Glu 
            20                  25                  30


Gly Asp Lys Tyr Cys Asn Gly Gly Arg Gly Arg Ser Thr Glu Phe Tyr 
        35                  40                  45


Val Glu Arg Lys Gly Gln Lys Glu Glu Asn Ala Tyr Ser His Ala Trp 
    50                  55                  60


Arg Leu Thr Asp Leu Leu Gly Cys Leu Leu Cys Asp Val Asn Leu Leu 
65                  70                  75                  80


Leu Ser Leu Leu Glu Ile Ser 
                85


<210>  3076
<211>  1621
<212>  DNA
<213>  Homo sapiens

<400>  3076
tatttttttt agaactctaa tatgaaaatc tggttgattt caataattaa gcctagaaag     60

aaatgaatat gtaagcatat atgaaaggat taatattact aggtgttatt ttgtacataa    120

aatgaggcat agacttataa aacattagaa tcaaataaca tttctggaaa tttaggccat    180

attgaaatta taatgtttct tttaaaatgt ttgttctgca aacctaattg agccatagag    240

ttaaaaccct taatcttcca ttttcagttt catagtactt ttttctgctt tatttttatc    300

tgctctaggt attgtattcg tattcaattg gttttgtata cattttactg ggattgacat    360

gcactagtgg attaggccct gcagtaacat tttgtgcaaa ggtaaacact aatcacattt    420

aaaaaaaaaa atcttctgtt aaataatttt ctctaaattt ctcatttccc ttgttcaaaa    480

gaggctatca tagatataat gatacctcct ttaacataac atgccaatcg gaaattaatt    540

tcagaaatga aatgactgat atttaaattt attttatcct tgctgtaccc tatgagttga    600

tttttaagct gttcataatg taggaaagtt gaggatcttt aatttcaaca tttttttttc    660

attaaatcaa aataagaatc tttgcttgac tgcattgtca aacaacttat tgctcaagaa    720

gttgattaac atctgtagtt ttattttatt tgtaatacct cggagtttgt tttacatttt    780

tctaacaggc ttttttattt tttgcagaat ccagttcgga cctatggtta tgcgttcctt    840

ttttccctca ctggatattt tggaatctcc tttgttctgg ctttgattaa aatttttggt    900

gcacttattg ctgtaacagt gacaacagga agaaaagcaa tgaccattgt actttcgttt    960

atattctttg ctaaaccatt cacgtttcag tatgtatggt ctggtttgtt agttgtcctt   1020

ggtatatttc ttaatgttta cagcaaaaat atggataaaa taagactacc atcactgtat   1080

gatttgataa acaaatcagt ggaagcaaga aagtcaagga cgctggcaca gactgtatag   1140

acagtgattg tcctatttaa aatagaattt taagggaaca atcatcaatt aattaacttt   1200

ccaaagggac tgataaaaac caaaggatct ggaggcattg ctatcccatt tgtggacaga   1260

tttcatatga agttgttttg cggtgtcagc cttttcttca gagcatttgt ttgactgact   1320

tccaaagcaa tcaagagagc cacgtctagc agactttaca ataaaatgtc aatatgaagg   1380

actgtaattc ctagcagttt attgagaatt tcactggaaa tggaccatgt gttgcaagac   1440

taattggcta taattatatc ctatcaaaga aatcgatacg taatagcaga ttgttttata   1500

ttcattccat tttgatggtg ttatttaaat tgattctctg ttataagagt aaactgatga   1560

gttgaagtct ggagagaata acattcatta taaataaaat tattctgtga tcttttttca   1620

a                                                                   1621


<210>  3077
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  3077

Met Thr Ile Val Leu Ser Phe Ile Phe Phe Ala Lys Pro Phe Thr Phe 
1               5                   10                  15


Gln Tyr Val Trp Ser Gly Leu Leu Val Val Leu Gly Ile Phe Leu Asn 
            20                  25                  30


Val Tyr Ser Lys Asn Met Asp Lys Ile Arg Leu Pro Ser Leu Tyr Asp 
        35                  40                  45


Leu Ile Asn Lys Ser Val Glu Ala Arg Lys Ser Arg Thr Leu Ala Gln 
    50                  55                  60


Thr Val 
65


<210>  3078
<211>  2124
<212>  DNA
<213>  Homo sapiens

<400>  3078
gaagtggcct gcgggcgccg gagttgagag tgctttccgg ggaggcgacc gccgcggtgg     60

aaagtgcagg agtgggcgag gaggaggagg aagaggaggt gatggcgacg gaccagggga    120

gggggagatg ctccgtctag ctcagacgcc acgcaggctg ccgtcaccct tccgggtgac    180

ataccggcct tggggtacgc gtgccttcgg ggcctttcct gtgtttggga cccagatctc    240

ctctcctcca gaaaaccttg acactgccca tcttcctcat ccagaaggag cgttcgagga    300

atggatgagg tcgggatgga agaaacgggt gattcccttt tttgaaagag cggaaaccgg    360

ccgggcggtt tccagggagg agcatctgtt cctcctcgcc cgtttttcgc cctcgggctg    420

gcgagaactc cctcaggtcc caatccgtgg actcgcaggg gtgaggtgac ctcaaggggt    480

cttttacgct gttctcgggg tctctggaga actgtcagtc acctggatac ctctagactg    540

tatttacagt taactgtttc ctcgttccgt gtttattaaa taggggcact ccaaggactt    600

gacacagcaa gcaaaagaca tacagaacat aacagtccag gaaaccaaca aaaataactc    660

tgaaagcatt gaatgcagca aaataacaat ggatctcaag ttcaacaatt ccaggaaata    720

tatttctatc actgtgccat ccaaaaccca aacaatgtca ccacacatca agtcagttga    780

cgacgttgtg gtacttggca tgaatctcag caagtttaac aaacttactc agtttttcat    840

atgtgttgct ggagtttttg tattttacct aatttatggg tatttacagg aattaatatt    900

ttcagtggag ggttttaagt cctgtggctg gtaccttacc ttagtgcagt ttgcctttta    960

ctccatattt ggcctaatag aacttcagct tattcaggac aaaaggagga ggaaagcgtt   1020

ataatgttgc agatgtgtct gctgccatat gtatgagcct tggcctgata tggtttaccc   1080

tcgctgacag cacaactgca ccaaatttca acctgacggg tgtggtgctt atttccctgg   1140

cactatgtgc agatgccgtc attggaaatg ttcaagagaa agctatgaaa cttcataatg   1200

cttctaattc tgaaatggta ttgtattcgt attcaattgg ttttgtatac attttactgg   1260

gattgacatg cactagtgga ttaggccctg cagtaacatt ttgtgcaaag aatccagttc   1320

ggacctatgg ttatgcgttc cttttttccc tcactggata ttttggaatc tcctttgttc   1380

tggctttgat taaaattttt ggtgcactta ttgctgtaac agtgacaaca ggaagaaaag   1440

caatgaccat tgtactttcg tttatattct ttgctaaacc attcacgttt cagtatgtat   1500

ggtctggttt gttagttgtc cttggtatat ttcttaatgt ttacagcaaa aatatggata   1560

aaataagact accatcactg tatgatttga taaacaaatc agtggaagca agaaagtcaa   1620

ggacgctggc acagactgta tagacagtga ttgtcctatt taaaatagaa ttttaaggga   1680

acaatcatca attaattaac tttccaaagg gactgataaa aaccaaagga tctggaggca   1740

ttgctatccc atttgtggac agatttcata tgaagttgtt ttgcggtgtc agccttttct   1800

tcagagcatt tgtttgactg acttccaaag caatcaagag agccacgtct agcagacttt   1860

acaataaaat gtcaatatga aggactgtaa ttcctagcag tttattgaga atttcactgg   1920

aaatggacca tgtgttgcaa gactaattgg ctataattat atcctatcaa agaaatcgat   1980

acgtaatagc agattgtttt atattcattc cattttgatg gtgttattta aattgattct   2040

ctgttataag agtaaactga tgagttgaag tctggagaga ataacattca ttataaataa   2100

aattattctg tgatcttttt tcaa                                          2124


<210>  3079
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  3079

Met Ser Leu Gly Leu Ile Trp Phe Thr Leu Ala Asp Ser Thr Thr Ala 
1               5                   10                  15


Pro Asn Phe Asn Leu Thr Gly Val Val Leu Ile Ser Leu Ala Leu Cys 
            20                  25                  30


Ala Asp Ala Val Ile Gly Asn Val Gln Glu Lys Ala Met Lys Leu His 
        35                  40                  45


Asn Ala Ser Asn Ser Glu Met Val Leu Tyr Ser Tyr Ser Ile Gly Phe 
    50                  55                  60


Val Tyr Ile Leu Leu Gly Leu Thr Cys Thr Ser Gly Leu Gly Pro Ala 
65                  70                  75                  80


Val Thr Phe Cys Ala Lys Asn Pro Val Arg Thr Tyr Gly Tyr Ala Phe 
                85                  90                  95


Leu Phe Ser Leu Thr Gly Tyr Phe Gly Ile Ser Phe Val Leu Ala Leu 
            100                 105                 110


Ile Lys Ile Phe Gly Ala Leu Ile Ala Val Thr Val Thr Thr Gly Arg 
        115                 120                 125


Lys Ala Met Thr Ile Val Leu Ser Phe Ile Phe Phe Ala Lys Pro Phe 
    130                 135                 140


Thr Phe Gln Tyr Val Trp Ser Gly Leu Leu Val Val Leu Gly Ile Phe 
145                 150                 155                 160


Leu Asn Val Tyr Ser Lys Asn Met Asp Lys Ile Arg Leu Pro Ser Leu 
                165                 170                 175


Tyr Asp Leu Ile Asn Lys Ser Val Glu Ala Arg Lys Ser Arg Thr Leu 
            180                 185                 190


Ala Gln Thr Val 
        195


<210>  3080
<211>  6156
<212>  DNA
<213>  Homo sapiens

<400>  3080
aggcggaagt ggcctgcggg cgccggagtt gagagtgctt tccggggagg cgaccgccgc     60

ggtggaaagt gcaggagtgg gcgaggagga ggaggaagag gaggtgatgg cgacggacca    120

ggggaggggg agatgctccg tctagctcag acgccacgca ggctgccgtc acccttccgg    180

gtgacatacc ggccttgggg ccatgattga ttccggagcg cagttaatca aggcataatg    240

gcatggtaag attcttttat ttgtaacgtt gagtgtggca aagtatagtt aaaatcacgt    300

tttttcaggt taatgacacc gtaatgactt ttttttcata ttctaccttt ttttggtgtg    360

ggacttttgt ccttcaggtc ggaaaactca aaaataaact gaaataattg tgacttcaat    420

aggtcattgt aactcaacat tatcactaat tttaattttt aaatatacat tgtatgccgg    480

aaatgctacc tttttattcc attttagcag ttgaagttga atatctgtgt tgaatttagg    540

aagaggcctc aggcaattat acacacctgt gatttttaaa atatatatat atatatttta    600

gtttcactga ttactgtgag cttcaaaagc aaagcacaat gttgatcatt tagtctgaaa    660

actaatttta attccatgct tcatttttgc tccttgcatc acaaggagtt tggcccattt    720

ttttttttag atgatggtta gtatcagtca ttaatgtttg aagtggaagg gatatggcag    780

acattcccca atgatcacag ttattaggta tcagaggtct ttatcagtca cactttctca    840

ccagtgatgt tcttattaat aaaacagcat tctaaatgca aggctttggt gggcaagttt    900

tatgagactg atgcctcagg cagaggaaac aaatttattt tcatgttcat ttcaaatgtt    960

ttgtggggag tttcagtagc aatgtcggta ttttggcata catgtagaaa agacagtgct   1020

agagagattt cattctgcac atatggccta gatctgcagc acataaagtt gccaagaagt   1080

gtattagaag tggtaaagtg ttggaaagga gctgaataac gttgattaaa taaatggtgc   1140

ttgctaaact gtggtagagt ccttcattta atcttacatt tttgttatgt gccagaacat   1200

cataggaaga tatctcttgc cttaaggatt tcataggctt ttaggagaaa caagtataaa   1260

aacgaaaaag ctataccatt atcatttagg aatttgaaaa atatgtataa tatgattgag   1320

tccaggacat caactcgttt ttaacttcga ggccttattc atggatgcag catgatcaga   1380

cttcacgttg agccatgtga cagatgggtc agaaagggaa gaattgatta taaacagtct   1440

cgtaatctag gcaagagaaa atggctgcct gatggagtag ggtccgaaac agatattaga   1500

tatagttata gaggtagagt taacaggaat cttggcaaaa tatagaatgt gaggaaaagg   1560

aaagattctt aagatgactc ccagattttt agcttgtgtt tcatactagg tactgttaag   1620

tgagattggg aatataggaa caaacagtag atttgttttg aggggaaaat aatcagcttt   1680

ggccatttta aatatgaagt gccagcagag cttatgagta gaggtatcaa agaagcattt   1740

agacgtagag ctctggatct caggagagaa ggcagcgttg gaaattcagg tctgtatttc   1800

cagctgcaca tcaaaggggt gagtcagctt gagcacacca tatcacccta gcaatatttc   1860

taaaaagttg aaggatgaca gctaacacac ttatggactg tcatatgcca ggcaatttta   1920

catttatttc atatagtcct aaccaaaatc ctgtgatagg cacattttta actcctccca   1980

cttttgaagg tgcagaacct aaagctcaga aaagttaaac gatttgccca aggctcctca   2040

gctaataagt agtaaagcca gatcttgaac tcatatctgt caaaattcca aagcatgggg   2100

aaagcattat gctatactgc tttcttatac tattacctat aattgtattg agtcattaca   2160

atatgcttgg cagtttacta aattacaaac atctcagaag aaggtgactt tgggaaagcg   2220

tgaccttctg gagaaatgtt ttgatgccaa taaaagcagg aaagaaagat attttctaga   2280

agttttattt attctgtatg tatgtgtaaa tatgtaagca ttatttgtaa attttcccca   2340

ctctttttct ataagatttt cagttttgct cataaagttt gccagtacca ccatccattt   2400

caaaaatcgt atccaagcag aaggtgagtg attgcaagct gaagtttgag ggtatcaaga   2460

ggaaggatca gtttatttgg ttcatctgaa tatcaggtca gagtatatgc caggtaccaa   2520

ggacacagag acaaataaga tttgaatctt gcctttcaag ttctcttttc taataactgg   2580

ggggattagt gatggtgtca caaaggaggg gatattaaag ctgaacttcc aaacctgacc   2640

ttgagaaaga agacctcagg ctgaaaggac atcatgaaca gaaggcagcg gtgttttaaa   2700

gtccctggtg tatttcagga atgaaacatg ggtggtttag ggctttattg agagtggagg   2760

gagagcaaac ttagaaacct atgtaaggcc gggtttattt gaatggtgca ctatatccat   2820

gctcacacat agaaaagagt aaattgttaa ggttttcgtc tcttctacat tcaagcacag   2880

gtttgaccaa atatttagga gagataattt aaagcatggt tttaaaagaa agtcacatct   2940

caaagatacc ctgcaagatt acataaaaag tcttacaaat gacagtgatt gaaacataat   3000

gtgggaagca agaacaaagg aaagtgaaga ataaacaaga ggaacacagt aaacttcatg   3060

aaacaacttt tctatttaga aataaggcag gtgccctata aaatgttgtg gtggctgcat   3120

atttttagtt acaagtggta ttcagatcct tgacccctcc tttaattcct aaggatgacc   3180

tggttaacct ctgtaaatta gcaaactaga agtgatcatg aagaggcgac tctaattttg   3240

gccattttaa gccatcttgt aacagtttaa aaaaacatta ccaaaggaaa actcactgtc   3300

aaaattattc ttatttctct tcgtgccgca gagtttaaat ttttgttccc actggaatta   3360

aaaacagatg agtcgtttct aagaaaataa ctttttcttt tacataggtt tattctatac   3420

tttgtcataa ttcttcagtc tttcctcagt ctttacatgg agttcatttt ttcagtttat   3480

ataaatccaa agagaaattg atggcttcat aatttttttt agactgacaa aaaatgacat   3540

gttttctcca gccttttaca tcccagaaga atgtaaatta aaatgatttg ttccagagga   3600

agaaaacatt ttttaaccta agagatgcta ctgctgaagc atattgtgct ttctgtagtc   3660

tctgataaat ctagcttttt aaggacctta ggtttggggt ttctttgttt tgtttttttc   3720

atttattttc tagagacagg gtctggctct gtcgcccagg ctggagtgca ggggtgcaat   3780

catagattac tgcagcctca aactcctgga ctcaagtgat catcctgcct cagcctccca   3840

agtagctagg actacaggca tgcaccacca tgtccagcta atttttttat tttattttat   3900

tttattttat ttggtagaga gagggtcttg ctatgttgcc caggctggtc ttgaactcct   3960

ggtctcaagc aacctctctg cttcagcctc ccaaaatgtt gggattacag gcatgagcca   4020

ccacacctgg ccttcatttt tttagtttat tttttaaatg tcattagcaa atatatctta   4080

gaattgtctt agtatttaaa ggagaattac ttatttttta ctcctctaca agtgaagatt   4140

gactttaatg ttgagaatgt tatgcatcaa ctatatatag acacaaagac atgtttagtt   4200

ctttgatgaa ataactagct tttgttgctg tggaaataag tatggtttat attcagttta   4260

atgatgtact aatctttatc agctgtagac aaattgttta aagattgtag gcatattgtt   4320

tttggtgatt tggaacctag aatacaggaa ttaatatact aatatccaga gagaagcaga   4380

catttgtata actttaaagt atgatttgga atattatttg gaggattaaa ctttatcatg   4440

taaatgtttt aattgcttat ttccttctct aggacttgac acagcaagca aaagacatac   4500

agaacataac agtccaggaa accaacaaaa ataactctga aagcattgaa tgcagcaaaa   4560

taacaatgga tctcaagttc aacaattcca ggaaatatat ttctatcact gtgccatcca   4620

aaacccaaac aatgtcacca cacatcaagt cagttgacga cgttgtggta cttggcatga   4680

atctcagcaa gtttaacaaa cttactcagt ttttcatatg tgttgctgga gtttttgtat   4740

tttacctaat ttatgggtat ttacaggaat taatattttc agtggagggt tttaagtcct   4800

gtggctggta ccttacctta gtgcagtttg ccttttactc catatttggc ctaatagaac   4860

ttcagcttat tcaggacaaa aggaggagaa taccaggaaa aacctacatg ataatagctt   4920

ttctaactgt gggtactatg gggttatcaa acacttcctt gggctacctg aattacccta   4980

cccaagtcat cttcaagtgc tgcaaattga ttcctgttat gctaggagga gtttttattc   5040

aaggaaagcg ttataatgtt gcagatgtgt ctgctgccat atgtatgagc cttggcctga   5100

tatggtttac cctcgctgac agcacaactg caccaaattt caacctgacg ggtgtggtgc   5160

ttatttccct ggcactatgt gcagatgccg tcattggaaa tgttcaagag aaagctatga   5220

aacttcataa tgcttctaat tctgaaatgg tattgtattc gtattcaatt ggttttgtat   5280

acattttact gggattgaca tgcactagtg gattaggccc tgcagtaaca ttttgtgcaa   5340

agaatccagt tcggacctat ggttatgcgt tccttttttc cctcactgga tattttggaa   5400

tctcctttgt tctggctttg attaaaattt ttggtgcact tattgctgta acagtgacaa   5460

caggaagaaa agcaatgacc attgtacttt cgtttatatt ctttgctaaa ccattcacgt   5520

ttcagtatgt atggtctggt ttgttagttg tccttggtat atttcttaat gtttacagca   5580

aaaatatgga taaaataaga ctaccatcac tgtatgattt gataaacaaa tcagtggaag   5640

caagaaagtc aaggacgctg gcacagactg tatagacagt gattgtccta tttaaaatag   5700

aattttaagg gaacaatcat caattaatta actttccaaa gggactgata aaaaccaaag   5760

gatctggagg cattgctatc ccatttgtgg acagatttca tatgaagttg ttttgcggtg   5820

tcagcctttt cttcagagca tttgtttgac tgacttccaa agcaatcaag agagccacgt   5880

ctagcagact ttacaataaa atgtcaatat gaaggactgt aattcctagc agtttattga   5940

gaatttcact ggaaatggac catgtgttgc aagactaatt ggctataatt atatcctatc   6000

aaagaaatcg atacgtaata gcagattgtt ttatattcat tccattttga tggtgttatt   6060

taaattgatt ctctgttata agagtaaact gatgagttga agtctggaga gaataacatt   6120

cattataaat aaaattattc tgtgatcttt tttcaa                             6156


<210>  3081
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  3081

Met Asp Leu Lys Phe Asn Asn Ser Arg Lys Tyr Ile Ser Ile Thr Val 
1               5                   10                  15


Pro Ser Lys Thr Gln Thr Met Ser Pro His Ile Lys Ser Val Asp Asp 
            20                  25                  30


Val Val Val Leu Gly Met Asn Leu Ser Lys Phe Asn Lys Leu Thr Gln 
        35                  40                  45


Phe Phe Ile Cys Val Ala Gly Val Phe Val Phe Tyr Leu Ile Tyr Gly 
    50                  55                  60


Tyr Leu Gln Glu Leu Ile Phe Ser Val Glu Gly Phe Lys Ser Cys Gly 
65                  70                  75                  80


Trp Tyr Leu Thr Leu Val Gln Phe Ala Phe Tyr Ser Ile Phe Gly Leu 
                85                  90                  95


Ile Glu Leu Gln Leu Ile Gln Asp Lys Arg Arg Arg Ile Pro Gly Lys 
            100                 105                 110


Thr Tyr Met Ile Ile Ala Phe Leu Thr Val Gly Thr Met Gly Leu Ser 
        115                 120                 125


Asn Thr Ser Leu Gly Tyr Leu Asn Tyr Pro Thr Gln Val Ile Phe Lys 
    130                 135                 140


Cys Cys Lys Leu Ile Pro Val Met Leu Gly Gly Val Phe Ile Gln Gly 
145                 150                 155                 160


Lys Arg Tyr Asn Val Ala Asp Val Ser Ala Ala Ile Cys Met Ser Leu 
                165                 170                 175


Gly Leu Ile Trp Phe Thr Leu Ala Asp Ser Thr Thr Ala Pro Asn Phe 
            180                 185                 190


Asn Leu Thr Gly Val Val Leu Ile Ser Leu Ala Leu Cys Ala Asp Ala 
        195                 200                 205


Val Ile Gly Asn Val Gln Glu Lys Ala Met Lys Leu His Asn Ala Ser 
    210                 215                 220


Asn Ser Glu Met Val Leu Tyr Ser Tyr Ser Ile Gly Phe Val Tyr Ile 
225                 230                 235                 240


Leu Leu Gly Leu Thr Cys Thr Ser Gly Leu Gly Pro Ala Val Thr Phe 
                245                 250                 255


Cys Ala Lys Asn Pro Val Arg Thr Tyr Gly Tyr Ala Phe Leu Phe Ser 
            260                 265                 270


Leu Thr Gly Tyr Phe Gly Ile Ser Phe Val Leu Ala Leu Ile Lys Ile 
        275                 280                 285


Phe Gly Ala Leu Ile Ala Val Thr Val Thr Thr Gly Arg Lys Ala Met 
    290                 295                 300


Thr Ile Val Leu Ser Phe Ile Phe Phe Ala Lys Pro Phe Thr Phe Gln 
305                 310                 315                 320


Tyr Val Trp Ser Gly Leu Leu Val Val Leu Gly Ile Phe Leu Asn Val 
                325                 330                 335


Tyr Ser Lys Asn Met Asp Lys Ile Arg Leu Pro Ser Leu Tyr Asp Leu 
            340                 345                 350


Ile Asn Lys Ser Val Glu Ala Arg Lys Ser Arg Thr Leu Ala Gln Thr 
        355                 360                 365


Val 



<210>  3082
<211>  2205
<212>  DNA
<213>  Homo sapiens

<400>  3082
agggacacat aggcggaagt ggcctgcggg cgccggagtt gagagtgctt tccggggagg     60

cgaccgccgc ggtggaaagt gcaggagtgg gcgaggagga ggaggaagag gaggtgatgg    120

cgacggacca ggggaggggg agatgctccg tctagctcag acgccacgca ggctgccgtc    180

acccttccgg gtgacatacc ggccttgggg tacgcgtgcc ttcggggcct ttcctgtgtt    240

tgggacccag atctcctctc ctccagaaaa ccttgacact gcccatcttc ctcatccaga    300

aggagcgttc gaggaatgga tgaggtcggg atggaagaaa cgggtgattc ccttttttga    360

aagagcggaa accggccggg cggtttccag ggaggagcat ctgttcctcc tcgcccgttt    420

ttcgccctcg ggctggcgag aactccctca ggtcccaatc cgtggactcg caggggccat    480

gattgattcc ggagcgcagt taatcaaggc ataatggcat ggacttgaca cagcaagcaa    540

aagacataca gaacataaca gtccaggaaa ccaacaaaaa taactctgaa agcattgaat    600

gcagcaaaat aacaatggat ctcaagttca acaattccag gaaatatatt tctatcactg    660

tgccatccaa aacccaaaca atgtcaccac acatcaagtc agttgacgac gttgtggtac    720

ttggcatgaa tctcagcaag tttaacaaac ttactcagtt tttcatatgt gttgctggag    780

tttttgtatt ttacctaatt tatgggtatt tacaggaatt aatattttca gtggagggtt    840

ttaagtcctg tggctggtac cttaccttag tgcagtttgc cttttactcc atatttggcc    900

taatagaact tcagcttatt caggacaaaa ggaggagaat accaggaaaa acctacatga    960

taatagcttt tctaactgtg ggtactatgg ggttatcaaa cacttccttg ggctacctga   1020

attaccctac ccaagtcatc ttcaagtgct gcaaattgat tcctgttatg ctaggaggag   1080

tttttattca aggaaagcgt tataatgttg cagatgtgtc tgctgccata tgtatgagcc   1140

ttggcctgat atggtttacc ctcgctgaca gcacaactgc accaaatttc aacctgacgg   1200

gtgtggtgct tatttccctg gcactatgtg cagatgccgt cattggaaat gttcaagaga   1260

aagctatgaa acttcataat gcttctaatt ctgaaatggt attgtattcg tattcaattg   1320

gttttgtata cattttactg ggattgacat gcactagtgg attaggccct gcagtaacat   1380

tttgtgcaaa gaatccagtt cggacctatg gttatgcgtt ccttttttcc ctcactggat   1440

attttggaat ctcctttgtt ctggctttga ttaaaatttt tggtgcactt attgctgtaa   1500

cagtgacaac aggaagaaaa gcaatgacca ttgtactttc gtttatattc tttgctaaac   1560

cattcacgtt tcagtatgta tggtctggtt tgttagttgt ccttggtata tttcttaatg   1620

tttacagcaa aaatatggat aaaataagac taccatcact gtatgatttg ataaacaaat   1680

cagtggaagc aagaaagtca aggacgctgg cacagactgt atagacagtg attgtcctat   1740

ttaaaataga attttaaggg aacaatcatc aattaattaa ctttccaaag ggactgataa   1800

aaaccaaagg atctggaggc attgctatcc catttgtgga cagatttcat atgaagttgt   1860

tttgcggtgt cagccttttc ttcagagcat ttgtttgact gacttccaaa gcaatcaaga   1920

gagccacgtc tagcagactt tacaataaaa tgtcaatatg aaggactgta attcctagca   1980

gtttattgag aatttcactg gaaatggacc atgtgttgca agactaattg gctataatta   2040

tatcctatca aagaaatcga tacgtaatag cagattgttt tatattcatt ccattttgat   2100

ggtgttattt aaattgattc tctgttataa gagtaaactg atgagttgaa gtctggagag   2160

aataacattc attataaata aaattattct gtgatctttt ttcaa                   2205


<210>  3083
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  3083

Met Asp Leu Thr Gln Gln Ala Lys Asp Ile Gln Asn Ile Thr Val Gln 
1               5                   10                  15


Glu Thr Asn Lys Asn Asn Ser Glu Ser Ile Glu Cys Ser Lys Ile Thr 
            20                  25                  30


Met Asp Leu Lys Phe Asn Asn Ser Arg Lys Tyr Ile Ser Ile Thr Val 
        35                  40                  45


Pro Ser Lys Thr Gln Thr Met Ser Pro His Ile Lys Ser Val Asp Asp 
    50                  55                  60


Val Val Val Leu Gly Met Asn Leu Ser Lys Phe Asn Lys Leu Thr Gln 
65                  70                  75                  80


Phe Phe Ile Cys Val Ala Gly Val Phe Val Phe Tyr Leu Ile Tyr Gly 
                85                  90                  95


Tyr Leu Gln Glu Leu Ile Phe Ser Val Glu Gly Phe Lys Ser Cys Gly 
            100                 105                 110


Trp Tyr Leu Thr Leu Val Gln Phe Ala Phe Tyr Ser Ile Phe Gly Leu 
        115                 120                 125


Ile Glu Leu Gln Leu Ile Gln Asp Lys Arg Arg Arg Ile Pro Gly Lys 
    130                 135                 140


Thr Tyr Met Ile Ile Ala Phe Leu Thr Val Gly Thr Met Gly Leu Ser 
145                 150                 155                 160


Asn Thr Ser Leu Gly Tyr Leu Asn Tyr Pro Thr Gln Val Ile Phe Lys 
                165                 170                 175


Cys Cys Lys Leu Ile Pro Val Met Leu Gly Gly Val Phe Ile Gln Gly 
            180                 185                 190


Lys Arg Tyr Asn Val Ala Asp Val Ser Ala Ala Ile Cys Met Ser Leu 
        195                 200                 205


Gly Leu Ile Trp Phe Thr Leu Ala Asp Ser Thr Thr Ala Pro Asn Phe 
    210                 215                 220


Asn Leu Thr Gly Val Val Leu Ile Ser Leu Ala Leu Cys Ala Asp Ala 
225                 230                 235                 240


Val Ile Gly Asn Val Gln Glu Lys Ala Met Lys Leu His Asn Ala Ser 
                245                 250                 255


Asn Ser Glu Met Val Leu Tyr Ser Tyr Ser Ile Gly Phe Val Tyr Ile 
            260                 265                 270


Leu Leu Gly Leu Thr Cys Thr Ser Gly Leu Gly Pro Ala Val Thr Phe 
        275                 280                 285


Cys Ala Lys Asn Pro Val Arg Thr Tyr Gly Tyr Ala Phe Leu Phe Ser 
    290                 295                 300


Leu Thr Gly Tyr Phe Gly Ile Ser Phe Val Leu Ala Leu Ile Lys Ile 
305                 310                 315                 320


Phe Gly Ala Leu Ile Ala Val Thr Val Thr Thr Gly Arg Lys Ala Met 
                325                 330                 335


Thr Ile Val Leu Ser Phe Ile Phe Phe Ala Lys Pro Phe Thr Phe Gln 
            340                 345                 350


Tyr Val Trp Ser Gly Leu Leu Val Val Leu Gly Ile Phe Leu Asn Val 
        355                 360                 365


Tyr Ser Lys Asn Met Asp Lys Ile Arg Leu Pro Ser Leu Tyr Asp Leu 
    370                 375                 380


Ile Asn Lys Ser Val Glu Ala Arg Lys Ser Arg Thr Leu Ala Gln Thr 
385                 390                 395                 400


Val 



<210>  3084
<211>  7357
<212>  DNA
<213>  Homo sapiens

<400>  3084
gcacgcgcgc agggacacat aggcggaagt ggcctgcggg cgccggagtt gagagtgctt     60

tccggggagg cgaccgccgc ggtggaaagt gcaggagtgg gcgaggagga ggaggaagag    120

gaggtgatgg cgacggacca ggggaggggg agatgctccg tctagctcag acgccacgca    180

ggctgccgtc acccttccgg gtgacatacc ggccttgggg acttgacaca gcaagcaaaa    240

gacatacaga acataacagt ccaggaaacc aacaaaaata actctgaaag cattgaatgc    300

agcaaaataa caatggatct caagttcaac aattccagga aatatatttc tatcactgtg    360

ccatccaaaa cccaaacaat gtcaccacac atcaagtcag ttgacgacgt tgtggtactt    420

ggcatgaatc tcagcaagtt taacaaactt actcagtttt tcatatgtgt tgctggagtt    480

tttgtatttt acctaattta tgggtattta caggaattaa tattttcagt ggagggtttt    540

aagtcctgtg gctggtacct taccttagtg cagtttgcct tttactccat atttggccta    600

atagaacttc agcttattca ggacaaaagg aggaggtatg tggtttgttt ttattttttg    660

atatttctat attagttgaa tttttttggc atactgaata tgcatgaaat ttatacttct    720

attaacaaaa catgtgatag gcacgaactc ttagtgtaac taacttaata ctaaatacat    780

tttattcatt tatacactga aaaaaataaa gtcttaaatg cagtattaca aaataaaaaa    840

atattagctt taggctcaac ttagtgttat atgttcttac aacatgataa aaaacacaat    900

gtacatactt gatttgtata aattctgctg aaataggtgc agttactgat ttgtagtaca    960

actaacatca cagtggtgaa atgaaatatc agtacaggtt gagcatccta atccaaaaat   1020

cctaaatcca gaaatgctcc aaaattagaa aagttttgag tgccaatgtg acacaagtgg   1080

aaacttccaa acataagtac ttaacacaaa ttttgttttg tgcacaaaat gatataaaat   1140

gtgcaccatg accagctctg ggacagctgg gatgcagggc accaagttct taagctgcac   1200

acagcatagt gaccttgggt gcagcccaca aaacctttct ttcctcctag gcttcctggc   1260

ctgtgatggg agtggctgcc atgaagaccc atgacatgct ctagagacat tttccccatt   1320

gtcttgggga ttaacattca gatccttgtt aggcaaattt ctgcacccag cttgaatttc   1380

tcctcaaaaa atgggttttt cttttctact gcatcgtcag gttgcaaatt ttctgaaccg   1440

ttttcctctg tttccgtttt aaaatggaat gctttcaaca gcacccaatt accttttgaa   1500

ggctttgctg cttagaaatt tcttccacca gatacactaa atcatctcaa agttccatag   1560

atctctaggg caggggcaaa atgccaccag tctctttgct aaaacataac aagagtcacc   1620

tttgctctag ttcccaacaa gttcctcatg tccatctgag accacctcag tctgaacctt   1680

attgttcata tcactatcag cttttttgcc aaagccattc aacaagtctc taggtggttc   1740

caaactgtcc tacattttcc tgtcttcttc tgagccctcc aaactcttcc agcctctgcc   1800

tgatacccag ttccaaagtt gcttccacat ttttgggtct catttcagca acatctcact   1860

cctggtacca atttactgtt attagtccgt tttcatgctg ctgataaaga catacccgag   1920

actgggaaga aaaagaagtt taattgaact tacagttcca catggcttgg gaggcctcag   1980

aatcatggca ggagtcaaaa gtcacttctt acatggtggt ggcaagagaa aatgaggaag   2040

atgcaaaagc ggaaacccct gataaaacca tcagatcttg tgagacttat tcactaccat   2100

gagaacaata tgggggaaac cacccccatg attcaaatta cctcccactg ggtccctccc   2160

acaacagatg aaaattatgg gagtacaatt ccagatgaga tttgagtggt gacacagcgc   2220

caaaccatat caaaaatgtt ctataaaatt accttcaggt tatgtgtata atgtatatat   2280

gaaacataaa taaatctcat attaagacct gtgtcccatt ccccaagata ccttactatg   2340

cagatgcaaa tattccaaaa cctgaaaaaa atcgaaattt gaaacactct ggtcgccagc   2400

attttggatg agggatacca agtctgtatc tattgttatt ctgctttttt agaatgtgaa   2460

gttatatttt gtgggatatg ccccagctaa cattgccata tgatgtccga tagctgaggt   2520

tgcgttctta agcattagag aaacaaatct cattcctttt catcaagacc aaatgtgctt   2580

gtttgacaat atcatttcag gtagcaacca tctagatttg agaaatatct tgatatatct   2640

ttaatggcat ctagaacaat atgcaataaa acttagtctc tgattataaa cagaaagtgg   2700

ttaggaattt gaatataaaa tgttcttggt taatgtaaga agcgtgctcc ttctgtcgta   2760

ccctaatgtg tgtatatatc gtgtatctat tgggcagttt aaatgtaata acgactgtaa   2820

tactgacata ccttgataca aatgtttaat cctttagtga agatttcaaa aattgtgcag   2880

cttttttttt aatcataaaa tggtgttgaa gtttgtatca aggtaactac agttttacat   2940

atttaaatct atattacagg tttcttcatg ggtctaattt tgcctctcaa cctgtcttta   3000

ttgccaataa attattgtag caattattgt aaaaatattt gaaccttaga atatcatctt   3060

cattattttt atgttctatc atgattctcc atgatagaat catggaggca agctgatgaa   3120

atccaacttc ctcattttac caatgagaaa acaaagacct agaggagtac tgggaatagc   3180

cataggtgat agaataggta attaaatata tctgtcaaga ctaatatata aggaagcttg   3240

atgatgattt actacttatt acaaactact gggccttcta aggtaagatt gcttctaagg   3300

taaaagacac taatactatc tttgtaggtg aaaaatgata caatgatgat gcatgttctg   3360

ttacatttca gaaagaaaca cctccctatc agctaccccg atgagagggg agggggcctc   3420

aagccatgtt tatcccaact tttaaatcac gtgaccataa catattttaa aataaaataa   3480

tttgtacttg atttaaatat aagtgaaata atttgggaga ataatttatg tatttataat   3540

aaatgtaatt atgaattgaa acctttctga atttatttct gcaaatacac ccatatctga   3600

atttatttaa tggtactgct actcgttaga cctttaatta gctaaactct ttgctgttgt   3660

tatttttttc ttcttcccac atttatgtga ataccgacat actggaataa gtacatcaat   3720

actcgttgag aatttggagt tagaaacatg ggtttgggtc ttggcacttg ggtcttatta   3780

catctgtcaa gacctcagag aagtttctat aatactctaa attttatctt gaggctcata   3840

tgtggtaatg cgtgctaaag tacatcataa actgtaatat cctaaatata ctgcttatta   3900

tttttcatca aagaatacct tgtaacatta ttattaatta gtataagttt ctaattaagg   3960

agagtgctca gatttgtctt gaagaggttt ttaaagttaa aattttctcc ccggccaggt   4020

gcagtggctc acgcctgtaa tcctagcact ttgggaggcc gaggcaggtt gatcacctga   4080

ggttaggagt tcgagaccag cctggccaac atggtgaaac cccgtctcta ctaaaaatat   4140

aaaattagct ggacatggtg gcgggcactt gtaatcctag ctactcagga ggtcaggagg   4200

ctgaggcagg agaatggttt gaacctggga ggcggaggtt gcagtgagcc aagatggcgc   4260

cactgcactc cagcctgggc aacaagagcg agactccgtc tcaaaaaaaa aattttctcc   4320

ccatttctaa ggaagcaagc aattgatgta ttaaataaaa tagaaatagt gagtatcctg   4380

gaggcaagct gatcaaatct aatttcttca ttataccaat gagaaaacaa agacctagag   4440

gactgctcag aattttttga gctccttttg gagctacttt tggatttagt tcccctgtca   4500

ggctggtttt ctttctacct gtactgtgct acttttctac tcattccttg taattcttct   4560

gacttgaatt tttattttct gccaatgatt tgccatttat ctttgagaaa atctgaccac   4620

cttgacttgt atcattttac ctggcgaagt ggtgctccac catcactgat gatatcccaa   4680

tgagggtcaa accccatgga tggcatgaac gcatttacac tgatgcatat gggcatgcca   4740

agttgtttcc acgtggattt tcatggttaa ctactatatt agtagttaag tagaaaaaaa   4800

cccctcagaa tcgaatgtaa atgatgcatt ttaattgact ttttccagta aattatttta   4860

ccttatatct aaccatatat aagatgagaa attttgttgc cttgatttca atgtgaacac   4920

aaattctaaa atggaaatta catctaactc tccagcatta tcagtatgaa tagtgcctga   4980

ttgtgtctgt gttcgtcata ccagtagaca agattattag tttagaccat taaatatcta   5040

gtcaaagtga gcatatgctc acagtaatgg ctcaaaattc tgaagatgct aaattaagaa   5100

tctcctttag gaactttaga tagagccaaa gttaaaagac ttgaaatcat gagagagtca   5160

gatacctcat cttaaaagtt gattattata acatagaata tagagagatg atctataaga   5220

tattataata aaaattacat ctagggtttt aaatcacatg aacttttcct agagaaaatc   5280

ttgggttatt ttagcagaat ggatagatgt atttttccta atgctagatg gaaacattag   5340

gaaacagaac aacaattcaa gagttaaaaa ttagttttaa aatgttaagg taccttttac   5400

cattatggag gccaacatta gctgggcatg gtggcgcaca cctgtagtcc cagctactca   5460

ggaggctgag gcaaaagaat ttcttgaacc cgtgaggcag aggttgcact tagctgagat   5520

catgccactg cactccagcc taggcaacag agcgagacct tatctcaagc aaacaacaac   5580

aaaagaagct ctttttctct aacttaagat ggttaagatg gtttttattt gtggctagaa   5640

ctgctgttaa aaaaaaaaaa aaaacctttt gtcaacattt ataccttcag taaaaatcta   5700

aactcttttt tacataattg agtggcctcg tttatgattg actaaataaa ggtaaattgt   5760

tatttttata aactttttta tacaagagca ttacagtttt taaatagtga tattttttac   5820

tgatatttcc agaaatagta accagaaatt agaaaagtaa ttagacattt acacaatgtg   5880

aacacattat cttttagtag tatgaattgg gtcccaaaat gaaggtttta aaaattgtct   5940

tttacagaat accaggaaaa acctacatga taatagcttt tctaactgtg ggtactatgg   6000

ggttatcaaa cacttccttg ggctacctga attaccctac ccaagtcatc ttcaagtgct   6060

gcaaattgat tcctgttatg ctaggaggag tttttattca aggaaagcgt tataatgttg   6120

cagatgtgtc tgctgccata tgtatgagcc ttggcctgat atggtttacc ctcgctgaca   6180

gcacaactgc accaaatttc aacctgacgg gtgtggtgct tatttccctg gcactatgtg   6240

cagatgccgt cattggaaat gttcaagaga aagctatgaa acttcataat gcttctaatt   6300

ctgaaatgaa tattactacc agtagttatt ctggggtgtt tatattccca aataaactaa   6360

aaatcccatt ggtattgtga ttggtatggc attgaattat aaattaattt agggagaatg   6420

gcatcttgat tatttcagtc caagaataag gtattgtatt cgtattcaat tggttttgta   6480

tacattttac tgggattgac atgcactagt ggattaggcc ctgcagtaac attttgtgca   6540

aagaatccag ttcggaccta tggttatgcg ttcctttttt ccctcactgg atattttgga   6600

atctcctttg ttctggcttt gattaaaatt tttggtgcac ttattgctgt aacagtgaca   6660

acaggaagaa aagcaatgac cattgtactt tcgtttatat tctttgctaa accattcacg   6720

tttcagtatg tatggtctgg tttgttagtt gtccttggta tatttcttaa tgtttacagc   6780

aaaaatatgg ataaaataag actaccatca ctgtatgatt tgataaacaa atcagtggaa   6840

gcaagaaagt caaggacgct ggcacagact gtatagacag tgattgtcct atttaaaata   6900

gaattttaag ggaacaatca tcaattaatt aactttccaa agggactgat aaaaaccaaa   6960

ggatctggag gcattgctat cccatttgtg gacagatttc atatgaagtt gttttgcggt   7020

gtcagccttt tcttcagagc atttgtttga ctgacttcca aagcaatcaa gagagccacg   7080

tctagcagac tttacaataa aatgtcaata tgaaggactg taattcctag cagtttattg   7140

agaatttcac tggaaatgga ccatgtgttg caagactaat tggctataat tatatcctat   7200

caaagaaatc gatacgtaat agcagattgt tttatattca ttccattttg atggtgttat   7260

ttaaattgat tctctgttat aagagtaaac tgatgagttg aagtctggag agaataacat   7320

tcattataaa taaaattatt ctgtgatctt ttttcaa                            7357


<210>  3085
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  3085

Met Lys Val Leu Lys Ile Val Phe Tyr Arg Ile Pro Gly Lys Thr Tyr 
1               5                   10                  15


Met Ile Ile Ala Phe Leu Thr Val Gly Thr Met Gly Leu Ser Asn Thr 
            20                  25                  30


Ser Leu Gly Tyr Leu Asn Tyr Pro Thr Gln Val Ile Phe Lys Cys Cys 
        35                  40                  45


Lys Leu Ile Pro Val Met Leu Gly Gly Val Phe Ile Gln Gly Lys Arg 
    50                  55                  60


Tyr Asn Val Ala Asp Val Ser Ala Ala Ile Cys Met Ser Leu Gly Leu 
65                  70                  75                  80


Ile Trp Phe Thr Leu Ala Asp Ser Thr Thr Ala Pro Asn Phe Asn Leu 
                85                  90                  95


Thr Gly Val Val Leu Ile Ser Leu Ala Leu Cys Ala Asp Ala Val Ile 
            100                 105                 110


Gly Asn Val Gln Glu Lys Ala Met Lys Leu His Asn Ala Ser Asn Ser 
        115                 120                 125


Glu Met Asn Ile Thr Thr Ser Ser Tyr Ser Gly Val Phe Ile Phe Pro 
    130                 135                 140


Asn Lys Leu Lys Ile Pro Leu Val Leu 
145                 150


<210>  3086
<211>  2206
<212>  DNA
<213>  Homo sapiens

<400>  3086
gcacgcgcgc agggacacat aggcggaagt ggcctgcggg cgccggagtt gagagtgctt     60

tccggggagg cgaccgccgc ggtggaaagt gcaggagtgg gcgaggagga ggaggaagag    120

gaggtgatgg cgacggacca ggggaggggg agatgctccg tctagctcag acgccacgca    180

ggctgccgtc acccttccgg gtgacatacc ggccttgggg tacgcgtgcc ttcggggcct    240

ttcctgtgtt tgggacccag atctcctctc ctccagaaaa ccttgacact gcccatcttc    300

ctcatccaga aggagcgttc gaggaatgga tgaggccatg attgattccg gagcgcagtt    360

aatcaaggca taatggcatg gacttgacac agcaagcaaa agacatacag aacataacag    420

tccaggaaac caacaaaaat aactctgaaa gcattgaatg cagcaaaata acaatggatc    480

tcaagttcaa caattccagg aaatatattt ctatcactgt gccatccaaa acccaaacaa    540

tgtcaccaca catcaagtca gttgacgacg ttgtggtact tggcatgaat ctcagcaagt    600

ttaacaaact tactcagttt ttcatatgtg ttgctggagt ttttgtattt tacctaattt    660

atgggtattt acaggaatta atattttcag tggagggttt taagtcctgt ggctggtacc    720

ttaccttagt gcagtttgcc ttttactcca tatttggcct aatagaactt cagcttattc    780

aggacaaaag gaggagaata ccaggaaaaa cctacatgat aatagctttt ctaactgtgg    840

gtactatggg gttatcaaac acttccttgg gctacctgaa ttaccctacc caagtcatct    900

tcaagtgctg caaattgatt cctgttatgc taggaggagt ttttattcaa ggaaagcgtt    960

ataatgttgc agatgtgtct gctgccatat gtatgagcct tggcctgata tggtttaccc   1020

tcgctgacag cacaactgca ccaaatttca acctgacggg tgtggtgctt atttccctgg   1080

cactatgtgc agatgccgtc attggaaatg ttcaagagaa agctatgaaa cttcataatg   1140

cttctaattc tgaaatgaat attactacca gtagttattc tggggtgttt atattcccaa   1200

ataaactaaa aatcccattg gtattgtgat tggtatggca ttgaattata aattaattta   1260

gggagaatgg catcttgatt atttcagtcc aagaataagg tattgtattc gtattcaatt   1320

ggttttgtat acattttact gggattgaca tgcactagtg gattaggccc tgcagtaaca   1380

ttttgtgcaa agaatccagt tcggacctat ggttatgcgt tccttttttc cctcactgga   1440

tattttggaa tctcctttgt tctggctttg attaaaattt ttggtgcact tattgctgta   1500

acagtgacaa caggaagaaa agcaatgacc attgtacttt cgtttatatt ctttgctaaa   1560

ccattcacgt ttcagtatgt atggtctggt ttgttagttg tccttggtat atttcttaat   1620

gtttacagca aaaatatgga taaaataaga ctaccatcac tgtatgattt gataaacaaa   1680

tcagtggaag caagaaagtc aaggacgctg gcacagactg tatagacagt gattgtccta   1740

tttaaaatag aattttaagg gaacaatcat caattaatta actttccaaa gggactgata   1800

aaaaccaaag gatctggagg cattgctatc ccatttgtgg acagatttca tatgaagttg   1860

ttttgcggtg tcagcctttt cttcagagca tttgtttgac tgacttccaa agcaatcaag   1920

agagccacgt ctagcagact ttacaataaa atgtcaatat gaaggactgt aattcctagc   1980

agtttattga gaatttcact ggaaatggac catgtgttgc aagactaatt ggctataatt   2040

atatcctatc aaagaaatcg atacgtaata gcagattgtt ttatattcat tccattttga   2100

tggtgttatt taaattgatt ctctgttata agagtaaact gatgagttga agtctggaga   2160

gaataacatt cattataaat aaaattattc tgtgatcttt tttcaa                  2206


<210>  3087
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  3087

Met Asp Leu Thr Gln Gln Ala Lys Asp Ile Gln Asn Ile Thr Val Gln 
1               5                   10                  15


Glu Thr Asn Lys Asn Asn Ser Glu Ser Ile Glu Cys Ser Lys Ile Thr 
            20                  25                  30


Met Asp Leu Lys Phe Asn Asn Ser Arg Lys Tyr Ile Ser Ile Thr Val 
        35                  40                  45


Pro Ser Lys Thr Gln Thr Met Ser Pro His Ile Lys Ser Val Asp Asp 
    50                  55                  60


Val Val Val Leu Gly Met Asn Leu Ser Lys Phe Asn Lys Leu Thr Gln 
65                  70                  75                  80


Phe Phe Ile Cys Val Ala Gly Val Phe Val Phe Tyr Leu Ile Tyr Gly 
                85                  90                  95


Tyr Leu Gln Glu Leu Ile Phe Ser Val Glu Gly Phe Lys Ser Cys Gly 
            100                 105                 110


Trp Tyr Leu Thr Leu Val Gln Phe Ala Phe Tyr Ser Ile Phe Gly Leu 
        115                 120                 125


Ile Glu Leu Gln Leu Ile Gln Asp Lys Arg Arg Arg Ile Pro Gly Lys 
    130                 135                 140


Thr Tyr Met Ile Ile Ala Phe Leu Thr Val Gly Thr Met Gly Leu Ser 
145                 150                 155                 160


Asn Thr Ser Leu Gly Tyr Leu Asn Tyr Pro Thr Gln Val Ile Phe Lys 
                165                 170                 175


Cys Cys Lys Leu Ile Pro Val Met Leu Gly Gly Val Phe Ile Gln Gly 
            180                 185                 190


Lys Arg Tyr Asn Val Ala Asp Val Ser Ala Ala Ile Cys Met Ser Leu 
        195                 200                 205


Gly Leu Ile Trp Phe Thr Leu Ala Asp Ser Thr Thr Ala Pro Asn Phe 
    210                 215                 220


Asn Leu Thr Gly Val Val Leu Ile Ser Leu Ala Leu Cys Ala Asp Ala 
225                 230                 235                 240


Val Ile Gly Asn Val Gln Glu Lys Ala Met Lys Leu His Asn Ala Ser 
                245                 250                 255


Asn Ser Glu Met Asn Ile Thr Thr Ser Ser Tyr Ser Gly Val Phe Ile 
            260                 265                 270


Phe Pro Asn Lys Leu Lys Ile Pro Leu Val Leu 
        275                 280


<210>  3088
<211>  512
<212>  DNA
<213>  Homo sapiens

<400>  3088
agtggcctgc gggcgccgga gttgagagtg ctttccgggg aggcgaccgc cgcggtggaa     60

agtgcaggag tgggcgagga ggaggaggaa gaggaggact tgacacagca agcaaaagac    120

atacagaaca taacagtcca ggaaaccaac aaaaataact ctgaaagcat tgaatgcagc    180

aaaataacaa tggatctcaa gttcaacaat tccaggaaat atatttctat cactgtgcca    240

tccaaaaccc aaacaatgtc accacacatc aagtcagttg acgacgttgt ggtacttggc    300

atgaatctca gcaagtttaa caaacttact cagtttttca tatgtgttgc tggagttttt    360

gtattttacc taatttatgg gtatttacag gaattaatat tttcagtgga gggttttaag    420

tcctgtggct ggtaccttac cttagtgcag tttgcctttt actccatatt tggcctaata    480

gaacttcagc ttattcagga caaaaggagg ag                                  512


<210>  3089
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  3089

Met Asp Leu Lys Phe Asn Asn Ser Arg Lys Tyr Ile Ser Ile Thr Val 
1               5                   10                  15


Pro Ser Lys Thr Gln Thr Met Ser Pro His Ile Lys Ser Val Asp Asp 
            20                  25                  30


Val Val Val Leu Gly Met Asn Leu Ser Lys Phe Asn Lys Leu Thr Gln 
        35                  40                  45


Phe Phe Ile Cys Val Ala Gly Val Phe Val Phe Tyr Leu Ile Tyr Gly 
    50                  55                  60


Tyr Leu Gln Glu Leu Ile Phe Ser Val Glu Gly Phe Lys Ser Cys Gly 
65                  70                  75                  80


Trp Tyr Leu Thr Leu Val Gln Phe Ala Phe Tyr Ser Ile Phe Gly Leu 
                85                  90                  95


Ile Glu Leu Gln Leu Ile Gln Asp Lys Arg 
            100                 105


<210>  3090
<211>  569
<212>  DNA
<213>  Homo sapiens

<400>  3090
acataggcgg aagtggcctg cgggcgccgg agttgagagt gctttccggg gaggcgaccg     60

ccgcggtgga aagtgcagga gtgggcgagg aggaggagga agaggaggcc atgattgatt    120

ccggagcgca gttaatcaag gcataatggc atggacttga cacagcaagc aaaagacata    180

cagaacataa cagtccagga aaccaacaaa aataactctg aaagcattga atgcagcaaa    240

ataacaatgg atctcaagtt caacaattcc aggaaatata tttctatcac tgtgccatcc    300

aaaacccaaa caatgtcacc acacatcaag tcagttgacg acgttgtggt acttggcatg    360

aatctcagca agtttaacaa acttactcag tttttcatat gtgttgctgg agtttttgta    420

ttttacctaa tttatgggta tttacaggaa ttaatatttt cagtggaggg ttttaagtcc    480

tgtggctggt accttacctt agtgcagttt gccttttact ccatatttgg cctaatagaa    540

cttcagctta ttcaggacaa aaggaggag                                      569


<210>  3091
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  3091

Met Asp Leu Thr Gln Gln Ala Lys Asp Ile Gln Asn Ile Thr Val Gln 
1               5                   10                  15


Glu Thr Asn Lys Asn Asn Ser Glu Ser Ile Glu Cys Ser Lys Ile Thr 
            20                  25                  30


Met Asp Leu Lys Phe Asn Asn Ser Arg Lys Tyr Ile Ser Ile Thr Val 
        35                  40                  45


Pro Ser Lys Thr Gln Thr Met Ser Pro His Ile Lys Ser Val Asp Asp 
    50                  55                  60


Val Val Val Leu Gly Met Asn Leu Ser Lys Phe Asn Lys Leu Thr Gln 
65                  70                  75                  80


Phe Phe Ile Cys Val Ala Gly Val Phe Val Phe Tyr Leu Ile Tyr Gly 
                85                  90                  95


Tyr Leu Gln Glu Leu Ile Phe Ser Val Glu Gly Phe Lys Ser Cys Gly 
            100                 105                 110


Trp Tyr Leu Thr Leu Val Gln Phe Ala Phe Tyr Ser Ile Phe Gly Leu 
        115                 120                 125


Ile Glu Leu Gln Leu Ile Gln Asp Lys Arg 
    130                 135


<210>  3092
<211>  1147
<212>  DNA
<213>  Homo sapiens

<400>  3092
gctgccccag cggtaggggg cctggggcgg agaagccgct acagccgcgg ccgggcgacg     60

ctgacatctg gcatccctgg ggtctcagag acacgggtgg acagcgacga gggccttgtg    120

gccgccgtgt cgcaggacgc gccgccgccc gcgctcaccg ccgtccgcgc cagccgcccc    180

gagccgactg cccttctgcc cccaagatgt ggcacagcgt cgggctgact ctgcttgtgt    240

tcgtggccac gctgctgatc gtcctgctgc tgatggtgtg cggttggtat tttgtatggc    300

atcttttttt atcaaaattc aagtttctcc gggaactggt gggagacaca ggatcccaag    360

agggagatca tgagccttca gggtctgaaa ctgaagaaga cacttcctcc tctccacaca    420

gaatcagatc cgctcgccaa aggagggcac ctgctgatga aggccacaga cccctgacat    480

agtcctgtac ttgtgaagga tgaaaaggca gttgccagct tctgtctttt actgacttcg    540

ctttgaaatt tactaatgac tgaagaacat ttgtattgga ttttaagtcg aattttaaaa    600

aagatttaca tgtaagccat ataaaaataa agggaactga aaccaaattg gactattata    660

aatttcatct taaagataat cttttgtttc accagctttc tacttataca cttattcctt    720

ggcttttggg cttattttct tgcactggtg cagatctggt aaacattaaa ggcttgaaaa    780

accatatttt gttagcccta aaatgtacat ttttcttccc attttaactt atctgaaatt    840

gggatgcatc tcattactgt caaccaggtg atagtcatgt aacgctccta ccgtgtgcat    900

gtgtgaattt acagcttgtc atcgtgtcat ccctttaacc aacatgtgtt ttgttggtat    960

caaatgtgtc aggtttaatt gacattttaa aatgtcttca aaaagatcac actatgattc   1020

agcattgaaa cgaaaagtta ttgtgtatgc agaaaagcat ggaaacagag cagcagggcg   1080

tacatttgat attagtgaag caaatattcg tcgctggaga aatgatcgca attccatatt   1140

ttcctgc                                                             1147


<210>  3093
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  3093

Met Trp His Ser Val Gly Leu Thr Leu Leu Val Phe Val Ala Thr Leu 
1               5                   10                  15


Leu Ile Val Leu Leu Leu Met Val Cys Gly Trp Tyr Phe Val Trp His 
            20                  25                  30


Leu Phe Leu Ser Lys Phe Lys Phe Leu Arg Glu Leu Val Gly Asp Thr 
        35                  40                  45


Gly Ser Gln Glu Gly Asp His Glu Pro Ser Gly Ser Glu Thr Glu Glu 
    50                  55                  60


Asp Thr Ser Ser Ser Pro His Arg Ile Arg Ser Ala Arg Gln Arg Arg 
65                  70                  75                  80


Ala Pro Ala Asp Glu Gly His Arg Pro Leu Thr 
                85                  90


<210>  3094
<211>  1965
<212>  DNA
<213>  Homo sapiens

<400>  3094
cggagaagcc gctacagccg cggccgggcg acgctgacat ctggcatccc tggggtctca     60

gagacacggg tggacagcga cgagggcctt gtggccgccg tgtgtacccg tgcttaccct    120

ctgtcctccc tacaggcgcg cggcgtccgc catggaagcg catccgaccg ctggggtctc    180

tgggtgccgc ggcctcggct ctccggggcg atgagggact agaggcgccc tgaggcccgc    240

ctgcctcccg cgctctggcc accccggcgg gaaaaggatc gggcgggcgg gcggtcccac    300

agtgcccgcc tttgcgccgc cccaccccct gggggcgctg ccgagggggc gccagccgcc    360

catgccgccc cggcgcccag ccgcgcctgg cgcccgccgc tgaagcgcag gacgcgccgc    420

cgcccgcgct caccgccgtc cgcgccagcc gccccgagcc gactgccctt ctgcccccaa    480

gatgtggcac agcgtcgggc tgactctgct tgtgttcgtg gccacgctgc tgatcgtcct    540

gctgctgatg gtgtgcggtt ggtattttgt atggcatctt tttttatcaa aattcaagtt    600

tctccgggaa ctggtgggag acacaggatc ccaagaggga gatcatgagc cttcagggtc    660

tgaaactgaa gaagacactt cctcctctcc acacagaatc agatccgctc gccaaaggag    720

ggcacctgct gatgaaggcc acagacccct gacatagtcc tgtacttgtg aaggatgaaa    780

aggcagttgc cagcttctgt cttttactga cttcgctttg aaatttacta atgactgaag    840

aacatttgta ttggatttta agtcgaattt taaaaaagat ttacatgtaa gccatataaa    900

aataaaggga actgaaacca aattggacta ttataaattt catcttaaag ataatctttt    960

gtttcaccag ctttctactt atacacttat tccttggctt ttgggcttat tttcttgcac   1020

tggtgcagat ctggtaaaca ttaaaggctt gaaaaaccat attttgttag ccctaaaatg   1080

tacatttttc ttcccatttt aacttatctg aaattgggat gcatctcatt actgtcaacc   1140

aggtgatagt catgtaacgc tcctaccgtg tgcatgtgtg aatttacagc ttgtcatcgt   1200

gtcatccctt taaccaacat gtgttttgtt ggtatcaaat gtgtcaggtt taattgacat   1260

tttaaaatgt cttcaaaaag atcacactat gattcagcat tgaaacgaaa agttattgtg   1320

tatgcagaaa agcatggaaa cagagcagca gggcgtacat ttgatattag tgaagcaaat   1380

attcgtcgct ggagaaatga tcgcaattcc atattttcct gcaaagcaac aacaaaatgt   1440

tttacgggac ctaagaaagg taggtaccca caagtagatg aagctgtact acgtttcgtc   1500

agtgagacac gtgcaaaagg attgcctatc acacgccaag caatgcaatt gaaggcagga   1560

gaagttgcca aaaccctagg aattgatgaa acaaaattca aagccacaag aggctggtgt   1620

gaccgattca tgcgtcgagc aggactatca ttaaggcatc aaacatcgtt ttgtcccaag   1680

ctccccactg ccattaaaca gaagacagtg ttggagcact ctttcaagaa gtgctgcata   1740

accagtactc ttgacaacac cgggagagac gttctgtgga aaaatgcaga catcaatgac   1800

tgtggtttga aaagtgattc agaagagttg gattcagaat atgaagttat aattataact   1860

taaccaattt atttcacaca ttttctttac atatgcacaa gattgatgtg ataaaaatct   1920

gtttaactca aagcgctgtt tcaataaata taaacatttt ctgtg                   1965


<210>  3095
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  3095

Met Trp His Ser Val Gly Leu Thr Leu Leu Val Phe Val Ala Thr Leu 
1               5                   10                  15


Leu Ile Val Leu Leu Leu Met Val Cys Gly Trp Tyr Phe Val Trp His 
            20                  25                  30


Leu Phe Leu Ser Lys Phe Lys Phe Leu Arg Glu Leu Val Gly Asp Thr 
        35                  40                  45


Gly Ser Gln Glu Gly Asp His Glu Pro Ser Gly Ser Glu Thr Glu Glu 
    50                  55                  60


Asp Thr Ser Ser Ser Pro His Arg Ile Arg Ser Ala Arg Gln Arg Arg 
65                  70                  75                  80


Ala Pro Ala Asp Glu Gly His Arg Pro Leu Thr 
                85                  90


<210>  3096
<211>  1412
<212>  DNA
<213>  Homo sapiens

<400>  3096
tgtaggttgg tattttgtat ggcatctttt tttatcaaaa ttcaagtttc tccgggaact     60

ggtgggagac acaggatccc aagagggaga tcatgagcct tcagggtctg aaactgaaga    120

agacacttcc tcctctccac acagaatcag atccgctcgc caaaggaggg cacctgctga    180

tgaaggccac agacccctga catagtcctg tacttgtgaa ggatgaaaag gcagttgcca    240

gcttctgtct tttactgact tcgctttgaa atttactaat gactgaagaa catttgtatt    300

ggattttaag tcgaatttta aaaaagattt acatgtaagc catataaaaa taaagggaac    360

tgaaaccaaa ttggactatt ataaatttca tcttaaagat aatcttttgt ttcaccagct    420

ttctacttat acacttattc cttggctttt gggcttattt tcttgcactg gtgcagatct    480

ggtaaacatt aaaggcttga aaaaccatat tttgttagcc ctaaaatgta catttttctt    540

cccattttaa cttatctgaa attgggatgc atctcattac tgtcaaccag gtgatagtca    600

tgtaacgctc ctaccgtgtg catgtgtgaa tttacagctt gtcatcgtgt catcccttta    660

accaacatgt gttttgttgg tatcaaatgt gtcaggttta attgacattt taaaatgtct    720

tcaaaaagat cacactatga ttcagcattg aaacgaaaag ttattgtgta tgcagaaaag    780

catggaaaca gagcagcagg gcgtacattt gatattagtg aagcaaatat tcgtcgctgg    840

agaaatgatc gcaattccat attttcctgc aaagcaacaa caaaatgttt tacgggacct    900

aagaaaggta ggtacccaca agtagatgaa gctgtactac gtttcgtcag tgagacacgt    960

gcaaaaggat tgcctatcac acgccaagca atgcaattga aggcaggaga agttgccaaa   1020

accctaggaa ttgatgaaac aaaattcaaa gccacaagag gctggtgtga ccgattcatg   1080

cgtcgagcag gactatcatt aaggcatcaa acatcgtttt gtcccaagct ccccactgcc   1140

attaaacaga agacagtgtt ggagcactct ttcaagaagt gctgcataac cagtactctt   1200

gacaacaccg ggagagacgt tctgtggaaa aatgcagaca tcaatgactg tggtttgaaa   1260

agtgattcag aagagttgga ttcagaatat gaagttataa ttataactta accaatttat   1320

ttcacacatt ttctttacat atgcacaaga ttgatgtgat aaaaatctgt ttaactcaaa   1380

gcgctgtttc aataaatata aacattttct gt                                 1412


<210>  3097
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  3097

Met Ser Ser Lys Arg Ser His Tyr Asp Ser Ala Leu Lys Arg Lys Val 
1               5                   10                  15


Ile Val Tyr Ala Glu Lys His Gly Asn Arg Ala Ala Gly Arg Thr Phe 
            20                  25                  30


Asp Ile Ser Glu Ala Asn Ile Arg Arg Trp Arg Asn Asp Arg Asn Ser 
        35                  40                  45


Ile Phe Ser Cys Lys Ala Thr Thr Lys Cys Phe Thr Gly Pro Lys Lys 
    50                  55                  60


Gly Arg Tyr Pro Gln Val Asp Glu Ala Val Leu Arg Phe Val Ser Glu 
65                  70                  75                  80


Thr Arg Ala Lys Gly Leu Pro Ile Thr Arg Gln Ala Met Gln Leu Lys 
                85                  90                  95


Ala Gly Glu Val Ala Lys Thr Leu Gly Ile Asp Glu Thr Lys Phe Lys 
            100                 105                 110


Ala Thr Arg Gly Trp Cys Asp Arg Phe Met Arg Arg Ala Gly Leu Ser 
        115                 120                 125


Leu Arg His Gln Thr Ser Phe Cys Pro Lys Leu Pro Thr Ala Ile Lys 
    130                 135                 140


Gln Lys Thr Val Leu Glu His Ser Phe Lys Lys Cys Cys Ile Thr Ser 
145                 150                 155                 160


Thr Leu Asp Asn Thr Gly Arg Asp Val Leu Trp Lys Asn Ala Asp Ile 
                165                 170                 175


Asn Asp Cys Gly Leu Lys Ser Asp Ser Glu Glu Leu Asp Ser Glu Tyr 
            180                 185                 190


Glu Val Ile Ile Ile Thr 
        195


<210>  3098
<211>  2771
<212>  DNA
<213>  Homo sapiens

<400>  3098
agtgatacat atggtgcatc ttaacaattg gtagtgtctt aggttaaatt aaaaatggta     60

gcttgtaaat ttatttttct ttttaagata gcagttattt attggggaat ttgattctga    120

ctcttacaat gttaaacttg taatcctgtg tgaaacacat gtttttgggg gggagggggt    180

aaccaagatt tcagggtagt aacttaggaa tctaagaact atcttctact ttaggaagag    240

tgggattagt tactcccttt gtataggagg actttatgct caaggaatgt gttgtggaga    300

aaaacacttc ttcacaaaca attcagtgac aagacctcaa aggtaatgcg tattgaggaa    360

aacagtagtg ggtgaaaatt cccgcttagc tgtaaaatga ctctcttgcc aggtttccgt    420

gtttgtctca actgaactct gggctgagtg tttaccaggg agaagagatg tgaattaaac    480

aaccttcctg tttagtgtta cctgctttgt acaagaatga agtgcaaagc caacttactt    540

tattaatcca agttcttttt atgtttttct taacctttat taaggactag tcatcacaaa    600

atatctattt aacctctatt ttatgatggt gtgttattat gtttgatacc tcatacttct    660

tgcttagagt tttgtttaac agttcactgg ctctgtccca atgtttgtga tgaacacctt    720

tttgctatat tgtagctctt ggagatacta aaagagaatt cacagaacat aactttagtt    780

ttatgtgttt gctaggggaa gatttcctag cagctgagag caaggcacag tctctgtctt    840

catttcttta ttagatacaa ttttctattt ttatgtgatt ttgggggcat tatttggtac    900

tgggaggata tttaaattag atttttcata gtctattgtt ttgaactatg gattctgttt    960

tatggtggat acctaaggtt tatataatag ttgctggaaa acttaaagta gctggtgagc   1020

ttcctgttat gtcactatta aagaatgatg gctgatgtaa ctctgcccct gaaatctaca   1080

agggtcatgc ccaaattaat acaggttaac ctttgtagag gtatatatgt tggcattatt   1140

tattgacatt tatgcttcaa gcatgtctta ttttatgtaa ttttaagaaa tactctattt   1200

aacttgtgaa atatacctaa aagcatacta gttagctctt agactctcac ttagggaggg   1260

taaagaaaca tcactgatgc caatatgaag atctataaac aaatcctttg tttagaactt   1320

ttttctcttc gtgcacctca caacacactt accatggtac atatttctta atgccactaa   1380

gaaaggcaag atagtgaacg cagaattatt tatgtggtat agtgtttgtt ttcctgtttt   1440

agtgcttttg tagctaaaac ttactggaac tgcatcacaa ctacatttgc agtctcagtg   1500

ggaggtggac tagcctgtgg ttaattttag agcttaaaag tttataagca ttaaaaacac   1560

atacatgtat tagaatcttg tctaacccct cacaaaggat gatggtgatc agcatgccat   1620

cttttgaaga ttaattctaa aattgaggac tctggtaggt tgttttattt ccttcccaac   1680

cagccattca tttccaattg ttctgccttt gaaacttttt gtgaaaattg cctgtaccaa   1740

ttgcattggt tgcgttgctc tgatttaaat gccaaaaaca ctaaatattt gtgtagtgct   1800

gttaaatgag gtttttgata tttccatcaa aatgaatata aaattcactt gatggatttt   1860

gtagtgatgt tttcacagtt gaaacaaaca tattgctgtg cggtggacag ccacttcaca   1920

gacatgcaga cccatttctt tagagatatt aggtttaaaa cccattttaa ttttattttg   1980

ctgaaggttt ggaatatata aagtaatgga ttcacaaaat atgatatctt aaaacatgtt   2040

gaaagatttg aaagtggtgc atttttactt ttaagagcag caatctttga aattagtcaa   2100

caatgcagtc ttttttaaaa gtcagttttc tcaagtagta tgttgtaacg taagatgtaa   2160

ctgatataac tagattttga ctggtaaact taaagtgctt tttatatttg aggttgactt   2220

taaaaagcca ttgagcagtc ctcagaggtt atggactctc aagcgactaa tggaatagtg   2280

ttctgttgtg aagtctagaa ctaaagcacc ttgtattgtc tgcttctaaa gtgtcctata   2340

gtttttaact taaagtgtaa agagtaacat tttatcttat gtcaattaaa gttacatttt   2400

tcatttgttg gtgtacatgt gctacctgtt ttatggggaa tgtttaacac gatcctccaa   2460

gttggttcta tgcataacca ttcaccaaat actgctgctg tgattccttg aaggaaatat   2520

tctgtggtct gctatgatgc attgccatct tgctgcttga caataggttt ataaataatt   2580

agaattacgt gttttaatag tacctttgta tatataacaa gatgtaaaat taaagatgag   2640

gaatgtgtgt aaatgatcat tcactgtttt tgttttaaaa ctggtcagta ctatgaagct   2700

tctgtggttt gtatgatgtt ttaactttca ctttaaactg catagaataa attaaattga   2760

aaacaacaaa a                                                        2771


<210>  3099
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  3099

Met Asp Phe Val Val Met Phe Ser Gln Leu Lys Gln Thr Tyr Cys Cys 
1               5                   10                  15


Ala Val Asp Ser His Phe Thr Asp Met Gln Thr His Phe Phe Arg Asp 
            20                  25                  30


Ile Arg Phe Lys Thr His Phe Asn Phe Ile Leu Leu Lys Val Trp Asn 
        35                  40                  45


Ile 



<210>  3100
<211>  693
<212>  DNA
<213>  Homo sapiens

<400>  3100
gtgtctggtg gtctcctgac tgccaggcag gccagagaaa attaggggta tgttttcatt     60

taacatcatt ccctgctgac tcttgtctct ctggaaaatt gacagttagg agacaaaaac    120

gttgccatct ccagcaaaga gcgcttgaac agctgggcat ttctagaaag gaatgggcct    180

ggaagacctg gctaaaacct ttgaatcatt tcctgccaac atttggccgt gacccatttt    240

ggaaggtcac tcagctattg gtctgaagaa gccttttttt tttctatttg gccttctttg    300

gaagccaatt tatcgtctga gttcttctcc tgtaatctga actacaggtt gcaggttctg    360

aactacctga agccatgcaa gtcataacac atcattactg acttctagct ctttccttca    420

agtctctggc attgcagatg ttatttctgt cctaagaaga gcaagaggag ctgcaatatg    480

aaaccagaaa acagacacac ttcatttctc tctgctgttg gtgttttctg gggagaccag    540

tggagtcact ctgggcagga ctgaggggga cctgggtata tgaccaagcc ctggacagtt    600

catgtgaagg agcaggaccc agcttccagg tcaggaggga aacatgcctg acctttgtgc    660

tgctctgcca ggtgaggtgt cctttcctct cct                                 693


<210>  3101
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  3101

Val Trp Trp Ser Pro Asp Cys Gln Ala Gly Gln Arg Lys Leu Gly Val 
1               5                   10                  15


Cys Phe His Leu Thr Ser Phe Pro Ala Asp Ser Cys Leu Ser Gly Lys 
            20                  25                  30


Leu Thr Val Arg Arg Gln Lys Arg Cys His Leu Gln Gln Arg Ala Leu 
        35                  40                  45


Glu Gln Leu Gly Ile Ser Arg Lys Glu Trp Ala Trp Lys Thr Trp Leu 
    50                  55                  60


Lys Pro Leu Asn His Phe Leu Pro Thr Phe Gly Arg Asp Pro Phe Trp 
65                  70                  75                  80


Lys Val Thr Gln Leu Leu Val 
                85


<210>  3102
<211>  4536
<212>  DNA
<213>  Homo sapiens

<400>  3102
acaacagtga gctcagagac ttgagggagg cgctgcgact gacaagcggc tctgcccggg     60

accttctcgc tttcatctag cgctgcactc aatggagggg cgggcaccgc agtgcttaat    120

gctgtcttaa ctagtgtagg aaaacggctc aacccaccgc tgccgaaatg aagtataaga    180

atcttatggc aagggcctta tatgacaatg tcccagagtg tgccgaggaa ctggcctttc    240

gcaagggaga catcctgacc gtcatagagc agaacacagg gggactggaa ggatggtggc    300

tgtgctcatt acacggtcgg caaggcattg tcccaggcaa ccgggtgaag cttctgattg    360

gtcccatgca ggagactgcc tccagtcacg agcagcctgc ctctggactg atgcagcaga    420

cctttggcca acagaagctc tatcaagtgc caaacccaca ggctgctccc cgagacacca    480

tctaccaagt gccaccttcc taccaaaatc agggaattta ccaagtcccc actggccacg    540

gcacccaaga acaagaggta tatcaggtgc caccatcagt gcagagaagc attgggggaa    600

ccagtgggcc ccacgtgggt aaaaaggtga taacccccgt gaggacaggc catggctacg    660

tatacgagta cccatccaga taccaaaagg acgtctatga tatccctcct tctcatacca    720

ctcaaggggt atacgacatc cctccctcat cagcaaaagg ccctgtgttt tcagttccag    780

tgggagagat aaaacctcaa ggggtgtatg acatcccgcc tacaaaaggg gtatatgcca    840

ttccgccctc tgcttgccgg gatgaagcag ggcttaggga aaaagactat gacttccccc    900

ctcccatgag acaagctgga aggccggacc tcagaccgga gggggtttat gacattcctc    960

caacctgcac caagccagca gggaaggacc ttcatgtaaa atacaactgt gacattccag   1020

gagctgcaga accggtggct cgaaggcacc agagcctgtc cccgaatcac ccacccccgc   1080

aactcggaca gtcagtgggc tctcagaacg acgcatatga tgtcccccga ggcgttcagt   1140

ttcttgagcc accagcagaa accagtgaga aagcaaaccc ccaggaaagg gatggtgttt   1200

atgatgtccc tctgcataac ccgccagatg ctaaaggctc tcgggacttg gtggatggga   1260

tcaaccgatt gtctttctcc agtacaggca gcacccggag taacatgtcc acgtcttcca   1320

cctcctccaa ggagtcctca ctgtcagcct ccccagctca ggacaaaagg ctcttcctgg   1380

atccagacac agctattgag agacttcagc ggctccagca ggcccttgag atgggtgtct   1440

ccagcctaat ggcactggtc actaccgact ggcggtgtta cggatatatg gaaagacaca   1500

tcaatgaaat acgcacagca gtggacaagg tggagctgtt cctgaaggag tacctccact   1560

ttgtcaaggg agctgttgca aatgctgcct gcctcccgga actcatcctc cacaacaaga   1620

tgaagcggga gctgcaacga gttgaagact cccaccagat cctgagtcaa accagccatg   1680

acttaaatga gtgcagctgg tccctgaata tcttggccat caacaagccc cagaacaagt   1740

gtgacgatct ggaccggttt gtgatggtgg caaagacggt gcccgatgac gccaagcagc   1800

tcaccacaac catcaacacc aacgcagagg ccctcttcag acccggccct ggcagcttgc   1860

atctgaagaa tgggccggag agcatcatga actcaacgga gtacccacac ggtggctccc   1920

agggacagct gctgcatcct ggtgaccaca aggcccaggc ccacaacaag gcactgcccc   1980

caggcctgag caaggagcag gcccctgact gtagcagcag tgatggttct gagaggagct   2040

ggatggatga ctacgattac gtccacctac agggtaagga ggagtttgag aggcaacaga   2100

aagagctatt ggaaaaagag aatatcatga aacagaacaa gatgcagctg gaacatcatc   2160

agctgagcca gttccagctg ttggaacaag agattacaaa gcccgtggag aatgacatct   2220

cgaagtggaa gccctctcag agcctaccca ccacaaacag tggcgtgagt gctcaggatc   2280

ggcagttgct gtgcttctac tatgaccaat gtgagaccca tttcatttcc cttctcaacg   2340

ccattgacgc actcttcagt tgtgtcagct cagcccagcc cccgcgaatc ttcgtggcac   2400

acagcaagtt tgtcatcctc agtgcacaca aactggtgtt cattggagac acgctgacac   2460

ggcaggtgac tgcccaggac attcgcaaca aagtcatgaa ctccagcaac cagctctgcg   2520

agcagctcaa gaccatagtc atggcaacca agatggccgc cctccattac cccagcacca   2580

cggccctgca ggaaatggtg caccaagtga cagacctttc tagaaatgcc cagctgttca   2640

agcgctcttt gctggagatg gcaacgttct gagaagaaaa aaaagaggaa ggggactgcg   2700

ttaacggtta ctaaggaaaa ctggaaatac tgtctggttt ttgtaaatgt tatctatttt   2760

tgtagatatt ttatataaaa atgaaatatt ttaacatttt atgggtcagt caactttcag   2820

aaattcaggg agctggagag ggaaatcttt ttttttcccc ctgagtggtt cttatgtata   2880

catagaagta tctgagacat aaactgtaca gaaaacttgt ccacgtgctt ttgtatgccc   2940

atgtattcat gtttgtttgt agatgtttgt ctgatgcatt tcattaaaaa aaaaaccatg   3000

aattacgaag caccttagta agcaccttct aatgctgcat tttttttgtt gttgttaaaa   3060

acataccagc tggttataat attgttctcc acgtccttgt gatgattctg agcctggcac   3120

tcccaaatct gggaagcata gtttatttgc aagtgttcac cttccaaatc atgaggcata   3180

gcatgactta ttcttgtttg gaaaactctt ttcaaaactg accatcttaa acacatgatg   3240

gccaagtgcc caaaagccct cttgcggagc aaatttcaga atatatatgt ggatccaagc   3300

tctgatagtt caggtgctgg agggaagaga gacctgtgtg tttagaggcc aggaccacag   3360

ttaggattgg gttgtttcaa tactgagaga cagctacaat aaaaggagag caattgcctc   3420

cctggggctg ttcaatcttc tgcatttgtg agtggttcag tcatgaggtt ttccaaaaga   3480

tgtttttaga gttgtaaaaa ccatatttgc agcaaagatt tacaaaggcg tatcagacta   3540

tgattgttca ccaaaatagg ggaatggttt gatccgccag ttgcaagtag aggcctttct   3600

gactcttaat attcactttg gtgctactac ccccattacc tgagggaaac tggccaggtc   3660

cttgatcatg gaactataga gctaccagga catatcctgc tctctaaggg aatttattgc   3720

tatcttgcac cttctttaaa actcacatat gcagacctga cactcaagag tggctagcta   3780

cacagagtcc atctaatttt tgcaacttcc tgtggccagt gtgtataacc ccttccacta   3840

tctcacagat agtcacagcg tccattccat agtctgtctc ctcacatctg ttagtattga   3900

cacagcacag acaccacaag ccatcaggtt cttcatgggg caggtgaaat acttctaccc   3960

catgggtaaa tgtattcaca tattaccaag agaagaagca cattatctat gatcttttgg   4020

cccagttctt atttagcatt tttattccag cctacttgga aacatgtttt tatttgcaat   4080

atatgcctga ctgaattaag cttgcttgtt ttaaacaacc aaatcattgg aacagaaaag   4140

gatttaaaaa acaagaatgc atgatctcag agtgattaaa aaaaaatcag tggaaataaa   4200

tgatcataga aggtgctttt caaaacaact gctattataa ttctcaaagt cctactctgc   4260

caaaagaaga ttaaaagtca tacattacat tacaaggaaa tgttcatgtg ggaagagggt   4320

tgctgaaaat caacaacgct tgaagttaaa aagtgtgtct ttgtagattt cattgtataa   4380

tgtgtatttc ttaggagatg gctgacttga ttgatctacg ctaagtggag acatttcaca   4440

tttttaaaac caaatgttca atctgtatta ctctttgccg tcttgtatgt agaggctatt   4500

tttaaatcat taaattttta gatctctgtt ttcata                             4536


<210>  3103
<211>  834
<212>  PRT
<213>  Homo sapiens

<400>  3103

Met Lys Tyr Lys Asn Leu Met Ala Arg Ala Leu Tyr Asp Asn Val Pro 
1               5                   10                  15


Glu Cys Ala Glu Glu Leu Ala Phe Arg Lys Gly Asp Ile Leu Thr Val 
            20                  25                  30


Ile Glu Gln Asn Thr Gly Gly Leu Glu Gly Trp Trp Leu Cys Ser Leu 
        35                  40                  45


His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Val Lys Leu Leu Ile 
    50                  55                  60


Gly Pro Met Gln Glu Thr Ala Ser Ser His Glu Gln Pro Ala Ser Gly 
65                  70                  75                  80


Leu Met Gln Gln Thr Phe Gly Gln Gln Lys Leu Tyr Gln Val Pro Asn 
                85                  90                  95


Pro Gln Ala Ala Pro Arg Asp Thr Ile Tyr Gln Val Pro Pro Ser Tyr 
            100                 105                 110


Gln Asn Gln Gly Ile Tyr Gln Val Pro Thr Gly His Gly Thr Gln Glu 
        115                 120                 125


Gln Glu Val Tyr Gln Val Pro Pro Ser Val Gln Arg Ser Ile Gly Gly 
    130                 135                 140


Thr Ser Gly Pro His Val Gly Lys Lys Val Ile Thr Pro Val Arg Thr 
145                 150                 155                 160


Gly His Gly Tyr Val Tyr Glu Tyr Pro Ser Arg Tyr Gln Lys Asp Val 
                165                 170                 175


Tyr Asp Ile Pro Pro Ser His Thr Thr Gln Gly Val Tyr Asp Ile Pro 
            180                 185                 190


Pro Ser Ser Ala Lys Gly Pro Val Phe Ser Val Pro Val Gly Glu Ile 
        195                 200                 205


Lys Pro Gln Gly Val Tyr Asp Ile Pro Pro Thr Lys Gly Val Tyr Ala 
    210                 215                 220


Ile Pro Pro Ser Ala Cys Arg Asp Glu Ala Gly Leu Arg Glu Lys Asp 
225                 230                 235                 240


Tyr Asp Phe Pro Pro Pro Met Arg Gln Ala Gly Arg Pro Asp Leu Arg 
                245                 250                 255


Pro Glu Gly Val Tyr Asp Ile Pro Pro Thr Cys Thr Lys Pro Ala Gly 
            260                 265                 270


Lys Asp Leu His Val Lys Tyr Asn Cys Asp Ile Pro Gly Ala Ala Glu 
        275                 280                 285


Pro Val Ala Arg Arg His Gln Ser Leu Ser Pro Asn His Pro Pro Pro 
    290                 295                 300


Gln Leu Gly Gln Ser Val Gly Ser Gln Asn Asp Ala Tyr Asp Val Pro 
305                 310                 315                 320


Arg Gly Val Gln Phe Leu Glu Pro Pro Ala Glu Thr Ser Glu Lys Ala 
                325                 330                 335


Asn Pro Gln Glu Arg Asp Gly Val Tyr Asp Val Pro Leu His Asn Pro 
            340                 345                 350


Pro Asp Ala Lys Gly Ser Arg Asp Leu Val Asp Gly Ile Asn Arg Leu 
        355                 360                 365


Ser Phe Ser Ser Thr Gly Ser Thr Arg Ser Asn Met Ser Thr Ser Ser 
    370                 375                 380


Thr Ser Ser Lys Glu Ser Ser Leu Ser Ala Ser Pro Ala Gln Asp Lys 
385                 390                 395                 400


Arg Leu Phe Leu Asp Pro Asp Thr Ala Ile Glu Arg Leu Gln Arg Leu 
                405                 410                 415


Gln Gln Ala Leu Glu Met Gly Val Ser Ser Leu Met Ala Leu Val Thr 
            420                 425                 430


Thr Asp Trp Arg Cys Tyr Gly Tyr Met Glu Arg His Ile Asn Glu Ile 
        435                 440                 445


Arg Thr Ala Val Asp Lys Val Glu Leu Phe Leu Lys Glu Tyr Leu His 
    450                 455                 460


Phe Val Lys Gly Ala Val Ala Asn Ala Ala Cys Leu Pro Glu Leu Ile 
465                 470                 475                 480


Leu His Asn Lys Met Lys Arg Glu Leu Gln Arg Val Glu Asp Ser His 
                485                 490                 495


Gln Ile Leu Ser Gln Thr Ser His Asp Leu Asn Glu Cys Ser Trp Ser 
            500                 505                 510


Leu Asn Ile Leu Ala Ile Asn Lys Pro Gln Asn Lys Cys Asp Asp Leu 
        515                 520                 525


Asp Arg Phe Val Met Val Ala Lys Thr Val Pro Asp Asp Ala Lys Gln 
    530                 535                 540


Leu Thr Thr Thr Ile Asn Thr Asn Ala Glu Ala Leu Phe Arg Pro Gly 
545                 550                 555                 560


Pro Gly Ser Leu His Leu Lys Asn Gly Pro Glu Ser Ile Met Asn Ser 
                565                 570                 575


Thr Glu Tyr Pro His Gly Gly Ser Gln Gly Gln Leu Leu His Pro Gly 
            580                 585                 590


Asp His Lys Ala Gln Ala His Asn Lys Ala Leu Pro Pro Gly Leu Ser 
        595                 600                 605


Lys Glu Gln Ala Pro Asp Cys Ser Ser Ser Asp Gly Ser Glu Arg Ser 
    610                 615                 620


Trp Met Asp Asp Tyr Asp Tyr Val His Leu Gln Gly Lys Glu Glu Phe 
625                 630                 635                 640


Glu Arg Gln Gln Lys Glu Leu Leu Glu Lys Glu Asn Ile Met Lys Gln 
                645                 650                 655


Asn Lys Met Gln Leu Glu His His Gln Leu Ser Gln Phe Gln Leu Leu 
            660                 665                 670


Glu Gln Glu Ile Thr Lys Pro Val Glu Asn Asp Ile Ser Lys Trp Lys 
        675                 680                 685


Pro Ser Gln Ser Leu Pro Thr Thr Asn Ser Gly Val Ser Ala Gln Asp 
    690                 695                 700


Arg Gln Leu Leu Cys Phe Tyr Tyr Asp Gln Cys Glu Thr His Phe Ile 
705                 710                 715                 720


Ser Leu Leu Asn Ala Ile Asp Ala Leu Phe Ser Cys Val Ser Ser Ala 
                725                 730                 735


Gln Pro Pro Arg Ile Phe Val Ala His Ser Lys Phe Val Ile Leu Ser 
            740                 745                 750


Ala His Lys Leu Val Phe Ile Gly Asp Thr Leu Thr Arg Gln Val Thr 
        755                 760                 765


Ala Gln Asp Ile Arg Asn Lys Val Met Asn Ser Ser Asn Gln Leu Cys 
    770                 775                 780


Glu Gln Leu Lys Thr Ile Val Met Ala Thr Lys Met Ala Ala Leu His 
785                 790                 795                 800


Tyr Pro Ser Thr Thr Ala Leu Gln Glu Met Val His Gln Val Thr Asp 
                805                 810                 815


Leu Ser Arg Asn Ala Gln Leu Phe Lys Arg Ser Leu Leu Glu Met Ala 
            820                 825                 830


Thr Phe 



<210>  3104
<211>  3016
<212>  DNA
<213>  Homo sapiens

<400>  3104
acaacagtga gctcagagac ttgagggagg cgctgcgact gacaagcggc tctgcccggg     60

accttctcgc tttcatctag cgctgcactc aatggagggg cgggcaccgc agtgcttaat    120

gctgtcttaa ctagtgtagg aaaacggctc aacccaccgc tgccgaaatg aagtataaga    180

atcttatggc aagggcctta tatgacaatg tcccagagtg tgccgaggaa ctggcctttc    240

gcaagggaga catcctgacc gtcatagagc agaacacagg gggactggaa ggatggtggc    300

tgtgctcatt acacggtcgg caaggcattg tcccaggcaa ccgggtgaag cttctgattg    360

gtcccatgca ggagactgcc tccagtcacg agcagcctgc ctctggactg atgcagcaga    420

cctttggcca acagaagctc tatcaagtgc caaacccaca ggctgctccc cgagacacca    480

tctaccaagt gccaccttcc taccaaaatc agggaattta ccaagtcccc actggccacg    540

gcacccaaga acaagaggta tatcaggtgc caccatcagt gcagagaagc attgggggaa    600

ccagtgggcc ccacgtgggt aaaaaggtga taacccccgt gaggacaggc catggctacg    660

tatacgagta cccatccaga taccaaaagg acgtctatga tatccctcct tctcatacca    720

ctcaaggggt atacgacatc cctccctcat cagcaaaagg ccctgtgttt tcagttccag    780

tgggagagat aaaacctcaa ggggtgtatg acatcccgcc tacaaaaggg gtatatgcca    840

ttccgccctc tgcttgccgg gatgaagcag ggcttaggga aaaagactat gacttccccc    900

ctcccatgag acaagctgga aggccggacc tcagaccgga gggggtttat gacattcctc    960

caacctgcac caagccagca gggaaggacc ttcatgtaaa atacaactgt gacattccag   1020

gagctgcaga accggtggct cgaaggcacc agagcctgtc cccgaatcac ccacccccgc   1080

aactcggaca gtcagtgggc tctcagaacg acgcatatga tgtcccccga ggcgttcagt   1140

ttcttgagcc accagcagaa accagtgaga aagcaaaccc ccaggaaagg gatggtgttt   1200

atgatgtccc tctgcataac ccgccagatg ctaaaggctc tcgggacttg gtggatggga   1260

tcaaccgatt gtctttctcc agtacaggca gcacccggag taacatgtcc acgtcttcca   1320

cctcctccaa ggagtcctca ctgtcagcct ccccagctca ggacaaaagg ctcttcctgg   1380

atccagacac agctattgag agacttcagc ggctccagca ggcccttgag atgggtgtct   1440

ccagcctaat ggcactggtc actaccgact ggcggtgtta cggatatatg gaaagacaca   1500

tcaatgaaat acgcacagca gtggacaagg tggagctgtt cctgaaggag tacctccact   1560

ttgtcaaggg agctgttgca aatgctgcct gcctcccgga actcatcctc cacaacaaga   1620

tgaagcggga gctgcaacga gttgaagact cccaccagat cctgagtcaa accagccatg   1680

acttaaatga gtgcagctgg tccctgaata tcttggccat caacaagccc cagaacaagt   1740

gtgacgatct ggaccggttt gtgatggtgg caaagacggt gcccgatgac gccaagcagc   1800

tcaccacaac catcaacacc aacgcagagg ccctcttcag acccggccct ggcagcttgc   1860

atctgaagaa tgggccggag agcatcatga actcaacgga gtacccacac ggtggctccc   1920

agggacagct gctgcatcct ggtgaccaca aggcccaggc ccacaacaag gcactgcccc   1980

caggcctgag caaggagcag gcccctgact gtagcagcag tgatggttct gagaggagct   2040

ggatggatga ctacgattac gtccacctac agggtaagga ggagtttgag aggcaacaga   2100

aagagctatt ggaaaaagag aatatcatga aacagaacaa gatgcagctg gaacatcatc   2160

agctgagcca gttccagctg ttggaacaag agattacaaa gcccgtggag aatgacatct   2220

cgaagtggaa gccctctcag agcctaccca ccacaaacag tggcgtgagt gctcaggatc   2280

ggcagttgct gtgcttctac tatgaccaat gtgagaccca tttcatttcc cttctcaacg   2340

ccattgacgc actcttcagt tgtgtcagct cagcccagcc cccgcgaatc ttcgtggcac   2400

acagcaagtt tgtcatcctc agtgcacaca aactggtgtt cattggagac acgctgacac   2460

ggcaggtgac tgcccaggac attcgcaaca aagtcatgaa ctccagcaac cagctctgcg   2520

agcagctcaa gaccatagtc atggcaacca agatggccgc cctccattac cccagcacca   2580

cggccctgca ggaaatggtg caccaagtga cagacctttc tagaaatgcc cagctgttca   2640

agcgctcttt gctggagatg gcaacgttct gagaagaaaa aaaagaggaa ggggactgcg   2700

ttaacggtta ctaaggaaaa ctggaaatac tgtctggttt ttgtaaatgt tatctatttt   2760

tgtagatatt ttatataaaa atgaaatatt ttaacatttt atgggtcagt caactttcag   2820

aaattcaggg agctggagag ggaaatcttt ttttttcccc ctgagtggtt cttatgtata   2880

catagaagta tctgagacat aaactgtaca gaaaacttgt ccacgtgctt ttgtatgccc   2940

atgtattcat gtttgtttgt agatgtttgt ctgatgcatt tcattaaaaa aaaaaccatg   3000

aattacgaag cacctt                                                   3016


<210>  3105
<211>  834
<212>  PRT
<213>  Homo sapiens

<400>  3105

Met Lys Tyr Lys Asn Leu Met Ala Arg Ala Leu Tyr Asp Asn Val Pro 
1               5                   10                  15


Glu Cys Ala Glu Glu Leu Ala Phe Arg Lys Gly Asp Ile Leu Thr Val 
            20                  25                  30


Ile Glu Gln Asn Thr Gly Gly Leu Glu Gly Trp Trp Leu Cys Ser Leu 
        35                  40                  45


His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Val Lys Leu Leu Ile 
    50                  55                  60


Gly Pro Met Gln Glu Thr Ala Ser Ser His Glu Gln Pro Ala Ser Gly 
65                  70                  75                  80


Leu Met Gln Gln Thr Phe Gly Gln Gln Lys Leu Tyr Gln Val Pro Asn 
                85                  90                  95


Pro Gln Ala Ala Pro Arg Asp Thr Ile Tyr Gln Val Pro Pro Ser Tyr 
            100                 105                 110


Gln Asn Gln Gly Ile Tyr Gln Val Pro Thr Gly His Gly Thr Gln Glu 
        115                 120                 125


Gln Glu Val Tyr Gln Val Pro Pro Ser Val Gln Arg Ser Ile Gly Gly 
    130                 135                 140


Thr Ser Gly Pro His Val Gly Lys Lys Val Ile Thr Pro Val Arg Thr 
145                 150                 155                 160


Gly His Gly Tyr Val Tyr Glu Tyr Pro Ser Arg Tyr Gln Lys Asp Val 
                165                 170                 175


Tyr Asp Ile Pro Pro Ser His Thr Thr Gln Gly Val Tyr Asp Ile Pro 
            180                 185                 190


Pro Ser Ser Ala Lys Gly Pro Val Phe Ser Val Pro Val Gly Glu Ile 
        195                 200                 205


Lys Pro Gln Gly Val Tyr Asp Ile Pro Pro Thr Lys Gly Val Tyr Ala 
    210                 215                 220


Ile Pro Pro Ser Ala Cys Arg Asp Glu Ala Gly Leu Arg Glu Lys Asp 
225                 230                 235                 240


Tyr Asp Phe Pro Pro Pro Met Arg Gln Ala Gly Arg Pro Asp Leu Arg 
                245                 250                 255


Pro Glu Gly Val Tyr Asp Ile Pro Pro Thr Cys Thr Lys Pro Ala Gly 
            260                 265                 270


Lys Asp Leu His Val Lys Tyr Asn Cys Asp Ile Pro Gly Ala Ala Glu 
        275                 280                 285


Pro Val Ala Arg Arg His Gln Ser Leu Ser Pro Asn His Pro Pro Pro 
    290                 295                 300


Gln Leu Gly Gln Ser Val Gly Ser Gln Asn Asp Ala Tyr Asp Val Pro 
305                 310                 315                 320


Arg Gly Val Gln Phe Leu Glu Pro Pro Ala Glu Thr Ser Glu Lys Ala 
                325                 330                 335


Asn Pro Gln Glu Arg Asp Gly Val Tyr Asp Val Pro Leu His Asn Pro 
            340                 345                 350


Pro Asp Ala Lys Gly Ser Arg Asp Leu Val Asp Gly Ile Asn Arg Leu 
        355                 360                 365


Ser Phe Ser Ser Thr Gly Ser Thr Arg Ser Asn Met Ser Thr Ser Ser 
    370                 375                 380


Thr Ser Ser Lys Glu Ser Ser Leu Ser Ala Ser Pro Ala Gln Asp Lys 
385                 390                 395                 400


Arg Leu Phe Leu Asp Pro Asp Thr Ala Ile Glu Arg Leu Gln Arg Leu 
                405                 410                 415


Gln Gln Ala Leu Glu Met Gly Val Ser Ser Leu Met Ala Leu Val Thr 
            420                 425                 430


Thr Asp Trp Arg Cys Tyr Gly Tyr Met Glu Arg His Ile Asn Glu Ile 
        435                 440                 445


Arg Thr Ala Val Asp Lys Val Glu Leu Phe Leu Lys Glu Tyr Leu His 
    450                 455                 460


Phe Val Lys Gly Ala Val Ala Asn Ala Ala Cys Leu Pro Glu Leu Ile 
465                 470                 475                 480


Leu His Asn Lys Met Lys Arg Glu Leu Gln Arg Val Glu Asp Ser His 
                485                 490                 495


Gln Ile Leu Ser Gln Thr Ser His Asp Leu Asn Glu Cys Ser Trp Ser 
            500                 505                 510


Leu Asn Ile Leu Ala Ile Asn Lys Pro Gln Asn Lys Cys Asp Asp Leu 
        515                 520                 525


Asp Arg Phe Val Met Val Ala Lys Thr Val Pro Asp Asp Ala Lys Gln 
    530                 535                 540


Leu Thr Thr Thr Ile Asn Thr Asn Ala Glu Ala Leu Phe Arg Pro Gly 
545                 550                 555                 560


Pro Gly Ser Leu His Leu Lys Asn Gly Pro Glu Ser Ile Met Asn Ser 
                565                 570                 575


Thr Glu Tyr Pro His Gly Gly Ser Gln Gly Gln Leu Leu His Pro Gly 
            580                 585                 590


Asp His Lys Ala Gln Ala His Asn Lys Ala Leu Pro Pro Gly Leu Ser 
        595                 600                 605


Lys Glu Gln Ala Pro Asp Cys Ser Ser Ser Asp Gly Ser Glu Arg Ser 
    610                 615                 620


Trp Met Asp Asp Tyr Asp Tyr Val His Leu Gln Gly Lys Glu Glu Phe 
625                 630                 635                 640


Glu Arg Gln Gln Lys Glu Leu Leu Glu Lys Glu Asn Ile Met Lys Gln 
                645                 650                 655


Asn Lys Met Gln Leu Glu His His Gln Leu Ser Gln Phe Gln Leu Leu 
            660                 665                 670


Glu Gln Glu Ile Thr Lys Pro Val Glu Asn Asp Ile Ser Lys Trp Lys 
        675                 680                 685


Pro Ser Gln Ser Leu Pro Thr Thr Asn Ser Gly Val Ser Ala Gln Asp 
    690                 695                 700


Arg Gln Leu Leu Cys Phe Tyr Tyr Asp Gln Cys Glu Thr His Phe Ile 
705                 710                 715                 720


Ser Leu Leu Asn Ala Ile Asp Ala Leu Phe Ser Cys Val Ser Ser Ala 
                725                 730                 735


Gln Pro Pro Arg Ile Phe Val Ala His Ser Lys Phe Val Ile Leu Ser 
            740                 745                 750


Ala His Lys Leu Val Phe Ile Gly Asp Thr Leu Thr Arg Gln Val Thr 
        755                 760                 765


Ala Gln Asp Ile Arg Asn Lys Val Met Asn Ser Ser Asn Gln Leu Cys 
    770                 775                 780


Glu Gln Leu Lys Thr Ile Val Met Ala Thr Lys Met Ala Ala Leu His 
785                 790                 795                 800


Tyr Pro Ser Thr Thr Ala Leu Gln Glu Met Val His Gln Val Thr Asp 
                805                 810                 815


Leu Ser Arg Asn Ala Gln Leu Phe Lys Arg Ser Leu Leu Glu Met Ala 
            820                 825                 830


Thr Phe 



<210>  3106
<211>  3274
<212>  DNA
<213>  Homo sapiens

<400>  3106
tcctctccac agcctcgtga ggtgcacctc acagcatttg ctgttcagag gagggaactg     60

aggtctgaga aggaaattca cttgctgaag ttaacttgct gcctccagtg agaggcagga    120

ttgatatttg agcccacgtc tgtctgactc caatgctaat gatttttaca tcccggctga    180

aggatgatat tgccaagccc ttaaagaaga aggcatattt ggacacctca ttagcaattt    240

gggcgctaaa tcataccctg ttggccagga agaattaaag ttgctgccca gggctcccac    300

ctcaggtcca gggagtagcc tcaatactga gggaatctga attaaggagc ttggaagttc    360

cccccaccta gctgtagtgg gcagtttcag agtgggctga tccaggagtc ctgaccaggt    420

cagtagggtg atgtctagac tccagtacca ctgagaatgt tgctatgttg gctttctctg    480

ccacacagaa aagtcttttc tttccttttc ttttctttct ttctttcttt tttttttttt    540

tttttgagac ggaccctccc tctgttgacc aggctggagt gcagtggcac aatctcggct    600

caccacaacc tccgcctcct gggttcaagt gattctcctg ccttagcctc ccgagtagct    660

gggactatgg gtgcgcacta ccatgcctgg ctaatttttg tatttttagt agagacaaag    720

tttcactacg ttggcaaggc tggtctcaaa ctcctgacct cgtgatctgc ccacctcggc    780

ctcccaaagt gctgggatta taggcgtgag ccaccacgcc tggcctaaga ctgtctttcc    840

aaatgacttc aaattccttc aaatgggtaa cttcatttaa ccaggtgggg gcacctccca    900

aaacacaagt tacccagctt tcaagttgtg gctctcatat aaggaagtaa ctttctttga    960

gagtatttac ttgtgaaatt ataaaagtag taaatttctg gaaaatgtct aacatgtatt   1020

gctagcgtag gccgcagggc attgagaaac gtataccgct gcactgctgg cccagctaac   1080

caagggtctc cttcacttct ttgtcattaa tagcctgagt aactaactcc actttagttc   1140

cctcaactgt gaaatggcaa gtgatgctag attatctcta atgatctttg ctaaaatttt   1200

atgatccaga tatccttatc tgattctttc tcagaatcac tttaacagtt taataaaaac   1260

ggcctgacat caagagtttt ttttttttta aagaaaagat actcaagcat tgattataaa   1320

tttcaacttg acccttaagt ttttgcaaat ctttcctact cttcctttag gatccagccc   1380

accatcccat ccagaactct acccaactct tcctttcaaa gagtaggatt tttctgcttc   1440

gtttttttac tgctttgttc ttacttaggg ttgctggaag cacatggaag gagggaagta   1500

gtcaaaacaa gacagtgttg tgaggggaga gatgagaagt catgataagt aggtgggtgg   1560

gtgacccaca gggctggcat cagaaggaaa catagcaaaa catgatggat atgaggcttg   1620

ctgtggggag ggggattggc ctttgtgagt ggcagccgtc tgctcccttc ccgcttccct   1680

tagtgctcca ttgagctagc agcatgcagc tgagaagttg aagttctgac cacatggcct   1740

ctgctgccgc tgctctgccc catcccaggc acctagccag ctctgcatta aggaggtgaa   1800

gtggatgccc aaggaaagaa gtgcccccaa ggagacttgc tgagaccttg aacaagtgac   1860

acaatgtgag cagaacttgt cttgacagaa aatgctttgt ctctaggtgt tccagagaga   1920

tgggcaagtg tcctatttct tagtgagagc ctctaaacaa accagcttgt gaacctccac   1980

tgaaaagatc tcatctgatg agcattttaa taaagtgtcc tgagtttgga ggcttgccgt   2040

ctttctcttg gataaatatc ttcatctcct agacttggaa aaacacattt tctcctgggg   2100

tttcccattg gcgtgtcttg agctgctctg gtgataaccg taataatgcc aatactgata   2160

cgaacagcag aaaacagtaa ccccaagaac tctacagatg atcatcaagg accactgtct   2220

cttaccattt gctgctttgg tttgaaattc tcactgcctc gtagatctca ttttgagcac   2280

tatacattcc taaagattga tttctttcta tctgacttaa atttaggaat gattaaatct   2340

tcatttctcc catgatttga tcctaaaaca ttttgaaagg aaacagcctt gagatctgtg   2400

attactaaga catacataac attcttatca cattagaaag caagaattga ctgttgcttg   2460

tcttgttcct gttgtcttgt cccctgaatt cctgtttatc tttgattgta tgtgggacat   2520

tgtattttca gtacatttgt agaaataatg tgaagcctat aaagatgttc tctgcctcca   2580

gagagaattt tgtttccttc tgccagcctc ataggcaagc atacatctga ttccatgctt   2640

tgagctgttc tggcaaccct gatgtcttca gcctgtgcaa gggtgggttt acttccagtt   2700

aatccttatt ttggatacag tccttagggt tccaacccaa agtcgggggt ggtttggggt   2760

ccctgccttg gtgagcccta tagtccaatg ttccccctta cccaaagaag ctgtagaaaa   2820

cccagcacag cctcccaggc accagtttca gatcagcaaa aaatagcaaa tgcccccagg   2880

cttgaaaagc aatctcacct ctattaactc ttctcccaaa gtttgaccta gtaattcttt   2940

attatccttg aactcttgac actattaaga agatcttttc ggctgggcgc agtggctcac   3000

gcctgtaatc ccagcacttt cggaggccga ggcgggcgga tcacgaggtc aggagatcga   3060

gatcgtcctg gctaacacgg taaaaccccg tctctactaa aaatacaaaa aattagctgg   3120

gcacggtggc gggcgcagtg ggcgggtgcc tgtagtccca gctactcgga aggctgaggc   3180

aggagaatgg cgtgaactca ggaggcggag cttgcggtga gccgagatct caccactgca   3240

ctccagcctg ggcgacagag taagactctg tctc                               3274


<210>  3107
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  3107

Met Leu Leu Cys Trp Leu Ser Leu Pro His Arg Lys Val Phe Ser Phe 
1               5                   10                  15


Leu Phe Phe Ser Phe Phe Leu Ser Phe Phe Phe Phe Phe Leu Arg Arg 
            20                  25                  30


Thr Leu Pro Leu Leu Thr Arg Leu Glu Cys Ser Gly Thr Ile Ser Ala 
        35                  40                  45


His His Asn Leu Arg Leu Leu Gly Ser Ser Asp Ser Pro Ala Leu Ala 
    50                  55                  60


Ser Arg Val Ala Gly Thr Met Gly Ala His Tyr His Ala Trp Leu Ile 
65                  70                  75                  80


Phe Val Phe Leu Val Glu Thr Lys Phe His Tyr Val Gly Lys Ala Gly 
                85                  90                  95


Leu Lys Leu Leu Thr Ser 
            100


<210>  3108
<211>  1994
<212>  DNA
<213>  Homo sapiens

<400>  3108
acaacagtga gctcagagac ttgagggagg cgctgcgact gacaagcggc tctgcccggg     60

accttctcgc tttcatctag cgctgcactc aatggagggg cgggcaccgc agtgcttaat    120

gctgtcttaa ctagtgtagg aaaacggctc aacccaccgc tgccgaaatg aagtataaga    180

atcttatggc aagggcctta tatgacaatg tcccagagtg tgccgaggaa ctggcctttc    240

gcaagggaga catcctgacc gtcatagagc agaacacagg gggactggaa ggatggtggc    300

tgtgctcatt acacggtcgg caaggcattg tcccaggcaa ccgggtgaag cttctgattg    360

gtcccatgca ggagactgcc tccagtcacg agcagcctgc ctctggactg atgcagcaga    420

cctttggcca acagaagctc tatcaagtgc caaacccaca ggctgctccc cgagacacca    480

tctaccaagt gccaccttcc taccaaaatc agggaattta ccaagtcccc actggccacg    540

gcacccaaga acaagaggta tatcaggtgc caccatcagt gcagagaagc attgggggaa    600

ccagtgggcc ccacgtgggt aaaaaggtgt tccagagaga tgggcaagtg tcctatttct    660

tagtgagagc ctctaaacaa accagcttgt gaacctccac tgaaaagatc tcatctgatg    720

agcattttaa taaagtgtcc tgagtttgga ggcttgccgt ctttctcttg gataaatatc    780

ttcatctcct agacttggaa aaacacattt tctcctgggg tttcccattg gcgtgtcttg    840

agctgctctg gtgataaccg taataatgcc aatactgata cgaacagcag aaaacagtaa    900

ccccaagaac tctacagatg atcatcaagg accactgtct cttaccattt gctgctttgg    960

tttgaaattc tcactgcctc gtagatctca ttttgagcac tatacattcc taaagattga   1020

tttctttcta tctgacttaa atttaggaat gattaaatct tcatttctcc catgatttga   1080

tcctaaaaca ttttgaaagg aaacagcctt gagatctgtg attactaaga catacataac   1140

attcttatca cattagaaag caagaattga ctgttgcttg tcttgttcct gttgtcttgt   1200

cccctgaatt cctgtttatc tttgattgta tgtgggacat tgtattttca gtacatttgt   1260

agaaataatg tgaagcctat aaagatgttc tctgcctcca gagagaattt tgtttccttc   1320

tgccagcctc ataggcaagc atacatctga ttccatgctt tgagctgttc tggcaaccct   1380

gatgtcttca gcctgtgcaa gggtgggttt acttccagtt aatccttatt ttggatacag   1440

tccttagggt tccaacccaa agtcgggggt ggtttggggt ccctgccttg gtgagcccta   1500

tagtccaatg ttccccctta cccaaagaag ctgtagaaaa cccagcacag cctcccaggc   1560

accagtttca gatcagcaaa aaatagcaaa tgcccccagg cttgaaaagc aatctcacct   1620

ctattaactc ttctcccaaa gtttgaccta gtaattcttt attatccttg aactcttgac   1680

actattaaga agatcttttc ggctgggcgc agtggctcac gcctgtaatc ccagcacttt   1740

cggaggccga ggcgggcgga tcacgaggtc aggagatcga gatcgtcctg gctaacacgg   1800

taaaaccccg tctctactaa aaatacaaaa aattagctgg gcacggtggc gggcgcagtg   1860

ggcgggtgcc tgtagtccca gctactcgga aggctgaggc aggagaatgg cgtgaactca   1920

ggaggcggag cttgcggtga gccgagatct caccactgca ctccagcctg ggcgacagag   1980

taagactctg tctc                                                     1994


<210>  3109
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  3109

Met Lys Tyr Lys Asn Leu Met Ala Arg Ala Leu Tyr Asp Asn Val Pro 
1               5                   10                  15


Glu Cys Ala Glu Glu Leu Ala Phe Arg Lys Gly Asp Ile Leu Thr Val 
            20                  25                  30


Ile Glu Gln Asn Thr Gly Gly Leu Glu Gly Trp Trp Leu Cys Ser Leu 
        35                  40                  45


His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Val Lys Leu Leu Ile 
    50                  55                  60


Gly Pro Met Gln Glu Thr Ala Ser Ser His Glu Gln Pro Ala Ser Gly 
65                  70                  75                  80


Leu Met Gln Gln Thr Phe Gly Gln Gln Lys Leu Tyr Gln Val Pro Asn 
                85                  90                  95


Pro Gln Ala Ala Pro Arg Asp Thr Ile Tyr Gln Val Pro Pro Ser Tyr 
            100                 105                 110


Gln Asn Gln Gly Ile Tyr Gln Val Pro Thr Gly His Gly Thr Gln Glu 
        115                 120                 125


Gln Glu Val Tyr Gln Val Pro Pro Ser Val Gln Arg Ser Ile Gly Gly 
    130                 135                 140


Thr Ser Gly Pro His Val Gly Lys Lys Val Phe Gln Arg Asp Gly Gln 
145                 150                 155                 160


Val Ser Tyr Phe Leu Val Arg Ala Ser Lys Gln Thr Ser Leu 
                165                 170


<210>  3110
<211>  1299
<212>  DNA
<213>  Homo sapiens

<400>  3110
acaacagtga gctcagagac ttgagggagg cgctgcgact gacaagcggc tctgcccggg     60

accttctcgc tttcatctag cgctgcactc aatggagggg cgggcaccgc agtgcttaat    120

gctgtcttaa ctagtgtagg aaaacggctc aacccaccgc tgccgaaatg aagtataaga    180

atcttatggc aagggcctta tatgacaatg tcccagagtg tgccgaggaa ctggcctttc    240

gcaagggaga catcctgacc gtcatagagc agaacacagg gggactggaa ggatggtggc    300

tgtgctcatt acacggtcgg caaggcattg tcccaggcaa ccgggtgaag cttctgattg    360

gtcccatgca ggagactgcc tccagtcacg agcagcctgc ctctggactg atgcagcaga    420

cctttggcca acagaagctc tatcaagtgc caaacccaca ggctgctccc cgagacacca    480

tctaccaagt gccaccttcc taccaaaatc agggaattta ccaagtcccc actggccacg    540

gcacccaaga acaagaggta tatcaggtgc caccatcagt gcagagaagc attgggggaa    600

ccagtgggcc ccacgtgggt aaaaaggtgt tccagagaga tgggcaagtg tcctatttct    660

tagtgagagc ctctaaacaa accagcttgt gaacctccac tgaaaagatc tcatctgatg    720

agcattttaa taaagtgtcc tgagtttgga ggcttgccgt ctttctcttg gataaatatc    780

ttcatctcct agacttggaa aaacacattt tctcctgggg tttcccattg gcgtgtcttg    840

agctgctctg gtgataaccg taataatgcc aatactgata cgaacagcag aaaacagtaa    900

ccccaagaac tctacagatg atcatcaagg accactgtct cttaccattt gctgctttgg    960

tttgaaattc tcactgcctc gtagatctca ttttgagcac tatacattcc taaagattga   1020

tttctttcta tctgacttaa atttaggaat gattaaatct tcatttctcc catgatttga   1080

tcctaaaaca ttttgaaagg aaacagcctt gagatctgtg attactaaga catacataac   1140

attcttatca cattagaaag caagaattga ctgttgcttg tcttgttcct gttgtcttgt   1200

cccctgaatt cctgtttatc tttgattgta tgtgggacat tgtattttca gtacatttgt   1260

agaaataatg tgaagcctat aaagatgttc tctgcctcc                          1299


<210>  3111
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  3111

Met Lys Tyr Lys Asn Leu Met Ala Arg Ala Leu Tyr Asp Asn Val Pro 
1               5                   10                  15


Glu Cys Ala Glu Glu Leu Ala Phe Arg Lys Gly Asp Ile Leu Thr Val 
            20                  25                  30


Ile Glu Gln Asn Thr Gly Gly Leu Glu Gly Trp Trp Leu Cys Ser Leu 
        35                  40                  45


His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Val Lys Leu Leu Ile 
    50                  55                  60


Gly Pro Met Gln Glu Thr Ala Ser Ser His Glu Gln Pro Ala Ser Gly 
65                  70                  75                  80


Leu Met Gln Gln Thr Phe Gly Gln Gln Lys Leu Tyr Gln Val Pro Asn 
                85                  90                  95


Pro Gln Ala Ala Pro Arg Asp Thr Ile Tyr Gln Val Pro Pro Ser Tyr 
            100                 105                 110


Gln Asn Gln Gly Ile Tyr Gln Val Pro Thr Gly His Gly Thr Gln Glu 
        115                 120                 125


Gln Glu Val Tyr Gln Val Pro Pro Ser Val Gln Arg Ser Ile Gly Gly 
    130                 135                 140


Thr Ser Gly Pro His Val Gly Lys Lys Val Phe Gln Arg Asp Gly Gln 
145                 150                 155                 160


Val Ser Tyr Phe Leu Val Arg Ala Ser Lys Gln Thr Ser Leu 
                165                 170


<210>  3112
<211>  749
<212>  DNA
<213>  Homo sapiens

<400>  3112
acaacagtga gctcagagac ttgagggagg cgctgcgact gacaagcggc tctgcccggg     60

accttctcgc tttcatctag cgctgcactc aatggagggg cgggcaccgc agtgcttaat    120

gctgtcttaa ctagtgtagg aaaacggctc aacccaccgc tgccgaaatg aagtataaga    180

atcttatggc aagggcctta tatgacaatg tcccagagtg tgccgaggaa ctggcctttc    240

gcaagggaga catcctgacc gtcatagagc agaacacagg gggactggaa ggatggtggc    300

tgtgctcatt acacggtcgg caaggcattg tcccaggcaa ccgggtgaag cttctgattg    360

gtcccatgca ggagactgcc tccagtcacg agcagcctgc ctctggactg atgcagcaga    420

cctttggcca acagaagctc tatcaagtgc caaacccaca ggctgctccc cgagacacca    480

tctaccaagt gccaccttcc taccaaaatc agggaattta ccaagtcccc actggccacg    540

gcacccaaga acaagaggta tatcaggtgc caccatcagt gcagagaagc attgggggaa    600

ccagtgggcc ccacgtgggt aaaaaggtgt tccagagaga tgggcaagtg tcctatttct    660

tagtgagagc ctctaaacaa accagcttgt gaacctccac tgaaaagatc tcatctgatg    720

agcattttaa taaagtgtcc tgagtttgg                                      749


<210>  3113
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  3113

Met Lys Tyr Lys Asn Leu Met Ala Arg Ala Leu Tyr Asp Asn Val Pro 
1               5                   10                  15


Glu Cys Ala Glu Glu Leu Ala Phe Arg Lys Gly Asp Ile Leu Thr Val 
            20                  25                  30


Ile Glu Gln Asn Thr Gly Gly Leu Glu Gly Trp Trp Leu Cys Ser Leu 
        35                  40                  45


His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Val Lys Leu Leu Ile 
    50                  55                  60


Gly Pro Met Gln Glu Thr Ala Ser Ser His Glu Gln Pro Ala Ser Gly 
65                  70                  75                  80


Leu Met Gln Gln Thr Phe Gly Gln Gln Lys Leu Tyr Gln Val Pro Asn 
                85                  90                  95


Pro Gln Ala Ala Pro Arg Asp Thr Ile Tyr Gln Val Pro Pro Ser Tyr 
            100                 105                 110


Gln Asn Gln Gly Ile Tyr Gln Val Pro Thr Gly His Gly Thr Gln Glu 
        115                 120                 125


Gln Glu Val Tyr Gln Val Pro Pro Ser Val Gln Arg Ser Ile Gly Gly 
    130                 135                 140


Thr Ser Gly Pro His Val Gly Lys Lys Val Phe Gln Arg Asp Gly Gln 
145                 150                 155                 160


Val Ser Tyr Phe Leu Val Arg Ala Ser Lys Gln Thr Ser Leu 
                165                 170


<210>  3114
<211>  532
<212>  DNA
<213>  Homo sapiens

<400>  3114
ccgccgccgc ccggcacccg aggagagggc ggcgggcgcc cctcggggaa gatgaaggcg     60

gaggggggcg accactccat gatcaacctg tcggtgcagc aggtcctgag cctctgggcc    120

cacgggacgg tgctgaggaa cctcacggag atgtggtact ggatcttcct ctgggctctc    180

ttctcttctc tgtttgtcca tggtgctgca ggagtgttga tgtttgtgat gctgcagagg    240

cataggcagg gaagagtcat ctctgtcatt gcagtcagca ttggatttct ggcttctgta    300

actggagcga tgattaccag tgcagcagta gcgggcattt acagagtagc tgggaagaac    360

atggcccctt tggaagcgct ggtatggggc gttggacaga ctgtactgac attaatcatc    420

tccttttcaa ggatcctcgc tacactttga ggtttctgtg ggaatgtctt acttcacata    480

aggaaacaga tgtacagatt ccctgaaaac ggcattgtta acaagtggaa at            532


<210>  3115
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  3115

Met Lys Ala Glu Gly Gly Asp His Ser Met Ile Asn Leu Ser Val Gln 
1               5                   10                  15


Gln Val Leu Ser Leu Trp Ala His Gly Thr Val Leu Arg Asn Leu Thr 
            20                  25                  30


Glu Met Trp Tyr Trp Ile Phe Leu Trp Ala Leu Phe Ser Ser Leu Phe 
        35                  40                  45


Val His Gly Ala Ala Gly Val Leu Met Phe Val Met Leu Gln Arg His 
    50                  55                  60


Arg Gln Gly Arg Val Ile Ser Val Ile Ala Val Ser Ile Gly Phe Leu 
65                  70                  75                  80


Ala Ser Val Thr Gly Ala Met Ile Thr Ser Ala Ala Val Ala Gly Ile 
                85                  90                  95


Tyr Arg Val Ala Gly Lys Asn Met Ala Pro Leu Glu Ala Leu Val Trp 
            100                 105                 110


Gly Val Gly Gln Thr Val Leu Thr Leu Ile Ile Ser Phe Ser Arg Ile 
        115                 120                 125


Leu Ala Thr Leu 
    130


<210>  3116
<211>  1753
<212>  DNA
<213>  Homo sapiens

<400>  3116
cacttttttt agagccttgt ttaaaggaac gttaactcga gagtactact gatgatgacg     60

cttctcttgt ttttaaagta tttacacatc attgttaagt atttttggaa tggaacattt    120

taaagttttc tccatagaaa gcaacatagt ggcacttgtt gagtaaatga tcataaaaat    180

gacttgcttt taatagcaga tgagttgata gtttaactgt tgacactttc ttaatgtttt    240

tgatgttgga tgcatttaca atggaagaat ttttttgaaa gatttggccc tctcaccaat    300

acacacattc agacttgagc tgcacgcatt tagatgaaca aataggaaat tcacggtatt    360

ttttgtttta gccatccaaa attcatagga ttctaccaaa aatattagcc cctgactcta    420

gttattctga gatgagggaa tcaactttat cttgaaagtt aactagctaa aatgtcttta    480

tttaaatagc aaaaatatag tttacctgac aagtattaaa agtctcactt tcaaattgtg    540

ttaactctca gaccactgat gaatcttttg gtaaatcaca ggcagatttt aaaagctaaa    600

tgaagcctta gtgccttgaa agttaagata cttgtgcaaa atggatttag caagattcag    660

gattggcacc agtgagttgg ctagatacac atcaccagtg actgggaatt caaagtttag    720

aaagcctaac gaatagtagc tactaacttc atatggttca atgtaaatca gttacttagt    780

cattgactgt gacagatgac agctactttc actatatttt catgatgtgg tatttttctc    840

tattttttct ttttccaagt atgaaatgga aaaaaatgta gttaagaaaa ttaagtgtga    900

gactttaaaa tttagttttg ttgtaaacta gagattctag tgaacagtgt tagttttata    960

ctgtagtaca gggcacacac tttaaccttt agaaatatgt ttaccatcag ggatttattt   1020

ttactataga aatactaaat gtactgtgaa gcttaaagac aggagaataa atgttggagg   1080

ggtaatacac aaaaacaaag gcatatttga tgaagtaccc tgtgttatgt gaacacaatt   1140

tccccttctg ttaagactat aaactatatg agtatgtgta ctgcatgttt acataaaaca   1200

gtttaatttt gaaggattat tttaaaaact attttttatt tcccaattca tgtacaaatc   1260

tcattatgta tatagcataa tttcctggag aacacaaatt ttgcagtgaa ttttaagtaa   1320

ttttaattgc agtaagcatc agtttagcct agagatgttg atctttattt taaattattt   1380

ttcaccattc tcattttctt caaagggcag caataaacat atgcaagtta tttttaatta   1440

tagaaagtag gtctacaaag ataagatcta ggttccaatt cattgcttta aggaaaagat   1500

gcacaattac tatcattcag tgtctaatca caggaccatt tctgaggtcc acatgtggct   1560

ctcctctttg taatatacag ggtgaactct ttactgatac acacaagaca actgttaaaa   1620

agtgaatcca gcacttaaat gtcattacac agaatttatt ggattaaaaa tttgtaatat   1680

acagtatttt aataaagttt ctgtattcaa tttcatgcac ttatatataa ataaacctgt   1740

ctttgaaagc ttt                                                      1753


<210>  3117
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  3117

Met Leu Ile Phe Ile Leu Asn Tyr Phe Ser Pro Phe Ser Phe Ser Ser 
1               5                   10                  15


Lys Gly Ser Asn Lys His Met Gln Val Ile Phe Asn Tyr Arg Lys 
            20                  25                  30


<210>  3118
<211>  850
<212>  DNA
<213>  Homo sapiens

<400>  3118
ttctggttgt aaaagcgcga gttttgtttt cccatagtgt ggcctacagc agccatgggg     60

acacacgtgc ccctgcactc agggtcttca atcaggactg aacttcagac accagatggc    120

acatgcctgt aatctcagca ctttgggaga ccgaggcagg cggatcactt gaggtcagga    180

ggtcgagacc agcttggcca acatggtgta ctccaacatg aaaacggagc atgcatgtga    240

gctgagtagt gacatgcaac atgcatgtcc attgatcctt gctgctcatt cacatacagt    300

gttcgcgatg ccccctggac acagaattcc agtggaccca ccacgtgtgg ggattcaggg    360

gagactcaaa gcaaatacaa ggttccatac agatagccag ccatgggagt cagaatttga    420

actcagatct ggtctggttc tgaagcctct cttctttcca gctgtgagac aaaggagcaa    480

atatgagaag caccttttgc tcacttctgc ttgccagcag aatttcacaa aagccctgga    540

ctgtgaagat gtttggaaag atgctttgaa gacaaaacct ttaacagggt tagtgtttat    600

gcctctgtaa tctacaaccg gatgcgctct tacacccaag ccttgatggg attctgctgc    660

gacggaaatt ctgagcaaat ttgatgtgat tgtgcaggta ctgaacctcc acttcctgtc    720

tgtaagcagt gggctgaaat cctgggctgg agcagtctca taggatctga caggctgttg    780

ccaggctgta ggccttggtc tgtagtcctc agtaagactt ctgaatacaa ctaactttaa    840

ttctttaaaa                                                           850


<210>  3119
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  3119

Met Val Tyr Ser Asn Met Lys Thr Glu His Ala Cys Glu Leu Ser Ser 
1               5                   10                  15


Asp Met Gln His Ala Cys Pro Leu Ile Leu Ala Ala His Ser His Thr 
            20                  25                  30


Val Phe Ala Met Pro Pro Gly His Arg Ile Pro Val Asp Pro Pro Arg 
        35                  40                  45


Val Gly Ile Gln Gly Arg Leu Lys Ala Asn Thr Arg Phe His Thr Asp 
    50                  55                  60


Ser Gln Pro Trp Glu Ser Glu Phe Glu Leu Arg Ser Gly Leu Val Leu 
65                  70                  75                  80


Lys Pro Leu Phe Phe Pro Ala Val Arg Gln Arg Ser Lys Tyr Glu Lys 
                85                  90                  95


His Leu Leu Leu Thr Ser Ala Cys Gln Gln Asn Phe Thr Lys Ala Leu 
            100                 105                 110


Asp Cys Glu Asp Val Trp Lys Asp Ala Leu Lys Thr Lys Pro Leu Thr 
        115                 120                 125


Gly Leu Val Phe Met Pro Leu 
    130                 135


<210>  3120
<211>  3642
<212>  DNA
<213>  Homo sapiens

<400>  3120
tgcatgtgag ctgagtagtg acatgcaaca tgcatgtcca ttgatccttg ctgctcattc     60

acatacagtg ttcgcgatgc cccctggaca cagaattcca gtggacccac cacgtgtggg    120

gattcagggg agactcaaag caaatacaag gttccataca gatagccagc catgggagtc    180

agaatttgaa ctcagatctg gtctggttct gaagcctctc ttctttccag ctgtgagaca    240

aaggagcaaa tatgagaagc accttttgct cacttctgct tgccagcaga atttcacaaa    300

agccctggac tgtgaagatg tttggaaaga tgctttgaag acaaaacctt taacagggtt    360

agtgtttatg cctctgtaat ctacaaccgg atgcgctctt acacccaagc cttgatggga    420

ttctgctgcg acggaaattc tgagcaaatt tgatgtgatt gtgcaggaag aagcaacagg    480

attgtaccca cctataacga gaaagcttaa cttactgaca tattctcatt gctgaagact    540

ctgtctgaat gaggatttca atctcaagtc taggatgtga tttcatctgg taaatgtctt    600

atggaaggct gaggagcagc ctaatgaggt actgctgagt tgggaggagg tgggaggagc    660

tgagagggct atctggactc acttccctca aaatgaaacc ttgatatttt caaagcttgt    720

gtccctggag ccctcacttg ggttaggggg agacccctga ttttatttat tcatgctagg    780

gatggtaata ccttgttctc taggtcctgg gctttctaaa gaagattatt tttagctcta    840

aagttaaatg acacattgtt tgggggagga ggggagatcc tttgatgggg tcctttaaaa    900

gagtgcccca cccccaacgc tgtcctcttg ccttggcagg acctcttggc aggacctgtc    960

tgagtacttt ggacaaagac agtaagcatc attgcttctg tttgcggcta gtttttcttt   1020

ctgtttccag gtgaagggga gaggcagaca cggaagaagc gcatctgtag ctaagaaaga   1080

aatacactga ccccatttcc agtggttgag cttctctcca agtaggtaga tgctggcgat   1140

gaagacgtag ctgagagaga agaaagctgc tagacccaag aggctgagtt tggcaaacac   1200

aggatacacc caggtacccg tctcaaagta gagccatagg atgctgcagg aaataagaag   1260

tcgtggtggt tatagcagga ggagaaaaac aagccatttt ctcatcagga ttaatgaggt   1320

actggtaccc aggcagggga agagaaccca tcagggacgt ttgtcaacag ctgtagtatt   1380

cccacaaacc taaagaagtg aggcttttct gggtaaatca acttgattca ataagacatg   1440

ctgtttgatg ggctgggctg ggctgtttta cctaatccac ttaaattcaa cattggtgaa   1500

aaaatataag agaacatagg gccaggcact gtggctcatg cctgtaatcc cagcactttg   1560

ggaggctgag gggggtggat cacctgaggt caggagttcg agagcagcct ggccaacatg   1620

atgaaacccc atctccacta aaaatacaaa aaattaactg ggcatggtgg ctcaggcctg   1680

taatcccagc tactagggag gcggaggaag aagaatcgct tgaacctggg aggcagaggt   1740

tgcagtgatc caagatcacg ccactgcact ctagcctggg caacaagagt gaaactttgt   1800

ctcaaaaaca aacaaacaaa caaacaaaca aacatagaac catcgttagc taaagaacta   1860

aagagagtat gtgggaacat gaatgatccc tttccctgag aggtatggcc tgctgagaca   1920

ttgaacctgc tattatggca ttgattttgc tggctctaag ccagagaagt ggggtttgct   1980

tttttggatc taagaatcag gtgcagcttt cccttagctc tccaagtctg cggggatgag   2040

ggagcagaga tagagcgtta ttgccctaac acaatatgcc taggatttaa ctgtcggccc   2100

tgattttcac tcatgcatat agccataaat agagtgttag gcagtaatgc atggatttgc   2160

agggaggctc agatcttgct tatgtgagga taggctgtaa gtcatttctg gaagccgaga   2220

gaaggaaaag aaatgctagg agaagagcca tgatgtctaa gtgaagccta aaaatgcagt   2280

ttgctggaaa ccaactgcac tggaaggtgc caaagtctga aataacttta aaaaattaaa   2340

tgtggggaag ctgatgcatc agctacagtt catcattggt taggagcaca gaatctggaa   2400

ctgggcttct gtgattcaaa ccccagctct gccacctagt agctatgtta cctccagcaa   2460

tttcatcaac ctttctgtcc ccatctcctc aatgtgtaaa gtgaagatcc aaacagcata   2520

caccttctaa ggctgttgta aagattacgg gagttaacac atgtaaaaga cacagaacag   2580

tgcttggcac attgtaatat ttgacaagag ttcaaaagct tccatctcca ctgagggatg   2640

gcacaatggg agtgctctca gaaagccttc tttgaagctg ctgatctctt gtagcaatta   2700

ggataggcca ggttatgctt caaaaacaat atttaaattt gaatatccca cgttgtcaaa   2760

ggaattcaga tggaagaatg aaattctgtg cttaaacttt cagaaaccca agggtgatct   2820

ctgtcatttc aaatacttga agtttgttaa atggtttgtg gaagagtcaa gggctatatt   2880

caggaccggg agtagggtga agcaagagag gccctagggt gtaaaactta agggatcatc   2940

tctgcaacaa aggacacaat aaacagtgtg aaaaggcaat ccatggaatg ggaaacaata   3000

tttctaatca tatctctaat aaggggttaa tatccaaaat atgtaaaata ttcctgtaac   3060

tcaacaataa caaaaaaccc aaataactca attaaaaatg gacaaaggac ttgaatagac   3120

cttttacaga gaagatacat aaaaggccaa caaatgcatg aaaggatgtt caacatcact   3180

aataactaga agaaatgcaa atcaaaatga cagtgagata ttgtcttaca ctcattagga   3240

tggatactat atttttttta aaaagacaag ataacaagtg ttagtaagga catagagaaa   3300

ttggaaccct tgttcattgt tggtaggaat ggaagatggt acatctgcct tggaaaacta   3360

tatggtggtt ctccccaaaa ttaaaataga attaccatct gatccagcaa ttccacttct   3420

gggtacacac ccaaaagaac tgaaaacatg gctaacatgg tgaaacccca tctctactaa   3480

atatacaaaa aattagccag gcgtggtggc aggtgcctgt agtcccagct acttgggagg   3540

ctgagggcag gagaatggca tgaacctggg aggcagagct tgcagtgatt ggagatcgcg   3600

ccactgcact ccagcctggg cgagagaatg agactctatc tc                      3642


<210>  3121
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  3121

Met Gln His Ala Cys Pro Leu Ile Leu Ala Ala His Ser His Thr Val 
1               5                   10                  15


Phe Ala Met Pro Pro Gly His Arg Ile Pro Val Asp Pro Pro Arg Val 
            20                  25                  30


Gly Ile Gln Gly Arg Leu Lys Ala Asn Thr Arg Phe His Thr Asp Ser 
        35                  40                  45


Gln Pro Trp Glu Ser Glu Phe Glu Leu Arg Ser Gly Leu Val Leu Lys 
    50                  55                  60


Pro Leu Phe Phe Pro Ala Val Arg Gln Arg Ser Lys Tyr Glu Lys His 
65                  70                  75                  80


Leu Leu Leu Thr Ser Ala Cys Gln Gln Asn Phe Thr Lys Ala Leu Asp 
                85                  90                  95


Cys Glu Asp Val Trp Lys Asp Ala Leu Lys Thr Lys Pro Leu Thr Gly 
            100                 105                 110


Leu Val Phe Met Pro Leu 
        115


<210>  3122
<211>  1696
<212>  DNA
<213>  Homo sapiens

<400>  3122
gacagcgtga gccgtgccag ccctgtctcg ccatcccagc cgaggagggc agcgcgatgg     60

ctcttccctg ccttgaaatc aaccccattg ccagccgctt tcgccggcag agcattttcc    120

gtggggtcca tccggctcca aggcggcctg cgctggccac gtggaaagaa acacgcccac    180

tgcctacagg ccacgccctt cctcccttcg cgcatgcgcc ccacccgtcc tgaggacctc    240

cgaacctgca gggggcgatg aaagtaggct tgcgctccgc ttgtagctgc ttccgggtca    300

gaggtcagac ggtctagcgc tgcgtgggcc atggtgcagc tccgaccgcg agcgtctcgc    360

gccccggcgt cggcggaggc gatggtggac gagggccagc tggcctcgga ggaggaggag    420

gcggagcacg ggctgttgct cgggcagccc agcagcggcg cggccgccga gcccctggag    480

gaagacgagg aaggggacga tgagtttgac gatgaggccc cggaggagct gactttcgcc    540

agcgcccagg cggaagcgag agaagaggag cggcgagtgc gggagaccgt gcgcagggat    600

aaaacgctcc tgaaggagaa gaggaagcga cgcgaggagc tgttcatcga acagaagaaa    660

agaaaactcc ttccagacac tattttggag aagttaacca cagcttcaca gactaacatc    720

aagaaatcgc caggaaaggt gaaagaagtt aatttgcaaa agaaaaatga agactgtgaa    780

aaaggaaatg actccaagaa agttaaagta caaaaagtac agtctgtcag ccagaataaa    840

agctacttgg ccgtaaggct aaaagaccaa gatctgagag attcaaggca acaagcagca    900

caagccttca tacataattc attatatggg ccaggaacca acaggactac tgtaaataag    960

ttcctgtctc ttgccaacaa gaggttacca gtgaaaagag ctgctgtcca gtttttgaat   1020

aatgcttggg gaatccaaaa aaaacaaaat gccaagaggt ttaaaagacg gtggatggtc   1080

agaaagatga aaactaagaa gtaaatcaat gctaaatgaa gaatctgtac ttttgttctt   1140

gccacagtct ctccttagct gttcactcat tgcttgcagc tctcgtccaa agtggatcat   1200

tctttctatg gcggcctgac ttcctccaca caactggcgt ctcaactgac ttgaatcaac   1260

ttctgtaaga aaaacagaca agtattttac taccttatgg aatggagtat aatgaggaca   1320

cgaacataca tttcttatac cattttgtac atttagtaac tattccctaa tatttcatct   1380

aaatatgcag attgttaaaa attcattttt aatatgaaac tgcagctaaa agatatactt   1440

tatttagctc tcaagagtct aggatccagt attcagcatg cagttgagag gggacaacct   1500

ttcagtgtta gagggtactt atgtcagaaa aaaattttag aaaaagtata attccctaaa   1560

actacattaa gcaacattta aaaaaaaaaa aaaaaaaagg aaaactgtta ataatgccac   1620

tcaggctgcc ttaactgacg tagtagagat gtaataaaat gctcctgaaa gctaagaaaa   1680

gctaaatgac tacaat                                                   1696


<210>  3123
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  3123

Met Val Gln Leu Arg Pro Arg Ala Ser Arg Ala Pro Ala Ser Ala Glu 
1               5                   10                  15


Ala Met Val Asp Glu Gly Gln Leu Ala Ser Glu Glu Glu Glu Ala Glu 
            20                  25                  30


His Gly Leu Leu Leu Gly Gln Pro Ser Ser Gly Ala Ala Ala Glu Pro 
        35                  40                  45


Leu Glu Glu Asp Glu Glu Gly Asp Asp Glu Phe Asp Asp Glu Ala Pro 
    50                  55                  60


Glu Glu Leu Thr Phe Ala Ser Ala Gln Ala Glu Ala Arg Glu Glu Glu 
65                  70                  75                  80


Arg Arg Val Arg Glu Thr Val Arg Arg Asp Lys Thr Leu Leu Lys Glu 
                85                  90                  95


Lys Arg Lys Arg Arg Glu Glu Leu Phe Ile Glu Gln Lys Lys Arg Lys 
            100                 105                 110


Leu Leu Pro Asp Thr Ile Leu Glu Lys Leu Thr Thr Ala Ser Gln Thr 
        115                 120                 125


Asn Ile Lys Lys Ser Pro Gly Lys Val Lys Glu Val Asn Leu Gln Lys 
    130                 135                 140


Lys Asn Glu Asp Cys Glu Lys Gly Asn Asp Ser Lys Lys Val Lys Val 
145                 150                 155                 160


Gln Lys Val Gln Ser Val Ser Gln Asn Lys Ser Tyr Leu Ala Val Arg 
                165                 170                 175


Leu Lys Asp Gln Asp Leu Arg Asp Ser Arg Gln Gln Ala Ala Gln Ala 
            180                 185                 190


Phe Ile His Asn Ser Leu Tyr Gly Pro Gly Thr Asn Arg Thr Thr Val 
        195                 200                 205


Asn Lys Phe Leu Ser Leu Ala Asn Lys Arg Leu Pro Val Lys Arg Ala 
    210                 215                 220


Ala Val Gln Phe Leu Asn Asn Ala Trp Gly Ile Gln Lys Lys Gln Asn 
225                 230                 235                 240


Ala Lys Arg Phe Lys Arg Arg Trp Met Val Arg Lys Met Lys Thr Lys 
                245                 250                 255


Lys 



<210>  3124
<211>  2323
<212>  DNA
<213>  Homo sapiens

<400>  3124
ttaaatgttg cttaatgtag ttttagggaa ttatactttt tctaaaattt ttttctgaca     60

taagtaccct ctaacactga aaggttgtcc cctctcaact gcatgctgaa tactggatcc    120

tagactcttg agagctaaat aaagtatatc ttttagctgc agtttcatat taaaaatgaa    180

tttttaacaa tctgcatatt tagatgaaat attagggaat agttactaaa tgtacaaaat    240

ggtataagaa atgtatgttc gtgtcctcat tatactccat tccataaggt agtaaaatac    300

ttgtctgttt ttcttacaga agttgattca agtcagttga gacgccagtt gtgtggagga    360

agtcaggccg ccatagaaag aatgatccac tttggacgag agctgcaagc aatgagtgaa    420

cagctaagga gagactgtgg caagaacact gcaaacaaaa aaatgttgaa ggatgcattc    480

agtctactag catattcaga tccctggaac agcccagttg gaaatcagct tgacccgatt    540

cagagagaac ctgtgtgctc agctcttaac agtgcaatat tagaaaccca caatctgcca    600

aagcaacctc cacttgccct agcaatggga caggccacac aatgtctagg actgatggct    660

cgatcaggaa ttggatcctg cgcatttgcc acagtggaag actacctaca ttagctatgc    720

atttcaagag ctcacactta tattgtggca tatagtcaac atggaagtag accagctctg    780

ctgatttgaa atttagattt tttaaattat gtactgggga caggtttttg tcgctttaca    840

ttgcttccta gtttacagca tgatgcaaat gattttctaa cttagtgtta ggagaaatta    900

ttttccatct ttaacctctt agttgtctaa gagttaaata ttactgaatt tcagacgttc    960

aaattgatca tcacaaatcc tttaaaacaa ttacctaaaa gaaaccaaaa atcctgcctt   1020

ctttgtgggg gaggggggag agaggggaag gaaatggaac aagttgtgtt tgtgttagca   1080

tgtgggtgat gtaaacttca aattgggaga tgttccgacc cccactccca tataagcatt   1140

caatcagtgt aacttgcaaa atgcataaac atccgacagt ttgaatttat agtgttgatg   1200

gaagaaatca tttttaatgt gtactgtaaa acttgaaata ctcaggagct gagtgaatat   1260

gtttgttgct acttacaatc ccgacctgtt agtcccagta gttttgtttt aacatggtct   1320

ttttcaactt tgtttcctgt ttaactacag atgacttctg ttgtagactc acaagtttaa   1380

ctgttgtatt ataacagtat tacatgtcaa cggtgtggtt atgaccttta tttatataaa   1440

aaccaaatat ttagtcaatt taccgtgtct taatttaatc tttgtacacc ttccattttt   1500

aagtgcttaa atgagtacta tattgcaata aaatgtagtg atataattaa ccagccatta   1560

aaaatttact tctacagata cagtgtcaat tgagtttata tattaggtac ttgcatactt   1620

tttatgatta ctatgaaaat tagagcaatt aaaattaatg gtttctacaa ttaatctgag   1680

ttctacaacc taaaattgcc ttcagtttac tggcatccct ggattagggt tagacctgat   1740

attgtggctg acacagaaag gcaacaggaa attaacttca ttattttcat attcataata   1800

tggcatatga gactcaccag gcaagcaaat ccccagactg gttaaaagta aaaatttaaa   1860

agctgttagc tatattttgt gcactgaatc tttaatagca aattgtctac aggctgcagt   1920

tagagacttt gctggaatat ccatttctcc ttttagtccg tgccattttt gccacccctc   1980

taacccgggg agagtagaag aggtgctgtt gctgatgtgg gtatggcttg aattcagtta   2040

aatatattaa aaagaaaaca attccttctt aaaccacttt ttcctctagg attgcaaggc   2100

acagttctac tccagaagaa tgaaatgtgg ttgagcactt cctcaaatag gtttatgatt   2160

tttataatga tcctttaaaa tgatctatga atgatttatt agataaattc tatacataca   2220

aagtacagat tcttcattta gcattgattt acttcttagt tttcatcttt ctgaccatcc   2280

accgtctttt aaacctcttg gcattttgtt ttttttggat tcc                     2323


<210>  3125
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  3125

Met Ile His Phe Gly Arg Glu Leu Gln Ala Met Ser Glu Gln Leu Arg 
1               5                   10                  15


Arg Asp Cys Gly Lys Asn Thr Ala Asn Lys Lys Met Leu Lys Asp Ala 
            20                  25                  30


Phe Ser Leu Leu Ala Tyr Ser Asp Pro Trp Asn Ser Pro Val Gly Asn 
        35                  40                  45


Gln Leu Asp Pro Ile Gln Arg Glu Pro Val Cys Ser Ala Leu Asn Ser 
    50                  55                  60


Ala Ile Leu Glu Thr His Asn Leu Pro Lys Gln Pro Pro Leu Ala Leu 
65                  70                  75                  80


Ala Met Gly Gln Ala Thr Gln Cys Leu Gly Leu Met Ala Arg Ser Gly 
                85                  90                  95


Ile Gly Ser Cys Ala Phe Ala Thr Val Glu Asp Tyr Leu His 
            100                 105                 110


<210>  3126
<211>  4131
<212>  DNA
<213>  Homo sapiens

<400>  3126
ggaaacagcc gcgagagcag cggccgcggc ggccgccagc gcgccttccc ctcccgcgct     60

cccgcgtcgc ccccgccctc ggcgcctcgt ccccgggccg cgcgcccgcg ctccggccaa    120

cgttctctcc cggcctcccg ggcccgccgc ctactcccgc gtctccgagc tcctcaaccg    180

ccgcggtctc cctgggcgcg cggcccgccg cctgcttccg gggcgggcgg actgggcgcc    240

tggtgccggc ggccgcagcg acagcgcccc cgggaagcag aggaggaagg agagaagagg    300

tggaggtggc cgcaggctga gtcgcggccg ggatgtccgg gcagccgccg ccgccgccgc    360

cgcagcagca gcaacagcag cagcagctgt cgccgccacc gccggcggcc ttggccccag    420

tctccggagt cgtcctgccg gcgcccccgg ccgtcagcgc cggctcttct ccggccggct    480

cgcccggcgg cggtgcgggc ggcgaaggct taggggccgc ggcggccgcc ctgctcctcc    540

accctccgcc gccgccgccc ccggccaccg cggccccgcc gcccccgccg ccgcccccgc    600

ctccccctgc ctcagcggct gcccccgcca gcgggccgcc cgctcccccg ggccttgcag    660

cgggccccgg cccggctgga ggagccccga ccccagctct ggtggcgggc agcagcgccg    720

cggccccctt ccctcacggg gactcggccc tgaacgagca ggagaaggag ttgcagcggc    780

ggctgaagcg tctctacccg gccgtggacg aacaagagac gccgctgcct cggtcctgga    840

gcccgaagga caagttcagc tacatcggcc tctctcagaa caacctgcgg gtgcactaca    900

aaggtcatgg caaaacccca aaagatgccg cgtcagttcg agccacgcat ccaataccag    960

cagcctgtgg gatttattat tttgaagtaa aaattgtcag taagggaaga gatggttaca   1020

tgggaattgg tctttctgct caaggtgtga acatgaatag actaccaggt tgggataagc   1080

attcatatgg ttaccatggg gatgatggac attcgttttg ttcttctgga actggacaac   1140

cttatggacc aactttcact actggtgatg tcattggctg ttgtgttaat cttatcaaca   1200

atacctgctt ttacaccaag aatggacata gtttaggtat tgctttcact gacctaccgc   1260

caaatttgta tcctactgtg gggcttcaaa caccaggaga agtggtcgat gccaattttg   1320

ggcaacatcc tttcgtgttt gatatagaag actatatgcg ggagtggaga accaaaatcc   1380

aggcacagat agatcgattt cctatcggag atcgagaagg agaatggcag accatgatac   1440

aaaaaatggt ttcatcttat ttagtccacc atgggtactg tgccacagca gaggcctttg   1500

ccagatctac agaccagacc gttctagaag aattagcttc cattaagaat agacaaagaa   1560

ttcagaaatt ggtattagca ggaagaatgg gagaagccat tgaaacaaca caacagttat   1620

acccaagttt acttgaaaga aatcctaatc tccttttcac attaaaagtg cgtcagttta   1680

tagaaatggt gaatggtaca gatagtgaag tacgatgttt gggaggccga agtccaaagt   1740

ctcaagacag ttatcctgtt agtcctcgac cttttagtag tccaagtatg agccccagcc   1800

atggaatgaa tatccacaat ttagcatcag gcaaaggaag caccgcacat ttttcaggtt   1860

ttgaaagttg tagtaatggt gtaatatcaa ataaagcaca tcaatcatat tgccatagta   1920

ataaacacca gtcatccaac ttgaatgtac cagaactaaa cagtataaat atgtcaagat   1980

cacagcaagt taataacttc accagtaatg atgtagacat ggaaacagat cactactcca   2040

atggagttgg agaaacttca tccaatggtt tcctaaatgg tagctctaaa catgaccacg   2100

aaatggaaga ttgtgacacc gaaatggaag ttgattcaag tcagttgaga cgccagttgt   2160

gtggaggaag tcaggccgcc atagaaagaa tgatccactt tggacgagag ctgcaagcaa   2220

tgagtgaaca gctaaggaga gactgtggca agaacactgc aaacaaaaaa atgttgaagg   2280

atgcattcag tctactagca tattcagatc cctggaacag cccagttgga aatcagcttg   2340

acccgattca gagagaacct gtgtgctcag ctcttaacag tgcaatatta gaaacccaca   2400

atctgccaaa gcaacctcca cttgccctag caatgggaca ggccacacaa tgtctaggac   2460

tgatggctcg atcaggaatt ggatcctgcg catttgccac agtggaagac tacctacatt   2520

agctatgcat ttcaagagct cacacttata ttgtggcata tagtcaacat ggaagtagac   2580

cagctctgct gatttgaaat ttagattttt taaattatgt actggggaca ggtttttgtc   2640

gctttacatt gcttcctagt ttacagcatg atgcaaatga ttttctaact tagtgttagg   2700

agaaattatt ttccatcttt aacctcttag ttgtctaaga gttaaatatt actgaatttc   2760

agacgttcaa attgatcatc acaaatcctt taaaacaatt acctaaaaga aaccaaaaat   2820

cctgccttct ttgtggggga ggggggagag aggggaagga aatggaacaa gttgtgtttg   2880

tgttagcatg tgggtgatgt aaacttcaaa ttgggagatg ttccgacccc cactcccata   2940

taagcattca atcagtgtaa cttgcaaaat gcataaacat ccgacagttt gaatttatag   3000

tgttgatgga agaaatcatt tttaatgtgt actgtaaaac ttgaaatact caggagctga   3060

gtgaatatgt ttgttgctac ttacaatccc gacctgttag tcccagtagt tttgttttaa   3120

catggtcttt ttcaactttg tttcctgttt aactacagat gacttctgtt gtagactcac   3180

aagtttaact gttgtattat aacagtatta catgtcaacg gtgtggttat gacctttatt   3240

tatataaaaa ccaaatattt agtcaattta ccgtgtctta atttaatctt tgtacacctt   3300

ccatttttaa gtgcttaaat gagtactata ttgcaataaa atgtagtgat ataattaacc   3360

agccattaaa aatttacttc tacagataca gtgtcaattg agtttatata ttaggtactt   3420

gcatactttt tatgattact atgaaaatta gagcaattaa aattaatggt ttctacaatt   3480

aatctgagtt ctacaaccta aaattgcctt cagtttactg gcatccctgg attagggtta   3540

gacctgatat tgtggctgac acagaaaggc aacaggaaat taacttcatt attttcatat   3600

tcataatatg gcatatgaga ctcaccaggc aagcaaatcc ccagactggt taaaagtaaa   3660

aatttaaaag ctgttagcta tattttgtgc actgaatctt taatagcaaa ttgtctacag   3720

gctgcagtta gagactttgc tggaatatcc atttctcctt ttagtccgtg ccatttttgc   3780

cacccctcta acccggggag agtagaagag gtgctgttgc tgatgtgggt atggcttgaa   3840

ttcagttaaa tatattaaaa agaaaacaat tccttcttaa accacttttt cctctaggat   3900

tgcaaggcac agttctactc cagaagaatg aaatgtggtt gagcacttcc tcaaataggt   3960

ttatgatttt tataatgatc ctttaaaatg atctatgaat gatttattag ataaattcta   4020

tacatacaaa gtacagattc ttcatttagc attgatttac ttcttagttt tcatctttct   4080

gaccatccac cgtcttttaa acctcttggc attttgtttt ttttggattc c            4131


<210>  3127
<211>  729
<212>  PRT
<213>  Homo sapiens

<400>  3127

Met Ser Gly Gln Pro Pro Pro Pro Pro Pro Gln Gln Gln Gln Gln Gln 
1               5                   10                  15


Gln Gln Leu Ser Pro Pro Pro Pro Ala Ala Leu Ala Pro Val Ser Gly 
            20                  25                  30


Val Val Leu Pro Ala Pro Pro Ala Val Ser Ala Gly Ser Ser Pro Ala 
        35                  40                  45


Gly Ser Pro Gly Gly Gly Ala Gly Gly Glu Gly Leu Gly Ala Ala Ala 
    50                  55                  60


Ala Ala Leu Leu Leu His Pro Pro Pro Pro Pro Pro Pro Ala Thr Ala 
65                  70                  75                  80


Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Ser Ala Ala 
                85                  90                  95


Ala Pro Ala Ser Gly Pro Pro Ala Pro Pro Gly Leu Ala Ala Gly Pro 
            100                 105                 110


Gly Pro Ala Gly Gly Ala Pro Thr Pro Ala Leu Val Ala Gly Ser Ser 
        115                 120                 125


Ala Ala Ala Pro Phe Pro His Gly Asp Ser Ala Leu Asn Glu Gln Glu 
    130                 135                 140


Lys Glu Leu Gln Arg Arg Leu Lys Arg Leu Tyr Pro Ala Val Asp Glu 
145                 150                 155                 160


Gln Glu Thr Pro Leu Pro Arg Ser Trp Ser Pro Lys Asp Lys Phe Ser 
                165                 170                 175


Tyr Ile Gly Leu Ser Gln Asn Asn Leu Arg Val His Tyr Lys Gly His 
            180                 185                 190


Gly Lys Thr Pro Lys Asp Ala Ala Ser Val Arg Ala Thr His Pro Ile 
        195                 200                 205


Pro Ala Ala Cys Gly Ile Tyr Tyr Phe Glu Val Lys Ile Val Ser Lys 
    210                 215                 220


Gly Arg Asp Gly Tyr Met Gly Ile Gly Leu Ser Ala Gln Gly Val Asn 
225                 230                 235                 240


Met Asn Arg Leu Pro Gly Trp Asp Lys His Ser Tyr Gly Tyr His Gly 
                245                 250                 255


Asp Asp Gly His Ser Phe Cys Ser Ser Gly Thr Gly Gln Pro Tyr Gly 
            260                 265                 270


Pro Thr Phe Thr Thr Gly Asp Val Ile Gly Cys Cys Val Asn Leu Ile 
        275                 280                 285


Asn Asn Thr Cys Phe Tyr Thr Lys Asn Gly His Ser Leu Gly Ile Ala 
    290                 295                 300


Phe Thr Asp Leu Pro Pro Asn Leu Tyr Pro Thr Val Gly Leu Gln Thr 
305                 310                 315                 320


Pro Gly Glu Val Val Asp Ala Asn Phe Gly Gln His Pro Phe Val Phe 
                325                 330                 335


Asp Ile Glu Asp Tyr Met Arg Glu Trp Arg Thr Lys Ile Gln Ala Gln 
            340                 345                 350


Ile Asp Arg Phe Pro Ile Gly Asp Arg Glu Gly Glu Trp Gln Thr Met 
        355                 360                 365


Ile Gln Lys Met Val Ser Ser Tyr Leu Val His His Gly Tyr Cys Ala 
    370                 375                 380


Thr Ala Glu Ala Phe Ala Arg Ser Thr Asp Gln Thr Val Leu Glu Glu 
385                 390                 395                 400


Leu Ala Ser Ile Lys Asn Arg Gln Arg Ile Gln Lys Leu Val Leu Ala 
                405                 410                 415


Gly Arg Met Gly Glu Ala Ile Glu Thr Thr Gln Gln Leu Tyr Pro Ser 
            420                 425                 430


Leu Leu Glu Arg Asn Pro Asn Leu Leu Phe Thr Leu Lys Val Arg Gln 
        435                 440                 445


Phe Ile Glu Met Val Asn Gly Thr Asp Ser Glu Val Arg Cys Leu Gly 
    450                 455                 460


Gly Arg Ser Pro Lys Ser Gln Asp Ser Tyr Pro Val Ser Pro Arg Pro 
465                 470                 475                 480


Phe Ser Ser Pro Ser Met Ser Pro Ser His Gly Met Asn Ile His Asn 
                485                 490                 495


Leu Ala Ser Gly Lys Gly Ser Thr Ala His Phe Ser Gly Phe Glu Ser 
            500                 505                 510


Cys Ser Asn Gly Val Ile Ser Asn Lys Ala His Gln Ser Tyr Cys His 
        515                 520                 525


Ser Asn Lys His Gln Ser Ser Asn Leu Asn Val Pro Glu Leu Asn Ser 
    530                 535                 540


Ile Asn Met Ser Arg Ser Gln Gln Val Asn Asn Phe Thr Ser Asn Asp 
545                 550                 555                 560


Val Asp Met Glu Thr Asp His Tyr Ser Asn Gly Val Gly Glu Thr Ser 
                565                 570                 575


Ser Asn Gly Phe Leu Asn Gly Ser Ser Lys His Asp His Glu Met Glu 
            580                 585                 590


Asp Cys Asp Thr Glu Met Glu Val Asp Ser Ser Gln Leu Arg Arg Gln 
        595                 600                 605


Leu Cys Gly Gly Ser Gln Ala Ala Ile Glu Arg Met Ile His Phe Gly 
    610                 615                 620


Arg Glu Leu Gln Ala Met Ser Glu Gln Leu Arg Arg Asp Cys Gly Lys 
625                 630                 635                 640


Asn Thr Ala Asn Lys Lys Met Leu Lys Asp Ala Phe Ser Leu Leu Ala 
                645                 650                 655


Tyr Ser Asp Pro Trp Asn Ser Pro Val Gly Asn Gln Leu Asp Pro Ile 
            660                 665                 670


Gln Arg Glu Pro Val Cys Ser Ala Leu Asn Ser Ala Ile Leu Glu Thr 
        675                 680                 685


His Asn Leu Pro Lys Gln Pro Pro Leu Ala Leu Ala Met Gly Gln Ala 
    690                 695                 700


Thr Gln Cys Leu Gly Leu Met Ala Arg Ser Gly Ile Gly Ser Cys Ala 
705                 710                 715                 720


Phe Ala Thr Val Glu Asp Tyr Leu His 
                725


<210>  3128
<211>  1577
<212>  DNA
<213>  Homo sapiens

<400>  3128
ttaaatgttg cttaatgtag ttttagggaa ttatactttt tctaaaattt ttttctgaca     60

taagtaccct ctaacactga aaggttgtcc cctctcaact gcatgctgaa tactggatcc    120

tagactcttg agagctaaat aaagtatatc ttttagctgc agtttcatat taaaaatgaa    180

tttttaacaa tctgcatatt tagatgaaat attagggaat agttactaaa tgtacaaaat    240

ggtataagaa atgtatgttc gtgtcctcat tatactccat tccataaggt agtaaaatac    300

ttgtctgttt ttcttacaga agttgattca agtcagttga gacgccagtt gtgtggagga    360

agtcaggccg ccatagaaag aatgatccac tttggacgag agctgcaagc aatgagtgaa    420

cagctaagga gagactgtgg caagaacact gcaaacaaaa aaatgttgaa ggatgcattc    480

agtctactag catattcaga tccctggaac agcccagttg gaaatcagct tgacccgatt    540

cagagagaac ctgtgtgctc agctcttaac agtgcaatat tagaaaccca caatctgcca    600

aagcaacctc cacttgccct agcaatggga caggccacac aatgtctagg actgatggct    660

cgatcaggaa ttggatcctg cgcatttgcc acagtggaag actacctaca ttagctatgc    720

atttcaagag ctcacactta tattgtggca tatagtcaac atggaagtag accagctctg    780

ctgatttgaa atttagattt tttaaattat gtactgggga caggtttttg tcgctttaca    840

ttgcttccta gtttacagca tgatgcaaat gattttctaa cttagtgtta ggagaaatta    900

ttttccatct ttaacctctt agttgtctaa gagttaaata ttactgaatt tcagacgttc    960

aaattgatca tcacaaatcc tttaaaacaa ttacctaaaa gaaaccaaaa atcctgcctt   1020

ctttgtgggg gaggggggag agaggggaag gaaatggaac aagttgtgtt tgtgttagca   1080

tgtgggtgat gtaaacttca aattgggaga tgttccgacc cccactccca tataagcatt   1140

caatcagtgt aacttgcaaa atgcataaac atccgacagt ttgaatttat agtgttgatg   1200

gaagaaatca tttttaatgt gtactgtaaa acttgaaata ctcaggagct gagtgaatat   1260

gtttgttgct acttacaatc ccgacctgtt agtcccagta gttttgtttt aacatggtct   1320

ttttcaactt tgtttcctgt ttaactacag atgacttctg ttgtagactc acaagtttaa   1380

ctgttgtatt ataacagtat tacatgtcaa cggtgtggtt atgaccttta tttatataaa   1440

aaccaaatat ttagtcaatt taccgtgtct taatttaatc tttgtacacc ttccattttt   1500

aagtgcttaa atgagtacta tattgcaata aaatgtagtg atataattaa ccagccatta   1560

aaaatttact tctacag                                                  1577


<210>  3129
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  3129

Met Ile His Phe Gly Arg Glu Leu Gln Ala Met Ser Glu Gln Leu Arg 
1               5                   10                  15


Arg Asp Cys Gly Lys Asn Thr Ala Asn Lys Lys Met Leu Lys Asp Ala 
            20                  25                  30


Phe Ser Leu Leu Ala Tyr Ser Asp Pro Trp Asn Ser Pro Val Gly Asn 
        35                  40                  45


Gln Leu Asp Pro Ile Gln Arg Glu Pro Val Cys Ser Ala Leu Asn Ser 
    50                  55                  60


Ala Ile Leu Glu Thr His Asn Leu Pro Lys Gln Pro Pro Leu Ala Leu 
65                  70                  75                  80


Ala Met Gly Gln Ala Thr Gln Cys Leu Gly Leu Met Ala Arg Ser Gly 
                85                  90                  95


Ile Gly Ser Cys Ala Phe Ala Thr Val Glu Asp Tyr Leu His 
            100                 105                 110


<210>  3130
<211>  3385
<212>  DNA
<213>  Homo sapiens

<400>  3130
ggaaacagcc gcgagagcag cggccgcggc ggccgccagc gcgccttccc ctcccgcgct     60

cccgcgtcgc ccccgccctc ggcgcctcgt ccccgggccg cgcgcccgcg ctccggccaa    120

cgttctctcc cggcctcccg ggcccgccgc ctactcccgc gtctccgagc tcctcaaccg    180

ccgcggtctc cctgggcgcg cggcccgccg cctgcttccg gggcgggcgg actgggcgcc    240

tggtgccggc ggccgcagcg acagcgcccc cgggaagcag aggaggaagg agagaagagg    300

tggaggtggc cgcaggctga gtcgcggccg ggatgtccgg gcagccgccg ccgccgccgc    360

cgcagcagca gcaacagcag cagcagctgt cgccgccacc gccggcggcc ttggccccag    420

tctccggagt cgtcctgccg gcgcccccgg ccgtcagcgc cggctcttct ccggccggct    480

cgcccggcgg cggtgcgggc ggcgaaggct taggggccgc ggcggccgcc ctgctcctcc    540

accctccgcc gccgccgccc ccggccaccg cggccccgcc gcccccgccg ccgcccccgc    600

ctccccctgc ctcagcggct gcccccgcca gcgggccgcc cgctcccccg ggccttgcag    660

cgggccccgg cccggctgga ggagccccga ccccagctct ggtggcgggc agcagcgccg    720

cggccccctt ccctcacggg gactcggccc tgaacgagca ggagaaggag ttgcagcggc    780

ggctgaagcg tctctacccg gccgtggacg aacaagagac gccgctgcct cggtcctgga    840

gcccgaagga caagttcagc tacatcggcc tctctcagaa caacctgcgg gtgcactaca    900

aaggtcatgg caaaacccca aaagatgccg cgtcagttcg agccacgcat ccaataccag    960

cagcctgtgg gatttattat tttgaagtaa aaattgtcag taagggaaga gatggttaca   1020

tgggaattgg tctttctgct caaggtgtga acatgaatag actaccaggt tgggataagc   1080

attcatatgg ttaccatggg gatgatggac attcgttttg ttcttctgga actggacaac   1140

cttatggacc aactttcact actggtgatg tcattggctg ttgtgttaat cttatcaaca   1200

atacctgctt ttacaccaag aatggacata gtttaggtat tgctttcact gacctaccgc   1260

caaatttgta tcctactgtg gggcttcaaa caccaggaga agtggtcgat gccaattttg   1320

ggcaacatcc tttcgtgttt gatatagaag actatatgcg ggagtggaga accaaaatcc   1380

aggcacagat agatcgattt cctatcggag atcgagaagg agaatggcag accatgatac   1440

aaaaaatggt ttcatcttat ttagtccacc atgggtactg tgccacagca gaggcctttg   1500

ccagatctac agaccagacc gttctagaag aattagcttc cattaagaat agacaaagaa   1560

ttcagaaatt ggtattagca ggaagaatgg gagaagccat tgaaacaaca caacagttat   1620

acccaagttt acttgaaaga aatcctaatc tccttttcac attaaaagtg cgtcagttta   1680

tagaaatggt gaatggtaca gatagtgaag tacgatgttt gggaggccga agtccaaagt   1740

ctcaagacag ttatcctgtt agtcctcgac cttttagtag tccaagtatg agccccagcc   1800

atggaatgaa tatccacaat ttagcatcag gcaaaggaag caccgcacat ttttcaggtt   1860

ttgaaagttg tagtaatggt gtaatatcaa ataaagcaca tcaatcatat tgccatagta   1920

ataaacacca gtcatccaac ttgaatgtac cagaactaaa cagtataaat atgtcaagat   1980

cacagcaagt taataacttc accagtaatg atgtagacat ggaaacagat cactactcca   2040

atggagttgg agaaacttca tccaatggtt tcctaaatgg tagctctaaa catgaccacg   2100

aaatggaaga ttgtgacacc gaaatggaag ttgattcaag tcagttgaga cgccagttgt   2160

gtggaggaag tcaggccgcc atagaaagaa tgatccactt tggacgagag ctgcaagcaa   2220

tgagtgaaca gctaaggaga gactgtggca agaacactgc aaacaaaaaa atgttgaagg   2280

atgcattcag tctactagca tattcagatc cctggaacag cccagttgga aatcagcttg   2340

acccgattca gagagaacct gtgtgctcag ctcttaacag tgcaatatta gaaacccaca   2400

atctgccaaa gcaacctcca cttgccctag caatgggaca ggccacacaa tgtctaggac   2460

tgatggctcg atcaggaatt ggatcctgcg catttgccac agtggaagac tacctacatt   2520

agctatgcat ttcaagagct cacacttata ttgtggcata tagtcaacat ggaagtagac   2580

cagctctgct gatttgaaat ttagattttt taaattatgt actggggaca ggtttttgtc   2640

gctttacatt gcttcctagt ttacagcatg atgcaaatga ttttctaact tagtgttagg   2700

agaaattatt ttccatcttt aacctcttag ttgtctaaga gttaaatatt actgaatttc   2760

agacgttcaa attgatcatc acaaatcctt taaaacaatt acctaaaaga aaccaaaaat   2820

cctgccttct ttgtggggga ggggggagag aggggaagga aatggaacaa gttgtgtttg   2880

tgttagcatg tgggtgatgt aaacttcaaa ttgggagatg ttccgacccc cactcccata   2940

taagcattca atcagtgtaa cttgcaaaat gcataaacat ccgacagttt gaatttatag   3000

tgttgatgga agaaatcatt tttaatgtgt actgtaaaac ttgaaatact caggagctga   3060

gtgaatatgt ttgttgctac ttacaatccc gacctgttag tcccagtagt tttgttttaa   3120

catggtcttt ttcaactttg tttcctgttt aactacagat gacttctgtt gtagactcac   3180

aagtttaact gttgtattat aacagtatta catgtcaacg gtgtggttat gacctttatt   3240

tatataaaaa ccaaatattt agtcaattta ccgtgtctta atttaatctt tgtacacctt   3300

ccatttttaa gtgcttaaat gagtactata ttgcaataaa atgtagtgat ataattaacc   3360

agccattaaa aatttacttc tacag                                         3385


<210>  3131
<211>  729
<212>  PRT
<213>  Homo sapiens

<400>  3131

Met Ser Gly Gln Pro Pro Pro Pro Pro Pro Gln Gln Gln Gln Gln Gln 
1               5                   10                  15


Gln Gln Leu Ser Pro Pro Pro Pro Ala Ala Leu Ala Pro Val Ser Gly 
            20                  25                  30


Val Val Leu Pro Ala Pro Pro Ala Val Ser Ala Gly Ser Ser Pro Ala 
        35                  40                  45


Gly Ser Pro Gly Gly Gly Ala Gly Gly Glu Gly Leu Gly Ala Ala Ala 
    50                  55                  60


Ala Ala Leu Leu Leu His Pro Pro Pro Pro Pro Pro Pro Ala Thr Ala 
65                  70                  75                  80


Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Ser Ala Ala 
                85                  90                  95


Ala Pro Ala Ser Gly Pro Pro Ala Pro Pro Gly Leu Ala Ala Gly Pro 
            100                 105                 110


Gly Pro Ala Gly Gly Ala Pro Thr Pro Ala Leu Val Ala Gly Ser Ser 
        115                 120                 125


Ala Ala Ala Pro Phe Pro His Gly Asp Ser Ala Leu Asn Glu Gln Glu 
    130                 135                 140


Lys Glu Leu Gln Arg Arg Leu Lys Arg Leu Tyr Pro Ala Val Asp Glu 
145                 150                 155                 160


Gln Glu Thr Pro Leu Pro Arg Ser Trp Ser Pro Lys Asp Lys Phe Ser 
                165                 170                 175


Tyr Ile Gly Leu Ser Gln Asn Asn Leu Arg Val His Tyr Lys Gly His 
            180                 185                 190


Gly Lys Thr Pro Lys Asp Ala Ala Ser Val Arg Ala Thr His Pro Ile 
        195                 200                 205


Pro Ala Ala Cys Gly Ile Tyr Tyr Phe Glu Val Lys Ile Val Ser Lys 
    210                 215                 220


Gly Arg Asp Gly Tyr Met Gly Ile Gly Leu Ser Ala Gln Gly Val Asn 
225                 230                 235                 240


Met Asn Arg Leu Pro Gly Trp Asp Lys His Ser Tyr Gly Tyr His Gly 
                245                 250                 255


Asp Asp Gly His Ser Phe Cys Ser Ser Gly Thr Gly Gln Pro Tyr Gly 
            260                 265                 270


Pro Thr Phe Thr Thr Gly Asp Val Ile Gly Cys Cys Val Asn Leu Ile 
        275                 280                 285


Asn Asn Thr Cys Phe Tyr Thr Lys Asn Gly His Ser Leu Gly Ile Ala 
    290                 295                 300


Phe Thr Asp Leu Pro Pro Asn Leu Tyr Pro Thr Val Gly Leu Gln Thr 
305                 310                 315                 320


Pro Gly Glu Val Val Asp Ala Asn Phe Gly Gln His Pro Phe Val Phe 
                325                 330                 335


Asp Ile Glu Asp Tyr Met Arg Glu Trp Arg Thr Lys Ile Gln Ala Gln 
            340                 345                 350


Ile Asp Arg Phe Pro Ile Gly Asp Arg Glu Gly Glu Trp Gln Thr Met 
        355                 360                 365


Ile Gln Lys Met Val Ser Ser Tyr Leu Val His His Gly Tyr Cys Ala 
    370                 375                 380


Thr Ala Glu Ala Phe Ala Arg Ser Thr Asp Gln Thr Val Leu Glu Glu 
385                 390                 395                 400


Leu Ala Ser Ile Lys Asn Arg Gln Arg Ile Gln Lys Leu Val Leu Ala 
                405                 410                 415


Gly Arg Met Gly Glu Ala Ile Glu Thr Thr Gln Gln Leu Tyr Pro Ser 
            420                 425                 430


Leu Leu Glu Arg Asn Pro Asn Leu Leu Phe Thr Leu Lys Val Arg Gln 
        435                 440                 445


Phe Ile Glu Met Val Asn Gly Thr Asp Ser Glu Val Arg Cys Leu Gly 
    450                 455                 460


Gly Arg Ser Pro Lys Ser Gln Asp Ser Tyr Pro Val Ser Pro Arg Pro 
465                 470                 475                 480


Phe Ser Ser Pro Ser Met Ser Pro Ser His Gly Met Asn Ile His Asn 
                485                 490                 495


Leu Ala Ser Gly Lys Gly Ser Thr Ala His Phe Ser Gly Phe Glu Ser 
            500                 505                 510


Cys Ser Asn Gly Val Ile Ser Asn Lys Ala His Gln Ser Tyr Cys His 
        515                 520                 525


Ser Asn Lys His Gln Ser Ser Asn Leu Asn Val Pro Glu Leu Asn Ser 
    530                 535                 540


Ile Asn Met Ser Arg Ser Gln Gln Val Asn Asn Phe Thr Ser Asn Asp 
545                 550                 555                 560


Val Asp Met Glu Thr Asp His Tyr Ser Asn Gly Val Gly Glu Thr Ser 
                565                 570                 575


Ser Asn Gly Phe Leu Asn Gly Ser Ser Lys His Asp His Glu Met Glu 
            580                 585                 590


Asp Cys Asp Thr Glu Met Glu Val Asp Ser Ser Gln Leu Arg Arg Gln 
        595                 600                 605


Leu Cys Gly Gly Ser Gln Ala Ala Ile Glu Arg Met Ile His Phe Gly 
    610                 615                 620


Arg Glu Leu Gln Ala Met Ser Glu Gln Leu Arg Arg Asp Cys Gly Lys 
625                 630                 635                 640


Asn Thr Ala Asn Lys Lys Met Leu Lys Asp Ala Phe Ser Leu Leu Ala 
                645                 650                 655


Tyr Ser Asp Pro Trp Asn Ser Pro Val Gly Asn Gln Leu Asp Pro Ile 
            660                 665                 670


Gln Arg Glu Pro Val Cys Ser Ala Leu Asn Ser Ala Ile Leu Glu Thr 
        675                 680                 685


His Asn Leu Pro Lys Gln Pro Pro Leu Ala Leu Ala Met Gly Gln Ala 
    690                 695                 700


Thr Gln Cys Leu Gly Leu Met Ala Arg Ser Gly Ile Gly Ser Cys Ala 
705                 710                 715                 720


Phe Ala Thr Val Glu Asp Tyr Leu His 
                725


<210>  3132
<211>  1717
<212>  DNA
<213>  Homo sapiens

<400>  3132
gccgccgccg cccccggcca ccgcggcccc gccgcccccg ccgccgcccc cgcctccccc     60

tgcctcagcg gctgcccccg ccagcgggcc gcccgctccc ccgggccttg cagcgggccc    120

cggcccggct ggaggagccc cgaccccagc tctggtggcg ggcagcagcg ccgcggcccc    180

cttccctcac ggggactcgg ccctgaacga gcaggagaag gagttgcagc ggcggctgaa    240

gcgtctctac ccggccgtgg acgaacaaga gacgccgctg cctcggtcct ggagcccgaa    300

ggacaagttc agctacatcg gcctctctca gaacaacctg cgggtgcact acaaaggtca    360

tggcaaaacc ccaaaagatg ccgcgtcagt tcgagccacg catccaatac cagcagcctg    420

tgggatttat tattttgaag taaaaattgt cagtaaggga agagatggtt acatgggaat    480

tggtctttct gctcaaggtg tgaacatgaa tagactacca ggttgggata agcattcata    540

tggttaccat ggggatgatg gacattcgtt ttgttcttct ggaactggac aaccttatgg    600

accaactttc actactggtg atgtcattgg ctgttgtgtt aatcttatca acaatacctg    660

cttttacacc aagaatggac atagtttagg tattgctttc actgacctac cgccaaattt    720

gtatcctact gtggggcttc aaacaccagg agaagtggtc gatgccaatt ttgggcaaca    780

tcctttcgtg tttgatatag aagactatat gcgggagtgg agaaccaaaa tccaggcaca    840

gatagatcga tttcctatcg gagatcgaga aggagaatgg cagaccatga tacaaaaaat    900

ggtttcatct tatttagtcc accatgggta ctgtgccaca gcagaggcct ttgccagatc    960

tacagaccag accgttctag aagaattagc ttccattaag aatagacaaa gaattcagaa   1020

attggtatta gcaggaagaa tgggagaagc cattgaaaca acacaacagt tatacccaag   1080

tttacttgaa agaaatccta atctcctttt cacattaaaa gtgcgtcagt ttatagaaat   1140

ggtgaatggt acagatagtg aagtacgatg tttgggaggc cgaagtccaa agtctcaaga   1200

cagttatcct gttagtcctc gaccttttag tagtccaagt atgagcccca gccatggaat   1260

gaatatccac aatttagcat caggcaaagg aagcaccgca catttttcag gttttgaaag   1320

ttgtagtaat ggtgtaatat caaataaagc acatcaatca tattgccata gtaataaaca   1380

ccagtcatcc aacttgaatg taccagaact aaacagtata aatatgtcaa gatcacagca   1440

agttaataac ttcaccagta atgatgtaga catggaaaca gatcactact ccaatggagt   1500

tggagaaact tcatccaatg gtttcctaaa tggtagctct aaacatgacc acgaaatgga   1560

agattgtgac accgaaatgg aagttgattc aagtcagttg agacgccagt tgtgtggagg   1620

aagtcaggcc gccatagaaa gaatgatcca ctttggacga gagctgcaag caatgagtga   1680

acagctaagg agagactgtg gcaagaacac tgcaaac                            1717


<210>  3133
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  3133

Met Gly Ile Gly Leu Ser Ala Gln Gly Val Asn Met Asn Arg Leu Pro 
1               5                   10                  15


Gly Trp Asp Lys His Ser Tyr Gly Tyr His Gly Asp Asp Gly His Ser 
            20                  25                  30


Phe Cys Ser Ser Gly Thr Gly Gln Pro Tyr Gly Pro Thr Phe Thr Thr 
        35                  40                  45


Gly Asp Val Ile Gly Cys Cys Val Asn Leu Ile Asn Asn Thr Cys Phe 
    50                  55                  60


Tyr Thr Lys Asn Gly His Ser Leu Gly Ile Ala Phe Thr Asp Leu Pro 
65                  70                  75                  80


Pro Asn Leu Tyr Pro Thr Val Gly Leu Gln Thr Pro Gly Glu Val Val 
                85                  90                  95


Asp Ala Asn Phe Gly Gln His Pro Phe Val Phe Asp Ile Glu Asp Tyr 
            100                 105                 110


Met Arg Glu Trp Arg Thr Lys Ile Gln Ala Gln Ile Asp Arg Phe Pro 
        115                 120                 125


Ile Gly Asp Arg Glu Gly Glu Trp Gln Thr Met Ile Gln Lys Met Val 
    130                 135                 140


Ser Ser Tyr Leu Val His His Gly Tyr Cys Ala Thr Ala Glu Ala Phe 
145                 150                 155                 160


Ala Arg Ser Thr Asp Gln Thr Val Leu Glu Glu Leu Ala Ser Ile Lys 
                165                 170                 175


Asn Arg Gln Arg Ile Gln Lys Leu Val Leu Ala Gly Arg Met Gly Glu 
            180                 185                 190


Ala Ile Glu Thr Thr Gln Gln Leu Tyr Pro Ser Leu Leu Glu Arg Asn 
        195                 200                 205


Pro Asn Leu Leu Phe Thr Leu Lys Val Arg Gln Phe Ile Glu Met Val 
    210                 215                 220


Asn Gly Thr Asp Ser Glu Val Arg Cys Leu Gly Gly Arg Ser Pro Lys 
225                 230                 235                 240


Ser Gln Asp Ser Tyr Pro Val Ser Pro Arg Pro Phe Ser Ser Pro Ser 
                245                 250                 255


Met Ser Pro Ser His Gly Met Asn Ile His Asn Leu Ala Ser Gly Lys 
            260                 265                 270


Gly Ser Thr Ala His Phe Ser Gly Phe Glu Ser Cys Ser Asn Gly Val 
        275                 280                 285


Ile Ser Asn Lys Ala His Gln Ser Tyr Cys His Ser Asn Lys His Gln 
    290                 295                 300


Ser Ser Asn Leu Asn Val Pro Glu Leu Asn Ser Ile Asn Met Ser Arg 
305                 310                 315                 320


Ser Gln Gln Val Asn Asn Phe Thr Ser Asn Asp Val Asp Met Glu Thr 
                325                 330                 335


Asp His Tyr Ser Asn Gly Val Gly Glu Thr Ser Ser Asn Gly Phe Leu 
            340                 345                 350


Asn Gly Ser Ser Lys His Asp His Glu Met Glu Asp Cys Asp Thr Glu 
        355                 360                 365


Met Glu Val Asp Ser Ser Gln Leu Arg Arg Gln Leu Cys Gly Gly Ser 
    370                 375                 380


Gln Ala Ala Ile Glu Arg Met Ile His Phe Gly Arg Glu Leu Gln Ala 
385                 390                 395                 400


Met Ser Glu Gln Leu Arg Arg Asp Cys Gly Lys Asn Thr Ala 
                405                 410


<210>  3134
<211>  1158
<212>  DNA
<213>  Homo sapiens

<400>  3134
ccccgccagc gggccgcccg ctcccccggg ccttgcagcg ggccccggcc cggctggagg     60

agccccgacc ccagctctgg tggcgggcag cagcgccgcg gcccccttcc ctcacgggga    120

ctcggccctg aacgagcagg agaaggagtt gcagcggcgg ctgaagcgtc tctacccggc    180

cgtggacgaa caagagacgc cgctgcctcg gtcctggagc ccgaaggaca agttcagcta    240

catcggcctc tctcagaaca acctgcgggt gcactacaaa ggtcatggca aaaccccaaa    300

agatgccgcg tcagttcgag ccacgcatcc aataccagca gcctgtggga tttattattt    360

tgaagtaaaa attgtcagta agggaagaga tgggtaagta aattttggtg agaaaaatcg    420

tttgctagtt tttttgtttt ggttcataat gtttatgatg taattggaaa gttggaatcc    480

tggaaatttt gctaattgga aaagtggaat ctgaatattt cagtataaca gattggatct    540

ggttatgctt aaatactagc tgaagttaaa gcttgagttg gtgatattaa ctaagctttt    600

ctggtaggtt tattattaaa atggagaatt tggaattaag gaatgaaggg atggtgactc    660

attttccatg acttttctta cactgctttt tcgtgaattc tgctaagaag ttaaatcctc    720

tcaaactagt aatcatagtc agttggtgat tcataggtat tttacagatg ttggacttag    780

aattttaggt ttcagctggg aaatgtgtat ttgtatgctc tcaactagag gagattttca    840

aggtttagga tgtggtttag aaatttccaa atgagaattc catggtaggg cctggaacca    900

aattttatat cattgctttt cagcttggga ttggtgtgtg gtttgtatgg gtatcagaat    960

tcacttatga gactattaaa aatatagtaa tttttgggcc ttaccccaaa agttcctaaa   1020

ttaggatttt cagaagtaga gctttgggca agataggcat tttgagaaag ctccacactg   1080

aattttggtg cctatccctg gttaagcact aattacctag aatcattgga tctatcctat   1140

agtatttcct gataactt                                                 1158


<210>  3135
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  3135

Met Val Gly Pro Gly Thr Lys Phe Tyr Ile Ile Ala Phe Gln Leu Gly 
1               5                   10                  15


Ile Gly Val Trp Phe Val Trp Val Ser Glu Phe Thr Tyr Glu Thr Ile 
            20                  25                  30


Lys Asn Ile Val Ile Phe Gly Pro Tyr Pro Lys Ser Ser 
        35                  40                  45


<210>  3136
<211>  1190
<212>  DNA
<213>  Homo sapiens

<400>  3136
gcgcgcccgg caggaaaggg cggtcctgcg ctgtggccca cgctcgctcc cgctgtcgga     60

ctctgggcct ggaccgcgcg tggccggcgc caaaagcgag aggcatgagc gcgcgcccgg    120

gccagtgaac tgctcgggga tggactgcgg ctcggtcggc ggccagagga cccagcgcct    180

gcccggccgc cagcggcttc tcttcttgcc cgtgggcctc agcggaagac cgggcggcag    240

cgaaacctca gcacgccgct gcctctctgc gctctccgac ggtctggggg cgctgcgccc    300

tcgcgccccg gcggcccgcg gcggcgtgtc acgtgcctca ccgctgctcc tcctcctgct    360

agtgccctcc ccgcgcttgg ccgccgcagc cccgcgccgg cagctcgggg actgggagcg    420

ctcgcgcctc gggtatgccg cacccccggc cgggcgcagc agcgcgtgga ggtgctcacc    480

gggcgtcgcc gctgccgccg gcgcccttcc ccagtaccac ggcccggcgc ctgcactcgt    540

ttcctgcagg agagagctaa gcttgtctgc tggatccctg cagctggagc gcaaaaggag    600

agatttcacc tcttctggga gcaggaaact ctacttcgac actcatgcct tagtgtgctt    660

actggaagac aatgggtttg ctactcaaca agcagaaatc attgtgtctg cattggtcaa    720

gatcctggag gccaacatgg acatcgtcta caaagatatg gtcaccaaga tgcagcagga    780

aatcactttt cagcaagtaa tgtctcagat tgcgaatgtg aaaaaggata tgattatttt    840

ggagaagagt gaattttcag ccctcagagc agaaaatgag aaaataaaac tcgaactaca    900

tcagttaaaa caacaagtaa tggatgaagt gatcaaagtc cgaacagata ccaaattaga    960

cttcaaccta gaaaagagca gagtaaaaga attggaggaa attgggaatc tctgaacaat   1020

ccgtgggctg aatacgaagg aatctgcctg gcttcttgga tacacacttc atactctcaa   1080

ggacagccct ctttattgga atgcacaaag tatgtggaaa agagatacca tgtcttgtcg   1140

gattcaattt tgctcctaac atagtgtgga ttaaagagta atcaatagtg              1190


<210>  3137
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  3137

Met Asp Cys Gly Ser Val Gly Gly Gln Arg Thr Gln Arg Leu Pro Gly 
1               5                   10                  15


Arg Gln Arg Leu Leu Phe Leu Pro Val Gly Leu Ser Gly Arg Pro Gly 
            20                  25                  30


Gly Ser Glu Thr Ser Ala Arg Arg Cys Leu Ser Ala Leu Ser Asp Gly 
        35                  40                  45


Leu Gly Ala Leu Arg Pro Arg Ala Pro Ala Ala Arg Gly Gly Val Ser 
    50                  55                  60


Arg Ala Ser Pro Leu Leu Leu Leu Leu Leu Val Pro Ser Pro Arg Leu 
65                  70                  75                  80


Ala Ala Ala Ala Pro Arg Arg Gln Leu Gly Asp Trp Glu Arg Ser Arg 
                85                  90                  95


Leu Gly Tyr Ala Ala Pro Pro Ala Gly Arg Ser Ser Ala Trp Arg Cys 
            100                 105                 110


Ser Pro Gly Val Ala Ala Ala Ala Gly Ala Leu Pro Gln Tyr His Gly 
        115                 120                 125


Pro Ala Pro Ala Leu Val Ser Cys Arg Arg Glu Leu Ser Leu Ser Ala 
    130                 135                 140


Gly Ser Leu Gln Leu Glu Arg Lys Arg Arg Asp Phe Thr Ser Ser Gly 
145                 150                 155                 160


Ser Arg Lys Leu Tyr Phe Asp Thr His Ala Leu Val Cys Leu Leu Glu 
                165                 170                 175


Asp Asn Gly Phe Ala Thr Gln Gln Ala Glu Ile Ile Val Ser Ala Leu 
            180                 185                 190


Val Lys Ile Leu Glu Ala Asn Met Asp Ile Val Tyr Lys Asp Met Val 
        195                 200                 205


Thr Lys Met Gln Gln Glu Ile Thr Phe Gln Gln Val Met Ser Gln Ile 
    210                 215                 220


Ala Asn Val Lys Lys Asp Met Ile Ile Leu Glu Lys Ser Glu Phe Ser 
225                 230                 235                 240


Ala Leu Arg Ala Glu Asn Glu Lys Ile Lys Leu Glu Leu His Gln Leu 
                245                 250                 255


Lys Gln Gln Val Met Asp Glu Val Ile Lys Val Arg Thr Asp Thr Lys 
            260                 265                 270


Leu Asp Phe Asn Leu Glu Lys Ser Arg Val Lys Glu Leu Glu Glu Ile 
        275                 280                 285


Gly Asn Leu 
    290


<210>  3138
<211>  2239
<212>  DNA
<213>  Homo sapiens

<400>  3138
ctttggcaca tagaggattt gggggtctcc atgttcaggg cacaatggct ttaataagtg     60

ctggaaaatc actgaagcta aaccaagagc accagatcct ctttacctaa ataaccagtc    120

tttaacatga gctagtccct gtaccatagt attgtttcag ctgtagttgg ttgtcatgtt    180

aataagacag ctgcacgtct accttctttt cttttgattt ccattgtctt ggtaagttat    240

tgttagggtt atttttaatg tgccttccag ccagaaaaat cagctgtcta aagaagcatt    300

gcaattgtaa tggggactct tacctcttag aatgcaagat tttccctcct ccctccctct    360

tctccatctc tttccctcat gatttgagaa ctgtaataat cctccactgg tggcattacc    420

tacctagaaa acctgctgat tcttagcatg gaactttgct tcagtttgca ggacaaagtc    480

tgcttccttc cggtcttcat ttacttttta tacaagggat gcagtcagct ctccatgtat    540

aagataccta gatgatggat acatatttca taaatgaaat ttatgtcatt aatgaatatc    600

cccttgccca caaccagctc aggctttcaa aattcgagaa tggtcatgcc acacagcatt    660

ctaatctaga tggattaatt ctgttgttca aaacattctc atacctgcct ttatattgaa    720

aacaaattct agatacaact ggggttattc tggaaaagca cattctcacc tttttttttt    780

ttttgagacg gagtctcgca ctgtcgcagg gctggagtgc attgttgcag tgagcagaga    840

ttacaccact gcaacgagac tcgggcccag acgagatctg cctgggcgac acagtgagac    900

tctgtctcaa aataaataaa taagtaaata gaacctcctg agctaccctg gcttataagg    960

attcagatta ctttaggaaa ttaggcatta gcactaggag gggggaagat ggctggcaaa   1020

acttctagct agcaacctat gtctagcaca tgggtaacta accatagcga gatcctgaac   1080

acatatcctc taggtgcagg tggagggaac gatgtccaat acctgaagca gaatctcaca   1140

tggacggaac gtctgtattt ccctctcctg cacgaatcac tcatcattct tggagggctt   1200

ctctgcattc ctccttttct tctctcccct cccctgcctt ttgtcttttc taaagagtct   1260

gaactccgat ttccatgctc tcctgctaca ttaataagca aaacctgctt gtgtgtacgg   1320

ttctttactg gaaacatgac tttttgtttc tgtattggtt ttactgtcat ccagttttct   1380

agtttaatat ctagcaaaac taaatctgaa tgtactcgct ttttccgtta agtatgccaa   1440

gcacctcggt tgaaaggctt gactcaaacc agaagtcttg ctggaattcg tctctgaaca   1500

cttgaaaaac agaaaccctg agccgcaaca aacatgcctc tgtgtgtcgg gattgccttt   1560

gtctctgctt ccatgtggct tttccttttg tagctatgct tagtgacata atcttccctc   1620

ttctagcctt ctcctttcaa gcctgtctgt taattaacca tgtcagtatt ggcaagcatt   1680

tatcttcccc caccctaaca tgcaatcttc taagaatttt gcaaaattct aaacaaatat   1740

agagatggta tatagaattc atatctagaa aactttgatt ttaatgtgag cttatcaaat   1800

ttgttctggc ttttttggca ctaaggcaaa aacatgttaa ccagaaataa tttattcttc   1860

atgtatgtaa aatatttgag aatgtttagc cttttattag aattttattt ggaaaatatt   1920

tatctttcta cacattttac acttatgttc ctttgcttat aacccaattt cttaactttt   1980

ttgttactta agcaaatatc aattatgttt tattatctaa taaagtgtaa gattcttact   2040

atctaaaata tttaattctg tgtgactaat atacttttct gatcattcaa attgaatatg   2100

aaaagctaga ataactgtat tgcaactgtt aattccagcc aattgtataa tgataacact   2160

ggtgaatttc taagtaaatc taatacttga aaatttgggt atacatagaa aataaatttt   2220

aatataatgt acaaagtaa                                                2239


<210>  3139
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  3139

Met Ser Ser Thr Trp Val Thr Asn His Ser Glu Ile Leu Asn Thr Tyr 
1               5                   10                  15


Pro Leu Gly Ala Gly Gly Gly Asn Asp Val Gln Tyr Leu Lys Gln Asn 
            20                  25                  30


Leu Thr Trp Thr Glu Arg Leu Tyr Phe Pro Leu Leu His Glu Ser Leu 
        35                  40                  45


Ile Ile Leu Gly Gly Leu Leu Cys Ile Pro Pro Phe Leu Leu Ser Pro 
    50                  55                  60


Pro Leu Pro Phe Val Phe Ser Lys Glu Ser Glu Leu Arg Phe Pro Cys 
65                  70                  75                  80


Ser Pro Ala Thr Leu Ile Ser Lys Thr Cys Leu Cys Val Arg Phe Phe 
                85                  90                  95


Thr Gly Asn Met Thr Phe Cys Phe Cys Ile Gly Phe Thr Val Ile Gln 
            100                 105                 110


Phe Ser Ser Leu Ile Ser Ser Lys Thr Lys Ser Glu Cys Thr Arg Phe 
        115                 120                 125


Phe Arg 
    130


<210>  3140
<211>  2053
<212>  DNA
<213>  Homo sapiens

<400>  3140
ctttggcaca tagaggattt gggggtctcc atgttcaggg cacaatggct ttaataagtg     60

ctggaaaatc actgaagcta aaccaagagc accagatcct ctttacctaa ataaccagtc    120

tttaacatga gctagtccct gtaccatagt attgtttcag ctgtagttgg ttgtcatgtt    180

aataagacag ctgcacgtct accttctttt cttttgattt ccattgtctt ggtaagttat    240

tgttagggtt atttttaatg tgccttccag ccagaaaaat cagctgtcta aagaagcatt    300

gcaattgtaa tggggactct tacctcttag aatgcaagat tttccctcct ccctccctct    360

tctccatctc tttccctcat gatttgagaa ctgtaataat cctccactgg tggcattacc    420

tacctagaaa acctgctgat tcttagcatg gaactttgct tcagtttgca ggacaaagtc    480

tgcttccttc cggtcttcat ttacttttta tacaagggat gcagtcagct ctccatgtat    540

aagataccta gatgatggat acatatttca taaatgaaat ttatgtcatt aatgaatatc    600

cccttgccca caaccagctc aggctttcaa aattcgagaa tggtcatgcc acacagcatt    660

ctaatctaga tggattaatt ctgttgttca aaacattctc atacctgcct ttatattgaa    720

aacaaattct agatacaact ggggttattc tggaaaagca cattctcacc tttttttttt    780

ttttgagacg gagtctcgca ctgtcgcagg gctggagtgc attgttgcag tgagcagaga    840

ttacaccact gcaacgagac tcgggcccag acgagatctg cctgggcgac acagtgagac    900

tctgtctcaa aataaataaa taagtaaata gaacctcctg agctaccctg gcttataagg    960

attcagatta ctttaggaaa ttaggcatta gcactaggag gggggaagat ggctggcaaa   1020

acttctagct agcaacctat gtctagcaca tgggtaacta accatagcga gatcctgaac   1080

acatatcctc taggtgcagg tggagggaac gatgtccaat acctgaagca gaatctcaca   1140

tggacggaac gtctgtattt ccctctcctg cacgaatcac tcatcattct tggagggctt   1200

ctctgcattc ctccttttct tctctcccct cccctgcctt ttgtcttttc taaagagtct   1260

gaactccgat ttccatgctc tcctgctaca ttaataagca aaacctgctt gtgtgtacgg   1320

ttctttactg gaaacatgac tttttgtttc tgtattggtt ttactgtcat ccagttttct   1380

agtttaatat ctagcaaaac taaatctgaa tgtactcgct ttttccgtta agtatgccaa   1440

gcacctcggt tgaaaggctt gactcaaacc agaagtcttg ctggaattcg tctctgaaca   1500

cttgaaaaac agaaaccctg agccgcaaca aacatgcctc tgtgtgtcgg gattgccttt   1560

gtctctgctt ccatgtggct tttccttttg tagctatgct tagtgacata atcttccctc   1620

ttctagcctt ctcctttcaa gcctgtctgt taattaacca tgtcagtatt ggcaagcatt   1680

tatcttcccc caccctaaca tgcaatcttc taagaatttt gcaaaattct aaacaaatat   1740

agagatggta tatagaattc atatctagaa aactttgatt ttaatgtgag cttatcaaat   1800

ttgttctggc ttttttggca ctaaggcaaa aacatgttaa ccagaaataa tttattcttc   1860

atgtatgtaa aatatttgag aatgtttagc cttttattag aattttattt ggaaaatatt   1920

tatctttcta cacattttac acttatgttc ctttgcttat aacccaattt cttaactttt   1980

ttgttactta agcaaatatc aattatgttt tattatctaa taaagtgtaa gattcttact   2040

atctaaaata ttt                                                      2053


<210>  3141
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  3141

Met Ser Ser Thr Trp Val Thr Asn His Ser Glu Ile Leu Asn Thr Tyr 
1               5                   10                  15


Pro Leu Gly Ala Gly Gly Gly Asn Asp Val Gln Tyr Leu Lys Gln Asn 
            20                  25                  30


Leu Thr Trp Thr Glu Arg Leu Tyr Phe Pro Leu Leu His Glu Ser Leu 
        35                  40                  45


Ile Ile Leu Gly Gly Leu Leu Cys Ile Pro Pro Phe Leu Leu Ser Pro 
    50                  55                  60


Pro Leu Pro Phe Val Phe Ser Lys Glu Ser Glu Leu Arg Phe Pro Cys 
65                  70                  75                  80


Ser Pro Ala Thr Leu Ile Ser Lys Thr Cys Leu Cys Val Arg Phe Phe 
                85                  90                  95


Thr Gly Asn Met Thr Phe Cys Phe Cys Ile Gly Phe Thr Val Ile Gln 
            100                 105                 110


Phe Ser Ser Leu Ile Ser Ser Lys Thr Lys Ser Glu Cys Thr Arg Phe 
        115                 120                 125


Phe Arg 
    130


<210>  3142
<211>  489
<212>  DNA
<213>  Homo sapiens

<400>  3142
cctcaagtaa cacatataaa gaagcagtat tcattgaacg aaaagaagct gctggaattg     60

agaacagaaa tagtggcatt gcatgcccag caagatcggg cccttaccca gacagacagg    120

aagatcgaaa ctgaggttgc tggcctcaaa accatgcttg agtcacacaa gcttgataat    180

attaaatatt tagcagggtc tatatttacg tgcctaacag tagctctggg attttatcgc    240

ctgtggatct aataaagtgt ctatttaaag tgatttctac tgttttgcct taagaatacc    300

agattgttgg ctgggtgcgg tggctcacac ctgtaattcc agcactttgg gaggctgagg    360

caggtggatt acctgaggtc aggagttcga gaccagcctg gccaacacgg tgaaaccccg    420

tctctactaa aaaattaaaa cattaggcgg gcgtggtggc gggcgcctgt agtcccagct    480

actcgggag                                                            489


<210>  3143
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  3143

Met Leu Glu Ser His Lys Leu Asp Asn Ile Lys Tyr Leu Ala Gly Ser 
1               5                   10                  15


Ile Phe Thr Cys Leu Thr Val Ala Leu Gly Phe Tyr Arg Leu Trp Ile 
            20                  25                  30


<210>  3144
<211>  1456
<212>  DNA
<213>  Homo sapiens

<400>  3144
gcgcgcccgg caggaaaggg cggtcctgcg ctgtggccca cgctcgctcc cgctgtcgga     60

ctctgggcct ggaccgcgcg tggccggcgc caaaagcgag aggcatgagc gcgcgcccgg    120

gccagtgaac tgctcgggga tggactgcgg ctcggtcggc ggccagagga cccagcgcct    180

gcccggccgc cagcggcttc tcttcttgcc cgtgggcctc agcggaagac cgggcggcag    240

cgaaacctca gcacgccgct gcctctctgc gctctccgac ggtctggggg cgctgcgccc    300

tcgcgccccg gcggcccgcg gcggcgtgtc acgtgcctca ccgctgctcc tcctcctgct    360

agtgccctcc ccgcgcttgg ccgccgcagc cccgcgccgg cagctcgggg actgggagcg    420

ctcgcgcctc gggtatgccg cacccccggc cgggcgcagc agcgcgtgga ggtgctcacc    480

gggcgtcgcc gctgccgccg gcgcccttcc ccagtaccac ggcccggcgc ctgcactcgt    540

ttcctgcagg agagagctaa gcttgtctgc tggatccctg cagctggagc gcaaaaggag    600

agatttcacc tcttctggga gcaggaaact ctacttcgac actcatgcct tagtgtgctt    660

actggaagac aatgggtttg ctactcaaca agcagaaatc attgtgtctg cattggtcaa    720

gatcctggag gccaacatgg acatcgtcta caaagatatg gtcaccaaga tgcagcagga    780

aatcactttt cagcaagtaa tgtctcagat tgcgaatgtg aaaaaggata tgattatttt    840

ggagaagagt gaattttcag ccctcagagc agaaaatgag aaaataaaac tcgaactaca    900

tcagttaaaa caacaagtaa tggatgaagt gatcaaagtc cgaacagata ccaaattaga    960

cttcaaccta gaaaagagca gagtaaaaga attgtattca ttgaacgaaa agaagctgct   1020

ggaattgaga acagaaatag tggcattgca tgcccagcaa gatcgggccc ttacccagac   1080

agacaggaag atcgaaactg aggttgctgg cctcaaaacc atgcttgagt cacacaagct   1140

tgataatatt aaatatttag cagggtctat atttacgtgc ctaacagtag ctctgggatt   1200

ttatcgcctg tggatctaat aaagtgtcta tttaaagtga tttctactgt tttgccttaa   1260

gaataccaga ttgttggctg ggtgcggtgg ctcacacctg taattccagc actttgggag   1320

gctgaggcag gtggattacc tgaggtcagg agttcgagac cagcctggcc aacacggtga   1380

aaccccgtct ctactaaaaa attaaaacat taggcgggcg tggtggcggg cgcctgtagt   1440

cccagctact cgggag                                                   1456


<210>  3145
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  3145

Met Asp Cys Gly Ser Val Gly Gly Gln Arg Thr Gln Arg Leu Pro Gly 
1               5                   10                  15


Arg Gln Arg Leu Leu Phe Leu Pro Val Gly Leu Ser Gly Arg Pro Gly 
            20                  25                  30


Gly Ser Glu Thr Ser Ala Arg Arg Cys Leu Ser Ala Leu Ser Asp Gly 
        35                  40                  45


Leu Gly Ala Leu Arg Pro Arg Ala Pro Ala Ala Arg Gly Gly Val Ser 
    50                  55                  60


Arg Ala Ser Pro Leu Leu Leu Leu Leu Leu Val Pro Ser Pro Arg Leu 
65                  70                  75                  80


Ala Ala Ala Ala Pro Arg Arg Gln Leu Gly Asp Trp Glu Arg Ser Arg 
                85                  90                  95


Leu Gly Tyr Ala Ala Pro Pro Ala Gly Arg Ser Ser Ala Trp Arg Cys 
            100                 105                 110


Ser Pro Gly Val Ala Ala Ala Ala Gly Ala Leu Pro Gln Tyr His Gly 
        115                 120                 125


Pro Ala Pro Ala Leu Val Ser Cys Arg Arg Glu Leu Ser Leu Ser Ala 
    130                 135                 140


Gly Ser Leu Gln Leu Glu Arg Lys Arg Arg Asp Phe Thr Ser Ser Gly 
145                 150                 155                 160


Ser Arg Lys Leu Tyr Phe Asp Thr His Ala Leu Val Cys Leu Leu Glu 
                165                 170                 175


Asp Asn Gly Phe Ala Thr Gln Gln Ala Glu Ile Ile Val Ser Ala Leu 
            180                 185                 190


Val Lys Ile Leu Glu Ala Asn Met Asp Ile Val Tyr Lys Asp Met Val 
        195                 200                 205


Thr Lys Met Gln Gln Glu Ile Thr Phe Gln Gln Val Met Ser Gln Ile 
    210                 215                 220


Ala Asn Val Lys Lys Asp Met Ile Ile Leu Glu Lys Ser Glu Phe Ser 
225                 230                 235                 240


Ala Leu Arg Ala Glu Asn Glu Lys Ile Lys Leu Glu Leu His Gln Leu 
                245                 250                 255


Lys Gln Gln Val Met Asp Glu Val Ile Lys Val Arg Thr Asp Thr Lys 
            260                 265                 270


Leu Asp Phe Asn Leu Glu Lys Ser Arg Val Lys Glu Leu Tyr Ser Leu 
        275                 280                 285


Asn Glu Lys Lys Leu Leu Glu Leu Arg Thr Glu Ile Val Ala Leu His 
    290                 295                 300


Ala Gln Gln Asp Arg Ala Leu Thr Gln Thr Asp Arg Lys Ile Glu Thr 
305                 310                 315                 320


Glu Val Ala Gly Leu Lys Thr Met Leu Glu Ser His Lys Leu Asp Asn 
                325                 330                 335


Ile Lys Tyr Leu Ala Gly Ser Ile Phe Thr Cys Leu Thr Val Ala Leu 
            340                 345                 350


Gly Phe Tyr Arg Leu Trp Ile 
        355


<210>  3146
<211>  1825
<212>  DNA
<213>  Homo sapiens

<400>  3146
gcgcgcccgg caggaaaggg cggtcctgcg ctgtggccca cgctcgctcc cgctgtcgga     60

ctctgggcct ggaccgcgcg tggccggcgc caaaagcgag aggcatgagc gcgcgcccgg    120

gccagtgaac tgctcgggga tggactgcgg ctcggtcggc ggccagagga cccagcgcct    180

gcccggccgc cagcggcttc tcttcttgcc cgtgggcctc agcggaagac cgggcggcag    240

cgaaacctca gcacgccgct gcctctctgc gctctccgac ggtctggggg cgctgcgccc    300

tcgcgccccg gcggcccgcg gcggcgtgtc acgtgcctca ccgctgctcc tcctcctgct    360

agtgccctcc ccgcgcttgg ccgccgcagc cccgcgccgg cagctcgggg actgggagcg    420

ctcgcgcctc gggtatgccg cacccccggc cgggcgcagc agcgcgtgga ggtgctcacc    480

gggcgtcgcc gctgccgccg gcgcccttcc ccagtaccac ggcccggcgc ctgcactcgt    540

ttcctgcagg agagagctaa gcttgtctgc tggatccctg cagctggagc gcaaaaggag    600

agatttcacc tcttctggga gcaggaaact ctacttcgac actcatgcct tagtgtgctt    660

actggaagac aatgaatctc actctttcat ccaggctgga gtgcagtggc acagtcttgg    720

cctactgcaa cccccacctc ccggtttcaa gcgatcctcc cacctcatcc tcctgagtag    780

ctgggattac aggcatgcac caccacacct ggataatttt tctgtatttt tactagagac    840

ggggtttcac catgttggcc aggctggtct caaactgctg acctcaagtg atccacccac    900

cttggcctcc taaagtgctg ggattacagg cgtgaaccac tgtgtccagt tgccaaacct    960

aattatgttt aaacatgaac tcttttttta attaaaattt tttaaaattt tatttacatt   1020

aaaatggaga tgggatcact atgttgccca tgctggttct gaactcctgg gctcaaagat   1080

cctcccgcct tggtctccca gagtgttagg attacaggcg tgagccacca cacccagcca   1140

gtgaactctt cttaataaaa ctttaaaatt tggcaaaagt ttagtttgag tttttaaaaa   1200

ctaggaagac agacgagaaa aaagaaaaca gagtcagagc taaacaatgt taacattttg   1260

ggtttgctac tcaacaagca gaaatcattg tgtctgcatt ggtcaagatc ctggaggcca   1320

acatggacat cgtctacaaa gatatggtca ccaagatgca gcaggaaatc acttttcagc   1380

aagtaatgtc tcagattgcg aatgtgaaaa aggatatgat tattttggag aagagtgaat   1440

tttcagccct cagagcagaa aatgagaaaa taaaactcga actacatcag ttaaaacaac   1500

aagtaatgga tgaagtgatc aaagtccgaa cagataccaa attagacttc aacctagaaa   1560

agagcagagt aaaagaattg tattcattga acgaaaagaa gctgctggaa ttgagaacag   1620

aaatagtggc attgcatgcc cagcaagatc gggcccttac ccagacagac aggaagatcg   1680

aaactgaggt tgctggcctc aaaaccatgc ttgagtcaca caagcttgat aatattaaat   1740

atttagcagg gtctatattt acgtgcctaa cagtagctct gggattttat cgcctgtgga   1800

tctaataaag tgtctattta aagtg                                         1825


<210>  3147
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  3147

Met Asp Cys Gly Ser Val Gly Gly Gln Arg Thr Gln Arg Leu Pro Gly 
1               5                   10                  15


Arg Gln Arg Leu Leu Phe Leu Pro Val Gly Leu Ser Gly Arg Pro Gly 
            20                  25                  30


Gly Ser Glu Thr Ser Ala Arg Arg Cys Leu Ser Ala Leu Ser Asp Gly 
        35                  40                  45


Leu Gly Ala Leu Arg Pro Arg Ala Pro Ala Ala Arg Gly Gly Val Ser 
    50                  55                  60


Arg Ala Ser Pro Leu Leu Leu Leu Leu Leu Val Pro Ser Pro Arg Leu 
65                  70                  75                  80


Ala Ala Ala Ala Pro Arg Arg Gln Leu Gly Asp Trp Glu Arg Ser Arg 
                85                  90                  95


Leu Gly Tyr Ala Ala Pro Pro Ala Gly Arg Ser Ser Ala Trp Arg Cys 
            100                 105                 110


Ser Pro Gly Val Ala Ala Ala Ala Gly Ala Leu Pro Gln Tyr His Gly 
        115                 120                 125


Pro Ala Pro Ala Leu Val Ser Cys Arg Arg Glu Leu Ser Leu Ser Ala 
    130                 135                 140


Gly Ser Leu Gln Leu Glu Arg Lys Arg Arg Asp Phe Thr Ser Ser Gly 
145                 150                 155                 160


Ser Arg Lys Leu Tyr Phe Asp Thr His Ala Leu Val Cys Leu Leu Glu 
                165                 170                 175


Asp Asn Glu Ser His Ser Phe Ile Gln Ala Gly Val Gln Trp His Ser 
            180                 185                 190


Leu Gly Leu Leu Gln Pro Pro Pro Pro Gly Phe Lys Arg Ser Ser His 
        195                 200                 205


Leu Ile Leu Leu Ser Ser Trp Asp Tyr Arg His Ala Pro Pro His Leu 
    210                 215                 220


Asp Asn Phe Ser Val Phe Leu Leu Glu Thr Gly Phe His His Val Gly 
225                 230                 235                 240


Gln Ala Gly Leu Lys Leu Leu Thr Ser Ser Asp Pro Pro Thr Leu Ala 
                245                 250                 255


Ser 



<210>  3148
<211>  1239
<212>  DNA
<213>  Homo sapiens

<400>  3148
gcgcgcccgg caggaaaggg cggtcctgcg ctgtggccca cgctcgctcc cgctgtcgga     60

ctctgggcct ggaccgcgcg tggccggcgc caaaagcgag aggcatgagc gcgcgcccgg    120

gccagtgaac tgctcgggga tggactgcgg ctcggtcggc ggccagagga cccagcgcct    180

gcccggccgc cagcggcttc tcttcttgcc cgtgggcctc agcggaagac cgggcggcag    240

cgaaacctca gcacgccgct gcctctctgc gctctccgac ggtctggggg cgctgcgccc    300

tcgcgccccg gcggcccgcg gcggcgtgtc acgtgcctca ccgctgctcc tcctcctgct    360

agtgccctcc ccgcgcttgg ccgccgcagc cccgcgccgg cagctcgggg actgggagcg    420

ctcgcgcctc gggtatgccg cacccccggc cgggcgcagc agcgcgtgga ggtgctcacc    480

gggcgtcgcc gctgccgccg gcgcccttcc ccagtaccac ggcccggcgc ctgcactcgt    540

ttcctgcagg agagagctaa gcttgtctgc tggatccctg cagctggagc gcaaaaggag    600

agatttcacc tcttctggga gcaggaaact ctacttcgac actcatgcct tagtgtgctt    660

actggaagac aatgggtttg ctactcaaca agcagaaatc attgtgtctg cattggtcaa    720

gatcctggag gccaacatgg acatcgtcta caaagatatg gtcaccaaga tgcagcagga    780

aatcactttt cagcaagtaa tgtctcagat tgcgaatgtg aaaaaggata tgattatttt    840

ggagaagagt gaattttcag ccctcagagc agaaaatgag aaaataaaac tcgaactaca    900

tcagttaaaa caacaagtaa tggatgaagt gatcaaagtc cgaacagata ccaaattaga    960

cttcaaccta gaaaagagca gagtaaaaga attgtattca ttgaacgaaa agaagctgct   1020

ggaattgaga acagaaatag tggcattgca tgcccagcaa gatcgggccc ttacccagac   1080

agacaggaag atcgaaactg aggttgctgg cctcaaaacc atgcttgagt cacacaagct   1140

tgataatatt aaatatttag cagggtctat atttacgtgc ctaacagtag ctctgggatt   1200

ttatcgcctg tggatctaat aaagtgtcta tttaaagtg                          1239


<210>  3149
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  3149

Met Asp Cys Gly Ser Val Gly Gly Gln Arg Thr Gln Arg Leu Pro Gly 
1               5                   10                  15


Arg Gln Arg Leu Leu Phe Leu Pro Val Gly Leu Ser Gly Arg Pro Gly 
            20                  25                  30


Gly Ser Glu Thr Ser Ala Arg Arg Cys Leu Ser Ala Leu Ser Asp Gly 
        35                  40                  45


Leu Gly Ala Leu Arg Pro Arg Ala Pro Ala Ala Arg Gly Gly Val Ser 
    50                  55                  60


Arg Ala Ser Pro Leu Leu Leu Leu Leu Leu Val Pro Ser Pro Arg Leu 
65                  70                  75                  80


Ala Ala Ala Ala Pro Arg Arg Gln Leu Gly Asp Trp Glu Arg Ser Arg 
                85                  90                  95


Leu Gly Tyr Ala Ala Pro Pro Ala Gly Arg Ser Ser Ala Trp Arg Cys 
            100                 105                 110


Ser Pro Gly Val Ala Ala Ala Ala Gly Ala Leu Pro Gln Tyr His Gly 
        115                 120                 125


Pro Ala Pro Ala Leu Val Ser Cys Arg Arg Glu Leu Ser Leu Ser Ala 
    130                 135                 140


Gly Ser Leu Gln Leu Glu Arg Lys Arg Arg Asp Phe Thr Ser Ser Gly 
145                 150                 155                 160


Ser Arg Lys Leu Tyr Phe Asp Thr His Ala Leu Val Cys Leu Leu Glu 
                165                 170                 175


Asp Asn Gly Phe Ala Thr Gln Gln Ala Glu Ile Ile Val Ser Ala Leu 
            180                 185                 190


Val Lys Ile Leu Glu Ala Asn Met Asp Ile Val Tyr Lys Asp Met Val 
        195                 200                 205


Thr Lys Met Gln Gln Glu Ile Thr Phe Gln Gln Val Met Ser Gln Ile 
    210                 215                 220


Ala Asn Val Lys Lys Asp Met Ile Ile Leu Glu Lys Ser Glu Phe Ser 
225                 230                 235                 240


Ala Leu Arg Ala Glu Asn Glu Lys Ile Lys Leu Glu Leu His Gln Leu 
                245                 250                 255


Lys Gln Gln Val Met Asp Glu Val Ile Lys Val Arg Thr Asp Thr Lys 
            260                 265                 270


Leu Asp Phe Asn Leu Glu Lys Ser Arg Val Lys Glu Leu Tyr Ser Leu 
        275                 280                 285


Asn Glu Lys Lys Leu Leu Glu Leu Arg Thr Glu Ile Val Ala Leu His 
    290                 295                 300


Ala Gln Gln Asp Arg Ala Leu Thr Gln Thr Asp Arg Lys Ile Glu Thr 
305                 310                 315                 320


Glu Val Ala Gly Leu Lys Thr Met Leu Glu Ser His Lys Leu Asp Asn 
                325                 330                 335


Ile Lys Tyr Leu Ala Gly Ser Ile Phe Thr Cys Leu Thr Val Ala Leu 
            340                 345                 350


Gly Phe Tyr Arg Leu Trp Ile 
        355


<210>  3150
<211>  870
<212>  DNA
<213>  Homo sapiens

<400>  3150
gcgcgcccgg caggaaaggg cggtcctgcg ctgtggccca cgctcgctcc cgctgtcgga     60

ctctgggcct ggaccgcgcg tggccggcgc caaaagcgag aggcatgagc gcgcgcccgg    120

gccagtgaac tgctcgggga tggactgcgg ctcggtcggc ggccagagga cccagcgcct    180

gcccggccgc cagcggcttc tcttcttgcc cgtgggcctc agcggaagac cgggcggcag    240

cgaaacctca gcacgccgct gcctctctgc gctctccgac ggtctggggg cgctgcgccc    300

tcgcgccccg gcggcccgcg gcggcgtgtc acgtgcctca ccgctgctcc tcctcctgct    360

agtgccctcc ccgcgcttgg ccgccgcagc cccgcgccgg cagctcgggg actgggagcg    420

ctcgcgcctc gggtatgccg cacccccggc cgggcgcagc agcgcgtgga ggtgctcacc    480

gggcgtcgcc gctgccgccg gcgcccttcc ccagtaccac ggcccggcgc ctgcactcgt    540

ttcctgcagg agagagctaa gcttgtctgc tggatccctg cagctggagc gcaaaaggag    600

agatttcacc tcttctggga gcaggaaact ctacttcgac actcatgcct tagtgtgctt    660

actggaagac aatgggtttg ctactcaaca agcagaaatc attgtgtctg cattggtcaa    720

gatcctggag gccaacatgg acatcgtcta caaagatatg gtcaccaaga tgcagcagga    780

aatcactttt cagcaagtaa tgtctcagat tgcgaatgtg aaaaaggata tgattatttt    840

ggagaagagt gaattttcag ccctcagagc                                     870


<210>  3151
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  3151

Met Asp Cys Gly Ser Val Gly Gly Gln Arg Thr Gln Arg Leu Pro Gly 
1               5                   10                  15


Arg Gln Arg Leu Leu Phe Leu Pro Val Gly Leu Ser Gly Arg Pro Gly 
            20                  25                  30


Gly Ser Glu Thr Ser Ala Arg Arg Cys Leu Ser Ala Leu Ser Asp Gly 
        35                  40                  45


Leu Gly Ala Leu Arg Pro Arg Ala Pro Ala Ala Arg Gly Gly Val Ser 
    50                  55                  60


Arg Ala Ser Pro Leu Leu Leu Leu Leu Leu Val Pro Ser Pro Arg Leu 
65                  70                  75                  80


Ala Ala Ala Ala Pro Arg Arg Gln Leu Gly Asp Trp Glu Arg Ser Arg 
                85                  90                  95


Leu Gly Tyr Ala Ala Pro Pro Ala Gly Arg Ser Ser Ala Trp Arg Cys 
            100                 105                 110


Ser Pro Gly Val Ala Ala Ala Ala Gly Ala Leu Pro Gln Tyr His Gly 
        115                 120                 125


Pro Ala Pro Ala Leu Val Ser Cys Arg Arg Glu Leu Ser Leu Ser Ala 
    130                 135                 140


Gly Ser Leu Gln Leu Glu Arg Lys Arg Arg Asp Phe Thr Ser Ser Gly 
145                 150                 155                 160


Ser Arg Lys Leu Tyr Phe Asp Thr His Ala Leu Val Cys Leu Leu Glu 
                165                 170                 175


Asp Asn Gly Phe Ala Thr Gln Gln Ala Glu Ile Ile Val Ser Ala Leu 
            180                 185                 190


Val Lys Ile Leu Glu Ala Asn Met Asp Ile Val Tyr Lys Asp Met Val 
        195                 200                 205


Thr Lys Met Gln Gln Glu Ile Thr Phe Gln Gln Val Met Ser Gln Ile 
    210                 215                 220


Ala Asn Val Lys Lys Asp Met Ile Ile Leu Glu Lys Ser Glu Phe Ser 
225                 230                 235                 240


Ala Leu 



<210>  3152
<211>  438
<212>  DNA
<213>  Homo sapiens

<400>  3152
cagcttgagc tgagctttca ctcaccgtcc accactgctg tttgctgcca tcgcagactt     60

gccactgact tccacccctc cagatccagc agggtgtctg ctgctctcct gatccagcga    120

gatggattcc ctacaggact catgagcaga tctcataatt tctgggcatg ttccacacct    180

tggagtagga atcagttagg gttgttcttg gctgcaacta acaaactact agcagtggct    240

taagcacgga agaacttaat gatctcacag gtgacctggg tagggaaggg ccctggtcta    300

ctctacagct cttctagact ctctcacctt ggagtccaaa cgcatggcct tcctttggaa    360

caccttctct ctctcccact tcgggctcag ctcctttgca gtgaaagatt ggaaagaata    420

aacatctctt actcaatg                                                  438


<210>  3153
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  3153

Met Ile Ser Gln Val Thr Trp Val Gly Lys Gly Pro Gly Leu Leu Tyr 
1               5                   10                  15


Ser Ser Ser Arg Leu Ser His Leu Gly Val Gln Thr His Gly Leu Pro 
            20                  25                  30


Leu Glu His Leu Leu Ser Leu Pro Leu Arg Ala Gln Leu Leu Cys Ser 
        35                  40                  45


Glu Arg Leu Glu Arg Ile Asn Ile Ser Tyr Ser 
    50                  55


<210>  3154
<211>  1290
<212>  DNA
<213>  Homo sapiens

<400>  3154
cgtaggcaga aaaatagtat cattcatgtt gtactctttt atattcattc agtttttttc     60

ttaaacctac attatagttc tttctggttc tagttatttt ataaatatga tacagctata    120

gcaagttatg acctaacttg ttcacagtca ctatttatgt aaagaaatga ttcattcatt    180

tattcattgt gaattttttt aaaactactg catggtgctg tgggaatgga agtgaataag    240

agctaccgga aggcagttat tttcttcctg gtcaggcagg ggaaagaaga aactctctga    300

aataatgaat acgaatagaa tggggttcta acagtgttct aacagtgaag gaattcagaa    360

gagtgacgct gagtaggagt gatcaggaaa gactttgagg aggagggatc acttgagttg    420

agctctgctg actagattgc atttctgtgg gaagagatgg atggagcatg aggaaggcca    480

tgtgtgtgtc tgggacataa caagccaatg cacgcatact ggagcatagt gaaagagtct    540

attttgaagc ttcaaactta gtgctgctgc agaccaggaa caagagagaa agagtggatt    600

tcagcctgca cggatggtct tgaaacacaa atggtttttg gtctaggcgt tttacactga    660

gattctccac tgccaccctt tctactcaag caaaatcttc gtgaaaagat ctgctgcaag    720

gaactgatag cttatggttc tccattgtga tgaaagcaca tggtacagtt ttccaaagaa    780

attagaccat tttcttcgtg agaaagaaat cgacgtgctg ttttcatagg gtatttctca    840

cttctctgtg aaaggaagaa agaacacgcc tgagcccaag agccctcagg agccctccag    900

agcctgtggg aagtctccat ggtgaagtat aggctgaggc tacctgtgaa cagtacgcag    960

tgaatgttat ctgatgcaca aaggaaaata ataatacaaa acccataacc tattcattgt   1020

attgttgcgg tagatcgagc tacatgctgc acagcaaaag accttctttg cacttctttc   1080

aagcagaatt attgctgtat attcactctg aactgagaga tcattgcaaa aaaaaaaaag   1140

aagaagaaga agagaagaaa agaaaaaaga aataggttaa gcaaattttg tggtggtgct   1200

tatgtgtgca cagacatgca tgaggcctcc gcatcttcca aacttggaaa gcatatttta   1260

acagcacaaa tatatctaca tgtttgatct                                    1290


<210>  3155
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  3155

Met Leu His Ser Lys Arg Pro Ser Leu His Phe Phe Gln Ala Glu Leu 
1               5                   10                  15


Leu Leu Tyr Ile His Ser Glu Leu Arg Asp His Cys Lys Lys Lys Lys 
            20                  25                  30


Glu Glu Glu Glu Glu Lys Lys Arg Lys Lys Lys 
        35                  40


<210>  3156
<211>  886
<212>  DNA
<213>  Homo sapiens

<400>  3156
tttatgtgat gctttctctg gtctatctaa caaaatgtct taatgttaaa aatgctgggt     60

gccctccttt tttttcagca ctggtgtaga cttcccccca tctttatatt tgtgggaaat    120

ggatgttcag attgatgacg tgctctaaag acagagaggg gaaatttaca aaacacaaat    180

ggagaggaat gtgaatttta caaaagtatt tatggagttc tctaaataat gaactccctc    240

aggacactta gcacaccaag taatgtaaaa agttaggctt acacgtagat tgtcagacac    300

acagcttttg tatattgtaa gctacacctg tatccctgta atggtcccca ggagtatcac    360

gctgcatgta attgggcatt agtggaagca gttcacgtaa aagactataa tttgtattac    420

ttttacacca ttgcaacact ttttattgtt cctcagtcct tgatttgttt tctaatgtct    480

ctagtgtgtt taacactttc tcttgttatg atatgcacca tacatgtgca tgtaatataa    540

ttcacatata taacatgaaa acatctgatt cccacatcta acagtcagac ttccgttttc    600

ctcttttcca aaatccaggt ggtcagctgg gtgcagtggc ttgagtgtgt atttccagca    660

ctttgtgaag ccaaagtggg aggattgctt agggcaggag tttgagacta gcctgggcaa    720

catagtgagg cctcatctct acattttttt tttttaatca gccaggcatg gtgatgtgtg    780

cctgtggtcc cggctactca gaaggctgaa gtgggaggat cacctggttc caggaggctg    840

aggctgcagt gagctctgat tgtaccactg cactctagcc tgggca                   886


<210>  3157
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  3157

Met Leu Lys Met Leu Gly Ala Leu Leu Phe Phe Gln His Trp Cys Arg 
1               5                   10                  15


Leu Pro Pro Ile Phe Ile Phe Val Gly Asn Gly Cys Ser Asp 
            20                  25                  30


<210>  3158
<211>  2882
<212>  DNA
<213>  Homo sapiens

<400>  3158
atgcaagaac aaagagcaca gcaaagctgg acaaacacag caatccaggc aggggatttc     60

caactcaact ctggtatata agctgcatgc aaagtccttt ttctgtctct ggtttctggc    120

cccttgtctg cagagatggc tcccaatgct tcctgcctct gtgtgcatgt ccgttccgag    180

gaatgggatt taatgacctt tgatgccaac ccatatgaca gcgtgaaaaa aatcaaagaa    240

catgtccggt ctaagaccaa ggttcctgtg caggaccagg ttcttttgct gggctccaag    300

atcttaaagc cacggagaag cctctcatct tatggcattg acaaagagaa gaccatccac    360

cttaccctga aagtggtgaa gcccagtgat gaggagctgc ccttgtttct tgtggagtca    420

ggtgatgagg caaagaggca cctcctccag gtgcgaaggt ccagctcagt ggcacaagtg    480

aaagcaatga tcgagactaa gacgggtata atccctgaga cccagattgt gacttgcaat    540

ggaaagagac tggaagatgg gaagatgatg gcagattacg gcatcagaaa gggcaactta    600

ctcttcctgg catgttattg tattggaggg tgaccaccct gggcatgggg tgttggcagg    660

ggtcaaaaag cttatttctt ttaatctctt actcaacgaa cacatcttct gatgatttcc    720

caaaattaat gagaatgaga tgagtagagt aagatttggg tgggatgggt aggatgaagt    780

atattgccca actctatgtt tctttgattc taacacaatt aattaagtga catgattttt    840

actaatgtat tactgagact agtaaataaa tttttaaggc aaaatagagc attcaaagcc    900

agcttggaat ttaattctgt cttgatacct tgttatttat gcaaaaactc ctatctcctt    960

tcctttatga caagagagta agttttaggt tgggatccat gttctactga tttctgtatt   1020

tctgtctttg ttaagtccag tgctttattt atatcactca ataatggttg aaccaaattg   1080

aatttctact tatagagcat agtgaaatga tattttataa aatgaattag ttgctctgac   1140

atgatcacaa tcaaattact aaacatttta gaaactaaat taaactcctt cccccctctt   1200

ctcctttaaa gctatttgta tgaaatgaag tctggcacca tgcccccttt tattctctat   1260

gtctcacacc caactaaaat agttattatt tctggggatg atggtgggca aggaaaggta   1320

ttttccacag ggatctagca attctgttta actagtgggg attcctaggg gtagatggac   1380

attgggagcg aacaaacttt ctaaagctgg gggactgtgg accaccctct ctcctacctg   1440

ccttagggtc tagcaggtct tctccaggat gagggcgcca gtctgggtga gggtgggtga   1500

ggagctggct tctgggttga cctcaatatt ctgctcaggt tctgctgatt gagcattttc   1560

ctctcttctt tttttcatga ggagatccct gttcctgtct tgagaacttg agtcccttcc   1620

tccatcttcc tccctccatt tactcctctc tctgactctc tctcttgctc tctctctcat   1680

gactcactac tgatcacctg tgagtttttt tcacgggctg agacgtgccc gccttcttcc   1740

acactcatcc tagttccttg tttctttaaa acttgctcaa gaaccaactc ctgcaggggg   1800

gtttccagtc ttaaccccac tcagcaaaat tcaccaccat ttatgggctt tcctcatcac   1860

atttatgggt gaaatgcccc ggggagggca ctggtcatct ggccaggtct gcactaagtt   1920

ggactgattt ctgagaatag agtccatggt cgctttttct ggatgtaccc tctcctgcag   1980

ggtagggact atgattttct tgtcaacttg agacttctga ttgcagagac caagaggtct   2040

tccatggtct tccatcagat agggaggaag ctaaaggcga gcatcacgtc catcattttc   2100

cctgcgcgtg gagttgtgag gggtaggttt tccttcccta aacctgagta tatagaggat   2160

ttagggattt tccctcaaga actaaacatt tcctcacggg aggaaaacat atcccccatt   2220

ggactcctta ggacaaatct tgcagattat catacaaaaa tgaacagcct gaagtctaaa   2280

ctgactcact aaggggtatt tccatccttg ggttctggct taatactttc tcccctcccc   2340

aactactcac tgcccagcct ggcctctccc cagactccgc agcagcctcc tcgctgcccc   2400

cttcactttc ttattcctga gggtgtagat gagcgggttg agagcaggtg tgaccacggt   2460

gtagaagagc gatacgaact tgccccgtgc ctggttgtag cgctgcgcgg gctgcaggta   2520

ggtgtagatg gccgagccgt agaacaggca gacggctgtc aggtgggacc cacacgtgcc   2580

caccgccctc ctccggcctc cgctgaaccg catgcaacag acagctcggg ccacggcacc   2640

gtaggaggcc aggatgacgg caaacggcag cagcaggatg accacgcggg cggcgaacat   2700

ctggttctcg gtagtgtctc cgtcgcctcc gcaggccagc ttgagcaacg ccggcagctc   2760

acagatgaag tggtccagca ggcggggcgc gcacagcggc cgctcagcca ggagcgcggt   2820

ttgcgcaacc gagttggtga ggccgcttag ccaggaggcg ctggccagcg tgcgacatag   2880

gc                                                                  2882


<210>  3159
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  3159

Met Ala Pro Asn Ala Ser Cys Leu Cys Val His Val Arg Ser Glu Glu 
1               5                   10                  15


Trp Asp Leu Met Thr Phe Asp Ala Asn Pro Tyr Asp Ser Val Lys Lys 
            20                  25                  30


Ile Lys Glu His Val Arg Ser Lys Thr Lys Val Pro Val Gln Asp Gln 
        35                  40                  45


Val Leu Leu Leu Gly Ser Lys Ile Leu Lys Pro Arg Arg Ser Leu Ser 
    50                  55                  60


Ser Tyr Gly Ile Asp Lys Glu Lys Thr Ile His Leu Thr Leu Lys Val 
65                  70                  75                  80


Val Lys Pro Ser Asp Glu Glu Leu Pro Leu Phe Leu Val Glu Ser Gly 
                85                  90                  95


Asp Glu Ala Lys Arg His Leu Leu Gln Val Arg Arg Ser Ser Ser Val 
            100                 105                 110


Ala Gln Val Lys Ala Met Ile Glu Thr Lys Thr Gly Ile Ile Pro Glu 
        115                 120                 125


Thr Gln Ile Val Thr Cys Asn Gly Lys Arg Leu Glu Asp Gly Lys Met 
    130                 135                 140


Met Ala Asp Tyr Gly Ile Arg Lys Gly Asn Leu Leu Phe Leu Ala Cys 
145                 150                 155                 160


Tyr Cys Ile Gly Gly 
                165


<210>  3160
<211>  900
<212>  DNA
<213>  Homo sapiens

<400>  3160
atgcaagaac aaagagcaca gcaaagctgg acaaacacag caatccaggc aggggatttc     60

caactcaact ctggtatata agctgcatgc aaagtccttt ttctgtctct ggtttctggc    120

cccttgtctg cagagatggc tcccaatgct tcctgcctct gtgtgcatgt ccgttccgag    180

gaatgggatt taatgacctt tgatgccaac ccatatgaca gcgtgaaaaa aatcaaagaa    240

catgtccggt ctaagaccaa ggttcctgtg caggaccagg ttcttttgct gggctccaag    300

atcttaaagc cacggagaag cctctcatct tatggcattg acaaagagaa gaccatccac    360

cttaccctga aagtggtgaa gcccagtgat gaggagctgc ccttgtttct tgtggagtca    420

ggtgatgagg caaagaggca cctcctccag gtgcgaaggt ccagctcagt ggcacaagtg    480

aaagcaatga tcgagactaa gacgggtata atccctgaga cccagattgt gacttgcaat    540

ggaaagagac tggaagatgg gaagatgatg gcagattacg gcatcagaaa gggcaactta    600

ctcttcctgg catgttattg tattggaggg tgaccaccct gggcatgggg tgttggcagg    660

ggtcaaaaag cttatttctt ttaatctctt actcaacgaa cacatcttct gatgatttcc    720

caaaattaat gagaatgaga tgagtagagt aagatttggg tgggatgggt aggatgaagt    780

atattgccca actctatgtt tctttgattc taacacaatt aattaagtga catgattttt    840

actaatgtat tactgagact agtaaataaa tttttaaggc aaaatagagc attcaaagcc    900


<210>  3161
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  3161

Met Ala Pro Asn Ala Ser Cys Leu Cys Val His Val Arg Ser Glu Glu 
1               5                   10                  15


Trp Asp Leu Met Thr Phe Asp Ala Asn Pro Tyr Asp Ser Val Lys Lys 
            20                  25                  30


Ile Lys Glu His Val Arg Ser Lys Thr Lys Val Pro Val Gln Asp Gln 
        35                  40                  45


Val Leu Leu Leu Gly Ser Lys Ile Leu Lys Pro Arg Arg Ser Leu Ser 
    50                  55                  60


Ser Tyr Gly Ile Asp Lys Glu Lys Thr Ile His Leu Thr Leu Lys Val 
65                  70                  75                  80


Val Lys Pro Ser Asp Glu Glu Leu Pro Leu Phe Leu Val Glu Ser Gly 
                85                  90                  95


Asp Glu Ala Lys Arg His Leu Leu Gln Val Arg Arg Ser Ser Ser Val 
            100                 105                 110


Ala Gln Val Lys Ala Met Ile Glu Thr Lys Thr Gly Ile Ile Pro Glu 
        115                 120                 125


Thr Gln Ile Val Thr Cys Asn Gly Lys Arg Leu Glu Asp Gly Lys Met 
    130                 135                 140


Met Ala Asp Tyr Gly Ile Arg Lys Gly Asn Leu Leu Phe Leu Ala Cys 
145                 150                 155                 160


Tyr Cys Ile Gly Gly 
                165


<210>  3162
<211>  3712
<212>  DNA
<213>  Homo sapiens

<400>  3162
cgttcctttc ctcctcgagg ttgcatcccc cctcccctcc ccgcccctcc gactgtcgct     60

cccacctcgg cgctcgcttc cctccccgcc cccttcctgc ctccccagct cccgcccgcc    120

cccccacccc ccgctgccgc gcgccgcccg tgacgtcaga gccccctccc agccccacat    180

ctccctcctg ctcctcctcc tcccctccgt cggtcagtca gtccgcgagg agagtccgcg    240

gtggcggcga cggtggcgag agccgcgggg gccgtaggaa gccaaccttc cctgcttctc    300

cggggccctc gccccctcct ccccacaaaa tcagggatgg aggcgcctcc ccggcaccct    360

cttagcagcc ctccccagga aaagtgtccc ccctgagctc ctaacgctcc ccaacagcta    420

cccctgcccc ccacgccatg gggcccgggg ccccttttgc ccgggtgggg tggccactgc    480

cgcttctggt tgtgatggcg gcaggggtgg ctccggtgtg ggcctcccac tccccccatc    540

tcccgcggcc tcactcgcgg gtccccccgc acccctcctc agaacggcgc gcagtgtaca    600

tcggggcact gtttcccatg agcgggggct ggccaggggg ccaggcctgc cagcccgcgg    660

tggagatggc gctggaggac gtgaatagcc gcagggacat cctgccggac tatgagctca    720

agctcatcca ccacgacagc aagtgtgatc caggccaagc caccaagtac ctatatgagc    780

tgctctacaa cgaccctatc aagatcatcc ttatgcctgg ctgcagctct gtctccacgc    840

tggtggctga ggctgctagg atgtggaacc tcattgtgct ttcctatggc tccagctcac    900

cagccctgtc aaaccggcag cgtttcccca ctttcttccg aacgcaccca tcagccacac    960

tccacaaccc tacccgcgtg aaactctttg aaaagtgggg ctggaagaag attgctacca   1020

tccagcagac cactgaggtc ttcacttcga ctctggacga cctggaggaa cgagtgaagg   1080

aggctggaat tgagattact ttccgccaga gtttcttctc agatccagct gtgcccgtca   1140

aaaacctgaa gcgccaggat gcccgaatca tcgtgggact tttctatgag actgaagccc   1200

ggaaagtttt ttgtgaggtg tacaaggagc gtctctttgg gaagaagtac gtctggttcc   1260

tcattgggtg gtatgctgac aattggttca agatctacga cccttctatc aactgcacag   1320

tggatgagat gactgaggcg gtggagggcc acatcacaac tgagattgtc atgctgaatc   1380

ctgccaatac ccgcagcatt tccaacatga catcccagga atttgtggag aaactaacca   1440

agcgactgaa aagacaccct gaggagacag gaggcttcca ggaggcaccg ctggcctatg   1500

atgccatctg ggccttggca ctggccctga acaagacatc tggaggaggc ggccgttctg   1560

gtgtgcgcct ggaggacttc aactacaaca accagaccat taccgaccaa atctaccggg   1620

caatgaactc ttcgtccttt gagggtgtct ctggccatgt ggtgtttgat gccagcggct   1680

ctcggatggc atggacgctt atcgagcagc ttcagggtgg cagctacaag aagattggct   1740

actatgacag caccaaggat gatctttcct ggtccaaaac agataaatgg attggagggt   1800

cccccccagc tgaccagacc ctggtcatca agacattccg cttcctgtca cagaaactct   1860

ttatctccgt ctcagttctc tccagcctgg gcattgtcct agctgttgtc tgtctgtcct   1920

ttaacatcta caactcacat gtccgttata tccagaactc acagcccaac ctgaacaacc   1980

tgactgctgt gggctgctca ctggctttag ctgctgtctt ccccctgggg ctcgatggtt   2040

accacattgg gaggaaccag tttcctttcg tctgccaggc ccgcctctgg ctcctgggcc   2100

tgggctttag tctgggctac ggttccatgt tcaccaagat ttggtgggtc cacacggtct   2160

tcacaaagaa ggaagaaaag aaggagtgga ggaagactct ggaaccctgg aagctgtatg   2220

ccacagtggg cctgctggtg ggcatggatg tcctcactct cgccatctgg cagatcgtgg   2280

accctctgca ccggaccatt gagacatttg ccaaggagga acctaaggaa gatattgacg   2340

tctctattct gccccagctg gagcattgca gctccaggaa gatgaataca tggcttggca   2400

ttttctatgg ttacaagggg ctgctgctgc tgctgggaat cttccttgct tatgagacca   2460

agagtgtgtc cactgagaag atcaatgatc accgggctgt gggcatggct atctacaatg   2520

tggcagtcct gtgcctcatc actgctcctg tcaccatgat tctgtccagc cagcaggatg   2580

cagcctttgc ctttgcctct cttgccatag ttttctcctc ctatatcact cttgttgtgc   2640

tctttgtgcc caagatgcgc aggctgatca cccgagggga atggcagtcg gaggcgcagg   2700

acaccatgaa gacagggtca tcgaccaaca acaacgagga ggagaagtcc cggctgttgg   2760

agaaggagaa ccgtgaactg gaaaagatca ttgctgagaa agaggagcgt gtctctgaac   2820

tgcgccatca actccagtct cggcagcagc tccgctcccg gcgccaccca ccgacacccc   2880

cagaaccctc tgggggcctg cccaggggac cccctgagcc ccccgaccgg cttagctgtg   2940

atgggagtcg agtgcatttg ctttataagt gagggtgcat gtccgttccg aggaatggga   3000

tttaatgacc tttgatgcca acccatatga cagcgtgaaa aaaatcaaag aacatgtccg   3060

gtctaagacc aaggttcctg tgcaggacca ggttcttttg ctgggctcca agatcttaaa   3120

gccacggaga agcctctcat cttatggcat tgacaaagag aagaccatcc accttaccct   3180

gaaagtggtg aagcccagtg atgaggagct gcccttgttt cttgtggagt caggtgatga   3240

ggcaaagagg cacctcctcc aggtgcgaag gtccagctca gtggcacaag tgaaagcaat   3300

gatcgagact aagacgggta taatccctga gacccagatt gtgacttgca atggaaagag   3360

actggaagat gggaagatga tggcagatta cggcatcaga aagggcaact tactcttcct   3420

ggcatgttat tgtattggag ggtgaccacc ctgggcatgg ggtgttggca ggggtcaaaa   3480

agcttatttc ttttaatctc ttactcaacg aacacatctt ctgatgattt cccaaaatta   3540

atgagaatga gatgagtaga gtaagatttg ggtgggatgg gtaggatgaa gtatattgcc   3600

caactctatg tttctttgat tctaacacaa ttaattaagt gacatgattt ttactaatgt   3660

attactgaga ctagtaaata aatttttaag gcaaaataga gcattcaaag cc           3712


<210>  3163
<211>  844
<212>  PRT
<213>  Homo sapiens

<400>  3163

Met Gly Pro Gly Ala Pro Phe Ala Arg Val Gly Trp Pro Leu Pro Leu 
1               5                   10                  15


Leu Val Val Met Ala Ala Gly Val Ala Pro Val Trp Ala Ser His Ser 
            20                  25                  30


Pro His Leu Pro Arg Pro His Ser Arg Val Pro Pro His Pro Ser Ser 
        35                  40                  45


Glu Arg Arg Ala Val Tyr Ile Gly Ala Leu Phe Pro Met Ser Gly Gly 
    50                  55                  60


Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val Glu Met Ala Leu Glu 
65                  70                  75                  80


Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp Tyr Glu Leu Lys Leu 
                85                  90                  95


Ile His His Asp Ser Lys Cys Asp Pro Gly Gln Ala Thr Lys Tyr Leu 
            100                 105                 110


Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile Ile Leu Met Pro Gly 
        115                 120                 125


Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala Ala Arg Met Trp Asn 
    130                 135                 140


Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro Ala Leu Ser Asn Arg 
145                 150                 155                 160


Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro Ser Ala Thr Leu His 
                165                 170                 175


Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp Gly Trp Lys Lys Ile 
            180                 185                 190


Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr Ser Thr Leu Asp Asp 
        195                 200                 205


Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu Ile Thr Phe Arg Gln 
    210                 215                 220


Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys Asn Leu Lys Arg Gln 
225                 230                 235                 240


Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu Thr Glu Ala Arg Lys 
                245                 250                 255


Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe Gly Lys Lys Tyr Val 
            260                 265                 270


Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp Phe Lys Ile Tyr Asp 
        275                 280                 285


Pro Ser Ile Asn Cys Thr Val Asp Glu Met Thr Glu Ala Val Glu Gly 
    290                 295                 300


His Ile Thr Thr Glu Ile Val Met Leu Asn Pro Ala Asn Thr Arg Ser 
305                 310                 315                 320


Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu Lys Leu Thr Lys Arg 
                325                 330                 335


Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe Gln Glu Ala Pro Leu 
            340                 345                 350


Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala Leu Asn Lys Thr Ser 
        355                 360                 365


Gly Gly Gly Gly Arg Ser Gly Val Arg Leu Glu Asp Phe Asn Tyr Asn 
    370                 375                 380


Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala Met Asn Ser Ser Ser 
385                 390                 395                 400


Phe Glu Gly Val Ser Gly His Val Val Phe Asp Ala Ser Gly Ser Arg 
                405                 410                 415


Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly Gly Ser Tyr Lys Lys 
            420                 425                 430


Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu Ser Trp Ser Lys Thr 
        435                 440                 445


Asp Lys Trp Ile Gly Gly Ser Pro Pro Ala Asp Gln Thr Leu Val Ile 
    450                 455                 460


Lys Thr Phe Arg Phe Leu Ser Gln Lys Leu Phe Ile Ser Val Ser Val 
465                 470                 475                 480


Leu Ser Ser Leu Gly Ile Val Leu Ala Val Val Cys Leu Ser Phe Asn 
                485                 490                 495


Ile Tyr Asn Ser His Val Arg Tyr Ile Gln Asn Ser Gln Pro Asn Leu 
            500                 505                 510


Asn Asn Leu Thr Ala Val Gly Cys Ser Leu Ala Leu Ala Ala Val Phe 
        515                 520                 525


Pro Leu Gly Leu Asp Gly Tyr His Ile Gly Arg Asn Gln Phe Pro Phe 
    530                 535                 540


Val Cys Gln Ala Arg Leu Trp Leu Leu Gly Leu Gly Phe Ser Leu Gly 
545                 550                 555                 560


Tyr Gly Ser Met Phe Thr Lys Ile Trp Trp Val His Thr Val Phe Thr 
                565                 570                 575


Lys Lys Glu Glu Lys Lys Glu Trp Arg Lys Thr Leu Glu Pro Trp Lys 
            580                 585                 590


Leu Tyr Ala Thr Val Gly Leu Leu Val Gly Met Asp Val Leu Thr Leu 
        595                 600                 605


Ala Ile Trp Gln Ile Val Asp Pro Leu His Arg Thr Ile Glu Thr Phe 
    610                 615                 620


Ala Lys Glu Glu Pro Lys Glu Asp Ile Asp Val Ser Ile Leu Pro Gln 
625                 630                 635                 640


Leu Glu His Cys Ser Ser Arg Lys Met Asn Thr Trp Leu Gly Ile Phe 
                645                 650                 655


Tyr Gly Tyr Lys Gly Leu Leu Leu Leu Leu Gly Ile Phe Leu Ala Tyr 
            660                 665                 670


Glu Thr Lys Ser Val Ser Thr Glu Lys Ile Asn Asp His Arg Ala Val 
        675                 680                 685


Gly Met Ala Ile Tyr Asn Val Ala Val Leu Cys Leu Ile Thr Ala Pro 
    690                 695                 700


Val Thr Met Ile Leu Ser Ser Gln Gln Asp Ala Ala Phe Ala Phe Ala 
705                 710                 715                 720


Ser Leu Ala Ile Val Phe Ser Ser Tyr Ile Thr Leu Val Val Leu Phe 
                725                 730                 735


Val Pro Lys Met Arg Arg Leu Ile Thr Arg Gly Glu Trp Gln Ser Glu 
            740                 745                 750


Ala Gln Asp Thr Met Lys Thr Gly Ser Ser Thr Asn Asn Asn Glu Glu 
        755                 760                 765


Glu Lys Ser Arg Leu Leu Glu Lys Glu Asn Arg Glu Leu Glu Lys Ile 
    770                 775                 780


Ile Ala Glu Lys Glu Glu Arg Val Ser Glu Leu Arg His Gln Leu Gln 
785                 790                 795                 800


Ser Arg Gln Gln Leu Arg Ser Arg Arg His Pro Pro Thr Pro Pro Glu 
                805                 810                 815


Pro Ser Gly Gly Leu Pro Arg Gly Pro Pro Glu Pro Pro Asp Arg Leu 
            820                 825                 830


Ser Cys Asp Gly Ser Arg Val His Leu Leu Tyr Lys 
        835                 840


<210>  3164
<211>  1465
<212>  DNA
<213>  Homo sapiens

<400>  3164
caacttatca gaaaattcat tcaatatacc ttacgagatc atccaataga taagagacaa     60

ctctagaaca gcattcagaa catagtggca ctcaataaat ttcccctgaa tgaatgaatt    120

aatgaattag tgcatatttt aatcagcctc ctttgccctc acccaggaag tcagaggcac    180

cagtgtgagt atccatctgc tgtccagtac attcatggat tcctcactct cactagacaa    240

tgtttgacca ggaagaacag ggaatgagaa ggagctgctg gatggtgatg agccttggaa    300

agggaggctg ggcgagcaga gacagaagag aaacacctac ctgctgtgac ctcacaaaca    360

cccaggctga gttttgataa gacaggttga atcacactgg agtgacagcc tcatccctcc    420

aggtacaaac aagaacaggc catggttaac caaagctcca caccgggctt cctccttctg    480

ggcttctctg aacacccagg gctggaaagg actctcttcg tggttgtcct cacttcctac    540

ctcctaaccc tagtgggcaa cacactcatc atcctgctgt ctgcgctgga ccccaagctc    600

cactctccaa tgtacttttt cctctccaac ctctccttct tggacctctg tttcaccacg    660

agttgtgttc cccaaatgct ggtcaacctc tggggcccaa agaagaccat cagcttcctg    720

gactgctctg tccagatctt catcttcctg tccctgggga caactgagtg catcctcttg    780

acagtgatgg cttttgatcg ctacgtggct gtctgccagc ccctccacta tgccaccatc    840

atccaccccc gcctgtgctg gcagctggca tctgtggcct gggtcattgg gctagtggag    900

tcagtggtcc agacaccatc caccctgcac ctgcccttct gccccgatcg gcaggtggat    960

gattttgtct gtgaggtccc agctctaatt cgactctcct gtgaagacac ctcctacaat   1020

gagatccagg tggctgttgc cagtgtcttc atcttggttg tgcctctcag cctcatcctt   1080

gtctcttacg gagccattac ctgggcagtg ctgaggatta actctgcaaa agggcggagg   1140

aaagcttttg ggacctgctc ctcccatctc actgtggtca ccctcttcta cagctcagtc   1200

attgctgtct acctccagcc caaaaatccc tatgcccaag agaggggcaa gttctttggt   1260

ctcttctatg cagtgggcac tccttcactt aaccctctca tatacaccct gaggaacaag   1320

gaggtaacca gggcattcag gagattgctg gggaaggaaa tggggctcac acaaagctga   1380

gggagagctg cttaatgtgc tttaaaagag aggagattct atgtgctttt atcagaaagt   1440

ttgagttccc tgcccctctg ccttc                                         1465


<210>  3165
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  3165

Met Val Asn Gln Ser Ser Thr Pro Gly Phe Leu Leu Leu Gly Phe Ser 
1               5                   10                  15


Glu His Pro Gly Leu Glu Arg Thr Leu Phe Val Val Val Leu Thr Ser 
            20                  25                  30


Tyr Leu Leu Thr Leu Val Gly Asn Thr Leu Ile Ile Leu Leu Ser Ala 
        35                  40                  45


Leu Asp Pro Lys Leu His Ser Pro Met Tyr Phe Phe Leu Ser Asn Leu 
    50                  55                  60


Ser Phe Leu Asp Leu Cys Phe Thr Thr Ser Cys Val Pro Gln Met Leu 
65                  70                  75                  80


Val Asn Leu Trp Gly Pro Lys Lys Thr Ile Ser Phe Leu Asp Cys Ser 
                85                  90                  95


Val Gln Ile Phe Ile Phe Leu Ser Leu Gly Thr Thr Glu Cys Ile Leu 
            100                 105                 110


Leu Thr Val Met Ala Phe Asp Arg Tyr Val Ala Val Cys Gln Pro Leu 
        115                 120                 125


His Tyr Ala Thr Ile Ile His Pro Arg Leu Cys Trp Gln Leu Ala Ser 
    130                 135                 140


Val Ala Trp Val Ile Gly Leu Val Glu Ser Val Val Gln Thr Pro Ser 
145                 150                 155                 160


Thr Leu His Leu Pro Phe Cys Pro Asp Arg Gln Val Asp Asp Phe Val 
                165                 170                 175


Cys Glu Val Pro Ala Leu Ile Arg Leu Ser Cys Glu Asp Thr Ser Tyr 
            180                 185                 190


Asn Glu Ile Gln Val Ala Val Ala Ser Val Phe Ile Leu Val Val Pro 
        195                 200                 205


Leu Ser Leu Ile Leu Val Ser Tyr Gly Ala Ile Thr Trp Ala Val Leu 
    210                 215                 220


Arg Ile Asn Ser Ala Lys Gly Arg Arg Lys Ala Phe Gly Thr Cys Ser 
225                 230                 235                 240


Ser His Leu Thr Val Val Thr Leu Phe Tyr Ser Ser Val Ile Ala Val 
                245                 250                 255


Tyr Leu Gln Pro Lys Asn Pro Tyr Ala Gln Glu Arg Gly Lys Phe Phe 
            260                 265                 270


Gly Leu Phe Tyr Ala Val Gly Thr Pro Ser Leu Asn Pro Leu Ile Tyr 
        275                 280                 285


Thr Leu Arg Asn Lys Glu Val Thr Arg Ala Phe Arg Arg Leu Leu Gly 
    290                 295                 300


Lys Glu Met Gly Leu Thr Gln Ser 
305                 310


<210>  3166
<211>  1923
<212>  DNA
<213>  Homo sapiens

<400>  3166
tttctcaatc tatatttgag gatgatcctg aatttggatc cttttcaaag ggaaagttca     60

ccaggaaact gtctgcatag actccctccc atgggaagta aactctggat cttgtctgag    120

cctgcagacc tgagactccc tcaatgtgtc tttccctcta ggtcctgtgc ctcatcactg    180

ctcctgtcac catgattctg tccagccagc aggatgcagc ctttgccttt gcctctcttg    240

ccatagtttt ctcctcctat atcactcttg ttgtgctctt tgtgcccaag atgcgcaggc    300

tgatcacccg aggggaatgg cagtcggagg cgcaggacac catgaagaca gggtcatcga    360

ccaacaacaa cgaggaggag aagtcccggc tgttggagaa ggagaaccgt gaactggaaa    420

agatcattgc tgagaaagag gagcgtgtct ctgaactgcg ccatcaactc cagtctcggc    480

agcagctccg ctcccggcgc cacccaccga cacccccaga accctctggg ggcctgccca    540

ggggaccccc tgagcccccc gaccggctta gctgtgatgg gagtcgagtg catttgcttt    600

ataagtgagg gtagggtgag ggaggacagg ccagtagggg gagggaaagg gagaggggaa    660

gggcagggga ctcaggaagc agggggtccc catccccagc tgggaagaac atgctatcca    720

atctcatctc ttgtaaatac atgtccccct gtgagttctg ggctgatttg ggtctctcat    780

acctctggga aacagacctt tttctctctt actgcttcat gtaattttgt atcacctctt    840

cacaatttag ttcgtacctg gcttgaagct gctcactgct cacacgctgc ctcctcagca    900

gcctcactgc atctttctct tcccatgcaa caccctcttc tagttaccac ggcaacccct    960

gcagctcctc tgcctttgtg ctctgttcct gtccagcagg ggtctcccaa caagtgctct   1020

ttccacccca aaggggcctc tccttttctc cactgtcata atctctttcc atcttacttg   1080

cccttctata ctttctcaca tgtggctccc cctgaatttt gcttcctttg ggagctcatt   1140

cttttcgcca aggctcacat gctccttgcc tctgctctgt gcactcacgc tcagcacaca   1200

tgcatcctcc cctctcctgc gtgtgcccac tgaacatgct catgtgtaca cacgcttttc   1260

ccgtatgctt tcttcatgtt cagtcacatg tgctctcggg tgccctgcat tcacagctac   1320

gtgtgcccct ctcatggtca tgggtctgcc cttgagcgtg tttgggtagg catgtgcaat   1380

ttgtctagca tgctgagtca tgtctttcct atttgcacac gtccatgttt atccatgtac   1440

tttccctgtg taccctccat gtaccttgtg tactttcttc ccttaaatca tggtattctt   1500

ctgacagagc catatgtacc ctaccctgca cattgttatg cacttttccc caattcatgt   1560

ttggtggggc catccacacc ctctccttgt cacagaatct ccatttctgc tcagattccc   1620

cccatctcca ttgcattcat gtactaccct cagtctacac tcacaatcat cttctcccaa   1680

gactgctccc ttttgttttg tgtttttttg aggggaatta aggaaaaata agtgggggca   1740

ggtttggaga gctgcttcca gtggatagtt gatgagaatc ctgaccaaag gaaggcaccc   1800

ttgactgttg ggatagacag atggacctat ggggtgggag gtggtgtccc tttcacactg   1860

tggtgtctct tggggaagga tctccccgaa tctcaataaa ccagtgaaca gtgtgactcg   1920

gca                                                                 1923


<210>  3167
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  3167

Met Ile Leu Ser Ser Gln Gln Asp Ala Ala Phe Ala Phe Ala Ser Leu 
1               5                   10                  15


Ala Ile Val Phe Ser Ser Tyr Ile Thr Leu Val Val Leu Phe Val Pro 
            20                  25                  30


Lys Met Arg Arg Leu Ile Thr Arg Gly Glu Trp Gln Ser Glu Ala Gln 
        35                  40                  45


Asp Thr Met Lys Thr Gly Ser Ser Thr Asn Asn Asn Glu Glu Glu Lys 
    50                  55                  60


Ser Arg Leu Leu Glu Lys Glu Asn Arg Glu Leu Glu Lys Ile Ile Ala 
65                  70                  75                  80


Glu Lys Glu Glu Arg Val Ser Glu Leu Arg His Gln Leu Gln Ser Arg 
                85                  90                  95


Gln Gln Leu Arg Ser Arg Arg His Pro Pro Thr Pro Pro Glu Pro Ser 
            100                 105                 110


Gly Gly Leu Pro Arg Gly Pro Pro Glu Pro Pro Asp Arg Leu Ser Cys 
        115                 120                 125


Asp Gly Ser Arg Val His Leu Leu Tyr Lys 
    130                 135


<210>  3168
<211>  4287
<212>  DNA
<213>  Homo sapiens

<400>  3168
cgttcctttc ctcctcgagg ttgcatcccc cctcccctcc ccgcccctcc gactgtcgct     60

cccacctcgg cgctcgcttc cctccccgcc cccttcctgc ctccccagct cccgcccgcc    120

cccccacccc ccgctgccgc gcgccgcccg tgacgtcaga gccccctccc agccccacat    180

ctccctcctg ctcctcctcc tcccctccgt cggtcagtca gtccgcgagg agagtccgcg    240

gtggcggcga cggtggcgag agccgcgggg gccgtaggaa gccaaccttc cctgcttctc    300

cggggccctc gccccctcct ccccacaaaa tcagggatgg aggcgcctcc ccggcaccct    360

cttagcagcc ctccccagga aaagtgtccc ccctgagctc ctaacgctcc ccaacagcta    420

cccctgcccc ccacgccatg gggcccgggg ccccttttgc ccgggtgggg tggccactgc    480

cgcttctggt tgtgatggcg gcaggggtgg ctccggtgtg ggcctcccac tccccccatc    540

tcccgcggcc tcactcgcgg gtccccccgc acccctcctc agaacggcgc gcagtgtaca    600

tcggggcact gtttcccatg agcgggggct ggccaggggg ccaggcctgc cagcccgcgg    660

tggagatggc gctggaggac gtgaatagcc gcagggacat cctgccggac tatgagctca    720

agctcatcca ccacgacagc aagtgtgatc caggccaagc caccaagtac ctatatgagc    780

tgctctacaa cgaccctatc aagatcatcc ttatgcctgg ctgcagctct gtctccacgc    840

tggtggctga ggctgctagg atgtggaacc tcattgtgct ttcctatggc tccagctcac    900

cagccctgtc aaaccggcag cgtttcccca ctttcttccg aacgcaccca tcagccacac    960

tccacaaccc tacccgcgtg aaactctttg aaaagtgggg ctggaagaag attgctacca   1020

tccagcagac cactgaggtc ttcacttcga ctctggacga cctggaggaa cgagtgaagg   1080

aggctggaat tgagattact ttccgccaga gtttcttctc agatccagct gtgcccgtca   1140

aaaacctgaa gcgccaggat gcccgaatca tcgtgggact tttctatgag actgaagccc   1200

ggaaagtttt ttgtgaggtg tacaaggagc gtctctttgg gaagaagtac gtctggttcc   1260

tcattgggtg gtatgctgac aattggttca agatctacga cccttctatc aactgcacag   1320

tggatgagat gactgaggcg gtggagggcc acatcacaac tgagattgtc atgctgaatc   1380

ctgccaatac ccgcagcatt tccaacatga catcccagga atttgtggag aaactaacca   1440

agcgactgaa aagacaccct gaggagacag gaggcttcca ggaggcaccg ctggcctatg   1500

atgccatctg ggccttggca ctggccctga acaagacatc tggaggaggc ggccgttctg   1560

gtgtgcgcct ggaggacttc aactacaaca accagaccat taccgaccaa atctaccggg   1620

caatgaactc ttcgtccttt gagggtgtct ctggccatgt ggtgtttgat gccagcggct   1680

ctcggatggc atggacgctt atcgagcagc ttcagggtgg cagctacaag aagattggct   1740

actatgacag caccaaggat gatctttcct ggtccaaaac agataaatgg attggagggt   1800

cccccccagc tgaccagacc ctggtcatca agacattccg cttcctgtca cagaaactct   1860

ttatctccgt ctcagttctc tccagcctgg gcattgtcct agctgttgtc tgtctgtcct   1920

ttaacatcta caactcacat gtccgttata tccagaactc acagcccaac ctgaacaacc   1980

tgactgctgt gggctgctca ctggctttag ctgctgtctt ccccctgggg ctcgatggtt   2040

accacattgg gaggaaccag tttcctttcg tctgccaggc ccgcctctgg ctcctgggcc   2100

tgggctttag tctgggctac ggttccatgt tcaccaagat ttggtgggtc cacacggtct   2160

tcacaaagaa ggaagaaaag aaggagtgga ggaagactct ggaaccctgg aagctgtatg   2220

ccacagtggg cctgctggtg ggcatggatg tcctcactct cgccatctgg cagatcgtgg   2280

accctctgca ccggaccatt gagacatttg ccaaggagga acctaaggaa gatattgacg   2340

tctctattct gccccagctg gagcattgca gctccaggaa gatgaataca tggcttggca   2400

ttttctatgg ttacaagggg ctgctgctgc tgctgggaat cttccttgct tatgagacca   2460

agagtgtgtc cactgagaag atcaatgatc accgggctgt gggcatggct atctacaatg   2520

tggcagtcct gtgcctcatc actgctcctg tcaccatgat tctgtccagc cagcaggatg   2580

cagcctttgc ctttgcctct cttgccatag ttttctcctc ctatatcact cttgttgtgc   2640

tctttgtgcc caagatgcgc aggctgatca cccgagggga atggcagtcg gaggcgcagg   2700

acaccatgaa gacagggtca tcgaccaaca acaacgagga ggagaagtcc cggctgttgg   2760

agaaggagaa ccgtgaactg gaaaagatca ttgctgagaa agaggagcgt gtctctgaac   2820

tgcgccatca actccagtct cggcagcagc tccgctcccg gcgccaccca ccgacacccc   2880

cagaaccctc tgggggcctg cccaggggac cccctgagcc ccccgaccgg cttagctgtg   2940

atgggagtcg agtgcatttg ctttataagt gagggtaggg tgagggagga caggccagta   3000

gggggaggga aagggagagg ggaagggcag gggactcagg aagcaggggg tccccatccc   3060

cagctgggaa gaacatgcta tccaatctca tctcttgtaa atacatgtcc ccctgtgagt   3120

tctgggctga tttgggtctc tcatacctct gggaaacaga cctttttctc tcttactgct   3180

tcatgtaatt ttgtatcacc tcttcacaat ttagttcgta cctggcttga agctgctcac   3240

tgctcacacg ctgcctcctc agcagcctca ctgcatcttt ctcttcccat gcaacaccct   3300

cttctagtta ccacggcaac ccctgcagct cctctgcctt tgtgctctgt tcctgtccag   3360

caggggtctc ccaacaagtg ctctttccac cccaaagggg cctctccttt tctccactgt   3420

cataatctct ttccatctta cttgcccttc tatactttct cacatgtggc tccccctgaa   3480

ttttgcttcc tttgggagct cattcttttc gccaaggctc acatgctcct tgcctctgct   3540

ctgtgcactc acgctcagca cacatgcatc ctcccctctc ctgcgtgtgc ccactgaaca   3600

tgctcatgtg tacacacgct tttcccgtat gctttcttca tgttcagtca catgtgctct   3660

cgggtgccct gcattcacag ctacgtgtgc ccctctcatg gtcatgggtc tgcccttgag   3720

cgtgtttggg taggcatgtg caatttgtct agcatgctga gtcatgtctt tcctatttgc   3780

acacgtccat gtttatccat gtactttccc tgtgtaccct ccatgtacct tgtgtacttt   3840

cttcccttaa atcatggtat tcttctgaca gagccatatg taccctaccc tgcacattgt   3900

tatgcacttt tccccaattc atgtttggtg gggccatcca caccctctcc ttgtcacaga   3960

atctccattt ctgctcagat tccccccatc tccattgcat tcatgtacta ccctcagtct   4020

acactcacaa tcatcttctc ccaagactgc tcccttttgt tttgtgtttt tttgagggga   4080

attaaggaaa aataagtggg ggcaggtttg gagagctgct tccagtggat agttgatgag   4140

aatcctgacc aaaggaaggc acccttgact gttgggatag acagatggac ctatggggtg   4200

ggaggtggtg tccctttcac actgtggtgt ctcttgggga aggatctccc cgaatctcaa   4260

taaaccagtg aacagtgtga ctcggca                                       4287


<210>  3169
<211>  844
<212>  PRT
<213>  Homo sapiens

<400>  3169

Met Gly Pro Gly Ala Pro Phe Ala Arg Val Gly Trp Pro Leu Pro Leu 
1               5                   10                  15


Leu Val Val Met Ala Ala Gly Val Ala Pro Val Trp Ala Ser His Ser 
            20                  25                  30


Pro His Leu Pro Arg Pro His Ser Arg Val Pro Pro His Pro Ser Ser 
        35                  40                  45


Glu Arg Arg Ala Val Tyr Ile Gly Ala Leu Phe Pro Met Ser Gly Gly 
    50                  55                  60


Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val Glu Met Ala Leu Glu 
65                  70                  75                  80


Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp Tyr Glu Leu Lys Leu 
                85                  90                  95


Ile His His Asp Ser Lys Cys Asp Pro Gly Gln Ala Thr Lys Tyr Leu 
            100                 105                 110


Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile Ile Leu Met Pro Gly 
        115                 120                 125


Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala Ala Arg Met Trp Asn 
    130                 135                 140


Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro Ala Leu Ser Asn Arg 
145                 150                 155                 160


Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro Ser Ala Thr Leu His 
                165                 170                 175


Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp Gly Trp Lys Lys Ile 
            180                 185                 190


Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr Ser Thr Leu Asp Asp 
        195                 200                 205


Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu Ile Thr Phe Arg Gln 
    210                 215                 220


Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys Asn Leu Lys Arg Gln 
225                 230                 235                 240


Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu Thr Glu Ala Arg Lys 
                245                 250                 255


Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe Gly Lys Lys Tyr Val 
            260                 265                 270


Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp Phe Lys Ile Tyr Asp 
        275                 280                 285


Pro Ser Ile Asn Cys Thr Val Asp Glu Met Thr Glu Ala Val Glu Gly 
    290                 295                 300


His Ile Thr Thr Glu Ile Val Met Leu Asn Pro Ala Asn Thr Arg Ser 
305                 310                 315                 320


Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu Lys Leu Thr Lys Arg 
                325                 330                 335


Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe Gln Glu Ala Pro Leu 
            340                 345                 350


Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala Leu Asn Lys Thr Ser 
        355                 360                 365


Gly Gly Gly Gly Arg Ser Gly Val Arg Leu Glu Asp Phe Asn Tyr Asn 
    370                 375                 380


Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala Met Asn Ser Ser Ser 
385                 390                 395                 400


Phe Glu Gly Val Ser Gly His Val Val Phe Asp Ala Ser Gly Ser Arg 
                405                 410                 415


Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly Gly Ser Tyr Lys Lys 
            420                 425                 430


Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu Ser Trp Ser Lys Thr 
        435                 440                 445


Asp Lys Trp Ile Gly Gly Ser Pro Pro Ala Asp Gln Thr Leu Val Ile 
    450                 455                 460


Lys Thr Phe Arg Phe Leu Ser Gln Lys Leu Phe Ile Ser Val Ser Val 
465                 470                 475                 480


Leu Ser Ser Leu Gly Ile Val Leu Ala Val Val Cys Leu Ser Phe Asn 
                485                 490                 495


Ile Tyr Asn Ser His Val Arg Tyr Ile Gln Asn Ser Gln Pro Asn Leu 
            500                 505                 510


Asn Asn Leu Thr Ala Val Gly Cys Ser Leu Ala Leu Ala Ala Val Phe 
        515                 520                 525


Pro Leu Gly Leu Asp Gly Tyr His Ile Gly Arg Asn Gln Phe Pro Phe 
    530                 535                 540


Val Cys Gln Ala Arg Leu Trp Leu Leu Gly Leu Gly Phe Ser Leu Gly 
545                 550                 555                 560


Tyr Gly Ser Met Phe Thr Lys Ile Trp Trp Val His Thr Val Phe Thr 
                565                 570                 575


Lys Lys Glu Glu Lys Lys Glu Trp Arg Lys Thr Leu Glu Pro Trp Lys 
            580                 585                 590


Leu Tyr Ala Thr Val Gly Leu Leu Val Gly Met Asp Val Leu Thr Leu 
        595                 600                 605


Ala Ile Trp Gln Ile Val Asp Pro Leu His Arg Thr Ile Glu Thr Phe 
    610                 615                 620


Ala Lys Glu Glu Pro Lys Glu Asp Ile Asp Val Ser Ile Leu Pro Gln 
625                 630                 635                 640


Leu Glu His Cys Ser Ser Arg Lys Met Asn Thr Trp Leu Gly Ile Phe 
                645                 650                 655


Tyr Gly Tyr Lys Gly Leu Leu Leu Leu Leu Gly Ile Phe Leu Ala Tyr 
            660                 665                 670


Glu Thr Lys Ser Val Ser Thr Glu Lys Ile Asn Asp His Arg Ala Val 
        675                 680                 685


Gly Met Ala Ile Tyr Asn Val Ala Val Leu Cys Leu Ile Thr Ala Pro 
    690                 695                 700


Val Thr Met Ile Leu Ser Ser Gln Gln Asp Ala Ala Phe Ala Phe Ala 
705                 710                 715                 720


Ser Leu Ala Ile Val Phe Ser Ser Tyr Ile Thr Leu Val Val Leu Phe 
                725                 730                 735


Val Pro Lys Met Arg Arg Leu Ile Thr Arg Gly Glu Trp Gln Ser Glu 
            740                 745                 750


Ala Gln Asp Thr Met Lys Thr Gly Ser Ser Thr Asn Asn Asn Glu Glu 
        755                 760                 765


Glu Lys Ser Arg Leu Leu Glu Lys Glu Asn Arg Glu Leu Glu Lys Ile 
    770                 775                 780


Ile Ala Glu Lys Glu Glu Arg Val Ser Glu Leu Arg His Gln Leu Gln 
785                 790                 795                 800


Ser Arg Gln Gln Leu Arg Ser Arg Arg His Pro Pro Thr Pro Pro Glu 
                805                 810                 815


Pro Ser Gly Gly Leu Pro Arg Gly Pro Pro Glu Pro Pro Asp Arg Leu 
            820                 825                 830


Ser Cys Asp Gly Ser Arg Val His Leu Leu Tyr Lys 
        835                 840


<210>  3170
<211>  4386
<212>  DNA
<213>  Homo sapiens

<400>  3170
ccctctcttc cccccgccct gccttccctt gcaccctcct tcttccctcc gcccgggagc     60

tctccctggt ccccggcgcc gcctccttcc ctcccggctc cccgctcccc gctcccgtgg    120

ctgccgccgc cccggggaag aagagacagg ggtggggttt gggggaagcg agagaggagg    180

ggagagaccc tggccaggct ggagcctgga ttcgagggga ggagggacgg gaggaggaga    240

aaggtggagg agaagggagg ggggagcggg gaggagcggc cgggcctggg gccttgaggc    300

ccggggagag ccggggagcc gggcccgcgc gccgagatgt tgctgctgct gctactggcg    360

ccactcttcc tccgcccccc gggcgcgggc ggggcgcaga cccccaacgc cacctcagaa    420

ggttgccaga tcatacaccc gccctgggaa gggggcatca ggtaccgggg cctgactcgg    480

gaccaggtga aggctatcaa cttcctgcca gtggactatg agattgagta tgtgtgccgg    540

ggggagcgcg aggtggtggg gcccaaggtc cgcaagtgcc tggccaacgg ctcctggaca    600

gatatggaca cacccagccg ctgtgtccga atctgctcca agtcttattt gaccctggaa    660

aatgggaagg ttttcctgac gggtggggac ctcccagctc tggacggagc ccgggtggat    720

ttccggtgtg accccgactt ccatctggtg ggcagctccc ggagcatctg tagtcagggc    780

cagtggagca cccccaagcc ccactgccag gtgaatcgaa cgccacactc agaacggcgc    840

gcagtgtaca tcggggcact gtttcccatg agcgggggct ggccaggggg ccaggcctgc    900

cagcccgcgg tggagatggc gctggaggac gtgaatagcc gcagggacat cctgccggac    960

tatgagctca agctcatcca ccacgacagc aagtgtgatc caggccaagc caccaagtac   1020

ctatatgagc tgctctacaa cgaccctatc aagatcatcc ttatgcctgg ctgcagctct   1080

gtctccacgc tggtggctga ggctgctagg atgtggaacc tcattgtgct ttcctatggc   1140

tccagctcac cagccctgtc aaaccggcag cgtttcccca ctttcttccg aacgcaccca   1200

tcagccacac tccacaaccc tacccgcgtg aaactctttg aaaagtgggg ctggaagaag   1260

attgctacca tccagcagac cactgaggtc ttcacttcga ctctggacga cctggaggaa   1320

cgagtgaagg aggctggaat tgagattact ttccgccaga gtttcttctc agatccagct   1380

gtgcccgtca aaaacctgaa gcgccaggat gcccgaatca tcgtgggact tttctatgag   1440

actgaagccc ggaaagtttt ttgtgaggtg tacaaggagc gtctctttgg gaagaagtac   1500

gtctggttcc tcattgggtg gtatgctgac aattggttca agatctacga cccttctatc   1560

aactgcacag tggatgagat gactgaggcg gtggagggcc acatcacaac tgagattgtc   1620

atgctgaatc ctgccaatac ccgcagcatt tccaacatga catcccagga atttgtggag   1680

aaactaacca agcgactgaa aagacaccct gaggagacag gaggcttcca ggaggcaccg   1740

ctggcctatg atgccatctg ggccttggca ctggccctga acaagacatc tggaggaggc   1800

ggccgttctg gtgtgcgcct ggaggacttc aactacaaca accagaccat taccgaccaa   1860

atctaccggg caatgaactc ttcgtccttt gagggtgtct ctggccatgt ggtgtttgat   1920

gccagcggct ctcggatggc atggacgctt atcgagcagc ttcagggtgg cagctacaag   1980

aagattggct actatgacag caccaaggat gatctttcct ggtccaaaac agataaatgg   2040

attgttatat ccagaactca cagcccaacc tgaacaacct gactgctgtg ggctgctcac   2100

tggctttagc tgctgtcttc cccctggggc tcgatggtta ccacattggg aggaaccagt   2160

ttcctttcgt ctgccaggcc cgcctctggc tcctgggcct gggctttagt ctgggctacg   2220

gttccatgtt caccaagatt tggtgggtcc acacggtctt cacaaagaag gaagaaaaga   2280

aggagtggag gaagactctg gaaccctgga agctgtatgc cacagtgggc ctgctggtgg   2340

gcatggatgt cctcactctc gccatctggc agatcgtgga ccctctgcac cggaccattg   2400

agacatttgc caaggaggaa cctaaggaag atattgacgt ctctattctg ccccagctgg   2460

agcattgcag ctccaggaag atgaatacat ggcttggcat tttctatggt tacaaggggc   2520

tgctgctgct gctgggaatc ttccttgctt atgagaccaa gagtgtgtcc actgagaaga   2580

tcaatgatca ccgggctgtg ggcatggcta tctacaatgt ggcagtcctg tgcctcatca   2640

ctgctcctgt caccatgatt ctgtccagcc agcaggatgc agcctttgcc tttgcctctc   2700

ttgccatagt tttctcctcc tatatcactc ttgttgtgct ctttgtgccc aagatgcgca   2760

ggctgatcac ccgaggggaa tggcagtcgg aggcgcagga caccatgaag acagggtcat   2820

cgaccaacaa caacgaggag gagaagtccc ggctgttgga gaaggagaac cgtgaactgg   2880

aaaagatcat tgctgagaaa gaggagcgtg tctctgaact gcgccatcaa ctccagtctc   2940

ggcagcagct ccgctcccgg cgccacccac cgacaccccc agaaccctct gggggcctgc   3000

ccaggggacc ccctgagccc cccgaccggc ttagctgtga tgggagtcga gtgcatttgc   3060

tttataagtg agggtagggt gagggaggac aggccagtag ggggagggaa agggagaggg   3120

gaagggcagg ggactcagga agcagggggt ccccatcccc agctgggaag aacatgctat   3180

ccaatctcat ctcttgtaaa tacatgtccc cctgtgagtt ctgggctgat ttgggtctct   3240

catacctctg ggaaacagac ctttttctct cttactgctt catgtaattt tgtatcacct   3300

cttcacaatt tagttcgtac ctggcttgaa gctgctcact gctcacacgc tgcctcctca   3360

gcagcctcac tgcatctttc tcttcccatg caacaccctc ttctagttac cacggcaacc   3420

cctgcagctc ctctgccttt gtgctctgtt cctgtccagc aggggtctcc caacaagtgc   3480

tctttccacc ccaaaggggc ctctcctttt ctccactgtc ataatctctt tccatcttac   3540

ttgcccttct atactttctc acatgtggct ccccctgaat tttgcttcct ttgggagctc   3600

attcttttcg ccaaggctca catgctcctt gcctctgctc tgtgcactca cgctcagcac   3660

acatgcatcc tcccctctcc tgcgtgtgcc cactgaacat gctcatgtgt acacacgctt   3720

ttcccgtatg ctttcttcat gttcagtcac atgtgctctc gggtgccctg cattcacagc   3780

tacgtgtgcc cctctcatgg tcatgggtct gcccttgagc gtgtttgggt aggcatgtgc   3840

aatttgtcta gcatgctgag tcatgtcttt cctatttgca cacgtccatg tttatccatg   3900

tactttccct gtgtaccctc catgtacctt gtgtactttc ttcccttaaa tcatggtatt   3960

cttctgacag agccatatgt accctaccct gcacattgtt atgcactttt ccccaattca   4020

tgtttggtgg ggccatccac accctctcct tgtcacagaa tctccatttc tgctcagatt   4080

ccccccatct ccattgcatt catgtactac cctcagtcta cactcacaat catcttctcc   4140

caagactgct cccttttgtt ttgtgttttt ttgaggggaa ttaaggaaaa ataagtgggg   4200

gcaggtttgg agagctgctt ccagtggata gttgatgaga atcctgacca aaggaaggca   4260

cccttgactg ttgggataga cagatggacc tatggggtgg gaggtggtgt ccctttcaca   4320

ctgtggtgtc tcttggggaa ggatctcccc gaatctcaat aaaccagtga acagtgtgac   4380

tcggca                                                              4386


<210>  3171
<211>  578
<212>  PRT
<213>  Homo sapiens

<400>  3171

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
1               5                   10                  15


Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
            20                  25                  30


Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
        35                  40                  45


Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
    50                  55                  60


Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
65                  70                  75                  80


Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                85                  90                  95


Val Arg Ile Cys Ser Lys Ser Tyr Leu Thr Leu Glu Asn Gly Lys Val 
            100                 105                 110


Phe Leu Thr Gly Gly Asp Leu Pro Ala Leu Asp Gly Ala Arg Val Asp 
        115                 120                 125


Phe Arg Cys Asp Pro Asp Phe His Leu Val Gly Ser Ser Arg Ser Ile 
    130                 135                 140


Cys Ser Gln Gly Gln Trp Ser Thr Pro Lys Pro His Cys Gln Val Asn 
145                 150                 155                 160


Arg Thr Pro His Ser Glu Arg Arg Ala Val Tyr Ile Gly Ala Leu Phe 
                165                 170                 175


Pro Met Ser Gly Gly Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val 
            180                 185                 190


Glu Met Ala Leu Glu Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp 
        195                 200                 205


Tyr Glu Leu Lys Leu Ile His His Asp Ser Lys Cys Asp Pro Gly Gln 
    210                 215                 220


Ala Thr Lys Tyr Leu Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile 
225                 230                 235                 240


Ile Leu Met Pro Gly Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala 
                245                 250                 255


Ala Arg Met Trp Asn Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro 
            260                 265                 270


Ala Leu Ser Asn Arg Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro 
        275                 280                 285


Ser Ala Thr Leu His Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp 
    290                 295                 300


Gly Trp Lys Lys Ile Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr 
305                 310                 315                 320


Ser Thr Leu Asp Asp Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu 
                325                 330                 335


Ile Thr Phe Arg Gln Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys 
            340                 345                 350


Asn Leu Lys Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu 
        355                 360                 365


Thr Glu Ala Arg Lys Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe 
    370                 375                 380


Gly Lys Lys Tyr Val Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp 
385                 390                 395                 400


Phe Lys Ile Tyr Asp Pro Ser Ile Asn Cys Thr Val Asp Glu Met Thr 
                405                 410                 415


Glu Ala Val Glu Gly His Ile Thr Thr Glu Ile Val Met Leu Asn Pro 
            420                 425                 430


Ala Asn Thr Arg Ser Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu 
        435                 440                 445


Lys Leu Thr Lys Arg Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe 
    450                 455                 460


Gln Glu Ala Pro Leu Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala 
465                 470                 475                 480


Leu Asn Lys Thr Ser Gly Gly Gly Gly Arg Ser Gly Val Arg Leu Glu 
                485                 490                 495


Asp Phe Asn Tyr Asn Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala 
            500                 505                 510


Met Asn Ser Ser Ser Phe Glu Gly Val Ser Gly His Val Val Phe Asp 
        515                 520                 525


Ala Ser Gly Ser Arg Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly 
    530                 535                 540


Gly Ser Tyr Lys Lys Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu 
545                 550                 555                 560


Ser Trp Ser Lys Thr Asp Lys Trp Ile Val Ile Ser Arg Thr His Ser 
                565                 570                 575


Pro Thr 



<210>  3172
<211>  4537
<212>  DNA
<213>  Homo sapiens

<400>  3172
ccctctcttc cccccgccct gccttccctt gcaccctcct tcttccctcc gcccgggagc     60

tctccctggt ccccggcgcc gcctccttcc ctcccggctc cccgctcccc gctcccgtgg    120

ctgccgccgc cccggggaag aagagacagg ggtggggttt gggggaagcg agagaggagg    180

ggagagaccc tggccaggct ggagcctgga ttcgagggga ggagggacgg gaggaggaga    240

aaggtggagg agaagggagg ggggagcggg gaggagcggc cgggcctggg gccttgaggc    300

ccggggagag ccggggagcc gggcccgcgc gccgagatgt tgctgctgct gctactggcg    360

ccactcttcc tccgcccccc gggcgcgggc ggggcgcaga cccccaacgc cacctcagaa    420

ggttgccaga tcatacaccc gccctgggaa gggggcatca ggtaccgggg cctgactcgg    480

gaccaggtga aggctatcaa cttcctgcca gtggactatg agattgagta tgtgtgccgg    540

ggggagcgcg aggtggtggg gcccaaggtc cgcaagtgcc tggccaacgg ctcctggaca    600

gatatggaca cacccagccg ctgtgtccga atctgctcca agtcttattt gaccctggaa    660

aatgggaagg ttttcctgac gggtggggac ctcccagctc tggacggagc ccgggtggat    720

ttccggtgtg accccgactt ccatctggtg ggcagctccc ggagcatctg tagtcagggc    780

cagtggagca cccccaagcc ccactgccag gtgaatcgaa cgccacactc agaacggcgc    840

gcagtgtaca tcggggcact gtttcccatg agcgggggct ggccaggggg ccaggcctgc    900

cagcccgcgg tggagatggc gctggaggac gtgaatagcc gcagggacat cctgccggac    960

tatgagctca agctcatcca ccacgacagc aagtgtgatc caggccaagc caccaagtac   1020

ctatatgagc tgctctacaa cgaccctatc aagatcatcc ttatgcctgg ctgcagctct   1080

gtctccacgc tggtggctga ggctgctagg atgtggaacc tcattgtgct ttcctatggc   1140

tccagctcac cagccctgtc aaaccggcag cgtttcccca ctttcttccg aacgcaccca   1200

tcagccacac tccacaaccc tacccgcgtg aaactctttg aaaagtgggg ctggaagaag   1260

attgctacca tccagcagac cactgaggtc ttcacttcga ctctggacga cctggaggaa   1320

cgagtgaagg aggctggaat tgagattact ttccgccaga gtttcttctc agatccagct   1380

gtgcccgtca aaaacctgaa gcgccaggat gcccgaatca tcgtgggact tttctatgag   1440

actgaagccc ggaaagtttt ttgtgaggtg tacaaggagc gtctctttgg gaagaagtac   1500

gtctggttcc tcattgggtg gtatgctgac aattggttca agatctacga cccttctatc   1560

aactgcacag tggatgagat gactgaggcg gtggagggcc acatcacaac tgagattgtc   1620

atgctgaatc ctgccaatac ccgcagcatt tccaacatga catcccagga atttgtggag   1680

aaactaacca agcgactgaa aagacaccct gaggagacag gaggcttcca ggaggcaccg   1740

ctggcctatg atgccatctg ggccttggca ctggccctga acaagacatc tggaggaggc   1800

ggccgttctg gtgtgcgcct ggaggacttc aactacaaca accagaccat taccgaccaa   1860

atctaccggg caatgaactc ttcgtccttt gagggtgtct ctggccatgt ggtgtttgat   1920

gccagcggct ctcggatggc atggacgctt atcgagcagc ttcagggtgg cagctacaag   1980

aagattggct actatgacag caccaaggat gatctttcct ggtccaaaac agataaatgg   2040

attggagggt cccccccagc tgaccagacc ctggtcatca agacattccg cttcctgtca   2100

cagaaactct ttatctccgt ctcagttctc tccagcctgg gcattgtcct agctgttgtc   2160

tgtctgtcct ttaacatcta caactcacat gtccgttata tccagaactc acagcccaac   2220

ctgaacaacc tgactgctgt gggctgctca ctggctttag ctgctgtctt ccccctgggg   2280

ctcgatggtt accacattgg gaggaaccag tttcctttcg tctgccaggc ccgcctctgg   2340

ctcctgggcc tgggctttag tctgggctac ggttccatgt tcaccaagat ttggtgggtc   2400

cacacggtct tcacaaagaa ggaagaaaag aaggagtgga ggaagactct ggaaccctgg   2460

aagctgtatg ccacagtggg cctgctggtg ggcatggatg tcctcactct cgccatctgg   2520

cagatcgtgg accctctgca ccggaccatt gagacatttg ccaaggagga acctaaggaa   2580

gatattgacg tctctattct gccccagctg gagcattgca gctccaggaa gatgaataca   2640

tggcttggca ttttctatgg ttacaagggg ctgctgctgc tgctgggaat cttccttgct   2700

tatgagacca agagtgtgtc cactgagaag atcaatgatc accgggctgt gggcatggct   2760

atctacaatg tggcagtcct gtgcctcatc actgctcctg tcaccatgat tctgtccagc   2820

cagcaggatg cagcctttgc ctttgcctct cttgccatag ttttctcctc ctatatcact   2880

cttgttgtgc tctttgtgcc caagatgcgc aggctgatca cccgagggga atggcagtcg   2940

gaggcgcagg acaccatgaa gacagggtca tcgaccaaca acaacgagga ggagaagtcc   3000

cggctgttgg agaaggagaa ccgtgaactg gaaaagatca ttgctgagaa agaggagcgt   3060

gtctctgaac tgcgccatca actccagtct cggcagcagc tccgctcccg gcgccaccca   3120

ccgacacccc cagaaccctc tgggggcctg cccaggggac cccctgagcc ccccgaccgg   3180

cttagctgtg atgggagtcg agtgcatttg ctttataagt gagggtaggg tgagggagga   3240

caggccagta gggggaggga aagggagagg ggaagggcag gggactcagg aagcaggggg   3300

tccccatccc cagctgggaa gaacatgcta tccaatctca tctcttgtaa atacatgtcc   3360

ccctgtgagt tctgggctga tttgggtctc tcatacctct gggaaacaga cctttttctc   3420

tcttactgct tcatgtaatt ttgtatcacc tcttcacaat ttagttcgta cctggcttga   3480

agctgctcac tgctcacacg ctgcctcctc agcagcctca ctgcatcttt ctcttcccat   3540

gcaacaccct cttctagtta ccacggcaac ccctgcagct cctctgcctt tgtgctctgt   3600

tcctgtccag caggggtctc ccaacaagtg ctctttccac cccaaagggg cctctccttt   3660

tctccactgt cataatctct ttccatctta cttgcccttc tatactttct cacatgtggc   3720

tccccctgaa ttttgcttcc tttgggagct cattcttttc gccaaggctc acatgctcct   3780

tgcctctgct ctgtgcactc acgctcagca cacatgcatc ctcccctctc ctgcgtgtgc   3840

ccactgaaca tgctcatgtg tacacacgct tttcccgtat gctttcttca tgttcagtca   3900

catgtgctct cgggtgccct gcattcacag ctacgtgtgc ccctctcatg gtcatgggtc   3960

tgcccttgag cgtgtttggg taggcatgtg caatttgtct agcatgctga gtcatgtctt   4020

tcctatttgc acacgtccat gtttatccat gtactttccc tgtgtaccct ccatgtacct   4080

tgtgtacttt cttcccttaa atcatggtat tcttctgaca gagccatatg taccctaccc   4140

tgcacattgt tatgcacttt tccccaattc atgtttggtg gggccatcca caccctctcc   4200

ttgtcacaga atctccattt ctgctcagat tccccccatc tccattgcat tcatgtacta   4260

ccctcagtct acactcacaa tcatcttctc ccaagactgc tcccttttgt tttgtgtttt   4320

tttgagggga attaaggaaa aataagtggg ggcaggtttg gagagctgct tccagtggat   4380

agttgatgag aatcctgacc aaaggaaggc acccttgact gttgggatag acagatggac   4440

ctatggggtg ggaggtggtg tccctttcac actgtggtgt ctcttgggga aggatctccc   4500

cgaatctcaa taaaccagtg aacagtgtga ctcggca                            4537


<210>  3173
<211>  961
<212>  PRT
<213>  Homo sapiens

<400>  3173

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
1               5                   10                  15


Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
            20                  25                  30


Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
        35                  40                  45


Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
    50                  55                  60


Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
65                  70                  75                  80


Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                85                  90                  95


Val Arg Ile Cys Ser Lys Ser Tyr Leu Thr Leu Glu Asn Gly Lys Val 
            100                 105                 110


Phe Leu Thr Gly Gly Asp Leu Pro Ala Leu Asp Gly Ala Arg Val Asp 
        115                 120                 125


Phe Arg Cys Asp Pro Asp Phe His Leu Val Gly Ser Ser Arg Ser Ile 
    130                 135                 140


Cys Ser Gln Gly Gln Trp Ser Thr Pro Lys Pro His Cys Gln Val Asn 
145                 150                 155                 160


Arg Thr Pro His Ser Glu Arg Arg Ala Val Tyr Ile Gly Ala Leu Phe 
                165                 170                 175


Pro Met Ser Gly Gly Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val 
            180                 185                 190


Glu Met Ala Leu Glu Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp 
        195                 200                 205


Tyr Glu Leu Lys Leu Ile His His Asp Ser Lys Cys Asp Pro Gly Gln 
    210                 215                 220


Ala Thr Lys Tyr Leu Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile 
225                 230                 235                 240


Ile Leu Met Pro Gly Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala 
                245                 250                 255


Ala Arg Met Trp Asn Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro 
            260                 265                 270


Ala Leu Ser Asn Arg Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro 
        275                 280                 285


Ser Ala Thr Leu His Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp 
    290                 295                 300


Gly Trp Lys Lys Ile Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr 
305                 310                 315                 320


Ser Thr Leu Asp Asp Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu 
                325                 330                 335


Ile Thr Phe Arg Gln Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys 
            340                 345                 350


Asn Leu Lys Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu 
        355                 360                 365


Thr Glu Ala Arg Lys Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe 
    370                 375                 380


Gly Lys Lys Tyr Val Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp 
385                 390                 395                 400


Phe Lys Ile Tyr Asp Pro Ser Ile Asn Cys Thr Val Asp Glu Met Thr 
                405                 410                 415


Glu Ala Val Glu Gly His Ile Thr Thr Glu Ile Val Met Leu Asn Pro 
            420                 425                 430


Ala Asn Thr Arg Ser Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu 
        435                 440                 445


Lys Leu Thr Lys Arg Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe 
    450                 455                 460


Gln Glu Ala Pro Leu Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala 
465                 470                 475                 480


Leu Asn Lys Thr Ser Gly Gly Gly Gly Arg Ser Gly Val Arg Leu Glu 
                485                 490                 495


Asp Phe Asn Tyr Asn Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala 
            500                 505                 510


Met Asn Ser Ser Ser Phe Glu Gly Val Ser Gly His Val Val Phe Asp 
        515                 520                 525


Ala Ser Gly Ser Arg Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly 
    530                 535                 540


Gly Ser Tyr Lys Lys Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu 
545                 550                 555                 560


Ser Trp Ser Lys Thr Asp Lys Trp Ile Gly Gly Ser Pro Pro Ala Asp 
                565                 570                 575


Gln Thr Leu Val Ile Lys Thr Phe Arg Phe Leu Ser Gln Lys Leu Phe 
            580                 585                 590


Ile Ser Val Ser Val Leu Ser Ser Leu Gly Ile Val Leu Ala Val Val 
        595                 600                 605


Cys Leu Ser Phe Asn Ile Tyr Asn Ser His Val Arg Tyr Ile Gln Asn 
    610                 615                 620


Ser Gln Pro Asn Leu Asn Asn Leu Thr Ala Val Gly Cys Ser Leu Ala 
625                 630                 635                 640


Leu Ala Ala Val Phe Pro Leu Gly Leu Asp Gly Tyr His Ile Gly Arg 
                645                 650                 655


Asn Gln Phe Pro Phe Val Cys Gln Ala Arg Leu Trp Leu Leu Gly Leu 
            660                 665                 670


Gly Phe Ser Leu Gly Tyr Gly Ser Met Phe Thr Lys Ile Trp Trp Val 
        675                 680                 685


His Thr Val Phe Thr Lys Lys Glu Glu Lys Lys Glu Trp Arg Lys Thr 
    690                 695                 700


Leu Glu Pro Trp Lys Leu Tyr Ala Thr Val Gly Leu Leu Val Gly Met 
705                 710                 715                 720


Asp Val Leu Thr Leu Ala Ile Trp Gln Ile Val Asp Pro Leu His Arg 
                725                 730                 735


Thr Ile Glu Thr Phe Ala Lys Glu Glu Pro Lys Glu Asp Ile Asp Val 
            740                 745                 750


Ser Ile Leu Pro Gln Leu Glu His Cys Ser Ser Arg Lys Met Asn Thr 
        755                 760                 765


Trp Leu Gly Ile Phe Tyr Gly Tyr Lys Gly Leu Leu Leu Leu Leu Gly 
    770                 775                 780


Ile Phe Leu Ala Tyr Glu Thr Lys Ser Val Ser Thr Glu Lys Ile Asn 
785                 790                 795                 800


Asp His Arg Ala Val Gly Met Ala Ile Tyr Asn Val Ala Val Leu Cys 
                805                 810                 815


Leu Ile Thr Ala Pro Val Thr Met Ile Leu Ser Ser Gln Gln Asp Ala 
            820                 825                 830


Ala Phe Ala Phe Ala Ser Leu Ala Ile Val Phe Ser Ser Tyr Ile Thr 
        835                 840                 845


Leu Val Val Leu Phe Val Pro Lys Met Arg Arg Leu Ile Thr Arg Gly 
    850                 855                 860


Glu Trp Gln Ser Glu Ala Gln Asp Thr Met Lys Thr Gly Ser Ser Thr 
865                 870                 875                 880


Asn Asn Asn Glu Glu Glu Lys Ser Arg Leu Leu Glu Lys Glu Asn Arg 
                885                 890                 895


Glu Leu Glu Lys Ile Ile Ala Glu Lys Glu Glu Arg Val Ser Glu Leu 
            900                 905                 910


Arg His Gln Leu Gln Ser Arg Gln Gln Leu Arg Ser Arg Arg His Pro 
        915                 920                 925


Pro Thr Pro Pro Glu Pro Ser Gly Gly Leu Pro Arg Gly Pro Pro Glu 
    930                 935                 940


Pro Pro Asp Arg Leu Ser Cys Asp Gly Ser Arg Val His Leu Leu Tyr 
945                 950                 955                 960


Lys 



<210>  3174
<211>  4351
<212>  DNA
<213>  Homo sapiens

<400>  3174
ccctctcttc cccccgccct gccttccctt gcaccctcct tcttccctcc gcccgggagc     60

tctccctggt ccccggcgcc gcctccttcc ctcccggctc cccgctcccc gctcccgtgg    120

ctgccgccgc cccggggaag aagagacagg ggtggggttt gggggaagcg agagaggagg    180

ggagagaccc tggccaggct ggagcctgga ttcgagggga ggagggacgg gaggaggaga    240

aaggtggagg agaagggagg ggggagcggg gaggagcggc cgggcctggg gccttgaggc    300

ccggggagag ccggggagcc gggcccgcgc gccgagatgt tgctgctgct gctactggcg    360

ccactcttcc tccgcccccc gggcgcgggc ggggcgcaga cccccaacgc cacctcagaa    420

ggttgccaga tcatacaccc gccctgggaa gggggcatca ggtaccgggg cctgactcgg    480

gaccaggtga aggctatcaa cttcctgcca gtggactatg agattgagta tgtgtgccgg    540

ggggagcgcg aggtggtggg gcccaaggtc cgcaagtgcc tggccaacgg ctcctggaca    600

gatatggaca cacccagccg ctgtgtgaat cgaacgccac actcagaacg gcgcgcagtg    660

tacatcgggg cactgtttcc catgagcggg ggctggccag ggggccaggc ctgccagccc    720

gcggtggaga tggcgctgga ggacgtgaat agccgcaggg acatcctgcc ggactatgag    780

ctcaagctca tccaccacga cagcaagtgt gatccaggcc aagccaccaa gtacctatat    840

gagctgctct acaacgaccc tatcaagatc atccttatgc ctggctgcag ctctgtctcc    900

acgctggtgg ctgaggctgc taggatgtgg aacctcattg tgctttccta tggctccagc    960

tcaccagccc tgtcaaaccg gcagcgtttc cccactttct tccgaacgca cccatcagcc   1020

acactccaca accctacccg cgtgaaactc tttgaaaagt ggggctggaa gaagattgct   1080

accatccagc agaccactga ggtcttcact tcgactctgg acgacctgga ggaacgagtg   1140

aaggaggctg gaattgagat tactttccgc cagagtttct tctcagatcc agctgtgccc   1200

gtcaaaaacc tgaagcgcca ggatgcccga atcatcgtgg gacttttcta tgagactgaa   1260

gcccggaaag ttttttgtga ggtgtacaag gagcgtctct ttgggaagaa gtacgtctgg   1320

ttcctcattg ggtggtatgc tgacaattgg ttcaagatct acgacccttc tatcaactgc   1380

acagtggatg agatgactga ggcggtggag ggccacatca caactgagat tgtcatgctg   1440

aatcctgcca atacccgcag catttccaac atgacatccc aggaatttgt ggagaaacta   1500

accaagcgac tgaaaagaca ccctgaggag acaggaggct tccaggaggc accgctggcc   1560

tatgatgcca tctgggcctt ggcactggcc ctgaacaaga catctggagg aggcggccgt   1620

tctggtgtgc gcctggagga cttcaactac aacaaccaga ccattaccga ccaaatctac   1680

cgggcaatga actcttcgtc ctttgagggt gtctctggcc atgtggtgtt tgatgccagc   1740

ggctctcgga tggcatggac gcttatcgag cagcttcagg gtggcagcta caagaagatt   1800

ggctactatg acagcaccaa ggatgatctt tcctggtcca aaacagataa atggattgga   1860

gggtcccccc cagctgacca gaccctggtc atcaagacat tccgcttcct gtcacagaaa   1920

ctctttatct ccgtctcagt tctctccagc ctgggcattg tcctagctgt tgtctgtctg   1980

tcctttaaca tctacaactc acatgtccgt tatatccaga actcacagcc caacctgaac   2040

aacctgactg ctgtgggctg ctcactggct ttagctgctg tcttccccct ggggctcgat   2100

ggttaccaca ttgggaggaa ccagtttcct ttcgtctgcc aggcccgcct ctggctcctg   2160

ggcctgggct ttagtctggg ctacggttcc atgttcacca agatttggtg ggtccacacg   2220

gtcttcacaa agaaggaaga aaagaaggag tggaggaaga ctctggaacc ctggaagctg   2280

tatgccacag tgggcctgct ggtgggcatg gatgtcctca ctctcgccat ctggcagatc   2340

gtggaccctc tgcaccggac cattgagaca tttgccaagg aggaacctaa ggaagatatt   2400

gacgtctcta ttctgcccca gctggagcat tgcagctcca ggaagatgaa tacatggctt   2460

ggcattttct atggttacaa ggggctgctg ctgctgctgg gaatcttcct tgcttatgag   2520

accaagagtg tgtccactga gaagatcaat gatcaccggg ctgtgggcat ggctatctac   2580

aatgtggcag tcctgtgcct catcactgct cctgtcacca tgattctgtc cagccagcag   2640

gatgcagcct ttgcctttgc ctctcttgcc atagttttct cctcctatat cactcttgtt   2700

gtgctctttg tgcccaagat gcgcaggctg atcacccgag gggaatggca gtcggaggcg   2760

caggacacca tgaagacagg gtcatcgacc aacaacaacg aggaggagaa gtcccggctg   2820

ttggagaagg agaaccgtga actggaaaag atcattgctg agaaagagga gcgtgtctct   2880

gaactgcgcc atcaactcca gtctcggcag cagctccgct cccggcgcca cccaccgaca   2940

cccccagaac cctctggggg cctgcccagg ggaccccctg agccccccga ccggcttagc   3000

tgtgatggga gtcgagtgca tttgctttat aagtgagggt agggtgaggg aggacaggcc   3060

agtaggggga gggaaaggga gaggggaagg gcaggggact caggaagcag ggggtcccca   3120

tccccagctg ggaagaacat gctatccaat ctcatctctt gtaaatacat gtccccctgt   3180

gagttctggg ctgatttggg tctctcatac ctctgggaaa cagacctttt tctctcttac   3240

tgcttcatgt aattttgtat cacctcttca caatttagtt cgtacctggc ttgaagctgc   3300

tcactgctca cacgctgcct cctcagcagc ctcactgcat ctttctcttc ccatgcaaca   3360

ccctcttcta gttaccacgg caacccctgc agctcctctg cctttgtgct ctgttcctgt   3420

ccagcagggg tctcccaaca agtgctcttt ccaccccaaa ggggcctctc cttttctcca   3480

ctgtcataat ctctttccat cttacttgcc cttctatact ttctcacatg tggctccccc   3540

tgaattttgc ttcctttggg agctcattct tttcgccaag gctcacatgc tccttgcctc   3600

tgctctgtgc actcacgctc agcacacatg catcctcccc tctcctgcgt gtgcccactg   3660

aacatgctca tgtgtacaca cgcttttccc gtatgctttc ttcatgttca gtcacatgtg   3720

ctctcgggtg ccctgcattc acagctacgt gtgcccctct catggtcatg ggtctgccct   3780

tgagcgtgtt tgggtaggca tgtgcaattt gtctagcatg ctgagtcatg tctttcctat   3840

ttgcacacgt ccatgtttat ccatgtactt tccctgtgta ccctccatgt accttgtgta   3900

ctttcttccc ttaaatcatg gtattcttct gacagagcca tatgtaccct accctgcaca   3960

ttgttatgca cttttcccca attcatgttt ggtggggcca tccacaccct ctccttgtca   4020

cagaatctcc atttctgctc agattccccc catctccatt gcattcatgt actaccctca   4080

gtctacactc acaatcatct tctcccaaga ctgctccctt ttgttttgtg tttttttgag   4140

gggaattaag gaaaaataag tgggggcagg tttggagagc tgcttccagt ggatagttga   4200

tgagaatcct gaccaaagga aggcaccctt gactgttggg atagacagat ggacctatgg   4260

ggtgggaggt ggtgtccctt tcacactgtg gtgtctcttg gggaaggatc tccccgaatc   4320

tcaataaacc agtgaacagt gtgactcggc a                                  4351


<210>  3175
<211>  899
<212>  PRT
<213>  Homo sapiens

<400>  3175

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
1               5                   10                  15


Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
            20                  25                  30


Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
        35                  40                  45


Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
    50                  55                  60


Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
65                  70                  75                  80


Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                85                  90                  95


Val Asn Arg Thr Pro His Ser Glu Arg Arg Ala Val Tyr Ile Gly Ala 
            100                 105                 110


Leu Phe Pro Met Ser Gly Gly Trp Pro Gly Gly Gln Ala Cys Gln Pro 
        115                 120                 125


Ala Val Glu Met Ala Leu Glu Asp Val Asn Ser Arg Arg Asp Ile Leu 
    130                 135                 140


Pro Asp Tyr Glu Leu Lys Leu Ile His His Asp Ser Lys Cys Asp Pro 
145                 150                 155                 160


Gly Gln Ala Thr Lys Tyr Leu Tyr Glu Leu Leu Tyr Asn Asp Pro Ile 
                165                 170                 175


Lys Ile Ile Leu Met Pro Gly Cys Ser Ser Val Ser Thr Leu Val Ala 
            180                 185                 190


Glu Ala Ala Arg Met Trp Asn Leu Ile Val Leu Ser Tyr Gly Ser Ser 
        195                 200                 205


Ser Pro Ala Leu Ser Asn Arg Gln Arg Phe Pro Thr Phe Phe Arg Thr 
    210                 215                 220


His Pro Ser Ala Thr Leu His Asn Pro Thr Arg Val Lys Leu Phe Glu 
225                 230                 235                 240


Lys Trp Gly Trp Lys Lys Ile Ala Thr Ile Gln Gln Thr Thr Glu Val 
                245                 250                 255


Phe Thr Ser Thr Leu Asp Asp Leu Glu Glu Arg Val Lys Glu Ala Gly 
            260                 265                 270


Ile Glu Ile Thr Phe Arg Gln Ser Phe Phe Ser Asp Pro Ala Val Pro 
        275                 280                 285


Val Lys Asn Leu Lys Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe 
    290                 295                 300


Tyr Glu Thr Glu Ala Arg Lys Val Phe Cys Glu Val Tyr Lys Glu Arg 
305                 310                 315                 320


Leu Phe Gly Lys Lys Tyr Val Trp Phe Leu Ile Gly Trp Tyr Ala Asp 
                325                 330                 335


Asn Trp Phe Lys Ile Tyr Asp Pro Ser Ile Asn Cys Thr Val Asp Glu 
            340                 345                 350


Met Thr Glu Ala Val Glu Gly His Ile Thr Thr Glu Ile Val Met Leu 
        355                 360                 365


Asn Pro Ala Asn Thr Arg Ser Ile Ser Asn Met Thr Ser Gln Glu Phe 
    370                 375                 380


Val Glu Lys Leu Thr Lys Arg Leu Lys Arg His Pro Glu Glu Thr Gly 
385                 390                 395                 400


Gly Phe Gln Glu Ala Pro Leu Ala Tyr Asp Ala Ile Trp Ala Leu Ala 
                405                 410                 415


Leu Ala Leu Asn Lys Thr Ser Gly Gly Gly Gly Arg Ser Gly Val Arg 
            420                 425                 430


Leu Glu Asp Phe Asn Tyr Asn Asn Gln Thr Ile Thr Asp Gln Ile Tyr 
        435                 440                 445


Arg Ala Met Asn Ser Ser Ser Phe Glu Gly Val Ser Gly His Val Val 
    450                 455                 460


Phe Asp Ala Ser Gly Ser Arg Met Ala Trp Thr Leu Ile Glu Gln Leu 
465                 470                 475                 480


Gln Gly Gly Ser Tyr Lys Lys Ile Gly Tyr Tyr Asp Ser Thr Lys Asp 
                485                 490                 495


Asp Leu Ser Trp Ser Lys Thr Asp Lys Trp Ile Gly Gly Ser Pro Pro 
            500                 505                 510


Ala Asp Gln Thr Leu Val Ile Lys Thr Phe Arg Phe Leu Ser Gln Lys 
        515                 520                 525


Leu Phe Ile Ser Val Ser Val Leu Ser Ser Leu Gly Ile Val Leu Ala 
    530                 535                 540


Val Val Cys Leu Ser Phe Asn Ile Tyr Asn Ser His Val Arg Tyr Ile 
545                 550                 555                 560


Gln Asn Ser Gln Pro Asn Leu Asn Asn Leu Thr Ala Val Gly Cys Ser 
                565                 570                 575


Leu Ala Leu Ala Ala Val Phe Pro Leu Gly Leu Asp Gly Tyr His Ile 
            580                 585                 590


Gly Arg Asn Gln Phe Pro Phe Val Cys Gln Ala Arg Leu Trp Leu Leu 
        595                 600                 605


Gly Leu Gly Phe Ser Leu Gly Tyr Gly Ser Met Phe Thr Lys Ile Trp 
    610                 615                 620


Trp Val His Thr Val Phe Thr Lys Lys Glu Glu Lys Lys Glu Trp Arg 
625                 630                 635                 640


Lys Thr Leu Glu Pro Trp Lys Leu Tyr Ala Thr Val Gly Leu Leu Val 
                645                 650                 655


Gly Met Asp Val Leu Thr Leu Ala Ile Trp Gln Ile Val Asp Pro Leu 
            660                 665                 670


His Arg Thr Ile Glu Thr Phe Ala Lys Glu Glu Pro Lys Glu Asp Ile 
        675                 680                 685


Asp Val Ser Ile Leu Pro Gln Leu Glu His Cys Ser Ser Arg Lys Met 
    690                 695                 700


Asn Thr Trp Leu Gly Ile Phe Tyr Gly Tyr Lys Gly Leu Leu Leu Leu 
705                 710                 715                 720


Leu Gly Ile Phe Leu Ala Tyr Glu Thr Lys Ser Val Ser Thr Glu Lys 
                725                 730                 735


Ile Asn Asp His Arg Ala Val Gly Met Ala Ile Tyr Asn Val Ala Val 
            740                 745                 750


Leu Cys Leu Ile Thr Ala Pro Val Thr Met Ile Leu Ser Ser Gln Gln 
        755                 760                 765


Asp Ala Ala Phe Ala Phe Ala Ser Leu Ala Ile Val Phe Ser Ser Tyr 
    770                 775                 780


Ile Thr Leu Val Val Leu Phe Val Pro Lys Met Arg Arg Leu Ile Thr 
785                 790                 795                 800


Arg Gly Glu Trp Gln Ser Glu Ala Gln Asp Thr Met Lys Thr Gly Ser 
                805                 810                 815


Ser Thr Asn Asn Asn Glu Glu Glu Lys Ser Arg Leu Leu Glu Lys Glu 
            820                 825                 830


Asn Arg Glu Leu Glu Lys Ile Ile Ala Glu Lys Glu Glu Arg Val Ser 
        835                 840                 845


Glu Leu Arg His Gln Leu Gln Ser Arg Gln Gln Leu Arg Ser Arg Arg 
    850                 855                 860


His Pro Pro Thr Pro Pro Glu Pro Ser Gly Gly Leu Pro Arg Gly Pro 
865                 870                 875                 880


Pro Glu Pro Pro Asp Arg Leu Ser Cys Asp Gly Ser Arg Val His Leu 
                885                 890                 895


Leu Tyr Lys 



<210>  3176
<211>  4406
<212>  DNA
<213>  Homo sapiens

<400>  3176
ccctctcttc cccccgccct gccttccctt gcaccctcct tcttccctcc gcccgggagc     60

tctccctggt ccccggcgcc gcctccttcc ctcccggctc cccgctcccc gctcccgtgg    120

ctgccgccgc cccggggaag aagagacagg ggtggggttt gggggaagcg agagaggagg    180

ggagagaccc tggccaggct ggagcctgga ttcgagggga ggagggacgg gaggaggaga    240

aaggtggagg agaagggagg ggggagcggg gaggagcggc cgggcctggg gccttgaggc    300

ccggggagag ccggggagcc gggcccgcgc gccgagatgt tgctgctgct gctactggcg    360

ccactcttcc tccgcccccc gggcgcgggc ggggcgcaga cccccaacgc cacctcagaa    420

ggttgccaga tcatacaccc gccctgggaa gggggcatca ggtaccgggg cctgactcgg    480

gaccaggtga aggctatcaa cttcctgcca gtggactatg agattgagta tgtgtgccgg    540

ggggagcgcg aggtggtggg gcccaaggtc cgcaagtgcc tggccaacgg ctcctggaca    600

gatatggaca cacccagccg ctgtgtccga atctgctcca agtcttattt gaccctggaa    660

aatgggaagg ttttcctgac gggtggggac ctcccagctc tggacggagc ccgggtggat    720

ttccggtgtg accccgactt ccatctgtga atcgaacgcc acactcagaa cggcgcgcag    780

tgtacatcgg ggcactgttt cccatgagcg ggggctggcc agggggccag gcctgccagc    840

ccgcggtgga gatggcgctg gaggacgtga atagccgcag ggacatcctg ccggactatg    900

agctcaagct catccaccac gacagcaagt gtgatccagg ccaagccacc aagtacctat    960

atgagctgct ctacaacgac cctatcaaga tcatccttat gcctggctgc agctctgtct   1020

ccacgctggt ggctgaggct gctaggatgt ggaacctcat tgtgctttcc tatggctcca   1080

gctcaccagc cctgtcaaac cggcagcgtt tccccacttt cttccgaacg cacccatcag   1140

ccacactcca caaccctacc cgcgtgaaac tctttgaaaa gtggggctgg aagaagattg   1200

ctaccatcca gcagaccact gaggtcttca cttcgactct ggacgacctg gaggaacgag   1260

tgaaggaggc tggaattgag attactttcc gccagagttt cttctcagat ccagctgtgc   1320

ccgtcaaaaa cctgaagcgc caggatgccc gaatcatcgt gggacttttc tatgagactg   1380

aagcccggaa agttttttgt gaggtgtaca aggagcgtct ctttgggaag aagtacgtct   1440

ggttcctcat tgggtggtat gctgacaatt ggttcaagat ctacgaccct tctatcaact   1500

gcacagtgga tgagatgact gaggcggtgg agggccacat cacaactgag attgtcatgc   1560

tgaatcctgc caatacccgc agcatttcca acatgacatc ccaggaattt gtggagaaac   1620

taaccaagcg actgaaaaga caccctgagg agacaggagg cttccaggag gcaccgctgg   1680

cctatgatgc catctgggcc ttggcactgg ccctgaacaa gacatctgga ggaggcggcc   1740

gttctggtgt gcgcctggag gacttcaact acaacaacca gaccattacc gaccaaatct   1800

accgggcaat gaactcttcg tcctttgagg gtgtctctgg ccatgtggtg tttgatgcca   1860

gcggctctcg gatggcatgg acgcttatcg agcagcttca gggtggcagc tacaagaaga   1920

ttggctacta tgacagcacc aaggatgatc tttcctggtc caaaacagat aaatggattg   1980

gagggtcccc cccagctgac cagaccctgg tcatcaagac attccgcttc ctgtcacaga   2040

aactctttat ctccgtctca gttctctcca gcctgggcat tgtcctagct gttgtctgtc   2100

tgtcctttaa catctacaac tcacatgtcc gttatatcca gaactcacag cccaacctga   2160

acaacctgac tgctgtgggc tgctcactgg ctttagctgc tgtcttcccc ctggggctcg   2220

atggttacca cattgggagg aaccagtttc ctttcgtctg ccaggcccgc ctctggctcc   2280

tgggcctggg ctttagtctg ggctacggtt ccatgttcac caagatttgg tgggtccaca   2340

cggtcttcac aaagaaggaa gaaaagaagg agtggaggaa gactctggaa ccctggaagc   2400

tgtatgccac agtgggcctg ctggtgggca tggatgtcct cactctcgcc atctggcaga   2460

tcgtggaccc tctgcaccgg accattgaga catttgccaa ggaggaacct aaggaagata   2520

ttgacgtctc tattctgccc cagctggagc attgcagctc caggaagatg aatacatggc   2580

ttggcatttt ctatggttac aaggggctgc tgctgctgct gggaatcttc cttgcttatg   2640

agaccaagag tgtgtccact gagaagatca atgatcaccg ggctgtgggc atggctatct   2700

acaatgtggc agtcctgtgc ctcatcactg ctcctgtcac catgattctg tccagccagc   2760

aggatgcagc ctttgccttt gcctctcttg ccatagtttt ctcctcctat atcactcttg   2820

ttgtgctctt tgtgcccaag atgcgcaggc tgatcacccg aggggaatgg cagtcggagg   2880

cgcaggacac catgaagaca gggtcatcga ccaacaacaa cgaggaggag aagtcccggc   2940

tgttggagaa ggagaaccgt gaactggaaa agatcattgc tgagaaagag gagcgtgtct   3000

ctgaactgcg ccatcaactc cagtctcggc agcagctccg ctcccggcgc cacccaccga   3060

cacccccaga accctctggg ggcctgccca ggggaccccc tgagcccccc gaccggctta   3120

gctgtgatgg gagtcgagtg catttgcttt ataagtgagg gtagggtgag ggaggacagg   3180

ccagtagggg gagggaaagg gagaggggaa gggcagggga ctcaggaagc agggggtccc   3240

catccccagc tgggaagaac atgctatcca atctcatctc ttgtaaatac atgtccccct   3300

gtgagttctg ggctgatttg ggtctctcat acctctggga aacagacctt tttctctctt   3360

actgcttcat gtaattttgt atcacctctt cacaatttag ttcgtacctg gcttgaagct   3420

gctcactgct cacacgctgc ctcctcagca gcctcactgc atctttctct tcccatgcaa   3480

caccctcttc tagttaccac ggcaacccct gcagctcctc tgcctttgtg ctctgttcct   3540

gtccagcagg ggtctcccaa caagtgctct ttccacccca aaggggcctc tccttttctc   3600

cactgtcata atctctttcc atcttacttg cccttctata ctttctcaca tgtggctccc   3660

cctgaatttt gcttcctttg ggagctcatt cttttcgcca aggctcacat gctccttgcc   3720

tctgctctgt gcactcacgc tcagcacaca tgcatcctcc cctctcctgc gtgtgcccac   3780

tgaacatgct catgtgtaca cacgcttttc ccgtatgctt tcttcatgtt cagtcacatg   3840

tgctctcggg tgccctgcat tcacagctac gtgtgcccct ctcatggtca tgggtctgcc   3900

cttgagcgtg tttgggtagg catgtgcaat ttgtctagca tgctgagtca tgtctttcct   3960

atttgcacac gtccatgttt atccatgtac tttccctgtg taccctccat gtaccttgtg   4020

tactttcttc ccttaaatca tggtattctt ctgacagagc catatgtacc ctaccctgca   4080

cattgttatg cacttttccc caattcatgt ttggtggggc catccacacc ctctccttgt   4140

cacagaataa tcatcttctc ccaagactgc tcccttttgt tttgtgtttt tttgagggga   4200

attaaggaaa aataagtggg ggcaggtttg gagagctgct tccagtggat agttgatgag   4260

aatcctgacc aaaggaaggc acccttgact gttgggatag acagatggac ctatggggtg   4320

ggaggtggtg tccctttcac actgtggtgt ctcttgggga aggatctccc cgaatctcaa   4380

taaaccagtg aacagtgtga ctcggc                                        4406


<210>  3177
<211>  784
<212>  PRT
<213>  Homo sapiens

<400>  3177

Met Ser Gly Gly Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val Glu 
1               5                   10                  15


Met Ala Leu Glu Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp Tyr 
            20                  25                  30


Glu Leu Lys Leu Ile His His Asp Ser Lys Cys Asp Pro Gly Gln Ala 
        35                  40                  45


Thr Lys Tyr Leu Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile Ile 
    50                  55                  60


Leu Met Pro Gly Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala Ala 
65                  70                  75                  80


Arg Met Trp Asn Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro Ala 
                85                  90                  95


Leu Ser Asn Arg Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro Ser 
            100                 105                 110


Ala Thr Leu His Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp Gly 
        115                 120                 125


Trp Lys Lys Ile Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr Ser 
    130                 135                 140


Thr Leu Asp Asp Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu Ile 
145                 150                 155                 160


Thr Phe Arg Gln Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys Asn 
                165                 170                 175


Leu Lys Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu Thr 
            180                 185                 190


Glu Ala Arg Lys Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe Gly 
        195                 200                 205


Lys Lys Tyr Val Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp Phe 
    210                 215                 220


Lys Ile Tyr Asp Pro Ser Ile Asn Cys Thr Val Asp Glu Met Thr Glu 
225                 230                 235                 240


Ala Val Glu Gly His Ile Thr Thr Glu Ile Val Met Leu Asn Pro Ala 
                245                 250                 255


Asn Thr Arg Ser Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu Lys 
            260                 265                 270


Leu Thr Lys Arg Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe Gln 
        275                 280                 285


Glu Ala Pro Leu Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala Leu 
    290                 295                 300


Asn Lys Thr Ser Gly Gly Gly Gly Arg Ser Gly Val Arg Leu Glu Asp 
305                 310                 315                 320


Phe Asn Tyr Asn Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala Met 
                325                 330                 335


Asn Ser Ser Ser Phe Glu Gly Val Ser Gly His Val Val Phe Asp Ala 
            340                 345                 350


Ser Gly Ser Arg Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly Gly 
        355                 360                 365


Ser Tyr Lys Lys Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu Ser 
    370                 375                 380


Trp Ser Lys Thr Asp Lys Trp Ile Gly Gly Ser Pro Pro Ala Asp Gln 
385                 390                 395                 400


Thr Leu Val Ile Lys Thr Phe Arg Phe Leu Ser Gln Lys Leu Phe Ile 
                405                 410                 415


Ser Val Ser Val Leu Ser Ser Leu Gly Ile Val Leu Ala Val Val Cys 
            420                 425                 430


Leu Ser Phe Asn Ile Tyr Asn Ser His Val Arg Tyr Ile Gln Asn Ser 
        435                 440                 445


Gln Pro Asn Leu Asn Asn Leu Thr Ala Val Gly Cys Ser Leu Ala Leu 
    450                 455                 460


Ala Ala Val Phe Pro Leu Gly Leu Asp Gly Tyr His Ile Gly Arg Asn 
465                 470                 475                 480


Gln Phe Pro Phe Val Cys Gln Ala Arg Leu Trp Leu Leu Gly Leu Gly 
                485                 490                 495


Phe Ser Leu Gly Tyr Gly Ser Met Phe Thr Lys Ile Trp Trp Val His 
            500                 505                 510


Thr Val Phe Thr Lys Lys Glu Glu Lys Lys Glu Trp Arg Lys Thr Leu 
        515                 520                 525


Glu Pro Trp Lys Leu Tyr Ala Thr Val Gly Leu Leu Val Gly Met Asp 
    530                 535                 540


Val Leu Thr Leu Ala Ile Trp Gln Ile Val Asp Pro Leu His Arg Thr 
545                 550                 555                 560


Ile Glu Thr Phe Ala Lys Glu Glu Pro Lys Glu Asp Ile Asp Val Ser 
                565                 570                 575


Ile Leu Pro Gln Leu Glu His Cys Ser Ser Arg Lys Met Asn Thr Trp 
            580                 585                 590


Leu Gly Ile Phe Tyr Gly Tyr Lys Gly Leu Leu Leu Leu Leu Gly Ile 
        595                 600                 605


Phe Leu Ala Tyr Glu Thr Lys Ser Val Ser Thr Glu Lys Ile Asn Asp 
    610                 615                 620


His Arg Ala Val Gly Met Ala Ile Tyr Asn Val Ala Val Leu Cys Leu 
625                 630                 635                 640


Ile Thr Ala Pro Val Thr Met Ile Leu Ser Ser Gln Gln Asp Ala Ala 
                645                 650                 655


Phe Ala Phe Ala Ser Leu Ala Ile Val Phe Ser Ser Tyr Ile Thr Leu 
            660                 665                 670


Val Val Leu Phe Val Pro Lys Met Arg Arg Leu Ile Thr Arg Gly Glu 
        675                 680                 685


Trp Gln Ser Glu Ala Gln Asp Thr Met Lys Thr Gly Ser Ser Thr Asn 
    690                 695                 700


Asn Asn Glu Glu Glu Lys Ser Arg Leu Leu Glu Lys Glu Asn Arg Glu 
705                 710                 715                 720


Leu Glu Lys Ile Ile Ala Glu Lys Glu Glu Arg Val Ser Glu Leu Arg 
                725                 730                 735


His Gln Leu Gln Ser Arg Gln Gln Leu Arg Ser Arg Arg His Pro Pro 
            740                 745                 750


Thr Pro Pro Glu Pro Ser Gly Gly Leu Pro Arg Gly Pro Pro Glu Pro 
        755                 760                 765


Pro Asp Arg Leu Ser Cys Asp Gly Ser Arg Val His Leu Leu Tyr Lys 
    770                 775                 780


<210>  3178
<211>  579
<212>  DNA
<213>  Homo sapiens

<400>  3178
cattatcttt tagatccccc ttggccttat tagcattgtt cgattcatgg tcacaaattg     60

caaacctacc ctctgcctgg aaagccacct tcccacctgt agggtaaggg tgaggcatgt    120

gtggcccaga ctggcctatt tctagatatt caacaagccc ttgcctgact gacagcagct    180

tgccaccatt gctttcctgt gtgaatccca ggaaaaagtg atgtggtctg ggcaagttgg    240

gtggacataa gggatagggg acacagggtg aggtttgcta ggtcagaggg gttggattgg    300

agaggagggc cccctttcca tttcagagta ggtgaagggc agagagggga tggggattga    360

gtgaggagca ttgtggtcct tgttgctcaa gtgactctct cctgccatcc taggcatttt    420

ctatggttac aaggggctgc tgctgctgct gggaatcttc cttgcttatg agaccaagag    480

tgtgtccact gagaagatca atgatcaccg ggctgtgggc atggctatct acaatgtggc    540

agtcctgtgc ctcatcactg ctcctgtcac catgattct                           579


<210>  3179
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  3179

Met Val Thr Arg Gly Cys Cys Cys Cys Trp Glu Ser Ser Leu Leu Met 
1               5                   10                  15


Arg Pro Arg Val Cys Pro Leu Arg Arg Ser Met Ile Thr Gly Leu Trp 
            20                  25                  30


Ala Trp Leu Ser Thr Met Trp Gln Ser Cys Ala Ser Ser Leu Leu Leu 
        35                  40                  45


Ser Pro 
    50


<210>  3180
<211>  750
<212>  DNA
<213>  Homo sapiens

<400>  3180
gcacaaagtg ctttgggggc aaagaaggga acacagttca ctgctggcgt gattgggtgg     60

acctcactga agaggtggca tttgaatact gaaggacaaa taggatttta tcagctagag    120

aaatagagga aggctacttc aggggcatag ggagcatcgt gtggctagaa aatacatgaa    180

agagagtaga tgaagagaaa gtgagtagtt cagcatggct ggagcgtggg gtaggtgtgg    240

ggctgggaga tgagcctagc tggacaggtg gatgggagca tgttgtgaag ggtctgtgtc    300

atatccagaa gtgttcaggc tataacttat agatattggg gagtggttgg aggtttttgg    360

ccactaaagc caggaggttt tagcaagatc accctggtgg tgtggaagta gagggtggat    420

gggaggaatt gttcaaggtg gggagactgc tctcctcctg ccgctccccg tcctgctcac    480

attttcgcat cctccctgtg ccaccatgag ctccctgccc gtgctccctg cccactctcc    540

cttagggttc tgcccatcct tactgcagtc ccggctacta ctctaccctg ttctgcctgt    600

gccctctctt cctttctagg cccgcctctg gctcctgggc ctgggcttta gtctgggcta    660

cggttccatg ttcaccaaga tttggtgggt ccacacggtc ttcacaaaga aggaagaaaa    720

gaaggagtgg aggaagactc tggaaccctg                                     750


<210>  3181
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  3181

Met Gly Gly Ile Val Gln Gly Gly Glu Thr Ala Leu Leu Leu Pro Leu 
1               5                   10                  15


Pro Val Leu Leu Thr Phe Ser His Pro Pro Cys Ala Thr Met Ser Ser 
            20                  25                  30


Leu Pro Val Leu Pro Ala His Ser Pro Leu Gly Phe Cys Pro Ser Leu 
        35                  40                  45


Leu Gln Ser Arg Leu Leu Leu Tyr Pro Val Leu Pro Val Pro Ser Leu 
    50                  55                  60


Pro Phe 
65


<210>  3182
<211>  563
<212>  DNA
<213>  Homo sapiens

<400>  3182
atgataatat ggatgcttgt atactcaagc acacctttac aggagcactg tgtctgggca     60

gaattgcatt tcattttctt ggtgatttat gttagtgttt tagagttgct taatattcac    120

tcatgattga tatgcaatta gcttggatcc tgttgctttt tttaatgatt ctttttttag    180

aattttatgt ggagaagggg cttttgaaat catttagccc cagacagctg gttaatgaca    240

gacttggagc gaggaggcgc attctctgat ttgagagggc tggggcagcc ctgcagctga    300

ggggcagaaa ccaggaaaat gagactcaga gtggtttaat gacttgtctc aggtcatgca    360

gctactcagc agtccagctg gaattgaatc ctagttaaat ctggctccaa actgctctgc    420

tcatcacttc ccatggaaaa ccatgaagcc tgactaaaaa gtttgtactt ttatctgcta    480

acactgttta gctactggca attgctgagc aaaggagaaa taagatttag gaagttgact    540

ctggtggtgt gttgtgatga aag                                            563


<210>  3183
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  3183

Met Ile Asp Met Gln Leu Ala Trp Ile Leu Leu Leu Phe Leu Met Ile 
1               5                   10                  15


Leu Phe Leu Glu Phe Tyr Val Glu Lys Gly Leu Leu Lys Ser Phe Ser 
            20                  25                  30


Pro Arg Gln Leu Val Asn Asp Arg Leu Gly Ala Arg Arg Arg Ile Leu 
        35                  40                  45


<210>  3184
<211>  3551
<212>  DNA
<213>  Homo sapiens

<400>  3184
agtgggcgca gggcccagct gggggaagcg gggctggggg agaggaggaa ccgcggggat     60

ggaatcgggg agcgctgagg cggccgatgc cgggagcgtg gatgttgctg ctgctgctac    120

tggcgccact cttcctccgc cccccgggcg cgggcggggc gcagaccccc aacgccacct    180

cagaaggttg ccagatcata cacccgccct gggaaggggg catcaggtac cggggcctga    240

ctcgggacca ggtgaaggct atcaacttcc tgccagtgga ctatgagatt gagtatgtgt    300

gccgggggga gcgcgaggtg gtggggccca aggtccgcaa gtgcctggcc aacggctcct    360

ggacagatat ggacacaccc agccgctgtg tccgaatctg ctccaagtct tatttgaccc    420

tggaaaatgg gaaggttttc ctgacgggtg gggacctccc agctctggac ggagcccggg    480

tggatttccg gtgtgacccc gacttccatc tggtgggcag ctcccggagc atctgtagtc    540

agggccagtg gagcaccccc aagccccact gccagggtga ggggaacagc tgcctgcatg    600

cagctgatga ggacgcttgt gtgaggatgg gagtggggtg ggaatggata atgggaaaga    660

atggagagct ataaaaatgt gggggaggac actggaaagg ggagatgaaa gtcccttttt    720

cctccatcac ctgcctcaaa cttcctcttg cagtccccgg tatcctctgt aggttggggg    780

cttccttcct ttacctttta aaaaaatctt cctgctcccg attcttagac ctcacgtttt    840

ctcttttcct ttatgaatct cacctctctc accttcttca ggtttaaata ctccaatttt    900

ccctttctct aaacttagaa atttccatgc atcaccctct tctagaattc atccctcacc    960

attccttata taattgattt attgtaaaga ctcagaaata aatcaaacat tctactaaga   1020

aaaattgaga aggggagctc tgggggtgga aacatattag ggtaaaagac ttaaaattgg   1080

aggcagcatt atcagaagat gaagaacaac tcagggatgg ggtgggaaga agacaggtcc   1140

ttttctgtac ttcctagaca acctccatta ttccctaagg gaatcagtgt tgtgtctgtc   1200

tacttttttt tttttttttt tgccacgtaa ttttacaaac tctccctttt ctaggcaccc   1260

gaactctctg ccatcttctc tcctgggatg cagtcatccc atttgtatgc ctcatacttc   1320

ctctaccctg gtagattctt tcaagatcct tgggctttac tttcctcaca taactcagtt   1380

attctgcttc tagtttacca ttttattctg gaaattgaga gtcccatcca ggggtggact   1440

tatgacacta ctgaaactta gacttcaagg ttcctcacct acagggccct cttcctgtgc   1500

tctaataata tagagggctc gatggatatg tgttcatatg gtaacaggct tttgtaaaaa   1560

ttgcagaaat aagattttaa cagcaattgc ttaaagccaa ttgtatgtgt aatttttttt   1620

cttaaagact cccaattttg taatattcag gcaccacaga accaagatct gccccaaact   1680

tagctattgg cattcccgtc tcaaattctg ttgtcctatg aaaaatcgaa gaagaaaata   1740

agtcctgacc cccttacccc cagacccacc ttgttcttat ccccaggcac cctcccctca   1800

gaaacgcagg cttctgctct ccccggtctt cagcatggac aggtgtggga gggggctggg   1860

gatcaggcca gggaagctgg gcgccagtgg taactcttct ctgatccccg tctttcctgc   1920

tgccagtgaa tcgaacgcca cactcaggtg agatgagaaa cccttaccgc gcgcactgca   1980

atgccctccc cttcactctg caccctccac ccccctgaaa ttctgccctt aggctacggg   2040

gcgtcgtcct ttcgcacctt ccccaaccca ccccagtttg cggccacccc cttccctccc   2100

tacctgtttc ctgcctccag tcccggtttt ccacgaggct gcggtctctc cttgtccctg   2160

cttggctaca cttccctggg ctccacctcc tcccagactg agcctcgccg gtgtcaggca   2220

gagcccagca gagggcggca gggtgctggg agaccctgag ctcccaccac gttttcccct   2280

gtggggttcc ttgcgacctt cgctggaacc ttttccagcc tgctgcctcc taggatttca   2340

cctaatggac tttctcagcc tgtcccaccc atcccaaccc tggccaggcc tctcgcgctc   2400

ttccccacat cttttccttc cgtgtacccc ttccctcgtc ttttctcaat tccatgtcct   2460

gtctcccttt cttaggcttc tgtctaccca gccccaggct cccttccacg accccaccac   2520

tccctcaaac cagcctccct tccgtaccca actcgttccc tccaaaaccg tttcctctcc   2580

cccacatcct cagtgcttca ctgtatcgac tcatactccc acttcagacc tcaggcgcca   2640

gccccgtttc tctcccgtcc cactcgcatc cttcccttcc taccctggtt cctccgtgct   2700

tcagcctccc gcggctccct ccgcccaccc cgccctcctg gcacgccccg tccccatttc   2760

tcctcccctc gggtcccctt aagtgagatc cctcccttcc tctttcgttc ctttcctcct   2820

cgaggttgca tcccccctcc cctccccgcc cctccgactg tcgctcccac ctcggcgctc   2880

gcttccctcc ccgccccctt cctgcctccc cagctcccgc ccgccccccc accccccgct   2940

gccgcgcgcc gcccgtgacg tcagagcccc ctcccagccc cacatctccc tcctgctcct   3000

cctcctcccc tccgtcggtc agtcagtccg cgaggagagt ccgcggtggc ggcgacggtg   3060

gcgagagccg cgggggccgt aggaagccaa ccttccctgc ttctccgggg ccctcgcccc   3120

ctcctcccca caaaatcagg gatggaggcg cctccccggc accctcttag cagccctccc   3180

caggaaaagt gtcccccctg agctcctaac gctccccaac agctacccct gccccccacg   3240

ccatggggcc cggggcccct tttgcccggg tggggtggcc actgccgctt ctggttgtga   3300

tggcggcagg ggtggctccg gtgtgggcct cccactcccc ccatctcccg cggcctcact   3360

cgcgggtccc cccgcacccc tcctcagaac ggcgcgcagt gtacatcggg gcactgtttc   3420

ccatgagcgg gggctggcca gggggccagg cctgccagcc cgcggtggag atggcgctgg   3480

aggacgtgaa tagccgcagg gacatcctgc cggactatga gctcaagctc atccaccacg   3540

acagcaaggt a                                                        3551


<210>  3185
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  3185

Met Pro Gly Ala Trp Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe 
1               5                   10                  15


Leu Arg Pro Pro Gly Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser 
            20                  25                  30


Glu Gly Cys Gln Ile Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr 
        35                  40                  45


Arg Gly Leu Thr Arg Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val 
    50                  55                  60


Asp Tyr Glu Ile Glu Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly 
65                  70                  75                  80


Pro Lys Val Arg Lys Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp 
                85                  90                  95


Thr Pro Ser Arg Cys Val Arg Ile Cys Ser Lys Ser Tyr Leu Thr Leu 
            100                 105                 110


Glu Asn Gly Lys Val Phe Leu Thr Gly Gly Asp Leu Pro Ala Leu Asp 
        115                 120                 125


Gly Ala Arg Val Asp Phe Arg Cys Asp Pro Asp Phe His Leu Val Gly 
    130                 135                 140


Ser Ser Arg Ser Ile Cys Ser Gln Gly Gln Trp Ser Thr Pro Lys Pro 
145                 150                 155                 160


His Cys Gln Gly Glu Gly Asn Ser Cys Leu His Ala Ala Asp Glu Asp 
                165                 170                 175


Ala Cys Val Arg Met Gly Val Gly Trp Glu Trp Ile Met Gly Lys Asn 
            180                 185                 190


Gly Glu Leu 
        195


<210>  3186
<211>  3786
<212>  DNA
<213>  Homo sapiens

<400>  3186
ccctctcttc cccccgccct gccttccctt gcaccctcct tcttccctcc gcccgggagc     60

tctccctggt ccccggcgcc gcctccttcc ctcccggctc cccgctcccc gctcccgtgg    120

ctgccgccgc cccggggaag aagagacagg ggtggggttt gggggaagcg agagaggagg    180

ggagagaccc tggccaggct ggagcctgga ttcgagggga ggagggacgg gaggaggaga    240

aaggtggagg agaagggagg ggggagcggg gaggagcggc cgggcctggg gccttgaggc    300

ccggggagag ccggggagcc gggcccgcgc gccgagatgt tgctgctgct gctactggcg    360

ccactcttcc tccgcccccc gggcgcgggc ggggcgcaga cccccaacgc cacctcagaa    420

ggttgccaga tcatacaccc gccctgggaa gggggcatca ggtaccgggg cctgactcgg    480

gaccaggtga aggctatcaa cttcctgcca gtggactatg agattgagta tgtgtgccgg    540

ggggagcgcg aggtggtggg gcccaaggtc cgcaagtgcc tggccaacgg ctcctggaca    600

gatatggaca cacccagccg ctgtgtccga atctgctcca agtcttattt gaccctggaa    660

aatgggaagg ttttcctgac gggtggggac ctcccagctc tggacggagc ccgggtggat    720

ttccggtgtg accccgactt ccatctggtg ggcagctccc ggagcatctg tagtcagggc    780

cagtggagca cccccaagcc ccactgccag ggtgagggga acagctgcct gcatgcagct    840

gatgaggacg cttgtgtgag gatgggagtg gggtgggaat ggataatggg aaagaatgga    900

gagctataaa aatgtggggg aggacactgg aaaggggaga tgaaagtccc tttttcctcc    960

atcacctgcc tcaaacttcc tcttgcagtc cccggtatcc tctgtaggtt gggggcttcc   1020

ttcctttacc ttttaaaaaa atcttcctgc tcccgattct tagacctcac gttttctctt   1080

ttcctttatg aatctcacct ctctcacctt cttcaggttt aaatactcca attttccctt   1140

tctctaaact tagaaatttc catgcatcac cctcttctag aattcatccc tcaccattcc   1200

ttatataatt gatttattgt aaagactcag aaataaatca aacattctac taagaaaaat   1260

tgagaagggg agctctgggg gtggaaacat attagggtaa aagacttaaa attggaggca   1320

gcattatcag aagatgaaga acaactcagg gatggggtgg gaagaagaca ggtccttttc   1380

tgtacttcct agacaacctc cattattccc taagggaatc agtgttgtgt ctgtctactt   1440

tttttttttt ttttttgcca cgtaatttta caaactctcc cttttctagg cacccgaact   1500

ctctgccatc ttctctcctg ggatgcagtc atcccatttg tatgcctcat acttcctcta   1560

ccctggtaga ttctttcaag atccttgggc tttactttcc tcacataact cagttattct   1620

gcttctagtt taccatttta ttctggaaat tgagagtccc atccaggggt ggacttatga   1680

cactactgaa acttagactt caaggttcct cacctacagg gccctcttcc tgtgctctaa   1740

taatatagag ggctcgatgg atatgtgttc atatggtaac aggcttttgt aaaaattgca   1800

gaaataagat tttaacagca attgcttaaa gccaattgta tgtgtaattt tttttcttaa   1860

agactcccaa ttttgtaata ttcaggcacc acagaaccaa gatctgcccc aaacttagct   1920

attggcattc ccgtctcaaa ttctgttgtc ctatgaaaaa tcgaagaaga aaataagtcc   1980

tgaccccctt acccccagac ccaccttgtt cttatcccca ggcaccctcc cctcagaaac   2040

gcaggcttct gctctccccg gtcttcagca tggacaggtg tgggaggggg ctggggatca   2100

ggccagggaa gctgggcgcc agtggtaact cttctctgat ccccgtcttt cctgctgcca   2160

gtgaatcgaa cgccacactc aggtgagatg agaaaccctt accgcgcgca ctgcaatgcc   2220

ctccccttca ctctgcaccc tccacccccc tgaaattctg cccttaggct acggggcgtc   2280

gtcctttcgc accttcccca acccacccca gtttgcggcc acccccttcc ctccctacct   2340

gtttcctgcc tccagtcccg gttttccacg aggctgcggt ctctccttgt ccctgcttgg   2400

ctacacttcc ctgggctcca cctcctccca gactgagcct cgccggtgtc aggcagagcc   2460

cagcagaggg cggcagggtg ctgggagacc ctgagctccc accacgtttt cccctgtggg   2520

gttccttgcg accttcgctg gaaccttttc cagcctgctg cctcctagga tttcacctaa   2580

tggactttct cagcctgtcc cacccatccc aaccctggcc aggcctctcg cgctcttccc   2640

cacatctttt ccttccgtgt accccttccc tcgtcttttc tcaattccat gtcctgtctc   2700

cctttcttag gcttctgtct acccagcccc aggctccctt ccacgacccc accactccct   2760

caaaccagcc tcccttccgt acccaactcg ttccctccaa aaccgtttcc tctcccccac   2820

atcctcagtg cttcactgta tcgactcata ctcccacttc agacctcagg cgccagcccc   2880

gtttctctcc cgtcccactc gcatccttcc cttcctaccc tggttcctcc gtgcttcagc   2940

ctcccgcggc tccctccgcc caccccgccc tcctggcacg ccccgtcccc atttctcctc   3000

ccctcgggtc cccttaagtg agatccctcc cttcctcttt cgttcctttc ctcctcgagg   3060

ttgcatcccc cctcccctcc ccgcccctcc gactgtcgct cccacctcgg cgctcgcttc   3120

cctccccgcc cccttcctgc ctccccagct cccgcccgcc cccccacccc ccgctgccgc   3180

gcgccgcccg tgacgtcaga gccccctccc agccccacat ctccctcctg ctcctcctcc   3240

tcccctccgt cggtcagtca gtccgcgagg agagtccgcg gtggcggcga cggtggcgag   3300

agccgcgggg gccgtaggaa gccaaccttc cctgcttctc cggggccctc gccccctcct   3360

ccccacaaaa tcagggatgg aggcgcctcc ccggcaccct cttagcagcc ctccccagga   3420

aaagtgtccc ccctgagctc ctaacgctcc ccaacagcta cccctgcccc ccacgccatg   3480

gggcccgggg ccccttttgc ccgggtgggg tggccactgc cgcttctggt tgtgatggcg   3540

gcaggggtgg ctccggtgtg ggcctcccac tccccccatc tcccgcggcc tcactcgcgg   3600

gtccccccgc acccctcctc agaacggcgc gcagtgtaca tcggggcact gtttcccatg   3660

agcgggggct ggccaggggg ccaggcctgc cagcccgcgg tggagatggc gctggaggac   3720

gtgaatagcc gcagggacat cctgccggac tatgagctca agctcatcca ccacgacagc   3780

aaggta                                                              3786


<210>  3187
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  3187

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
1               5                   10                  15


Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
            20                  25                  30


Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
        35                  40                  45


Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
    50                  55                  60


Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
65                  70                  75                  80


Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                85                  90                  95


Val Arg Ile Cys Ser Lys Ser Tyr Leu Thr Leu Glu Asn Gly Lys Val 
            100                 105                 110


Phe Leu Thr Gly Gly Asp Leu Pro Ala Leu Asp Gly Ala Arg Val Asp 
        115                 120                 125


Phe Arg Cys Asp Pro Asp Phe His Leu Val Gly Ser Ser Arg Ser Ile 
    130                 135                 140


Cys Ser Gln Gly Gln Trp Ser Thr Pro Lys Pro His Cys Gln Gly Glu 
145                 150                 155                 160


Gly Asn Ser Cys Leu His Ala Ala Asp Glu Asp Ala Cys Val Arg Met 
                165                 170                 175


Gly Val Gly Trp Glu Trp Ile Met Gly Lys Asn Gly Glu Leu 
            180                 185                 190


<210>  3188
<211>  971
<212>  DNA
<213>  Homo sapiens

<400>  3188
gggagagcac gacgtgcgcg caccctctcc ccttgtccac tgctgccgcc tccttcttct     60

gccgctcctg gtgctgcttg tgtgctcgtt tggagcggac ctggtacctc ttttgtgaag    120

cggcagctga ggagactccg gcgctcgcca tggccgaaga aaagcccaag gaaggagtca    180

agactgagaa caacgatcat attaatttga aggtggcggg gcaggatggt tctgtggtgc    240

agtttaagat taagaggcat acaccactta gtaaactaat gaaagcctat tgtgaacgac    300

agttggaaat ggaggatgaa gatacaattg atgtgttcca acagcagacg ggaggtgtct    360

actgaaaagg gaacctgctt ctttactcca gaactctgtt ctttaaagac caagattaca    420

ttctcaatta gaaaactgca atttgcttcc accacatcct gactactacc gtatagtttt    480

ctctattctt tcatttcccc cttccccatt cctttactgt acataaagta actggtatat    540

gtgcacaagc atattacttt ttttttttaa aactaaacag ccaatggtat gttttgattg    600

acatcaagtg gagacggggc ggaaaaatac tgattctgtg aaaatacccc ctttctccat    660

tagtggcatg ctcattcagc tcttatcttt atattccagt aagttatttt gctctcactg    720

ttttaacaac aacaacaaaa aaacaacaac ataaaaatcc ttgcatacct tgttcaattg    780

gagaatttta atgtttttca tttatcattg taaaaccaag gacaatttta taactttttt    840

gtacttagct gttacatgca gagcaatctg tctttaagta gggataaatt actctaaaac    900

aaaaaagaat cctagatagt tttcccttca agtcaagcgt cttgttgttt aaataaactt    960

cttgtttaaa a                                                         971


<210>  3189
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  3189

Met Ala Glu Glu Lys Pro Lys Glu Gly Val Lys Thr Glu Asn Asn Asp 
1               5                   10                  15


His Ile Asn Leu Lys Val Ala Gly Gln Asp Gly Ser Val Val Gln Phe 
            20                  25                  30


Lys Ile Lys Arg His Thr Pro Leu Ser Lys Leu Met Lys Ala Tyr Cys 
        35                  40                  45


Glu Arg Gln Leu Glu Met Glu Asp Glu Asp Thr Ile Asp Val Phe Gln 
    50                  55                  60


Gln Gln Thr Gly Gly Val Tyr 
65                  70


<210>  3190
<211>  2037
<212>  DNA
<213>  Homo sapiens

<400>  3190
tcagtctgta gcccttttgt gtgagtgcct ggcaagggtg acgtggggct gtttctgcgg     60

gcacagctgc agcaattacc ggagtggagg cagggcccag gcagcactgc cctccaagat    120

cttcccttgg gcttttcagc agtaagggga catgcacccc aagggcctcc acttggcctg    180

accttgctgc gggggctctc tgtccccagg aacagtagag atggcaagct tatcaagacc    240

ctctctgccc agctgcctct gctccttcct cctcctcctc ctcctccaag tgtcttccag    300

ctatgcaggg cagttcagag tgataggacc aagacaccct atccgggctc tggtcgggga    360

tgaagtggaa ttgccatgtc gcatatctcc tgggaagaac gctacaggca tggaggtggg    420

gtggtaccgc ccccccttct ctagggtggt tcatctctac agaaatggca aggaccaaga    480

tggagaccag gcacctgaat atcggggccg gacagagctg ctgaaagatg ctattggtga    540

gggaaaggtg actctcagga tccggaatgt aaggttctca gatgaaggag gtttcacctg    600

cttcttccga gatcattctt accaagagga ggcagcaatg gaattgaaag tagaagtgtc    660

tcactctgtc acccaggatt ggttgcagtg gcacgatcat ggctcattgc agcctccacc    720

tcccaggctc aagtgatcct cctgactcag cctcttgaat agctgagacc acaggcttgt    780

gtcaccatgc ccagatcctt tctactgggt gagccctgga gtgctggttc tcctcgcggt    840

gctgcctgtg ctcctcctgc agatcactgt tggcctcatc ttcctctgcc tgcagtacag    900

actgagagga aaacttcgag cagagataga gaatctccac cggacttttg atccccactt    960

tctgagggtg ccctgctgga agataaccct gtttgtaatt gtgccggttc ttggaccctt   1020

ggttgccttg atcatctgct acaactggct acatcgaaga ctagcagggc aattccttga   1080

agagctactc ttccacctgg aagccctctc tggctaagga caggcaggtg cccctctctc   1140

catcagagga cacctgtact ggagagcaac acaggatggt ctctgccatg aactggaggc   1200

caggaatctc ctcactgaaa attacagtat ggtaactttg caaatggtgg ttgtttcttc   1260

caagactcca gccctgattg cgcaaaactg aaaggcatgt gaagggaagg aagaggaaga   1320

gtgcaaaaca ttgaagagag agctgagtga gctgaagagt gaggatatga gtagccccaa   1380

cccaaacctg gagatgggga gaaacctaca gaatactagc cagagctcct ccttgtcttg   1440

gcagcctact agggacctgg ggaagcaaaa acgaaagctg ggcaacatgc ctgctttaga   1500

atgttttcct tctacttaca catcttccac aggtctcaga atctttcctt cctctcatcc   1560

ttttctccta tcttcatatc tatcagagta tccactgttt attcaacaac tactacttga   1620

tggtcagaca caaacaaaca agctaggtgc taattaataa agatacgagt tttggccggg   1680

tgcggtggct cacgcctgta atcccagcac tttgggaggc cgaggcgggc gaatcacgag   1740

gtcaggagtt caagaccagc ctggccaaca tggtgaaacc ccatctctac taaaaataca   1800

aacaattaac tgagcatagt ggtgggcacc tataatacca gctactccgg aggctgaggc   1860

aggagaatcg cttgaaccca ggaggcagag gttgcagtga gctgagatcg tgccactgca   1920

ctctagccgg agtgacagag taagactctg tctcaaaaat aaataaataa ataaataaat   1980

aaataaataa ataaataaat aaaaaataat aatacaagtt ttcataagca cacttct      2037


<210>  3191
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  3191

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140


Glu Val Ser His Ser Val Thr Gln Asp Trp Leu Gln Trp His Asp His 
145                 150                 155                 160


Gly Ser Leu Gln Pro Pro Pro Pro Arg Leu Lys 
                165                 170


<210>  3192
<211>  2080
<212>  DNA
<213>  Homo sapiens

<400>  3192
tcagtctgta gcccttttgt gtgagtgcct ggcaagggtg acgtggggct gtttctgcgg     60

gcacagctgc agcaattacc ggagtggagg cagggcccag gcagcactgc cctccaagat    120

cttcccttgg gcttttcagc agtaagggga catgcacccc aagggcctcc acttggcctg    180

accttgctgc gggggctctc tgtccccagg aacagtagag atggcaagct tatcaagacc    240

ctctctgccc agctgcctct gctccttcct cctcctcctc ctcctccaag tgtcttccag    300

ctatgcaggg cagttcagag tgataggacc aagacaccct atccgggctc tggtcgggga    360

tgaagtggaa ttgccatgtc gcatatctcc tgggaagaac gctacaggca tggaggtggg    420

gtggtaccgc ccccccttct ctagggtggt tcatctctac agaaatggca aggaccaaga    480

tggagaccag gcacctgaat atcggggccg gacagagctg ctgaaagatg ctattggtga    540

gggaaaggtg actctcagga tccggaatgt aaggttctca gatgaaggag gtttcacctg    600

cttcttccga gatcattctt accaagagga ggcagcaatg gaattgaaag tagaagatcc    660

tttctactgg gtgagccctg gagtgctggt tctcctcgcg gtgctgcctg tgctcctcct    720

gcagatcact gttggcctca tcttcctctg cctgcagtac agactgagag gaaaacttcg    780

agcagagata gagaatctcc accggacttt tgagtccttt ggtgttctag gaccccaggt    840

taaggaacca aaaaagacag ggcaattcct tgaagagcta cgaaatccct tctgagtgat    900

gtcacatctt ggcaggggtg gaggagagcc tggttgccca gggatttgtc cttggggaca    960

tctcatccat caagttgcac actcactggc atctttgcta tggggacatt ccaatttgca   1020

ctttcaggaa cactctgaat tccaagtaga attgatttcc cttcttctgt catctacctt   1080

ttctcttcat tttcccattt ttattaccct tctttccatt tctctctcca gtcttccacc   1140

tggaagccct ctctggctaa ggacaggcag gtgcccctct ctccatcaga ggacacctgt   1200

actggagagc aacacaggat ggtctctgcc atgaactgga ggccaggaat ctcctcactg   1260

aaaattacag tatggtaact ttgcaaatgg tggttgtttc ttccaagact ccagccctga   1320

ttgcgcaaaa ctgaaaggca tgtgaaggga aggaagagga agagtgcaaa acattgaaga   1380

gagagctgag tgagctgaag agtgaggata tgagtagccc caacccaaac ctggagatgg   1440

ggagaaacct acagaatact agccagagct cctccttgtc ttggcagcct actagggacc   1500

tggggaagca aaaacgaaag ctgggcaaca tgcctgcttt agaatgtttt ccttctactt   1560

acacatcttc cacaggtctc agaatctttc cttcctctca tccttttctc ctatcttcat   1620

atctatcaga gtatccactg tttattcaac aactactact tgatggtcag acacaaacaa   1680

acaagctagg tgctaattaa taaagatacg agttttggcc gggtgcggtg gctcacgcct   1740

gtaatcccag cactttggga ggccgaggcg ggcgaatcac gaggtcagga gttcaagacc   1800

agcctggcca acatggtgaa accccatctc tactaaaaat acaaacaatt aactgagcat   1860

agtggtgggc acctataata ccagctactc cggaggctga ggcaggagaa tcgcttgaac   1920

ccaggaggca gaggttgcag tgagctgaga tcgtgccact gcactctagc cggagtgaca   1980

gagtaagact ctgtctcaaa aataaataaa taaataaata aataaataaa taaataaata   2040

aataaaaaat aataatacaa gttttcataa gcacacttct                         2080


<210>  3193
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  3193

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190


Leu His Arg Thr Phe Glu Ser Phe Gly Val Leu Gly Pro Gln Val Lys 
        195                 200                 205


Glu Pro Lys Lys Thr Gly Gln Phe Leu Glu Glu Leu Arg Asn Pro Phe 
    210                 215                 220


<210>  3194
<211>  1761
<212>  DNA
<213>  Homo sapiens

<400>  3194
tcagtctgta gcccttttgt gtgagtgcct ggcaagggtg acgtggggct gtttctgcgg     60

gcacagctgc agcaattacc ggagtggagg cagggcccag gcagcactgc cctccaagat    120

cttcccttgg gcttttcagc agtaagggga catgcacccc aagggcctcc acttggcctg    180

accttgctgc gggggctctc tgtccccagg aacagtagag atggcaagct tatcaagacc    240

ctctctgccc agctgcctct gctccttcct cctcctcctc ctcctccaag tgtcttccag    300

ctatgcaggg cagttcagag tgataggacc aagacaccct atccgggctc tggtcgggga    360

tgaagtggaa ttgccatgtc gcatatctcc tgggaagaac gctacaggca tggaggtggg    420

gtggtaccgc ccccccttct ctagggtggt tcatctctac agaaatggca aggaccaaga    480

tggagaccag gcacctgaat atcggggccg gacagagctg ctgaaagatg ctattggtga    540

gggaaaggtg actctcagga tccggaatgt aaggttctca gatgaaggag gtttcacctg    600

cttcttccga gatcattctt accaagagga ggcagcaatg gaattgaaag tagaagatcc    660

tttctactgg gtgagccctg gagtgctggt tctcctcgcg gtgctgcctg tgctcctcct    720

gcagatcact gttggcctca tcttcctctg cctgcagtac agactgagag gaaaacttcg    780

agcagagata gagaatctcc accggacttt tgtcttccac ctggaagccc tctctggcta    840

aggacaggca ggtgcccctc tctccatcag aggacacctg tactggagag caacacagga    900

tggtctctgc catgaactgg aggccaggaa tctcctcact gaaaattaca gtatggtaac    960

tttgcaaatg gtggttgttt cttccaagac tccagccctg attgcgcaaa actgaaaggc   1020

atgtgaaggg aaggaagagg aagagtgcaa aacattgaag agagagctga gtgagctgaa   1080

gagtgaggat atgagtagcc ccaacccaaa cctggagatg gggagaaacc tacagaatac   1140

tagccagagc tcctccttgt cttggcagcc tactagggac ctggggaagc aaaaacgaaa   1200

gctgggcaac atgcctgctt tagaatgttt tccttctact tacacatctt ccacaggtct   1260

cagaatcttt ccttcctctc atccttttct cctatcttca tatctatcag agtatccact   1320

gtttattcaa caactactac ttgatggtca gacacaaaca aacaagctag gtgctaatta   1380

ataaagatac gagttttggc cgggtgcggt ggctcacgcc tgtaatccca gcactttggg   1440

aggccgaggc gggcgaatca cgaggtcagg agttcaagac cagcctggcc aacatggtga   1500

aaccccatct ctactaaaaa tacaaacaat taactgagca tagtggtggg cacctataat   1560

accagctact ccggaggctg aggcaggaga atcgcttgaa cccaggaggc agaggttgca   1620

gtgagctgag atcgtgccac tgcactctag ccggagtgac agagtaagac tctgtctcaa   1680

aaataaataa ataaataaat aaataaataa ataaataaat aaataaaaaa taataataca   1740

agttttcata agcacacttc t                                             1761


<210>  3195
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  3195

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190


Leu His Arg Thr Phe Val Phe His Leu Glu Ala Leu Ser Gly 
        195                 200                 205


<210>  3196
<211>  1899
<212>  DNA
<213>  Homo sapiens

<400>  3196
tcagtctgta gcccttttgt gtgagtgcct ggcaagggtg acgtggggct gtttctgcgg     60

gcacagctgc agcaattacc ggagtggagg cagggcccag gcagcactgc cctccaagat    120

cttcccttgg gcttttcagc agtaagggga catgcacccc aagggcctcc acttggcctg    180

accttgctgc gggggctctc tgtccccagg aacagtagag atggcaagct tatcaagacc    240

ctctctgccc agctgcctct gctccttcct cctcctcctc ctcctccaag tgtcttccag    300

ctatgcaggg cagttcagag tgataggacc aagacaccct atccgggctc tggtcgggga    360

tgaagtggaa ttgccatgtc gcatatctcc tgggaagaac gctacaggca tggaggtggg    420

gtggtaccgc ccccccttct ctagggtggt tcatctctac agaaatggca aggaccaaga    480

tggagaccag gcacctgaat atcggggccg gacagagctg ctgaaagatg ctattggtga    540

gggaaaggtg actctcagga tccggaatgt aaggttctca gatgaaggag gtttcacctg    600

cttcttccga gatcattctt accaagagga ggcagcaatg gaattgaaag tagaagatcc    660

tttctactgg gtgagccctg gagtgctggt tctcctcgcg gtgctgcctg tgctcctcct    720

gcagatcact gttggcctca tcttcctctg cctgcagtac agactgagag gaaaacttcg    780

agcagagata gagaatctcc accggacttt tgatccccac tttctgaggg tgccctgctg    840

gaagataacc ctgtttgtaa ttgtgccggt tcttggaccc ttggttgcct tgatcatctg    900

ctacaactgg ctacatcgaa gactagcagg gcaattcctt gaagagctac tcttccacct    960

ggaagccctc tctggctaag gacaggcagg tgcccctctc tccatcagag gacacctgta   1020

ctggagagca acacaggatg gtctctgcca tgaactggag gccaggaatc tcctcactga   1080

aaattacagt atggtaactt tgcaaatggt ggttgtttct tccaagactc cagccctgat   1140

tgcgcaaaac tgaaaggcat gtgaagggaa ggaagaggaa gagtgcaaaa cattgaagag   1200

agagctgagt gagctgaaga gtgaggatat gagtagcccc aacccaaacc tggagatggg   1260

gagaaaccta cagaatacta gccagagctc ctccttgtct tggcagccta ctagggacct   1320

ggggaagcaa aaacgaaagc tgggcaacat gcctgcttta gaatgttttc cttctactta   1380

cacatcttcc acaggtctca gaatctttcc ttcctctcat ccttttctcc tatcttcata   1440

tctatcagag tatccactgt ttattcaaca actactactt gatggtcaga cacaaacaaa   1500

caagctaggt gctaattaat aaagatacga gttttggccg ggtgcggtgg ctcacgcctg   1560

taatcccagc actttgggag gccgaggcgg gcgaatcacg aggtcaggag ttcaagacca   1620

gcctggccaa catggtgaaa ccccatctct actaaaaata caaacaatta actgagcata   1680

gtggtgggca cctataatac cagctactcc ggaggctgag gcaggagaat cgcttgaacc   1740

caggaggcag aggttgcagt gagctgagat cgtgccactg cactctagcc ggagtgacag   1800

agtaagactc tgtctcaaaa ataaataaat aaataaataa ataaataaat aaataaataa   1860

ataaaaaata ataatacaag ttttcataag cacacttct                          1899


<210>  3197
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  3197

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190


Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys 
        195                 200                 205


Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu 
    210                 215                 220


Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu 
225                 230                 235                 240


Glu Glu Leu Leu Phe His Leu Glu Ala Leu Ser Gly 
                245                 250


<210>  3198
<211>  2287
<212>  DNA
<213>  Homo sapiens

<400>  3198
tcagtctgta gcccttttgt gtgagtgcct ggcaagggtg acgtggggct gtttctgcgg     60

gcacagctgc agcaattacc ggagtggagg cagggcccag gcagcactgc cctccaagat    120

cttcccttgg gcttttcagc agtaagggga catgcacccc aagggcctcc acttggcctg    180

accttgctgc gggggctctc tgtccccagg aacagtagag atggcaagct tatcaagacc    240

ctctctgccc agctgcctct gctccttcct cctcctcctc ctcctccaag tgtcttccag    300

ctatgcaggg cagttcagag tgataggacc aagacaccct atccgggctc tggtcgggga    360

tgaagtggaa ttgccatgtc gcatatctcc tgggaagaac gctacaggca tggaggtggg    420

gtggtaccgc ccccccttct ctagggtggt tcatctctac agaaatggca aggaccaaga    480

tggagaccag gcacctgaat atcggggccg gacagagctg ctgaaagatg ctattggtga    540

gggaaaggtg actctcagga tccggaatgt aaggttctca gatgaaggag gtttcacctg    600

cttcttccga gatcattctt accaagagga ggcagcaatg gaattgaaag tagaagtgtc    660

tcactctgtc acccaggatt ggttgcagtg gcacgatcat ggctcattgc agcctccacc    720

tcccaggctc aagtgatcct cctgactcag cctcttgaat agctgagacc acaggcttgt    780

gtcaccatgc ccagatcctt tctactgggt gagccctgga gtgctggttc tcctcgcggt    840

gctgcctgtg ctcctcctgc agatcactgt tggcctcatc ttcctctgcc tgcagtacag    900

actgagagga aaacttcgag cagagataga gaatctccac cggacttttg atccccactt    960

tctgagggtg ccctgctgga agataaccct gtttgtaatt gtgccggttc ttggaccctt   1020

ggttgccttg atcatctgct acaactggct acatcgaaga ctagcagggc aattccttga   1080

agagctacga aatcccttct gagtgatgtc acatcttggc aggggtggag gagagcctgg   1140

ttgcccaggg atttgtcctt ggggacatct catccatcaa gttgcacact cactggcatc   1200

tttgctatgg ggacattcca atttgcactt tcaggaacac tctgaattcc aagtagaatt   1260

gatttccctt cttctgtcat ctaccttttc tcttcatttt cccattttta ttacccttct   1320

ttccatttct ctctccagtc ttccacctgg aagccctctc tggctaagga caggcaggtg   1380

cccctctctc catcagagga cacctgtact ggagagcaac acaggatggt ctctgccatg   1440

aactggaggc caggaatctc ctcactgaaa attacagtat ggtaactttg caaatggtgg   1500

ttgtttcttc caagactcca gccctgattg cgcaaaactg aaaggcatgt gaagggaagg   1560

aagaggaaga gtgcaaaaca ttgaagagag agctgagtga gctgaagagt gaggatatga   1620

gtagccccaa cccaaacctg gagatgggga gaaacctaca gaatactagc cagagctcct   1680

ccttgtcttg gcagcctact agggacctgg ggaagcaaaa acgaaagctg ggcaacatgc   1740

ctgctttaga atgttttcct tctacttaca catcttccac aggtctcaga atctttcctt   1800

cctctcatcc ttttctccta tcttcatatc tatcagagta tccactgttt attcaacaac   1860

tactacttga tggtcagaca caaacaaaca agctaggtgc taattaataa agatacgagt   1920

tttggccggg tgcggtggct cacgcctgta atcccagcac tttgggaggc cgaggcgggc   1980

gaatcacgag gtcaggagtt caagaccagc ctggccaaca tggtgaaacc ccatctctac   2040

taaaaataca aacaattaac tgagcatagt ggtgggcacc tataatacca gctactccgg   2100

aggctgaggc aggagaatcg cttgaaccca ggaggcagag gttgcagtga gctgagatcg   2160

tgccactgca ctctagccgg agtgacagag taagactctg tctcaaaaat aaataaataa   2220

ataaataaat aaataaataa ataaataaat aaaaaataat aatacaagtt ttcataagca   2280

cacttct                                                             2287


<210>  3199
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  3199

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140


Glu Val Ser His Ser Val Thr Gln Asp Trp Leu Gln Trp His Asp His 
145                 150                 155                 160


Gly Ser Leu Gln Pro Pro Pro Pro Arg Leu Lys 
                165                 170


<210>  3200
<211>  2149
<212>  DNA
<213>  Homo sapiens

<400>  3200
tcagtctgta gcccttttgt gtgagtgcct ggcaagggtg acgtggggct gtttctgcgg     60

gcacagctgc agcaattacc ggagtggagg cagggcccag gcagcactgc cctccaagat    120

cttcccttgg gcttttcagc agtaagggga catgcacccc aagggcctcc acttggcctg    180

accttgctgc gggggctctc tgtccccagg aacagtagag atggcaagct tatcaagacc    240

ctctctgccc agctgcctct gctccttcct cctcctcctc ctcctccaag tgtcttccag    300

ctatgcaggg cagttcagag tgataggacc aagacaccct atccgggctc tggtcgggga    360

tgaagtggaa ttgccatgtc gcatatctcc tgggaagaac gctacaggca tggaggtggg    420

gtggtaccgc ccccccttct ctagggtggt tcatctctac agaaatggca aggaccaaga    480

tggagaccag gcacctgaat atcggggccg gacagagctg ctgaaagatg ctattggtga    540

gggaaaggtg actctcagga tccggaatgt aaggttctca gatgaaggag gtttcacctg    600

cttcttccga gatcattctt accaagagga ggcagcaatg gaattgaaag tagaagatcc    660

tttctactgg gtgagccctg gagtgctggt tctcctcgcg gtgctgcctg tgctcctcct    720

gcagatcact gttggcctca tcttcctctg cctgcagtac agactgagag gaaaacttcg    780

agcagagata gagaatctcc accggacttt tgatccccac tttctgaggg tgccctgctg    840

gaagataacc ctgtttgtaa ttgtgccggt tcttggaccc ttggttgcct tgatcatctg    900

ctacaactgg ctacatcgaa gactagcagg gcaattcctt gaagagctac gaaatccctt    960

ctgagtgatg tcacatcttg gcaggggtgg aggagagcct ggttgcccag ggatttgtcc   1020

ttggggacat ctcatccatc aagttgcaca ctcactggca tctttgctat ggggacattc   1080

caatttgcac tttcaggaac actctgaatt ccaagtagaa ttgatttccc ttcttctgtc   1140

atctaccttt tctcttcatt ttcccatttt tattaccctt ctttccattt ctctctccag   1200

tcttccacct ggaagccctc tctggctaag gacaggcagg tgcccctctc tccatcagag   1260

gacacctgta ctggagagca acacaggatg gtctctgcca tgaactggag gccaggaatc   1320

tcctcactga aaattacagt atggtaactt tgcaaatggt ggttgtttct tccaagactc   1380

cagccctgat tgcgcaaaac tgaaaggcat gtgaagggaa ggaagaggaa gagtgcaaaa   1440

cattgaagag agagctgagt gagctgaaga gtgaggatat gagtagcccc aacccaaacc   1500

tggagatggg gagaaaccta cagaatacta gccagagctc ctccttgtct tggcagccta   1560

ctagggacct ggggaagcaa aaacgaaagc tgggcaacat gcctgcttta gaatgttttc   1620

cttctactta cacatcttcc acaggtctca gaatctttcc ttcctctcat ccttttctcc   1680

tatcttcata tctatcagag tatccactgt ttattcaaca actactactt gatggtcaga   1740

cacaaacaaa caagctaggt gctaattaat aaagatacga gttttggccg ggtgcggtgg   1800

ctcacgcctg taatcccagc actttgggag gccgaggcgg gcgaatcacg aggtcaggag   1860

ttcaagacca gcctggccaa catggtgaaa ccccatctct actaaaaata caaacaatta   1920

actgagcata gtggtgggca cctataatac cagctactcc ggaggctgag gcaggagaat   1980

cgcttgaacc caggaggcag aggttgcagt gagctgagat cgtgccactg cactctagcc   2040

ggagtgacag agtaagactc tgtctcaaaa ataaataaat aaataaataa ataaataaat   2100

aaataaataa ataaaaaata ataatacaag ttttcataag cacacttct               2149


<210>  3201
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  3201

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190


Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys 
        195                 200                 205


Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu 
    210                 215                 220


Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu 
225                 230                 235                 240


Glu Glu Leu Arg Asn Pro Phe 
                245


<210>  3202
<211>  2032
<212>  DNA
<213>  Homo sapiens

<400>  3202
tcagtctgta gcccttttgt gtgagtgcct ggcaagggtg acgtggggct gtttctgcgg     60

gcacagctgc agcaattacc ggagtggagg cagggcccag gcagcactgc cctccaagat    120

cttcccttgg gcttttcagc agtaagggga catgcacccc aagggcctcc acttggcctg    180

accttgctgc gggggctctc tgtccccagg aacagtagag atggcaagct tatcaagacc    240

ctctctgccc agctgcctct gctccttcct cctcctcctc ctcctccaag tgtcttccag    300

ctatgcaggg cagttcagag tgataggacc aagacaccct atccgggctc tggtcgggga    360

tgaagtggaa ttgccatgtc gcatatctcc tgggaagaac gctacaggca tggaggtggg    420

gtggtaccgc ccccccttct ctagggtggt tcatctctac agaaatggca aggaccaaga    480

tggagaccag gcacctgaat atcggggccg gacagagctg ctgaaagatg ctattggtga    540

gggaaaggtg actctcagga tccggaatgt aaggttctca gatgaaggag gtttcacctg    600

cttcttccga gatcattctt accaagagga ggcagcaatg gaattgaaag tagaagatcc    660

tttctactgg gtgagccctg gagtgctggt tctcctcgcg gtgctgcctg tgctcctcct    720

gcagatcact gttggcctca tcttcctctg cctgcagtac agactgagag gaaaacttcg    780

agcagagata gagaatctcc accggacttt tgggcaattc cttgaagagc tacgaaatcc    840

cttctgagtg atgtcacatc ttggcagggg tggaggagag cctggttgcc cagggatttg    900

tccttgggga catctcatcc atcaagttgc acactcactg gcatctttgc tatggggaca    960

ttccaatttg cactttcagg aacactctga attccaagta gaattgattt cccttcttct   1020

gtcatctacc ttttctcttc attttcccat ttttattacc cttctttcca tttctctctc   1080

cagtcttcca cctggaagcc ctctctggct aaggacaggc aggtgcccct ctctccatca   1140

gaggacacct gtactggaga gcaacacagg atggtctctg ccatgaactg gaggccagga   1200

atctcctcac tgaaaattac agtatggtaa ctttgcaaat ggtggttgtt tcttccaaga   1260

ctccagccct gattgcgcaa aactgaaagg catgtgaagg gaaggaagag gaagagtgca   1320

aaacattgaa gagagagctg agtgagctga agagtgagga tatgagtagc cccaacccaa   1380

acctggagat ggggagaaac ctacagaata ctagccagag ctcctccttg tcttggcagc   1440

ctactaggga cctggggaag caaaaacgaa agctgggcaa catgcctgct ttagaatgtt   1500

ttccttctac ttacacatct tccacaggtc tcagaatctt tccttcctct catccttttc   1560

tcctatcttc atatctatca gagtatccac tgtttattca acaactacta cttgatggtc   1620

agacacaaac aaacaagcta ggtgctaatt aataaagata cgagttttgg ccgggtgcgg   1680

tggctcacgc ctgtaatccc agcactttgg gaggccgagg cgggcgaatc acgaggtcag   1740

gagttcaaga ccagcctggc caacatggtg aaaccccatc tctactaaaa atacaaacaa   1800

ttaactgagc atagtggtgg gcacctataa taccagctac tccggaggct gaggcaggag   1860

aatcgcttga acccaggagg cagaggttgc agtgagctga gatcgtgcca ctgcactcta   1920

gccggagtga cagagtaaga ctctgtctca aaaataaata aataaataaa taaataaata   1980

aataaataaa taaataaaaa ataataatac aagttttcat aagcacactt ct           2032


<210>  3203
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  3203

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190


Leu His Arg Thr Phe Gly Gln Phe Leu Glu Glu Leu Arg Asn Pro Phe 
        195                 200                 205


<210>  3204
<211>  1782
<212>  DNA
<213>  Homo sapiens

<400>  3204
tcagtctgta gcccttttgt gtgagtgcct ggcaagggtg acgtggggct gtttctgcgg     60

gcacagctgc agcaattacc ggagtggagg cagggcccag gcagcactgc cctccaagat    120

cttcccttgg gcttttcagc agtaagggga catgcacccc aagggcctcc acttggcctg    180

accttgctgc gggggctctc tgtccccagg aacagtagag atggcaagct tatcaagacc    240

ctctctgccc agctgcctct gctccttcct cctcctcctc ctcctccaag tgtcttccag    300

ctatgcaggg cagttcagag tgataggacc aagacaccct atccgggctc tggtcgggga    360

tgaagtggaa ttgccatgtc gcatatctcc tgggaagaac gctacaggca tggaggtggg    420

gtggtaccgc ccccccttct ctagggtggt tcatctctac agaaatggca aggaccaaga    480

tggagaccag gcacctgaat atcggggccg gacagagctg ctgaaagatg ctattggtga    540

gggaaaggtg actctcagga tccggaatgt aaggttctca gatgaaggag gtttcacctg    600

cttcttccga gatcattctt accaagagga ggcagcaatg gaattgaaag tagaagatcc    660

tttctactgg gtgagccctg gagtgctggt tctcctcgcg gtgctgcctg tgctcctcct    720

gcagatcact gttggcctca tcttcctctg cctgcagtac agactgagag gaaaacttcg    780

agcagagata gagaatctcc accggacttt tgggcaattc cttgaagagc tactcttcca    840

cctggaagcc ctctctggct aaggacaggc aggtgcccct ctctccatca gaggacacct    900

gtactggaga gcaacacagg atggtctctg ccatgaactg gaggccagga atctcctcac    960

tgaaaattac agtatggtaa ctttgcaaat ggtggttgtt tcttccaaga ctccagccct   1020

gattgcgcaa aactgaaagg catgtgaagg gaaggaagag gaagagtgca aaacattgaa   1080

gagagagctg agtgagctga agagtgagga tatgagtagc cccaacccaa acctggagat   1140

ggggagaaac ctacagaata ctagccagag ctcctccttg tcttggcagc ctactaggga   1200

cctggggaag caaaaacgaa agctgggcaa catgcctgct ttagaatgtt ttccttctac   1260

ttacacatct tccacaggtc tcagaatctt tccttcctct catccttttc tcctatcttc   1320

atatctatca gagtatccac tgtttattca acaactacta cttgatggtc agacacaaac   1380

aaacaagcta ggtgctaatt aataaagata cgagttttgg ccgggtgcgg tggctcacgc   1440

ctgtaatccc agcactttgg gaggccgagg cgggcgaatc acgaggtcag gagttcaaga   1500

ccagcctggc caacatggtg aaaccccatc tctactaaaa atacaaacaa ttaactgagc   1560

atagtggtgg gcacctataa taccagctac tccggaggct gaggcaggag aatcgcttga   1620

acccaggagg cagaggttgc agtgagctga gatcgtgcca ctgcactcta gccggagtga   1680

cagagtaaga ctctgtctca aaaataaata aataaataaa taaataaata aataaataaa   1740

taaataaaaa ataataatac aagttttcat aagcacactt ct                      1782


<210>  3205
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  3205

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190


Leu His Arg Thr Phe Gly Gln Phe Leu Glu Glu Leu Leu Phe His Leu 
        195                 200                 205


Glu Ala Leu Ser Gly 
    210


<210>  3206
<211>  1830
<212>  DNA
<213>  Homo sapiens

<400>  3206
tcagtctgta gcccttttgt gtgagtgcct ggcaagggtg acgtggggct gtttctgcgg     60

gcacagctgc agcaattacc ggagtggagg cagggcccag gcagcactgc cctccaagat    120

cttcccttgg gcttttcagc agtaagggga catgcacccc aagggcctcc acttggcctg    180

accttgctgc gggggctctc tgtccccagg aacagtagag atggcaagct tatcaagacc    240

ctctctgccc agctgcctct gctccttcct cctcctcctc ctcctccaag tgtcttccag    300

ctatgcaggg cagttcagag tgataggacc aagacaccct atccgggctc tggtcgggga    360

tgaagtggaa ttgccatgtc gcatatctcc tgggaagaac gctacaggca tggaggtggg    420

gtggtaccgc ccccccttct ctagggtggt tcatctctac agaaatggca aggaccaaga    480

tggagaccag gcacctgaat atcggggccg gacagagctg ctgaaagatg ctattggtga    540

gggaaaggtg actctcagga tccggaatgt aaggttctca gatgaaggag gtttcacctg    600

cttcttccga gatcattctt accaagagga ggcagcaatg gaattgaaag tagaagatcc    660

tttctactgg gtgagccctg gagtgctggt tctcctcgcg gtgctgcctg tgctcctcct    720

gcagatcact gttggcctca tcttcctctg cctgcagtac agactgagag gaaaacttcg    780

agcagagata gagaatctcc accggacttt tgagtccttt ggtgttctag gaccccaggt    840

taaggaacca aaaaagacag ggcaattcct tgaagagcta ctcttccacc tggaagccct    900

ctctggctaa ggacaggcag gtgcccctct ctccatcaga ggacacctgt actggagagc    960

aacacaggat ggtctctgcc atgaactgga ggccaggaat ctcctcactg aaaattacag   1020

tatggtaact ttgcaaatgg tggttgtttc ttccaagact ccagccctga ttgcgcaaaa   1080

ctgaaaggca tgtgaaggga aggaagagga agagtgcaaa acattgaaga gagagctgag   1140

tgagctgaag agtgaggata tgagtagccc caacccaaac ctggagatgg ggagaaacct   1200

acagaatact agccagagct cctccttgtc ttggcagcct actagggacc tggggaagca   1260

aaaacgaaag ctgggcaaca tgcctgcttt agaatgtttt ccttctactt acacatcttc   1320

cacaggtctc agaatctttc cttcctctca tccttttctc ctatcttcat atctatcaga   1380

gtatccactg tttattcaac aactactact tgatggtcag acacaaacaa acaagctagg   1440

tgctaattaa taaagatacg agttttggcc gggtgcggtg gctcacgcct gtaatcccag   1500

cactttggga ggccgaggcg ggcgaatcac gaggtcagga gttcaagacc agcctggcca   1560

acatggtgaa accccatctc tactaaaaat acaaacaatt aactgagcat agtggtgggc   1620

acctataata ccagctactc cggaggctga ggcaggagaa tcgcttgaac ccaggaggca   1680

gaggttgcag tgagctgaga tcgtgccact gcactctagc cggagtgaca gagtaagact   1740

ctgtctcaaa aataaataaa taaataaata aataaataaa taaataaata aataaaaaat   1800

aataatacaa gttttcataa gcacacttct                                    1830


<210>  3207
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  3207

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Ile Phe Leu 
                165                 170                 175


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190


Leu His Arg Thr Phe Glu Ser Phe Gly Val Leu Gly Pro Gln Val Lys 
        195                 200                 205


Glu Pro Lys Lys Thr Gly Gln Phe Leu Glu Glu Leu Leu Phe His Leu 
    210                 215                 220


Glu Ala Leu Ser Gly 
225


<210>  3208
<211>  1916
<212>  DNA
<213>  Homo sapiens

<400>  3208
taaggaggca gtacttttct catccaagtt catggacttt ctgaattttg tccccagagt     60

cctttggtgt tctaggaccc caggttaagg aaccaaaaaa gacaggtggg tggggcatga    120

gggggaacac atgttaaccc tgtttgttct ggtgaacaat tcagatcccc actttctgag    180

ggtgccctgc tggaagataa ccctgtttgt aattgtgccg gttcttggac ccttggttgc    240

cttgatcatc tgctacaact ggctacatcg aagactagca gggcaattcc ttgaagagct    300

acgtaagttc tcttctctct gttataagca gagaataaaa agccaggaaa gggagacaga    360

agcaacaaga ggaagaggcg ggctattgag ggatcacatt cccagaggaa aggaggagct    420

ggagagcctg ggtggaggga agactcctcc tgggaggtag agggcaaaga agccagctgt    480

tagagacaca tttacaggtg gcagagaagc tggaggcact cctatctgcc acctgatcca    540

ttcctccttc actgccccta agcaggaatc caaccctagc tggtctcatt gcccattcca    600

cagcaactgc ccagtgcctc acctctcaga tcaaccattg aggcaggaat ggagacaaga    660

tgaccccaag ggcttttctt ctccctagtt caatggtttt atgatacaaa ctactgacat    720

acgtttttca agttattttc tccttcttct aggaaatccc ttctgagtga tgtcacatct    780

tggcaggggt ggaggagagc ctggttgccc agggatttgt ccttggggac atctcatcca    840

tcaagttgca cactcactgg catctttgct atggggacat tccaatttgc actttcagga    900

acactctgaa ttccaagtag aattgatttc ccttcttctg tcatctacct tttctcttca    960

ttttcccatt tttattaccc ttctttccat ttctctctcc agtcttccac ctggaagccc   1020

tctctggcta aggacaggca ggtgcccctc tctccatcag aggacacctg tactggagag   1080

caacacagga tggtctctgc catgaactgg aggccaggaa tctcctcact gaaaattaca   1140

gtatggtaac tttgcaaatg gtggttgttt cttccaagac tccagccctg attgcgcaaa   1200

actgaaaggc atgtgaaggg aaggaagagg aagagtgcaa aacattgaag agagagctga   1260

gtgagctgaa gagtgaggat atgagtagcc ccaacccaaa cctggagatg gggagaaacc   1320

tacagaatac tagccagagc tcctccttgt cttggcagcc tactagggac ctggggaagc   1380

aaaaacgaaa gctgggcaac atgcctgctt tagaatgttt tccttctact tacacatctt   1440

ccacaggtct cagaatcttt ccttcctctc atccttttct cctatcttca tatctatcag   1500

agtatccact gtttattcaa caactactac ttgatggtca gacacaaaca aacaagctag   1560

gtgctaatta ataaagatac gagttttggc cgggtgcggt ggctcacgcc tgtaatccca   1620

gcactttggg aggccgaggc gggcgaatca cgaggtcagg agttcaagac cagcctggcc   1680

aacatggtga aaccccatct ctactaaaaa tacaaacaat taactgagca tagtggtggg   1740

cacctataat accagctact ccggaggctg aggcaggaga atcgcttgaa cccaggaggc   1800

agaggttgca gtgagctgag atcgtgccac tgcactctag ccggagtgac agagtaagac   1860

tctgtctcaa aaataaataa ataaataaat aaataaataa ataaataaat aaataa       1916


<210>  3209
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  3209

Met Leu Thr Leu Phe Val Leu Val Asn Asn Ser Asp Pro His Phe Leu 
1               5                   10                  15


Arg Val Pro Cys Trp Lys Ile Thr Leu Phe Val Ile Val Pro Val Leu 
            20                  25                  30


Gly Pro Leu Val Ala Leu Ile Ile Cys Tyr Asn Trp Leu His Arg Arg 
        35                  40                  45


Leu Ala Gly Gln Phe Leu Glu Glu Leu Arg Lys Phe Ser Ser Leu Cys 
    50                  55                  60


Tyr Lys Gln Arg Ile Lys Ser Gln Glu Arg Glu Thr Glu Ala Thr Arg 
65                  70                  75                  80


Gly Arg Gly Gly Leu Leu Arg Asp His Ile Pro Arg Gly Lys Glu Glu 
                85                  90                  95


Leu Glu Ser Leu Gly Gly Gly Lys Thr Pro Pro Gly Arg 
            100                 105


<210>  3210
<211>  1981
<212>  DNA
<213>  Homo sapiens

<400>  3210
tccccgggag accctgtgcc cctaaatcgc ggtccactgc gcgcgtcagg tttctagaag     60

cagggtagaa cagacggcag acacctagcc caggctggtg ttgttactaa acaatggcag    120

ctggtgagcc aagggtgacc agggccctga actcggtggc ccagctttga gggaagcaaa    180

attgttctca attgtggaag aggagaattt ggacagcaga acaaaaaagg aagacagcct    240

cttggagcag atacatttgt cacaggaagc cacatcaaac cctggggcct ttgctgggcc    300

tctccatctg cccagttact gggaggtaga tagccccagg aaggaatcca gtcaggcctg    360

ggcaccaggc caggagtgga taaagctaga aagagacacc acagaagaga agatgtttga    420

acagctgaag ccaatcgaac ctagagattg ctggagggag gcacgggtga agaagaagcc    480

agtcaccttt gaggatgtgg cagtgaattt cacccaggaa gagtgggact gtctagatgc    540

cagccagagg gtcctttacc aggatgttat gtcggaaacc tttaagaatc taacatctgt    600

ggccagaatc tttctgcata agccagagct aatcaccaag cttgagcaag aagaggaaca    660

gtggagagag tttgtccatc tcccaaacac agaaggcctt tcagaaggca agaagaaaga    720

gcttcgagaa caacatccca gtctgagaga tgaggggact agtgatgaca aggtcttcct    780

tgcatgcaga ggggccggcc agtgccccct atctgcccca gctgggacta tggacaggac    840

ccgggtgctt caagcatccc aggctgggcc accctttttt tgctacacct gtggcaaatg    900

tttcagcagg cgctcctacc tctatagcca ccagtttgtt cacaatccca agctgactaa    960

cagctgcagt cagtgtggga agttgtttcg gagccccaag tccctcagct atcacagacg   1020

catgcatctt ggggagaggc ccttctgttg cacgctctgt gacaagacct actgtgatgc   1080

ttctggacta agtcgtcacc gccgcgtcca tctgggttac cggccccatt catgctctgt   1140

gtgtgggaag agcttccggg accagtctga gctcaaacgc caccagaaga tacaccaaaa   1200

ccaggagcca gtggatggaa accaggagtg tactttgagg attccaggca cccaggctga   1260

attccagaca cccatcgcca gaagccagag gtccatccag gggcttttgg atgtgaacca   1320

tgcaccagtg gccaggtccc aggaacccat atttagaact gagggtccta tggcccagaa   1380

ccaggcatct gtacttaaga accaagcacc tgtgaccagg acccaggcac ccatcactgg   1440

aaccctctgt caggatgcca gatccaactc tcatccagtg aagccctcaa gactcaatgt   1500

cttctgttgc ccccattgtt ctttgacttt tagcaagaaa tcctatctct ccagacacca   1560

gaaggcccac ctcacagagc cgcccaacta ctgcttccat tgcagcaagt ctttcagctc   1620

attttccagg ctggtcagac accagcagac ccactggaag cagaagagct acctttgccc   1680

tatctgtgac ctctcctttg gggagaaaga gggccttatg gatcactgga ggggctataa   1740

aggcaaggac ctgtgccaga gcagccacca taaatgccgg gtgatcctgg gccagtggct   1800

tggcttctct catgatgtcc ccactatggc tggggaggaa tggaagcatg gaggtgatca   1860

atctcccccc aggatccata cccccaggag aagaggccta agagagaagg cctgcaaagg   1920

agacaaaaca aaggaggcag tgagcatctt gaaacataaa taaatggcct ttctgactga   1980

g                                                                   1981


<210>  3211
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  3211

Met Phe Glu Gln Leu Lys Pro Ile Glu Pro Arg Asp Cys Trp Arg Glu 
1               5                   10                  15


Ala Arg Val Lys Lys Lys Pro Val Thr Phe Glu Asp Val Ala Val Asn 
            20                  25                  30


Phe Thr Gln Glu Glu Trp Asp Cys Leu Asp Ala Ser Gln Arg Val Leu 
        35                  40                  45


Tyr Gln Asp Val Met Ser Glu Thr Phe Lys Asn Leu Thr Ser Val Ala 
    50                  55                  60


Arg Ile Phe Leu His Lys Pro Glu Leu Ile Thr Lys Leu Glu Gln Glu 
65                  70                  75                  80


Glu Glu Gln Trp Arg Glu Phe Val His Leu Pro Asn Thr Glu Gly Leu 
                85                  90                  95


Ser Glu Gly Lys Lys Lys Glu Leu Arg Glu Gln His Pro Ser Leu Arg 
            100                 105                 110


Asp Glu Gly Thr Ser Asp Asp Lys Val Phe Leu Ala Cys Arg Gly Ala 
        115                 120                 125


Gly Gln Cys Pro Leu Ser Ala Pro Ala Gly Thr Met Asp Arg Thr Arg 
    130                 135                 140


Val Leu Gln Ala Ser Gln Ala Gly Pro Pro Phe Phe Cys Tyr Thr Cys 
145                 150                 155                 160


Gly Lys Cys Phe Ser Arg Arg Ser Tyr Leu Tyr Ser His Gln Phe Val 
                165                 170                 175


His Asn Pro Lys Leu Thr Asn Ser Cys Ser Gln Cys Gly Lys Leu Phe 
            180                 185                 190


Arg Ser Pro Lys Ser Leu Ser Tyr His Arg Arg Met His Leu Gly Glu 
        195                 200                 205


Arg Pro Phe Cys Cys Thr Leu Cys Asp Lys Thr Tyr Cys Asp Ala Ser 
    210                 215                 220


Gly Leu Ser Arg His Arg Arg Val His Leu Gly Tyr Arg Pro His Ser 
225                 230                 235                 240


Cys Ser Val Cys Gly Lys Ser Phe Arg Asp Gln Ser Glu Leu Lys Arg 
                245                 250                 255


His Gln Lys Ile His Gln Asn Gln Glu Pro Val Asp Gly Asn Gln Glu 
            260                 265                 270


Cys Thr Leu Arg Ile Pro Gly Thr Gln Ala Glu Phe Gln Thr Pro Ile 
        275                 280                 285


Ala Arg Ser Gln Arg Ser Ile Gln Gly Leu Leu Asp Val Asn His Ala 
    290                 295                 300


Pro Val Ala Arg Ser Gln Glu Pro Ile Phe Arg Thr Glu Gly Pro Met 
305                 310                 315                 320


Ala Gln Asn Gln Ala Ser Val Leu Lys Asn Gln Ala Pro Val Thr Arg 
                325                 330                 335


Thr Gln Ala Pro Ile Thr Gly Thr Leu Cys Gln Asp Ala Arg Ser Asn 
            340                 345                 350


Ser His Pro Val Lys Pro Ser Arg Leu Asn Val Phe Cys Cys Pro His 
        355                 360                 365


Cys Ser Leu Thr Phe Ser Lys Lys Ser Tyr Leu Ser Arg His Gln Lys 
    370                 375                 380


Ala His Leu Thr Glu Pro Pro Asn Tyr Cys Phe His Cys Ser Lys Ser 
385                 390                 395                 400


Phe Ser Ser Phe Ser Arg Leu Val Arg His Gln Gln Thr His Trp Lys 
                405                 410                 415


Gln Lys Ser Tyr Leu Cys Pro Ile Cys Asp Leu Ser Phe Gly Glu Lys 
            420                 425                 430


Glu Gly Leu Met Asp His Trp Arg Gly Tyr Lys Gly Lys Asp Leu Cys 
        435                 440                 445


Gln Ser Ser His His Lys Cys Arg Val Ile Leu Gly Gln Trp Leu Gly 
    450                 455                 460


Phe Ser His Asp Val Pro Thr Met Ala Gly Glu Glu Trp Lys His Gly 
465                 470                 475                 480


Gly Asp Gln Ser Pro Pro Arg Ile His Thr Pro Arg Arg Arg Gly Leu 
                485                 490                 495


Arg Glu Lys Ala Cys Lys Gly Asp Lys Thr Lys Glu Ala Val Ser Ile 
            500                 505                 510


Leu Lys His Lys 
        515


<210>  3212
<211>  808
<212>  DNA
<213>  Homo sapiens

<400>  3212
ccgccgcgtc catctgggtt accggcccca ttcatgctct gtgtgtggga agagcttccg     60

ggaccagtct gagctcaaac gccaccagaa gatacaccaa aaccaggagc cagtggatgg    120

aaaccaggag tgtactttga ggattccagg cacccaggct gaattccaga cacccatcgc    180

cagaagccag aggtccatcc aggggctttt ggatgtgaac catgcaccag tggccaggtc    240

ccaggaaccc atatttagaa ctgagggtcc tatggcccag aaccaggcat ctgtacttaa    300

gaaccaagca cctgtgacca ggacccaggc acccatcact ggaaccctct gtcaggatgc    360

cagatccaac tctcatccag tgaagccctc aagactcaat gtcttctgtt gcccccattg    420

ttctttgact tttacaagtc tttcagctca ttttccaggc tggtcagaca ccagcagacc    480

cactggaagc agaagagcta cctttgccct atctgtgacc tctcctttgg ggagaaagag    540

ggccttatgg atcactggag gggctataaa ggcaaggacc tgtgccagag cagccaccat    600

aaatgccggg tgatcctggg ccagtggctt ggcttctctc atgatgtccc cactatggct    660

ggggaggaat ggaagcatgg aggtgatcaa tctcccccca ggatccatac ccccaggaga    720

agaggcctaa gagagaaggc ctgcaaagga gacaaaacaa aggaggcagt gagcatcttg    780

aaacataaat aaatggcctt tctgactg                                       808


<210>  3213
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  3213

Met Ala Gln Asn Gln Ala Ser Val Leu Lys Asn Gln Ala Pro Val Thr 
1               5                   10                  15


Arg Thr Gln Ala Pro Ile Thr Gly Thr Leu Cys Gln Asp Ala Arg Ser 
            20                  25                  30


Asn Ser His Pro Val Lys Pro Ser Arg Leu Asn Val Phe Cys Cys Pro 
        35                  40                  45


His Cys Ser Leu Thr Phe Thr Ser Leu Ser Ala His Phe Pro Gly Trp 
    50                  55                  60


Ser Asp Thr Ser Arg Pro Thr Gly Ser Arg Arg Ala Thr Phe Ala Leu 
65                  70                  75                  80


Ser Val Thr Ser Pro Leu Gly Arg Lys Arg Ala Leu Trp Ile Thr Gly 
                85                  90                  95


Gly Ala Ile Lys Ala Arg Thr Cys Ala Arg Ala Ala Thr Ile Asn Ala 
            100                 105                 110


Gly 



<210>  3214
<211>  1783
<212>  DNA
<213>  Homo sapiens

<400>  3214
gactacattg cccagtaacc tcctgggctc cgctgtgttt ttctattctg gggtgtaagg     60

ggcagctgga ccactccagc tgggactgct aggaaggttg cgggtccacc cggccgagcc    120

gaacgaggga aatggtcctc acccggccac tcgccggttg aaaaggggcc gccctggcag    180

ggaagcggcc gccgcggcgc ggtgcagcgc agcggcgaga aggagtgcgt tatcgtcttg    240

cgctactgct gaatgtccgt cccggaggag gaggagaggc ttttgccgct gacccagaga    300

tggccccgag cgagcaaatt cctactgtcc ggctgcgcgg ctaccgtggc cgagctagca    360

acctttcccc tggatctcac aaaaactcga ctccaaatgc aaggagaagc agctcttgct    420

cggttgggag acggtgcaag agaatctgcc ccctataggg gaatggtgcg cacagctcta    480

gggatcattg aagaggaagg ctttctaaag ctttggcaag gagtgacacc cgccatttac    540

agacacgtag tgtattctgg aggtcgaatg gtcacatatg aacatctccg agaggttgtg    600

tttggcaaaa gtgaagatga gcattatccc ctttggaaat cagtcattgg agggatgatg    660

gctggtgtta ttggccagtt tttagccaat ccaactgacc tagtgaaggt tcagatgcaa    720

atggaaggaa aaaggaaact ggaaggaaaa ccattgcgat ttcgtggtgt acatcatgca    780

tttgcaaaaa tcttagctga aggaggaata cgagggcttt gggcaggctg ggtacccaat    840

atacaaagag cagcactggt gaatatggga gatttaacca cttatgatac agtgaaacac    900

tacttggtat tgaatacacc acttgaggac aatatcatga ctcacggttt atcaagttta    960

tgttctggac tggtagcttc tattctggga acaccagccg atgtcatcaa aagcagaata   1020

atgaatcaac cacgagataa acaaggaagg ggacttttgt ataaatcatc gactgactgc   1080

ttgattcagg ctgttcaagg tgaaggattc atgagtctat ataaaggctt tttaccatct   1140

tggctgagaa tgaccccttg gtcaatggtg ttctggctta cttatgaaaa aatcagagag   1200

atgagtggag tcagtccatt ttaaacccct aaagatgcaa cccttaaaga tacagtgttc   1260

agtattattg aaatatgggc atctgcaaca cataccccct attatttcta cctctttagg   1320

aagacaccta ttccacagag actgatttat agggggcagc actttatttt tttctggaaa   1380

cccaagttct ctttgactcc tctttttgtc caaaagtgat ctggtcggat ctcacaaggc   1440

catccaatga gaccccgcac agcattttct aaagaagaat cgaagcctga ccactttcac   1500

cttgggcaag aaggtttggc ctttgagttg ctattctatg ctgaagagcc tgcttagagg   1560

aggagtacca ggagggagcc agcatttcag atctgaagta gacgatagga atgtggaaga   1620

acacatacat agtgcttaag aaatacattt aacctgttat gtcagtattt atcaatgaag   1680

tttgataatt cacttttctg tcattgttaa agcgtacata ctgtaaatta aagggaggtg   1740

aatggaaatt aatgaataaa cattttgagt ttccctagtg ttg                     1783


<210>  3215
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  3215

Met Ser Val Pro Glu Glu Glu Glu Arg Leu Leu Pro Leu Thr Gln Arg 
1               5                   10                  15


Trp Pro Arg Ala Ser Lys Phe Leu Leu Ser Gly Cys Ala Ala Thr Val 
            20                  25                  30


Ala Glu Leu Ala Thr Phe Pro Leu Asp Leu Thr Lys Thr Arg Leu Gln 
        35                  40                  45


Met Gln Gly Glu Ala Ala Leu Ala Arg Leu Gly Asp Gly Ala Arg Glu 
    50                  55                  60


Ser Ala Pro Tyr Arg Gly Met Val Arg Thr Ala Leu Gly Ile Ile Glu 
65                  70                  75                  80


Glu Glu Gly Phe Leu Lys Leu Trp Gln Gly Val Thr Pro Ala Ile Tyr 
                85                  90                  95


Arg His Val Val Tyr Ser Gly Gly Arg Met Val Thr Tyr Glu His Leu 
            100                 105                 110


Arg Glu Val Val Phe Gly Lys Ser Glu Asp Glu His Tyr Pro Leu Trp 
        115                 120                 125


Lys Ser Val Ile Gly Gly Met Met Ala Gly Val Ile Gly Gln Phe Leu 
    130                 135                 140


Ala Asn Pro Thr Asp Leu Val Lys Val Gln Met Gln Met Glu Gly Lys 
145                 150                 155                 160


Arg Lys Leu Glu Gly Lys Pro Leu Arg Phe Arg Gly Val His His Ala 
                165                 170                 175


Phe Ala Lys Ile Leu Ala Glu Gly Gly Ile Arg Gly Leu Trp Ala Gly 
            180                 185                 190


Trp Val Pro Asn Ile Gln Arg Ala Ala Leu Val Asn Met Gly Asp Leu 
        195                 200                 205


Thr Thr Tyr Asp Thr Val Lys His Tyr Leu Val Leu Asn Thr Pro Leu 
    210                 215                 220


Glu Asp Asn Ile Met Thr His Gly Leu Ser Ser Leu Cys Ser Gly Leu 
225                 230                 235                 240


Val Ala Ser Ile Leu Gly Thr Pro Ala Asp Val Ile Lys Ser Arg Ile 
                245                 250                 255


Met Asn Gln Pro Arg Asp Lys Gln Gly Arg Gly Leu Leu Tyr Lys Ser 
            260                 265                 270


Ser Thr Asp Cys Leu Ile Gln Ala Val Gln Gly Glu Gly Phe Met Ser 
        275                 280                 285


Leu Tyr Lys Gly Phe Leu Pro Ser Trp Leu Arg Met Thr Pro Trp Ser 
    290                 295                 300


Met Val Phe Trp Leu Thr Tyr Glu Lys Ile Arg Glu Met Ser Gly Val 
305                 310                 315                 320


Ser Pro Phe 



<210>  3216
<211>  1323
<212>  DNA
<213>  Homo sapiens

<400>  3216
gactacattg cccagtaacc tcctgggctc cgctgtgttt ttctattctg gggtgtaagg     60

ggcagctgga ccactccagc tgggactgct aggaaggttg cgggtccacc cggccgagcc    120

gaacgaggga aatggtcctc acccggccac tcgccggttg aaaaggggcc gccctggcag    180

ggaagcggcc gccgcggcgc ggtgcagcgc agcggcgaga aggagtgcgt tatcgtcttg    240

cgctactgct gaatgtccgt cccggaggag gaggagaggc ttttgccgct gacccagaga    300

tggccccgag cgagcaaatt cctactgtcc ggctgcgcgg ctaccgtggc cgagctagca    360

acctttcccc tggatctcac aaaaactcga ctccaaatgc aaggagaagc agctcttgct    420

cggttgggag acggtgcaag agaatctgcc ccctataggg gaatggtgcg cacagctcta    480

gggatcattg aagaggaagg ctttctaaag ctttggcaag gagtgacacc cgccatttac    540

agacacgtag tgtattctgg aggtcgaatg gtcacatatg aacatctccg agaggttgtg    600

tttggcaaaa gtgaagatga gcattatccc ctttggaaat cagtcattgg agggatgatg    660

gctggtgtta ttggccagtt tttagccaat ccaactgacc tagtgaaggt tcagatgcaa    720

atggaaggaa aaaggaaact ggaaggaaaa ccattgcgat ttcgtggtgt acatcatgca    780

tttgcaaaaa tcttagctga aggaggaata cgagggcttt gggcaggctg ggtacccaat    840

atacaaagag cagcactggt gaatatggga gatttaacca cttatgatac agtgaaacac    900

tacttggtat tgaatacacc acttgaggac aatatcatga ctcacggttt atcaagtgat    960

ctggtcggat ctcacaaggc catccaatga gaccccgcac agcattttct aaagaagaat   1020

cgaagcctga ccactttcac cttgggcaag aaggtttggc ctttgagttg ctattctatg   1080

ctgaagagcc tgcttagagg aggagtacca ggagggagcc agcatttcag atctgaagta   1140

gacgatagga atgtggaaga acacatacat agtgcttaag aaatacattt aacctgttat   1200

gtcagtattt atcaatgaag tttgataatt cacttttctg tcattgttaa agcgtacata   1260

ctgtaaatta aagggaggtg aatggaaatt aatgaataaa cattttgagt ttccctagtg   1320

ttg                                                                 1323


<210>  3217
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  3217

Met Ser Val Pro Glu Glu Glu Glu Arg Leu Leu Pro Leu Thr Gln Arg 
1               5                   10                  15


Trp Pro Arg Ala Ser Lys Phe Leu Leu Ser Gly Cys Ala Ala Thr Val 
            20                  25                  30


Ala Glu Leu Ala Thr Phe Pro Leu Asp Leu Thr Lys Thr Arg Leu Gln 
        35                  40                  45


Met Gln Gly Glu Ala Ala Leu Ala Arg Leu Gly Asp Gly Ala Arg Glu 
    50                  55                  60


Ser Ala Pro Tyr Arg Gly Met Val Arg Thr Ala Leu Gly Ile Ile Glu 
65                  70                  75                  80


Glu Glu Gly Phe Leu Lys Leu Trp Gln Gly Val Thr Pro Ala Ile Tyr 
                85                  90                  95


Arg His Val Val Tyr Ser Gly Gly Arg Met Val Thr Tyr Glu His Leu 
            100                 105                 110


Arg Glu Val Val Phe Gly Lys Ser Glu Asp Glu His Tyr Pro Leu Trp 
        115                 120                 125


Lys Ser Val Ile Gly Gly Met Met Ala Gly Val Ile Gly Gln Phe Leu 
    130                 135                 140


Ala Asn Pro Thr Asp Leu Val Lys Val Gln Met Gln Met Glu Gly Lys 
145                 150                 155                 160


Arg Lys Leu Glu Gly Lys Pro Leu Arg Phe Arg Gly Val His His Ala 
                165                 170                 175


Phe Ala Lys Ile Leu Ala Glu Gly Gly Ile Arg Gly Leu Trp Ala Gly 
            180                 185                 190


Trp Val Pro Asn Ile Gln Arg Ala Ala Leu Val Asn Met Gly Asp Leu 
        195                 200                 205


Thr Thr Tyr Asp Thr Val Lys His Tyr Leu Val Leu Asn Thr Pro Leu 
    210                 215                 220


Glu Asp Asn Ile Met Thr His Gly Leu Ser Ser Asp Leu Val Gly Ser 
225                 230                 235                 240


His Lys Ala Ile Gln 
                245


<210>  3218
<211>  2961
<212>  DNA
<213>  Homo sapiens

<400>  3218
gactacattg cccagtaacc tcctgggctc cgctgtgttt ttctattctg gggtgtaagg     60

ggcagctgga ccactccagc tgggactgct aggaaggttg cgggtccacc cggccgagcc    120

gaacgaggga aatggtcctc acccggccac tcgccggttg aaaaggggcc gccctggcag    180

ggaagcggcc gccgcggcgc ggtgcagcgc agcggcgaga aggagtgcgt tatcgtcttg    240

cgctactgct gaatgtccgt cccggaggag gaggagaggc ttttgccgct gacccagaga    300

tggccccgag cgagcaaatt cctactgtcc ggctgcgcgg ctaccgtggc cgagctagca    360

acctttcccc tggatctcac aaaaactcga ctccaaatgc aaggagaagc agctcttgct    420

cggttgggag acggtgcaag agaatctgcc ccctataggg gaatggtgcg cacagctcta    480

gggatcattg aagaggaagg ctttctaaag ctttggcaag gagtgacacc cgccatttac    540

agacacgtag tgtattctgg aggtcgaatg gtcacatatg aacatctccg agaggttgtg    600

tttggcaaaa gtgaagatga gcattatccc ctttggaaat cagtcattgg agggatgatg    660

gctggtgtta ttggccagtt tttagccaat ccaactgacc tagtgaaggt tcagatgcaa    720

atggaaggaa aaaggaaact ggaaggaaaa ccattgcgat ttcgtggtgt acatcatgca    780

tttgcaaaaa tcttagctga aggaggaata cgagggcttt gggcaggctg ggtacccaat    840

atacaaagag cagcactggt gaatatggga gatttaacca cttatgatac agtgaaacac    900

tacttggtat tgaatacacc acttgaggac aatatcatga ctcacggttt atcaagttta    960

tgttctggac tggtagcttc tattctggga acaccagccg atgtcatcaa aagcagaata   1020

atgaatcaac cacgagataa acaaggaagg ggacttttgt ataaatcatc gactgactgc   1080

ttgattcagg ctgttcaagg tgaaggattc atgagtctat ataaaggctt tttaccatct   1140

tggctgagaa tgaccccttg gtcaatggtg ttctggctta cttatgaaaa aatcagagag   1200

atgagtggag tcagtccatt ttaaacccct aaagatgcaa cccttaaaga tacagtgttc   1260

agtattattg aaatatgggc atctgcaaca cataccccct attatttcta cctctttagg   1320

aagacaccta ttccacagag actgatttat agggggcagc actttatttt tttctggaaa   1380

cccaagttct ctttgactcc tctttttgtc caaaagtgat ctggtcggat ctcacaaggc   1440

catccaatga gaccccgcac agcattttct aaagaagaat cgaagcctga ccactttcac   1500

cttgggcaag aaggtttggc ctttgagttg ctattctatg ctgaagagcc tgcttagagg   1560

aggagtacca ggagggagcc agcatttcag atctgaagta gacgatagga atgtggaaga   1620

acacatacat agtgcttaag aaatacattt aacctgttat gtcagtattt atcaatgaag   1680

tttgataatt cacttttctg tcattgttaa agcgtacata ctgtaaatta aagggaggtg   1740

aatggaaatt aatgaataaa cattttgagt ttccctagtg ttgaaggaag gtgtactttt   1800

tcttgtcaga aagataaaaa aaatcaagtt gagatgatgt ttgaatttca agaaaagagg   1860

ctgctttctg tcagtgccct ctcattagat ctgtgttaat tagttagcac tccactgcac   1920

atgctaatga cttcctctga cagccacaca ccgaatcttg atgaaaaaag agaagagcat   1980

ttgccttgtt acatagtctg ttacaagcca gatatgttgc tagctctcaa gagttgtaat   2040

atattaagaa ctacaactta tttgattaaa actcagctgt atagatcctt ttataaagca   2100

ccttttgtta aacatcagcc tttcattggt attttaaaag caaggcagat agatatgaag   2160

tcagccaact ctgacatgcg tcctttctta tctcccttac ctgacactag gggctctaga   2220

gaggcagaga gagcactcac aaatcacact aaaactgcca gcggcctgac tcttactcag   2280

tttagcaaaa attcttgcct aaaaagtgat aagtaaaaat ctgtttatgg tatacagtta   2340

tgtctcgaat ctttgaatca aatccatgtt cttattttag aaaggtaaga gttcttcaaa   2400

ttcagctaca taccaccggc tctcccaacc tcagacggtg ggcatttctg gatggatggc   2460

tgcggttatg gataaaggct gtaactgtta acacagaaaa acatgaaaag ctcaggccca   2520

agaaaggcct tggagccagc caaacagaat ttgttctaat ggacatggat gatgttgaac   2580

agaaaaaagt ttacaagtgc tttgtggttg cactaatgta tactcactgc cattttaaga   2640

gggggaagta cattttaaaa tatatttgaa tgtcatgtac tgatatgcag tagcttattg   2700

tttttctagt tgcagagaat gtgaagttta atctcttaaa atatttagat ggtctacttt   2760

ttcattgaat ttgtcaatat gtaattgcgt tgtaaaatat tatatatata tatatatata   2820

tatatatata tatatgctta acttcccaag tgttctgcat tgaaccactt agggaaaatt   2880

ttgtttgttt ttatgttttg taatttttaa aattaagtaa agactggatc aaaataattg   2940

catccaacct ggaccgtgaa c                                             2961


<210>  3219
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  3219

Met Ser Val Pro Glu Glu Glu Glu Arg Leu Leu Pro Leu Thr Gln Arg 
1               5                   10                  15


Trp Pro Arg Ala Ser Lys Phe Leu Leu Ser Gly Cys Ala Ala Thr Val 
            20                  25                  30


Ala Glu Leu Ala Thr Phe Pro Leu Asp Leu Thr Lys Thr Arg Leu Gln 
        35                  40                  45


Met Gln Gly Glu Ala Ala Leu Ala Arg Leu Gly Asp Gly Ala Arg Glu 
    50                  55                  60


Ser Ala Pro Tyr Arg Gly Met Val Arg Thr Ala Leu Gly Ile Ile Glu 
65                  70                  75                  80


Glu Glu Gly Phe Leu Lys Leu Trp Gln Gly Val Thr Pro Ala Ile Tyr 
                85                  90                  95


Arg His Val Val Tyr Ser Gly Gly Arg Met Val Thr Tyr Glu His Leu 
            100                 105                 110


Arg Glu Val Val Phe Gly Lys Ser Glu Asp Glu His Tyr Pro Leu Trp 
        115                 120                 125


Lys Ser Val Ile Gly Gly Met Met Ala Gly Val Ile Gly Gln Phe Leu 
    130                 135                 140


Ala Asn Pro Thr Asp Leu Val Lys Val Gln Met Gln Met Glu Gly Lys 
145                 150                 155                 160


Arg Lys Leu Glu Gly Lys Pro Leu Arg Phe Arg Gly Val His His Ala 
                165                 170                 175


Phe Ala Lys Ile Leu Ala Glu Gly Gly Ile Arg Gly Leu Trp Ala Gly 
            180                 185                 190


Trp Val Pro Asn Ile Gln Arg Ala Ala Leu Val Asn Met Gly Asp Leu 
        195                 200                 205


Thr Thr Tyr Asp Thr Val Lys His Tyr Leu Val Leu Asn Thr Pro Leu 
    210                 215                 220


Glu Asp Asn Ile Met Thr His Gly Leu Ser Ser Leu Cys Ser Gly Leu 
225                 230                 235                 240


Val Ala Ser Ile Leu Gly Thr Pro Ala Asp Val Ile Lys Ser Arg Ile 
                245                 250                 255


Met Asn Gln Pro Arg Asp Lys Gln Gly Arg Gly Leu Leu Tyr Lys Ser 
            260                 265                 270


Ser Thr Asp Cys Leu Ile Gln Ala Val Gln Gly Glu Gly Phe Met Ser 
        275                 280                 285


Leu Tyr Lys Gly Phe Leu Pro Ser Trp Leu Arg Met Thr Pro Trp Ser 
    290                 295                 300


Met Val Phe Trp Leu Thr Tyr Glu Lys Ile Arg Glu Met Ser Gly Val 
305                 310                 315                 320


Ser Pro Phe 



<210>  3220
<211>  3759
<212>  DNA
<213>  Homo sapiens

<400>  3220
tttgtatagg tttaagaaag aaaaagtgaa tagctgatta tcatttttct tcacttaaga     60

actttaaaca cagaatttaa atttttcata ttttttgaaa attaacatat atttattaca    120

gtgccaaatc tcatgagtcc ctgtctcata atctaagacc aggctactct gaaagaggac    180

agagttcact gcctaatcca acactggctg tagtgtaaat gcaacacagg tgatttttgc    240

cccagttcca aggctaccta actagctatg tgggccttag tcacccttaa aggaagatgg    300

ttgcaactat gccagttaga acatttttct gctctgcttc cacagtggca ctcacaagag    360

gaggacttga ttttatagct tgtgtacagg agaatataaa gttggcttca aaggaggtag    420

gataggtttg gcatttttct cctcataatg tttcctgaag catgaaagga tccttgatca    480

gaagagtgct cagttctaat ttctaaaatt tgctggctta atatttttaa agattcaatt    540

ctccatatga gtaagttagc gtgtatcatc aaaaactatc tagaactgtg tgcagagact    600

gttactggtt ttccaagttg tatatttttg agtatcttaa aatatttcat caactttcta    660

aaacatcaag aaaagctctc tatacaaata ccatggttga ttttaattat tttgttttcc    720

atccttttaa aaatattttc tgctttgcat cccattatta ttttgagttt cttttcattt    780

gtagtttgtt gttcattgtg ttgttttaca gctaagattc atttcatacg tttgatgctt    840

agctgaaaaa ttacaataaa ttctccaatg aaattatgta tctttattta atgaaaatgc    900

ctgctgcgta ccaaggtatg tactagggca tctggggtaa gtaaaaacaa acacatagag    960

cctgcctgga gaagctcatg gtctgatgga aagataagca agaagagtta atttctaatc   1020

aatatgataa aaaggtcaga gagcagtttc tgaaaaacat gtttttgagt tgagtcctga   1080

aagacaagga gatgttagta aagcagagaa gggagaattc attctagaaa gatcagacag   1140

tgtgtgggaa gggcagagtc tgaaaagagc atgccccatt tggagaagca tcaagaagcc   1200

cacgtgttag aagcaccggc cccatgagac aaagacacag ctagagagat tgactaggcc   1260

atgtcggaat gtcctcttat tttatacata cataagcata tagatacata tagccaaagt   1320

taccttttta atgatctttt ttacccagtg tattctggag gtcgaatggt cacatatgaa   1380

catctccgag aggttgtgtt tggcaaaagt gaagatgagc attatcccct ttggaaatca   1440

gtcattggag ggatgatggc tggtgttatt ggccagtttt tagccaatcc aactgaccta   1500

gtgaaggttc agatgcaaat ggaaggaaaa aggaaactgg aaggaaaacc attgcgattt   1560

cgtggtgtac atcatgcatt tgcaaaaatc ttagctgaag gaggaatacg agggctttgg   1620

gcaggctggg tacccaatat acaaagagca gcactggtga atatgggaga tttaaccact   1680

tatgatacag tgaaacacta cttggtattg aatacaccac ttgaggacaa tatcatgact   1740

cacggtttat caagtttatg ttctggactg gtagcttcta ttctgggaac accagccgat   1800

gtcatcaaaa gcagaataat gaatcaacca cgagataaac aaggaagggg acttttgtat   1860

aaatcatcga ctgactgctt gattcaggct gttcaaggtg aaggattcat gagtctatat   1920

aaaggctttt taccatcttg gctgagaatg accccttggt caatggtgtt ctggcttact   1980

tatgaaaaaa tcagagagat gagtggagtc agtccatttt aaacccctaa agatgcaacc   2040

cttaaagata cagtgttcag tattattgaa atatgggcat ctgcaacaca taccccctat   2100

tatttctacc tctttaggaa gacacctatt ccacagagac tgatttatag ggggcagcac   2160

tttatttttt tctggaaacc caagttctct ttgactcctc tttttgtcca aaagtgatct   2220

ggtcggatct cacaaggcca tccaatgaga ccccgcacag cattttctaa agaagaatcg   2280

aagcctgacc actttcacct tgggcaagaa ggtttggcct ttgagttgct attctatgct   2340

gaagagcctg cttagaggag gagtaccagg agggagccag catttcagat ctgaagtaga   2400

cgataggaat gtggaagaac acatacatag tgcttaagaa atacatttaa cctgttatgt   2460

cagtatttat caatgaagtt tgataattca cttttctgtc attgttaaag cgtacatact   2520

gtaaattaaa gggaggtgaa tggaaattaa tgaataaaca ttttgagttt ccctagtgtt   2580

gaaggaaggt gtactttttc ttgtcagaaa gataaaaaaa atcaagttga gatgatgttt   2640

gaatttcaag aaaagaggct gctttctgtc agtgccctct cattagatct gtgttaatta   2700

gttagcactc cactgcacat gctaatgact tcctctgaca gccacacacc gaatcttgat   2760

gaaaaaagag aagagcattt gccttgttac atagtctgtt acaagccaga tatgttgcta   2820

gctctcaaga gttgtaatat attaagaact acaacttatt tgattaaaac tcagctgtat   2880

agatcctttt ataaagcacc ttttgttaaa catcagcctt tcattggtat tttaaaagca   2940

aggcagatag atatgaagtc agccaactct gacatgcgtc ctttcttatc tcccttacct   3000

gacactaggg gctctagaga ggcagagaga gcactcacaa atcacactaa aactgccagc   3060

ggcctgactc ttactcagtt tagcaaaaat tcttgcctaa aaagtgataa gtaaaaatct   3120

gtttatggta tacagttatg tctcgaatct ttgaatcaaa tccatgttct tattttagaa   3180

aggtaagagt tcttcaaatt cagctacata ccaccggctc tcccaacctc agacggtggg   3240

catttctgga tggatggctg cggttatgga taaaggctgt aactgttaac acagaaaaac   3300

atgaaaagct caggcccaag aaaggccttg gagccagcca aacagaattt gttctaatgg   3360

acatggatga tgttgaacag aaaaaagttt acaagtgctt tgtggttgca ctaatgtata   3420

ctcactgcca ttttaagagg gggaagtaca ttttaaaata tatttgaatg tcatgtactg   3480

atatgcagta gcttattgtt tttctagttg cagagaatgt gaagtttaat ctcttaaaat   3540

atttagatgg tctacttttt cattgaattt gtcaatatgt aattgcgttg taaaatatta   3600

tatatatata tatatatata tatatatata tatgcttaac ttcccaagtg ttctgcattg   3660

aaccacttag ggaaaatttt gtttgttttt atgttttgta atttttaaaa ttaagtaaag   3720

actggatcaa aataattgca tccaacctgg accgtgaac                          3759


<210>  3221
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  3221

Met Ser Glu Cys Pro Leu Ile Leu Tyr Ile His Lys His Ile Asp Thr 
1               5                   10                  15


Tyr Ser Gln Ser Tyr Leu Phe Asn Asp Leu Phe Tyr Pro Val Tyr Ser 
            20                  25                  30


Gly Gly Arg Met Val Thr Tyr Glu His Leu Arg Glu Val Val Phe Gly 
        35                  40                  45


Lys Ser Glu Asp Glu His Tyr Pro Leu Trp Lys Ser Val Ile Gly Gly 
    50                  55                  60


Met Met Ala Gly Val Ile Gly Gln Phe Leu Ala Asn Pro Thr Asp Leu 
65                  70                  75                  80


Val Lys Val Gln Met Gln Met Glu Gly Lys Arg Lys Leu Glu Gly Lys 
                85                  90                  95


Pro Leu Arg Phe Arg Gly Val His His Ala Phe Ala Lys Ile Leu Ala 
            100                 105                 110


Glu Gly Gly Ile Arg Gly Leu Trp Ala Gly Trp Val Pro Asn Ile Gln 
        115                 120                 125


Arg Ala Ala Leu Val Asn Met Gly Asp Leu Thr Thr Tyr Asp Thr Val 
    130                 135                 140


Lys His Tyr Leu Val Leu Asn Thr Pro Leu Glu Asp Asn Ile Met Thr 
145                 150                 155                 160


His Gly Leu Ser Ser Leu Cys Ser Gly Leu Val Ala Ser Ile Leu Gly 
                165                 170                 175


Thr Pro Ala Asp Val Ile Lys Ser Arg Ile Met Asn Gln Pro Arg Asp 
            180                 185                 190


Lys Gln Gly Arg Gly Leu Leu Tyr Lys Ser Ser Thr Asp Cys Leu Ile 
        195                 200                 205


Gln Ala Val Gln Gly Glu Gly Phe Met Ser Leu Tyr Lys Gly Phe Leu 
    210                 215                 220


Pro Ser Trp Leu Arg Met Thr Pro Trp Ser Met Val Phe Trp Leu Thr 
225                 230                 235                 240


Tyr Glu Lys Ile Arg Glu Met Ser Gly Val Ser Pro Phe 
                245                 250


<210>  3222
<211>  1910
<212>  DNA
<213>  Homo sapiens

<400>  3222
tgaaattaat ggcaacttta aaaagaattt ccttctgcaa ttaggaaatc agtcattgga     60

gggatgatgg ctggtgttat tggccagttt ttagccaatc caactgacct agtgaaggtt    120

cagatgcaaa tggaaggaaa aaggaaactg gaaggaaaac cattgcgatt tcgtggtgta    180

catcatgcat ttgcaaaaat cttagctgaa ggaggaatac gagggctttg ggcaggctgg    240

gtacccaata tacaaagagc agcactggtg aatatgggag atttaaccac ttatgataca    300

gtgaaacact acttggtatt gaatacacca cttgaggaca atatcatgac tcacggttta    360

tcaagtgatc tggtcggatc tcacaaggcc atccaatgag accccgcaca gcattttcta    420

aagaagaatc gaagcctgac cactttcacc ttgggcaaga aggtttggcc tttgagttgc    480

tattctatgc tgaagagcct gcttagagga ggagtaccag gagggagcca gcatttcaga    540

tctgaagtag acgataggaa tgtggaagaa cacatacata gtgcttaaga aatacattta    600

acctgttatg tcagtattta tcaatgaagt ttgataattc acttttctgt cattgttaaa    660

gcgtacatac tgtaaattaa agggaggtga atggaaatta atgaataaac attttgagtt    720

tccctagtgt tgaaggaagg tgtacttttt cttgtcagaa agataaaaaa aatcaagttg    780

agatgatgtt tgaatttcaa gaaaagaggc tgctttctgt cagtgccctc tcattagatc    840

tgtgttaatt agttagcact ccactgcaca tgctaatgac ttcctctgac agccacacac    900

cgaatcttga tgaaaaaaga gaagagcatt tgccttgtta catagtctgt tacaagccag    960

atatgttgct agctctcaag agttgtaata tattaagaac tacaacttat ttgattaaaa   1020

ctcagctgta tagatccttt tataaagcac cttttgttaa acatcagcct ttcattggta   1080

ttttaaaagc aaggcagata gatatgaagt cagccaactc tgacatgcgt cctttcttat   1140

ctcccttacc tgacactagg ggctctagag aggcagagag agcactcaca aatcacacta   1200

aaactgccag cggcctgact cttactcagt ttagcaaaaa ttcttgccta aaaagtgata   1260

agtaaaaatc tgtttatggt atacagttat gtctcgaatc tttgaatcaa atccatgttc   1320

ttattttaga aaggtaagag ttcttcaaat tcagctacat accaccggct ctcccaacct   1380

cagacggtgg gcatttctgg atggatggct gcggttatgg ataaaggctg taactgttaa   1440

cacagaaaaa catgaaaagc tcaggcccaa gaaaggcctt ggagccagcc aaacagaatt   1500

tgttctaatg gacatggatg atgttgaaca gaaaaaagtt tacaagtgct ttgtggttgc   1560

actaatgtat actcactgcc attttaagag ggggaagtac attttaaaat atatttgaat   1620

gtcatgtact gatatgcagt agcttattgt ttttctagtt gcagagaatg tgaagtttaa   1680

tctcttaaaa tatttagatg gtctactttt tcattgaatt tgtcaatatg taattgcgtt   1740

gtaaaatatt atatatatat atatatatat atatatatat atatgcttaa cttcccaagt   1800

gttctgcatt gaaccactta gggaaaattt tgtttgtttt tatgttttgt aatttttaaa   1860

attaagtaaa gactggatca aaataattgc atccaacctg gaccgtgaac              1910


<210>  3223
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  3223

Met Met Ala Gly Val Ile Gly Gln Phe Leu Ala Asn Pro Thr Asp Leu 
1               5                   10                  15


Val Lys Val Gln Met Gln Met Glu Gly Lys Arg Lys Leu Glu Gly Lys 
            20                  25                  30


Pro Leu Arg Phe Arg Gly Val His His Ala Phe Ala Lys Ile Leu Ala 
        35                  40                  45


Glu Gly Gly Ile Arg Gly Leu Trp Ala Gly Trp Val Pro Asn Ile Gln 
    50                  55                  60


Arg Ala Ala Leu Val Asn Met Gly Asp Leu Thr Thr Tyr Asp Thr Val 
65                  70                  75                  80


Lys His Tyr Leu Val Leu Asn Thr Pro Leu Glu Asp Asn Ile Met Thr 
                85                  90                  95


His Gly Leu Ser Ser Asp Leu Val Gly Ser His Lys Ala Ile Gln 
            100                 105                 110


<210>  3224
<211>  269
<212>  DNA
<213>  Homo sapiens

<400>  3224
gcccaaggag cttgttggga cgttcaggag accccgaggt gggaggtttt ggacacaacc     60

tgcatctcct cagagcgcct tcgactctgg aggccgccgt gtgacggcct gacacagggc    120

tgcgggagaa catactattt catatcaaat cagattctcc acgttaccta ctcaagtcat    180

aagcgtctga agaaagtgct ctgtaaattc tcagcagaat atgcttttaa caattcttta    240

aaaacaataa agtcataata aaaatcttg                                      269


<210>  3225
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  3225

Ala Gln Gly Ala Cys Trp Asp Val Gln Glu Thr Pro Arg Trp Glu Val 
1               5                   10                  15


Leu Asp Thr Thr Cys Ile Ser Ser Glu Arg Leu Arg Leu Trp Arg Pro 
            20                  25                  30


Pro Cys Asp Gly Leu Thr Gln Gly Cys Gly Arg Thr Tyr Tyr Phe Ile 
        35                  40                  45


Ser Asn Gln Ile Leu His Val Thr Tyr Ser Ser His Lys Arg Leu Lys 
    50                  55                  60


Lys Val Leu Cys Lys Phe Ser Ala Glu Tyr Ala Phe Asn Asn Ser Leu 
65                  70                  75                  80


Lys Thr Ile Lys Ser 
                85


<210>  3226
<211>  379
<212>  DNA
<213>  Homo sapiens

<400>  3226
ccagccgagg cctggggttg gcctaacgcc taagggccca aggagcttgt tgggacgttc     60

aggagacccc gaggtgggag gttttggaca caacctgcat ctcctcagag cgccttcgac    120

tctggaggcc gccgtgtgac ggcctgacac agggctgcgg tgaggaccga ccagagaggg    180

atttcctttt cgtcctccca actaccaggg attgagcact gggggccagg caagggagaa    240

catactattt catatcaaat cagattctcc acgttaccta ctcaagtcat aagcgtctga    300

agaaagtgct ctgtaaattc tcagcagaat atgcttttaa caattcttta aaaacaataa    360

agtcataata aaaatcttg                                                 379


<210>  3227
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  3227

His Arg Ala Ala Val Arg Thr Asp Gln Arg Gly Ile Ser Phe Ser Ser 
1               5                   10                  15


Ser Gln Leu Pro Gly Ile Glu His Trp Gly Pro Gly Lys Gly Glu His 
            20                  25                  30


Thr Ile Ser Tyr Gln Ile Arg Phe Ser Thr Leu Pro Thr Gln Val Ile 
        35                  40                  45


Ser Val 
    50


<210>  3228
<211>  377
<212>  DNA
<213>  Homo sapiens

<400>  3228
aggcccccgg cgccggcatt ccgggcgtcg agcacatctt gacggcgcgg cgcggccccc     60

acttccggaa attaagggcc gcgcctcagg gcctcgaaat cctccgcgcc gcctgaaggc    120

gagtcccagc caaactaggt tcaaaggacc cagtggaggg gaagaatgcc ggcgaggcct    180

tttctcggca actcccccgt cgagggtcct ccgggactcc cgccacggac tgggagaaca    240

tactatttca tatcaaatca gattctccac gttacctact caagtcataa gcgtctgaag    300

aaagtgctct gtaaattctc agcagaatat gcttttaaca attctttaaa aacaataaag    360

tcataataaa aatcttg                                                   377


<210>  3229
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  3229

Met Pro Ala Arg Pro Phe Leu Gly Asn Ser Pro Val Glu Gly Pro Pro 
1               5                   10                  15


Gly Leu Pro Pro Arg Thr Gly Arg Thr Tyr Tyr Phe Ile Ser Asn Gln 
            20                  25                  30


Ile Leu His Val Thr Tyr Ser Ser His Lys Arg Leu Lys Lys Val Leu 
        35                  40                  45


Cys Lys Phe Ser Ala Glu Tyr Ala Phe Asn Asn Ser Leu Lys Thr Ile 
    50                  55                  60


Lys Ser 
65


<210>  3230
<211>  942
<212>  DNA
<213>  Homo sapiens

<400>  3230
gaccccttgg tcaatggtgt tctggcttac ttatgaaaaa atcagagaga tgagtggagt     60

cagtccattt taaaccccta aagatgcaac ccttaaagat acagtgttca gtattattga    120

aatatgggca tctgcaacac atacccccta ttatttctac ctctttagga agacacctat    180

tccacagaga ctgatttata gggggcagca ctttattttt ttctggaaac ccaagttctc    240

tttgactcct ctttttgtcc aaaagtgatc tggtcggatc tcacaaggcc atccaatgag    300

accccgcaca gcattttcta aagaagaatc gaagcctgac cactttcacc ttgggcaaga    360

agaaaggtaa gagttcttca aattcagcta cataccaccg gctctcccaa cctcagacgg    420

tgggcatttc tggatggatg gctgcggtta tggataaagg ctgtaactgt taacacagaa    480

aaacatgaaa agctcaggcc caagaaaggc cttggagcca gccaaacaga atttgttcta    540

atggacatgg atgatgttga acagaaaaaa gtttacaagt gctttgtggt tgcactaatg    600

tatactcact gccattttaa gagggggaag tacattttaa aatatatttg aatgtcatgt    660

actgatatgc agtagcttat tgtttttcta gttgcagaga atgtgaagtt taatctctta    720

aaatatttag atggtctact ttttcattga atttgtcaat atgtaattgc gttgtaaaat    780

attatatata tatatatata tatatatata tatatatgct taacttccca agtgttctgc    840

attgaaccac ttagggaaaa ttttgtttgt ttttatgttt tgtaattttt aaaattaagt    900

aaagactgga tcaaaataat tgcatccaac ctggaccgtg aa                       942


<210>  3231
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  3231

Met Asp Met Asp Asp Val Glu Gln Lys Lys Val Tyr Lys Cys Phe Val 
1               5                   10                  15


Val Ala Leu Met Tyr Thr His Cys His Phe Lys Arg Gly Lys Tyr Ile 
            20                  25                  30


Leu Lys Tyr Ile 
        35


<210>  3232
<211>  6832
<212>  DNA
<213>  Homo sapiens

<400>  3232
atgtgctcga cgcccggaat gccggcgccg ggggcctcgc tggccctgcg ggtgtccttc     60

gtggacgtgc atcccgatgt gatcccggtg cagctgtggg ggctggtggg cgagcggcgg    120

ggcgagtacc tgcggctgag ccgggaaatc caggaagcgg cggccacgcg cggccagtgg    180

gcgctgggca gcgcctcggc ctcgcccggc gagctgtgcc tggtgcaggt cgggcttttg    240

tggcaccgct gccgcgtggt cagccggcag gcacaggaga gccgtgtctt cctgctggac    300

gagggccgca ccatcacggc cggagcaggc tcgctggcgc ctgggcgcag agagttcttc    360

aatttgccct cggaagtgct gggctgcgtg ctagcgggcc tggtgccggc aggctgcggc    420

gcgggctcag gcgagccgcc gcagcactgg cccgccgacg ccgtggactt ccttagcaac    480

cttcagggca aggaggtgca cgggtgcgtc ctggacgtgc tgctgctcca tcgcctggtc    540

ctcctggagg tgcctgatgt gttccaacag atgcgggagc tgggcctggc tcggcgggtg    600

cccgacagcc tcttccgttc gctgctggag cgctatctca cagcggccac tgctagcgtg    660

ggctccgggg tcccggttct ctcgcgagtc ccgctcaagc aaaagcagcc tggtctggat    720

tacttctatc cccagctgca gctgggcgtg acggaggccg tggtcataac ccaagtgtgc    780

catccccacc gcattcactg ccagctccgc agcgtctcgc aggagatcca ccgcctctcc    840

gagagcatgg cccaggtata ccggggttcc acggggacag gggatgagaa ctctaccagt    900

gccacctggg aggagaggga ggagagccca gataagccgg gctctccgtg tgcatcctgt    960

ggcctggatg gacattggta cagagcactg ttgcttgaga cttttcggcc ccagcgctgt   1020

gcccaggtgc ttcatgtgga ctatggaagg aaggagttag tgagttgcag cagccttcgg   1080

tacttgctgc ctgaatattt tcgaatgccg gtggtgacct acccttgtgc tttgtatgga   1140

ctctgggacg gtgggagagg ctggtctcgg tcacaggtcg gtgacctgaa gacactgata   1200

ctaggcaagg cagtgaatgc aaagattgaa ttttattgct cctttgagca tgtgtattat   1260

gtcagcctgt atggagaaga tgggattaat ctgaaccgtg tgtttggagt acagtcgtgt   1320

tgcttggctg accgagtcct tcagagccag gcaacagagg aggaggaacc agaaacatct   1380

cagtctcagt ctcctgctga agaagtagat gaagagattt cactcccagc cttaagatct   1440

atcaggttaa agatgaatgc cttctacgat gcgcaggtag agtttgttaa aaatccttct   1500

gagttttgga ttaggttgag gaaacacaat gtcaccttca gtaagctgat gaggagaatg   1560

tgtggtttct attcctctgc cagtaagctg gatggtgtag ttttgaaacc tgaacctgat   1620

gacctttgct gtgtcaagtg gaaagaaaat ggttattata gggccatagt caccaaattg   1680

gatgacaaga gtgtggatgt attcttagtt gaccgaggca attcggaaaa tgtggactgg   1740

tatgacgtaa ggatgctgct tcctcagttt aggcagctac caatattggc tgtgaagtgc   1800

accctggctg atatttggcc tttgggaaaa acttggagcc aggaggcagt ttcctttttt   1860

aaaaagactg tgctccacaa agaattagtc atccatattc ttgataaaca ggatcatcaa   1920

tatgttattg agattcttga cgaatcaaga acaggggaag aaaacattag taaggtaatt   1980

gcccaagctg gatatgccaa gtatcaggaa tttgaaacaa aggaaaatat cctggtaaat   2040

gcccactccc cagggcatgt ttcaaaccac tttactacgg agagtaacaa aatacctttt   2100

gccaagactg gagaaggaga gcagaaagcc aagagagaga ataaaaccac atctgtttca   2160

aaagctttga gtgacacaac agttgtaaca aatggttcaa ctgaactagt tgtgcaggaa   2220

aaagtgaaaa gagcatctgt ttattttcct cttatgcaga attgcttgga aattaagcca   2280

ggctcctcta gtaaaggaga gctggaagtt ggaagtacag tagaagtcag agtgtcttat   2340

gttgaaaacc ctggctattt ctggtgtcag ctgaccagga acatacaagg acttaaaact   2400

ctaatgtctg atattcagta ctattgcaaa aatacagctg ctcctcacca gagaaacacc   2460

cttgcttgtt tggctaagcg aacagtaaac agacagtggt ccagagcact tattagtggg   2520

atacagtctg tggagcatgt caatgtaaca tttgtagatt atggagacag agaaatggta   2580

tctgtgaaga atatttattc aattagtgaa gaatttctga aggttaaggc acaggctttt   2640

aggtgcagtc tttataattt aattcaacca gttggccaga atccctttgt ttgggatgta   2700

aaggcaatac aagctttcaa tgaatttata gataatgcat ggcaaaaaaa tctagaatta   2760

aaatgtacaa tatttgctct ggcttcaatt aatgaagaac tgtttaacat tgtggatttg   2820

ctaaccccct ttcagagtgc atgccatttc ttggtagaaa agagacttgc aagaccagta   2880

aaacttcaga agcctttgga gtcctctgtt cagctacatt cctacttcta ttctacacat   2940

gatatgaaaa ttggaagtga agaattagtt tatataacgc atattgatga cccttggaca   3000

ttttattgcc agctggcaag aaatgcaaat attttagaac agttgtcatg tagtattaca   3060

caattaagta aagttttgct gaatttaaaa acatctccct tgaaccctgg aaccttgtgc   3120

cttgccaagt atactgatgg aaactggtat aggggcatag taatagagaa agagccaaag   3180

aaagtcttct ttgttgattt tgggaatatt tatgtagtaa caagtgatga tctgcttcca   3240

atacctagtg atgcatatga tgtcttactt ttgcccatgc aagctgtcag atgttcatta   3300

tctgatattc ctgatcatat accagaagaa gtggtggtgt ggtttcagga gactatttta   3360

gataagtcat tgaaggcttt agttgtagca aaagatccag atggaacact gattatagaa   3420

ctatatggtg acaatattca aattagtgct agtattaata agaagttggg gctacttagt   3480

tacaaagata gaataagaaa aaaagaaagt gaagtcctct gttctacaac tgaaactctt   3540

gaagaaaaaa atgagaatat gaagttgcca tgtacagagt atttaagtaa atcagtaggg   3600

tacaagttac ctaataaaga aattttggaa gagtcatata aacctcagat caactcatca   3660

tacaaggaac tcaaactttt acaaagttta acaaaaacaa acttagtcac tcaatatcaa   3720

gactctgtgg gaaataaaaa tagtcaagtg tttccattaa caacagaaaa gaaagaagaa   3780

atttctgctg agacaccctt gaaaacagca agagtagaag ctactctttc agagagaaaa   3840

ataggagatt catgtgacaa agatttgcct ctgaaatttt gtgagttccc acagaagact   3900

ataatgcctg gatttaaaac aactgtatat gtttctcata taaatgacct ttcagacttt   3960

tatgttcaac taatagaaga tgaagctgaa attagtcatc tttcagagag attaaacagt   4020

gttaaaacaa ggcccgaata ttatgtaggt ccacctttgc aaagaggaga tatgatatgt   4080

gctgttttcc cagaagataa tttatggtat cgtgctgtga tcaaggagca acaacccaat   4140

gaccttctct ctgtgcagtt tatagattat ggcaatgttt ctgtggttca tactaacaaa   4200

ataggtaggc ttgaccttgt taatgcaata ttgccggggt tgtgcattca ttgctccttg   4260

cagggatttg aggttcctga caataaaaat tctaagaaaa tgatgcatta cttttcccaa   4320

cggaccagcg aggctgcaat aagatgtgaa tttgttaaat ttcaagacag atgggaagtt   4380

attcttgctg atgaacatgg gatcatagca gatgatatga ttagcaggta tgctctcagt   4440

gaaaaatctc aagtagaact ttctacccaa gtaattaaaa gtgccagttc aaagtctgtt   4500

aacaaatcag acattgacac ttcagtattt cttaactggt ataatccaga aaaaaaaatg   4560

ataagagctt atgccactgt gatagatgga cctgagtact tttggtgtca gtttgctgat   4620

acggagaaac ttcagtgttt agaagtagaa gtacagactg ctggagaaca ggtagcagac   4680

aggagaaatt gtatcccatg tccttatatt ggagatcctt gtatagtaag atacagagaa   4740

gatggacatt attatagggc acttatcact aatatttgtg aagattatct tgtatctgtc   4800

aggcttgtgg actttggaaa cattgaagac tgtgtggacc caaaagcact ctgggccatt   4860

ccttctgaac ttctgtcggt tcccatgcaa gcctttccat gttgcctctc agggtttaac   4920

atttcagaag gattatgttc tcaagaggga aatgactatt tctatgaaat aataacagaa   4980

gatgtgttgg aaataacaat actagaaatc agaagggatg tttgtgatat ccctttagca   5040

attgttgact tgaaaagcaa aggtaaaagt attaatgaga aaatggagaa atattctaag   5100

actggtatta aaagtgctct tccctatgaa aatattgact cagagataaa gcagactctt   5160

gggtcctaca atcttgatgt aggacttaag aaattaagta ataaagctgt acaaaataaa   5220

atatatatgg aacaacagac agatgagctt gctgaaataa ctgaaaaaga tgtaaacatt   5280

attggaacca aaccaagtaa cttccgtgac cctaaaactg ataacatttg tgaagggttt   5340

gaaaacccct gcaaagataa aattgatact gaggaactgg aaggtgaatt agagtgccat   5400

ctggttgaca aagcagagtt tgatgataaa tacctgatta caggatttaa cacattacta   5460

ccacatgcta atgaaacaaa ggagatacta gaactgaatt cacttgaggt gccgctttct   5520

cctgatgatg aatcaaaaga attcttagaa ctggaatcta ttgagttaca gaattctctg   5580

gtggtggatg aagaaaaagg ggagctaagc ccggtgccac cgaatgtgcc actctcccaa   5640

gagtgtgtca caaaaggcgc catggagcta tttacactgc agcttcctct cagctgtgaa   5700

gctgagaaac agccagaact agaactacct acagcccagc tgcctttaga tgacaagatg   5760

gatcctttgt ctttaggagt tagtcagaaa gcacaggaat ccatgtgtac tgaggacatg   5820

agaaagtcaa gttgtgtaga atcttttgat gaccagcgca ggatgtcatt gcatctacat   5880

ggagcagatt gtgatcctaa aacacagaat gaaatgaata tatgtgaaga agaatttgta   5940

gagtataaaa acagggatgc catttcggca ttgatgcctt tgttctctga ggaagaaagc   6000

agtgatggaa gcaagcacaa taatggttta ccagatcata tctcagctca actacagaac   6060

acctacactc tgaaagcctt tactgttgga tctaaatgtg ttgtgtggtc aagtctaaga   6120

aacacatggt ctaaatgtga gattttagaa acagctgaag aaggaacaag ggttttgaac   6180

ctttcaaatg gtatggagga gatagtgaac cctgagaatg tctggaatgg catacccaaa   6240

ttggataaga gtccacctga gaaaaggggt ttggaggtga tggagattta accgtggatc   6300

tatagctgtg gccaatcagt cagaagctgc ccttgaacaa gtggcatctt acgcagacca   6360

acagagtatt tgagaaaatt gaaaacatgt aaccacaaga agttgtcatt ttcaaaaact   6420

tctatatagg tggaaaacaa attaggtctc aggttgatgg tggggtgtgt ttatagtgat   6480

cctgttatat atacagatct gggatctttc gtctttattg tcttacgttt ctaattagtt   6540

gggaggattt attttgctaa acagtttact aacacattac atttcaaaaa ctattttggt   6600

acctttcaaa tacagtgttt aaattaaaat agaaaaataa gggctcatga caagtacatt   6660

atttgattct acttaggata gctttttagc aggatctcct tcagaatttt tgtcttgact   6720

ttgaatcttt gcctgtttgt ctaaacattt gactaacatt ctgtttgaat ttggaagtat   6780

tctaatacaa gatttgaata aagtttatcc ttaaataaag tttatcctta at           6832


<210>  3233
<211>  2096
<212>  PRT
<213>  Homo sapiens

<400>  3233

Met Cys Ser Thr Pro Gly Met Pro Ala Pro Gly Ala Ser Leu Ala Leu 
1               5                   10                  15


Arg Val Ser Phe Val Asp Val His Pro Asp Val Ile Pro Val Gln Leu 
            20                  25                  30


Trp Gly Leu Val Gly Glu Arg Arg Gly Glu Tyr Leu Arg Leu Ser Arg 
        35                  40                  45


Glu Ile Gln Glu Ala Ala Ala Thr Arg Gly Gln Trp Ala Leu Gly Ser 
    50                  55                  60


Ala Ser Ala Ser Pro Gly Glu Leu Cys Leu Val Gln Val Gly Leu Leu 
65                  70                  75                  80


Trp His Arg Cys Arg Val Val Ser Arg Gln Ala Gln Glu Ser Arg Val 
                85                  90                  95


Phe Leu Leu Asp Glu Gly Arg Thr Ile Thr Ala Gly Ala Gly Ser Leu 
            100                 105                 110


Ala Pro Gly Arg Arg Glu Phe Phe Asn Leu Pro Ser Glu Val Leu Gly 
        115                 120                 125


Cys Val Leu Ala Gly Leu Val Pro Ala Gly Cys Gly Ala Gly Ser Gly 
    130                 135                 140


Glu Pro Pro Gln His Trp Pro Ala Asp Ala Val Asp Phe Leu Ser Asn 
145                 150                 155                 160


Leu Gln Gly Lys Glu Val His Gly Cys Val Leu Asp Val Leu Leu Leu 
                165                 170                 175


His Arg Leu Val Leu Leu Glu Val Pro Asp Val Phe Gln Gln Met Arg 
            180                 185                 190


Glu Leu Gly Leu Ala Arg Arg Val Pro Asp Ser Leu Phe Arg Ser Leu 
        195                 200                 205


Leu Glu Arg Tyr Leu Thr Ala Ala Thr Ala Ser Val Gly Ser Gly Val 
    210                 215                 220


Pro Val Leu Ser Arg Val Pro Leu Lys Gln Lys Gln Pro Gly Leu Asp 
225                 230                 235                 240


Tyr Phe Tyr Pro Gln Leu Gln Leu Gly Val Thr Glu Ala Val Val Ile 
                245                 250                 255


Thr Gln Val Cys His Pro His Arg Ile His Cys Gln Leu Arg Ser Val 
            260                 265                 270


Ser Gln Glu Ile His Arg Leu Ser Glu Ser Met Ala Gln Val Tyr Arg 
        275                 280                 285


Gly Ser Thr Gly Thr Gly Asp Glu Asn Ser Thr Ser Ala Thr Trp Glu 
    290                 295                 300


Glu Arg Glu Glu Ser Pro Asp Lys Pro Gly Ser Pro Cys Ala Ser Cys 
305                 310                 315                 320


Gly Leu Asp Gly His Trp Tyr Arg Ala Leu Leu Leu Glu Thr Phe Arg 
                325                 330                 335


Pro Gln Arg Cys Ala Gln Val Leu His Val Asp Tyr Gly Arg Lys Glu 
            340                 345                 350


Leu Val Ser Cys Ser Ser Leu Arg Tyr Leu Leu Pro Glu Tyr Phe Arg 
        355                 360                 365


Met Pro Val Val Thr Tyr Pro Cys Ala Leu Tyr Gly Leu Trp Asp Gly 
    370                 375                 380


Gly Arg Gly Trp Ser Arg Ser Gln Val Gly Asp Leu Lys Thr Leu Ile 
385                 390                 395                 400


Leu Gly Lys Ala Val Asn Ala Lys Ile Glu Phe Tyr Cys Ser Phe Glu 
                405                 410                 415


His Val Tyr Tyr Val Ser Leu Tyr Gly Glu Asp Gly Ile Asn Leu Asn 
            420                 425                 430


Arg Val Phe Gly Val Gln Ser Cys Cys Leu Ala Asp Arg Val Leu Gln 
        435                 440                 445


Ser Gln Ala Thr Glu Glu Glu Glu Pro Glu Thr Ser Gln Ser Gln Ser 
    450                 455                 460


Pro Ala Glu Glu Val Asp Glu Glu Ile Ser Leu Pro Ala Leu Arg Ser 
465                 470                 475                 480


Ile Arg Leu Lys Met Asn Ala Phe Tyr Asp Ala Gln Val Glu Phe Val 
                485                 490                 495


Lys Asn Pro Ser Glu Phe Trp Ile Arg Leu Arg Lys His Asn Val Thr 
            500                 505                 510


Phe Ser Lys Leu Met Arg Arg Met Cys Gly Phe Tyr Ser Ser Ala Ser 
        515                 520                 525


Lys Leu Asp Gly Val Val Leu Lys Pro Glu Pro Asp Asp Leu Cys Cys 
    530                 535                 540


Val Lys Trp Lys Glu Asn Gly Tyr Tyr Arg Ala Ile Val Thr Lys Leu 
545                 550                 555                 560


Asp Asp Lys Ser Val Asp Val Phe Leu Val Asp Arg Gly Asn Ser Glu 
                565                 570                 575


Asn Val Asp Trp Tyr Asp Val Arg Met Leu Leu Pro Gln Phe Arg Gln 
            580                 585                 590


Leu Pro Ile Leu Ala Val Lys Cys Thr Leu Ala Asp Ile Trp Pro Leu 
        595                 600                 605


Gly Lys Thr Trp Ser Gln Glu Ala Val Ser Phe Phe Lys Lys Thr Val 
    610                 615                 620


Leu His Lys Glu Leu Val Ile His Ile Leu Asp Lys Gln Asp His Gln 
625                 630                 635                 640


Tyr Val Ile Glu Ile Leu Asp Glu Ser Arg Thr Gly Glu Glu Asn Ile 
                645                 650                 655


Ser Lys Val Ile Ala Gln Ala Gly Tyr Ala Lys Tyr Gln Glu Phe Glu 
            660                 665                 670


Thr Lys Glu Asn Ile Leu Val Asn Ala His Ser Pro Gly His Val Ser 
        675                 680                 685


Asn His Phe Thr Thr Glu Ser Asn Lys Ile Pro Phe Ala Lys Thr Gly 
    690                 695                 700


Glu Gly Glu Gln Lys Ala Lys Arg Glu Asn Lys Thr Thr Ser Val Ser 
705                 710                 715                 720


Lys Ala Leu Ser Asp Thr Thr Val Val Thr Asn Gly Ser Thr Glu Leu 
                725                 730                 735


Val Val Gln Glu Lys Val Lys Arg Ala Ser Val Tyr Phe Pro Leu Met 
            740                 745                 750


Gln Asn Cys Leu Glu Ile Lys Pro Gly Ser Ser Ser Lys Gly Glu Leu 
        755                 760                 765


Glu Val Gly Ser Thr Val Glu Val Arg Val Ser Tyr Val Glu Asn Pro 
    770                 775                 780


Gly Tyr Phe Trp Cys Gln Leu Thr Arg Asn Ile Gln Gly Leu Lys Thr 
785                 790                 795                 800


Leu Met Ser Asp Ile Gln Tyr Tyr Cys Lys Asn Thr Ala Ala Pro His 
                805                 810                 815


Gln Arg Asn Thr Leu Ala Cys Leu Ala Lys Arg Thr Val Asn Arg Gln 
            820                 825                 830


Trp Ser Arg Ala Leu Ile Ser Gly Ile Gln Ser Val Glu His Val Asn 
        835                 840                 845


Val Thr Phe Val Asp Tyr Gly Asp Arg Glu Met Val Ser Val Lys Asn 
    850                 855                 860


Ile Tyr Ser Ile Ser Glu Glu Phe Leu Lys Val Lys Ala Gln Ala Phe 
865                 870                 875                 880


Arg Cys Ser Leu Tyr Asn Leu Ile Gln Pro Val Gly Gln Asn Pro Phe 
                885                 890                 895


Val Trp Asp Val Lys Ala Ile Gln Ala Phe Asn Glu Phe Ile Asp Asn 
            900                 905                 910


Ala Trp Gln Lys Asn Leu Glu Leu Lys Cys Thr Ile Phe Ala Leu Ala 
        915                 920                 925


Ser Ile Asn Glu Glu Leu Phe Asn Ile Val Asp Leu Leu Thr Pro Phe 
    930                 935                 940


Gln Ser Ala Cys His Phe Leu Val Glu Lys Arg Leu Ala Arg Pro Val 
945                 950                 955                 960


Lys Leu Gln Lys Pro Leu Glu Ser Ser Val Gln Leu His Ser Tyr Phe 
                965                 970                 975


Tyr Ser Thr His Asp Met Lys Ile Gly Ser Glu Glu Leu Val Tyr Ile 
            980                 985                 990


Thr His Ile Asp Asp Pro Trp Thr Phe Tyr Cys Gln Leu Ala Arg Asn 
        995                 1000                1005


Ala Asn Ile Leu Glu Gln Leu Ser Cys Ser Ile Thr Gln Leu Ser Lys 
    1010                1015                1020


Val Leu Leu Asn Leu Lys Thr Ser Pro Leu Asn Pro Gly Thr Leu Cys 
1025                1030                1035                1040


Leu Ala Lys Tyr Thr Asp Gly Asn Trp Tyr Arg Gly Ile Val Ile Glu 
                1045                1050                1055


Lys Glu Pro Lys Lys Val Phe Phe Val Asp Phe Gly Asn Ile Tyr Val 
            1060                1065                1070


Val Thr Ser Asp Asp Leu Leu Pro Ile Pro Ser Asp Ala Tyr Asp Val 
        1075                1080                1085


Leu Leu Leu Pro Met Gln Ala Val Arg Cys Ser Leu Ser Asp Ile Pro 
    1090                1095                1100


Asp His Ile Pro Glu Glu Val Val Val Trp Phe Gln Glu Thr Ile Leu 
1105                1110                1115                1120


Asp Lys Ser Leu Lys Ala Leu Val Val Ala Lys Asp Pro Asp Gly Thr 
                1125                1130                1135


Leu Ile Ile Glu Leu Tyr Gly Asp Asn Ile Gln Ile Ser Ala Ser Ile 
            1140                1145                1150


Asn Lys Lys Leu Gly Leu Leu Ser Tyr Lys Asp Arg Ile Arg Lys Lys 
        1155                1160                1165


Glu Ser Glu Val Leu Cys Ser Thr Thr Glu Thr Leu Glu Glu Lys Asn 
    1170                1175                1180


Glu Asn Met Lys Leu Pro Cys Thr Glu Tyr Leu Ser Lys Ser Val Gly 
1185                1190                1195                1200


Tyr Lys Leu Pro Asn Lys Glu Ile Leu Glu Glu Ser Tyr Lys Pro Gln 
                1205                1210                1215


Ile Asn Ser Ser Tyr Lys Glu Leu Lys Leu Leu Gln Ser Leu Thr Lys 
            1220                1225                1230


Thr Asn Leu Val Thr Gln Tyr Gln Asp Ser Val Gly Asn Lys Asn Ser 
        1235                1240                1245


Gln Val Phe Pro Leu Thr Thr Glu Lys Lys Glu Glu Ile Ser Ala Glu 
    1250                1255                1260


Thr Pro Leu Lys Thr Ala Arg Val Glu Ala Thr Leu Ser Glu Arg Lys 
1265                1270                1275                1280


Ile Gly Asp Ser Cys Asp Lys Asp Leu Pro Leu Lys Phe Cys Glu Phe 
                1285                1290                1295


Pro Gln Lys Thr Ile Met Pro Gly Phe Lys Thr Thr Val Tyr Val Ser 
            1300                1305                1310


His Ile Asn Asp Leu Ser Asp Phe Tyr Val Gln Leu Ile Glu Asp Glu 
        1315                1320                1325


Ala Glu Ile Ser His Leu Ser Glu Arg Leu Asn Ser Val Lys Thr Arg 
    1330                1335                1340


Pro Glu Tyr Tyr Val Gly Pro Pro Leu Gln Arg Gly Asp Met Ile Cys 
1345                1350                1355                1360


Ala Val Phe Pro Glu Asp Asn Leu Trp Tyr Arg Ala Val Ile Lys Glu 
                1365                1370                1375


Gln Gln Pro Asn Asp Leu Leu Ser Val Gln Phe Ile Asp Tyr Gly Asn 
            1380                1385                1390


Val Ser Val Val His Thr Asn Lys Ile Gly Arg Leu Asp Leu Val Asn 
        1395                1400                1405


Ala Ile Leu Pro Gly Leu Cys Ile His Cys Ser Leu Gln Gly Phe Glu 
    1410                1415                1420


Val Pro Asp Asn Lys Asn Ser Lys Lys Met Met His Tyr Phe Ser Gln 
1425                1430                1435                1440


Arg Thr Ser Glu Ala Ala Ile Arg Cys Glu Phe Val Lys Phe Gln Asp 
                1445                1450                1455


Arg Trp Glu Val Ile Leu Ala Asp Glu His Gly Ile Ile Ala Asp Asp 
            1460                1465                1470


Met Ile Ser Arg Tyr Ala Leu Ser Glu Lys Ser Gln Val Glu Leu Ser 
        1475                1480                1485


Thr Gln Val Ile Lys Ser Ala Ser Ser Lys Ser Val Asn Lys Ser Asp 
    1490                1495                1500


Ile Asp Thr Ser Val Phe Leu Asn Trp Tyr Asn Pro Glu Lys Lys Met 
1505                1510                1515                1520


Ile Arg Ala Tyr Ala Thr Val Ile Asp Gly Pro Glu Tyr Phe Trp Cys 
                1525                1530                1535


Gln Phe Ala Asp Thr Glu Lys Leu Gln Cys Leu Glu Val Glu Val Gln 
            1540                1545                1550


Thr Ala Gly Glu Gln Val Ala Asp Arg Arg Asn Cys Ile Pro Cys Pro 
        1555                1560                1565


Tyr Ile Gly Asp Pro Cys Ile Val Arg Tyr Arg Glu Asp Gly His Tyr 
    1570                1575                1580


Tyr Arg Ala Leu Ile Thr Asn Ile Cys Glu Asp Tyr Leu Val Ser Val 
1585                1590                1595                1600


Arg Leu Val Asp Phe Gly Asn Ile Glu Asp Cys Val Asp Pro Lys Ala 
                1605                1610                1615


Leu Trp Ala Ile Pro Ser Glu Leu Leu Ser Val Pro Met Gln Ala Phe 
            1620                1625                1630


Pro Cys Cys Leu Ser Gly Phe Asn Ile Ser Glu Gly Leu Cys Ser Gln 
        1635                1640                1645


Glu Gly Asn Asp Tyr Phe Tyr Glu Ile Ile Thr Glu Asp Val Leu Glu 
    1650                1655                1660


Ile Thr Ile Leu Glu Ile Arg Arg Asp Val Cys Asp Ile Pro Leu Ala 
1665                1670                1675                1680


Ile Val Asp Leu Lys Ser Lys Gly Lys Ser Ile Asn Glu Lys Met Glu 
                1685                1690                1695


Lys Tyr Ser Lys Thr Gly Ile Lys Ser Ala Leu Pro Tyr Glu Asn Ile 
            1700                1705                1710


Asp Ser Glu Ile Lys Gln Thr Leu Gly Ser Tyr Asn Leu Asp Val Gly 
        1715                1720                1725


Leu Lys Lys Leu Ser Asn Lys Ala Val Gln Asn Lys Ile Tyr Met Glu 
    1730                1735                1740


Gln Gln Thr Asp Glu Leu Ala Glu Ile Thr Glu Lys Asp Val Asn Ile 
1745                1750                1755                1760


Ile Gly Thr Lys Pro Ser Asn Phe Arg Asp Pro Lys Thr Asp Asn Ile 
                1765                1770                1775


Cys Glu Gly Phe Glu Asn Pro Cys Lys Asp Lys Ile Asp Thr Glu Glu 
            1780                1785                1790


Leu Glu Gly Glu Leu Glu Cys His Leu Val Asp Lys Ala Glu Phe Asp 
        1795                1800                1805


Asp Lys Tyr Leu Ile Thr Gly Phe Asn Thr Leu Leu Pro His Ala Asn 
    1810                1815                1820


Glu Thr Lys Glu Ile Leu Glu Leu Asn Ser Leu Glu Val Pro Leu Ser 
1825                1830                1835                1840


Pro Asp Asp Glu Ser Lys Glu Phe Leu Glu Leu Glu Ser Ile Glu Leu 
                1845                1850                1855


Gln Asn Ser Leu Val Val Asp Glu Glu Lys Gly Glu Leu Ser Pro Val 
            1860                1865                1870


Pro Pro Asn Val Pro Leu Ser Gln Glu Cys Val Thr Lys Gly Ala Met 
        1875                1880                1885


Glu Leu Phe Thr Leu Gln Leu Pro Leu Ser Cys Glu Ala Glu Lys Gln 
    1890                1895                1900


Pro Glu Leu Glu Leu Pro Thr Ala Gln Leu Pro Leu Asp Asp Lys Met 
1905                1910                1915                1920


Asp Pro Leu Ser Leu Gly Val Ser Gln Lys Ala Gln Glu Ser Met Cys 
                1925                1930                1935


Thr Glu Asp Met Arg Lys Ser Ser Cys Val Glu Ser Phe Asp Asp Gln 
            1940                1945                1950


Arg Arg Met Ser Leu His Leu His Gly Ala Asp Cys Asp Pro Lys Thr 
        1955                1960                1965


Gln Asn Glu Met Asn Ile Cys Glu Glu Glu Phe Val Glu Tyr Lys Asn 
    1970                1975                1980


Arg Asp Ala Ile Ser Ala Leu Met Pro Leu Phe Ser Glu Glu Glu Ser 
1985                1990                1995                2000


Ser Asp Gly Ser Lys His Asn Asn Gly Leu Pro Asp His Ile Ser Ala 
                2005                2010                2015


Gln Leu Gln Asn Thr Tyr Thr Leu Lys Ala Phe Thr Val Gly Ser Lys 
            2020                2025                2030


Cys Val Val Trp Ser Ser Leu Arg Asn Thr Trp Ser Lys Cys Glu Ile 
        2035                2040                2045


Leu Glu Thr Ala Glu Glu Gly Thr Arg Val Leu Asn Leu Ser Asn Gly 
    2050                2055                2060


Met Glu Glu Ile Val Asn Pro Glu Asn Val Trp Asn Gly Ile Pro Lys 
2065                2070                2075                2080


Leu Asp Lys Ser Pro Pro Glu Lys Arg Gly Leu Glu Val Met Glu Ile 
                2085                2090                2095


<210>  3234
<211>  8721
<212>  DNA
<213>  Homo sapiens

<400>  3234
atgtgctcga cgcccggaat gccggcgccg ggggcctcgc tggccctgcg ggtgtccttc     60

gtggacgtgc atcccgatgt gatcccggtg cagctgtggg ggctggtggg cgagcggcgg    120

ggcgagtacc tgcggctgag ccgggaaatc caggaagcgg cggccacgcg cggccagtgg    180

gcgctgggca gcgcctcggc ctcgcccggc gagctgtgcc tggtgcaggt cgggcttttg    240

tggcaccgct gccgcgtggt cagccggcag gcacaggaga gccgtgtctt cctgctggac    300

gagggccgca ccatcacggc cggagcaggc tcgctggcgc ctgggcgcag agagttcttc    360

aatttgccct cggaagtgct gggctgcgtg ctagcgggcc tggtgccggc aggctgcggc    420

gcgggctcag gcgagccgcc gcagcactgg cccgccgacg ccgtggactt ccttagcaac    480

cttcagggca aggaggtgca cgggtgcgtc ctggacgtgc tgctgctcca tcgcctggtc    540

ctcctggagg tgcctgatgt gttccaacag atgcgggagc tgggcctggc tcggcgggtg    600

cccgacagcc tcttccgttc gctgctggag cgctatctca cagcggccac tgctagcgtg    660

ggctccgggg tcccggttct ctcgcgagtc ccgctcaagc aaaagcagcc tggtctggat    720

tacttctatc cccagctgca gctgggcgtg acggaggccg tggtcataac ccaagtgtgc    780

catccccacc gcattcactg ccagctccgc agcgtctcgc aggagatcca ccgcctctcc    840

gagagcatgg cccaggtata ccggggttcc acggggacag gggatgagaa ctctaccagt    900

gccacctggg aggagaggga ggagagccca gataagccgg gctctccgtg tgcatcctgt    960

ggcctggatg gacattggta cagagcactg ttgcttgaga cttttcggcc ccagcgctgt   1020

gcccaggtgc ttcatgtgga ctatggaagg aaggagttag tgagttgcag cagccttcgg   1080

tacttgctgc ctgaatattt tcgaatgccg gtggtgacct acccttgtgc tttgtatgga   1140

ctctgggacg gtgggagagg ctggtctcgg tcacaggtcg gtgacctgaa gacactgata   1200

ctaggcaagg cagtgaatgc aaagattgaa ttttattgct cctttgagca tgtgtattat   1260

gtcagcctgt atggagaaga tgggattaat ctgaaccgtg tgtttggagt acagtcgtgt   1320

tgcttggctg accgagtcct tcagagccag gcaacagagg aggaggaacc agaaacatct   1380

cagtctcagt ctcctgctga agaagtagat gaagagattt cactcccagc cttaagatct   1440

atcaggttaa agatgaatgc cttctacgat gcgcaggtag agtttgttaa aaatccttct   1500

gagttttgga ttaggttgag gaaacacaat gtcaccttca gtaagctgat gaggagaatg   1560

tgtggtttct attcctctgc cagtaagctg gatggtgtag ttttgaaacc tgaacctgat   1620

gacctttgct gtgtcaagtg gaaagaaaat ggttattata gggccatagt caccaaattg   1680

gatgacaaga gtgtggatgt attcttagtt gaccgaggca attcggaaaa tgtggactgg   1740

tatgacgtaa ggatgctgct tcctcagttt aggcagctac caatattggc tgtgaagtgc   1800

accctggctg atatttggcc tttgggaaaa acttggagcc aggaggcagt ttcctttttt   1860

aaaaagactg tgctccacaa agaattagtc atccatattc ttgataaaca ggatcatcaa   1920

tatgttattg agattcttga cgaatcaaga acaggggaag aaaacattag taaggtaatt   1980

gcccaagctg gatatgccaa gtatcaggaa tttgaaacaa aggaaaatat cctggtaaat   2040

gcccactccc cagggcatgt ttcaaaccac tttactacgg agagtaacaa aatacctttt   2100

gccaagactg gagaaggaga gcagaaagcc aagagagaga ataaaaccac atctgtttca   2160

aaagctttga gtgacacaac agttgtaaca aatggttcaa ctgaactagt tgtgcaggaa   2220

aaagtgaaaa gagcatctgt ttattttcct cttatgcaga attgcttgga aattaagcca   2280

ggctcctcta gtaaaggaga gctggaagtt ggaagtacag tagaagtcag agtgtcttat   2340

gttgaaaacc ctggctattt ctggtgtcag ctgaccagga acatacaagg acttaaaact   2400

ctaatgtctg atattcagta ctattgcaaa aatacagctg ctcctcacca gagaaacacc   2460

cttgcttgtt tggctaagcg aacagtaaac agacagtggt ccagagcact tattagtggg   2520

atacagtctg tggagcatgt caatgtaaca tttgtagatt atggagacag agaaatggta   2580

tctgtgaaga atatttattc aattagtgaa gaatttctga aggttaaggc acaggctttt   2640

aggtgcagtc tttataattt aattcaacca gttggccaga atccctttgt ttgggatgta   2700

aaggcaatac aagctttcaa tgaatttata gataatgcat ggcaaaaaaa tctagaatta   2760

aaatgtacaa tatttgctct ggcttcaatt aatgaagaac tgtttaacat tgtggatttg   2820

ctaaccccct ttcagagtgc atgccatttc ttggtagaaa agagacttgc aagaccagta   2880

aaacttcaga agcctttgga gtcctctgtt cagctacatt cctacttcta ttctacacat   2940

gatatgaaaa ttggaagtga agaattagtt tatataacgc atattgatga cccttggaca   3000

ttttattgcc agctggcaag aaatgcaaat attttagaac agttgtcatg tagtattaca   3060

caattaagta aagttttgct gaatttaaaa acatctccct tgaaccctgg aaccttgtgc   3120

cttgccaagt atactgatgg aaactggtat aggggcatag taatagagaa agagccaaag   3180

aaagtcttct ttgttgattt tgggaatatt tatgtagtaa caagtgatga tctgcttcca   3240

atacctagtg atgcatatga tgtcttactt ttgcccatgc aagctgtcag atgttcatta   3300

tctgatattc ctgatcatat accagaagaa gtggtggtgt ggtttcagga gactatttta   3360

gataagtcat tgaaggcttt agttgtagca aaagatccag atggaacact gattatagaa   3420

ctatatggtg acaatattca aattagtgct agtattaata agaagttggg gctacttagt   3480

tacaaagata gaataagaaa aaaagaaagt gaagtcctct gttctacaac tgaaactctt   3540

gaagaaaaaa atgagaatat gaagttgcca tgtacagagt atttaagtaa atcagtaggg   3600

tacaagttac ctaataaaga aattttggaa gagtcatata aacctcagat caactcatca   3660

tacaaggaac tcaaactttt acaaagttta acaaaaacaa acttagtcac tcaatatcaa   3720

gactctgtgg gaaataaaaa tagtcaagtg tttccattaa caacagaaaa gaaagaagaa   3780

atttctgctg agacaccctt gaaaacagca agagtagaag ctactctttc agagagaaaa   3840

ataggagatt catgtgacaa agatttgcct ctgaaatttt gtgagttccc acagaagact   3900

ataatgcctg gatttaaaac aactgtatat gtttctcata taaatgacct ttcagacttt   3960

tatgttcaac taatagaaga tgaagctgaa attagtcatc tttcagagag attaaacagt   4020

gttaaaacaa ggcccgaata ttatgtaggt ccacctttgc aaagaggaga tatgatatgt   4080

gctgttttcc cagaagataa tttatggtat cgtgctgtga tcaaggagca acaacccaat   4140

gaccttctct ctgtgcagtt tatagattat ggcaatgttt ctgtggttca tactaacaaa   4200

ataggtaggc ttgaccttgt taatgcaata ttgccggggt tgtgcattca ttgctccttg   4260

cagggatttg aggttcctga caataaaaat tctaagaaaa tgatgcatta cttttcccaa   4320

cggaccagcg aggctgcaat aagatgtgaa tttgttaaat ttcaagacag atgggaagtt   4380

attcttgctg atgaacatgg gatcatagca gatgatatga ttagcaggta tgctctcagt   4440

gaaaaatctc aagtagaact ttctacccaa gtaattaaaa gtgccagttc aaagtctgtt   4500

aacaaatcag acattgacac ttcagtattt cttaactggt ataatccaga aaaaaaaatg   4560

ataagagctt atgccactgt gatagatgga cctgagtact tttggtgtca gtttgctgat   4620

acggagaaac ttcagtgttt agaagtagaa gtacagactg ctggagaaca ggtagcagac   4680

aggagaaatt gtatcccatg tccttatatt ggagatcctt gtatagtaag atacagagaa   4740

gatggacatt attatagggc acttatcact aatatttgtg aagattatct tgtatctgtc   4800

aggcttgtgg actttggaaa cattgaagac tgtgtggacc caaaagcact ctgggccatt   4860

ccttctgaac ttctgtcggt tcccatgcaa gcctttccat gttgcctctc agggtttaac   4920

atttcagaag gattatgttc tcaagaggga aatgactatt tctatgaaat aataacagaa   4980

gatgtgttgg aaataacaat actagaaatc agaagggatg tttgtgatat ccctttagca   5040

attgttgact tgaaaagcaa aggtaaaagt attaatgaga aaatggagaa atattctaag   5100

actggtatta aaagtgctct tccctatgaa aatattgact cagagataaa gcagactctt   5160

gggtcctaca atcttgatgt aggacttaag aaattaagta ataaagctgt acaaaataaa   5220

atatatatgg aacaacagac agatgagctt gctgaaataa ctgaaaaaga tgtaaacatt   5280

attggaacca aaccaagtaa cttccgtgac cctaaaactg ataacatttg tgaagggttt   5340

gaaaacccct gcaaagataa aattgatact gaggaactgg aaggtgaatt agagtgccat   5400

ctggttgaca aagcagagtt tgatgataaa tacctgatta caggatttaa cacattacta   5460

ccacatgcta atgaaacaaa ggagatacta gaactgaatt cacttgaggt gccgctttct   5520

cctgatgatg aatcaaaaga attcttagaa ctggaatcta ttgagttaca gaattctctg   5580

gtggtggatg aagaaaaagg ggagctaagc ccggtgccac cgaatgtgcc actctcccaa   5640

gagtgtgtca caaaaggcgc catggagcta tttacactgc agcttcctct cagctgtgaa   5700

gctgagaaac agccagaact agaactacct acagcccagc tgcctttaga tgacaagatg   5760

gatcctttgt ctttaggagt tagtcagaaa gcacaggaat ccatgtgtac tgaggacatg   5820

agaaagtcaa gttgtgtaga atcttttgat gaccagcgca ggatgtcatt gcatctacat   5880

ggagcagatt gtgatcctaa aacacagaat gaaatgaata tatgtgaaga agaatttgta   5940

gagtataaaa acagggatgc catttcggca ttgatgcctt tgttctctga ggaagaaagc   6000

agtgatggaa gcaagcacaa taatggttta ccagatcata tctcagctca actacagaac   6060

acctacactc tgaaagcctt tactgttgga tctaaatgtg ttgtgtggtc aagtctaaga   6120

aacacatggt ctaaatgtga gattttagaa acagctgaag aaggaacaag ggttttgaac   6180

ctttcaaatg gtatggagga gatagtgaac cctgagaatg tctggaatgg catacccaaa   6240

ttggataaga gtccacctga gaaaaggggt ttggaggtga tggagattta accgtggatc   6300

tatagctgtg gccaatcagt cagaagctgc ccttgaacaa gtggcatctt acgcagacca   6360

acagagtatt tgagaaaatt gaaaacatgt aaccacaaga agttgtcatt ttcaaaaact   6420

tctatatagg tggaaaacaa attaggtctc aggttgatgg tggggtgtgt ttatagtgat   6480

cctgttatat atacagatct gggatctttc gtctttattg tcttacgttt ctaattagtt   6540

gggaggattt attttgctaa acagtttact aacacattac atttcaaaaa ctattttggt   6600

acctttcaaa tacagtgttt aaattaaaat agaaaaataa gggctcatga caagtacatt   6660

atttgattct acttaggata gctttttagc aggatctcct tcagaatttt tgtcttgact   6720

ttgaatcttt gcctgtttgt ctaaacattt gactaacatt ctgtttgaat ttggaagtat   6780

tctaatacaa gatttgaata aagtttatcc ttaaataaag tttatcctta atatgatggt   6840

ctcattttat taaaaaggaa atagaactct taaatatact tggttccatc tctcctctgt   6900

aatggaggat tggggaaagc atagtaatat taaatgttag ctcttatgta ttagtcactt   6960

agcttatact ttaaatgcat tttttcactt tattcatcaa ctttgaagtg catatcaata   7020

ttatccatat tttataggtg agaaaattga agcttcataa agaggttaaa taacttgcct   7080

aaggtcagat agctgatgag tctcagaggc ttgatcaaac ccagacctac ctaactttga   7140

agcccatgac tttttaaaca tgattttgca aagcatagat cttagctttt agaaacagat   7200

ctgagctata tgctgcttaa cagatatgtg acatgggcaa attatgtaat attttgaact   7260

ttgatcttca tctgtaaagt ggtgataata aaacctttct tgcagtgttt ttttaagatg   7320

agaaataatt gatataaagt ccctgaaaag gagtaggcat ttgataaatg tgtctttctt   7380

taccctgaaa aatactcagt gtgcactatg ttaggttatt tctttttaac cttaacttat   7440

tagatatttt caatagttat tttctccttt cagcatcagc atgcgccacc aacaaaagac   7500

tgtaaaaaac aaacaaacaa aaaagtgttg aatgggacat ccatacagtt ggaatgctta   7560

tttctaaaat gaatagggaa aaggtttgct aaatgagact ggggtaaagg tgtatctctg   7620

tgaagcatta tcagactctg aagcctaatg gaaatagaat tatgaacctt aaaaacccat   7680

tataatttcc gtaagtagaa gggagagagg tttgcattaa aagtaattga ggtagatgag   7740

tatattactt attcctggaa taatgaatag acaagtttgg cttactcata tagataatat   7800

aatgtgaatt gccagaagca aagctcagag aagatgcatt aggatcagat tataggaagc   7860

cttcaatttc aagctgagtt taactcccta ttttaaaaaa tttaatctga atggctacag   7920

aagtaaaatt tctcagaatg agtgactttg cacctgacac cactaagata ggactagggt   7980

accaaatgag tggtataaat ttttatgtcc cctgggaaat aaaatcattt tccatgattc   8040

ccatatttat aagtataaat tcttaagcta tatttttacc tccatttaat cgtgttattc   8100

tgttttacta ctacatatag aattgaaaac attaaataaa attaactgga atatgaagaa   8160

gctaaatgta attctgaatg ttttattatc cttcacagcc tttgtgtgag taactaatgt   8220

attctaactg gaatccctgc tatatgctgt aatacctgtg gaacctttct ttagcaagta   8280

gaatgcctta aagaattaaa gaaagtgtca aaaaattacc aatttaatcc actgcctttg   8340

cctcatctct aatattctta acccttctct actcctttta gtcatcattt gaaattgtgt   8400

agtaccacca atcctgtgct gaaacaatgg cttttgcttg ttctaatttt tcttaccgtg   8460

accaaaagtc aaagagaaga gctgccaaat tctacctaga atatcatgtt gctataatta   8520

aactccactg cccatagtag ataataaaag gcaagaaatt gttttttact ctatgtttag   8580

ggagtcttgt atcattgcaa caggttttca ctgggatttt gcctgtttta atctacttgt   8640

ctgtcaaagt aatgtaaaaa cagtttttaa cttcgacact gaaaaggaat catctttaaa   8700

attaaaattt aggctgatat g                                             8721


<210>  3235
<211>  2096
<212>  PRT
<213>  Homo sapiens

<400>  3235

Met Cys Ser Thr Pro Gly Met Pro Ala Pro Gly Ala Ser Leu Ala Leu 
1               5                   10                  15


Arg Val Ser Phe Val Asp Val His Pro Asp Val Ile Pro Val Gln Leu 
            20                  25                  30


Trp Gly Leu Val Gly Glu Arg Arg Gly Glu Tyr Leu Arg Leu Ser Arg 
        35                  40                  45


Glu Ile Gln Glu Ala Ala Ala Thr Arg Gly Gln Trp Ala Leu Gly Ser 
    50                  55                  60


Ala Ser Ala Ser Pro Gly Glu Leu Cys Leu Val Gln Val Gly Leu Leu 
65                  70                  75                  80


Trp His Arg Cys Arg Val Val Ser Arg Gln Ala Gln Glu Ser Arg Val 
                85                  90                  95


Phe Leu Leu Asp Glu Gly Arg Thr Ile Thr Ala Gly Ala Gly Ser Leu 
            100                 105                 110


Ala Pro Gly Arg Arg Glu Phe Phe Asn Leu Pro Ser Glu Val Leu Gly 
        115                 120                 125


Cys Val Leu Ala Gly Leu Val Pro Ala Gly Cys Gly Ala Gly Ser Gly 
    130                 135                 140


Glu Pro Pro Gln His Trp Pro Ala Asp Ala Val Asp Phe Leu Ser Asn 
145                 150                 155                 160


Leu Gln Gly Lys Glu Val His Gly Cys Val Leu Asp Val Leu Leu Leu 
                165                 170                 175


His Arg Leu Val Leu Leu Glu Val Pro Asp Val Phe Gln Gln Met Arg 
            180                 185                 190


Glu Leu Gly Leu Ala Arg Arg Val Pro Asp Ser Leu Phe Arg Ser Leu 
        195                 200                 205


Leu Glu Arg Tyr Leu Thr Ala Ala Thr Ala Ser Val Gly Ser Gly Val 
    210                 215                 220


Pro Val Leu Ser Arg Val Pro Leu Lys Gln Lys Gln Pro Gly Leu Asp 
225                 230                 235                 240


Tyr Phe Tyr Pro Gln Leu Gln Leu Gly Val Thr Glu Ala Val Val Ile 
                245                 250                 255


Thr Gln Val Cys His Pro His Arg Ile His Cys Gln Leu Arg Ser Val 
            260                 265                 270


Ser Gln Glu Ile His Arg Leu Ser Glu Ser Met Ala Gln Val Tyr Arg 
        275                 280                 285


Gly Ser Thr Gly Thr Gly Asp Glu Asn Ser Thr Ser Ala Thr Trp Glu 
    290                 295                 300


Glu Arg Glu Glu Ser Pro Asp Lys Pro Gly Ser Pro Cys Ala Ser Cys 
305                 310                 315                 320


Gly Leu Asp Gly His Trp Tyr Arg Ala Leu Leu Leu Glu Thr Phe Arg 
                325                 330                 335


Pro Gln Arg Cys Ala Gln Val Leu His Val Asp Tyr Gly Arg Lys Glu 
            340                 345                 350


Leu Val Ser Cys Ser Ser Leu Arg Tyr Leu Leu Pro Glu Tyr Phe Arg 
        355                 360                 365


Met Pro Val Val Thr Tyr Pro Cys Ala Leu Tyr Gly Leu Trp Asp Gly 
    370                 375                 380


Gly Arg Gly Trp Ser Arg Ser Gln Val Gly Asp Leu Lys Thr Leu Ile 
385                 390                 395                 400


Leu Gly Lys Ala Val Asn Ala Lys Ile Glu Phe Tyr Cys Ser Phe Glu 
                405                 410                 415


His Val Tyr Tyr Val Ser Leu Tyr Gly Glu Asp Gly Ile Asn Leu Asn 
            420                 425                 430


Arg Val Phe Gly Val Gln Ser Cys Cys Leu Ala Asp Arg Val Leu Gln 
        435                 440                 445


Ser Gln Ala Thr Glu Glu Glu Glu Pro Glu Thr Ser Gln Ser Gln Ser 
    450                 455                 460


Pro Ala Glu Glu Val Asp Glu Glu Ile Ser Leu Pro Ala Leu Arg Ser 
465                 470                 475                 480


Ile Arg Leu Lys Met Asn Ala Phe Tyr Asp Ala Gln Val Glu Phe Val 
                485                 490                 495


Lys Asn Pro Ser Glu Phe Trp Ile Arg Leu Arg Lys His Asn Val Thr 
            500                 505                 510


Phe Ser Lys Leu Met Arg Arg Met Cys Gly Phe Tyr Ser Ser Ala Ser 
        515                 520                 525


Lys Leu Asp Gly Val Val Leu Lys Pro Glu Pro Asp Asp Leu Cys Cys 
    530                 535                 540


Val Lys Trp Lys Glu Asn Gly Tyr Tyr Arg Ala Ile Val Thr Lys Leu 
545                 550                 555                 560


Asp Asp Lys Ser Val Asp Val Phe Leu Val Asp Arg Gly Asn Ser Glu 
                565                 570                 575


Asn Val Asp Trp Tyr Asp Val Arg Met Leu Leu Pro Gln Phe Arg Gln 
            580                 585                 590


Leu Pro Ile Leu Ala Val Lys Cys Thr Leu Ala Asp Ile Trp Pro Leu 
        595                 600                 605


Gly Lys Thr Trp Ser Gln Glu Ala Val Ser Phe Phe Lys Lys Thr Val 
    610                 615                 620


Leu His Lys Glu Leu Val Ile His Ile Leu Asp Lys Gln Asp His Gln 
625                 630                 635                 640


Tyr Val Ile Glu Ile Leu Asp Glu Ser Arg Thr Gly Glu Glu Asn Ile 
                645                 650                 655


Ser Lys Val Ile Ala Gln Ala Gly Tyr Ala Lys Tyr Gln Glu Phe Glu 
            660                 665                 670


Thr Lys Glu Asn Ile Leu Val Asn Ala His Ser Pro Gly His Val Ser 
        675                 680                 685


Asn His Phe Thr Thr Glu Ser Asn Lys Ile Pro Phe Ala Lys Thr Gly 
    690                 695                 700


Glu Gly Glu Gln Lys Ala Lys Arg Glu Asn Lys Thr Thr Ser Val Ser 
705                 710                 715                 720


Lys Ala Leu Ser Asp Thr Thr Val Val Thr Asn Gly Ser Thr Glu Leu 
                725                 730                 735


Val Val Gln Glu Lys Val Lys Arg Ala Ser Val Tyr Phe Pro Leu Met 
            740                 745                 750


Gln Asn Cys Leu Glu Ile Lys Pro Gly Ser Ser Ser Lys Gly Glu Leu 
        755                 760                 765


Glu Val Gly Ser Thr Val Glu Val Arg Val Ser Tyr Val Glu Asn Pro 
    770                 775                 780


Gly Tyr Phe Trp Cys Gln Leu Thr Arg Asn Ile Gln Gly Leu Lys Thr 
785                 790                 795                 800


Leu Met Ser Asp Ile Gln Tyr Tyr Cys Lys Asn Thr Ala Ala Pro His 
                805                 810                 815


Gln Arg Asn Thr Leu Ala Cys Leu Ala Lys Arg Thr Val Asn Arg Gln 
            820                 825                 830


Trp Ser Arg Ala Leu Ile Ser Gly Ile Gln Ser Val Glu His Val Asn 
        835                 840                 845


Val Thr Phe Val Asp Tyr Gly Asp Arg Glu Met Val Ser Val Lys Asn 
    850                 855                 860


Ile Tyr Ser Ile Ser Glu Glu Phe Leu Lys Val Lys Ala Gln Ala Phe 
865                 870                 875                 880


Arg Cys Ser Leu Tyr Asn Leu Ile Gln Pro Val Gly Gln Asn Pro Phe 
                885                 890                 895


Val Trp Asp Val Lys Ala Ile Gln Ala Phe Asn Glu Phe Ile Asp Asn 
            900                 905                 910


Ala Trp Gln Lys Asn Leu Glu Leu Lys Cys Thr Ile Phe Ala Leu Ala 
        915                 920                 925


Ser Ile Asn Glu Glu Leu Phe Asn Ile Val Asp Leu Leu Thr Pro Phe 
    930                 935                 940


Gln Ser Ala Cys His Phe Leu Val Glu Lys Arg Leu Ala Arg Pro Val 
945                 950                 955                 960


Lys Leu Gln Lys Pro Leu Glu Ser Ser Val Gln Leu His Ser Tyr Phe 
                965                 970                 975


Tyr Ser Thr His Asp Met Lys Ile Gly Ser Glu Glu Leu Val Tyr Ile 
            980                 985                 990


Thr His Ile Asp Asp Pro Trp Thr Phe Tyr Cys Gln Leu Ala Arg Asn 
        995                 1000                1005


Ala Asn Ile Leu Glu Gln Leu Ser Cys Ser Ile Thr Gln Leu Ser Lys 
    1010                1015                1020


Val Leu Leu Asn Leu Lys Thr Ser Pro Leu Asn Pro Gly Thr Leu Cys 
1025                1030                1035                1040


Leu Ala Lys Tyr Thr Asp Gly Asn Trp Tyr Arg Gly Ile Val Ile Glu 
                1045                1050                1055


Lys Glu Pro Lys Lys Val Phe Phe Val Asp Phe Gly Asn Ile Tyr Val 
            1060                1065                1070


Val Thr Ser Asp Asp Leu Leu Pro Ile Pro Ser Asp Ala Tyr Asp Val 
        1075                1080                1085


Leu Leu Leu Pro Met Gln Ala Val Arg Cys Ser Leu Ser Asp Ile Pro 
    1090                1095                1100


Asp His Ile Pro Glu Glu Val Val Val Trp Phe Gln Glu Thr Ile Leu 
1105                1110                1115                1120


Asp Lys Ser Leu Lys Ala Leu Val Val Ala Lys Asp Pro Asp Gly Thr 
                1125                1130                1135


Leu Ile Ile Glu Leu Tyr Gly Asp Asn Ile Gln Ile Ser Ala Ser Ile 
            1140                1145                1150


Asn Lys Lys Leu Gly Leu Leu Ser Tyr Lys Asp Arg Ile Arg Lys Lys 
        1155                1160                1165


Glu Ser Glu Val Leu Cys Ser Thr Thr Glu Thr Leu Glu Glu Lys Asn 
    1170                1175                1180


Glu Asn Met Lys Leu Pro Cys Thr Glu Tyr Leu Ser Lys Ser Val Gly 
1185                1190                1195                1200


Tyr Lys Leu Pro Asn Lys Glu Ile Leu Glu Glu Ser Tyr Lys Pro Gln 
                1205                1210                1215


Ile Asn Ser Ser Tyr Lys Glu Leu Lys Leu Leu Gln Ser Leu Thr Lys 
            1220                1225                1230


Thr Asn Leu Val Thr Gln Tyr Gln Asp Ser Val Gly Asn Lys Asn Ser 
        1235                1240                1245


Gln Val Phe Pro Leu Thr Thr Glu Lys Lys Glu Glu Ile Ser Ala Glu 
    1250                1255                1260


Thr Pro Leu Lys Thr Ala Arg Val Glu Ala Thr Leu Ser Glu Arg Lys 
1265                1270                1275                1280


Ile Gly Asp Ser Cys Asp Lys Asp Leu Pro Leu Lys Phe Cys Glu Phe 
                1285                1290                1295


Pro Gln Lys Thr Ile Met Pro Gly Phe Lys Thr Thr Val Tyr Val Ser 
            1300                1305                1310


His Ile Asn Asp Leu Ser Asp Phe Tyr Val Gln Leu Ile Glu Asp Glu 
        1315                1320                1325


Ala Glu Ile Ser His Leu Ser Glu Arg Leu Asn Ser Val Lys Thr Arg 
    1330                1335                1340


Pro Glu Tyr Tyr Val Gly Pro Pro Leu Gln Arg Gly Asp Met Ile Cys 
1345                1350                1355                1360


Ala Val Phe Pro Glu Asp Asn Leu Trp Tyr Arg Ala Val Ile Lys Glu 
                1365                1370                1375


Gln Gln Pro Asn Asp Leu Leu Ser Val Gln Phe Ile Asp Tyr Gly Asn 
            1380                1385                1390


Val Ser Val Val His Thr Asn Lys Ile Gly Arg Leu Asp Leu Val Asn 
        1395                1400                1405


Ala Ile Leu Pro Gly Leu Cys Ile His Cys Ser Leu Gln Gly Phe Glu 
    1410                1415                1420


Val Pro Asp Asn Lys Asn Ser Lys Lys Met Met His Tyr Phe Ser Gln 
1425                1430                1435                1440


Arg Thr Ser Glu Ala Ala Ile Arg Cys Glu Phe Val Lys Phe Gln Asp 
                1445                1450                1455


Arg Trp Glu Val Ile Leu Ala Asp Glu His Gly Ile Ile Ala Asp Asp 
            1460                1465                1470


Met Ile Ser Arg Tyr Ala Leu Ser Glu Lys Ser Gln Val Glu Leu Ser 
        1475                1480                1485


Thr Gln Val Ile Lys Ser Ala Ser Ser Lys Ser Val Asn Lys Ser Asp 
    1490                1495                1500


Ile Asp Thr Ser Val Phe Leu Asn Trp Tyr Asn Pro Glu Lys Lys Met 
1505                1510                1515                1520


Ile Arg Ala Tyr Ala Thr Val Ile Asp Gly Pro Glu Tyr Phe Trp Cys 
                1525                1530                1535


Gln Phe Ala Asp Thr Glu Lys Leu Gln Cys Leu Glu Val Glu Val Gln 
            1540                1545                1550


Thr Ala Gly Glu Gln Val Ala Asp Arg Arg Asn Cys Ile Pro Cys Pro 
        1555                1560                1565


Tyr Ile Gly Asp Pro Cys Ile Val Arg Tyr Arg Glu Asp Gly His Tyr 
    1570                1575                1580


Tyr Arg Ala Leu Ile Thr Asn Ile Cys Glu Asp Tyr Leu Val Ser Val 
1585                1590                1595                1600


Arg Leu Val Asp Phe Gly Asn Ile Glu Asp Cys Val Asp Pro Lys Ala 
                1605                1610                1615


Leu Trp Ala Ile Pro Ser Glu Leu Leu Ser Val Pro Met Gln Ala Phe 
            1620                1625                1630


Pro Cys Cys Leu Ser Gly Phe Asn Ile Ser Glu Gly Leu Cys Ser Gln 
        1635                1640                1645


Glu Gly Asn Asp Tyr Phe Tyr Glu Ile Ile Thr Glu Asp Val Leu Glu 
    1650                1655                1660


Ile Thr Ile Leu Glu Ile Arg Arg Asp Val Cys Asp Ile Pro Leu Ala 
1665                1670                1675                1680


Ile Val Asp Leu Lys Ser Lys Gly Lys Ser Ile Asn Glu Lys Met Glu 
                1685                1690                1695


Lys Tyr Ser Lys Thr Gly Ile Lys Ser Ala Leu Pro Tyr Glu Asn Ile 
            1700                1705                1710


Asp Ser Glu Ile Lys Gln Thr Leu Gly Ser Tyr Asn Leu Asp Val Gly 
        1715                1720                1725


Leu Lys Lys Leu Ser Asn Lys Ala Val Gln Asn Lys Ile Tyr Met Glu 
    1730                1735                1740


Gln Gln Thr Asp Glu Leu Ala Glu Ile Thr Glu Lys Asp Val Asn Ile 
1745                1750                1755                1760


Ile Gly Thr Lys Pro Ser Asn Phe Arg Asp Pro Lys Thr Asp Asn Ile 
                1765                1770                1775


Cys Glu Gly Phe Glu Asn Pro Cys Lys Asp Lys Ile Asp Thr Glu Glu 
            1780                1785                1790


Leu Glu Gly Glu Leu Glu Cys His Leu Val Asp Lys Ala Glu Phe Asp 
        1795                1800                1805


Asp Lys Tyr Leu Ile Thr Gly Phe Asn Thr Leu Leu Pro His Ala Asn 
    1810                1815                1820


Glu Thr Lys Glu Ile Leu Glu Leu Asn Ser Leu Glu Val Pro Leu Ser 
1825                1830                1835                1840


Pro Asp Asp Glu Ser Lys Glu Phe Leu Glu Leu Glu Ser Ile Glu Leu 
                1845                1850                1855


Gln Asn Ser Leu Val Val Asp Glu Glu Lys Gly Glu Leu Ser Pro Val 
            1860                1865                1870


Pro Pro Asn Val Pro Leu Ser Gln Glu Cys Val Thr Lys Gly Ala Met 
        1875                1880                1885


Glu Leu Phe Thr Leu Gln Leu Pro Leu Ser Cys Glu Ala Glu Lys Gln 
    1890                1895                1900


Pro Glu Leu Glu Leu Pro Thr Ala Gln Leu Pro Leu Asp Asp Lys Met 
1905                1910                1915                1920


Asp Pro Leu Ser Leu Gly Val Ser Gln Lys Ala Gln Glu Ser Met Cys 
                1925                1930                1935


Thr Glu Asp Met Arg Lys Ser Ser Cys Val Glu Ser Phe Asp Asp Gln 
            1940                1945                1950


Arg Arg Met Ser Leu His Leu His Gly Ala Asp Cys Asp Pro Lys Thr 
        1955                1960                1965


Gln Asn Glu Met Asn Ile Cys Glu Glu Glu Phe Val Glu Tyr Lys Asn 
    1970                1975                1980


Arg Asp Ala Ile Ser Ala Leu Met Pro Leu Phe Ser Glu Glu Glu Ser 
1985                1990                1995                2000


Ser Asp Gly Ser Lys His Asn Asn Gly Leu Pro Asp His Ile Ser Ala 
                2005                2010                2015


Gln Leu Gln Asn Thr Tyr Thr Leu Lys Ala Phe Thr Val Gly Ser Lys 
            2020                2025                2030


Cys Val Val Trp Ser Ser Leu Arg Asn Thr Trp Ser Lys Cys Glu Ile 
        2035                2040                2045


Leu Glu Thr Ala Glu Glu Gly Thr Arg Val Leu Asn Leu Ser Asn Gly 
    2050                2055                2060


Met Glu Glu Ile Val Asn Pro Glu Asn Val Trp Asn Gly Ile Pro Lys 
2065                2070                2075                2080


Leu Asp Lys Ser Pro Pro Glu Lys Arg Gly Leu Glu Val Met Glu Ile 
                2085                2090                2095


<210>  3236
<211>  4085
<212>  DNA
<213>  Homo sapiens

<400>  3236
ttaattcaac cagttggcca gaatcccttt gtttgggatg taaaggcaat acaagctttc     60

aatgaattta tagataatgc atggcaaaaa aatctagaat taaaatgtac aatatttgct    120

ctggcttcaa ttaatgaaga actgtttaac attgtggatt tgctaacccc ctttcagagt    180

gcatgccatt tcttggtaga aaagagactt gcaagaccag taaaacttca gaagcctttg    240

gagtcctctg ttcagctaca ttcctacttc tattctacac atgatatgaa aattggaagt    300

gaagaattag tttatataac gcatattgat gacccttgga cattttattg ccagctggca    360

agaaatgcaa atattttaga acagttgtca tgtagtatta cacaattaag taaagttttg    420

ctgaatttaa aaacatctcc cttgaaccct ggaaccttgt gccttgccaa gtatactgat    480

ggaaactggt ataggggcat agtaatagag aaagagccaa agaaagtctt ctttgttgat    540

tttgggaata tttatgtagt aacaagtgat gatctgcttc caatacctag tgatgcatat    600

gatgtcttac ttttgcccat gcaagctgtc agatgttcat tatctgatat tcctgatcat    660

ataccagaag aagtggtggt gtggtttcag gagactattt tagataagtc attgaaggct    720

ttagttgtag caaaagatcc agatggaaca ctgattatag aactatatgg tgacaatatt    780

caaattagtg ctagtattaa taagaagttg gggctactta gttacaaaga tagaataaga    840

aaaaaagaaa gtgaagtcct ctgttctaca actgaaactc ttgaagaaaa aaatgagaat    900

atgaagttgc catgtacaga gtatttaagt aaatcagtag ggtacaagtt acctaataaa    960

gaaattttgg aagagtcata taaacctcag atcaactcat catacaagga actcaaactt   1020

ttacaaagtt taacaaaaac aaacttagtc actcaatatc aagactctgt gggaaataaa   1080

aatagtcaag tgtttccatt aacaacagaa aagaaagaag aaatttctgc tgagacaccc   1140

ttgaaaacag caagagtaga agctactctt tcagagagaa aaataggaga ttcatgtgac   1200

aaagatttgc ctctgaaatt ttgtgagttc ccacagaaga ctataatgcc tggatttaaa   1260

acaactgtat atgtttctca tataaatgac ctttcagact tttatgttca actaatagaa   1320

gatgaagctg aaattagtca tctttcagag agattaaaca gtgttaaaac aaggcccgaa   1380

tattatgtag gtccaccttt gcaaagagga gatatgatat gtgctgtttt cccagaagat   1440

aatttatggt atcgtgctgt gatcaaggag caacaaccca atgaccttct ctctgtgcag   1500

tttatagatt atggcaatgt ttctgtggtt catactaaca aaataggtag gcttgacctt   1560

gttaatgcaa tattgccggg gttgtgcatt cattgctcct tgcagggatt tgaggttcct   1620

gacaataaaa attctaagaa aatgatgcat tacttttccc aacggaccag cgaggctgca   1680

ataagatgtg aatttgttaa atttcaagac agatgggaag ttattcttgc tgatgaacat   1740

gggatcatag cagatgatat gattagcagg tatgctctca gtgaaaaatc tcaagtagaa   1800

ctttctaccc aagtaattaa aagtgccagt tcaaagtctg ttaacaaatc agacattgac   1860

acttcagtat ttcttaactg gtataatcca gaaaaaaaaa tgataagagc ttatgccact   1920

gtgatagatg gacctgagta cttttggtgt cagtttgctg atacggagaa acttcagtgt   1980

ttagaagtag aagtacagac tgctggagaa caggtagcag acaggagaaa ttgtatccca   2040

tgtccttata ttggagatcc ttgtatagta agatacagag aagatggaca ttattatagg   2100

gcacttatca ctaatatttg tgaagattat cttgtatctg tcaggcttgt ggactttgga   2160

aacattgaag actgtgtgga cccaaaagca ctctgggcca ttccttctga acttctgtcg   2220

gttcccatgc aagcctttcc atgttgcctc tcagggttta acatttcaga aggattatgt   2280

tctcaagagg gaaatgacta tttctatgaa ataataacag aagatgtgtt ggaaataaca   2340

atactagaaa tcagaaggga tgtttgtgat atccctttag caattgttga cttgaaaagc   2400

aaaggtaaaa gtattaatga gaaaatggag aaatattcta agactggtat taaaagtgct   2460

cttccctatg aaaatattga ctcagagata aagcagactc ttgggtccta caatcttgat   2520

gtaggactta agaaattaag taataaagct gtacaaaata aaatatatat ggaacaacag   2580

acagatgagc ttgctgaaat aactgaaaaa gatgtaaaca ttattggaac caaaccaagt   2640

aacttccgtg accctaaaac tgataacatt tgtgaagggt ttgaaaaccc ctgcaaagat   2700

aaaattgata ctgaggaact ggaaggtgaa ttagagtgcc atctggttga caaagcagag   2760

tttgatgata aatacctgat tacaggattt aacacattac taccacatgc taatgaaaca   2820

aaggagatac tagaactgaa ttcacttgag gtgccgcttt ctcctgatga tgaatcaaaa   2880

gaattcttag aactggaatc tattgagtta cagaattctc tggtggtgga tgaagaaaaa   2940

ggggagctaa gcccggtgcc accgaatgtg ccactctccc aagagtgtgt cacaaaaggc   3000

gccatggagc tatttacact gcagcttcct ctcagctgtg aagctgagaa acagccagaa   3060

ctagaactac ctacagccca gctgccttta gatgacaaga tggatccttt gtctttagga   3120

gttagtcaga aagcacagga atccatgtgt actgaggaca tgagaaagtc aagttgtgta   3180

gaatcttttg atgaccagcg caggatgtca ttgcatctac atggagcaga ttgtgatcct   3240

aaaacacaga atgaaatgaa tatatgtgaa gaagaatttg tagagtataa aaacagggat   3300

gccatttcgg cattgatgcc tttgttctct gaggaagaaa gcagtgatgg aagcaagcac   3360

aataatggtt taccagatca tatctcagct caactacaga acacctacac tctgaaagcc   3420

tttactgttg gatctaaatg tgttgtgtgg tcaagtctaa gaaacacatg gtctaaatgt   3480

gagattttag aaacagctga agaaggaaca aggaaaaggg gtttggaggt gatggagatt   3540

taaccgtgga tctatagctg tggccaatca gtcagaagct gcccttgaac aagtggcatc   3600

ttacgcagac caacagagta tttgagaaaa ttgaaaacat gtaaccacaa gaagttgtca   3660

ttttcaaaaa cttctatata ggtggaaaac aaattaggtc tcaggttgat ggtggggtgt   3720

gtttatagtg atcctgttat atatacagat ctgggatctt tcgtctttat tgtcttacgt   3780

ttctaattag ttgggaggat ttattttgct aaacagttta ctaacacatt acatttcaaa   3840

aactattttg gtacctttca aatacagtgt ttaaattaaa atagaaaaat aagggctcat   3900

gacaagtaca ttatttgatt ctacttagga tagcttttta gcaggatctc cttcagaatt   3960

tttgtcttga ctttgaatct ttgcctgttt gtctaaacat ttgactaaca ttctgtttga   4020

atttggaagt attctaatac aagatttgaa taaagtttat ccttaaataa agtttatcct   4080

taata                                                               4085


<210>  3237
<211>  1085
<212>  PRT
<213>  Homo sapiens

<400>  3237

Met Lys Ile Gly Ser Glu Glu Leu Val Tyr Ile Thr His Ile Asp Asp 
1               5                   10                  15


Pro Trp Thr Phe Tyr Cys Gln Leu Ala Arg Asn Ala Asn Ile Leu Glu 
            20                  25                  30


Gln Leu Ser Cys Ser Ile Thr Gln Leu Ser Lys Val Leu Leu Asn Leu 
        35                  40                  45


Lys Thr Ser Pro Leu Asn Pro Gly Thr Leu Cys Leu Ala Lys Tyr Thr 
    50                  55                  60


Asp Gly Asn Trp Tyr Arg Gly Ile Val Ile Glu Lys Glu Pro Lys Lys 
65                  70                  75                  80


Val Phe Phe Val Asp Phe Gly Asn Ile Tyr Val Val Thr Ser Asp Asp 
                85                  90                  95


Leu Leu Pro Ile Pro Ser Asp Ala Tyr Asp Val Leu Leu Leu Pro Met 
            100                 105                 110


Gln Ala Val Arg Cys Ser Leu Ser Asp Ile Pro Asp His Ile Pro Glu 
        115                 120                 125


Glu Val Val Val Trp Phe Gln Glu Thr Ile Leu Asp Lys Ser Leu Lys 
    130                 135                 140


Ala Leu Val Val Ala Lys Asp Pro Asp Gly Thr Leu Ile Ile Glu Leu 
145                 150                 155                 160


Tyr Gly Asp Asn Ile Gln Ile Ser Ala Ser Ile Asn Lys Lys Leu Gly 
                165                 170                 175


Leu Leu Ser Tyr Lys Asp Arg Ile Arg Lys Lys Glu Ser Glu Val Leu 
            180                 185                 190


Cys Ser Thr Thr Glu Thr Leu Glu Glu Lys Asn Glu Asn Met Lys Leu 
        195                 200                 205


Pro Cys Thr Glu Tyr Leu Ser Lys Ser Val Gly Tyr Lys Leu Pro Asn 
    210                 215                 220


Lys Glu Ile Leu Glu Glu Ser Tyr Lys Pro Gln Ile Asn Ser Ser Tyr 
225                 230                 235                 240


Lys Glu Leu Lys Leu Leu Gln Ser Leu Thr Lys Thr Asn Leu Val Thr 
                245                 250                 255


Gln Tyr Gln Asp Ser Val Gly Asn Lys Asn Ser Gln Val Phe Pro Leu 
            260                 265                 270


Thr Thr Glu Lys Lys Glu Glu Ile Ser Ala Glu Thr Pro Leu Lys Thr 
        275                 280                 285


Ala Arg Val Glu Ala Thr Leu Ser Glu Arg Lys Ile Gly Asp Ser Cys 
    290                 295                 300


Asp Lys Asp Leu Pro Leu Lys Phe Cys Glu Phe Pro Gln Lys Thr Ile 
305                 310                 315                 320


Met Pro Gly Phe Lys Thr Thr Val Tyr Val Ser His Ile Asn Asp Leu 
                325                 330                 335


Ser Asp Phe Tyr Val Gln Leu Ile Glu Asp Glu Ala Glu Ile Ser His 
            340                 345                 350


Leu Ser Glu Arg Leu Asn Ser Val Lys Thr Arg Pro Glu Tyr Tyr Val 
        355                 360                 365


Gly Pro Pro Leu Gln Arg Gly Asp Met Ile Cys Ala Val Phe Pro Glu 
    370                 375                 380


Asp Asn Leu Trp Tyr Arg Ala Val Ile Lys Glu Gln Gln Pro Asn Asp 
385                 390                 395                 400


Leu Leu Ser Val Gln Phe Ile Asp Tyr Gly Asn Val Ser Val Val His 
                405                 410                 415


Thr Asn Lys Ile Gly Arg Leu Asp Leu Val Asn Ala Ile Leu Pro Gly 
            420                 425                 430


Leu Cys Ile His Cys Ser Leu Gln Gly Phe Glu Val Pro Asp Asn Lys 
        435                 440                 445


Asn Ser Lys Lys Met Met His Tyr Phe Ser Gln Arg Thr Ser Glu Ala 
    450                 455                 460


Ala Ile Arg Cys Glu Phe Val Lys Phe Gln Asp Arg Trp Glu Val Ile 
465                 470                 475                 480


Leu Ala Asp Glu His Gly Ile Ile Ala Asp Asp Met Ile Ser Arg Tyr 
                485                 490                 495


Ala Leu Ser Glu Lys Ser Gln Val Glu Leu Ser Thr Gln Val Ile Lys 
            500                 505                 510


Ser Ala Ser Ser Lys Ser Val Asn Lys Ser Asp Ile Asp Thr Ser Val 
        515                 520                 525


Phe Leu Asn Trp Tyr Asn Pro Glu Lys Lys Met Ile Arg Ala Tyr Ala 
    530                 535                 540


Thr Val Ile Asp Gly Pro Glu Tyr Phe Trp Cys Gln Phe Ala Asp Thr 
545                 550                 555                 560


Glu Lys Leu Gln Cys Leu Glu Val Glu Val Gln Thr Ala Gly Glu Gln 
                565                 570                 575


Val Ala Asp Arg Arg Asn Cys Ile Pro Cys Pro Tyr Ile Gly Asp Pro 
            580                 585                 590


Cys Ile Val Arg Tyr Arg Glu Asp Gly His Tyr Tyr Arg Ala Leu Ile 
        595                 600                 605


Thr Asn Ile Cys Glu Asp Tyr Leu Val Ser Val Arg Leu Val Asp Phe 
    610                 615                 620


Gly Asn Ile Glu Asp Cys Val Asp Pro Lys Ala Leu Trp Ala Ile Pro 
625                 630                 635                 640


Ser Glu Leu Leu Ser Val Pro Met Gln Ala Phe Pro Cys Cys Leu Ser 
                645                 650                 655


Gly Phe Asn Ile Ser Glu Gly Leu Cys Ser Gln Glu Gly Asn Asp Tyr 
            660                 665                 670


Phe Tyr Glu Ile Ile Thr Glu Asp Val Leu Glu Ile Thr Ile Leu Glu 
        675                 680                 685


Ile Arg Arg Asp Val Cys Asp Ile Pro Leu Ala Ile Val Asp Leu Lys 
    690                 695                 700


Ser Lys Gly Lys Ser Ile Asn Glu Lys Met Glu Lys Tyr Ser Lys Thr 
705                 710                 715                 720


Gly Ile Lys Ser Ala Leu Pro Tyr Glu Asn Ile Asp Ser Glu Ile Lys 
                725                 730                 735


Gln Thr Leu Gly Ser Tyr Asn Leu Asp Val Gly Leu Lys Lys Leu Ser 
            740                 745                 750


Asn Lys Ala Val Gln Asn Lys Ile Tyr Met Glu Gln Gln Thr Asp Glu 
        755                 760                 765


Leu Ala Glu Ile Thr Glu Lys Asp Val Asn Ile Ile Gly Thr Lys Pro 
    770                 775                 780


Ser Asn Phe Arg Asp Pro Lys Thr Asp Asn Ile Cys Glu Gly Phe Glu 
785                 790                 795                 800


Asn Pro Cys Lys Asp Lys Ile Asp Thr Glu Glu Leu Glu Gly Glu Leu 
                805                 810                 815


Glu Cys His Leu Val Asp Lys Ala Glu Phe Asp Asp Lys Tyr Leu Ile 
            820                 825                 830


Thr Gly Phe Asn Thr Leu Leu Pro His Ala Asn Glu Thr Lys Glu Ile 
        835                 840                 845


Leu Glu Leu Asn Ser Leu Glu Val Pro Leu Ser Pro Asp Asp Glu Ser 
    850                 855                 860


Lys Glu Phe Leu Glu Leu Glu Ser Ile Glu Leu Gln Asn Ser Leu Val 
865                 870                 875                 880


Val Asp Glu Glu Lys Gly Glu Leu Ser Pro Val Pro Pro Asn Val Pro 
                885                 890                 895


Leu Ser Gln Glu Cys Val Thr Lys Gly Ala Met Glu Leu Phe Thr Leu 
            900                 905                 910


Gln Leu Pro Leu Ser Cys Glu Ala Glu Lys Gln Pro Glu Leu Glu Leu 
        915                 920                 925


Pro Thr Ala Gln Leu Pro Leu Asp Asp Lys Met Asp Pro Leu Ser Leu 
    930                 935                 940


Gly Val Ser Gln Lys Ala Gln Glu Ser Met Cys Thr Glu Asp Met Arg 
945                 950                 955                 960


Lys Ser Ser Cys Val Glu Ser Phe Asp Asp Gln Arg Arg Met Ser Leu 
                965                 970                 975


His Leu His Gly Ala Asp Cys Asp Pro Lys Thr Gln Asn Glu Met Asn 
            980                 985                 990


Ile Cys Glu Glu Glu Phe Val Glu Tyr Lys Asn Arg Asp Ala Ile Ser 
        995                 1000                1005


Ala Leu Met Pro Leu Phe Ser Glu Glu Glu Ser Ser Asp Gly Ser Lys 
    1010                1015                1020


His Asn Asn Gly Leu Pro Asp His Ile Ser Ala Gln Leu Gln Asn Thr 
1025                1030                1035                1040


Tyr Thr Leu Lys Ala Phe Thr Val Gly Ser Lys Cys Val Val Trp Ser 
                1045                1050                1055


Ser Leu Arg Asn Thr Trp Ser Lys Cys Glu Ile Leu Glu Thr Ala Glu 
            1060                1065                1070


Glu Gly Thr Arg Lys Arg Gly Leu Glu Val Met Glu Ile 
        1075                1080                1085


<210>  3238
<211>  1952
<212>  DNA
<213>  Homo sapiens

<400>  3238
gagggtcggg gccacaaggc cgcgctaggc ggacccagga cacagcccgc gcgcagccca     60

cccgcccgcc gcctgccaga gctgctcggc ccgcagccag ggggacagcg gctggtcgga    120

ggctcgcagt gctgtcggcg agaagcagtc gggtttggag cgcttgggtc gcgttggtgc    180

gcggtggaac gcgcccaggg accccagttc ccgcgagcag ctccgcgccg cgcctgagag    240

actaagctga aactgctgct cagctcccaa gatggtgcca cccaaattgc atgtgctttt    300

ctgcctctgc ggctgcctgg ctgtggttta tccttttgac tggcaataca taaatcctgt    360

tgcccatatg aaatcatcag catgggtcaa caaaatacaa gtactgatgg ctgctgcaag    420

ctttggccaa actaaaatcc cccggggaaa tgggccttat tccgttggtt gtacagactt    480

aatgtttgat cacactaata agggcacctt cttgcgttta tattatccat cccaagataa    540

tgatcgcctt gacacccttt ggatcccaaa taaagaatat ttttggggtc ttagcaaatt    600

tcttggaaca cactggctta tgggcaacat tttgaggtta ctctttggtt caatgacaac    660

tcctgcaaac tggaattccc ctctgaggcc tggtgaaaaa tatccacttg ttgttttttc    720

tcatggtctt ggggcattca ggacacttta ttctgctatt ggcattgacc tggcatctca    780

tgggtttata gttgctgctg tagaacacag agatagatct gcatctgcaa cttactattt    840

caaggaccaa tctgctgcag aaatagggga caagtcttgg ctctacctta gaaccctgaa    900

acaagaggag gagacacata tacgaaatga gcaggtacgg caaagagcaa aagaatgttc    960

ccaagctctc agtctgattc ttgacattga tcatggaaag ccagtgaaga atgcattaga   1020

tttaaagttt gatatggaac aactgaagga ctctattgat agggaaaaaa tagcagtaat   1080

tggacattct tttggtggag caacggttat tcagactctt agtgaagatc agagattcag   1140

atgtggtatt gccctggatg catggatgtt tccactgggt gatgaagtat attccagaat   1200

tcctcagccc ctctttttta tcaactctga atatttccaa tatcctgcta atatcataaa   1260

aatgaaaaaa tgctactcac ctgataaaga aagaaagatg attacaatca ggggttcagt   1320

ccaccagaat tttgctgact tcacttttgc aactggcaaa ataattggac acatgctcaa   1380

attaaaggga gacatagatt caaatgtagc tattgatctt agcaacaaag cttcattagc   1440

attcttacaa aagcatttag gacttcataa agattttgat cagtgggact gcttgattga   1500

aggagatgat gagaatctta ttccagggac caacattaac acaaccaatc aacacatcat   1560

gttacagaac tcttcaggaa tagagaaata caattaggat taaaataggt tttttaaaag   1620

tcttgtttca aaactgtcta aaattatgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgag   1680

agagagagag agagagagag agagagagag agagaatttt aatgtatttt cccaaaggac   1740

tcatatttta aaatgtaggc tatactgtaa tcgtgattga agcttggact aagaattttt   1800

tccctttaga tgtaaagaaa gaatacagta tacaatattc atatcagcct aaattttaat   1860

tttaaagatg attccttttc agtgtcgaag ttaaaaactg tttttacatt actttgacag   1920

acaagtagat taaaacaggc aaaatcccag tg                                 1952


<210>  3239
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  3239

Met Val Pro Pro Lys Leu His Val Leu Phe Cys Leu Cys Gly Cys Leu 
1               5                   10                  15


Ala Val Val Tyr Pro Phe Asp Trp Gln Tyr Ile Asn Pro Val Ala His 
            20                  25                  30


Met Lys Ser Ser Ala Trp Val Asn Lys Ile Gln Val Leu Met Ala Ala 
        35                  40                  45


Ala Ser Phe Gly Gln Thr Lys Ile Pro Arg Gly Asn Gly Pro Tyr Ser 
    50                  55                  60


Val Gly Cys Thr Asp Leu Met Phe Asp His Thr Asn Lys Gly Thr Phe 
65                  70                  75                  80


Leu Arg Leu Tyr Tyr Pro Ser Gln Asp Asn Asp Arg Leu Asp Thr Leu 
                85                  90                  95


Trp Ile Pro Asn Lys Glu Tyr Phe Trp Gly Leu Ser Lys Phe Leu Gly 
            100                 105                 110


Thr His Trp Leu Met Gly Asn Ile Leu Arg Leu Leu Phe Gly Ser Met 
        115                 120                 125


Thr Thr Pro Ala Asn Trp Asn Ser Pro Leu Arg Pro Gly Glu Lys Tyr 
    130                 135                 140


Pro Leu Val Val Phe Ser His Gly Leu Gly Ala Phe Arg Thr Leu Tyr 
145                 150                 155                 160


Ser Ala Ile Gly Ile Asp Leu Ala Ser His Gly Phe Ile Val Ala Ala 
                165                 170                 175


Val Glu His Arg Asp Arg Ser Ala Ser Ala Thr Tyr Tyr Phe Lys Asp 
            180                 185                 190


Gln Ser Ala Ala Glu Ile Gly Asp Lys Ser Trp Leu Tyr Leu Arg Thr 
        195                 200                 205


Leu Lys Gln Glu Glu Glu Thr His Ile Arg Asn Glu Gln Val Arg Gln 
    210                 215                 220


Arg Ala Lys Glu Cys Ser Gln Ala Leu Ser Leu Ile Leu Asp Ile Asp 
225                 230                 235                 240


His Gly Lys Pro Val Lys Asn Ala Leu Asp Leu Lys Phe Asp Met Glu 
                245                 250                 255


Gln Leu Lys Asp Ser Ile Asp Arg Glu Lys Ile Ala Val Ile Gly His 
            260                 265                 270


Ser Phe Gly Gly Ala Thr Val Ile Gln Thr Leu Ser Glu Asp Gln Arg 
        275                 280                 285


Phe Arg Cys Gly Ile Ala Leu Asp Ala Trp Met Phe Pro Leu Gly Asp 
    290                 295                 300


Glu Val Tyr Ser Arg Ile Pro Gln Pro Leu Phe Phe Ile Asn Ser Glu 
305                 310                 315                 320


Tyr Phe Gln Tyr Pro Ala Asn Ile Ile Lys Met Lys Lys Cys Tyr Ser 
                325                 330                 335


Pro Asp Lys Glu Arg Lys Met Ile Thr Ile Arg Gly Ser Val His Gln 
            340                 345                 350


Asn Phe Ala Asp Phe Thr Phe Ala Thr Gly Lys Ile Ile Gly His Met 
        355                 360                 365


Leu Lys Leu Lys Gly Asp Ile Asp Ser Asn Val Ala Ile Asp Leu Ser 
    370                 375                 380


Asn Lys Ala Ser Leu Ala Phe Leu Gln Lys His Leu Gly Leu His Lys 
385                 390                 395                 400


Asp Phe Asp Gln Trp Asp Cys Leu Ile Glu Gly Asp Asp Glu Asn Leu 
                405                 410                 415


Ile Pro Gly Thr Asn Ile Asn Thr Thr Asn Gln His Ile Met Leu Gln 
            420                 425                 430


Asn Ser Ser Gly Ile Glu Lys Tyr Asn 
        435                 440


<210>  3240
<211>  1840
<212>  DNA
<213>  Homo sapiens

<400>  3240
gagggtcggg gccacaaggc cgcgctaggc ggacccagga cacagcccgc gcgcagccca     60

cccgcccgcc gcctgccaga gctgctcggc ccgcagccag ggggacagcg gctggtcgga    120

ggctcgcagt gctgtcggcg agaagcagtc gggtttggag cgcttgggtc gcgttggtgc    180

gcggtggaac gcgcccaggg accccagttc ccgcgagcag ctccgcgccg cgcctgagag    240

actaagctga aactgctgct cagctcccaa gatggtgcca cccaaattgc atgtgctttt    300

ctgcctctgc ggctgcctgg ctgtggttta tccttttgac tggcaataca taaatcctgt    360

tgcccatatg aaatcatcag catgggtcaa caaaatacaa gtactgatgg ctgctgcaag    420

ctttggccaa actaaaatcc cccggggaaa tgggccttat tccgttggtt gtacagactt    480

aatgtttgat cacactaata agggcacctt cttgcgttta tattatccat cccaagataa    540

tgatcgcctt gacacccttt ggatcccaaa taaagaatat ttttggggtc ttagcaaatt    600

tcttggaaca cactggctta tgggcaacat tttgaggtta ctctttggtt caatgacaac    660

tcctgcaaac tggaattccc ctctgaggcc tggtgaaaaa tatccacttg ttgttttttc    720

tcatggtctt ggggcattca ggacacttta ttctgctatt ggcattgacc tggcatctca    780

tgggtttata gttgctgctg tagaacacag agatagatct gcatctgcaa cttactattt    840

caaggaccaa tctgctgcag aaatagggga caagtcttgg ctctacctta gaaccctgaa    900

acaagaggag gagacacata tacgaaatga gcaggtacgg caaagagcaa aagaatgttc    960

ccaagctctc agtctgattc ttgacattga tcatggaaag ccagtgaaga atgcattaga   1020

tttaaagttt gatatggaac aactgaagga ctctattgat agggaaaaaa tagcagtaat   1080

tggacattct tttggtggag caacggttat tcagactctt agtgaagatc agagattcag   1140

atgtggtatt gccctggatg catggatgtt tccactgggt gatgaagtat attccagaat   1200

tcctcagccc ctctttttta tcaactctga atatttccaa tatcctgcta atatcataaa   1260

aatgaaaaaa tgctactcac ctgataaaga aagaaagatg attacaatca ggggttcagt   1320

ccaccagaat tttgctgact tcacttttgc aactggcaaa ataattggac acatgctcaa   1380

attaaaggga gacatagatt caaatgtagc tattgatctt agcaacaaag cttcattagc   1440

attcttacaa aagcatttag gacttcataa agattttgat cagtgggact gcttgattga   1500

aggagatgat gagaatctta ttccagggac caacattaac acaaccaatc aacacatcat   1560

gttacagaac tcttcaggaa tagagaaata caattaggat taaaataggt tttttaaaag   1620

tcttgtttca aaactgtcta aaattatgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgag   1680

agagagagag agagagagag agagagagag agagaatttt aatgtatttt cccaaaggac   1740

tcatatttta aaatgtaggc tatactgtaa tcgtgattga agcttggact aagaattttt   1800

tccctttaga tgtaaagaaa gaatacagta tacaatattc                         1840


<210>  3241
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  3241

Met Val Pro Pro Lys Leu His Val Leu Phe Cys Leu Cys Gly Cys Leu 
1               5                   10                  15


Ala Val Val Tyr Pro Phe Asp Trp Gln Tyr Ile Asn Pro Val Ala His 
            20                  25                  30


Met Lys Ser Ser Ala Trp Val Asn Lys Ile Gln Val Leu Met Ala Ala 
        35                  40                  45


Ala Ser Phe Gly Gln Thr Lys Ile Pro Arg Gly Asn Gly Pro Tyr Ser 
    50                  55                  60


Val Gly Cys Thr Asp Leu Met Phe Asp His Thr Asn Lys Gly Thr Phe 
65                  70                  75                  80


Leu Arg Leu Tyr Tyr Pro Ser Gln Asp Asn Asp Arg Leu Asp Thr Leu 
                85                  90                  95


Trp Ile Pro Asn Lys Glu Tyr Phe Trp Gly Leu Ser Lys Phe Leu Gly 
            100                 105                 110


Thr His Trp Leu Met Gly Asn Ile Leu Arg Leu Leu Phe Gly Ser Met 
        115                 120                 125


Thr Thr Pro Ala Asn Trp Asn Ser Pro Leu Arg Pro Gly Glu Lys Tyr 
    130                 135                 140


Pro Leu Val Val Phe Ser His Gly Leu Gly Ala Phe Arg Thr Leu Tyr 
145                 150                 155                 160


Ser Ala Ile Gly Ile Asp Leu Ala Ser His Gly Phe Ile Val Ala Ala 
                165                 170                 175


Val Glu His Arg Asp Arg Ser Ala Ser Ala Thr Tyr Tyr Phe Lys Asp 
            180                 185                 190


Gln Ser Ala Ala Glu Ile Gly Asp Lys Ser Trp Leu Tyr Leu Arg Thr 
        195                 200                 205


Leu Lys Gln Glu Glu Glu Thr His Ile Arg Asn Glu Gln Val Arg Gln 
    210                 215                 220


Arg Ala Lys Glu Cys Ser Gln Ala Leu Ser Leu Ile Leu Asp Ile Asp 
225                 230                 235                 240


His Gly Lys Pro Val Lys Asn Ala Leu Asp Leu Lys Phe Asp Met Glu 
                245                 250                 255


Gln Leu Lys Asp Ser Ile Asp Arg Glu Lys Ile Ala Val Ile Gly His 
            260                 265                 270


Ser Phe Gly Gly Ala Thr Val Ile Gln Thr Leu Ser Glu Asp Gln Arg 
        275                 280                 285


Phe Arg Cys Gly Ile Ala Leu Asp Ala Trp Met Phe Pro Leu Gly Asp 
    290                 295                 300


Glu Val Tyr Ser Arg Ile Pro Gln Pro Leu Phe Phe Ile Asn Ser Glu 
305                 310                 315                 320


Tyr Phe Gln Tyr Pro Ala Asn Ile Ile Lys Met Lys Lys Cys Tyr Ser 
                325                 330                 335


Pro Asp Lys Glu Arg Lys Met Ile Thr Ile Arg Gly Ser Val His Gln 
            340                 345                 350


Asn Phe Ala Asp Phe Thr Phe Ala Thr Gly Lys Ile Ile Gly His Met 
        355                 360                 365


Leu Lys Leu Lys Gly Asp Ile Asp Ser Asn Val Ala Ile Asp Leu Ser 
    370                 375                 380


Asn Lys Ala Ser Leu Ala Phe Leu Gln Lys His Leu Gly Leu His Lys 
385                 390                 395                 400


Asp Phe Asp Gln Trp Asp Cys Leu Ile Glu Gly Asp Asp Glu Asn Leu 
                405                 410                 415


Ile Pro Gly Thr Asn Ile Asn Thr Thr Asn Gln His Ile Met Leu Gln 
            420                 425                 430


Asn Ser Ser Gly Ile Glu Lys Tyr Asn 
        435                 440


<210>  3242
<211>  1615
<212>  DNA
<213>  Homo sapiens

<400>  3242
gagggtcggg gccacaaggc cgcgctaggc ggacccagga cacagcccgc gcgcagccca     60

cccgcccgcc gcctgccaga gctgctcggc ccgcagccag ggggacagcg gctggtcgga    120

ggctcgcagt gctgtcggcg agaagcagtc gggtttggag cgcttgggtc gcgttggtgc    180

gcggtggaac gcgcccaggg accccagttc ccgcgagcag ctccgcgccg cgcctgagag    240

actaagctga aactgctgct cagctcccaa gatggtgcca cccaaattgc atgtgctttt    300

ctgcctctgc ggctgcctgg ctgtggttta tccttttgac tggcaataca taaatcctgt    360

tgcccatatg aaatcatcag catgggtcaa caaaatacaa gtactgatgg ctgctgcaag    420

ctttggccaa actaaaatcc cccggggaaa tgggccttat tccgttggtt gtacagactt    480

aatgtttgat cacactaata agggcacctt cttgcgttta tattatccat cccaagataa    540

tgatcgcctt gacacccttt ggatcccaaa taaagaatat ttttggggtc ttagcaaatt    600

tcttggaaca cactggctta tgggcaacat tttgaggtta ctctttggtt caatgacaac    660

tcctgcaaac tggaattccc ctctgaggcc tggtgaaaaa tatccacttg ttgttttttc    720

tcatggtctt ggggcattca ggacacttta ttctgctatt ggcattgacc tggcatctca    780

tgggtttata gttgctgctg tagaacacag agatagatct gcatctgcaa cttactattt    840

caaggaccaa tctgctgcag aaatagggga caagtcttgg ctctacctta gaaccctgaa    900

acaagaggag gagacacata tacgaaatga gcaggtacgg caaagagcaa aagaatgttc    960

ccaagctctc agtctgattc ttgacattga tcatggaaag ccagtgaaga atgcattaga   1020

tttaaagttt gatatggaac aactgaagga ctctattgat agggaaaaaa tagcagtaat   1080

tggacattct tttggtggag caacggttat tcagactctt agtgaagatc agagattcag   1140

atgtggtatt gccctggatg catggatgtt tccactgggt gatgaagtat attccagaat   1200

tcctcagccc ctctttttta tcaactctga atatttccaa tatcctgcta atatcataaa   1260

aatgaaaaaa tgctactcac ctgataaaga aagaaagatg attacaatca ggggttcagt   1320

ccaccagaat tttgctgact tcacttttgc aactggcaaa ataattggac acatgctcaa   1380

attaaaggga gacatagatt caaatgtagc tattgatctt agcaacaaag cttcattagc   1440

attcttacaa aagcatttag gacttcataa agattttgat cagtgggact gcttgattga   1500

aggagatgat gagaatctta ttccagggac caacattaac acaaccaatc aacacatcat   1560

gttacagaac tcttcaggaa tagagaaata caattaggat taaaataggt ttttt        1615


<210>  3243
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  3243

Met Val Pro Pro Lys Leu His Val Leu Phe Cys Leu Cys Gly Cys Leu 
1               5                   10                  15


Ala Val Val Tyr Pro Phe Asp Trp Gln Tyr Ile Asn Pro Val Ala His 
            20                  25                  30


Met Lys Ser Ser Ala Trp Val Asn Lys Ile Gln Val Leu Met Ala Ala 
        35                  40                  45


Ala Ser Phe Gly Gln Thr Lys Ile Pro Arg Gly Asn Gly Pro Tyr Ser 
    50                  55                  60


Val Gly Cys Thr Asp Leu Met Phe Asp His Thr Asn Lys Gly Thr Phe 
65                  70                  75                  80


Leu Arg Leu Tyr Tyr Pro Ser Gln Asp Asn Asp Arg Leu Asp Thr Leu 
                85                  90                  95


Trp Ile Pro Asn Lys Glu Tyr Phe Trp Gly Leu Ser Lys Phe Leu Gly 
            100                 105                 110


Thr His Trp Leu Met Gly Asn Ile Leu Arg Leu Leu Phe Gly Ser Met 
        115                 120                 125


Thr Thr Pro Ala Asn Trp Asn Ser Pro Leu Arg Pro Gly Glu Lys Tyr 
    130                 135                 140


Pro Leu Val Val Phe Ser His Gly Leu Gly Ala Phe Arg Thr Leu Tyr 
145                 150                 155                 160


Ser Ala Ile Gly Ile Asp Leu Ala Ser His Gly Phe Ile Val Ala Ala 
                165                 170                 175


Val Glu His Arg Asp Arg Ser Ala Ser Ala Thr Tyr Tyr Phe Lys Asp 
            180                 185                 190


Gln Ser Ala Ala Glu Ile Gly Asp Lys Ser Trp Leu Tyr Leu Arg Thr 
        195                 200                 205


Leu Lys Gln Glu Glu Glu Thr His Ile Arg Asn Glu Gln Val Arg Gln 
    210                 215                 220


Arg Ala Lys Glu Cys Ser Gln Ala Leu Ser Leu Ile Leu Asp Ile Asp 
225                 230                 235                 240


His Gly Lys Pro Val Lys Asn Ala Leu Asp Leu Lys Phe Asp Met Glu 
                245                 250                 255


Gln Leu Lys Asp Ser Ile Asp Arg Glu Lys Ile Ala Val Ile Gly His 
            260                 265                 270


Ser Phe Gly Gly Ala Thr Val Ile Gln Thr Leu Ser Glu Asp Gln Arg 
        275                 280                 285


Phe Arg Cys Gly Ile Ala Leu Asp Ala Trp Met Phe Pro Leu Gly Asp 
    290                 295                 300


Glu Val Tyr Ser Arg Ile Pro Gln Pro Leu Phe Phe Ile Asn Ser Glu 
305                 310                 315                 320


Tyr Phe Gln Tyr Pro Ala Asn Ile Ile Lys Met Lys Lys Cys Tyr Ser 
                325                 330                 335


Pro Asp Lys Glu Arg Lys Met Ile Thr Ile Arg Gly Ser Val His Gln 
            340                 345                 350


Asn Phe Ala Asp Phe Thr Phe Ala Thr Gly Lys Ile Ile Gly His Met 
        355                 360                 365


Leu Lys Leu Lys Gly Asp Ile Asp Ser Asn Val Ala Ile Asp Leu Ser 
    370                 375                 380


Asn Lys Ala Ser Leu Ala Phe Leu Gln Lys His Leu Gly Leu His Lys 
385                 390                 395                 400


Asp Phe Asp Gln Trp Asp Cys Leu Ile Glu Gly Asp Asp Glu Asn Leu 
                405                 410                 415


Ile Pro Gly Thr Asn Ile Asn Thr Thr Asn Gln His Ile Met Leu Gln 
            420                 425                 430


Asn Ser Ser Gly Ile Glu Lys Tyr Asn 
        435                 440


<210>  3244
<211>  1522
<212>  DNA
<213>  Homo sapiens

<400>  3244
ggaaaaccgg cctgactggg gggtgaattc agcagggagt aaatctgatc ggcatcaggt     60

ctgcggaaag gagctggtga gcacgacacc acccaggcat tgcctggctc tctccgcggc    120

gggctaagtt aaccgcgggt ccaggagact aagctgaaac tgctgctcag ctcccaagat    180

ggtgccaccc aaattgcatg tgcttttctg cctctgcggc tgcctggctg tggtttatcc    240

ttttgactgg caatacataa atcctgttgc ccatatgaaa tcatcagcat gggtcaacaa    300

aatacaagta ctgatggctg ctgcaagctt tggccaaact aaaatccccc ggggaaatgg    360

gccttattcc gttggttgta cagacttaat gtttgatcac actaataagg gcaccttctt    420

gcgtttatat tatccatccc aagataatga tcgccttgac accctttgga tcccaaataa    480

agaatatttt tggggtctta gcaaatttct tggaacacac tggcttatgg gcaacatttt    540

gaggttactc tttggttcaa tgacaactcc tgcaaactgg aattcccctc tgaggcctgg    600

tgaaaaatat ccacttgttg ttttttctca tggtcttggg gcattcagga cactttattc    660

tgctattggc attgacctgg catctcatgg gtttatagtt gctgctgtag aacacagaga    720

tagatctgca tctgcaactt actatttcaa ggaccaatct gctgcagaaa taggggacaa    780

gtcttggctc taccttagaa ccctgaaaca agaggaggag acacatatac gaaatgagca    840

ggtacggcaa agagcaaaag aatgttccca agctctcagt ctgattcttg acattgatca    900

tggaaagcca gtgaagaatg cattagattt aaagtttgat atggaacaac tgaaggactc    960

tattgatagg gaaaaaatag cagtaattgg acattctttt ggtggagcaa cggttattca   1020

gactcttagt gaagatcaga gattcagatg tggtattgcc ctggatgcat ggatgtttcc   1080

actgggtgat gaagtatatt ccagaattcc tcagcccctc ttttttatca actctgaata   1140

tttccaatat cctgctaata tcataaaaat gaaaaaatgc tactcacctg ataaagaaag   1200

aaagatgatt acaatcaggg gttcagtcca ccagaatttt gctgacttca cttttgcaac   1260

tggcaaaata attggacaca tgctcaaatt aaagggagac atagattcaa atgtagctat   1320

tgatcttagc aacaaagctt cattagcatt cttacaaaag catttaggac ttcataaaga   1380

ttttgatcag tgggactgct tgattgaagg agatgatgag aatcttattc cagggaccaa   1440

cattaacaca accaatcaac acatcatgtt acagaactct tcaggaatag agaaatacaa   1500

ttaggattaa aataggtttt tt                                            1522


<210>  3245
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  3245

Met Val Pro Pro Lys Leu His Val Leu Phe Cys Leu Cys Gly Cys Leu 
1               5                   10                  15


Ala Val Val Tyr Pro Phe Asp Trp Gln Tyr Ile Asn Pro Val Ala His 
            20                  25                  30


Met Lys Ser Ser Ala Trp Val Asn Lys Ile Gln Val Leu Met Ala Ala 
        35                  40                  45


Ala Ser Phe Gly Gln Thr Lys Ile Pro Arg Gly Asn Gly Pro Tyr Ser 
    50                  55                  60


Val Gly Cys Thr Asp Leu Met Phe Asp His Thr Asn Lys Gly Thr Phe 
65                  70                  75                  80


Leu Arg Leu Tyr Tyr Pro Ser Gln Asp Asn Asp Arg Leu Asp Thr Leu 
                85                  90                  95


Trp Ile Pro Asn Lys Glu Tyr Phe Trp Gly Leu Ser Lys Phe Leu Gly 
            100                 105                 110


Thr His Trp Leu Met Gly Asn Ile Leu Arg Leu Leu Phe Gly Ser Met 
        115                 120                 125


Thr Thr Pro Ala Asn Trp Asn Ser Pro Leu Arg Pro Gly Glu Lys Tyr 
    130                 135                 140


Pro Leu Val Val Phe Ser His Gly Leu Gly Ala Phe Arg Thr Leu Tyr 
145                 150                 155                 160


Ser Ala Ile Gly Ile Asp Leu Ala Ser His Gly Phe Ile Val Ala Ala 
                165                 170                 175


Val Glu His Arg Asp Arg Ser Ala Ser Ala Thr Tyr Tyr Phe Lys Asp 
            180                 185                 190


Gln Ser Ala Ala Glu Ile Gly Asp Lys Ser Trp Leu Tyr Leu Arg Thr 
        195                 200                 205


Leu Lys Gln Glu Glu Glu Thr His Ile Arg Asn Glu Gln Val Arg Gln 
    210                 215                 220


Arg Ala Lys Glu Cys Ser Gln Ala Leu Ser Leu Ile Leu Asp Ile Asp 
225                 230                 235                 240


His Gly Lys Pro Val Lys Asn Ala Leu Asp Leu Lys Phe Asp Met Glu 
                245                 250                 255


Gln Leu Lys Asp Ser Ile Asp Arg Glu Lys Ile Ala Val Ile Gly His 
            260                 265                 270


Ser Phe Gly Gly Ala Thr Val Ile Gln Thr Leu Ser Glu Asp Gln Arg 
        275                 280                 285


Phe Arg Cys Gly Ile Ala Leu Asp Ala Trp Met Phe Pro Leu Gly Asp 
    290                 295                 300


Glu Val Tyr Ser Arg Ile Pro Gln Pro Leu Phe Phe Ile Asn Ser Glu 
305                 310                 315                 320


Tyr Phe Gln Tyr Pro Ala Asn Ile Ile Lys Met Lys Lys Cys Tyr Ser 
                325                 330                 335


Pro Asp Lys Glu Arg Lys Met Ile Thr Ile Arg Gly Ser Val His Gln 
            340                 345                 350


Asn Phe Ala Asp Phe Thr Phe Ala Thr Gly Lys Ile Ile Gly His Met 
        355                 360                 365


Leu Lys Leu Lys Gly Asp Ile Asp Ser Asn Val Ala Ile Asp Leu Ser 
    370                 375                 380


Asn Lys Ala Ser Leu Ala Phe Leu Gln Lys His Leu Gly Leu His Lys 
385                 390                 395                 400


Asp Phe Asp Gln Trp Asp Cys Leu Ile Glu Gly Asp Asp Glu Asn Leu 
                405                 410                 415


Ile Pro Gly Thr Asn Ile Asn Thr Thr Asn Gln His Ile Met Leu Gln 
            420                 425                 430


Asn Ser Ser Gly Ile Glu Lys Tyr Asn 
        435                 440


<210>  3246
<211>  1420
<212>  DNA
<213>  Homo sapiens

<400>  3246
atgcaacttt ttaccatcgt cccttattac aagctctttg aggttgagaa cagctgccac     60

atccttactc cctcctcagc tctccaattt tgcttccagc cagtctatac cttacttttc    120

agccacaaag atattgctac tcagagtgtg ggctgttctc acatttcaat gcactcacct    180

ggagggctta ccacaacaaa gatggccgga cccctgccca gagtttcaga ttctttgttt    240

tctgccatgg aattggccaa aatgtcagac atgacaaagc ttcaccaagc tgtggctgca    300

ggagactaca gcttagtgaa gaagattttg aagaaaggtc tctgtgaccc aaactacaaa    360

gatgtagact ggaatgaccg gaccccactt cactgggctg caatcaaagg gcaaatggag    420

gtgatacggc tcctgataga atatggagcc aggccctgcc tggttactag tgtgggctgg    480

accccagctc attttgcagc agaagcaggc catctgaata tactcaaaac tctccatgca    540

ttgcacgctg ccatcgacgc ccctgacttc tttggagaca caccgaagag gattgcacag    600

atctatggac agaaagcctg tgtggcattt ctggaaaagg cagagcccga gtgccaggac    660

caccgttgcg ctgcccagca gaaggggctg cctctggatg agcgtgatga agactgggat    720

gccaagaaaa gggagctgga gctgtctctt ccttccctaa atcaaaacat gaataaaaag    780

aataagaaaa gtcgaggccc caccaggccc agcaatacca aggggaggag agtatgagaa    840

ctcaacctta tgttttctgg caaggaactt tccctggtgc cagaaatgag gctgttaggc    900

atggtggcct ttccatgact ttactcatag acccttaccc acctggcttc tgcccatgga    960

cctgtcatta ggtgctgtcc acatgggctg ttgtttcctg gctagcacct actgtgtaca   1020

ataattaccg ggaaaggaca aaacctgctt gcattttgtc atcagtggtt tgcacagtca   1080

gcatcttttg acccctgccc cccaacaata atagaatttc aggagacaag gaaactctgg   1140

catgaattaa cttcatccct gataacgatc gagagataat gtaaaataat gaacatgtga   1200

ttataggtct actttttcaa ctgtaaattt gggaaaatta aattcagatc agataattcc   1260

aataaaaaat tgcatccaaa ttgagatgca aaatacacat tagatttcaa acacttagta   1320

caaaaatata aaatgtctcc ttaataatac ttaatattga ttccacattg aaatgataat   1380

attttggata ttgcgttgaa taagatatat taccaaaatg                         1420


<210>  3247
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  3247

Met Gln Leu Phe Thr Ile Val Pro Tyr Tyr Lys Leu Phe Glu Val Glu 
1               5                   10                  15


Asn Ser Cys His Ile Leu Thr Pro Ser Ser Ala Leu Gln Phe Cys Phe 
            20                  25                  30


Gln Pro Val Tyr Thr Leu Leu Phe Ser His Lys Asp Ile Ala Thr Gln 
        35                  40                  45


Ser Val Gly Cys Ser His Ile Ser Met His Ser Pro Gly Gly Leu Thr 
    50                  55                  60


Thr Thr Lys Met Ala Gly Pro Leu Pro Arg Val Ser Asp Ser Leu Phe 
65                  70                  75                  80


Ser Ala Met Glu Leu Ala Lys Met Ser Asp Met Thr Lys Leu His Gln 
                85                  90                  95


Ala Val Ala Ala Gly Asp Tyr Ser Leu Val Lys Lys Ile Leu Lys Lys 
            100                 105                 110


Gly Leu Cys Asp Pro Asn Tyr Lys Asp Val Asp Trp Asn Asp Arg Thr 
        115                 120                 125


Pro Leu His Trp Ala Ala Ile Lys Gly Gln Met Glu Val Ile Arg Leu 
    130                 135                 140


Leu Ile Glu Tyr Gly Ala Arg Pro Cys Leu Val Thr Ser Val Gly Trp 
145                 150                 155                 160


Thr Pro Ala His Phe Ala Ala Glu Ala Gly His Leu Asn Ile Leu Lys 
                165                 170                 175


Thr Leu His Ala Leu His Ala Ala Ile Asp Ala Pro Asp Phe Phe Gly 
            180                 185                 190


Asp Thr Pro Lys Arg Ile Ala Gln Ile Tyr Gly Gln Lys Ala Cys Val 
        195                 200                 205


Ala Phe Leu Glu Lys Ala Glu Pro Glu Cys Gln Asp His Arg Cys Ala 
    210                 215                 220


Ala Gln Gln Lys Gly Leu Pro Leu Asp Glu Arg Asp Glu Asp Trp Asp 
225                 230                 235                 240


Ala Lys Lys Arg Glu Leu Glu Leu Ser Leu Pro Ser Leu Asn Gln Asn 
                245                 250                 255


Met Asn Lys Lys Asn Lys Lys Ser Arg Gly Pro Thr Arg Pro Ser Asn 
            260                 265                 270


Thr Lys Gly Arg Arg Val 
        275


<210>  3248
<211>  2578
<212>  DNA
<213>  Homo sapiens

<400>  3248
aagggcaaat ggaggtgata cggctcctga tagaatatgg agccaggccc tgcctggtta     60

ctagtgtggg ctggacccca gctcattttg cagcagaagc aggccatctg aatatactca    120

aaactctcca tgcattgcac gctgccatcg acgcccctga cttctttgga gacacaccga    180

agaggattgc acagatctat ggacagaaag cctgtgtggc atttctggaa aagggaatag    240

aattttgact ctatataaat caagaaacgc ctgacttctt tagtagtttg tatttgcaag    300

atctaagatc atggtaaaca ttaggtccta aaatcttggg gaaggacaac atgtccttcc    360

tctgacttgt tagcaatcaa attgagtagg ttttaaatgt ctgttaattg gaagggtttg    420

ttatttcatt ttcagccaaa ggagagaggt gcattttaag tatcagaatt agatcagctt    480

tgagtttgta ctaaatttgg aatgtaatag attttcataa attacgtgtg cctttttgga    540

aatgtcaact gtctttatgt ctgcttgtaa aagtttcaaa atatgttttt ctctcaaaaa    600

ggcaacgtta tttcatttgc ttgaatatta tgataggaac gcttactgat attacttgat    660

agttttatat agccttggaa ctttaacata taatatagca gtattaatca tgatagttgt    720

acttctttga aacattaaat ttgaggaaac taatctatgt aattgtctcc acttcttcac    780

ctctcaccca cgcttcagac ttcttccctg atccccatac tgaatcagct gtcactcaag    840

tcattaggga gctcctcacg ctaaatcaat tgcctcttct caattcacat cttacctcca    900

cttaattcgg tatttaatat tcctgaaact cttctccctt gttttatctg atgctattct    960

cttttagttt ttcttctact tctctgataa ttccttatga cttttaaaat gtgctttttc   1020

taagaataaa tcttatgata tgttcttgcg tgccttttaa atgctgacat tccttagggt   1080

cctgcccttg gctgtcctct actgactctc tctaagtaat cccagcccct ccctagtgac   1140

cagggatcaa catgaaatat gatcccagca taactgaaat gcaggagggg tgcttgcctc   1200

caaatagtgg ggagtgctat taccaagaaa agtaggcaga cagtgttgag ccagcaaaaa   1260

caataaaggt cagtcacatc acgtgtgagt catttctact tattatcagc tcccactaag   1320

aacttccctg acagagcgtt tagggagaag aatcctgaat taagggggga ttaacctgga   1380

tcttgaaagc tagctggcta atgaaggagg gagaaaaact gttgatttag agtgaaggca   1440

ccaacttgga aatgtgcata ggttgtgtgt atatgtgaga aggtgaggga tagtggagtg   1500

cagggatgag tggcctggct aggcagagca ttcacactag agaggaatgg agcataaggt   1560

caggtgacgg ggtgggtgac cacagtgaac taggcaagca gaagagtgtg agctcatcag   1620

gggagtcaca agctgaaaca gatgcattag caatttattt gtgtagtaga ggagttggca   1680

gtggtactgc gtgggattga agactgctag actttaggca aggggatcac ttaaggaatt   1740

tcttattgat tcacattttg agtaagttgg ctcctgggct aggtgatgaa gataaaggat   1800

ataagagaac ttcaaaagaa gcctagacca tatgtgatca ttttctgaat atcctaggga   1860

atgttgtgaa acaattcagc ttttgattca gccccccaag tgataaacct ctcatttagc   1920

aaatattttt gagttctact atgtgtatgt cattgagtta gacactaaaa acaacctaaa   1980

ataaaccaga tacagtgctg gacatcaaga aggttaactg tgtgggagac gaaataactt   2040

gtttacataa ataacactaa tacaagacag agagtgacta ggcagaggaa agacatggtg   2100

tggtctgaag attgaaaggt cacttccagc ttagggtgag ggactagtga gtttgctgtc   2160

ctttgaatga actgtgcttt taataatggt ttgcacttaa aatgctattt gccttcccta   2220

taccattatc tatcctctta aattccattt gtcctcatat tggttcaaaa gtgacttttc   2280

caagtacctt taagcaagtc acatactcac cattggcctc atacaaaact gtatatgtgt   2340

gtatttccca ttgtctatgt gtgtataatg ctctatttat ttatccatcc atgtatccat   2400

ttacaattat atgtattttt acagaatcca tacatacgta taatacatat gtgattgtga   2460

gtgattctca ttttgttcct tatatgtttc tgtactttta aattttatac aaggaacaca   2520

catcactttt atgattatga aaaataaaac taaaaataaa cgaaaacagt ctcgcaat     2578


<210>  3249
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  3249

Met Glu Val Ile Arg Leu Leu Ile Glu Tyr Gly Ala Arg Pro Cys Leu 
1               5                   10                  15


Val Thr Ser Val Gly Trp Thr Pro Ala His Phe Ala Ala Glu Ala Gly 
            20                  25                  30


His Leu Asn Ile Leu Lys Thr Leu His Ala Leu His Ala Ala Ile Asp 
        35                  40                  45


Ala Pro Asp Phe Phe Gly Asp Thr Pro Lys Arg Ile Ala Gln Ile Tyr 
    50                  55                  60


Gly Gln Lys Ala Cys Val Ala Phe Leu Glu Lys Gly Ile Glu Phe 
65                  70                  75


<210>  3250
<211>  791
<212>  DNA
<213>  Homo sapiens

<400>  3250
gggaaggatc tgctgcagaa ctctctcctt ggtgctggta tgatctccct gtttacagaa     60

gaggaaactt gagaagttaa gcaacctgcc aaaggtctta gagcctgaaa gattagccca    120

tcgaccaaat ccagccaggc tttacagcca gcacaaacat cggtcaggtg gcctagggca    180

agtcattcaa cctctcagaa cttcagtttg tgatgtcagt tggggataat gatacttgcc    240

ttgcagggaa ggaagagaca gctccagctc ccttttcttg gcatcccagt cttcatcacg    300

ctcatccaga ggcagcccct tctgctgggc agcgcaacgg tggtcctggc actcgggctc    360

tgccctagga aagaagagag agccttctga acttggatca ggaggacctg ttccagcctg    420

ggaatcggcc tttattcaca ggttctgcac accgcagttc agttgagaag gaaggaggcc    480

aagtttgagc atttccaagc atacacttag ggaaggtctc agacactaaa gaaactactt    540

ggaggtggag aaaaattgtg ggacccgagt gagatgttaa cagactcaaa gatagtcact    600

cagcttgaag aaaatgctcc tgattcttga agtgctcaca tttatagagc aacctgcaga    660

ttattgcgag actgttttcg tttattttta gttttatttt tcataatcat aaaagtgatg    720

tgtgttcctt gtataaaatt taaaagtaca gaaacatata aggaacaaaa tgagaatcac    780

tcacaatcac a                                                         791


<210>  3251
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  3251

Met Ile Leu Ala Leu Gln Gly Arg Lys Arg Gln Leu Gln Leu Pro Phe 
1               5                   10                  15


Leu Gly Ile Pro Val Phe Ile Thr Leu Ile Gln Arg Gln Pro Leu Leu 
            20                  25                  30


Leu Gly Ser Ala Thr Val Val Leu Ala Leu Gly Leu Cys Pro Arg Lys 
        35                  40                  45


Glu Glu Arg Ala Phe 
    50


<210>  3252
<211>  438
<212>  DNA
<213>  Homo sapiens

<400>  3252
tgcagctgtt ctcttagtta cattggcaga ttgtgtgttg tcaatgttga ctattgctta     60

gggaaccaca gtatatcagt gcatggcctc tgcctggccc tttcgcacaa ttgtaactgt    120

agcggtctgc aaagatatga aaggaacatc tgtgagatag atactgaaga ctgcaaatct    180

gcgtcctgca aaaatggaac aactagtaca catttaaggg gatatttctt ccgcaagtgt    240

gtcccaggat ttaaagaatt tgtcagtgtg gccatctcgt cttgtgtttt ctttttgggg    300

aggttttgac tacgaattca atcactttac ctatggatca acaggtaccc agagtatgct    360

cttctcatga caaatggcaa aatcccaatg agtgaaaata tttgatgtct aataaagcct    420

cagcttacaa ctggtaca                                                  438


<210>  3253
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  3253

Cys Ser Cys Ser Leu Ser Tyr Ile Gly Arg Leu Cys Val Val Asn Val 
1               5                   10                  15


Asp Tyr Cys Leu Gly Asn His Ser Ile Ser Val His Gly Leu Cys Leu 
            20                  25                  30


Ala Leu Ser His Asn Cys Asn Cys Ser Gly Leu Gln Arg Tyr Glu Arg 
        35                  40                  45


Asn Ile Cys Glu Ile Asp Thr Glu Asp Cys Lys Ser Ala Ser Cys Lys 
    50                  55                  60


Asn Gly Thr Thr Ser Thr His Leu Arg Gly Tyr Phe Phe Arg Lys Cys 
65                  70                  75                  80


Val Pro Gly Phe Lys Glu Phe Val Ser Val Ala Ile Ser Ser Cys Val 
                85                  90                  95


Phe Phe Leu Gly Arg Phe 
            100


<210>  3254
<211>  5191
<212>  DNA
<213>  Homo sapiens

<400>  3254
agaaccctcg cgccctgcgt cgtgctggca cttttaccgg ccgggcctta gagcgcagcc     60

tgtagccggg cgccatcttt gacgctggca gtcttggttt tctgctagtg ctgctgctgc    120

tgggaggacg acggacggca gcggccaagc gagaagaaag acgtggcagc aagcgggagt    180

cggggatagt gtcatcggtt cgggtcccac tactttggag cttgtctcaa actccacata    240

cagaaagcca ccgaccttat tccggtatcc tacacccatt ccccaccctc attacactcc    300

cacccctggc cctcagcgtg ggagtcaaga gcaacaggga cacttccgta ctccttgtag    360

gattggtgaa accgtaatga cgaacacccc taaactccca taattggtgc ggattcctgt    420

ggggaaggcc tatactgttg acatcttcca ggccatctca aggttctgga ccttgagaag    480

gaggctgtgg aactagagat agtgatgctt tttaggattt ggggatattc cctgcccaaa    540

aaattcctgg aaaattgact agtattaagt ctatggaaga tggatttttt ttcatgatcc    600

tttgactctc aagttcatct ttaaatgaac tctttttttt gttttgtttt tgaggagata    660

actaacccta gctgtctcca gtctgacaaa ggttatttga atggacttaa tctcccagta    720

gttgggagat gttttaaaaa cacatgctgt gtttgaattg tggctgagag gttttcttgg    780

caatgtgagg aggaaaattt tttctgcttc attattatta attcatggat tgagtgttgg    840

ttcgacctac aggcgtaata gattggaact cagtgaagac acagacgttc ctgttgagag    900

caatcagcta atgattacag tttaaagaca atttctgtga tcaagttgtc atttggaaga    960

ttaaacccat ttcacgagga cttggagcct ggtccttgct ttgaggaagc agtggcttgt   1020

ttcaagaagc cacttctgat ctaagaatct acccagcatg cctaatcaag gagaagactg   1080

ctattttttt ttctattcta catgtaccaa aggtgacagc tgcccattcc gtcactgtga   1140

agctgcacta ggcaatgaaa ctgtttgcac attatggcaa gaagggcgct gttttcgacg   1200

ggtgtgcagg tttcggcaca tggagattga taaaaaacgc agtgaaattc cttgttattg   1260

ggaaaatcag ccaacaggat gtcaaaaatt aaactgcgct ttccatcaca atagaggacg   1320

atatgttgat ggccttttcc tacctccgag caaaagtgtg ttgcccactg tgcctgagtc   1380

accagaagag gaagtgaagg ctagccaact ttcagttcag cagaacaaat tgtctgtcca   1440

gtccaatcct tcccctcagc tgcggagcgt tatgaaagta gaaagttccg aaaatgttcc   1500

tagccccaag catccaccag ttgtaattaa tgctgcagat gatgatgaag atgatgatga   1560

tcagttttct gaggaaggtg atgaaaccaa aacacctacc ctgcaaccaa ctcctgaagt   1620

tcacaatgga ttacgagtga cttctgtccg gaaacctgca gtcaatataa agcaaggtga   1680

atgtttgcat tttggaataa aaactcttga ggaaattaag tcaaagaaaa tgaaggaaaa   1740

atctgaggag caaggtgagg gttcttcagg agtttccagt cttttactcc accctgagcc   1800

tgttccaggt cctgaaaaag aaaatgtcag gactgtggtg aggacagtaa ctctctccac   1860

caaacaagga gaagaaccct tggttagatt gggccttact gagacactgg ggaaacgaaa   1920

attttcgaca ggcggtgaca gtgatcctcc attaaagcgc agcctggcac agaggctagg   1980

gaagaaagtt gaagctccag aaactaacac tgacgaaaca ccaaagaaag ctcaagtttc   2040

caagtctctt aaggagcgat taggcatgtc agctgatcca aataatgagg acgcaacaga   2100

taaagttaat aaagttggtg agatccatgt gaagacatta gaagaaatgc ttcttgaaag   2160

agccagtcag aaacatgggg aatcgcaaac taaactcaag acagaaggac cttcaaaaac   2220

tgatgattct acttcaggag caagaagctc ctccactatc cgtatcaaaa ccttctctga   2280

ggtcctggct gaagaagaac ataggcagca ggaagcagag agacaaaaaa gcaaaaagga   2340

tacaacttgc atcaagctaa agactgatag tgaaattaaa aaaacagtag ttttgccacc   2400

cattgttgcc agcaaaggac aatcagagga gcctgcaggt aaaacaaagt ccatgcagga   2460

ggtgcacatg aagacggtgg aagaaattaa actggagaag gcactgaggg tgcagcagag   2520

ctctgagagc agcaccagct ccccgtctca acatgaggcc actccagggg caaggttgct   2580

actgcgaatc accaaaagaa catggaggaa agaagagaag aaacttcagg aaggaaatga   2640

agttgatttt ctgagccgtg ttagaatgga agctacagag gcttcagttg agaccacagg   2700

agttgacatc actaaaattc aagtcaagag atgtgagatc atgagagaga cgcgcatgca   2760

gaaacagcag gagagggaaa aatcagtctt gacacctctt cagggagatg tagcctcttg   2820

caatacccaa gtggcagaga aaccagtgct cactgctgtg ccaggaatca catggcacct   2880

gaccaagcag cttcccacaa agtcatccca gaaggtggag gtagaaacct cagggattgc   2940

agactcatta ttgaatgtga aatggtcagc acagaccttg gaaaaaaggg gtgaagctaa   3000

acccacagtg aacgtgaagc aatctgtggt taaagttgtg tcatccccca aattggcccc   3060

aaaacgtaag gcagtggaga tgcaccctgc tgtcactgcc gctgtgaagc cactcagctc   3120

cagcagcgtc ctacaggaac ccccagccaa aaaggcagct gtggatgctg ttgtcctgct   3180

tgtctctgag gacaaatcag tcactgtgcc tgaaacagaa aatcctagag acagtcttgt   3240

gctgcctcta acccagtcct cttcagattc ctcacccccg gaggtgtctg gcccttcctc   3300

atcccaaatg agcatgaaaa ctcgccgact cagctctgcc tcaacaggaa agcccccact   3360

ctctgtggag gatgattttg agaaactaac atgggagatt tcaggaggca aattggaagc   3420

tgagattgac ctggatcctg ggaaagatga agatgacctt ccgcttgagc tatgagaaat   3480

gattgatagc tgaaggtggt agtgaggaca ctttaaaaaa aaatcgccaa aaaactggac   3540

ttagtttcat ctattgtaac atttacctga gatgatcatt tctttagtct agaatttgcc   3600

ccaaatcaga agtatacctc tgaattatct gtatgtgtcc tggattcctt ggggtcagat   3660

ttttaaagtt actttataac cattttgtcc atttgatgcc attgtttatc atcttttgag   3720

aaaaaagttc tgtcataccc ttctctccac aaaaaagaga ctgagaggga gatcaagtga   3780

aagggtgcaa gcaaacttag tgactccttg aggtgtttgt cagttttggc ttttttctcc   3840

tttgttgtat tctttatgta ttgtcttgat gtacttaata ttacctgagt ttgaaatgga   3900

tgaagacagc tgctaccatt aaggaccaaa ttttatgcta ccactaaaca aaaataccca   3960

ctcagtctgt gttagattgt atgtcttttt aaaggtattt agagattcaa ctaagcttta   4020

aagagggctg agcagctcag gaagcctgta atgtgggcat aactctttgg acctgatctt   4080

gatgcttctg ctgctctgtt ggcctctgaa gagcaatatc taatttatta ttactgtaat   4140

tttttaaaag gctttaaagt gcctcagggg tcccctgaaa ctaattttct atttctggga   4200

ttccctggat tcattatatg agatggtgac atgattagag gaattctttt ttagtatgaa   4260

aattgtccct tttcttcttc agtacttgcc tccttgctgg cattgaatta acacagggac   4320

aaaatatggt taatttttta tttctaattc tcccaacaaa cccctgttgc ccagtattta   4380

tgtggtggcc tttaaccacc tgagggaaaa aatgagctta ttcaagctgc caatatttat   4440

ctatgggctg tagcagtaca ctgaattgta ctgtgccagg gatattgaga tgctctgggg   4500

gtatattgta tacctgccag ttttcttcat ttctgaattg agttttcttt tcttgatgtt   4560

ggtttccttc atatcacctc aaggtttaga tttgtgaagg aataagcatg atggaaataa   4620

tagtcttgaa aggagatatg ttgtatataa tcaggaggaa gaggaaggaa ggacttaccc   4680

attttgatat tttgctgtag gtggccagtt ttgtttctca tagggaaatc tgacccccac   4740

ctgtcatgtt ggctcctaag gaactgctgt tgtaagcggc tcatcaagag ttgaacttca   4800

cgtagccttg ttgggaatat ggaaaaggaa gaaagccaca ggactgccca ttcagtcttg   4860

ttaagattgg gatgattctg cacaagcaaa aatgacttga aatttatgta tcgacacacc   4920

tctaccaatc catcttcagc tgactgaatg ttgtatgata gcccttctcc aaagcagggg   4980

tagaatgttc aggtttcacc acggattttc tacttatttc gcttttggaa tcagcttaca   5040

gattccaggt cccttttgta gatattcttt attcttttgc ttttttaaaa aataaactgg   5100

tattagtcaa tgtttcgtgt tccgcattat ttgaaccatt tgcccttaca gaaagagaaa   5160

tacttgtttg tgttttaaat aaaactgatg t                                  5191


<210>  3255
<211>  805
<212>  PRT
<213>  Homo sapiens

<400>  3255

Met Pro Asn Gln Gly Glu Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys 
1               5                   10                  15


Thr Lys Gly Asp Ser Cys Pro Phe Arg His Cys Glu Ala Ala Leu Gly 
            20                  25                  30


Asn Glu Thr Val Cys Thr Leu Trp Gln Glu Gly Arg Cys Phe Arg Arg 
        35                  40                  45


Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile 
    50                  55                  60


Pro Cys Tyr Trp Glu Asn Gln Pro Thr Gly Cys Gln Lys Leu Asn Cys 
65                  70                  75                  80


Ala Phe His His Asn Arg Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro 
                85                  90                  95


Pro Ser Lys Ser Val Leu Pro Thr Val Pro Glu Ser Pro Glu Glu Glu 
            100                 105                 110


Val Lys Ala Ser Gln Leu Ser Val Gln Gln Asn Lys Leu Ser Val Gln 
        115                 120                 125


Ser Asn Pro Ser Pro Gln Leu Arg Ser Val Met Lys Val Glu Ser Ser 
    130                 135                 140


Glu Asn Val Pro Ser Pro Lys His Pro Pro Val Val Ile Asn Ala Ala 
145                 150                 155                 160


Asp Asp Asp Glu Asp Asp Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu 
                165                 170                 175


Thr Lys Thr Pro Thr Leu Gln Pro Thr Pro Glu Val His Asn Gly Leu 
            180                 185                 190


Arg Val Thr Ser Val Arg Lys Pro Ala Val Asn Ile Lys Gln Gly Glu 
        195                 200                 205


Cys Leu His Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys 
    210                 215                 220


Met Lys Glu Lys Ser Glu Glu Gln Gly Glu Gly Ser Ser Gly Val Ser 
225                 230                 235                 240


Ser Leu Leu Leu His Pro Glu Pro Val Pro Gly Pro Glu Lys Glu Asn 
                245                 250                 255


Val Arg Thr Val Val Arg Thr Val Thr Leu Ser Thr Lys Gln Gly Glu 
            260                 265                 270


Glu Pro Leu Val Arg Leu Gly Leu Thr Glu Thr Leu Gly Lys Arg Lys 
        275                 280                 285


Phe Ser Thr Gly Gly Asp Ser Asp Pro Pro Leu Lys Arg Ser Leu Ala 
    290                 295                 300


Gln Arg Leu Gly Lys Lys Val Glu Ala Pro Glu Thr Asn Thr Asp Glu 
305                 310                 315                 320


Thr Pro Lys Lys Ala Gln Val Ser Lys Ser Leu Lys Glu Arg Leu Gly 
                325                 330                 335


Met Ser Ala Asp Pro Asn Asn Glu Asp Ala Thr Asp Lys Val Asn Lys 
            340                 345                 350


Val Gly Glu Ile His Val Lys Thr Leu Glu Glu Met Leu Leu Glu Arg 
        355                 360                 365


Ala Ser Gln Lys His Gly Glu Ser Gln Thr Lys Leu Lys Thr Glu Gly 
    370                 375                 380


Pro Ser Lys Thr Asp Asp Ser Thr Ser Gly Ala Arg Ser Ser Ser Thr 
385                 390                 395                 400


Ile Arg Ile Lys Thr Phe Ser Glu Val Leu Ala Glu Glu Glu His Arg 
                405                 410                 415


Gln Gln Glu Ala Glu Arg Gln Lys Ser Lys Lys Asp Thr Thr Cys Ile 
            420                 425                 430


Lys Leu Lys Thr Asp Ser Glu Ile Lys Lys Thr Val Val Leu Pro Pro 
        435                 440                 445


Ile Val Ala Ser Lys Gly Gln Ser Glu Glu Pro Ala Gly Lys Thr Lys 
    450                 455                 460


Ser Met Gln Glu Val His Met Lys Thr Val Glu Glu Ile Lys Leu Glu 
465                 470                 475                 480


Lys Ala Leu Arg Val Gln Gln Ser Ser Glu Ser Ser Thr Ser Ser Pro 
                485                 490                 495


Ser Gln His Glu Ala Thr Pro Gly Ala Arg Leu Leu Leu Arg Ile Thr 
            500                 505                 510


Lys Arg Thr Trp Arg Lys Glu Glu Lys Lys Leu Gln Glu Gly Asn Glu 
        515                 520                 525


Val Asp Phe Leu Ser Arg Val Arg Met Glu Ala Thr Glu Ala Ser Val 
    530                 535                 540


Glu Thr Thr Gly Val Asp Ile Thr Lys Ile Gln Val Lys Arg Cys Glu 
545                 550                 555                 560


Ile Met Arg Glu Thr Arg Met Gln Lys Gln Gln Glu Arg Glu Lys Ser 
                565                 570                 575


Val Leu Thr Pro Leu Gln Gly Asp Val Ala Ser Cys Asn Thr Gln Val 
            580                 585                 590


Ala Glu Lys Pro Val Leu Thr Ala Val Pro Gly Ile Thr Trp His Leu 
        595                 600                 605


Thr Lys Gln Leu Pro Thr Lys Ser Ser Gln Lys Val Glu Val Glu Thr 
    610                 615                 620


Ser Gly Ile Ala Asp Ser Leu Leu Asn Val Lys Trp Ser Ala Gln Thr 
625                 630                 635                 640


Leu Glu Lys Arg Gly Glu Ala Lys Pro Thr Val Asn Val Lys Gln Ser 
                645                 650                 655


Val Val Lys Val Val Ser Ser Pro Lys Leu Ala Pro Lys Arg Lys Ala 
            660                 665                 670


Val Glu Met His Pro Ala Val Thr Ala Ala Val Lys Pro Leu Ser Ser 
        675                 680                 685


Ser Ser Val Leu Gln Glu Pro Pro Ala Lys Lys Ala Ala Val Asp Ala 
    690                 695                 700


Val Val Leu Leu Val Ser Glu Asp Lys Ser Val Thr Val Pro Glu Thr 
705                 710                 715                 720


Glu Asn Pro Arg Asp Ser Leu Val Leu Pro Leu Thr Gln Ser Ser Ser 
                725                 730                 735


Asp Ser Ser Pro Pro Glu Val Ser Gly Pro Ser Ser Ser Gln Met Ser 
            740                 745                 750


Met Lys Thr Arg Arg Leu Ser Ser Ala Ser Thr Gly Lys Pro Pro Leu 
        755                 760                 765


Ser Val Glu Asp Asp Phe Glu Lys Leu Thr Trp Glu Ile Ser Gly Gly 
    770                 775                 780


Lys Leu Glu Ala Glu Ile Asp Leu Asp Pro Gly Lys Asp Glu Asp Asp 
785                 790                 795                 800


Leu Pro Leu Glu Leu 
                805


<210>  3256
<211>  4583
<212>  DNA
<213>  Homo sapiens

<400>  3256
gcacttttac cggccgggcc ttagagcgca gcctgtagcc gggcgccatc tttgacgctg     60

gcagtcttgg ttttctgcta gtgctgctgc tgctgggagg acgacggacg gcagcggcca    120

agcgagaaga aagacgtggc agcaagcggg agtcggggat agtgtcatcg gttcggtgat    180

gctttttagg atttggggat attccctgcc caaaaaattc ctggaaaatt gactagtatt    240

aagtgcgtaa tagattggaa ctcagtgaag acacagacgt tcctgttgag agcaatcagc    300

taatgattac agtttaaaga caatttctgt gatcaagttg tcatttggaa gattaaaccc    360

atttcacgag gacttggagc ctggtccttg ctttgaggaa gcagtggctt gtttcaagaa    420

gccacttctg atctaagaat ctacccagca tgcctaatca aggagaagac tgctattttt    480

ttttctattc tacatgtacc aaaggtgaca gctgcccatt ccgtcactgt gaagctgcac    540

taggcaatga aactgtttgc acattatggc aagaagggcg ctgttttcga cgggtgtgca    600

ggtttcggca catggagatt gataaaaaac gcagtgaaat tccttgttat tgggaaaatc    660

agccaacagg atgtcaaaaa ttaaactgcg ctttccatca caatagagga cgatatgttg    720

atggcctttt cctacctccg agcaaaagtg tgttgcccac tgtgcctgag tcaccagaag    780

aggaagtgaa ggctagccaa ctttcagttc agcagaacaa attgtctgtc cagtccaatc    840

cttcccctca gctgcggagc gttatgaaag tagaaagttc cgaaaatgtt cctagcccca    900

agcatccacc agttgtaatt aatgctgcag atgatgatga agatgatgat gatcagtttt    960

ctgaggaagg tgatgaaacc aaaacaccta ccctgcaacc aactcctgaa gttcacaatg   1020

gattacgagt gacttctgtc cggaaacctg cagtcaatat aaagcaaggt gaatgtttgc   1080

attttggaat aaaaactctt gaggaaatta agtcaaagaa aatgaaggaa aaatctgagg   1140

agcaaggtga gggttcttca ggagtttcca gtcttttact ccaccctgag cctgttccag   1200

gtcctgaaaa agaaaatgtc aggactgtgg tgaggacagt aactctctcc accaaacaag   1260

gagaagaacc cttggttaga ttgggcctta ctgagacact ggggaaacga aaattttcga   1320

caggcggtga cagtgatcct ccattaaagc gcagcctggc acagaggcta gggaagaaag   1380

ttgaagctcc agaaactaac actgacgaaa caccaaagaa agctcaagtt tccaagtctc   1440

ttaaggagcg attaggcatg tcagctgatc caaataatga ggacgcaaca gataaagtta   1500

ataaagttgg tgagatccat gtgaagacat tagaagaaat gcttcttgaa agagccagtc   1560

agaaacatgg ggaatcgcaa actaaactca agacagaagg accttcaaaa actgatgatt   1620

ctacttcagg agcaagaagc tcctccacta tccgtatcaa aaccttctct gaggtcctgg   1680

ctgaagaaga acataggcag caggaagcag agagacaaaa aagcaaaaag gatacaactt   1740

gcatcaagct aaagactgat agtgaaatta aaaaaacagt agttttgcca cccattgttg   1800

ccagcaaagg acaatcagag gagcctgcag gtaaaacaaa gtccatgcag gaggtgcaca   1860

tgaagacggt ggaagaaatt aaactggaga aggcactgag ggtgcagcag agctctgaga   1920

gcagcaccag ctccccgtct caacatgagg ccactccagg ggcaaggttg ctactgcgaa   1980

tcaccaaaag aacatggagg aaagaagaga agaaacttca ggaaggaaat gaagttgatt   2040

ttctgagccg tgttagaatg gaagctacag aggcttcagt tgagaccaca ggagttgaca   2100

tcactaaaat tcaagtcaag agatgtgaga tcatgagaga gacgcgcatg cagaaacagc   2160

aggagaggga aaaatcagtc ttgacacctc ttcagggaga tgtagcctct tgcaataccc   2220

aagtggcaga gaaaccagtg ctcactgctg tgccaggaat cacatggcac ctgaccaagc   2280

agcttcccac aaagtcatcc cagaaggtgg aggtagaaac ctcagggatt gcagactcat   2340

tattgaatgt gaaatggtca gcacagacct tggaaaaaag gggtgaagct aaacccacag   2400

tgaacgtgaa gcaatctgtg gttaaagttg tgtcatcccc caaattggcc ccaaaacgta   2460

aggcagtgga gatgcaccct gctgtcactg ccgctgtgaa gccactcagc tccagcagcg   2520

tcctacagga acccccagcc aaaaaggcag ctgtggatgc tgttgtcctg cttgtctctg   2580

aggacaaatc agtcactgtg cctgaaacag aaaatcctag agacagtctt gtgctgcctc   2640

taacccagtc ctcttcagat tcctcacccc cggaggtgtc tggcccttcc tcatcccaaa   2700

tgagcatgaa aactcgccga ctcagctctg cctcaacagg aaagccccca ctctctgtgg   2760

aggatgattt tgagaaacta acatgggaga tttcaggagg caaattggaa gctgagattg   2820

acctggatcc tgggaaagat gaagatgacc ttccgcttga gctatgagaa atgattgata   2880

gctgaaggtg gtagtgagga cactttaaaa aaaaatcgcc aaaaaactgg acttagtttc   2940

atctattgta acatttacct gagatgatca tttctttagt ctagaatttg ccccaaatca   3000

gaagtatacc tctgaattat ctgtatgtgt cctggattcc ttggggtcag atttttaaag   3060

ttactttata accattttgt ccatttgatg ccattgttta tcatcttttg agaaaaaagt   3120

tctgtcatac ccttctctcc acaaaaaaga gactgagagg gagatcaagt gaaagggtgc   3180

aagcaaactt agtgactcct tgaggtgttt gtcagttttg gcttttttct cctttgttgt   3240

attctttatg tattgtcttg atgtacttaa tattacctga gtttgaaatg gatgaagaca   3300

gctgctacca ttaaggacca aattttatgc taccactaaa caaaaatacc cactcagtct   3360

gtgttagatt gtatgtcttt ttaaaggtat ttagagattc aactaagctt taaagagggc   3420

tgagcagctc aggaagcctg taatgtgggc ataactcttt ggacctgatc ttgatgcttc   3480

tgctgctctg ttggcctctg aagagcaata tctaatttat tattactgta attttttaaa   3540

aggctttaaa gtgcctcagg ggtcccctga aactaatttt ctatttctgg gattccctgg   3600

attcattata tgagatggtg acatgattag aggaattctt ttttagtatg aaaattgtcc   3660

cttttcttct tcagtacttg cctccttgct ggcattgaat taacacaggg acaaaatatg   3720

gttaattttt tatttctaat tctcccaaca aacccctgtt gcccagtatt tatgtggtgg   3780

cctttaacca cctgagggaa aaaatgagct tattcaagct gccaatattt atctatgggc   3840

tgtagcagta cactgaattg tactgtgcca gggatattga gatgctctgg gggtatattg   3900

tatacctgcc agttttcttc atttctgaat tgagttttct tttcttgatg ttggtttcct   3960

tcatatcacc tcaaggttta gatttgtgaa ggaataagca tgatggaaat aatagtcttg   4020

aaaggagata tgttgtatat aatcaggagg aagaggaagg aaggacttac ccattttgat   4080

attttgctgt aggtggccag ttttgtttct catagggaaa tctgaccccc acctgtcatg   4140

ttggctccta aggaactgct gttgtaagcg gctcatcaag agttgaactt cacgtagcct   4200

tgttgggaat atggaaaagg aagaaagcca caggactgcc cattcagtct tgttaagatt   4260

gggatgattc tgcacaagca aaaatgactt gaaatttatg tatcgacaca cctctaccaa   4320

tccatcttca gctgactgaa tgttgtatga tagcccttct ccaaagcagg ggtagaatgt   4380

tcaggtttca ccacggattt tctacttatt tcgcttttgg aatcagctta cagattccag   4440

gtcccttttg tagatattct ttattctttt gcttttttaa aaaataaact ggtattagtc   4500

aatgtttcgt gttccgcatt atttgaacca tttgccctta cagaaagaga aatacttgtt   4560

tgtgttttaa ataaaactga tgt                                           4583


<210>  3257
<211>  805
<212>  PRT
<213>  Homo sapiens

<400>  3257

Met Pro Asn Gln Gly Glu Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys 
1               5                   10                  15


Thr Lys Gly Asp Ser Cys Pro Phe Arg His Cys Glu Ala Ala Leu Gly 
            20                  25                  30


Asn Glu Thr Val Cys Thr Leu Trp Gln Glu Gly Arg Cys Phe Arg Arg 
        35                  40                  45


Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile 
    50                  55                  60


Pro Cys Tyr Trp Glu Asn Gln Pro Thr Gly Cys Gln Lys Leu Asn Cys 
65                  70                  75                  80


Ala Phe His His Asn Arg Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro 
                85                  90                  95


Pro Ser Lys Ser Val Leu Pro Thr Val Pro Glu Ser Pro Glu Glu Glu 
            100                 105                 110


Val Lys Ala Ser Gln Leu Ser Val Gln Gln Asn Lys Leu Ser Val Gln 
        115                 120                 125


Ser Asn Pro Ser Pro Gln Leu Arg Ser Val Met Lys Val Glu Ser Ser 
    130                 135                 140


Glu Asn Val Pro Ser Pro Lys His Pro Pro Val Val Ile Asn Ala Ala 
145                 150                 155                 160


Asp Asp Asp Glu Asp Asp Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu 
                165                 170                 175


Thr Lys Thr Pro Thr Leu Gln Pro Thr Pro Glu Val His Asn Gly Leu 
            180                 185                 190


Arg Val Thr Ser Val Arg Lys Pro Ala Val Asn Ile Lys Gln Gly Glu 
        195                 200                 205


Cys Leu His Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys 
    210                 215                 220


Met Lys Glu Lys Ser Glu Glu Gln Gly Glu Gly Ser Ser Gly Val Ser 
225                 230                 235                 240


Ser Leu Leu Leu His Pro Glu Pro Val Pro Gly Pro Glu Lys Glu Asn 
                245                 250                 255


Val Arg Thr Val Val Arg Thr Val Thr Leu Ser Thr Lys Gln Gly Glu 
            260                 265                 270


Glu Pro Leu Val Arg Leu Gly Leu Thr Glu Thr Leu Gly Lys Arg Lys 
        275                 280                 285


Phe Ser Thr Gly Gly Asp Ser Asp Pro Pro Leu Lys Arg Ser Leu Ala 
    290                 295                 300


Gln Arg Leu Gly Lys Lys Val Glu Ala Pro Glu Thr Asn Thr Asp Glu 
305                 310                 315                 320


Thr Pro Lys Lys Ala Gln Val Ser Lys Ser Leu Lys Glu Arg Leu Gly 
                325                 330                 335


Met Ser Ala Asp Pro Asn Asn Glu Asp Ala Thr Asp Lys Val Asn Lys 
            340                 345                 350


Val Gly Glu Ile His Val Lys Thr Leu Glu Glu Met Leu Leu Glu Arg 
        355                 360                 365


Ala Ser Gln Lys His Gly Glu Ser Gln Thr Lys Leu Lys Thr Glu Gly 
    370                 375                 380


Pro Ser Lys Thr Asp Asp Ser Thr Ser Gly Ala Arg Ser Ser Ser Thr 
385                 390                 395                 400


Ile Arg Ile Lys Thr Phe Ser Glu Val Leu Ala Glu Glu Glu His Arg 
                405                 410                 415


Gln Gln Glu Ala Glu Arg Gln Lys Ser Lys Lys Asp Thr Thr Cys Ile 
            420                 425                 430


Lys Leu Lys Thr Asp Ser Glu Ile Lys Lys Thr Val Val Leu Pro Pro 
        435                 440                 445


Ile Val Ala Ser Lys Gly Gln Ser Glu Glu Pro Ala Gly Lys Thr Lys 
    450                 455                 460


Ser Met Gln Glu Val His Met Lys Thr Val Glu Glu Ile Lys Leu Glu 
465                 470                 475                 480


Lys Ala Leu Arg Val Gln Gln Ser Ser Glu Ser Ser Thr Ser Ser Pro 
                485                 490                 495


Ser Gln His Glu Ala Thr Pro Gly Ala Arg Leu Leu Leu Arg Ile Thr 
            500                 505                 510


Lys Arg Thr Trp Arg Lys Glu Glu Lys Lys Leu Gln Glu Gly Asn Glu 
        515                 520                 525


Val Asp Phe Leu Ser Arg Val Arg Met Glu Ala Thr Glu Ala Ser Val 
    530                 535                 540


Glu Thr Thr Gly Val Asp Ile Thr Lys Ile Gln Val Lys Arg Cys Glu 
545                 550                 555                 560


Ile Met Arg Glu Thr Arg Met Gln Lys Gln Gln Glu Arg Glu Lys Ser 
                565                 570                 575


Val Leu Thr Pro Leu Gln Gly Asp Val Ala Ser Cys Asn Thr Gln Val 
            580                 585                 590


Ala Glu Lys Pro Val Leu Thr Ala Val Pro Gly Ile Thr Trp His Leu 
        595                 600                 605


Thr Lys Gln Leu Pro Thr Lys Ser Ser Gln Lys Val Glu Val Glu Thr 
    610                 615                 620


Ser Gly Ile Ala Asp Ser Leu Leu Asn Val Lys Trp Ser Ala Gln Thr 
625                 630                 635                 640


Leu Glu Lys Arg Gly Glu Ala Lys Pro Thr Val Asn Val Lys Gln Ser 
                645                 650                 655


Val Val Lys Val Val Ser Ser Pro Lys Leu Ala Pro Lys Arg Lys Ala 
            660                 665                 670


Val Glu Met His Pro Ala Val Thr Ala Ala Val Lys Pro Leu Ser Ser 
        675                 680                 685


Ser Ser Val Leu Gln Glu Pro Pro Ala Lys Lys Ala Ala Val Asp Ala 
    690                 695                 700


Val Val Leu Leu Val Ser Glu Asp Lys Ser Val Thr Val Pro Glu Thr 
705                 710                 715                 720


Glu Asn Pro Arg Asp Ser Leu Val Leu Pro Leu Thr Gln Ser Ser Ser 
                725                 730                 735


Asp Ser Ser Pro Pro Glu Val Ser Gly Pro Ser Ser Ser Gln Met Ser 
            740                 745                 750


Met Lys Thr Arg Arg Leu Ser Ser Ala Ser Thr Gly Lys Pro Pro Leu 
        755                 760                 765


Ser Val Glu Asp Asp Phe Glu Lys Leu Thr Trp Glu Ile Ser Gly Gly 
    770                 775                 780


Lys Leu Glu Ala Glu Ile Asp Leu Asp Pro Gly Lys Asp Glu Asp Asp 
785                 790                 795                 800


Leu Pro Leu Glu Leu 
                805


<210>  3258
<211>  2032
<212>  DNA
<213>  Homo sapiens

<400>  3258
accggccggg ccttagagcg cagcctgtag ccgggcgcca tctttgacgc tggcagtctt     60

ggttttctgc tagtgctgct gctgctggga ggacgacgga cggcagcggc caagcgagaa    120

gaaagacgtg gcagcaagcg ggagtcgggg atagtgtcat cggttcgggt cccactactt    180

tggagcttgt ctcaaactcc acatacagaa agccaccgac cttattccga ttatattgtt    240

cagctatgga agatggattt tttttcatga tcctttgact ctcaagttca tctttaaatg    300

aactcttttt tttgttttgt ttttgaggag ataactaacc ctagctgtct ccagtctgac    360

aaaggttatt tgaatggact taatctccca gtagttggga gatgttttaa aaacacatgc    420

tgtgtttgaa ttgtggctga gaggttttct tggcaatgtg aggaggaaaa ttttttctgc    480

ttcattatta ttaattcatg gattgagtgt tggttcgacc tacaggcgta atagattgga    540

actcagtgaa gacacagacg ttcctgttga gagcaatcag ctaatgatta cagtttaaag    600

acaatttctg tgatcaagtt gtcatttgga agattaaacc catttcacga ggacttggag    660

cctggtcctt gctttgagga agcagtggct tgtttcaaga agccacttct gatctaagaa    720

tctacccagc atgcctaatc aaggagaaga ctgctatttt tttttctatt ctacatgtac    780

caaaggtgac agctgcccat tccgtcactg tgaagctgca ctaggcaatg aaactgtttg    840

cacattatgg caagaagggc gctgttttcg acgggtgtgc aggtttcggc acatggagat    900

tgataaaaaa cgcagtgaaa ttccttgtta ttgggaaaat cagccaacag gatgtcaaaa    960

attaaactgc gctttccatc acaatagagg acgatatgtt gatggccttt tcctacctcc   1020

gagcaaaagt gtgttgccca ctgtgcctga gtcaccagaa gaggaagtga aggctagcca   1080

actttcagtt cagcagaaca aattgtctgt ccagtccaat ccttcccctc agctgcggag   1140

cgttatgaaa gtagaaagtt ccgaaaatgt tcctagcccc aagcatccac cagttgtaat   1200

taatgctgca gatgatgatg aagatgatga tgatcagttt tctgaggaag gtgatgaaac   1260

caaaacacct accctgcaac caactcctga agttcacaat ggattacgag tgacttctgt   1320

ccggaaacct gcagtcaata taaagcaagg tgaatgtttg cattttggaa taaaaactct   1380

tgaggaaatt aagtcaaaga aaatgaagga aaaatctgag gagcaaggtg agggttcttc   1440

aggagtttcc agtcttttac tccaccctga gcctgttcca ggtcctgaaa aagaaaatgt   1500

caggactgtg gtgaggacag taactctctc caccaaacaa ggagaagaac ccttggttag   1560

attgggcctt actgagacac tggggaaacg aaaattttcg acaggcggtg acagtgatcc   1620

tccattaaag cgcagcctgg cacagaggct agggaagaaa gttgaagctc cagaaactaa   1680

cactgacgaa acaccaaaga aagctcaagt ttccaagtct cttaaggagc gattaggcat   1740

gtcagctgat ccaaataatg aggacgcaac agataaagtt aataaagttg gtgagatcca   1800

tgtgaagaca ttagaagaaa tgcttcttga aagagccagt cagaaacatg gggaatcgca   1860

aactaaactc aagacagaag gaccttcaaa aactgatgat tctacttcag gagcaagaag   1920

ctcctccact atccgtatca aaaccttctc tgaggtcctg gctgaagaag aacataggca   1980

gcaggaagca gagagacaaa aaagcaaaaa ggatacaact tgcatcaagc ta           2032


<210>  3259
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  3259

Met Pro Asn Gln Gly Glu Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys 
1               5                   10                  15


Thr Lys Gly Asp Ser Cys Pro Phe Arg His Cys Glu Ala Ala Leu Gly 
            20                  25                  30


Asn Glu Thr Val Cys Thr Leu Trp Gln Glu Gly Arg Cys Phe Arg Arg 
        35                  40                  45


Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile 
    50                  55                  60


Pro Cys Tyr Trp Glu Asn Gln Pro Thr Gly Cys Gln Lys Leu Asn Cys 
65                  70                  75                  80


Ala Phe His His Asn Arg Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro 
                85                  90                  95


Pro Ser Lys Ser Val Leu Pro Thr Val Pro Glu Ser Pro Glu Glu Glu 
            100                 105                 110


Val Lys Ala Ser Gln Leu Ser Val Gln Gln Asn Lys Leu Ser Val Gln 
        115                 120                 125


Ser Asn Pro Ser Pro Gln Leu Arg Ser Val Met Lys Val Glu Ser Ser 
    130                 135                 140


Glu Asn Val Pro Ser Pro Lys His Pro Pro Val Val Ile Asn Ala Ala 
145                 150                 155                 160


Asp Asp Asp Glu Asp Asp Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu 
                165                 170                 175


Thr Lys Thr Pro Thr Leu Gln Pro Thr Pro Glu Val His Asn Gly Leu 
            180                 185                 190


Arg Val Thr Ser Val Arg Lys Pro Ala Val Asn Ile Lys Gln Gly Glu 
        195                 200                 205


Cys Leu His Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys 
    210                 215                 220


Met Lys Glu Lys Ser Glu Glu Gln Gly Glu Gly Ser Ser Gly Val Ser 
225                 230                 235                 240


Ser Leu Leu Leu His Pro Glu Pro Val Pro Gly Pro Glu Lys Glu Asn 
                245                 250                 255


Val Arg Thr Val Val Arg Thr Val Thr Leu Ser Thr Lys Gln Gly Glu 
            260                 265                 270


Glu Pro Leu Val Arg Leu Gly Leu Thr Glu Thr Leu Gly Lys Arg Lys 
        275                 280                 285


Phe Ser Thr Gly Gly Asp Ser Asp Pro Pro Leu Lys Arg Ser Leu Ala 
    290                 295                 300


Gln Arg Leu Gly Lys Lys Val Glu Ala Pro Glu Thr Asn Thr Asp Glu 
305                 310                 315                 320


Thr Pro Lys Lys Ala Gln Val Ser Lys Ser Leu Lys Glu Arg Leu Gly 
                325                 330                 335


Met Ser Ala Asp Pro Asn Asn Glu Asp Ala Thr Asp Lys Val Asn Lys 
            340                 345                 350


Val Gly Glu Ile His Val Lys Thr Leu Glu Glu Met Leu Leu Glu Arg 
        355                 360                 365


Ala Ser Gln Lys His Gly Glu Ser Gln Thr Lys Leu Lys Thr Glu Gly 
    370                 375                 380


Pro Ser Lys Thr Asp Asp Ser Thr Ser Gly Ala Arg Ser Ser Ser Thr 
385                 390                 395                 400


Ile Arg Ile Lys Thr Phe Ser Glu Val Leu Ala Glu Glu Glu His Arg 
                405                 410                 415


Gln Gln Glu Ala Glu Arg Gln Lys Ser Lys Lys Asp Thr Thr Cys Ile 
            420                 425                 430


Lys 



<210>  3260
<211>  4763
<212>  DNA
<213>  Homo sapiens

<400>  3260
cggccgggcc ttagagcgca gcctgtagcc gggcgccatc tttgacgctg gcagtcttgg     60

ttttctgcta gtgctgctgc tgctgggagg acgacggacg gcagcggcca agcgagaaga    120

aagacgtggc agcaagcggg agtcggggat agtgtcatcg gttcgggtcc cactactttg    180

gagcttgtct caaactccac atacagaaag ccaccgacct tattccggta tcctacaccc    240

attccccacc ctcattacac tcccacccct ggccctcagc gtgggagtca agagcaacag    300

ggacacttcc gtactccttg taggattggt gaaaccgtaa tgacgaacac ccctaaactc    360

ccataattgg atttggggat attccctgcc caaaaaattc ctggaaaatt gactagtatt    420

aagtgcgtaa tagattggaa ctcagtgaag acacagacgt tcctgttgag agcaatcagc    480

taatgattac agtttaaaga caatttctgt gatcaagttg tcatttggaa gattaaaccc    540

atttcacgag gacttggagc ctggtccttg ctttgaggaa gcagtggctt gtttcaagaa    600

gccacttctg atctaagaat ctacccagca tgcctaatca aggagaagac tgctattttt    660

ttttctattc tacatgtacc aaaggtgaca gctgcccatt ccgtcactgt gaagctgcac    720

taggcaatga aactgtttgc acattatggc aagaagggcg ctgttttcga cgggtgtgca    780

ggtttcggca catggagatt gataaaaaac gcagtgaaat tccttgttat tgggaaaatc    840

agccaacagg atgtcaaaaa ttaaactgcg ctttccatca caatagagga cgatatgttg    900

atggcctttt cctacctccg agcaaaagtg tgttgcccac tgtgcctgag tcaccagaag    960

aggaagtgaa ggctagccaa ctttcagttc agcagaacaa attgtctgtc cagtccaatc   1020

cttcccctca gctgcggagc gttatgaaag tagaaagttc cgaaaatgtt cctagcccca   1080

agcatccacc agttgtaatt aatgctgcag atgatgatga agatgatgat gatcagtttt   1140

ctgaggaagg tgatgaaacc aaaacaccta ccctgcaacc aactcctgaa gttcacaatg   1200

gattacgagt gacttctgtc cggaaacctg cagtcaatat aaagcaaggt gaatgtttgc   1260

attttggaat aaaaactctt gaggaaatta agtcaaagaa aatgaaggaa aaatctgagg   1320

agcaaggtga gggttcttca ggagtttcca gtcttttact ccaccctgag cctgttccag   1380

gtcctgaaaa agaaaatgtc aggactgtgg tgaggacagt aactctctcc accaaacaag   1440

gagaagaacc cttggttaga ttgggcctta ctgagacact ggggaaacga aaattttcga   1500

caggcggtga cagtgatcct ccattaaagc gcagcctggc acagaggcta gggaagaaag   1560

ttgaagctcc agaaactaac actgacgaaa caccaaagaa agctcaagtt tccaagtctc   1620

ttaaggagcg attaggcatg tcagctgatc caaataatga ggacgcaaca gataaagtta   1680

ataaagttgg tgagatccat gtgaagacat tagaagaaat gcttcttgaa agagccagtc   1740

agaaacatgg ggaatcgcaa actaaactca agacagaagg accttcaaaa actgatgatt   1800

ctacttcagg agcaagaagc tcctccacta tccgtatcaa aaccttctct gaggtcctgg   1860

ctgaagaaga acataggcag caggaagcag agagacaaaa aagcaaaaag gatacaactt   1920

gcatcaagct aaagactgat agtgaaatta aaaaaacagt agttttgcca cccattgttg   1980

ccagcaaagg acaatcagag gagcctgcag gtaaaacaaa gtccatgcag gaggtgcaca   2040

tgaagacggt ggaagaaatt aaactggaga aggcactgag ggtgcagcag agctctgaga   2100

gcagcaccag ctccccgtct caacatgagg ccactccagg ggcaaggttg ctactgcgaa   2160

tcaccaaaag aacatggagg aaagaagaga agaaacttca ggaaggaaat gaagttgatt   2220

ttctgagccg tgttagaatg gaagctacag aggcttcagt tgagaccaca ggagttgaca   2280

tcactaaaat tcaagtcaag agatgtgaga tcatgagaga gacgcgcatg cagaaacagc   2340

aggagaggga aaaatcagtc ttgacacctc ttcagggaga tgtagcctct tgcaataccc   2400

aagtggcaga gaaaccagtg ctcactgctg tgccaggaat cacatggcac ctgaccaagc   2460

agcttcccac aaagtcatcc cagaaggtgg aggtagaaac ctcagggatt gcagactcat   2520

tattgaatgt gaaatggtca gcacagacct tggaaaaaag gggtgaagct aaacccacag   2580

tgaacgtgaa gcaatctgtg gttaaagttg tgtcatcccc caaattggcc ccaaaacgta   2640

aggcagtgga gatgcaccct gctgtcactg ccgctgtgaa gccactcagc tccagcagcg   2700

tcctacagga acccccagcc aaaaaggcag ctgtggatgc tgttgtcctg cttgtctctg   2760

aggacaaatc agtcactgtg cctgaaacag aaaatcctag agacagtctt gtgctgcctc   2820

taacccagtc ctcttcagat tcctcacccc cggaggtgtc tggcccttcc tcatcccaaa   2880

tgagcatgaa aactcgccga ctcagctctg cctcaacagg aaagccccca ctctctgtgg   2940

aggatgattt tgagaaacta acatgggaga tttcaggagg caaattggaa gctgagattg   3000

acctggatcc tgggaaagat gaagatgacc ttccgcttga gctatgagaa atgattgata   3060

gctgaaggtg gtagtgagga cactttaaaa aaaaatcgcc aaaaaactgg acttagtttc   3120

atctattgta acatttacct gagatgatca tttctttagt ctagaatttg ccccaaatca   3180

gaagtatacc tctgaattat ctgtatgtgt cctggattcc ttggggtcag atttttaaag   3240

ttactttata accattttgt ccatttgatg ccattgttta tcatcttttg agaaaaaagt   3300

tctgtcatac ccttctctcc acaaaaaaga gactgagagg gagatcaagt gaaagggtgc   3360

aagcaaactt agtgactcct tgaggtgttt gtcagttttg gcttttttct cctttgttgt   3420

attctttatg tattgtcttg atgtacttaa tattacctga gtttgaaatg gatgaagaca   3480

gctgctacca ttaaggacca aattttatgc taccactaaa caaaaatacc cactcagtct   3540

gtgttagatt gtatgtcttt ttaaaggtat ttagagattc aactaagctt taaagagggc   3600

tgagcagctc aggaagcctg taatgtgggc ataactcttt ggacctgatc ttgatgcttc   3660

tgctgctctg ttggcctctg aagagcaata tctaatttat tattactgta attttttaaa   3720

aggctttaaa gtgcctcagg ggtcccctga aactaatttt ctatttctgg gattccctgg   3780

attcattata tgagatggtg acatgattag aggaattctt ttttagtatg aaaattgtcc   3840

cttttcttct tcagtacttg cctccttgct ggcattgaat taacacaggg acaaaatatg   3900

gttaattttt tatttctaat tctcccaaca aacccctgtt gcccagtatt tatgtggtgg   3960

cctttaacca cctgagggaa aaaatgagct tattcaagct gccaatattt atctatgggc   4020

tgtagcagta cactgaattg tactgtgcca gggatattga gatgctctgg gggtatattg   4080

tatacctgcc agttttcttc atttctgaat tgagttttct tttcttgatg ttggtttcct   4140

tcatatcacc tcaaggttta gatttgtgaa ggaataagca tgatggaaat aatagtcttg   4200

aaaggagata tgttgtatat aatcaggagg aagaggaagg aaggacttac ccattttgat   4260

attttgctgt aggtggccag ttttgtttct catagggaaa tctgaccccc acctgtcatg   4320

ttggctccta aggaactgct gttgtaagcg gctcatcaag agttgaactt cacgtagcct   4380

tgttgggaat atggaaaagg aagaaagcca caggactgcc cattcagtct tgttaagatt   4440

gggatgattc tgcacaagca aaaatgactt gaaatttatg tatcgacaca cctctaccaa   4500

tccatcttca gctgactgaa tgttgtatga tagcccttct ccaaagcagg ggtagaatgt   4560

tcaggtttca ccacggattt tctacttatt tcgcttttgg aatcagctta cagattccag   4620

gtcccttttg tagatattct ttattctttt gcttttttaa aaaataaact ggtattagtc   4680

aatgtttcgt gttccgcatt atttgaacca tttgccctta cagaaagaga aatacttgtt   4740

tgtgttttaa ataaaactga tgt                                           4763


<210>  3261
<211>  805
<212>  PRT
<213>  Homo sapiens

<400>  3261

Met Pro Asn Gln Gly Glu Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys 
1               5                   10                  15


Thr Lys Gly Asp Ser Cys Pro Phe Arg His Cys Glu Ala Ala Leu Gly 
            20                  25                  30


Asn Glu Thr Val Cys Thr Leu Trp Gln Glu Gly Arg Cys Phe Arg Arg 
        35                  40                  45


Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile 
    50                  55                  60


Pro Cys Tyr Trp Glu Asn Gln Pro Thr Gly Cys Gln Lys Leu Asn Cys 
65                  70                  75                  80


Ala Phe His His Asn Arg Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro 
                85                  90                  95


Pro Ser Lys Ser Val Leu Pro Thr Val Pro Glu Ser Pro Glu Glu Glu 
            100                 105                 110


Val Lys Ala Ser Gln Leu Ser Val Gln Gln Asn Lys Leu Ser Val Gln 
        115                 120                 125


Ser Asn Pro Ser Pro Gln Leu Arg Ser Val Met Lys Val Glu Ser Ser 
    130                 135                 140


Glu Asn Val Pro Ser Pro Lys His Pro Pro Val Val Ile Asn Ala Ala 
145                 150                 155                 160


Asp Asp Asp Glu Asp Asp Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu 
                165                 170                 175


Thr Lys Thr Pro Thr Leu Gln Pro Thr Pro Glu Val His Asn Gly Leu 
            180                 185                 190


Arg Val Thr Ser Val Arg Lys Pro Ala Val Asn Ile Lys Gln Gly Glu 
        195                 200                 205


Cys Leu His Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys 
    210                 215                 220


Met Lys Glu Lys Ser Glu Glu Gln Gly Glu Gly Ser Ser Gly Val Ser 
225                 230                 235                 240


Ser Leu Leu Leu His Pro Glu Pro Val Pro Gly Pro Glu Lys Glu Asn 
                245                 250                 255


Val Arg Thr Val Val Arg Thr Val Thr Leu Ser Thr Lys Gln Gly Glu 
            260                 265                 270


Glu Pro Leu Val Arg Leu Gly Leu Thr Glu Thr Leu Gly Lys Arg Lys 
        275                 280                 285


Phe Ser Thr Gly Gly Asp Ser Asp Pro Pro Leu Lys Arg Ser Leu Ala 
    290                 295                 300


Gln Arg Leu Gly Lys Lys Val Glu Ala Pro Glu Thr Asn Thr Asp Glu 
305                 310                 315                 320


Thr Pro Lys Lys Ala Gln Val Ser Lys Ser Leu Lys Glu Arg Leu Gly 
                325                 330                 335


Met Ser Ala Asp Pro Asn Asn Glu Asp Ala Thr Asp Lys Val Asn Lys 
            340                 345                 350


Val Gly Glu Ile His Val Lys Thr Leu Glu Glu Met Leu Leu Glu Arg 
        355                 360                 365


Ala Ser Gln Lys His Gly Glu Ser Gln Thr Lys Leu Lys Thr Glu Gly 
    370                 375                 380


Pro Ser Lys Thr Asp Asp Ser Thr Ser Gly Ala Arg Ser Ser Ser Thr 
385                 390                 395                 400


Ile Arg Ile Lys Thr Phe Ser Glu Val Leu Ala Glu Glu Glu His Arg 
                405                 410                 415


Gln Gln Glu Ala Glu Arg Gln Lys Ser Lys Lys Asp Thr Thr Cys Ile 
            420                 425                 430


Lys Leu Lys Thr Asp Ser Glu Ile Lys Lys Thr Val Val Leu Pro Pro 
        435                 440                 445


Ile Val Ala Ser Lys Gly Gln Ser Glu Glu Pro Ala Gly Lys Thr Lys 
    450                 455                 460


Ser Met Gln Glu Val His Met Lys Thr Val Glu Glu Ile Lys Leu Glu 
465                 470                 475                 480


Lys Ala Leu Arg Val Gln Gln Ser Ser Glu Ser Ser Thr Ser Ser Pro 
                485                 490                 495


Ser Gln His Glu Ala Thr Pro Gly Ala Arg Leu Leu Leu Arg Ile Thr 
            500                 505                 510


Lys Arg Thr Trp Arg Lys Glu Glu Lys Lys Leu Gln Glu Gly Asn Glu 
        515                 520                 525


Val Asp Phe Leu Ser Arg Val Arg Met Glu Ala Thr Glu Ala Ser Val 
    530                 535                 540


Glu Thr Thr Gly Val Asp Ile Thr Lys Ile Gln Val Lys Arg Cys Glu 
545                 550                 555                 560


Ile Met Arg Glu Thr Arg Met Gln Lys Gln Gln Glu Arg Glu Lys Ser 
                565                 570                 575


Val Leu Thr Pro Leu Gln Gly Asp Val Ala Ser Cys Asn Thr Gln Val 
            580                 585                 590


Ala Glu Lys Pro Val Leu Thr Ala Val Pro Gly Ile Thr Trp His Leu 
        595                 600                 605


Thr Lys Gln Leu Pro Thr Lys Ser Ser Gln Lys Val Glu Val Glu Thr 
    610                 615                 620


Ser Gly Ile Ala Asp Ser Leu Leu Asn Val Lys Trp Ser Ala Gln Thr 
625                 630                 635                 640


Leu Glu Lys Arg Gly Glu Ala Lys Pro Thr Val Asn Val Lys Gln Ser 
                645                 650                 655


Val Val Lys Val Val Ser Ser Pro Lys Leu Ala Pro Lys Arg Lys Ala 
            660                 665                 670


Val Glu Met His Pro Ala Val Thr Ala Ala Val Lys Pro Leu Ser Ser 
        675                 680                 685


Ser Ser Val Leu Gln Glu Pro Pro Ala Lys Lys Ala Ala Val Asp Ala 
    690                 695                 700


Val Val Leu Leu Val Ser Glu Asp Lys Ser Val Thr Val Pro Glu Thr 
705                 710                 715                 720


Glu Asn Pro Arg Asp Ser Leu Val Leu Pro Leu Thr Gln Ser Ser Ser 
                725                 730                 735


Asp Ser Ser Pro Pro Glu Val Ser Gly Pro Ser Ser Ser Gln Met Ser 
            740                 745                 750


Met Lys Thr Arg Arg Leu Ser Ser Ala Ser Thr Gly Lys Pro Pro Leu 
        755                 760                 765


Ser Val Glu Asp Asp Phe Glu Lys Leu Thr Trp Glu Ile Ser Gly Gly 
    770                 775                 780


Lys Leu Glu Ala Glu Ile Asp Leu Asp Pro Gly Lys Asp Glu Asp Asp 
785                 790                 795                 800


Leu Pro Leu Glu Leu 
                805


<210>  3262
<211>  5045
<212>  DNA
<213>  Homo sapiens

<400>  3262
cggccgggcc ttagagcgca gcctgtagcc gggcgccatc tttgacgctg gcagtcttgg     60

ttttctgcta gtgctgctgc tgctgggagg acgacggacg gcagcggcca agcgagaaga    120

aagacgtggc agcaagcggg agtcggggat agtgtcatcg gttcgggtcc cactactttg    180

gagcttgtct caaactccac atacagaaag ccaccgacct tattccggta tcctacaccc    240

attccccacc ctcattacac tcccacccct ggccctcagc gtgggagtca agagcaacag    300

ggacacttcc gtactccttg taggattggt gaaaccgtaa tgacgaacac ccctaaactc    360

ccataattgg atttggggat attccctgcc caaaaaattc ctggaaaatt gactagtatt    420

aagtctatgg aagatggatt ttttttcatg atcctttgac tctcaagttc atctttaaat    480

gaactctttt ttttgttttg tttttgagga gataactaac cctagctgtc tccagtctga    540

caaaggttat ttgaatggac ttaatctccc agtagttggg agatgtttta aaaacacatg    600

ctgtgtttga attgtggctg agaggttttc ttggcaatgt gaggaggaaa attttttctg    660

cttcattatt attaattcat ggattgagtg ttggttcgac ctacaggcgt aatagattgg    720

aactcagtga agacacagac gttcctgttg agagcaatca gctaatgatt acagtttaaa    780

gacaatttct gtgatcaagt tgtcatttgg aagattaaac ccatttcacg aggacttgga    840

gcctggtcct tgctttgagg aagcagtggc ttgtttcaag aagccacttc tgatctaaga    900

atctacccag catgcctaat caaggagaag actgctattt ttttttctat tctacatgta    960

ccaaaggtga cagctgccca ttccgtcact gtgaagctgc actaggcaat gaaactgttt   1020

gcacattatg gcaagaaggg cgctgttttc gacgggtgtg caggtttcgg cacatggaga   1080

ttgataaaaa acgcagtgaa attccttgtt attgggaaaa tcagccaaca ggatgtcaaa   1140

aattaaactg cgctttccat cacaatagag gacgatatgt tgatggcctt ttcctacctc   1200

cgagcaaaag tgtgttgccc actgtgcctg agtcaccaga agaggaagtg aaggctagcc   1260

aactttcagt tcagcagaac aaattgtctg tccagtccaa tccttcccct cagctgcgga   1320

gcgttatgaa agtagaaagt tccgaaaatg ttcctagccc caagcatcca ccagttgtaa   1380

ttaatgctgc agatgatgat gaagatgatg atgatcagtt ttctgaggaa ggtgatgaaa   1440

ccaaaacacc taccctgcaa ccaactcctg aagttcacaa tggattacga gtgacttctg   1500

tccggaaacc tgcagtcaat ataaagcaag gtgaatgttt gcattttgga ataaaaactc   1560

ttgaggaaat taagtcaaag aaaatgaagg aaaaatctga ggagcaaggt gagggttctt   1620

caggagtttc cagtctttta ctccaccctg agcctgttcc aggtcctgaa aaagaaaatg   1680

tcaggactgt ggtgaggaca gtaactctct ccaccaaaca aggagaagaa cccttggtta   1740

gattgggcct tactgagaca ctggggaaac gaaaattttc gacaggcggt gacagtgatc   1800

ctccattaaa gcgcagcctg gcacagaggc tagggaagaa agttgaagct ccagaaacta   1860

acactgacga aacaccaaag aaagctcaag tttccaagtc tcttaaggag cgattaggca   1920

tgtcagctga tccaaataat gaggacgcaa cagataaagt taataaagtt ggtgagatcc   1980

atgtgaagac attagaagaa atgcttcttg aaagagccag tcagaaacat ggggaatcgc   2040

aaactaaact caagacagaa ggaccttcaa aaactgatga ttctacttca ggagcaagaa   2100

gctcctccac tatccgtatc aaaaccttct ctgaggtcct ggctgaagaa gaacataggc   2160

agcaggaagc agagagacaa aaaagcaaaa aggatacaac ttgcatcaag ctaaagactg   2220

atagtgaaat taaaaaaaca gtagttttgc cacccattgt tgccagcaaa ggacaatcag   2280

aggagcctgc aggtaaaaca aagtccatgc aggaggtgca catgaagacg gtggaagaaa   2340

ttaaactgga gaaggcactg agggtgcagc agagctctga gagcagcacc agctccccgt   2400

ctcaacatga ggccactcca ggggcaaggt tgctactgcg aatcaccaaa agaacatgga   2460

ggaaagaaga gaagaaactt caggaaggaa atgaagttga ttttctgagc cgtgttagaa   2520

tggaagctac agaggcttca gttgagacca caggagttga catcactaaa attcaagtca   2580

agagatgtga gatcatgaga gagacgcgca tgcagaaaca gcaggagagg gaaaaatcag   2640

tcttgacacc tcttcaggga gatgtagcct cttgcaatac ccaagtggca gagaaaccag   2700

tgctcactgc tgtgccagga atcacatggc acctgaccaa gcagcttccc acaaagtcat   2760

cccagaaggt ggaggtagaa acctcaggga ttgcagactc attattgaat gtgaaatggt   2820

cagcacagac cttggaaaaa aggggtgaag ctaaacccac agtgaacgtg aagcaatctg   2880

tggttaaagt tgtgtcatcc cccaaattgg ccccaaaacg taaggcagtg gagatgcacc   2940

ctgctgtcac tgccgctgtg aagccactca gctccagcag cgtcctacag gaacccccag   3000

ccaaaaaggc agctgtggat gctgttgtcc tgcttgtctc tgaggacaaa tcagtcactg   3060

tgcctgaaac agaaaatcct agagacagtc ttgtgctgcc tctaacccag tcctcttcag   3120

attcctcacc cccggaggtg tctggccctt cctcatccca aatgagcatg aaaactcgcc   3180

gactcagctc tgcctcaaca ggaaagcccc cactctctgt ggaggatgat tttgagaaac   3240

taacatggga gatttcagga ggcaaattgg aagctgagat tgacctggat cctgggaaag   3300

atgaagatga ccttccgctt gagctatgag aaatgattga tagctgaagg tggtagtgag   3360

gacactttaa aaaaaaatcg ccaaaaaact ggacttagtt tcatctattg taacatttac   3420

ctgagatgat catttcttta gtctagaatt tgccccaaat cagaagtata cctctgaatt   3480

atctgtatgt gtcctggatt ccttggggtc agatttttaa agttacttta taaccatttt   3540

gtccatttga tgccattgtt tatcatcttt tgagaaaaaa gttctgtcat acccttctct   3600

ccacaaaaaa gagactgaga gggagatcaa gtgaaagggt gcaagcaaac ttagtgactc   3660

cttgaggtgt ttgtcagttt tggctttttt ctcctttgtt gtattcttta tgtattgtct   3720

tgatgtactt aatattacct gagtttgaaa tggatgaaga cagctgctac cattaaggac   3780

caaattttat gctaccacta aacaaaaata cccactcagt ctgtgttaga ttgtatgtct   3840

ttttaaaggt atttagagat tcaactaagc tttaaagagg gctgagcagc tcaggaagcc   3900

tgtaatgtgg gcataactct ttggacctga tcttgatgct tctgctgctc tgttggcctc   3960

tgaagagcaa tatctaattt attattactg taatttttta aaaggcttta aagtgcctca   4020

ggggtcccct gaaactaatt ttctatttct gggattccct ggattcatta tatgagatgg   4080

tgacatgatt agaggaattc ttttttagta tgaaaattgt cccttttctt cttcagtact   4140

tgcctccttg ctggcattga attaacacag ggacaaaata tggttaattt tttatttcta   4200

attctcccaa caaacccctg ttgcccagta tttatgtggt ggcctttaac cacctgaggg   4260

aaaaaatgag cttattcaag ctgccaatat ttatctatgg gctgtagcag tacactgaat   4320

tgtactgtgc cagggatatt gagatgctct gggggtatat tgtatacctg ccagttttct   4380

tcatttctga attgagtttt cttttcttga tgttggtttc cttcatatca cctcaaggtt   4440

tagatttgtg aaggaataag catgatggaa ataatagtct tgaaaggaga tatgttgtat   4500

ataatcagga ggaagaggaa ggaaggactt acccattttg atattttgct gtaggtggcc   4560

agttttgttt ctcataggga aatctgaccc ccacctgtca tgttggctcc taaggaactg   4620

ctgttgtaag cggctcatca agagttgaac ttcacgtagc cttgttggga atatggaaaa   4680

ggaagaaagc cacaggactg cccattcagt cttgttaaga ttgggatgat tctgcacaag   4740

caaaaatgac ttgaaattta tgtatcgaca cacctctacc aatccatctt cagctgactg   4800

aatgttgtat gatagccctt ctccaaagca ggggtagaat gttcaggttt caccacggat   4860

tttctactta tttcgctttt ggaatcagct tacagattcc aggtcccttt tgtagatatt   4920

ctttattctt ttgctttttt aaaaaataaa ctggtattag tcaatgtttc gtgttccgca   4980

ttatttgaac catttgccct tacagaaaga gaaatacttg tttgtgtttt aaataaaact   5040

gatgt                                                               5045


<210>  3263
<211>  805
<212>  PRT
<213>  Homo sapiens

<400>  3263

Met Pro Asn Gln Gly Glu Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys 
1               5                   10                  15


Thr Lys Gly Asp Ser Cys Pro Phe Arg His Cys Glu Ala Ala Leu Gly 
            20                  25                  30


Asn Glu Thr Val Cys Thr Leu Trp Gln Glu Gly Arg Cys Phe Arg Arg 
        35                  40                  45


Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile 
    50                  55                  60


Pro Cys Tyr Trp Glu Asn Gln Pro Thr Gly Cys Gln Lys Leu Asn Cys 
65                  70                  75                  80


Ala Phe His His Asn Arg Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro 
                85                  90                  95


Pro Ser Lys Ser Val Leu Pro Thr Val Pro Glu Ser Pro Glu Glu Glu 
            100                 105                 110


Val Lys Ala Ser Gln Leu Ser Val Gln Gln Asn Lys Leu Ser Val Gln 
        115                 120                 125


Ser Asn Pro Ser Pro Gln Leu Arg Ser Val Met Lys Val Glu Ser Ser 
    130                 135                 140


Glu Asn Val Pro Ser Pro Lys His Pro Pro Val Val Ile Asn Ala Ala 
145                 150                 155                 160


Asp Asp Asp Glu Asp Asp Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu 
                165                 170                 175


Thr Lys Thr Pro Thr Leu Gln Pro Thr Pro Glu Val His Asn Gly Leu 
            180                 185                 190


Arg Val Thr Ser Val Arg Lys Pro Ala Val Asn Ile Lys Gln Gly Glu 
        195                 200                 205


Cys Leu His Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys 
    210                 215                 220


Met Lys Glu Lys Ser Glu Glu Gln Gly Glu Gly Ser Ser Gly Val Ser 
225                 230                 235                 240


Ser Leu Leu Leu His Pro Glu Pro Val Pro Gly Pro Glu Lys Glu Asn 
                245                 250                 255


Val Arg Thr Val Val Arg Thr Val Thr Leu Ser Thr Lys Gln Gly Glu 
            260                 265                 270


Glu Pro Leu Val Arg Leu Gly Leu Thr Glu Thr Leu Gly Lys Arg Lys 
        275                 280                 285


Phe Ser Thr Gly Gly Asp Ser Asp Pro Pro Leu Lys Arg Ser Leu Ala 
    290                 295                 300


Gln Arg Leu Gly Lys Lys Val Glu Ala Pro Glu Thr Asn Thr Asp Glu 
305                 310                 315                 320


Thr Pro Lys Lys Ala Gln Val Ser Lys Ser Leu Lys Glu Arg Leu Gly 
                325                 330                 335


Met Ser Ala Asp Pro Asn Asn Glu Asp Ala Thr Asp Lys Val Asn Lys 
            340                 345                 350


Val Gly Glu Ile His Val Lys Thr Leu Glu Glu Met Leu Leu Glu Arg 
        355                 360                 365


Ala Ser Gln Lys His Gly Glu Ser Gln Thr Lys Leu Lys Thr Glu Gly 
    370                 375                 380


Pro Ser Lys Thr Asp Asp Ser Thr Ser Gly Ala Arg Ser Ser Ser Thr 
385                 390                 395                 400


Ile Arg Ile Lys Thr Phe Ser Glu Val Leu Ala Glu Glu Glu His Arg 
                405                 410                 415


Gln Gln Glu Ala Glu Arg Gln Lys Ser Lys Lys Asp Thr Thr Cys Ile 
            420                 425                 430


Lys Leu Lys Thr Asp Ser Glu Ile Lys Lys Thr Val Val Leu Pro Pro 
        435                 440                 445


Ile Val Ala Ser Lys Gly Gln Ser Glu Glu Pro Ala Gly Lys Thr Lys 
    450                 455                 460


Ser Met Gln Glu Val His Met Lys Thr Val Glu Glu Ile Lys Leu Glu 
465                 470                 475                 480


Lys Ala Leu Arg Val Gln Gln Ser Ser Glu Ser Ser Thr Ser Ser Pro 
                485                 490                 495


Ser Gln His Glu Ala Thr Pro Gly Ala Arg Leu Leu Leu Arg Ile Thr 
            500                 505                 510


Lys Arg Thr Trp Arg Lys Glu Glu Lys Lys Leu Gln Glu Gly Asn Glu 
        515                 520                 525


Val Asp Phe Leu Ser Arg Val Arg Met Glu Ala Thr Glu Ala Ser Val 
    530                 535                 540


Glu Thr Thr Gly Val Asp Ile Thr Lys Ile Gln Val Lys Arg Cys Glu 
545                 550                 555                 560


Ile Met Arg Glu Thr Arg Met Gln Lys Gln Gln Glu Arg Glu Lys Ser 
                565                 570                 575


Val Leu Thr Pro Leu Gln Gly Asp Val Ala Ser Cys Asn Thr Gln Val 
            580                 585                 590


Ala Glu Lys Pro Val Leu Thr Ala Val Pro Gly Ile Thr Trp His Leu 
        595                 600                 605


Thr Lys Gln Leu Pro Thr Lys Ser Ser Gln Lys Val Glu Val Glu Thr 
    610                 615                 620


Ser Gly Ile Ala Asp Ser Leu Leu Asn Val Lys Trp Ser Ala Gln Thr 
625                 630                 635                 640


Leu Glu Lys Arg Gly Glu Ala Lys Pro Thr Val Asn Val Lys Gln Ser 
                645                 650                 655


Val Val Lys Val Val Ser Ser Pro Lys Leu Ala Pro Lys Arg Lys Ala 
            660                 665                 670


Val Glu Met His Pro Ala Val Thr Ala Ala Val Lys Pro Leu Ser Ser 
        675                 680                 685


Ser Ser Val Leu Gln Glu Pro Pro Ala Lys Lys Ala Ala Val Asp Ala 
    690                 695                 700


Val Val Leu Leu Val Ser Glu Asp Lys Ser Val Thr Val Pro Glu Thr 
705                 710                 715                 720


Glu Asn Pro Arg Asp Ser Leu Val Leu Pro Leu Thr Gln Ser Ser Ser 
                725                 730                 735


Asp Ser Ser Pro Pro Glu Val Ser Gly Pro Ser Ser Ser Gln Met Ser 
            740                 745                 750


Met Lys Thr Arg Arg Leu Ser Ser Ala Ser Thr Gly Lys Pro Pro Leu 
        755                 760                 765


Ser Val Glu Asp Asp Phe Glu Lys Leu Thr Trp Glu Ile Ser Gly Gly 
    770                 775                 780


Lys Leu Glu Ala Glu Ile Asp Leu Asp Pro Gly Lys Asp Glu Asp Asp 
785                 790                 795                 800


Leu Pro Leu Glu Leu 
                805


<210>  3264
<211>  1614
<212>  DNA
<213>  Homo sapiens

<400>  3264
gtcttggttt tctgctagtg ctgctgctgc tgggaggacg acggacggca gcggccaagc     60

gagaagaaag acgtggcagc aagcgggagt cggggatagt gtcatcggcg taatagattg    120

gaactcagtg aagacacaga cgttcctgtt gagagcaatc agctaatgat tacagtttaa    180

agacaatttc tgtgatcaag ttgtcatttg gaagattaaa cccatttcac gaggacttgg    240

agcctggtcc ttgctttgag gaagcagtgg cttgtttcaa gaagccactt ctgatctaag    300

aatctaccca gcatgcctaa tcaaggagaa gactgctatt tttttttcta ttctacatgt    360

accaaaggtg acagctgccc attccgtcac tgtgaagctg cactaggcaa tgaaactgtt    420

tgcacattat ggcaagaagg gcgctgtttt cgacgggtgt gcaggtttcg gcacatggag    480

attgataaaa aacgcagtga aattccttgt tattgggaaa atcagccaac aggatgtcaa    540

aaattaaact gcgctttcca tcacaataga ggacgatatg ttgatggcct tttcctacct    600

ccgagcaaaa gtgtgttgcc cactgtgcct gagtcaccag aagaggaagt gaaggctagc    660

caactttcag ttcagcagaa caaattgtct gtccagtcca atccttcccc tcagctgcgg    720

agcgttatga aagtagaaag ttccgaaaat gttcctagcc ccaagcatcc accagttgta    780

attaatgctg cagatgatga tgaagatgat gatgatcagt tttctgagga aggtgatgaa    840

accaaaacac ctaccctgca accaactcct gaagttcaca atggattacg agtgacttct    900

gtccggaaac ctgcagtcaa tataaagcaa ggtgaatgtt tgcattttgg aataaaaact    960

cttgaggaaa ttaagtcaaa gaaaatgaag gaaaaatctg aggagcaagg tgagggttct   1020

tcaggagttt ccagtctttt actccaccct gagcctgttc caggtcctga aaaagaaaat   1080

gtcaggactg tggtgaggac agtaactctc tccaccaaac aaggagaaga acccttggtt   1140

agattgggcc ttactgagac actggggaaa cgaaaatttt cgacaggcgg tgacagtgat   1200

cctccattaa agcgcagcct ggcacagagg ctagggaaga aagttgaagc tccagaaact   1260

aacactgacg aaacaccaaa gaaagctcaa gtttccaagt ctcttaagga gcgattaggc   1320

atgtcagctg atccaaataa tgaggacgca acagataaag ttaataaagt tggtgagatc   1380

catgtgaaga cattagaaga aatgcttctt gaaagagcca gtcagaaaca tggggaatcg   1440

caaactaaac tcaagacaga aggaccttca aaaactgatg attctacttc aggagcaaga   1500

agctcctcca ctatccgtat caaaaccttc tctgaggtcc tggctgaaga agaacatagg   1560

cagcaggaag cagagagaca aaaaagcaaa aaggatacaa cttgcatcaa gcta         1614


<210>  3265
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  3265

Met Pro Asn Gln Gly Glu Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys 
1               5                   10                  15


Thr Lys Gly Asp Ser Cys Pro Phe Arg His Cys Glu Ala Ala Leu Gly 
            20                  25                  30


Asn Glu Thr Val Cys Thr Leu Trp Gln Glu Gly Arg Cys Phe Arg Arg 
        35                  40                  45


Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile 
    50                  55                  60


Pro Cys Tyr Trp Glu Asn Gln Pro Thr Gly Cys Gln Lys Leu Asn Cys 
65                  70                  75                  80


Ala Phe His His Asn Arg Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro 
                85                  90                  95


Pro Ser Lys Ser Val Leu Pro Thr Val Pro Glu Ser Pro Glu Glu Glu 
            100                 105                 110


Val Lys Ala Ser Gln Leu Ser Val Gln Gln Asn Lys Leu Ser Val Gln 
        115                 120                 125


Ser Asn Pro Ser Pro Gln Leu Arg Ser Val Met Lys Val Glu Ser Ser 
    130                 135                 140


Glu Asn Val Pro Ser Pro Lys His Pro Pro Val Val Ile Asn Ala Ala 
145                 150                 155                 160


Asp Asp Asp Glu Asp Asp Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu 
                165                 170                 175


Thr Lys Thr Pro Thr Leu Gln Pro Thr Pro Glu Val His Asn Gly Leu 
            180                 185                 190


Arg Val Thr Ser Val Arg Lys Pro Ala Val Asn Ile Lys Gln Gly Glu 
        195                 200                 205


Cys Leu His Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys 
    210                 215                 220


Met Lys Glu Lys Ser Glu Glu Gln Gly Glu Gly Ser Ser Gly Val Ser 
225                 230                 235                 240


Ser Leu Leu Leu His Pro Glu Pro Val Pro Gly Pro Glu Lys Glu Asn 
                245                 250                 255


Val Arg Thr Val Val Arg Thr Val Thr Leu Ser Thr Lys Gln Gly Glu 
            260                 265                 270


Glu Pro Leu Val Arg Leu Gly Leu Thr Glu Thr Leu Gly Lys Arg Lys 
        275                 280                 285


Phe Ser Thr Gly Gly Asp Ser Asp Pro Pro Leu Lys Arg Ser Leu Ala 
    290                 295                 300


Gln Arg Leu Gly Lys Lys Val Glu Ala Pro Glu Thr Asn Thr Asp Glu 
305                 310                 315                 320


Thr Pro Lys Lys Ala Gln Val Ser Lys Ser Leu Lys Glu Arg Leu Gly 
                325                 330                 335


Met Ser Ala Asp Pro Asn Asn Glu Asp Ala Thr Asp Lys Val Asn Lys 
            340                 345                 350


Val Gly Glu Ile His Val Lys Thr Leu Glu Glu Met Leu Leu Glu Arg 
        355                 360                 365


Ala Ser Gln Lys His Gly Glu Ser Gln Thr Lys Leu Lys Thr Glu Gly 
    370                 375                 380


Pro Ser Lys Thr Asp Asp Ser Thr Ser Gly Ala Arg Ser Ser Ser Thr 
385                 390                 395                 400


Ile Arg Ile Lys Thr Phe Ser Glu Val Leu Ala Glu Glu Glu His Arg 
                405                 410                 415


Gln Gln Glu Ala Glu Arg Gln Lys Ser Lys Lys Asp Thr Thr Cys Ile 
            420                 425                 430


Lys 



<210>  3266
<211>  1556
<212>  DNA
<213>  Homo sapiens

<400>  3266
tagtgctgct gctgctggga ggacgacgga cggcagcggc caagcgagaa gaaagacgtg     60

gcagcaagcg ggagtcgggg atagtgtcat cggttcgggt cccactactt tggagagttt    120

aaagacaatt tctgtgatca agttgtcatt tggaagatta aacccatttc acgaggactt    180

ggagcctggt ccttgctttg aggaagcagt ggcttgtttc aagaagccac ttctgatcta    240

agaatctacc cagcatgcct aatcaaggag aagactgcta tttttttttc tattctacat    300

gtaccaaagg tgacagctgc ccattccgtc actgtgaagc tgcactaggc aatgaaactg    360

tttgcacatt atggcaagaa gggcgctgtt ttcgacgggt gtgcaggttt cggcacatgg    420

agattgataa aaaacgcagt gaaattcctt gttattggga aaatcagcca acaggatgtc    480

aaaaattaaa ctgcgctttc catcacaata gaggacgata tgttgatggc cttttcctac    540

ctccgagcaa aagtgtgttg cccactgtgc ctgagtcacc agaagaggaa gtgaaggcta    600

gccaactttc agttcagcag aacaaattgt ctgtccagtc caatccttcc cctcagctgc    660

ggagcgttat gaaagtagaa agttccgaaa atgttcctag ccccaagcat ccaccagttg    720

taattaatgc tgcagatgat gatgaagatg atgatgatca gttttctgag gaaggtgatg    780

aaaccaaaac acctaccctg caaccaactc ctgaagttca caatggatta cgagtgactt    840

ctgtccggaa acctgcagtc aatataaagc aaggtgaatg tttgcatttt ggaataaaaa    900

ctcttgagga aattaagtca aagaaaatga aggaaaaatc tgaggagcaa ggtgagggtt    960

cttcaggagt ttccagtctt ttactccacc ctgagcctgt tccaggtcct gaaaaagaaa   1020

atgtcaggac tgtggtgagg acagtaactc tctccaccaa acaaggagaa gaacccttgg   1080

ttagattggg ccttactgag acactgggga aacgaaaatt ttcgacaggc ggtgacagtg   1140

atcctccatt aaagcgcagc ctggcacaga ggctagggaa gaaagttgaa gctccagaaa   1200

ctaacactga cgaaacacca aagaaagctc aagtttccaa gtctcttaag gagcgattag   1260

gcatgtcagc tgatccaaat aatgaggacg caacagataa agttaataaa gttggtgaga   1320

tccatgtgaa gacattagaa gaaatgcttc ttgaaagagc cagtcagaaa catggggaat   1380

cgcaaactaa actcaagaca gaaggacctt caaaaactga tgattctact tcaggagcaa   1440

gaagctcctc cactatccgt atcaaaacct tctctgaggt cctggctgaa gaagaacata   1500

ggcagcagga agcagagaga caaaaaagca aaaaggatac aacttgcatc aagcta       1556


<210>  3267
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  3267

Met Pro Asn Gln Gly Glu Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys 
1               5                   10                  15


Thr Lys Gly Asp Ser Cys Pro Phe Arg His Cys Glu Ala Ala Leu Gly 
            20                  25                  30


Asn Glu Thr Val Cys Thr Leu Trp Gln Glu Gly Arg Cys Phe Arg Arg 
        35                  40                  45


Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile 
    50                  55                  60


Pro Cys Tyr Trp Glu Asn Gln Pro Thr Gly Cys Gln Lys Leu Asn Cys 
65                  70                  75                  80


Ala Phe His His Asn Arg Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro 
                85                  90                  95


Pro Ser Lys Ser Val Leu Pro Thr Val Pro Glu Ser Pro Glu Glu Glu 
            100                 105                 110


Val Lys Ala Ser Gln Leu Ser Val Gln Gln Asn Lys Leu Ser Val Gln 
        115                 120                 125


Ser Asn Pro Ser Pro Gln Leu Arg Ser Val Met Lys Val Glu Ser Ser 
    130                 135                 140


Glu Asn Val Pro Ser Pro Lys His Pro Pro Val Val Ile Asn Ala Ala 
145                 150                 155                 160


Asp Asp Asp Glu Asp Asp Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu 
                165                 170                 175


Thr Lys Thr Pro Thr Leu Gln Pro Thr Pro Glu Val His Asn Gly Leu 
            180                 185                 190


Arg Val Thr Ser Val Arg Lys Pro Ala Val Asn Ile Lys Gln Gly Glu 
        195                 200                 205


Cys Leu His Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys 
    210                 215                 220


Met Lys Glu Lys Ser Glu Glu Gln Gly Glu Gly Ser Ser Gly Val Ser 
225                 230                 235                 240


Ser Leu Leu Leu His Pro Glu Pro Val Pro Gly Pro Glu Lys Glu Asn 
                245                 250                 255


Val Arg Thr Val Val Arg Thr Val Thr Leu Ser Thr Lys Gln Gly Glu 
            260                 265                 270


Glu Pro Leu Val Arg Leu Gly Leu Thr Glu Thr Leu Gly Lys Arg Lys 
        275                 280                 285


Phe Ser Thr Gly Gly Asp Ser Asp Pro Pro Leu Lys Arg Ser Leu Ala 
    290                 295                 300


Gln Arg Leu Gly Lys Lys Val Glu Ala Pro Glu Thr Asn Thr Asp Glu 
305                 310                 315                 320


Thr Pro Lys Lys Ala Gln Val Ser Lys Ser Leu Lys Glu Arg Leu Gly 
                325                 330                 335


Met Ser Ala Asp Pro Asn Asn Glu Asp Ala Thr Asp Lys Val Asn Lys 
            340                 345                 350


Val Gly Glu Ile His Val Lys Thr Leu Glu Glu Met Leu Leu Glu Arg 
        355                 360                 365


Ala Ser Gln Lys His Gly Glu Ser Gln Thr Lys Leu Lys Thr Glu Gly 
    370                 375                 380


Pro Ser Lys Thr Asp Asp Ser Thr Ser Gly Ala Arg Ser Ser Ser Thr 
385                 390                 395                 400


Ile Arg Ile Lys Thr Phe Ser Glu Val Leu Ala Glu Glu Glu His Arg 
                405                 410                 415


Gln Gln Glu Ala Glu Arg Gln Lys Ser Lys Lys Asp Thr Thr Cys Ile 
            420                 425                 430


Lys 



<210>  3268
<211>  1517
<212>  DNA
<213>  Homo sapiens

<400>  3268
ttatattgtt cagctatgga agatggattt tttttcatga tcctttgact ctcaagttca     60

tctttaaatg aactcttttt tttgttttgt ttttgaggag ataactaacc ctagctgtct    120

ccagtctgac aaaggttatt tgaatggact taatctccca gtagttggga gatgttttaa    180

aaacacatgc tgtgtttgaa ttgtggctga gaggttttct tggcaatgtg aggaggaaaa    240

ttttttctgc ttcattatta ttaattcatg gattgagtgt tggttcgacc tacaggcgta    300

atagattgga actcagtgaa gacacagacg ttcctgttga gagcaatcag ctaatgatta    360

cagtttaaag acaatttctg tgatcaagtt gtcatttgga agattaaacc catttcacga    420

ggacttggag cctggtcctt gctttgagga agcagtggct tgtttcaaga agccacttct    480

gatctaagaa tctacccagc atgcctaatc aaggagaaga ctgctatttt tttttctatt    540

ctacatgtac caaaggtgac agctgcccat tccgtcactg tgaagctgca ctaggcaatg    600

aaactgtttg cacattatgg caagaagggc gctgttttcg acgggtgtgc aggtttcggc    660

acatggagat tgataaaaaa cgcagtgaaa ttccttgtta ttgggaaaat cagccaacag    720

gatgtcaaaa attaaactgc gctttccatc acaatagagg acgatatgtt gatggccttt    780

tcctacctcc gagcaaaagt gtgttgccca ctgtgcctga gtcaccagaa gaggaagtga    840

aggctagcca actttcagtt cagcagaaca aattgtctgt ccagtccaat ccttcccctc    900

agctgcggag cgttatgaaa gtagaaagtt ccgaaaatgt tcctagcccc aagcatccac    960

cagttgtaat taatgctgca gatgatgatg aagatgatga tgatcagttt tctgaggaag   1020

gtgatgaaac caaaacacct accctgcaac caactcctga agttcacaat ggattacgag   1080

tgacttctgt ccggaaacct gcagtcaata taaagcaagg tgaatgtttg cattttggaa   1140

taaaaactct tgaggaaatt aagtcaaaga aaatgaagga aaaatctgag gagcaaggaa   1200

ctgctgttgt aagcggctca tcaagagttg aacttcacgt agccttgttg ggaatatgga   1260

aaaggaagaa agccacagga ctgcccattc agtcttgtta agattgggat gattctgcac   1320

aagcaaaaat gacttgaaat ttatgtatcg acacacctct accaatccat cttcagctga   1380

ctgaatgttg tatgatagcc cttctccaaa gcaggggtag aatgttcagg tttcaccacg   1440

gattttctac ttatttcgct tttggaatca gcttacagat tccaggtccc ttttgtagat   1500

attctttatt cttttgc                                                  1517


<210>  3269
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  3269

Met Pro Asn Gln Gly Glu Asp Cys Tyr Phe Phe Phe Tyr Ser Thr Cys 
1               5                   10                  15


Thr Lys Gly Asp Ser Cys Pro Phe Arg His Cys Glu Ala Ala Leu Gly 
            20                  25                  30


Asn Glu Thr Val Cys Thr Leu Trp Gln Glu Gly Arg Cys Phe Arg Arg 
        35                  40                  45


Val Cys Arg Phe Arg His Met Glu Ile Asp Lys Lys Arg Ser Glu Ile 
    50                  55                  60


Pro Cys Tyr Trp Glu Asn Gln Pro Thr Gly Cys Gln Lys Leu Asn Cys 
65                  70                  75                  80


Ala Phe His His Asn Arg Gly Arg Tyr Val Asp Gly Leu Phe Leu Pro 
                85                  90                  95


Pro Ser Lys Ser Val Leu Pro Thr Val Pro Glu Ser Pro Glu Glu Glu 
            100                 105                 110


Val Lys Ala Ser Gln Leu Ser Val Gln Gln Asn Lys Leu Ser Val Gln 
        115                 120                 125


Ser Asn Pro Ser Pro Gln Leu Arg Ser Val Met Lys Val Glu Ser Ser 
    130                 135                 140


Glu Asn Val Pro Ser Pro Lys His Pro Pro Val Val Ile Asn Ala Ala 
145                 150                 155                 160


Asp Asp Asp Glu Asp Asp Asp Asp Gln Phe Ser Glu Glu Gly Asp Glu 
                165                 170                 175


Thr Lys Thr Pro Thr Leu Gln Pro Thr Pro Glu Val His Asn Gly Leu 
            180                 185                 190


Arg Val Thr Ser Val Arg Lys Pro Ala Val Asn Ile Lys Gln Gly Glu 
        195                 200                 205


Cys Leu His Phe Gly Ile Lys Thr Leu Glu Glu Ile Lys Ser Lys Lys 
    210                 215                 220


Met Lys Glu Lys Ser Glu Glu Gln Gly Thr Ala Val Val Ser Gly Ser 
225                 230                 235                 240


Ser Arg Val Glu Leu His Val Ala Leu Leu Gly Ile Trp Lys Arg Lys 
                245                 250                 255


Lys Ala Thr Gly Leu Pro Ile Gln Ser Cys 
            260                 265


<210>  3270
<211>  4121
<212>  DNA
<213>  Homo sapiens

<400>  3270
caacagcagt tccttaggag ccaacatgac aggtgggggt cagatttccc tatgagaaac     60

aaaactggcc acctacagca aaatatcaaa atgggtaagt ccttccttcc tcttcctcct    120

gattatatac aacatatctc ctttcaagac tattatttcc atcatgctta ttccttcaca    180

aatctaaacc ttgaggtgat atgaaggaaa ccaacatcaa gaaaagaaaa ctcaattcag    240

aaatgaagaa aactggcagg tatacaatat acccccagag catctcaata tccctggcac    300

agtacaattc agtgtactgc tacagcccat agataaatat tggcagcttg aataagctca    360

ttttttccct caggtggtta aaggccacca cataaatact gggcaacagg ggtttgttgg    420

gagaattaga aataaaaaat taaccatatt ttgtccctgt gttaattcaa tgccagcaag    480

gaggcaagta ctgaagaaga aaagggacaa ttttcatact aaaaaagaat tcctctaatc    540

atgtcaccat ctcatataat gaatccaggg aatcccagaa atagaaaatt agtttcaggg    600

gacccctgag gcactttaaa gccttttaaa aaattacagt aataataaat tagatattgc    660

tcttcagagg ccaacagagc agcagaagca tcaagatcag gtccaaagag ttatgcccac    720

attacaggct tcctgagctg ctcagccctc tttaaagctt agttgaatct ctaaatacct    780

ttaaaaagac atacaatcta acacagactg agtgggtatt tttgtttagt ggtagcataa    840

aatttggtcc ttaatggtag cagctgtctt catccatttc aaactcaggt aatattaagt    900

acatcaagac aatacataaa gaatacaaca aaggagaaaa aagccaaaac tgacaaacac    960

ctcaaggagt cactaagttt gcttgcaccc tttcacttga tctccctctc agtctctttt   1020

ttgtggagag aagggtatga cagaactttt ttctcaaaag atgataaaca atggcatcaa   1080

atggacaaaa tggttataaa gtaactttaa aaatctgacc ccaaggaatc caggacacat   1140

acagataatt cagaggtata cttctgattt ggggcaaatt ctagactaaa gaaatgatca   1200

tctcaggtaa atgttacaat agatgaaact aagtccagtt ttttggcgat ttttttttaa   1260

agtgtcctca ctaccacctt cagctatcaa tcatttctca tagctcaagc ggaaggtcat   1320

cttcatcttt cccaggatcc aggtcaatct cagcttccaa tttgcctcct gaaatctccc   1380

atgttagttt ctcaaaatca tcctccacag agagtggggg ctttcctgtt gaggcagagc   1440

tgagtcggcg agttttcatg ctcatttggg atgaggaagg gccagacacc tccgggggtg   1500

aggaatctga agaggactgg gttagaggca gcacaagact gtctctagga ttttctgttt   1560

caggcacagt gactgatttg tcctcagaga caagcaggac aacagcatcc acagctgcct   1620

ttttggctgg gggttcctgt aggacgctgc tggagctgag tggcttcaca gcggcagtga   1680

cagcagggtg catctccact gccttacgtt ttggggccaa tttgggggat gacacaactt   1740

taaccacaga ttgcttcacg ttcactgtgg gtttagcttc accccttttt tccaaggtct   1800

gtgctgacca tttcacattc aataatgagt ctgcaatccc tgaggtttct acctccacct   1860

tctgggatga ctttgtggga agctgcttgg tcaggtgcca tgtgattcct ggcacagcag   1920

tgagcactgg tttctctgcc acttgggtat tgcaagaggc tacatctccc tgaagaggtg   1980

tcaagactga tttttccctc tcctgctgtt tctgcatgcg cgtctctctc atgatctcac   2040

atctcttgac ttgaatttta gtgatgtcaa ctcctgtggt ctcaactgaa gcctctgtag   2100

cttccattct aacacggctc agaaaatcaa cttcatttcc ttcctgaagt ttcttctctt   2160

ctttcctcca tgttcttttg gtgattcgca gtagcaacct tgcccctgga gtggcctcat   2220

gttgagacgg ggagctggtg ctgctctcag agctctgctg caccctcagt gccttctcca   2280

gtttaatttc ttccaccgtc ttcatgtgca cctcctgcat ggactttgtt ttacctgcag   2340

gctcctctga ttgtcctttg ctggcaacaa tgggtggcaa aactactgtt tttttaattt   2400

cactatcagt ctttagcttg atgcaagttg tatccttttt gcttttttgt ctctctgctt   2460

cctgctgcct atgttcttct tcagccagga cctcagagaa ggttttgata cggatagtgg   2520

aggagcttct tgctcctgaa gtagaatcat cagtttttga aggtccttct gtcttgagtt   2580

tagtttgcga ttccccatgt ttctgactgg ctctttcaag aagcatttct tctaatgtct   2640

tcacatggat ctcaccaact ttattaactt tatctgttgc gtcctcatta tttggatcag   2700

ctgacatgcc taatcgctcc ttaagagact tggaaacttg agctttcttt ggtgtttcgt   2760

cagtgttagt ttctggagct tcaactttct tccctagcct ctgtgccagg ctgcgcttta   2820

atggaggatc actgtcaccg cctgtcgaaa attttcgttt ccccagtgtc tcagtaaggc   2880

ccaatctaac caagggttct tctccttgtt tggtggagag agttactgtc ctcaccacag   2940

tcctgacatt ttctttttca ggacctggaa caggctcagg gtggagtaaa agactggaaa   3000

ctcctgaaga accctcacct tgctcctcag atttttcctt cattttcttt gacttaattt   3060

cctcaagagt ttttattcca aaatgcaaac attcaccttg ctttatattg actgcaggtt   3120

tccggacaga agtcactcgt aatccattgt gaacttcagg agttggttgc agggtaggtg   3180

ttttggtttc atcaccttcc tcagaaaact gatcatcatc atcttcatca tcatctgcag   3240

cattaattac aactggtgga tgcttggggc taggaacatt ttcggaactt tctactttca   3300

taacgctccg cagctgaggg gaaggattgg actggacaga caatttgttc tgctgaactg   3360

aaagttggct agccttcact tcctcttctg gtgactcagg cacagtgggc aacacacttt   3420

tgctcggagg taggaaaagg ccatcaacat atcgtcctct attgtgatgg aaagcgcagt   3480

ttaatttttg acatcctgtt ggctgatttt cccaataaca aggaatttca ctgcgttttt   3540

tatcaatctc catgtgccga aacctgcaca cccgtcgaaa acagcgccct tcttgccata   3600

atgtgcaaac agtttcattg cctagtgcag cttcacagtg acggaatggg cagctgtcac   3660

ctttggtaca tgtagaatag aaaaaaaaat agcagtcttc tccttgatta ggcatgctgg   3720

gtagattctt agatcagaag tggcttcttg aaacaagcca ctgcttcctc aaagcaagga   3780

ccaggctcca agtcctcgtg aaatgggttt aatcttccaa atgacaactt gatcacagaa   3840

attgtcttta aactgtaatc attagctgat tgctctcaac aggaacgtct gtgtcttcac   3900

tgagttccaa tctattacgc ctgtaggtcg aaccaacact caatccatga attaataata   3960

atgaagcaga aaaaattttc ctcctcacat tgccaagaaa acctctcagc cacaattcaa   4020

acacagcatg tgtttttaaa acatctccca actactggga gattaagtcc attcaaataa   4080

cctttgtcag actggagaca gctagggtta gttatctcct c                       4121


<210>  3271
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  3271

Met Leu Ile Trp Asp Glu Glu Gly Pro Asp Thr Ser Gly Gly Glu Glu 
1               5                   10                  15


Ser Glu Glu Asp Trp Val Arg Gly Ser Thr Arg Leu Ser Leu Gly Phe 
            20                  25                  30


Ser Val Ser Gly Thr Val Thr Asp Leu Ser Ser Glu Thr Ser Arg Thr 
        35                  40                  45


Thr Ala Ser Thr Ala Ala Phe Leu Ala Gly Gly Ser Cys Arg Thr Leu 
    50                  55                  60


Leu Glu Leu Ser Gly Phe Thr Ala Ala Val Thr Ala Gly Cys Ile Ser 
65                  70                  75                  80


Thr Ala Leu Arg Phe Gly Ala Asn Leu Gly Asp Asp Thr Thr Leu Thr 
                85                  90                  95


Thr Asp Cys Phe Thr Phe Thr Val Gly Leu Ala Ser Pro Leu Phe Ser 
            100                 105                 110


Lys Val Cys Ala Asp His Phe Thr Phe Asn Asn Glu Ser Ala Ile Pro 
        115                 120                 125


Glu Val Ser Thr Ser Thr Phe Trp Asp Asp Phe Val Gly Ser Cys Leu 
    130                 135                 140


Val Arg Cys His Val Ile Pro Gly Thr Ala Val Ser Thr Gly Phe Ser 
145                 150                 155                 160


Ala Thr Trp Val Leu Gln Glu Ala Thr Ser Pro 
                165                 170


<210>  3272
<211>  5444
<212>  DNA
<213>  Homo sapiens

<400>  3272
agaaacaaag tgatacacgc taggcatgtc cagacattaa ccgtaatcag aagcctccta     60

gggttgcaag cctccttggc taatggttgg gctttgtgcc tcactcttct cttacacctg    120

gggagtcaag tctggatcct ctgctccata tttatttagc aaataaaaca ctgatctcaa    180

acagcaacgg aacctgtgta cttgaggtgt tttttgaaaa ctaatcagaa gaggaatgct    240

tatctcccaa gaaaattgaa accatctgta aaagaatctt ggctgtgctg tgttttgatt    300

agattgaagc ttggtgtaaa gagaaaacac aaaagaccgc agaatattta caacatttga    360

attcctgttt ctccatcaaa gcacattgtc atcaaagcta ctttgggtat agaaaaaagg    420

tcaattccaa ttcccaggaa tccttaacca caactttact tggaaatttc cggtaatact    480

taaaacacca ttttgcagca attctttatg ataaactgta aaatacagct acccgaaaat    540

gactgacaaa tcaatcgtca ttctgagcct gatggttttt cacagctctt tcataaatgg    600

aaaaacatgt agacggcaat tggtggaaga atggcatcca caaccctcat catatgtggt    660

aaattggaca ctaacagaaa acatctgctt ggacttctac agagattgct ggtttttggg    720

tgtaaacact aaaatagata cttcaggcaa tcaagctgtt ccccagattt gccctttgca    780

aattcaatta ggagatatcc ttgtaatttc ttctgaacca tctcttcaat ttccagaaat    840

aaatttgatg aatgtttctg aaacatcttt cgttggctgt gtgcaaaata ccacaacgga    900

agatcagtta ctttttggct gcagactaaa aggaatgcac actgttaatt ctaagtggct    960

gagtgttggg acacattatt ttatcacagt tatggcaagt ggtccatcac cttgtccact   1020

gggacttcga ctaaatgtga cagtgaaaca gcagttctgc caggaatctc tgagttcaga   1080

attttgctct ggtcatggta aatgtcttag tgaagcttgg agcaagacat atagctgcca   1140

ttgccagcct ccattttctg gaaaatactg ccaggaactt gatgcatgtt cttttaaacc   1200

atgtaaaaat aatggcagtt gcattaataa aagagaaaat tgggatgagc aagcatatga   1260

atgtgtctgt cacccaccat ttacaggaaa gaattgctca gaaataattg gccagtgtca   1320

accacatgtc tgtttccatg gaaactgcag caatattact tcaaatagtt tcatttgtga   1380

atgtgatgag caattttcag gtccattctg tgaggtgtca gcaaaacctt gtgtttctct   1440

gcttttttgg aaaagaggaa tttgcccaaa tagcagttct gcttatactt atgaatgccc   1500

aaaaggatct tccagccaaa atggtgaaac tgatgtcagt gagttttcat tagtaccatg   1560

tcagaatggt actgactgca tcaaaatatc aaatgatgtt atgtgcatct gttcaccaat   1620

atttacagat ttgctttgta agagcattca aacatcatgt gagtcatttc ctttgaggaa   1680

taatgctaca tgtaagaaat gtgagaaaga ttatccttgc agctgtatat caggatttac   1740

tgaaaaaaac tgtgagaaag caattgacca ctgtaaactg ctcagcatca actgtctgaa   1800

tgaagaatgg tgtttcaata taattggaag attcaaatat gtatgcattc cagggtgcac   1860

aaaaaatcca tgttggtttt tgaagaatgt ttacctaatt catcaacacc tctgctactg   1920

tggagtcacc ttccatggta tttgccaaga taaaggtcct gctcaatttg aatatgtgtg   1980

gcaattggga tttgcaggat ctgaaggcga aaagtgccaa ggggttattg atgcctattt   2040

ctttctggct gcaaactgca ctgaagatgc aacctatgtg aacgatcctg aagataataa   2100

ttcttcatgt tggttcccac atgaaggcac aaaagagatt tgtgcaaatg gatgcagttg   2160

tttgagtgaa gaagacagtc aggaatatcg gtatctatgt tttctcagat gggctggcaa   2220

catgtatctg gaaaatacaa ctgatgatca agaaaatgag tgtcaacatg aagctgtttg   2280

taaagatgaa attaatagac ccagaagaat cctcaacacg gtgataccac accaaattca   2340

gcaacatata gaaaggttta tacagcatga ccaggtggga tttatcgtaa gaatataagt   2400

ttgatttagt ggcttaaaat caattaatgt aatttaatgt atcaatagaa taaataaaga   2460

agaaaatgca tgataatgta gatggagaaa aaaattgtat tacagaatct cacaacactt   2520

tatgaaacaa acactcaaca aataaagaat aaaagggaac ttccacaatc tgataagaga   2580

agttaaaaaa aaataagaag aatgaagaaa cataactaac attatacttt acggtgaaag   2640

gctgaaagac tggaatttta aatcaaaaca atgagataac actttacacc cagcaattct   2700

acttctagta tatactcaaa aaattgaaaa tatatgttct ttacaaaaat ttatatgtga   2760

atgtttacag ttttgttcga aagagtcaaa aagttgaaac aacccaaatg accatcaact   2820

gatgaatgga tatataaaat ttgttatatc catacaatga aatgttattc agcaatagac   2880

aaagatgaat tactgatatg tgcttcaata cgaataaaca ttgaaaacat tttgataagg   2940

aaaagtagta agccacaaaa gacacataga atagtgctca acaaatactt gtttaatgaa   3000

acaatgattt tcagaagctt ttttatttac taagaaaatt atccttcgtt ttgtgatgtt   3060

atttcctttt ttctgatttt gtgattctct tttgtttgcc attatttttt gatatccaga   3120

gaatcttgga taaattacaa aatttttgta atttatcaac actttaatga gttcttgata   3180

ttgtctcata attaatacta acaatggagc ccaacaaatg ttgcagatac aagtatttta   3240

tataaaatta agtttctcta tatcagttgc aatatctaga aattatatgt gtgataccac   3300

ctgttataat gtcaaaagat atgcaaaatg tttagaatta aaaaaaagat gctctaattc   3360

tccattaaaa agaccctcta tataccacta agctcaatga aaaagagaaa attatatata   3420

cactgaataa atggaaatat aatgcatgga gttaaatatt aggccttaaa ttagctaaaa   3480

tattaattct tcccaaatta attcacacat ttaatgcaat agtaaaaata ttgcaagtta   3540

ttttagaaac taattatcat gttatatata tttatgaata atattttcta aattatgaag   3600

tcatctttga aaaggaagac taatggggtg ggatctgatg aaccatatga catgacagac   3660

tacataacac atatgggtgc ctttaaagga aaaaaaataa taatgggtca acagagagct   3720

ctgacaacaa cccgagtata tacgggaact caatatatga gaaatttggc tataatctca   3780

tttgaacata cagggttctt tagtaaatgg tattgaggaa atggctcata ataagacctt   3840

aaatgaaact ggattacaac cttatacctt atatagaagt agactctaaa tgtgtatagg   3900

gatctaaaag tttaaggtaa aatgacgata taaatgaaag aaatgtagaa aaatatcttt   3960

gtgatttcgg gatggagaaa tttttcaatt aaactcaatt tataaggcaa aataatgata   4020

gtattataat gatagacact aataatgttg atgatgttaa cggacacaaa gttaatgaat   4080

agcgtataaa cattttcttt taaagtgtat tttaaatggg tgcagattaa aattcattat   4140

ataaatgatg tattgcaaac aggtctgcat attaccacat ttttttgccc tgaaatcttc   4200

aaaaaatttt tctgggggtt tataaaatgt ttaatgagcc aaagactaaa tcataccagc   4260

catattgtta cttaagacca ggaaagattt gctaagtctg ggatgttaat ttcttaatac   4320

catgcccaga ctgtgaagtg ttcatgactc ccacctgttt ttgaagcctc aaatttatgt   4380

ctaagtcacc aatccctact tgctaccaga aatatcataa cagaatgaaa tatattcatt   4440

catacattta ttatttattg aatctcctct aactggaaga tatttttcaa aatgttatga   4500

caatgagaca tgatacctgt ccccaggtaa tgtactatac ataggtaaga ttatacactc   4560

ttcagaacac atctcatggt tcttctgttt catttagaaa gtgaacacat ttttaaagta   4620

ctaaagtaat tatttttttc actttctgaa catacaagtt gcttgattat agcagtgtgt   4680

cttctggctt tctttctgga agttttaaat ttaacctgtt tcctttacag gctattttag   4740

gagattcaca ttttctgtgt aatgttaaat atatccaaaa cataattttc agttataagt   4800

aagagttctg tttcaaagtg tagaatctaa aagtccataa gaaaatcagg tgaagtttca   4860

aaaactattt ctgtagagtc aggaggcttg taaaaataga gctttatgtg aatatggcac   4920

aaaagtatag tataatttga ccaggatttt cttaaattat ttctgatccc aaaagtctaa   4980

taattattta ttctaagact attgtaattt ctgccgtgat gtccgtgatt ttattaacaa   5040

gttgaatagt tggttttagg tttatttatt tattttggct atactatgca aacttttctg   5100

ccttcaagta aaagttttat gtgggtatat ttttaccttt aaagcaaaaa agatatcgaa   5160

ctgcatatga aagtgtcata ttgaatgtat ttttgggttg gggccagtct tgaaaccact   5220

agatcaagtg tctaaatctt tttgtctaag gcacttacat acactgatat attttctctc   5280

tttattatgc tctagaaaac caaataatct tggttcttaa atccttatag taaaatgata   5340

tagaaatcat tcatttaagc aattctagag tacatatcat tgtattaccc atacacatac   5400

caaaattatt ataacaaact tcattaaatg aagcattttt gaat                    5444


<210>  3273
<211>  619
<212>  PRT
<213>  Homo sapiens

<400>  3273

Met Thr Asp Lys Ser Ile Val Ile Leu Ser Leu Met Val Phe His Ser 
1               5                   10                  15


Ser Phe Ile Asn Gly Lys Thr Cys Arg Arg Gln Leu Val Glu Glu Trp 
            20                  25                  30


His Pro Gln Pro Ser Ser Tyr Val Val Asn Trp Thr Leu Thr Glu Asn 
        35                  40                  45


Ile Cys Leu Asp Phe Tyr Arg Asp Cys Trp Phe Leu Gly Val Asn Thr 
    50                  55                  60


Lys Ile Asp Thr Ser Gly Asn Gln Ala Val Pro Gln Ile Cys Pro Leu 
65                  70                  75                  80


Gln Ile Gln Leu Gly Asp Ile Leu Val Ile Ser Ser Glu Pro Ser Leu 
                85                  90                  95


Gln Phe Pro Glu Ile Asn Leu Met Asn Val Ser Glu Thr Ser Phe Val 
            100                 105                 110


Gly Cys Val Gln Asn Thr Thr Thr Glu Asp Gln Leu Leu Phe Gly Cys 
        115                 120                 125


Arg Leu Lys Gly Met His Thr Val Asn Ser Lys Trp Leu Ser Val Gly 
    130                 135                 140


Thr His Tyr Phe Ile Thr Val Met Ala Ser Gly Pro Ser Pro Cys Pro 
145                 150                 155                 160


Leu Gly Leu Arg Leu Asn Val Thr Val Lys Gln Gln Phe Cys Gln Glu 
                165                 170                 175


Ser Leu Ser Ser Glu Phe Cys Ser Gly His Gly Lys Cys Leu Ser Glu 
            180                 185                 190


Ala Trp Ser Lys Thr Tyr Ser Cys His Cys Gln Pro Pro Phe Ser Gly 
        195                 200                 205


Lys Tyr Cys Gln Glu Leu Asp Ala Cys Ser Phe Lys Pro Cys Lys Asn 
    210                 215                 220


Asn Gly Ser Cys Ile Asn Lys Arg Glu Asn Trp Asp Glu Gln Ala Tyr 
225                 230                 235                 240


Glu Cys Val Cys His Pro Pro Phe Thr Gly Lys Asn Cys Ser Glu Ile 
                245                 250                 255


Ile Gly Gln Cys Gln Pro His Val Cys Phe His Gly Asn Cys Ser Asn 
            260                 265                 270


Ile Thr Ser Asn Ser Phe Ile Cys Glu Cys Asp Glu Gln Phe Ser Gly 
        275                 280                 285


Pro Phe Cys Glu Val Ser Ala Lys Pro Cys Val Ser Leu Leu Phe Trp 
    290                 295                 300


Lys Arg Gly Ile Cys Pro Asn Ser Ser Ser Ala Tyr Thr Tyr Glu Cys 
305                 310                 315                 320


Pro Lys Gly Ser Ser Ser Gln Asn Gly Glu Thr Asp Val Ser Glu Phe 
                325                 330                 335


Ser Leu Val Pro Cys Gln Asn Gly Thr Asp Cys Ile Lys Ile Ser Asn 
            340                 345                 350


Asp Val Met Cys Ile Cys Ser Pro Ile Phe Thr Asp Leu Leu Cys Lys 
        355                 360                 365


Ser Ile Gln Thr Ser Cys Glu Ser Phe Pro Leu Arg Asn Asn Ala Thr 
    370                 375                 380


Cys Lys Lys Cys Glu Lys Asp Tyr Pro Cys Ser Cys Ile Ser Gly Phe 
385                 390                 395                 400


Thr Glu Lys Asn Cys Glu Lys Ala Ile Asp His Cys Lys Leu Leu Ser 
                405                 410                 415


Ile Asn Cys Leu Asn Glu Glu Trp Cys Phe Asn Ile Ile Gly Arg Phe 
            420                 425                 430


Lys Tyr Val Cys Ile Pro Gly Cys Thr Lys Asn Pro Cys Trp Phe Leu 
        435                 440                 445


Lys Asn Val Tyr Leu Ile His Gln His Leu Cys Tyr Cys Gly Val Thr 
    450                 455                 460


Phe His Gly Ile Cys Gln Asp Lys Gly Pro Ala Gln Phe Glu Tyr Val 
465                 470                 475                 480


Trp Gln Leu Gly Phe Ala Gly Ser Glu Gly Glu Lys Cys Gln Gly Val 
                485                 490                 495


Ile Asp Ala Tyr Phe Phe Leu Ala Ala Asn Cys Thr Glu Asp Ala Thr 
            500                 505                 510


Tyr Val Asn Asp Pro Glu Asp Asn Asn Ser Ser Cys Trp Phe Pro His 
        515                 520                 525


Glu Gly Thr Lys Glu Ile Cys Ala Asn Gly Cys Ser Cys Leu Ser Glu 
    530                 535                 540


Glu Asp Ser Gln Glu Tyr Arg Tyr Leu Cys Phe Leu Arg Trp Ala Gly 
545                 550                 555                 560


Asn Met Tyr Leu Glu Asn Thr Thr Asp Asp Gln Glu Asn Glu Cys Gln 
                565                 570                 575


His Glu Ala Val Cys Lys Asp Glu Ile Asn Arg Pro Arg Arg Ile Leu 
            580                 585                 590


Asn Thr Val Ile Pro His Gln Ile Gln Gln His Ile Glu Arg Phe Ile 
        595                 600                 605


Gln His Asp Gln Val Gly Phe Ile Val Arg Ile 
    610                 615


<210>  3274
<211>  2230
<212>  DNA
<213>  Homo sapiens

<400>  3274
caaaattcat atgttgcaac atttaccctt agtgtgacta tatttggaga tagggctttt     60

aggaggtgtt ttttgaaaac taatcagaag aggaatgctt atctcccaag aaaattgaaa    120

ccatctgtaa aagaatcttg gctgtgctgt gttttgatta gattgaagct tggtgtaaag    180

agaaaacaca aaagaccgca gaatatttac aacatttgaa ttcctgtttc tccatcaaag    240

cacattgtca tcaaagctac tttgggtata gaaaaaaggt caattccaat tcccaggaat    300

ccttaaccac aactttactt ggaaatttcc ggtaatactt aaaacaccat tttgcagcaa    360

ttctttatga taaactgtaa aatacagcta cccgaaaatg actgacaaat caatcgtcat    420

tctgagcctg atggtttttc acagctcttt cataaatgga aaaacatgta gacggcaatt    480

ggtggaagaa tggcatccac aaccctcatc atatgtggta aattggacac taacagaaaa    540

catctgcttg gacttctaca gagattgctg gtttttgggt gtaaacacta aaatagatac    600

ttcaggcaat caagctgttc cccagatttg ccctttgcaa attcaattag gagatatcct    660

tgtaatttct tctgaaccat ctcttcaatt tccagaaata aatttgatga atgtttctga    720

aacatctttc gttggctgtg tgcaaaatac cacaacggaa gatcagttac tttttggctg    780

cagactaaaa ggaatgcaca ctgttaattc taagtggctg agtgttggga cacattattt    840

tatcacagtt atggcaagtg gtccatcacc ttgtccactg ggacttcgac taaatgtgac    900

agtgaaacag cagttctgcc aggaatctct gagttcagaa ttttgctctg gtcatggtaa    960

atgtcttagt gaagcttgga gcaagacata tagctgccat tgccagcctc cattttctgg   1020

aaaatactgc caggaacttg atgcatgttc ttttaaacca tgtaaaaata atggcagttg   1080

cattaataaa agagaaaatt gggatgagca agcatatgaa tgtgtctgtc acccaccatt   1140

tacaggaaag aattgctcag aaataattgg ccagtgtcaa ccacatgtct gtttccatgg   1200

aaactgcagc aatattactt caaatagttt catttgtgaa tgtgatgagc aattttcagg   1260

tccattctgt gaggtgtcag caaaaccttg tgtttctctg cttttttgga aaagaggaat   1320

ttgcccaaat agcagttctg cttatactta tgaatgccca aaaggatctt ccagccaaaa   1380

tggtgaaact gatgtcagtg agttttcatt agtaccatgt cagaatggta ctgactgcat   1440

caaaatatca aatgatgtta tgtgcatctg ttcaccaata tttacagatt tgctttgtaa   1500

gagcattcaa acatcatgtg agtcatttcc tttgaggaat aatgctacat gtaagaaatg   1560

tgagaaagat tatccttgca gctgtatatc aggatttact gaaaaaaact gtgagaaagc   1620

aattgaccac tgtaaactgc tcagcatcaa ctgtctgaat gaagaatggt gtttcaatat   1680

aattggaaga ttcaaatatg tatgcattcc agggtgcaca aaaaatccat gttggttttt   1740

gaagaatgtt tacctaattc atcaacacct ctgctactgt ggagtcacct tccatggtat   1800

ttgccaagat aaaggtcctg ctcaatttga atatgtgtgg caattgggat ttgcaggatc   1860

tgaaggcgaa aagtgccaag gggttattga tgcctatttc tttctggctg caaactgcac   1920

tgaagatgca acctatgtga acgatcctga agataataat tcttcatgtt ggttcccaca   1980

tgaaggcaca aaagagattt gtgcaaatgg atgcagttgt ttgagtgaag aagacagtca   2040

ggaatatcgg tatctatgtt ttctcagatg ggctggcaac atgtatctgg aaaatacaac   2100

tgatgatcaa gaaaatgagt gtcaacatga agctgtttgt aaagatgaaa ttaatagacc   2160

caggtattta tgtatcattt gagcagataa tatcacatat caaaaagtta taattaaatt   2220

gatagtcatc                                                          2230


<210>  3275
<211>  594
<212>  PRT
<213>  Homo sapiens

<400>  3275

Met Thr Asp Lys Ser Ile Val Ile Leu Ser Leu Met Val Phe His Ser 
1               5                   10                  15


Ser Phe Ile Asn Gly Lys Thr Cys Arg Arg Gln Leu Val Glu Glu Trp 
            20                  25                  30


His Pro Gln Pro Ser Ser Tyr Val Val Asn Trp Thr Leu Thr Glu Asn 
        35                  40                  45


Ile Cys Leu Asp Phe Tyr Arg Asp Cys Trp Phe Leu Gly Val Asn Thr 
    50                  55                  60


Lys Ile Asp Thr Ser Gly Asn Gln Ala Val Pro Gln Ile Cys Pro Leu 
65                  70                  75                  80


Gln Ile Gln Leu Gly Asp Ile Leu Val Ile Ser Ser Glu Pro Ser Leu 
                85                  90                  95


Gln Phe Pro Glu Ile Asn Leu Met Asn Val Ser Glu Thr Ser Phe Val 
            100                 105                 110


Gly Cys Val Gln Asn Thr Thr Thr Glu Asp Gln Leu Leu Phe Gly Cys 
        115                 120                 125


Arg Leu Lys Gly Met His Thr Val Asn Ser Lys Trp Leu Ser Val Gly 
    130                 135                 140


Thr His Tyr Phe Ile Thr Val Met Ala Ser Gly Pro Ser Pro Cys Pro 
145                 150                 155                 160


Leu Gly Leu Arg Leu Asn Val Thr Val Lys Gln Gln Phe Cys Gln Glu 
                165                 170                 175


Ser Leu Ser Ser Glu Phe Cys Ser Gly His Gly Lys Cys Leu Ser Glu 
            180                 185                 190


Ala Trp Ser Lys Thr Tyr Ser Cys His Cys Gln Pro Pro Phe Ser Gly 
        195                 200                 205


Lys Tyr Cys Gln Glu Leu Asp Ala Cys Ser Phe Lys Pro Cys Lys Asn 
    210                 215                 220


Asn Gly Ser Cys Ile Asn Lys Arg Glu Asn Trp Asp Glu Gln Ala Tyr 
225                 230                 235                 240


Glu Cys Val Cys His Pro Pro Phe Thr Gly Lys Asn Cys Ser Glu Ile 
                245                 250                 255


Ile Gly Gln Cys Gln Pro His Val Cys Phe His Gly Asn Cys Ser Asn 
            260                 265                 270


Ile Thr Ser Asn Ser Phe Ile Cys Glu Cys Asp Glu Gln Phe Ser Gly 
        275                 280                 285


Pro Phe Cys Glu Val Ser Ala Lys Pro Cys Val Ser Leu Leu Phe Trp 
    290                 295                 300


Lys Arg Gly Ile Cys Pro Asn Ser Ser Ser Ala Tyr Thr Tyr Glu Cys 
305                 310                 315                 320


Pro Lys Gly Ser Ser Ser Gln Asn Gly Glu Thr Asp Val Ser Glu Phe 
                325                 330                 335


Ser Leu Val Pro Cys Gln Asn Gly Thr Asp Cys Ile Lys Ile Ser Asn 
            340                 345                 350


Asp Val Met Cys Ile Cys Ser Pro Ile Phe Thr Asp Leu Leu Cys Lys 
        355                 360                 365


Ser Ile Gln Thr Ser Cys Glu Ser Phe Pro Leu Arg Asn Asn Ala Thr 
    370                 375                 380


Cys Lys Lys Cys Glu Lys Asp Tyr Pro Cys Ser Cys Ile Ser Gly Phe 
385                 390                 395                 400


Thr Glu Lys Asn Cys Glu Lys Ala Ile Asp His Cys Lys Leu Leu Ser 
                405                 410                 415


Ile Asn Cys Leu Asn Glu Glu Trp Cys Phe Asn Ile Ile Gly Arg Phe 
            420                 425                 430


Lys Tyr Val Cys Ile Pro Gly Cys Thr Lys Asn Pro Cys Trp Phe Leu 
        435                 440                 445


Lys Asn Val Tyr Leu Ile His Gln His Leu Cys Tyr Cys Gly Val Thr 
    450                 455                 460


Phe His Gly Ile Cys Gln Asp Lys Gly Pro Ala Gln Phe Glu Tyr Val 
465                 470                 475                 480


Trp Gln Leu Gly Phe Ala Gly Ser Glu Gly Glu Lys Cys Gln Gly Val 
                485                 490                 495


Ile Asp Ala Tyr Phe Phe Leu Ala Ala Asn Cys Thr Glu Asp Ala Thr 
            500                 505                 510


Tyr Val Asn Asp Pro Glu Asp Asn Asn Ser Ser Cys Trp Phe Pro His 
        515                 520                 525


Glu Gly Thr Lys Glu Ile Cys Ala Asn Gly Cys Ser Cys Leu Ser Glu 
    530                 535                 540


Glu Asp Ser Gln Glu Tyr Arg Tyr Leu Cys Phe Leu Arg Trp Ala Gly 
545                 550                 555                 560


Asn Met Tyr Leu Glu Asn Thr Thr Asp Asp Gln Glu Asn Glu Cys Gln 
                565                 570                 575


His Glu Ala Val Cys Lys Asp Glu Ile Asn Arg Pro Arg Tyr Leu Cys 
            580                 585                 590


Ile Ile 



<210>  3276
<211>  5922
<212>  DNA
<213>  Homo sapiens

<400>  3276
actgcgcgcc ggcgcgcaca cccgagacag agctttacta tctcgctccc tctcgcgcct     60

ccctcctcgc tgggcattca aacagctttc cgacatcacc agccaaggat ttttttcccc    120

gctctcctta gtcgccgtcc gtccatcagt acctgcaggg gggaggagga ggagggagga    180

aagcggaaag aggaaaaagc ataagcttga gccttccgat ccgaccacga atactcctgt    240

aataaaccca ccgccccaac aaatctgcca tagcagccgc cgccgccgcc ggtcacttct    300

cgtctcagcg ctttctttgc ttcttggttt gttgggggta gcttttatga aacaaatctt    360

tgctattaag ccacttacat tttggggggt tccttagagt ctcccttggg ggggcttctc    420

cctcccttta gcccccctcg gtttggaggt tggattcagt tggatacggc gcaaggttct    480

gggctcctgc tggctttttt ttcctctctc tcatcgaccc ccctttggtt cccacccccc    540

accttttgct tttcgtatgt atgcattttt aaaaataaat cctgattttg gaagctgagc    600

cggggaaaat gggcaacggt gattgggacc gaaggggagt ctctccgtca ctgttgctgg    660

gacgcgtgcc tgtgctggtg tcttagagca agagcctccc tgagctttcg gagtggaagg    720

ccaaatgaca taggatgaag gctgttcgta acctgctgat ttatatattt tccacctatc    780

tcctggttat gtttggattt aatgctgccc aagacttctg gtgttcaact ttggtgaagg    840

gagtcattta tggatcgtat tctgtaagtg aaatgtttcc taaaaacttt acaaactgca    900

cttggacgct ggaaaatcca gatccaacca aatatagcat ttacctgaaa ttttccaaaa    960

aggaccttag ctgctctaac ttttcactcc tggcttatca gtttgatcat ttttcccatg   1020

aaaaaataaa ggatctttta agaaagaatc attctataat gcaactctgc aattccaaga   1080

atgctttcgt ttttctacag tatgataaaa attttattca aatacgtcga gtatttccaa   1140

ctaatttccc aggattacag aaaaaagggg aagaagatca gaaatctttt tttgagtttt   1200

tggtattgaa caaggtcagc ccaagccagt ttggttgcca tgtattatgt acttggttgg   1260

agagctgctt aaaatcagaa aatgggagaa cagaatcatg tgggatcatg tatacaaaat   1320

gcacctgccc tcagcatttg ggagagtggg ggatcgacga ccagtcgctg attttgttaa   1380

ataacgtggt gttacccctg aatgagcaga cagagggctg cctgacccag gagctgcaaa   1440

ccacccaagt ctgcaatctt accagggagg ccaagcgacc acccaaagaa gaatttggaa   1500

tgatgggaga tcatacaatt aaaagtcagc gacctcgatc tgttcatgaa aaaagggtcc   1560

ctcaggaaca agctgatgct gctaaattta tggcacaaac tggtgaatct ggtgtggaag   1620

agtggtccca gtggagcaca tgttcggtta cttgtggtca agggtcgcag gtgcgaacca   1680

gaacttgtgt atcaccttac gggacacact gcagcggccc attaagagaa tcaagggttt   1740

gcaataacac tgccctctgt ccagtacacg gagtatggga ggaatggtca ccatggagtt   1800

tatgttcatt tacatgtggt cgaggccaaa gaacaagaac aaggtcatgc acacctcctc   1860

agtatggagg aaggccgtgt gaaggacctg aaacacatca taagccttgt aatattgctc   1920

tttgcccagt tgatggacag tggcaagagt ggagttcgtg gagccagtgc tcagtaacgt   1980

gctcgaatgg gactcagcag agaagccggc agtgcactgc agctgcccat ggaggctccg   2040

aatgcagagg gccatgggca gaaagcagag agtgctataa ccctgaatgt acagccaatg   2100

gtcaatggaa tcagtggggt cattggagtg gttgttccaa gtcctgtgat ggcggctggg   2160

aaaggcgaat aaggacctgt cagggtgcag tgataacagg gcagcaatgt gaaggaacgg   2220

gcgaagaagt gagaagatgc aatgagcagc gatgccctgc accttatgaa atatgccctg   2280

aggattatct gatgtcgatg gtgtggaaaa gaactccagc aggcgacttg gcattcaatc   2340

aatgtcccct gaatgccaca ggcaccacta gcagacgctg ctctctcagt cttcatggag   2400

tggccttctg ggaacagccg agctttgcaa gatgcatatc aaatgagtac agacacttgc   2460

agcattcaat taaagagcac cttgctaagg ggcagcgaat gctggcaggt gatggaatgt   2520

cccaggtgac caagacactg ttggatttaa ctcagagaaa aaatttctat gcaggcgatc   2580

ttctgatgtc tgtggagatc ctgagaaatg tgacagacac atttaaaagg gcaagttaca   2640

tccctgcatc tgatggtgtc cagaacttct ttcaaatagt tagcaacctt ctagatgaag   2700

aaaacaagga aaaatgggaa gatgcacaac agatttatcc agggtcaata gagttaatgc   2760

aggtgattga agattttata cacattgttg gaatggggat gatggacttt cagaattcat   2820

acttaatgac tggaaatgta gtggctagta ttcagaagct tcctgcagcc tctgttctaa   2880

cagacatcaa ctttccaatg aaaggacgga agggaatggt tgactgggca agaaactcag   2940

aagatagggt agtaattcca aaaagcattt tcactccggt gtcatcaaaa gaattagatg   3000

aatcatctgt atttgttctt ggcgcagtcc tatacaaaaa cttagatcta attttgccca   3060

ctttgagaaa ttatactgtc attaattcca aaatcatcgt ggtcacaata aggcctgaac   3120

ccaaaacaac cgattcgttt ctggagatag aactagctca tttggctaat ggtactttga   3180

atccctattg tgtattgtgg gatgactcca aaacgaacga gtctttggga acgtggtcca   3240

cccagggatg taaaactgtg cttaccgatg catcccatac gaaatgctta tgtgatcgtc   3300

tctctacctt cgccattttg gctcagcaac ctagagaaat aatcatggaa tcctctggca   3360

caccttcagt taccctaata gtaggcagtg gtctttcttg cttggccttg attaccctag   3420

cagttgtcta tgcagcatta tggaggtaca tacgctctga gagatccata atactaatta   3480

acttctgcct gtctatcatc tcatccaata tcctcatact ggttggacag actcagacac   3540

ataataagag tatctgcaca accaccactg catttttgca ctttttcttc ctggcttcat   3600

tctgttgggt tttgactgag gcgtggcaat catatatggc tgtaactgga aaaattagga   3660

cacggcttat aagaaaacgc tttttgtgcc ttggatgggg tttaccagca ttagtagtgg   3720

ccacatcagt aggcttcacc agaacaaaag gatatggcac tgatcactac tgctggctct   3780

ctcttgaagg aggactactc tatgcttttg tgggacctgc agccgctgtt gtcctggtca   3840

acatggtgat tggcattttg gtatttaata aacttgtttc cagagatgga atcctagata   3900

aaaagctcaa acacagagcc ggtcagatga gtgagcctca tagcggtttg acgctcaaat   3960

gtgccaagtg tggagtagtt tcaacaacag ctttgtcagc caccaccgcc agtaacgcca   4020

tggcgtctct ttggagctcc tgtgtggtgt tgccccttct ggctttgacg tggatgtctg   4080

cggttctggc catgacagat aaacgctcca tattgtttca aatacttttt gctgtgtttg   4140

attcattgca aggctttgtt atagtcatgg tccactgcat tcttcggaga gaggttcagg   4200

atgcatttag atgccgattg agaaactgtc aggatcccat caatgcagat tcttcgagtt   4260

cgtttcctaa tgggcatgct caaatcatga cagactttga aaaggatgta gacattgcct   4320

gtcgatcagt tcttcataag gatattggtc cttgccgagc agccacaata acaggaacac   4380

tttctaggat ttctctaaat gatgatgaag aagaaaaggg aacaaaccct gaagggctaa   4440

gctattcaac attgcctgga aatgtcattt ccaaagtcat catccagcaa cccacaggtt   4500

tgcacatgcc catgagtatg aatgagctta gcaatccatg tttgaaaaaa gaaaatagtg   4560

aattgcggag aactgtgtac ttatgtacgg atgataattt gagaggggct gacatggaca   4620

tagtccatcc tcaagaaaga atgatggaaa gtgactatat tgtgatgccc agaagttctg   4680

taaataacca gccttcaatg aaagaagaaa gcaaaatgaa tattggcatg gaaaccttgc   4740

cgcatgaaag gctattgcac tacaaagtaa accctgaatt caatatgaat ccccctgtaa   4800

tggaccagtt caatatgaac ttagagcaac atctcgcacc ccaggaacat atgcagaatt   4860

tgccctttga acctcgcaca gctgtgaaga atttcatggc ctctgagttg gatgataatg   4920

caggactatc aagaagtgaa actggatcaa cgatatcaat gagttcttta gagagaagaa   4980

aatcacgata ttcagacctt gactttgaga aggtcatgca tacaaggaag aggcatatgg   5040

aactatttca agaactaaat cagaaatttc aaactttgga cagatttcgg gatataccaa   5100

atacaagcag tatggaaaac cccgcaccaa acaagaatcc atgggacact ttcaaaaacc   5160

ccagtgaata cccgcattac accacaatca atgtcttaga cacagaggca aaggatgctt   5220

tggaactgag gccagcagag tgggagaagt gtctgaattt gcctctggat gtgcaagagg   5280

gtgactttca aacagaagtt taaaaaaatc aaaatggact aaggtagaga caaaacttta   5340

ttgcactgac acttaagact tgggaagcct gacatttcta tctggacagt gtgactatct   5400

tatgtcagga ccttcatgtg ccaaacgtca gtggtgtttt catatggtaa cttctcacta   5460

gtcaggctag tggagagatg accaggtgta cagttctgac catcctgtgt tgtaagtacc   5520

cgtggaatgg atttgtaagg taatctttat agataaacct caagcaacga ttcatgttgt   5580

aaccgcttca tatggtttag ttttcaaaaa acttcaccat gaagcacaat gtatatattt   5640

atgcagtttt taaagtttat aacagtctgt ttggccatta ctacactttt tactttataa   5700

tataaaagca aagtttttgt cattaaatga atgtttgttg agctacattc ttcattgctt   5760

taaatgcaat aaagtaataa tctcactttt atatgaataa tatatttcac atctttatta   5820

ttgcagtttt ctctagaaag ctctgagaag ctttctctgc tgcagctgtg tataaaatat   5880

ttaaaatgtt gtatggtgta aataaacttt tgtctacata tc                      5922


<210>  3277
<211>  1522
<212>  PRT
<213>  Homo sapiens

<400>  3277

Met Lys Ala Val Arg Asn Leu Leu Ile Tyr Ile Phe Ser Thr Tyr Leu 
1               5                   10                  15


Leu Val Met Phe Gly Phe Asn Ala Ala Gln Asp Phe Trp Cys Ser Thr 
            20                  25                  30


Leu Val Lys Gly Val Ile Tyr Gly Ser Tyr Ser Val Ser Glu Met Phe 
        35                  40                  45


Pro Lys Asn Phe Thr Asn Cys Thr Trp Thr Leu Glu Asn Pro Asp Pro 
    50                  55                  60


Thr Lys Tyr Ser Ile Tyr Leu Lys Phe Ser Lys Lys Asp Leu Ser Cys 
65                  70                  75                  80


Ser Asn Phe Ser Leu Leu Ala Tyr Gln Phe Asp His Phe Ser His Glu 
                85                  90                  95


Lys Ile Lys Asp Leu Leu Arg Lys Asn His Ser Ile Met Gln Leu Cys 
            100                 105                 110


Asn Ser Lys Asn Ala Phe Val Phe Leu Gln Tyr Asp Lys Asn Phe Ile 
        115                 120                 125


Gln Ile Arg Arg Val Phe Pro Thr Asn Phe Pro Gly Leu Gln Lys Lys 
    130                 135                 140


Gly Glu Glu Asp Gln Lys Ser Phe Phe Glu Phe Leu Val Leu Asn Lys 
145                 150                 155                 160


Val Ser Pro Ser Gln Phe Gly Cys His Val Leu Cys Thr Trp Leu Glu 
                165                 170                 175


Ser Cys Leu Lys Ser Glu Asn Gly Arg Thr Glu Ser Cys Gly Ile Met 
            180                 185                 190


Tyr Thr Lys Cys Thr Cys Pro Gln His Leu Gly Glu Trp Gly Ile Asp 
        195                 200                 205


Asp Gln Ser Leu Ile Leu Leu Asn Asn Val Val Leu Pro Leu Asn Glu 
    210                 215                 220


Gln Thr Glu Gly Cys Leu Thr Gln Glu Leu Gln Thr Thr Gln Val Cys 
225                 230                 235                 240


Asn Leu Thr Arg Glu Ala Lys Arg Pro Pro Lys Glu Glu Phe Gly Met 
                245                 250                 255


Met Gly Asp His Thr Ile Lys Ser Gln Arg Pro Arg Ser Val His Glu 
            260                 265                 270


Lys Arg Val Pro Gln Glu Gln Ala Asp Ala Ala Lys Phe Met Ala Gln 
        275                 280                 285


Thr Gly Glu Ser Gly Val Glu Glu Trp Ser Gln Trp Ser Thr Cys Ser 
    290                 295                 300


Val Thr Cys Gly Gln Gly Ser Gln Val Arg Thr Arg Thr Cys Val Ser 
305                 310                 315                 320


Pro Tyr Gly Thr His Cys Ser Gly Pro Leu Arg Glu Ser Arg Val Cys 
                325                 330                 335


Asn Asn Thr Ala Leu Cys Pro Val His Gly Val Trp Glu Glu Trp Ser 
            340                 345                 350


Pro Trp Ser Leu Cys Ser Phe Thr Cys Gly Arg Gly Gln Arg Thr Arg 
        355                 360                 365


Thr Arg Ser Cys Thr Pro Pro Gln Tyr Gly Gly Arg Pro Cys Glu Gly 
    370                 375                 380


Pro Glu Thr His His Lys Pro Cys Asn Ile Ala Leu Cys Pro Val Asp 
385                 390                 395                 400


Gly Gln Trp Gln Glu Trp Ser Ser Trp Ser Gln Cys Ser Val Thr Cys 
                405                 410                 415


Ser Asn Gly Thr Gln Gln Arg Ser Arg Gln Cys Thr Ala Ala Ala His 
            420                 425                 430


Gly Gly Ser Glu Cys Arg Gly Pro Trp Ala Glu Ser Arg Glu Cys Tyr 
        435                 440                 445


Asn Pro Glu Cys Thr Ala Asn Gly Gln Trp Asn Gln Trp Gly His Trp 
    450                 455                 460


Ser Gly Cys Ser Lys Ser Cys Asp Gly Gly Trp Glu Arg Arg Ile Arg 
465                 470                 475                 480


Thr Cys Gln Gly Ala Val Ile Thr Gly Gln Gln Cys Glu Gly Thr Gly 
                485                 490                 495


Glu Glu Val Arg Arg Cys Asn Glu Gln Arg Cys Pro Ala Pro Tyr Glu 
            500                 505                 510


Ile Cys Pro Glu Asp Tyr Leu Met Ser Met Val Trp Lys Arg Thr Pro 
        515                 520                 525


Ala Gly Asp Leu Ala Phe Asn Gln Cys Pro Leu Asn Ala Thr Gly Thr 
    530                 535                 540


Thr Ser Arg Arg Cys Ser Leu Ser Leu His Gly Val Ala Phe Trp Glu 
545                 550                 555                 560


Gln Pro Ser Phe Ala Arg Cys Ile Ser Asn Glu Tyr Arg His Leu Gln 
                565                 570                 575


His Ser Ile Lys Glu His Leu Ala Lys Gly Gln Arg Met Leu Ala Gly 
            580                 585                 590


Asp Gly Met Ser Gln Val Thr Lys Thr Leu Leu Asp Leu Thr Gln Arg 
        595                 600                 605


Lys Asn Phe Tyr Ala Gly Asp Leu Leu Met Ser Val Glu Ile Leu Arg 
    610                 615                 620


Asn Val Thr Asp Thr Phe Lys Arg Ala Ser Tyr Ile Pro Ala Ser Asp 
625                 630                 635                 640


Gly Val Gln Asn Phe Phe Gln Ile Val Ser Asn Leu Leu Asp Glu Glu 
                645                 650                 655


Asn Lys Glu Lys Trp Glu Asp Ala Gln Gln Ile Tyr Pro Gly Ser Ile 
            660                 665                 670


Glu Leu Met Gln Val Ile Glu Asp Phe Ile His Ile Val Gly Met Gly 
        675                 680                 685


Met Met Asp Phe Gln Asn Ser Tyr Leu Met Thr Gly Asn Val Val Ala 
    690                 695                 700


Ser Ile Gln Lys Leu Pro Ala Ala Ser Val Leu Thr Asp Ile Asn Phe 
705                 710                 715                 720


Pro Met Lys Gly Arg Lys Gly Met Val Asp Trp Ala Arg Asn Ser Glu 
                725                 730                 735


Asp Arg Val Val Ile Pro Lys Ser Ile Phe Thr Pro Val Ser Ser Lys 
            740                 745                 750


Glu Leu Asp Glu Ser Ser Val Phe Val Leu Gly Ala Val Leu Tyr Lys 
        755                 760                 765


Asn Leu Asp Leu Ile Leu Pro Thr Leu Arg Asn Tyr Thr Val Ile Asn 
    770                 775                 780


Ser Lys Ile Ile Val Val Thr Ile Arg Pro Glu Pro Lys Thr Thr Asp 
785                 790                 795                 800


Ser Phe Leu Glu Ile Glu Leu Ala His Leu Ala Asn Gly Thr Leu Asn 
                805                 810                 815


Pro Tyr Cys Val Leu Trp Asp Asp Ser Lys Thr Asn Glu Ser Leu Gly 
            820                 825                 830


Thr Trp Ser Thr Gln Gly Cys Lys Thr Val Leu Thr Asp Ala Ser His 
        835                 840                 845


Thr Lys Cys Leu Cys Asp Arg Leu Ser Thr Phe Ala Ile Leu Ala Gln 
    850                 855                 860


Gln Pro Arg Glu Ile Ile Met Glu Ser Ser Gly Thr Pro Ser Val Thr 
865                 870                 875                 880


Leu Ile Val Gly Ser Gly Leu Ser Cys Leu Ala Leu Ile Thr Leu Ala 
                885                 890                 895


Val Val Tyr Ala Ala Leu Trp Arg Tyr Ile Arg Ser Glu Arg Ser Ile 
            900                 905                 910


Ile Leu Ile Asn Phe Cys Leu Ser Ile Ile Ser Ser Asn Ile Leu Ile 
        915                 920                 925


Leu Val Gly Gln Thr Gln Thr His Asn Lys Ser Ile Cys Thr Thr Thr 
    930                 935                 940


Thr Ala Phe Leu His Phe Phe Phe Leu Ala Ser Phe Cys Trp Val Leu 
945                 950                 955                 960


Thr Glu Ala Trp Gln Ser Tyr Met Ala Val Thr Gly Lys Ile Arg Thr 
                965                 970                 975


Arg Leu Ile Arg Lys Arg Phe Leu Cys Leu Gly Trp Gly Leu Pro Ala 
            980                 985                 990


Leu Val Val Ala Thr Ser Val Gly Phe Thr Arg Thr Lys Gly Tyr Gly 
        995                 1000                1005


Thr Asp His Tyr Cys Trp Leu Ser Leu Glu Gly Gly Leu Leu Tyr Ala 
    1010                1015                1020


Phe Val Gly Pro Ala Ala Ala Val Val Leu Val Asn Met Val Ile Gly 
1025                1030                1035                1040


Ile Leu Val Phe Asn Lys Leu Val Ser Arg Asp Gly Ile Leu Asp Lys 
                1045                1050                1055


Lys Leu Lys His Arg Ala Gly Gln Met Ser Glu Pro His Ser Gly Leu 
            1060                1065                1070


Thr Leu Lys Cys Ala Lys Cys Gly Val Val Ser Thr Thr Ala Leu Ser 
        1075                1080                1085


Ala Thr Thr Ala Ser Asn Ala Met Ala Ser Leu Trp Ser Ser Cys Val 
    1090                1095                1100


Val Leu Pro Leu Leu Ala Leu Thr Trp Met Ser Ala Val Leu Ala Met 
1105                1110                1115                1120


Thr Asp Lys Arg Ser Ile Leu Phe Gln Ile Leu Phe Ala Val Phe Asp 
                1125                1130                1135


Ser Leu Gln Gly Phe Val Ile Val Met Val His Cys Ile Leu Arg Arg 
            1140                1145                1150


Glu Val Gln Asp Ala Phe Arg Cys Arg Leu Arg Asn Cys Gln Asp Pro 
        1155                1160                1165


Ile Asn Ala Asp Ser Ser Ser Ser Phe Pro Asn Gly His Ala Gln Ile 
    1170                1175                1180


Met Thr Asp Phe Glu Lys Asp Val Asp Ile Ala Cys Arg Ser Val Leu 
1185                1190                1195                1200


His Lys Asp Ile Gly Pro Cys Arg Ala Ala Thr Ile Thr Gly Thr Leu 
                1205                1210                1215


Ser Arg Ile Ser Leu Asn Asp Asp Glu Glu Glu Lys Gly Thr Asn Pro 
            1220                1225                1230


Glu Gly Leu Ser Tyr Ser Thr Leu Pro Gly Asn Val Ile Ser Lys Val 
        1235                1240                1245


Ile Ile Gln Gln Pro Thr Gly Leu His Met Pro Met Ser Met Asn Glu 
    1250                1255                1260


Leu Ser Asn Pro Cys Leu Lys Lys Glu Asn Ser Glu Leu Arg Arg Thr 
1265                1270                1275                1280


Val Tyr Leu Cys Thr Asp Asp Asn Leu Arg Gly Ala Asp Met Asp Ile 
                1285                1290                1295


Val His Pro Gln Glu Arg Met Met Glu Ser Asp Tyr Ile Val Met Pro 
            1300                1305                1310


Arg Ser Ser Val Asn Asn Gln Pro Ser Met Lys Glu Glu Ser Lys Met 
        1315                1320                1325


Asn Ile Gly Met Glu Thr Leu Pro His Glu Arg Leu Leu His Tyr Lys 
    1330                1335                1340


Val Asn Pro Glu Phe Asn Met Asn Pro Pro Val Met Asp Gln Phe Asn 
1345                1350                1355                1360


Met Asn Leu Glu Gln His Leu Ala Pro Gln Glu His Met Gln Asn Leu 
                1365                1370                1375


Pro Phe Glu Pro Arg Thr Ala Val Lys Asn Phe Met Ala Ser Glu Leu 
            1380                1385                1390


Asp Asp Asn Ala Gly Leu Ser Arg Ser Glu Thr Gly Ser Thr Ile Ser 
        1395                1400                1405


Met Ser Ser Leu Glu Arg Arg Lys Ser Arg Tyr Ser Asp Leu Asp Phe 
    1410                1415                1420


Glu Lys Val Met His Thr Arg Lys Arg His Met Glu Leu Phe Gln Glu 
1425                1430                1435                1440


Leu Asn Gln Lys Phe Gln Thr Leu Asp Arg Phe Arg Asp Ile Pro Asn 
                1445                1450                1455


Thr Ser Ser Met Glu Asn Pro Ala Pro Asn Lys Asn Pro Trp Asp Thr 
            1460                1465                1470


Phe Lys Asn Pro Ser Glu Tyr Pro His Tyr Thr Thr Ile Asn Val Leu 
        1475                1480                1485


Asp Thr Glu Ala Lys Asp Ala Leu Glu Leu Arg Pro Ala Glu Trp Glu 
    1490                1495                1500


Lys Cys Leu Asn Leu Pro Leu Asp Val Gln Glu Gly Asp Phe Gln Thr 
1505                1510                1515                1520


Glu Val 



<210>  3278
<211>  6058
<212>  DNA
<213>  Homo sapiens

<400>  3278
actatctcgc tccctctcgc gcctccctcc tcgctgggca ttcaaacagc tttccgacat     60

caccagccaa ggattttttt ccccgctctc cttagtcgcc gtccgtccat cagtacctgc    120

aggggggagg aggaggaggg aggaaagcgg aaagaggaaa aagcataagc ttgagccttc    180

cgatccgacc acgaatactc ctgtaataaa cccaccgccc caacaaatct gccatagcag    240

ccgccgccgc cgccggtcac ttctcgtctc agcgctttct ttgcttcttg gtttgttggg    300

ggtagctttt atgaaacaaa tctttgctat taagccactt acattttggg gggttcctta    360

gagtctccct tgggggggct tctccctccc tttagccccc ctcggtttgg aggttggatt    420

cagttggata cggcgcaagg ttctgggctc ctgctggctt ttttttcctc tctctcatcg    480

accccccttt ggttcccacc ccccaccttt tgcttttcgt atgtatgcat ttttaaaaat    540

aaatcctgat tttggaagct gagccgggga aaatgggcaa cggtgattgg gaccgaaggg    600

gagtctctcc gtcactgttg ctgggacgcg tgcctgtgct ggtgtcttag agcaagagcc    660

tccctgagct ttcggagtgg aagaacagtg gaagagactg cagcctaaag acttttaaaa    720

ttaacttggc atcactttta tcagctcaaa ggctaaacaa acaaacaaaa gcagtgtcat    780

ttattctaag aaataacttc ttaaaggtta aagctgaaaa atattcaagt tatttttgga    840

taacaactta cagaggccaa atgacatagg atgaaggctg ttcgtaacct gctgatttat    900

atattttcca cctatctcct ggttatgttt ggatttaatg ctgcccaaga cttctggtgt    960

tcaactttgg tgaagggagt catttatgga tcgtattctg taagtgaaat gtttcctaaa   1020

aactttacaa actgcacttg gacgctggaa aatccagatc caaccaaata tagcatttac   1080

ctgaaatttt ccaaaaagga ccttagctgc tctaactttt cactcctggc ttatcagttt   1140

gatcattttt cccatgaaaa aataaaggat cttttaagaa agaatcattc tataatgcaa   1200

ctctgcaatt ccaagaatgc tttcgttttt ctacagtatg ataaaaattt tattcaaata   1260

cgtcgagtat ttccaactaa tttcccagga ttacagaaaa aaggggaaga agatcagaaa   1320

tctttttttg agtttttggt attgaacaag gtcagcccaa gccagtttgg ttgccatgta   1380

ttatgtactt ggttggagag ctgcttaaaa tcagaaaatg ggagaacaga atcatgtggg   1440

atcatgtata caaaatgcac ctgccctcag catttgggag agtgggggat cgacgaccag   1500

tcgctgattt tgttaaataa cgtggtgtta cccctgaatg agcagacaga gggctgcctg   1560

acccaggagc tgcaaaccac ccaagtctgc aatcttacca gggaggccaa gcgaccaccc   1620

aaagaagaat ttggaatgat gggagatcat acaattaaaa gtcagcgacc tcgatctgtt   1680

catgaaaaaa gggtccctca ggaacaagct gatgctgcta aatttatggc acaaactggt   1740

gaatctggtg tggaagagtg gtcccagtgg agcacatgtt cggttacttg tggtcaaggg   1800

tcgcaggtgc gaaccagaac ttgtgtatca ccttacggga cacactgcag cggcccatta   1860

agagaatcaa gggtttgcaa taacactgcc ctctgtccag tacacggagt atgggaggaa   1920

tggtcaccat ggagtttatg ttcatttaca tgtggtcgag gccaaagaac aagaacaagg   1980

tcatgcacac ctcctcagta tggaggaagg ccgtgtgaag gacctgaaac acatcataag   2040

ccttgtaata ttgctctttg cccagttgat ggacagtggc aagagtggag ttcgtggagc   2100

cagtgctcag taacgtgctc gaatgggact cagcagagaa gccggcagtg cactgcagct   2160

gcccatggag gctccgaatg cagagggcca tgggcagaaa gcagagagtg ctataaccct   2220

gaatgtacag ccaatggtca atggaatcag tggggtcatt ggagtggttg ttccaagtcc   2280

tgtgatggcg gctgggaaag gcgaataagg acctgtcagg gtgcagtgat aacagggcag   2340

caatgtgaag gaacgggcga agaagtgaga agatgcaatg agcagcgatg ccctgcacct   2400

tatgaaatat gccctgagga ttatctgatg tcgatggtgt ggaaaagaac tccagcaggc   2460

gacttggcat tcaatcaatg tcccctgaat gccacaggca ccactagcag acgctgctct   2520

ctcagtcttc atggagtggc cttctgggaa cagccgagct ttgcaagatg catatcaaat   2580

gagtacagac acttgcagca ttcaattaaa gagcaccttg ctaaggggca gcgaatgctg   2640

gcaggtgatg gaatgtccca ggtgaccaag acactgttgg atttaactca gagaaaaaat   2700

ttctatgcag gcgatcttct gatgtctgtg gagatcctga gaaatgtgac agacacattt   2760

aaaagggcaa gttacatccc tgcatctgat ggtgtccaga acttctttca aatagttagc   2820

aaccttctag atgaagaaaa caaggaaaaa tgggaagatg cacaacagat ttatccaggg   2880

tcaatagagt taatgcaggt gattgaagat tttatacaca ttgttggaat ggggatgatg   2940

gactttcaga attcatactt aatgactgga aatgtagtgg ctagtattca gaagcttcct   3000

gcagcctctg ttctaacaga catcaacttt ccaatgaaag gacggaaggg aatggttgac   3060

tgggcaagaa actcagaaga tagggtagta attccaaaaa gcattttcac tccggtgtca   3120

tcaaaagaat tagatgaatc atctgtattt gttcttggcg cagtcctata caaaaactta   3180

gatctaattt tgcccacttt gagaaattat actgtcatta attccaaaat catcgtggtc   3240

acaataaggc ctgaacccaa aacaaccgat tcgtttctgg agatagaact agctcatttg   3300

gctaatggta ctttgaatcc ctattgtgta ttgtgggatg actccaaaac gaacgagtct   3360

ttgggaacgt ggtccaccca gggatgtaaa actgtgctta ccgatgcatc ccatacgaaa   3420

tgcttatgtg atcgtctctc taccttcgcc attttggctc agcaacctag agaaataatc   3480

atggaatcct ctggcacacc ttcagttacc ctaatagtag gcagtggtct ttcttgcttg   3540

gccttgatta ccctagcagt tgtctatgca gcattatgga ggtacatacg ctctgagaga   3600

tccataatac taattaactt ctgcctgtct atcatctcat ccaatatcct catactggtt   3660

ggacagactc agacacataa taagagtatc tgcacaacca ccactgcatt tttgcacttt   3720

ttcttcctgg cttcattctg ttgggttttg actgaggcgt ggcaatcata tatggctgta   3780

actggaaaaa ttaggacacg gcttataaga aaacgctttt tgtgccttgg atggggttta   3840

ccagcattag tagtggccac atcagtaggc ttcaccagaa caaaaggata tggcactgat   3900

cactactgct ggctctctct tgaaggagga ctactctatg cttttgtggg acctgcagcc   3960

gctgttgtcc tggtcaacat ggtgattggc attttggtat ttaataaact tgtttccaga   4020

gatggaatcc tagataaaaa gctcaaacac agagccggtc agatgagtga gcctcatagc   4080

ggtttgacgc tcaaatgtgc caagtgtgga gtagtttcaa caacagcttt gtcagccacc   4140

accgccagta acgccatggc gtctctttgg agctcctgtg tggtgttgcc ccttctggct   4200

ttgacgtgga tgtctgcggt tctggccatg acagataaac gctccatatt gtttcaaata   4260

ctttttgctg tgtttgattc attgcaaggc tttgttatag tcatggtcca ctgcattctt   4320

cggagagagg ttcaggatgc atttagatgc cgattgagaa actgtcagga tcccatcaat   4380

gcagattctt cgagttcgtt tcctaatggg catgctcaaa tcatgacaga ctttgaaaag   4440

gatgtagaca ttgcctgtcg atcagttctt cataaggata ttggtccttg ccgagcagcc   4500

acaataacag gaacactttc taggatttct ctaaatgatg atgaagaaga aaagggaaca   4560

aaccctgaag ggctaagcta ttcaacattg cctggaaatg tcatttccaa agtcatcatc   4620

cagcaaccca caggtttgca catgcccatg agtatgaatg agcttagcaa tccatgtttg   4680

aaaaaagaaa atagtgaatt gcggagaact gtgtacttat gtacggatga taatttgaga   4740

ggggctgaca tggacatagt ccatcctcaa gaaagaatga tggaaagtga ctatattgtg   4800

atgcccagaa gttctgtaaa taaccagcct tcaatgaaag aagaaagcaa aatgaatatt   4860

ggcatggaaa ccttgccgca tgaaaggcta ttgcactaca aagtaaaccc tgaattcaat   4920

atgaatcccc ctgtaatgga ccagttcaat atgaacttag agcaacatct cgcaccccag   4980

gaacatatgc agaatttgcc ctttgaacct cgcacagctg tgaagaattt catggcctct   5040

gagttggatg ataatgcagg actatcaaga agtgaaactg gatcaacgat atcaatgagt   5100

tctttagaga gaagaaaatc acgatattca gaccttgact ttgagaaggt catgcataca   5160

aggaagaggc atatggaact atttcaagaa ctaaatcaga aatttcaaac tttggacaga   5220

tttcgggata taccaaatac aagcagtatg gaaaaccccg caccaaacaa gaatccatgg   5280

gacactttca aaaaccccag tgaatacccg cattacacca caatcaatgt cttagacaca   5340

gaggcaaagg atgctttgga actgaggcca gcagagtggg agaagtgtct gaatttgcct   5400

ctggatgtgc aagagggtga ctttcaaaca gaagtttaaa aaaatcaaaa tggactaagg   5460

tagagacaaa actttattgc actgacactt aagacttggg aagcctgaca tttctatctg   5520

gacagtgtga ctatcttatg tcaggacctt catgtgccaa acgtcagtgg tgttttcata   5580

tggtaacttc tcactagtca ggctagtgga gagatgacca ggtgtacagt tctgaccatc   5640

ctgtgttgta agtacccgtg gaatggattt gtaaggtaat ctttatagat aaacctcaag   5700

caacgattca tgttgtaacc gcttcatatg gtttagtttt caaaaaactt caccatgaag   5760

cacaatgtat atatttatgc agtttttaaa gtttataaca gtctgtttgg ccattactac   5820

actttttact ttataatata aaagcaaagt ttttgtcatt aaatgaatgt ttgttgagct   5880

acattcttca ttgctttaaa tgcaataaag taataatctc acttttatat gaataatata   5940

tttcacatct ttattattgc agttttctct agaaagctct gagaagcttt ctctgctgca   6000

gctgtgtata aaatatttaa aatgttgtat ggtgtaaata aacttttgtc tacatatc     6058


<210>  3279
<211>  1522
<212>  PRT
<213>  Homo sapiens

<400>  3279

Met Lys Ala Val Arg Asn Leu Leu Ile Tyr Ile Phe Ser Thr Tyr Leu 
1               5                   10                  15


Leu Val Met Phe Gly Phe Asn Ala Ala Gln Asp Phe Trp Cys Ser Thr 
            20                  25                  30


Leu Val Lys Gly Val Ile Tyr Gly Ser Tyr Ser Val Ser Glu Met Phe 
        35                  40                  45


Pro Lys Asn Phe Thr Asn Cys Thr Trp Thr Leu Glu Asn Pro Asp Pro 
    50                  55                  60


Thr Lys Tyr Ser Ile Tyr Leu Lys Phe Ser Lys Lys Asp Leu Ser Cys 
65                  70                  75                  80


Ser Asn Phe Ser Leu Leu Ala Tyr Gln Phe Asp His Phe Ser His Glu 
                85                  90                  95


Lys Ile Lys Asp Leu Leu Arg Lys Asn His Ser Ile Met Gln Leu Cys 
            100                 105                 110


Asn Ser Lys Asn Ala Phe Val Phe Leu Gln Tyr Asp Lys Asn Phe Ile 
        115                 120                 125


Gln Ile Arg Arg Val Phe Pro Thr Asn Phe Pro Gly Leu Gln Lys Lys 
    130                 135                 140


Gly Glu Glu Asp Gln Lys Ser Phe Phe Glu Phe Leu Val Leu Asn Lys 
145                 150                 155                 160


Val Ser Pro Ser Gln Phe Gly Cys His Val Leu Cys Thr Trp Leu Glu 
                165                 170                 175


Ser Cys Leu Lys Ser Glu Asn Gly Arg Thr Glu Ser Cys Gly Ile Met 
            180                 185                 190


Tyr Thr Lys Cys Thr Cys Pro Gln His Leu Gly Glu Trp Gly Ile Asp 
        195                 200                 205


Asp Gln Ser Leu Ile Leu Leu Asn Asn Val Val Leu Pro Leu Asn Glu 
    210                 215                 220


Gln Thr Glu Gly Cys Leu Thr Gln Glu Leu Gln Thr Thr Gln Val Cys 
225                 230                 235                 240


Asn Leu Thr Arg Glu Ala Lys Arg Pro Pro Lys Glu Glu Phe Gly Met 
                245                 250                 255


Met Gly Asp His Thr Ile Lys Ser Gln Arg Pro Arg Ser Val His Glu 
            260                 265                 270


Lys Arg Val Pro Gln Glu Gln Ala Asp Ala Ala Lys Phe Met Ala Gln 
        275                 280                 285


Thr Gly Glu Ser Gly Val Glu Glu Trp Ser Gln Trp Ser Thr Cys Ser 
    290                 295                 300


Val Thr Cys Gly Gln Gly Ser Gln Val Arg Thr Arg Thr Cys Val Ser 
305                 310                 315                 320


Pro Tyr Gly Thr His Cys Ser Gly Pro Leu Arg Glu Ser Arg Val Cys 
                325                 330                 335


Asn Asn Thr Ala Leu Cys Pro Val His Gly Val Trp Glu Glu Trp Ser 
            340                 345                 350


Pro Trp Ser Leu Cys Ser Phe Thr Cys Gly Arg Gly Gln Arg Thr Arg 
        355                 360                 365


Thr Arg Ser Cys Thr Pro Pro Gln Tyr Gly Gly Arg Pro Cys Glu Gly 
    370                 375                 380


Pro Glu Thr His His Lys Pro Cys Asn Ile Ala Leu Cys Pro Val Asp 
385                 390                 395                 400


Gly Gln Trp Gln Glu Trp Ser Ser Trp Ser Gln Cys Ser Val Thr Cys 
                405                 410                 415


Ser Asn Gly Thr Gln Gln Arg Ser Arg Gln Cys Thr Ala Ala Ala His 
            420                 425                 430


Gly Gly Ser Glu Cys Arg Gly Pro Trp Ala Glu Ser Arg Glu Cys Tyr 
        435                 440                 445


Asn Pro Glu Cys Thr Ala Asn Gly Gln Trp Asn Gln Trp Gly His Trp 
    450                 455                 460


Ser Gly Cys Ser Lys Ser Cys Asp Gly Gly Trp Glu Arg Arg Ile Arg 
465                 470                 475                 480


Thr Cys Gln Gly Ala Val Ile Thr Gly Gln Gln Cys Glu Gly Thr Gly 
                485                 490                 495


Glu Glu Val Arg Arg Cys Asn Glu Gln Arg Cys Pro Ala Pro Tyr Glu 
            500                 505                 510


Ile Cys Pro Glu Asp Tyr Leu Met Ser Met Val Trp Lys Arg Thr Pro 
        515                 520                 525


Ala Gly Asp Leu Ala Phe Asn Gln Cys Pro Leu Asn Ala Thr Gly Thr 
    530                 535                 540


Thr Ser Arg Arg Cys Ser Leu Ser Leu His Gly Val Ala Phe Trp Glu 
545                 550                 555                 560


Gln Pro Ser Phe Ala Arg Cys Ile Ser Asn Glu Tyr Arg His Leu Gln 
                565                 570                 575


His Ser Ile Lys Glu His Leu Ala Lys Gly Gln Arg Met Leu Ala Gly 
            580                 585                 590


Asp Gly Met Ser Gln Val Thr Lys Thr Leu Leu Asp Leu Thr Gln Arg 
        595                 600                 605


Lys Asn Phe Tyr Ala Gly Asp Leu Leu Met Ser Val Glu Ile Leu Arg 
    610                 615                 620


Asn Val Thr Asp Thr Phe Lys Arg Ala Ser Tyr Ile Pro Ala Ser Asp 
625                 630                 635                 640


Gly Val Gln Asn Phe Phe Gln Ile Val Ser Asn Leu Leu Asp Glu Glu 
                645                 650                 655


Asn Lys Glu Lys Trp Glu Asp Ala Gln Gln Ile Tyr Pro Gly Ser Ile 
            660                 665                 670


Glu Leu Met Gln Val Ile Glu Asp Phe Ile His Ile Val Gly Met Gly 
        675                 680                 685


Met Met Asp Phe Gln Asn Ser Tyr Leu Met Thr Gly Asn Val Val Ala 
    690                 695                 700


Ser Ile Gln Lys Leu Pro Ala Ala Ser Val Leu Thr Asp Ile Asn Phe 
705                 710                 715                 720


Pro Met Lys Gly Arg Lys Gly Met Val Asp Trp Ala Arg Asn Ser Glu 
                725                 730                 735


Asp Arg Val Val Ile Pro Lys Ser Ile Phe Thr Pro Val Ser Ser Lys 
            740                 745                 750


Glu Leu Asp Glu Ser Ser Val Phe Val Leu Gly Ala Val Leu Tyr Lys 
        755                 760                 765


Asn Leu Asp Leu Ile Leu Pro Thr Leu Arg Asn Tyr Thr Val Ile Asn 
    770                 775                 780


Ser Lys Ile Ile Val Val Thr Ile Arg Pro Glu Pro Lys Thr Thr Asp 
785                 790                 795                 800


Ser Phe Leu Glu Ile Glu Leu Ala His Leu Ala Asn Gly Thr Leu Asn 
                805                 810                 815


Pro Tyr Cys Val Leu Trp Asp Asp Ser Lys Thr Asn Glu Ser Leu Gly 
            820                 825                 830


Thr Trp Ser Thr Gln Gly Cys Lys Thr Val Leu Thr Asp Ala Ser His 
        835                 840                 845


Thr Lys Cys Leu Cys Asp Arg Leu Ser Thr Phe Ala Ile Leu Ala Gln 
    850                 855                 860


Gln Pro Arg Glu Ile Ile Met Glu Ser Ser Gly Thr Pro Ser Val Thr 
865                 870                 875                 880


Leu Ile Val Gly Ser Gly Leu Ser Cys Leu Ala Leu Ile Thr Leu Ala 
                885                 890                 895


Val Val Tyr Ala Ala Leu Trp Arg Tyr Ile Arg Ser Glu Arg Ser Ile 
            900                 905                 910


Ile Leu Ile Asn Phe Cys Leu Ser Ile Ile Ser Ser Asn Ile Leu Ile 
        915                 920                 925


Leu Val Gly Gln Thr Gln Thr His Asn Lys Ser Ile Cys Thr Thr Thr 
    930                 935                 940


Thr Ala Phe Leu His Phe Phe Phe Leu Ala Ser Phe Cys Trp Val Leu 
945                 950                 955                 960


Thr Glu Ala Trp Gln Ser Tyr Met Ala Val Thr Gly Lys Ile Arg Thr 
                965                 970                 975


Arg Leu Ile Arg Lys Arg Phe Leu Cys Leu Gly Trp Gly Leu Pro Ala 
            980                 985                 990


Leu Val Val Ala Thr Ser Val Gly Phe Thr Arg Thr Lys Gly Tyr Gly 
        995                 1000                1005


Thr Asp His Tyr Cys Trp Leu Ser Leu Glu Gly Gly Leu Leu Tyr Ala 
    1010                1015                1020


Phe Val Gly Pro Ala Ala Ala Val Val Leu Val Asn Met Val Ile Gly 
1025                1030                1035                1040


Ile Leu Val Phe Asn Lys Leu Val Ser Arg Asp Gly Ile Leu Asp Lys 
                1045                1050                1055


Lys Leu Lys His Arg Ala Gly Gln Met Ser Glu Pro His Ser Gly Leu 
            1060                1065                1070


Thr Leu Lys Cys Ala Lys Cys Gly Val Val Ser Thr Thr Ala Leu Ser 
        1075                1080                1085


Ala Thr Thr Ala Ser Asn Ala Met Ala Ser Leu Trp Ser Ser Cys Val 
    1090                1095                1100


Val Leu Pro Leu Leu Ala Leu Thr Trp Met Ser Ala Val Leu Ala Met 
1105                1110                1115                1120


Thr Asp Lys Arg Ser Ile Leu Phe Gln Ile Leu Phe Ala Val Phe Asp 
                1125                1130                1135


Ser Leu Gln Gly Phe Val Ile Val Met Val His Cys Ile Leu Arg Arg 
            1140                1145                1150


Glu Val Gln Asp Ala Phe Arg Cys Arg Leu Arg Asn Cys Gln Asp Pro 
        1155                1160                1165


Ile Asn Ala Asp Ser Ser Ser Ser Phe Pro Asn Gly His Ala Gln Ile 
    1170                1175                1180


Met Thr Asp Phe Glu Lys Asp Val Asp Ile Ala Cys Arg Ser Val Leu 
1185                1190                1195                1200


His Lys Asp Ile Gly Pro Cys Arg Ala Ala Thr Ile Thr Gly Thr Leu 
                1205                1210                1215


Ser Arg Ile Ser Leu Asn Asp Asp Glu Glu Glu Lys Gly Thr Asn Pro 
            1220                1225                1230


Glu Gly Leu Ser Tyr Ser Thr Leu Pro Gly Asn Val Ile Ser Lys Val 
        1235                1240                1245


Ile Ile Gln Gln Pro Thr Gly Leu His Met Pro Met Ser Met Asn Glu 
    1250                1255                1260


Leu Ser Asn Pro Cys Leu Lys Lys Glu Asn Ser Glu Leu Arg Arg Thr 
1265                1270                1275                1280


Val Tyr Leu Cys Thr Asp Asp Asn Leu Arg Gly Ala Asp Met Asp Ile 
                1285                1290                1295


Val His Pro Gln Glu Arg Met Met Glu Ser Asp Tyr Ile Val Met Pro 
            1300                1305                1310


Arg Ser Ser Val Asn Asn Gln Pro Ser Met Lys Glu Glu Ser Lys Met 
        1315                1320                1325


Asn Ile Gly Met Glu Thr Leu Pro His Glu Arg Leu Leu His Tyr Lys 
    1330                1335                1340


Val Asn Pro Glu Phe Asn Met Asn Pro Pro Val Met Asp Gln Phe Asn 
1345                1350                1355                1360


Met Asn Leu Glu Gln His Leu Ala Pro Gln Glu His Met Gln Asn Leu 
                1365                1370                1375


Pro Phe Glu Pro Arg Thr Ala Val Lys Asn Phe Met Ala Ser Glu Leu 
            1380                1385                1390


Asp Asp Asn Ala Gly Leu Ser Arg Ser Glu Thr Gly Ser Thr Ile Ser 
        1395                1400                1405


Met Ser Ser Leu Glu Arg Arg Lys Ser Arg Tyr Ser Asp Leu Asp Phe 
    1410                1415                1420


Glu Lys Val Met His Thr Arg Lys Arg His Met Glu Leu Phe Gln Glu 
1425                1430                1435                1440


Leu Asn Gln Lys Phe Gln Thr Leu Asp Arg Phe Arg Asp Ile Pro Asn 
                1445                1450                1455


Thr Ser Ser Met Glu Asn Pro Ala Pro Asn Lys Asn Pro Trp Asp Thr 
            1460                1465                1470


Phe Lys Asn Pro Ser Glu Tyr Pro His Tyr Thr Thr Ile Asn Val Leu 
        1475                1480                1485


Asp Thr Glu Ala Lys Asp Ala Leu Glu Leu Arg Pro Ala Glu Trp Glu 
    1490                1495                1500


Lys Cys Leu Asn Leu Pro Leu Asp Val Gln Glu Gly Asp Phe Gln Thr 
1505                1510                1515                1520


Glu Val 



<210>  3280
<211>  510
<212>  DNA
<213>  Homo sapiens

<400>  3280
gtcctgcact ctcttcttcc cacggttacc ataagaatcc cactgaattt atgggaaaca     60

ctcgcctgac ttctccatgc tgctgtagac agtgacacac acagggtgga aggaagttgt    120

ttctgctgtt acctttcaga gtcttaagtc ctcttgtcca atatccgtgt ggtagcccct    180

gtaagcattt gggtttgtga tccctgatat ccagttcctt ttcagctttg tcattcaatg    240

atgctttttt gcccatctgt cctaagctta gcctattgtt ccactcttct gggcttcgtc    300

ttctatccct tgagtgcagg tttcctcttc caggacactt ctcctccact tgtactgctg    360

cttattaaag tgaaagtgag cacatacata gcatttagga atccatgtcc ccagcagtcc    420

atgtggtcag tgatattagc tatgtgctgg catttcatgt atatgtcact ggaaacttat    480

cactttaata atcacaaatc ttcagtcttg                                     510


<210>  3281
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  3281

Met Met Leu Phe Cys Pro Ser Val Leu Ser Leu Ala Tyr Cys Ser Thr 
1               5                   10                  15


Leu Leu Gly Phe Val Phe Tyr Pro Leu Ser Ala Gly Phe Leu Phe Gln 
            20                  25                  30


Asp Thr Ser Pro Pro Leu Val Leu Leu Leu Ile Lys Val Lys Val Ser 
        35                  40                  45


Thr Tyr Ile Ala Phe Arg Asn Pro Cys Pro Gln Gln Ser Met Trp Ser 
    50                  55                  60


Val Ile Leu Ala Met Cys Trp His Phe Met Tyr Met Ser Leu Glu Thr 
65                  70                  75                  80


Tyr His Phe Asn Asn His Lys Ser Ser Val 
                85                  90


<210>  3282
<211>  1147
<212>  DNA
<213>  Homo sapiens

<400>  3282
gtaatataca catgtatgga acaaggagaa actattatca caatggacta taatatagtt     60

tctgactccc tgtaaataga atctgctcta aattaagcag atgctatagc catgcttcaa    120

tataactctg ttttcaactt cgttatgaaa tcctttaagg gtgaggccat tttacaaagg    180

acaaagaaac tggtgcttca ggaactaaac ttttttggat gaaacccaaa tgtatctggc    240

atatcttgaa ttgtctttta tagtcaatcc tgttttaggg acattaacaa aggtttatta    300

ttacataatt tgagagtctt tcaaataaaa ggaaagggca gatcaagggc cattttcccc    360

aacctcagga gttaactcct cagtacctca caggaacctg aaatctttgg aggaaaaaaa    420

aatagtatta ttttaaaaat taaaaataat aaagatggct ctctaaagaa acatctgaaa    480

ttagtagtaa catgctgtaa tattattttc cattgactgt agccaagggc ctctgctagc    540

acccatgaga actttgtgtt cttgagaata agacaccttt gctccagggc ttagtgagca    600

gggcctgaac tggagttccc tcccaccacc ttaactgaac tcttcatgca ggacacagca    660

tgtacaacct cacatagagt tcctgaccag acaagacttg ctggaaattt cccaggatct    720

tccttcctta agaggaatca aaagaaggag gaagaataga atgatttgga ggaaaagaag    780

gagaaagtag aggagttgaa aaaaaggaag aaaaagaaaa atgcagaatc ctttgtcaat    840

ccaacagaac acagcaaaaa agcaaagaaa gtgaaagcat agatttgctt gtaagtagat    900

aatgcatcat gagcatcttc tctattgatg aaaatctttc ggtgttggga tctgtttata    960

actgcatcat cacaaacatg atctaatcaa gagtcactcc ttgcagtaat gttcacgttt   1020

ccttcgtctc tgaaaagata tccctctaga aaccctgttt ctactacaaa aattagctgg   1080

acgtggtggc gggcgtctgt aatcccagct actctggagg ccgaggcagg agaattgctc   1140

gaactca                                                             1147


<210>  3283
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  3283

Met Phe Thr Phe Pro Ser Ser Leu Lys Arg Tyr Pro Ser Arg Asn Pro 
1               5                   10                  15


Val Ser Thr Thr Lys Ile Ser Trp Thr Trp Trp Arg Ala Ser Val Ile 
            20                  25                  30


Pro Ala Thr Leu Glu Ala Glu Ala Gly Glu Leu Leu Glu 
        35                  40                  45


<210>  3284
<211>  467
<212>  DNA
<213>  Homo sapiens

<400>  3284
aatccttcca agaaactcac aaagcagggc tttttcttga acttctcttc ctcacaacag     60

ttaaatcatc catttaaaga tgtcaaacaa cctccgtgtt ctaagatgtc tctgtgttag    120

gaaaacttgg ataagcaggt ccatagaaat tcctctgcta gccctgtctc ctggaatttc    180

tacataatgg catatcctca gtttgaagct gaaaaggtta aattctacct gaaggatgaa    240

aacaaccaac attctgtgcc aagacagtca ggagggcaac catgtttcct ggtggagcct    300

ctggaaccac tcaagccaag atgaccgggg gtttggctgg gaggagatgg ggaaactaca    360

gaccctacag atggtttcct gtaccatgag gttaagcctg ggggcaggag aggctgtacc    420

ttagttcctt catctgtaaa ataaagtaac atagtaccta cctcata                  467


<210>  3285
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  3285

Met Ala Tyr Pro Gln Phe Glu Ala Glu Lys Val Lys Phe Tyr Leu Lys 
1               5                   10                  15


Asp Glu Asn Asn Gln His Ser Val Pro Arg Gln Ser Gly Gly Gln Pro 
            20                  25                  30


Cys Phe Leu Val Glu Pro Leu Glu Pro Leu Lys Pro Arg 
        35                  40                  45


<210>  3286
<211>  412
<212>  DNA
<213>  Homo sapiens

<400>  3286
ttaaatcatc catttaaaga tgtcaaacaa cctccgtgtt ctaaggacac agcatgtaca     60

acctcacata gagttcctga ccagacaaga cttgctggaa atttcccagg atcttccttc    120

cttaagtttg aatagctctc tggttccagt ttgaagctga aaaggttaaa ttctacctga    180

aggatgaaaa caaccaacat tctgtgccaa gacagtcagg agggcaacca tgtttcctgg    240

tggagcctct ggaaccactc aagccaagat gaccgggggt ttggctggga ggagatgggg    300

aaactacaga ccctacagat ggtttcctgt accatgaggt taagcctggg ggcaggagag    360

gctgtacctt agttccttca tctgtaaaat aaagtaacat agtacctacc tc            412


<210>  3287
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  3287

Met Ser Asn Asn Leu Arg Val Leu Arg Thr Gln His Val Gln Pro His 
1               5                   10                  15


Ile Glu Phe Leu Thr Arg Gln Asp Leu Leu Glu Ile Ser Gln Asp Leu 
            20                  25                  30


Pro Ser Leu Ser Leu Asn Ser Ser Leu Val Pro Val 
        35                  40


<210>  3288
<211>  522
<212>  DNA
<213>  Homo sapiens

<400>  3288
atggtgcccg gcaccatcag cttttgtcct ctgctgcagc taaagtgtct tcctcctgga     60

ccagggagag ggggaggggg tgtggacagg acccgcctgc tgacggtgac acctcttcga    120

caccacgtcc acgccagtcc tcagctccag gagctgggcg ggatccctca tcccgctcag    180

ctgggagatg ccccgggagg gcgtcccccg gctccgggcg gcgagggtag tagccgaccc    240

caatccactc cgggggccgc cgggggccgc gtgaaggcag gtgttccggg gagaaacgtg    300

gaagggaggc gcggcctggg gccggtggcg ctcggctggg ggccgcagtt ggctcccctg    360

ggggctctgg gcggcggcag ctcccgcctg tggggaggag aaggagccgg atgggcgggt    420

tcaggcgcgc gcggcggcgg tcccggggcc gccggctcct ccccgcgagg gtgcctgtcc    480

gccgctcgcc gcgctgaggc agtgcggggc gggcgcgcct ag                       522


<210>  3289
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  3289

Met Val Pro Gly Thr Ile Ser Phe Cys Pro Leu Leu Gln Leu Lys Cys 
1               5                   10                  15


Leu Pro Pro Gly Pro Gly Arg Gly Gly Gly Gly Val Asp Arg Thr Arg 
            20                  25                  30


Leu Leu Thr Val Thr Pro Leu Arg His His Val His Ala Ser Pro Gln 
        35                  40                  45


Leu Gln Glu Leu Gly Gly Ile Pro His Pro Ala Gln Leu Gly Asp Ala 
    50                  55                  60


Pro Gly Gly Arg Pro Pro Ala Pro Gly Gly Glu Gly Ser Ser Arg Pro 
65                  70                  75                  80


Gln Ser Thr Pro Gly Ala Ala Gly Gly Arg Val Lys Ala Gly Val Pro 
                85                  90                  95


Gly Arg Asn Val Glu Gly Arg Arg Gly Leu Gly Pro Val Ala Leu Gly 
            100                 105                 110


Trp Gly Pro Gln Leu Ala Pro Leu Gly Ala Leu Gly Gly Gly Ser Ser 
        115                 120                 125


Arg Leu Trp Gly Gly Glu Gly Ala Gly Trp Ala Gly Ser Gly Ala Arg 
    130                 135                 140


Gly Gly Gly Pro Gly Ala Ala Gly Ser Ser Pro Arg Gly Cys Leu Ser 
145                 150                 155                 160


Ala Ala Arg Arg Ala Glu Ala Val Arg Gly Gly Arg Ala 
                165                 170


<210>  3290
<211>  2094
<212>  DNA
<213>  Homo sapiens

<400>  3290
tcgacaccac gtccacgcca gtcctcagct ccaggagctg ggcgggatcc ctcatcccgc     60

tcagctggga gatgccccgg gagggcgtcc cccggctccg ggcggcgagg gtagtagccg    120

accccaatcc actccggggg ccgccggggg ccgcgtgaag gcaggtgttc cggggagaaa    180

cgtggaaggg aggcgcggcc tggggccggt ggcgctcggc tgggggccgc agttggctcc    240

cctgggggct ctgggcggcg gcagctcccg cctgtgggga ggagaaggag ccggatgggc    300

gggttcaggc gcgcgcggcg gcggtcccgg ggccgccggc tcctccccgc gagggtgcct    360

gtccgccgct cgccgcgctg aggcagtgcg gggcgggcgc gcctaggctg ccgcccagcg    420

ccctcgccgc ggccatgccc gggccctaga gcgcctgccg cagcttgcgc cccgcagccc    480

cgcagccccg cgcccgccgc cgcctcttca atgggcaacc tgctcggcgg ggtcagcttc    540

cgcgagccca ccaccgtgga ggactgcgac tccacctggc agaccgactc ggagcccgag    600

cccgaagaac cagggccggg cggcggcagc gagggcccgg ggcaggagtc cgagcagccc    660

gcgcagcccc cggagcaagc cggcgggcgg cccggcgcca gccccgcgcc ggacgaggac    720

gccgaggcgg cgggcgccga gcagggtggt gattccactg aagcaactgc caaaccaaag    780

agaagttttt atgctgccag ggatttgtac aagtaccgac accagtaccc aaacttcaaa    840

gatatccgat atcaaaatga cttgagcaat cttcgttttt ataagaataa aattccattc    900

aagccagatg gtgtttacat tgaagaagtt ctaagtaaat ggaaaggaga ttatgaaaaa    960

ctggagcaca accacactta cattcaatgg cttttccccc tgagagaaca aggcttgaac   1020

ttctatgcca aagaactaac tacatatgaa attgaggaat tcaaaaaaac aaaagaagca   1080

attagaagat tcctcctggc ttataaaatg atgctagaat tttttggaat aaaactgact   1140

gataaaactg gaaatgttgc tcgggctgtt aactggcagg aaagatttca gcatctgaat   1200

gagtcccagc acaactattt aagaatcact cgtattctta aaagccttgg tgagcttgga   1260

tatgaaagtt ttaaatctcc tcttgtaaaa tttattcttc atgaagctct tgtggagaat   1320

actattccca atattaagca gagtgctcta gagtattttg tttatacaat tagagacaga   1380

agagaaagga gaaagctcct gcggttcgcc cagaaacact acacgccttc agagaacttt   1440

atctggggac cgcctcgaaa agaacagtcg gagggaagca aagcccagaa aatgtcttcc   1500

cctctcgcct ccagtcataa cagtcaaact tctatgcaca aaaaagccaa ggactccaaa   1560

aattcctcct cagctgttca tttaaatagc aaaacagctg aagacaaaaa agtggcacca   1620

aaagagcctg tggaagagac agacaggccc agcccagagc ccagcaatga agctgccaag   1680

ccaagaaata cagagaagga cagtaatgct gagaacatga attctcaacc tgagaaaaca   1740

gttactactc ccacagaaaa aaaggagagt gtatctcctg agaataacga agaaggtgga   1800

aatgataacc aagacaatga aaatcctgga aatacaaatt gccatgatgt tgtactagta   1860

cagtgaatta tcagaaaacc cagaagccag tttaggctag agaggaaaaa actactgtat   1920

catttatcct aaagaacaga gatgaggtca atttcaaatt ttagccatct gtttgtgatt   1980

tctgtcataa gcattttgtt gtttgttttt ttattttgga tgacaatgaa ttgaatatct   2040

aataaggaga tttaagataa gacccaataa atgaatgtat tctgtaatgc tttt         2094


<210>  3291
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  3291

Met Gly Asn Leu Leu Gly Gly Val Ser Phe Arg Glu Pro Thr Thr Val 
1               5                   10                  15


Glu Asp Cys Asp Ser Thr Trp Gln Thr Asp Ser Glu Pro Glu Pro Glu 
            20                  25                  30


Glu Pro Gly Pro Gly Gly Gly Ser Glu Gly Pro Gly Gln Glu Ser Glu 
        35                  40                  45


Gln Pro Ala Gln Pro Pro Glu Gln Ala Gly Gly Arg Pro Gly Ala Ser 
    50                  55                  60


Pro Ala Pro Asp Glu Asp Ala Glu Ala Ala Gly Ala Glu Gln Gly Gly 
65                  70                  75                  80


Asp Ser Thr Glu Ala Thr Ala Lys Pro Lys Arg Ser Phe Tyr Ala Ala 
                85                  90                  95


Arg Asp Leu Tyr Lys Tyr Arg His Gln Tyr Pro Asn Phe Lys Asp Ile 
            100                 105                 110


Arg Tyr Gln Asn Asp Leu Ser Asn Leu Arg Phe Tyr Lys Asn Lys Ile 
        115                 120                 125


Pro Phe Lys Pro Asp Gly Val Tyr Ile Glu Glu Val Leu Ser Lys Trp 
    130                 135                 140


Lys Gly Asp Tyr Glu Lys Leu Glu His Asn His Thr Tyr Ile Gln Trp 
145                 150                 155                 160


Leu Phe Pro Leu Arg Glu Gln Gly Leu Asn Phe Tyr Ala Lys Glu Leu 
                165                 170                 175


Thr Thr Tyr Glu Ile Glu Glu Phe Lys Lys Thr Lys Glu Ala Ile Arg 
            180                 185                 190


Arg Phe Leu Leu Ala Tyr Lys Met Met Leu Glu Phe Phe Gly Ile Lys 
        195                 200                 205


Leu Thr Asp Lys Thr Gly Asn Val Ala Arg Ala Val Asn Trp Gln Glu 
    210                 215                 220


Arg Phe Gln His Leu Asn Glu Ser Gln His Asn Tyr Leu Arg Ile Thr 
225                 230                 235                 240


Arg Ile Leu Lys Ser Leu Gly Glu Leu Gly Tyr Glu Ser Phe Lys Ser 
                245                 250                 255


Pro Leu Val Lys Phe Ile Leu His Glu Ala Leu Val Glu Asn Thr Ile 
            260                 265                 270


Pro Asn Ile Lys Gln Ser Ala Leu Glu Tyr Phe Val Tyr Thr Ile Arg 
        275                 280                 285


Asp Arg Arg Glu Arg Arg Lys Leu Leu Arg Phe Ala Gln Lys His Tyr 
    290                 295                 300


Thr Pro Ser Glu Asn Phe Ile Trp Gly Pro Pro Arg Lys Glu Gln Ser 
305                 310                 315                 320


Glu Gly Ser Lys Ala Gln Lys Met Ser Ser Pro Leu Ala Ser Ser His 
                325                 330                 335


Asn Ser Gln Thr Ser Met His Lys Lys Ala Lys Asp Ser Lys Asn Ser 
            340                 345                 350


Ser Ser Ala Val His Leu Asn Ser Lys Thr Ala Glu Asp Lys Lys Val 
        355                 360                 365


Ala Pro Lys Glu Pro Val Glu Glu Thr Asp Arg Pro Ser Pro Glu Pro 
    370                 375                 380


Ser Asn Glu Ala Ala Lys Pro Arg Asn Thr Glu Lys Asp Ser Asn Ala 
385                 390                 395                 400


Glu Asn Met Asn Ser Gln Pro Glu Lys Thr Val Thr Thr Pro Thr Glu 
                405                 410                 415


Lys Lys Glu Ser Val Ser Pro Glu Asn Asn Glu Glu Gly Gly Asn Asp 
            420                 425                 430


Asn Gln Asp Asn Glu Asn Pro Gly Asn Thr Asn Cys His Asp Val Val 
        435                 440                 445


Leu Val Gln 
    450


<210>  3292
<211>  8761
<212>  DNA
<213>  Homo sapiens

<400>  3292
tcgacaccac gtccacgcca gtcctcagct ccaggagctg ggcgggatcc ctcatcccgc     60

tcagctggga gatgccccgg gagggcgtcc cccggctccg ggcggcgagg gtagtagccg    120

accccaatcc actccggggg ccgccggggg ccgcgtgaag gcaggtgttc cggggagaaa    180

cgtggaaggg aggcgcggcc tggggccggt ggcgctcggc tgggggccgc agttggctcc    240

cctgggggct ctgggcggcg gcagctcccg cctgtgggga ggagaaggag ccggatgggc    300

gggttcaggc gcgcgcggcg gcggtcccgg ggccgccggc tcctccccgc gagggtgcct    360

gtccgccgct cgccgcgctg aggcagtgcg gggcgggcgc gcctaggctg ccgcccagcg    420

ccctcgccgc ggccatgccc gggccctaga gcgcctgccg cagcttgcgc cccgcagccc    480

cgcagccccg cgcccgccgc cgcctcttca atgggcaacc tgctcggcgg ggtcagcttc    540

cgcgagccca ccaccgtgga ggactgcgac tccacctggc agaccgactc ggagcccgag    600

cccgaagaac cagggccggg cggcggcagc gagggcccgg ggcaggagtc cgagcagccc    660

gcgcagcccc cggagcaagc cggcgggcgg cccggcgcca gccccgcgcc ggacgaggac    720

gccgaggcgg cgggcgccga gcagggtggt gattccactg aagcaactgc caaaccaaag    780

agaagttttt atgctgccag ggatttgtac aagtaccgac accagtaccc aaacttcaaa    840

gatatccgat atcaaaatga cttgagcaat cttcgttttt ataagaataa aattccattc    900

aagccagatg gtgtttacat tgaagaagtt ctaagtaaat ggaaaggaga ttatgaaaaa    960

ctggagcaca accacactta cattcaatgg cttttccccc tgagagaaca aggcttgaac   1020

ttctatgcca aagaactaac tacatatgaa attgaggaat tcaaaaaaac aaaagaagca   1080

attagaagat tcctcctggc ttataaaatg atgctagaat tttttggaat aaaactgact   1140

gataaaactg gaaatgttgc tcgggctgtt aactggcagg aaagatttca gcatctgaat   1200

gagtcccagc acaactattt aagaatcact cgtattctta aaagccttgg tgagcttgga   1260

tatgaaagtt ttaaatctcc tcttgtaaaa tttattcttc atgaagctct tgtggagaat   1320

actattccca atattaagca gagtgctcta gagtattttg tttatacaat tagagacaga   1380

agagaaagga gaaagctcct gcggttcgcc cagaaacact acacgccttc agagaacttt   1440

atctggggac cgcctcgaaa agaacagtcg gagggaagca aagcccagaa aatgtcttcc   1500

cctctcgcct ccagtcataa cagtcaaact tctatgcaca aaaaagccaa ggactccaaa   1560

aattcctcct cagctgttca tttaaatagc aaaacagctg aagacaaaaa agtggcacca   1620

aaagagcctg tggaagagac agacaggccc agcccagagc ccagcaatga agctgccaag   1680

ccaagaaata cagagaagga cagtaatgct gagaacatga attctcaacc tgagaaaaca   1740

gttactactc ccacagaaaa aaaggagagt gtatctcctg agaataacga agaaggtgga   1800

aatgataacc aagacaatga aaatcctgga aatacaaatt gccatgatgt tgtactagta   1860

cagtgaatta tcagaaaacc cagaagccag tttaggctag agaggaaaaa actactgtat   1920

catttatcct aaagaacaga gatgaggtca atttcaaatt ttagccatct gtttgtgatt   1980

tctgtcataa gcattttgtt gtttgttttt ttattttgga tgacaatgaa ttgaatatct   2040

aataaggaga tttaagataa gacccaataa atgaatgtat tctgtaatgc ttttaggatg   2100

tgaattttca aattttgtat ataataatta ctttgagaat attttcagag tatctagaaa   2160

ttaccatgta gtatttggta tacaaaatac attcttttga gacattatag tctacatgaa   2220

ggaaatcaag aggataattt cattggattg ctacactttt acctgattta tggctttatt   2280

ttactttatt ttattttatt attatttttt gagacggagt ctctgttgcc caggctggag   2340

tgcagtggca tgatctcggc tcactgcaac ctctgcctcc tggactcaaa cgattctcct   2400

gcctcagcct cctgagtagc tgggattaca ggcgtgtgcc accacgcctg gctaattttt   2460

gtatttttag tagagacggg gtttcaccat gttggtcagg ctggtctcaa actcctgacc   2520

tcatgatcca cccgcctcgg cctcccaaag tgctgggatt acaggcatga gccaccatgt   2580

ctggctgatt aatttttttt ttaactgtaa gagtttgatc ttttcaaatg tgttcagaaa   2640

ctaatttgga ttctttgatt ctagtatctc aacgtgttta tttttagatt ctgataagtg   2700

aaatggatgt ccttgtggag ctctggcctc cccagcttat ctatcagtcc tgctgtcctc   2760

acctccttgc ctctttccat gcttaccctt aagccaccat ctttctcagc tagcgtgtgt   2820

gtttctagtg tagttggccc tccatattca ggggtccagc atctgtggat tcaaccaacc   2880

gcagattgaa aatatttgtt ggaaaaaatg gatggttaca tctctactaa atatgtgcag   2940

tccttttatt tgtcattatt ctctaaacaa tacagtataa caactattga catagcattt   3000

atattgtatg tattaggtat tgtaagtaat ttagagatga tttaaagtat tttacataag   3060

ggacttgagc attcctagat tttggtaact gcagagggtc ctggaaccaa ccccctacag   3120

atatcaaggg accactatac acattaggat gatctatatt gaaatctaca tggaacagag   3180

tgggacttct aattgtatga cttcaagatt ttgctttgtt taaattaata actgttttca   3240

gaattaagtg cttaaaaaca aatttgattg aaaagttcaa gacaagaatt ttgctctcta   3300

tggctgttcc atataaattt gatggttgat tctgaatgta aatgactgaa gaattaaaaa   3360

ataagaaatt cctttttaaa aggcatgcct cttgcactgt gaacaagaca gtagtccctt   3420

aaaccatgaa tatgtcagtg ttctatggat tacgaaatta gtaatgttgc ttagcccaaa   3480

cgtgtttttt aaaaagtata gttttgtaca tctctaagtt atcaaacttc aaaattgaga   3540

acaaatttaa aagtccatat atgcaactct agtaagcact taataggtta catagcactg   3600

gttaagaaca attaattttg tttctatatt attactaatt attattacaa atcaaaaaac   3660

actgtgataa gaacttcaaa gcatatatac aaatatagtt aaagcaatga atagatgaaa   3720

catgtctact ttatttcatt tagaaaggaa ttaacttttt tgttaggctt ttaagaaaag   3780

ttctattcat tttaatcccc tagggaattt gtaatatgtc ctacttcata tcatcttctg   3840

ttgcctctat tgatccacat tttctgcagt ggatttcttg aaaagaatca cacttatagt   3900

atgcctctag aaatatgatt ttactgcttt gaagtttaca tgaaacatgc cagttgctta   3960

actctaattt tttatatgaa tctcagtagc acttttgttg tacattgtgt tccaataagt   4020

atagtatgga acactttctc atttttagtt cccataatat gccagttttt gctttcctag   4080

tgttctgtga gtattaggat ttggcaatct gcttttgcat ttcaatttct gttttacatg   4140

caagaaaaac atggacactc ttacgtggtg cttgtagctg tgtctccgta gagctcagta   4200

aatagttcta cagggtttag aggatgagaa gcgattgtca aattaggctg aattgtagaa   4260

cacaaataat ttaattcaaa ataacttacc aattttatat acatgataaa gtattcagac   4320

aactttctaa atgcataata gtaaaagatt gtgaccagat attatgatat taataaagtt   4380

accagatact aaaatcaatg aatgtaattt gaattactta gaaattgtat attagagccc   4440

ttatgagtaa aaacatttca tttagcaact taacttttag aatattcttc ctacttaggg   4500

attttgatta gattgtaaca ttaaattcga gaatatttag tctcaagaga aacacttcct   4560

ggcatccatc ttaaatagtg gccttttccc actatggtgt ttttaaatgc atattcatat   4620

ataatagtat gtttcttaca tttaatccct aaataactta gataatcatt cagtggagaa   4680

caagtaaaag gatatcattc cttttggaga taaacattga gtgtctagaa tttttttcta   4740

ttaatgcttt gtatattagt tttttaaata agatctatag atatgtattt atgtgtgtct   4800

tatatatgaa acagtgctct gggtttgact cctatgtttt gtaattttaa aaactacgat   4860

atgcttgcag aaattcattg agaagctgtt ataaaaaatg cagtgaagca tgaccaaata   4920

gctaaaaata ttactgaatc tttacaaata tataatcttt attgttgtac tgtggagtgc   4980

aaggatacta aatattggct attgataaaa tactaacttg catttcatgg caaatagatg   5040

ttatatcgct tgattagtct agaacatttc taatattttg tgctttcata tatcaaagga   5100

gattatgtga aactattttt aaatactgta aagtgacata tagttataag atatatttct   5160

gtacagtaga gaaagagttt ataacatgaa gaatattgta ccattataca ttttcattct   5220

cgatctcata agaaattcaa aagaataatg atagaggtga aaatatgttt actttctcta   5280

aatcaagcct agttgtcaac tcaaaaatta tgttgcatag ttttattttg aatttaggtt   5340

ttgggactac ttttttccag cttcaatgag aaaataaaat ctacaactca ggagttacta   5400

gagaagttct aagtattttt ttgctaagta gtaaaaatat aaacatatga aaatgccata   5460

atgcctgtca tagtcattgt ttcatatttt gtcatataaa atcacctacc ctgcttctag   5520

ttttatactt taatctgagt gaaagtatga tgtggtggaa agaaaaaaca gtacagtatt   5580

acatctgagt tagtctttga aaaatcatag tagtaaatga acctcaacac tgagtggtca   5640

aaaattgggt taaccaatgg ggggagaata tttggttaat tgttttaata ttaaattttc   5700

aagtttataa tagagttatg gttgagtagt catccatact gagtaatcac gcatttttta   5760

aactataatt gaggctcttc taaagctttg ttttctaatc taagatacaa aggatattct   5820

tgatcttgct tgattgtaac tacatctacc agtctttaat gtctgtttgg ggtgagtggc   5880

gatcctctgt tgtaggaatg tttttgaaga tttctatttt gttttccact taggaaattc   5940

ccctctctca tttggggtat atgcgttgag tataaggtag gctgtattta gacacactag   6000

aatcattaaa tgtaggtgaa gttgtagaga aaaatggcct gggtcaatgt aggatctaga   6060

aaattaggag tgtacatttg ctggcttctt tttgagtttt gtactgttta ttacaggaac   6120

atatttgtgt ggctaatctc tagggtgaca gtgagtacta ccctgctcct tctgcattct   6180

agttatccaa cacacccagc agattgtgtt cagggacaga atgtgttttt agaaatccct   6240

tattattgaa atgaataata atatagctat aaatatgaat gtctggaggt atccagatgt   6300

gccttaacaa atgtaaatgg ttttcattca gaagtttaca tttttattac attataaaat   6360

ctcatcattg ggaactttct aaaccatgaa tatcagttct tttaatgaaa tttaggtggt   6420

gctttatcat tttggagaag ttgctgtttg ggacaatagc atcagtttat caagaagtgt   6480

actcaccatg atattcaaca atgtgttaca tttgacaaaa cgtgtttaga gtaagaaaga   6540

ctaactatac tgtctgttat atttatttat gctttttgta gtttagctac atactataat   6600

tttcatttta aacgttcctt agttactaca aataatattt atgttttgct tcttcttaga   6660

tgtaggcgga tgcagaaata gaattatgtt agagaaatta ttaaaagttt aattccagta   6720

ggcagttgga gaaatctgaa actaatttga aaaactttta tgctgtagtc tcattagaat   6780

cattttaaaa gcactgttct tgcatttttc ctagactaca gagagtgttc tttgtcattt   6840

tttttcctat tctgttgtga agtttattgt ttcagttatt tgagggaaat aacctcttaa   6900

tatgtttatt ttcctgaact aaagttttca tgtagagaat acaattaaat gttttgtgtt   6960

atgacccaaa ctggctggaa gtagagttca gagagggaga agggacaaga atcagtgtgg   7020

gcatctcagg aaagtggcgc cagtgctggg ctccagcctt ctccactggc atgatgggtc   7080

ctcagattct cctctggata atgagggtgt tgggcactgt gagctctgac ttctggggag   7140

gataggccat catggactcc atacacaatt ttgatgggta tcagttctca taaaatacct   7200

gctacaattt atttattttg tagttgttta gaaaactgtg agcagttggg cattagtaaa   7260

ttgtagttat atcttaacga tcttgggaat cattgaaata tgagtttttt tccctcactc   7320

ctatttattt aattaaaaaa ttagggaagt tgttcattca cagctgtata ttaatataaa   7380

atctctttat aaaatgattc agagaaaagg cagtagtggt cacttactgt gctaaaatac   7440

ctttttctct aaaaatattt aagctttagg gtttgtcata gttttacttt ttaaattata   7500

ctttgtgtaa caatttacgt taactagaaa aattagatat ataataagtt ttggtactaa   7560

gaaacattta cattctacac tcattagtca aatgaacttt tctttcccag tgctaacaga   7620

ttttgtttca tgtgaagaaa aataaaatac aaatgaaata aaagtctaga aacagcaaca   7680

ggaaactcac cacagaaata aagacataac ccttgataag tttgtgtaag tgccagaatt   7740

attggaagca ggtgacgaat gattaagaaa agctttattg tggggacatg ctttaagaat   7800

cagctctgta tttgtgccaa ggagatcagg tattggtgtg caaacagatc ccattaatac   7860

tctgatttga accatgaatt ccacctactc tgcgttgaag ccctccagta gactgataga   7920

tgtaatcaaa tgatcagcta ccaagtttaa ttcctttgcc tgtgtgtagc aacagttggt   7980

agttttacaa gttaagttga tggtctggct gcagataaga gaaagactca gtgataggtg   8040

gtttgtgagt gaagtaactt ccacactgtc aagagttgac agcatattaa ttgtgtggca   8100

ttataattgt gagaaacaaa tgagagcaaa atgttaggtc ctttgacaag cattttcctc   8160

ctgtttttaa aaagggcttt aagttgtttc ctatgtaagg taatctttct tttttagtat   8220

tatctaagaa ggatggtaga ttatgtcatt ttggaaacta ttgtgtccct tgtattttaa   8280

atatttcagg aaaatgccta cgattgttac aaagatgtgt gttttactta taacataagc   8340

tctgattctc cagtggccac tgggccttct ctgtgctctg tattcaactg cagtatgaat   8400

tacagaatgc tgtgcatgtt cgttagtacc aataccatgt gtatgtggta gaagttgtaa   8460

ccagtttctg gatctgtatg gtactataaa atacttattt tataattctg taaccgtatg   8520

gcagtgttat gccaaaaatg tataaagagc aatagttttt gttgcttact gctgtatttt   8580

aaaatattgt ttctaaaata atagagttag agttcctttt gagtaattat ttttaagaac   8640

tattgccaaa tatacatcct gtaaaactaa taaaagccac tccatcttag ataacatttt   8700

agcattgtgc tagagtacat tatggtgatt ttgcacgatt aaaatatttt taaagaacta   8760

g                                                                   8761


<210>  3293
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  3293

Met Gly Asn Leu Leu Gly Gly Val Ser Phe Arg Glu Pro Thr Thr Val 
1               5                   10                  15


Glu Asp Cys Asp Ser Thr Trp Gln Thr Asp Ser Glu Pro Glu Pro Glu 
            20                  25                  30


Glu Pro Gly Pro Gly Gly Gly Ser Glu Gly Pro Gly Gln Glu Ser Glu 
        35                  40                  45


Gln Pro Ala Gln Pro Pro Glu Gln Ala Gly Gly Arg Pro Gly Ala Ser 
    50                  55                  60


Pro Ala Pro Asp Glu Asp Ala Glu Ala Ala Gly Ala Glu Gln Gly Gly 
65                  70                  75                  80


Asp Ser Thr Glu Ala Thr Ala Lys Pro Lys Arg Ser Phe Tyr Ala Ala 
                85                  90                  95


Arg Asp Leu Tyr Lys Tyr Arg His Gln Tyr Pro Asn Phe Lys Asp Ile 
            100                 105                 110


Arg Tyr Gln Asn Asp Leu Ser Asn Leu Arg Phe Tyr Lys Asn Lys Ile 
        115                 120                 125


Pro Phe Lys Pro Asp Gly Val Tyr Ile Glu Glu Val Leu Ser Lys Trp 
    130                 135                 140


Lys Gly Asp Tyr Glu Lys Leu Glu His Asn His Thr Tyr Ile Gln Trp 
145                 150                 155                 160


Leu Phe Pro Leu Arg Glu Gln Gly Leu Asn Phe Tyr Ala Lys Glu Leu 
                165                 170                 175


Thr Thr Tyr Glu Ile Glu Glu Phe Lys Lys Thr Lys Glu Ala Ile Arg 
            180                 185                 190


Arg Phe Leu Leu Ala Tyr Lys Met Met Leu Glu Phe Phe Gly Ile Lys 
        195                 200                 205


Leu Thr Asp Lys Thr Gly Asn Val Ala Arg Ala Val Asn Trp Gln Glu 
    210                 215                 220


Arg Phe Gln His Leu Asn Glu Ser Gln His Asn Tyr Leu Arg Ile Thr 
225                 230                 235                 240


Arg Ile Leu Lys Ser Leu Gly Glu Leu Gly Tyr Glu Ser Phe Lys Ser 
                245                 250                 255


Pro Leu Val Lys Phe Ile Leu His Glu Ala Leu Val Glu Asn Thr Ile 
            260                 265                 270


Pro Asn Ile Lys Gln Ser Ala Leu Glu Tyr Phe Val Tyr Thr Ile Arg 
        275                 280                 285


Asp Arg Arg Glu Arg Arg Lys Leu Leu Arg Phe Ala Gln Lys His Tyr 
    290                 295                 300


Thr Pro Ser Glu Asn Phe Ile Trp Gly Pro Pro Arg Lys Glu Gln Ser 
305                 310                 315                 320


Glu Gly Ser Lys Ala Gln Lys Met Ser Ser Pro Leu Ala Ser Ser His 
                325                 330                 335


Asn Ser Gln Thr Ser Met His Lys Lys Ala Lys Asp Ser Lys Asn Ser 
            340                 345                 350


Ser Ser Ala Val His Leu Asn Ser Lys Thr Ala Glu Asp Lys Lys Val 
        355                 360                 365


Ala Pro Lys Glu Pro Val Glu Glu Thr Asp Arg Pro Ser Pro Glu Pro 
    370                 375                 380


Ser Asn Glu Ala Ala Lys Pro Arg Asn Thr Glu Lys Asp Ser Asn Ala 
385                 390                 395                 400


Glu Asn Met Asn Ser Gln Pro Glu Lys Thr Val Thr Thr Pro Thr Glu 
                405                 410                 415


Lys Lys Glu Ser Val Ser Pro Glu Asn Asn Glu Glu Gly Gly Asn Asp 
            420                 425                 430


Asn Gln Asp Asn Glu Asn Pro Gly Asn Thr Asn Cys His Asp Val Val 
        435                 440                 445


Leu Val Gln 
    450


<210>  3294
<211>  8875
<212>  DNA
<213>  Homo sapiens

<400>  3294
tcgacaccac gtccacgcca gtcctcagct ccaggagctg ggcgggatcc ctcatcccgc     60

tcagctggga gatgccccgg gagggcgtcc cccggctccg ggcggcgagg gtagtagccg    120

accccaatcc actccggggg ccgccggggg ccgcgtgaag gcaggtgttc cggggagaaa    180

cgtggaaggg aggcgcggcc tggggccggt ggcgctcggc tgggggccgc agttggctcc    240

cctgggggct ctgggcggcg gcagctcccg cctgtgggga ggagaaggag ccggatgggc    300

gggttcaggc gcgcgcggcg gcggtcccgg ggccgccggc tcctccccgc gagggtgcct    360

gtccgccgct cgccgcgctg aggcagtgcg gggcgggcgc gcctaggctg ccgcccagcg    420

ccctcgccgc ggccatgccc gggccctaga gcgcctgccg cagcttgcgc cccgcagccc    480

cgcagccccg cgcccgccgc cgcctcttca atgggcaacc tgctcggcgg ggtcagcttc    540

cgcgagccca ccaccgtgga ggactgcgac tccacctggc agaccgactc ggagcccgag    600

cccgaagaac cagggccggg cggcggcagc gagggcccgg ggcaggagtc cgagcagccc    660

gcgcagcccc cggagcaagc cggcgggcgg cccggcgcca gccccgcgcc ggacgaggac    720

gccgaggcgg cgggcgccga gcagggtggt gattccactg aagcaactgc caaaccaaag    780

agaagttttt atgctgccag ggatttgtac aagtaccgac accagtaccc aaacttcaaa    840

gatatccgat atcaaaatga cttgagcaat cttcgttttt ataagaataa aattccattc    900

aagccagatg gtgtttacat tgaagaagtt ctaagtaaat ggaaaggaga ttatgaaaaa    960

ctggagcaca accacactta cattcaatgg cttttccccc tgagagaaca aggcttgaac   1020

ttctatgcca aagaactaac tacatatgaa attgaggaat tcaaaaaaac aaaagaagca   1080

attagaagat tcctcctggc ttataaaatg atgctagaat tttttggaat aaaactgact   1140

gataaaactg gaaatgttgc tcgggctgtt aactggcagg aaagatttca gcatctgaat   1200

gagtcccagc acaactattt aagaatcact cgtattctta aaagccttgg tgagcttgga   1260

tatgaaagtt ttaaatctcc tcttgtaaaa tttattcttc atgaagctct tgtggagaat   1320

actattccca atattaagca gagtgctcta gagtattttg tttatacaat tagagacaga   1380

agagaaagga gaaagctcct gcggttcgcc cagaaacact acacgccttc agagaacttt   1440

atctggggac cgcctcgaaa agaacagtcg gagggaagca aagcccagaa aatgtcttcc   1500

cctctcgcct ccagtcataa cagtcaaact tctatgcaca aaaaagccaa ggactccaaa   1560

aattcctcct cagctgttca tttaaatagc aaaacagctg aagacaaaaa agtggcacca   1620

aaagagcctg tggaagagac agacaggccc agcccagagc ccagcaatga agctgccaag   1680

ccaagaaata cagagaagga cagtaatgct gagaacatga attctcaacc tgagaaaaca   1740

gttactactc ccacagaaaa aaaggagagt gtatctcctg agaataacga agaaggtgga   1800

aatgataacc aagacaatga aaatcctgga aatacaaatt gccatgatgt tgtactagta   1860

cagtgaatta tcagaaaacc cagaagccag tttaggctag agaggaaaaa actactgtat   1920

catttatcct aaagaacaga gatgaggtca atttcaaatt ttagccatct gtttgtgatt   1980

tctgtcataa gcattttgtt gtttgttttt ttattttgga tgacaatgaa ttgaatatct   2040

aataaggaga tttaagataa gacccaataa atgaatgtat tctgtaatgc ttttaggatg   2100

tgaattttca aattttgtat ataataatta ctttgagaat attttcagag tatctagaaa   2160

ttaccatgta gtatttggta tacaaaatac attcttttga gacattatag tctacatgaa   2220

ggaaatcaag aggataattt cattggattg ctacactttt acctgattta tggctttatt   2280

ttactttatt ttattttatt attatttttt gagacggagt ctctgttgcc caggctggag   2340

tgcagtggca tgatctcggc tcactgcaac ctctgcctcc tggactcaaa cgattctcct   2400

gcctcagcct cctgagtagc tgggattaca ggcgtgtgcc accacgcctg gctaattttt   2460

gtatttttag tagagacggg gtttcaccat gttggtcagg ctggtctcaa actcctgacc   2520

tcatgatcca cccgcctcgg cctcccaaag tgctgggatt acaggcatga gccaccatgt   2580

ctggctgatt aatttttttt ttaactgtaa gagtttgatc ttttcaaatg tgttcagaaa   2640

ctaatttgga ttctttgatt ctagtatctc aacgtgttta tttttagatt ctgataagtg   2700

aaatggatgt ccttgtggag ctctggcctc cccagcttat ctatcagtcc tgctgtcctc   2760

acctccttgc ctctttccat gcttaccctt aagccaccat ctttctcagc tagcgtgtgt   2820

gtttctagtg tagttggccc tccatattca ggggtccagc atctgtggat tcaaccaacc   2880

gcagattgaa aatatttgtt ggaaaaaatg gatggttaca tctctactaa atatgtgcag   2940

tccttttatt tgtcattatt ctctaaacaa tacagtataa caactattga catagcattt   3000

atattgtatg tattaggtat tgtaagtaat ttagagatga tttaaagtat tttacataag   3060

ggacttgagc attcctagat tttggtaact gcagagggtc ctggaaccaa ccccctacag   3120

atatcaaggg accactatac acattaggat gatctatatt gaaatctaca tggaacagag   3180

tgggacttct aattgtatga cttcaagatt ttgctttgtt taaattaata actgttttca   3240

gaattaagtg cttaaaaaca aatttgattg aaaagttcaa gacaagaatt ttgctctcta   3300

tggctgttcc atataaattt gatggttgat tctgaatgta aatgactgaa gaattaaaaa   3360

ataagaaatt cctttttaaa aggcatgcct cttgcactgt gaacaagaca gtagtccctt   3420

aaaccatgaa tatgtcagtg ttctatggat tacgaaatta gtaatgttgc ttagcccaaa   3480

cgtgtttttt aaaaagtata gttttgtaca tctctaagtt atcaaacttc aaaattgaga   3540

acaaatttaa aagtccatat atgcaactct agtaagcact taataggtta catagcactg   3600

gttaagaaca attaattttg tttctatatt attactaatt attattacaa atcaaaaaac   3660

actgtgataa gaacttcaaa gcatatatac aaatatagtt aaagcaatga atagatgaaa   3720

catgtctact ttatttcatt tagaaaggaa ttaacttttt tgttaggctt ttaagaaaag   3780

ttctattcat tttaatcccc tagggaattt gtaatatgtc ctacttcata tcatcttctg   3840

ttgcctctat tgatccacat tttctgcagt ggatttcttg aaaagaatca cacttatagt   3900

atgcctctag aaatatgatt ttactgcttt gaagtttaca tgaaacatgc cagttgctta   3960

actctaattt tttatatgaa tctcagtagc acttttgttg tacattgtgt tccaataagt   4020

atagtatgga acactttctc atttttagtt cccataatat gccagttttt gctttcctag   4080

tgttctgtga gtattaggat ttggcaatct gcttttgcat ttcaatttct gttttacatg   4140

caagaaaaac atggacactc ttacgtggtg cttgtagctg tgtctccgta gagctcagta   4200

aatagttcta cagggtttag aggatgagaa gcgattgtca aattaggctg aattgtagaa   4260

cacaaataat ttaattcaaa ataacttacc aattttatat acatgataaa gtattcagac   4320

aactttctaa atgcataata gtaaaagatt gtgaccagat attatgatat taataaagtt   4380

accagatact aaaatcaatg aatgtaattt gaattactta gaaattgtat attagagccc   4440

ttatgagtaa aaacatttca tttagcaact taacttttag aatattcttc ctacttaggg   4500

attttgatta gattgtaaca ttaaattcga gaatatttag tctcaagaga aacacttcct   4560

ggcatccatc ttaaatagtg gccttttccc actatggtgt ttttaaatgc atattcatat   4620

ataatagtat gtttcttaca tttaatccct aaataactta gataatcatt cagtggagaa   4680

caagtaaaag gatatcattc cttttggaga taaacattga gtgtctagaa tttttttcta   4740

ttaatgcttt gtatattagt tttttaaata agatctatag atatgtattt atgtgtgtct   4800

tatatatgaa acagtgctct gggtttgact cctatgtttt gtaattttaa aaactacgat   4860

atgcttgcag aaattcattg agaagctgtt ataaaaaatg cagtgaagca tgaccaaata   4920

gctaaaaata ttactgaatc tttacaaata tataatcttt attgttgtac tgtggagtgc   4980

aaggatacta aatattggct attgataaaa tactaacttg catttcatgg caaatagatg   5040

ttatatcgct tgattagtct agaacatttc taatattttg tgctttcata tatcaaagga   5100

gattatgtga aactattttt aaatactgta aagtgacata tagttataag atatatttct   5160

gtacagtaga gaaagagttt ataacatgaa gaatattgta ccattataca ttttcattct   5220

cgatctcata agaaattcaa aagaataatg atagaggtga aaatatgttt actttctcta   5280

aatcaagcct agttgtcaac tcaaaaatta tgttgcatag ttttattttg aatttaggtt   5340

ttgggactac ttttttccag cttcaatgag aaaataaaat ctacaactca ggagttacta   5400

gagaagttct aagtattttt ttgctaagta gtaaaaatat aaacatatga aaatgccata   5460

atgcctgtca tagtcattgt ttcatatttt gtcatataaa atcacctacc ctgcttctag   5520

ttttatactt taatctgagt gaaagtatga tgtggtggaa agaaaaaaca gtacagtatt   5580

acatctgagt tagtctttga aaaatcatag tagtaaatga acctcaacac tgagtggtca   5640

aaaattgggt taaccaatgg ggggagaata tttggttaat tgttttaata ttaaattttc   5700

aagtttataa tagagttatg gttgagtagt catccatact gagtaatcac gcatttttta   5760

aactataatt gaggctcttc taaagctttg ttttctaatc taagatacaa aggatattct   5820

tgatcttgct tgattgtaac tacatctacc agtctttaat gtctgtttgg ggtgagtggc   5880

gatcctctgt tgtaggaatg tttttgaaga tttctatttt gttttccact taggaaattc   5940

ccctctctca tttggggtat atgcgttgag tataaggtag gctgtattta gacacactag   6000

aatcattaaa tgtaggtgaa gttgtagaga aaaatggcct gggtcaatgt aggatctaga   6060

aaattaggag tgtacatttg ctggcttctt tttgagtttt gtactgttta ttacaggaac   6120

atatttgtgt ggctaatctc tagggtgaca gtgagtacta ccctgctcct tctgcattct   6180

agttatccaa cacacccagc agattgtgtt cagggacaga atgtgttttt agaaatccct   6240

tattattgaa atgaataata atatagctat aaatatgaat gtctggaggt atccagatgt   6300

gccttaacaa atgtaaatgg ttttcattca gaagtttaca tttttattac attataaaat   6360

ctcatcattg ggaactttct aaaccatgaa tatcagttct tttaatgaaa tttaggtggt   6420

gctttatcat tttggagaag ttgctgtttg ggacaatagc atcagtttat caagaagtgt   6480

actcaccatg atattcaaca atgtgttaca tttgacaaaa cgtgtttaga gtaagaaaga   6540

ctaactatac tgtctgttat atttatttat gctttttgta gtttagctac atactataat   6600

tttcatttta aacgttcctt agttactaca aataatattt atgttttgct tcttcttaga   6660

tgtaggcgga tgcagaaata gaattatgtt agagaaatta ttaaaagttt aattccagta   6720

ggcagttgga gaaatctgaa actaatttga aaaactttta tgctgtagtc tcattagaat   6780

cattttaaaa gcactgttct tgcatttttc ctagactaca gagagtgttc tttgtcattt   6840

tttttcctat tctgttgtga agtttattgt ttcagttatt tgagggaaat aacctcttaa   6900

tatgtttatt ttcctgaact aaagttttca tgtagagaat acaattaaat gttttgtgtt   6960

atgacccaaa ctggctggaa gtagagttca gagagggaga agggacaaga atcagtgtgg   7020

gcatctcagg aaagtggcgc cagtgctggg ctccagcctt ctccactggc atgatgggtc   7080

ctcagattct cctctggata atgagggtgt tgggcactgt gagctctgac ttctggggag   7140

gataggccat catggactcc atacacaatt ttgatgggta tcagttctca taaaatacct   7200

gctacaattt atttattttg tagttgttta gaaaactgtg agcagttggg cattagtaaa   7260

ttgtagttat atcttaacga tcttgggaat cattgaaata tgagtttttt tccctcactc   7320

ctatttattt aattaaaaaa ttagggaagt tgttcattca cagctgtata ttaatataaa   7380

atctctttat aaaatgattc agagaaaagg cagtagtggt cacttactgt gctaaaatac   7440

ctttttctct aaaaatattt aagctttagg gtttgtcata gttttacttt ttaaattata   7500

ctttgtgtaa caatttacgt taactagaaa aattagatat ataataagtt ttggtactaa   7560

gaaacattta cattctacac tcattagtca aatgaacttt tctttcccag tgctaacaga   7620

ttttgtttca tgtgaagaaa aataaaatac aaatgaaata aaagtctaga aacagcaaca   7680

ggaaactcac cacagaaata aagacataac ccttgataag tttgtgtaag tgccagaatt   7740

attggaagca ggtgacgaat gattaagaaa agctttattg tggggacatg ctttaagaat   7800

cagctctgta tttgtgccaa ggagatcagg tattggtgtg caaacagatc ccattaatac   7860

tctgatttga accatgaatt ccacctactc tgcgttgaag ccctccagta gactgataga   7920

tgtaatcaaa tgatcagcta ccaagtttaa ttcctttgcc tgtgtgtagc aacagttggt   7980

agttttacaa gttaagttga tggtctggct gcagataaga gaaagactca gtgataggtg   8040

gtttgtgagt gaagtaactt ccacactgtc aagagttgac agcatattaa ttgtgtggca   8100

ttataattgt gagaaacaaa tgagagcaaa atgttaggtc ctttgacaag cattttcctc   8160

ctgtttttaa aaagggcttt aagttgtttc ctatgtaagg taatctttct tttttagtat   8220

tatctaagaa ggatggtaga ttatgtcatt ttggaaacta ttgtgtccct tgtattttaa   8280

atatttcagg aaaatgccta cgattgttac aaagatgtgt gttttactta taacataagc   8340

tctgattctc cagtggccac tgggccttct ctgtgctctg tattcaactg cagtatgaat   8400

tacagaatgc tgtgcatgtt cgttagtacc aataccatgt gtatgtggta gaagttgtaa   8460

ccagtttctg gatctgtatg gtactataaa atacttattt tataattctg taaccgtatg   8520

gcagtgttat gccaaaaatg tataaagagc aatagttttt gttgcttact gctgtatttt   8580

aaaatattgt ttctaaaata atagagttag agttcctttt gagtaattat ttttaagaac   8640

tattgccaaa tatacatcct gtaaaactaa taaaagccac tccatcttag ataacatttt   8700

agcattgtgc tagagtacat tatggtgatt ttgcacgatt aaaatatttt taaagaacta   8760

gaaaaaatga cttgctgttt tcctgtcatt aagcatgtat tttttatgat taacacataa   8820

gactaacatt attttctttt atcctcaaaa ataaatattg tgaagggtga atcat        8875


<210>  3295
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  3295

Met Gly Asn Leu Leu Gly Gly Val Ser Phe Arg Glu Pro Thr Thr Val 
1               5                   10                  15


Glu Asp Cys Asp Ser Thr Trp Gln Thr Asp Ser Glu Pro Glu Pro Glu 
            20                  25                  30


Glu Pro Gly Pro Gly Gly Gly Ser Glu Gly Pro Gly Gln Glu Ser Glu 
        35                  40                  45


Gln Pro Ala Gln Pro Pro Glu Gln Ala Gly Gly Arg Pro Gly Ala Ser 
    50                  55                  60


Pro Ala Pro Asp Glu Asp Ala Glu Ala Ala Gly Ala Glu Gln Gly Gly 
65                  70                  75                  80


Asp Ser Thr Glu Ala Thr Ala Lys Pro Lys Arg Ser Phe Tyr Ala Ala 
                85                  90                  95


Arg Asp Leu Tyr Lys Tyr Arg His Gln Tyr Pro Asn Phe Lys Asp Ile 
            100                 105                 110


Arg Tyr Gln Asn Asp Leu Ser Asn Leu Arg Phe Tyr Lys Asn Lys Ile 
        115                 120                 125


Pro Phe Lys Pro Asp Gly Val Tyr Ile Glu Glu Val Leu Ser Lys Trp 
    130                 135                 140


Lys Gly Asp Tyr Glu Lys Leu Glu His Asn His Thr Tyr Ile Gln Trp 
145                 150                 155                 160


Leu Phe Pro Leu Arg Glu Gln Gly Leu Asn Phe Tyr Ala Lys Glu Leu 
                165                 170                 175


Thr Thr Tyr Glu Ile Glu Glu Phe Lys Lys Thr Lys Glu Ala Ile Arg 
            180                 185                 190


Arg Phe Leu Leu Ala Tyr Lys Met Met Leu Glu Phe Phe Gly Ile Lys 
        195                 200                 205


Leu Thr Asp Lys Thr Gly Asn Val Ala Arg Ala Val Asn Trp Gln Glu 
    210                 215                 220


Arg Phe Gln His Leu Asn Glu Ser Gln His Asn Tyr Leu Arg Ile Thr 
225                 230                 235                 240


Arg Ile Leu Lys Ser Leu Gly Glu Leu Gly Tyr Glu Ser Phe Lys Ser 
                245                 250                 255


Pro Leu Val Lys Phe Ile Leu His Glu Ala Leu Val Glu Asn Thr Ile 
            260                 265                 270


Pro Asn Ile Lys Gln Ser Ala Leu Glu Tyr Phe Val Tyr Thr Ile Arg 
        275                 280                 285


Asp Arg Arg Glu Arg Arg Lys Leu Leu Arg Phe Ala Gln Lys His Tyr 
    290                 295                 300


Thr Pro Ser Glu Asn Phe Ile Trp Gly Pro Pro Arg Lys Glu Gln Ser 
305                 310                 315                 320


Glu Gly Ser Lys Ala Gln Lys Met Ser Ser Pro Leu Ala Ser Ser His 
                325                 330                 335


Asn Ser Gln Thr Ser Met His Lys Lys Ala Lys Asp Ser Lys Asn Ser 
            340                 345                 350


Ser Ser Ala Val His Leu Asn Ser Lys Thr Ala Glu Asp Lys Lys Val 
        355                 360                 365


Ala Pro Lys Glu Pro Val Glu Glu Thr Asp Arg Pro Ser Pro Glu Pro 
    370                 375                 380


Ser Asn Glu Ala Ala Lys Pro Arg Asn Thr Glu Lys Asp Ser Asn Ala 
385                 390                 395                 400


Glu Asn Met Asn Ser Gln Pro Glu Lys Thr Val Thr Thr Pro Thr Glu 
                405                 410                 415


Lys Lys Glu Ser Val Ser Pro Glu Asn Asn Glu Glu Gly Gly Asn Asp 
            420                 425                 430


Asn Gln Asp Asn Glu Asn Pro Gly Asn Thr Asn Cys His Asp Val Val 
        435                 440                 445


Leu Val Gln 
    450


<210>  3296
<211>  1160
<212>  DNA
<213>  Homo sapiens

<400>  3296
atcattttag atacctcaaa cttgttattt ttggttggaa tagcaatctt gcttaataaa     60

tttttattga atgaataaat gattaacaaa atatggtctt cagcttaaat cctccttgga    120

gttttgttat catatgtgta aaactgagac atctgtgctg cattttaccc tctgggcttc    180

acagttgaat gttaagacaa taatttttta gtaaacatcc agaaagatga agatgatgaa    240

ctgttgggct tagcttttcc agtgtttggt cccagcacaa ctatttaaga atcactcgta    300

ttcttaaaag ccttggtgag cttggatatg aaagttttaa atctcctctt gtaaaattta    360

ttcttcatga agctcttgtg gagaatacta ttcccaatat taagcagagt gctctagagt    420

attttgttta tacaattaga gacagaagag aaaggagaaa gctcctgcgg ttcgcccaga    480

aacactacac gccttcagag aactttatct ggggaccgcc tcgaaaagaa cagtcggagg    540

gaagcaaagc ccagaaaatg tcttcccctc tcgcctccag tcataacagt caaacttcta    600

tgcacaaaaa agccaaggac tccaaaaatt cctcctcagc tgttcattta aatagcaaaa    660

cagctgaaga caaaaaagtg gcaccaaaag agcctgtgga agagacagac aggcccagcc    720

cagagcccag caatgaagct gccaagccaa gaaatacaga gaaggacagt aatgctgaga    780

acatgaattc tcaacctgag aaaacagtta ctactcccac agaaaaaaag gagagtgtat    840

ctcctgagaa taacgaagaa ggtggaaatg ataaccaaga caatgaaaat cctggaaata    900

caaattgcca tgatgttgta ctagtacagt gaattatcag aaaacccaga agccagttta    960

ggctagagag gaaaaaacta ctgtatcatt tatcctaaag aacagagatg aggtcaattt   1020

caaattttag ccatctgttt gtgatttctg tcataagcat tttgttgttt gtttttttat   1080

tttggatgac aatgaattga atatctaata aggagattta agataagacc caataaatga   1140

atgtattctg taatgctttt                                               1160


<210>  3297
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  3297

Met Val Phe Ser Leu Asn Pro Pro Trp Ser Phe Val Ile Ile Cys Val 
1               5                   10                  15


Lys Leu Arg His Leu Cys Cys Ile Leu Pro Ser Gly Leu His Ser 
            20                  25                  30


<210>  3298
<211>  7827
<212>  DNA
<213>  Homo sapiens

<400>  3298
atcattttag atacctcaaa cttgttattt ttggttggaa tagcaatctt gcttaataaa     60

tttttattga atgaataaat gattaacaaa atatggtctt cagcttaaat cctccttgga    120

gttttgttat catatgtgta aaactgagac atctgtgctg cattttaccc tctgggcttc    180

acagttgaat gttaagacaa taatttttta gtaaacatcc agaaagatga agatgatgaa    240

ctgttgggct tagcttttcc agtgtttggt cccagcacaa ctatttaaga atcactcgta    300

ttcttaaaag ccttggtgag cttggatatg aaagttttaa atctcctctt gtaaaattta    360

ttcttcatga agctcttgtg gagaatacta ttcccaatat taagcagagt gctctagagt    420

attttgttta tacaattaga gacagaagag aaaggagaaa gctcctgcgg ttcgcccaga    480

aacactacac gccttcagag aactttatct ggggaccgcc tcgaaaagaa cagtcggagg    540

gaagcaaagc ccagaaaatg tcttcccctc tcgcctccag tcataacagt caaacttcta    600

tgcacaaaaa agccaaggac tccaaaaatt cctcctcagc tgttcattta aatagcaaaa    660

cagctgaaga caaaaaagtg gcaccaaaag agcctgtgga agagacagac aggcccagcc    720

cagagcccag caatgaagct gccaagccaa gaaatacaga gaaggacagt aatgctgaga    780

acatgaattc tcaacctgag aaaacagtta ctactcccac agaaaaaaag gagagtgtat    840

ctcctgagaa taacgaagaa ggtggaaatg ataaccaaga caatgaaaat cctggaaata    900

caaattgcca tgatgttgta ctagtacagt gaattatcag aaaacccaga agccagttta    960

ggctagagag gaaaaaacta ctgtatcatt tatcctaaag aacagagatg aggtcaattt   1020

caaattttag ccatctgttt gtgatttctg tcataagcat tttgttgttt gtttttttat   1080

tttggatgac aatgaattga atatctaata aggagattta agataagacc caataaatga   1140

atgtattctg taatgctttt aggatgtgaa ttttcaaatt ttgtatataa taattacttt   1200

gagaatattt tcagagtatc tagaaattac catgtagtat ttggtataca aaatacattc   1260

ttttgagaca ttatagtcta catgaaggaa atcaagagga taatttcatt ggattgctac   1320

acttttacct gatttatggc tttattttac tttattttat tttattatta ttttttgaga   1380

cggagtctct gttgcccagg ctggagtgca gtggcatgat ctcggctcac tgcaacctct   1440

gcctcctgga ctcaaacgat tctcctgcct cagcctcctg agtagctggg attacaggcg   1500

tgtgccacca cgcctggcta atttttgtat ttttagtaga gacggggttt caccatgttg   1560

gtcaggctgg tctcaaactc ctgacctcat gatccacccg cctcggcctc ccaaagtgct   1620

gggattacag gcatgagcca ccatgtctgg ctgattaatt ttttttttaa ctgtaagagt   1680

ttgatctttt caaatgtgtt cagaaactaa tttggattct ttgattctag tatctcaacg   1740

tgtttatttt tagattctga taagtgaaat ggatgtcctt gtggagctct ggcctcccca   1800

gcttatctat cagtcctgct gtcctcacct ccttgcctct ttccatgctt acccttaagc   1860

caccatcttt ctcagctagc gtgtgtgttt ctagtgtagt tggccctcca tattcagggg   1920

tccagcatct gtggattcaa ccaaccgcag attgaaaata tttgttggaa aaaatggatg   1980

gttacatctc tactaaatat gtgcagtcct tttatttgtc attattctct aaacaataca   2040

gtataacaac tattgacata gcatttatat tgtatgtatt aggtattgta agtaatttag   2100

agatgattta aagtatttta cataagggac ttgagcattc ctagattttg gtaactgcag   2160

agggtcctgg aaccaacccc ctacagatat caagggacca ctatacacat taggatgatc   2220

tatattgaaa tctacatgga acagagtggg acttctaatt gtatgacttc aagattttgc   2280

tttgtttaaa ttaataactg ttttcagaat taagtgctta aaaacaaatt tgattgaaaa   2340

gttcaagaca agaattttgc tctctatggc tgttccatat aaatttgatg gttgattctg   2400

aatgtaaatg actgaagaat taaaaaataa gaaattcctt tttaaaaggc atgcctcttg   2460

cactgtgaac aagacagtag tcccttaaac catgaatatg tcagtgttct atggattacg   2520

aaattagtaa tgttgcttag cccaaacgtg ttttttaaaa agtatagttt tgtacatctc   2580

taagttatca aacttcaaaa ttgagaacaa atttaaaagt ccatatatgc aactctagta   2640

agcacttaat aggttacata gcactggtta agaacaatta attttgtttc tatattatta   2700

ctaattatta ttacaaatca aaaaacactg tgataagaac ttcaaagcat atatacaaat   2760

atagttaaag caatgaatag atgaaacatg tctactttat ttcatttaga aaggaattaa   2820

cttttttgtt aggcttttaa gaaaagttct attcatttta atcccctagg gaatttgtaa   2880

tatgtcctac ttcatatcat cttctgttgc ctctattgat ccacattttc tgcagtggat   2940

ttcttgaaaa gaatcacact tatagtatgc ctctagaaat atgattttac tgctttgaag   3000

tttacatgaa acatgccagt tgcttaactc taatttttta tatgaatctc agtagcactt   3060

ttgttgtaca ttgtgttcca ataagtatag tatggaacac tttctcattt ttagttccca   3120

taatatgcca gtttttgctt tcctagtgtt ctgtgagtat taggatttgg caatctgctt   3180

ttgcatttca atttctgttt tacatgcaag aaaaacatgg acactcttac gtggtgcttg   3240

tagctgtgtc tccgtagagc tcagtaaata gttctacagg gtttagagga tgagaagcga   3300

ttgtcaaatt aggctgaatt gtagaacaca aataatttaa ttcaaaataa cttaccaatt   3360

ttatatacat gataaagtat tcagacaact ttctaaatgc ataatagtaa aagattgtga   3420

ccagatatta tgatattaat aaagttacca gatactaaaa tcaatgaatg taatttgaat   3480

tacttagaaa ttgtatatta gagcccttat gagtaaaaac atttcattta gcaacttaac   3540

ttttagaata ttcttcctac ttagggattt tgattagatt gtaacattaa attcgagaat   3600

atttagtctc aagagaaaca cttcctggca tccatcttaa atagtggcct tttcccacta   3660

tggtgttttt aaatgcatat tcatatataa tagtatgttt cttacattta atccctaaat   3720

aacttagata atcattcagt ggagaacaag taaaaggata tcattccttt tggagataaa   3780

cattgagtgt ctagaatttt tttctattaa tgctttgtat attagttttt taaataagat   3840

ctatagatat gtatttatgt gtgtcttata tatgaaacag tgctctgggt ttgactccta   3900

tgttttgtaa ttttaaaaac tacgatatgc ttgcagaaat tcattgagaa gctgttataa   3960

aaaatgcagt gaagcatgac caaatagcta aaaatattac tgaatcttta caaatatata   4020

atctttattg ttgtactgtg gagtgcaagg atactaaata ttggctattg ataaaatact   4080

aacttgcatt tcatggcaaa tagatgttat atcgcttgat tagtctagaa catttctaat   4140

attttgtgct ttcatatatc aaaggagatt atgtgaaact atttttaaat actgtaaagt   4200

gacatatagt tataagatat atttctgtac agtagagaaa gagtttataa catgaagaat   4260

attgtaccat tatacatttt cattctcgat ctcataagaa attcaaaaga ataatgatag   4320

aggtgaaaat atgtttactt tctctaaatc aagcctagtt gtcaactcaa aaattatgtt   4380

gcatagtttt attttgaatt taggttttgg gactactttt ttccagcttc aatgagaaaa   4440

taaaatctac aactcaggag ttactagaga agttctaagt atttttttgc taagtagtaa   4500

aaatataaac atatgaaaat gccataatgc ctgtcatagt cattgtttca tattttgtca   4560

tataaaatca cctaccctgc ttctagtttt atactttaat ctgagtgaaa gtatgatgtg   4620

gtggaaagaa aaaacagtac agtattacat ctgagttagt ctttgaaaaa tcatagtagt   4680

aaatgaacct caacactgag tggtcaaaaa ttgggttaac caatgggggg agaatatttg   4740

gttaattgtt ttaatattaa attttcaagt ttataataga gttatggttg agtagtcatc   4800

catactgagt aatcacgcat tttttaaact ataattgagg ctcttctaaa gctttgtttt   4860

ctaatctaag atacaaagga tattcttgat cttgcttgat tgtaactaca tctaccagtc   4920

tttaatgtct gtttggggtg agtggcgatc ctctgttgta ggaatgtttt tgaagatttc   4980

tattttgttt tccacttagg aaattcccct ctctcatttg gggtatatgc gttgagtata   5040

aggtaggctg tatttagaca cactagaatc attaaatgta ggtgaagttg tagagaaaaa   5100

tggcctgggt caatgtagga tctagaaaat taggagtgta catttgctgg cttctttttg   5160

agttttgtac tgtttattac aggaacatat ttgtgtggct aatctctagg gtgacagtga   5220

gtactaccct gctccttctg cattctagtt atccaacaca cccagcagat tgtgttcagg   5280

gacagaatgt gtttttagaa atcccttatt attgaaatga ataataatat agctataaat   5340

atgaatgtct ggaggtatcc agatgtgcct taacaaatgt aaatggtttt cattcagaag   5400

tttacatttt tattacatta taaaatctca tcattgggaa ctttctaaac catgaatatc   5460

agttctttta atgaaattta ggtggtgctt tatcattttg gagaagttgc tgtttgggac   5520

aatagcatca gtttatcaag aagtgtactc accatgatat tcaacaatgt gttacatttg   5580

acaaaacgtg tttagagtaa gaaagactaa ctatactgtc tgttatattt atttatgctt   5640

tttgtagttt agctacatac tataattttc attttaaacg ttccttagtt actacaaata   5700

atatttatgt tttgcttctt cttagatgta ggcggatgca gaaatagaat tatgttagag   5760

aaattattaa aagtttaatt ccagtaggca gttggagaaa tctgaaacta atttgaaaaa   5820

cttttatgct gtagtctcat tagaatcatt ttaaaagcac tgttcttgca tttttcctag   5880

actacagaga gtgttctttg tcattttttt tcctattctg ttgtgaagtt tattgtttca   5940

gttatttgag ggaaataacc tcttaatatg tttattttcc tgaactaaag ttttcatgta   6000

gagaatacaa ttaaatgttt tgtgttatga cccaaactgg ctggaagtag agttcagaga   6060

gggagaaggg acaagaatca gtgtgggcat ctcaggaaag tggcgccagt gctgggctcc   6120

agccttctcc actggcatga tgggtcctca gattctcctc tggataatga gggtgttggg   6180

cactgtgagc tctgacttct ggggaggata ggccatcatg gactccatac acaattttga   6240

tgggtatcag ttctcataaa atacctgcta caatttattt attttgtagt tgtttagaaa   6300

actgtgagca gttgggcatt agtaaattgt agttatatct taacgatctt gggaatcatt   6360

gaaatatgag tttttttccc tcactcctat ttatttaatt aaaaaattag ggaagttgtt   6420

cattcacagc tgtatattaa tataaaatct ctttataaaa tgattcagag aaaaggcagt   6480

agtggtcact tactgtgcta aaataccttt ttctctaaaa atatttaagc tttagggttt   6540

gtcatagttt tactttttaa attatacttt gtgtaacaat ttacgttaac tagaaaaatt   6600

agatatataa taagttttgg tactaagaaa catttacatt ctacactcat tagtcaaatg   6660

aacttttctt tcccagtgct aacagatttt gtttcatgtg aagaaaaata aaatacaaat   6720

gaaataaaag tctagaaaca gcaacaggaa actcaccaca gaaataaaga cataaccctt   6780

gataagtttg tgtaagtgcc agaattattg gaagcaggtg acgaatgatt aagaaaagct   6840

ttattgtggg gacatgcttt aagaatcagc tctgtatttg tgccaaggag atcaggtatt   6900

ggtgtgcaaa cagatcccat taatactctg atttgaacca tgaattccac ctactctgcg   6960

ttgaagccct ccagtagact gatagatgta atcaaatgat cagctaccaa gtttaattcc   7020

tttgcctgtg tgtagcaaca gttggtagtt ttacaagtta agttgatggt ctggctgcag   7080

ataagagaaa gactcagtga taggtggttt gtgagtgaag taacttccac actgtcaaga   7140

gttgacagca tattaattgt gtggcattat aattgtgaga aacaaatgag agcaaaatgt   7200

taggtccttt gacaagcatt ttcctcctgt ttttaaaaag ggctttaagt tgtttcctat   7260

gtaaggtaat ctttcttttt tagtattatc taagaaggat ggtagattat gtcattttgg   7320

aaactattgt gtcccttgta ttttaaatat ttcaggaaaa tgcctacgat tgttacaaag   7380

atgtgtgttt tacttataac ataagctctg attctccagt ggccactggg ccttctctgt   7440

gctctgtatt caactgcagt atgaattaca gaatgctgtg catgttcgtt agtaccaata   7500

ccatgtgtat gtggtagaag ttgtaaccag tttctggatc tgtatggtac tataaaatac   7560

ttattttata attctgtaac cgtatggcag tgttatgcca aaaatgtata aagagcaata   7620

gtttttgttg cttactgctg tattttaaaa tattgtttct aaaataatag agttagagtt   7680

ccttttgagt aattattttt aagaactatt gccaaatata catcctgtaa aactaataaa   7740

agccactcca tcttagataa cattttagca ttgtgctaga gtacattatg gtgattttgc   7800

acgattaaaa tatttttaaa gaactag                                       7827


<210>  3299
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  3299

Met Val Phe Ser Leu Asn Pro Pro Trp Ser Phe Val Ile Ile Cys Val 
1               5                   10                  15


Lys Leu Arg His Leu Cys Cys Ile Leu Pro Ser Gly Leu His Ser 
            20                  25                  30


<210>  3300
<211>  7941
<212>  DNA
<213>  Homo sapiens

<400>  3300
atcattttag atacctcaaa cttgttattt ttggttggaa tagcaatctt gcttaataaa     60

tttttattga atgaataaat gattaacaaa atatggtctt cagcttaaat cctccttgga    120

gttttgttat catatgtgta aaactgagac atctgtgctg cattttaccc tctgggcttc    180

acagttgaat gttaagacaa taatttttta gtaaacatcc agaaagatga agatgatgaa    240

ctgttgggct tagcttttcc agtgtttggt cccagcacaa ctatttaaga atcactcgta    300

ttcttaaaag ccttggtgag cttggatatg aaagttttaa atctcctctt gtaaaattta    360

ttcttcatga agctcttgtg gagaatacta ttcccaatat taagcagagt gctctagagt    420

attttgttta tacaattaga gacagaagag aaaggagaaa gctcctgcgg ttcgcccaga    480

aacactacac gccttcagag aactttatct ggggaccgcc tcgaaaagaa cagtcggagg    540

gaagcaaagc ccagaaaatg tcttcccctc tcgcctccag tcataacagt caaacttcta    600

tgcacaaaaa agccaaggac tccaaaaatt cctcctcagc tgttcattta aatagcaaaa    660

cagctgaaga caaaaaagtg gcaccaaaag agcctgtgga agagacagac aggcccagcc    720

cagagcccag caatgaagct gccaagccaa gaaatacaga gaaggacagt aatgctgaga    780

acatgaattc tcaacctgag aaaacagtta ctactcccac agaaaaaaag gagagtgtat    840

ctcctgagaa taacgaagaa ggtggaaatg ataaccaaga caatgaaaat cctggaaata    900

caaattgcca tgatgttgta ctagtacagt gaattatcag aaaacccaga agccagttta    960

ggctagagag gaaaaaacta ctgtatcatt tatcctaaag aacagagatg aggtcaattt   1020

caaattttag ccatctgttt gtgatttctg tcataagcat tttgttgttt gtttttttat   1080

tttggatgac aatgaattga atatctaata aggagattta agataagacc caataaatga   1140

atgtattctg taatgctttt aggatgtgaa ttttcaaatt ttgtatataa taattacttt   1200

gagaatattt tcagagtatc tagaaattac catgtagtat ttggtataca aaatacattc   1260

ttttgagaca ttatagtcta catgaaggaa atcaagagga taatttcatt ggattgctac   1320

acttttacct gatttatggc tttattttac tttattttat tttattatta ttttttgaga   1380

cggagtctct gttgcccagg ctggagtgca gtggcatgat ctcggctcac tgcaacctct   1440

gcctcctgga ctcaaacgat tctcctgcct cagcctcctg agtagctggg attacaggcg   1500

tgtgccacca cgcctggcta atttttgtat ttttagtaga gacggggttt caccatgttg   1560

gtcaggctgg tctcaaactc ctgacctcat gatccacccg cctcggcctc ccaaagtgct   1620

gggattacag gcatgagcca ccatgtctgg ctgattaatt ttttttttaa ctgtaagagt   1680

ttgatctttt caaatgtgtt cagaaactaa tttggattct ttgattctag tatctcaacg   1740

tgtttatttt tagattctga taagtgaaat ggatgtcctt gtggagctct ggcctcccca   1800

gcttatctat cagtcctgct gtcctcacct ccttgcctct ttccatgctt acccttaagc   1860

caccatcttt ctcagctagc gtgtgtgttt ctagtgtagt tggccctcca tattcagggg   1920

tccagcatct gtggattcaa ccaaccgcag attgaaaata tttgttggaa aaaatggatg   1980

gttacatctc tactaaatat gtgcagtcct tttatttgtc attattctct aaacaataca   2040

gtataacaac tattgacata gcatttatat tgtatgtatt aggtattgta agtaatttag   2100

agatgattta aagtatttta cataagggac ttgagcattc ctagattttg gtaactgcag   2160

agggtcctgg aaccaacccc ctacagatat caagggacca ctatacacat taggatgatc   2220

tatattgaaa tctacatgga acagagtggg acttctaatt gtatgacttc aagattttgc   2280

tttgtttaaa ttaataactg ttttcagaat taagtgctta aaaacaaatt tgattgaaaa   2340

gttcaagaca agaattttgc tctctatggc tgttccatat aaatttgatg gttgattctg   2400

aatgtaaatg actgaagaat taaaaaataa gaaattcctt tttaaaaggc atgcctcttg   2460

cactgtgaac aagacagtag tcccttaaac catgaatatg tcagtgttct atggattacg   2520

aaattagtaa tgttgcttag cccaaacgtg ttttttaaaa agtatagttt tgtacatctc   2580

taagttatca aacttcaaaa ttgagaacaa atttaaaagt ccatatatgc aactctagta   2640

agcacttaat aggttacata gcactggtta agaacaatta attttgtttc tatattatta   2700

ctaattatta ttacaaatca aaaaacactg tgataagaac ttcaaagcat atatacaaat   2760

atagttaaag caatgaatag atgaaacatg tctactttat ttcatttaga aaggaattaa   2820

cttttttgtt aggcttttaa gaaaagttct attcatttta atcccctagg gaatttgtaa   2880

tatgtcctac ttcatatcat cttctgttgc ctctattgat ccacattttc tgcagtggat   2940

ttcttgaaaa gaatcacact tatagtatgc ctctagaaat atgattttac tgctttgaag   3000

tttacatgaa acatgccagt tgcttaactc taatttttta tatgaatctc agtagcactt   3060

ttgttgtaca ttgtgttcca ataagtatag tatggaacac tttctcattt ttagttccca   3120

taatatgcca gtttttgctt tcctagtgtt ctgtgagtat taggatttgg caatctgctt   3180

ttgcatttca atttctgttt tacatgcaag aaaaacatgg acactcttac gtggtgcttg   3240

tagctgtgtc tccgtagagc tcagtaaata gttctacagg gtttagagga tgagaagcga   3300

ttgtcaaatt aggctgaatt gtagaacaca aataatttaa ttcaaaataa cttaccaatt   3360

ttatatacat gataaagtat tcagacaact ttctaaatgc ataatagtaa aagattgtga   3420

ccagatatta tgatattaat aaagttacca gatactaaaa tcaatgaatg taatttgaat   3480

tacttagaaa ttgtatatta gagcccttat gagtaaaaac atttcattta gcaacttaac   3540

ttttagaata ttcttcctac ttagggattt tgattagatt gtaacattaa attcgagaat   3600

atttagtctc aagagaaaca cttcctggca tccatcttaa atagtggcct tttcccacta   3660

tggtgttttt aaatgcatat tcatatataa tagtatgttt cttacattta atccctaaat   3720

aacttagata atcattcagt ggagaacaag taaaaggata tcattccttt tggagataaa   3780

cattgagtgt ctagaatttt tttctattaa tgctttgtat attagttttt taaataagat   3840

ctatagatat gtatttatgt gtgtcttata tatgaaacag tgctctgggt ttgactccta   3900

tgttttgtaa ttttaaaaac tacgatatgc ttgcagaaat tcattgagaa gctgttataa   3960

aaaatgcagt gaagcatgac caaatagcta aaaatattac tgaatcttta caaatatata   4020

atctttattg ttgtactgtg gagtgcaagg atactaaata ttggctattg ataaaatact   4080

aacttgcatt tcatggcaaa tagatgttat atcgcttgat tagtctagaa catttctaat   4140

attttgtgct ttcatatatc aaaggagatt atgtgaaact atttttaaat actgtaaagt   4200

gacatatagt tataagatat atttctgtac agtagagaaa gagtttataa catgaagaat   4260

attgtaccat tatacatttt cattctcgat ctcataagaa attcaaaaga ataatgatag   4320

aggtgaaaat atgtttactt tctctaaatc aagcctagtt gtcaactcaa aaattatgtt   4380

gcatagtttt attttgaatt taggttttgg gactactttt ttccagcttc aatgagaaaa   4440

taaaatctac aactcaggag ttactagaga agttctaagt atttttttgc taagtagtaa   4500

aaatataaac atatgaaaat gccataatgc ctgtcatagt cattgtttca tattttgtca   4560

tataaaatca cctaccctgc ttctagtttt atactttaat ctgagtgaaa gtatgatgtg   4620

gtggaaagaa aaaacagtac agtattacat ctgagttagt ctttgaaaaa tcatagtagt   4680

aaatgaacct caacactgag tggtcaaaaa ttgggttaac caatgggggg agaatatttg   4740

gttaattgtt ttaatattaa attttcaagt ttataataga gttatggttg agtagtcatc   4800

catactgagt aatcacgcat tttttaaact ataattgagg ctcttctaaa gctttgtttt   4860

ctaatctaag atacaaagga tattcttgat cttgcttgat tgtaactaca tctaccagtc   4920

tttaatgtct gtttggggtg agtggcgatc ctctgttgta ggaatgtttt tgaagatttc   4980

tattttgttt tccacttagg aaattcccct ctctcatttg gggtatatgc gttgagtata   5040

aggtaggctg tatttagaca cactagaatc attaaatgta ggtgaagttg tagagaaaaa   5100

tggcctgggt caatgtagga tctagaaaat taggagtgta catttgctgg cttctttttg   5160

agttttgtac tgtttattac aggaacatat ttgtgtggct aatctctagg gtgacagtga   5220

gtactaccct gctccttctg cattctagtt atccaacaca cccagcagat tgtgttcagg   5280

gacagaatgt gtttttagaa atcccttatt attgaaatga ataataatat agctataaat   5340

atgaatgtct ggaggtatcc agatgtgcct taacaaatgt aaatggtttt cattcagaag   5400

tttacatttt tattacatta taaaatctca tcattgggaa ctttctaaac catgaatatc   5460

agttctttta atgaaattta ggtggtgctt tatcattttg gagaagttgc tgtttgggac   5520

aatagcatca gtttatcaag aagtgtactc accatgatat tcaacaatgt gttacatttg   5580

acaaaacgtg tttagagtaa gaaagactaa ctatactgtc tgttatattt atttatgctt   5640

tttgtagttt agctacatac tataattttc attttaaacg ttccttagtt actacaaata   5700

atatttatgt tttgcttctt cttagatgta ggcggatgca gaaatagaat tatgttagag   5760

aaattattaa aagtttaatt ccagtaggca gttggagaaa tctgaaacta atttgaaaaa   5820

cttttatgct gtagtctcat tagaatcatt ttaaaagcac tgttcttgca tttttcctag   5880

actacagaga gtgttctttg tcattttttt tcctattctg ttgtgaagtt tattgtttca   5940

gttatttgag ggaaataacc tcttaatatg tttattttcc tgaactaaag ttttcatgta   6000

gagaatacaa ttaaatgttt tgtgttatga cccaaactgg ctggaagtag agttcagaga   6060

gggagaaggg acaagaatca gtgtgggcat ctcaggaaag tggcgccagt gctgggctcc   6120

agccttctcc actggcatga tgggtcctca gattctcctc tggataatga gggtgttggg   6180

cactgtgagc tctgacttct ggggaggata ggccatcatg gactccatac acaattttga   6240

tgggtatcag ttctcataaa atacctgcta caatttattt attttgtagt tgtttagaaa   6300

actgtgagca gttgggcatt agtaaattgt agttatatct taacgatctt gggaatcatt   6360

gaaatatgag tttttttccc tcactcctat ttatttaatt aaaaaattag ggaagttgtt   6420

cattcacagc tgtatattaa tataaaatct ctttataaaa tgattcagag aaaaggcagt   6480

agtggtcact tactgtgcta aaataccttt ttctctaaaa atatttaagc tttagggttt   6540

gtcatagttt tactttttaa attatacttt gtgtaacaat ttacgttaac tagaaaaatt   6600

agatatataa taagttttgg tactaagaaa catttacatt ctacactcat tagtcaaatg   6660

aacttttctt tcccagtgct aacagatttt gtttcatgtg aagaaaaata aaatacaaat   6720

gaaataaaag tctagaaaca gcaacaggaa actcaccaca gaaataaaga cataaccctt   6780

gataagtttg tgtaagtgcc agaattattg gaagcaggtg acgaatgatt aagaaaagct   6840

ttattgtggg gacatgcttt aagaatcagc tctgtatttg tgccaaggag atcaggtatt   6900

ggtgtgcaaa cagatcccat taatactctg atttgaacca tgaattccac ctactctgcg   6960

ttgaagccct ccagtagact gatagatgta atcaaatgat cagctaccaa gtttaattcc   7020

tttgcctgtg tgtagcaaca gttggtagtt ttacaagtta agttgatggt ctggctgcag   7080

ataagagaaa gactcagtga taggtggttt gtgagtgaag taacttccac actgtcaaga   7140

gttgacagca tattaattgt gtggcattat aattgtgaga aacaaatgag agcaaaatgt   7200

taggtccttt gacaagcatt ttcctcctgt ttttaaaaag ggctttaagt tgtttcctat   7260

gtaaggtaat ctttcttttt tagtattatc taagaaggat ggtagattat gtcattttgg   7320

aaactattgt gtcccttgta ttttaaatat ttcaggaaaa tgcctacgat tgttacaaag   7380

atgtgtgttt tacttataac ataagctctg attctccagt ggccactggg ccttctctgt   7440

gctctgtatt caactgcagt atgaattaca gaatgctgtg catgttcgtt agtaccaata   7500

ccatgtgtat gtggtagaag ttgtaaccag tttctggatc tgtatggtac tataaaatac   7560

ttattttata attctgtaac cgtatggcag tgttatgcca aaaatgtata aagagcaata   7620

gtttttgttg cttactgctg tattttaaaa tattgtttct aaaataatag agttagagtt   7680

ccttttgagt aattattttt aagaactatt gccaaatata catcctgtaa aactaataaa   7740

agccactcca tcttagataa cattttagca ttgtgctaga gtacattatg gtgattttgc   7800

acgattaaaa tatttttaaa gaactagaaa aaatgacttg ctgttttcct gtcattaagc   7860

atgtattttt tatgattaac acataagact aacattattt tcttttatcc tcaaaaataa   7920

atattgtgaa gggtgaatca t                                             7941


<210>  3301
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  3301

Met Val Phe Ser Leu Asn Pro Pro Trp Ser Phe Val Ile Ile Cys Val 
1               5                   10                  15


Lys Leu Arg His Leu Cys Cys Ile Leu Pro Ser Gly Leu His Ser 
            20                  25                  30


<210>  3302
<211>  525
<212>  DNA
<213>  Homo sapiens

<400>  3302
cagcaaacct ttccctgctg tgaggtgggc aagttagttg ctccaaaaac aagataaaat     60

gattgagttc ttttctcaag cgggagtcgg agtttatctg ctctgagagc cccagcagct    120

actattaatg agtgtctgga atatgttcct ggcatttcac ctaccctctc tccaatcctt    180

ccaagaaact cacaaagcag ggctttttct tgaacttctc ttcctcacaa cagttaaatc    240

atccatttaa agatgtcaaa caacctccgt gttctaagaa ctatttactg agctctacgg    300

agacacagct acaagcacca catgctggac ccctgaatat ggagggccaa ctacactaga    360

aacacacacg ctagctgaga aagatggtgg cttaagggta agcatggaaa gaggcaagga    420

ggtgaggaca gcaggactga tagataagct ggggaggcca gagctccaca aggacatcca    480

tttcacttat cagaatctaa aaataaacac gttgagatac tagaa                    525


<210>  3303
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  3303

Met Ser Val Trp Asn Met Phe Leu Ala Phe His Leu Pro Ser Leu Gln 
1               5                   10                  15


Ser Phe Gln Glu Thr His Lys Ala Gly Leu Phe Leu Glu Leu Leu Phe 
            20                  25                  30


Leu Thr Thr Val Lys Ser Ser Ile 
        35                  40


<210>  3304
<211>  1184
<212>  DNA
<213>  Homo sapiens

<400>  3304
cattcagaag tttacatttt tattacatta taaaatctca tcattgggaa ctttctaaac     60

catgaatatc agttctttta atgaaattta ggtggtgctt tatcattttg gagaagttgc    120

tgtttgggac aatagcatca gtttatcaag aagtgtactc accatgatat tcaacaatgt    180

gttacatttg acaaaacgtg tttagagtaa gaaagactaa ctatactgtc tgttatattt    240

atttatgctt tttgtagttt agctacatac tataattttc attttaaacg ttccttagtt    300

actacaaata atatttatgt tttgcttctt cttagatgta ggcggatgca gaaatagaat    360

tatgttagag aaattattaa aagtttaatt ccagtaggca gttggagaaa tctgaaacta    420

atttgaaaaa cttttatgct gtagtctcat tagaatcatt ttaaaagcac tgttcttgca    480

tttttcctag actacagaga gtgttctttg tcattttttt tcctattctg ttgtgaagtt    540

tattgtttca gttatttgag ggaaataacc tcttaatatg tttattttcc tgaactaaag    600

ttttcatgta gagaatacaa ttaaatgttt tgtgttatga cccaaactgg ctggaagtag    660

agttcagaga gggagaaggg acaagaatca gtgtgggcat ctcaggaaag tggcgccagt    720

gctgggctcc agccttctcc actggcatga tgggtcctca gattctcctc tggataatga    780

gggtgttggg cactgtgagc tctgacttct ggggaggata ggccatcatg gactccatac    840

acaattttga tgggtatcag ttctcataaa atacctgcta caatttattt attttgtagt    900

tgtttagaaa actgtgagca gttgggcatt agtaaattgt agttatatct taacgatctt    960

gggaatcatt gaaatatgag tttttttccc tcatccatct tagataacat tttagcattg   1020

tgctagagta cattatggtg attttgcacg attaaaatat ttttaaagaa ctagaaaaaa   1080

tgacttgctg ttttcctgtc attaagcatg tattttttat gattaacaca taagactaac   1140

attattttct tttatcctca aaaataaata ttgtgaaggg tgaa                    1184


<210>  3305
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  3305

Met Gly Ile Ser Ser His Lys Ile Pro Ala Thr Ile Tyr Leu Phe Cys 
1               5                   10                  15


Ser Cys Leu Glu Asn Cys Glu Gln Leu Gly Ile Ser Lys Leu 
            20                  25                  30


<210>  3306
<211>  926
<212>  DNA
<213>  Homo sapiens

<400>  3306
cctttccctg ctgtgaggtg ggcaagttag ttgctccaaa aacaagataa aatgattgag     60

ttcttttctc aagcgggagt cggagtttat ctgctctgag agccccagca gctactatta    120

atgagtgtct ggaatatgtt cctggcattt cacctaccct ctctccaatc cttccaagaa    180

actcacaaag cagggctttt tcttgaactt ctcttcctca caacagttaa atcatccatt    240

taaagatgtc aaacaacctc cgtgttctaa gccagaccat caacttaact tgtaaaacta    300

ccaactgttg ctacacacag gcaaaggaat taaacttggt agctgatcat ttgattacat    360

ctatcagtct actggagggc ttcaacgcag agtaggtgga attcatggtt caaatcagag    420

tattaatggg atctgtttgc acaccaatac ctgatctcct tggcacaaat acagagctga    480

ttcttaaagc atgtccccac aataaagctt ttcttaatca ttcgtcacct gcttccaata    540

attctggcac ttacacaaac ttatcaaggg ttatgtcttt atttctgtgg tgagtttcct    600

gttgctgttt ctagactttt atttcatttg tattttattt ttcttcacat gaaacaaaat    660

ctgttagcac tgggaaagaa aagttcattt gactaatgag tgtagaatgt aaatgtttct    720

tagtaccaaa acttattata tatctaattt ttctagttaa cgtaaattgt tacacaaagt    780

ataatttaaa aagtaaaact atgacaaacc ctaaagctta aatattttta gagaaaaagg    840

tattttagca cagtaagtga ccactactgc cttttctctg aatcatttta taaagagatt    900

ttatattaat atacagctgt gaatga                                         926


<210>  3307
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  3307

Met Ser Asn Asn Leu Arg Val Leu Ser Gln Thr Ile Asn Leu Thr Cys 
1               5                   10                  15


Lys Thr Thr Asn Cys Cys Tyr Thr Gln Ala Lys Glu Leu Asn Leu Val 
            20                  25                  30


Ala Asp His Leu Ile Thr Ser Ile Ser Leu Leu Glu Gly Phe Asn Ala 
        35                  40                  45


Glu 



<210>  3308
<211>  352
<212>  DNA
<213>  Homo sapiens

<400>  3308
gtggtaaaca ggatagaaaa tgtctctgct ctagtggatc ttaattcaaa ttaggcagga     60

gatgatggta actttgatgt gagcattgga ggcagaagag aggagaatgg atgcaggatg    120

cattttggag ggagatctga tgaaatttgt gatggattag atgtgggtga taagagaaag    180

ctatggaaag aatgaaatca aggatgagca agtaggtgag taatggtaat atttactgag    240

atgaggaaga ctccatttct cccagcagcc ctttaagttg ggttcaccta tcccacccta    300

ttcctgtatc tattttattc tatatctata catctaacct ttatctatat tg            352


<210>  3309
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  3309

Asp Glu Glu Asp Ser Ile Ser Pro Ser Ser Pro Leu Ser Trp Val His 
1               5                   10                  15


Leu Ser His Pro Ile Pro Val Ser Ile Leu Phe Tyr Ile Tyr Thr Ser 
            20                  25                  30


Asn Leu Tyr Leu 
        35


<210>  3310
<211>  1345
<212>  DNA
<213>  Homo sapiens

<400>  3310
gctgcgcgag ccgctgcgga gggaagggct cctagccaat tggggtcttt gaggcgaatg     60

cgaggctggg gccggttgcc taccggccgc ttctcgccga ggcagtccag acttttcccc    120

cggcggtgcc cgctccaaga cagcatctgt caacgctcct cttctcccct cctcctcctg    180

ccgggccggg ctccgccggc tgcggccgag aggacgcggg acccggcgcg gtgagcccat    240

cagctgtcag gcgagcggcg aagcggctgg agggcggcga gagacacaca aagaacgcgg    300

tgggcggcgg cggcgaaagg ggacggcaac tcctccccgc gcccgccggt gccaccgccg    360

gccgtgcttg ttccgaggcc gcgcagacaa tgcggccggg ctcgtccccg cgtgccccag    420

agtgcggagc gcccgcgctc ccccgacccc aacttgaccg tctcccggct cgcccagccc    480

cctcccgggg taggggcgcc ccctccctcc ggtggccggc gaaggaagtc ggtccgcggc    540

cgcagatccc ggcaacttgc gaaccgggaa aagtttgcgg cgcctccgcg gggcggcgcg    600

acgcggcccg cccctcgcgt ccgcggtcat cgcgggtgac tttctcgact cgtcgtcagc    660

cggggccgca gcgcggccgg tggggactgc ggggcgggcc ggagtccgtc cgagggctcc    720

cgcacctcgg gctgcgggaa cattaaaatc tccccagatg ctcactgctc tgatcatttc    780

ccctacagca ccagacatgt tggcatcatc tcttagttgg gccatgtggc cagggaaccc    840

ttcatgaaac cacctctgca gtcctggaga gttgctgtag aagaaggaaa agagaggaag    900

acaacacaac acaggagggg ataagtacct ctggacacaa tggaagtagt agttgttgag    960

cagagggaaa gggataggag aaggatgtgg actgcagtgc tgcagtgcca gtggacatga   1020

gagaaagatc ccatagccct cttggtcttg gttggaacag gaggaaaatg aaaactggac   1080

atccatctta ggacttaatc ctacggagac cacaagctgg aagaggcact caatactagc   1140

atggcttctg tggcattttg atgagtagta tgggctccac actgaaatat taatatctta   1200

ttgttttgat gatgatgatg atgttcattg gcccagggca aaaggtaaag gttgtgttat   1260

aaagctgatc tattcaatat ctgtggatgt taactccacc ccatcccctt attgaacaat   1320

tacgatgcct ataaatattg tattg                                         1345


<210>  3311
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  3311

Met Arg Pro Gly Ser Ser Pro Arg Ala Pro Glu Cys Gly Ala Pro Ala 
1               5                   10                  15


Leu Pro Arg Pro Gln Leu Asp Arg Leu Pro Ala Arg Pro Ala Pro Ser 
            20                  25                  30


Arg Gly Arg Gly Ala Pro Ser Leu Arg Trp Pro Ala Lys Glu Val Gly 
        35                  40                  45


Pro Arg Pro Gln Ile Pro Ala Thr Cys Glu Pro Gly Lys Val Cys Gly 
    50                  55                  60


Ala Ser Ala Gly Arg Arg Asp Ala Ala Arg Pro Ser Arg Pro Arg Ser 
65                  70                  75                  80


Ser Arg Val Thr Phe Ser Thr Arg Arg Gln Pro Gly Pro Gln Arg Gly 
                85                  90                  95


Arg Trp Gly Leu Arg Gly Gly Pro Glu Ser Val Arg Gly Leu Pro His 
            100                 105                 110


Leu Gly Leu Arg Glu His 
        115


<210>  3312
<211>  966
<212>  DNA
<213>  Homo sapiens

<400>  3312
catatatatg aatgtcatat attttcatat atatgaatgt catatatttt catatatatg     60

aatgtcatat atattttcat atatatgaat gtcatatata ttttcatatc tatttcataa    120

atatatgaaa ttcatatcta tttcatatat atatgaaatt catatctatt tcatatatat    180

atgaaattca tatctatttc ataaatatat gaaattcata tctatttcat atatatatga    240

aattcatatc tatttcatat atatatgaaa ttcatatcta tttcatatat atatgaaatt    300

catatctatt ttcatatata tttcatatat attttccata tatatatata taaattcatc    360

agaacaaggt tgtctttttt tcttctgacc acaccaatgt aatgaaacag taagtgtgaa    420

aaagaaaaaa aaaaatacag gaatcaagag cccaaagaat ttttaaggaa accatgattg    480

aataggttat atcagactga ctggtctcct aactttgatt ctgcccacac cattcaatag    540

aaagaggaca tggaattcca gctattccct ccactataga atttactaca ttttaaattt    600

aaacaggtta atttaagcta cagtaataat ttgagacaga atctcatcaa gcacagattc    660

aaagtaccac actttgaggt cagagtggag agagcttttc ccttgggatg aacatgagaa    720

ggttaattaa agaggaagtg gactttctca gagcaaaggg tattttcata aaaccatgga    780

atctttgagt tggctaaatc tccataaatt ttatgaacat attgtgttct tttatctact    840

gtaaagtcac attactgttg attttccata tattttaact gtagtgagtt attctatgct    900

gtaattttcc tttaggatcc agggtaaata aaagcaaact agtataagaa cctttataag    960

ttactg                                                               966


<210>  3313
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  3313

Met Ser Tyr Ile Phe Ile Tyr Met Asn Val Ile Tyr Phe His Ile Tyr 
1               5                   10                  15


Glu Cys His Ile Tyr Phe His Ile Tyr Glu Cys His Ile Tyr Phe His 
            20                  25                  30


Ile Tyr Phe Ile Asn Ile 
        35


<210>  3314
<211>  669
<212>  DNA
<213>  Homo sapiens

<400>  3314
gtctgtggga attatttcct cccattggta ttagattata tttttccaag tcaactcttc     60

ctggctgccc ttcaaggttc taaagatttt ctactgttgt agtgtaacta gtaagaggca    120

aaaccatgag aatcagagag aacttccctt catgatgcta tgcaatcccc aggagaagca    180

cgttgaaagc tgaaaagaag actgactgag atgtgttggc gggcttctca agatccctat    240

cgatggcaga atgctgacat gagttgccca tagtccaggt ttcccaatgt agcagatgac    300

tctagcggct ccagcttcag catcatctta agttcaagtg aaaaggaaaa gagaatctct    360

ttttcttcaa acaatttcaa actaaaatct tgagtctgac ttttcctggc cagaattaag    420

cttgtactta tccctgaaaa atcatcaatg ctacagtgat gaatttacca attgaggcag    480

aatttaggtc acatgacgct ccaaagcctc ttcaaaaccg catgactcag agtgaggcag    540

aagtatttgg gatatttgca acaggagaag ggtaaatgaa tggagagtgc caaaacaact    600

tatgtcaatt atacaattat aaatacaacc aaaataaagt atggaaatca gtattttcac    660

ctatcttaa                                                            669


<210>  3315
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  3315

Met Asn Leu Pro Ile Glu Ala Glu Phe Arg Ser His Asp Ala Pro Lys 
1               5                   10                  15


Pro Leu Gln Asn Arg Met Thr Gln Ser Glu Ala Glu Val Phe Gly Ile 
            20                  25                  30


Phe Ala Thr Gly Glu Gly 
        35


<210>  3316
<211>  577
<212>  DNA
<213>  Homo sapiens

<400>  3316
aaaccatgag aatcagaggt aagtgcttat caaaggaata gaaccaagag gacaaattct     60

acttaaacaa tgccatcctt aaatgagaga gaacttccct tcatgatgct atgcaatccc    120

caggagaagc acgttgaaag ctgaaaagaa gactgactga gatgtgttgg cgggcttctc    180

aagatcccta tcgatggcag aatgctgaca tgagttgccc atagtccagg gactgtgttg    240

gataagaaat aaaaaagaat atgaagaaaa aacaatggtg gtgttagaga aaggacccac    300

agagtctgag aatgtgacag aagagccctt ccacgtctgg gaatgcaaca aggaacatat    360

tatatctatt tttaaatctt caaaattcct gtagtagctg agagctggaa atgctacttg    420

gattatctca ttgttggacc tcacctaaca cccagtttcc tttccctcac attgtgtact    480

tggactttgc tcctgccatt tatgtgcttc ctgcaatacc gtcatagacc accatcacct    540

ccacattcat tctccaacca ctgctaccac aatactc                             577


<210>  3317
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  3317

Met Val Val Leu Glu Lys Gly Pro Thr Glu Ser Glu Asn Val Thr Glu 
1               5                   10                  15


Glu Pro Phe His Val Trp Glu Cys Asn Lys Glu His Ile Ile Ser Ile 
            20                  25                  30


Phe Lys Ser Ser Lys Phe Leu 
        35


<210>  3318
<211>  618
<212>  DNA
<213>  Homo sapiens

<400>  3318
acagcttcca gcatgtgttg tgaaacattt cttctaattt ctaaaattga aacaattact     60

atgatctaca aaatttgaag aacaactatg aatcaataat ttactgctat aatcaacaaa    120

ggataaatta acttcatctg acacatgctg aataatctac ataaatatga ttgcaagtca    180

tggcaagtat tcgtaagtga tttgagaaag tccatgcatg ggagcaggac aaagagaaat    240

aatctgatca tccctaagag gtttcaaggt tttggtatca ggatgatgct ggcctcatgg    300

agtaagttaa ggagtctctc cttttcaatc ttttgaaata gtttcagtaa gaatggtacc    360

ctctcttctt tatatttctg gtagaatttg actgtaaatg tatatttggc tggtcctaag    420

ttttttgtgg ttggtaggct ttttattact gatttgattt cagaactcat tatttgttag    480

ttcagggatt caatttctcc cttgttcagc cttgggaaat tgtttgtttc taggaattta    540

ttaatttctt ctagattttg tcctttgtgt gcatagaggt gttcatagta gactctgaga    600

ggtgtatata tatatata                                                  618


<210>  3319
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  3319

Met Leu Asn Asn Leu His Lys Tyr Asp Cys Lys Ser Trp Gln Val Phe 
1               5                   10                  15


Val Ser Asp Leu Arg Lys Ser Met His Gly Ser Arg Thr Lys Arg Asn 
            20                  25                  30


Asn Leu Ile Ile Pro Lys Arg Phe Gln Gly Phe Gly Ile Arg Met Met 
        35                  40                  45


Leu Ala Ser Trp Ser Lys Leu Arg Ser Leu Ser Phe Ser Ile Phe 
    50                  55                  60


<210>  3320
<211>  665
<212>  DNA
<213>  Homo sapiens

<400>  3320
tttatttact agggagcagt ttccccgcgc gacagttcgg gagcgcgcag gcagtcgcgc     60

gcacacacgc acgcaggcac acacacacac acacacacac acacacacac actttcgcac    120

acacaaacac gctaggacgc tcgtcttcgc tactgcatcc ccgaaccagc agagcgaagc    180

tactgcgggt tctgttaacc tcagcatcgt ggggcgaagc agagccattg tgcatcaagg    240

agaggccggt gcctgcgctg ccgtctctgg cacctaaccc agcagaccgc tcaccccatc    300

ggctggaatg cttgctgatt cctctgcaca cttctaaggc tgagaacctg aggaacccag    360

ctggaaaatg ccgtctgaac gctgcctcag tattcaagaa atgctgacag gccagaggct    420

ctgccactcc gaatctcaca atgacagtgt cctggcagcg ctgaatcagc agaggagtga    480

tggcatcctc tgcgacatca ccctgattgc tgaggaacag aaattccatg ctcacaaggc    540

agtcctagca gcatgcagtg actatttccg gatcttgggg aacatctctt ccttcctgca    600

ggtggtcctt gagtcaccct tcttcctatc tgtcctggtt tgagtgtcag actacatgtt    660

gatgg                                                                665


<210>  3321
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  3321

Met Pro Ser Glu Arg Cys Leu Ser Ile Gln Glu Met Leu Thr Gly Gln 
1               5                   10                  15


Arg Leu Cys His Ser Glu Ser His Asn Asp Ser Val Leu Ala Ala Leu 
            20                  25                  30


Asn Gln Gln Arg Ser Asp Gly Ile Leu Cys Asp Ile Thr Leu Ile Ala 
        35                  40                  45


Glu Glu Gln Lys Phe His Ala His Lys Ala Val Leu Ala Ala Cys Ser 
    50                  55                  60


Asp Tyr Phe Arg Ile Leu Gly Asn Ile Ser Ser Phe Leu Gln Val Val 
65                  70                  75                  80


Leu Glu Ser Pro Phe Phe Leu Ser Val Leu Val 
                85                  90


<210>  3322
<211>  1952
<212>  DNA
<213>  Homo sapiens

<400>  3322
tttatttact agggagcagt ttccccgcgc gacagttcgg gagcgcgcag gcagtcgcgc     60

gcacacacgc acgcaggcac acacacacac acacacacac acacacacac actttcgcac    120

acacaaacac gctaggacgc tcgtcttcgc tactgcatcc ccgaaccagc agagcgaagc    180

tactgcgggt tctgttaacc tcagcatcgt ggggcgaagc agagccattg tgcatcaagg    240

agaggccggt gcctgcgctg ccgtctctgg cacctaaccc agcagaccgc tcaccccatc    300

ggctggaatg cttgctgatt cctctgcaca cttctaaggc tgagaacctg aggaacccag    360

ctggaaaatg ccgtctgaac gctgcctcag tattcaagaa atgctgacag gccagaggct    420

ctgccactcc gaatctcaca atgacagtgt cctggcagcg ctgaatcagc agaggagtga    480

tggcatcctc tgcgacatca ccctgattgc tgaggaacag aaattccatg ctcacaaggc    540

agtcctagca gcatgcagtg actatttccg ggcaatgttc agtctttgta tggtggaaag    600

tggagctgat gaggttaatt tgcacggtgt gaccagcctt ggcttaaagc aggctctgga    660

gtttgcatac acaggacaga ttttgctgga gccaggtgtg atccaggatg tgctagcagc    720

gggcagtcac ctacagctgt tggagcttct caatttatgc tcccactatc tcatccagga    780

attaaatagc tttaattact tggatctgta cagacttgct gacctcttta acctcacttt    840

gttggagaag gcagtgatcg atttcttagt gaaacatctc tctgaactcc tgaagagccg    900

cccagaagaa gttctaacgc ttccctattg cctgcttcag gaggtgctga agagcgaccg    960

cctgacctcc ctgagtgaag agcagatctg gcagctagct gtgaggtggt tggaacacaa   1020

ctgccactac cagtacatgg acgagctcct gcaatacatc cgctttggcc taatggatgt   1080

ggatactctc catacagttg ccctgtccca cccccttgtc caagcaagtg agactgcaac   1140

agcccttgtc aacgaggccc tggaatacca ccagagcatc tatgcacagc ctgtctggca   1200

gactcgcagg accaaaccac gattccagtc agacactctg tatatcattg gtgggaaaaa   1260

gcgcgaggtc tgcaaggtca aggaacttcg gtacttcaat cctgttgatc aggagaatgc   1320

tctcatagct gccattgcca actggagtga gctggctccc atgcctgtgg gaaggagcca   1380

ccattgtgtg gcagtcatgg gggacttcct gtttgtggca ggaggggaag ttgagcatgc   1440

cagtggccgg acgtgtgctg tgaggactgc ctgtcgctat gacccccgca gtaattcctg   1500

ggcagagata gcacccatga aaaactgccg ggagcatttt gtgctgggtg ccatggagga   1560

atacctctat gcagttgggg gcagaaatga actgcgccag gttctgccta cagttgagcg   1620

atattgcccc aagaagaaca aatggacttt tgttcagtcc tttgacagat ccctttcatg   1680

ccatgctgga tatgtggctg atggtcttct ttggatatca ggtagaacat acctcatgtt   1740

ggatttatca aaacacactt tcattgtggt atatatttaa aagtcaagct ttaatactgt   1800

ggccatgtgt aattgaaaga ttgaaccaag catgccattt tagctaatta acattcattt   1860

attgagcacc tactctagag agcaatgtaa ttggaaataa tatgcctttc tgtgactttc   1920

tgagtgacta atggaataaa aattcaaggt gg                                 1952


<210>  3323
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  3323

Met Pro Ser Glu Arg Cys Leu Ser Ile Gln Glu Met Leu Thr Gly Gln 
1               5                   10                  15


Arg Leu Cys His Ser Glu Ser His Asn Asp Ser Val Leu Ala Ala Leu 
            20                  25                  30


Asn Gln Gln Arg Ser Asp Gly Ile Leu Cys Asp Ile Thr Leu Ile Ala 
        35                  40                  45


Glu Glu Gln Lys Phe His Ala His Lys Ala Val Leu Ala Ala Cys Ser 
    50                  55                  60


Asp Tyr Phe Arg Ala Met Phe Ser Leu Cys Met Val Glu Ser Gly Ala 
65                  70                  75                  80


Asp Glu Val Asn Leu His Gly Val Thr Ser Leu Gly Leu Lys Gln Ala 
                85                  90                  95


Leu Glu Phe Ala Tyr Thr Gly Gln Ile Leu Leu Glu Pro Gly Val Ile 
            100                 105                 110


Gln Asp Val Leu Ala Ala Gly Ser His Leu Gln Leu Leu Glu Leu Leu 
        115                 120                 125


Asn Leu Cys Ser His Tyr Leu Ile Gln Glu Leu Asn Ser Phe Asn Tyr 
    130                 135                 140


Leu Asp Leu Tyr Arg Leu Ala Asp Leu Phe Asn Leu Thr Leu Leu Glu 
145                 150                 155                 160


Lys Ala Val Ile Asp Phe Leu Val Lys His Leu Ser Glu Leu Leu Lys 
                165                 170                 175


Ser Arg Pro Glu Glu Val Leu Thr Leu Pro Tyr Cys Leu Leu Gln Glu 
            180                 185                 190


Val Leu Lys Ser Asp Arg Leu Thr Ser Leu Ser Glu Glu Gln Ile Trp 
        195                 200                 205


Gln Leu Ala Val Arg Trp Leu Glu His Asn Cys His Tyr Gln Tyr Met 
    210                 215                 220


Asp Glu Leu Leu Gln Tyr Ile Arg Phe Gly Leu Met Asp Val Asp Thr 
225                 230                 235                 240


Leu His Thr Val Ala Leu Ser His Pro Leu Val Gln Ala Ser Glu Thr 
                245                 250                 255


Ala Thr Ala Leu Val Asn Glu Ala Leu Glu Tyr His Gln Ser Ile Tyr 
            260                 265                 270


Ala Gln Pro Val Trp Gln Thr Arg Arg Thr Lys Pro Arg Phe Gln Ser 
        275                 280                 285


Asp Thr Leu Tyr Ile Ile Gly Gly Lys Lys Arg Glu Val Cys Lys Val 
    290                 295                 300


Lys Glu Leu Arg Tyr Phe Asn Pro Val Asp Gln Glu Asn Ala Leu Ile 
305                 310                 315                 320


Ala Ala Ile Ala Asn Trp Ser Glu Leu Ala Pro Met Pro Val Gly Arg 
                325                 330                 335


Ser His His Cys Val Ala Val Met Gly Asp Phe Leu Phe Val Ala Gly 
            340                 345                 350


Gly Glu Val Glu His Ala Ser Gly Arg Thr Cys Ala Val Arg Thr Ala 
        355                 360                 365


Cys Arg Tyr Asp Pro Arg Ser Asn Ser Trp Ala Glu Ile Ala Pro Met 
    370                 375                 380


Lys Asn Cys Arg Glu His Phe Val Leu Gly Ala Met Glu Glu Tyr Leu 
385                 390                 395                 400


Tyr Ala Val Gly Gly Arg Asn Glu Leu Arg Gln Val Leu Pro Thr Val 
                405                 410                 415


Glu Arg Tyr Cys Pro Lys Lys Asn Lys Trp Thr Phe Val Gln Ser Phe 
            420                 425                 430


Asp Arg Ser Leu Ser Cys His Ala Gly Tyr Val Ala Asp Gly Leu Leu 
        435                 440                 445


Trp Ile Ser Gly Arg Thr Tyr Leu Met Leu Asp Leu Ser Lys His Thr 
    450                 455                 460


Phe Ile Val Val Tyr Ile 
465                 470


<210>  3324
<211>  2758
<212>  DNA
<213>  Homo sapiens

<400>  3324
tttatttact agggagcagt ttccccgcgc gacagttcgg gagcgcgcag gcagtcgcgc     60

gcacacacgc acgcaggcac acacacacac acacacacac acacacacac actttcgcac    120

acacaaacac gctaggacgc tcgtcttcgc tactgcatcc ccgaaccagc agagcgaagc    180

tactgcgggt tctgttaacc tcagcatcgt ggggcgaagc agagccattg tgcatcaagg    240

agaggccggt gcctgcgctg ccgtctctgg cacctaaccc agcagaccgc tcaccccatc    300

ggctggaatg cttgctgatt cctctgcaca cttctaaggc tgagaacctg aggaacccag    360

ctggaaaatg ccgtctgaac gctgcctcag tattcaagaa atgctgacag gccagaggct    420

ctgccactcc gaatctcaca atgacagtgt cctggcagcg ctgaatcagc agaggagtga    480

tggcatcctc tgcgacatca ccctgattgc tgaggaacag aaattccatg ctcacaaggc    540

agtcctagca gcatgcagtg actatttccg ggcaatgttc agtctttgta tggtggaaag    600

tggagctgat gaggttaatt tgcacggtgt gaccagcctt ggcttaaagc aggctctgga    660

gtttgcatac acaggacaga ttttgctgga gccaggtgtg atccaggatg tgctagcagc    720

gggcagtcac ctacagctgt tggagcttct caatttatgc tcccactatc tcatccaggt    780

ggagtaacta atacggcaca atatcagaac aggctaatgg tgtatgaacc taaccagaat    840

aagtggataa gccgtagccc catgctgcag agaagggtct accattccat ggctgctgta    900

caaaggaagc tttatgttct tggaggcaat gacctagact acaataatga ccggatcctt    960

gtgcgccata tagattctta caacatagac actgaccagt ggacacgttg taatttcaac   1020

ctgctgactg gccaaaatga atctggagtt gctgtccata atgggagaat atatttagtt   1080

ggtggatatt caatttggac aaatgagcct ctggcttgta tccaggtact ggatgtaagc   1140

agagaaggca aagaagaagt attctatggg cctacactcc cttttgcttc caatggaata   1200

gcagcatgct tccttccagc tccatatttt acatgcccta accttcaaac tcttcaagtg   1260

cctcatcaca ggattggcac catctgaaaa gccaagccat catgaacagg aggaaaacat   1320

agctctgact gttggatact gggcatgaaa agactcagtg ctccatgctt ccttgtcttg   1380

ctttataggt cttatattcg gataaattta agcaaaaaat gaacaatttt ctaaaatacg   1440

ttattgaaaa ctcgtcaccc ttctcagtgt atgtcaacat tcaatatgta tgacttttat   1500

tgtggtatag cttagtgcca atttaaggta tattgtgttc catgggtctt tagagcattc   1560

tttgtacact ttttctaatc agcactgtct taagacaaca taacactgtt agtaaggcaa   1620

tttattggac acaatggcat cgatgatctt aaaaatatat atattctgta cttaatccct   1680

ttattattta aagccgggct tgtaattttt ctttttaaaa tttaacatta tgcagccctg   1740

ctcagtagag actcactcag cattatgaca tcataaattt ttaaatgcca tattttattc   1800

aaggtgatac gaataataat agacatacac tggaacagca gttgttgaaa tacccagatt   1860

tttcaccttg gttactctga ccttgggtca gaacctaact ttacagtgct tcagttttcc   1920

caccttttaa ggaggataat tactgatttc cacgttaatt taaaagaaca ttatgaggat   1980

taggcgaaca ctttgtaata ctttgcccaa gaaaaagaaa aatgttgtta ctgaaattat   2040

aaggtatttt attgtcttta gaaccttgta attgaacagg gagattattt ttgaagttta   2100

aaaattacta gatagaattt ggaaacatgt tgtggaataa atgattctaa aaagcatgtg   2160

aaagagacac acaatgagga aatagggagt ttctcaaaat ctaaacttgt acaggtatct   2220

aaacttgcct caagtaactc tcagatgtct tatttaaaat catttagtga aaaatgacat   2280

ttaaagctaa aaaataattt agttgtacta attatggtac cataaagtgc tttgacataa   2340

atttgaacct agaattggca gttctaataa aagtttttcc actttgttaa aggttatgtc   2400

aatcttgagt gcttgtggaa ttcttcacca ccaatacata ttttattact atctctttta   2460

ataatgcata ggaattcttt tttagactag tttttgggtt tgctttgtct ataacaaaaa   2520

ataaatacaa caacttaata atcacatttg aaaacaaatt taacaagtat aatgtgagtt   2580

tttctttttt cctaacttcc tcaggaccta ggtcaccttt attaaaagga agaattcact   2640

cttttttcct tggcagttta atcattcagg aatccctctc ttaaaggaaa ttgttatttt   2700

attcatgtaa cctttttttg taatcaaaag tgaataaaaa cgatcttttt gtcttaca     2758


<210>  3325
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  3325

Met Leu Pro Leu Ser His Pro Gly Gly Val Thr Asn Thr Ala Gln Tyr 
1               5                   10                  15


Gln Asn Arg Leu Met Val Tyr Glu Pro Asn Gln Asn Lys Trp Ile Ser 
            20                  25                  30


Arg Ser Pro Met Leu Gln Arg Arg Val Tyr His Ser Met Ala Ala Val 
        35                  40                  45


Gln Arg Lys Leu Tyr Val Leu Gly Gly Asn Asp Leu Asp Tyr Asn Asn 
    50                  55                  60


Asp Arg Ile Leu Val Arg His Ile Asp Ser Tyr Asn Ile Asp Thr Asp 
65                  70                  75                  80


Gln Trp Thr Arg Cys Asn Phe Asn Leu Leu Thr Gly Gln Asn Glu Ser 
                85                  90                  95


Gly Val Ala Val His Asn Gly Arg Ile Tyr Leu Val Gly Gly Tyr Ser 
            100                 105                 110


Ile Trp Thr Asn Glu Pro Leu Ala Cys Ile Gln Val Leu Asp Val Ser 
        115                 120                 125


Arg Glu Gly Lys Glu Glu Val Phe Tyr Gly Pro Thr Leu Pro Phe Ala 
    130                 135                 140


Ser Asn Gly Ile Ala Ala Cys Phe Leu Pro Ala Pro Tyr Phe Thr Cys 
145                 150                 155                 160


Pro Asn Leu Gln Thr Leu Gln Val Pro His His Arg Ile Gly Thr Ile 
                165                 170                 175


<210>  3326
<211>  2502
<212>  DNA
<213>  Homo sapiens

<400>  3326
ggttcactgc agattatcaa tcagtggaaa gtgatagaag caatggatca gcagaatggg     60

tatagaggca atgttcagtc tttgtatggt ggaaagtgga gctgatgagg ttaatttgca    120

cggtgtgacc agccttggct taaagcaggc tctggagttt gcatacacag gacaggccat    180

gcctcttctg caagactata caacatcctt gctcctctga tgggagctgc actaatttcg    240

tgaatgtcag tcaaagcctc cttccttgag gagttggcga aagacgggtt tctctttctg    300

actagatgga aaaggagata taaagatttt tcagaataag atgagtattt tgctggagcc    360

aggtgtgatc caggatgtgc tagcagcggg cagtcaccta cagctgttgg agcttctcaa    420

tttatgctcc cactatctca tccaggaatt aaatagcttt aattacttgg atctgtacag    480

acttgctgac ctctttaacc tcactttgtt ggagaaggca gtgatcgatt tcttagtgaa    540

acatctctct gaactcctga agagccgccc agaagaagtt ctaacgcttc cctattgcct    600

gcttcaggag gtgctgaaga gcgaccgcct gacctccctg agtgaagagc agatctggca    660

ggtggagtaa ctaatacggc acaatatcag aacaggctaa tggtgtatga acctaaccag    720

aataagtgga taagccgtag ccccatgctg cagagaaggg tctaccattc catggctgct    780

gtacaaagga agctttatgt tcttggaggc aatgacctag actacaataa tgaccggatc    840

cttgtgcgcc atatagattc ttacaacata gacactgacc agtggacacg ttgtaatttc    900

aacctgctga ctggccaaaa tgaatctgga gttgctgtcc ataatgggag aatatattta    960

gttggtggat attcaatttg gacaaatgag cctctggctt gtatccaggt actggatgta   1020

agcagagaag gcaaagaaga agtattctat gggcctacac tcccttttgc ttccaatgga   1080

atagcagcat gcttccttcc agctccatat tttacatgcc ctaaccttca aactcttcaa   1140

gtgcctcatc acaggattgg caccatctga aaagccaagc catcatgaac aggaggaaaa   1200

catagctctg actgttggat actgggcatg aaaagactca gtgctccatg cttccttgtc   1260

ttgctttata ggtcttatat tcggataaat ttaagcaaaa aatgaacaat tttctaaaat   1320

acgttattga aaactcgtca cccttctcag tgtatgtcaa cattcaatat gtatgacttt   1380

tattgtggta tagcttagtg ccaatttaag gtatattgtg ttccatgggt ctttagagca   1440

ttctttgtac actttttcta atcagcactg tcttaagaca acataacact gttagtaagg   1500

caatttattg gacacaatgg catcgatgat cttaaaaata tatatattct gtacttaatc   1560

cctttattat ttaaagccgg gcttgtaatt tttcttttta aaatttaaca ttatgcagcc   1620

ctgctcagta gagactcact cagcattatg acatcataaa tttttaaatg ccatatttta   1680

ttcaaggtga tacgaataat aatagacata cactggaaca gcagttggcg aacactttgt   1740

aatactttgc ccaagaaaaa gaaaaatgtt gttactgaaa ttataaggta ttttattgtc   1800

tttagaacct tgtaattgaa cagggagatt atttttgaag tttaaaaatt actagataga   1860

atttggaaac atgttgtgga ataaatgatt ctaaaaagca tgtgaaagag acacacaatg   1920

aggaaatagg gagtttctca aaatctaaac ttgtacaggt atctaaactt gcctcaagta   1980

actctcagat gtcttattta aaatcattta gtgaaaaatg acatttaaag ctaaaaaata   2040

atttagttgt actaattatg gtaccataaa gtgctttgac ataaatttga acctagaatt   2100

ggcagttcta ataaaagttt ttccactttg ttaaaggtta tgtcaatctt gagtgcttgt   2160

ggaattcttc accaccaata catattttat tactatctct tttaataatg cataggaatt   2220

cttttttaga ctagtttttg ggtttgcttt gtctataaca aaaaataaat acaacaactt   2280

aataatcaca tttgaaaaca aatttaacaa gtataatgtg agtttttctt ttttcctaac   2340

ttcctcagga cctaggtcac ctttattaaa aggaagaatt cactcttttt tccttggcag   2400

tttaatcatt caggaatccc tctcttaaag gaaattgtta ttttattcat gtaacctttt   2460

tttgtaatca aaagtgaata aaaacgatct ttttgtctta ca                      2502


<210>  3327
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  3327

Met Val Tyr Glu Pro Asn Gln Asn Lys Trp Ile Ser Arg Ser Pro Met 
1               5                   10                  15


Leu Gln Arg Arg Val Tyr His Ser Met Ala Ala Val Gln Arg Lys Leu 
            20                  25                  30


Tyr Val Leu Gly Gly Asn Asp Leu Asp Tyr Asn Asn Asp Arg Ile Leu 
        35                  40                  45


Val Arg His Ile Asp Ser Tyr Asn Ile Asp Thr Asp Gln Trp Thr Arg 
    50                  55                  60


Cys Asn Phe Asn Leu Leu Thr Gly Gln Asn Glu Ser Gly Val Ala Val 
65                  70                  75                  80


His Asn Gly Arg Ile Tyr Leu Val Gly Gly Tyr Ser Ile Trp Thr Asn 
                85                  90                  95


Glu Pro Leu Ala Cys Ile Gln Val Leu Asp Val Ser Arg Glu Gly Lys 
            100                 105                 110


Glu Glu Val Phe Tyr Gly Pro Thr Leu Pro Phe Ala Ser Asn Gly Ile 
        115                 120                 125


Ala Ala Cys Phe Leu Pro Ala Pro Tyr Phe Thr Cys Pro Asn Leu Gln 
    130                 135                 140


Thr Leu Gln Val Pro His His Arg Ile Gly Thr Ile 
145                 150                 155


<210>  3328
<211>  502
<212>  DNA
<213>  Homo sapiens

<400>  3328
agctgtaagc tgtccgcgag ggaggtgatc tcctgggccg agggcttggg gcatttgagg     60

aaatggctct ccagagcccc cttgacgctc acctcgatgg agttgctgtg agtagtacca    120

ccagtacaat gttgaacaga agtggtgaga gtaacagaga ggcccaagaa gagggagaaa    180

gatggaggag tggctgtttg atggaagagt cagaaaacac acaacatttg ttggttgagt    240

ttgccatctt attggtctgg aactgagcct gccgtgtctc ccaggtacac ctgtgcctac    300

tatgtgttat cagggattca aagattagga cagaaatgag aaaagccaga cttcgaagcc    360

taattttcag gggctcacat cacttctgtt cctgtgtcgt gggaccatcc agcagcagca    420

cataattgaa agtcatctga ctcacaggat tgggagtgaa cctggcaggc cctggaacag    480

atcttcactg actggcatgt gt                                             502


<210>  3329
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  3329

Met Ala Leu Gln Ser Pro Leu Asp Ala His Leu Asp Gly Val Ala Val 
1               5                   10                  15


Ser Ser Thr Thr Ser Thr Met Leu Asn Arg Ser Gly Glu Ser Asn Arg 
            20                  25                  30


Glu Ala Gln Glu Glu Gly Glu Arg Trp Arg Ser Gly Cys Leu Met Glu 
        35                  40                  45


Glu Ser Glu Asn Thr Gln His Leu Leu Val Glu Phe Ala Ile Leu Leu 
    50                  55                  60


Val Trp Asn 
65


<210>  3330
<211>  2941
<212>  DNA
<213>  Homo sapiens

<400>  3330
gaggcagctg cggggggagc cggcggccgc tgctgccgcc cagggctctg gggccccgcc     60

ggccaggccc gccgtccgcg gccagtgccc ttcctcctcc tcctcctctg ccgccgcctc    120

ctcagtcgcc gccgcctcct cagtcgccgc cgcccgcgcc gcccgcgccc tccgcgcgcc    180

tctgagcccg cgccgggccg cgccggcccc ttcccatgcg ggcggcgcgg gccctgggag    240

gggcgcccgg agccagccgc gcagcatgca ctggggggtt ggctttgctt cgtccaggcc    300

gtgcgtggtg gatctgagct ggaaccagag catctccttc ttcggctggt gggccgggtc    360

cgaggagccc ttctcctttt atggggacat catcgctttc cctttgcagg attacggtgg    420

gatcatggca gggctgggct ccgatccctg gtggaagaaa accctttact tgaccggggg    480

agctttgctg gccgcagctg cgtatctgct ccacgaactc ctggtcatta ggaaacagca    540

agagattgac tctaaagatg ctattatttt gcatcagttt gcaagaccta acaatggtgt    600

tccaagttta tctcctttct gtttaaagat ggaaacttat ttaaggatgg ctgacttacc    660

gtatcagaac tattttggtg gaaaactctc tgctcaaggg aaaatgcctt ggattgaata    720

taatcatgaa aaagtttctg gcacagaatt cataattgac tttctggaag agaagcttgg    780

agtgaattta aacaaaaacc ttggccctca tgaaagagcc atctccagag cggtgaccaa    840

gatggtggag gagcacttct actggacatt agcttattgc cagtgggtgg acaatctcaa    900

tgagacccgg aagatgctct ctcttagtgg tggtggtccc ttcagcaacc tgctgaggtg    960

ggttgtgtgc cacataacga aaggaattgt gaaacgcgag atgcacggcc acggcattgg   1020

ccgcttctcc gaggaagaga tttacatgct gatggagaag gacatgcggt ctttagcagg   1080

gcttttgggt gataagaagt acatcatggg gcccaagctt tccactcttg acgccactgt   1140

ctttggacac ttggcacagg caatgtggac cttaccaggg acaagacccg aacggctgat   1200

caaaggtgag ctgatcaacc ttgccatgta ctgtgagagg ataaggagga aattttggcc   1260

agagtggcac cacgatgatg acaataccat ctatgagtct gaggagagca gcgaaggcag   1320

caaaacccac accccgctgc tggattttag cttttactca aggacagaga cctttgaaga   1380

tgagggagca gaaaacagtt tttccagaac cccagacaca gattttactg gacactcact   1440

ctttgattcg gatgtggaca tggatgacta tacagaccac gaacagtgca agtgacgtcc   1500

agcctcactg accctcttcc ttgggacctg ccactccctg ggtcggtcca ttttcccagg   1560

tagcaatcca tccgagctgg gaggagatct tcgtgcttgg cagagttttc acatgctaac   1620

tggactatag cagccttatt tcttttttgt acaaacaaaa cacagaacca ttcagatgac   1680

tccattgaaa acaaacaggc aaaaaataat gtcagcatgg ttcctgaaat ccatttttgt   1740

tttcattaga aaactattaa taatattgtg tggtagagca ggtgtaagag ctggttgtca   1800

gctgatagtt tttatgatga tcctcttcaa ccctgaggtc ttaattgtga gatggattct   1860

tgaacctcct tcctccacca ggatttgaag taatgagaga tatcatcaga aaaatgtttt   1920

acggtggctg cttgtacttt atgtgtgtat attgtatgtt gagacataag tcaaataact   1980

cttagaagtg gtgcgacata aacacagcat tttattcttt attgcacttc atgcatgtga   2040

agatttgagg gcaaaggaat tccatatcca ggcaaccacc accacagtca cctgcaaaag   2100

ctgagcagat gaaatacaca caaaggtaca cttaggactt tgtcatgatt cctttctgta   2160

atcttggctg aatcaaaatc ttttgttcaa agaacattgg aaatgttttt acaaattatc   2220

gacagctaca aacagtcttc aattctacca tgtatttgca gaaaagtggt tctttcattg   2280

cctgaactca ccctggcatg ttctgtgttg actccagagt gttacgttgc ctatgtttga   2340

tttatttgag aagaataaat ctcaggtata tggcaggttt catagagttg aagggaaagt   2400

atttcattga tttttataag cagaagcctg ccaacttgta atgtcttttt gaaaacaaac   2460

cttgcaaaga tgtattgaaa agatgaagta gcaagaggat acttgtatca aagcactctg   2520

tgcagtgtta gactatatgc agttttatta atgcaacttt tctggtgttt tcagccactg   2580

cccagtgaga ggagagcaat gctgagaaca agtcttaatg tttttgctgt ctcatccccg   2640

ttctctctct ctttccctat agtattcgat gaactgttgg cttacccata tttgtgaagg   2700

caccctattt ctaaagatga agttgttgtt gttgttgttg ttttgactta ggacattttc   2760

cagggaaata tggggcagag atcctgggtg atggctgtga gatttgggct aggagagcca   2820

agatttacaa ttgcaaacaa aactgctttg cttctgacca acataaggat tgctcattat   2880

ggggttaaag aggcacttct taaaatacag caacttctga gaaatccatg cactttactt   2940

g                                                                   2941


<210>  3331
<211>  409
<212>  PRT
<213>  Homo sapiens

<400>  3331

Met His Trp Gly Val Gly Phe Ala Ser Ser Arg Pro Cys Val Val Asp 
1               5                   10                  15


Leu Ser Trp Asn Gln Ser Ile Ser Phe Phe Gly Trp Trp Ala Gly Ser 
            20                  25                  30


Glu Glu Pro Phe Ser Phe Tyr Gly Asp Ile Ile Ala Phe Pro Leu Gln 
        35                  40                  45


Asp Tyr Gly Gly Ile Met Ala Gly Leu Gly Ser Asp Pro Trp Trp Lys 
    50                  55                  60


Lys Thr Leu Tyr Leu Thr Gly Gly Ala Leu Leu Ala Ala Ala Ala Tyr 
65                  70                  75                  80


Leu Leu His Glu Leu Leu Val Ile Arg Lys Gln Gln Glu Ile Asp Ser 
                85                  90                  95


Lys Asp Ala Ile Ile Leu His Gln Phe Ala Arg Pro Asn Asn Gly Val 
            100                 105                 110


Pro Ser Leu Ser Pro Phe Cys Leu Lys Met Glu Thr Tyr Leu Arg Met 
        115                 120                 125


Ala Asp Leu Pro Tyr Gln Asn Tyr Phe Gly Gly Lys Leu Ser Ala Gln 
    130                 135                 140


Gly Lys Met Pro Trp Ile Glu Tyr Asn His Glu Lys Val Ser Gly Thr 
145                 150                 155                 160


Glu Phe Ile Ile Asp Phe Leu Glu Glu Lys Leu Gly Val Asn Leu Asn 
                165                 170                 175


Lys Asn Leu Gly Pro His Glu Arg Ala Ile Ser Arg Ala Val Thr Lys 
            180                 185                 190


Met Val Glu Glu His Phe Tyr Trp Thr Leu Ala Tyr Cys Gln Trp Val 
        195                 200                 205


Asp Asn Leu Asn Glu Thr Arg Lys Met Leu Ser Leu Ser Gly Gly Gly 
    210                 215                 220


Pro Phe Ser Asn Leu Leu Arg Trp Val Val Cys His Ile Thr Lys Gly 
225                 230                 235                 240


Ile Val Lys Arg Glu Met His Gly His Gly Ile Gly Arg Phe Ser Glu 
                245                 250                 255


Glu Glu Ile Tyr Met Leu Met Glu Lys Asp Met Arg Ser Leu Ala Gly 
            260                 265                 270


Leu Leu Gly Asp Lys Lys Tyr Ile Met Gly Pro Lys Leu Ser Thr Leu 
        275                 280                 285


Asp Ala Thr Val Phe Gly His Leu Ala Gln Ala Met Trp Thr Leu Pro 
    290                 295                 300


Gly Thr Arg Pro Glu Arg Leu Ile Lys Gly Glu Leu Ile Asn Leu Ala 
305                 310                 315                 320


Met Tyr Cys Glu Arg Ile Arg Arg Lys Phe Trp Pro Glu Trp His His 
                325                 330                 335


Asp Asp Asp Asn Thr Ile Tyr Glu Ser Glu Glu Ser Ser Glu Gly Ser 
            340                 345                 350


Lys Thr His Thr Pro Leu Leu Asp Phe Ser Phe Tyr Ser Arg Thr Glu 
        355                 360                 365


Thr Phe Glu Asp Glu Gly Ala Glu Asn Ser Phe Ser Arg Thr Pro Asp 
    370                 375                 380


Thr Asp Phe Thr Gly His Ser Leu Phe Asp Ser Asp Val Asp Met Asp 
385                 390                 395                 400


Asp Tyr Thr Asp His Glu Gln Cys Lys 
                405


<210>  3332
<211>  915
<212>  DNA
<213>  Homo sapiens

<400>  3332
ggtagtgcaa tactattaat tcccaggcca tgctgtcagc tcatcagtag agagttgagt     60

ggaggtgaag ggcatgagga ctaacgaggt taatatgaat tcaacaggtg agctgatcaa    120

ccttgccatg tactgtgaga ggataaggag gaaattttgg ccagagtggc accacgatga    180

tgacaatacc atctatgagt ctgaggagag cagcgaaggc agcaaaaccc acaccccgct    240

gctggatttt agcttttact caaggacaga gacctttgaa gatgagggag cagaaaacag    300

tttttccaga accccagaca cagattttac tggacactca ctctttgatt cggatgtgga    360

catggatgac tatacagacc acgaacagtg caagtgacgt ccagcctcac tgaccctctt    420

ccttgggacc tgccactccc tgggtcggtc cattttccca ggtagcaatc catccgagct    480

gggaggagat cttcgtgctt ggcagagttt tcacatgcta actggactat agcagcctta    540

tttctttttt gtacaaacaa aacacagaac cattcagatg actccattga aaacaaacag    600

gcaaaaaata atgtcagcat ggttcctgaa atccattttt gttttcatta gaaaactatt    660

aataatattg tgtggtagag caggtgtaag agctggttgt cagctgatag tttttatgat    720

gatcctcttc aaccctgagg tcttaattgt gagatggatt cttgaacctc cttcctccac    780

caggatttga agtaatgaga gatatcatca gaaaaatgtt ttacggtggc tgcttgtact    840

ttatgtgtgt atattgtatg ttgagacata agtcaaataa aatccacaga tattaaacga    900

acacctacta tgtgc                                                     915


<210>  3333
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  3333

Met Arg Thr Asn Glu Val Asn Met Asn Ser Thr Gly Glu Leu Ile Asn 
1               5                   10                  15


Leu Ala Met Tyr Cys Glu Arg Ile Arg Arg Lys Phe Trp Pro Glu Trp 
            20                  25                  30


His His Asp Asp Asp Asn Thr Ile Tyr Glu Ser Glu Glu Ser Ser Glu 
        35                  40                  45


Gly Ser Lys Thr His Thr Pro Leu Leu Asp Phe Ser Phe Tyr Ser Arg 
    50                  55                  60


Thr Glu Thr Phe Glu Asp Glu Gly Ala Glu Asn Ser Phe Ser Arg Thr 
65                  70                  75                  80


Pro Asp Thr Asp Phe Thr Gly His Ser Leu Phe Asp Ser Asp Val Asp 
                85                  90                  95


Met Asp Asp Tyr Thr Asp His Glu Gln Cys Lys 
            100                 105


<210>  3334
<211>  854
<212>  DNA
<213>  Homo sapiens

<400>  3334
agaacaattg ctgatattgt ggtatgtatg taatctttta tcaaatgtga gctgatcaac     60

cttgccatgt actgtgagag gataaggagg aaattttggc cagagtggca ccacgatgat    120

gacaatacca tctatgagtc tgaggagagc agcgaaggca gcaaaaccca caccccgctg    180

ctggatttta gcttttactc aaggacagag acctttgaag atgagggagc agaaaacagt    240

ttttccagaa ccccagacac agattttact ggacactcac tctttgattc ggatgtggac    300

atggatgact atacagacca cgaacagtgc aagtgacgtc cagcctcact gaccctcttc    360

cttgggacct gccactccct gggtcggtcc attttcccag gtagcaatcc atccgagctg    420

ggaggagatc ttcgtgcttg gcagagtttt cacatgctaa ctggactata gcagccttat    480

ttcttttttg tacaaacaaa acacagaacc attcagatga ctccattgaa aacaaacagg    540

caaaaaataa tgtcagcatg gttcctgaaa tccatttttg ttttcattag aaaactatta    600

ataatattgt gtggtagagc aggtgtaaga gctggttgtc agctgatagt ttttatgatg    660

atcctcttca accctgaggt cttaattgtg agatggattc ttgaacctcc ttcctccacc    720

aggatttgaa gtaatgagag atatcatcag aaaaatgttt tacggtggct gcttgtactt    780

tatgtgtgta tattgtatgt tgagacataa gtcaaataaa atccacagat attaaacgaa    840

cacctactat gtgc                                                      854


<210>  3335
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  3335

Met Tyr Cys Glu Arg Ile Arg Arg Lys Phe Trp Pro Glu Trp His His 
1               5                   10                  15


Asp Asp Asp Asn Thr Ile Tyr Glu Ser Glu Glu Ser Ser Glu Gly Ser 
            20                  25                  30


Lys Thr His Thr Pro Leu Leu Asp Phe Ser Phe Tyr Ser Arg Thr Glu 
        35                  40                  45


Thr Phe Glu Asp Glu Gly Ala Glu Asn Ser Phe Ser Arg Thr Pro Asp 
    50                  55                  60


Thr Asp Phe Thr Gly His Ser Leu Phe Asp Ser Asp Val Asp Met Asp 
65                  70                  75                  80


Asp Tyr Thr Asp His Glu Gln Cys Lys 
                85


<210>  3336
<211>  899
<212>  DNA
<213>  Homo sapiens

<400>  3336
ggtagtgcaa tactattaat tcccaggcca tgctgtcagc tcatcagtag agagttgagt     60

ggaggtgaag ggcatgagga ctaacgaggt taatatgaat tcaacaggtg agctgatcaa    120

ccttgccatg tactgtgaga ggataaggag gaaattttgg ccagagtggc accacgatga    180

tgacaatacc atctatgagt ctgaggagag cagcgaaggc agcaaaaccc acaccccgct    240

gctggatttt agcttttact caaggacaga gacctttgaa gatgagggag cagaaaacag    300

tttttccaga accccagaca cagattttac tggacactca ctctttgatt cggatgtgga    360

catggatgac tatacagacc acgaacagtg caagtgacgt ccagcctcac tgaccctctt    420

ccttgggacc tgccactccc tgggtcggtc cattttccca ggtagcaatc catccgagct    480

gggaggagat cttcgtgctt ggcagagttt tcacatgcta actggactat agcagcctta    540

tttctttttt gtacaaacaa aacacagaac cattcagatg actccattga aaacaaacag    600

gcaaaaaata atgtcagcat ggttcctgaa atccattttt gttttcatta gaaaactatt    660

aataatattg tgtggtagag caggtgtaag agctggttgt cagctgatag tttttatgat    720

gatcctcttc aaccctgagg tcttaattgt gagatggatt cttgaacctc cttcctccac    780

caggatttga agtaatgaga gatatcatca gaaaaatgtt ttacggtggc tgcttgtact    840

ttatgtgtgt atattgtatg ttgagacata agtcaaataa aatccacaga tattaaacg     899


<210>  3337
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  3337

Met Arg Thr Asn Glu Val Asn Met Asn Ser Thr Gly Glu Leu Ile Asn 
1               5                   10                  15


Leu Ala Met Tyr Cys Glu Arg Ile Arg Arg Lys Phe Trp Pro Glu Trp 
            20                  25                  30


His His Asp Asp Asp Asn Thr Ile Tyr Glu Ser Glu Glu Ser Ser Glu 
        35                  40                  45


Gly Ser Lys Thr His Thr Pro Leu Leu Asp Phe Ser Phe Tyr Ser Arg 
    50                  55                  60


Thr Glu Thr Phe Glu Asp Glu Gly Ala Glu Asn Ser Phe Ser Arg Thr 
65                  70                  75                  80


Pro Asp Thr Asp Phe Thr Gly His Ser Leu Phe Asp Ser Asp Val Asp 
                85                  90                  95


Met Asp Asp Tyr Thr Asp His Glu Gln Cys Lys 
            100                 105


<210>  3338
<211>  838
<212>  DNA
<213>  Homo sapiens

<400>  3338
agaacaattg ctgatattgt ggtatgtatg taatctttta tcaaatgtga gctgatcaac     60

cttgccatgt actgtgagag gataaggagg aaattttggc cagagtggca ccacgatgat    120

gacaatacca tctatgagtc tgaggagagc agcgaaggca gcaaaaccca caccccgctg    180

ctggatttta gcttttactc aaggacagag acctttgaag atgagggagc agaaaacagt    240

ttttccagaa ccccagacac agattttact ggacactcac tctttgattc ggatgtggac    300

atggatgact atacagacca cgaacagtgc aagtgacgtc cagcctcact gaccctcttc    360

cttgggacct gccactccct gggtcggtcc attttcccag gtagcaatcc atccgagctg    420

ggaggagatc ttcgtgcttg gcagagtttt cacatgctaa ctggactata gcagccttat    480

ttcttttttg tacaaacaaa acacagaacc attcagatga ctccattgaa aacaaacagg    540

caaaaaataa tgtcagcatg gttcctgaaa tccatttttg ttttcattag aaaactatta    600

ataatattgt gtggtagagc aggtgtaaga gctggttgtc agctgatagt ttttatgatg    660

atcctcttca accctgaggt cttaattgtg agatggattc ttgaacctcc ttcctccacc    720

aggatttgaa gtaatgagag atatcatcag aaaaatgttt tacggtggct gcttgtactt    780

tatgtgtgta tattgtatgt tgagacataa gtcaaataaa atccacagat attaaacg      838


<210>  3339
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  3339

Met Tyr Cys Glu Arg Ile Arg Arg Lys Phe Trp Pro Glu Trp His His 
1               5                   10                  15


Asp Asp Asp Asn Thr Ile Tyr Glu Ser Glu Glu Ser Ser Glu Gly Ser 
            20                  25                  30


Lys Thr His Thr Pro Leu Leu Asp Phe Ser Phe Tyr Ser Arg Thr Glu 
        35                  40                  45


Thr Phe Glu Asp Glu Gly Ala Glu Asn Ser Phe Ser Arg Thr Pro Asp 
    50                  55                  60


Thr Asp Phe Thr Gly His Ser Leu Phe Asp Ser Asp Val Asp Met Asp 
65                  70                  75                  80


Asp Tyr Thr Asp His Glu Gln Cys Lys 
                85


<210>  3340
<211>  1996
<212>  DNA
<213>  Homo sapiens

<400>  3340
cacaaagagc ggggcggaga ggcagctgcg gggggagccg gcggccgctg ctgccgccca     60

gggctctggg gccccgccgg ccaggcccgc cgtccgcggc cagtgccctt cctcctcctc    120

ctcctctgcc gccgcctcct cagtcgccgc cgcctcctca gtcgccgccg cccgcgccgc    180

ccgcgccctc cgcgcgcctc tgagcccgcg ccgggccgcg ccggcccctt cccatgcggg    240

cggcgcgggc cctgggaggg gcgcccggag ccagccgcgc agcatgcact ggggggttgg    300

ctttgcttcg tccaggccgt gcgtggtgga tctgagctgg aaccagagca tctccttctt    360

cggctggtgg gccgggtccg aggagccctt ctccttttat ggggacatca tcgctttccc    420

tttgcaggat tacggtggga tcatggcagg gctgggctcc gatccctggt ggaagaaaac    480

cctttacttg accgggggag ctttgctggc cgcagctgcg tatctgctcc acgaactcct    540

ggtcattagg aaacagcaag agattgactc taaagatgct attattttgc atcagtttgc    600

aagacctaac aatggtgttc caagtttatc tcctttctgt ttaaagatgg aaacttattt    660

aaggatggct gacttaccgt atcagaacta ttttggtgga aaactctctg ctcaagggaa    720

aatgccttgg attgaatata atcatgaaaa agtttctggc acagaattca taattgactt    780

tctggaagag aagcttggag tgaatttaaa caaaaacctt ggccctcatg aaagagccat    840

ctccagagcg gtgaccaaga tggtggagga gcacttctac tggacattag cttattgcca    900

gtgggtggac aatctcaatg agacccggaa gatgctctct cttagtggtg gtggtccctt    960

cagcaacctg ctgaggtggg ttgtgtgcca cataacgaaa ggaattgtga aacgcgagat   1020

gcacggccac ggcattggcc gcttctccga ggaagagatt tacatgctga tggagaagga   1080

catgcggtct ttagcagggc ttttgggtga taagaagtac atcatggggc ccaagctttc   1140

cactcttgac gccactgtct ttggacactt ggcacaggca atgtggacct taccagggac   1200

aagacccgaa cggctgatca aaggtgagct gatcaacctt gccatgtact gtgagaggat   1260

aaggaggaaa ttttggccag agtggcacca cgatgatgac aataccatct atgagtctga   1320

ggagagcagc gaaggcagca aaacccacac cccgctgctg gattttagct tttactcaag   1380

gacagagacc tttgaagatg agggagcaga aaacagtttt tccagaaccc cagacacaga   1440

ttttactgga cactcactct ttgattcgga tgtggacatg gatgactata cagaccacga   1500

acagtgcaag tgacgtccag cctcactgac cctcttcctt gggacctgcc actccctggg   1560

tcggtccatt ttcccaggta gcaatccatc cgagctggga ggagatcttc gtgcttggca   1620

gagttttcac atgctaactg gactatagca gccttatttc ttttttgtac aaacaaaaca   1680

cagaaccatt cagatgactc cattgaaaac aaacaggcaa aaaataatgt cagcatggtt   1740

cctgaaatcc atttttgttt tcattagaaa actattaata atattgtgtg gtagagcagg   1800

tgtaagagct ggttgtcagc tgatagtttt tatgatgatc ctcttcaacc ctgaggtctt   1860

aattgtgaga tggattcttg aacctccttc ctccaccagg atttgaagta atgagagata   1920

tcatcagaaa aatgttttac ggtggctgct tgtactttat gtgtgtatat tgtatgttga   1980

gacataagtc aaataa                                                   1996


<210>  3341
<211>  409
<212>  PRT
<213>  Homo sapiens

<400>  3341

Met His Trp Gly Val Gly Phe Ala Ser Ser Arg Pro Cys Val Val Asp 
1               5                   10                  15


Leu Ser Trp Asn Gln Ser Ile Ser Phe Phe Gly Trp Trp Ala Gly Ser 
            20                  25                  30


Glu Glu Pro Phe Ser Phe Tyr Gly Asp Ile Ile Ala Phe Pro Leu Gln 
        35                  40                  45


Asp Tyr Gly Gly Ile Met Ala Gly Leu Gly Ser Asp Pro Trp Trp Lys 
    50                  55                  60


Lys Thr Leu Tyr Leu Thr Gly Gly Ala Leu Leu Ala Ala Ala Ala Tyr 
65                  70                  75                  80


Leu Leu His Glu Leu Leu Val Ile Arg Lys Gln Gln Glu Ile Asp Ser 
                85                  90                  95


Lys Asp Ala Ile Ile Leu His Gln Phe Ala Arg Pro Asn Asn Gly Val 
            100                 105                 110


Pro Ser Leu Ser Pro Phe Cys Leu Lys Met Glu Thr Tyr Leu Arg Met 
        115                 120                 125


Ala Asp Leu Pro Tyr Gln Asn Tyr Phe Gly Gly Lys Leu Ser Ala Gln 
    130                 135                 140


Gly Lys Met Pro Trp Ile Glu Tyr Asn His Glu Lys Val Ser Gly Thr 
145                 150                 155                 160


Glu Phe Ile Ile Asp Phe Leu Glu Glu Lys Leu Gly Val Asn Leu Asn 
                165                 170                 175


Lys Asn Leu Gly Pro His Glu Arg Ala Ile Ser Arg Ala Val Thr Lys 
            180                 185                 190


Met Val Glu Glu His Phe Tyr Trp Thr Leu Ala Tyr Cys Gln Trp Val 
        195                 200                 205


Asp Asn Leu Asn Glu Thr Arg Lys Met Leu Ser Leu Ser Gly Gly Gly 
    210                 215                 220


Pro Phe Ser Asn Leu Leu Arg Trp Val Val Cys His Ile Thr Lys Gly 
225                 230                 235                 240


Ile Val Lys Arg Glu Met His Gly His Gly Ile Gly Arg Phe Ser Glu 
                245                 250                 255


Glu Glu Ile Tyr Met Leu Met Glu Lys Asp Met Arg Ser Leu Ala Gly 
            260                 265                 270


Leu Leu Gly Asp Lys Lys Tyr Ile Met Gly Pro Lys Leu Ser Thr Leu 
        275                 280                 285


Asp Ala Thr Val Phe Gly His Leu Ala Gln Ala Met Trp Thr Leu Pro 
    290                 295                 300


Gly Thr Arg Pro Glu Arg Leu Ile Lys Gly Glu Leu Ile Asn Leu Ala 
305                 310                 315                 320


Met Tyr Cys Glu Arg Ile Arg Arg Lys Phe Trp Pro Glu Trp His His 
                325                 330                 335


Asp Asp Asp Asn Thr Ile Tyr Glu Ser Glu Glu Ser Ser Glu Gly Ser 
            340                 345                 350


Lys Thr His Thr Pro Leu Leu Asp Phe Ser Phe Tyr Ser Arg Thr Glu 
        355                 360                 365


Thr Phe Glu Asp Glu Gly Ala Glu Asn Ser Phe Ser Arg Thr Pro Asp 
    370                 375                 380


Thr Asp Phe Thr Gly His Ser Leu Phe Asp Ser Asp Val Asp Met Asp 
385                 390                 395                 400


Asp Tyr Thr Asp His Glu Gln Cys Lys 
                405


<210>  3342
<211>  638
<212>  DNA
<213>  Homo sapiens

<400>  3342
agatgcaacc ccaggagacg tccctgtggc agccagtgtc agctgcttcc ttccccagcg     60

ttttgcttca gccctcactc ctcagccact tccactgctc ctgtggttag tgaccgcctc    120

tgcctcctcc actacccgga cagcttggtg aatacttcca gggaaaattc tgcttaaatt    180

ccgctggtgg catgcccata agcatttcca gatctgaagg cgcttgcgcc tttcctagta    240

ctctactgtc cacagggcca cagagtctca actgctggat attgtccaag tcctcttcat    300

tgcagctgtg atggctacac ggccaggcct ggctcggagg cacaaagccg gttttttgtg    360

tgaccacaga aaggtcatcc caacactgaa ttttatcacc ccttggggag atgctaacat    420

aggagtcaaa atagcgaagg tttaaggtga gaggcgcgct cccggttaca ggtatccgtg    480

gtcattcttc tgaatctcta gaaatcggac tcaggcgctc ctctctttgg ggctcctcgc    540

aggcgactgc atttgctgcg cggcgcggcc aggcgggtcc ttagcgccgg caccgtcgcc    600

ctcggcatcc cacagcgcgc agcgcagcca ccgctctt                            638


<210>  3343
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  3343

Met Ala Thr Arg Pro Gly Leu Ala Arg Arg His Lys Ala Gly Phe Leu 
1               5                   10                  15


Cys Asp His Arg Lys Val Ile Pro Thr Leu Asn Phe Ile Thr Pro Trp 
            20                  25                  30


Gly Asp Ala Asn Ile Gly Val Lys Ile Ala Lys Val 
        35                  40


<210>  3344
<211>  3848
<212>  DNA
<213>  Homo sapiens

<400>  3344
cacaaggcag aagaagtgtt ctatgcagtc aaagttttac agaagaaagc aatcctgaaa     60

aagaaagagg tatgagatgt gcttgatggg gctggcattg gcggtagaca ctccttgaat    120

aatcttgatt ctggaatgtt ggtgccaagt tgaaacatgc cactaaatct gaatcgtcat    180

tttcctagga gaagcatatt atgtcggagc ggaatgttct gttgaagaat gtgaagcacc    240

ctttcctggt gggccttcac ttctctttcc agactgctga caaattgtac tttgtcctag    300

actacattaa tggtggagag ttgttctacc atctccagag ggaacgctgc ttcctggaac    360

cacgggctcg tttctatgct gctgaaatag ccagtgcctt gggctacctg cattcactga    420

acatcgttta taggtaagcc tgagagctct tcaggctacc agttttggta taaaggagac    480

gtagcactgg ctgtttcata gggccttaaa ataatttgtg tttatttgca acttggttgc    540

ctaaaaccag atcccctagc acgtgagctg gcttgactta agtgccaagg gggaaccagc    600

caagtaggat tgtgcctaat ccagaataga tgagcagaac aagggctccc ttttttcttc    660

actacacaac tacagtgaac ctaaaatgcc tctaatacct ttagcaatta tctttaagag    720

gatatcttat gaagtgaaat taacttgtgc aactactttt ctattcactt ttttacagag    780

acttaaaacc agagaatatt ttgctagatt cacagggaca cattgtcctt actgacttcg    840

gactctgcaa ggagaacatt gaacacaaca gcacaacatc caccttctgt ggcacgccgg    900

aggtaggcgc tgtcttggtt tggtgcctgg tttacccccg ccttccaaga gagagatgta    960

caatcatgca cttaactacc aaaaagagta aactcctctc agagacttct taatacagtt   1020

cagtgcaaat aaaatacatt tgctgtttga tgtagcatga gaaatcccaa gtccttctgt   1080

tcctttactg aaaagtagct gtttgtaagt aagatctgca tcataaaaac tttctaaatc   1140

cctaagtaag agatatcaag tgcccagcag tttcctaaat gtcagtacac ataggtagcc   1200

agtcaccctc aaaaagtcca gcagttttat caggaaggaa tctaaagata tctatcttcc   1260

aagctggctc tgggtctctc agctttttca aactaaatgt gtggtcgtgg gattgcttgc   1320

tttcgcaggt tctaaacgct gtttccctgg tctgtttttc agtatctcgc acctgaggtg   1380

cttcataagc agccttatga caggactgtg gactggtggt gcctgggagc tgtcttgtat   1440

gagatgctgt atggcctggt gagtggcaca ttgggaacca tggaacactg cctgctccct   1500

acaatattgc cttcacacag cccatgcttg gccatggtgt cttgccctta ccagtacgct   1560

tatcaaaagc agctaagagg catattggtt attttatagt tcataagaat aatcacttac   1620

ctggttcttt tgtgcatttc acattttact agataggacc acattgaacc tgtgtggtgg   1680

tgaaaaacta ccacttatta acatctaccc cctcaccctc cacacacaca cacacaaaca   1740

cacacacggg ttgcaaagta gacacttaaa tagcaaggga aaagaaagca ttgaggtggg   1800

gagagtttct caaatcgagc ctaatattta ttgccgttta tatctttttc tctactggta   1860

atgtgtgcca tatgaaactt ccaattaagt ctaaagtaat tttccccttc tttcagccgc   1920

ctttttatag ccgaaacaca gctgaaatgt acgacaacat tctgaacaag cctctccagc   1980

tgaaaccaaa tattacaaat tccgcaagac acctcctgga gggcctcctg cagaaggaca   2040

ggacaaagcg gctcggggcc aaggatgact tcgtgagtga tgttttcctg tcctcctggg   2100

ccggccggga cgtgcactag acctccctgc ccttattgaa tgcacctgtc taaattaatc   2160

ttgggtttct tatcaacaga tggagattaa gagtcatgtc ttcttctcct taattaactg   2220

ggatgatctc attaataaga agattactcc cccttttaac ccaaatgtgg tgagtatctg   2280

tctctcttct aagtatagag aagcccaaag ggcatttatt ttaattcaga attgtctggg   2340

ggagggttgg aaggaataca ttggcagatg ttttctccat aaacctgtta ttttacctac   2400

ataaaaagca catttttgtg tcccaacaag gctcccataa tttttagaca catttatcaa   2460

ttcgaagcac caaaaggcaa caagtgaaca ttattcttat gtttaactgt gtgtagcctt   2520

ttgagatttt gtgcttgaag tgggtgatta tggaagttga tataagactt aaacttggta   2580

tttaaagcct ggtcaagatt tccctgtcct gtgtctagtg tgagttcttg acaagagtgt   2640

ttttcccttc ccgtcacaga gtgggcccaa cgacctacgg cactttgacc ccgagtttac   2700

cgaagagcct gtccccaact ccattggcaa gtcccctgac agcgtcctcg tcacagccag   2760

cgtcaaggaa gctgccgagg ctttcctagg cttttcctat gcgcctccca cggactcttt   2820

cctctgaacc ctgttagggc ttggttttaa aggattttat gtgtgtttcc gaatgtttta   2880

gttagccttt tggtggagcc gccagctgac aggacatctt acaagagaat ttgcacatct   2940

ctggaagctt agcaatctta ttgcacactg ttcgctggaa gctttttgaa gagcacattc   3000

tcctcagtga gctcatgagg ttttcatttt tattcttcct tccaacgtgg tgctatctct   3060

gaaacgagcg ttagagtgcc gccttagacg gaggcaggag tttcgttaga aagcggacgc   3120

tgttctaaaa aaggtctcct gcagatctgt ctgggctgtg atgacgaata ttatgaaatg   3180

tgccttttct gaagagattg tgttagctcc aaagcttttc ctatcgcagt gtttcagttc   3240

tttattttcc cttgtggata tgctgtgtga accgtcgtgt gagtgtggta tgcctgatca   3300

cagatggatt ttgttataag catcaatgtg acacttgcag gacactacaa cgtgggacat   3360

tgtttgtttc ttccatattt ggaagataaa tttatgtgta gacttttttg taagatacgg   3420

ttaataacta aaatttattg aaatggtctt gcaatgactc gtattcagat gcttaaagaa   3480

agcattgctg ctacaaatat ttctattttt agaaagggtt tttatggacc aatgccccag   3540

ttgtcagtca gagccgttgg tgtttttcat tgtttaaaat gtcacctgta aaatgggcat   3600

tatttatgtt tttttttttg cattcctgat aattgtatgt attgtataaa gaacgtctgt   3660

acattgggtt ataacactag tatatttaaa cttacaggct tatttgtaat gtaaaccacc   3720

attttaatgt actgtaatta acatggttat aatacgtaca atccttccct catcccatca   3780

cacaactttt tttgtgtgtg ataaactgat tttggtttgc aataaaacct tgaaaaatat   3840

ttacatat                                                            3848


<210>  3345
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  3345

Met Ser Glu Arg Asn Val Leu Leu Lys Asn Val Lys His Pro Phe Leu 
1               5                   10                  15


Val Gly Leu His Phe Ser Phe Gln Thr Ala Asp Lys Leu Tyr Phe Val 
            20                  25                  30


Leu Asp Tyr Ile Asn Gly Gly Glu Leu Phe Tyr His Leu Gln Arg Glu 
        35                  40                  45


Arg Cys Phe Leu Glu Pro Arg Ala Arg Phe Tyr Ala Ala Glu Ile Ala 
    50                  55                  60


Ser Ala Leu Gly Tyr Leu His Ser Leu Asn Ile Val Tyr Arg 
65                  70                  75


<210>  3346
<211>  2441
<212>  DNA
<213>  Homo sapiens

<400>  3346
gaagatcttt tggtacactt ccttcatgtc ctcttttgta ttctccctgg atgaggatag     60

aaaaatgatt tttttaaatt gaaatttcag gttcttctag caagacacaa ggcagaagaa    120

gtgttctatg cagtcaaagt tttacagaag aaagcaatcc tgaaaaagaa agaggtatga    180

gatgtgcttg atggggctgg cattggcggt agacactcct tgaataatct tgattctgga    240

atgttggtgc caagttgaaa catgccacta aatctgaatc gtcattttcc taggagaagc    300

atattatgtc ggagcggaat gttctgttga agaatgtgaa gcaccctttc ctggtgggcc    360

ttcacttctc tttccagact gctgacaaat tgtactttgt cctagactac attaatggtg    420

gagaggtgag caggggggat agaagtcaac tcttagtgtc tctgcacagc ctgctttgtt    480

ttagtttgag aaaaaagttt tcaaagattt ttggtgggga gaatgttacc agaattagca    540

tttccttcaa cctgtcaggt ttatagttaa tagattactt ggggccactt cctgcagttg    600

ttcttttgct gtgtatgtca aaactaatta aattcatttg caacccagaa tgactttgtt    660

ctgtctcctg cagttgttct accatctcca gagggaacgc tgcttcctgg aaccacgggc    720

tcgtttctat gctgctgaaa tagccagtgc cttgggctac ctgcattcac tgaacatcgt    780

ttatagagac ttaaaaccag agaatatttt gctagattca cagggacaca ttgtccttac    840

tgacttcgga ctctgcaagg agaacattga acacaacagc acaacatcca ccttctgtgg    900

cacgccggag tatctcgcac ctgaggtgct tcataagcag ccttatgaca ggactgtgga    960

ctggtggtgc ctgggagctg tcttgtatga gatgctgtat ggcctgccgc ctttttatag   1020

ccgaaacaca gctgaaatgt acgacaacat tctgaacaag cctctccagc tgaaaccaaa   1080

tattacaaat tccgcaagac acctcctgga gggcctcctg cagaaggaca ggacaaagcg   1140

gctcggggcc aaggatgact tcatggagat taagagtcat gtcttcttct ccttaattaa   1200

ctgggatgat ctcattaata agaagattac tccccctttt aacccaaatg tgagtgggcc   1260

caacgaccta cggcactttg accccgagtt taccgaagag cctgtcccca actccattgg   1320

caagtcccct gacagcgtcc tcgtcacagc cagcgtcaag gaagctgccg aggctttcct   1380

aggcttttcc tatgcgcctc ccacggactc tttcctctga accctgttag ggcttggttt   1440

taaaggattt tatgtgtgtt tccgaatgtt ttagttagcc ttttggtgga gccgccagct   1500

gacaggacat cttacaagag aatttgcaca tctctggaag cttagcaatc ttattgcaca   1560

ctgttcgctg gaagcttttt gaagagcaca ttctcctcag tgagctcatg aggttttcat   1620

ttttattctt ccttccaacg tggtgctatc tctgaaacga gcgttagagt gccgccttag   1680

acggaggcag gagtttcgtt agaaagcgga cgctgttcta aaaaaggtct cctgcagatc   1740

tgtctgggct gtgatgacga atattatgaa atgtgccttt tctgaagaga ttgtgttagc   1800

tccaaagctt ttcctatcgc agtgtttcag ttctttattt tcccttgtgg atatgctgtg   1860

tgaaccgtcg tgtgagtgtg gtatgcctga tcacagatgg attttgttat aagcatcaat   1920

gtgacacttg caggacacta caacgtggga cattgtttgt ttcttccata tttggaagat   1980

aaatttatgt gtagactttt ttgtaagata cggttaataa ctaaaattta ttgaaatggt   2040

cttgcaatga ctcgtattca gatgcttaaa gaaagcattg ctgctacaaa tatttctatt   2100

tttagaaagg gtttttatgg accaatgccc cagttgtcag tcagagccgt tggtgttttt   2160

cattgtttaa aatgtcacct gtaaaatggg cattatttat gttttttttt ttgcattcct   2220

gataattgta tgtattgtat aaagaacgtc tgtacattgg gttataacac tagtatattt   2280

aaacttacag gcttatttgt aatgtaaacc accattttaa tgtactgtaa ttaacatggt   2340

tataatacgt acaatccttc cctcatccca tcacacaact ttttttgtgt gtgataaact   2400

gattttggtt tgcaataaaa ccttgaaaaa tatttacata t                       2441


<210>  3347
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  3347

Met Thr Leu Phe Cys Leu Leu Gln Leu Phe Tyr His Leu Gln Arg Glu 
1               5                   10                  15


Arg Cys Phe Leu Glu Pro Arg Ala Arg Phe Tyr Ala Ala Glu Ile Ala 
            20                  25                  30


Ser Ala Leu Gly Tyr Leu His Ser Leu Asn Ile Val Tyr Arg Asp Leu 
        35                  40                  45


Lys Pro Glu Asn Ile Leu Leu Asp Ser Gln Gly His Ile Val Leu Thr 
    50                  55                  60


Asp Phe Gly Leu Cys Lys Glu Asn Ile Glu His Asn Ser Thr Thr Ser 
65                  70                  75                  80


Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val Leu His Lys 
                85                  90                  95


Gln Pro Tyr Asp Arg Thr Val Asp Trp Trp Cys Leu Gly Ala Val Leu 
            100                 105                 110


Tyr Glu Met Leu Tyr Gly Leu Pro Pro Phe Tyr Ser Arg Asn Thr Ala 
        115                 120                 125


Glu Met Tyr Asp Asn Ile Leu Asn Lys Pro Leu Gln Leu Lys Pro Asn 
    130                 135                 140


Ile Thr Asn Ser Ala Arg His Leu Leu Glu Gly Leu Leu Gln Lys Asp 
145                 150                 155                 160


Arg Thr Lys Arg Leu Gly Ala Lys Asp Asp Phe Met Glu Ile Lys Ser 
                165                 170                 175


His Val Phe Phe Ser Leu Ile Asn Trp Asp Asp Leu Ile Asn Lys Lys 
            180                 185                 190


Ile Thr Pro Pro Phe Asn Pro Asn Val Ser Gly Pro Asn Asp Leu Arg 
        195                 200                 205


His Phe Asp Pro Glu Phe Thr Glu Glu Pro Val Pro Asn Ser Ile Gly 
    210                 215                 220


Lys Ser Pro Asp Ser Val Leu Val Thr Ala Ser Val Lys Glu Ala Ala 
225                 230                 235                 240


Glu Ala Phe Leu Gly Phe Ser Tyr Ala Pro Pro Thr Asp Ser Phe Leu 
                245                 250                 255


<210>  3348
<211>  4806
<212>  DNA
<213>  Homo sapiens

<400>  3348
atccacagct ttcatgaagc agaggaggat gggtctgaac gactttattc agaagattgc     60

caataactcc tatgcatgca aacagtaagt ttgaccggat ttgaggaaat aactagtata    120

gtttgaattt gccagcggta aacattctca tcacggcgtt tatcgggaag gcgaagactt    180

cttctggggt ggggatctca tttctcctta aattctaata tatttgacac attttaaaca    240

ttaaagttaa tttgctgatt tggcttgaac tggagatgta agataaatgg ttcgtgttgg    300

ccgaattcac ggcctttctc catgagcaac aatccttatt tctgtattta atggggttta    360

ttattttctt taactgacta atgtattggg gtattttcag tttaaacagt gaattatccg    420

ggtagaagtc ggtagagcca gaaactcact tttgatgttg gtgtgccccc tagtggcgag    480

ctggattcta aatcgtgccc tttattccct gcagccctga agttcagtcc atcttgaaga    540

tctcccaacc tcaggagcct gagcttatga atgccaaccc ttctcctcca ccaagtcctt    600

ctcagcaaat caaccttggc ccgtcgtcca atcctcatgc taaaccatct gactttcact    660

tcttgaaagt gatcggaaag ggcagttttg gaaaggttct tctagcaaga cacaaggcag    720

aagaagtgtt ctatgcagtc aaagttttac agaagaaagc aatcctgaaa aagaaagagg    780

tatgagatgt gcttgatggg gctggcattg gcggtagaca ctccttgaat aatcttgatt    840

ctggaatgtt ggtgccaagt tgaaacatgc cactaaatct gaatcgtcat tttcctagga    900

gaagcatatt atgtcggagc ggaatgttct gttgaagaat gtgaagcacc ctttcctggt    960

gggccttcac ttctctttcc agactgctga caaattgtac tttgtcctag actacattaa   1020

tggtggagag gtgagcaggg gggatagaag tcaactctta gtgtctctgc acagcctgct   1080

ttgttttagt ttgagaaaaa agttttcaaa gatttttggt ggggagaatg ttaccagaat   1140

tagcatttcc ttcaacctgt caggtttata gttaatagat tacttggggc cacttcctgc   1200

agttgttctt ttgctgtgta tgtcaaaact aattaaattc atttgcaacc cagaatgact   1260

ttgttctgtc tcctgcagtt gttctaccat ctccagaggg aacgctgctt cctggaacca   1320

cgggctcgtt tctatgctgc tgaaatagcc agtgccttgg gctacctgca ttcactgaac   1380

atcgtttata ggtaagcctg agagctcttc aggctaccag ttttggtata aaggagacgt   1440

agcactggct gtttcatagg gccttaaaat aatttgtgtt tatttgcaac ttggttgcct   1500

aaaaccagat cccctagcac gtgagctggc ttgacttaag tgccaagggg gaaccagcca   1560

agtaggattg tgcctaatcc agaatagatg agcagaacaa gggctccctt ttttcttcac   1620

tacacaacta cagtgaacct aaaatgcctc taataccttt agcaattatc tttaagagga   1680

tatcttatga agtgaaatta acttgtgcaa ctacttttct attcactttt ttacagagac   1740

ttaaaaccag agaatatttt gctagattca cagggacaca ttgtccttac tgacttcgga   1800

ctctgcaagg agaacattga acacaacagc acaacatcca ccttctgtgg cacgccggag   1860

gtaggcgctg tcttggtttg gtgcctggtt tacccccgcc ttccaagaga gagatgtaca   1920

atcatgcact taactaccaa aaagagtaaa ctcctctcag agacttctta atacagttca   1980

gtgcaaataa aatacatttg ctgtttgatg tagcatgaga aatcccaagt ccttctgttc   2040

ctttactgaa aagtagctgt ttgtaagtaa gatctgcatc ataaaaactt tctaaatccc   2100

taagtaagag atatcaagtg cccagcagtt tcctaaatgt cagtacacat aggtagccag   2160

tcaccctcaa aaagtccagc agttttatca ggaaggaatc taaagatatc tatcttccaa   2220

gctggctctg ggtctctcag ctttttcaaa ctaaatgtgt ggtcgtggga ttgcttgctt   2280

tcgcaggttc taaacgctgt ttccctggtc tgtttttcag tatctcgcac ctgaggtgct   2340

tcataagcag ccttatgaca ggactgtgga ctggtggtgc ctgggagctg tcttgtatga   2400

gatgctgtat ggcctggtga gtggcacatt gggaaccatg gaacactgcc tgctccctac   2460

aatattgcct tcacacagcc catgcttggc catggtgtct tgcccttacc agtacgctta   2520

tcaaaagcag ctaagaggca tattggttat tttatagttc ataagaataa tcacttacct   2580

ggttcttttg tgcatttcac attttactag ataggaccac attgaacctg tgtggtggtg   2640

aaaaactacc acttattaac atctaccccc tcaccctcca cacacacaca cacaaacaca   2700

cacacgggtt gcaaagtaga cacttaaata gcaagggaaa agaaagcatt gaggtgggga   2760

gagtttctca aatcgagcct aatatttatt gccgtttata tctttttctc tactggtaat   2820

gtgtgccata tgaaacttcc aattaagtct aaagtaattt tccccttctt tcagccgcct   2880

ttttatagcc gaaacacagc tgaaatgtac gacaacattc tgaacaagcc tctccagctg   2940

aaaccaaata ttacaaattc cgcaagacac ctcctggagg gcctcctgca gaaggacagg   3000

acaaagcggc tcggggccaa ggatgacttc gtgagtgatg ttttcctgtc ctcctgggcc   3060

ggccgggacg tgcactagac ctccctgccc ttattgaatg cacctgtcta aattaatctt   3120

gggtttctta tcaacagatg gagattaaga gtcatgtctt cttctcctta attaactggg   3180

atgatctcat taataagaag attactcccc cttttaaccc aaatgtggtg agtatctgtc   3240

tctcttctaa gtatagagaa gcccaaaggg catttatttt aattcagaat tgtctggggg   3300

agggttggaa ggaatacatt ggcagatgtt ttctccataa acctgttatt ttacctacat   3360

aaaaagcaca tttttgtgtc ccaacaaggc tcccataatt tttagacaca tttatcaatt   3420

cgaagcacca aaaggcaaca agtgaacatt attcttatgt ttaactgtgt gtagcctttt   3480

gagattttgt gcttgaagtg ggtgattatg gaagttgata taagacttaa acttggtatt   3540

taaagcctgg tcaagatttc cctgtcctgt gtctagtgtg agttcttgac aagagtgttt   3600

ttcccttccc gtcacagagt gggcccaacg acctacggca ctttgacccc gagtttaccg   3660

aagagcctgt ccccaactcc attggcaagt cccctgacag cgtcctcgtc acagccagcg   3720

tcaaggaagc tgccgaggct ttcctaggct tttcctatgc gcctcccacg gactctttcc   3780

tctgaaccct gttagggctt ggttttaaag gattttatgt gtgtttccga atgttttagt   3840

tagccttttg gtggagccgc cagctgacag gacatcttac aagagaattt gcacatctct   3900

ggaagcttag caatcttatt gcacactgtt cgctggaagc tttttgaaga gcacattctc   3960

ctcagtgagc tcatgaggtt ttcattttta ttcttccttc caacgtggtg ctatctctga   4020

aacgagcgtt agagtgccgc cttagacgga ggcaggagtt tcgttagaaa gcggacgctg   4080

ttctaaaaaa ggtctcctgc agatctgtct gggctgtgat gacgaatatt atgaaatgtg   4140

ccttttctga agagattgtg ttagctccaa agcttttcct atcgcagtgt ttcagttctt   4200

tattttccct tgtggatatg ctgtgtgaac cgtcgtgtga gtgtggtatg cctgatcaca   4260

gatggatttt gttataagca tcaatgtgac acttgcagga cactacaacg tgggacattg   4320

tttgtttctt ccatatttgg aagataaatt tatgtgtaga cttttttgta agatacggtt   4380

aataactaaa atttattgaa atggtcttgc aatgactcgt attcagatgc ttaaagaaag   4440

cattgctgct acaaatattt ctatttttag aaagggtttt tatggaccaa tgccccagtt   4500

gtcagtcaga gccgttggtg tttttcattg tttaaaatgt cacctgtaaa atgggcatta   4560

tttatgtttt tttttttgca ttcctgataa ttgtatgtat tgtataaaga acgtctgtac   4620

attgggttat aacactagta tatttaaact tacaggctta tttgtaatgt aaaccaccat   4680

tttaatgtac tgtaattaac atggttataa tacgtacaat ccttccctca tcccatcaca   4740

caactttttt tgtgtgtgat aaactgattt tggtttgcaa taaaaccttg aaaaatattt   4800

acatat                                                              4806


<210>  3349
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  3349

Met Asn Ala Asn Pro Ser Pro Pro Pro Ser Pro Ser Gln Gln Ile Asn 
1               5                   10                  15


Leu Gly Pro Ser Ser Asn Pro His Ala Lys Pro Ser Asp Phe His Phe 
            20                  25                  30


Leu Lys Val Ile Gly Lys Gly Ser Phe Gly Lys Val Leu Leu Ala Arg 
        35                  40                  45


His Lys Ala Glu Glu Val Phe Tyr Ala Val Lys Val Leu Gln Lys Lys 
    50                  55                  60


Ala Ile Leu Lys Lys Lys Glu Val 
65                  70


<210>  3350
<211>  4501
<212>  DNA
<213>  Homo sapiens

<400>  3350
agcatacgcc gagccggtct ttgagcgcta acgtctttct gtctccccgc ggtggtgatg     60

acggtgaaaa ctgaggctgc taagggcacc ctcacttact ccaggatgag gggcatggtg    120

gcaattctca tcgctttcat gaagcagagg aggatgggtc tgaacgactt tattcagaag    180

attgccaata actcctatgc atgcaaacac cctgaagttc agtccatctt gaagatctcc    240

caacctcagg agcctgagct tatgaatgcc aacccttctc ctccaccaag tccttctcag    300

caaatcaacc ttggcccgtc gtccaatcct catgctaaac catctgactt tcacttcttg    360

aaagtgatcg gaaagggcag ttttggaaag gttcttctag caagacacaa ggcagaagaa    420

gtgttctatg cagtcaaagt tttacagaag aaagcaatcc tgaaaaagaa agaggtatga    480

gatgtgcttg atggggctgg cattggcggt agacactcct tgaataatct tgattctgga    540

atgttggtgc caagttgaaa catgccacta aatctgaatc gtcattttcc taggagaagc    600

atattatgtc ggagcggaat gttctgttga agaatgtgaa gcaccctttc ctggtgggcc    660

ttcacttctc tttccagact gctgacaaat tgtactttgt cctagactac attaatggtg    720

gagaggtgag caggggggat agaagtcaac tcttagtgtc tctgcacagc ctgctttgtt    780

ttagtttgag aaaaaagttt tcaaagattt ttggtgggga gaatgttacc agaattagca    840

tttccttcaa cctgtcaggt ttatagttaa tagattactt ggggccactt cctgcagttg    900

ttcttttgct gtgtatgtca aaactaatta aattcatttg caacccagaa tgactttgtt    960

ctgtctcctg cagttgttct accatctcca gagggaacgc tgcttcctgg aaccacgggc   1020

tcgtttctat gctgctgaaa tagccagtgc cttgggctac ctgcattcac tgaacatcgt   1080

ttataggtaa gcctgagagc tcttcaggct accagttttg gtataaagga gacgtagcac   1140

tggctgtttc atagggcctt aaaataattt gtgtttattt gcaacttggt tgcctaaaac   1200

cagatcccct agcacgtgag ctggcttgac ttaagtgcca agggggaacc agccaagtag   1260

gattgtgcct aatccagaat agatgagcag aacaagggct cccttttttc ttcactacac   1320

aactacagtg aacctaaaat gcctctaata cctttagcaa ttatctttaa gaggatatct   1380

tatgaagtga aattaacttg tgcaactact tttctattca cttttttaca gagacttaaa   1440

accagagaat attttgctag attcacaggg acacattgtc cttactgact tcggactctg   1500

caaggagaac attgaacaca acagcacaac atccaccttc tgtggcacgc cggaggtagg   1560

cgctgtcttg gtttggtgcc tggtttaccc ccgccttcca agagagagat gtacaatcat   1620

gcacttaact accaaaaaga gtaaactcct ctcagagact tcttaataca gttcagtgca   1680

aataaaatac atttgctgtt tgatgtagca tgagaaatcc caagtccttc tgttccttta   1740

ctgaaaagta gctgtttgta agtaagatct gcatcataaa aactttctaa atccctaagt   1800

aagagatatc aagtgcccag cagtttccta aatgtcagta cacataggta gccagtcacc   1860

ctcaaaaagt ccagcagttt tatcaggaag gaatctaaag atatctatct tccaagctgg   1920

ctctgggtct ctcagctttt tcaaactaaa tgtgtggtcg tgggattgct tgctttcgca   1980

ggttctaaac gctgtttccc tggtctgttt ttcagtatct cgcacctgag gtgcttcata   2040

agcagcctta tgacaggact gtggactggt ggtgcctggg agctgtcttg tatgagatgc   2100

tgtatggcct ggtgagtggc acattgggaa ccatggaaca ctgcctgctc cctacaatat   2160

tgccttcaca cagcccatgc ttggccatgg tgtcttgccc ttaccagtac gcttatcaaa   2220

agcagctaag aggcatattg gttattttat agttcataag aataatcact tacctggttc   2280

ttttgtgcat ttcacatttt actagatagg accacattga acctgtgtgg tggtgaaaaa   2340

ctaccactta ttaacatcta ccccctcacc ctccacacac acacacacaa acacacacac   2400

gggttgcaaa gtagacactt aaatagcaag ggaaaagaaa gcattgaggt ggggagagtt   2460

tctcaaatcg agcctaatat ttattgccgt ttatatcttt ttctctactg gtaatgtgtg   2520

ccatatgaaa cttccaatta agtctaaagt aattttcccc ttctttcagc cgccttttta   2580

tagccgaaac acagctgaaa tgtacgacaa cattctgaac aagcctctcc agctgaaacc   2640

aaatattaca aattccgcaa gacacctcct ggagggcctc ctgcagaagg acaggacaaa   2700

gcggctcggg gccaaggatg acttcgtgag tgatgttttc ctgtcctcct gggccggccg   2760

ggacgtgcac tagacctccc tgcccttatt gaatgcacct gtctaaatta atcttgggtt   2820

tcttatcaac agatggagat taagagtcat gtcttcttct ccttaattaa ctgggatgat   2880

ctcattaata agaagattac tccccctttt aacccaaatg tggtgagtat ctgtctctct   2940

tctaagtata gagaagccca aagggcattt attttaattc agaattgtct gggggagggt   3000

tggaaggaat acattggcag atgttttctc cataaacctg ttattttacc tacataaaaa   3060

gcacattttt gtgtcccaac aaggctccca taatttttag acacatttat caattcgaag   3120

caccaaaagg caacaagtga acattattct tatgtttaac tgtgtgtagc cttttgagat   3180

tttgtgcttg aagtgggtga ttatggaagt tgatataaga cttaaacttg gtatttaaag   3240

cctggtcaag atttccctgt cctgtgtcta gtgtgagttc ttgacaagag tgtttttccc   3300

ttcccgtcac agagtgggcc caacgaccta cggcactttg accccgagtt taccgaagag   3360

cctgtcccca actccattgg caagtcccct gacagcgtcc tcgtcacagc cagcgtcaag   3420

gaagctgccg aggctttcct aggcttttcc tatgcgcctc ccacggactc tttcctctga   3480

accctgttag ggcttggttt taaaggattt tatgtgtgtt tccgaatgtt ttagttagcc   3540

ttttggtgga gccgccagct gacaggacat cttacaagag aatttgcaca tctctggaag   3600

cttagcaatc ttattgcaca ctgttcgctg gaagcttttt gaagagcaca ttctcctcag   3660

tgagctcatg aggttttcat ttttattctt ccttccaacg tggtgctatc tctgaaacga   3720

gcgttagagt gccgccttag acggaggcag gagtttcgtt agaaagcgga cgctgttcta   3780

aaaaaggtct cctgcagatc tgtctgggct gtgatgacga atattatgaa atgtgccttt   3840

tctgaagaga ttgtgttagc tccaaagctt ttcctatcgc agtgtttcag ttctttattt   3900

tcccttgtgg atatgctgtg tgaaccgtcg tgtgagtgtg gtatgcctga tcacagatgg   3960

attttgttat aagcatcaat gtgacacttg caggacacta caacgtggga cattgtttgt   4020

ttcttccata tttggaagat aaatttatgt gtagactttt ttgtaagata cggttaataa   4080

ctaaaattta ttgaaatggt cttgcaatga ctcgtattca gatgcttaaa gaaagcattg   4140

ctgctacaaa tatttctatt tttagaaagg gtttttatgg accaatgccc cagttgtcag   4200

tcagagccgt tggtgttttt cattgtttaa aatgtcacct gtaaaatggg cattatttat   4260

gttttttttt ttgcattcct gataattgta tgtattgtat aaagaacgtc tgtacattgg   4320

gttataacac tagtatattt aaacttacag gcttatttgt aatgtaaacc accattttaa   4380

tgtactgtaa ttaacatggt tataatacgt acaatccttc cctcatccca tcacacaact   4440

ttttttgtgt gtgataaact gattttggtt tgcaataaaa ccttgaaaaa tatttacata   4500

t                                                                   4501


<210>  3351
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  3351

Met Thr Val Lys Thr Glu Ala Ala Lys Gly Thr Leu Thr Tyr Ser Arg 
1               5                   10                  15


Met Arg Gly Met Val Ala Ile Leu Ile Ala Phe Met Lys Gln Arg Arg 
            20                  25                  30


Met Gly Leu Asn Asp Phe Ile Gln Lys Ile Ala Asn Asn Ser Tyr Ala 
        35                  40                  45


Cys Lys His Pro Glu Val Gln Ser Ile Leu Lys Ile Ser Gln Pro Gln 
    50                  55                  60


Glu Pro Glu Leu Met Asn Ala Asn Pro Ser Pro Pro Pro Ser Pro Ser 
65                  70                  75                  80


Gln Gln Ile Asn Leu Gly Pro Ser Ser Asn Pro His Ala Lys Pro Ser 
                85                  90                  95


Asp Phe His Phe Leu Lys Val Ile Gly Lys Gly Ser Phe Gly Lys Val 
            100                 105                 110


Leu Leu Ala Arg His Lys Ala Glu Glu Val Phe Tyr Ala Val Lys Val 
        115                 120                 125


Leu Gln Lys Lys Ala Ile Leu Lys Lys Lys Glu Val 
    130                 135                 140


<210>  3352
<211>  2483
<212>  DNA
<213>  Homo sapiens

<400>  3352
gcagcatacg ccgagccggt ctttgagcgc taacgtcttt ctgtctcccc gcggtggtga     60

tgacggtgaa aactgaggct gctaagggca ccctcactta ctccaggatg aggggcatgg    120

tggcaattct catcgctttc atgaagcaga ggaggatggg tctgaacgac tttattcaga    180

agattgccaa taactcctat gcatgcaaac accctgaagt tcagtccatc ttgaagatct    240

cccaacctca ggagcctgag cttatgaatg ccaacccttc tcctccacca agtccttctc    300

agcaaatcaa ccttggcccg tcgtccaatc ctcatgctaa accatctgac tttcacttct    360

tgaaagtgat cggaaagggc agttttggaa aggttcttct agcaagacac aaggcagaag    420

aagtgttcta tgcagtcaaa gttttacaga agaaagcaat cctgaaaaag aaagaggaga    480

agcatattat gtcggagcgg aatgttctgt tgaagaatgt gaagcaccct ttcctggtgg    540

gccttcactt ctctttccag actgctgaca aattgtactt tgtcctagac tacattaatg    600

gtggagagtt gttctaccat ctccagaggg aacgctgctt cctggaacca cgggctcgtt    660

tctatgctgc tgaaatagcc agtgccttgg gctacctgca ttcactgaac atcgtttata    720

gagacttaaa accagagaat attttgctag attcacaggg acacattgtc cttactgact    780

tcggactctg caaggagaac attgaacaca acagcacaac atccaccttc tgtggcacgc    840

cggagtatct cgcacctgag gtgcttcata agcagcctta tgacaggact gtggactggt    900

ggtgcctggg agctgtcttg tatgagatgc tgtatggcct gccgcctttt tatagccgaa    960

acacagctga aatgtacgac aacattctga acaagcctct ccagctgaaa ccaaatatta   1020

caaattccgc aagacacctc ctggagggcc tcctgcagaa ggacaggaca aagcggctcg   1080

gggccaagga tgacttcgtg agtgatgttt tcctgtcctc ctgggccggc cgggacgtgc   1140

actagacctc cctgccctta ttgaatgcac ctgtctaaat taatcttggg tttcttatca   1200

acagatggag attaagagtc atgtcttctt ctccttaatt aactgggatg atctcattaa   1260

taagaagatt actccccctt ttaacccaaa tgtgagtggg cccaacgacc tacggcactt   1320

tgaccccgag tttaccgaag agcctgtccc caactccatt ggcaagtccc ctgacagcgt   1380

cctcgtcaca gccagcgtca aggaagctgc cgaggctttc ctaggctttt cctatgcgcc   1440

tcccacggac tctttcctct gaaccctgtt agggcttggt tttaaaggat tttatgtgtg   1500

tttccgaatg ttttagttag ccttttggtg gagccgccag ctgacaggac atcttacaag   1560

agaatttgca catctctgga agcttagcaa tcttattgca cactgttcgc tggaagcttt   1620

ttgaagagca cattctcctc agtgagctca tgaggttttc atttttattc ttccttccaa   1680

cgtggtgcta tctctgaaac gagcgttaga gtgccgcctt agacggaggc aggagtttcg   1740

ttagaaagcg gacgctgttc taaaaaaggt ctcctgcaga tctgtctggg ctgtgatgac   1800

gaatattatg aaatgtgcct tttctgaaga gattgtgtta gctccaaagc ttttcctatc   1860

gcagtgtttc agttctttat tttcccttgt ggatatgctg tgtgaaccgt cgtgtgagtg   1920

tggtatgcct gatcacagat ggattttgtt ataagcatca atgtgacact tgcaggacac   1980

tacaacgtgg gacattgttt gtttcttcca tatttggaag ataaatttat gtgtagactt   2040

ttttgtaaga tacggttaat aactaaaatt tattgaaatg gtcttgcaat gactcgtatt   2100

cagatgctta aagaaagcat tgctgctaca aatatttcta tttttagaaa gggtttttat   2160

ggaccaatgc cccagttgtc agtcagagcc gttggtgttt ttcattgttt aaaatgtcac   2220

ctgtaaaatg ggcattattt atgttttttt ttttgcattc ctgataattg tatgtattgt   2280

ataaagaacg tctgtacatt gggttataac actagtatat ttaaacttac aggcttattt   2340

gtaatgtaaa ccaccatttt aatgtactgt aattaacatg gttataatac gtacaatcct   2400

tccctcatcc catcacacaa ctttttttgt gtgtgataaa ctgattttgg tttgcaataa   2460

aaccttgaaa aatatttaca tat                                           2483


<210>  3353
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  3353

Met Thr Val Lys Thr Glu Ala Ala Lys Gly Thr Leu Thr Tyr Ser Arg 
1               5                   10                  15


Met Arg Gly Met Val Ala Ile Leu Ile Ala Phe Met Lys Gln Arg Arg 
            20                  25                  30


Met Gly Leu Asn Asp Phe Ile Gln Lys Ile Ala Asn Asn Ser Tyr Ala 
        35                  40                  45


Cys Lys His Pro Glu Val Gln Ser Ile Leu Lys Ile Ser Gln Pro Gln 
    50                  55                  60


Glu Pro Glu Leu Met Asn Ala Asn Pro Ser Pro Pro Pro Ser Pro Ser 
65                  70                  75                  80


Gln Gln Ile Asn Leu Gly Pro Ser Ser Asn Pro His Ala Lys Pro Ser 
                85                  90                  95


Asp Phe His Phe Leu Lys Val Ile Gly Lys Gly Ser Phe Gly Lys Val 
            100                 105                 110


Leu Leu Ala Arg His Lys Ala Glu Glu Val Phe Tyr Ala Val Lys Val 
        115                 120                 125


Leu Gln Lys Lys Ala Ile Leu Lys Lys Lys Glu Glu Lys His Ile Met 
    130                 135                 140


Ser Glu Arg Asn Val Leu Leu Lys Asn Val Lys His Pro Phe Leu Val 
145                 150                 155                 160


Gly Leu His Phe Ser Phe Gln Thr Ala Asp Lys Leu Tyr Phe Val Leu 
                165                 170                 175


Asp Tyr Ile Asn Gly Gly Glu Leu Phe Tyr His Leu Gln Arg Glu Arg 
            180                 185                 190


Cys Phe Leu Glu Pro Arg Ala Arg Phe Tyr Ala Ala Glu Ile Ala Ser 
        195                 200                 205


Ala Leu Gly Tyr Leu His Ser Leu Asn Ile Val Tyr Arg Asp Leu Lys 
    210                 215                 220


Pro Glu Asn Ile Leu Leu Asp Ser Gln Gly His Ile Val Leu Thr Asp 
225                 230                 235                 240


Phe Gly Leu Cys Lys Glu Asn Ile Glu His Asn Ser Thr Thr Ser Thr 
                245                 250                 255


Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val Leu His Lys Gln 
            260                 265                 270


Pro Tyr Asp Arg Thr Val Asp Trp Trp Cys Leu Gly Ala Val Leu Tyr 
        275                 280                 285


Glu Met Leu Tyr Gly Leu Pro Pro Phe Tyr Ser Arg Asn Thr Ala Glu 
    290                 295                 300


Met Tyr Asp Asn Ile Leu Asn Lys Pro Leu Gln Leu Lys Pro Asn Ile 
305                 310                 315                 320


Thr Asn Ser Ala Arg His Leu Leu Glu Gly Leu Leu Gln Lys Asp Arg 
                325                 330                 335


Thr Lys Arg Leu Gly Ala Lys Asp Asp Phe Val Ser Asp Val Phe Leu 
            340                 345                 350


Ser Ser Trp Ala Gly Arg Asp Val His 
        355                 360


<210>  3354
<211>  5475
<212>  DNA
<213>  Homo sapiens

<400>  3354
gcagcatacg ccgagccggt ctttgagcgc taacgtcttt ctgtctcccc gcggtggtga     60

tgacggtgaa aactgaggct gctaagggca ccctcactta ctccaggatg aggggcatgg    120

tggcaattct catcgctttc atgaagcaga ggaggatggg tctgaacgac tttattcaga    180

agattgccaa taactcctat gcatgcaaac agtaagtttg accggatttg aggaaataac    240

tagtatagtt tgaatttgcc agcggtaaac attctcatca cggcgtttat cgggaaggcg    300

aagacttctt ctggggtggg gatctcattt ctccttaaat tctaatatat ttgacacatt    360

ttaaacatta aagttaattt gctgatttgg cttgaactgg agatgtaaga taaatggttc    420

gtgttggccg aattcacggc ctttctccat gagcaacaat ccttatttct gtatttaatg    480

gggtttatta ttttctttaa ctgactaatg tattggggta ttttcagttt aaacagtgaa    540

ttatccgggt agaagtcggt agagccagaa actcactttt gatgttggtg tgccccctag    600

tggcgagctg gattctaaat cgtgcccttt attccctgca gccctgaagt tcagtccatc    660

ttgaagatct cccaacctca ggagcctgag cttatgaatg ccaacccttc tcctccagta    720

agtttttgta tgtgccgtgc atctgtggag aactgtaagg gagtcagtta gtattcctac    780

attaatggat taaaatagca tttctagaaa ttagtatcaa ggcaggaatg cttcattatg    840

gcataacaag tgatataaat atttaagtat tgagtcagag tattatttta tttttttcct    900

gggcatattt tacctccaaa gtggttattt taaaaggcat atttcataaa aaggttttat    960

ctgtctgaaa caacatgact gtgtgcagtt tccatactca tttgaaatgt gatgaaatgt   1020

agttttgaat gtttatagat gtatggtcat ttgcatcagt catttgtaga tgtaacattt   1080

tctacatcgt ttatgttata gatgtcttcc tttgaagcaa tggtattaaa agaaattctt   1140

tttttttttt tctagccaag tccttctcag caaatcaacc ttggcccgtc gtccaatcct   1200

catgctaaac catctgactt tcacttcttg aaagtgatcg gaaagggcag ttttggaaag   1260

gtaatttcaa atctgaagat cttttggtac acttccttca tgtcctcttt tgtattctcc   1320

ctggatgagg atagaaaaat gattttttta aattgaaatt tcaggttctt ctagcaagac   1380

acaaggcaga agaagtgttc tatgcagtca aagttttaca gaagaaagca atcctgaaaa   1440

agaaagaggt atgagatgtg cttgatgggg ctggcattgg cggtagacac tccttgaata   1500

atcttgattc tggaatgttg gtgccaagtt gaaacatgcc actaaatctg aatcgtcatt   1560

ttcctaggag aagcatatta tgtcggagcg gaatgttctg ttgaagaatg tgaagcaccc   1620

tttcctggtg ggccttcact tctctttcca gactgctgac aaattgtact ttgtcctaga   1680

ctacattaat ggtggagagg tgagcagggg ggatagaagt caactcttag tgtctctgca   1740

cagcctgctt tgttttagtt tgagaaaaaa gttttcaaag atttttggtg gggagaatgt   1800

taccagaatt agcatttcct tcaacctgtc aggtttatag ttaatagatt acttggggcc   1860

acttcctgca gttgttcttt tgctgtgtat gtcaaaacta attaaattca tttgcaaccc   1920

agaatgactt tgttctgtct cctgcagttg ttctaccatc tccagaggga acgctgcttc   1980

ctggaaccac gggctcgttt ctatgctgct gaaatagcca gtgccttggg ctacctgcat   2040

tcactgaaca tcgtttatag gtaagcctga gagctcttca ggctaccagt tttggtataa   2100

aggagacgta gcactggctg tttcataggg ccttaaaata atttgtgttt atttgcaact   2160

tggttgccta aaaccagatc ccctagcacg tgagctggct tgacttaagt gccaaggggg   2220

aaccagccaa gtaggattgt gcctaatcca gaatagatga gcagaacaag ggctcccttt   2280

tttcttcact acacaactac agtgaaccta aaatgcctct aataccttta gcaattatct   2340

ttaagaggat atcttatgaa gtgaaattaa cttgtgcaac tacttttcta ttcacttttt   2400

tacagagact taaaaccaga gaatattttg ctagattcac agggacacat tgtccttact   2460

gacttcggac tctgcaagga gaacattgaa cacaacagca caacatccac cttctgtggc   2520

acgccggagg taggcgctgt cttggtttgg tgcctggttt acccccgcct tccaagagag   2580

agatgtacaa tcatgcactt aactaccaaa aagagtaaac tcctctcaga gacttcttaa   2640

tacagttcag tgcaaataaa atacatttgc tgtttgatgt agcatgagaa atcccaagtc   2700

cttctgttcc tttactgaaa agtagctgtt tgtaagtaag atctgcatca taaaaacttt   2760

ctaaatccct aagtaagaga tatcaagtgc ccagcagttt cctaaatgtc agtacacata   2820

ggtagccagt caccctcaaa aagtccagca gttttatcag gaaggaatct aaagatatct   2880

atcttccaag ctggctctgg gtctctcagc tttttcaaac taaatgtgtg gtcgtgggat   2940

tgcttgcttt cgcaggttct aaacgctgtt tccctggtct gtttttcagt atctcgcacc   3000

tgaggtgctt cataagcagc cttatgacag gactgtggac tggtggtgcc tgggagctgt   3060

cttgtatgag atgctgtatg gcctggtgag tggcacattg ggaaccatgg aacactgcct   3120

gctccctaca atattgcctt cacacagccc atgcttggcc atggtgtctt gcccttacca   3180

gtacgcttat caaaagcagc taagaggcat attggttatt ttatagttca taagaataat   3240

cacttacctg gttcttttgt gcatttcaca ttttactaga taggaccaca ttgaacctgt   3300

gtggtggtga aaaactacca cttattaaca tctaccccct caccctccac acacacacac   3360

acaaacacac acacgggttg caaagtagac acttaaatag caagggaaaa gaaagcattg   3420

aggtggggag agtttctcaa atcgagccta atatttattg ccgtttatat ctttttctct   3480

actggtaatg tgtgccatat gaaacttcca attaagtcta aagtaatttt ccccttcttt   3540

cagccgcctt tttatagccg aaacacagct gaaatgtacg acaacattct gaacaagcct   3600

ctccagctga aaccaaatat tacaaattcc gcaagacacc tcctggaggg cctcctgcag   3660

aaggacagga caaagcggct cggggccaag gatgacttcg tgagtgatgt tttcctgtcc   3720

tcctgggccg gccgggacgt gcactagacc tccctgccct tattgaatgc acctgtctaa   3780

attaatcttg ggtttcttat caacagatgg agattaagag tcatgtcttc ttctccttaa   3840

ttaactggga tgatctcatt aataagaaga ttactccccc ttttaaccca aatgtggtga   3900

gtatctgtct ctcttctaag tatagagaag cccaaagggc atttatttta attcagaatt   3960

gtctggggga gggttggaag gaatacattg gcagatgttt tctccataaa cctgttattt   4020

tacctacata aaaagcacat ttttgtgtcc caacaaggct cccataattt ttagacacat   4080

ttatcaattc gaagcaccaa aaggcaacaa gtgaacatta ttcttatgtt taactgtgtg   4140

tagccttttg agattttgtg cttgaagtgg gtgattatgg aagttgatat aagacttaaa   4200

cttggtattt aaagcctggt caagatttcc ctgtcctgtg tctagtgtga gttcttgaca   4260

agagtgtttt tcccttcccg tcacagagtg ggcccaacga cctacggcac tttgaccccg   4320

agtttaccga agagcctgtc cccaactcca ttggcaagtc ccctgacagc gtcctcgtca   4380

cagccagcgt caaggaagct gccgaggctt tcctaggctt ttcctatgcg cctcccacgg   4440

actctttcct ctgaaccctg ttagggcttg gttttaaagg attttatgtg tgtttccgaa   4500

tgttttagtt agccttttgg tggagccgcc agctgacagg acatcttaca agagaatttg   4560

cacatctctg gaagcttagc aatcttattg cacactgttc gctggaagct ttttgaagag   4620

cacattctcc tcagtgagct catgaggttt tcatttttat tcttccttcc aacgtggtgc   4680

tatctctgaa acgagcgtta gagtgccgcc ttagacggag gcaggagttt cgttagaaag   4740

cggacgctgt tctaaaaaag gtctcctgca gatctgtctg ggctgtgatg acgaatatta   4800

tgaaatgtgc cttttctgaa gagattgtgt tagctccaaa gcttttccta tcgcagtgtt   4860

tcagttcttt attttccctt gtggatatgc tgtgtgaacc gtcgtgtgag tgtggtatgc   4920

ctgatcacag atggattttg ttataagcat caatgtgaca cttgcaggac actacaacgt   4980

gggacattgt ttgtttcttc catatttgga agataaattt atgtgtagac ttttttgtaa   5040

gatacggtta ataactaaaa tttattgaaa tggtcttgca atgactcgta ttcagatgct   5100

taaagaaagc attgctgcta caaatatttc tatttttaga aagggttttt atggaccaat   5160

gccccagttg tcagtcagag ccgttggtgt ttttcattgt ttaaaatgtc acctgtaaaa   5220

tgggcattat ttatgttttt ttttttgcat tcctgataat tgtatgtatt gtataaagaa   5280

cgtctgtaca ttgggttata acactagtat atttaaactt acaggcttat ttgtaatgta   5340

aaccaccatt ttaatgtact gtaattaaca tggttataat acgtacaatc cttccctcat   5400

cccatcacac aacttttttt gtgtgtgata aactgatttt ggtttgcaat aaaaccttga   5460

aaaatattta catat                                                    5475


<210>  3355
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  3355

Met Thr Val Lys Thr Glu Ala Ala Lys Gly Thr Leu Thr Tyr Ser Arg 
1               5                   10                  15


Met Arg Gly Met Val Ala Ile Leu Ile Ala Phe Met Lys Gln Arg Arg 
            20                  25                  30


Met Gly Leu Asn Asp Phe Ile Gln Lys Ile Ala Asn Asn Ser Tyr Ala 
        35                  40                  45


Cys Lys Gln 
    50


<210>  3356
<211>  2376
<212>  DNA
<213>  Homo sapiens

<400>  3356
gcagcatacg ccgagccggt ctttgagcgc taacgtcttt ctgtctcccc gcggtggtga     60

tgacggtgaa aactgaggct gctaagggca ccctcactta ctccaggatg aggggcatgg    120

tggcaattct catcgctttc atgaagcaga ggaggatggg tctgaacgac tttattcaga    180

agattgccaa taactcctat gcatgcaaac accctgaagt tcagtccatc ttgaagatct    240

cccaacctca ggagcctgag cttatgaatg ccaacccttc tcctccacca agtccttctc    300

agcaaatcaa ccttggcccg tcgtccaatc ctcatgctaa accatctgac tttcacttct    360

tgaaagtgat cggaaagggc agttttggaa aggttcttct agcaagacac aaggcagaag    420

aagtgttcta tgcagtcaaa gttttacaga agaaagcaat cctgaaaaag aaagaggaga    480

agcatattat gtcggagcgg aatgttctgt tgaagaatgt gaagcaccct ttcctggtgg    540

gccttcactt ctctttccag actgctgaca aattgtactt tgtcctagac tacattaatg    600

gtggagagtt gttctaccat ctccagaggg aacgctgctt cctggaacca cgggctcgtt    660

tctatgctgc tgaaatagcc agtgccttgg gctacctgca ttcactgaac atcgtttata    720

gagacttaaa accagagaat attttgctag attcacaggg acacattgtc cttactgact    780

tcggactctg caaggagaac attgaacaca acagcacaac atccaccttc tgtggcacgc    840

cggagtatct cgcacctgag gtgcttcata agcagcctta tgacaggact gtggactggt    900

ggtgcctggg agctgtcttg tatgagatgc tgtatggcct gccgcctttt tatagccgaa    960

acacagctga aatgtacgac aacattctga acaagcctct ccagctgaaa ccaaatatta   1020

caaattccgc aagacacctc ctggagggcc tcctgcagaa ggacaggaca aagcggctcg   1080

gggccaagga tgacttcatg gagattaaga gtcatgtctt cttctcctta attaactggg   1140

atgatctcat taataagaag attactcccc cttttaaccc aaatgtgagt gggcccaacg   1200

acctacggca ctttgacccc gagtttaccg aagagcctgt ccccaactcc attggcaagt   1260

cccctgacag cgtcctcgtc acagccagcg tcaaggaagc tgccgaggct ttcctaggct   1320

tttcctatgc gcctcccacg gactctttcc tctgaaccct gttagggctt ggttttaaag   1380

gattttatgt gtgtttccga atgttttagt tagccttttg gtggagccgc cagctgacag   1440

gacatcttac aagagaattt gcacatctct ggaagcttag caatcttatt gcacactgtt   1500

cgctggaagc tttttgaaga gcacattctc ctcagtgagc tcatgaggtt ttcattttta   1560

ttcttccttc caacgtggtg ctatctctga aacgagcgtt agagtgccgc cttagacgga   1620

ggcaggagtt tcgttagaaa gcggacgctg ttctaaaaaa ggtctcctgc agatctgtct   1680

gggctgtgat gacgaatatt atgaaatgtg ccttttctga agagattgtg ttagctccaa   1740

agcttttcct atcgcagtgt ttcagttctt tattttccct tgtggatatg ctgtgtgaac   1800

cgtcgtgtga gtgtggtatg cctgatcaca gatggatttt gttataagca tcaatgtgac   1860

acttgcagga cactacaacg tgggacattg tttgtttctt ccatatttgg aagataaatt   1920

tatgtgtaga cttttttgta agatacggtt aataactaaa atttattgaa atggtcttgc   1980

aatgactcgt attcagatgc ttaaagaaag cattgctgct acaaatattt ctatttttag   2040

aaagggtttt tatggaccaa tgccccagtt gtcagtcaga gccgttggtg tttttcattg   2100

tttaaaatgt cacctgtaaa atgggcatta tttatgtttt tttttttgca ttcctgataa   2160

ttgtatgtat tgtataaaga acgtctgtac attgggttat aacactagta tatttaaact   2220

tacaggctta tttgtaatgt aaaccaccat tttaatgtac tgtaattaac atggttataa   2280

tacgtacaat ccttccctca tcccatcaca caactttttt tgtgtgtgat aaactgattt   2340

tggtttgcaa taaaaccttg aaaaatattt acatat                             2376


<210>  3357
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  3357

Met Thr Val Lys Thr Glu Ala Ala Lys Gly Thr Leu Thr Tyr Ser Arg 
1               5                   10                  15


Met Arg Gly Met Val Ala Ile Leu Ile Ala Phe Met Lys Gln Arg Arg 
            20                  25                  30


Met Gly Leu Asn Asp Phe Ile Gln Lys Ile Ala Asn Asn Ser Tyr Ala 
        35                  40                  45


Cys Lys His Pro Glu Val Gln Ser Ile Leu Lys Ile Ser Gln Pro Gln 
    50                  55                  60


Glu Pro Glu Leu Met Asn Ala Asn Pro Ser Pro Pro Pro Ser Pro Ser 
65                  70                  75                  80


Gln Gln Ile Asn Leu Gly Pro Ser Ser Asn Pro His Ala Lys Pro Ser 
                85                  90                  95


Asp Phe His Phe Leu Lys Val Ile Gly Lys Gly Ser Phe Gly Lys Val 
            100                 105                 110


Leu Leu Ala Arg His Lys Ala Glu Glu Val Phe Tyr Ala Val Lys Val 
        115                 120                 125


Leu Gln Lys Lys Ala Ile Leu Lys Lys Lys Glu Glu Lys His Ile Met 
    130                 135                 140


Ser Glu Arg Asn Val Leu Leu Lys Asn Val Lys His Pro Phe Leu Val 
145                 150                 155                 160


Gly Leu His Phe Ser Phe Gln Thr Ala Asp Lys Leu Tyr Phe Val Leu 
                165                 170                 175


Asp Tyr Ile Asn Gly Gly Glu Leu Phe Tyr His Leu Gln Arg Glu Arg 
            180                 185                 190


Cys Phe Leu Glu Pro Arg Ala Arg Phe Tyr Ala Ala Glu Ile Ala Ser 
        195                 200                 205


Ala Leu Gly Tyr Leu His Ser Leu Asn Ile Val Tyr Arg Asp Leu Lys 
    210                 215                 220


Pro Glu Asn Ile Leu Leu Asp Ser Gln Gly His Ile Val Leu Thr Asp 
225                 230                 235                 240


Phe Gly Leu Cys Lys Glu Asn Ile Glu His Asn Ser Thr Thr Ser Thr 
                245                 250                 255


Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val Leu His Lys Gln 
            260                 265                 270


Pro Tyr Asp Arg Thr Val Asp Trp Trp Cys Leu Gly Ala Val Leu Tyr 
        275                 280                 285


Glu Met Leu Tyr Gly Leu Pro Pro Phe Tyr Ser Arg Asn Thr Ala Glu 
    290                 295                 300


Met Tyr Asp Asn Ile Leu Asn Lys Pro Leu Gln Leu Lys Pro Asn Ile 
305                 310                 315                 320


Thr Asn Ser Ala Arg His Leu Leu Glu Gly Leu Leu Gln Lys Asp Arg 
                325                 330                 335


Thr Lys Arg Leu Gly Ala Lys Asp Asp Phe Met Glu Ile Lys Ser His 
            340                 345                 350


Val Phe Phe Ser Leu Ile Asn Trp Asp Asp Leu Ile Asn Lys Lys Ile 
        355                 360                 365


Thr Pro Pro Phe Asn Pro Asn Val Ser Gly Pro Asn Asp Leu Arg His 
    370                 375                 380


Phe Asp Pro Glu Phe Thr Glu Glu Pro Val Pro Asn Ser Ile Gly Lys 
385                 390                 395                 400


Ser Pro Asp Ser Val Leu Val Thr Ala Ser Val Lys Glu Ala Ala Glu 
                405                 410                 415


Ala Phe Leu Gly Phe Ser Tyr Ala Pro Pro Thr Asp Ser Phe Leu 
            420                 425                 430


<210>  3358
<211>  1615
<212>  DNA
<213>  Homo sapiens

<400>  3358
ggatagccgt ctctggctcg tgctctcatg tcatctcaga gttccagctt atcagaggca     60

tgtagcaggg aggcttattc cagccataac tgggctctac ctccagcctc cagaagtaat    120

ccccaacctg catatccttg ggcaacccga agaatgaaag aagaagctat aaaaccccct    180

ttgaaagctt tcatgaagca gaggaggatg ggtctgaacg acattctgaa caagcctctc    240

cagctgaaac caaatattac aaattccgca agacacctcc tggagggcct cctgcagaag    300

gacaggacaa agcggctcgg ggccaaggat gacttcatgg agattaagag tcatgtcttc    360

ttctccttaa ttaactggga tgatctcatt aataagaaga ttactccccc ttttaaccca    420

aatgtgagtg ggcccaacga cctacggcac tttgaccccg agtttaccga agagcctgtc    480

cccaactcca ttggcaagtc ccctgacagc gtcctcgtca cagccagcgt caaggaagct    540

gccgaggctt tcctaggctt ttcctatgcg cctcccacgg actctttcct ctgaaccctg    600

ttagggcttg gttttaaagg attttatgtg tgtttccgaa tgttttagtt agccttttgg    660

tggagccgcc agctgacagg acatcttaca agagaatttg cacatctctg gaagcttagc    720

aatcttattg cacactgttc gctggaagct ttttgaagag cacattctcc tcagtgagct    780

catgaggttt tcatttttat tcttccttcc aacgtggtgc tatctctgaa acgagcgtta    840

gagtgccgcc ttagacggag gcaggagttt cgttagaaag cggacgctgt tctaaaaaag    900

gtctcctgca gatctgtctg ggctgtgatg acgaatatta tgaaatgtgc cttttctgaa    960

gagattgtgt tagctccaaa gcttttccta tcgcagtgtt tcagttcttt attttccctt   1020

gtggatatgc tgtgtgaacc gtcgtgtgag tgtggtatgc ctgatcacag atggattttg   1080

ttataagcat caatgtgaca cttgcaggac actacaacgt gggacattgt ttgtttcttc   1140

catatttgga agataaattt atgtgtagac ttttttgtaa gatacggtta ataactaaaa   1200

tttattgaaa tggtcttgca atgactcgta ttcagatgct taaagaaagc attgctgcta   1260

caaatatttc tatttttaga aagggttttt atggaccaat gccccagttg tcagtcagag   1320

ccgttggtgt ttttcattgt ttaaaatgtc acctgtaaaa tgggcattat ttatgttttt   1380

ttttttgcat tcctgataat tgtatgtatt gtataaagaa cgtctgtaca ttgggttata   1440

acactagtat atttaaactt acaggcttat ttgtaatgta aaccaccatt ttaatgtact   1500

gtaattaaca tggttataat acgtacaatc cttccctcat cccatcacac aacttttttt   1560

gtgtgtgata aactgatttt ggtttgcaat aaaaccttga aaaatattta catat        1615


<210>  3359
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  3359

Met Ser Ser Gln Ser Ser Ser Leu Ser Glu Ala Cys Ser Arg Glu Ala 
1               5                   10                  15


Tyr Ser Ser His Asn Trp Ala Leu Pro Pro Ala Ser Arg Ser Asn Pro 
            20                  25                  30


Gln Pro Ala Tyr Pro Trp Ala Thr Arg Arg Met Lys Glu Glu Ala Ile 
        35                  40                  45


Lys Pro Pro Leu Lys Ala Phe Met Lys Gln Arg Arg Met Gly Leu Asn 
    50                  55                  60


Asp Ile Leu Asn Lys Pro Leu Gln Leu Lys Pro Asn Ile Thr Asn Ser 
65                  70                  75                  80


Ala Arg His Leu Leu Glu Gly Leu Leu Gln Lys Asp Arg Thr Lys Arg 
                85                  90                  95


Leu Gly Ala Lys Asp Asp Phe Met Glu Ile Lys Ser His Val Phe Phe 
            100                 105                 110


Ser Leu Ile Asn Trp Asp Asp Leu Ile Asn Lys Lys Ile Thr Pro Pro 
        115                 120                 125


Phe Asn Pro Asn Val Ser Gly Pro Asn Asp Leu Arg His Phe Asp Pro 
    130                 135                 140


Glu Phe Thr Glu Glu Pro Val Pro Asn Ser Ile Gly Lys Ser Pro Asp 
145                 150                 155                 160


Ser Val Leu Val Thr Ala Ser Val Lys Glu Ala Ala Glu Ala Phe Leu 
                165                 170                 175


Gly Phe Ser Tyr Ala Pro Pro Thr Asp Ser Phe Leu 
            180                 185


<210>  3360
<211>  4566
<212>  DNA
<213>  Homo sapiens

<400>  3360
taacagaaca gggatagccg tctctggctc gtgctctcat gtcatctcag agttccagct     60

tatcagaggc atgtagcagg gaggcttatt ccagccataa ctgggctcta cctccagcct    120

ccagaagtaa tccccaacct gcatatcctt gggcaacccg aagaatgaaa gaagaagcta    180

taaaaccccc tttgaaagct ttcatgaagc agaggaggat gggtctgaac gactttattc    240

agaagattgc caataactcc tatgcatgca aacaccctga agttcagtcc atcttgaaga    300

tctcccaacc tcaggagcct gagcttatga atgccaaccc ttctcctcca ccaagtcctt    360

ctcagcaaat caaccttggc ccgtcgtcca atcctcatgc taaaccatct gactttcact    420

tcttgaaagt gatcggaaag ggcagttttg gaaaggttct tctagcaaga cacaaggcag    480

aagaagtgtt ctatgcagtc aaagttttac agaagaaagc aatcctgaaa aagaaagagg    540

tatgagatgt gcttgatggg gctggcattg gcggtagaca ctccttgaat aatcttgatt    600

ctggaatgtt ggtgccaagt tgaaacatgc cactaaatct gaatcgtcat tttcctagga    660

gaagcatatt atgtcggagc ggaatgttct gttgaagaat gtgaagcacc ctttcctggt    720

gggccttcac ttctctttcc agactgctga caaattgtac tttgtcctag actacattaa    780

tggtggagag gtgagcaggg gggatagaag tcaactctta gtgtctctgc acagcctgct    840

ttgttttagt ttgagaaaaa agttttcaaa gatttttggt ggggagaatg ttaccagaat    900

tagcatttcc ttcaacctgt caggtttata gttaatagat tacttggggc cacttcctgc    960

agttgttctt ttgctgtgta tgtcaaaact aattaaattc atttgcaacc cagaatgact   1020

ttgttctgtc tcctgcagtt gttctaccat ctccagaggg aacgctgctt cctggaacca   1080

cgggctcgtt tctatgctgc tgaaatagcc agtgccttgg gctacctgca ttcactgaac   1140

atcgtttata ggtaagcctg agagctcttc aggctaccag ttttggtata aaggagacgt   1200

agcactggct gtttcatagg gccttaaaat aatttgtgtt tatttgcaac ttggttgcct   1260

aaaaccagat cccctagcac gtgagctggc ttgacttaag tgccaagggg gaaccagcca   1320

agtaggattg tgcctaatcc agaatagatg agcagaacaa gggctccctt ttttcttcac   1380

tacacaacta cagtgaacct aaaatgcctc taataccttt agcaattatc tttaagagga   1440

tatcttatga agtgaaatta acttgtgcaa ctacttttct attcactttt ttacagagac   1500

ttaaaaccag agaatatttt gctagattca cagggacaca ttgtccttac tgacttcgga   1560

ctctgcaagg agaacattga acacaacagc acaacatcca ccttctgtgg cacgccggag   1620

gtaggcgctg tcttggtttg gtgcctggtt tacccccgcc ttccaagaga gagatgtaca   1680

atcatgcact taactaccaa aaagagtaaa ctcctctcag agacttctta atacagttca   1740

gtgcaaataa aatacatttg ctgtttgatg tagcatgaga aatcccaagt ccttctgttc   1800

ctttactgaa aagtagctgt ttgtaagtaa gatctgcatc ataaaaactt tctaaatccc   1860

taagtaagag atatcaagtg cccagcagtt tcctaaatgt cagtacacat aggtagccag   1920

tcaccctcaa aaagtccagc agttttatca ggaaggaatc taaagatatc tatcttccaa   1980

gctggctctg ggtctctcag ctttttcaaa ctaaatgtgt ggtcgtggga ttgcttgctt   2040

tcgcaggttc taaacgctgt ttccctggtc tgtttttcag tatctcgcac ctgaggtgct   2100

tcataagcag ccttatgaca ggactgtgga ctggtggtgc ctgggagctg tcttgtatga   2160

gatgctgtat ggcctggtga gtggcacatt gggaaccatg gaacactgcc tgctccctac   2220

aatattgcct tcacacagcc catgcttggc catggtgtct tgcccttacc agtacgctta   2280

tcaaaagcag ctaagaggca tattggttat tttatagttc ataagaataa tcacttacct   2340

ggttcttttg tgcatttcac attttactag ataggaccac attgaacctg tgtggtggtg   2400

aaaaactacc acttattaac atctaccccc tcaccctcca cacacacaca cacaaacaca   2460

cacacgggtt gcaaagtaga cacttaaata gcaagggaaa agaaagcatt gaggtgggga   2520

gagtttctca aatcgagcct aatatttatt gccgtttata tctttttctc tactggtaat   2580

gtgtgccata tgaaacttcc aattaagtct aaagtaattt tccccttctt tcagccgcct   2640

ttttatagcc gaaacacagc tgaaatgtac gacaacattc tgaacaagcc tctccagctg   2700

aaaccaaata ttacaaattc cgcaagacac ctcctggagg gcctcctgca gaaggacagg   2760

acaaagcggc tcggggccaa ggatgacttc gtgagtgatg ttttcctgtc ctcctgggcc   2820

ggccgggacg tgcactagac ctccctgccc ttattgaatg cacctgtcta aattaatctt   2880

gggtttctta tcaacagatg gagattaaga gtcatgtctt cttctcctta attaactggg   2940

atgatctcat taataagaag attactcccc cttttaaccc aaatgtggtg agtatctgtc   3000

tctcttctaa gtatagagaa gcccaaaggg catttatttt aattcagaat tgtctggggg   3060

agggttggaa ggaatacatt ggcagatgtt ttctccataa acctgttatt ttacctacat   3120

aaaaagcaca tttttgtgtc ccaacaaggc tcccataatt tttagacaca tttatcaatt   3180

cgaagcacca aaaggcaaca agtgaacatt attcttatgt ttaactgtgt gtagcctttt   3240

gagattttgt gcttgaagtg ggtgattatg gaagttgata taagacttaa acttggtatt   3300

taaagcctgg tcaagatttc cctgtcctgt gtctagtgtg agttcttgac aagagtgttt   3360

ttcccttccc gtcacagagt gggcccaacg acctacggca ctttgacccc gagtttaccg   3420

aagagcctgt ccccaactcc attggcaagt cccctgacag cgtcctcgtc acagccagcg   3480

tcaaggaagc tgccgaggct ttcctaggct tttcctatgc gcctcccacg gactctttcc   3540

tctgaaccct gttagggctt ggttttaaag gattttatgt gtgtttccga atgttttagt   3600

tagccttttg gtggagccgc cagctgacag gacatcttac aagagaattt gcacatctct   3660

ggaagcttag caatcttatt gcacactgtt cgctggaagc tttttgaaga gcacattctc   3720

ctcagtgagc tcatgaggtt ttcattttta ttcttccttc caacgtggtg ctatctctga   3780

aacgagcgtt agagtgccgc cttagacgga ggcaggagtt tcgttagaaa gcggacgctg   3840

ttctaaaaaa ggtctcctgc agatctgtct gggctgtgat gacgaatatt atgaaatgtg   3900

ccttttctga agagattgtg ttagctccaa agcttttcct atcgcagtgt ttcagttctt   3960

tattttccct tgtggatatg ctgtgtgaac cgtcgtgtga gtgtggtatg cctgatcaca   4020

gatggatttt gttataagca tcaatgtgac acttgcagga cactacaacg tgggacattg   4080

tttgtttctt ccatatttgg aagataaatt tatgtgtaga cttttttgta agatacggtt   4140

aataactaaa atttattgaa atggtcttgc aatgactcgt attcagatgc ttaaagaaag   4200

cattgctgct acaaatattt ctatttttag aaagggtttt tatggaccaa tgccccagtt   4260

gtcagtcaga gccgttggtg tttttcattg tttaaaatgt cacctgtaaa atgggcatta   4320

tttatgtttt tttttttgca ttcctgataa ttgtatgtat tgtataaaga acgtctgtac   4380

attgggttat aacactagta tatttaaact tacaggctta tttgtaatgt aaaccaccat   4440

tttaatgtac tgtaattaac atggttataa tacgtacaat ccttccctca tcccatcaca   4500

caactttttt tgtgtgtgat aaactgattt tggtttgcaa taaaaccttg aaaaatattt   4560

acatat                                                              4566


<210>  3361
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  3361

Met Ser Ser Gln Ser Ser Ser Leu Ser Glu Ala Cys Ser Arg Glu Ala 
1               5                   10                  15


Tyr Ser Ser His Asn Trp Ala Leu Pro Pro Ala Ser Arg Ser Asn Pro 
            20                  25                  30


Gln Pro Ala Tyr Pro Trp Ala Thr Arg Arg Met Lys Glu Glu Ala Ile 
        35                  40                  45


Lys Pro Pro Leu Lys Ala Phe Met Lys Gln Arg Arg Met Gly Leu Asn 
    50                  55                  60


Asp Phe Ile Gln Lys Ile Ala Asn Asn Ser Tyr Ala Cys Lys His Pro 
65                  70                  75                  80


Glu Val Gln Ser Ile Leu Lys Ile Ser Gln Pro Gln Glu Pro Glu Leu 
                85                  90                  95


Met Asn Ala Asn Pro Ser Pro Pro Pro Ser Pro Ser Gln Gln Ile Asn 
            100                 105                 110


Leu Gly Pro Ser Ser Asn Pro His Ala Lys Pro Ser Asp Phe His Phe 
        115                 120                 125


Leu Lys Val Ile Gly Lys Gly Ser Phe Gly Lys Val Leu Leu Ala Arg 
    130                 135                 140


His Lys Ala Glu Glu Val Phe Tyr Ala Val Lys Val Leu Gln Lys Lys 
145                 150                 155                 160


Ala Ile Leu Lys Lys Lys Glu Val 
                165


<210>  3362
<211>  3254
<212>  DNA
<213>  Homo sapiens

<400>  3362
aactgctctt cagtgtgccc tgagccggct gtgccttctc tccatccgct gctcagatat     60

tcatgaaccg ttgcttcttc cagcctcgcc ttctcgctcc ctctgccttt ctggcgctgt    120

tctccctccc tccctctggc ttctgctctt tcttactcct tctctcagct gcttaactac    180

agctcccact ggaacttgca caatcaaaaa caactctcct ctctcaagcc gcctccagga    240

gcgcatcacc tggagaagag cgactcgctc cccgcgccgg ccgcggaaga gcagccaggt    300

agctgggggc ggggaggcgt acccttctcc cgctcggtaa gagccacagc atctccccgg    360

agattggccg tatcccaccg tccggccccc agggtcctgc agcggtgatg catatgtttc    420

ggagcaatga tggaaggaga aaagccgctg tcggtggcaa ctgaaagtgg ggagaggttg    480

ctgcagtagc tggtgctgca gaatgcgcga gtgaagaact gagccccgct agattctcca    540

tcccgctcag tcttcattaa ctgtctgcag gaggtaaacc ggggaaacag atatgcacta    600

accaggcggg tgccaacctg gatctataac tgtgaattcc ccacggtgga aaatggtaaa    660

caaagacatg aatggattcc cagtcaagaa atgctcagcc ttccaatttt ttaagaagcg    720

ggtacgaagg tggatcaaga gcccaatggt cagtgtggac aagcatcaga gtcccagcct    780

gaagtacacc ggctcctcca tggtgcacat ccctccaggg gagccagact tcgagtcttc    840

cttgtgtcaa acatgcctgg gtgaacatgc tttccaaaga ggggttctcc ctcaggagaa    900

cgagtcatgt tcatgggaaa ctcaatctgg gtgtgaagtg agagagccat gtaatcatgc    960

caacatcctg accaagcccg atccaagaac cttctggact aatgatgatc cagctttcat   1020

gaagcagagg aggatgggtc tgaacgactt tattcagaag attgccaata actcctatgc   1080

atgcaaacac cctgaagttc agtccatctt gaagatctcc caacctcagg agcctgagct   1140

tatgaatgcc aacccttctc ctccaccaag tccttctcag caaatcaacc ttggcccgtc   1200

gtccaatcct catgctaaac catctgactt tcacttcttg aaagtgatcg gaaagggcag   1260

ttttggaaag gttcttctag caagacacaa ggcagaagaa gtgttctatg cagtcaaagt   1320

tttacagaag aaagcaatcc tgaaaaagaa agaggagaag catattatgt cggagcggaa   1380

tgttctgttg aagaatgtga agcacccttt cctggtgggc cttcacttct ctttccagac   1440

tgctgacaaa ttgtactttg tcctagacta cattaatggt ggagagttgt tctaccatct   1500

ccagagggaa cgctgcttcc tggaaccacg ggctcgtttc tatgctgctg aaatagccag   1560

tgccttgggc tacctgcatt cactgaacat cgtttataga gacttaaaac cagagaatat   1620

tttgctagat tcacagggac acattgtcct tactgacttc ggactctgca aggagaacat   1680

tgaacacaac agcacaacat ccaccttctg tggcacgccg gagtatctcg cacctgaggt   1740

gcttcataag cagccttatg acaggactgt ggactggtgg tgcctgggag ctgtcttgta   1800

tgagatgctg tatggcctgc cgccttttta tagccgaaac acagctgaaa tgtacgacaa   1860

cattctgaac aagcctctcc agctgaaacc aaatattaca aattccgcaa gacacctcct   1920

ggagggcctc ctgcagaagg acaggacaaa gcggctcggg gccaaggatg acttcatgga   1980

gattaagagt catgtcttct tctccttaat taactgggat gatctcatta ataagaagat   2040

tactccccct tttaacccaa atgtgagtgg gcccaacgac ctacggcact ttgaccccga   2100

gtttaccgaa gagcctgtcc ccaactccat tggcaagtcc cctgacagcg tcctcgtcac   2160

agccagcgtc aaggaagctg ccgaggcttt cctaggcttt tcctatgcgc ctcccacgga   2220

ctctttcctc tgaaccctgt tagggcttgg ttttaaagga ttttatgtgt gtttccgaat   2280

gttttagtta gccttttggt ggagccgcca gctgacagga catcttacaa gagaatttgc   2340

acatctctgg aagcttagca atcttattgc acactgttcg ctggaagctt tttgaagagc   2400

acattctcct cagtgagctc atgaggtttt catttttatt cttccttcca acgtggtgct   2460

atctctgaaa cgagcgttag agtgccgcct tagacggagg caggagtttc gttagaaagc   2520

ggacgctgtt ctaaaaaagg tctcctgcag atctgtctgg gctgtgatga cgaatattat   2580

gaaatgtgcc ttttctgaag agattgtgtt agctccaaag cttttcctat cgcagtgttt   2640

cagttcttta ttttcccttg tggatatgct gtgtgaaccg tcgtgtgagt gtggtatgcc   2700

tgatcacaga tggattttgt tataagcatc aatgtgacac ttgcaggaca ctacaacgtg   2760

ggacattgtt tgtttcttcc atatttggaa gataaattta tgtgtagact tttttgtaag   2820

atacggttaa taactaaaat ttattgaaat ggtcttgcaa tgactcgtat tcagatgctt   2880

aaagaaagca ttgctgctac aaatatttct atttttagaa agggttttta tggaccaatg   2940

ccccagttgt cagtcagagc cgttggtgtt tttcattgtt taaaatgtca cctgtaaaat   3000

gggcattatt tatgtttttt tttttgcatt cctgataatt gtatgtattg tataaagaac   3060

gtctgtacat tgggttataa cactagtata tttaaactta caggcttatt tgtaatgtaa   3120

accaccattt taatgtactg taattaacat ggttataata cgtacaatcc ttccctcatc   3180

ccatcacaca actttttttg tgtgtgataa actgattttg gtttgcaata aaaccttgaa   3240

aaatatttac atat                                                     3254


<210>  3363
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  3363

Met Val Asn Lys Asp Met Asn Gly Phe Pro Val Lys Lys Cys Ser Ala 
1               5                   10                  15


Phe Gln Phe Phe Lys Lys Arg Val Arg Arg Trp Ile Lys Ser Pro Met 
            20                  25                  30


Val Ser Val Asp Lys His Gln Ser Pro Ser Leu Lys Tyr Thr Gly Ser 
        35                  40                  45


Ser Met Val His Ile Pro Pro Gly Glu Pro Asp Phe Glu Ser Ser Leu 
    50                  55                  60


Cys Gln Thr Cys Leu Gly Glu His Ala Phe Gln Arg Gly Val Leu Pro 
65                  70                  75                  80


Gln Glu Asn Glu Ser Cys Ser Trp Glu Thr Gln Ser Gly Cys Glu Val 
                85                  90                  95


Arg Glu Pro Cys Asn His Ala Asn Ile Leu Thr Lys Pro Asp Pro Arg 
            100                 105                 110


Thr Phe Trp Thr Asn Asp Asp Pro Ala Phe Met Lys Gln Arg Arg Met 
        115                 120                 125


Gly Leu Asn Asp Phe Ile Gln Lys Ile Ala Asn Asn Ser Tyr Ala Cys 
    130                 135                 140


Lys His Pro Glu Val Gln Ser Ile Leu Lys Ile Ser Gln Pro Gln Glu 
145                 150                 155                 160


Pro Glu Leu Met Asn Ala Asn Pro Ser Pro Pro Pro Ser Pro Ser Gln 
                165                 170                 175


Gln Ile Asn Leu Gly Pro Ser Ser Asn Pro His Ala Lys Pro Ser Asp 
            180                 185                 190


Phe His Phe Leu Lys Val Ile Gly Lys Gly Ser Phe Gly Lys Val Leu 
        195                 200                 205


Leu Ala Arg His Lys Ala Glu Glu Val Phe Tyr Ala Val Lys Val Leu 
    210                 215                 220


Gln Lys Lys Ala Ile Leu Lys Lys Lys Glu Glu Lys His Ile Met Ser 
225                 230                 235                 240


Glu Arg Asn Val Leu Leu Lys Asn Val Lys His Pro Phe Leu Val Gly 
                245                 250                 255


Leu His Phe Ser Phe Gln Thr Ala Asp Lys Leu Tyr Phe Val Leu Asp 
            260                 265                 270


Tyr Ile Asn Gly Gly Glu Leu Phe Tyr His Leu Gln Arg Glu Arg Cys 
        275                 280                 285


Phe Leu Glu Pro Arg Ala Arg Phe Tyr Ala Ala Glu Ile Ala Ser Ala 
    290                 295                 300


Leu Gly Tyr Leu His Ser Leu Asn Ile Val Tyr Arg Asp Leu Lys Pro 
305                 310                 315                 320


Glu Asn Ile Leu Leu Asp Ser Gln Gly His Ile Val Leu Thr Asp Phe 
                325                 330                 335


Gly Leu Cys Lys Glu Asn Ile Glu His Asn Ser Thr Thr Ser Thr Phe 
            340                 345                 350


Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val Leu His Lys Gln Pro 
        355                 360                 365


Tyr Asp Arg Thr Val Asp Trp Trp Cys Leu Gly Ala Val Leu Tyr Glu 
    370                 375                 380


Met Leu Tyr Gly Leu Pro Pro Phe Tyr Ser Arg Asn Thr Ala Glu Met 
385                 390                 395                 400


Tyr Asp Asn Ile Leu Asn Lys Pro Leu Gln Leu Lys Pro Asn Ile Thr 
                405                 410                 415


Asn Ser Ala Arg His Leu Leu Glu Gly Leu Leu Gln Lys Asp Arg Thr 
            420                 425                 430


Lys Arg Leu Gly Ala Lys Asp Asp Phe Met Glu Ile Lys Ser His Val 
        435                 440                 445


Phe Phe Ser Leu Ile Asn Trp Asp Asp Leu Ile Asn Lys Lys Ile Thr 
    450                 455                 460


Pro Pro Phe Asn Pro Asn Val Ser Gly Pro Asn Asp Leu Arg His Phe 
465                 470                 475                 480


Asp Pro Glu Phe Thr Glu Glu Pro Val Pro Asn Ser Ile Gly Lys Ser 
                485                 490                 495


Pro Asp Ser Val Leu Val Thr Ala Ser Val Lys Glu Ala Ala Glu Ala 
            500                 505                 510


Phe Leu Gly Phe Ser Tyr Ala Pro Pro Thr Asp Ser Phe Leu 
        515                 520                 525


<210>  3364
<211>  592
<212>  DNA
<213>  Homo sapiens

<400>  3364
gcagcatacg ccgagccggt ctttgagcgc taacgtcttt ctgtctcccc gcggtggtga     60

tgacggtgaa aactgaggct gctaagggca ccctcactta ctccaggatg aggggcatgg    120

tggcaattct catcgctttc atgaagcaga ggaggatggg tctgaacgac tttattcaga    180

agattgccaa taactcctat gcatgcaaac accctgaagt tcagtccatc ttgaagatct    240

cccaacctca ggagcctgag cttatgaatg ccaacccttc tcctccagta agtttttgta    300

tgtgccgtgc atctgtggag aactgtaagg gagtcagtta gtattcctac attaatggat    360

taaaatagca tttctagaaa ttagtatcaa ggcaggaatg cttcattatg gcataacaag    420

tgatataaat atttaagtat tgagtcagag tattatttta tttttttcct gggcatattt    480

tacctccaaa gtggttattt taaaaggcat atttcataaa aaggttttat ctgtctgaaa    540

caacatgact gtgtgcagtt tccatactca tttgaaatgt gatgaaatgt ag            592


<210>  3365
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  3365

Met Thr Val Lys Thr Glu Ala Ala Lys Gly Thr Leu Thr Tyr Ser Arg 
1               5                   10                  15


Met Arg Gly Met Val Ala Ile Leu Ile Ala Phe Met Lys Gln Arg Arg 
            20                  25                  30


Met Gly Leu Asn Asp Phe Ile Gln Lys Ile Ala Asn Asn Ser Tyr Ala 
        35                  40                  45


Cys Lys His Pro Glu Val Gln Ser Ile Leu Lys Ile Ser Gln Pro Gln 
    50                  55                  60


Glu Pro Glu Leu Met Asn Ala Asn Pro Ser Pro Pro Val Ser Phe Cys 
65                  70                  75                  80


Met Cys Arg Ala Ser Val Glu Asn Cys Lys Gly Val Ser 
                85                  90


<210>  3366
<211>  541
<212>  DNA
<213>  Homo sapiens

<400>  3366
atagccgtct ctggctcgtg ctctcatgtc atctcagagt tccagcttat cagaggcatg     60

tagcagggag gcttattcca gccataactg ggctctacct ccagcctcca gaagtaatcc    120

ccaacctgca tatccttggg caacccgaag aatgaaagaa gaagctataa aacccccttt    180

gaaagctttc atgaagcaga ggaggatggg tctgaacgac tttattcaga agattgccaa    240

taactcctat gcatgcaaac accctgaagt tcagtccatc ttgaagatct cccaacctca    300

ggagcctgag cttatgaatg ccaacccttc tcctccagta agtttttgta tgtgccgtgc    360

atctgtggag aactgtaagg gagtcagtta gtattcctac attaatggat taaaatagca    420

tttctagaaa ttagtatcaa ggcaggaatg cttcattatg gcataacaag tgatataaat    480

atttaagtat tgagtcagag tattatttta tttttttcct gggcatattt tacctccaaa    540

g                                                                    541


<210>  3367
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  3367

Met Ser Ser Gln Ser Ser Ser Leu Ser Glu Ala Cys Ser Arg Glu Ala 
1               5                   10                  15


Tyr Ser Ser His Asn Trp Ala Leu Pro Pro Ala Ser Arg Ser Asn Pro 
            20                  25                  30


Gln Pro Ala Tyr Pro Trp Ala Thr Arg Arg Met Lys Glu Glu Ala Ile 
        35                  40                  45


Lys Pro Pro Leu Lys Ala Phe Met Lys Gln Arg Arg Met Gly Leu Asn 
    50                  55                  60


Asp Phe Ile Gln Lys Ile Ala Asn Asn Ser Tyr Ala Cys Lys His Pro 
65                  70                  75                  80


Glu Val Gln Ser Ile Leu Lys Ile Ser Gln Pro Gln Glu Pro Glu Leu 
                85                  90                  95


Met Asn Ala Asn Pro Ser Pro Pro Val Ser Phe Cys Met Cys Arg Ala 
            100                 105                 110


Ser Val Glu Asn Cys Lys Gly Val Ser 
        115                 120


<210>  3368
<211>  520
<212>  DNA
<213>  Homo sapiens

<400>  3368
atacgccgag ccggtctttg agcgctaacg tctttctgtc tccccgcggt ggtgatgacg     60

gtgaaaactg aggctgctaa gggcaccctc acttactcca ggatgagggg catggtggca    120

attctcatcg gtgagtgcag gaatcttgcg ggacttctgc tccaggagac gcaaagtgga    180

aattttttga aagtcccgga tcagattagt gtgtgtggcg ccggacgtta tgaagccgtc    240

taaacgtttc tttatttctc ctccttcatc cacagctttc atgaagcaga ggaggatggg    300

tctgaacgac tttattcaga agattgccaa taactcctat gcatgcaaac accctgaagt    360

tcagtccatc ttgaagatct cccaacctca ggagcctgag cttatgaatg ccaacccttc    420

tcctccagta agtttttgta tgtgccgtgc atctgtggag aactgtaagg gagtcagtta    480

gtattcctac attaatggat taaaatagca tttctagaaa                          520


<210>  3369
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  3369

Met Lys Pro Ser Lys Arg Phe Phe Ile Ser Pro Pro Ser Ser Thr Ala 
1               5                   10                  15


Phe Met Lys Gln Arg Arg Met Gly Leu Asn Asp Phe Ile Gln Lys Ile 
            20                  25                  30


Ala Asn Asn Ser Tyr Ala Cys Lys His Pro Glu Val Gln Ser Ile Leu 
        35                  40                  45


Lys Ile Ser Gln Pro Gln Glu Pro Glu Leu Met Asn Ala Asn Pro Ser 
    50                  55                  60


Pro Pro Val Ser Phe Cys Met Cys Arg Ala Ser Val Glu Asn Cys Lys 
65                  70                  75                  80


Gly Val Ser 



<210>  3370
<211>  3075
<212>  DNA
<213>  Homo sapiens

<400>  3370
aactgctctt cagtgtgccc tgagccggct gtgccttctc tccatccgct gctcagatat     60

tcatgaaccg ttgcttcttc cagcctcgcc ttctcgctcc ctctgccttt ctggcgctgt    120

tctccctccc tccctctggc ttctgctctt tcttactcct tctctcagct gcttaactac    180

agctcccact ggaacttgca caatcaaaaa caactctcct ctctcaagcc gcctccagga    240

gcgcatcacc tggagaagag cgactcgctc cccgcgccgg ccgcggaaga gcagccaggt    300

agctgggggc ggggaggcgt acccttctcc cgctcggtaa gagccacagc atctccccgg    360

agattggccg tatcccaccg tccggccccc agggtcctgc agcggtgatg catatgtttc    420

ggagcaatga tggaaggaga aaagccgctg tcggtggcaa ctgaaagtgg ggagaggttg    480

ctgcagtagc tggtgctgca gaatgcgcga gtgaagaact gagccccgct agattctcca    540

tcccgctcag tcttcattaa ctgtctgcag gaggtaaacc ggggaaacag atatgcacta    600

accaggcggg tgccaacctg gatctataac tgtgaattcc ccacggtgga aaatggtaaa    660

caaagacatg aatggattcc cagtcaagaa atgctcagcc ttccaatttt ttaagaagcg    720

ggtacgaagg tggatcaaga gcccaatggt cagtgtggac aagcatcaga gtcccagcct    780

gaagtacacc ggctcctcca tggtgcacat ccctccaggg gagccagact tcgagtcttc    840

cttgtgtcaa acatgcctgg gtgaacatgc tttccaaaga ggggttctcc ctcaggagaa    900

cgagtcatgt tcatgggaaa ctcaatctgg gtgtgaagta agttcatgtt cgctctggat    960

ctattctcct ggaaaaattc tgggcctttg tttttcttgt atttctgcca gagtataccc   1020

aaaaaataat tttttaatgc atatttataa agcttctgag gaagacctag aattgtggtc   1080

tttgttagct cattatgtta tttttttaaa gtaggcttta tattttagag cagctttaag   1140

ttcacagcaa cattgagcag aaggtacaga gattacccat atacgcttgt ccccatgcac   1200

gtataaccta ctttgccatc aacattccct agcagagttt tatgttagag ttcactcttg   1260

gtgttataca ttctatgggt ttggactaat gtataataac atgcatccac cattacagta   1320

tcatacagtt aagtttcact gccctaaaaa tcctctgccc tccactattc atcccctcct   1380

taccctgacc cctagcaacc actgatcttt ttactgtctc catagatttg ccttttccag   1440

aatgtcatct agctgaatca tgcagtatgt tgtattaatg ttttacgtgg gtccaagact   1500

gatacagcaa tgtgttggta aactggcaat tcctcagaag tggtttgatc acacaggaga   1560

tcaagtctta gatgatacaa cgattgtaat agtcatctac atgttcgtag cttccattga   1620

aatatttagt tcaacacgat ttgatccatt tacagagcac tatgtatact tttcattatt   1680

tttctcaagc tcatatatac tcacattttt actaagactt attttccctg ctactccaag   1740

agttgttttt taaaaatttt gttaatccaa gaaaaccaga taactgattc atcttgcagt   1800

ttctaagatt tcaaaaattt aagattatat ttttaactta taacttaatt aggcccatat   1860

ttattttgat ttttaaaacc attatataaa atgcttatat tatttttacc atcatactga   1920

cataaaaata caatatttag aagacagaac atgttattac aaagtacagt taattgtaag   1980

tgatcttcca agtcagtgca tcatagaatg ataaacgtta ataaccgctc acctttttta   2040

tttttagcaa ggtaaccatt ttccagagat aaaataatca tttagctgct aaaagactga   2100

agacattaaa tctgagttcc ttttcactct gagttatcac gcaatgtcgc tgaatctgtt   2160

tcataatttg tctactttct ttctttcttt tttttttttt tttgagtttc actcttgttg   2220

cccagactgg agtgcaatgg cacgatctcg gctcactgca acctccgctt cctgagttca   2280

agtaattctt ctgcctcagt ctcccgagta gctgggatta caggcaccca acaccacgcc   2340

tggctaattt ttgtattttt aatagaaaca gggtttctct atgttggtca ggctggtgtc   2400

aaactcccaa cctcaggtaa tccacctgcg tcggctttcc aaattgctgg gattacaggc   2460

atgagccact acgccggccc tttttttggg gggggtgggg gtcggggaca gggagacagg   2520

gggacagagt cttgctctgt aaccctgact tgagtgcagt agtgcaatca taactcactg   2580

ttacctcaaa ctcctaggtt caagtgatcc tcccacctca accctcccaa gtaaataaga   2640

ccacaggcat acgccaacaa acctggctaa ttaaaaaaaa aaaatttttt ttgtagaaac   2700

agggtgttgt catactgacc aggctggtct tgaactcctg gcttcaagtg atcctcccaa   2760

aatgctggga ttataggtat gaggcacaat gcccagccta cttgtctact ttctacggtt   2820

attggaaaaa tcaaatgaga ttgatatgaa atgtttcata atctatagaa tgccatgcaa   2880

atataaatca ttattgctca tgtttgctga tttacatatt agctaagcct gtgactctgt   2940

aacactatat tagacttcca taactgggtt agcactttgc tgatccatga acatttgtca   3000

tggtgcattt gctttttagc cagatgttgg ttcaactcta ggtttgtcat gaaaaacaat   3060

aaagacgcta aatgc                                                    3075


<210>  3371
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  3371

Met Val Asn Lys Asp Met Asn Gly Phe Pro Val Lys Lys Cys Ser Ala 
1               5                   10                  15


Phe Gln Phe Phe Lys Lys Arg Val Arg Arg Trp Ile Lys Ser Pro Met 
            20                  25                  30


Val Ser Val Asp Lys His Gln Ser Pro Ser Leu Lys Tyr Thr Gly Ser 
        35                  40                  45


Ser Met Val His Ile Pro Pro Gly Glu Pro Asp Phe Glu Ser Ser Leu 
    50                  55                  60


Cys Gln Thr Cys Leu Gly Glu His Ala Phe Gln Arg Gly Val Leu Pro 
65                  70                  75                  80


Gln Glu Asn Glu Ser Cys Ser Trp Glu Thr Gln Ser Gly Cys Glu Val 
                85                  90                  95


Ser Ser Cys Ser Leu Trp Ile Tyr Ser Pro Gly Lys Ile Leu Gly Leu 
            100                 105                 110


Cys Phe Ser Cys Ile Ser Ala Arg Val Tyr Pro Lys Asn Asn Phe Leu 
        115                 120                 125


Met His Ile Tyr Lys Ala Ser Glu Glu Asp Leu Glu Leu Trp Ser Leu 
    130                 135                 140


Leu Ala His Tyr Val Ile Phe Leu Lys 
145                 150


<210>  3372
<211>  984
<212>  DNA
<213>  Homo sapiens

<400>  3372
actgctcttc agtgtgccct gagccggctg tgccttctct ccatccgctg ctcagatatt     60

catgaaccgt tgcttcttcc agcctcgcct tctcgctccc tctgcctttc tggcgctgtt    120

ctccctccct ccctctggct tctgctcttt cttactcctt ctctcagctg cttaactaca    180

gctcccactg gaacttgcac aatcaaaaac aactctcctc tctcaagccg cctccaggag    240

cgcatcacct ggagaagagc gactcgctcc ccgcgccggc cgcggaagag cagccaggta    300

gctgggggcg gggaggcgta cccttctccc gctcggtaag agccacagca tctccccgga    360

gattggccgt atcccaccgt ccggccccca gggtcctgca gcggtgatgc atatgtttcg    420

gagcaatgat ggaaggagaa aagccgctgt cggtggcaac tgaaagtggg gagaggttgc    480

tgcagtagct ggtgctgcag aatgcgcgag tgaagaactg agccccgcta gattctccat    540

cccgctcagt cttcattaac tgtctgcagg aggtaaaccg gggaaacaga tatgcactaa    600

ccaggcgggt gccaacctgg atctataact gtgaattccc cacggtggaa aatggtaaac    660

aaagacatga atggattccc agtcaagaaa tgctcagcct tccaattttt taagaagcgg    720

gatcttgctc tgtcccccag actggagagt agtggtgcga tgattgctca ctttaacctt    780

gaacttcaag actcaagtga tcctccctat tgcccaggct ggaatgcagt ggtgcaatct    840

ccactcactg caacctccgc ctcccagatt caagcaattc tcctgcctca gtctgccacc    900

acacccggct aacttttata tctttagtag agacgtggtt tcaccttgtt ggccttgctg    960

gtctcaaact cctgacctcg agtg                                           984


<210>  3373
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  3373

Met Val Asn Lys Asp Met Asn Gly Phe Pro Val Lys Lys Cys Ser Ala 
1               5                   10                  15


Phe Gln Phe Phe Lys Lys Arg Asp Leu Ala Leu Ser Pro Arg Leu Glu 
            20                  25                  30


Ser Ser Gly Ala Met Ile Ala His Phe Asn Leu Glu Leu Gln Asp Ser 
        35                  40                  45


Ser Asp Pro Pro Tyr Cys Pro Gly Trp Asn Ala Val Val Gln Ser Pro 
    50                  55                  60


Leu Thr Ala Thr Ser Ala Ser Gln Ile Gln Ala Ile Leu Leu Pro Gln 
65                  70                  75                  80


Ser Ala Thr Thr Pro Gly 
                85


<210>  3374
<211>  844
<212>  DNA
<213>  Homo sapiens

<400>  3374
aactgctctt cagtgtgccc tgagccggct gtgccttctc tccatccgct gctcagatat     60

tcatgaaccg ttgcttcttc cagcctcgcc ttctcgctcc ctctgccttt ctggcgctgt    120

tctccctccc tccctctggc ttctgctctt tcttactcct tctctcagct gcttaactac    180

agctcccact ggaacttgca caatcaaaaa caactctcct ctctcaagcc gcctccagga    240

gcgcatcacc tggagaagag cgactcgctc cccgcgccgg ccgcggaaga gcagccaggt    300

agctgggggc ggggaggcgt acccttctcc cgctcggtaa gagccacagc atctccccgg    360

agattggccg tatcccaccg tccggccccc agggtcctgc agcggtgatg catatgtttc    420

ggagcaatga tggaaggaga aaagccgctg tcggtggcaa ctgaaagtgg ggagaggttg    480

ctgcagtagc tggtgctgca gaatgcgcga gtgaagaact gagccccgct agattctcca    540

tcccgctcag tcttcattaa ctgtctgcag gaggtaaacc ggggaaacag atatgcacta    600

accaggcggg tgccaacctg gatctataac tgtgaattcc ccacggtgga aaatggtaaa    660

caaagacatg aatggattcc cagtcaagaa atgctcagcc ttccaatttt ttaagaagcg    720

gagacggggt cttgctatat tgcccagggt ggtcttgacc ttttgggctc aagtggtcct    780

cctgcctcag cctcccaaat tgctgggatt acagatgtcc accaccaggc ccagccctaa    840

tttt                                                                 844


<210>  3375
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  3375

Met Val Asn Lys Asp Met Asn Gly Phe Pro Val Lys Lys Cys Ser Ala 
1               5                   10                  15


Phe Gln Phe Phe Lys Lys Arg Arg Arg Gly Leu Ala Ile Leu Pro Arg 
            20                  25                  30


Val Val Leu Thr Phe Trp Ala Gln Val Val Leu Leu Pro Gln Pro Pro 
        35                  40                  45


Lys Leu Leu Gly Leu Gln Met Ser Thr Thr Arg Pro Ser Pro Asn 
    50                  55                  60


<210>  3376
<211>  210
<212>  DNA
<213>  Homo sapiens

<400>  3376
atggcccgga tagcaaccac tggagctggc gtggggtaca cggtgggtca taccatcact     60

gggggcttca atgaaggaag taatgctgag cctgcaagtc ctgacatcac ctaccaggag    120

ccccagggaa cccagatgtc acagcggcag cagccttgct tctatgagat aaaaccgttt    180

ttggagtgtg cccggaaccg ggtgacataa                                     210


<210>  3377
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  3377

Met Ala Arg Ile Ala Thr Thr Gly Ala Gly Val Gly Tyr Thr Val Gly 
1               5                   10                  15


His Thr Ile Thr Gly Gly Phe Asn Glu Gly Ser Asn Ala Glu Pro Ala 
            20                  25                  30


Ser Pro Asp Ile Thr Tyr Gln Glu Pro Gln Gly Thr Gln Met Ser Gln 
        35                  40                  45


Arg Gln Gln Pro Cys Phe Tyr Glu Ile Lys Pro Phe Leu Glu Cys Ala 
    50                  55                  60


Arg Asn Arg Val Thr 
65


<210>  3378
<211>  5476
<212>  DNA
<213>  Homo sapiens

<400>  3378
gcggcacaga gccgcggctt gctttcagga cacgggtcgc tggcgggtta ggtggctgcg     60

tggccgcctc acttcgcgca cgcgccgcta ggctggggga gttgatttgc actgctccgg    120

gtgtcggctc cggcgggacg ggcggttctg cgtacccctc tccgatcctg attgagtcaa    180

tgctttgcat tctcagtcct ctgcataaag ctgagagatg cctacagctg agagtgaagc    240

aaaagtaaaa accaaagttc gctttgaaga attgcttaag acccacagtg atctaatgcg    300

tgaaaagaaa aaactgaaga aaaaacttgt caggtctgaa gaaaacatct cacctgacac    360

tattagaagc aatcttcact atatgaaaga aactacaagt gatgatcccg acactattag    420

aagcaatctt ccccatatta aagaaactac aagtgatgat gtaagtgctg ctaacactaa    480

caacctgaag aagagcacga gagtcactaa aaacaaattg aggaacacac agttagcaac    540

tgaaaatcct aatggtgatg ctagtgtaga ggaagacaaa caaggaaagc caaataaaaa    600

ggtgataaag acggtgcccc agttgactac acaagacctg aaaccggaaa ctcctgagaa    660

taaggttgat tctacacacc agaaaacaca tacaaagcca cagccaggcg ttgatcatca    720

gaaaagtgag aaggcaaatg agggaagaga agagactgat ttagaagagg atgaagaatt    780

gatgcaagca tatcagtgcc atgtaactga agaaatggca aaggagatta agaggaaaat    840

aagaaagaaa ctgaaagaac agttgactta ctttccctca gatactttat tccatgatga    900

caaactaagc agtgaaaaaa ggaaaaagaa aaaggaagtt ccagtcttct ctaaagctga    960

aacaagtaca ttgaccatct ctggtgacac agttgaaggt gaacaaaaga aagaatcttc   1020

agttagatca gtttcttcag attctcatca agatgatgaa ataagctcaa tggaacaaag   1080

cacagaagac agcatgcaag atgatacaaa acctaaacca aaaaaaacaa aaaagaagac   1140

taaagcagtt gcagataata atgaagatgt tgatggtgat ggtgttcatg aaataacaag   1200

ccgagatagc ccggtttatc ccaaatgttt gcttgatgat gaccttgtct tgggagttta   1260

cattcaccga actgatagac ttaagtcaga ttttatgatt tctcacccaa tggtaaaaat   1320

tcatgtggtt gatgagcata ctggtcaata tgtcaagaaa gatgatagtg gacggcctgt   1380

ttcatcttac tatgaaaaag agaatgtgga ttatattctt cctattatga cccagccata   1440

tgattttaaa cagttaaaat caagacttcc agagtgggaa gaacaaattg tatttaatga   1500

aaattttccc tatttgcttc gaggctctga tgagagtcct aaagtcatcc tgttctttga   1560

gattcttgat ttcttaagcg tggatgaaat taagaataat tctgaggttc aaaaccaaga   1620

atgtggcttt cggaaaattg cctgggcatt tcttaagctt ctgggagcca atggaaatgc   1680

aaacatcaac tcaaaacttc gcttgcagct atattaccca cctactaagc ctcgatcccc   1740

attaagtgtt gttgaggcat ttgaatggtg gtcaaaatgt ccaagaaatc attacccatc   1800

aacactgtac gtaactgtaa gaggactgaa agttccagac tgtataaagc catcttaccg   1860

ctctatgatg gctcttcagg aggaaaaagg taaaccagtg cattgtgaac gtcaccatga   1920

gtcaagctca gtagacacag aacctggatt agaagagtca aaggaagtaa taaagtggaa   1980

acgactccct gggcaggctt gccgtatccc aaacaaacac ctcttctcac taaatgcagg   2040

agaacgagga tgtttttgtc ttgatttctc ccacaatgga agaatattag cagcagcttg   2100

tgccagccgg gatggatatc caattatttt atatgaaatt ccttctggac gtttcatgag   2160

agaattgtgt ggccacctca atatcattta tgatctttcc tggtcaaaag atgatcacta   2220

catccttact tcatcatctg atggcactgc caggatatgg aaaaatgaaa taaacaatac   2280

aaatactttc agagttttac ctcatccttc ttttgtttac acggctaaat tccatccagc   2340

tgtaagagag ctagtagtta caggatgcta tgattccatg atacggatat ggaaagttga   2400

gatgagagaa gattctgcca tattggtccg acagtttgat gttcacaaaa gttttatcaa   2460

ctcactttgt tttgatactg aaggtcatca tatgtattca ggagattgta caggggtgat   2520

tgttgtttgg aatacctatg tcaagattaa tgatttggaa cattcagtgc accactggac   2580

tataaataag gaaattaaag aaactgagtt taagggaatt ccaataagtt atttggagat   2640

tcatcccaat ggaaaacgtt tgttaatcca taccaaagac agtactttga gaattatgga   2700

tctccggata ttagtagcaa ggaagtttgt aggagcagca aattatcggg agaagattca   2760

tagtactttg actccatgtg ggacttttct gtttgctgga agtgaggatg gtatagtgta   2820

tgtttggaac ccagaaacag gagaacaagt agccatgtat tctgacttgc cattcaagtc   2880

acccattcga gacatttctt atcatccatt tgaaaatatg gttgcattct gtgcatttgg   2940

gcaaaatgag ccaattcttc tgtatattta cgatttccat gttgcccagc aggaggctga   3000

aatgttcaaa cgctacaatg gaacatttcc attacctgga atacaccaaa gtcaagatgc   3060

cctatgtacc tgtccaaaac taccccatca aggctctttt cagattgatg aatttgtcca   3120

cactgaaagt tcttcaacga agatgcagct agtaaaacag aggcttgaaa ctgtcacaga   3180

ggtgatacgt tcctgtgctg caaaagtcaa caaaaatctc tcatttactt caccaccagc   3240

agtttcctca caacagtcta agttaaagca gtcaaacatg ctgaccgctc aagagattct   3300

acatcagttt ggtttcactc agaccgggat tatcagcata gaaagaaagc cttgtaacca   3360

tcaggtagat acagcaccaa cggtagtggc tctttatgac tacacagcga atcgatcaga   3420

tgaactaacc atccatcgcg gagacattat ccgagtgttt ttcaaagata atgaagactg   3480

gtggtatggc agcataggaa agggacagga aggttatttt ccagctaatc atgtggctag   3540

tgaaacactg tatcaagaac tgcctcctga gataaaggag cgatcccctc ctttaagccc   3600

tgaggaaaaa actaaaatag aaaaatctcc agctcctcaa aagcaatcaa tcaataagaa   3660

caagtcccag gacttcagac taggctcaga atctatgaca cattctgaaa tgagaaaaga   3720

acagagccat gaggaccaag gacacataat ggatacacgg atgaggaaga acaagcaagc   3780

aggcagaaaa gtcactctaa tagagtaaag aattgaagaa aagttaagag ctgccgaaat   3840

gcacagaggt gaaaatgaca aaccaaatgg aatttctctt cagagttcag aattttcaga   3900

tactaaggag gaagaaagga tccactactt cttgttctta tgaatgactc tagaaaaatc   3960

agaatcaagt tgtgggtgga aaaatcaacg tggcctttga gttcagttgt tataaaccat   4020

tgtgactatt gttggtcaaa gtattggtac ttatattgtt agtaattgca tcataattac   4080

attaccagtg ttggaaaact aatgaagaaa acactgtaat tgctactcag caaatgtgaa   4140

taaaaggtgt ttgcgttatt aggatgtctg ttaagtaatc atttaatatt attatattgg   4200

taatggttgt atgtgtgatg ctatgcccag aatatgaagt atctgttttt gaaattcact   4260

ttatttaaaa gataagcagc tgactgggca cggtgcctca tgcctgtaat cctagcacct   4320

tgggaggctg aggcaggtgg atcacctaag gtcaggagtt caacaacacc agcctgacca   4380

acatggtgaa accccatctc tactaaaaat acaaaaatca gccgggtctc atggcaggca   4440

cctgtaatcc catctactga ggcaggagaa ttgcttgacc caggaggcag aggttgcagt   4500

gagccaagat cacgccattg cactccagcc tgggggacag agcaagactc tatctccaaa   4560

aaacaaaaaa gataagcagc tttagaatat ggcgcattca aaacagtctc agtaacaaag   4620

acattaaaag aaaacaattt actttctaat taaaattttg tgtttcttaa gatcaaatca   4680

tataggtaac ttcatagacc taaattaaaa gtgatttttg gctggactgg caacaatgtt   4740

cccaatgtct ttacttttta aaaaaggctt ttcatattta agcacatacc tattttgtag   4800

acttacattg tttaatattt attttaatct taatattttt acattattat attgcattat   4860

ttattttttc taagttccag aataatagtg tcattattat agactatatg ttttgaagtt   4920

tgatattata atgggatatt cattttttgt tcttttcttg actcctttct caagtgtgtg   4980

ataaggtctg ctgataaaat atttaacccc aagaaagtga aaactaatat aaaattagaa   5040

agacctatcc aaattagaca gtcaattcca ttaaaataag aagtgagaaa aacaatgttg   5100

ggcattgagg tgtaaatttt gcccagatgt atacccagtg tgaaatatct tctaataaaa   5160

atatatttgg ctcttatccc tgcacatgta gaggcataaa aattggtaaa catgtcccgc   5220

tgtgtagaac tttaaaaaaa aggcattttt gaaagtgttg agtggcactg ataactggtg   5280

aagcctacag ccatccgccc aaaagtctgt tctgatggca ctgagttttc attgttctgg   5340

atgtataagt ctgtgtgtca ggtacagctg ggcccagcca gcttgagtca ctcttgtaca   5400

agcttgtttt tttctgtctt gtgaatgcac ttgataattt aaaaataaaa atatctgttt   5460

ctctgcagtt tcagct                                                   5476


<210>  3379
<211>  1196
<212>  PRT
<213>  Homo sapiens

<400>  3379

Met Pro Thr Ala Glu Ser Glu Ala Lys Val Lys Thr Lys Val Arg Phe 
1               5                   10                  15


Glu Glu Leu Leu Lys Thr His Ser Asp Leu Met Arg Glu Lys Lys Lys 
            20                  25                  30


Leu Lys Lys Lys Leu Val Arg Ser Glu Glu Asn Ile Ser Pro Asp Thr 
        35                  40                  45


Ile Arg Ser Asn Leu His Tyr Met Lys Glu Thr Thr Ser Asp Asp Pro 
    50                  55                  60


Asp Thr Ile Arg Ser Asn Leu Pro His Ile Lys Glu Thr Thr Ser Asp 
65                  70                  75                  80


Asp Val Ser Ala Ala Asn Thr Asn Asn Leu Lys Lys Ser Thr Arg Val 
                85                  90                  95


Thr Lys Asn Lys Leu Arg Asn Thr Gln Leu Ala Thr Glu Asn Pro Asn 
            100                 105                 110


Gly Asp Ala Ser Val Glu Glu Asp Lys Gln Gly Lys Pro Asn Lys Lys 
        115                 120                 125


Val Ile Lys Thr Val Pro Gln Leu Thr Thr Gln Asp Leu Lys Pro Glu 
    130                 135                 140


Thr Pro Glu Asn Lys Val Asp Ser Thr His Gln Lys Thr His Thr Lys 
145                 150                 155                 160


Pro Gln Pro Gly Val Asp His Gln Lys Ser Glu Lys Ala Asn Glu Gly 
                165                 170                 175


Arg Glu Glu Thr Asp Leu Glu Glu Asp Glu Glu Leu Met Gln Ala Tyr 
            180                 185                 190


Gln Cys His Val Thr Glu Glu Met Ala Lys Glu Ile Lys Arg Lys Ile 
        195                 200                 205


Arg Lys Lys Leu Lys Glu Gln Leu Thr Tyr Phe Pro Ser Asp Thr Leu 
    210                 215                 220


Phe His Asp Asp Lys Leu Ser Ser Glu Lys Arg Lys Lys Lys Lys Glu 
225                 230                 235                 240


Val Pro Val Phe Ser Lys Ala Glu Thr Ser Thr Leu Thr Ile Ser Gly 
                245                 250                 255


Asp Thr Val Glu Gly Glu Gln Lys Lys Glu Ser Ser Val Arg Ser Val 
            260                 265                 270


Ser Ser Asp Ser His Gln Asp Asp Glu Ile Ser Ser Met Glu Gln Ser 
        275                 280                 285


Thr Glu Asp Ser Met Gln Asp Asp Thr Lys Pro Lys Pro Lys Lys Thr 
    290                 295                 300


Lys Lys Lys Thr Lys Ala Val Ala Asp Asn Asn Glu Asp Val Asp Gly 
305                 310                 315                 320


Asp Gly Val His Glu Ile Thr Ser Arg Asp Ser Pro Val Tyr Pro Lys 
                325                 330                 335


Cys Leu Leu Asp Asp Asp Leu Val Leu Gly Val Tyr Ile His Arg Thr 
            340                 345                 350


Asp Arg Leu Lys Ser Asp Phe Met Ile Ser His Pro Met Val Lys Ile 
        355                 360                 365


His Val Val Asp Glu His Thr Gly Gln Tyr Val Lys Lys Asp Asp Ser 
    370                 375                 380


Gly Arg Pro Val Ser Ser Tyr Tyr Glu Lys Glu Asn Val Asp Tyr Ile 
385                 390                 395                 400


Leu Pro Ile Met Thr Gln Pro Tyr Asp Phe Lys Gln Leu Lys Ser Arg 
                405                 410                 415


Leu Pro Glu Trp Glu Glu Gln Ile Val Phe Asn Glu Asn Phe Pro Tyr 
            420                 425                 430


Leu Leu Arg Gly Ser Asp Glu Ser Pro Lys Val Ile Leu Phe Phe Glu 
        435                 440                 445


Ile Leu Asp Phe Leu Ser Val Asp Glu Ile Lys Asn Asn Ser Glu Val 
    450                 455                 460


Gln Asn Gln Glu Cys Gly Phe Arg Lys Ile Ala Trp Ala Phe Leu Lys 
465                 470                 475                 480


Leu Leu Gly Ala Asn Gly Asn Ala Asn Ile Asn Ser Lys Leu Arg Leu 
                485                 490                 495


Gln Leu Tyr Tyr Pro Pro Thr Lys Pro Arg Ser Pro Leu Ser Val Val 
            500                 505                 510


Glu Ala Phe Glu Trp Trp Ser Lys Cys Pro Arg Asn His Tyr Pro Ser 
        515                 520                 525


Thr Leu Tyr Val Thr Val Arg Gly Leu Lys Val Pro Asp Cys Ile Lys 
    530                 535                 540


Pro Ser Tyr Arg Ser Met Met Ala Leu Gln Glu Glu Lys Gly Lys Pro 
545                 550                 555                 560


Val His Cys Glu Arg His His Glu Ser Ser Ser Val Asp Thr Glu Pro 
                565                 570                 575


Gly Leu Glu Glu Ser Lys Glu Val Ile Lys Trp Lys Arg Leu Pro Gly 
            580                 585                 590


Gln Ala Cys Arg Ile Pro Asn Lys His Leu Phe Ser Leu Asn Ala Gly 
        595                 600                 605


Glu Arg Gly Cys Phe Cys Leu Asp Phe Ser His Asn Gly Arg Ile Leu 
    610                 615                 620


Ala Ala Ala Cys Ala Ser Arg Asp Gly Tyr Pro Ile Ile Leu Tyr Glu 
625                 630                 635                 640


Ile Pro Ser Gly Arg Phe Met Arg Glu Leu Cys Gly His Leu Asn Ile 
                645                 650                 655


Ile Tyr Asp Leu Ser Trp Ser Lys Asp Asp His Tyr Ile Leu Thr Ser 
            660                 665                 670


Ser Ser Asp Gly Thr Ala Arg Ile Trp Lys Asn Glu Ile Asn Asn Thr 
        675                 680                 685


Asn Thr Phe Arg Val Leu Pro His Pro Ser Phe Val Tyr Thr Ala Lys 
    690                 695                 700


Phe His Pro Ala Val Arg Glu Leu Val Val Thr Gly Cys Tyr Asp Ser 
705                 710                 715                 720


Met Ile Arg Ile Trp Lys Val Glu Met Arg Glu Asp Ser Ala Ile Leu 
                725                 730                 735


Val Arg Gln Phe Asp Val His Lys Ser Phe Ile Asn Ser Leu Cys Phe 
            740                 745                 750


Asp Thr Glu Gly His His Met Tyr Ser Gly Asp Cys Thr Gly Val Ile 
        755                 760                 765


Val Val Trp Asn Thr Tyr Val Lys Ile Asn Asp Leu Glu His Ser Val 
    770                 775                 780


His His Trp Thr Ile Asn Lys Glu Ile Lys Glu Thr Glu Phe Lys Gly 
785                 790                 795                 800


Ile Pro Ile Ser Tyr Leu Glu Ile His Pro Asn Gly Lys Arg Leu Leu 
                805                 810                 815


Ile His Thr Lys Asp Ser Thr Leu Arg Ile Met Asp Leu Arg Ile Leu 
            820                 825                 830


Val Ala Arg Lys Phe Val Gly Ala Ala Asn Tyr Arg Glu Lys Ile His 
        835                 840                 845


Ser Thr Leu Thr Pro Cys Gly Thr Phe Leu Phe Ala Gly Ser Glu Asp 
    850                 855                 860


Gly Ile Val Tyr Val Trp Asn Pro Glu Thr Gly Glu Gln Val Ala Met 
865                 870                 875                 880


Tyr Ser Asp Leu Pro Phe Lys Ser Pro Ile Arg Asp Ile Ser Tyr His 
                885                 890                 895


Pro Phe Glu Asn Met Val Ala Phe Cys Ala Phe Gly Gln Asn Glu Pro 
            900                 905                 910


Ile Leu Leu Tyr Ile Tyr Asp Phe His Val Ala Gln Gln Glu Ala Glu 
        915                 920                 925


Met Phe Lys Arg Tyr Asn Gly Thr Phe Pro Leu Pro Gly Ile His Gln 
    930                 935                 940


Ser Gln Asp Ala Leu Cys Thr Cys Pro Lys Leu Pro His Gln Gly Ser 
945                 950                 955                 960


Phe Gln Ile Asp Glu Phe Val His Thr Glu Ser Ser Ser Thr Lys Met 
                965                 970                 975


Gln Leu Val Lys Gln Arg Leu Glu Thr Val Thr Glu Val Ile Arg Ser 
            980                 985                 990


Cys Ala Ala Lys Val Asn Lys Asn Leu Ser Phe Thr Ser Pro Pro Ala 
        995                 1000                1005


Val Ser Ser Gln Gln Ser Lys Leu Lys Gln Ser Asn Met Leu Thr Ala 
    1010                1015                1020


Gln Glu Ile Leu His Gln Phe Gly Phe Thr Gln Thr Gly Ile Ile Ser 
1025                1030                1035                1040


Ile Glu Arg Lys Pro Cys Asn His Gln Val Asp Thr Ala Pro Thr Val 
                1045                1050                1055


Val Ala Leu Tyr Asp Tyr Thr Ala Asn Arg Ser Asp Glu Leu Thr Ile 
            1060                1065                1070


His Arg Gly Asp Ile Ile Arg Val Phe Phe Lys Asp Asn Glu Asp Trp 
        1075                1080                1085


Trp Tyr Gly Ser Ile Gly Lys Gly Gln Glu Gly Tyr Phe Pro Ala Asn 
    1090                1095                1100


His Val Ala Ser Glu Thr Leu Tyr Gln Glu Leu Pro Pro Glu Ile Lys 
1105                1110                1115                1120


Glu Arg Ser Pro Pro Leu Ser Pro Glu Glu Lys Thr Lys Ile Glu Lys 
                1125                1130                1135


Ser Pro Ala Pro Gln Lys Gln Ser Ile Asn Lys Asn Lys Ser Gln Asp 
            1140                1145                1150


Phe Arg Leu Gly Ser Glu Ser Met Thr His Ser Glu Met Arg Lys Glu 
        1155                1160                1165


Gln Ser His Glu Asp Gln Gly His Ile Met Asp Thr Arg Met Arg Lys 
    1170                1175                1180


Asn Lys Gln Ala Gly Arg Lys Val Thr Leu Ile Glu 
1185                1190                1195


<210>  3380
<211>  5558
<212>  DNA
<213>  Homo sapiens

<400>  3380
ggcggcgcgc tgtccgcact gcggcacaga gccgcggctt gctttcagga cacgggtcgc     60

tggcgggtta ggtggctgcg tggccgcctc acttcgcgca cgcgccgcta ggctggggga    120

gttgatttgc actgctccgg gtgtcggctc cggcgggacg ggcggttctg cgtacccctc    180

tccagtgtca acctggggct gaatcttcaa cctgtcaaag ccttcttaat tatgtctgag    240

aaaaggatcc tgattgagtc aatgctttgc attctcagtc ctctgcataa agctgagaga    300

tgcctacagc tgagagtgaa gcaaaagtaa aaaccaaagt tcgctttgaa gaattgctta    360

agacccacag tgatctaatg cgtgaaaaga aaaaactgaa gaaaaaactt gtcaggtctg    420

aagaaaacat ctcacctgac actattagaa gcaatcttca ctatatgaaa gaaactacaa    480

gtgatgatcc cgacactatt agaagcaatc ttccccatat taaagaaact acaagtgatg    540

atgtaagtgc tgctaacact aacaacctga agaagagcac gagagtcact aaaaacaaat    600

tgaggaacac acagttagca actgaaaatc ctaatggtga tgctagtgta gaggaagaca    660

aacaaggaaa gccaaataaa aaggtgataa agacggtgcc ccagttgact acacaagacc    720

tgaaaccgga aactcctgag aataaggttg attctacaca ccagaaaaca catacaaagc    780

cacagccagg cgttgatcat cagaaaagtg agaaggcaaa tgagggaaga gaagagactg    840

atttagaaga ggatgaagaa ttgatgcaag catatcagtg ccatgtaact gaagaaatgg    900

caaaggagat taagaggaaa ataagaaaga aactgaaaga acagttgact tactttccct    960

cagatacttt attccatgat gacaaactaa gcagtgaaaa aaggaaaaag aaaaaggaag   1020

ttccagtctt ctctaaagct gaaacaagta cattgaccat ctctggtgac acagttgaag   1080

gtgaacaaaa gaaagaatct tcagttagat cagtttcttc agattctcat caagatgatg   1140

aaataagctc aatggaacaa agcacagaag acagcatgca agatgataca aaacctaaac   1200

caaaaaaaac aaaaaagaag actaaagcag ttgcagataa taatgaagat gttgatggtg   1260

atggtgttca tgaaataaca agccgagata gcccggttta tcccaaatgt ttgcttgatg   1320

atgaccttgt cttgggagtt tacattcacc gaactgatag acttaagtca gattttatga   1380

tttctcaccc aatggtaaaa attcatgtgg ttgatgagca tactggtcaa tatgtcaaga   1440

aagatgatag tggacggcct gtttcatctt actatgaaaa agagaatgtg gattatattc   1500

ttcctattat gacccagcca tatgatttta aacagttaaa atcaagactt ccagagtggg   1560

aagaacaaat tgtatttaat gaaaattttc cctatttgct tcgaggctct gatgagagtc   1620

ctaaagtcat cctgttcttt gagattcttg atttcttaag cgtggatgaa attaagaata   1680

attctgaggt tcaaaaccaa gaatgtggct ttcggaaaat tgcctgggca tttcttaagc   1740

ttctgggagc caatggaaat gcaaacatca actcaaaact tcgcttgcag ctatattacc   1800

cacctactaa gcctcgatcc ccattaagtg ttgttgaggc atttgaatgg tggtcaaaat   1860

gtccaagaaa tcattaccca tcaacactgt acgtaactgt aagaggactg aaagttccag   1920

actgtataaa gccatcttac cgctctatga tggctcttca ggaggaaaaa ggtaaaccag   1980

tgcattgtga acgtcaccat gagtcaagct cagtagacac agaacctgga ttagaagagt   2040

caaaggaagt aataaagtgg aaacgactcc ctgggcaggc ttgccgtatc ccaaacaaac   2100

acctcttctc actaaatgca ggagaacgag gatgtttttg tcttgatttc tcccacaatg   2160

gaagaatatt agcagcagct tgtgccagcc gggatggata tccaattatt ttatatgaaa   2220

ttccttctgg acgtttcatg agagaattgt gtggccacct caatatcatt tatgatcttt   2280

cctggtcaaa agatgatcac tacatcctta cttcatcatc tgatggcact gccaggatat   2340

ggaaaaatga aataaacaat acaaatactt tcagagtttt acctcatcct tcttttgttt   2400

acacggctaa attccatcca gctgtaagag agctagtagt tacaggatgc tatgattcca   2460

tgatacggat atggaaagtt gagatgagag aagattctgc catattggtc cgacagtttg   2520

atgttcacaa aagttttatc aactcacttt gttttgatac tgaaggtcat catatgtatt   2580

caggagattg tacaggggtg attgttgttt ggaataccta tgtcaagatt aatgatttgg   2640

aacattcagt gcaccactgg actataaata aggaaattaa agaaactgag tttaagggaa   2700

ttccaataag ttatttggag attcatccca atggaaaacg tttgttaatc cataccaaag   2760

acagtacttt gagaattatg gatctccgga tattagtagc aaggaagttt gtaggagcag   2820

caaattatcg ggagaagatt catagtactt tgactccatg tgggactttt ctgtttgctg   2880

gaagtgagga tggtatagtg tatgtttgga acccagaaac aggagaacaa gtagccatgt   2940

attctgactt gccattcaag tcacccattc gagacatttc ttatcatcca tttgaaaata   3000

tggttgcatt ctgtgcattt gggcaaaatg agccaattct tctgtatatt tacgatttcc   3060

atgttgccca gcaggaggct gaaatgttca aacgctacaa tggaacattt ccattacctg   3120

gaatacacca aagtcaagat gccctatgta cctgtccaaa actaccccat caaggctctt   3180

ttcagattga tgaatttgtc cacactgaaa gttcttcaac gaagatgcag ctagtaaaac   3240

agaggcttga aactgtcaca gaggtgatac gttcctgtgc tgcaaaagtc aacaaaaatc   3300

tctcatttac ttcaccacca gcagtttcct cacaacagtc taagttaaag cagtcaaaca   3360

tgctgaccgc tcaagagatt ctacatcagt ttggtttcac tcagaccggg attatcagca   3420

tagaaagaaa gccttgtaac catcaggtag atacagcacc aacggtagtg gctctttatg   3480

actacacagc gaatcgatca gatgaactaa ccatccatcg cggagacatt atccgagtgt   3540

ttttcaaaga taatgaagac tggtggtatg gcagcatagg aaagggacag gaaggttatt   3600

ttccagctaa tcatgtggct agtgaaacac tgtatcaaga actgcctcct gagataaagg   3660

agcgatcccc tcctttaagc cctgaggaaa aaactaaaat agaaaaatct ccagctcctc   3720

aaaagcaatc aatcaataag aacaagtccc aggacttcag actaggctca gaatctatga   3780

cacattctga aatgagaaaa gaacagagcc atgaggacca aggacacata atggatacac   3840

ggatgaggaa gaacaagcaa gcaggcagaa aagtcactct aatagagtaa agaattgaag   3900

aaaagttaag agctgccgaa atgcacagag gtgaaaatga caaaccaaat ggaatttctc   3960

ttcagagttc agaattttca gatactaagg aggaagaaag gatccactac ttcttgttct   4020

tatgaatgac tctagaaaaa tcagaatcaa gttgtgggtg gaaaaatcaa cgtggccttt   4080

gagttcagtt gttataaacc attgtgacta ttgttggtca aagtattggt acttatattg   4140

ttagtaattg catcataatt acattaccag tgttggaaaa ctaatgaaga aaacactgta   4200

attgctactc agcaaatgtg aataaaaggt gtttgcgtta ttaggatgtc tgttaagtaa   4260

tcatttaata ttattatatt ggtaatggtt gtatgtgtga tgctatgccc agaatatgaa   4320

gtatctgttt ttgaaattca ctttatttaa aagataagca gctgactggg cacggtgcct   4380

catgcctgta atcctagcac cttgggaggc tgaggcaggt ggatcaccta aggtcaggag   4440

ttcaacaaca ccagcctgac caacatggtg aaaccccatc tctactaaaa atacaaaaat   4500

cagccgggtc tcatggcagg cacctgtaat cccatctact gaggcaggag aattgcttga   4560

cccaggaggc agaggttgca gtgagccaag atcacgccat tgcactccag cctgggggac   4620

agagcaagac tctatctcca aaaaacaaaa aagataagca gctttagaat atggcgcatt   4680

caaaacagtc tcagtaacaa agacattaaa agaaaacaat ttactttcta attaaaattt   4740

tgtgtttctt aagatcaaat catataggta acttcataga cctaaattaa aagtgatttt   4800

tggctggact ggcaacaatg ttcccaatgt ctttactttt taaaaaaggc ttttcatatt   4860

taagcacata cctattttgt agacttacat tgtttaatat ttattttaat cttaatattt   4920

ttacattatt atattgcatt atttattttt tctaagttcc agaataatag tgtcattatt   4980

atagactata tgttttgaag tttgatatta taatgggata ttcatttttt gttcttttct   5040

tgactccttt ctcaagtgtg tgataaggtc tgctgataaa atatttaacc ccaagaaagt   5100

gaaaactaat ataaaattag aaagacctat ccaaattaga cagtcaattc cattaaaata   5160

agaagtgaga aaaacaatgt tgggcattga ggtgtaaatt ttgcccagat gtatacccag   5220

tgtgaaatat cttctaataa aaatatattt ggctcttatc cctgcacatg tagaggcata   5280

aaaattggta aacatgtccc gctgtgtaga actttaaaaa aaaggcattt ttgaaagtgt   5340

tgagtggcac tgataactgg tgaagcctac agccatccgc ccaaaagtct gttctgatgg   5400

cactgagttt tcattgttct ggatgtataa gtctgtgtgt caggtacagc tgggcccagc   5460

cagcttgagt cactcttgta caagcttgtt tttttctgtc ttgtgaatgc acttgataat   5520

ttaaaaataa aaatatctgt ttctctgcag tttcagct                           5558


<210>  3381
<211>  1196
<212>  PRT
<213>  Homo sapiens

<400>  3381

Met Pro Thr Ala Glu Ser Glu Ala Lys Val Lys Thr Lys Val Arg Phe 
1               5                   10                  15


Glu Glu Leu Leu Lys Thr His Ser Asp Leu Met Arg Glu Lys Lys Lys 
            20                  25                  30


Leu Lys Lys Lys Leu Val Arg Ser Glu Glu Asn Ile Ser Pro Asp Thr 
        35                  40                  45


Ile Arg Ser Asn Leu His Tyr Met Lys Glu Thr Thr Ser Asp Asp Pro 
    50                  55                  60


Asp Thr Ile Arg Ser Asn Leu Pro His Ile Lys Glu Thr Thr Ser Asp 
65                  70                  75                  80


Asp Val Ser Ala Ala Asn Thr Asn Asn Leu Lys Lys Ser Thr Arg Val 
                85                  90                  95


Thr Lys Asn Lys Leu Arg Asn Thr Gln Leu Ala Thr Glu Asn Pro Asn 
            100                 105                 110


Gly Asp Ala Ser Val Glu Glu Asp Lys Gln Gly Lys Pro Asn Lys Lys 
        115                 120                 125


Val Ile Lys Thr Val Pro Gln Leu Thr Thr Gln Asp Leu Lys Pro Glu 
    130                 135                 140


Thr Pro Glu Asn Lys Val Asp Ser Thr His Gln Lys Thr His Thr Lys 
145                 150                 155                 160


Pro Gln Pro Gly Val Asp His Gln Lys Ser Glu Lys Ala Asn Glu Gly 
                165                 170                 175


Arg Glu Glu Thr Asp Leu Glu Glu Asp Glu Glu Leu Met Gln Ala Tyr 
            180                 185                 190


Gln Cys His Val Thr Glu Glu Met Ala Lys Glu Ile Lys Arg Lys Ile 
        195                 200                 205


Arg Lys Lys Leu Lys Glu Gln Leu Thr Tyr Phe Pro Ser Asp Thr Leu 
    210                 215                 220


Phe His Asp Asp Lys Leu Ser Ser Glu Lys Arg Lys Lys Lys Lys Glu 
225                 230                 235                 240


Val Pro Val Phe Ser Lys Ala Glu Thr Ser Thr Leu Thr Ile Ser Gly 
                245                 250                 255


Asp Thr Val Glu Gly Glu Gln Lys Lys Glu Ser Ser Val Arg Ser Val 
            260                 265                 270


Ser Ser Asp Ser His Gln Asp Asp Glu Ile Ser Ser Met Glu Gln Ser 
        275                 280                 285


Thr Glu Asp Ser Met Gln Asp Asp Thr Lys Pro Lys Pro Lys Lys Thr 
    290                 295                 300


Lys Lys Lys Thr Lys Ala Val Ala Asp Asn Asn Glu Asp Val Asp Gly 
305                 310                 315                 320


Asp Gly Val His Glu Ile Thr Ser Arg Asp Ser Pro Val Tyr Pro Lys 
                325                 330                 335


Cys Leu Leu Asp Asp Asp Leu Val Leu Gly Val Tyr Ile His Arg Thr 
            340                 345                 350


Asp Arg Leu Lys Ser Asp Phe Met Ile Ser His Pro Met Val Lys Ile 
        355                 360                 365


His Val Val Asp Glu His Thr Gly Gln Tyr Val Lys Lys Asp Asp Ser 
    370                 375                 380


Gly Arg Pro Val Ser Ser Tyr Tyr Glu Lys Glu Asn Val Asp Tyr Ile 
385                 390                 395                 400


Leu Pro Ile Met Thr Gln Pro Tyr Asp Phe Lys Gln Leu Lys Ser Arg 
                405                 410                 415


Leu Pro Glu Trp Glu Glu Gln Ile Val Phe Asn Glu Asn Phe Pro Tyr 
            420                 425                 430


Leu Leu Arg Gly Ser Asp Glu Ser Pro Lys Val Ile Leu Phe Phe Glu 
        435                 440                 445


Ile Leu Asp Phe Leu Ser Val Asp Glu Ile Lys Asn Asn Ser Glu Val 
    450                 455                 460


Gln Asn Gln Glu Cys Gly Phe Arg Lys Ile Ala Trp Ala Phe Leu Lys 
465                 470                 475                 480


Leu Leu Gly Ala Asn Gly Asn Ala Asn Ile Asn Ser Lys Leu Arg Leu 
                485                 490                 495


Gln Leu Tyr Tyr Pro Pro Thr Lys Pro Arg Ser Pro Leu Ser Val Val 
            500                 505                 510


Glu Ala Phe Glu Trp Trp Ser Lys Cys Pro Arg Asn His Tyr Pro Ser 
        515                 520                 525


Thr Leu Tyr Val Thr Val Arg Gly Leu Lys Val Pro Asp Cys Ile Lys 
    530                 535                 540


Pro Ser Tyr Arg Ser Met Met Ala Leu Gln Glu Glu Lys Gly Lys Pro 
545                 550                 555                 560


Val His Cys Glu Arg His His Glu Ser Ser Ser Val Asp Thr Glu Pro 
                565                 570                 575


Gly Leu Glu Glu Ser Lys Glu Val Ile Lys Trp Lys Arg Leu Pro Gly 
            580                 585                 590


Gln Ala Cys Arg Ile Pro Asn Lys His Leu Phe Ser Leu Asn Ala Gly 
        595                 600                 605


Glu Arg Gly Cys Phe Cys Leu Asp Phe Ser His Asn Gly Arg Ile Leu 
    610                 615                 620


Ala Ala Ala Cys Ala Ser Arg Asp Gly Tyr Pro Ile Ile Leu Tyr Glu 
625                 630                 635                 640


Ile Pro Ser Gly Arg Phe Met Arg Glu Leu Cys Gly His Leu Asn Ile 
                645                 650                 655


Ile Tyr Asp Leu Ser Trp Ser Lys Asp Asp His Tyr Ile Leu Thr Ser 
            660                 665                 670


Ser Ser Asp Gly Thr Ala Arg Ile Trp Lys Asn Glu Ile Asn Asn Thr 
        675                 680                 685


Asn Thr Phe Arg Val Leu Pro His Pro Ser Phe Val Tyr Thr Ala Lys 
    690                 695                 700


Phe His Pro Ala Val Arg Glu Leu Val Val Thr Gly Cys Tyr Asp Ser 
705                 710                 715                 720


Met Ile Arg Ile Trp Lys Val Glu Met Arg Glu Asp Ser Ala Ile Leu 
                725                 730                 735


Val Arg Gln Phe Asp Val His Lys Ser Phe Ile Asn Ser Leu Cys Phe 
            740                 745                 750


Asp Thr Glu Gly His His Met Tyr Ser Gly Asp Cys Thr Gly Val Ile 
        755                 760                 765


Val Val Trp Asn Thr Tyr Val Lys Ile Asn Asp Leu Glu His Ser Val 
    770                 775                 780


His His Trp Thr Ile Asn Lys Glu Ile Lys Glu Thr Glu Phe Lys Gly 
785                 790                 795                 800


Ile Pro Ile Ser Tyr Leu Glu Ile His Pro Asn Gly Lys Arg Leu Leu 
                805                 810                 815


Ile His Thr Lys Asp Ser Thr Leu Arg Ile Met Asp Leu Arg Ile Leu 
            820                 825                 830


Val Ala Arg Lys Phe Val Gly Ala Ala Asn Tyr Arg Glu Lys Ile His 
        835                 840                 845


Ser Thr Leu Thr Pro Cys Gly Thr Phe Leu Phe Ala Gly Ser Glu Asp 
    850                 855                 860


Gly Ile Val Tyr Val Trp Asn Pro Glu Thr Gly Glu Gln Val Ala Met 
865                 870                 875                 880


Tyr Ser Asp Leu Pro Phe Lys Ser Pro Ile Arg Asp Ile Ser Tyr His 
                885                 890                 895


Pro Phe Glu Asn Met Val Ala Phe Cys Ala Phe Gly Gln Asn Glu Pro 
            900                 905                 910


Ile Leu Leu Tyr Ile Tyr Asp Phe His Val Ala Gln Gln Glu Ala Glu 
        915                 920                 925


Met Phe Lys Arg Tyr Asn Gly Thr Phe Pro Leu Pro Gly Ile His Gln 
    930                 935                 940


Ser Gln Asp Ala Leu Cys Thr Cys Pro Lys Leu Pro His Gln Gly Ser 
945                 950                 955                 960


Phe Gln Ile Asp Glu Phe Val His Thr Glu Ser Ser Ser Thr Lys Met 
                965                 970                 975


Gln Leu Val Lys Gln Arg Leu Glu Thr Val Thr Glu Val Ile Arg Ser 
            980                 985                 990


Cys Ala Ala Lys Val Asn Lys Asn Leu Ser Phe Thr Ser Pro Pro Ala 
        995                 1000                1005


Val Ser Ser Gln Gln Ser Lys Leu Lys Gln Ser Asn Met Leu Thr Ala 
    1010                1015                1020


Gln Glu Ile Leu His Gln Phe Gly Phe Thr Gln Thr Gly Ile Ile Ser 
1025                1030                1035                1040


Ile Glu Arg Lys Pro Cys Asn His Gln Val Asp Thr Ala Pro Thr Val 
                1045                1050                1055


Val Ala Leu Tyr Asp Tyr Thr Ala Asn Arg Ser Asp Glu Leu Thr Ile 
            1060                1065                1070


His Arg Gly Asp Ile Ile Arg Val Phe Phe Lys Asp Asn Glu Asp Trp 
        1075                1080                1085


Trp Tyr Gly Ser Ile Gly Lys Gly Gln Glu Gly Tyr Phe Pro Ala Asn 
    1090                1095                1100


His Val Ala Ser Glu Thr Leu Tyr Gln Glu Leu Pro Pro Glu Ile Lys 
1105                1110                1115                1120


Glu Arg Ser Pro Pro Leu Ser Pro Glu Glu Lys Thr Lys Ile Glu Lys 
                1125                1130                1135


Ser Pro Ala Pro Gln Lys Gln Ser Ile Asn Lys Asn Lys Ser Gln Asp 
            1140                1145                1150


Phe Arg Leu Gly Ser Glu Ser Met Thr His Ser Glu Met Arg Lys Glu 
        1155                1160                1165


Gln Ser His Glu Asp Gln Gly His Ile Met Asp Thr Arg Met Arg Lys 
    1170                1175                1180


Asn Lys Gln Ala Gly Arg Lys Val Thr Leu Ile Glu 
1185                1190                1195


<210>  3382
<211>  3657
<212>  DNA
<213>  Homo sapiens

<400>  3382
ggcggcgcgc tgtccgcact gcggcacaga gccgcggctt gctttcagga cacgggtcgc     60

tggcgggtta ggtggctgcg tggccgcctc acttcgcgca cgcgccgcta ggctggggga    120

gttgatttgc actgctccgg gtgtcggctc cggcgggacg ggcggttctg cgtacccctc    180

tccagtgtca acctggggct gaatcttcaa cctgtcaaag ccttcttaat tatgtctgag    240

aaaaggatcc tgattgagtc aatgctttgc attctcagtc ctctgcataa agctgagaga    300

tgcctacagc tgagagtgaa gcaaaagtaa aaaccaaagt tcgctttgaa gaattgctta    360

agacccacag tgatctaatg cgtgaaaaga aaaaactgaa gaaaaaactt gtcaggtctg    420

aagaaaacat ctcacctgac actattagaa gcaatcttca ctatatgaaa gaaactacaa    480

gtgatgatcc cgacactatt agaagcaatc ttccccatat taaagaaact acaagtgatg    540

atgtaagtgc tgctaacact aacaacctga agaagagcac gagagtcact aaaaacaaat    600

tgaggaacac acagttagca actgaaaatc ctaatggtga tgctagtgta gaggaagaca    660

aacaaggaaa gccaaataaa aaggtgataa agacggtgcc ccagttgact acacaagacc    720

tgaaaccgga aactcctgag aataaggttg attctacaca ccagaaaaca catacaaagc    780

cacagccagg cgttgatcat cagaaaagtg agaaggcaaa tgagggaaga gaagagactg    840

atttagaaga ggatgaagaa ttgatgcaag catatcagtg ccatgtaact gaagaaatgg    900

caaaggagat taagaggaaa ataagaaaga aactgaaaga acagttgact tactttccct    960

cagatacttt attccatgat gacaaactaa gcagtgaaaa aaggaaaaag aaaaaggaag   1020

ttccagtctt ctctaaagct gaaacaagta cattgaccat ctctggtgac acagttgaag   1080

gtgaacaaaa gaaagaatct tcagttagat cagtttcttc agattctcat caagatgatg   1140

aaataagctc aatggaacaa agcacagaag acagcatgca agatgataca aaacctaaac   1200

caaaaaaaac aaaaaagaag actaaagcag ttgcagataa taatgaagat gttgatggtg   1260

atggtgttca tgaaataaca agccgagata gcccggttta tcccaaatgt ttgcttgatg   1320

atgaccttgt cttgggagtt tacattcacc gaactgatag acttaagtca gattttatga   1380

tttctcaccc aatggtaaaa attcatgtgg ttgatgagca tactggtcaa tatgtcaaga   1440

aagatgatag tggacggcct gtttcatctt actatgaaaa agagaatgtg gattatattc   1500

ttcctattat gacccagcca tatgatttta aacagttaaa atcaagactt ccagagtggg   1560

aagaacaaat tgtatttaat gaaaattttc cctatttgct tcgaggctct gatgagagtc   1620

ctaaagtcat cctgttcttt gagattcttg atttcttaag cgtggatgaa attaagaata   1680

attctgaggt tcaaaaccaa gaatgtggct ttcggaaaat tgcctgggca tttcttaagc   1740

ttctgggagc caatggaaat gcaaacatca actcaaaact tcgcttgcag ctatattacc   1800

cacctactaa gcctcgatcc ccattaagtg ttgttgaggc atttgaatgg tggtcaaaat   1860

gtccaagaaa tcattaccca tcaacactgt acgtaactgt aagaggactg aaagttccag   1920

actgtataaa gccatcttac cgctctatga tggctcttca ggaggaaaaa ggtaaaccag   1980

tgcattgtga acgtcaccat gagtcaagct cagtagacac agaacctgga ttagaagagt   2040

caaaggaagt aataaagtgg aaacgactcc ctgggcaggc ttgccgtatc ccaaacaaac   2100

acctcttctc actaaatgca ggagaacgag gatgtttttg tcttgatttc tcccacaatg   2160

gaagaatatt agcagcagct tgtgccagcc gggatggata tccaattatt ttatatgaaa   2220

ttccttctgg acgtttcatg agagaattgt gtggccacct caatatcatt tatgatcttt   2280

cctggtcaaa agatgatcac tacatcctta cttcatcatc tgatggcact gccaggatat   2340

ggaaaaatga aataaacaat acaaatactt tcagagtttt acctcatcct tcttttgttt   2400

acacggctaa attccatcca gctgtaagag agctagtagt tacaggatgc tatgattcca   2460

tgatacggat atggaaagtt gagatgagag aagattctgc catattggtc cgacagtttg   2520

atgttcacaa aagttttatc aactcacttt gttttgatac tgaaggtcat catatgtatt   2580

caggagattg tacaggggtg attgttgttt ggaataccta tgtcaagatt aatgatttgg   2640

aacattcagt gcaccactgg actataaata aggaaattaa agaaactgag tttaagggaa   2700

ttccaataag ttatttggag attcatccca atggaaaacg tttgttaatc cataccaaag   2760

acagtacttt gagaattatg gatctccgga tattagtagc aaggaagttt gtaggagcag   2820

caaattatcg ggagaagatt catagtactt tgactccatg tgggactttt ctgtttgctg   2880

gaagtgagga tggtatagtg tatgtttgga acccagaaac aggagaacaa gtagccatgt   2940

attctgactt gccattcaag tcacccattc gagacatttc ttatcatcca tttgaaaata   3000

tggttgcatt ctgtgcattt gggcaaaatg agccaattct tctgtatatt tacgatttcc   3060

atgttgccca gcaggaggct gaaatgttca aacgctacaa tggaacattt ccattacctg   3120

gaatacacca aagtcaagat gccctatgta cctgtccaaa actaccccat caaggctctt   3180

ttcagattga tgaatttgtc cacactgaaa gttcttcaac gaagatgcag ctagtaaaac   3240

agaggcttga aactgtcaca gaggtgatac gttcctgtgc tgcaaaagtc aacaaaaatc   3300

tctcatttac ttcaccacca gcagtttcct cacaacagtc taagttaaag cagtcaaaca   3360

tgctgaccgc tcaagagatt ctacatcagt ttggtttcac tcagaccgac agtcactttg   3420

ctgaattcaa cacatgtata ttatggtgga aaaagcacta gactcagggt cagccagcca   3480

gaagaactga gccgacctgg gatcccacca cttcctaact gttttgttag gtagttcact   3540

ttctctcttc ggataaatgt ctccacattt cctacttcat agaattgtca gaatcaacac   3600

aatacattta atactttgaa actcataaaa tattgggaga ataaacagta tgaggtt      3657


<210>  3383
<211>  1053
<212>  PRT
<213>  Homo sapiens

<400>  3383

Met Pro Thr Ala Glu Ser Glu Ala Lys Val Lys Thr Lys Val Arg Phe 
1               5                   10                  15


Glu Glu Leu Leu Lys Thr His Ser Asp Leu Met Arg Glu Lys Lys Lys 
            20                  25                  30


Leu Lys Lys Lys Leu Val Arg Ser Glu Glu Asn Ile Ser Pro Asp Thr 
        35                  40                  45


Ile Arg Ser Asn Leu His Tyr Met Lys Glu Thr Thr Ser Asp Asp Pro 
    50                  55                  60


Asp Thr Ile Arg Ser Asn Leu Pro His Ile Lys Glu Thr Thr Ser Asp 
65                  70                  75                  80


Asp Val Ser Ala Ala Asn Thr Asn Asn Leu Lys Lys Ser Thr Arg Val 
                85                  90                  95


Thr Lys Asn Lys Leu Arg Asn Thr Gln Leu Ala Thr Glu Asn Pro Asn 
            100                 105                 110


Gly Asp Ala Ser Val Glu Glu Asp Lys Gln Gly Lys Pro Asn Lys Lys 
        115                 120                 125


Val Ile Lys Thr Val Pro Gln Leu Thr Thr Gln Asp Leu Lys Pro Glu 
    130                 135                 140


Thr Pro Glu Asn Lys Val Asp Ser Thr His Gln Lys Thr His Thr Lys 
145                 150                 155                 160


Pro Gln Pro Gly Val Asp His Gln Lys Ser Glu Lys Ala Asn Glu Gly 
                165                 170                 175


Arg Glu Glu Thr Asp Leu Glu Glu Asp Glu Glu Leu Met Gln Ala Tyr 
            180                 185                 190


Gln Cys His Val Thr Glu Glu Met Ala Lys Glu Ile Lys Arg Lys Ile 
        195                 200                 205


Arg Lys Lys Leu Lys Glu Gln Leu Thr Tyr Phe Pro Ser Asp Thr Leu 
    210                 215                 220


Phe His Asp Asp Lys Leu Ser Ser Glu Lys Arg Lys Lys Lys Lys Glu 
225                 230                 235                 240


Val Pro Val Phe Ser Lys Ala Glu Thr Ser Thr Leu Thr Ile Ser Gly 
                245                 250                 255


Asp Thr Val Glu Gly Glu Gln Lys Lys Glu Ser Ser Val Arg Ser Val 
            260                 265                 270


Ser Ser Asp Ser His Gln Asp Asp Glu Ile Ser Ser Met Glu Gln Ser 
        275                 280                 285


Thr Glu Asp Ser Met Gln Asp Asp Thr Lys Pro Lys Pro Lys Lys Thr 
    290                 295                 300


Lys Lys Lys Thr Lys Ala Val Ala Asp Asn Asn Glu Asp Val Asp Gly 
305                 310                 315                 320


Asp Gly Val His Glu Ile Thr Ser Arg Asp Ser Pro Val Tyr Pro Lys 
                325                 330                 335


Cys Leu Leu Asp Asp Asp Leu Val Leu Gly Val Tyr Ile His Arg Thr 
            340                 345                 350


Asp Arg Leu Lys Ser Asp Phe Met Ile Ser His Pro Met Val Lys Ile 
        355                 360                 365


His Val Val Asp Glu His Thr Gly Gln Tyr Val Lys Lys Asp Asp Ser 
    370                 375                 380


Gly Arg Pro Val Ser Ser Tyr Tyr Glu Lys Glu Asn Val Asp Tyr Ile 
385                 390                 395                 400


Leu Pro Ile Met Thr Gln Pro Tyr Asp Phe Lys Gln Leu Lys Ser Arg 
                405                 410                 415


Leu Pro Glu Trp Glu Glu Gln Ile Val Phe Asn Glu Asn Phe Pro Tyr 
            420                 425                 430


Leu Leu Arg Gly Ser Asp Glu Ser Pro Lys Val Ile Leu Phe Phe Glu 
        435                 440                 445


Ile Leu Asp Phe Leu Ser Val Asp Glu Ile Lys Asn Asn Ser Glu Val 
    450                 455                 460


Gln Asn Gln Glu Cys Gly Phe Arg Lys Ile Ala Trp Ala Phe Leu Lys 
465                 470                 475                 480


Leu Leu Gly Ala Asn Gly Asn Ala Asn Ile Asn Ser Lys Leu Arg Leu 
                485                 490                 495


Gln Leu Tyr Tyr Pro Pro Thr Lys Pro Arg Ser Pro Leu Ser Val Val 
            500                 505                 510


Glu Ala Phe Glu Trp Trp Ser Lys Cys Pro Arg Asn His Tyr Pro Ser 
        515                 520                 525


Thr Leu Tyr Val Thr Val Arg Gly Leu Lys Val Pro Asp Cys Ile Lys 
    530                 535                 540


Pro Ser Tyr Arg Ser Met Met Ala Leu Gln Glu Glu Lys Gly Lys Pro 
545                 550                 555                 560


Val His Cys Glu Arg His His Glu Ser Ser Ser Val Asp Thr Glu Pro 
                565                 570                 575


Gly Leu Glu Glu Ser Lys Glu Val Ile Lys Trp Lys Arg Leu Pro Gly 
            580                 585                 590


Gln Ala Cys Arg Ile Pro Asn Lys His Leu Phe Ser Leu Asn Ala Gly 
        595                 600                 605


Glu Arg Gly Cys Phe Cys Leu Asp Phe Ser His Asn Gly Arg Ile Leu 
    610                 615                 620


Ala Ala Ala Cys Ala Ser Arg Asp Gly Tyr Pro Ile Ile Leu Tyr Glu 
625                 630                 635                 640


Ile Pro Ser Gly Arg Phe Met Arg Glu Leu Cys Gly His Leu Asn Ile 
                645                 650                 655


Ile Tyr Asp Leu Ser Trp Ser Lys Asp Asp His Tyr Ile Leu Thr Ser 
            660                 665                 670


Ser Ser Asp Gly Thr Ala Arg Ile Trp Lys Asn Glu Ile Asn Asn Thr 
        675                 680                 685


Asn Thr Phe Arg Val Leu Pro His Pro Ser Phe Val Tyr Thr Ala Lys 
    690                 695                 700


Phe His Pro Ala Val Arg Glu Leu Val Val Thr Gly Cys Tyr Asp Ser 
705                 710                 715                 720


Met Ile Arg Ile Trp Lys Val Glu Met Arg Glu Asp Ser Ala Ile Leu 
                725                 730                 735


Val Arg Gln Phe Asp Val His Lys Ser Phe Ile Asn Ser Leu Cys Phe 
            740                 745                 750


Asp Thr Glu Gly His His Met Tyr Ser Gly Asp Cys Thr Gly Val Ile 
        755                 760                 765


Val Val Trp Asn Thr Tyr Val Lys Ile Asn Asp Leu Glu His Ser Val 
    770                 775                 780


His His Trp Thr Ile Asn Lys Glu Ile Lys Glu Thr Glu Phe Lys Gly 
785                 790                 795                 800


Ile Pro Ile Ser Tyr Leu Glu Ile His Pro Asn Gly Lys Arg Leu Leu 
                805                 810                 815


Ile His Thr Lys Asp Ser Thr Leu Arg Ile Met Asp Leu Arg Ile Leu 
            820                 825                 830


Val Ala Arg Lys Phe Val Gly Ala Ala Asn Tyr Arg Glu Lys Ile His 
        835                 840                 845


Ser Thr Leu Thr Pro Cys Gly Thr Phe Leu Phe Ala Gly Ser Glu Asp 
    850                 855                 860


Gly Ile Val Tyr Val Trp Asn Pro Glu Thr Gly Glu Gln Val Ala Met 
865                 870                 875                 880


Tyr Ser Asp Leu Pro Phe Lys Ser Pro Ile Arg Asp Ile Ser Tyr His 
                885                 890                 895


Pro Phe Glu Asn Met Val Ala Phe Cys Ala Phe Gly Gln Asn Glu Pro 
            900                 905                 910


Ile Leu Leu Tyr Ile Tyr Asp Phe His Val Ala Gln Gln Glu Ala Glu 
        915                 920                 925


Met Phe Lys Arg Tyr Asn Gly Thr Phe Pro Leu Pro Gly Ile His Gln 
    930                 935                 940


Ser Gln Asp Ala Leu Cys Thr Cys Pro Lys Leu Pro His Gln Gly Ser 
945                 950                 955                 960


Phe Gln Ile Asp Glu Phe Val His Thr Glu Ser Ser Ser Thr Lys Met 
                965                 970                 975


Gln Leu Val Lys Gln Arg Leu Glu Thr Val Thr Glu Val Ile Arg Ser 
            980                 985                 990


Cys Ala Ala Lys Val Asn Lys Asn Leu Ser Phe Thr Ser Pro Pro Ala 
        995                 1000                1005


Val Ser Ser Gln Gln Ser Lys Leu Lys Gln Ser Asn Met Leu Thr Ala 
    1010                1015                1020


Gln Glu Ile Leu His Gln Phe Gly Phe Thr Gln Thr Asp Ser His Phe 
1025                1030                1035                1040


Ala Glu Phe Asn Thr Cys Ile Leu Trp Trp Lys Lys His 
                1045                1050


<210>  3384
<211>  425
<212>  DNA
<213>  Homo sapiens

<400>  3384
atggaacatt tccattacct ggaatacacc aaagtcaaga tgccctatgt acctgtccaa     60

aactacccca tcaaggctct tttcagattg atgaatttgt ccacactgaa agttcttcaa    120

cgaagatgca gctagtaaaa cagaggcttg aaactgtcac agaggtgata cgttcctgtg    180

ctgcaaaagt caacaaaaat ctctcattta cttcaccacc agcagtttcc tcacaacagt    240

ctaagttaaa gcagtcaaac atgctgaccg ctcaagagat tctacatcag tttggtttca    300

ctcagaccgg tgagcccctt tcttactttg acaattcttt taaatgttca gatgcttgtt    360

gtgttgatga atatcactta tttctttaga aataaagctc ataatggtcg gtttttacac    420

ttgac                                                                425


<210>  3385
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  3385

Met Gln Leu Val Lys Gln Arg Leu Glu Thr Val Thr Glu Val Ile Arg 
1               5                   10                  15


Ser Cys Ala Ala Lys Val Asn Lys Asn Leu Ser Phe Thr Ser Pro Pro 
            20                  25                  30


Ala Val Ser Ser Gln Gln Ser Lys Leu Lys Gln Ser Asn Met Leu Thr 
        35                  40                  45


Ala Gln Glu Ile Leu His Gln Phe Gly Phe Thr Gln Thr Gly Glu Pro 
    50                  55                  60


Leu Ser Tyr Phe Asp Asn Ser Phe Lys Cys Ser Asp Ala Cys Cys Val 
65                  70                  75                  80


Asp Glu Tyr His Leu Phe Leu 
                85


<210>  3386
<211>  439
<212>  DNA
<213>  Homo sapiens

<400>  3386
tacaatggca tgatcttgtg tgaagaacgt tttataattt ttatttggaa gttccatatt     60

acaaatacat ctcctttgtt tcgataggat cctgattgag tcaatgcttt gcattctcag    120

tcctctgcat aaagctgaga gatgcctaca gctgagagtg aagcaaaagt aaaaaccaaa    180

gttcgctttg aagaattgct taagacccac agtgatctaa tgcgtgaaaa gaaaaaactg    240

aagaaaaaac ttgtcaggtc tgaagaaaac atctcagtaa gtaaatgatc attgggtaat    300

agtgatttac atatgcgcat aaaatgcaga tatggctgca ttttatgtta aaattctaag    360

gaattttgaa aattaaaaac agtaacacta tgtcatggtc aataacatgt ggtaaaaata    420

aagtttatat tagaatcaa                                                 439


<210>  3387
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  3387

Met Pro Thr Ala Glu Ser Glu Ala Lys Val Lys Thr Lys Val Arg Phe 
1               5                   10                  15


Glu Glu Leu Leu Lys Thr His Ser Asp Leu Met Arg Glu Lys Lys Lys 
            20                  25                  30


Leu Lys Lys Lys Leu Val Arg Ser Glu Glu Asn Ile Ser Val Ser Lys 
        35                  40                  45


<210>  3388
<211>  678
<212>  DNA
<213>  Homo sapiens

<400>  3388
gaacatttta ccagggtgaa aattcaaggt tgaggtagag ggagctacaa agattaaggc     60

accctggaag cacagaagag aagttcttaa atgcccttca aggtgagaat gctctctaga    120

gaagatatca tttgccttta aaggatagtg aggagtttgt tagagagaca aaggaggaag    180

cacatttttc aggggagggg atatgtgtgt aatgatacaa aagcaagaga gaacttggca    240

cacgtgaagg cctgcaggta gtttcacatg tctggaacac agtggatgtg tgaaggggac    300

atttcataaa tggccttgga cctcactgga tcctgattga gtcaatgctt tgcattctca    360

gtcctctgca taaagctgag agatgcctac agctgagagt gaagcaaaag taaaaaccaa    420

agttcgcttt gaagaattgc ttaagaccca cagtgatcta atgcgtgaaa agaaaaaact    480

gaagaaaaaa cttgtcaggt ctgaagaaaa catctcagta agtaaatgat cattgggtaa    540

tagtgattta catatgcgca taaaatgcag atatggctgc attttatgtt aaaattctaa    600

ggaattttga aaattaaaaa cagtaacact atgtcatggt caataacatg tggtaaaaat    660

aaagtttata ttagaatc                                                  678


<210>  3389
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  3389

Met Pro Thr Ala Glu Ser Glu Ala Lys Val Lys Thr Lys Val Arg Phe 
1               5                   10                  15


Glu Glu Leu Leu Lys Thr His Ser Asp Leu Met Arg Glu Lys Lys Lys 
            20                  25                  30


Leu Lys Lys Lys Leu Val Arg Ser Glu Glu Asn Ile Ser Val Ser Lys 
        35                  40                  45


<210>  3390
<211>  1062
<212>  DNA
<213>  Homo sapiens

<400>  3390
atgctcaact ctccggggac acggagacca gtgaaagaag cgcaaaagta cggtgaggac     60

tctcagaaat cgcattcccc cgggacaccc ggcccacgct cgtcggtcac tacgctatca    120

gcctccgcgc tctcggactc cagcagcccc gacacgccgc ccaggagagg gccgggcagg    180

ccgagcaccc cggcccgcgc tcccgccacc agcgcaccca tgatgtactc acggagaggg    240

gtacgcagaa ccgcccgtcc cgccggagcc gacacccgga gcagtgcaaa tcaactcccc    300

cagcctagcg gcgcgtgcgc gaatgcggac agcgcgccgc ctgctgacgt cagcgcctgc    360

ctacgccgcc gttcccatgg cgaccgatgc gtcccgcgct ctaggcgaag accgcggccc    420

cgtccccgcg cctccaccgc cttcttccag gaggaggggc cgtgcggcgc ctgcccgggg    480

gccctcaggc cgcaggcggg cgcgagcttc agggaactta gggggctccc gcctccccgg    540

ccacgcgagc gggaacagtc tcctccactc ggagcggcgc catcttcagc tctgagtcac    600

cagggctgga aaaatactag atgcgctact cgtggactcg tgaatacact cgtgaataca    660

ggccatttcc tgtacctaca gccacccgct ccactcatca tgccttacct ggatgatgca    720

gaagtccctg gaaacagaag gtctcaccct tctttatctt tctcatggct ttccaaggct    780

ctttatcatg ttactttcct gctcagaatt ctttaatgac ttgcctcaat gaccagatac    840

atgtgatcta cagtcagcct tccagcctca tcattcctct tccatttcct ccccagaaac    900

actgtacttt atgaagctcc tccaagacga acctgttgga gaatgtactc cttggaaata    960

aggaagaaag aggatccagg gaacaggagt ttcaccacag aggagcagga aagggaattc   1020

ccagtatgat ggcaagttgc taaattaaat gttttgccca tt                      1062


<210>  3391
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  3391

Met Leu Asn Ser Pro Gly Thr Arg Arg Pro Val Lys Glu Ala Gln Lys 
1               5                   10                  15


Tyr Gly Glu Asp Ser Gln Lys Ser His Ser Pro Gly Thr Pro Gly Pro 
            20                  25                  30


Arg Ser Ser Val Thr Thr Leu Ser Ala Ser Ala Leu Ser Asp Ser Ser 
        35                  40                  45


Ser Pro Asp Thr Pro Pro Arg Arg Gly Pro Gly Arg Pro Ser Thr Pro 
    50                  55                  60


Ala Arg Ala Pro Ala Thr Ser Ala Pro Met Met Tyr Ser Arg Arg Gly 
65                  70                  75                  80


Val Arg Arg Thr Ala Arg Pro Ala Gly Ala Asp Thr Arg Ser Ser Ala 
                85                  90                  95


Asn Gln Leu Pro Gln Pro Ser Gly Ala Cys Ala Asn Ala Asp Ser Ala 
            100                 105                 110


Pro Pro Ala Asp Val Ser Ala Cys Leu Arg Arg Arg Ser His Gly Asp 
        115                 120                 125


Arg Cys Val Pro Arg Ser Arg Arg Arg Pro Arg Pro Arg Pro Arg Ala 
    130                 135                 140


Ser Thr Ala Phe Phe Gln Glu Glu Gly Pro Cys Gly Ala Cys Pro Gly 
145                 150                 155                 160


Ala Leu Arg Pro Gln Ala Gly Ala Ser Phe Arg Glu Leu Arg Gly Leu 
                165                 170                 175


Pro Pro Pro Arg Pro Arg Glu Arg Glu Gln Ser Pro Pro Leu Gly Ala 
            180                 185                 190


Ala Pro Ser Ser Ala Leu Ser His Gln Gly Trp Lys Asn Thr Arg Cys 
        195                 200                 205


Ala Thr Arg Gly Leu Val Asn Thr Leu Val Asn Thr Gly His Phe Leu 
    210                 215                 220


Tyr Leu Gln Pro Pro Ala Pro Leu Ile Met Pro Tyr Leu Asp Asp Ala 
225                 230                 235                 240


Glu Val Pro Gly Asn Arg Arg Ser His Pro Ser Leu Ser Phe Ser Trp 
                245                 250                 255


Leu Ser Lys Ala Leu Tyr His Val Thr Phe Leu Leu Arg Ile Leu 
            260                 265                 270


<210>  3392
<211>  558
<212>  DNA
<213>  Homo sapiens

<400>  3392
gatgcgtccc gcgctctagg cgaagaccgc ggccccgtcc ccgcgcctcc accgccttct     60

tccaggagga ggggccgtgc ggcgcctgcc cgggggccct caggccgcag gcgggcgcga    120

gcttcaggga acttaggggg ctcccgcctc cccggccacg cgagcgggaa cagtctcctc    180

cactcggagc gattatagat ccagactcct gtgcctgacc actgcccatg gccaactctc    240

tgctgatgac tggacttgac tacacaagtt gttggccatc ttaaaaccac tcaaagttga    300

cggtctcctc tcctgcctcc tgcggcttcc attaccatgg cagagactgt ggtgtctgag    360

gtggtgtagc gtactgaagc aaggctgtct tgaagaagag gagacaactc accataaaca    420

acaactcatg cctgcagtgc gctgaaggta tagaaggcct ttggtttagt gaatccaact    480

tctcagctgc agcttcagca taatgacatc ttagaagact ccccagcttc cagtagttta    540

gttagaagtc ctcctctg                                                  558


<210>  3393
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  3393

Cys Val Pro Arg Ser Arg Arg Arg Pro Arg Pro Arg Pro Arg Ala Ser 
1               5                   10                  15


Thr Ala Phe Phe Gln Glu Glu Gly Pro Cys Gly Ala Cys Pro Gly Ala 
            20                  25                  30


Leu Arg Pro Gln Ala Gly Ala Ser Phe Arg Glu Leu Arg Gly Leu Pro 
        35                  40                  45


Pro Pro Arg Pro Arg Glu Arg Glu Gln Ser Pro Pro Leu Gly Ala Ile 
    50                  55                  60


Ile Asp Pro Asp Ser Cys Ala 
65                  70


<210>  3394
<211>  1582
<212>  DNA
<213>  Homo sapiens

<400>  3394
gcctccaccg ccttcttcca ggaggagggg ccgtgcggcg cctgcccggg ggccctcagg     60

ccgcaggcgg gcgcgagctt cagggaactt agggggctcc cgcctccccg gccacgcgag    120

cgggaacagt ctcctccact cggagcgatt atagatccag actcctgtgc ctgaccactg    180

cccatggcca actctctgct gatgactgga cttgactaca caagttgttg gccatcttaa    240

aaccactcaa agttgacggt ctcctctcct gcctcctgcg gcttccatta ccatggcaga    300

gactgtggtg tctgaggtgg tgtagcgtac tgaagcaagg ctgtcttgaa gaagaggaga    360

caactcacaa ttctaccacc tttgttgacc tcttcttccc cccaacttat tgctgtagag    420

gctacctgag ctcattgtcc ctggagatgg accaaataga agaataagca gtgcctgtgt    480

ggtgagcttc aagaggcatc tgttctctgg ggagtgggtg ggtggtaaag caaagacggg    540

agatgtgtat attagctatc cattactgta taattaatta tacacaaaac taaactatac    600

actaaactaa aacttcacag cttaaaacag gaaatatgta ttatctcaca caatttctga    660

gagtcaggaa tctgaaaatg gcttagctag tttggttctg gctcagggtg acctatggag    720

ttgcagccaa gatgtcatct gggactacta tcattggaag gctcagctgg ggctggaggc    780

tacacttcca agatggctca cttatagggc tattggtggg aggcttcagt tcctctccac    840

atgaaacttt cctcatgcca tggaactggc ttccctcaga gtgaaagacc caagagagag    900

actaagacag aagctgcaat gtttttatga cctagtcttg gaagtgactt actgtcattt    960

ctactgtatt ttattcatta gaagcaagtc attaagtcca gcccacattc aaagtaagag   1020

gatttaagct gaacctcttg aaaaaatggt atcaaagtat ttacggacat tttaaaaact   1080

accacaatac atataggtga acttcacaag gtgtagacat gggctgagac agaatattgg   1140

ataatatctc attctgcaaa cagcagcctc atctgtaata aaatcccagc attcagaaat   1200

tatcacgatc aagtaggaaa agggcttgtt ggaaaaaact tatcaaagat gttacttcat   1260

ttatccattt attctgagcc atagcataat agcgacaaat tgtgtgtcct gtgtaatttg   1320

gatacctctg ctcaataata gctgaacaga ttttatccta tttttagaat agttaatata   1380

tacacatggc acaaaattta aaaggtataa aagtttctgg ttcaaaaata agattccctc   1440

attttctttt tttctgattc tttgaatgca attcgattta ctgatttctc atgtagcctt   1500

agaaagtatt ctatgtactt acaaacatat atgtacacat attttttctt tcccacaaat   1560

aaaatactgt atgcattgtt tt                                            1582


<210>  3395
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  3395

Met Glu Leu Ala Ser Leu Arg Val Lys Asp Pro Arg Glu Arg Leu Arg 
1               5                   10                  15


Gln Lys Leu Gln Cys Phe Tyr Asp Leu Val Leu Glu Val Thr Tyr Cys 
            20                  25                  30


His Phe Tyr Cys Ile Leu Phe Ile Arg Ser Lys Ser Leu Ser Pro Ala 
        35                  40                  45


His Ile Gln Ser Lys Arg Ile 
    50                  55


<210>  3396
<211>  437
<212>  DNA
<213>  Homo sapiens

<400>  3396
gtgcggcgcc tgcccggggg ccctcaggcc gcaggcgggc gcgagcttca gggaacttag     60

ggggctcccg cctccccggc cacgcgagcg ggaacagtct cctccactcg gagcgccact    120

catcatgcct tacctggatg atgcagaagt ccctggaaac agaaggtctc acccttcttt    180

atctttctca tggctttcca aggctcttta tcatgttact ttcctgctca gaattcttta    240

atgacttgcc tcaatgacca gatacatgtg atctacagtc agccttccag cctcatcatt    300

cctcttccat ttcctcccca gaaacactgt actttatgaa gctcctccaa gacattatag    360

atccagactc ctgtgcctga ccactgccca tggccaactc tctgctgatg actggacttg    420

actacacaag ttgttgg                                                   437


<210>  3397
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  3397

Met Ala Phe Gln Gly Ser Leu Ser Cys Tyr Phe Pro Ala Gln Asn Ser 
1               5                   10                  15


Leu Met Thr Cys Leu Asn Asp Gln Ile His Val Ile Tyr Ser Gln Pro 
            20                  25                  30


Ser Ser Leu Ile Ile Pro Leu Pro Phe Pro Pro Gln Lys His Cys Thr 
        35                  40                  45


Leu 



<210>  3398
<211>  795
<212>  DNA
<213>  Homo sapiens

<400>  3398
gcggcgcctg cccgggggcc ctcaggccgc aggcgggcgc gagcttcagg gaacttaggg     60

ggctcccgcc tccccggcca cgcgagcggg aacagtctcc tccactcgga gcggcgccat    120

cttcagctct gagtcaccag ggctggaaaa atactagatg cgctactcgt ggactcgtga    180

atacactcgt gaatacaggc catttcctgt acctacagcc acccgctatt atagatccag    240

actcctgtgc ctgaccactg cccatggcca actctctgct gatgactgga cttgactaca    300

caagttgttg gccatcttaa aaccactcaa agttgacggt ctcctctcct gcctcctgcg    360

gcttccatta ccatggcaga gactgtggtg tctgaggtgg tgtagcgtac tgaagcaagg    420

ctgtcttgaa gaagaggaga caactcacaa ttctaccacc tttgttgacc tcttcttccc    480

cccaacttat tgctgtagag gctacctgag ctcattgtcc ctggagatgg accaaataga    540

agaataagca gtgcctgtgt gctgaaggta aagaaatttc atgtggtgga ttcctacaaa    600

agaaaaagct gcaaaagagt caaccaggaa aggtgctaga cacacatcca atggctgctg    660

agtgatgaat gagaaagaaa ccttcggtgt agtaagccat tgaaatttgg gggaaatttg    720

taatagctgt tgctgtaaac ctccgcactg caaaacacac acatcctaga taattaaaag    780

acaacttcta ccaga                                                     795


<210>  3399
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  3399

Met Arg Tyr Ser Trp Thr Arg Glu Tyr Thr Arg Glu Tyr Arg Pro Phe 
1               5                   10                  15


Pro Val Pro Thr Ala Thr Arg Tyr Tyr Arg Ser Arg Leu Leu Cys Leu 
            20                  25                  30


Thr Thr Ala His Gly Gln Leu Ser Ala Asp Asp Trp Thr 
        35                  40                  45


<210>  3400
<211>  681
<212>  DNA
<213>  Homo sapiens

<400>  3400
gcggcgcctg cccgggggcc ctcaggccgc aggcgggcgc gagcttcagg gaacttaggg     60

ggctcccgcc tccccggcca cgcgagcggg aacagtctcc tccactcgga gcgattatag    120

atccagactc ctgtgcctga ccactgccca tggccaactc tctgctgatg actggacttg    180

actacacaag ttgttggcca tcttaaaacc actcaaagtt gacggtctcc tctcctgcct    240

cctgcggctt ccattaccat ggcagagact gtggtgtctg aggtggtgta gcgtactgaa    300

gcaaggctgt cttgaagaag aggagacaac tcacaattct accacctttg ttgacctctt    360

cttcccccca acttattgct gtagaggcta cctgagctca ttgtccctgg agatggacca    420

aatagaagaa taagcagtgc ctgtgtgctg aaggtaaaga aatttcatgt ggtggattcc    480

tacaaaagaa aaagctgcaa aagagtcaac caggaaaggt gctagacaca catccaatgg    540

ctgctgagtg atgaatgaga aagaaacctt cggtgtagta agccattgaa atttggggga    600

aatttgtaat agctgttgct gtaaacctcc gcactgcaaa acacacacat cctagataat    660

taaaagacaa cttctaccag a                                              681


<210>  3401
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  3401

Arg Leu Pro Glu Leu Ile Val Pro Gly Asp Gly Pro Asn Arg Arg Ile 
1               5                   10                  15


Ser Ser Ala Cys Val Leu Lys Val Lys Lys Phe His Val Val Asp Ser 
            20                  25                  30


Tyr Lys Arg Lys Ser Cys Lys Arg Val Asn Gln Glu Arg Cys 
        35                  40                  45


<210>  3402
<211>  458
<212>  DNA
<213>  Homo sapiens

<400>  3402
aacttagggg gctcccgcct ccccggccac gcgagcggga acagtctcct ccactcggag     60

cggcgccatc ttcagctctg agtcaccagg gctggaaaaa tactagatgc gctactcgtg    120

gactcgtgaa tacactcgtg aatacaggcc atttcctgta cctacagcca cccgcttttc    180

ttctcccagt gacctctatt aacagagcct acatggaacc agccggcaaa gacaagttcc    240

actgtcacaa ctagagaaaa gaggatgggt ttggaattga aaggcttggc tgttgttgat    300

ataaaggaat gcagctaacc agggagatgg aaaatctcta cagtgagagc cacaaaacac    360

ttctcaaaga aatcagagat gacacagaca aatggaaaaa cattacatgc ttatggatag    420

gaagaatcaa tatcattaaa atggccatac tgcccaaa                            458


<210>  3403
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  3403

Met Arg Tyr Ser Trp Thr Arg Glu Tyr Thr Arg Glu Tyr Arg Pro Phe 
1               5                   10                  15


Pro Val Pro Thr Ala Thr Arg Phe Ser Ser Pro Ser Asp Leu Tyr 
            20                  25                  30


<210>  3404
<211>  514
<212>  DNA
<213>  Homo sapiens

<400>  3404
gcgagcggga acagtctcct ccactcggag cggcgccatc ttcagctctg agtcaccagg     60

gctggaaaaa tactagatgc gctactcgtg gactcgtgaa tacactcgtg aatacaggcc    120

atttcctgta cctacagcca cccgctggca tgggaagagg accatagttt ctgtggcctc    180

cctaagatgg cctgccacct ctcctgatgc tggtgacttc ttgtgatggt ggggcaatat    240

taagtgtttg aaaaaggaag aagttcttat tcccaaagtt gtattcagtt atcaaaacaa    300

caattatttt gtataaactg catcagagac aactgaagat gaaagaacta ccatctccac    360

atataactaa tttgtgcagt gcaccagaaa gaacctgttt aaatttccat gccaatttgc    420

aacccccata ctgtgccaga ttatagatcc agactcctgt gcctgaccac tgcccatggc    480

caactctctg ctgatgactg gacttgacta caca                                514


<210>  3405
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  3405

Met Arg Tyr Ser Trp Thr Arg Glu Tyr Thr Arg Glu Tyr Arg Pro Phe 
1               5                   10                  15


Pro Val Pro Thr Ala Thr Arg Trp His Gly Lys Arg Thr Ile Val Ser 
            20                  25                  30


Val Ala Ser Leu Arg Trp Pro Ala Thr Ser Pro Asp Ala Gly Asp Phe 
        35                  40                  45


Leu 



<210>  3406
<211>  400
<212>  DNA
<213>  Homo sapiens

<400>  3406
atgggaaaga agagaacgta tttgtaaaga taacagacag ccaaatgtca taatggtcag     60

ccttgcatac attaatgaca ttttctttct attatttttt tcctatctta aatggaaggt    120

gtcagataaa ctgccgaata cttactgtta ccctggaaac atgaaggact tgaatatttg    180

tggaatcatg acagaacagg ttgaaaaata ttaagaggcg agagctagag agagaagatt    240

acctagtaaa aattcttttg aaataaacta tatatgtgaa agtcaagatt gtggactaac    300

cacacacatt tatattattt tattcctaat aacccagtaa gtggttataa aggatacata    360

cacacacaca cacacattca catacacaat tattatatat                          400


<210>  3407
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  3407

Met Val Ser Leu Ala Tyr Ile Asn Asp Ile Phe Phe Leu Leu Phe Phe 
1               5                   10                  15


Ser Tyr Leu Lys Trp Lys Val Ser Asp Lys Leu Pro Asn Thr Tyr Cys 
            20                  25                  30


Tyr Pro Gly Asn Met Lys Asp Leu Asn Ile Cys Gly Ile Met Thr Glu 
        35                  40                  45


Gln Val Glu Lys Tyr 
    50


<210>  3408
<211>  531
<212>  DNA
<213>  Homo sapiens

<400>  3408
tgaaattgtc tgagttttga caattataat attttatttc tgattaatca gaaaatagtt     60

tgccataaaa atttatcact tctgatatta gcacataaat ttgtttttat tgtaatttca    120

aaactaatgt caagactgag caaatcataa gatggaagca cctgtgagtg cctgggaccc    180

tcaagatcat caaatccagc tttccctgca gagatggtct ttcaactttt gcctgaacat    240

catccttgtg agggaaatcg tttcatcaca aagcaatcca gtttactact ggaacactgc    300

aattatttga agatttttgg catcacatgt cacaacattg cttcatatga attggtactt    360

aaaagaaaac tcgacgccat agaactacaa aattaaatcc aggaagaacc tcagagacga    420

tcttcttcca acatcctctt tctcagataa ggaaattaag gttttaaaag atcttgtgcc    480

aaaagtcaca cagttgactt gtggcagtta agattaaatt ttaaaattcc t             531


<210>  3409
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  3409

Met Val Phe Gln Leu Leu Pro Glu His His Pro Cys Glu Gly Asn Arg 
1               5                   10                  15


Phe Ile Thr Lys Gln Ser Ser Leu Leu Leu Glu His Cys Asn Tyr Leu 
            20                  25                  30


Lys Ile Phe Gly Ile Thr Cys His Asn Ile Ala Ser Tyr Glu Leu Val 
        35                  40                  45


Leu Lys Arg Lys Leu Asp Ala Ile Glu Leu Gln Asn 
    50                  55                  60


<210>  3410
<211>  934
<212>  DNA
<213>  Homo sapiens

<400>  3410
gaaagaacct gtttaaattt ccatgccaat ttgcaacccc catactgtgc cagattatag     60

atccagactc ctgtgcctga ccactgccca tggccaactc tctgctgatg actggacttg    120

actacacaag ttgttgggta ctttgactag aacaccaacc aagtcattgg aaatataatg    180

ctttgttctt tctagctcca agatatgaac atgtgacaac ccaaacaaac aaaatcccaa    240

caaggttgtc agatatgcaa attacagttg acccttgaac aacagagagg gtagaggtgc    300

tgatcactgg cacagttgaa aattcaaaag ttttgactcc cctaaaactt aattactaat    360

aacctactgt tgactagaag cctactgata atataaacga tttattaaca catattttat    420

atgttatatg tattaggtac tgtattataa taaagtaagc tagagcaaag aaaatgttat    480

ggataaaatc ataagaaaga gaaaagatat ttactctcca ttgaatagaa atggctcatc    540

ataaagatct tcattctcac catcttcaaa ttgggtaggc tgaagaggag caataagaga    600

aggggttggt cttgccatct caggtgtggc agagacggaa aacaatccac gtataaatat    660

ggacccatgt agttcaaacc tgtgttgttc aaaggtcaac tgtatttact ttaaattact    720

tgtctgacct gagattttcc tgaccataat ccaagagatt gacacctttc taaagtttgt    780

tcttatgttt tccaaaatga caacttgttt tccagaagtt agcagccacc atgttttaag    840

acagaaacag cctgaggttc tcccaaggtc tattgagcat aagagttttt tgccttctag    900

taaaataaac ccatattcgc agagtgtctg gacc                                934


<210>  3411
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  3411

Met Pro Ile Cys Asn Pro His Thr Val Pro Asp Tyr Arg Ser Arg Leu 
1               5                   10                  15


Leu Cys Leu Thr Thr Ala His Gly Gln Leu Ser Ala Asp Asp Trp Thr 
            20                  25                  30


<210>  3412
<211>  6854
<212>  DNA
<213>  Homo sapiens

<400>  3412
agtgctgaag aaagagggca ctagtgtaca gcccagatcg catccttgca ccgtctggat     60

tagagctgag gcgtctgcaa gccgagcgtg gccacggtcc tctggccccg ggaccatagc    120

gctgtctacc ccgactcagg tactcagcat ctagctcacc gctgccaaca cgacttccac    180

tgtactcttg atcaatttac cttgatgcac taccggtgaa gaacggggac tcgaattccc    240

ttacaaacgc ctccagcttg tagaggcggt cgtggaggac ccagaggagg agacgaaggg    300

gaaggaggcg gtggtggagg aggcaaaggc cttggacgac cattgttggc gaggggcacc    360

actccgggag aggcggcgct gggcgtcttg ggggtgcgcg ccgggagcct gcagcgggac    420

cagcgtggga acgcggctgg caggctgtgg acctcgtcct caccaccatg gtcgggctcc    480

ttttgttttt tttcccagcg atctttttgg aggtgtccct tctccccaga agccccggca    540

ggaaagtgtt gctggcagga gcgtcgtctc agcgctcggt ggccagaatg gacggagatg    600

tcatcattgg agccctcttc tcagtccatc accagcctcc ggccgagaaa gtgcccgaga    660

ggaagtgtgg ggagatcagg gagcagtatg gcatccagag ggtggaggcc atgttccaca    720

cgttggataa gatcaacgcg gacccggtcc tcctgcccaa catcaccctg ggcagtgaga    780

tccgggactc ctgctggcac tcttccgtgg ctctggaaca gagcattgag ttcattaggg    840

actctctgat ttccattcga gatgagaagg atgggatcaa ccggtgtctg cctgacggcc    900

agtccctccc cccaggcagg actaagaagc ccattgcggg agtgatcggt cccggctcca    960

gctctgtagc cattcaagtg cagaacctgc tccagctctt cgacatcccc cagatcgctt   1020

attcagccac aagcatcgac ctgagtgaca aaactttgta caaatacttc ctgagggttg   1080

tcccttctga cactttgcag gcaagggcca tgcttgacat agtcaaacgt tacaattgga   1140

cctatgtctc tgcagtccac acggaaggga attatgggga gagcggaatg gacgctttca   1200

aagagctggc tgcccaggaa ggcctctgta tcgcccattc tgacaaaatc tacagcaacg   1260

ctggggagaa gagctttgac cgactcttgc gcaaactccg agagaggctt cccaaggcta   1320

gagtggtggt ctgcttctgt gaaggcatga cagtgcgagg actcctgagc gccatgcggc   1380

gccttggcgt cgtgggcgag ttctcactca ttggaagtga tggatgggca gacagagatg   1440

aagtcattga aggttatgag gtggaagcca acgggggaat cacgataaag ctgcagtctc   1500

cagaggtcag gtcatttgat gattatttcc tgaaactgag gctggacact aacacgagga   1560

atccctggtt ccctgagttc tggcaacatc ggttccagtg ccgccttcca ggacaccttc   1620

tggaaaatcc caactttaaa cgaatctgca caggcaatga aagcttagaa gaaaactatg   1680

tccaggacag taagatgggg tttgtcatca atgccatcta tgccatggca catgggctgc   1740

agaacatgca ccatgccctc tgccctggcc acgtgggcct ctgcgatgcc atgaagccca   1800

tcgacggcag caagctgctg gacttcctca tcaagtcctc attcattgga gtatctggag   1860

aggaggtgtg gtttgatgag aaaggagacg ctcctggaag gtatgatatc atgaatctgc   1920

agtacactga agctaatcgc tatgactatg tgcacgttgg aacctggcat gaaggagtgc   1980

tgaacattga tgattacaaa atccagatga acaagagtgg agtggtgcgg tctgtgtgca   2040

gtgagccttg cttaaagggc cagattaagg ttatacggaa aggagaagtg agctgctgct   2100

ggatttgcac ggcctgcaaa gagaatgaat atgtgcaaga tgagttcacc tgcaaagctt   2160

gtgacttggg atggtggccc aatgcagatc taacaggctg tgagcccatt cctgtgcgct   2220

atcttgagtg gagcaacatc gaatccatta tagccatcgc cttttcatgc ctgggaatcc   2280

ttgttacctt gtttgtcacc ctaatctttg tactgtaccg ggacacacca gtggtcaaat   2340

cctccagtcg ggagctctgc tacatcatcc tagctggcat cttccttggt tatgtgtgcc   2400

cattcactct cattgccaaa cctactacca cctcctgcta cctccagcgc ctcttggttg   2460

gcctctcctc tgcgatgtgc tactctgctt tagtgactaa aaccaatcgt attgcacgca   2520

tcctggctgg cagcaagaag aagatctgca cccggaagcc caggttcatg agtgcctggg   2580

ctcaggtgat cattgcctca attctgatta gtgtgcaact aaccctggtg gtaaccctga   2640

tcatcatgga accccctatg cccattctgt cctacccaag tatcaaggaa gtctacctta   2700

tctgcaatac cagcaacctg ggtgtggtgg cccctttggg ctacaatgga ctcctcatca   2760

tgagctgtac ctactatgcc ttcaagaccc gcaacgtgcc cgccaacttc aacgaggcca   2820

aatatatcgc gttcaccatg tacaccacct gtatcatctg gctagctttt gtgcccattt   2880

actttgggag caactacaag atcatcacaa cttgctttgc agtgagtctc agtgtaacag   2940

tggctctggg gtgcatgttc actcccaaga tgtacatcat tattgccaag cctgagagga   3000

atgtccgcag tgccttcacc acctctgatg ttgtccgcat gcatgttggc gatggcaagc   3060

tgccctgccg ctccaacact ttcctcaaca tcttccgaag aaagaaggca ggggcaggga   3120

atgccaattc taatggcaag tctgtgtcat ggtctgaacc aggtggagga caggtgccca   3180

agggacagca tatgtggcac cgcctctctg tgcacgtgaa gaccaatgag acggcctgca   3240

accaaacagc cgtcatcaag cccctcacta aaagttacca aggctctggc aagagcctga   3300

ccttttcaga taccagcacc aagacccttt acaacgtaga ggaggaggag gatgcccagc   3360

cgattcgctt tagcccgcct ggtagccctt ccatggtggt gcacaggcgc gtgccaagcg   3420

cggcgaccac tccgcctctg ccgtcccacc tgaccgcaga ggagaccccc ctcttcctgg   3480

ccgaaccagc cctccccaag ggcttgcccc ctcctctcca gcagcagcag caaccccctc   3540

cacagcagaa atcgctgatg gaccagctcc agggagtggt cagcaacttc agtaccgcga   3600

tcccggattt tcacgcggtg ctggcaggcc ccggtggtcc cgggaacggg ctgcggtccc   3660

tgtacccgcc cccgccacct ccgcagcacc tgcagatgct gccgctgcag ctgagcacct   3720

ttggggagga gctggtctcc ccgcccgcgg acgacgacga cgacagcgag aggtttaagc   3780

tcctccagga gtacgtgtat gagcacgagc gggaagggaa cacggaagaa gacgaactgg   3840

aagaggagga ggaggacctg caggcggcca gcaaactgac cccggatgat tcgcctgcgc   3900

tgacgcctcc gtcgcctttc cgcgactcgg tggcctcggg cagctcggtg cccagctccc   3960

ccgtgtccga gtcggtgctc tgcacccctc ccaacgtatc ctacgcctct gtcattctgc   4020

gggactacaa gcaaagctct tccaccctgt aagggggaag ggtccacata gaaaagcaag   4080

acaagccaga gatctcccac acctccagag atgtgcaaac agctgggagg aaaagcctgg   4140

gagtgggggg cctcgtcggg aggacaggag accgctgctg ctgctgccgc tactgctgct   4200

gctgccttaa gtaggaagag agggaaggac accaagcaaa aaatgttcca ggccaggatt   4260

cggattcttg aattactcga agccttctct gggaagaaag ggaattctga caaagcacaa   4320

ttccatatgg tatgtaactt ttatcacaaa tcaaatagtg acatcacaaa cataatgtcc   4380

tcttttgcac aattgtgcat agatatatat atgcccacac acactgggcc atgcttgcca   4440

aggaacagcc cacgtggaca tgccagtcgg atcatgagtt cacctgatgg cattcggagt   4500

gagctggtgg agccagacag agcaggtgcg gggaagggaa gggcccaggc cagacccatc   4560

ccaaacggat gatgggatga tgggacagca gctccttgct cagaagccct tctccccgct   4620

gggctgacag actcctcatc ttcaggagac tcaggaatgg agcggcacag gggtctctct   4680

tcatccactg caacccatcc agtgccagct ttgagattgc acttgaagaa aggtgcatgg   4740

accccctgct gctctgcaga ttccctttat ttaggaaaac aggaataaga gcaaaattat   4800

caccaaaaag tgcttcatca ggcgtgctac aggaggaagg agctagaaat agaacaatcc   4860

atcagcatga gactttgaaa aaaaaacaca tgatcagctt ctcatgttcc atattcactt   4920

attggcgatt tggggaaaag gccggaacaa gagattgtta cgagagtggc agaaaccctt   4980

ttgtagattg acttgtgttt gtgccaagcg ggctttccat tgaccttcag ttaaagaaca   5040

aaccatgtga caaaattgtt accttccact tactgtagca aataatacct acaagttgaa   5100

cttctaagat gcgtatatgt acaatttggt gccattattt ctcctacgta ttagagaaac   5160

aaatccatct ttgaatctaa tggtgtactc atagcaacta ttactggttt aaatgacaaa   5220

taattctatc ctattgtcac tgaagtcctt gtaactagcg agtgaatgtg ttcctgtgtc   5280

cttgtatatg tgcgatcgta aaatttgtgc aatgtaatgt caaattgact ggtcaatgtc   5340

aacctagtag tcaatctaac tgcaattaga aattgtcttt tgaatatact atatatattt   5400

tttatgttcc aataatgttt tgtacatcat tgtcatcaat atctacagaa gctctttgac   5460

ggtttgaata ctatggctca aggttttcat atgcagctcg gatggacatt tttcttctaa   5520

gatggaactt atttttcaga tattttctga tgtggagata tgttattaat gaagtggttt   5580

gaaaatttgt tatattaaaa gtgcacaaaa actgagagtg aaaataaaag gtacatttta   5640

taagcttgca cacattatta acacataaga ttgaacaaag catttagatt attccaggtt   5700

atatcatttt tttaaagatt ttccacagct acttgagtgt ctaacataca gtaacatcta   5760

actcagctaa taatttgtaa aatctttatc aatcacattt tgccttcttt taatttttat   5820

gttcatggac ttttattcct gtgtcttggc tgtcataact ttttatttct gctatttgct   5880

gttgtgtaat atccatggac atgtaatcca cttactccat ctttacaatc cctttttacc   5940

accaataaaa ggatttttct tgctgttttg atttcttcta ttatttgtgg aatgaattat   6000

acccccctta aatatctttg tttatgcctt atgttcagtc atattttaat atgcttcctt   6060

catattgaag ctgctgattt ctcagccaaa aatcatctta gaatctttaa atatccattg   6120

catcatttgt tcagaattta acatccattc caatgttgga ggcttgtatt acttatattt   6180

catcatattc tattgccaag tttagtcagt tccacaccaa gaatgaactg catttccttt   6240

aaaaattatt ttaaaacacc tttattgaaa agatctcatg actgagatgt ggactttggt   6300

tccatgtttt cattgtaaga aagcagagag cggaaaatca atggctccag tgattaatag   6360

atgggttttt agtaattgac aaattcatga gggaaagcat atgatctctt tattagtgaa   6420

tcatgcttat tttttactct taatgccact aatatacatc cctaatatca cagggcttgt   6480

gcattcagat ttttaaaaaa ttaggataga taaggaaaca acttatattc aagtgtaaga   6540

tgatatcagg ttggtctaag acttttggtg aacacgttca ttcaactgtg atcactttat   6600

tactctgaat gcctactatt atcctgatta tggggtctcc tgaataaata gagtattagt   6660

ccttatgtca tcattgttca aaattggaga tgtacacata cataccctat accaagaggg   6720

ccgaaactct tcaccttgat gtatgttctg atacaagttg ttcagcttct tgtaaatgtg   6780

ttttccttcg gcttgttact gccttttgtc aaataatctt gacaatgctg tataataaat   6840

attttctatt tatt                                                     6854


<210>  3413
<211>  1194
<212>  PRT
<213>  Homo sapiens

<400>  3413

Met Val Gly Leu Leu Leu Phe Phe Phe Pro Ala Ile Phe Leu Glu Val 
1               5                   10                  15


Ser Leu Leu Pro Arg Ser Pro Gly Arg Lys Val Leu Leu Ala Gly Ala 
            20                  25                  30


Ser Ser Gln Arg Ser Val Ala Arg Met Asp Gly Asp Val Ile Ile Gly 
        35                  40                  45


Ala Leu Phe Ser Val His His Gln Pro Pro Ala Glu Lys Val Pro Glu 
    50                  55                  60


Arg Lys Cys Gly Glu Ile Arg Glu Gln Tyr Gly Ile Gln Arg Val Glu 
65                  70                  75                  80


Ala Met Phe His Thr Leu Asp Lys Ile Asn Ala Asp Pro Val Leu Leu 
                85                  90                  95


Pro Asn Ile Thr Leu Gly Ser Glu Ile Arg Asp Ser Cys Trp His Ser 
            100                 105                 110


Ser Val Ala Leu Glu Gln Ser Ile Glu Phe Ile Arg Asp Ser Leu Ile 
        115                 120                 125


Ser Ile Arg Asp Glu Lys Asp Gly Ile Asn Arg Cys Leu Pro Asp Gly 
    130                 135                 140


Gln Ser Leu Pro Pro Gly Arg Thr Lys Lys Pro Ile Ala Gly Val Ile 
145                 150                 155                 160


Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn Leu Leu Gln 
                165                 170                 175


Leu Phe Asp Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser Ile Asp Leu 
            180                 185                 190


Ser Asp Lys Thr Leu Tyr Lys Tyr Phe Leu Arg Val Val Pro Ser Asp 
        195                 200                 205


Thr Leu Gln Ala Arg Ala Met Leu Asp Ile Val Lys Arg Tyr Asn Trp 
    210                 215                 220


Thr Tyr Val Ser Ala Val His Thr Glu Gly Asn Tyr Gly Glu Ser Gly 
225                 230                 235                 240


Met Asp Ala Phe Lys Glu Leu Ala Ala Gln Glu Gly Leu Cys Ile Ala 
                245                 250                 255


His Ser Asp Lys Ile Tyr Ser Asn Ala Gly Glu Lys Ser Phe Asp Arg 
            260                 265                 270


Leu Leu Arg Lys Leu Arg Glu Arg Leu Pro Lys Ala Arg Val Val Val 
        275                 280                 285


Cys Phe Cys Glu Gly Met Thr Val Arg Gly Leu Leu Ser Ala Met Arg 
    290                 295                 300


Arg Leu Gly Val Val Gly Glu Phe Ser Leu Ile Gly Ser Asp Gly Trp 
305                 310                 315                 320


Ala Asp Arg Asp Glu Val Ile Glu Gly Tyr Glu Val Glu Ala Asn Gly 
                325                 330                 335


Gly Ile Thr Ile Lys Leu Gln Ser Pro Glu Val Arg Ser Phe Asp Asp 
            340                 345                 350


Tyr Phe Leu Lys Leu Arg Leu Asp Thr Asn Thr Arg Asn Pro Trp Phe 
        355                 360                 365


Pro Glu Phe Trp Gln His Arg Phe Gln Cys Arg Leu Pro Gly His Leu 
    370                 375                 380


Leu Glu Asn Pro Asn Phe Lys Arg Ile Cys Thr Gly Asn Glu Ser Leu 
385                 390                 395                 400


Glu Glu Asn Tyr Val Gln Asp Ser Lys Met Gly Phe Val Ile Asn Ala 
                405                 410                 415


Ile Tyr Ala Met Ala His Gly Leu Gln Asn Met His His Ala Leu Cys 
            420                 425                 430


Pro Gly His Val Gly Leu Cys Asp Ala Met Lys Pro Ile Asp Gly Ser 
        435                 440                 445


Lys Leu Leu Asp Phe Leu Ile Lys Ser Ser Phe Ile Gly Val Ser Gly 
    450                 455                 460


Glu Glu Val Trp Phe Asp Glu Lys Gly Asp Ala Pro Gly Arg Tyr Asp 
465                 470                 475                 480


Ile Met Asn Leu Gln Tyr Thr Glu Ala Asn Arg Tyr Asp Tyr Val His 
                485                 490                 495


Val Gly Thr Trp His Glu Gly Val Leu Asn Ile Asp Asp Tyr Lys Ile 
            500                 505                 510


Gln Met Asn Lys Ser Gly Val Val Arg Ser Val Cys Ser Glu Pro Cys 
        515                 520                 525


Leu Lys Gly Gln Ile Lys Val Ile Arg Lys Gly Glu Val Ser Cys Cys 
    530                 535                 540


Trp Ile Cys Thr Ala Cys Lys Glu Asn Glu Tyr Val Gln Asp Glu Phe 
545                 550                 555                 560


Thr Cys Lys Ala Cys Asp Leu Gly Trp Trp Pro Asn Ala Asp Leu Thr 
                565                 570                 575


Gly Cys Glu Pro Ile Pro Val Arg Tyr Leu Glu Trp Ser Asn Ile Glu 
            580                 585                 590


Ser Ile Ile Ala Ile Ala Phe Ser Cys Leu Gly Ile Leu Val Thr Leu 
        595                 600                 605


Phe Val Thr Leu Ile Phe Val Leu Tyr Arg Asp Thr Pro Val Val Lys 
    610                 615                 620


Ser Ser Ser Arg Glu Leu Cys Tyr Ile Ile Leu Ala Gly Ile Phe Leu 
625                 630                 635                 640


Gly Tyr Val Cys Pro Phe Thr Leu Ile Ala Lys Pro Thr Thr Thr Ser 
                645                 650                 655


Cys Tyr Leu Gln Arg Leu Leu Val Gly Leu Ser Ser Ala Met Cys Tyr 
            660                 665                 670


Ser Ala Leu Val Thr Lys Thr Asn Arg Ile Ala Arg Ile Leu Ala Gly 
        675                 680                 685


Ser Lys Lys Lys Ile Cys Thr Arg Lys Pro Arg Phe Met Ser Ala Trp 
    690                 695                 700


Ala Gln Val Ile Ile Ala Ser Ile Leu Ile Ser Val Gln Leu Thr Leu 
705                 710                 715                 720


Val Val Thr Leu Ile Ile Met Glu Pro Pro Met Pro Ile Leu Ser Tyr 
                725                 730                 735


Pro Ser Ile Lys Glu Val Tyr Leu Ile Cys Asn Thr Ser Asn Leu Gly 
            740                 745                 750


Val Val Ala Pro Leu Gly Tyr Asn Gly Leu Leu Ile Met Ser Cys Thr 
        755                 760                 765


Tyr Tyr Ala Phe Lys Thr Arg Asn Val Pro Ala Asn Phe Asn Glu Ala 
    770                 775                 780


Lys Tyr Ile Ala Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala 
785                 790                 795                 800


Phe Val Pro Ile Tyr Phe Gly Ser Asn Tyr Lys Ile Ile Thr Thr Cys 
                805                 810                 815


Phe Ala Val Ser Leu Ser Val Thr Val Ala Leu Gly Cys Met Phe Thr 
            820                 825                 830


Pro Lys Met Tyr Ile Ile Ile Ala Lys Pro Glu Arg Asn Val Arg Ser 
        835                 840                 845


Ala Phe Thr Thr Ser Asp Val Val Arg Met His Val Gly Asp Gly Lys 
    850                 855                 860


Leu Pro Cys Arg Ser Asn Thr Phe Leu Asn Ile Phe Arg Arg Lys Lys 
865                 870                 875                 880


Ala Gly Ala Gly Asn Ala Asn Ser Asn Gly Lys Ser Val Ser Trp Ser 
                885                 890                 895


Glu Pro Gly Gly Gly Gln Val Pro Lys Gly Gln His Met Trp His Arg 
            900                 905                 910


Leu Ser Val His Val Lys Thr Asn Glu Thr Ala Cys Asn Gln Thr Ala 
        915                 920                 925


Val Ile Lys Pro Leu Thr Lys Ser Tyr Gln Gly Ser Gly Lys Ser Leu 
    930                 935                 940


Thr Phe Ser Asp Thr Ser Thr Lys Thr Leu Tyr Asn Val Glu Glu Glu 
945                 950                 955                 960


Glu Asp Ala Gln Pro Ile Arg Phe Ser Pro Pro Gly Ser Pro Ser Met 
                965                 970                 975


Val Val His Arg Arg Val Pro Ser Ala Ala Thr Thr Pro Pro Leu Pro 
            980                 985                 990


Ser His Leu Thr Ala Glu Glu Thr Pro Leu Phe Leu Ala Glu Pro Ala 
        995                 1000                1005


Leu Pro Lys Gly Leu Pro Pro Pro Leu Gln Gln Gln Gln Gln Pro Pro 
    1010                1015                1020


Pro Gln Gln Lys Ser Leu Met Asp Gln Leu Gln Gly Val Val Ser Asn 
1025                1030                1035                1040


Phe Ser Thr Ala Ile Pro Asp Phe His Ala Val Leu Ala Gly Pro Gly 
                1045                1050                1055


Gly Pro Gly Asn Gly Leu Arg Ser Leu Tyr Pro Pro Pro Pro Pro Pro 
            1060                1065                1070


Gln His Leu Gln Met Leu Pro Leu Gln Leu Ser Thr Phe Gly Glu Glu 
        1075                1080                1085


Leu Val Ser Pro Pro Ala Asp Asp Asp Asp Asp Ser Glu Arg Phe Lys 
    1090                1095                1100


Leu Leu Gln Glu Tyr Val Tyr Glu His Glu Arg Glu Gly Asn Thr Glu 
1105                1110                1115                1120


Glu Asp Glu Leu Glu Glu Glu Glu Glu Asp Leu Gln Ala Ala Ser Lys 
                1125                1130                1135


Leu Thr Pro Asp Asp Ser Pro Ala Leu Thr Pro Pro Ser Pro Phe Arg 
            1140                1145                1150


Asp Ser Val Ala Ser Gly Ser Ser Val Pro Ser Ser Pro Val Ser Glu 
        1155                1160                1165


Ser Val Leu Cys Thr Pro Pro Asn Val Ser Tyr Ala Ser Val Ile Leu 
    1170                1175                1180


Arg Asp Tyr Lys Gln Ser Ser Ser Thr Leu 
1185                1190


<210>  3414
<211>  6836
<212>  DNA
<213>  Homo sapiens

<400>  3414
caggtactca ggtatgtctc aagtccatgt cctccaaaca gactcagcat ctagctcacc     60

gctgccaaca cgacttccac tgtactcttg atcaatttac cttgatgcac taccggtgaa    120

gaacggggac tcgaattccc ttacaaacgc ctccagcttg tagaggcggt cgtggaggac    180

ccagaggagg agacgaaggg gaaggaggcg gtggtggagg aggcaaaggc cttggacgac    240

cattgttggc gaggggcacc actccgggag aggcggcgct gggcgtcttg ggggtgcgcg    300

ccgggagcct gcagcgggac cagcgtggga acgcggctgg caggctgtgg acctcgtcct    360

caccaccatg gtcgggctcc ttttgttttt tttcccagcg atctttttgg aggtgtccct    420

tctccccaga agccccggca ggaaagtgtt gctggcagga gcgtcgtctc agcgctcggt    480

ggccagaatg gacggagatg tcatcattgg agccctcttc tcagtccatc accagcctcc    540

ggccgagaaa gtgcccgaga ggaagtgtgg ggagatcagg gagcagtatg gcatccagag    600

ggtggaggcc atgttccaca cgttggataa gatcaacgcg gacccggtcc tcctgcccaa    660

catcaccctg ggcagtgaga tccgggactc ctgctggcac tcttccgtgg ctctggaaca    720

gagcattgag ttcattaggg actctctgat ttccattcga gatgagaagg atgggatcaa    780

ccggtgtctg cctgacggcc agtccctccc cccaggcagg actaagaagc ccattgcggg    840

agtgatcggt cccggctcca gctctgtagc cattcaagtg cagaacctgc tccagctctt    900

cgacatcccc cagatcgctt attcagccac aagcatcgac ctgagtgaca aaactttgta    960

caaatacttc ctgagggttg tcccttctga cactttgcag gcaagggcca tgcttgacat   1020

agtcaaacgt tacaattgga cctatgtctc tgcagtccac acggaaggga attatgggga   1080

gagcggaatg gacgctttca aagagctggc tgcccaggaa ggcctctgta tcgcccattc   1140

tgacaaaatc tacagcaacg ctggggagaa gagctttgac cgactcttgc gcaaactccg   1200

agagaggctt cccaaggcta gagtggtggt ctgcttctgt gaaggcatga cagtgcgagg   1260

actcctgagc gccatgcggc gccttggcgt cgtgggcgag ttctcactca ttggaagtga   1320

tggatgggca gacagagatg aagtcattga aggttatgag gtggaagcca acgggggaat   1380

cacgataaag ctgcagtctc cagaggtcag gtcatttgat gattatttcc tgaaactgag   1440

gctggacact aacacgagga atccctggtt ccctgagttc tggcaacatc ggttccagtg   1500

ccgccttcca ggacaccttc tggaaaatcc caactttaaa cgaatctgca caggcaatga   1560

aagcttagaa gaaaactatg tccaggacag taagatgggg tttgtcatca atgccatcta   1620

tgccatggca catgggctgc agaacatgca ccatgccctc tgccctggcc acgtgggcct   1680

ctgcgatgcc atgaagccca tcgacggcag caagctgctg gacttcctca tcaagtcctc   1740

attcattgga gtatctggag aggaggtgtg gtttgatgag aaaggagacg ctcctggaag   1800

gtatgatatc atgaatctgc agtacactga agctaatcgc tatgactatg tgcacgttgg   1860

aacctggcat gaaggagtgc tgaacattga tgattacaaa atccagatga acaagagtgg   1920

agtggtgcgg tctgtgtgca gtgagccttg cttaaagggc cagattaagg ttatacggaa   1980

aggagaagtg agctgctgct ggatttgcac ggcctgcaaa gagaatgaat atgtgcaaga   2040

tgagttcacc tgcaaagctt gtgacttggg atggtggccc aatgcagatc taacaggctg   2100

tgagcccatt cctgtgcgct atcttgagtg gagcaacatc gaatccatta tagccatcgc   2160

cttttcatgc ctgggaatcc ttgttacctt gtttgtcacc ctaatctttg tactgtaccg   2220

ggacacacca gtggtcaaat cctccagtcg ggagctctgc tacatcatcc tagctggcat   2280

cttccttggt tatgtgtgcc cattcactct cattgccaaa cctactacca cctcctgcta   2340

cctccagcgc ctcttggttg gcctctcctc tgcgatgtgc tactctgctt tagtgactaa   2400

aaccaatcgt attgcacgca tcctggctgg cagcaagaag aagatctgca cccggaagcc   2460

caggttcatg agtgcctggg ctcaggtgat cattgcctca attctgatta gtgtgcaact   2520

aaccctggtg gtaaccctga tcatcatgga accccctatg cccattctgt cctacccaag   2580

tatcaaggaa gtctacctta tctgcaatac cagcaacctg ggtgtggtgg cccctttggg   2640

ctacaatgga ctcctcatca tgagctgtac ctactatgcc ttcaagaccc gcaacgtgcc   2700

cgccaacttc aacgaggcca aatatatcgc gttcaccatg tacaccacct gtatcatctg   2760

gctagctttt gtgcccattt actttgggag caactacaag atcatcacaa cttgctttgc   2820

agtgagtctc agtgtaacag tggctctggg gtgcatgttc actcccaaga tgtacatcat   2880

tattgccaag cctgagagga atgtccgcag tgccttcacc acctctgatg ttgtccgcat   2940

gcatgttggc gatggcaagc tgccctgccg ctccaacact ttcctcaaca tcttccgaag   3000

aaagaaggca ggggcaggga atgccaagaa gaggcagcca gaattctcgc ccaccagcca   3060

atgtccgtcg gcacatgtgc agctttgaaa acccccacac tgcagtgaat gtttctaatg   3120

gcaagtctgt gtcatggtct gaaccaggtg gaggacaggt gcccaaggga cagcatatgt   3180

ggcaccgcct ctctgtgcac gtgaagacca atgagacggc ctgcaaccaa acagccgtca   3240

tcaagcccct cactaaaagt taccaaggct ctggcaagag cctgaccttt tcagatacca   3300

gcaccaagac cctttacaac gtagaggagg aggaggatgc ccagccgatt cgctttagcc   3360

cgcctggtag cccttccatg gtggtgcaca ggcgcgtgcc aagcgcggcg accactccgc   3420

ctctgccgtc ccacctgacc gcagaggaga cccccctctt cctggccgaa ccagccctcc   3480

ccaagggctt gccccctcct ctccagcagc agcagcaacc ccctccacag cagaaatcgc   3540

tgatggacca gctccaggga gtggtcagca acttcagtac cgcgatcccg gattttcacg   3600

cggtgctggc aggccccggt ggtcccggga acgggctgcg gtccctgtac ccgcccccgc   3660

cacctccgca gcacctgcag atgctgccgc tgcagctgag cacctttggg gaggagctgg   3720

tctccccgcc cgcggacgac gacgacgaca gcgagaggtt taagctcctc caggagtacg   3780

tgtatgagca cgagcgggaa gggaacacgg aagaagacga actggaagag gaggaggagg   3840

acctgcaggc ggccagcaaa ctgaccccgg atgattcgcc tgcgctgacg cctccgtcgc   3900

ctttccgcga ctcggtggcc tcgggcagct cggtgcccag ctcccccgtg tccgagtcgg   3960

tgctctgcac ccctcccaac gtatcctacg cctctgtcat tctgcgggac tacaagcaaa   4020

gctcttccac cctgtaaggg ggaagggtcc acatagaaaa gcaagacaag ccagagatct   4080

cccacacctc cagagatgtg caaacagctg ggaggaaaag cctgggagtg gggggcctcg   4140

tcgggaggac aggagaccgc tgctgctgct gccgctactg ctgctgctgc cttaagtagg   4200

aagagaggga aggacaccaa gcaaaaaatg ttccaggcca ggattcggat tcttgaatta   4260

ctcgaagcct tctctgggaa gaaagggaat tctgacaaag cacaattcca tatggtatgt   4320

aacttttatc acaaatcaaa tagtgacatc acaaacataa tgtcctcttt tgcacaattg   4380

tgcatagata tatatatgcc cacacacact gggccatgct tgccaaggaa cagcccacgt   4440

ggacatgcca gtcggatcat gagttcacct gatggcattc ggagtgagct ggtggagcca   4500

gacagagcag gtgcggggaa gggaagggcc caggccagac ccatcccaaa cggatgatgg   4560

gatgatggga cagcagctcc ttgctcagaa gcccttctcc ccgctgggct gacagactcc   4620

tcatcttcag gagactcagg aatggagcgg cacaggggtc tctcttcatc cactgcaacc   4680

catccagtgc cagctttgag attgcacttg aagaaaggtg catggacccc ctgctgctct   4740

gcagattccc tttatttagg aaaacaggaa taagagcaaa attatcacca aaaagtgctt   4800

catcaggcgt gctacaggag gaaggagcta gaaatagaac aatccatcag catgagactt   4860

tgaaaaaaaa acacatgatc agcttctcat gttccatatt cacttattgg cgatttgggg   4920

aaaaggccgg aacaagagat tgttacgaga gtggcagaaa cccttttgta gattgacttg   4980

tgtttgtgcc aagcgggctt tccattgacc ttcagttaaa gaacaaacca tgtgacaaaa   5040

ttgttacctt ccacttactg tagcaaataa tacctacaag ttgaacttct aagatgcgta   5100

tatgtacaat ttggtgccat tatttctcct acgtattaga gaaacaaatc catctttgaa   5160

tctaatggtg tactcatagc aactattact ggtttaaatg acaaataatt ctatcctatt   5220

gtcactgaag tccttgtaac tagcgagtga atgtgttcct gtgtccttgt atatgtgcga   5280

tcgtaaaatt tgtgcaatgt aatgtcaaat tgactggtca atgtcaacct agtagtcaat   5340

ctaactgcaa ttagaaattg tcttttgaat atactatata tattttttat gttccaataa   5400

tgttttgtac atcattgtca tcaatatcta cagaagctct ttgacggttt gaatactatg   5460

gctcaaggtt ttcatatgca gctcggatgg acatttttct tctaagatgg aacttatttt   5520

tcagatattt tctgatgtgg agatatgtta ttaatgaagt ggtttgaaaa tttgttatat   5580

taaaagtgca caaaaactga gagtgaaaat aaaaggtaca ttttataagc ttgcacacat   5640

tattaacaca taagattgaa caaagcattt agattattcc aggttatatc atttttttaa   5700

agattttcca cagctacttg agtgtctaac atacagtaac atctaactca gctaataatt   5760

tgtaaaatct ttatcaatca cattttgcct tcttttaatt tttatgttca tggactttta   5820

ttcctgtgtc ttggctgtca taacttttta tttctgctat ttgctgttgt gtaatatcca   5880

tggacatgta atccacttac tccatcttta caatcccttt ttaccaccaa taaaaggatt   5940

tttcttgctg ttttgatttc ttctattatt tgtggaatga attatacccc ccttaaatat   6000

ctttgtttat gccttatgtt cagtcatatt ttaatatgct tccttcatat tgaagctgct   6060

gatttctcag ccaaaaatca tcttagaatc tttaaatatc cattgcatca tttgttcaga   6120

atttaacatc cattccaatg ttggaggctt gtattactta tatttcatca tattctattg   6180

ccaagtttag tcagttccac accaagaatg aactgcattt cctttaaaaa ttattttaaa   6240

acacctttat tgaaaagatc tcatgactga gatgtggact ttggttccat gttttcattg   6300

taagaaagca gagagcggaa aatcaatggc tccagtgatt aatagatggg tttttagtaa   6360

ttgacaaatt catgagggaa agcatatgat ctctttatta gtgaatcatg cttatttttt   6420

actcttaatg ccactaatat acatccctaa tatcacaggg cttgtgcatt cagattttta   6480

aaaaattagg atagataagg aaacaactta tattcaagtg taagatgata tcaggttggt   6540

ctaagacttt tggtgaacac gttcattcaa ctgtgatcac tttattactc tgaatgccta   6600

ctattatcct gattatgggg tctcctgaat aaatagagta ttagtcctta tgtcatcatt   6660

gttcaaaatt ggagatgtac acatacatac cctataccaa gagggccgaa actcttcacc   6720

ttgatgtatg ttctgataca agttgttcag cttcttgtaa atgtgttttc cttcggcttg   6780

ttactgcctt ttgtcaaata atcttgacaa tgctgtataa taaatatttt ctattt       6836


<210>  3415
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  3415

Met Val Gly Leu Leu Leu Phe Phe Phe Pro Ala Ile Phe Leu Glu Val 
1               5                   10                  15


Ser Leu Leu Pro Arg Ser Pro Gly Arg Lys Val Leu Leu Ala Gly Ala 
            20                  25                  30


Ser Ser Gln Arg Ser Val Ala Arg Met Asp Gly Asp Val Ile Ile Gly 
        35                  40                  45


Ala Leu Phe Ser Val His His Gln Pro Pro Ala Glu Lys Val Pro Glu 
    50                  55                  60


Arg Lys Cys Gly Glu Ile Arg Glu Gln Tyr Gly Ile Gln Arg Val Glu 
65                  70                  75                  80


Ala Met Phe His Thr Leu Asp Lys Ile Asn Ala Asp Pro Val Leu Leu 
                85                  90                  95


Pro Asn Ile Thr Leu Gly Ser Glu Ile Arg Asp Ser Cys Trp His Ser 
            100                 105                 110


Ser Val Ala Leu Glu Gln Ser Ile Glu Phe Ile Arg Asp Ser Leu Ile 
        115                 120                 125


Ser Ile Arg Asp Glu Lys Asp Gly Ile Asn Arg Cys Leu Pro Asp Gly 
    130                 135                 140


Gln Ser Leu Pro Pro Gly Arg Thr Lys Lys Pro Ile Ala Gly Val Ile 
145                 150                 155                 160


Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn Leu Leu Gln 
                165                 170                 175


Leu Phe Asp Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser Ile Asp Leu 
            180                 185                 190


Ser Asp Lys Thr Leu Tyr Lys Tyr Phe Leu Arg Val Val Pro Ser Asp 
        195                 200                 205


Thr Leu Gln Ala Arg Ala Met Leu Asp Ile Val Lys Arg Tyr Asn Trp 
    210                 215                 220


Thr Tyr Val Ser Ala Val His Thr Glu Gly Asn Tyr Gly Glu Ser Gly 
225                 230                 235                 240


Met Asp Ala Phe Lys Glu Leu Ala Ala Gln Glu Gly Leu Cys Ile Ala 
                245                 250                 255


His Ser Asp Lys Ile Tyr Ser Asn Ala Gly Glu Lys Ser Phe Asp Arg 
            260                 265                 270


Leu Leu Arg Lys Leu Arg Glu Arg Leu Pro Lys Ala Arg Val Val Val 
        275                 280                 285


Cys Phe Cys Glu Gly Met Thr Val Arg Gly Leu Leu Ser Ala Met Arg 
    290                 295                 300


Arg Leu Gly Val Val Gly Glu Phe Ser Leu Ile Gly Ser Asp Gly Trp 
305                 310                 315                 320


Ala Asp Arg Asp Glu Val Ile Glu Gly Tyr Glu Val Glu Ala Asn Gly 
                325                 330                 335


Gly Ile Thr Ile Lys Leu Gln Ser Pro Glu Val Arg Ser Phe Asp Asp 
            340                 345                 350


Tyr Phe Leu Lys Leu Arg Leu Asp Thr Asn Thr Arg Asn Pro Trp Phe 
        355                 360                 365


Pro Glu Phe Trp Gln His Arg Phe Gln Cys Arg Leu Pro Gly His Leu 
    370                 375                 380


Leu Glu Asn Pro Asn Phe Lys Arg Ile Cys Thr Gly Asn Glu Ser Leu 
385                 390                 395                 400


Glu Glu Asn Tyr Val Gln Asp Ser Lys Met Gly Phe Val Ile Asn Ala 
                405                 410                 415


Ile Tyr Ala Met Ala His Gly Leu Gln Asn Met His His Ala Leu Cys 
            420                 425                 430


Pro Gly His Val Gly Leu Cys Asp Ala Met Lys Pro Ile Asp Gly Ser 
        435                 440                 445


Lys Leu Leu Asp Phe Leu Ile Lys Ser Ser Phe Ile Gly Val Ser Gly 
    450                 455                 460


Glu Glu Val Trp Phe Asp Glu Lys Gly Asp Ala Pro Gly Arg Tyr Asp 
465                 470                 475                 480


Ile Met Asn Leu Gln Tyr Thr Glu Ala Asn Arg Tyr Asp Tyr Val His 
                485                 490                 495


Val Gly Thr Trp His Glu Gly Val Leu Asn Ile Asp Asp Tyr Lys Ile 
            500                 505                 510


Gln Met Asn Lys Ser Gly Val Val Arg Ser Val Cys Ser Glu Pro Cys 
        515                 520                 525


Leu Lys Gly Gln Ile Lys Val Ile Arg Lys Gly Glu Val Ser Cys Cys 
    530                 535                 540


Trp Ile Cys Thr Ala Cys Lys Glu Asn Glu Tyr Val Gln Asp Glu Phe 
545                 550                 555                 560


Thr Cys Lys Ala Cys Asp Leu Gly Trp Trp Pro Asn Ala Asp Leu Thr 
                565                 570                 575


Gly Cys Glu Pro Ile Pro Val Arg Tyr Leu Glu Trp Ser Asn Ile Glu 
            580                 585                 590


Ser Ile Ile Ala Ile Ala Phe Ser Cys Leu Gly Ile Leu Val Thr Leu 
        595                 600                 605


Phe Val Thr Leu Ile Phe Val Leu Tyr Arg Asp Thr Pro Val Val Lys 
    610                 615                 620


Ser Ser Ser Arg Glu Leu Cys Tyr Ile Ile Leu Ala Gly Ile Phe Leu 
625                 630                 635                 640


Gly Tyr Val Cys Pro Phe Thr Leu Ile Ala Lys Pro Thr Thr Thr Ser 
                645                 650                 655


Cys Tyr Leu Gln Arg Leu Leu Val Gly Leu Ser Ser Ala Met Cys Tyr 
            660                 665                 670


Ser Ala Leu Val Thr Lys Thr Asn Arg Ile Ala Arg Ile Leu Ala Gly 
        675                 680                 685


Ser Lys Lys Lys Ile Cys Thr Arg Lys Pro Arg Phe Met Ser Ala Trp 
    690                 695                 700


Ala Gln Val Ile Ile Ala Ser Ile Leu Ile Ser Val Gln Leu Thr Leu 
705                 710                 715                 720


Val Val Thr Leu Ile Ile Met Glu Pro Pro Met Pro Ile Leu Ser Tyr 
                725                 730                 735


Pro Ser Ile Lys Glu Val Tyr Leu Ile Cys Asn Thr Ser Asn Leu Gly 
            740                 745                 750


Val Val Ala Pro Leu Gly Tyr Asn Gly Leu Leu Ile Met Ser Cys Thr 
        755                 760                 765


Tyr Tyr Ala Phe Lys Thr Arg Asn Val Pro Ala Asn Phe Asn Glu Ala 
    770                 775                 780


Lys Tyr Ile Ala Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala 
785                 790                 795                 800


Phe Val Pro Ile Tyr Phe Gly Ser Asn Tyr Lys Ile Ile Thr Thr Cys 
                805                 810                 815


Phe Ala Val Ser Leu Ser Val Thr Val Ala Leu Gly Cys Met Phe Thr 
            820                 825                 830


Pro Lys Met Tyr Ile Ile Ile Ala Lys Pro Glu Arg Asn Val Arg Ser 
        835                 840                 845


Ala Phe Thr Thr Ser Asp Val Val Arg Met His Val Gly Asp Gly Lys 
    850                 855                 860


Leu Pro Cys Arg Ser Asn Thr Phe Leu Asn Ile Phe Arg Arg Lys Lys 
865                 870                 875                 880


Ala Gly Ala Gly Asn Ala Lys Lys Arg Gln Pro Glu Phe Ser Pro Thr 
                885                 890                 895


Ser Gln Cys Pro Ser Ala His Val Gln Leu 
            900                 905


<210>  3416
<211>  27481
<212>  DNA
<213>  Homo sapiens

<400>  3416
agtgtgggcg agccagccag ggtgagcgcg ggcgccgggc cgcggccgcc ggccgcagcg     60

ggctgagatt gttgtcctct gtcaccaggg cggctgggct cccgcagtcc tgcagaccgc    120

gcccgatccc ggcgacaggg cgggcggaca gccgcgcatc cccggggtcc cgccgagcct    180

gggcgcagag agccgggagg aagcgttcgc tcgcttcgcc ttgctgctgg gaaactgaac    240

gaggccgaga gagaaggttc ttgagttcat gtaagaggac agtcttaaaa cggaagaaga    300

aaaagaagca gttcagtctt tgggagagct gcctccttgt tgagtgctgc aaaggcctgg    360

aattcattta tgacagaata gatctagaaa agtccaagca tgttttctag agtggtgtag    420

ccctgtgctg cctccagtga agagtctctt ggtgttggct tcgtgcttcc ggagggacca    480

tggcaacctc cagaggggcc tcccggtgtc ctcgggatat cgccaatgtg atgcagaggc    540

tgcaagatga gcaagagata gtacaaaaac gaactttcac aaaatggatc aactctcatc    600

tggccaagcg gaaacctcca atggtggtgg acgatctttt tgaagacatg aaagatggtg    660

ttaaactgct tgcccttctg gaggtcctgt ctgggcagaa actgccttgt gaacaaggac    720

gccggatgaa gcgaatccat gctgtggcta acattggcac ggcactcaag ttcctcgaag    780

gaagaaagtc catgcacaga ggatcaccga ttaaattagt caacattaac tccaccgata    840

tagctgatgg ccgaccctca atagttcttg gattgatgtg gaccattatt ctatatttcc    900

agattgaaga gttgaccagc aacctgcccc agctccagtc tttgtccagc agcgcatcct    960

ccgtggacag catagttagc tctgagactc ccagcccacc aagtaaacgg aaggtgacca   1020

ccaagatcca aggaaatgct aagaaggctt tattaaagtg ggttcagtac acagctggca   1080

agcagactgg aatagaagta aaagattttg ggaagagttg gagaagcggg gttgcctttc   1140

attcagttat tcatgccatt cgaccggaat tggtggactt ggagacagtg aaaggcagat   1200

ccaaccgaga aaatttggag gatgctttca ctatcgccga aacagaactg gggatcccaa   1260

gactgctaga tcctgaagac gttgatgtgg ataaaccaga tgagaaatct attatgacct   1320

atgtagccca gtttctgaaa cattatcctg acatccacaa tgcaagcact gatgggcaag   1380

aggatgatga aatacttcca ggtttcccat cttttgcaaa ttctgtacaa aattttaaga   1440

gagaagacag agtaattttt aaggaaatga aagtttggat agaacaattt gagagagatt   1500

tgacaagagc acagatggtg gaatcaaatt tacaggataa atatcagtca tttaagcact   1560

tcagagttca atatgaaatg aagaggaaac agattgaaca tttaatacaa ccattacaca   1620

gagacggtaa attgtcactt gaccaagcat tggtaaaaca atcttgggat agagtgacct   1680

ccaggctctt tgactggcat atacagcttg ataaatctct tcctgcacct ctgggcacca   1740

taggtgcctg gctgtacaga gcggaggtgg ccctgagaga ggaaataacc gttcaacagg   1800

tccacgagga aacagcaaac acgatacaac ggaaacttga gcaacataag gatctgcttc   1860

aaaacacgga tgcccacaaa agagcattcc atgaaatcta ccggaccagg tctgttaacg   1920

ggattccagt gccacctgat caattagagg acatggccga gaggtttcat tttgtttcct   1980

ccacatcaga gctacaccta atgaaaatgg aatttttaga attaaagtac cgtctgctct   2040

cactgctggt tcttgcagag tcaaagctga agtcttggat cattaagtac gggaggagag   2100

agtcagtgga gcagcttcta caaaactacg tgtcttttat agaaaatagc aagttctttg   2160

aacaatatga ggtgacatac cagatcttga aacagacagc tgagatgtat gtcaaagcag   2220

atggttcagt ggaagaagct gagaatgtga tgaaattcat gaatgaaacc accgctcagt   2280

ggaggaatct ctcagtagaa gtgaggagtg tgaggagcat gctggaagaa gtgatctcta   2340

actgggatcg ctatggcaat acagtggcta gtctgcaagc ctggctagag gatgctgaaa   2400

aaatgctcaa tcaatcagaa aatgccaaaa aggatttttt tcgaaattta cctcattgga   2460

ttcagcagca tactgccatg aacgatgctg gcaattttct aattgaaacc tgtgatgaga   2520

tggtttcccg tgacctgaag cagcaattac tgttgctaaa tgggcggtgg agggagttgt   2580

ttatggaagt caagcaatat gctcaagctg atgagatgga cagaatgaag aaggaataca   2640

cagactgtgt tgttaccctg tctgcttttg caacggaagc ccataagaaa ctttctgaac   2700

ccttagaagt ctcttttatg aatgtcaagc tattaattca agacttggag gatattgagc   2760

agagggtgcc tgtgatggat gcccaataca agataattac aaagacagca cacctcatta   2820

ccaaagaaag cccccaagaa gaaggaaaag aaatgtttgc gaccatgtca aagctcaaag   2880

agcagctaac caaggtcaaa gaatgttact ccccactcct ttatgagtct cagcagctgt   2940

tgattccgtt ggaggaatta gaaaagcaga tgacgtcctt ttatgactca cttgggaaaa   3000

tcaatgaaat tatcacagtt cttgagcgtg aggcacaatc gagtgccctt tttaaacaaa   3060

aacatcagga actgttagct tgtcaagaaa actgtaagaa aaccttgaca cttattgaga   3120

aaggcagtca aagtgttcaa aagtttgtga ccttgagcaa cgtgttaaag cattttgatc   3180

agacgaggct acaaagacag attgcagata ttcatgttgc ttttcagagt atggtaaaga   3240

aaactggaga ttggaagaag catgtggaaa ccaacagtcg cttgatgaag aagtttgagg   3300

agtctcgagc agagttggag aaggtactgc ggattgctca ggagggcctg gaggaaaagg   3360

gggatccaga ggagctcctg cggagacaca ctgagttttt cagtcagctg gatcagaggg   3420

tgctcaatgc tttcctgaaa gcttgtgatg aactcaccga catccttcca gagcaggagc   3480

agcaggggct gcaggaagct gttcgaaagc tccacaaaca atggaaggat cttcaaggag   3540

aagcccctta tcatttgctt catctgaaga ttgatgtgga gaagaatagg ttcttagcct   3600

ctgtagaaga atgcagaact gagctggatc gagagaccaa gctgatgccc caggaaggca   3660

gtgaaaagat aattaaagag cacagggttt tcttcagtga caaaggtcct catcatctct   3720

gtgagaaaag gttacagctc atcgaggaac tctgtgtgaa actcccagtg cgggacccag   3780

taagggacac acctggaacc tgtcacgtga ctctcaaaga gctcagagct gccattgaca   3840

gcacctacag gaagctcatg gaagacccag acaagtggaa ggactacact agcagattct   3900

ctgagttctc atcttggata tctacaaatg agacacaatt aaaggggatc aagggtgagg   3960

ccatcgatac tgccaaccac ggagaggtta aacgtgccgt tgaagagatc agaaatggtg   4020

ttaccaaaag gggtgagacc ctcagctggc tgaaatccag gctgaaagtt ttgacagaag   4080

tttcttctga gaatgaagcc caaaagcagg gagatgagct ggcaaaatta tccagctctt   4140

tcaaggctct tgtgacgctg ctgtcagagg ttgaaaagat gctaagcaat tttggggact   4200

gtgtccagta caaagaaata gtcaaaaatt ctctcgaaga attaatttct ggctctaaag   4260

aagtccagga acaagctgag aagatcttgg atactgaaaa tctgtttgaa gcacagcagt   4320

tacttcttca tcaccagcaa aagacaaagc ggatctcagc aaagaagaga gatgtgcagc   4380

agcagatcgc gcaggcgcag cagggagaag gggggctgcc tgaccgaggc cacgaggagc   4440

tgcggaagct ggagagcaca ctggatggcc tggagcgcag ccgggagagg caggaacgcc   4500

gcatccaggt cacattaaga aaatgggagc gatttgaaac aaacaaagaa acagtagtaa   4560

gatacctttt tcaaacaggt tccagtcatg aacgcttctt gagttttagc agtttggaaa   4620

gtttatcttc agaactggaa caaacaaagg agttttctaa acggacagaa agtattgcag   4680

tccaggctga gaaccttgta aaggaagctt cagagatacc gcttgggccc caaaataagc   4740

agctgcttca acagcaggcc aagtcaatca aagaacaagt caaaaaatta gaagacacgc   4800

ttgaagaaga tattaaaacc atggaaatgg tgaaaaccaa gtgggatcat tttggcagta   4860

attttgagac tctgtccgtc tggataactg agaaagaaaa agaactcaat gccttggaaa   4920

cttcgtcatc tgccatggac atgcaaatca gccaaattaa ggtcacaatt caggaaatag   4980

aaagtaagct cagcagcatt gtaggattag aagaagaagc ccagtctttt gctcagtttg   5040

ttaccactgg agaatctgct cgaattaaag ccaagttgac acaaataaga agatacgggg   5100

aagagcttcg agagcatgca cagtgtctgg aaggaacaat cctgggacat ttatctcagc   5160

agcaaaagtt tgaagagaac cttagaaaga tccagcaatc tgtgtctgaa tttgaagata   5220

aacttgctgt tccaattaaa atatgttctt cagctacaga aacatacaaa gttcttcaag   5280

aacatatgga tctctgccag gccctggagt cactgagcag cgcgatcact gccttctcag   5340

ccagtgccag gaaggttgtg aacagagatt cctgtgttca ggaggctgcg gctctacagc   5400

agcaatacga ggacatccta aggagggcga aggagagaca gacggcgctg gagaatctgc   5460

tggcccactg gcagaggcta gagaaagaac tatcatcctt tttgacctgg ttagagcggg   5520

gtgaagctaa agccagttcc ccagaaatgg acatttctgc agacagagtc aaagtggaag   5580

gtgaacttca gttaatacag gcactgcaaa atgaagttgt atcccaggcc tcattctata   5640

gcaaactttt gcaattgaag gaatcattgt tctcagtagc ctccaaagat gatgtgaaaa   5700

tgatgaaact acatttggag cagttggatg agagatggag agatttacca cagatcatta   5760

acaaaaggat taattttctt cagtctgtgg ttgctgaaca ccagcaattt gatgagctgc   5820

tgctttcctt ttctgtctgg attaaactgt ttctcagtga attacaaact acctctgaga   5880

ttagcataat ggaccatcaa gtagccctta ctcggcataa ggaccacgca gcagaagtag   5940

agagcaaaaa gggcgaattg cagagtctgc agggtcactt agcaaagttg ggttctctgg   6000

gccgtgctga ggacctccac ctcctgcagg gaaaggctga ggactgcttc cagctgtttg   6060

aggaggccag ccaggttgtg gagaggcggc agcttgccct gtcccatttg gcagaattcc   6120

tccagagcca tgcctctctg tccggcattc tccgccagct gaggcaaaca gtggaagcaa   6180

ccaacagtat gaataagaac gagtctgatt tgatagaaaa ggacctcaat gatgctcttc   6240

aaaatgctaa agcattagaa tctgctgccg tcagtctgga tggcattctt tccaaagccc   6300

aataccatct gaaaatcggg agctctgagc aaaggacttc ctgcagagcc acggctgatc   6360

agctctgtgg agaggtagag aggatccaga accttctggg aaccaagcag agtgaggcag   6420

atgctctggc agtgttgaaa aaagcattcc aagaccagaa agaggagctt ctgaaaagca   6480

ttgaggacat tgaagaaagg actgacaaag agcgattgaa agaacctacc cgccaagctc   6540

ttcagcagag gttaagagtg tttaatcagc tagaagatga attgaattct cacgagcatg   6600

aactatgttg gttgaaagac aaagccaagc aaattgccca gaaagatgta gcttttgcac   6660

ctgaagttga cagggagata aaccgcttag aggtcacctg ggatgatacc aaaagactaa   6720

ttcatgaaaa tcagggtcag tgctgtggac ttattgactt aatgagagaa tatcagaacc   6780

tgaaatcagc tgtatctaaa gtcttagaaa atgccagcag tgtgattgta accagaacta   6840

ccataaaaga tcaggaggat cttaaatggg ctttttccaa gcatgaaact gccaagaaca   6900

aaatgaatta caaacagaaa gacttggata actttaccag caaaggaaaa cacttgttat   6960

ctgagctgaa gaaaattcac agtagtgatt tcagcttggt gaaaacagac atggagagca   7020

ccgtggacaa atggctggat gtatcagaga aacttgaaga aaacatggat aggctgagag   7080

taagcctgtc catttgggat gatgtactgt caactagaga tgagattgag ggatggtcaa   7140

acaactgcgt tccacagatg gcagaaaaca tcagcaacct ggataaccac ctcagagctg   7200

aagaactgct taaagaattt gagtctgaag ttaaaaacaa agcattgaga ttggaagaac   7260

tgcattccaa agttaatgat ctgaaagaat taactaaaaa tctagaaaca ccgccagacc   7320

ttcagtttat agaagcagac ttaatgcaga aactggagca tgccaaagaa ataactgaag   7380

tagcaaaagg aaccctgaag gatttcacgg ctcaaagtac acaagtggag aagtttatta   7440

atgacataac aacatggttc acaaaagtgg aagaatcgtt gatgaactgt gcccaaaatg   7500

agacttgtga agcattgaaa aaagtcaagg atatacaaaa agaacttcaa agtcaacaaa   7560

gcaacatcag ctctacccaa gaaaatctca atagcttgtg ccgcaagtac cactcagctg   7620

agttggagag cctgggccgt gcaatgactg gtctgataaa gaaacatgaa gccgtgagcc   7680

agttgtgctc caaaacccag gccagcctgc aggaatctct ggaaaaacac ttcagtgagt   7740

ctatgcagga attccaagaa tggtttttgg gagcaaaggc agcagcaaaa gaatcatcag   7800

atcgcaccgg tgacagcaaa gttctagaag caaagctcca tgatcttcag aacattttgg   7860

actcagtcag tgatgggcag agcaaacttg atgcagtgac tcaagaagga caaactttgt   7920

atgcacattt gtctaaacaa attgtcagta gcattcaaga acaaatcaca aaggccaatg   7980

aagagtttca agcatttctg aaacaatgcc ttaaagataa gcaggctctt caagactgtg   8040

cttcagaact tggaagcttt gaagatcagc acagaaaact gaacttatgg atccatgaaa   8100

tggaagaaag gttcaatacg gaaaacttgg gagagagtaa acagcacatt cctgagaaga   8160

aaaatgaagt tcataaagtt gaaatgtttt tgggagaact gctggctgca agagagtctc   8220

ttgataagct ttcccagaga gggcagcttc tgagtgaaga aggccacggt gctgggcagg   8280

agggccgcct gtgttcccag ctcctcacaa gccaccagaa cctacttaga atgaccaaag   8340

agaaactccg gagctgccag gtggcccttc aggagcacga agccctggag gaagcactgc   8400

aaagcatgtg gttctgggtg aaggccattc aggacagact ggcctgtgca gagagcactc   8460

ttgggagcaa agacaccctg gagaaacggc tgtcacaaat acaggatatt ctcctgatga   8520

aaggtgaagg ggaagttaag ttgaatatgg ccattggcaa gggggaacag gccttgagaa   8580

gtagcaacaa agaaggtcag agggtgattc agactcagtt agagaccctt aaagaagtgt   8640

gggctgacat catgagctcc tccgtccacg ctcaaagcac tttagagtct gtgattagcc   8700

aatggaatga ctatgtagag aggaaaaacc agttggagca gtggatggaa tcagtggatc   8760

aaaaaataga acatccctta caaccacagc caggtctgaa agagaagttc gtcctgcttg   8820

accacctcca gtccatcctg tctgaggcag aagatcacac gagagccctt caccgtctaa   8880

ttgcgaagtc cagggagctc tacgaaaaga cagaggatga gtctttcaag gacacagctc   8940

aagaggagct gaaaacacag tttaatgata taatgactgt tgccaaggaa aaaatgagga   9000

aagtggaaga gattgtgaaa gatcatctaa tgtatttaga tgcggtccac gagttcacag   9060

attggctcca ttcagcaaag gaagaacttc accggtggtc agatatgtct ggagattcat   9120

cagccaccca gaaaaagtta tcaaaaatta aggagctgat agattccaga gagattggtg   9180

caagccgtct cagcagagtg gagtcgctgg ctcccgaagt gaaacagaac acaactgcca   9240

gtgggtgtga gctcatgcac acggagatgc aggccctgcg tgccgactgg aagcagtggg   9300

aagacagtgt attccaaacg cagagctgtt tggagaacct ggtcagccag atggcccttt   9360

cggagcagga attctcaggc caagtggctc aactggagca ggccctggaa cagttcagtg   9420

cccttctgaa aacctgggct cagcagttaa ccctcctgga aggcaagaac acggatgagg   9480

agatagtgga atgctggcac aaaggacaag agatactgga tgctttgcaa aaagcagagc   9540

ctagaacaga ggatctcaag tctcagctga atgaactttg tcgattttcc agagacctga   9600

gtacctacag tggaaaagtt tctggcttga ttaaagagta taattgtctt tgtttgcaag   9660

catccaaggg ctgccagaat aaagaacaga ttttacagca aagatttcga aaggccttca   9720

gggatttcca gcagtggttg gttaatgcaa aaatcactac cgccaagtgt tttgatatac   9780

ctcaaaatat aagtgaagtt tcaactagtc ttcagaaaat acaggagttt ttgtcagaaa   9840

gtgaaaatgg acagcacaag ctaaacatga tgctgtctaa aggggaactt ctgagtaccc   9900

tgctgaccaa agagaaagcg aaagggatcc aggccaaagt tacagctgca aaagaagatt   9960

ggaaaaattt tcattcaaat ctccaccaaa aagaatctgc tctagagaat ctaaagatcc  10020

aaatgaagga ctttgaagta agtgctgagc ctatccagga ctggctgagt aaaactgaga  10080

agatggtcca tgaaagcagc aatcgcctct atgatctgcc agcaaagagg agggagcagc  10140

agaagctcca gtctgtcctt gaggaaatac actgctacga gcctcagctc aacaggctga  10200

aagagaaagc tcagcagctg tgggaaggac aagctgccag caagagcttt aggcacagag  10260

tgtcgcagct gtcttctcag tatctagcgc taagcaattt aacaaaggag aaagtgtcaa  10320

gactggatag aatcgttgca gaacacaatc agttctctct tgggattaaa gaattacaag  10380

actggatgac ggatgcgatt cacatgctgg attcatactg ccacccgaca tccgacaaaa  10440

gtgtgctgga cagcaggacg ctcaagctcg aggctctatt atcagtcaaa caggaaaaag  10500

agattcagat gaaaatgata gtgaccaggg gagaatctgt ccttcagaat acttctccag  10560

aaggcattcc cactattcag cagcagctgc agagtgtgaa ggatatgtgg gcatcccttt  10620

tgtctgcagg gattcgttgt aaaagccaac tcgaaggagc tctctccaag tggacaagtt  10680

atcaggatgg cgttcgacag ttctccggtt ggatggatag tatggaagcc aacctgaatg  10740

aatcagaaag gcagcatgcg gagctgcggg ataaaacaac gatgctcgga aaagccaagt  10800

tattaaatga agaagtgctg agttacagca gcttgctgga gaccatcgaa gtcaaagggg  10860

ctggcatgac agaacactat gtcacccagc tagaactcca ggatctacag gaacgataca  10920

gagccatcca agagagggcc aaggaagccg taaccaagtc tgaaaaactt gtccgcctgc  10980

accaagagta tcagagagac ctaaaggcat ttgaagtttg gttggggcaa gaacaagaaa  11040

agctcgacca gtattcagtt cttgaaggtg atgcccacac tcatgagaca acattgcgtg  11100

atcttcagga gctacaggta cactgtgcag aggggcaggc cctgttgaac tcagtgctgc  11160

acaccagaga ggatgtgatc ccatcaggta tcccacaggc agaggaccgg gctttagagt  11220

ctctccggca agactggcag gcttaccagc acaggctgtc cgagactcga actcagttca  11280

ataacgtggt gaacaaattg aggctaatgg agcaaaagtt tcagcaagta gatgaatggc  11340

tcaaaacagc agaggagaaa aagtggcacg aagaagtgac tgcatacaga gatgaagttg  11400

aggaagtggg agctagagct caggagatac tggacgagag ccacgtgaac agcagaatgg  11460

gttgccaggc cacccagctg acttccagat accaggccct gcttctccaa gtgctggaac  11520

aaataaaatt cctggaggag gagattcaga gtttggagga atcagaatca tccctcagtt  11580

cctattctga ttggtatggc tctactcata aaaacttcaa gaatgtggct accaagattg  11640

acaaagtaga tacagtaatg atggggaaga aattgaagac gttggaggtt ttgctcaaag  11700

acatggagaa aggtcacagt ttgctgaaat cagcccggga gaaaggagag agggctgtta  11760

aatacttgga ggaaggcgag gcagagaggt taagaaagga gattcatgat cacatggagc  11820

agttgaagga actgaccagc actgtccgga aagaacacat gacgctggaa aaaggtcttc  11880

atttagcaaa ggaattctca gataaatgca aagcactgac acagtggata gcagaatacc  11940

aggaaattct acatgttcct gaagaaccca aaatggaatt atatgagaaa aaagctcagt  12000

tatctaaata caagtcactt caacaaacgg tgctgtccca tgaaccatca gtaaagtcag  12060

tgagagagaa gggtgaagct cttttggaac tggtgcagga cgtcacttta aaggacaaaa  12120

tagatcaact tcaaagtgat taccaggacc tgtgcagcat aggaaaggca atgatggaag  12180

aaattgctgg ttttgaagac cgtttgaaca atcttcaaat gaaaggtgat actttgattg  12240

gccaatgtgc agaccacctg caagcgaaac ttaaacaaaa cgtgcatgct catctgcagg  12300

gcacaaagga cagctactca gcgatctgca gcacagctca gaggatgtac cagagtttgg  12360

aacacgaact tcagaagcac gtcagccgac aagacaccct gcagcagtgc caggcctggc  12420

tttctgcagt ccagccggat ttagagccaa gtcctcaacc acctcttagt agggcagaag  12480

ccattaagca ggtcaaacac ttcagagctt tgcaagagca ggcaaggacc tacctagatc  12540

tcctttgctc catgtgtgac ctgtcaaatg cttcggtgaa aaccacagca aaagacattc  12600

aacaaacaga gcaaacgatt gaacaaaagc ttgtccaggc ccagaactta actcagggct  12660

gggaagagat caagcacctg aagtctgagc tctggattta cctgcaagat gctgatcagc  12720

aactgcagaa catgaagagg aggcactctg agctggagct gaacattgca cagaacatgg  12780

tttcacaagt taaggatttt gttaagaaac tacagagcaa acaggcatcc gtgaacacca  12840

taatagaaaa ggtgaataag ttaacaaaga aggaggaatc gcctgaacac aaggaaataa  12900

atcatttaaa tgatcagtgg ctcgatttgt gccgtcagtc taacaacctg tgcttgcaaa  12960

gggaagagga tcttcagaga acaagagatt accatgactg tatgaatgtt gttgaagtgt  13020

tcctagaaaa atttactaca gaatgggata acttggccag atctgatgca gagagtacag  13080

ctgtccacct ggaagctttg aaaaagttag cattggcatt gcaggagaga aagtatgcta  13140

ttgaagatct gaaagatcaa aagcagaaaa tgatagagca tctgaattta gatgacaagg  13200

agttagtcaa agaacagacg agtcatttag agcaacgttg gtttcagctt gaggacctca  13260

ttaaaaggaa aatccaagtg tcagtcacca acttggagga gttaaatgtg gtgcagtcca  13320

gatttcagga gctaatggag tgggcagaag agcaacaacc caacatcgcc gaggccctta  13380

agcagagccc tcctccagat atggctcaga accttctcat ggatcacctg gccatctgca  13440

gtgaactgga ggccaagcag atgctcctga aatcgcttat aaaggacgca gacagggtca  13500

tggcagatct tggtctcaat gagcgacagg tcatccagaa ggctctctct gatgcacaaa  13560

gccacgtgaa ttgtctcagt gacttagtgg gccagcgaag aaagtactta aacaaagcct  13620

tgtccgagaa aacccagttt ctcatggcag tgttccaggc caccagccaa attcagcaac  13680

atgagcgaaa gataatgttc cgtgaacaca tctgtctgtt accagatgat gtgagcaaac  13740

aagtcaaaac atgtaagagt gcacaagcca gcctcaagac ttaccaaaat gaagtcactg  13800

gactttgggc ccagggtcgc gaactaatga aggaagtcac agagcaggaa aagagtgaag  13860

tgctggggaa gcttcaggaa ttgcagagtg tctatgacag tgttttacaa aagtgcagtc  13920

accggttaca agaactagag aagaatttgg tttctaggaa gcattttaag gaagattttg  13980

ataaagcttg ccactggcta aaacaagcag atattgttac atttcctgaa atcaacctaa  14040

tgaatgagag ttctgagctt catacacaac tggctaaata ccaaaacatt cttgaacaat  14100

ctccagaata tgaaaatctt ctacttacgc tgcagagaac tgggcagacc atattaccat  14160

cgctgaatga agtcgatcat tcctacctca gtgaaaagct aaatgctttg cctcgacaat  14220

ttaatgtaat tgttgccttg gctaaagaca agttctataa agtccaggaa gcaattcttg  14280

ctcggaagga atatgcttcc ttgattgagt tgacaaccca gtctctgagt gaacttgaag  14340

cccaattctt gaggatgagc aaagttccca ccgacctggc cgttgaggag gctctttctc  14400

tgcaagatgg ttgcagagcc attctggacg aggtggcggg ccttggggag gcggtggatg  14460

aactgaacca gaaaaaagaa ggttttcgca gcacaggtca gccttggcag ccagacaaga  14520

tgctgcacct tgtcacctta tatcacaggc tgaagcgaca aacagaacag agggttagct  14580

tattagaaga caccaccagt gcttaccaag aacacgagaa gatgtgccaa cagctggaga  14640

gacaactgaa gtctgtaaaa gaggagcagt ccaaagtgaa tgaggaaacg ctgcctgcag  14700

aggagaagct caaaatgtat cactccctgg caggaagtct ccaggactca gggattgtac  14760

tgaaacgagt aaccatacat cttgaagatc ttgccccaca ccttgacccc ttggcttatg  14820

agaaagccag gcatcagatc cagtcctggc aaggggagtt aaaactgttg acttctgcca  14880

ttggtgagac ggtgacagaa tgtgagagcc gaatggtgca gagtatagac ttccagactg  14940

agatgagtcg ctccctggac tggctgagga gagtgaaggc agagctcagt gggccggtgt  15000

acctagacct caacctgcag gacatccaag aggaaatcag aaaaatccaa attcatcagg  15060

aagaggtcca gtccagcttg agaatcatga atgcgctgag tcacaaggaa aaggagaagt  15120

tcacaaaggc caaggagctg atttctgcgg atttagaaca cagcctcgct gagctctcag  15180

agctggatgg agacatccag gaagccttac gcaccagaca ggctaccttg actgaaatat  15240

atagccagtg tcaaaggtat tatcaggtat ttcaagcagc caatgactgg cttgaggatg  15300

cccaagaatt gttacagctg gcaggcaatg gcctagacgt ggagagcgca gaggaaaatc  15360

tcaaaagcca catggaattt ttcagtacag aggatcagtt ccatagtaac ctggaggagc  15420

tccacagcct ggtagccacc ctggacccac tcatcaagcc aaccggcaaa gaagacctag  15480

aacagaaagt ggcttctctg gaactcagga gccagaggat gagccgggac tctggtgccc  15540

aagtggatct cttgcagaga tgcacagctc aatggcacga ttaccagaaa gcaagggaag  15600

aggttattga attgatgaat gatacagaaa agaaattgtc tgagttttct ttgttgaaga  15660

cttcgtctag tcatgaagcg gaagaaaaat tgtcagaaca caaggcttta gtgtcagtgg  15720

ttaactcttt ccatgagaaa attgtggccc ttgaggaaaa agcttcacaa ctggagaaaa  15780

ccggaaatga tgccagcaaa gccaccctga gcaggtcaat gaccaccgtc tggcagcgct  15840

ggacacgcct tcgagctgtg gcccaggacc aggagaagat cctggaagat gcagtggatg  15900

agtggacggg ctttaacaac aaggttaaaa aggccactga aatgattgat cagctgcaag  15960

ataagttacc tggaagttca gcagagaaag catcgaaagc agagctctta actcttcttg  16020

aataccacga cacgttcgtt ctggagctgg agcagcagca gtcggccttg ggcatgctgc  16080

ggcagcaaac cctgagcatg ctccaggatg gagccgcccc aacccctggg gaagagcctc  16140

cgctcatgca ggaaatcacc gccatgcaag atcggtgcct gaacatgcag gagaaagtga  16200

agactaatgg aaagttggtg aagcaagagc tgaaggaccg agaaatggtg gagactcaga  16260

tcaattctgt gaaatgttgg gttcaggaaa cgaaagaata tttagggaat ccaacaatag  16320

aaatagatgc tcaacttgaa gaacttcaga ttctcctaac agaagccaca aatcaccgac  16380

agaacattga aaaaatggca gaagaacaga aggagaagta cttaggtctt tataccatat  16440

taccttctga actctccctt cagttggctg aagtggcgtt agatctaaag atccgagatc  16500

agatccaaga caaaataaaa gaagttgagc agagcaaggc cacgagccag gaactcagcc  16560

ggcaaattca gaagttagct aaagacctca caactattct aactaagctg aaagcgaaga  16620

cagataatgt agttcaagct aaaactgacc aaaaggtgct gggagaggaa ttagatggct  16680

gtaattcaaa gttaatggaa ttagatgcag cagtacagaa attcttggaa cagaatggcc  16740

aactgggtaa gccactggcc aagaagatag gaaaactgac tgaacttcac cagcagacca  16800

ttagacaagc tgagaatcgg ctctccaagc tcaatcaggc agcatcacat ttagaagaat  16860

acaatgaaat gcttgaatta attttgaagt ggattgaaaa agctaaagtc ttggctcatg  16920

gaactattgc atggaattct gcaagccagc ttcgggaaca atatattttg catcagaccc  16980

tgctagaaga atccaaagaa attgacagtg agctggaagc aatgactgag aaattacagt  17040

acctcactag cgtgtactgt acagaaaaaa tgtctcagca agtggcagaa ctgggacggg  17100

agactgagga gttgcgacag atgatcaaaa ttcgtttgca gaacctccaa gatgcagcta  17160

aggatatgaa aaaatttgaa gcagagttga aaaagttaca agctgccttg gagcaagccc  17220

aggcaacact gacttctcca gaagttggac gtctcagtct caaggagcag ctctctcatc  17280

ggcagcattt gttgtctgag atggagtcac tgaagccgaa ggtgcaagca gtgcagctct  17340

gccagagtgc cctccggatc cccgaggatg tggttgccag cttacctctc tgtcatgctg  17400

ctctgcggct gcaggaagag gccagccggc tgcagcacac cgccatccag cagtgtaaca  17460

tcatgcaggc agctgtggta caatatgaac aatatgagca agaaatgaaa catctccagc  17520

aactgataga aggagctcac agagagattg aggataaacc tgttgccacc agtaacatac  17580

aggagctgca ggctcagatt tctcggcatg aggagctggc gcagaaaatt aagggctacc  17640

aggagcagat cgcttctttg aattccaagt gcaagatgct gacgatgaaa gccaagcacg  17700

ccaccatgct gctgacggtg accgaggtcg aggggctggc ggaagggaca gaggacctgg  17760

atggggagct cctccccacg ccttcggccc acccctctgt ggtcatgatg actgcaggtc  17820

gctgtcacac tttgctgtca ccggtcactg aggagtctgg ggaggaggga accaacagtg  17880

agatttcctc tccacctgcc tgtcgctccc cttcacctgt ggctaataca gatgcttctg  17940

ttaaccagga cattgcatat taccaagcct tgtctgctga gaggttgcag acagatgctg  18000

caaaaattca ccccagcaca tccgcatccc aggagttcta tgaaccggga ttggagccat  18060

ccgctactgc caaactgggt gatttgcagc gttcttggga aaccttaaag aatgtgatca  18120

gtgagaagca gcgcacactc tatgaagctt tggaacgcca gcagaagtac caggactccc  18180

tccagtccat ctctacgaag atggaggcca ttgagctgaa actcagtgag agcccagagc  18240

ctggcaggag tccagaaagc cagatggctg aacatcaggc attgatggat gagattctca  18300

tgctccagga tgaaatcaat gagctccagt cctctctcgc agaggagctg gtatccgagt  18360

cttgtgaggc cgaccctgcg gagcagctgg ccttgcagtc cacgctcact gtcttagccg  18420

agcgaatgtc caccatcagg atgaaagcct cggggaaacg gcagcttttg gaggagaagt  18480

tgaatgatca gctggaggaa caaaggcagg aacaggccct gcagaggtat cgctgtgaag  18540

ccgatgagct ggacagctgg ctcttgagta ccaaggccac tctggacact gcgctgagtc  18600

cacccaagga gcccatggac atggaggccc agcttatgga ctgccagaat atgctggtgg  18660

aaatagagca gaaggtggtg gctttatcag aactgtcagt ccacaatgag aacctgctgc  18720

tggagggcaa agctcacacc aaggacgagg ccgagcagct ggctggaaag ctgagaaggc  18780

tcaaggggag cctgctggag ctgcagagag ccctgcatga taagcagctc aacatgcagg  18840

gaacagcaca ggagaaggag gagagcgatg ttgacctaac agccacgcag agccccggcg  18900

tccaggaatg gctggcccaa gctcgcacca catggaccca gcagcggcag agcagtctcc  18960

agcaacaaaa agagttagaa caggaattag ccgagcagaa gagtctcctt cgctcagtag  19020

ccagtcgtgg agaggagatt ctaattcaac attcggcggc agagacctct ggtgatgctg  19080

gcgaaaaacc tgatgtgtta tcccaggagt tggggatgga aggggagaaa tcatccgctg  19140

aagaccagat gagaatgaaa tgggaaagcc tacatcaaga atttagtacc aagcagaaac  19200

tactacagaa tgttctggaa caggaacaag agcaagtgct ttatagcagg ccaaatcgac  19260

tcttgtctgg tgtgccactg tacaaagggg acgtgccaac ccaagataaa tctgcagtta  19320

catctttgct ggatggactg aaccaagcct tcgaggaggt ttcatcccag agtggagggg  19380

caaagaggca gagtatacac ttggagcaga agttgtatga tggagtctca gccacctcta  19440

cttggttgga tgacgttgaa gaacgtttat ttgttgccac agcactttta ccagaagaaa  19500

cagagacttg tctcttcaac caagagattc ttgccaaaga cattaaggaa atgtctgaag  19560

aaatggataa gaacaaaaac ttgttttccc aagcttttcc agagaatggt gataatcgag  19620

atgttattga agatactttg ggttgtcttt tgggcaggtt atccttgcta gactcagtag  19680

tgaatcaacg atgtcatcag atgaaagaaa gacttcagca aatactaaat ttccagaatg  19740

atctgaaagt gctgtttaca tcactggctg acaacaaata catcattctg caaaaactgg  19800

caaatgtgtt tgaacagccc gtagcagaac aaatagaggc aatacaacag gctgaagatg  19860

gactcaaaga atttgatgca ggaatcattg aattaaagag gcgtggtgac aagctacagg  19920

tcgagcagcc gtccatgcaa gaactctcca agctccagga catgtatgat gagctgatga  19980

tgatcattgg ctcccggagg agtggtctga atcagaacct tacactcaag agtcagtatg  20040

agagggccct acaagatctg gctgacctgc tagaaactgg tcaggagaag atggcaggag  20100

accagaaaat catcgtgtct tccaaagagg aaatccagca actacttgac aaacataagg  20160

aatactttca gggcctggaa tctcatatga tcttgactga aacactcttc agaaagataa  20220

tcagctttgc agtccaaaag gaaacccagt tccatacaga gctgatggct caggcttctg  20280

ctgtactgaa acgggctcac aagaggggtg tggagctgga gtacattcta gagacgtggt  20340

cccatctgga tgaggaccag caggagctca gcagacagct ggaggtggtg gaaagcagca  20400

tcccaagcgt gggtctggtg gaggagaacg aggacaggct tattgaccgc ataacactct  20460

accagcattt aaaatctagc cttaatgaat accagcccaa attatatcaa gtattagatg  20520

atgggaaacg acttctgata tccatcagct gctcagatct agaaagccaa ctaaatcaac  20580

ttggagagtg ctggctaagt aacaccaata aaatgtctaa ggaacttcac agactggaaa  20640

caatattgaa acactggacc agatatcaaa gtgaatctgc agatctaatt cactggttac  20700

aatctgcaaa agaccggcta gaattttgga ctcagcaatc tgtgacagtc ccacaagagc  20760

tggaaatggt ccgtgatcat ctaaatgctt tcctggagtt ttctaaagaa gtggatgccc  20820

aatcttccct gaaatcatct gttctgagta ctggaaatca gctccttcga ctaaaaaagg  20880

tggacacagc cacgctgcgc tctgagctgt cgcgcattga tagccagtgg actgacctgc  20940

taaccaatat cccagccgtc caggagaagc tccaccagct ccagatggat aaactgcctt  21000

cccgccatgc catttctgaa gtcatgagtt ggatttctct aatggaaaat gttattcaga  21060

aggatgaaga taatattaaa aattccatag gttacaaggc aattcatgaa taccttcaga  21120

aatataaggg ttttaagata gacattaact gtaaacagct gacagtggat tttgtgaacc  21180

agtccgtgct acaaatcagc agtcaggatg tggaaagtaa gcgtagtgat aagactgatt  21240

ttgctgagca acttggagca atgaataaaa gttggcaaat tctgcaaggt ctagtaactg  21300

agaagatcca gctgttggaa ggcttattgg aatcttggtc agaatatgaa aataatgtac  21360

aatgtctgaa aacatggttt gaaacccagg aaaagagact aaaacaacag catcgaattg  21420

gagatcaggc ttctgttcaa aatgcactga aagactgtca ggatctggaa gatttgatta  21480

aagcaaaaga aaaagaagta gagaaaattg agcagaatgg acttgctttg attcagaaca  21540

agaaagaaga cgtctctagc attgtcatga gcacactgcg agagctcggc caaacctggg  21600

caaatttaga tcacatggtt ggacaattaa agatactgct gaaatcagtg cttgaccaat  21660

ggagtagtca caaagtggcc tttgacaaga taaacagtta cctcatggag gccagatact  21720

ctctttcccg attccgtctg ctgactggct ccttagaagc tgtgcaagtt caggtggaca  21780

atcttcagaa tctccaagat gatctggaaa aacaggaaag gagcttacag aaatttggct  21840

ctatcaccaa ccaattatta aaagagtgtc acccacccgt gacagaaact cttaccaata  21900

cactgaaaga agtcaacatg agatggaata acttgctgga agagattgct gagcagctac  21960

agtccagcaa ggccctactt cagctttggc aaagatacaa ggactactcc aaacagtgtg  22020

cttcgacagt tcagcagcag gaggatcgaa ccaatgagct gttgaaggca gccacaaaca  22080

aggacattgc cgatgatgag gttgccacat ggattcaaga ttgcaacgac ctcctcaaag  22140

gactgggcac agttaaagat tccctctttt ttctccatga gctgggagag caactgaagc  22200

aacaagtgga tgcttccgca gcatcagcta ttcaatcgga tcaactctct ttgagtcaac  22260

acttgtgtgc cctggagcaa gctctctgca aacagcagac ttcattacag gctggagttc  22320

ttgattatga aacctttgcc aagagtttag aagctttgga ggcctggata gtggaagctg  22380

aagaaatact acaagggcag gaccctagcc actcatctga cctctccaca atccaggaaa  22440

ggatggaaga acttaaggga cagatgttaa aattcagcag catggctcca gatttagacc  22500

gtctaaatga gcttggatat aggttaccct tgaatgataa ggaaatcaaa agaatgcaga  22560

atctgaaccg ccattggtct ctgatctcct ctcagactac agaaagattc agcaagttgc  22620

agtcattttt gctacaacat cagactttct tggaaaaatg tgaaacatgg atggaattcc  22680

tagttcagac agaacaaaag ttagcagtag agatttcagg aaattatcag caccttttgg  22740

aacagcagag agcacacgag ttgtttcaag ccgagatgtt cagtcgtcag cagattttgc  22800

actcaatcat tattgatggg caacgtcttc tagaacaagg tcaagttgat gacagggatg  22860

aattcaacct gaaattgaca ctcctcagta atcaatggca gggagtgatt cgcagggccc  22920

agcagaggcg ggggatcatt gacagccaga ttcgccagtg gcagcgctat agggagatgg  22980

cagaaaagct tcgtaaatgg ttggttgaag tgtcctacct ccccatgagt ggtctcggaa  23040

gtgttcctat accactgcaa caagcaagga ccctctttga tgaagtgcag ttcaaagaaa  23100

aagtgtttct gcggcaacaa ggcagctaca tcctgactgt ggaggctggc aagcaactcc  23160

ttctctcggc ggacagtggc gctgaggccg ccttgcaggc cgaactcgct gaaatccaag  23220

agaaatggaa atcagccagc atgcggctgg aagaacagaa gaaaaaacta gccttcttgt  23280

tgaaagactg ggaaaaatgt gagaaaggaa tagcagattc cctggagaaa ctacgaactt  23340

tcaaaaagaa gctttcgcag tctctcccgg atcaccatga agagctccat gcagaacaaa  23400

tgcgttgcaa ggaattagaa aatgcagttg ggagctggac agatgacttg acccagttga  23460

gcctgctgaa ggacaccctc tctgcctata tcagtgctga tgatatctcc attcttaatg  23520

aacgcgtaga gcttctgcaa aggcagtggg aagaactatg ccaccagctc tccttaaggc  23580

ggcagcaaat aggtgaaaga ttgaatgaat gggcagtctt cagtgaaaag aacaaggaac  23640

tctgtgagtg gttgactcaa atggaaagca aagtttctca gaatggagac attctcattg  23700

aagaaatgat agagaagctc aagaaggatt atcaagagga aattgctatt gctcaagaga  23760

acaaaataca gctccaacaa atgggagaac gacttgctaa agccagccat gaaagcaaag  23820

catctgagat tgaatacaag ctgggaaagg tcaacgaccg gtggcagcat ctcctggacc  23880

tcattgcagc cagggtgaag aagctgaagg agaccctggt agccgtgcag cagcttgata  23940

agaacatgag cagcctgagg acctggctcg ctcacatcga gtcagagctg gccaagccaa  24000

tagtctacga ttcctgtaac tcggaagaaa tacagagaaa gcttaatgag cagcaggagc  24060

ttcagagaga catagagaag cacagtacag gtgttgcatc tgtcctcaac ctgtgtgaag  24120

tcctgctgca cgactgtgac gcctgtgcca ctgatgccga gtgtgactct atacagcagg  24180

ctacgagaaa cctggaccgg cggtggagaa acatttgtgc tatgtccatg gaaaggaggc  24240

tgaaaatcga agagacgtgg cgattgtggc agaaatttct ggatgactat tcacgttttg  24300

aagattggct gaagtcttca gaaaggacag ctgcttttcc cagctcttct ggggtgatct  24360

atacagttgc caaggaagaa ctaaagaaat ttgaggcttt ccagcgacag gtccacgagt  24420

gcctgacgca gctggaactg atcaacaagc agtaccgccg cctggccagg gagaaccgca  24480

ctgattcagc atgtagcctc aaacagatgg ttcacgaagg caaccagaga tgggacaacc  24540

tgcaaaagcg tgtcacctcc atcttgcgca gactcaagca ttttattggc cagcgtgagg  24600

agtttgagac tgcgcgggac agcattctgg tctggctcac agagatggat ctgcagctca  24660

ctaatattga acatttttct gagtgtgatg ttcaagctaa aataaagcaa ctcaaggcct  24720

tccagcagga aatttcactg aaccacaata agattgagca gataattgcc caaggagaac  24780

agctgataga aaagagtgag cccttggatg cagcgatcat cgaggaggaa ctagatgagc  24840

tccgacggta ctgccaggag gtcttcgggc gtgtggaaag ataccataag aaactgatcc  24900

gcctgcctct cccagacgat gagcacgacc tctcagacag ggagctggag ctggaagact  24960

ctgcagctct gtcggacctg cactggcacg accgctctgc agacagcctg ctttctccac  25020

agccttcctc caatctctcc ctctcgctcg ctcagcccct ccggagcgag cggtcaggac  25080

gagacacccc ggctagtgtg gactccatcc ccctggagtg ggatcacgac tatgacctca  25140

gtcgggacct ggagtctgca atgtccagag ctctgccctc tgaggatgaa gaaggtcagg  25200

atgacaaaga tttctacctc cggggagctg ttggcttatc agatgtaatg atccccgaaa  25260

gccctgaggc ctatgtaaaa ctcacagaaa atgcaatcaa aaatacctcc ggggaccaca  25320

gtgccctaga gtcacagatc cgacaactgg gcaaagccct ggatgatagc cgttttcaga  25380

tacagcaaac cgaaaatatc attcgcagca aaactcccac ggggccggag ctagacacca  25440

gctacaaagg ctacatgaaa ctgctgggcg aatgcagtag cagtatagac tccgtgaaga  25500

gactggagca caaactgaag gaggaagagg agagccttcc tggctttgtt aacctgcata  25560

gtaccgaaac ccaaacggct ggtgtgattg accgatggga gcttctccag gcccaggcat  25620

tgagcaagga gttgaggatg aagcagaacc tccagaagtg gcagcagttt aactcagact  25680

tgaacagcat ctgggcctgg ctgggggaca cggaggagga gttggaacag ctccagcgtc  25740

tggaactcag cactgacatc cagaccatcg agctccagat caaaaagctc aaggagctcc  25800

agaaagctgt ggaccaccgc aaagccatca tcctctccat caatctctgc agccctgagt  25860

tcacccaggc tgacagcaag gagagccggg acctgcagga tcgcttgtcg cagatgaatg  25920

ggcgctggga ccgagtgtgc tctctgctgg aggagtggcg gggcctgctg caggatgccc  25980

tgatgcagtg ccagggtttc catgaaatga gccatggttt gcttcttatg ctggagaaca  26040

ttgacagaag gaaaaatgaa attgtcccta ttgattctaa ccttgatgca gagatacttc  26100

aggaccatca caaacagctt atgcaaataa agcatgagct gttggaatcc caactcagag  26160

tagcctcttt gcaagacatg tcttgccaac tactggtgaa tgctgaagga acagactgtt  26220

tagaagccaa agaaaaagtc catgttattg gaaatcggct caaacttctc ttgaaggagg  26280

tcagtcgtca tatcaaggaa ctggagaagt tattagacgt gtcaagtagt cagcaggatt  26340

tgtcttcctg gtcttctgct gatgaactgg acacctcagg gtctgtgagt cccacatcag  26400

gaaggagcac cccaaacaga cagaaaacgc cacgaggcaa gtgtagtctc tcacagcctg  26460

gaccctctgt cagcagtcca catagcaggt ccacaaaagg tggctccgat tcctcccttt  26520

ctgagccagg gccaggtcgg tccggccgcg gcttcctgtt cagagtcctc cgagcagctc  26580

ttccccttca gcttctcctg ctcctcctca tcgggcttgc ctgccttgta ccaatgtcag  26640

aggaagacta cagctgtgcc ctctccaaca actttgcccg gtcattccac cccatgctca  26700

gatacacgaa tggccctcct ccactctgaa ctaagcagat gccatctgca gaagtgctgg  26760

tagcataagg aggatcgggt cataagcaat cccaaactac caacaagagg accttgatct  26820

tggcgaaagc cctcggtgtg gcagctttag ccctcctcca gatcacatgt gtgcaaatta  26880

tggcttcaga ggtggaagat aaacagtgac gggggaacaa acagacaaca agaaggtttg  26940

gaagaaatct ggtttgagac tctgaacctt agcactaagg agattgagta aggacctcca  27000

aagttccccg gactcatgaa ttctgggccc ttggcccatt ctgtgcacag ccaaggactt  27060

cagtagacca tctgggcagc tttcccatgg tgctgctcca accatcagat aaatgaccct  27120

cccaagcacc atgtcagtgt cgtacaatct accaaccaac cagtgctgaa gagattttag  27180

aaccttgtaa catacaattt ttaagagctt atatggcagc ttccttttta ccttgttttc  27240

ctttggggca tgatgtttta acctttgctt tagaagcaca agctgtaaat ctaaaaggca  27300

ctttttttta gaggtataaa gaaaaactag atgtaataaa taagatcatg gaaggcttta  27360

tgtgaaaaaa gttgaatgtt atagtaaaaa aaaaaagata tttatgtatg tacagtttgc  27420

taaagccaag ttttgtttgt attgatttct ttgcatttat tatagatatt ataaaatagt  27480

t                                                                  27481


<210>  3417
<211>  8749
<212>  PRT
<213>  Homo sapiens

<400>  3417

Met Ala Thr Ser Arg Gly Ala Ser Arg Cys Pro Arg Asp Ile Ala Asn 
1               5                   10                  15


Val Met Gln Arg Leu Gln Asp Glu Gln Glu Ile Val Gln Lys Arg Thr 
            20                  25                  30


Phe Thr Lys Trp Ile Asn Ser His Leu Ala Lys Arg Lys Pro Pro Met 
        35                  40                  45


Val Val Asp Asp Leu Phe Glu Asp Met Lys Asp Gly Val Lys Leu Leu 
    50                  55                  60


Ala Leu Leu Glu Val Leu Ser Gly Gln Lys Leu Pro Cys Glu Gln Gly 
65                  70                  75                  80


Arg Arg Met Lys Arg Ile His Ala Val Ala Asn Ile Gly Thr Ala Leu 
                85                  90                  95


Lys Phe Leu Glu Gly Arg Lys Ser Met His Arg Gly Ser Pro Ile Lys 
            100                 105                 110


Leu Val Asn Ile Asn Ser Thr Asp Ile Ala Asp Gly Arg Pro Ser Ile 
        115                 120                 125


Val Leu Gly Leu Met Trp Thr Ile Ile Leu Tyr Phe Gln Ile Glu Glu 
    130                 135                 140


Leu Thr Ser Asn Leu Pro Gln Leu Gln Ser Leu Ser Ser Ser Ala Ser 
145                 150                 155                 160


Ser Val Asp Ser Ile Val Ser Ser Glu Thr Pro Ser Pro Pro Ser Lys 
                165                 170                 175


Arg Lys Val Thr Thr Lys Ile Gln Gly Asn Ala Lys Lys Ala Leu Leu 
            180                 185                 190


Lys Trp Val Gln Tyr Thr Ala Gly Lys Gln Thr Gly Ile Glu Val Lys 
        195                 200                 205


Asp Phe Gly Lys Ser Trp Arg Ser Gly Val Ala Phe His Ser Val Ile 
    210                 215                 220


His Ala Ile Arg Pro Glu Leu Val Asp Leu Glu Thr Val Lys Gly Arg 
225                 230                 235                 240


Ser Asn Arg Glu Asn Leu Glu Asp Ala Phe Thr Ile Ala Glu Thr Glu 
                245                 250                 255


Leu Gly Ile Pro Arg Leu Leu Asp Pro Glu Asp Val Asp Val Asp Lys 
            260                 265                 270


Pro Asp Glu Lys Ser Ile Met Thr Tyr Val Ala Gln Phe Leu Lys His 
        275                 280                 285


Tyr Pro Asp Ile His Asn Ala Ser Thr Asp Gly Gln Glu Asp Asp Glu 
    290                 295                 300


Ile Leu Pro Gly Phe Pro Ser Phe Ala Asn Ser Val Gln Asn Phe Lys 
305                 310                 315                 320


Arg Glu Asp Arg Val Ile Phe Lys Glu Met Lys Val Trp Ile Glu Gln 
                325                 330                 335


Phe Glu Arg Asp Leu Thr Arg Ala Gln Met Val Glu Ser Asn Leu Gln 
            340                 345                 350


Asp Lys Tyr Gln Ser Phe Lys His Phe Arg Val Gln Tyr Glu Met Lys 
        355                 360                 365


Arg Lys Gln Ile Glu His Leu Ile Gln Pro Leu His Arg Asp Gly Lys 
    370                 375                 380


Leu Ser Leu Asp Gln Ala Leu Val Lys Gln Ser Trp Asp Arg Val Thr 
385                 390                 395                 400


Ser Arg Leu Phe Asp Trp His Ile Gln Leu Asp Lys Ser Leu Pro Ala 
                405                 410                 415


Pro Leu Gly Thr Ile Gly Ala Trp Leu Tyr Arg Ala Glu Val Ala Leu 
            420                 425                 430


Arg Glu Glu Ile Thr Val Gln Gln Val His Glu Glu Thr Ala Asn Thr 
        435                 440                 445


Ile Gln Arg Lys Leu Glu Gln His Lys Asp Leu Leu Gln Asn Thr Asp 
    450                 455                 460


Ala His Lys Arg Ala Phe His Glu Ile Tyr Arg Thr Arg Ser Val Asn 
465                 470                 475                 480


Gly Ile Pro Val Pro Pro Asp Gln Leu Glu Asp Met Ala Glu Arg Phe 
                485                 490                 495


His Phe Val Ser Ser Thr Ser Glu Leu His Leu Met Lys Met Glu Phe 
            500                 505                 510


Leu Glu Leu Lys Tyr Arg Leu Leu Ser Leu Leu Val Leu Ala Glu Ser 
        515                 520                 525


Lys Leu Lys Ser Trp Ile Ile Lys Tyr Gly Arg Arg Glu Ser Val Glu 
    530                 535                 540


Gln Leu Leu Gln Asn Tyr Val Ser Phe Ile Glu Asn Ser Lys Phe Phe 
545                 550                 555                 560


Glu Gln Tyr Glu Val Thr Tyr Gln Ile Leu Lys Gln Thr Ala Glu Met 
                565                 570                 575


Tyr Val Lys Ala Asp Gly Ser Val Glu Glu Ala Glu Asn Val Met Lys 
            580                 585                 590


Phe Met Asn Glu Thr Thr Ala Gln Trp Arg Asn Leu Ser Val Glu Val 
        595                 600                 605


Arg Ser Val Arg Ser Met Leu Glu Glu Val Ile Ser Asn Trp Asp Arg 
    610                 615                 620


Tyr Gly Asn Thr Val Ala Ser Leu Gln Ala Trp Leu Glu Asp Ala Glu 
625                 630                 635                 640


Lys Met Leu Asn Gln Ser Glu Asn Ala Lys Lys Asp Phe Phe Arg Asn 
                645                 650                 655


Leu Pro His Trp Ile Gln Gln His Thr Ala Met Asn Asp Ala Gly Asn 
            660                 665                 670


Phe Leu Ile Glu Thr Cys Asp Glu Met Val Ser Arg Asp Leu Lys Gln 
        675                 680                 685


Gln Leu Leu Leu Leu Asn Gly Arg Trp Arg Glu Leu Phe Met Glu Val 
    690                 695                 700


Lys Gln Tyr Ala Gln Ala Asp Glu Met Asp Arg Met Lys Lys Glu Tyr 
705                 710                 715                 720


Thr Asp Cys Val Val Thr Leu Ser Ala Phe Ala Thr Glu Ala His Lys 
                725                 730                 735


Lys Leu Ser Glu Pro Leu Glu Val Ser Phe Met Asn Val Lys Leu Leu 
            740                 745                 750


Ile Gln Asp Leu Glu Asp Ile Glu Gln Arg Val Pro Val Met Asp Ala 
        755                 760                 765


Gln Tyr Lys Ile Ile Thr Lys Thr Ala His Leu Ile Thr Lys Glu Ser 
    770                 775                 780


Pro Gln Glu Glu Gly Lys Glu Met Phe Ala Thr Met Ser Lys Leu Lys 
785                 790                 795                 800


Glu Gln Leu Thr Lys Val Lys Glu Cys Tyr Ser Pro Leu Leu Tyr Glu 
                805                 810                 815


Ser Gln Gln Leu Leu Ile Pro Leu Glu Glu Leu Glu Lys Gln Met Thr 
            820                 825                 830


Ser Phe Tyr Asp Ser Leu Gly Lys Ile Asn Glu Ile Ile Thr Val Leu 
        835                 840                 845


Glu Arg Glu Ala Gln Ser Ser Ala Leu Phe Lys Gln Lys His Gln Glu 
    850                 855                 860


Leu Leu Ala Cys Gln Glu Asn Cys Lys Lys Thr Leu Thr Leu Ile Glu 
865                 870                 875                 880


Lys Gly Ser Gln Ser Val Gln Lys Phe Val Thr Leu Ser Asn Val Leu 
                885                 890                 895


Lys His Phe Asp Gln Thr Arg Leu Gln Arg Gln Ile Ala Asp Ile His 
            900                 905                 910


Val Ala Phe Gln Ser Met Val Lys Lys Thr Gly Asp Trp Lys Lys His 
        915                 920                 925


Val Glu Thr Asn Ser Arg Leu Met Lys Lys Phe Glu Glu Ser Arg Ala 
    930                 935                 940


Glu Leu Glu Lys Val Leu Arg Ile Ala Gln Glu Gly Leu Glu Glu Lys 
945                 950                 955                 960


Gly Asp Pro Glu Glu Leu Leu Arg Arg His Thr Glu Phe Phe Ser Gln 
                965                 970                 975


Leu Asp Gln Arg Val Leu Asn Ala Phe Leu Lys Ala Cys Asp Glu Leu 
            980                 985                 990


Thr Asp Ile Leu Pro Glu Gln Glu Gln Gln Gly Leu Gln Glu Ala Val 
        995                 1000                1005


Arg Lys Leu His Lys Gln Trp Lys Asp Leu Gln Gly Glu Ala Pro Tyr 
    1010                1015                1020


His Leu Leu His Leu Lys Ile Asp Val Glu Lys Asn Arg Phe Leu Ala 
1025                1030                1035                1040


Ser Val Glu Glu Cys Arg Thr Glu Leu Asp Arg Glu Thr Lys Leu Met 
                1045                1050                1055


Pro Gln Glu Gly Ser Glu Lys Ile Ile Lys Glu His Arg Val Phe Phe 
            1060                1065                1070


Ser Asp Lys Gly Pro His His Leu Cys Glu Lys Arg Leu Gln Leu Ile 
        1075                1080                1085


Glu Glu Leu Cys Val Lys Leu Pro Val Arg Asp Pro Val Arg Asp Thr 
    1090                1095                1100


Pro Gly Thr Cys His Val Thr Leu Lys Glu Leu Arg Ala Ala Ile Asp 
1105                1110                1115                1120


Ser Thr Tyr Arg Lys Leu Met Glu Asp Pro Asp Lys Trp Lys Asp Tyr 
                1125                1130                1135


Thr Ser Arg Phe Ser Glu Phe Ser Ser Trp Ile Ser Thr Asn Glu Thr 
            1140                1145                1150


Gln Leu Lys Gly Ile Lys Gly Glu Ala Ile Asp Thr Ala Asn His Gly 
        1155                1160                1165


Glu Val Lys Arg Ala Val Glu Glu Ile Arg Asn Gly Val Thr Lys Arg 
    1170                1175                1180


Gly Glu Thr Leu Ser Trp Leu Lys Ser Arg Leu Lys Val Leu Thr Glu 
1185                1190                1195                1200


Val Ser Ser Glu Asn Glu Ala Gln Lys Gln Gly Asp Glu Leu Ala Lys 
                1205                1210                1215


Leu Ser Ser Ser Phe Lys Ala Leu Val Thr Leu Leu Ser Glu Val Glu 
            1220                1225                1230


Lys Met Leu Ser Asn Phe Gly Asp Cys Val Gln Tyr Lys Glu Ile Val 
        1235                1240                1245


Lys Asn Ser Leu Glu Glu Leu Ile Ser Gly Ser Lys Glu Val Gln Glu 
    1250                1255                1260


Gln Ala Glu Lys Ile Leu Asp Thr Glu Asn Leu Phe Glu Ala Gln Gln 
1265                1270                1275                1280


Leu Leu Leu His His Gln Gln Lys Thr Lys Arg Ile Ser Ala Lys Lys 
                1285                1290                1295


Arg Asp Val Gln Gln Gln Ile Ala Gln Ala Gln Gln Gly Glu Gly Gly 
            1300                1305                1310


Leu Pro Asp Arg Gly His Glu Glu Leu Arg Lys Leu Glu Ser Thr Leu 
        1315                1320                1325


Asp Gly Leu Glu Arg Ser Arg Glu Arg Gln Glu Arg Arg Ile Gln Val 
    1330                1335                1340


Thr Leu Arg Lys Trp Glu Arg Phe Glu Thr Asn Lys Glu Thr Val Val 
1345                1350                1355                1360


Arg Tyr Leu Phe Gln Thr Gly Ser Ser His Glu Arg Phe Leu Ser Phe 
                1365                1370                1375


Ser Ser Leu Glu Ser Leu Ser Ser Glu Leu Glu Gln Thr Lys Glu Phe 
            1380                1385                1390


Ser Lys Arg Thr Glu Ser Ile Ala Val Gln Ala Glu Asn Leu Val Lys 
        1395                1400                1405


Glu Ala Ser Glu Ile Pro Leu Gly Pro Gln Asn Lys Gln Leu Leu Gln 
    1410                1415                1420


Gln Gln Ala Lys Ser Ile Lys Glu Gln Val Lys Lys Leu Glu Asp Thr 
1425                1430                1435                1440


Leu Glu Glu Asp Ile Lys Thr Met Glu Met Val Lys Thr Lys Trp Asp 
                1445                1450                1455


His Phe Gly Ser Asn Phe Glu Thr Leu Ser Val Trp Ile Thr Glu Lys 
            1460                1465                1470


Glu Lys Glu Leu Asn Ala Leu Glu Thr Ser Ser Ser Ala Met Asp Met 
        1475                1480                1485


Gln Ile Ser Gln Ile Lys Val Thr Ile Gln Glu Ile Glu Ser Lys Leu 
    1490                1495                1500


Ser Ser Ile Val Gly Leu Glu Glu Glu Ala Gln Ser Phe Ala Gln Phe 
1505                1510                1515                1520


Val Thr Thr Gly Glu Ser Ala Arg Ile Lys Ala Lys Leu Thr Gln Ile 
                1525                1530                1535


Arg Arg Tyr Gly Glu Glu Leu Arg Glu His Ala Gln Cys Leu Glu Gly 
            1540                1545                1550


Thr Ile Leu Gly His Leu Ser Gln Gln Gln Lys Phe Glu Glu Asn Leu 
        1555                1560                1565


Arg Lys Ile Gln Gln Ser Val Ser Glu Phe Glu Asp Lys Leu Ala Val 
    1570                1575                1580


Pro Ile Lys Ile Cys Ser Ser Ala Thr Glu Thr Tyr Lys Val Leu Gln 
1585                1590                1595                1600


Glu His Met Asp Leu Cys Gln Ala Leu Glu Ser Leu Ser Ser Ala Ile 
                1605                1610                1615


Thr Ala Phe Ser Ala Ser Ala Arg Lys Val Val Asn Arg Asp Ser Cys 
            1620                1625                1630


Val Gln Glu Ala Ala Ala Leu Gln Gln Gln Tyr Glu Asp Ile Leu Arg 
        1635                1640                1645


Arg Ala Lys Glu Arg Gln Thr Ala Leu Glu Asn Leu Leu Ala His Trp 
    1650                1655                1660


Gln Arg Leu Glu Lys Glu Leu Ser Ser Phe Leu Thr Trp Leu Glu Arg 
1665                1670                1675                1680


Gly Glu Ala Lys Ala Ser Ser Pro Glu Met Asp Ile Ser Ala Asp Arg 
                1685                1690                1695


Val Lys Val Glu Gly Glu Leu Gln Leu Ile Gln Ala Leu Gln Asn Glu 
            1700                1705                1710


Val Val Ser Gln Ala Ser Phe Tyr Ser Lys Leu Leu Gln Leu Lys Glu 
        1715                1720                1725


Ser Leu Phe Ser Val Ala Ser Lys Asp Asp Val Lys Met Met Lys Leu 
    1730                1735                1740


His Leu Glu Gln Leu Asp Glu Arg Trp Arg Asp Leu Pro Gln Ile Ile 
1745                1750                1755                1760


Asn Lys Arg Ile Asn Phe Leu Gln Ser Val Val Ala Glu His Gln Gln 
                1765                1770                1775


Phe Asp Glu Leu Leu Leu Ser Phe Ser Val Trp Ile Lys Leu Phe Leu 
            1780                1785                1790


Ser Glu Leu Gln Thr Thr Ser Glu Ile Ser Ile Met Asp His Gln Val 
        1795                1800                1805


Ala Leu Thr Arg His Lys Asp His Ala Ala Glu Val Glu Ser Lys Lys 
    1810                1815                1820


Gly Glu Leu Gln Ser Leu Gln Gly His Leu Ala Lys Leu Gly Ser Leu 
1825                1830                1835                1840


Gly Arg Ala Glu Asp Leu His Leu Leu Gln Gly Lys Ala Glu Asp Cys 
                1845                1850                1855


Phe Gln Leu Phe Glu Glu Ala Ser Gln Val Val Glu Arg Arg Gln Leu 
            1860                1865                1870


Ala Leu Ser His Leu Ala Glu Phe Leu Gln Ser His Ala Ser Leu Ser 
        1875                1880                1885


Gly Ile Leu Arg Gln Leu Arg Gln Thr Val Glu Ala Thr Asn Ser Met 
    1890                1895                1900


Asn Lys Asn Glu Ser Asp Leu Ile Glu Lys Asp Leu Asn Asp Ala Leu 
1905                1910                1915                1920


Gln Asn Ala Lys Ala Leu Glu Ser Ala Ala Val Ser Leu Asp Gly Ile 
                1925                1930                1935


Leu Ser Lys Ala Gln Tyr His Leu Lys Ile Gly Ser Ser Glu Gln Arg 
            1940                1945                1950


Thr Ser Cys Arg Ala Thr Ala Asp Gln Leu Cys Gly Glu Val Glu Arg 
        1955                1960                1965


Ile Gln Asn Leu Leu Gly Thr Lys Gln Ser Glu Ala Asp Ala Leu Ala 
    1970                1975                1980


Val Leu Lys Lys Ala Phe Gln Asp Gln Lys Glu Glu Leu Leu Lys Ser 
1985                1990                1995                2000


Ile Glu Asp Ile Glu Glu Arg Thr Asp Lys Glu Arg Leu Lys Glu Pro 
                2005                2010                2015


Thr Arg Gln Ala Leu Gln Gln Arg Leu Arg Val Phe Asn Gln Leu Glu 
            2020                2025                2030


Asp Glu Leu Asn Ser His Glu His Glu Leu Cys Trp Leu Lys Asp Lys 
        2035                2040                2045


Ala Lys Gln Ile Ala Gln Lys Asp Val Ala Phe Ala Pro Glu Val Asp 
    2050                2055                2060


Arg Glu Ile Asn Arg Leu Glu Val Thr Trp Asp Asp Thr Lys Arg Leu 
2065                2070                2075                2080


Ile His Glu Asn Gln Gly Gln Cys Cys Gly Leu Ile Asp Leu Met Arg 
                2085                2090                2095


Glu Tyr Gln Asn Leu Lys Ser Ala Val Ser Lys Val Leu Glu Asn Ala 
            2100                2105                2110


Ser Ser Val Ile Val Thr Arg Thr Thr Ile Lys Asp Gln Glu Asp Leu 
        2115                2120                2125


Lys Trp Ala Phe Ser Lys His Glu Thr Ala Lys Asn Lys Met Asn Tyr 
    2130                2135                2140


Lys Gln Lys Asp Leu Asp Asn Phe Thr Ser Lys Gly Lys His Leu Leu 
2145                2150                2155                2160


Ser Glu Leu Lys Lys Ile His Ser Ser Asp Phe Ser Leu Val Lys Thr 
                2165                2170                2175


Asp Met Glu Ser Thr Val Asp Lys Trp Leu Asp Val Ser Glu Lys Leu 
            2180                2185                2190


Glu Glu Asn Met Asp Arg Leu Arg Val Ser Leu Ser Ile Trp Asp Asp 
        2195                2200                2205


Val Leu Ser Thr Arg Asp Glu Ile Glu Gly Trp Ser Asn Asn Cys Val 
    2210                2215                2220


Pro Gln Met Ala Glu Asn Ile Ser Asn Leu Asp Asn His Leu Arg Ala 
2225                2230                2235                2240


Glu Glu Leu Leu Lys Glu Phe Glu Ser Glu Val Lys Asn Lys Ala Leu 
                2245                2250                2255


Arg Leu Glu Glu Leu His Ser Lys Val Asn Asp Leu Lys Glu Leu Thr 
            2260                2265                2270


Lys Asn Leu Glu Thr Pro Pro Asp Leu Gln Phe Ile Glu Ala Asp Leu 
        2275                2280                2285


Met Gln Lys Leu Glu His Ala Lys Glu Ile Thr Glu Val Ala Lys Gly 
    2290                2295                2300


Thr Leu Lys Asp Phe Thr Ala Gln Ser Thr Gln Val Glu Lys Phe Ile 
2305                2310                2315                2320


Asn Asp Ile Thr Thr Trp Phe Thr Lys Val Glu Glu Ser Leu Met Asn 
                2325                2330                2335


Cys Ala Gln Asn Glu Thr Cys Glu Ala Leu Lys Lys Val Lys Asp Ile 
            2340                2345                2350


Gln Lys Glu Leu Gln Ser Gln Gln Ser Asn Ile Ser Ser Thr Gln Glu 
        2355                2360                2365


Asn Leu Asn Ser Leu Cys Arg Lys Tyr His Ser Ala Glu Leu Glu Ser 
    2370                2375                2380


Leu Gly Arg Ala Met Thr Gly Leu Ile Lys Lys His Glu Ala Val Ser 
2385                2390                2395                2400


Gln Leu Cys Ser Lys Thr Gln Ala Ser Leu Gln Glu Ser Leu Glu Lys 
                2405                2410                2415


His Phe Ser Glu Ser Met Gln Glu Phe Gln Glu Trp Phe Leu Gly Ala 
            2420                2425                2430


Lys Ala Ala Ala Lys Glu Ser Ser Asp Arg Thr Gly Asp Ser Lys Val 
        2435                2440                2445


Leu Glu Ala Lys Leu His Asp Leu Gln Asn Ile Leu Asp Ser Val Ser 
    2450                2455                2460


Asp Gly Gln Ser Lys Leu Asp Ala Val Thr Gln Glu Gly Gln Thr Leu 
2465                2470                2475                2480


Tyr Ala His Leu Ser Lys Gln Ile Val Ser Ser Ile Gln Glu Gln Ile 
                2485                2490                2495


Thr Lys Ala Asn Glu Glu Phe Gln Ala Phe Leu Lys Gln Cys Leu Lys 
            2500                2505                2510


Asp Lys Gln Ala Leu Gln Asp Cys Ala Ser Glu Leu Gly Ser Phe Glu 
        2515                2520                2525


Asp Gln His Arg Lys Leu Asn Leu Trp Ile His Glu Met Glu Glu Arg 
    2530                2535                2540


Phe Asn Thr Glu Asn Leu Gly Glu Ser Lys Gln His Ile Pro Glu Lys 
2545                2550                2555                2560


Lys Asn Glu Val His Lys Val Glu Met Phe Leu Gly Glu Leu Leu Ala 
                2565                2570                2575


Ala Arg Glu Ser Leu Asp Lys Leu Ser Gln Arg Gly Gln Leu Leu Ser 
            2580                2585                2590


Glu Glu Gly His Gly Ala Gly Gln Glu Gly Arg Leu Cys Ser Gln Leu 
        2595                2600                2605


Leu Thr Ser His Gln Asn Leu Leu Arg Met Thr Lys Glu Lys Leu Arg 
    2610                2615                2620


Ser Cys Gln Val Ala Leu Gln Glu His Glu Ala Leu Glu Glu Ala Leu 
2625                2630                2635                2640


Gln Ser Met Trp Phe Trp Val Lys Ala Ile Gln Asp Arg Leu Ala Cys 
                2645                2650                2655


Ala Glu Ser Thr Leu Gly Ser Lys Asp Thr Leu Glu Lys Arg Leu Ser 
            2660                2665                2670


Gln Ile Gln Asp Ile Leu Leu Met Lys Gly Glu Gly Glu Val Lys Leu 
        2675                2680                2685


Asn Met Ala Ile Gly Lys Gly Glu Gln Ala Leu Arg Ser Ser Asn Lys 
    2690                2695                2700


Glu Gly Gln Arg Val Ile Gln Thr Gln Leu Glu Thr Leu Lys Glu Val 
2705                2710                2715                2720


Trp Ala Asp Ile Met Ser Ser Ser Val His Ala Gln Ser Thr Leu Glu 
                2725                2730                2735


Ser Val Ile Ser Gln Trp Asn Asp Tyr Val Glu Arg Lys Asn Gln Leu 
            2740                2745                2750


Glu Gln Trp Met Glu Ser Val Asp Gln Lys Ile Glu His Pro Leu Gln 
        2755                2760                2765


Pro Gln Pro Gly Leu Lys Glu Lys Phe Val Leu Leu Asp His Leu Gln 
    2770                2775                2780


Ser Ile Leu Ser Glu Ala Glu Asp His Thr Arg Ala Leu His Arg Leu 
2785                2790                2795                2800


Ile Ala Lys Ser Arg Glu Leu Tyr Glu Lys Thr Glu Asp Glu Ser Phe 
                2805                2810                2815


Lys Asp Thr Ala Gln Glu Glu Leu Lys Thr Gln Phe Asn Asp Ile Met 
            2820                2825                2830


Thr Val Ala Lys Glu Lys Met Arg Lys Val Glu Glu Ile Val Lys Asp 
        2835                2840                2845


His Leu Met Tyr Leu Asp Ala Val His Glu Phe Thr Asp Trp Leu His 
    2850                2855                2860


Ser Ala Lys Glu Glu Leu His Arg Trp Ser Asp Met Ser Gly Asp Ser 
2865                2870                2875                2880


Ser Ala Thr Gln Lys Lys Leu Ser Lys Ile Lys Glu Leu Ile Asp Ser 
                2885                2890                2895


Arg Glu Ile Gly Ala Ser Arg Leu Ser Arg Val Glu Ser Leu Ala Pro 
            2900                2905                2910


Glu Val Lys Gln Asn Thr Thr Ala Ser Gly Cys Glu Leu Met His Thr 
        2915                2920                2925


Glu Met Gln Ala Leu Arg Ala Asp Trp Lys Gln Trp Glu Asp Ser Val 
    2930                2935                2940


Phe Gln Thr Gln Ser Cys Leu Glu Asn Leu Val Ser Gln Met Ala Leu 
2945                2950                2955                2960


Ser Glu Gln Glu Phe Ser Gly Gln Val Ala Gln Leu Glu Gln Ala Leu 
                2965                2970                2975


Glu Gln Phe Ser Ala Leu Leu Lys Thr Trp Ala Gln Gln Leu Thr Leu 
            2980                2985                2990


Leu Glu Gly Lys Asn Thr Asp Glu Glu Ile Val Glu Cys Trp His Lys 
        2995                3000                3005


Gly Gln Glu Ile Leu Asp Ala Leu Gln Lys Ala Glu Pro Arg Thr Glu 
    3010                3015                3020


Asp Leu Lys Ser Gln Leu Asn Glu Leu Cys Arg Phe Ser Arg Asp Leu 
3025                3030                3035                3040


Ser Thr Tyr Ser Gly Lys Val Ser Gly Leu Ile Lys Glu Tyr Asn Cys 
                3045                3050                3055


Leu Cys Leu Gln Ala Ser Lys Gly Cys Gln Asn Lys Glu Gln Ile Leu 
            3060                3065                3070


Gln Gln Arg Phe Arg Lys Ala Phe Arg Asp Phe Gln Gln Trp Leu Val 
        3075                3080                3085


Asn Ala Lys Ile Thr Thr Ala Lys Cys Phe Asp Ile Pro Gln Asn Ile 
    3090                3095                3100


Ser Glu Val Ser Thr Ser Leu Gln Lys Ile Gln Glu Phe Leu Ser Glu 
3105                3110                3115                3120


Ser Glu Asn Gly Gln His Lys Leu Asn Met Met Leu Ser Lys Gly Glu 
                3125                3130                3135


Leu Leu Ser Thr Leu Leu Thr Lys Glu Lys Ala Lys Gly Ile Gln Ala 
            3140                3145                3150


Lys Val Thr Ala Ala Lys Glu Asp Trp Lys Asn Phe His Ser Asn Leu 
        3155                3160                3165


His Gln Lys Glu Ser Ala Leu Glu Asn Leu Lys Ile Gln Met Lys Asp 
    3170                3175                3180


Phe Glu Val Ser Ala Glu Pro Ile Gln Asp Trp Leu Ser Lys Thr Glu 
3185                3190                3195                3200


Lys Met Val His Glu Ser Ser Asn Arg Leu Tyr Asp Leu Pro Ala Lys 
                3205                3210                3215


Arg Arg Glu Gln Gln Lys Leu Gln Ser Val Leu Glu Glu Ile His Cys 
            3220                3225                3230


Tyr Glu Pro Gln Leu Asn Arg Leu Lys Glu Lys Ala Gln Gln Leu Trp 
        3235                3240                3245


Glu Gly Gln Ala Ala Ser Lys Ser Phe Arg His Arg Val Ser Gln Leu 
    3250                3255                3260


Ser Ser Gln Tyr Leu Ala Leu Ser Asn Leu Thr Lys Glu Lys Val Ser 
3265                3270                3275                3280


Arg Leu Asp Arg Ile Val Ala Glu His Asn Gln Phe Ser Leu Gly Ile 
                3285                3290                3295


Lys Glu Leu Gln Asp Trp Met Thr Asp Ala Ile His Met Leu Asp Ser 
            3300                3305                3310


Tyr Cys His Pro Thr Ser Asp Lys Ser Val Leu Asp Ser Arg Thr Leu 
        3315                3320                3325


Lys Leu Glu Ala Leu Leu Ser Val Lys Gln Glu Lys Glu Ile Gln Met 
    3330                3335                3340


Lys Met Ile Val Thr Arg Gly Glu Ser Val Leu Gln Asn Thr Ser Pro 
3345                3350                3355                3360


Glu Gly Ile Pro Thr Ile Gln Gln Gln Leu Gln Ser Val Lys Asp Met 
                3365                3370                3375


Trp Ala Ser Leu Leu Ser Ala Gly Ile Arg Cys Lys Ser Gln Leu Glu 
            3380                3385                3390


Gly Ala Leu Ser Lys Trp Thr Ser Tyr Gln Asp Gly Val Arg Gln Phe 
        3395                3400                3405


Ser Gly Trp Met Asp Ser Met Glu Ala Asn Leu Asn Glu Ser Glu Arg 
    3410                3415                3420


Gln His Ala Glu Leu Arg Asp Lys Thr Thr Met Leu Gly Lys Ala Lys 
3425                3430                3435                3440


Leu Leu Asn Glu Glu Val Leu Ser Tyr Ser Ser Leu Leu Glu Thr Ile 
                3445                3450                3455


Glu Val Lys Gly Ala Gly Met Thr Glu His Tyr Val Thr Gln Leu Glu 
            3460                3465                3470


Leu Gln Asp Leu Gln Glu Arg Tyr Arg Ala Ile Gln Glu Arg Ala Lys 
        3475                3480                3485


Glu Ala Val Thr Lys Ser Glu Lys Leu Val Arg Leu His Gln Glu Tyr 
    3490                3495                3500


Gln Arg Asp Leu Lys Ala Phe Glu Val Trp Leu Gly Gln Glu Gln Glu 
3505                3510                3515                3520


Lys Leu Asp Gln Tyr Ser Val Leu Glu Gly Asp Ala His Thr His Glu 
                3525                3530                3535


Thr Thr Leu Arg Asp Leu Gln Glu Leu Gln Val His Cys Ala Glu Gly 
            3540                3545                3550


Gln Ala Leu Leu Asn Ser Val Leu His Thr Arg Glu Asp Val Ile Pro 
        3555                3560                3565


Ser Gly Ile Pro Gln Ala Glu Asp Arg Ala Leu Glu Ser Leu Arg Gln 
    3570                3575                3580


Asp Trp Gln Ala Tyr Gln His Arg Leu Ser Glu Thr Arg Thr Gln Phe 
3585                3590                3595                3600


Asn Asn Val Val Asn Lys Leu Arg Leu Met Glu Gln Lys Phe Gln Gln 
                3605                3610                3615


Val Asp Glu Trp Leu Lys Thr Ala Glu Glu Lys Lys Trp His Glu Glu 
            3620                3625                3630


Val Thr Ala Tyr Arg Asp Glu Val Glu Glu Val Gly Ala Arg Ala Gln 
        3635                3640                3645


Glu Ile Leu Asp Glu Ser His Val Asn Ser Arg Met Gly Cys Gln Ala 
    3650                3655                3660


Thr Gln Leu Thr Ser Arg Tyr Gln Ala Leu Leu Leu Gln Val Leu Glu 
3665                3670                3675                3680


Gln Ile Lys Phe Leu Glu Glu Glu Ile Gln Ser Leu Glu Glu Ser Glu 
                3685                3690                3695


Ser Ser Leu Ser Ser Tyr Ser Asp Trp Tyr Gly Ser Thr His Lys Asn 
            3700                3705                3710


Phe Lys Asn Val Ala Thr Lys Ile Asp Lys Val Asp Thr Val Met Met 
        3715                3720                3725


Gly Lys Lys Leu Lys Thr Leu Glu Val Leu Leu Lys Asp Met Glu Lys 
    3730                3735                3740


Gly His Ser Leu Leu Lys Ser Ala Arg Glu Lys Gly Glu Arg Ala Val 
3745                3750                3755                3760


Lys Tyr Leu Glu Glu Gly Glu Ala Glu Arg Leu Arg Lys Glu Ile His 
                3765                3770                3775


Asp His Met Glu Gln Leu Lys Glu Leu Thr Ser Thr Val Arg Lys Glu 
            3780                3785                3790


His Met Thr Leu Glu Lys Gly Leu His Leu Ala Lys Glu Phe Ser Asp 
        3795                3800                3805


Lys Cys Lys Ala Leu Thr Gln Trp Ile Ala Glu Tyr Gln Glu Ile Leu 
    3810                3815                3820


His Val Pro Glu Glu Pro Lys Met Glu Leu Tyr Glu Lys Lys Ala Gln 
3825                3830                3835                3840


Leu Ser Lys Tyr Lys Ser Leu Gln Gln Thr Val Leu Ser His Glu Pro 
                3845                3850                3855


Ser Val Lys Ser Val Arg Glu Lys Gly Glu Ala Leu Leu Glu Leu Val 
            3860                3865                3870


Gln Asp Val Thr Leu Lys Asp Lys Ile Asp Gln Leu Gln Ser Asp Tyr 
        3875                3880                3885


Gln Asp Leu Cys Ser Ile Gly Lys Ala Met Met Glu Glu Ile Ala Gly 
    3890                3895                3900


Phe Glu Asp Arg Leu Asn Asn Leu Gln Met Lys Gly Asp Thr Leu Ile 
3905                3910                3915                3920


Gly Gln Cys Ala Asp His Leu Gln Ala Lys Leu Lys Gln Asn Val His 
                3925                3930                3935


Ala His Leu Gln Gly Thr Lys Asp Ser Tyr Ser Ala Ile Cys Ser Thr 
            3940                3945                3950


Ala Gln Arg Met Tyr Gln Ser Leu Glu His Glu Leu Gln Lys His Val 
        3955                3960                3965


Ser Arg Gln Asp Thr Leu Gln Gln Cys Gln Ala Trp Leu Ser Ala Val 
    3970                3975                3980


Gln Pro Asp Leu Glu Pro Ser Pro Gln Pro Pro Leu Ser Arg Ala Glu 
3985                3990                3995                4000


Ala Ile Lys Gln Val Lys His Phe Arg Ala Leu Gln Glu Gln Ala Arg 
                4005                4010                4015


Thr Tyr Leu Asp Leu Leu Cys Ser Met Cys Asp Leu Ser Asn Ala Ser 
            4020                4025                4030


Val Lys Thr Thr Ala Lys Asp Ile Gln Gln Thr Glu Gln Thr Ile Glu 
        4035                4040                4045


Gln Lys Leu Val Gln Ala Gln Asn Leu Thr Gln Gly Trp Glu Glu Ile 
    4050                4055                4060


Lys His Leu Lys Ser Glu Leu Trp Ile Tyr Leu Gln Asp Ala Asp Gln 
4065                4070                4075                4080


Gln Leu Gln Asn Met Lys Arg Arg His Ser Glu Leu Glu Leu Asn Ile 
                4085                4090                4095


Ala Gln Asn Met Val Ser Gln Val Lys Asp Phe Val Lys Lys Leu Gln 
            4100                4105                4110


Ser Lys Gln Ala Ser Val Asn Thr Ile Ile Glu Lys Val Asn Lys Leu 
        4115                4120                4125


Thr Lys Lys Glu Glu Ser Pro Glu His Lys Glu Ile Asn His Leu Asn 
    4130                4135                4140


Asp Gln Trp Leu Asp Leu Cys Arg Gln Ser Asn Asn Leu Cys Leu Gln 
4145                4150                4155                4160


Arg Glu Glu Asp Leu Gln Arg Thr Arg Asp Tyr His Asp Cys Met Asn 
                4165                4170                4175


Val Val Glu Val Phe Leu Glu Lys Phe Thr Thr Glu Trp Asp Asn Leu 
            4180                4185                4190


Ala Arg Ser Asp Ala Glu Ser Thr Ala Val His Leu Glu Ala Leu Lys 
        4195                4200                4205


Lys Leu Ala Leu Ala Leu Gln Glu Arg Lys Tyr Ala Ile Glu Asp Leu 
    4210                4215                4220


Lys Asp Gln Lys Gln Lys Met Ile Glu His Leu Asn Leu Asp Asp Lys 
4225                4230                4235                4240


Glu Leu Val Lys Glu Gln Thr Ser His Leu Glu Gln Arg Trp Phe Gln 
                4245                4250                4255


Leu Glu Asp Leu Ile Lys Arg Lys Ile Gln Val Ser Val Thr Asn Leu 
            4260                4265                4270


Glu Glu Leu Asn Val Val Gln Ser Arg Phe Gln Glu Leu Met Glu Trp 
        4275                4280                4285


Ala Glu Glu Gln Gln Pro Asn Ile Ala Glu Ala Leu Lys Gln Ser Pro 
    4290                4295                4300


Pro Pro Asp Met Ala Gln Asn Leu Leu Met Asp His Leu Ala Ile Cys 
4305                4310                4315                4320


Ser Glu Leu Glu Ala Lys Gln Met Leu Leu Lys Ser Leu Ile Lys Asp 
                4325                4330                4335


Ala Asp Arg Val Met Ala Asp Leu Gly Leu Asn Glu Arg Gln Val Ile 
            4340                4345                4350


Gln Lys Ala Leu Ser Asp Ala Gln Ser His Val Asn Cys Leu Ser Asp 
        4355                4360                4365


Leu Val Gly Gln Arg Arg Lys Tyr Leu Asn Lys Ala Leu Ser Glu Lys 
    4370                4375                4380


Thr Gln Phe Leu Met Ala Val Phe Gln Ala Thr Ser Gln Ile Gln Gln 
4385                4390                4395                4400


His Glu Arg Lys Ile Met Phe Arg Glu His Ile Cys Leu Leu Pro Asp 
                4405                4410                4415


Asp Val Ser Lys Gln Val Lys Thr Cys Lys Ser Ala Gln Ala Ser Leu 
            4420                4425                4430


Lys Thr Tyr Gln Asn Glu Val Thr Gly Leu Trp Ala Gln Gly Arg Glu 
        4435                4440                4445


Leu Met Lys Glu Val Thr Glu Gln Glu Lys Ser Glu Val Leu Gly Lys 
    4450                4455                4460


Leu Gln Glu Leu Gln Ser Val Tyr Asp Ser Val Leu Gln Lys Cys Ser 
4465                4470                4475                4480


His Arg Leu Gln Glu Leu Glu Lys Asn Leu Val Ser Arg Lys His Phe 
                4485                4490                4495


Lys Glu Asp Phe Asp Lys Ala Cys His Trp Leu Lys Gln Ala Asp Ile 
            4500                4505                4510


Val Thr Phe Pro Glu Ile Asn Leu Met Asn Glu Ser Ser Glu Leu His 
        4515                4520                4525


Thr Gln Leu Ala Lys Tyr Gln Asn Ile Leu Glu Gln Ser Pro Glu Tyr 
    4530                4535                4540


Glu Asn Leu Leu Leu Thr Leu Gln Arg Thr Gly Gln Thr Ile Leu Pro 
4545                4550                4555                4560


Ser Leu Asn Glu Val Asp His Ser Tyr Leu Ser Glu Lys Leu Asn Ala 
                4565                4570                4575


Leu Pro Arg Gln Phe Asn Val Ile Val Ala Leu Ala Lys Asp Lys Phe 
            4580                4585                4590


Tyr Lys Val Gln Glu Ala Ile Leu Ala Arg Lys Glu Tyr Ala Ser Leu 
        4595                4600                4605


Ile Glu Leu Thr Thr Gln Ser Leu Ser Glu Leu Glu Ala Gln Phe Leu 
    4610                4615                4620


Arg Met Ser Lys Val Pro Thr Asp Leu Ala Val Glu Glu Ala Leu Ser 
4625                4630                4635                4640


Leu Gln Asp Gly Cys Arg Ala Ile Leu Asp Glu Val Ala Gly Leu Gly 
                4645                4650                4655


Glu Ala Val Asp Glu Leu Asn Gln Lys Lys Glu Gly Phe Arg Ser Thr 
            4660                4665                4670


Gly Gln Pro Trp Gln Pro Asp Lys Met Leu His Leu Val Thr Leu Tyr 
        4675                4680                4685


His Arg Leu Lys Arg Gln Thr Glu Gln Arg Val Ser Leu Leu Glu Asp 
    4690                4695                4700


Thr Thr Ser Ala Tyr Gln Glu His Glu Lys Met Cys Gln Gln Leu Glu 
4705                4710                4715                4720


Arg Gln Leu Lys Ser Val Lys Glu Glu Gln Ser Lys Val Asn Glu Glu 
                4725                4730                4735


Thr Leu Pro Ala Glu Glu Lys Leu Lys Met Tyr His Ser Leu Ala Gly 
            4740                4745                4750


Ser Leu Gln Asp Ser Gly Ile Val Leu Lys Arg Val Thr Ile His Leu 
        4755                4760                4765


Glu Asp Leu Ala Pro His Leu Asp Pro Leu Ala Tyr Glu Lys Ala Arg 
    4770                4775                4780


His Gln Ile Gln Ser Trp Gln Gly Glu Leu Lys Leu Leu Thr Ser Ala 
4785                4790                4795                4800


Ile Gly Glu Thr Val Thr Glu Cys Glu Ser Arg Met Val Gln Ser Ile 
                4805                4810                4815


Asp Phe Gln Thr Glu Met Ser Arg Ser Leu Asp Trp Leu Arg Arg Val 
            4820                4825                4830


Lys Ala Glu Leu Ser Gly Pro Val Tyr Leu Asp Leu Asn Leu Gln Asp 
        4835                4840                4845


Ile Gln Glu Glu Ile Arg Lys Ile Gln Ile His Gln Glu Glu Val Gln 
    4850                4855                4860


Ser Ser Leu Arg Ile Met Asn Ala Leu Ser His Lys Glu Lys Glu Lys 
4865                4870                4875                4880


Phe Thr Lys Ala Lys Glu Leu Ile Ser Ala Asp Leu Glu His Ser Leu 
                4885                4890                4895


Ala Glu Leu Ser Glu Leu Asp Gly Asp Ile Gln Glu Ala Leu Arg Thr 
            4900                4905                4910


Arg Gln Ala Thr Leu Thr Glu Ile Tyr Ser Gln Cys Gln Arg Tyr Tyr 
        4915                4920                4925


Gln Val Phe Gln Ala Ala Asn Asp Trp Leu Glu Asp Ala Gln Glu Leu 
    4930                4935                4940


Leu Gln Leu Ala Gly Asn Gly Leu Asp Val Glu Ser Ala Glu Glu Asn 
4945                4950                4955                4960


Leu Lys Ser His Met Glu Phe Phe Ser Thr Glu Asp Gln Phe His Ser 
                4965                4970                4975


Asn Leu Glu Glu Leu His Ser Leu Val Ala Thr Leu Asp Pro Leu Ile 
            4980                4985                4990


Lys Pro Thr Gly Lys Glu Asp Leu Glu Gln Lys Val Ala Ser Leu Glu 
        4995                5000                5005


Leu Arg Ser Gln Arg Met Ser Arg Asp Ser Gly Ala Gln Val Asp Leu 
    5010                5015                5020


Leu Gln Arg Cys Thr Ala Gln Trp His Asp Tyr Gln Lys Ala Arg Glu 
5025                5030                5035                5040


Glu Val Ile Glu Leu Met Asn Asp Thr Glu Lys Lys Leu Ser Glu Phe 
                5045                5050                5055


Ser Leu Leu Lys Thr Ser Ser Ser His Glu Ala Glu Glu Lys Leu Ser 
            5060                5065                5070


Glu His Lys Ala Leu Val Ser Val Val Asn Ser Phe His Glu Lys Ile 
        5075                5080                5085


Val Ala Leu Glu Glu Lys Ala Ser Gln Leu Glu Lys Thr Gly Asn Asp 
    5090                5095                5100


Ala Ser Lys Ala Thr Leu Ser Arg Ser Met Thr Thr Val Trp Gln Arg 
5105                5110                5115                5120


Trp Thr Arg Leu Arg Ala Val Ala Gln Asp Gln Glu Lys Ile Leu Glu 
                5125                5130                5135


Asp Ala Val Asp Glu Trp Thr Gly Phe Asn Asn Lys Val Lys Lys Ala 
            5140                5145                5150


Thr Glu Met Ile Asp Gln Leu Gln Asp Lys Leu Pro Gly Ser Ser Ala 
        5155                5160                5165


Glu Lys Ala Ser Lys Ala Glu Leu Leu Thr Leu Leu Glu Tyr His Asp 
    5170                5175                5180


Thr Phe Val Leu Glu Leu Glu Gln Gln Gln Ser Ala Leu Gly Met Leu 
5185                5190                5195                5200


Arg Gln Gln Thr Leu Ser Met Leu Gln Asp Gly Ala Ala Pro Thr Pro 
                5205                5210                5215


Gly Glu Glu Pro Pro Leu Met Gln Glu Ile Thr Ala Met Gln Asp Arg 
            5220                5225                5230


Cys Leu Asn Met Gln Glu Lys Val Lys Thr Asn Gly Lys Leu Val Lys 
        5235                5240                5245


Gln Glu Leu Lys Asp Arg Glu Met Val Glu Thr Gln Ile Asn Ser Val 
    5250                5255                5260


Lys Cys Trp Val Gln Glu Thr Lys Glu Tyr Leu Gly Asn Pro Thr Ile 
5265                5270                5275                5280


Glu Ile Asp Ala Gln Leu Glu Glu Leu Gln Ile Leu Leu Thr Glu Ala 
                5285                5290                5295


Thr Asn His Arg Gln Asn Ile Glu Lys Met Ala Glu Glu Gln Lys Glu 
            5300                5305                5310


Lys Tyr Leu Gly Leu Tyr Thr Ile Leu Pro Ser Glu Leu Ser Leu Gln 
        5315                5320                5325


Leu Ala Glu Val Ala Leu Asp Leu Lys Ile Arg Asp Gln Ile Gln Asp 
    5330                5335                5340


Lys Ile Lys Glu Val Glu Gln Ser Lys Ala Thr Ser Gln Glu Leu Ser 
5345                5350                5355                5360


Arg Gln Ile Gln Lys Leu Ala Lys Asp Leu Thr Thr Ile Leu Thr Lys 
                5365                5370                5375


Leu Lys Ala Lys Thr Asp Asn Val Val Gln Ala Lys Thr Asp Gln Lys 
            5380                5385                5390


Val Leu Gly Glu Glu Leu Asp Gly Cys Asn Ser Lys Leu Met Glu Leu 
        5395                5400                5405


Asp Ala Ala Val Gln Lys Phe Leu Glu Gln Asn Gly Gln Leu Gly Lys 
    5410                5415                5420


Pro Leu Ala Lys Lys Ile Gly Lys Leu Thr Glu Leu His Gln Gln Thr 
5425                5430                5435                5440


Ile Arg Gln Ala Glu Asn Arg Leu Ser Lys Leu Asn Gln Ala Ala Ser 
                5445                5450                5455


His Leu Glu Glu Tyr Asn Glu Met Leu Glu Leu Ile Leu Lys Trp Ile 
            5460                5465                5470


Glu Lys Ala Lys Val Leu Ala His Gly Thr Ile Ala Trp Asn Ser Ala 
        5475                5480                5485


Ser Gln Leu Arg Glu Gln Tyr Ile Leu His Gln Thr Leu Leu Glu Glu 
    5490                5495                5500


Ser Lys Glu Ile Asp Ser Glu Leu Glu Ala Met Thr Glu Lys Leu Gln 
5505                5510                5515                5520


Tyr Leu Thr Ser Val Tyr Cys Thr Glu Lys Met Ser Gln Gln Val Ala 
                5525                5530                5535


Glu Leu Gly Arg Glu Thr Glu Glu Leu Arg Gln Met Ile Lys Ile Arg 
            5540                5545                5550


Leu Gln Asn Leu Gln Asp Ala Ala Lys Asp Met Lys Lys Phe Glu Ala 
        5555                5560                5565


Glu Leu Lys Lys Leu Gln Ala Ala Leu Glu Gln Ala Gln Ala Thr Leu 
    5570                5575                5580


Thr Ser Pro Glu Val Gly Arg Leu Ser Leu Lys Glu Gln Leu Ser His 
5585                5590                5595                5600


Arg Gln His Leu Leu Ser Glu Met Glu Ser Leu Lys Pro Lys Val Gln 
                5605                5610                5615


Ala Val Gln Leu Cys Gln Ser Ala Leu Arg Ile Pro Glu Asp Val Val 
            5620                5625                5630


Ala Ser Leu Pro Leu Cys His Ala Ala Leu Arg Leu Gln Glu Glu Ala 
        5635                5640                5645


Ser Arg Leu Gln His Thr Ala Ile Gln Gln Cys Asn Ile Met Gln Ala 
    5650                5655                5660


Ala Val Val Gln Tyr Glu Gln Tyr Glu Gln Glu Met Lys His Leu Gln 
5665                5670                5675                5680


Gln Leu Ile Glu Gly Ala His Arg Glu Ile Glu Asp Lys Pro Val Ala 
                5685                5690                5695


Thr Ser Asn Ile Gln Glu Leu Gln Ala Gln Ile Ser Arg His Glu Glu 
            5700                5705                5710


Leu Ala Gln Lys Ile Lys Gly Tyr Gln Glu Gln Ile Ala Ser Leu Asn 
        5715                5720                5725


Ser Lys Cys Lys Met Leu Thr Met Lys Ala Lys His Ala Thr Met Leu 
    5730                5735                5740


Leu Thr Val Thr Glu Val Glu Gly Leu Ala Glu Gly Thr Glu Asp Leu 
5745                5750                5755                5760


Asp Gly Glu Leu Leu Pro Thr Pro Ser Ala His Pro Ser Val Val Met 
                5765                5770                5775


Met Thr Ala Gly Arg Cys His Thr Leu Leu Ser Pro Val Thr Glu Glu 
            5780                5785                5790


Ser Gly Glu Glu Gly Thr Asn Ser Glu Ile Ser Ser Pro Pro Ala Cys 
        5795                5800                5805


Arg Ser Pro Ser Pro Val Ala Asn Thr Asp Ala Ser Val Asn Gln Asp 
    5810                5815                5820


Ile Ala Tyr Tyr Gln Ala Leu Ser Ala Glu Arg Leu Gln Thr Asp Ala 
5825                5830                5835                5840


Ala Lys Ile His Pro Ser Thr Ser Ala Ser Gln Glu Phe Tyr Glu Pro 
                5845                5850                5855


Gly Leu Glu Pro Ser Ala Thr Ala Lys Leu Gly Asp Leu Gln Arg Ser 
            5860                5865                5870


Trp Glu Thr Leu Lys Asn Val Ile Ser Glu Lys Gln Arg Thr Leu Tyr 
        5875                5880                5885


Glu Ala Leu Glu Arg Gln Gln Lys Tyr Gln Asp Ser Leu Gln Ser Ile 
    5890                5895                5900


Ser Thr Lys Met Glu Ala Ile Glu Leu Lys Leu Ser Glu Ser Pro Glu 
5905                5910                5915                5920


Pro Gly Arg Ser Pro Glu Ser Gln Met Ala Glu His Gln Ala Leu Met 
                5925                5930                5935


Asp Glu Ile Leu Met Leu Gln Asp Glu Ile Asn Glu Leu Gln Ser Ser 
            5940                5945                5950


Leu Ala Glu Glu Leu Val Ser Glu Ser Cys Glu Ala Asp Pro Ala Glu 
        5955                5960                5965


Gln Leu Ala Leu Gln Ser Thr Leu Thr Val Leu Ala Glu Arg Met Ser 
    5970                5975                5980


Thr Ile Arg Met Lys Ala Ser Gly Lys Arg Gln Leu Leu Glu Glu Lys 
5985                5990                5995                6000


Leu Asn Asp Gln Leu Glu Glu Gln Arg Gln Glu Gln Ala Leu Gln Arg 
                6005                6010                6015


Tyr Arg Cys Glu Ala Asp Glu Leu Asp Ser Trp Leu Leu Ser Thr Lys 
            6020                6025                6030


Ala Thr Leu Asp Thr Ala Leu Ser Pro Pro Lys Glu Pro Met Asp Met 
        6035                6040                6045


Glu Ala Gln Leu Met Asp Cys Gln Asn Met Leu Val Glu Ile Glu Gln 
    6050                6055                6060


Lys Val Val Ala Leu Ser Glu Leu Ser Val His Asn Glu Asn Leu Leu 
6065                6070                6075                6080


Leu Glu Gly Lys Ala His Thr Lys Asp Glu Ala Glu Gln Leu Ala Gly 
                6085                6090                6095


Lys Leu Arg Arg Leu Lys Gly Ser Leu Leu Glu Leu Gln Arg Ala Leu 
            6100                6105                6110


His Asp Lys Gln Leu Asn Met Gln Gly Thr Ala Gln Glu Lys Glu Glu 
        6115                6120                6125


Ser Asp Val Asp Leu Thr Ala Thr Gln Ser Pro Gly Val Gln Glu Trp 
    6130                6135                6140


Leu Ala Gln Ala Arg Thr Thr Trp Thr Gln Gln Arg Gln Ser Ser Leu 
6145                6150                6155                6160


Gln Gln Gln Lys Glu Leu Glu Gln Glu Leu Ala Glu Gln Lys Ser Leu 
                6165                6170                6175


Leu Arg Ser Val Ala Ser Arg Gly Glu Glu Ile Leu Ile Gln His Ser 
            6180                6185                6190


Ala Ala Glu Thr Ser Gly Asp Ala Gly Glu Lys Pro Asp Val Leu Ser 
        6195                6200                6205


Gln Glu Leu Gly Met Glu Gly Glu Lys Ser Ser Ala Glu Asp Gln Met 
    6210                6215                6220


Arg Met Lys Trp Glu Ser Leu His Gln Glu Phe Ser Thr Lys Gln Lys 
6225                6230                6235                6240


Leu Leu Gln Asn Val Leu Glu Gln Glu Gln Glu Gln Val Leu Tyr Ser 
                6245                6250                6255


Arg Pro Asn Arg Leu Leu Ser Gly Val Pro Leu Tyr Lys Gly Asp Val 
            6260                6265                6270


Pro Thr Gln Asp Lys Ser Ala Val Thr Ser Leu Leu Asp Gly Leu Asn 
        6275                6280                6285


Gln Ala Phe Glu Glu Val Ser Ser Gln Ser Gly Gly Ala Lys Arg Gln 
    6290                6295                6300


Ser Ile His Leu Glu Gln Lys Leu Tyr Asp Gly Val Ser Ala Thr Ser 
6305                6310                6315                6320


Thr Trp Leu Asp Asp Val Glu Glu Arg Leu Phe Val Ala Thr Ala Leu 
                6325                6330                6335


Leu Pro Glu Glu Thr Glu Thr Cys Leu Phe Asn Gln Glu Ile Leu Ala 
            6340                6345                6350


Lys Asp Ile Lys Glu Met Ser Glu Glu Met Asp Lys Asn Lys Asn Leu 
        6355                6360                6365


Phe Ser Gln Ala Phe Pro Glu Asn Gly Asp Asn Arg Asp Val Ile Glu 
    6370                6375                6380


Asp Thr Leu Gly Cys Leu Leu Gly Arg Leu Ser Leu Leu Asp Ser Val 
6385                6390                6395                6400


Val Asn Gln Arg Cys His Gln Met Lys Glu Arg Leu Gln Gln Ile Leu 
                6405                6410                6415


Asn Phe Gln Asn Asp Leu Lys Val Leu Phe Thr Ser Leu Ala Asp Asn 
            6420                6425                6430


Lys Tyr Ile Ile Leu Gln Lys Leu Ala Asn Val Phe Glu Gln Pro Val 
        6435                6440                6445


Ala Glu Gln Ile Glu Ala Ile Gln Gln Ala Glu Asp Gly Leu Lys Glu 
    6450                6455                6460


Phe Asp Ala Gly Ile Ile Glu Leu Lys Arg Arg Gly Asp Lys Leu Gln 
6465                6470                6475                6480


Val Glu Gln Pro Ser Met Gln Glu Leu Ser Lys Leu Gln Asp Met Tyr 
                6485                6490                6495


Asp Glu Leu Met Met Ile Ile Gly Ser Arg Arg Ser Gly Leu Asn Gln 
            6500                6505                6510


Asn Leu Thr Leu Lys Ser Gln Tyr Glu Arg Ala Leu Gln Asp Leu Ala 
        6515                6520                6525


Asp Leu Leu Glu Thr Gly Gln Glu Lys Met Ala Gly Asp Gln Lys Ile 
    6530                6535                6540


Ile Val Ser Ser Lys Glu Glu Ile Gln Gln Leu Leu Asp Lys His Lys 
6545                6550                6555                6560


Glu Tyr Phe Gln Gly Leu Glu Ser His Met Ile Leu Thr Glu Thr Leu 
                6565                6570                6575


Phe Arg Lys Ile Ile Ser Phe Ala Val Gln Lys Glu Thr Gln Phe His 
            6580                6585                6590


Thr Glu Leu Met Ala Gln Ala Ser Ala Val Leu Lys Arg Ala His Lys 
        6595                6600                6605


Arg Gly Val Glu Leu Glu Tyr Ile Leu Glu Thr Trp Ser His Leu Asp 
    6610                6615                6620


Glu Asp Gln Gln Glu Leu Ser Arg Gln Leu Glu Val Val Glu Ser Ser 
6625                6630                6635                6640


Ile Pro Ser Val Gly Leu Val Glu Glu Asn Glu Asp Arg Leu Ile Asp 
                6645                6650                6655


Arg Ile Thr Leu Tyr Gln His Leu Lys Ser Ser Leu Asn Glu Tyr Gln 
            6660                6665                6670


Pro Lys Leu Tyr Gln Val Leu Asp Asp Gly Lys Arg Leu Leu Ile Ser 
        6675                6680                6685


Ile Ser Cys Ser Asp Leu Glu Ser Gln Leu Asn Gln Leu Gly Glu Cys 
    6690                6695                6700


Trp Leu Ser Asn Thr Asn Lys Met Ser Lys Glu Leu His Arg Leu Glu 
6705                6710                6715                6720


Thr Ile Leu Lys His Trp Thr Arg Tyr Gln Ser Glu Ser Ala Asp Leu 
                6725                6730                6735


Ile His Trp Leu Gln Ser Ala Lys Asp Arg Leu Glu Phe Trp Thr Gln 
            6740                6745                6750


Gln Ser Val Thr Val Pro Gln Glu Leu Glu Met Val Arg Asp His Leu 
        6755                6760                6765


Asn Ala Phe Leu Glu Phe Ser Lys Glu Val Asp Ala Gln Ser Ser Leu 
    6770                6775                6780


Lys Ser Ser Val Leu Ser Thr Gly Asn Gln Leu Leu Arg Leu Lys Lys 
6785                6790                6795                6800


Val Asp Thr Ala Thr Leu Arg Ser Glu Leu Ser Arg Ile Asp Ser Gln 
                6805                6810                6815


Trp Thr Asp Leu Leu Thr Asn Ile Pro Ala Val Gln Glu Lys Leu His 
            6820                6825                6830


Gln Leu Gln Met Asp Lys Leu Pro Ser Arg His Ala Ile Ser Glu Val 
        6835                6840                6845


Met Ser Trp Ile Ser Leu Met Glu Asn Val Ile Gln Lys Asp Glu Asp 
    6850                6855                6860


Asn Ile Lys Asn Ser Ile Gly Tyr Lys Ala Ile His Glu Tyr Leu Gln 
6865                6870                6875                6880


Lys Tyr Lys Gly Phe Lys Ile Asp Ile Asn Cys Lys Gln Leu Thr Val 
                6885                6890                6895


Asp Phe Val Asn Gln Ser Val Leu Gln Ile Ser Ser Gln Asp Val Glu 
            6900                6905                6910


Ser Lys Arg Ser Asp Lys Thr Asp Phe Ala Glu Gln Leu Gly Ala Met 
        6915                6920                6925


Asn Lys Ser Trp Gln Ile Leu Gln Gly Leu Val Thr Glu Lys Ile Gln 
    6930                6935                6940


Leu Leu Glu Gly Leu Leu Glu Ser Trp Ser Glu Tyr Glu Asn Asn Val 
6945                6950                6955                6960


Gln Cys Leu Lys Thr Trp Phe Glu Thr Gln Glu Lys Arg Leu Lys Gln 
                6965                6970                6975


Gln His Arg Ile Gly Asp Gln Ala Ser Val Gln Asn Ala Leu Lys Asp 
            6980                6985                6990


Cys Gln Asp Leu Glu Asp Leu Ile Lys Ala Lys Glu Lys Glu Val Glu 
        6995                7000                7005


Lys Ile Glu Gln Asn Gly Leu Ala Leu Ile Gln Asn Lys Lys Glu Asp 
    7010                7015                7020


Val Ser Ser Ile Val Met Ser Thr Leu Arg Glu Leu Gly Gln Thr Trp 
7025                7030                7035                7040


Ala Asn Leu Asp His Met Val Gly Gln Leu Lys Ile Leu Leu Lys Ser 
                7045                7050                7055


Val Leu Asp Gln Trp Ser Ser His Lys Val Ala Phe Asp Lys Ile Asn 
            7060                7065                7070


Ser Tyr Leu Met Glu Ala Arg Tyr Ser Leu Ser Arg Phe Arg Leu Leu 
        7075                7080                7085


Thr Gly Ser Leu Glu Ala Val Gln Val Gln Val Asp Asn Leu Gln Asn 
    7090                7095                7100


Leu Gln Asp Asp Leu Glu Lys Gln Glu Arg Ser Leu Gln Lys Phe Gly 
7105                7110                7115                7120


Ser Ile Thr Asn Gln Leu Leu Lys Glu Cys His Pro Pro Val Thr Glu 
                7125                7130                7135


Thr Leu Thr Asn Thr Leu Lys Glu Val Asn Met Arg Trp Asn Asn Leu 
            7140                7145                7150


Leu Glu Glu Ile Ala Glu Gln Leu Gln Ser Ser Lys Ala Leu Leu Gln 
        7155                7160                7165


Leu Trp Gln Arg Tyr Lys Asp Tyr Ser Lys Gln Cys Ala Ser Thr Val 
    7170                7175                7180


Gln Gln Gln Glu Asp Arg Thr Asn Glu Leu Leu Lys Ala Ala Thr Asn 
7185                7190                7195                7200


Lys Asp Ile Ala Asp Asp Glu Val Ala Thr Trp Ile Gln Asp Cys Asn 
                7205                7210                7215


Asp Leu Leu Lys Gly Leu Gly Thr Val Lys Asp Ser Leu Phe Phe Leu 
            7220                7225                7230


His Glu Leu Gly Glu Gln Leu Lys Gln Gln Val Asp Ala Ser Ala Ala 
        7235                7240                7245


Ser Ala Ile Gln Ser Asp Gln Leu Ser Leu Ser Gln His Leu Cys Ala 
    7250                7255                7260


Leu Glu Gln Ala Leu Cys Lys Gln Gln Thr Ser Leu Gln Ala Gly Val 
7265                7270                7275                7280


Leu Asp Tyr Glu Thr Phe Ala Lys Ser Leu Glu Ala Leu Glu Ala Trp 
                7285                7290                7295


Ile Val Glu Ala Glu Glu Ile Leu Gln Gly Gln Asp Pro Ser His Ser 
            7300                7305                7310


Ser Asp Leu Ser Thr Ile Gln Glu Arg Met Glu Glu Leu Lys Gly Gln 
        7315                7320                7325


Met Leu Lys Phe Ser Ser Met Ala Pro Asp Leu Asp Arg Leu Asn Glu 
    7330                7335                7340


Leu Gly Tyr Arg Leu Pro Leu Asn Asp Lys Glu Ile Lys Arg Met Gln 
7345                7350                7355                7360


Asn Leu Asn Arg His Trp Ser Leu Ile Ser Ser Gln Thr Thr Glu Arg 
                7365                7370                7375


Phe Ser Lys Leu Gln Ser Phe Leu Leu Gln His Gln Thr Phe Leu Glu 
            7380                7385                7390


Lys Cys Glu Thr Trp Met Glu Phe Leu Val Gln Thr Glu Gln Lys Leu 
        7395                7400                7405


Ala Val Glu Ile Ser Gly Asn Tyr Gln His Leu Leu Glu Gln Gln Arg 
    7410                7415                7420


Ala His Glu Leu Phe Gln Ala Glu Met Phe Ser Arg Gln Gln Ile Leu 
7425                7430                7435                7440


His Ser Ile Ile Ile Asp Gly Gln Arg Leu Leu Glu Gln Gly Gln Val 
                7445                7450                7455


Asp Asp Arg Asp Glu Phe Asn Leu Lys Leu Thr Leu Leu Ser Asn Gln 
            7460                7465                7470


Trp Gln Gly Val Ile Arg Arg Ala Gln Gln Arg Arg Gly Ile Ile Asp 
        7475                7480                7485


Ser Gln Ile Arg Gln Trp Gln Arg Tyr Arg Glu Met Ala Glu Lys Leu 
    7490                7495                7500


Arg Lys Trp Leu Val Glu Val Ser Tyr Leu Pro Met Ser Gly Leu Gly 
7505                7510                7515                7520


Ser Val Pro Ile Pro Leu Gln Gln Ala Arg Thr Leu Phe Asp Glu Val 
                7525                7530                7535


Gln Phe Lys Glu Lys Val Phe Leu Arg Gln Gln Gly Ser Tyr Ile Leu 
            7540                7545                7550


Thr Val Glu Ala Gly Lys Gln Leu Leu Leu Ser Ala Asp Ser Gly Ala 
        7555                7560                7565


Glu Ala Ala Leu Gln Ala Glu Leu Ala Glu Ile Gln Glu Lys Trp Lys 
    7570                7575                7580


Ser Ala Ser Met Arg Leu Glu Glu Gln Lys Lys Lys Leu Ala Phe Leu 
7585                7590                7595                7600


Leu Lys Asp Trp Glu Lys Cys Glu Lys Gly Ile Ala Asp Ser Leu Glu 
                7605                7610                7615


Lys Leu Arg Thr Phe Lys Lys Lys Leu Ser Gln Ser Leu Pro Asp His 
            7620                7625                7630


His Glu Glu Leu His Ala Glu Gln Met Arg Cys Lys Glu Leu Glu Asn 
        7635                7640                7645


Ala Val Gly Ser Trp Thr Asp Asp Leu Thr Gln Leu Ser Leu Leu Lys 
    7650                7655                7660


Asp Thr Leu Ser Ala Tyr Ile Ser Ala Asp Asp Ile Ser Ile Leu Asn 
7665                7670                7675                7680


Glu Arg Val Glu Leu Leu Gln Arg Gln Trp Glu Glu Leu Cys His Gln 
                7685                7690                7695


Leu Ser Leu Arg Arg Gln Gln Ile Gly Glu Arg Leu Asn Glu Trp Ala 
            7700                7705                7710


Val Phe Ser Glu Lys Asn Lys Glu Leu Cys Glu Trp Leu Thr Gln Met 
        7715                7720                7725


Glu Ser Lys Val Ser Gln Asn Gly Asp Ile Leu Ile Glu Glu Met Ile 
    7730                7735                7740


Glu Lys Leu Lys Lys Asp Tyr Gln Glu Glu Ile Ala Ile Ala Gln Glu 
7745                7750                7755                7760


Asn Lys Ile Gln Leu Gln Gln Met Gly Glu Arg Leu Ala Lys Ala Ser 
                7765                7770                7775


His Glu Ser Lys Ala Ser Glu Ile Glu Tyr Lys Leu Gly Lys Val Asn 
            7780                7785                7790


Asp Arg Trp Gln His Leu Leu Asp Leu Ile Ala Ala Arg Val Lys Lys 
        7795                7800                7805


Leu Lys Glu Thr Leu Val Ala Val Gln Gln Leu Asp Lys Asn Met Ser 
    7810                7815                7820


Ser Leu Arg Thr Trp Leu Ala His Ile Glu Ser Glu Leu Ala Lys Pro 
7825                7830                7835                7840


Ile Val Tyr Asp Ser Cys Asn Ser Glu Glu Ile Gln Arg Lys Leu Asn 
                7845                7850                7855


Glu Gln Gln Glu Leu Gln Arg Asp Ile Glu Lys His Ser Thr Gly Val 
            7860                7865                7870


Ala Ser Val Leu Asn Leu Cys Glu Val Leu Leu His Asp Cys Asp Ala 
        7875                7880                7885


Cys Ala Thr Asp Ala Glu Cys Asp Ser Ile Gln Gln Ala Thr Arg Asn 
    7890                7895                7900


Leu Asp Arg Arg Trp Arg Asn Ile Cys Ala Met Ser Met Glu Arg Arg 
7905                7910                7915                7920


Leu Lys Ile Glu Glu Thr Trp Arg Leu Trp Gln Lys Phe Leu Asp Asp 
                7925                7930                7935


Tyr Ser Arg Phe Glu Asp Trp Leu Lys Ser Ser Glu Arg Thr Ala Ala 
            7940                7945                7950


Phe Pro Ser Ser Ser Gly Val Ile Tyr Thr Val Ala Lys Glu Glu Leu 
        7955                7960                7965


Lys Lys Phe Glu Ala Phe Gln Arg Gln Val His Glu Cys Leu Thr Gln 
    7970                7975                7980


Leu Glu Leu Ile Asn Lys Gln Tyr Arg Arg Leu Ala Arg Glu Asn Arg 
7985                7990                7995                8000


Thr Asp Ser Ala Cys Ser Leu Lys Gln Met Val His Glu Gly Asn Gln 
                8005                8010                8015


Arg Trp Asp Asn Leu Gln Lys Arg Val Thr Ser Ile Leu Arg Arg Leu 
            8020                8025                8030


Lys His Phe Ile Gly Gln Arg Glu Glu Phe Glu Thr Ala Arg Asp Ser 
        8035                8040                8045


Ile Leu Val Trp Leu Thr Glu Met Asp Leu Gln Leu Thr Asn Ile Glu 
    8050                8055                8060


His Phe Ser Glu Cys Asp Val Gln Ala Lys Ile Lys Gln Leu Lys Ala 
8065                8070                8075                8080


Phe Gln Gln Glu Ile Ser Leu Asn His Asn Lys Ile Glu Gln Ile Ile 
                8085                8090                8095


Ala Gln Gly Glu Gln Leu Ile Glu Lys Ser Glu Pro Leu Asp Ala Ala 
            8100                8105                8110


Ile Ile Glu Glu Glu Leu Asp Glu Leu Arg Arg Tyr Cys Gln Glu Val 
        8115                8120                8125


Phe Gly Arg Val Glu Arg Tyr His Lys Lys Leu Ile Arg Leu Pro Leu 
    8130                8135                8140


Pro Asp Asp Glu His Asp Leu Ser Asp Arg Glu Leu Glu Leu Glu Asp 
8145                8150                8155                8160


Ser Ala Ala Leu Ser Asp Leu His Trp His Asp Arg Ser Ala Asp Ser 
                8165                8170                8175


Leu Leu Ser Pro Gln Pro Ser Ser Asn Leu Ser Leu Ser Leu Ala Gln 
            8180                8185                8190


Pro Leu Arg Ser Glu Arg Ser Gly Arg Asp Thr Pro Ala Ser Val Asp 
        8195                8200                8205


Ser Ile Pro Leu Glu Trp Asp His Asp Tyr Asp Leu Ser Arg Asp Leu 
    8210                8215                8220


Glu Ser Ala Met Ser Arg Ala Leu Pro Ser Glu Asp Glu Glu Gly Gln 
8225                8230                8235                8240


Asp Asp Lys Asp Phe Tyr Leu Arg Gly Ala Val Gly Leu Ser Asp Val 
                8245                8250                8255


Met Ile Pro Glu Ser Pro Glu Ala Tyr Val Lys Leu Thr Glu Asn Ala 
            8260                8265                8270


Ile Lys Asn Thr Ser Gly Asp His Ser Ala Leu Glu Ser Gln Ile Arg 
        8275                8280                8285


Gln Leu Gly Lys Ala Leu Asp Asp Ser Arg Phe Gln Ile Gln Gln Thr 
    8290                8295                8300


Glu Asn Ile Ile Arg Ser Lys Thr Pro Thr Gly Pro Glu Leu Asp Thr 
8305                8310                8315                8320


Ser Tyr Lys Gly Tyr Met Lys Leu Leu Gly Glu Cys Ser Ser Ser Ile 
                8325                8330                8335


Asp Ser Val Lys Arg Leu Glu His Lys Leu Lys Glu Glu Glu Glu Ser 
            8340                8345                8350


Leu Pro Gly Phe Val Asn Leu His Ser Thr Glu Thr Gln Thr Ala Gly 
        8355                8360                8365


Val Ile Asp Arg Trp Glu Leu Leu Gln Ala Gln Ala Leu Ser Lys Glu 
    8370                8375                8380


Leu Arg Met Lys Gln Asn Leu Gln Lys Trp Gln Gln Phe Asn Ser Asp 
8385                8390                8395                8400


Leu Asn Ser Ile Trp Ala Trp Leu Gly Asp Thr Glu Glu Glu Leu Glu 
                8405                8410                8415


Gln Leu Gln Arg Leu Glu Leu Ser Thr Asp Ile Gln Thr Ile Glu Leu 
            8420                8425                8430


Gln Ile Lys Lys Leu Lys Glu Leu Gln Lys Ala Val Asp His Arg Lys 
        8435                8440                8445


Ala Ile Ile Leu Ser Ile Asn Leu Cys Ser Pro Glu Phe Thr Gln Ala 
    8450                8455                8460


Asp Ser Lys Glu Ser Arg Asp Leu Gln Asp Arg Leu Ser Gln Met Asn 
8465                8470                8475                8480


Gly Arg Trp Asp Arg Val Cys Ser Leu Leu Glu Glu Trp Arg Gly Leu 
                8485                8490                8495


Leu Gln Asp Ala Leu Met Gln Cys Gln Gly Phe His Glu Met Ser His 
            8500                8505                8510


Gly Leu Leu Leu Met Leu Glu Asn Ile Asp Arg Arg Lys Asn Glu Ile 
        8515                8520                8525


Val Pro Ile Asp Ser Asn Leu Asp Ala Glu Ile Leu Gln Asp His His 
    8530                8535                8540


Lys Gln Leu Met Gln Ile Lys His Glu Leu Leu Glu Ser Gln Leu Arg 
8545                8550                8555                8560


Val Ala Ser Leu Gln Asp Met Ser Cys Gln Leu Leu Val Asn Ala Glu 
                8565                8570                8575


Gly Thr Asp Cys Leu Glu Ala Lys Glu Lys Val His Val Ile Gly Asn 
            8580                8585                8590


Arg Leu Lys Leu Leu Leu Lys Glu Val Ser Arg His Ile Lys Glu Leu 
        8595                8600                8605


Glu Lys Leu Leu Asp Val Ser Ser Ser Gln Gln Asp Leu Ser Ser Trp 
    8610                8615                8620


Ser Ser Ala Asp Glu Leu Asp Thr Ser Gly Ser Val Ser Pro Thr Ser 
8625                8630                8635                8640


Gly Arg Ser Thr Pro Asn Arg Gln Lys Thr Pro Arg Gly Lys Cys Ser 
                8645                8650                8655


Leu Ser Gln Pro Gly Pro Ser Val Ser Ser Pro His Ser Arg Ser Thr 
            8660                8665                8670


Lys Gly Gly Ser Asp Ser Ser Leu Ser Glu Pro Gly Pro Gly Arg Ser 
        8675                8680                8685


Gly Arg Gly Phe Leu Phe Arg Val Leu Arg Ala Ala Leu Pro Leu Gln 
    8690                8695                8700


Leu Leu Leu Leu Leu Leu Ile Gly Leu Ala Cys Leu Val Pro Met Ser 
8705                8710                8715                8720


Glu Glu Asp Tyr Ser Cys Ala Leu Ser Asn Asn Phe Ala Arg Ser Phe 
                8725                8730                8735


His Pro Met Leu Arg Tyr Thr Asn Gly Pro Pro Pro Leu 
            8740                8745


<210>  3418
<211>  27748
<212>  DNA
<213>  Homo sapiens

<400>  3418
cccgggcagt ggaaaccgtg ggcaaaagtt agctggcagg acagcgcagc tcctccaggc     60

agcggaggca gcgcgtcccg gctctcaggg acatttcctt cccacctcga cccccgggag    120

gtggtcccgg tataaaggct cgctgagcgg gtgggtcaca gcacagcttt gcagctgcgg    180

agaaacgccc aaggccgtgc atctccagga gggcggctgg gctcccgcag tcctgcagac    240

cgcgcccgat cccggcgaca gggcgggcgg acagccgcgc atccccgggg tcccgccgag    300

cctgggcgca gagagccggg aggaagcgtt cgctcgcttc gccttgctgc tgggaaactg    360

aacgaggccg agagagaagg ttcttgagtt catgtaagag gacagtctta aaacggaaga    420

agaaaaagaa gcagttcagt ctttgggaga gctgcctcct tgttgagtgc tgcaaaggcc    480

tggaattcat ttatgacaga atagatctag aaaagtccaa gcatgttttc tagagtggtg    540

tagccctgtg ctgcctccag tgaagagtct cttggtgttg gcttcgtgct tccggaggga    600

ccatggcaac ctccagaggg gcctcccggt gtcctcggga tatcgccaat gtgatgcaga    660

ggctgcaaga tgagcaagag atagtacaaa aacgaacttt cacaaaatgg atcaactctc    720

atctggccaa gcggaaacct ccaatggtgg tggacgatct ttttgaagac atgaaagatg    780

gtgttaaact gcttgccctt ctggaggtcc tgtctgggca gaaactgcct tgtgaacaag    840

gacgccggat gaagcgaatc catgctgtgg ctaacattgg cacggcactc aagttcctcg    900

aaggaagaaa gattaaatta gtcaacatta actccaccga tatagctgat ggccgaccct    960

caatagttct tggattgatg tggaccatta ttctatattt ccagattgaa gagttgacca   1020

gcaacctgcc ccagctccag tctttgtcca gcagcgcatc ctccgtggac agcatagtta   1080

gctctgagac tcccagccca ccaagtaaac ggaaggtgac caccaagatc caaggaaatg   1140

ctaagaaggc tttattaaag tgggttcagt acacagctgg caagcagact ggaatagaag   1200

taaaagattt tgggaagagt tggagaagcg gggttgcctt tcattcagtt attcatgcca   1260

ttcgaccgga attggtggac ttggagacag tgaaaggcag atccaaccga gaaaatttgg   1320

aggatgcttt cactatcgcc gaaacagaac tggggatccc aagactgcta gatcctgaag   1380

acgttgatgt ggataaacca gatgagaaat ctattatgac ctatgtagcc cagtttctga   1440

aacattatcc tgacatccac aatgcaagca ctgatgggca agaggatgat gaaatacttc   1500

caggtttccc atcttttgca aattctgtac aaaattttaa gagagaagac agagtaattt   1560

ttaaggaaat gaaagtttgg atagaacaat ttgagagaga tttgacaaga gcacagatgg   1620

tggaatcaaa tttacaggat aaatatcagt catttaagca cttcagagtt caatatgaaa   1680

tgaagaggaa acagattgaa catttaatac aaccattaca cagagacggt aaattgtcac   1740

ttgaccaagc attggtaaaa caatcttggg atagagtgac ctccaggctc tttgactggc   1800

atatacagct tgataaatct cttcctgcac ctctgggcac cataggtgcc tggctgtaca   1860

gagcggaggt ggccctgaga gaggaaataa ccgttcaaca ggtccacgag gaaacagcaa   1920

acacgataca acggaaactt gagcaacata aggatctgct tcaaaacacg gatgcccaca   1980

aaagagcatt ccatgaaatc taccggacca ggtctgttaa cgggattcca gtgccacctg   2040

atcaattaga ggacatggcc gagaggtttc attttgtttc ctccacatca gagctacacc   2100

taatgaaaat ggaattttta gaattaaagt accgtctgct ctcactgctg gttcttgcag   2160

agtcaaagct gaagtcttgg atcattaagt acgggaggag agagtcagtg gagcagcttc   2220

tacaaaacta cgtgtctttt atagaaaata gcaagttctt tgaacaatat gaggtgacat   2280

accagatctt gaaacagaca gctgagatgt atgtcaaagc agatggttca gtggaagaag   2340

ctgagaatgt gatgaaattc atgaatgaaa ccaccgctca gtggaggaat ctctcagtag   2400

aagtgaggag tgtgaggagc atgctggaag aagtgatctc taactgggat cgctatggca   2460

atacagtggc tagtctgcaa gcctggctag aggatgctga aaaaatgctc aatcaatcag   2520

aaaatgccaa aaaggatttt tttcgaaatt tacctcattg gattcagcag catactgcca   2580

tgaacgatgc tggcaatttt ctaattgaaa cctgtgatga gatggtttcc cgtgacctga   2640

agcagcaatt actgttgcta aatgggcggt ggagggagtt gtttatggaa gtcaagcaat   2700

atgctcaagc tgatgagatg gacagaatga agaaggaata cacagactgt gttgttaccc   2760

tgtctgcttt tgcaacggaa gcccataaga aactttctga acccttagaa gtctctttta   2820

tgaatgtcaa gctattaatt caagacttgg aggatattga gcagagggtg cctgtgatgg   2880

atgcccaata caagataatt acaaagacag cacacctcat taccaaagaa agcccccaag   2940

aagaaggaaa agaaatgttt gcgaccatgt caaagctcaa agagcagcta accaaggtca   3000

aagaatgtta ctccccactc ctttatgagt ctcagcagct gttgattccg ttggaggaat   3060

tagaaaagca gatgacgtcc ttttatgact cacttgggaa aatcaatgaa attatcacag   3120

ttcttgagcg tgaggcacaa tcgagtgccc tttttaaaca aaaacatcag gaactgttag   3180

cttgtcaaga aaactgtaag aaaaccttga cacttattga gaaaggcagt caaagtgttc   3240

aaaagtttgt gaccttgagc aacgtgttaa agcattttga tcagacgagg ctacaaagac   3300

agattgcaga tattcatgtt gcttttcaga gtatggtaaa gaaaactgga gattggaaga   3360

agcatgtgga aaccaacagt cgcttgatga agaagtttga ggagtctcga gcagagttgg   3420

agaaggtact gcggattgct caggagggcc tggaggaaaa gggggatcca gaggagctcc   3480

tgcggagaca cactgagttt ttcagtcagc tggatcagag ggtgctcaat gctttcctga   3540

aagcttgtga tgaactcacc gacatccttc cagagcagga gcagcagggg ctgcaggaag   3600

ctgttcgaaa gctccacaaa caatggaagg atcttcaagg agaagcccct tatcatttgc   3660

ttcatctgaa gattgatgtg gagaagaata ggttcttagc ctctgtagaa gaatgcagaa   3720

ctgagctgga tcgagagacc aagctgatgc cccaggaagg cagtgaaaag ataattaaag   3780

agcacagggt tttcttcagt gacaaaggtc ctcatcatct ctgtgagaaa aggttacagc   3840

tcatcgagga actctgtgtg aaactcccag tgcgggaccc agtaagggac acacctggaa   3900

cctgtcacgt gactctcaaa gagctcagag ctgccattga cagcacctac aggaagctca   3960

tggaagaccc agacaagtgg aaggactaca ctagcagatt ctctgagttc tcatcttgga   4020

tatctacaaa tgagacacaa ttaaagggga tcaagggtga ggccatcgat actgccaacc   4080

acggagaggt taaacgtgcc gttgaagaga tcagaaatgg tgttaccaaa aggggtgaga   4140

ccctcagctg gctgaaatcc aggctgaaag ttttgacaga agtttcttct gagaatgaag   4200

cccaaaagca gggagatgag ctggcaaaat tatccagctc tttcaaggct cttgtgacgc   4260

tgctgtcaga ggttgaaaag atgctaagca attttgggga ctgtgtccag tacaaagaaa   4320

tagtcaaaaa ttctctcgaa gaattaattt ctggctctaa agaagtccag gaacaagctg   4380

agaagatctt ggatactgaa aatctgtttg aagcacagca gttacttctt catcaccagc   4440

aaaagacaaa gcggatctca gcaaagaaga gagatgtgca gcagcagatc gcgcaggcgc   4500

agcagggaga aggggggctg cctgaccgag gccacgagga gctgcggaag ctggagagca   4560

cactggatgg cctggagcgc agccgggaga ggcaggaacg ccgcatccag gtcacattaa   4620

gaaaatggga gcgatttgaa acaaacaaag aaacagtagt aagatacctt tttcaaacag   4680

gttccagtca tgaacgcttc ttgagtttta gcagtttgga aagtttatct tcagaactgg   4740

aacaaacaaa ggagttttct aaacggacag aaagtattgc agtccaggct gagaaccttg   4800

taaaggaagc ttcagagata ccgcttgggc cccaaaataa gcagctgctt caacagcagg   4860

ccaagtcaat caaagaacaa gtcaaaaaat tagaagacac gcttgaagaa gatattaaaa   4920

ccatggaaat ggtgaaaacc aagtgggatc attttggcag taattttgag actctgtccg   4980

tctggataac tgagaaagaa aaagaactca atgccttgga aacttcgtca tctgccatgg   5040

acatgcaaat cagccaaatt aaggtcacaa ttcaggaaat agaaagtaag ctcagcagca   5100

ttgtaggatt agaagaagaa gcccagtctt ttgctcagtt tgttaccact ggagaatctg   5160

ctcgaattaa agccaagttg acacaaataa gaagatacgg ggaagagctt cgagagcatg   5220

cacagtgtct ggaaggaaca atcctgggac atttatctca gcagcaaaag tttgaagaga   5280

accttagaaa gatccagcaa tctgtgtctg aatttgaaga taaacttgct gttccaatta   5340

aaatatgttc ttcagctaca gaaacataca aagttcttca agaacatatg gatctctgcc   5400

aggccctgga gtcactgagc agcgcgatca ctgccttctc agccagtgcc aggaaggttg   5460

tgaacagaga ttcctgtgtt caggaggctg cggctctaca gcagcaatac gaggacatcc   5520

taaggagggc gaaggagaga cagacggcgc tggagaatct gctggcccac tggcagaggc   5580

tagagaaaga actatcatcc tttttgacct ggttagagcg gggtgaagct aaagccagtt   5640

ccccagaaat ggacatttct gcagacagag tcaaagtgga aggtgaactt cagttaatac   5700

aggcactgca aaatgaagtt gtatcccagg cctcattcta tagcaaactt ttgcaattga   5760

aggaatcatt gttctcagta gcctccaaag atgatgtgaa aatgatgaaa ctacatttgg   5820

agcagttgga tgagagatgg agagatttac cacagatcat taacaaaagg attaattttc   5880

ttcagtctgt ggttgctgaa caccagcaat ttgatgagct gctgctttcc ttttctgtct   5940

ggattaaact gtttctcagt gaattacaaa ctacctctga gattagcata atggaccatc   6000

aagtagccct tactcggcat aaggaccacg cagcagaagt agagagcaaa aagggcgaat   6060

tgcagagtct gcagggtcac ttagcaaagt tgggttctct gggccgtgct gaggacctcc   6120

acctcctgca gggaaaggct gaggactgct tccagctgtt tgaggaggcc agccaggttg   6180

tggagaggcg gcagcttgcc ctgtcccatt tggcagaatt cctccagagc catgcctctc   6240

tgtccggcat tctccgccag ctgaggcaaa cagtggaagc aaccaacagt atgaataaga   6300

acgagtctga tttgatagaa aaggacctca atgatgctct tcaaaatgct aaagcattag   6360

aatctgctgc cgtcagtctg gatggcattc tttccaaagc ccaataccat ctgaaaatcg   6420

ggagctctga gcaaaggact tcctgcagag ccacggctga tcagctctgt ggagaggtag   6480

agaggatcca gaaccttctg ggaaccaagc agagtgaggc agatgctctg gcagtgttga   6540

aaaaagcatt ccaagaccag aaagaggagc ttctgaaaag cattgaggac attgaagaaa   6600

ggactgacaa agagcgattg aaagaaccta cccgccaagc tcttcagcag aggttaagag   6660

tgtttaatca gctagaagat gaattgaatt ctcacgagca tgaactatgt tggttgaaag   6720

acaaagccaa gcaaattgcc cagaaagatg tagcttttgc acctgaagtt gacagggaga   6780

taaaccgctt agaggtcacc tgggatgata ccaaaagact aattcatgaa aatcagggtc   6840

agtgctgtgg acttattgac ttaatgagag aatatcagaa cctgaaatca gctgtatcta   6900

aagtcttaga aaatgccagc agtgtgattg taaccagaac taccataaaa gatcaggagg   6960

atcttaaatg ggctttttcc aagcatgaaa ctgccaagaa caaaatgaat tacaaacaga   7020

aagacttgga taactttacc agcaaaggaa aacacttgtt atctgagctg aagaaaattc   7080

acagtagtga tttcagcttg gtgaaaacag acatggagag caccgtggac aaatggctgg   7140

atgtatcaga gaaacttgaa gaaaacatgg ataggctgag agtaagcctg tccatttggg   7200

atgatgtact gtcaactaga gatgagattg agggatggtc aaacaactgc gttccacaga   7260

tggcagaaaa catcagcaac ctggataacc acctcagagc tgaagaactg cttaaagaat   7320

ttgagtctga agttaaaaac aaagcattga gattggaaga actgcattcc aaagttaatg   7380

atctgaaaga attaactaaa aatctagaaa caccgccaga ccttcagttt atagaagcag   7440

acttaatgca gaaactggag catgccaaag aaataactga agtagcaaaa ggaaccctga   7500

aggatttcac ggctcaaagt acacaagtgg agaagtttat taatgacata acaacatggt   7560

tcacaaaagt ggaagaatcg ttgatgaact gtgcccaaaa tgagacttgt gaagcattga   7620

aaaaagtcaa ggatatacaa aaagaacttc aaagtcaaca aagcaacatc agctctaccc   7680

aagaaaatct caatagcttg tgccgcaagt accactcagc tgagttggag agcctgggcc   7740

gtgcaatgac tggtctgata aagaaacatg aagccgtgag ccagttgtgc tccaaaaccc   7800

aggccagcct gcaggaatct ctggaaaaac acttcagtga gtctatgcag gaattccaag   7860

aatggttttt gggagcaaag gcagcagcaa aagaatcatc agatcgcacc ggtgacagca   7920

aagttctaga agcaaagctc catgatcttc agaacatttt ggactcagtc agtgatgggc   7980

agagcaaact tgatgcagtg actcaagaag gacaaacttt gtatgcacat ttgtctaaac   8040

aaattgtcag tagcattcaa gaacaaatca caaaggccaa tgaagagttt caagcatttc   8100

tgaaacaatg ccttaaagat aagcaggctc ttcaagactg tgcttcagaa cttggaagct   8160

ttgaagatca gcacagaaaa ctgaacttat ggatccatga aatggaagaa aggttcaata   8220

cggaaaactt gggagagagt aaacagcaca ttcctgagaa gaaaaatgaa gttcataaag   8280

ttgaaatgtt tttgggagaa ctgctggctg caagagagtc tcttgataag ctttcccaga   8340

gagggcagct tctgagtgaa gaaggccacg gtgctgggca ggagggccgc ctgtgttccc   8400

agctcctcac aagccaccag aacctactta gaatgaccaa agagaaactc cggagctgcc   8460

aggtggccct tcaggagcac gaagccctgg aggaagcact gcaaagcatg tggttctggg   8520

tgaaggccat tcaggacaga ctggcctgtg cagagagcac tcttgggagc aaagacaccc   8580

tggagaaacg gctgtcacaa atacaggata ttctcctgat gaaaggtgaa ggggaagtta   8640

agttgaatat ggccattggc aagggggaac aggccttgag aagtagcaac aaagaaggtc   8700

agagggtgat tcagactcag ttagagaccc ttaaagaagt gtgggctgac atcatgagct   8760

cctccgtcca cgctcaaagc actttagagt ctgtgattag ccaatggaat gactatgtag   8820

agaggaaaaa ccagttggag cagtggatgg aatcagtgga tcaaaaaata gaacatccct   8880

tacaaccaca gccaggtctg aaagagaagt tcgtcctgct tgaccacctc cagtccatcc   8940

tgtctgaggc agaagatcac acgagagccc ttcaccgtct aattgcgaag tccagggagc   9000

tctacgaaaa gacagaggat gagtctttca aggacacagc tcaagaggag ctgaaaacac   9060

agtttaatga tataatgact gttgccaagg aaaaaatgag gaaagtggaa gagattgtga   9120

aagatcatct aatgtattta gatgcggtcc acgagttcac agattggctc cattcagcaa   9180

aggaagaact tcaccggtgg tcagatatgt ctggagattc atcagccacc cagaaaaagt   9240

tatcaaaaat taaggagctg atagattcca gagagattgg tgcaagccgt ctcagcagag   9300

tggagtcgct ggctcccgaa gtgaaacaga acacaactgc cagtgggtgt gagctcatgc   9360

acacggagat gcaggccctg cgtgccgact ggaagcagtg ggaagacagt gtattccaaa   9420

cgcagagctg tttggagaac ctggtcagcc agatggccct ttcggagcag gaattctcag   9480

gccaagtggc tcaactggag caggccctgg aacagttcag tgcccttctg aaaacctggg   9540

ctcagcagtt aaccctcctg gaaggcaaga acacggatga ggagatagtg gaatgctggc   9600

acaaaggaca agagatactg gatgctttgc aaaaagcaga gcctagaaca gaggatctca   9660

agtctcagct gaatgaactt tgtcgatttt ccagagacct gagtacctac agtggaaaag   9720

tttctggctt gattaaagag tataattgtc tttgtttgca agcatccaag ggctgccaga   9780

ataaagaaca gattttacag caaagatttc gaaaggcctt cagggatttc cagcagtggt   9840

tggttaatgc aaaaatcact accgccaagt gttttgatat acctcaaaat ataagtgaag   9900

tttcaactag tcttcagaaa atacaggagt ttttgtcaga aagtgaaaat ggacagcaca   9960

agctaaacat gatgctgtct aaaggggaac ttctgagtac cctgctgacc aaagagaaag  10020

cgaaagggat ccaggccaaa gttacagctg caaaagaaga ttggaaaaat tttcattcaa  10080

atctccacca aaaagaatct gctctagaga atctaaagat ccaaatgaag gactttgaag  10140

taagtgctga gcctatccag gactggctga gtaaaactga gaagatggtc catgaaagca  10200

gcaatcgcct ctatgatctg ccagcaaaga ggagggagca gcagaagctc cagtctgtcc  10260

ttgaggaaat acactgctac gagcctcagc tcaacaggct gaaagagaaa gctcagcagc  10320

tgtgggaagg acaagctgcc agcaagagct ttaggcacag agtgtcgcag ctgtcttctc  10380

agtatctagc gctaagcaat ttaacaaagg agaaagtgtc aagactggat agaatcgttg  10440

cagaacacaa tcagttctct cttgggatta aagaattaca agactggatg acggatgcga  10500

ttcacatgct ggattcatac tgccacccga catccgacaa aagtgtgctg gacagcagga  10560

cgctcaagct cgaggctcta ttatcagtca aacaggaaaa agagattcag atgaaaatga  10620

tagtgaccag gggagaatct gtccttcaga atacttctcc agaaggcatt cccactattc  10680

agcagcagct gcagagtgtg aaggatatgt gggcatccct tttgtctgca gggattcgtt  10740

gtaaaagcca actcgaagga gctctctcca agtggacaag ttatcaggat ggcgttcgac  10800

agttctccgg ttggatggat agtatggaag ccaacctgaa tgaatcagaa aggcagcatg  10860

cggagctgcg ggataaaaca acgatgctcg gaaaagccaa gttattaaat gaagaagtgc  10920

tgagttacag cagcttgctg gagaccatcg aagtcaaagg ggctggcatg acagaacact  10980

atgtcaccca gctagaactc caggatctac aggaacgata cagagccatc caagagaggg  11040

ccaaggaagc cgtaaccaag tctgaaaaac ttgtccgcct gcaccaagag tatcagagag  11100

acctaaaggc atttgaagtt tggttggggc aagaacaaga aaagctcgac cagtattcag  11160

ttcttgaagg tgatgcccac actcatgaga caacattgcg tgatcttcag gagctacagg  11220

tacactgtgc agaggggcag gccctgttga actcagtgct gcacaccaga gaggatgtga  11280

tcccatcagg tatcccacag gcagaggacc gggctttaga gtctctccgg caagactggc  11340

aggcttacca gcacaggctg tccgagactc gaactcagtt caataacgtg gtgaacaaat  11400

tgaggctaat ggagcaaaag tttcagcaag tagatgaatg gctcaaaaca gcagaggaga  11460

aagttagtcc caggaccaga cgtcagtcta acagggcaac caaggagata caattacatc  11520

agatgaagaa gtggcacgaa gaagtgactg catacagaga tgaagttgag gaagtgggag  11580

ctagagctca ggagatactg gacgagagcc acgtgaacag cagaatgggt tgccaggcca  11640

cccagctgac ttccagatac caggccctgc ttctccaagt gctggaacaa ataaaattcc  11700

tggaggagga gattcagagt ttggaggaat cagaatcatc cctcagttcc tattctgatt  11760

ggtatggctc tactcataaa aacttcaaga atgtggctac caagattgac aaagtagata  11820

cagtaatgat ggggaagaaa ttgaagacgt tggaggtttt gctcaaagac atggagaaag  11880

gtcacagttt gctgaaatca gcccgggaga aaggagagag ggctgttaaa tacttggagg  11940

aaggcgaggc agagaggtta agaaaggaga ttcatgatca catggagcag ttgaaggaac  12000

tgaccagcac tgtccggaaa gaacacatga cgctggaaaa aggtcttcat ttagcaaagg  12060

aattctcaga taaatgcaaa gcactgacac agtggatagc agaataccag gaaattctac  12120

atgttcctga agaacccaaa atggaattat atgagaaaaa agctcagtta tctaaataca  12180

agtcacttca acaaacggtg ctgtcccatg aaccatcagt aaagtcagtg agagagaagg  12240

gtgaagctct tttggaactg gtgcaggacg tcactttaaa ggacaaaata gatcaacttc  12300

aaagtgatta ccaggacctg tgcagcatag gaaaggagca tgtcttcagt ctggaggcga  12360

aagtcaaaga ccatgaagac tacaacagtg agctccaaga ggtcgaaaag tggctgctgc  12420

agatgtctgg cagactggtg gcacctgacc tcctggagac aagcagcctg gagacaatca  12480

cccagcaatt ggcccaccac aaggcaatga tggaagaaat tgctggtttt gaagaccgtt  12540

tgaacaatct tcaaatgaaa ggtgatactt tgattggcca atgtgcagac cacctgcaag  12600

cgaaacttaa acaaaacgtg catgctcatc tgcagggcac aaaggacagc tactcagcga  12660

tctgcagcac agctcagagg atgtaccaga gtttggaaca cgaacttcag aagcacgtca  12720

gccgacaaga caccctgcag cagtgccagg cctggctttc tgcagtccag ccggatttag  12780

agccaagtcc tcaaccacct cttagtaggg cagaagccat taagcaggtc aaacacttca  12840

gagctttgca agagcaggca aggacctacc tagatctcct ttgctccatg tgtgacctgt  12900

caaatgcttc ggtgaaaacc acagcaaaag acattcaaca aacagagcaa acgattgaac  12960

aaaagcttgt ccaggcccag aacttaactc agggctggga agagatcaag cacctgaagt  13020

ctgagctctg gatttacctg caagatgctg atcagcaact gcagaacatg aagaggaggc  13080

actctgagct ggagctgaac attgcacaga acatggtttc acaagttaag gattttgtta  13140

agaaactaca gagcaaacag gcatccgtga acaccataat agaaaaggtg aataagttaa  13200

caaagaagga ggaatcgcct gaacacaagg aaataaatca tttaaatgat cagtggctcg  13260

atttgtgccg tcagtctaac aacctgtgct tgcaaaggga agaggatctt cagagaacaa  13320

gagattacca tgactgtatg aatgttgttg aagtgttcct agaaaaattt actacagaat  13380

gggataactt ggccagatct gatgcagaga gtacagctgt ccacctggaa gctttgaaaa  13440

agttagcatt ggcattgcag gagagaaagt atgctattga agatctgaaa gatcaaaagc  13500

agaaaatgat agagcatctg aatttagatg acaaggagtt agtcaaagaa cagacgagtc  13560

atttagagca acgttggttt cagcttgagg acctcattaa aaggaaaatc caagtgtcag  13620

tcaccaactt ggaggagtta aatgtggtgc agtccagatt tcaggagcta atggagtggg  13680

cagaagagca acaacccaac atcgccgagg cccttaagca gagccctcct ccagatatgg  13740

ctcagaacct tctcatggat cacctggcca tctgcagtga actggaggcc aagcagatgc  13800

tcctgaaatc gcttataaag gacgcagaca gggtcatggc agatcttggt ctcaatgagc  13860

gacaggtcat ccagaaggct ctctctgatg cacaaagcca cgtgaattgt ctcagtgact  13920

tagtgggcca gcgaagaaag tacttaaaca aagccttgtc cgagaaaacc cagtttctca  13980

tggcagtgtt ccaggccacc agccaaattc agcaacatga gcgaaagata atgttccgtg  14040

aacacatctg tctgttacca gatgatgtga gcaaacaagt caaaacatgt aagagtgcac  14100

aagccagcct caagacttac caaaatgaag tcactggact ttgggcccag ggtcgcgaac  14160

taatgaagga agtcacagag caggaaaaga gtgaagtgct ggggaagctt caggaattgc  14220

agagtgtcta tgacagtgtt ttacaaaagt gcagtcaccg gttacaagaa ctagagaaga  14280

atttggtttc taggaagcat tttaaggaag attttgataa agcttgccac tggctaaaac  14340

aagcagatat tgttacattt cctgaaatca acctaatgaa tgagagttct gagcttcata  14400

cacaactggc taaataccaa aacattcttg aacaatctcc agaatatgaa aatcttctac  14460

ttacgctgca gagaactggg cagaccatat taccatcgct gaatgaagtc gatcattcct  14520

acctcagtga aaagctaaat gctttgcctc gacaatttaa tgtaattgtt gccttggcta  14580

aagacaagtt ctataaagtc caggaagcaa ttcttgctcg gaaggaatat gcttccttga  14640

ttgagttgac aacccagtct ctgagtgaac ttgaagccca attcttgagg atgagcaaag  14700

ttcccaccga cctggccgtt gaggaggctc tttctctgca agatggttgc agagccattc  14760

tggacgaggt ggcgggcctt ggggaggcgg tggatgaact gaaccagaaa aaagaaggtt  14820

ttcgcagcac aggtcagcct tggcagccag acaagatgct gcaccttgtc accttatatc  14880

acaggctgaa gcgacaaaca gaacagaggg ttagcttatt agaagacacc accagtgctt  14940

accaagaaca cgagaagatg tgccaacagc tggagagaca actgaagtct gtaaaagagg  15000

agcagtccaa agtgaatgag gaaacgctgc ctgcagagga gaagctcaaa atgtatcact  15060

ccctggcagg aagtctccag gactcaggga ttgtactgaa acgagtaacc atacatcttg  15120

aagatcttgc cccacacctt gaccccttgg cttatgagaa agccaggcat cagatccagt  15180

cctggcaagg ggagttaaaa ctgttgactt ctgccattgg tgagacggtg acagaatgtg  15240

agagccgaat ggtgcagagt atagacttcc agactgagat gagtcgctcc ctggactggc  15300

tgaggagagt gaaggcagag ctcagtgggc cggtgtacct agacctcaac ctgcaggaca  15360

tccaagagga aatcagaaaa atccaaattc atcaggaaga ggtccagtcc agcttgagaa  15420

tcatgaatgc gctgagtcac aaggaaaagg agaagttcac aaaggccaag gagctgattt  15480

ctgcggattt agaacacagc ctcgctgagc tctcagagct ggatggagac atccaggaag  15540

ccttacgcac cagacaggct accttgactg aaatatatag ccagtgtcaa aggtattatc  15600

aggtatttca agcagccaat gactggcttg aggatgccca agaattgtta cagctggcag  15660

gcaatggcct agacgtggag agcgcagagg aaaatctcaa aagccacatg gaatttttca  15720

gtacagagga tcagttccat agtaacctgg aggagctcca cagcctggta gccaccctgg  15780

acccactcat caagccaacc ggcaaagaag acctagaaca gaaagtggct tctctggaac  15840

tcaggagcca gaggatgagc cgggactctg gtgcccaagt ggatctcttg cagagatgca  15900

cagctcaatg gcacgattac cagaaagcaa gggaagaggt tattgaattg atgaatgata  15960

cagaaaagaa attgtctgag ttttctttgt tgaagacttc gtctagtcat gaagcggaag  16020

aaaaattgtc agaacacaag gctttagtgt cagtggttaa ctctttccat gagaaaattg  16080

tggcccttga ggaaaaagct tcacaactgg agaaaaccgg aaatgatgcc agcaaagcca  16140

ccctgagcag gtcaatgacc accgtctggc agcgctggac acgccttcga gctgtggccc  16200

aggaccagga gaagatcctg gaagatgcag tggatgagtg gacgggcttt aacaacaagg  16260

ttaaaaaggc cactgaaatg attgatcagc tgcaagataa gttacctgga agttcagcag  16320

agaaagcatc gaaagcagag ctcttaactc ttcttgaata ccacgacacg ttcgttctgg  16380

agctggagca gcagcagtcg gccttgggca tgctgcggca gcaaaccctg agcatgctcc  16440

aggatggagc cgccccaacc cctggggaag agcctccgct catgcaggaa atcaccgcca  16500

tgcaagatcg gtgcctgaac atgcaggaga aagtgaagac taatggaaag ttggtgaagc  16560

aagagctgaa ggaccgagaa atggtggaga ctcagatcaa ttctgtgaaa tgttgggttc  16620

aggaaacgaa agaatattta gggaatccaa caatagaaat agatgctcaa cttgaagaac  16680

ttcagattct cctaacagaa gccacaaatc accgacagaa cattgaaaaa atggcagaag  16740

aacagaagga gaagtactta ggtctttata ccatattacc ttctgaactc tcccttcagt  16800

tggctgaagt ggcgttagat ctaaagatcc gagatcagat ccaagacaaa ataaaagaag  16860

ttgagcagag caaggccacg agccaggaac tcagccggca aattcagaag ttagctaaag  16920

acctcacaac tattctaact aagctgaaag cgaagacaga taatgtagtt caagctaaaa  16980

ctgaccaaaa ggtgctggga gaggaattag atggctgtaa ttcaaagtta atggaattag  17040

atgcagcagt acagaaattc ttggaacaga atggccaact gggtaagcca ctggccaaga  17100

agataggaaa actgactgaa cttcaccagc agaccattag acaagctgag aatcggctct  17160

ccaagctcaa tcaggcagca tcacatttag aagaatacaa tgaaatgctt gaattaattt  17220

tgaagtggat tgaaaaagct aaagtcttgg ctcatggaac tattgcatgg aattctgcaa  17280

gccagcttcg ggaacaatat attttgcatc agaccctgct agaagaatcc aaagaaattg  17340

acagtgagct ggaagcaatg actgagaaat tacagtacct cactagcgtg tactgtacag  17400

aaaaaatgtc tcagcaagtg gcagaactgg gacgggagac tgaggagttg cgacagatga  17460

tcaaaattcg tttgcagaac ctccaagatg cagctaagga tatgaaaaaa tttgaagcag  17520

agttgaaaaa gttacaagct gccttggagc aagcccaggc aacactgact tctccagaag  17580

ttggacgtct cagtctcaag gagcagctct ctcatcggca gcatttgttg tctgagatgg  17640

agtcactgaa gccgaaggtg caagcagtgc agctctgcca gagtgccctc cggatccccg  17700

aggatgtggt tgccagctta cctctctgtc atgctgctct gcggctgcag gaagaggcca  17760

gccggctgca gcacaccgcc atccagcagt gtaacatcat gcaggcagct gtggtacaat  17820

atgaacaata tgagcaagaa atgaaacatc tccagcaact gatagaagga gctcacagag  17880

agattgagga taaacctgtt gccaccagta acatacagga gctgcaggct cagatttctc  17940

ggcatgagga gctggcgcag aaaattaagg gctaccagga gcagatcgct tctttgaatt  18000

ccaagtgcaa gatgctgacg atgaaagcca agcacgccac catgctgctg acggtgaccg  18060

aggtcgaggg gctggcggaa gggacagagg acctggatgg ggagctcctc cccacgcctt  18120

cggcccaccc ctctgtggtc atgatgactg caggtcgctg tcacactttg ctgtcaccgg  18180

tcactgagga gtctggggag gagggaacca acagtgagat ttcctctcca cctgcctgtc  18240

gctccccttc acctgtggct aatacagatg cttctgttaa ccaggacatt gcatattacc  18300

aagccttgtc tgctgagagg ttgcagacag atgctgcaaa aattcacccc agcacatccg  18360

catcccagga gttctatgaa ccgggattgg agccatccgc tactgccaaa ctgggtgatt  18420

tgcagcgttc ttgggaaacc ttaaagaatg tgatcagtga gaagcagcgc acactctatg  18480

aagctttgga acgccagcag aagtaccagg actccctcca gtccatctct acgaagatgg  18540

aggccattga gctgaaactc agtgagagcc cagagcctgg caggagtcca gaaagccaga  18600

tggctgaaca tcaggcattg atggatgaga ttctcatgct ccaggatgaa atcaatgagc  18660

tccagtcctc tctcgcagag gagctggtat ccgagtcttg tgaggccgac cctgcggagc  18720

agctggcctt gcagtccacg ctcactgtct tagccgagcg aatgtccacc atcaggatga  18780

aagcctcggg gaaacggcag cttttggagg agaagttgaa tgatcagctg gaggaacaaa  18840

ggcaggaaca ggccctgcag aggtatcgct gtgaagccga tgagctggac agctggctct  18900

tgagtaccaa ggccactctg gacactgcgc tgagtccacc caaggagccc atggacatgg  18960

aggcccagct tatggactgc cagaatatgc tggtggaaat agagcagaag gtggtggctt  19020

tatcagaact gtcagtccac aatgagaacc tgctgctgga gggcaaagct cacaccaagg  19080

acgaggccga gcagctggct ggaaagctga gaaggctcaa ggggagcctg ctggagctgc  19140

agagagccct gcatgataag cagctcaaca tgcagggaac agcacaggag aaggaggaga  19200

gcgatgttga cctaacagcc acgcagagcc ccggcgtcca ggaatggctg gcccaagctc  19260

gcaccacatg gacccagcag cggcagagca gtctccagca acaaaaagag ttagaacagg  19320

aattagccga gcagaagagt ctccttcgct cagtagccag tcgtggagag gagattctaa  19380

ttcaacattc ggcggcagag acctctggtg atgctggcga aaaacctgat gtgttatccc  19440

aggagttggg gatggaaggg gagaaatcat ccgctgaaga ccagatgaga atgaaatggg  19500

aaagcctaca tcaagaattt agtaccaagc agaaactact acagaatgtt ctggaacagg  19560

aacaagagca agtgctttat agcaggccaa atcgactctt gtctggtgtg ccactgtaca  19620

aaggggacgt gccaacccaa gataaatctg cagttacatc tttgctggat ggactgaacc  19680

aagccttcga ggaggtttca tcccagagtg gaggggcaaa gaggcagagt atacacttgg  19740

agcagaagtt gtatgatgga gtctcagcca cctctacttg gttggatgac gttgaagaac  19800

gtttatttgt tgccacagca cttttaccag aagaaacaga gacttgtctc ttcaaccaag  19860

agattcttgc caaagacatt aaggaaatgt ctgaagaaat ggataagaac aaaaacttgt  19920

tttcccaagc ttttccagag aatggtgata atcgagatgt tattgaagat actttgggtt  19980

gtcttttggg caggttatcc ttgctagact cagtagtgaa tcaacgatgt catcagatga  20040

aagaaagact tcagcaaata ctaaatttcc agaatgatct gaaagtgctg tttacatcac  20100

tggctgacaa caaatacatc attctgcaaa aactggcaaa tgtgtttgaa cagcccgtag  20160

cagaacaaat agaggcaata caacaggctg aagatggact caaagaattt gatgcaggaa  20220

tcattgaatt aaagaggcgt ggtgacaagc tacaggtcga gcagccgtcc atgcaagaac  20280

tctccaagct ccaggacatg tatgatgagc tgatgatgat cattggctcc cggaggagtg  20340

gtctgaatca gaaccttaca ctcaagagtc agtatgagag ggccctacaa gatctggctg  20400

acctgctaga aactggtcag gagaagatgg caggagacca gaaaatcatc gtgtcttcca  20460

aagaggaaat ccagcaacta cttgacaaac ataaggaata ctttcagggc ctggaatctc  20520

atatgatctt gactgaaaca ctcttcagaa agataatcag ctttgcagtc caaaaggaaa  20580

cccagttcca tacagagctg atggctcagg cttctgctgt actgaaacgg gctcacaaga  20640

ggggtgtgga gctggagtac attctagaga cgtggtccca tctggatgag gaccagcagg  20700

agctcagcag acagctggag gtggtggaaa gcagcatccc aagcgtgggt ctggtggagg  20760

agaacgagga caggcttatt gaccgcataa cactctacca gcatttaaaa tctagcctta  20820

atgaatacca gcccaaatta tatcaagtat tagatgatgg gaaacgactt ctgatatcca  20880

tcagctgctc agatctagaa agccaactaa atcaacttgg agagtgctgg ctaagtaaca  20940

ccaataaaat gtctaaggaa cttcacagac tggaaacaat attgaaacac tggaccagat  21000

atcaaagtga atctgcagat ctaattcact ggttacaatc tgcaaaagac cggctagaat  21060

tttggactca gcaatctgtg acagtcccac aagagctgga aatggtccgt gatcatctaa  21120

atgctttcct ggagttttct aaagaagtgg atgcccaatc ttccctgaaa tcatctgttc  21180

tgagtactgg aaatcagctc cttcgactaa aaaaggtgga cacagccacg ctgcgctctg  21240

agctgtcgcg cattgatagc cagtggactg acctgctaac caatatccca gccgtccagg  21300

agaagctcca ccagctccag atggataaac tgccttcccg ccatgccatt tctgaagtca  21360

tgagttggat ttctctaatg gaaaatgtta ttcagaagga tgaagataat attaaaaatt  21420

ccataggtta caaggcaatt catgaatacc ttcagaaata taagggtttt aagatagaca  21480

ttaactgtaa acagctgaca gtggattttg tgaaccagtc cgtgctacaa atcagcagtc  21540

aggatgtgga aagtaagcgt agtgataaga ctgattttgc tgagcaactt ggagcaatga  21600

ataaaagttg gcaaattctg caaggtctag taactgagaa gatccagctg ttggaaggct  21660

tattggaatc ttggtcagaa tatgaaaata atgtacaatg tctgaaaaca tggtttgaaa  21720

cccaggaaaa gagactaaaa caacagcatc gaattggaga tcaggcttct gttcaaaatg  21780

cactgaaaga ctgtcaggat ctggaagatt tgattaaagc aaaagaaaaa gaagtagaga  21840

aaattgagca gaatggactt gctttgattc agaacaagaa agaagacgtc tctagcattg  21900

tcatgagcac actgcgagag ctcggccaaa cctgggcaaa tttagatcac atggttggac  21960

aattaaagat actgctgaaa tcagtgcttg accaatggag tagtcacaaa gtggcctttg  22020

acaagataaa cagttacctc atggaggcca gatactctct ttcccgattc cgtctgctga  22080

ctggctcctt agaagctgtg caagttcagg tggacaatct tcagaatctc caagatgatc  22140

tggaaaaaca ggaaaggagc ttacagaaat ttggctctat caccaaccaa ttattaaaag  22200

agtgtcaccc acccgtgaca gaaactctta ccaatacact gaaagaagtc aacatgagat  22260

ggaataactt gctggaagag attgctgagc agctacagtc cagcaaggcc ctacttcagc  22320

tttggcaaag atacaaggac tactccaaac agtgtgcttc gacagttcag cagcaggagg  22380

atcgaaccaa tgagctgttg aaggcagcca caaacaagga cattgccgat gatgaggttg  22440

ccacatggat tcaagattgc aacgacctcc tcaaaggact gggcacagtt aaagattccc  22500

tcttttttct ccatgagctg ggagagcaac tgaagcaaca agtggatgct tccgcagcat  22560

cagctattca atcggatcaa ctctctttga gtcaacactt gtgtgccctg gagcaagctc  22620

tctgcaaaca gcagacttca ttacaggctg gagttcttga ttatgaaacc tttgccaaga  22680

gtttagaagc tttggaggcc tggatagtgg aagctgaaga aatactacaa gggcaggacc  22740

ctagccactc atctgacctc tccacaatcc aggaaaggat ggaagaactt aagggacaga  22800

tgttaaaatt cagcagcatg gctccagatt tagaccgtct aaatgagctt ggatataggt  22860

tacccttgaa tgataaggaa atcaaaagaa tgcagaatct gaaccgccat tggtctctga  22920

tctcctctca gactacagaa agattcagca agttgcagtc atttttgcta caacatcaga  22980

ctttcttgga aaaatgtgaa acatggatgg aattcctagt tcagacagaa caaaagttag  23040

cagtagagat ttcaggaaat tatcagcacc ttttggaaca gcagagagca cacgagttgt  23100

ttcaagccga gatgttcagt cgtcagcaga ttttgcactc aatcattatt gatgggcaac  23160

gtcttctaga acaaggtcaa gttgatgaca gggatgaatt caacctgaaa ttgacactcc  23220

tcagtaatca atggcaggga gtgattcgca gggcccagca gaggcggggg atcattgaca  23280

gccagattcg ccagtggcag cgctataggg agatggcaga aaagcttcgt aaatggttgg  23340

ttgaagtgtc ctacctcccc atgagtggtc tcggaagtgt tcctatacca ctgcaacaag  23400

caaggaccct ctttgatgaa gtgcagttca aagaaaaagt gtttctgcgg caacaaggca  23460

gctacatcct gactgtggag gctggcaagc aactccttct ctcggcggac agtggcgctg  23520

aggccgcctt gcaggccgaa ctcgctgaaa tccaagagaa atggaaatca gccagcatgc  23580

ggctggaaga acagaagaaa aaactagcct tcttgttgaa agactgggaa aaatgtgaga  23640

aaggaatagc agattccctg gagaaactac gaactttcaa aaagaagctt tcgcagtctc  23700

tcccggatca ccatgaagag ctccatgcag aacaaatgcg ttgcaaggaa ttagaaaatg  23760

cagttgggag ctggacagat gacttgaccc agttgagcct gctgaaggac accctctctg  23820

cctatatcag tgctgatgat atctccattc ttaatgaacg cgtagagctt ctgcaaaggc  23880

agtgggaaga actatgccac cagctctcct taaggcggca gcaaataggt gaaagattga  23940

atgaatgggc agtcttcagt gaaaagaaca aggaactctg tgagtggttg actcaaatgg  24000

aaagcaaagt ttctcagaat ggagacattc tcattgaaga aatgatagag aagctcaaga  24060

aggattatca agaggaaatt gctattgctc aagagaacaa aatacagctc caacaaatgg  24120

gagaacgact tgctaaagcc agccatgaaa gcaaagcatc tgagattgaa tacaagctgg  24180

gaaaggtcaa cgaccggtgg cagcatctcc tggacctcat tgcagccagg gtgaagaagc  24240

tgaaggagac cctggtagcc gtgcagcagc ttgataagaa catgagcagc ctgaggacct  24300

ggctcgctca catcgagtca gagctggcca agccaatagt ctacgattcc tgtaactcgg  24360

aagaaataca gagaaagctt aatgagcagc aggagcttca gagagacata gagaagcaca  24420

gtacaggtgt tgcatctgtc ctcaacctgt gtgaagtcct gctgcacgac tgtgacgcct  24480

gtgccactga tgccgagtgt gactctatac agcaggctac gagaaacctg gaccggcggt  24540

ggagaaacat ttgtgctatg tccatggaaa ggaggctgaa aatcgaagag acgtggcgat  24600

tgtggcagaa atttctggat gactattcac gttttgaaga ttggctgaag tcttcagaaa  24660

ggacagctgc ttttcccagc tcttctgggg tgatctatac agttgccaag gaagaactaa  24720

agaaatttga ggctttccag cgacaggtcc acgagtgcct gacgcagctg gaactgatca  24780

acaagcagta ccgccgcctg gccagggaga accgcactga ttcagcatgt agcctcaaac  24840

agatggttca cgaaggcaac cagagatggg acaacctgca aaagcgtgtc acctccatct  24900

tgcgcagact caagcatttt attggccagc gtgaggagtt tgagactgcg cgggacagca  24960

ttctggtctg gctcacagag atggatctgc agctcactaa tattgaacat ttttctgagt  25020

gtgatgttca agctaaaata aagcaactca aggccttcca gcaggaaatt tcactgaacc  25080

acaataagat tgagcagata attgcccaag gagaacagct gatagaaaag agtgagccct  25140

tggatgcagc gatcatcgag gaggaactag atgagctccg acggtactgc caggaggtct  25200

tcgggcgtgt ggaaagatac cataagaaac tgatccgcct gcctctccca gacgatgagc  25260

acgacctctc agacagggag ctggagctgg aagactctgc agctctgtcg gacctgcact  25320

ggcacgaccg ctctgcagac agcctgcttt ctccacagcc ttcctccaat ctctccctct  25380

cgctcgctca gcccctccgg agcgagcggt caggacgaga caccccggct agtgtggact  25440

ccatccccct ggagtgggat cacgactatg acctcagtcg ggacctggag tctgcaatgt  25500

ccagagctct gccctctgag gatgaagaag gtcaggatga caaagatttc tacctccggg  25560

gagctgttgg cttatcaggg gaccacagtg ccctagagtc acagatccga caactgggca  25620

aagccctgga tgatagccgt tttcagatac agcaaaccga aaatatcatt cgcagcaaaa  25680

ctcccacggg gccggagcta gacaccagct acaaaggcta catgaaactg ctgggcgaat  25740

gcagtagcag tatagactcc gtgaagagac tggagcacaa actgaaggag gaagaggaga  25800

gccttcctgg ctttgttaac ctgcatagta ccgaaaccca aacggctggt gtgattgacc  25860

gatgggagct tctccaggcc caggcattga gcaaggagtt gaggatgaag cagaacctcc  25920

agaagtggca gcagtttaac tcagacttga acagcatctg ggcctggctg ggggacacgg  25980

aggaggagtt ggaacagctc cagcgtctgg aactcagcac tgacatccag accatcgagc  26040

tccagatcaa aaagctcaag gagctccaga aagctgtgga ccaccgcaaa gccatcatcc  26100

tctccatcaa tctctgcagc cctgagttca cccaggctga cagcaaggag agccgggacc  26160

tgcaggatcg cttgtcgcag atgaatgggc gctgggaccg agtgtgctct ctgctggagg  26220

agtggcgggg cctgctgcag gatgccctga tgcagtgcca gggtttccat gaaatgagcc  26280

atggtttgct tcttatgctg gagaacattg acagaaggaa aaatgaaatt gtccctattg  26340

attctaacct tgatgcagag atacttcagg accatcacaa acagcttatg caaataaagc  26400

atgagctgtt ggaatcccaa ctcagagtag cctctttgca agacatgtct tgccaactac  26460

tggtgaatgc tgaaggaaca gactgtttag aagccaaaga aaaagtccat gttattggaa  26520

atcggctcaa acttctcttg aaggaggtca gtcgtcatat caaggaactg gagaagttat  26580

tagacgtgtc aagtagtcag caggatttgt cttcctggtc ttctgctgat gaactggaca  26640

cctcagggtc tgtgagtccc acatcaggaa ggagcacccc aaacagacag aaaacgccac  26700

gaggcaagtg tagtctctca cagcctggac cctctgtcag cagtccacat agcaggtcca  26760

caaaaggtgg ctccgattcc tccctttctg agccagggcc aggtcggtcc ggccgcggct  26820

tcctgttcag agtcctccga gcagctcttc cccttcagct tctcctgctc ctcctcatcg  26880

ggcttgcctg ccttgtacca atgtcagagg aagactacag ctgtgccctc tccaacaact  26940

ttgcccggtc attccacccc atgctcagat acacgaatgg ccctcctcca ctctgaacta  27000

agcagatgcc atctgcagaa gtgctggtag cataaggagg atcgggtcat aagcaatccc  27060

aaactaccaa caagaggacc ttgatcttgg cgaaagccct cggtgtggca gctttagccc  27120

tcctccagat cacatgtgtg caaattatgg cttcagaggt ggaagataaa cagtgacggg  27180

ggaacaaaca gacaacaaga aggtttggaa gaaatctggt ttgagactct gaaccttagc  27240

actaaggaga ttgagtaagg acctccaaag ttccccggac tcatgaattc tgggcccttg  27300

gcccattctg tgcacagcca aggacttcag tagaccatct gggcagcttt cccatggtgc  27360

tgctccaacc atcagataaa tgaccctccc aagcaccatg tcagtgtcgt acaatctacc  27420

aaccaaccag tgctgaagag attttagaac cttgtaacat acaattttta agagcttata  27480

tggcagcttc ctttttacct tgttttcctt tggggcatga tgttttaacc tttgctttag  27540

aagcacaagc tgtaaatcta aaaggcactt ttttttagag gtataaagaa aaactagatg  27600

taataaataa gatcatggaa ggctttatgt gaaaaaagtt gaatgttata gtaaaaaaaa  27660

aaagatattt atgtatgtac agtttgctaa agccaagttt tgtttgtatt gatttctttg  27720

catttattat agatattata aaatagtt                                     27748


<210>  3419
<211>  8797
<212>  PRT
<213>  Homo sapiens

<400>  3419

Met Ala Thr Ser Arg Gly Ala Ser Arg Cys Pro Arg Asp Ile Ala Asn 
1               5                   10                  15


Val Met Gln Arg Leu Gln Asp Glu Gln Glu Ile Val Gln Lys Arg Thr 
            20                  25                  30


Phe Thr Lys Trp Ile Asn Ser His Leu Ala Lys Arg Lys Pro Pro Met 
        35                  40                  45


Val Val Asp Asp Leu Phe Glu Asp Met Lys Asp Gly Val Lys Leu Leu 
    50                  55                  60


Ala Leu Leu Glu Val Leu Ser Gly Gln Lys Leu Pro Cys Glu Gln Gly 
65                  70                  75                  80


Arg Arg Met Lys Arg Ile His Ala Val Ala Asn Ile Gly Thr Ala Leu 
                85                  90                  95


Lys Phe Leu Glu Gly Arg Lys Ile Lys Leu Val Asn Ile Asn Ser Thr 
            100                 105                 110


Asp Ile Ala Asp Gly Arg Pro Ser Ile Val Leu Gly Leu Met Trp Thr 
        115                 120                 125


Ile Ile Leu Tyr Phe Gln Ile Glu Glu Leu Thr Ser Asn Leu Pro Gln 
    130                 135                 140


Leu Gln Ser Leu Ser Ser Ser Ala Ser Ser Val Asp Ser Ile Val Ser 
145                 150                 155                 160


Ser Glu Thr Pro Ser Pro Pro Ser Lys Arg Lys Val Thr Thr Lys Ile 
                165                 170                 175


Gln Gly Asn Ala Lys Lys Ala Leu Leu Lys Trp Val Gln Tyr Thr Ala 
            180                 185                 190


Gly Lys Gln Thr Gly Ile Glu Val Lys Asp Phe Gly Lys Ser Trp Arg 
        195                 200                 205


Ser Gly Val Ala Phe His Ser Val Ile His Ala Ile Arg Pro Glu Leu 
    210                 215                 220


Val Asp Leu Glu Thr Val Lys Gly Arg Ser Asn Arg Glu Asn Leu Glu 
225                 230                 235                 240


Asp Ala Phe Thr Ile Ala Glu Thr Glu Leu Gly Ile Pro Arg Leu Leu 
                245                 250                 255


Asp Pro Glu Asp Val Asp Val Asp Lys Pro Asp Glu Lys Ser Ile Met 
            260                 265                 270


Thr Tyr Val Ala Gln Phe Leu Lys His Tyr Pro Asp Ile His Asn Ala 
        275                 280                 285


Ser Thr Asp Gly Gln Glu Asp Asp Glu Ile Leu Pro Gly Phe Pro Ser 
    290                 295                 300


Phe Ala Asn Ser Val Gln Asn Phe Lys Arg Glu Asp Arg Val Ile Phe 
305                 310                 315                 320


Lys Glu Met Lys Val Trp Ile Glu Gln Phe Glu Arg Asp Leu Thr Arg 
                325                 330                 335


Ala Gln Met Val Glu Ser Asn Leu Gln Asp Lys Tyr Gln Ser Phe Lys 
            340                 345                 350


His Phe Arg Val Gln Tyr Glu Met Lys Arg Lys Gln Ile Glu His Leu 
        355                 360                 365


Ile Gln Pro Leu His Arg Asp Gly Lys Leu Ser Leu Asp Gln Ala Leu 
    370                 375                 380


Val Lys Gln Ser Trp Asp Arg Val Thr Ser Arg Leu Phe Asp Trp His 
385                 390                 395                 400


Ile Gln Leu Asp Lys Ser Leu Pro Ala Pro Leu Gly Thr Ile Gly Ala 
                405                 410                 415


Trp Leu Tyr Arg Ala Glu Val Ala Leu Arg Glu Glu Ile Thr Val Gln 
            420                 425                 430


Gln Val His Glu Glu Thr Ala Asn Thr Ile Gln Arg Lys Leu Glu Gln 
        435                 440                 445


His Lys Asp Leu Leu Gln Asn Thr Asp Ala His Lys Arg Ala Phe His 
    450                 455                 460


Glu Ile Tyr Arg Thr Arg Ser Val Asn Gly Ile Pro Val Pro Pro Asp 
465                 470                 475                 480


Gln Leu Glu Asp Met Ala Glu Arg Phe His Phe Val Ser Ser Thr Ser 
                485                 490                 495


Glu Leu His Leu Met Lys Met Glu Phe Leu Glu Leu Lys Tyr Arg Leu 
            500                 505                 510


Leu Ser Leu Leu Val Leu Ala Glu Ser Lys Leu Lys Ser Trp Ile Ile 
        515                 520                 525


Lys Tyr Gly Arg Arg Glu Ser Val Glu Gln Leu Leu Gln Asn Tyr Val 
    530                 535                 540


Ser Phe Ile Glu Asn Ser Lys Phe Phe Glu Gln Tyr Glu Val Thr Tyr 
545                 550                 555                 560


Gln Ile Leu Lys Gln Thr Ala Glu Met Tyr Val Lys Ala Asp Gly Ser 
                565                 570                 575


Val Glu Glu Ala Glu Asn Val Met Lys Phe Met Asn Glu Thr Thr Ala 
            580                 585                 590


Gln Trp Arg Asn Leu Ser Val Glu Val Arg Ser Val Arg Ser Met Leu 
        595                 600                 605


Glu Glu Val Ile Ser Asn Trp Asp Arg Tyr Gly Asn Thr Val Ala Ser 
    610                 615                 620


Leu Gln Ala Trp Leu Glu Asp Ala Glu Lys Met Leu Asn Gln Ser Glu 
625                 630                 635                 640


Asn Ala Lys Lys Asp Phe Phe Arg Asn Leu Pro His Trp Ile Gln Gln 
                645                 650                 655


His Thr Ala Met Asn Asp Ala Gly Asn Phe Leu Ile Glu Thr Cys Asp 
            660                 665                 670


Glu Met Val Ser Arg Asp Leu Lys Gln Gln Leu Leu Leu Leu Asn Gly 
        675                 680                 685


Arg Trp Arg Glu Leu Phe Met Glu Val Lys Gln Tyr Ala Gln Ala Asp 
    690                 695                 700


Glu Met Asp Arg Met Lys Lys Glu Tyr Thr Asp Cys Val Val Thr Leu 
705                 710                 715                 720


Ser Ala Phe Ala Thr Glu Ala His Lys Lys Leu Ser Glu Pro Leu Glu 
                725                 730                 735


Val Ser Phe Met Asn Val Lys Leu Leu Ile Gln Asp Leu Glu Asp Ile 
            740                 745                 750


Glu Gln Arg Val Pro Val Met Asp Ala Gln Tyr Lys Ile Ile Thr Lys 
        755                 760                 765


Thr Ala His Leu Ile Thr Lys Glu Ser Pro Gln Glu Glu Gly Lys Glu 
    770                 775                 780


Met Phe Ala Thr Met Ser Lys Leu Lys Glu Gln Leu Thr Lys Val Lys 
785                 790                 795                 800


Glu Cys Tyr Ser Pro Leu Leu Tyr Glu Ser Gln Gln Leu Leu Ile Pro 
                805                 810                 815


Leu Glu Glu Leu Glu Lys Gln Met Thr Ser Phe Tyr Asp Ser Leu Gly 
            820                 825                 830


Lys Ile Asn Glu Ile Ile Thr Val Leu Glu Arg Glu Ala Gln Ser Ser 
        835                 840                 845


Ala Leu Phe Lys Gln Lys His Gln Glu Leu Leu Ala Cys Gln Glu Asn 
    850                 855                 860


Cys Lys Lys Thr Leu Thr Leu Ile Glu Lys Gly Ser Gln Ser Val Gln 
865                 870                 875                 880


Lys Phe Val Thr Leu Ser Asn Val Leu Lys His Phe Asp Gln Thr Arg 
                885                 890                 895


Leu Gln Arg Gln Ile Ala Asp Ile His Val Ala Phe Gln Ser Met Val 
            900                 905                 910


Lys Lys Thr Gly Asp Trp Lys Lys His Val Glu Thr Asn Ser Arg Leu 
        915                 920                 925


Met Lys Lys Phe Glu Glu Ser Arg Ala Glu Leu Glu Lys Val Leu Arg 
    930                 935                 940


Ile Ala Gln Glu Gly Leu Glu Glu Lys Gly Asp Pro Glu Glu Leu Leu 
945                 950                 955                 960


Arg Arg His Thr Glu Phe Phe Ser Gln Leu Asp Gln Arg Val Leu Asn 
                965                 970                 975


Ala Phe Leu Lys Ala Cys Asp Glu Leu Thr Asp Ile Leu Pro Glu Gln 
            980                 985                 990


Glu Gln Gln Gly Leu Gln Glu Ala Val Arg Lys Leu His Lys Gln Trp 
        995                 1000                1005


Lys Asp Leu Gln Gly Glu Ala Pro Tyr His Leu Leu His Leu Lys Ile 
    1010                1015                1020


Asp Val Glu Lys Asn Arg Phe Leu Ala Ser Val Glu Glu Cys Arg Thr 
1025                1030                1035                1040


Glu Leu Asp Arg Glu Thr Lys Leu Met Pro Gln Glu Gly Ser Glu Lys 
                1045                1050                1055


Ile Ile Lys Glu His Arg Val Phe Phe Ser Asp Lys Gly Pro His His 
            1060                1065                1070


Leu Cys Glu Lys Arg Leu Gln Leu Ile Glu Glu Leu Cys Val Lys Leu 
        1075                1080                1085


Pro Val Arg Asp Pro Val Arg Asp Thr Pro Gly Thr Cys His Val Thr 
    1090                1095                1100


Leu Lys Glu Leu Arg Ala Ala Ile Asp Ser Thr Tyr Arg Lys Leu Met 
1105                1110                1115                1120


Glu Asp Pro Asp Lys Trp Lys Asp Tyr Thr Ser Arg Phe Ser Glu Phe 
                1125                1130                1135


Ser Ser Trp Ile Ser Thr Asn Glu Thr Gln Leu Lys Gly Ile Lys Gly 
            1140                1145                1150


Glu Ala Ile Asp Thr Ala Asn His Gly Glu Val Lys Arg Ala Val Glu 
        1155                1160                1165


Glu Ile Arg Asn Gly Val Thr Lys Arg Gly Glu Thr Leu Ser Trp Leu 
    1170                1175                1180


Lys Ser Arg Leu Lys Val Leu Thr Glu Val Ser Ser Glu Asn Glu Ala 
1185                1190                1195                1200


Gln Lys Gln Gly Asp Glu Leu Ala Lys Leu Ser Ser Ser Phe Lys Ala 
                1205                1210                1215


Leu Val Thr Leu Leu Ser Glu Val Glu Lys Met Leu Ser Asn Phe Gly 
            1220                1225                1230


Asp Cys Val Gln Tyr Lys Glu Ile Val Lys Asn Ser Leu Glu Glu Leu 
        1235                1240                1245


Ile Ser Gly Ser Lys Glu Val Gln Glu Gln Ala Glu Lys Ile Leu Asp 
    1250                1255                1260


Thr Glu Asn Leu Phe Glu Ala Gln Gln Leu Leu Leu His His Gln Gln 
1265                1270                1275                1280


Lys Thr Lys Arg Ile Ser Ala Lys Lys Arg Asp Val Gln Gln Gln Ile 
                1285                1290                1295


Ala Gln Ala Gln Gln Gly Glu Gly Gly Leu Pro Asp Arg Gly His Glu 
            1300                1305                1310


Glu Leu Arg Lys Leu Glu Ser Thr Leu Asp Gly Leu Glu Arg Ser Arg 
        1315                1320                1325


Glu Arg Gln Glu Arg Arg Ile Gln Val Thr Leu Arg Lys Trp Glu Arg 
    1330                1335                1340


Phe Glu Thr Asn Lys Glu Thr Val Val Arg Tyr Leu Phe Gln Thr Gly 
1345                1350                1355                1360


Ser Ser His Glu Arg Phe Leu Ser Phe Ser Ser Leu Glu Ser Leu Ser 
                1365                1370                1375


Ser Glu Leu Glu Gln Thr Lys Glu Phe Ser Lys Arg Thr Glu Ser Ile 
            1380                1385                1390


Ala Val Gln Ala Glu Asn Leu Val Lys Glu Ala Ser Glu Ile Pro Leu 
        1395                1400                1405


Gly Pro Gln Asn Lys Gln Leu Leu Gln Gln Gln Ala Lys Ser Ile Lys 
    1410                1415                1420


Glu Gln Val Lys Lys Leu Glu Asp Thr Leu Glu Glu Asp Ile Lys Thr 
1425                1430                1435                1440


Met Glu Met Val Lys Thr Lys Trp Asp His Phe Gly Ser Asn Phe Glu 
                1445                1450                1455


Thr Leu Ser Val Trp Ile Thr Glu Lys Glu Lys Glu Leu Asn Ala Leu 
            1460                1465                1470


Glu Thr Ser Ser Ser Ala Met Asp Met Gln Ile Ser Gln Ile Lys Val 
        1475                1480                1485


Thr Ile Gln Glu Ile Glu Ser Lys Leu Ser Ser Ile Val Gly Leu Glu 
    1490                1495                1500


Glu Glu Ala Gln Ser Phe Ala Gln Phe Val Thr Thr Gly Glu Ser Ala 
1505                1510                1515                1520


Arg Ile Lys Ala Lys Leu Thr Gln Ile Arg Arg Tyr Gly Glu Glu Leu 
                1525                1530                1535


Arg Glu His Ala Gln Cys Leu Glu Gly Thr Ile Leu Gly His Leu Ser 
            1540                1545                1550


Gln Gln Gln Lys Phe Glu Glu Asn Leu Arg Lys Ile Gln Gln Ser Val 
        1555                1560                1565


Ser Glu Phe Glu Asp Lys Leu Ala Val Pro Ile Lys Ile Cys Ser Ser 
    1570                1575                1580


Ala Thr Glu Thr Tyr Lys Val Leu Gln Glu His Met Asp Leu Cys Gln 
1585                1590                1595                1600


Ala Leu Glu Ser Leu Ser Ser Ala Ile Thr Ala Phe Ser Ala Ser Ala 
                1605                1610                1615


Arg Lys Val Val Asn Arg Asp Ser Cys Val Gln Glu Ala Ala Ala Leu 
            1620                1625                1630


Gln Gln Gln Tyr Glu Asp Ile Leu Arg Arg Ala Lys Glu Arg Gln Thr 
        1635                1640                1645


Ala Leu Glu Asn Leu Leu Ala His Trp Gln Arg Leu Glu Lys Glu Leu 
    1650                1655                1660


Ser Ser Phe Leu Thr Trp Leu Glu Arg Gly Glu Ala Lys Ala Ser Ser 
1665                1670                1675                1680


Pro Glu Met Asp Ile Ser Ala Asp Arg Val Lys Val Glu Gly Glu Leu 
                1685                1690                1695


Gln Leu Ile Gln Ala Leu Gln Asn Glu Val Val Ser Gln Ala Ser Phe 
            1700                1705                1710


Tyr Ser Lys Leu Leu Gln Leu Lys Glu Ser Leu Phe Ser Val Ala Ser 
        1715                1720                1725


Lys Asp Asp Val Lys Met Met Lys Leu His Leu Glu Gln Leu Asp Glu 
    1730                1735                1740


Arg Trp Arg Asp Leu Pro Gln Ile Ile Asn Lys Arg Ile Asn Phe Leu 
1745                1750                1755                1760


Gln Ser Val Val Ala Glu His Gln Gln Phe Asp Glu Leu Leu Leu Ser 
                1765                1770                1775


Phe Ser Val Trp Ile Lys Leu Phe Leu Ser Glu Leu Gln Thr Thr Ser 
            1780                1785                1790


Glu Ile Ser Ile Met Asp His Gln Val Ala Leu Thr Arg His Lys Asp 
        1795                1800                1805


His Ala Ala Glu Val Glu Ser Lys Lys Gly Glu Leu Gln Ser Leu Gln 
    1810                1815                1820


Gly His Leu Ala Lys Leu Gly Ser Leu Gly Arg Ala Glu Asp Leu His 
1825                1830                1835                1840


Leu Leu Gln Gly Lys Ala Glu Asp Cys Phe Gln Leu Phe Glu Glu Ala 
                1845                1850                1855


Ser Gln Val Val Glu Arg Arg Gln Leu Ala Leu Ser His Leu Ala Glu 
            1860                1865                1870


Phe Leu Gln Ser His Ala Ser Leu Ser Gly Ile Leu Arg Gln Leu Arg 
        1875                1880                1885


Gln Thr Val Glu Ala Thr Asn Ser Met Asn Lys Asn Glu Ser Asp Leu 
    1890                1895                1900


Ile Glu Lys Asp Leu Asn Asp Ala Leu Gln Asn Ala Lys Ala Leu Glu 
1905                1910                1915                1920


Ser Ala Ala Val Ser Leu Asp Gly Ile Leu Ser Lys Ala Gln Tyr His 
                1925                1930                1935


Leu Lys Ile Gly Ser Ser Glu Gln Arg Thr Ser Cys Arg Ala Thr Ala 
            1940                1945                1950


Asp Gln Leu Cys Gly Glu Val Glu Arg Ile Gln Asn Leu Leu Gly Thr 
        1955                1960                1965


Lys Gln Ser Glu Ala Asp Ala Leu Ala Val Leu Lys Lys Ala Phe Gln 
    1970                1975                1980


Asp Gln Lys Glu Glu Leu Leu Lys Ser Ile Glu Asp Ile Glu Glu Arg 
1985                1990                1995                2000


Thr Asp Lys Glu Arg Leu Lys Glu Pro Thr Arg Gln Ala Leu Gln Gln 
                2005                2010                2015


Arg Leu Arg Val Phe Asn Gln Leu Glu Asp Glu Leu Asn Ser His Glu 
            2020                2025                2030


His Glu Leu Cys Trp Leu Lys Asp Lys Ala Lys Gln Ile Ala Gln Lys 
        2035                2040                2045


Asp Val Ala Phe Ala Pro Glu Val Asp Arg Glu Ile Asn Arg Leu Glu 
    2050                2055                2060


Val Thr Trp Asp Asp Thr Lys Arg Leu Ile His Glu Asn Gln Gly Gln 
2065                2070                2075                2080


Cys Cys Gly Leu Ile Asp Leu Met Arg Glu Tyr Gln Asn Leu Lys Ser 
                2085                2090                2095


Ala Val Ser Lys Val Leu Glu Asn Ala Ser Ser Val Ile Val Thr Arg 
            2100                2105                2110


Thr Thr Ile Lys Asp Gln Glu Asp Leu Lys Trp Ala Phe Ser Lys His 
        2115                2120                2125


Glu Thr Ala Lys Asn Lys Met Asn Tyr Lys Gln Lys Asp Leu Asp Asn 
    2130                2135                2140


Phe Thr Ser Lys Gly Lys His Leu Leu Ser Glu Leu Lys Lys Ile His 
2145                2150                2155                2160


Ser Ser Asp Phe Ser Leu Val Lys Thr Asp Met Glu Ser Thr Val Asp 
                2165                2170                2175


Lys Trp Leu Asp Val Ser Glu Lys Leu Glu Glu Asn Met Asp Arg Leu 
            2180                2185                2190


Arg Val Ser Leu Ser Ile Trp Asp Asp Val Leu Ser Thr Arg Asp Glu 
        2195                2200                2205


Ile Glu Gly Trp Ser Asn Asn Cys Val Pro Gln Met Ala Glu Asn Ile 
    2210                2215                2220


Ser Asn Leu Asp Asn His Leu Arg Ala Glu Glu Leu Leu Lys Glu Phe 
2225                2230                2235                2240


Glu Ser Glu Val Lys Asn Lys Ala Leu Arg Leu Glu Glu Leu His Ser 
                2245                2250                2255


Lys Val Asn Asp Leu Lys Glu Leu Thr Lys Asn Leu Glu Thr Pro Pro 
            2260                2265                2270


Asp Leu Gln Phe Ile Glu Ala Asp Leu Met Gln Lys Leu Glu His Ala 
        2275                2280                2285


Lys Glu Ile Thr Glu Val Ala Lys Gly Thr Leu Lys Asp Phe Thr Ala 
    2290                2295                2300


Gln Ser Thr Gln Val Glu Lys Phe Ile Asn Asp Ile Thr Thr Trp Phe 
2305                2310                2315                2320


Thr Lys Val Glu Glu Ser Leu Met Asn Cys Ala Gln Asn Glu Thr Cys 
                2325                2330                2335


Glu Ala Leu Lys Lys Val Lys Asp Ile Gln Lys Glu Leu Gln Ser Gln 
            2340                2345                2350


Gln Ser Asn Ile Ser Ser Thr Gln Glu Asn Leu Asn Ser Leu Cys Arg 
        2355                2360                2365


Lys Tyr His Ser Ala Glu Leu Glu Ser Leu Gly Arg Ala Met Thr Gly 
    2370                2375                2380


Leu Ile Lys Lys His Glu Ala Val Ser Gln Leu Cys Ser Lys Thr Gln 
2385                2390                2395                2400


Ala Ser Leu Gln Glu Ser Leu Glu Lys His Phe Ser Glu Ser Met Gln 
                2405                2410                2415


Glu Phe Gln Glu Trp Phe Leu Gly Ala Lys Ala Ala Ala Lys Glu Ser 
            2420                2425                2430


Ser Asp Arg Thr Gly Asp Ser Lys Val Leu Glu Ala Lys Leu His Asp 
        2435                2440                2445


Leu Gln Asn Ile Leu Asp Ser Val Ser Asp Gly Gln Ser Lys Leu Asp 
    2450                2455                2460


Ala Val Thr Gln Glu Gly Gln Thr Leu Tyr Ala His Leu Ser Lys Gln 
2465                2470                2475                2480


Ile Val Ser Ser Ile Gln Glu Gln Ile Thr Lys Ala Asn Glu Glu Phe 
                2485                2490                2495


Gln Ala Phe Leu Lys Gln Cys Leu Lys Asp Lys Gln Ala Leu Gln Asp 
            2500                2505                2510


Cys Ala Ser Glu Leu Gly Ser Phe Glu Asp Gln His Arg Lys Leu Asn 
        2515                2520                2525


Leu Trp Ile His Glu Met Glu Glu Arg Phe Asn Thr Glu Asn Leu Gly 
    2530                2535                2540


Glu Ser Lys Gln His Ile Pro Glu Lys Lys Asn Glu Val His Lys Val 
2545                2550                2555                2560


Glu Met Phe Leu Gly Glu Leu Leu Ala Ala Arg Glu Ser Leu Asp Lys 
                2565                2570                2575


Leu Ser Gln Arg Gly Gln Leu Leu Ser Glu Glu Gly His Gly Ala Gly 
            2580                2585                2590


Gln Glu Gly Arg Leu Cys Ser Gln Leu Leu Thr Ser His Gln Asn Leu 
        2595                2600                2605


Leu Arg Met Thr Lys Glu Lys Leu Arg Ser Cys Gln Val Ala Leu Gln 
    2610                2615                2620


Glu His Glu Ala Leu Glu Glu Ala Leu Gln Ser Met Trp Phe Trp Val 
2625                2630                2635                2640


Lys Ala Ile Gln Asp Arg Leu Ala Cys Ala Glu Ser Thr Leu Gly Ser 
                2645                2650                2655


Lys Asp Thr Leu Glu Lys Arg Leu Ser Gln Ile Gln Asp Ile Leu Leu 
            2660                2665                2670


Met Lys Gly Glu Gly Glu Val Lys Leu Asn Met Ala Ile Gly Lys Gly 
        2675                2680                2685


Glu Gln Ala Leu Arg Ser Ser Asn Lys Glu Gly Gln Arg Val Ile Gln 
    2690                2695                2700


Thr Gln Leu Glu Thr Leu Lys Glu Val Trp Ala Asp Ile Met Ser Ser 
2705                2710                2715                2720


Ser Val His Ala Gln Ser Thr Leu Glu Ser Val Ile Ser Gln Trp Asn 
                2725                2730                2735


Asp Tyr Val Glu Arg Lys Asn Gln Leu Glu Gln Trp Met Glu Ser Val 
            2740                2745                2750


Asp Gln Lys Ile Glu His Pro Leu Gln Pro Gln Pro Gly Leu Lys Glu 
        2755                2760                2765


Lys Phe Val Leu Leu Asp His Leu Gln Ser Ile Leu Ser Glu Ala Glu 
    2770                2775                2780


Asp His Thr Arg Ala Leu His Arg Leu Ile Ala Lys Ser Arg Glu Leu 
2785                2790                2795                2800


Tyr Glu Lys Thr Glu Asp Glu Ser Phe Lys Asp Thr Ala Gln Glu Glu 
                2805                2810                2815


Leu Lys Thr Gln Phe Asn Asp Ile Met Thr Val Ala Lys Glu Lys Met 
            2820                2825                2830


Arg Lys Val Glu Glu Ile Val Lys Asp His Leu Met Tyr Leu Asp Ala 
        2835                2840                2845


Val His Glu Phe Thr Asp Trp Leu His Ser Ala Lys Glu Glu Leu His 
    2850                2855                2860


Arg Trp Ser Asp Met Ser Gly Asp Ser Ser Ala Thr Gln Lys Lys Leu 
2865                2870                2875                2880


Ser Lys Ile Lys Glu Leu Ile Asp Ser Arg Glu Ile Gly Ala Ser Arg 
                2885                2890                2895


Leu Ser Arg Val Glu Ser Leu Ala Pro Glu Val Lys Gln Asn Thr Thr 
            2900                2905                2910


Ala Ser Gly Cys Glu Leu Met His Thr Glu Met Gln Ala Leu Arg Ala 
        2915                2920                2925


Asp Trp Lys Gln Trp Glu Asp Ser Val Phe Gln Thr Gln Ser Cys Leu 
    2930                2935                2940


Glu Asn Leu Val Ser Gln Met Ala Leu Ser Glu Gln Glu Phe Ser Gly 
2945                2950                2955                2960


Gln Val Ala Gln Leu Glu Gln Ala Leu Glu Gln Phe Ser Ala Leu Leu 
                2965                2970                2975


Lys Thr Trp Ala Gln Gln Leu Thr Leu Leu Glu Gly Lys Asn Thr Asp 
            2980                2985                2990


Glu Glu Ile Val Glu Cys Trp His Lys Gly Gln Glu Ile Leu Asp Ala 
        2995                3000                3005


Leu Gln Lys Ala Glu Pro Arg Thr Glu Asp Leu Lys Ser Gln Leu Asn 
    3010                3015                3020


Glu Leu Cys Arg Phe Ser Arg Asp Leu Ser Thr Tyr Ser Gly Lys Val 
3025                3030                3035                3040


Ser Gly Leu Ile Lys Glu Tyr Asn Cys Leu Cys Leu Gln Ala Ser Lys 
                3045                3050                3055


Gly Cys Gln Asn Lys Glu Gln Ile Leu Gln Gln Arg Phe Arg Lys Ala 
            3060                3065                3070


Phe Arg Asp Phe Gln Gln Trp Leu Val Asn Ala Lys Ile Thr Thr Ala 
        3075                3080                3085


Lys Cys Phe Asp Ile Pro Gln Asn Ile Ser Glu Val Ser Thr Ser Leu 
    3090                3095                3100


Gln Lys Ile Gln Glu Phe Leu Ser Glu Ser Glu Asn Gly Gln His Lys 
3105                3110                3115                3120


Leu Asn Met Met Leu Ser Lys Gly Glu Leu Leu Ser Thr Leu Leu Thr 
                3125                3130                3135


Lys Glu Lys Ala Lys Gly Ile Gln Ala Lys Val Thr Ala Ala Lys Glu 
            3140                3145                3150


Asp Trp Lys Asn Phe His Ser Asn Leu His Gln Lys Glu Ser Ala Leu 
        3155                3160                3165


Glu Asn Leu Lys Ile Gln Met Lys Asp Phe Glu Val Ser Ala Glu Pro 
    3170                3175                3180


Ile Gln Asp Trp Leu Ser Lys Thr Glu Lys Met Val His Glu Ser Ser 
3185                3190                3195                3200


Asn Arg Leu Tyr Asp Leu Pro Ala Lys Arg Arg Glu Gln Gln Lys Leu 
                3205                3210                3215


Gln Ser Val Leu Glu Glu Ile His Cys Tyr Glu Pro Gln Leu Asn Arg 
            3220                3225                3230


Leu Lys Glu Lys Ala Gln Gln Leu Trp Glu Gly Gln Ala Ala Ser Lys 
        3235                3240                3245


Ser Phe Arg His Arg Val Ser Gln Leu Ser Ser Gln Tyr Leu Ala Leu 
    3250                3255                3260


Ser Asn Leu Thr Lys Glu Lys Val Ser Arg Leu Asp Arg Ile Val Ala 
3265                3270                3275                3280


Glu His Asn Gln Phe Ser Leu Gly Ile Lys Glu Leu Gln Asp Trp Met 
                3285                3290                3295


Thr Asp Ala Ile His Met Leu Asp Ser Tyr Cys His Pro Thr Ser Asp 
            3300                3305                3310


Lys Ser Val Leu Asp Ser Arg Thr Leu Lys Leu Glu Ala Leu Leu Ser 
        3315                3320                3325


Val Lys Gln Glu Lys Glu Ile Gln Met Lys Met Ile Val Thr Arg Gly 
    3330                3335                3340


Glu Ser Val Leu Gln Asn Thr Ser Pro Glu Gly Ile Pro Thr Ile Gln 
3345                3350                3355                3360


Gln Gln Leu Gln Ser Val Lys Asp Met Trp Ala Ser Leu Leu Ser Ala 
                3365                3370                3375


Gly Ile Arg Cys Lys Ser Gln Leu Glu Gly Ala Leu Ser Lys Trp Thr 
            3380                3385                3390


Ser Tyr Gln Asp Gly Val Arg Gln Phe Ser Gly Trp Met Asp Ser Met 
        3395                3400                3405


Glu Ala Asn Leu Asn Glu Ser Glu Arg Gln His Ala Glu Leu Arg Asp 
    3410                3415                3420


Lys Thr Thr Met Leu Gly Lys Ala Lys Leu Leu Asn Glu Glu Val Leu 
3425                3430                3435                3440


Ser Tyr Ser Ser Leu Leu Glu Thr Ile Glu Val Lys Gly Ala Gly Met 
                3445                3450                3455


Thr Glu His Tyr Val Thr Gln Leu Glu Leu Gln Asp Leu Gln Glu Arg 
            3460                3465                3470


Tyr Arg Ala Ile Gln Glu Arg Ala Lys Glu Ala Val Thr Lys Ser Glu 
        3475                3480                3485


Lys Leu Val Arg Leu His Gln Glu Tyr Gln Arg Asp Leu Lys Ala Phe 
    3490                3495                3500


Glu Val Trp Leu Gly Gln Glu Gln Glu Lys Leu Asp Gln Tyr Ser Val 
3505                3510                3515                3520


Leu Glu Gly Asp Ala His Thr His Glu Thr Thr Leu Arg Asp Leu Gln 
                3525                3530                3535


Glu Leu Gln Val His Cys Ala Glu Gly Gln Ala Leu Leu Asn Ser Val 
            3540                3545                3550


Leu His Thr Arg Glu Asp Val Ile Pro Ser Gly Ile Pro Gln Ala Glu 
        3555                3560                3565


Asp Arg Ala Leu Glu Ser Leu Arg Gln Asp Trp Gln Ala Tyr Gln His 
    3570                3575                3580


Arg Leu Ser Glu Thr Arg Thr Gln Phe Asn Asn Val Val Asn Lys Leu 
3585                3590                3595                3600


Arg Leu Met Glu Gln Lys Phe Gln Gln Val Asp Glu Trp Leu Lys Thr 
                3605                3610                3615


Ala Glu Glu Lys Val Ser Pro Arg Thr Arg Arg Gln Ser Asn Arg Ala 
            3620                3625                3630


Thr Lys Glu Ile Gln Leu His Gln Met Lys Lys Trp His Glu Glu Val 
        3635                3640                3645


Thr Ala Tyr Arg Asp Glu Val Glu Glu Val Gly Ala Arg Ala Gln Glu 
    3650                3655                3660


Ile Leu Asp Glu Ser His Val Asn Ser Arg Met Gly Cys Gln Ala Thr 
3665                3670                3675                3680


Gln Leu Thr Ser Arg Tyr Gln Ala Leu Leu Leu Gln Val Leu Glu Gln 
                3685                3690                3695


Ile Lys Phe Leu Glu Glu Glu Ile Gln Ser Leu Glu Glu Ser Glu Ser 
            3700                3705                3710


Ser Leu Ser Ser Tyr Ser Asp Trp Tyr Gly Ser Thr His Lys Asn Phe 
        3715                3720                3725


Lys Asn Val Ala Thr Lys Ile Asp Lys Val Asp Thr Val Met Met Gly 
    3730                3735                3740


Lys Lys Leu Lys Thr Leu Glu Val Leu Leu Lys Asp Met Glu Lys Gly 
3745                3750                3755                3760


His Ser Leu Leu Lys Ser Ala Arg Glu Lys Gly Glu Arg Ala Val Lys 
                3765                3770                3775


Tyr Leu Glu Glu Gly Glu Ala Glu Arg Leu Arg Lys Glu Ile His Asp 
            3780                3785                3790


His Met Glu Gln Leu Lys Glu Leu Thr Ser Thr Val Arg Lys Glu His 
        3795                3800                3805


Met Thr Leu Glu Lys Gly Leu His Leu Ala Lys Glu Phe Ser Asp Lys 
    3810                3815                3820


Cys Lys Ala Leu Thr Gln Trp Ile Ala Glu Tyr Gln Glu Ile Leu His 
3825                3830                3835                3840


Val Pro Glu Glu Pro Lys Met Glu Leu Tyr Glu Lys Lys Ala Gln Leu 
                3845                3850                3855


Ser Lys Tyr Lys Ser Leu Gln Gln Thr Val Leu Ser His Glu Pro Ser 
            3860                3865                3870


Val Lys Ser Val Arg Glu Lys Gly Glu Ala Leu Leu Glu Leu Val Gln 
        3875                3880                3885


Asp Val Thr Leu Lys Asp Lys Ile Asp Gln Leu Gln Ser Asp Tyr Gln 
    3890                3895                3900


Asp Leu Cys Ser Ile Gly Lys Glu His Val Phe Ser Leu Glu Ala Lys 
3905                3910                3915                3920


Val Lys Asp His Glu Asp Tyr Asn Ser Glu Leu Gln Glu Val Glu Lys 
                3925                3930                3935


Trp Leu Leu Gln Met Ser Gly Arg Leu Val Ala Pro Asp Leu Leu Glu 
            3940                3945                3950


Thr Ser Ser Leu Glu Thr Ile Thr Gln Gln Leu Ala His His Lys Ala 
        3955                3960                3965


Met Met Glu Glu Ile Ala Gly Phe Glu Asp Arg Leu Asn Asn Leu Gln 
    3970                3975                3980


Met Lys Gly Asp Thr Leu Ile Gly Gln Cys Ala Asp His Leu Gln Ala 
3985                3990                3995                4000


Lys Leu Lys Gln Asn Val His Ala His Leu Gln Gly Thr Lys Asp Ser 
                4005                4010                4015


Tyr Ser Ala Ile Cys Ser Thr Ala Gln Arg Met Tyr Gln Ser Leu Glu 
            4020                4025                4030


His Glu Leu Gln Lys His Val Ser Arg Gln Asp Thr Leu Gln Gln Cys 
        4035                4040                4045


Gln Ala Trp Leu Ser Ala Val Gln Pro Asp Leu Glu Pro Ser Pro Gln 
    4050                4055                4060


Pro Pro Leu Ser Arg Ala Glu Ala Ile Lys Gln Val Lys His Phe Arg 
4065                4070                4075                4080


Ala Leu Gln Glu Gln Ala Arg Thr Tyr Leu Asp Leu Leu Cys Ser Met 
                4085                4090                4095


Cys Asp Leu Ser Asn Ala Ser Val Lys Thr Thr Ala Lys Asp Ile Gln 
            4100                4105                4110


Gln Thr Glu Gln Thr Ile Glu Gln Lys Leu Val Gln Ala Gln Asn Leu 
        4115                4120                4125


Thr Gln Gly Trp Glu Glu Ile Lys His Leu Lys Ser Glu Leu Trp Ile 
    4130                4135                4140


Tyr Leu Gln Asp Ala Asp Gln Gln Leu Gln Asn Met Lys Arg Arg His 
4145                4150                4155                4160


Ser Glu Leu Glu Leu Asn Ile Ala Gln Asn Met Val Ser Gln Val Lys 
                4165                4170                4175


Asp Phe Val Lys Lys Leu Gln Ser Lys Gln Ala Ser Val Asn Thr Ile 
            4180                4185                4190


Ile Glu Lys Val Asn Lys Leu Thr Lys Lys Glu Glu Ser Pro Glu His 
        4195                4200                4205


Lys Glu Ile Asn His Leu Asn Asp Gln Trp Leu Asp Leu Cys Arg Gln 
    4210                4215                4220


Ser Asn Asn Leu Cys Leu Gln Arg Glu Glu Asp Leu Gln Arg Thr Arg 
4225                4230                4235                4240


Asp Tyr His Asp Cys Met Asn Val Val Glu Val Phe Leu Glu Lys Phe 
                4245                4250                4255


Thr Thr Glu Trp Asp Asn Leu Ala Arg Ser Asp Ala Glu Ser Thr Ala 
            4260                4265                4270


Val His Leu Glu Ala Leu Lys Lys Leu Ala Leu Ala Leu Gln Glu Arg 
        4275                4280                4285


Lys Tyr Ala Ile Glu Asp Leu Lys Asp Gln Lys Gln Lys Met Ile Glu 
    4290                4295                4300


His Leu Asn Leu Asp Asp Lys Glu Leu Val Lys Glu Gln Thr Ser His 
4305                4310                4315                4320


Leu Glu Gln Arg Trp Phe Gln Leu Glu Asp Leu Ile Lys Arg Lys Ile 
                4325                4330                4335


Gln Val Ser Val Thr Asn Leu Glu Glu Leu Asn Val Val Gln Ser Arg 
            4340                4345                4350


Phe Gln Glu Leu Met Glu Trp Ala Glu Glu Gln Gln Pro Asn Ile Ala 
        4355                4360                4365


Glu Ala Leu Lys Gln Ser Pro Pro Pro Asp Met Ala Gln Asn Leu Leu 
    4370                4375                4380


Met Asp His Leu Ala Ile Cys Ser Glu Leu Glu Ala Lys Gln Met Leu 
4385                4390                4395                4400


Leu Lys Ser Leu Ile Lys Asp Ala Asp Arg Val Met Ala Asp Leu Gly 
                4405                4410                4415


Leu Asn Glu Arg Gln Val Ile Gln Lys Ala Leu Ser Asp Ala Gln Ser 
            4420                4425                4430


His Val Asn Cys Leu Ser Asp Leu Val Gly Gln Arg Arg Lys Tyr Leu 
        4435                4440                4445


Asn Lys Ala Leu Ser Glu Lys Thr Gln Phe Leu Met Ala Val Phe Gln 
    4450                4455                4460


Ala Thr Ser Gln Ile Gln Gln His Glu Arg Lys Ile Met Phe Arg Glu 
4465                4470                4475                4480


His Ile Cys Leu Leu Pro Asp Asp Val Ser Lys Gln Val Lys Thr Cys 
                4485                4490                4495


Lys Ser Ala Gln Ala Ser Leu Lys Thr Tyr Gln Asn Glu Val Thr Gly 
            4500                4505                4510


Leu Trp Ala Gln Gly Arg Glu Leu Met Lys Glu Val Thr Glu Gln Glu 
        4515                4520                4525


Lys Ser Glu Val Leu Gly Lys Leu Gln Glu Leu Gln Ser Val Tyr Asp 
    4530                4535                4540


Ser Val Leu Gln Lys Cys Ser His Arg Leu Gln Glu Leu Glu Lys Asn 
4545                4550                4555                4560


Leu Val Ser Arg Lys His Phe Lys Glu Asp Phe Asp Lys Ala Cys His 
                4565                4570                4575


Trp Leu Lys Gln Ala Asp Ile Val Thr Phe Pro Glu Ile Asn Leu Met 
            4580                4585                4590


Asn Glu Ser Ser Glu Leu His Thr Gln Leu Ala Lys Tyr Gln Asn Ile 
        4595                4600                4605


Leu Glu Gln Ser Pro Glu Tyr Glu Asn Leu Leu Leu Thr Leu Gln Arg 
    4610                4615                4620


Thr Gly Gln Thr Ile Leu Pro Ser Leu Asn Glu Val Asp His Ser Tyr 
4625                4630                4635                4640


Leu Ser Glu Lys Leu Asn Ala Leu Pro Arg Gln Phe Asn Val Ile Val 
                4645                4650                4655


Ala Leu Ala Lys Asp Lys Phe Tyr Lys Val Gln Glu Ala Ile Leu Ala 
            4660                4665                4670


Arg Lys Glu Tyr Ala Ser Leu Ile Glu Leu Thr Thr Gln Ser Leu Ser 
        4675                4680                4685


Glu Leu Glu Ala Gln Phe Leu Arg Met Ser Lys Val Pro Thr Asp Leu 
    4690                4695                4700


Ala Val Glu Glu Ala Leu Ser Leu Gln Asp Gly Cys Arg Ala Ile Leu 
4705                4710                4715                4720


Asp Glu Val Ala Gly Leu Gly Glu Ala Val Asp Glu Leu Asn Gln Lys 
                4725                4730                4735


Lys Glu Gly Phe Arg Ser Thr Gly Gln Pro Trp Gln Pro Asp Lys Met 
            4740                4745                4750


Leu His Leu Val Thr Leu Tyr His Arg Leu Lys Arg Gln Thr Glu Gln 
        4755                4760                4765


Arg Val Ser Leu Leu Glu Asp Thr Thr Ser Ala Tyr Gln Glu His Glu 
    4770                4775                4780


Lys Met Cys Gln Gln Leu Glu Arg Gln Leu Lys Ser Val Lys Glu Glu 
4785                4790                4795                4800


Gln Ser Lys Val Asn Glu Glu Thr Leu Pro Ala Glu Glu Lys Leu Lys 
                4805                4810                4815


Met Tyr His Ser Leu Ala Gly Ser Leu Gln Asp Ser Gly Ile Val Leu 
            4820                4825                4830


Lys Arg Val Thr Ile His Leu Glu Asp Leu Ala Pro His Leu Asp Pro 
        4835                4840                4845


Leu Ala Tyr Glu Lys Ala Arg His Gln Ile Gln Ser Trp Gln Gly Glu 
    4850                4855                4860


Leu Lys Leu Leu Thr Ser Ala Ile Gly Glu Thr Val Thr Glu Cys Glu 
4865                4870                4875                4880


Ser Arg Met Val Gln Ser Ile Asp Phe Gln Thr Glu Met Ser Arg Ser 
                4885                4890                4895


Leu Asp Trp Leu Arg Arg Val Lys Ala Glu Leu Ser Gly Pro Val Tyr 
            4900                4905                4910


Leu Asp Leu Asn Leu Gln Asp Ile Gln Glu Glu Ile Arg Lys Ile Gln 
        4915                4920                4925


Ile His Gln Glu Glu Val Gln Ser Ser Leu Arg Ile Met Asn Ala Leu 
    4930                4935                4940


Ser His Lys Glu Lys Glu Lys Phe Thr Lys Ala Lys Glu Leu Ile Ser 
4945                4950                4955                4960


Ala Asp Leu Glu His Ser Leu Ala Glu Leu Ser Glu Leu Asp Gly Asp 
                4965                4970                4975


Ile Gln Glu Ala Leu Arg Thr Arg Gln Ala Thr Leu Thr Glu Ile Tyr 
            4980                4985                4990


Ser Gln Cys Gln Arg Tyr Tyr Gln Val Phe Gln Ala Ala Asn Asp Trp 
        4995                5000                5005


Leu Glu Asp Ala Gln Glu Leu Leu Gln Leu Ala Gly Asn Gly Leu Asp 
    5010                5015                5020


Val Glu Ser Ala Glu Glu Asn Leu Lys Ser His Met Glu Phe Phe Ser 
5025                5030                5035                5040


Thr Glu Asp Gln Phe His Ser Asn Leu Glu Glu Leu His Ser Leu Val 
                5045                5050                5055


Ala Thr Leu Asp Pro Leu Ile Lys Pro Thr Gly Lys Glu Asp Leu Glu 
            5060                5065                5070


Gln Lys Val Ala Ser Leu Glu Leu Arg Ser Gln Arg Met Ser Arg Asp 
        5075                5080                5085


Ser Gly Ala Gln Val Asp Leu Leu Gln Arg Cys Thr Ala Gln Trp His 
    5090                5095                5100


Asp Tyr Gln Lys Ala Arg Glu Glu Val Ile Glu Leu Met Asn Asp Thr 
5105                5110                5115                5120


Glu Lys Lys Leu Ser Glu Phe Ser Leu Leu Lys Thr Ser Ser Ser His 
                5125                5130                5135


Glu Ala Glu Glu Lys Leu Ser Glu His Lys Ala Leu Val Ser Val Val 
            5140                5145                5150


Asn Ser Phe His Glu Lys Ile Val Ala Leu Glu Glu Lys Ala Ser Gln 
        5155                5160                5165


Leu Glu Lys Thr Gly Asn Asp Ala Ser Lys Ala Thr Leu Ser Arg Ser 
    5170                5175                5180


Met Thr Thr Val Trp Gln Arg Trp Thr Arg Leu Arg Ala Val Ala Gln 
5185                5190                5195                5200


Asp Gln Glu Lys Ile Leu Glu Asp Ala Val Asp Glu Trp Thr Gly Phe 
                5205                5210                5215


Asn Asn Lys Val Lys Lys Ala Thr Glu Met Ile Asp Gln Leu Gln Asp 
            5220                5225                5230


Lys Leu Pro Gly Ser Ser Ala Glu Lys Ala Ser Lys Ala Glu Leu Leu 
        5235                5240                5245


Thr Leu Leu Glu Tyr His Asp Thr Phe Val Leu Glu Leu Glu Gln Gln 
    5250                5255                5260


Gln Ser Ala Leu Gly Met Leu Arg Gln Gln Thr Leu Ser Met Leu Gln 
5265                5270                5275                5280


Asp Gly Ala Ala Pro Thr Pro Gly Glu Glu Pro Pro Leu Met Gln Glu 
                5285                5290                5295


Ile Thr Ala Met Gln Asp Arg Cys Leu Asn Met Gln Glu Lys Val Lys 
            5300                5305                5310


Thr Asn Gly Lys Leu Val Lys Gln Glu Leu Lys Asp Arg Glu Met Val 
        5315                5320                5325


Glu Thr Gln Ile Asn Ser Val Lys Cys Trp Val Gln Glu Thr Lys Glu 
    5330                5335                5340


Tyr Leu Gly Asn Pro Thr Ile Glu Ile Asp Ala Gln Leu Glu Glu Leu 
5345                5350                5355                5360


Gln Ile Leu Leu Thr Glu Ala Thr Asn His Arg Gln Asn Ile Glu Lys 
                5365                5370                5375


Met Ala Glu Glu Gln Lys Glu Lys Tyr Leu Gly Leu Tyr Thr Ile Leu 
            5380                5385                5390


Pro Ser Glu Leu Ser Leu Gln Leu Ala Glu Val Ala Leu Asp Leu Lys 
        5395                5400                5405


Ile Arg Asp Gln Ile Gln Asp Lys Ile Lys Glu Val Glu Gln Ser Lys 
    5410                5415                5420


Ala Thr Ser Gln Glu Leu Ser Arg Gln Ile Gln Lys Leu Ala Lys Asp 
5425                5430                5435                5440


Leu Thr Thr Ile Leu Thr Lys Leu Lys Ala Lys Thr Asp Asn Val Val 
                5445                5450                5455


Gln Ala Lys Thr Asp Gln Lys Val Leu Gly Glu Glu Leu Asp Gly Cys 
            5460                5465                5470


Asn Ser Lys Leu Met Glu Leu Asp Ala Ala Val Gln Lys Phe Leu Glu 
        5475                5480                5485


Gln Asn Gly Gln Leu Gly Lys Pro Leu Ala Lys Lys Ile Gly Lys Leu 
    5490                5495                5500


Thr Glu Leu His Gln Gln Thr Ile Arg Gln Ala Glu Asn Arg Leu Ser 
5505                5510                5515                5520


Lys Leu Asn Gln Ala Ala Ser His Leu Glu Glu Tyr Asn Glu Met Leu 
                5525                5530                5535


Glu Leu Ile Leu Lys Trp Ile Glu Lys Ala Lys Val Leu Ala His Gly 
            5540                5545                5550


Thr Ile Ala Trp Asn Ser Ala Ser Gln Leu Arg Glu Gln Tyr Ile Leu 
        5555                5560                5565


His Gln Thr Leu Leu Glu Glu Ser Lys Glu Ile Asp Ser Glu Leu Glu 
    5570                5575                5580


Ala Met Thr Glu Lys Leu Gln Tyr Leu Thr Ser Val Tyr Cys Thr Glu 
5585                5590                5595                5600


Lys Met Ser Gln Gln Val Ala Glu Leu Gly Arg Glu Thr Glu Glu Leu 
                5605                5610                5615


Arg Gln Met Ile Lys Ile Arg Leu Gln Asn Leu Gln Asp Ala Ala Lys 
            5620                5625                5630


Asp Met Lys Lys Phe Glu Ala Glu Leu Lys Lys Leu Gln Ala Ala Leu 
        5635                5640                5645


Glu Gln Ala Gln Ala Thr Leu Thr Ser Pro Glu Val Gly Arg Leu Ser 
    5650                5655                5660


Leu Lys Glu Gln Leu Ser His Arg Gln His Leu Leu Ser Glu Met Glu 
5665                5670                5675                5680


Ser Leu Lys Pro Lys Val Gln Ala Val Gln Leu Cys Gln Ser Ala Leu 
                5685                5690                5695


Arg Ile Pro Glu Asp Val Val Ala Ser Leu Pro Leu Cys His Ala Ala 
            5700                5705                5710


Leu Arg Leu Gln Glu Glu Ala Ser Arg Leu Gln His Thr Ala Ile Gln 
        5715                5720                5725


Gln Cys Asn Ile Met Gln Ala Ala Val Val Gln Tyr Glu Gln Tyr Glu 
    5730                5735                5740


Gln Glu Met Lys His Leu Gln Gln Leu Ile Glu Gly Ala His Arg Glu 
5745                5750                5755                5760


Ile Glu Asp Lys Pro Val Ala Thr Ser Asn Ile Gln Glu Leu Gln Ala 
                5765                5770                5775


Gln Ile Ser Arg His Glu Glu Leu Ala Gln Lys Ile Lys Gly Tyr Gln 
            5780                5785                5790


Glu Gln Ile Ala Ser Leu Asn Ser Lys Cys Lys Met Leu Thr Met Lys 
        5795                5800                5805


Ala Lys His Ala Thr Met Leu Leu Thr Val Thr Glu Val Glu Gly Leu 
    5810                5815                5820


Ala Glu Gly Thr Glu Asp Leu Asp Gly Glu Leu Leu Pro Thr Pro Ser 
5825                5830                5835                5840


Ala His Pro Ser Val Val Met Met Thr Ala Gly Arg Cys His Thr Leu 
                5845                5850                5855


Leu Ser Pro Val Thr Glu Glu Ser Gly Glu Glu Gly Thr Asn Ser Glu 
            5860                5865                5870


Ile Ser Ser Pro Pro Ala Cys Arg Ser Pro Ser Pro Val Ala Asn Thr 
        5875                5880                5885


Asp Ala Ser Val Asn Gln Asp Ile Ala Tyr Tyr Gln Ala Leu Ser Ala 
    5890                5895                5900


Glu Arg Leu Gln Thr Asp Ala Ala Lys Ile His Pro Ser Thr Ser Ala 
5905                5910                5915                5920


Ser Gln Glu Phe Tyr Glu Pro Gly Leu Glu Pro Ser Ala Thr Ala Lys 
                5925                5930                5935


Leu Gly Asp Leu Gln Arg Ser Trp Glu Thr Leu Lys Asn Val Ile Ser 
            5940                5945                5950


Glu Lys Gln Arg Thr Leu Tyr Glu Ala Leu Glu Arg Gln Gln Lys Tyr 
        5955                5960                5965


Gln Asp Ser Leu Gln Ser Ile Ser Thr Lys Met Glu Ala Ile Glu Leu 
    5970                5975                5980


Lys Leu Ser Glu Ser Pro Glu Pro Gly Arg Ser Pro Glu Ser Gln Met 
5985                5990                5995                6000


Ala Glu His Gln Ala Leu Met Asp Glu Ile Leu Met Leu Gln Asp Glu 
                6005                6010                6015


Ile Asn Glu Leu Gln Ser Ser Leu Ala Glu Glu Leu Val Ser Glu Ser 
            6020                6025                6030


Cys Glu Ala Asp Pro Ala Glu Gln Leu Ala Leu Gln Ser Thr Leu Thr 
        6035                6040                6045


Val Leu Ala Glu Arg Met Ser Thr Ile Arg Met Lys Ala Ser Gly Lys 
    6050                6055                6060


Arg Gln Leu Leu Glu Glu Lys Leu Asn Asp Gln Leu Glu Glu Gln Arg 
6065                6070                6075                6080


Gln Glu Gln Ala Leu Gln Arg Tyr Arg Cys Glu Ala Asp Glu Leu Asp 
                6085                6090                6095


Ser Trp Leu Leu Ser Thr Lys Ala Thr Leu Asp Thr Ala Leu Ser Pro 
            6100                6105                6110


Pro Lys Glu Pro Met Asp Met Glu Ala Gln Leu Met Asp Cys Gln Asn 
        6115                6120                6125


Met Leu Val Glu Ile Glu Gln Lys Val Val Ala Leu Ser Glu Leu Ser 
    6130                6135                6140


Val His Asn Glu Asn Leu Leu Leu Glu Gly Lys Ala His Thr Lys Asp 
6145                6150                6155                6160


Glu Ala Glu Gln Leu Ala Gly Lys Leu Arg Arg Leu Lys Gly Ser Leu 
                6165                6170                6175


Leu Glu Leu Gln Arg Ala Leu His Asp Lys Gln Leu Asn Met Gln Gly 
            6180                6185                6190


Thr Ala Gln Glu Lys Glu Glu Ser Asp Val Asp Leu Thr Ala Thr Gln 
        6195                6200                6205


Ser Pro Gly Val Gln Glu Trp Leu Ala Gln Ala Arg Thr Thr Trp Thr 
    6210                6215                6220


Gln Gln Arg Gln Ser Ser Leu Gln Gln Gln Lys Glu Leu Glu Gln Glu 
6225                6230                6235                6240


Leu Ala Glu Gln Lys Ser Leu Leu Arg Ser Val Ala Ser Arg Gly Glu 
                6245                6250                6255


Glu Ile Leu Ile Gln His Ser Ala Ala Glu Thr Ser Gly Asp Ala Gly 
            6260                6265                6270


Glu Lys Pro Asp Val Leu Ser Gln Glu Leu Gly Met Glu Gly Glu Lys 
        6275                6280                6285


Ser Ser Ala Glu Asp Gln Met Arg Met Lys Trp Glu Ser Leu His Gln 
    6290                6295                6300


Glu Phe Ser Thr Lys Gln Lys Leu Leu Gln Asn Val Leu Glu Gln Glu 
6305                6310                6315                6320


Gln Glu Gln Val Leu Tyr Ser Arg Pro Asn Arg Leu Leu Ser Gly Val 
                6325                6330                6335


Pro Leu Tyr Lys Gly Asp Val Pro Thr Gln Asp Lys Ser Ala Val Thr 
            6340                6345                6350


Ser Leu Leu Asp Gly Leu Asn Gln Ala Phe Glu Glu Val Ser Ser Gln 
        6355                6360                6365


Ser Gly Gly Ala Lys Arg Gln Ser Ile His Leu Glu Gln Lys Leu Tyr 
    6370                6375                6380


Asp Gly Val Ser Ala Thr Ser Thr Trp Leu Asp Asp Val Glu Glu Arg 
6385                6390                6395                6400


Leu Phe Val Ala Thr Ala Leu Leu Pro Glu Glu Thr Glu Thr Cys Leu 
                6405                6410                6415


Phe Asn Gln Glu Ile Leu Ala Lys Asp Ile Lys Glu Met Ser Glu Glu 
            6420                6425                6430


Met Asp Lys Asn Lys Asn Leu Phe Ser Gln Ala Phe Pro Glu Asn Gly 
        6435                6440                6445


Asp Asn Arg Asp Val Ile Glu Asp Thr Leu Gly Cys Leu Leu Gly Arg 
    6450                6455                6460


Leu Ser Leu Leu Asp Ser Val Val Asn Gln Arg Cys His Gln Met Lys 
6465                6470                6475                6480


Glu Arg Leu Gln Gln Ile Leu Asn Phe Gln Asn Asp Leu Lys Val Leu 
                6485                6490                6495


Phe Thr Ser Leu Ala Asp Asn Lys Tyr Ile Ile Leu Gln Lys Leu Ala 
            6500                6505                6510


Asn Val Phe Glu Gln Pro Val Ala Glu Gln Ile Glu Ala Ile Gln Gln 
        6515                6520                6525


Ala Glu Asp Gly Leu Lys Glu Phe Asp Ala Gly Ile Ile Glu Leu Lys 
    6530                6535                6540


Arg Arg Gly Asp Lys Leu Gln Val Glu Gln Pro Ser Met Gln Glu Leu 
6545                6550                6555                6560


Ser Lys Leu Gln Asp Met Tyr Asp Glu Leu Met Met Ile Ile Gly Ser 
                6565                6570                6575


Arg Arg Ser Gly Leu Asn Gln Asn Leu Thr Leu Lys Ser Gln Tyr Glu 
            6580                6585                6590


Arg Ala Leu Gln Asp Leu Ala Asp Leu Leu Glu Thr Gly Gln Glu Lys 
        6595                6600                6605


Met Ala Gly Asp Gln Lys Ile Ile Val Ser Ser Lys Glu Glu Ile Gln 
    6610                6615                6620


Gln Leu Leu Asp Lys His Lys Glu Tyr Phe Gln Gly Leu Glu Ser His 
6625                6630                6635                6640


Met Ile Leu Thr Glu Thr Leu Phe Arg Lys Ile Ile Ser Phe Ala Val 
                6645                6650                6655


Gln Lys Glu Thr Gln Phe His Thr Glu Leu Met Ala Gln Ala Ser Ala 
            6660                6665                6670


Val Leu Lys Arg Ala His Lys Arg Gly Val Glu Leu Glu Tyr Ile Leu 
        6675                6680                6685


Glu Thr Trp Ser His Leu Asp Glu Asp Gln Gln Glu Leu Ser Arg Gln 
    6690                6695                6700


Leu Glu Val Val Glu Ser Ser Ile Pro Ser Val Gly Leu Val Glu Glu 
6705                6710                6715                6720


Asn Glu Asp Arg Leu Ile Asp Arg Ile Thr Leu Tyr Gln His Leu Lys 
                6725                6730                6735


Ser Ser Leu Asn Glu Tyr Gln Pro Lys Leu Tyr Gln Val Leu Asp Asp 
            6740                6745                6750


Gly Lys Arg Leu Leu Ile Ser Ile Ser Cys Ser Asp Leu Glu Ser Gln 
        6755                6760                6765


Leu Asn Gln Leu Gly Glu Cys Trp Leu Ser Asn Thr Asn Lys Met Ser 
    6770                6775                6780


Lys Glu Leu His Arg Leu Glu Thr Ile Leu Lys His Trp Thr Arg Tyr 
6785                6790                6795                6800


Gln Ser Glu Ser Ala Asp Leu Ile His Trp Leu Gln Ser Ala Lys Asp 
                6805                6810                6815


Arg Leu Glu Phe Trp Thr Gln Gln Ser Val Thr Val Pro Gln Glu Leu 
            6820                6825                6830


Glu Met Val Arg Asp His Leu Asn Ala Phe Leu Glu Phe Ser Lys Glu 
        6835                6840                6845


Val Asp Ala Gln Ser Ser Leu Lys Ser Ser Val Leu Ser Thr Gly Asn 
    6850                6855                6860


Gln Leu Leu Arg Leu Lys Lys Val Asp Thr Ala Thr Leu Arg Ser Glu 
6865                6870                6875                6880


Leu Ser Arg Ile Asp Ser Gln Trp Thr Asp Leu Leu Thr Asn Ile Pro 
                6885                6890                6895


Ala Val Gln Glu Lys Leu His Gln Leu Gln Met Asp Lys Leu Pro Ser 
            6900                6905                6910


Arg His Ala Ile Ser Glu Val Met Ser Trp Ile Ser Leu Met Glu Asn 
        6915                6920                6925


Val Ile Gln Lys Asp Glu Asp Asn Ile Lys Asn Ser Ile Gly Tyr Lys 
    6930                6935                6940


Ala Ile His Glu Tyr Leu Gln Lys Tyr Lys Gly Phe Lys Ile Asp Ile 
6945                6950                6955                6960


Asn Cys Lys Gln Leu Thr Val Asp Phe Val Asn Gln Ser Val Leu Gln 
                6965                6970                6975


Ile Ser Ser Gln Asp Val Glu Ser Lys Arg Ser Asp Lys Thr Asp Phe 
            6980                6985                6990


Ala Glu Gln Leu Gly Ala Met Asn Lys Ser Trp Gln Ile Leu Gln Gly 
        6995                7000                7005


Leu Val Thr Glu Lys Ile Gln Leu Leu Glu Gly Leu Leu Glu Ser Trp 
    7010                7015                7020


Ser Glu Tyr Glu Asn Asn Val Gln Cys Leu Lys Thr Trp Phe Glu Thr 
7025                7030                7035                7040


Gln Glu Lys Arg Leu Lys Gln Gln His Arg Ile Gly Asp Gln Ala Ser 
                7045                7050                7055


Val Gln Asn Ala Leu Lys Asp Cys Gln Asp Leu Glu Asp Leu Ile Lys 
            7060                7065                7070


Ala Lys Glu Lys Glu Val Glu Lys Ile Glu Gln Asn Gly Leu Ala Leu 
        7075                7080                7085


Ile Gln Asn Lys Lys Glu Asp Val Ser Ser Ile Val Met Ser Thr Leu 
    7090                7095                7100


Arg Glu Leu Gly Gln Thr Trp Ala Asn Leu Asp His Met Val Gly Gln 
7105                7110                7115                7120


Leu Lys Ile Leu Leu Lys Ser Val Leu Asp Gln Trp Ser Ser His Lys 
                7125                7130                7135


Val Ala Phe Asp Lys Ile Asn Ser Tyr Leu Met Glu Ala Arg Tyr Ser 
            7140                7145                7150


Leu Ser Arg Phe Arg Leu Leu Thr Gly Ser Leu Glu Ala Val Gln Val 
        7155                7160                7165


Gln Val Asp Asn Leu Gln Asn Leu Gln Asp Asp Leu Glu Lys Gln Glu 
    7170                7175                7180


Arg Ser Leu Gln Lys Phe Gly Ser Ile Thr Asn Gln Leu Leu Lys Glu 
7185                7190                7195                7200


Cys His Pro Pro Val Thr Glu Thr Leu Thr Asn Thr Leu Lys Glu Val 
                7205                7210                7215


Asn Met Arg Trp Asn Asn Leu Leu Glu Glu Ile Ala Glu Gln Leu Gln 
            7220                7225                7230


Ser Ser Lys Ala Leu Leu Gln Leu Trp Gln Arg Tyr Lys Asp Tyr Ser 
        7235                7240                7245


Lys Gln Cys Ala Ser Thr Val Gln Gln Gln Glu Asp Arg Thr Asn Glu 
    7250                7255                7260


Leu Leu Lys Ala Ala Thr Asn Lys Asp Ile Ala Asp Asp Glu Val Ala 
7265                7270                7275                7280


Thr Trp Ile Gln Asp Cys Asn Asp Leu Leu Lys Gly Leu Gly Thr Val 
                7285                7290                7295


Lys Asp Ser Leu Phe Phe Leu His Glu Leu Gly Glu Gln Leu Lys Gln 
            7300                7305                7310


Gln Val Asp Ala Ser Ala Ala Ser Ala Ile Gln Ser Asp Gln Leu Ser 
        7315                7320                7325


Leu Ser Gln His Leu Cys Ala Leu Glu Gln Ala Leu Cys Lys Gln Gln 
    7330                7335                7340


Thr Ser Leu Gln Ala Gly Val Leu Asp Tyr Glu Thr Phe Ala Lys Ser 
7345                7350                7355                7360


Leu Glu Ala Leu Glu Ala Trp Ile Val Glu Ala Glu Glu Ile Leu Gln 
                7365                7370                7375


Gly Gln Asp Pro Ser His Ser Ser Asp Leu Ser Thr Ile Gln Glu Arg 
            7380                7385                7390


Met Glu Glu Leu Lys Gly Gln Met Leu Lys Phe Ser Ser Met Ala Pro 
        7395                7400                7405


Asp Leu Asp Arg Leu Asn Glu Leu Gly Tyr Arg Leu Pro Leu Asn Asp 
    7410                7415                7420


Lys Glu Ile Lys Arg Met Gln Asn Leu Asn Arg His Trp Ser Leu Ile 
7425                7430                7435                7440


Ser Ser Gln Thr Thr Glu Arg Phe Ser Lys Leu Gln Ser Phe Leu Leu 
                7445                7450                7455


Gln His Gln Thr Phe Leu Glu Lys Cys Glu Thr Trp Met Glu Phe Leu 
            7460                7465                7470


Val Gln Thr Glu Gln Lys Leu Ala Val Glu Ile Ser Gly Asn Tyr Gln 
        7475                7480                7485


His Leu Leu Glu Gln Gln Arg Ala His Glu Leu Phe Gln Ala Glu Met 
    7490                7495                7500


Phe Ser Arg Gln Gln Ile Leu His Ser Ile Ile Ile Asp Gly Gln Arg 
7505                7510                7515                7520


Leu Leu Glu Gln Gly Gln Val Asp Asp Arg Asp Glu Phe Asn Leu Lys 
                7525                7530                7535


Leu Thr Leu Leu Ser Asn Gln Trp Gln Gly Val Ile Arg Arg Ala Gln 
            7540                7545                7550


Gln Arg Arg Gly Ile Ile Asp Ser Gln Ile Arg Gln Trp Gln Arg Tyr 
        7555                7560                7565


Arg Glu Met Ala Glu Lys Leu Arg Lys Trp Leu Val Glu Val Ser Tyr 
    7570                7575                7580


Leu Pro Met Ser Gly Leu Gly Ser Val Pro Ile Pro Leu Gln Gln Ala 
7585                7590                7595                7600


Arg Thr Leu Phe Asp Glu Val Gln Phe Lys Glu Lys Val Phe Leu Arg 
                7605                7610                7615


Gln Gln Gly Ser Tyr Ile Leu Thr Val Glu Ala Gly Lys Gln Leu Leu 
            7620                7625                7630


Leu Ser Ala Asp Ser Gly Ala Glu Ala Ala Leu Gln Ala Glu Leu Ala 
        7635                7640                7645


Glu Ile Gln Glu Lys Trp Lys Ser Ala Ser Met Arg Leu Glu Glu Gln 
    7650                7655                7660


Lys Lys Lys Leu Ala Phe Leu Leu Lys Asp Trp Glu Lys Cys Glu Lys 
7665                7670                7675                7680


Gly Ile Ala Asp Ser Leu Glu Lys Leu Arg Thr Phe Lys Lys Lys Leu 
                7685                7690                7695


Ser Gln Ser Leu Pro Asp His His Glu Glu Leu His Ala Glu Gln Met 
            7700                7705                7710


Arg Cys Lys Glu Leu Glu Asn Ala Val Gly Ser Trp Thr Asp Asp Leu 
        7715                7720                7725


Thr Gln Leu Ser Leu Leu Lys Asp Thr Leu Ser Ala Tyr Ile Ser Ala 
    7730                7735                7740


Asp Asp Ile Ser Ile Leu Asn Glu Arg Val Glu Leu Leu Gln Arg Gln 
7745                7750                7755                7760


Trp Glu Glu Leu Cys His Gln Leu Ser Leu Arg Arg Gln Gln Ile Gly 
                7765                7770                7775


Glu Arg Leu Asn Glu Trp Ala Val Phe Ser Glu Lys Asn Lys Glu Leu 
            7780                7785                7790


Cys Glu Trp Leu Thr Gln Met Glu Ser Lys Val Ser Gln Asn Gly Asp 
        7795                7800                7805


Ile Leu Ile Glu Glu Met Ile Glu Lys Leu Lys Lys Asp Tyr Gln Glu 
    7810                7815                7820


Glu Ile Ala Ile Ala Gln Glu Asn Lys Ile Gln Leu Gln Gln Met Gly 
7825                7830                7835                7840


Glu Arg Leu Ala Lys Ala Ser His Glu Ser Lys Ala Ser Glu Ile Glu 
                7845                7850                7855


Tyr Lys Leu Gly Lys Val Asn Asp Arg Trp Gln His Leu Leu Asp Leu 
            7860                7865                7870


Ile Ala Ala Arg Val Lys Lys Leu Lys Glu Thr Leu Val Ala Val Gln 
        7875                7880                7885


Gln Leu Asp Lys Asn Met Ser Ser Leu Arg Thr Trp Leu Ala His Ile 
    7890                7895                7900


Glu Ser Glu Leu Ala Lys Pro Ile Val Tyr Asp Ser Cys Asn Ser Glu 
7905                7910                7915                7920


Glu Ile Gln Arg Lys Leu Asn Glu Gln Gln Glu Leu Gln Arg Asp Ile 
                7925                7930                7935


Glu Lys His Ser Thr Gly Val Ala Ser Val Leu Asn Leu Cys Glu Val 
            7940                7945                7950


Leu Leu His Asp Cys Asp Ala Cys Ala Thr Asp Ala Glu Cys Asp Ser 
        7955                7960                7965


Ile Gln Gln Ala Thr Arg Asn Leu Asp Arg Arg Trp Arg Asn Ile Cys 
    7970                7975                7980


Ala Met Ser Met Glu Arg Arg Leu Lys Ile Glu Glu Thr Trp Arg Leu 
7985                7990                7995                8000


Trp Gln Lys Phe Leu Asp Asp Tyr Ser Arg Phe Glu Asp Trp Leu Lys 
                8005                8010                8015


Ser Ser Glu Arg Thr Ala Ala Phe Pro Ser Ser Ser Gly Val Ile Tyr 
            8020                8025                8030


Thr Val Ala Lys Glu Glu Leu Lys Lys Phe Glu Ala Phe Gln Arg Gln 
        8035                8040                8045


Val His Glu Cys Leu Thr Gln Leu Glu Leu Ile Asn Lys Gln Tyr Arg 
    8050                8055                8060


Arg Leu Ala Arg Glu Asn Arg Thr Asp Ser Ala Cys Ser Leu Lys Gln 
8065                8070                8075                8080


Met Val His Glu Gly Asn Gln Arg Trp Asp Asn Leu Gln Lys Arg Val 
                8085                8090                8095


Thr Ser Ile Leu Arg Arg Leu Lys His Phe Ile Gly Gln Arg Glu Glu 
            8100                8105                8110


Phe Glu Thr Ala Arg Asp Ser Ile Leu Val Trp Leu Thr Glu Met Asp 
        8115                8120                8125


Leu Gln Leu Thr Asn Ile Glu His Phe Ser Glu Cys Asp Val Gln Ala 
    8130                8135                8140


Lys Ile Lys Gln Leu Lys Ala Phe Gln Gln Glu Ile Ser Leu Asn His 
8145                8150                8155                8160


Asn Lys Ile Glu Gln Ile Ile Ala Gln Gly Glu Gln Leu Ile Glu Lys 
                8165                8170                8175


Ser Glu Pro Leu Asp Ala Ala Ile Ile Glu Glu Glu Leu Asp Glu Leu 
            8180                8185                8190


Arg Arg Tyr Cys Gln Glu Val Phe Gly Arg Val Glu Arg Tyr His Lys 
        8195                8200                8205


Lys Leu Ile Arg Leu Pro Leu Pro Asp Asp Glu His Asp Leu Ser Asp 
    8210                8215                8220


Arg Glu Leu Glu Leu Glu Asp Ser Ala Ala Leu Ser Asp Leu His Trp 
8225                8230                8235                8240


His Asp Arg Ser Ala Asp Ser Leu Leu Ser Pro Gln Pro Ser Ser Asn 
                8245                8250                8255


Leu Ser Leu Ser Leu Ala Gln Pro Leu Arg Ser Glu Arg Ser Gly Arg 
            8260                8265                8270


Asp Thr Pro Ala Ser Val Asp Ser Ile Pro Leu Glu Trp Asp His Asp 
        8275                8280                8285


Tyr Asp Leu Ser Arg Asp Leu Glu Ser Ala Met Ser Arg Ala Leu Pro 
    8290                8295                8300


Ser Glu Asp Glu Glu Gly Gln Asp Asp Lys Asp Phe Tyr Leu Arg Gly 
8305                8310                8315                8320


Ala Val Gly Leu Ser Gly Asp His Ser Ala Leu Glu Ser Gln Ile Arg 
                8325                8330                8335


Gln Leu Gly Lys Ala Leu Asp Asp Ser Arg Phe Gln Ile Gln Gln Thr 
            8340                8345                8350


Glu Asn Ile Ile Arg Ser Lys Thr Pro Thr Gly Pro Glu Leu Asp Thr 
        8355                8360                8365


Ser Tyr Lys Gly Tyr Met Lys Leu Leu Gly Glu Cys Ser Ser Ser Ile 
    8370                8375                8380


Asp Ser Val Lys Arg Leu Glu His Lys Leu Lys Glu Glu Glu Glu Ser 
8385                8390                8395                8400


Leu Pro Gly Phe Val Asn Leu His Ser Thr Glu Thr Gln Thr Ala Gly 
                8405                8410                8415


Val Ile Asp Arg Trp Glu Leu Leu Gln Ala Gln Ala Leu Ser Lys Glu 
            8420                8425                8430


Leu Arg Met Lys Gln Asn Leu Gln Lys Trp Gln Gln Phe Asn Ser Asp 
        8435                8440                8445


Leu Asn Ser Ile Trp Ala Trp Leu Gly Asp Thr Glu Glu Glu Leu Glu 
    8450                8455                8460


Gln Leu Gln Arg Leu Glu Leu Ser Thr Asp Ile Gln Thr Ile Glu Leu 
8465                8470                8475                8480


Gln Ile Lys Lys Leu Lys Glu Leu Gln Lys Ala Val Asp His Arg Lys 
                8485                8490                8495


Ala Ile Ile Leu Ser Ile Asn Leu Cys Ser Pro Glu Phe Thr Gln Ala 
            8500                8505                8510


Asp Ser Lys Glu Ser Arg Asp Leu Gln Asp Arg Leu Ser Gln Met Asn 
        8515                8520                8525


Gly Arg Trp Asp Arg Val Cys Ser Leu Leu Glu Glu Trp Arg Gly Leu 
    8530                8535                8540


Leu Gln Asp Ala Leu Met Gln Cys Gln Gly Phe His Glu Met Ser His 
8545                8550                8555                8560


Gly Leu Leu Leu Met Leu Glu Asn Ile Asp Arg Arg Lys Asn Glu Ile 
                8565                8570                8575


Val Pro Ile Asp Ser Asn Leu Asp Ala Glu Ile Leu Gln Asp His His 
            8580                8585                8590


Lys Gln Leu Met Gln Ile Lys His Glu Leu Leu Glu Ser Gln Leu Arg 
        8595                8600                8605


Val Ala Ser Leu Gln Asp Met Ser Cys Gln Leu Leu Val Asn Ala Glu 
    8610                8615                8620


Gly Thr Asp Cys Leu Glu Ala Lys Glu Lys Val His Val Ile Gly Asn 
8625                8630                8635                8640


Arg Leu Lys Leu Leu Leu Lys Glu Val Ser Arg His Ile Lys Glu Leu 
                8645                8650                8655


Glu Lys Leu Leu Asp Val Ser Ser Ser Gln Gln Asp Leu Ser Ser Trp 
            8660                8665                8670


Ser Ser Ala Asp Glu Leu Asp Thr Ser Gly Ser Val Ser Pro Thr Ser 
        8675                8680                8685


Gly Arg Ser Thr Pro Asn Arg Gln Lys Thr Pro Arg Gly Lys Cys Ser 
    8690                8695                8700


Leu Ser Gln Pro Gly Pro Ser Val Ser Ser Pro His Ser Arg Ser Thr 
8705                8710                8715                8720


Lys Gly Gly Ser Asp Ser Ser Leu Ser Glu Pro Gly Pro Gly Arg Ser 
                8725                8730                8735


Gly Arg Gly Phe Leu Phe Arg Val Leu Arg Ala Ala Leu Pro Leu Gln 
            8740                8745                8750


Leu Leu Leu Leu Leu Leu Ile Gly Leu Ala Cys Leu Val Pro Met Ser 
        8755                8760                8765


Glu Glu Asp Tyr Ser Cys Ala Leu Ser Asn Asn Phe Ala Arg Ser Phe 
    8770                8775                8780


His Pro Met Leu Arg Tyr Thr Asn Gly Pro Pro Pro Leu 
8785                8790                8795


<210>  3420
<211>  27674
<212>  DNA
<213>  Homo sapiens

<400>  3420
cccgggcagt ggaaaccgtg ggcaaaagtt agctggcagg acagcgcagc tcctccaggc     60

agcggaggca gcgcgtcccg gctctcaggg acatttcctt cccacctcga cccccgggag    120

gtggtcccgg tataaaggct cgctgagcgg gtgggtcaca gcacagcttt gcagctgcgg    180

agaaacgccc aaggccgtgc atctccagga gggcggctgg gctcccgcag tcctgcagac    240

cgcgcccgat cccggcgaca gggcgggcgg acagccgcgc atccccgggg tcccgccgag    300

cctgggcgca gagagccggg aggaagcgtt cgctcgcttc gccttgctgc tgggaaactg    360

aacgaggccg agagagaagg ttcttgagtt catgtaagag gacagtctta aaacggaaga    420

agaaaaagaa gcagttcagt ctttgggaga gctgcctcct tgttgagtgc tgcaaaggcc    480

tggaattcat ttatgacaga atagatctag aaaagtccaa gcatgttttc tagagtggtg    540

tagccctgtg ctgcctccag tgaagagtct cttggtgttg gcttcgtgct tccggaggga    600

ccatggcaac ctccagaggg gcctcccggt gtcctcggga tatcgccaat gtgatgcaga    660

ggctgcaaga tgagcaagag atagtacaaa aacgaacttt cacaaaatgg atcaactctc    720

atctggccaa gcggaaacct ccaatggtgg tggacgatct ttttgaagac atgaaagatg    780

gtgttaaact gcttgccctt ctggaggtcc tgtctgggca gaaactgcct tgtgaacaag    840

gacgccggat gaagcgaatc catgctgtgg ctaacattgg cacggcactc aagttcctcg    900

aaggaagaaa gattaaatta gtcaacatta actccaccga tatagctgat ggccgaccct    960

caatagttct tggattgatg tggaccatta ttctatattt ccagattgaa gagttgacca   1020

gcaacctgcc ccagctccag tctttgtcca gcagcgcatc ctccgtggac agcatagtta   1080

gctctgagac tcccagccca ccaagtaaac ggaaggtgac caccaagatc caaggaaatg   1140

ctaagaaggc tttattaaag tgggttcagt acacagctgg caagcagact ggaatagaag   1200

taaaagattt tgggaagagt tggagaagcg gggttgcctt tcattcagtt attcatgcca   1260

ttcgaccgga attggtggac ttggagacag tgaaaggcag atccaaccga gaaaatttgg   1320

aggatgcttt cactatcgcc gaaacagaac tggggatccc aagactgcta gatcctgaag   1380

acgttgatgt ggataaacca gatgagaaat ctattatgac ctatgtagcc cagtttctga   1440

aacattatcc tgacatccac aatgcaagca ctgatgggca agaggatgat gaaatacttc   1500

caggtttccc atcttttgca aattctgtac aaaattttaa gagagaagac agagtaattt   1560

ttaaggaaat gaaagtttgg atagaacaat ttgagagaga tttgacaaga gcacagatgg   1620

tggaatcaaa tttacaggat aaatatcagt catttaagca cttcagagtt caatatgaaa   1680

tgaagaggaa acagattgaa catttaatac aaccattaca cagagacggt aaattgtcac   1740

ttgaccaagc attggtaaaa caatcttggg atagagtgac ctccaggctc tttgactggc   1800

atatacagct tgataaatct cttcctgcac ctctgggcac cataggtgcc tggctgtaca   1860

gagcggaggt ggccctgaga gaggaaataa ccgttcaaca ggtccacgag gaaacagcaa   1920

acacgataca acggaaactt gagcaacata aggatctgct tcaaaacacg gatgcccaca   1980

aaagagcatt ccatgaaatc taccggacca ggtctgttaa cgggattcca gtgccacctg   2040

atcaattaga ggacatggcc gagaggtttc attttgtttc ctccacatca gagctacacc   2100

taatgaaaat ggaattttta gaattaaagt accgtctgct ctcactgctg gttcttgcag   2160

agtcaaagct gaagtcttgg atcattaagt acgggaggag agagtcagtg gagcagcttc   2220

tacaaaacta cgtgtctttt atagaaaata gcaagttctt tgaacaatat gaggtgacat   2280

accagatctt gaaacagaca gctgagatgt atgtcaaagc agatggttca gtggaagaag   2340

ctgagaatgt gatgaaattc atgaatgaaa ccaccgctca gtggaggaat ctctcagtag   2400

aagtgaggag tgtgaggagc atgctggaag aagtgatctc taactgggat cgctatggca   2460

atacagtggc tagtctgcaa gcctggctag aggatgctga aaaaatgctc aatcaatcag   2520

aaaatgccaa aaaggatttt tttcgaaatt tacctcattg gattcagcag catactgcca   2580

tgaacgatgc tggcaatttt ctaattgaaa cctgtgatga gatggtttcc cgtgacctga   2640

agcagcaatt actgttgcta aatgggcggt ggagggagtt gtttatggaa gtcaagcaat   2700

atgctcaagc tgatgagatg gacagaatga agaaggaata cacagactgt gttgttaccc   2760

tgtctgcttt tgcaacggaa gcccataaga aactttctga acccttagaa gtctctttta   2820

tgaatgtcaa gctattaatt caagacttgg aggatattga gcagagggtg cctgtgatgg   2880

atgcccaata caagataatt acaaagacag cacacctcat taccaaagaa agcccccaag   2940

aagaaggaaa agaaatgttt gcgaccatgt caaagctcaa agagcagcta accaaggtca   3000

aagaatgtta ctccccactc ctttatgagt ctcagcagct gttgattccg ttggaggaat   3060

tagaaaagca gatgacgtcc ttttatgact cacttgggaa aatcaatgaa attatcacag   3120

ttcttgagcg tgaggcacaa tcgagtgccc tttttaaaca aaaacatcag gaactgttag   3180

cttgtcaaga aaactgtaag aaaaccttga cacttattga gaaaggcagt caaagtgttc   3240

aaaagtttgt gaccttgagc aacgtgttaa agcattttga tcagacgagg ctacaaagac   3300

agattgcaga tattcatgtt gcttttcaga gtatggtaaa gaaaactgga gattggaaga   3360

agcatgtgga aaccaacagt cgcttgatga agaagtttga ggagtctcga gcagagttgg   3420

agaaggtact gcggattgct caggagggcc tggaggaaaa gggggatcca gaggagctcc   3480

tgcggagaca cactgagttt ttcagtcagc tggatcagag ggtgctcaat gctttcctga   3540

aagcttgtga tgaactcacc gacatccttc cagagcagga gcagcagggg ctgcaggaag   3600

ctgttcgaaa gctccacaaa caatggaagg atcttcaagg agaagcccct tatcatttgc   3660

ttcatctgaa gattgatgtg gagaagaata ggttcttagc ctctgtagaa gaatgcagaa   3720

ctgagctgga tcgagagacc aagctgatgc cccaggaagg cagtgaaaag ataattaaag   3780

agcacagggt tttcttcagt gacaaaggtc ctcatcatct ctgtgagaaa aggttacagc   3840

tcatcgagga actctgtgtg aaactcccag tgcgggaccc agtaagggac acacctggaa   3900

cctgtcacgt gactctcaaa gagctcagag ctgccattga cagcacctac aggaagctca   3960

tggaagaccc agacaagtgg aaggactaca ctagcagatt ctctgagttc tcatcttgga   4020

tatctacaaa tgagacacaa ttaaagggga tcaagggtga ggccatcgat actgccaacc   4080

acggagaggt taaacgtgcc gttgaagaga tcagaaatgg tgttaccaaa aggggtgaga   4140

ccctcagctg gctgaaatcc aggctgaaag ttttgacaga agtttcttct gagaatgaag   4200

cccaaaagca gggagatgag ctggcaaaat tatccagctc tttcaaggct cttgtgacgc   4260

tgctgtcaga ggttgaaaag atgctaagca attttgggga ctgtgtccag tacaaagaaa   4320

tagtcaaaaa ttctctcgaa gaattaattt ctggctctaa agaagtccag gaacaagctg   4380

agaagatctt ggatactgaa aatctgtttg aagcacagca gttacttctt catcaccagc   4440

aaaagacaaa gcggatctca gcaaagaaga gagatgtgca gcagcagatc gcgcaggcgc   4500

agcagggaga aggggggctg cctgaccgag gccacgagga gctgcggaag ctggagagca   4560

cactggatgg cctggagcgc agccgggaga ggcaggaacg ccgcatccag gtcacattaa   4620

gaaaatggga gcgatttgaa acaaacaaag aaacagtagt aagatacctt tttcaaacag   4680

gttccagtca tgaacgcttc ttgagtttta gcagtttgga aagtttatct tcagaactgg   4740

aacaaacaaa ggagttttct aaacggacag aaagtattgc agtccaggct gagaaccttg   4800

taaaggaagc ttcagagata ccgcttgggc cccaaaataa gcagctgctt caacagcagg   4860

ccaagtcaat caaagaacaa gtcaaaaaat tagaagacac gcttgaagaa gatattaaaa   4920

ccatggaaat ggtgaaaacc aagtgggatc attttggcag taattttgag actctgtccg   4980

tctggataac tgagaaagaa aaagaactca atgccttgga aacttcgtca tctgccatgg   5040

acatgcaaat cagccaaatt aaggtcacaa ttcaggaaat agaaagtaag ctcagcagca   5100

ttgtaggatt agaagaagaa gcccagtctt ttgctcagtt tgttaccact ggagaatctg   5160

ctcgaattaa agccaagttg acacaaataa gaagatacgg ggaagagctt cgagagcatg   5220

cacagtgtct ggaaggaaca atcctgggac atttatctca gcagcaaaag tttgaagaga   5280

accttagaaa gatccagcaa tctgtgtctg aatttgaaga taaacttgct gttccaatta   5340

aaatatgttc ttcagctaca gaaacataca aagttcttca agaacatatg gatctctgcc   5400

aggccctgga gtcactgagc agcgcgatca ctgccttctc agccagtgcc aggaaggttg   5460

tgaacagaga ttcctgtgtt caggaggctg cggctctaca gcagcaatac gaggacatcc   5520

taaggagggc gaaggagaga cagacggcgc tggagaatct gctggcccac tggcagaggc   5580

tagagaaaga actatcatcc tttttgacct ggttagagcg gggtgaagct aaagccagtt   5640

ccccagaaat ggacatttct gcagacagag tcaaagtgga aggtgaactt cagttaatac   5700

aggcactgca aaatgaagtt gtatcccagg cctcattcta tagcaaactt ttgcaattga   5760

aggaatcatt gttctcagta gcctccaaag atgatgtgaa aatgatgaaa ctacatttgg   5820

agcagttgga tgagagatgg agagatttac cacagatcat taacaaaagg attaattttc   5880

ttcagtctgt ggttgctgaa caccagcaat ttgatgagct gctgctttcc ttttctgtct   5940

ggattaaact gtttctcagt gaattacaaa ctacctctga gattagcata atggaccatc   6000

aagtagccct tactcggcat aaggaccacg cagcagaagt agagagcaaa aagggcgaat   6060

tgcagagtct gcagggtcac ttagcaaagt tgggttctct gggccgtgct gaggacctcc   6120

acctcctgca gggaaaggct gaggactgct tccagctgtt tgaggaggcc agccaggttg   6180

tggagaggcg gcagcttgcc ctgtcccatt tggcagaatt cctccagagc catgcctctc   6240

tgtccggcat tctccgccag ctgaggcaaa cagtggaagc aaccaacagt atgaataaga   6300

acgagtctga tttgatagaa aaggacctca atgatgctct tcaaaatgct aaagcattag   6360

aatctgctgc cgtcagtctg gatggcattc tttccaaagc ccaataccat ctgaaaatcg   6420

ggagctctga gcaaaggact tcctgcagag ccacggctga tcagctctgt ggagaggtag   6480

agaggatcca gaaccttctg ggaaccaagc agagtgaggc agatgctctg gcagtgttga   6540

aaaaagcatt ccaagaccag aaagaggagc ttctgaaaag cattgaggac attgaagaaa   6600

ggactgacaa agagcgattg aaagaaccta cccgccaagc tcttcagcag aggttaagag   6660

tgtttaatca gctagaagat gaattgaatt ctcacgagca tgaactatgt tggttgaaag   6720

acaaagccaa gcaaattgcc cagaaagatg tagcttttgc acctgaagtt gacagggaga   6780

taaaccgctt agaggtcacc tgggatgata ccaaaagact aattcatgaa aatcagggtc   6840

agtgctgtgg acttattgac ttaatgagag aatatcagaa cctgaaatca gctgtatcta   6900

aagtcttaga aaatgccagc agtgtgattg taaccagaac taccataaaa gatcaggagg   6960

atcttaaatg ggctttttcc aagcatgaaa ctgccaagaa caaaatgaat tacaaacaga   7020

aagacttgga taactttacc agcaaaggaa aacacttgtt atctgagctg aagaaaattc   7080

acagtagtga tttcagcttg gtgaaaacag acatggagag caccgtggac aaatggctgg   7140

atgtatcaga gaaacttgaa gaaaacatgg ataggctgag agtaagcctg tccatttggg   7200

atgatgtact gtcaactaga gatgagattg agggatggtc aaacaactgc gttccacaga   7260

tggcagaaaa catcagcaac ctggataacc acctcagagc tgaagaactg cttaaagaat   7320

ttgagtctga agttaaaaac aaagcattga gattggaaga actgcattcc aaagttaatg   7380

atctgaaaga attaactaaa aatctagaaa caccgccaga ccttcagttt atagaagcag   7440

acttaatgca gaaactggag catgccaaag aaataactga agtagcaaaa ggaaccctga   7500

aggatttcac ggctcaaagt acacaagtgg agaagtttat taatgacata acaacatggt   7560

tcacaaaagt ggaagaatcg ttgatgaact gtgcccaaaa tgagacttgt gaagcattga   7620

aaaaagtcaa ggatatacaa aaagaacttc aaagtcaaca aagcaacatc agctctaccc   7680

aagaaaatct caatagcttg tgccgcaagt accactcagc tgagttggag agcctgggcc   7740

gtgcaatgac tggtctgata aagaaacatg aagccgtgag ccagttgtgc tccaaaaccc   7800

aggccagcct gcaggaatct ctggaaaaac acttcagtga gtctatgcag gaattccaag   7860

aatggttttt gggagcaaag gcagcagcaa aagaatcatc agatcgcacc ggtgacagca   7920

aagttctaga agcaaagctc catgatcttc agaacatttt ggactcagtc agtgatgggc   7980

agagcaaact tgatgcagtg actcaagaag gacaaacttt gtatgcacat ttgtctaaac   8040

aaattgtcag tagcattcaa gaacaaatca caaaggccaa tgaagagttt caagcatttc   8100

tgaaacaatg ccttaaagat aagcaggctc ttcaagactg tgcttcagaa cttggaagct   8160

ttgaagatca gcacagaaaa ctgaacttat ggatccatga aatggaagaa aggttcaata   8220

cggaaaactt gggagagagt aaacagcaca ttcctgagaa gaaaaatgaa gttcataaag   8280

ttgaaatgtt tttgggagaa ctgctggctg caagagagtc tcttgataag ctttcccaga   8340

gagggcagct tctgagtgaa gaaggccacg gtgctgggca ggagggccgc ctgtgttccc   8400

agctcctcac aagccaccag aacctactta gaatgaccaa agagaaactc cggagctgcc   8460

aggtggccct tcaggagcac gaagccctgg aggaagcact gcaaagcatg tggttctggg   8520

tgaaggccat tcaggacaga ctggcctgtg cagagagcac tcttgggagc aaagacaccc   8580

tggagaaacg gctgtcacaa atacaggata ttctcctgat gaaaggtgaa ggggaagtta   8640

agttgaatat ggccattggc aagggggaac aggccttgag aagtagcaac aaagaaggtc   8700

agagggtgat tcagactcag ttagagaccc ttaaagaagt gtgggctgac atcatgagct   8760

cctccgtcca cgctcaaagc actttagagt ctgtgattag ccaatggaat gactatgtag   8820

agaggaaaaa ccagttggag cagtggatgg aatcagtgga tcaaaaaata gaacatccct   8880

tacaaccaca gccaggtctg aaagagaagt tcgtcctgct tgaccacctc cagtccatcc   8940

tgtctgaggc agaagatcac acgagagccc ttcaccgtct aattgcgaag tccagggagc   9000

tctacgaaaa gacagaggat gagtctttca aggacacagc tcaagaggag ctgaaaacac   9060

agtttaatga tataatgact gttgccaagg aaaaaatgag gaaagtggaa gagattgtga   9120

aagatcatct aatgtattta gatgcggtcc acgagttcac agattggctc cattcagcaa   9180

aggaagaact tcaccggtgg tcagatatgt ctggagattc atcagccacc cagaaaaagt   9240

tatcaaaaat taaggagctg atagattcca gagagattgg tgcaagccgt ctcagcagag   9300

tggagtcgct ggctcccgaa gtgaaacaga acacaactgc cagtgggtgt gagctcatgc   9360

acacggagat gcaggccctg cgtgccgact ggaagcagtg ggaagacagt gtattccaaa   9420

cgcagagctg tttggagaac ctggtcagcc agatggccct ttcggagcag gaattctcag   9480

gccaagtggc tcaactggag caggccctgg aacagttcag tgcccttctg aaaacctggg   9540

ctcagcagtt aaccctcctg gaaggcaaga acacggatga ggagatagtg gaatgctggc   9600

acaaaggaca agagatactg gatgctttgc aaaaagcaga gcctagaaca gaggatctca   9660

agtctcagct gaatgaactt tgtcgatttt ccagagacct gagtacctac agtggaaaag   9720

tttctggctt gattaaagag tataattgtc tttgtttgca agcatccaag ggctgccaga   9780

ataaagaaca gattttacag caaagatttc gaaaggcctt cagggatttc cagcagtggt   9840

tggttaatgc aaaaatcact accgccaagt gttttgatat acctcaaaat ataagtgaag   9900

tttcaactag tcttcagaaa atacaggagt ttttgtcaga aagtgaaaat ggacagcaca   9960

agctaaacat gatgctgtct aaaggggaac ttctgagtac cctgctgacc aaagagaaag  10020

cgaaagggat ccaggccaaa gttacagctg caaaagaaga ttggaaaaat tttcattcaa  10080

atctccacca aaaagaatct gctctagaga atctaaagat ccaaatgaag gactttgaag  10140

taagtgctga gcctatccag gactggctga gtaaaactga gaagatggtc catgaaagca  10200

gcaatcgcct ctatgatctg ccagcaaaga ggagggagca gcagaagctc cagtctgtcc  10260

ttgaggaaat acactgctac gagcctcagc tcaacaggct gaaagagaaa gctcagcagc  10320

tgtgggaagg acaagctgcc agcaagagct ttaggcacag agtgtcgcag ctgtcttctc  10380

agtatctagc gctaagcaat ttaacaaagg agaaagtgtc aagactggat agaatcgttg  10440

cagaacacaa tcagttctct cttgggatta aagaattaca agactggatg acggatgcga  10500

ttcacatgct ggattcatac tgccacccga catccgacaa aagtgtgctg gacagcagga  10560

cgctcaagct cgaggctcta ttatcagtca aacaggaaaa agagattcag atgaaaatga  10620

tagtgaccag gggagaatct gtccttcaga atacttctcc agaaggcatt cccactattc  10680

agcagcagct gcagagtgtg aaggatatgt gggcatccct tttgtctgca gggattcgtt  10740

gtaaaagcca actcgaagga gctctctcca agtggacaag ttatcaggat ggcgttcgac  10800

agttctccgg ttggatggat agtatggaag ccaacctgaa tgaatcagaa aggcagcatg  10860

cggagctgcg ggataaaaca acgatgctcg gaaaagccaa gttattaaat gaagaagtgc  10920

tgagttacag cagcttgctg gagaccatcg aagtcaaagg ggctggcatg acagaacact  10980

atgtcaccca gctagaactc caggatctac aggaacgata cagagccatc caagagaggg  11040

ccaaggaagc cgtaaccaag tctgaaaaac ttgtccgcct gcaccaagag tatcagagag  11100

acctaaaggc atttgaagtt tggttggggc aagaacaaga aaagctcgac cagtattcag  11160

ttcttgaagg tgatgcccac actcatgaga caacattgcg tgatcttcag gagctacagg  11220

tacactgtgc agaggggcag gccctgttga actcagtgct gcacaccaga gaggatgtga  11280

tcccatcagg tatcccacag gcagaggacc gggctttaga gtctctccgg caagactggc  11340

aggcttacca gcacaggctg tccgagactc gaactcagtt caataacgtg gtgaacaaat  11400

tgaggctaat ggagcaaaag tttcagcaag tagatgaatg gctcaaaaca gcagaggaga  11460

aagttagtcc caggaccaga cgtcagtcta acagggcaac caaggagata caattacatc  11520

agatgaagaa gtggcacgaa gaagtgactg catacagaga tgaagttgag gaagtgggag  11580

ctagagctca ggagatactg gacgagagcc acgtgaacag cagaatgggt tgccaggcca  11640

cccagctgac ttccagatac caggccctgc ttctccaagt gctggaacaa ataaaattcc  11700

tggaggagga gattcagagt ttggaggaat cagaatcatc cctcagttcc tattctgatt  11760

ggtatggctc tactcataaa aacttcaaga atgtggctac caagattgac aaagtagata  11820

cagtaatgat ggggaagaaa ttgaagacgt tggaggtttt gctcaaagac atggagaaag  11880

gtcacagttt gctgaaatca gcccgggaga aaggagagag ggctgttaaa tacttggagg  11940

aaggcgaggc agagaggtta agaaaggaga ttcatgatca catggagcag ttgaaggaac  12000

tgaccagcac tgtccggaaa gaacacatga cgctggaaaa aggtcttcat ttagcaaagg  12060

aattctcaga taaatgcaaa gcactgacac agtggatagc agaataccag gaaattctac  12120

atgttcctga agaacccaaa atggaattat atgagaaaaa agctcagtta tctaaataca  12180

agtcacttca acaaacggtg ctgtcccatg aaccatcagt aaagtcagtg agagagaagg  12240

gtgaagctct tttggaactg gtgcaggacg tcactttaaa ggacaaaata gatcaacttc  12300

aaagtgatta ccaggacctg tgcagcatag gaaaggagca tgtcttcagt ctggaggcga  12360

aagtcaaaga ccatgaagac tacaacagtg agctccaaga ggtcgaaaag tggctgctgc  12420

agatgtctgg cagactggtg gcacctgacc tcctggagac aagcagcctg gagacaatca  12480

cccagcaatt ggcccaccac aaggcaatga tggaagaaat tgctggtttt gaagaccgtt  12540

tgaacaatct tcaaatgaaa ggtgatactt tgattggcca atgtgcagac cacctgcaag  12600

cgaaacttaa acaaaacgtg catgctcatc tgcagggcac aaaggacagc tactcagcga  12660

tctgcagcac agctcagagg atgtaccaga gtttggaaca cgaacttcag aagcacgtca  12720

gccgacaaga caccctgcag cagtgccagg cctggctttc tgcagtccag ccggatttag  12780

agccaagtcc tcaaccacct cttagtaggg cagaagccat taagcaggtc aaacacttca  12840

gagctttgca agagcaggca aggacctacc tagatctcct ttgctccatg tgtgacctgt  12900

caaatgcttc ggtgaaaacc acagcaaaag acattcaaca aacagagcaa acgattgaac  12960

aaaagcttgt ccaggcccag aacttaactc agggctggga agagatcaag cacctgaagt  13020

ctgagctctg gatttacctg caagatgctg atcagcaact gcagaacatg aagaggaggc  13080

actctgagct ggagctgaac attgcacaga acatggtttc acaagttaag gattttgtta  13140

agaaactaca gagcaaacag gcatccgtga acaccataat agaaaaggtg aataagttaa  13200

caaagaagga ggaatcgcct gaacacaagg aaataaatca tttaaatgat cagtggctcg  13260

atttgtgccg tcagtctaac aacctgtgct tgcaaaggga agaggatctt cagagaacaa  13320

gagattacca tgactgtatg aatgttgttg aagtgttcct agaaaaattt actacagaat  13380

gggataactt ggccagatct gatgcagaga gtacagctgt ccacctggaa gctttgaaaa  13440

agttagcatt ggcattgcag gagagaaagt atgctattga agatctgaaa gatcaaaagc  13500

agaaaatgat agagcatctg aatttagatg acaaggagtt agtcaaagaa cagacgagtc  13560

atttagagca acgttggttt cagcttgagg acctcattaa aaggaaaatc caagtgtcag  13620

tcaccaactt ggaggagtta aatgtggtgc agtccagatt tcaggagcta atggagtggg  13680

cagaagagca acaacccaac atcgccgagg cccttaagca gagccctcct ccagatatgg  13740

ctcagaacct tctcatggat cacctggcca tctgcagtga actggaggcc aagcagatgc  13800

tcctgaaatc gcttataaag gacgcagaca gggtcatggc agatcttggt ctcaatgagc  13860

gacaggtcat ccagaaggct ctctctgatg cacaaagcca cgtgaattgt ctcagtgact  13920

tagtgggcca gcgaagaaag tacttaaaca aagccttgtc cgagaaaacc cagtttctca  13980

tggcagtgtt ccaggccacc agccaaattc agcaacatga gcgaaagata atgttccgtg  14040

aacacatctg tctgttacca gatgatgtga gcaaacaagt caaaacatgt aagagtgcac  14100

aagccagcct caagacttac caaaatgaag tcactggact ttgggcccag ggtcgcgaac  14160

taatgaagga agtcacagag caggaaaaga gtgaagtgct ggggaagctt caggaattgc  14220

agagtgtcta tgacagtgtt ttacaaaagt gcagtcaccg gttacaagaa ctagagaaga  14280

atttggtttc taggaagcat tttaaggaag attttgataa agcttgccac tggctaaaac  14340

aagcagatat tgttacattt cctgaaatca acctaatgaa tgagagttct gagcttcata  14400

cacaactggc taaataccaa aacattcttg aacaatctcc agaatatgaa aatcttctac  14460

ttacgctgca gagaactggg cagaccatat taccatcgct gaatgaagtc gatcattcct  14520

acctcagtga aaagctaaat gctttgcctc gacaatttaa tgtaattgtt gccttggcta  14580

aagacaagtt ctataaagtc caggaagcaa ttcttgctcg gaaggaatat gcttccttga  14640

ttgagttgac aacccagtct ctgagtgaac ttgaagccca attcttgagg atgagcaaag  14700

ttcccaccga cctggccgtt gaggaggctc tttctctgca agatggttgc agagccattc  14760

tggacgaggt ggcgggcctt ggggaggcgg tggatgaact gaaccagaaa aaagaaggtt  14820

ttcgcagcac aggtcagcct tggcagccag acaagatgct gcaccttgtc accttatatc  14880

acaggctgaa gcgacaaaca gaacagaggg ttagcttatt agaagacacc accagtgctt  14940

accaagaaca cgagaagatg tgccaacagc tggagagaca actgaagtct gtaaaagagg  15000

agcagtccaa agtgaatgag gaaacgctgc ctgcagagga gaagctcaaa atgtatcact  15060

ccctggcagg aagtctccag gactcaggga ttgtactgaa acgagtaacc atacatcttg  15120

aagatcttgc cccacacctt gaccccttgg cttatgagaa agccaggcat cagatccagt  15180

cctggcaagg ggagttaaaa ctgttgactt ctgccattgg tgagacggtg acagaatgtg  15240

agagccgaat ggtgcagagt atagacttcc agactgagat gagtcgctcc ctggactggc  15300

tgaggagagt gaaggcagag ctcagtgggc cggtgtacct agacctcaac ctgcaggaca  15360

tccaagagga aatcagaaaa atccaaattc atcaggaaga ggtccagtcc agcttgagaa  15420

tcatgaatgc gctgagtcac aaggaaaagg agaagttcac aaaggccaag gagctgattt  15480

ctgcggattt agaacacagc ctcgctgagc tctcagagct ggatggagac atccaggaag  15540

ccttacgcac cagacaggct accttgactg aaatatatag ccagtgtcaa aggtattatc  15600

aggtatttca agcagccaat gactggcttg aggatgccca agaattgtta cagctggcag  15660

gcaatggcct agacgtggag agcgcagagg aaaatctcaa aagccacatg gaatttttca  15720

gtacagagga tcagttccat agtaacctgg aggagctcca cagcctggta gccaccctgg  15780

acccactcat caagccaacc ggcaaagaag acctagaaca gaaagtggct tctctggaac  15840

tcaggagcca gaggatgagc cgggactctg gtgcccaagt ggatctcttg cagagatgca  15900

cagctcaatg gcacgattac cagaaagcaa gggaagaggt tattgaattg atgaatgata  15960

cagaaaagaa attgtctgag ttttctttgt tgaagacttc gtctagtcat gaagcggaag  16020

aaaaattgtc agaacacaag gctttagtgt cagtggttaa ctctttccat gagaaaattg  16080

tggcccttga ggaaaaagct tcacaactgg agaaaaccgg aaatgatgcc agcaaagcca  16140

ccctgagcag gtcaatgacc accgtctggc agcgctggac acgccttcga gctgtggccc  16200

aggaccagga gaagatcctg gaagatgcag tggatgagtg gacgggcttt aacaacaagg  16260

ttaaaaaggc cactgaaatg attgatcagc tgcaagataa gttacctgga agttcagcag  16320

agaaagcatc gaaagcagag ctcttaactc ttcttgaata ccacgacacg ttcgttctgg  16380

agctggagca gcagcagtcg gccttgggca tgctgcggca gcaaaccctg agcatgctcc  16440

aggatggagc cgccccaacc cctggggaag agcctccgct catgcaggaa atcaccgcca  16500

tgcaagatcg gtgcctgaac atgcaggaga aagtgaagac taatggaaag ttggtgaagc  16560

aagagctgaa ggaccgagaa atggtggaga ctcagatcaa ttctgtgaaa tgttgggttc  16620

aggaaacgaa agaatattta gggaatccaa caatagaaat agatgctcaa cttgaagaac  16680

ttcagattct cctaacagaa gccacaaatc accgacagaa cattgaaaaa atggcagaag  16740

aacagaagga gaagtactta ggtctttata ccatattacc ttctgaactc tcccttcagt  16800

tggctgaagt ggcgttagat ctaaagatcc gagatcagat ccaagacaaa ataaaagaag  16860

ttgagcagag caaggccacg agccaggaac tcagccggca aattcagaag ttagctaaag  16920

acctcacaac tattctaact aagctgaaag cgaagacaga taatgtagtt caagctaaaa  16980

ctgaccaaaa ggtgctggga gaggaattag atggctgtaa ttcaaagtta atggaattag  17040

atgcagcagt acagaaattc ttggaacaga atggccaact gggtaagcca ctggccaaga  17100

agataggaaa actgactgaa cttcaccagc agaccattag acaagctgag aatcggctct  17160

ccaagctcaa tcaggcagca tcacatttag aagaatacaa tgaaatgctt gaattaattt  17220

tgaagtggat tgaaaaagct aaagtcttgg ctcatggaac tattgcatgg aattctgcaa  17280

gccagcttcg ggaacaatat attttgcatc agaccctgct agaagaatcc aaagaaattg  17340

acagtgagct ggaagcaatg actgagaaat tacagtacct cactagcgtg tactgtacag  17400

aaaaaatgtc tcagcaagtg gcagaactgg gacgggagac tgaggagttg cgacagatga  17460

tcaaaattcg tttgcagaac ctccaagatg cagctaagga tatgaaaaaa tttgaagcag  17520

agttgaaaaa gttacaagct gccttggagc aagcccaggc aacactgact tctccagaag  17580

ttggacgtct cagtctcaag gagcagctct ctcatcggca gcatttgttg tctgagatgg  17640

agtcactgaa gccgaaggtg caagcagtgc agctctgcca gagtgccctc cggatccccg  17700

aggatgtggt tgccagctta cctctctgtc atgctgctct gcggctgcag gaagaggcca  17760

gccggctgca gcacaccgcc atccagcagt gtaacatcat gcaggcagct gtggtacaat  17820

atgaacaata tgagcaagaa atgaaacatc tccagcaact gatagaagga gctcacagag  17880

agattgagga taaacctgtt gccaccagta acatacagga gctgcaggct cagatttctc  17940

ggcatgagga gctggcgcag aaaattaagg gctaccagga gcagatcgct tctttgaatt  18000

ccaagtgcaa gatgctgacg atgaaagcca agcacgccac catgctgctg acggtgaccg  18060

aggtcgaggg gctggcggaa gggacagagg acctggatgg ggagctcctc cccacgcctt  18120

cggcccaccc ctctgtggtc atgatgactg caggtcgctg tcacactttg ctgtcaccgg  18180

tcactgagga gtctggggag gagggaacca acagtgagat ttcctctcca cctgcctgtc  18240

gctccccttc acctgtggct aatacagatg cttctgttaa ccaggacatt gcatattacc  18300

aagccttgtc tgctgagagg ttgcagacag atgctgcaaa aattcacccc agcacatccg  18360

catcccagga gttctatgaa ccgggattgg agccatccgc tactgccaaa ctgggtgatt  18420

tgcagcgttc ttgggaaacc ttaaagaatg tgatcagtga gaagcagcgc acactctatg  18480

aagctttgga acgccagcag aagtaccagg actccctcca gtccatctct acgaagatgg  18540

aggccattga gctgaaactc agtgagagcc cagagcctgg caggagtcca gaaagccaga  18600

tggctgaaca tcaggcattg atggatgaga ttctcatgct ccaggatgaa atcaatgagc  18660

tccagtcctc tctcgcagag gagctggtat ccgagtcttg tgaggccgac cctgcggagc  18720

agctggcctt gcagtccacg ctcactgtct tagccgagcg aatgtccacc atcaggatga  18780

aagcctcggg gaaacggcag cttttggagg agaagttgaa tgatcagctg gaggaacaaa  18840

ggcaggaaca ggccctgcag aggtatcgct gtgaagccga tgagctggac agctggctct  18900

tgagtaccaa ggccactctg gacactgcgc tgagtccacc caaggagccc atggacatgg  18960

aggcccagct tatggactgc cagaatatgc tggtggaaat agagcagaag gtggtggctt  19020

tatcagaact gtcagtccac aatgagaacc tgctgctgga gggcaaagct cacaccaagg  19080

acgaggccga gcagctggct ggaaagctga gaaggctcaa ggggagcctg ctggagctgc  19140

agagagccct gcatgataag cagctcaaca tgcagggaac agcacaggag aaggaggaga  19200

gcgatgttga cctaacagcc acgcagagcc ccggcgtcca ggaatggctg gcccaagctc  19260

gcaccacatg gacccagcag cggcagagca gtctccagca acaaaaagag ttagaacagg  19320

aattagccga gcagaagagt ctccttcgct cagtagccag tcgtggagag gagattctaa  19380

ttcaacattc ggcggcagag acctctggtg atgctggcga aaaacctgat gtgttatccc  19440

aggagttggg gatggaaggg gagaaatcat ccgctgaaga ccagatgaga atgaaatggg  19500

aaagcctaca tcaagaattt agtaccaagc agaaactact acagaatgtt ctggaacagg  19560

aacaagagca agtgctttat agcaggccaa atcgactctt gtctggtgtg ccactgtaca  19620

aaggggacgt gccaacccaa gataaatctg cagttacatc tttgctggat ggactgaacc  19680

aagccttcga ggaggtttca tcccagagtg gaggggcaaa gaggcagagt atacacttgg  19740

agcagaagtt gtatgatgga gtctcagcca cctctacttg gttggatgac gttgaagaac  19800

gtttatttgt tgccacagca cttttaccag aagaaacaga gacttgtctc ttcaaccaag  19860

agattcttgc caaagacatt aaggaaatgt ctgaagaaat ggataagaac aaaaacttgt  19920

tttcccaagc ttttccagag aatggtgata atcgagatgt tattgaagat actttgggtt  19980

gtcttttggg caggttatcc ttgctagact cagtagtgaa tcaacgatgt catcagatga  20040

aagaaagact tcagcaaata ctaaatttcc agaatgatct gaaagtgctg tttacatcac  20100

tggctgacaa caaatacatc attctgcaaa aactggcaaa tgtgtttgaa cagcccgtag  20160

cagaacaaat agaggcaata caacaggctg aagatggact caaagaattt gatgcaggaa  20220

tcattgaatt aaagaggcgt ggtgacaagc tacaggtcga gcagccgtcc atgcaagaac  20280

tctccaagct ccaggacatg tatgatgagc tgatgatgat cattggctcc cggaggagtg  20340

gtctgaatca gaaccttaca ctcaagagtc agtatgagag ggccctacaa gatctggctg  20400

acctgctaga aactggtcag gagaagatgg caggagacca gaaaatcatc gtgtcttcca  20460

aagaggaaat ccagcaacta cttgacaaac ataaggaata ctttcagggc ctggaatctc  20520

atatgatctt gactgaaaca ctcttcagaa agataatcag ctttgcagtc caaaaggaaa  20580

cccagttcca tacagagctg atggctcagg cttctgctgt actgaaacgg gctcacaaga  20640

ggggtgtgga gctggagtac attctagaga cgtggtccca tctggatgag gaccagcagg  20700

agctcagcag acagctggag gtggtggaaa gcagcatccc aagcgtgggt ctggtggagg  20760

agaacgagga caggcttatt gaccgcataa cactctacca gcatttaaaa tctagcctta  20820

atgaatacca gcccaaatta tatcaagtat tagatgatgg gaaacgactt ctgatatcca  20880

tcagctgctc agatctagaa agccaactaa atcaacttgg agagtgctgg ctaagtaaca  20940

ccaataaaat gtctaaggaa cttcacagac tggaaacaat attgaaacac tggaccagat  21000

atcaaagtga atctgcagat ctaattcact ggttacaatc tgcaaaagac cggctagaat  21060

tttggactca gcaatctgtg acagtcccac aagagctgga aatggtccgt gatcatctaa  21120

atgctttcct ggagttttct aaagaagtgg atgcccaatc ttccctgaaa tcatctgttc  21180

tgagtactgg aaatcagctc cttcgactaa aaaaggtgga cacagccacg ctgcgctctg  21240

agctgtcgcg cattgatagc cagtggactg acctgctaac caatatccca gccgtccagg  21300

agaagctcca ccagctccag atggataaac tgccttcccg ccatgccatt tctgaagtca  21360

tgagttggat ttctctaatg gaaaatgtta ttcagaagga tgaagataat attaaaaatt  21420

ccataggtta caaggcaatt catgaatacc ttcagaaata taagggtttt aagatagaca  21480

ttaactgtaa acagctgaca gtggattttg tgaaccagtc cgtgctacaa atcagcagtc  21540

aggatgtgga aagtaagcgt agtgataaga ctgattttgc tgagcaactt ggagcaatga  21600

ataaaagttg gcaaattctg caaggtctag taactgagaa gatccagctg ttggaaggct  21660

tattggaatc ttggtcagaa tatgaaaata atgtacaatg tctgaaaaca tggtttgaaa  21720

cccaggaaaa gagactaaaa caacagcatc gaattggaga tcaggcttct gttcaaaatg  21780

cactgaaaga ctgtcaggat ctggaagatt tgattaaagc aaaagaaaaa gaagtagaga  21840

aaattgagca gaatggactt gctttgattc agaacaagaa agaagacgtc tctagcattg  21900

tcatgagcac actgcgagag ctcggccaaa cctgggcaaa tttagatcac atggttggac  21960

aattaaagat actgctgaaa tcagtgcttg accaatggag tagtcacaaa gtggcctttg  22020

acaagataaa cagttacctc atggaggcca gatactctct ttcccgattc cgtctgctga  22080

ctggctcctt agaagctgtg caagttcagg tggacaatct tcagaatctc caagatgatc  22140

tggaaaaaca ggaaaggagc ttacagaaat ttggctctat caccaaccaa ttattaaaag  22200

agtgtcaccc acccgtgaca gaaactctta ccaatacact gaaagaagtc aacatgagat  22260

ggaataactt gctggaagag attgctgagc agctacagtc cagcaaggcc ctacttcagc  22320

tttggcaaag atacaaggac tactccaaac agtgtgcttc gacagttcag cagcaggagg  22380

atcgaaccaa tgagctgttg aaggcagcca caaacaagga cattgccgat gatgaggttg  22440

ccacatggat tcaagattgc aacgacctcc tcaaaggact gggcacagtt aaagattccc  22500

tcttttttct ccatgagctg ggagagcaac tgaagcaaca agtggatgct tccgcagcat  22560

cagctattca atcggatcaa ctctctttga gtcaacactt gtgtgccctg gagcaagctc  22620

tctgcaaaca gcagacttca ttacaggctg gagttcttga ttatgaaacc tttgccaaga  22680

gtttagaagc tttggaggcc tggatagtgg aagctgaaga aatactacaa gggcaggacc  22740

ctagccactc atctgacctc tccacaatcc aggaaaggat ggaagaactt aagggacaga  22800

tgttaaaatt cagcagcatg gctccagatt tagaccgtct aaatgagctt ggatataggt  22860

tacccttgaa tgataaggaa atcaaaagaa tgcagaatct gaaccgccat tggtctctga  22920

tctcctctca gactacagaa agattcagca agttgcagtc atttttgcta caacatcaga  22980

ctttcttgga aaaatgtgaa acatggatgg aattcctagt tcagacagaa caaaagttag  23040

cagtagagat ttcaggaaat tatcagcacc ttttggaaca gcagagagca cacgagttgt  23100

ttcaagccga gatgttcagt cgtcagcaga ttttgcactc aatcattatt gatgggcaac  23160

gtcttctaga acaaggtcaa gttgatgaca gggatgaatt caacctgaaa ttgacactcc  23220

tcagtaatca atggcaggga gtgattcgca gggcccagca gaggcggggg atcattgaca  23280

gccagattcg ccagtggcag cgctataggg agatggcaga aaagcttcgt aaatggttgg  23340

ttgaagtgtc ctacctcccc atgagtggtc tcggaagtgt tcctatacca ctgcaacaag  23400

caaggaccct ctttgatgaa gtgcagttca aagaaaaagt gtttctgcgg caacaaggca  23460

gctacatcct gactgtggag gctggcaagc aactccttct ctcggcggac agtggcgctg  23520

aggccgcctt gcaggccgaa ctcgctgaaa tccaagagaa atggaaatca gccagcatgc  23580

ggctggaaga acagaagaaa aaactagcct tcttgttgaa agactgggaa aaatgtgaga  23640

aaggaatagc agattccctg gagaaactac gaactttcaa aaagaagctt tcgcagtctc  23700

tcccggatca ccatgaagag ctccatgcag aacaaatgcg ttgcaaggaa ttagaaaatg  23760

cagttgggag ctggacagat gacttgaccc agttgagcct gctgaaggac accctctctg  23820

cctatatcag tgctgatgat atctccattc ttaatgaacg cgtagagctt ctgcaaaggc  23880

agtgggaaga actatgccac cagctctcct taaggcggca gcaaataggt gaaagattga  23940

atgaatgggc agtcttcagt gaaaagaaca aggaactctg tgagtggttg actcaaatgg  24000

aaagcaaagt ttctcagaat ggagacattc tcattgaaga aatgatagag aagctcaaga  24060

aggattatca agaggaaatt gctattgctc aagagaacaa aatacagctc caacaaatgg  24120

gagaacgact tgctaaagcc agccatgaaa gcaaagcatc tgagattgaa tacaagctgg  24180

gaaaggtcaa cgaccggtgg cagcatctcc tggacctcat tgcagccagg gtgaagaagc  24240

tgaaggagac cctggtagcc gtgcagcagc ttgataagaa catgagcagc ctgaggacct  24300

ggctcgctca catcgagtca gagctggcca agccaatagt ctacgattcc tgtaactcgg  24360

aagaaataca gagaaagctt aatgagcagc aggagcttca gagagacata gagaagcaca  24420

gtacaggtgt tgcatctgtc ctcaacctgt gtgaagtcct gctgcacgac tgtgacgcct  24480

gtgccactga tgccgagtgt gactctatac agcaggctac gagaaacctg gaccggcggt  24540

ggagaaacat ttgtgctatg tccatggaaa ggaggctgaa aatcgaagag acgtggcgat  24600

tgtggcagaa atttctggat gactattcac gttttgaaga ttggctgaag tcttcagaaa  24660

ggacagctgc ttttcccagc tcttctgggg tgatctatac agttgccaag gaagaactaa  24720

agaaatttga ggctttccag cgacaggtcc acgagtgcct gacgcagctg gaactgatca  24780

acaagcagta ccgccgcctg gccagggaga accgcactga ttcagcatgt agcctcaaac  24840

agatggttca cgaaggcaac cagagatggg acaacctgca aaagcgtgtc acctccatct  24900

tgcgcagact caagcatttt attggccagc gtgaggagtt tgagactgcg cgggacagca  24960

ttctggtctg gctcacagag atggatctgc agctcactaa tattgaacat ttttctgagt  25020

gtgatgttca agctaaaata aagcaactca aggccttcca gcaggaaatt tcactgaacc  25080

acaataagat tgagcagata attgcccaag gagaacagct gatagaaaag agtgagccct  25140

tggatgcagc gatcatcgag gaggaactag atgagctccg acggtactgc caggaggtct  25200

tcgggcgtgt ggaaagatac cataagaaac tgatccgcct gcctctccca gacgatgagc  25260

acgacctctc agacagggag ctggagctgg aagactctgc agctctgtcg gacctgcact  25320

ggcacgaccg ctctgcagac agcctgcttt ctccacagcc ttcctccaat ctctccctct  25380

cgctcgctca gcccctccgg agcgagcggt caggacgaga caccccggct agtgtggact  25440

ccatccccct ggagtgggat cacgactatg acctcagtcg ggacctggag tctgcaatgt  25500

ccagagctct gccctctgag gatgaagaag gtcaggatga caaagatttc tacctccggg  25560

gagctgttgg cttatcaggg gaccacagtg ccctagagtc acagatccga caactgggca  25620

aagccctgga tgatagccgt tttcagatac agcaaaccga aaatatcatt cgcagcaaaa  25680

ctcccacggg gccggagcta gacaccagct acaaaggcta catgaaactg ctgggcgaat  25740

gcagtagcag tatagactcc gtgaagagac tggagcacaa actgaaggag gaagaggaga  25800

gccttcctgg ctttgttaac ctgcatagta ccgaaaccca aacggctggt gtgattgacc  25860

gatgggagct tctccaggcc caggcattga gcaaggagtt gaggatgaag cagaacctcc  25920

agaagtggca gcagtttaac tcagacttga acagcatctg ggcctggctg ggggacacgg  25980

aggaggagtt ggaacagctc cagcgtctgg aactcagcac tgacatccag accatcgagc  26040

tccagatcaa aaagctcaag gagctccaga aagctgtgga ccaccgcaaa gccatcatcc  26100

tctccatcaa tctctgcagc cctgagttca cccaggctga cagcaaggag agccgggacc  26160

tgcaggatcg cttgtcgcag atgaatgggc gctgggaccg agtgtgctct ctgctggagg  26220

agtggcgggg cctgctgcag gatgccctga tgcagtgcca gggtttccat gaaatgagcc  26280

atggtttgct tcttatgctg gagaacattg acagaaggaa aaatgaaatt gtccctattg  26340

attctaacct tgatgcagag atacttcagg accatcacaa acagcttatg caaataaagc  26400

atgagctgtt ggaatcccaa ctcagagtag cctctttgca agacatgtct tgccaactac  26460

tggtgaatgc tgaaggaaca gactgtttag aagccaaaga aaaagtccat gttattggaa  26520

atcggctcaa acttctcttg aaggaggtca gtcgtcatat caaggaactg gagaagttat  26580

tagacgtgtc aagtagtcag caggatttgt cttcctggtc ttctgctgat gaactggaca  26640

cctcagggtc tgtgagtccc acatcaggaa ggagcacccc aaacagacag aaaacgccac  26700

gaggcaagtg tagtctctca cagcctggac cctctgtcag cagtccacat agcaggtcca  26760

caaaaggtgg ctccgattcc tccctttctg agccagggcc aggtcggtcc ggccgcggct  26820

tcctgttcag agtcctccga gcagctcttc cccttcagct tctcctgctc ctcctcatcg  26880

ggcttgcctg ccttgtacca atgtcagagg aagactacag ctgtgccctc tccaacaact  26940

ttgcccggtc attccacccc atgctcagat acacgaatgg ccctcctcca ctctgaacta  27000

agcagatgcc atctgcagaa gtgctggtag cataaggagg atcgggtcat aagcaatccc  27060

aaactaccaa caagaggacc ttgatcttgg cgaaagccct cggtgtggca gctttagccc  27120

tcctccagat cacatgtgtg caaattatgg cttcagaggt ggaagataaa cagtgacggg  27180

ggaacaaaca gacaacaaga aggtttggaa gaaatctggt ttgagactct gaaccttagc  27240

actaaggaga ttgagtaagg acctccaaag ttccccggac tcatgaattc tgggcccttg  27300

gcccattctg tgcacagcca aggacttcag tagaccatct gggcagcttt cccatggtgc  27360

tgctccaacc atcagataaa tgaccctccc aagcaccatg tcagtgtcgt acaatctacc  27420

aaccaaccag tgctgaagag attttagaac cttgtaacat acaattttta agagcttata  27480

tggcagcttc ctttttacct tgttttcctt tggggcatga tgttttaacc tttgctttag  27540

aagcacaagc tgtaaatcta aaaggcactt ttttttagag gtataaagaa aaactagatg  27600

taataaataa gatcatggaa ggctttatgt gaaaaaagtt gaatgttata gtaaaaaaaa  27660

aaagatattt atgt                                                    27674


<210>  3421
<211>  8797
<212>  PRT
<213>  Homo sapiens

<400>  3421

Met Ala Thr Ser Arg Gly Ala Ser Arg Cys Pro Arg Asp Ile Ala Asn 
1               5                   10                  15


Val Met Gln Arg Leu Gln Asp Glu Gln Glu Ile Val Gln Lys Arg Thr 
            20                  25                  30


Phe Thr Lys Trp Ile Asn Ser His Leu Ala Lys Arg Lys Pro Pro Met 
        35                  40                  45


Val Val Asp Asp Leu Phe Glu Asp Met Lys Asp Gly Val Lys Leu Leu 
    50                  55                  60


Ala Leu Leu Glu Val Leu Ser Gly Gln Lys Leu Pro Cys Glu Gln Gly 
65                  70                  75                  80


Arg Arg Met Lys Arg Ile His Ala Val Ala Asn Ile Gly Thr Ala Leu 
                85                  90                  95


Lys Phe Leu Glu Gly Arg Lys Ile Lys Leu Val Asn Ile Asn Ser Thr 
            100                 105                 110


Asp Ile Ala Asp Gly Arg Pro Ser Ile Val Leu Gly Leu Met Trp Thr 
        115                 120                 125


Ile Ile Leu Tyr Phe Gln Ile Glu Glu Leu Thr Ser Asn Leu Pro Gln 
    130                 135                 140


Leu Gln Ser Leu Ser Ser Ser Ala Ser Ser Val Asp Ser Ile Val Ser 
145                 150                 155                 160


Ser Glu Thr Pro Ser Pro Pro Ser Lys Arg Lys Val Thr Thr Lys Ile 
                165                 170                 175


Gln Gly Asn Ala Lys Lys Ala Leu Leu Lys Trp Val Gln Tyr Thr Ala 
            180                 185                 190


Gly Lys Gln Thr Gly Ile Glu Val Lys Asp Phe Gly Lys Ser Trp Arg 
        195                 200                 205


Ser Gly Val Ala Phe His Ser Val Ile His Ala Ile Arg Pro Glu Leu 
    210                 215                 220


Val Asp Leu Glu Thr Val Lys Gly Arg Ser Asn Arg Glu Asn Leu Glu 
225                 230                 235                 240


Asp Ala Phe Thr Ile Ala Glu Thr Glu Leu Gly Ile Pro Arg Leu Leu 
                245                 250                 255


Asp Pro Glu Asp Val Asp Val Asp Lys Pro Asp Glu Lys Ser Ile Met 
            260                 265                 270


Thr Tyr Val Ala Gln Phe Leu Lys His Tyr Pro Asp Ile His Asn Ala 
        275                 280                 285


Ser Thr Asp Gly Gln Glu Asp Asp Glu Ile Leu Pro Gly Phe Pro Ser 
    290                 295                 300


Phe Ala Asn Ser Val Gln Asn Phe Lys Arg Glu Asp Arg Val Ile Phe 
305                 310                 315                 320


Lys Glu Met Lys Val Trp Ile Glu Gln Phe Glu Arg Asp Leu Thr Arg 
                325                 330                 335


Ala Gln Met Val Glu Ser Asn Leu Gln Asp Lys Tyr Gln Ser Phe Lys 
            340                 345                 350


His Phe Arg Val Gln Tyr Glu Met Lys Arg Lys Gln Ile Glu His Leu 
        355                 360                 365


Ile Gln Pro Leu His Arg Asp Gly Lys Leu Ser Leu Asp Gln Ala Leu 
    370                 375                 380


Val Lys Gln Ser Trp Asp Arg Val Thr Ser Arg Leu Phe Asp Trp His 
385                 390                 395                 400


Ile Gln Leu Asp Lys Ser Leu Pro Ala Pro Leu Gly Thr Ile Gly Ala 
                405                 410                 415


Trp Leu Tyr Arg Ala Glu Val Ala Leu Arg Glu Glu Ile Thr Val Gln 
            420                 425                 430


Gln Val His Glu Glu Thr Ala Asn Thr Ile Gln Arg Lys Leu Glu Gln 
        435                 440                 445


His Lys Asp Leu Leu Gln Asn Thr Asp Ala His Lys Arg Ala Phe His 
    450                 455                 460


Glu Ile Tyr Arg Thr Arg Ser Val Asn Gly Ile Pro Val Pro Pro Asp 
465                 470                 475                 480


Gln Leu Glu Asp Met Ala Glu Arg Phe His Phe Val Ser Ser Thr Ser 
                485                 490                 495


Glu Leu His Leu Met Lys Met Glu Phe Leu Glu Leu Lys Tyr Arg Leu 
            500                 505                 510


Leu Ser Leu Leu Val Leu Ala Glu Ser Lys Leu Lys Ser Trp Ile Ile 
        515                 520                 525


Lys Tyr Gly Arg Arg Glu Ser Val Glu Gln Leu Leu Gln Asn Tyr Val 
    530                 535                 540


Ser Phe Ile Glu Asn Ser Lys Phe Phe Glu Gln Tyr Glu Val Thr Tyr 
545                 550                 555                 560


Gln Ile Leu Lys Gln Thr Ala Glu Met Tyr Val Lys Ala Asp Gly Ser 
                565                 570                 575


Val Glu Glu Ala Glu Asn Val Met Lys Phe Met Asn Glu Thr Thr Ala 
            580                 585                 590


Gln Trp Arg Asn Leu Ser Val Glu Val Arg Ser Val Arg Ser Met Leu 
        595                 600                 605


Glu Glu Val Ile Ser Asn Trp Asp Arg Tyr Gly Asn Thr Val Ala Ser 
    610                 615                 620


Leu Gln Ala Trp Leu Glu Asp Ala Glu Lys Met Leu Asn Gln Ser Glu 
625                 630                 635                 640


Asn Ala Lys Lys Asp Phe Phe Arg Asn Leu Pro His Trp Ile Gln Gln 
                645                 650                 655


His Thr Ala Met Asn Asp Ala Gly Asn Phe Leu Ile Glu Thr Cys Asp 
            660                 665                 670


Glu Met Val Ser Arg Asp Leu Lys Gln Gln Leu Leu Leu Leu Asn Gly 
        675                 680                 685


Arg Trp Arg Glu Leu Phe Met Glu Val Lys Gln Tyr Ala Gln Ala Asp 
    690                 695                 700


Glu Met Asp Arg Met Lys Lys Glu Tyr Thr Asp Cys Val Val Thr Leu 
705                 710                 715                 720


Ser Ala Phe Ala Thr Glu Ala His Lys Lys Leu Ser Glu Pro Leu Glu 
                725                 730                 735


Val Ser Phe Met Asn Val Lys Leu Leu Ile Gln Asp Leu Glu Asp Ile 
            740                 745                 750


Glu Gln Arg Val Pro Val Met Asp Ala Gln Tyr Lys Ile Ile Thr Lys 
        755                 760                 765


Thr Ala His Leu Ile Thr Lys Glu Ser Pro Gln Glu Glu Gly Lys Glu 
    770                 775                 780


Met Phe Ala Thr Met Ser Lys Leu Lys Glu Gln Leu Thr Lys Val Lys 
785                 790                 795                 800


Glu Cys Tyr Ser Pro Leu Leu Tyr Glu Ser Gln Gln Leu Leu Ile Pro 
                805                 810                 815


Leu Glu Glu Leu Glu Lys Gln Met Thr Ser Phe Tyr Asp Ser Leu Gly 
            820                 825                 830


Lys Ile Asn Glu Ile Ile Thr Val Leu Glu Arg Glu Ala Gln Ser Ser 
        835                 840                 845


Ala Leu Phe Lys Gln Lys His Gln Glu Leu Leu Ala Cys Gln Glu Asn 
    850                 855                 860


Cys Lys Lys Thr Leu Thr Leu Ile Glu Lys Gly Ser Gln Ser Val Gln 
865                 870                 875                 880


Lys Phe Val Thr Leu Ser Asn Val Leu Lys His Phe Asp Gln Thr Arg 
                885                 890                 895


Leu Gln Arg Gln Ile Ala Asp Ile His Val Ala Phe Gln Ser Met Val 
            900                 905                 910


Lys Lys Thr Gly Asp Trp Lys Lys His Val Glu Thr Asn Ser Arg Leu 
        915                 920                 925


Met Lys Lys Phe Glu Glu Ser Arg Ala Glu Leu Glu Lys Val Leu Arg 
    930                 935                 940


Ile Ala Gln Glu Gly Leu Glu Glu Lys Gly Asp Pro Glu Glu Leu Leu 
945                 950                 955                 960


Arg Arg His Thr Glu Phe Phe Ser Gln Leu Asp Gln Arg Val Leu Asn 
                965                 970                 975


Ala Phe Leu Lys Ala Cys Asp Glu Leu Thr Asp Ile Leu Pro Glu Gln 
            980                 985                 990


Glu Gln Gln Gly Leu Gln Glu Ala Val Arg Lys Leu His Lys Gln Trp 
        995                 1000                1005


Lys Asp Leu Gln Gly Glu Ala Pro Tyr His Leu Leu His Leu Lys Ile 
    1010                1015                1020


Asp Val Glu Lys Asn Arg Phe Leu Ala Ser Val Glu Glu Cys Arg Thr 
1025                1030                1035                1040


Glu Leu Asp Arg Glu Thr Lys Leu Met Pro Gln Glu Gly Ser Glu Lys 
                1045                1050                1055


Ile Ile Lys Glu His Arg Val Phe Phe Ser Asp Lys Gly Pro His His 
            1060                1065                1070


Leu Cys Glu Lys Arg Leu Gln Leu Ile Glu Glu Leu Cys Val Lys Leu 
        1075                1080                1085


Pro Val Arg Asp Pro Val Arg Asp Thr Pro Gly Thr Cys His Val Thr 
    1090                1095                1100


Leu Lys Glu Leu Arg Ala Ala Ile Asp Ser Thr Tyr Arg Lys Leu Met 
1105                1110                1115                1120


Glu Asp Pro Asp Lys Trp Lys Asp Tyr Thr Ser Arg Phe Ser Glu Phe 
                1125                1130                1135


Ser Ser Trp Ile Ser Thr Asn Glu Thr Gln Leu Lys Gly Ile Lys Gly 
            1140                1145                1150


Glu Ala Ile Asp Thr Ala Asn His Gly Glu Val Lys Arg Ala Val Glu 
        1155                1160                1165


Glu Ile Arg Asn Gly Val Thr Lys Arg Gly Glu Thr Leu Ser Trp Leu 
    1170                1175                1180


Lys Ser Arg Leu Lys Val Leu Thr Glu Val Ser Ser Glu Asn Glu Ala 
1185                1190                1195                1200


Gln Lys Gln Gly Asp Glu Leu Ala Lys Leu Ser Ser Ser Phe Lys Ala 
                1205                1210                1215


Leu Val Thr Leu Leu Ser Glu Val Glu Lys Met Leu Ser Asn Phe Gly 
            1220                1225                1230


Asp Cys Val Gln Tyr Lys Glu Ile Val Lys Asn Ser Leu Glu Glu Leu 
        1235                1240                1245


Ile Ser Gly Ser Lys Glu Val Gln Glu Gln Ala Glu Lys Ile Leu Asp 
    1250                1255                1260


Thr Glu Asn Leu Phe Glu Ala Gln Gln Leu Leu Leu His His Gln Gln 
1265                1270                1275                1280


Lys Thr Lys Arg Ile Ser Ala Lys Lys Arg Asp Val Gln Gln Gln Ile 
                1285                1290                1295


Ala Gln Ala Gln Gln Gly Glu Gly Gly Leu Pro Asp Arg Gly His Glu 
            1300                1305                1310


Glu Leu Arg Lys Leu Glu Ser Thr Leu Asp Gly Leu Glu Arg Ser Arg 
        1315                1320                1325


Glu Arg Gln Glu Arg Arg Ile Gln Val Thr Leu Arg Lys Trp Glu Arg 
    1330                1335                1340


Phe Glu Thr Asn Lys Glu Thr Val Val Arg Tyr Leu Phe Gln Thr Gly 
1345                1350                1355                1360


Ser Ser His Glu Arg Phe Leu Ser Phe Ser Ser Leu Glu Ser Leu Ser 
                1365                1370                1375


Ser Glu Leu Glu Gln Thr Lys Glu Phe Ser Lys Arg Thr Glu Ser Ile 
            1380                1385                1390


Ala Val Gln Ala Glu Asn Leu Val Lys Glu Ala Ser Glu Ile Pro Leu 
        1395                1400                1405


Gly Pro Gln Asn Lys Gln Leu Leu Gln Gln Gln Ala Lys Ser Ile Lys 
    1410                1415                1420


Glu Gln Val Lys Lys Leu Glu Asp Thr Leu Glu Glu Asp Ile Lys Thr 
1425                1430                1435                1440


Met Glu Met Val Lys Thr Lys Trp Asp His Phe Gly Ser Asn Phe Glu 
                1445                1450                1455


Thr Leu Ser Val Trp Ile Thr Glu Lys Glu Lys Glu Leu Asn Ala Leu 
            1460                1465                1470


Glu Thr Ser Ser Ser Ala Met Asp Met Gln Ile Ser Gln Ile Lys Val 
        1475                1480                1485


Thr Ile Gln Glu Ile Glu Ser Lys Leu Ser Ser Ile Val Gly Leu Glu 
    1490                1495                1500


Glu Glu Ala Gln Ser Phe Ala Gln Phe Val Thr Thr Gly Glu Ser Ala 
1505                1510                1515                1520


Arg Ile Lys Ala Lys Leu Thr Gln Ile Arg Arg Tyr Gly Glu Glu Leu 
                1525                1530                1535


Arg Glu His Ala Gln Cys Leu Glu Gly Thr Ile Leu Gly His Leu Ser 
            1540                1545                1550


Gln Gln Gln Lys Phe Glu Glu Asn Leu Arg Lys Ile Gln Gln Ser Val 
        1555                1560                1565


Ser Glu Phe Glu Asp Lys Leu Ala Val Pro Ile Lys Ile Cys Ser Ser 
    1570                1575                1580


Ala Thr Glu Thr Tyr Lys Val Leu Gln Glu His Met Asp Leu Cys Gln 
1585                1590                1595                1600


Ala Leu Glu Ser Leu Ser Ser Ala Ile Thr Ala Phe Ser Ala Ser Ala 
                1605                1610                1615


Arg Lys Val Val Asn Arg Asp Ser Cys Val Gln Glu Ala Ala Ala Leu 
            1620                1625                1630


Gln Gln Gln Tyr Glu Asp Ile Leu Arg Arg Ala Lys Glu Arg Gln Thr 
        1635                1640                1645


Ala Leu Glu Asn Leu Leu Ala His Trp Gln Arg Leu Glu Lys Glu Leu 
    1650                1655                1660


Ser Ser Phe Leu Thr Trp Leu Glu Arg Gly Glu Ala Lys Ala Ser Ser 
1665                1670                1675                1680


Pro Glu Met Asp Ile Ser Ala Asp Arg Val Lys Val Glu Gly Glu Leu 
                1685                1690                1695


Gln Leu Ile Gln Ala Leu Gln Asn Glu Val Val Ser Gln Ala Ser Phe 
            1700                1705                1710


Tyr Ser Lys Leu Leu Gln Leu Lys Glu Ser Leu Phe Ser Val Ala Ser 
        1715                1720                1725


Lys Asp Asp Val Lys Met Met Lys Leu His Leu Glu Gln Leu Asp Glu 
    1730                1735                1740


Arg Trp Arg Asp Leu Pro Gln Ile Ile Asn Lys Arg Ile Asn Phe Leu 
1745                1750                1755                1760


Gln Ser Val Val Ala Glu His Gln Gln Phe Asp Glu Leu Leu Leu Ser 
                1765                1770                1775


Phe Ser Val Trp Ile Lys Leu Phe Leu Ser Glu Leu Gln Thr Thr Ser 
            1780                1785                1790


Glu Ile Ser Ile Met Asp His Gln Val Ala Leu Thr Arg His Lys Asp 
        1795                1800                1805


His Ala Ala Glu Val Glu Ser Lys Lys Gly Glu Leu Gln Ser Leu Gln 
    1810                1815                1820


Gly His Leu Ala Lys Leu Gly Ser Leu Gly Arg Ala Glu Asp Leu His 
1825                1830                1835                1840


Leu Leu Gln Gly Lys Ala Glu Asp Cys Phe Gln Leu Phe Glu Glu Ala 
                1845                1850                1855


Ser Gln Val Val Glu Arg Arg Gln Leu Ala Leu Ser His Leu Ala Glu 
            1860                1865                1870


Phe Leu Gln Ser His Ala Ser Leu Ser Gly Ile Leu Arg Gln Leu Arg 
        1875                1880                1885


Gln Thr Val Glu Ala Thr Asn Ser Met Asn Lys Asn Glu Ser Asp Leu 
    1890                1895                1900


Ile Glu Lys Asp Leu Asn Asp Ala Leu Gln Asn Ala Lys Ala Leu Glu 
1905                1910                1915                1920


Ser Ala Ala Val Ser Leu Asp Gly Ile Leu Ser Lys Ala Gln Tyr His 
                1925                1930                1935


Leu Lys Ile Gly Ser Ser Glu Gln Arg Thr Ser Cys Arg Ala Thr Ala 
            1940                1945                1950


Asp Gln Leu Cys Gly Glu Val Glu Arg Ile Gln Asn Leu Leu Gly Thr 
        1955                1960                1965


Lys Gln Ser Glu Ala Asp Ala Leu Ala Val Leu Lys Lys Ala Phe Gln 
    1970                1975                1980


Asp Gln Lys Glu Glu Leu Leu Lys Ser Ile Glu Asp Ile Glu Glu Arg 
1985                1990                1995                2000


Thr Asp Lys Glu Arg Leu Lys Glu Pro Thr Arg Gln Ala Leu Gln Gln 
                2005                2010                2015


Arg Leu Arg Val Phe Asn Gln Leu Glu Asp Glu Leu Asn Ser His Glu 
            2020                2025                2030


His Glu Leu Cys Trp Leu Lys Asp Lys Ala Lys Gln Ile Ala Gln Lys 
        2035                2040                2045


Asp Val Ala Phe Ala Pro Glu Val Asp Arg Glu Ile Asn Arg Leu Glu 
    2050                2055                2060


Val Thr Trp Asp Asp Thr Lys Arg Leu Ile His Glu Asn Gln Gly Gln 
2065                2070                2075                2080


Cys Cys Gly Leu Ile Asp Leu Met Arg Glu Tyr Gln Asn Leu Lys Ser 
                2085                2090                2095


Ala Val Ser Lys Val Leu Glu Asn Ala Ser Ser Val Ile Val Thr Arg 
            2100                2105                2110


Thr Thr Ile Lys Asp Gln Glu Asp Leu Lys Trp Ala Phe Ser Lys His 
        2115                2120                2125


Glu Thr Ala Lys Asn Lys Met Asn Tyr Lys Gln Lys Asp Leu Asp Asn 
    2130                2135                2140


Phe Thr Ser Lys Gly Lys His Leu Leu Ser Glu Leu Lys Lys Ile His 
2145                2150                2155                2160


Ser Ser Asp Phe Ser Leu Val Lys Thr Asp Met Glu Ser Thr Val Asp 
                2165                2170                2175


Lys Trp Leu Asp Val Ser Glu Lys Leu Glu Glu Asn Met Asp Arg Leu 
            2180                2185                2190


Arg Val Ser Leu Ser Ile Trp Asp Asp Val Leu Ser Thr Arg Asp Glu 
        2195                2200                2205


Ile Glu Gly Trp Ser Asn Asn Cys Val Pro Gln Met Ala Glu Asn Ile 
    2210                2215                2220


Ser Asn Leu Asp Asn His Leu Arg Ala Glu Glu Leu Leu Lys Glu Phe 
2225                2230                2235                2240


Glu Ser Glu Val Lys Asn Lys Ala Leu Arg Leu Glu Glu Leu His Ser 
                2245                2250                2255


Lys Val Asn Asp Leu Lys Glu Leu Thr Lys Asn Leu Glu Thr Pro Pro 
            2260                2265                2270


Asp Leu Gln Phe Ile Glu Ala Asp Leu Met Gln Lys Leu Glu His Ala 
        2275                2280                2285


Lys Glu Ile Thr Glu Val Ala Lys Gly Thr Leu Lys Asp Phe Thr Ala 
    2290                2295                2300


Gln Ser Thr Gln Val Glu Lys Phe Ile Asn Asp Ile Thr Thr Trp Phe 
2305                2310                2315                2320


Thr Lys Val Glu Glu Ser Leu Met Asn Cys Ala Gln Asn Glu Thr Cys 
                2325                2330                2335


Glu Ala Leu Lys Lys Val Lys Asp Ile Gln Lys Glu Leu Gln Ser Gln 
            2340                2345                2350


Gln Ser Asn Ile Ser Ser Thr Gln Glu Asn Leu Asn Ser Leu Cys Arg 
        2355                2360                2365


Lys Tyr His Ser Ala Glu Leu Glu Ser Leu Gly Arg Ala Met Thr Gly 
    2370                2375                2380


Leu Ile Lys Lys His Glu Ala Val Ser Gln Leu Cys Ser Lys Thr Gln 
2385                2390                2395                2400


Ala Ser Leu Gln Glu Ser Leu Glu Lys His Phe Ser Glu Ser Met Gln 
                2405                2410                2415


Glu Phe Gln Glu Trp Phe Leu Gly Ala Lys Ala Ala Ala Lys Glu Ser 
            2420                2425                2430


Ser Asp Arg Thr Gly Asp Ser Lys Val Leu Glu Ala Lys Leu His Asp 
        2435                2440                2445


Leu Gln Asn Ile Leu Asp Ser Val Ser Asp Gly Gln Ser Lys Leu Asp 
    2450                2455                2460


Ala Val Thr Gln Glu Gly Gln Thr Leu Tyr Ala His Leu Ser Lys Gln 
2465                2470                2475                2480


Ile Val Ser Ser Ile Gln Glu Gln Ile Thr Lys Ala Asn Glu Glu Phe 
                2485                2490                2495


Gln Ala Phe Leu Lys Gln Cys Leu Lys Asp Lys Gln Ala Leu Gln Asp 
            2500                2505                2510


Cys Ala Ser Glu Leu Gly Ser Phe Glu Asp Gln His Arg Lys Leu Asn 
        2515                2520                2525


Leu Trp Ile His Glu Met Glu Glu Arg Phe Asn Thr Glu Asn Leu Gly 
    2530                2535                2540


Glu Ser Lys Gln His Ile Pro Glu Lys Lys Asn Glu Val His Lys Val 
2545                2550                2555                2560


Glu Met Phe Leu Gly Glu Leu Leu Ala Ala Arg Glu Ser Leu Asp Lys 
                2565                2570                2575


Leu Ser Gln Arg Gly Gln Leu Leu Ser Glu Glu Gly His Gly Ala Gly 
            2580                2585                2590


Gln Glu Gly Arg Leu Cys Ser Gln Leu Leu Thr Ser His Gln Asn Leu 
        2595                2600                2605


Leu Arg Met Thr Lys Glu Lys Leu Arg Ser Cys Gln Val Ala Leu Gln 
    2610                2615                2620


Glu His Glu Ala Leu Glu Glu Ala Leu Gln Ser Met Trp Phe Trp Val 
2625                2630                2635                2640


Lys Ala Ile Gln Asp Arg Leu Ala Cys Ala Glu Ser Thr Leu Gly Ser 
                2645                2650                2655


Lys Asp Thr Leu Glu Lys Arg Leu Ser Gln Ile Gln Asp Ile Leu Leu 
            2660                2665                2670


Met Lys Gly Glu Gly Glu Val Lys Leu Asn Met Ala Ile Gly Lys Gly 
        2675                2680                2685


Glu Gln Ala Leu Arg Ser Ser Asn Lys Glu Gly Gln Arg Val Ile Gln 
    2690                2695                2700


Thr Gln Leu Glu Thr Leu Lys Glu Val Trp Ala Asp Ile Met Ser Ser 
2705                2710                2715                2720


Ser Val His Ala Gln Ser Thr Leu Glu Ser Val Ile Ser Gln Trp Asn 
                2725                2730                2735


Asp Tyr Val Glu Arg Lys Asn Gln Leu Glu Gln Trp Met Glu Ser Val 
            2740                2745                2750


Asp Gln Lys Ile Glu His Pro Leu Gln Pro Gln Pro Gly Leu Lys Glu 
        2755                2760                2765


Lys Phe Val Leu Leu Asp His Leu Gln Ser Ile Leu Ser Glu Ala Glu 
    2770                2775                2780


Asp His Thr Arg Ala Leu His Arg Leu Ile Ala Lys Ser Arg Glu Leu 
2785                2790                2795                2800


Tyr Glu Lys Thr Glu Asp Glu Ser Phe Lys Asp Thr Ala Gln Glu Glu 
                2805                2810                2815


Leu Lys Thr Gln Phe Asn Asp Ile Met Thr Val Ala Lys Glu Lys Met 
            2820                2825                2830


Arg Lys Val Glu Glu Ile Val Lys Asp His Leu Met Tyr Leu Asp Ala 
        2835                2840                2845


Val His Glu Phe Thr Asp Trp Leu His Ser Ala Lys Glu Glu Leu His 
    2850                2855                2860


Arg Trp Ser Asp Met Ser Gly Asp Ser Ser Ala Thr Gln Lys Lys Leu 
2865                2870                2875                2880


Ser Lys Ile Lys Glu Leu Ile Asp Ser Arg Glu Ile Gly Ala Ser Arg 
                2885                2890                2895


Leu Ser Arg Val Glu Ser Leu Ala Pro Glu Val Lys Gln Asn Thr Thr 
            2900                2905                2910


Ala Ser Gly Cys Glu Leu Met His Thr Glu Met Gln Ala Leu Arg Ala 
        2915                2920                2925


Asp Trp Lys Gln Trp Glu Asp Ser Val Phe Gln Thr Gln Ser Cys Leu 
    2930                2935                2940


Glu Asn Leu Val Ser Gln Met Ala Leu Ser Glu Gln Glu Phe Ser Gly 
2945                2950                2955                2960


Gln Val Ala Gln Leu Glu Gln Ala Leu Glu Gln Phe Ser Ala Leu Leu 
                2965                2970                2975


Lys Thr Trp Ala Gln Gln Leu Thr Leu Leu Glu Gly Lys Asn Thr Asp 
            2980                2985                2990


Glu Glu Ile Val Glu Cys Trp His Lys Gly Gln Glu Ile Leu Asp Ala 
        2995                3000                3005


Leu Gln Lys Ala Glu Pro Arg Thr Glu Asp Leu Lys Ser Gln Leu Asn 
    3010                3015                3020


Glu Leu Cys Arg Phe Ser Arg Asp Leu Ser Thr Tyr Ser Gly Lys Val 
3025                3030                3035                3040


Ser Gly Leu Ile Lys Glu Tyr Asn Cys Leu Cys Leu Gln Ala Ser Lys 
                3045                3050                3055


Gly Cys Gln Asn Lys Glu Gln Ile Leu Gln Gln Arg Phe Arg Lys Ala 
            3060                3065                3070


Phe Arg Asp Phe Gln Gln Trp Leu Val Asn Ala Lys Ile Thr Thr Ala 
        3075                3080                3085


Lys Cys Phe Asp Ile Pro Gln Asn Ile Ser Glu Val Ser Thr Ser Leu 
    3090                3095                3100


Gln Lys Ile Gln Glu Phe Leu Ser Glu Ser Glu Asn Gly Gln His Lys 
3105                3110                3115                3120


Leu Asn Met Met Leu Ser Lys Gly Glu Leu Leu Ser Thr Leu Leu Thr 
                3125                3130                3135


Lys Glu Lys Ala Lys Gly Ile Gln Ala Lys Val Thr Ala Ala Lys Glu 
            3140                3145                3150


Asp Trp Lys Asn Phe His Ser Asn Leu His Gln Lys Glu Ser Ala Leu 
        3155                3160                3165


Glu Asn Leu Lys Ile Gln Met Lys Asp Phe Glu Val Ser Ala Glu Pro 
    3170                3175                3180


Ile Gln Asp Trp Leu Ser Lys Thr Glu Lys Met Val His Glu Ser Ser 
3185                3190                3195                3200


Asn Arg Leu Tyr Asp Leu Pro Ala Lys Arg Arg Glu Gln Gln Lys Leu 
                3205                3210                3215


Gln Ser Val Leu Glu Glu Ile His Cys Tyr Glu Pro Gln Leu Asn Arg 
            3220                3225                3230


Leu Lys Glu Lys Ala Gln Gln Leu Trp Glu Gly Gln Ala Ala Ser Lys 
        3235                3240                3245


Ser Phe Arg His Arg Val Ser Gln Leu Ser Ser Gln Tyr Leu Ala Leu 
    3250                3255                3260


Ser Asn Leu Thr Lys Glu Lys Val Ser Arg Leu Asp Arg Ile Val Ala 
3265                3270                3275                3280


Glu His Asn Gln Phe Ser Leu Gly Ile Lys Glu Leu Gln Asp Trp Met 
                3285                3290                3295


Thr Asp Ala Ile His Met Leu Asp Ser Tyr Cys His Pro Thr Ser Asp 
            3300                3305                3310


Lys Ser Val Leu Asp Ser Arg Thr Leu Lys Leu Glu Ala Leu Leu Ser 
        3315                3320                3325


Val Lys Gln Glu Lys Glu Ile Gln Met Lys Met Ile Val Thr Arg Gly 
    3330                3335                3340


Glu Ser Val Leu Gln Asn Thr Ser Pro Glu Gly Ile Pro Thr Ile Gln 
3345                3350                3355                3360


Gln Gln Leu Gln Ser Val Lys Asp Met Trp Ala Ser Leu Leu Ser Ala 
                3365                3370                3375


Gly Ile Arg Cys Lys Ser Gln Leu Glu Gly Ala Leu Ser Lys Trp Thr 
            3380                3385                3390


Ser Tyr Gln Asp Gly Val Arg Gln Phe Ser Gly Trp Met Asp Ser Met 
        3395                3400                3405


Glu Ala Asn Leu Asn Glu Ser Glu Arg Gln His Ala Glu Leu Arg Asp 
    3410                3415                3420


Lys Thr Thr Met Leu Gly Lys Ala Lys Leu Leu Asn Glu Glu Val Leu 
3425                3430                3435                3440


Ser Tyr Ser Ser Leu Leu Glu Thr Ile Glu Val Lys Gly Ala Gly Met 
                3445                3450                3455


Thr Glu His Tyr Val Thr Gln Leu Glu Leu Gln Asp Leu Gln Glu Arg 
            3460                3465                3470


Tyr Arg Ala Ile Gln Glu Arg Ala Lys Glu Ala Val Thr Lys Ser Glu 
        3475                3480                3485


Lys Leu Val Arg Leu His Gln Glu Tyr Gln Arg Asp Leu Lys Ala Phe 
    3490                3495                3500


Glu Val Trp Leu Gly Gln Glu Gln Glu Lys Leu Asp Gln Tyr Ser Val 
3505                3510                3515                3520


Leu Glu Gly Asp Ala His Thr His Glu Thr Thr Leu Arg Asp Leu Gln 
                3525                3530                3535


Glu Leu Gln Val His Cys Ala Glu Gly Gln Ala Leu Leu Asn Ser Val 
            3540                3545                3550


Leu His Thr Arg Glu Asp Val Ile Pro Ser Gly Ile Pro Gln Ala Glu 
        3555                3560                3565


Asp Arg Ala Leu Glu Ser Leu Arg Gln Asp Trp Gln Ala Tyr Gln His 
    3570                3575                3580


Arg Leu Ser Glu Thr Arg Thr Gln Phe Asn Asn Val Val Asn Lys Leu 
3585                3590                3595                3600


Arg Leu Met Glu Gln Lys Phe Gln Gln Val Asp Glu Trp Leu Lys Thr 
                3605                3610                3615


Ala Glu Glu Lys Val Ser Pro Arg Thr Arg Arg Gln Ser Asn Arg Ala 
            3620                3625                3630


Thr Lys Glu Ile Gln Leu His Gln Met Lys Lys Trp His Glu Glu Val 
        3635                3640                3645


Thr Ala Tyr Arg Asp Glu Val Glu Glu Val Gly Ala Arg Ala Gln Glu 
    3650                3655                3660


Ile Leu Asp Glu Ser His Val Asn Ser Arg Met Gly Cys Gln Ala Thr 
3665                3670                3675                3680


Gln Leu Thr Ser Arg Tyr Gln Ala Leu Leu Leu Gln Val Leu Glu Gln 
                3685                3690                3695


Ile Lys Phe Leu Glu Glu Glu Ile Gln Ser Leu Glu Glu Ser Glu Ser 
            3700                3705                3710


Ser Leu Ser Ser Tyr Ser Asp Trp Tyr Gly Ser Thr His Lys Asn Phe 
        3715                3720                3725


Lys Asn Val Ala Thr Lys Ile Asp Lys Val Asp Thr Val Met Met Gly 
    3730                3735                3740


Lys Lys Leu Lys Thr Leu Glu Val Leu Leu Lys Asp Met Glu Lys Gly 
3745                3750                3755                3760


His Ser Leu Leu Lys Ser Ala Arg Glu Lys Gly Glu Arg Ala Val Lys 
                3765                3770                3775


Tyr Leu Glu Glu Gly Glu Ala Glu Arg Leu Arg Lys Glu Ile His Asp 
            3780                3785                3790


His Met Glu Gln Leu Lys Glu Leu Thr Ser Thr Val Arg Lys Glu His 
        3795                3800                3805


Met Thr Leu Glu Lys Gly Leu His Leu Ala Lys Glu Phe Ser Asp Lys 
    3810                3815                3820


Cys Lys Ala Leu Thr Gln Trp Ile Ala Glu Tyr Gln Glu Ile Leu His 
3825                3830                3835                3840


Val Pro Glu Glu Pro Lys Met Glu Leu Tyr Glu Lys Lys Ala Gln Leu 
                3845                3850                3855


Ser Lys Tyr Lys Ser Leu Gln Gln Thr Val Leu Ser His Glu Pro Ser 
            3860                3865                3870


Val Lys Ser Val Arg Glu Lys Gly Glu Ala Leu Leu Glu Leu Val Gln 
        3875                3880                3885


Asp Val Thr Leu Lys Asp Lys Ile Asp Gln Leu Gln Ser Asp Tyr Gln 
    3890                3895                3900


Asp Leu Cys Ser Ile Gly Lys Glu His Val Phe Ser Leu Glu Ala Lys 
3905                3910                3915                3920


Val Lys Asp His Glu Asp Tyr Asn Ser Glu Leu Gln Glu Val Glu Lys 
                3925                3930                3935


Trp Leu Leu Gln Met Ser Gly Arg Leu Val Ala Pro Asp Leu Leu Glu 
            3940                3945                3950


Thr Ser Ser Leu Glu Thr Ile Thr Gln Gln Leu Ala His His Lys Ala 
        3955                3960                3965


Met Met Glu Glu Ile Ala Gly Phe Glu Asp Arg Leu Asn Asn Leu Gln 
    3970                3975                3980


Met Lys Gly Asp Thr Leu Ile Gly Gln Cys Ala Asp His Leu Gln Ala 
3985                3990                3995                4000


Lys Leu Lys Gln Asn Val His Ala His Leu Gln Gly Thr Lys Asp Ser 
                4005                4010                4015


Tyr Ser Ala Ile Cys Ser Thr Ala Gln Arg Met Tyr Gln Ser Leu Glu 
            4020                4025                4030


His Glu Leu Gln Lys His Val Ser Arg Gln Asp Thr Leu Gln Gln Cys 
        4035                4040                4045


Gln Ala Trp Leu Ser Ala Val Gln Pro Asp Leu Glu Pro Ser Pro Gln 
    4050                4055                4060


Pro Pro Leu Ser Arg Ala Glu Ala Ile Lys Gln Val Lys His Phe Arg 
4065                4070                4075                4080


Ala Leu Gln Glu Gln Ala Arg Thr Tyr Leu Asp Leu Leu Cys Ser Met 
                4085                4090                4095


Cys Asp Leu Ser Asn Ala Ser Val Lys Thr Thr Ala Lys Asp Ile Gln 
            4100                4105                4110


Gln Thr Glu Gln Thr Ile Glu Gln Lys Leu Val Gln Ala Gln Asn Leu 
        4115                4120                4125


Thr Gln Gly Trp Glu Glu Ile Lys His Leu Lys Ser Glu Leu Trp Ile 
    4130                4135                4140


Tyr Leu Gln Asp Ala Asp Gln Gln Leu Gln Asn Met Lys Arg Arg His 
4145                4150                4155                4160


Ser Glu Leu Glu Leu Asn Ile Ala Gln Asn Met Val Ser Gln Val Lys 
                4165                4170                4175


Asp Phe Val Lys Lys Leu Gln Ser Lys Gln Ala Ser Val Asn Thr Ile 
            4180                4185                4190


Ile Glu Lys Val Asn Lys Leu Thr Lys Lys Glu Glu Ser Pro Glu His 
        4195                4200                4205


Lys Glu Ile Asn His Leu Asn Asp Gln Trp Leu Asp Leu Cys Arg Gln 
    4210                4215                4220


Ser Asn Asn Leu Cys Leu Gln Arg Glu Glu Asp Leu Gln Arg Thr Arg 
4225                4230                4235                4240


Asp Tyr His Asp Cys Met Asn Val Val Glu Val Phe Leu Glu Lys Phe 
                4245                4250                4255


Thr Thr Glu Trp Asp Asn Leu Ala Arg Ser Asp Ala Glu Ser Thr Ala 
            4260                4265                4270


Val His Leu Glu Ala Leu Lys Lys Leu Ala Leu Ala Leu Gln Glu Arg 
        4275                4280                4285


Lys Tyr Ala Ile Glu Asp Leu Lys Asp Gln Lys Gln Lys Met Ile Glu 
    4290                4295                4300


His Leu Asn Leu Asp Asp Lys Glu Leu Val Lys Glu Gln Thr Ser His 
4305                4310                4315                4320


Leu Glu Gln Arg Trp Phe Gln Leu Glu Asp Leu Ile Lys Arg Lys Ile 
                4325                4330                4335


Gln Val Ser Val Thr Asn Leu Glu Glu Leu Asn Val Val Gln Ser Arg 
            4340                4345                4350


Phe Gln Glu Leu Met Glu Trp Ala Glu Glu Gln Gln Pro Asn Ile Ala 
        4355                4360                4365


Glu Ala Leu Lys Gln Ser Pro Pro Pro Asp Met Ala Gln Asn Leu Leu 
    4370                4375                4380


Met Asp His Leu Ala Ile Cys Ser Glu Leu Glu Ala Lys Gln Met Leu 
4385                4390                4395                4400


Leu Lys Ser Leu Ile Lys Asp Ala Asp Arg Val Met Ala Asp Leu Gly 
                4405                4410                4415


Leu Asn Glu Arg Gln Val Ile Gln Lys Ala Leu Ser Asp Ala Gln Ser 
            4420                4425                4430


His Val Asn Cys Leu Ser Asp Leu Val Gly Gln Arg Arg Lys Tyr Leu 
        4435                4440                4445


Asn Lys Ala Leu Ser Glu Lys Thr Gln Phe Leu Met Ala Val Phe Gln 
    4450                4455                4460


Ala Thr Ser Gln Ile Gln Gln His Glu Arg Lys Ile Met Phe Arg Glu 
4465                4470                4475                4480


His Ile Cys Leu Leu Pro Asp Asp Val Ser Lys Gln Val Lys Thr Cys 
                4485                4490                4495


Lys Ser Ala Gln Ala Ser Leu Lys Thr Tyr Gln Asn Glu Val Thr Gly 
            4500                4505                4510


Leu Trp Ala Gln Gly Arg Glu Leu Met Lys Glu Val Thr Glu Gln Glu 
        4515                4520                4525


Lys Ser Glu Val Leu Gly Lys Leu Gln Glu Leu Gln Ser Val Tyr Asp 
    4530                4535                4540


Ser Val Leu Gln Lys Cys Ser His Arg Leu Gln Glu Leu Glu Lys Asn 
4545                4550                4555                4560


Leu Val Ser Arg Lys His Phe Lys Glu Asp Phe Asp Lys Ala Cys His 
                4565                4570                4575


Trp Leu Lys Gln Ala Asp Ile Val Thr Phe Pro Glu Ile Asn Leu Met 
            4580                4585                4590


Asn Glu Ser Ser Glu Leu His Thr Gln Leu Ala Lys Tyr Gln Asn Ile 
        4595                4600                4605


Leu Glu Gln Ser Pro Glu Tyr Glu Asn Leu Leu Leu Thr Leu Gln Arg 
    4610                4615                4620


Thr Gly Gln Thr Ile Leu Pro Ser Leu Asn Glu Val Asp His Ser Tyr 
4625                4630                4635                4640


Leu Ser Glu Lys Leu Asn Ala Leu Pro Arg Gln Phe Asn Val Ile Val 
                4645                4650                4655


Ala Leu Ala Lys Asp Lys Phe Tyr Lys Val Gln Glu Ala Ile Leu Ala 
            4660                4665                4670


Arg Lys Glu Tyr Ala Ser Leu Ile Glu Leu Thr Thr Gln Ser Leu Ser 
        4675                4680                4685


Glu Leu Glu Ala Gln Phe Leu Arg Met Ser Lys Val Pro Thr Asp Leu 
    4690                4695                4700


Ala Val Glu Glu Ala Leu Ser Leu Gln Asp Gly Cys Arg Ala Ile Leu 
4705                4710                4715                4720


Asp Glu Val Ala Gly Leu Gly Glu Ala Val Asp Glu Leu Asn Gln Lys 
                4725                4730                4735


Lys Glu Gly Phe Arg Ser Thr Gly Gln Pro Trp Gln Pro Asp Lys Met 
            4740                4745                4750


Leu His Leu Val Thr Leu Tyr His Arg Leu Lys Arg Gln Thr Glu Gln 
        4755                4760                4765


Arg Val Ser Leu Leu Glu Asp Thr Thr Ser Ala Tyr Gln Glu His Glu 
    4770                4775                4780


Lys Met Cys Gln Gln Leu Glu Arg Gln Leu Lys Ser Val Lys Glu Glu 
4785                4790                4795                4800


Gln Ser Lys Val Asn Glu Glu Thr Leu Pro Ala Glu Glu Lys Leu Lys 
                4805                4810                4815


Met Tyr His Ser Leu Ala Gly Ser Leu Gln Asp Ser Gly Ile Val Leu 
            4820                4825                4830


Lys Arg Val Thr Ile His Leu Glu Asp Leu Ala Pro His Leu Asp Pro 
        4835                4840                4845


Leu Ala Tyr Glu Lys Ala Arg His Gln Ile Gln Ser Trp Gln Gly Glu 
    4850                4855                4860


Leu Lys Leu Leu Thr Ser Ala Ile Gly Glu Thr Val Thr Glu Cys Glu 
4865                4870                4875                4880


Ser Arg Met Val Gln Ser Ile Asp Phe Gln Thr Glu Met Ser Arg Ser 
                4885                4890                4895


Leu Asp Trp Leu Arg Arg Val Lys Ala Glu Leu Ser Gly Pro Val Tyr 
            4900                4905                4910


Leu Asp Leu Asn Leu Gln Asp Ile Gln Glu Glu Ile Arg Lys Ile Gln 
        4915                4920                4925


Ile His Gln Glu Glu Val Gln Ser Ser Leu Arg Ile Met Asn Ala Leu 
    4930                4935                4940


Ser His Lys Glu Lys Glu Lys Phe Thr Lys Ala Lys Glu Leu Ile Ser 
4945                4950                4955                4960


Ala Asp Leu Glu His Ser Leu Ala Glu Leu Ser Glu Leu Asp Gly Asp 
                4965                4970                4975


Ile Gln Glu Ala Leu Arg Thr Arg Gln Ala Thr Leu Thr Glu Ile Tyr 
            4980                4985                4990


Ser Gln Cys Gln Arg Tyr Tyr Gln Val Phe Gln Ala Ala Asn Asp Trp 
        4995                5000                5005


Leu Glu Asp Ala Gln Glu Leu Leu Gln Leu Ala Gly Asn Gly Leu Asp 
    5010                5015                5020


Val Glu Ser Ala Glu Glu Asn Leu Lys Ser His Met Glu Phe Phe Ser 
5025                5030                5035                5040


Thr Glu Asp Gln Phe His Ser Asn Leu Glu Glu Leu His Ser Leu Val 
                5045                5050                5055


Ala Thr Leu Asp Pro Leu Ile Lys Pro Thr Gly Lys Glu Asp Leu Glu 
            5060                5065                5070


Gln Lys Val Ala Ser Leu Glu Leu Arg Ser Gln Arg Met Ser Arg Asp 
        5075                5080                5085


Ser Gly Ala Gln Val Asp Leu Leu Gln Arg Cys Thr Ala Gln Trp His 
    5090                5095                5100


Asp Tyr Gln Lys Ala Arg Glu Glu Val Ile Glu Leu Met Asn Asp Thr 
5105                5110                5115                5120


Glu Lys Lys Leu Ser Glu Phe Ser Leu Leu Lys Thr Ser Ser Ser His 
                5125                5130                5135


Glu Ala Glu Glu Lys Leu Ser Glu His Lys Ala Leu Val Ser Val Val 
            5140                5145                5150


Asn Ser Phe His Glu Lys Ile Val Ala Leu Glu Glu Lys Ala Ser Gln 
        5155                5160                5165


Leu Glu Lys Thr Gly Asn Asp Ala Ser Lys Ala Thr Leu Ser Arg Ser 
    5170                5175                5180


Met Thr Thr Val Trp Gln Arg Trp Thr Arg Leu Arg Ala Val Ala Gln 
5185                5190                5195                5200


Asp Gln Glu Lys Ile Leu Glu Asp Ala Val Asp Glu Trp Thr Gly Phe 
                5205                5210                5215


Asn Asn Lys Val Lys Lys Ala Thr Glu Met Ile Asp Gln Leu Gln Asp 
            5220                5225                5230


Lys Leu Pro Gly Ser Ser Ala Glu Lys Ala Ser Lys Ala Glu Leu Leu 
        5235                5240                5245


Thr Leu Leu Glu Tyr His Asp Thr Phe Val Leu Glu Leu Glu Gln Gln 
    5250                5255                5260


Gln Ser Ala Leu Gly Met Leu Arg Gln Gln Thr Leu Ser Met Leu Gln 
5265                5270                5275                5280


Asp Gly Ala Ala Pro Thr Pro Gly Glu Glu Pro Pro Leu Met Gln Glu 
                5285                5290                5295


Ile Thr Ala Met Gln Asp Arg Cys Leu Asn Met Gln Glu Lys Val Lys 
            5300                5305                5310


Thr Asn Gly Lys Leu Val Lys Gln Glu Leu Lys Asp Arg Glu Met Val 
        5315                5320                5325


Glu Thr Gln Ile Asn Ser Val Lys Cys Trp Val Gln Glu Thr Lys Glu 
    5330                5335                5340


Tyr Leu Gly Asn Pro Thr Ile Glu Ile Asp Ala Gln Leu Glu Glu Leu 
5345                5350                5355                5360


Gln Ile Leu Leu Thr Glu Ala Thr Asn His Arg Gln Asn Ile Glu Lys 
                5365                5370                5375


Met Ala Glu Glu Gln Lys Glu Lys Tyr Leu Gly Leu Tyr Thr Ile Leu 
            5380                5385                5390


Pro Ser Glu Leu Ser Leu Gln Leu Ala Glu Val Ala Leu Asp Leu Lys 
        5395                5400                5405


Ile Arg Asp Gln Ile Gln Asp Lys Ile Lys Glu Val Glu Gln Ser Lys 
    5410                5415                5420


Ala Thr Ser Gln Glu Leu Ser Arg Gln Ile Gln Lys Leu Ala Lys Asp 
5425                5430                5435                5440


Leu Thr Thr Ile Leu Thr Lys Leu Lys Ala Lys Thr Asp Asn Val Val 
                5445                5450                5455


Gln Ala Lys Thr Asp Gln Lys Val Leu Gly Glu Glu Leu Asp Gly Cys 
            5460                5465                5470


Asn Ser Lys Leu Met Glu Leu Asp Ala Ala Val Gln Lys Phe Leu Glu 
        5475                5480                5485


Gln Asn Gly Gln Leu Gly Lys Pro Leu Ala Lys Lys Ile Gly Lys Leu 
    5490                5495                5500


Thr Glu Leu His Gln Gln Thr Ile Arg Gln Ala Glu Asn Arg Leu Ser 
5505                5510                5515                5520


Lys Leu Asn Gln Ala Ala Ser His Leu Glu Glu Tyr Asn Glu Met Leu 
                5525                5530                5535


Glu Leu Ile Leu Lys Trp Ile Glu Lys Ala Lys Val Leu Ala His Gly 
            5540                5545                5550


Thr Ile Ala Trp Asn Ser Ala Ser Gln Leu Arg Glu Gln Tyr Ile Leu 
        5555                5560                5565


His Gln Thr Leu Leu Glu Glu Ser Lys Glu Ile Asp Ser Glu Leu Glu 
    5570                5575                5580


Ala Met Thr Glu Lys Leu Gln Tyr Leu Thr Ser Val Tyr Cys Thr Glu 
5585                5590                5595                5600


Lys Met Ser Gln Gln Val Ala Glu Leu Gly Arg Glu Thr Glu Glu Leu 
                5605                5610                5615


Arg Gln Met Ile Lys Ile Arg Leu Gln Asn Leu Gln Asp Ala Ala Lys 
            5620                5625                5630


Asp Met Lys Lys Phe Glu Ala Glu Leu Lys Lys Leu Gln Ala Ala Leu 
        5635                5640                5645


Glu Gln Ala Gln Ala Thr Leu Thr Ser Pro Glu Val Gly Arg Leu Ser 
    5650                5655                5660


Leu Lys Glu Gln Leu Ser His Arg Gln His Leu Leu Ser Glu Met Glu 
5665                5670                5675                5680


Ser Leu Lys Pro Lys Val Gln Ala Val Gln Leu Cys Gln Ser Ala Leu 
                5685                5690                5695


Arg Ile Pro Glu Asp Val Val Ala Ser Leu Pro Leu Cys His Ala Ala 
            5700                5705                5710


Leu Arg Leu Gln Glu Glu Ala Ser Arg Leu Gln His Thr Ala Ile Gln 
        5715                5720                5725


Gln Cys Asn Ile Met Gln Ala Ala Val Val Gln Tyr Glu Gln Tyr Glu 
    5730                5735                5740


Gln Glu Met Lys His Leu Gln Gln Leu Ile Glu Gly Ala His Arg Glu 
5745                5750                5755                5760


Ile Glu Asp Lys Pro Val Ala Thr Ser Asn Ile Gln Glu Leu Gln Ala 
                5765                5770                5775


Gln Ile Ser Arg His Glu Glu Leu Ala Gln Lys Ile Lys Gly Tyr Gln 
            5780                5785                5790


Glu Gln Ile Ala Ser Leu Asn Ser Lys Cys Lys Met Leu Thr Met Lys 
        5795                5800                5805


Ala Lys His Ala Thr Met Leu Leu Thr Val Thr Glu Val Glu Gly Leu 
    5810                5815                5820


Ala Glu Gly Thr Glu Asp Leu Asp Gly Glu Leu Leu Pro Thr Pro Ser 
5825                5830                5835                5840


Ala His Pro Ser Val Val Met Met Thr Ala Gly Arg Cys His Thr Leu 
                5845                5850                5855


Leu Ser Pro Val Thr Glu Glu Ser Gly Glu Glu Gly Thr Asn Ser Glu 
            5860                5865                5870


Ile Ser Ser Pro Pro Ala Cys Arg Ser Pro Ser Pro Val Ala Asn Thr 
        5875                5880                5885


Asp Ala Ser Val Asn Gln Asp Ile Ala Tyr Tyr Gln Ala Leu Ser Ala 
    5890                5895                5900


Glu Arg Leu Gln Thr Asp Ala Ala Lys Ile His Pro Ser Thr Ser Ala 
5905                5910                5915                5920


Ser Gln Glu Phe Tyr Glu Pro Gly Leu Glu Pro Ser Ala Thr Ala Lys 
                5925                5930                5935


Leu Gly Asp Leu Gln Arg Ser Trp Glu Thr Leu Lys Asn Val Ile Ser 
            5940                5945                5950


Glu Lys Gln Arg Thr Leu Tyr Glu Ala Leu Glu Arg Gln Gln Lys Tyr 
        5955                5960                5965


Gln Asp Ser Leu Gln Ser Ile Ser Thr Lys Met Glu Ala Ile Glu Leu 
    5970                5975                5980


Lys Leu Ser Glu Ser Pro Glu Pro Gly Arg Ser Pro Glu Ser Gln Met 
5985                5990                5995                6000


Ala Glu His Gln Ala Leu Met Asp Glu Ile Leu Met Leu Gln Asp Glu 
                6005                6010                6015


Ile Asn Glu Leu Gln Ser Ser Leu Ala Glu Glu Leu Val Ser Glu Ser 
            6020                6025                6030


Cys Glu Ala Asp Pro Ala Glu Gln Leu Ala Leu Gln Ser Thr Leu Thr 
        6035                6040                6045


Val Leu Ala Glu Arg Met Ser Thr Ile Arg Met Lys Ala Ser Gly Lys 
    6050                6055                6060


Arg Gln Leu Leu Glu Glu Lys Leu Asn Asp Gln Leu Glu Glu Gln Arg 
6065                6070                6075                6080


Gln Glu Gln Ala Leu Gln Arg Tyr Arg Cys Glu Ala Asp Glu Leu Asp 
                6085                6090                6095


Ser Trp Leu Leu Ser Thr Lys Ala Thr Leu Asp Thr Ala Leu Ser Pro 
            6100                6105                6110


Pro Lys Glu Pro Met Asp Met Glu Ala Gln Leu Met Asp Cys Gln Asn 
        6115                6120                6125


Met Leu Val Glu Ile Glu Gln Lys Val Val Ala Leu Ser Glu Leu Ser 
    6130                6135                6140


Val His Asn Glu Asn Leu Leu Leu Glu Gly Lys Ala His Thr Lys Asp 
6145                6150                6155                6160


Glu Ala Glu Gln Leu Ala Gly Lys Leu Arg Arg Leu Lys Gly Ser Leu 
                6165                6170                6175


Leu Glu Leu Gln Arg Ala Leu His Asp Lys Gln Leu Asn Met Gln Gly 
            6180                6185                6190


Thr Ala Gln Glu Lys Glu Glu Ser Asp Val Asp Leu Thr Ala Thr Gln 
        6195                6200                6205


Ser Pro Gly Val Gln Glu Trp Leu Ala Gln Ala Arg Thr Thr Trp Thr 
    6210                6215                6220


Gln Gln Arg Gln Ser Ser Leu Gln Gln Gln Lys Glu Leu Glu Gln Glu 
6225                6230                6235                6240


Leu Ala Glu Gln Lys Ser Leu Leu Arg Ser Val Ala Ser Arg Gly Glu 
                6245                6250                6255


Glu Ile Leu Ile Gln His Ser Ala Ala Glu Thr Ser Gly Asp Ala Gly 
            6260                6265                6270


Glu Lys Pro Asp Val Leu Ser Gln Glu Leu Gly Met Glu Gly Glu Lys 
        6275                6280                6285


Ser Ser Ala Glu Asp Gln Met Arg Met Lys Trp Glu Ser Leu His Gln 
    6290                6295                6300


Glu Phe Ser Thr Lys Gln Lys Leu Leu Gln Asn Val Leu Glu Gln Glu 
6305                6310                6315                6320


Gln Glu Gln Val Leu Tyr Ser Arg Pro Asn Arg Leu Leu Ser Gly Val 
                6325                6330                6335


Pro Leu Tyr Lys Gly Asp Val Pro Thr Gln Asp Lys Ser Ala Val Thr 
            6340                6345                6350


Ser Leu Leu Asp Gly Leu Asn Gln Ala Phe Glu Glu Val Ser Ser Gln 
        6355                6360                6365


Ser Gly Gly Ala Lys Arg Gln Ser Ile His Leu Glu Gln Lys Leu Tyr 
    6370                6375                6380


Asp Gly Val Ser Ala Thr Ser Thr Trp Leu Asp Asp Val Glu Glu Arg 
6385                6390                6395                6400


Leu Phe Val Ala Thr Ala Leu Leu Pro Glu Glu Thr Glu Thr Cys Leu 
                6405                6410                6415


Phe Asn Gln Glu Ile Leu Ala Lys Asp Ile Lys Glu Met Ser Glu Glu 
            6420                6425                6430


Met Asp Lys Asn Lys Asn Leu Phe Ser Gln Ala Phe Pro Glu Asn Gly 
        6435                6440                6445


Asp Asn Arg Asp Val Ile Glu Asp Thr Leu Gly Cys Leu Leu Gly Arg 
    6450                6455                6460


Leu Ser Leu Leu Asp Ser Val Val Asn Gln Arg Cys His Gln Met Lys 
6465                6470                6475                6480


Glu Arg Leu Gln Gln Ile Leu Asn Phe Gln Asn Asp Leu Lys Val Leu 
                6485                6490                6495


Phe Thr Ser Leu Ala Asp Asn Lys Tyr Ile Ile Leu Gln Lys Leu Ala 
            6500                6505                6510


Asn Val Phe Glu Gln Pro Val Ala Glu Gln Ile Glu Ala Ile Gln Gln 
        6515                6520                6525


Ala Glu Asp Gly Leu Lys Glu Phe Asp Ala Gly Ile Ile Glu Leu Lys 
    6530                6535                6540


Arg Arg Gly Asp Lys Leu Gln Val Glu Gln Pro Ser Met Gln Glu Leu 
6545                6550                6555                6560


Ser Lys Leu Gln Asp Met Tyr Asp Glu Leu Met Met Ile Ile Gly Ser 
                6565                6570                6575


Arg Arg Ser Gly Leu Asn Gln Asn Leu Thr Leu Lys Ser Gln Tyr Glu 
            6580                6585                6590


Arg Ala Leu Gln Asp Leu Ala Asp Leu Leu Glu Thr Gly Gln Glu Lys 
        6595                6600                6605


Met Ala Gly Asp Gln Lys Ile Ile Val Ser Ser Lys Glu Glu Ile Gln 
    6610                6615                6620


Gln Leu Leu Asp Lys His Lys Glu Tyr Phe Gln Gly Leu Glu Ser His 
6625                6630                6635                6640


Met Ile Leu Thr Glu Thr Leu Phe Arg Lys Ile Ile Ser Phe Ala Val 
                6645                6650                6655


Gln Lys Glu Thr Gln Phe His Thr Glu Leu Met Ala Gln Ala Ser Ala 
            6660                6665                6670


Val Leu Lys Arg Ala His Lys Arg Gly Val Glu Leu Glu Tyr Ile Leu 
        6675                6680                6685


Glu Thr Trp Ser His Leu Asp Glu Asp Gln Gln Glu Leu Ser Arg Gln 
    6690                6695                6700


Leu Glu Val Val Glu Ser Ser Ile Pro Ser Val Gly Leu Val Glu Glu 
6705                6710                6715                6720


Asn Glu Asp Arg Leu Ile Asp Arg Ile Thr Leu Tyr Gln His Leu Lys 
                6725                6730                6735


Ser Ser Leu Asn Glu Tyr Gln Pro Lys Leu Tyr Gln Val Leu Asp Asp 
            6740                6745                6750


Gly Lys Arg Leu Leu Ile Ser Ile Ser Cys Ser Asp Leu Glu Ser Gln 
        6755                6760                6765


Leu Asn Gln Leu Gly Glu Cys Trp Leu Ser Asn Thr Asn Lys Met Ser 
    6770                6775                6780


Lys Glu Leu His Arg Leu Glu Thr Ile Leu Lys His Trp Thr Arg Tyr 
6785                6790                6795                6800


Gln Ser Glu Ser Ala Asp Leu Ile His Trp Leu Gln Ser Ala Lys Asp 
                6805                6810                6815


Arg Leu Glu Phe Trp Thr Gln Gln Ser Val Thr Val Pro Gln Glu Leu 
            6820                6825                6830


Glu Met Val Arg Asp His Leu Asn Ala Phe Leu Glu Phe Ser Lys Glu 
        6835                6840                6845


Val Asp Ala Gln Ser Ser Leu Lys Ser Ser Val Leu Ser Thr Gly Asn 
    6850                6855                6860


Gln Leu Leu Arg Leu Lys Lys Val Asp Thr Ala Thr Leu Arg Ser Glu 
6865                6870                6875                6880


Leu Ser Arg Ile Asp Ser Gln Trp Thr Asp Leu Leu Thr Asn Ile Pro 
                6885                6890                6895


Ala Val Gln Glu Lys Leu His Gln Leu Gln Met Asp Lys Leu Pro Ser 
            6900                6905                6910


Arg His Ala Ile Ser Glu Val Met Ser Trp Ile Ser Leu Met Glu Asn 
        6915                6920                6925


Val Ile Gln Lys Asp Glu Asp Asn Ile Lys Asn Ser Ile Gly Tyr Lys 
    6930                6935                6940


Ala Ile His Glu Tyr Leu Gln Lys Tyr Lys Gly Phe Lys Ile Asp Ile 
6945                6950                6955                6960


Asn Cys Lys Gln Leu Thr Val Asp Phe Val Asn Gln Ser Val Leu Gln 
                6965                6970                6975


Ile Ser Ser Gln Asp Val Glu Ser Lys Arg Ser Asp Lys Thr Asp Phe 
            6980                6985                6990


Ala Glu Gln Leu Gly Ala Met Asn Lys Ser Trp Gln Ile Leu Gln Gly 
        6995                7000                7005


Leu Val Thr Glu Lys Ile Gln Leu Leu Glu Gly Leu Leu Glu Ser Trp 
    7010                7015                7020


Ser Glu Tyr Glu Asn Asn Val Gln Cys Leu Lys Thr Trp Phe Glu Thr 
7025                7030                7035                7040


Gln Glu Lys Arg Leu Lys Gln Gln His Arg Ile Gly Asp Gln Ala Ser 
                7045                7050                7055


Val Gln Asn Ala Leu Lys Asp Cys Gln Asp Leu Glu Asp Leu Ile Lys 
            7060                7065                7070


Ala Lys Glu Lys Glu Val Glu Lys Ile Glu Gln Asn Gly Leu Ala Leu 
        7075                7080                7085


Ile Gln Asn Lys Lys Glu Asp Val Ser Ser Ile Val Met Ser Thr Leu 
    7090                7095                7100


Arg Glu Leu Gly Gln Thr Trp Ala Asn Leu Asp His Met Val Gly Gln 
7105                7110                7115                7120


Leu Lys Ile Leu Leu Lys Ser Val Leu Asp Gln Trp Ser Ser His Lys 
                7125                7130                7135


Val Ala Phe Asp Lys Ile Asn Ser Tyr Leu Met Glu Ala Arg Tyr Ser 
            7140                7145                7150


Leu Ser Arg Phe Arg Leu Leu Thr Gly Ser Leu Glu Ala Val Gln Val 
        7155                7160                7165


Gln Val Asp Asn Leu Gln Asn Leu Gln Asp Asp Leu Glu Lys Gln Glu 
    7170                7175                7180


Arg Ser Leu Gln Lys Phe Gly Ser Ile Thr Asn Gln Leu Leu Lys Glu 
7185                7190                7195                7200


Cys His Pro Pro Val Thr Glu Thr Leu Thr Asn Thr Leu Lys Glu Val 
                7205                7210                7215


Asn Met Arg Trp Asn Asn Leu Leu Glu Glu Ile Ala Glu Gln Leu Gln 
            7220                7225                7230


Ser Ser Lys Ala Leu Leu Gln Leu Trp Gln Arg Tyr Lys Asp Tyr Ser 
        7235                7240                7245


Lys Gln Cys Ala Ser Thr Val Gln Gln Gln Glu Asp Arg Thr Asn Glu 
    7250                7255                7260


Leu Leu Lys Ala Ala Thr Asn Lys Asp Ile Ala Asp Asp Glu Val Ala 
7265                7270                7275                7280


Thr Trp Ile Gln Asp Cys Asn Asp Leu Leu Lys Gly Leu Gly Thr Val 
                7285                7290                7295


Lys Asp Ser Leu Phe Phe Leu His Glu Leu Gly Glu Gln Leu Lys Gln 
            7300                7305                7310


Gln Val Asp Ala Ser Ala Ala Ser Ala Ile Gln Ser Asp Gln Leu Ser 
        7315                7320                7325


Leu Ser Gln His Leu Cys Ala Leu Glu Gln Ala Leu Cys Lys Gln Gln 
    7330                7335                7340


Thr Ser Leu Gln Ala Gly Val Leu Asp Tyr Glu Thr Phe Ala Lys Ser 
7345                7350                7355                7360


Leu Glu Ala Leu Glu Ala Trp Ile Val Glu Ala Glu Glu Ile Leu Gln 
                7365                7370                7375


Gly Gln Asp Pro Ser His Ser Ser Asp Leu Ser Thr Ile Gln Glu Arg 
            7380                7385                7390


Met Glu Glu Leu Lys Gly Gln Met Leu Lys Phe Ser Ser Met Ala Pro 
        7395                7400                7405


Asp Leu Asp Arg Leu Asn Glu Leu Gly Tyr Arg Leu Pro Leu Asn Asp 
    7410                7415                7420


Lys Glu Ile Lys Arg Met Gln Asn Leu Asn Arg His Trp Ser Leu Ile 
7425                7430                7435                7440


Ser Ser Gln Thr Thr Glu Arg Phe Ser Lys Leu Gln Ser Phe Leu Leu 
                7445                7450                7455


Gln His Gln Thr Phe Leu Glu Lys Cys Glu Thr Trp Met Glu Phe Leu 
            7460                7465                7470


Val Gln Thr Glu Gln Lys Leu Ala Val Glu Ile Ser Gly Asn Tyr Gln 
        7475                7480                7485


His Leu Leu Glu Gln Gln Arg Ala His Glu Leu Phe Gln Ala Glu Met 
    7490                7495                7500


Phe Ser Arg Gln Gln Ile Leu His Ser Ile Ile Ile Asp Gly Gln Arg 
7505                7510                7515                7520


Leu Leu Glu Gln Gly Gln Val Asp Asp Arg Asp Glu Phe Asn Leu Lys 
                7525                7530                7535


Leu Thr Leu Leu Ser Asn Gln Trp Gln Gly Val Ile Arg Arg Ala Gln 
            7540                7545                7550


Gln Arg Arg Gly Ile Ile Asp Ser Gln Ile Arg Gln Trp Gln Arg Tyr 
        7555                7560                7565


Arg Glu Met Ala Glu Lys Leu Arg Lys Trp Leu Val Glu Val Ser Tyr 
    7570                7575                7580


Leu Pro Met Ser Gly Leu Gly Ser Val Pro Ile Pro Leu Gln Gln Ala 
7585                7590                7595                7600


Arg Thr Leu Phe Asp Glu Val Gln Phe Lys Glu Lys Val Phe Leu Arg 
                7605                7610                7615


Gln Gln Gly Ser Tyr Ile Leu Thr Val Glu Ala Gly Lys Gln Leu Leu 
            7620                7625                7630


Leu Ser Ala Asp Ser Gly Ala Glu Ala Ala Leu Gln Ala Glu Leu Ala 
        7635                7640                7645


Glu Ile Gln Glu Lys Trp Lys Ser Ala Ser Met Arg Leu Glu Glu Gln 
    7650                7655                7660


Lys Lys Lys Leu Ala Phe Leu Leu Lys Asp Trp Glu Lys Cys Glu Lys 
7665                7670                7675                7680


Gly Ile Ala Asp Ser Leu Glu Lys Leu Arg Thr Phe Lys Lys Lys Leu 
                7685                7690                7695


Ser Gln Ser Leu Pro Asp His His Glu Glu Leu His Ala Glu Gln Met 
            7700                7705                7710


Arg Cys Lys Glu Leu Glu Asn Ala Val Gly Ser Trp Thr Asp Asp Leu 
        7715                7720                7725


Thr Gln Leu Ser Leu Leu Lys Asp Thr Leu Ser Ala Tyr Ile Ser Ala 
    7730                7735                7740


Asp Asp Ile Ser Ile Leu Asn Glu Arg Val Glu Leu Leu Gln Arg Gln 
7745                7750                7755                7760


Trp Glu Glu Leu Cys His Gln Leu Ser Leu Arg Arg Gln Gln Ile Gly 
                7765                7770                7775


Glu Arg Leu Asn Glu Trp Ala Val Phe Ser Glu Lys Asn Lys Glu Leu 
            7780                7785                7790


Cys Glu Trp Leu Thr Gln Met Glu Ser Lys Val Ser Gln Asn Gly Asp 
        7795                7800                7805


Ile Leu Ile Glu Glu Met Ile Glu Lys Leu Lys Lys Asp Tyr Gln Glu 
    7810                7815                7820


Glu Ile Ala Ile Ala Gln Glu Asn Lys Ile Gln Leu Gln Gln Met Gly 
7825                7830                7835                7840


Glu Arg Leu Ala Lys Ala Ser His Glu Ser Lys Ala Ser Glu Ile Glu 
                7845                7850                7855


Tyr Lys Leu Gly Lys Val Asn Asp Arg Trp Gln His Leu Leu Asp Leu 
            7860                7865                7870


Ile Ala Ala Arg Val Lys Lys Leu Lys Glu Thr Leu Val Ala Val Gln 
        7875                7880                7885


Gln Leu Asp Lys Asn Met Ser Ser Leu Arg Thr Trp Leu Ala His Ile 
    7890                7895                7900


Glu Ser Glu Leu Ala Lys Pro Ile Val Tyr Asp Ser Cys Asn Ser Glu 
7905                7910                7915                7920


Glu Ile Gln Arg Lys Leu Asn Glu Gln Gln Glu Leu Gln Arg Asp Ile 
                7925                7930                7935


Glu Lys His Ser Thr Gly Val Ala Ser Val Leu Asn Leu Cys Glu Val 
            7940                7945                7950


Leu Leu His Asp Cys Asp Ala Cys Ala Thr Asp Ala Glu Cys Asp Ser 
        7955                7960                7965


Ile Gln Gln Ala Thr Arg Asn Leu Asp Arg Arg Trp Arg Asn Ile Cys 
    7970                7975                7980


Ala Met Ser Met Glu Arg Arg Leu Lys Ile Glu Glu Thr Trp Arg Leu 
7985                7990                7995                8000


Trp Gln Lys Phe Leu Asp Asp Tyr Ser Arg Phe Glu Asp Trp Leu Lys 
                8005                8010                8015


Ser Ser Glu Arg Thr Ala Ala Phe Pro Ser Ser Ser Gly Val Ile Tyr 
            8020                8025                8030


Thr Val Ala Lys Glu Glu Leu Lys Lys Phe Glu Ala Phe Gln Arg Gln 
        8035                8040                8045


Val His Glu Cys Leu Thr Gln Leu Glu Leu Ile Asn Lys Gln Tyr Arg 
    8050                8055                8060


Arg Leu Ala Arg Glu Asn Arg Thr Asp Ser Ala Cys Ser Leu Lys Gln 
8065                8070                8075                8080


Met Val His Glu Gly Asn Gln Arg Trp Asp Asn Leu Gln Lys Arg Val 
                8085                8090                8095


Thr Ser Ile Leu Arg Arg Leu Lys His Phe Ile Gly Gln Arg Glu Glu 
            8100                8105                8110


Phe Glu Thr Ala Arg Asp Ser Ile Leu Val Trp Leu Thr Glu Met Asp 
        8115                8120                8125


Leu Gln Leu Thr Asn Ile Glu His Phe Ser Glu Cys Asp Val Gln Ala 
    8130                8135                8140


Lys Ile Lys Gln Leu Lys Ala Phe Gln Gln Glu Ile Ser Leu Asn His 
8145                8150                8155                8160


Asn Lys Ile Glu Gln Ile Ile Ala Gln Gly Glu Gln Leu Ile Glu Lys 
                8165                8170                8175


Ser Glu Pro Leu Asp Ala Ala Ile Ile Glu Glu Glu Leu Asp Glu Leu 
            8180                8185                8190


Arg Arg Tyr Cys Gln Glu Val Phe Gly Arg Val Glu Arg Tyr His Lys 
        8195                8200                8205


Lys Leu Ile Arg Leu Pro Leu Pro Asp Asp Glu His Asp Leu Ser Asp 
    8210                8215                8220


Arg Glu Leu Glu Leu Glu Asp Ser Ala Ala Leu Ser Asp Leu His Trp 
8225                8230                8235                8240


His Asp Arg Ser Ala Asp Ser Leu Leu Ser Pro Gln Pro Ser Ser Asn 
                8245                8250                8255


Leu Ser Leu Ser Leu Ala Gln Pro Leu Arg Ser Glu Arg Ser Gly Arg 
            8260                8265                8270


Asp Thr Pro Ala Ser Val Asp Ser Ile Pro Leu Glu Trp Asp His Asp 
        8275                8280                8285


Tyr Asp Leu Ser Arg Asp Leu Glu Ser Ala Met Ser Arg Ala Leu Pro 
    8290                8295                8300


Ser Glu Asp Glu Glu Gly Gln Asp Asp Lys Asp Phe Tyr Leu Arg Gly 
8305                8310                8315                8320


Ala Val Gly Leu Ser Gly Asp His Ser Ala Leu Glu Ser Gln Ile Arg 
                8325                8330                8335


Gln Leu Gly Lys Ala Leu Asp Asp Ser Arg Phe Gln Ile Gln Gln Thr 
            8340                8345                8350


Glu Asn Ile Ile Arg Ser Lys Thr Pro Thr Gly Pro Glu Leu Asp Thr 
        8355                8360                8365


Ser Tyr Lys Gly Tyr Met Lys Leu Leu Gly Glu Cys Ser Ser Ser Ile 
    8370                8375                8380


Asp Ser Val Lys Arg Leu Glu His Lys Leu Lys Glu Glu Glu Glu Ser 
8385                8390                8395                8400


Leu Pro Gly Phe Val Asn Leu His Ser Thr Glu Thr Gln Thr Ala Gly 
                8405                8410                8415


Val Ile Asp Arg Trp Glu Leu Leu Gln Ala Gln Ala Leu Ser Lys Glu 
            8420                8425                8430


Leu Arg Met Lys Gln Asn Leu Gln Lys Trp Gln Gln Phe Asn Ser Asp 
        8435                8440                8445


Leu Asn Ser Ile Trp Ala Trp Leu Gly Asp Thr Glu Glu Glu Leu Glu 
    8450                8455                8460


Gln Leu Gln Arg Leu Glu Leu Ser Thr Asp Ile Gln Thr Ile Glu Leu 
8465                8470                8475                8480


Gln Ile Lys Lys Leu Lys Glu Leu Gln Lys Ala Val Asp His Arg Lys 
                8485                8490                8495


Ala Ile Ile Leu Ser Ile Asn Leu Cys Ser Pro Glu Phe Thr Gln Ala 
            8500                8505                8510


Asp Ser Lys Glu Ser Arg Asp Leu Gln Asp Arg Leu Ser Gln Met Asn 
        8515                8520                8525


Gly Arg Trp Asp Arg Val Cys Ser Leu Leu Glu Glu Trp Arg Gly Leu 
    8530                8535                8540


Leu Gln Asp Ala Leu Met Gln Cys Gln Gly Phe His Glu Met Ser His 
8545                8550                8555                8560


Gly Leu Leu Leu Met Leu Glu Asn Ile Asp Arg Arg Lys Asn Glu Ile 
                8565                8570                8575


Val Pro Ile Asp Ser Asn Leu Asp Ala Glu Ile Leu Gln Asp His His 
            8580                8585                8590


Lys Gln Leu Met Gln Ile Lys His Glu Leu Leu Glu Ser Gln Leu Arg 
        8595                8600                8605


Val Ala Ser Leu Gln Asp Met Ser Cys Gln Leu Leu Val Asn Ala Glu 
    8610                8615                8620


Gly Thr Asp Cys Leu Glu Ala Lys Glu Lys Val His Val Ile Gly Asn 
8625                8630                8635                8640


Arg Leu Lys Leu Leu Leu Lys Glu Val Ser Arg His Ile Lys Glu Leu 
                8645                8650                8655


Glu Lys Leu Leu Asp Val Ser Ser Ser Gln Gln Asp Leu Ser Ser Trp 
            8660                8665                8670


Ser Ser Ala Asp Glu Leu Asp Thr Ser Gly Ser Val Ser Pro Thr Ser 
        8675                8680                8685


Gly Arg Ser Thr Pro Asn Arg Gln Lys Thr Pro Arg Gly Lys Cys Ser 
    8690                8695                8700


Leu Ser Gln Pro Gly Pro Ser Val Ser Ser Pro His Ser Arg Ser Thr 
8705                8710                8715                8720


Lys Gly Gly Ser Asp Ser Ser Leu Ser Glu Pro Gly Pro Gly Arg Ser 
                8725                8730                8735


Gly Arg Gly Phe Leu Phe Arg Val Leu Arg Ala Ala Leu Pro Leu Gln 
            8740                8745                8750


Leu Leu Leu Leu Leu Leu Ile Gly Leu Ala Cys Leu Val Pro Met Ser 
        8755                8760                8765


Glu Glu Asp Tyr Ser Cys Ala Leu Ser Asn Asn Phe Ala Arg Ser Phe 
    8770                8775                8780


His Pro Met Leu Arg Tyr Thr Asn Gly Pro Pro Pro Leu 
8785                8790                8795


<210>  3422
<211>  7372
<212>  DNA
<213>  Homo sapiens

<400>  3422
aggagctgat agattccaga gagattggtg caagccgtct cagcagagtg gagtcgctgg     60

ctcccgaagt gaaacagaac acaactgcca gtgggtgtga gctcatgcac acggagatgc    120

aggccctgcg tgccgactgg aagcagtggg aagacagtgt attccaaacg cagagctgtt    180

tggagaacct ggtcagccag atggcccttt cggagcagga attctcaggc caagtggctc    240

aactggagca ggccctggaa cagttcagtg cccttctgaa aacctgggct cagcagttaa    300

ccctcctgga aggcaagaac acggatgagg agatagtgga atgctggcac aaaggacaag    360

agatactgga tgctttgcaa aaagcagagc ctagaacaga ggatctcaag tctcagctga    420

atgaactttg tcgattttcc agagacctga gtacctacag tggaaaagtt tctggcttga    480

ttaaagagta taattgtctt tgtttgcaag catccaaggg ctgccagaat aaagaacaga    540

ttttacagca aagatttcga aaggccttca gggatttcca gcagtggttg gttaatgcaa    600

aaatcactac cgccaagtgt tttgatatac ctcaaaatat aagtgaagtt tcaactagtc    660

ttcagaaaat acaggagttt ttgtcagaaa gtgaaaatgg acagcacaag ctaaacatga    720

tgctgtctaa aggggaactt ctgagtaccc tgctgaccaa agagaaagcg aaagggatcc    780

aggccaaagt tacagctgca aaagaagatt ggaaaaattt tcattcaaat ctccaccaaa    840

aagaatctgc tctagagaat ctaaagatcc aaatgaagga ctttgaagta agtgctgagc    900

ctatccagga ctggctgagt aaaactgaga agatggtcca tgaaagcagc aatcgcctct    960

atgatctgcc agcaaagagg agggagcagc agaagctcca ggtgatgagc ccgcctcccc   1020

gtagccccat ctgacctagt ctttgtccgt cctctgtcga ccttacagat gcatgctcag   1080

cacccttgag ttagactgtg ctgccgtgag acatagtgtg tttttcccca tttctggtgg   1140

attttatgtt ttctgacttt ccttggaagt atgatttgtt tccttccatg atttgtgctc   1200

cacggtgtgt agattggaga taataaagcc tccagggtac acggactgcc tgccagtgtt   1260

gatttccatg ttctctgggc caaagcttcg tccgcgatgt gcttttcccc agcctctgaa   1320

tagtaacttg cttgtgcttt tcagtctgtc cttgaggaaa tacactgcta cgagcctcag   1380

ctcaacaggc tgaaagagaa agctcagcag ctgtgggaag gacaagctgc cagcaagagc   1440

tttaggcaca gagtgtcgca gctgtcttct cagtatctag cgctaagcaa tttaacaaag   1500

gtaacgcctg gcacgtgctg tgtgtgagtg tgatactgat gtcgcaaaat tggagttgca   1560

gcaggttctg cagggtgtgc attgcatcct gacccgccca cagtgtgggt ctccaggtca   1620

gcagtaaggg gcgtgtgtgc tgtttcctta gccttgcaat ctgagttcat cattgttgtt   1680

gcataagctt gatgtggctc tctgaaaagg ccgaaggagg tttcaaagat tgaggagact   1740

ttcagtcttc attattgcac aagatattcc ttttaatact gaaatgatat gtttcccagg   1800

gctttgattt ggaagactca aatcataaac atgatttttt ttgttctaaa taatcccaga   1860

gtttttgttc taaataatcc cagattaaat tactttagaa aaaacatgga ttctaaacag   1920

tttaaatttt attagattaa atataatgat atttttaaaa aattcatctg aatctttgca   1980

ttcattatat agtagtcaag gatgtgttga ttgagagttt cagttcagat tctagagcag   2040

agctcaaaat tggcaatggt tcagacaact gattaaacct cttttcaaat agcttagaag   2100

aaaataaatg gaatcctact acaatctcat ttagaacatt cagccatttt gacgtagatg   2160

gtaacgtaga cccattttga actgtgtgtt gcagacctat cttgagcttt atgtggctta   2220

taacctttgt ttcctatgtt tttaactttc aggtgttaga atatagggac actggtataa   2280

tttagtcttt aatttggcct catctgttct gtaagtgtgc atttacagag ggtctgctca   2340

tttgggtctt caatacacat cactgaagca gtcacactag cttaggtctg ggagtaaata   2400

gtctatgttt acacccattt ttattctatg attgttattt tggatgtttt tataaaatct   2460

ggcacatacc taagttaaga taaggaatga atcatcttag aatgaatgaa gaacatcttt   2520

ccattccttt gtatttactt agataccaaa agtaatcgat atatgaatat tttgagagct   2580

gtagattatt cttgcaaagt cttcactgtg ttagatataa cctataattg ataaacaaaa   2640

ccatgtgtat ggtcccatgt tttaaaattt agagatatta caaaaatctc agattatttt   2700

ttttttagaa ctctggctac aatgtaggtc atgtgggttg ttgtgtcagg tgagcctaat   2760

gtgatatgtg aaaactagaa actactttga ccagtctccc agacaaggca ttagggagaa   2820

attttactga tttaaaataa tcatgatagt cataaagaat tggagaggca taaaattgta   2880

actttttttt ttgcttttga cccagttatt ctaatagttt tatgatttag aaagatcttt   2940

aacatatctc atagatttag gccagacttg cctcgtatct gtgcagcgta tgaagccatg   3000

actgattgcc tttgtttcaa acaaactgtt agctttgcag tttgtctctg tgggatggac   3060

agctcgaaaa ccatttctgt catttccagg agaaagtgtc aagactggat agaatcgttg   3120

cagaacacaa tcagttctct cttgggatta aagaattaca agactggatg acggatgcga   3180

ttcacatgct ggattcatac tgccacccga catccgacaa aagtgtgctg gacagcagga   3240

cgctcaagct cgaggctcta ttatcagtca aacaggaaaa agagattcag atgaaaatga   3300

tagtgaccag gggagaatct gtccttcaga atacttctcc agaaggcatt cccactattc   3360

agcagcagct gcagagtgtg aaggatatgt gggcatccct tttgtctgca gggattcgtt   3420

gtaaaagcca actcgaagga gctctctcca agtggacaag ttatcaggat ggcgttcgac   3480

agttctccgg ttggatggat agtatggaag ccaacctgaa tgaatcagaa aggcagcatg   3540

cggagctgcg ggataaaaca acgatgctcg gaaaagccaa gttattaaat gaagaagtgc   3600

tgagttacag cagcttgctg gagaccatcg aagtcaaagg ggctggcatg acagaacact   3660

atgtcaccca gctagaactc caggatctac aggaacgata cagagccatc caagagaggg   3720

ccaaggaagc cgtaaccaag tctgaaaaac ttgtccgcct gcaccaagag tatcagagag   3780

acctaaaggc atttgaagtt tggttggggc aagaacaaga aaagctcgac cagtattcag   3840

ttcttgaagg tgatgcccac actcatgaga caacattgcg tgatcttcag gagctacagg   3900

tacactgtgc agaggggcag gccctgttga actcagtgct gcacaccaga gaggatgtga   3960

tcccatcagg tatcccacag gcagaggacc gggctttaga gtctctccgg caagactggc   4020

aggcttacca gcacaggctg tccgagactc gaactcagtt caataacgtg gtgaacaaat   4080

tgaggctaat ggagcaaaag tttcagcaag tagatgaatg gctcaaaaca gcagaggaga   4140

aagttagtcc caggaccaga cgtcagtcta acagggcaac caaggagata caattacatc   4200

agatgaagaa gtggcacgaa gaagtgactg catacagaga tgaagttgag gaagtgggag   4260

ctagagctca ggagatactg gacgagagcc acgtgaacag cagaatgggt tgccaggcca   4320

cccagctgac ttccagatac caggccctgc ttctccaagt gctggaacaa ataaaattcc   4380

tggaggagga gattcagagt ttggaggaat cagaatcatc cctcagttcc tattctgatt   4440

ggtatggctc tactcataaa aacttcaaga atgtggctac caagattgac aaagtagata   4500

cagtaatgat ggggaagaaa ttgaagacgt tggaggtttt gctcaaagac atggagaaag   4560

gtcacagttt gctgaaatca gcccgggaga aaggagagag ggctgttaaa tacttggagg   4620

aaggcgaggc agagaggtta agaaaggaga ttcatgatca catggagcag ttgaaggaac   4680

tgaccagcac tgtccggaaa gaacacatga cgctggaaaa aggtcttcat ttagcaaagg   4740

aattctcaga taaatgcaaa gcactgacac agtggatagc agaataccag gaaattctac   4800

atgttcctga agaacccaaa atggaattat atgagaaaaa agctcagtta tctaaataca   4860

agtcacttca acaaacggtg ctgtcccatg aaccatcagt aaagtcagtg agagagaagg   4920

gtgaagctct tttggaactg gtgcaggacg tcactttaaa ggacaaaata gatcaacttc   4980

aaagtgatta ccaggacctg tgcagcatag gaaaggagca tgtcttcagt ctggaggcga   5040

aagtcaaaga ccatgaagac tacaacagtg agctccaaga ggtcgaaaag tggctgctgc   5100

agatgtctgg cagactggtg gcacctgacc tcctggagac aagcagcctg gagacaatca   5160

cccagcaatt ggcccaccac aaggcaatga tggaagaaat tgctggtttt gaagaccgtt   5220

tgaacaatct tcaaatgaaa ggtgatactt tgattggcca atgtgcagac cacctgcaag   5280

cgaaacttaa acaaaacgtg catgctcatc tgcagggcac aaaggacagc tactcagcga   5340

tctgcagcac agctcagagg atgtaccaga gtttggaaca cgaacttcag aagcacgtca   5400

gccgacaaga caccctgcag cagtgccagg cctggctttc tgcagtccag ccggatttag   5460

agccaagtcc tcaaccacct cttagtaggg cagaagccat taagcaggtc aaacacttca   5520

gagctttgca agagcaggca aggacctacc tagatctcct ttgctccatg tgtgacctgt   5580

caaatgcttc ggtgaaaacc acagcaaaag acattcaaca aacagagcaa acgattgaac   5640

aaaagcttgt ccaggcccag aacttaactc agggctggga agagatcaag cacctgaagt   5700

ctgagctctg gatttacctg caagatgctg atcagcaact gcagaacatg aagaggaggc   5760

actctgagct ggagctgaac attgcacaga acatggtttc acaagttaag gtgggaatta   5820

atttgccccc aagggagata aaagaggcca acagagtaga aaacctgaaa tgtgttcagt   5880

gtattcactt caatatgcct gagtgtctgt caatccttag acattaatac aactctttaa   5940

ggcagaggtc cccaagcccc aggttatgga caagcacaag tccatgtcct gttaggaacc   6000

tggccgcaca gtgggaggcg agcaagcatt aatgcctgaa ctccacctcc tgtcagatca   6060

gaggccacat cagattctca taggagtgca aaccctactg tgaactgcgc atgcaaggga   6120

tctaggttgc atgctcctta tgataatcta actaatatct gatgatttga ggtggaacag   6180

cttcatcctg aaaccatccc cctccagccc cattcacgga aaaattgttt tccacaaaac   6240

ccatcccagg tgccaaaaag tttggggacc gctgctttaa ggaatagcaa atctgaacaa   6300

acatcatttg gtgccaggga aaacagatta taaagtagac attcaaatat attactgaag   6360

cttcagatgg ccactttcat cagaagacat tcatactcta cattattcct gagaaaagca   6420

ggtgtgattt agtctacaga gtagactgct tagtcagaaa actctgtgac taagcaaaca   6480

tggaacatta ttcttttttt agattttcat caccatatta tgctaaaact gtaggactgt   6540

aagcttatca attcattagt tatatatttg agctatatgt aattaattta aagtataata   6600

taaatgcagt ttgtattaca tatttatata taatttaaat aatttaaaat atataggaaa   6660

ttgtggccgg gtgtggtggc tcatgcctgt aatcccagca ctttgggaag ctgaggtggg   6720

cagatcactt gaggccagga gtttgagacc aggctggcca acatggtgag accacatctc   6780

tattaaaaat acaaaaatta gccttgcgtg gcacatgcct ataatctcag ctacttggga   6840

ggctgaggca cgagaatcat ttgaacttgg gaggcggagg ttgcagtgag ccatgatcat   6900

gccactgcac tccagcctgg gccacagagt gagactctgt ctcaaaaaaa agggaaaaaa   6960

gaaaattata agtgtattaa cttaattgga agttgggtca gattttaaat aaacttaaag   7020

atgttttttc tctgtgatta tgagtcaata ataatatatt gtctactgga gtgctgtttg   7080

caagtacaga gaaaaaagag aatagggatc gggataataa gatttatttt ttctcagaag   7140

catgaactct tttttaaaaa aatttgtgaa ccatcctaga aatttaattt tttaaaatgt   7200

attttataag aaaagttttg tttattataa aaggcttaga aaatacagaa atgtcttaat   7260

aagcaaattt aaatcacaat cacttatgat actaccattc agagataata aacaatgcca   7320

atattttgct gtatttgttt tagatataca cataataaaa acattcaaga tg           7372


<210>  3423
<211>  919
<212>  PRT
<213>  Homo sapiens

<400>  3423

Met Thr Asp Ala Ile His Met Leu Asp Ser Tyr Cys His Pro Thr Ser 
1               5                   10                  15


Asp Lys Ser Val Leu Asp Ser Arg Thr Leu Lys Leu Glu Ala Leu Leu 
            20                  25                  30


Ser Val Lys Gln Glu Lys Glu Ile Gln Met Lys Met Ile Val Thr Arg 
        35                  40                  45


Gly Glu Ser Val Leu Gln Asn Thr Ser Pro Glu Gly Ile Pro Thr Ile 
    50                  55                  60


Gln Gln Gln Leu Gln Ser Val Lys Asp Met Trp Ala Ser Leu Leu Ser 
65                  70                  75                  80


Ala Gly Ile Arg Cys Lys Ser Gln Leu Glu Gly Ala Leu Ser Lys Trp 
                85                  90                  95


Thr Ser Tyr Gln Asp Gly Val Arg Gln Phe Ser Gly Trp Met Asp Ser 
            100                 105                 110


Met Glu Ala Asn Leu Asn Glu Ser Glu Arg Gln His Ala Glu Leu Arg 
        115                 120                 125


Asp Lys Thr Thr Met Leu Gly Lys Ala Lys Leu Leu Asn Glu Glu Val 
    130                 135                 140


Leu Ser Tyr Ser Ser Leu Leu Glu Thr Ile Glu Val Lys Gly Ala Gly 
145                 150                 155                 160


Met Thr Glu His Tyr Val Thr Gln Leu Glu Leu Gln Asp Leu Gln Glu 
                165                 170                 175


Arg Tyr Arg Ala Ile Gln Glu Arg Ala Lys Glu Ala Val Thr Lys Ser 
            180                 185                 190


Glu Lys Leu Val Arg Leu His Gln Glu Tyr Gln Arg Asp Leu Lys Ala 
        195                 200                 205


Phe Glu Val Trp Leu Gly Gln Glu Gln Glu Lys Leu Asp Gln Tyr Ser 
    210                 215                 220


Val Leu Glu Gly Asp Ala His Thr His Glu Thr Thr Leu Arg Asp Leu 
225                 230                 235                 240


Gln Glu Leu Gln Val His Cys Ala Glu Gly Gln Ala Leu Leu Asn Ser 
                245                 250                 255


Val Leu His Thr Arg Glu Asp Val Ile Pro Ser Gly Ile Pro Gln Ala 
            260                 265                 270


Glu Asp Arg Ala Leu Glu Ser Leu Arg Gln Asp Trp Gln Ala Tyr Gln 
        275                 280                 285


His Arg Leu Ser Glu Thr Arg Thr Gln Phe Asn Asn Val Val Asn Lys 
    290                 295                 300


Leu Arg Leu Met Glu Gln Lys Phe Gln Gln Val Asp Glu Trp Leu Lys 
305                 310                 315                 320


Thr Ala Glu Glu Lys Val Ser Pro Arg Thr Arg Arg Gln Ser Asn Arg 
                325                 330                 335


Ala Thr Lys Glu Ile Gln Leu His Gln Met Lys Lys Trp His Glu Glu 
            340                 345                 350


Val Thr Ala Tyr Arg Asp Glu Val Glu Glu Val Gly Ala Arg Ala Gln 
        355                 360                 365


Glu Ile Leu Asp Glu Ser His Val Asn Ser Arg Met Gly Cys Gln Ala 
    370                 375                 380


Thr Gln Leu Thr Ser Arg Tyr Gln Ala Leu Leu Leu Gln Val Leu Glu 
385                 390                 395                 400


Gln Ile Lys Phe Leu Glu Glu Glu Ile Gln Ser Leu Glu Glu Ser Glu 
                405                 410                 415


Ser Ser Leu Ser Ser Tyr Ser Asp Trp Tyr Gly Ser Thr His Lys Asn 
            420                 425                 430


Phe Lys Asn Val Ala Thr Lys Ile Asp Lys Val Asp Thr Val Met Met 
        435                 440                 445


Gly Lys Lys Leu Lys Thr Leu Glu Val Leu Leu Lys Asp Met Glu Lys 
    450                 455                 460


Gly His Ser Leu Leu Lys Ser Ala Arg Glu Lys Gly Glu Arg Ala Val 
465                 470                 475                 480


Lys Tyr Leu Glu Glu Gly Glu Ala Glu Arg Leu Arg Lys Glu Ile His 
                485                 490                 495


Asp His Met Glu Gln Leu Lys Glu Leu Thr Ser Thr Val Arg Lys Glu 
            500                 505                 510


His Met Thr Leu Glu Lys Gly Leu His Leu Ala Lys Glu Phe Ser Asp 
        515                 520                 525


Lys Cys Lys Ala Leu Thr Gln Trp Ile Ala Glu Tyr Gln Glu Ile Leu 
    530                 535                 540


His Val Pro Glu Glu Pro Lys Met Glu Leu Tyr Glu Lys Lys Ala Gln 
545                 550                 555                 560


Leu Ser Lys Tyr Lys Ser Leu Gln Gln Thr Val Leu Ser His Glu Pro 
                565                 570                 575


Ser Val Lys Ser Val Arg Glu Lys Gly Glu Ala Leu Leu Glu Leu Val 
            580                 585                 590


Gln Asp Val Thr Leu Lys Asp Lys Ile Asp Gln Leu Gln Ser Asp Tyr 
        595                 600                 605


Gln Asp Leu Cys Ser Ile Gly Lys Glu His Val Phe Ser Leu Glu Ala 
    610                 615                 620


Lys Val Lys Asp His Glu Asp Tyr Asn Ser Glu Leu Gln Glu Val Glu 
625                 630                 635                 640


Lys Trp Leu Leu Gln Met Ser Gly Arg Leu Val Ala Pro Asp Leu Leu 
                645                 650                 655


Glu Thr Ser Ser Leu Glu Thr Ile Thr Gln Gln Leu Ala His His Lys 
            660                 665                 670


Ala Met Met Glu Glu Ile Ala Gly Phe Glu Asp Arg Leu Asn Asn Leu 
        675                 680                 685


Gln Met Lys Gly Asp Thr Leu Ile Gly Gln Cys Ala Asp His Leu Gln 
    690                 695                 700


Ala Lys Leu Lys Gln Asn Val His Ala His Leu Gln Gly Thr Lys Asp 
705                 710                 715                 720


Ser Tyr Ser Ala Ile Cys Ser Thr Ala Gln Arg Met Tyr Gln Ser Leu 
                725                 730                 735


Glu His Glu Leu Gln Lys His Val Ser Arg Gln Asp Thr Leu Gln Gln 
            740                 745                 750


Cys Gln Ala Trp Leu Ser Ala Val Gln Pro Asp Leu Glu Pro Ser Pro 
        755                 760                 765


Gln Pro Pro Leu Ser Arg Ala Glu Ala Ile Lys Gln Val Lys His Phe 
    770                 775                 780


Arg Ala Leu Gln Glu Gln Ala Arg Thr Tyr Leu Asp Leu Leu Cys Ser 
785                 790                 795                 800


Met Cys Asp Leu Ser Asn Ala Ser Val Lys Thr Thr Ala Lys Asp Ile 
                805                 810                 815


Gln Gln Thr Glu Gln Thr Ile Glu Gln Lys Leu Val Gln Ala Gln Asn 
            820                 825                 830


Leu Thr Gln Gly Trp Glu Glu Ile Lys His Leu Lys Ser Glu Leu Trp 
        835                 840                 845


Ile Tyr Leu Gln Asp Ala Asp Gln Gln Leu Gln Asn Met Lys Arg Arg 
    850                 855                 860


His Ser Glu Leu Glu Leu Asn Ile Ala Gln Asn Met Val Ser Gln Val 
865                 870                 875                 880


Lys Val Gly Ile Asn Leu Pro Pro Arg Glu Ile Lys Glu Ala Asn Arg 
                885                 890                 895


Val Glu Asn Leu Lys Cys Val Gln Cys Ile His Phe Asn Met Pro Glu 
            900                 905                 910


Cys Leu Ser Ile Leu Arg His 
        915


<210>  3424
<211>  1547
<212>  DNA
<213>  Homo sapiens

<400>  3424
aggagctgat agattccaga gagattggtg caagccgtct cagcagagtg gagtcgctgg     60

ctcccgaagt gaaacagaac acaactgcca gtgggtgtga gctcatgcac acggagatgc    120

aggccctgcg tgccgactgg aagcagtggg aagacagtgt attccaaacg cagagctgtt    180

tggagaacct ggtcagccag atggcccttt cggagcagga attctcaggc caagtggctc    240

aactggagca ggccctggaa cagttcagtg cccttctgaa aacctgggct cagcagttaa    300

ccctcctgga aggcaagaac acggatgagg agatagtgga atgctggcac aaaggacaag    360

agatactgga tgctttgcaa aaagcagagc ctagaacaga ggatctcaag tctcagctga    420

atgaactttg tcgattttcc agagacctga gtacctacag tggaaaagtt tctggcttga    480

ttaaagagta taattgtctt tgtttgcaag catccaaggg ctgccagaat aaagaacaga    540

ttttacagca aagatttcga aaggccttca gggatttcca gcagtggttg gttaatgcaa    600

aaatcactac cgccaagtgt tttgatatac ctcaaaatat aagtgaagtt tcaactagtc    660

ttcagaaaat acaggagttt ttgtcagaaa gtgaaaatgg acagcacaag ctaaacatga    720

tgctgtctaa aggggaactt ctgagtaccc tgctgaccaa agagaaagcg aaagggatcc    780

aggccaaagt tacagctgca aaagaagatt ggaaaaattt tcattcaaat ctccaccaaa    840

aagaatctgc tctagagaat ctaaagatcc aaatgaagga ctttgaagta agtgctgagc    900

ctatccagga ctggctgagt aaaactgaga agatggtcca tgaaagcagc aatcgcctct    960

atgatctgcc agcaaagagg agggagcagc agaagctcca gtctgtcctt gaggaaatac   1020

actgctacga gcctcagctc aacaggctga aagagaaagc tcagcagctg tgggaaggac   1080

aagctgccag caagagcttt aggcacagag tgtcgcagct gtcttctcag tatctagcgc   1140

taagcaattt aacaaaggag aaagtgtcaa gactggatag aatcgttgca gaacacaatc   1200

agttctctct tgggattaaa gaattacaag actggatgac ggatgcgatt cacatgctgg   1260

attcatactg ccacccgaca tccgacaaaa gtgtgctgga cagcaggacg ctcaagctcg   1320

aggtgtgcat ctttacacag aaatatctcc aacctacaga atttgttttt ctcaaaattt   1380

cccgtctcca tccacctggg gtgatgatgt cacattctct ccatgataaa tctcagatgc   1440

tttgtgagtg caacgctgtc tgccttgggt gcacatgcca gagaattcct gaatcatctg   1500

accccggatg ttttccaaaa aataaaataa aataaagccc gaatgtg                 1547


<210>  3425
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  3425

Met His Thr Glu Met Gln Ala Leu Arg Ala Asp Trp Lys Gln Trp Glu 
1               5                   10                  15


Asp Ser Val Phe Gln Thr Gln Ser Cys Leu Glu Asn Leu Val Ser Gln 
            20                  25                  30


Met Ala Leu Ser Glu Gln Glu Phe Ser Gly Gln Val Ala Gln Leu Glu 
        35                  40                  45


Gln Ala Leu Glu Gln Phe Ser Ala Leu Leu Lys Thr Trp Ala Gln Gln 
    50                  55                  60


Leu Thr Leu Leu Glu Gly Lys Asn Thr Asp Glu Glu Ile Val Glu Cys 
65                  70                  75                  80


Trp His Lys Gly Gln Glu Ile Leu Asp Ala Leu Gln Lys Ala Glu Pro 
                85                  90                  95


Arg Thr Glu Asp Leu Lys Ser Gln Leu Asn Glu Leu Cys Arg Phe Ser 
            100                 105                 110


Arg Asp Leu Ser Thr Tyr Ser Gly Lys Val Ser Gly Leu Ile Lys Glu 
        115                 120                 125


Tyr Asn Cys Leu Cys Leu Gln Ala Ser Lys Gly Cys Gln Asn Lys Glu 
    130                 135                 140


Gln Ile Leu Gln Gln Arg Phe Arg Lys Ala Phe Arg Asp Phe Gln Gln 
145                 150                 155                 160


Trp Leu Val Asn Ala Lys Ile Thr Thr Ala Lys Cys Phe Asp Ile Pro 
                165                 170                 175


Gln Asn Ile Ser Glu Val Ser Thr Ser Leu Gln Lys Ile Gln Glu Phe 
            180                 185                 190


Leu Ser Glu Ser Glu Asn Gly Gln His Lys Leu Asn Met Met Leu Ser 
        195                 200                 205


Lys Gly Glu Leu Leu Ser Thr Leu Leu Thr Lys Glu Lys Ala Lys Gly 
    210                 215                 220


Ile Gln Ala Lys Val Thr Ala Ala Lys Glu Asp Trp Lys Asn Phe His 
225                 230                 235                 240


Ser Asn Leu His Gln Lys Glu Ser Ala Leu Glu Asn Leu Lys Ile Gln 
                245                 250                 255


Met Lys Asp Phe Glu Val Ser Ala Glu Pro Ile Gln Asp Trp Leu Ser 
            260                 265                 270


Lys Thr Glu Lys Met Val His Glu Ser Ser Asn Arg Leu Tyr Asp Leu 
        275                 280                 285


Pro Ala Lys Arg Arg Glu Gln Gln Lys Leu Gln Ser Val Leu Glu Glu 
    290                 295                 300


Ile His Cys Tyr Glu Pro Gln Leu Asn Arg Leu Lys Glu Lys Ala Gln 
305                 310                 315                 320


Gln Leu Trp Glu Gly Gln Ala Ala Ser Lys Ser Phe Arg His Arg Val 
                325                 330                 335


Ser Gln Leu Ser Ser Gln Tyr Leu Ala Leu Ser Asn Leu Thr Lys Glu 
            340                 345                 350


Lys Val Ser Arg Leu Asp Arg Ile Val Ala Glu His Asn Gln Phe Ser 
        355                 360                 365


Leu Gly Ile Lys Glu Leu Gln Asp Trp Met Thr Asp Ala Ile His Met 
    370                 375                 380


Leu Asp Ser Tyr Cys His Pro Thr Ser Asp Lys Ser Val Leu Asp Ser 
385                 390                 395                 400


Arg Thr Leu Lys Leu Glu Val Cys Ile Phe Thr Gln Lys Tyr Leu Gln 
                405                 410                 415


Pro Thr Glu Phe Val Phe Leu Lys Ile Ser Arg Leu His Pro Pro Gly 
            420                 425                 430


Val Met Met Ser His Ser Leu His Asp Lys Ser Gln Met Leu Cys Glu 
        435                 440                 445


Cys Asn Ala Val Cys Leu Gly Cys Thr Cys Gln Arg Ile Pro Glu Ser 
    450                 455                 460


Ser Asp Pro Gly Cys Phe Pro Lys Asn Lys Ile Lys 
465                 470                 475


<210>  3426
<211>  715
<212>  DNA
<213>  Homo sapiens

<400>  3426
aaaaccacac agaggagagc taatcgggga gataactatt tgctgtgctg taggagatta     60

ccaagagggt taactgctga gcccaggttt tcagaagggc actgaactgt tccagggcct    120

gctccagttg agccacttgg cctgagaatt cctgctccga aagggccatc tggctgacca    180

ggttctccaa acagctctgc gtttggaata cactgtcttc ccactgcttc cagtcggcac    240

gcagggcctg catctccgtg tgcatgagct cacacccact ggcagttgtg ttctgtttca    300

cttcgggagc cagcgactcc actctgctga gacggcttgc accaatctct ctggaatcta    360

tcagctcctg taatggaata tcaccatggt aactgaagag cctgtgagtc acttggactg    420

caagttttca actgtgtaca cagggggacc ctgtcctgcc aggaagtttt aacaagtgtg    480

ccacaaggac ccagaatcaa ttcatctgtc cactcttaaa ttataatagc gggagttgtc    540

atcacgagtg cctaaggctt atggcaaaaa aatcccgaga atcctcaata tcctgaaaca    600

gactaaacag agaccctgaa atcaggcatt attcgcacac gtgaaaatgt ttagtgactc    660

aagtgtttgc ctgtggtgga ttgctcctgt gaatgattaa acccatattt ccctc         715


<210>  3427
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  3427

Met Ser Ser His Pro Leu Ala Val Val Phe Cys Phe Thr Ser Gly Ala 
1               5                   10                  15


Ser Asp Ser Thr Leu Leu Arg Arg Leu Ala Pro Ile Ser Leu Glu Ser 
            20                  25                  30


Ile Ser Ser Cys Asn Gly Ile Ser Pro Trp 
        35                  40


<210>  3428
<211>  617
<212>  DNA
<213>  Homo sapiens

<400>  3428
atttcttaga gacaaatggt tttaaactca tgacttatca ctgactattt tattaattaa     60

gaaatcattt atccacagca tgaaactgcc aagaacaaaa tgaattacaa acagaaagac    120

ttggataact ttaccagcaa aggaaaacac ttgttatctg agctgaagaa aattcacagt    180

agtgatttca gcttggtgaa aacagacatg gagagcaccg tggacaaatg gctggatgta    240

tcagagaaac ttgaagaaaa catggatagg ctgagagtaa gcctgtccat ttgggatgat    300

gtactgtcaa ctagagatga gattgaggga tggtcaaaca actgcgttcc acagatggca    360

gaaaacatca gcaacctgga taaccacctc agagctgaag aactgcttaa agaatttgag    420

tctgaagtta aaaacaaagc attgagattg gaagaactgc attccaaagt taatgatctg    480

aaagaattaa ctaaaaatct agaaacaccg ccagaccttc agtttataga agcagactta    540

atgcagaaac tggagcatgc caaagaaata actgaagtag caaaaggaac cctgaaggat    600

ttcacggctc aaagtac                                                   617


<210>  3429
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  3429

Met Asn Tyr Lys Gln Lys Asp Leu Asp Asn Phe Thr Ser Lys Gly Lys 
1               5                   10                  15


His Leu Leu Ser Glu Leu Lys Lys Ile His Ser Ser Asp Phe Ser Leu 
            20                  25                  30


Val Lys Thr Asp Met Glu Ser Thr Val Asp Lys Trp Leu Asp Val Ser 
        35                  40                  45


Glu Lys Leu Glu Glu Asn Met Asp Arg Leu Arg Val Ser Leu Ser Ile 
    50                  55                  60


Trp Asp Asp Val Leu Ser Thr Arg Asp Glu Ile Glu Gly Trp Ser Asn 
65                  70                  75                  80


Asn Cys Val Pro Gln Met Ala Glu Asn Ile Ser Asn Leu Asp Asn His 
                85                  90                  95


Leu Arg Ala Glu Glu Leu Leu Lys Glu Phe Glu Ser Glu Val Lys Asn 
            100                 105                 110


Lys Ala Leu Arg Leu Glu Glu Leu His Ser Lys Val Asn Asp Leu Lys 
        115                 120                 125


Glu Leu Thr Lys Asn Leu Glu Thr Pro Pro Asp Leu Gln Phe Ile Glu 
    130                 135                 140


Ala Asp Leu Met Gln Lys Leu Glu His Ala Lys Glu Ile Thr Glu Val 
145                 150                 155                 160


Ala Lys Gly Thr Leu Lys Asp Phe Thr Ala Gln 
                165                 170


<210>  3430
<211>  381
<212>  DNA
<213>  Homo sapiens

<400>  3430
tatcctcata tggtggtctc ttcctttctt ttcctctcct ggttcatatt tgggccagag     60

tgacctctgg catttacctc caactaactt tgaggtgcag gaccccacaa gccatcattt    120

atcctttggc aaatatagca gcagttagcc agcctgtctg tcacttttag gattctttgg    180

gggatagaga tcagactccc atgcctgcca aatgcagggg acaaatatcc tgttcttcag    240

gtggcactgc cggaaccctt ctgccttgag taacataaag aagaggaaag aagatcaaag    300

aattatgaaa caaatgagat gcttgtaaac ttcattagtt atatgaaacc acaaaggggc    360

atttaataaa ctattcctct c                                              381


<210>  3431
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  3431

Met Gln Gly Thr Asn Ile Leu Phe Phe Arg Trp His Cys Arg Asn Pro 
1               5                   10                  15


Ser Ala Leu Ser Asn Ile Lys Lys Arg Lys Glu Asp Gln Arg Ile Met 
            20                  25                  30


Lys Gln Met Arg Cys Leu 
        35


<210>  3432
<211>  1801
<212>  DNA
<213>  Homo sapiens

<400>  3432
agttccagca tagtgtttta agtacaagca cccagctcct attcaaggat ctgcttcaaa     60

acacggatgc ccacaaaaga gcattccatg aaatctaccg gaccaggtct gttaacggga    120

ttccagtgcc acctgatcaa ttagaggaca tggccgagag agtcaaagct gaagtcttgg    180

atcattaagt acgggaggag agagtcagtg gagcagcttc tacaaaacta cgtgtctttt    240

atagaaaata gcaagttctt tgaacaatat gaggtgacat accagatctt gaaacagaca    300

gctgagatgt atgtcaaagc agatggttca gtggaagaag ctgagaatgt gatgaaattc    360

atgaatgaaa ccaccgctca gtggaggaat ctctcagtag aagtgaggag tgtgaggagc    420

atgctggaag aagtgatctc taactgggat cgctatggca atacagtggc tagtctgcaa    480

gcctggctag aggatgctga aaaaatgctc aatcaatcag aaaatgccaa aaaggatttt    540

tttcgaaatt tacctcattg gattcagcag catactgcca tgaacgatgc tggcaatttt    600

ctaattgaaa cctgtgatga gatggtttcc cgtgacctga agcagcaatt actgttgcta    660

aatgggcggt ggagggagtt gtttatggaa gtcaagcaat atgctcaagc tgatgagatg    720

gacagaatga agaaggaata cacagactgt gttgttaccc tgtctgcttt tgcaacggaa    780

gcccataaga aactttctga acccttagaa gtctctttta tgaatgtcaa gctattaatt    840

caagacttgg aggatattga gcagagggtg cctgtgatgg atgcccaata caagataatt    900

acaaagacag cacacctcat taccaaagaa agcccccaag aagaaggaaa agaaatgttt    960

gcgaccatgt caaagctcaa agagcagcta accaaggtca aagaatgtta ctccccactc   1020

ctttatgagt ctcagcagct gttgattccg ttggaggaat tagaaaagca gatgacgtcc   1080

ttttatgact cacttgggaa aatcaatgaa attatcacag ttcttgagcg tgaggcacaa   1140

tcgagtgccc tttttaaaca aaaacatcag gaactgttag cttgtcaaga aaactgtaag   1200

aaaaccttga cacttattga gaaaggcagt caaagtgttc aaaagtttgt gaccttgagc   1260

aacgtgttaa agcattttga tcagacgagg ctacaaagac agattgcaga tattcatgtt   1320

gcttttcaga gtatggtaaa gaaaactgga gattggaaga agcatgtgga aaccaacagt   1380

cgcttgatga agaagtttga ggagtctcga gcagagttgg agaaggtact gcggattgct   1440

caggagggcc tggaggaaaa gggggatcca gaggagctcc tgcggagaca cactgagttt   1500

ttcagtcagc tggatcagag ggtgctcaat gctttcctga aagcttgtga tgaactcacc   1560

gacatccttc cagagcagga gcagcagggg ctgcaggaag ctgttcgaaa gctccacaaa   1620

caatggaagg tgagtcagga caggacggag acaccgtgca tcctcaatga agggagaagc   1680

ttgagcgtgt taaggtccaa atgtaagaga aatttagaaa ttcctggaaa gtcactgtaa   1740

ctatttcgct catttaaaaa ctcaaaaaac tggacttaaa taaaacctga taatatatga   1800

t                                                                   1801


<210>  3433
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  3433

Met Tyr Val Lys Ala Asp Gly Ser Val Glu Glu Ala Glu Asn Val Met 
1               5                   10                  15


Lys Phe Met Asn Glu Thr Thr Ala Gln Trp Arg Asn Leu Ser Val Glu 
            20                  25                  30


Val Arg Ser Val Arg Ser Met Leu Glu Glu Val Ile Ser Asn Trp Asp 
        35                  40                  45


Arg Tyr Gly Asn Thr Val Ala Ser Leu Gln Ala Trp Leu Glu Asp Ala 
    50                  55                  60


Glu Lys Met Leu Asn Gln Ser Glu Asn Ala Lys Lys Asp Phe Phe Arg 
65                  70                  75                  80


Asn Leu Pro His Trp Ile Gln Gln His Thr Ala Met Asn Asp Ala Gly 
                85                  90                  95


Asn Phe Leu Ile Glu Thr Cys Asp Glu Met Val Ser Arg Asp Leu Lys 
            100                 105                 110


Gln Gln Leu Leu Leu Leu Asn Gly Arg Trp Arg Glu Leu Phe Met Glu 
        115                 120                 125


Val Lys Gln Tyr Ala Gln Ala Asp Glu Met Asp Arg Met Lys Lys Glu 
    130                 135                 140


Tyr Thr Asp Cys Val Val Thr Leu Ser Ala Phe Ala Thr Glu Ala His 
145                 150                 155                 160


Lys Lys Leu Ser Glu Pro Leu Glu Val Ser Phe Met Asn Val Lys Leu 
                165                 170                 175


Leu Ile Gln Asp Leu Glu Asp Ile Glu Gln Arg Val Pro Val Met Asp 
            180                 185                 190


Ala Gln Tyr Lys Ile Ile Thr Lys Thr Ala His Leu Ile Thr Lys Glu 
        195                 200                 205


Ser Pro Gln Glu Glu Gly Lys Glu Met Phe Ala Thr Met Ser Lys Leu 
    210                 215                 220


Lys Glu Gln Leu Thr Lys Val Lys Glu Cys Tyr Ser Pro Leu Leu Tyr 
225                 230                 235                 240


Glu Ser Gln Gln Leu Leu Ile Pro Leu Glu Glu Leu Glu Lys Gln Met 
                245                 250                 255


Thr Ser Phe Tyr Asp Ser Leu Gly Lys Ile Asn Glu Ile Ile Thr Val 
            260                 265                 270


Leu Glu Arg Glu Ala Gln Ser Ser Ala Leu Phe Lys Gln Lys His Gln 
        275                 280                 285


Glu Leu Leu Ala Cys Gln Glu Asn Cys Lys Lys Thr Leu Thr Leu Ile 
    290                 295                 300


Glu Lys Gly Ser Gln Ser Val Gln Lys Phe Val Thr Leu Ser Asn Val 
305                 310                 315                 320


Leu Lys His Phe Asp Gln Thr Arg Leu Gln Arg Gln Ile Ala Asp Ile 
                325                 330                 335


His Val Ala Phe Gln Ser Met Val Lys Lys Thr Gly Asp Trp Lys Lys 
            340                 345                 350


His Val Glu Thr Asn Ser Arg Leu Met Lys Lys Phe Glu Glu Ser Arg 
        355                 360                 365


Ala Glu Leu Glu Lys Val Leu Arg Ile Ala Gln Glu Gly Leu Glu Glu 
    370                 375                 380


Lys Gly Asp Pro Glu Glu Leu Leu Arg Arg His Thr Glu Phe Phe Ser 
385                 390                 395                 400


Gln Leu Asp Gln Arg Val Leu Asn Ala Phe Leu Lys Ala Cys Asp Glu 
                405                 410                 415


Leu Thr Asp Ile Leu Pro Glu Gln Glu Gln Gln Gly Leu Gln Glu Ala 
            420                 425                 430


Val Arg Lys Leu His Lys Gln Trp Lys Val Ser Gln Asp Arg Thr Glu 
        435                 440                 445


Thr Pro Cys Ile Leu Asn Glu Gly Arg Ser Leu Ser Val Leu Arg Ser 
    450                 455                 460


Lys Cys Lys Arg Asn Leu Glu Ile Pro Gly Lys Ser Leu 
465                 470                 475


<210>  3434
<211>  702
<212>  DNA
<213>  Homo sapiens

<400>  3434
ggcaaataca cctcaataaa atattggaat gaaattgaaa aaatagacaa atgcagattg     60

aatttcttcc cacaaccaaa tgacgtgaat acaaagggga aaacaacagc aaaggcatac    120

agtgacaagg aggtggtctc atttccccag accttgagtc tgggctggca ttgagatcta    180

cattgatcaa taatatgaca gaagtgattt taagtgacat ctgaggctgg gccttaagag    240

gacttgagat tccactttgg ctatattgga attcaactct gctctgagac ctctacacaa    300

ggaaactggt ctaagatcct cgtgaataag aagtcacttg gaggatagat tctaaacctc    360

aagaataaga aataaaagta caaattggtg tgatgaaggt atattcctat ttttggggat    420

tgggaggctt tacttatttt taaaaactct attgaggtaa agagttaagc tgtaacatac    480

ttcattgatt tcctcaccct tttcggctct gttttactat atcccctaat ttgttggttg    540

tgctaatatt tgtagaaaga ggtcttgtat ttgctgcatc ataatgacat ttgtactttt    600

ttgactggtt taagtacaaa tgaatgaaat aaccattttt cctttagttg actttaccct    660

gatttcacct agtgtttcaa tgagtaaaaa tacagctaaa ag                       702


<210>  3435
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  3435

Gly Lys Tyr Thr Ser Ile Lys Tyr Trp Asn Glu Ile Glu Lys Ile Asp 
1               5                   10                  15


Lys Cys Arg Leu Asn Phe Phe Pro Gln Pro Asn Asp Val Asn Thr Lys 
            20                  25                  30


Gly Lys Thr Thr Ala Lys Ala Tyr Ser Asp Lys Glu Val Val Ser Phe 
        35                  40                  45


Pro Gln Thr Leu Ser Leu Gly Trp His 
    50                  55


<210>  3436
<211>  7708
<212>  DNA
<213>  Homo sapiens

<400>  3436
atgggtggag tctcgctttt tctttccagt gttggctgac ttacagctct tataaactag     60

tggcaatttc tgaacccagc cggctccatc tcagcttctg gtttctaagt ccatgtgcca    120

aaggctgcca ggaaggagac gccttcctga gtcctggatc tttcttcctt ctggaaatct    180

ttgactgtgg gtagttattt atttctgaat aagagcgtcc acgcatcatg gacctcgcgg    240

gactgctgaa gtctcagttc ctgtgccacc tggtcttctg ctacgtcttt attgcctcag    300

ggctaatcat caacaccatt cagctcttca ctctcctcct ctggcccatt aacaagcagc    360

tcttccggaa gatcaactgc agactgtcct attgcatctc aagccggctc caaggtcctg    420

gccaagaaag agctggccta tgtcccaatt atcggctgga tgtggtactt caccgagatg    480

gtcttctgtt cgcgcaagtg ggagcaggat cgcaagacgg ttgccaccag tttgcagcac    540

ctccgggact accccgagaa gtattttttc ctgattcact gtgagggcac acggttcacg    600

gagaagaagc atgagatcag catgcaggtg gcccgggcca aggggctgcc tcgcctcaag    660

catcacctgt tgccacgaac caagggcttc gccatcaccg tgaggagctt gagaaatgta    720

gtttcagctg tatatgactg tacactcaat ttcagaaata atgaaaatcc aacactgctg    780

ggagtcctaa acggaaagaa ataccatgca gatttgtatg ttaggaggat cccactggaa    840

gacatccctg aagacgatga cgagtgctcg gcctggctgc acaagctcta ccaggagaag    900

gatgcctttc aggaggagta ctacaggacg ggcaccttcc cagagacgcc catggtgccc    960

ccccggcggc cctggaccct cgtgaactgg ctgttttggg cctcgctggt gctctaccct   1020

ttcttccagt tcctggtcag catgatcagg agcgggtctt ccctgacgct ggccagcttc   1080

atcctcgtct tctttgtggc ctccgtggga gttcgatgga tgattggtgt gacggaaatt   1140

gacaagggct ctgcctacgg caactctgac agcaagcaga aactgaatga ctgactcagg   1200

gaggtgtcac catccgaagg gaaccttggg gaactggtgg cctctgcata tcctccttag   1260

tgggacacgg tgacaaaggc tgggtgagcc cctgctgggc acggcggaag tcacgacctc   1320

tccagccagg gagtctggtc tcaaggccgg atggggagga agatgttttg taatcttttt   1380

ttccccatgt gctttagtgg gctttggttt tctttttgtg cgagtgtgtg tgagaatggc   1440

tgtgtggtga gtgtgaactt tgttctgtga tcatagaaag ggtattttag gctgcagggg   1500

agggcagggc tggggaccga aggggacaag ttcccctttc atcctttggt gctgagtttt   1560

ctgtaaccct tggttgccag agataaagtg aaaagtgctt taggtgagat gactaaatta   1620

tgcctccaag aaaaaaaaat taaagtgctt ttctgggtca tctgtggtgt atgttgacat   1680

ggaccgctgc ccctccatcc tgcccttgcc cgtggctttg gtgtttcaga tcctactcac   1740

gggaggcagc tgccgcggag gtgtgggcag ctgagagggg tgggcaggcc agcacagctc   1800

ctggcaggag acacaggtcc aggagcccgt gagcatttgt gagagcagag atggcaagca   1860

cgtgcgtgga gaccaacgaa gcgtgtccct ggcacacagc aagggagagt ttcgctcggt   1920

ctctgcagtg cagtctcctg gcgtaagtct tgaagatgga cccaactccc tgaagaaatg   1980

gatcttgaaa ttgaacacaa acatcatgaa cgtacagcct gggcattctg cagtgatttg   2040

tgagatgagc ttgcatcgac tgttcctctc agcagtgaca gccaaagtca cccctgataa   2100

aatgcagttt cactttataa aatgcctcgc cccttcccag catgtagagc ttgtctgcag   2160

ccctaaagga gccaggtcct gctctgatga gggtcaaatc agagccgaca tcccatgtac   2220

aaaaaacccc caggcttctg ccttccttcc gggctcctgt ctgctcccat tttactccac   2280

ggaatagttc tgccctgtag catctccagc ggcctttgca gactgctgtc agccaacagg   2340

tgccaaaaat gcaaaagaag aagaaactaa aagcagtgct atttttgcag aacaaatgct   2400

agctattaaa tcatcttagg ccaagacacc aatggcactt ggaccgatag gtatttggag   2460

catgagttag gaaggatatg tctttctcca ggtgcgcagc tgaaagttgc tgagaaaagc   2520

tgcctgtgtt gctgtggtaa catgagaagg aatgaacagc tctatacaaa aactggccac   2580

acattataag gcctattcta tgcagttatg tttttggcta tttgctcatt tagtcattgt   2640

ttatcaacca aactaggtaa gccaaggagt tacaagacag ctctagagaa gctccctctg   2700

cttacaggac aataatgcat tgtttgtttg ttgatacaaa tgaattattt gaatccacag   2760

aagtgaaaaa gggaaaaaat cctggctgac ttgtgggaag agcgtactgc agagcctagg   2820

gcctgagtta actcgctggc ggccctgcag gcaggcttga tgggagcgcc cagcacatct   2880

gcccaccctg cacagggcat gaagcaccgt gtgcagagat ctgtgggcaa aagcccagga   2940

cgtgacctta ggcaagaggg gtccttggag aagtggaggt gtgcatggtg tgtagccttg   3000

cgtgtctgtg agcacgccct agtggacctg cgcctggatt atcgggccag tctctcggag   3060

gggtccgtga tgctgagtta cgccattcac ctgaactctg cagctcatcg gctgtaggat   3120

ttgggtgaga cacttttcct tgctgactca tttccccatc tgcaaaatgg gggtgacgat   3180

atctacctct tggggtgtgt caagggtaaa agagcacact ttaagaatcc taaagcacta   3240

agccaaggat gaaagactag aaagctgcct ctatgttgct actctcaaaa atgctcagaa   3300

attttcttgt cgtactaaaa atgtgttatt tttctcattt tcattcttcc attcaacaca   3360

gaagtaatct aagtaagttc taaaaacata gatccggggg cccacagaca ttcaattttc   3420

ttctgaattg gctctggtat cacacaacac acaagcaagc aaacagcctg cctgctaggg   3480

ccttgggttc caggctggag gaatgcaggc agaaatctct taggaaataa ctaagtgagc   3540

gccaagtttt gaattgcctt agagccgaaa gagaatgtgg cgtgctgggg agagatctgg   3600

acctctttct catcagtcat ttgacctgtc cacgaagaac aattttgtta tgcagcctgg   3660

gaacctggtt tccttacacc ctgcgccctt aatgacacag acaaccacgg gtactcctgg   3720

acggaagctc atcacgcctc ctcaaatacc ttcacccatg ttcaggtcac acggaggtca   3780

ccatctcctc agcacacaac aactgctttg gttcccaggg ttattttttc tacgagttga   3840

aaacccacgg agcctaagcc atctttttgt cccctaagga gagccccata gactaagagc   3900

tacacttcct gtctgtcttt cccacctttc catctcattc tagcttaaag cttatcacgc   3960

tactgagagc ctgttctgta gttcaaggtg gcagagaaaa atacgaacct tgagtgaaat   4020

ctggagagca gtgcagggtc atccccagac gtgacgggcc atatcctagg cgactcctgc   4080

agcttataga agcagggaat ttaatggact tcttccagga aagccagccc acggggactc   4140

ttaaaaagac accaaccatt tggaagatgc agcttgaggt ctgggggact ggactgattc   4200

tgccaccata tagtgaacac gattaatcgg gaggaagaag taaggcactc tgtgagttag   4260

tctaccaccc tattgacttt gacagagaga aaaccaactt ttttcatatg atcacacagt   4320

agtactggaa tatctcgact gcaatatcct ctaaacaaat gcatgcaaag ctttgtaaaa   4380

gcagctgatg attaaaaaaa ttttaaaaca ttagggtttt tctaatatat ccatatgtgg   4440

gacagtgatt taaatgtcat taattgtcca gccacaactt gtaacagtga tgtgaaagac   4500

acaaaaaagg ccccactgga gtggaggagt ggtctggctg gtccccaagc aaaacagaat   4560

gggcttcgca taggctttag aacttattca taaatattga ccaaagtgtg aagcaaggta   4620

tccagtgaag attctctagg gtctctactt ctgctcaaga gatttaatcc agctttctct   4680

aaagcagtgg tccagacttg ccacatacta ggttaaagat aaagtgagaa aaacaaatac   4740

tttggtttgc acgtctcttg aggggcccta ggctgtatgg aggaatattt agaggaatat   4800

ttgtgagctg ccatttgtgt ttaaaagaac atgaaagcaa gacgggccct aacccgcctg   4860

tgtctgtagc tgaccaggag gccactgctt ccttccccca gagcttctag gagagccccc   4920

caaaatgcaa ctctccaagg tcctgtggag tagtcccctc ataatgcctc caccacacct   4980

gtgtctcacg atgccttaac tgacgtagct cctaagtgat gttcacagag aaggaaatac   5040

ttaggcaagc ccatgtgtaa catgctcaca gatgtgctgg ctttgccaat gctttcggac   5100

tccaccatgc tttctgattc ttctggtcct agtcacgcct tggcacgggg cagaagcggc   5160

cgagctatgc tgacaggtgc tgctgagagc caacagccat tcagccgaga aggcgtttct   5220

aggtgagggc atgagagctg gcattccagg ctgctgagtg cggcatctgc aggtgcacca   5280

cattgctcca cggtgtgttc agaagagacc agcatcttga atctcaggct ctgggctcat   5340

tctttgcctc tgccaaggga ccattcaggg gcttcaagcc agctgctgaa aatccccctt   5400

ttctggattt ttccccatct atataaggat atggtggctg tgtggacaag aaattggttt   5460

catctcagaa gggtgcttcc ctacaaagat cttcagaaat ttaattgaaa acaatttttt   5520

gaactttttt tgtttggcca ggatgaatga agctgaagtc acatcctgaa tgtgcatgcc   5580

agacaaaggg taagcaagca gtctttacaa atgccaatcc ctctgcactc caaaaccgga   5640

gcccgtaatg aaggcccagg ttccagtcat cacaggatcc cccaagccag cacagtgcct   5700

gatgcctccc taggcattag cacatcccag cactctaatt cacatcctca gcatccctgc   5760

ctcctgcatc cagggcttag gttgagtgtt tccagagtgt caagtacatt taaacacaaa   5820

ccaaatactc cagggttttg acctgtcaca atggcttttg aaaacaacag acgtacaatt   5880

tgagagaagg actcgatgga cttcttaggc tgaggactaa ggacatgttg ctgttcctct   5940

tggtccagga cattcaatac cattcacagc attcatcacc aactgacata gtatcgatca   6000

cgacattcaa ctgtttgaaa ttactgctat tttggtcaaa aactaagaaa tcagaaattg   6060

cacctacata gtgtgtctcc tcattggagt cccatctctc tgagcacagg gatgggctcc   6120

tgagctcaca gccctgccct gcccccccag cagggcctca ccctcatggc cctcagtgaa   6180

tagtgactac atgaaggggg cacttactag aggcctgagt aatggaattt caattagctt   6240

ctgcttccct tttctaaaaa agaaccacct ttcttaagaa taattaggcc aaaataaact   6300

tgagtaattt gtacagtcaa tattttgaag tttcggagtt accagtgaaa tagcaaagct   6360

gttctccagg aaaggacatc caggttccca cccaggcctt ccttcctcag ctcctgcagc   6420

ctcatcctag tttaatatga aggttgtgaa tgggttaaaa agcagttctt aagcacctac   6480

ttagatcttt tcagtatctg gaaatagcac ccagggctgt gttagtaaag cttttcactg   6540

ggtaagagtc atacaatttt tacatttaat ttgttttttt aaaacaaggc agtcttgttt   6600

tacatattgg aatgactaga tattttttga catttctggc acctctggtt ctgctgaatt   6660

ttaagggagg tgagtggtat gtacacaaag ttaagattgc tgcataataa ttcctttgca   6720

tttccaaaat aaattacaca aatgtcactt ttccttttct attccatagt actagtttta   6780

gccagatctt tgccaaacat tctaggacat tcagaaaagt catccatgga attttggaat   6840

gccattctct ctgtatcttt gcagatcatg aggaaggaaa gttgatgaac tagtacggga   6900

tggctcagac ttgtaaagtg tctaagtcac aacgctgcag agccagcttc cgggtagcaa   6960

tggcatggcc tcagctgtgc caaggctaca actggagctt ccttactcgc atctgaggca   7020

aacacagcaa ggctggccca ggccgcccac agtcaacaga tgttcacggg agatggatca   7080

gcccctcttt tgcttgttct atcaaggaaa gagatctaac catgggcaag ggtggaacac   7140

acccggttca ggtcagggaa tgagttgctc taagtgaaca gtgaattctt acttctcagc   7200

ctgtatcaat tgtacccagg gttcatgatt actgtgaccc actaagggat gatctttgag   7260

gaaacagacc tggagggagg taatttaagg agggaaagcg agtgggtttt acagactgct   7320

ttgtggcgac attcaggaac agaccattca atggatgact tttcagtaca taaaagcaag   7380

cagtaatggc caggagagag caaagatgcc ctaagaatga catcagactg accaaatgtg   7440

ccttttcaaa taagttatga gaacgaatga attggaatta gagcaaggta ttggacagaa   7500

ccatgctagt ctttgagaga acgtgtggat tgggtggatg tttggaccga atgaatggta   7560

actttttaat gtgaaacaga gaactgatat atgggctgtc atgtcaccct agggtactgt   7620

cgctctgtca tgtgtagcaa tctttccaaa tttttgttgg tgggctgaac aaagataaaa   7680

ctaataaagt atgtgtggat accactag                                      7708


<210>  3437
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  3437

Met Trp Tyr Phe Thr Glu Met Val Phe Cys Ser Arg Lys Trp Glu Gln 
1               5                   10                  15


Asp Arg Lys Thr Val Ala Thr Ser Leu Gln His Leu Arg Asp Tyr Pro 
            20                  25                  30


Glu Lys Tyr Phe Phe Leu Ile His Cys Glu Gly Thr Arg Phe Thr Glu 
        35                  40                  45


Lys Lys His Glu Ile Ser Met Gln Val Ala Arg Ala Lys Gly Leu Pro 
    50                  55                  60


Arg Leu Lys His His Leu Leu Pro Arg Thr Lys Gly Phe Ala Ile Thr 
65                  70                  75                  80


Val Arg Ser Leu Arg Asn Val Val Ser Ala Val Tyr Asp Cys Thr Leu 
                85                  90                  95


Asn Phe Arg Asn Asn Glu Asn Pro Thr Leu Leu Gly Val Leu Asn Gly 
            100                 105                 110


Lys Lys Tyr His Ala Asp Leu Tyr Val Arg Arg Ile Pro Leu Glu Asp 
        115                 120                 125


Ile Pro Glu Asp Asp Asp Glu Cys Ser Ala Trp Leu His Lys Leu Tyr 
    130                 135                 140


Gln Glu Lys Asp Ala Phe Gln Glu Glu Tyr Tyr Arg Thr Gly Thr Phe 
145                 150                 155                 160


Pro Glu Thr Pro Met Val Pro Pro Arg Arg Pro Trp Thr Leu Val Asn 
                165                 170                 175


Trp Leu Phe Trp Ala Ser Leu Val Leu Tyr Pro Phe Phe Gln Phe Leu 
            180                 185                 190


Val Ser Met Ile Arg Ser Gly Ser Ser Leu Thr Leu Ala Ser Phe Ile 
        195                 200                 205


Leu Val Phe Phe Val Ala Ser Val Gly Val Arg Trp Met Ile Gly Val 
    210                 215                 220


Thr Glu Ile Asp Lys Gly Ser Ala Tyr Gly Asn Ser Asp Ser Lys Gln 
225                 230                 235                 240


Lys Leu Asn Asp 



<210>  3438
<211>  8015
<212>  DNA
<213>  Homo sapiens

<400>  3438
atgggtggag tctcgctttt tctttccagt gttggctgac ttacagctct tataaactag     60

tggcaatttc tgaacccagc cggctccatc tcagcttctg gtttctaagt ccatgtgcca    120

aaggctgcca ggaaggagac gccttcctga gtcctggatc tttcttcctt ctggaaatct    180

ttgactgtgg gtagttattt atttctgaat aagagcgtcc acgcatcatg gacctcgcgg    240

gactgctgaa gtctcagttc ctgtgccacc tggtcttctg ctacgtcttt attgcctcag    300

ggctaatcat caacaccatt cagctcttca ctctcctcct ctggcccatt aacaagcagc    360

tcttccggaa gatcaactgc agactgtcct attgcatctc aagccagctg gtgatgctgc    420

tggagtggtg gtcgggcacg gaatgcacca tcttcacgga cccgcgcgcc tacctcaagt    480

atgggaagga aaatgccatc gtggttctca accacaagtt tgaaattgac tttctgtgtg    540

gctggagcct gtccgaacgc tttgggctgt tagggtttga cctcttgcac gtagcttgca    600

tgcctttgga actgggtctc ttcagttgac ttttgtcgtc ttcaacacac tgcagcgtgt    660

agcggttgag cctgtgtcac atagctgaat cagagtcatc tgcggtactc agggctccaa    720

ggtcctggcc aagaaagagc tggcctatgt cccaattatc ggctggatgt ggtacttcac    780

cgagatggtc ttctgttcgc gcaagtggga gcaggatcgc aagacggttg ccaccagttt    840

gcagcacctc cgggactacc ccgagaagta ttttttcctg attcactgtg agggcacacg    900

gttcacggag aagaagcatg agatcagcat gcaggtggcc cgggccaagg ggctgcctcg    960

cctcaagcat cacctgttgc cacgaaccaa gggcttcgcc atcaccgtga ggagcttgag   1020

aaatgtagtt tcagctgtat atgactgtac actcaatttc agaaataatg aaaatccaac   1080

actgctggga gtcctaaacg gaaagaaata ccatgcagat ttgtatgtta ggaggatccc   1140

actggaagac atccctgaag acgatgacga gtgctcggcc tggctgcaca agctctacca   1200

ggagaaggat gcctttcagg aggagtacta caggacgggc accttcccag agacgcccat   1260

ggtgcccccc cggcggccct ggaccctcgt gaactggctg ttttgggcct cgctggtgct   1320

ctaccctttc ttccagttcc tggtcagcat gatcaggagc gggtcttccc tgacgctggc   1380

cagcttcatc ctcgtcttct ttgtggcctc cgtgggagtt cgatggatga ttggtgtgac   1440

ggaaattgac aagggctctg cctacggcaa ctctgacagc aagcagaaac tgaatgactg   1500

actcagggag gtgtcaccat ccgaagggaa ccttggggaa ctggtggcct ctgcatatcc   1560

tccttagtgg gacacggtga caaaggctgg gtgagcccct gctgggcacg gcggaagtca   1620

cgacctctcc agccagggag tctggtctca aggccggatg gggaggaaga tgttttgtaa   1680

tctttttttc cccatgtgct ttagtgggct ttggttttct ttttgtgcga gtgtgtgtga   1740

gaatggctgt gtggtgagtg tgaactttgt tctgtgatca tagaaagggt attttaggct   1800

gcaggggagg gcagggctgg ggaccgaagg ggacaagttc ccctttcatc ctttggtgct   1860

gagttttctg taacccttgg ttgccagaga taaagtgaaa agtgctttag gtgagatgac   1920

taaattatgc ctccaagaaa aaaaaattaa agtgcttttc tgggtcatct gtggtgtatg   1980

ttgacatgga ccgctgcccc tccatcctgc ccttgcccgt ggctttggtg tttcagatcc   2040

tactcacggg aggcagctgc cgcggaggtg tgggcagctg agaggggtgg gcaggccagc   2100

acagctcctg gcaggagaca caggtccagg agcccgtgag catttgtgag agcagagatg   2160

gcaagcacgt gcgtggagac caacgaagcg tgtccctggc acacagcaag ggagagtttc   2220

gctcggtctc tgcagtgcag tctcctggcg taagtcttga agatggaccc aactccctga   2280

agaaatggat cttgaaattg aacacaaaca tcatgaacgt acagcctggg cattctgcag   2340

tgatttgtga gatgagcttg catcgactgt tcctctcagc agtgacagcc aaagtcaccc   2400

ctgataaaat gcagtttcac tttataaaat gcctcgcccc ttcccagcat gtagagcttg   2460

tctgcagccc taaaggagcc aggtcctgct ctgatgaggg tcaaatcaga gccgacatcc   2520

catgtacaaa aaacccccag gcttctgcct tccttccggg ctcctgtctg ctcccatttt   2580

actccacgga atagttctgc cctgtagcat ctccagcggc ctttgcagac tgctgtcagc   2640

caacaggtgc caaaaatgca aaagaagaag aaactaaaag cagtgctatt tttgcagaac   2700

aaatgctagc tattaaatca tcttaggcca agacaccaat ggcacttgga ccgataggta   2760

tttggagcat gagttaggaa ggatatgtct ttctccaggt gcgcagctga aagttgctga   2820

gaaaagctgc ctgtgttgct gtggtaacat gagaaggaat gaacagctct atacaaaaac   2880

tggccacaca ttataaggcc tattctatgc agttatgttt ttggctattt gctcatttag   2940

tcattgttta tcaaccaaac taggtaagcc aaggagttac aagacagctc tagagaagct   3000

ccctctgctt acaggacaat aatgcattgt ttgtttgttg atacaaatga attatttgaa   3060

tccacagaag tgaaaaaggg aaaaaatcct ggctgacttg tgggaagagc gtactgcaga   3120

gcctagggcc tgagttaact cgctggcggc cctgcaggca ggcttgatgg gagcgcccag   3180

cacatctgcc caccctgcac agggcatgaa gcaccgtgtg cagagatctg tgggcaaaag   3240

cccaggacgt gaccttaggc aagaggggtc cttggagaag tggaggtgtg catggtgtgt   3300

agccttgcgt gtctgtgagc acgccctagt ggacctgcgc ctggattatc gggccagtct   3360

ctcggagggg tccgtgatgc tgagttacgc cattcacctg aactctgcag ctcatcggct   3420

gtaggatttg ggtgagacac ttttccttgc tgactcattt ccccatctgc aaaatggggg   3480

tgacgatatc tacctcttgg ggtgtgtcaa gggtaaaaga gcacacttta agaatcctaa   3540

agcactaagc caaggatgaa agactagaaa gctgcctcta tgttgctact ctcaaaaatg   3600

ctcagaaatt ttcttgtcgt actaaaaatg tgttattttt ctcattttca ttcttccatt   3660

caacacagaa gtaatctaag taagttctaa aaacatagat ccgggggccc acagacattc   3720

aattttcttc tgaattggct ctggtatcac acaacacaca agcaagcaaa cagcctgcct   3780

gctagggcct tgggttccag gctggaggaa tgcaggcaga aatctcttag gaaataacta   3840

agtgagcgcc aagttttgaa ttgccttaga gccgaaagag aatgtggcgt gctggggaga   3900

gatctggacc tctttctcat cagtcatttg acctgtccac gaagaacaat tttgttatgc   3960

agcctgggaa cctggtttcc ttacaccctg cgcccttaat gacacagaca accacgggta   4020

ctcctggacg gaagctcatc acgcctcctc aaataccttc acccatgttc aggtcacacg   4080

gaggtcacca tctcctcagc acacaacaac tgctttggtt cccagggtta ttttttctac   4140

gagttgaaaa cccacggagc ctaagccatc tttttgtccc ctaaggagag ccccatagac   4200

taagagctac acttcctgtc tgtctttccc acctttccat ctcattctag cttaaagctt   4260

atcacgctac tgagagcctg ttctgtagtt caaggtggca gagaaaaata cgaaccttga   4320

gtgaaatctg gagagcagtg cagggtcatc cccagacgtg acgggccata tcctaggcga   4380

ctcctgcagc ttatagaagc agggaattta atggacttct tccaggaaag ccagcccacg   4440

gggactctta aaaagacacc aaccatttgg aagatgcagc ttgaggtctg ggggactgga   4500

ctgattctgc caccatatag tgaacacgat taatcgggag gaagaagtaa ggcactctgt   4560

gagttagtct accaccctat tgactttgac agagagaaaa ccaacttttt tcatatgatc   4620

acacagtagt actggaatat ctcgactgca atatcctcta aacaaatgca tgcaaagctt   4680

tgtaaaagca gctgatgatt aaaaaaattt taaaacatta gggtttttct aatatatcca   4740

tatgtgggac agtgatttaa atgtcattaa ttgtccagcc acaacttgta acagtgatgt   4800

gaaagacaca aaaaaggccc cactggagtg gaggagtggt ctggctggtc cccaagcaaa   4860

acagaatggg cttcgcatag gctttagaac ttattcataa atattgacca aagtgtgaag   4920

caaggtatcc agtgaagatt ctctagggtc tctacttctg ctcaagagat ttaatccagc   4980

tttctctaaa gcagtggtcc agacttgcca catactaggt taaagataaa gtgagaaaaa   5040

caaatacttt ggtttgcacg tctcttgagg ggccctaggc tgtatggagg aatatttaga   5100

ggaatatttg tgagctgcca tttgtgttta aaagaacatg aaagcaagac gggccctaac   5160

ccgcctgtgt ctgtagctga ccaggaggcc actgcttcct tcccccagag cttctaggag   5220

agccccccaa aatgcaactc tccaaggtcc tgtggagtag tcccctcata atgcctccac   5280

cacacctgtg tctcacgatg ccttaactga cgtagctcct aagtgatgtt cacagagaag   5340

gaaatactta ggcaagccca tgtgtaacat gctcacagat gtgctggctt tgccaatgct   5400

ttcggactcc accatgcttt ctgattcttc tggtcctagt cacgccttgg cacggggcag   5460

aagcggccga gctatgctga caggtgctgc tgagagccaa cagccattca gccgagaagg   5520

cgtttctagg tgagggcatg agagctggca ttccaggctg ctgagtgcgg catctgcagg   5580

tgcaccacat tgctccacgg tgtgttcaga agagaccagc atcttgaatc tcaggctctg   5640

ggctcattct ttgcctctgc caagggacca ttcaggggct tcaagccagc tgctgaaaat   5700

cccccttttc tggatttttc cccatctata taaggatatg gtggctgtgt ggacaagaaa   5760

ttggtttcat ctcagaaggg tgcttcccta caaagatctt cagaaattta attgaaaaca   5820

attttttgaa ctttttttgt ttggccagga tgaatgaagc tgaagtcaca tcctgaatgt   5880

gcatgccaga caaagggtaa gcaagcagtc tttacaaatg ccaatccctc tgcactccaa   5940

aaccggagcc cgtaatgaag gcccaggttc cagtcatcac aggatccccc aagccagcac   6000

agtgcctgat gcctccctag gcattagcac atcccagcac tctaattcac atcctcagca   6060

tccctgcctc ctgcatccag ggcttaggtt gagtgtttcc agagtgtcaa gtacatttaa   6120

acacaaacca aatactccag ggttttgacc tgtcacaatg gcttttgaaa acaacagacg   6180

tacaatttga gagaaggact cgatggactt cttaggctga ggactaagga catgttgctg   6240

ttcctcttgg tccaggacat tcaataccat tcacagcatt catcaccaac tgacatagta   6300

tcgatcacga cattcaactg tttgaaatta ctgctatttt ggtcaaaaac taagaaatca   6360

gaaattgcac ctacatagtg tgtctcctca ttggagtccc atctctctga gcacagggat   6420

gggctcctga gctcacagcc ctgccctgcc cccccagcag ggcctcaccc tcatggccct   6480

cagtgaatag tgactacatg aagggggcac ttactagagg cctgagtaat ggaatttcaa   6540

ttagcttctg cttccctttt ctaaaaaaga accacctttc ttaagaataa ttaggccaaa   6600

ataaacttga gtaatttgta cagtcaatat tttgaagttt cggagttacc agtgaaatag   6660

caaagctgtt ctccaggaaa ggacatccag gttcccaccc aggccttcct tcctcagctc   6720

ctgcagcctc atcctagttt aatatgaagg ttgtgaatgg gttaaaaagc agttcttaag   6780

cacctactta gatcttttca gtatctggaa atagcaccca gggctgtgtt agtaaagctt   6840

ttcactgggt aagagtcata caatttttac atttaatttg tttttttaaa acaaggcagt   6900

cttgttttac atattggaat gactagatat tttttgacat ttctggcacc tctggttctg   6960

ctgaatttta agggaggtga gtggtatgta cacaaagtta agattgctgc ataataattc   7020

ctttgcattt ccaaaataaa ttacacaaat gtcacttttc cttttctatt ccatagtact   7080

agttttagcc agatctttgc caaacattct aggacattca gaaaagtcat ccatggaatt   7140

ttggaatgcc attctctctg tatctttgca gatcatgagg aaggaaagtt gatgaactag   7200

tacgggatgg ctcagacttg taaagtgtct aagtcacaac gctgcagagc cagcttccgg   7260

gtagcaatgg catggcctca gctgtgccaa ggctacaact ggagcttcct tactcgcatc   7320

tgaggcaaac acagcaaggc tggcccaggc cgcccacagt caacagatgt tcacgggaga   7380

tggatcagcc cctcttttgc ttgttctatc aaggaaagag atctaaccat gggcaagggt   7440

ggaacacacc cggttcaggt cagggaatga gttgctctaa gtgaacagtg aattcttact   7500

tctcagcctg tatcaattgt acccagggtt catgattact gtgacccact aagggatgat   7560

ctttgaggaa acagacctgg agggaggtaa tttaaggagg gaaagcgagt gggttttaca   7620

gactgctttg tggcgacatt caggaacaga ccattcaatg gatgactttt cagtacataa   7680

aagcaagcag taatggccag gagagagcaa agatgcccta agaatgacat cagactgacc   7740

aaatgtgcct tttcaaataa gttatgagaa cgaatgaatt ggaattagag caaggtattg   7800

gacagaacca tgctagtctt tgagagaacg tgtggattgg gtggatgttt ggaccgaatg   7860

aatggtaact ttttaatgtg aaacagagaa ctgatatatg ggctgtcatg tcaccctagg   7920

gtactgtcgc tctgtcatgt gtagcaatct ttccaaattt ttgttggtgg gctgaacaaa   7980

gataaaacta ataaagtatg tgtggatacc actag                              8015


<210>  3439
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  3439

Met Trp Tyr Phe Thr Glu Met Val Phe Cys Ser Arg Lys Trp Glu Gln 
1               5                   10                  15


Asp Arg Lys Thr Val Ala Thr Ser Leu Gln His Leu Arg Asp Tyr Pro 
            20                  25                  30


Glu Lys Tyr Phe Phe Leu Ile His Cys Glu Gly Thr Arg Phe Thr Glu 
        35                  40                  45


Lys Lys His Glu Ile Ser Met Gln Val Ala Arg Ala Lys Gly Leu Pro 
    50                  55                  60


Arg Leu Lys His His Leu Leu Pro Arg Thr Lys Gly Phe Ala Ile Thr 
65                  70                  75                  80


Val Arg Ser Leu Arg Asn Val Val Ser Ala Val Tyr Asp Cys Thr Leu 
                85                  90                  95


Asn Phe Arg Asn Asn Glu Asn Pro Thr Leu Leu Gly Val Leu Asn Gly 
            100                 105                 110


Lys Lys Tyr His Ala Asp Leu Tyr Val Arg Arg Ile Pro Leu Glu Asp 
        115                 120                 125


Ile Pro Glu Asp Asp Asp Glu Cys Ser Ala Trp Leu His Lys Leu Tyr 
    130                 135                 140


Gln Glu Lys Asp Ala Phe Gln Glu Glu Tyr Tyr Arg Thr Gly Thr Phe 
145                 150                 155                 160


Pro Glu Thr Pro Met Val Pro Pro Arg Arg Pro Trp Thr Leu Val Asn 
                165                 170                 175


Trp Leu Phe Trp Ala Ser Leu Val Leu Tyr Pro Phe Phe Gln Phe Leu 
            180                 185                 190


Val Ser Met Ile Arg Ser Gly Ser Ser Leu Thr Leu Ala Ser Phe Ile 
        195                 200                 205


Leu Val Phe Phe Val Ala Ser Val Gly Val Arg Trp Met Ile Gly Val 
    210                 215                 220


Thr Glu Ile Asp Lys Gly Ser Ala Tyr Gly Asn Ser Asp Ser Lys Gln 
225                 230                 235                 240


Lys Leu Asn Asp 



<210>  3440
<211>  7887
<212>  DNA
<213>  Homo sapiens

<400>  3440
gtccacccca tgggtggagt ctcgcttttt ctttccagtg ttggctgact tacagctctt     60

ataaactagt ggcaatttct gaacccagcc ggctccatct cagcttctgg tttctaagtc    120

catgtgccaa aggctgccag gaaggagacg ccttcctgag tcctggatct ttcttccttc    180

tggaaatctt tgactgtggg tagttattta tttctgaata agagcgtcca cgcatcatgg    240

acctcgcggg actgctgaag tctcagttcc tgtgccacct ggtcttctgc tacgtcttta    300

ttgcctcagg gctaatcatc aacaccattc agctcttcac tctcctcctc tggcccatta    360

acaagcagct cttccggaag atcaactgca gactgtccta ttgcatctca agccagctgg    420

tgatgctgct ggagtggtgg tcgggcacgg aatgcaccat cttcacggac ccgcgcgcct    480

acctcaagta tgggaaggaa aatgccatcg tggttctcaa ccacaagttt gaaattgact    540

ttctgtgtgg ctggagcctg tccgaacgct ttgggctgtt agggggctcc aaggtcctgg    600

ccaagaaaga gctggcctat gtcccaatta tcggctggat gtggtacttc accgagatgg    660

tcttctgttc gcgcaagtgg gagcaggatc gcaagacggt tgccaccagt ttgcagcacc    720

tccgggacta ccccgagaag tattttttcc tgattcactg tgagggcaca cggttcacgg    780

agaagaagca tgagatcagc atgcaggtgg cccgggccaa ggggctgcct cgcctcaagc    840

atcacctgtt gccacgaacc aagggcttcg ccatcaccgt gaggagcttg agaaatgtag    900

tttcagctgt atatgactgt acactcaatt tcagaaataa tgaaaatcca acactgctgg    960

gagtcctaaa cggaaagaaa taccatgcag atttgtatgt taggaggatc ccactggaag   1020

acatccctga agacgatgac gagtgctcgg cctggctgca caagctctac caggagaagg   1080

atgcctttca ggaggagtac tacaggacgg gcaccttccc agagacgccc atggtgcccc   1140

cccggcggcc ctggaccctc gtgaactggc tgttttgggc ctcgctggtg ctctaccctt   1200

tcttccagtt cctggtcagc atgatcagga gcgggtcttc cctgacgctg gccagcttca   1260

tcctcgtctt ctttgtggcc tccgtgggag ttcgatggat gattggtgtg acggaaattg   1320

acaagggctc tgcctacggc aactctgaca gcaagcagaa actgaatgac tgactcaggg   1380

aggtgtcacc atccgaaggg aaccttgggg aactggtggc ctctgcatat cctccttagt   1440

gggacacggt gacaaaggct gggtgagccc ctgctgggca cggcggaagt cacgacctct   1500

ccagccaggg agtctggtct caaggccgga tggggaggaa gatgttttgt aatctttttt   1560

tccccatgtg ctttagtggg ctttggtttt ctttttgtgc gagtgtgtgt gagaatggct   1620

gtgtggtgag tgtgaacttt gttctgtgat catagaaagg gtattttagg ctgcagggga   1680

gggcagggct ggggaccgaa ggggacaagt tcccctttca tcctttggtg ctgagttttc   1740

tgtaaccctt ggttgccaga gataaagtga aaagtgcttt aggtgagatg actaaattat   1800

gcctccaaga aaaaaaaatt aaagtgcttt tctgggtcat ctgtggtgta tgttgacatg   1860

gaccgctgcc cctccatcct gcccttgccc gtggctttgg tgtttcagat cctactcacg   1920

ggaggcagct gccgcggagg tgtgggcagc tgagaggggt gggcaggcca gcacagctcc   1980

tggcaggaga cacaggtcca ggagcccgtg agcatttgtg agagcagaga tggcaagcac   2040

gtgcgtggag accaacgaag cgtgtccctg gcacacagca agggagagtt tcgctcggtc   2100

tctgcagtgc agtctcctgg cgtaagtctt gaagatggac ccaactccct gaagaaatgg   2160

atcttgaaat tgaacacaaa catcatgaac gtacagcctg ggcattctgc agtgatttgt   2220

gagatgagct tgcatcgact gttcctctca gcagtgacag ccaaagtcac ccctgataaa   2280

atgcagtttc actttataaa atgcctcgcc ccttcccagc atgtagagct tgtctgcagc   2340

cctaaaggag ccaggtcctg ctctgatgag ggtcaaatca gagccgacat cccatgtaca   2400

aaaaaccccc aggcttctgc cttccttccg ggctcctgtc tgctcccatt ttactccacg   2460

gaatagttct gccctgtagc atctccagcg gcctttgcag actgctgtca gccaacaggt   2520

gccaaaaatg caaaagaaga agaaactaaa agcagtgcta tttttgcaga acaaatgcta   2580

gctattaaat catcttaggc caagacacca atggcacttg gaccgatagg tatttggagc   2640

atgagttagg aaggatatgt ctttctccag gtgcgcagct gaaagttgct gagaaaagct   2700

gcctgtgttg ctgtggtaac atgagaagga atgaacagct ctatacaaaa actggccaca   2760

cattataagg cctattctat gcagttatgt ttttggctat ttgctcattt agtcattgtt   2820

tatcaaccaa actaggtaag ccaaggagtt acaagacagc tctagagaag ctccctctgc   2880

ttacaggaca ataatgcatt gtttgtttgt tgatacaaat gaattatttg aatccacaga   2940

agtgaaaaag ggaaaaaatc ctggctgact tgtgggaaga gcgtactgca gagcctaggg   3000

cctgagttaa ctcgctggcg gccctgcagg caggcttgat gggagcgccc agcacatctg   3060

cccaccctgc acagggcatg aagcaccgtg tgcagagatc tgtgggcaaa agcccaggac   3120

gtgaccttag gcaagagggg tccttggaga agtggaggtg tgcatggtgt gtagccttgc   3180

gtgtctgtga gcacgcccta gtggacctgc gcctggatta tcgggccagt ctctcggagg   3240

ggtccgtgat gctgagttac gccattcacc tgaactctgc agctcatcgg ctgtaggatt   3300

tgggtgagac acttttcctt gctgactcat ttccccatct gcaaaatggg ggtgacgata   3360

tctacctctt ggggtgtgtc aagggtaaaa gagcacactt taagaatcct aaagcactaa   3420

gccaaggatg aaagactaga aagctgcctc tatgttgcta ctctcaaaaa tgctcagaaa   3480

ttttcttgtc gtactaaaaa tgtgttattt ttctcatttt cattcttcca ttcaacacag   3540

aagtaatcta agtaagttct aaaaacatag atccgggggc ccacagacat tcaattttct   3600

tctgaattgg ctctggtatc acacaacaca caagcaagca aacagcctgc ctgctagggc   3660

cttgggttcc aggctggagg aatgcaggca gaaatctctt aggaaataac taagtgagcg   3720

ccaagttttg aattgcctta gagccgaaag agaatgtggc gtgctgggga gagatctgga   3780

cctctttctc atcagtcatt tgacctgtcc acgaagaaca attttgttat gcagcctggg   3840

aacctggttt ccttacaccc tgcgccctta atgacacaga caaccacggg tactcctgga   3900

cggaagctca tcacgcctcc tcaaatacct tcacccatgt tcaggtcaca cggaggtcac   3960

catctcctca gcacacaaca actgctttgg ttcccagggt tattttttct acgagttgaa   4020

aacccacgga gcctaagcca tctttttgtc ccctaaggag agccccatag actaagagct   4080

acacttcctg tctgtctttc ccacctttcc atctcattct agcttaaagc ttatcacgct   4140

actgagagcc tgttctgtag ttcaaggtgg cagagaaaaa tacgaacctt gagtgaaatc   4200

tggagagcag tgcagggtca tccccagacg tgacgggcca tatcctaggc gactcctgca   4260

gcttatagaa gcagggaatt taatggactt cttccaggaa agccagccca cggggactct   4320

taaaaagaca ccaaccattt ggaagatgca gcttgaggtc tgggggactg gactgattct   4380

gccaccatat agtgaacacg attaatcggg aggaagaagt aaggcactct gtgagttagt   4440

ctaccaccct attgactttg acagagagaa aaccaacttt tttcatatga tcacacagta   4500

gtactggaat atctcgactg caatatcctc taaacaaatg catgcaaagc tttgtaaaag   4560

cagctgatga ttaaaaaaat tttaaaacat tagggttttt ctaatatatc catatgtggg   4620

acagtgattt aaatgtcatt aattgtccag ccacaacttg taacagtgat gtgaaagaca   4680

caaaaaaggc cccactggag tggaggagtg gtctggctgg tccccaagca aaacagaatg   4740

ggcttcgcat aggctttaga acttattcat aaatattgac caaagtgtga agcaaggtat   4800

ccagtgaaga ttctctaggg tctctacttc tgctcaagag atttaatcca gctttctcta   4860

aagcagtggt ccagacttgc cacatactag gttaaagata aagtgagaaa aacaaatact   4920

ttggtttgca cgtctcttga ggggccctag gctgtatgga ggaatattta gaggaatatt   4980

tgtgagctgc catttgtgtt taaaagaaca tgaaagcaag acgggcccta acccgcctgt   5040

gtctgtagct gaccaggagg ccactgcttc cttcccccag agcttctagg agagcccccc   5100

aaaatgcaac tctccaaggt cctgtggagt agtcccctca taatgcctcc accacacctg   5160

tgtctcacga tgccttaact gacgtagctc ctaagtgatg ttcacagaga aggaaatact   5220

taggcaagcc catgtgtaac atgctcacag atgtgctggc tttgccaatg ctttcggact   5280

ccaccatgct ttctgattct tctggtccta gtcacgcctt ggcacggggc agaagcggcc   5340

gagctatgct gacaggtgct gctgagagcc aacagccatt cagccgagaa ggcgtttcta   5400

ggtgagggca tgagagctgg cattccaggc tgctgagtgc ggcatctgca ggtgcaccac   5460

attgctccac ggtgtgttca gaagagacca gcatcttgaa tctcaggctc tgggctcatt   5520

ctttgcctct gccaagggac cattcagggg cttcaagcca gctgctgaaa atcccccttt   5580

tctggatttt tccccatcta tataaggata tggtggctgt gtggacaaga aattggtttc   5640

atctcagaag ggtgcttccc tacaaagatc ttcagaaatt taattgaaaa caattttttg   5700

aacttttttt gtttggccag gatgaatgaa gctgaagtca catcctgaat gtgcatgcca   5760

gacaaagggt aagcaagcag tctttacaaa tgccaatccc tctgcactcc aaaaccggag   5820

cccgtaatga aggcccaggt tccagtcatc acaggatccc ccaagccagc acagtgcctg   5880

atgcctccct aggcattagc acatcccagc actctaattc acatcctcag catccctgcc   5940

tcctgcatcc agggcttagg ttgagtgttt ccagagtgtc aagtacattt aaacacaaac   6000

caaatactcc agggttttga cctgtcacaa tggcttttga aaacaacaga cgtacaattt   6060

gagagaagga ctcgatggac ttcttaggct gaggactaag gacatgttgc tgttcctctt   6120

ggtccaggac attcaatacc attcacagca ttcatcacca actgacatag tatcgatcac   6180

gacattcaac tgtttgaaat tactgctatt ttggtcaaaa actaagaaat cagaaattgc   6240

acctacatag tgtgtctcct cattggagtc ccatctctct gagcacaggg atgggctcct   6300

gagctcacag ccctgccctg cccccccagc agggcctcac cctcatggcc ctcagtgaat   6360

agtgactaca tgaagggggc acttactaga ggcctgagta atggaatttc aattagcttc   6420

tgcttccctt ttctaaaaaa gaaccacctt tcttaagaat aattaggcca aaataaactt   6480

gagtaatttg tacagtcaat attttgaagt ttcggagtta ccagtgaaat agcaaagctg   6540

ttctccagga aaggacatcc aggttcccac ccaggccttc cttcctcagc tcctgcagcc   6600

tcatcctagt ttaatatgaa ggttgtgaat gggttaaaaa gcagttctta agcacctact   6660

tagatctttt cagtatctgg aaatagcacc cagggctgtg ttagtaaagc ttttcactgg   6720

gtaagagtca tacaattttt acatttaatt tgttttttta aaacaaggca gtcttgtttt   6780

acatattgga atgactagat attttttgac atttctggca cctctggttc tgctgaattt   6840

taagggaggt gagtggtatg tacacaaagt taagattgct gcataataat tcctttgcat   6900

ttccaaaata aattacacaa atgtcacttt tccttttcta ttccatagta ctagttttag   6960

ccagatcttt gccaaacatt ctaggacatt cagaaaagtc atccatggaa ttttggaatg   7020

ccattctctc tgtatctttg cagatcatga ggaaggaaag ttgatgaact agtacgggat   7080

ggctcagact tgtaaagtgt ctaagtcaca acgctgcaga gccagcttcc gggtagcaat   7140

ggcatggcct cagctgtgcc aaggctacaa ctggagcttc cttactcgca tctgaggcaa   7200

acacagcaag gctggcccag gccgcccaca gtcaacagat gttcacggga gatggatcag   7260

cccctctttt gcttgttcta tcaaggaaag agatctaacc atgggcaagg gtggaacaca   7320

cccggttcag gtcagggaat gagttgctct aagtgaacag tgaattctta cttctcagcc   7380

tgtatcaatt gtacccaggg ttcatgatta ctgtgaccca ctaagggatg atctttgagg   7440

aaacagacct ggagggaggt aatttaagga gggaaagcga gtgggtttta cagactgctt   7500

tgtggcgaca ttcaggaaca gaccattcaa tggatgactt ttcagtacat aaaagcaagc   7560

agtaatggcc aggagagagc aaagatgccc taagaatgac atcagactga ccaaatgtgc   7620

cttttcaaat aagttatgag aacgaatgaa ttggaattag agcaaggtat tggacagaac   7680

catgctagtc tttgagagaa cgtgtggatt gggtggatgt ttggaccgaa tgaatggtaa   7740

ctttttaatg tgaaacagag aactgatata tgggctgtca tgtcacccta gggtactgtc   7800

gctctgtcat gtgtagcaat ctttccaaat ttttgttggt gggctgaaca aagataaaac   7860

taataaagta tgtgtggata ccactag                                       7887


<210>  3441
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  3441

Met Asp Leu Ala Gly Leu Leu Lys Ser Gln Phe Leu Cys His Leu Val 
1               5                   10                  15


Phe Cys Tyr Val Phe Ile Ala Ser Gly Leu Ile Ile Asn Thr Ile Gln 
            20                  25                  30


Leu Phe Thr Leu Leu Leu Trp Pro Ile Asn Lys Gln Leu Phe Arg Lys 
        35                  40                  45


Ile Asn Cys Arg Leu Ser Tyr Cys Ile Ser Ser Gln Leu Val Met Leu 
    50                  55                  60


Leu Glu Trp Trp Ser Gly Thr Glu Cys Thr Ile Phe Thr Asp Pro Arg 
65                  70                  75                  80


Ala Tyr Leu Lys Tyr Gly Lys Glu Asn Ala Ile Val Val Leu Asn His 
                85                  90                  95


Lys Phe Glu Ile Asp Phe Leu Cys Gly Trp Ser Leu Ser Glu Arg Phe 
            100                 105                 110


Gly Leu Leu Gly Gly Ser Lys Val Leu Ala Lys Lys Glu Leu Ala Tyr 
        115                 120                 125


Val Pro Ile Ile Gly Trp Met Trp Tyr Phe Thr Glu Met Val Phe Cys 
    130                 135                 140


Ser Arg Lys Trp Glu Gln Asp Arg Lys Thr Val Ala Thr Ser Leu Gln 
145                 150                 155                 160


His Leu Arg Asp Tyr Pro Glu Lys Tyr Phe Phe Leu Ile His Cys Glu 
                165                 170                 175


Gly Thr Arg Phe Thr Glu Lys Lys His Glu Ile Ser Met Gln Val Ala 
            180                 185                 190


Arg Ala Lys Gly Leu Pro Arg Leu Lys His His Leu Leu Pro Arg Thr 
        195                 200                 205


Lys Gly Phe Ala Ile Thr Val Arg Ser Leu Arg Asn Val Val Ser Ala 
    210                 215                 220


Val Tyr Asp Cys Thr Leu Asn Phe Arg Asn Asn Glu Asn Pro Thr Leu 
225                 230                 235                 240


Leu Gly Val Leu Asn Gly Lys Lys Tyr His Ala Asp Leu Tyr Val Arg 
                245                 250                 255


Arg Ile Pro Leu Glu Asp Ile Pro Glu Asp Asp Asp Glu Cys Ser Ala 
            260                 265                 270


Trp Leu His Lys Leu Tyr Gln Glu Lys Asp Ala Phe Gln Glu Glu Tyr 
        275                 280                 285


Tyr Arg Thr Gly Thr Phe Pro Glu Thr Pro Met Val Pro Pro Arg Arg 
    290                 295                 300


Pro Trp Thr Leu Val Asn Trp Leu Phe Trp Ala Ser Leu Val Leu Tyr 
305                 310                 315                 320


Pro Phe Phe Gln Phe Leu Val Ser Met Ile Arg Ser Gly Ser Ser Leu 
                325                 330                 335


Thr Leu Ala Ser Phe Ile Leu Val Phe Phe Val Ala Ser Val Gly Val 
            340                 345                 350


Arg Trp Met Ile Gly Val Thr Glu Ile Asp Lys Gly Ser Ala Tyr Gly 
        355                 360                 365


Asn Ser Asp Ser Lys Gln Lys Leu Asn Asp 
    370                 375


<210>  3442
<211>  2031
<212>  DNA
<213>  Homo sapiens

<400>  3442
ggaggtatgt ggtcctggtg ccgttcgcag gcaccttccc cgctgggtgt ggctgatgtt     60

tgcattcctc ttcccagcat atttttctct cctgggctgg atttccttag gacctctgga    120

agggacgcct tcctgagtcc tggatctttc ttccttctgg aaatctttga ctgtgggtag    180

ttatttattt ctgaataaga gcgtccacgc atcatggacc tcgcgggact gctgaagtct    240

cagttcctgt gccacctggt cttctgctac gtctttattg cctcagggct aatcatcaac    300

accattcagc tcttcactct cctcctctgg cccattaaca agcagctctt ccggaagatc    360

aactgcagac tgtcctattg catctcaagc cagctggtga tgctgctgga gtggtggtcg    420

ggcacggaat gcaccatctt cacggacccg cgcgcctacc tcaagtatgg gaaggaaaat    480

gccatcgtgg ttctcaacca caagtttgaa attgactttc tgtgtggctg gagcctgtcc    540

gaacgctttg ggctgttagg gggctccaag gtcctggcca agaaagagct ggcctatgtc    600

ccaattatcg gctggatgtg gtacttcacc gagatggtct tctgttcgcg caagtgggag    660

caggatcgca agacggttgc caccagtttg cagcacctcc gggactaccc cgagaagtat    720

tttttcctga ttcactgtga gggcacacgg ttcacggaga agaagcatga gatcagcatg    780

caggtggccc gggccaaggg gctgcctcgc ctcaagcatc acctgttgcc acgaaccaag    840

ggcttcgcca tcaccgtgag gagcttgaga aatgtagttt cagctgtata tgactgtaca    900

ctcaatttca gaaataatga aaatccaaca ctgctgggag tcctaaacgg aaagaaatac    960

catgcagatt tgtatgttag gaggatccca ctggaagaca tccctgaaga cgatgacgag   1020

tgctcggcct ggctgcacaa gctctaccag gagaaggatg cctttcagga ggagtactac   1080

aggacgggca ccttcccaga gacgcccatg gtgccccccc ggcggccctg gaccctcgtg   1140

aactggctgt tttgggcctc gctggtgctc taccctttct tccagttcct ggtcagcatg   1200

atcaggagcg ggtcttccct gacgctggcc agcttcatcc tcgtcttctt tgtggcctcc   1260

gtgggagttc gatggatgat tggtgtgacg gaaattgaca agggctctgc ctacggcaac   1320

tctgacagca agcagaaact gaatgactga ctcagggagg tgtcaccatc cgaagggaac   1380

cttggggaac tggtggcctc tgcatatcct ccttagtggg acacggtgac aaaggctggg   1440

tgagcccctg ctgggcacgg cggaagtcac gacctctcca gccagggagt ctggtctcaa   1500

ggccggatgg ggaggaagat gttttgtaat ctttttttcc ccatgtgctt tagtgggctt   1560

tggttttctt tttgtgcgag tgtgtgtgag aatggctgtg tggtgagtgt gaactttgtt   1620

ctgtgatcat agaaagggta ttttaggctg caggggaggg cagggctggg gaccgaaggg   1680

gacaagttcc cctttcatcc tttggtgctg agttttctgt aacccttggt tgccagagat   1740

aaagtgaaaa gtgctttagg tgagatgact aaattatgcc tccaagaaaa aaaaattaaa   1800

gtgcttttct gggtcatctg tggtgtatgt tgacatggac cgctgcccct ccatcctgcc   1860

cttgcccgtg gctttggtgt ttcagatcct actcacggga ggcagctgcc gcggaggtgt   1920

gggcagctga gaggggtggg caggccagca cagctcctgg caggagacac aggtccagga   1980

gcccgtgagc atttgtgaga gcagagatgg caagcacgtg cgtggagacc a            2031


<210>  3443
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  3443

Met Asp Leu Ala Gly Leu Leu Lys Ser Gln Phe Leu Cys His Leu Val 
1               5                   10                  15


Phe Cys Tyr Val Phe Ile Ala Ser Gly Leu Ile Ile Asn Thr Ile Gln 
            20                  25                  30


Leu Phe Thr Leu Leu Leu Trp Pro Ile Asn Lys Gln Leu Phe Arg Lys 
        35                  40                  45


Ile Asn Cys Arg Leu Ser Tyr Cys Ile Ser Ser Gln Leu Val Met Leu 
    50                  55                  60


Leu Glu Trp Trp Ser Gly Thr Glu Cys Thr Ile Phe Thr Asp Pro Arg 
65                  70                  75                  80


Ala Tyr Leu Lys Tyr Gly Lys Glu Asn Ala Ile Val Val Leu Asn His 
                85                  90                  95


Lys Phe Glu Ile Asp Phe Leu Cys Gly Trp Ser Leu Ser Glu Arg Phe 
            100                 105                 110


Gly Leu Leu Gly Gly Ser Lys Val Leu Ala Lys Lys Glu Leu Ala Tyr 
        115                 120                 125


Val Pro Ile Ile Gly Trp Met Trp Tyr Phe Thr Glu Met Val Phe Cys 
    130                 135                 140


Ser Arg Lys Trp Glu Gln Asp Arg Lys Thr Val Ala Thr Ser Leu Gln 
145                 150                 155                 160


His Leu Arg Asp Tyr Pro Glu Lys Tyr Phe Phe Leu Ile His Cys Glu 
                165                 170                 175


Gly Thr Arg Phe Thr Glu Lys Lys His Glu Ile Ser Met Gln Val Ala 
            180                 185                 190


Arg Ala Lys Gly Leu Pro Arg Leu Lys His His Leu Leu Pro Arg Thr 
        195                 200                 205


Lys Gly Phe Ala Ile Thr Val Arg Ser Leu Arg Asn Val Val Ser Ala 
    210                 215                 220


Val Tyr Asp Cys Thr Leu Asn Phe Arg Asn Asn Glu Asn Pro Thr Leu 
225                 230                 235                 240


Leu Gly Val Leu Asn Gly Lys Lys Tyr His Ala Asp Leu Tyr Val Arg 
                245                 250                 255


Arg Ile Pro Leu Glu Asp Ile Pro Glu Asp Asp Asp Glu Cys Ser Ala 
            260                 265                 270


Trp Leu His Lys Leu Tyr Gln Glu Lys Asp Ala Phe Gln Glu Glu Tyr 
        275                 280                 285


Tyr Arg Thr Gly Thr Phe Pro Glu Thr Pro Met Val Pro Pro Arg Arg 
    290                 295                 300


Pro Trp Thr Leu Val Asn Trp Leu Phe Trp Ala Ser Leu Val Leu Tyr 
305                 310                 315                 320


Pro Phe Phe Gln Phe Leu Val Ser Met Ile Arg Ser Gly Ser Ser Leu 
                325                 330                 335


Thr Leu Ala Ser Phe Ile Leu Val Phe Phe Val Ala Ser Val Gly Val 
            340                 345                 350


Arg Trp Met Ile Gly Val Thr Glu Ile Asp Lys Gly Ser Ala Tyr Gly 
        355                 360                 365


Asn Ser Asp Ser Lys Gln Lys Leu Asn Asp 
    370                 375


<210>  3444
<211>  1442
<212>  DNA
<213>  Homo sapiens

<400>  3444
gctttttctt tccagtgttg gctgacttac agctcttata aactagtggc aatttctgaa     60

cccagccggc tccatctcag cttctggttt ctaagtccat gtgccaaagg ctgccaggaa    120

ggagacgcct tcctgagtcc tggatctttc ttccttctgg aaatctttga ctgtgggtag    180

ttatttattt ctgaataaga gcgtccacgc atcatggacc tcgcgggact gctgaagtct    240

cagttcctgt gccacctggt cttctgctac gtctttattg cctcagggct aatcatcaac    300

accattcagc tcttcactct cctcctctgg cccattaaca agcagctctt ccggaagatc    360

aactgcagac tgtcctattg catctcaagc cgaggatccc actggaagac atccctgaag    420

acgatgacga gtgctcggcc tggctgcaca agctctacca ggagaaggat gcctttcagg    480

aggagtacta caggacgggc accttcccag agacgcccat ggtgcccccc cggcggccct    540

ggaccctcgt gaactggctg ttttgggcct cgctggtgct ctaccctttc ttccagttcc    600

tggtcagcat gatcaggagc gggtcttccc tgacgctggc cagcttcatc ctcgtcttct    660

ttgtggcctc cgtgggagtt cgatggatga ttggtgtgac ggaaattgac aagggctctg    720

cctacggcaa ctctgacagc aagcagaaac tgaatgactg actcagggag gtgtcaccat    780

ccgaagggaa ccttggggaa ctggtggcct ctgcatatcc tccttagtgg gacacggtga    840

caaaggctgg gtgagcccct gctgggcacg gcggaagtca cgacctctcc agccagggag    900

tctggtctca aggccggatg gggaggaaga tgttttgtaa tctttttttc cccatgtgct    960

ttagtgggct ttggttttct ttttgtgcga gtgtgtgtga gaatggctgt gtggtgagtg   1020

tgaactttgt tctgtgatca tagaaagggt attttaggct gcaggggagg gcagggctgg   1080

ggaccgaagg ggacaagttc ccctttcatc ctttggtgct gagttttctg taacccttgg   1140

ttgccagaga taaagtgaaa agtgctttag gtgagatgac taaattatgc ctccaagaaa   1200

aaaaaattaa agtgcttttc tgggtcatct gtggtgtatg ttgacatgga ccgctgcccc   1260

tccatcctgc ccttgcccgt ggctttggtg tttcagatcc tactcacggg aggcagctgc   1320

cgcggaggtg tgggcagctg agaggggtgg gcaggccagc acagctcctg gcaggagaca   1380

caggtccagg agcccgtgag catttgtgag agcagagatg gcaagcacgt gcgtggagac   1440

ca                                                                  1442


<210>  3445
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  3445

Met Asp Leu Ala Gly Leu Leu Lys Ser Gln Phe Leu Cys His Leu Val 
1               5                   10                  15


Phe Cys Tyr Val Phe Ile Ala Ser Gly Leu Ile Ile Asn Thr Ile Gln 
            20                  25                  30


Leu Phe Thr Leu Leu Leu Trp Pro Ile Asn Lys Gln Leu Phe Arg Lys 
        35                  40                  45


Ile Asn Cys Arg Leu Ser Tyr Cys Ile Ser Ser Arg Gly Ser His Trp 
    50                  55                  60


Lys Thr Ser Leu Lys Thr Met Thr Ser Ala Arg Pro Gly Cys Thr Ser 
65                  70                  75                  80


Ser Thr Arg Arg Arg Met Pro Phe Arg Arg Ser Thr Thr Gly Arg Ala 
                85                  90                  95


Pro Ser Gln Arg Arg Pro Trp Cys Pro Pro Gly Gly Pro Gly Pro Ser 
            100                 105                 110


<210>  3446
<211>  1815
<212>  DNA
<213>  Homo sapiens

<400>  3446
ggaggtatgt ggtcctggtg ccgttcgcag gcaccttccc cgctgggtgt ggctgatgtt     60

tgcattcctc ttcccagcat atttttctct cctgggctgg atttccttag gacctctgga    120

agggacgcct tcctgagtcc tggatctttc ttccttctgg aaatctttga ctgtgggtag    180

ttatttattt ctgaataaga gcgtccacgc atcatggacc tcgcgggact gctgaagtct    240

cagttcctgt gccacctggt cttctgctac gtctttattg cctcagggct aatcatcaac    300

accattcagc tcttcactct cctcctctgg cccattaaca agcagctctt ccggaagatc    360

aactgcagac tgtcctattg catctcaagc cagctggtga tgctgctgga gtggtggtcg    420

ggcacggaat gcaccatctt cacggacccg cgcgcctacc tcaagtatgg gaaggaaaat    480

gccatcgtgg ttctcaacca caagtttgaa attgactttc tgtgtggctg gagcctgtcc    540

gaacgctttg ggctgttagg gggctccaag gtcctggcca agaaagagct ggcctatgtc    600

ccaattatcg gctggatgtg gtacttcacc gagatggtct tctgttcgcg caagtgggag    660

caggatcgca agacggttgc caccagtttg cagcacctcc gggactaccc cgagaagtat    720

tttttcctga ttcactgtga gggcacacgg ttcacggaga agaagcatga gatcagcatg    780

caggtggccc gggccaaggg gctgcctcgc ctcaagcatc acctgttgcc acgaaccaag    840

ggcttcgcca tcaccgtgag gagcttgaga aatgtagttt cagctgtata tgactgtaca    900

ctcaatttca gaaataatga aaatccaaca ctgctgggag tcctaaacgg aaagaaatac    960

catgcagatt tgtatgttag gaggatccca ctggaagaca tccctgaaga cgatgacgag   1020

tgctcggcct ggctgcacaa gctctaccag gagaaggatg cctttcagga ggagtactac   1080

aggacgggca ccttcccaga gacgcccatg gtgccccccc ggcggccctg gaccctcgtg   1140

aactggctgt tttgggcctc gctggtgctc taccctttct tccagttcct ggtcagcatg   1200

atcaggagcg ggtcttccct gacgctggcc agcttcatcc tcgtcttctt tgtggcctcc   1260

gtgggagttc gatggatgat tggtgtgacg gaaattgaca agggctctgc ctacggcaac   1320

tctgacagca agcagaaact gaatgactga ctcagggagg tgtcaccatc cgaagggaac   1380

cttggggaac tggtggcctc tgcatatcct ccttagtggg acacggtgac aaaggctggg   1440

tgagcccctg ctgggcacgg cggaagtcac gacctctcca gccagggagt ctggtctcaa   1500

ggccggatgg ggaggaagat gttttgtaat ctttttttcc ccatgtgctt tagtgggctt   1560

tggttttctt tttgtgcgag tgtgtgtgag aatggctgtg tggtgagtgt gaactttgtt   1620

ctgtgatcat agaaagggta ttttaggctg caggggaggg cagggctggg gaccgaaggg   1680

gacaagttcc cctttcatcc tttggtgctg agttttctgt aacccttggt tgccagagat   1740

aaagtgaaaa gtgctttagg tgagatgact aaattatgcc tccaagaaaa aaaaattaaa   1800

gtgcttttct gggtc                                                    1815


<210>  3447
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  3447

Met Asp Leu Ala Gly Leu Leu Lys Ser Gln Phe Leu Cys His Leu Val 
1               5                   10                  15


Phe Cys Tyr Val Phe Ile Ala Ser Gly Leu Ile Ile Asn Thr Ile Gln 
            20                  25                  30


Leu Phe Thr Leu Leu Leu Trp Pro Ile Asn Lys Gln Leu Phe Arg Lys 
        35                  40                  45


Ile Asn Cys Arg Leu Ser Tyr Cys Ile Ser Ser Gln Leu Val Met Leu 
    50                  55                  60


Leu Glu Trp Trp Ser Gly Thr Glu Cys Thr Ile Phe Thr Asp Pro Arg 
65                  70                  75                  80


Ala Tyr Leu Lys Tyr Gly Lys Glu Asn Ala Ile Val Val Leu Asn His 
                85                  90                  95


Lys Phe Glu Ile Asp Phe Leu Cys Gly Trp Ser Leu Ser Glu Arg Phe 
            100                 105                 110


Gly Leu Leu Gly Gly Ser Lys Val Leu Ala Lys Lys Glu Leu Ala Tyr 
        115                 120                 125


Val Pro Ile Ile Gly Trp Met Trp Tyr Phe Thr Glu Met Val Phe Cys 
    130                 135                 140


Ser Arg Lys Trp Glu Gln Asp Arg Lys Thr Val Ala Thr Ser Leu Gln 
145                 150                 155                 160


His Leu Arg Asp Tyr Pro Glu Lys Tyr Phe Phe Leu Ile His Cys Glu 
                165                 170                 175


Gly Thr Arg Phe Thr Glu Lys Lys His Glu Ile Ser Met Gln Val Ala 
            180                 185                 190


Arg Ala Lys Gly Leu Pro Arg Leu Lys His His Leu Leu Pro Arg Thr 
        195                 200                 205


Lys Gly Phe Ala Ile Thr Val Arg Ser Leu Arg Asn Val Val Ser Ala 
    210                 215                 220


Val Tyr Asp Cys Thr Leu Asn Phe Arg Asn Asn Glu Asn Pro Thr Leu 
225                 230                 235                 240


Leu Gly Val Leu Asn Gly Lys Lys Tyr His Ala Asp Leu Tyr Val Arg 
                245                 250                 255


Arg Ile Pro Leu Glu Asp Ile Pro Glu Asp Asp Asp Glu Cys Ser Ala 
            260                 265                 270


Trp Leu His Lys Leu Tyr Gln Glu Lys Asp Ala Phe Gln Glu Glu Tyr 
        275                 280                 285


Tyr Arg Thr Gly Thr Phe Pro Glu Thr Pro Met Val Pro Pro Arg Arg 
    290                 295                 300


Pro Trp Thr Leu Val Asn Trp Leu Phe Trp Ala Ser Leu Val Leu Tyr 
305                 310                 315                 320


Pro Phe Phe Gln Phe Leu Val Ser Met Ile Arg Ser Gly Ser Ser Leu 
                325                 330                 335


Thr Leu Ala Ser Phe Ile Leu Val Phe Phe Val Ala Ser Val Gly Val 
            340                 345                 350


Arg Trp Met Ile Gly Val Thr Glu Ile Asp Lys Gly Ser Ala Tyr Gly 
        355                 360                 365


Asn Ser Asp Ser Lys Gln Lys Leu Asn Asp 
    370                 375


<210>  3448
<211>  1226
<212>  DNA
<213>  Homo sapiens

<400>  3448
gctttttctt tccagtgttg gctgacttac agctcttata aactagtggc aatttctgaa     60

cccagccggc tccatctcag cttctggttt ctaagtccat gtgccaaagg ctgccaggaa    120

ggagacgcct tcctgagtcc tggatctttc ttccttctgg aaatctttga ctgtgggtag    180

ttatttattt ctgaataaga gcgtccacgc atcatggacc tcgcgggact gctgaagtct    240

cagttcctgt gccacctggt cttctgctac gtctttattg cctcagggct aatcatcaac    300

accattcagc tcttcactct cctcctctgg cccattaaca agcagctctt ccggaagatc    360

aactgcagac tgtcctattg catctcaagc cgaggatccc actggaagac atccctgaag    420

acgatgacga gtgctcggcc tggctgcaca agctctacca ggagaaggat gcctttcagg    480

aggagtacta caggacgggc accttcccag agacgcccat ggtgcccccc cggcggccct    540

ggaccctcgt gaactggctg ttttgggcct cgctggtgct ctaccctttc ttccagttcc    600

tggtcagcat gatcaggagc gggtcttccc tgacgctggc cagcttcatc ctcgtcttct    660

ttgtggcctc cgtgggagtt cgatggatga ttggtgtgac ggaaattgac aagggctctg    720

cctacggcaa ctctgacagc aagcagaaac tgaatgactg actcagggag gtgtcaccat    780

ccgaagggaa ccttggggaa ctggtggcct ctgcatatcc tccttagtgg gacacggtga    840

caaaggctgg gtgagcccct gctgggcacg gcggaagtca cgacctctcc agccagggag    900

tctggtctca aggccggatg gggaggaaga tgttttgtaa tctttttttc cccatgtgct    960

ttagtgggct ttggttttct ttttgtgcga gtgtgtgtga gaatggctgt gtggtgagtg   1020

tgaactttgt tctgtgatca tagaaagggt attttaggct gcaggggagg gcagggctgg   1080

ggaccgaagg ggacaagttc ccctttcatc ctttggtgct gagttttctg taacccttgg   1140

ttgccagaga taaagtgaaa agtgctttag gtgagatgac taaattatgc ctccaagaaa   1200

aaaaaattaa agtgcttttc tgggtc                                        1226


<210>  3449
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  3449

Met Asp Leu Ala Gly Leu Leu Lys Ser Gln Phe Leu Cys His Leu Val 
1               5                   10                  15


Phe Cys Tyr Val Phe Ile Ala Ser Gly Leu Ile Ile Asn Thr Ile Gln 
            20                  25                  30


Leu Phe Thr Leu Leu Leu Trp Pro Ile Asn Lys Gln Leu Phe Arg Lys 
        35                  40                  45


Ile Asn Cys Arg Leu Ser Tyr Cys Ile Ser Ser Arg Gly Ser His Trp 
    50                  55                  60


Lys Thr Ser Leu Lys Thr Met Thr Ser Ala Arg Pro Gly Cys Thr Ser 
65                  70                  75                  80


Ser Thr Arg Arg Arg Met Pro Phe Arg Arg Ser Thr Thr Gly Arg Ala 
                85                  90                  95


Pro Ser Gln Arg Arg Pro Trp Cys Pro Pro Gly Gly Pro Gly Pro Ser 
            100                 105                 110


<210>  3450
<211>  1838
<212>  DNA
<213>  Homo sapiens

<400>  3450
gtccacccca tgggtggagt ctcgcttttt ctttccagtg ttggctgact tacagctctt     60

ataaactagt ggcaatttct gaacccagcc ggctccatct cagcttctgg tttctaagtc    120

catgtgccaa aggctgccag gaaggagacg ccttcctgag tcctggatct ttcttccttc    180

tggaaatctt tgactgtggg tagttattta tttctgaata agagcgtcca cgcatcatgg    240

acctcgcggg actgctgaag tctcagttcc tgtgccacct ggtcttctgc tacgtcttta    300

ttgcctcagg gctaatcatc aacaccattc agctcttcac tctcctcctc tggcccatta    360

acaagcagct cttccggaag atcaactgca gactgtccta ttgcatctca agccagctgg    420

tgatgctgct ggagtggtgg tcgggcacgg aatgcaccat cttcacggac ccgcgcgcct    480

acctcaagta tgggaaggaa aatgccatcg tggttctcaa ccacaagttt gaaattgact    540

ttctgtgtgg ctggagcctg tccgaacgct ttgggctgtt agggggctcc aaggtcctgg    600

ccaagaaaga gctggcctat gtcccaatta tcggctggat gtggtacttc accgagatgg    660

tcttctgttc gcgcaagtgg gagcaggatc gcaagacggt tgccaccagt ttgcagcacc    720

tccgggacta ccccgagaag tattttttcc tgattcactg tgagggcaca cggttcacgg    780

agaagaagca tgagatcagc atgcaggtgg cccgggccaa ggggctgcct cgcctcaagc    840

atcacctgtt gccacgaacc aagggcttcg ccatcaccgt gaggagcttg agaaatgtag    900

tttcagctgt atatgactgt acactcaatt tcagaaataa tgaaaatcca acactgctgg    960

gagtcctaaa cggaaagaaa taccatgcag atttgtatgt taggaggatc ccactggaag   1020

acatccctga agacgatgac gagtgctcgg cctggctgca caagctctac caggagaagg   1080

atgcctttca ggaggagtac tacaggacgg gcaccttccc agagacgccc atggtgcccc   1140

cccggcggcc ctggaccctc gtgaactggc tgttttgggc ctcgctggtg ctctaccctt   1200

tcttccagtt cctggtcagc atgatcagga gcgggtcttc cctgacgctg gccagcttca   1260

tcctcgtctt ctttgtggcc tccgtgggag ttcgatggat gattggtgtg acggaaattg   1320

acaagggctc tgcctacggc aactctgaca gcaagcagaa actgaatgac tgactcaggg   1380

aggtgtcacc atccgaaggg aaccttgggg aactggtggc ctctgcatat cctccttagt   1440

gggacacggt gacaaaggct gggtgagccc ctgctgggca cggcggaagt cacgacctct   1500

ccagccaggg agtctggtct caaggccgga tggggaggaa gatgttttgt aatctttttt   1560

tccccatgtg ctttagtggg ctttggtttt ctttttgtgc gagtgtgtgt gagaatggct   1620

gtgtggtgag tgtgaacttt gttctgtgat catagaaagg gtattttagg ctgcagggga   1680

gggcagggct ggggaccgaa ggggacaagt tcccctttca tcctttggtg ctgagttttc   1740

tgtaaccctt ggttgccaga gataaagtga aaagtgcttt aggtgagatg actaaattat   1800

gcctccaaga aaaaaaaatt aaagtgcttt tctgggtc                           1838


<210>  3451
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  3451

Met Asp Leu Ala Gly Leu Leu Lys Ser Gln Phe Leu Cys His Leu Val 
1               5                   10                  15


Phe Cys Tyr Val Phe Ile Ala Ser Gly Leu Ile Ile Asn Thr Ile Gln 
            20                  25                  30


Leu Phe Thr Leu Leu Leu Trp Pro Ile Asn Lys Gln Leu Phe Arg Lys 
        35                  40                  45


Ile Asn Cys Arg Leu Ser Tyr Cys Ile Ser Ser Gln Leu Val Met Leu 
    50                  55                  60


Leu Glu Trp Trp Ser Gly Thr Glu Cys Thr Ile Phe Thr Asp Pro Arg 
65                  70                  75                  80


Ala Tyr Leu Lys Tyr Gly Lys Glu Asn Ala Ile Val Val Leu Asn His 
                85                  90                  95


Lys Phe Glu Ile Asp Phe Leu Cys Gly Trp Ser Leu Ser Glu Arg Phe 
            100                 105                 110


Gly Leu Leu Gly Gly Ser Lys Val Leu Ala Lys Lys Glu Leu Ala Tyr 
        115                 120                 125


Val Pro Ile Ile Gly Trp Met Trp Tyr Phe Thr Glu Met Val Phe Cys 
    130                 135                 140


Ser Arg Lys Trp Glu Gln Asp Arg Lys Thr Val Ala Thr Ser Leu Gln 
145                 150                 155                 160


His Leu Arg Asp Tyr Pro Glu Lys Tyr Phe Phe Leu Ile His Cys Glu 
                165                 170                 175


Gly Thr Arg Phe Thr Glu Lys Lys His Glu Ile Ser Met Gln Val Ala 
            180                 185                 190


Arg Ala Lys Gly Leu Pro Arg Leu Lys His His Leu Leu Pro Arg Thr 
        195                 200                 205


Lys Gly Phe Ala Ile Thr Val Arg Ser Leu Arg Asn Val Val Ser Ala 
    210                 215                 220


Val Tyr Asp Cys Thr Leu Asn Phe Arg Asn Asn Glu Asn Pro Thr Leu 
225                 230                 235                 240


Leu Gly Val Leu Asn Gly Lys Lys Tyr His Ala Asp Leu Tyr Val Arg 
                245                 250                 255


Arg Ile Pro Leu Glu Asp Ile Pro Glu Asp Asp Asp Glu Cys Ser Ala 
            260                 265                 270


Trp Leu His Lys Leu Tyr Gln Glu Lys Asp Ala Phe Gln Glu Glu Tyr 
        275                 280                 285


Tyr Arg Thr Gly Thr Phe Pro Glu Thr Pro Met Val Pro Pro Arg Arg 
    290                 295                 300


Pro Trp Thr Leu Val Asn Trp Leu Phe Trp Ala Ser Leu Val Leu Tyr 
305                 310                 315                 320


Pro Phe Phe Gln Phe Leu Val Ser Met Ile Arg Ser Gly Ser Ser Leu 
                325                 330                 335


Thr Leu Ala Ser Phe Ile Leu Val Phe Phe Val Ala Ser Val Gly Val 
            340                 345                 350


Arg Trp Met Ile Gly Val Thr Glu Ile Asp Lys Gly Ser Ala Tyr Gly 
        355                 360                 365


Asn Ser Asp Ser Lys Gln Lys Leu Asn Asp 
    370                 375


<210>  3452
<211>  1181
<212>  DNA
<213>  Homo sapiens

<400>  3452
gctttttctt tccagtgttg gctgacttac agctcttata aactagtggc aatttctgaa     60

cccagccggc tccatctcag cttctggttt ctaagtccat gtgccaaagg ctgccaggaa    120

ggagacgcct tcctgagtcc tggatctttc ttccttctgg aaatctttga ctgtgggtag    180

ttatttattt ctgaataaga gcgtccacgc atcatggacc tcgcgggact gctgaagtct    240

cagttcctgt gccacctggt cttctgctac gtctttattg cctcagggct aatcatcaac    300

accattcagc tcttcactct cctcctctgg cccattaaca agcagctctt ccggaagatc    360

aactgcagac tgtcctattg catctcaagc cgaggatccc actggaagac atccctgaag    420

acgatgacga gtgctcggcc tggctgcaca agctctacca ggagaaggat gcctttcagg    480

aggagtacta caggacgggc accttcccag agacgcccat ggtgcccccc cggcggccct    540

ggaccctcgt gaactggctg ttttgggcct cgctggtgct ctaccctttc ttccagttcc    600

tggtcagcat gatcaggagc gggtcttccc tgacgctggc cagcttcatc ctcgtcttct    660

ttgtggcctc cgtgggagtt cgatggatga ttggtgtgac ggaaattgac aagggctctg    720

cctacggcaa ctctgacagc aagcagaaac tgaatgactg actcagggag gtgtcaccat    780

ccgaagggaa ccttggggaa ctggtggcct ctgcatatcc tccttagtgg gacacggtga    840

caaaggctgg gtgagcccct gctgggcacg gcggaagtca cgacctctcc agccagggag    900

tctggtctca aggccggatg gggaggaaga tgttttgtaa tctttttttc cccatgtgct    960

ttagtgggct ttggttttct ttttgtgcga gtgtgtgtga gaatggctgt gtggtgagtg   1020

tgaactttgt tctgtgatca tagaaagggt attttaggct gcaggggagg gcagggctgg   1080

ggaccgaagg ggacaagttc ccctttcatc ctttggtgct gagttttctg taacccttgg   1140

ttgccagaga taaagtgaaa agtgctttag gtgagatgac t                       1181


<210>  3453
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  3453

Met Asp Leu Ala Gly Leu Leu Lys Ser Gln Phe Leu Cys His Leu Val 
1               5                   10                  15


Phe Cys Tyr Val Phe Ile Ala Ser Gly Leu Ile Ile Asn Thr Ile Gln 
            20                  25                  30


Leu Phe Thr Leu Leu Leu Trp Pro Ile Asn Lys Gln Leu Phe Arg Lys 
        35                  40                  45


Ile Asn Cys Arg Leu Ser Tyr Cys Ile Ser Ser Arg Gly Ser His Trp 
    50                  55                  60


Lys Thr Ser Leu Lys Thr Met Thr Ser Ala Arg Pro Gly Cys Thr Ser 
65                  70                  75                  80


Ser Thr Arg Arg Arg Met Pro Phe Arg Arg Ser Thr Thr Gly Arg Ala 
                85                  90                  95


Pro Ser Gln Arg Arg Pro Trp Cys Pro Pro Gly Gly Pro Gly Pro Ser 
            100                 105                 110


<210>  3454
<211>  1793
<212>  DNA
<213>  Homo sapiens

<400>  3454
gtccacccca tgggtggagt ctcgcttttt ctttccagtg ttggctgact tacagctctt     60

ataaactagt ggcaatttct gaacccagcc ggctccatct cagcttctgg tttctaagtc    120

catgtgccaa aggctgccag gaaggagacg ccttcctgag tcctggatct ttcttccttc    180

tggaaatctt tgactgtggg tagttattta tttctgaata agagcgtcca cgcatcatgg    240

acctcgcggg actgctgaag tctcagttcc tgtgccacct ggtcttctgc tacgtcttta    300

ttgcctcagg gctaatcatc aacaccattc agctcttcac tctcctcctc tggcccatta    360

acaagcagct cttccggaag atcaactgca gactgtccta ttgcatctca agccagctgg    420

tgatgctgct ggagtggtgg tcgggcacgg aatgcaccat cttcacggac ccgcgcgcct    480

acctcaagta tgggaaggaa aatgccatcg tggttctcaa ccacaagttt gaaattgact    540

ttctgtgtgg ctggagcctg tccgaacgct ttgggctgtt agggggctcc aaggtcctgg    600

ccaagaaaga gctggcctat gtcccaatta tcggctggat gtggtacttc accgagatgg    660

tcttctgttc gcgcaagtgg gagcaggatc gcaagacggt tgccaccagt ttgcagcacc    720

tccgggacta ccccgagaag tattttttcc tgattcactg tgagggcaca cggttcacgg    780

agaagaagca tgagatcagc atgcaggtgg cccgggccaa ggggctgcct cgcctcaagc    840

atcacctgtt gccacgaacc aagggcttcg ccatcaccgt gaggagcttg agaaatgtag    900

tttcagctgt atatgactgt acactcaatt tcagaaataa tgaaaatcca acactgctgg    960

gagtcctaaa cggaaagaaa taccatgcag atttgtatgt taggaggatc ccactggaag   1020

acatccctga agacgatgac gagtgctcgg cctggctgca caagctctac caggagaagg   1080

atgcctttca ggaggagtac tacaggacgg gcaccttccc agagacgccc atggtgcccc   1140

cccggcggcc ctggaccctc gtgaactggc tgttttgggc ctcgctggtg ctctaccctt   1200

tcttccagtt cctggtcagc atgatcagga gcgggtcttc cctgacgctg gccagcttca   1260

tcctcgtctt ctttgtggcc tccgtgggag ttcgatggat gattggtgtg acggaaattg   1320

acaagggctc tgcctacggc aactctgaca gcaagcagaa actgaatgac tgactcaggg   1380

aggtgtcacc atccgaaggg aaccttgggg aactggtggc ctctgcatat cctccttagt   1440

gggacacggt gacaaaggct gggtgagccc ctgctgggca cggcggaagt cacgacctct   1500

ccagccaggg agtctggtct caaggccgga tggggaggaa gatgttttgt aatctttttt   1560

tccccatgtg ctttagtggg ctttggtttt ctttttgtgc gagtgtgtgt gagaatggct   1620

gtgtggtgag tgtgaacttt gttctgtgat catagaaagg gtattttagg ctgcagggga   1680

gggcagggct ggggaccgaa ggggacaagt tcccctttca tcctttggtg ctgagttttc   1740

tgtaaccctt ggttgccaga gataaagtga aaagtgcttt aggtgagatg act          1793


<210>  3455
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  3455

Met Asp Leu Ala Gly Leu Leu Lys Ser Gln Phe Leu Cys His Leu Val 
1               5                   10                  15


Phe Cys Tyr Val Phe Ile Ala Ser Gly Leu Ile Ile Asn Thr Ile Gln 
            20                  25                  30


Leu Phe Thr Leu Leu Leu Trp Pro Ile Asn Lys Gln Leu Phe Arg Lys 
        35                  40                  45


Ile Asn Cys Arg Leu Ser Tyr Cys Ile Ser Ser Gln Leu Val Met Leu 
    50                  55                  60


Leu Glu Trp Trp Ser Gly Thr Glu Cys Thr Ile Phe Thr Asp Pro Arg 
65                  70                  75                  80


Ala Tyr Leu Lys Tyr Gly Lys Glu Asn Ala Ile Val Val Leu Asn His 
                85                  90                  95


Lys Phe Glu Ile Asp Phe Leu Cys Gly Trp Ser Leu Ser Glu Arg Phe 
            100                 105                 110


Gly Leu Leu Gly Gly Ser Lys Val Leu Ala Lys Lys Glu Leu Ala Tyr 
        115                 120                 125


Val Pro Ile Ile Gly Trp Met Trp Tyr Phe Thr Glu Met Val Phe Cys 
    130                 135                 140


Ser Arg Lys Trp Glu Gln Asp Arg Lys Thr Val Ala Thr Ser Leu Gln 
145                 150                 155                 160


His Leu Arg Asp Tyr Pro Glu Lys Tyr Phe Phe Leu Ile His Cys Glu 
                165                 170                 175


Gly Thr Arg Phe Thr Glu Lys Lys His Glu Ile Ser Met Gln Val Ala 
            180                 185                 190


Arg Ala Lys Gly Leu Pro Arg Leu Lys His His Leu Leu Pro Arg Thr 
        195                 200                 205


Lys Gly Phe Ala Ile Thr Val Arg Ser Leu Arg Asn Val Val Ser Ala 
    210                 215                 220


Val Tyr Asp Cys Thr Leu Asn Phe Arg Asn Asn Glu Asn Pro Thr Leu 
225                 230                 235                 240


Leu Gly Val Leu Asn Gly Lys Lys Tyr His Ala Asp Leu Tyr Val Arg 
                245                 250                 255


Arg Ile Pro Leu Glu Asp Ile Pro Glu Asp Asp Asp Glu Cys Ser Ala 
            260                 265                 270


Trp Leu His Lys Leu Tyr Gln Glu Lys Asp Ala Phe Gln Glu Glu Tyr 
        275                 280                 285


Tyr Arg Thr Gly Thr Phe Pro Glu Thr Pro Met Val Pro Pro Arg Arg 
    290                 295                 300


Pro Trp Thr Leu Val Asn Trp Leu Phe Trp Ala Ser Leu Val Leu Tyr 
305                 310                 315                 320


Pro Phe Phe Gln Phe Leu Val Ser Met Ile Arg Ser Gly Ser Ser Leu 
                325                 330                 335


Thr Leu Ala Ser Phe Ile Leu Val Phe Phe Val Ala Ser Val Gly Val 
            340                 345                 350


Arg Trp Met Ile Gly Val Thr Glu Ile Asp Lys Gly Ser Ala Tyr Gly 
        355                 360                 365


Asn Ser Asp Ser Lys Gln Lys Leu Asn Asp 
    370                 375


<210>  3456
<211>  1224
<212>  DNA
<213>  Homo sapiens

<400>  3456
tctcgctttt tctttccagt gttggctgac ttacagctct tataaactag tggcaatttc     60

tgaacccagc cggctccatc tcagcttctg gtttctaagt ccatgtgcca aaggctgcca    120

ggaaggagac gccttcctga gtcctggatc tttcttcctt ctggaaatct ttgactgtgg    180

gtagttattt atttctgaat aagagcgtcc acgcatcatg gacctcgcgg gactgctgaa    240

gtctcagttc ctgtgccacc tggtcttctg ctacgtcttt attgcctcag ggctaatcat    300

caacaccatt cagctcttca ctctcctcct ctggcccatt aacaagcagc tcttccggaa    360

gatcaactgc agactgtcct attgcatctc aagccagctg gtgatgctgc tggagtggtg    420

gtcgggcacg gaatgcacca tcttcacgga cccgcgcgcc tacctcaagt atgggaagga    480

aaatgccatc gtggttctca accacaagtt tgaaattgac tttctgtgtg gctggagcct    540

gtccgaacgc tttgggctgt tagggggctc caaggtcctg gccaagaaag agctggccta    600

tgtcccaatt atcggctgga tgtggtactt caccgagatg gtcttctgtt cgcgcaagtg    660

ggagcaggat cgcaagacgg ttgccaccag tttgcagcac ctccgggact accccgagaa    720

gtattttgta tgtaggcacc agagcagctg tgtcccaagg gctcctgcag gactgtgacc    780

gtgggacccc catgtgactt ccacaggaca cgtgactgtg tggtcctgtg cgactccagg    840

gctgtgtgtg accatagggc tgtgtataac ctcagggatg tatgtgacca tggggccgtg    900

tgtgaccgtg gggccacgta tgactgtggg gccgtgtatg accatggggc cgtgtgtgac    960

cccagggctg tgtgtgaccc cagggctgtg tgtgaccatg gggccgtgtg tgatcatgtg   1020

gccatatgtg accctggggc tatgtgtgac cccagggctg tgtgtgaccc cagggctatg   1080

tgtgacctca gggctgtatg taaccatggg gccctgtgtg atcgtgtggc catatgtgcc   1140

cctggggctg tgtgtgaccc cagggccagg catgacacca gggctgtgtg tgaccccagg   1200

gctgtatgtg accccagggc tgtg                                          1224


<210>  3457
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  3457

Met Asp Leu Ala Gly Leu Leu Lys Ser Gln Phe Leu Cys His Leu Val 
1               5                   10                  15


Phe Cys Tyr Val Phe Ile Ala Ser Gly Leu Ile Ile Asn Thr Ile Gln 
            20                  25                  30


Leu Phe Thr Leu Leu Leu Trp Pro Ile Asn Lys Gln Leu Phe Arg Lys 
        35                  40                  45


Ile Asn Cys Arg Leu Ser Tyr Cys Ile Ser Ser Gln Leu Val Met Leu 
    50                  55                  60


Leu Glu Trp Trp Ser Gly Thr Glu Cys Thr Ile Phe Thr Asp Pro Arg 
65                  70                  75                  80


Ala Tyr Leu Lys Tyr Gly Lys Glu Asn Ala Ile Val Val Leu Asn His 
                85                  90                  95


Lys Phe Glu Ile Asp Phe Leu Cys Gly Trp Ser Leu Ser Glu Arg Phe 
            100                 105                 110


Gly Leu Leu Gly Gly Ser Lys Val Leu Ala Lys Lys Glu Leu Ala Tyr 
        115                 120                 125


Val Pro Ile Ile Gly Trp Met Trp Tyr Phe Thr Glu Met Val Phe Cys 
    130                 135                 140


Ser Arg Lys Trp Glu Gln Asp Arg Lys Thr Val Ala Thr Ser Leu Gln 
145                 150                 155                 160


His Leu Arg Asp Tyr Pro Glu Lys Tyr Phe Val Cys Arg His Gln Ser 
                165                 170                 175


Ser Cys Val Pro Arg Ala Pro Ala Gly Leu 
            180                 185


<210>  3458
<211>  1055
<212>  DNA
<213>  Homo sapiens

<400>  3458
gtctcgcttt ttctttccag tgttggctga cttacagctc ttataaacta gtggcaattt     60

ctgaacccag ccggctccat ctcagcttct ggtttctaag tccatgtgcc aaaggctgcc    120

aggaaggaga cgccttcctg agtcctggat ctttcttcct tctggaaatc tttgactgtg    180

ggtagttatt tatttctgaa taagagcgtc cacgcatcat ggacctcgcg ggactgctga    240

agtctcagtt cctgtgccac ctggtcttct gctacgtctt tattgcctca gggctaatca    300

tcaacaccat tcagctcttc actctcctcc tctggcccat taacaagcag ctcttccgga    360

agatcaactg cagactgtcc tattgcatct caagccggct ccaaggtcct ggccaagaaa    420

gagctggcct atgtcccaat tatcggctgg atgtggtact tcaccgagat ggtcttctgt    480

tcgcgcaagt gggagcagga tcgcaagacg gttgccacca gtttgcagca cctccgggac    540

taccccgaga agtattttgt atgtaggcac cagagcagct gtgtcccaag ggctcctgca    600

ggactgtgac cgtgggaccc ccatgtgact tccacaggac acgtgactgt gtggtcctgt    660

gcgactccag ggctgtgtgt gaccataggg ctgtgtataa cctcagggat gtatgtgacc    720

atggggccgt gtgtgaccgt ggggccacgt atgactgtgg ggccgtgtat gaccatgggg    780

ccgtgtgtga ccccagggct gtgtgtgacc ccagggctgt gtgtgaccat ggggccgtgt    840

gtgatcatgt ggccatatgt gaccctgggg ctatgtgtga ccccagggct gtgtgtgacc    900

ccagggctat gtgtgacctc agggctgtat gtaaccatgg ggccctgtgt gatcgtgtgg    960

ccatatgtgc ccctggggct gtgtgtgacc ccagggccag gcatgacacc agggctgtgt   1020

gtgaccccag ggctgtatgt gaccccaggg ctgtg                              1055


<210>  3459
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  3459

Met Asp Leu Ala Gly Leu Leu Lys Ser Gln Phe Leu Cys His Leu Val 
1               5                   10                  15


Phe Cys Tyr Val Phe Ile Ala Ser Gly Leu Ile Ile Asn Thr Ile Gln 
            20                  25                  30


Leu Phe Thr Leu Leu Leu Trp Pro Ile Asn Lys Gln Leu Phe Arg Lys 
        35                  40                  45


Ile Asn Cys Arg Leu Ser Tyr Cys Ile Ser Ser Arg Leu Gln Gly Pro 
    50                  55                  60


Gly Gln Glu Arg Ala Gly Leu Cys Pro Asn Tyr Arg Leu Asp Val Val 
65                  70                  75                  80


Leu His Arg Asp Gly Leu Leu Phe Ala Gln Val Gly Ala Gly Ser Gln 
                85                  90                  95


Asp Gly Cys His Gln Phe Ala Ala Pro Pro Gly Leu Pro Arg Glu Val 
            100                 105                 110


Phe Cys Met 
        115


<210>  3460
<211>  782
<212>  DNA
<213>  Homo sapiens

<400>  3460
gctttttctt tccagtgttg gctgacttac agctcttata aactagtggc aatttctgaa     60

cccagccggc tccatctcag cttctggttt ctaagtccat gtgccaaagg ctgccaggaa    120

ggagacgcct tcctgagtcc tggatctttc ttccttctgg aaatctttga ctgtgggtag    180

ttatttattt ctgaataaga gcgtccacgc atcatggacc tcgcgggact gctgaagtct    240

cagttcctgt gccacctggt cttctgctac gtctttattg cctcagggct aatcatcaac    300

accattcagc tcttcactct cctcctctgg cccattaaca agcagctctt ccggaagatc    360

aactgcagac tgtcctattg catctcaagc cagctggtga tgctgctgga gtggtggtcg    420

ggcacggaat gcaccatctt cacggacccg cgcgcctacc tcaagtatgg gaaggaaaat    480

gccatcgtgg ttctcaacca caagtttgaa attgactttc tgtgtggctg gagcctgtcc    540

gaacgctttg ggctgttagg ggtaagtcag aagtgcattc ccccctgcct cacacatttc    600

tctggttcag ccccaccact tgtctttttg ctcctggtca ttcagaactt gcagaagaat    660

caacagagtt tctacttgat gaaatggtcc taataaactg ctttttattc ttgctgggag    720

tcagtcttaa cagcttctta tgggcaatca taagaggtac tcaacaattg ctacctgccg    780

gc                                                                   782


<210>  3461
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  3461

Met Asp Leu Ala Gly Leu Leu Lys Ser Gln Phe Leu Cys His Leu Val 
1               5                   10                  15


Phe Cys Tyr Val Phe Ile Ala Ser Gly Leu Ile Ile Asn Thr Ile Gln 
            20                  25                  30


Leu Phe Thr Leu Leu Leu Trp Pro Ile Asn Lys Gln Leu Phe Arg Lys 
        35                  40                  45


Ile Asn Cys Arg Leu Ser Tyr Cys Ile Ser Ser Gln Leu Val Met Leu 
    50                  55                  60


Leu Glu Trp Trp Ser Gly Thr Glu Cys Thr Ile Phe Thr Asp Pro Arg 
65                  70                  75                  80


Ala Tyr Leu Lys Tyr Gly Lys Glu Asn Ala Ile Val Val Leu Asn His 
                85                  90                  95


Lys Phe Glu Ile Asp Phe Leu Cys Gly Trp Ser Leu Ser Glu Arg Phe 
            100                 105                 110


Gly Leu Leu Gly Val Ser Gln Lys Cys Ile Pro Pro Cys Leu Thr His 
        115                 120                 125


Phe Ser Gly Ser Ala Pro Pro Leu Val Phe Leu Leu Leu Val Ile Gln 
    130                 135                 140


Asn Leu Gln Lys Asn Gln Gln Ser Phe Tyr Leu Met Lys Trp Ser 
145                 150                 155


<210>  3462
<211>  718
<212>  DNA
<213>  Homo sapiens

<400>  3462
gctttttctt tccagtgttg gctgacttac agctcttata aactagtggc aatttctgaa     60

cccagccggc tccatctcag cttctggttt ctaagtccat gtgccaaagg ctgccaggaa    120

ggagacgcct tcctgagtcc tggatctttc ttccttctgg aaatctttga ctgtgggtag    180

ttatttattt ctgaataaga gcgtccacgc atcatggacc tcgcgggact gctgaagtct    240

cagttcctgt gccacctggt cttctgctac gtctttattg cctcagggct aatcatcaac    300

accattcagc tcttcactct cctcctctgg cccattaaca agcagctctt ccggaagatc    360

aactgcagac tgtcctattg catctcaagc cagctggtga tgctgctgga gtggtggtcg    420

ggcacggaat gcaccatctt cacggacccg cgcgcctacc tcaagtatgg gaaggaaaat    480

gccatcgtgg ttctcaacca caagtttgaa attgactttc tgtgtggctg gagcctgtcc    540

gaacgctttg ggctgttagg ggtaagtcag aagtgcattc ccccctgcct cacacatttc    600

tctggttcag ccccaccact tgtctttttg ctcctggtca ttcagaactt gcagaagaat    660

caacagagtt tctacttgat gaaatggtcc taataaactg ctttttattc ttgctggg      718


<210>  3463
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  3463

Met Asp Leu Ala Gly Leu Leu Lys Ser Gln Phe Leu Cys His Leu Val 
1               5                   10                  15


Phe Cys Tyr Val Phe Ile Ala Ser Gly Leu Ile Ile Asn Thr Ile Gln 
            20                  25                  30


Leu Phe Thr Leu Leu Leu Trp Pro Ile Asn Lys Gln Leu Phe Arg Lys 
        35                  40                  45


Ile Asn Cys Arg Leu Ser Tyr Cys Ile Ser Ser Gln Leu Val Met Leu 
    50                  55                  60


Leu Glu Trp Trp Ser Gly Thr Glu Cys Thr Ile Phe Thr Asp Pro Arg 
65                  70                  75                  80


Ala Tyr Leu Lys Tyr Gly Lys Glu Asn Ala Ile Val Val Leu Asn His 
                85                  90                  95


Lys Phe Glu Ile Asp Phe Leu Cys Gly Trp Ser Leu Ser Glu Arg Phe 
            100                 105                 110


Gly Leu Leu Gly Val Ser Gln Lys Cys Ile Pro Pro Cys Leu Thr His 
        115                 120                 125


Phe Ser Gly Ser Ala Pro Pro Leu Val Phe Leu Leu Leu Val Ile Gln 
    130                 135                 140


Asn Leu Gln Lys Asn Gln Gln Ser Phe Tyr Leu Met Lys Trp Ser 
145                 150                 155


<210>  3464
<211>  571
<212>  DNA
<213>  Homo sapiens

<400>  3464
gctttttctt tccagtgttg gctgacttac agctcttata aactagtggc aatttctgaa     60

cccagccggc tccatctcag cttctggttt ctaagtccat gtgccaaagg ctgccaggaa    120

ggagacgcct tcctgagtcc tggatctttc ttccttctgg aaatctttga ctgtgggtag    180

ttatttattt ctgaataaga gcgtccacgc atcatggacc tcgcgggact gctgaagtct    240

cagttcctgt gccacctggt cttctgctac gtctttattg cctcagggct aatcatcaac    300

accattcagc tcttcactct cctcctctgg cccattaaca agcagctctt ccggaagatc    360

aactgcagac tgtcctattg catctcaagc cctacacaac tgctgctgtc acccatactg    420

ttggattcca atatttcttg agacccatgg ttgggcaaac cctgccttgc atgctgtggg    480

cagcaacaac aacgaaatga acaagacaag accctgctgt tgaggaaagc acactctatg    540

gtagaagaat actgaacaag acaaaacgtg c                                   571


<210>  3465
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  3465

Met Asp Leu Ala Gly Leu Leu Lys Ser Gln Phe Leu Cys His Leu Val 
1               5                   10                  15


Phe Cys Tyr Val Phe Ile Ala Ser Gly Leu Ile Ile Asn Thr Ile Gln 
            20                  25                  30


Leu Phe Thr Leu Leu Leu Trp Pro Ile Asn Lys Gln Leu Phe Arg Lys 
        35                  40                  45


Ile Asn Cys Arg Leu Ser Tyr Cys Ile Ser Ser Pro Thr Gln Leu Leu 
    50                  55                  60


Leu Ser Pro Ile Leu Leu Asp Ser Asn Ile Ser 
65                  70                  75


<210>  3466
<211>  1112
<212>  DNA
<213>  Homo sapiens

<400>  3466
gctttttctt tccagtgttg gctgacttac agctcttata aactagtggc aatttctgaa     60

cccagccggc tccatctcag cttctggttt ctaagtccat gtgccaaagg ctgccaggaa    120

ggagacgcct tcctgagtcc tggatctttc ttccttctgg aaatctttga ctgtgggtag    180

ttatttattt ctgaataaga gcgtccacgc atcatggacc tcgcgggact gctgaagtct    240

cagttcctgt gccacctggt cttctgctac gtctttattg cctcagggct aatcatcaac    300

accattcagc tcttcactct cctcctctgg cccattaaca agcagctctt ccggaagatc    360

aactgcagac tgtcctattg catctcaagc cgtaagatac ttaagattct atattttcgt    420

ctccattgtg gatgtgtgta tcagaattat ggctcttgat atggattcac taggctttcg    480

ttgtgtgccg agctgttttt ttgttttgtt tttgttttag gtttgaaatg gctattttgt    540

tctcaatccc ccaaaattat tttttgaatg aataatgcca gtagctcaaa attcaacagc    600

cacagacagg tatactatga aaagtaaata cgcattccat tagtttcttt agttctcctc    660

agaaccaatc agtattaatg atttcttagt tatccttaca gaaatagtat acatatagct    720

cttatacttg taaatgcatg tgcgtctttc tgtgtatata tctatataga tacatataca    780

tacgtatttt tttttaaaaa actaagtggc agtatactat attgttttct tccttgcctt    840

ttttcttcag ctttttattt tgagataata gattcacatg aagctgtaac aaataatact    900

gagaaattct gtacactcct tggccagttt ctccctatgg tagcatcttg caccactgga    960

atagcatatt ccaatgagaa aattgacatt gatacaatcc acaaccctac tcctatttct   1020

ccacttttaa gtacactcat ttgtgtgtgt gtatgtgtcc gtgtatgttt gattatgcta   1080

ggttatttca tacatgacta atttgactgg cc                                 1112


<210>  3467
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  3467

Met Asp Leu Ala Gly Leu Leu Lys Ser Gln Phe Leu Cys His Leu Val 
1               5                   10                  15


Phe Cys Tyr Val Phe Ile Ala Ser Gly Leu Ile Ile Asn Thr Ile Gln 
            20                  25                  30


Leu Phe Thr Leu Leu Leu Trp Pro Ile Asn Lys Gln Leu Phe Arg Lys 
        35                  40                  45


Ile Asn Cys Arg Leu Ser Tyr Cys Ile Ser Ser Arg Lys Ile Leu Lys 
    50                  55                  60


Ile Leu Tyr Phe Arg Leu His Cys Gly Cys Val Tyr Gln Asn Tyr Gly 
65                  70                  75                  80


Ser 



<210>  3468
<211>  3827
<212>  DNA
<213>  Homo sapiens

<400>  3468
agtgtttgtc aggttcaact ccagccatgg tttcccagtg gaggtcgatt ctgacaccag     60

catcttccag ctcaaggagg tggttgctaa gcgacagggg gttccggctg accagttgcg    120

tgtgattttc gcagggaagg agctgaggaa tgactggact gtgcagcagg tagatcaatc    180

tacaacagct tttatgtgta ttgcaaaggc ccctgtcaaa gagtgcagcc gggaaaactc    240

agggtacagt gcagcacctg caggcaggca acgctcacct tgacccaggg tccatcttgc    300

tgggatgatg ttttaattcc aaaccggatg agtggtgaat gccaatcccc acactgccct    360

gggactagtg cagaattttt ctttaaatgt ggagcacacc ccacctctga caaggaaaca    420

tcagtagctt tgcacctgat cgcaacaaat agtcggaaca tcacttgcat tacgtgcaca    480

gacgtcagga gccccgtcct ggttttccag tgcaactccc gccacgtgat ttgcttagac    540

tgtttccact tatactgtgt gacaagactc aatgatcggc agtttgttca cgaccctcaa    600

cttggctact ccctgccttg tgtggctggc tgtcccaact ccttgattaa agagctccat    660

cacttcagga ttctgggaga agagcagtac aaccggtacc agcagtatgg tgcagaggag    720

tgtgtcctgc agatgggggg cgtgttatgc ccccgccctg gctgtggagc ggggctgctg    780

ccggagcctg accagaggaa agtcacctgc gaagggggca atggcctggg ctgtgggttt    840

gccttctgcc gggaatgtaa agaagcgtac catgaagggg agtgcagtgc cgtatttgaa    900

gcctcaggaa caactactca ggcctacaga gtcgatgaaa gagccgccga gcaggctcgt    960

tgggaagcag cctccaaaga aaccatcaag aaaaccacca agccctgtcc ccgctgccat   1020

gtaccagtgg aaaaaaatgg aggctgcatg cacatgaagt gtccgcagcc ccagtgcagg   1080

ctcgagtggt gctggaactg tggctgcgag tggaaccgcg tctgcatggg ggaccactgg   1140

ttcgacgtgt agccagggcg gccgggcgcc ccatcgccac atcctggggg agcataccca   1200

gtgtctacct tcattttcta attctctttt caaacacaca cacacacgcg cgcgcgcgca   1260

cacacactct tcaagttttt ttcaaagtcc aactacagcc aaattgcaga agaaactcct   1320

ggatcccttt cactatgtcc atgaaaaaca gcagagtaaa attacagaag aagctcctga   1380

atccctttca gtttgtccac acaagacagc agagccatct gcgacaccac caacaggcgt   1440

tctcagcctc cggatgacac aaataccaga gcacagattc aagtgcaatc catgtatctg   1500

tatgggtcat tctcacctga attcgagaca ggcagaatca gtagctggag agagagttct   1560

cacatttaat atcctgcctt ttaccttcag taaacaccat gaagatgcca ttgacaaggt   1620

gtttctctgt aaaatgaact gcagtgggtt ctccaaacta gattcatggc tttaacagta   1680

atgttcttat ttaaattttc agaaagcatc tattcccaaa gaaccccagg caatagtcaa   1740

aaacatttgt ttatccttaa gaattccatc tatataaatc gcattaatga aataccaact   1800

atgcgtaaat caacttgtca caaagtgaga aattatgaaa gttaatttga atgttgaatg   1860

tttgaattac agggaagaaa tcaagttaat gtactttcat tccctttcat gatttgcaac   1920

tttagaaaga aattgttttt ctgaaagtat caccaaaaaa tctatagttt gattctgagt   1980

attcattttg caacttggag attttgctaa tacatttggc tccactgtaa atttaataga   2040

taaagtgcct ataaaggaaa cacgtttaga aatgatttca aaatgatatt caatcttaac   2100

aaaagtgaac attattaaat cagaatcttt aaagaggagc ctttccagaa ctaccaaaat   2160

gaagacacgc ccgactctct ccatcagaag ggtttatacc cctttggcac accctctctg   2220

tccaatctgc aagtcccagg gagctctgca taccaggggt tccccaggag agaccttctc   2280

ttaggacagt aaactcacta gaatattcct tatgttgaca tggattggat ttcagttcaa   2340

tcaaactttc agcttttttt tcagccattc acaacacaat caaaagatta acaacactgc   2400

atgcggcaaa ccgcatgctc ttacccacac tacgcagaag agaaagtaca accactatct   2460

tttgttctac ctgtattgtc tgacttctca ggaagatcgt gaacataact gagggcatga   2520

gtctcactag cacatggagg cccttttgga tttagagact gtaaattatt aaatcggcaa   2580

cagggcttct ctttttagat gtagcactga aatccttgct ggagggaaga gaggggatga   2640

actcaagttt tccacatcct gggacacctg tccctctttt cctaactgcc taagataacc   2700

catttcttcc aaccatctga ggacagtccc gtcgtctcag aggccctgca ccggggagag   2760

actgggctct gcagcagcca catcagcatt cacagcttca tgtggcttca ctgtctgaaa   2820

atctaccgac tccaacatgg ccccacggtg acaacagacc tgtgacagga agcccaaagc   2880

tcacatagaa atggtggaca gatcaaagtc tctatagtaa gggaaaaaaa gagaggtggc   2940

aggcatgagc cccctgcacc cagtggctcg tgtccatact gagtccagac cctgatcaag   3000

gcctgactta gtgtcactgg cagtcccact aaattacact tccttacact ggcccgatgc   3060

gacaaatcag gtggctccct tctgtcacgt ggagcacaca gtgttttcca tcatccatag   3120

ctttcttcct gatggtgttt gcattattgc gccttcccaa tctgcatgct gcgttgggct   3180

tgcggtgcct gaacaaggtt tgctcccatg agctcaggca ccctaggatc ccctgttaga   3240

ctattaggct gtccagcatg gtctcctttc ccttcttggt ggtggtcttt tccctttcca   3300

gaatagaaca gtgattctta aaataagtta gagcaggccg ggcgcggtgg ctcatgcctg   3360

taatcccagc actttgggag gccgaggtgg gtggatcacg aggtcaggag ttcaagacca   3420

gcctggccaa gatgatgaaa ccccgtctct attaaaaata caaaaattag ctgggcgtgg   3480

tggcaggcac ctgtaatccc agcttcctgg gaggctgagg caggagaatc acttgaaccc   3540

ggggggcaga ggttgcagtg agccgagatc acgccactga actccagcct gggcaacaga   3600

gtgagactct gtctcaaaaa aaaaaaaaaa acaaaaacaa aaaagcaaga tcatccacta   3660

cacatgaaca tgaatcacag tattatttgc acaggaaggg tgtaacaaaa tatgaatgta   3720

tcaaaaaata gaaataaagt ctttgcagaa aaagtctgtt tttctctgaa gtgtgttgag   3780

attatctgac aactctaaga ttgtacttaa attgtcaata aagcatc                 3827


<210>  3469
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  3469

Met Ser Gly Glu Cys Gln Ser Pro His Cys Pro Gly Thr Ser Ala Glu 
1               5                   10                  15


Phe Phe Phe Lys Cys Gly Ala His Pro Thr Ser Asp Lys Glu Thr Ser 
            20                  25                  30


Val Ala Leu His Leu Ile Ala Thr Asn Ser Arg Asn Ile Thr Cys Ile 
        35                  40                  45


Thr Cys Thr Asp Val Arg Ser Pro Val Leu Val Phe Gln Cys Asn Ser 
    50                  55                  60


Arg His Val Ile Cys Leu Asp Cys Phe His Leu Tyr Cys Val Thr Arg 
65                  70                  75                  80


Leu Asn Asp Arg Gln Phe Val His Asp Pro Gln Leu Gly Tyr Ser Leu 
                85                  90                  95


Pro Cys Val Ala Gly Cys Pro Asn Ser Leu Ile Lys Glu Leu His His 
            100                 105                 110


Phe Arg Ile Leu Gly Glu Glu Gln Tyr Asn Arg Tyr Gln Gln Tyr Gly 
        115                 120                 125


Ala Glu Glu Cys Val Leu Gln Met Gly Gly Val Leu Cys Pro Arg Pro 
    130                 135                 140


Gly Cys Gly Ala Gly Leu Leu Pro Glu Pro Asp Gln Arg Lys Val Thr 
145                 150                 155                 160


Cys Glu Gly Gly Asn Gly Leu Gly Cys Gly Phe Ala Phe Cys Arg Glu 
                165                 170                 175


Cys Lys Glu Ala Tyr His Glu Gly Glu Cys Ser Ala Val Phe Glu Ala 
            180                 185                 190


Ser Gly Thr Thr Thr Gln Ala Tyr Arg Val Asp Glu Arg Ala Ala Glu 
        195                 200                 205


Gln Ala Arg Trp Glu Ala Ala Ser Lys Glu Thr Ile Lys Lys Thr Thr 
    210                 215                 220


Lys Pro Cys Pro Arg Cys His Val Pro Val Glu Lys Asn Gly Gly Cys 
225                 230                 235                 240


Met His Met Lys Cys Pro Gln Pro Gln Cys Arg Leu Glu Trp Cys Trp 
                245                 250                 255


Asn Cys Gly Cys Glu Trp Asn Arg Val Cys Met Gly Asp His Trp Phe 
            260                 265                 270


Asp Val 



<210>  3470
<211>  3873
<212>  DNA
<213>  Homo sapiens

<400>  3470
ctgaagccgg aaagggcggc ggtggggggc tgggggcagg aggcgtgagg agaaactacg     60

cgttagaact acgactccca gcaggccctg ggccgcgccc tccgcgcgtg cgcattccta    120

gggccgggcg cgggggcggg gaggcctgga ggatttaacc caggagagcc gctggtggga    180

ggcgcggctg gcgccgctgc gcgcatgggc ctgttcctgg cccgcagccg ccacctaccc    240

agtgaccatg atagtgtttg tcaggttcaa ctccagccat ggtttcccag tggaggtcga    300

ttctgacacc agcatcttcc agctcaagga ggtggttgct aagcgacagg gggttccggc    360

tgaccagttg cgtgtgattt tcgcagggaa ggagctgagg aatgactgga ctgtgcagga    420

atttttcttt aaatgtggag cacaccccac ctctgacaag gaaacatcag tagctttgca    480

cctgatcgca acaaatagtc ggaacatcac ttgcattacg tgcacagacg tcaggagccc    540

cgtcctggtt ttccagtgca actcccgcca cgtgatttgc ttagactgtt tccacttata    600

ctgtgtgaca agactcaatg atcggcagtt tgttcacgac cctcaacttg gctactccct    660

gccttgtgtg gctggctgtc ccaactcctt gattaaagag ctccatcact tcaggattct    720

gggagaagag cagtacaacc ggtaccagca gtatggtgca gaggagtgtg tcctgcagat    780

ggggggcgtg ttatgccccc gccctggctg tggagcgggg ctgctgccgg agcctgacca    840

gaggaaagtc acctgcgaag ggggcaatgg cctgggctgt gggtttgcct tctgccggga    900

atgtaaagaa gcgtaccatg aaggggagtg cagtgccgta tttgaagcct caggaacaac    960

tactcaggcc tacagagtcg atgaaagagc cgccgagcag gctcgttggg aagcagcctc   1020

caaagaaacc atcaagaaaa ccaccaagcc ctgtccccgc tgccatgtac cagtggaaaa   1080

aaatggaggc tgcatgcaca tgaagtgtcc gcagccccag tgcaggctcg agtggtgctg   1140

gaactgtggc tgcgagtgga accgcgtctg catgggggac cactggttcg acgtgtagcc   1200

agggcggccg ggcgccccat cgccacatcc tgggggagca tacccagtgt ctaccttcat   1260

tttctaattc tcttttcaaa cacacacaca cacgcgcgcg cgcgcacaca cactcttcaa   1320

gtttttttca aagtccaact acagccaaat tgcagaagaa actcctggat ccctttcact   1380

atgtccatga aaaacagcag agtaaaatta cagaagaagc tcctgaatcc ctttcagttt   1440

gtccacacaa gacagcagag ccatctgcga caccaccaac aggcgttctc agcctccgga   1500

tgacacaaat accagagcac agattcaagt gcaatccatg tatctgtatg ggtcattctc   1560

acctgaattc gagacaggca gaatcagtag ctggagagag agttctcaca tttaatatcc   1620

tgccttttac cttcagtaaa caccatgaag atgccattga caaggtgttt ctctgtaaaa   1680

tgaactgcag tgggttctcc aaactagatt catggcttta acagtaatgt tcttatttaa   1740

attttcagaa agcatctatt cccaaagaac cccaggcaat agtcaaaaac atttgtttat   1800

ccttaagaat tccatctata taaatcgcat taatgaaata ccaactatgc gtaaatcaac   1860

ttgtcacaaa gtgagaaatt atgaaagtta atttgaatgt tgaatgtttg aattacaggg   1920

aagaaatcaa gttaatgtac tttcattccc tttcatgatt tgcaacttta gaaagaaatt   1980

gtttttctga aagtatcacc aaaaaatcta tagtttgatt ctgagtattc attttgcaac   2040

ttggagattt tgctaataca tttggctcca ctgtaaattt aatagataaa gtgcctataa   2100

aggaaacacg tttagaaatg atttcaaaat gatattcaat cttaacaaaa gtgaacatta   2160

ttaaatcaga atctttaaag aggagccttt ccagaactac caaaatgaag acacgcccga   2220

ctctctccat cagaagggtt tatacccctt tggcacaccc tctctgtcca atctgcaagt   2280

cccagggagc tctgcatacc aggggttccc caggagagac cttctcttag gacagtaaac   2340

tcactagaat attccttatg ttgacatgga ttggatttca gttcaatcaa actttcagct   2400

tttttttcag ccattcacaa cacaatcaaa agattaacaa cactgcatgc ggcaaaccgc   2460

atgctcttac ccacactacg cagaagagaa agtacaacca ctatcttttg ttctacctgt   2520

attgtctgac ttctcaggaa gatcgtgaac ataactgagg gcatgagtct cactagcaca   2580

tggaggccct tttggattta gagactgtaa attattaaat cggcaacagg gcttctcttt   2640

ttagatgtag cactgaaatc cttgctggag ggaagagagg ggatgaactc aagttttcca   2700

catcctggga cacctgtccc tcttttccta actgcctaag ataacccatt tcttccaacc   2760

atctgaggac agtcccgtcg tctcagaggc cctgcaccgg ggagagactg ggctctgcag   2820

cagccacatc agcattcaca gcttcatgtg gcttcactgt ctgaaaatct accgactcca   2880

acatggcccc acggtgacaa cagacctgtg acaggaagcc caaagctcac atagaaatgg   2940

tggacagatc aaagtctcta tagtaaggga aaaaaagaga ggtggcaggc atgagccccc   3000

tgcacccagt ggctcgtgtc catactgagt ccagaccctg atcaaggcct gacttagtgt   3060

cactggcagt cccactaaat tacacttcct tacactggcc cgatgcgaca aatcaggtgg   3120

ctcccttctg tcacgtggag cacacagtgt tttccatcat ccatagcttt cttcctgatg   3180

gtgtttgcat tattgcgcct tcccaatctg catgctgcgt tgggcttgcg gtgcctgaac   3240

aaggtttgct cccatgagct caggcaccct aggatcccct gttagactat taggctgtcc   3300

agcatggtct cctttccctt cttggtggtg gtcttttccc tttccagaat agaacagtga   3360

ttcttaaaat aagttagagc aggccgggcg cggtggctca tgcctgtaat cccagcactt   3420

tgggaggccg aggtgggtgg atcacgaggt caggagttca agaccagcct ggccaagatg   3480

atgaaacccc gtctctatta aaaatacaaa aattagctgg gcgtggtggc aggcacctgt   3540

aatcccagct tcctgggagg ctgaggcagg agaatcactt gaacccgggg ggcagaggtt   3600

gcagtgagcc gagatcacgc cactgaactc cagcctgggc aacagagtga gactctgtct   3660

caaaaaaaaa aaaaaaacaa aaacaaaaaa gcaagatcat ccactacaca tgaacatgaa   3720

tcacagtatt atttgcacag gaagggtgta acaaaatatg aatgtatcaa aaaatagaaa   3780

taaagtcttt gcagaaaaag tctgtttttc tctgaagtgt gttgagatta tctgacaact   3840

ctaagattgt acttaaattg tcaataaagc atc                                3873


<210>  3471
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  3471

Met Ile Val Phe Val Arg Phe Asn Ser Ser His Gly Phe Pro Val Glu 
1               5                   10                  15


Val Asp Ser Asp Thr Ser Ile Phe Gln Leu Lys Glu Val Val Ala Lys 
            20                  25                  30


Arg Gln Gly Val Pro Ala Asp Gln Leu Arg Val Ile Phe Ala Gly Lys 
        35                  40                  45


Glu Leu Arg Asn Asp Trp Thr Val Gln Glu Phe Phe Phe Lys Cys Gly 
    50                  55                  60


Ala His Pro Thr Ser Asp Lys Glu Thr Ser Val Ala Leu His Leu Ile 
65                  70                  75                  80


Ala Thr Asn Ser Arg Asn Ile Thr Cys Ile Thr Cys Thr Asp Val Arg 
                85                  90                  95


Ser Pro Val Leu Val Phe Gln Cys Asn Ser Arg His Val Ile Cys Leu 
            100                 105                 110


Asp Cys Phe His Leu Tyr Cys Val Thr Arg Leu Asn Asp Arg Gln Phe 
        115                 120                 125


Val His Asp Pro Gln Leu Gly Tyr Ser Leu Pro Cys Val Ala Gly Cys 
    130                 135                 140


Pro Asn Ser Leu Ile Lys Glu Leu His His Phe Arg Ile Leu Gly Glu 
145                 150                 155                 160


Glu Gln Tyr Asn Arg Tyr Gln Gln Tyr Gly Ala Glu Glu Cys Val Leu 
                165                 170                 175


Gln Met Gly Gly Val Leu Cys Pro Arg Pro Gly Cys Gly Ala Gly Leu 
            180                 185                 190


Leu Pro Glu Pro Asp Gln Arg Lys Val Thr Cys Glu Gly Gly Asn Gly 
        195                 200                 205


Leu Gly Cys Gly Phe Ala Phe Cys Arg Glu Cys Lys Glu Ala Tyr His 
    210                 215                 220


Glu Gly Glu Cys Ser Ala Val Phe Glu Ala Ser Gly Thr Thr Thr Gln 
225                 230                 235                 240


Ala Tyr Arg Val Asp Glu Arg Ala Ala Glu Gln Ala Arg Trp Glu Ala 
                245                 250                 255


Ala Ser Lys Glu Thr Ile Lys Lys Thr Thr Lys Pro Cys Pro Arg Cys 
            260                 265                 270


His Val Pro Val Glu Lys Asn Gly Gly Cys Met His Met Lys Cys Pro 
        275                 280                 285


Gln Pro Gln Cys Arg Leu Glu Trp Cys Trp Asn Cys Gly Cys Glu Trp 
    290                 295                 300


Asn Arg Val Cys Met Gly Asp His Trp Phe Asp Val 
305                 310                 315


<210>  3472
<211>  4320
<212>  DNA
<213>  Homo sapiens

<400>  3472
ctgaagccgg aaagggcggc ggtggggggc tgggggcagg aggcgtgagg agaaactacg     60

cgttagaact acgactccca gcaggccctg ggccgcgccc tccgcgcgtg cgcattccta    120

gggccgggcg cgggggcggg gaggcctgga ggatttaacc caggagagcc gctggtggga    180

ggcgcggctg gcgccgctgc gcgcatgggc ctgttcctgg cccgcagccg ccacctaccc    240

agtgaccatg atagtgtttg tcaggttcaa ctccagccat ggtttcccag tggaggtcga    300

ttctgacacc agcatcttcc agctcaagga ggtggttgct aagcgacagg gggttccggc    360

tgaccagttg cgtgtgattt tcgcagggaa ggagctgagg aatgactgga ctgtgcagaa    420

ttgtgacctg gatcagcaga gcattgttca cattgtgcag agaccgtgga gaaaaggtca    480

agaaatgaat gcaactggag gcgacgaccc cagaaacgcg gcgggaggct gtgagcggga    540

gccccagagc ttgactcggg tggacctcag cagctcagtc ctcccaggag actctgtggg    600

gctggctgtc attctgcaca ctgacagcag gaaggactca ccaccagctg gaagtccagc    660

aggtagatca atctacaaca gcttttatgt gtattgcaaa ggcccctgtc aaagagtgca    720

gccgggaaaa ctcagggtac agtgcagcac ctgcaggcag gcaacgctca ccttgaccca    780

gggtccatct tgctgggatg atgttttaat tccaaaccgg atgagtggtg aatgccaatc    840

cccacactgc cctgggacta gtgcagaatt tttctttaaa tgtggagcac accccacctc    900

tgacaaggaa acatcagtag ctttgcacct gatcgcaaca aatagtcgga acatcacttg    960

cattacgtgc acagacgtca ggagccccgt cctggttttc cagtgcaact cccgccacgt   1020

gatttgctta gactgtttcc acttatactg tgtgacaaga ctcaatgatc ggcagtttgt   1080

tcacgaccct caacttggct actccctgcc ttgtgtggct ggctgtccca actccttgat   1140

taaagagctc catcacttca ggattctggg agaagagcag tacaaccggt accagcagta   1200

tggtgcagag gagtgtgtcc tgcagatggg gggcgtgtta tgcccccgcc ctggctgtgg   1260

agcggggctg ctgccggagc ctgaccagag gaaagtcacc tgcgaagggg gcaatggcct   1320

gggctgtggg tttgccttct gccgggaatg taaagaagcg taccatgaag gggagtgcag   1380

tgccgtattt gaagcctcag gaacaactac tcaggcctac agagtcgatg aaagagccgc   1440

cgagcaggct cgttgggaag cagcctccaa agaaaccatc aagaaaacca ccaagccctg   1500

tccccgctgc catgtaccag tggaaaaaaa tggaggctgc atgcacatga agtgtccgca   1560

gccccagtgc aggctcgagt ggtgctggaa ctgtggctgc gagtggaacc gcgtctgcat   1620

gggggaccac tggttcgacg tgtagccagg gcggccgggc gccccatcgc cacatcctgg   1680

gggagcatac ccagtgtcta ccttcatttt ctaattctct tttcaaacac acacacacac   1740

gcgcgcgcgc gcacacacac tcttcaagtt tttttcaaag tccaactaca gccaaattgc   1800

agaagaaact cctggatccc tttcactatg tccatgaaaa acagcagagt aaaattacag   1860

aagaagctcc tgaatccctt tcagtttgtc cacacaagac agcagagcca tctgcgacac   1920

caccaacagg cgttctcagc ctccggatga cacaaatacc agagcacaga ttcaagtgca   1980

atccatgtat ctgtatgggt cattctcacc tgaattcgag acaggcagaa tcagtagctg   2040

gagagagagt tctcacattt aatatcctgc cttttacctt cagtaaacac catgaagatg   2100

ccattgacaa ggtgtttctc tgtaaaatga actgcagtgg gttctccaaa ctagattcat   2160

ggctttaaca gtaatgttct tatttaaatt ttcagaaagc atctattccc aaagaacccc   2220

aggcaatagt caaaaacatt tgtttatcct taagaattcc atctatataa atcgcattaa   2280

tgaaatacca actatgcgta aatcaacttg tcacaaagtg agaaattatg aaagttaatt   2340

tgaatgttga atgtttgaat tacagggaag aaatcaagtt aatgtacttt cattcccttt   2400

catgatttgc aactttagaa agaaattgtt tttctgaaag tatcaccaaa aaatctatag   2460

tttgattctg agtattcatt ttgcaacttg gagattttgc taatacattt ggctccactg   2520

taaatttaat agataaagtg cctataaagg aaacacgttt agaaatgatt tcaaaatgat   2580

attcaatctt aacaaaagtg aacattatta aatcagaatc tttaaagagg agcctttcca   2640

gaactaccaa aatgaagaca cgcccgactc tctccatcag aagggtttat acccctttgg   2700

cacaccctct ctgtccaatc tgcaagtccc agggagctct gcataccagg ggttccccag   2760

gagagacctt ctcttaggac agtaaactca ctagaatatt ccttatgttg acatggattg   2820

gatttcagtt caatcaaact ttcagctttt ttttcagcca ttcacaacac aatcaaaaga   2880

ttaacaacac tgcatgcggc aaaccgcatg ctcttaccca cactacgcag aagagaaagt   2940

acaaccacta tcttttgttc tacctgtatt gtctgacttc tcaggaagat cgtgaacata   3000

actgagggca tgagtctcac tagcacatgg aggccctttt ggatttagag actgtaaatt   3060

attaaatcgg caacagggct tctcttttta gatgtagcac tgaaatcctt gctggaggga   3120

agagagggga tgaactcaag ttttccacat cctgggacac ctgtccctct tttcctaact   3180

gcctaagata acccatttct tccaaccatc tgaggacagt cccgtcgtct cagaggccct   3240

gcaccgggga gagactgggc tctgcagcag ccacatcagc attcacagct tcatgtggct   3300

tcactgtctg aaaatctacc gactccaaca tggccccacg gtgacaacag acctgtgaca   3360

ggaagcccaa agctcacata gaaatggtgg acagatcaaa gtctctatag taagggaaaa   3420

aaagagaggt ggcaggcatg agccccctgc acccagtggc tcgtgtccat actgagtcca   3480

gaccctgatc aaggcctgac ttagtgtcac tggcagtccc actaaattac acttccttac   3540

actggcccga tgcgacaaat caggtggctc ccttctgtca cgtggagcac acagtgtttt   3600

ccatcatcca tagctttctt cctgatggtg tttgcattat tgcgccttcc caatctgcat   3660

gctgcgttgg gcttgcggtg cctgaacaag gtttgctccc atgagctcag gcaccctagg   3720

atcccctgtt agactattag gctgtccagc atggtctcct ttcccttctt ggtggtggtc   3780

ttttcccttt ccagaataga acagtgattc ttaaaataag ttagagcagg ccgggcgcgg   3840

tggctcatgc ctgtaatccc agcactttgg gaggccgagg tgggtggatc acgaggtcag   3900

gagttcaaga ccagcctggc caagatgatg aaaccccgtc tctattaaaa atacaaaaat   3960

tagctgggcg tggtggcagg cacctgtaat cccagcttcc tgggaggctg aggcaggaga   4020

atcacttgaa cccggggggc agaggttgca gtgagccgag atcacgccac tgaactccag   4080

cctgggcaac agagtgagac tctgtctcaa aaaaaaaaaa aaaacaaaaa caaaaaagca   4140

agatcatcca ctacacatga acatgaatca cagtattatt tgcacaggaa gggtgtaaca   4200

aaatatgaat gtatcaaaaa atagaaataa agtctttgca gaaaaagtct gtttttctct   4260

gaagtgtgtt gagattatct gacaactcta agattgtact taaattgtca ataaagcatc   4320


<210>  3473
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  3473

Met Ile Val Phe Val Arg Phe Asn Ser Ser His Gly Phe Pro Val Glu 
1               5                   10                  15


Val Asp Ser Asp Thr Ser Ile Phe Gln Leu Lys Glu Val Val Ala Lys 
            20                  25                  30


Arg Gln Gly Val Pro Ala Asp Gln Leu Arg Val Ile Phe Ala Gly Lys 
        35                  40                  45


Glu Leu Arg Asn Asp Trp Thr Val Gln Asn Cys Asp Leu Asp Gln Gln 
    50                  55                  60


Ser Ile Val His Ile Val Gln Arg Pro Trp Arg Lys Gly Gln Glu Met 
65                  70                  75                  80


Asn Ala Thr Gly Gly Asp Asp Pro Arg Asn Ala Ala Gly Gly Cys Glu 
                85                  90                  95


Arg Glu Pro Gln Ser Leu Thr Arg Val Asp Leu Ser Ser Ser Val Leu 
            100                 105                 110


Pro Gly Asp Ser Val Gly Leu Ala Val Ile Leu His Thr Asp Ser Arg 
        115                 120                 125


Lys Asp Ser Pro Pro Ala Gly Ser Pro Ala Gly Arg Ser Ile Tyr Asn 
    130                 135                 140


Ser Phe Tyr Val Tyr Cys Lys Gly Pro Cys Gln Arg Val Gln Pro Gly 
145                 150                 155                 160


Lys Leu Arg Val Gln Cys Ser Thr Cys Arg Gln Ala Thr Leu Thr Leu 
                165                 170                 175


Thr Gln Gly Pro Ser Cys Trp Asp Asp Val Leu Ile Pro Asn Arg Met 
            180                 185                 190


Ser Gly Glu Cys Gln Ser Pro His Cys Pro Gly Thr Ser Ala Glu Phe 
        195                 200                 205


Phe Phe Lys Cys Gly Ala His Pro Thr Ser Asp Lys Glu Thr Ser Val 
    210                 215                 220


Ala Leu His Leu Ile Ala Thr Asn Ser Arg Asn Ile Thr Cys Ile Thr 
225                 230                 235                 240


Cys Thr Asp Val Arg Ser Pro Val Leu Val Phe Gln Cys Asn Ser Arg 
                245                 250                 255


His Val Ile Cys Leu Asp Cys Phe His Leu Tyr Cys Val Thr Arg Leu 
            260                 265                 270


Asn Asp Arg Gln Phe Val His Asp Pro Gln Leu Gly Tyr Ser Leu Pro 
        275                 280                 285


Cys Val Ala Gly Cys Pro Asn Ser Leu Ile Lys Glu Leu His His Phe 
    290                 295                 300


Arg Ile Leu Gly Glu Glu Gln Tyr Asn Arg Tyr Gln Gln Tyr Gly Ala 
305                 310                 315                 320


Glu Glu Cys Val Leu Gln Met Gly Gly Val Leu Cys Pro Arg Pro Gly 
                325                 330                 335


Cys Gly Ala Gly Leu Leu Pro Glu Pro Asp Gln Arg Lys Val Thr Cys 
            340                 345                 350


Glu Gly Gly Asn Gly Leu Gly Cys Gly Phe Ala Phe Cys Arg Glu Cys 
        355                 360                 365


Lys Glu Ala Tyr His Glu Gly Glu Cys Ser Ala Val Phe Glu Ala Ser 
    370                 375                 380


Gly Thr Thr Thr Gln Ala Tyr Arg Val Asp Glu Arg Ala Ala Glu Gln 
385                 390                 395                 400


Ala Arg Trp Glu Ala Ala Ser Lys Glu Thr Ile Lys Lys Thr Thr Lys 
                405                 410                 415


Pro Cys Pro Arg Cys His Val Pro Val Glu Lys Asn Gly Gly Cys Met 
            420                 425                 430


His Met Lys Cys Pro Gln Pro Gln Cys Arg Leu Glu Trp Cys Trp Asn 
        435                 440                 445


Cys Gly Cys Glu Trp Asn Arg Val Cys Met Gly Asp His Trp Phe Asp 
    450                 455                 460


Val 
465


<210>  3474
<211>  4236
<212>  DNA
<213>  Homo sapiens

<400>  3474
ctgaagccgg aaagggcggc ggtggggggc tgggggcagg aggcgtgagg agaaactacg     60

cgttagaact acgactccca gcaggccctg ggccgcgccc tccgcgcgtg cgcattccta    120

gggccgggcg cgggggcggg gaggcctgga ggatttaacc caggagagcc gctggtggga    180

ggcgcggctg gcgccgctgc gcgcatgggc ctgttcctgg cccgcagccg ccacctaccc    240

agtgaccatg atagtgtttg tcaggttcaa ctccagccat ggtttcccag tggaggtcga    300

ttctgacacc agcatcttcc agctcaagga ggtggttgct aagcgacagg gggttccggc    360

tgaccagttg cgtgtgattt tcgcagggaa ggagctgagg aatgactgga ctgtgcagaa    420

ttgtgacctg gatcagcaga gcattgttca cattgtgcag agaccgtgga gaaaaggtca    480

agaaatgaat gcaactggag gcgacgaccc cagaaacgcg gcgggaggct gtgagcggga    540

gccccagagc ttgactcggg tggacctcag cagctcagtc ctcccaggag actctgtggg    600

gctggctgtc attctgcaca ctgacagcag gaaggactca ccaccagctg gaagtccagc    660

aggtagatca atctacaaca gcttttatgt gtattgcaaa ggcccctgtc aaagagtgca    720

gccgggaaaa ctcagggtac agtgcagcac ctgcaggcag gcaacgctca ccttgaccca    780

ggaatttttc tttaaatgtg gagcacaccc cacctctgac aaggaaacat cagtagcttt    840

gcacctgatc gcaacaaata gtcggaacat cacttgcatt acgtgcacag acgtcaggag    900

ccccgtcctg gttttccagt gcaactcccg ccacgtgatt tgcttagact gtttccactt    960

atactgtgtg acaagactca atgatcggca gtttgttcac gaccctcaac ttggctactc   1020

cctgccttgt gtggctggct gtcccaactc cttgattaaa gagctccatc acttcaggat   1080

tctgggagaa gagcagtaca accggtacca gcagtatggt gcagaggagt gtgtcctgca   1140

gatggggggc gtgttatgcc cccgccctgg ctgtggagcg gggctgctgc cggagcctga   1200

ccagaggaaa gtcacctgcg aagggggcaa tggcctgggc tgtgggtttg ccttctgccg   1260

ggaatgtaaa gaagcgtacc atgaagggga gtgcagtgcc gtatttgaag cctcaggaac   1320

aactactcag gcctacagag tcgatgaaag agccgccgag caggctcgtt gggaagcagc   1380

ctccaaagaa accatcaaga aaaccaccaa gccctgtccc cgctgccatg taccagtgga   1440

aaaaaatgga ggctgcatgc acatgaagtg tccgcagccc cagtgcaggc tcgagtggtg   1500

ctggaactgt ggctgcgagt ggaaccgcgt ctgcatgggg gaccactggt tcgacgtgta   1560

gccagggcgg ccgggcgccc catcgccaca tcctggggga gcatacccag tgtctacctt   1620

cattttctaa ttctcttttc aaacacacac acacacgcgc gcgcgcgcac acacactctt   1680

caagtttttt tcaaagtcca actacagcca aattgcagaa gaaactcctg gatccctttc   1740

actatgtcca tgaaaaacag cagagtaaaa ttacagaaga agctcctgaa tccctttcag   1800

tttgtccaca caagacagca gagccatctg cgacaccacc aacaggcgtt ctcagcctcc   1860

ggatgacaca aataccagag cacagattca agtgcaatcc atgtatctgt atgggtcatt   1920

ctcacctgaa ttcgagacag gcagaatcag tagctggaga gagagttctc acatttaata   1980

tcctgccttt taccttcagt aaacaccatg aagatgccat tgacaaggtg tttctctgta   2040

aaatgaactg cagtgggttc tccaaactag attcatggct ttaacagtaa tgttcttatt   2100

taaattttca gaaagcatct attcccaaag aaccccaggc aatagtcaaa aacatttgtt   2160

tatccttaag aattccatct atataaatcg cattaatgaa ataccaacta tgcgtaaatc   2220

aacttgtcac aaagtgagaa attatgaaag ttaatttgaa tgttgaatgt ttgaattaca   2280

gggaagaaat caagttaatg tactttcatt ccctttcatg atttgcaact ttagaaagaa   2340

attgtttttc tgaaagtatc accaaaaaat ctatagtttg attctgagta ttcattttgc   2400

aacttggaga ttttgctaat acatttggct ccactgtaaa tttaatagat aaagtgccta   2460

taaaggaaac acgtttagaa atgatttcaa aatgatattc aatcttaaca aaagtgaaca   2520

ttattaaatc agaatcttta aagaggagcc tttccagaac taccaaaatg aagacacgcc   2580

cgactctctc catcagaagg gtttataccc ctttggcaca ccctctctgt ccaatctgca   2640

agtcccaggg agctctgcat accaggggtt ccccaggaga gaccttctct taggacagta   2700

aactcactag aatattcctt atgttgacat ggattggatt tcagttcaat caaactttca   2760

gctttttttt cagccattca caacacaatc aaaagattaa caacactgca tgcggcaaac   2820

cgcatgctct tacccacact acgcagaaga gaaagtacaa ccactatctt ttgttctacc   2880

tgtattgtct gacttctcag gaagatcgtg aacataactg agggcatgag tctcactagc   2940

acatggaggc ccttttggat ttagagactg taaattatta aatcggcaac agggcttctc   3000

tttttagatg tagcactgaa atccttgctg gagggaagag aggggatgaa ctcaagtttt   3060

ccacatcctg ggacacctgt ccctcttttc ctaactgcct aagataaccc atttcttcca   3120

accatctgag gacagtcccg tcgtctcaga ggccctgcac cggggagaga ctgggctctg   3180

cagcagccac atcagcattc acagcttcat gtggcttcac tgtctgaaaa tctaccgact   3240

ccaacatggc cccacggtga caacagacct gtgacaggaa gcccaaagct cacatagaaa   3300

tggtggacag atcaaagtct ctatagtaag ggaaaaaaag agaggtggca ggcatgagcc   3360

ccctgcaccc agtggctcgt gtccatactg agtccagacc ctgatcaagg cctgacttag   3420

tgtcactggc agtcccacta aattacactt ccttacactg gcccgatgcg acaaatcagg   3480

tggctccctt ctgtcacgtg gagcacacag tgttttccat catccatagc tttcttcctg   3540

atggtgtttg cattattgcg ccttcccaat ctgcatgctg cgttgggctt gcggtgcctg   3600

aacaaggttt gctcccatga gctcaggcac cctaggatcc cctgttagac tattaggctg   3660

tccagcatgg tctcctttcc cttcttggtg gtggtctttt ccctttccag aatagaacag   3720

tgattcttaa aataagttag agcaggccgg gcgcggtggc tcatgcctgt aatcccagca   3780

ctttgggagg ccgaggtggg tggatcacga ggtcaggagt tcaagaccag cctggccaag   3840

atgatgaaac cccgtctcta ttaaaaatac aaaaattagc tgggcgtggt ggcaggcacc   3900

tgtaatccca gcttcctggg aggctgaggc aggagaatca cttgaacccg gggggcagag   3960

gttgcagtga gccgagatca cgccactgaa ctccagcctg ggcaacagag tgagactctg   4020

tctcaaaaaa aaaaaaaaaa caaaaacaaa aaagcaagat catccactac acatgaacat   4080

gaatcacagt attatttgca caggaagggt gtaacaaaat atgaatgtat caaaaaatag   4140

aaataaagtc tttgcagaaa aagtctgttt ttctctgaag tgtgttgaga ttatctgaca   4200

actctaagat tgtacttaaa ttgtcaataa agcatc                             4236


<210>  3475
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  3475

Met Ile Val Phe Val Arg Phe Asn Ser Ser His Gly Phe Pro Val Glu 
1               5                   10                  15


Val Asp Ser Asp Thr Ser Ile Phe Gln Leu Lys Glu Val Val Ala Lys 
            20                  25                  30


Arg Gln Gly Val Pro Ala Asp Gln Leu Arg Val Ile Phe Ala Gly Lys 
        35                  40                  45


Glu Leu Arg Asn Asp Trp Thr Val Gln Asn Cys Asp Leu Asp Gln Gln 
    50                  55                  60


Ser Ile Val His Ile Val Gln Arg Pro Trp Arg Lys Gly Gln Glu Met 
65                  70                  75                  80


Asn Ala Thr Gly Gly Asp Asp Pro Arg Asn Ala Ala Gly Gly Cys Glu 
                85                  90                  95


Arg Glu Pro Gln Ser Leu Thr Arg Val Asp Leu Ser Ser Ser Val Leu 
            100                 105                 110


Pro Gly Asp Ser Val Gly Leu Ala Val Ile Leu His Thr Asp Ser Arg 
        115                 120                 125


Lys Asp Ser Pro Pro Ala Gly Ser Pro Ala Gly Arg Ser Ile Tyr Asn 
    130                 135                 140


Ser Phe Tyr Val Tyr Cys Lys Gly Pro Cys Gln Arg Val Gln Pro Gly 
145                 150                 155                 160


Lys Leu Arg Val Gln Cys Ser Thr Cys Arg Gln Ala Thr Leu Thr Leu 
                165                 170                 175


Thr Gln Glu Phe Phe Phe Lys Cys Gly Ala His Pro Thr Ser Asp Lys 
            180                 185                 190


Glu Thr Ser Val Ala Leu His Leu Ile Ala Thr Asn Ser Arg Asn Ile 
        195                 200                 205


Thr Cys Ile Thr Cys Thr Asp Val Arg Ser Pro Val Leu Val Phe Gln 
    210                 215                 220


Cys Asn Ser Arg His Val Ile Cys Leu Asp Cys Phe His Leu Tyr Cys 
225                 230                 235                 240


Val Thr Arg Leu Asn Asp Arg Gln Phe Val His Asp Pro Gln Leu Gly 
                245                 250                 255


Tyr Ser Leu Pro Cys Val Ala Gly Cys Pro Asn Ser Leu Ile Lys Glu 
            260                 265                 270


Leu His His Phe Arg Ile Leu Gly Glu Glu Gln Tyr Asn Arg Tyr Gln 
        275                 280                 285


Gln Tyr Gly Ala Glu Glu Cys Val Leu Gln Met Gly Gly Val Leu Cys 
    290                 295                 300


Pro Arg Pro Gly Cys Gly Ala Gly Leu Leu Pro Glu Pro Asp Gln Arg 
305                 310                 315                 320


Lys Val Thr Cys Glu Gly Gly Asn Gly Leu Gly Cys Gly Phe Ala Phe 
                325                 330                 335


Cys Arg Glu Cys Lys Glu Ala Tyr His Glu Gly Glu Cys Ser Ala Val 
            340                 345                 350


Phe Glu Ala Ser Gly Thr Thr Thr Gln Ala Tyr Arg Val Asp Glu Arg 
        355                 360                 365


Ala Ala Glu Gln Ala Arg Trp Glu Ala Ala Ser Lys Glu Thr Ile Lys 
    370                 375                 380


Lys Thr Thr Lys Pro Cys Pro Arg Cys His Val Pro Val Glu Lys Asn 
385                 390                 395                 400


Gly Gly Cys Met His Met Lys Cys Pro Gln Pro Gln Cys Arg Leu Glu 
                405                 410                 415


Trp Cys Trp Asn Cys Gly Cys Glu Trp Asn Arg Val Cys Met Gly Asp 
            420                 425                 430


His Trp Phe Asp Val 
        435


<210>  3476
<211>  1713
<212>  DNA
<213>  Homo sapiens

<400>  3476
ctgaagccgg aaagggcggc ggtggggggc tgggggcagg aggcgtgagg agaaactacg     60

cgttagaact acgactccca gcaggccctg ggccgcgccc tccgcgcgtg cgcattccta    120

gggccgggcg cgggggcggg gaggcctgga ggatttaacc caggagagcc gctggtggga    180

ggcgcggctg gcgccgctgc gcgcatgggc ctgttcctgg cccgcagccg ccacctaccc    240

agtgaccatg atagtgtttg tcaggttcaa ctccagccat ggtttcccag tggaggtcga    300

ttctgacacc agcatcttcc agctcaagga ggtggttgct aagcgacagg gggttccggc    360

tgaccagttg cgtgtgattt tcgcagggaa ggagctgagg aatgactgga ctgtgcagaa    420

ttgtgacctg gatcagcaga gcattgttca cattgtgcag agaccgtgga gaaaaggtca    480

agaaatgaat gcaactggag gcgacgaccc cagaaacgcg gcgggaggct gtgagcggga    540

gccccagagc ttgactcggg tggacctcag cagctcagtc ctcccaggag actctgtggg    600

gctggctgtc attctgcaca ctgacagcag gaaggactca ccaccagctg gaagtccagc    660

aggtagatca atctacaaca gcttttatgt gtattgcaaa ggcccctgtc aaagagtgca    720

gccgggaaaa ctcagggtac agtgcagcac ctgcaggcag gcaacgctca ccttgaccca    780

gggtccatct tgctgggatg atgttttaat tccaaaccgg atgagtggtg aatgccaatc    840

cccacactgc cctgggacta gtgcagaatt tttctttaaa tgtggagcac accccacctc    900

tgacaaggaa acatcagtag ctttgcacct gatcgcaaca aatagtcgga acatcacttg    960

cattacgtgc acagacgtca ggagccccgt cctggttttc cagtgcaact cccgccacgt   1020

gatttgctta gactgtttcc acttatactg tgtgacaaga ctcaatgatc ggcagtttgt   1080

tcacgaccct caacttggct actccctgcc ttgtgtggga actggagaca cagtggtgct   1140

tagaggagct ctggggggat tcaggagagg agtcgctggc tgtcccaact ccttgattaa   1200

agagctccat cacttcagga ttctgggaga agagcagtac aaccggtacc agcagtatgg   1260

tgcagaggag tgtgtcctgc agatgggggg cgtgttatgc ccccgccctg gctgtggagc   1320

ggggctgctg ccggagcctg accagaggaa agtcacctgc gaagggggca atggcctggg   1380

ctgtgggtat ggacaacgaa gaacaaaata agctgcctca gggagaagtg agtgcctcat   1440

tcaatacatc gttcaaggaa aagtcattgg tagcaaagct atagaagaat tacagagttc   1500

cagatgtgga aaaagcccta gacgtcatta actccagtga ttatcaggat gtggttcaca   1560

gatttattgt aagatgcctg tgaattcacc cgtgcttaat ttttttttcc ctcaattatc   1620

aagatagaaa aagtacaact cttaccatgt gggtatgcaa gaaatgttag ctgttacaaa   1680

aaaaatcgcg tataaaaaag ttgaaaacca aat                                1713


<210>  3477
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  3477

Met Ile Val Phe Val Arg Phe Asn Ser Ser His Gly Phe Pro Val Glu 
1               5                   10                  15


Val Asp Ser Asp Thr Ser Ile Phe Gln Leu Lys Glu Val Val Ala Lys 
            20                  25                  30


Arg Gln Gly Val Pro Ala Asp Gln Leu Arg Val Ile Phe Ala Gly Lys 
        35                  40                  45


Glu Leu Arg Asn Asp Trp Thr Val Gln Asn Cys Asp Leu Asp Gln Gln 
    50                  55                  60


Ser Ile Val His Ile Val Gln Arg Pro Trp Arg Lys Gly Gln Glu Met 
65                  70                  75                  80


Asn Ala Thr Gly Gly Asp Asp Pro Arg Asn Ala Ala Gly Gly Cys Glu 
                85                  90                  95


Arg Glu Pro Gln Ser Leu Thr Arg Val Asp Leu Ser Ser Ser Val Leu 
            100                 105                 110


Pro Gly Asp Ser Val Gly Leu Ala Val Ile Leu His Thr Asp Ser Arg 
        115                 120                 125


Lys Asp Ser Pro Pro Ala Gly Ser Pro Ala Gly Arg Ser Ile Tyr Asn 
    130                 135                 140


Ser Phe Tyr Val Tyr Cys Lys Gly Pro Cys Gln Arg Val Gln Pro Gly 
145                 150                 155                 160


Lys Leu Arg Val Gln Cys Ser Thr Cys Arg Gln Ala Thr Leu Thr Leu 
                165                 170                 175


Thr Gln Gly Pro Ser Cys Trp Asp Asp Val Leu Ile Pro Asn Arg Met 
            180                 185                 190


Ser Gly Glu Cys Gln Ser Pro His Cys Pro Gly Thr Ser Ala Glu Phe 
        195                 200                 205


Phe Phe Lys Cys Gly Ala His Pro Thr Ser Asp Lys Glu Thr Ser Val 
    210                 215                 220


Ala Leu His Leu Ile Ala Thr Asn Ser Arg Asn Ile Thr Cys Ile Thr 
225                 230                 235                 240


Cys Thr Asp Val Arg Ser Pro Val Leu Val Phe Gln Cys Asn Ser Arg 
                245                 250                 255


His Val Ile Cys Leu Asp Cys Phe His Leu Tyr Cys Val Thr Arg Leu 
            260                 265                 270


Asn Asp Arg Gln Phe Val His Asp Pro Gln Leu Gly Tyr Ser Leu Pro 
        275                 280                 285


Cys Val Gly Thr Gly Asp Thr Val Val Leu Arg Gly Ala Leu Gly Gly 
    290                 295                 300


Phe Arg Arg Gly Val Ala Gly Cys Pro Asn Ser Leu Ile Lys Glu Leu 
305                 310                 315                 320


His His Phe Arg Ile Leu Gly Glu Glu Gln Tyr Asn Arg Tyr Gln Gln 
                325                 330                 335


Tyr Gly Ala Glu Glu Cys Val Leu Gln Met Gly Gly Val Leu Cys Pro 
            340                 345                 350


Arg Pro Gly Cys Gly Ala Gly Leu Leu Pro Glu Pro Asp Gln Arg Lys 
        355                 360                 365


Val Thr Cys Glu Gly Gly Asn Gly Leu Gly Cys Gly Tyr Gly Gln Arg 
    370                 375                 380


Arg Thr Lys 
385


<210>  3478
<211>  382
<212>  DNA
<213>  Homo sapiens

<400>  3478
ctgaagccgg aaagggcggc ggtggggggc tgggggcagg aggcgtgagg agaaactacg     60

cgttagaact acgactccca gcaggccctg ggccgcgccc tccgcgcgtg cgcattccta    120

gggccgggcg cgggggcggg gaggcctgga ggatttaacc caggagagcc gctggtggga    180

ggcgcggctg gcgccgctgc gcgcatgggc ctgttcctgg cccgcagccg ccacctaccc    240

agtgaccatg atagtccagc aggtagatca atctacaaca gcttttatgt gtattgcaaa    300

ggcccctgtc aaagagtgca gccgggaaaa ctcagggtac agtgcagcac ctgcaggcag    360

gcaacgctca ccttgaccca gg                                             382


<210>  3479
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  3479

Met Gly Leu Phe Leu Ala Arg Ser Arg His Leu Pro Ser Asp His Asp 
1               5                   10                  15


Ser Pro Ala Gly Arg Ser Ile Tyr Asn Ser Phe Tyr Val Tyr Cys Lys 
            20                  25                  30


Gly Pro Cys Gln Arg Val Gln Pro Gly Lys Leu Arg Val Gln Cys Ser 
        35                  40                  45


Thr Cys Arg Gln Ala Thr Leu Thr Leu Thr 
    50                  55


<210>  3480
<211>  647
<212>  DNA
<213>  Homo sapiens

<400>  3480
aacaaaacac tgaccttggt ccacagacaa cacccacgtc cacgtggtgg gtgggactgg     60

ctccgtcaga ggatgggaag atgagaagtg cttgtcgcag gcctggagat ggggaccacc    120

caggcatgca ggggatgctg cctctcctcc atccaacaac aagcctgcgt gtgcccagcc    180

ccctctggta cacgcattgc tccccatcct cggcattgat caattgaaaa taagaccttg    240

gaagaacccc ttgcaaagct gacattgtac gagccaaggc agtggccccg gagagggtca    300

gcgaggggcc tccactgtct gagtccgctc ctggcaacgc ctgctctctg cactcagagg    360

cccggtcccg gcagctgcca cgttgctcag aagttctggc agggggagcc tgaaacccct    420

gtctgctggc gacactcccg gagcagcagg aaatctctac attttatttt ttttcttaac    480

agacaaaagt atttgactcc agaatgattt ccaggaatta cagtatgaga acttagtctt    540

tgagattttt attttcttct taaaaaaata aaaatgaaat caaagcagaa gacactggtt    600

gagcagacag cacactagca cattccactt cgcaacaaaa cctgcgt                  647


<210>  3481
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  3481

Met Arg Ser Ala Cys Arg Arg Pro Gly Asp Gly Asp His Pro Gly Met 
1               5                   10                  15


Gln Gly Met Leu Pro Leu Leu His Pro Thr Thr Ser Leu Arg Val Pro 
            20                  25                  30


Ser Pro Leu Trp Tyr Thr His Cys Ser Pro Ser Ser Ala Leu Ile Asn 
        35                  40                  45


<210>  3482
<211>  568
<212>  DNA
<213>  Homo sapiens

<400>  3482
gtccacagac aacacccacg tccacgtggt gggtgggact ggctccgtca gaggatggga     60

agatgagaag tgcttgtcgc aggcctggag atggggacca cccaggcatg caggggatgc    120

tgcctctcct ccatccaaca acaagcctgc gtgtgcccag ccccctctgg tacacgcatt    180

gctccccatc ctcggcattg atcaattgaa aataagacct tggaagaacc ccttgcaaag    240

ctgacattgt acgagccaag gcagtggccc cggagagggt cagcgagggg cctccactgt    300

ctgagtccgc tcctggcaac gcctgctctc tgcactcaga ggcccggtcc cggcagctgc    360

cacgttgctc agaagttctg gcagggggag cctgaaaccc ctgtctgctg gcgacactcc    420

cggagcagca ggaaatctct acattttatt ttttttctta acagacaaaa gtatttgact    480

ccagaatgat ttccaggaat tacagtatga gaacttagtc tttgagattt ttattttctt    540

cttaaaaaaa taaaaatgaa atcaaagc                                       568


<210>  3483
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  3483

Met Arg Ser Ala Cys Arg Arg Pro Gly Asp Gly Asp His Pro Gly Met 
1               5                   10                  15


Gln Gly Met Leu Pro Leu Leu His Pro Thr Thr Ser Leu Arg Val Pro 
            20                  25                  30


Ser Pro Leu Trp Tyr Thr His Cys Ser Pro Ser Ser Ala Leu Ile Asn 
        35                  40                  45


<210>  3484
<211>  603
<212>  DNA
<213>  Homo sapiens

<400>  3484
cctggccgtg gggtcagctg cacaggccag gagctcgagg gtggtggctg gcagaaagtg     60

cagtccaaag tactctgttt tgttttgatt gtgttttaaa atgggacaaa taacagcatg    120

tgtgtttgct gatggggaga atccaggaga aaaacagtga agttgaggtg agcctcacag    180

ggtcaggggg aagacagggg atcccgaaga taacgtctgc tacgaactca attgcatccg    240

ccccgggccc taagttgaag ccctaatccc cacgttgact gcatttggag aaggaccttc    300

agcacatgat ggagggaccg agatgcccaa atcctggccc tcctgctgga ctttcatttt    360

aaagaacaat aaaattaatg ttaacttcta gcagcttcca agctctgtgg ccccggagag    420

ggtcagcgag gggcctccac tgtctgagtc cgctcctggc aacgcctgct ctctgcactc    480

agaggcccgg tcccggcagc tgccacgttg ctcagaagtt ctggcagggg gagcctgaaa    540

cccctgtctg ctggcgacac tcccggagca gcaggaaatc tctacatttt attttttttc    600

tta                                                                  603


<210>  3485
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  3485

Met Leu Thr Ser Ser Ser Phe Gln Ala Leu Trp Pro Arg Arg Gly Ser 
1               5                   10                  15


Ala Arg Gly Leu His Cys Leu Ser Pro Leu Leu Ala Thr Pro Ala Leu 
            20                  25                  30


Cys Thr Gln Arg Pro Gly Pro Gly Ser Cys His Val Ala Gln Lys Phe 
        35                  40                  45


Trp Gln Gly Glu Pro Glu Thr Pro Val Cys Trp Arg His Ser Arg Ser 
    50                  55                  60


Ser Arg Lys Ser Leu His Phe Ile Phe Phe 
65                  70


<210>  3486
<211>  544
<212>  DNA
<213>  Homo sapiens

<400>  3486
aagaagtgcc tttcacctct catcatgatt ctgtggcctc cccagccatg tggaactttt     60

ttctcttgct gctaccatgt aagaagtgcc tttcacctcg tgccatgatt atgagacttc    120

cccagccatg tggaactgtt aagtccaatt aaacatcttt ttcttcttag tcccaggttg    180

ttctcattcg tggctggatc acaccagcaa gaaggatttt aaaggacaac tccttggggc    240

cgtccaacac tgaaaccgcc tgaccgctgc tgtctttgtg cttgcagaaa atcacggtgg    300

gcacaaaatt ttggacacga tttcgagagc gtgagagcta ctgttcacga atccagggcc    360

agcctcgtgt ctgtcttcct ttaaagcacc tggcttggta cctaaaatgt tccttttttt    420

tttttttttg aaattcaata acttcagaac aggcgttgat gtagacagat ctccatcttt    480

ttggtttttt gagtgagttt ttgctctgta ggctgaattc tttggaattt agttctgaaa    540

tcac                                                                 544


<210>  3487
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  3487

Met Trp Asn Phe Phe Leu Leu Leu Leu Pro Cys Lys Lys Cys Leu Ser 
1               5                   10                  15


Pro Arg Ala Met Ile Met Arg Leu Pro Gln Pro Cys Gly Thr Val Lys 
            20                  25                  30


Ser Asn 



<210>  3488
<211>  683
<212>  DNA
<213>  Homo sapiens

<400>  3488
gtctagggta tatttttatc agcaacatga aaacagacta atacagtaaa ttggaaccag     60

cagagtgggg cgttgctgaa aagatactcg aaaatgtggc aactcaacac tctttatcaa    120

gagcaatctg tgaattttga agaaagaaca gacatcagaa aaaggaaatc tccatctaaa    180

gataaattca cctaaaattg cctagaacat gatgaaaact catgctttgc tccctggcta    240

taagcatttc tcttggggtg gttgcacatt ttactttctg gcttcccacc gctaggatgc    300

atgccacact gaacttaaat tccgtgacta actgccatgc acagatgtcc tggagacgaa    360

tacacaccag aaaatatgcc aagtatcaaa ttcacacaaa acattataga actagcaaat    420

atttgctgct tttggctgtg ttggaaatta tcttctgtga gataaatctt ttggctaaaa    480

tatgattttt aaagattctc aaatgttcga gtcttcattt ctgcattaat taaattaaga    540

tggagccagc gtctctgaga aagctcacaa gctcttaact cacgaggttg ctccgaagta    600

tctcactctg tttttactca tcctcctgcg tggcaaggaa gagaaagagc caataaataa    660

atgaaataaa cgaacagtcc ttc                                            683


<210>  3489
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  3489

Met Trp Gln Leu Asn Thr Leu Tyr Gln Glu Gln Ser Val Asn Phe Glu 
1               5                   10                  15


Glu Arg Thr Asp Ile Arg Lys Arg Lys Ser Pro Ser Lys Asp Lys Phe 
            20                  25                  30


Thr 



<210>  3490
<211>  1018
<212>  DNA
<213>  Homo sapiens

<400>  3490
gggacgcccc gacccaagcc ctgcagtccg cgcgcgtcag gggtgtgcgc tggaggccgg     60

aaagtcgaat atcacttccc atcctgcatt tgatgtgctt tggggttgaa aaagccctta    120

tgtggtaaaa aaaaaaaaaa aaaaaaagtc agaaaagtgg caaaagtctt caacggcctg    180

aaaaaggccg agacaggaac tgagaagctg gcagtaggtc ctgctactgc tgcaggggcg    240

gcgggcgccc tgggtgggcc acgaggcagg gacagccgag gctccgcgct caccccaccc    300

gcaaggggcc aagcgcagac tcaggggagc cagaggggcc ggaccgctga gcaagggctg    360

gggaaggatc ccacgcttgg atacttggga gtgaagatgt gttatttcac ccaccgactc    420

gttccacacg accaaggcct gtgcctgccc tgagggcgag ttggttgagc cttgtacaga    480

caactctcag agcgtgggcc tgggccgaac ctttccctgt gagcagcagc atcagcgtct    540

agaacgacgg ccctcccggt ccacggtgga aggtgcggag ctcccgtggt gtgctggcag    600

cgattcgcag aagggagatg gagggccaca gggcaggtgc tcgcacggag tcatcgaggt    660

ccagggacac cttcctccca ggagtgtgtg tacagtgatc acttgctgcc ataacacagt    720

cacagatcta cgtgtgttct ctgactctca gctggggctc catcggggcc tgctctgggc    780

tcacctgcgt gaccactggg ctcagcttcc tcgtctgaga agcatcagga ctggccttcc    840

cacccccgcg ttcccagggc ttccacactc ctttctagcc atgagtcagt cctcagtgga    900

tgaccagtgg cctggggtgg ccctctgatt ctctcacctg tactcagggg gctgaacctc    960

actcttctct gccaaaacca accaatgaat aaataaacaa acaagcatgg aattccta     1018


<210>  3491
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  3491

Met Thr Ser Gly Leu Gly Trp Pro Ser Asp Ser Leu Thr Cys Thr Gln 
1               5                   10                  15


Gly Ala Glu Pro His Ser Ser Leu Pro Lys Pro Thr Asn Glu 
            20                  25                  30


<210>  3492
<211>  860
<212>  DNA
<213>  Homo sapiens

<400>  3492
catatagaat aatgaggagt ttatgatgga accttaaata tataatgttg ccagcgattt     60

tagttcaata tttgttactg ttatctatct gctgtatatg gaattctttt aattcaaacg    120

ctgaaaagaa tcagcattta gtcttgccag gcacacccaa taatcagtca tgtgtaatat    180

gcacaagttt gtttttgttt ttgttttttt tgttggttgg tttgtttttt tgctttaagt    240

tgcatgatct ttctgcagga aatagtcact catcccactc cacataaggg gtttagtaag    300

agaagtctgt ctgtctgatg atggataggg ggcaaatctt tttccccttt ctgttaatag    360

tcatcacatt tctatgccaa acaggaacaa tccataactt tagtcttaat gtacacattg    420

cattttgata aaattaattt tgttgtttcc tttgaggttg atcgttgtgt tgttgttttg    480

ctgcactttt tacttttttg cgtgtggagc tgtattcccg agaccaacga agcgttggga    540

tacttcatta aatgtagcga ctgtcaacag cgtgcaggtt ttctgtttct gtgttgtggg    600

gtcaaccgta caatggtgtg ggagtgacga tgatgtgagt atttagaatg taccatattt    660

tttgtaaatt atttatgttt ttctaaacaa atttatcgta taggttgatg aaacgtcatg    720

tgttttgcca aagactgtaa atatttattt atgtgttcac atggtcaaaa tttcaccact    780

gaaaccctgc acttagctag aacctcattt ttaaagatta acaacaggaa ataaattgta    840

aaaaaggttt tctatacatg                                                860


<210>  3493
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  3493

Met Leu Pro Ala Ile Leu Val Gln Tyr Leu Leu Leu Leu Ser Ile Cys 
1               5                   10                  15


Cys Ile Trp Asn Ser Phe Asn Ser Asn Ala Glu Lys Asn Gln His Leu 
            20                  25                  30


Val Leu Pro Gly Thr Pro Asn Asn Gln Ser Cys Val Ile Cys Thr Ser 
        35                  40                  45


Leu Phe Leu Phe Leu Phe Phe Leu Leu Val Gly Leu Phe Phe Cys Phe 
    50                  55                  60


Lys Leu His Asp Leu Ser Ala Gly Asn Ser His Ser Ser His Ser Thr 
65                  70                  75                  80


<210>  3494
<211>  1368
<212>  DNA
<213>  Homo sapiens

<400>  3494
aatactgtgc ataagccatt atgataaatt aagcatgaaa aatattgctg aactactttt     60

ggtgcttaaa gttgtcacta ttcttgaatt agagttgctc tacaatgaca cacaaatccc    120

attaaataaa ttataaacaa gggtcaattc aaatttgaag taatgtttta gtaaggagag    180

attagaagac aacaggcata gcaaatgaca taagctaccg attaactaat cggaacatgt    240

aaaacagtta caaaaataaa cgaactctcc tcttgtccta caatgaaagc cctcatgtgc    300

agtagagatg cagtttcatc aaagaacaaa catccttgca aatgggtgtg acgcggttcc    360

agatgtggat ttggcaaaac ctcatttaag taaaaggtta gcagagcaaa gtgcggtgct    420

ttagctgctg cttgtgccgc tgtggcgtcg gggaggctcc tgcctgagct tccttcccca    480

gctttgctgc ctgagaggaa ccagagcaga cgcacaggcc ggaaaaggcg catctaacgc    540

gtatctaggc tttggtaact gcggacaagt tgcttttacc tgatttgatg atacatttca    600

ttaaggttcc agttataaat attttgttaa tatttattaa gtgactatag aatgcaactc    660

catttaccag taacttattt taaatatgcc tagtaacaca tatgtagtat aatttctaga    720

aacaaacatc taataagtat ataatcctgt gaaaatatga ggcttgataa tattaggttg    780

tcacgatgaa gcatgctaga agctgtaaca gaatacatag agaataatga ggagtttatg    840

atggaacctt aaatatataa tgttgccagc gattttagtt caatatttgt tactgttatc    900

tatctgctgt atatggaatt cttttaattc aaacgctgaa aagaatcagc atttagtctt    960

gccaggcaca cccaataatc agtcatgtgt aatatgcaca agtttgtttt tgtttttgtt   1020

ttttttgttg gttggtttgt ttttttgctt taagttgcat gatctttctg caggaaatag   1080

tcactcatcc cactccacat aaggggttta gtaagagaag tctgtctgtc tgatgatgga   1140

tagggggcaa atctttttcc cctttctgtt aatagtcatc acatttctat gccaaacagg   1200

aacaatccat aactttagtc ttaatgtaca cattgcattt tgataaaatt aattttgttg   1260

tttcctttga ggttgatcgt tgtgttgttg ttttgctgca ttagctagaa cctcattttt   1320

aaagattaac aacaggaaat aaattgtaaa aaaggttttc tatacatg                1368


<210>  3495
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  3495

Met Leu Pro Ala Ile Leu Val Gln Tyr Leu Leu Leu Leu Ser Ile Cys 
1               5                   10                  15


Cys Ile Trp Asn Ser Phe Asn Ser Asn Ala Glu Lys Asn Gln His Leu 
            20                  25                  30


Val Leu Pro Gly Thr Pro Asn Asn Gln Ser Cys Val Ile Cys Thr Ser 
        35                  40                  45


Leu Phe Leu Phe Leu Phe Phe Leu Leu Val Gly Leu Phe Phe Cys Phe 
    50                  55                  60


Lys Leu His Asp Leu Ser Ala Gly Asn Ser His Ser Ser His Ser Thr 
65                  70                  75                  80


<210>  3496
<211>  5880
<212>  DNA
<213>  Homo sapiens

<400>  3496
aaaagtgagt ccctgccttc cctctctccg tctggctcct cccaggcctg tctggcaggg     60

gccggggtgc aggaggagga gacggcatcc agtacagagg ggctggactt ggacccctgc    120

agcagccctg cacaggagaa gcggcatata aagccgcgct gcccgggagc cgctcggcca    180

cgtccaccgg agcatcctgc actgcagggc cggtctctcg ctccagcaga gcctgcgcct    240

ttctgactcg gtccggaaca ctgaaaccag tcatcactgc atctttttgg caaaccagga    300

gctcagctgc aggaggcagg atggtctgga ggctggtcct gctggctctg tgggtgtggc    360

ccagcacgca agctggtcac caggacaaag acacgacctt cgaccttttc agtatcagca    420

acatcaaccg caagaccatt ggcgccaagc agttccgcgg gcccgacccc ggcgtgccgg    480

cttaccgctt cgtgcgcttt gactacatcc caccggtgaa cgcagatgac ctcagcaaga    540

tcaccaagat catgcggcag aaggagggct tcttcctcac ggcccagctc aagcaggacg    600

gcaagtccag gggcacgctg ttggctctgg agggccccgg tctctcccag aggcagttcg    660

agatcgtctc caacggcccc gcggacacgc tggatctcac ctactggatt gacggcaccc    720

ggcatgtggt ctccctggag gacgtcggcc tggctgactc gcagtggaag aacgtcaccg    780

tgcaggtggc tggcgagacc tacagcttgc acgtgggctg cgacctcata gacagcttcg    840

ctctggacga gcccttctac gagcacctgc aggcggaaaa gagccggatg tacgtggcca    900

aaggctctgc cagagagagt cacttcaggg gtttgcttca gaacgtccac ctagtgtttg    960

aaaactctgt ggaagatatt ctaagcaaga agggttgcca gcaaggccag ggagctgaga   1020

tcaacgccat cagtgagaac acagagacgc tgcgcctggg tccgcatgtc accaccgagt   1080

acgtgggccc cagctcggag aggaggcccg aggtgtgcga acgctcgtgc gaggagctgg   1140

gaaacatggt ccaggagctc tcggggctcc acgtcctcgt gaaccagctc agcgagaacc   1200

tcaagagagt gtcgaatgat aaccagtttc tctgggagct cattggtggc cctcctaaga   1260

caaggaacat gtcagcttgc tggcaggatg gccggttctt tgcggaaaat gaaacgtggg   1320

tggtggacag ctgcaccacg tgtacctgca agaaatttaa aaccatttgc caccaaatca   1380

cctgcccgcc tgcaacctgc gccagtccat cctttgtgga aggcgaatgc tgcccttcct   1440

gcctccactc ggtggacggt gaggagggct ggtctccgtg ggcagagtgg acccagtgct   1500

ccgtgacgtg tggctctggg acccagcaga gaggccggtc ctgtgacgtc accagcaaca   1560

cctgcttggg gccctccatc cagacacggg cttgcagtct gagcaagtgt gacacccgca   1620

tccggcagga cggcggctgg agccactggt caccttggtc ttcatgctct gtgacctgtg   1680

gagttggcaa tatcacacgc atccgtctct gcaactcccc agtgccccag atggggggca   1740

agaattgcaa agggagtggc cgggagacca aagcctgcca gggcgcccca tgcccaatcg   1800

atggccgctg gagcccctgg tccccgtggt cggcctgcac tgtcacctgt gccggtggga   1860

tccgggagcg cacccgggtc tgcaacagcc ctgagcctca gtacggaggg aaggcctgcg   1920

tgggggatgt gcaggagcgt cagatgtgca acaagaggag ctgccccgtg gatggctgtt   1980

tatccaaccc ctgcttcccg ggagcccagt gcagcagctt ccccgatggg tcctggtcat   2040

gcggctcctg ccctgtgggc ttcttgggca atggcaccca ctgtgaggac ctggacgagt   2100

gtgccctggt ccccgacatc tgcttctcca ccagcaaggt gcctcgctgt gtcaacactc   2160

agcctggctt ccactgcctg ccctgcccgc cccgatacag agggaaccag cccgtcgggg   2220

tcggcctgga agcagccaag acggaaaagc aagtgtgtga gcccgaaaac ccatgcaagg   2280

acaagacaca caactgccac aagcacgcgg agtgcatcta cctgggccac ttcagcgacc   2340

ccatgtacaa gtgcgagtgc cagacaggct acgcgggcga cgggctcatc tgcggggagg   2400

actcggacct ggacggctgg cccaacctca atctggtctg cgccaccaac gccacctacc   2460

actgcatcaa ggataactgc ccccatctgc caaattctgg gcaggaagac tttgacaagg   2520

acgggattgg cgatgcctgt gatgatgacg atgacaatga cggtgtgacc gatgagaagg   2580

acaactgcca gctcctcttc aatccccgcc aggctgacta tgacaaggat gaggttgggg   2640

accgctgtga caactgccct tacgtgcaca accctgccca gatcgacaca gacaacaatg   2700

gagagggtga cgcctgctcc gtggacattg atggggacga tgtcttcaat gaacgagaca   2760

attgtcccta cgtctacaac actgaccaga gggacacgga tggtgacggt gtgggggatc   2820

actgtgacaa ctgccccctg gtgcacaacc ctgaccagac cgacgtggac aatgaccttg   2880

ttggggacca gtgtgacaac aacgaggaca tagatgacga cggccaccag aacaaccagg   2940

acaactgccc ctacatctcc aacgccaacc aggctgacca tgacagagac ggccagggcg   3000

acgcctgtga ccctgatgat gacaacgatg gcgtccccga tgacagggac aactgccggc   3060

ttgtgttcaa cccagaccag gaggacttgg acggtgatgg acggggtgat atttgtaaag   3120

atgattttga caatgacaac atcccagata ttgatgatgt gtgtcctgaa aacaatgcca   3180

tcagtgagac agacttcagg aacttccaga tggtcccctt ggatcccaaa gggaccaccc   3240

aaattgatcc caactgggtc attcgccatc aaggcaagga gctggttcag acagccaact   3300

cggaccccgg catcgctgta ggttttgacg agtttgggtc tgtggacttc agtggcacat   3360

tctacgtaaa cactgaccgg gacgacgact atgccggctt cgtctttggt taccagtcaa   3420

gcagccgctt ctatgtggtg atgtggaagc aggtgacgca gacctactgg gaggaccagc   3480

ccacgcgggc ctatggctac tccggcgtgt ccctcaaggt ggtgaactcc accacgggga   3540

cgggcgagca cctgaggaac gcgctgtggc acacggggaa cacgccgggg caggtgcgaa   3600

ccttatggca cgaccccagg aacattggct ggaaggacta cacggcctat aggtggcacc   3660

tgactcacag gcccaagact ggctacatca gagtcttagt gcatgaagga aaacaggtca   3720

tggcagactc aggacctatc tatgaccaaa cctacgctgg cgggcggctg ggtctatttg   3780

tcttctctca agaaatggtc tatttctcag acctcaagta cgaatgcaga gatatttaaa   3840

caagatttgc tgcatttccg gcaatgccct gtgcatgcca tggtccctag acacctcagt   3900

tcattgtggt ccttgtggct tctctctcta gcagcacctc ctgtcccttg accttaactc   3960

tgatggttct tcacctcctg ccagcaaccc caaacccaag tgccttcaga ggataaatat   4020

caatggaact cagagatgaa catctaaccc actagaggaa accagtttgg tgatatatga   4080

gactttatgt ggagtgaaaa ttgggcatgc cattacattg ctttttcttg tttgtttaaa   4140

aagaatgacg tttacatata aaatgtaatt acttattgta tttatgtgta tatggagttg   4200

aagggaatac tgtgcataag ccattatgat aaattaagca tgaaaaatat tgctgaacta   4260

cttttggtgc ttaaagttgt cactattctt gaattagagt tgctctacaa tgacacacaa   4320

atcccattaa ataaattata aacaagggtc aattcaaatt tgaagtaatg ttttagtaag   4380

gagagattag aagacaacag gcatagcaaa tgacataagc taccgattaa ctaatcggaa   4440

catgtaaaac agttacaaaa ataaacgaac tctcctcttg tcctacaatg aaagccctca   4500

tgtgcagtag agatgcagtt tcatcaaaga acaaacatcc ttgcaaatgg gtgtgacgcg   4560

gttccagatg tggatttggc aaaacctcat ttaagtaaaa ggttagcaga gcaaagtgcg   4620

gtgctttagc tgctgcttgt gccgctgtgg cgtcggggag gctcctgcct gagcttcctt   4680

ccccagcttt gctgcctgag aggaaccaga gcagacgcac aggccggaaa aggcgcatct   4740

aacgcgtatc taggctttgg taactgcgga caagttgctt ttacctgatt tgatgataca   4800

tttcattaag gttccagtta taaatatttt gttaatattt attaagtgac tatagaatgc   4860

aactccattt accagtaact tattttaaat atgcctagta acacatatgt agtataattt   4920

ctagaaacaa acatctaata agtatataat cctgtgaaaa tatgaggctt gataatatta   4980

ggttgtcacg atgaagcatg ctagaagctg taacagaata catagagaat aatgaggagt   5040

ttatgatgga accttaaata tataatgttg ccagcgattt tagttcaata tttgttactg   5100

ttatctatct gctgtatatg gaattctttt aattcaaacg ctgaaaagaa tcagcattta   5160

gtcttgccag gcacacccaa taatcagtca tgtgtaatat gcacaagttt gtttttgttt   5220

ttgttttttt tgttggttgg tttgtttttt tgctttaagt tgcatgatct ttctgcagga   5280

aatagtcact catcccactc cacataaggg gtttagtaag agaagtctgt ctgtctgatg   5340

atggataggg ggcaaatctt tttccccttt ctgttaatag tcatcacatt tctatgccaa   5400

acaggaacaa tccataactt tagtcttaat gtacacattg cattttgata aaattaattt   5460

tgttgtttcc tttgaggttg atcgttgtgt tgttgttttg ctgcactttt tacttttttg   5520

cgtgtggagc tgtattcccg agaccaacga agcgttggga tacttcatta aatgtagcga   5580

ctgtcaacag cgtgcaggtt ttctgtttct gtgttgtggg gtcaaccgta caatggtgtg   5640

ggagtgacga tgatgtgagt atttagaatg taccatattt tttgtaaatt atttatgttt   5700

ttctaaacaa atttatcgta taggttgatg aaacgtcatg tgttttgcca aagactgtaa   5760

atatttattt atgtgttcac atggtcaaaa tttcaccact gaaaccctgc acttagctag   5820

aacctcattt ttaaagatta acaacaggaa ataaattgta aaaaaggttt tctatacatg   5880


<210>  3497
<211>  1172
<212>  PRT
<213>  Homo sapiens

<400>  3497

Met Val Trp Arg Leu Val Leu Leu Ala Leu Trp Val Trp Pro Ser Thr 
1               5                   10                  15


Gln Ala Gly His Gln Asp Lys Asp Thr Thr Phe Asp Leu Phe Ser Ile 
            20                  25                  30


Ser Asn Ile Asn Arg Lys Thr Ile Gly Ala Lys Gln Phe Arg Gly Pro 
        35                  40                  45


Asp Pro Gly Val Pro Ala Tyr Arg Phe Val Arg Phe Asp Tyr Ile Pro 
    50                  55                  60


Pro Val Asn Ala Asp Asp Leu Ser Lys Ile Thr Lys Ile Met Arg Gln 
65                  70                  75                  80


Lys Glu Gly Phe Phe Leu Thr Ala Gln Leu Lys Gln Asp Gly Lys Ser 
                85                  90                  95


Arg Gly Thr Leu Leu Ala Leu Glu Gly Pro Gly Leu Ser Gln Arg Gln 
            100                 105                 110


Phe Glu Ile Val Ser Asn Gly Pro Ala Asp Thr Leu Asp Leu Thr Tyr 
        115                 120                 125


Trp Ile Asp Gly Thr Arg His Val Val Ser Leu Glu Asp Val Gly Leu 
    130                 135                 140


Ala Asp Ser Gln Trp Lys Asn Val Thr Val Gln Val Ala Gly Glu Thr 
145                 150                 155                 160


Tyr Ser Leu His Val Gly Cys Asp Leu Ile Asp Ser Phe Ala Leu Asp 
                165                 170                 175


Glu Pro Phe Tyr Glu His Leu Gln Ala Glu Lys Ser Arg Met Tyr Val 
            180                 185                 190


Ala Lys Gly Ser Ala Arg Glu Ser His Phe Arg Gly Leu Leu Gln Asn 
        195                 200                 205


Val His Leu Val Phe Glu Asn Ser Val Glu Asp Ile Leu Ser Lys Lys 
    210                 215                 220


Gly Cys Gln Gln Gly Gln Gly Ala Glu Ile Asn Ala Ile Ser Glu Asn 
225                 230                 235                 240


Thr Glu Thr Leu Arg Leu Gly Pro His Val Thr Thr Glu Tyr Val Gly 
                245                 250                 255


Pro Ser Ser Glu Arg Arg Pro Glu Val Cys Glu Arg Ser Cys Glu Glu 
            260                 265                 270


Leu Gly Asn Met Val Gln Glu Leu Ser Gly Leu His Val Leu Val Asn 
        275                 280                 285


Gln Leu Ser Glu Asn Leu Lys Arg Val Ser Asn Asp Asn Gln Phe Leu 
    290                 295                 300


Trp Glu Leu Ile Gly Gly Pro Pro Lys Thr Arg Asn Met Ser Ala Cys 
305                 310                 315                 320


Trp Gln Asp Gly Arg Phe Phe Ala Glu Asn Glu Thr Trp Val Val Asp 
                325                 330                 335


Ser Cys Thr Thr Cys Thr Cys Lys Lys Phe Lys Thr Ile Cys His Gln 
            340                 345                 350


Ile Thr Cys Pro Pro Ala Thr Cys Ala Ser Pro Ser Phe Val Glu Gly 
        355                 360                 365


Glu Cys Cys Pro Ser Cys Leu His Ser Val Asp Gly Glu Glu Gly Trp 
    370                 375                 380


Ser Pro Trp Ala Glu Trp Thr Gln Cys Ser Val Thr Cys Gly Ser Gly 
385                 390                 395                 400


Thr Gln Gln Arg Gly Arg Ser Cys Asp Val Thr Ser Asn Thr Cys Leu 
                405                 410                 415


Gly Pro Ser Ile Gln Thr Arg Ala Cys Ser Leu Ser Lys Cys Asp Thr 
            420                 425                 430


Arg Ile Arg Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser 
        435                 440                 445


Cys Ser Val Thr Cys Gly Val Gly Asn Ile Thr Arg Ile Arg Leu Cys 
    450                 455                 460


Asn Ser Pro Val Pro Gln Met Gly Gly Lys Asn Cys Lys Gly Ser Gly 
465                 470                 475                 480


Arg Glu Thr Lys Ala Cys Gln Gly Ala Pro Cys Pro Ile Asp Gly Arg 
                485                 490                 495


Trp Ser Pro Trp Ser Pro Trp Ser Ala Cys Thr Val Thr Cys Ala Gly 
            500                 505                 510


Gly Ile Arg Glu Arg Thr Arg Val Cys Asn Ser Pro Glu Pro Gln Tyr 
        515                 520                 525


Gly Gly Lys Ala Cys Val Gly Asp Val Gln Glu Arg Gln Met Cys Asn 
    530                 535                 540


Lys Arg Ser Cys Pro Val Asp Gly Cys Leu Ser Asn Pro Cys Phe Pro 
545                 550                 555                 560


Gly Ala Gln Cys Ser Ser Phe Pro Asp Gly Ser Trp Ser Cys Gly Ser 
                565                 570                 575


Cys Pro Val Gly Phe Leu Gly Asn Gly Thr His Cys Glu Asp Leu Asp 
            580                 585                 590


Glu Cys Ala Leu Val Pro Asp Ile Cys Phe Ser Thr Ser Lys Val Pro 
        595                 600                 605


Arg Cys Val Asn Thr Gln Pro Gly Phe His Cys Leu Pro Cys Pro Pro 
    610                 615                 620


Arg Tyr Arg Gly Asn Gln Pro Val Gly Val Gly Leu Glu Ala Ala Lys 
625                 630                 635                 640


Thr Glu Lys Gln Val Cys Glu Pro Glu Asn Pro Cys Lys Asp Lys Thr 
                645                 650                 655


His Asn Cys His Lys His Ala Glu Cys Ile Tyr Leu Gly His Phe Ser 
            660                 665                 670


Asp Pro Met Tyr Lys Cys Glu Cys Gln Thr Gly Tyr Ala Gly Asp Gly 
        675                 680                 685


Leu Ile Cys Gly Glu Asp Ser Asp Leu Asp Gly Trp Pro Asn Leu Asn 
    690                 695                 700


Leu Val Cys Ala Thr Asn Ala Thr Tyr His Cys Ile Lys Asp Asn Cys 
705                 710                 715                 720


Pro His Leu Pro Asn Ser Gly Gln Glu Asp Phe Asp Lys Asp Gly Ile 
                725                 730                 735


Gly Asp Ala Cys Asp Asp Asp Asp Asp Asn Asp Gly Val Thr Asp Glu 
            740                 745                 750


Lys Asp Asn Cys Gln Leu Leu Phe Asn Pro Arg Gln Ala Asp Tyr Asp 
        755                 760                 765


Lys Asp Glu Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Val His Asn 
    770                 775                 780


Pro Ala Gln Ile Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ser 
785                 790                 795                 800


Val Asp Ile Asp Gly Asp Asp Val Phe Asn Glu Arg Asp Asn Cys Pro 
                805                 810                 815


Tyr Val Tyr Asn Thr Asp Gln Arg Asp Thr Asp Gly Asp Gly Val Gly 
            820                 825                 830


Asp His Cys Asp Asn Cys Pro Leu Val His Asn Pro Asp Gln Thr Asp 
        835                 840                 845


Val Asp Asn Asp Leu Val Gly Asp Gln Cys Asp Asn Asn Glu Asp Ile 
    850                 855                 860


Asp Asp Asp Gly His Gln Asn Asn Gln Asp Asn Cys Pro Tyr Ile Ser 
865                 870                 875                 880


Asn Ala Asn Gln Ala Asp His Asp Arg Asp Gly Gln Gly Asp Ala Cys 
                885                 890                 895


Asp Pro Asp Asp Asp Asn Asp Gly Val Pro Asp Asp Arg Asp Asn Cys 
            900                 905                 910


Arg Leu Val Phe Asn Pro Asp Gln Glu Asp Leu Asp Gly Asp Gly Arg 
        915                 920                 925


Gly Asp Ile Cys Lys Asp Asp Phe Asp Asn Asp Asn Ile Pro Asp Ile 
    930                 935                 940


Asp Asp Val Cys Pro Glu Asn Asn Ala Ile Ser Glu Thr Asp Phe Arg 
945                 950                 955                 960


Asn Phe Gln Met Val Pro Leu Asp Pro Lys Gly Thr Thr Gln Ile Asp 
                965                 970                 975


Pro Asn Trp Val Ile Arg His Gln Gly Lys Glu Leu Val Gln Thr Ala 
            980                 985                 990


Asn Ser Asp Pro Gly Ile Ala Val Gly Phe Asp Glu Phe Gly Ser Val 
        995                 1000                1005


Asp Phe Ser Gly Thr Phe Tyr Val Asn Thr Asp Arg Asp Asp Asp Tyr 
    1010                1015                1020


Ala Gly Phe Val Phe Gly Tyr Gln Ser Ser Ser Arg Phe Tyr Val Val 
1025                1030                1035                1040


Met Trp Lys Gln Val Thr Gln Thr Tyr Trp Glu Asp Gln Pro Thr Arg 
                1045                1050                1055


Ala Tyr Gly Tyr Ser Gly Val Ser Leu Lys Val Val Asn Ser Thr Thr 
            1060                1065                1070


Gly Thr Gly Glu His Leu Arg Asn Ala Leu Trp His Thr Gly Asn Thr 
        1075                1080                1085


Pro Gly Gln Val Arg Thr Leu Trp His Asp Pro Arg Asn Ile Gly Trp 
    1090                1095                1100


Lys Asp Tyr Thr Ala Tyr Arg Trp His Leu Thr His Arg Pro Lys Thr 
1105                1110                1115                1120


Gly Tyr Ile Arg Val Leu Val His Glu Gly Lys Gln Val Met Ala Asp 
                1125                1130                1135


Ser Gly Pro Ile Tyr Asp Gln Thr Tyr Ala Gly Gly Arg Leu Gly Leu 
            1140                1145                1150


Phe Val Phe Ser Gln Glu Met Val Tyr Phe Ser Asp Leu Lys Tyr Glu 
        1155                1160                1165


Cys Arg Asp Ile 
    1170


<210>  3498
<211>  1271
<212>  DNA
<213>  Homo sapiens

<400>  3498
cccaaaccca agtgccttca gaggataaat atcaatggaa ctcagagatg aacatctaac     60

ccactagagg aaaccagttt ggtgatatat gagactttat gtggagtgaa aattgggcat    120

gccattacat tgctttttct tgtttgttta aaaagaatga cgtttacata taaaatgtaa    180

ttacttattg tatttatgtg tatatggagt tgaagggaat actgtgcata agccattatg    240

ataaattaag catgaaaaat attgctgaac tacttttggt gcttaaagtt gtcactattc    300

ttgaattaga gttgctctac aatgacacac aaatcccatt aaataaatta taaacaaggg    360

tcaattcaaa tttgaagtaa tgttttagta aggagagatt agaagacaac aggcatagca    420

aatgacataa gctaccgatt aactaatcgg aacatgtaaa acagttacaa aaataaacga    480

actctcctct tgtcctacaa tgaaagccct catgtgcagt agagatgcag tttcatcaaa    540

gaacaaacat ccttgcaaat gggtgtgacg cggttccaga tgtggatttg gcaaaacctc    600

atttaagtaa aaggttagca gagcaaagtg cggtgcttta gctgctgctt gtgccgctgt    660

ggcgtcgggg aggctcctgc ctgagcttcc ttccccagct ttgctgcctg agaggaacca    720

gagcagacgc acaggccgga aaaggcgcat ctaacgcgta tctaggcttt ggtaactgcg    780

gacaagttgc ttttacctga tttgatgata catttcatta aggttccagt tataaatatt    840

ttgttaatat ttattaagtg actatagaat gcaactccat ttaccagtaa cttattttaa    900

atatgcctag taacacatat gtagtataat ttctagaaac aaacatctaa taagtatata    960

atcctgtgaa aatatgaggc ttgataatat taggttttct gtttctgtgt tgtggggtca   1020

accgtacaat ggtgtgggag tgacgatgat gtgagtattt agaatgtacc atattttttg   1080

taaattattt atgtttttct aaacaaattt atcgtatagg ttgatgaaac gtcatgtgtt   1140

ttgccaaaga ctgtaaatat ttatttatgt gttcacatgg tcaaaatttc accactgaaa   1200

ccctgcactt agctagaacc tcatttttaa agattaacaa caggaaataa attgtaaaaa   1260

aggttttcta t                                                        1271


<210>  3499
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  3499

Met Glu Leu Lys Gly Ile Leu Cys Ile Ser His Tyr Asp Lys Leu Ser 
1               5                   10                  15


Met Lys Asn Ile Ala Glu Leu Leu Leu Val Leu Lys Val Val Thr Ile 
            20                  25                  30


Leu Glu Leu Glu Leu Leu Tyr Asn Asp Thr Gln Ile Pro Leu Asn Lys 
        35                  40                  45


Leu 



<210>  3500
<211>  572
<212>  DNA
<213>  Homo sapiens

<400>  3500
catatagaat aatgaggagt ttatgatgga accttaaata tataatgttg ccagcgattt     60

tagttcaata tttgttactg ttatctatct gctgtatatg gaattctttt aattcaaacg    120

ctgaaaagaa tcagcattta gtcttgccag gcacacccaa taatcagtca tgtgtaatat    180

gcacaagttt gtttttgttt ttgttttttt tgttggttgg tttgtttttt tgctttaagt    240

tgcatgatct ttctgcagga aatagtcact catcccactc cacataaggg gtttagtaag    300

agaagtctgt ctgtctgatg atggataggg ggcaaatctt tttccccttt ctgttaatag    360

tcatcacatt tctatgccaa acaggaacaa tccataactt tagtcttaat gtacacattg    420

cattttgata aaattaattt tgttgtttcc tttgaggttg atcgttgtgt tgttgttttg    480

ctgcactttt tacttttttg cgtgtggagc tgtattcccg agaccaacga agcgttggga    540

tacttcatta aatgtagcga ctgtcaacag cg                                  572


<210>  3501
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  3501

Met Leu Pro Ala Ile Leu Val Gln Tyr Leu Leu Leu Leu Ser Ile Cys 
1               5                   10                  15


Cys Ile Trp Asn Ser Phe Asn Ser Asn Ala Glu Lys Asn Gln His Leu 
            20                  25                  30


Val Leu Pro Gly Thr Pro Asn Asn Gln Ser Cys Val Ile Cys Thr Ser 
        35                  40                  45


Leu Phe Leu Phe Leu Phe Phe Leu Leu Val Gly Leu Phe Phe Cys Phe 
    50                  55                  60


Lys Leu His Asp Leu Ser Ala Gly Asn Ser His Ser Ser His Ser Thr 
65                  70                  75                  80


<210>  3502
<211>  748
<212>  DNA
<213>  Homo sapiens

<400>  3502
aaggcacacc gcttacaggc aaatacccct ctaggcggca cagcctgatc tctctccgct     60

tcttgtgtta gtccggcagg acggcggctg gagccactgg tcaccttggt cttcatgctc    120

tgtgacctgt ggagttggca atatcacacg catccgtctc tgcaactccc cagtgcccca    180

gatggggggc aagaattgca aagggagtgg ccgggagacc aaagcctgcc agggcgcccc    240

atgcccaatc gatggccgct ggagcccctg gtccccgtgg tcggcctgca ctgtcacctg    300

tgccggtggg atccgggagc gcacccgggt ctgcaacagc cctgagcctc agtacggagg    360

gaaggcctgc gtgggggatg tgcaggagcg tcagatgtgc aacaagagga gctgccccgt    420

gggtgagtga ggggtagaag cgggggcact gaaacccggg cttccattct gatgaaaagc    480

acaaacgctt tgggaaacta gatgaaaaac acagaaaaga aaaatcaatt ttagttgcac    540

acgcaaagat aactactttt aacatctgtg tttcagtcct cctgtatttc taatgtaaaa    600

acaaaaaaga tgccaggtgg cgtggcctgt ggaatgtggg tagttgtgtg gcgtggaatg    660

tggtgtgtgg gtaattgtgt ggtgtggcct gtggaatgtg ggtagttgtg tggcgtggcc    720

tgtggaatgt gggcagttgt gtggcatg                                       748


<210>  3503
<211>  82
<212>  PRT
<213>  Homo sapiens

<400>  3503

Met Gly Gly Lys Asn Cys Lys Gly Ser Gly Arg Glu Thr Lys Ala Cys 
1               5                   10                  15


Gln Gly Ala Pro Cys Pro Ile Asp Gly Arg Trp Ser Pro Trp Ser Pro 
            20                  25                  30


Trp Ser Ala Cys Thr Val Thr Cys Ala Gly Gly Ile Arg Glu Arg Thr 
        35                  40                  45


Arg Val Cys Asn Ser Pro Glu Pro Gln Tyr Gly Gly Lys Ala Cys Val 
    50                  55                  60


Gly Asp Val Gln Glu Arg Gln Met Cys Asn Lys Arg Ser Cys Pro Val 
65                  70                  75                  80


Gly Glu 



<210>  3504
<211>  2896
<212>  DNA
<213>  Homo sapiens

<400>  3504
ggcaggagtg cagatgtgat ctcggcacac cgcaacctct gcctcttgga ttcaagcaat     60

tctcctgcct cagcctccca agtggctggg attacaggca tgcgccacca cgcccagggt    120

ttggcaaatg gattctgcag agtcagatgc cttaacttcg tgtagtggtc ttgtggatgg    180

cttactgcct tggagttaat ttcgttcctt ctcgtttctg ctaccagctt cacaggcttc    240

tgctaaggtg taccttccgg tttcccagca cggccatcaa gatccagttc acgtcgctct    300

atcacaaaga agaggcccca gcctccccgc tgcggccact gtacccccag atctcccctc    360

tgaagatcca catcccggag ccggacctcc ggagcatggt cagccccgtc ccctccccga    420

cgggcaccat cagtgtcccc aactcctgcc cagccagtcc acgcggtgcc ggctcctcca    480

gttaccgctt tgtgcagaac gtgacctcgg acctgcagct ggcagcagag tttgcagcaa    540

aggccgcgtc ggagcagcag gcagacacgt ctggaggaga cagccccaag gatgagtcaa    600

agccgccgtt ctcctacgcg cagctgatcg tgcaggccat ctcctccgcc caggaccggc    660

agctgaccct gagcgggatc tacgcccaca tcaccaagca ttacccctac taccggacgg    720

ccgacaaagg ctggcagaat tctatccggc acaacctctc tttgaaccgt tactttatca    780

aagtcccacg ttcccaggag gagcctggga aggggtcctt ttggcgaata gaccctgcct    840

ctgaagccaa gctcgtggaa caggcattcc ggaaacggag gcagaggggt gtctcctgct    900

tccgcacccc cttcgggcct ctgtcctcaa ggagcgctcc agcttcgccc acacaccccg    960

ggctgatgtc ccctcgctcc ggcggcctgc agaccccaga gtgcctgtct cgggagggct   1020

cccccattcc acacgaccct gagtttgggt ccaagttagc ttctgtccca gagtaccggt   1080

attcccaaag cgcacccggc tcccccgtca gcgcccagcc agtgatcatg gccgtgcctc   1140

cccgaccgtc cagcctcgtg gccaagcccg tggcctacat gcccgcctcc atcgtaacct   1200

cacagcagcc cgcgggccac gccatccacg tcgtgcagca ggcccccacc gtcaccatgg   1260

tcagggtggt caccacatct gccaactcgg ccaacggata catcctcacc agccagggcg   1320

cggcgggggg ctcccatgat gcggcgggcg cagccgtgct ggacctgggc agcgaggcca   1380

gaggcctgga ggagaaaccc accattgcgt ttgccacaat ccccgcggct ggtggagtca   1440

tccagacggt ggccagccag atggcccccg gggtccccgg acacacggtc accatcctgc   1500

agcccgccac acccgtgacc ctcgggcagc accaccttcc agtccgggcc gtgacccaga   1560

acggaaagca tgcggttccc acgaacagtt tagccggcaa cgcttacgcc ctcaccagcc   1620

ctttgcagct ccttgcgacc caagcgagtt catccgcgcc ggtggtggtc acccgggtgt   1680

gcgaggtggg gcccaaggag ccagcagcag ccgtcgcggc cacggccacc accaccccag   1740

ccactgccac caccgcctct gcctccgcct cttccactgg agagcccgag gtcaaaaggt   1800

cccgggtgga ggagcccagt ggtgctgtaa ccacaccggc tggagtgatc gcagctgccg   1860

gcccccaggg gccaggcacc ggggagtgag gtcacctgca acgcggggga gtgggactca   1920

cccagcggcg accccgaagc tggacccggc agctcaggcg gccgcaccca cagacggagg   1980

agaacagccc gcggcggcct gtgggcatcg gcggcacctg gacacaccca gccctttcca   2040

tttgatcgcc tgccttcccg tggtttaaga caaaaacaca taaacaagtt cagacaactg   2100

attgtatgat tctgggaatt ctttgctttc ctttccttct ccctcggcac cacctcctct   2160

ccccaggcct ccctgtcggg catggggagg aggttggagc tcagcatctt gaggaatgtg   2220

tcaagacagc ccctccgctc cgcgctgcac ggccagccgc ctttgtccgg gaggacagac   2280

agaaacgcag caaggcacac accaaggctg ccggggaggc ccgggcaccg gacagatgcc   2340

tgttgggaag ccaggagctg ccgagccacg gaccacctaa cagcctctcc gcccggaacg   2400

tgacatagag agtgttggca ttaactcggg gggtgtccga tttcacttca gaccccaagt   2460

ttttctttgt ttgtttaaac atggaattca gacttcattg tacacctgag acagacacaa   2520

aagggatcat gtatttttga ggattttacc tgttgacgtc tgatgaccgg ccgtaggtcc   2580

agggttcccg ctgggtttaa tcccctcgaa gagtaaacct gccgctctgt ctgataactt   2640

caagtaagag cagcggcttc ctgggttggc gttcgcggtg gaaggttcct aggatgaaag   2700

gtgagcctgg atccgccggc cgcagacatc gcgctgctgg ggacgattgg ggccgctgct   2760

ctgcagacca gaccttcccg aattatccgt ggctccgatg tcccggtgct gacggccaca   2820

tggggaccta acagtgccaa acgccatctg ctccagctgc tttttcaccc agttgcagag   2880

tcctcaccac tcccac                                                   2896


<210>  3505
<211>  570
<212>  PRT
<213>  Homo sapiens

<400>  3505

Met Ala Tyr Cys Leu Gly Val Asn Phe Val Pro Ser Arg Phe Cys Tyr 
1               5                   10                  15


Gln Leu His Arg Leu Leu Leu Arg Cys Thr Phe Arg Phe Pro Ser Thr 
            20                  25                  30


Ala Ile Lys Ile Gln Phe Thr Ser Leu Tyr His Lys Glu Glu Ala Pro 
        35                  40                  45


Ala Ser Pro Leu Arg Pro Leu Tyr Pro Gln Ile Ser Pro Leu Lys Ile 
    50                  55                  60


His Ile Pro Glu Pro Asp Leu Arg Ser Met Val Ser Pro Val Pro Ser 
65                  70                  75                  80


Pro Thr Gly Thr Ile Ser Val Pro Asn Ser Cys Pro Ala Ser Pro Arg 
                85                  90                  95


Gly Ala Gly Ser Ser Ser Tyr Arg Phe Val Gln Asn Val Thr Ser Asp 
            100                 105                 110


Leu Gln Leu Ala Ala Glu Phe Ala Ala Lys Ala Ala Ser Glu Gln Gln 
        115                 120                 125


Ala Asp Thr Ser Gly Gly Asp Ser Pro Lys Asp Glu Ser Lys Pro Pro 
    130                 135                 140


Phe Ser Tyr Ala Gln Leu Ile Val Gln Ala Ile Ser Ser Ala Gln Asp 
145                 150                 155                 160


Arg Gln Leu Thr Leu Ser Gly Ile Tyr Ala His Ile Thr Lys His Tyr 
                165                 170                 175


Pro Tyr Tyr Arg Thr Ala Asp Lys Gly Trp Gln Asn Ser Ile Arg His 
            180                 185                 190


Asn Leu Ser Leu Asn Arg Tyr Phe Ile Lys Val Pro Arg Ser Gln Glu 
        195                 200                 205


Glu Pro Gly Lys Gly Ser Phe Trp Arg Ile Asp Pro Ala Ser Glu Ala 
    210                 215                 220


Lys Leu Val Glu Gln Ala Phe Arg Lys Arg Arg Gln Arg Gly Val Ser 
225                 230                 235                 240


Cys Phe Arg Thr Pro Phe Gly Pro Leu Ser Ser Arg Ser Ala Pro Ala 
                245                 250                 255


Ser Pro Thr His Pro Gly Leu Met Ser Pro Arg Ser Gly Gly Leu Gln 
            260                 265                 270


Thr Pro Glu Cys Leu Ser Arg Glu Gly Ser Pro Ile Pro His Asp Pro 
        275                 280                 285


Glu Phe Gly Ser Lys Leu Ala Ser Val Pro Glu Tyr Arg Tyr Ser Gln 
    290                 295                 300


Ser Ala Pro Gly Ser Pro Val Ser Ala Gln Pro Val Ile Met Ala Val 
305                 310                 315                 320


Pro Pro Arg Pro Ser Ser Leu Val Ala Lys Pro Val Ala Tyr Met Pro 
                325                 330                 335


Ala Ser Ile Val Thr Ser Gln Gln Pro Ala Gly His Ala Ile His Val 
            340                 345                 350


Val Gln Gln Ala Pro Thr Val Thr Met Val Arg Val Val Thr Thr Ser 
        355                 360                 365


Ala Asn Ser Ala Asn Gly Tyr Ile Leu Thr Ser Gln Gly Ala Ala Gly 
    370                 375                 380


Gly Ser His Asp Ala Ala Gly Ala Ala Val Leu Asp Leu Gly Ser Glu 
385                 390                 395                 400


Ala Arg Gly Leu Glu Glu Lys Pro Thr Ile Ala Phe Ala Thr Ile Pro 
                405                 410                 415


Ala Ala Gly Gly Val Ile Gln Thr Val Ala Ser Gln Met Ala Pro Gly 
            420                 425                 430


Val Pro Gly His Thr Val Thr Ile Leu Gln Pro Ala Thr Pro Val Thr 
        435                 440                 445


Leu Gly Gln His His Leu Pro Val Arg Ala Val Thr Gln Asn Gly Lys 
    450                 455                 460


His Ala Val Pro Thr Asn Ser Leu Ala Gly Asn Ala Tyr Ala Leu Thr 
465                 470                 475                 480


Ser Pro Leu Gln Leu Leu Ala Thr Gln Ala Ser Ser Ser Ala Pro Val 
                485                 490                 495


Val Val Thr Arg Val Cys Glu Val Gly Pro Lys Glu Pro Ala Ala Ala 
            500                 505                 510


Val Ala Ala Thr Ala Thr Thr Thr Pro Ala Thr Ala Thr Thr Ala Ser 
        515                 520                 525


Ala Ser Ala Ser Ser Thr Gly Glu Pro Glu Val Lys Arg Ser Arg Val 
    530                 535                 540


Glu Glu Pro Ser Gly Ala Val Thr Thr Pro Ala Gly Val Ile Ala Ala 
545                 550                 555                 560


Ala Gly Pro Gln Gly Pro Gly Thr Gly Glu 
                565                 570


<210>  3506
<211>  391
<212>  DNA
<213>  Homo sapiens

<400>  3506
gctgcatgag aagggctggc cgctccttaa agcaaagcct gactcctgtt agcagaaggg     60

gcaatgaatg ctgagcaggc gaaaactaga tgttcactgc ctcattccag ccagatgtcg    120

tcagtgacct gtgctcccga gcttcatttt tgttttttaa aagactcttt agtttatctt    180

tatttattta ttttagagat ggggtcccac tctctcaccc aggctggagc acagtgctgc    240

gatcatagct cactgcagcc ttgaactcct gggtgctagt ggtcctcctg actacaggca    300

cgtgccacca ggcccgctaa tttgttttgt tttgtttcgt tttttgagaa gagtgagaat    360

ctgtctcaaa aaaaattttt ttttaaatag t                                   391


<210>  3507
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  3507

Met Asn Ala Glu Gln Ala Lys Thr Arg Cys Ser Leu Pro His Ser Ser 
1               5                   10                  15


Gln Met Ser Ser Val Thr Cys Ala Pro Glu Leu His Phe Cys Phe Leu 
            20                  25                  30


Lys Asp Ser Leu Val Tyr Leu Tyr Leu Phe Ile Leu Glu Met Gly Ser 
        35                  40                  45


His Ser Leu Thr Gln Ala Gly Ala Gln Cys Cys Asp His Ser Ser Leu 
    50                  55                  60


Gln Pro 
65


<210>  3508
<211>  11191
<212>  DNA
<213>  Homo sapiens

<400>  3508
ccgcgcgaac atggccgaag tcggcgagga cagcggcgcc cgcgccctgc tcgcgctgcg     60

ctcggcgccc tgcagcccag tgctgtgcgc cgcagccgcc gccgccgcct tccccgcggc    120

cgcacccccg ccggcccccg cgcagcccca gcctccgccc gggccgccgc cgccgccgcc    180

accgccgctg cctccgggcg cgatcgcggg cgcgggctcc tccgggggct cctccggggt    240

atccggggac tccgcggtcg cgggcgcggc gccggccctg gtggccgcgg cggccgcctc    300

ggtacggcag agcccggggc cggcgctggc gcggctggag ggccgcgagt tcgagttcct    360

catgcgccag cccagcgtca ccatcggccg caactcgtcg cagggctcgg tggacttgag    420

catgggcctg tccagcttca tctcgcggcg ccacctgcag ctcagcttcc aggagccgca    480

cttctacctg cgctgcctcg gcaagaacgg cgtcttcgtg gacggggcct tccagagacg    540

cggcgcgccc gccctgcagc tgcccaagca gtgtaccttc cggtttccca gcacggccat    600

caagatccag ttcacgtcgc tctatcacaa agaagaggcc ccagcctccc cgctgcggcc    660

actgtacccc cagatctccc ctctgaagat ccacatcccg gagccggacc tccggagcat    720

ggtcagcccc gtcccctccc cgacgggcac catcagtgtc cccaactcct gcccagccag    780

tccacgcggt gccggctcct ccagttaccg ctttgtgcag aacgtgacct cggacctgca    840

gctggcagca gagtttgcag caaaggccgc gtcggagcag caggcagaca cgtctggagg    900

agacagcccc aaggatgagt caaagccgcc gttctcctac gcgcagctga tcgtgcaggc    960

catctcctcc gcccaggacc ggcagctgac cctgagcggg atctacgccc acatcaccaa   1020

gcattacccc tactaccgga cggccgacaa aggctggcag aattctatcc ggcacaacct   1080

ctctttgaac cgttacttta tcaaagtccc acgttcccag gaggagcctg ggaaggggtc   1140

cttttggcga atagaccctg cctctgaagc caagctcgtg gaacaggcat tccggaaacg   1200

gaggcagagg ggtgtctcct gcttccgcac ccccttcggg cctctgtcct caaggagcgc   1260

tccagcttcg cccacacacc ccgggctgat gtcccctcgc tccggcggcc tgcagacccc   1320

agagtgcctg tctcgggagg gctcccccat tccacacgac cctgagtttg ggtccaagtt   1380

agcttctgtc ccagagtacc ggtattccca aagcgcaccc ggctcccccg tcagcgccca   1440

gccagtgatc atggccgtgc ctccccgacc gtccagcctc gtggccaagc ccgtggccta   1500

catgcccgcc tccatcgtaa cctcacagca gcccgcgggc cacgccatcc acgtcgtgca   1560

gcaggccccc accgtcacca tggtcagggt ggtcaccaca tctgccaact cggccaacgg   1620

atacatcctc accagccagg gcgcggcggg gggctcccat gatgcggcgg gcgcagccgt   1680

gctggacctg ggcagcgagg ccagaggcct ggaggagaaa cccaccattg cgtttgccac   1740

aatccccgcg gctggtggag tcatccagac ggtggccagc cagatggccc ccggggtccc   1800

cggacacacg gtcaccatcc tgcagcccgc cacacccgtg accctcgggc agcaccacct   1860

tccagtccgg gccgtgaccc agaacggaaa gcatgcggtt cccacgaaca gtttagccgg   1920

caacgcttac gccctcacca gccctttgca gctccttgcg acccaagcga gttcatccgc   1980

gccggtggtg gtcacccggg tgtgcgaggt ggggcccaag gagccagcag cagccgtcgc   2040

ggccacggcc accaccaccc cagccactgc caccaccgcc tctgcctccg cctcttccac   2100

tggagagccc gaggtcaaaa ggtcccgggt ggaggagccc agtggtgctg taaccacacc   2160

ggctggagtg atcgcagctg ccggccccca ggggccaggc accggggagt gaggtcacct   2220

gcaacgcggg ggagtgggac tcacccagcg gcgaccccga agctggaccc ggcagctcag   2280

gcggccgcac ccacagacgg aggagaacag cccgcggcgg cctgtgggca tcggcggcac   2340

ctggacacac ccagcccttt ccatttgatc gcctgccttc ccgtggttta agacaaaaac   2400

acataaacaa gttcagacaa ctgattgtat gattctggga attctttgct ttcctttcct   2460

tctccctcgg caccacctcc tctccccagg cctccctgtc gggcatgggg aggaggttgg   2520

agctcagcat cttgaggaat gtgtcaagac agcccctccg ctccgcgctg cacggccagc   2580

cgcctttgtc cgggaggaca gacagaaacg cagcaaggca cacaccaagg ctgccgggga   2640

ggcccgggca ccggacagat gcctgttggg aagccaggag ctgccgagcc acggaccacc   2700

taacagcctc tccgcccgga acgtgacata gagagtgttg gcattaactc ggggggtgtc   2760

cgatttcact tcagacccca agtttttctt tgtttgttta aacatggaat tcagacttca   2820

ttgtacacct gagacagaca caaaagggat catgtatttt tgaggatttt acctgttgac   2880

gtctgatgac cggccgtagg tccagggttc ccgctgggtt taatcccctc gaagagtaaa   2940

cctgccgctc tgtctgataa cttcaagtaa gagcagcggc ttcctgggtt ggcgttcgcg   3000

gtggaaggtt cctaggatga aaggtgagcc tggatccgcc ggccgcagac atcgcgctgc   3060

tggggacgat tggggccgct gctctgcaga ccagaccttc ccgaattatc cgtggctccg   3120

atgtcccggt gctgacggcc acatggggac ctaacagtgc caaacgccat ctgctccagc   3180

tgctttttca cccagttgca gagtcctcac cactcccaca ttgatctgct gttttcaatt   3240

ggaaccattt ctcctgcctg aaactccagg gcccctccct gggctgtccg tgagcaggag   3300

accccacccc agcagcagtg gtgagcaggc ctgtgcctcc acgcccagcc cccgccaacg   3360

cgactggttt tgtttgccac acggtgagaa ccggaggacg ggatgctcca gccagttggg   3420

tggttctggg gtccctgagg aagccccctc ctgcacttcc attaagacag ccagtggttc   3480

ctggatcttt gtcaccaagc agcgttgagc cagagctgtc taatgctgag cccagctcag   3540

gaaggagaga ggagtccttc agtgtgtctt ggagatgcga agtgcgtcct cgtaaaggtc   3600

agctgtcagt tttgctggcc gctccggcgc tggctctcct gtccgggacc acaacgagaa   3660

acagcgacag attcgacgca gagctccgga agtgcctgag gagcagtggt tcttggaaat   3720

cgcccgtcct ccgcatcaca gcctctcacc agcaaagcag cctctgccca ggccctggcg   3780

ggagagctgc agagggaccc aggtgcctgg agggcatttg agggaggtgg ctggacaggt   3840

gtctccctga agaagaaggg agaacacttt tcaaagtgat tccgaggcag tgcgggagga   3900

cacacgtgct gtgcagtgga gtggggtcgc ccgtggcccc catcagagtc cccgtccccc   3960

aggacaagtg cagaacctct gtgggccccc tccttccacc tagatagaga aaaccccttg   4020

ttcggtttcc ttcccgtgtc ccgttgtttt tctaagcccc ccgaattgag tcgtttctat   4080

ggcactaacc tttccatggg aaataagctc tttgtggaag tccgtacctg ttgccctggg   4140

tgaggtttca gagaaacggg ggcaggatga acacagccgg ctgtcctggg tgcagttacg   4200

tccgtggagg gtgagagatt gcgccccgtt ccacacttgt gtcgcctgct gttgtctgtg   4260

ggccttttct ttccgtggtg cctggtgtgt gcgtgcatgg cgtgagagaa cggggggtgg   4320

gggttggagg tggctccccg acaccggtgc ctgtgtggcc tgagccggcg ccctcccggg   4380

agcgcccgtc acggggggcc tctgtgatta cctgctgctg ctctctcccg cgtggtgact   4440

atatgtcctc agggctgcct gtggccaccc tgatgggaga cctctgtttg cttctgggcc   4500

actgcaggtt ggcctcctca atacaagctg atgtctgcag ggagcgccgc gtgctgggat   4560

tgcaccacgt gttggtcaca aatcgaggtc gccttttggc ctggtctgct caggctggcc   4620

ctgacccacg tggtttcctg gcttctgaga cgcagcgcat tcttcctgtt agcggtagcg   4680

ttctctgatt tcactgcttc attgccaagg gcgtggaaag ggggtggtgg atggagccgg   4740

gaggtggcga gcacaggacc ccggggctgc attctgccgt gtggggttct gcactgtcta   4800

gcttctgcgg ggactgcaaa gagggatgaa gggacgtggt cctaggggtc ggctcagact   4860

cggagcaggg cagggagagg agggcaagga gaggaggcct gggtcctgga tccactgctc   4920

tgggctcata accatgagat tttgaaagag tttttggtca tctgagcagg taccatgcct   4980

ggctcatgcc ggaacttgtc ttggaaccgg tagccagagg cccaggaagg gacagggccc   5040

aaaagggttg catgtcccgg ccacaaagcc ctccctgtgt gccctgagcc agcccagcaa   5100

gcgcctccca gccaggcgct ttcgcagaag caagagcaca ggccaggggg accgggagag   5160

cctcagcccc cagcctgggc ggcctgtgac cctgagccgt gtggagccag gacccaagaa   5220

ccttctctag gttctcaagg gtgagctgac ccgggcaatg tgcaggaatg tggggagcaa   5280

aagtagctga ttccagcccc gttctggggt cactggggag gcagaggctg agggcctgtt   5340

ctctggtcac cagggactgg gggcacggtc cacagcggat gagaacagca ggtcacagta   5400

gtggctttgg gaagggcccc tcctgctttg ccctgttcgg aaaggggctc cctcagagcc   5460

cctgggccca gtaacccgct tctgtctcct gactcctgct ggataaattg ccaggtttat   5520

caaatacaag aaaacacctg ctttggctag gaggtaagtc ccaaaaagaa cgtcttaagt   5580

agagcaaagg catccaccga ggccatttgg tggcccctgg gaagtgggga agcagggcct   5640

gagcgtcccc aggctgctag ggcagcagct ggctcagggc acactctctc gtgccagctt   5700

ctgccaccag cccagtgtcc acggagccgc ggggccagag gagctcaggg agacctggct   5760

gtctagggca tggtacccag tatcccggtg tgtgcccatc ctcagccact tgtgtctttc   5820

tttccatgtg ggagttctcc cggtgacacc tgccctccgt tgagggtgga atctgtcact   5880

catgcctttg agggacccag atggaccatc cctcttctgc ttgctttcta cattcctaaa   5940

aacctcaacg ttaatccctc accagtcggg ccgagtgtgg cctcatggtt ctgccgcggc   6000

ccagtcttct cccactggct tcacgctaga gggcgccatg cgctctgggt gaaatgagac   6060

gctggtgtgg ggtccccatg tagagaccct caggtcccta tccagagacc ctccaggcag   6120

tgctgggaag acactggtgg cggggaccat gaccaggcgg gtggagccat gtgtgtctca   6180

cacctgccgc ccctcacttt ccttcccgag gtctggtagg tcctctttgg gatttgctgt   6240

ttatttgtat ctcccttttc tttgatttaa gaacaatgcc aagtgaaaaa gctgggaatg   6300

aatttctgag ttgctgagtg ttccctgctc ctaggtacca cgctctgtgc ttctcaggca   6360

gggaggagat ggattcggtg gagttgggcc aggacggggg cttcaccctg ccccctccag   6420

actgccgaag cccccaagaa gttttgagcc cagctgggcc tcgcctcccc ggctcctggg   6480

tccattttct gtactggttt gagatcacag gcatcattca gcgaatgctc ttgtgtcctc   6540

tgcataaaga gggccctccc tggagcaccc ccggggagct gggactctcc agaaagcccc   6600

gggtgagggc tccgtcttga gagagagaga aatcccttct ttgggcgatt cagtgagttc   6660

aggaggagga ggaagctttt ccttggcttt gaaatcagtg tttttatgga gacaaagaac   6720

agacctcagt gggaaaaatg aaaacgtaat ggaacacggg gaggtgtcgg agaagaaagg   6780

attttcccct tcgctttcag agccggcggg agtgcaggtc tgttttgctt cagaagcctc   6840

acattctgct ttgcccttga gtgacttcat gcgggatgag gaactgttga cccctctaga   6900

gaggacaccc caagtccatc ctgggctcct cctcacccct ctgagaaagc ccccctaaaa   6960

aaaggcttca gagtcaccgg catgccgcct cacgttgcag gacggaatcg cgcgctcctc   7020

acgctggagt aagttacgaa acatgatcgt caggctcttt gcaaacgcag agccccagaa   7080

cgctggatgg aggcctcctc ggccctgcgg gcggcctggc tgcggtaggt ctgctgcaag   7140

gagccaccac ggggactgcg ccacactcct gatgaaaacg tgtttaccca cagcctcgcc   7200

tcgagcctcc ttgacaatac cgctgcttca aagcaatatt atttaatgag aatactttac   7260

attgctcaca tgtgctgcta tgaagacagg attagtctgt agacgggact cagctccaga   7320

ggttcctggg taatgtattg tggctcttgg aaatgagggt agaatttgaa atataacaaa   7380

tggtctctcg cccggttctg tcccttattt ttagattgtt ttcctgcatc ttacaatttc   7440

cttttctttt caaagttcct ttctccaggc ctgtttttca gtgctcagga cacggttttc   7500

atcacatact tactgttttt ttggttgggt tttgatacga aaagctgcta cgtttggtga   7560

ccagagggag ggtttggaat ctgtgctttg caggggatct cggtgggtac cgcggcccct   7620

cgcagggtgg cgagtggggt ccgtgcctcg agaagggggc ccttacccac accgtgcggc   7680

ttgaattctg tcggagttga atctgtggaa aggattgtcc cattagagct gctgcgtcct   7740

ttcctctgtc ctccctgtca cccaaacccc gaagtcacag ctgcttagaa gaatgggatt   7800

ttggggatac aaccacacac atttccctct ggactgaaat tttaaaaaca gacccatttc   7860

actgacttct tttttttttt tttttttttt ttttttttga gacggagtct cgctctgtcg   7920

cccaggctgg agtgcagtgg cgtgatctcg gctcactgca agctccgcct cccgggttca   7980

cgccattctc ctgcctcagc ctcccgagta gctgggacta caggcgcccg ctaccacgcc   8040

cggctaattt tttgtatttt tagtagagac ggggtttcac cgtgttagcc aggatggtct   8100

cgatctcctg acctcgtgat ccgcccgcct cggcctccca aagtgctggg attacaggcg   8160

tgagccaccg cgcccggccc actgacttct ttagggaaaa tagtttcagt cttgggttgt   8220

cttgtgagcc cacgggcatg ggaccctgtc tctgctgggc ttttccggcc ccgtcccagc   8280

tcctcctcag gcagaggctg cagccctcag ctctgctgct ggatggaaca tttcaacccc   8340

ctccgggaag gtgggcaggg tggagggccc agggctaggc ctgccatgca ccatgagcag   8400

gggtgctacc tgggtgtgtg aagttgggct ggcttttcct ggaggtgggt gagaaggctc   8460

tccgggcaaa tcagaaggcc acgagagaga gaggagcggg gagagtggtg aggaggattc   8520

gtctctgact gatgaacctc gccgtgcctg tctgtcacat ccaagtctgt gccagctgct   8580

gggaggtcag actcctgccc tgagaaacag cccagtcctt ggagaatgaa accctgaggg   8640

tcagtgagtg gaggccttcc ctcggggcca gccattcccg ggaggcctga gtgtgacctg   8700

gaagctctgt gggtcaccaa gactggcatt ttccttgtat ttttgtgcag ggctgaagtg   8760

agcgttcctc ctctgaattg gtgaggcttt ggaaattttt tgtttcttct actcatccta   8820

atggctggtt ttggctgccc ggagtatcag agaatatcac taagagggca gtcagtttat   8880

ttttaggcat ctttctttct gtccagggag aaacccctcg gaagaatctt agtcactctt   8940

tgcacctgcc ctgtcattct cgccatgggg aaaatgcgtt gaaaagaaaa ataccggggc   9000

cagggagaag ccgtgaatgt atttatttgc tttggtgaag ctgctgaaca ctggctgcgg   9060

agggcccccc gcccccatcc cgcttcaggc cccagtgacc cagttgcgtc ttaagttcca   9120

tcgtccagat ttcaggccac cagaggctgc caaaggtgac tgaagcggtc tccaagtcac   9180

tctgtcacca cttttttttt ttttgagatg gagtctcgct ctatcgccca ggctggagtg   9240

cagtggccca atctcggctc actgcaacct ccgcctccca ggttcgagcg aattctcctg   9300

cctcaacctc ccaagtagct gggattacag gcacctgcca ccacacccgg ctaatttttg   9360

tatttctaat agagatgaga gtgttaccat gttggtcagg ctggtcttga actcctgacc   9420

tcaggtgatc tgcccacctc aacctcccaa agtgctggga ttataggcat gagccaccgc   9480

gcctggcctc tgtcactttt tttgctcctt acccagtttt tgttttttgt tgttttgttt   9540

tgttttagcg tgatactaca atggaaagac tcctagttgg ttattcttta tctcggattc   9600

ttttttctgg aattgtttgc tcatttgagt ggttggtggt ttgccctgtg tcagacacgg   9660

tgaaaagagt gcaggaaagc tggggccagg ggaagcgaag tggcttcaat ccgggctgac   9720

agccaagaag agttttcctc ccttcggtga cagggcctgc ccctccgagt ctagaggtaa   9780

aagcagcttc tagaactggc ccctaagtct ccaaatgtgt tggctaagct gaaatgagag   9840

actctgaatt agagtttttg tttgtttgtt tgttctctgc atgaagttca caggcctgta   9900

tggatgttaa attgtgtcta tagcctctaa atctccaggt taactggtcc agattttttt   9960

tttttaatca gtaacaatgg gaatttaaaa tcaaatattt ggccaggtgc ggtggctcat  10020

gcccgtaatc ccagcacttt gggaggccga ggcaggcgca tcacctgagg agtttgagac  10080

cagcctgacc aacatggtga aatcctgtct ctactaaaaa tacaaaaaat tagccaggcg  10140

tggtggcgtg tgcctgtaat cccagctacc agggaggctg aggcatgaga atcgcttgaa  10200

cctgggagat ggaggttgca gtgagccgag atcatgccac tgcactccag cctgggcaac  10260

agagggagac tctgtctcaa aaataataat caaatcaagt attttaagtt tggctcttct  10320

ttttttcaag aaaggctttt tggataccta gaataccttc atgtatgtgg cttgatttct  10380

gtttcaggaa aaggggggcg ggaggagaga caacagccgt gttccagagt ctgtcctgag  10440

atgtcgctga gtccagacac ttgggctgca cgtgccctgc agatgacaaa ggccggcagc  10500

tcagcacacg tgcaggaggg gttaaagcca atattgagtt tttgttcttg ttgttttaat  10560

ctgaacgatt attctcctgt aaaaataatt tgggaggggc gggtgttgtt cggtgtgtgt  10620

gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt attttttttt ttacagtggc gcctgtctaa  10680

agtatttttc acaacatgtt tgataatcag tgctttaaaa agcagcagtg tcctatgaag  10740

tggaaatgtc agttctagag cattggatgt gaagttctgg tcatgtcacc ttgcgtgtct  10800

caccctggag gagtgaaggt gggcgcccgg cgggggggtg tggctgcacc ccagcaccgg  10860

gagggggcac gcacgacacc agaggaaggg acagccccac ccatgtcaac agcaggcaac  10920

ctgtgttttc atttcaagtg ggatacagta tttttttaat aaggagccat actttttttt  10980

aagagtttga gatctgaatg tgatttctaa ttgtatcaga cgttaatgtt ttaaagctat  11040

aacaaagttt aaaatttcta ctttttgttt ttcatttatt ttaactgttc ttttatctat  11100

taaattgttg tatgtggatg gggaagtttt gtttctcctc ttagcatttg tttctataac  11160

cagaaataaa attctatatt aaagaaatga c                                 11191


<210>  3509
<211>  733
<212>  PRT
<213>  Homo sapiens

<400>  3509

Met Ala Glu Val Gly Glu Asp Ser Gly Ala Arg Ala Leu Leu Ala Leu 
1               5                   10                  15


Arg Ser Ala Pro Cys Ser Pro Val Leu Cys Ala Ala Ala Ala Ala Ala 
            20                  25                  30


Ala Phe Pro Ala Ala Ala Pro Pro Pro Ala Pro Ala Gln Pro Gln Pro 
        35                  40                  45


Pro Pro Gly Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Pro Gly Ala 
    50                  55                  60


Ile Ala Gly Ala Gly Ser Ser Gly Gly Ser Ser Gly Val Ser Gly Asp 
65                  70                  75                  80


Ser Ala Val Ala Gly Ala Ala Pro Ala Leu Val Ala Ala Ala Ala Ala 
                85                  90                  95


Ser Val Arg Gln Ser Pro Gly Pro Ala Leu Ala Arg Leu Glu Gly Arg 
            100                 105                 110


Glu Phe Glu Phe Leu Met Arg Gln Pro Ser Val Thr Ile Gly Arg Asn 
        115                 120                 125


Ser Ser Gln Gly Ser Val Asp Leu Ser Met Gly Leu Ser Ser Phe Ile 
    130                 135                 140


Ser Arg Arg His Leu Gln Leu Ser Phe Gln Glu Pro His Phe Tyr Leu 
145                 150                 155                 160


Arg Cys Leu Gly Lys Asn Gly Val Phe Val Asp Gly Ala Phe Gln Arg 
                165                 170                 175


Arg Gly Ala Pro Ala Leu Gln Leu Pro Lys Gln Cys Thr Phe Arg Phe 
            180                 185                 190


Pro Ser Thr Ala Ile Lys Ile Gln Phe Thr Ser Leu Tyr His Lys Glu 
        195                 200                 205


Glu Ala Pro Ala Ser Pro Leu Arg Pro Leu Tyr Pro Gln Ile Ser Pro 
    210                 215                 220


Leu Lys Ile His Ile Pro Glu Pro Asp Leu Arg Ser Met Val Ser Pro 
225                 230                 235                 240


Val Pro Ser Pro Thr Gly Thr Ile Ser Val Pro Asn Ser Cys Pro Ala 
                245                 250                 255


Ser Pro Arg Gly Ala Gly Ser Ser Ser Tyr Arg Phe Val Gln Asn Val 
            260                 265                 270


Thr Ser Asp Leu Gln Leu Ala Ala Glu Phe Ala Ala Lys Ala Ala Ser 
        275                 280                 285


Glu Gln Gln Ala Asp Thr Ser Gly Gly Asp Ser Pro Lys Asp Glu Ser 
    290                 295                 300


Lys Pro Pro Phe Ser Tyr Ala Gln Leu Ile Val Gln Ala Ile Ser Ser 
305                 310                 315                 320


Ala Gln Asp Arg Gln Leu Thr Leu Ser Gly Ile Tyr Ala His Ile Thr 
                325                 330                 335


Lys His Tyr Pro Tyr Tyr Arg Thr Ala Asp Lys Gly Trp Gln Asn Ser 
            340                 345                 350


Ile Arg His Asn Leu Ser Leu Asn Arg Tyr Phe Ile Lys Val Pro Arg 
        355                 360                 365


Ser Gln Glu Glu Pro Gly Lys Gly Ser Phe Trp Arg Ile Asp Pro Ala 
    370                 375                 380


Ser Glu Ala Lys Leu Val Glu Gln Ala Phe Arg Lys Arg Arg Gln Arg 
385                 390                 395                 400


Gly Val Ser Cys Phe Arg Thr Pro Phe Gly Pro Leu Ser Ser Arg Ser 
                405                 410                 415


Ala Pro Ala Ser Pro Thr His Pro Gly Leu Met Ser Pro Arg Ser Gly 
            420                 425                 430


Gly Leu Gln Thr Pro Glu Cys Leu Ser Arg Glu Gly Ser Pro Ile Pro 
        435                 440                 445


His Asp Pro Glu Phe Gly Ser Lys Leu Ala Ser Val Pro Glu Tyr Arg 
    450                 455                 460


Tyr Ser Gln Ser Ala Pro Gly Ser Pro Val Ser Ala Gln Pro Val Ile 
465                 470                 475                 480


Met Ala Val Pro Pro Arg Pro Ser Ser Leu Val Ala Lys Pro Val Ala 
                485                 490                 495


Tyr Met Pro Ala Ser Ile Val Thr Ser Gln Gln Pro Ala Gly His Ala 
            500                 505                 510


Ile His Val Val Gln Gln Ala Pro Thr Val Thr Met Val Arg Val Val 
        515                 520                 525


Thr Thr Ser Ala Asn Ser Ala Asn Gly Tyr Ile Leu Thr Ser Gln Gly 
    530                 535                 540


Ala Ala Gly Gly Ser His Asp Ala Ala Gly Ala Ala Val Leu Asp Leu 
545                 550                 555                 560


Gly Ser Glu Ala Arg Gly Leu Glu Glu Lys Pro Thr Ile Ala Phe Ala 
                565                 570                 575


Thr Ile Pro Ala Ala Gly Gly Val Ile Gln Thr Val Ala Ser Gln Met 
            580                 585                 590


Ala Pro Gly Val Pro Gly His Thr Val Thr Ile Leu Gln Pro Ala Thr 
        595                 600                 605


Pro Val Thr Leu Gly Gln His His Leu Pro Val Arg Ala Val Thr Gln 
    610                 615                 620


Asn Gly Lys His Ala Val Pro Thr Asn Ser Leu Ala Gly Asn Ala Tyr 
625                 630                 635                 640


Ala Leu Thr Ser Pro Leu Gln Leu Leu Ala Thr Gln Ala Ser Ser Ser 
                645                 650                 655


Ala Pro Val Val Val Thr Arg Val Cys Glu Val Gly Pro Lys Glu Pro 
            660                 665                 670


Ala Ala Ala Val Ala Ala Thr Ala Thr Thr Thr Pro Ala Thr Ala Thr 
        675                 680                 685


Thr Ala Ser Ala Ser Ala Ser Ser Thr Gly Glu Pro Glu Val Lys Arg 
    690                 695                 700


Ser Arg Val Glu Glu Pro Ser Gly Ala Val Thr Thr Pro Ala Gly Val 
705                 710                 715                 720


Ile Ala Ala Ala Gly Pro Gln Gly Pro Gly Thr Gly Glu 
                725                 730


<210>  3510
<211>  11560
<212>  DNA
<213>  Homo sapiens

<400>  3510
ccgcgcgaac atggccgaag tcggcgagga cagcggcgcc cgcgccctgc tcgcgctgcg     60

ctcggcgccc tgcagcccag tgctgtgcgc cgcagccgcc gccgccgcct tccccgcggc    120

cgcacccccg ccggcccccg cgcagcccca gcctccgccc gggccgccgc cgccgccgcc    180

accgccgctg cctccgggcg cgatcgcggg cgcgggctcc tccgggggct cctccggggt    240

atccggggac tccgcggtcg cgggcgcggc gccggccctg gtggccgcgg cggccgcctc    300

ggtacggcag agcccggggc cggcgctggc gcggctggag ggccgcgagt tcgagttcct    360

catgcgccag cccagcgtca ccatcggccg caactcgtcg cagggctcgg tggacttgag    420

catgggcctg tccagcttca tctcgcggcg ccacctgcag ctcagcttcc aggagccgca    480

cttctacctg cgctgcctcg gcaagaacgg cgtcttcgtg gacggggcct tccagagacg    540

cggcgcgccc gccctgcagc tgcccaagca gtgtaccttc cggtttccca gcacggccat    600

caagatccag ttcacgtcgc tctatcacaa agaagaggcc ccagcctccc cgctgcggcc    660

actgtacccc cagatctccc ctctgaagat ccacatcccg gagccggacc tccggagcat    720

ggtcagcccc gtcccctccc cgacgggcac catcagtgtc cccaactcct gcccagccag    780

tccacgcggt gccggctcct ccagttaccg ctttgtgcag aacgtgacct cggacctgca    840

gctggcagca gagtttgcag caaaggccgc gtcggagcag caggcagaca cgtctggagg    900

agacagcccc aaggatgagt caaagccgcc gttctcctac gcgcagctga tcgtgcaggc    960

catctcctcc gcccaggacc ggcagctgac cctgagcggg atctacgccc acatcaccaa   1020

gcattacccc tactaccgga cggccgacaa aggctggcag aattctatcc ggcacaacct   1080

ctctttgaac cgttacttta tcaaagtccc acgttcccag gaggagcctg ggaaggggtc   1140

cttttggcga atagaccctg cctctgaagc caagctcgtg gaacaggcat tccggaaacg   1200

gaggcagagg ggtgtctcct gcttccgcac ccccttcggg cctctgtcct caaggagcgc   1260

tccagcttcg cccacacacc ccgggctgat gtcccctcgc tccggcggcc tgcagacccc   1320

agagtgcctg tctcgggagg gctcccccat tccacacgac cctgagtttg ggtccaagtt   1380

agcttctgtc ccagagtacc ggtattccca aagcgcaccc ggctcccccg tcagcgccca   1440

gccagtgatc atggccgtgc ctccccgacc gtccagcctc gtggccaagc ccgtggccta   1500

catgcccgcc tccatcgtaa cctcacagca gcccgcgggc cacgccatcc acgtcgtgca   1560

gcaggccccc accgtcacca tggtcagggt ggtcaccaca tctgccaact cggccaacgg   1620

atacatcctc accagccagg gcgcggcggg gggctcccat gatgcggcgg gcgcagccgt   1680

gctggacctg ggcagcgagg ccagaggcct ggaggagaaa cccaccattg cgtttgccac   1740

aatccccgcg gctggtggag tcatccagac ggtggccagc cagatggccc ccggggtccc   1800

cggacacacg gtcaccatcc tgcagcccgc cacacccgtg accctcgggc agcaccacct   1860

tccagtccgg gccgtgaccc agaacggaaa gcatgcggtt cccacgaaca gtttagccgg   1920

caacgcttac gccctcacca gccctttgca gctccttgcg acccaagcga gttcatccgc   1980

gccggtggtg gtcacccggg tgtgcgaggt ggggcccaag gagccagcag cagccgtcgc   2040

ggccacggcc accaccaccc cagccactgc caccaccgcc tctgcctccg cctcttccac   2100

tggagagccc gaggtcaaaa ggtcccgggt ggaggagccc agtggtgctg taaccacacc   2160

ggctggagtg atcgcagctg ccggccccca ggggccaggc accggggagt gaggtcacct   2220

gcaacgcggg ggagtgggac tcacccagcg gcgaccccga agctggaccc ggcagctcag   2280

gcggccgcac ccacagacgg aggagaacag cccgcggcgg cctgtgggca tcggcggcac   2340

ctggacacac ccagcccttt ccatttgatc gcctgccttc ccgtggttta agacaaaaac   2400

acataaacaa gttcagacaa ctgattgtat gattctggga attctttgct ttcctttcct   2460

tctccctcgg caccacctcc tctccccagg cctccctgtc gggcatgggg aggaggttgg   2520

agctcagcat cttgaggaat gtgtcaagac agcccctccg ctccgcgctg cacggccagc   2580

cgcctttgtc cgggaggaca gacagaaacg cagcaaggca cacaccaagg ctgccgggga   2640

ggcccgggca ccggacagat gcctgttggg aagccaggag ctgccgagcc acggaccacc   2700

taacagcctc tccgcccgga acgtgacata gagagtgttg gcattaactc ggggggtgtc   2760

cgatttcact tcagacccca agtttttctt tgtttgttta aacatggaat tcagacttca   2820

ttgtacacct gagacagaca caaaagggat catgtatttt tgaggatttt acctgttgac   2880

gtctgatgac cggccgtagg tccagggttc ccgctgggtt taatcccctc gaagagtaaa   2940

cctgccgctc tgtctgataa cttcaagtaa gagcagcggc ttcctgggtt ggcgttcgcg   3000

gtggaaggtt cctaggatga aaggtgagcc tggatccgcc ggccgcagac atcgcgctgc   3060

tggggacgat tggggccgct gctctgcaga ccagaccttc ccgaattatc cgtggctccg   3120

atgtcccggt gctgacggcc acatggggac ctaacagtgc caaacgccat ctgctccagc   3180

tgctttttca cccagttgca gagtcctcac cactcccaca ttgatctgct gttttcaatt   3240

ggaaccattt ctcctgcctg aaactccagg gcccctccct gggctgtccg tgagcaggag   3300

accccacccc agcagcagtg gtgagcaggc ctgtgcctcc acgcccagcc cccgccaacg   3360

cgactggttt tgtttgccac acggtgagaa ccggaggacg ggatgctcca gccagttggg   3420

tggttctggg gtccctgagg aagccccctc ctgcacttcc attaagacag ccagtggttc   3480

ctggatcttt gtcaccaagc agcgttgagc cagagctgtc taatgctgag cccagctcag   3540

gaaggagaga ggagtccttc agtgtgtctt ggagatgcga agtgcgtcct cgtaaaggtc   3600

agctgtcagt tttgctggcc gctccggcgc tggctctcct gtccgggacc acaacgagaa   3660

acagcgacag attcgacgca gagctccgga agtgcctgag gagcagtggt tcttggaaat   3720

cgcccgtcct ccgcatcaca gcctctcacc agcaaagcag cctctgccca ggccctggcg   3780

ggagagctgc agagggaccc aggtgcctgg agggcatttg agggaggtgg ctggacaggt   3840

gtctccctga agaagaaggg agaacacttt tcaaagtgat tccgaggcag tgcgggagga   3900

cacacgtgct gtgcagtgga gtggggtcgc ccgtggcccc catcagagtc cccgtccccc   3960

aggacaagtg cagaacctct gtgggccccc tccttccacc tagatagaga aaaccccttg   4020

ttcggtttcc ttcccgtgtc ccgttgtttt tctaagcccc ccgaattgag tcgtttctat   4080

ggcactaacc tttccatggg aaataagctc tttgtggaag tccgtacctg ttgccctggg   4140

tgaggtttca gagaaacggg ggcaggatga acacagccgg ctgtcctggg tgcagttacg   4200

tccgtggagg gtgagagatt gcgccccgtt ccacacttgt gtcgcctgct gttgtctgtg   4260

ggccttttct ttccgtggtg cctggtgtgt gcgtgcatgg cgtgagagaa cggggggtgg   4320

gggttggagg tggctccccg acaccggtgc ctgtgtggcc tgagccggcg ccctcccggg   4380

agcgcccgtc acggggggcc tctgtgatta cctgctgctg ctctctcccg cgtggtgact   4440

atatgtcctc agggctgcct gtggccaccc tgatgggaga cctctgtttg cttctgggcc   4500

actgcaggtt ggcctcctca atacaagctg atgtctgcag ggagcgccgc gtgctgggat   4560

tgcaccacgt gttggtcaca aatcgaggtc gccttttggc ctggtctgct caggctggcc   4620

ctgacccacg tggtttcctg gcttctgaga cgcagcgcat tcttcctgtt agcggtagcg   4680

ttctctgatt tcactgcttc attgccaagg gcgtggaaag ggggtggtgg atggagccgg   4740

gaggtggcga gcacaggacc ccggggctgc attctgccgt gtggggttct gcactgtcta   4800

gcttctgcgg ggactgcaaa gagggatgaa gggacgtggt cctaggggtc ggctcagact   4860

cggagcaggg cagggagagg agggcaagga gaggaggcct gggtcctgga tccactgctc   4920

tgggctcata accatgagat tttgaaagag tttttggtca tctgagcagg taccatgcct   4980

ggctcatgcc ggaacttgtc ttggaaccgg tagccagagg cccaggaagg gacagggccc   5040

aaaagggttg catgtcccgg ccacaaagcc ctccctgtgt gccctgagcc agcccagcaa   5100

gcgcctccca gccaggcgct ttcgcagaag caagagcaca ggccaggggg accgggagag   5160

cctcagcccc cagcctgggc ggcctgtgac cctgagccgt gtggagccag gacccaagaa   5220

ccttctctag gttctcaagg gtgagctgac ccgggcaatg tgcaggaatg tggggagcaa   5280

aagtagctga ttccagcccc gttctggggt cactggggag gcagaggctg agggcctgtt   5340

ctctggtcac cagggactgg gggcacggtc cacagcggat gagaacagca ggtcacagta   5400

gtggctttgg gaagggcccc tcctgctttg ccctgttcgg aaaggggctc cctcagagcc   5460

cctgggccca gtaacccgct tctgtctcct gactcctgct ggataaattg ccaggtttat   5520

caaatacaag aaaacacctg ctttggctag gaggtaagtc ccaaaaagaa cgtcttaagt   5580

agagcaaagg catccaccga ggccatttgg tggcccctgg gaagtgggga agcagggcct   5640

gagcgtcccc aggctgctag ggcagcagct ggctcagggc acactctctc gtgccagctt   5700

ctgccaccag cccagtgtcc acggagccgc ggggccagag gagctcaggg agacctggct   5760

gtctagggca tggtacccag tatcccggtg tgtgcccatc ctcagccact tgtgtctttc   5820

tttccatgtg ggagttctcc cggtgacacc tgccctccgt tgagggtgga atctgtcact   5880

catgcctttg agggacccag atggaccatc cctcttctgc ttgctttcta cattcctaaa   5940

aacctcaacg ttaatccctc accagtcggg ccgagtgtgg cctcatggtt ctgccgcggc   6000

ccagtcttct cccactggct tcacgctaga gggcgccatg cgctctgggt gaaatgagac   6060

gctggtgtgg ggtccccatg tagagaccct caggtcccta tccagagacc ctccaggcag   6120

tgctgggaag acactggtgg cggggaccat gaccaggcgg gtggagccat gtgtgtctca   6180

cacctgccgc ccctcacttt ccttcccgag gtctggtagg tcctctttgg gatttgctgt   6240

ttatttgtat ctcccttttc tttgatttaa gaacaatgcc aagtgaaaaa gctgggaatg   6300

aatttctgag ttgctgagtg ttccctgctc ctaggtacca cgctctgtgc ttctcaggca   6360

gggaggagat ggattcggtg gagttgggcc aggacggggg cttcaccctg ccccctccag   6420

actgccgaag cccccaagaa gttttgagcc cagctgggcc tcgcctcccc ggctcctggg   6480

tccattttct gtactggttt gagatcacag gcatcattca gcgaatgctc ttgtgtcctc   6540

tgcataaaga gggccctccc tggagcaccc ccggggagct gggactctcc agaaagcccc   6600

gggtgagggc tccgtcttga gagagagaga aatcccttct ttgggcgatt cagtgagttc   6660

aggaggagga ggaagctttt ccttggcttt gaaatcagtg tttttatgga gacaaagaac   6720

agacctcagt gggaaaaatg aaaacgtaat ggaacacggg gaggtgtcgg agaagaaagg   6780

attttcccct tcgctttcag agccggcggg agtgcaggtc tgttttgctt cagaagcctc   6840

acattctgct ttgcccttga gtgacttcat gcgggatgag gaactgttga cccctctaga   6900

gaggacaccc caagtccatc ctgggctcct cctcacccct ctgagaaagc ccccctaaaa   6960

aaaggcttca gagtcaccgg catgccgcct cacgttgcag gacggaatcg cgcgctcctc   7020

acgctggagt aagttacgaa acatgatcgt caggctcttt gcaaacgcag agccccagaa   7080

cgctggatgg aggcctcctc ggccctgcgg gcggcctggc tgcggtaggt ctgctgcaag   7140

gagccaccac ggggactgcg ccacactcct gatgaaaacg tgtttaccca cagcctcgcc   7200

tcgagcctcc ttgacaatac cgctgcttca aagcaatatt atttaatgag aatactttac   7260

attgctcaca tgtgctgcta tgaagacagg attagtctgt agacgggact cagctccaga   7320

ggttcctggg taatgtattg tggctcttgg aaatgagggt agaatttgaa atataacaaa   7380

tggtctctcg cccggttctg tcccttattt ttagattgtt ttcctgcatc ttacaatttc   7440

cttttctttt caaagttcct ttctccaggc ctgtttttca gtgctcagga cacggttttc   7500

atcacatact tactgttttt ttggttgggt tttgatacga aaagctgcta cgtttggtga   7560

ccagagggag ggtttggaat ctgtgctttg caggggatct cggtgggtac cgcggcccct   7620

cgcagggtgg cgagtggggt ccgtgcctcg agaagggggc ccttacccac accgtgcggc   7680

ttgaattctg tcggagttga atctgtggaa aggattgtcc cattagagct gctgcgtcct   7740

ttcctctgtc ctccctgtca cccaaacccc gaagtcacag ctgcttagaa gaatgggatt   7800

ttggggatac aaccacacac atttccctct ggactgaaat tttaaaaaca gacccatttc   7860

actgacttct tttttttttt tttttttttt ttttttttga gacggagtct cgctctgtcg   7920

cccaggctgg agtgcagtgg cgtgatctcg gctcactgca agctccgcct cccgggttca   7980

cgccattctc ctgcctcagc ctcccgagta gctgggacta caggcgcccg ctaccacgcc   8040

cggctaattt tttgtatttt tagtagagac ggggtttcac cgtgttagcc aggatggtct   8100

cgatctcctg acctcgtgat ccgcccgcct cggcctccca aagtgctggg attacaggcg   8160

tgagccaccg cgcccggccc actgacttct ttagggaaaa tagtttcagt cttgggttgt   8220

cttgtgagcc cacgggcatg ggaccctgtc tctgctgggc ttttccggcc ccgtcccagc   8280

tcctcctcag gcagaggctg cagccctcag ctctgctgct ggatggaaca tttcaacccc   8340

ctccgggaag gtgggcaggg tggagggccc agggctaggc ctgccatgca ccatgagcag   8400

gggtgctacc tgggtgtgtg aagttgggct ggcttttcct ggaggtgggt gagaaggctc   8460

tccgggcaaa tcagaaggcc acgagagaga gaggagcggg gagagtggtg aggaggattc   8520

gtctctgact gatgaacctc gccgtgcctg tctgtcacat ccaagtctgt gccagctgct   8580

gggaggtcag actcctgccc tgagaaacag cccagtcctt ggagaatgaa accctgaggg   8640

tcagtgagtg gaggccttcc ctcggggcca gccattcccg ggaggcctga gtgtgacctg   8700

gaagctctgt gggtcaccaa gactggcatt ttccttgtat ttttgtgcag ggctgaagtg   8760

agcgttcctc ctctgaattg gtgaggcttt ggaaattttt tgtttcttct actcatccta   8820

atggctggtt ttggctgccc ggagtatcag agaatatcac taagagggca gtcagtttat   8880

ttttaggcat ctttctttct gtccagggag aaacccctcg gaagaatctt agtcactctt   8940

tgcacctgcc ctgtcattct cgccatgggg aaaatgcgtt gaaaagaaaa ataccggggc   9000

cagggagaag ccgtgaatgt atttatttgc tttggtgaag ctgctgaaca ctggctgcgg   9060

agggcccccc gcccccatcc cgcttcaggc cccagtgacc cagttgcgtc ttaagttcca   9120

tcgtccagat ttcaggccac cagaggctgc caaaggtgac tgaagcggtc tccaagtcac   9180

tctgtcacca cttttttttt ttttgagatg gagtctcgct ctatcgccca ggctggagtg   9240

cagtggccca atctcggctc actgcaacct ccgcctccca ggttcgagcg aattctcctg   9300

cctcaacctc ccaagtagct gggattacag gcacctgcca ccacacccgg ctaatttttg   9360

tatttctaat agagatgaga gtgttaccat gttggtcagg ctggtcttga actcctgacc   9420

tcaggtgatc tgcccacctc aacctcccaa agtgctggga ttataggcat gagccaccgc   9480

gcctggcctc tgtcactttt tttgctcctt acccagtttt tgttttttgt tgttttgttt   9540

tgttttagcg tgatactaca atggaaagac tcctagttgg ttattcttta tctcggattc   9600

ttttttctgg aattgtttgc tcatttgagt ggttggtggt ttgccctgtg tcagacacgg   9660

tgaaaagagt gcaggaaagc tggggccagg ggaagcgaag tggcttcaat ccgggctgac   9720

agccaagaag agttttcctc ccttcggtga cagggcctgc ccctccgagt ctagaggtaa   9780

aagcagcttc tagaactggc ccctaagtct ccaaatgtgt tggctaagct gaaatgagag   9840

actctgaatt agagtttttg tttgtttgtt tgttctctgc atgaagttca caggcctgta   9900

tggatgttaa attgtgtcta tagcctctaa atctccaggt taactggtcc agattttttt   9960

tttttaatca gtaacaatgg gaatttaaaa tcaaatattt ggccaggtgc ggtggctcat  10020

gcccgtaatc ccagcacttt gggaggccga ggcaggcgca tcacctgagg agtttgagac  10080

cagcctgacc aacatggtga aatcctgtct ctactaaaaa tacaaaaaat tagccaggcg  10140

tggtggcgtg tgcctgtaat cccagctacc agggaggctg aggcatgaga atcgcttgaa  10200

cctgggagat ggaggttgca gtgagccgag atcatgccac tgcactccag cctgggcaac  10260

agagggagac tctgtctcaa aaataataat caaatcaagt attttaagtt tggctcttct  10320

ttttttcaag aaaggctttt tggataccta gaataccttc atgtatgtgg cttgatttct  10380

gtttcaggaa aaggggggcg ggaggagaga caacagccgt gttccagagt ctgtcctgag  10440

atgtcgctga gtccagacac ttgggctgca cgtgccctgc agatgacaaa ggccggcagc  10500

tcagcacacg tgcaggaggg gttaaagcca atattgagtt tttgttcttg ttgttttaat  10560

ctgaacgatt attctcctgt aaaaataatt tgggaggggc gggtgttgtt cggtgtgtgt  10620

gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt attttttttt ttacagtggc gcctgtctaa  10680

agtatttttc acaacatgtt tgataatcag tgctttaaaa agcagcagtg tcctatgaag  10740

tggaaatgtc agttctagag cattggatgt gaagttctgg tcatgtcacc ttgcgtgtct  10800

caccctggag gagtgaaggt gggcgcccgg cgggggggtg tggctgcacc ccagcaccgg  10860

gagggggcac gcacgacacc agaggaaggg acagccccac ccatgtcaac agcaggcaac  10920

ctgtgttttc atttcaagtg ggatacagta tttttttaat aaggagccat actttttttt  10980

aagagtttga gatctgaatg tgatttctaa ttgtatcaga cgttaatgtt ttaaagctat  11040

aacaaagttt aaaatttcta ctttttgttt ttcatttatt ttaactgttc ttttatctat  11100

taaattgttg tatgtggatg gggaagtttt gtttctcctc ttagcatttg tttctataac  11160

cagaaataaa attctatatt aaagaaatga ccctgcggct ccggtgtggt ccttctgcgc  11220

aggtggctac tgaaggtggc ggacggacag acggcctgga cacacagaca ccaggcccct  11280

ggacacatag gctcccgacc ccctggatac acaaacacct gaccccctgg acacacaggc  11340

tcctgacccc cggacacaca gacccctgag cccctagaca tacaggcacc tggccccctg  11400

gacacagagg ctcccgaccc cctagacata caggctcccg gccccctgga cacacaggcc  11460

cctgaccccc tggacacaca ggcccctgac cccctggaca cacagacccc tgacccctgg  11520

acacacagac ccctgagccc ctggacatac aggctcccgg                        11560


<210>  3511
<211>  733
<212>  PRT
<213>  Homo sapiens

<400>  3511

Met Ala Glu Val Gly Glu Asp Ser Gly Ala Arg Ala Leu Leu Ala Leu 
1               5                   10                  15


Arg Ser Ala Pro Cys Ser Pro Val Leu Cys Ala Ala Ala Ala Ala Ala 
            20                  25                  30


Ala Phe Pro Ala Ala Ala Pro Pro Pro Ala Pro Ala Gln Pro Gln Pro 
        35                  40                  45


Pro Pro Gly Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Pro Gly Ala 
    50                  55                  60


Ile Ala Gly Ala Gly Ser Ser Gly Gly Ser Ser Gly Val Ser Gly Asp 
65                  70                  75                  80


Ser Ala Val Ala Gly Ala Ala Pro Ala Leu Val Ala Ala Ala Ala Ala 
                85                  90                  95


Ser Val Arg Gln Ser Pro Gly Pro Ala Leu Ala Arg Leu Glu Gly Arg 
            100                 105                 110


Glu Phe Glu Phe Leu Met Arg Gln Pro Ser Val Thr Ile Gly Arg Asn 
        115                 120                 125


Ser Ser Gln Gly Ser Val Asp Leu Ser Met Gly Leu Ser Ser Phe Ile 
    130                 135                 140


Ser Arg Arg His Leu Gln Leu Ser Phe Gln Glu Pro His Phe Tyr Leu 
145                 150                 155                 160


Arg Cys Leu Gly Lys Asn Gly Val Phe Val Asp Gly Ala Phe Gln Arg 
                165                 170                 175


Arg Gly Ala Pro Ala Leu Gln Leu Pro Lys Gln Cys Thr Phe Arg Phe 
            180                 185                 190


Pro Ser Thr Ala Ile Lys Ile Gln Phe Thr Ser Leu Tyr His Lys Glu 
        195                 200                 205


Glu Ala Pro Ala Ser Pro Leu Arg Pro Leu Tyr Pro Gln Ile Ser Pro 
    210                 215                 220


Leu Lys Ile His Ile Pro Glu Pro Asp Leu Arg Ser Met Val Ser Pro 
225                 230                 235                 240


Val Pro Ser Pro Thr Gly Thr Ile Ser Val Pro Asn Ser Cys Pro Ala 
                245                 250                 255


Ser Pro Arg Gly Ala Gly Ser Ser Ser Tyr Arg Phe Val Gln Asn Val 
            260                 265                 270


Thr Ser Asp Leu Gln Leu Ala Ala Glu Phe Ala Ala Lys Ala Ala Ser 
        275                 280                 285


Glu Gln Gln Ala Asp Thr Ser Gly Gly Asp Ser Pro Lys Asp Glu Ser 
    290                 295                 300


Lys Pro Pro Phe Ser Tyr Ala Gln Leu Ile Val Gln Ala Ile Ser Ser 
305                 310                 315                 320


Ala Gln Asp Arg Gln Leu Thr Leu Ser Gly Ile Tyr Ala His Ile Thr 
                325                 330                 335


Lys His Tyr Pro Tyr Tyr Arg Thr Ala Asp Lys Gly Trp Gln Asn Ser 
            340                 345                 350


Ile Arg His Asn Leu Ser Leu Asn Arg Tyr Phe Ile Lys Val Pro Arg 
        355                 360                 365


Ser Gln Glu Glu Pro Gly Lys Gly Ser Phe Trp Arg Ile Asp Pro Ala 
    370                 375                 380


Ser Glu Ala Lys Leu Val Glu Gln Ala Phe Arg Lys Arg Arg Gln Arg 
385                 390                 395                 400


Gly Val Ser Cys Phe Arg Thr Pro Phe Gly Pro Leu Ser Ser Arg Ser 
                405                 410                 415


Ala Pro Ala Ser Pro Thr His Pro Gly Leu Met Ser Pro Arg Ser Gly 
            420                 425                 430


Gly Leu Gln Thr Pro Glu Cys Leu Ser Arg Glu Gly Ser Pro Ile Pro 
        435                 440                 445


His Asp Pro Glu Phe Gly Ser Lys Leu Ala Ser Val Pro Glu Tyr Arg 
    450                 455                 460


Tyr Ser Gln Ser Ala Pro Gly Ser Pro Val Ser Ala Gln Pro Val Ile 
465                 470                 475                 480


Met Ala Val Pro Pro Arg Pro Ser Ser Leu Val Ala Lys Pro Val Ala 
                485                 490                 495


Tyr Met Pro Ala Ser Ile Val Thr Ser Gln Gln Pro Ala Gly His Ala 
            500                 505                 510


Ile His Val Val Gln Gln Ala Pro Thr Val Thr Met Val Arg Val Val 
        515                 520                 525


Thr Thr Ser Ala Asn Ser Ala Asn Gly Tyr Ile Leu Thr Ser Gln Gly 
    530                 535                 540


Ala Ala Gly Gly Ser His Asp Ala Ala Gly Ala Ala Val Leu Asp Leu 
545                 550                 555                 560


Gly Ser Glu Ala Arg Gly Leu Glu Glu Lys Pro Thr Ile Ala Phe Ala 
                565                 570                 575


Thr Ile Pro Ala Ala Gly Gly Val Ile Gln Thr Val Ala Ser Gln Met 
            580                 585                 590


Ala Pro Gly Val Pro Gly His Thr Val Thr Ile Leu Gln Pro Ala Thr 
        595                 600                 605


Pro Val Thr Leu Gly Gln His His Leu Pro Val Arg Ala Val Thr Gln 
    610                 615                 620


Asn Gly Lys His Ala Val Pro Thr Asn Ser Leu Ala Gly Asn Ala Tyr 
625                 630                 635                 640


Ala Leu Thr Ser Pro Leu Gln Leu Leu Ala Thr Gln Ala Ser Ser Ser 
                645                 650                 655


Ala Pro Val Val Val Thr Arg Val Cys Glu Val Gly Pro Lys Glu Pro 
            660                 665                 670


Ala Ala Ala Val Ala Ala Thr Ala Thr Thr Thr Pro Ala Thr Ala Thr 
        675                 680                 685


Thr Ala Ser Ala Ser Ala Ser Ser Thr Gly Glu Pro Glu Val Lys Arg 
    690                 695                 700


Ser Arg Val Glu Glu Pro Ser Gly Ala Val Thr Thr Pro Ala Gly Val 
705                 710                 715                 720


Ile Ala Ala Ala Gly Pro Gln Gly Pro Gly Thr Gly Glu 
                725                 730


<210>  3512
<211>  342
<212>  DNA
<213>  Homo sapiens

<400>  3512
ctgctccttc agcacagccc acactcctag ggacctcgca cttcccggag caacaccctc     60

ccactgtcct ggctgcaggg cgggcgcgcc gcgtctctgg aaggccccgt ccacgaagac    120

gccgttcttg ccgaggcagc gcaggtagaa gtgcggctcc tggaagctga gctgcaggtg    180

gcgccgcgag atgaagctgg acaggcccat gctcaagtcc accgagccct gcgacgagtt    240

gcggccgatg gtgacgctgg gctggcgcat gaggaactcg aactcgcggc cctccagccg    300

cgccagcgcc ggccccgggc tctgccgtac cgaggcggcc gc                       342


<210>  3513
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  3513

Met Lys Leu Asp Arg Pro Met Leu Lys Ser Thr Glu Pro Cys Asp Glu 
1               5                   10                  15


Leu Arg Pro Met Val Thr Leu Gly Trp Arg Met Arg Asn Ser Asn Ser 
            20                  25                  30


Arg Pro Ser Ser Arg Ala Ser Ala Gly Pro Gly Leu Cys Arg Thr Glu 
        35                  40                  45


Ala 



<210>  3514
<211>  503
<212>  DNA
<213>  Homo sapiens

<400>  3514
tagtaaatgt ggatggcttg aataattaca atgagaacaa gacttctgtt tgtggtaact     60

ttgagtggta agattcatat gggtgtcttt ttttctttat acttttctgt gttttccatg    120

ttttctgaat gctgggatta caggcatgag ccaccgcacc cggccagcat tcattgttta    180

gttcacgcga gttttcaggt ttgcgttagt ggtgtcgtga catcttcttc atgatcctgt    240

ttgtgttttc cacttctctg gaaagaccgc ttcataggtt ggtgccatca gacatgcgta    300

accctagtgg gtgtagcccc ccatcctgga cggggccttg acggggcctc tggcctcctc    360

ccctgccttc ctcttctcag ctctgaccag aggggatgga agcttgtgtc cctctgggtg    420

acagacccag cctgcccgcc ctacccagct cgggttctgg gttcctttgt cctcgtcccc    480

agggctgcgt gtcctgctcg tcc                                            503


<210>  3515
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  3515

Met Arg Thr Arg Leu Leu Phe Val Val Thr Leu Ser Gly Lys Ile His 
1               5                   10                  15


Met Gly Val Phe Phe Ser Leu Tyr Phe Ser Val Phe Ser Met Phe Ser 
            20                  25                  30


Glu Cys Trp Asp Tyr Arg His Glu Pro Pro His Pro Ala Ser Ile His 
        35                  40                  45


Cys Leu Val His Ala Ser Phe Gln Val Cys Val Ser Gly Val Val Thr 
    50                  55                  60


Ser Ser Ser 
65


<210>  3516
<211>  1928
<212>  DNA
<213>  Homo sapiens

<400>  3516
ttcttagaag tggaaatgtg tgtagcaata ggaacggttc ctaaggccaa gaataaatgg     60

attgcggttg tgggtctttt ggtagcacta agctttctgt tgcagtgtgt gagaggaccc    120

ggggagagcc caatcttcga agggacagat gaggggtatg acctggggag cccacaaccg    180

cctttgcttt tcgcagatgc tgggaacgca gctctgctgc cggcggggtg gacagaccct    240

cccccagcca ttgctgccca cctgctgcgt cagggcctcc cctgcccagc tcagtcttgg    300

ccaagcccag tctggaggag catgcaccgc ctgtgagcgg tctgggcagc gcttcccagg    360

ttgcccatca gatgagcccg tcccaggtgt cgaggaggag atctcctgag cggcagtctc    420

ggaaatcctt ccccgtggaa ggacacgtta acctctcgtg cttcccattt caaaattctg    480

tttccaacac gatttgatga aagattgaaa tatctgaaaa ttcatttcga gcacagggtc    540

tggcattgtg attctcaggt gaactgggcg tatggttgag gtaggacttc aaaaaagtgt    600

tcgaacgtca tttgcagcat ttaaactgag ctccaaatga cgttcaaaca cccctctcgg    660

gtagagtttt catggtggaa cggttgcgcc caccaaacag aagcttatgt ttttggcaca    720

gaaggcctgg gccattttca tggacacctg gctggacctc ggtggaagtg aactccgtag    780

gttgttgcgt tcactgcagc acctcacatg ataccgtccc ctctcatgga acggagcctc    840

ccccatgcag cccccactca aatggagttt taaaggctgg gttcaggtta cgggggcgtt    900

tctcaccgtc tgaatgcgga ggacagagac gagctccagg gagcgtgggc gggtgacggc    960

gctgagatgc gtgatgtctc ggaaacgtcc tcgcatccct cagcgcgggc gctgactgcc   1020

gcggcccttg cctgtcttcc aggagcgctc cagcttcgcc cacacacccc gggctgatgt   1080

cccctcgctc cggcggcctg cagaccccag agtgcctgtc tcgggagggc tcccccattc   1140

cacacgaccc tgagtttggg tccaagttag cttctgtccc agagtaccgg tattcccaaa   1200

gcgcacccgg ctcccccgtc agcgcccagc cagtgatcat ggccgtgcct ccccgaccgt   1260

ccagcctcgt ggccaagccc gtggcctaca tgcccgcctc catcgtaacc tcacagcagc   1320

ccgcgggcca cgccatccac gtcgtgcagc aggcccccac cgtcaccatg gtcagggtgg   1380

tcaccacatc tgccaactcg gccaacggat acatcctcac cagccagggc gcggcggggg   1440

gctcccatga tgcggcgggc gcagccgtgc tggacctggg cagcgaggcc agaggtaatg   1500

cagccgcggc tggcagcctt cgcaggaccc tttgtggtgg tcccggccgg caagtcccca   1560

aggcagcgcc attggcctgg gcctggggct tgaggaggat gattctctgc ttctgcctct   1620

cgctgccttg tccctttaaa tcagcatgag ctgggcaggt ggctcatgct tataatccca   1680

gtgctttggg aggccaaagc gggtggatta cttgaggtcc ggagttcgag gtcagcctgg   1740

ccaacatact gaaaccccgt ctctactgaa aatacaaaaa ttagccaggc atgatgatgc   1800

gctcctgtag tcccagctac tcaggaggct gagggaggag aatcgcttga agcctggagg   1860

cagaggttgc agtgagctag actgcgccac tgcactccag cctgggcgac agagcaaaac   1920

cctgtctc                                                            1928


<210>  3517
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  3517

Met Ser Pro Arg Ser Gly Gly Leu Gln Thr Pro Glu Cys Leu Ser Arg 
1               5                   10                  15


Glu Gly Ser Pro Ile Pro His Asp Pro Glu Phe Gly Ser Lys Leu Ala 
            20                  25                  30


Ser Val Pro Glu Tyr Arg Tyr Ser Gln Ser Ala Pro Gly Ser Pro Val 
        35                  40                  45


Ser Ala Gln Pro Val Ile Met Ala Val Pro Pro Arg Pro Ser Ser Leu 
    50                  55                  60


Val Ala Lys Pro Val Ala Tyr Met Pro Ala Ser Ile Val Thr Ser Gln 
65                  70                  75                  80


Gln Pro Ala Gly His Ala Ile His Val Val Gln Gln Ala Pro Thr Val 
                85                  90                  95


Thr Met Val Arg Val Val Thr Thr Ser Ala Asn Ser Ala Asn Gly Tyr 
            100                 105                 110


Ile Leu Thr Ser Gln Gly Ala Ala Gly Gly Ser His Asp Ala Ala Gly 
        115                 120                 125


Ala Ala Val Leu Asp Leu Gly Ser Glu Ala Arg Gly Asn Ala Ala Ala 
    130                 135                 140


Ala Gly Ser Leu Arg Arg Thr Leu Cys Gly Gly Pro Gly Arg Gln Val 
145                 150                 155                 160


Pro Lys Ala Ala Pro Leu Ala Trp Ala Trp Gly Leu Arg Arg Met Ile 
                165                 170                 175


Leu Cys Phe Cys Leu Ser Leu Pro Cys Pro Phe Lys Ser Ala 
            180                 185                 190


<210>  3518
<211>  486
<212>  DNA
<213>  Homo sapiens

<400>  3518
agggagaaca cttttcaaag tgattccgag gcagtgcggg aggacacacg tgctgtgcag     60

tggagtgggg tcgcccgtgg cccccatcag agtccccgtc ccccaggaca agtgcagaac    120

ctccggcggg ggggtgtggc tgcaccccag caccgggagg gggcacgcac gacaccagag    180

gaagggacag ccccacccat gtcaacagca ggcaacctgt gttttcattt caagtgggat    240

acagtatttt tttaataagg agccatactt ttttttaaga gtttgagatc tgaatgtgat    300

ttctaattgt atcagacgtt aatgttttaa agctataaca aagtttaaaa tttctacttt    360

ttgtttttca tttattttaa ctgttctttt atctattaaa ttgttgtatg tggatgggga    420

agttttgttt ctcctcttag catttgtttc tataaccaga aataaaattc tatattaaag    480

aaatga                                                               486


<210>  3519
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  3519

Gly Arg Thr Leu Phe Lys Val Ile Pro Arg Gln Cys Gly Arg Thr His 
1               5                   10                  15


Val Leu Cys Ser Gly Val Gly Ser Pro Val Ala Pro Ile Arg Val Pro 
            20                  25                  30


Val Pro Gln Asp Lys Cys Arg Thr Ser Gly Gly Gly Val Trp Leu His 
        35                  40                  45


Pro Ser Thr Gly Arg Gly His Ala Arg His Gln Arg Lys Gly Gln Pro 
    50                  55                  60


His Pro Cys Gln Gln Gln Ala Thr Cys Val Phe Ile Ser Ser Gly Ile 
65                  70                  75                  80


Gln Tyr Phe Phe Asn Lys Glu Pro Tyr Phe Phe Leu Arg Val 
                85                  90


<210>  3520
<211>  676
<212>  DNA
<213>  Homo sapiens

<400>  3520
ggaactttga aaagaaaagg aaattgtaag atgcaggaaa acaatctaaa aataagggac     60

agaaccgggc gagagaccat ttgttatatt tcaaattcta ccctcatttc caagagccac    120

aatacattac ccaggaacct ctggagctga gtcccgtcta cagactaatc ctgtcttcat    180

agcagcacat gtgagcaatg taaagtattc tcattaaata atattgcttt gaagcagcgg    240

tattgtcaag gaggctcgag gcgaggctgt gggtaaacac gttttcatca ggacagtgaa    300

atcagagaac gctaccgcta acaggaagaa tgcgctgcgt ctcagaagcc aggaaaccac    360

gtgggtcagg gccagcctga gcagaccagg ccaaaaggcg acctcgattt gtgaccaaca    420

cgtggtgcaa tcccagcacg cggcgctccc tgcagacatc agcttgtatt gaggaggcca    480

acctgcagtg gcccagaagc aaacagaggt ctcccatcag ggtggccaca ggcagccctg    540

aggacatata gtcaccacgc gggagagagc agcagcaggt aatcacagag gccccccgtg    600

acgggcgctc ccgggagggc gccggctcag gccacacagg caccggtgtc ggggagccac    660

ctccaacccc cacccc                                                    676


<210>  3521
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  3521

Met Gln Glu Asn Asn Leu Lys Ile Arg Asp Arg Thr Gly Arg Glu Thr 
1               5                   10                  15


Ile Cys Tyr Ile Ser Asn Ser Thr Leu Ile Ser Lys Ser His Asn Thr 
            20                  25                  30


Leu Pro Arg Asn Leu Trp Ser 
        35


<210>  3522
<211>  2428
<212>  DNA
<213>  Homo sapiens

<400>  3522
gcgcattctt cctgttagcg gtagcgttct ctgatttcac tgcttcattg ccaagggcgt     60

ggaaaggggg tggtggatgg agccgggagg tggcgagcac aggacccaag aaccttctct    120

aggttctcaa gggtgagctg acccgggcaa tgtgcaggaa tgtggggagc aaaagtagct    180

gattccagcc ccgttctggg gtcactgggg aggcagaggc tgagggcctg ttctctggtc    240

accagggact gggggcacgg tccacagcgg atgagaacag caggtcacag tagtggcttt    300

gggaagggcc cctcctgctt tgccctgttc ggaaaggggc tccctcagag cccctgggcc    360

cagtaacccg cttctgtctc ctgactcctg ctggataaat tgccaggttt atcaaataca    420

agaaaacacc tgctttggct aggaggtaag tcccaaaaag aacgtcttaa gtagagcaaa    480

ggcatccacc gaggccattt ggtggcccct gggaagtggg gaagcagggc ctgagcgtcc    540

ccaggctgct agggcagcag ctggctcagg gcacactctc tcgtgccagc ttctgccacc    600

agcccagtgt ccacggagcc gcggggccag aggagctcag ggagacctgg ctgtctaggg    660

catggtaccc agtatcccgg tgtgtgccca tcctcagcca cttgtgtctt tctttccatg    720

tgggagttct cccggtgaca cctgccctcc gttgagggtg gaatctgtca ctcatgcctt    780

tgagggaccc agatggacca tccctcttct gcttgctttc tacattccta aaaacctcaa    840

cgttaatccc tcaccagtcg ggccgagtgt ggcctcatgg ttctgccgcg gcccagtctt    900

ctcccactgg cttcacgcta gagggcgcca tgcgctctgg gtgaaatgag acgctggtgt    960

ggggtcccca tgtagagacc ctcaggtccc tatccagaga ccctccaggc agtgctggga   1020

agacactggt ggcggggacc atgaccaggc gggtggagcc atgtgtgtct cacacctgcc   1080

gcccctcact ttccttcccg aggtctggta ggtcctcttt gggatttgct gtttatttgt   1140

atctcccttt tctttgattt aagaacaatg ccaagtgaaa aagctgggaa tgaatttctg   1200

agttgctgag tgttccctgc tcctaggtac cacgctctgt gcttctcagg cagggaggag   1260

atggattcgg tggagttggg ccaggacggg ggcttcaccc tgccccctcc agactgccga   1320

agcccccaag aagttttgag cccagctggg cctcgcctcc ccggctcctg ggtccatttt   1380

ctgtactggt ttgagatcac aggcatcatt cagcgaatgc tcttgtgtcc tctgcataaa   1440

gagggccctc cctggagcac ccccggggag ctgggactct ccagaaagcc ccgggtgagg   1500

gctccgtctt gagagagaga gaaatccctt ctttgggcga ttcagtgagt tcaggaggag   1560

gaggaagctt ttccttggct ttgaaatcag tgtttttatg gagacaaaga acagacctca   1620

gtgggaaaaa tgaaaacgta atggaacacg gggaggtgtc ggagaagaaa ggattttccc   1680

cttcgctttc agagccggcg ggagtgcagg tctgttttgc ttcagaagcc tcacattctg   1740

ctttgccctt gagtgacttc atgcgggatg aggaactgtt gacccctcta gagaggacac   1800

cccaagtcca tcctgggctc ctcctcaccc ctctgagaaa gcccccctaa aaaaaggctt   1860

cagagtcacc ggcatgccgc ctcacgttgc aggacggaat cgcgcgctcc tcacgctgga   1920

gtaagttacg aaacatgatc gtcaggctct ttgcaaacgc agagccccag aacgctggat   1980

ggaggcctcc tcggccctgc gggcggcctg gctgcggtag gtctgctgca aggagccacc   2040

acggggactg cgccacactc ctgatgaaaa cgtgtttacc cacagcctcg cctcgagcct   2100

ccttgacaat accgctgctt caaagcaata ttatttaatg agaatacttt acattgctca   2160

catgtgctgc tatgaagaca ggattagtct gtagacggga ctcagctcca gaggttcctg   2220

ggtaatgtat tgtggctctt ggaaatgagg gtagaatttg aaatataaca aatggtctct   2280

cgcccggttc tgtcccttat ttttagattg ttttcctgca tcttacaatt tccttttctt   2340

ttcaaagttc ctttctccag gcctgttttt cagtgctcag gacacggttt tcatcacata   2400

cttactgttt ttttggttgg gttttgat                                      2428


<210>  3523
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  3523

Met Val Pro Ser Ile Pro Val Cys Ala His Pro Gln Pro Leu Val Ser 
1               5                   10                  15


Phe Phe Pro Cys Gly Ser Ser Pro Gly Asp Thr Cys Pro Pro Leu Arg 
            20                  25                  30


Val Glu Ser Val Thr His Ala Phe Glu Gly Pro Arg Trp Thr Ile Pro 
        35                  40                  45


Leu Leu Leu Ala Phe Tyr Ile Pro Lys Asn Leu Asn Val Asn Pro Ser 
    50                  55                  60


Pro Val Gly Pro Ser Val Ala Ser Trp Phe Cys Arg Gly Pro Val Phe 
65                  70                  75                  80


Ser His Trp Leu His Ala Arg Gly Arg His Ala Leu Trp Val Lys 
                85                  90                  95


<210>  3524
<211>  3079
<212>  DNA
<213>  Homo sapiens

<400>  3524
aatcagtgtt tttatggaga caaagaacag acctcagtgg gaaaaatgaa aacgtaatgg     60

aacacgggga ggtgtcggag aagaaaggat tttccccttc gctttcagag ccggcgggag    120

tgcaggtctg ttttgcttca gaagcctcac attctgcttt gcccttgagt gacttcatgc    180

gggatgagga actgttgacc cctctagaga ggacacccca agtccatcct gggctcctcc    240

tcacccctct gagaaagccc ccctaaaaaa aggcttcaga gtcaccggca tgccgcctca    300

cgttgcagga cggaatcgcg cgctcctcac gctggagtaa gttacgaaac atgatcgtca    360

ggctctttgc aaacgcagag ccccagaacg ctggatggag gcctcctcgg ccctgcgggc    420

ggcctggctg cggtaggtct gctgcaagga gccaccacgg ggactgcgcc acactcctga    480

tgaaaacgtg tttacccaca gcctcgcctc gagcctcctt gacaataccg ctgcttcaaa    540

gcaatattat ttaatgagaa tactttacat tgctcacatg tgctgctatg aagacaggat    600

tagtctgtag acgggactca gctccagagg ttcctgggta atgtattgtg gctcttggaa    660

atgagggtag aatttgaaat ataacaaatg gtctctcgcc cggttctgtc ccttattttt    720

agattgtttt cctgcatctt acaatttcct tttcttttca aagttccttt ctccaggcct    780

gtttttcagt gctcaggaca cggttttcat cacatactta ctgttttttt ggttgggttt    840

tgatacgaaa agctgctacg tttggtgacc agagggaggg tttggaatct gtgctttgca    900

ggggatctcg gtgggtaccg cggcccctcg cagggtggcg agtggggtcc gtgcctcgag    960

aagggggccc ttacccacac cgtgcggctt gaattctgtc ggagttgaat ctgtggaaag   1020

gattgtccca ttagagctgc tgcgtccttt cctctgtcct ccctgtcacc caaaccccga   1080

agtcacagct gcttagaaga atgggatttt ggggatacaa ccacacacat ttccctctgg   1140

actgaaattt taaaaacaga cccatttcat gacttcttta gggaaaatag tttcagtctt   1200

gggttgtctt gtgagcccac gggcatggga ccctgtctct gctgggcttt tccggccccg   1260

tcccagctcc tcctcaggca gaggctgcag ccctcagctc tgctgctgga tggaacattt   1320

caaccccctc cgggaaggtg ggcagggtgg agggcccagg gctaggcctg ccatgcacca   1380

tgagcagggg tgctacctgg gtgtgtgaag ttgggctggc ttttcctgga ggtgggtgag   1440

aaggctctcc gggcaaatca gaaggccacg agagagagag gagcggggag agtggtgagg   1500

aggattcgtc tctgactgat gaacctcgcc gtgcctgtct gtcacatcca agtctgtgcc   1560

agctgctggg aggtcagact cctgccctga gaaacagccc agtccttgga gaatgaaacc   1620

ctgagggtca gtgagtggag gccttccctc ggggccagcc attcccggga ggcctgagtg   1680

tgacctggaa gctctgtggg tcaccaagac tggcattttc cttgtatttt tgtgcagggc   1740

tgaagtgagc gttcctcctc tgaattggtg aggctttgga aattttttgt ttcttctact   1800

catcctaatg gctggttttg gctgcccgga gtatcagaga atatcactaa gagggcagtc   1860

agtttatttt taggcatctt tctttctgtc cagggagaaa cccctcggaa gaatcttagt   1920

cactctttgc acctgccctg tcattctcgc catggggaaa atgcgttgaa aagaaaaata   1980

ccggggccag ggagaagccg tgaatgtatt tatttgcttt ggtgaagctg ctgaacactg   2040

gctgcggagg gccccccgcc cccatcccgc ttcaggcccc agtgacccag ttgcgtctta   2100

agttccatcg tccagatttc aggccaccag aggctgccaa aggtgactga agcggtctcc   2160

aagtcactct gtcaccatca aatcaagtat tttaagtttg gctcttcttt ttttcaagaa   2220

aggctttttg gatacctaga ataccttcat gtatgtggct tgatttctgt ttcaggaaaa   2280

ggggggcggg aggagagaca acagccgtgt tccagagtct gtcctgagat gtcgctgagt   2340

ccagacactt gggctgcacg tgccctgcag atgacaaagg ccggcagctc agcacacgtg   2400

caggaggggt taaagccaat attgagtttt tgttcttgtt gttttaatct gaacgattat   2460

tctcctgtaa aaataatttg ggaggggcgg gtgttgttcg gtgtgtgtgt gtgtgtgtgt   2520

gtgtgtgtgt gtgtgtgtat tttttttttt acagtggcgc ctgtctaaag tatttttcac   2580

aacatgtttg ataatcagtg ctttaaaaag cagcagtgtc ctatgaagtg gaaatgtcag   2640

ttctagagca ttggatgtga agttctggtc atgtcacctt gcgtgtctca ccctggagga   2700

gtgaaggtgg gcgcccggcg ggggggtgtg gctgcacccc agcaccggga gggggcacgc   2760

acgacaccag aggaagggac agccccaccc atgtcaacag caggcaacct gtgttttcat   2820

ttcaagtggg atacagtatt tttttaataa ggagccatac ttttttttaa gagtttgaga   2880

tctgaatgtg atttctaatt gtatcagacg ttaatgtttt aaagctataa caaagtttaa   2940

aatttctact ttttgttttt catttatttt aactgttctt ttatctatta aattgttgta   3000

tgtggatggg gaagttttgt ttctcctctt agcatttgtt tctataacca gaaataaaat   3060

tctatattaa agaaatgac                                                3079


<210>  3525
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  3525

Met Thr Ser Leu Gly Lys Ile Val Ser Val Leu Gly Cys Leu Val Ser 
1               5                   10                  15


Pro Arg Ala Trp Asp Pro Val Ser Ala Gly Leu Phe Arg Pro Arg Pro 
            20                  25                  30


Ser Ser Ser Ser Gly Arg Gly Cys Ser Pro Gln Leu Cys Cys Trp Met 
        35                  40                  45


Glu His Phe Asn Pro Leu Arg Glu Gly Gly Gln Gly Gly Gly Pro Arg 
    50                  55                  60


Ala Arg Pro Ala Met His His Glu Gln Gly Cys Tyr Leu Gly Val 
65                  70                  75


<210>  3526
<211>  3448
<212>  DNA
<213>  Homo sapiens

<400>  3526
aatcagtgtt tttatggaga caaagaacag acctcagtgg gaaaaatgaa aacgtaatgg     60

aacacgggga ggtgtcggag aagaaaggat tttccccttc gctttcagag ccggcgggag    120

tgcaggtctg ttttgcttca gaagcctcac attctgcttt gcccttgagt gacttcatgc    180

gggatgagga actgttgacc cctctagaga ggacacccca agtccatcct gggctcctcc    240

tcacccctct gagaaagccc ccctaaaaaa aggcttcaga gtcaccggca tgccgcctca    300

cgttgcagga cggaatcgcg cgctcctcac gctggagtaa gttacgaaac atgatcgtca    360

ggctctttgc aaacgcagag ccccagaacg ctggatggag gcctcctcgg ccctgcgggc    420

ggcctggctg cggtaggtct gctgcaagga gccaccacgg ggactgcgcc acactcctga    480

tgaaaacgtg tttacccaca gcctcgcctc gagcctcctt gacaataccg ctgcttcaaa    540

gcaatattat ttaatgagaa tactttacat tgctcacatg tgctgctatg aagacaggat    600

tagtctgtag acgggactca gctccagagg ttcctgggta atgtattgtg gctcttggaa    660

atgagggtag aatttgaaat ataacaaatg gtctctcgcc cggttctgtc ccttattttt    720

agattgtttt cctgcatctt acaatttcct tttcttttca aagttccttt ctccaggcct    780

gtttttcagt gctcaggaca cggttttcat cacatactta ctgttttttt ggttgggttt    840

tgatacgaaa agctgctacg tttggtgacc agagggaggg tttggaatct gtgctttgca    900

ggggatctcg gtgggtaccg cggcccctcg cagggtggcg agtggggtcc gtgcctcgag    960

aagggggccc ttacccacac cgtgcggctt gaattctgtc ggagttgaat ctgtggaaag   1020

gattgtccca ttagagctgc tgcgtccttt cctctgtcct ccctgtcacc caaaccccga   1080

agtcacagct gcttagaaga atgggatttt ggggatacaa ccacacacat ttccctctgg   1140

actgaaattt taaaaacaga cccatttcat gacttcttta gggaaaatag tttcagtctt   1200

gggttgtctt gtgagcccac gggcatggga ccctgtctct gctgggcttt tccggccccg   1260

tcccagctcc tcctcaggca gaggctgcag ccctcagctc tgctgctgga tggaacattt   1320

caaccccctc cgggaaggtg ggcagggtgg agggcccagg gctaggcctg ccatgcacca   1380

tgagcagggg tgctacctgg gtgtgtgaag ttgggctggc ttttcctgga ggtgggtgag   1440

aaggctctcc gggcaaatca gaaggccacg agagagagag gagcggggag agtggtgagg   1500

aggattcgtc tctgactgat gaacctcgcc gtgcctgtct gtcacatcca agtctgtgcc   1560

agctgctggg aggtcagact cctgccctga gaaacagccc agtccttgga gaatgaaacc   1620

ctgagggtca gtgagtggag gccttccctc ggggccagcc attcccggga ggcctgagtg   1680

tgacctggaa gctctgtggg tcaccaagac tggcattttc cttgtatttt tgtgcagggc   1740

tgaagtgagc gttcctcctc tgaattggtg aggctttgga aattttttgt ttcttctact   1800

catcctaatg gctggttttg gctgcccgga gtatcagaga atatcactaa gagggcagtc   1860

agtttatttt taggcatctt tctttctgtc cagggagaaa cccctcggaa gaatcttagt   1920

cactctttgc acctgccctg tcattctcgc catggggaaa atgcgttgaa aagaaaaata   1980

ccggggccag ggagaagccg tgaatgtatt tatttgcttt ggtgaagctg ctgaacactg   2040

gctgcggagg gccccccgcc cccatcccgc ttcaggcccc agtgacccag ttgcgtctta   2100

agttccatcg tccagatttc aggccaccag aggctgccaa aggtgactga agcggtctcc   2160

aagtcactct gtcaccatca aatcaagtat tttaagtttg gctcttcttt ttttcaagaa   2220

aggctttttg gatacctaga ataccttcat gtatgtggct tgatttctgt ttcaggaaaa   2280

ggggggcggg aggagagaca acagccgtgt tccagagtct gtcctgagat gtcgctgagt   2340

ccagacactt gggctgcacg tgccctgcag atgacaaagg ccggcagctc agcacacgtg   2400

caggaggggt taaagccaat attgagtttt tgttcttgtt gttttaatct gaacgattat   2460

tctcctgtaa aaataatttg ggaggggcgg gtgttgttcg gtgtgtgtgt gtgtgtgtgt   2520

gtgtgtgtgt gtgtgtgtat tttttttttt acagtggcgc ctgtctaaag tatttttcac   2580

aacatgtttg ataatcagtg ctttaaaaag cagcagtgtc ctatgaagtg gaaatgtcag   2640

ttctagagca ttggatgtga agttctggtc atgtcacctt gcgtgtctca ccctggagga   2700

gtgaaggtgg gcgcccggcg ggggggtgtg gctgcacccc agcaccggga gggggcacgc   2760

acgacaccag aggaagggac agccccaccc atgtcaacag caggcaacct gtgttttcat   2820

ttcaagtggg atacagtatt tttttaataa ggagccatac ttttttttaa gagtttgaga   2880

tctgaatgtg atttctaatt gtatcagacg ttaatgtttt aaagctataa caaagtttaa   2940

aatttctact ttttgttttt catttatttt aactgttctt ttatctatta aattgttgta   3000

tgtggatggg gaagttttgt ttctcctctt agcatttgtt tctataacca gaaataaaat   3060

tctatattaa agaaatgacc ctgcggctcc ggtgtggtcc ttctgcgcag gtggctactg   3120

aaggtggcgg acggacagac ggcctggaca cacagacacc aggcccctgg acacataggc   3180

tcccgacccc ctggatacac aaacacctga ccccctggac acacaggctc ctgacccccg   3240

gacacacaga cccctgagcc cctagacata caggcacctg gccccctgga cacagaggct   3300

cccgaccccc tagacataca ggctcccggc cccctggaca cacaggcccc tgaccccctg   3360

gacacacagg cccctgaccc cctggacaca cagacccctg acccctggac acacagaccc   3420

ctgagcccct ggacatacag gctcccgg                                      3448


<210>  3527
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  3527

Met Thr Ser Leu Gly Lys Ile Val Ser Val Leu Gly Cys Leu Val Ser 
1               5                   10                  15


Pro Arg Ala Trp Asp Pro Val Ser Ala Gly Leu Phe Arg Pro Arg Pro 
            20                  25                  30


Ser Ser Ser Ser Gly Arg Gly Cys Ser Pro Gln Leu Cys Cys Trp Met 
        35                  40                  45


Glu His Phe Asn Pro Leu Arg Glu Gly Gly Gln Gly Gly Gly Pro Arg 
    50                  55                  60


Ala Arg Pro Ala Met His His Glu Gln Gly Cys Tyr Leu Gly Val 
65                  70                  75


<210>  3528
<211>  1660
<212>  DNA
<213>  Homo sapiens

<400>  3528
tttagggaaa atagtttcag tcttgggttg tcttgtgagc ccacgggcat gggaccctgt     60

ctctgctggg cttttccggc cccgtcccag ctcctcctca ggcagaggct gcagccctca    120

gctctgctgc tggatggaac atttcaaccc cctccgggaa ggtgggcagg gtggagggcc    180

cagggctagg cctgccatgc accatgagca ggggtgctac ctgggtgtgt gaagttgggc    240

tggcttttcc tggaggtggg tgagaaggct ctccgggcaa atcagaaggc cacgagagag    300

agaggagcgg ggagagtggt gaggaggatt cgtctctgac tgatgaacct cgccgtgcct    360

gtctgtcaca tccaagtctg tgccagctgc tgggaggtca gactcctgcc ctgagaaaca    420

gcccagtcct tggagaatga aaccctgagg gtcagtgagt ggaggccttc cctcggggcc    480

agccattccc gggaggcctg agtgtgacct ggaagctctg tgggtcacca agactggcat    540

tttccttgta tttttgtgca gggctgaagt gagcgttcct cctctgaatt ggtgaggctt    600

tggaaatttt ttgtttcttc tactcatcct aatggctggt tttggctgcc cggagtatca    660

gagaatatca ctaagagggc agtcagttta tttttaggca tctttctttc tgtccaggga    720

gaaacccctc ggaagaatct tagtcactct ttgcacctgc cctgtcattc tcgccatggg    780

gaaaatgcgt tgaaaagaaa aataccgggg ccagggagaa gccgtgaatg tatttatttg    840

ctttggtgaa gctgctgaac actggctgcg gaggagagac aacagccgtg ttccagagtc    900

tgtcctgaga tgtcgctgag tccagacact tgggctgcac gtgccctgca gatgacaaag    960

gccggcagct cagcacacgt gcaggagggg ttaaagccaa tattgagttt ttgttcttgt   1020

tgttttaatc tgaacgatta ttctcctgta aaaataattt gggaggggcg ggtgttgttc   1080

ggtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta tttttttttt tacagtggcg   1140

cctgtctaaa gtatttttca caacatgttt gataatcagt gctttaaaaa gcagcagtgt   1200

cctatgaagt ggaaatgtca gttctagagc attggatgtg aagttctggt catgtcacct   1260

tgcgtgtctc accctggagg agtgaaggtg ggcgcccggc gggggggtgt ggctgcaccc   1320

cagcaccggg agggggcacg cacgacacca gaggaaggga cagccccacc catgtcaaca   1380

gcaggcaacc tgtgttttca tttcaagtgg gatacagtat ttttttaata aggagccata   1440

ctttttttta agagtttgag atctgaatgt gatttctaat tgtatcagac gttaatgttt   1500

taaagctata acaaagttta aaatttctac tttttgtttt tcatttattt taactgttct   1560

tttatctatt aaattgttgt atgtggatgg ggaagttttg tttctcctct tagcatttgt   1620

ttctataacc agaaataaaa ttctatatta aagaaatgac                         1660


<210>  3529
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  3529

Met Ser Leu Ser Pro Asp Thr Trp Ala Ala Arg Ala Leu Gln Met Thr 
1               5                   10                  15


Lys Ala Gly Ser Ser Ala His Val Gln Glu Gly Leu Lys Pro Ile Leu 
            20                  25                  30


Ser Phe Cys Ser Cys Cys Phe Asn Leu Asn Asp Tyr Ser Pro Val Lys 
        35                  40                  45


Ile Ile Trp Glu Gly Arg Val Leu Phe Gly Val Cys Val Cys Val Cys 
    50                  55                  60


Val Cys Val Cys Val Cys Ile Phe Phe Phe Thr Val Ala Pro Val 
65                  70                  75


<210>  3530
<211>  1967
<212>  DNA
<213>  Homo sapiens

<400>  3530
tttagggaaa atagtttcag tcttgggttg tcttgtgagc ccacgggcat gggaccctgt     60

ctctgctggg cttttccggc cccgtcccag ctcctcctca ggcagaggct gcagccctca    120

gctctgctgc tggatggaac atttcaaccc cctccgggaa ggtgggcagg gtggagggcc    180

cagggctagg cctgccatgc accatgagca ggggtgctac ctgggtgtgt gaagttgggc    240

tggcttttcc tggaggtggg tgagaaggct ctccgggcaa atcagaaggc cacgagagag    300

agaggagcgg ggagagtggt gaggaggatt cgtctctgac tgatgaacct cgccgtgcct    360

gtctgtcaca tccaagtctg tgccagctgc tgggaggtca gactcctgcc ctgagaaaca    420

gcccagtcct tggagaatga aaccctgagg gtcagtgagt ggaggccttc cctcggggcc    480

agccattccc gggaggcctg agtgtgacct ggaagctctg tgggtcacca agactggcat    540

tttccttgta tttttgtgca gggctgaagt gagcgttcct cctctgaatt ggtgaggctt    600

tggaaatttt ttgtttcttc tactcatcct aatggctggt tttggctgcc cggagtatca    660

gagaatatca ctaagagggc agtcagttta tttttaggca tctttctttc tgtccaggga    720

gaaacccctc ggaagaatct tagtcactct ttgcacctgc cctgtcattc tcgccatggg    780

gaaaatgcgt tgaaaagaaa aataccgggg ccagggagaa gccgtgaatg tatttatttg    840

ctttggtgaa gctgctgaac actggctgcg gagggccccc cgcccccatc ccgcttcagg    900

ccccagtgac ccagttgcgt cttaagttcc atcgtccaga tttcaggcca ccagaggctg    960

ccaaaggtga ctgaagcggt ctccaagtca ctctgtcacc acttttttct gtcacttttt   1020

ttgctcctta cccactgaaa tgagagactc tgaattagag tttttgttta tcaagtattt   1080

taagtttggc tcttcttttt ttcaagaaag gctttttgga tacctagaat accttcatgt   1140

atgtggcttg atttctgttt caggaaaagg ggggcgggag gagagacaac agccgtgttc   1200

cagagtctgt cctgagatgt cgctgagtcc agacacttgg gctgcacgtg ccctgcagat   1260

gacaaaggcc ggcagctcag cacacgtgca ggaggggtta aagccaatat tgagtttttg   1320

ttcttgttgt tttaatctga acgattattc tcctgtaaaa ataatttggg aggggcgggt   1380

gttgttcggt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtattt ttttttttac   1440

agtggcgcct gtctaaagta tttttcacaa catgtttgat aatcagtgct ttaaaaagca   1500

gcagtgtcct atgaagtgga aatgtcagtt ctagagcatt ggatgtgaag ttctggtcat   1560

gtcaccttgc gtgtctcacc ctggaggagt gaaggtgggc gcccggcggg ggggtgtggc   1620

tgcaccccag caccgggagg gggcacgcac gacaccagag gaagggacag ccccacccat   1680

gtcaacagca ggcaacctgt gttttcattt caagtgggat acagtatttt tttaataagg   1740

agccatactt ttttttaaga gtttgagatc tgaatgtgat ttctaattgt atcagacgtt   1800

aatgttttaa agctataaca aagtttaaaa tttctacttt ttgtttttca tttattttaa   1860

ctgttctttt atctattaaa ttgttgtatg tggatgggga agttttgttt ctcctcttag   1920

catttgtttc tataaccaga aataaaattc tatattaaag aaatgac                 1967


<210>  3531
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  3531

Met Arg Asp Ser Glu Leu Glu Phe Leu Phe Ile Lys Tyr Phe Lys Phe 
1               5                   10                  15


Gly Ser Ser Phe Phe Gln Glu Arg Leu Phe Gly Tyr Leu Glu Tyr Leu 
            20                  25                  30


His Val Cys Gly Leu Ile Ser Val Ser Gly Lys Gly Gly Arg Glu Glu 
        35                  40                  45


Arg Gln Gln Pro Cys Ser Arg Val Cys Pro Glu Met Ser Leu Ser Pro 
    50                  55                  60


Asp Thr Trp Ala Ala Arg Ala Leu Gln Met Thr Lys Ala Gly Ser Ser 
65                  70                  75                  80


Ala His Val Gln Glu Gly Leu Lys Pro Ile Leu Ser Phe Cys Ser Cys 
                85                  90                  95


Cys Phe Asn Leu Asn Asp Tyr Ser Pro Val Lys Ile Ile Trp Glu Gly 
            100                 105                 110


Arg Val Leu Phe Gly Val Cys Val Cys Val Cys Val Cys Val Cys Val 
        115                 120                 125


Cys Ile Phe Phe Phe Thr Val Ala Pro Val 
    130                 135


<210>  3532
<211>  2336
<212>  DNA
<213>  Homo sapiens

<400>  3532
tttagggaaa atagtttcag tcttgggttg tcttgtgagc ccacgggcat gggaccctgt     60

ctctgctggg cttttccggc cccgtcccag ctcctcctca ggcagaggct gcagccctca    120

gctctgctgc tggatggaac atttcaaccc cctccgggaa ggtgggcagg gtggagggcc    180

cagggctagg cctgccatgc accatgagca ggggtgctac ctgggtgtgt gaagttgggc    240

tggcttttcc tggaggtggg tgagaaggct ctccgggcaa atcagaaggc cacgagagag    300

agaggagcgg ggagagtggt gaggaggatt cgtctctgac tgatgaacct cgccgtgcct    360

gtctgtcaca tccaagtctg tgccagctgc tgggaggtca gactcctgcc ctgagaaaca    420

gcccagtcct tggagaatga aaccctgagg gtcagtgagt ggaggccttc cctcggggcc    480

agccattccc gggaggcctg agtgtgacct ggaagctctg tgggtcacca agactggcat    540

tttccttgta tttttgtgca gggctgaagt gagcgttcct cctctgaatt ggtgaggctt    600

tggaaatttt ttgtttcttc tactcatcct aatggctggt tttggctgcc cggagtatca    660

gagaatatca ctaagagggc agtcagttta tttttaggca tctttctttc tgtccaggga    720

gaaacccctc ggaagaatct tagtcactct ttgcacctgc cctgtcattc tcgccatggg    780

gaaaatgcgt tgaaaagaaa aataccgggg ccagggagaa gccgtgaatg tatttatttg    840

ctttggtgaa gctgctgaac actggctgcg gagggccccc cgcccccatc ccgcttcagg    900

ccccagtgac ccagttgcgt cttaagttcc atcgtccaga tttcaggcca ccagaggctg    960

ccaaaggtga ctgaagcggt ctccaagtca ctctgtcacc acttttttct gtcacttttt   1020

ttgctcctta cccactgaaa tgagagactc tgaattagag tttttgttta tcaagtattt   1080

taagtttggc tcttcttttt ttcaagaaag gctttttgga tacctagaat accttcatgt   1140

atgtggcttg atttctgttt caggaaaagg ggggcgggag gagagacaac agccgtgttc   1200

cagagtctgt cctgagatgt cgctgagtcc agacacttgg gctgcacgtg ccctgcagat   1260

gacaaaggcc ggcagctcag cacacgtgca ggaggggtta aagccaatat tgagtttttg   1320

ttcttgttgt tttaatctga acgattattc tcctgtaaaa ataatttggg aggggcgggt   1380

gttgttcggt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtattt ttttttttac   1440

agtggcgcct gtctaaagta tttttcacaa catgtttgat aatcagtgct ttaaaaagca   1500

gcagtgtcct atgaagtgga aatgtcagtt ctagagcatt ggatgtgaag ttctggtcat   1560

gtcaccttgc gtgtctcacc ctggaggagt gaaggtgggc gcccggcggg ggggtgtggc   1620

tgcaccccag caccgggagg gggcacgcac gacaccagag gaagggacag ccccacccat   1680

gtcaacagca ggcaacctgt gttttcattt caagtgggat acagtatttt tttaataagg   1740

agccatactt ttttttaaga gtttgagatc tgaatgtgat ttctaattgt atcagacgtt   1800

aatgttttaa agctataaca aagtttaaaa tttctacttt ttgtttttca tttattttaa   1860

ctgttctttt atctattaaa ttgttgtatg tggatgggga agttttgttt ctcctcttag   1920

catttgtttc tataaccaga aataaaattc tatattaaag aaatgaccct gcggctccgg   1980

tgtggtcctt ctgcgcaggt ggctactgaa ggtggcggac ggacagacgg cctggacaca   2040

cagacaccag gcccctggac acataggctc ccgaccccct ggatacacaa acacctgacc   2100

ccctggacac acaggctcct gacccccgga cacacagacc cctgagcccc tagacataca   2160

ggcacctggc cccctggaca cagaggctcc cgacccccta gacatacagg ctcccggccc   2220

cctggacaca caggcccctg accccctgga cacacaggcc cctgaccccc tggacacaca   2280

gacccctgac ccctggacac acagacccct gagcccctgg acatacaggc tcccgg       2336


<210>  3533
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  3533

Met Arg Asp Ser Glu Leu Glu Phe Leu Phe Ile Lys Tyr Phe Lys Phe 
1               5                   10                  15


Gly Ser Ser Phe Phe Gln Glu Arg Leu Phe Gly Tyr Leu Glu Tyr Leu 
            20                  25                  30


His Val Cys Gly Leu Ile Ser Val Ser Gly Lys Gly Gly Arg Glu Glu 
        35                  40                  45


Arg Gln Gln Pro Cys Ser Arg Val Cys Pro Glu Met Ser Leu Ser Pro 
    50                  55                  60


Asp Thr Trp Ala Ala Arg Ala Leu Gln Met Thr Lys Ala Gly Ser Ser 
65                  70                  75                  80


Ala His Val Gln Glu Gly Leu Lys Pro Ile Leu Ser Phe Cys Ser Cys 
                85                  90                  95


Cys Phe Asn Leu Asn Asp Tyr Ser Pro Val Lys Ile Ile Trp Glu Gly 
            100                 105                 110


Arg Val Leu Phe Gly Val Cys Val Cys Val Cys Val Cys Val Cys Val 
        115                 120                 125


Cys Ile Phe Phe Phe Thr Val Ala Pro Val 
    130                 135


<210>  3534
<211>  2029
<212>  DNA
<213>  Homo sapiens

<400>  3534
tttagggaaa atagtttcag tcttgggttg tcttgtgagc ccacgggcat gggaccctgt     60

ctctgctggg cttttccggc cccgtcccag ctcctcctca ggcagaggct gcagccctca    120

gctctgctgc tggatggaac atttcaaccc cctccgggaa ggtgggcagg gtggagggcc    180

cagggctagg cctgccatgc accatgagca ggggtgctac ctgggtgtgt gaagttgggc    240

tggcttttcc tggaggtggg tgagaaggct ctccgggcaa atcagaaggc cacgagagag    300

agaggagcgg ggagagtggt gaggaggatt cgtctctgac tgatgaacct cgccgtgcct    360

gtctgtcaca tccaagtctg tgccagctgc tgggaggtca gactcctgcc ctgagaaaca    420

gcccagtcct tggagaatga aaccctgagg gtcagtgagt ggaggccttc cctcggggcc    480

agccattccc gggaggcctg agtgtgacct ggaagctctg tgggtcacca agactggcat    540

tttccttgta tttttgtgca gggctgaagt gagcgttcct cctctgaatt ggtgaggctt    600

tggaaatttt ttgtttcttc tactcatcct aatggctggt tttggctgcc cggagtatca    660

gagaatatca ctaagagggc agtcagttta tttttaggca tctttctttc tgtccaggga    720

gaaacccctc ggaagaatct tagtcactct ttgcacctgc cctgtcattc tcgccatggg    780

gaaaatgcgt tgaaaagaaa aataccgggg ccagggagaa gccgtgaatg tatttatttg    840

ctttggtgaa gctgctgaac actggctgcg gaggagagac aacagccgtg ttccagagtc    900

tgtcctgaga tgtcgctgag tccagacact tgggctgcac gtgccctgca gatgacaaag    960

gccggcagct cagcacacgt gcaggagggg ttaaagccaa tattgagttt ttgttcttgt   1020

tgttttaatc tgaacgatta ttctcctgta aaaataattt gggaggggcg ggtgttgttc   1080

ggtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta tttttttttt tacagtggcg   1140

cctgtctaaa gtatttttca caacatgttt gataatcagt gctttaaaaa gcagcagtgt   1200

cctatgaagt ggaaatgtca gttctagagc attggatgtg aagttctggt catgtcacct   1260

tgcgtgtctc accctggagg agtgaaggtg ggcgcccggc gggggggtgt ggctgcaccc   1320

cagcaccggg agggggcacg cacgacacca gaggaaggga cagccccacc catgtcaaca   1380

gcaggcaacc tgtgttttca tttcaagtgg gatacagtat ttttttaata aggagccata   1440

ctttttttta agagtttgag atctgaatgt gatttctaat tgtatcagac gttaatgttt   1500

taaagctata acaaagttta aaatttctac tttttgtttt tcatttattt taactgttct   1560

tttatctatt aaattgttgt atgtggatgg ggaagttttg tttctcctct tagcatttgt   1620

ttctataacc agaaataaaa ttctatatta aagaaatgac cctgcggctc cggtgtggtc   1680

cttctgcgca ggtggctact gaaggtggcg gacggacaga cggcctggac acacagacac   1740

caggcccctg gacacatagg ctcccgaccc cctggataca caaacacctg accccctgga   1800

cacacaggct cctgaccccc ggacacacag acccctgagc ccctagacat acaggcacct   1860

ggccccctgg acacagaggc tcccgacccc ctagacatac aggctcccgg ccccctggac   1920

acacaggccc ctgaccccct ggacacacag gcccctgacc ccctggacac acagacccct   1980

gacccctgga cacacagacc cctgagcccc tggacataca ggctcccgg               2029


<210>  3535
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  3535

Met Ser Leu Ser Pro Asp Thr Trp Ala Ala Arg Ala Leu Gln Met Thr 
1               5                   10                  15


Lys Ala Gly Ser Ser Ala His Val Gln Glu Gly Leu Lys Pro Ile Leu 
            20                  25                  30


Ser Phe Cys Ser Cys Cys Phe Asn Leu Asn Asp Tyr Ser Pro Val Lys 
        35                  40                  45


Ile Ile Trp Glu Gly Arg Val Leu Phe Gly Val Cys Val Cys Val Cys 
    50                  55                  60


Val Cys Val Cys Val Cys Ile Phe Phe Phe Thr Val Ala Pro Val 
65                  70                  75


<210>  3536
<211>  2847
<212>  DNA
<213>  Homo sapiens

<400>  3536
cccggaagtt gaccggggtg cggagctcct gggctgcagc tcctggagtt tccgaggttc     60

gtgcgcgtct ggtggcggcg gcgtgatgtt ctcggcagga gcggagagtt tgctccacca    120

ggccagggag atccaggacg aggagctgaa gaagttctgt tcccggatct gtaaactgct    180

gcaggcggag gacttggggc cggacaccct cgactccctg cagaggctct tcctcatcat    240

ctcagccacg aagtacagcc ggaggctgga gaagacatgc gtagacctgc tgcaggccac    300

cctcggcctg cctgcatgcc ccgagcagct ccaggtgctt tgcgccgcca tcctgcgaga    360

gatgtccccc tctgacagcc tcagcctggc ctgggaccac acgcagaaca gccggcagct    420

gagcctggtg gcctccgttc tcttggccca gggtgacaga aacgaggagg tcagagccgt    480

gggccagggc gtgctacgag cgctggagag ccggcagcct gagggaccca gcctcagaca    540

cctcctcccc gtcatggcca agaccaggcc accctgctca gcaagcggct ggtcgactgg    600

ctgcgctacg ccagcctcca gcaagggctc ccacactccg gcggcttctt ctccacgccc    660

agggcccggc agccgggccc cgtcaccgag gtggacgggg cggtagccac agacttcttc    720

acggtgctct ccagcggcca ccgcttcaca gacgaccagt ggctgaacgt gcaggccttc    780

tctatgctgc gggcgtggct gctgcacagc ggccccgagg gcccgggcac cctggacaca    840

gatgacaggt cagagcagga gggctccact ctgtcggtga tctccgccac ctcctctgcc    900

ggccgcctgc tgccgccccg ggagcggctt cgggaggtgg ccttcgagta ctgccagcgc    960

ctcattgagc aaagtaaccg acgagccctg aggaaggggg actccgacct gcagaaagct   1020

tgcctggtgg aggccgtgct ggtgctggac gtgctgtgcc ggcaggaccc gtccttcctg   1080

taccgaagtc tctcctgcct gaaggccctg cacgggcggg tgcgcgggga cccggcctct   1140

gtgcgggtgc tgctgcccct cgcccacttc ttcctgagcc acggggaagc ggctgcagtg   1200

gactcggaag ccgtctacca gcacctgttc accaggatcc cggtggagca gttccacagc   1260

cccatgctgg cctttgaatt catccagttc tgcagggaca acctccacct gttcagcggg   1320

cacctcagca ccctcagatt gagcttcccc aacctcttta agttcctggc ctggaacagc   1380

ccacccctca cctccgagtt tgtggcgctc ctcccggccc tggtggacgc tggcacagcc   1440

ctggagatgc tgcacgcgct gctggacctg ccctgcttga cggcggtgct ggacctgcag   1500

ctcaggtcag caccggctgc atccgagagg ccactctggg acacctctct cagggccccc   1560

agctgcctgg aggccttccg ggacccgcag ttccagggtc ttttccaata cctgctgcgc   1620

cccaaggcca gtggcgccac tgagaggttg gcgccactcc accagctgct gcagcccatg   1680

gccggctgtg cccgcgtggc ccagtgtgcc caggccgtgc ccacgctgct gcaggcattc   1740

ttctcagcag tgacccaggt ggctgacggg tccctgatca accagctggc gctgctgctc   1800

ctgggcagga gcgactcgct ctacccggcc ccagggtacg ctgccggtgt gcacagtgtg   1860

ctgagttctc agttcctggc cctgtgtacg ctgaaaccct ccctggtggt ggagctggca   1920

agagacctgc tggagttcct gggcagcgtg aatggtctct gcagcagggc gagcctcgtc   1980

accagcgtgg tgtgggccat cggcgagtac ctgtcggtga cctacgatcg gaggtgcacc   2040

gtggagcaga tcaacaagtt cttcgaagcc ctggaggctc tgctattcga ggtcacccag   2100

tgccgcccct ctgctgccct gcccaggtgt cccccccagg tggtcaccgt gctgatgacc   2160

acgctgacga agctggcctc ccggagccaa gatctgatcc ccagggcctc tttattgctg   2220

tcaaagatga ggaccctggc tcacagtcca gccaccagct ccacgcacag cgaggagggc   2280

gcggaagcca tccgtacccg ggccacagag ctgctgaccc tgctgaagat gcctagcgtg   2340

gcccagtttg tgctcacacc cagcacggag gtgtgcagcc cccgctatca ccgcgatgcc   2400

aacacggccc tgcccctggc cctgcgcacg gtcagccggc tggtggagag ggaggccggc   2460

ctcatgccag ggtgaaggga cagtggccag ggacttcggt gcagattaag agcctgggca   2520

gccagcttgc tactgaggcc aggctgatag gagctcagga gggcgcggga gtcctgggag   2580

aggaggcaag gcccacggtg ggcttggcac cctcacagac acgcggggct ggcccccctg   2640

ctcaccctct gggctttgtc tccgagcctt ttgctcccag gcaacactga gctgagctga   2700

ggggtgccat ggagcggctc tgattggagg cttgaggccc tgtggctggg tcgggtggag   2760

gctgctgggt ctgtttccta gtcttttgtt tttggacagt tgatgggcaa gaagagctgc   2820

agtaaaagta aatctccttt aataagc                                       2847


<210>  3537
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  3537

Met Leu Arg Ala Trp Leu Leu His Ser Gly Pro Glu Gly Pro Gly Thr 
1               5                   10                  15


Leu Asp Thr Asp Asp Arg Ser Glu Gln Glu Gly Ser Thr Leu Ser Val 
            20                  25                  30


Ile Ser Ala Thr Ser Ser Ala Gly Arg Leu Leu Pro Pro Arg Glu Arg 
        35                  40                  45


Leu Arg Glu Val Ala Phe Glu Tyr Cys Gln Arg Leu Ile Glu Gln Ser 
    50                  55                  60


Asn Arg Arg Ala Leu Arg Lys Gly Asp Ser Asp Leu Gln Lys Ala Cys 
65                  70                  75                  80


Leu Val Glu Ala Val Leu Val Leu Asp Val Leu Cys Arg Gln Asp Pro 
                85                  90                  95


Ser Phe Leu Tyr Arg Ser Leu Ser Cys Leu Lys Ala Leu His Gly Arg 
            100                 105                 110


Val Arg Gly Asp Pro Ala Ser Val Arg Val Leu Leu Pro Leu Ala His 
        115                 120                 125


Phe Phe Leu Ser His Gly Glu Ala Ala Ala Val Asp Ser Glu Ala Val 
    130                 135                 140


Tyr Gln His Leu Phe Thr Arg Ile Pro Val Glu Gln Phe His Ser Pro 
145                 150                 155                 160


Met Leu Ala Phe Glu Phe Ile Gln Phe Cys Arg Asp Asn Leu His Leu 
                165                 170                 175


Phe Ser Gly His Leu Ser Thr Leu Arg Leu Ser Phe Pro Asn Leu Phe 
            180                 185                 190


Lys Phe Leu Ala Trp Asn Ser Pro Pro Leu Thr Ser Glu Phe Val Ala 
        195                 200                 205


Leu Leu Pro Ala Leu Val Asp Ala Gly Thr Ala Leu Glu Met Leu His 
    210                 215                 220


Ala Leu Leu Asp Leu Pro Cys Leu Thr Ala Val Leu Asp Leu Gln Leu 
225                 230                 235                 240


Arg Ser Ala Pro Ala Ala Ser Glu Arg Pro Leu Trp Asp Thr Ser Leu 
                245                 250                 255


Arg Ala Pro Ser Cys Leu Glu Ala Phe Arg Asp Pro Gln Phe Gln Gly 
            260                 265                 270


Leu Phe Gln Tyr Leu Leu Arg Pro Lys Ala Ser Gly Ala Thr Glu Arg 
        275                 280                 285


Leu Ala Pro Leu His Gln Leu Leu Gln Pro Met Ala Gly Cys Ala Arg 
    290                 295                 300


Val Ala Gln Cys Ala Gln Ala Val Pro Thr Leu Leu Gln Ala Phe Phe 
305                 310                 315                 320


Ser Ala Val Thr Gln Val Ala Asp Gly Ser Leu Ile Asn Gln Leu Ala 
                325                 330                 335


Leu Leu Leu Leu Gly Arg Ser Asp Ser Leu Tyr Pro Ala Pro Gly Tyr 
            340                 345                 350


Ala Ala Gly Val His Ser Val Leu Ser Ser Gln Phe Leu Ala Leu Cys 
        355                 360                 365


Thr Leu Lys Pro Ser Leu Val Val Glu Leu Ala Arg Asp Leu Leu Glu 
    370                 375                 380


Phe Leu Gly Ser Val Asn Gly Leu Cys Ser Arg Ala Ser Leu Val Thr 
385                 390                 395                 400


Ser Val Val Trp Ala Ile Gly Glu Tyr Leu Ser Val Thr Tyr Asp Arg 
                405                 410                 415


Arg Cys Thr Val Glu Gln Ile Asn Lys Phe Phe Glu Ala Leu Glu Ala 
            420                 425                 430


Leu Leu Phe Glu Val Thr Gln Cys Arg Pro Ser Ala Ala Leu Pro Arg 
        435                 440                 445


Cys Pro Pro Gln Val Val Thr Val Leu Met Thr Thr Leu Thr Lys Leu 
    450                 455                 460


Ala Ser Arg Ser Gln Asp Leu Ile Pro Arg Ala Ser Leu Leu Leu Ser 
465                 470                 475                 480


Lys Met Arg Thr Leu Ala His Ser Pro Ala Thr Ser Ser Thr His Ser 
                485                 490                 495


Glu Glu Gly Ala Glu Ala Ile Arg Thr Arg Ala Thr Glu Leu Leu Thr 
            500                 505                 510


Leu Leu Lys Met Pro Ser Val Ala Gln Phe Val Leu Thr Pro Ser Thr 
        515                 520                 525


Glu Val Cys Ser Pro Arg Tyr His Arg Asp Ala Asn Thr Ala Leu Pro 
    530                 535                 540


Leu Ala Leu Arg Thr Val Ser Arg Leu Val Glu Arg Glu Ala Gly Leu 
545                 550                 555                 560


Met Pro Gly 



<210>  3538
<211>  3376
<212>  DNA
<213>  Homo sapiens

<400>  3538
cccggaagtt gaccggggtg cggagctcct gggctgcagc tcctggagtt tccgaggttc     60

gtgcgcgtct ggtggcggcg gcgtgatgtt ctcggcagga gcggagagtt tgctccacca    120

ggccagggag atccaggacg aggagctgaa gaagttctgt tcccggatct gtaaactgct    180

gcaggcggag gacttggggc cggacaccct cgactccctg cagaggctct tcctcatcat    240

ctcagccacg aagtacagcc ggaggctgga gaagacatgc gtagacctgc tgcaggccac    300

cctcggcctg cctgcatgcc ccgagcagct ccaggtgctt tgcgccgcca tcctgcgaga    360

gatgtccccc tctgacagcc tcagcctggc ctgggaccac acgcagaaca gccggcagct    420

gagcctggtg gcctccgttc tcttggccca gggtgacaga aacgaggagg tcagagccgt    480

gggccagggc gtgctacgag cgctggagag ccggcagcct gagggaccca gcctcagaca    540

cctcctcccc gtcatggcca agaccaggcc accctgctca gcaagcggct ggtcgactgg    600

ctgcgctacg ccagcctcca gcaagggctc ccacactccg gcggcttctt ctccacgccc    660

agggcccggc agccgggccc cgtcaccgag gtggacgggg cggtagccac agacttcttc    720

acggtgctct ccagcggcca ccgcttcaca gacgaccagt ggctgaacgt gcaggccttc    780

tctatgctgc gggcgtggct gctgcacagc ggccccgagg gcccgggcac cctggacaca    840

gatgacaggt cagagcagga gggctccact ctgtcggtga tctccgccac ctcctctgcc    900

ggccgcctgc tgccgccccg ggagcggctt cgggaggtgg ccttcgagta ctgccagcgc    960

ctcattgagc aaagtaaccg acgagccctg aggaaggggg actccgacct gcagaaagct   1020

tgcctggtgg aggccgtgct ggtgctggac gtgctgtgcc ggcaggaccc gtccttcctg   1080

taccgaagtc tctcctgcct gaaggccctg cacgggcggg tgcgcgggga cccggcctct   1140

gtgcgggtgc tgctgcccct cgcccacttc ttcctgagcc acggggaagc ggctgcagtg   1200

gactcggaag ccgtctacca gcacctgttc accaggatcc cggtggagca gttccacagc   1260

cccatgctgg cctttgaatt catccagttc tgcagggaca acctccacct gttcagcggg   1320

cacctcagca ccctcagatt gagcttcccc aacctcttta agttcctggc ctggaacagc   1380

ccacccctca cctccgagtt tgtggcgctc ctcccggccc tggtggacgc tggcacagcc   1440

ctggagatgc tgcacgcgct gctggacctg ccctgcttga cggcggtgct ggacctgcag   1500

ctcaggtcag caccggctgc atccgagagg ccactctggg acacctctct cagggccccc   1560

agctgcctgg aggccttccg ggacccgcag ttccagggtc ttttccaata cctgctgcgc   1620

cccaaggcca gtggcgccac tgagaggttg gcgccactcc accagctgct gcagcccatg   1680

gccggctgtg cccgcgtggc ccagtgtgcc caggccgtgc ccacgctgct gcaggcattc   1740

ttctcagcag tgacccaggt ggctgacggg tccctgatca accagctggc gctgctgctc   1800

ctgggcagga gcgactcgct ctacccggcc ccagggtacg ctgccggtgt gcacaggtag   1860

gtccctcctg cgctcctgcc acagccctgg gcgggtgcct cctggactcc tccccctctc   1920

ccctcccccc tccccttcag tggcttcggc accaccccta gctgggccct cagcagcctc   1980

agaccctgcc acccccaccc acagccccac acccagcccc aggcacttct ctctgcttct   2040

caagaacatt cccgtccttc tttctgccga gcctgtcctc ttcagggtta gctcaggtcc   2100

ctcttccccg tcttgtcccc tggggtcctt ctctccaaag gcctgatgca tgcaggccca   2160

tcctggttcc actctgagcc tgggcctgag gccagcgctg gtgccagcct tctccccagt   2220

gagaacagtt tctctgaggc tggcagtctt ctgtgttcct ctatcggagg gtgcagcata   2280

cacctaccac tcagacgctt cccgggtttc tccaggccct tggcctggat ggggatgggg   2340

tcataggtct gcacagagca ggcgtagacc cggctttctg ggcagtgtgc tgagttctca   2400

gttcctggcc ctgtgtacgc tgaaaccctc cctggtggtg gagctggcaa gagacctgct   2460

ggagttcctg ggcagcgtga atggtctctg cagcagggcg agcctcgtca ccagcgtggt   2520

gtgggccatc ggcgagtacc tgtcggtgac ctacgatcgg aggtgcaccg tggagcagat   2580

caacaagttc ttcgaagccc tggaggctct gctattcgag gtcacccagt gccgcccctc   2640

tgctgccctg cccaggtgtc ccccccaggt ggtcaccgtg ctgatgacca cgctgacgaa   2700

gctggcctcc cggagccaag atctgatccc cagggcctct ttattgctgt caaagatgag   2760

gaccctggct cacagtccag ccaccagctc cacgcacagc gaggagggcg cggaagccat   2820

ccgtacccgg gccacagagc tgctgaccct gctgaagatg cctagcgtgg cccagtttgt   2880

gctcacaccc agcacggagg tgtgcagccc ccgctatcac cgcgatgcca acacggccct   2940

gcccctggcc ctgcgcacgg tcagccggct ggtggagagg gaggccggcc tcatgccagg   3000

gtgaagggac agtggccagg gacttcggtg cagattaaga gcctgggcag ccagcttgct   3060

actgaggcca ggctgatagg agctcaggag ggcgcgggag tcctgggaga ggaggcaagg   3120

cccacggtgg gcttggcacc ctcacagaca cgcggggctg gcccccctgc tcaccctctg   3180

ggctttgtct ccgagccttt tgctcccagg caacactgag ctgagctgag gggtgccatg   3240

gagcggctct gattggaggc ttgaggccct gtggctgggt cgggtggagg ctgctgggtc   3300

tgtttcctag tcttttgttt ttggacagtt gatgggcaag aagagctgca gtaaaagtaa   3360

atctccttta ataagc                                                   3376


<210>  3539
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  3539

Met Leu Arg Ala Trp Leu Leu His Ser Gly Pro Glu Gly Pro Gly Thr 
1               5                   10                  15


Leu Asp Thr Asp Asp Arg Ser Glu Gln Glu Gly Ser Thr Leu Ser Val 
            20                  25                  30


Ile Ser Ala Thr Ser Ser Ala Gly Arg Leu Leu Pro Pro Arg Glu Arg 
        35                  40                  45


Leu Arg Glu Val Ala Phe Glu Tyr Cys Gln Arg Leu Ile Glu Gln Ser 
    50                  55                  60


Asn Arg Arg Ala Leu Arg Lys Gly Asp Ser Asp Leu Gln Lys Ala Cys 
65                  70                  75                  80


Leu Val Glu Ala Val Leu Val Leu Asp Val Leu Cys Arg Gln Asp Pro 
                85                  90                  95


Ser Phe Leu Tyr Arg Ser Leu Ser Cys Leu Lys Ala Leu His Gly Arg 
            100                 105                 110


Val Arg Gly Asp Pro Ala Ser Val Arg Val Leu Leu Pro Leu Ala His 
        115                 120                 125


Phe Phe Leu Ser His Gly Glu Ala Ala Ala Val Asp Ser Glu Ala Val 
    130                 135                 140


Tyr Gln His Leu Phe Thr Arg Ile Pro Val Glu Gln Phe His Ser Pro 
145                 150                 155                 160


Met Leu Ala Phe Glu Phe Ile Gln Phe Cys Arg Asp Asn Leu His Leu 
                165                 170                 175


Phe Ser Gly His Leu Ser Thr Leu Arg Leu Ser Phe Pro Asn Leu Phe 
            180                 185                 190


Lys Phe Leu Ala Trp Asn Ser Pro Pro Leu Thr Ser Glu Phe Val Ala 
        195                 200                 205


Leu Leu Pro Ala Leu Val Asp Ala Gly Thr Ala Leu Glu Met Leu His 
    210                 215                 220


Ala Leu Leu Asp Leu Pro Cys Leu Thr Ala Val Leu Asp Leu Gln Leu 
225                 230                 235                 240


Arg Ser Ala Pro Ala Ala Ser Glu Arg Pro Leu Trp Asp Thr Ser Leu 
                245                 250                 255


Arg Ala Pro Ser Cys Leu Glu Ala Phe Arg Asp Pro Gln Phe Gln Gly 
            260                 265                 270


Leu Phe Gln Tyr Leu Leu Arg Pro Lys Ala Ser Gly Ala Thr Glu Arg 
        275                 280                 285


Leu Ala Pro Leu His Gln Leu Leu Gln Pro Met Ala Gly Cys Ala Arg 
    290                 295                 300


Val Ala Gln Cys Ala Gln Ala Val Pro Thr Leu Leu Gln Ala Phe Phe 
305                 310                 315                 320


Ser Ala Val Thr Gln Val Ala Asp Gly Ser Leu Ile Asn Gln Leu Ala 
                325                 330                 335


Leu Leu Leu Leu Gly Arg Ser Asp Ser Leu Tyr Pro Ala Pro Gly Tyr 
            340                 345                 350


Ala Ala Gly Val His Arg 
        355


<210>  3540
<211>  2710
<212>  DNA
<213>  Homo sapiens

<400>  3540
cccggaagtt gaccggggtg cggagctcct gggctgcagc tcctggagtt tccgaggttc     60

gtgcgcgtct ggtggcggcg gcgtgatgtt ctcggcagga gcggagagtt tgctccacca    120

ggccagggag atccaggacg aggagctgaa gaagttctgt tcccggatct gtaaactgct    180

gcaggcggag gacttggggc cggacaccct cgactccctg cagaggctct tcctcatcat    240

ctcagccacg aagtacagcc ggaggctgga gaagacatgc gtagacctgc tgcaggccac    300

cctcggcctg cctgcatgcc ccgagcagct ccaggtgctt tgcgccgcca tcctgcgaga    360

gatgtccccc tctgacagcc tcagcctggc ctgggaccac acgcagaaca gccggcagct    420

gagcctggtg gcctccgttc tcttggccca gggtgacaga aacgaggagg tcagagccgt    480

gggccagggc gtgctacgag cgctggagag ccggcagcct gagggaccca gcctcagaca    540

cctcctcccc gtcatggcca agaccaggcc accctgctca gcaagcggct ggtcgactgg    600

ctgcgctacg ccagcctcca gcaagggctc ccacactccg gcggcttctt ctccacgccc    660

agggcccggc agccgggccc cgtcaccgag gtggacgggg cggtagccac agacttcttc    720

acggtgctct ccagcggcca ccgcttcaca gacgaccagt ggctgaacgt gcaggccttc    780

tctatgctgc gggcgtggct gctgcacagc ggccccgagg gcccgggcac cctggacaca    840

gatgacaggt cagagcagga gggctccact ctgtcggtga tctccgccac ctcctctgcc    900

ggccgcctgc tgccgccccg ggagcggctt cgggaggtgg ccttcgagta ctgccagcgc    960

ctcattgagc aaagtaaccg acgagccctg aggaaggggg actccgacct gcagaaagct   1020

tgcctggtgg aggccgtgct ggtgctggac gtgctgtgcc ggcaggaccc gtccttcctg   1080

taccgaagtc tctcctgcct gaaggccctg cacgggcggg tgcgcgggga cccggcctct   1140

gtgcgggtgc tgctgcccct cgcccacttc ttcctgagcc acggggaagc ggctgcagtg   1200

gactcggaag ccgtctacca gcacctgttc accaggatcc cggtggagca gttccacagc   1260

cccatgctgg cctttgaatt catccagttc tgcagggaca acctccacct gttcagcggg   1320

cacctcagca ccctcagatt gagcttcccc aacctcttta agttcctggc ctggaacagc   1380

ccacccctca cctccgagtt tgtggcgctc ctcccggccc tggtggacgc tggcacagcc   1440

ctggagatgc tgcacgcgct gctggacctg ccctgcttga cggcggtgct ggacctgcag   1500

ctcaggtcag caccggctgc atccgagagg ccactctggg acacctctct cagggccccc   1560

agctgcctgg aggccttccg ggacccgcag ttccagggtc ttttccaata cctgctgcgc   1620

cccaaggcca gtggcgccac tgagaggttg gcgccactcc accagctgct gcagcccatg   1680

gccggctgtg cccgcgtggc ccagtgtgcc caggccgtgc ccacgctgct gcaggcattc   1740

ttctcagcag tgacccaggt ggctgacggg tccctgatca accagctggc gctgctgctc   1800

ctgggcagga gcgactcgct ctacccggcc ccagggtacg ctgccggtgt gcacagtgtg   1860

ctgagttctc agttcctggc cctgtgtacg ctgaaaccct ccctggtggt ggagctggca   1920

agagacctgc tggagttcct gggcagcgtg aatggtctct gcagcagggc gagcctcgtc   1980

accagcgtgg tgtccccccc aggtggtcac cgtgctgatg accacgctga cgaagctggc   2040

ctcccggagc caagatctga tccccagggc ctctttattg ctgtcaaaga tgaggaccct   2100

ggctcacagt ccagccacca gctccacgca cagcgaggag ggcgcggaag ccatccgtac   2160

ccgggccaca gagctgctga ccctgctgaa gatgcctagc gtggcccagt ttgtgctcac   2220

acccagcacg gaggtgtgca gcccccgcta tcaccgcgat gccaacacgg ccctgcccct   2280

ggccctgcgc acggtcagcc ggctggtgga gagggaggcc ggcctcatgc cagggtgaag   2340

ggacagtggc cagggacttc ggtgcagatt aagagcctgg gcagccagct tgctactgag   2400

gccaggctga taggagctca ggagggcgcg ggagtcctgg gagaggaggc aaggcccacg   2460

gtgggcttgg caccctcaca gacacgcggg gctggccccc ctgctcaccc tctgggcttt   2520

gtctccgagc cttttgctcc caggcaacac tgagctgagc tgaggggtgc catggagcgg   2580

ctctgattgg aggcttgagg ccctgtggct gggtcgggtg gaggctgctg ggtctgtttc   2640

ctagtctttt gtttttggac agttgatggg caagaagagc tgcagtaaaa gtaaatctcc   2700

tttaataagc                                                          2710


<210>  3541
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  3541

Met Leu Arg Ala Trp Leu Leu His Ser Gly Pro Glu Gly Pro Gly Thr 
1               5                   10                  15


Leu Asp Thr Asp Asp Arg Ser Glu Gln Glu Gly Ser Thr Leu Ser Val 
            20                  25                  30


Ile Ser Ala Thr Ser Ser Ala Gly Arg Leu Leu Pro Pro Arg Glu Arg 
        35                  40                  45


Leu Arg Glu Val Ala Phe Glu Tyr Cys Gln Arg Leu Ile Glu Gln Ser 
    50                  55                  60


Asn Arg Arg Ala Leu Arg Lys Gly Asp Ser Asp Leu Gln Lys Ala Cys 
65                  70                  75                  80


Leu Val Glu Ala Val Leu Val Leu Asp Val Leu Cys Arg Gln Asp Pro 
                85                  90                  95


Ser Phe Leu Tyr Arg Ser Leu Ser Cys Leu Lys Ala Leu His Gly Arg 
            100                 105                 110


Val Arg Gly Asp Pro Ala Ser Val Arg Val Leu Leu Pro Leu Ala His 
        115                 120                 125


Phe Phe Leu Ser His Gly Glu Ala Ala Ala Val Asp Ser Glu Ala Val 
    130                 135                 140


Tyr Gln His Leu Phe Thr Arg Ile Pro Val Glu Gln Phe His Ser Pro 
145                 150                 155                 160


Met Leu Ala Phe Glu Phe Ile Gln Phe Cys Arg Asp Asn Leu His Leu 
                165                 170                 175


Phe Ser Gly His Leu Ser Thr Leu Arg Leu Ser Phe Pro Asn Leu Phe 
            180                 185                 190


Lys Phe Leu Ala Trp Asn Ser Pro Pro Leu Thr Ser Glu Phe Val Ala 
        195                 200                 205


Leu Leu Pro Ala Leu Val Asp Ala Gly Thr Ala Leu Glu Met Leu His 
    210                 215                 220


Ala Leu Leu Asp Leu Pro Cys Leu Thr Ala Val Leu Asp Leu Gln Leu 
225                 230                 235                 240


Arg Ser Ala Pro Ala Ala Ser Glu Arg Pro Leu Trp Asp Thr Ser Leu 
                245                 250                 255


Arg Ala Pro Ser Cys Leu Glu Ala Phe Arg Asp Pro Gln Phe Gln Gly 
            260                 265                 270


Leu Phe Gln Tyr Leu Leu Arg Pro Lys Ala Ser Gly Ala Thr Glu Arg 
        275                 280                 285


Leu Ala Pro Leu His Gln Leu Leu Gln Pro Met Ala Gly Cys Ala Arg 
    290                 295                 300


Val Ala Gln Cys Ala Gln Ala Val Pro Thr Leu Leu Gln Ala Phe Phe 
305                 310                 315                 320


Ser Ala Val Thr Gln Val Ala Asp Gly Ser Leu Ile Asn Gln Leu Ala 
                325                 330                 335


Leu Leu Leu Leu Gly Arg Ser Asp Ser Leu Tyr Pro Ala Pro Gly Tyr 
            340                 345                 350


Ala Ala Gly Val His Ser Val Leu Ser Ser Gln Phe Leu Ala Leu Cys 
        355                 360                 365


Thr Leu Lys Pro Ser Leu Val Val Glu Leu Ala Arg Asp Leu Leu Glu 
    370                 375                 380


Phe Leu Gly Ser Val Asn Gly Leu Cys Ser Arg Ala Ser Leu Val Thr 
385                 390                 395                 400


Ser Val Val Ser Pro Pro Gly Gly His Arg Ala Asp Asp His Ala Asp 
                405                 410                 415


Glu Ala Gly Leu Pro Glu Pro Arg Ser Asp Pro Gln Gly Leu Phe Ile 
            420                 425                 430


Ala Val Lys Asp Glu Asp Pro Gly Ser Gln Ser Ser His Gln Leu His 
        435                 440                 445


Ala Gln Arg Gly Gly Arg Gly Ser His Pro Tyr Pro Gly His Arg Ala 
    450                 455                 460


Ala Asp Pro Ala Glu Asp Ala 
465                 470


<210>  3542
<211>  2917
<212>  DNA
<213>  Homo sapiens

<400>  3542
cccggaagtt gaccggggtg cggagctcct gggctgcagc tcctggagtt tccgaggttc     60

gtgcgcgtct ggtggcggcg gcgtgatgtt ctcggcagga gcggagagtt tgctccacca    120

ggccagggag atccaggacg aggagctgaa gaagttctgt tcccggatct gtaaactgct    180

gcaggcggag gacttggggc cggacaccct cgactccctg cagaggctct tcctcatcat    240

ctcagccacg aagtacagcc ggaggctgga gaagacatgc gtagacctgc tgcaggccac    300

cctcggcctg cctgcatgcc ccgagcagct ccaggtgctt tgcgccgcca tcctgcgaga    360

gatgtccccc tctgacagcc tcagcctggc ctgggaccac acgcagaaca gccggcagct    420

gagcctggtg gcctccgttc tcttggccca gggtgacaga aacgaggagg tcagagccgt    480

gggccagggc gtgctacgag cgctggagag ccggcagcct gagggaccca gcctcagaca    540

cctcctcccc gtcatggcca agaccaggcc accctgctca gcaagcggct ggtcgactgg    600

ctgcgctacg ccagcctcca gcaagggctc ccacactccg gcggcttctt ctccacgccc    660

agggcccggc agccgggccc cgtcaccgag gtggacgggg cggtagccac agacttcttc    720

acggtgctct ccagcggcca ccgcttcaca gacgaccagt ggctgaacgt gcaggccttc    780

tctatgctgc gggcgtggct gctgcacagc ggccccgagg gcccgggcac cctggacaca    840

gatgacaggt cagagcagga gggctccact ctgtcggtga tctccgccac ctcctctgcc    900

ggccgcctgc tgccgccccg ggagcggctt cgggaggtgg ccttcgagta ctgccagcgc    960

ctcattgagc aaagtaaccg acgagccctg aggaaggggg actccgacct gcagaaagct   1020

tgcctggtgg aggccgtgct ggtgctggac gtgctgtgcc ggcaggaccc gtccttcctg   1080

taccgaagtc tctcctgcct gaaggccctg cacgggcggg tgcgcgggga cccggcctct   1140

gtgcgggtgc tgctgcccct cgcccacttc ttcctgagcc acggggaagc ggctgcagtg   1200

gactcggaag ccgtctacca gcacctgttc accaggatcc cggtggagca gttccacagc   1260

cccatgctgg cctttgaatt catccagttc tgcagggaca acctccacct gttcagcggg   1320

cacctcagca ccctcagatt gagcttcccc aacctcttta agttcctggc ctggaacagc   1380

ccacccctca cctccgagtt tgtggcgctc ctcccggccc tggtggacgc tggcacagcc   1440

ctggagatgc tgcacgcgct gctggacctg ccctgcttga cggcggtgct ggacctgcag   1500

ctcaggtcag caccggctgc atccgagagg ccactctggg acacctctct cagggccccc   1560

agctgcctgg aggccttccg ggacccgcag ttccagggtc ttttccaata cctgctgcgc   1620

cccaaggcca gtggcgccac tgagaggttg gcgccactcc accagctgct gcagcccatg   1680

gccggctgtg cccgcgtggc ccagtgtgcc caggccgtgc ccacgctgct gcaggcattc   1740

ttctcagcag tgacccaggt ggctgacggg tccctgatca accagctggc gctgctgctc   1800

ctgggcagga gcgactcgct ctacccggcc ccagggtacg ctgccggtgt gcacaggccc   1860

ttggcctgga tggggatggg gtcataggtc tgcacagagc aggcgtagac ccggctttct   1920

gggcagtgtg ctgagttctc agttcctggc cctgtgtacg ctgaaaccct ccctggtggt   1980

ggagctggca agagacctgc tggagttcct gggcagcgtg aatggtctct gcagcagggc   2040

gagcctcgtc accagcgtgg tgtgggccat cggcgagtac ctgtcggtga cctacgatcg   2100

gaggtgcacc gtggagcaga tcaacaagtt cttcgaagcc ctggaggctc tgctattcga   2160

ggtcacccag tgccgcccct ctgctgccct gcccaggtgt cccccccagg tggtcaccgt   2220

gctgatgacc acgctgacga agctggcctc ccggagccaa gatctgatcc ccagggcctc   2280

tttattgctg tcaaagatga ggaccctggc tcacagtcca gccaccagct ccacgcacag   2340

cgaggagggc gcggaagcca tccgtacccg ggccacagag ctgctgaccc tgctgaagat   2400

gcctagcgtg gcccagtttg tgctcacacc cagcacggag gtgtgcagcc cccgctatca   2460

ccgcgatgcc aacacggccc tgcccctggc cctgcgcacg gtcagccggc tggtggagag   2520

ggaggccggc ctcatgccag ggtgaaggga cagtggccag ggacttcggt gcagattaag   2580

agcctgggca gccagcttgc tactgaggcc aggctgatag gagctcagga gggcgcggga   2640

gtcctgggag aggaggcaag gcccacggtg ggcttggcac cctcacagac acgcggggct   2700

ggcccccctg ctcaccctct gggctttgtc tccgagcctt ttgctcccag gcaacactga   2760

gctgagctga ggggtgccat ggagcggctc tgattggagg cttgaggccc tgtggctggg   2820

tcgggtggag gctgctgggt ctgtttccta gtcttttgtt tttggacagt tgatgggcaa   2880

gaagagctgc agtaaaagta aatctccttt aataagc                            2917


<210>  3543
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  3543

Met Leu Arg Ala Trp Leu Leu His Ser Gly Pro Glu Gly Pro Gly Thr 
1               5                   10                  15


Leu Asp Thr Asp Asp Arg Ser Glu Gln Glu Gly Ser Thr Leu Ser Val 
            20                  25                  30


Ile Ser Ala Thr Ser Ser Ala Gly Arg Leu Leu Pro Pro Arg Glu Arg 
        35                  40                  45


Leu Arg Glu Val Ala Phe Glu Tyr Cys Gln Arg Leu Ile Glu Gln Ser 
    50                  55                  60


Asn Arg Arg Ala Leu Arg Lys Gly Asp Ser Asp Leu Gln Lys Ala Cys 
65                  70                  75                  80


Leu Val Glu Ala Val Leu Val Leu Asp Val Leu Cys Arg Gln Asp Pro 
                85                  90                  95


Ser Phe Leu Tyr Arg Ser Leu Ser Cys Leu Lys Ala Leu His Gly Arg 
            100                 105                 110


Val Arg Gly Asp Pro Ala Ser Val Arg Val Leu Leu Pro Leu Ala His 
        115                 120                 125


Phe Phe Leu Ser His Gly Glu Ala Ala Ala Val Asp Ser Glu Ala Val 
    130                 135                 140


Tyr Gln His Leu Phe Thr Arg Ile Pro Val Glu Gln Phe His Ser Pro 
145                 150                 155                 160


Met Leu Ala Phe Glu Phe Ile Gln Phe Cys Arg Asp Asn Leu His Leu 
                165                 170                 175


Phe Ser Gly His Leu Ser Thr Leu Arg Leu Ser Phe Pro Asn Leu Phe 
            180                 185                 190


Lys Phe Leu Ala Trp Asn Ser Pro Pro Leu Thr Ser Glu Phe Val Ala 
        195                 200                 205


Leu Leu Pro Ala Leu Val Asp Ala Gly Thr Ala Leu Glu Met Leu His 
    210                 215                 220


Ala Leu Leu Asp Leu Pro Cys Leu Thr Ala Val Leu Asp Leu Gln Leu 
225                 230                 235                 240


Arg Ser Ala Pro Ala Ala Ser Glu Arg Pro Leu Trp Asp Thr Ser Leu 
                245                 250                 255


Arg Ala Pro Ser Cys Leu Glu Ala Phe Arg Asp Pro Gln Phe Gln Gly 
            260                 265                 270


Leu Phe Gln Tyr Leu Leu Arg Pro Lys Ala Ser Gly Ala Thr Glu Arg 
        275                 280                 285


Leu Ala Pro Leu His Gln Leu Leu Gln Pro Met Ala Gly Cys Ala Arg 
    290                 295                 300


Val Ala Gln Cys Ala Gln Ala Val Pro Thr Leu Leu Gln Ala Phe Phe 
305                 310                 315                 320


Ser Ala Val Thr Gln Val Ala Asp Gly Ser Leu Ile Asn Gln Leu Ala 
                325                 330                 335


Leu Leu Leu Leu Gly Arg Ser Asp Ser Leu Tyr Pro Ala Pro Gly Tyr 
            340                 345                 350


Ala Ala Gly Val His Arg Pro Leu Ala Trp Met Gly Met Gly Ser 
        355                 360                 365


<210>  3544
<211>  4164
<212>  DNA
<213>  Homo sapiens

<400>  3544
cccggaagtt gaccggggtg cggagctcct gggctgcagc tcctggagtt tccgaggttc     60

gtgcgcgtct ggtggcggcg gcgtgatgtt ctcggcagga gcggagagtt tgctccacca    120

ggccagggag atccaggacg aggagctgaa gaagttctgt tcccggatct gtaaactgct    180

gcaggcggag gacttggggc cggacaccct cgactccctg cagaggctct tcctcatcat    240

ctcagccacg aagtacagcc ggaggctgga gaagacatgc gtagacctgc tgcaggccac    300

cctcggcctg cctgcatgcc ccgagcagct ccaggtgctt tgcgccgcca tcctgcgaga    360

gatgtccccc tctgacagcc tcagcctggc ctgggaccac acgcagaaca gccggcagct    420

gagcctggtg gcctccgttc tcttggccca gggtgacaga aacgaggagg tcagagccgt    480

gggccagggc gtgctacgag cgctggagag ccggcagcct gagggaccca gcctcagaca    540

cctcctcccc gtcatggcca agaccaggcc accctgctca gcaagcggct ggtcgactgg    600

ctgcgctacg ccagcctcca gcaagggctc ccacactccg gcggcttctt ctccacgccc    660

agggcccggc agccgggccc cgtcaccgag gtggacgggg cggtagccac agacttcttc    720

acggtgctct ccagcggcca ccgcttcaca gacgaccagt ggctgaacgt gcaggccttc    780

tctatgctgc gggcgtggct gctgcacagc ggccccgagg gcccgggcac cctggacaca    840

gatgacaggt cagagcagga gggctccact ctgtcggtga tctccgccac ctcctctgcc    900

ggccgcctgc tgccgccccg ggagcggctt cgggaggtgg ccttcgagta ctgccagcgc    960

ctcattgagc aaagtaaccg acgagccctg aggaaggggg actccgacct gcagaaagct   1020

tgcctggtgg aggccgtgct ggtgctggac gtgctgtgcc ggcaggaccc gtccttcctg   1080

taccgaagtc tctcctgcct gaaggccctg cacgggcggg tgcgcgggga cccggcctct   1140

gtgcgggtgc tgctgcccct cgcccacttc ttcctgagcc acggggaagc ggctgcagtg   1200

gactcggaag ccgtctacca gcacctgttc accaggatcc cggtggagca gttccacagc   1260

cccatgctgg cctttgaatt catccagttc tgcagggaca acctccacct gttcagcggg   1320

cacctcagca ccctcagatt gagcttcccc aacctcttta agttcctggc ctggaacagc   1380

ccacccctca cctccgagtt tgtggcgctc ctcccggccc tggtggacgc tggcacagcc   1440

ctggagatgc tgcacgcgct gctggacctg ccctgcttga cggcggtgct ggacctgcag   1500

ctcaggtcag caccggctgc atccgagagg ccactctggg acacctctct cagggccccc   1560

agctgcctgg aggccttccg ggacccgcag ttccagggtc ttttccaata cctgctgcgc   1620

cccaaggcca gtggcgccac tgagaggttg gcgccactcc accagctgct gcagcccatg   1680

gccggctgtg cccgcgtggc ccagtgtgcc caggccgtgc ccacgctgct gcaggcattc   1740

ttctcagcag tgacccaggt ggctgacggg tccctgatca accagctggc gctgctgctc   1800

ctgggcagga gcgactcgct ctacccggcc ccagggtacg ctgccggtgt gcacaggtag   1860

gtccctcctg cgctcctgcc acagccctgg gcgggtgcct cctggactcc tccccctctc   1920

ccctcccccc tccccttcag tggcttcggc accaccccta gctgggccct cagcagcctc   1980

agaccctgcc acccccaccc acagccccac acccagcccc aggcacttct ctctgcttct   2040

caagaacatt cccgtccttc tttctgccga gcctgtcctc ttcagggtta gctcaggtcc   2100

ctcttccccg tcttgtcccc tggggtcctt ctctccaaag gcctgatgca tgcaggccca   2160

tcctggttcc actctgagcc tgggcctgag gccagcgctg gtgccagcct tctccccagt   2220

gagaacagtt tctctgaggc tggcagtctt ctgtgttcct ctatcggagg gtgcagcata   2280

cacctaccac tcagacgctt cccgggtttc tccaggccct tggcctggat ggggatgggg   2340

tcataggtct gcacagagca ggcgtagacc cggctttctg ggcagtgtgc tgagttctca   2400

gttcctggcc ctgtgtacgc tgaaaccctc cctggtggtg gagctggcaa gagacctgct   2460

ggagttcctg ggcagcgtga atggtctctg cagcagggcg agcctcgtca ccagcgtggt   2520

gtgggccatc ggcgagtacc tgtcggtgac ctacgatcgg aggtgcaccg tggagcagat   2580

caacaagttc ttcgaagccc tggaggctct gctattcgag gtcacccagt gccgcccctc   2640

tgctgccctg cccaggtgtc ccccccaggt ggtcaccgtg ctgatgacca cgctgacgaa   2700

gctggcctcc cggagccaag atctgatccc cagggcctct ttattgctgt caaagatgag   2760

gaccctggct cacagtccag ccaccagctc cacgcacagc gaggagggcg cggaagccat   2820

ccgtacccgg gccacagagc tgctgaccct gctgaagatg cctagcgtgg cccagtttgt   2880

gctcacaccc agcacggagg tgtgcagccc ccgctatcac cgcgatgcca acacggccct   2940

gcccctggcc ctgcgcacgg tcagccggct ggtggagagg gaggccggcc tcatgccagg   3000

gtgaagggac agtggccagg gacttcggtg cagattaaga gcctgggcag ccagcttgct   3060

actgaggcca ggctgatagg agctcaggag ggcgcgggag tcctgggaga ggaggcaagg   3120

cccacggtgg gcttggcacc ctcacagaca cgcggggctg gcccccctgc tcaccctctg   3180

ggctttgtct ccgagccttt tgctcccagg caacactgag ctgagctgag gggtgccatg   3240

gagcggctct gattggaggc ttgaggccct gtggctgggt cgggtggagg ctgctgggtc   3300

tgtttcctag tcttttgttt ttggacagtt gatgggcaag aagagctgca gtaaaagtaa   3360

atctccttta ataagcgtct gtatgaagag tgcgcgatca gttccgttac ctgccctgca   3420

ccctggggag aggaccaggg atgggaaccc ctggcagctg ctgccagtcc tggaggctca   3480

gcccggcgtg ccactgctgc tacagaaacc aggtcatttg tgcacagccc ggaaggcagc   3540

ggcgcgagtt cccgggtgtg gtcaccgctc tgggtggtgc gcttgtcaat gccccttttg   3600

atgcccttga atagcctgaa gatgaagggg accgggggag ggttgcaagc gccatggcct   3660

atgcaggctg cggcctctgg ccattcggag ggaaggcccc agggagccac ctgagtggag   3720

ctcagaacac tggattcgcg cgaaggggag gtgtctgggc gtgcggcccc agccccgcca   3780

ccttcctggg ccctgtggtc ccaccctccg gactaccaag gcacagctgt gtcgcacgtt   3840

ccgcccggtg cctgggacgg gctcagccgc cagggggcgc cgccgccccg agagcctcac   3900

gccccgcccc caggctcaaa ctcttccccc tccccactct ggctccgccc ccggtctcct   3960

cttttgctct ggccccgccc acctcccctc cggcctcggc cccgccccca atcccccata   4020

gctctgcgac taagaaacca caggctgaag gcgactgcag ggtcctgccc cttgcccagc   4080

ctcaggacta tggagggggc gagtgacgcg caaggaacgg agcaggggac accgtgcggg   4140

ctcaggagct ccccagatgc ccga                                          4164


<210>  3545
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  3545

Met Leu Arg Ala Trp Leu Leu His Ser Gly Pro Glu Gly Pro Gly Thr 
1               5                   10                  15


Leu Asp Thr Asp Asp Arg Ser Glu Gln Glu Gly Ser Thr Leu Ser Val 
            20                  25                  30


Ile Ser Ala Thr Ser Ser Ala Gly Arg Leu Leu Pro Pro Arg Glu Arg 
        35                  40                  45


Leu Arg Glu Val Ala Phe Glu Tyr Cys Gln Arg Leu Ile Glu Gln Ser 
    50                  55                  60


Asn Arg Arg Ala Leu Arg Lys Gly Asp Ser Asp Leu Gln Lys Ala Cys 
65                  70                  75                  80


Leu Val Glu Ala Val Leu Val Leu Asp Val Leu Cys Arg Gln Asp Pro 
                85                  90                  95


Ser Phe Leu Tyr Arg Ser Leu Ser Cys Leu Lys Ala Leu His Gly Arg 
            100                 105                 110


Val Arg Gly Asp Pro Ala Ser Val Arg Val Leu Leu Pro Leu Ala His 
        115                 120                 125


Phe Phe Leu Ser His Gly Glu Ala Ala Ala Val Asp Ser Glu Ala Val 
    130                 135                 140


Tyr Gln His Leu Phe Thr Arg Ile Pro Val Glu Gln Phe His Ser Pro 
145                 150                 155                 160


Met Leu Ala Phe Glu Phe Ile Gln Phe Cys Arg Asp Asn Leu His Leu 
                165                 170                 175


Phe Ser Gly His Leu Ser Thr Leu Arg Leu Ser Phe Pro Asn Leu Phe 
            180                 185                 190


Lys Phe Leu Ala Trp Asn Ser Pro Pro Leu Thr Ser Glu Phe Val Ala 
        195                 200                 205


Leu Leu Pro Ala Leu Val Asp Ala Gly Thr Ala Leu Glu Met Leu His 
    210                 215                 220


Ala Leu Leu Asp Leu Pro Cys Leu Thr Ala Val Leu Asp Leu Gln Leu 
225                 230                 235                 240


Arg Ser Ala Pro Ala Ala Ser Glu Arg Pro Leu Trp Asp Thr Ser Leu 
                245                 250                 255


Arg Ala Pro Ser Cys Leu Glu Ala Phe Arg Asp Pro Gln Phe Gln Gly 
            260                 265                 270


Leu Phe Gln Tyr Leu Leu Arg Pro Lys Ala Ser Gly Ala Thr Glu Arg 
        275                 280                 285


Leu Ala Pro Leu His Gln Leu Leu Gln Pro Met Ala Gly Cys Ala Arg 
    290                 295                 300


Val Ala Gln Cys Ala Gln Ala Val Pro Thr Leu Leu Gln Ala Phe Phe 
305                 310                 315                 320


Ser Ala Val Thr Gln Val Ala Asp Gly Ser Leu Ile Asn Gln Leu Ala 
                325                 330                 335


Leu Leu Leu Leu Gly Arg Ser Asp Ser Leu Tyr Pro Ala Pro Gly Tyr 
            340                 345                 350


Ala Ala Gly Val His Arg 
        355


<210>  3546
<211>  3532
<212>  DNA
<213>  Homo sapiens

<400>  3546
cccggaagtt gaccggggtg cggagctcct gggctgcagc tcctggagtt tccgaggttc     60

gtgcgcgtct ggtggcggcg gcgtgatgtt ctcggcagga gcggagagtt tgctccacca    120

ggccagggag atccaggacg aggagctgaa gaagttctgt tcccggatct gtaaactgct    180

gcaggcggag gacttggggc cggacaccct cgactccctg cagaggctct tcctcatcat    240

ctcagccacg aagtacagcc ggaggctgga gaagacatgc gtagacctgc tgcaggccac    300

cctcggcctg cctgcatgcc ccgagcagct ccaggtgctt tgcgccgcca tcctgcgaga    360

gatgtccccc tctgacagcc tcagcctggc ctgggaccac acgcagaaca gccggcagct    420

gagcctggtg gcctccgttc tcttggccca gggtgacaga aacgaggagg tcagagccgt    480

gggccagggc gtgctacgag cgctggagag ccggcagcct gagggaccca gcctcagaca    540

cctcctcccc gtcatggcca aggtcgtggt cctcagcccg ggcaccctcc aggaggacca    600

ggccaccctg ctcagcaagc ggctggtcga ctggctgcgc tacgccagcc tccagcaagg    660

gctcccacac tccggcggct tcttctccac gcccagggcc cggcagccgg gccccgtcac    720

cgaggtggac ggggcggtag ccacagactt cttcacggtg ctctccagcg gccaccgctt    780

cacagacgac cagtggctga acgtgcaggc cttctctatg ctgcgggcgt ggctgctgca    840

cagcggcccc gagggcccgg gcaccctgga cacagatgac aggtcagagc aggagggctc    900

cactctgtcg gtgatctccg ccacctcctc tgccggccgc ctgctgccgc cccgggagcg    960

gcttcgggag gtggccttcg agtactgcca gcgcctcatt gagcaaagta accgacgagc   1020

cctgaggaag ggggactccg acctgcagaa agcttgcctg gtggaggccg tgctggtgct   1080

ggacgtgctg tgccggcagg acccgtcctt cctgtaccga agtctctcct gcctgaaggc   1140

cctgcacggg cgggtgcgcg gggacccggc ctctgtgcgg gtgctgctgc ccctcgccca   1200

cttcttcctg agccacgggg aagcggctgc agtggactcg gaagccgtct accagcacct   1260

gttcaccagg atcccggtgg agcagttcca cagccccatg ctggcctttg aattcatcca   1320

gttctgcagg gacaacctcc acctgttcag cgggcacctc agcaccctca gattgagctt   1380

ccccaacctc tttaagttcc tggcctggaa cagcccaccc ctcacctccg agtttgtggc   1440

gctcctcccg gccctggtgg acgctggcac agccctggag atgctgcacg cgctgctgga   1500

cctgccctgc ttgacggcgg tgctggacct gcagctcagg tcagcaccgg ctgcatccga   1560

gaggccactc tgggacacct ctctcagggc ccccagctgc ctggaggcct tccgggaccc   1620

gcagttccag ggtcttttcc aatacctgct gcgccccaag gccagtggcg ccactgagag   1680

gttggcgcca ctccaccagc tgctgcagcc catggccggc tgtgcccgcg tggcccagtg   1740

tgcccaggcc gtgcccacgc tgctgcaggc attcttctca gcagtgaccc aggtggctga   1800

cgggtccctg atcaaccagc tggcgctgct gctcctgggc aggagcgact cgctctaccc   1860

ggccccaggg tacgctgccg gtgtgcacag tgtgctgagt tctcagttcc tggccctgtg   1920

tacgctgaaa ccctccctgg tggtggagct ggcaagagac ctgctggagt tcctgggcag   1980

cgtgaatggt ctctgcagca gggcgagcct cgtcaccagc gtggtgtccc ccccaggtgg   2040

tcaccgtgct gatgaccacg ctgacgaagc tggcctcccg gagccaagat ctgatcccca   2100

gggcctcttt attgctgtca aagatgagga ccctggctca cagtccagcc accagctcca   2160

cgcacagcga ggagggcgcg gaagccatcc gtacccgggc cacagagctg ctgaccctgc   2220

tgaagatgcc tagcgtggcc cagtttgtgc tcacacccag cacggaggtg tgcagccccc   2280

gctatcaccg cgatgccaac acggccctgc ccctggccct gcgcacggtc agccggctgg   2340

tggagaggga ggccggcctc atgccagggt gaagggacag tggccaggga cttcggtgca   2400

gattaagagc ctgggcagcc agcttgctac tgaggccagg ctgataggag ctcaggaggg   2460

cgcgggagtc ctgggagagg aggcaaggcc cacggtgggc ttggcaccct cacagacacg   2520

cggggctggc ccccctgctc accctctggg ctttgtctcc gagccttttg ctcccaggca   2580

acactgagct gagctgaggg gtgccatgga gcggctctga ttggaggctt gaggccctgt   2640

ggctgggtcg ggtggaggct gctgggtctg tttcctagtc ttttgttttt ggacagttga   2700

tgggcaagaa gagctgcagt aaaagtaaat ctcctttaat aagcgtctgt atgaagagtg   2760

cgcgatcagt tccgttacct gccctgcacc ctggggagag gaccagggat gggaacccct   2820

ggcagctgct gccagtcctg gaggctcagc ccggcgtgcc actgctgcta cagaaaccag   2880

gtcatttgtg cacagcccgg aaggcagcgg cgcgagttcc cgggtgtggt caccgctctg   2940

ggtggtgcgc ttgtcaatgc cccttttgat gcccttgaat agcctgaaga tgaaggggac   3000

cgggggaggg ttgcaagcgc catggcctat gcaggctgcg gcctctggcc attcggaggg   3060

aaggccccag ggagccacct gagtggagct cagaacactg gattcgcgcg aaggggaggt   3120

gtctgggcgt gcggccccag ccccgccacc ttcctgggcc ctgtggtccc accctccgga   3180

ctaccaaggc acagctgtgt cgcacgttcc gcccggtgcc tgggacgggc tcagccgcca   3240

gggggcgccg ccgccccgag agcctcacgc cccgccccca ggctcaaact cttccccctc   3300

cccactctgg ctccgccccc ggtctcctct tttgctctgg ccccgcccac ctcccctccg   3360

gcctcggccc cgcccccaat cccccatagc tctgcgacta agaaaccaca ggctgaaggc   3420

gactgcaggg tcctgcccct tgcccagcct caggactatg gagggggcga gtgacgcgca   3480

aggaacggag caggggacac cgtgcgggct caggagctcc ccagatgccc ga           3532


<210>  3547
<211>  715
<212>  PRT
<213>  Homo sapiens

<400>  3547

Met Phe Ser Ala Gly Ala Glu Ser Leu Leu His Gln Ala Arg Glu Ile 
1               5                   10                  15


Gln Asp Glu Glu Leu Lys Lys Phe Cys Ser Arg Ile Cys Lys Leu Leu 
            20                  25                  30


Gln Ala Glu Asp Leu Gly Pro Asp Thr Leu Asp Ser Leu Gln Arg Leu 
        35                  40                  45


Phe Leu Ile Ile Ser Ala Thr Lys Tyr Ser Arg Arg Leu Glu Lys Thr 
    50                  55                  60


Cys Val Asp Leu Leu Gln Ala Thr Leu Gly Leu Pro Ala Cys Pro Glu 
65                  70                  75                  80


Gln Leu Gln Val Leu Cys Ala Ala Ile Leu Arg Glu Met Ser Pro Ser 
                85                  90                  95


Asp Ser Leu Ser Leu Ala Trp Asp His Thr Gln Asn Ser Arg Gln Leu 
            100                 105                 110


Ser Leu Val Ala Ser Val Leu Leu Ala Gln Gly Asp Arg Asn Glu Glu 
        115                 120                 125


Val Arg Ala Val Gly Gln Gly Val Leu Arg Ala Leu Glu Ser Arg Gln 
    130                 135                 140


Pro Glu Gly Pro Ser Leu Arg His Leu Leu Pro Val Met Ala Lys Val 
145                 150                 155                 160


Val Val Leu Ser Pro Gly Thr Leu Gln Glu Asp Gln Ala Thr Leu Leu 
                165                 170                 175


Ser Lys Arg Leu Val Asp Trp Leu Arg Tyr Ala Ser Leu Gln Gln Gly 
            180                 185                 190


Leu Pro His Ser Gly Gly Phe Phe Ser Thr Pro Arg Ala Arg Gln Pro 
        195                 200                 205


Gly Pro Val Thr Glu Val Asp Gly Ala Val Ala Thr Asp Phe Phe Thr 
    210                 215                 220


Val Leu Ser Ser Gly His Arg Phe Thr Asp Asp Gln Trp Leu Asn Val 
225                 230                 235                 240


Gln Ala Phe Ser Met Leu Arg Ala Trp Leu Leu His Ser Gly Pro Glu 
                245                 250                 255


Gly Pro Gly Thr Leu Asp Thr Asp Asp Arg Ser Glu Gln Glu Gly Ser 
            260                 265                 270


Thr Leu Ser Val Ile Ser Ala Thr Ser Ser Ala Gly Arg Leu Leu Pro 
        275                 280                 285


Pro Arg Glu Arg Leu Arg Glu Val Ala Phe Glu Tyr Cys Gln Arg Leu 
    290                 295                 300


Ile Glu Gln Ser Asn Arg Arg Ala Leu Arg Lys Gly Asp Ser Asp Leu 
305                 310                 315                 320


Gln Lys Ala Cys Leu Val Glu Ala Val Leu Val Leu Asp Val Leu Cys 
                325                 330                 335


Arg Gln Asp Pro Ser Phe Leu Tyr Arg Ser Leu Ser Cys Leu Lys Ala 
            340                 345                 350


Leu His Gly Arg Val Arg Gly Asp Pro Ala Ser Val Arg Val Leu Leu 
        355                 360                 365


Pro Leu Ala His Phe Phe Leu Ser His Gly Glu Ala Ala Ala Val Asp 
    370                 375                 380


Ser Glu Ala Val Tyr Gln His Leu Phe Thr Arg Ile Pro Val Glu Gln 
385                 390                 395                 400


Phe His Ser Pro Met Leu Ala Phe Glu Phe Ile Gln Phe Cys Arg Asp 
                405                 410                 415


Asn Leu His Leu Phe Ser Gly His Leu Ser Thr Leu Arg Leu Ser Phe 
            420                 425                 430


Pro Asn Leu Phe Lys Phe Leu Ala Trp Asn Ser Pro Pro Leu Thr Ser 
        435                 440                 445


Glu Phe Val Ala Leu Leu Pro Ala Leu Val Asp Ala Gly Thr Ala Leu 
    450                 455                 460


Glu Met Leu His Ala Leu Leu Asp Leu Pro Cys Leu Thr Ala Val Leu 
465                 470                 475                 480


Asp Leu Gln Leu Arg Ser Ala Pro Ala Ala Ser Glu Arg Pro Leu Trp 
                485                 490                 495


Asp Thr Ser Leu Arg Ala Pro Ser Cys Leu Glu Ala Phe Arg Asp Pro 
            500                 505                 510


Gln Phe Gln Gly Leu Phe Gln Tyr Leu Leu Arg Pro Lys Ala Ser Gly 
        515                 520                 525


Ala Thr Glu Arg Leu Ala Pro Leu His Gln Leu Leu Gln Pro Met Ala 
    530                 535                 540


Gly Cys Ala Arg Val Ala Gln Cys Ala Gln Ala Val Pro Thr Leu Leu 
545                 550                 555                 560


Gln Ala Phe Phe Ser Ala Val Thr Gln Val Ala Asp Gly Ser Leu Ile 
                565                 570                 575


Asn Gln Leu Ala Leu Leu Leu Leu Gly Arg Ser Asp Ser Leu Tyr Pro 
            580                 585                 590


Ala Pro Gly Tyr Ala Ala Gly Val His Ser Val Leu Ser Ser Gln Phe 
        595                 600                 605


Leu Ala Leu Cys Thr Leu Lys Pro Ser Leu Val Val Glu Leu Ala Arg 
    610                 615                 620


Asp Leu Leu Glu Phe Leu Gly Ser Val Asn Gly Leu Cys Ser Arg Ala 
625                 630                 635                 640


Ser Leu Val Thr Ser Val Val Ser Pro Pro Gly Gly His Arg Ala Asp 
                645                 650                 655


Asp His Ala Asp Glu Ala Gly Leu Pro Glu Pro Arg Ser Asp Pro Gln 
            660                 665                 670


Gly Leu Phe Ile Ala Val Lys Asp Glu Asp Pro Gly Ser Gln Ser Ser 
        675                 680                 685


His Gln Leu His Ala Gln Arg Gly Gly Arg Gly Ser His Pro Tyr Pro 
    690                 695                 700


Gly His Arg Ala Ala Asp Pro Ala Glu Asp Ala 
705                 710                 715


<210>  3548
<211>  3635
<212>  DNA
<213>  Homo sapiens

<400>  3548
cccggaagtt gaccggggtg cggagctcct gggctgcagc tcctggagtt tccgaggttc     60

gtgcgcgtct ggtggcggcg gcgtgatgtt ctcggcagga gcggagagtt tgctccacca    120

ggccagggag atccaggacg aggagctgaa gaagttctgt tcccggatct gtaaactgct    180

gcaggcggag gacttggggc cggacaccct cgactccctg cagaggctct tcctcatcat    240

ctcagccacg aagtacagcc ggaggctgga gaagacatgc gtagacctgc tgcaggccac    300

cctcggcctg cctgcatgcc ccgagcagct ccaggtgctt tgcgccgcca tcctgcgaga    360

gatgtccccc tctgacagcc tcagcctggc ctgggaccac acgcagaaca gccggcagct    420

gagcctggtg gcctccgttc tcttggccca gggtgacaga aacgaggagg tcagagccgt    480

gggccagggc gtgctacgag cgctggagag ccggcagcct gagggaccca gcctcagaca    540

cctcctcccc gtcatggcca agaccaggcc accctgctca gcaagcggct ggtcgactgg    600

ctgcgctacg ccagcctcca gcaagggctc ccacactccg gcggcttctt ctccacgccc    660

agggcccggc agccgggccc cgtcaccgag gtggacgggg cggtagccac agacttcttc    720

acggtgctct ccagcggcca ccgcttcaca gacgaccagt ggctgaacgt gcaggccttc    780

tctatgctgc gggcgtggct gctgcacagc ggccccgagg gcccgggcac cctggacaca    840

gatgacaggt cagagcagga gggctccact ctgtcggtga tctccgccac ctcctctgcc    900

ggccgcctgc tgccgccccg ggagcggctt cgggaggtgg ccttcgagta ctgccagcgc    960

ctcattgagc aaagtaaccg acgagccctg aggaaggggg actccgacct gcagaaagct   1020

tgcctggtgg aggccgtgct ggtgctggac gtgctgtgcc ggcaggaccc gtccttcctg   1080

taccgaagtc tctcctgcct gaaggccctg cacgggcggg tgcgcgggga cccggcctct   1140

gtgcgggtgc tgctgcccct cgcccacttc ttcctgagcc acggggaagc ggctgcagtg   1200

gactcggaag ccgtctacca gcacctgttc accaggatcc cggtggagca gttccacagc   1260

cccatgctgg cctttgaatt catccagttc tgcagggaca acctccacct gttcagcggg   1320

cacctcagca ccctcagatt gagcttcccc aacctcttta agttcctggc ctggaacagc   1380

ccacccctca cctccgagtt tgtggcgctc ctcccggccc tggtggacgc tggcacagcc   1440

ctggagatgc tgcacgcgct gctggacctg ccctgcttga cggcggtgct ggacctgcag   1500

ctcaggtcag caccggctgc atccgagagg ccactctggg acacctctct cagggccccc   1560

agctgcctgg aggccttccg ggacccgcag ttccagggtc ttttccaata cctgctgcgc   1620

cccaaggcca gtggcgccac tgagaggttg gcgccactcc accagctgct gcagcccatg   1680

gccggctgtg cccgcgtggc ccagtgtgcc caggccgtgc ccacgctgct gcaggcattc   1740

ttctcagcag tgacccaggt ggctgacggg tccctgatca accagctggc gctgctgctc   1800

ctgggcagga gcgactcgct ctacccggcc ccagggtacg ctgccggtgt gcacagtgtg   1860

ctgagttctc agttcctggc cctgtgtacg ctgaaaccct ccctggtggt ggagctggca   1920

agagacctgc tggagttcct gggcagcgtg aatggtctct gcagcagggc gagcctcgtc   1980

accagcgtgg tgtgggccat cggcgagtac ctgtcggtga cctacgatcg gaggtgcacc   2040

gtggagcaga tcaacaagtt cttcgaagcc ctggaggctc tgctattcga ggtcacccag   2100

tgccgcccct ctgctgccct gcccaggtgt cccccccagg tggtcaccgt gctgatgacc   2160

acgctgacga agctggcctc ccggagccaa gatctgatcc ccagggcctc tttattgctg   2220

tcaaagatga ggaccctggc tcacagtcca gccaccagct ccacgcacag cgaggagggc   2280

gcggaagcca tccgtacccg ggccacagag ctgctgaccc tgctgaagat gcctagcgtg   2340

gcccagtttg tgctcacacc cagcacggag gtgtgcagcc cccgctatca ccgcgatgcc   2400

aacacggccc tgcccctggc cctgcgcacg gtcagccggc tggtggagag ggaggccggc   2460

ctcatgccag ggtgaaggga cagtggccag ggacttcggt gcagattaag agcctgggca   2520

gccagcttgc tactgaggcc aggctgatag gagctcagga gggcgcggga gtcctgggag   2580

aggaggcaag gcccacggtg ggcttggcac cctcacagac acgcggggct ggcccccctg   2640

ctcaccctct gggctttgtc tccgagcctt ttgctcccag gcaacactga gctgagctga   2700

ggggtgccat ggagcggctc tgattggagg cttgaggccc tgtggctggg tcgggtggag   2760

gctgctgggt ctgtttccta gtcttttgtt tttggacagt tgatgggcaa gaagagctgc   2820

agtaaaagta aatctccttt aataagcgtc tgtatgaaga gtgcgcgatc agttccgtta   2880

cctgccctgc accctgggga gaggaccagg gatgggaacc cctggcagct gctgccagtc   2940

ctggaggctc agcccggcgt gccactgctg ctacagaaac caggtcattt gtgcacagcc   3000

cggaaggcag cggcgcgagt tcccgggtgt ggtcaccgct ctgggtggtg cgcttgtcaa   3060

tgcccctttt gatgcccttg aatagcctga agatgaaggg gaccggggga gggttgcaag   3120

cgccatggcc tatgcaggct gcggcctctg gccattcgga gggaaggccc cagggagcca   3180

cctgagtgga gctcagaaca ctggattcgc gcgaagggga ggtgtctggg cgtgcggccc   3240

cagccccgcc accttcctgg gccctgtggt cccaccctcc ggactaccaa ggcacagctg   3300

tgtcgcacgt tccgcccggt gcctgggacg ggctcagccg ccagggggcg ccgccgcccc   3360

gagagcctca cgccccgccc ccaggctcaa actcttcccc ctccccactc tggctccgcc   3420

cccggtctcc tcttttgctc tggccccgcc cacctcccct ccggcctcgg ccccgccccc   3480

aatcccccat agctctgcga ctaagaaacc acaggctgaa ggcgactgca gggtcctgcc   3540

ccttgcccag cctcaggact atggaggggg cgagtgacgc gcaaggaacg gagcagggga   3600

caccgtgcgg gctcaggagc tccccagatg cccga                              3635


<210>  3549
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  3549

Met Leu Arg Ala Trp Leu Leu His Ser Gly Pro Glu Gly Pro Gly Thr 
1               5                   10                  15


Leu Asp Thr Asp Asp Arg Ser Glu Gln Glu Gly Ser Thr Leu Ser Val 
            20                  25                  30


Ile Ser Ala Thr Ser Ser Ala Gly Arg Leu Leu Pro Pro Arg Glu Arg 
        35                  40                  45


Leu Arg Glu Val Ala Phe Glu Tyr Cys Gln Arg Leu Ile Glu Gln Ser 
    50                  55                  60


Asn Arg Arg Ala Leu Arg Lys Gly Asp Ser Asp Leu Gln Lys Ala Cys 
65                  70                  75                  80


Leu Val Glu Ala Val Leu Val Leu Asp Val Leu Cys Arg Gln Asp Pro 
                85                  90                  95


Ser Phe Leu Tyr Arg Ser Leu Ser Cys Leu Lys Ala Leu His Gly Arg 
            100                 105                 110


Val Arg Gly Asp Pro Ala Ser Val Arg Val Leu Leu Pro Leu Ala His 
        115                 120                 125


Phe Phe Leu Ser His Gly Glu Ala Ala Ala Val Asp Ser Glu Ala Val 
    130                 135                 140


Tyr Gln His Leu Phe Thr Arg Ile Pro Val Glu Gln Phe His Ser Pro 
145                 150                 155                 160


Met Leu Ala Phe Glu Phe Ile Gln Phe Cys Arg Asp Asn Leu His Leu 
                165                 170                 175


Phe Ser Gly His Leu Ser Thr Leu Arg Leu Ser Phe Pro Asn Leu Phe 
            180                 185                 190


Lys Phe Leu Ala Trp Asn Ser Pro Pro Leu Thr Ser Glu Phe Val Ala 
        195                 200                 205


Leu Leu Pro Ala Leu Val Asp Ala Gly Thr Ala Leu Glu Met Leu His 
    210                 215                 220


Ala Leu Leu Asp Leu Pro Cys Leu Thr Ala Val Leu Asp Leu Gln Leu 
225                 230                 235                 240


Arg Ser Ala Pro Ala Ala Ser Glu Arg Pro Leu Trp Asp Thr Ser Leu 
                245                 250                 255


Arg Ala Pro Ser Cys Leu Glu Ala Phe Arg Asp Pro Gln Phe Gln Gly 
            260                 265                 270


Leu Phe Gln Tyr Leu Leu Arg Pro Lys Ala Ser Gly Ala Thr Glu Arg 
        275                 280                 285


Leu Ala Pro Leu His Gln Leu Leu Gln Pro Met Ala Gly Cys Ala Arg 
    290                 295                 300


Val Ala Gln Cys Ala Gln Ala Val Pro Thr Leu Leu Gln Ala Phe Phe 
305                 310                 315                 320


Ser Ala Val Thr Gln Val Ala Asp Gly Ser Leu Ile Asn Gln Leu Ala 
                325                 330                 335


Leu Leu Leu Leu Gly Arg Ser Asp Ser Leu Tyr Pro Ala Pro Gly Tyr 
            340                 345                 350


Ala Ala Gly Val His Ser Val Leu Ser Ser Gln Phe Leu Ala Leu Cys 
        355                 360                 365


Thr Leu Lys Pro Ser Leu Val Val Glu Leu Ala Arg Asp Leu Leu Glu 
    370                 375                 380


Phe Leu Gly Ser Val Asn Gly Leu Cys Ser Arg Ala Ser Leu Val Thr 
385                 390                 395                 400


Ser Val Val Trp Ala Ile Gly Glu Tyr Leu Ser Val Thr Tyr Asp Arg 
                405                 410                 415


Arg Cys Thr Val Glu Gln Ile Asn Lys Phe Phe Glu Ala Leu Glu Ala 
            420                 425                 430


Leu Leu Phe Glu Val Thr Gln Cys Arg Pro Ser Ala Ala Leu Pro Arg 
        435                 440                 445


Cys Pro Pro Gln Val Val Thr Val Leu Met Thr Thr Leu Thr Lys Leu 
    450                 455                 460


Ala Ser Arg Ser Gln Asp Leu Ile Pro Arg Ala Ser Leu Leu Leu Ser 
465                 470                 475                 480


Lys Met Arg Thr Leu Ala His Ser Pro Ala Thr Ser Ser Thr His Ser 
                485                 490                 495


Glu Glu Gly Ala Glu Ala Ile Arg Thr Arg Ala Thr Glu Leu Leu Thr 
            500                 505                 510


Leu Leu Lys Met Pro Ser Val Ala Gln Phe Val Leu Thr Pro Ser Thr 
        515                 520                 525


Glu Val Cys Ser Pro Arg Tyr His Arg Asp Ala Asn Thr Ala Leu Pro 
    530                 535                 540


Leu Ala Leu Arg Thr Val Ser Arg Leu Val Glu Arg Glu Ala Gly Leu 
545                 550                 555                 560


Met Pro Gly 



<210>  3550
<211>  3669
<212>  DNA
<213>  Homo sapiens

<400>  3550
cccggaagtt gaccggggtg cggagctcct gggctgcagc tcctggagtt tccgaggttc     60

gtgcgcgtct ggtggcggcg gcgtgatgtt ctcggcagga gcggagagtt tgctccacca    120

ggccagggag atccaggacg aggagctgaa gaagttctgt tcccggatct gtaaactgct    180

gcaggcggag gacttggggc cggacaccct cgactccctg cagaggctct tcctcatcat    240

ctcagccacg aagtacagcc ggaggctgga gaagacatgc gtagacctgc tgcaggccac    300

cctcggcctg cctgcatgcc ccgagcagct ccaggtgctt tgcgccgcca tcctgcgaga    360

gatgtccccc tctgacagcc tcagcctggc ctgggaccac acgcagaaca gccggcagct    420

gagcctggtg gcctccgttc tcttggccca gggtgacaga aacgaggagg tcagagccgt    480

gggccagggc gtgctacgag cgctggagag ccggcagcct gagggaccca gcctcagaca    540

cctcctcccc gtcatggcca aggtcgtggt cctcagcccg ggcaccctcc aggaggacca    600

ggccaccctg ctcagcaagc ggctggtcga ctggctgcgc tacgccagcc tccagcaagg    660

gctcccacac tccggcggct tcttctccac gcccagggcc cggcagccgg gccccgtcac    720

cgaggtggac ggggcggtag ccacagactt cttcacggtg ctctccagcg gccaccgctt    780

cacagacgac cagtggctga acgtgcaggc cttctctatg ctgcgggcgt ggctgctgca    840

cagcggcccc gagggcccgg gcaccctgga cacagatgac aggtcagagc aggagggctc    900

cactctgtcg gtgatctccg ccacctcctc tgccggccgc ctgctgccgc cccgggagcg    960

gcttcgggag gtggccttcg agtactgcca gcgcctcatt gagcaaagta accgacgagc   1020

cctgaggaag ggggactccg acctgcagaa agcttgcctg gtggaggccg tgctggtgct   1080

ggacgtgctg tgccggcagg acccgtcctt cctgtaccga agtctctcct gcctgaaggc   1140

cctgcacggg cgggtgcgcg gggacccggc ctctgtgcgg gtgctgctgc ccctcgccca   1200

cttcttcctg agccacgggg aagcggctgc agtggactcg gaagccgtct accagcacct   1260

gttcaccagg atcccggtgg agcagttcca cagccccatg ctggcctttg aattcatcca   1320

gttctgcagg gacaacctcc acctgttcag cgggcacctc agcaccctca gattgagctt   1380

ccccaacctc tttaagttcc tggcctggaa cagcccaccc ctcacctccg agtttgtggc   1440

gctcctcccg gccctggtgg acgctggcac agccctggag atgctgcacg cgctgctgga   1500

cctgccctgc ttgacggcgg tgctggacct gcagctcagg tcagcaccgg ctgcatccga   1560

gaggccactc tgggacacct ctctcagggc ccccagctgc ctggaggcct tccgggaccc   1620

gcagttccag ggtcttttcc aatacctgct gcgccccaag gccagtggcg ccactgagag   1680

gttggcgcca ctccaccagc tgctgcagcc catggccggc tgtgcccgcg tggcccagtg   1740

tgcccaggcc gtgcccacgc tgctgcaggc attcttctca gcagtgaccc aggtggctga   1800

cgggtccctg atcaaccagc tggcgctgct gctcctgggc aggagcgact cgctctaccc   1860

ggccccaggg tacgctgccg gtgtgcacag tgtgctgagt tctcagttcc tggccctgtg   1920

tacgctgaaa ccctccctgg tggtggagct ggcaagagac ctgctggagt tcctgggcag   1980

cgtgaatggt ctctgcagca gggcgagcct cgtcaccagc gtggtgtggg ccatcggcga   2040

gtacctgtcg gtgacctacg atcggaggtg caccgtggag cagatcaaca agttcttcga   2100

agccctggag gctctgctat tcgaggtcac ccagtgccgc ccctctgctg ccctgcccag   2160

gtgtcccccc caggtggtca ccgtgctgat gaccacgctg acgaagctgg cctcccggag   2220

ccaagatctg atccccaggg cctctttatt gctgtcaaag atgaggaccc tggctcacag   2280

tccagccacc agctccacgc acagcgagga gggcgcggaa gccatccgta cccgggccac   2340

agagctgctg accctgctga agatgcctag cgtggcccag tttgtgctca cacccagcac   2400

ggaggtgtgc agcccccgct atcaccgcga tgccaacacg gccctgcccc tggccctgcg   2460

cacggtcagc cggctggtgg agagggaggc cggcctcatg ccagggtgaa gggacagtgg   2520

ccagggactt cggtgcagat taagagcctg ggcagccagc ttgctactga ggccaggctg   2580

ataggagctc aggagggcgc gggagtcctg ggagaggagg caaggcccac ggtgggcttg   2640

gcaccctcac agacacgcgg ggctggcccc cctgctcacc ctctgggctt tgtctccgag   2700

ccttttgctc ccaggcaaca ctgagctgag ctgaggggtg ccatggagcg gctctgattg   2760

gaggcttgag gccctgtggc tgggtcgggt ggaggctgct gggtctgttt cctagtcttt   2820

tgtttttgga cagttgatgg gcaagaagag ctgcagtaaa agtaaatctc ctttaataag   2880

cgtctgtatg aagagtgcgc gatcagttcc gttacctgcc ctgcaccctg gggagaggac   2940

cagggatggg aacccctggc agctgctgcc agtcctggag gctcagcccg gcgtgccact   3000

gctgctacag aaaccaggtc atttgtgcac agcccggaag gcagcggcgc gagttcccgg   3060

gtgtggtcac cgctctgggt ggtgcgcttg tcaatgcccc ttttgatgcc cttgaatagc   3120

ctgaagatga aggggaccgg gggagggttg caagcgccat ggcctatgca ggctgcggcc   3180

tctggccatt cggagggaag gccccaggga gccacctgag tggagctcag aacactggat   3240

tcgcgcgaag gggaggtgtc tgggcgtgcg gccccagccc cgccaccttc ctgggccctg   3300

tggtcccacc ctccggacta ccaaggcaca gctgtgtcgc acgttccgcc cggtgcctgg   3360

gacgggctca gccgccaggg ggcgccgccg ccccgagagc ctcacgcccc gcccccaggc   3420

tcaaactctt ccccctcccc actctggctc cgcccccggt ctcctctttt gctctggccc   3480

cgcccacctc ccctccggcc tcggccccgc ccccaatccc ccatagctct gcgactaaga   3540

aaccacaggc tgaaggcgac tgcagggtcc tgccccttgc ccagcctcag gactatggag   3600

ggggcgagtg acgcgcaagg aacggagcag gggacaccgt gcgggctcag gagctcccca   3660

gatgcccga                                                           3669


<210>  3551
<211>  807
<212>  PRT
<213>  Homo sapiens

<400>  3551

Met Phe Ser Ala Gly Ala Glu Ser Leu Leu His Gln Ala Arg Glu Ile 
1               5                   10                  15


Gln Asp Glu Glu Leu Lys Lys Phe Cys Ser Arg Ile Cys Lys Leu Leu 
            20                  25                  30


Gln Ala Glu Asp Leu Gly Pro Asp Thr Leu Asp Ser Leu Gln Arg Leu 
        35                  40                  45


Phe Leu Ile Ile Ser Ala Thr Lys Tyr Ser Arg Arg Leu Glu Lys Thr 
    50                  55                  60


Cys Val Asp Leu Leu Gln Ala Thr Leu Gly Leu Pro Ala Cys Pro Glu 
65                  70                  75                  80


Gln Leu Gln Val Leu Cys Ala Ala Ile Leu Arg Glu Met Ser Pro Ser 
                85                  90                  95


Asp Ser Leu Ser Leu Ala Trp Asp His Thr Gln Asn Ser Arg Gln Leu 
            100                 105                 110


Ser Leu Val Ala Ser Val Leu Leu Ala Gln Gly Asp Arg Asn Glu Glu 
        115                 120                 125


Val Arg Ala Val Gly Gln Gly Val Leu Arg Ala Leu Glu Ser Arg Gln 
    130                 135                 140


Pro Glu Gly Pro Ser Leu Arg His Leu Leu Pro Val Met Ala Lys Val 
145                 150                 155                 160


Val Val Leu Ser Pro Gly Thr Leu Gln Glu Asp Gln Ala Thr Leu Leu 
                165                 170                 175


Ser Lys Arg Leu Val Asp Trp Leu Arg Tyr Ala Ser Leu Gln Gln Gly 
            180                 185                 190


Leu Pro His Ser Gly Gly Phe Phe Ser Thr Pro Arg Ala Arg Gln Pro 
        195                 200                 205


Gly Pro Val Thr Glu Val Asp Gly Ala Val Ala Thr Asp Phe Phe Thr 
    210                 215                 220


Val Leu Ser Ser Gly His Arg Phe Thr Asp Asp Gln Trp Leu Asn Val 
225                 230                 235                 240


Gln Ala Phe Ser Met Leu Arg Ala Trp Leu Leu His Ser Gly Pro Glu 
                245                 250                 255


Gly Pro Gly Thr Leu Asp Thr Asp Asp Arg Ser Glu Gln Glu Gly Ser 
            260                 265                 270


Thr Leu Ser Val Ile Ser Ala Thr Ser Ser Ala Gly Arg Leu Leu Pro 
        275                 280                 285


Pro Arg Glu Arg Leu Arg Glu Val Ala Phe Glu Tyr Cys Gln Arg Leu 
    290                 295                 300


Ile Glu Gln Ser Asn Arg Arg Ala Leu Arg Lys Gly Asp Ser Asp Leu 
305                 310                 315                 320


Gln Lys Ala Cys Leu Val Glu Ala Val Leu Val Leu Asp Val Leu Cys 
                325                 330                 335


Arg Gln Asp Pro Ser Phe Leu Tyr Arg Ser Leu Ser Cys Leu Lys Ala 
            340                 345                 350


Leu His Gly Arg Val Arg Gly Asp Pro Ala Ser Val Arg Val Leu Leu 
        355                 360                 365


Pro Leu Ala His Phe Phe Leu Ser His Gly Glu Ala Ala Ala Val Asp 
    370                 375                 380


Ser Glu Ala Val Tyr Gln His Leu Phe Thr Arg Ile Pro Val Glu Gln 
385                 390                 395                 400


Phe His Ser Pro Met Leu Ala Phe Glu Phe Ile Gln Phe Cys Arg Asp 
                405                 410                 415


Asn Leu His Leu Phe Ser Gly His Leu Ser Thr Leu Arg Leu Ser Phe 
            420                 425                 430


Pro Asn Leu Phe Lys Phe Leu Ala Trp Asn Ser Pro Pro Leu Thr Ser 
        435                 440                 445


Glu Phe Val Ala Leu Leu Pro Ala Leu Val Asp Ala Gly Thr Ala Leu 
    450                 455                 460


Glu Met Leu His Ala Leu Leu Asp Leu Pro Cys Leu Thr Ala Val Leu 
465                 470                 475                 480


Asp Leu Gln Leu Arg Ser Ala Pro Ala Ala Ser Glu Arg Pro Leu Trp 
                485                 490                 495


Asp Thr Ser Leu Arg Ala Pro Ser Cys Leu Glu Ala Phe Arg Asp Pro 
            500                 505                 510


Gln Phe Gln Gly Leu Phe Gln Tyr Leu Leu Arg Pro Lys Ala Ser Gly 
        515                 520                 525


Ala Thr Glu Arg Leu Ala Pro Leu His Gln Leu Leu Gln Pro Met Ala 
    530                 535                 540


Gly Cys Ala Arg Val Ala Gln Cys Ala Gln Ala Val Pro Thr Leu Leu 
545                 550                 555                 560


Gln Ala Phe Phe Ser Ala Val Thr Gln Val Ala Asp Gly Ser Leu Ile 
                565                 570                 575


Asn Gln Leu Ala Leu Leu Leu Leu Gly Arg Ser Asp Ser Leu Tyr Pro 
            580                 585                 590


Ala Pro Gly Tyr Ala Ala Gly Val His Ser Val Leu Ser Ser Gln Phe 
        595                 600                 605


Leu Ala Leu Cys Thr Leu Lys Pro Ser Leu Val Val Glu Leu Ala Arg 
    610                 615                 620


Asp Leu Leu Glu Phe Leu Gly Ser Val Asn Gly Leu Cys Ser Arg Ala 
625                 630                 635                 640


Ser Leu Val Thr Ser Val Val Trp Ala Ile Gly Glu Tyr Leu Ser Val 
                645                 650                 655


Thr Tyr Asp Arg Arg Cys Thr Val Glu Gln Ile Asn Lys Phe Phe Glu 
            660                 665                 670


Ala Leu Glu Ala Leu Leu Phe Glu Val Thr Gln Cys Arg Pro Ser Ala 
        675                 680                 685


Ala Leu Pro Arg Cys Pro Pro Gln Val Val Thr Val Leu Met Thr Thr 
    690                 695                 700


Leu Thr Lys Leu Ala Ser Arg Ser Gln Asp Leu Ile Pro Arg Ala Ser 
705                 710                 715                 720


Leu Leu Leu Ser Lys Met Arg Thr Leu Ala His Ser Pro Ala Thr Ser 
                725                 730                 735


Ser Thr His Ser Glu Glu Gly Ala Glu Ala Ile Arg Thr Arg Ala Thr 
            740                 745                 750


Glu Leu Leu Thr Leu Leu Lys Met Pro Ser Val Ala Gln Phe Val Leu 
        755                 760                 765


Thr Pro Ser Thr Glu Val Cys Ser Pro Arg Tyr His Arg Asp Ala Asn 
    770                 775                 780


Thr Ala Leu Pro Leu Ala Leu Arg Thr Val Ser Arg Leu Val Glu Arg 
785                 790                 795                 800


Glu Ala Gly Leu Met Pro Gly 
                805


<210>  3552
<211>  3498
<212>  DNA
<213>  Homo sapiens

<400>  3552
cccggaagtt gaccggggtg cggagctcct gggctgcagc tcctggagtt tccgaggttc     60

gtgcgcgtct ggtggcggcg gcgtgatgtt ctcggcagga gcggagagtt tgctccacca    120

ggccagggag atccaggacg aggagctgaa gaagttctgt tcccggatct gtaaactgct    180

gcaggcggag gacttggggc cggacaccct cgactccctg cagaggctct tcctcatcat    240

ctcagccacg aagtacagcc ggaggctgga gaagacatgc gtagacctgc tgcaggccac    300

cctcggcctg cctgcatgcc ccgagcagct ccaggtgctt tgcgccgcca tcctgcgaga    360

gatgtccccc tctgacagcc tcagcctggc ctgggaccac acgcagaaca gccggcagct    420

gagcctggtg gcctccgttc tcttggccca gggtgacaga aacgaggagg tcagagccgt    480

gggccagggc gtgctacgag cgctggagag ccggcagcct gagggaccca gcctcagaca    540

cctcctcccc gtcatggcca agaccaggcc accctgctca gcaagcggct ggtcgactgg    600

ctgcgctacg ccagcctcca gcaagggctc ccacactccg gcggcttctt ctccacgccc    660

agggcccggc agccgggccc cgtcaccgag gtggacgggg cggtagccac agacttcttc    720

acggtgctct ccagcggcca ccgcttcaca gacgaccagt ggctgaacgt gcaggccttc    780

tctatgctgc gggcgtggct gctgcacagc ggccccgagg gcccgggcac cctggacaca    840

gatgacaggt cagagcagga gggctccact ctgtcggtga tctccgccac ctcctctgcc    900

ggccgcctgc tgccgccccg ggagcggctt cgggaggtgg ccttcgagta ctgccagcgc    960

ctcattgagc aaagtaaccg acgagccctg aggaaggggg actccgacct gcagaaagct   1020

tgcctggtgg aggccgtgct ggtgctggac gtgctgtgcc ggcaggaccc gtccttcctg   1080

taccgaagtc tctcctgcct gaaggccctg cacgggcggg tgcgcgggga cccggcctct   1140

gtgcgggtgc tgctgcccct cgcccacttc ttcctgagcc acggggaagc ggctgcagtg   1200

gactcggaag ccgtctacca gcacctgttc accaggatcc cggtggagca gttccacagc   1260

cccatgctgg cctttgaatt catccagttc tgcagggaca acctccacct gttcagcggg   1320

cacctcagca ccctcagatt gagcttcccc aacctcttta agttcctggc ctggaacagc   1380

ccacccctca cctccgagtt tgtggcgctc ctcccggccc tggtggacgc tggcacagcc   1440

ctggagatgc tgcacgcgct gctggacctg ccctgcttga cggcggtgct ggacctgcag   1500

ctcaggtcag caccggctgc atccgagagg ccactctggg acacctctct cagggccccc   1560

agctgcctgg aggccttccg ggacccgcag ttccagggtc ttttccaata cctgctgcgc   1620

cccaaggcca gtggcgccac tgagaggttg gcgccactcc accagctgct gcagcccatg   1680

gccggctgtg cccgcgtggc ccagtgtgcc caggccgtgc ccacgctgct gcaggcattc   1740

ttctcagcag tgacccaggt ggctgacggg tccctgatca accagctggc gctgctgctc   1800

ctgggcagga gcgactcgct ctacccggcc ccagggtacg ctgccggtgt gcacagtgtg   1860

ctgagttctc agttcctggc cctgtgtacg ctgaaaccct ccctggtggt ggagctggca   1920

agagacctgc tggagttcct gggcagcgtg aatggtctct gcagcagggc gagcctcgtc   1980

accagcgtgg tgtccccccc aggtggtcac cgtgctgatg accacgctga cgaagctggc   2040

ctcccggagc caagatctga tccccagggc ctctttattg ctgtcaaaga tgaggaccct   2100

ggctcacagt ccagccacca gctccacgca cagcgaggag ggcgcggaag ccatccgtac   2160

ccgggccaca gagctgctga ccctgctgaa gatgcctagc gtggcccagt ttgtgctcac   2220

acccagcacg gaggtgtgca gcccccgcta tcaccgcgat gccaacacgg ccctgcccct   2280

ggccctgcgc acggtcagcc ggctggtgga gagggaggcc ggcctcatgc cagggtgaag   2340

ggacagtggc cagggacttc ggtgcagatt aagagcctgg gcagccagct tgctactgag   2400

gccaggctga taggagctca ggagggcgcg ggagtcctgg gagaggaggc aaggcccacg   2460

gtgggcttgg caccctcaca gacacgcggg gctggccccc ctgctcaccc tctgggcttt   2520

gtctccgagc cttttgctcc caggcaacac tgagctgagc tgaggggtgc catggagcgg   2580

ctctgattgg aggcttgagg ccctgtggct gggtcgggtg gaggctgctg ggtctgtttc   2640

ctagtctttt gtttttggac agttgatggg caagaagagc tgcagtaaaa gtaaatctcc   2700

tttaataagc gtctgtatga agagtgcgcg atcagttccg ttacctgccc tgcaccctgg   2760

ggagaggacc agggatggga acccctggca gctgctgcca gtcctggagg ctcagcccgg   2820

cgtgccactg ctgctacaga aaccaggtca tttgtgcaca gcccggaagg cagcggcgcg   2880

agttcccggg tgtggtcacc gctctgggtg gtgcgcttgt caatgcccct tttgatgccc   2940

ttgaatagcc tgaagatgaa ggggaccggg ggagggttgc aagcgccatg gcctatgcag   3000

gctgcggcct ctggccattc ggagggaagg ccccagggag ccacctgagt ggagctcaga   3060

acactggatt cgcgcgaagg ggaggtgtct gggcgtgcgg ccccagcccc gccaccttcc   3120

tgggccctgt ggtcccaccc tccggactac caaggcacag ctgtgtcgca cgttccgccc   3180

ggtgcctggg acgggctcag ccgccagggg gcgccgccgc cccgagagcc tcacgccccg   3240

cccccaggct caaactcttc cccctcccca ctctggctcc gcccccggtc tcctcttttg   3300

ctctggcccc gcccacctcc cctccggcct cggccccgcc cccaatcccc catagctctg   3360

cgactaagaa accacaggct gaaggcgact gcagggtcct gccccttgcc cagcctcagg   3420

actatggagg gggcgagtga cgcgcaagga acggagcagg ggacaccgtg cgggctcagg   3480

agctccccag atgcccga                                                 3498


<210>  3553
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  3553

Met Leu Arg Ala Trp Leu Leu His Ser Gly Pro Glu Gly Pro Gly Thr 
1               5                   10                  15


Leu Asp Thr Asp Asp Arg Ser Glu Gln Glu Gly Ser Thr Leu Ser Val 
            20                  25                  30


Ile Ser Ala Thr Ser Ser Ala Gly Arg Leu Leu Pro Pro Arg Glu Arg 
        35                  40                  45


Leu Arg Glu Val Ala Phe Glu Tyr Cys Gln Arg Leu Ile Glu Gln Ser 
    50                  55                  60


Asn Arg Arg Ala Leu Arg Lys Gly Asp Ser Asp Leu Gln Lys Ala Cys 
65                  70                  75                  80


Leu Val Glu Ala Val Leu Val Leu Asp Val Leu Cys Arg Gln Asp Pro 
                85                  90                  95


Ser Phe Leu Tyr Arg Ser Leu Ser Cys Leu Lys Ala Leu His Gly Arg 
            100                 105                 110


Val Arg Gly Asp Pro Ala Ser Val Arg Val Leu Leu Pro Leu Ala His 
        115                 120                 125


Phe Phe Leu Ser His Gly Glu Ala Ala Ala Val Asp Ser Glu Ala Val 
    130                 135                 140


Tyr Gln His Leu Phe Thr Arg Ile Pro Val Glu Gln Phe His Ser Pro 
145                 150                 155                 160


Met Leu Ala Phe Glu Phe Ile Gln Phe Cys Arg Asp Asn Leu His Leu 
                165                 170                 175


Phe Ser Gly His Leu Ser Thr Leu Arg Leu Ser Phe Pro Asn Leu Phe 
            180                 185                 190


Lys Phe Leu Ala Trp Asn Ser Pro Pro Leu Thr Ser Glu Phe Val Ala 
        195                 200                 205


Leu Leu Pro Ala Leu Val Asp Ala Gly Thr Ala Leu Glu Met Leu His 
    210                 215                 220


Ala Leu Leu Asp Leu Pro Cys Leu Thr Ala Val Leu Asp Leu Gln Leu 
225                 230                 235                 240


Arg Ser Ala Pro Ala Ala Ser Glu Arg Pro Leu Trp Asp Thr Ser Leu 
                245                 250                 255


Arg Ala Pro Ser Cys Leu Glu Ala Phe Arg Asp Pro Gln Phe Gln Gly 
            260                 265                 270


Leu Phe Gln Tyr Leu Leu Arg Pro Lys Ala Ser Gly Ala Thr Glu Arg 
        275                 280                 285


Leu Ala Pro Leu His Gln Leu Leu Gln Pro Met Ala Gly Cys Ala Arg 
    290                 295                 300


Val Ala Gln Cys Ala Gln Ala Val Pro Thr Leu Leu Gln Ala Phe Phe 
305                 310                 315                 320


Ser Ala Val Thr Gln Val Ala Asp Gly Ser Leu Ile Asn Gln Leu Ala 
                325                 330                 335


Leu Leu Leu Leu Gly Arg Ser Asp Ser Leu Tyr Pro Ala Pro Gly Tyr 
            340                 345                 350


Ala Ala Gly Val His Ser Val Leu Ser Ser Gln Phe Leu Ala Leu Cys 
        355                 360                 365


Thr Leu Lys Pro Ser Leu Val Val Glu Leu Ala Arg Asp Leu Leu Glu 
    370                 375                 380


Phe Leu Gly Ser Val Asn Gly Leu Cys Ser Arg Ala Ser Leu Val Thr 
385                 390                 395                 400


Ser Val Val Ser Pro Pro Gly Gly His Arg Ala Asp Asp His Ala Asp 
                405                 410                 415


Glu Ala Gly Leu Pro Glu Pro Arg Ser Asp Pro Gln Gly Leu Phe Ile 
            420                 425                 430


Ala Val Lys Asp Glu Asp Pro Gly Ser Gln Ser Ser His Gln Leu His 
        435                 440                 445


Ala Gln Arg Gly Gly Arg Gly Ser His Pro Tyr Pro Gly His Arg Ala 
    450                 455                 460


Ala Asp Pro Ala Glu Asp Ala 
465                 470


<210>  3554
<211>  3705
<212>  DNA
<213>  Homo sapiens

<400>  3554
cccggaagtt gaccggggtg cggagctcct gggctgcagc tcctggagtt tccgaggttc     60

gtgcgcgtct ggtggcggcg gcgtgatgtt ctcggcagga gcggagagtt tgctccacca    120

ggccagggag atccaggacg aggagctgaa gaagttctgt tcccggatct gtaaactgct    180

gcaggcggag gacttggggc cggacaccct cgactccctg cagaggctct tcctcatcat    240

ctcagccacg aagtacagcc ggaggctgga gaagacatgc gtagacctgc tgcaggccac    300

cctcggcctg cctgcatgcc ccgagcagct ccaggtgctt tgcgccgcca tcctgcgaga    360

gatgtccccc tctgacagcc tcagcctggc ctgggaccac acgcagaaca gccggcagct    420

gagcctggtg gcctccgttc tcttggccca gggtgacaga aacgaggagg tcagagccgt    480

gggccagggc gtgctacgag cgctggagag ccggcagcct gagggaccca gcctcagaca    540

cctcctcccc gtcatggcca agaccaggcc accctgctca gcaagcggct ggtcgactgg    600

ctgcgctacg ccagcctcca gcaagggctc ccacactccg gcggcttctt ctccacgccc    660

agggcccggc agccgggccc cgtcaccgag gtggacgggg cggtagccac agacttcttc    720

acggtgctct ccagcggcca ccgcttcaca gacgaccagt ggctgaacgt gcaggccttc    780

tctatgctgc gggcgtggct gctgcacagc ggccccgagg gcccgggcac cctggacaca    840

gatgacaggt cagagcagga gggctccact ctgtcggtga tctccgccac ctcctctgcc    900

ggccgcctgc tgccgccccg ggagcggctt cgggaggtgg ccttcgagta ctgccagcgc    960

ctcattgagc aaagtaaccg acgagccctg aggaaggggg actccgacct gcagaaagct   1020

tgcctggtgg aggccgtgct ggtgctggac gtgctgtgcc ggcaggaccc gtccttcctg   1080

taccgaagtc tctcctgcct gaaggccctg cacgggcggg tgcgcgggga cccggcctct   1140

gtgcgggtgc tgctgcccct cgcccacttc ttcctgagcc acggggaagc ggctgcagtg   1200

gactcggaag ccgtctacca gcacctgttc accaggatcc cggtggagca gttccacagc   1260

cccatgctgg cctttgaatt catccagttc tgcagggaca acctccacct gttcagcggg   1320

cacctcagca ccctcagatt gagcttcccc aacctcttta agttcctggc ctggaacagc   1380

ccacccctca cctccgagtt tgtggcgctc ctcccggccc tggtggacgc tggcacagcc   1440

ctggagatgc tgcacgcgct gctggacctg ccctgcttga cggcggtgct ggacctgcag   1500

ctcaggtcag caccggctgc atccgagagg ccactctggg acacctctct cagggccccc   1560

agctgcctgg aggccttccg ggacccgcag ttccagggtc ttttccaata cctgctgcgc   1620

cccaaggcca gtggcgccac tgagaggttg gcgccactcc accagctgct gcagcccatg   1680

gccggctgtg cccgcgtggc ccagtgtgcc caggccgtgc ccacgctgct gcaggcattc   1740

ttctcagcag tgacccaggt ggctgacggg tccctgatca accagctggc gctgctgctc   1800

ctgggcagga gcgactcgct ctacccggcc ccagggtacg ctgccggtgt gcacaggccc   1860

ttggcctgga tggggatggg gtcataggtc tgcacagagc aggcgtagac ccggctttct   1920

gggcagtgtg ctgagttctc agttcctggc cctgtgtacg ctgaaaccct ccctggtggt   1980

ggagctggca agagacctgc tggagttcct gggcagcgtg aatggtctct gcagcagggc   2040

gagcctcgtc accagcgtgg tgtgggccat cggcgagtac ctgtcggtga cctacgatcg   2100

gaggtgcacc gtggagcaga tcaacaagtt cttcgaagcc ctggaggctc tgctattcga   2160

ggtcacccag tgccgcccct ctgctgccct gcccaggtgt cccccccagg tggtcaccgt   2220

gctgatgacc acgctgacga agctggcctc ccggagccaa gatctgatcc ccagggcctc   2280

tttattgctg tcaaagatga ggaccctggc tcacagtcca gccaccagct ccacgcacag   2340

cgaggagggc gcggaagcca tccgtacccg ggccacagag ctgctgaccc tgctgaagat   2400

gcctagcgtg gcccagtttg tgctcacacc cagcacggag gtgtgcagcc cccgctatca   2460

ccgcgatgcc aacacggccc tgcccctggc cctgcgcacg gtcagccggc tggtggagag   2520

ggaggccggc ctcatgccag ggtgaaggga cagtggccag ggacttcggt gcagattaag   2580

agcctgggca gccagcttgc tactgaggcc aggctgatag gagctcagga gggcgcggga   2640

gtcctgggag aggaggcaag gcccacggtg ggcttggcac cctcacagac acgcggggct   2700

ggcccccctg ctcaccctct gggctttgtc tccgagcctt ttgctcccag gcaacactga   2760

gctgagctga ggggtgccat ggagcggctc tgattggagg cttgaggccc tgtggctggg   2820

tcgggtggag gctgctgggt ctgtttccta gtcttttgtt tttggacagt tgatgggcaa   2880

gaagagctgc agtaaaagta aatctccttt aataagcgtc tgtatgaaga gtgcgcgatc   2940

agttccgtta cctgccctgc accctgggga gaggaccagg gatgggaacc cctggcagct   3000

gctgccagtc ctggaggctc agcccggcgt gccactgctg ctacagaaac caggtcattt   3060

gtgcacagcc cggaaggcag cggcgcgagt tcccgggtgt ggtcaccgct ctgggtggtg   3120

cgcttgtcaa tgcccctttt gatgcccttg aatagcctga agatgaaggg gaccggggga   3180

gggttgcaag cgccatggcc tatgcaggct gcggcctctg gccattcgga gggaaggccc   3240

cagggagcca cctgagtgga gctcagaaca ctggattcgc gcgaagggga ggtgtctggg   3300

cgtgcggccc cagccccgcc accttcctgg gccctgtggt cccaccctcc ggactaccaa   3360

ggcacagctg tgtcgcacgt tccgcccggt gcctgggacg ggctcagccg ccagggggcg   3420

ccgccgcccc gagagcctca cgccccgccc ccaggctcaa actcttcccc ctccccactc   3480

tggctccgcc cccggtctcc tcttttgctc tggccccgcc cacctcccct ccggcctcgg   3540

ccccgccccc aatcccccat agctctgcga ctaagaaacc acaggctgaa ggcgactgca   3600

gggtcctgcc ccttgcccag cctcaggact atggaggggg cgagtgacgc gcaaggaacg   3660

gagcagggga caccgtgcgg gctcaggagc tccccagatg cccga                   3705


<210>  3555
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  3555

Met Leu Arg Ala Trp Leu Leu His Ser Gly Pro Glu Gly Pro Gly Thr 
1               5                   10                  15


Leu Asp Thr Asp Asp Arg Ser Glu Gln Glu Gly Ser Thr Leu Ser Val 
            20                  25                  30


Ile Ser Ala Thr Ser Ser Ala Gly Arg Leu Leu Pro Pro Arg Glu Arg 
        35                  40                  45


Leu Arg Glu Val Ala Phe Glu Tyr Cys Gln Arg Leu Ile Glu Gln Ser 
    50                  55                  60


Asn Arg Arg Ala Leu Arg Lys Gly Asp Ser Asp Leu Gln Lys Ala Cys 
65                  70                  75                  80


Leu Val Glu Ala Val Leu Val Leu Asp Val Leu Cys Arg Gln Asp Pro 
                85                  90                  95


Ser Phe Leu Tyr Arg Ser Leu Ser Cys Leu Lys Ala Leu His Gly Arg 
            100                 105                 110


Val Arg Gly Asp Pro Ala Ser Val Arg Val Leu Leu Pro Leu Ala His 
        115                 120                 125


Phe Phe Leu Ser His Gly Glu Ala Ala Ala Val Asp Ser Glu Ala Val 
    130                 135                 140


Tyr Gln His Leu Phe Thr Arg Ile Pro Val Glu Gln Phe His Ser Pro 
145                 150                 155                 160


Met Leu Ala Phe Glu Phe Ile Gln Phe Cys Arg Asp Asn Leu His Leu 
                165                 170                 175


Phe Ser Gly His Leu Ser Thr Leu Arg Leu Ser Phe Pro Asn Leu Phe 
            180                 185                 190


Lys Phe Leu Ala Trp Asn Ser Pro Pro Leu Thr Ser Glu Phe Val Ala 
        195                 200                 205


Leu Leu Pro Ala Leu Val Asp Ala Gly Thr Ala Leu Glu Met Leu His 
    210                 215                 220


Ala Leu Leu Asp Leu Pro Cys Leu Thr Ala Val Leu Asp Leu Gln Leu 
225                 230                 235                 240


Arg Ser Ala Pro Ala Ala Ser Glu Arg Pro Leu Trp Asp Thr Ser Leu 
                245                 250                 255


Arg Ala Pro Ser Cys Leu Glu Ala Phe Arg Asp Pro Gln Phe Gln Gly 
            260                 265                 270


Leu Phe Gln Tyr Leu Leu Arg Pro Lys Ala Ser Gly Ala Thr Glu Arg 
        275                 280                 285


Leu Ala Pro Leu His Gln Leu Leu Gln Pro Met Ala Gly Cys Ala Arg 
    290                 295                 300


Val Ala Gln Cys Ala Gln Ala Val Pro Thr Leu Leu Gln Ala Phe Phe 
305                 310                 315                 320


Ser Ala Val Thr Gln Val Ala Asp Gly Ser Leu Ile Asn Gln Leu Ala 
                325                 330                 335


Leu Leu Leu Leu Gly Arg Ser Asp Ser Leu Tyr Pro Ala Pro Gly Tyr 
            340                 345                 350


Ala Ala Gly Val His Arg Pro Leu Ala Trp Met Gly Met Gly Ser 
        355                 360                 365


<210>  3556
<211>  5764
<212>  DNA
<213>  Homo sapiens

<400>  3556
cccggaagtt gaccggggtg cggagctcct gggctgcagc tcctggagtt tccgaggttc     60

gtgcgcgtct ggtggcggcg gcgtgatgtt ctcggcagga gcggagagtt tgctccacca    120

ggccagggag atccaggacg aggagctgaa gaagttctgt tcccggatct gtaaactgct    180

gcaggcggag gacttggggc cggacaccct cgactccctg cagaggctct tcctcatcat    240

ctcagccacg aagtacagcc ggaggctgga gaagacatgc gtagacctgc tgcaggccac    300

cctcggcctg cctgcatgcc ccgagcagct ccaggtgctt tgcgccgcca tcctgcgaga    360

gatgtccccc tctgacagcc tcagcctggc ctgggaccac acgcagaaca gccggcagct    420

gagcctggtg gcctccgttc tcttggccca gggtgacaga aacgaggagg tcagagccgt    480

gggccagggc gtgctacgag cgctggagag ccggcagcct gagggaccca gcctcagaca    540

cctcctcccc gtcatggcca aggtcgtggt cctcagcccg ggcaccctcc aggaggacca    600

ggccaccctg ctcagcaagc ggctggtcga ctggctgcgc tacgccagcc tccagcaagg    660

gctcccacac tccggcggct tcttctccac gcccagggcc cggcagccgg gccccgtcac    720

cgaggtggac ggggcggtag ccacagactt cttcacggtg ctctccagcg gccaccgctt    780

cacagacgac cagtggctga acgtgcaggc cttctctatg ctgcgggcgt ggctgctgca    840

cagcggcccc gagggcccgg gcaccctgga cacagatgac aggtcagagc aggagggctc    900

cactctgtcg gtgatctccg ccacctcctc tgccggccgc ctgctgccgc cccgggagcg    960

gcttcgggag gtggccttcg agtactgcca gcgcctcatt gagcaaagta accgacgagc   1020

cctgaggaag ggggactccg acctgcagaa agcttgcctg gtggaggccg tgctggtgct   1080

ggacgtgctg tgccggcagg acccgtcctt cctgtaccga agtctctcct gcctgaaggc   1140

cctgcacggg cgggtgcgcg gggacccggc ctctgtgcgg gtgctgctgc ccctcgccca   1200

cttcttcctg agccacgggg aagcggctgc agtggactcg gaagccgtct accagcacct   1260

gttcaccagg atcccggtgg agcagttcca cagccccatg ctggcctttg aattcatcca   1320

gttctgcagg gacaacctcc acctgttcag cgggcacctc agcaccctca gattgagctt   1380

ccccaacctc tttaagttcc tggcctggaa cagcccaccc ctcacctccg agtttgtggc   1440

gctcctcccg gccctggtgg acgctggcac agccctggag atgctgcacg cgctgctgga   1500

cctgccctgc ttgacggcgg tgctggacct gcagctcagg tcagcaccgg ctgcatccga   1560

gaggccactc tgggacacct ctctcagggc ccccagctgc ctggaggcct tccgggaccc   1620

gcagttccag ggtcttttcc aatacctgct gcgccccaag gccagtggcg ccactgagag   1680

gttggcgcca ctccaccagc tgctgcagcc catggccggc tgtgcccgcg tggcccagtg   1740

tgcccaggcc gtgcccacgc tgctgcaggc attcttctca gcagtgaccc aggtggctga   1800

cgggtccctg atcaaccagc tggcgctgct gctcctgggc aggagcgact cgctctaccc   1860

ggccccaggg tacgctgccg gtgtgcacag gcctgatgca tgcaggccca tcctggttcc   1920

actctgagcc tgggcctgag gccagcgctg gtgccagcct tctccccagt gagaacagtt   1980

tctctgaggc tggcagtctt ctgtgttcct ctatcggagg gtgcagcata cacctaccac   2040

tcagacgctt cccgggtttc tccaggccct tggcctggat ggggatgggg tcataggtct   2100

gcacagagca ggcgtagacc cggctttctg ggcagtgtgc tgagttctca gttcctggcc   2160

ctgtgtacgc tgaaaccctc cctggtggtg gagctggcaa gagacctgct ggagttcctg   2220

ggcagcgtga atggtctctg cagcagggcg agcctcgtca ccagcgtggt gtgggccatc   2280

ggcgagtacc tgtcggtgac ctacgatcgg aggtgcaccg tggagcagat caacaagttc   2340

ttcgaagccc tggaggctct gctattcgag gtcacccagt gccgcccctc tgctgccctg   2400

cccaggtgtc ccccccaggt ggtcaccgtg ctgatgacca cgctgacgaa gctggcctcc   2460

cggagccaag atctgatccc cagggcctct ttattgctgt caaagatgag gaccctggct   2520

cacagtccag ccaccagctc cacgcacagc gaggagggcg cggaagccat ccgtacccgg   2580

gccacagagc tgctgaccct gctgaagatg cctagcgtgg cccagtttgt gctcacaccc   2640

agcacggagg tgtgcagccc ccgctatcac cgcgatgcca acacggccct gcccctggcc   2700

ctgcgcacgg tcagccggct ggtggagagg gaggccggcc tcatgccagg gtgaagggac   2760

agtggccagg gacttcggtg cagattaaga gcctgggcag ccagcttgct actgaggcca   2820

ggctgatagg agctcaggag ggcgcgggag tcctgggaga ggaggcaagg cccacggtgg   2880

gcttggcacc ctcacagaca cgcggggctg gcccccctgc tcaccctctg ggctttgtct   2940

ccgagccttt tgctcccagg caacactgag ctgagctgag gggtgccatg gagcggctct   3000

gattggaggc ttgaggccct gtggctgggt cgggtggagg ctgctgggtc tgtttcctag   3060

tcttttgttt ttggacagtt gatgggcaag aagagctgca gtaaaagtaa atctccttta   3120

ataagcgtct gtatgaagag tgcgcgatca gttccgttac ctgccctgca ccctggggag   3180

aggaccaggg atgggaaccc ctggcagctg ctgccagtcc tggaggctca gcccggcgtg   3240

ccactgctgc tacagaaacc aggtcatttg tgcacagccc ggaaggcagc ggcgcgagtt   3300

cccgggtgtg gtcaccgctc tgggtggtgc gcttgtcaat gccccttttg atgcccttga   3360

atagcctgaa gatgaagggg accgggggag ggttgcaagc gccatggcct atgcaggctg   3420

cggcctctgg ccattcggag ggaaggcccc agggagccac ctgagtggag ctcagaacac   3480

tggattcgcg cgaaggggag gtgtctgggc gtgcggcccc agccccgcca ccttcctggg   3540

ccctgtggtc ccaccctccg gactaccaag gcacagctgt gtcgcacgtt ccgcccggtg   3600

cctgggacgg gctcagccgc cagggggcgc cgccgccccg agagcctcac gccccgcccc   3660

caggctcaaa ctcttccccc tccccactct ggctccgccc ccggtctcct cttttgctct   3720

ggccccgccc acctcccctc cggcctcggc cccgccccca atcccccata gctctgcgac   3780

taagaaacca caggctgaag gcgactgcag ggtcctgccc cttgcccagc ctcaggacta   3840

tggagggggc gagtgacgcg caaggaacgg agcaggggac accgtgcggg ctcaggagct   3900

ccccagatgc ccgagccgaa ccgcggggtc ctcaccgcca ggttccagcc caggaagcgc   3960

tcgcctgccc cacagcctgg gccttgggtc gcgttccgag ctccaggacg gctggtgtcc   4020

cccgcggcct gcgatgacag cccagggccg ctgagccggg gccgcaggaa aggctggcgc   4080

tggcaggcgc ttccgtcggc agcactgtgt ttgtgtttcc acgtggaaac agcagcgcac   4140

gtgtacaact gtgcatacca aggcgtgcgt gccagtgcgc gggtctcggg atcacttccc   4200

agtgcggtgc acgaccccgc ctgcagcagt gggtgtgggg gcgctgctgg gctcatcccg   4260

aagctcagag agcgtggggc tgcccctagg ctcggaatga gtctcccact gagtccgcag   4320

ctcccctcct gccctggggc ggggcttccc tgacctgaag gcgtcggggg tgtcctggct   4380

cccagctccc aggcactcgt ggggccaccg cccaggccag ctggtgctaa gtccgcagcc   4440

tgtgcagcag cgcccggctt aggactggga gtgtgacttg aagggccgtc ccgctcatcc   4500

aagggacaag gaggagctca tggccacagg gcctcggagg gcatgacccc agcccaggga   4560

ggagcaacct tcaggtggcc tccaggaggc agctgggaaa agggcaaagc tcaccagctc   4620

tcaacttttt ttttaaataa actgaaattt tagaatagtt tttcagattt acagaaaaga   4680

tgataaacct tagaaacatt atatgctaag tgaaagtgag aagtgacagc ctgctggcag   4740

tcctcacagc cctcgctcgc tcttggcgcc tcctctgcct gggctcccac tttggcagca   4800

cttgaggagc ccttcagccc gccactgcac tgtgggagcc cctttcaggg ctggccaagg   4860

ccggagccgg ctccctcagc ttgcggggag gtgtggaggg agaggcgcgg tgggaaccag   4920

ggctgcacgc ggtgcttgcg ggccagcgcg agttccgggt gggcgtgggc tctgtgggcc   4980

ccgcactcgg agccgccggc tagccccgcc agcctgggca gtgaggggct tagcacctgg   5040

accagcagct gctgtgctcg atttctcact gggccttagc tgccttcctg cggggcaggg   5100

ctggggacct gcagcccgcc atgcctgagc ctcccccctc ccctccgtgg gttcctgcgc   5160

agtccgagcc tccccaacga gtgttgccac ctgctcaggg cacccagtcc catcgaccac   5220

ccaagggctg aggagtgcct ttggagcagg gcacgggact ggcaggcagc tctacctgca   5280

gcccctgtgc aggatccact gggtgaaagc cagctgggct cctgagtctg gtggggactt   5340

ggagaacctt tatgtctagc taagggattg taaataaacc aattggcact ctgtatctag   5400

ctcaaggttt gtaaacacac caatcagcac cttgtgtcta gctcagggtt tgtgaatgca   5460

ccaatagaca ctctgtatct agctactctg gtggggactt ggaaaacctt tttgtcaaca   5520

ctctgtatct agttaatctg gtggggacat ggagaacctt tgtgtctagc tcagggattg   5580

taaacgcacc aatcagcacc ctgtcaaaac agaccactcg gctctaccag tcagcaggat   5640

gtgggtgggg ccagatgaga ataaaagcag gctgcccgag ccagcagtga caacccactc   5700

gggtcccctt ccacaccggg atgctttgtt tgttcgctct ttgcaataaa tcttgctgct   5760

gctc                                                                5764


<210>  3557
<211>  613
<212>  PRT
<213>  Homo sapiens

<400>  3557

Met Phe Ser Ala Gly Ala Glu Ser Leu Leu His Gln Ala Arg Glu Ile 
1               5                   10                  15


Gln Asp Glu Glu Leu Lys Lys Phe Cys Ser Arg Ile Cys Lys Leu Leu 
            20                  25                  30


Gln Ala Glu Asp Leu Gly Pro Asp Thr Leu Asp Ser Leu Gln Arg Leu 
        35                  40                  45


Phe Leu Ile Ile Ser Ala Thr Lys Tyr Ser Arg Arg Leu Glu Lys Thr 
    50                  55                  60


Cys Val Asp Leu Leu Gln Ala Thr Leu Gly Leu Pro Ala Cys Pro Glu 
65                  70                  75                  80


Gln Leu Gln Val Leu Cys Ala Ala Ile Leu Arg Glu Met Ser Pro Ser 
                85                  90                  95


Asp Ser Leu Ser Leu Ala Trp Asp His Thr Gln Asn Ser Arg Gln Leu 
            100                 105                 110


Ser Leu Val Ala Ser Val Leu Leu Ala Gln Gly Asp Arg Asn Glu Glu 
        115                 120                 125


Val Arg Ala Val Gly Gln Gly Val Leu Arg Ala Leu Glu Ser Arg Gln 
    130                 135                 140


Pro Glu Gly Pro Ser Leu Arg His Leu Leu Pro Val Met Ala Lys Val 
145                 150                 155                 160


Val Val Leu Ser Pro Gly Thr Leu Gln Glu Asp Gln Ala Thr Leu Leu 
                165                 170                 175


Ser Lys Arg Leu Val Asp Trp Leu Arg Tyr Ala Ser Leu Gln Gln Gly 
            180                 185                 190


Leu Pro His Ser Gly Gly Phe Phe Ser Thr Pro Arg Ala Arg Gln Pro 
        195                 200                 205


Gly Pro Val Thr Glu Val Asp Gly Ala Val Ala Thr Asp Phe Phe Thr 
    210                 215                 220


Val Leu Ser Ser Gly His Arg Phe Thr Asp Asp Gln Trp Leu Asn Val 
225                 230                 235                 240


Gln Ala Phe Ser Met Leu Arg Ala Trp Leu Leu His Ser Gly Pro Glu 
                245                 250                 255


Gly Pro Gly Thr Leu Asp Thr Asp Asp Arg Ser Glu Gln Glu Gly Ser 
            260                 265                 270


Thr Leu Ser Val Ile Ser Ala Thr Ser Ser Ala Gly Arg Leu Leu Pro 
        275                 280                 285


Pro Arg Glu Arg Leu Arg Glu Val Ala Phe Glu Tyr Cys Gln Arg Leu 
    290                 295                 300


Ile Glu Gln Ser Asn Arg Arg Ala Leu Arg Lys Gly Asp Ser Asp Leu 
305                 310                 315                 320


Gln Lys Ala Cys Leu Val Glu Ala Val Leu Val Leu Asp Val Leu Cys 
                325                 330                 335


Arg Gln Asp Pro Ser Phe Leu Tyr Arg Ser Leu Ser Cys Leu Lys Ala 
            340                 345                 350


Leu His Gly Arg Val Arg Gly Asp Pro Ala Ser Val Arg Val Leu Leu 
        355                 360                 365


Pro Leu Ala His Phe Phe Leu Ser His Gly Glu Ala Ala Ala Val Asp 
    370                 375                 380


Ser Glu Ala Val Tyr Gln His Leu Phe Thr Arg Ile Pro Val Glu Gln 
385                 390                 395                 400


Phe His Ser Pro Met Leu Ala Phe Glu Phe Ile Gln Phe Cys Arg Asp 
                405                 410                 415


Asn Leu His Leu Phe Ser Gly His Leu Ser Thr Leu Arg Leu Ser Phe 
            420                 425                 430


Pro Asn Leu Phe Lys Phe Leu Ala Trp Asn Ser Pro Pro Leu Thr Ser 
        435                 440                 445


Glu Phe Val Ala Leu Leu Pro Ala Leu Val Asp Ala Gly Thr Ala Leu 
    450                 455                 460


Glu Met Leu His Ala Leu Leu Asp Leu Pro Cys Leu Thr Ala Val Leu 
465                 470                 475                 480


Asp Leu Gln Leu Arg Ser Ala Pro Ala Ala Ser Glu Arg Pro Leu Trp 
                485                 490                 495


Asp Thr Ser Leu Arg Ala Pro Ser Cys Leu Glu Ala Phe Arg Asp Pro 
            500                 505                 510


Gln Phe Gln Gly Leu Phe Gln Tyr Leu Leu Arg Pro Lys Ala Ser Gly 
        515                 520                 525


Ala Thr Glu Arg Leu Ala Pro Leu His Gln Leu Leu Gln Pro Met Ala 
    530                 535                 540


Gly Cys Ala Arg Val Ala Gln Cys Ala Gln Ala Val Pro Thr Leu Leu 
545                 550                 555                 560


Gln Ala Phe Phe Ser Ala Val Thr Gln Val Ala Asp Gly Ser Leu Ile 
                565                 570                 575


Asn Gln Leu Ala Leu Leu Leu Leu Gly Arg Ser Asp Ser Leu Tyr Pro 
            580                 585                 590


Ala Pro Gly Tyr Ala Ala Gly Val His Arg Pro Asp Ala Cys Arg Pro 
        595                 600                 605


Ile Leu Val Pro Leu 
    610


<210>  3558
<211>  3083
<212>  DNA
<213>  Homo sapiens

<400>  3558
cggaagttga ccggggtgcg gagctcctgg gctgcagctc ctggagtttc cgaggttcgt     60

gcgcgtctgg tggcggcggc gtgatgttct cggcaggagc ggagagtttg ctccaccagg    120

ccagggtgac agaaacgagg aggtcagagc cgtgggccag ggcgtgctac gagcgctgga    180

gagccggcag cctgagggac ccagcctcag acacctcctc cccgtcatgg ccaaggtcgt    240

ggtcctcagc ccgggcaccc tccaggagga ccaggccacc ctgctcagca agcggctggt    300

cgactggctg cgctacgcca gcctccagca agggctccca cactccggcg gcttcttctc    360

cacgcccagg gcccggcagc cgggccccgt caccgaggtg gacggggcgg tagccacaga    420

cttcttcacg gtgctctcca gcggccaccg cttcacagac gaccagtggc tgaacgtgca    480

ggccttctct atgctgcggg cgtggctgct gcacagcggc cccgagggcc cgggcaccct    540

ggacacagat gacaggtcag agcaggaggg ctccactctg tcggtgatct ccgccacctc    600

ctctgccggc cgcctgctgc cgccccggga gcggcttcgg gaggtggcct tcgagtactg    660

ccagcgcctc attgagcaaa gtaaccgacg agccctgagg aagggggact ccgacctgca    720

gaaagcttgc ctggtggagg ccgtgctggt gctggacgtg ctgtgccggc aggacccgtc    780

cttcctgtac cgaagtctct cctgcctgaa ggccctgcac gggcgggtgc gcggggaccc    840

ggcctctgtg cgggtgctgc tgcccctcgc ccacttcttc ctgagccacg gggaagcggc    900

tgcagtggac tcggaagccg tctaccagca cctgttcacc aggatcccgg tggagcagtt    960

ccacagcccc atgctggcct ttgaattcat ccagttctgc agggacaacc tccacctgtt   1020

cagcgggcac ctcagcaccc tcagattgag cttccccaac ctctttaagt tcctggcctg   1080

gaacagccca cccctcacct ccgagtttgt ggcgctcctc ccggccctgg tggacgctgg   1140

cacagccctg gagatgctgc acgcgctgct ggacctgccc tgcttgacgg cggtgctgga   1200

cctgcagctc aggtcagcac cggctgcatc cgagaggcca ctctgggaca cctctctcag   1260

ggcccccagc tgcctggagg ccttccggga cccgcagttc cagggtcttt tccaatacct   1320

gctgcgcccc aaggccagtg gcgccactga gaggttggcg ccactccacc agctgctgca   1380

gcccatggcc ggctgtgccc gcgtggccca gtgtgcccag gccgtgccca cgctgctgca   1440

ggcattcttc tcagcagtga cccaggtggc tgacgggtcc ctgatcaacc agctggcgct   1500

gctgctcctg ggcaggagcg actcgctcta cccggcccca gggtacgctg ccggtgtgca   1560

caggtaggtc cctcctgcgc tcctgccaca gccctgggcg ggtgcctcct ggactcctcc   1620

ccctctcccc tcccccctcc ccttcagtgg cttcggcacc acccctagct gggccctcag   1680

cagcctcaga ccctgccacc cccacccaca gccccacacc cagccccagg cacttctctc   1740

tgcttctcaa gaacattccc gtccttcttt ctgccgagcc tgtcctcttc agggttagct   1800

caggtccctc ttccccgtct tgtcccctgg ggtccttctc tccaaaggcc tgatgcatgc   1860

aggcccatcc tggttccact ctgagcctgg gcctgaggcc agcgctggtg ccagccttct   1920

ccccagtgag aacagtttct ctgaggctgg cagtcttctg tgttcctcta tcggagggtg   1980

cagcatacac ctaccactca gacgcttccc gggtttctcc aggcccttgg cctggatggg   2040

gatggggtca taggtctgca cagagcaggc gtagacccgg ctttctgggc agtgtgctga   2100

gttctcagtt cctggccctg tgtacgctga aaccctccct ggtggtggag ctggcaagag   2160

acctgctgga gttcctgggc agcgtgaatg gtctctgcag cagggcgagc ctcgtcacca   2220

gcgtggtgtg ggccatcggc gagtacctgt cggtgaccta cgatcggagg tgcaccgtgg   2280

agcagatcaa caagttcttc gaagccctgg aggctctgct attcgaggtc acccagtgcc   2340

gcccctctgc tgccctgccc aggtgtcccc cccaggtggt caccgtgctg atgaccacgc   2400

tgacgaagct ggcctcccgg agccaagatc tgatccccag ggcctcttta ttgctgtcaa   2460

agatgaggac cctggctcac agtccagcca ccagctccac gcacagcgag gagggcgcgg   2520

aagccatccg tacccgggcc acagagctgc tgaccctgct gaagatgcct agcgtggccc   2580

agtttgtgct cacacccagc acggaggtgt gcagcccccg ctatcaccgc gatgccaaca   2640

cggccctgcc cctggccctg cgcacggtca gccggctggt ggagagggag gccggcctca   2700

tgccagggtg aagggacagt ggccagggac ttcggtgcag attaagagcc tgggcagcca   2760

gcttgctact gaggccaggc tgataggagc tcaggagggc gcgggagtcc tgggagagga   2820

ggcaaggccc acggtgggct tggcaccctc acagacacgc ggggctggcc cccctgctca   2880

ccctctgggc tttgtctccg agccttttgc tcccaggcaa cactgagctg agctgagggg   2940

tgccatggag cggctctgat tggaggcttg aggccctgtg gctgggtcgg gtggaggctg   3000

ctgggtctgt ttcctagtct tttgtttttg gacagttgat gggcaagaag agctgcagta   3060

aaagtaaatc tcctttaata agc                                           3083


<210>  3559
<211>  446
<212>  PRT
<213>  Homo sapiens

<400>  3559

Met Ala Lys Val Val Val Leu Ser Pro Gly Thr Leu Gln Glu Asp Gln 
1               5                   10                  15


Ala Thr Leu Leu Ser Lys Arg Leu Val Asp Trp Leu Arg Tyr Ala Ser 
            20                  25                  30


Leu Gln Gln Gly Leu Pro His Ser Gly Gly Phe Phe Ser Thr Pro Arg 
        35                  40                  45


Ala Arg Gln Pro Gly Pro Val Thr Glu Val Asp Gly Ala Val Ala Thr 
    50                  55                  60


Asp Phe Phe Thr Val Leu Ser Ser Gly His Arg Phe Thr Asp Asp Gln 
65                  70                  75                  80


Trp Leu Asn Val Gln Ala Phe Ser Met Leu Arg Ala Trp Leu Leu His 
                85                  90                  95


Ser Gly Pro Glu Gly Pro Gly Thr Leu Asp Thr Asp Asp Arg Ser Glu 
            100                 105                 110


Gln Glu Gly Ser Thr Leu Ser Val Ile Ser Ala Thr Ser Ser Ala Gly 
        115                 120                 125


Arg Leu Leu Pro Pro Arg Glu Arg Leu Arg Glu Val Ala Phe Glu Tyr 
    130                 135                 140


Cys Gln Arg Leu Ile Glu Gln Ser Asn Arg Arg Ala Leu Arg Lys Gly 
145                 150                 155                 160


Asp Ser Asp Leu Gln Lys Ala Cys Leu Val Glu Ala Val Leu Val Leu 
                165                 170                 175


Asp Val Leu Cys Arg Gln Asp Pro Ser Phe Leu Tyr Arg Ser Leu Ser 
            180                 185                 190


Cys Leu Lys Ala Leu His Gly Arg Val Arg Gly Asp Pro Ala Ser Val 
        195                 200                 205


Arg Val Leu Leu Pro Leu Ala His Phe Phe Leu Ser His Gly Glu Ala 
    210                 215                 220


Ala Ala Val Asp Ser Glu Ala Val Tyr Gln His Leu Phe Thr Arg Ile 
225                 230                 235                 240


Pro Val Glu Gln Phe His Ser Pro Met Leu Ala Phe Glu Phe Ile Gln 
                245                 250                 255


Phe Cys Arg Asp Asn Leu His Leu Phe Ser Gly His Leu Ser Thr Leu 
            260                 265                 270


Arg Leu Ser Phe Pro Asn Leu Phe Lys Phe Leu Ala Trp Asn Ser Pro 
        275                 280                 285


Pro Leu Thr Ser Glu Phe Val Ala Leu Leu Pro Ala Leu Val Asp Ala 
    290                 295                 300


Gly Thr Ala Leu Glu Met Leu His Ala Leu Leu Asp Leu Pro Cys Leu 
305                 310                 315                 320


Thr Ala Val Leu Asp Leu Gln Leu Arg Ser Ala Pro Ala Ala Ser Glu 
                325                 330                 335


Arg Pro Leu Trp Asp Thr Ser Leu Arg Ala Pro Ser Cys Leu Glu Ala 
            340                 345                 350


Phe Arg Asp Pro Gln Phe Gln Gly Leu Phe Gln Tyr Leu Leu Arg Pro 
        355                 360                 365


Lys Ala Ser Gly Ala Thr Glu Arg Leu Ala Pro Leu His Gln Leu Leu 
    370                 375                 380


Gln Pro Met Ala Gly Cys Ala Arg Val Ala Gln Cys Ala Gln Ala Val 
385                 390                 395                 400


Pro Thr Leu Leu Gln Ala Phe Phe Ser Ala Val Thr Gln Val Ala Asp 
                405                 410                 415


Gly Ser Leu Ile Asn Gln Leu Ala Leu Leu Leu Leu Gly Arg Ser Asp 
            420                 425                 430


Ser Leu Tyr Pro Ala Pro Gly Tyr Ala Ala Gly Val His Arg 
        435                 440                 445


<210>  3560
<211>  3342
<212>  DNA
<213>  Homo sapiens

<400>  3560
cggaagttga ccggggtgcg gagctcctgg gctgcagctc ctggagtttc cgaggttcgt     60

gcgcgtctgg tggcggcggc gtgatgttct cggcaggagc ggagagtttg ctccaccagg    120

ccagggtgac agaaacgagg aggtcagagc cgtgggccag ggcgtgctac gagcgctgga    180

gagccggcag cctgagggac ccagcctcag acacctcctc cccgtcatgg ccaaggtcgt    240

ggtcctcagc ccgggcaccc tccaggagga ccaggccacc ctgctcagca agcggctggt    300

cgactggctg cgctacgcca gcctccagca agggctccca cactccggcg gcttcttctc    360

cacgcccagg gcccggcagc cgggccccgt caccgaggtg gacggggcgg tagccacaga    420

cttcttcacg gtgctctcca gcggccaccg cttcacagac gaccagtggc tgaacgtgca    480

ggccttctct atgctgcggg cgtggctgct gcacagcggc cccgagggcc cgggcaccct    540

ggacacagat gacaggtcag agcaggaggg ctccactctg tcggtgatct ccgccacctc    600

ctctgccggc cgcctgctgc cgccccggga gcggcttcgg gaggtggcct tcgagtactg    660

ccagcgcctc attgagcaaa gtaaccgacg agccctgagg aagggggact ccgacctgca    720

gaaagcttgc ctggtggagg ccgtgctggt gctggacgtg ctgtgccggc aggacccgtc    780

cttcctgtac cgaagtctct cctgcctgaa ggccctgcac gggcgggtgc gcggggaccc    840

ggcctctgtg cgggtgctgc tgcccctcgc ccacttcttc ctgagccacg gggaagcggc    900

tgcagtggac tcggaagccg tctaccagca cctgttcacc aggatcccgg tggagcagtt    960

ccacagcccc atgctggcct ttgaattcat ccagttctgc agggacaacc tccacctgtt   1020

cagcgggcac ctcagcaccc tcagattgag cttccccaac ctctttaagt tcctggcctg   1080

gaacagccca cccctcacct ccgagtttgt ggcgctcctc ccggccctgg tggacgctgg   1140

cacagccctg gagatgctgc acgcgctgct ggacctgccc tgcttgacgg cggtgctgga   1200

cctgcagctc aggtcagcac cggctgcatc cgagaggcca ctctgggaca cctctctcag   1260

ggcccccagc tgcctggagg ccttccggga cccgcagttc cagggtcttt tccaatacct   1320

gctgcgcccc aaggccagtg gcgccactga gaggttggcg ccactccacc agctgctgca   1380

gcccatggcc ggctgtgccc gcgtggccca gtgtgcccag gccgtgccca cgctgctgca   1440

ggcattcttc tcagcagtga cccaggtggc tgacgggtcc ctgatcaacc agctggcgct   1500

gctgctcctg ggcaggagcg actcgctcta cccggcccca gggtacgctg ccggtgtgca   1560

cagtgtgctg agttctcagt tcctggccct gtgtacgctg aaaccctccc tggtggtgga   1620

gctggcaaga gacctgctgg agttcctggg cagcgtgaat ggtctctgca gcagggcgag   1680

cctcgtcacc agcgtggtgt gggccatcgg cgagtacctg tcggtgacct acgatcggag   1740

gtgcaccgtg gagcagatca acaagttctt cgaagccctg gaggctctgc tattcgaggt   1800

cacccagtgc cgcccctctg ctgccctgcc caggtgtccc ccccaggtgg tcaccgtgct   1860

gatgaccacg ctgacgaagc tggcctcccg gagccaagat ctgatcccca gggcctcttt   1920

attgctgtca aagatgagga ccctggctca cagtccagcc accagctcca cgcacagcga   1980

ggagggcgcg gaagccatcc gtacccgggc cacagagctg ctgaccctgc tgaagatgcc   2040

tagcgtggcc cagtttgtgc tcacacccag cacggaggtg tgcagccccc gctatcaccg   2100

cgatgccaac acggccctgc ccctggccct gcgcacggtc agccggctgg tggagaggga   2160

ggccggcctc atgccagggt gaagggacag tggccaggga cttcggtgca gattaagagc   2220

ctgggcagcc agcttgctac tgaggccagg ctgataggag ctcaggaggg cgcgggagtc   2280

ctgggagagg aggcaaggcc cacggtgggc ttggcaccct cacagacacg cggggctggc   2340

ccccctgctc accctctggg ctttgtctcc gagccttttg ctcccaggca acactgagct   2400

gagctgaggg gtgccatgga gcggctctga ttggaggctt gaggccctgt ggctgggtcg   2460

ggtggaggct gctgggtctg tttcctagtc ttttgttttt ggacagttga tgggcaagaa   2520

gagctgcagt aaaagtaaat ctcctttaat aagcgtctgt atgaagagtg cgcgatcagt   2580

tccgttacct gccctgcacc ctggggagag gaccagggat gggaacccct ggcagctgct   2640

gccagtcctg gaggctcagc ccggcgtgcc actgctgcta cagaaaccag gtcatttgtg   2700

cacagcccgg aaggcagcgg cgcgagttcc cgggtgtggt caccgctctg ggtggtgcgc   2760

ttgtcaatgc cccttttgat gcccttgaat agcctgaaga tgaaggggac cgggggaggg   2820

ttgcaagcgc catggcctat gcaggctgcg gcctctggcc attcggaggg aaggccccag   2880

ggagccacct gagtggagct cagaacactg gattcgcgcg aaggggaggt gtctgggcgt   2940

gcggccccag ccccgccacc ttcctgggcc ctgtggtccc accctccgga ctaccaaggc   3000

acagctgtgt cgcacgttcc gcccggtgcc tgggacgggc tcagccgcca gggggcgccg   3060

ccgccccgag agcctcacgc cccgccccca ggctcaaact cttccccctc cccactctgg   3120

ctccgccccc ggtctcctct tttgctctgg ccccgcccac ctcccctccg gcctcggccc   3180

cgcccccaat cccccatagc tctgcgacta agaaaccaca ggctgaaggc gactgcaggg   3240

tcctgcccct tgcccagcct caggactatg gagggggcga gtgacgcgca aggaacggag   3300

caggggacac cgtgcgggct caggagctcc ccagatgccc ga                      3342


<210>  3561
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  3561

Met Ala Lys Val Val Val Leu Ser Pro Gly Thr Leu Gln Glu Asp Gln 
1               5                   10                  15


Ala Thr Leu Leu Ser Lys Arg Leu Val Asp Trp Leu Arg Tyr Ala Ser 
            20                  25                  30


Leu Gln Gln Gly Leu Pro His Ser Gly Gly Phe Phe Ser Thr Pro Arg 
        35                  40                  45


Ala Arg Gln Pro Gly Pro Val Thr Glu Val Asp Gly Ala Val Ala Thr 
    50                  55                  60


Asp Phe Phe Thr Val Leu Ser Ser Gly His Arg Phe Thr Asp Asp Gln 
65                  70                  75                  80


Trp Leu Asn Val Gln Ala Phe Ser Met Leu Arg Ala Trp Leu Leu His 
                85                  90                  95


Ser Gly Pro Glu Gly Pro Gly Thr Leu Asp Thr Asp Asp Arg Ser Glu 
            100                 105                 110


Gln Glu Gly Ser Thr Leu Ser Val Ile Ser Ala Thr Ser Ser Ala Gly 
        115                 120                 125


Arg Leu Leu Pro Pro Arg Glu Arg Leu Arg Glu Val Ala Phe Glu Tyr 
    130                 135                 140


Cys Gln Arg Leu Ile Glu Gln Ser Asn Arg Arg Ala Leu Arg Lys Gly 
145                 150                 155                 160


Asp Ser Asp Leu Gln Lys Ala Cys Leu Val Glu Ala Val Leu Val Leu 
                165                 170                 175


Asp Val Leu Cys Arg Gln Asp Pro Ser Phe Leu Tyr Arg Ser Leu Ser 
            180                 185                 190


Cys Leu Lys Ala Leu His Gly Arg Val Arg Gly Asp Pro Ala Ser Val 
        195                 200                 205


Arg Val Leu Leu Pro Leu Ala His Phe Phe Leu Ser His Gly Glu Ala 
    210                 215                 220


Ala Ala Val Asp Ser Glu Ala Val Tyr Gln His Leu Phe Thr Arg Ile 
225                 230                 235                 240


Pro Val Glu Gln Phe His Ser Pro Met Leu Ala Phe Glu Phe Ile Gln 
                245                 250                 255


Phe Cys Arg Asp Asn Leu His Leu Phe Ser Gly His Leu Ser Thr Leu 
            260                 265                 270


Arg Leu Ser Phe Pro Asn Leu Phe Lys Phe Leu Ala Trp Asn Ser Pro 
        275                 280                 285


Pro Leu Thr Ser Glu Phe Val Ala Leu Leu Pro Ala Leu Val Asp Ala 
    290                 295                 300


Gly Thr Ala Leu Glu Met Leu His Ala Leu Leu Asp Leu Pro Cys Leu 
305                 310                 315                 320


Thr Ala Val Leu Asp Leu Gln Leu Arg Ser Ala Pro Ala Ala Ser Glu 
                325                 330                 335


Arg Pro Leu Trp Asp Thr Ser Leu Arg Ala Pro Ser Cys Leu Glu Ala 
            340                 345                 350


Phe Arg Asp Pro Gln Phe Gln Gly Leu Phe Gln Tyr Leu Leu Arg Pro 
        355                 360                 365


Lys Ala Ser Gly Ala Thr Glu Arg Leu Ala Pro Leu His Gln Leu Leu 
    370                 375                 380


Gln Pro Met Ala Gly Cys Ala Arg Val Ala Gln Cys Ala Gln Ala Val 
385                 390                 395                 400


Pro Thr Leu Leu Gln Ala Phe Phe Ser Ala Val Thr Gln Val Ala Asp 
                405                 410                 415


Gly Ser Leu Ile Asn Gln Leu Ala Leu Leu Leu Leu Gly Arg Ser Asp 
            420                 425                 430


Ser Leu Tyr Pro Ala Pro Gly Tyr Ala Ala Gly Val His Ser Val Leu 
        435                 440                 445


Ser Ser Gln Phe Leu Ala Leu Cys Thr Leu Lys Pro Ser Leu Val Val 
    450                 455                 460


Glu Leu Ala Arg Asp Leu Leu Glu Phe Leu Gly Ser Val Asn Gly Leu 
465                 470                 475                 480


Cys Ser Arg Ala Ser Leu Val Thr Ser Val Val Trp Ala Ile Gly Glu 
                485                 490                 495


Tyr Leu Ser Val Thr Tyr Asp Arg Arg Cys Thr Val Glu Gln Ile Asn 
            500                 505                 510


Lys Phe Phe Glu Ala Leu Glu Ala Leu Leu Phe Glu Val Thr Gln Cys 
        515                 520                 525


Arg Pro Ser Ala Ala Leu Pro Arg Cys Pro Pro Gln Val Val Thr Val 
    530                 535                 540


Leu Met Thr Thr Leu Thr Lys Leu Ala Ser Arg Ser Gln Asp Leu Ile 
545                 550                 555                 560


Pro Arg Ala Ser Leu Leu Leu Ser Lys Met Arg Thr Leu Ala His Ser 
                565                 570                 575


Pro Ala Thr Ser Ser Thr His Ser Glu Glu Gly Ala Glu Ala Ile Arg 
            580                 585                 590


Thr Arg Ala Thr Glu Leu Leu Thr Leu Leu Lys Met Pro Ser Val Ala 
        595                 600                 605


Gln Phe Val Leu Thr Pro Ser Thr Glu Val Cys Ser Pro Arg Tyr His 
    610                 615                 620


Arg Asp Ala Asn Thr Ala Leu Pro Leu Ala Leu Arg Thr Val Ser Arg 
625                 630                 635                 640


Leu Val Glu Arg Glu Ala Gly Leu Met Pro Gly 
                645                 650


<210>  3562
<211>  3871
<212>  DNA
<213>  Homo sapiens

<400>  3562
cggaagttga ccggggtgcg gagctcctgg gctgcagctc ctggagtttc cgaggttcgt     60

gcgcgtctgg tggcggcggc gtgatgttct cggcaggagc ggagagtttg ctccaccagg    120

ccagggtgac agaaacgagg aggtcagagc cgtgggccag ggcgtgctac gagcgctgga    180

gagccggcag cctgagggac ccagcctcag acacctcctc cccgtcatgg ccaaggtcgt    240

ggtcctcagc ccgggcaccc tccaggagga ccaggccacc ctgctcagca agcggctggt    300

cgactggctg cgctacgcca gcctccagca agggctccca cactccggcg gcttcttctc    360

cacgcccagg gcccggcagc cgggccccgt caccgaggtg gacggggcgg tagccacaga    420

cttcttcacg gtgctctcca gcggccaccg cttcacagac gaccagtggc tgaacgtgca    480

ggccttctct atgctgcggg cgtggctgct gcacagcggc cccgagggcc cgggcaccct    540

ggacacagat gacaggtcag agcaggaggg ctccactctg tcggtgatct ccgccacctc    600

ctctgccggc cgcctgctgc cgccccggga gcggcttcgg gaggtggcct tcgagtactg    660

ccagcgcctc attgagcaaa gtaaccgacg agccctgagg aagggggact ccgacctgca    720

gaaagcttgc ctggtggagg ccgtgctggt gctggacgtg ctgtgccggc aggacccgtc    780

cttcctgtac cgaagtctct cctgcctgaa ggccctgcac gggcgggtgc gcggggaccc    840

ggcctctgtg cgggtgctgc tgcccctcgc ccacttcttc ctgagccacg gggaagcggc    900

tgcagtggac tcggaagccg tctaccagca cctgttcacc aggatcccgg tggagcagtt    960

ccacagcccc atgctggcct ttgaattcat ccagttctgc agggacaacc tccacctgtt   1020

cagcgggcac ctcagcaccc tcagattgag cttccccaac ctctttaagt tcctggcctg   1080

gaacagccca cccctcacct ccgagtttgt ggcgctcctc ccggccctgg tggacgctgg   1140

cacagccctg gagatgctgc acgcgctgct ggacctgccc tgcttgacgg cggtgctgga   1200

cctgcagctc aggtcagcac cggctgcatc cgagaggcca ctctgggaca cctctctcag   1260

ggcccccagc tgcctggagg ccttccggga cccgcagttc cagggtcttt tccaatacct   1320

gctgcgcccc aaggccagtg gcgccactga gaggttggcg ccactccacc agctgctgca   1380

gcccatggcc ggctgtgccc gcgtggccca gtgtgcccag gccgtgccca cgctgctgca   1440

ggcattcttc tcagcagtga cccaggtggc tgacgggtcc ctgatcaacc agctggcgct   1500

gctgctcctg ggcaggagcg actcgctcta cccggcccca gggtacgctg ccggtgtgca   1560

caggtaggtc cctcctgcgc tcctgccaca gccctgggcg ggtgcctcct ggactcctcc   1620

ccctctcccc tcccccctcc ccttcagtgg cttcggcacc acccctagct gggccctcag   1680

cagcctcaga ccctgccacc cccacccaca gccccacacc cagccccagg cacttctctc   1740

tgcttctcaa gaacattccc gtccttcttt ctgccgagcc tgtcctcttc agggttagct   1800

caggtccctc ttccccgtct tgtcccctgg ggtccttctc tccaaaggcc tgatgcatgc   1860

aggcccatcc tggttccact ctgagcctgg gcctgaggcc agcgctggtg ccagccttct   1920

ccccagtgag aacagtttct ctgaggctgg cagtcttctg tgttcctcta tcggagggtg   1980

cagcatacac ctaccactca gacgcttccc gggtttctcc aggcccttgg cctggatggg   2040

gatggggtca taggtctgca cagagcaggc gtagacccgg ctttctgggc agtgtgctga   2100

gttctcagtt cctggccctg tgtacgctga aaccctccct ggtggtggag ctggcaagag   2160

acctgctgga gttcctgggc agcgtgaatg gtctctgcag cagggcgagc ctcgtcacca   2220

gcgtggtgtg ggccatcggc gagtacctgt cggtgaccta cgatcggagg tgcaccgtgg   2280

agcagatcaa caagttcttc gaagccctgg aggctctgct attcgaggtc acccagtgcc   2340

gcccctctgc tgccctgccc aggtgtcccc cccaggtggt caccgtgctg atgaccacgc   2400

tgacgaagct ggcctcccgg agccaagatc tgatccccag ggcctcttta ttgctgtcaa   2460

agatgaggac cctggctcac agtccagcca ccagctccac gcacagcgag gagggcgcgg   2520

aagccatccg tacccgggcc acagagctgc tgaccctgct gaagatgcct agcgtggccc   2580

agtttgtgct cacacccagc acggaggtgt gcagcccccg ctatcaccgc gatgccaaca   2640

cggccctgcc cctggccctg cgcacggtca gccggctggt ggagagggag gccggcctca   2700

tgccagggtg aagggacagt ggccagggac ttcggtgcag attaagagcc tgggcagcca   2760

gcttgctact gaggccaggc tgataggagc tcaggagggc gcgggagtcc tgggagagga   2820

ggcaaggccc acggtgggct tggcaccctc acagacacgc ggggctggcc cccctgctca   2880

ccctctgggc tttgtctccg agccttttgc tcccaggcaa cactgagctg agctgagggg   2940

tgccatggag cggctctgat tggaggcttg aggccctgtg gctgggtcgg gtggaggctg   3000

ctgggtctgt ttcctagtct tttgtttttg gacagttgat gggcaagaag agctgcagta   3060

aaagtaaatc tcctttaata agcgtctgta tgaagagtgc gcgatcagtt ccgttacctg   3120

ccctgcaccc tggggagagg accagggatg ggaacccctg gcagctgctg ccagtcctgg   3180

aggctcagcc cggcgtgcca ctgctgctac agaaaccagg tcatttgtgc acagcccgga   3240

aggcagcggc gcgagttccc gggtgtggtc accgctctgg gtggtgcgct tgtcaatgcc   3300

ccttttgatg cccttgaata gcctgaagat gaaggggacc gggggagggt tgcaagcgcc   3360

atggcctatg caggctgcgg cctctggcca ttcggaggga aggccccagg gagccacctg   3420

agtggagctc agaacactgg attcgcgcga aggggaggtg tctgggcgtg cggccccagc   3480

cccgccacct tcctgggccc tgtggtccca ccctccggac taccaaggca cagctgtgtc   3540

gcacgttccg cccggtgcct gggacgggct cagccgccag ggggcgccgc cgccccgaga   3600

gcctcacgcc ccgcccccag gctcaaactc ttccccctcc ccactctggc tccgcccccg   3660

gtctcctctt ttgctctggc cccgcccacc tcccctccgg cctcggcccc gcccccaatc   3720

ccccatagct ctgcgactaa gaaaccacag gctgaaggcg actgcagggt cctgcccctt   3780

gcccagcctc aggactatgg agggggcgag tgacgcgcaa ggaacggagc aggggacacc   3840

gtgcgggctc aggagctccc cagatgcccg a                                  3871


<210>  3563
<211>  446
<212>  PRT
<213>  Homo sapiens

<400>  3563

Met Ala Lys Val Val Val Leu Ser Pro Gly Thr Leu Gln Glu Asp Gln 
1               5                   10                  15


Ala Thr Leu Leu Ser Lys Arg Leu Val Asp Trp Leu Arg Tyr Ala Ser 
            20                  25                  30


Leu Gln Gln Gly Leu Pro His Ser Gly Gly Phe Phe Ser Thr Pro Arg 
        35                  40                  45


Ala Arg Gln Pro Gly Pro Val Thr Glu Val Asp Gly Ala Val Ala Thr 
    50                  55                  60


Asp Phe Phe Thr Val Leu Ser Ser Gly His Arg Phe Thr Asp Asp Gln 
65                  70                  75                  80


Trp Leu Asn Val Gln Ala Phe Ser Met Leu Arg Ala Trp Leu Leu His 
                85                  90                  95


Ser Gly Pro Glu Gly Pro Gly Thr Leu Asp Thr Asp Asp Arg Ser Glu 
            100                 105                 110


Gln Glu Gly Ser Thr Leu Ser Val Ile Ser Ala Thr Ser Ser Ala Gly 
        115                 120                 125


Arg Leu Leu Pro Pro Arg Glu Arg Leu Arg Glu Val Ala Phe Glu Tyr 
    130                 135                 140


Cys Gln Arg Leu Ile Glu Gln Ser Asn Arg Arg Ala Leu Arg Lys Gly 
145                 150                 155                 160


Asp Ser Asp Leu Gln Lys Ala Cys Leu Val Glu Ala Val Leu Val Leu 
                165                 170                 175


Asp Val Leu Cys Arg Gln Asp Pro Ser Phe Leu Tyr Arg Ser Leu Ser 
            180                 185                 190


Cys Leu Lys Ala Leu His Gly Arg Val Arg Gly Asp Pro Ala Ser Val 
        195                 200                 205


Arg Val Leu Leu Pro Leu Ala His Phe Phe Leu Ser His Gly Glu Ala 
    210                 215                 220


Ala Ala Val Asp Ser Glu Ala Val Tyr Gln His Leu Phe Thr Arg Ile 
225                 230                 235                 240


Pro Val Glu Gln Phe His Ser Pro Met Leu Ala Phe Glu Phe Ile Gln 
                245                 250                 255


Phe Cys Arg Asp Asn Leu His Leu Phe Ser Gly His Leu Ser Thr Leu 
            260                 265                 270


Arg Leu Ser Phe Pro Asn Leu Phe Lys Phe Leu Ala Trp Asn Ser Pro 
        275                 280                 285


Pro Leu Thr Ser Glu Phe Val Ala Leu Leu Pro Ala Leu Val Asp Ala 
    290                 295                 300


Gly Thr Ala Leu Glu Met Leu His Ala Leu Leu Asp Leu Pro Cys Leu 
305                 310                 315                 320


Thr Ala Val Leu Asp Leu Gln Leu Arg Ser Ala Pro Ala Ala Ser Glu 
                325                 330                 335


Arg Pro Leu Trp Asp Thr Ser Leu Arg Ala Pro Ser Cys Leu Glu Ala 
            340                 345                 350


Phe Arg Asp Pro Gln Phe Gln Gly Leu Phe Gln Tyr Leu Leu Arg Pro 
        355                 360                 365


Lys Ala Ser Gly Ala Thr Glu Arg Leu Ala Pro Leu His Gln Leu Leu 
    370                 375                 380


Gln Pro Met Ala Gly Cys Ala Arg Val Ala Gln Cys Ala Gln Ala Val 
385                 390                 395                 400


Pro Thr Leu Leu Gln Ala Phe Phe Ser Ala Val Thr Gln Val Ala Asp 
                405                 410                 415


Gly Ser Leu Ile Asn Gln Leu Ala Leu Leu Leu Leu Gly Arg Ser Asp 
            420                 425                 430


Ser Leu Tyr Pro Ala Pro Gly Tyr Ala Ala Gly Val His Arg 
        435                 440                 445


<210>  3564
<211>  671
<212>  DNA
<213>  Homo sapiens

<400>  3564
gaccggggtg cggagctcct gggctgcagc tcctggagtt tccgaggttc gtgcgcgtct     60

ggtggcggcg gcgtgatgtt ctcggcagga gcggagagtt tgctccacca ggccagggag    120

atccaggacg aggagctgaa gaagttctgt tcccggatct gtaaactgct gcaggcggag    180

gacttggggc cggacaccct cgactccctg cagaggctct tcctcatcat ctcagccacg    240

aagtacagcc ggagcggctg cagtggactc ggaagccgtc taccagcacc tgttcaccag    300

gatcccggtg gagcagttcc acagccccat gctggccttt gaattcatcc agttctgcag    360

ggacaacctc cacctgttca gcgggcacct cagcaccctc agattgagct tccccaacct    420

ctttaagttc ctggcctgga acagcccacc cctcacctcc gagtttgtgg cgctcctccc    480

ggccctggtg gacgctggca cagccctgga gatgctgcac gcgctgctgg acctgccctg    540

cttgacggcg gtgctggacc tgcagctcag gtgggcccct caccctctgc cagcgctgcg    600

tctcccagcc agctggttcc acacactggg ccccctcctc gctgctcctg acccctacac    660

cggggaccct c                                                         671


<210>  3565
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  3565

Met Leu Ala Phe Glu Phe Ile Gln Phe Cys Arg Asp Asn Leu His Leu 
1               5                   10                  15


Phe Ser Gly His Leu Ser Thr Leu Arg Leu Ser Phe Pro Asn Leu Phe 
            20                  25                  30


Lys Phe Leu Ala Trp Asn Ser Pro Pro Leu Thr Ser Glu Phe Val Ala 
        35                  40                  45


Leu Leu Pro Ala Leu Val Asp Ala Gly Thr Ala Leu Glu Met Leu His 
    50                  55                  60


Ala Leu Leu Asp Leu Pro Cys Leu Thr Ala Val Leu Asp Leu Gln Leu 
65                  70                  75                  80


Arg Trp Ala Pro His Pro Leu Pro Ala Leu Arg Leu Pro Ala Ser Trp 
                85                  90                  95


Phe His Thr Leu Gly Pro Leu Leu Ala Ala Pro Asp Pro Tyr Thr Gly 
            100                 105                 110


Asp 



<210>  3566
<211>  1038
<212>  DNA
<213>  Homo sapiens

<400>  3566
agggacctgg ggtctcacta tgttgcccag gctggtctca aacttctggg ctcaagcaat     60

ccaccctcct tggccaggag tttttgccaa gtccatgtcc tccctccctc tgtgtcggga    120

gcaggcctgg gcactcagcg tggggatcca ggggttcaca ggctgccttt gtgtgagaga    180

agctgctatc tctgctcatg ggttgcccag gggtgcagag tctgcaggaa ggttgcgatg    240

gagctgggct tttccctccg ttcccagcct gcagcgtcat gagttgcctc ctgtgctggg    300

gtgcagcctg cggttgcttt agttctgtgt gggcgagagc ttgtgggccc cggcgtactc    360

agggcgttgt acttcatcac tggggtcatc ctggttggtg cccagccccc tcacctcaca    420

gacctcctgc aggccacctc caggcctccg agatgacccc ggtaatgctg tggtagctcg    480

tggccttcga gtactgccag cgcctcattg agcaaagtaa ccgacgagcc ctgaggaagg    540

gggactccga cctgcagaaa gcttgcctgg tggaggccgt gctggtgctg gacgtgctgt    600

gccggcagga cccgtccttc ctgtaccgaa gtctctcctg cctgaaggcc ctgcacgggc    660

gggtgcgcgg ggacccggcc tctgtgcggg tgctgctgcc cctcgcccac ttcttcctga    720

gccacgccca ggaaacctga aagtctagga accagcacct tccaaagaat gtgccatagt    780

gtgtgtgact cacgagctgt ccgtgtccct gggcgaggga gaccaagtgc cgcttcccca    840

gcgtcccagc gtaggacgcc tcggagccct tggtgtcctg gagagcaggc ctgagactca    900

gggcccctaa ccagtcacag aagcacggcc agggcgaggt caagacgtgt gccctggcgg    960

gccctggtct tgcaggggaa gcggctgcag tggactcgga agccgtctac cagcacctgt   1020

tcaccaggat cccggtgg                                                 1038


<210>  3567
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  3567

Met Leu Pro Arg Leu Val Ser Asn Phe Trp Ala Gln Ala Ile His Pro 
1               5                   10                  15


Pro Trp Pro Gly Val Phe Ala Lys Ser Met Ser Ser Leu Pro Leu Cys 
            20                  25                  30


Arg Glu Gln Ala Trp Ala Leu Ser Val Gly Ile Gln Gly Phe Thr Gly 
        35                  40                  45


Cys Leu Cys Val Arg Glu Ala Ala Ile Ser Ala His Gly Leu Pro Arg 
    50                  55                  60


Gly Ala Glu Ser Ala Gly Arg Leu Arg Trp Ser Trp Ala Phe Pro Ser 
65                  70                  75                  80


Val Pro Ser Leu Gln Arg His Glu Leu Pro Pro Val Leu Gly Cys Ser 
                85                  90                  95


Leu Arg Leu Leu 
            100


<210>  3568
<211>  440
<212>  DNA
<213>  Homo sapiens

<400>  3568
aggtggacgg ggcggtagcc acagacttct tcacggtgga gagggaggcc ggcctcatgc     60

cagggtgaag ggacagtggc cagggacttc ggtgcagatt aagagcctgg gcagccagct    120

tgctactgag gccaggctga taggagctca ggagggcgcg ggagtcctgg gagaggaggc    180

aaggcccacg gtgggcttgg caccctcaca gacacgcggg gctggccccc ctgctcaccc    240

tctgggcttt gtctccgagc cttttgctcc caggcaacac tgagctgagc tgaggggtgc    300

catggagcgg ctctgattgg aggcttgagg ccctgtggct gggtcgggtg gaggctgctg    360

ggtctgtttc ctagtctttt gtttttggac agttgatggg caagaagagc tgcagtaaaa    420

gtaaatctcc tttaataagc                                                440


<210>  3569
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  3569

Gly Gly Arg Gly Gly Ser His Arg Leu Leu His Gly Gly Glu Gly Gly 
1               5                   10                  15


Arg Pro His Ala Arg Val Lys Gly Gln Trp Pro Gly Thr Ser Val Gln 
            20                  25                  30


Ile Lys Ser Leu Gly Ser Gln Leu Ala Thr Glu Ala Arg Leu Ile Gly 
        35                  40                  45


Ala Gln Glu Gly Ala Gly Val Leu Gly Glu Glu Ala Arg Pro Thr Val 
    50                  55                  60


Gly Leu Ala Pro Ser Gln Thr Arg Gly Ala Gly Pro Pro Ala His Pro 
65                  70                  75                  80


Leu Gly Phe Val Ser Glu Pro Phe Ala Pro Arg Gln His 
                85                  90


<210>  3570
<211>  1228
<212>  DNA
<213>  Homo sapiens

<400>  3570
aggtggacgg ggcggtagcc acagacttct tcacggtgga gagggaggcc ggcctcatgc     60

cagggtgaag ggacagtggc cagggacttc ggtgcagatt aagagcctgg gcagccagct    120

tgctactgag gccaggctga taggagctca ggagggcgcg ggagtcctgg gagaggaggc    180

aaggcccacg gtgggcttgg caccctcaca gacacgcggg gctggccccc ctgctcaccc    240

tctgggcttt gtctccgagc cttttgctcc caggcaacac tgagctgagc tgaggggtgc    300

catggagcgg ctctgattgg aggcttgagg ccctgtggct gggtcgggtg gaggctgctg    360

ggtctgtttc ctagtctttt gtttttggac agttgatggg caagaagagc tgcagtaaaa    420

gtaaatctcc tttaataagc gtctgtatga agagtgcgcg atcagttccg ttacctgccc    480

tgcaccctgg ggagaggacc agggatggga acccctggca gctgctgcca gtcctggagg    540

ctcagcccgg cgtgccactg ctgctacaga aaccaggtca tttgtgcaca gcccggaagg    600

cagcggcgcg agttcccggg tgtggtcacc gctctgggtg gtgcgcttgt caatgcccct    660

tttgatgccc ttgaatagcc tgaagatgaa ggggaccggg ggagggttgc aagcgccatg    720

gcctatgcag gctgcggcct ctggccattc ggagggaagg ccccagggag ccacctgagt    780

ggagctcaga acactggatt cgcgcgaagg ggaggtgtct gggcgtgcgg ccccagcccc    840

gccaccttcc tgggccctgt ggtcccaccc tccggactac caaggcacag ctgtgtcgca    900

cgttccgccc ggtgcctggg acgggctcag ccgccagggg gcgccgccgc cccgagagcc    960

tcacgccccg cccccaggct caaactcttc cccctcccca ctctggctcc gcccccggtc   1020

tcctcttttg ctctggcccc gcccacctcc cctccggcct cggccccgcc cccaatcccc   1080

catagctctg cgactaagaa accacaggct gaaggcgact gcagggtcct gccccttgcc   1140

cagcctcagg actatggagg gggcgagtga cgcgcaagga acggagcagg ggacaccgtg   1200

cgggctcagg agctccccag atgcccga                                      1228


<210>  3571
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  3571

Met Ala Tyr Ala Gly Cys Gly Leu Trp Pro Phe Gly Gly Lys Ala Pro 
1               5                   10                  15


Gly Ser His Leu Ser Gly Ala Gln Asn Thr Gly Phe Ala Arg Arg Gly 
            20                  25                  30


Gly Val Trp Ala Cys Gly Pro Ser Pro Ala Thr Phe Leu Gly Pro Val 
        35                  40                  45


Val Pro Pro Ser Gly Leu Pro Arg His Ser Cys Val Ala Arg Ser Ala 
    50                  55                  60


Arg Cys Leu Gly Arg Ala Gln Pro Pro Gly Gly Ala Ala Ala Pro Arg 
65                  70                  75                  80


Ala Ser Arg Pro Ala Pro Arg Leu Lys Leu Phe Pro Leu Pro Thr Leu 
                85                  90                  95


Ala Pro Pro Pro Val Ser Ser Phe Ala Leu Ala Pro Pro Thr Ser Pro 
            100                 105                 110


Pro Ala Ser Ala Pro Pro Pro Ile Pro His Ser Ser Ala Thr Lys Lys 
        115                 120                 125


Pro Gln Ala Glu Gly Asp Cys Arg Val Leu Pro Leu Ala Gln Pro Gln 
    130                 135                 140


Asp Tyr Gly Gly Gly Glu 
145                 150


<210>  3572
<211>  1549
<212>  DNA
<213>  Homo sapiens

<400>  3572
caacctccac ctgttcagcg ggcacctcag caccctcaga ttgagcttcc ccaacctctt     60

taagttcctg gcctggaaca gcccacccct cacctccgag tttgtggcgc tcctcccggc    120

cctggtggac gctggcacag ccctggagat gctgcacgcg ctgctggacc tgccctgctt    180

gacggcggtg ctggacctgc agctcaggtc agcaccggct gcatccgaga ggccactctg    240

ggacacctct ctcagggccc ccagctgcct ggaggccttc cgggacccgc agttccaggg    300

tcttttccaa tacctgctgc gccccaaggc cagtggcgcc actgagaggt tggcgccact    360

ccaccagctg ctgcagccca tggccggctg tgcccgcgtg gcccagtgtg cccaggccgt    420

gcccacgctg ctgcaggcat tcttctcagc agtgacccag gtggctgacg ggtccctgat    480

caaccagctg gcgctgctgc tcctgggcag gagcgactcg ctctacccgg ccccagggta    540

cgctgccggt gtgcacagtg tgctgagttc tcagttcctg gccctgtgta cgctgaaacc    600

ctccctggtg gtggagctgg caagagacct gctggagttc ctgggcagcg tgaatggtct    660

ctgcagcagg gcgagcctcg tcaccagcgt ggtgtgggcc atcggcgagt acctgtcggt    720

gacctacgat cggaggtgca ccgtggagca gatcaacaag ttcttcgaag ccctggaggc    780

tctgctattc gaggtcaccc agtgccgccc ctctgctgcc ctgcccaggt gtccccccca    840

ggtggtcacc gtgctgatga ccacgctgac gaagctggcc tcccggagcc aagatctgat    900

ccccagggcc tctttattgc tgtcaaagat gaggaccctg gctcacagtc cagccaccag    960

ctccacgcac agcgaggagg gcgcggaagc catccgtacc cgggccacag agctgctgac   1020

cctgctgaag atgcctagcg tggcccagtt tgtgctcaca cccagcacgg aggtgtgcag   1080

cccccgctat caccgcgatg ccaacacggc cctgcccctg gccctgcgca cggtcagccg   1140

gctggtggag agggaggccg gcctcatgcc agggtgaagg gacagtggcc agggacttcg   1200

gtgcagatta agagcctggg cagccagctt gctactgagg ccaggctgat aggagctcag   1260

gagggcgcgg gagtcctggg agaggaggca aggcccacgg tgggcttggc accctcacag   1320

acacgcgggg ctggcccccc tgctcaccct ctgggctttg tctccgagcc ttttgctccc   1380

aggcaacact gagctgagct gaggggtgcc atggagcggc tctgattgga ggcttgaggc   1440

cctgtggctg ggtcgggtgg aggctgctgg gtctgtttcc tagtcttttg tttttggaca   1500

gttgatgggc aagaagagct gcagtaaaag taaatctcct ttaataagc               1549


<210>  3573
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  3573

Met Leu His Ala Leu Leu Asp Leu Pro Cys Leu Thr Ala Val Leu Asp 
1               5                   10                  15


Leu Gln Leu Arg Ser Ala Pro Ala Ala Ser Glu Arg Pro Leu Trp Asp 
            20                  25                  30


Thr Ser Leu Arg Ala Pro Ser Cys Leu Glu Ala Phe Arg Asp Pro Gln 
        35                  40                  45


Phe Gln Gly Leu Phe Gln Tyr Leu Leu Arg Pro Lys Ala Ser Gly Ala 
    50                  55                  60


Thr Glu Arg Leu Ala Pro Leu His Gln Leu Leu Gln Pro Met Ala Gly 
65                  70                  75                  80


Cys Ala Arg Val Ala Gln Cys Ala Gln Ala Val Pro Thr Leu Leu Gln 
                85                  90                  95


Ala Phe Phe Ser Ala Val Thr Gln Val Ala Asp Gly Ser Leu Ile Asn 
            100                 105                 110


Gln Leu Ala Leu Leu Leu Leu Gly Arg Ser Asp Ser Leu Tyr Pro Ala 
        115                 120                 125


Pro Gly Tyr Ala Ala Gly Val His Ser Val Leu Ser Ser Gln Phe Leu 
    130                 135                 140


Ala Leu Cys Thr Leu Lys Pro Ser Leu Val Val Glu Leu Ala Arg Asp 
145                 150                 155                 160


Leu Leu Glu Phe Leu Gly Ser Val Asn Gly Leu Cys Ser Arg Ala Ser 
                165                 170                 175


Leu Val Thr Ser Val Val Trp Ala Ile Gly Glu Tyr Leu Ser Val Thr 
            180                 185                 190


Tyr Asp Arg Arg Cys Thr Val Glu Gln Ile Asn Lys Phe Phe Glu Ala 
        195                 200                 205


Leu Glu Ala Leu Leu Phe Glu Val Thr Gln Cys Arg Pro Ser Ala Ala 
    210                 215                 220


Leu Pro Arg Cys Pro Pro Gln Val Val Thr Val Leu Met Thr Thr Leu 
225                 230                 235                 240


Thr Lys Leu Ala Ser Arg Ser Gln Asp Leu Ile Pro Arg Ala Ser Leu 
                245                 250                 255


Leu Leu Ser Lys Met Arg Thr Leu Ala His Ser Pro Ala Thr Ser Ser 
            260                 265                 270


Thr His Ser Glu Glu Gly Ala Glu Ala Ile Arg Thr Arg Ala Thr Glu 
        275                 280                 285


Leu Leu Thr Leu Leu Lys Met Pro Ser Val Ala Gln Phe Val Leu Thr 
    290                 295                 300


Pro Ser Thr Glu Val Cys Ser Pro Arg Tyr His Arg Asp Ala Asn Thr 
305                 310                 315                 320


Ala Leu Pro Leu Ala Leu Arg Thr Val Ser Arg Leu Val Glu Arg Glu 
                325                 330                 335


Ala Gly Leu Met Pro Gly 
            340


<210>  3574
<211>  576
<212>  DNA
<213>  Homo sapiens

<400>  3574
ctgttcagcg ggcacctcag caccctcaga ttgagcttcc ccaacctctt taagctccga     60

gccgtgtccg aaccgctgtg ctgtgcccac agttcctggc ctggaacagc ccacccctca    120

cctccgagtt tgtggcgctc ctcccggccc tggtggacgc tggcacagcc ctggagatgc    180

tgcacgcgct gctggacctg ccctgcttga cggcggtgct ggacctgcag ctcaggtcag    240

caccggctgc atccgagagg ccactctggg acacctctct cagggccccc agctgcctgg    300

aggccttccg ggacccgcag ttccagggtc ttttccaata cctgctgcgc cccaaggcca    360

gtggcgccac tgagaggttg gcgccactcc accagctgct gcagcccatg gccggctgtg    420

cccgcgtggc ccagtgtgcc caggccgtgc ccacgctgct gcaggcattc ttctcagcag    480

tgacccaggt gagctcgctg cctggggccc cccattccca caggcctcac aactgagggg    540

caggccagag ccagcactgg ggggccctct tgagct                              576


<210>  3575
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  3575

Met Leu His Ala Leu Leu Asp Leu Pro Cys Leu Thr Ala Val Leu Asp 
1               5                   10                  15


Leu Gln Leu Arg Ser Ala Pro Ala Ala Ser Glu Arg Pro Leu Trp Asp 
            20                  25                  30


Thr Ser Leu Arg Ala Pro Ser Cys Leu Glu Ala Phe Arg Asp Pro Gln 
        35                  40                  45


Phe Gln Gly Leu Phe Gln Tyr Leu Leu Arg Pro Lys Ala Ser Gly Ala 
    50                  55                  60


Thr Glu Arg Leu Ala Pro Leu His Gln Leu Leu Gln Pro Met Ala Gly 
65                  70                  75                  80


Cys Ala Arg Val Ala Gln Cys Ala Gln Ala Val Pro Thr Leu Leu Gln 
                85                  90                  95


Ala Phe Phe Ser Ala Val Thr Gln Val Ser Ser Leu Pro Gly Ala Pro 
            100                 105                 110


His Ser His Arg Pro His Asn 
        115


<210>  3576
<211>  2344
<212>  DNA
<213>  Homo sapiens

<400>  3576
ccgggacccg cagttccagg gtcttttcca atacctgctg cgccccaagg ccagtggcgc     60

cactgagagg tacggggccc tagggccagg gggccaccag tggctcagag agcccggcca    120

cagccactgg ggtggggctc actgctcagc cctaggctga ggccagggtg ctttgtgtcc    180

cacacaaggc tgcgtccccg tcatcaccat tatagaggcc ctgcttctgc accacgggtc    240

tgccgggggc ggggcctggt ctcagctctc tctgctgccc acatcaaccc tcataagctt    300

ggaggttggc cctgtgggtg ctccattttg cagatggaca aaccgagcct gagcccagga    360

agcaggaggc ctgggaccgg ccacaggcct cctgccctca gcccacgcca gcctttgtcc    420

cgatggcttt actgtcccgg gtgtgctgac gccaggggtc tccccaaacc caggggagca    480

ggaggtcccg agaggcgatg agtgaggatg ggagcgggct cagctgtgcg agagggagca    540

gtggcgacgt ggccccggcc tgcagtcacc aggtcgggga gcgggcagca ctcacggcca    600

cactgtgtcc tcaggttggc gccactccac cagctgctgc agcccatggc cggctgtgcc    660

cgcgtggccc agtgtgccca ggccgtgccc acgctgctgc aggcattctt ctcagcagtg    720

acccaggtgg ctgacgggtc cctgatcaac cagctggcgc tgctgctcct gggcaggagc    780

gactcgctct acccggcccc agggtacgct gccggtgtgc acaggtaggt ccctcctgcg    840

ctcctgccac agccctgggc gggtgcctcc tggactcctc cccctctccc ctcccccctc    900

cccttcagtg gcttcggcac cacccctagc tgggccctca gcagcctcag accctgccac    960

ccccacccac agccccacac ccagccccag gcacttctct ctgcttctca agaacattcc   1020

cgtccttctt tctgccgagc ctgtcctctt cagggttagc tcaggtccct cttccccgtc   1080

ttgtcccctg gggtccttct ctccaaaggc ctgatgcatg caggcccatc ctggttccac   1140

tctgagcctg ggcctgaggc cagcgctggt gccagccttc tccccagtga gaacagtttc   1200

tctgaggctg gcagtcttct gtgttcctct atcggagggt gcagcataca cctaccactc   1260

agacgcttcc cgggtttctc caggcccttg gcctggatgg ggatggggtc ataggtctgc   1320

acagagcagg cgtagacccg gctttctggg cagtgtgctg agttctcagt tcctggccct   1380

gtgtacgctg aaaccctccc tggtggtgga gctggcaaga gacctgctgg agttcctggg   1440

cagcgtgaat ggtctctgca gcagggcgag cctcgtcacc agcgtggtgt gggccatcgg   1500

cgagtacctg tcggtgacct acgatcggag gtgcaccgtg gagcagatca acaagttctt   1560

cgaagccctg gaggctctgc tattcgaggt cacccagtgc cgcccctctg ctgccctgcc   1620

caggtgtccc ccccaggtgg tcaccgtgct gatgaccacg ctgacgaagc tggcctcccg   1680

gagccaagat ctgatcccca gggcctcttt attgctgtca aagatgagga ccctggctca   1740

cagtccagcc accagctcca cgcacagcga ggagggcgcg gaagccatcc gtacccgggc   1800

cacagagctg ctgaccctgc tgaagatgcc tagcgtggcc cagtttgtgc tcacacccag   1860

cacggaggtg tgcagccccc gctatcaccg cgatgccaac acggccctgc ccctggccct   1920

gcgcacggtc agccggctgg tggagaggga ggccggcctc atgccagggt gaagggacag   1980

tggccaggga cttcggtgca gattaagagc ctgggcagcc agcttgctac tgaggccagg   2040

ctgataggag ctcaggaggg cgcgggagtc ctgggagagg aggcaaggcc cacggtgggc   2100

ttggcaccct cacagacacg cggggctggc ccccctgctc accctctggg ctttgtctcc   2160

gagccttttg ctcccaggca acactgagct gagctgaggg gtgccatgga gcggctctga   2220

ttggaggctt gaggccctgt ggctgggtcg ggtggaggct gctgggtctg tttcctagtc   2280

ttttgttttt ggacagttga tgggcaagaa gagctgcagt aaaagtaaat ctcctttaat   2340

aagc                                                                2344


<210>  3577
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  3577

Met Gln Ala His Pro Gly Ser Thr Leu Ser Leu Gly Leu Arg Pro Ala 
1               5                   10                  15


Leu Val Pro Ala Phe Ser Pro Val Arg Thr Val Ser Leu Arg Leu Ala 
            20                  25                  30


Val Phe Cys Val Pro Leu Ser Glu Gly Ala Ala Tyr Thr Tyr His Ser 
        35                  40                  45


Asp Ala Ser Arg Val Ser Pro Gly Pro Trp Pro Gly Trp Gly Trp Gly 
    50                  55                  60


His Arg Ser Ala Gln Ser Arg Arg Arg Pro Gly Phe Leu Gly Ser Val 
65                  70                  75                  80


Leu Ser Ser Gln Phe Leu Ala Leu Cys Thr Leu Lys Pro Ser Leu Val 
                85                  90                  95


Val Glu Leu Ala Arg Asp Leu Leu Glu Phe Leu Gly Ser Val Asn Gly 
            100                 105                 110


Leu Cys Ser Arg Ala Ser Leu Val Thr Ser Val Val Trp Ala Ile Gly 
        115                 120                 125


Glu Tyr Leu Ser Val Thr Tyr Asp Arg Arg Cys Thr Val Glu Gln Ile 
    130                 135                 140


Asn Lys Phe Phe Glu Ala Leu Glu Ala Leu Leu Phe Glu Val Thr Gln 
145                 150                 155                 160


Cys Arg Pro Ser Ala Ala Leu Pro Arg Cys Pro Pro Gln Val Val Thr 
                165                 170                 175


Val Leu Met Thr Thr Leu Thr Lys Leu Ala Ser Arg Ser Gln Asp Leu 
            180                 185                 190


Ile Pro Arg Ala Ser Leu Leu Leu Ser Lys Met Arg Thr Leu Ala His 
        195                 200                 205


Ser Pro Ala Thr Ser Ser Thr His Ser Glu Glu Gly Ala Glu Ala Ile 
    210                 215                 220


Arg Thr Arg Ala Thr Glu Leu Leu Thr Leu Leu Lys Met Pro Ser Val 
225                 230                 235                 240


Ala Gln Phe Val Leu Thr Pro Ser Thr Glu Val Cys Ser Pro Arg Tyr 
                245                 250                 255


His Arg Asp Ala Asn Thr Ala Leu Pro Leu Ala Leu Arg Thr Val Ser 
            260                 265                 270


Arg Leu Val Glu Arg Glu Ala Gly Leu Met Pro Gly 
        275                 280


<210>  3578
<211>  3132
<212>  DNA
<213>  Homo sapiens

<400>  3578
ccgggacccg cagttccagg gtcttttcca atacctgctg cgccccaagg ccagtggcgc     60

cactgagagg tacggggccc tagggccagg gggccaccag tggctcagag agcccggcca    120

cagccactgg ggtggggctc actgctcagc cctaggctga ggccagggtg ctttgtgtcc    180

cacacaaggc tgcgtccccg tcatcaccat tatagaggcc ctgcttctgc accacgggtc    240

tgccgggggc ggggcctggt ctcagctctc tctgctgccc acatcaaccc tcataagctt    300

ggaggttggc cctgtgggtg ctccattttg cagatggaca aaccgagcct gagcccagga    360

agcaggaggc ctgggaccgg ccacaggcct cctgccctca gcccacgcca gcctttgtcc    420

cgatggcttt actgtcccgg gtgtgctgac gccaggggtc tccccaaacc caggggagca    480

ggaggtcccg agaggcgatg agtgaggatg ggagcgggct cagctgtgcg agagggagca    540

gtggcgacgt ggccccggcc tgcagtcacc aggtcgggga gcgggcagca ctcacggcca    600

cactgtgtcc tcaggttggc gccactccac cagctgctgc agcccatggc cggctgtgcc    660

cgcgtggccc agtgtgccca ggccgtgccc acgctgctgc aggcattctt ctcagcagtg    720

acccaggtgg ctgacgggtc cctgatcaac cagctggcgc tgctgctcct gggcaggagc    780

gactcgctct acccggcccc agggtacgct gccggtgtgc acaggtaggt ccctcctgcg    840

ctcctgccac agccctgggc gggtgcctcc tggactcctc cccctctccc ctcccccctc    900

cccttcagtg gcttcggcac cacccctagc tgggccctca gcagcctcag accctgccac    960

ccccacccac agccccacac ccagccccag gcacttctct ctgcttctca agaacattcc   1020

cgtccttctt tctgccgagc ctgtcctctt cagggttagc tcaggtccct cttccccgtc   1080

ttgtcccctg gggtccttct ctccaaaggc ctgatgcatg caggcccatc ctggttccac   1140

tctgagcctg ggcctgaggc cagcgctggt gccagccttc tccccagtga gaacagtttc   1200

tctgaggctg gcagtcttct gtgttcctct atcggagggt gcagcataca cctaccactc   1260

agacgcttcc cgggtttctc caggcccttg gcctggatgg ggatggggtc ataggtctgc   1320

acagagcagg cgtagacccg gctttctggg cagtgtgctg agttctcagt tcctggccct   1380

gtgtacgctg aaaccctccc tggtggtgga gctggcaaga gacctgctgg agttcctggg   1440

cagcgtgaat ggtctctgca gcagggcgag cctcgtcacc agcgtggtgt gggccatcgg   1500

cgagtacctg tcggtgacct acgatcggag gtgcaccgtg gagcagatca acaagttctt   1560

cgaagccctg gaggctctgc tattcgaggt cacccagtgc cgcccctctg ctgccctgcc   1620

caggtgtccc ccccaggtgg tcaccgtgct gatgaccacg ctgacgaagc tggcctcccg   1680

gagccaagat ctgatcccca gggcctcttt attgctgtca aagatgagga ccctggctca   1740

cagtccagcc accagctcca cgcacagcga ggagggcgcg gaagccatcc gtacccgggc   1800

cacagagctg ctgaccctgc tgaagatgcc tagcgtggcc cagtttgtgc tcacacccag   1860

cacggaggtg tgcagccccc gctatcaccg cgatgccaac acggccctgc ccctggccct   1920

gcgcacggtc agccggctgg tggagaggga ggccggcctc atgccagggt gaagggacag   1980

tggccaggga cttcggtgca gattaagagc ctgggcagcc agcttgctac tgaggccagg   2040

ctgataggag ctcaggaggg cgcgggagtc ctgggagagg aggcaaggcc cacggtgggc   2100

ttggcaccct cacagacacg cggggctggc ccccctgctc accctctggg ctttgtctcc   2160

gagccttttg ctcccaggca acactgagct gagctgaggg gtgccatgga gcggctctga   2220

ttggaggctt gaggccctgt ggctgggtcg ggtggaggct gctgggtctg tttcctagtc   2280

ttttgttttt ggacagttga tgggcaagaa gagctgcagt aaaagtaaat ctcctttaat   2340

aagcgtctgt atgaagagtg cgcgatcagt tccgttacct gccctgcacc ctggggagag   2400

gaccagggat gggaacccct ggcagctgct gccagtcctg gaggctcagc ccggcgtgcc   2460

actgctgcta cagaaaccag gtcatttgtg cacagcccgg aaggcagcgg cgcgagttcc   2520

cgggtgtggt caccgctctg ggtggtgcgc ttgtcaatgc cccttttgat gcccttgaat   2580

agcctgaaga tgaaggggac cgggggaggg ttgcaagcgc catggcctat gcaggctgcg   2640

gcctctggcc attcggaggg aaggccccag ggagccacct gagtggagct cagaacactg   2700

gattcgcgcg aaggggaggt gtctgggcgt gcggccccag ccccgccacc ttcctgggcc   2760

ctgtggtccc accctccgga ctaccaaggc acagctgtgt cgcacgttcc gcccggtgcc   2820

tgggacgggc tcagccgcca gggggcgccg ccgccccgag agcctcacgc cccgccccca   2880

ggctcaaact cttccccctc cccactctgg ctccgccccc ggtctcctct tttgctctgg   2940

ccccgcccac ctcccctccg gcctcggccc cgcccccaat cccccatagc tctgcgacta   3000

agaaaccaca ggctgaaggc gactgcaggg tcctgcccct tgcccagcct caggactatg   3060

gagggggcga gtgacgcgca aggaacggag caggggacac cgtgcgggct caggagctcc   3120

ccagatgccc ga                                                       3132


<210>  3579
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  3579

Met Gln Ala His Pro Gly Ser Thr Leu Ser Leu Gly Leu Arg Pro Ala 
1               5                   10                  15


Leu Val Pro Ala Phe Ser Pro Val Arg Thr Val Ser Leu Arg Leu Ala 
            20                  25                  30


Val Phe Cys Val Pro Leu Ser Glu Gly Ala Ala Tyr Thr Tyr His Ser 
        35                  40                  45


Asp Ala Ser Arg Val Ser Pro Gly Pro Trp Pro Gly Trp Gly Trp Gly 
    50                  55                  60


His Arg Ser Ala Gln Ser Arg Arg Arg Pro Gly Phe Leu Gly Ser Val 
65                  70                  75                  80


Leu Ser Ser Gln Phe Leu Ala Leu Cys Thr Leu Lys Pro Ser Leu Val 
                85                  90                  95


Val Glu Leu Ala Arg Asp Leu Leu Glu Phe Leu Gly Ser Val Asn Gly 
            100                 105                 110


Leu Cys Ser Arg Ala Ser Leu Val Thr Ser Val Val Trp Ala Ile Gly 
        115                 120                 125


Glu Tyr Leu Ser Val Thr Tyr Asp Arg Arg Cys Thr Val Glu Gln Ile 
    130                 135                 140


Asn Lys Phe Phe Glu Ala Leu Glu Ala Leu Leu Phe Glu Val Thr Gln 
145                 150                 155                 160


Cys Arg Pro Ser Ala Ala Leu Pro Arg Cys Pro Pro Gln Val Val Thr 
                165                 170                 175


Val Leu Met Thr Thr Leu Thr Lys Leu Ala Ser Arg Ser Gln Asp Leu 
            180                 185                 190


Ile Pro Arg Ala Ser Leu Leu Leu Ser Lys Met Arg Thr Leu Ala His 
        195                 200                 205


Ser Pro Ala Thr Ser Ser Thr His Ser Glu Glu Gly Ala Glu Ala Ile 
    210                 215                 220


Arg Thr Arg Ala Thr Glu Leu Leu Thr Leu Leu Lys Met Pro Ser Val 
225                 230                 235                 240


Ala Gln Phe Val Leu Thr Pro Ser Thr Glu Val Cys Ser Pro Arg Tyr 
                245                 250                 255


His Arg Asp Ala Asn Thr Ala Leu Pro Leu Ala Leu Arg Thr Val Ser 
            260                 265                 270


Arg Leu Val Glu Arg Glu Ala Gly Leu Met Pro Gly 
        275                 280


<210>  3580
<211>  1953
<212>  DNA
<213>  Homo sapiens

<400>  3580
gtcctgggtg actttggaag tccgtagtgt ctcattgcag ataattttta gcttagggcc     60

tggtggctag gtcggttctc tcctttccag tcggagacct ctgccgcaaa catgctccgc    120

cagatcatcg gtcaggccaa gaagcatccg agcttgggac agaaataacc cagagccctg    180

gaacaaactg ggtcccaatg atcaatacaa gttctactca gtgaatgtgg attacagcaa    240

gctgaagaag gaacgtccag atttctaaat gaaatgtttc actataacgc tgctttagaa    300

tgaaggtctt ccagaagcca catccgcaca attttccact taaccaggaa atatttctcc    360

tctaaatgca tgaaatcatg ttggagatct ctattgtaat ctctattgga gattacaatg    420

attaaatcaa taaataactg aaacttgata tgtgtcactt ttttatgctg aaagtatgct    480

ctgaacttta gagtatagga aattaactat tagaatttaa agaatttctt gaatttctgt    540

agtttgaaaa tacgacttta agctgcttta gtaaaacact tccattttgt gtatagactg    600

ttggtaactt cactagagca tacataacaa ctggaactgg aaattataca aaagtaaatt    660

gggaaggata ctccagcatc tgacactggc aaaatggaaa cctttgagtt tctcttactg    720

gctgttgaag tgtgtgcagt ttttaacaat ggtttttact tggcatctct ttgttgtgat    780

tttcaaggtt ataagttgct ttggtcctag gattgaagtt gaaatctgag tttatcagtg    840

ctaaccatgg tgctagtagt caagagatct tgagaatttt ggctgctgag tcttggtgca    900

gggtgcaggt tttcttttct tttttctttt tttttttttt gagatagtct ctgtcaccca    960

ggctggagtg cagtggtaca aacatggatc actgcagcct ctacctcccg ggcttaagtg   1020

atcctcctgc ctcagcccct aagtagccgg gactacaggt atgtgccacc atgcccagtt   1080

aatttttgta atttttttta gagacagggt tttgccatgt tgcccaggct ggtctcaaac   1140

tcttgagctc aagcgatcca ttctcctcag cctcccaggg tgctgggatt acaggcgtga   1200

gccattgcgc ttagccatgg tgcaggtttt caaaggccag gaagtatatt cataatttta   1260

agatggggaa tatagcaagt tttcacatag gtgtgtgtaa gtcatcacat catagaaact   1320

tgaggaattc agtgacatta attttggatt ttcatacgta agtatacaat taaatgttta   1380

cagggtagta gaagcacatt ttaaatgtca ggaactgaac taagtatttg aattacgtgg   1440

attatctcaa aaattttgaa attgttaaac gagttgaatt acttgaattc attctgttag   1500

tcaaatggtg gatatttaca cccatgtagt tttgaattta gagtgtgtag agtgttttca   1560

gttaccagac tccatgcttt tacctcctat gtgtcaggta taatttgaac ctctaagaac   1620

agggtttctc aaccttgcca ctgttgacta tttctgaaag acagtttggt ttagcagacc   1680

atcccatgcg ctttagcttg tttagtagct aacttgggct ctgccactac agacaaaaag   1740

cactctttcc ctccaattcc cacaggctat gagaagaatg gagacattac caaatgtcca   1800

ttggtgggca aaattgcttc attcctacct ctgttgagaa ttactctaga tcctttggca   1860

caaattacct caaagtttaa aattgtgtaa acaaacagtg tgtcatgtaa ttgaaaaaca   1920

ttaagcaact ccaaataaat gctacattaa gaa                                1953


<210>  3581
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  3581

Met Cys His His Ala Gln Leu Ile Phe Val Ile Phe Phe Arg Asp Arg 
1               5                   10                  15


Val Leu Pro Cys Cys Pro Gly Trp Ser Gln Thr Leu Glu Leu Lys Arg 
            20                  25                  30


Ser Ile Leu Leu Ser Leu Pro Gly Cys Trp Asp Tyr Arg Arg Glu Pro 
        35                  40                  45


Leu Arg Leu Ala Met Val Gln Val Phe Lys Gly Gln Glu Val Tyr Ser 
    50                  55                  60


<210>  3582
<211>  2130
<212>  DNA
<213>  Homo sapiens

<400>  3582
agatctaagc aggcactatt aaagacagtc gcatccgggc cctcctgccg caagctgccc     60

tcccagccaa gggtccttca ggtaggaggt cctgggtgac tttggaagtc cgtagtgtct    120

cattgcagat aatttttagc ttagggcctg gtggctaggt cggttctctc ctttccagtc    180

ggagacctct gccgcaaaca tgctccgcca gatcatcggt caggccaaga agcatccgag    240

cttgatcccc ctctttgtat ttattggaac tggagctact ggagcaacac tgtatctctt    300

gcgtctggca ttgttcaatc cagatgtttg ttgggacaga aataacccag agccctggaa    360

caaactgggt cccaatgatc aatacaagtt ctactcagtg aatgtggatt acagcaagct    420

gaagaaggaa cgtccagatt tctaaatgaa atgtttcact ataacgctgc tttagaatga    480

aggtcttcca gaagccacat ccgcacaatt ttccacttaa ccaggaaata tttctcctct    540

aaatgcatga aatcatgttg gagatctcta ttgtaatctc tattggagat tacaatgatt    600

aaatcaataa ataactgaaa cttgatatgt gtcacttttt tatgctgaaa gtatgctctg    660

aactttagag tataggaaat taactattag aatttaaaga atttcttgaa tttctgtagt    720

ttgaaaatac gactttaagc tgctttagta aaacacttcc attttgtgta tagactgttg    780

gtaacttcac tagagcatac ataacaactg gaactggaaa ttatacaaaa gtaaattggg    840

aaggatactc cagcatctga cactggcaaa atggaaacct ttgagtttct cttactggct    900

gttgaagtgt gtgcagtttt taacaatggt ttttacttgg catctctttg ttgtgatttt    960

caaggttata agttgctttg gtcctaggat tgaagttgaa atctgagttt atcagtgcta   1020

accatggtgc tagtagtcaa gagatcttga gaattttggc tgctgagtct tggtgcaggg   1080

tgcaggtttt cttttctttt ttcttttttt tttttttgag atagtctctg tcacccaggc   1140

tggagtgcag tggtacaaac atggatcact gcagcctcta cctcccgggc ttaagtgatc   1200

ctcctgcctc agcccctaag tagccgggac tacaggtatg tgccaccatg cccagttaat   1260

ttttgtaatt ttttttagag acagggtttt gccatgttgc ccaggctggt ctcaaactct   1320

tgagctcaag cgatccattc tcctcagcct cccagggtgc tgggattaca ggcgtgagcc   1380

attgcgctta gccatggtgc aggttttcaa aggccaggaa gtatattcat aattttaaga   1440

tggggaatat agcaagtttt cacataggtg tgtgtaagtc atcacatcat agaaacttga   1500

ggaattcagt gacattaatt ttggattttc atacgtaagt atacaattaa atgtttacag   1560

ggtagtagaa gcacatttta aatgtcagga actgaactaa gtatttgaat tacgtggatt   1620

atctcaaaaa ttttgaaatt gttaaacgag ttgaattact tgaattcatt ctgttagtca   1680

aatggtggat atttacaccc atgtagtttt gaatttagag tgtgtagagt gttttcagtt   1740

accagactcc atgcttttac ctcctatgtg tcaggtataa tttgaacctc taagaacagg   1800

gtttctcaac cttgccactg ttgactattt ctgaaagaca gtttggttta gcagaccatc   1860

ccatgcgctt tagcttgttt agtagctaac ttgggctctg ccactacaga caaaaagcac   1920

tctttccctc caattcccac aggctatgag aagaatggag acattaccaa atgtccattg   1980

gtgggcaaaa ttgcttcatt cctacctctg ttgagaatta ctctagatcc tttggcacaa   2040

attacctcaa agtttaaaat tgtgtaaaca aacagtgtgt catgtaattg aaaaacatta   2100

agcaactcca aataaatgct acattaagaa                                    2130


<210>  3583
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  3583

Met Leu Arg Gln Ile Ile Gly Gln Ala Lys Lys His Pro Ser Leu Ile 
1               5                   10                  15


Pro Leu Phe Val Phe Ile Gly Thr Gly Ala Thr Gly Ala Thr Leu Tyr 
            20                  25                  30


Leu Leu Arg Leu Ala Leu Phe Asn Pro Asp Val Cys Trp Asp Arg Asn 
        35                  40                  45


Asn Pro Glu Pro Trp Asn Lys Leu Gly Pro Asn Asp Gln Tyr Lys Phe 
    50                  55                  60


Tyr Ser Val Asn Val Asp Tyr Ser Lys Leu Lys Lys Glu Arg Pro Asp 
65                  70                  75                  80


Phe 



<210>  3584
<211>  447
<212>  DNA
<213>  Homo sapiens

<400>  3584
gtcctgggtg actttggaag tccgtagtgt ctcattgcag ataattttta gcttagggcc     60

tggtggctag gtcggttctc tcctttccag tcggagacct ctgccgcaaa catgctccgc    120

cagatcatcg gtcaggccaa gaagcatccg agcttgggac agaaataacc cagagccctg    180

gaacaaactg ggtcccaatg atcaatacaa gttctactca gtgaatgtgg attacagcaa    240

gctgaagaag gaacgtccag atttctaaat gaaatgtttc actataacgc tgctttagaa    300

tgaaggtctt ccagaagcca catccgcaca attttccact taaccaggaa atatttctcc    360

tctaaatgca tgaaatcatg ttggagatct ctattgtaat ctctattgga gattacaatg    420

attaaatcaa taaataactg aaacttg                                        447


<210>  3585
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  3585

Val Gly Ser Leu Leu Ser Ser Arg Arg Pro Leu Pro Gln Thr Cys Ser 
1               5                   10                  15


Ala Arg Ser Ser Val Arg Pro Arg Ser Ile Arg Ala Trp Asp Arg Asn 
            20                  25                  30


Asn Pro Glu Pro Trp Asn Lys Leu Gly Pro Asn Asp Gln Tyr Lys Phe 
        35                  40                  45


Tyr Ser Val Asn Val Asp Tyr Ser Lys Leu Lys Lys Glu Arg Pro Asp 
    50                  55                  60


Phe 
65


<210>  3586
<211>  624
<212>  DNA
<213>  Homo sapiens

<400>  3586
agatctaagc aggcactatt aaagacagtc gcatccgggc cctcctgccg caagctgccc     60

tcccagccaa gggtccttca ggtaggaggt cctgggtgac tttggaagtc cgtagtgtct    120

cattgcagat aatttttagc ttagggcctg gtggctaggt cggttctctc ctttccagtc    180

ggagacctct gccgcaaaca tgctccgcca gatcatcggt caggccaaga agcatccgag    240

cttgatcccc ctctttgtat ttattggaac tggagctact ggagcaacac tgtatctctt    300

gcgtctggca ttgttcaatc cagatgtttg ttgggacaga aataacccag agccctggaa    360

caaactgggt cccaatgatc aatacaagtt ctactcagtg aatgtggatt acagcaagct    420

gaagaaggaa cgtccagatt tctaaatgaa atgtttcact ataacgctgc tttagaatga    480

aggtcttcca gaagccacat ccgcacaatt ttccacttaa ccaggaaata tttctcctct    540

aaatgcatga aatcatgttg gagatctcta ttgtaatctc tattggagat tacaatgatt    600

aaatcaataa ataactgaaa cttg                                           624


<210>  3587
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  3587

Met Leu Arg Gln Ile Ile Gly Gln Ala Lys Lys His Pro Ser Leu Ile 
1               5                   10                  15


Pro Leu Phe Val Phe Ile Gly Thr Gly Ala Thr Gly Ala Thr Leu Tyr 
            20                  25                  30


Leu Leu Arg Leu Ala Leu Phe Asn Pro Asp Val Cys Trp Asp Arg Asn 
        35                  40                  45


Asn Pro Glu Pro Trp Asn Lys Leu Gly Pro Asn Asp Gln Tyr Lys Phe 
    50                  55                  60


Tyr Ser Val Asn Val Asp Tyr Ser Lys Leu Lys Lys Glu Arg Pro Asp 
65                  70                  75                  80


Phe 



<210>  3588
<211>  599
<212>  DNA
<213>  Homo sapiens

<400>  3588
gtcctgggtg actttggaag tccgtagtgt ctcattgcag ataattttta gcttagggcc     60

tggtggctag gtcggttctc tcctttccag tcggagacct ctgccgcaaa catgctccgc    120

cagatcatcg gtcaggccaa gaagcatccg agcgtaagtt cgtgaccgct ctcctaatgt    180

tttcccttgt ccttcttgcg tcggggtgcg ccttttggta aataagaggg gtccgtgatc    240

ttggaatcct cactttgtct ggacgtcgtt gcttttggga aaatttcgaa gtgtggaaat    300

tgcagttaag ttctttggca tctcattttt cctcagcaca tcaatgtgct gtagagctaa    360

aagtctatgc aatctttaat ctgtcttaaa tccggttccc taaatacgca gcaagcattg    420

gtagcattac gttttcagag ataatgctta aagccagtat ttgtaataga tacgtttact    480

tattcagatt ctatttttca tacatcttta tagaggcacc cttaaataat ttgcaaagaa    540

tttgtttttc aagccccagg ataaaggaag ccagaaaatt taatgggaat gacatgtaa     599


<210>  3589
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  3589

Met Leu Lys Ala Ser Ile Cys Asn Arg Tyr Val Tyr Leu Phe Arg Phe 
1               5                   10                  15


Tyr Phe Ser Tyr Ile Phe Ile Glu Ala Pro Leu Asn Asn Leu Gln Arg 
            20                  25                  30


Ile Cys Phe Ser Ser Pro Arg Ile Lys Glu Ala Arg Lys Phe Asn Gly 
        35                  40                  45


Asn Asp Met 
    50


<210>  3590
<211>  1656
<212>  DNA
<213>  Homo sapiens

<400>  3590
acttcctttt cagagctgta tccgggtcgc tgctttccct attgtctgag gcagccgccc     60

tcgcgctgtg caatttctgg tctttcgttg cttctggtcc aggctaataa agtttttctt    120

tctttaattt tttttcttct agttttaacg ggagaaatta actccccggg gccgccgggt    180

tgactgcgct gcctgggccg gaggtcttct ccggccaggg agcgctgtgg gaaggggctc    240

gagcggccag ggccaggcga ggccgggggg gcggggggtt aggggaccgc ggggctactc    300

ttgggagcgc ccctgtccgg ctggctgcgc gccggtttta aatagcatct ttcggacttg    360

tcttcgcggc cccagtcccc gacctcggcg ctgcctgggc tcctgcagcc tctccctaag    420

tcttctccaa acgaccacct cacggattcc ttatggatcg cagctccaag aggaggcagg    480

tgaagccttt ggcagcttct ctgctggaag ctcttgatta tgatagttca gatgacagtg    540

attttaaagt tggagatgcc tcagattctg aagggagtgg taatggaagt gaagatgctt    600

caaaggacag tggagaaggt tcctgtagtg attctgaaga aaatatttta gaagaagaac    660

tgaatgaaga tattaaagta aaagaagaac aacttaaaaa ttctgcagag gaagaagtac    720

tatcatcaga aaaacaatta attaaaatgg aaaagaagga agaagaagaa aatggagaaa    780

gacctagaaa gaaaaaggag aaagagaagg aaaaagaaaa ggaaaaggag aaagagaagg    840

aaagagagaa ggaaaaagaa aaagcaacag tatctgagaa tgtggctgct tctgctgctg    900

ccaccacacc agccacaagt cctcctgctg ttaacacatc cccttctgtt cccactacga    960

caaccgctac agaggaacaa gtcagcgagc caaaaaaatg gaaccttcga cgaaaccgac   1020

cacttctgga ttttgtgtcc atggaagagc tgaatgacat ggatgactat gacagtgagg   1080

atgacaatga ttggcgacct actgtagtaa agagaaaagg gagatctgcg tctcagaaag   1140

agggaagtga tggagacaat gaggatgatg aagatgaggg aagcgggagt gatgaagacg   1200

agaatgatga aggcaatgat gaagatcata gtagccctgc cagtgaaggg ggttgcaaga   1260

agaagaagag taaagttctt agcagaaaca gtgctgatga tgaggaactg accaatgata   1320

gcctgaccct atctcaaagc aagagtaatg aggtagatca acccaatttt tatatctgtc   1380

tgtctgggga aaagggaatt cttctctaaa tcactctaca cattgtatta agtggcttcc   1440

ttgaaatcct atttatagac ggctgtggga tgaatgagca ccctaactgt aacatttttt   1500

catttggcca acagactttt attaaatatc tactatttgt caccgttctc aaggagctca   1560

caatctctgt cctcaaggag aaatatttag agaaatattt ttatatccat agacttggga   1620

aatgacaaag ttttccattc tcctttttat cccttt                             1656


<210>  3591
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  3591

Met Asp Arg Ser Ser Lys Arg Arg Gln Val Lys Pro Leu Ala Ala Ser 
1               5                   10                  15


Leu Leu Glu Ala Leu Asp Tyr Asp Ser Ser Asp Asp Ser Asp Phe Lys 
            20                  25                  30


Val Gly Asp Ala Ser Asp Ser Glu Gly Ser Gly Asn Gly Ser Glu Asp 
        35                  40                  45


Ala Ser Lys Asp Ser Gly Glu Gly Ser Cys Ser Asp Ser Glu Glu Asn 
    50                  55                  60


Ile Leu Glu Glu Glu Leu Asn Glu Asp Ile Lys Val Lys Glu Glu Gln 
65                  70                  75                  80


Leu Lys Asn Ser Ala Glu Glu Glu Val Leu Ser Ser Glu Lys Gln Leu 
                85                  90                  95


Ile Lys Met Glu Lys Lys Glu Glu Glu Glu Asn Gly Glu Arg Pro Arg 
            100                 105                 110


Lys Lys Lys Glu Lys Glu Lys Glu Lys Glu Lys Glu Lys Glu Lys Glu 
        115                 120                 125


Lys Glu Arg Glu Lys Glu Lys Glu Lys Ala Thr Val Ser Glu Asn Val 
    130                 135                 140


Ala Ala Ser Ala Ala Ala Thr Thr Pro Ala Thr Ser Pro Pro Ala Val 
145                 150                 155                 160


Asn Thr Ser Pro Ser Val Pro Thr Thr Thr Thr Ala Thr Glu Glu Gln 
                165                 170                 175


Val Ser Glu Pro Lys Lys Trp Asn Leu Arg Arg Asn Arg Pro Leu Leu 
            180                 185                 190


Asp Phe Val Ser Met Glu Glu Leu Asn Asp Met Asp Asp Tyr Asp Ser 
        195                 200                 205


Glu Asp Asp Asn Asp Trp Arg Pro Thr Val Val Lys Arg Lys Gly Arg 
    210                 215                 220


Ser Ala Ser Gln Lys Glu Gly Ser Asp Gly Asp Asn Glu Asp Asp Glu 
225                 230                 235                 240


Asp Glu Gly Ser Gly Ser Asp Glu Asp Glu Asn Asp Glu Gly Asn Asp 
                245                 250                 255


Glu Asp His Ser Ser Pro Ala Ser Glu Gly Gly Cys Lys Lys Lys Lys 
            260                 265                 270


Ser Lys Val Leu Ser Arg Asn Ser Ala Asp Asp Glu Glu Leu Thr Asn 
        275                 280                 285


Asp Ser Leu Thr Leu Ser Gln Ser Lys Ser Asn Glu Val Asp Gln Pro 
    290                 295                 300


Asn Phe Tyr Ile Cys Leu Ser Gly Glu Lys Gly Ile Leu Leu 
305                 310                 315


<210>  3592
<211>  5839
<212>  DNA
<213>  Homo sapiens

<400>  3592
acttcctttt cagagctgta tccgggtcgc tgctttccct attgtctgag gcagccgccc     60

tcgcgctgtg caatttctgg tctttcgttg cttctggtcc aggctaataa agtttttctt    120

tctttaattt tttttcttct agttttaacg ggagaaatta actccccggg gccgccgggt    180

tgactgcgct gcctgggccg gaggtcttct ccggccaggg agcgctgtgg gaaggggctc    240

gagcggccag ggccaggcga ggccgggggg gcggggggtt aggggaccgc ggggctactc    300

ttgggagcgc ccctgtccgg ctggctgcgc gccggtttta aatagcatct ttcggacttg    360

tcttcgcggc cccagtcccc gacctcggcg ctgcctgggc tcctgcagcc tctccctaag    420

tcttctccaa acgaccacct cacggattcc ttatggatcg cagctccaag aggaggcagg    480

tgaagccttt ggcagcttct ctgctggaag ctcttgatta tgatagttca gatgacagtg    540

attttaaagt tggagatgcc tcagattctg aagggagtgg taatggaagt gaagatgctt    600

caaaggacag tggagaaggt tcctgtagtg attctgaaga aaatatttta gaagaagaac    660

tgaatgaaga tattaaagta aaagaagaac aacttaaaaa ttctgcagag gaagaagtac    720

tatcatcaga aaaacaatta attaaaatgg aaaagaagga agaagaagaa aatggagaaa    780

gacctagaag caacagtatc tgagaatgtg gctgcttctg ctgctgccac cacaccagcc    840

acaagtcctc ctgctgttaa cacatcccct tctgttccca ctacgacaac cgctacagag    900

gaacaagtca gcgagccaaa aaaatggaac cttcgacgaa accgaccact tctggatttt    960

gtgtccatgg aagagctgaa tgacatggat gactatgaca gtgaggatga caatgattgg   1020

cgacctactg tagtaaagag aaaagggaga tctgcgtctc agaaagaggg aagagtagcc   1080

ctgccagtga agggggttgc aagaagaaga agagtaaagt tcttagcaga aacagtgctg   1140

atgatgagga actgaccaat gatagcctga ccctatctca aagcaagagt aatgaggact   1200

cgctgattct tgagaagagt caaaactgga gctctcaaaa aatggaccat attctgattt   1260

gctgtgtttg tctgggagat aatagtgagg acgctgatga aataattcag tgtgacaatt   1320

gtggcattac agtccatgaa ggttgttatg gagttgatgg agagagtgac tctattatga   1380

gttcagcttc tgaaaactcc actgaacctt ggttttgtga tgcctgtaaa tgtggtgttt   1440

ctcctagctg tgaactgtgt cctaatcagg atggaatttt caaggagaca gatgctggaa   1500

gatgggttca tattgtttgt gccctgtatg ttcctggagt agcctttgga gatattgaca   1560

aattacgacc agtaacacta acggaaatga actattccaa atatggtgcc aaggagtgta   1620

gcttttgtga agaccctcgc tttgctagaa ctggggtttg cattagctgt gatgcaggga   1680

tgtgcagagc ctatttccat gtgacctgtg ctcaaaagga aggtctgctt tcagaggcag   1740

cggcggaaga ggatatagca gatccattct ttgcttattg taagcaacat gcagataggt   1800

tagacagaaa gtggaagaga aaaaactact tggctctaca gtcctattgt aaaatgtctt   1860

tgcaagagag agagaagcaa ctatcaccag aagcacaggc aaggatcaat gcccggcttc   1920

agcagtatcg tgccaaagca gaactagctc gatctaccag accccaggcc tgggttccaa   1980

gggaaaaatt gcccagacca ctcaccagca gtgcttcagc tattcgtaaa cttatgcgga   2040

aagcagaact catggggatc agtacagata tctttccagt ggacaattca gatactagtt   2100

ctagtgtgga tggaaggaga aaacataagc aaccagctct cactgcagat tttgtgaatt   2160

attattttga gagaaatatg cgcatgattc aaattcagga aaatatggct gaacaaaaga   2220

atataaaaga taaattagag aatgaacaag aaaagcttca tgtagaatat aataagctat   2280

gtgaatcttt agaagaacta caaaacctga atggaaaact tcgaagtgaa ggacaaggaa   2340

tatgggcttt actaggcaga atcacagggc agaagttgaa tataccggca attttgcgag   2400

cacccaagga gagaaaacca agtaaaaaag aaggaggcac acaaaagaca tctactcttc   2460

ctgcagtact ttatagttgt gggatttgta agaagaacca tgatcagcat cttcttttat   2520

tgtgtgatac ctgtaaacta cattaccatc ttggatgtct ggatcctcct cttacaagga   2580

tgccaagaaa gaccaaaaac agttattggc agtgctcgga atgtgaccag gcagggagca   2640

gtgacatgga agcagatatg gccatggaaa ccctaccaga tggaaccaaa cgatcaagga   2700

ggcagattaa ggaaccagtg aaatttgttc cacaggatgt gccaccagaa cccaagaaga   2760

ttccgataag aaacacgaga accagaggac gaaaacgaag cttcgttcct gaggaagaaa   2820

aacatgagga aagagttcct agagagagaa gacaaagaca gtctgtgttg caaaagaagc   2880

ccaaggctga agatttaaga actgaatgtg caacttgcaa gggaactgga gacaatgaaa   2940

atcttgtcag atacccttca tgagacccaa ctctgccaca gctcatcctc ggaggcaatc   3000

ccggaaacct cttttataag tgtgatttta aaaatgtgga ttaaactctc gatagagtac   3060

ataaagtaaa ggagaacagc tatattgtcc tttctataag cttgtcactg caaaaagttg   3120

ccttttgctt gtcaggtttg gatagaatat aattgattgg tttgttactt ggactaacaa   3180

ggcagtagat ttgcctgtgt ggaatttttt ttcctatttt tcttcttttt gctttttttg   3240

cacttatcag aaatatttga tgtgtgcatt gttgaaaaat actggataca tgtcttgtca   3300

gaattgtcgt attaagtaat gtctttccct cttgcttctt tggcaaatgt tgatacacag   3360

tgtttggact tactgaagag ttactgaagc ctgtgggact taataaatac aatatgctac   3420

tccctgttgt gattgaacaa tacaaataac aaacaagaaa gacaatgcat tccattagtc   3480

tgctattctg tttccttcaa cttcatacat agattcatat atgaagtact gcattgtaaa   3540

acaactatag actcatatta aatgttattt ctatttataa tattcagcaa aagtgaaaga   3600

cttgtgaagc atatgacatt ctatttttga cttattagtc ctagtgtgaa agcattaata   3660

ttattagcat gaaattttta cttcagattt taagctcatg aataaagata tatctgtgtt   3720

gatctctaga tatttttagt aatacccaaa tatattcagt ccttattgtt ttaatataag   3780

ctttctgtgt tcagtataat tttatttttc tcaaccttaa atatgaactt aggaaataag   3840

gagggaagta caaagattat tgactataca acctaccagc tgaaagaaag atcttcatca   3900

acatctgtat ctttccagag gtatacagaa ttaaaatttg atcttcaagc tttaatgatc   3960

cagttttaag tcaacggcag aagtatgttg aatatttcat cactcaatct tgaactgatt   4020

tagaagagac tctttgctga aattgaattg cacttataca tgtaaattgt caacatgtaa   4080

tttggaattt tctgattaat aaatgtggtt ttggacatct tttcgggtat agtgacaatg   4140

gaaaatagtt taaactttag gaatagagta ggtaatgtta tagataatca aaagcaattg   4200

taattgtaaa gctgctgtaa tctagtgatc tctagttaca gtgaggaacg ctatgattgg   4260

atgagatgtt tgataaaagt aaaatgtgta tgaaattaca tataaacaga ttattagctt   4320

attgaaagat ctcataacat tggaggaaaa atattcataa tctttagcaa aactagtaga   4380

cttttgttta aaagaataag ataggactag ttgtcactat attagcttaa ggaaatgttg   4440

gtaattatta ctgttgctga actctggctg cttttaagca aaatgacaga ttgccatttt   4500

ctaagtggaa tatactaatc cattagacca tggccctctt ttaatattta gtgagaaatt   4560

actcgcagtt gctttatttt aggttttttg agaaactctt aggccttgtt ttggtatcac   4620

tgttaatcaa aatccttttc actttgattc caattataat actatattat catcattttc   4680

catcttgcat tttcagtggt ggtggatatt ctattccaca tttggtgcta gtcctaagaa   4740

tctttgtcac atgttataca tatagactgc aaaattcata agatataggt cctgcaaaaa   4800

gtatagttga agtaagaaaa cttgaagtaa ctagaataga atactttctc ctaataatct   4860

cttaaatgct ctcatatcca cagtataaaa ttattccgtg tccataatcg gtccaactac   4920

tataaggaga aaattgatgt gtgcttaaga aaatatgtac taaatgattc atatttcaca   4980

gacctacata agaaaaaaat ggcacatcag gtaaatgata gttgtttatc acacagtagg   5040

gaaaggaaga aacatgaaaa tatcaggaag gagatgaaat gtctctgaaa tacaggaaga   5100

atgacataat agcaagtagt ggttctcaaa cgttgtgcat tggaatcaca ggaaggattt   5160

gtaaaaacac aggtgactac cctattcctc tcctggatct gccctctgcc cactttactc   5220

cctccccctt caccctggag tttctgattt agtagaaaat ttgcatttct aacaagttcc   5280

cagctgatgc tgatgctact ggcctggaac accacattaa gaaccattca taggtagtat   5340

tttttttaaa acatcgttgt gttgtgctta acattgattg ataaaggaat gtgcttttaa   5400

catctcctta aaaggtccct tagatttcct ctagataaaa gaattagtaa tttcatctgc   5460

aacacataca atttttttta attttataaa atttagttaa atgtttgttt tacactgact   5520

atggaaacag cactatttta gatacagaaa gaaatcaata aacatagcct gtgttcacaa   5580

ttcactcatc cttttgttat aaaaagactt gaaattaggg ttatgtttta acatgaaaac   5640

aaaatttagc cttagctttt atccatctta actttagaaa ttatatttat gcattgttta   5700

tagatcattg tcattcgttg ttgcttaagt gttcatctga ttttatattt atgatgttaa   5760

aaatagactg ctgaccaata aataataaaa tatttacact ccattctatt tccctgtatt   5820

cacatcctat taatgaaaa                                                5839


<210>  3593
<211>  573
<212>  PRT
<213>  Homo sapiens

<400>  3593

Met Asp His Ile Leu Ile Cys Cys Val Cys Leu Gly Asp Asn Ser Glu 
1               5                   10                  15


Asp Ala Asp Glu Ile Ile Gln Cys Asp Asn Cys Gly Ile Thr Val His 
            20                  25                  30


Glu Gly Cys Tyr Gly Val Asp Gly Glu Ser Asp Ser Ile Met Ser Ser 
        35                  40                  45


Ala Ser Glu Asn Ser Thr Glu Pro Trp Phe Cys Asp Ala Cys Lys Cys 
    50                  55                  60


Gly Val Ser Pro Ser Cys Glu Leu Cys Pro Asn Gln Asp Gly Ile Phe 
65                  70                  75                  80


Lys Glu Thr Asp Ala Gly Arg Trp Val His Ile Val Cys Ala Leu Tyr 
                85                  90                  95


Val Pro Gly Val Ala Phe Gly Asp Ile Asp Lys Leu Arg Pro Val Thr 
            100                 105                 110


Leu Thr Glu Met Asn Tyr Ser Lys Tyr Gly Ala Lys Glu Cys Ser Phe 
        115                 120                 125


Cys Glu Asp Pro Arg Phe Ala Arg Thr Gly Val Cys Ile Ser Cys Asp 
    130                 135                 140


Ala Gly Met Cys Arg Ala Tyr Phe His Val Thr Cys Ala Gln Lys Glu 
145                 150                 155                 160


Gly Leu Leu Ser Glu Ala Ala Ala Glu Glu Asp Ile Ala Asp Pro Phe 
                165                 170                 175


Phe Ala Tyr Cys Lys Gln His Ala Asp Arg Leu Asp Arg Lys Trp Lys 
            180                 185                 190


Arg Lys Asn Tyr Leu Ala Leu Gln Ser Tyr Cys Lys Met Ser Leu Gln 
        195                 200                 205


Glu Arg Glu Lys Gln Leu Ser Pro Glu Ala Gln Ala Arg Ile Asn Ala 
    210                 215                 220


Arg Leu Gln Gln Tyr Arg Ala Lys Ala Glu Leu Ala Arg Ser Thr Arg 
225                 230                 235                 240


Pro Gln Ala Trp Val Pro Arg Glu Lys Leu Pro Arg Pro Leu Thr Ser 
                245                 250                 255


Ser Ala Ser Ala Ile Arg Lys Leu Met Arg Lys Ala Glu Leu Met Gly 
            260                 265                 270


Ile Ser Thr Asp Ile Phe Pro Val Asp Asn Ser Asp Thr Ser Ser Ser 
        275                 280                 285


Val Asp Gly Arg Arg Lys His Lys Gln Pro Ala Leu Thr Ala Asp Phe 
    290                 295                 300


Val Asn Tyr Tyr Phe Glu Arg Asn Met Arg Met Ile Gln Ile Gln Glu 
305                 310                 315                 320


Asn Met Ala Glu Gln Lys Asn Ile Lys Asp Lys Leu Glu Asn Glu Gln 
                325                 330                 335


Glu Lys Leu His Val Glu Tyr Asn Lys Leu Cys Glu Ser Leu Glu Glu 
            340                 345                 350


Leu Gln Asn Leu Asn Gly Lys Leu Arg Ser Glu Gly Gln Gly Ile Trp 
        355                 360                 365


Ala Leu Leu Gly Arg Ile Thr Gly Gln Lys Leu Asn Ile Pro Ala Ile 
    370                 375                 380


Leu Arg Ala Pro Lys Glu Arg Lys Pro Ser Lys Lys Glu Gly Gly Thr 
385                 390                 395                 400


Gln Lys Thr Ser Thr Leu Pro Ala Val Leu Tyr Ser Cys Gly Ile Cys 
                405                 410                 415


Lys Lys Asn His Asp Gln His Leu Leu Leu Leu Cys Asp Thr Cys Lys 
            420                 425                 430


Leu His Tyr His Leu Gly Cys Leu Asp Pro Pro Leu Thr Arg Met Pro 
        435                 440                 445


Arg Lys Thr Lys Asn Ser Tyr Trp Gln Cys Ser Glu Cys Asp Gln Ala 
    450                 455                 460


Gly Ser Ser Asp Met Glu Ala Asp Met Ala Met Glu Thr Leu Pro Asp 
465                 470                 475                 480


Gly Thr Lys Arg Ser Arg Arg Gln Ile Lys Glu Pro Val Lys Phe Val 
                485                 490                 495


Pro Gln Asp Val Pro Pro Glu Pro Lys Lys Ile Pro Ile Arg Asn Thr 
            500                 505                 510


Arg Thr Arg Gly Arg Lys Arg Ser Phe Val Pro Glu Glu Glu Lys His 
        515                 520                 525


Glu Glu Arg Val Pro Arg Glu Arg Arg Gln Arg Gln Ser Val Leu Gln 
    530                 535                 540


Lys Lys Pro Lys Ala Glu Asp Leu Arg Thr Glu Cys Ala Thr Cys Lys 
545                 550                 555                 560


Gly Thr Gly Asp Asn Glu Asn Leu Val Arg Tyr Pro Ser 
                565                 570


<210>  3594
<211>  1248
<212>  DNA
<213>  Homo sapiens

<400>  3594
cagattctga agggagtggt aatggaagtg aagatgcttc aaaggacagt ggagaaggtt     60

cctgtagtga ttctgaagaa aatattttag aagaagaact gaatgaagat attaaagtaa    120

aagaagaaca acttaaaaat tctgcagagg aagaagtact atcatcagaa aaacaattaa    180

ttaaaatgga aaagaaggaa gaagaagaaa atggagaaag acctagaaag aaaaaggaga    240

aagagaagga aaaagaaaag gaaaaggaga aagagaagga aagagagaag gaaaaagaaa    300

aagcaacagt atctgagaat gtggctgctt ctgctgctgc caccacacca gccacaagtc    360

ctcctgctgt taacacatcc ccttctgttc ccactacgac aaccgctaca gaggaacaag    420

tcagcgagcc aaaaaaatgg aaccttcgac gaaaccgacc acttctggat tttgtgtcca    480

tggaagagct gaatgacatg gatgactatg acagtgagga tgacaatgat tggcgaccta    540

ctgtagtaaa gagaaaaggg agatctgcgt ctcagaaaga gggaagtgat ggagacaatg    600

aggatgatga agatgaggga agcgggagtg atgaagacga gaatgatgaa ggcaatgatg    660

aagatcatag tagccctgcc agtgaagggg gttgcaagaa gaagaagagt aaagttctta    720

gcagaaacag tgctgatgat gaggaactga ccaatgatag cctgacccta tctcaaagca    780

agagtaatga ggactcgctg attcttgaga agagtcaaaa ctggagctct caaaaaatgg    840

accatattct gatttgctgt gtttgtctgg gagataatag tgaggacgct gatgaaataa    900

ttcagtgtga caattgtggc attacagtcc atgaaggttg ttatggagtt gatggagaga    960

gtgactctat tatgagttca gcttctgaaa actccactga accttggttt tgtgatgcct   1020

gtaaatgtgg tgtttctcct agctgtgaac tgtgtcctaa tcaggatgga attttcaagg   1080

agacagatgc tggaaggtta atgtcctaat tatgttggtt catatgtttg ctttataatg   1140

tgtctgcctt tgacttccct gttcttctgt ttatgattac acactttcat ttgattgctt   1200

ctttgtatct tcttggcata gaataaatga ccagtgggat acagatgg                1248


<210>  3595
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  3595

Met Glu Lys Lys Glu Glu Glu Glu Asn Gly Glu Arg Pro Arg Lys Lys 
1               5                   10                  15


Lys Glu Lys Glu Lys Glu Lys Glu Lys Glu Lys Glu Lys Glu Lys Glu 
            20                  25                  30


Arg Glu Lys Glu Lys Glu Lys Ala Thr Val Ser Glu Asn Val Ala Ala 
        35                  40                  45


Ser Ala Ala Ala Thr Thr Pro Ala Thr Ser Pro Pro Ala Val Asn Thr 
    50                  55                  60


Ser Pro Ser Val Pro Thr Thr Thr Thr Ala Thr Glu Glu Gln Val Ser 
65                  70                  75                  80


Glu Pro Lys Lys Trp Asn Leu Arg Arg Asn Arg Pro Leu Leu Asp Phe 
                85                  90                  95


Val Ser Met Glu Glu Leu Asn Asp Met Asp Asp Tyr Asp Ser Glu Asp 
            100                 105                 110


Asp Asn Asp Trp Arg Pro Thr Val Val Lys Arg Lys Gly Arg Ser Ala 
        115                 120                 125


Ser Gln Lys Glu Gly Ser Asp Gly Asp Asn Glu Asp Asp Glu Asp Glu 
    130                 135                 140


Gly Ser Gly Ser Asp Glu Asp Glu Asn Asp Glu Gly Asn Asp Glu Asp 
145                 150                 155                 160


His Ser Ser Pro Ala Ser Glu Gly Gly Cys Lys Lys Lys Lys Ser Lys 
                165                 170                 175


Val Leu Ser Arg Asn Ser Ala Asp Asp Glu Glu Leu Thr Asn Asp Ser 
            180                 185                 190


Leu Thr Leu Ser Gln Ser Lys Ser Asn Glu Asp Ser Leu Ile Leu Glu 
        195                 200                 205


Lys Ser Gln Asn Trp Ser Ser Gln Lys Met Asp His Ile Leu Ile Cys 
    210                 215                 220


Cys Val Cys Leu Gly Asp Asn Ser Glu Asp Ala Asp Glu Ile Ile Gln 
225                 230                 235                 240


Cys Asp Asn Cys Gly Ile Thr Val His Glu Gly Cys Tyr Gly Val Asp 
                245                 250                 255


Gly Glu Ser Asp Ser Ile Met Ser Ser Ala Ser Glu Asn Ser Thr Glu 
            260                 265                 270


Pro Trp Phe Cys Asp Ala Cys Lys Cys Gly Val Ser Pro Ser Cys Glu 
        275                 280                 285


Leu Cys Pro Asn Gln Asp Gly Ile Phe Lys Glu Thr Asp Ala Gly Arg 
    290                 295                 300


Leu Met Ser 
305


<210>  3596
<211>  14041
<212>  DNA
<213>  Homo sapiens

<400>  3596
ccggcctcgc gttccctcgg acggttgccc aatggcagcc caggtggcag cccgggaggc     60

gcgagacttc agagaagccc cgacccttcg cctaacctcg ggggccggcc tggaggcagt    120

gggcgctgtg gagctcgagg aggaggagga gaacgaggag gaggcggcgg ccaggagagc    180

gcggagtttc gcccaagacg cgcgggtgcg cttcctcggc ggccgcctgg cgatgatgct    240

ggggttcacg gaggagaaat ggagccagta tttggaaagc gaggacaacc ggcaggttct    300

tggggagttt ctggaaagca ccagcccggc ttgccttgtg tttagcttcg ccgcctcggg    360

gcgccttgcg gcttcccagg agattccaag agatgcaaac cataaacttg tttttatttc    420

caagaagatt actgaaagca ttggagtaaa tgacttttct caagtggttt tatttggaga    480

gttacctgcg ttgtctcttg gacatgtatc tgctttcctt gatgagattt tagtgccagt    540

tctttctaat aagaacaacc ataagtcctg gtcctgtttt acttcacaag atatggaata    600

tcacatagaa gtcatgaaaa agaagatgta tatttttagg ggcaaaatgt ctagaagaac    660

tcttctacca attcccactg ttgcaggaaa gatggatctg gatcagaatt gttcagagaa    720

caagccaccg tcaaacgaaa ggataatact tcatgcaatt gaatctgtgg ttattgaatg    780

gtcacatcaa atccaagaaa ttatagaaag agattcagtg cagcgtttgt tgaatggtct    840

tcacttgtct cctcaagcag aactagattt ctggatgatg aggagagaaa atctgtcatg    900

catttatgat caacttcagg cacctgttgt cctcaaaatg gttaagatcc tgacaactaa    960

acaaagcagc tattttccta ctctgaagga catttttctg gctgtggaaa atgctcttct   1020

cgaagcccaa gatgtggaac tttacctgag acctctgagg agacacatcc agtgtctcca   1080

ggagacggaa ttcccacaga cacgcatatt aatcgctcca ttatttcata ccatctgtct   1140

gatctggagt cattccaagt tttataacac cccagctcgg gttatagttt tattgcaaga   1200

gttttgtaat ctcttcatta accaggcaac agcttacctt tcacctgagg accttttgag   1260

gggagaaata gaagagtcac tggaaaaggt gcaggtggct gttaacatct taaagacttt   1320

caaaaactcc tttttcaact atagaaaaaa attggcaagc tactttatgg gaagaaagct   1380

gagaccatgg gatttccagt ctcatctggt gttttgcaga tttgacaagt ttcttgatcg   1440

tttaataaaa atagaggata tatttgccac cactttggaa tttgaaaagc tggaaagact   1500

ggaatttggt ggtaccaaag gagcaatttt aaatggacaa gtccacgaga tgagtgaaga   1560

acttatggaa ctctgtaaac tttttaaaca gagcacttat gacccatctg attgcactaa   1620

catggagttt gaaagtgatt atgtggcatt taagtccaaa actctggaat ttgacagaag   1680

gcttgggaca attatttgtg aagctttctt taactgcaat ggcttagaag ctgcatttaa   1740

gcttttgacc atatttggaa attttctaga gaagccagtt gtcatggaaa ttttcagcct   1800

acattacagc acactagtgc atatgtttaa tacagagctg gatgtgtgta agcaactgta   1860

taatgaacac atgaaacaga ttgaatgtgg tcatgtagtt cttaacaaga acatgccatt   1920

tacctcagga aatatgaaat gggcccagca ggttctccaa cgacttcaaa tgttttggtc   1980

aaacttcgca tctctccgtt atctattttt gggcaatcct gatcacgctt tagtttatca   2040

aaagtatgtt gaaatgacca ctttgcttga tcaatttgaa agtcgtatct ataatgaatg   2100

gaaaagtaat gtggatgaaa tctgtgaatt caatttgaat caacccttgg ttaaattcag   2160

tgccataaat ggtcttctct gtgtcaattt tgacccaaag ctagtggctg tattgagaga   2220

agtgaaatat cttttgatgt tgaagaaaca agacatacca gattcagctt tagccatctt   2280

caagaaaagg aacactattt taaagtacat tggaaatctt gaccttcttg tgcaagggta   2340

taataaactc aaacagacgc tcctggaagt tgaataccct ctgattgaag atgagctgag   2400

ggctattgac gagcagctga cagcagccac aacgtggctg acatggcagg atgactgctg   2460

gggctacatc gagagggtga gggcagccac gtccgagttg gagcacagag ttgagcgcac   2520

acagaaaaac gtgaaggtga tccagcagac catgaggggc tgggccaggt gcgtgctacc   2580

tcccaggaga gagcacagac gagaggcagc cttcaccttg gaggacaagg gtgatttgtt   2640

tacaaaaaaa tacaagttaa tccaaggaga tggctgcaag atccacaact tggtcgagga   2700

aaataggaag ctcttcaaag ccaatccctc tctggatacc tggaaaattt atgtagaatt   2760

cattgacgac attgtggtgg aaggcttttt tcaggctata atgcacgact tagacttctt   2820

tctgaagaat acagagaaac aattgaaacc ggcaccgttt tttcaagcac aaatgatctt   2880

gttgcctcct gagattgtgt ttaaaccttc cctagacaga gaggctgggg atggcttcta   2940

tgatcttgta gaagaaatgt tatgcaatag ttttagaatg tctgcccaga tgaaccgaat   3000

agcaacacac ctggaaatta aaaattatca gaatgatatg gataacatgt taggcctggc   3060

agaggtcagg caggagatca tgaacagagt ggtgaatgtc atcaacaaag tcttagattt   3120

cagaaacacc ctggagaccc acacttacct ctgggtggat gatcgagctg agtttatgaa   3180

gcattttctc ttgtatggcc atgctgtgtc ttccgatgaa atggatgctc atgcaaatga   3240

agaaattccc gaacaaccac caactcttga gcaattcaaa gaacagattg acatttatga   3300

agctttgtat gttcaaatga gcaaatttga ggactttaga gtgtttgata gttggttcaa   3360

ggtggacatg aagcctttca aagtgagctt gttaaccata attaagaaat ggagctggat   3420

gtttcaggag catcttttga gatttgtcat tgacagtctg aatgagctac aagaatttat   3480

aaaggagaca gattccggac ttcagagaga attaaatgaa ggtgatcatg atggtttagt   3540

tgacatcatg gtgcatcttc tggctgtaag aagccgacag agagctactg atgaactctt   3600

tgaacctcta aaagaaacga tcaccctctt ggaaagctat ggccagaaga tgcctgagca   3660

ggtctatatt cagctagagg aattacctga aagatgggaa actaccaaaa agatcgcagc   3720

aactgtcaga catgaagtct cacctctcca taatgcggaa gtcactctta taaggaaaaa   3780

atgtattttg tttgacgcaa agcaggcaga gttcagagag agattcagac actatgcccc   3840

tcttggattt aatgcagaaa atccatacac agcgcttgat aaggcaaatg aagagcttga   3900

ggccttagaa gaagaaatgt tgcagatgca agaatctact cgtctttttg aagtggctct   3960

tccagagtac aaacaaatga aacagtgtcg caaagaaata aaattgctca agggactgtg   4020

ggatgtcatt atttatgttc gaagaagcat tgataattgg actaaaaccc agtggagaca   4080

gattcatgtg gaacagatgg atgtagaact cagaaggttt gccaaggcga gttccataac   4140

tgaaatttgg tcactcaaca aggaagtccg cgtctgggat gcttacacgg gcctggaagg   4200

cacagttaag gacatgacag cctccctgag ggccatcaca gagttacaga gccctgccct   4260

cagggacagg cattggcacc agctgatgaa agctattggg gtcaagtttt taataaatga   4320

agccacaact ttggcagatt tgttagcact gcggttacac agagtggaag atgatgtccg   4380

aaggattgtg gacaaggcgg tgaaagagct ggggactgag aaggttatta ctgaaatcag   4440

tcagacctgg gcaaccatga agttttctta cgaagttcac tatcgaacag gcattccatt   4500

actaaagtct gatgaacaac tttttgaaac tctagagcac aaccaagttc agttgcagac   4560

tcttcttcaa agcaagtatg tagaatattt cattgagcaa gtgttaagct ggcaaaataa   4620

attaaacata gcagacttgg tcatcttcac ttggatggaa gtccagcgaa cttggtctca   4680

cctggaaagc atttttgtct gttcagaaga tattcgaatc cagcttgtga aagatgctag   4740

aagatttgat ggggtggatg ctgaatttaa ggagttaatg ttcaagacag ccaaagtaga   4800

aaatgtgtta gaagcaacgt gcagacctaa tctctatgaa aaacttaaag atttacagtc   4860

caggctttct ctttgtgaaa aagctctcgc tgaatacctg gaaaccaagc gcatagcctt   4920

tcctcgcttc tatttcgtct cttctgctga tttacttgac attctctcaa aaggagctca   4980

gcctaaacag gtaacatgtc accttgccaa acttttcgac agcattgcag atctgcagtt   5040

tgaagacaat caggatgttt ctgcacacag ggcagttgga atgtacagca aagaaaagga   5100

gtatgtccca ttccaagccg agtgtgaatg tgtgggccat gtggaaacat ggcttctgca   5160

acttgaacag actatgcaag aaacggtgcg tcattctata acagaagcca tagtggccta   5220

cgaggaaaaa cctagggaac tgtggatttt tgatttccca gctcaggttg cactaaccag   5280

ctcacaaata tggtggacca cagatgtagg aatagccttc agtagactgg aagaaggcta   5340

cgaaacagcc ctgaaggatt tccataaaaa acagatttct cagctgaata cactgattac   5400

acttttgctg ggagaacttc cacctggaga cagacagaag atcatgacaa tttgtaccat   5460

agatgtccat gccagagacg tggtggcaaa acttatttct cagaaggcaa gttgttgtca   5520

gtccccaagc ttttacatgg ctgtctcaac ttcgtcaccg atgggaggat acccagaaac   5580

actgctttgt taatatttgt gatgcccagt tccagtactt ctatgaatac ttaggaaaca   5640

gccctcgact agtgatcact cctctaactg acaggtgtta tattacctta actcaatcac   5700

ttcatctaac catgagtggg gctcctgctg gcccagctgg taccgggaaa acagagacca   5760

ccaaagacct aggacgtgcc cttggcatga tggtctatgt attcaactgt tcagagcaaa   5820

tggactacaa atccataggc aatatctata agggattggt gcagacagga gcttggggct   5880

gctttgatga gttcaaccga atctctgtgg aagttctgtc agtggtggca gtacaagtga   5940

aaatgattca tgatgccatc agaaacagga agaagagatt tgtatttctt ggggaagcta   6000

tcacactgaa gccatcagtt ggaatattta ttactatgaa cccgggttat gctggtcgaa   6060

ccgaattacc ggaaaatctc aaagctcttt tcagaccctg tgccatggtg gcccctgaca   6120

ttgagctaat ctgtgaaatc ttgttagttg ctgaaggttt tgtggatgcg cgtgcattag   6180

cccgaaagtt cattacgttg tacacgcttt gcaaggagct tctctccaag caggatcatt   6240

acgactgggg acttcgtgct attaagtctg tcttggttgt ggctggatct ctgaaacgag   6300

gagataaaaa tagacccgaa gatcaggtac tcatgagagc attaagggat ttcaatatgc   6360

ccaaaatagt gactgacgac atcccagtgt ttctgggcct ggtcggtgac ctgtttccag   6420

ccctggatgt gccccggagg aggaagctgc actttgaaca gatggtcagg cagtctaccc   6480

tggagctccg cctgcagcct gaagagagct tcatcctcaa agttgtccag cttgaggaac   6540

tgttggctgt gcggcactcg gtctttgtag ttggaaatgc aggcacagga aagagtaaga   6600

ttttgagaac actgaaccga acatatgtta acatgaaaca gaagccggtt tggaatgact   6660

taaaccctaa agctgtgaca acagatgaac tctttggttt catacatcat gctacccgag   6720

aatggaaaga tggcaagatt gtttactctt attttatagg tctcttctca tccattctac   6780

gagaacaagc aaatcttaag catgatggac caaaatggat agtcctggat ggcgatattg   6840

accccatgtg gattgaatca ctgaatactg taatggatga taacaaggtg ctgaccctcg   6900

ccagcaatga gcgcattgca ctcactccct tcatgaggct tctgtttgag atacatcact   6960

taaggagcgc aaccccggcc actgtttcca gagctggtat tctgtatgtg aacccacaag   7020

atctgggctg gaatccgtat gtggccagtt ggatagacag aaggcggcat caatcagaaa   7080

aggccaattt gactattctt tttgataaat atgtccctgc atgcttggat aaactgagaa   7140

caagctttaa aaccatcact tcaattcctg agagtagcct ggtgcagact ctatgtgttc   7200

ttttggagtg cttgctgact cctgaaaatg taccttctga cagcccaaaa gaagtttatg   7260

aagtctattt tgtatttgct tgtatctggg cttttggagg caccctgcta caagatcaga   7320

tttctgatta tcaagctgac ttcagtcggt ggtggcagaa agagatgaaa gcagtgaaat   7380

ttccgtcgca gggaacaatc tttgattatt atgtggacca caaaactaag aaattattgc   7440

cctgggctga caaaattgcc cagtttacta tggatccaga tgtgcctctg cagacagttc   7500

tcgttcacac aacagagaca gctcgtctta gatatttcat ggagttgttg cttgagaaag   7560

gaaaacctct aatgctagta ggaaatgcag gagtgggaaa aacagtcttt gtaggtgaca   7620

cattggcaag tctctctgag gattacatag tatcccgtgt gcctttcaac tactacacga   7680

catccacagc tctgcaaaaa attcttgaga aacccctaga gaaaaaagct ggtcataact   7740

atggtcctgg aggaaataaa aaattgattt attttatcga cgacatgaac atgcctgaag   7800

tggacttata tggcaccgtt cagcctcaca ccctgatccg gcagcatatt gattatggac   7860

attggtatga tagacagaag gtgatgctta aagaaatcca taactgccag tatgtcgcct   7920

gcatgaatcc gatggtgggc agcttcacca tcaatcccag gctacagaga catttcacag   7980

tgtttgcatt caattttcca tctttggatg cactaaacac catctatggc caaatcttta   8040

gcttccattt ccaacagcaa gcatttgctc catcaattct caggagtggc cccactttga   8100

tccaggcaac aatagcattc catcagacaa tgatgtgtaa ctttttaccc acggctatta   8160

aattccacta catctttaat ctgagagatt tatcaaacgt cttccagggg attttatttg   8220

cttctcctga gtgtttaaaa ggtccacttg atttaataca tctgtggctt catgaatctg   8280

cccgtgttta tggagacaaa ctgatagaca aaaaagattg tgatttgttt cagagaagaa   8340

tgctggaaac tgcttataaa tattttgaag gtatagatag tcacatgctg cttcaacagc   8400

ccctcattta ttgccacttt gctgatagag ggaaggaccc acattacatg ccagtgaagg   8460

actgggaagt gctgaagacg attcttacag aaacgttaga caactacaat gaactaaatg   8520

ctgccatgca cctagttttg tttgaagatg ccatgcaaca tgtgtgtcgc atcagccgga   8580

tcttacgaac ccctcagggc tgtgctctct tggttggagt tgggggcagt ggcaagcaga   8640

gcttgtccag gctggcagct taccttcgtg gccttgaggt ctttcagatc actctgaccg   8700

agggctatgg aatccaggaa cttcgggtag atcttgccaa tttgtacatc cgaactggag   8760

ccaagaacat gcccactgtg ttcctgctga cagatgccca ggttctagat gagagcttcc   8820

tcgtgctgat taatgacttg ctggcatcag gagaaatccc agatctgttc agcgatgaag   8880

atgtggacaa gataatttct ggaattcata atgaagttca tgctctgggc atggtagact   8940

ccagggaaaa ctgttggaaa ttctttatgg ccagggtgcg actacagctc aaaatcattt   9000

tgtgtttctc tccagttggt cgcacgctga gagttagagc tcggaagttc ccagccatag   9060

ttaactgcac ggctattgac tggtttcatg cgtggccgca ggaggctctg gtctccgtca   9120

gcaggaggtt cattgaggaa accaagggaa ttgagccagt gcacaaagac tctattagcc   9180

ttttcatggc acatgttcac accactgtaa atgaaatgag taccagatat taccagaatg   9240

agagaagaca caactatacc accccaaaga gttttctaga acaaatatca ctgtttaaga   9300

acctgttgaa gaagaagcaa aatgaggtat ccgagaaaaa agaacgcctg gtgaacggca   9360

tccaaaagct aaaaaccaca gcctctcagg tgggagatct aaaagccaga cttgcctctc   9420

aagaagccga gctgcaactg agaaatcatg atgccgaagc tctgatcaca aagatcggcc   9480

ttcagacgga gaaagtgagc cgggaaaaga ccatcgctga tgctgaggag cgaaaggtga   9540

cagccattca gactgaagtg ttccagaaac agagagaatg tgaagctgac ttactcaagg   9600

ctgagcctgc actggtggct gctacagctg cactcaatac actcaacagg gtcaacctca   9660

gtgagctgaa agcctttccc aaccctccca tcgcagttac caatgttact gcagccgtga   9720

tggtccttct ggctcctcgg ggaagagtgc ccaaagaccg aagttggaaa gcagctaaag   9780

tcttcatggg aaaggttgat gattttttgc aagcattaat taactatgac aaagagcaca   9840

ttccagagaa ctgtctaaaa gtggtgaatg aacactattt gaaagaccca gagtttaatc   9900

caaacctgat tcgaaccaaa tcttttgcag cagctggcct gtgtgcctgg gtcatcaaca   9960

tcattaaatt ctatgaggtc tactgtgatg tggagccaaa acgccaagca ttagcccaag  10020

caaacttaga actggctgca gctactgaaa aactagaggc tatcaggaaa aagcttgtgg  10080

atctggatcg aaatctgagc agactcacgg cttcatttga aaaagcaaca gctgagaaag  10140

tccggtgtca agaagaggtg aaccaaacca acaaaaccat caaattagct aacagacttg  10200

tcaaggaact tgaggcaaag aagattcgct ggggtcaatc cattaagtcc tttgaagctc  10260

aagagaagac actctgtgga gatgttcttc tcacggcggc atttgtgtct tacgtcggac  10320

ccttcacaag gcagtatcgc caggagctgg tgcactgcaa gtgggttccc tttcttcaac  10380

agaaggtttc cattccacta accgaaggcc tggacttgat atccatgttg acggatgatg  10440

ctacaattgc cgcctggaat aacgaaggac tgcccagtga cagaatgtcc accgaaaatg  10500

ccgctatcct aacacactgt gagcgctggc ctctggtgat agatccccag caacagggaa  10560

ttaagtggat caagaataag tatggaatgg acctgaaagt cacacatttg ggccagaaag  10620

ggtttttgaa tgccattgaa actgctttgg cctttggtga tgtcatctta attgaaaatc  10680

tcgaggaaac gatagatcca gtcctggatc cactacttgg caggaacaca attaaaaaag  10740

gaaagtatat caggattgga gataaagaat gtgaatttaa caagaacttt cgccttatcc  10800

ttcacacaaa attggcaaat cctcactata agccggaatt acaagctcag acaactctcc  10860

tcaatttcac agtcacagaa gatggtctag aagcccagct gctggcagag gttgtcagta  10920

ttgaaaggcc agatttggag aaacttaagt tggtattgac aaagcaccaa aatgatttta  10980

aaattgagct caagtatctg gaagacgatc tccttttgcg cctttctgcg gcagagggaa  11040

gctttctgga tgacaccaaa ctggtagaga gattggaggc aacaaagacc accgtggcag  11100

agatagagca caaggtgatt gaagccaaag aaaatgaaag aaaaatcaac gaggcccgag  11160

aatgttacag accagtggca gcaagagcat ctcttcttta ttttgttatt aatgacctcc  11220

aaaaaatcaa ccccctctac caattctctt tgaaggcttt taacgtgctg ttccacagag  11280

cgatcgagca ggctgacaag gtggaagaca tgcagggacg catctctatc ctgatggaga  11340

gcatcaccca tgctgtcttc ctctacacca gccaggcgct gtttgagaag gacaagctca  11400

ccttcctgtc ccagatggct tttcagattt tgttgagaaa gaaagagata gaccctcttg  11460

aattggattt cctgcttcga ttcacagttg aacacactca tctgagtccc gttgacttcc  11520

taacttctca gtcatggagt gctatcaagg caattgccgt catggaagaa tttcgaggca  11580

tagaccgaga tgtggaagga tctgccaagc agtggaggaa gtgggtagaa tccgagtgtc  11640

cagaaaaaga aaaattacct caagaatgga agaagaaaag tttaatacag aagctgattc  11700

ttctgagagc aatgcgccct gacagaatga cgtatgctct cagaaatttt gtagaggaaa  11760

aactgggtgc gaagtatgtg gagaggacca gattggactt agttaaagca ttcgaagaaa  11820

gcagcccagc cacccccata ttcttcatcc tgtctccggg ggtagatgcc cttaaagacc  11880

tggagattct tggcaaaaga cttggcttta caattgactc tggaaaattc cacaatgtgt  11940

ctttaggaca aggtcaggag acggtggcag aagtggccct ggagaaagct tccaaaggag  12000

gacactgggt catcctccaa aatgttcatt tggtagccaa gtggctagga accttggaga  12060

agctccttga aagattcagc caaggaagcc acagagatta cagggttttc atgagtgctg  12120

agtctgcacc tacaccagat gagcatatca tccctcaagg actcctggaa aattccatta  12180

agatcactaa tgaaccccca acagggatgc tggccaattt gcatgccgcc ctgtacaact  12240

ttgatcagga tacacttgaa atatgctcca aggagcagga gtttaaaagc atcctttttt  12300

ctctctgcta cttccacgcc tgtgttgctg ggagactgag gtttggcccc cagggctgga  12360

gccgaagcta tccttttaat cctggagacc tcaccatttg tgccagtgtc ctctacaact  12420

acttagaggc aaactctaaa gtcccatggg aagatctccg ttatctcttt ggtgagatca  12480

tgtatggagg ccacatcaca gatgactggg atcgcaaact gtgtcgggtg tatttagaag  12540

aattcatgaa tccatctctg actgaagatg aactgatgct ggcaccaggt tttgctgccc  12600

caccctacct agattatgca ggctaccacc agtacataga ggagatgctt cctccagaaa  12660

gcccggcact gtatggcctc cacccaaatg ctgaaataga attcctgaca gtgacatcca  12720

acactctctt cagaactttg ctggagatgc agcccaggaa tgcactcagt ggtgatgaac  12780

tggggcagtc tacagaagaa aaggttaaga atgtcttgga tgacattttg gagaaacttc  12840

cagaagagtt caacatggca gagataatgc aaaaaaattc aaatagaagc ccatatgttc  12900

ttgtttgctt ccaagaatgt gagaggatga atattctcat tcgggaaata cgtatatcac  12960

ttgaacaact ggaccttagt ttgaaggggg aattggcatt atctcctgct gtggaagccc  13020

agcagtttgc attgagttat gacacggtac cagacacttg gagcaaactg gcttatcctt  13080

ctacttatgg cctagcccag tggttcaatg acctcctcct gcgatgccga gaactcgata  13140

cttggacaca agaccttacc cttccggctg tcgtgtggct ctccggcttc ttcaaccctc  13200

agtccttctt aactgcaatc atgcagacga tggctcgaaa aaatgagtgg cccctggata  13260

aaacgcgctt gactgctgat gttaccaaaa aaacaaagga agattatgga cacccgccaa  13320

gggaaggtgc atacctccac ggactcttca tggagggcgc ccgctgggac acccaagcag  13380

gaaccattgt tgaagcccgt ctcaaggagc tggcatgccc tatgccggtc atctttgcaa  13440

aagccacccc cgtggacaga caagaaacca aacagaccta cgagtgccct gtgtatagaa  13500

ccaaactgag aggccccagc tacatctgga ccttcaggct gaagagcgaa gagaagactg  13560

caaaatgggt tctggctgga gtggctctgc ttctagaagc gtaaggtaac actggcattc  13620

ctctagcctc tgctggagtg cagtgaggat tttctagcat gttgctgcac tgttcccatg  13680

cacattattc taacttttta gtaactcaca cgtgcattct tttttcaacg ctatccttag  13740

agtgaaagtc agaaaaaaat actagaaact aactcagggt acatcataaa agtacatcat  13800

atgtgaacat gcaaaagcaa tgcagccgga aagaacggag attttaattt ttaacaaaca  13860

acaaattaaa ttattagccc ttaaactctt tcaaaatata aaagcagcag gccccaggtg  13920

agtcctgaag gaagaggcta gcactctgta aggcctccag tgtccagtgt ctacaatgtt  13980

gatggtcccc ttttgttcag tcaagtttta ataaaaataa aactgttcta cagttaattg  14040

c                                                                  14041


<210>  3597
<211>  2713
<212>  PRT
<213>  Homo sapiens

<400>  3597

Met Ser Met Pro Glu Thr Trp Trp Gln Asn Leu Phe Leu Arg Arg Gln 
1               5                   10                  15


Val Val Val Ser Pro Gln Ala Phe Thr Trp Leu Ser Gln Leu Arg His 
            20                  25                  30


Arg Trp Glu Asp Thr Gln Lys His Cys Phe Val Asn Ile Cys Asp Ala 
        35                  40                  45


Gln Phe Gln Tyr Phe Tyr Glu Tyr Leu Gly Asn Ser Pro Arg Leu Val 
    50                  55                  60


Ile Thr Pro Leu Thr Asp Arg Cys Tyr Ile Thr Leu Thr Gln Ser Leu 
65                  70                  75                  80


His Leu Thr Met Ser Gly Ala Pro Ala Gly Pro Ala Gly Thr Gly Lys 
                85                  90                  95


Thr Glu Thr Thr Lys Asp Leu Gly Arg Ala Leu Gly Met Met Val Tyr 
            100                 105                 110


Val Phe Asn Cys Ser Glu Gln Met Asp Tyr Lys Ser Ile Gly Asn Ile 
        115                 120                 125


Tyr Lys Gly Leu Val Gln Thr Gly Ala Trp Gly Cys Phe Asp Glu Phe 
    130                 135                 140


Asn Arg Ile Ser Val Glu Val Leu Ser Val Val Ala Val Gln Val Lys 
145                 150                 155                 160


Met Ile His Asp Ala Ile Arg Asn Arg Lys Lys Arg Phe Val Phe Leu 
                165                 170                 175


Gly Glu Ala Ile Thr Leu Lys Pro Ser Val Gly Ile Phe Ile Thr Met 
            180                 185                 190


Asn Pro Gly Tyr Ala Gly Arg Thr Glu Leu Pro Glu Asn Leu Lys Ala 
        195                 200                 205


Leu Phe Arg Pro Cys Ala Met Val Ala Pro Asp Ile Glu Leu Ile Cys 
    210                 215                 220


Glu Ile Leu Leu Val Ala Glu Gly Phe Val Asp Ala Arg Ala Leu Ala 
225                 230                 235                 240


Arg Lys Phe Ile Thr Leu Tyr Thr Leu Cys Lys Glu Leu Leu Ser Lys 
                245                 250                 255


Gln Asp His Tyr Asp Trp Gly Leu Arg Ala Ile Lys Ser Val Leu Val 
            260                 265                 270


Val Ala Gly Ser Leu Lys Arg Gly Asp Lys Asn Arg Pro Glu Asp Gln 
        275                 280                 285


Val Leu Met Arg Ala Leu Arg Asp Phe Asn Met Pro Lys Ile Val Thr 
    290                 295                 300


Asp Asp Ile Pro Val Phe Leu Gly Leu Val Gly Asp Leu Phe Pro Ala 
305                 310                 315                 320


Leu Asp Val Pro Arg Arg Arg Lys Leu His Phe Glu Gln Met Val Arg 
                325                 330                 335


Gln Ser Thr Leu Glu Leu Arg Leu Gln Pro Glu Glu Ser Phe Ile Leu 
            340                 345                 350


Lys Val Val Gln Leu Glu Glu Leu Leu Ala Val Arg His Ser Val Phe 
        355                 360                 365


Val Val Gly Asn Ala Gly Thr Gly Lys Ser Lys Ile Leu Arg Thr Leu 
    370                 375                 380


Asn Arg Thr Tyr Val Asn Met Lys Gln Lys Pro Val Trp Asn Asp Leu 
385                 390                 395                 400


Asn Pro Lys Ala Val Thr Thr Asp Glu Leu Phe Gly Phe Ile His His 
                405                 410                 415


Ala Thr Arg Glu Trp Lys Asp Gly Lys Ile Val Tyr Ser Tyr Phe Ile 
            420                 425                 430


Gly Leu Phe Ser Ser Ile Leu Arg Glu Gln Ala Asn Leu Lys His Asp 
        435                 440                 445


Gly Pro Lys Trp Ile Val Leu Asp Gly Asp Ile Asp Pro Met Trp Ile 
    450                 455                 460


Glu Ser Leu Asn Thr Val Met Asp Asp Asn Lys Val Leu Thr Leu Ala 
465                 470                 475                 480


Ser Asn Glu Arg Ile Ala Leu Thr Pro Phe Met Arg Leu Leu Phe Glu 
                485                 490                 495


Ile His His Leu Arg Ser Ala Thr Pro Ala Thr Val Ser Arg Ala Gly 
            500                 505                 510


Ile Leu Tyr Val Asn Pro Gln Asp Leu Gly Trp Asn Pro Tyr Val Ala 
        515                 520                 525


Ser Trp Ile Asp Arg Arg Arg His Gln Ser Glu Lys Ala Asn Leu Thr 
    530                 535                 540


Ile Leu Phe Asp Lys Tyr Val Pro Ala Cys Leu Asp Lys Leu Arg Thr 
545                 550                 555                 560


Ser Phe Lys Thr Ile Thr Ser Ile Pro Glu Ser Ser Leu Val Gln Thr 
                565                 570                 575


Leu Cys Val Leu Leu Glu Cys Leu Leu Thr Pro Glu Asn Val Pro Ser 
            580                 585                 590


Asp Ser Pro Lys Glu Val Tyr Glu Val Tyr Phe Val Phe Ala Cys Ile 
        595                 600                 605


Trp Ala Phe Gly Gly Thr Leu Leu Gln Asp Gln Ile Ser Asp Tyr Gln 
    610                 615                 620


Ala Asp Phe Ser Arg Trp Trp Gln Lys Glu Met Lys Ala Val Lys Phe 
625                 630                 635                 640


Pro Ser Gln Gly Thr Ile Phe Asp Tyr Tyr Val Asp His Lys Thr Lys 
                645                 650                 655


Lys Leu Leu Pro Trp Ala Asp Lys Ile Ala Gln Phe Thr Met Asp Pro 
            660                 665                 670


Asp Val Pro Leu Gln Thr Val Leu Val His Thr Thr Glu Thr Ala Arg 
        675                 680                 685


Leu Arg Tyr Phe Met Glu Leu Leu Leu Glu Lys Gly Lys Pro Leu Met 
    690                 695                 700


Leu Val Gly Asn Ala Gly Val Gly Lys Thr Val Phe Val Gly Asp Thr 
705                 710                 715                 720


Leu Ala Ser Leu Ser Glu Asp Tyr Ile Val Ser Arg Val Pro Phe Asn 
                725                 730                 735


Tyr Tyr Thr Thr Ser Thr Ala Leu Gln Lys Ile Leu Glu Lys Pro Leu 
            740                 745                 750


Glu Lys Lys Ala Gly His Asn Tyr Gly Pro Gly Gly Asn Lys Lys Leu 
        755                 760                 765


Ile Tyr Phe Ile Asp Asp Met Asn Met Pro Glu Val Asp Leu Tyr Gly 
    770                 775                 780


Thr Val Gln Pro His Thr Leu Ile Arg Gln His Ile Asp Tyr Gly His 
785                 790                 795                 800


Trp Tyr Asp Arg Gln Lys Val Met Leu Lys Glu Ile His Asn Cys Gln 
                805                 810                 815


Tyr Val Ala Cys Met Asn Pro Met Val Gly Ser Phe Thr Ile Asn Pro 
            820                 825                 830


Arg Leu Gln Arg His Phe Thr Val Phe Ala Phe Asn Phe Pro Ser Leu 
        835                 840                 845


Asp Ala Leu Asn Thr Ile Tyr Gly Gln Ile Phe Ser Phe His Phe Gln 
    850                 855                 860


Gln Gln Ala Phe Ala Pro Ser Ile Leu Arg Ser Gly Pro Thr Leu Ile 
865                 870                 875                 880


Gln Ala Thr Ile Ala Phe His Gln Thr Met Met Cys Asn Phe Leu Pro 
                885                 890                 895


Thr Ala Ile Lys Phe His Tyr Ile Phe Asn Leu Arg Asp Leu Ser Asn 
            900                 905                 910


Val Phe Gln Gly Ile Leu Phe Ala Ser Pro Glu Cys Leu Lys Gly Pro 
        915                 920                 925


Leu Asp Leu Ile His Leu Trp Leu His Glu Ser Ala Arg Val Tyr Gly 
    930                 935                 940


Asp Lys Leu Ile Asp Lys Lys Asp Cys Asp Leu Phe Gln Arg Arg Met 
945                 950                 955                 960


Leu Glu Thr Ala Tyr Lys Tyr Phe Glu Gly Ile Asp Ser His Met Leu 
                965                 970                 975


Leu Gln Gln Pro Leu Ile Tyr Cys His Phe Ala Asp Arg Gly Lys Asp 
            980                 985                 990


Pro His Tyr Met Pro Val Lys Asp Trp Glu Val Leu Lys Thr Ile Leu 
        995                 1000                1005


Thr Glu Thr Leu Asp Asn Tyr Asn Glu Leu Asn Ala Ala Met His Leu 
    1010                1015                1020


Val Leu Phe Glu Asp Ala Met Gln His Val Cys Arg Ile Ser Arg Ile 
1025                1030                1035                1040


Leu Arg Thr Pro Gln Gly Cys Ala Leu Leu Val Gly Val Gly Gly Ser 
                1045                1050                1055


Gly Lys Gln Ser Leu Ser Arg Leu Ala Ala Tyr Leu Arg Gly Leu Glu 
            1060                1065                1070


Val Phe Gln Ile Thr Leu Thr Glu Gly Tyr Gly Ile Gln Glu Leu Arg 
        1075                1080                1085


Val Asp Leu Ala Asn Leu Tyr Ile Arg Thr Gly Ala Lys Asn Met Pro 
    1090                1095                1100


Thr Val Phe Leu Leu Thr Asp Ala Gln Val Leu Asp Glu Ser Phe Leu 
1105                1110                1115                1120


Val Leu Ile Asn Asp Leu Leu Ala Ser Gly Glu Ile Pro Asp Leu Phe 
                1125                1130                1135


Ser Asp Glu Asp Val Asp Lys Ile Ile Ser Gly Ile His Asn Glu Val 
            1140                1145                1150


His Ala Leu Gly Met Val Asp Ser Arg Glu Asn Cys Trp Lys Phe Phe 
        1155                1160                1165


Met Ala Arg Val Arg Leu Gln Leu Lys Ile Ile Leu Cys Phe Ser Pro 
    1170                1175                1180


Val Gly Arg Thr Leu Arg Val Arg Ala Arg Lys Phe Pro Ala Ile Val 
1185                1190                1195                1200


Asn Cys Thr Ala Ile Asp Trp Phe His Ala Trp Pro Gln Glu Ala Leu 
                1205                1210                1215


Val Ser Val Ser Arg Arg Phe Ile Glu Glu Thr Lys Gly Ile Glu Pro 
            1220                1225                1230


Val His Lys Asp Ser Ile Ser Leu Phe Met Ala His Val His Thr Thr 
        1235                1240                1245


Val Asn Glu Met Ser Thr Arg Tyr Tyr Gln Asn Glu Arg Arg His Asn 
    1250                1255                1260


Tyr Thr Thr Pro Lys Ser Phe Leu Glu Gln Ile Ser Leu Phe Lys Asn 
1265                1270                1275                1280


Leu Leu Lys Lys Lys Gln Asn Glu Val Ser Glu Lys Lys Glu Arg Leu 
                1285                1290                1295


Val Asn Gly Ile Gln Lys Leu Lys Thr Thr Ala Ser Gln Val Gly Asp 
            1300                1305                1310


Leu Lys Ala Arg Leu Ala Ser Gln Glu Ala Glu Leu Gln Leu Arg Asn 
        1315                1320                1325


His Asp Ala Glu Ala Leu Ile Thr Lys Ile Gly Leu Gln Thr Glu Lys 
    1330                1335                1340


Val Ser Arg Glu Lys Thr Ile Ala Asp Ala Glu Glu Arg Lys Val Thr 
1345                1350                1355                1360


Ala Ile Gln Thr Glu Val Phe Gln Lys Gln Arg Glu Cys Glu Ala Asp 
                1365                1370                1375


Leu Leu Lys Ala Glu Pro Ala Leu Val Ala Ala Thr Ala Ala Leu Asn 
            1380                1385                1390


Thr Leu Asn Arg Val Asn Leu Ser Glu Leu Lys Ala Phe Pro Asn Pro 
        1395                1400                1405


Pro Ile Ala Val Thr Asn Val Thr Ala Ala Val Met Val Leu Leu Ala 
    1410                1415                1420


Pro Arg Gly Arg Val Pro Lys Asp Arg Ser Trp Lys Ala Ala Lys Val 
1425                1430                1435                1440


Phe Met Gly Lys Val Asp Asp Phe Leu Gln Ala Leu Ile Asn Tyr Asp 
                1445                1450                1455


Lys Glu His Ile Pro Glu Asn Cys Leu Lys Val Val Asn Glu His Tyr 
            1460                1465                1470


Leu Lys Asp Pro Glu Phe Asn Pro Asn Leu Ile Arg Thr Lys Ser Phe 
        1475                1480                1485


Ala Ala Ala Gly Leu Cys Ala Trp Val Ile Asn Ile Ile Lys Phe Tyr 
    1490                1495                1500


Glu Val Tyr Cys Asp Val Glu Pro Lys Arg Gln Ala Leu Ala Gln Ala 
1505                1510                1515                1520


Asn Leu Glu Leu Ala Ala Ala Thr Glu Lys Leu Glu Ala Ile Arg Lys 
                1525                1530                1535


Lys Leu Val Asp Leu Asp Arg Asn Leu Ser Arg Leu Thr Ala Ser Phe 
            1540                1545                1550


Glu Lys Ala Thr Ala Glu Lys Val Arg Cys Gln Glu Glu Val Asn Gln 
        1555                1560                1565


Thr Asn Lys Thr Ile Lys Leu Ala Asn Arg Leu Val Lys Glu Leu Glu 
    1570                1575                1580


Ala Lys Lys Ile Arg Trp Gly Gln Ser Ile Lys Ser Phe Glu Ala Gln 
1585                1590                1595                1600


Glu Lys Thr Leu Cys Gly Asp Val Leu Leu Thr Ala Ala Phe Val Ser 
                1605                1610                1615


Tyr Val Gly Pro Phe Thr Arg Gln Tyr Arg Gln Glu Leu Val His Cys 
            1620                1625                1630


Lys Trp Val Pro Phe Leu Gln Gln Lys Val Ser Ile Pro Leu Thr Glu 
        1635                1640                1645


Gly Leu Asp Leu Ile Ser Met Leu Thr Asp Asp Ala Thr Ile Ala Ala 
    1650                1655                1660


Trp Asn Asn Glu Gly Leu Pro Ser Asp Arg Met Ser Thr Glu Asn Ala 
1665                1670                1675                1680


Ala Ile Leu Thr His Cys Glu Arg Trp Pro Leu Val Ile Asp Pro Gln 
                1685                1690                1695


Gln Gln Gly Ile Lys Trp Ile Lys Asn Lys Tyr Gly Met Asp Leu Lys 
            1700                1705                1710


Val Thr His Leu Gly Gln Lys Gly Phe Leu Asn Ala Ile Glu Thr Ala 
        1715                1720                1725


Leu Ala Phe Gly Asp Val Ile Leu Ile Glu Asn Leu Glu Glu Thr Ile 
    1730                1735                1740


Asp Pro Val Leu Asp Pro Leu Leu Gly Arg Asn Thr Ile Lys Lys Gly 
1745                1750                1755                1760


Lys Tyr Ile Arg Ile Gly Asp Lys Glu Cys Glu Phe Asn Lys Asn Phe 
                1765                1770                1775


Arg Leu Ile Leu His Thr Lys Leu Ala Asn Pro His Tyr Lys Pro Glu 
            1780                1785                1790


Leu Gln Ala Gln Thr Thr Leu Leu Asn Phe Thr Val Thr Glu Asp Gly 
        1795                1800                1805


Leu Glu Ala Gln Leu Leu Ala Glu Val Val Ser Ile Glu Arg Pro Asp 
    1810                1815                1820


Leu Glu Lys Leu Lys Leu Val Leu Thr Lys His Gln Asn Asp Phe Lys 
1825                1830                1835                1840


Ile Glu Leu Lys Tyr Leu Glu Asp Asp Leu Leu Leu Arg Leu Ser Ala 
                1845                1850                1855


Ala Glu Gly Ser Phe Leu Asp Asp Thr Lys Leu Val Glu Arg Leu Glu 
            1860                1865                1870


Ala Thr Lys Thr Thr Val Ala Glu Ile Glu His Lys Val Ile Glu Ala 
        1875                1880                1885


Lys Glu Asn Glu Arg Lys Ile Asn Glu Ala Arg Glu Cys Tyr Arg Pro 
    1890                1895                1900


Val Ala Ala Arg Ala Ser Leu Leu Tyr Phe Val Ile Asn Asp Leu Gln 
1905                1910                1915                1920


Lys Ile Asn Pro Leu Tyr Gln Phe Ser Leu Lys Ala Phe Asn Val Leu 
                1925                1930                1935


Phe His Arg Ala Ile Glu Gln Ala Asp Lys Val Glu Asp Met Gln Gly 
            1940                1945                1950


Arg Ile Ser Ile Leu Met Glu Ser Ile Thr His Ala Val Phe Leu Tyr 
        1955                1960                1965


Thr Ser Gln Ala Leu Phe Glu Lys Asp Lys Leu Thr Phe Leu Ser Gln 
    1970                1975                1980


Met Ala Phe Gln Ile Leu Leu Arg Lys Lys Glu Ile Asp Pro Leu Glu 
1985                1990                1995                2000


Leu Asp Phe Leu Leu Arg Phe Thr Val Glu His Thr His Leu Ser Pro 
                2005                2010                2015


Val Asp Phe Leu Thr Ser Gln Ser Trp Ser Ala Ile Lys Ala Ile Ala 
            2020                2025                2030


Val Met Glu Glu Phe Arg Gly Ile Asp Arg Asp Val Glu Gly Ser Ala 
        2035                2040                2045


Lys Gln Trp Arg Lys Trp Val Glu Ser Glu Cys Pro Glu Lys Glu Lys 
    2050                2055                2060


Leu Pro Gln Glu Trp Lys Lys Lys Ser Leu Ile Gln Lys Leu Ile Leu 
2065                2070                2075                2080


Leu Arg Ala Met Arg Pro Asp Arg Met Thr Tyr Ala Leu Arg Asn Phe 
                2085                2090                2095


Val Glu Glu Lys Leu Gly Ala Lys Tyr Val Glu Arg Thr Arg Leu Asp 
            2100                2105                2110


Leu Val Lys Ala Phe Glu Glu Ser Ser Pro Ala Thr Pro Ile Phe Phe 
        2115                2120                2125


Ile Leu Ser Pro Gly Val Asp Ala Leu Lys Asp Leu Glu Ile Leu Gly 
    2130                2135                2140


Lys Arg Leu Gly Phe Thr Ile Asp Ser Gly Lys Phe His Asn Val Ser 
2145                2150                2155                2160


Leu Gly Gln Gly Gln Glu Thr Val Ala Glu Val Ala Leu Glu Lys Ala 
                2165                2170                2175


Ser Lys Gly Gly His Trp Val Ile Leu Gln Asn Val His Leu Val Ala 
            2180                2185                2190


Lys Trp Leu Gly Thr Leu Glu Lys Leu Leu Glu Arg Phe Ser Gln Gly 
        2195                2200                2205


Ser His Arg Asp Tyr Arg Val Phe Met Ser Ala Glu Ser Ala Pro Thr 
    2210                2215                2220


Pro Asp Glu His Ile Ile Pro Gln Gly Leu Leu Glu Asn Ser Ile Lys 
2225                2230                2235                2240


Ile Thr Asn Glu Pro Pro Thr Gly Met Leu Ala Asn Leu His Ala Ala 
                2245                2250                2255


Leu Tyr Asn Phe Asp Gln Asp Thr Leu Glu Ile Cys Ser Lys Glu Gln 
            2260                2265                2270


Glu Phe Lys Ser Ile Leu Phe Ser Leu Cys Tyr Phe His Ala Cys Val 
        2275                2280                2285


Ala Gly Arg Leu Arg Phe Gly Pro Gln Gly Trp Ser Arg Ser Tyr Pro 
    2290                2295                2300


Phe Asn Pro Gly Asp Leu Thr Ile Cys Ala Ser Val Leu Tyr Asn Tyr 
2305                2310                2315                2320


Leu Glu Ala Asn Ser Lys Val Pro Trp Glu Asp Leu Arg Tyr Leu Phe 
                2325                2330                2335


Gly Glu Ile Met Tyr Gly Gly His Ile Thr Asp Asp Trp Asp Arg Lys 
            2340                2345                2350


Leu Cys Arg Val Tyr Leu Glu Glu Phe Met Asn Pro Ser Leu Thr Glu 
        2355                2360                2365


Asp Glu Leu Met Leu Ala Pro Gly Phe Ala Ala Pro Pro Tyr Leu Asp 
    2370                2375                2380


Tyr Ala Gly Tyr His Gln Tyr Ile Glu Glu Met Leu Pro Pro Glu Ser 
2385                2390                2395                2400


Pro Ala Leu Tyr Gly Leu His Pro Asn Ala Glu Ile Glu Phe Leu Thr 
                2405                2410                2415


Val Thr Ser Asn Thr Leu Phe Arg Thr Leu Leu Glu Met Gln Pro Arg 
            2420                2425                2430


Asn Ala Leu Ser Gly Asp Glu Leu Gly Gln Ser Thr Glu Glu Lys Val 
        2435                2440                2445


Lys Asn Val Leu Asp Asp Ile Leu Glu Lys Leu Pro Glu Glu Phe Asn 
    2450                2455                2460


Met Ala Glu Ile Met Gln Lys Asn Ser Asn Arg Ser Pro Tyr Val Leu 
2465                2470                2475                2480


Val Cys Phe Gln Glu Cys Glu Arg Met Asn Ile Leu Ile Arg Glu Ile 
                2485                2490                2495


Arg Ile Ser Leu Glu Gln Leu Asp Leu Ser Leu Lys Gly Glu Leu Ala 
            2500                2505                2510


Leu Ser Pro Ala Val Glu Ala Gln Gln Phe Ala Leu Ser Tyr Asp Thr 
        2515                2520                2525


Val Pro Asp Thr Trp Ser Lys Leu Ala Tyr Pro Ser Thr Tyr Gly Leu 
    2530                2535                2540


Ala Gln Trp Phe Asn Asp Leu Leu Leu Arg Cys Arg Glu Leu Asp Thr 
2545                2550                2555                2560


Trp Thr Gln Asp Leu Thr Leu Pro Ala Val Val Trp Leu Ser Gly Phe 
                2565                2570                2575


Phe Asn Pro Gln Ser Phe Leu Thr Ala Ile Met Gln Thr Met Ala Arg 
            2580                2585                2590


Lys Asn Glu Trp Pro Leu Asp Lys Thr Arg Leu Thr Ala Asp Val Thr 
        2595                2600                2605


Lys Lys Thr Lys Glu Asp Tyr Gly His Pro Pro Arg Glu Gly Ala Tyr 
    2610                2615                2620


Leu His Gly Leu Phe Met Glu Gly Ala Arg Trp Asp Thr Gln Ala Gly 
2625                2630                2635                2640


Thr Ile Val Glu Ala Arg Leu Lys Glu Leu Ala Cys Pro Met Pro Val 
                2645                2650                2655


Ile Phe Ala Lys Ala Thr Pro Val Asp Arg Gln Glu Thr Lys Gln Thr 
            2660                2665                2670


Tyr Glu Cys Pro Val Tyr Arg Thr Lys Leu Arg Gly Pro Ser Tyr Ile 
        2675                2680                2685


Trp Thr Phe Arg Leu Lys Ser Glu Glu Lys Thr Ala Lys Trp Val Leu 
    2690                2695                2700


Ala Gly Val Ala Leu Leu Leu Glu Ala 
2705                2710


<210>  3598
<211>  709
<212>  DNA
<213>  Homo sapiens

<400>  3598
agctttctca ggactttcca gattttagca ctgaaagtat cacatccctg aaatccactt     60

gctagaaacc cctcagtccg gagcaaatca gggcatttgg tcctcttatg cagaggcgtg    120

gatggtgcta aggaatgtta gagggtaggg aggggcagag ggtggcagct tccaagaagc    180

agattctgga tattcttagc aaaagccgga aagaaaatgg ctttcctgca acccatatgg    240

ctggctcaac tcttcactta caggagacat gagtgagttt gggtcaagtt tttaataaat    300

gaagccacaa ctttggcaga tttgttagca ctgcggttac acagagtgga agatgatgtc    360

cgaaggattg tggacaaggc ggtgaaagag ctggggactg agaaggttat tactgaaatc    420

agtcagacct gggcaaccat gaagttttct tacgaagttc actatcgaac aggcattcca    480

ttactaaagt ctgatgaaca actttttgaa actctagagc acaaccaagt tcagttgcag    540

actcttcttc aaagcaagta tgtagaatat ttcattgagc aagtgttaag ctggcaaaat    600

aaattaaaca tagcagactt ggtcatcttc acttggatgg aagtccagcg aacttggtct    660

cacctggaaa gcatttttgt ctgttcagaa gatattcgaa tccagcttg                709


<210>  3599
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  3599

Met Lys Phe Ser Tyr Glu Val His Tyr Arg Thr Gly Ile Pro Leu Leu 
1               5                   10                  15


Lys Ser Asp Glu Gln Leu Phe Glu Thr Leu Glu His Asn Gln Val Gln 
            20                  25                  30


Leu Gln Thr Leu Leu Gln Ser Lys Tyr Val Glu Tyr Phe Ile Glu Gln 
        35                  40                  45


Val Leu Ser Trp Gln Asn Lys Leu Asn Ile Ala Asp Leu Val Ile Phe 
    50                  55                  60


Thr Trp Met Glu Val Gln Arg Thr Trp Ser His Leu Glu Ser Ile Phe 
65                  70                  75                  80


Val Cys Ser Glu Asp Ile Arg Ile Gln 
                85


<210>  3600
<211>  2035
<212>  DNA
<213>  Homo sapiens

<400>  3600
agcagtagga tctcggtttc cagcccagtg caatttctgc tctatcccgc tgacctcatt     60

gttgaggtat gtccttatag cagtgtgaga accgactaat acagttcctt aggaagcccc    120

tgctgggtat ggatggggag tgaagcaagg tgggcccaga agctgccgct ggctgagaga    180

ccatgaagaa agtgtataga atctccacca tcaccagagg aagagagctt ggcaggaaag    240

ttacttccat gaatggatga gttgaagtga acagcgtctt gggcaaaact gaagggtagt    300

tagtcgggtt tgtctctggt gggctttcag ctccactccc tgcatcccat tcccacatcg    360

tgatggtccc ctcataggcc cagggctacc accttggagc ataggtgggg atcctccagc    420

cagggtcctt ccttcacagg gagtcagagc cctctgctcc ggaattgccc tgccccaggt    480

cggccatcta tcaaaagccc cactatcccc taaagaccca ccctcaagca gcagatgtgc    540

agcaagggag ccgcaaatgt cattcctgtg accccgaagc agtctagtgt gttacctctc    600

tcagggctgc tatgggctga attgcttttc cccaaaattt ctatgctgct tccctaaccc    660

ccagcgcctc agaatctaac tctggatagg acctgtgaat aagtgattaa gttaaaatgg    720

ggtcctgtgg atgggcccta acccaatctg actggtgtcc ttttaagaag aggaagagac    780

accagagatg tgcacactca gagacaagac acatgaggac acagagacaa ggcggctacc    840

tgcaagccag ggagaggggc ctcggggaag ccaaccctgc ctacgccttg atcttggact    900

tccagcctcc agaactccag aatctgagtg aaatgggtat aaatcatgag ctaggataca    960

gttcaattat tcctatgatg aaaagagctt tctccgcatg tgggactctc ggcctcatta   1020

tgagtggcat ctttgacaat ccagggccca ttaaaaacac cttgaagaaa gcattcacca   1080

tgctgtggag cttcacagtc tataccaggc tggaatcctt gagggtggca ttatcaaatg   1140

aggaaatggt tcctttcatt tttcatctga agactcagac agcaaacatg ttatctggcc   1200

ctataagcac cccgatgctt ctgtgaaacc caagcaagtt ctgcatcacc acgacagccg   1260

cggatgtcaa atcatcaaaa cagcagcaga ggaaggggtt tattcctcct ccaaatcttc   1320

agctggtttt atagggttac cagtttaaag tttctttgtt ttcagagcat cagacctccc   1380

atttgtagct gatagccatt tttcaaaggt ttctggctca cccaggaatt cattagggtg   1440

gacgagaaaa gaacagtgga tagaatagac cagcagggca atctaagccc cattccctgt   1500

ctctttacat tggttcttgg tccccgtgac tcatccaaac tcccttatat tcctatctgg   1560

aatgcgaaag ctggaaatac aagtgctctg taatcacagg cagtggtttt cttggagtct   1620

ggtgtgattt ctgtagcttg cagcaatatg tgggacacac ttgcactgaa gaatttaatg   1680

acttgtttta ctgctgtctg ccatcaatat ttatctatat taactgaaga aaggcattac   1740

tcgaaatggc atttcacacc tctgagcatt atacagtaat tctaaagtca tacgttgtac   1800

caaattctct gggcaaacac agagatacag tatgaatgga aagaatccaa gttgaagttt   1860

ttaaaacttg aattgtctgc agtaatctgg aaaaccaaag tcaaaatgac tcgaattgct   1920

atggctggga atgactggat taaaagcaat ggaaacaatc gtttctcggc ttggtttttc   1980

ttgaattagc aggagcacat ttcaagtata tttaatagaa aagaaaaact gggcc        2035


<210>  3601
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  3601

Met Gly Ser Cys Gly Trp Ala Leu Thr Gln Ser Asp Trp Cys Pro Phe 
1               5                   10                  15


Lys Lys Arg Lys Arg His Gln Arg Cys Ala His Ser Glu Thr Arg His 
            20                  25                  30


Met Arg Thr Gln Arg Gln Gly Gly Tyr Leu Gln Ala Arg Glu Arg Gly 
        35                  40                  45


Leu Gly Glu Ala Asn Pro Ala Tyr Ala Leu Ile Leu Asp Phe Gln Pro 
    50                  55                  60


Pro Glu Leu Gln Asn Leu Ser Glu Met Gly Ile Asn His Glu Leu Gly 
65                  70                  75                  80


Tyr Ser Ser Ile Ile Pro Met Met Lys Arg Ala Phe Ser Ala Cys Gly 
                85                  90                  95


Thr Leu Gly Leu Ile Met Ser Gly Ile Phe Asp Asn Pro Gly Pro Ile 
            100                 105                 110


Lys Asn Thr Leu Lys Lys Ala Phe Thr Met Leu Trp Ser Phe Thr Val 
        115                 120                 125


Tyr Thr Arg Leu Glu Ser Leu Arg Val Ala Leu Ser Asn Glu Glu Met 
    130                 135                 140


Val Pro Phe Ile Phe His Leu Lys Thr Gln Thr Ala Asn Met Leu Ser 
145                 150                 155                 160


Gly Pro Ile Ser Thr Pro Met Leu Leu 
                165


<210>  3602
<211>  530
<212>  DNA
<213>  Homo sapiens

<400>  3602
tccttccctc tgcacttctc gctgctgcca cgtcgcaaag gaagtgtttt cttctccttc     60

cgccatgatt ataaatttcc tgaggcctcc ccagccctgc ggaactaaga ggaagagaca    120

ccagagatgt gcacactcag agacaagaca catgaggaca cagagacaag gcggctacct    180

gcaagccagg gagaggggcc tcggggaagc caaccctgcc tacgccttga tcttggactt    240

ccagcctcca gaactccaga atctgagtga aatgggtata aatcatgagc taggatacag    300

ttcaattatt cctatgatga aaagattttg gtgtttgtgg gaattcttgg aaccaattcc    360

ctgtgggtac cgaggagcac ctgtacatgt cacatgttgc gtattcattc atcggtgggt    420

ggacactgca gcagtctcca tcccttgcct actgtgaata acgctggtat ggacatgtgc    480

tatcctgctt ttatatttac aaactcttca ctaaattatc agattctcac               530


<210>  3603
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  3603

Met Ile Ile Asn Phe Leu Arg Pro Pro Gln Pro Cys Gly Thr Lys Arg 
1               5                   10                  15


Lys Arg His Gln Arg Cys Ala His Ser Glu Thr Arg His Met Arg Thr 
            20                  25                  30


Gln Arg Gln Gly Gly Tyr Leu Gln Ala Arg Glu Arg Gly Leu Gly Glu 
        35                  40                  45


Ala Asn Pro Ala Tyr Ala Leu Ile Leu Asp Phe Gln Pro Pro Glu Leu 
    50                  55                  60


Gln Asn Leu Ser Glu Met Gly Ile Asn His Glu Leu Gly Tyr Ser Ser 
65                  70                  75                  80


Ile Ile Pro Met Met Lys Arg Phe Trp Cys Leu Trp Glu Phe Leu Glu 
                85                  90                  95


Pro Ile Pro Cys Gly Tyr Arg Gly Ala Pro Val His Val Thr Cys Cys 
            100                 105                 110


Val Phe Ile His Arg Trp Val Asp Thr Ala Ala Val Ser Ile Pro Cys 
        115                 120                 125


Leu Leu 
    130


<210>  3604
<211>  3354
<212>  DNA
<213>  Homo sapiens

<400>  3604
ggtagtttat ggtcaataat aaaggaataa taaatgcctt agggaaacta ttttaaagga     60

acctatttgt gaattatttt ttaagcagtt ttttggtatt attagtgttt ccgtattctc    120

taatttatct gttaaagtgt gtatattaga ttttcttaag aaggggcaca catctatcaa    180

cattctaaat cattttaggt catataagtt taagaaataa gtagtttatt gtaaaaaaaa    240

ttattttatc cttgctagat gataagcttc ttgaaggcaa atataatagc ttaaggatcc    300

tggctttaac cttctatagc ctcttacaca tgaaaggtat ccccaggctc tgtggagaga    360

gagagtgtcc ccgagagaag gcttcctgag gtagtttcat tttctaggtt ttcatcatga    420

gtgattgttt ctgtgttctg tgcccaataa taaacaggct ttgtgttata ccttaattta    480

aatcgttgcc taacagcatt ttaaagtgtc cagaaacaaa aagatgaaaa tgtttacatt    540

tgcagctcaa gctcttttaa ctttataaat agaaataaca tttctaagaa gttgcataca    600

aacgacattg tacttacacc agtctaaagg ttaatattgc atattgtttt caattaggaa    660

tacaatagat atggctggtg ggtaggagaa atgaagggag ccattggctt ggtgcctaaa    720

gcctacataa tggagatgta tgatatttga gagtcctgga aaaggaaaat tcttctgctt    780

gtctgcaaat gctttggatt tagaagcgtc atgaaagcac gagtgacagc tcctaacctc    840

tccttgtttt attaaacatt acttatcttt gactgttatt ttatgcagtc gctcattaaa    900

atattcctct gatgtgaaat taaatgaagg atattaatgt aaattagatg caaccagtta    960

agttatacct gttgctattt tgcaaagaaa taattatagt ttttatttac ccatttgatt   1020

tgtgtgaaga attcatcact attttatacg taacatatag tctactatag catagtatgc   1080

tactattgct acttctggtg tgatttgtaa tgtttcttaa tcattggaca tcaattattt   1140

ttagagagta atgtataatt tcatagcatt ttaaatttag tgtatcatgc gagttttttt   1200

tggtagatgc tgaagaatgt ggttgctaaa caaagaatgc taaagaatgt tcaaacttta   1260

tagataactt tattgttatt atttattttc acacatttaa ttcctattaa gtacagccgc   1320

aagaaagaaa aaatgatgaa gttgcaaatg gcagtgtgct gtcacctgca acagaagtgc   1380

gtaccagaag tatgactcat gcaaagcatt ttaccgtaca aatatcctgg tgcgatgatg   1440

ggcctggcaa cattttctac tgtacttttg tttaaattta atgaaacaaa aaattcctaa   1500

gaaataccac cctaccacta acaaaatggt ataaagaatc tcccagccag gccaacatgg   1560

tgaaaccctg tctctactaa aaattagcca agtgtggtaa tgttcacctg cagtcccagc   1620

tacttgggag gccaaggcac gagaattgct tgaacaaggt aggcagaggt tgcagtgagc   1680

caagatcgcg ccactgcact ccagcctggg cgacagagtg agactccatc tcagaaaaaa   1740

aaaaaaaaaa aaacagaatc tcagtgtatt ctcaaagtaa aaaggcataa ccaagcactc   1800

tcttatcttg ccttattgct atactattta catcccactg cagaacagca gatttgaggc   1860

ttttctatat acttctcaga gcactgaaaa gaaaggaagg gtttgcagag gagagtgtag   1920

aaatcccagt ggtagcatgt accaacaggt gagtagaaag gtagtgttag cctgacattt   1980

gagttatact ctgtgctgcc tgagcaagat ttgtagaatc atataattac cttttcatgt   2040

atatttgaaa tcagaggtgt ttaaaatacc tatgagatac caatgtagcc ttaacatatg   2100

tcaaaatgca ttgctggtta gataattatt tggactacac ataaactcct aatattgaat   2160

cattacctat caggtattat ctttatggaa cttttcaata tctttgcttt ataaagattc   2220

taaacatgta tctgagctgg taatatttta aaatctccat tatttgtgta aaactgttta   2280

taagcagtgt ttgagagggt ctgctttacc attaccccct caatatcatg atcatccaat   2340

ctcaaatgtg aaaaaaaaaa agaaatttga ttttagggat tgtgagtaaa caagtttata   2400

tagagagaca ttgtgaagtt aaagttttca gaagttacat ttgtgcagtt cttacctttt   2460

cctcatatag tgccattgaa atagactgaa attatcttgg caaaagttag acaaccaaag   2520

acgactttag tggactggtt ttcaaaactt gagcagctga aaagcaaaag ccgttgtttc   2580

ccatgacaat gtagcctttg tggatttggg tttgtgcttt gggttgaaaa gaagttttta   2640

gtcctaggcc agtagatggc agcagctttt cattgcagac aaaacctctt gaaacccttc   2700

ccccatggca caaactcgcc catgatggaa agcatctaga tttctgcctc cttttacagt   2760

taatccagga gagggagtcc tttgccaact gatgaccaac agttccaagc cagatagtct   2820

cgtgaacagt gacaatacag aaataaggtg ttatttctgt tcagatctcc accggccttt   2880

gttcttttaa aacttgaata taggtgggag acataagaaa ggaaagaaaa gacttaaaac   2940

tggagtgaca ggacaaataa tcattacttt caattcatga ctgctttata ttcatttgat   3000

gaaatcattt gtatacaaac cagggagagt tttctttaca cccttgacaa tatatcacat   3060

actcttcaag atcataataa tatcattaat ataaatttaa acaacatggc ttgttagaaa   3120

atatgctaat tgctatggtc tcattatgtt tgcttagctt ttatttgttt ttctgtgaac   3180

agttagagag ctaatttttt tcaaaggtga ttgtaagtca tattttatat agcattttgc   3240

ttgattattt gctctgtact gaatttgtac tctattgcca ttagatctta caataatgtt   3300

ccactctgca aatttttaag gttcaaataa agtttaattg tttgcaaact gtta         3354


<210>  3605
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  3605

Met Thr Ala Leu Tyr Ser Phe Asp Glu Ile Ile Cys Ile Gln Thr Arg 
1               5                   10                  15


Glu Ser Phe Leu Tyr Thr Leu Asp Asn Ile Ser His Thr Leu Gln Asp 
            20                  25                  30


His Asn Asn Ile Ile Asn Ile Asn Leu Asn Asn Met Ala Cys 
        35                  40                  45


<210>  3606
<211>  4021
<212>  DNA
<213>  Homo sapiens

<400>  3606
agcggtgggc gtggcttgcc cacaggctct ttcttctggg gccgggaaaa ccgaggaata     60

cacatgcgca gttggacccc tcaggccctt cgtgtccctt cccacccatc tccccgcccc    120

ggccctctgg gcggggctgg gccgacagtc cagctgcagc tcgctggaga ttcagtgact    180

tccttgttgt gagccccggc ccggcagtgt cccgactcgt agccccgctg ttcttaatcc    240

gggccgctag cctgagtcta ggtcgcagcc gcagccccac cccgtcggtc accttttcag    300

cgcaggtcct ttccccgcac gccctgcgct ccctaacatg cccaacccca gcagcacctc    360

ctctccctac cccctccctg aggaaattag gaacctgttg gcagatgttg aaacatttgt    420

agcagatata ctgaaaggag aaaatttatc caagaaagca aaggaaaaga gagaatccct    480

tattaagaag ataaaagatg taaagtctat ctatcttcag gaatttcaag acaaaggtga    540

tgcagaagat ggggaagaat atgatgaccc ttttgctggg cctccagaca ctatttcatt    600

agcctcagaa cgatatgata aagacgatga agccccctct gatggagccc agtttcctcc    660

aattgcagca caagaccttc cttttgttct aaaggctggc taccttgaaa aacgcagaaa    720

agatcacagc tttctgggat ttgaatggca gaaacggtgg tgtgctctca gtaaaacggt    780

attctattat tatggaagtg ataaagacaa acaacagaaa ggtgaatttg caatagatgg    840

ctacagtgtc agaatgaata acactctaag aaaggatgga aagaaagatt gctgttttga    900

aatctctgct cctgataaac gtatatatca gtttacagca gcttctccca aagatgctga    960

agaatgggta cagcagctga aatttgtatt gcaagatatg gaatctgata ttattcctga   1020

ggattatgat gagagaggag aattatatga tgatgttgat catcctctac caataagcaa   1080

tccactaaca agcagtcaac caatagatga tgaaatttat gaagaacttc cagaagaaga   1140

agaggacagt gctccagtga aagtggaaga acaaaggaag atgagtcagg atagtgtcca   1200

tcacacctca ggggataaga gcactgatta tgctaatttt taccagggat tgtgggattg   1260

tactggagct ttttctgatg agttgtcatt taagcgtggt gatgtgattt acattcttag   1320

caaggaatac aatagatatg gctggtgggt aggagaaatg aagggagcca ttggcttggt   1380

gcctaaagcc tacataatgg agatgtatga tatttgagag tcctggaaaa ggaaaattct   1440

tctgcttgtc tgcaaatgct ttggatttag aagcgtcatg aaagcacgag tgacagctcc   1500

taacctctcc ttgttttatt aaacattact tatctttgac tgttatttta tgcagtcgct   1560

cattaaaata ttcctctgat gtgaaattaa atgaaggata ttaatgtaaa ttagatgcaa   1620

ccagttaagt tatacctgtt gctattttgc aaagaaataa ttatagtttt tatttaccca   1680

tttgatttgt gtgaagaatt catcactatt ttatacgtaa catatagtct actatagcat   1740

agtatgctac tattgctact tctggtgtga tttgtaatgt ttcttaatca ttggacatca   1800

attattttta gagagtaatg tataatttca tagcatttta aatttagtgt atcatgcgag   1860

ttttttttgg tagatgctga agaatgtggt tgctaaacaa agaatgctaa agaatgttca   1920

aactttatag ataactttat tgttattatt tattttcaca catttaattc ctattaagta   1980

cagccgcaag aaagaaaaaa tgatgaagtt gcaaatggca gtgtgctgtc acctgcaaca   2040

gaagtgcgta ccagaagtat gactcatgca aagcatttta ccgtacaaat atcctggtgc   2100

gatgatgggc ctggcaacat tttctactgt acttttgttt aaatttaatg aaacaaaaaa   2160

ttcctaagaa ataccaccct accactaaca aaatggtata aagaatctcc cagccaggcc   2220

aacatggtga aaccctgtct ctactaaaaa ttagccaagt gtggtaatgt tcacctgcag   2280

tcccagctac ttgggaggcc aaggcacgag aattgcttga acaaggtagg cagaggttgc   2340

agtgagccaa gatcgcgcca ctgcactcca gcctgggcga cagagtgaga ctccatctca   2400

gaaaaaaaaa aaaaaaaaaa cagaatctca gtgtattctc aaagtaaaaa ggcataacca   2460

agcactctct tatcttgcct tattgctata ctatttacat cccactgcag aacagcagat   2520

ttgaggcttt tctatatact tctcagagca ctgaaaagaa aggaagggtt tgcagaggag   2580

agtgtagaaa tcccagtggt agcatgtacc aacaggtgag tagaaaggta gtgttagcct   2640

gacatttgag ttatactctg tgctgcctga gcaagatttg tagaatcata taattacctt   2700

ttcatgtata tttgaaatca gaggtgttta aaatacctat gagataccaa tgtagcctta   2760

acatatgtca aaatgcattg ctggttagat aattatttgg actacacata aactcctaat   2820

attgaatcat tacctatcag gtattatctt tatggaactt ttcaatatct ttgctttata   2880

aagattctaa acatgtatct gagctggtaa tattttaaaa tctccattat ttgtgtaaaa   2940

ctgtttataa gcagtgtttg agagggtctg ctttaccatt accccctcaa tatcatgatc   3000

atccaatctc aaatgtgaaa aaaaaaaaga aatttgattt tagggattgt gagtaaacaa   3060

gtttatatag agagacattg tgaagttaaa gttttcagaa gttacatttg tgcagttctt   3120

accttttcct catatagtgc cattgaaata gactgaaatt atcttggcaa aagttagaca   3180

accaaagacg actttagtgg actggttttc aaaacttgag cagctgaaaa gcaaaagccg   3240

ttgtttccca tgacaatgta gcctttgtgg atttgggttt gtgctttggg ttgaaaagaa   3300

gtttttagtc ctaggccagt agatggcagc agcttttcat tgcagacaaa acctcttgaa   3360

acccttcccc catggcacaa actcgcccat gatggaaagc atctagattt ctgcctcctt   3420

ttacagttaa tccaggagag ggagtccttt gccaactgat gaccaacagt tccaagccag   3480

atagtctcgt gaacagtgac aatacagaaa taaggtgtta tttctgttca gatctccacc   3540

ggcctttgtt cttttaaaac ttgaatatag gtgggagaca taagaaagga aagaaaagac   3600

ttaaaactgg agtgacagga caaataatca ttactttcaa ttcatgactg ctttatattc   3660

atttgatgaa atcatttgta tacaaaccag ggagagtttt ctttacaccc ttgacaatat   3720

atcacatact cttcaagatc ataataatat cattaatata aatttaaaca acatggcttg   3780

ttagaaaata tgctaattgc tatggtctca ttatgtttgc ttagctttta tttgtttttc   3840

tgtgaacagt tagagagcta atttttttca aaggtgattg taagtcatat tttatatagc   3900

attttgcttg attatttgct ctgtactgaa tttgtactct attgccatta gatcttacaa   3960

taatgttcca ctctgcaaat ttttaaggtt caaataaagt ttaattgttt gcaaactgtt   4020

a                                                                   4021


<210>  3607
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  3607

Met Pro Asn Pro Ser Ser Thr Ser Ser Pro Tyr Pro Leu Pro Glu Glu 
1               5                   10                  15


Ile Arg Asn Leu Leu Ala Asp Val Glu Thr Phe Val Ala Asp Ile Leu 
            20                  25                  30


Lys Gly Glu Asn Leu Ser Lys Lys Ala Lys Glu Lys Arg Glu Ser Leu 
        35                  40                  45


Ile Lys Lys Ile Lys Asp Val Lys Ser Ile Tyr Leu Gln Glu Phe Gln 
    50                  55                  60


Asp Lys Gly Asp Ala Glu Asp Gly Glu Glu Tyr Asp Asp Pro Phe Ala 
65                  70                  75                  80


Gly Pro Pro Asp Thr Ile Ser Leu Ala Ser Glu Arg Tyr Asp Lys Asp 
                85                  90                  95


Asp Glu Ala Pro Ser Asp Gly Ala Gln Phe Pro Pro Ile Ala Ala Gln 
            100                 105                 110


Asp Leu Pro Phe Val Leu Lys Ala Gly Tyr Leu Glu Lys Arg Arg Lys 
        115                 120                 125


Asp His Ser Phe Leu Gly Phe Glu Trp Gln Lys Arg Trp Cys Ala Leu 
    130                 135                 140


Ser Lys Thr Val Phe Tyr Tyr Tyr Gly Ser Asp Lys Asp Lys Gln Gln 
145                 150                 155                 160


Lys Gly Glu Phe Ala Ile Asp Gly Tyr Ser Val Arg Met Asn Asn Thr 
                165                 170                 175


Leu Arg Lys Asp Gly Lys Lys Asp Cys Cys Phe Glu Ile Ser Ala Pro 
            180                 185                 190


Asp Lys Arg Ile Tyr Gln Phe Thr Ala Ala Ser Pro Lys Asp Ala Glu 
        195                 200                 205


Glu Trp Val Gln Gln Leu Lys Phe Val Leu Gln Asp Met Glu Ser Asp 
    210                 215                 220


Ile Ile Pro Glu Asp Tyr Asp Glu Arg Gly Glu Leu Tyr Asp Asp Val 
225                 230                 235                 240


Asp His Pro Leu Pro Ile Ser Asn Pro Leu Thr Ser Ser Gln Pro Ile 
                245                 250                 255


Asp Asp Glu Ile Tyr Glu Glu Leu Pro Glu Glu Glu Glu Asp Ser Ala 
            260                 265                 270


Pro Val Lys Val Glu Glu Gln Arg Lys Met Ser Gln Asp Ser Val His 
        275                 280                 285


His Thr Ser Gly Asp Lys Ser Thr Asp Tyr Ala Asn Phe Tyr Gln Gly 
    290                 295                 300


Leu Trp Asp Cys Thr Gly Ala Phe Ser Asp Glu Leu Ser Phe Lys Arg 
305                 310                 315                 320


Gly Asp Val Ile Tyr Ile Leu Ser Lys Glu Tyr Asn Arg Tyr Gly Trp 
                325                 330                 335


Trp Val Gly Glu Met Lys Gly Ala Ile Gly Leu Val Pro Lys Ala Tyr 
            340                 345                 350


Ile Met Glu Met Tyr Asp Ile 
        355


<210>  3608
<211>  8189
<212>  DNA
<213>  Homo sapiens

<400>  3608
gatctgatga atccaaggag tggagcaaga ggcagatttt ggacacggtt atgagaatga     60

cagaaactgc ctaaagcatt tatgctctgg cattcgtccc tgtttctgga ggtccagtaa    120

gcgcttccca acagaggacc atctgatgat tcataggcac aaacatgaaa tgactttgaa    180

gtttccttca ataaaaacag acaatatgtt atcagatcaa actccgaccc caacgagatt    240

cctgaagaac tgcgaggagg tgggcctctt cagcgagctg gactgctccc tggagcacga    300

gttcaggaag gctcaggaag aggagagcag caagcggaat atctcgatgc ataatgcagt    360

tggtggggcc atgacggggc ccggaactca ccagcttagc agcgctcggc tgcccaacca    420

tgacaccaac gttgtgattc agcaagccat gccgtcgcct cagtccagct ctgtcatcac    480

tcaggcacct tccaccaacc gccagatcgg gcctgtccca ggctctctat cttctctgct    540

acatctccac aacagacaga gacagcccat gccagcctcc atgcctggga ccctgcccaa    600

ccctacaatg ccaggatctt ccgccgtctt gatgccaatg gagcgacaaa tgtcagtgaa    660

ctccagcatc atggggatgc aaggtccaaa tctcagcaac ccctgtgctt ctccccaggt    720

ccagccaatg cattcagaag ccaaaatgag gttgaaggct gcattgactc accaccctgc    780

tgccatgtca aatgggaaca tgaacaccat gggacacatg atggagatga tgggctcccg    840

gcaggaccag acgccacacc atcacatgca ctcgcacccg catcagcacc agacactgcc    900

accccatcac ccttacccac accagcacca gcacccagca caccatcctc accctcaacc    960

ccatcaccag cagaaccatc cacatcacca ctcccattcc caccttcatg cacacccagc   1020

acatcaccag acctcgccac atccgcccct gcacaccggc aaccaagcac aggtttcacc   1080

agcaacacaa cagatgcagc caacccagac aatacagcca ccccagccca caggggggcg   1140

ccggcgaagg gtggtagacg aggatccgga cgagaggcgg cggaaatttc tggaacggaa   1200

ccgggcagct gccacccgct gcagacagaa gaggaaggtc tgggtgatgt cattggaaaa   1260

gaaagcagaa gaactcaccc agacaaacat gcagcttcag aatgaagtgt ctatgttgaa   1320

aaatgaggtg gcccagctga aacagttgtt gttaacacat aaagactgcc caataacagc   1380

catgcagaaa gaatcacaag gatatctaag tccagagagt agccctcctg ctagtcctgt   1440

cccagcttgc tcccagcaac aagtcatcca gcataatacc atcactactt cctcatcggt   1500

cagcgaggtg gtaggaagct ccaccctcag ccagctcacc actcacagaa cagacctgaa   1560

tccgattctt taaaatgcac catcagacct ggcctccaag aagagctgta gcgtaccatg   1620

cgtcctttct tttaagggca tttttagaat taactcagac ctggaagact cctcagttct   1680

tcaaagactg gctttcattt ttatagttat tatggaaatg ttgtctttta tacttagtta   1740

tataagaaaa aagggagtta tgcaattaat atctatcagc ttgggaaacg ctttggtgct   1800

tttctccagt tttctggtac cagttacttg tttataaact gaaccttttc tgtatatagc   1860

catggtttca ttcttatcag tccaaccctt tgcctgaaac attgaatctt gttaaaccac   1920

agcttttagc taaaatgagg tatacctaga tgtcaagtaa gacagatcca aggtaactgg   1980

gtaggaaatc ttttgacatc ttaactcatg ttgagtttgt gctgtggtgt caccagaatt   2040

ccagataaac acacagcctt tcccatacct ttttttttct tactataaaa tattataaga   2100

tccattgatg tccaaataat accaccaagc atctcttcac ctctcctcct cttggtccac   2160

ttgctaatgc ccagttttct tctccatttc cactttttct taggctccct atttactatt   2220

cattttgact tccttctgtt ttattttttt ccctttagca ttgcatgtga ataagaaaat   2280

aatgtttaaa gaaaaaaaaa aaaaagcaaa cctccaaaac gtggacctaa ccattgcttc   2340

acttacactt cacccacagc tggagttcat tcaactcttg cttttcacaa aatagtaacc   2400

aggagatgtt taatgtgcct gatttaatgt ttttaataat cacagcaaat gaaaggtggt   2460

ttagttataa gtgaagcatg gttgaatacc agctggggag acactaggga agggagcttt   2520

gtaagccttg attgcgaaag tccaaatttt gatgtggggc tataacatga cacccttgga   2580

ttgcgactgg ttttatacgg cctgcctata acgttgaaaa tccatgtact acataataat   2640

tcagaagggc tctattcact acacagatta cattgttcaa tcatcagctg ctaatagcct   2700

aagatttatt tttttttttt tcttaagcct atggaaccgg ctttgctgtt ctggggggtg   2760

aaaatagact aactactgga gaaacaaaga gagaaagaaa acccagtgtt tccatagggg   2820

cacttttagc cttcccacaa cagttaagca ctctttgact gctgaaggaa ccccatggat   2880

gaggtgcagg ctacttcact cttttttttt cttttttgag acagagtctc acctattgcc   2940

cagactgaag tgcagtggtg cgatcatgga tcactgcagc agcatcctcc gagttcaagc   3000

tatccttcca cctccgcctc ctgagtagct gggaccacag gttcacataa ccatgcctgg   3060

ctaatttatt tttactttta ttttaaaata aaagatgagg tctgtcttat gttgcccagg   3120

ctggtctcaa actatcctac ttcttcctcc caaagtgttg ggattatagg tgtgagccac   3180

tgcacccagc ctacttcact cttctgaatt attctgattt attttcaaca acttttgtga   3240

acttgcccgt gatacaaagc agatagtccc tgaaccacag tcgtgcctcc ttgaaacaag   3300

ccattctact gtgctaatgt tttaatatca catctcacaa ataacagggg tgaatgtttc   3360

tctctagcaa tctaggcagg tgctggtgtt tcatctccat ttgaatgctt gacctcttaa   3420

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgttcatggg ttttaaaaga acagtatttt   3480

acaaaaggtg tagcttttat aagagtgcag aaaagggaag gatgtgtttt tttctctcac   3540

tatagtataa gaatctattt tggagaaaaa aagaaaatat gagggtctcg aagcatgatt   3600

tttatataac tagtttcagt tttatctaat aacttacttt ttaaatcaat atttatcaac   3660

aatctttcct tgtatgcagt gctttcaaaa gatggttttg agtgtccagt gaaacttatg   3720

acttggatat atggttgaag aatcaaaaca aaagcaaaaa aaaaaagcaa aaaaagaaaa   3780

gagaaaaaaa gaaaaaatgc aaatggaata attttctatt atattttaga caaacatatc   3840

attttcgagt attttaaata ctgaattcat agttgttgtt ttttaaattc caacagtaac   3900

agctgaatgg tttaatctga ctggcttcct aagaaatgtt taagactcag ctttaaaaag   3960

aagttaacat tcatatctct gttttgaaat caaaaatcat atttcaaaat tctttcctag   4020

gaccatctat gtgtctcccc tcccctccac aaaaaggaga aagagtgcat taaaatgttt   4080

agttgggttt tttaattttt aatttttatg ttatgttttg ctttgtttta agtaaacaaa   4140

aatttttctt tctttactgc atgcatagca cttaataaaa tggattttta aaaaatccac   4200

tagtaatatc agaatgtcca gggagtgact gtcactacaa tgatggttta gtttacttct   4260

gttccacctt ttgattgaaa tatttagttg ttaggctgaa agcctcggca gttaagaact   4320

tgcctgagtt ttcttcgttc agcaacttga cagtttgact gatgtgcatt atatatagct   4380

caattatgtc tgttttttat gctaagtagg aaaaccaacc acacacatta gcaaaccggc   4440

ctcaacatat aattagaata aactgtcttc ttgttctact cagggccttt aggtgtgttc   4500

attcacggta tggaaataca gtaaatgaaa gattccaact agttgtcagt gcttcttgaa   4560

attccaaaca gaaagataca ttggtcaaat ccaacacttg gcttatcaat attaagtctt   4620

ttacctaaag gcccagccgt caccagacaa cagaataatc aatctgcctg aaaatccctc   4680

ctccttgtcc tacacttttt gcctgtttgg gagaatatct ttgtactcca ttctcctccc   4740

tcagccagtt actgggtcac ccatccatgt gttcatgaat caatcatcac ggcctgcaga   4800

gcacctgtcc taaggaggga aaatcctgtc acactgcctc tccccattcg tgtgtggttt   4860

tcttgatcgg tgagatctgt ctctgaagtc actgccagcc tccctgggaa cgtctatagt   4920

gcctcccctg ccttatgtga tgggagttaa caactcagat aagtacacct gagagcattt   4980

ctatcaggta aactgtcact taaatggagg tgtccacatc ttaattgttt ctccttgaca   5040

catttctcaa tccacgaagc caggagaggt agagtgaaaa tcccagccat ggatgaatgt   5100

actaatttga aagccaagtg ttaagtcgga tgttttcccg ttacactact actcagccct   5160

ctcctgcggc cacatcaacg gatgcaagtc acagtcttaa cacagcctgt gggagacaag   5220

cagtttgtgt gctcacagta tatattatag taattagggt gacttagagc aaatactctt   5280

cagatcctat gtagtcagtg aaacaaaatg gagagcgtat tctgatagaa ggacgtcgac   5340

ggtgaatgtt ctggtggttg ttgcctgtta agtaaacttt agtgtgtaag ttgagtttgt   5400

cattaaaatc ataaaccagc tgcggtaaca gacaagcctt tggctgggga gttttaagcc   5460

tcggtaactg ctataaaact agccatccag ttaggataga atgtgtttct ttctggttaa   5520

aaaaaggaaa aaccatctaa gaaaatatat atgtatgtat gtgtgtatac agtggaattc   5580

aaaggaccaa agcaaaattt gaacaggaat ctattaattt agaattttat aagatattta   5640

ttaataaatg ttatttttaa acattccatt tgaacagtat tctgtaggat ctacttgttt   5700

ttaaagtgtt agtccataat aaactactat agttatgtgt attttcattt ttcagggttt   5760

caaatggcta ttctccatca tttggtggaa atgtttgctt agatctctgt gcatagacat   5820

ttcaaggatt tttattgctc tgtgagttat tttttaatca acattctgaa cagttttttt   5880

taaacattta tttctgtgtg ttcattttta aagtaagctc tttcatttag gaagcagagt   5940

tcagctaaag ggaatcagta actctaactg gaacagcttt cttgtagaag tgtaaaaaca   6000

gcttcatctc tgcctctctc caccccaccc caatttccta gaaagccttg cactattcag   6060

ctcccttagt gctttttgtc ccttcccgaa caatatgcag tagctttaag ccattcaagc   6120

tccattatgc agtatatctg agaagggaaa ggaaacaacc catttaaatt tgaataaaac   6180

cgtgcctatg cgaacagtag caatttagaa tctcttttct gcttttaaaa taatttatat   6240

ttaaaaattg cactttagct ttttgatccc tttgtatttc tcttattctc tttctaacct   6300

cttctctgtc ctcaaacttg cctttgctct cctttacaat accccccacc cctcctccaa   6360

ggctctgagc ggcatcattt aaaatacttt acagatattt gcaccaggta catttatgtg   6420

cgtccattgg tagcacagct gagacctgtg tctcacatca gcctaggtga agcctactac   6480

aagaatgcca aggagaagag ccagtacact atatggttta tactctttat ccctttattc   6540

atagcatgtt ttttaaaaat gttatattat gcaacagatg tgaggcagca gctaagctat   6600

acttaagaat tttctctcac cttccaaacc aaagtgtcct gaataagcca ggagacttat   6660

tcttttgtgc accctggtgc acatctgact gttgtcctag ccatagactc tctgaggcca   6720

ctgaaagaac agtggcccta tcgatttcat tcctaggtct caaaaataca atgttgcctt   6780

gtaacataat tagggacagc acctctattt cacaattata atctaaggta ggataagacg   6840

acacagcagc aataaactta caagtaaaat tcaataccaa aacaaacaca aagaaattta   6900

aaaaacaaaa aacctagctc atcatgttgt gaaaatgaaa aagtgaatgt ccattcaaaa   6960

tattttacta tttcttgtgg agtttttcag tgatgtaatg cttgtagcca aattgcttaa   7020

agagtgttta tatatttttt tccttataaa ttgtctattt tttaaaaaag ctatttaacc   7080

acagctgaag tggggggtaa ggccaaattg ccaacacttg ttaaaagatt aatactctta   7140

agtggcactc tgataccttt ccaacttgtc atcagaaagg aatcaataat taccaactgt   7200

tgtatttaga ccaacttaca atatctagct cattagaagc caggatctag aaagctcctt   7260

ctaagccatt taagatattc ttacattgag cttcatatta tagaacttta taggattgga   7320

tattttacaa tagaataatt tagcctcagg actgagaatg tggaagctga ataaattagc   7380

tttaaataca tcattaaaat cttatgcaca ataagctcat tagattctag ttttctcctt   7440

tagaatacca atgccacaga cactacagga gataatgaaa ggtatcagtt gtgttgagtg   7500

gagggagttt aagagaaagg acccttccca accagcagcc agtagaaaat acaacctact   7560

cacctttttc ccttctaagt tctgctaaat cacatctgcc tcatagagaa aggaatgttg   7620

cctttgagaa ctgtcttgga gaacagataa gcttgaaatg ttctctctag agaggacata   7680

gggtttggga tcctctgaaa aggcccagaa aaatagctca gttcaaatac aatgttctag   7740

gacaattgga atataaatat tgtccaaaaa tataattaaa agaaaaaagt ttagcactgt   7800

gtaaagtaag tgttaactga ggaagtccca aaaaggtgct gtcactttaa gttctggact   7860

tggggttctt tgtatttgta aacagcaaag catttgtgtt tgtttgtcta tttgtaaagc   7920

aaccaccttc cttattggaa ggagaaaaaa aggggtacat acatgtaaat acttgctgca   7980

gcatttaata tgtttaattt tgtgttaagc tttttgttgc atcgtgaaca catttattgt   8040

taccaatgga caatgagttc attaagactg ttcaactagg tcagattttt acatctcttt   8100

ctagcaagaa gagacaagat tttgtgcatt tgtacaaatg ttaatatcac tgcaattcca   8160

atataataaa gcactcaaat gcaaataat                                     8189


<210>  3609
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  3609

Met Ile His Arg His Lys His Glu Met Thr Leu Lys Phe Pro Ser Ile 
1               5                   10                  15


Lys Thr Asp Asn Met Leu Ser Asp Gln Thr Pro Thr Pro Thr Arg Phe 
            20                  25                  30


Leu Lys Asn Cys Glu Glu Val Gly Leu Phe Ser Glu Leu Asp Cys Ser 
        35                  40                  45


Leu Glu His Glu Phe Arg Lys Ala Gln Glu Glu Glu Ser Ser Lys Arg 
    50                  55                  60


Asn Ile Ser Met His Asn Ala Val Gly Gly Ala Met Thr Gly Pro Gly 
65                  70                  75                  80


Thr His Gln Leu Ser Ser Ala Arg Leu Pro Asn His Asp Thr Asn Val 
                85                  90                  95


Val Ile Gln Gln Ala Met Pro Ser Pro Gln Ser Ser Ser Val Ile Thr 
            100                 105                 110


Gln Ala Pro Ser Thr Asn Arg Gln Ile Gly Pro Val Pro Gly Ser Leu 
        115                 120                 125


Ser Ser Leu Leu His Leu His Asn Arg Gln Arg Gln Pro Met Pro Ala 
    130                 135                 140


Ser Met Pro Gly Thr Leu Pro Asn Pro Thr Met Pro Gly Ser Ser Ala 
145                 150                 155                 160


Val Leu Met Pro Met Glu Arg Gln Met Ser Val Asn Ser Ser Ile Met 
                165                 170                 175


Gly Met Gln Gly Pro Asn Leu Ser Asn Pro Cys Ala Ser Pro Gln Val 
            180                 185                 190


Gln Pro Met His Ser Glu Ala Lys Met Arg Leu Lys Ala Ala Leu Thr 
        195                 200                 205


His His Pro Ala Ala Met Ser Asn Gly Asn Met Asn Thr Met Gly His 
    210                 215                 220


Met Met Glu Met Met Gly Ser Arg Gln Asp Gln Thr Pro His His His 
225                 230                 235                 240


Met His Ser His Pro His Gln His Gln Thr Leu Pro Pro His His Pro 
                245                 250                 255


Tyr Pro His Gln His Gln His Pro Ala His His Pro His Pro Gln Pro 
            260                 265                 270


His His Gln Gln Asn His Pro His His His Ser His Ser His Leu His 
        275                 280                 285


Ala His Pro Ala His His Gln Thr Ser Pro His Pro Pro Leu His Thr 
    290                 295                 300


Gly Asn Gln Ala Gln Val Ser Pro Ala Thr Gln Gln Met Gln Pro Thr 
305                 310                 315                 320


Gln Thr Ile Gln Pro Pro Gln Pro Thr Gly Gly Arg Arg Arg Arg Val 
                325                 330                 335


Val Asp Glu Asp Pro Asp Glu Arg Arg Arg Lys Phe Leu Glu Arg Asn 
            340                 345                 350


Arg Ala Ala Ala Thr Arg Cys Arg Gln Lys Arg Lys Val Trp Val Met 
        355                 360                 365


Ser Leu Glu Lys Lys Ala Glu Glu Leu Thr Gln Thr Asn Met Gln Leu 
    370                 375                 380


Gln Asn Glu Val Ser Met Leu Lys Asn Glu Val Ala Gln Leu Lys Gln 
385                 390                 395                 400


Leu Leu Leu Thr His Lys Asp Cys Pro Ile Thr Ala Met Gln Lys Glu 
                405                 410                 415


Ser Gln Gly Tyr Leu Ser Pro Glu Ser Ser Pro Pro Ala Ser Pro Val 
            420                 425                 430


Pro Ala Cys Ser Gln Gln Gln Val Ile Gln His Asn Thr Ile Thr Thr 
        435                 440                 445


Ser Ser Ser Val Ser Glu Val Val Gly Ser Ser Thr Leu Ser Gln Leu 
    450                 455                 460


Thr Thr His Arg Thr Asp Leu Asn Pro Ile Leu 
465                 470                 475


<210>  3610
<211>  8638
<212>  DNA
<213>  Homo sapiens

<400>  3610
ggagattgca gcttgctaac tagatggcgc actgttattt ggtgttctct gctgcgtagc     60

gcaggagtat aaactgagca tgtagctgct tgcgaggtgt tcttcaacat ttacaacaaa    120

gttgattctg tgtagggttg gaggctagac agttccacaa atttttagtc acattttcca    180

tgtcagttaa atctagggag ttcaagacta ctggaaaaat tagtctcatt actaaaagaa    240

acttagagaa cgagggaggt accagagtct aggaggtacc tctgggttgc agaagtaatt    300

gtaaaatacc agacctgttc tttttactaa aagctagttt cactatcttc tggtctgaaa    360

tactgaggca aatactcaag acttattttc ttcctaatct tgctggtgaa acagaagtta    420

ctagaaagaa aggaagaaaa aacttgattt ggtgactgca ggaagcaaca cgttgctgct    480

tttattctac agataatgat ttatgaggaa tccaagatga atttggagca ggagaggccg    540

tttgtctgca gtgccccagg ctgctcccag cgcttcccaa cagaggacca tctgatgatt    600

cataggcaca aacatgaaat gactttgaag tttccttcaa taaaaacaga caatatgtta    660

tcagatcaaa ctccgacccc aacgagattc ctgaagaact gcgaggaggt gggcctcttc    720

agcgagctgg actgctccct ggagcacgag ttcaggaagg ctcaggaaga ggagagcagc    780

aagcggaata tctcgatgca taatgcagtt ggtggggcca tgacggggcc cggaactcac    840

cagcttagca gcgctcggct gcccaaccat gacaccaacg ttgtgattca gcaagccatg    900

ccgtcgcctc agtccagctc tgtcatcact caggcacctt ccaccaaccg ccagatcggg    960

cctgtcccag gctctctatc ttctctgcta catctccaca acagacagag acagcccatg   1020

ccagcctcca tgcctgggac cctgcccaac cctacaatgc caggatcttc cgccgtcttg   1080

atgccaatgg agcgacaaat gtcagtgaac tccagcatca tggggatgca aggtccaaat   1140

ctcagcaacc cctgtgcttc tccccaggtc cagccaatgc attcagaagc caaaatgagg   1200

ttgaaggctg cattgactca ccaccctgct gccatgtcaa atgggaacat gaacaccatg   1260

ggacacatga tggagatgat gggctcccgg caggaccaga cgccacacca tcacatgcac   1320

tcgcacccgc atcagcacca gacactgcca ccccatcacc cttacccaca ccagcaccag   1380

cacccagcac accatcctca ccctcaaccc catcaccagc agaaccatcc acatcaccac   1440

tcccattccc accttcatgc acacccagca catcaccaga cctcgccaca tccgcccctg   1500

cacaccggca accaagcaca ggtttcacca gcaacacaac agatgcagcc aacccagaca   1560

atacagccac cccagcccac aggggggcgc cggcgaaggg tggtagacga ggatccggac   1620

gagaggcggc ggaaatttct ggaacggaac cgggcagctg ccacccgctg cagacagaag   1680

aggaaggtct gggtgatgtc attggaaaag aaagcagaag aactcaccca gacaaacatg   1740

cagcttcaga atgaagtgtc tatgttgaaa aatgaggtgg cccagctgaa acagttgttg   1800

ttaacacata aagactgccc aataacagcc atgcagaaag aatcacaagg atatctaagt   1860

ccagagagta gccctcctgc tagtcctgtc ccagcttgct cccagcaaca agtcatccag   1920

cataatacca tcactacttc ctcatcggtc agcgaggtgg taggaagctc caccctcagc   1980

cagctcacca ctcacagaac agacctgaat ccgattcttt aaaatgcacc atcagacctg   2040

gcctccaaga agagctgtag cgtaccatgc gtcctttctt ttaagggcat ttttagaatt   2100

aactcagacc tggaagactc ctcagttctt caaagactgg ctttcatttt tatagttatt   2160

atggaaatgt tgtcttttat acttagttat ataagaaaaa agggagttat gcaattaata   2220

tctatcagct tgggaaacgc tttggtgctt ttctccagtt ttctggtacc agttacttgt   2280

ttataaactg aaccttttct gtatatagcc atggtttcat tcttatcagt ccaacccttt   2340

gcctgaaaca ttgaatcttg ttaaaccaca gcttttagct aaaatgaggt atacctagat   2400

gtcaagtaag acagatccaa ggtaactggg taggaaatct tttgacatct taactcatgt   2460

tgagtttgtg ctgtggtgtc accagaattc cagataaaca cacagccttt cccatacctt   2520

tttttttctt actataaaat attataagat ccattgatgt ccaaataata ccaccaagca   2580

tctcttcacc tctcctcctc ttggtccact tgctaatgcc cagttttctt ctccatttcc   2640

actttttctt aggctcccta tttactattc attttgactt ccttctgttt tatttttttc   2700

cctttagcat tgcatgtgaa taagaaaata atgtttaaag aaaaaaaaaa aaaagcaaac   2760

ctccaaaacg tggacctaac cattgcttca cttacacttc acccacagct ggagttcatt   2820

caactcttgc ttttcacaaa atagtaacca ggagatgttt aatgtgcctg atttaatgtt   2880

tttaataatc acagcaaatg aaaggtggtt tagttataag tgaagcatgg ttgaatacca   2940

gctggggaga cactagggaa gggagctttg taagccttga ttgcgaaagt ccaaattttg   3000

atgtggggct ataacatgac acccttggat tgcgactggt tttatacggc ctgcctataa   3060

cgttgaaaat ccatgtacta cataataatt cagaagggct ctattcacta cacagattac   3120

attgttcaat catcagctgc taatagccta agatttattt tttttttttt cttaagccta   3180

tggaaccggc tttgctgttc tggggggtga aaatagacta actactggag aaacaaagag   3240

agaaagaaaa cccagtgttt ccataggggc acttttagcc ttcccacaac agttaagcac   3300

tctttgactg ctgaaggaac cccatggatg aggtgcaggc tacttcactc tttttttttc   3360

ttttttgaga cagagtctca cctattgccc agactgaagt gcagtggtgc gatcatggat   3420

cactgcagca gcatcctccg agttcaagct atccttccac ctccgcctcc tgagtagctg   3480

ggaccacagg ttcacataac catgcctggc taatttattt ttacttttat tttaaaataa   3540

aagatgaggt ctgtcttatg ttgcccaggc tggtctcaaa ctatcctact tcttcctccc   3600

aaagtgttgg gattataggt gtgagccact gcacccagcc tacttcactc ttctgaatta   3660

ttctgattta ttttcaacaa cttttgtgaa cttgcccgtg atacaaagca gatagtccct   3720

gaaccacagt cgtgcctcct tgaaacaagc cattctactg tgctaatgtt ttaatatcac   3780

atctcacaaa taacaggggt gaatgtttct ctctagcaat ctaggcaggt gctggtgttt   3840

catctccatt tgaatgcttg acctcttaat gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt   3900

gttcatgggt tttaaaagaa cagtatttta caaaaggtgt agcttttata agagtgcaga   3960

aaagggaagg atgtgttttt ttctctcact atagtataag aatctatttt ggagaaaaaa   4020

agaaaatatg agggtctcga agcatgattt ttatataact agtttcagtt ttatctaata   4080

acttactttt taaatcaata tttatcaaca atctttcctt gtatgcagtg ctttcaaaag   4140

atggttttga gtgtccagtg aaacttatga cttggatata tggttgaaga atcaaaacaa   4200

aagcaaaaaa aaaaagcaaa aaaagaaaag agaaaaaaag aaaaaatgca aatggaataa   4260

ttttctatta tattttagac aaacatatca ttttcgagta ttttaaatac tgaattcata   4320

gttgttgttt tttaaattcc aacagtaaca gctgaatggt ttaatctgac tggcttccta   4380

agaaatgttt aagactcagc tttaaaaaga agttaacatt catatctctg ttttgaaatc   4440

aaaaatcata tttcaaaatt ctttcctagg accatctatg tgtctcccct cccctccaca   4500

aaaaggagaa agagtgcatt aaaatgttta gttgggtttt ttaattttta atttttatgt   4560

tatgttttgc tttgttttaa gtaaacaaaa atttttcttt ctttactgca tgcatagcac   4620

ttaataaaat ggatttttaa aaaatccact agtaatatca gaatgtccag ggagtgactg   4680

tcactacaat gatggtttag tttacttctg ttccaccttt tgattgaaat atttagttgt   4740

taggctgaaa gcctcggcag ttaagaactt gcctgagttt tcttcgttca gcaacttgac   4800

agtttgactg atgtgcatta tatatagctc aattatgtct gttttttatg ctaagtagga   4860

aaaccaacca cacacattag caaaccggcc tcaacatata attagaataa actgtcttct   4920

tgttctactc agggccttta ggtgtgttca ttcacggtat ggaaatacag taaatgaaag   4980

attccaacta gttgtcagtg cttcttgaaa ttccaaacag aaagatacat tggtcaaatc   5040

caacacttgg cttatcaata ttaagtcttt tacctaaagg cccagccgtc accagacaac   5100

agaataatca atctgcctga aaatccctcc tccttgtcct acactttttg cctgtttggg   5160

agaatatctt tgtactccat tctcctccct cagccagtta ctgggtcacc catccatgtg   5220

ttcatgaatc aatcatcacg gcctgcagag cacctgtcct aaggagggaa aatcctgtca   5280

cactgcctct ccccattcgt gtgtggtttt cttgatcggt gagatctgtc tctgaagtca   5340

ctgccagcct ccctgggaac gtctatagtg cctcccctgc cttatgtgat gggagttaac   5400

aactcagata agtacacctg agagcatttc tatcaggtaa actgtcactt aaatggaggt   5460

gtccacatct taattgtttc tccttgacac atttctcaat ccacgaagcc aggagaggta   5520

gagtgaaaat cccagccatg gatgaatgta ctaatttgaa agccaagtgt taagtcggat   5580

gttttcccgt tacactacta ctcagccctc tcctgcggcc acatcaacgg atgcaagtca   5640

cagtcttaac acagcctgtg ggagacaagc agtttgtgtg ctcacagtat atattatagt   5700

aattagggtg acttagagca aatactcttc agatcctatg tagtcagtga aacaaaatgg   5760

agagcgtatt ctgatagaag gacgtcgacg gtgaatgttc tggtggttgt tgcctgttaa   5820

gtaaacttta gtgtgtaagt tgagtttgtc attaaaatca taaaccagct gcggtaacag   5880

acaagccttt ggctggggag ttttaagcct cggtaactgc tataaaacta gccatccagt   5940

taggatagaa tgtgtttctt tctggttaaa aaaaggaaaa accatctaag aaaatatata   6000

tgtatgtatg tgtgtataca gtggaattca aaggaccaaa gcaaaatttg aacaggaatc   6060

tattaattta gaattttata agatatttat taataaatgt tatttttaaa cattccattt   6120

gaacagtatt ctgtaggatc tacttgtttt taaagtgtta gtccataata aactactata   6180

gttatgtgta ttttcatttt tcagggtttc aaatggctat tctccatcat ttggtggaaa   6240

tgtttgctta gatctctgtg catagacatt tcaaggattt ttattgctct gtgagttatt   6300

ttttaatcaa cattctgaac agtttttttt aaacatttat ttctgtgtgt tcatttttaa   6360

agtaagctct ttcatttagg aagcagagtt cagctaaagg gaatcagtaa ctctaactgg   6420

aacagctttc ttgtagaagt gtaaaaacag cttcatctct gcctctctcc accccacccc   6480

aatttcctag aaagccttgc actattcagc tcccttagtg ctttttgtcc cttcccgaac   6540

aatatgcagt agctttaagc cattcaagct ccattatgca gtatatctga gaagggaaag   6600

gaaacaaccc atttaaattt gaataaaacc gtgcctatgc gaacagtagc aatttagaat   6660

ctcttttctg cttttaaaat aatttatatt taaaaattgc actttagctt tttgatccct   6720

ttgtatttct cttattctct ttctaacctc ttctctgtcc tcaaacttgc ctttgctctc   6780

ctttacaata ccccccaccc ctcctccaag gctctgagcg gcatcattta aaatacttta   6840

cagatatttg caccaggtac atttatgtgc gtccattggt agcacagctg agacctgtgt   6900

ctcacatcag cctaggtgaa gcctactaca agaatgccaa ggagaagagc cagtacacta   6960

tatggtttat actctttatc cctttattca tagcatgttt tttaaaaatg ttatattatg   7020

caacagatgt gaggcagcag ctaagctata cttaagaatt ttctctcacc ttccaaacca   7080

aagtgtcctg aataagccag gagacttatt cttttgtgca ccctggtgca catctgactg   7140

ttgtcctagc catagactct ctgaggccac tgaaagaaca gtggccctat cgatttcatt   7200

cctaggtctc aaaaatacaa tgttgccttg taacataatt agggacagca cctctatttc   7260

acaattataa tctaaggtag gataagacga cacagcagca ataaacttac aagtaaaatt   7320

caataccaaa acaaacacaa agaaatttaa aaaacaaaaa acctagctca tcatgttgtg   7380

aaaatgaaaa agtgaatgtc cattcaaaat attttactat ttcttgtgga gtttttcagt   7440

gatgtaatgc ttgtagccaa attgcttaaa gagtgtttat atattttttt ccttataaat   7500

tgtctatttt ttaaaaaagc tatttaacca cagctgaagt ggggggtaag gccaaattgc   7560

caacacttgt taaaagatta atactcttaa gtggcactct gatacctttc caacttgtca   7620

tcagaaagga atcaataatt accaactgtt gtatttagac caacttacaa tatctagctc   7680

attagaagcc aggatctaga aagctccttc taagccattt aagatattct tacattgagc   7740

ttcatattat agaactttat aggattggat attttacaat agaataattt agcctcagga   7800

ctgagaatgt ggaagctgaa taaattagct ttaaatacat cattaaaatc ttatgcacaa   7860

taagctcatt agattctagt tttctccttt agaataccaa tgccacagac actacaggag   7920

ataatgaaag gtatcagttg tgttgagtgg agggagttta agagaaagga cccttcccaa   7980

ccagcagcca gtagaaaata caacctactc acctttttcc cttctaagtt ctgctaaatc   8040

acatctgcct catagagaaa ggaatgttgc ctttgagaac tgtcttggag aacagataag   8100

cttgaaatgt tctctctaga gaggacatag ggtttgggat cctctgaaaa ggcccagaaa   8160

aatagctcag ttcaaataca atgttctagg acaattggaa tataaatatt gtccaaaaat   8220

ataattaaaa gaaaaaagtt tagcactgtg taaagtaagt gttaactgag gaagtcccaa   8280

aaaggtgctg tcactttaag ttctggactt ggggttcttt gtatttgtaa acagcaaagc   8340

atttgtgttt gtttgtctat ttgtaaagca accaccttcc ttattggaag gagaaaaaaa   8400

ggggtacata catgtaaata cttgctgcag catttaatat gtttaatttt gtgttaagct   8460

ttttgttgca tcgtgaacac atttattgtt accaatggac aatgagttca ttaagactgt   8520

tcaactaggt cagattttta catctctttc tagcaagaag agacaagatt ttgtgcattt   8580

gtacaaatgt taatatcact gcaattccaa tataataaag cactcaaatg caaataat     8638


<210>  3611
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  3611

Met Ile Tyr Glu Glu Ser Lys Met Asn Leu Glu Gln Glu Arg Pro Phe 
1               5                   10                  15


Val Cys Ser Ala Pro Gly Cys Ser Gln Arg Phe Pro Thr Glu Asp His 
            20                  25                  30


Leu Met Ile His Arg His Lys His Glu Met Thr Leu Lys Phe Pro Ser 
        35                  40                  45


Ile Lys Thr Asp Asn Met Leu Ser Asp Gln Thr Pro Thr Pro Thr Arg 
    50                  55                  60


Phe Leu Lys Asn Cys Glu Glu Val Gly Leu Phe Ser Glu Leu Asp Cys 
65                  70                  75                  80


Ser Leu Glu His Glu Phe Arg Lys Ala Gln Glu Glu Glu Ser Ser Lys 
                85                  90                  95


Arg Asn Ile Ser Met His Asn Ala Val Gly Gly Ala Met Thr Gly Pro 
            100                 105                 110


Gly Thr His Gln Leu Ser Ser Ala Arg Leu Pro Asn His Asp Thr Asn 
        115                 120                 125


Val Val Ile Gln Gln Ala Met Pro Ser Pro Gln Ser Ser Ser Val Ile 
    130                 135                 140


Thr Gln Ala Pro Ser Thr Asn Arg Gln Ile Gly Pro Val Pro Gly Ser 
145                 150                 155                 160


Leu Ser Ser Leu Leu His Leu His Asn Arg Gln Arg Gln Pro Met Pro 
                165                 170                 175


Ala Ser Met Pro Gly Thr Leu Pro Asn Pro Thr Met Pro Gly Ser Ser 
            180                 185                 190


Ala Val Leu Met Pro Met Glu Arg Gln Met Ser Val Asn Ser Ser Ile 
        195                 200                 205


Met Gly Met Gln Gly Pro Asn Leu Ser Asn Pro Cys Ala Ser Pro Gln 
    210                 215                 220


Val Gln Pro Met His Ser Glu Ala Lys Met Arg Leu Lys Ala Ala Leu 
225                 230                 235                 240


Thr His His Pro Ala Ala Met Ser Asn Gly Asn Met Asn Thr Met Gly 
                245                 250                 255


His Met Met Glu Met Met Gly Ser Arg Gln Asp Gln Thr Pro His His 
            260                 265                 270


His Met His Ser His Pro His Gln His Gln Thr Leu Pro Pro His His 
        275                 280                 285


Pro Tyr Pro His Gln His Gln His Pro Ala His His Pro His Pro Gln 
    290                 295                 300


Pro His His Gln Gln Asn His Pro His His His Ser His Ser His Leu 
305                 310                 315                 320


His Ala His Pro Ala His His Gln Thr Ser Pro His Pro Pro Leu His 
                325                 330                 335


Thr Gly Asn Gln Ala Gln Val Ser Pro Ala Thr Gln Gln Met Gln Pro 
            340                 345                 350


Thr Gln Thr Ile Gln Pro Pro Gln Pro Thr Gly Gly Arg Arg Arg Arg 
        355                 360                 365


Val Val Asp Glu Asp Pro Asp Glu Arg Arg Arg Lys Phe Leu Glu Arg 
    370                 375                 380


Asn Arg Ala Ala Ala Thr Arg Cys Arg Gln Lys Arg Lys Val Trp Val 
385                 390                 395                 400


Met Ser Leu Glu Lys Lys Ala Glu Glu Leu Thr Gln Thr Asn Met Gln 
                405                 410                 415


Leu Gln Asn Glu Val Ser Met Leu Lys Asn Glu Val Ala Gln Leu Lys 
            420                 425                 430


Gln Leu Leu Leu Thr His Lys Asp Cys Pro Ile Thr Ala Met Gln Lys 
        435                 440                 445


Glu Ser Gln Gly Tyr Leu Ser Pro Glu Ser Ser Pro Pro Ala Ser Pro 
    450                 455                 460


Val Pro Ala Cys Ser Gln Gln Gln Val Ile Gln His Asn Thr Ile Thr 
465                 470                 475                 480


Thr Ser Ser Ser Val Ser Glu Val Val Gly Ser Ser Thr Leu Ser Gln 
                485                 490                 495


Leu Thr Thr His Arg Thr Asp Leu Asn Pro Ile Leu 
            500                 505


<210>  3612
<211>  8210
<212>  DNA
<213>  Homo sapiens

<400>  3612
agtggtggag tcaatttatt tctgaaacga tctcatttac ctgaatgagg agctcatatt     60

tattttcagg atttatgagg aatccaagat gaatttggag caggagaggc cgtttgtctg    120

cagtgcccca ggctgctccc agcgcttccc aacagaggac catctgatga ttcataggca    180

caaacatgaa atgactttga agtttccttc aataaaaaca gacaatatgt tatcagatca    240

aactccgacc ccaacgagat tcctgaagaa ctgcgaggag gtgggcctct tcagcgagct    300

ggactgctcc ctggagcacg agttcaggaa ggctcaggaa gaggagagca gcaagcggaa    360

tatctcgatg cataatgcag ttggtggggc catgacgggg cccggaactc accagcttag    420

cagcgctcgg ctgcccaacc atgacaccaa cgttgtgatt cagcaagcca tgccgtcgcc    480

tcagtccagc tctgtcatca ctcaggcacc ttccaccaac cgccagatcg ggcctgtccc    540

aggctctcta tcttctctgc tacatctcca caacagacag agacagccca tgccagcctc    600

catgcctggg accctgccca accctacaat gccaggatct tccgccgtct tgatgccaat    660

ggagcgacaa atgtcagtga actccagcat catggggatg caaggtccaa atctcagcaa    720

cccctgtgct tctccccagg tccagccaat gcattcagaa gccaaaatga ggttgaaggc    780

tgcattgact caccaccctg ctgccatgtc aaatgggaac atgaacacca tgggacacat    840

gatggagatg atgggctccc ggcaggacca gacgccacac catcacatgc actcgcaccc    900

gcatcagcac cagacactgc caccccatca cccttaccca caccagcacc agcacccagc    960

acaccatcct caccctcaac cccatcacca gcagaaccat ccacatcacc actcccattc   1020

ccaccttcat gcacacccag cacatcacca gacctcgcca catccgcccc tgcacaccgg   1080

caaccaagca caggtttcac cagcaacaca acagatgcag ccaacccaga caatacagcc   1140

accccagccc acaggggggc gccggcgaag ggtggtagac gaggatccgg acgagaggcg   1200

gcggaaattt ctggaacgga accgggcagc tgccacccgc tgcagacaga agaggaaggt   1260

ctgggtgatg tcattggaaa agaaagcaga agaactcacc cagacaaaca tgcagcttca   1320

gaatgaagtg tctatgttga aaaatgaggt ggcccagctg aaacagttgt tgttaacaca   1380

taaagactgc ccaataacag ccatgcagaa agaatcacaa ggatatctaa gtccagagag   1440

tagccctcct gctagtcctg tcccagcttg ctcccagcaa caagtcatcc agcataatac   1500

catcactact tcctcatcgg tcagcgaggt ggtaggaagc tccaccctca gccagctcac   1560

cactcacaga acagacctga atccgattct ttaaaatgca ccatcagacc tggcctccaa   1620

gaagagctgt agcgtaccat gcgtcctttc ttttaagggc atttttagaa ttaactcaga   1680

cctggaagac tcctcagttc ttcaaagact ggctttcatt tttatagtta ttatggaaat   1740

gttgtctttt atacttagtt atataagaaa aaagggagtt atgcaattaa tatctatcag   1800

cttgggaaac gctttggtgc ttttctccag ttttctggta ccagttactt gtttataaac   1860

tgaacctttt ctgtatatag ccatggtttc attcttatca gtccaaccct ttgcctgaaa   1920

cattgaatct tgttaaacca cagcttttag ctaaaatgag gtatacctag atgtcaagta   1980

agacagatcc aaggtaactg ggtaggaaat cttttgacat cttaactcat gttgagtttg   2040

tgctgtggtg tcaccagaat tccagataaa cacacagcct ttcccatacc tttttttttc   2100

ttactataaa atattataag atccattgat gtccaaataa taccaccaag catctcttca   2160

cctctcctcc tcttggtcca cttgctaatg cccagttttc ttctccattt ccactttttc   2220

ttaggctccc tatttactat tcattttgac ttccttctgt tttatttttt tccctttagc   2280

attgcatgtg aataagaaaa taatgtttaa agaaaaaaaa aaaaaagcaa acctccaaaa   2340

cgtggaccta accattgctt cacttacact tcacccacag ctggagttca ttcaactctt   2400

gcttttcaca aaatagtaac caggagatgt ttaatgtgcc tgatttaatg tttttaataa   2460

tcacagcaaa tgaaaggtgg tttagttata agtgaagcat ggttgaatac cagctgggga   2520

gacactaggg aagggagctt tgtaagcctt gattgcgaaa gtccaaattt tgatgtgggg   2580

ctataacatg acacccttgg attgcgactg gttttatacg gcctgcctat aacgttgaaa   2640

atccatgtac tacataataa ttcagaaggg ctctattcac tacacagatt acattgttca   2700

atcatcagct gctaatagcc taagatttat tttttttttt ttcttaagcc tatggaaccg   2760

gctttgctgt tctggggggt gaaaatagac taactactgg agaaacaaag agagaaagaa   2820

aacccagtgt ttccataggg gcacttttag ccttcccaca acagttaagc actctttgac   2880

tgctgaagga accccatgga tgaggtgcag gctacttcac tctttttttt tcttttttga   2940

gacagagtct cacctattgc ccagactgaa gtgcagtggt gcgatcatgg atcactgcag   3000

cagcatcctc cgagttcaag ctatccttcc acctccgcct cctgagtagc tgggaccaca   3060

ggttcacata accatgcctg gctaatttat ttttactttt attttaaaat aaaagatgag   3120

gtctgtctta tgttgcccag gctggtctca aactatccta cttcttcctc ccaaagtgtt   3180

gggattatag gtgtgagcca ctgcacccag cctacttcac tcttctgaat tattctgatt   3240

tattttcaac aacttttgtg aacttgcccg tgatacaaag cagatagtcc ctgaaccaca   3300

gtcgtgcctc cttgaaacaa gccattctac tgtgctaatg ttttaatatc acatctcaca   3360

aataacaggg gtgaatgttt ctctctagca atctaggcag gtgctggtgt ttcatctcca   3420

tttgaatgct tgacctctta atgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgttcatgg   3480

gttttaaaag aacagtattt tacaaaaggt gtagctttta taagagtgca gaaaagggaa   3540

ggatgtgttt ttttctctca ctatagtata agaatctatt ttggagaaaa aaagaaaata   3600

tgagggtctc gaagcatgat ttttatataa ctagtttcag ttttatctaa taacttactt   3660

tttaaatcaa tatttatcaa caatctttcc ttgtatgcag tgctttcaaa agatggtttt   3720

gagtgtccag tgaaacttat gacttggata tatggttgaa gaatcaaaac aaaagcaaaa   3780

aaaaaaagca aaaaaagaaa agagaaaaaa agaaaaaatg caaatggaat aattttctat   3840

tatattttag acaaacatat cattttcgag tattttaaat actgaattca tagttgttgt   3900

tttttaaatt ccaacagtaa cagctgaatg gtttaatctg actggcttcc taagaaatgt   3960

ttaagactca gctttaaaaa gaagttaaca ttcatatctc tgttttgaaa tcaaaaatca   4020

tatttcaaaa ttctttccta ggaccatcta tgtgtctccc ctcccctcca caaaaaggag   4080

aaagagtgca ttaaaatgtt tagttgggtt ttttaatttt taatttttat gttatgtttt   4140

gctttgtttt aagtaaacaa aaatttttct ttctttactg catgcatagc acttaataaa   4200

atggattttt aaaaaatcca ctagtaatat cagaatgtcc agggagtgac tgtcactaca   4260

atgatggttt agtttacttc tgttccacct tttgattgaa atatttagtt gttaggctga   4320

aagcctcggc agttaagaac ttgcctgagt tttcttcgtt cagcaacttg acagtttgac   4380

tgatgtgcat tatatatagc tcaattatgt ctgtttttta tgctaagtag gaaaaccaac   4440

cacacacatt agcaaaccgg cctcaacata taattagaat aaactgtctt cttgttctac   4500

tcagggcctt taggtgtgtt cattcacggt atggaaatac agtaaatgaa agattccaac   4560

tagttgtcag tgcttcttga aattccaaac agaaagatac attggtcaaa tccaacactt   4620

ggcttatcaa tattaagtct tttacctaaa ggcccagccg tcaccagaca acagaataat   4680

caatctgcct gaaaatccct cctccttgtc ctacactttt tgcctgtttg ggagaatatc   4740

tttgtactcc attctcctcc ctcagccagt tactgggtca cccatccatg tgttcatgaa   4800

tcaatcatca cggcctgcag agcacctgtc ctaaggaggg aaaatcctgt cacactgcct   4860

ctccccattc gtgtgtggtt ttcttgatcg gtgagatctg tctctgaagt cactgccagc   4920

ctccctggga acgtctatag tgcctcccct gccttatgtg atgggagtta acaactcaga   4980

taagtacacc tgagagcatt tctatcaggt aaactgtcac ttaaatggag gtgtccacat   5040

cttaattgtt tctccttgac acatttctca atccacgaag ccaggagagg tagagtgaaa   5100

atcccagcca tggatgaatg tactaatttg aaagccaagt gttaagtcgg atgttttccc   5160

gttacactac tactcagccc tctcctgcgg ccacatcaac ggatgcaagt cacagtctta   5220

acacagcctg tgggagacaa gcagtttgtg tgctcacagt atatattata gtaattaggg   5280

tgacttagag caaatactct tcagatccta tgtagtcagt gaaacaaaat ggagagcgta   5340

ttctgataga aggacgtcga cggtgaatgt tctggtggtt gttgcctgtt aagtaaactt   5400

tagtgtgtaa gttgagtttg tcattaaaat cataaaccag ctgcggtaac agacaagcct   5460

ttggctgggg agttttaagc ctcggtaact gctataaaac tagccatcca gttaggatag   5520

aatgtgtttc tttctggtta aaaaaaggaa aaaccatcta agaaaatata tatgtatgta   5580

tgtgtgtata cagtggaatt caaaggacca aagcaaaatt tgaacaggaa tctattaatt   5640

tagaatttta taagatattt attaataaat gttattttta aacattccat ttgaacagta   5700

ttctgtagga tctacttgtt tttaaagtgt tagtccataa taaactacta tagttatgtg   5760

tattttcatt tttcagggtt tcaaatggct attctccatc atttggtgga aatgtttgct   5820

tagatctctg tgcatagaca tttcaaggat ttttattgct ctgtgagtta ttttttaatc   5880

aacattctga acagtttttt ttaaacattt atttctgtgt gttcattttt aaagtaagct   5940

ctttcattta ggaagcagag ttcagctaaa gggaatcagt aactctaact ggaacagctt   6000

tcttgtagaa gtgtaaaaac agcttcatct ctgcctctct ccaccccacc ccaatttcct   6060

agaaagcctt gcactattca gctcccttag tgctttttgt cccttcccga acaatatgca   6120

gtagctttaa gccattcaag ctccattatg cagtatatct gagaagggaa aggaaacaac   6180

ccatttaaat ttgaataaaa ccgtgcctat gcgaacagta gcaatttaga atctcttttc   6240

tgcttttaaa ataatttata tttaaaaatt gcactttagc tttttgatcc ctttgtattt   6300

ctcttattct ctttctaacc tcttctctgt cctcaaactt gcctttgctc tcctttacaa   6360

taccccccac ccctcctcca aggctctgag cggcatcatt taaaatactt tacagatatt   6420

tgcaccaggt acatttatgt gcgtccattg gtagcacagc tgagacctgt gtctcacatc   6480

agcctaggtg aagcctacta caagaatgcc aaggagaaga gccagtacac tatatggttt   6540

atactcttta tccctttatt catagcatgt tttttaaaaa tgttatatta tgcaacagat   6600

gtgaggcagc agctaagcta tacttaagaa ttttctctca ccttccaaac caaagtgtcc   6660

tgaataagcc aggagactta ttcttttgtg caccctggtg cacatctgac tgttgtccta   6720

gccatagact ctctgaggcc actgaaagaa cagtggccct atcgatttca ttcctaggtc   6780

tcaaaaatac aatgttgcct tgtaacataa ttagggacag cacctctatt tcacaattat   6840

aatctaaggt aggataagac gacacagcag caataaactt acaagtaaaa ttcaatacca   6900

aaacaaacac aaagaaattt aaaaaacaaa aaacctagct catcatgttg tgaaaatgaa   6960

aaagtgaatg tccattcaaa atattttact atttcttgtg gagtttttca gtgatgtaat   7020

gcttgtagcc aaattgctta aagagtgttt atatattttt ttccttataa attgtctatt   7080

ttttaaaaaa gctatttaac cacagctgaa gtggggggta aggccaaatt gccaacactt   7140

gttaaaagat taatactctt aagtggcact ctgatacctt tccaacttgt catcagaaag   7200

gaatcaataa ttaccaactg ttgtatttag accaacttac aatatctagc tcattagaag   7260

ccaggatcta gaaagctcct tctaagccat ttaagatatt cttacattga gcttcatatt   7320

atagaacttt ataggattgg atattttaca atagaataat ttagcctcag gactgagaat   7380

gtggaagctg aataaattag ctttaaatac atcattaaaa tcttatgcac aataagctca   7440

ttagattcta gttttctcct ttagaatacc aatgccacag acactacagg agataatgaa   7500

aggtatcagt tgtgttgagt ggagggagtt taagagaaag gacccttccc aaccagcagc   7560

cagtagaaaa tacaacctac tcaccttttt cccttctaag ttctgctaaa tcacatctgc   7620

ctcatagaga aaggaatgtt gcctttgaga actgtcttgg agaacagata agcttgaaat   7680

gttctctcta gagaggacat agggtttggg atcctctgaa aaggcccaga aaaatagctc   7740

agttcaaata caatgttcta ggacaattgg aatataaata ttgtccaaaa atataattaa   7800

aagaaaaaag tttagcactg tgtaaagtaa gtgttaactg aggaagtccc aaaaaggtgc   7860

tgtcacttta agttctggac ttggggttct ttgtatttgt aaacagcaaa gcatttgtgt   7920

ttgtttgtct atttgtaaag caaccacctt ccttattgga aggagaaaaa aaggggtaca   7980

tacatgtaaa tacttgctgc agcatttaat atgtttaatt ttgtgttaag ctttttgttg   8040

catcgtgaac acatttattg ttaccaatgg acaatgagtt cattaagact gttcaactag   8100

gtcagatttt tacatctctt tctagcaaga agagacaaga ttttgtgcat ttgtacaaat   8160

gttaatatca ctgcaattcc aatataataa agcactcaaa tgcaaataat              8210


<210>  3613
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  3613

Met Asn Leu Glu Gln Glu Arg Pro Phe Val Cys Ser Ala Pro Gly Cys 
1               5                   10                  15


Ser Gln Arg Phe Pro Thr Glu Asp His Leu Met Ile His Arg His Lys 
            20                  25                  30


His Glu Met Thr Leu Lys Phe Pro Ser Ile Lys Thr Asp Asn Met Leu 
        35                  40                  45


Ser Asp Gln Thr Pro Thr Pro Thr Arg Phe Leu Lys Asn Cys Glu Glu 
    50                  55                  60


Val Gly Leu Phe Ser Glu Leu Asp Cys Ser Leu Glu His Glu Phe Arg 
65                  70                  75                  80


Lys Ala Gln Glu Glu Glu Ser Ser Lys Arg Asn Ile Ser Met His Asn 
                85                  90                  95


Ala Val Gly Gly Ala Met Thr Gly Pro Gly Thr His Gln Leu Ser Ser 
            100                 105                 110


Ala Arg Leu Pro Asn His Asp Thr Asn Val Val Ile Gln Gln Ala Met 
        115                 120                 125


Pro Ser Pro Gln Ser Ser Ser Val Ile Thr Gln Ala Pro Ser Thr Asn 
    130                 135                 140


Arg Gln Ile Gly Pro Val Pro Gly Ser Leu Ser Ser Leu Leu His Leu 
145                 150                 155                 160


His Asn Arg Gln Arg Gln Pro Met Pro Ala Ser Met Pro Gly Thr Leu 
                165                 170                 175


Pro Asn Pro Thr Met Pro Gly Ser Ser Ala Val Leu Met Pro Met Glu 
            180                 185                 190


Arg Gln Met Ser Val Asn Ser Ser Ile Met Gly Met Gln Gly Pro Asn 
        195                 200                 205


Leu Ser Asn Pro Cys Ala Ser Pro Gln Val Gln Pro Met His Ser Glu 
    210                 215                 220


Ala Lys Met Arg Leu Lys Ala Ala Leu Thr His His Pro Ala Ala Met 
225                 230                 235                 240


Ser Asn Gly Asn Met Asn Thr Met Gly His Met Met Glu Met Met Gly 
                245                 250                 255


Ser Arg Gln Asp Gln Thr Pro His His His Met His Ser His Pro His 
            260                 265                 270


Gln His Gln Thr Leu Pro Pro His His Pro Tyr Pro His Gln His Gln 
        275                 280                 285


His Pro Ala His His Pro His Pro Gln Pro His His Gln Gln Asn His 
    290                 295                 300


Pro His His His Ser His Ser His Leu His Ala His Pro Ala His His 
305                 310                 315                 320


Gln Thr Ser Pro His Pro Pro Leu His Thr Gly Asn Gln Ala Gln Val 
                325                 330                 335


Ser Pro Ala Thr Gln Gln Met Gln Pro Thr Gln Thr Ile Gln Pro Pro 
            340                 345                 350


Gln Pro Thr Gly Gly Arg Arg Arg Arg Val Val Asp Glu Asp Pro Asp 
        355                 360                 365


Glu Arg Arg Arg Lys Phe Leu Glu Arg Asn Arg Ala Ala Ala Thr Arg 
    370                 375                 380


Cys Arg Gln Lys Arg Lys Val Trp Val Met Ser Leu Glu Lys Lys Ala 
385                 390                 395                 400


Glu Glu Leu Thr Gln Thr Asn Met Gln Leu Gln Asn Glu Val Ser Met 
                405                 410                 415


Leu Lys Asn Glu Val Ala Gln Leu Lys Gln Leu Leu Leu Thr His Lys 
            420                 425                 430


Asp Cys Pro Ile Thr Ala Met Gln Lys Glu Ser Gln Gly Tyr Leu Ser 
        435                 440                 445


Pro Glu Ser Ser Pro Pro Ala Ser Pro Val Pro Ala Cys Ser Gln Gln 
    450                 455                 460


Gln Val Ile Gln His Asn Thr Ile Thr Thr Ser Ser Ser Val Ser Glu 
465                 470                 475                 480


Val Val Gly Ser Ser Thr Leu Ser Gln Leu Thr Thr His Arg Thr Asp 
                485                 490                 495


Leu Asn Pro Ile Leu 
            500


<210>  3614
<211>  7896
<212>  DNA
<213>  Homo sapiens

<400>  3614
agagagcaag tgagcgagag cccagccgga gggagagcca gagctaggcg caaaagaagg     60

gccagcacat tacatcatcg cttggcctgg aatcaaatgg gaaggatatg actcactcaa    120

gctagttaag ctttggctca aattctacac acactcattc cagagctctc atgttctgca    180

cctcaggagg gaattcagcc tcagtgatgt ccatgaggcc tgtcccaggc tctctatctt    240

ctctgctaca tctccacaac agacagagac agcccatgcc agcctccatg cctgggaccc    300

tgcccaaccc tacaatgcca ggatcttccg ccgtcttgat gccaatggag cgacaaatgt    360

cagtgaactc cagcatcatg gggatgcaag gtccaaatct cagcaacccc tgtgcttctc    420

cccaggtcca gccaatgcat tcagaagcca aaatgaggtt gaaggctgca ttgactcacc    480

accctgctgc catgtcaaat gggaacatga acaccatggg acacatgatg gagatgatgg    540

gctcccggca ggaccagacg ccacaccatc acatgcactc gcacccgcat cagcaccaga    600

cactgccacc ccatcaccct tacccacacc agcaccagca cccagcacac catcctcacc    660

ctcaacccca tcaccagcag aaccatccac atcaccactc ccattcccac cttcatgcac    720

acccagcaca tcaccagacc tcgccacatc cgcccctgca caccggcaac caagcacagg    780

tttcaccagc aacacaacag atgcagccaa cccagacaat acagccaccc cagcccacag    840

gggggcgccg gcgaagggtg gtagacgagg atccggacga gaggcggcgg aaatttctgg    900

aacggaaccg ggcagctgcc acccgctgca gacagaagag gaaggtctgg gtgatgtcat    960

tggaaaagaa agcagaagaa ctcacccaga caaacatgca gcttcagaat gaagtgtcta   1020

tgttgaaaaa tgaggtggcc cagctgaaac agttgttgtt aacacataaa gactgcccaa   1080

taacagccat gcagaaagaa tcacaaggat atctaagtcc agagagtagc cctcctgcta   1140

gtcctgtccc agcttgctcc cagcaacaag tcatccagca taataccatc actacttcct   1200

catcggtcag cgaggtggta ggaagctcca ccctcagcca gctcaccact cacagaacag   1260

acctgaatcc gattctttaa aatgcaccat cagacctggc ctccaagaag agctgtagcg   1320

taccatgcgt cctttctttt aagggcattt ttagaattaa ctcagacctg gaagactcct   1380

cagttcttca aagactggct ttcattttta tagttattat ggaaatgttg tcttttatac   1440

ttagttatat aagaaaaaag ggagttatgc aattaatatc tatcagcttg ggaaacgctt   1500

tggtgctttt ctccagtttt ctggtaccag ttacttgttt ataaactgaa ccttttctgt   1560

atatagccat ggtttcattc ttatcagtcc aaccctttgc ctgaaacatt gaatcttgtt   1620

aaaccacagc ttttagctaa aatgaggtat acctagatgt caagtaagac agatccaagg   1680

taactgggta ggaaatcttt tgacatctta actcatgttg agtttgtgct gtggtgtcac   1740

cagaattcca gataaacaca cagcctttcc catacctttt tttttcttac tataaaatat   1800

tataagatcc attgatgtcc aaataatacc accaagcatc tcttcacctc tcctcctctt   1860

ggtccacttg ctaatgccca gttttcttct ccatttccac tttttcttag gctccctatt   1920

tactattcat tttgacttcc ttctgtttta tttttttccc tttagcattg catgtgaata   1980

agaaaataat gtttaaagaa aaaaaaaaaa aagcaaacct ccaaaacgtg gacctaacca   2040

ttgcttcact tacacttcac ccacagctgg agttcattca actcttgctt ttcacaaaat   2100

agtaaccagg agatgtttaa tgtgcctgat ttaatgtttt taataatcac agcaaatgaa   2160

aggtggttta gttataagtg aagcatggtt gaataccagc tggggagaca ctagggaagg   2220

gagctttgta agccttgatt gcgaaagtcc aaattttgat gtggggctat aacatgacac   2280

ccttggattg cgactggttt tatacggcct gcctataacg ttgaaaatcc atgtactaca   2340

taataattca gaagggctct attcactaca cagattacat tgttcaatca tcagctgcta   2400

atagcctaag atttattttt ttttttttct taagcctatg gaaccggctt tgctgttctg   2460

gggggtgaaa atagactaac tactggagaa acaaagagag aaagaaaacc cagtgtttcc   2520

ataggggcac ttttagcctt cccacaacag ttaagcactc tttgactgct gaaggaaccc   2580

catggatgag gtgcaggcta cttcactctt tttttttctt ttttgagaca gagtctcacc   2640

tattgcccag actgaagtgc agtggtgcga tcatggatca ctgcagcagc atcctccgag   2700

ttcaagctat ccttccacct ccgcctcctg agtagctggg accacaggtt cacataacca   2760

tgcctggcta atttattttt acttttattt taaaataaaa gatgaggtct gtcttatgtt   2820

gcccaggctg gtctcaaact atcctacttc ttcctcccaa agtgttggga ttataggtgt   2880

gagccactgc acccagccta cttcactctt ctgaattatt ctgatttatt ttcaacaact   2940

tttgtgaact tgcccgtgat acaaagcaga tagtccctga accacagtcg tgcctccttg   3000

aaacaagcca ttctactgtg ctaatgtttt aatatcacat ctcacaaata acaggggtga   3060

atgtttctct ctagcaatct aggcaggtgc tggtgtttca tctccatttg aatgcttgac   3120

ctcttaatgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt tcatgggttt taaaagaaca   3180

gtattttaca aaaggtgtag cttttataag agtgcagaaa agggaaggat gtgttttttt   3240

ctctcactat agtataagaa tctattttgg agaaaaaaag aaaatatgag ggtctcgaag   3300

catgattttt atataactag tttcagtttt atctaataac ttacttttta aatcaatatt   3360

tatcaacaat ctttccttgt atgcagtgct ttcaaaagat ggttttgagt gtccagtgaa   3420

acttatgact tggatatatg gttgaagaat caaaacaaaa gcaaaaaaaa aaagcaaaaa   3480

aagaaaagag aaaaaaagaa aaaatgcaaa tggaataatt ttctattata ttttagacaa   3540

acatatcatt ttcgagtatt ttaaatactg aattcatagt tgttgttttt taaattccaa   3600

cagtaacagc tgaatggttt aatctgactg gcttcctaag aaatgtttaa gactcagctt   3660

taaaaagaag ttaacattca tatctctgtt ttgaaatcaa aaatcatatt tcaaaattct   3720

ttcctaggac catctatgtg tctcccctcc cctccacaaa aaggagaaag agtgcattaa   3780

aatgtttagt tgggtttttt aatttttaat ttttatgtta tgttttgctt tgttttaagt   3840

aaacaaaaat ttttctttct ttactgcatg catagcactt aataaaatgg atttttaaaa   3900

aatccactag taatatcaga atgtccaggg agtgactgtc actacaatga tggtttagtt   3960

tacttctgtt ccaccttttg attgaaatat ttagttgtta ggctgaaagc ctcggcagtt   4020

aagaacttgc ctgagttttc ttcgttcagc aacttgacag tttgactgat gtgcattata   4080

tatagctcaa ttatgtctgt tttttatgct aagtaggaaa accaaccaca cacattagca   4140

aaccggcctc aacatataat tagaataaac tgtcttcttg ttctactcag ggcctttagg   4200

tgtgttcatt cacggtatgg aaatacagta aatgaaagat tccaactagt tgtcagtgct   4260

tcttgaaatt ccaaacagaa agatacattg gtcaaatcca acacttggct tatcaatatt   4320

aagtctttta cctaaaggcc cagccgtcac cagacaacag aataatcaat ctgcctgaaa   4380

atccctcctc cttgtcctac actttttgcc tgtttgggag aatatctttg tactccattc   4440

tcctccctca gccagttact gggtcaccca tccatgtgtt catgaatcaa tcatcacggc   4500

ctgcagagca cctgtcctaa ggagggaaaa tcctgtcaca ctgcctctcc ccattcgtgt   4560

gtggttttct tgatcggtga gatctgtctc tgaagtcact gccagcctcc ctgggaacgt   4620

ctatagtgcc tcccctgcct tatgtgatgg gagttaacaa ctcagataag tacacctgag   4680

agcatttcta tcaggtaaac tgtcacttaa atggaggtgt ccacatctta attgtttctc   4740

cttgacacat ttctcaatcc acgaagccag gagaggtaga gtgaaaatcc cagccatgga   4800

tgaatgtact aatttgaaag ccaagtgtta agtcggatgt tttcccgtta cactactact   4860

cagccctctc ctgcggccac atcaacggat gcaagtcaca gtcttaacac agcctgtggg   4920

agacaagcag tttgtgtgct cacagtatat attatagtaa ttagggtgac ttagagcaaa   4980

tactcttcag atcctatgta gtcagtgaaa caaaatggag agcgtattct gatagaagga   5040

cgtcgacggt gaatgttctg gtggttgttg cctgttaagt aaactttagt gtgtaagttg   5100

agtttgtcat taaaatcata aaccagctgc ggtaacagac aagcctttgg ctggggagtt   5160

ttaagcctcg gtaactgcta taaaactagc catccagtta ggatagaatg tgtttctttc   5220

tggttaaaaa aaggaaaaac catctaagaa aatatatatg tatgtatgtg tgtatacagt   5280

ggaattcaaa ggaccaaagc aaaatttgaa caggaatcta ttaatttaga attttataag   5340

atatttatta ataaatgtta tttttaaaca ttccatttga acagtattct gtaggatcta   5400

cttgttttta aagtgttagt ccataataaa ctactatagt tatgtgtatt ttcatttttc   5460

agggtttcaa atggctattc tccatcattt ggtggaaatg tttgcttaga tctctgtgca   5520

tagacatttc aaggattttt attgctctgt gagttatttt ttaatcaaca ttctgaacag   5580

ttttttttaa acatttattt ctgtgtgttc atttttaaag taagctcttt catttaggaa   5640

gcagagttca gctaaaggga atcagtaact ctaactggaa cagctttctt gtagaagtgt   5700

aaaaacagct tcatctctgc ctctctccac cccaccccaa tttcctagaa agccttgcac   5760

tattcagctc ccttagtgct ttttgtccct tcccgaacaa tatgcagtag ctttaagcca   5820

ttcaagctcc attatgcagt atatctgaga agggaaagga aacaacccat ttaaatttga   5880

ataaaaccgt gcctatgcga acagtagcaa tttagaatct cttttctgct tttaaaataa   5940

tttatattta aaaattgcac tttagctttt tgatcccttt gtatttctct tattctcttt   6000

ctaacctctt ctctgtcctc aaacttgcct ttgctctcct ttacaatacc ccccacccct   6060

cctccaaggc tctgagcggc atcatttaaa atactttaca gatatttgca ccaggtacat   6120

ttatgtgcgt ccattggtag cacagctgag acctgtgtct cacatcagcc taggtgaagc   6180

ctactacaag aatgccaagg agaagagcca gtacactata tggtttatac tctttatccc   6240

tttattcata gcatgttttt taaaaatgtt atattatgca acagatgtga ggcagcagct   6300

aagctatact taagaatttt ctctcacctt ccaaaccaaa gtgtcctgaa taagccagga   6360

gacttattct tttgtgcacc ctggtgcaca tctgactgtt gtcctagcca tagactctct   6420

gaggccactg aaagaacagt ggccctatcg atttcattcc taggtctcaa aaatacaatg   6480

ttgccttgta acataattag ggacagcacc tctatttcac aattataatc taaggtagga   6540

taagacgaca cagcagcaat aaacttacaa gtaaaattca ataccaaaac aaacacaaag   6600

aaatttaaaa aacaaaaaac ctagctcatc atgttgtgaa aatgaaaaag tgaatgtcca   6660

ttcaaaatat tttactattt cttgtggagt ttttcagtga tgtaatgctt gtagccaaat   6720

tgcttaaaga gtgtttatat atttttttcc ttataaattg tctatttttt aaaaaagcta   6780

tttaaccaca gctgaagtgg ggggtaaggc caaattgcca acacttgtta aaagattaat   6840

actcttaagt ggcactctga tacctttcca acttgtcatc agaaaggaat caataattac   6900

caactgttgt atttagacca acttacaata tctagctcat tagaagccag gatctagaaa   6960

gctccttcta agccatttaa gatattctta cattgagctt catattatag aactttatag   7020

gattggatat tttacaatag aataatttag cctcaggact gagaatgtgg aagctgaata   7080

aattagcttt aaatacatca ttaaaatctt atgcacaata agctcattag attctagttt   7140

tctcctttag aataccaatg ccacagacac tacaggagat aatgaaaggt atcagttgtg   7200

ttgagtggag ggagtttaag agaaaggacc cttcccaacc agcagccagt agaaaataca   7260

acctactcac ctttttccct tctaagttct gctaaatcac atctgcctca tagagaaagg   7320

aatgttgcct ttgagaactg tcttggagaa cagataagct tgaaatgttc tctctagaga   7380

ggacataggg tttgggatcc tctgaaaagg cccagaaaaa tagctcagtt caaatacaat   7440

gttctaggac aattggaata taaatattgt ccaaaaatat aattaaaaga aaaaagttta   7500

gcactgtgta aagtaagtgt taactgagga agtcccaaaa aggtgctgtc actttaagtt   7560

ctggacttgg ggttctttgt atttgtaaac agcaaagcat ttgtgtttgt ttgtctattt   7620

gtaaagcaac caccttcctt attggaagga gaaaaaaagg ggtacataca tgtaaatact   7680

tgctgcagca tttaatatgt ttaattttgt gttaagcttt ttgttgcatc gtgaacacat   7740

ttattgttac caatggacaa tgagttcatt aagactgttc aactaggtca gatttttaca   7800

tctctttcta gcaagaagag acaagatttt gtgcatttgt acaaatgtta atatcactgc   7860

aattccaata taataaagca ctcaaatgca aataat                             7896


<210>  3615
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  3615

Met Phe Cys Thr Ser Gly Gly Asn Ser Ala Ser Val Met Ser Met Arg 
1               5                   10                  15


Pro Val Pro Gly Ser Leu Ser Ser Leu Leu His Leu His Asn Arg Gln 
            20                  25                  30


Arg Gln Pro Met Pro Ala Ser Met Pro Gly Thr Leu Pro Asn Pro Thr 
        35                  40                  45


Met Pro Gly Ser Ser Ala Val Leu Met Pro Met Glu Arg Gln Met Ser 
    50                  55                  60


Val Asn Ser Ser Ile Met Gly Met Gln Gly Pro Asn Leu Ser Asn Pro 
65                  70                  75                  80


Cys Ala Ser Pro Gln Val Gln Pro Met His Ser Glu Ala Lys Met Arg 
                85                  90                  95


Leu Lys Ala Ala Leu Thr His His Pro Ala Ala Met Ser Asn Gly Asn 
            100                 105                 110


Met Asn Thr Met Gly His Met Met Glu Met Met Gly Ser Arg Gln Asp 
        115                 120                 125


Gln Thr Pro His His His Met His Ser His Pro His Gln His Gln Thr 
    130                 135                 140


Leu Pro Pro His His Pro Tyr Pro His Gln His Gln His Pro Ala His 
145                 150                 155                 160


His Pro His Pro Gln Pro His His Gln Gln Asn His Pro His His His 
                165                 170                 175


Ser His Ser His Leu His Ala His Pro Ala His His Gln Thr Ser Pro 
            180                 185                 190


His Pro Pro Leu His Thr Gly Asn Gln Ala Gln Val Ser Pro Ala Thr 
        195                 200                 205


Gln Gln Met Gln Pro Thr Gln Thr Ile Gln Pro Pro Gln Pro Thr Gly 
    210                 215                 220


Gly Arg Arg Arg Arg Val Val Asp Glu Asp Pro Asp Glu Arg Arg Arg 
225                 230                 235                 240


Lys Phe Leu Glu Arg Asn Arg Ala Ala Ala Thr Arg Cys Arg Gln Lys 
                245                 250                 255


Arg Lys Val Trp Val Met Ser Leu Glu Lys Lys Ala Glu Glu Leu Thr 
            260                 265                 270


Gln Thr Asn Met Gln Leu Gln Asn Glu Val Ser Met Leu Lys Asn Glu 
        275                 280                 285


Val Ala Gln Leu Lys Gln Leu Leu Leu Thr His Lys Asp Cys Pro Ile 
    290                 295                 300


Thr Ala Met Gln Lys Glu Ser Gln Gly Tyr Leu Ser Pro Glu Ser Ser 
305                 310                 315                 320


Pro Pro Ala Ser Pro Val Pro Ala Cys Ser Gln Gln Gln Val Ile Gln 
                325                 330                 335


His Asn Thr Ile Thr Thr Ser Ser Ser Val Ser Glu Val Val Gly Ser 
            340                 345                 350


Ser Thr Leu Ser Gln Leu Thr Thr His Arg Thr Asp Leu Asn Pro Ile 
        355                 360                 365


Leu 



<210>  3616
<211>  643
<212>  DNA
<213>  Homo sapiens

<400>  3616
attccagagc tctcatgttc tgcacctcag gagggaattc agcctcagtg atgtccatga     60

ggcctgtccc aggctctcta tcttctctgc tacatctcca caacagacag agacagccca    120

tgccagcctc catgcctggg accctgccca accctacaat gccaggatct tccgccgtct    180

tgatgccaat ggagcgacaa atgtcagtga actccagcat catggggatg caaggtccaa    240

atctcagcaa cccctgtgct tctccccagg tccagccaat gcattcagaa gccaaaatgg    300

taagtaacag ttataatcac cctttcatta ttctgtgact ttttcttttg aattttactc    360

tgactccaaa accttagttc agctaggtag agggctccat ctttgttttg gtgaatgaaa    420

ggcagtgcag agactgcctc tctttttgag gatgtttgtt acagagcctt ggtgtcagat    480

aatcatgtaa caagcactgg attggcaagt ggtattaatg aaaggaacat ttaggagttt    540

tggtagatcc atacaagttg gggtaggata tacccaagcg tgtatatatt tgctcagcat    600

gtgaaataat aaaaataata caaaactact cattcttcaa ggt                      643


<210>  3617
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  3617

Met Phe Cys Thr Ser Gly Gly Asn Ser Ala Ser Val Met Ser Met Arg 
1               5                   10                  15


Pro Val Pro Gly Ser Leu Ser Ser Leu Leu His Leu His Asn Arg Gln 
            20                  25                  30


Arg Gln Pro Met Pro Ala Ser Met Pro Gly Thr Leu Pro Asn Pro Thr 
        35                  40                  45


Met Pro Gly Ser Ser Ala Val Leu Met Pro Met Glu Arg Gln Met Ser 
    50                  55                  60


Val Asn Ser Ser Ile Met Gly Met Gln Gly Pro Asn Leu Ser Asn Pro 
65                  70                  75                  80


Cys Ala Ser Pro Gln Val Gln Pro Met His Ser Glu Ala Lys Met Val 
                85                  90                  95


Ser Asn Ser Tyr Asn His Pro Phe Ile Ile Leu 
            100                 105


<210>  3618
<211>  583
<212>  DNA
<213>  Homo sapiens

<400>  3618
attccagagc tctcatgttc tgcacctcag gagggaattc agcctcagtg atgtccatga     60

ggcctgtccc aggctctcta tcttctctgc tacatctcca caacagacag agacagccca    120

tgccagcctc catgcctggg accctgccca accctacaat gccaggatct tccgccgtct    180

tgatgccaat ggagcgacaa atgtcagtga actccagcat catggggatg caaggtccaa    240

atctcagcaa cccctgtgct tctccccagg tccagccaat gcattcagaa gccaaaatgt    300

tgttgtgaaa tacccgccat gccaagacag agttcttcct tctggatgca tttgcaatct    360

tacaaagagc ttctggtgac tcagaaaatc ccatgcgtcc attttccaaa ttggatgtta    420

tgtgattaaa aataaatgta aatcacacag agactttggt gtgcttccga aaattcccat    480

gtcaggagtt ggcatgtatc aaccatgtgt aggtgtgtgt gtgctcacta atactgtgtg    540

agcatttagg accttatttg agaagttctt tcctggaaga aga                      583


<210>  3619
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  3619

Met Phe Cys Thr Ser Gly Gly Asn Ser Ala Ser Val Met Ser Met Arg 
1               5                   10                  15


Pro Val Pro Gly Ser Leu Ser Ser Leu Leu His Leu His Asn Arg Gln 
            20                  25                  30


Arg Gln Pro Met Pro Ala Ser Met Pro Gly Thr Leu Pro Asn Pro Thr 
        35                  40                  45


Met Pro Gly Ser Ser Ala Val Leu Met Pro Met Glu Arg Gln Met Ser 
    50                  55                  60


Val Asn Ser Ser Ile Met Gly Met Gln Gly Pro Asn Leu Ser Asn Pro 
65                  70                  75                  80


Cys Ala Ser Pro Gln Val Gln Pro Met His Ser Glu Ala Lys Met Leu 
                85                  90                  95


Leu 



<210>  3620
<211>  2913
<212>  DNA
<213>  Homo sapiens

<400>  3620
gagcctttgc aaatgcatgc agagcatgga aatgacccag ctgccctgct gttgaaacag     60

aatcctattt ggaaggcaga catgtggccc atctctgtag ccatcactga gaaatctgga    120

ttttcaaggg cctttctctc tgttgcccag gctggagttt agcgactcaa tcatggctca    180

ctgactgcag catcgacctc cggggctcaa gtgatccttt catctcagcc tcctcagtag    240

ctgagactac aggctcctcc agatctgcct cctgctgacc ttgtacccag ctgcagcgac    300

accgagctcc tcacagcttc ccaaagtggg ctggcccctc tcacgacagg gtcatcgcac    360

aggctccctc tgtgggggaa cacaacggga gtcatttcaa caccactttc ttcaggaagc    420

ctattctgat ccttggtact ccaagcagct gttgtcaatg cctaccccag gctgctagga    480

aatgctttcc actcggaact gagacctaaa actggaaact aggctgcagg accacctggg    540

tacgtgtgaa ttacagaggt tcatgcattt ccaaatgggg gtgtcatttt agaactgggg    600

cgtaagatga tgagcaacag aaaagacaac gccgagcccc cgggtatgag ctcagaactc    660

tttacatgtt tgatgctcca aatggtctag ggcagggggg cttcagagcc ttggcagcag    720

aacgtggtcg cgtagatgtt tatctgattt tctgttgcgc tgctgctcaa ccgccactac    780

ggaagtgcac actgccacct tatggacgtc ttgagaagtt acacttacac gttattaatt    840

atattaaata aaattcaaat gtaataaata atgtcagggg tagtttttat aaacatttgc    900

aatgaaaatt catatgagga cttcagacag aatatattca aatgaagagt tgatttcgat    960

ttcactgatg aaattaaata acaggattaa gatgaaattc tcagctattt tagcatttta   1020

gtgtttttct gctactgagt tgtgggaatt ccttatatgt ttcggcttgt cataaatatg   1080

gttgacaaat attttatctg attttatacg ttttttcact ctattgatta tttccttggt   1140

tgtacagaaa ctttttaatt ttatgtagtc ccacttgtct attttttact tttgttgact   1200

gtgcttttgg tgttgtattc aagaaatcac tgccaagatc attatcatga agctttctcc   1260

ctatgatttc ttctagaagt tttatagttg gggtattaca tttatttatt tatttaaaga   1320

caagatattg ttctgtcact cagctgcagt gcagtggcac aatcaaagct cactgcagcc   1380

ccaacctcct gggctcaagt gatcctccca tctcagcctc ccaagtaact gcaggtaact   1440

acaagtgtgc actaccacac caggctattt tttgtggaga cagggtttct ctgtgtttcc   1500

tgggctgatt tcgaactctt gaactcaagt gatccttcca ccttgccctc ctaaagtgct   1560

gggattacag gtgtgagcct ccaaccctgg ccaggtctta catgtaagtc attaatctat   1620

tttgagttga atgttgtgtg tggtgtaata tacacatgtg aatatccagt tttcctaaca   1680

tttgttgaag aaactactgt gtattcttag catctttgtc aaagatcaat taatcatatg   1740

tgtgtgtgtt tatttctgca ctctccattc tattccattg atttatgtgt ttatctttaa   1800

gccaatacaa tacagtttta attgcagtag ctttgtaata tattttgaaa tcaggaacta   1860

tgatgcctcc agctttcttt ttttttctag agattgtttt ggttcttctg gatcttttat   1920

agtttaatat gaatcttagg attgttttta ctatgtccgt aaaaaatgcc attgggattt   1980

tgatagaaat tgcatttaaa ctgcagatca ctttgaagaa tatgattatt tcaacaatat   2040

taagtcttcc aatccatgaa catgggattt tgtgaatatt cttgtatggt tttagcctaa   2100

ttagaatgtt tctaatgttt tgattttaca tacaatgtta gctgtaagtt tcagacggaa   2160

ttatttctca actcttagtt tgttcagagc tttctaaaat tattattaat gaaagttaat   2220

catttttggc atagacttgg tttttaactt tgattaagtc cagttattac ttttaaaatt   2280

ttatgatgac tctttgtgtt ctaagaaata tttgattacc atcccaagat tgtaaaaata   2340

ttctatactt ttggaaaagc tttatagttg taaactttta tgtgtaagtc tgtgatccat   2400

ctgaactaca ttgcatattt tatgaaggtg aaggttcatt attttccata tggagtttaa   2460

atttttccag catcatttat ttgaaagaat ttcctttccc tgttgaacta ccttgatgtc   2520

tttggagaaa ataaattgac agtatgtgtg ggactctttc tgaactctgt atttttttca   2580

ttgatctata catggcatta ccacaccatt ttaattgctg tagtttaata gtaaagtgca   2640

cgttttctac cttttttctt tctgactctt ctgggtactt gacatttcca aatcaatttt   2700

agaatcagat tgtcaagtgc aacaaaaaat ggttgggatt tttattatga ttgcattgaa   2760

tctatagaat aatttcgatt aaaagtgaca tcttgggccg ggtgcagtgg ctcgcacctg   2820

taatcccagc acttcgggag gccaaggtgg gcagatcaca aggtcaagag ttcaagacca   2880

gcctggccaa catagtgaaa ccccaccact gct                                2913


<210>  3621
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  3621

Met His Ala Glu His Gly Asn Asp Pro Ala Ala Leu Leu Leu Lys Gln 
1               5                   10                  15


Asn Pro Ile Trp Lys Ala Asp Met Trp Pro Ile Ser Val Ala Ile Thr 
            20                  25                  30


Glu Lys Ser Gly Phe Ser Arg Ala Phe Leu Ser Val Ala Gln Ala Gly 
        35                  40                  45


Val 



<210>  3622
<211>  529
<212>  DNA
<213>  Homo sapiens

<400>  3622
gctgttgaaa cagaatccta tttggaaggc agacatgtgg cccatctctg tagccatcac     60

tgagaaatct ggattttcaa gggcctttct ctctgttgcc caggctggag tttagcgact    120

caatcatggc tcactgactg cagcatcgac ctccggggct caagtgatcc tttcatctca    180

gcctcctcag tagctgagac tacagatccc tagaagactg tggccagcag gtattagcgt    240

caggagataa acagaactga gagcgtttgt cactagaaga cttacattac aagtaatcct    300

atagtgttct gcagactgaa gagcgatgaa acgagatggc aattctgatg cctagaagaa    360

atgaagacaa ccaaaaatga tggtaagtat gtgagttagt aagttaagaa ctcttctctc    420

tctctctctc tctccctccc ctcaccacat atgtgtgtat ctgtattttc taaaaaacat    480

gacattttaa caaaaattat agcactttat tgatgagttt acaagatat                529


<210>  3623
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  3623

Glu Ile Trp Ile Phe Lys Gly Leu Ser Leu Cys Cys Pro Gly Trp Ser 
1               5                   10                  15


Leu Ala Thr Gln Ser Trp Leu Thr Asp Cys Ser Ile Asp Leu Arg Gly 
            20                  25                  30


Ser Ser Asp Pro Phe Ile Ser Ala Ser Ser Val Ala Glu Thr Thr Asp 
        35                  40                  45


Pro 



<210>  3624
<211>  750
<212>  DNA
<213>  Homo sapiens

<400>  3624
agggcctttc tctctgttgc ccaggctgga gtttagcgac tcaatcatgg ctcactgact     60

gcagcatcga cctccggggc tcaagtgatc ctttcatctc agcctcctca gtagctgaga    120

ctacagataa acagaactga gagcgtttgt cactagaaga cttacattac aagtaatcct    180

atagtgttct gcagactgaa gagcgatgaa acgagatggc aattctgatg cctagaagaa    240

atgaagacaa ccaaaaatga tgtagataaa tggcaagcaa aaaacgagaa gtccagttac    300

aggcagaagc tgacaacatt gtgactttgc agccatttag agataaatgt gaacctgttt    360

ttctctttag tgttatgatg ttttgcgtat tattaaagat gaagacttca aaatactgga    420

gcaaagacaa gtagtattat cggaaaaaga agcacaagca ctgtgcaagg aatatgaaaa    480

tgaagactat tttaataaac ttatagaaaa catgaccagt ggtccatctc tagcccttgt    540

tttattgaga gacaatggct tgcaatactg gaaacaatta ctgggaccaa gaactgttga    600

agaagccatt gaatattttc cagagagttt atgtgcacag tttgcgatgg acagtttgcc    660

ggtcaaccag ttgtatggca gcgattcatt agaaaccgct gaaagggaaa tacagcattt    720

ctttcctctt caaagcactt taggcttgat                                     750


<210>  3625
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  3625

Met Thr Ser Gly Pro Ser Leu Ala Leu Val Leu Leu Arg Asp Asn Gly 
1               5                   10                  15


Leu Gln Tyr Trp Lys Gln Leu Leu Gly Pro Arg Thr Val Glu Glu Ala 
            20                  25                  30


Ile Glu Tyr Phe Pro Glu Ser Leu Cys Ala Gln Phe Ala Met Asp Ser 
        35                  40                  45


Leu Pro Val Asn Gln Leu Tyr Gly Ser Asp Ser Leu Glu Thr Ala Glu 
    50                  55                  60


Arg Glu Ile Gln His Phe Phe Pro Leu Gln Ser Thr Leu Gly 
65                  70                  75


<210>  3626
<211>  3426
<212>  DNA
<213>  Homo sapiens

<400>  3626
cagtcccgac gcatcccgcc cccgctctgt cgctttaagc tggtcccgcc gccgcgcccc     60

gccctcaccc ctccgcgctc cgcggctccc cgccgcttct cccgctcctc ccttgctcgg    120

ccctctcctc ctcctcccgc tcctcctccc gctcctccgc gccgccgcca gccccgctgc    180

gcgctctgct cttcgcagct ccccggaccc gcagccatgg ccgacatcaa gacgggcatc    240

ttcgccaaga acgtccagaa gcgactcaac cgcgcgcagg aaaaggtcct ccaaaagctg    300

gggaaagctg atgagacaaa agacgaacag ttcgaagaat atgtccagaa cttcaaacgg    360

caagaagcag agggtaccag acttcagcga gaactccgag gatatttagc agcaatcaaa    420

ggcatgcagg aggcctccat gaagctcaca gagtcgctgc atgaagtcta tgagcctgac    480

tggtatgggc gggaagatgt gaaaatggtt ggtgagaaat gtgatgtgct gtgggaagac    540

ttccatcaaa aactcgtgga tgggtccttg ctaacactgg atacctacct ggggcaattt    600

cctgacataa agaatcgcat cgccaagcgc agcaggaagc tagtggacta tgacagtgcc    660

cgccaccatc tggaagctct gcagagctcc aagaggaagg atgagagtcg aatctctaag    720

gcagaagaag aatttcagaa agcacagaaa gtgtttgaag agtttaacgt tgacttacaa    780

gaagagttac catcattatg gtcaagacga gttggatttt atgttaatac tttcaaaaac    840

gtctccagcc ttgaagccaa gtttcataag gaaattgcgg tgctttgcca caaactgtat    900

gaagtgatga caaaactggg tgaccagcac gccgacaagg ccttcaccat ccaaggagcg    960

cccagtgatt cgggtcctct ccgcattgca aagacaccat caccgcctga ggagccttca   1020

cccctcccga gcccgacagc aagtccaaat catacattag cacctgcgtc tcccgcacca   1080

gcacggcctc ggtcaccttc acagacaagg aaagggcctc ctgtcccacc tctacctaaa   1140

gtcaccccga caaaggaact gcagcaggag aacatcatca gtttctttga ggacaacttt   1200

gttccagaaa tcagtgtgac aacaccttcc cagaatgaag tccctgaggt gaagaaagag   1260

gagactttgc tggatctgga ctttgatcct ttcaagcccg aggtgacacc tgcaggttct   1320

gctggagtga cccactcacc catgtctcag acattgccct gggacctatg gacgacaagc   1380

actgatttgg tacagccggc ttctggtggt tcatttaatg gattcacaca gccccaggat   1440

acttcattat tcacaatgca gacagaccag agtatgatct gcaacttggc tgaatctgaa   1500

caggctccac ccacagagcc aaaagcagag gagcctctgg ctgctgtcac acctgccgtt   1560

ggtctggacc ttggaatgga cactcgggct gaggagccag tggaggaggc agtgatcata   1620

cctggagctg atgctgatgc agctgttgga accttggtgt cagcagctga gggggcccca   1680

ggagaggaag cagaggcgga gaaggccact gtccctgccg gggaaggagt aagtttagag   1740

gaggccaaaa ttggaactga aaccactgag ggtgcagaga gtgcccaacc tgaagcagag   1800

gagctcgaag caacagtgcc tcaggagaag gtcattcctt cggtggtcat agagcctgcc   1860

tccaaccatg aagaggaagg agaaaacgaa ataactatag gtgcagagcc caaggagacc   1920

accgaggacg cggctcctcc gggccccacc agcgagacac cggagctggc tacggagcag   1980

aagcctatcc aggaccctca gcccacgcct tctgcaccag ccatgggggc tgctgaccag   2040

ctagcatctg caagggaggc ctctcaggaa ttgcctcctg gctttctcta caaggtggaa   2100

acactgcatg attttgaggc agcaaattct gatgaactta ccttacaaag gggtgatgtg   2160

gtgctggtgg tcccctcaga ttcagaagct gatcaggatg caggctggct ggtgggagtg   2220

aaggaatcag actggcttca gtacagagac cttgccacct acaaaggcct ctttccagag   2280

aacttcaccc gacgcttaga ttagggcaac aagtactgca agaaggagct cagttacggg   2340

gtttttaaac cttcatgaaa acctgaagag ttcacttttg ttattatgct cttaatgatt   2400

tacagactga tgccagacaa accttgggaa gatgtatcaa tggagcatgt gtgcaaaaaa   2460

atgtaagagg aaaaaaagta aattaaggaa aaaatcctca ctcattccca tgttgtcaat   2520

aacaggtttg tttgtgcttt gtccaagctg tggagactct tgtacttgat cccctcccac   2580

caattctaaa gtagctttct ccagatcaga ctttaatttc tctgcatcag gtgtatcgta   2640

ttgagtggct gccctgcaga agatgtgatg aattatcctg tagtacaaga ttatcttatt   2700

cccctgccca ggtgtgagca cgtgctctcg ctccctttca ggtttactat gtttaaaact   2760

aaactgctgc aaaagttctc aatgttcttt tccaacacat ctatatatat atggacacac   2820

agtcacgcaa gctagttccc atgactcctg gatctatgtg tatgcagaag gctacatata   2880

catagttgct tctttccttt ccattgtagc tctttgcctc tcaattgtca ttgatacatg   2940

cattgctctt attctgtctg gcattacaat tgcagttttg cctaatggca aaaccagcca   3000

tcccattggc aaaagagtca acagtatctg tgtttgtact gtgcagtttt caggatgaga   3060

tgacagatag cacgactaca ctgaggcacc ctcagagaag gcagggcctg atttatctag   3120

ctgtccagcc gctgtggctg gaggtaggct agttgggatg ggcagctaag cagtcttctc   3180

ttctgccttt atgagattgg gtagaaagat ggggcatatt catctacccc caaaagaaca   3240

ctataaaaac agctcctcta tatttccacc tctttctatt tatgcaactc atcttcacag   3300

attgttctaa agtaaaatag atggtgtatg ctgtatccac aaatcatctg taacaattat   3360

gttttcagtg ctgtgtcatt ccaaataaac ctttggtaat cttcaacgat taccctaatt   3420

cctttt                                                              3426


<210>  3627
<211>  695
<212>  PRT
<213>  Homo sapiens

<400>  3627

Met Ala Asp Ile Lys Thr Gly Ile Phe Ala Lys Asn Val Gln Lys Arg 
1               5                   10                  15


Leu Asn Arg Ala Gln Glu Lys Val Leu Gln Lys Leu Gly Lys Ala Asp 
            20                  25                  30


Glu Thr Lys Asp Glu Gln Phe Glu Glu Tyr Val Gln Asn Phe Lys Arg 
        35                  40                  45


Gln Glu Ala Glu Gly Thr Arg Leu Gln Arg Glu Leu Arg Gly Tyr Leu 
    50                  55                  60


Ala Ala Ile Lys Gly Met Gln Glu Ala Ser Met Lys Leu Thr Glu Ser 
65                  70                  75                  80


Leu His Glu Val Tyr Glu Pro Asp Trp Tyr Gly Arg Glu Asp Val Lys 
                85                  90                  95


Met Val Gly Glu Lys Cys Asp Val Leu Trp Glu Asp Phe His Gln Lys 
            100                 105                 110


Leu Val Asp Gly Ser Leu Leu Thr Leu Asp Thr Tyr Leu Gly Gln Phe 
        115                 120                 125


Pro Asp Ile Lys Asn Arg Ile Ala Lys Arg Ser Arg Lys Leu Val Asp 
    130                 135                 140


Tyr Asp Ser Ala Arg His His Leu Glu Ala Leu Gln Ser Ser Lys Arg 
145                 150                 155                 160


Lys Asp Glu Ser Arg Ile Ser Lys Ala Glu Glu Glu Phe Gln Lys Ala 
                165                 170                 175


Gln Lys Val Phe Glu Glu Phe Asn Val Asp Leu Gln Glu Glu Leu Pro 
            180                 185                 190


Ser Leu Trp Ser Arg Arg Val Gly Phe Tyr Val Asn Thr Phe Lys Asn 
        195                 200                 205


Val Ser Ser Leu Glu Ala Lys Phe His Lys Glu Ile Ala Val Leu Cys 
    210                 215                 220


His Lys Leu Tyr Glu Val Met Thr Lys Leu Gly Asp Gln His Ala Asp 
225                 230                 235                 240


Lys Ala Phe Thr Ile Gln Gly Ala Pro Ser Asp Ser Gly Pro Leu Arg 
                245                 250                 255


Ile Ala Lys Thr Pro Ser Pro Pro Glu Glu Pro Ser Pro Leu Pro Ser 
            260                 265                 270


Pro Thr Ala Ser Pro Asn His Thr Leu Ala Pro Ala Ser Pro Ala Pro 
        275                 280                 285


Ala Arg Pro Arg Ser Pro Ser Gln Thr Arg Lys Gly Pro Pro Val Pro 
    290                 295                 300


Pro Leu Pro Lys Val Thr Pro Thr Lys Glu Leu Gln Gln Glu Asn Ile 
305                 310                 315                 320


Ile Ser Phe Phe Glu Asp Asn Phe Val Pro Glu Ile Ser Val Thr Thr 
                325                 330                 335


Pro Ser Gln Asn Glu Val Pro Glu Val Lys Lys Glu Glu Thr Leu Leu 
            340                 345                 350


Asp Leu Asp Phe Asp Pro Phe Lys Pro Glu Val Thr Pro Ala Gly Ser 
        355                 360                 365


Ala Gly Val Thr His Ser Pro Met Ser Gln Thr Leu Pro Trp Asp Leu 
    370                 375                 380


Trp Thr Thr Ser Thr Asp Leu Val Gln Pro Ala Ser Gly Gly Ser Phe 
385                 390                 395                 400


Asn Gly Phe Thr Gln Pro Gln Asp Thr Ser Leu Phe Thr Met Gln Thr 
                405                 410                 415


Asp Gln Ser Met Ile Cys Asn Leu Ala Glu Ser Glu Gln Ala Pro Pro 
            420                 425                 430


Thr Glu Pro Lys Ala Glu Glu Pro Leu Ala Ala Val Thr Pro Ala Val 
        435                 440                 445


Gly Leu Asp Leu Gly Met Asp Thr Arg Ala Glu Glu Pro Val Glu Glu 
    450                 455                 460


Ala Val Ile Ile Pro Gly Ala Asp Ala Asp Ala Ala Val Gly Thr Leu 
465                 470                 475                 480


Val Ser Ala Ala Glu Gly Ala Pro Gly Glu Glu Ala Glu Ala Glu Lys 
                485                 490                 495


Ala Thr Val Pro Ala Gly Glu Gly Val Ser Leu Glu Glu Ala Lys Ile 
            500                 505                 510


Gly Thr Glu Thr Thr Glu Gly Ala Glu Ser Ala Gln Pro Glu Ala Glu 
        515                 520                 525


Glu Leu Glu Ala Thr Val Pro Gln Glu Lys Val Ile Pro Ser Val Val 
    530                 535                 540


Ile Glu Pro Ala Ser Asn His Glu Glu Glu Gly Glu Asn Glu Ile Thr 
545                 550                 555                 560


Ile Gly Ala Glu Pro Lys Glu Thr Thr Glu Asp Ala Ala Pro Pro Gly 
                565                 570                 575


Pro Thr Ser Glu Thr Pro Glu Leu Ala Thr Glu Gln Lys Pro Ile Gln 
            580                 585                 590


Asp Pro Gln Pro Thr Pro Ser Ala Pro Ala Met Gly Ala Ala Asp Gln 
        595                 600                 605


Leu Ala Ser Ala Arg Glu Ala Ser Gln Glu Leu Pro Pro Gly Phe Leu 
    610                 615                 620


Tyr Lys Val Glu Thr Leu His Asp Phe Glu Ala Ala Asn Ser Asp Glu 
625                 630                 635                 640


Leu Thr Leu Gln Arg Gly Asp Val Val Leu Val Val Pro Ser Asp Ser 
                645                 650                 655


Glu Ala Asp Gln Asp Ala Gly Trp Leu Val Gly Val Lys Glu Ser Asp 
            660                 665                 670


Trp Leu Gln Tyr Arg Asp Leu Ala Thr Tyr Lys Gly Leu Phe Pro Glu 
        675                 680                 685


Asn Phe Thr Arg Arg Leu Asp 
    690                 695


<210>  3628
<211>  3300
<212>  DNA
<213>  Homo sapiens

<400>  3628
cagtcccgac gcatcccgcc cccgctctgt cgctttaagc tggtcccgcc gccgcgcccc     60

gccctcaccc ctccgcgctc cgcggctccc cgccgcttct cccgctcctc ccttgctcgg    120

ccctctcctc ctcctcccgc tcctcctccc gctcctccgc gccgccgcca gccccgctgc    180

gcgctctgct cttcgcagct ccccggaccc gcagccatgg ccgacatcaa gacgggcatc    240

ttcgccaaga acgtccagaa gcgactcaac cgcgcgcagg aaaaggtcct ccaaaagctg    300

gggaaagctg atgagacaaa agacgaacag ttcgaagaat atgtccagaa cttcaaacgg    360

caagaagcag agggtaccag acttcagcga gaactccgag gatatttagc agcaatcaaa    420

ggcatgcagg aggcctccat gaagctcaca gagtcgctgc atgaagtcta tgagcctgac    480

tggtatgggc gggaagatgt gaaaatggtt ggtgagaaat gtgatgtgct gtgggaagac    540

ttccatcaaa aactcgtgga tgggtccttg ctaacactgg atacctacct ggggcaattt    600

cctgacataa agaatcgcat cgccaagcgc agcaggaagc tagtggacta tgacagtgcc    660

cgccaccatc tggaagctct gcagagctcc aagaggaagg atgagagtcg aatctctaag    720

gcagaagaag aatttcagaa agcacagaaa gtgtttgaag agtttaacgt tgacttacaa    780

gaagagttac catcattatg gtcaagacga gttggatttt atgttaatac tttcaaaaac    840

gtctccagcc ttgaagccaa gtttcataag gaaattgcgg tgctttgcca caaactgtat    900

gaagtgatga caaaactggg tgaccagcac gccgacaagg ccttcaccat ccaaggagcg    960

cccagtgatt cgggtcctct ccgcattgca aagacaccat caccgcctga ggagccttca   1020

cccctcccga gcccgacagc aagtccaaat catacattag cacctgcgtc tcccgcacca   1080

gcacggcctc ggtcaccttc acagacaagg aaagggcctc ctgtcccacc tctacctaaa   1140

gtcaccccga caaaggaact gcagcaggag aacatcatca gtttctttga ggacaacttt   1200

gttccagaaa tcagtgtgac aacaccttcc cagaatgaag tccctgaggt gaagaaagag   1260

gagactttgc tggatctgga ctttgatcct ttcaagcccg aggtgacacc tgcaggttct   1320

gctggagtga cccactcacc catgtctcag acattgccct gggacctatg gacgacaagc   1380

actgatttgg tacagccggc ttctggtggt tcatttaatg gattcacaca gccccaggat   1440

acttcattat tcacaatgca gacagaccag agtatgatct gcaacttgat catacctgga   1500

gctgatgctg atgcagctgt tggaaccttg gtgtcagcag ctgagggggc cccaggagag   1560

gaagcagagg cggagaaggc cactgtccct gccggggaag gagtaagttt agaggaggcc   1620

aaaattggaa ctgaaaccac tgagggtgca gagagtgccc aacctgaagc agaggagctc   1680

gaagcaacag tgcctcagga gaaggtcatt ccttcggtgg tcatagagcc tgcctccaac   1740

catgaagagg aaggagaaaa cgaaataact ataggtgcag agcccaagga gaccaccgag   1800

gacgcggctc ctccgggccc caccagcgag acaccggagc tggctacgga gcagaagcct   1860

atccaggacc ctcagcccac gccttctgca ccagccatgg gggctgctga ccagctagca   1920

tctgcaaggg aggcctctca ggaattgcct cctggctttc tctacaaggt ggaaacactg   1980

catgattttg aggcagcaaa ttctgatgaa cttaccttac aaaggggtga tgtggtgctg   2040

gtggtcccct cagattcaga agctgatcag gatgcaggct ggctggtggg agtgaaggaa   2100

tcagactggc ttcagtacag agaccttgcc acctacaaag gcctctttcc agagaacttc   2160

acccgacgct tagattaggg caacaagtac tgcaagaagg agctcagtta cggggttttt   2220

aaaccttcat gaaaacctga agagttcact tttgttatta tgctcttaat gatttacaga   2280

ctgatgccag acaaaccttg ggaagatgta tcaatggagc atgtgtgcaa aaaaatgtaa   2340

gaggaaaaaa agtaaattaa ggaaaaaatc ctcactcatt cccatgttgt caataacagg   2400

tttgtttgtg ctttgtccaa gctgtggaga ctcttgtact tgatcccctc ccaccaattc   2460

taaagtagct ttctccagat cagactttaa tttctctgca tcaggtgtat cgtattgagt   2520

ggctgccctg cagaagatgt gatgaattat cctgtagtac aagattatct tattcccctg   2580

cccaggtgtg agcacgtgct ctcgctccct ttcaggttta ctatgtttaa aactaaactg   2640

ctgcaaaagt tctcaatgtt cttttccaac acatctatat atatatggac acacagtcac   2700

gcaagctagt tcccatgact cctggatcta tgtgtatgca gaaggctaca tatacatagt   2760

tgcttctttc ctttccattg tagctctttg cctctcaatt gtcattgata catgcattgc   2820

tcttattctg tctggcatta caattgcagt tttgcctaat ggcaaaacca gccatcccat   2880

tggcaaaaga gtcaacagta tctgtgtttg tactgtgcag ttttcaggat gagatgacag   2940

atagcacgac tacactgagg caccctcaga gaaggcaggg cctgatttat ctagctgtcc   3000

agccgctgtg gctggaggta ggctagttgg gatgggcagc taagcagtct tctcttctgc   3060

ctttatgaga ttgggtagaa agatggggca tattcatcta cccccaaaag aacactataa   3120

aaacagctcc tctatatttc cacctctttc tatttatgca actcatcttc acagattgtt   3180

ctaaagtaaa atagatggtg tatgctgtat ccacaaatca tctgtaacaa ttatgttttc   3240

agtgctgtgt cattccaaat aaacctttgg taatcttcaa cgattaccct aattcctttt   3300


<210>  3629
<211>  653
<212>  PRT
<213>  Homo sapiens

<400>  3629

Met Ala Asp Ile Lys Thr Gly Ile Phe Ala Lys Asn Val Gln Lys Arg 
1               5                   10                  15


Leu Asn Arg Ala Gln Glu Lys Val Leu Gln Lys Leu Gly Lys Ala Asp 
            20                  25                  30


Glu Thr Lys Asp Glu Gln Phe Glu Glu Tyr Val Gln Asn Phe Lys Arg 
        35                  40                  45


Gln Glu Ala Glu Gly Thr Arg Leu Gln Arg Glu Leu Arg Gly Tyr Leu 
    50                  55                  60


Ala Ala Ile Lys Gly Met Gln Glu Ala Ser Met Lys Leu Thr Glu Ser 
65                  70                  75                  80


Leu His Glu Val Tyr Glu Pro Asp Trp Tyr Gly Arg Glu Asp Val Lys 
                85                  90                  95


Met Val Gly Glu Lys Cys Asp Val Leu Trp Glu Asp Phe His Gln Lys 
            100                 105                 110


Leu Val Asp Gly Ser Leu Leu Thr Leu Asp Thr Tyr Leu Gly Gln Phe 
        115                 120                 125


Pro Asp Ile Lys Asn Arg Ile Ala Lys Arg Ser Arg Lys Leu Val Asp 
    130                 135                 140


Tyr Asp Ser Ala Arg His His Leu Glu Ala Leu Gln Ser Ser Lys Arg 
145                 150                 155                 160


Lys Asp Glu Ser Arg Ile Ser Lys Ala Glu Glu Glu Phe Gln Lys Ala 
                165                 170                 175


Gln Lys Val Phe Glu Glu Phe Asn Val Asp Leu Gln Glu Glu Leu Pro 
            180                 185                 190


Ser Leu Trp Ser Arg Arg Val Gly Phe Tyr Val Asn Thr Phe Lys Asn 
        195                 200                 205


Val Ser Ser Leu Glu Ala Lys Phe His Lys Glu Ile Ala Val Leu Cys 
    210                 215                 220


His Lys Leu Tyr Glu Val Met Thr Lys Leu Gly Asp Gln His Ala Asp 
225                 230                 235                 240


Lys Ala Phe Thr Ile Gln Gly Ala Pro Ser Asp Ser Gly Pro Leu Arg 
                245                 250                 255


Ile Ala Lys Thr Pro Ser Pro Pro Glu Glu Pro Ser Pro Leu Pro Ser 
            260                 265                 270


Pro Thr Ala Ser Pro Asn His Thr Leu Ala Pro Ala Ser Pro Ala Pro 
        275                 280                 285


Ala Arg Pro Arg Ser Pro Ser Gln Thr Arg Lys Gly Pro Pro Val Pro 
    290                 295                 300


Pro Leu Pro Lys Val Thr Pro Thr Lys Glu Leu Gln Gln Glu Asn Ile 
305                 310                 315                 320


Ile Ser Phe Phe Glu Asp Asn Phe Val Pro Glu Ile Ser Val Thr Thr 
                325                 330                 335


Pro Ser Gln Asn Glu Val Pro Glu Val Lys Lys Glu Glu Thr Leu Leu 
            340                 345                 350


Asp Leu Asp Phe Asp Pro Phe Lys Pro Glu Val Thr Pro Ala Gly Ser 
        355                 360                 365


Ala Gly Val Thr His Ser Pro Met Ser Gln Thr Leu Pro Trp Asp Leu 
    370                 375                 380


Trp Thr Thr Ser Thr Asp Leu Val Gln Pro Ala Ser Gly Gly Ser Phe 
385                 390                 395                 400


Asn Gly Phe Thr Gln Pro Gln Asp Thr Ser Leu Phe Thr Met Gln Thr 
                405                 410                 415


Asp Gln Ser Met Ile Cys Asn Leu Ile Ile Pro Gly Ala Asp Ala Asp 
            420                 425                 430


Ala Ala Val Gly Thr Leu Val Ser Ala Ala Glu Gly Ala Pro Gly Glu 
        435                 440                 445


Glu Ala Glu Ala Glu Lys Ala Thr Val Pro Ala Gly Glu Gly Val Ser 
    450                 455                 460


Leu Glu Glu Ala Lys Ile Gly Thr Glu Thr Thr Glu Gly Ala Glu Ser 
465                 470                 475                 480


Ala Gln Pro Glu Ala Glu Glu Leu Glu Ala Thr Val Pro Gln Glu Lys 
                485                 490                 495


Val Ile Pro Ser Val Val Ile Glu Pro Ala Ser Asn His Glu Glu Glu 
            500                 505                 510


Gly Glu Asn Glu Ile Thr Ile Gly Ala Glu Pro Lys Glu Thr Thr Glu 
        515                 520                 525


Asp Ala Ala Pro Pro Gly Pro Thr Ser Glu Thr Pro Glu Leu Ala Thr 
    530                 535                 540


Glu Gln Lys Pro Ile Gln Asp Pro Gln Pro Thr Pro Ser Ala Pro Ala 
545                 550                 555                 560


Met Gly Ala Ala Asp Gln Leu Ala Ser Ala Arg Glu Ala Ser Gln Glu 
                565                 570                 575


Leu Pro Pro Gly Phe Leu Tyr Lys Val Glu Thr Leu His Asp Phe Glu 
            580                 585                 590


Ala Ala Asn Ser Asp Glu Leu Thr Leu Gln Arg Gly Asp Val Val Leu 
        595                 600                 605


Val Val Pro Ser Asp Ser Glu Ala Asp Gln Asp Ala Gly Trp Leu Val 
    610                 615                 620


Gly Val Lys Glu Ser Asp Trp Leu Gln Tyr Arg Asp Leu Ala Thr Tyr 
625                 630                 635                 640


Lys Gly Leu Phe Pro Glu Asn Phe Thr Arg Arg Leu Asp 
                645                 650


<210>  3630
<211>  2057
<212>  DNA
<213>  Homo sapiens

<400>  3630
gaacataacg tctctaatca tgcatattca cgcagtgagg tagataatgt gaaagggctt     60

tgaacaatgt agtaagggaa agagactagg atactgactt cccattttcc caattcttgc    120

ttcagaactg ctctcctagg ccccaagccc ctacctctgt tagccccttg atcaatcttt    180

gcctgtccag gggcaaaact acgtaatatc ccaagaacag ggactaatat tacagcccca    240

tttcttttct ttgctatttc ccatgatcac tcttaaacca agaaacagat cttttctctg    300

attggtgggg cctcctcact agaacaaagg ggagaatgta cgtttcataa tagggattct    360

gtgatgaaat gacctaagga gataaatgta catttcataa taggcattct gtgatggaat    420

gtcctgaggg gataaaagct ggagtcggtc tcagcacatc tcagttactc attttgactc    480

gtttggacaa gtgagttact acagcgctga tttggaaaaa tgactagaaa gctacctcca    540

atttctcggc ctcaacccca gcctcatttt ctttctgttc cttcccgctc tcgtcttcca    600

gccctccttc cccccgttac tcctcaaact tcctgccgtc agcctcctct ccagagccgt    660

ccaagttgtt cgattttctg ccctacccgt ttgcccaagc tgactaatgt cgccccttcc    720

cagtacccta cctcaaggaa cttcctgccc ggcccttcct ctgttactac cagggcgtcc    780

gtgtgccgcc gccctgttcg tcaggcaccc ctttcccggt gtccccctat ctttccccct    840

caccctcctc atagcccttc tttctagtcc cctgtactct agtccccact ccctatccag    900

ccacccccaa ccagacctga cggcttgcaa atctcaccct ggagaaatgg tttccctcct    960

actggggcag ttcccaggcg gtccagaatt gccaggactt gtggattccc agcagcgacc   1020

tggcagacac ggggaatcca agaccatggc aagcgaacat tcggcctggc ctgcgccttt   1080

cctctcctgc ctgggcagcc agactgcaca agcctctgca tttgaactgg cttctccgtg   1140

gaacttggtt tgtaaccacg gagcaaactg caggaccagg ggcagagaag ttgatggcga   1200

gcctttttcc tggcagtatc cagaggcggt tctagtaaag aggctggatt ccgagaggcc   1260

agagcggtat catacgaacg ccgttgcctg gagacggagt ggggtgccat tgcctagaga   1320

ctgcagaagg cccgcagcca agcgagtggt aagaggacgc cgagagagcc ccggacccac   1380

ggagcagccc caaggctatg gcgggacacc cgaaagagag ggtggtcaca gatgaggtcc   1440

atcagaacca gatcttgcgg gagctgtacc tcaaagagtt acgaacccag aaactccaca   1500

cgcagtacca tgtgaatccc ctgcgcaagg ttcacaggat tacgaggaag cctatgtctt   1560

ggcatgataa cctggaggaa cccgcagacg ccaggtttct gaatctcatt caccatgctg   1620

cccaggggcc aacgaagaag tacccggagg cacagactga aaaccaggaa attgggtggg   1680

actcagaagc cttggtcgac ccagaacgcc gtgaccacag gatgaaccac ttcagggtct   1740

acagtgacat cactctgtac aaagctaaaa tgtggagctt gggagaagat gatcgccaca   1800

agtagcatct cagctgtgga gtcaggccct ggatttaatg ccctaaatat ccactgccta   1860

gaagactaaa cattatttta accccccgtc ccccatccat aattcatgga taatggcaaa   1920

aattaggaag cataaaaaat atgcggaaga aggaaataaa aattgcccat tatctcacca   1980

tatggaagtg actaatgtta gcattttaaa ccatttgttt ttaaaattaa taataaattg   2040

catatattta ttgtgta                                                  2057


<210>  3631
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  3631

Met Ser Pro Leu Pro Ser Thr Leu Pro Gln Gly Thr Ser Cys Pro Ala 
1               5                   10                  15


Leu Pro Leu Leu Leu Pro Gly Arg Pro Cys Ala Ala Ala Leu Phe Val 
            20                  25                  30


Arg His Pro Phe Pro Gly Val Pro Leu Ser Phe Pro Leu Thr Leu Leu 
        35                  40                  45


Ile Ala Leu Leu Ser Ser Pro Leu Tyr Ser Ser Pro His Ser Leu Ser 
    50                  55                  60


Ser His Pro Gln Pro Asp Leu Thr Ala Cys Lys Ser His Pro Gly Glu 
65                  70                  75                  80


Met Val Ser Leu Leu Leu Gly Gln Phe Pro Gly Gly Pro Glu Leu Pro 
                85                  90                  95


Gly Leu Val Asp Ser Gln Gln Arg Pro Gly Arg His Gly Glu Ser Lys 
            100                 105                 110


Thr Met Ala Ser Glu His Ser Ala Trp Pro Ala Pro Phe Leu Ser Cys 
        115                 120                 125


Leu Gly Ser Gln Thr Ala Gln Ala Ser Ala Phe Glu Leu Ala Ser Pro 
    130                 135                 140


Trp Asn Leu Val Cys Asn His Gly Ala Asn Cys Arg Thr Arg Gly Arg 
145                 150                 155                 160


Glu Val Asp Gly Glu Pro Phe Ser Trp Gln Tyr Pro Glu Ala Val Leu 
                165                 170                 175


Val Lys Arg Leu Asp Ser Glu Arg Pro Glu Arg Tyr His Thr Asn Ala 
            180                 185                 190


Val Ala Trp Arg Arg Ser Gly Val Pro Leu Pro Arg Asp Cys Arg Arg 
        195                 200                 205


Pro Ala Ala Lys Arg Val Val Arg Gly Arg Arg Glu Ser Pro Gly Pro 
    210                 215                 220


Thr Glu Gln Pro Gln Gly Tyr Gly Gly Thr Pro Glu Arg Glu Gly Gly 
225                 230                 235                 240


His Arg 



<210>  3632
<211>  3642
<212>  DNA
<213>  Homo sapiens

<400>  3632
tcgcatagca acatgattat aatacctgtt ttgtgtctga tcataccacc cctcaggaat     60

gcttttgtaa ataagccatt ctctaaaggc accttattgc tgaaaattaa actgcaactc    120

gactttcagt cgggattggt ttaaaatgat cttgcttgtt gcattaagtt ctcctccttt    180

ctctgccctc ctcgccagat gcagctaagc ccttcagcgt ggtggtcttc cattgccggc    240

acatgttcca caaggagtgc ctgcccatgc ccagcatgaa ctctgctgca cagttctgca    300

acatctgcag tgctaagaac cgtggaccag gaagtgcaat tttggagatg aaaaaatagc    360

tcatttctcc ttgtcagtct ccttgtcacc actctttttg agactgtttt tgcaacaaca    420

aaagcatttg ttgacactcg tgctgttaag agatttgttt atgtttatat tatactcaaa    480

aacaatttct tcatctattc ctgtactaat ggtttctctt tgcagttcac agagaatttg    540

gggctctctt catgccttga aattttgggg tccatagtga atattttgtt atttatttgt    600

ttggctcatt ctttatatag taatggaaac ataagtctag gagttagaaa tgaatttttt    660

agaccttagt aaaaccattt aaccataaaa tggacaactg agaattctcc cagctgcctg    720

aaagcgtcgc caactgtggt tatcctgcaa gctgctacct gcaacttgga cgttgtttcc    780

acgtgctctg ctggctacga ttcttgcatt ctgggtttgg cttttttctg tgtcatcaac    840

tatggttatc ctctaaatag gcatttaatg aaacattgta caaattgtca ctcatttgat    900

gacacctggg aataacatta gcaggctgat gtcctgcacc attatgttta ctaatcacat    960

gttctgtgtg ctgtgacgac tgtcaaagag tatctggcca tggcggacac tcagcatttg   1020

ttgattgaat aaatgttagc tcttctcatt gtgaaggact cacttttact gggataaaca   1080

aatgcagtta agaattctgg cacccttgta aggaagaaaa gagagttcaa caccttcgag   1140

tctgagcgct tgtggctaga gtttgccagg agggaggaaa ccagtgaccc tgaaaactga   1200

gggtgcctca ggagcagtgg gaccacctga tgctgaagga cggactaatg atgtttcctc   1260

ttgccttctc tggtgcctcc attgccctca tggaacagag catatcatag agggagaaaa   1320

gtcaaacttg taattgtgtc ttacagttac tggcttcatc ttccttggga tatatggtca   1380

tcctctaatg agtgtaaaag tgcgcaaaac acatccttat tgttcctgat ctcttagtcc   1440

cataaatggg aacaaataca gctttctgct tctttctttt tggggaaagg acagggtgct   1500

agtgagtact gacagcatgc cagctaccga agtcacccag ccattcccat gagcagcagt   1560

tcatttaatt gtcacagcgt cgccaggaag aagatctgat aaacctaggt ttacagataa   1620

agaaagcaaa atgtagagat gttgttgagg tcacagaggt gactgcctaa cttcagagca   1680

gggcttctga tccctttaag aaattacagg gccagccggg catggtggct cacgcccgta   1740

atcccagggc tttgggaggc cttggcaggt ggatcacctg agatcgcacg ttcgagacca   1800

gcctgaccaa catggagaaa ccccatctct actaaaaaca caaattagcc aggcgtggtg   1860

gtacatgcct gtaatcccag ctactcagga ggctgaggca ggagaatcac ttgaccccag   1920

gagacgtagg ttgtggtgag ctgagatcgc gccattgcac tccagcctgg gcaacaagag   1980

caaaactccg tctcaaaaaa gaaaagaaaa gaaaagaaat catagggcca agttcaaagg   2040

aaatgcacag aacatatctt cacattagag ttaagaattc tctagcaaac aacagatttt   2100

tttgttgttg ttagtcacaa atacttagaa ctggaaggct ctttgttatt attgaatgta   2160

cccctcagcc ttctcagcat ttccttatcc caagactagt gtgctttctg ctacactgct   2220

agttttcagt tttgttctta cccaattgtt ttttcttttc aacattacca atttacagat   2280

tcagtttatt acatttacat taatcctcac ttatgatttg agcaagctca tttccagaaa   2340

agtttacttt aagatcatca ataggatttg ctaatttcag tgaagtcatt ttgcttcagg   2400

ggtaaattat cctagttacc aagtcctatt tggacataaa gaaaatccta cttatagaaa   2460

aggagaaaat aattaaacag tcttcatttt taagtaactg atttaaaagg aaaataataa   2520

aatatgttcg tttatcattt cagaaattgc tgtaacacac tggaaaattc ctgaacaata   2580

tagattttat cgttaataaa aaacactagc tttcgttcct tagaatgtct tttcttttga   2640

ataaacagta ttgggtgatt tattaaagga tattcaatcc tttttacttt tcatcaacct   2700

ataagggctt aaatatggca aaataatcca agtgttagtc aattattttt catgtgtgac   2760

tagcccaatt taaaatatag gtaaaaagga aacccattcc cctcgttttg gggaagaaca   2820

tagttgcaaa gtacacactt cataagctat tctttttttt tttttttttt tttttttttt   2880

tgagatggag tctcgttctg ttgccttggc tggagtgcag tgacatgatc ttggctcact   2940

gcaacctccg cctcccaggt tcaagtgatt ctcccgtctc agcttccgga gtaggtggga   3000

gtacaggcac gcaccaccat gcccagctaa ttttttgtac tttggtagag atgaggtttc   3060

accatgttgc ccaagctggt ctcgaactcc tgagctcagg aatccgccca cctcggcctt   3120

ccgaagtgtt aggattacag gcgtaagtca ccatgcccag ccaagaaagc tattcttgaa   3180

gtgtaaaaca gccaggtgca aaattatttt ggagtacttt agtttgcttt tgtttttagc   3240

caaagggatt tcatactggt ttaattatgt tcatccttga gaatttttga gaagtttcca   3300

acagatttgt agttcatttt gctgttgtta caatgtaaag ctatatatag ttgacccttg   3360

aacaacacag gttggaactg caaggatcca cttatacatg gattttcttc tgcctctgcc   3420

acccttgaga cggcaagacc aggccctccc cttcctcctc cttctcagcc tactcagtat   3480

gaagacgaca gagatgaaac acttatgatg atccacttct acttaatgag tagtaaatat   3540

attttctttt ccttatgatt ttcttactat tttctttagc ttgctttatt ataagaatat   3600

agcatataat ataaataaaa tataaaatat gtgttaatgg tc                      3642


<210>  3633
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  3633

Met Phe His Lys Glu Cys Leu Pro Met Pro Ser Met Asn Ser Ala Ala 
1               5                   10                  15


Gln Phe Cys Asn Ile Cys Ser Ala Lys Asn Arg Gly Pro Gly Ser Ala 
            20                  25                  30


Ile Leu Glu Met Lys Lys 
        35


<210>  3634
<211>  5790
<212>  DNA
<213>  Homo sapiens

<400>  3634
gactctcccg tggcgccatg gcggaagcag aggagcagga aactgggtcc cttgaagaat     60

ctacagatga gtctgaggaa gaagagagcg aagaggaacc caagctgaag tatgaaaggc    120

tttccaatgg ggtaactgaa atacttcaga aggatgcagc tagctgcatg acagtccatg    180

acaagttttt ggcattgggc acacattatg gcaaggttta tttacttgat gtccagggga    240

acatcactca gaagtttgat gtagtgcagg tatttggact gtattctgga gaagaatttc    300

acgagacttt tgactgtccc attaaaatta ttgctgtgca cccacatttc gtgagatcca    360

gttgcaagca gtttgtgacc ggagggaaga agctgctact gtttgaacgg tcttggatga    420

acagatggaa gtctgctgtt ctgcatgaag gggaagggaa cataaggagt gtgaagtgga    480

gaggccatct gattgcttgg gccaataata tgggtgtgaa gatttttgac atcatctcaa    540

agcaaagaat caccaatgtg ccccgggatg atataagtct tcgcccagac atgtatccct    600

gcagcctctg ctggaaggac aatgtgacac tgattattgg ctgggggact tctgtcaagg    660

tgtgctcagt gaaggaacgg catgccagtg aaatgaggga tttgccaagt cgatatgttg    720

aaatagtgtc tcagtttgaa actgaattct acatcagtgg acttgcacct ctctgtgatc    780

agcttgttgt actttcgtat gtaaaggaga tttcagaaaa aacggaaaga gaatactgtg    840

ccaggcctag actggacatc atccagccac tttctgagac ttgtgaagag atctcttctg    900

atgctttgac agtcagaggc tttcaggaga atgaatgtag agattatcat ttagaatact    960

ctgaagggga atcacttttt tacatcgtga gtccgagaga tgttgtagtg gccaaggaac   1020

gagaccaaga tgatcacatt gactggctcc ttgaaaagaa gaaatatgaa gaagcattga   1080

tggcagctga aattagccaa aaaaatatta aaagacataa gattctggat attggcttgg   1140

catatataaa tcacctggtg gagagaggag actatgacat agcagcacgc aaatgccaga   1200

aaattcttgg gaaaaatgca gcactctggg aatatgaagt ttataaattt aaagaaattg   1260

gacagcttaa ggctattagt ccttatttgc caagaggtga tccagttctg aaaccactca   1320

tctatgaaat gatcttacat gaatttttgg agagtgatta tgagggtttt gccacattga   1380

tccgagaatg gcctggagat ctgtataata attcagtcat agttcaagca gttcgggatc   1440

atttgaagaa agatagtcag aacaagactt tacttaaaac cctggcagaa ttgtacacct   1500

atgacaagaa ctatggcaat gctctggaaa tatacttaac attaagacat aaagacgttt   1560

ttcagttgat ccacaagcat aatcttttca gttctatcaa ggataaaatt gttttattaa   1620

tggattttga ttcagagaaa gctgttgaca tgcttttgga caatgaagat aaaatttcaa   1680

ttaaaaaggt agtggaagaa ttggaagaca gaccagagct acagcatgtg tatttgcata   1740

agcttttcaa gagagaccac cataaggggc agcgttacca tgaaaaacag atcagtcttt   1800

atgctgaata tgatcgacca aacttacttc cctttctccg agacagtacc cattgcccac   1860

ttgaaaaggc tcttgagatc tgtcaacaga gaaactttgt agaagagaca gtttatcttc   1920

tgagccgaat gggtaatagc cgaagtgccc tgaagatgat tatggaggaa ttacatgatg   1980

ttgataaagc aatcgaattt gccaaggagc aagatgatgg agagctgtgg gaagatttga   2040

ttttatattc cattgacaaa ccaccattta ttactggctt gttaaacaac attggcacac   2100

atgttgaccc aattctactg attcaccgta ttaaggaagg aatggagatc cccaatttga   2160

gagattcctt ggttaaaatt ctgcaagact acaatttgca aattctgctt cgtgaaggct   2220

gcaagaagat tctcgtagct gactctttgt ccttactgaa gaaaatgcac cgaactcaaa   2280

tgaaaggtgt tcttgttgat gaggagaaca tctgtgagtc gtgcctttcc cctattcttc   2340

catcagatgc agctaagccc ttcagcgtgg tggtcttcca ttgccggcac atgttccaca   2400

aggagtgcct gcccatgccc agcatgaact ctgctgcaca gttctgcaac atctgcagtg   2460

ctaagaaccg tggaccagga agtgcaattt tggagatgaa aaaatagctc atttctcctt   2520

gtcagtctcc ttgtcaccac tctttttgag actgtttttg caacaacaaa agcatttgtt   2580

gacactcgtg ctgttaagag atttgtttat gtttatatta tactcaaaaa caatttcttc   2640

atctattcct gtactaatgg tttctctttg cagttcacag agaatttggg gctctcttca   2700

tgccttgaaa ttttggggtc catagtgaat attttgttat ttatttgttt ggctcattct   2760

ttatatagta atggaaacat aagtctagga gttagaaatg aattttttag accttagtaa   2820

aaccatttaa ccataaaatg gacaactgag aattctccca gctgcctgaa agcgtcgcca   2880

actgtggtta tcctgcaagc tgctacctgc aacttggacg ttgtttccac gtgctctgct   2940

ggctacgatt cttgcattct gggtttggct tttttctgtg tcatcaacta tggttatcct   3000

ctaaataggc atttaatgaa acattgtaca aattgtcact catttgatga cacctgggaa   3060

taacattagc aggctgatgt cctgcaccat tatgtttact aatcacatgt tctgtgtgct   3120

gtgacgactg tcaaagagta tctggccatg gcggacactc agcatttgtt gattgaataa   3180

atgttagctc ttctcattgt gaaggactca cttttactgg gataaacaaa tgcagttaag   3240

aattctggca cccttgtaag gaagaaaaga gagttcaaca ccttcgagtc tgagcgcttg   3300

tggctagagt ttgccaggag ggaggaaacc agtgaccctg aaaactgagg gtgcctcagg   3360

agcagtggga ccacctgatg ctgaaggacg gactaatgat gtttcctctt gccttctctg   3420

gtgcctccat tgccctcatg gaacagagca tatcatagag ggagaaaagt caaacttgta   3480

attgtgtctt acagttactg gcttcatctt ccttgggata tatggtcatc ctctaatgag   3540

tgtaaaagtg cgcaaaacac atccttattg ttcctgatct cttagtccca taaatgggaa   3600

caaatacagc tttctgcttc tttctttttg gggaaaggac agggtgctag tgagtactga   3660

cagcatgcca gctaccgaag tcacccagcc attcccatga gcagcagttc atttaattgt   3720

cacagcgtcg ccaggaagaa gatctgataa acctaggttt acagataaag aaagcaaaat   3780

gtagagatgt tgttgaggtc acagaggtga ctgcctaact tcagagcagg gcttctgatc   3840

cctttaagaa attacagggc cagccgggca tggtggctca cgcccgtaat cccagggctt   3900

tgggaggcct tggcaggtgg atcacctgag atcgcacgtt cgagaccagc ctgaccaaca   3960

tggagaaacc ccatctctac taaaaacaca aattagccag gcgtggtggt acatgcctgt   4020

aatcccagct actcaggagg ctgaggcagg agaatcactt gaccccagga gacgtaggtt   4080

gtggtgagct gagatcgcgc cattgcactc cagcctgggc aacaagagca aaactccgtc   4140

tcaaaaaaga aaagaaaaga aaagaaatca tagggccaag ttcaaaggaa atgcacagaa   4200

catatcttca cattagagtt aagaattctc tagcaaacaa cagatttttt tgttgttgtt   4260

agtcacaaat acttagaact ggaaggctct ttgttattat tgaatgtacc cctcagcctt   4320

ctcagcattt ccttatccca agactagtgt gctttctgct acactgctag ttttcagttt   4380

tgttcttacc caattgtttt ttcttttcaa cattaccaat ttacagattc agtttattac   4440

atttacatta atcctcactt atgatttgag caagctcatt tccagaaaag tttactttaa   4500

gatcatcaat aggatttgct aatttcagtg aagtcatttt gcttcagggg taaattatcc   4560

tagttaccaa gtcctatttg gacataaaga aaatcctact tatagaaaag gagaaaataa   4620

ttaaacagtc ttcattttta agtaactgat ttaaaaggaa aataataaaa tatgttcgtt   4680

tatcatttca gaaattgctg taacacactg gaaaattcct gaacaatata gattttatcg   4740

ttaataaaaa acactagctt tcgttcctta gaatgtcttt tcttttgaat aaacagtatt   4800

gggtgattta ttaaaggata ttcaatcctt tttacttttc atcaacctat aagggcttaa   4860

atatggcaaa ataatccaag tgttagtcaa ttatttttca tgtgtgacta gcccaattta   4920

aaatataggt aaaaaggaaa cccattcccc tcgttttggg gaagaacata gttgcaaagt   4980

acacacttca taagctattc tttttttttt tttttttttt tttttttttg agatggagtc   5040

tcgttctgtt gccttggctg gagtgcagtg acatgatctt ggctcactgc aacctccgcc   5100

tcccaggttc aagtgattct cccgtctcag cttccggagt aggtgggagt acaggcacgc   5160

accaccatgc ccagctaatt ttttgtactt tggtagagat gaggtttcac catgttgccc   5220

aagctggtct cgaactcctg agctcaggaa tccgcccacc tcggccttcc gaagtgttag   5280

gattacaggc gtaagtcacc atgcccagcc aagaaagcta ttcttgaagt gtaaaacagc   5340

caggtgcaaa attattttgg agtactttag tttgcttttg tttttagcca aagggatttc   5400

atactggttt aattatgttc atccttgaga atttttgaga agtttccaac agatttgtag   5460

ttcattttgc tgttgttaca atgtaaagct atatatagtt gacccttgaa caacacaggt   5520

tggaactgca aggatccact tatacatgga ttttcttctg cctctgccac ccttgagacg   5580

gcaagaccag gccctcccct tcctcctcct tctcagccta ctcagtatga agacgacaga   5640

gatgaaacac ttatgatgat ccacttctac ttaatgagta gtaaatatat tttcttttcc   5700

ttatgatttt cttactattt tctttagctt gctttattat aagaatatag catataatat   5760

aaataaaata taaaatatgt gttaatggtc                                    5790


<210>  3635
<211>  829
<212>  PRT
<213>  Homo sapiens

<400>  3635

Met Ala Glu Ala Glu Glu Gln Glu Thr Gly Ser Leu Glu Glu Ser Thr 
1               5                   10                  15


Asp Glu Ser Glu Glu Glu Glu Ser Glu Glu Glu Pro Lys Leu Lys Tyr 
            20                  25                  30


Glu Arg Leu Ser Asn Gly Val Thr Glu Ile Leu Gln Lys Asp Ala Ala 
        35                  40                  45


Ser Cys Met Thr Val His Asp Lys Phe Leu Ala Leu Gly Thr His Tyr 
    50                  55                  60


Gly Lys Val Tyr Leu Leu Asp Val Gln Gly Asn Ile Thr Gln Lys Phe 
65                  70                  75                  80


Asp Val Val Gln Val Phe Gly Leu Tyr Ser Gly Glu Glu Phe His Glu 
                85                  90                  95


Thr Phe Asp Cys Pro Ile Lys Ile Ile Ala Val His Pro His Phe Val 
            100                 105                 110


Arg Ser Ser Cys Lys Gln Phe Val Thr Gly Gly Lys Lys Leu Leu Leu 
        115                 120                 125


Phe Glu Arg Ser Trp Met Asn Arg Trp Lys Ser Ala Val Leu His Glu 
    130                 135                 140


Gly Glu Gly Asn Ile Arg Ser Val Lys Trp Arg Gly His Leu Ile Ala 
145                 150                 155                 160


Trp Ala Asn Asn Met Gly Val Lys Ile Phe Asp Ile Ile Ser Lys Gln 
                165                 170                 175


Arg Ile Thr Asn Val Pro Arg Asp Asp Ile Ser Leu Arg Pro Asp Met 
            180                 185                 190


Tyr Pro Cys Ser Leu Cys Trp Lys Asp Asn Val Thr Leu Ile Ile Gly 
        195                 200                 205


Trp Gly Thr Ser Val Lys Val Cys Ser Val Lys Glu Arg His Ala Ser 
    210                 215                 220


Glu Met Arg Asp Leu Pro Ser Arg Tyr Val Glu Ile Val Ser Gln Phe 
225                 230                 235                 240


Glu Thr Glu Phe Tyr Ile Ser Gly Leu Ala Pro Leu Cys Asp Gln Leu 
                245                 250                 255


Val Val Leu Ser Tyr Val Lys Glu Ile Ser Glu Lys Thr Glu Arg Glu 
            260                 265                 270


Tyr Cys Ala Arg Pro Arg Leu Asp Ile Ile Gln Pro Leu Ser Glu Thr 
        275                 280                 285


Cys Glu Glu Ile Ser Ser Asp Ala Leu Thr Val Arg Gly Phe Gln Glu 
    290                 295                 300


Asn Glu Cys Arg Asp Tyr His Leu Glu Tyr Ser Glu Gly Glu Ser Leu 
305                 310                 315                 320


Phe Tyr Ile Val Ser Pro Arg Asp Val Val Val Ala Lys Glu Arg Asp 
                325                 330                 335


Gln Asp Asp His Ile Asp Trp Leu Leu Glu Lys Lys Lys Tyr Glu Glu 
            340                 345                 350


Ala Leu Met Ala Ala Glu Ile Ser Gln Lys Asn Ile Lys Arg His Lys 
        355                 360                 365


Ile Leu Asp Ile Gly Leu Ala Tyr Ile Asn His Leu Val Glu Arg Gly 
    370                 375                 380


Asp Tyr Asp Ile Ala Ala Arg Lys Cys Gln Lys Ile Leu Gly Lys Asn 
385                 390                 395                 400


Ala Ala Leu Trp Glu Tyr Glu Val Tyr Lys Phe Lys Glu Ile Gly Gln 
                405                 410                 415


Leu Lys Ala Ile Ser Pro Tyr Leu Pro Arg Gly Asp Pro Val Leu Lys 
            420                 425                 430


Pro Leu Ile Tyr Glu Met Ile Leu His Glu Phe Leu Glu Ser Asp Tyr 
        435                 440                 445


Glu Gly Phe Ala Thr Leu Ile Arg Glu Trp Pro Gly Asp Leu Tyr Asn 
    450                 455                 460


Asn Ser Val Ile Val Gln Ala Val Arg Asp His Leu Lys Lys Asp Ser 
465                 470                 475                 480


Gln Asn Lys Thr Leu Leu Lys Thr Leu Ala Glu Leu Tyr Thr Tyr Asp 
                485                 490                 495


Lys Asn Tyr Gly Asn Ala Leu Glu Ile Tyr Leu Thr Leu Arg His Lys 
            500                 505                 510


Asp Val Phe Gln Leu Ile His Lys His Asn Leu Phe Ser Ser Ile Lys 
        515                 520                 525


Asp Lys Ile Val Leu Leu Met Asp Phe Asp Ser Glu Lys Ala Val Asp 
    530                 535                 540


Met Leu Leu Asp Asn Glu Asp Lys Ile Ser Ile Lys Lys Val Val Glu 
545                 550                 555                 560


Glu Leu Glu Asp Arg Pro Glu Leu Gln His Val Tyr Leu His Lys Leu 
                565                 570                 575


Phe Lys Arg Asp His His Lys Gly Gln Arg Tyr His Glu Lys Gln Ile 
            580                 585                 590


Ser Leu Tyr Ala Glu Tyr Asp Arg Pro Asn Leu Leu Pro Phe Leu Arg 
        595                 600                 605


Asp Ser Thr His Cys Pro Leu Glu Lys Ala Leu Glu Ile Cys Gln Gln 
    610                 615                 620


Arg Asn Phe Val Glu Glu Thr Val Tyr Leu Leu Ser Arg Met Gly Asn 
625                 630                 635                 640


Ser Arg Ser Ala Leu Lys Met Ile Met Glu Glu Leu His Asp Val Asp 
                645                 650                 655


Lys Ala Ile Glu Phe Ala Lys Glu Gln Asp Asp Gly Glu Leu Trp Glu 
            660                 665                 670


Asp Leu Ile Leu Tyr Ser Ile Asp Lys Pro Pro Phe Ile Thr Gly Leu 
        675                 680                 685


Leu Asn Asn Ile Gly Thr His Val Asp Pro Ile Leu Leu Ile His Arg 
    690                 695                 700


Ile Lys Glu Gly Met Glu Ile Pro Asn Leu Arg Asp Ser Leu Val Lys 
705                 710                 715                 720


Ile Leu Gln Asp Tyr Asn Leu Gln Ile Leu Leu Arg Glu Gly Cys Lys 
                725                 730                 735


Lys Ile Leu Val Ala Asp Ser Leu Ser Leu Leu Lys Lys Met His Arg 
            740                 745                 750


Thr Gln Met Lys Gly Val Leu Val Asp Glu Glu Asn Ile Cys Glu Ser 
        755                 760                 765


Cys Leu Ser Pro Ile Leu Pro Ser Asp Ala Ala Lys Pro Phe Ser Val 
    770                 775                 780


Val Val Phe His Cys Arg His Met Phe His Lys Glu Cys Leu Pro Met 
785                 790                 795                 800


Pro Ser Met Asn Ser Ala Ala Gln Phe Cys Asn Ile Cys Ser Ala Lys 
                805                 810                 815


Asn Arg Gly Pro Gly Ser Ala Ile Leu Glu Met Lys Lys 
            820                 825


<210>  3636
<211>  1542
<212>  DNA
<213>  Homo sapiens

<400>  3636
ttagtaaaac catttaacca taaaatggac aactgagaat tctcccagct gcctgaaagc     60

gtcgccaact gtggttatcc tgcaagctgc tacctgcaac ttggacgttg tttccacgtg    120

ctctgctggc tacgattctt gcattctggg tttggctttt ttctgtgtca tcaactatgg    180

ttatcctcta aataggcatt taatgaaaca ttgtacaaat tgtcactcat ttgatgacac    240

ctgggaataa cattagcagg ctgatgtcct gcaccattat gtttactaat cacatgttct    300

gtgtgctgtg acgactgtca aagagtatct ggccatggcg gacactcagc atttgttgat    360

tgaataaatg ttagctcttc tcattgtgaa ggactcactt ttactgggat aaacaaatgc    420

agttaagaat tctggcaccc ttgtaaggaa gaaaagagag ttcaacacct tcgagtctga    480

gcgcttgtgg ctagagtttg ccaggaggga ggaaaccagt gaccctgaaa actgagggtg    540

cctcaggagc agtgggacca cctgatgctg aaggacggac taatgatgtt tcctcttgcc    600

ttctctggtg cctccattgc cctcatggaa cagagcatat catagaggga gaaaagtcaa    660

acttgtaatt gtgtcttaca gttactggct tcatcttcct tgggatatat ggtcatcctc    720

taatgagtgt aaaagtgcgc aaaacacatc cttattgttc ctgatctctt agtcccataa    780

atgggaacaa atacagcttt ctgcttcttt ctttttgggg aaaggacagg gtgctagtga    840

gtactgacag catgccagct accgaagtca cccagccatt cccatgagca gcagttcatt    900

taattgtcac agcgtcgcca ggaagaagat ctgataaacc taggtttaca gataaagaaa    960

gcaaaatgta gagatgttgt tgaggtcaca gaggtgactg cctaacttca gagcagggct   1020

tctgatccct ttaagaaatt acagggcgta agtcaccatg cccagccaag aaagctattc   1080

ttgaagtgta aaacagccag gtgcaaaatt attttggagt actttagttt gcttttgttt   1140

ttagccaaag ggatttcata ctggtttaat tatgttcatc cttgagaatt tttgagaagt   1200

ttccaacaga tttgtagttc attttgctgt tgttacaatg taaagctata tatagttgac   1260

ccttgaacaa cacaggttgg aactgcaagg atccacttat acatggattt tcttctgcct   1320

ctgccaccct tgagacggca agaccaggcc ctccccttcc tcctccttct cagcctactc   1380

agtatgaaga cgacagagat gaaacactta tgatgatcca cttctactta atgagtagta   1440

aatatatttt cttttcctta tgattttctt actattttct ttagcttgct ttattataag   1500

aatatagcat ataatataaa taaaatataa aatatgtgtt aa                      1542


<210>  3637
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  3637

Met Asp Phe Leu Leu Pro Leu Pro Pro Leu Arg Arg Gln Asp Gln Ala 
1               5                   10                  15


Leu Pro Phe Leu Leu Leu Leu Ser Leu Leu Ser Met Lys Thr Thr Glu 
            20                  25                  30


Met Lys His Leu 
        35


<210>  3638
<211>  986
<212>  DNA
<213>  Homo sapiens

<400>  3638
tctcaaaaaa gaaaagaaaa gaaaagaaat catagggcca agttcaaagg aaatgcacag     60

aacatatctt cacattagag ttaagaattc tctagcaaac aacagatttt tttgttgttg    120

ttagtcacaa atacttagaa ctggaaggct ctttgttatt attgaatgta cccctcagcc    180

ttctcagcat ttccttatcc caagactagt gtgctttctg ctacactgct agttttcagt    240

tttgttctta cccaattgtt ttttcttttc aacattacca atttacagat tcagtttatt    300

acatttacat taatcctcac ttatgatttg agcaagctca tttccagaaa agtttacttt    360

aagatcatca ataggatttg ctaatttcag tgaagtcatt ttgcttcagg ggtaaattat    420

cctagttacc aagtcctatt tggacataaa gaaaatccta cttatagaaa aggagaaaat    480

aattaaacag tcttcatttt taagtaactg atttaaaagg aaaataataa aatatgttcg    540

tttatcattt cagaaattgc tgtaacacac tggaaaattc ctgaacaata tagattttat    600

cgttaataaa aaacactagc tttcgttcct tagaataatt tttgagaagt ttccaacaga    660

tttgtagttc attttgctgt tgttacaatg taaagctata tatagttgac ccttgaacaa    720

cacaggttgg aactgcaagg atccacttat acatggattt tcttctgcct ctgccaccct    780

tgagacggca agaccaggcc ctccccttcc tcctccttct cagcctactc agtatgaaga    840

cgacagagat gaaacactta tgatgatcca cttctactta atgagtagta aatatatttt    900

cttttcctta tgattttctt actattttct ttagcttgct ttattataag aatatagcat    960

ataatataaa taaaatataa aatatg                                         986


<210>  3639
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  3639

Met Tyr Pro Ser Ala Phe Ser Ala Phe Pro Tyr Pro Lys Thr Ser Val 
1               5                   10                  15


Leu Ser Ala Thr Leu Leu Val Phe Ser Phe Val Leu Thr Gln Leu Phe 
            20                  25                  30


Phe Leu Phe Asn Ile Thr Asn Leu Gln Ile Gln Phe Ile Thr Phe Thr 
        35                  40                  45


Leu Ile Leu Thr Tyr Asp Leu Ser Lys Leu Ile Ser Arg Lys Val Tyr 
    50                  55                  60


Phe Lys Ile Ile Asn Arg Ile Cys 
65                  70


<210>  3640
<211>  4908
<212>  DNA
<213>  Homo sapiens

<400>  3640
ctcttatttc cgggtctgtc aggtgactct cccgtggcgc catggcggaa gcagaggagc     60

aggaaactgg gtcccttgaa gaatctacag atgagtctga ggaagaagag agcgaagagg    120

aacccaagct gaagtatgaa aggctttcca atggggtaac tgaaatactt cagaaggatg    180

cagctagctg catgacagtc catgacaagt ttttggcatt gggcacacat tatggcaagg    240

tttatttact tgatgtccag gggaacatca ctcagaagtt tgatgtaagt cctgtgaaga    300

taaatcagat tagcttggat gaaagtggag agcacatggg tgtgtgttca gaggatggca    360

aggtgcaggt atttggactg tattctggag aagaatttca cgagactttt gactgtccca    420

ttaaaattat tgctgtgcac ccacatttcg tgagatccag ttgcaagcag tttgtgaccg    480

gagggaagaa gctgctactg tttgaacggt cttggatgaa cagatggaag tctgctgttc    540

tgcatgaagg ggaagggaac ataaggagtg tgaagtggag aggccatctg attgcttggg    600

ccaataatat gggtgtgaag atttttgaca tcatctcaaa gcaaagaatc accaatgtgc    660

cccgggatga tataagtctt cgcccagaca tgtatccctg cagcctctgc tggaaggaca    720

atgtgacact gattattggc tgggggactt ctgtcaaggt gtgctcagtg aaggaacggc    780

atgccagtga aatgagggat ttgccaagtc gatatgttga aatagtgtct cagtttgaaa    840

ctgaattcta catcagtgga cttgcacctc tctgtgatca gcttgttgta ctttcgtatg    900

taaaggagat ttcagaaaaa acggaaagag aatactgtgc caggcctaga ctggacatca    960

tccagccact ttctgagact tgtgaagaga tctcttctga tgctttgaca gtcagaggct   1020

ttcaggagaa tgaatgtaga gattatcatt tagaatactc tgaaggggaa tcactttttt   1080

acatcgtgag tccgagagat gttgtagtgg ccaaggaacg agaccaagat gatcacattg   1140

actggctcct tgaaaagaag aaatatgaag aagcattgat ggcagctgaa attagccaaa   1200

aaaatattaa aagacataag attctggata ttggcttggc atatataaat cacctggtgg   1260

agagaggaga ctatgacata gcagcacgca aatgccagaa aattcttggg aaaaatgcag   1320

cactctggga atatgaagtt tataaattta aagaaattgg acagcttaag gctattagtc   1380

cttatttgcc aagaggtgat ccagttctga aaccactcat ctatgaaatg atcttacatg   1440

aatttttgga gagtgattat gagggttttg ccacattgat ccgagaatgg cctggagatc   1500

tgtataataa ttcagtcata gttcaagcag ttcgggatca tttgaagaaa gatagtcaga   1560

acaagacttt acttaaaacc ctggcagaat tgtacaccta tgacaagaac tatggcaatg   1620

ctctggaaat atacttaaca ttaagacata aagacgtttt tcagttgatc cacaagcata   1680

atcttttcag ttctatcaag gataaaattg ttttattaat ggattttgat tcagagaaag   1740

ctgttgacat gcttttggac aatgaagata aaatttcaat taaaaaggta gtggaagaat   1800

tggaagacag accagagcta cagcatgtgt atttgcataa gcttttcaag agagaccacc   1860

ataaggggca gcgttaccat gaaaaacaga tcagtcttta tgctgaatat gatcgaccaa   1920

acttacttcc ctttctccga gacagtaccc attgcccact tgaaaaggct cttgagatct   1980

gtcaacagag aaactttgta gaagagacag tttatcttct gagccgaatg ggtaatagcc   2040

gaagtgccct gaagatgatt atggaggaat tacatgatgt tgataaagca atcgaatttg   2100

ccaaggagca agatgatgga gagctgtggg aagatttgat tttatattcc attgacaaac   2160

caccatttat tactggcttg ttaaacaaca ttggcacaca tgttgaccca attctactga   2220

ttcaccgtat taaggaagga atggagatcc ccaatttgag agattccttg gttaaaattc   2280

tgcaagacta caatttgcaa attctgcttc gtgaaggctg caagaagatt ctcgtagctg   2340

actctttgtc cttactgaag aaaatgcacc gaactcaaat gaaaggtgtt cttgttgatg   2400

aggagaacat ctgtgagtcg tgcctttccc ctattcttcc atcagatgca gctaagccct   2460

tcagcgtggt ggtcttccat tgccggcaca tgttccacaa ggagtgcctg cccatgccca   2520

gcatgaactc tgctgcacag ttctgcaaca tctgcagtgc taagaaccgt ggaccaggaa   2580

gtgcaatttt ggagatgaaa aaatagctca tttctccttg tcagtctcct tgtcaccact   2640

ctttttgaga ctgtttttgc aacaacaaaa gcatttgttg acactcgtgc tgttaagaga   2700

tttgtttatg tttatattat actcaaaaac aatttcttca tctattcctg tactaatggt   2760

ttctctttgc agttcacaga gaatttgggg ctctcttcat gccttgaaat tttggggtcc   2820

atagtgaata ttttgttatt tatttgtttg gctcattctt tatatagtaa tggaaacata   2880

agtctaggag ttagaaatga attttttaga ccttagtaaa accatttaac cataaaatgg   2940

acaactgaga attctcccag ctgcctgaaa gcgtcgccaa ctgtggttat cctgcaagct   3000

gctacctgca acttggacgt tgtttccacg tgctctgctg gctacgattc ttgcattctg   3060

ggtttggctt ttttctgtgt catcaactat ggttatcctc taaataggca tttaatgaaa   3120

cattgtacaa attgtcactc atttgatgac acctgggaat aacattagca ggctgatgtc   3180

ctgcaccatt atgtttacta atcacatgtt ctgtgtgctg tgacgactgt caaagagtat   3240

ctggccatgg cggacactca gcatttgttg attgaataaa tgttagctct tctcattgtg   3300

aaggactcac ttttactggg ataaacaaat gcagttaaga attctggcac ccttgtaagg   3360

aagaaaagag agttcaacac cttcgagtct gagcgcttgt ggctagagtt tgccaggagg   3420

gaggaaacca gtgaccctga aaactgaggg tgcctcagga gcagtgggac cacctgatgc   3480

tgaaggacgg actaatgatg tttcctcttg ccttctctgg tgcctccatt gccctcatgg   3540

aacagagcat atcatagagg gagaaaagtc aaacttgtaa ttgtgtctta cagttactgg   3600

cttcatcttc cttgggatat atggtcatcc tctaatgagt gtaaaagtgc gcaaaacaca   3660

tccttattgt tcctgatctc ttagtcccat aaatgggaac aaatacagct ttctgcttct   3720

ttctttttgg ggaaaggaca gggtgctagt gagtactgac agcatgccag ctaccgaagt   3780

cacccagcca ttcccatgag cagcagttca tttaattgtc acagcgtcgc caggaagaag   3840

atctgataaa cctaggttta cagataaaga aagcaaaatg tagagatgtt gttgaggtca   3900

cagaggtgac tgcctaactt cagagcaggg cttctgatcc ctttaagaaa ttacagggcc   3960

agccgggcat ggtggctcac gcccgtaatc ccagggcttt gggaggcctt ggcaggtgga   4020

tcacctgaga tcgcacgttc gagaccagcc tgaccaacat ggagaaaccc catctctact   4080

aaaaacacaa attagccagg cgtggtggta catgcctgta atcccagcta ctcaggaggc   4140

tgaggcagga gaatcacttg accccaggag acgtaggttg tggtgagctg agatcgcgcc   4200

attgcactcc agcctgggca acaagagcaa aactccgtct caaaaaagaa aagaaaagaa   4260

aagaaatcat agggccaagt tcaaaggaaa tgcacagaac atatcttcac attagagtta   4320

agaattctct agcaaacaac agattttttt gttgttgtta gtcacaaata cttagaactg   4380

gaaggctctt tgttattatt gaatgtaccc ctcagccttc tcagcatttc cttatcccaa   4440

gactagtgtg ctttctgcta cactgctagt tttcagtttt gttcttaccc aattgttttt   4500

tcttttcaac attaccaatt tacagattca gtttattaca tttacattaa tcctcactta   4560

tgatttgagc aagctcattt ccagaaaagt ttactttaag atcatcaata ggatttgcta   4620

atttcagtga agtcattttg cttcaggggt aaattatcct agttaccaag tcctatttgg   4680

acataaagaa aatcctactt atagaaaagg agaaaataat taaacagtct tcatttttaa   4740

gtaactgatt taaaaggaaa ataataaaat atgttcgttt atcatttcag aaattgctgt   4800

aacacactgg aaaattcctg aacaatatag attttatcgt taataaaaaa cactagcttt   4860

cgttccttag aatgtctttt cttttgaata aacagtattg ggtgattt                4908


<210>  3641
<211>  854
<212>  PRT
<213>  Homo sapiens

<400>  3641

Met Ala Glu Ala Glu Glu Gln Glu Thr Gly Ser Leu Glu Glu Ser Thr 
1               5                   10                  15


Asp Glu Ser Glu Glu Glu Glu Ser Glu Glu Glu Pro Lys Leu Lys Tyr 
            20                  25                  30


Glu Arg Leu Ser Asn Gly Val Thr Glu Ile Leu Gln Lys Asp Ala Ala 
        35                  40                  45


Ser Cys Met Thr Val His Asp Lys Phe Leu Ala Leu Gly Thr His Tyr 
    50                  55                  60


Gly Lys Val Tyr Leu Leu Asp Val Gln Gly Asn Ile Thr Gln Lys Phe 
65                  70                  75                  80


Asp Val Ser Pro Val Lys Ile Asn Gln Ile Ser Leu Asp Glu Ser Gly 
                85                  90                  95


Glu His Met Gly Val Cys Ser Glu Asp Gly Lys Val Gln Val Phe Gly 
            100                 105                 110


Leu Tyr Ser Gly Glu Glu Phe His Glu Thr Phe Asp Cys Pro Ile Lys 
        115                 120                 125


Ile Ile Ala Val His Pro His Phe Val Arg Ser Ser Cys Lys Gln Phe 
    130                 135                 140


Val Thr Gly Gly Lys Lys Leu Leu Leu Phe Glu Arg Ser Trp Met Asn 
145                 150                 155                 160


Arg Trp Lys Ser Ala Val Leu His Glu Gly Glu Gly Asn Ile Arg Ser 
                165                 170                 175


Val Lys Trp Arg Gly His Leu Ile Ala Trp Ala Asn Asn Met Gly Val 
            180                 185                 190


Lys Ile Phe Asp Ile Ile Ser Lys Gln Arg Ile Thr Asn Val Pro Arg 
        195                 200                 205


Asp Asp Ile Ser Leu Arg Pro Asp Met Tyr Pro Cys Ser Leu Cys Trp 
    210                 215                 220


Lys Asp Asn Val Thr Leu Ile Ile Gly Trp Gly Thr Ser Val Lys Val 
225                 230                 235                 240


Cys Ser Val Lys Glu Arg His Ala Ser Glu Met Arg Asp Leu Pro Ser 
                245                 250                 255


Arg Tyr Val Glu Ile Val Ser Gln Phe Glu Thr Glu Phe Tyr Ile Ser 
            260                 265                 270


Gly Leu Ala Pro Leu Cys Asp Gln Leu Val Val Leu Ser Tyr Val Lys 
        275                 280                 285


Glu Ile Ser Glu Lys Thr Glu Arg Glu Tyr Cys Ala Arg Pro Arg Leu 
    290                 295                 300


Asp Ile Ile Gln Pro Leu Ser Glu Thr Cys Glu Glu Ile Ser Ser Asp 
305                 310                 315                 320


Ala Leu Thr Val Arg Gly Phe Gln Glu Asn Glu Cys Arg Asp Tyr His 
                325                 330                 335


Leu Glu Tyr Ser Glu Gly Glu Ser Leu Phe Tyr Ile Val Ser Pro Arg 
            340                 345                 350


Asp Val Val Val Ala Lys Glu Arg Asp Gln Asp Asp His Ile Asp Trp 
        355                 360                 365


Leu Leu Glu Lys Lys Lys Tyr Glu Glu Ala Leu Met Ala Ala Glu Ile 
    370                 375                 380


Ser Gln Lys Asn Ile Lys Arg His Lys Ile Leu Asp Ile Gly Leu Ala 
385                 390                 395                 400


Tyr Ile Asn His Leu Val Glu Arg Gly Asp Tyr Asp Ile Ala Ala Arg 
                405                 410                 415


Lys Cys Gln Lys Ile Leu Gly Lys Asn Ala Ala Leu Trp Glu Tyr Glu 
            420                 425                 430


Val Tyr Lys Phe Lys Glu Ile Gly Gln Leu Lys Ala Ile Ser Pro Tyr 
        435                 440                 445


Leu Pro Arg Gly Asp Pro Val Leu Lys Pro Leu Ile Tyr Glu Met Ile 
    450                 455                 460


Leu His Glu Phe Leu Glu Ser Asp Tyr Glu Gly Phe Ala Thr Leu Ile 
465                 470                 475                 480


Arg Glu Trp Pro Gly Asp Leu Tyr Asn Asn Ser Val Ile Val Gln Ala 
                485                 490                 495


Val Arg Asp His Leu Lys Lys Asp Ser Gln Asn Lys Thr Leu Leu Lys 
            500                 505                 510


Thr Leu Ala Glu Leu Tyr Thr Tyr Asp Lys Asn Tyr Gly Asn Ala Leu 
        515                 520                 525


Glu Ile Tyr Leu Thr Leu Arg His Lys Asp Val Phe Gln Leu Ile His 
    530                 535                 540


Lys His Asn Leu Phe Ser Ser Ile Lys Asp Lys Ile Val Leu Leu Met 
545                 550                 555                 560


Asp Phe Asp Ser Glu Lys Ala Val Asp Met Leu Leu Asp Asn Glu Asp 
                565                 570                 575


Lys Ile Ser Ile Lys Lys Val Val Glu Glu Leu Glu Asp Arg Pro Glu 
            580                 585                 590


Leu Gln His Val Tyr Leu His Lys Leu Phe Lys Arg Asp His His Lys 
        595                 600                 605


Gly Gln Arg Tyr His Glu Lys Gln Ile Ser Leu Tyr Ala Glu Tyr Asp 
    610                 615                 620


Arg Pro Asn Leu Leu Pro Phe Leu Arg Asp Ser Thr His Cys Pro Leu 
625                 630                 635                 640


Glu Lys Ala Leu Glu Ile Cys Gln Gln Arg Asn Phe Val Glu Glu Thr 
                645                 650                 655


Val Tyr Leu Leu Ser Arg Met Gly Asn Ser Arg Ser Ala Leu Lys Met 
            660                 665                 670


Ile Met Glu Glu Leu His Asp Val Asp Lys Ala Ile Glu Phe Ala Lys 
        675                 680                 685


Glu Gln Asp Asp Gly Glu Leu Trp Glu Asp Leu Ile Leu Tyr Ser Ile 
    690                 695                 700


Asp Lys Pro Pro Phe Ile Thr Gly Leu Leu Asn Asn Ile Gly Thr His 
705                 710                 715                 720


Val Asp Pro Ile Leu Leu Ile His Arg Ile Lys Glu Gly Met Glu Ile 
                725                 730                 735


Pro Asn Leu Arg Asp Ser Leu Val Lys Ile Leu Gln Asp Tyr Asn Leu 
            740                 745                 750


Gln Ile Leu Leu Arg Glu Gly Cys Lys Lys Ile Leu Val Ala Asp Ser 
        755                 760                 765


Leu Ser Leu Leu Lys Lys Met His Arg Thr Gln Met Lys Gly Val Leu 
    770                 775                 780


Val Asp Glu Glu Asn Ile Cys Glu Ser Cys Leu Ser Pro Ile Leu Pro 
785                 790                 795                 800


Ser Asp Ala Ala Lys Pro Phe Ser Val Val Val Phe His Cys Arg His 
                805                 810                 815


Met Phe His Lys Glu Cys Leu Pro Met Pro Ser Met Asn Ser Ala Ala 
            820                 825                 830


Gln Phe Cys Asn Ile Cys Ser Ala Lys Asn Arg Gly Pro Gly Ser Ala 
        835                 840                 845


Ile Leu Glu Met Lys Lys 
    850


<210>  3642
<211>  2621
<212>  DNA
<213>  Homo sapiens

<400>  3642
tcgcatagca acatgattat aatacctgtt ttgtgtctga tcataccacc cctcaggaat     60

gcttttgtaa ataagccatt ctctaaaggc accttattgc tgaaaattaa actgcaactc    120

gactttcagt cgggattggt ttaaaatgat cttgcttgtt gcattaagtt ctcctccttt    180

ctctgccctc ctcgccagat gcagctaagc ccttcagcgt ggtggtcttc cattgccggc    240

acatgttcca caaggagtgc ctgcccatgc ccagcatgaa ctctgctgca cagttctgca    300

acatctgcag tgctaagaac cgtggaccag gaagtgcaat tttggagatg aaaaaatagc    360

tcatttctcc ttgtcagtct ccttgtcacc actctttttg agactgtttt tgcaacaaca    420

aaagcatttg ttgacactcg tgctgttaag agatttgttt atgtttatat tatactcaaa    480

aacaatttct tcatctattc ctgtactaat ggtttctctt tgcagttcac agagaatttg    540

gggctctctt catgccttga aattttgggg tccatagtga atattttgtt atttatttgt    600

ttggctcatt ctttatatag taatggaaac ataagtctag gagttagaaa tgaatttttt    660

agaccttagt aaaaccattt aaccataaaa tggacaactg agaattctcc cagctgcctg    720

aaagcgtcgc caactgtggt tatcctgcaa gctgctacct gcaacttgga cgttgtttcc    780

acgtgctctg ctggctacga ttcttgcatt ctgggtttgg cttttttctg tgtcatcaac    840

tatggttatc ctctaaatag gcatttaatg aaacattgta caaattgtca ctcatttgat    900

gacacctggg aataacatta gcaggctgat gtcctgcacc attatgttta ctaatcacat    960

gttctgtgtg ctgtgacgac tgtcaaagag tatctggcca tggcggacac tcagcatttg   1020

ttgattgaat aaatgttagc tcttctcatt gtgaaggact cacttttact gggataaaca   1080

aatgcagtta agaattctgg cacccttgta aggaagaaaa gagagttcaa caccttcgag   1140

tctgagcgct tgtggctaga gtttgccagg agggaggaaa ccagtgaccc tgaaaactga   1200

gggtgcctca ggagcagtgg gaccacctga tgctgaagga cggactaatg atgtttcctc   1260

ttgccttctc tggtgcctcc attgccctca tggaacagag catatcatag agggagaaaa   1320

gtcaaacttg taattgtgtc ttacagttac tggcttcatc ttccttggga tatatggtca   1380

tcctctaatg agtgtaaaag tgcgcaaaac acatccttat tgttcctgat ctcttagtcc   1440

cataaatggg aacaaataca gctttctgct tctttctttt tggggaaagg acagggtgct   1500

agtgagtact gacagcatgc cagctaccga agtcacccag ccattcccat gagcagcagt   1560

tcatttaatt gtcacagcgt cgccaggaag aagatctgat aaacctaggt ttacagataa   1620

agaaagcaaa atgtagagat gttgttgagg tcacagaggt gactgcctaa cttcagagca   1680

gggcttctga tccctttaag aaattacagg gccagccggg catggtggct cacgcccgta   1740

atcccagggc tttgggaggc cttggcaggt ggatcacctg agatcgcacg ttcgagacca   1800

gcctgaccaa catggagaaa ccccatctct actaaaaaca caaattagcc aggcgtggtg   1860

gtacatgcct gtaatcccag ctactcagga ggctgaggca ggagaatcac ttgaccccag   1920

gagacgtagg ttgtggtgag ctgagatcgc gccattgcac tccagcctgg gcaacaagag   1980

caaaactccg tctcaaaaaa gaaaagaaaa gaaaagaaat catagggcca agttcaaagg   2040

aaatgcacag aacatatctt cacattagag ttaagaattc tctagcaaac aacagatttt   2100

tttgttgttg ttagtcacaa atacttagaa ctggaaggct ctttgttatt attgaatgta   2160

cccctcagcc ttctcagcat ttccttatcc caagactagt gtgctttctg ctacactgct   2220

agttttcagt tttgttctta cccaattgtt ttttcttttc aacattacca atttacagat   2280

tcagtttatt acatttacat taatcctcac ttatgatttg agcaagctca tttccagaaa   2340

agtttacttt aagatcatca ataggatttg ctaatttcag tgaagtcatt ttgcttcagg   2400

ggtaaattat cctagttacc aagtcctatt tggacataaa gaaaatccta cttatagaaa   2460

aggagaaaat aattaaacag tcttcatttt taagtaactg atttaaaagg aaaataataa   2520

aatatgttcg tttatcattt cagaaattgc tgtaacacac tggaaaattc ctgaacaata   2580

tagattttat cgttaataaa aaacactagc tttcgttcct t                       2621


<210>  3643
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  3643

Met Phe His Lys Glu Cys Leu Pro Met Pro Ser Met Asn Ser Ala Ala 
1               5                   10                  15


Gln Phe Cys Asn Ile Cys Ser Ala Lys Asn Arg Gly Pro Gly Ser Ala 
            20                  25                  30


Ile Leu Glu Met Lys Lys 
        35


<210>  3644
<211>  4769
<212>  DNA
<213>  Homo sapiens

<400>  3644
gactctcccg tggcgccatg gcggaagcag aggagcagga aactgggtcc cttgaagaat     60

ctacagatga gtctgaggaa gaagagagcg aagaggaacc caagctgaag tatgaaaggc    120

tttccaatgg ggtaactgaa atacttcaga aggatgcagc tagctgcatg acagtccatg    180

acaagttttt ggcattgggc acacattatg gcaaggttta tttacttgat gtccagggga    240

acatcactca gaagtttgat gtagtgcagg tatttggact gtattctgga gaagaatttc    300

acgagacttt tgactgtccc attaaaatta ttgctgtgca cccacatttc gtgagatcca    360

gttgcaagca gtttgtgacc ggagggaaga agctgctact gtttgaacgg tcttggatga    420

acagatggaa gtctgctgtt ctgcatgaag gggaagggaa cataaggagt gtgaagtgga    480

gaggccatct gattgcttgg gccaataata tgggtgtgaa gatttttgac atcatctcaa    540

agcaaagaat caccaatgtg ccccgggatg atataagtct tcgcccagac atgtatccct    600

gcagcctctg ctggaaggac aatgtgacac tgattattgg ctgggggact tctgtcaagg    660

tgtgctcagt gaaggaacgg catgccagtg aaatgaggga tttgccaagt cgatatgttg    720

aaatagtgtc tcagtttgaa actgaattct acatcagtgg acttgcacct ctctgtgatc    780

agcttgttgt actttcgtat gtaaaggaga tttcagaaaa aacggaaaga gaatactgtg    840

ccaggcctag actggacatc atccagccac tttctgagac ttgtgaagag atctcttctg    900

atgctttgac agtcagaggc tttcaggaga atgaatgtag agattatcat ttagaatact    960

ctgaagggga atcacttttt tacatcgtga gtccgagaga tgttgtagtg gccaaggaac   1020

gagaccaaga tgatcacatt gactggctcc ttgaaaagaa gaaatatgaa gaagcattga   1080

tggcagctga aattagccaa aaaaatatta aaagacataa gattctggat attggcttgg   1140

catatataaa tcacctggtg gagagaggag actatgacat agcagcacgc aaatgccaga   1200

aaattcttgg gaaaaatgca gcactctggg aatatgaagt ttataaattt aaagaaattg   1260

gacagcttaa ggctattagt ccttatttgc caagaggtga tccagttctg aaaccactca   1320

tctatgaaat gatcttacat gaatttttgg agagtgatta tgagggtttt gccacattga   1380

tccgagaatg gcctggagat ctgtataata attcagtcat agttcaagca gttcgggatc   1440

atttgaagaa agatagtcag aacaagactt tacttaaaac cctggcagaa ttgtacacct   1500

atgacaagaa ctatggcaat gctctggaaa tatacttaac attaagacat aaagacgttt   1560

ttcagttgat ccacaagcat aatcttttca gttctatcaa ggataaaatt gttttattaa   1620

tggattttga ttcagagaaa gctgttgaca tgcttttgga caatgaagat aaaatttcaa   1680

ttaaaaaggt agtggaagaa ttggaagaca gaccagagct acagcatgtg tatttgcata   1740

agcttttcaa gagagaccac cataaggggc agcgttacca tgaaaaacag atcagtcttt   1800

atgctgaata tgatcgacca aacttacttc cctttctccg agacagtacc cattgcccac   1860

ttgaaaaggc tcttgagatc tgtcaacaga gaaactttgt agaagagaca gtttatcttc   1920

tgagccgaat gggtaatagc cgaagtgccc tgaagatgat tatggaggaa ttacatgatg   1980

ttgataaagc aatcgaattt gccaaggagc aagatgatgg agagctgtgg gaagatttga   2040

ttttatattc cattgacaaa ccaccattta ttactggctt gttaaacaac attggcacac   2100

atgttgaccc aattctactg attcaccgta ttaaggaagg aatggagatc cccaatttga   2160

gagattcctt ggttaaaatt ctgcaagact acaatttgca aattctgctt cgtgaaggct   2220

gcaagaagat tctcgtagct gactctttgt ccttactgaa gaaaatgcac cgaactcaaa   2280

tgaaaggtgt tcttgttgat gaggagaaca tctgtgagtc gtgcctttcc cctattcttc   2340

catcagatgc agctaagccc ttcagcgtgg tggtcttcca ttgccggcac atgttccaca   2400

aggagtgcct gcccatgccc agcatgaact ctgctgcaca gttctgcaac atctgcagtg   2460

ctaagaaccg tggaccagga agtgcaattt tggagatgaa aaaatagctc atttctcctt   2520

gtcagtctcc ttgtcaccac tctttttgag actgtttttg caacaacaaa agcatttgtt   2580

gacactcgtg ctgttaagag atttgtttat gtttatatta tactcaaaaa caatttcttc   2640

atctattcct gtactaatgg tttctctttg cagttcacag agaatttggg gctctcttca   2700

tgccttgaaa ttttggggtc catagtgaat attttgttat ttatttgttt ggctcattct   2760

ttatatagta atggaaacat aagtctagga gttagaaatg aattttttag accttagtaa   2820

aaccatttaa ccataaaatg gacaactgag aattctccca gctgcctgaa agcgtcgcca   2880

actgtggtta tcctgcaagc tgctacctgc aacttggacg ttgtttccac gtgctctgct   2940

ggctacgatt cttgcattct gggtttggct tttttctgtg tcatcaacta tggttatcct   3000

ctaaataggc atttaatgaa acattgtaca aattgtcact catttgatga cacctgggaa   3060

taacattagc aggctgatgt cctgcaccat tatgtttact aatcacatgt tctgtgtgct   3120

gtgacgactg tcaaagagta tctggccatg gcggacactc agcatttgtt gattgaataa   3180

atgttagctc ttctcattgt gaaggactca cttttactgg gataaacaaa tgcagttaag   3240

aattctggca cccttgtaag gaagaaaaga gagttcaaca ccttcgagtc tgagcgcttg   3300

tggctagagt ttgccaggag ggaggaaacc agtgaccctg aaaactgagg gtgcctcagg   3360

agcagtggga ccacctgatg ctgaaggacg gactaatgat gtttcctctt gccttctctg   3420

gtgcctccat tgccctcatg gaacagagca tatcatagag ggagaaaagt caaacttgta   3480

attgtgtctt acagttactg gcttcatctt ccttgggata tatggtcatc ctctaatgag   3540

tgtaaaagtg cgcaaaacac atccttattg ttcctgatct cttagtccca taaatgggaa   3600

caaatacagc tttctgcttc tttctttttg gggaaaggac agggtgctag tgagtactga   3660

cagcatgcca gctaccgaag tcacccagcc attcccatga gcagcagttc atttaattgt   3720

cacagcgtcg ccaggaagaa gatctgataa acctaggttt acagataaag aaagcaaaat   3780

gtagagatgt tgttgaggtc acagaggtga ctgcctaact tcagagcagg gcttctgatc   3840

cctttaagaa attacagggc cagccgggca tggtggctca cgcccgtaat cccagggctt   3900

tgggaggcct tggcaggtgg atcacctgag atcgcacgtt cgagaccagc ctgaccaaca   3960

tggagaaacc ccatctctac taaaaacaca aattagccag gcgtggtggt acatgcctgt   4020

aatcccagct actcaggagg ctgaggcagg agaatcactt gaccccagga gacgtaggtt   4080

gtggtgagct gagatcgcgc cattgcactc cagcctgggc aacaagagca aaactccgtc   4140

tcaaaaaaga aaagaaaaga aaagaaatca tagggccaag ttcaaaggaa atgcacagaa   4200

catatcttca cattagagtt aagaattctc tagcaaacaa cagatttttt tgttgttgtt   4260

agtcacaaat acttagaact ggaaggctct ttgttattat tgaatgtacc cctcagcctt   4320

ctcagcattt ccttatccca agactagtgt gctttctgct acactgctag ttttcagttt   4380

tgttcttacc caattgtttt ttcttttcaa cattaccaat ttacagattc agtttattac   4440

atttacatta atcctcactt atgatttgag caagctcatt tccagaaaag tttactttaa   4500

gatcatcaat aggatttgct aatttcagtg aagtcatttt gcttcagggg taaattatcc   4560

tagttaccaa gtcctatttg gacataaaga aaatcctact tatagaaaag gagaaaataa   4620

ttaaacagtc ttcattttta agtaactgat ttaaaaggaa aataataaaa tatgttcgtt   4680

tatcatttca gaaattgctg taacacactg gaaaattcct gaacaatata gattttatcg   4740

ttaataaaaa acactagctt tcgttcctt                                     4769


<210>  3645
<211>  829
<212>  PRT
<213>  Homo sapiens

<400>  3645

Met Ala Glu Ala Glu Glu Gln Glu Thr Gly Ser Leu Glu Glu Ser Thr 
1               5                   10                  15


Asp Glu Ser Glu Glu Glu Glu Ser Glu Glu Glu Pro Lys Leu Lys Tyr 
            20                  25                  30


Glu Arg Leu Ser Asn Gly Val Thr Glu Ile Leu Gln Lys Asp Ala Ala 
        35                  40                  45


Ser Cys Met Thr Val His Asp Lys Phe Leu Ala Leu Gly Thr His Tyr 
    50                  55                  60


Gly Lys Val Tyr Leu Leu Asp Val Gln Gly Asn Ile Thr Gln Lys Phe 
65                  70                  75                  80


Asp Val Val Gln Val Phe Gly Leu Tyr Ser Gly Glu Glu Phe His Glu 
                85                  90                  95


Thr Phe Asp Cys Pro Ile Lys Ile Ile Ala Val His Pro His Phe Val 
            100                 105                 110


Arg Ser Ser Cys Lys Gln Phe Val Thr Gly Gly Lys Lys Leu Leu Leu 
        115                 120                 125


Phe Glu Arg Ser Trp Met Asn Arg Trp Lys Ser Ala Val Leu His Glu 
    130                 135                 140


Gly Glu Gly Asn Ile Arg Ser Val Lys Trp Arg Gly His Leu Ile Ala 
145                 150                 155                 160


Trp Ala Asn Asn Met Gly Val Lys Ile Phe Asp Ile Ile Ser Lys Gln 
                165                 170                 175


Arg Ile Thr Asn Val Pro Arg Asp Asp Ile Ser Leu Arg Pro Asp Met 
            180                 185                 190


Tyr Pro Cys Ser Leu Cys Trp Lys Asp Asn Val Thr Leu Ile Ile Gly 
        195                 200                 205


Trp Gly Thr Ser Val Lys Val Cys Ser Val Lys Glu Arg His Ala Ser 
    210                 215                 220


Glu Met Arg Asp Leu Pro Ser Arg Tyr Val Glu Ile Val Ser Gln Phe 
225                 230                 235                 240


Glu Thr Glu Phe Tyr Ile Ser Gly Leu Ala Pro Leu Cys Asp Gln Leu 
                245                 250                 255


Val Val Leu Ser Tyr Val Lys Glu Ile Ser Glu Lys Thr Glu Arg Glu 
            260                 265                 270


Tyr Cys Ala Arg Pro Arg Leu Asp Ile Ile Gln Pro Leu Ser Glu Thr 
        275                 280                 285


Cys Glu Glu Ile Ser Ser Asp Ala Leu Thr Val Arg Gly Phe Gln Glu 
    290                 295                 300


Asn Glu Cys Arg Asp Tyr His Leu Glu Tyr Ser Glu Gly Glu Ser Leu 
305                 310                 315                 320


Phe Tyr Ile Val Ser Pro Arg Asp Val Val Val Ala Lys Glu Arg Asp 
                325                 330                 335


Gln Asp Asp His Ile Asp Trp Leu Leu Glu Lys Lys Lys Tyr Glu Glu 
            340                 345                 350


Ala Leu Met Ala Ala Glu Ile Ser Gln Lys Asn Ile Lys Arg His Lys 
        355                 360                 365


Ile Leu Asp Ile Gly Leu Ala Tyr Ile Asn His Leu Val Glu Arg Gly 
    370                 375                 380


Asp Tyr Asp Ile Ala Ala Arg Lys Cys Gln Lys Ile Leu Gly Lys Asn 
385                 390                 395                 400


Ala Ala Leu Trp Glu Tyr Glu Val Tyr Lys Phe Lys Glu Ile Gly Gln 
                405                 410                 415


Leu Lys Ala Ile Ser Pro Tyr Leu Pro Arg Gly Asp Pro Val Leu Lys 
            420                 425                 430


Pro Leu Ile Tyr Glu Met Ile Leu His Glu Phe Leu Glu Ser Asp Tyr 
        435                 440                 445


Glu Gly Phe Ala Thr Leu Ile Arg Glu Trp Pro Gly Asp Leu Tyr Asn 
    450                 455                 460


Asn Ser Val Ile Val Gln Ala Val Arg Asp His Leu Lys Lys Asp Ser 
465                 470                 475                 480


Gln Asn Lys Thr Leu Leu Lys Thr Leu Ala Glu Leu Tyr Thr Tyr Asp 
                485                 490                 495


Lys Asn Tyr Gly Asn Ala Leu Glu Ile Tyr Leu Thr Leu Arg His Lys 
            500                 505                 510


Asp Val Phe Gln Leu Ile His Lys His Asn Leu Phe Ser Ser Ile Lys 
        515                 520                 525


Asp Lys Ile Val Leu Leu Met Asp Phe Asp Ser Glu Lys Ala Val Asp 
    530                 535                 540


Met Leu Leu Asp Asn Glu Asp Lys Ile Ser Ile Lys Lys Val Val Glu 
545                 550                 555                 560


Glu Leu Glu Asp Arg Pro Glu Leu Gln His Val Tyr Leu His Lys Leu 
                565                 570                 575


Phe Lys Arg Asp His His Lys Gly Gln Arg Tyr His Glu Lys Gln Ile 
            580                 585                 590


Ser Leu Tyr Ala Glu Tyr Asp Arg Pro Asn Leu Leu Pro Phe Leu Arg 
        595                 600                 605


Asp Ser Thr His Cys Pro Leu Glu Lys Ala Leu Glu Ile Cys Gln Gln 
    610                 615                 620


Arg Asn Phe Val Glu Glu Thr Val Tyr Leu Leu Ser Arg Met Gly Asn 
625                 630                 635                 640


Ser Arg Ser Ala Leu Lys Met Ile Met Glu Glu Leu His Asp Val Asp 
                645                 650                 655


Lys Ala Ile Glu Phe Ala Lys Glu Gln Asp Asp Gly Glu Leu Trp Glu 
            660                 665                 670


Asp Leu Ile Leu Tyr Ser Ile Asp Lys Pro Pro Phe Ile Thr Gly Leu 
        675                 680                 685


Leu Asn Asn Ile Gly Thr His Val Asp Pro Ile Leu Leu Ile His Arg 
    690                 695                 700


Ile Lys Glu Gly Met Glu Ile Pro Asn Leu Arg Asp Ser Leu Val Lys 
705                 710                 715                 720


Ile Leu Gln Asp Tyr Asn Leu Gln Ile Leu Leu Arg Glu Gly Cys Lys 
                725                 730                 735


Lys Ile Leu Val Ala Asp Ser Leu Ser Leu Leu Lys Lys Met His Arg 
            740                 745                 750


Thr Gln Met Lys Gly Val Leu Val Asp Glu Glu Asn Ile Cys Glu Ser 
        755                 760                 765


Cys Leu Ser Pro Ile Leu Pro Ser Asp Ala Ala Lys Pro Phe Ser Val 
    770                 775                 780


Val Val Phe His Cys Arg His Met Phe His Lys Glu Cys Leu Pro Met 
785                 790                 795                 800


Pro Ser Met Asn Ser Ala Ala Gln Phe Cys Asn Ile Cys Ser Ala Lys 
                805                 810                 815


Asn Arg Gly Pro Gly Ser Ala Ile Leu Glu Met Lys Lys 
            820                 825


<210>  3646
<211>  3561
<212>  DNA
<213>  Homo sapiens

<400>  3646
ctcttatttc cgggtctgtc aggtgactct cccgtggcgc catggcggaa gcagaggagc     60

aggaaactgg gtcccttgaa gaatctacag atgagtctga ggaagaagag agcgaagagg    120

aacccaagct gaagtatgaa aggctttcca atggggtaac tgaaatactt cagaaggatg    180

cagctagctg catgacagtc catgacaagt ttttggcatt gggcacacat tatggcaagg    240

tttatttact tgatgtccag gggaacatca ctcagaagtt tgatgtaagt cctgtgaaga    300

taaatcagat tagcttggat gaaagtggag agcacatggg tgtgtgttca gaggatggca    360

aggtgcaggt atttggactg tattctggag aagaatttca cgagactttt gactgtccca    420

ttaaaattat tgctgtgcac ccacatttcg tgagatccag ttgcaagcag tttgtgaccg    480

gagggaagaa gctgctactg tttgaacggt cttggatgaa cagatggaag tctgctgttc    540

tgcatgaagg ggaagggaac ataaggagtg tgaagtggag aggccatctg attgcttggg    600

ccaataatat gggtgtgaag atttttgaca tcatctcaaa gcaaagaatc accaatgtgc    660

cccgggatga tataagtctt cgcccagaca tgtatccctg cagcctctgc tggaaggaca    720

atgtgacact gattattggc tgggggactt ctgtcaaggt gtgctcagtg aaggaacggc    780

atgccagtga aatgagggat ttgccaagtc gatatgttga aatagtgtct cagtttgaaa    840

ctgaattcta catcagtgga cttgcacctc tctgtgatca gcttgttgta ctttcgtatg    900

taaaggagat ttcagaaaaa acggaaagag aatactgtgc caggcctaga ctggacatca    960

tccagccact ttctgagact tgtgaagaga tctcttctga tgctttgaca gtcagaggct   1020

ttcaggagaa tgaatgtaga gattatcatt tagaatactc tgaaggggaa tcactttttt   1080

acatcgtgag tccgagagat gttgtagtgg ccaaggaacg agaccaagat gatcacattg   1140

actggctcct tgaaaagaag aaatatgaag aagcattgat ggcagctgaa attagccaaa   1200

aaaatattaa aagacataag attctggata ttggcttggc atatataaat cacctggtgg   1260

agagaggaga ctatgacata gcagcacgca aatgccagaa aattcttggg aaaaatgcag   1320

cactctggga atatgaagtt tataaattta aagaaattgg acagcttaag gctattagtc   1380

cttatttgcc aagaggtgat ccagttctga aaccactcat ctatgaaatg atcttacatg   1440

aatttttgga gagtgattat gagggttttg ccacattgat ccgagaatgg cctggagatc   1500

tgtataataa ttcagtcata gttcaagcag ttcgggatca tttgaagaaa gatagtcaga   1560

acaagacttt acttaaaacc ctggcagaat tgtacaccta tgacaagaac tatggcaatg   1620

ctctggaaat atacttaaca ttaagacata aagacgtttt tcagttgatc cacaagcata   1680

atcttttcag ttctatcaag gataaaattg ttttattaat ggattttgat tcagagaaag   1740

ctgttgacat gcttttggac aatgaagata aaatttcaat taaaaaggta gtggaagaat   1800

tggaagacag accagagcta cagcatgtgt atttgcataa gcttttcaag agagaccacc   1860

ataaggggca gcgttaccat gaaaaacaga tcagtcttta tgctgaatat gatcgaccaa   1920

acttacttcc ctttctccga gacagtaccc attgcccact tgaaaaggct cttgagatct   1980

gtcaacagag aaactttgta gaagagacag tttatcttct gagccgaatg ggtaatagcc   2040

gaagtgccct gaagatgatt atggaggaat tacatgatgt tgataaagca atcgaatttg   2100

ccaaggagca agatgatgga gagctgtggg aagatttgat tttatattcc attgacaaac   2160

caccatttat tactggcttg ttaaacaaca ttggcacaca tgttgaccca attctactga   2220

ttcaccgtat taaggaagga atggagatcc ccaatttgag agattccttg gttaaaattc   2280

tgcaagacta caatttgcaa attctgcttc gtgaaggctg caagaagatt ctcgtagctg   2340

actctttgtc cttactgaag aaaatgcacc gaactcaaat gaaaggtgtt cttgttgatg   2400

aggagaacat ctgtgagtcg tgcctttccc ctattcttcc atcagatgca gctaagccct   2460

tcagcgtggt ggtcttccat tgccggcaca tgttccacaa ggagtgcctg cccatgccca   2520

gcatgaactc tgctgcacag ttctgcaaca tctgcagtgc taagaaccgt ggaccaggaa   2580

gtgcaatttt ggagatgaaa aaatagctca tttctccttg tcagtctcct tgtcaccact   2640

ctttttgaga ctgtttttgc aacaacaaaa gcatttgttg acactcgtgc tgttaagaga   2700

tttgtttatg tttatattat actcaaaaac aatttcttca tctattcctg tactaatggt   2760

ttctctttgc agttcacaga gaatttgggg ctctcttcat gccttgaaat tttggggtcc   2820

atagtgaata ttttgttatt tatttgtttg gctcattctt tatatagtaa tggaaacata   2880

agtctaggag ttagaaatga attttttaga ccttagtaaa accatttaac cataaaatgg   2940

acaactgaga attctcccag ctgcctgaaa gcgtcgccaa ctgtggttat cctgcaagct   3000

gctacctgca acttggacgt tgtttccacg tgctctgctg gctacgattc ttgcattctg   3060

ggtttggctt ttttctgtgt catcaactat ggttatcctc taaataggca tttaatgaaa   3120

cattgtacaa attgtcactc atttgatgac acctgggaat aacattagca ggctgatgtc   3180

ctgcaccatt atgtttacta atcacatgtt ctgtgtgctg tgacgactgt caaagagtat   3240

ctggccatgg cggacactca gcatttgttg attgaataaa tgttagctct tctcattgtg   3300

aaggactcac ttttactggg ataaacaaat gcagttaaga attctggcac ccttgtaagg   3360

aagaaaagag agttcaacac cttcgagtct gagcgcttgt ggctagagtt tgccaggagg   3420

gaggaaacca gtgaccctga aaactgaggg tgcctcagga gcagtgggac cacctgatgc   3480

tgaaggacgg actaatgatg tttcctcttg ccttctctgg tgcctccatt gccctcatgg   3540

aacagagcat atcatagagg g                                             3561


<210>  3647
<211>  854
<212>  PRT
<213>  Homo sapiens

<400>  3647

Met Ala Glu Ala Glu Glu Gln Glu Thr Gly Ser Leu Glu Glu Ser Thr 
1               5                   10                  15


Asp Glu Ser Glu Glu Glu Glu Ser Glu Glu Glu Pro Lys Leu Lys Tyr 
            20                  25                  30


Glu Arg Leu Ser Asn Gly Val Thr Glu Ile Leu Gln Lys Asp Ala Ala 
        35                  40                  45


Ser Cys Met Thr Val His Asp Lys Phe Leu Ala Leu Gly Thr His Tyr 
    50                  55                  60


Gly Lys Val Tyr Leu Leu Asp Val Gln Gly Asn Ile Thr Gln Lys Phe 
65                  70                  75                  80


Asp Val Ser Pro Val Lys Ile Asn Gln Ile Ser Leu Asp Glu Ser Gly 
                85                  90                  95


Glu His Met Gly Val Cys Ser Glu Asp Gly Lys Val Gln Val Phe Gly 
            100                 105                 110


Leu Tyr Ser Gly Glu Glu Phe His Glu Thr Phe Asp Cys Pro Ile Lys 
        115                 120                 125


Ile Ile Ala Val His Pro His Phe Val Arg Ser Ser Cys Lys Gln Phe 
    130                 135                 140


Val Thr Gly Gly Lys Lys Leu Leu Leu Phe Glu Arg Ser Trp Met Asn 
145                 150                 155                 160


Arg Trp Lys Ser Ala Val Leu His Glu Gly Glu Gly Asn Ile Arg Ser 
                165                 170                 175


Val Lys Trp Arg Gly His Leu Ile Ala Trp Ala Asn Asn Met Gly Val 
            180                 185                 190


Lys Ile Phe Asp Ile Ile Ser Lys Gln Arg Ile Thr Asn Val Pro Arg 
        195                 200                 205


Asp Asp Ile Ser Leu Arg Pro Asp Met Tyr Pro Cys Ser Leu Cys Trp 
    210                 215                 220


Lys Asp Asn Val Thr Leu Ile Ile Gly Trp Gly Thr Ser Val Lys Val 
225                 230                 235                 240


Cys Ser Val Lys Glu Arg His Ala Ser Glu Met Arg Asp Leu Pro Ser 
                245                 250                 255


Arg Tyr Val Glu Ile Val Ser Gln Phe Glu Thr Glu Phe Tyr Ile Ser 
            260                 265                 270


Gly Leu Ala Pro Leu Cys Asp Gln Leu Val Val Leu Ser Tyr Val Lys 
        275                 280                 285


Glu Ile Ser Glu Lys Thr Glu Arg Glu Tyr Cys Ala Arg Pro Arg Leu 
    290                 295                 300


Asp Ile Ile Gln Pro Leu Ser Glu Thr Cys Glu Glu Ile Ser Ser Asp 
305                 310                 315                 320


Ala Leu Thr Val Arg Gly Phe Gln Glu Asn Glu Cys Arg Asp Tyr His 
                325                 330                 335


Leu Glu Tyr Ser Glu Gly Glu Ser Leu Phe Tyr Ile Val Ser Pro Arg 
            340                 345                 350


Asp Val Val Val Ala Lys Glu Arg Asp Gln Asp Asp His Ile Asp Trp 
        355                 360                 365


Leu Leu Glu Lys Lys Lys Tyr Glu Glu Ala Leu Met Ala Ala Glu Ile 
    370                 375                 380


Ser Gln Lys Asn Ile Lys Arg His Lys Ile Leu Asp Ile Gly Leu Ala 
385                 390                 395                 400


Tyr Ile Asn His Leu Val Glu Arg Gly Asp Tyr Asp Ile Ala Ala Arg 
                405                 410                 415


Lys Cys Gln Lys Ile Leu Gly Lys Asn Ala Ala Leu Trp Glu Tyr Glu 
            420                 425                 430


Val Tyr Lys Phe Lys Glu Ile Gly Gln Leu Lys Ala Ile Ser Pro Tyr 
        435                 440                 445


Leu Pro Arg Gly Asp Pro Val Leu Lys Pro Leu Ile Tyr Glu Met Ile 
    450                 455                 460


Leu His Glu Phe Leu Glu Ser Asp Tyr Glu Gly Phe Ala Thr Leu Ile 
465                 470                 475                 480


Arg Glu Trp Pro Gly Asp Leu Tyr Asn Asn Ser Val Ile Val Gln Ala 
                485                 490                 495


Val Arg Asp His Leu Lys Lys Asp Ser Gln Asn Lys Thr Leu Leu Lys 
            500                 505                 510


Thr Leu Ala Glu Leu Tyr Thr Tyr Asp Lys Asn Tyr Gly Asn Ala Leu 
        515                 520                 525


Glu Ile Tyr Leu Thr Leu Arg His Lys Asp Val Phe Gln Leu Ile His 
    530                 535                 540


Lys His Asn Leu Phe Ser Ser Ile Lys Asp Lys Ile Val Leu Leu Met 
545                 550                 555                 560


Asp Phe Asp Ser Glu Lys Ala Val Asp Met Leu Leu Asp Asn Glu Asp 
                565                 570                 575


Lys Ile Ser Ile Lys Lys Val Val Glu Glu Leu Glu Asp Arg Pro Glu 
            580                 585                 590


Leu Gln His Val Tyr Leu His Lys Leu Phe Lys Arg Asp His His Lys 
        595                 600                 605


Gly Gln Arg Tyr His Glu Lys Gln Ile Ser Leu Tyr Ala Glu Tyr Asp 
    610                 615                 620


Arg Pro Asn Leu Leu Pro Phe Leu Arg Asp Ser Thr His Cys Pro Leu 
625                 630                 635                 640


Glu Lys Ala Leu Glu Ile Cys Gln Gln Arg Asn Phe Val Glu Glu Thr 
                645                 650                 655


Val Tyr Leu Leu Ser Arg Met Gly Asn Ser Arg Ser Ala Leu Lys Met 
            660                 665                 670


Ile Met Glu Glu Leu His Asp Val Asp Lys Ala Ile Glu Phe Ala Lys 
        675                 680                 685


Glu Gln Asp Asp Gly Glu Leu Trp Glu Asp Leu Ile Leu Tyr Ser Ile 
    690                 695                 700


Asp Lys Pro Pro Phe Ile Thr Gly Leu Leu Asn Asn Ile Gly Thr His 
705                 710                 715                 720


Val Asp Pro Ile Leu Leu Ile His Arg Ile Lys Glu Gly Met Glu Ile 
                725                 730                 735


Pro Asn Leu Arg Asp Ser Leu Val Lys Ile Leu Gln Asp Tyr Asn Leu 
            740                 745                 750


Gln Ile Leu Leu Arg Glu Gly Cys Lys Lys Ile Leu Val Ala Asp Ser 
        755                 760                 765


Leu Ser Leu Leu Lys Lys Met His Arg Thr Gln Met Lys Gly Val Leu 
    770                 775                 780


Val Asp Glu Glu Asn Ile Cys Glu Ser Cys Leu Ser Pro Ile Leu Pro 
785                 790                 795                 800


Ser Asp Ala Ala Lys Pro Phe Ser Val Val Val Phe His Cys Arg His 
                805                 810                 815


Met Phe His Lys Glu Cys Leu Pro Met Pro Ser Met Asn Ser Ala Ala 
            820                 825                 830


Gln Phe Cys Asn Ile Cys Ser Ala Lys Asn Arg Gly Pro Gly Ser Ala 
        835                 840                 845


Ile Leu Glu Met Lys Lys 
    850


<210>  3648
<211>  1053
<212>  DNA
<213>  Homo sapiens

<400>  3648
tcgcatagca acatgattat aatacctgtt ttgtgtctga tcataccacc cctcaggaat     60

gcttttgtaa ataagccatt ctctaaaggc accttattgc tgaaaattaa actgcaactc    120

gactttcagt cgggattggt ttaaaatgat cttgcttgtt gcattaagtt ctcctccttt    180

ctctgccctc ctcgccagat gcagctaagc ccttcagcgt ggtggtcttc cattgccggc    240

acatgttcca caaggagtgc ctgcccatgc ccagcatgaa ctctgctgca cagttctgca    300

acatctgcag tgctaagaac cgtggaccag gaagtgcaat tttggagatg aaaaaatagc    360

tcatttctcc ttgtcagtct ccttgtcacc actctttttg agactgtttt tgcaacaaca    420

aaagcatttg ttgacactcg tgctgttaag agatttgttt atgtttatat tatactcaaa    480

aacaatttct tcatctattc ctgtactaat ggtttctctt tgcagttcac agagaatttg    540

gggctctctt catgccttga aattttgggg tccatagtga atattttgtt atttatttgt    600

ttggctcatt ctttatatag taatggaaac ataagtctag gagttagaaa tgaatttttt    660

agaccttagt aaaaccattt aaccataaaa tggacaactg agaattctcc cagctgcctg    720

aaagcgtcgc caactgtggt tatcctgcaa gctgctacct gcaacttgga cgttgtttcc    780

acgtgctctg ctggctacga ttcttgcatt ctgggtttgg cttttttctg tgtcatcaac    840

tatggttatc ctctaaatag gcatttaatg aaacattgta caaattgtca ctcatttgat    900

gacacctggg aataacatta gcaggctgat gtcctgcacc attatgttta ctaatcacat    960

gttctgtgtg ctgtgacgac tgtcaaagag tatctggcca tggcggacac tcagcatttg   1020

ttgattgaat aaatgttagc tcttctcatt gtg                                1053


<210>  3649
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  3649

Met Phe His Lys Glu Cys Leu Pro Met Pro Ser Met Asn Ser Ala Ala 
1               5                   10                  15


Gln Phe Cys Asn Ile Cys Ser Ala Lys Asn Arg Gly Pro Gly Ser Ala 
            20                  25                  30


Ile Leu Glu Met Lys Lys 
        35


<210>  3650
<211>  3201
<212>  DNA
<213>  Homo sapiens

<400>  3650
gactctcccg tggcgccatg gcggaagcag aggagcagga aactgggtcc cttgaagaat     60

ctacagatga gtctgaggaa gaagagagcg aagaggaacc caagctgaag tatgaaaggc    120

tttccaatgg ggtaactgaa atacttcaga aggatgcagc tagctgcatg acagtccatg    180

acaagttttt ggcattgggc acacattatg gcaaggttta tttacttgat gtccagggga    240

acatcactca gaagtttgat gtagtgcagg tatttggact gtattctgga gaagaatttc    300

acgagacttt tgactgtccc attaaaatta ttgctgtgca cccacatttc gtgagatcca    360

gttgcaagca gtttgtgacc ggagggaaga agctgctact gtttgaacgg tcttggatga    420

acagatggaa gtctgctgtt ctgcatgaag gggaagggaa cataaggagt gtgaagtgga    480

gaggccatct gattgcttgg gccaataata tgggtgtgaa gatttttgac atcatctcaa    540

agcaaagaat caccaatgtg ccccgggatg atataagtct tcgcccagac atgtatccct    600

gcagcctctg ctggaaggac aatgtgacac tgattattgg ctgggggact tctgtcaagg    660

tgtgctcagt gaaggaacgg catgccagtg aaatgaggga tttgccaagt cgatatgttg    720

aaatagtgtc tcagtttgaa actgaattct acatcagtgg acttgcacct ctctgtgatc    780

agcttgttgt actttcgtat gtaaaggaga tttcagaaaa aacggaaaga gaatactgtg    840

ccaggcctag actggacatc atccagccac tttctgagac ttgtgaagag atctcttctg    900

atgctttgac agtcagaggc tttcaggaga atgaatgtag agattatcat ttagaatact    960

ctgaagggga atcacttttt tacatcgtga gtccgagaga tgttgtagtg gccaaggaac   1020

gagaccaaga tgatcacatt gactggctcc ttgaaaagaa gaaatatgaa gaagcattga   1080

tggcagctga aattagccaa aaaaatatta aaagacataa gattctggat attggcttgg   1140

catatataaa tcacctggtg gagagaggag actatgacat agcagcacgc aaatgccaga   1200

aaattcttgg gaaaaatgca gcactctggg aatatgaagt ttataaattt aaagaaattg   1260

gacagcttaa ggctattagt ccttatttgc caagaggtga tccagttctg aaaccactca   1320

tctatgaaat gatcttacat gaatttttgg agagtgatta tgagggtttt gccacattga   1380

tccgagaatg gcctggagat ctgtataata attcagtcat agttcaagca gttcgggatc   1440

atttgaagaa agatagtcag aacaagactt tacttaaaac cctggcagaa ttgtacacct   1500

atgacaagaa ctatggcaat gctctggaaa tatacttaac attaagacat aaagacgttt   1560

ttcagttgat ccacaagcat aatcttttca gttctatcaa ggataaaatt gttttattaa   1620

tggattttga ttcagagaaa gctgttgaca tgcttttgga caatgaagat aaaatttcaa   1680

ttaaaaaggt agtggaagaa ttggaagaca gaccagagct acagcatgtg tatttgcata   1740

agcttttcaa gagagaccac cataaggggc agcgttacca tgaaaaacag atcagtcttt   1800

atgctgaata tgatcgacca aacttacttc cctttctccg agacagtacc cattgcccac   1860

ttgaaaaggc tcttgagatc tgtcaacaga gaaactttgt agaagagaca gtttatcttc   1920

tgagccgaat gggtaatagc cgaagtgccc tgaagatgat tatggaggaa ttacatgatg   1980

ttgataaagc aatcgaattt gccaaggagc aagatgatgg agagctgtgg gaagatttga   2040

ttttatattc cattgacaaa ccaccattta ttactggctt gttaaacaac attggcacac   2100

atgttgaccc aattctactg attcaccgta ttaaggaagg aatggagatc cccaatttga   2160

gagattcctt ggttaaaatt ctgcaagact acaatttgca aattctgctt cgtgaaggct   2220

gcaagaagat tctcgtagct gactctttgt ccttactgaa gaaaatgcac cgaactcaaa   2280

tgaaaggtgt tcttgttgat gaggagaaca tctgtgagtc gtgcctttcc cctattcttc   2340

catcagatgc agctaagccc ttcagcgtgg tggtcttcca ttgccggcac atgttccaca   2400

aggagtgcct gcccatgccc agcatgaact ctgctgcaca gttctgcaac atctgcagtg   2460

ctaagaaccg tggaccagga agtgcaattt tggagatgaa aaaatagctc atttctcctt   2520

gtcagtctcc ttgtcaccac tctttttgag actgtttttg caacaacaaa agcatttgtt   2580

gacactcgtg ctgttaagag atttgtttat gtttatatta tactcaaaaa caatttcttc   2640

atctattcct gtactaatgg tttctctttg cagttcacag agaatttggg gctctcttca   2700

tgccttgaaa ttttggggtc catagtgaat attttgttat ttatttgttt ggctcattct   2760

ttatatagta atggaaacat aagtctagga gttagaaatg aattttttag accttagtaa   2820

aaccatttaa ccataaaatg gacaactgag aattctccca gctgcctgaa agcgtcgcca   2880

actgtggtta tcctgcaagc tgctacctgc aacttggacg ttgtttccac gtgctctgct   2940

ggctacgatt cttgcattct gggtttggct tttttctgtg tcatcaacta tggttatcct   3000

ctaaataggc atttaatgaa acattgtaca aattgtcact catttgatga cacctgggaa   3060

taacattagc aggctgatgt cctgcaccat tatgtttact aatcacatgt tctgtgtgct   3120

gtgacgactg tcaaagagta tctggccatg gcggacactc agcatttgtt gattgaataa   3180

atgttagctc ttctcattgt g                                             3201


<210>  3651
<211>  829
<212>  PRT
<213>  Homo sapiens

<400>  3651

Met Ala Glu Ala Glu Glu Gln Glu Thr Gly Ser Leu Glu Glu Ser Thr 
1               5                   10                  15


Asp Glu Ser Glu Glu Glu Glu Ser Glu Glu Glu Pro Lys Leu Lys Tyr 
            20                  25                  30


Glu Arg Leu Ser Asn Gly Val Thr Glu Ile Leu Gln Lys Asp Ala Ala 
        35                  40                  45


Ser Cys Met Thr Val His Asp Lys Phe Leu Ala Leu Gly Thr His Tyr 
    50                  55                  60


Gly Lys Val Tyr Leu Leu Asp Val Gln Gly Asn Ile Thr Gln Lys Phe 
65                  70                  75                  80


Asp Val Val Gln Val Phe Gly Leu Tyr Ser Gly Glu Glu Phe His Glu 
                85                  90                  95


Thr Phe Asp Cys Pro Ile Lys Ile Ile Ala Val His Pro His Phe Val 
            100                 105                 110


Arg Ser Ser Cys Lys Gln Phe Val Thr Gly Gly Lys Lys Leu Leu Leu 
        115                 120                 125


Phe Glu Arg Ser Trp Met Asn Arg Trp Lys Ser Ala Val Leu His Glu 
    130                 135                 140


Gly Glu Gly Asn Ile Arg Ser Val Lys Trp Arg Gly His Leu Ile Ala 
145                 150                 155                 160


Trp Ala Asn Asn Met Gly Val Lys Ile Phe Asp Ile Ile Ser Lys Gln 
                165                 170                 175


Arg Ile Thr Asn Val Pro Arg Asp Asp Ile Ser Leu Arg Pro Asp Met 
            180                 185                 190


Tyr Pro Cys Ser Leu Cys Trp Lys Asp Asn Val Thr Leu Ile Ile Gly 
        195                 200                 205


Trp Gly Thr Ser Val Lys Val Cys Ser Val Lys Glu Arg His Ala Ser 
    210                 215                 220


Glu Met Arg Asp Leu Pro Ser Arg Tyr Val Glu Ile Val Ser Gln Phe 
225                 230                 235                 240


Glu Thr Glu Phe Tyr Ile Ser Gly Leu Ala Pro Leu Cys Asp Gln Leu 
                245                 250                 255


Val Val Leu Ser Tyr Val Lys Glu Ile Ser Glu Lys Thr Glu Arg Glu 
            260                 265                 270


Tyr Cys Ala Arg Pro Arg Leu Asp Ile Ile Gln Pro Leu Ser Glu Thr 
        275                 280                 285


Cys Glu Glu Ile Ser Ser Asp Ala Leu Thr Val Arg Gly Phe Gln Glu 
    290                 295                 300


Asn Glu Cys Arg Asp Tyr His Leu Glu Tyr Ser Glu Gly Glu Ser Leu 
305                 310                 315                 320


Phe Tyr Ile Val Ser Pro Arg Asp Val Val Val Ala Lys Glu Arg Asp 
                325                 330                 335


Gln Asp Asp His Ile Asp Trp Leu Leu Glu Lys Lys Lys Tyr Glu Glu 
            340                 345                 350


Ala Leu Met Ala Ala Glu Ile Ser Gln Lys Asn Ile Lys Arg His Lys 
        355                 360                 365


Ile Leu Asp Ile Gly Leu Ala Tyr Ile Asn His Leu Val Glu Arg Gly 
    370                 375                 380


Asp Tyr Asp Ile Ala Ala Arg Lys Cys Gln Lys Ile Leu Gly Lys Asn 
385                 390                 395                 400


Ala Ala Leu Trp Glu Tyr Glu Val Tyr Lys Phe Lys Glu Ile Gly Gln 
                405                 410                 415


Leu Lys Ala Ile Ser Pro Tyr Leu Pro Arg Gly Asp Pro Val Leu Lys 
            420                 425                 430


Pro Leu Ile Tyr Glu Met Ile Leu His Glu Phe Leu Glu Ser Asp Tyr 
        435                 440                 445


Glu Gly Phe Ala Thr Leu Ile Arg Glu Trp Pro Gly Asp Leu Tyr Asn 
    450                 455                 460


Asn Ser Val Ile Val Gln Ala Val Arg Asp His Leu Lys Lys Asp Ser 
465                 470                 475                 480


Gln Asn Lys Thr Leu Leu Lys Thr Leu Ala Glu Leu Tyr Thr Tyr Asp 
                485                 490                 495


Lys Asn Tyr Gly Asn Ala Leu Glu Ile Tyr Leu Thr Leu Arg His Lys 
            500                 505                 510


Asp Val Phe Gln Leu Ile His Lys His Asn Leu Phe Ser Ser Ile Lys 
        515                 520                 525


Asp Lys Ile Val Leu Leu Met Asp Phe Asp Ser Glu Lys Ala Val Asp 
    530                 535                 540


Met Leu Leu Asp Asn Glu Asp Lys Ile Ser Ile Lys Lys Val Val Glu 
545                 550                 555                 560


Glu Leu Glu Asp Arg Pro Glu Leu Gln His Val Tyr Leu His Lys Leu 
                565                 570                 575


Phe Lys Arg Asp His His Lys Gly Gln Arg Tyr His Glu Lys Gln Ile 
            580                 585                 590


Ser Leu Tyr Ala Glu Tyr Asp Arg Pro Asn Leu Leu Pro Phe Leu Arg 
        595                 600                 605


Asp Ser Thr His Cys Pro Leu Glu Lys Ala Leu Glu Ile Cys Gln Gln 
    610                 615                 620


Arg Asn Phe Val Glu Glu Thr Val Tyr Leu Leu Ser Arg Met Gly Asn 
625                 630                 635                 640


Ser Arg Ser Ala Leu Lys Met Ile Met Glu Glu Leu His Asp Val Asp 
                645                 650                 655


Lys Ala Ile Glu Phe Ala Lys Glu Gln Asp Asp Gly Glu Leu Trp Glu 
            660                 665                 670


Asp Leu Ile Leu Tyr Ser Ile Asp Lys Pro Pro Phe Ile Thr Gly Leu 
        675                 680                 685


Leu Asn Asn Ile Gly Thr His Val Asp Pro Ile Leu Leu Ile His Arg 
    690                 695                 700


Ile Lys Glu Gly Met Glu Ile Pro Asn Leu Arg Asp Ser Leu Val Lys 
705                 710                 715                 720


Ile Leu Gln Asp Tyr Asn Leu Gln Ile Leu Leu Arg Glu Gly Cys Lys 
                725                 730                 735


Lys Ile Leu Val Ala Asp Ser Leu Ser Leu Leu Lys Lys Met His Arg 
            740                 745                 750


Thr Gln Met Lys Gly Val Leu Val Asp Glu Glu Asn Ile Cys Glu Ser 
        755                 760                 765


Cys Leu Ser Pro Ile Leu Pro Ser Asp Ala Ala Lys Pro Phe Ser Val 
    770                 775                 780


Val Val Phe His Cys Arg His Met Phe His Lys Glu Cys Leu Pro Met 
785                 790                 795                 800


Pro Ser Met Asn Ser Ala Ala Gln Phe Cys Asn Ile Cys Ser Ala Lys 
                805                 810                 815


Asn Arg Gly Pro Gly Ser Ala Ile Leu Glu Met Lys Lys 
            820                 825


<210>  3652
<211>  461
<212>  DNA
<213>  Homo sapiens

<400>  3652
ttcaatttaa tttaatttta atcaatttaa acttaaatag acacatagag caagtggctg     60

ctgtcttgga taactcaggt gaggcttcaa actgcaaact cttttgtggt ttgagactag    120

catgttctta agcattctca tgtgcagaag aaaatgggta atggttctgt ctgaaatctt    180

gaatggtatt ttaaagtgtg taagtgaatt tccaagtaca gaattgattc atggatacct    240

tttaataata aattatttta agcagcataa atgcttatca ttagtcagac tatctttctc    300

taaacattct ccttattcag ttgtattaca gtgttctatt tatctgtgaa tggcagtccc    360

actcaactat aaactatctg tatcttaaca cccagaacaa atctagggag atgtgttctt    420

tatttgtttg ctttgtttta tttttaaaga agctgtggaa a                        461


<210>  3653
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  3653

Met Phe Leu Ser Ile Leu Met Cys Arg Arg Lys Trp Val Met Val Leu 
1               5                   10                  15


Ser Glu Ile Leu Asn Gly Ile Leu Lys Cys Val Ser Glu Phe Pro Ser 
            20                  25                  30


Thr Glu Leu Ile His Gly Tyr Leu Leu Ile Ile Asn Tyr Phe Lys Gln 
        35                  40                  45


His Lys Cys Leu Ser Leu Val Arg Leu Ser Phe Ser Lys His Ser Pro 
    50                  55                  60


Tyr Ser Val Val Leu Gln Cys Ser Ile Tyr Leu 
65                  70                  75


<210>  3654
<211>  8237
<212>  DNA
<213>  Homo sapiens

<400>  3654
tgcggttctc ttgctcgctt tctgttctct tgcttacttt caaatgcaga cgtgcactac     60

agcgtcacca gggcattttt ggtcgaagag agctgaagta atgagaagac atcatggagg    120

cccagtccca cagctccacg accactgaaa agaaaaaagt tgagaattcc atagtgaagt    180

gctccactcg aacagatgtg agcgagaaag ccgttgcctc cagcaccact tctaatgagg    240

atgaaagtcc tggacagact tatcacagag agagaagaaa cgcaatcact atgcagccac    300

agaatgtcca ggggctcagc aaagtcagtg aggaaccttc aacatcgagt gacgagaggg    360

cctcattgat caagaaagag atccatgggt ccctgccaca cgtggcggag ccctctgtgc    420

cgtaccgcgg gacggtgttt gccatggacc ccaggaatgg ttacatggag ccccactacc    480

accctcctca tcttttccct gccttccatc ctcctgtacc aattgatgcc agacatcatg    540

agggccgtta ccattacgat ccatctccga ttcctccatt gcatatgact tccgccttat    600

ctagtagccc tacgtatccg gacctgccct tcattaggat ctccccacac cggaacccca    660

ctgctgcttc cgagtctccc ttcagccctc cacatcccta cattaatccc tacatggact    720

atatccgctc cttgcacagc agcccatcgc tctccatgat ctcagcaacc cgtgggctga    780

gccctacaga tgcgccccat gcaggagtca gcccagcaga atactatcat cagatggccc    840

tgctaactgg ccagcgcagc ccctatgcag acattattcc ctcagctgcc accgccggca    900

cgggggccat ccacatggaa tatcttcatg ctatggatag caccagattc tccagcccca    960

ggctgtcagc caggccgagc cgaaaacgta cactgtccat atcaccactc tccgatcata   1020

gctttgacct tcagaccatg ataaggacgt ctcccaactc cttggtcacg attctcaata   1080

attcccgtag cagctcttca gcaagtggct cctatggtca cttatctgca agtgcaatca   1140

gccctgcctt gagcttcacc tactcttccg cgcccgtctc tctccacatg catcagcaga   1200

tcctaagccg acaacagagc ttaggttcag cctttggaca cagccctcca ctcatccacc   1260

ctgccccaac ttttccaaca cagaggccta ttccagggat ccctacggtt ctgaaccccg   1320

tccaggtcag ctccggccct tctgagtcct cacagaacaa gcccacgagt gagtctgcag   1380

tgagcagcac tggtgacccg atgcacaaca agaggtccaa gatcaaaccc gatgaagacc   1440

tccccagccc aggggctcgg gggcagcagg aacagcccga aggaacaacc cttgtcaagg   1500

aggaagggga caaagatgaa agcaaacagg agcctgaagt catctatgag acaaactgcc   1560

actgggaagg ctgcgcgagg gagttcgaca cccaagagca gcttgtgcac catataaata   1620

acgaccatat tcatggagag aagaaggagt tcgtgtgcag gtggctggac tgctcaagag   1680

agcagaaacc cttcaaagcc cagtatatgt tggtagtgca tatgagaaga cacacgggcg   1740

agaagcctca caaatgcact tttgaaggtt gcacaaaggc ctactcgaga ctagaaaact   1800

tgaaaacaca cttgagatct cacactggag agaaaccata cgtctgtgag cacgaaggtt   1860

gcaacaaggc tttctcaaat gcctctgatc gcgccaaaca ccaaaacaga acgcattcca   1920

atgagaaacc atatgtgtgc aaaatcccag gctgcactaa gcgttacaca gacccaagct   1980

ccctccggaa acatgtgaag acagtgcatg gcccagaggc tcatgtcacc aagaagcagc   2040

gaggggacat ccatcctcgg ccgccacccc cgagagattc cggcagccat tcacagtcca   2100

ggtcgcctgg ccgaccgact cagggagccc ttggtgagca gcaggacctc agcaacacta   2160

cctcaaagcg ggaagaatgc ctccaggtga aaaccgtcaa ggcagagaag ccaatgacat   2220

ctcagccaag ccctggtggt cagtcttcat gcagcagcca acagtccccc atcagcaact   2280

attccaacag tgggctcgag cttcctctga ccgatggagg tagtatagga gacctcagtg   2340

ccatcgatga aaccccaatc atggactcaa ccatttccac tgcaaccaca gcccttgctt   2400

tgcaagccag gagaaacccg gcagggacca aatggatgga gcacgtaaaa ctagaaaggc   2460

taaaacaagt gaatggaatg tttccgcgac tgaaccccat tctaccccct aaagcccctg   2520

cggtctctcc tctcatagga aatggcacac agtccaacaa cacctgcagc ttgggtgggc   2580

ccatgacgct tctcccgggc agaagcgacc tctctggggt ggacgtcact atgctgaaca   2640

tgctcaacag aagggacagc agcgccagca ccatcagctc ggcctacctg agcagccgcc   2700

gctcctcagg gatctcgccc tgcttctcca gccgccgctc cagcgaggcg tcacaggccg   2760

agggccggcc gcagaacgtg agcgtggccg actcctacga ccccatctcc accgacgcct   2820

cgcgccgctc cagcgaagcc agccagagcg acggcctgcc cagcctgctc agcctcacgc   2880

ccgcccagca gtaccgcctc aaggccaagt acgcggctgc cacaggaggg ccgccgccga   2940

cgcccctgcc caacatggag aggatgagcc tgaagacgcg cctggcgctg ctcggggatg   3000

ccctcgagcc tggcgtggcc ctgcctccag ttcatgcccc gaggaggtgc agcgacgggg   3060

gagcccacgg ctacgggcgg cgccacctgc agccgcacga tgcgccgggc cacggcgtga   3120

ggagggccag cgacccggtg cggacaggct ccgagggcct ggccctgcct cgtgtgccgc   3180

gcttcagcag cctcagcagc tgcaaccccc cggcgatggc cacgtccgcg gagaagcgca   3240

gtctcgtgct tcagaattac acgcggcccg agggcggcca gtcccgaaac ttccactcgt   3300

ccccctgtcc tcccagcatc accgagaacg tcaccctgga gtccctgacc atggacgctg   3360

atgccaacct gaacgatgag gatttcctgc cggacgacgt ggtgcagtat ttaaattccc   3420

agaaccaagc agggtacgag cagcacttcc ccagcgccct cccggacgac agcaaagtgc   3480

cccacgggcc cggtgacttt gacgcgcccg ggctgccaga cagccacgct ggccagcagt   3540

tccatgccct cgagcagccc tgccccgagg gcagcaaaac cgacctgccc attcagtgga   3600

acgaagtcag ctccggaagc gccgacctgt cctcctccaa gctcaagtgt gggccgcggc   3660

ccgctgtgcc gcagactcgc gcctttgggt tctgcaacgg catggtcgtc cacccgcaga   3720

accccttgag gagcgggcct gctgggggct atcagaccct cggggagaac agcaacccct   3780

acggtggccc agagcacttg atgctccaca acagccccgg aagtggcacc agtggaaacg   3840

ccttccatga acagccctgt aaggccccgc agtatgggaa ctgtctcaac aggcagccag   3900

tggcccctgg tgcactcgac ggtgcctgtg gtgccgggat tcaagcctca aagctgaaga   3960

gcacccccat gcaagggagc gggggccagc tgaatttcgg cctgccggta gcgccaaatg   4020

agtcagctgg cagcatggtg aatggcatgc agaaccagga cccagtggga caggggtacc   4080

tggctcacca gctcctcggc gacagcatgc agcacccggg ggcaggccgc cccggtcagc   4140

agatgcttgg gcagattagt gctacctcac acatcaacat ctaccaaggg ccagagagct   4200

gcctgccagg ggctcacggc atgggcagcc agccgtcaag cttggcagtt gtcaggggct   4260

accagccatg tgccagcttt gggggcagca ggcgccaggc tatgccgagg gacagccttg   4320

ctctgcagtc aggacagctc agtgacacaa gtcagacctg cagggtgaat ggtatcaaga   4380

tggagatgaa agggcagccc catccgctgt gctctaatct gcagaattac tctggtcagt   4440

tctatgacca aaccgtgggc ttcagtcagc aagacacgaa agctggttca ttctctattt   4500

cagacgccag ctgcctgcta caggggacca gcgccaaaaa ctctgagtta ctttccccag   4560

gtgctaatca ggtgacaagc acagtggaca gcctcgacag ccatgacctg gaaggggtac   4620

agattgactt cgatgccatc atagacgatg gggaccactc cagcctgatg tcgggggccc   4680

tgagcccaag tatcattcag aacctttccc atagctcctc ccgcctcacc acgcctcggg   4740

cgtccctccc attcccagcg ctgtccatga gcaccaccaa catggctatc ggggacatga   4800

gttctttgct gacctcccta gcggaagaaa gcaaattcct tgcagttatg caataggctt   4860

taggaaaaaa agactgcaac caacggaaat caataggagt tgaagagatt aaactgactt   4920

tgttttggct gtttttttag ttctgtatgt attttagcaa tctcatctca cctaactgag   4980

atgtgtttca attatattcc ttttatggaa aaggactctg aaaaacccta aagtattcta   5040

gggagaaact gtcttccatt tcagttttga atcagtattg ttacactcaa accaccctct   5100

ttttaaaaaa aaaaaaaaaa actgtaagcc ccgccccctt tttagtaaac cgatgtaaat   5160

ttgtgatgtg catattcttc tttcttttag aagagcagtc aaattaaagg atttgacatg   5220

ttttgctgtt gctcaaagga aataggagtt ggtgtgcttg tgaccaaggg gttacacttc   5280

cagcttttaa aattctcctt tacatgtgct cagtgttttg ttttgtgttt tggtttctgt   5340

tttttatttt aattcccaca ttgggcacaa gaatcagaat atggatagct agtttaagaa   5400

acttttgtgg gtgcactgta gcatagatga cagaatattg atgttccccc catctccaat   5460

tcagttcagg gcattccaca gttaaacaga aatgggaacg tggggctctt ataaatgaaa   5520

tgggcgctca cagttttggt tttcagctct tcatgtctgt aagtgtgctt tgggggaggc   5580

tatgtctgta tggtcgattc tcagttatca catttgcctc tcctcccact accttcatga   5640

acattcagtg ctgtttcgca ctgcagttag agagaaggga cggacagttg gtgacactca   5700

gccacattgc tacttttatc tgttctggta agaagttaga tagatggtag attgaagcaa   5760

ttgggtagaa ttagttgggg gaatatttat gagttgctgt gtttgttgat tagttccatc   5820

tctttcccat tttaactgag aattgattat atatagctct aagtatatag gtatttaaac   5880

aaccccacaa gcggctgtat cagtaacatt tattaattcc actatagtga gggaggattt   5940

ccattctaaa taccttattt tgagggattt ataaaactta gttgtaaaag agaaagccca   6000

catagtggga ataaattgct tcagccattt ttagtatttg agagcactag ggaagatgtt   6060

tagtagctgt gtggatgcct tttttcacac cctgtctatt gaatgctgca tccattcacg   6120

aagttaaatg ttacatgcag ttagtcctta atgtggactg gatctgtact tttgttttgg   6180

attaaaacat ttaaagattt ttgaagtgca gctactcccc acgtgcattt gatacacata   6240

aaagtcatac tgtgtgtgca caaagagtac atggattttc cagcatattg ctttaaaaaa   6300

ttatataaac tgttaaaata ttaacacctc aggctacctg ctgtattctg tcccattgac   6360

ccctggaatt ggatttactg caagtgattg ataattcaat tatgtggctt ttccccttta   6420

atcttgccat ttaaattaca gtagaaagac aaaatcaagt aaaataaagt gttagataat   6480

agaaagagtg ttaagaccag cccacttttc tcatgtttat gttctttcat ttggaccaag   6540

aatctccgca tggaggttga tttgccactg gggactttgg ctaagactat taggtttgct   6600

ttcaactaga tgttcctgag acaagcagag ggacactgca attccccttc catgcctgct   6660

gttctccccc atgtaagtct tctttgaaat taacggatgt gtctcctttg gaacagcccc   6720

ataacaaaag agaactactg atctgagcat aggaaagtag aggctctacc acttttcagt   6780

tgaaaaagca agactttctc tgtgtttctg aaacaaggca taatgttgtc acagaatcag   6840

agatccagtc tcacttttcc acaaatctcc aaatctccag tcttatcttg tgtgctctaa   6900

tggtttggtt caatcccttt ccaactcttg ttttcaaagc atggggcctg agtgttctcc   6960

actcctccta agaaaggagc ttgggtggaa gggaccatgc tgacctcctc catcagaggg   7020

ctcttccagt agtattctcg gatgcaacct ccatttctca gttaccatta tttcctgtat   7080

cagctttgtc cttcctggag ggatgcacag tgatccggcc caccactgtt gttgtcttgt   7140

gcttctgctc tttcctatgg tttcaggtta ttttctgggt ttcccctatt cttcttttat   7200

ttcttttttt ttttatattt gctttccttt ctactgcttt tagatttgca ggagatgcaa   7260

gtttcagctc aatgtttggc ttctctcaat atggaaattt cagaaggaca gaggagagga   7320

gggaggaaga agaaagtata ctcctccaga atttcagtga tctgttgtgg cagtccagtg   7380

gaaggaaggt cttttgaggt cacttagaag catctttttg ggacatcctt ttgggatctc   7440

tgtaggctag gcatctcata tcttgagact cacccccagc ctccaagcct ctctccattt   7500

ctctaaccta tgcattttag agcgagagga ccgcctcact agtgtcacca tcctgccttt   7560

tctaaaacat gcaggctcac acattctact cctgcttaat gtctgtgtta aacgttttct   7620

aaccattttt gttttatttt tctgaaaaag ttaacccctc ccaactcctc acacattggc   7680

tcttcctctt gagccacaaa gttttgattc ttgcgatgta tgtgccttat tttatgttaa   7740

tcttgtcaat gagagggacc agttggtgtt gcccaatcag cactccaagg ctgtgtgtgc   7800

accagccaga gagcgcacgg tggtagcaga gtcgaggctg tcttgtatcc tggtttcatg   7860

tgttgttttg aactgatagg aggatgttct cttctgacaa gttacccttg tgtatcctgc   7920

agacatgtaa aataaaatac aagttcattt ttttcacctt ttttagattt ttttaaaaaa   7980

taaaatgtgt aatccttttt ttaaaagaaa cacatgtaaa tacatttaag tattgtaggc   8040

atagcgttca gatgtgactg gcccaggcgt tcctcggaca agcctgcatt ccccgtgatc   8100

acgcccacct caagcccagg ggctgcagcc cagccacaga tgaactctac ctttgctttc   8160

agaaccactt agtccttttg taacaaagaa aaaaaaatgt ttcttacaat gtcaataaaa   8220

aattctttgt atggaaa                                                  8237


<210>  3655
<211>  1580
<212>  PRT
<213>  Homo sapiens

<400>  3655

Met Glu Ala Gln Ser His Ser Ser Thr Thr Thr Glu Lys Lys Lys Val 
1               5                   10                  15


Glu Asn Ser Ile Val Lys Cys Ser Thr Arg Thr Asp Val Ser Glu Lys 
            20                  25                  30


Ala Val Ala Ser Ser Thr Thr Ser Asn Glu Asp Glu Ser Pro Gly Gln 
        35                  40                  45


Thr Tyr His Arg Glu Arg Arg Asn Ala Ile Thr Met Gln Pro Gln Asn 
    50                  55                  60


Val Gln Gly Leu Ser Lys Val Ser Glu Glu Pro Ser Thr Ser Ser Asp 
65                  70                  75                  80


Glu Arg Ala Ser Leu Ile Lys Lys Glu Ile His Gly Ser Leu Pro His 
                85                  90                  95


Val Ala Glu Pro Ser Val Pro Tyr Arg Gly Thr Val Phe Ala Met Asp 
            100                 105                 110


Pro Arg Asn Gly Tyr Met Glu Pro His Tyr His Pro Pro His Leu Phe 
        115                 120                 125


Pro Ala Phe His Pro Pro Val Pro Ile Asp Ala Arg His His Glu Gly 
    130                 135                 140


Arg Tyr His Tyr Asp Pro Ser Pro Ile Pro Pro Leu His Met Thr Ser 
145                 150                 155                 160


Ala Leu Ser Ser Ser Pro Thr Tyr Pro Asp Leu Pro Phe Ile Arg Ile 
                165                 170                 175


Ser Pro His Arg Asn Pro Thr Ala Ala Ser Glu Ser Pro Phe Ser Pro 
            180                 185                 190


Pro His Pro Tyr Ile Asn Pro Tyr Met Asp Tyr Ile Arg Ser Leu His 
        195                 200                 205


Ser Ser Pro Ser Leu Ser Met Ile Ser Ala Thr Arg Gly Leu Ser Pro 
    210                 215                 220


Thr Asp Ala Pro His Ala Gly Val Ser Pro Ala Glu Tyr Tyr His Gln 
225                 230                 235                 240


Met Ala Leu Leu Thr Gly Gln Arg Ser Pro Tyr Ala Asp Ile Ile Pro 
                245                 250                 255


Ser Ala Ala Thr Ala Gly Thr Gly Ala Ile His Met Glu Tyr Leu His 
            260                 265                 270


Ala Met Asp Ser Thr Arg Phe Ser Ser Pro Arg Leu Ser Ala Arg Pro 
        275                 280                 285


Ser Arg Lys Arg Thr Leu Ser Ile Ser Pro Leu Ser Asp His Ser Phe 
    290                 295                 300


Asp Leu Gln Thr Met Ile Arg Thr Ser Pro Asn Ser Leu Val Thr Ile 
305                 310                 315                 320


Leu Asn Asn Ser Arg Ser Ser Ser Ser Ala Ser Gly Ser Tyr Gly His 
                325                 330                 335


Leu Ser Ala Ser Ala Ile Ser Pro Ala Leu Ser Phe Thr Tyr Ser Ser 
            340                 345                 350


Ala Pro Val Ser Leu His Met His Gln Gln Ile Leu Ser Arg Gln Gln 
        355                 360                 365


Ser Leu Gly Ser Ala Phe Gly His Ser Pro Pro Leu Ile His Pro Ala 
    370                 375                 380


Pro Thr Phe Pro Thr Gln Arg Pro Ile Pro Gly Ile Pro Thr Val Leu 
385                 390                 395                 400


Asn Pro Val Gln Val Ser Ser Gly Pro Ser Glu Ser Ser Gln Asn Lys 
                405                 410                 415


Pro Thr Ser Glu Ser Ala Val Ser Ser Thr Gly Asp Pro Met His Asn 
            420                 425                 430


Lys Arg Ser Lys Ile Lys Pro Asp Glu Asp Leu Pro Ser Pro Gly Ala 
        435                 440                 445


Arg Gly Gln Gln Glu Gln Pro Glu Gly Thr Thr Leu Val Lys Glu Glu 
    450                 455                 460


Gly Asp Lys Asp Glu Ser Lys Gln Glu Pro Glu Val Ile Tyr Glu Thr 
465                 470                 475                 480


Asn Cys His Trp Glu Gly Cys Ala Arg Glu Phe Asp Thr Gln Glu Gln 
                485                 490                 495


Leu Val His His Ile Asn Asn Asp His Ile His Gly Glu Lys Lys Glu 
            500                 505                 510


Phe Val Cys Arg Trp Leu Asp Cys Ser Arg Glu Gln Lys Pro Phe Lys 
        515                 520                 525


Ala Gln Tyr Met Leu Val Val His Met Arg Arg His Thr Gly Glu Lys 
    530                 535                 540


Pro His Lys Cys Thr Phe Glu Gly Cys Thr Lys Ala Tyr Ser Arg Leu 
545                 550                 555                 560


Glu Asn Leu Lys Thr His Leu Arg Ser His Thr Gly Glu Lys Pro Tyr 
                565                 570                 575


Val Cys Glu His Glu Gly Cys Asn Lys Ala Phe Ser Asn Ala Ser Asp 
            580                 585                 590


Arg Ala Lys His Gln Asn Arg Thr His Ser Asn Glu Lys Pro Tyr Val 
        595                 600                 605


Cys Lys Ile Pro Gly Cys Thr Lys Arg Tyr Thr Asp Pro Ser Ser Leu 
    610                 615                 620


Arg Lys His Val Lys Thr Val His Gly Pro Glu Ala His Val Thr Lys 
625                 630                 635                 640


Lys Gln Arg Gly Asp Ile His Pro Arg Pro Pro Pro Pro Arg Asp Ser 
                645                 650                 655


Gly Ser His Ser Gln Ser Arg Ser Pro Gly Arg Pro Thr Gln Gly Ala 
            660                 665                 670


Leu Gly Glu Gln Gln Asp Leu Ser Asn Thr Thr Ser Lys Arg Glu Glu 
        675                 680                 685


Cys Leu Gln Val Lys Thr Val Lys Ala Glu Lys Pro Met Thr Ser Gln 
    690                 695                 700


Pro Ser Pro Gly Gly Gln Ser Ser Cys Ser Ser Gln Gln Ser Pro Ile 
705                 710                 715                 720


Ser Asn Tyr Ser Asn Ser Gly Leu Glu Leu Pro Leu Thr Asp Gly Gly 
                725                 730                 735


Ser Ile Gly Asp Leu Ser Ala Ile Asp Glu Thr Pro Ile Met Asp Ser 
            740                 745                 750


Thr Ile Ser Thr Ala Thr Thr Ala Leu Ala Leu Gln Ala Arg Arg Asn 
        755                 760                 765


Pro Ala Gly Thr Lys Trp Met Glu His Val Lys Leu Glu Arg Leu Lys 
    770                 775                 780


Gln Val Asn Gly Met Phe Pro Arg Leu Asn Pro Ile Leu Pro Pro Lys 
785                 790                 795                 800


Ala Pro Ala Val Ser Pro Leu Ile Gly Asn Gly Thr Gln Ser Asn Asn 
                805                 810                 815


Thr Cys Ser Leu Gly Gly Pro Met Thr Leu Leu Pro Gly Arg Ser Asp 
            820                 825                 830


Leu Ser Gly Val Asp Val Thr Met Leu Asn Met Leu Asn Arg Arg Asp 
        835                 840                 845


Ser Ser Ala Ser Thr Ile Ser Ser Ala Tyr Leu Ser Ser Arg Arg Ser 
    850                 855                 860


Ser Gly Ile Ser Pro Cys Phe Ser Ser Arg Arg Ser Ser Glu Ala Ser 
865                 870                 875                 880


Gln Ala Glu Gly Arg Pro Gln Asn Val Ser Val Ala Asp Ser Tyr Asp 
                885                 890                 895


Pro Ile Ser Thr Asp Ala Ser Arg Arg Ser Ser Glu Ala Ser Gln Ser 
            900                 905                 910


Asp Gly Leu Pro Ser Leu Leu Ser Leu Thr Pro Ala Gln Gln Tyr Arg 
        915                 920                 925


Leu Lys Ala Lys Tyr Ala Ala Ala Thr Gly Gly Pro Pro Pro Thr Pro 
    930                 935                 940


Leu Pro Asn Met Glu Arg Met Ser Leu Lys Thr Arg Leu Ala Leu Leu 
945                 950                 955                 960


Gly Asp Ala Leu Glu Pro Gly Val Ala Leu Pro Pro Val His Ala Pro 
                965                 970                 975


Arg Arg Cys Ser Asp Gly Gly Ala His Gly Tyr Gly Arg Arg His Leu 
            980                 985                 990


Gln Pro His Asp Ala Pro Gly His Gly Val Arg Arg Ala Ser Asp Pro 
        995                 1000                1005


Val Arg Thr Gly Ser Glu Gly Leu Ala Leu Pro Arg Val Pro Arg Phe 
    1010                1015                1020


Ser Ser Leu Ser Ser Cys Asn Pro Pro Ala Met Ala Thr Ser Ala Glu 
1025                1030                1035                1040


Lys Arg Ser Leu Val Leu Gln Asn Tyr Thr Arg Pro Glu Gly Gly Gln 
                1045                1050                1055


Ser Arg Asn Phe His Ser Ser Pro Cys Pro Pro Ser Ile Thr Glu Asn 
            1060                1065                1070


Val Thr Leu Glu Ser Leu Thr Met Asp Ala Asp Ala Asn Leu Asn Asp 
        1075                1080                1085


Glu Asp Phe Leu Pro Asp Asp Val Val Gln Tyr Leu Asn Ser Gln Asn 
    1090                1095                1100


Gln Ala Gly Tyr Glu Gln His Phe Pro Ser Ala Leu Pro Asp Asp Ser 
1105                1110                1115                1120


Lys Val Pro His Gly Pro Gly Asp Phe Asp Ala Pro Gly Leu Pro Asp 
                1125                1130                1135


Ser His Ala Gly Gln Gln Phe His Ala Leu Glu Gln Pro Cys Pro Glu 
            1140                1145                1150


Gly Ser Lys Thr Asp Leu Pro Ile Gln Trp Asn Glu Val Ser Ser Gly 
        1155                1160                1165


Ser Ala Asp Leu Ser Ser Ser Lys Leu Lys Cys Gly Pro Arg Pro Ala 
    1170                1175                1180


Val Pro Gln Thr Arg Ala Phe Gly Phe Cys Asn Gly Met Val Val His 
1185                1190                1195                1200


Pro Gln Asn Pro Leu Arg Ser Gly Pro Ala Gly Gly Tyr Gln Thr Leu 
                1205                1210                1215


Gly Glu Asn Ser Asn Pro Tyr Gly Gly Pro Glu His Leu Met Leu His 
            1220                1225                1230


Asn Ser Pro Gly Ser Gly Thr Ser Gly Asn Ala Phe His Glu Gln Pro 
        1235                1240                1245


Cys Lys Ala Pro Gln Tyr Gly Asn Cys Leu Asn Arg Gln Pro Val Ala 
    1250                1255                1260


Pro Gly Ala Leu Asp Gly Ala Cys Gly Ala Gly Ile Gln Ala Ser Lys 
1265                1270                1275                1280


Leu Lys Ser Thr Pro Met Gln Gly Ser Gly Gly Gln Leu Asn Phe Gly 
                1285                1290                1295


Leu Pro Val Ala Pro Asn Glu Ser Ala Gly Ser Met Val Asn Gly Met 
            1300                1305                1310


Gln Asn Gln Asp Pro Val Gly Gln Gly Tyr Leu Ala His Gln Leu Leu 
        1315                1320                1325


Gly Asp Ser Met Gln His Pro Gly Ala Gly Arg Pro Gly Gln Gln Met 
    1330                1335                1340


Leu Gly Gln Ile Ser Ala Thr Ser His Ile Asn Ile Tyr Gln Gly Pro 
1345                1350                1355                1360


Glu Ser Cys Leu Pro Gly Ala His Gly Met Gly Ser Gln Pro Ser Ser 
                1365                1370                1375


Leu Ala Val Val Arg Gly Tyr Gln Pro Cys Ala Ser Phe Gly Gly Ser 
            1380                1385                1390


Arg Arg Gln Ala Met Pro Arg Asp Ser Leu Ala Leu Gln Ser Gly Gln 
        1395                1400                1405


Leu Ser Asp Thr Ser Gln Thr Cys Arg Val Asn Gly Ile Lys Met Glu 
    1410                1415                1420


Met Lys Gly Gln Pro His Pro Leu Cys Ser Asn Leu Gln Asn Tyr Ser 
1425                1430                1435                1440


Gly Gln Phe Tyr Asp Gln Thr Val Gly Phe Ser Gln Gln Asp Thr Lys 
                1445                1450                1455


Ala Gly Ser Phe Ser Ile Ser Asp Ala Ser Cys Leu Leu Gln Gly Thr 
            1460                1465                1470


Ser Ala Lys Asn Ser Glu Leu Leu Ser Pro Gly Ala Asn Gln Val Thr 
        1475                1480                1485


Ser Thr Val Asp Ser Leu Asp Ser His Asp Leu Glu Gly Val Gln Ile 
    1490                1495                1500


Asp Phe Asp Ala Ile Ile Asp Asp Gly Asp His Ser Ser Leu Met Ser 
1505                1510                1515                1520


Gly Ala Leu Ser Pro Ser Ile Ile Gln Asn Leu Ser His Ser Ser Ser 
                1525                1530                1535


Arg Leu Thr Thr Pro Arg Ala Ser Leu Pro Phe Pro Ala Leu Ser Met 
            1540                1545                1550


Ser Thr Thr Asn Met Ala Ile Gly Asp Met Ser Ser Leu Leu Thr Ser 
        1555                1560                1565


Leu Ala Glu Glu Ser Lys Phe Leu Ala Val Met Gln 
    1570                1575                1580


<210>  3656
<211>  8209
<212>  DNA
<213>  Homo sapiens

<400>  3656
gtctatggga agttcgggga cttgacagcc gctgccgccg cagggcattt ttggtcgaag     60

agagctgaag taatgagaag acatcatgga ggcccagtcc cacagctcca cgaccactga    120

aaagaaaaaa gttgagaatt ccatagtgaa gtgctccact cgaacagatg tgagcgagaa    180

agccgttgcc tccagcacca cttctaatga ggatgaaagt cctggacaga cttatcacag    240

agagagaaga aacgcaatca ctatgcagcc acagaatgtc caggggctca gcaaagtcag    300

tgaggaacct tcaacatcga gtgacgagag ggcctcattg atcaagaaag agatccatgg    360

gtccctgcca cacgtggcgg agccctctgt gccgtaccgc gggacggtgt ttgccatgga    420

ccccaggaat ggttacatgg agccccacta ccaccctcct catcttttcc ctgccttcca    480

tcctcctgta ccaattgatg ccagacatca tgagggccgt taccattacg atccatctcc    540

gattcctcca ttgcatatga cttccgcctt atctagtagc cctacgtatc cggacctgcc    600

cttcattagg atctccccac accggaaccc cactgctgct tccgagtctc ccttcagccc    660

tccacatccc tacattaatc cctacatgga ctatatccgc tccttgcaca gcagcccatc    720

gctctccatg atctcagcaa cccgtgggct gagccctaca gatgcgcccc atgcaggagt    780

cagcccagca gaatactatc atcagatggc cctgctaact ggccagcgca gcccctatgc    840

agacattatt ccctcagctg ccaccgccgg cacgggggcc atccacatgg aatatcttca    900

tgctatggat agcaccagat tctccagccc caggctgtca gccaggccga gccgaaaacg    960

tacactgtcc atatcaccac tctccgatca tagctttgac cttcagacca tgataaggac   1020

gtctcccaac tccttggtca cgattctcaa taattcccgt agcagctctt cagcaagtgg   1080

ctcctatggt cacttatctg caagtgcaat cagccctgcc ttgagcttca cctactcttc   1140

cgcgcccgtc tctctccaca tgcatcagca gatcctaagc cgacaacaga gcttaggttc   1200

agcctttgga cacagccctc cactcatcca ccctgcccca acttttccaa cacagaggcc   1260

tattccaggg atccctacgg ttctgaaccc cgtccaggtc agctccggcc cttctgagtc   1320

ctcacagaac aagcccacga gtgagtctgc agtgagcagc actggtgacc cgatgcacaa   1380

caagaggtcc aagatcaaac ccgatgaaga cctccccagc ccaggggctc gggggcagca   1440

ggaacagccc gaaggaacaa cccttgtcaa ggaggaaggg gacaaagatg aaagcaaaca   1500

ggagcctgaa gtcatctatg agacaaactg ccactgggaa ggctgcgcga gggagttcga   1560

cacccaagag cagcttgtgc accatataaa taacgaccat attcatggag agaagaagga   1620

gttcgtgtgc aggtggctgg actgctcaag agagcagaaa cccttcaaag cccagtatat   1680

gttggtagtg catatgagaa gacacacggg cgagaagcct cacaaatgca cttttgaagg   1740

ttgcacaaag gcctactcga gactagaaaa cttgaaaaca cacttgagat ctcacactgg   1800

agagaaacca tacgtctgtg agcacgaagg ttgcaacaag gctttctcaa atgcctctga   1860

tcgcgccaaa caccaaaaca gaacgcattc caatgagaaa ccatatgtgt gcaaaatccc   1920

aggctgcact aagcgttaca cagacccaag ctccctccgg aaacatgtga agacagtgca   1980

tggcccagag gctcatgtca ccaagaagca gcgaggggac atccatcctc ggccgccacc   2040

cccgagagat tccggcagcc attcacagtc caggtcgcct ggccgaccga ctcagggagc   2100

ccttggtgag cagcaggacc tcagcaacac tacctcaaag cgggaagaat gcctccaggt   2160

gaaaaccgtc aaggcagaga agccaatgac atctcagcca agccctggtg gtcagtcttc   2220

atgcagcagc caacagtccc ccatcagcaa ctattccaac agtgggctcg agcttcctct   2280

gaccgatgga ggtagtatag gagacctcag tgccatcgat gaaaccccaa tcatggactc   2340

aaccatttcc actgcaacca cagcccttgc tttgcaagcc aggagaaacc cggcagggac   2400

caaatggatg gagcacgtaa aactagaaag gctaaaacaa gtgaatggaa tgtttccgcg   2460

actgaacccc attctacccc ctaaagcccc tgcggtctct cctctcatag gaaatggcac   2520

acagtccaac aacacctgca gcttgggtgg gcccatgacg cttctcccgg gcagaagcga   2580

cctctctggg gtggacgtca ctatgctgaa catgctcaac agaagggaca gcagcgccag   2640

caccatcagc tcggcctacc tgagcagccg ccgctcctca gggatctcgc cctgcttctc   2700

cagccgccgc tccagcgagg cgtcacaggc cgagggccgg ccgcagaacg tgagcgtggc   2760

cgactcctac gaccccatct ccaccgacgc ctcgcgccgc tccagcgaag ccagccagag   2820

cgacggcctg cccagcctgc tcagcctcac gcccgcccag cagtaccgcc tcaaggccaa   2880

gtacgcggct gccacaggag ggccgccgcc gacgcccctg cccaacatgg agaggatgag   2940

cctgaagacg cgcctggcgc tgctcgggga tgccctcgag cctggcgtgg ccctgcctcc   3000

agttcatgcc ccgaggaggt gcagcgacgg gggagcccac ggctacgggc ggcgccacct   3060

gcagccgcac gatgcgccgg gccacggcgt gaggagggcc agcgacccgg tgcggacagg   3120

ctccgagggc ctggccctgc ctcgtgtgcc gcgcttcagc agcctcagca gctgcaaccc   3180

cccggcgatg gccacgtccg cggagaagcg cagtctcgtg cttcagaatt acacgcggcc   3240

cgagggcggc cagtcccgaa acttccactc gtccccctgt cctcccagca tcaccgagaa   3300

cgtcaccctg gagtccctga ccatggacgc tgatgccaac ctgaacgatg aggatttcct   3360

gccggacgac gtggtgcagt atttaaattc ccagaaccaa gcagggtacg agcagcactt   3420

ccccagcgcc ctcccggacg acagcaaagt gccccacggg cccggtgact ttgacgcgcc   3480

cgggctgcca gacagccacg ctggccagca gttccatgcc ctcgagcagc cctgccccga   3540

gggcagcaaa accgacctgc ccattcagtg gaacgaagtc agctccggaa gcgccgacct   3600

gtcctcctcc aagctcaagt gtgggccgcg gcccgctgtg ccgcagactc gcgcctttgg   3660

gttctgcaac ggcatggtcg tccacccgca gaaccccttg aggagcgggc ctgctggggg   3720

ctatcagacc ctcggggaga acagcaaccc ctacggtggc ccagagcact tgatgctcca   3780

caacagcccc ggaagtggca ccagtggaaa cgccttccat gaacagccct gtaaggcccc   3840

gcagtatggg aactgtctca acaggcagcc agtggcccct ggtgcactcg acggtgcctg   3900

tggtgccggg attcaagcct caaagctgaa gagcaccccc atgcaaggga gcgggggcca   3960

gctgaatttc ggcctgccgg tagcgccaaa tgagtcagct ggcagcatgg tgaatggcat   4020

gcagaaccag gacccagtgg gacaggggta cctggctcac cagctcctcg gcgacagcat   4080

gcagcacccg ggggcaggcc gccccggtca gcagatgctt gggcagatta gtgctacctc   4140

acacatcaac atctaccaag ggccagagag ctgcctgcca ggggctcacg gcatgggcag   4200

ccagccgtca agcttggcag ttgtcagggg ctaccagcca tgtgccagct ttgggggcag   4260

caggcgccag gctatgccga gggacagcct tgctctgcag tcaggacagc tcagtgacac   4320

aagtcagacc tgcagggtga atggtatcaa gatggagatg aaagggcagc cccatccgct   4380

gtgctctaat ctgcagaatt actctggtca gttctatgac caaaccgtgg gcttcagtca   4440

gcaagacacg aaagctggtt cattctctat ttcagacgcc agctgcctgc tacaggggac   4500

cagcgccaaa aactctgagt tactttcccc aggtgctaat caggtgacaa gcacagtgga   4560

cagcctcgac agccatgacc tggaaggggt acagattgac ttcgatgcca tcatagacga   4620

tggggaccac tccagcctga tgtcgggggc cctgagccca agtatcattc agaacctttc   4680

ccatagctcc tcccgcctca ccacgcctcg ggcgtccctc ccattcccag cgctgtccat   4740

gagcaccacc aacatggcta tcggggacat gagttctttg ctgacctccc tagcggaaga   4800

aagcaaattc cttgcagtta tgcaataggc tttaggaaaa aaagactgca accaacggaa   4860

atcaatagga gttgaagaga ttaaactgac tttgttttgg ctgttttttt agttctgtat   4920

gtattttagc aatctcatct cacctaactg agatgtgttt caattatatt ccttttatgg   4980

aaaaggactc tgaaaaaccc taaagtattc tagggagaaa ctgtcttcca tttcagtttt   5040

gaatcagtat tgttacactc aaaccaccct ctttttaaaa aaaaaaaaaa aaactgtaag   5100

ccccgccccc tttttagtaa accgatgtaa atttgtgatg tgcatattct tctttctttt   5160

agaagagcag tcaaattaaa ggatttgaca tgttttgctg ttgctcaaag gaaataggag   5220

ttggtgtgct tgtgaccaag gggttacact tccagctttt aaaattctcc tttacatgtg   5280

ctcagtgttt tgttttgtgt tttggtttct gttttttatt ttaattccca cattgggcac   5340

aagaatcaga atatggatag ctagtttaag aaacttttgt gggtgcactg tagcatagat   5400

gacagaatat tgatgttccc cccatctcca attcagttca gggcattcca cagttaaaca   5460

gaaatgggaa cgtggggctc ttataaatga aatgggcgct cacagttttg gttttcagct   5520

cttcatgtct gtaagtgtgc tttgggggag gctatgtctg tatggtcgat tctcagttat   5580

cacatttgcc tctcctccca ctaccttcat gaacattcag tgctgtttcg cactgcagtt   5640

agagagaagg gacggacagt tggtgacact cagccacatt gctactttta tctgttctgg   5700

taagaagtta gatagatggt agattgaagc aattgggtag aattagttgg gggaatattt   5760

atgagttgct gtgtttgttg attagttcca tctctttccc attttaactg agaattgatt   5820

atatatagct ctaagtatat aggtatttaa acaaccccac aagcggctgt atcagtaaca   5880

tttattaatt ccactatagt gagggaggat ttccattcta aataccttat tttgagggat   5940

ttataaaact tagttgtaaa agagaaagcc cacatagtgg gaataaattg cttcagccat   6000

ttttagtatt tgagagcact agggaagatg tttagtagct gtgtggatgc cttttttcac   6060

accctgtcta ttgaatgctg catccattca cgaagttaaa tgttacatgc agttagtcct   6120

taatgtggac tggatctgta cttttgtttt ggattaaaac atttaaagat ttttgaagtg   6180

cagctactcc ccacgtgcat ttgatacaca taaaagtcat actgtgtgtg cacaaagagt   6240

acatggattt tccagcatat tgctttaaaa aattatataa actgttaaaa tattaacacc   6300

tcaggctacc tgctgtattc tgtcccattg acccctggaa ttggatttac tgcaagtgat   6360

tgataattca attatgtggc ttttcccctt taatcttgcc atttaaatta cagtagaaag   6420

acaaaatcaa gtaaaataaa gtgttagata atagaaagag tgttaagacc agcccacttt   6480

tctcatgttt atgttctttc atttggacca agaatctccg catggaggtt gatttgccac   6540

tggggacttt ggctaagact attaggtttg ctttcaacta gatgttcctg agacaagcag   6600

agggacactg caattcccct tccatgcctg ctgttctccc ccatgtaagt cttctttgaa   6660

attaacggat gtgtctcctt tggaacagcc ccataacaaa agagaactac tgatctgagc   6720

ataggaaagt agaggctcta ccacttttca gttgaaaaag caagactttc tctgtgtttc   6780

tgaaacaagg cataatgttg tcacagaatc agagatccag tctcactttt ccacaaatct   6840

ccaaatctcc agtcttatct tgtgtgctct aatggtttgg ttcaatccct ttccaactct   6900

tgttttcaaa gcatggggcc tgagtgttct ccactcctcc taagaaagga gcttgggtgg   6960

aagggaccat gctgacctcc tccatcagag ggctcttcca gtagtattct cggatgcaac   7020

ctccatttct cagttaccat tatttcctgt atcagctttg tccttcctgg agggatgcac   7080

agtgatccgg cccaccactg ttgttgtctt gtgcttctgc tctttcctat ggtttcaggt   7140

tattttctgg gtttccccta ttcttctttt atttcttttt ttttttatat ttgctttcct   7200

ttctactgct tttagatttg caggagatgc aagtttcagc tcaatgtttg gcttctctca   7260

atatggaaat ttcagaagga cagaggagag gagggaggaa gaagaaagta tactcctcca   7320

gaatttcagt gatctgttgt ggcagtccag tggaaggaag gtcttttgag gtcacttaga   7380

agcatctttt tgggacatcc ttttgggatc tctgtaggct aggcatctca tatcttgaga   7440

ctcaccccca gcctccaagc ctctctccat ttctctaacc tatgcatttt agagcgagag   7500

gaccgcctca ctagtgtcac catcctgcct tttctaaaac atgcaggctc acacattcta   7560

ctcctgctta atgtctgtgt taaacgtttt ctaaccattt ttgttttatt tttctgaaaa   7620

agttaacccc tcccaactcc tcacacattg gctcttcctc ttgagccaca aagttttgat   7680

tcttgcgatg tatgtgcctt attttatgtt aatcttgtca atgagaggga ccagttggtg   7740

ttgcccaatc agcactccaa ggctgtgtgt gcaccagcca gagagcgcac ggtggtagca   7800

gagtcgaggc tgtcttgtat cctggtttca tgtgttgttt tgaactgata ggaggatgtt   7860

ctcttctgac aagttaccct tgtgtatcct gcagacatgt aaaataaaat acaagttcat   7920

ttttttcacc ttttttagat ttttttaaaa aataaaatgt gtaatccttt ttttaaaaga   7980

aacacatgta aatacattta agtattgtag gcatagcgtt cagatgtgac tggcccaggc   8040

gttcctcgga caagcctgca ttccccgtga tcacgcccac ctcaagccca ggggctgcag   8100

cccagccaca gatgaactct acctttgctt tcagaaccac ttagtccttt tgtaacaaag   8160

aaaaaaaaat gtttcttaca atgtcaataa aaaattcttt gtatggaaa               8209


<210>  3657
<211>  1580
<212>  PRT
<213>  Homo sapiens

<400>  3657

Met Glu Ala Gln Ser His Ser Ser Thr Thr Thr Glu Lys Lys Lys Val 
1               5                   10                  15


Glu Asn Ser Ile Val Lys Cys Ser Thr Arg Thr Asp Val Ser Glu Lys 
            20                  25                  30


Ala Val Ala Ser Ser Thr Thr Ser Asn Glu Asp Glu Ser Pro Gly Gln 
        35                  40                  45


Thr Tyr His Arg Glu Arg Arg Asn Ala Ile Thr Met Gln Pro Gln Asn 
    50                  55                  60


Val Gln Gly Leu Ser Lys Val Ser Glu Glu Pro Ser Thr Ser Ser Asp 
65                  70                  75                  80


Glu Arg Ala Ser Leu Ile Lys Lys Glu Ile His Gly Ser Leu Pro His 
                85                  90                  95


Val Ala Glu Pro Ser Val Pro Tyr Arg Gly Thr Val Phe Ala Met Asp 
            100                 105                 110


Pro Arg Asn Gly Tyr Met Glu Pro His Tyr His Pro Pro His Leu Phe 
        115                 120                 125


Pro Ala Phe His Pro Pro Val Pro Ile Asp Ala Arg His His Glu Gly 
    130                 135                 140


Arg Tyr His Tyr Asp Pro Ser Pro Ile Pro Pro Leu His Met Thr Ser 
145                 150                 155                 160


Ala Leu Ser Ser Ser Pro Thr Tyr Pro Asp Leu Pro Phe Ile Arg Ile 
                165                 170                 175


Ser Pro His Arg Asn Pro Thr Ala Ala Ser Glu Ser Pro Phe Ser Pro 
            180                 185                 190


Pro His Pro Tyr Ile Asn Pro Tyr Met Asp Tyr Ile Arg Ser Leu His 
        195                 200                 205


Ser Ser Pro Ser Leu Ser Met Ile Ser Ala Thr Arg Gly Leu Ser Pro 
    210                 215                 220


Thr Asp Ala Pro His Ala Gly Val Ser Pro Ala Glu Tyr Tyr His Gln 
225                 230                 235                 240


Met Ala Leu Leu Thr Gly Gln Arg Ser Pro Tyr Ala Asp Ile Ile Pro 
                245                 250                 255


Ser Ala Ala Thr Ala Gly Thr Gly Ala Ile His Met Glu Tyr Leu His 
            260                 265                 270


Ala Met Asp Ser Thr Arg Phe Ser Ser Pro Arg Leu Ser Ala Arg Pro 
        275                 280                 285


Ser Arg Lys Arg Thr Leu Ser Ile Ser Pro Leu Ser Asp His Ser Phe 
    290                 295                 300


Asp Leu Gln Thr Met Ile Arg Thr Ser Pro Asn Ser Leu Val Thr Ile 
305                 310                 315                 320


Leu Asn Asn Ser Arg Ser Ser Ser Ser Ala Ser Gly Ser Tyr Gly His 
                325                 330                 335


Leu Ser Ala Ser Ala Ile Ser Pro Ala Leu Ser Phe Thr Tyr Ser Ser 
            340                 345                 350


Ala Pro Val Ser Leu His Met His Gln Gln Ile Leu Ser Arg Gln Gln 
        355                 360                 365


Ser Leu Gly Ser Ala Phe Gly His Ser Pro Pro Leu Ile His Pro Ala 
    370                 375                 380


Pro Thr Phe Pro Thr Gln Arg Pro Ile Pro Gly Ile Pro Thr Val Leu 
385                 390                 395                 400


Asn Pro Val Gln Val Ser Ser Gly Pro Ser Glu Ser Ser Gln Asn Lys 
                405                 410                 415


Pro Thr Ser Glu Ser Ala Val Ser Ser Thr Gly Asp Pro Met His Asn 
            420                 425                 430


Lys Arg Ser Lys Ile Lys Pro Asp Glu Asp Leu Pro Ser Pro Gly Ala 
        435                 440                 445


Arg Gly Gln Gln Glu Gln Pro Glu Gly Thr Thr Leu Val Lys Glu Glu 
    450                 455                 460


Gly Asp Lys Asp Glu Ser Lys Gln Glu Pro Glu Val Ile Tyr Glu Thr 
465                 470                 475                 480


Asn Cys His Trp Glu Gly Cys Ala Arg Glu Phe Asp Thr Gln Glu Gln 
                485                 490                 495


Leu Val His His Ile Asn Asn Asp His Ile His Gly Glu Lys Lys Glu 
            500                 505                 510


Phe Val Cys Arg Trp Leu Asp Cys Ser Arg Glu Gln Lys Pro Phe Lys 
        515                 520                 525


Ala Gln Tyr Met Leu Val Val His Met Arg Arg His Thr Gly Glu Lys 
    530                 535                 540


Pro His Lys Cys Thr Phe Glu Gly Cys Thr Lys Ala Tyr Ser Arg Leu 
545                 550                 555                 560


Glu Asn Leu Lys Thr His Leu Arg Ser His Thr Gly Glu Lys Pro Tyr 
                565                 570                 575


Val Cys Glu His Glu Gly Cys Asn Lys Ala Phe Ser Asn Ala Ser Asp 
            580                 585                 590


Arg Ala Lys His Gln Asn Arg Thr His Ser Asn Glu Lys Pro Tyr Val 
        595                 600                 605


Cys Lys Ile Pro Gly Cys Thr Lys Arg Tyr Thr Asp Pro Ser Ser Leu 
    610                 615                 620


Arg Lys His Val Lys Thr Val His Gly Pro Glu Ala His Val Thr Lys 
625                 630                 635                 640


Lys Gln Arg Gly Asp Ile His Pro Arg Pro Pro Pro Pro Arg Asp Ser 
                645                 650                 655


Gly Ser His Ser Gln Ser Arg Ser Pro Gly Arg Pro Thr Gln Gly Ala 
            660                 665                 670


Leu Gly Glu Gln Gln Asp Leu Ser Asn Thr Thr Ser Lys Arg Glu Glu 
        675                 680                 685


Cys Leu Gln Val Lys Thr Val Lys Ala Glu Lys Pro Met Thr Ser Gln 
    690                 695                 700


Pro Ser Pro Gly Gly Gln Ser Ser Cys Ser Ser Gln Gln Ser Pro Ile 
705                 710                 715                 720


Ser Asn Tyr Ser Asn Ser Gly Leu Glu Leu Pro Leu Thr Asp Gly Gly 
                725                 730                 735


Ser Ile Gly Asp Leu Ser Ala Ile Asp Glu Thr Pro Ile Met Asp Ser 
            740                 745                 750


Thr Ile Ser Thr Ala Thr Thr Ala Leu Ala Leu Gln Ala Arg Arg Asn 
        755                 760                 765


Pro Ala Gly Thr Lys Trp Met Glu His Val Lys Leu Glu Arg Leu Lys 
    770                 775                 780


Gln Val Asn Gly Met Phe Pro Arg Leu Asn Pro Ile Leu Pro Pro Lys 
785                 790                 795                 800


Ala Pro Ala Val Ser Pro Leu Ile Gly Asn Gly Thr Gln Ser Asn Asn 
                805                 810                 815


Thr Cys Ser Leu Gly Gly Pro Met Thr Leu Leu Pro Gly Arg Ser Asp 
            820                 825                 830


Leu Ser Gly Val Asp Val Thr Met Leu Asn Met Leu Asn Arg Arg Asp 
        835                 840                 845


Ser Ser Ala Ser Thr Ile Ser Ser Ala Tyr Leu Ser Ser Arg Arg Ser 
    850                 855                 860


Ser Gly Ile Ser Pro Cys Phe Ser Ser Arg Arg Ser Ser Glu Ala Ser 
865                 870                 875                 880


Gln Ala Glu Gly Arg Pro Gln Asn Val Ser Val Ala Asp Ser Tyr Asp 
                885                 890                 895


Pro Ile Ser Thr Asp Ala Ser Arg Arg Ser Ser Glu Ala Ser Gln Ser 
            900                 905                 910


Asp Gly Leu Pro Ser Leu Leu Ser Leu Thr Pro Ala Gln Gln Tyr Arg 
        915                 920                 925


Leu Lys Ala Lys Tyr Ala Ala Ala Thr Gly Gly Pro Pro Pro Thr Pro 
    930                 935                 940


Leu Pro Asn Met Glu Arg Met Ser Leu Lys Thr Arg Leu Ala Leu Leu 
945                 950                 955                 960


Gly Asp Ala Leu Glu Pro Gly Val Ala Leu Pro Pro Val His Ala Pro 
                965                 970                 975


Arg Arg Cys Ser Asp Gly Gly Ala His Gly Tyr Gly Arg Arg His Leu 
            980                 985                 990


Gln Pro His Asp Ala Pro Gly His Gly Val Arg Arg Ala Ser Asp Pro 
        995                 1000                1005


Val Arg Thr Gly Ser Glu Gly Leu Ala Leu Pro Arg Val Pro Arg Phe 
    1010                1015                1020


Ser Ser Leu Ser Ser Cys Asn Pro Pro Ala Met Ala Thr Ser Ala Glu 
1025                1030                1035                1040


Lys Arg Ser Leu Val Leu Gln Asn Tyr Thr Arg Pro Glu Gly Gly Gln 
                1045                1050                1055


Ser Arg Asn Phe His Ser Ser Pro Cys Pro Pro Ser Ile Thr Glu Asn 
            1060                1065                1070


Val Thr Leu Glu Ser Leu Thr Met Asp Ala Asp Ala Asn Leu Asn Asp 
        1075                1080                1085


Glu Asp Phe Leu Pro Asp Asp Val Val Gln Tyr Leu Asn Ser Gln Asn 
    1090                1095                1100


Gln Ala Gly Tyr Glu Gln His Phe Pro Ser Ala Leu Pro Asp Asp Ser 
1105                1110                1115                1120


Lys Val Pro His Gly Pro Gly Asp Phe Asp Ala Pro Gly Leu Pro Asp 
                1125                1130                1135


Ser His Ala Gly Gln Gln Phe His Ala Leu Glu Gln Pro Cys Pro Glu 
            1140                1145                1150


Gly Ser Lys Thr Asp Leu Pro Ile Gln Trp Asn Glu Val Ser Ser Gly 
        1155                1160                1165


Ser Ala Asp Leu Ser Ser Ser Lys Leu Lys Cys Gly Pro Arg Pro Ala 
    1170                1175                1180


Val Pro Gln Thr Arg Ala Phe Gly Phe Cys Asn Gly Met Val Val His 
1185                1190                1195                1200


Pro Gln Asn Pro Leu Arg Ser Gly Pro Ala Gly Gly Tyr Gln Thr Leu 
                1205                1210                1215


Gly Glu Asn Ser Asn Pro Tyr Gly Gly Pro Glu His Leu Met Leu His 
            1220                1225                1230


Asn Ser Pro Gly Ser Gly Thr Ser Gly Asn Ala Phe His Glu Gln Pro 
        1235                1240                1245


Cys Lys Ala Pro Gln Tyr Gly Asn Cys Leu Asn Arg Gln Pro Val Ala 
    1250                1255                1260


Pro Gly Ala Leu Asp Gly Ala Cys Gly Ala Gly Ile Gln Ala Ser Lys 
1265                1270                1275                1280


Leu Lys Ser Thr Pro Met Gln Gly Ser Gly Gly Gln Leu Asn Phe Gly 
                1285                1290                1295


Leu Pro Val Ala Pro Asn Glu Ser Ala Gly Ser Met Val Asn Gly Met 
            1300                1305                1310


Gln Asn Gln Asp Pro Val Gly Gln Gly Tyr Leu Ala His Gln Leu Leu 
        1315                1320                1325


Gly Asp Ser Met Gln His Pro Gly Ala Gly Arg Pro Gly Gln Gln Met 
    1330                1335                1340


Leu Gly Gln Ile Ser Ala Thr Ser His Ile Asn Ile Tyr Gln Gly Pro 
1345                1350                1355                1360


Glu Ser Cys Leu Pro Gly Ala His Gly Met Gly Ser Gln Pro Ser Ser 
                1365                1370                1375


Leu Ala Val Val Arg Gly Tyr Gln Pro Cys Ala Ser Phe Gly Gly Ser 
            1380                1385                1390


Arg Arg Gln Ala Met Pro Arg Asp Ser Leu Ala Leu Gln Ser Gly Gln 
        1395                1400                1405


Leu Ser Asp Thr Ser Gln Thr Cys Arg Val Asn Gly Ile Lys Met Glu 
    1410                1415                1420


Met Lys Gly Gln Pro His Pro Leu Cys Ser Asn Leu Gln Asn Tyr Ser 
1425                1430                1435                1440


Gly Gln Phe Tyr Asp Gln Thr Val Gly Phe Ser Gln Gln Asp Thr Lys 
                1445                1450                1455


Ala Gly Ser Phe Ser Ile Ser Asp Ala Ser Cys Leu Leu Gln Gly Thr 
            1460                1465                1470


Ser Ala Lys Asn Ser Glu Leu Leu Ser Pro Gly Ala Asn Gln Val Thr 
        1475                1480                1485


Ser Thr Val Asp Ser Leu Asp Ser His Asp Leu Glu Gly Val Gln Ile 
    1490                1495                1500


Asp Phe Asp Ala Ile Ile Asp Asp Gly Asp His Ser Ser Leu Met Ser 
1505                1510                1515                1520


Gly Ala Leu Ser Pro Ser Ile Ile Gln Asn Leu Ser His Ser Ser Ser 
                1525                1530                1535


Arg Leu Thr Thr Pro Arg Ala Ser Leu Pro Phe Pro Ala Leu Ser Met 
            1540                1545                1550


Ser Thr Thr Asn Met Ala Ile Gly Asp Met Ser Ser Leu Leu Thr Ser 
        1555                1560                1565


Leu Ala Glu Glu Ser Lys Phe Leu Ala Val Met Gln 
    1570                1575                1580


<210>  3658
<211>  451
<212>  DNA
<213>  Homo sapiens

<400>  3658
gcggccgcgc ggagcgggga gccgccagcc tgcgccccgt ccgcgggtct atgggaagtt     60

cggggacttg acagccgctg ccgccgcagg gcatttttgg tcgaagagag ctgaagtaat    120

gagaagacat catggaggcc cagtcccaca gctccacgac cactgaaaag aaaaaagttg    180

agaattccat agtgaagtgc tccactcgaa cagatgtgag cgagaaagcc gttgcctcca    240

gcaccacttc taatggcaac catttggagg cccaggccag aggctggacc aggaggattg    300

gatgcatccg cgctgtccat ccctgctgct gcacaaacga ctcagccaca gatcctcttg    360

gatgggctac cttgaaaggg ggaagctcca aagaatgcgt acaaacccat acatttacct    420

aggtgcggga tgattgcaag accactttat t                                   451


<210>  3659
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  3659

Met Glu Ala Gln Ser His Ser Ser Thr Thr Thr Glu Lys Lys Lys Val 
1               5                   10                  15


Glu Asn Ser Ile Val Lys Cys Ser Thr Arg Thr Asp Val Ser Glu Lys 
            20                  25                  30


Ala Val Ala Ser Ser Thr Thr Ser Asn Gly Asn His Leu Glu Ala Gln 
        35                  40                  45


Ala Arg Gly Trp Thr Arg Arg Ile Gly Cys Ile Arg Ala Val His Pro 
    50                  55                  60


Cys Cys Cys Thr Asn Asp Ser Ala Thr Asp Pro Leu Gly Trp Ala Thr 
65                  70                  75                  80


Leu Lys Gly Gly Ser Ser Lys Glu Cys Val Gln Thr His Thr Phe Thr 
                85                  90                  95


<210>  3660
<211>  1767
<212>  DNA
<213>  Homo sapiens

<400>  3660
agctgggacc cactccgggc ttggggaccc ggcgggcggg agaagcgggg gctcccggcg     60

cggcctggaa ggagcgagaa agcaaaaggc atttttggtc gaagagagct gaagtaatga    120

gaagacatca tggaggccca gtcccacagc tccacgacca ctgaaaagaa aaaagttgag    180

aattccatag tgaagtgctc cactcgaaca gatgtgagcg agaaagccgt tgcctccagc    240

accacttcta atggtgagca gcacagggat taccagcagc ccagcctgga gtcatttctg    300

tgttctctgc attccttgtg aattgagcgt ttgcacctgg accagtgttt gttctaggag    360

acgctaaaga aagcaaatgg agcaggggcg gggggacggc ggggggacat ggaatgtagt    420

aatctctatt ttggcactca acctacacgt tgacttccaa actttctaat ttgagatgta    480

aatgtgatag gttatttatt atcagaagtt cctgttttgg cattttggaa atcatcttga    540

ctagtctggc aagagttcaa aatgctttgt gttgcatatg gatcatctac actactcgga    600

ataattagta caaaagacac aaaagttgtc ttgtcaaaat tagtgacagg acagcagtct    660

cctccaaccc caactttaag tagtctactt taaaggattt taagaattgt taatgactga    720

acctcaaggt aatgttagta tctgagatgc aggttttgtt gttagcttat aaaaatttaa    780

tttacttatt tgtgttcaga gataacacag agccactgtt tctgtattct gtgtttttaa    840

agtttaagca aagtgttgag aggcatttca gttcaagcat ggagtgttga aaataaattc    900

cagagcatcc ctggtacaaa cagactgaat atgttaatgg taaccttcac ttcctgtccc    960

tgctgtttct ccattgtggg ccactaatgc ctttcctttt tgtagatttc atagccattc   1020

ttggcctccc tgaatttctc tgcttttcca tgggccttta ggaagaatga gctggcccgt   1080

tttcctcgtt cctggacact gcctatctgg gcacactgat ttgtatgagt caacctgcta   1140

ttcttatatt ttctatattc caagacaggt tttacttgat tgatttacaa gtttttacat   1200

ccacctagag agtcagaatc tcctttggaa ggtaactgca gtccagaaca ttagactcta   1260

agggcatata cttccaagca gcctggccac ttctctctgg gtccctccat gtctgctgag   1320

agcctgtgct tctcacctgc acttcttcac ccggtttcat gagtgtgctt tgctgactgt   1380

actgggtagg gaaggagctg gctcttaaac ctgctggcaa atgacttcag ttttaaattg   1440

atcctgaggg agatatattt acgtctgagt taaaataatg aatttacata tatgtgaaaa   1500

tatttcctcc tttattgatg gtatttaaag tcaagactgg agcttatttt aattgagcca   1560

gaatatttgc atttttcatc caatgtggtt atagaaggca tttctcctta gaaatatgtt   1620

accttggttt cttttttctg gaattggtaa aatttaggca aatttattat ttcagaaata   1680

gaatcagtat atgcagtgtt ggttatttgg taatttttat ggtaattctg tcggaataaa   1740

tgcttcctat gtacttggct tcaggaa                                       1767


<210>  3661
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  3661

Met Glu Ala Gln Ser His Ser Ser Thr Thr Thr Glu Lys Lys Lys Val 
1               5                   10                  15


Glu Asn Ser Ile Val Lys Cys Ser Thr Arg Thr Asp Val Ser Glu Lys 
            20                  25                  30


Ala Val Ala Ser Ser Thr Thr Ser Asn Gly Glu Gln His Arg Asp Tyr 
        35                  40                  45


Gln Gln Pro Ser Leu Glu Ser Phe Leu Cys Ser Leu His Ser Leu 
    50                  55                  60


<210>  3662
<211>  548
<212>  DNA
<213>  Homo sapiens

<400>  3662
ctttaggaaa ctttgtatct catactctcc gcccctcctc cagcacgcaa agcctgagaa     60

cttagatctt agttaaaaga gagcttgtat ttatacataa aactttgcaa atcaccattc    120

attctttcca cagactttgg ggaatttcaa tgttttgctt ttcatcttcc tgagagtcca    180

gaagcctccc cgtcagaagt gtgttaacag cagttcagcc catttcaggg tgaaggacag    240

tttgtcatct aactgtttta accctcttag ggagaaagta catagactga aaagaatttg    300

actggtgatt ttcaaaaata ttttttactt tcatgatctc aaaagattaa agattccaga    360

gaaggtgggg agagaacttc aaaagtttgc ctcacaactc ttttggatca aagggatttt    420

attttcctgg cactgaagaa ctaaaagata cataaaacgg cacaatattt tatagggttc    480

cttatggatg ggctattctt taaatgctga ggaaggaaac aaataatgca ccagactatt    540

taattaaa                                                             548


<210>  3663
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  3663

Asn Phe Ala Asn His His Ser Phe Phe Pro Gln Thr Leu Gly Asn Phe 
1               5                   10                  15


Asn Val Leu Leu Phe Ile Phe Leu Arg Val Gln Lys Pro Pro Arg Gln 
            20                  25                  30


Lys Cys Val Asn Ser Ser Ser Ala His Phe Arg Val Lys Asp Ser Leu 
        35                  40                  45


Ser Ser Asn Cys Phe Asn Pro Leu Arg Glu Lys Val His Arg Leu Lys 
    50                  55                  60


Arg Ile 
65


<210>  3664
<211>  602
<212>  DNA
<213>  Homo sapiens

<400>  3664
ggccgggcct catctgtggg gtgaggcctc cacctccagc acctggtaga gaagtccaag     60

ggtactggct cccacagagc aggggctggg agaagtcctg agactgagag gcctgcacaa    120

atcactttag taacacccaa tgcaaccaag atatgctctt gcttttactt ttgcttggag    180

aaaaaaatcc ttacaggcta caaaaggtca gaatattcta gaaagcaaat ctgaaggaac    240

atgaccatct gttcagttta aatcttcact gagctgagca aacagaagaa taatcctgca    300

gatggagaaa tgctgcacat cacaaggtcc gtatcatagc agtgtgaggt tagcttcccc    360

aggtccagtt cccatacacc atccattact ctgctctgtt tatcagaaaa atgtgccacc    420

aagcaatcaa tacattttcc aagtgaacaa aacaggacag aaacctccca gctcttcctt    480

agcaataagc catgctgagt gttcctcccc acacagggct gacctcacca cactgctgtg    540

accccagcct gagcagaggg agacagagca gaaaggaatt gaccacagct gctgcaagga    600

ca                                                                   602


<210>  3665
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  3665

Met Glu Lys Cys Cys Thr Ser Gln Gly Pro Tyr His Ser Ser Val Arg 
1               5                   10                  15


Leu Ala Ser Pro Gly Pro Val Pro Ile His His Pro Leu Leu Cys Ser 
            20                  25                  30


Val Tyr Gln Lys Asn Val Pro Pro Ser Asn Gln Tyr Ile Phe Gln Val 
        35                  40                  45


Asn Lys Thr Gly Gln Lys Pro Pro Ser Ser Ser Leu Ala Ile Ser His 
    50                  55                  60


Ala Glu Cys Ser Ser Pro His Arg Ala Asp Leu Thr Thr Leu Leu 
65                  70                  75


<210>  3666
<211>  5486
<212>  DNA
<213>  Homo sapiens

<400>  3666
gcttgtgacc cttccatcac taccccaatt ccccctctct gcccactcaa ccccacctag     60

cccatcgtcc tcactcccca ccacactcac cccaaccagt accccacacc ccacaaacaa    120

gagggtgtga cttgcaggga acaaaagcag gatgtcccct ttatctgaga cacctccaga    180

tgagggctct ctgggaccca taagtgtctc tgtgaacaat aagctcccca cgaggtgggc    240

ttcccctggg attacaggca gtgtctctag tggtatcaga gctcaacact gaagtggtgc    300

tcctggggac acgggcattg actctgagca cctctgtgag ataggcgcgc ccagggactg    360

tctccacaag ctttgacacc ccactgaggt gggagctccc tggaaacaaa cagtgtctct    420

gcagtctcag agcttgacac tgaagtggag ctccctggca cgccagcggt gtgtttgcaa    480

actgtggcct gcccactgtg tcctctggtt cacagacagt gtttccacag actccgaact    540

cccccactga actgggagca ccctatgact ggagcagtgt ctctagggac ttggagctcc    600

ccactgagtt aggagttccc tgcagcacag acatggtccc caccaactct cagctcccca    660

gtgcagtggg agctccctgg aacacagcag tttctccctg gtacacaggc ggtgtttcca    720

tggattctga gctctttact gaggtgggag ctccctgaga caagcacagt gtctcacaga    780

ctctgtgctc cccatgagac aggagctccc tgggtagcgg gcagggtctc cagggtctat    840

gaaccgcccg ctgaggtggg agcctcctgg gatgcaagga gtgcctttaa ggactctgag    900

cttccatggt gtggtgctcc ctgggacacg gcagtgtctt cacgactctg acttcccact    960

gaagtcacac tctctgggac acagcagtgt ctgtaaggac tctgaactcc actgaggtgg   1020

gagccccctg ggctgtcttt ccagtgagtc tgcactgagg tgggagctca ctgggaaacc   1080

agtagtgtct ctgtggactc tgacctttat ttgaggtaaa agctccctga gacactggca   1140

gtgtctccac agactctgag cctccccctg gtgggagccc ctgggaacac agagggcgtc   1200

tccacagact ctgagctctc actgaaatga agctccctgg gactccggca ggatctccac   1260

agactcttac ctccccactg aaatgggaga ttttgggaca tgggcagggt ctccatggac   1320

tcagagttcc cccattgaag ggggagttcg gtggcacatg ggcattgtct ctaatgactc   1380

tgagctcctg gctgagggga ttgctccctg ggacgttgcc agggtctcca cagactctga   1440

gctccccatg aggtgggagc tccacaggat ttgggcaggg tctccatgaa ctataaactc   1500

tccactgagg tgggagctcc ctgggacaca gagagttttt ttcagactct gaactcccat   1560

gaaatggagc tctttggagc atggacagtg tctttaagga ctctgagcta cccaccgagg   1620

tgggagctca gtgggacatg tgaagcagtg tctccacgga ctctgggctg cccactcagg   1680

tgggctgtgt cttggacaca ggcagtgtct ctatcaactt tgggctctgc tctgaggtaa   1740

gagccccctg ggacaggggc actatctcct tggactttga actcccacca aagtggagct   1800

cactgggaca gtggcaacgt ctccacggat tctgagctcc cgctgaagtg gagctccctg   1860

ggaatcagtc agtgtccaag aactctgagc ttccctgagg tgggagccct ctggaacaca   1920

aggagtgtcc acgcagactc tgagtttcca tgaagtaggg ctgtctggga cactggcggt   1980

gtctctatgg tctctgagct cctcacggag ctgggagctc cctcggacat gggcgatgtc   2040

tccacaaact ctccattccc ctatgaggtg gaagctctct gcgacatgac cattgtctct   2100

gtggaatctg agcttcccac tagtgggagc cccttgggac acagggcagg gtctccacag   2160

actctaagct cccactgaag tggagctctc tggaataaca gcaggatctc cacagactct   2220

taccacctcc agtgaagtgg gaacttttgg gacacaggca gtgtctccat ggactctgag   2280

ctccctgctg aggtgggagt tcatgtggca ccagttgtgt ctccacagac gctgagctcc   2340

ctaggacatg ggctctccct gggtggagag caatgtctcc acggaacctg tgctccctac   2400

tgaggtggga gcttcctggg acaggggcag ggtctccagt aactctgagc tcccactgaa   2460

gtggagctcc ctaggattct gcagtttgtc cacaaactct tacctcctca ctcagtggga   2520

ggttttggga cccgggtagt gtctccacat actctgagct acccactgag gtgggatccc   2580

cctgggtcga gggcaatgtc tccacaggga ctgagctccc taccaagatg aggtctggca   2640

caagaacagt gacttcatgg tggagtcata gctcccactg aagtggagct ccctgaccca   2700

ctgaacagct gaatggggag cttgctggca cacagaaact gttcacactg tctgaccttc   2760

ccccacgttt gttcgttcaa tactggaagg aagcgcaagt ctgtttgttc tcctgcctgt   2820

gtgtgtgtac agggggacat cctgggagct tatttgtcta aaggatgcct gtgtcctcta   2880

gttgctgaga ggcagtgagg acaagcagct gcatgaactg cacttggaga gaaaccctgc   2940

tgtatacaat ttcacacacc agggagcagg actcaacatg actgtgcaca gtgccttgga   3000

cagtgatgag cagagccacc aggcagtgac cgaggccatg agggtcatcg gcttcagtcc   3060

tgaagaggtg gagtctgtgc atcgcatcct ggctgccata ttgcacctgg gaaacatcga   3120

gtttgtggag acggaggagg gtgggctgca gaaggagggc ctggcagtgg ccgaggaggc   3180

actggtggac catgtggctg agctgacggc cacaccccgg gacctcgtgc tccgctccct   3240

gctggctcgc acagttgcct cgggaggcag ggaactcata gagaagggcc acactgcagc   3300

tgaggccagc tatgcccggg atgcctgtgc caaggcagtg taccagcggc tgtttgagtg   3360

ggtggtgaac aggatcaaca gtgtcatgga accccggggc cgggatcctc ggcgtgatgg   3420

caaggacaca gtcattggcg tgctggacat ctatggcttc gaggtgtttc ccgtcaacag   3480

tttcgagcag ttctgcatca actactgcaa cgagaagctg cagcagctat tcatccagct   3540

catcctgaag caggaacagg aagagtacga gcgcgagggc atcacctggc agagcgttga   3600

gtatttcaac aacgccacca ttgtggatct ggtggagcgg ccccaccgtg gcatcctggc   3660

cgtgctggac gaggcctgca gctctgctgg caccatcact gaccgaatct tcctgcagac   3720

cctggacatg caccaccgcc atcacctaca ctacaccagc cgccagctct gccccacaga   3780

caagaccatg gagtttggcc gagacttccg gatcaagcac tatgcagggg acgtcacgta   3840

ctccgtggaa ggcttcatcg acaagaacag agatttcctc ttccaggact tcaagcggct   3900

gctgtacaac agcacggacc ccactctacg ggccatgtgg ccggacgggc agcaggacat   3960

cacagaggtg accaagcgcc ccctgacggc tggcacactc ttcaagaact ccatggtggc   4020

cctggtggag aaccttgcct ccaaggagcc cttctacgtc cgctgcatca agcccaatga   4080

ggacaaggta gctgggaagc tggatgagaa ccactgtcgc caccaggtcg catacctggg   4140

gctgctggag aatgtgaggg tccgcagggc tggcttcgct tcccgccagc cctactctcg   4200

attcctgctc aggtacaaga tgacctgtga atacacatgg cccaaccacc tgctgggctc   4260

cgacaaggca gccgtgagcg ctctcctgga gcagcacggg ctgcaggggg acgtggcctt   4320

tggccacagc aagctgttca tccgctcacc ccggacactg gtcacactgg agcagagccg   4380

agcccgcctc atccccatca ttgtgctgct attgcagaag gcatggcggg gcaccttggc   4440

gaggtggcgc tgccggaggc tgagggctat ctacaccatc atgcgctggt tccggagaca   4500

caaggtgcgg gctcacctgg ctgagctgca gcggcgattc caggctgcaa ggcagccgcc   4560

actctacggg cgtgaccttg tgtggccgct gccccctgct gtgctgcagc ccttccagga   4620

cacctgccac gcactcttct gcaggtggcg ggcccggcag ctggtgaaga acatcccccc   4680

ttcagacatg ccccagatca aggccaaggt ggccgccatg ggggccctgc aagggcttcg   4740

tcaggactgg ggctgccgac gggcctgggc ccgagactac ctgtcctctg ccactgacaa   4800

tcccacagca tcaagcctgt ttgctcagcg actaaagaca cttcaggaca aagatggctt   4860

cggggctgtg ctcttttcaa gccatgtccg caaggtgaac cgcttccaca agatccggaa   4920

ccgggccctc ctgctcacag accagcacct ctacaagctg gaccctgacc ggcagtaccg   4980

ggtgatgcgg gccgtgcccc ttgaggcggt gacggggctg agcgtgacca gcggaggaga   5040

ccagctggtg gtgctgcacg cccgcggcca ggacgacctc gtggtgtgcc tgcaccgctc   5100

ccggccgcca ttggacaacc gcgttgggga gctggtgggc gtgctggccg cacactgcca   5160

gggggagggc cgcaccctgg aggttcgcgt ctccgactgc atcccactaa gccatcgcgg   5220

ggtccggcgc ctcatctccg tggagcccag gccggagcag ccagagcccg atttccgctg   5280

cgctcgcggc tccttcaccc tgctctggcc cagccgctga gcgcccgcac ccgccgcacc   5340

ccgaggccgc caattgtccg ccccgccagc gctgcaaata aaccttctga gtcagccctc   5400

ctgctcgccg ctcccgcctc acccgcaggg gctccggccg cctcctcggt caggtccacc   5460

tgcgcccggc tcacccgctg gggacc                                        5486


<210>  3667
<211>  780
<212>  PRT
<213>  Homo sapiens

<400>  3667

Met Thr Val His Ser Ala Leu Asp Ser Asp Glu Gln Ser His Gln Ala 
1               5                   10                  15


Val Thr Glu Ala Met Arg Val Ile Gly Phe Ser Pro Glu Glu Val Glu 
            20                  25                  30


Ser Val His Arg Ile Leu Ala Ala Ile Leu His Leu Gly Asn Ile Glu 
        35                  40                  45


Phe Val Glu Thr Glu Glu Gly Gly Leu Gln Lys Glu Gly Leu Ala Val 
    50                  55                  60


Ala Glu Glu Ala Leu Val Asp His Val Ala Glu Leu Thr Ala Thr Pro 
65                  70                  75                  80


Arg Asp Leu Val Leu Arg Ser Leu Leu Ala Arg Thr Val Ala Ser Gly 
                85                  90                  95


Gly Arg Glu Leu Ile Glu Lys Gly His Thr Ala Ala Glu Ala Ser Tyr 
            100                 105                 110


Ala Arg Asp Ala Cys Ala Lys Ala Val Tyr Gln Arg Leu Phe Glu Trp 
        115                 120                 125


Val Val Asn Arg Ile Asn Ser Val Met Glu Pro Arg Gly Arg Asp Pro 
    130                 135                 140


Arg Arg Asp Gly Lys Asp Thr Val Ile Gly Val Leu Asp Ile Tyr Gly 
145                 150                 155                 160


Phe Glu Val Phe Pro Val Asn Ser Phe Glu Gln Phe Cys Ile Asn Tyr 
                165                 170                 175


Cys Asn Glu Lys Leu Gln Gln Leu Phe Ile Gln Leu Ile Leu Lys Gln 
            180                 185                 190


Glu Gln Glu Glu Tyr Glu Arg Glu Gly Ile Thr Trp Gln Ser Val Glu 
        195                 200                 205


Tyr Phe Asn Asn Ala Thr Ile Val Asp Leu Val Glu Arg Pro His Arg 
    210                 215                 220


Gly Ile Leu Ala Val Leu Asp Glu Ala Cys Ser Ser Ala Gly Thr Ile 
225                 230                 235                 240


Thr Asp Arg Ile Phe Leu Gln Thr Leu Asp Met His His Arg His His 
                245                 250                 255


Leu His Tyr Thr Ser Arg Gln Leu Cys Pro Thr Asp Lys Thr Met Glu 
            260                 265                 270


Phe Gly Arg Asp Phe Arg Ile Lys His Tyr Ala Gly Asp Val Thr Tyr 
        275                 280                 285


Ser Val Glu Gly Phe Ile Asp Lys Asn Arg Asp Phe Leu Phe Gln Asp 
    290                 295                 300


Phe Lys Arg Leu Leu Tyr Asn Ser Thr Asp Pro Thr Leu Arg Ala Met 
305                 310                 315                 320


Trp Pro Asp Gly Gln Gln Asp Ile Thr Glu Val Thr Lys Arg Pro Leu 
                325                 330                 335


Thr Ala Gly Thr Leu Phe Lys Asn Ser Met Val Ala Leu Val Glu Asn 
            340                 345                 350


Leu Ala Ser Lys Glu Pro Phe Tyr Val Arg Cys Ile Lys Pro Asn Glu 
        355                 360                 365


Asp Lys Val Ala Gly Lys Leu Asp Glu Asn His Cys Arg His Gln Val 
    370                 375                 380


Ala Tyr Leu Gly Leu Leu Glu Asn Val Arg Val Arg Arg Ala Gly Phe 
385                 390                 395                 400


Ala Ser Arg Gln Pro Tyr Ser Arg Phe Leu Leu Arg Tyr Lys Met Thr 
                405                 410                 415


Cys Glu Tyr Thr Trp Pro Asn His Leu Leu Gly Ser Asp Lys Ala Ala 
            420                 425                 430


Val Ser Ala Leu Leu Glu Gln His Gly Leu Gln Gly Asp Val Ala Phe 
        435                 440                 445


Gly His Ser Lys Leu Phe Ile Arg Ser Pro Arg Thr Leu Val Thr Leu 
    450                 455                 460


Glu Gln Ser Arg Ala Arg Leu Ile Pro Ile Ile Val Leu Leu Leu Gln 
465                 470                 475                 480


Lys Ala Trp Arg Gly Thr Leu Ala Arg Trp Arg Cys Arg Arg Leu Arg 
                485                 490                 495


Ala Ile Tyr Thr Ile Met Arg Trp Phe Arg Arg His Lys Val Arg Ala 
            500                 505                 510


His Leu Ala Glu Leu Gln Arg Arg Phe Gln Ala Ala Arg Gln Pro Pro 
        515                 520                 525


Leu Tyr Gly Arg Asp Leu Val Trp Pro Leu Pro Pro Ala Val Leu Gln 
    530                 535                 540


Pro Phe Gln Asp Thr Cys His Ala Leu Phe Cys Arg Trp Arg Ala Arg 
545                 550                 555                 560


Gln Leu Val Lys Asn Ile Pro Pro Ser Asp Met Pro Gln Ile Lys Ala 
                565                 570                 575


Lys Val Ala Ala Met Gly Ala Leu Gln Gly Leu Arg Gln Asp Trp Gly 
            580                 585                 590


Cys Arg Arg Ala Trp Ala Arg Asp Tyr Leu Ser Ser Ala Thr Asp Asn 
        595                 600                 605


Pro Thr Ala Ser Ser Leu Phe Ala Gln Arg Leu Lys Thr Leu Gln Asp 
    610                 615                 620


Lys Asp Gly Phe Gly Ala Val Leu Phe Ser Ser His Val Arg Lys Val 
625                 630                 635                 640


Asn Arg Phe His Lys Ile Arg Asn Arg Ala Leu Leu Leu Thr Asp Gln 
                645                 650                 655


His Leu Tyr Lys Leu Asp Pro Asp Arg Gln Tyr Arg Val Met Arg Ala 
            660                 665                 670


Val Pro Leu Glu Ala Val Thr Gly Leu Ser Val Thr Ser Gly Gly Asp 
        675                 680                 685


Gln Leu Val Val Leu His Ala Arg Gly Gln Asp Asp Leu Val Val Cys 
    690                 695                 700


Leu His Arg Ser Arg Pro Pro Leu Asp Asn Arg Val Gly Glu Leu Val 
705                 710                 715                 720


Gly Val Leu Ala Ala His Cys Gln Gly Glu Gly Arg Thr Leu Glu Val 
                725                 730                 735


Arg Val Ser Asp Cys Ile Pro Leu Ser His Arg Gly Val Arg Arg Leu 
            740                 745                 750


Ile Ser Val Glu Pro Arg Pro Glu Gln Pro Glu Pro Asp Phe Arg Cys 
        755                 760                 765


Ala Arg Gly Ser Phe Thr Leu Leu Trp Pro Ser Arg 
    770                 775                 780


<210>  3668
<211>  5398
<212>  DNA
<213>  Homo sapiens

<400>  3668
gcttgtgacc cttccatcac taccccaatt ccccctctct gcccactcaa ccccacctag     60

cccatcgtcc tcactcccca ccacactcac cccaaccagt accccacacc ccacaaacaa    120

gagggtgtga cttgcaggga acaaaagcag gatgtcccct ttatctgaga cacctccaga    180

tgagggctct ctgggaccca taagtgtctc tgtgaacaat aagctcccca cgaggtgggc    240

ttcccctggg attacaggca gtgtctctag tggtatcaga gctcaacact gaagtggtgc    300

tcctggggac acgggcattg actctgagca cctctgtgag ataggcgcgc ccagggactg    360

tctccacaag ctttgacacc ccactgaggt gggagctccc tggaaacaaa cagtgtctct    420

gcagtctcag agcttgacac tgaagtggag ctccctggca cgccagcggt gtgtttgcaa    480

actgtggcct gcccactgtg tcctctggtt cacagacagt gtttccacag actccgaact    540

cccccactga actgggagca ccctatgact ggagcagtgt ctctagggac ttggagctcc    600

ccactgagtt aggagttccc tgcagcacag acatggtccc caccaactct cagctcccca    660

gtgcagtggg agctccctgg aacacagcag tttctccctg gtacacaggc ggtgtttcca    720

tggattctga gctctttact gaggtgggag ctccctgaga caagcacagt gtctcacaga    780

ctctgtgctc cccatgagac aggagctccc tgggtagcgg gcagggtctc cagggtctat    840

gaaccgcccg ctgaggtggg agcctcctgg gatgcaagga gtgcctttaa ggactctgag    900

cttccatggt gtggtgctcc ctgggacacg gcagtgtctt cacgactctg acttcccact    960

gaagtcacac tctctgggac acagcagtgt ctgtaaggac tctgaactcc actgaggtgg   1020

gagccccctg ggctgtcttt ccagtgagtc tgcactgagg tgggagctca ctgggaaacc   1080

agtagtgtct ctgtggactc tgacctttat ttgaggtaaa agctccctga gacactggca   1140

gtgtctccac agactctgag cctccccctg gtgggagccc ctgggaacac agagggcgtc   1200

tccacagact ctgagctctc actgaaatga agctccctgg gactccggca ggatctccac   1260

agactcttac ctccccactg aaatgggaga ttttgggaca tgggcagggt ctccatggac   1320

tcagagttcc cccattgaag ggggagttcg gtggcacatg ggcattgtct ctaatgactc   1380

tgagctcctg gctgagggga ttgctccctg ggacgttgcc agggtctcca cagactctga   1440

gctccccatg aggtgggagc tccacaggat ttgggcaggg tctccatgaa ctataaactc   1500

tccactgagg tgggagctcc ctgggacaca gagagttttt ttcagactct gaactcccat   1560

gaaatggagc tctttggagc atggacagtg tctttaagga ctctgagcta cccaccgagg   1620

tgggagctca gtgggacatg tgaagcagtg tctccacgga ctctgggctg cccactcagg   1680

tgggctgtgt cttggacaca ggcagtgtct ctatcaactt tgggctctgc tctgaggtaa   1740

gagccccctg ggacaggggc actatctcct tggactttga actcccacca aagtggagct   1800

cactgggaca gtggcaacgt ctccacggat tctgagctcc cgctgaagtg gagctccctg   1860

ggaatcagtc agtgtccaag aactctgagc ttccctgagg tgggagccct ctggaacaca   1920

aggagtgtcc acgcagactc tgagtttcca tgaagtaggg ctgtctggga cactggcggt   1980

gtctctatgg tctctgagct cctcacggag ctgggagctc cctcggacat gggcgatgtc   2040

tccacaaact ctccattccc ctatgaggtg gaagctctct gcgacatgac cattgtctct   2100

gtggaatctg agcttcccac tagtgggagc cccttgggac acagggcagg gtctccacag   2160

actctaagct cccactgaag tggagctctc tggaataaca gcaggatctc cacagactct   2220

taccacctcc agtgaagtgg gaacttttgg gacacaggca gtgtctccat ggactctgag   2280

ctccctgctg aggtgggagt tcatgtggca ccagttgtgt ctccacagac gctgagctcc   2340

ctaggacatg ggctctccct gggtggagag caatgtctcc acggaacctg tgctccctac   2400

tgaggtggga gcttcctggg acaggggcag ggtctccagt aactctgagc tcccactgaa   2460

gtggagctcc ctaggattct gcagtttgtc cacaaactct tacctcctca ctcagtggga   2520

ggttttggga cccgggtagt gtctccacat actctgagct acccactgag gtgggatccc   2580

cctgggtcga gggcaatgtc tccacaggga ctgagctccc taccaagatg aggtctggca   2640

caagaacagt gacttcatgg tggagtcata gctcccactg aagtggagct ccctgaccca   2700

ctgaacagct gaatggggag cttgctggca cacagaaact gttcacactg tctgaccttc   2760

ccccacgttt gttcgttcaa tactggaagg aagcgcaagt ctgtttgttc tcctgcctgt   2820

gtgtgtgtac agggggacat cctgggagct tatttgtcta aaggatgcct gtgtcctcta   2880

gttgctgaga ggcagtgagg acaagcagct gcatgaactg cacttggaga gaaaccctgc   2940

tgtatacaat ttcacacacc agggagcagg actcaacatg actgtgcaca gtgccttgga   3000

cagtgatgag cagagccacc aggcagtgac cgaggccatg agggtcatcg gcttcagtcc   3060

tgaagaggtg gagtctgtgc atcgcatcct ggctgccata ttgcacctgg gaaacatcga   3120

gtttgtggag acggaggagg gtgggctgca gaaggagggc ctggcagtgg ccgaggaggc   3180

actggtggac catgtggctg agctgacggc cacaccccgg gacctcgtgc tccgctccct   3240

gctggctcgc acagttgcct cgggaggcag ggaactcata gagaagggcc acactgcagc   3300

tgaggccagc tatgcccggg atgcctgtgc caaggcagtg taccagcggc tgtttgagtg   3360

ggtggtgaac aggatcaaca gtgtcatgga accccggggc cgggatcctc ggcgtgatgg   3420

caaggacaca gtcattggcg tgctggacat ctatggcttc gaggtgtttc ccgtcaacag   3480

tttcgagcag ttctgcatca actactgcaa cgagaagctg cagcagctat tcatccagct   3540

catcctgaag caggaacagg aagagtacga gcgcgagggc atcacctggc agagcgttga   3600

gtatttcaac aacgccacca ttgtggatct ggtggagcgg ccccaccgtg gcatcctggc   3660

cgtgctggac gaggcctgca gctctgctgg caccatcact gaccgaatct tcctgcagac   3720

cctggacatg caccaccgcc atcacctaca ctacaccagc cgccagctct gccccacaga   3780

caagaccatg gagtttggcc gagacttccg gatcaagcac tatgcagggg acgtcacgta   3840

ctccgtggaa ggcttcatcg acaagaacag agatttcctc ttccaggact tcaagcggct   3900

gctgtacaac agcacggacc ccactctacg ggccatgtgg ccggacgggc agcaggacat   3960

cacagaggtg accaagcgcc ccctgacggc tggcacactc ttcaagaact ccatggtggc   4020

cctggtggag aaccttgcct ccaaggagcc cttctacgtc cgctgcatca agcccaatga   4080

ggacaaggta gctgggaagc tggatgagaa ccactgtcgc caccaggtcg catacctggg   4140

gctgctggag aatgtgaggg tccgcagggc tggcttcgct tcccgccagc cctactctcg   4200

attcctgctc aggtacaaga tgacctgtga atacacatgg cccaaccacc tgctgggctc   4260

cgacaaggca gccgtgagcg ctctcctgga gcagcacggg ctgcaggggg acgtggcctt   4320

tggccacagc aagctgttca tccgctcacc ccggacactg gtcacactgg agcagagccg   4380

agcccgcctc atccccatca ttgtgctgct attgcagaag gcatggcggg gcaccttggc   4440

gaggtggcgc tgccggaggc tgagggctat ctacaccatc atgcgctggt tccggagaca   4500

caaggtgcgg gctcacctgg ctgagctgca gcggcgattc caggctgcaa ggcagccgcc   4560

actctacggg cgtgaccttg tgtggccgct gccccctgct gtgctgcagc ccttccagga   4620

cacctgccac gcactcttct gcaggtggcg ggcccggcag ctggtgaaga acatcccccc   4680

ttcagacatg ccccagatca aggccaaggt ggccgccatg ggggccctgc aagggcttcg   4740

tcaggactgg ggctgccgac gggcctgggc ccgagactac ctgtcctctg ccactgacaa   4800

tcccacagca tcaagcctgt ttgctcagcg actaaagaca cttcaggaca aagatggctt   4860

cggggctgtg ctcttttcaa gccatgtccg caaggtgaac cgcttccaca agatccggaa   4920

ccgggccctc ctgctcacag accagcacct ctacaagctg gaccctgacc ggcagtaccg   4980

ggtgatgcgg gccgtgcccc ttgaggcggt gacggggctg agcgtgacca gcggaggaga   5040

ccagctggtg gtgctgcacg cccgcggcca ggacgacctc gtggtgtgcc tgcaccgctc   5100

ccggccgcca ttggacaacc gcgttgggga gctggtgggc gtgctggccg cacactgcca   5160

gggggagggc cgcaccctgg aggttcgcgt ctccgactgc atcccactaa gccatcgcgg   5220

ggtccggcgc ctcatctccg tggagcccag gccggagcag ccagagcccg atttccgctg   5280

cgctcgcggc tccttcaccc tgctctggcc cagccgctga gcgcccgcac ccgccgcacc   5340

ccgaggccgc caattgtccg ccccgccagc gctgcaaata aaccttctga gtcagccc     5398


<210>  3669
<211>  780
<212>  PRT
<213>  Homo sapiens

<400>  3669

Met Thr Val His Ser Ala Leu Asp Ser Asp Glu Gln Ser His Gln Ala 
1               5                   10                  15


Val Thr Glu Ala Met Arg Val Ile Gly Phe Ser Pro Glu Glu Val Glu 
            20                  25                  30


Ser Val His Arg Ile Leu Ala Ala Ile Leu His Leu Gly Asn Ile Glu 
        35                  40                  45


Phe Val Glu Thr Glu Glu Gly Gly Leu Gln Lys Glu Gly Leu Ala Val 
    50                  55                  60


Ala Glu Glu Ala Leu Val Asp His Val Ala Glu Leu Thr Ala Thr Pro 
65                  70                  75                  80


Arg Asp Leu Val Leu Arg Ser Leu Leu Ala Arg Thr Val Ala Ser Gly 
                85                  90                  95


Gly Arg Glu Leu Ile Glu Lys Gly His Thr Ala Ala Glu Ala Ser Tyr 
            100                 105                 110


Ala Arg Asp Ala Cys Ala Lys Ala Val Tyr Gln Arg Leu Phe Glu Trp 
        115                 120                 125


Val Val Asn Arg Ile Asn Ser Val Met Glu Pro Arg Gly Arg Asp Pro 
    130                 135                 140


Arg Arg Asp Gly Lys Asp Thr Val Ile Gly Val Leu Asp Ile Tyr Gly 
145                 150                 155                 160


Phe Glu Val Phe Pro Val Asn Ser Phe Glu Gln Phe Cys Ile Asn Tyr 
                165                 170                 175


Cys Asn Glu Lys Leu Gln Gln Leu Phe Ile Gln Leu Ile Leu Lys Gln 
            180                 185                 190


Glu Gln Glu Glu Tyr Glu Arg Glu Gly Ile Thr Trp Gln Ser Val Glu 
        195                 200                 205


Tyr Phe Asn Asn Ala Thr Ile Val Asp Leu Val Glu Arg Pro His Arg 
    210                 215                 220


Gly Ile Leu Ala Val Leu Asp Glu Ala Cys Ser Ser Ala Gly Thr Ile 
225                 230                 235                 240


Thr Asp Arg Ile Phe Leu Gln Thr Leu Asp Met His His Arg His His 
                245                 250                 255


Leu His Tyr Thr Ser Arg Gln Leu Cys Pro Thr Asp Lys Thr Met Glu 
            260                 265                 270


Phe Gly Arg Asp Phe Arg Ile Lys His Tyr Ala Gly Asp Val Thr Tyr 
        275                 280                 285


Ser Val Glu Gly Phe Ile Asp Lys Asn Arg Asp Phe Leu Phe Gln Asp 
    290                 295                 300


Phe Lys Arg Leu Leu Tyr Asn Ser Thr Asp Pro Thr Leu Arg Ala Met 
305                 310                 315                 320


Trp Pro Asp Gly Gln Gln Asp Ile Thr Glu Val Thr Lys Arg Pro Leu 
                325                 330                 335


Thr Ala Gly Thr Leu Phe Lys Asn Ser Met Val Ala Leu Val Glu Asn 
            340                 345                 350


Leu Ala Ser Lys Glu Pro Phe Tyr Val Arg Cys Ile Lys Pro Asn Glu 
        355                 360                 365


Asp Lys Val Ala Gly Lys Leu Asp Glu Asn His Cys Arg His Gln Val 
    370                 375                 380


Ala Tyr Leu Gly Leu Leu Glu Asn Val Arg Val Arg Arg Ala Gly Phe 
385                 390                 395                 400


Ala Ser Arg Gln Pro Tyr Ser Arg Phe Leu Leu Arg Tyr Lys Met Thr 
                405                 410                 415


Cys Glu Tyr Thr Trp Pro Asn His Leu Leu Gly Ser Asp Lys Ala Ala 
            420                 425                 430


Val Ser Ala Leu Leu Glu Gln His Gly Leu Gln Gly Asp Val Ala Phe 
        435                 440                 445


Gly His Ser Lys Leu Phe Ile Arg Ser Pro Arg Thr Leu Val Thr Leu 
    450                 455                 460


Glu Gln Ser Arg Ala Arg Leu Ile Pro Ile Ile Val Leu Leu Leu Gln 
465                 470                 475                 480


Lys Ala Trp Arg Gly Thr Leu Ala Arg Trp Arg Cys Arg Arg Leu Arg 
                485                 490                 495


Ala Ile Tyr Thr Ile Met Arg Trp Phe Arg Arg His Lys Val Arg Ala 
            500                 505                 510


His Leu Ala Glu Leu Gln Arg Arg Phe Gln Ala Ala Arg Gln Pro Pro 
        515                 520                 525


Leu Tyr Gly Arg Asp Leu Val Trp Pro Leu Pro Pro Ala Val Leu Gln 
    530                 535                 540


Pro Phe Gln Asp Thr Cys His Ala Leu Phe Cys Arg Trp Arg Ala Arg 
545                 550                 555                 560


Gln Leu Val Lys Asn Ile Pro Pro Ser Asp Met Pro Gln Ile Lys Ala 
                565                 570                 575


Lys Val Ala Ala Met Gly Ala Leu Gln Gly Leu Arg Gln Asp Trp Gly 
            580                 585                 590


Cys Arg Arg Ala Trp Ala Arg Asp Tyr Leu Ser Ser Ala Thr Asp Asn 
        595                 600                 605


Pro Thr Ala Ser Ser Leu Phe Ala Gln Arg Leu Lys Thr Leu Gln Asp 
    610                 615                 620


Lys Asp Gly Phe Gly Ala Val Leu Phe Ser Ser His Val Arg Lys Val 
625                 630                 635                 640


Asn Arg Phe His Lys Ile Arg Asn Arg Ala Leu Leu Leu Thr Asp Gln 
                645                 650                 655


His Leu Tyr Lys Leu Asp Pro Asp Arg Gln Tyr Arg Val Met Arg Ala 
            660                 665                 670


Val Pro Leu Glu Ala Val Thr Gly Leu Ser Val Thr Ser Gly Gly Asp 
        675                 680                 685


Gln Leu Val Val Leu His Ala Arg Gly Gln Asp Asp Leu Val Val Cys 
    690                 695                 700


Leu His Arg Ser Arg Pro Pro Leu Asp Asn Arg Val Gly Glu Leu Val 
705                 710                 715                 720


Gly Val Leu Ala Ala His Cys Gln Gly Glu Gly Arg Thr Leu Glu Val 
                725                 730                 735


Arg Val Ser Asp Cys Ile Pro Leu Ser His Arg Gly Val Arg Arg Leu 
            740                 745                 750


Ile Ser Val Glu Pro Arg Pro Glu Gln Pro Glu Pro Asp Phe Arg Cys 
        755                 760                 765


Ala Arg Gly Ser Phe Thr Leu Leu Trp Pro Ser Arg 
    770                 775                 780


<210>  3670
<211>  3063
<212>  DNA
<213>  Homo sapiens

<400>  3670
actttacacc agcactggag gaggctggtg gggcagggcg ggggcggtgg ggcctcccct     60

agccttccct ccccctctcc ttcactgtcc ttccagcagg cacaggaagg tgaggcaagg    120

tgtttccagc cggcaggatg gaggacgagg aaggccctga gtatggcaaa cctgactttg    180

tgcttttgga ccaagtgacc atggaggact tcatgaggaa cctgcagctc aggggagagt    240

ggggcaggga agacagaagc cagtaagcac atcatgcagt acatcgctgc tgtcaccaat    300

ccaagccaga gggctgaggt ggagagggtc aaggacgtgc tgctcaagtc cacctgtgtg    360

ctggaggcct ttggcaatgc ccgcaccaac cgcaatcaca actccagccg ctttggcaag    420

tacatggaca tcaactttga cttcaagggg gacccgatcg gaggacacat ccacagctac    480

ctactggaga agtctcgggt cctcaagcag cacgtgggtg aaagaaactt ccacgccttc    540

taccaattgc tgagaggcag tgaggacaag cagctgcatg aactgcactt ggagagaaac    600

cctgctgtat acaatttcac acaccaggga gcaggactca acatgactgt gcacagtgcc    660

ttggacagtg atgagcagag ccaccaggca gtgaccgagg ccatgagggt catcggcttc    720

agtcctgaag aggtggagtc tgtgcatcgc atcctggctg ccatattgca cctgggaaac    780

atcgagtttg tggagacgga ggagggtggg ctgcagaagg agggcctggc agtggccgag    840

gaggcactgg tggaccatgt ggctgagctg acggccacac cccgggacct cgtgctccgc    900

tccctgctgg ctcgcacagt tgcctcggga ggcagggaac tcatagagaa gggccacact    960

gcagctgagg ccagctatgc ccgggatgcc tgtgccaagg cagtgtacca gcggctgttt   1020

gagtgggtgg tgaacaggat caacagtgtc atggaacccc ggggccggga tcctcggcgt   1080

gatggcaagg acacagtcat tggcgtgctg gacatctatg gcttcgaggt gtttcccgtc   1140

aacagtttcg agcagttctg catcaactac tgcaacgaga agctgcagca gctattcatc   1200

cagctcatcc tgaagcagga acaggaagag tacgagcgcg agggcatcac ctggcagagc   1260

gttgagtatt tcaacaacgc caccattgtg gatctggtgg agcggcccca ccgtggcatc   1320

ctggccgtgc tggacgaggc ctgcagctct gctggcacca tcactgaccg aatcttcctg   1380

cagaccctgg acatgcacca ccgccatcac ctacactaca ccagccgcca gctctgcccc   1440

acagacaaga ccatggagtt tggccgagac ttccggatca agcactatgc aggggacgtc   1500

acgtactccg tggaaggctt catcgacaag aacagagatt tcctcttcca ggacttcaag   1560

cggctgctgt acaacagcac ggaccccact ctacgggcca tgtggccgga cgggcagcag   1620

gacatcacag aggtgaccaa gcgccccctg acggctggca cactcttcaa gaactccatg   1680

gtggccctgg tggagaacct tgcctccaag gagcccttct acgtccgctg catcaagccc   1740

aatgaggaca aggtagctgg gaagctggat gagaaccact gtcgccacca ggtcgcatac   1800

ctggggctgc tggagaatgt gagggtccgc agggctggct tcgcttcccg ccagccctac   1860

tctcgattcc tgctcaggta caagatgacc tgtgaataca catggcccaa ccacctgctg   1920

ggctccgaca aggcagccgt gagcgctctc ctggagcagc acgggctgca gggggacgtg   1980

gcctttggcc acagcaagct gttcatccgc tcaccccgga cactggtcac actggagcag   2040

agccgagccc gcctcatccc catcattgtg ctgctattgc agaaggcatg gcggggcacc   2100

ttggcgaggt ggcgctgccg gaggctgagg gctatctaca ccatcatgcg ctggttccgg   2160

agacacaagg tgcgggctca cctggctgag ctgcagcggc gattccaggc tgcaaggcag   2220

ccgccactct acgggcgtga ccttgtgtgg ccgctgcccc ctgctgtgct gcagcccttc   2280

caggacacct gccacgcact cttctgcagg tggcgggccc ggcagctggt gaagaacatc   2340

cccccttcag acatgcccca gatcaaggcc aaggtggccg ccatgggggc cctgcaaggg   2400

cttcgtcagg actggggctg ccgacgggcc tgggcccgag actacctgtc ctctgccact   2460

gacaatccca cagcatcaag cctgtttgct cagcgactaa agacacttca ggacaaagat   2520

ggcttcgggg ctgtgctctt ttcaagccat gtccgcaagg tgaaccgctt ccacaagatc   2580

cggaaccggg ccctcctgct cacagaccag cacctctaca agctggaccc tgaccggcag   2640

taccgggtga tgcgggccgt gccccttgag gcggtgacgg ggctgagcgt gaccagcgga   2700

ggagaccagc tggtggtgct gcacgcccgc ggccaggacg acctcgtggt gtgcctgcac   2760

cgctcccggc cgccattgga caaccgcgtt ggggagctgg tgggcgtgct ggccgcacac   2820

tgccaggggg agggccgcac cctggaggtt cgcgtctccg actgcatccc actaagccat   2880

cgcggggtcc ggcgcctcat ctccgtggag cccaggccgg agcagccaga gcccgatttc   2940

cgctgcgctc gcggctcctt caccctgctc tggcccagcc gctgagcgcc cgcacccgcc   3000

gcaccccgag gccgccaatt gtccgccccg ccagcgctgc aaataaacct tctgagtcag   3060

ccc                                                                 3063


<210>  3671
<211>  903
<212>  PRT
<213>  Homo sapiens

<400>  3671

Met Gln Tyr Ile Ala Ala Val Thr Asn Pro Ser Gln Arg Ala Glu Val 
1               5                   10                  15


Glu Arg Val Lys Asp Val Leu Leu Lys Ser Thr Cys Val Leu Glu Ala 
            20                  25                  30


Phe Gly Asn Ala Arg Thr Asn Arg Asn His Asn Ser Ser Arg Phe Gly 
        35                  40                  45


Lys Tyr Met Asp Ile Asn Phe Asp Phe Lys Gly Asp Pro Ile Gly Gly 
    50                  55                  60


His Ile His Ser Tyr Leu Leu Glu Lys Ser Arg Val Leu Lys Gln His 
65                  70                  75                  80


Val Gly Glu Arg Asn Phe His Ala Phe Tyr Gln Leu Leu Arg Gly Ser 
                85                  90                  95


Glu Asp Lys Gln Leu His Glu Leu His Leu Glu Arg Asn Pro Ala Val 
            100                 105                 110


Tyr Asn Phe Thr His Gln Gly Ala Gly Leu Asn Met Thr Val His Ser 
        115                 120                 125


Ala Leu Asp Ser Asp Glu Gln Ser His Gln Ala Val Thr Glu Ala Met 
    130                 135                 140


Arg Val Ile Gly Phe Ser Pro Glu Glu Val Glu Ser Val His Arg Ile 
145                 150                 155                 160


Leu Ala Ala Ile Leu His Leu Gly Asn Ile Glu Phe Val Glu Thr Glu 
                165                 170                 175


Glu Gly Gly Leu Gln Lys Glu Gly Leu Ala Val Ala Glu Glu Ala Leu 
            180                 185                 190


Val Asp His Val Ala Glu Leu Thr Ala Thr Pro Arg Asp Leu Val Leu 
        195                 200                 205


Arg Ser Leu Leu Ala Arg Thr Val Ala Ser Gly Gly Arg Glu Leu Ile 
    210                 215                 220


Glu Lys Gly His Thr Ala Ala Glu Ala Ser Tyr Ala Arg Asp Ala Cys 
225                 230                 235                 240


Ala Lys Ala Val Tyr Gln Arg Leu Phe Glu Trp Val Val Asn Arg Ile 
                245                 250                 255


Asn Ser Val Met Glu Pro Arg Gly Arg Asp Pro Arg Arg Asp Gly Lys 
            260                 265                 270


Asp Thr Val Ile Gly Val Leu Asp Ile Tyr Gly Phe Glu Val Phe Pro 
        275                 280                 285


Val Asn Ser Phe Glu Gln Phe Cys Ile Asn Tyr Cys Asn Glu Lys Leu 
    290                 295                 300


Gln Gln Leu Phe Ile Gln Leu Ile Leu Lys Gln Glu Gln Glu Glu Tyr 
305                 310                 315                 320


Glu Arg Glu Gly Ile Thr Trp Gln Ser Val Glu Tyr Phe Asn Asn Ala 
                325                 330                 335


Thr Ile Val Asp Leu Val Glu Arg Pro His Arg Gly Ile Leu Ala Val 
            340                 345                 350


Leu Asp Glu Ala Cys Ser Ser Ala Gly Thr Ile Thr Asp Arg Ile Phe 
        355                 360                 365


Leu Gln Thr Leu Asp Met His His Arg His His Leu His Tyr Thr Ser 
    370                 375                 380


Arg Gln Leu Cys Pro Thr Asp Lys Thr Met Glu Phe Gly Arg Asp Phe 
385                 390                 395                 400


Arg Ile Lys His Tyr Ala Gly Asp Val Thr Tyr Ser Val Glu Gly Phe 
                405                 410                 415


Ile Asp Lys Asn Arg Asp Phe Leu Phe Gln Asp Phe Lys Arg Leu Leu 
            420                 425                 430


Tyr Asn Ser Thr Asp Pro Thr Leu Arg Ala Met Trp Pro Asp Gly Gln 
        435                 440                 445


Gln Asp Ile Thr Glu Val Thr Lys Arg Pro Leu Thr Ala Gly Thr Leu 
    450                 455                 460


Phe Lys Asn Ser Met Val Ala Leu Val Glu Asn Leu Ala Ser Lys Glu 
465                 470                 475                 480


Pro Phe Tyr Val Arg Cys Ile Lys Pro Asn Glu Asp Lys Val Ala Gly 
                485                 490                 495


Lys Leu Asp Glu Asn His Cys Arg His Gln Val Ala Tyr Leu Gly Leu 
            500                 505                 510


Leu Glu Asn Val Arg Val Arg Arg Ala Gly Phe Ala Ser Arg Gln Pro 
        515                 520                 525


Tyr Ser Arg Phe Leu Leu Arg Tyr Lys Met Thr Cys Glu Tyr Thr Trp 
    530                 535                 540


Pro Asn His Leu Leu Gly Ser Asp Lys Ala Ala Val Ser Ala Leu Leu 
545                 550                 555                 560


Glu Gln His Gly Leu Gln Gly Asp Val Ala Phe Gly His Ser Lys Leu 
                565                 570                 575


Phe Ile Arg Ser Pro Arg Thr Leu Val Thr Leu Glu Gln Ser Arg Ala 
            580                 585                 590


Arg Leu Ile Pro Ile Ile Val Leu Leu Leu Gln Lys Ala Trp Arg Gly 
        595                 600                 605


Thr Leu Ala Arg Trp Arg Cys Arg Arg Leu Arg Ala Ile Tyr Thr Ile 
    610                 615                 620


Met Arg Trp Phe Arg Arg His Lys Val Arg Ala His Leu Ala Glu Leu 
625                 630                 635                 640


Gln Arg Arg Phe Gln Ala Ala Arg Gln Pro Pro Leu Tyr Gly Arg Asp 
                645                 650                 655


Leu Val Trp Pro Leu Pro Pro Ala Val Leu Gln Pro Phe Gln Asp Thr 
            660                 665                 670


Cys His Ala Leu Phe Cys Arg Trp Arg Ala Arg Gln Leu Val Lys Asn 
        675                 680                 685


Ile Pro Pro Ser Asp Met Pro Gln Ile Lys Ala Lys Val Ala Ala Met 
    690                 695                 700


Gly Ala Leu Gln Gly Leu Arg Gln Asp Trp Gly Cys Arg Arg Ala Trp 
705                 710                 715                 720


Ala Arg Asp Tyr Leu Ser Ser Ala Thr Asp Asn Pro Thr Ala Ser Ser 
                725                 730                 735


Leu Phe Ala Gln Arg Leu Lys Thr Leu Gln Asp Lys Asp Gly Phe Gly 
            740                 745                 750


Ala Val Leu Phe Ser Ser His Val Arg Lys Val Asn Arg Phe His Lys 
        755                 760                 765


Ile Arg Asn Arg Ala Leu Leu Leu Thr Asp Gln His Leu Tyr Lys Leu 
    770                 775                 780


Asp Pro Asp Arg Gln Tyr Arg Val Met Arg Ala Val Pro Leu Glu Ala 
785                 790                 795                 800


Val Thr Gly Leu Ser Val Thr Ser Gly Gly Asp Gln Leu Val Val Leu 
                805                 810                 815


His Ala Arg Gly Gln Asp Asp Leu Val Val Cys Leu His Arg Ser Arg 
            820                 825                 830


Pro Pro Leu Asp Asn Arg Val Gly Glu Leu Val Gly Val Leu Ala Ala 
        835                 840                 845


His Cys Gln Gly Glu Gly Arg Thr Leu Glu Val Arg Val Ser Asp Cys 
    850                 855                 860


Ile Pro Leu Ser His Arg Gly Val Arg Arg Leu Ile Ser Val Glu Pro 
865                 870                 875                 880


Arg Pro Glu Gln Pro Glu Pro Asp Phe Arg Cys Ala Arg Gly Ser Phe 
                885                 890                 895


Thr Leu Leu Trp Pro Ser Arg 
            900


<210>  3672
<211>  3719
<212>  DNA
<213>  Homo sapiens

<400>  3672
acttcctact ttacaccagc actggaggag gctggtgggg cagggcgggg gcggtggggc     60

ctcccctagc cttccctccc cctctccttc actgtccttc cagcaggcac aggaaggtga    120

ggcaaggtgt ttccagccgg caggatggag gacgaggaag gccctgagta tggcaaacct    180

gactttgtgc ttttggacca agtgaccatg gaggacttca tgaggaacct gcagctcagg    240

ttcgagaagg gccgcatcta cacctacatc ggtgaggtgc tggtgtccgt gaacccctac    300

caggagctgc ccctgtatgg gcctgaggcc atcgccaggt accagggccg tgagctctat    360

gagcggccac cccatctcta tgctgtggcc aacgccgcct acaaggcaat gaagcaccgg    420

tccagggaca cctgcatcgt catctcaggg gagagtgggg cagggaagac agaagccagt    480

aagcacatca tgcagtacat cgctgctgtc accaatccaa gccagagggc tgaggtggag    540

agggtcaagg acgtgctgct caagtccacc tgtgtgctgg aggcctttgg caatgcccgc    600

accaaccgca atcacaactc cagccgcttt ggcaagtaca tggacatcaa ctttgacttc    660

aagggggacc cgatcggagg acacatccac agctacctac tggagaagtc tcgggtcctc    720

aagcagcacg tgggtgaaag aaacttccac gccttctacc aaggggacat cctgggagct    780

tatttgtcta aaggatgcct gtgtcctcta gttgctgaga ggcagtgagg acaagcagct    840

gcatgaactg cacttggaga gaaaccctgc tgtatacaat ttcacacacc agggagcagg    900

actcaacatg actgtgcaca gtgccttgga cagtgatgag cagagccacc aggcagtgac    960

cgaggccatg agggtcatcg gcttcagtcc tgaagaggtg gagtctgtgc atcgcatcct   1020

ggctgccata ttgcacctgg gaaacatcga gtttgtggag acggaggagg gtgggctgca   1080

gaaggagggc ctggcagtgg ccgaggaggc actggtggac catgtggctg agctgacggc   1140

cacaccccgg gacctcgtgc tccgctccct gctggctcgc acagttgcct cgggaggcag   1200

ggaactcata gagaagggcc acactgcagc tgaggccagc tatgcccggg atgcctgtgc   1260

caaggcagtg taccagcggc tgtttgagtg ggtggtgaac aggatcaaca gtgtcatgga   1320

accccggggc cgggatcctc ggcgtgatgg caaggacaca gtcattggcg tgctggacat   1380

ctatggcttc gaggtgtttc ccgtcaacag tttcgagcag ttctgcatca actactgcaa   1440

cgagaagctg cagcagctat tcatccagct catcctgaag caggaacagg aagagtacga   1500

gcgcgagggc atcacctggc agagcgttga gtatttcaac aacgccacca ttgtggatct   1560

ggtggagcgg ccccaccgtg gcatcctggc cgtgctggac gaggcctgca gctctgctgg   1620

caccatcact gaccgaatct tcctgcagac cctggacatg caccaccgcc atcacctaca   1680

ctacaccagc cgccagctct gccccacaga caagaccatg gagtttggcc gagacttccg   1740

gatcaagcac tatgcagggg acgtcacgta ctccgtggaa ggcttcatcg acaagaacag   1800

agatttcctc ttccaggact tcaagcggct gctgtacaac agcacggacc ccactctacg   1860

ggccatgtgg ccggacgggc agcaggacat cacagaggtg accaagcgcc ccctgacggc   1920

tggcacactc ttcaagaact ccatggtggc cctggtggag aaccttgcct ccaaggagcc   1980

cttctacgtc cgctgcatca agcccaatga ggacaaggta gctgggaagc tggatgagaa   2040

ccactgtcgc caccaggtcg catacctggg gctgctggag aatgtgaggg tccgcagggc   2100

tggcttcgct tcccgccagc cctactctcg attcctgctc aggtactggc acctgacacc   2160

catcactcca tgggccatag tccctgtgtg gagtccaagg ggtaggagca gagggtcccc   2220

aaacagcacg tcgcaaacat cgatacaagc aggaaccagc acgctgctgg cctcaagaca   2280

ccaaaatatc tgggaagaca tgtgtgtgag cacatgcatg tggggacata caggtgggaa   2340

catgggtatg agggctgtgt gaggacatgt atgtgaggac atgtgtatgg gaagacatat   2400

gtgcacaggt gtcataagtg ctccaggaac acactctgta tccctgccat ctccccaggt   2460

gtggggtggg cagggtgggc tccatcatct ctcccccagg cctgggccac actgccctgt   2520

cctgtggtga caggtacaag atgacctgtg aatacacatg gcccaaccac ctgctgggct   2580

ccgacaaggc agccgtgagc gctctcctgg agcagcacgg gctgcagggg gacgtggcct   2640

ttggccacag caagctgttc atccgctcac cccggacact ggtcacactg gagcagagcc   2700

gagcccgcct catccccatc attgtgctgc tattgcagaa ggcatggcgg ggcaccttgg   2760

cgaggtggcg ctgccggagg ctgagggcta tctacaccat catgcgctgg ttccggagac   2820

acaaggtgcg ggctcacctg gctgagctgc agcggcgatt ccaggctgca aggcagccgc   2880

cactctacgg gcgtgacctt gtgtggccgc tgccccctgc tgtgctgcag cccttccagg   2940

acacctgcca cgcactcttc tgcaggtggc gggcccggca gctggtgaag aacatccccc   3000

cttcagacat gccccagatc aaggccaagg tggccgccat gggggccctg caagggcttc   3060

gtcaggactg gggctgccga cgggcctggg cccgagacta cctgtcctct gccactgaca   3120

atcccacagc atcaagcctg tttgctcagc gactaaagac acttcaggac aaagatggct   3180

tcggggctgt gctcttttca agccatgtcc gcaaggtgaa ccgcttccac aagatccgga   3240

accgggccct cctgctcaca gaccagcacc tctacaagct ggaccctgac cggcagtacc   3300

gggtgatgcg ggccgtgccc cttgaggcgg tgacggggct gagcgtgacc agcggaggag   3360

accagctggt ggtgctgcac gcccgcggcc aggacgacct cgtggtgtgc ctgcaccgct   3420

cccggccgcc attggacaac cgcgttgggg agctggtggg cgtgctggcc gcacactgcc   3480

agggggaggg ccgcaccctg gaggttcgcg tctccgactg catcccacta agccatcgcg   3540

gggtccggcg cctcatctcc gtggagccca ggccggagca gccagagccc gatttccgct   3600

gcgctcgcgg ctccttcacc ctgctctggc ccagccgctg agcgcccgca cccgccgcac   3660

cccgaggccg ccaattgtcc gccccgccag cgctgcaaat aaaccttctg agtcagccc    3719


<210>  3673
<211>  484
<212>  PRT
<213>  Homo sapiens

<400>  3673

Met Thr Val His Ser Ala Leu Asp Ser Asp Glu Gln Ser His Gln Ala 
1               5                   10                  15


Val Thr Glu Ala Met Arg Val Ile Gly Phe Ser Pro Glu Glu Val Glu 
            20                  25                  30


Ser Val His Arg Ile Leu Ala Ala Ile Leu His Leu Gly Asn Ile Glu 
        35                  40                  45


Phe Val Glu Thr Glu Glu Gly Gly Leu Gln Lys Glu Gly Leu Ala Val 
    50                  55                  60


Ala Glu Glu Ala Leu Val Asp His Val Ala Glu Leu Thr Ala Thr Pro 
65                  70                  75                  80


Arg Asp Leu Val Leu Arg Ser Leu Leu Ala Arg Thr Val Ala Ser Gly 
                85                  90                  95


Gly Arg Glu Leu Ile Glu Lys Gly His Thr Ala Ala Glu Ala Ser Tyr 
            100                 105                 110


Ala Arg Asp Ala Cys Ala Lys Ala Val Tyr Gln Arg Leu Phe Glu Trp 
        115                 120                 125


Val Val Asn Arg Ile Asn Ser Val Met Glu Pro Arg Gly Arg Asp Pro 
    130                 135                 140


Arg Arg Asp Gly Lys Asp Thr Val Ile Gly Val Leu Asp Ile Tyr Gly 
145                 150                 155                 160


Phe Glu Val Phe Pro Val Asn Ser Phe Glu Gln Phe Cys Ile Asn Tyr 
                165                 170                 175


Cys Asn Glu Lys Leu Gln Gln Leu Phe Ile Gln Leu Ile Leu Lys Gln 
            180                 185                 190


Glu Gln Glu Glu Tyr Glu Arg Glu Gly Ile Thr Trp Gln Ser Val Glu 
        195                 200                 205


Tyr Phe Asn Asn Ala Thr Ile Val Asp Leu Val Glu Arg Pro His Arg 
    210                 215                 220


Gly Ile Leu Ala Val Leu Asp Glu Ala Cys Ser Ser Ala Gly Thr Ile 
225                 230                 235                 240


Thr Asp Arg Ile Phe Leu Gln Thr Leu Asp Met His His Arg His His 
                245                 250                 255


Leu His Tyr Thr Ser Arg Gln Leu Cys Pro Thr Asp Lys Thr Met Glu 
            260                 265                 270


Phe Gly Arg Asp Phe Arg Ile Lys His Tyr Ala Gly Asp Val Thr Tyr 
        275                 280                 285


Ser Val Glu Gly Phe Ile Asp Lys Asn Arg Asp Phe Leu Phe Gln Asp 
    290                 295                 300


Phe Lys Arg Leu Leu Tyr Asn Ser Thr Asp Pro Thr Leu Arg Ala Met 
305                 310                 315                 320


Trp Pro Asp Gly Gln Gln Asp Ile Thr Glu Val Thr Lys Arg Pro Leu 
                325                 330                 335


Thr Ala Gly Thr Leu Phe Lys Asn Ser Met Val Ala Leu Val Glu Asn 
            340                 345                 350


Leu Ala Ser Lys Glu Pro Phe Tyr Val Arg Cys Ile Lys Pro Asn Glu 
        355                 360                 365


Asp Lys Val Ala Gly Lys Leu Asp Glu Asn His Cys Arg His Gln Val 
    370                 375                 380


Ala Tyr Leu Gly Leu Leu Glu Asn Val Arg Val Arg Arg Ala Gly Phe 
385                 390                 395                 400


Ala Ser Arg Gln Pro Tyr Ser Arg Phe Leu Leu Arg Tyr Trp His Leu 
                405                 410                 415


Thr Pro Ile Thr Pro Trp Ala Ile Val Pro Val Trp Ser Pro Arg Gly 
            420                 425                 430


Arg Ser Arg Gly Ser Pro Asn Ser Thr Ser Gln Thr Ser Ile Gln Ala 
        435                 440                 445


Gly Thr Ser Thr Leu Leu Ala Ser Arg His Gln Asn Ile Trp Glu Asp 
    450                 455                 460


Met Cys Val Ser Thr Cys Met Trp Gly His Thr Gly Gly Asn Met Gly 
465                 470                 475                 480


Met Arg Ala Val 



<210>  3674
<211>  3279
<212>  DNA
<213>  Homo sapiens

<400>  3674
acttcctact ttacaccagc actggaggag gctggtgggg cagggcgggg gcggtggggc     60

ctcccctagc cttccctccc cctctccttc actgtccttc cagcaggcac aggaaggtga    120

ggcaaggtgt ttccagccgg caggatggag gacgaggaag gccctgagta tggcaaacct    180

gactttgtgc ttttggacca agtgaccatg gaggacttca tgaggaacct gcagctcagg    240

ttcgagaagg gccgcatcta cacctacatc ggtgaggtgc tggtgtccgt gaacccctac    300

caggagctgc ccctgtatgg gcctgaggcc atcgccaggt accagggccg tgagctctat    360

gagcggccac cccatctcta tgctgtggcc aacgccgcct acaaggcaat gaagcaccgg    420

tccagggaca cctgcatcgt catctcaggg gagagtgggg cagggaagac agaagccagt    480

aagcacatca tgcagtacat cgctgctgtc accaatccaa gccagagggc tgaggtggag    540

agggtcaagg acgtgctgct caagtccacc tgtgtgctgg aggcctttgg caatgcccgc    600

accaaccgca atcacaactc cagccgcttt ggcaagtaca tggacatcaa ctttgacttc    660

aagggggacc cgatcggagg acacatccac agctacctac tggagaagtc tcgggtcctc    720

aagcagcacg tgggtgaaag aaacttccac gccttctacc aattgctgag aggcagtgag    780

gacaagcagc tgcatgaact gcacttggag agaaaccctg ctgtatacaa tttcacacac    840

cagggagcag gactcaacat gactgtgcac agtgccttgg acagtgatga gcagagccac    900

caggcagtga ccgaggccat gagggtcatc ggcttcagtc ctgaagaggt ggagtctgtg    960

catcgcatcc tggctgccat attgcacctg ggaaacatcg agtttgtgga gacggaggag   1020

ggtgggctgc agaaggaggg cctggcagtg gccgaggagg cactggtgga ccatgtggct   1080

gagctgacgg ccacaccccg ggacctcgtg ctccgctccc tgctggctcg cacagttgcc   1140

tcgggaggca gggaactcat agagaagggc cacactgcag ctgaggccag ctatgcccgg   1200

gatgcctgtg ccaaggcagt gtaccagcgg ctgtttgagt gggtggtgaa caggatcaac   1260

agtgtcatgg aaccccgggg ccgggatcct cggcgtgatg gcaaggacac agtcattggc   1320

gtgctggaca tctatggctt cgaggtgttt cccgtcaaca gtttcgagca gttctgcatc   1380

aactactgca acgagaagct gcagcagcta ttcatccagc tcatcctgaa gcaggaacag   1440

gaagagtacg agcgcgaggg catcacctgg cagagcgttg agtatttcaa caacgccacc   1500

attgtggatc tggtggagcg gccccaccgt ggcatcctgg ccgtgctgga cgaggcctgc   1560

agctctgctg gcaccatcac tgaccgaatc ttcctgcaga ccctggacat gcaccaccgc   1620

catcacctac actacaccag ccgccagctc tgccccacag acaagaccat ggagtttggc   1680

cgagacttcc ggatcaagca ctatgcaggg gacgtcacgt actccgtgga aggcttcatc   1740

gacaagaaca gagatttcct cttccaggac ttcaagcggc tgctgtacaa cagcacggac   1800

cccactctac gggccatgtg gccggacggg cagcaggaca tcacagaggt gaccaagcgc   1860

cccctgacgg ctggcacact cttcaagaac tccatggtgg ccctggtgga gaaccttgcc   1920

tccaaggagc ccttctacgt ccgctgcatc aagcccaatg aggacaaggt agctgggaag   1980

ctggatgaga accactgtcg ccaccaggtc gcatacctgg ggctgctgga gaatgtgagg   2040

gtccgcaggg ctggcttcgc ttcccgccag ccctactctc gattcctgct caggtacaag   2100

atgacctgtg aatacacatg gcccaaccac ctgctgggct ccgacaaggc agccgtgagc   2160

gctctcctgg agcagcacgg gctgcagggg gacgtggcct ttggccacag caagctgttc   2220

atccgctcac cccggacact ggtcacactg gagcagagcc gagcccgcct catccccatc   2280

attgtgctgc tattgcagaa ggcatggcgg ggcaccttgg cgaggtggcg ctgccggagg   2340

ctgagggcta tctacaccat catgcgctgg ttccggagac acaaggtgcg ggctcacctg   2400

gctgagctgc agcggcgatt ccaggctgca aggcagccgc cactctacgg gcgtgacctt   2460

gtgtggccgc tgccccctgc tgtgctgcag cccttccagg acacctgcca cgcactcttc   2520

tgcaggtggc gggcccggca gctggtgaag aacatccccc cttcagacat gccccagatc   2580

aaggccaagg tggccgccat gggggccctg caagggcttc gtcaggactg gggctgccga   2640

cgggcctggg cccgagacta cctgtcctct gccactgaca atcccacagc atcaagcctg   2700

tttgctcagc gactaaagac acttcaggac aaagatggct tcggggctgt gctcttttca   2760

agccatgtcc gcaaggtgaa ccgcttccac aagatccgga accgggccct cctgctcaca   2820

gaccagcacc tctacaagct ggaccctgac cggcagtacc gggtgatgcg ggccgtgccc   2880

cttgaggcgg tgacggggct gagcgtgacc agcggaggag accagctggt ggtgctgcac   2940

gcccgcggcc aggacgacct cgtggtgtgc ctgcaccgct cccggccgcc attggacaac   3000

cgcgttgggg agctggtggg cgtgctggcc gcacactgcc agggggaggg ccgcaccctg   3060

gaggttcgcg tctccgactg catcccacta agccatcgcg gggtccggcg cctcatctcc   3120

gtggagccca ggccggagca gccagagccc gatttccgct gcgctcgcgg ctccttcacc   3180

ctgctctggc ccagccgctg agcgcccgca cccgccgcac cccgaggccg ccaattgtcc   3240

gccccgccag cgctgcaaat aaaccttctg agtcagccc                          3279


<210>  3675
<211>  1018
<212>  PRT
<213>  Homo sapiens

<400>  3675

Met Glu Asp Glu Glu Gly Pro Glu Tyr Gly Lys Pro Asp Phe Val Leu 
1               5                   10                  15


Leu Asp Gln Val Thr Met Glu Asp Phe Met Arg Asn Leu Gln Leu Arg 
            20                  25                  30


Phe Glu Lys Gly Arg Ile Tyr Thr Tyr Ile Gly Glu Val Leu Val Ser 
        35                  40                  45


Val Asn Pro Tyr Gln Glu Leu Pro Leu Tyr Gly Pro Glu Ala Ile Ala 
    50                  55                  60


Arg Tyr Gln Gly Arg Glu Leu Tyr Glu Arg Pro Pro His Leu Tyr Ala 
65                  70                  75                  80


Val Ala Asn Ala Ala Tyr Lys Ala Met Lys His Arg Ser Arg Asp Thr 
                85                  90                  95


Cys Ile Val Ile Ser Gly Glu Ser Gly Ala Gly Lys Thr Glu Ala Ser 
            100                 105                 110


Lys His Ile Met Gln Tyr Ile Ala Ala Val Thr Asn Pro Ser Gln Arg 
        115                 120                 125


Ala Glu Val Glu Arg Val Lys Asp Val Leu Leu Lys Ser Thr Cys Val 
    130                 135                 140


Leu Glu Ala Phe Gly Asn Ala Arg Thr Asn Arg Asn His Asn Ser Ser 
145                 150                 155                 160


Arg Phe Gly Lys Tyr Met Asp Ile Asn Phe Asp Phe Lys Gly Asp Pro 
                165                 170                 175


Ile Gly Gly His Ile His Ser Tyr Leu Leu Glu Lys Ser Arg Val Leu 
            180                 185                 190


Lys Gln His Val Gly Glu Arg Asn Phe His Ala Phe Tyr Gln Leu Leu 
        195                 200                 205


Arg Gly Ser Glu Asp Lys Gln Leu His Glu Leu His Leu Glu Arg Asn 
    210                 215                 220


Pro Ala Val Tyr Asn Phe Thr His Gln Gly Ala Gly Leu Asn Met Thr 
225                 230                 235                 240


Val His Ser Ala Leu Asp Ser Asp Glu Gln Ser His Gln Ala Val Thr 
                245                 250                 255


Glu Ala Met Arg Val Ile Gly Phe Ser Pro Glu Glu Val Glu Ser Val 
            260                 265                 270


His Arg Ile Leu Ala Ala Ile Leu His Leu Gly Asn Ile Glu Phe Val 
        275                 280                 285


Glu Thr Glu Glu Gly Gly Leu Gln Lys Glu Gly Leu Ala Val Ala Glu 
    290                 295                 300


Glu Ala Leu Val Asp His Val Ala Glu Leu Thr Ala Thr Pro Arg Asp 
305                 310                 315                 320


Leu Val Leu Arg Ser Leu Leu Ala Arg Thr Val Ala Ser Gly Gly Arg 
                325                 330                 335


Glu Leu Ile Glu Lys Gly His Thr Ala Ala Glu Ala Ser Tyr Ala Arg 
            340                 345                 350


Asp Ala Cys Ala Lys Ala Val Tyr Gln Arg Leu Phe Glu Trp Val Val 
        355                 360                 365


Asn Arg Ile Asn Ser Val Met Glu Pro Arg Gly Arg Asp Pro Arg Arg 
    370                 375                 380


Asp Gly Lys Asp Thr Val Ile Gly Val Leu Asp Ile Tyr Gly Phe Glu 
385                 390                 395                 400


Val Phe Pro Val Asn Ser Phe Glu Gln Phe Cys Ile Asn Tyr Cys Asn 
                405                 410                 415


Glu Lys Leu Gln Gln Leu Phe Ile Gln Leu Ile Leu Lys Gln Glu Gln 
            420                 425                 430


Glu Glu Tyr Glu Arg Glu Gly Ile Thr Trp Gln Ser Val Glu Tyr Phe 
        435                 440                 445


Asn Asn Ala Thr Ile Val Asp Leu Val Glu Arg Pro His Arg Gly Ile 
    450                 455                 460


Leu Ala Val Leu Asp Glu Ala Cys Ser Ser Ala Gly Thr Ile Thr Asp 
465                 470                 475                 480


Arg Ile Phe Leu Gln Thr Leu Asp Met His His Arg His His Leu His 
                485                 490                 495


Tyr Thr Ser Arg Gln Leu Cys Pro Thr Asp Lys Thr Met Glu Phe Gly 
            500                 505                 510


Arg Asp Phe Arg Ile Lys His Tyr Ala Gly Asp Val Thr Tyr Ser Val 
        515                 520                 525


Glu Gly Phe Ile Asp Lys Asn Arg Asp Phe Leu Phe Gln Asp Phe Lys 
    530                 535                 540


Arg Leu Leu Tyr Asn Ser Thr Asp Pro Thr Leu Arg Ala Met Trp Pro 
545                 550                 555                 560


Asp Gly Gln Gln Asp Ile Thr Glu Val Thr Lys Arg Pro Leu Thr Ala 
                565                 570                 575


Gly Thr Leu Phe Lys Asn Ser Met Val Ala Leu Val Glu Asn Leu Ala 
            580                 585                 590


Ser Lys Glu Pro Phe Tyr Val Arg Cys Ile Lys Pro Asn Glu Asp Lys 
        595                 600                 605


Val Ala Gly Lys Leu Asp Glu Asn His Cys Arg His Gln Val Ala Tyr 
    610                 615                 620


Leu Gly Leu Leu Glu Asn Val Arg Val Arg Arg Ala Gly Phe Ala Ser 
625                 630                 635                 640


Arg Gln Pro Tyr Ser Arg Phe Leu Leu Arg Tyr Lys Met Thr Cys Glu 
                645                 650                 655


Tyr Thr Trp Pro Asn His Leu Leu Gly Ser Asp Lys Ala Ala Val Ser 
            660                 665                 670


Ala Leu Leu Glu Gln His Gly Leu Gln Gly Asp Val Ala Phe Gly His 
        675                 680                 685


Ser Lys Leu Phe Ile Arg Ser Pro Arg Thr Leu Val Thr Leu Glu Gln 
    690                 695                 700


Ser Arg Ala Arg Leu Ile Pro Ile Ile Val Leu Leu Leu Gln Lys Ala 
705                 710                 715                 720


Trp Arg Gly Thr Leu Ala Arg Trp Arg Cys Arg Arg Leu Arg Ala Ile 
                725                 730                 735


Tyr Thr Ile Met Arg Trp Phe Arg Arg His Lys Val Arg Ala His Leu 
            740                 745                 750


Ala Glu Leu Gln Arg Arg Phe Gln Ala Ala Arg Gln Pro Pro Leu Tyr 
        755                 760                 765


Gly Arg Asp Leu Val Trp Pro Leu Pro Pro Ala Val Leu Gln Pro Phe 
    770                 775                 780


Gln Asp Thr Cys His Ala Leu Phe Cys Arg Trp Arg Ala Arg Gln Leu 
785                 790                 795                 800


Val Lys Asn Ile Pro Pro Ser Asp Met Pro Gln Ile Lys Ala Lys Val 
                805                 810                 815


Ala Ala Met Gly Ala Leu Gln Gly Leu Arg Gln Asp Trp Gly Cys Arg 
            820                 825                 830


Arg Ala Trp Ala Arg Asp Tyr Leu Ser Ser Ala Thr Asp Asn Pro Thr 
        835                 840                 845


Ala Ser Ser Leu Phe Ala Gln Arg Leu Lys Thr Leu Gln Asp Lys Asp 
    850                 855                 860


Gly Phe Gly Ala Val Leu Phe Ser Ser His Val Arg Lys Val Asn Arg 
865                 870                 875                 880


Phe His Lys Ile Arg Asn Arg Ala Leu Leu Leu Thr Asp Gln His Leu 
                885                 890                 895


Tyr Lys Leu Asp Pro Asp Arg Gln Tyr Arg Val Met Arg Ala Val Pro 
            900                 905                 910


Leu Glu Ala Val Thr Gly Leu Ser Val Thr Ser Gly Gly Asp Gln Leu 
        915                 920                 925


Val Val Leu His Ala Arg Gly Gln Asp Asp Leu Val Val Cys Leu His 
    930                 935                 940


Arg Ser Arg Pro Pro Leu Asp Asn Arg Val Gly Glu Leu Val Gly Val 
945                 950                 955                 960


Leu Ala Ala His Cys Gln Gly Glu Gly Arg Thr Leu Glu Val Arg Val 
                965                 970                 975


Ser Asp Cys Ile Pro Leu Ser His Arg Gly Val Arg Arg Leu Ile Ser 
            980                 985                 990


Val Glu Pro Arg Pro Glu Gln Pro Glu Pro Asp Phe Arg Cys Ala Arg 
        995                 1000                1005


Gly Ser Phe Thr Leu Leu Trp Pro Ser Arg 
    1010                1015


<210>  3676
<211>  2611
<212>  DNA
<213>  Homo sapiens

<400>  3676
acttcctact ttacaccagc actggaggag gctggtgggg cagggcgggg gcggtggggc     60

ctcccctagc cttccctccc cctctccttc actgtccttc cagcaggcac aggaaggtga    120

ggcaaggtgt ttccagccgg caggatggag gacgaggaag gccctgagta tggcaaacct    180

gactttgtgc ttttggacca agtgaccatg gaggacttca tgaggaacct gcagctcagg    240

ttcgagaagg gccgcatcta cacctacatc ggtgaggtgc tggtgtccgt gaacccctac    300

caggagctgc ccctgtatgg gcctgaggcc atcgccaggt accagggccg tgagctctat    360

gagcggccac cccatctcta tgctgtggcc aacgccgcct acaaggcaat gaagcaccgg    420

tccagggaca cctgcatcgt catctcaggg gagagtgggg cagggaagac agaagccagt    480

aagcacatca tgcagtacat cgctgctgtc accaatccaa gccagagggc tgaggtggag    540

agggtcaagg acgtgctgct caagtccacc tgtgtgctgg aggcctttgg caatgcccgc    600

accaaccgca atcacaactc cagccgcttt ggcaagtaca tggacatcaa ctttgacttc    660

aagggggacc cgatcggagg acacatccac agctacctac tggagaagtc tcgggtcctc    720

aagcagcacg tgggtgaaag aaacttccac gccttctacc aattgctgag aggcagtgag    780

gacaagcagc tgcatgaact gcacttggag agaaaccctg ctgtatacaa tttcacacac    840

cagggagcag gactcaacat gactgtgcac agtgccttgg acagtgatga gcagagccac    900

caggcagtga ccgaggccat gagggtcatc ggcttcagtc ctgaagaggt ggagtctgtg    960

catcgcatcc tggctgccat attgcacctg ggaaacatcg agtttgtgga gacggaggag   1020

ggtgggctgc agaaggaggg cctggcagtg gccgaggagg cactggtgga ccatgtggct   1080

gagctgacgg ccacaccccg ggacctcgtg ctccgctccc tgctggctcg cacagttgcc   1140

tcgggaggca gggaactcat agagaagggc cacactgcag ctgaggccag ctatgcccgg   1200

gatgcctgtg ccaaggcagt gtaccagcgg ctgtttgagt gggtggtgaa caggatcaac   1260

agtgtcatgg aaccccgggg ccgggatcct cggcgtgatg gcaaggacac agtcattggc   1320

gtgctggaca tctatggctt cgaggtgttt cccgtcaaca gtttcgagca gttctgcatc   1380

aactactgca acgagaagct gcagcagcta ttcatccagc tcatcctgaa gcaggaacag   1440

gaagagtacg agcgcgaggg catcacctgg cagagcgttg agtatttcaa caacgccacc   1500

attgtggatc tggtggagcg gccccaccgt ggcatcctgg ccgtgctgga cgaggcctgc   1560

agctctgctg gcaccatcac tgaccgaatc ttcctgcaga ccctggacat gcaccaccgc   1620

catcacctac actacaccag ccgccagctc tgccccacag acaagaccat ggagtttggc   1680

cgagacttcc ggatcaagca ctatgcaggg gacgtcacgt aagggccccc tcccacccac   1740

atccctggct ttcccacagg caccatggca tgtgtcatgg ggcaggagcg cttcagggga   1800

gtggctcgga gacaggtgtt atggccactt ctgccacccc caccccttta agacactgaa   1860

acatgccgga cagcagattc acaagtgaag agcaggaaac agggtttgag gatagtggtt   1920

aaccatggct gcattcttct gggagccttt aaaaaatacc cacgtctcat gtctgggccc   1980

aaccctatac cagcatctgt ggggtggggg gcttcaggct ggtgatgtgg gggtggggag   2040

ggagtggaag gtgcaggggg gccaagattc tgcatttcta acaagctccc aggtgaggcc   2100

tcgctaccat acttggacca cgctcccagt gccaaagccc aggtgtcttc aggggttgtc   2160

atgatggcta ttaacttatg tgttgcttgc cgcatcccaa aacgatttaa ggtgactcac   2220

atcaaggtat aagtgtttca tgagaacttc tcaaggagag ggaatagaat agatgatgac   2280

aacaaagcag cccaatatca tctaccttta tctgttcgca aaatctacac ccatgaggtc   2340

gctcatgcct gtaaccccag cactttggga ggccaaagtg ggtggatcac ctgaggccaa   2400

gagttcgaga ccagcctggc caacatggca aaacctcatc tgtactaaaa atataaaaat   2460

tatccgggca cgatgacgcg tgcctgtaat gccagttgct cgggaggctg aggcacaaga   2520

actgcttgaa cctgggaggt agaggttgtg gcgaactgag atcgcaccac tgcactccag   2580

cctgggcaag agagtgagac tatttctcaa a                                  2611


<210>  3677
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  3677

Met Glu Asp Glu Glu Gly Pro Glu Tyr Gly Lys Pro Asp Phe Val Leu 
1               5                   10                  15


Leu Asp Gln Val Thr Met Glu Asp Phe Met Arg Asn Leu Gln Leu Arg 
            20                  25                  30


Phe Glu Lys Gly Arg Ile Tyr Thr Tyr Ile Gly Glu Val Leu Val Ser 
        35                  40                  45


Val Asn Pro Tyr Gln Glu Leu Pro Leu Tyr Gly Pro Glu Ala Ile Ala 
    50                  55                  60


Arg Tyr Gln Gly Arg Glu Leu Tyr Glu Arg Pro Pro His Leu Tyr Ala 
65                  70                  75                  80


Val Ala Asn Ala Ala Tyr Lys Ala Met Lys His Arg Ser Arg Asp Thr 
                85                  90                  95


Cys Ile Val Ile Ser Gly Glu Ser Gly Ala Gly Lys Thr Glu Ala Ser 
            100                 105                 110


Lys His Ile Met Gln Tyr Ile Ala Ala Val Thr Asn Pro Ser Gln Arg 
        115                 120                 125


Ala Glu Val Glu Arg Val Lys Asp Val Leu Leu Lys Ser Thr Cys Val 
    130                 135                 140


Leu Glu Ala Phe Gly Asn Ala Arg Thr Asn Arg Asn His Asn Ser Ser 
145                 150                 155                 160


Arg Phe Gly Lys Tyr Met Asp Ile Asn Phe Asp Phe Lys Gly Asp Pro 
                165                 170                 175


Ile Gly Gly His Ile His Ser Tyr Leu Leu Glu Lys Ser Arg Val Leu 
            180                 185                 190


Lys Gln His Val Gly Glu Arg Asn Phe His Ala Phe Tyr Gln Leu Leu 
        195                 200                 205


Arg Gly Ser Glu Asp Lys Gln Leu His Glu Leu His Leu Glu Arg Asn 
    210                 215                 220


Pro Ala Val Tyr Asn Phe Thr His Gln Gly Ala Gly Leu Asn Met Thr 
225                 230                 235                 240


Val His Ser Ala Leu Asp Ser Asp Glu Gln Ser His Gln Ala Val Thr 
                245                 250                 255


Glu Ala Met Arg Val Ile Gly Phe Ser Pro Glu Glu Val Glu Ser Val 
            260                 265                 270


His Arg Ile Leu Ala Ala Ile Leu His Leu Gly Asn Ile Glu Phe Val 
        275                 280                 285


Glu Thr Glu Glu Gly Gly Leu Gln Lys Glu Gly Leu Ala Val Ala Glu 
    290                 295                 300


Glu Ala Leu Val Asp His Val Ala Glu Leu Thr Ala Thr Pro Arg Asp 
305                 310                 315                 320


Leu Val Leu Arg Ser Leu Leu Ala Arg Thr Val Ala Ser Gly Gly Arg 
                325                 330                 335


Glu Leu Ile Glu Lys Gly His Thr Ala Ala Glu Ala Ser Tyr Ala Arg 
            340                 345                 350


Asp Ala Cys Ala Lys Ala Val Tyr Gln Arg Leu Phe Glu Trp Val Val 
        355                 360                 365


Asn Arg Ile Asn Ser Val Met Glu Pro Arg Gly Arg Asp Pro Arg Arg 
    370                 375                 380


Asp Gly Lys Asp Thr Val Ile Gly Val Leu Asp Ile Tyr Gly Phe Glu 
385                 390                 395                 400


Val Phe Pro Val Asn Ser Phe Glu Gln Phe Cys Ile Asn Tyr Cys Asn 
                405                 410                 415


Glu Lys Leu Gln Gln Leu Phe Ile Gln Leu Ile Leu Lys Gln Glu Gln 
            420                 425                 430


Glu Glu Tyr Glu Arg Glu Gly Ile Thr Trp Gln Ser Val Glu Tyr Phe 
        435                 440                 445


Asn Asn Ala Thr Ile Val Asp Leu Val Glu Arg Pro His Arg Gly Ile 
    450                 455                 460


Leu Ala Val Leu Asp Glu Ala Cys Ser Ser Ala Gly Thr Ile Thr Asp 
465                 470                 475                 480


Arg Ile Phe Leu Gln Thr Leu Asp Met His His Arg His His Leu His 
                485                 490                 495


Tyr Thr Ser Arg Gln Leu Cys Pro Thr Asp Lys Thr Met Glu Phe Gly 
            500                 505                 510


Arg Asp Phe Arg Ile Lys His Tyr Ala Gly Asp Val Thr 
        515                 520                 525


<210>  3678
<211>  5780
<212>  DNA
<213>  Homo sapiens

<400>  3678
acttcctact ttacaccagc actggaggag gctggtgggg cagggcgggg gcggtggggc     60

ctcccctagc cttccctccc cctctccttc actgtccttc cagcaggcac aggaaggtga    120

ggcaaggtgt ttccagccgg caggatggag gacgaggaag gccctgagta tggcaaacct    180

gactttgtgc ttttggacca agtgaccatg gaggacttca tgaggaacct gcagctcagg    240

ttcgagaagg gccgcatcta cacctacatc ggtgaggtgc tggtgtccgt gaacccctac    300

caggagctgc ccctgtatgg gcctgaggcc atcgccaggt accagggccg tgagctctat    360

gagcggccac cccatctcta tgctgtggcc aacgccgcct acaaggcaat gaagcaccgg    420

tccagggaca cctgcatcgt catctcaggg gagagtgggg cagggaagac agaagccagt    480

aagcacatca tgcagtacat cgctgctgtc accaatccaa gccagagggc tgaggtggag    540

agggtcaagg acgtgctgct caagtccacc tgtgtgctgg aggcctttgg caatgcccgc    600

accaaccgca atcacaactc cagccgcttt ggcaagtaca tggacatcaa ctttgacttc    660

aagggggacc cgatcggagg acacatccac agctacctac tggagaagtc tcgggtcctc    720

aagcagcacg tgggtgaaag aaacttccac gccttctacc aagtaagccc tgagggcaag    780

gggaggtgga aaaatggggt ggggaaaggg agggcagcaa gctggaccag cttgtgaccc    840

ttccatcact accccaattc cccctctctg cccactcaac cccacctagc ccatcgtcct    900

cactccccac cacactcacc ccaaccagta ccccacaccc cacaaacaag agggtgtgac    960

ttgcagggaa caaaagcagg atgtcccctt tatctgagac acctccagat gagggctctc   1020

tgggacccat aagtgtctct gtgaacaata agctccccac gaggtgggct tcccctggga   1080

ttacaggcag tgtctctagt ggtatcagag ctcaacactg aagtggtgct cctggggaca   1140

cgggcattga ctctgagcac ctctgtgaga taggcgcgcc cagggactgt ctccacaagc   1200

tttgacaccc cactgaggtg ggagctccct ggaaacaaac agtgtctctg cagtctcaga   1260

gcttgacact gaagtggagc tccctggcac gccagcggtg tgtttgcaaa ctgtggcctg   1320

cccactgtgt cctctggttc acagacagtg tttccacaga ctccgaactc ccccactgaa   1380

ctgggagcac cctatgactg gagcagtgtc tctagggact tggagctccc cactgagtta   1440

ggagttccct gcagcacaga catggtcccc accaactctc agctccccag tgcagtggga   1500

gctccctgga acacagcagt ttctccctgg tacacaggcg gtgtttccat ggattctgag   1560

ctctttactg aggtgggagc tccctgagac aagcacagtg tctcacagac tctgtgctcc   1620

ccatgagaca ggagctccct gggtagcggg cagggtctcc agggtctatg aaccgcccgc   1680

tgaggtggga gcctcctggg atgcaaggag tgcctttaag gactctgagc ttccatggtg   1740

tggtgctccc tgggacacgg cagtgtcttc acgactctga cttcccactg aagtcacact   1800

ctctgggaca cagcagtgtc tgtaaggact ctgaactcca ctgaggtggg agccccctgg   1860

gctgtctttc cagtgagtct gcactgaggt gggagctcac tgggaaacca gtagtgtctc   1920

tgtggactct gacctttatt tgaggtaaaa gctccctgag acactggcag tgtctccaca   1980

gactctgagc ctccccctgg tgggagcccc tgggaacaca gagggcgtct ccacagactc   2040

tgagctctca ctgaaatgaa gctccctggg actccggcag gatctccaca gactcttacc   2100

tccccactga aatgggagat tttgggacat gggcagggtc tccatggact cagagttccc   2160

ccattgaagg gggagttcgg tggcacatgg gcattgtctc taatgactct gagctcctgg   2220

ctgaggggat tgctccctgg gacgttgcca gggtctccac agactctgag ctccccatga   2280

ggtgggagct ccacaggatt tgggcagggt ctccatgaac tataaactct ccactgaggt   2340

gggagctccc tgggacacag agagtttttt tcagactctg aactcccatg aaatggagct   2400

ctttggagca tggacagtgt ctttaaggac tctgagctac ccaccgaggt gggagctcag   2460

tgggacatgt gaagcagtgt ctccacggac tctgggctgc ccactcaggt gggctgtgtc   2520

ttggacacag gcagtgtctc tatcaacttt gggctctgct ctgaggtaag agccccctgg   2580

gacaggggca ctatctcctt ggactttgaa ctcccaccaa agtggagctc actgggacag   2640

tggcaacgtc tccacggatt ctgagctccc gctgaagtgg agctccctgg gaatcagtca   2700

gtgtccaaga actctgagct tccctgaggt gggagccctc tggaacacaa ggagtgtcca   2760

cgcagactct gagtttccat gaagtagggc tgtctgggac actggcggtg tctctatggt   2820

ctctgagctc ctcacggagc tgggagctcc ctcggacatg ggcgatgtct ccacaaactc   2880

tccattcccc tatgaggtgg aagctctctg cgacatgacc attgtctctg tggaatctga   2940

gcttcccact agtgggagcc ccttgggaca cagggcaggg tctccacaga ctctaagctc   3000

ccactgaagt ggagctctct ggaataacag caggatctcc acagactctt accacctcca   3060

gtgaagtggg aacttttggg acacaggcag tgtctccatg gactctgagc tccctgctga   3120

ggtgggagtt catgtggcac cagttgtgtc tccacagacg ctgagctccc taggacatgg   3180

gctctccctg ggtggagagc aatgtctcca cggaacctgt gctccctact gaggtgggag   3240

cttcctggga caggggcagg gtctccagta actctgagct cccactgaag tggagctccc   3300

taggattctg cagtttgtcc acaaactctt acctcctcac tcagtgggag gttttgggac   3360

ccgggtagtg tctccacata ctctgagcta cccactgagg tgggatcccc ctgggtcgag   3420

ggcaatgtct ccacagggac tgagctccct accaagatga ggtctggcac aagaacagtg   3480

acttcatggt ggagtcatag ctcccactga agtggagctc cctgacccac tgaacagctg   3540

aatggggagc ttgctggcac acagaaactg ttcacactgt ctgaccttcc cccacgtttg   3600

ttcgttcaat actggaagga agcgcaagtc tgtttgttct cctgcctgtg tgtgtgtaca   3660

gggggacatc ctgggagctt atttgtctaa aggatgcctg tgtcctctag ttgctgagag   3720

gcagtgagga caagcagctg catgaactgc acttggagag aaaccctgct gtatacaatt   3780

tcacacacca gggagcagga ctcaacatga ctgtgcacag tgccttggac agtgatgagc   3840

agagccacca ggcagtgacc gaggccatga gggtcatcgg cttcagtcct gaagaggtgg   3900

agtctgtgca tcgcatcctg gctgccatat tgcacctggg aaacatcgag tttgtggaga   3960

cggaggaggg tgggctgcag aaggagggcc tggcagtggc cgaggaggca ctggtggacc   4020

atgtggctga gctgacggcc acaccccggg acctcgtgct ccgctccctg ctggctcgca   4080

cagttgcctc gggaggcagg gaactcatag agaagggcca cactgcagct gaggccagct   4140

atgcccggga tgcctgtgcc aaggcagtgt accagcggct gtttgagtgg gtggtgaaca   4200

ggatcaacag tgtcatggaa ccccggggcc gggatcctcg gcgtgatggc aaggacacag   4260

tcattggcgt gctggacatc tatggcttcg aggtgtttcc cgtcaacagt ttcgagcagt   4320

tctgcatcaa ctactgcaac gagaagctgc agcagctatt catccagctc atcctgaagc   4380

aggaacagga agagtacgag cgcgagggca tcacctggca gagcgttgag tatttcaaca   4440

acgccaccat tgtggatctg gtggagcggc cccaccgtgg catcctggcc gtgctggacg   4500

aggcctgcag ctctgctggc accatcactg accgaatctt cctgcagacc ctggacatgc   4560

accaccgcca tcacctacac tacaccagcc gccaggtgcc cccggctgtc ccagtgccac   4620

cacagtgggc tggtgggacc tgccccacag gcaccatgct gcccatgcct cgtggggcct   4680

ggttggggac ccagctttgg tgccattgtc gtcactgtgg caaccttctc tgccctggag   4740

gtggggaggc agggctatcc cttcatacag accctccaca taccttttgt gccttgacct   4800

cagcctgtcc ccatagctct gccccacaga caagaccatg gagtttggcc gagacttccg   4860

gatcaagcac tatgcagggg acgtcacgta agggccccct cccacccaca tccctggctt   4920

tcccacaggc accatggcat gtgtcatggg gcaggagcgc ttcaggggag tggctcggag   4980

acaggtgtta tggccacttc tgccaccccc acccctttaa gacactgaaa catgccggac   5040

agcagattca caagtgaaga gcaggaaaca gggtttgagg atagtggtta accatggctg   5100

cattcttctg ggagccttta aaaaataccc acgtctcatg tctgggccca accctatacc   5160

agcatctgtg gggtgggggg cttcaggctg gtgatgtggg ggtggggagg gagtggaagg   5220

tgcagggggg ccaagattct gcatttctaa caagctccca ggtgaggcct cgctaccata   5280

cttggaccac gctcccagtg ccaaagccca ggtgtcttca ggggttgtca tgatggctat   5340

taacttatgt gttgcttgcc gcatcccaaa acgatttaag gtgactcaca tcaaggtata   5400

agtgtttcat gagaacttct caaggagagg gaatagaata gatgatgaca acaaagcagc   5460

ccaatatcat ctacctttat ctgttcgcaa aatctacacc catgaggtcg ctcatgcctg   5520

taaccccagc actttgggag gccaaagtgg gtggatcacc tgaggccaag agttcgagac   5580

cagcctggcc aacatggcaa aacctcatct gtactaaaaa tataaaaatt atccgggcac   5640

gatgacgcgt gcctgtaatg ccagttgctc gggaggctga ggcacaagaa ctgcttgaac   5700

ctgggaggta gaggttgtgg cgaactgaga tcgcaccact gcactccagc ctgggcaaga   5760

gagtgagact atttctcaaa                                               5780


<210>  3679
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  3679

Met Thr Val His Ser Ala Leu Asp Ser Asp Glu Gln Ser His Gln Ala 
1               5                   10                  15


Val Thr Glu Ala Met Arg Val Ile Gly Phe Ser Pro Glu Glu Val Glu 
            20                  25                  30


Ser Val His Arg Ile Leu Ala Ala Ile Leu His Leu Gly Asn Ile Glu 
        35                  40                  45


Phe Val Glu Thr Glu Glu Gly Gly Leu Gln Lys Glu Gly Leu Ala Val 
    50                  55                  60


Ala Glu Glu Ala Leu Val Asp His Val Ala Glu Leu Thr Ala Thr Pro 
65                  70                  75                  80


Arg Asp Leu Val Leu Arg Ser Leu Leu Ala Arg Thr Val Ala Ser Gly 
                85                  90                  95


Gly Arg Glu Leu Ile Glu Lys Gly His Thr Ala Ala Glu Ala Ser Tyr 
            100                 105                 110


Ala Arg Asp Ala Cys Ala Lys Ala Val Tyr Gln Arg Leu Phe Glu Trp 
        115                 120                 125


Val Val Asn Arg Ile Asn Ser Val Met Glu Pro Arg Gly Arg Asp Pro 
    130                 135                 140


Arg Arg Asp Gly Lys Asp Thr Val Ile Gly Val Leu Asp Ile Tyr Gly 
145                 150                 155                 160


Phe Glu Val Phe Pro Val Asn Ser Phe Glu Gln Phe Cys Ile Asn Tyr 
                165                 170                 175


Cys Asn Glu Lys Leu Gln Gln Leu Phe Ile Gln Leu Ile Leu Lys Gln 
            180                 185                 190


Glu Gln Glu Glu Tyr Glu Arg Glu Gly Ile Thr Trp Gln Ser Val Glu 
        195                 200                 205


Tyr Phe Asn Asn Ala Thr Ile Val Asp Leu Val Glu Arg Pro His Arg 
    210                 215                 220


Gly Ile Leu Ala Val Leu Asp Glu Ala Cys Ser Ser Ala Gly Thr Ile 
225                 230                 235                 240


Thr Asp Arg Ile Phe Leu Gln Thr Leu Asp Met His His Arg His His 
                245                 250                 255


Leu His Tyr Thr Ser Arg Gln Val Pro Pro Ala Val Pro Val Pro Pro 
            260                 265                 270


Gln Trp Ala Gly Gly Thr Cys Pro Thr Gly Thr Met Leu Pro Met Pro 
        275                 280                 285


Arg Gly Ala Trp Leu Gly Thr Gln Leu Trp Cys His Cys Arg His Cys 
    290                 295                 300


Gly Asn Leu Leu Cys Pro Gly Gly Gly Glu Ala Gly Leu Ser Leu His 
305                 310                 315                 320


Thr Asp Pro Pro His Thr Phe Cys Ala Leu Thr Ser Ala Cys Pro His 
                325                 330                 335


Ser Ser Ala Pro Gln Thr Arg Pro Trp Ser Leu Ala Glu Thr Ser Gly 
            340                 345                 350


Ser Ser Thr Met Gln Gly Thr Ser Arg Lys Gly Pro Leu Pro Pro Thr 
        355                 360                 365


Ser Leu Ala Phe Pro Gln Ala Pro Trp His Val Ser Trp Gly Arg Ser 
    370                 375                 380


Ala Ser Gly Glu Trp Leu Gly Asp Arg Cys Tyr Gly His Phe Cys His 
385                 390                 395                 400


Pro His Pro Phe Lys Thr Leu Lys His Ala Gly Gln Gln Ile His Lys 
                405                 410                 415


<210>  3680
<211>  571
<212>  DNA
<213>  Homo sapiens

<400>  3680
ccgccatcct gggccccacg tgttgcctga ccattcctga gcccagtgtc catgaaactg     60

ggaggcgacc gtgttagctg ccagttcctg acagccacct ctcaccagtg gcttcactct    120

gtgtccctga cccagcacat ggcacaagag tgcctgccat ccgtcagtgt ttctacagca    180

gcaatcccaa gatgctggag ctagagggga cctgacctga gagaagatac cttcagtggc    240

tgccaggctg ttccttggaa cctgtgcagg gatgaggcct gcctgtgtta atacacctag    300

tgaggagtgg agctgaattt gaatgcaagc cttggcacct taattgagca agtttgaaac    360

ctcgcttgtt gcccttctgg aaggagtcag gaatttccag ttctgggcct gggctgtggg    420

tctggcagac agacctctgg ccctaggttt gggtgccagg ttctctgctt ccagaatgag    480

aagctttgct gtgcaccagg acctgggccc ttctggtatc tcctgaatga aaaacaaggg    540

atatttaata aatatggatt taaatatgtg a                                   571


<210>  3681
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  3681

Met Lys Leu Gly Gly Asp Arg Val Ser Cys Gln Phe Leu Thr Ala Thr 
1               5                   10                  15


Ser His Gln Trp Leu His Ser Val Ser Leu Thr Gln His Met Ala Gln 
            20                  25                  30


Glu Cys Leu Pro Ser Val Ser Val Ser Thr Ala Ala Ile Pro Arg Cys 
        35                  40                  45


Trp Ser 
    50


<210>  3682
<211>  721
<212>  DNA
<213>  Homo sapiens

<400>  3682
agtcttggct ggcagacctg tactccgtac tccgtacttc gtagtcgcag cggcgcggtc     60

ttcggcagtc tagtcatcca ccgccatcct gggccccacg tgttgcctga ccattcctga    120

gcccaggcca ggaatagttg ctgaacaccc caggcctgct gaggtccctc cttgagtctc    180

atgttcaagc agtctttgtc catgaaactg ggaggcgacc gtgttagctg ccagttcctg    240

acagccacct ctcaccagtg gcttcactct gtgtccctga cccagcacat ggcacaagag    300

tgcctgccat ccgtcagtgt ttctacagca gcaatcccaa gatgctggag ctagagggga    360

cctgacctga gagaagatac cttcagtggc tgccaggctg ttccttggaa cctgtgcagg    420

gatgaggcct gcctgtgtta atacacctag tgaggagtgg agctgaattt gaatgcaagc    480

cttggcacct taattgagca agtttgaaac ctcgcttgtt gcccttctgg aaggagtcag    540

gaatttccag ttctgggcct gggctgtggg tctggcagac agacctctgg ccctaggttt    600

gggtgccagg ttctctgctt ccagaatgag aagctttgct gtgcaccagg acctgggccc    660

ttctggtatc tcctgaatga aaaacaaggg atatttaata aatatggatt taaatatgtg    720

a                                                                    721


<210>  3683
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  3683

Met Phe Lys Gln Ser Leu Ser Met Lys Leu Gly Gly Asp Arg Val Ser 
1               5                   10                  15


Cys Gln Phe Leu Thr Ala Thr Ser His Gln Trp Leu His Ser Val Ser 
            20                  25                  30


Leu Thr Gln His Met Ala Gln Glu Cys Leu Pro Ser Val Ser Val Ser 
        35                  40                  45


Thr Ala Ala Ile Pro Arg Cys Trp Ser 
    50                  55


<210>  3684
<211>  734
<212>  DNA
<213>  Homo sapiens

<400>  3684
ggcgtcagtc ttggctggca gacctgtact ccgtactccg tacttcgtag tcgcagcggc     60

gcggtcttcg gcagtctagt catccaccgc catcctgggc cccacgtgtt gcctgaccat    120

tcctgagccc aggtgggagc cgtggctgag gtgacggtct caaagtggaa gagcttactg    180

tcacagcaac tcctttgcaa gatgccccgt gtccatgaaa ctgggaggcg accgtgttag    240

ctgccagttc ctgacagcca cctctcacca gtggcttcac tctgtgtccc tgacccagca    300

catggcacaa gagtgcctgc catccgtcag tgtttctaca gcagcaatcc caagatgctg    360

gagctagagg ggacctgacc tgagagaaga taccttcagt ggctgccagg ctgttccttg    420

gaacctgtgc agggatgagg cctgcctgtg ttaatacacc tagtgaggag tggagctgaa    480

tttgaatgca agccttggca ccttaattga gcaagtttga aacctcgctt gttgcccttc    540

tggaaggagt caggaatttc cagttctggg cctgggctgt gggtctggca gacagacctc    600

tggccctagg tttgggtgcc aggttctctg cttccagaat gagaagcttt gctgtgcacc    660

aggacctggg cccttctggt atctcctgaa tgaaaaacaa gggatattta ataaatatgg    720

atttaaatat gtga                                                      734


<210>  3685
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  3685

Met Lys Leu Gly Gly Asp Arg Val Ser Cys Gln Phe Leu Thr Ala Thr 
1               5                   10                  15


Ser His Gln Trp Leu His Ser Val Ser Leu Thr Gln His Met Ala Gln 
            20                  25                  30


Glu Cys Leu Pro Ser Val Ser Val Ser Thr Ala Ala Ile Pro Arg Cys 
        35                  40                  45


Trp Ser 
    50


<210>  3686
<211>  982
<212>  DNA
<213>  Homo sapiens

<400>  3686
tccactgagt tgacacgcag acgcagcctc aggaccctaa actctacgcc ccagcacacc     60

ctaccaagcg agcgcccgcg gccgcgtgac gtcatctacc ccaaacgctg tggccccggc    120

cacgcacggc ttcggggcgg gactacgcgg tgacgtcgag gtgcgcggcg cagcgcgcgg    180

cgtcagtctt ggctggcaga cctgtactcc gtactccgta cttcgtagtc gcagcggcgc    240

ggtcttcggc agtctagtca tccaccgcca tcctgggccc cacgtgttgc ctgaccattc    300

ctgagcccag gtgggagccg tggctgaggt gacggtctca aagtggaaga gcttactgtc    360

acagcaactc ctttgcaaga tgccccggcc aggaatagtt gctgaacacc ccaggcctgc    420

tgaggtccct ccttgagtct catgttcaag cagtctttgt ccatgaaact gggaggcgac    480

cgtgttagct gccagttcct gacagccacc tctcaccagt ggcttcactc tgtgtccctg    540

acccagcaca tggcacaaga gtgcctgcca tccgtcagtg tttctacagc agcaatccca    600

agatgctgga gctagagggg acctgacctg agagaagata ccttcagtgg ctgccaggct    660

gttccttgga acctgtgcag ggatgaggcc tgcctgtgtt aatacaccta gtgaggagtg    720

gagctgaatt tgaatgcaag ccttggcacc ttaattgagc aagtttgaaa cctcgcttgt    780

tgcccttctg gaaggagtca ggaatttcca gttctgggcc tgggctgtgg gtctggcaga    840

cagacctctg gccctaggtt tgggtgccag gttctctgct tccagaatga gaagctttgc    900

tgtgcaccag gacctgggcc cttctggtat ctcctgaatg aaaaacaagg gatatttaat    960

aaatatggat ttaaatatgt ga                                             982


<210>  3687
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  3687

Met Phe Lys Gln Ser Leu Ser Met Lys Leu Gly Gly Asp Arg Val Ser 
1               5                   10                  15


Cys Gln Phe Leu Thr Ala Thr Ser His Gln Trp Leu His Ser Val Ser 
            20                  25                  30


Leu Thr Gln His Met Ala Gln Glu Cys Leu Pro Ser Val Ser Val Ser 
        35                  40                  45


Thr Ala Ala Ile Pro Arg Cys Trp Ser 
    50                  55


<210>  3688
<211>  1248
<212>  DNA
<213>  Homo sapiens

<400>  3688
cattaggggc tcagcgcgtc cctccaggcc acgccgtcag gcctccgtcc ttttagctgt     60

aggggcagat tacgtaactc cagccttctg gtcactaaag gagggtaaca aagggcggtc    120

gagagactcc actgagttga cacgcagacg cagcctcagg accctaaact ctacgcccca    180

gcacacccta ccaagcgagc gcccgcggcc gcgtgacgtc atctacccca aacgctgtgg    240

ccccggccac gcacggcttc ggggcgggac tacgcggtga cgtcgaggtg cgcggcgcag    300

cgcgcggcgt cagtcttggc tggcagacct gtactccgta ctccgtactt cgtagtcgca    360

gcggcgcggt cttcggcagt ctagtcatcc accgccatcc tgggccccac gtgttgcctg    420

accattcctg agcccaggtg ggagccgtgg ctgaggtgac ggtctcaaag tggaagagct    480

tactgtcaca gcaactcctt tgcaagatgc cccggtaaat cacgttgcag agaccccaac    540

tctgccttcc tggaactagg cctgcgtttt ctctgaacca ttatttcatg gggaaaatga    600

aatctacttc atgtgcctgg tctacttact ccttcagaag tgatttctga gccgccagga    660

atagttgctg aacaccccag gcctgctgag gtccctcctt gagtctcatg ttcaagcagt    720

ctttgtccat gaaactggga ggcgaccgtg ttagctgcca gttcctgaca gccacctctc    780

accagtggct tcactctgtg tccctgaccc agcacatggc acaagagtgc ctgccatccg    840

tcagtgtttc tacagcagca atcccaagat gctggagcta gaggggacct gacctgagag    900

aagatacctt cagtggctgc caggctgttc cttggaacct gtgcagggat gaggcctgcc    960

tgtgttaata cacctagtga ggagtggagc tgaatttgaa tgcaagcctt ggcaccttaa   1020

ttgagcaagt ttgaaacctc gcttgttgcc cttctggaag gagtcaggaa tttccagttc   1080

tgggcctggg ctgtgggtct ggcagacaga cctctggccc taggtttggg tgccaggttc   1140

tctgcttcca gaatgagaag ctttgctgtg caccaggacc tgggcccttc tggtatctcc   1200

tgaatgaaaa acaagggata tttaataaat atggatttaa atatgtga                1248


<210>  3689
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  3689

Met Phe Lys Gln Ser Leu Ser Met Lys Leu Gly Gly Asp Arg Val Ser 
1               5                   10                  15


Cys Gln Phe Leu Thr Ala Thr Ser His Gln Trp Leu His Ser Val Ser 
            20                  25                  30


Leu Thr Gln His Met Ala Gln Glu Cys Leu Pro Ser Val Ser Val Ser 
        35                  40                  45


Thr Ala Ala Ile Pro Arg Cys Trp Ser 
    50                  55


<210>  3690
<211>  3224
<212>  DNA
<213>  Homo sapiens

<400>  3690
gtgcgcggcg cagcgcgcgg cgtcagtctt ggctggcaga cctgtactcc gtactccgta     60

cttcgtagtc gcagcggcgc ggtcttcggc agtctagtca tccaccgcca tcctgggccc    120

cacgtgttgc ctgaccattc ctgagcccag gtgggagccg tggctgaggt gacggtctca    180

aagtggaaga gcttactgtc acagcaactc ctttgcaaga tgccccggta aatcacgttg    240

cagagacccc aactctgcct tcctggaact aggcctgcgt tttctctgaa ccattatttc    300

atggggaaaa tgaaatctac ttcatgtgcc tggtctactt actccttcag aagtgatttc    360

tgagccgtaa gatacatgag aaaaaaatga aggggaaaag gcagtattta tattaactac    420

atgatgataa ggatgtttct ggtcacagtg aaaagccatg ctagaattgt agtgtcatag    480

aataatgtgg aagtttagtt cgtgttgtct gatctattta ataatttaat aaggttatct    540

cttccaagac accttccctt cttcctcagc cagaaaggat ctttccctga gagtcattag    600

tagctctggg ctcctggaac caagctcagg tgcctaattg aactctggtc tcttcccaca    660

gcccccagca gggactggtg cttagtgaga gtggactgcc agattccttg agtgtggggg    720

atttgggtga atgagggtag caagcctcca gcgtgcttgg gtctgcggtg accctatgca    780

ttccttcagt gcttgctaga acagttttga aacggtttga ggccttgccc tgctccatcc    840

agagcaaggt tatagaaatt tcagacaatg acttcctccc tcctggatct agtgtcctgg    900

gccttgtata gatccgtgcc atctaatgtg gtagccactt ggcacacatg attaaattaa    960

atttggagtt ttatttcatt ttcacactag ccacatttca gatgatcagt agccacaggt   1020

ggccagtggc taccatattg gaccgcacag attagagggc atttctgtcg ctgtggaagt   1080

tgttttggac aatgctggtg tgaaaggtga agggaatcct gagtgtttgc tgtgctccag   1140

gctcagtaca aattttattt tattatacac ttaaagcaaa agtcttataa aagttgagga   1200

tgaagccaag agtggtggta agggtaggag ttgaaacagt gaagaggaat aacagggaag   1260

agtcctgccc tgagagactc atggaatagg atatttacaa ggcaaagcaa agagaaccaa   1320

agtctcagtt ctgcagagga gctgagtgcc ccaggagcta gtggagggtg aggtcaatgt   1380

gtgctcatct taaaggaaaa actcatggaa gaggaaggtg ctaatgttga acacctattt   1440

tgcgccagac ctcttaattg ttttaaatct ttgaggtatc atcatgaggt cgtttttaag   1500

ttcagtacag atgaggggcc caaggtcaga attatgtgtc cagggttgcc cagccacaaa   1560

ccagcagatc agggtttgat gccaggcctc tctaaccctg catcctgagt ggaatataga   1620

agccggtggg aagtttggat gggaaggaga tggatgcctt caagttcttg tcttggtgtt   1680

aggtgtgtta aaggactggc tgggatgaga agagtgttgc tggcttgagc atagcacgag   1740

cagcacagct cctgtgttcc tctgggtggt ggggtcacct ctcttaaagg tagaggcttt   1800

cagctgattc tgtcttttca ggccaggaat agttgctgaa caccccaggc ctgctgaggt   1860

ccctccttga gtctcatgtt caagcagtct tgtgagtaaa gcactggcta ccccttttca   1920

cttactatct tttcaagcat gttctaccac cttggaaggt aagaggttag taccttcttc   1980

cagagcagag ggcaggcatt cttgctgtgc gttgtgaaag ggtagagtcc tgcgctcctt   2040

tcttgtagta gtccaatggc tcatgcaggt gcctctgact cccctatggg aactggggct   2100

tgggagggtg gtggaaaatg ctgatgctct ggctattgct attgttttga ataatcagtg   2160

gtcccttgtc cctaatcgag gaattttgta ttttctacca gtgtccatga aactgggagg   2220

cgaccgtgtt agctgccagt tcctgacagc cacctctcac cagtggcttc actctgtgtc   2280

cctgacccag cacatggcac aagagtgcct gccatccgtc agtgtttcta cagcagcaat   2340

cccaagatgc tggagctaga ggggacctga cctgagagaa gataccttca gtggctgcca   2400

ggctgttcct tggaacctgt gcaggggtaa gtgtgcagga aggtctgacc tggcaagtca   2460

cttcactcct gttttattta gagtcacctg gctaatgaaa agtattttga ccttcccgta   2520

tggtaagtca ggtgattgaa tcccagaaag gttcattgtc ttcaagctca caatactatt   2580

ttgggacaaa cagttgtcta gtgtttggac tcatgaaccc tgattcttga gggtggtatt   2640

ttactgcttt tgtgatttgg tttcaacata tatagtcttt tctccggagt taccttaggt   2700

cagtggccag tgtttcagcc cctggaaagg gcatgggctg ccactgaggt tggtcacagg   2760

cctctcagct catggtggga gtgggttcag gagttggtaa gtagggttca gttctgttgt   2820

tgccaccgat ggcaacaggg gtttgtaata atccctagtt gtgtcaatta tgtcacttaa   2880

ttttcacaac aggtctctga agtgtttctc atctcatttt tacagatgag gcctgcctgt   2940

gttaatacac ctagtgagga gtggagctga atttgaatgc aagccttggc accttaattg   3000

agcaagtttg aaacctcgct tgttgccctt ctggaaggag tcaggaattt ccagttctgg   3060

gcctgggctg tgggtctggc agacagacct ctggccctag gtttgggtgc caggttctct   3120

gcttccagaa tgagaagctt tgctgtgcac caggacctgg gcccttctgg tatctcctga   3180

atgaaaaaca agggatattt aataaatatg gatttaaata tgtg                    3224


<210>  3691
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  3691

Met Gln Val Pro Leu Thr Pro Leu Trp Glu Leu Gly Leu Gly Arg Val 
1               5                   10                  15


Val Glu Asn Ala Asp Ala Leu Ala Ile Ala Ile Val Leu Asn Asn Gln 
            20                  25                  30


Trp Ser Leu Val Pro Asn Arg Gly Ile Leu Tyr Phe Leu Pro Val Ser 
        35                  40                  45


Met Lys Leu Gly Gly Asp Arg Val Ser Cys Gln Phe Leu Thr Ala Thr 
    50                  55                  60


Ser His Gln Trp Leu His Ser Val Ser Leu Thr Gln His Met Ala Gln 
65                  70                  75                  80


Glu Cys Leu Pro Ser Val Ser Val Ser Thr Ala Ala Ile Pro Arg Cys 
                85                  90                  95


Trp Ser 



<210>  3692
<211>  1630
<212>  DNA
<213>  Homo sapiens

<400>  3692
gtgcgcggcg cagcgcgcgg cgtcagtctt ggctggcaga cctgtactcc gtactccgta     60

cttcgtagtc gcagcggcgc ggtcttcggc agtctagtca tccaccgcca tcctgggccc    120

cacgtgttgc ctgaccattc ctgagcccag gtgggagccg tggctgaggt gacggtctca    180

aagtggaaga gcttactgtc acagcaactc ctttgcaaga tgccccggcc aggaatagtt    240

gctgaacacc ccaggcctgc tgaggtccct ccttgagtct catgttcaag cagtcttgtg    300

agtaaagcac tggctacccc ttttcactta ctatcttttc aagcatgttc taccaccttg    360

gaaggtaaga ggttagtacc ttcttccaga gcagagggca ggcattcttg ctgtgcgttg    420

tgaaagggta gagtcctgcg ctcctttctt gtagtagtcc aatggctcat gcaggtgcct    480

ctgactcccc tatgggaact ggggcttggg agggtggtgg aaaatgctga tgctctggct    540

attgctattg ttttgaataa tcagtggtcc cttgtcccta atcgaggaat tttgtatttt    600

ctaccagtgt ccatgaaact gggaggcgac cgtgttagct gccagttcct gacagccacc    660

tctcaccagt ggcttcactc tgtgtccctg acccagcaca tggcacaaga gtgcctgcca    720

tccgtcagtg tttctacagc agcaatccca agatgctgga gctagagggg acctgacctg    780

agagaagata ccttcagtgg ctgccaggct gttccttgga acctgtgcag gggtaagtgt    840

gcaggaaggt ctgacctggc aagtcacttc actcctgttt tatttagagt cacctggcta    900

atgaaaagta ttttgacctt cccgtatggt aagtcaggtg attgaatccc agaaaggttc    960

attgtcttca agctcacaat actattttgg gacaaacagt tgtctagtgt ttggactcat   1020

gaaccctgat tcttgagggt ggtattttac tgcttttgtg atttggtttc aacatatata   1080

gtcttttctc cggagttacc ttaggtcagt ggccagtgtt tcagcccctg gaaagggcat   1140

gggctgccac tgaggttggt cacaggcctc tcagctcatg gtgggagtgg gttcaggagt   1200

tggtaagtag ggttcagttc tgttgttgcc accgatggca acaggggttt gtaataatcc   1260

ctagttgtgt caattatgtc acttaatttt cacaacaggt ctctgaagtg tttctcatct   1320

catttttaca gatgaggcct gcctgtgtta atacacctag tgaggagtgg agctgaattt   1380

gaatgcaagc cttggcacct taattgagca agtttgaaac ctcgcttgtt gcccttctgg   1440

aaggagtcag gaatttccag ttctgggcct gggctgtggg tctggcagac agacctctgg   1500

ccctaggttt gggtgccagg ttctctgctt ccagaatgag aagctttgct gtgcaccagg   1560

acctgggccc ttctggtatc tcctgaatga aaaacaaggg atatttaata aatatggatt   1620

taaatatgtg                                                          1630


<210>  3693
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  3693

Met Gln Val Pro Leu Thr Pro Leu Trp Glu Leu Gly Leu Gly Arg Val 
1               5                   10                  15


Val Glu Asn Ala Asp Ala Leu Ala Ile Ala Ile Val Leu Asn Asn Gln 
            20                  25                  30


Trp Ser Leu Val Pro Asn Arg Gly Ile Leu Tyr Phe Leu Pro Val Ser 
        35                  40                  45


Met Lys Leu Gly Gly Asp Arg Val Ser Cys Gln Phe Leu Thr Ala Thr 
    50                  55                  60


Ser His Gln Trp Leu His Ser Val Ser Leu Thr Gln His Met Ala Gln 
65                  70                  75                  80


Glu Cys Leu Pro Ser Val Ser Val Ser Thr Ala Ala Ile Pro Arg Cys 
                85                  90                  95


Trp Ser 



<210>  3694
<211>  1657
<212>  DNA
<213>  Homo sapiens

<400>  3694
cattaggggc tcagcgcgtc cctccaggcc acgccgtcag gcctccgtcc ttttagctgt     60

aggggcagat tacgtaactc cagccttctg gtcactaaag gagggtaaca aagggcggtc    120

gagagactcc actgagttga cacgcagacg cagcctcagg accctaaact ctacgcccca    180

gcacacccta ccaagcgagc gcccgcggcc gcgtgacgtc atctacccca aacgctgtgg    240

ccccggccac gcacggcttc ggggcgggac tacgcggtga cgtcgaggtg cgcggcgcag    300

cgcgcggcgt cagtcttggc tggcagacct gtactccgta ctccgtactt cgtagtcgca    360

gcggcgcggt cttcggcagt ctagtcatcc accgccatcc tgggccccac gtgttgcctg    420

accattcctg agcccaggtg ggagccgtgg ctgaggtgac ggtctcaaag tggaagagct    480

tactgtcaca gcaactcctt tgcaagatgc cccggtaaat cacgttgcag agaccccaac    540

tctgccttcc tggaactagg cctgcgtttt ctctgaacca ttatttcatg gggaaaatga    600

aatctacttc atgtgcctgg tctacttact ccttcagaag tgatttctga gccgccagga    660

atagttgctg aacaccccag gcctgctgag gtccctcctt gagtctcatg ttcaagcagt    720

cttcacatgg cacaagagtg cctgccatcc gtcagtgttt ctacagcagc aatcccaaga    780

tgctggagct agaggggacc tgacctgaga gaagatacct tcagtggctg ccaggctgtt    840

ccttggaacc tgtgcagggg taagtgtgca ggaaggtctg acctggcaag tcacttcact    900

cctgttttat ttagagtcac ctggctaatg aaaagtattt tgaccttccc gtatggtaag    960

tcaggtgatt gaatcccaga aaggttcatt gtcttcaagc tcacaatact attttgggac   1020

aaacagttgt ctagtgtttg gactcatgaa ccctgattct tgagggtggt attttactgc   1080

ttttgtgatt tggtttcaac atatatagtc ttttctccgg agttacctta ggtcagtggc   1140

cagtgtttca gcccctggaa agggcatggg ctgccactga ggttggtcac aggcctctca   1200

gctcatggtg ggagtgggtt caggagttgg taagtagggt tcagttctgt tgttgccacc   1260

gatggcaaca ggggtttgta ataatcccta gttgtgtcaa ttatgtcact taattttcac   1320

aacaggtctc tgaagtgttt ctcatctcat ttttacagat gaggcctgcc tgtgttaata   1380

cacctagtga ggagtggagc tgaatttgaa tgcaagcctt ggcaccttaa ttgagcaagt   1440

ttgaaacctc gcttgttgcc cttctggaag gagtcaggaa tttccagttc tgggcctggg   1500

ctgtgggtct ggcagacaga cctctggccc taggtttggg tgccaggttc tctgcttcca   1560

gaatgagaag ctttgctgtg caccaggacc tgggcccttc tggtatctcc tgaatgaaaa   1620

acaagggata tttaataaat atggatttaa atatgtg                            1657


<210>  3695
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  3695

Met Phe Lys Gln Ser Ser His Gly Thr Arg Val Pro Ala Ile Arg Gln 
1               5                   10                  15


Cys Phe Tyr Ser Ser Asn Pro Lys Met Leu Glu Leu Glu Gly Thr 
            20                  25                  30


<210>  3696
<211>  3114
<212>  DNA
<213>  Homo sapiens

<400>  3696
agacctgtac tccgtactcc gtacttcgta gtcgcagcgg cgcggtcttc ggcagtctag     60

tcatccaccg ccatcctggg ccccacgtgt tgcctgacca ttcctgagcc caggtagggg    120

tcctggggga ttgggttcag tggcgggcgg cgtgggaggc tgggccgcag tgagtggggg    180

caccagtgat tcttggagac caagccttca ctacacgtgc tacttcctct caagaggcgg    240

ttgagcgcgt tcggaacatt ttacccggag gagactcggg gattacttga tgagtaacct    300

cgtgcttctc tttcagccga gaagtggggc ttctgcatga cctgggtgga ccccagtagg    360

tgggatggga cgtgtggtca ggagggacct caccggaagg catggggtgg cgtgtagacc    420

tgccgcaaga gaggctgtag agtgggccag gcgttgcaag gagctagagc tggataatgg    480

ttcagaggca caagctgaag ctaactgcgt ttggagctaa ctgcatttgt tcccttctag    540

gtgggagccg tggctgaggt gacggtctca aagtggaaga gcttactgtc acagcaactc    600

ctttgcaaga tgccccggta aatcacgttg cagagacccc aactctgcct tcctggaact    660

aggcctgcgt tttctctgaa ccattatttc atggggaaaa tgaaatctac ttcatgtgcc    720

tggtctactt actccttcag aagtgatttc tgagccgtaa gatacatgag aaaaaaatga    780

aggggaaaag gcagtattta tattaactac atgatgataa ggatgtttct ggtcacagtg    840

aaaagccatg ctagaattgt agtgtcatag aataatgtgg aagtttagtt cgtgttgtct    900

gatctattta ataatttaat aaggttatct cttccaagac accttccctt cttcctcagc    960

cagaaaggat ctttccctga gagtcattag tagctctggg ctcctggaac caagctcagg   1020

tgcctaattg aactctggtc tcttcccaca gcccccagca gggactggtg cttagtgaga   1080

gtggactgcc agattccttg agtgtggggg atttgggtga atgagggtag caagcctcca   1140

gcgtgcttgg gtctgcggtg accctatgca ttccttcagt gcttgctaga acagttttga   1200

aacggtttga ggccttgccc tgctccatcc agagcaaggt tatagaaatt tcagacaatg   1260

acttcctccc tcctggatct agtgtcctgg gccttgtata gatccgtgcc atctaatgtg   1320

gtagccactt ggcacacatg attaaattaa atttggagtt ttatttcatt ttcacactag   1380

ccacatttca gatgatcagt agccacaggt ggccagtggc taccatattg gaccgcacag   1440

attagagggc atttctgtcg ctgtggaagt tgttttggac aatgctggtg tgaaaggtga   1500

agggaatcct gagtgtttgc tgtgctccag gctcagtaca aattttattt tattatacac   1560

ttaaagcaaa agtcttataa aagttgagga tgaagccaag agtggtggta agggtaggag   1620

ttgaaacagt gaagaggaat aacagggaag agtcctgccc tgagagactc atggaatagg   1680

atatttacaa ggcaaagcaa agagaaccaa agtctcagtt ctgcagagga gctgagtgcc   1740

ccaggagcta gtggagggtg aggtcaatgt gtgctcatct taaaggaaaa actcatggaa   1800

gaggaaggtg ctaatgttga acacctattt tgcgccagac ctcttaattg ttttaaatct   1860

ttgaggtatc atcatgaggt cgtttttaag ttcagtacag atgaggggcc caaggtcaga   1920

attatgtgtc cagggttgcc cagccacaaa ccagcagatc agggtttgat gccaggcctc   1980

tctaaccctg catcctgagt ggaatataga agccggtggg aagtttggat gggaaggaga   2040

tggatgcctt caagttcttg tcttggtgtt aggtgtgtta aaggactggc tgggatgaga   2100

agagtgttgc tggcttgagc atagcacgag cagcacagct cctgtgttcc tctgggtggt   2160

ggggtcacct ctcttaaagg tagaggcttt cagctgattc tgtcttttca ggccaggaat   2220

agttgctgaa caccccaggc ctgctgaggt ccctccttga gtctcatgtt caagcagtct   2280

tgtgagtaaa gcactggcta ccccttttca cttactatct tttcaagcat gttctaccac   2340

cttggaaggt aagaggttag taccttcttc cagagcagag ggcaggcatt cttgctgtgc   2400

gttgtgaaag ggtagagtcc tgcgctcctt tcttgtagta gtccaatggc tcatgcaggt   2460

gcctctgact cccctatggg aactggggct tgggagggtg gtggaaaatg ctgatgctct   2520

ggctattgct attgttttga ataatcagtg gtcccttgtc cctaatcgag gaattttgta   2580

ttttctacca gtgtccatga aactgggagg cgaccgtgtt agctgccagt tcctgacagc   2640

cacctctcac cagtggcttc actctgtgtc cctgacccag cacatggcac aagagtgcct   2700

gccatccgtc agtgtttcta cagcagcaat cccaagatgc tggagctaga ggggacctga   2760

cctgagagaa gataccttca gtggctgcca ggctgttcct tggaacctgt gcagggatga   2820

ggcctgcctg tgttaataca cctagtgagg agtggagctg aatttgaatg caagccttgg   2880

caccttaatt gagcaagttt gaaacctcgc ttgttgccct tctggaagga gtcaggaatt   2940

tccagttctg ggcctgggct gtgggtctgg cagacagacc tctggcccta ggtttgggtg   3000

ccaggttctc tgcttccaga atgagaagct ttgctgtgca ccaggacctg ggcccttctg   3060

gtatctcctg aatgaaaaac aagggatatt taataaatat ggatttaaat atgt         3114


<210>  3697
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  3697

Met Gln Val Pro Leu Thr Pro Leu Trp Glu Leu Gly Leu Gly Arg Val 
1               5                   10                  15


Val Glu Asn Ala Asp Ala Leu Ala Ile Ala Ile Val Leu Asn Asn Gln 
            20                  25                  30


Trp Ser Leu Val Pro Asn Arg Gly Ile Leu Tyr Phe Leu Pro Val Ser 
        35                  40                  45


Met Lys Leu Gly Gly Asp Arg Val Ser Cys Gln Phe Leu Thr Ala Thr 
    50                  55                  60


Ser His Gln Trp Leu His Ser Val Ser Leu Thr Gln His Met Ala Gln 
65                  70                  75                  80


Glu Cys Leu Pro Ser Val Ser Val Ser Thr Ala Ala Ile Pro Arg Cys 
                85                  90                  95


Trp Ser 



<210>  3698
<211>  474
<212>  DNA
<213>  Homo sapiens

<400>  3698
gtcccgccga gagtctgggt gcggtgcggt tttctttttt cttgtgtccc actttattcc     60

ctgagccaca gggaatccgt tttctagtac ttctctgtta taaagtctgc ctgccttaga    120

caaacacatt tggaaaatag aagtgcaacc acaaggatgt gcagacccta tcagaataaa    180

atcgtagaac cttaccagtc atccggtata atttccacat tttccagatg aggtccgggg    240

aatgaggtga ttcgcccaaa agcacactac aaattggagt caccagcagg tctgctattt    300

tgccactaaa ccaatctgcc ggtcacacct tggctgtaaa gtgtcctaac agccacctac    360

ttatgattac tgctttctta ccaataacct ccccagcctg ttgtgtggct cctacatctt    420

gaacaaaagc gaccaaggca ggctcctgtt cattcccaag gctccgtgtc caca          474


<210>  3699
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  3699

Gln Pro Pro Thr Tyr Asp Tyr Cys Phe Leu Thr Asn Asn Leu Pro Ser 
1               5                   10                  15


Leu Leu Cys Gly Ser Tyr Ile Leu Asn Lys Ser Asp Gln Gly Arg Leu 
            20                  25                  30


Leu Phe Ile Pro Lys Ala Pro Cys 
        35                  40


<210>  3700
<211>  1829
<212>  DNA
<213>  Homo sapiens

<400>  3700
aggctgggaa gtcggccgcc gtaaagatgg cggcaaattg aaaaagttgg agctgctccc     60

gcgcgcgctc ccgcgcgcgc tgagtgggcg gagcgaacag ggggctggac agcctggaat    120

tgtctcgcca tttaaacgag tattcctaaa aggtgaaaag agtagagata agaaagccca    180

tgagaaggtg acagagaggc gccctctgca cactgtggtg ttgtcattgc ctgagcgcgt    240

cgagccagac agactgctga gcgactatat tgagaaggag gtaaagtatt taggtcagtt    300

aacgtccata ccaggatacc tgaatccctc cagtaggact gaaatcctgc atttcataga    360

caatgcaaag agagcccacc agcttccggg acacttgact caggagcacg atgctgtgct    420

cagcctgtct gcgtacaacg tcaagctggc ctggagggac ggggaggata tcatcctcag    480

ggtgcccatc catgacatcg ccgccgtctc ctatgttcgg gatgacgctg cacacctggt    540

ggtcctgaag acagcccagg acccagggat ctcccccagc cagagtctgt gtgcggaaag    600

ttccagaggc ctcagtgcag gctccctgtc ggagagtgca gttgggcccg tggaggcatg    660

ctgcctggtc atcctggctg cagagagcaa ggtcgctgcg gaggagcttt gctgtctgct    720

aggccaggtc ttccaggttg tttacacgga gtccaccatc gactttctgg acagagcgat    780

atttgatggg gcctctaccc cgacccacca cctgtccctg cacagcgatg actcttctac    840

aaaagtggac attaaggaga cctacgaggt ggaagccagc actttctgct tccctgaatc    900

tgtggatgtg ggtggtgcat caccccacag caagaccatc agtgagagcg agctgagcgc    960

cagcgccact gagctgctgc aggactacat gctgacgctg cgcaccaagc tgtcatcaca   1020

ggagatccag cagtttgcag cactgctgca cgagtaccgc aatggggcct ctatccacga   1080

gttctgcatc aacctgcggc agctctacgg ggacagccgc aagttcctgc tgcttggtct   1140

gaggcccttc atccctgaga aggacagcca gcacttcgag aacttcctgg agaccattgg   1200

cgtgaaggat ggccgcggca tcatcactga cagctttggc aggcaccggc gggccctgag   1260

caccacatcc agttccacca ccaatgggaa cagggccacg ggcagctctg atgaccggtc   1320

ggcaccctca gagggggatg agtgggaccg catgatctcg gacatcagca gcgacattga   1380

ggcgctgggc tgcagcatgg accaggactc agcatgatgg acagtggatg ggggggcacc   1440

cacaccttcc gcgcagtcgt cataggcctt cccagaagga gctgcccaga cctgcgtgtc   1500

agcccttggt ggtggccagg gagaggcgcc cggtgcagat ggccccgggc ggcccaggtc   1560

ctctactgtg aaggagcagg gagctgccga gggacacgag cctcagtgcg gggtggaagg   1620

ctctttgcct tgtccaccag ggctcagcca agccctgcag tgtgtccccg ctcggggagg   1680

gcccggccga gcgggcaggg agagccagtc ctgtcggctg ggcccttgga cggctgtcag   1740

ttttgcacat gatgttccta ttgtaactct cagagacctt aaaaagaagt ttactgcaat   1800

gtgaataatt taatctctgg ttgccaagc                                     1829


<210>  3701
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  3701

Met Leu Thr Leu Arg Thr Lys Leu Ser Ser Gln Glu Ile Gln Gln Phe 
1               5                   10                  15


Ala Ala Leu Leu His Glu Tyr Arg Asn Gly Ala Ser Ile His Glu Phe 
            20                  25                  30


Cys Ile Asn Leu Arg Gln Leu Tyr Gly Asp Ser Arg Lys Phe Leu Leu 
        35                  40                  45


Leu Gly Leu Arg Pro Phe Ile Pro Glu Lys Asp Ser Gln His Phe Glu 
    50                  55                  60


Asn Phe Leu Glu Thr Ile Gly Val Lys Asp Gly Arg Gly Ile Ile Thr 
65                  70                  75                  80


Asp Ser Phe Gly Arg His Arg Arg Ala Leu Ser Thr Thr Ser Ser Ser 
                85                  90                  95


Thr Thr Asn Gly Asn Arg Ala Thr Gly Ser Ser Asp Asp Arg Ser Ala 
            100                 105                 110


Pro Ser Glu Gly Asp Glu Trp Asp Arg Met Ile Ser Asp Ile Ser Ser 
        115                 120                 125


Asp Ile Glu Ala Leu Gly Cys Ser Met Asp Gln Asp Ser Ala 
    130                 135                 140


<210>  3702
<211>  465
<212>  DNA
<213>  Homo sapiens

<400>  3702
gggaagtcgg ccgccgtaaa gatggcggca aattgaaaaa gttggagctg ctcccgcgcg     60

cgctcccgcg cgcgctgagt gggcggagcg aacagggggc tggacagcct ggaattgtct    120

cgccatttaa acgagtattc ctaaaaggtg aaaagagtag agataagaaa gcccatgaga    180

aggtgacaga gaggcgccct ctgcacactg tggtgttgtc attgcctgag cgcgtcgagc    240

cagacagact gctgagcgac tatattgaga aggaggtaaa gtatttaggt cagttaacgt    300

ccataccagg atacctgaat ccctccagta ggactgaaat cctgcatttc atagacaatg    360

caaagagagc ccaccagctt ccgggacact tgactcagga gcacgatgct gtgctcagcc    420

tgtctgcgta caacgtcaag ctggcctgga gggacgggga ggata                    465


<210>  3703
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  3703

Glu Val Gly Arg Arg Lys Asp Gly Gly Lys Leu Lys Lys Leu Glu Leu 
1               5                   10                  15


Leu Pro Arg Ala Leu Pro Arg Ala Leu Ser Gly Arg Ser Glu Gln Gly 
            20                  25                  30


Ala Gly Gln Pro Gly Ile Val Ser Pro Phe Lys Arg Val Phe Leu Lys 
        35                  40                  45


Gly Glu Lys Ser Arg Asp Lys Lys Ala His Glu Lys Val Thr Glu Arg 
    50                  55                  60


Arg Pro Leu His Thr Val Val Leu Ser Leu Pro Glu Arg Val Glu Pro 
65                  70                  75                  80


Asp Arg Leu Leu Ser Asp Tyr Ile Glu Lys Glu Val Lys Tyr Leu Gly 
                85                  90                  95


Gln Leu Thr Ser Ile Pro Gly Tyr Leu Asn Pro Ser Ser Arg Thr Glu 
            100                 105                 110


Ile Leu His Phe Ile Asp Asn Ala Lys Arg Ala His Gln Leu Pro Gly 
        115                 120                 125


His Leu Thr Gln Glu His Asp Ala Val Leu Ser Leu Ser Ala Tyr Asn 
    130                 135                 140


Val Lys Leu Ala Trp Arg Asp Gly Glu 
145                 150


<210>  3704
<211>  1741
<212>  DNA
<213>  Homo sapiens

<400>  3704
ggcccggaag tgcgggtgtg gggcgcggcc ggggcggaga cttcgggccc ggctggcggg     60

cggcgccggg agcgcggggg cggcgggccc gggtcgagca tgtagcggct gctggcggcg    120

gggctcccgg ggcgggccgg gcgggccgcg ggagccgcac gcggcgatat ggaagaggag    180

ggcaagaagg gcaagaagta tttaggtcag ttaacgtcca taccaggata cctgaatccc    240

tccagtagga ctgaaatcct gcatttcata gacaatgcaa agagagccca ccagcttccg    300

ggacacttga ctcaggagca cgatgctgtg ctcagcctgt ctgcgtacaa cgtcaagctg    360

gcctggaggg acggggagga tatcatcctc agggtgccca tccatgacat cgccgccgtc    420

tcctatgttc gggatgacgc tgcacacctg gtggtcctga agacagccca ggacccaggg    480

atctccccca gccagagtct gtgtgcggaa agttccagag gcctcagtgc aggctccctg    540

tcggagagtg cagttgggcc cgtggaggca tgctgcctgg tcatcctggc tgcagagagc    600

aaggtcgctg cggaggagct ttgctgtctg ctaggccagg tcttccaggt tgtttacacg    660

gagtccacca tcgactttct ggacagagcg atatttgatg gggcctctac cccgacccac    720

cacctgtccc tgcacagcga tgactcttct acaaaagtgg acattaagga gacctacgag    780

gtggaagcca gcactttctg cttccctgaa tctgtggatg tgggtggtgc atcaccccac    840

agcaagacca tcagtgagag cgagctgagc gccagcgcca ctgagctgct gcaggactac    900

atgctgacgc tgcgcaccaa gctgtcatca caggagatcc agcagtttgc agcactgctg    960

cacgagtacc gcaatggggc ctctatccac gagttctgca tcaacctgcg gcagctctac   1020

ggggacagcc gcaagttcct gctgcttggt ctgaggccct tcatccctga gaaggacagc   1080

cagcacttcg agaacttcct ggagaccatt ggcgtgaagg atggccgcgg catcatcact   1140

gacagctttg gcaggcaccg gcgggccctg agcaccacat ccagttccac caccaatggg   1200

aacagggcca cgggcagctc tgatgaccgg tcggcaccct cagaggggga tgagtgggac   1260

cgcatgatct cggacatcag cagcgacatt gaggcgctgg gctgcagcat ggaccaggac   1320

tcagcatgat ggacagtgga tgggggggca cccacacctt ccgcgcagtc gtcataggcc   1380

ttcccagaag gagctgccca gacctgcgtg tcagcccttg gtggtggcca gggagaggcg   1440

cccggtgcag atggccccgg gcggcccagg tcctctactg tgaaggagca gggagctgcc   1500

gagggacacg agcctcagtg cggggtggaa ggctctttgc cttgtccacc agggctcagc   1560

caagccctgc agtgtgtccc cgctcgggga gggcccggcc gagcgggcag ggagagccag   1620

tcctgtcggc tgggcccttg gacggctgtc agttttgcac atgatgttcc tattgtaact   1680

ctcagagacc ttaaaaagaa gtttactgca atgtgaataa tttaatctct ggttgccaag   1740

c                                                                   1741


<210>  3705
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  3705

Met Glu Glu Glu Gly Lys Lys Gly Lys Lys Tyr Leu Gly Gln Leu Thr 
1               5                   10                  15


Ser Ile Pro Gly Tyr Leu Asn Pro Ser Ser Arg Thr Glu Ile Leu His 
            20                  25                  30


Phe Ile Asp Asn Ala Lys Arg Ala His Gln Leu Pro Gly His Leu Thr 
        35                  40                  45


Gln Glu His Asp Ala Val Leu Ser Leu Ser Ala Tyr Asn Val Lys Leu 
    50                  55                  60


Ala Trp Arg Asp Gly Glu Asp Ile Ile Leu Arg Val Pro Ile His Asp 
65                  70                  75                  80


Ile Ala Ala Val Ser Tyr Val Arg Asp Asp Ala Ala His Leu Val Val 
                85                  90                  95


Leu Lys Thr Ala Gln Asp Pro Gly Ile Ser Pro Ser Gln Ser Leu Cys 
            100                 105                 110


Ala Glu Ser Ser Arg Gly Leu Ser Ala Gly Ser Leu Ser Glu Ser Ala 
        115                 120                 125


Val Gly Pro Val Glu Ala Cys Cys Leu Val Ile Leu Ala Ala Glu Ser 
    130                 135                 140


Lys Val Ala Ala Glu Glu Leu Cys Cys Leu Leu Gly Gln Val Phe Gln 
145                 150                 155                 160


Val Val Tyr Thr Glu Ser Thr Ile Asp Phe Leu Asp Arg Ala Ile Phe 
                165                 170                 175


Asp Gly Ala Ser Thr Pro Thr His His Leu Ser Leu His Ser Asp Asp 
            180                 185                 190


Ser Ser Thr Lys Val Asp Ile Lys Glu Thr Tyr Glu Val Glu Ala Ser 
        195                 200                 205


Thr Phe Cys Phe Pro Glu Ser Val Asp Val Gly Gly Ala Ser Pro His 
    210                 215                 220


Ser Lys Thr Ile Ser Glu Ser Glu Leu Ser Ala Ser Ala Thr Glu Leu 
225                 230                 235                 240


Leu Gln Asp Tyr Met Leu Thr Leu Arg Thr Lys Leu Ser Ser Gln Glu 
                245                 250                 255


Ile Gln Gln Phe Ala Ala Leu Leu His Glu Tyr Arg Asn Gly Ala Ser 
            260                 265                 270


Ile His Glu Phe Cys Ile Asn Leu Arg Gln Leu Tyr Gly Asp Ser Arg 
        275                 280                 285


Lys Phe Leu Leu Leu Gly Leu Arg Pro Phe Ile Pro Glu Lys Asp Ser 
    290                 295                 300


Gln His Phe Glu Asn Phe Leu Glu Thr Ile Gly Val Lys Asp Gly Arg 
305                 310                 315                 320


Gly Ile Ile Thr Asp Ser Phe Gly Arg His Arg Arg Ala Leu Ser Thr 
                325                 330                 335


Thr Ser Ser Ser Thr Thr Asn Gly Asn Arg Ala Thr Gly Ser Ser Asp 
            340                 345                 350


Asp Arg Ser Ala Pro Ser Glu Gly Asp Glu Trp Asp Arg Met Ile Ser 
        355                 360                 365


Asp Ile Ser Ser Asp Ile Glu Ala Leu Gly Cys Ser Met Asp Gln Asp 
    370                 375                 380


Ser Ala 
385


<210>  3706
<211>  1893
<212>  DNA
<213>  Homo sapiens

<400>  3706
gcgcggccgg ggcggagact tcgggcccgg ctggcgggcg gcgccgggag cgcgggggcg     60

gcgggcccgg gtcgagcatg tagcggctgc tggcggcggg gctcccgggg cgggccgggc    120

gggccgcggg agccgcacgc ggcgatatgg aagaggaggg caagaagggc aagaagcctg    180

gaattgtctc gccatttaaa cgagtattcc taaaaggtga aaagagtaga gataagaaag    240

cccatgagaa ggtgacagag aggcgccctc tgcacactgt ggtgttgtca ttgcctgagc    300

gcgtcgagcc agacagactg ctgagcgact atattgagaa ggaggtaaag tatttaggtc    360

agttaacgtc cataccagga tacctgaatc cctccagtag gactgaaatc ctgcatttca    420

tagacaatgc aaagagagcc caccagcttc cgggacactt gactcaggag cacgatgctg    480

tgctcagcct gtctgcgtac aacgtcaagc tggcctggag ggacggggag gatatcatcc    540

tcagggtgcc catccatgac atcgccgccg tctcctatgt tcgggatgac gctgcacacc    600

tggtggtcct gaagacagcc caggacccag ggatctcccc cagccagagt ctgtgtgcgg    660

aaagttccag aggcctcagt gcaggctccc tgtcggagag tgcagttggg cccgtggagg    720

catgctgcct ggtcatcctg gctgcagaga gcaaggtcgc tgcggaggag ctttgctgtc    780

tgctaggcca ggtcttccag gttgtttaca cggagtccac catcgacttt ctggacagag    840

cgatatttga tggggcctct accccgaccc accacctgtc cctgcacagc gatgactctt    900

ctacaaaagt ggacattaag gagacctacg aggtggaagc cagcactttc tgcttccctg    960

aatctgtgga tgtgggtggt gcatcacccc acagcaagac catcagtgag agcgagctga   1020

gcgccagcgc cactgagctg ctgcaggact acatgctgac gctgcgcacc aagctgtcat   1080

cacaggagat ccagcagttt gcagcactgc tgcacgagta ccgcaatggg gcctctatcc   1140

acgagttctg catcaacctg cggcagctct acggggacag ccgcaagttc ctgctgcttg   1200

gtctgaggcc cttcatccct gagaaggaca gccagcactt cgagaacttc ctggagacca   1260

ttggcgtgaa ggatggccgc ggcatcatca ctgacagctt tggcaggcac cggcgggccc   1320

tgagcaccac atccagttcc accaccaatg ggaacagggc cacgggcagc tctgatgacc   1380

ggtcggcacc ctcagagggg gatgagtggg accgcatgat ctcggacatc agcagcgaca   1440

ttgaggcgct gggctgcagc atggaccagg actcagcatg atggacagtg gatggggggg   1500

cacccacacc ttccgcgcag tcgtcatagg ccttcccaga aggagctgcc cagacctgcg   1560

tgtcagccct tggtggtggc cagggagagg cgcccggtgc agatggcccc gggcggccca   1620

ggtcctctac tgtgaaggag cagggagctg ccgagggaca cgagcctcag tgcggggtgg   1680

aaggctcttt gccttgtcca ccagggctca gccaagccct gcagtgtgtc cccgctcggg   1740

gagggcccgg ccgagcgggc agggagagcc agtcctgtcg gctgggccct tggacggctg   1800

tcagttttgc acatgatgtt cctattgtaa ctctcagaga ccttaaaaag aagtttactg   1860

caatgtgaat aatttaatct ctggttgcca agc                                1893


<210>  3707
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  3707

Met Glu Glu Glu Gly Lys Lys Gly Lys Lys Pro Gly Ile Val Ser Pro 
1               5                   10                  15


Phe Lys Arg Val Phe Leu Lys Gly Glu Lys Ser Arg Asp Lys Lys Ala 
            20                  25                  30


His Glu Lys Val Thr Glu Arg Arg Pro Leu His Thr Val Val Leu Ser 
        35                  40                  45


Leu Pro Glu Arg Val Glu Pro Asp Arg Leu Leu Ser Asp Tyr Ile Glu 
    50                  55                  60


Lys Glu Val Lys Tyr Leu Gly Gln Leu Thr Ser Ile Pro Gly Tyr Leu 
65                  70                  75                  80


Asn Pro Ser Ser Arg Thr Glu Ile Leu His Phe Ile Asp Asn Ala Lys 
                85                  90                  95


Arg Ala His Gln Leu Pro Gly His Leu Thr Gln Glu His Asp Ala Val 
            100                 105                 110


Leu Ser Leu Ser Ala Tyr Asn Val Lys Leu Ala Trp Arg Asp Gly Glu 
        115                 120                 125


Asp Ile Ile Leu Arg Val Pro Ile His Asp Ile Ala Ala Val Ser Tyr 
    130                 135                 140


Val Arg Asp Asp Ala Ala His Leu Val Val Leu Lys Thr Ala Gln Asp 
145                 150                 155                 160


Pro Gly Ile Ser Pro Ser Gln Ser Leu Cys Ala Glu Ser Ser Arg Gly 
                165                 170                 175


Leu Ser Ala Gly Ser Leu Ser Glu Ser Ala Val Gly Pro Val Glu Ala 
            180                 185                 190


Cys Cys Leu Val Ile Leu Ala Ala Glu Ser Lys Val Ala Ala Glu Glu 
        195                 200                 205


Leu Cys Cys Leu Leu Gly Gln Val Phe Gln Val Val Tyr Thr Glu Ser 
    210                 215                 220


Thr Ile Asp Phe Leu Asp Arg Ala Ile Phe Asp Gly Ala Ser Thr Pro 
225                 230                 235                 240


Thr His His Leu Ser Leu His Ser Asp Asp Ser Ser Thr Lys Val Asp 
                245                 250                 255


Ile Lys Glu Thr Tyr Glu Val Glu Ala Ser Thr Phe Cys Phe Pro Glu 
            260                 265                 270


Ser Val Asp Val Gly Gly Ala Ser Pro His Ser Lys Thr Ile Ser Glu 
        275                 280                 285


Ser Glu Leu Ser Ala Ser Ala Thr Glu Leu Leu Gln Asp Tyr Met Leu 
    290                 295                 300


Thr Leu Arg Thr Lys Leu Ser Ser Gln Glu Ile Gln Gln Phe Ala Ala 
305                 310                 315                 320


Leu Leu His Glu Tyr Arg Asn Gly Ala Ser Ile His Glu Phe Cys Ile 
                325                 330                 335


Asn Leu Arg Gln Leu Tyr Gly Asp Ser Arg Lys Phe Leu Leu Leu Gly 
            340                 345                 350


Leu Arg Pro Phe Ile Pro Glu Lys Asp Ser Gln His Phe Glu Asn Phe 
        355                 360                 365


Leu Glu Thr Ile Gly Val Lys Asp Gly Arg Gly Ile Ile Thr Asp Ser 
    370                 375                 380


Phe Gly Arg His Arg Arg Ala Leu Ser Thr Thr Ser Ser Ser Thr Thr 
385                 390                 395                 400


Asn Gly Asn Arg Ala Thr Gly Ser Ser Asp Asp Arg Ser Ala Pro Ser 
                405                 410                 415


Glu Gly Asp Glu Trp Asp Arg Met Ile Ser Asp Ile Ser Ser Asp Ile 
            420                 425                 430


Glu Ala Leu Gly Cys Ser Met Asp Gln Asp Ser Ala 
        435                 440


<210>  3708
<211>  706
<212>  DNA
<213>  Homo sapiens

<400>  3708
gcggagactt cgggcccggc tggcgggcgg cgccgggagc gcgggggcgg cgggcccggg     60

tcgagcatgt agcggctgct ggcggcgggg ctcccggggc gggccgggcg ggccgcggga    120

gccgcacgcg gcgatatgga agaggagggc aagaagggca agaagtattt aggtcagtta    180

acgtccatac caggatacct gaatccctcc agtaggactg aaatcctgca tttcatagac    240

aatgcaaaga gagcccacca gcttccggga cacttgactc aggagcacga tgctgtgctc    300

agcctgtctg cgtacaacgt caagctggcc tggagggacg gggaggatat catcctcagg    360

gtgcccatcc atgacatcgc cgccgtctcc tatgttcggg atgacgctgc acacctggtg    420

gtcctgaaga cagcccagga cccagggatc tcccccagcc agagtctgtg tgcggaaagt    480

tccagaggcc tcagtgcagg ctccctgtcg gagagtgcag ttgggcccgt ggaggcatgc    540

tgcctggtca tcctggctgc agagagcaag gtcgctgcgg aggagctttg ctgtctgcta    600

ggccaggtct tccaggttgt ttacacggag tccaccatcg actttctgga cagagcgata    660

tttgatgggg cctctacccc gacccaccac ctgtccctgc acagcg                   706


<210>  3709
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  3709

Met Glu Glu Glu Gly Lys Lys Gly Lys Lys Tyr Leu Gly Gln Leu Thr 
1               5                   10                  15


Ser Ile Pro Gly Tyr Leu Asn Pro Ser Ser Arg Thr Glu Ile Leu His 
            20                  25                  30


Phe Ile Asp Asn Ala Lys Arg Ala His Gln Leu Pro Gly His Leu Thr 
        35                  40                  45


Gln Glu His Asp Ala Val Leu Ser Leu Ser Ala Tyr Asn Val Lys Leu 
    50                  55                  60


Ala Trp Arg Asp Gly Glu Asp Ile Ile Leu Arg Val Pro Ile His Asp 
65                  70                  75                  80


Ile Ala Ala Val Ser Tyr Val Arg Asp Asp Ala Ala His Leu Val Val 
                85                  90                  95


Leu Lys Thr Ala Gln Asp Pro Gly Ile Ser Pro Ser Gln Ser Leu Cys 
            100                 105                 110


Ala Glu Ser Ser Arg Gly Leu Ser Ala Gly Ser Leu Ser Glu Ser Ala 
        115                 120                 125


Val Gly Pro Val Glu Ala Cys Cys Leu Val Ile Leu Ala Ala Glu Ser 
    130                 135                 140


Lys Val Ala Ala Glu Glu Leu Cys Cys Leu Leu Gly Gln Val Phe Gln 
145                 150                 155                 160


Val Val Tyr Thr Glu Ser Thr Ile Asp Phe Leu Asp Arg Ala Ile Phe 
                165                 170                 175


Asp Gly Ala Ser Thr Pro Thr His His Leu Ser Leu His 
            180                 185


<210>  3710
<211>  1816
<212>  DNA
<213>  Homo sapiens

<400>  3710
ttcgggcccg gctggcgggc ggcgccggga gcgcgggggc ggcgggcccg ggtcgagcat     60

gtagcggctg ctggcggcgg ggctcccggg gcgggccggg cgggccgcgg gagccgcacg    120

cggcgatatg gaagaggagg gcaagaaggg caagaagcct ggaattgtct cgccatttaa    180

acgagtattc ctaaaaggtg aaaagagtag agataagaaa gcccatgaga aggtgacaga    240

gaggcgccct ctgcacactg tggtgttgtc attgcctgag cgcgtcgagc cagacagact    300

gctgagcgac tatattgaga aggaggtaaa gtatttaggt cagttaacgt ccataccagg    360

atacctgaat ccctccagta ggactgaaat cctgcatttc atagacaatg caaagagagc    420

ccaccagctt ccgggacact tgactcagga gcacgatgct gtgctcagcc tgtctgcgta    480

caacgtcaag ctggcctgga gggacgggga ggatatcatc ctcagggtgc ccatccatga    540

catcgccgcc gtctcctatg ttcgggatga cgctgcacac ctggtggtcc tgaagacagc    600

ccaggaccca gggatctccc ccagccagag tctgtgtgcg gaaagttcca gaggcctcag    660

tgcaggctcc ctgtcggaga gtgcagttgg gcccgtggag gcatgctgcc tggtcatcct    720

ggctgcagag agcaaggtcg ctgcggagga gctttgctgt ctgctaggcc aggtcttcca    780

ggttgtttac acggagtcca ccatcgactt tctggacaga gcgatatttg atggggcctc    840

taccccgacc caccacctgt ccctgcacag cgctgcttcc ctgaatctgt ggatgtgggt    900

ggtgcatcac cccacagcaa gaccatcagt gagagcgagc tgagcgccag cgccactgag    960

ctgctgcagg actacatgct gacgctgcgc accaagctgt catcacagga gatccagcag   1020

tttgcagcac tgctgcacga gtaccgcaat ggggcctcta tccacgagtt ctgcatcaac   1080

ctgcggcagc tctacgggga cagccgcaag ttcctgctgc ttggtctgag gcccttcatc   1140

cctgagaagg acagccagca cttcgagaac ttcctggaga ccattggcgt gaaggatggc   1200

cgcggcatca tcactgacag ctttggcagg caccggcggg ccctgagcac cacatccagt   1260

tccaccacca atgggaacag ggccacgggc agctctgatg accggtcggc accctcagag   1320

ggggatgagt gggaccgcat gatctcggac atcagcagcg acattgaggc gctgggctgc   1380

agcatggacc aggactcagc atgatggaca gtggatgggg gggcacccac accttccgcg   1440

cagtcgtcat aggccttccc agaaggagct gcccagacct gcgtgtcagc ccttggtggt   1500

ggccagggag aggcgcccgg tgcagatggc cccgggcggc ccaggtcctc tactgtgaag   1560

gagcagggag ctgccgaggg acacgagcct cagtgcgggg tggaaggctc tttgccttgt   1620

ccaccagggc tcagccaagc cctgcagtgt gtccccgctc ggggagggcc cggccgagcg   1680

ggcagggaga gccagtcctg tcggctgggc ccttggacgg ctgtcagttt tgcacatgat   1740

gttcctattg taactctcag agaccttaaa aagaagttta ctgcaatgtg aataatttaa   1800

tctctggttg ccaagc                                                   1816


<210>  3711
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  3711

Met Glu Glu Glu Gly Lys Lys Gly Lys Lys Pro Gly Ile Val Ser Pro 
1               5                   10                  15


Phe Lys Arg Val Phe Leu Lys Gly Glu Lys Ser Arg Asp Lys Lys Ala 
            20                  25                  30


His Glu Lys Val Thr Glu Arg Arg Pro Leu His Thr Val Val Leu Ser 
        35                  40                  45


Leu Pro Glu Arg Val Glu Pro Asp Arg Leu Leu Ser Asp Tyr Ile Glu 
    50                  55                  60


Lys Glu Val Lys Tyr Leu Gly Gln Leu Thr Ser Ile Pro Gly Tyr Leu 
65                  70                  75                  80


Asn Pro Ser Ser Arg Thr Glu Ile Leu His Phe Ile Asp Asn Ala Lys 
                85                  90                  95


Arg Ala His Gln Leu Pro Gly His Leu Thr Gln Glu His Asp Ala Val 
            100                 105                 110


Leu Ser Leu Ser Ala Tyr Asn Val Lys Leu Ala Trp Arg Asp Gly Glu 
        115                 120                 125


Asp Ile Ile Leu Arg Val Pro Ile His Asp Ile Ala Ala Val Ser Tyr 
    130                 135                 140


Val Arg Asp Asp Ala Ala His Leu Val Val Leu Lys Thr Ala Gln Asp 
145                 150                 155                 160


Pro Gly Ile Ser Pro Ser Gln Ser Leu Cys Ala Glu Ser Ser Arg Gly 
                165                 170                 175


Leu Ser Ala Gly Ser Leu Ser Glu Ser Ala Val Gly Pro Val Glu Ala 
            180                 185                 190


Cys Cys Leu Val Ile Leu Ala Ala Glu Ser Lys Val Ala Ala Glu Glu 
        195                 200                 205


Leu Cys Cys Leu Leu Gly Gln Val Phe Gln Val Val Tyr Thr Glu Ser 
    210                 215                 220


Thr Ile Asp Phe Leu Asp Arg Ala Ile Phe Asp Gly Ala Ser Thr Pro 
225                 230                 235                 240


Thr His His Leu Ser Leu His Ser Ala Ala Ser Leu Asn Leu Trp Met 
                245                 250                 255


Trp Val Val His His Pro Thr Ala Arg Pro Ser Val Arg Ala Ser 
            260                 265                 270


<210>  3712
<211>  860
<212>  DNA
<213>  Homo sapiens

<400>  3712
ggcgggcggc gccgggagcg cgggggcggc gggcccgggt cgagcatgta gcggctgctg     60

gcggcggggc tcccggggcg ggccgggcgg gccgcgggag ccgcacgcgg cgatatggaa    120

gaggagggca agaagggcaa gaagcctgga attgtctcgc catttaaacg agtattccta    180

aaaggtgaaa agagtagaga taagaaagcc catgagaagg tgacagagag gcgccctctg    240

cacactgtgg tgttgtcatt gcctgagcgc gtcgagccag acagactgct gagcgactat    300

attgagaagg aggtaaagta tttaggtcag ttaacgtcca taccaggata cctgaatccc    360

tccagtagga ctgaaatcct gcatttcata gacaatgcaa agagagccca ccagcttccg    420

ggacacttga ctcaggagca cgatgctgtg ctcagcctgt ctgcgtacaa cgtcaagctg    480

gcctggaggg acggggagga tatcatcctc agggtgccca tccatgacat cgccgccgtc    540

tcctatgttc gggatgacgc tgcacacctg gtggtcctga agacagccca ggacccaggg    600

atctccccca gccagagtct gtgtgcggaa agttccagag gcctcagtgc aggctccctg    660

tcggagagtg cagttgggcc cgtggaggca tgctgcctgg tcatcctggc tgcagagagc    720

aaggtcgctg cggaggagct ttgctgtctg ctaggccagg tcttccaggt tgtttacacg    780

gagtccacca tcgactttct ggacagagcg atatttgatg gggcctctac cccgacccac    840

cacctgtccc tgcacagcgg                                                860


<210>  3713
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  3713

Met Glu Glu Glu Gly Lys Lys Gly Lys Lys Pro Gly Ile Val Ser Pro 
1               5                   10                  15


Phe Lys Arg Val Phe Leu Lys Gly Glu Lys Ser Arg Asp Lys Lys Ala 
            20                  25                  30


His Glu Lys Val Thr Glu Arg Arg Pro Leu His Thr Val Val Leu Ser 
        35                  40                  45


Leu Pro Glu Arg Val Glu Pro Asp Arg Leu Leu Ser Asp Tyr Ile Glu 
    50                  55                  60


Lys Glu Val Lys Tyr Leu Gly Gln Leu Thr Ser Ile Pro Gly Tyr Leu 
65                  70                  75                  80


Asn Pro Ser Ser Arg Thr Glu Ile Leu His Phe Ile Asp Asn Ala Lys 
                85                  90                  95


Arg Ala His Gln Leu Pro Gly His Leu Thr Gln Glu His Asp Ala Val 
            100                 105                 110


Leu Ser Leu Ser Ala Tyr Asn Val Lys Leu Ala Trp Arg Asp Gly Glu 
        115                 120                 125


Asp Ile Ile Leu Arg Val Pro Ile His Asp Ile Ala Ala Val Ser Tyr 
    130                 135                 140


Val Arg Asp Asp Ala Ala His Leu Val Val Leu Lys Thr Ala Gln Asp 
145                 150                 155                 160


Pro Gly Ile Ser Pro Ser Gln Ser Leu Cys Ala Glu Ser Ser Arg Gly 
                165                 170                 175


Leu Ser Ala Gly Ser Leu Ser Glu Ser Ala Val Gly Pro Val Glu Ala 
            180                 185                 190


Cys Cys Leu Val Ile Leu Ala Ala Glu Ser Lys Val Ala Ala Glu Glu 
        195                 200                 205


Leu Cys Cys Leu Leu Gly Gln Val Phe Gln Val Val Tyr Thr Glu Ser 
    210                 215                 220


Thr Ile Asp Phe Leu Asp Arg Ala Ile Phe Asp Gly Ala Ser Thr Pro 
225                 230                 235                 240


Thr His His Leu Ser Leu His 
                245


<210>  3714
<211>  1577
<212>  DNA
<213>  Homo sapiens

<400>  3714
ccgggagcgc gggggcggcg ggcccgggtc gagcatgtag cggctgctgg cggcggggct     60

cccggggcgg gccgggcggg ccgcgggagc cgcacgcggc gatatggaag aggagggcaa    120

gaagggcaag aagcctggaa ttgtctcgcc atttaaacga gtattcctaa aaggtgaaaa    180

gagtagagat aagaaagccc atgagaaggt gacagagagg cgccctctgc acactgtggt    240

gttgtcattg cctgagcgcg tcgagccaga cagactgctg agcgactata ttgagaagga    300

ggtaaagtat ttaggtcagt taacgtccat accaggatac ctgaatccct ccagtaggac    360

tgaaatcctg catttcatag acaatgcaaa gagagcccac cagcttccgg gacacttgac    420

tcaggagcac gatgctgtgc tcagcctgtc tgcgtacaac gtcaagctgg cctggaggga    480

cggggaggat atcatcctca gggtgcccat ccatgacatc gccgccgtct cctatgttcg    540

ggatgacgct gcacacctgg tggtcctgaa gacagatgac tcttctacaa aagtggacat    600

taaggagacc tacgaggtgg aagccagcac tttctgcttc cctgaatctg tggatgtggg    660

tggtgcatca ccccacagca agaccatcag tgagagcgag ctgagcgcca gcgccactga    720

gctgctgcag gactacatgc tgacgctgcg caccaagctg tcatcacagg agatccagca    780

gtttgcagca ctgctgcacg agtaccgcaa tggggcctct atccacgagt tctgcatcaa    840

cctgcggcag ctctacgggg acagccgcaa gttcctgctg cttggtctga ggcccttcat    900

ccctgagaag gacagccagc acttcgagaa cttcctggag accattggcg tgaaggatgg    960

ccgcggcatc atcactgaca gctttggcag gcaccggcgg gccctgagca ccacatccag   1020

ttccaccacc aatgggaaca gggccacggg cagctctgat gaccggtcgg caccctcaga   1080

gggggatgag tgggaccgca tgatctcgga catcagcagc gacattgagg cgctgggctg   1140

cagcatggac caggactcag catgatggac agtggatggg ggggcaccca caccttccgc   1200

gcagtcgtca taggccttcc cagaaggagc tgcccagacc tgcgtgtcag cccttggtgg   1260

tggccaggga gaggcgcccg gtgcagatgg ccccgggcgg cccaggtcct ctactgtgaa   1320

ggagcaggga gctgccgagg gacacgagcc tcagtgcggg gtggaaggct ctttgccttg   1380

tccaccaggg ctcagccaag ccctgcagtg tgtccccgct cggggagggc ccggccgagc   1440

gggcagggag agccagtcct gtcggctggg cccttggacg gctgtcagtt ttgcacatga   1500

tgttcctatt gtaactctca gagaccttaa aaagaagttt actgcaatgt gaataattta   1560

atctctggtt gccaagc                                                  1577


<210>  3715
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  3715

Met Glu Glu Glu Gly Lys Lys Gly Lys Lys Pro Gly Ile Val Ser Pro 
1               5                   10                  15


Phe Lys Arg Val Phe Leu Lys Gly Glu Lys Ser Arg Asp Lys Lys Ala 
            20                  25                  30


His Glu Lys Val Thr Glu Arg Arg Pro Leu His Thr Val Val Leu Ser 
        35                  40                  45


Leu Pro Glu Arg Val Glu Pro Asp Arg Leu Leu Ser Asp Tyr Ile Glu 
    50                  55                  60


Lys Glu Val Lys Tyr Leu Gly Gln Leu Thr Ser Ile Pro Gly Tyr Leu 
65                  70                  75                  80


Asn Pro Ser Ser Arg Thr Glu Ile Leu His Phe Ile Asp Asn Ala Lys 
                85                  90                  95


Arg Ala His Gln Leu Pro Gly His Leu Thr Gln Glu His Asp Ala Val 
            100                 105                 110


Leu Ser Leu Ser Ala Tyr Asn Val Lys Leu Ala Trp Arg Asp Gly Glu 
        115                 120                 125


Asp Ile Ile Leu Arg Val Pro Ile His Asp Ile Ala Ala Val Ser Tyr 
    130                 135                 140


Val Arg Asp Asp Ala Ala His Leu Val Val Leu Lys Thr Asp Asp Ser 
145                 150                 155                 160


Ser Thr Lys Val Asp Ile Lys Glu Thr Tyr Glu Val Glu Ala Ser Thr 
                165                 170                 175


Phe Cys Phe Pro Glu Ser Val Asp Val Gly Gly Ala Ser Pro His Ser 
            180                 185                 190


Lys Thr Ile Ser Glu Ser Glu Leu Ser Ala Ser Ala Thr Glu Leu Leu 
        195                 200                 205


Gln Asp Tyr Met Leu Thr Leu Arg Thr Lys Leu Ser Ser Gln Glu Ile 
    210                 215                 220


Gln Gln Phe Ala Ala Leu Leu His Glu Tyr Arg Asn Gly Ala Ser Ile 
225                 230                 235                 240


His Glu Phe Cys Ile Asn Leu Arg Gln Leu Tyr Gly Asp Ser Arg Lys 
                245                 250                 255


Phe Leu Leu Leu Gly Leu Arg Pro Phe Ile Pro Glu Lys Asp Ser Gln 
            260                 265                 270


His Phe Glu Asn Phe Leu Glu Thr Ile Gly Val Lys Asp Gly Arg Gly 
        275                 280                 285


Ile Ile Thr Asp Ser Phe Gly Arg His Arg Arg Ala Leu Ser Thr Thr 
    290                 295                 300


Ser Ser Ser Thr Thr Asn Gly Asn Arg Ala Thr Gly Ser Ser Asp Asp 
305                 310                 315                 320


Arg Ser Ala Pro Ser Glu Gly Asp Glu Trp Asp Arg Met Ile Ser Asp 
                325                 330                 335


Ile Ser Ser Asp Ile Glu Ala Leu Gly Cys Ser Met Asp Gln Asp Ser 
            340                 345                 350


Ala 



<210>  3716
<211>  519
<212>  DNA
<213>  Homo sapiens

<400>  3716
cgcgggggcg gcgggcccgg gtcgagcatg tagcggctgc tggcggcggg gctcccgggg     60

cgggccgggc gggccgcggg agccgcacgc ggcgatatgg aagaggaggg caagaagggc    120

aagaagcctg gaattgtctc gccatttaaa cgagtattcc taaaaggtga aaagagtaga    180

gataagaaag cccatgagaa ggtgacagag aggcgccctc tgcacactgt ggtgttgtca    240

ttgcctgagc gcgtcgagcc agacagactg ctgagcgact atattgagaa ggaggtaaag    300

tatttaggtc agttaacgtc cataccagga tacctgaatc cctccagtag gactgaaatc    360

ctgcatttca tagacaatgc aaagagagcc caccagcttc cgggacactt gactcaggag    420

cacgatgctg tgctcagcct gtctgcgtac aacgtcaagc tggcctggag ggacggggag    480

gatatcatcc tcagggtgcc catccatgac atcgccgcc                           519


<210>  3717
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  3717

Met Glu Glu Glu Gly Lys Lys Gly Lys Lys Pro Gly Ile Val Ser Pro 
1               5                   10                  15


Phe Lys Arg Val Phe Leu Lys Gly Glu Lys Ser Arg Asp Lys Lys Ala 
            20                  25                  30


His Glu Lys Val Thr Glu Arg Arg Pro Leu His Thr Val Val Leu Ser 
        35                  40                  45


Leu Pro Glu Arg Val Glu Pro Asp Arg Leu Leu Ser Asp Tyr Ile Glu 
    50                  55                  60


Lys Glu Val Lys Tyr Leu Gly Gln Leu Thr Ser Ile Pro Gly Tyr Leu 
65                  70                  75                  80


Asn Pro Ser Ser Arg Thr Glu Ile Leu His Phe Ile Asp Asn Ala Lys 
                85                  90                  95


Arg Ala His Gln Leu Pro Gly His Leu Thr Gln Glu His Asp Ala Val 
            100                 105                 110


Leu Ser Leu Ser Ala Tyr Asn Val Lys Leu Ala Trp Arg Asp Gly Glu 
        115                 120                 125


Asp Ile Ile Leu Arg Val Pro Ile His Asp Ile Ala 
    130                 135                 140


<210>  3718
<211>  2849
<212>  DNA
<213>  Homo sapiens

<400>  3718
cccgggtcga gcatgtagcg gctgctggcg gcggggctcc cggggcgggc cgggcgggcc     60

gcgggagccg cacgcggcga tatggaagag gagggcaaga agggcaagaa gcctggaatt    120

gtctcgccat ttaaacgagt attcctaaaa ggtgaaaaga gtagagataa gaaagcccat    180

gagaaggtga cagagaggcg ccctctgcac actgtggtgt tgtcattgcc tgagcgcgtc    240

gagccagaca gactgctgag cgactatatt gagaaggagg taaagggctc ccattaatca    300

catattgata tttattttat ttttcatgcc ctttcatttt tctctcattt ttcctattct    360

ttactcttcc caatgccttc tgggaatgtt tcaaaccact ctccgtctta tgaattcatt    420

cctcaactgt attcattcaa ccctgaatta aattgtttgt ttctactata tctgattggt    480

ccttttttat aactccttgt ccctatttgt ttccagtgcc ctcctacatg cccttgagaa    540

tatttattag gattattgta aattcttgtt ttctctggct tatcagttct tctccctcca    600

gaattagttg tttagtttgt gatcttgcct ttccagtgct tgaggtctgt gttccacaga    660

tctgtcttta ttttttccat tccctccacc tgggtgacag agtgagactt tgcctcaaaa    720

aaacaaaaca aaacaaaaca aactcagaca aacaagatat gtttttgaac aatgaatatg    780

tggatatcaa aattaaatca ataccattca caatcactta aaaaatgaaa cacgggtata    840

aatcttacaa aacatgaata agatttgtat gctgaaaact atagaacact gatgaaagaa    900

atcaaagatc tgaataagtg gagagacaca ctgaattcat ggattggaag actcaaccta    960

attagtatgt tacttgtccc taagttgata taaatggacc aactccttga aaagcacaaa   1020

ctactactac aagtcatcca atatgaaata atttgaatag cttgtaacta ttaaaagtga   1080

attctacaat tcctatcaaa atttcagcaa gaattttttg tagatataaa caagactatt   1140

cttaaagtgc agtggcacga tcttaaattt caagctattc ttgaaattta aatggagagg   1200

caaaataagt agaatagcta ataataattt tgaaaaagaa gaaaatgaga agagtcagcc   1260

tgtctgattt caagatagat catactgcta tcacaatcaa gactgtggta tctgcagagg   1320

gactgacaca gagatcaggg gagcaaaatg aactagaaac agatccacac atatatgccc   1380

agctgattct tgacaaaggt tcataagcaa ttcagtggag aagggatagg atagcctttt   1440

aacaaatggt gctggagcag ttggacattt gtaggcaaaa attgaacctt gccctgaatt   1500

tcacaactta aacacaaaaa ttaactcaaa atggatcata ggcttaaata taaaatacaa   1560

cttctaggat aaaacataga aaatcttcag gatgcagggc tacgcagagt tctgagactt   1620

gatacctaaa gcataattca taaaagaaaa aactgataaa ctggacttca tcaaaattta   1680

aaactcttgc tctataaaag acaatgaaaa catatgctac agactgagag gagatatttt   1740

taaaccacat atctgacaga gggttggtat ctacagtata taaagaactc tcaaaactca   1800

acagtaaaac aaacaatccg attaagacat aagcaaaaga caggaggaga tacttcaatg   1860

aagaggatat acagatggca gtaagcacat gaaaatatgc tcagcatcat tagccatcag   1920

ggaaatgcac attaaaacca taatgagctg ccaatacaca cctaacagaa tgtttaaaaa   1980

aagtagaaca caagatgctg gagaagatgt ggaggaactg gacccctcat tcattgctgg   2040

tagggatgta aaatggtacc gccactctag aaagcagtct ggcagtttct tcaaatctcc   2100

acgtgcaact acgaacaact tggcaattgc actcctaggc atttatccca gggaaatgaa   2160

aatttatgtt cacatgaaaa cctgcctact aatattcaaa acagttgtat tcatagtagc   2220

ccaaaactgg aaacaactcc atgtcctttg gtggataaat ggttaaacaa aatgaggtcc   2280

atccatgcca cagaagacta ttcaataata caaagggctg ggcatggtgg cacctgcctg   2340

tagtcccacc tactggggag gctgaggctg gaggattgct tgagcccagg aagtccaggc   2400

tgcagtgagc catgatcatg ccactgtgct ccatcctgga tgacagtgag accctgtctt   2460

aaagcaacaa caaaggaaca aactacacag caacctggat gggcctccag agaattatgt   2520

tgagtgaaaa aagccgttcc taaaggtttc acactgtatg ttcctttctg taacatcttt   2580

gaaatgacac agttgctgag gtggagaaca gattagggtt tgctaggggt ggagagaagt   2640

aggtgtgcct ataaagggca acaggagggg tcctcacagt gatgggtgct ctggctgtgt   2700

ttacatccat gtcctggtgt gatgtgctgt agttctgcaa gatgtcactg ctgggggcaa   2760

tagggtaaag ggagcgatgg atctccctgt atcatttctt ataataagag aatttacaat   2820

taccttaaaa taaaagttta attataaag                                     2849


<210>  3719
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  3719

Met Pro Leu Arg Ile Phe Ile Arg Ile Ile Val Asn Ser Cys Phe Leu 
1               5                   10                  15


Trp Leu Ile Ser Ser Ser Pro Ser Arg Ile Ser Cys Leu Val Cys Asp 
            20                  25                  30


Leu Ala Phe Pro Val Leu Glu Val Cys Val Pro Gln Ile Cys Leu Tyr 
        35                  40                  45


Phe Phe His Ser Leu His Leu Gly Asp Arg Val Arg Leu Cys Leu Lys 
    50                  55                  60


Lys Thr Lys Gln Asn Lys Thr Asn Ser Asp Lys Gln Asp Met Phe Leu 
65                  70                  75                  80


Asn Asn Glu Tyr Val Asp Ile Lys Ile Lys Ser Ile Pro Phe Thr Ile 
                85                  90                  95


Thr 



<210>  3720
<211>  598
<212>  DNA
<213>  Homo sapiens

<400>  3720
actgtttctt ggagtccaca tctttttctc tcttggatga tcctcgtttt gctgggagta     60

gatcctctag tatgtttttc aaaagggggt ttttagagtg taaagatccc aaggcactgc    120

aggtgtgaaa ataactattt tgcaccttga ttgacagttt ggttttaaat taacttccag    180

atttaaatta atttccacac agaattttaa agggattacc atattcccat ttatcaggat    240

acatctgatg ctgatctgag tcttactgct tttacagcct ggaattgtct cgccatttaa    300

acgagtattc ctaaaaggtg aaaagagtag agataagaaa gcccatgaga aggtgacaga    360

gaggcgccct ctgcacactg tggtgttgtc attgcctgag cgcgtcgagc cagacagact    420

gctgagcgac tatattgaga aggaggtaaa gtatttaggt cagttaacgt ccataccagg    480

atacctgaat ccctccagta ggactgaaat cctgcatttc atagacaatg caaagagagc    540

ccaccagctt ccgggacact tgactcagga gcacgatgct gtgctcagcc tgtctgcg      598


<210>  3721
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  3721

Val Leu Leu Leu Leu Gln Pro Gly Ile Val Ser Pro Phe Lys Arg Val 
1               5                   10                  15


Phe Leu Lys Gly Glu Lys Ser Arg Asp Lys Lys Ala His Glu Lys Val 
            20                  25                  30


Thr Glu Arg Arg Pro Leu His Thr Val Val Leu Ser Leu Pro Glu Arg 
        35                  40                  45


Val Glu Pro Asp Arg Leu Leu Ser Asp Tyr Ile Glu Lys Glu Val Lys 
    50                  55                  60


Tyr Leu Gly Gln Leu Thr Ser Ile Pro Gly Tyr Leu Asn Pro Ser Ser 
65                  70                  75                  80


Arg Thr Glu Ile Leu His Phe Ile Asp Asn Ala Lys Arg Ala His Gln 
                85                  90                  95


Leu Pro Gly His Leu Thr Gln Glu His Asp Ala Val Leu Ser Leu Ser 
            100                 105                 110


<210>  3722
<211>  2508
<212>  DNA
<213>  Homo sapiens

<400>  3722
agattaggaa atttgccttg aagaagtgag cttggccaga ggcacgctgt ttaatttcaa     60

agtgctgctg actcaaactc atgagtcctg gaggcaggta gaggcacttg taggctgagg    120

acccgtagag cccggtgtgc cctgcccaag ccccacctgg gaatggagtt atctctgtaa    180

agatcttgct gcctttgagc aagcactgca aatggggtaa ctggaacagc cttgtcgcgt    240

gtttccaccc ttcgtatgag gcaggtacca tgggtcttca ccaacagcac ggcctgttgt    300

ctccaggaaa tggtagcccc tcacagtgct ttctgtctgc ttgtttagct ttggcatttg    360

aatgtgcaga atggtggact ttgaaattaa tgtccttctg ttgactgcag aatttctgct    420

ggaaatgcag ggaggctgct tgtggggttc gcgtgctgtg ggaagtaggg aaaatgagct    480

ggtttacttt gtgtcttttt gtgcatgcag actgtttgga ttttgccaac agtttctggg    540

tgctgcctgc tttttaaact tttaaaaaat tgtaaacagc ttcagtggct ttgcagaagg    600

aagctgtggt ttctggtctt cctgttcagt catgtttttt tcagagggag ggctaacatc    660

tggccatatt tttcaacaaa ttcagaagtg agtagagaat gcatagtagc tgtcggcaga    720

ggaggaacca gaatctctcc aaagaaattc ctcaaacaga atttcacaca gggtattcca    780

tggagaatga gcctggaatt gtctcgccat ttaaacgagt attcctaaaa ggtgaaaaga    840

gtagagataa gaaagcccat gagaaggtga cagagaggcg ccctctgcac actgtggtgt    900

tgtcattgcc tgagcgcgtc gagccagaca gactgctgag cgactatatt gagaaggagg    960

taaagtattt aggtcagtta acgtccatac caggatacct gaatccctcc agtaggactg   1020

aaatcctgca tttcatagac aatgcaaaga gagcccacca gcttccggga cacttgactc   1080

aggagcacga tgctgtgctc agcctgtctg cgtacaacgt caagctggcc tggagggacg   1140

gggaggatat catcctcagg gtgcccatcc atgacatcgc cgccgtctcc tatgttcggg   1200

atgacgctgc acacctggtg gtcctgaaga cagcccagga cccagggatc tcccccagcc   1260

agagtctgtg tgcggaaagt tccagaggcc tcagtgcagg ctccctgtcg gagagtgcag   1320

ttgggcccgt ggaggcatgc tgcctggtca tcctggctgc agagagcaag gtcgctgcgg   1380

aggagctttg ctgtctgcta ggccaggtct tccaggttgt ttacacggag tccaccatcg   1440

actttctgga cagagcgata tttgatgggg cctctacccc gacccaccac ctgtccctgc   1500

acagcgatga ctcttctaca aaagtggaca ttaaggagac ctacgaggtg gaagccagca   1560

ctttctgctt ccctgaatct gtggatgtgg gtggtgcatc accccacagc aagaccatca   1620

gtgagagcga gctgagcgcc agcgccactg agctgctgca ggactacatg ctgacgctgc   1680

gcaccaagct gtcatcacag gagatccagc agtttgcagc actgctgcac gagtaccgca   1740

atggggcctc tatccacgag ttctgcatca acctgcggca gctctacggg gacagccgca   1800

agttcctgct gcttggtctg aggcccttca tccctgagaa ggacagccag cacttcgaga   1860

acttcctgga gaccattggc gtgaaggatg gccgcggcat catcactgac agctttggca   1920

ggcaccggcg ggccctgagc accacatcca gttccaccac caatgggaac agggccacgg   1980

gcagctctga tgaccggtcg gcaccctcag agggggatga gtgggaccgc atgatctcgg   2040

acatcagcag cgacattgag gcgctgggct gcagcatgga ccaggactca gcatgatgga   2100

cagtggatgg gggggcaccc acaccttccg cgcagtcgtc ataggccttc ccagaaggag   2160

ctgcccagac ctgcgtgtca gcccttggtg gtggccaggg agaggcgccc ggtgcagatg   2220

gccccgggcg gcccaggtcc tctactgtga aggagcaggg agctgccgag ggacacgagc   2280

ctcagtgcgg ggtggaaggc tctttgcctt gtccaccagg gctcagccaa gccctgcagt   2340

gtgtccccgc tcggggaggg cccggccgag cgggcaggga gagccagtcc tgtcggctgg   2400

gcccttggac ggctgtcagt tttgcacatg atgttcctat tgtaactctc agagacctta   2460

aaaagaagtt tactgcaatg tgaataattt aatctctggt tgccaagc                2508


<210>  3723
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  3723

Met His Ser Ser Cys Arg Gln Arg Arg Asn Gln Asn Leu Ser Lys Glu 
1               5                   10                  15


Ile Pro Gln Thr Glu Phe His Thr Gly Tyr Ser Met Glu Asn Glu Pro 
            20                  25                  30


Gly Ile Val Ser Pro Phe Lys Arg Val Phe Leu Lys Gly Glu Lys Ser 
        35                  40                  45


Arg Asp Lys Lys Ala His Glu Lys Val Thr Glu Arg Arg Pro Leu His 
    50                  55                  60


Thr Val Val Leu Ser Leu Pro Glu Arg Val Glu Pro Asp Arg Leu Leu 
65                  70                  75                  80


Ser Asp Tyr Ile Glu Lys Glu Val Lys Tyr Leu Gly Gln Leu Thr Ser 
                85                  90                  95


Ile Pro Gly Tyr Leu Asn Pro Ser Ser Arg Thr Glu Ile Leu His Phe 
            100                 105                 110


Ile Asp Asn Ala Lys Arg Ala His Gln Leu Pro Gly His Leu Thr Gln 
        115                 120                 125


Glu His Asp Ala Val Leu Ser Leu Ser Ala Tyr Asn Val Lys Leu Ala 
    130                 135                 140


Trp Arg Asp Gly Glu Asp Ile Ile Leu Arg Val Pro Ile His Asp Ile 
145                 150                 155                 160


Ala Ala Val Ser Tyr Val Arg Asp Asp Ala Ala His Leu Val Val Leu 
                165                 170                 175


Lys Thr Ala Gln Asp Pro Gly Ile Ser Pro Ser Gln Ser Leu Cys Ala 
            180                 185                 190


Glu Ser Ser Arg Gly Leu Ser Ala Gly Ser Leu Ser Glu Ser Ala Val 
        195                 200                 205


Gly Pro Val Glu Ala Cys Cys Leu Val Ile Leu Ala Ala Glu Ser Lys 
    210                 215                 220


Val Ala Ala Glu Glu Leu Cys Cys Leu Leu Gly Gln Val Phe Gln Val 
225                 230                 235                 240


Val Tyr Thr Glu Ser Thr Ile Asp Phe Leu Asp Arg Ala Ile Phe Asp 
                245                 250                 255


Gly Ala Ser Thr Pro Thr His His Leu Ser Leu His Ser Asp Asp Ser 
            260                 265                 270


Ser Thr Lys Val Asp Ile Lys Glu Thr Tyr Glu Val Glu Ala Ser Thr 
        275                 280                 285


Phe Cys Phe Pro Glu Ser Val Asp Val Gly Gly Ala Ser Pro His Ser 
    290                 295                 300


Lys Thr Ile Ser Glu Ser Glu Leu Ser Ala Ser Ala Thr Glu Leu Leu 
305                 310                 315                 320


Gln Asp Tyr Met Leu Thr Leu Arg Thr Lys Leu Ser Ser Gln Glu Ile 
                325                 330                 335


Gln Gln Phe Ala Ala Leu Leu His Glu Tyr Arg Asn Gly Ala Ser Ile 
            340                 345                 350


His Glu Phe Cys Ile Asn Leu Arg Gln Leu Tyr Gly Asp Ser Arg Lys 
        355                 360                 365


Phe Leu Leu Leu Gly Leu Arg Pro Phe Ile Pro Glu Lys Asp Ser Gln 
    370                 375                 380


His Phe Glu Asn Phe Leu Glu Thr Ile Gly Val Lys Asp Gly Arg Gly 
385                 390                 395                 400


Ile Ile Thr Asp Ser Phe Gly Arg His Arg Arg Ala Leu Ser Thr Thr 
                405                 410                 415


Ser Ser Ser Thr Thr Asn Gly Asn Arg Ala Thr Gly Ser Ser Asp Asp 
            420                 425                 430


Arg Ser Ala Pro Ser Glu Gly Asp Glu Trp Asp Arg Met Ile Ser Asp 
        435                 440                 445


Ile Ser Ser Asp Ile Glu Ala Leu Gly Cys Ser Met Asp Gln Asp Ser 
    450                 455                 460


Ala 
465


<210>  3724
<211>  542
<212>  DNA
<213>  Homo sapiens

<400>  3724
aaatttgcct tgaagaagtg agcttggcca gaggcacgct gtttaatttc aaagtgctgc     60

tgactcaaac tcatgagtcc tggaggcagg tagaggcact tgtaggctga ggacccgtag    120

agcccggtgt gccctgccca agccccacct gggaatggag ttatctctgt aaagatcttg    180

ctgcctttga gcaagcactg caaatggggt aactggaaca gccttgtcgc gtgtttccac    240

ccttcgtatg agcctggaat tgtctcgcca tttaaacgag tattcctaaa aggtgaaaag    300

agtagagata agaaagccca tgagaaggtg acagagaggc gccctctgca cactgtggtg    360

ttgtcattgc ctgagcgcgt cgagccagac agactgctga gcgactatat tgagaaggag    420

gtaaagtatt taggtcagtt aacgtccata ccaggatacc tgaatccctc cagtaggact    480

gaaatcctgc atttcataga caatgcaaag agagcccacc agcttccggg acacttgact    540

ca                                                                   542


<210>  3725
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  3725

Ser Pro Val Cys Pro Ala Gln Ala Pro Pro Gly Asn Gly Val Ile Ser 
1               5                   10                  15


Val Lys Ile Leu Leu Pro Leu Ser Lys His Cys Lys Trp Gly Asn Trp 
            20                  25                  30


Asn Ser Leu Val Ala Cys Phe His Pro Ser Tyr Glu Pro Gly Ile Val 
        35                  40                  45


Ser Pro Phe Lys Arg Val Phe Leu Lys Gly Glu Lys Ser Arg Asp Lys 
    50                  55                  60


Lys Ala His Glu Lys Val Thr Glu Arg Arg Pro Leu His Thr Val Val 
65                  70                  75                  80


Leu Ser Leu Pro Glu Arg Val Glu Pro Asp Arg Leu Leu Ser Asp Tyr 
                85                  90                  95


Ile Glu Lys Glu Val Lys Tyr Leu Gly Gln Leu Thr Ser Ile Pro Gly 
            100                 105                 110


Tyr Leu Asn Pro Ser Ser Arg Thr Glu Ile Leu His Phe Ile Asp Asn 
        115                 120                 125


Ala Lys Arg Ala His Gln Leu Pro Gly His Leu 
    130                 135


<210>  3726
<211>  1134
<212>  DNA
<213>  Homo sapiens

<400>  3726
gaagaagtga gcttggccag aggcacgctg tttaatttca aagtgctgct gactcaaact     60

catgagtcct ggaggcaggt agaggcactt gtaggctgag gacccgtaga gcccggtgtg    120

ccctgcccaa gccccacctg ggaatggagt tatctctgta aagatcttgc tgcctttgag    180

caagcactgc aaatggggta actggaacag ccttgtcgcg tgtttccacc cttcgtatga    240

ggcaggtacc atgggtcttc accaacagca cggcctgttg tctccaggaa atggtagccc    300

ctcacagtgc tttctgtctg cttgtttagc tttggcattt gaatgtgcag aatggtggac    360

tttgaaatta atgtccttct gttgactgca gaatttctgc tggaaatgca gggaggctgc    420

ttgtggggtt cgcgtgctgt gggaagtagg gaaaatgagc tggtttactt tgtgtctttt    480

tgtgcatgca gactgtttgg attttgccaa cagtttctgg gtgctgcctg ctttttaaac    540

ttttaaaaaa ttgtaaacag cttcagtggc tttgcagaag gaagctgtgg tttctggtct    600

tcctgttcag tcatgttttt ttcagaggga gggctaacat ctggccatat ttttcaacaa    660

attcagaagt gagtagagaa tgcatagtag ctgtcggcag aggaggaacc agaatctctc    720

caaagaaatt cctcaaacag aatttcacac agggtattcc atggagaatg agcctggaat    780

tgtctcgcca tttaaacgag tattcctaaa aggtgaaaag agtagagata agaaagccca    840

tgagaaggtg acagagaggc gccctctgca cactgtggtg ttgtcattgc ctgagcgcgt    900

cgagccagac agactgctga gcgactatat tgagaaggag gtaaagtatt taggtcagtt    960

aacgtccata ccaggatacc tgaatccctc cagtaggact gaaatcctgc atttcataga   1020

caatgcaaag agagcccacc agcttccggg acacttgact caggagcacg atgctgtgct   1080

cagcctgtct gcgtacaacg tcaagctggc ctggagggac ggggaggata tcat         1134


<210>  3727
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  3727

Met His Ser Ser Cys Arg Gln Arg Arg Asn Gln Asn Leu Ser Lys Glu 
1               5                   10                  15


Ile Pro Gln Thr Glu Phe His Thr Gly Tyr Ser Met Glu Asn Glu Pro 
            20                  25                  30


Gly Ile Val Ser Pro Phe Lys Arg Val Phe Leu Lys Gly Glu Lys Ser 
        35                  40                  45


Arg Asp Lys Lys Ala His Glu Lys Val Thr Glu Arg Arg Pro Leu His 
    50                  55                  60


Thr Val Val Leu Ser Leu Pro Glu Arg Val Glu Pro Asp Arg Leu Leu 
65                  70                  75                  80


Ser Asp Tyr Ile Glu Lys Glu Val Lys Tyr Leu Gly Gln Leu Thr Ser 
                85                  90                  95


Ile Pro Gly Tyr Leu Asn Pro Ser Ser Arg Thr Glu Ile Leu His Phe 
            100                 105                 110


Ile Asp Asn Ala Lys Arg Ala His Gln Leu Pro Gly His Leu Thr Gln 
        115                 120                 125


Glu His Asp Ala Val Leu Ser Leu Ser Ala Tyr Asn Val Lys Leu Ala 
    130                 135                 140


Trp Arg Asp Gly Glu Asp 
145                 150


<210>  3728
<211>  1488
<212>  DNA
<213>  Homo sapiens

<400>  3728
gaagaagtga gcttggccag aggcacgctg tttaatttca aagtgctgct gactcaaact     60

catgagtcct ggaggcaggt agaggcactt gtaggctgag gacccgtaga gcccggtgtg    120

ccctgcccaa gccccacctg ggaatggagt tatctctgta aagatcttgc tgcctttgag    180

caagcactgc aaatggggta actggaacag ccttgtcgcg tgtttccacc cttcgtatga    240

ggcaggtacc atgggtcttc accaacagca cggcctgttg tctccaggaa atggtagccc    300

ctcacagtgc tttctgtctg cttgtttagc tttggcattt gaatgtgcag aatggtggac    360

tttgaaatta atgtccttct gttgactgca gaatttctgc tggaaatgca gggaggctgc    420

ttgtggggtt cgcgtgctgt gggaagtagg gaaaatgagc tggtttactt tgtgtctttt    480

tgtgcatgca gactgtttgg attttgccaa cagtttctgg gtgctgcctg ctttttaaac    540

ttttaaaaaa ttgtaaacag cttcagtggc tttgcagaag gaagctgtgg tttctggtct    600

tcctgttcag tcatgttttt ttcagaggga gggctaacat ctggccatat ttttcaacaa    660

attcagaagt gagtagagaa tgcatagtag ctgtcggcag aggaggaacc agaatctctc    720

caaagaaatt cctcaaacag aatttcacac agggtattcc atggagaatg agcctggaat    780

tgtctcgcca tttaaacgag tattcctaaa aggtgaaaag agtagagata agaaagccca    840

tgagaaggtg acagagaggc gccctctgca cactgtggtg ttgtcattgc ctgagcgcgt    900

cgagccagac agactgctga gcgactatat tgagaaggag gtaaagtatt taggtcagtt    960

aacgtccata ccaggatacc tgaatccctc cagtaggact gaaatcctgc atttcataga   1020

caatgcaaag agagcccacc agcttccggg acacttgact caggagcacg atgctgtgct   1080

cagcctgtct gcgtacaacg tcaagctggc ctggagggac ggggaggata tcatcctcag   1140

ggtgcccatc catgacatcg ccgccgtctc ctatgttcgg gatgacgctg cacacctggt   1200

ggtcctgaag acagcccagg acccagggat ctcccccagc cagagtctgt gtgcggaaag   1260

ttccagaggc ctcagtgcag gctccctgtc ggagagtgca gttgggcccg tggaggcatg   1320

ctgcctggtc atcctggctg cagagagcaa ggtcgctgcg gaggagcttt gctgtctgct   1380

aggccaggtc ttccaggttg tttacacgga gtccaccatc gactttctgg acagagcgat   1440

atttgatggg gcctctaccc cgacccacca cctgtccctg cacagcgg                1488


<210>  3729
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  3729

Met His Ser Ser Cys Arg Gln Arg Arg Asn Gln Asn Leu Ser Lys Glu 
1               5                   10                  15


Ile Pro Gln Thr Glu Phe His Thr Gly Tyr Ser Met Glu Asn Glu Pro 
            20                  25                  30


Gly Ile Val Ser Pro Phe Lys Arg Val Phe Leu Lys Gly Glu Lys Ser 
        35                  40                  45


Arg Asp Lys Lys Ala His Glu Lys Val Thr Glu Arg Arg Pro Leu His 
    50                  55                  60


Thr Val Val Leu Ser Leu Pro Glu Arg Val Glu Pro Asp Arg Leu Leu 
65                  70                  75                  80


Ser Asp Tyr Ile Glu Lys Glu Val Lys Tyr Leu Gly Gln Leu Thr Ser 
                85                  90                  95


Ile Pro Gly Tyr Leu Asn Pro Ser Ser Arg Thr Glu Ile Leu His Phe 
            100                 105                 110


Ile Asp Asn Ala Lys Arg Ala His Gln Leu Pro Gly His Leu Thr Gln 
        115                 120                 125


Glu His Asp Ala Val Leu Ser Leu Ser Ala Tyr Asn Val Lys Leu Ala 
    130                 135                 140


Trp Arg Asp Gly Glu Asp Ile Ile Leu Arg Val Pro Ile His Asp Ile 
145                 150                 155                 160


Ala Ala Val Ser Tyr Val Arg Asp Asp Ala Ala His Leu Val Val Leu 
                165                 170                 175


Lys Thr Ala Gln Asp Pro Gly Ile Ser Pro Ser Gln Ser Leu Cys Ala 
            180                 185                 190


Glu Ser Ser Arg Gly Leu Ser Ala Gly Ser Leu Ser Glu Ser Ala Val 
        195                 200                 205


Gly Pro Val Glu Ala Cys Cys Leu Val Ile Leu Ala Ala Glu Ser Lys 
    210                 215                 220


Val Ala Ala Glu Glu Leu Cys Cys Leu Leu Gly Gln Val Phe Gln Val 
225                 230                 235                 240


Val Tyr Thr Glu Ser Thr Ile Asp Phe Leu Asp Arg Ala Ile Phe Asp 
                245                 250                 255


Gly Ala Ser Thr Pro Thr His His Leu Ser Leu His 
            260                 265


<210>  3730
<211>  1595
<212>  DNA
<213>  Homo sapiens

<400>  3730
gaagaagtga gcttggccag aggcacgctg tttaatttca aagtgctgct gactcaaact     60

catgagtcct ggaggcaggt agaggcactt gtaggctgag gacccgtaga gcccggtgtg    120

ccctgcccaa gccccacctg ggaatggagt tatctctgta aagatcttgc tgcctttgag    180

caagcactgc aaatggggta actggaacag ccttgtcgcg tgtttccacc cttcgtatga    240

ggcaggtacc atgggtcttc accaacagca cggcctgttg tctccaggaa atggtagccc    300

ctcacagtgc tttctgtctg cttgtttagc tttggcattt gaatgtgcag aatggtggac    360

tttgaaatta atgtccttct gttgactgca gaatttctgc tggaaatgca gggaggctgc    420

ttgtggggtt cgcgtgctgt gggaagtagg gaaaatgagc tggtttactt tgtgtctttt    480

tgtgcatgca gactgtttgg attttgccaa cagtttctgg gtgctgcctg ctttttaaac    540

ttttaaaaaa ttgtaaacag cttcagtggc tttgcagaag gaagctgtgg tttctggtct    600

tcctgttcag tcatgttttt ttcagaggga gggctaacat ctggccatat ttttcaacaa    660

attcagaagt gagtagagaa tgcatagtag ctgtcggcag aggaggaacc agaatctctc    720

caaagaaatt cctcaaacag aatttcacac agggtattcc atggagaatg agcctggaat    780

tgtctcgcca tttaaacgag tattcctaaa aggtgaaaag agtagagata agaaagccca    840

tgagaaggtg acagagaggc gccctctgca cactgtggtg ttgtcattgc ctgagcgcgt    900

cgagccagac agactgctga gcgactatat tgagaaggag gtaaagtatt taggtcagtt    960

aacgtccata ccaggatacc tgaatccctc cagtaggact gaaatcctgc atttcataga   1020

caatgcaaag agagcccacc agcttccggg acacttgact caggagcacg atgctgtgct   1080

cagcctgtct gcgtacaacg tcaagctggc ctggagggac ggggaggata tcatcctcag   1140

ggtgcccatc catgacatcg ccgccgtctc ctatgttcgg gatgacgctg cacacctggt   1200

ggtcctgaag acagcccagg acccagggat ctcccccagc cagagtctgt gtgcggaaag   1260

ttccagaggc ctcagtgcag gctccctgtc ggagagtgca gttgggcccg tggaggcatg   1320

ctgcctggtc atcctggctg cagagagcaa ggtcgctgcg gaggagcttt gctgtctgct   1380

aggccaggtc ttccaggttg tttacacgga gtccaccatc gactttctgg acagagcgat   1440

atttgatggg gcctctaccc cgacccacca cctgtccctg cacagcggac catggccaga   1500

cccatgggaa gctgctcagg ctgccctggg aggccagctg gcagtggtgg agcagtggca   1560

gatggggaag aatggaaggt accccagagc tgtct                              1595


<210>  3731
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  3731

Met His Ser Ser Cys Arg Gln Arg Arg Asn Gln Asn Leu Ser Lys Glu 
1               5                   10                  15


Ile Pro Gln Thr Glu Phe His Thr Gly Tyr Ser Met Glu Asn Glu Pro 
            20                  25                  30


Gly Ile Val Ser Pro Phe Lys Arg Val Phe Leu Lys Gly Glu Lys Ser 
        35                  40                  45


Arg Asp Lys Lys Ala His Glu Lys Val Thr Glu Arg Arg Pro Leu His 
    50                  55                  60


Thr Val Val Leu Ser Leu Pro Glu Arg Val Glu Pro Asp Arg Leu Leu 
65                  70                  75                  80


Ser Asp Tyr Ile Glu Lys Glu Val Lys Tyr Leu Gly Gln Leu Thr Ser 
                85                  90                  95


Ile Pro Gly Tyr Leu Asn Pro Ser Ser Arg Thr Glu Ile Leu His Phe 
            100                 105                 110


Ile Asp Asn Ala Lys Arg Ala His Gln Leu Pro Gly His Leu Thr Gln 
        115                 120                 125


Glu His Asp Ala Val Leu Ser Leu Ser Ala Tyr Asn Val Lys Leu Ala 
    130                 135                 140


Trp Arg Asp Gly Glu Asp Ile Ile Leu Arg Val Pro Ile His Asp Ile 
145                 150                 155                 160


Ala Ala Val Ser Tyr Val Arg Asp Asp Ala Ala His Leu Val Val Leu 
                165                 170                 175


Lys Thr Ala Gln Asp Pro Gly Ile Ser Pro Ser Gln Ser Leu Cys Ala 
            180                 185                 190


Glu Ser Ser Arg Gly Leu Ser Ala Gly Ser Leu Ser Glu Ser Ala Val 
        195                 200                 205


Gly Pro Val Glu Ala Cys Cys Leu Val Ile Leu Ala Ala Glu Ser Lys 
    210                 215                 220


Val Ala Ala Glu Glu Leu Cys Cys Leu Leu Gly Gln Val Phe Gln Val 
225                 230                 235                 240


Val Tyr Thr Glu Ser Thr Ile Asp Phe Leu Asp Arg Ala Ile Phe Asp 
                245                 250                 255


Gly Ala Ser Thr Pro Thr His His Leu Ser Leu His Ser Gly Pro Trp 
            260                 265                 270


Pro Asp Pro Trp Glu Ala Ala Gln Ala Ala Leu Gly Gly Gln Leu Ala 
        275                 280                 285


Val Val Glu Gln Trp Gln Met Gly Lys Asn Gly Arg Tyr Pro Arg Ala 
    290                 295                 300


<210>  3732
<211>  850
<212>  DNA
<213>  Homo sapiens

<400>  3732
gtagctgtcg gcagaggagg aaccagaatc tctccaaaga aattcctcaa acagaatttc     60

acacagggta ttccatggag aatgagtatt taggtcagtt aacgtccata ccaggatacc    120

tgaatccctc cagtaggact gaaatcctgc atttcataga caatgcaaag agagcccacc    180

agcttccggg acacttgact caggagcacg atgctgtgct cagcctgtct gcgtacaacg    240

tcaagctggc ctggagggac ggggaggata tcatcctcag ggtgcccatc catgacatcg    300

ccgccgtctc ctatgttcgg gatgacgctg cacacctggt ggtcctgaag acagcccagg    360

acccagggat ctcccccagc cagagtctgt gtgcggaaag ttccagaggc ctcagtgcag    420

gctccctgtc ggagagtgca gttgggcccg tggaggcatg ctgcctggtc atcctggctg    480

cagagagcaa ggtcgctgcg gaggagcttt gctgtctgct aggccaggtc ttccaggttg    540

tttacacgga gtccaccatc gactttctgg acagagcgat atttgatggg gcctctaccc    600

cgacccacca cctgtccctg cacagcgatg actcttctac aaaagtggac attaaggaga    660

cctacgaggt ggaagccagc actttagccc aactcagagc catgcccccg gggagcccca    720

ggaccaggcc aagctgacca ccctgcatgc ccagtcagct ctcctctcat catcatcatc    780

atcacttaca ttcctctgtt caaggacagg gacccacaca cacggcatgg actaggtttc    840

ctgaaacgtg                                                           850


<210>  3733
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  3733

Met Glu Asn Glu Tyr Leu Gly Gln Leu Thr Ser Ile Pro Gly Tyr Leu 
1               5                   10                  15


Asn Pro Ser Ser Arg Thr Glu Ile Leu His Phe Ile Asp Asn Ala Lys 
            20                  25                  30


Arg Ala His Gln Leu Pro Gly His Leu Thr Gln Glu His Asp Ala Val 
        35                  40                  45


Leu Ser Leu Ser Ala Tyr Asn Val Lys Leu Ala Trp Arg Asp Gly Glu 
    50                  55                  60


Asp Ile Ile Leu Arg Val Pro Ile His Asp Ile Ala Ala Val Ser Tyr 
65                  70                  75                  80


Val Arg Asp Asp Ala Ala His Leu Val Val Leu Lys Thr Ala Gln Asp 
                85                  90                  95


Pro Gly Ile Ser Pro Ser Gln Ser Leu Cys Ala Glu Ser Ser Arg Gly 
            100                 105                 110


Leu Ser Ala Gly Ser Leu Ser Glu Ser Ala Val Gly Pro Val Glu Ala 
        115                 120                 125


Cys Cys Leu Val Ile Leu Ala Ala Glu Ser Lys Val Ala Ala Glu Glu 
    130                 135                 140


Leu Cys Cys Leu Leu Gly Gln Val Phe Gln Val Val Tyr Thr Glu Ser 
145                 150                 155                 160


Thr Ile Asp Phe Leu Asp Arg Ala Ile Phe Asp Gly Ala Ser Thr Pro 
                165                 170                 175


Thr His His Leu Ser Leu His Ser Asp Asp Ser Ser Thr Lys Val Asp 
            180                 185                 190


Ile Lys Glu Thr Tyr Glu Val Glu Ala Ser Thr Leu Ala Gln Leu Arg 
        195                 200                 205


Ala Met Pro Pro Gly Ser Pro Arg Thr Arg Pro Ser 
    210                 215                 220


<210>  3734
<211>  2459
<212>  DNA
<213>  Homo sapiens

<400>  3734
cttggttcac tgcaatctcc gccccccgag tagctgggat tacaggcatg agccaccacg     60

cccagctaat ttttttgtat ttttagtaga gatggggttt caccatgttg gccaggctgg    120

tcttgaactc ctgacctcag gtgatccacc cgccttggcc tcccaatgtg ctgggattac    180

agccatgagc cactgcgcct ggccaattat tttcaataat atattttatt tacccctccg    240

tacccaaaac attattacat cagtatataa tcaatataaa aatcgttgag ctacatagca    300

ttctttcttt gcctacctct gaaaccctgt gtatagtttg cactcacaca tttcaatgtg    360

ggctcatcac attttgcata ctcagtagtc ctgtggccag tggctgccat agggacagag    420

cagccccagg agtctcactg tggggtttga ggtacagttt cttatggagc ccttgtctct    480

gtgcatgcgc taactttgca tgtggcctgg gacggccttc ttctccctcc tgaggctggc    540

ctgccctctg acaccctggc actagtggca cttctaggtt ttgttttcag tcttgaagtc    600

ctcccagggt ggtccgaact gatggtgaga gccctgcttc ctggggattg gcctcacttc    660

tgccatcagg aaaaccactg agttactcca tgtatttcag gagaacctca tttgtctagg    720

gaggcaatgg gtaggatgtt agaaacaagg gcactggggt ctgaccgtct agattgccat    780

gtggacagtg caactcacac gccctcaggc caggcctttc actttcccat gcctcagttt    840

acccatctgt aagaagggaa ctccccagaa cacatggaaa cctcctggag gtgactgttc    900

tcagggttgt atatgtggtc tgttgtatat gaacttgaag cgtgtgaaac tgcaggatga    960

catgcagctc tggtgccctt ggagctcagg ggtcgcgtgt tcccaccctt atttagagaa   1020

gcgaagtgtg tctggtgcag gcccttcacc tgagtcgttc tgtgggtgcc tgagccaggt   1080

aaaggtcctc tcagcctgtt tccatggcgg cctcagctgt ttcctcaagt gcccccatgc   1140

ctgcccttcc actgtgctaa actgagatgg tgttgacttc tcagcccagg acccagggat   1200

ctcccccagc cagagtctgt gtgcggaaag ttccagaggc ctcagtgcag gctccctgtc   1260

ggagagtgca gttgggcccg tggaggcatg ctgcctggtc atcctggctg cagagagcaa   1320

ggtcgctgcg gaggagcttt gctgtctgct aggccaggtc ttccaggttg tttacacgga   1380

gtccaccatc gactttctgg acagagcgat atttgatggg gcctctaccc cgacccacca   1440

cctgtccctg cacagcgatg actcttctac aaaagtggac attaaggaga cctacgaggt   1500

ggaagccagc actttctgct tccctgaatc tgtggatgtg ggtggtgcat caccccacag   1560

caagaccatc agtgagagcg agctgagcgc cagcgccact gagctgctgc aggactacat   1620

gctgacgctg cgcaccaagc tgtcatcaca ggagatccag cagtttgcag cactgctgca   1680

cgagtaccgc aatggggcct ctatccacga gttctgcatc aacctgcggc agctctacgg   1740

ggacagccgc aagttcctgc tgcttggtct gaggcccttc atccctgaga aggacagcca   1800

gcacttcgag aacttcctgg agaccattgg cgtgaaggat ggccgcggca tcatcactga   1860

cagctttggc aggcaccggc gggccctgag caccacatcc agttccacca ccaatgggaa   1920

cagggccacg ggcagctctg atgaccggtc ggcaccctca gagggggatg agtgggaccg   1980

catgatctcg gacatcagca gcgacattga ggcgctgggc tgcagcatgg accaggactc   2040

agcatgatgg acagtggatg ggggggcacc cacaccttcc gcgcagtcgt cataggcctt   2100

cccagaagga gctgcccaga cctgcgtgtc agcccttggt ggtggccagg gagaggcgcc   2160

cggtgcagat ggccccgggc ggcccaggtc ctctactgtg aaggagcagg gagctgccga   2220

gggacacgag cctcagtgcg gggtggaagg ctctttgcct tgtccaccag ggctcagcca   2280

agccctgcag tgtgtccccg ctcggggagg gcccggccga gcgggcaggg agagccagtc   2340

ctgtcggctg ggcccttgga cggctgtcag ttttgcacat gatgttccta ttgtaactct   2400

cagagacctt aaaaagaagt ttactgcaat gtgaataatt taatctctgg ttgccaagc    2459


<210>  3735
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  3735

Met Leu Thr Leu Arg Thr Lys Leu Ser Ser Gln Glu Ile Gln Gln Phe 
1               5                   10                  15


Ala Ala Leu Leu His Glu Tyr Arg Asn Gly Ala Ser Ile His Glu Phe 
            20                  25                  30


Cys Ile Asn Leu Arg Gln Leu Tyr Gly Asp Ser Arg Lys Phe Leu Leu 
        35                  40                  45


Leu Gly Leu Arg Pro Phe Ile Pro Glu Lys Asp Ser Gln His Phe Glu 
    50                  55                  60


Asn Phe Leu Glu Thr Ile Gly Val Lys Asp Gly Arg Gly Ile Ile Thr 
65                  70                  75                  80


Asp Ser Phe Gly Arg His Arg Arg Ala Leu Ser Thr Thr Ser Ser Ser 
                85                  90                  95


Thr Thr Asn Gly Asn Arg Ala Thr Gly Ser Ser Asp Asp Arg Ser Ala 
            100                 105                 110


Pro Ser Glu Gly Asp Glu Trp Asp Arg Met Ile Ser Asp Ile Ser Ser 
        115                 120                 125


Asp Ile Glu Ala Leu Gly Cys Ser Met Asp Gln Asp Ser Ala 
    130                 135                 140


<210>  3736
<211>  1089
<212>  DNA
<213>  Homo sapiens

<400>  3736
tttacacgga gtccaccatc gactttctgg acagagcgat atttgatggg gcctctaccc     60

cgacccacca cctgtccctg cacagcgatg actcttctac aaaagtggac attaaggaga    120

cctacgaggt ggaagccagc actttctgct tccctgaatc tgtggatgtg ggtggtgcat    180

caccccacag caagaccatc agtgagagcg agctgagcgc cagcgccact gagctgctgc    240

aggactacat gctgacgctg cgcaccaagc tgtcatcaca ggagatccag cagtttgcag    300

cactgctgca cgagtaccgc aatggggcct ctatccacga gttctgcatc aacctgcggc    360

agctctacgg ggacagccgc aagttcctgc tgcttggtct gaggcccttc atccctgaga    420

aggacagcca gcacttcgag aacttcctgg agaccattgg cgtgaaggat ggccgcggca    480

tcatcactga cagctttggc aggcaccggc gggccctgag caccacatcc agttccacca    540

ccaatgggaa cagggccacg ggcagctctg atgaccggtc ggcaccctca gagggggatg    600

agtgggaccg catgatctcg gacatcagca gcgacattga ggcgctgggc tgcagcatgg    660

accaggactc agcatgatgg acagtggatg ggggggcacc cacaccttcc gcgcagtcgt    720

cataggcctt cccagaagga gctgcccaga cctgcgtgtc agcccttggt ggtggccagg    780

gagaggcgcc cggtgcagat ggccccgggc ggcccaggtc ctctactgtg aaggagcagg    840

gagctgccga gggacacgag cctcagtgcg gggtggaagg ctctttgcct tgtccaccag    900

ggctcagcca agccctgcag tgtgtccccg ctcggggagg gcccggccga gcgggcaggg    960

agagccagtc ctgtcggctg ggcccttgga cggctgtcag ttttgcacat gatgttccta   1020

ttgtaactct cagagacctt aaaaagaagt ttactgcaat gtgaataatt taatctctgg   1080

ttgccaagc                                                           1089


<210>  3737
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  3737

Met Leu Thr Leu Arg Thr Lys Leu Ser Ser Gln Glu Ile Gln Gln Phe 
1               5                   10                  15


Ala Ala Leu Leu His Glu Tyr Arg Asn Gly Ala Ser Ile His Glu Phe 
            20                  25                  30


Cys Ile Asn Leu Arg Gln Leu Tyr Gly Asp Ser Arg Lys Phe Leu Leu 
        35                  40                  45


Leu Gly Leu Arg Pro Phe Ile Pro Glu Lys Asp Ser Gln His Phe Glu 
    50                  55                  60


Asn Phe Leu Glu Thr Ile Gly Val Lys Asp Gly Arg Gly Ile Ile Thr 
65                  70                  75                  80


Asp Ser Phe Gly Arg His Arg Arg Ala Leu Ser Thr Thr Ser Ser Ser 
                85                  90                  95


Thr Thr Asn Gly Asn Arg Ala Thr Gly Ser Ser Asp Asp Arg Ser Ala 
            100                 105                 110


Pro Ser Glu Gly Asp Glu Trp Asp Arg Met Ile Ser Asp Ile Ser Ser 
        115                 120                 125


Asp Ile Glu Ala Leu Gly Cys Ser Met Asp Gln Asp Ser Ala 
    130                 135                 140


<210>  3738
<211>  1173
<212>  DNA
<213>  Homo sapiens

<400>  3738
gtgagggctg ctcctcagtg cctccttctt ccctttcttg ctgctggtgc cagagccctt     60

tgtgggcact acacgccttg tgttggccca gcagctgcag agagacagct gctgagctct    120

caggcatcct ctctatctca tttagtcctc ggtggcccag cgagataggt gcaatcttca    180

tccccatttt agagatgggg aagtggaggc ttagaagtca acagcttatc cagaggaatg    240

taccatatga gtagcagatg atttatcgag ctgtaattaa acattcagtt ttagtgcgac    300

tggtttggcc cttgtgcttt aaaattccca aagggccttt ttttctttaa taattttttt    360

tttactgaga agtacacaag tcatacatgt acagttgaat gaattttcat aaagtaaaca    420

catcatgtaa caccactact gggggttgct gaagtgggct tcttcccctg ccagcctttc    480

ccaagacctc cccgtgggat ccacacacag atgtgcacac gttacgcaca tgcatgcatt    540

ctctgcttat ttctgccttg gagttttgct tgctgtgttc tctctactac agctatgcca    600

aaacatagca gcataaacag cagaaatata ttctcttata attctatacg ttaagagtcc    660

attgtgggtc ccactgggct aaagttgagg tgtccacagg gctggttcct tctggaggct    720

ccagagaaga agccatttcc ttgtctttcc agctcctaaa ggcggctgca tgccttggct    780

catggccctt cctctgtctt cacagccagc cacgtgacct cttccacagt cacatcttcc    840

tttgactgtc agcttcctct gcatttcagg actcttgcaa tcacattgag cccacccaaa    900

ttctccaggg tcatctccct atttcaaggt cagctgataa gcatccttta ctcccctttg    960

aaattggtaa catattcacc aattccaggg attaggatgt ggacgtcttt ggggggtcat   1020

tattctgccc tccatactta ccttgttcct agtgccagaa atgtcccttt tatctctcag   1080

cctctccctc tgcttcattt aaaatcttac cctctctgca acactcacct gcctcgctca   1140

caaagctttc actcactgtc tgtgctgggg tga                                1173


<210>  3739
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  3739

Met Trp Thr Ser Leu Gly Gly His Tyr Ser Ala Leu His Thr Tyr Leu 
1               5                   10                  15


Val Pro Ser Ala Arg Asn Val Pro Phe Ile Ser Gln Pro Leu Pro Leu 
            20                  25                  30


Leu His Leu Lys Ser Tyr Pro Leu Cys Asn Thr His Leu Pro Arg Ser 
        35                  40                  45


Gln Ser Phe His Ser Leu Ser Val Leu Gly 
    50                  55


<210>  3740
<211>  465
<212>  DNA
<213>  Homo sapiens

<400>  3740
ggtctgaggc ccttcatccc tgagaaggac agccagcact tcgagaactt cctggagacc     60

attggcgtga aggatggccg cggcatcatc actgacagct ttggcaggca ccggcggctg    120

cccagacctg cgtgtcagcc cttggtggtg gccagggaga ggcgcccggt gcagatggcc    180

ccgggcggcc caggtcctct actgtgaagg agcagggagc tgccgaggga cacgagcctc    240

agtgcggggt ggaaggctct ttgccttgtc caccagggct cagccaagcc ctgcagtgtg    300

tccccgctcg gggagggccc ggccgagcgg gcagggagag ccagtcctgt cggctgggcc    360

cttggacggc tgtcagtttt gcacatgatg ttcctattgt aactctcaga gaccttaaaa    420

agaagtttac tgcaatgtga ataatttaat ctctggttgc caagc                    465


<210>  3741
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  3741

Met Ala Ala Ala Ser Ser Leu Thr Ala Leu Ala Gly Thr Gly Gly Cys 
1               5                   10                  15


Pro Asp Leu Arg Val Ser Pro Trp Trp Trp Pro Gly Arg Gly Ala Arg 
            20                  25                  30


Cys Arg Trp Pro Arg Ala Ala Gln Val Leu Tyr Cys Glu Gly Ala Gly 
        35                  40                  45


Ser Cys Arg Gly Thr Arg Ala Ser Val Arg Gly Gly Arg Leu Phe Ala 
    50                  55                  60


Leu Ser Thr Arg Ala Gln Pro Ser Pro Ala Val Cys Pro Arg Ser Gly 
65                  70                  75                  80


Arg Ala Arg Pro Ser Gly Gln Gly Glu Pro Val Leu Ser Ala Gly Pro 
                85                  90                  95


Leu Asp Gly Cys Gln Phe Cys Thr 
            100


<210>  3742
<211>  796
<212>  DNA
<213>  Homo sapiens

<400>  3742
atactctccg gtgtcccttc actgccctct ggcgtcccct caccctctgg tgtcctgtca     60

ccaccctctg atgtcccttc attactctct ggtgtcccct cattaccctc tggtgtccct    120

tcatctgctc catgtcctct actctttctg ctagcaaaga ccagcgactg cagcacgggg    180

gccacacctg ggatggaccc tggaggggca agcatgtggt tcctttgaca ctccacacag    240

aaggcccatg caaggccatg ttcaaccaga gggatggaag ggggacactg aaccttctgg    300

cacagggtgg gctctggtag ggggcaagag cccaggagac tgtgtggttt gtcctcagcc    360

tctcctgatg cttccagggc atgtccattt tcatgtaaac ttaagagaca gtgtcaacag    420

taaagagcct gctgcctgcc ctggcctggg gtcccatgag taagcagctc tacaacagcc    480

cagtacagtg gaaaaactcg cccataaaac actgaccggg ccggccgcgg tggctcacgc    540

ctgtaatccc aacactttgg gaggcaggcg gatcacaaag tcaggagttt gagaccagcc    600

tggccaatat ggtgaaaccc cgtctctgct aaaaatacaa aaattagctg ggcgtggtgg    660

caggcgcctg tagtcccagc tactcgggag gctgagacag gagaatcgct tgaacccagg    720

aggtgtaggt tgcagtgagc caaaaccgca ccactgcact ccaacctggg caacagagtg    780

agactctgtc ttgaga                                                    796


<210>  3743
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  3743

Met Gln Gly His Val Gln Pro Glu Gly Trp Lys Gly Asp Thr Glu Pro 
1               5                   10                  15


Ser Gly Thr Gly Trp Ala Leu Val Gly Gly Lys Ser Pro Gly Asp Cys 
            20                  25                  30


Val Val Cys Pro Gln Pro Leu Leu Met Leu Pro Gly His Val His Phe 
        35                  40                  45


His Val Asn Leu Arg Asp Ser Val Asn Ser Lys Glu Pro Ala Ala Cys 
    50                  55                  60


Pro Gly Leu Gly Ser His Glu 
65                  70


<210>  3744
<211>  7237
<212>  DNA
<213>  Homo sapiens

<400>  3744
ggggaccggc gggagccctg tgctctgacc ccagggccca gccacctggc cctcacgttc     60

ctgcccagca agccgggtgc ccggccccag cccgagggag ccagctggga tgcagggcct    120

ggtggggcac cctcggcctg ggcggaccca ggggagggcg gcccaagccc catgctcctc    180

cctgagggcc tgtcttccca ggctctgtcc acggaggctc ctctcccggc caccctggag    240

ccccggattg tgatgggaga ggagacgtgc caggccctcc tgtcacccag agctgcccgg    300

acagcgctca gggaccagga gggtgggcac gcaagcccag acccaccccc cgagctgtgt    360

tctcagggtg atctttctgt gccttcccct cccccagacc ctgattcctt cttcacgcct    420

ccctccaccc ccaccaagac cacctatgcc ctgcttcctg cctgtgggcc ccacggggac    480

gccagggact cagaggctga gctgcgggat gagctgctgg actcgccccc cgcctcaccc    540

tcgggctcct acattacggc cgatggggac agctgggcct cttcaccctc ctgttccctc    600

agcctgctgg ctccggctga agggctggac ttcccctcag gctggggcct gtccccgcag    660

gggtccatgg tggatgaacg agagctgcac ccagcaggga ccccagagcc cccgtcctct    720

gagtccagcc tctctgcaga cagcagctcc tcctggggcc aggagggcca cttcttcgac    780

ctggacttcc tggccaatga cccaatgatc cccgcagccc tcctaccctt ccagggcagc    840

ctcatctttc aggtggaggc agtggaggtg acaccgctat ccccagagga agaagaagag    900

gaggctgtgg cggatcccga cccaggtggg gacctggctg gggagggtga ggaggacagc    960

acgtctgcct ccttcctgca gtcactgtct gacctgtcca tcacggaggg catggacgag   1020

gcttttgcct tccgggacga cacctctgca gcctcctctg attcagactc agcctcctac   1080

gcagaggcag atgatgagag gctgtacagc ggggagcccc atgcccaggc cactttgctc   1140

caggacagtg tccagaagac agaggaggag agcggaggtg gggccaaggg gctgcaggct   1200

caggatggga ctgtgtcctg ggccgtggag gctgctcctc agacctcaga cagaggggcc   1260

tatctgtccc agagacagga attgatctca gaagtaacag aagagggcct tgctttaggc   1320

caggagtcca ctgccactgt gacccctcac actctgcagg tagccccagg cctccaggtg   1380

gaggtggcta ccagagtgac cccacaggct ggggaggaag aaacagactc caccgctgga   1440

caagaatctg ctgccatggc aatgcctcag ccctcccagg agggcatcag cgagatctta   1500

ggccaagagt ctgtcactgc agaaaaactt ccaactccac aggaagaaac aagcctcaca   1560

ttgtgtccag actctcctca gaacttgaag gaagaaggag ggctggacct cccctctggc   1620

agaaagcctg tagctgcagc cacgattgtc cccaggcagg ctaaagagga cctcacctta   1680

ccccaggact ccgctatgac accgcctctg cccctacaag acacagatct ctcatcagcc   1740

ccaaagcctg tggctgcagc cacgattgtg tcccagcagg ctgaagaggg cctcacctta   1800

ccccaggact ccgttatgac accgcctctg cccctacaag acacagaact ctcgtcagcc   1860

ccaaagcctg tggctgcagc cacgcttgtg tcccagcagg ctgaagaggg cctcacctta   1920

ccccaggact ccgctatgac accgcctctg cccctacaag acacagatct ctcgtcagcc   1980

ccaaagcctg tggctgcagc cacgcttgtg tcccagcagg ctgaagaggg cctcacctta   2040

ccccaggact ccgctatgac accgcctctg cccctacaag acacagatct ctcgtcagcc   2100

ccaaagcctg tggctgcagc cacgcttgtg tcccagcagg ctgaagaggg cctcacctta   2160

ccccaggact ccgctatgac accgcctctg cccctacaag acacagatct ctcgtcagcc   2220

ccaaagcctg tggctgcagc cacgattgtg tcccagcagg ctgaagaggg cctcacctta   2280

ccccaggact ccgctatgac accgcctctg cccctacaag acacagatct ctcgtcagcc   2340

ccaaagcctg tggctgcagc cacgattgtg tcccagcagg ctgaagaggg cctcacctta   2400

ccccaggact ccgctatgac accgcctctg cccctacaag acacagatct ctcgtcagcc   2460

ccaaagcctg tggctgcagc cacgcctgtg tcccagcagg ctgaagaggg cctcacctta   2520

ccccaggact ccgctatgac accgcctctg cccctacaag acacagatag gccccacctc   2580

aggtccagag cctctggctg tggccacccc tcaaaccttg caggcagaag caggctgtgc   2640

cccagggaca gagcctgtgg ccaccatggc tcagcaggaa gtaggtgagg ccttaggccc   2700

caggccagca cctgaggaga agaatgcagc cctccctaca gtcccggagc ctgcagcctt   2760

ggaccaggtc caacaggatg acccacagcc agctgcagaa gctgggacac cttgggccgc   2820

acaggaagat gcggattcca ctttgggcat ggaggccctc agtctccctg agccggcctc   2880

tggtgctggg gaggaaatag cagaagccct ttctaggcct ggacgggaag catgtctgga   2940

agcgcgagcg cacacaggtg atggggctaa gcctgactca ccccaaaagg agaccctgga   3000

ggttgagaac cagcaggaag gaggcctgaa gccactggca caggaacatg gacccaggtc   3060

agcacttgga ggtgcaaggg aggtccccga tgcgcctcct gctgcctgcc ctgaggtcag   3120

ccaggcccgg ctcctgagcc cagccaggga ggaaagaggc ctgagtggca agtccacccc   3180

ggagcccacg cttccctcag ctgtggccac agaggccagt ctggactcct gcccagagtc   3240

ttcagtaggg gctgtgtcca gtctggacag aggctgccct gacgcgcctg cccccacgtc   3300

tgcaccaacc tcccagcagc cggagcctgt actgggtctg ggcagtgttg agcaacccca   3360

cgaagtaccc agtgtccttg gcaccccctt gctgcagccc ccagaaaacc ttgccaaggg   3420

tcagcccagc acgcccgtgg acaggcccct gggccctgac ccttctgctc ctggtaccct   3480

tgctggggca gccctacccc cactggagcc cccagccccc tgcctgtgcc aggaccccca   3540

ggaagactct gtggaagacg aggagccccc aggctctctg ggcctcccac cgccccaggc   3600

aggagtccag cctgccgctg ctgctgtctc aggaaccaca cagcctctgg ggactgggcc   3660

gcgagtcagc ctctcgcctc actccccact cctcagcccc aaggtggcct ccatggatgc   3720

caaagacctg gccttgcaga tcttgccgcc ttgccaagtg cctcctccct ctgggcccca   3780

gagcccagct ggccctcaag ggctctcagc ccccgagcag caagaggatg aggacagcct   3840

ggaggaagac tcgcctcggg ccctgggctc gggccagcat tcggatagcc acggggagtc   3900

atcagccgag ctggacgagc aggacatctt ggctcctcag accgtgcagt gtccagccca   3960

ggccccagca ggcggcagtg aggagaccat cgccaaagcc aagcagagtc gcagtgagaa   4020

gaaggcccga aaggcaatgt caaagctggg cttgcggcag attcagggag tcaccaggat   4080

caccatccag aagtccaaga acatcctctt tgtcatcgcc aagcctgatg tcttcaagag   4140

cccagcctca gacacttatg tggtctttgg cgaggccaag attgaggacc tgtcccagca   4200

agtgcacaaa gccgcagctg agaagtttaa ggtgccctca gagccctcag ccttggtccc   4260

tgagtcagca cccaggcccc gggtgaggct ggagtgcaag gaagaggaag aggaggagga   4320

ggaagaggtg gacgaggcgg ggctggaact gcgtgacatt gagctggtga tggcgcaggc   4380

caatgtgtcc agggccaagg ccgtgcgggc tctgagagac aaccacagtg acatcgtcaa   4440

cgccatcatg gaactgacca tgtagccact gaccggaagc tggagccatc ctacgccttc   4500

cctcagctct gctactcaat aaatcggtgt cccttcattg ccctctggtg tctcctcctc   4560

gccctctgga gtcccatcat caccatctgg catcccttca cttccctctg gtgtcccttc   4620

accaccatct ggtgtcccct tactgccctg tggtgtccac tcattactct gtggtgtccc   4680

ctcactgccc tctggtgccc cctcatcacc ctctggtgtc ccttcatcac cctcttgtgt   4740

cccttccctc tggtgtcccc tcaccaccct ctgatgtccc ctcattactc tctggtgtca   4800

cctcaatact caccagtgtc ccctcactgc cctttggtgt cccctcatta ctctctggtg   4860

tcccctcacc gccctctggt gtcccctcaa tactccccgg tgtaccttca ccaccctctg   4920

gtgtcccctg ctctctggtg tcccaatact ctctgatgtc ccaatactct ctggtgtccc   4980

ctcattactc tctggtgtcc cctcactgcc ctctggtgtc cccgcaatac tctctggtgt   5040

cccctcacca ccctctggtg tctcaatact ctctggtgtc ccctcaccgc cttctgatgt   5100

cccctcacct tctgatgtca cctcattatc tctggtgtcc cctcaccacc ttctgatgtc   5160

ccctcattac tctctggtgt cccctcactg ccttctgatg tctcctcacc gccttctgat   5220

gtcccctcat tactctctga tgtcccctca ttactctctg gtgtcccctc accgccttct   5280

gatgtcccct caccgccttc tgatgtcccc tcaccacctt ctgatgtccc ctcattactc   5340

tctggtgtcc cctcaccgcc ttctgatgtc ccctcaccac cttctgatgt cccctcacca   5400

ccttctgatg tcccattact ctctgatgtc ccctcaccgc cttctgatgt cccattactc   5460

tctgatgtcc cctcaccgcc ttctgatgtc ccctcactgc cttctgatgt cccctcactc   5520

tctggtgtcc cctcaccgcc ttctgatgtc ccctcattac tctctggtgt cccctcaccg   5580

ccttctgata tctcaccacc ttctgatgtg ccctcattac tctctgatgt cccctcactg   5640

ccttctgatg tcccctcatt actctctggt gtcccctcac cgccttctga tgtcccctca   5700

ttactctctg atgtcccctc accgccttct gatgtcccct caccgccttc tgatatccca   5760

ttactctctg gtgtcccctc accgccttct gatgtcccct caccgccttc tgatgtcccc   5820

tcaccacctt ctgatgtccc attactctct ggtgtcccct caccgctttc tgatgtccca   5880

ttactctctg gtgtcccctc accgccttct gacgtcccct cattactgat gtcccctcac   5940

cgccttctga tgtcccatta ctctctggtg tcccctcacc gccttgatgt cccctcatta   6000

ctctctgatg tcccctcatt actctctggt gtcccctcat cgccctctgg tgtcccctca   6060

ctgccctctg gtgtcccaat actctccggt gtcccttcac tgccctctgg cgtcccctca   6120

ccttctggtg tccccattac tctctggtgt cccctcacca ccctctggtg tcccctcagt   6180

actctctggc gtcccttcac tgccctctgg tgtcccctca atactctccg gtgtcccctc   6240

atcgccctct ggtgtcccat caccctctga tgtcccctca ccaccctctc gtgcccctca   6300

ttactctctg gtgtcccttc accgccctct ggtgtcccct caccttctag tgtcccctca   6360

ttactctctg gtgtcccctc actactctct ggtgtcccct caccaccctc tggtgtcccc   6420

tcatcacctt ctgatgtccc atcactccct gatgtcccat tactccctgg tgtcccctca   6480

ctgccctctg gtgtcctgtc accaccctct gatgtccctt cattactctc tggtgtcccc   6540

tcattaccct ctggtgtccc ttcatctgct ccatgtcctc tactctttct gctagcaaag   6600

accagcgact gcagcacggg ggccacacct gggatggacc ctggaggggc aagcatgtgg   6660

ttcctttgac actccacaca gaaggcccat gcaaggccat gttcaaccag agggatggaa   6720

gggggacact gaaccttctg gcacagggtg ggctctggta gggggcaaga gcccaggaga   6780

ctgtgtggtt tgtcctcagc ctctcctgat gcttccaggg catgtccatt ttcatgtaaa   6840

cttaagagac agtgtcaaca gtaaagagcc tgctgcctgc cctggcctgg ggtcccatga   6900

gtaagcagct ctacaacagc ccagtacagt ggaaaaactc gcccataaaa cactgaccgg   6960

gccggccgcg gtggctcacg cctgtaatcc caacactttg ggaggcaggc ggatcacaaa   7020

gtcaggagtt tgagaccagc ctggccaata tggtgaaacc ccgtctctgc taaaaataca   7080

aaaattagct gggcgtggtg gcaggcgcct gtagtcccag ctactcggga ggctgagaca   7140

ggagaatcgc ttgaacccag gaggtgtagg ttgcagtgag ccaaaaccgc accactgcac   7200

tccaacctgg gcaacagagt gagactctgt cttgaga                            7237


<210>  3745
<211>  838
<212>  PRT
<213>  Homo sapiens

<400>  3745

Met Leu Leu Pro Glu Gly Leu Ser Ser Gln Ala Leu Ser Thr Glu Ala 
1               5                   10                  15


Pro Leu Pro Ala Thr Leu Glu Pro Arg Ile Val Met Gly Glu Glu Thr 
            20                  25                  30


Cys Gln Ala Leu Leu Ser Pro Arg Ala Ala Arg Thr Ala Leu Arg Asp 
        35                  40                  45


Gln Glu Gly Gly His Ala Ser Pro Asp Pro Pro Pro Glu Leu Cys Ser 
    50                  55                  60


Gln Gly Asp Leu Ser Val Pro Ser Pro Pro Pro Asp Pro Asp Ser Phe 
65                  70                  75                  80


Phe Thr Pro Pro Ser Thr Pro Thr Lys Thr Thr Tyr Ala Leu Leu Pro 
                85                  90                  95


Ala Cys Gly Pro His Gly Asp Ala Arg Asp Ser Glu Ala Glu Leu Arg 
            100                 105                 110


Asp Glu Leu Leu Asp Ser Pro Pro Ala Ser Pro Ser Gly Ser Tyr Ile 
        115                 120                 125


Thr Ala Asp Gly Asp Ser Trp Ala Ser Ser Pro Ser Cys Ser Leu Ser 
    130                 135                 140


Leu Leu Ala Pro Ala Glu Gly Leu Asp Phe Pro Ser Gly Trp Gly Leu 
145                 150                 155                 160


Ser Pro Gln Gly Ser Met Val Asp Glu Arg Glu Leu His Pro Ala Gly 
                165                 170                 175


Thr Pro Glu Pro Pro Ser Ser Glu Ser Ser Leu Ser Ala Asp Ser Ser 
            180                 185                 190


Ser Ser Trp Gly Gln Glu Gly His Phe Phe Asp Leu Asp Phe Leu Ala 
        195                 200                 205


Asn Asp Pro Met Ile Pro Ala Ala Leu Leu Pro Phe Gln Gly Ser Leu 
    210                 215                 220


Ile Phe Gln Val Glu Ala Val Glu Val Thr Pro Leu Ser Pro Glu Glu 
225                 230                 235                 240


Glu Glu Glu Glu Ala Val Ala Asp Pro Asp Pro Gly Gly Asp Leu Ala 
                245                 250                 255


Gly Glu Gly Glu Glu Asp Ser Thr Ser Ala Ser Phe Leu Gln Ser Leu 
            260                 265                 270


Ser Asp Leu Ser Ile Thr Glu Gly Met Asp Glu Ala Phe Ala Phe Arg 
        275                 280                 285


Asp Asp Thr Ser Ala Ala Ser Ser Asp Ser Asp Ser Ala Ser Tyr Ala 
    290                 295                 300


Glu Ala Asp Asp Glu Arg Leu Tyr Ser Gly Glu Pro His Ala Gln Ala 
305                 310                 315                 320


Thr Leu Leu Gln Asp Ser Val Gln Lys Thr Glu Glu Glu Ser Gly Gly 
                325                 330                 335


Gly Ala Lys Gly Leu Gln Ala Gln Asp Gly Thr Val Ser Trp Ala Val 
            340                 345                 350


Glu Ala Ala Pro Gln Thr Ser Asp Arg Gly Ala Tyr Leu Ser Gln Arg 
        355                 360                 365


Gln Glu Leu Ile Ser Glu Val Thr Glu Glu Gly Leu Ala Leu Gly Gln 
    370                 375                 380


Glu Ser Thr Ala Thr Val Thr Pro His Thr Leu Gln Val Ala Pro Gly 
385                 390                 395                 400


Leu Gln Val Glu Val Ala Thr Arg Val Thr Pro Gln Ala Gly Glu Glu 
                405                 410                 415


Glu Thr Asp Ser Thr Ala Gly Gln Glu Ser Ala Ala Met Ala Met Pro 
            420                 425                 430


Gln Pro Ser Gln Glu Gly Ile Ser Glu Ile Leu Gly Gln Glu Ser Val 
        435                 440                 445


Thr Ala Glu Lys Leu Pro Thr Pro Gln Glu Glu Thr Ser Leu Thr Leu 
    450                 455                 460


Cys Pro Asp Ser Pro Gln Asn Leu Lys Glu Glu Gly Gly Leu Asp Leu 
465                 470                 475                 480


Pro Ser Gly Arg Lys Pro Val Ala Ala Ala Thr Ile Val Pro Arg Gln 
                485                 490                 495


Ala Lys Glu Asp Leu Thr Leu Pro Gln Asp Ser Ala Met Thr Pro Pro 
            500                 505                 510


Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro Val Ala 
        515                 520                 525


Ala Ala Thr Ile Val Ser Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro 
    530                 535                 540


Gln Asp Ser Val Met Thr Pro Pro Leu Pro Leu Gln Asp Thr Glu Leu 
545                 550                 555                 560


Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr Leu Val Ser Gln Gln 
                565                 570                 575


Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr Pro Pro 
            580                 585                 590


Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro Val Ala 
        595                 600                 605


Ala Ala Thr Leu Val Ser Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro 
    610                 615                 620


Gln Asp Ser Ala Met Thr Pro Pro Leu Pro Leu Gln Asp Thr Asp Leu 
625                 630                 635                 640


Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr Leu Val Ser Gln Gln 
                645                 650                 655


Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr Pro Pro 
            660                 665                 670


Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro Val Ala 
        675                 680                 685


Ala Ala Thr Ile Val Ser Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro 
    690                 695                 700


Gln Asp Ser Ala Met Thr Pro Pro Leu Pro Leu Gln Asp Thr Asp Leu 
705                 710                 715                 720


Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr Ile Val Ser Gln Gln 
                725                 730                 735


Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr Pro Pro 
            740                 745                 750


Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro Val Ala 
        755                 760                 765


Ala Ala Thr Pro Val Ser Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro 
    770                 775                 780


Gln Asp Ser Ala Met Thr Pro Pro Leu Pro Leu Gln Asp Thr Asp Arg 
785                 790                 795                 800


Pro His Leu Arg Ser Arg Ala Ser Gly Cys Gly His Pro Ser Asn Leu 
                805                 810                 815


Ala Gly Arg Ser Arg Leu Cys Pro Arg Asp Arg Ala Cys Gly His His 
            820                 825                 830


Gly Ser Ala Gly Ser Arg 
        835


<210>  3746
<211>  2208
<212>  DNA
<213>  Homo sapiens

<400>  3746
caggcagcag gctctttact gttgacactg tctcttaagt ttacatgaaa atggacatgc     60

cctggaagca tcaggagagg ctgaggacaa accacacagt ctcctgggct cttgccccct    120

accagagccc accctgtgcc agaaggttca gtgtccccct tccatccctc tggttgaaca    180

tggccttgca tgggccttct gtgtggagtg tcaaaggaac cacatgcttg cccctccagg    240

gtccatccca ggtgtggccc ccgtgctgca gtcgctggtc tttgctagca gaaagagtag    300

aggacatgga gcagatgaag ggacaccaga gggtaatgag gggacaccag agagtaatga    360

agggacatca gagggtggtg acaggacacc agagggcagt gaggggacac cagggagtaa    420

tgggacatca gggagtgatg ggacatcaga aggtgatgag gggacaccag agggtggtga    480

ggggacacca gagagtagtg aggggacacc agagagtaat gaggggacac tagaaggtga    540

ggggacacca gagggcggtg aagggacacc agagagtaat gaggggcacg agagggtggt    600

gaggggacat cagagggtga tgggacacca gagggcgatg aggggacacc ggagagtatt    660

gaggggacac cagagggcag tgaagggacg ccagagagta ctgaggggac accagagggt    720

ggtgagggga caccagagag taatggggac accagaaggt gaggggacgc cagagggcag    780

tgaagggaca ccggagagta ttgggacacc agagggcagt gaggggacac cagagggcga    840

tgaggggaca ccagagagta atgaggggac atcagagagt aatgagggga catcaaggcg    900

gtgaggggac accagagagt aatgggacat cagaaggcgg tgaggggaca tcagtaatga    960

ggggacgtca gaaggcggtg aggggacacc agagagtaat gggacatcag aaagcggtga   1020

ggggacacca gagagtaatg ggacatcaga aggtggtgag gggacatcag aaggcggtga   1080

ggggacatca gaaggcggtg aggggacacc agagagtaat gggatatcag aaggcggtga   1140

ggggacatca gaaggcggtg aggggacatc agagagtaat gaggggacat cagaaggcgg   1200

tgaggggaca ccagagagta atgaggggac atcagaaggc agtgagggga catcagagag   1260

taatgagggc acatcagaag gtggtgagat atcagaaggc ggtgagggga caccagagag   1320

taatgagggg acatcagaag gcggtgaggg gacaccagag agtgagggga catcagaagg   1380

cagtgagggg acatcagaag gcggtgaggg gacatcagag agtaatggga catcagaagg   1440

cggtgagggg acatcagaga gtaatgggac atcagaaggt ggtgagggga catcagaagg   1500

tggtgagggg acatcagaag gcggtgaggg gacaccagag agtaatgagg ggacatcaga   1560

aggtggtgag gggacatcag aaggcggtga ggggacatca gaaggcggtg aggggacacc   1620

agagagtaat gaggggacat cagagagtaa tgaggggaca tcagaaggcg gtgaggagac   1680

atcagaaggc agtgagggga caccagagag taatgagggg acatcagaag gtggtgaggg   1740

gacaccagag agtaatgggg acatcagaag gcggtgaggg gacaccagag agtaatgagg   1800

agacatcaga aggcggtgag gggacatcgg agagtaatga ggggacatca gaaggcggtg   1860

aggggacacc agagagtaat gaggggacat cagaaggcgg tgaggggaca tcagaaggtg   1920

gtgaggggac accagagagt aatgagggga catcagaagg cggtgagggg acatcagtaa   1980

tgaggtgaca tcagaaggtg aggggacatc agaaggcggt gaggggacac cagagagtat   2040

tgagacacca gagggtggtg aggggacacc agagagtatt gcggggacac cagagggcag   2100

tgaggggaca ccagagagta atgaggggac accagagagt attgggacat cagagagtat   2160

tgggacacca gagagcaggg gacaccagag ggtggtgaag gtacaccg                2208


<210>  3747
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  3747

Met Arg Gly His Gln Arg Val Met Arg Gly His Gln Arg Val Met Arg 
1               5                   10                  15


Gly His Gln Gly Gly Glu Gly Thr Pro Glu Ser Asn Gly Thr Ser Glu 
            20                  25                  30


Gly Gly Glu Gly Thr Ser Val Met Arg Gly Arg Gln Lys Ala Val Arg 
        35                  40                  45


Gly His Gln Arg Val Met Gly His Gln Lys Ala Val Arg Gly His Gln 
    50                  55                  60


Arg Val Met Gly His Gln Lys Val Val Arg Gly His Gln Lys Ala Val 
65                  70                  75                  80


Arg Gly His Gln Lys Ala Val Arg Gly His Gln Arg Val Met Gly Tyr 
                85                  90                  95


Gln Lys Ala Val Arg Gly His Gln Lys Ala Val Arg Gly His Gln Arg 
            100                 105                 110


Val Met Arg Gly His Gln Lys Ala Val Arg Gly His Gln Arg Val Met 
        115                 120                 125


Arg Gly His Gln Lys Ala Val Arg Gly His Gln Arg Val Met Arg Ala 
    130                 135                 140


His Gln Lys Val Val Arg Tyr Gln Lys Ala Val Arg Gly His Gln Arg 
145                 150                 155                 160


Val Met Arg Gly His Gln Lys Ala Val Arg Gly His Gln Arg Val Arg 
                165                 170                 175


Gly His Gln Lys Ala Val Arg Gly His Gln Lys Ala Val Arg Gly His 
            180                 185                 190


Gln Arg Val Met Gly His Gln Lys Ala Val Arg Gly His Gln Arg Val 
        195                 200                 205


Met Gly His Gln Lys Val Val Arg Gly His Gln Lys Val Val Arg Gly 
    210                 215                 220


His Gln Lys Ala Val Arg Gly His Gln Arg Val Met Arg Gly His Gln 
225                 230                 235                 240


Lys Val Val Arg Gly His Gln Lys Ala Val Arg Gly His Gln Lys Ala 
                245                 250                 255


Val Arg Gly His Gln Arg Val Met Arg Gly His Gln Arg Val Met Arg 
            260                 265                 270


Gly His Gln Lys Ala Val Arg Arg His Gln Lys Ala Val Arg Gly His 
        275                 280                 285


Gln Arg Val Met Arg Gly His Gln Lys Val Val Arg Gly His Gln Arg 
    290                 295                 300


Val Met Gly Thr Ser Glu Gly Gly Glu Gly Thr Pro Glu Ser Asn Glu 
305                 310                 315                 320


Glu Thr Ser Glu Gly Gly Glu Gly Thr Ser Glu Ser Asn Glu Gly Thr 
                325                 330                 335


Ser Glu Gly Gly Glu Gly Thr Pro Glu Ser Asn Glu Gly Thr Ser Glu 
            340                 345                 350


Gly Gly Glu Gly Thr Ser Glu Gly Gly Glu Gly Thr Pro Glu Ser Asn 
        355                 360                 365


Glu Gly Thr Ser Glu Gly Gly Glu Gly Thr Ser Val Met Arg 
    370                 375                 380


<210>  3748
<211>  2022
<212>  DNA
<213>  Homo sapiens

<400>  3748
atgcttgccc ctccagggtc catcccaggt gtggcccccg tgctgcagtc gctggtcttt     60

gctagcagaa agagtagagg acatggagca gatgaaggga caccagaggg taatgagggg    120

acaccagaga gtaatgaagg gacatcagag ggtggtgaca ggacaccaga gggcagtgag    180

gggacaccag ggagtaatgg gacatcaggg agtgatggga catcagaagg tgatgagggg    240

acaccagagg gtggtgaggg gacaccagag agtagtgagg ggacaccaga gagtaatgag    300

gggacactag aaggtgaggg gacaccagag ggcggtgaag ggacaccaga gagtaatgag    360

gggcacgaga gggtggtgag gggacatcag agggtgatgg gacaccagag ggcgatgagg    420

ggacaccgga gagtattgag gggacaccag agggcagtga agggacgcca gagagtactg    480

aggggacacc agagggtggt gaggggacac cagagagtaa tggggacacc agaaggtgag    540

gggacgccag agggcagtga agggacaccg gagagtattg ggacaccaga gggcagtgag    600

gggacaccag agggcgatga ggggacacca gagagtaatg aggggacatc agagagtaat    660

gaggggacat caaggcgtaa tgaggggacg tcagaaggcg gtgaggggac accagagagt    720

aatgggacat cagaaagcgg tgaggggaca ccagagagta atgggacatc agaaggtggt    780

gaggggacat cagaaggcgg tgaggggaca tcagaaggcg gtgaggggac accagagagt    840

aatgggatat cagaaggcgg tgaggggaca tcagaaggcg gtgaggggac atcagagagt    900

aatgagggga catcagaagg cggtgagggg acaccagaga gtaatgaggg gacatcagaa    960

ggcagtgagg ggacatcaga gagtaatgag ggcacatcag aaggtggtga gatatcagaa   1020

ggcggtgagg ggacaccaga gagtaatgag gggacatcag aaggcggtga ggggacacca   1080

gagagtgagg ggacatcaga aggcagtgag gggacatcag aaggcggtga ggggacatca   1140

gagagtaatg ggacatcaga aggcggtgag gggacatcag agagtaatgg gacatcagaa   1200

ggtggtgagg ggacatcaga aggtggtgag gggacatcag aaggcggtga ggggacacca   1260

gagagtaatg aggggacatc agaaggtggt gaggggacat cagaaggcgg tgaggggaca   1320

tcagaaggcg gtgaggggac accagagagt aatgagggga catcagagag taatgagggg   1380

acatcagaag gcggtgagga gacatcagaa ggcagtgagg ggacaccaga gagtaatgag   1440

gggacatcag aaggtggtga ggggacacca gagagtaatg aggggacatc agaaggcggt   1500

gaggggacat cagtaatgag agagtattgg gacaccagag agcaggggac accagagggt   1560

ggtgaaggta caccggggag tattgagggg acaccagagg gcggtgaggg gacaccagag   1620

agtaatgagg ggacaccaaa gggcagtgag gggacactgg tgagtattga ggtgacacca   1680

gagagtaatg aggggacatc agagggtggt gaggggacac cagagggaag tgaggggaca   1740

cagggtgatg aagggacaca agagggtgat gaggggacac cagagggaag tgaggggaca   1800

caagagggtg atgaagggac accagagggt gatgaggggg caccagaggg cagtgagggg   1860

acaccacaga gtaatgagtg gacaccacag ggcagtaagg ggacaccaga tggtggtgaa   1920

gggacaccag agggaagtga agggatgcca gatggtgatg atgggactcc agagggcgag   1980

gaggagacac cagagggcaa tgaagggaca ccgatttatt ga                      2022


<210>  3749
<211>  673
<212>  PRT
<213>  Homo sapiens

<400>  3749

Met Leu Ala Pro Pro Gly Ser Ile Pro Gly Val Ala Pro Val Leu Gln 
1               5                   10                  15


Ser Leu Val Phe Ala Ser Arg Lys Ser Arg Gly His Gly Ala Asp Glu 
            20                  25                  30


Gly Thr Pro Glu Gly Asn Glu Gly Thr Pro Glu Ser Asn Glu Gly Thr 
        35                  40                  45


Ser Glu Gly Gly Asp Arg Thr Pro Glu Gly Ser Glu Gly Thr Pro Gly 
    50                  55                  60


Ser Asn Gly Thr Ser Gly Ser Asp Gly Thr Ser Glu Gly Asp Glu Gly 
65                  70                  75                  80


Thr Pro Glu Gly Gly Glu Gly Thr Pro Glu Ser Ser Glu Gly Thr Pro 
                85                  90                  95


Glu Ser Asn Glu Gly Thr Leu Glu Gly Glu Gly Thr Pro Glu Gly Gly 
            100                 105                 110


Glu Gly Thr Pro Glu Ser Asn Glu Gly His Glu Arg Val Val Arg Gly 
        115                 120                 125


His Gln Arg Val Met Gly His Gln Arg Ala Met Arg Gly His Arg Arg 
    130                 135                 140


Val Leu Arg Gly His Gln Arg Ala Val Lys Gly Arg Gln Arg Val Leu 
145                 150                 155                 160


Arg Gly His Gln Arg Val Val Arg Gly His Gln Arg Val Met Gly Thr 
                165                 170                 175


Pro Glu Gly Glu Gly Thr Pro Glu Gly Ser Glu Gly Thr Pro Glu Ser 
            180                 185                 190


Ile Gly Thr Pro Glu Gly Ser Glu Gly Thr Pro Glu Gly Asp Glu Gly 
        195                 200                 205


Thr Pro Glu Ser Asn Glu Gly Thr Ser Glu Ser Asn Glu Gly Thr Ser 
    210                 215                 220


Arg Arg Asn Glu Gly Thr Ser Glu Gly Gly Glu Gly Thr Pro Glu Ser 
225                 230                 235                 240


Asn Gly Thr Ser Glu Ser Gly Glu Gly Thr Pro Glu Ser Asn Gly Thr 
                245                 250                 255


Ser Glu Gly Gly Glu Gly Thr Ser Glu Gly Gly Glu Gly Thr Ser Glu 
            260                 265                 270


Gly Gly Glu Gly Thr Pro Glu Ser Asn Gly Ile Ser Glu Gly Gly Glu 
        275                 280                 285


Gly Thr Ser Glu Gly Gly Glu Gly Thr Ser Glu Ser Asn Glu Gly Thr 
    290                 295                 300


Ser Glu Gly Gly Glu Gly Thr Pro Glu Ser Asn Glu Gly Thr Ser Glu 
305                 310                 315                 320


Gly Ser Glu Gly Thr Ser Glu Ser Asn Glu Gly Thr Ser Glu Gly Gly 
                325                 330                 335


Glu Ile Ser Glu Gly Gly Glu Gly Thr Pro Glu Ser Asn Glu Gly Thr 
            340                 345                 350


Ser Glu Gly Gly Glu Gly Thr Pro Glu Ser Glu Gly Thr Ser Glu Gly 
        355                 360                 365


Ser Glu Gly Thr Ser Glu Gly Gly Glu Gly Thr Ser Glu Ser Asn Gly 
    370                 375                 380


Thr Ser Glu Gly Gly Glu Gly Thr Ser Glu Ser Asn Gly Thr Ser Glu 
385                 390                 395                 400


Gly Gly Glu Gly Thr Ser Glu Gly Gly Glu Gly Thr Ser Glu Gly Gly 
                405                 410                 415


Glu Gly Thr Pro Glu Ser Asn Glu Gly Thr Ser Glu Gly Gly Glu Gly 
            420                 425                 430


Thr Ser Glu Gly Gly Glu Gly Thr Ser Glu Gly Gly Glu Gly Thr Pro 
        435                 440                 445


Glu Ser Asn Glu Gly Thr Ser Glu Ser Asn Glu Gly Thr Ser Glu Gly 
    450                 455                 460


Gly Glu Glu Thr Ser Glu Gly Ser Glu Gly Thr Pro Glu Ser Asn Glu 
465                 470                 475                 480


Gly Thr Ser Glu Gly Gly Glu Gly Thr Pro Glu Ser Asn Glu Gly Thr 
                485                 490                 495


Ser Glu Gly Gly Glu Gly Thr Ser Val Met Arg Glu Tyr Trp Asp Thr 
            500                 505                 510


Arg Glu Gln Gly Thr Pro Glu Gly Gly Glu Gly Thr Pro Gly Ser Ile 
        515                 520                 525


Glu Gly Thr Pro Glu Gly Gly Glu Gly Thr Pro Glu Ser Asn Glu Gly 
    530                 535                 540


Thr Pro Lys Gly Ser Glu Gly Thr Leu Val Ser Ile Glu Val Thr Pro 
545                 550                 555                 560


Glu Ser Asn Glu Gly Thr Ser Glu Gly Gly Glu Gly Thr Pro Glu Gly 
                565                 570                 575


Ser Glu Gly Thr Gln Gly Asp Glu Gly Thr Gln Glu Gly Asp Glu Gly 
            580                 585                 590


Thr Pro Glu Gly Ser Glu Gly Thr Gln Glu Gly Asp Glu Gly Thr Pro 
        595                 600                 605


Glu Gly Asp Glu Gly Ala Pro Glu Gly Ser Glu Gly Thr Pro Gln Ser 
    610                 615                 620


Asn Glu Trp Thr Pro Gln Gly Ser Lys Gly Thr Pro Asp Gly Gly Glu 
625                 630                 635                 640


Gly Thr Pro Glu Gly Ser Glu Gly Met Pro Asp Gly Asp Asp Gly Thr 
                645                 650                 655


Pro Glu Gly Glu Glu Glu Thr Pro Glu Gly Asn Glu Gly Thr Pro Ile 
            660                 665                 670


Tyr 



<210>  3750
<211>  1530
<212>  DNA
<213>  Homo sapiens

<400>  3750
atgaggggac gtcagaaggc ggtgagggga caccagagag taatgggaca tcagaaagcg     60

gtgaggggac accagagagt aatgggacat cagaaggtgg tgaggggaca tcagaaggcg    120

gtgaggggac atcagaaggc ggtgagggga caccagagag taatgggata tcagaaggcg    180

gtgaggggac atcagaaggc ggtgagggga catcagagag taatgagggg acatcagaag    240

gcggtgaggg gacaccagag agtaatgagg ggacatcaga aggcagtgag gggacatcag    300

agagtaatga gggcacatca gaaggtggtg agatatcaga aggcggtgag gggacaccag    360

agagtaatga ggggacatca gaaggcggtg aggggacacc agagagtgag gggacatcag    420

aaggcagtga ggggacatca gaaggcggtg aggggacatc agagagtaat gggacatcag    480

aaggcggtga ggggacatca gagagtaatg ggacatcaga aggtggtgag gggacatcag    540

aaggtggtga ggggacatca gaaggcggtg aggggacacc agagagtaat gaggggacat    600

cagaaggtgg tgaggggaca tcagaaggcg gtgaggggac atcagaaggc ggtgagggga    660

caccagagag taatgagggg acatcagaga gtaatgaggg gacatcagaa ggcggtgagg    720

agacatcaga aggcagtgag gggacaccag agagtaatga ggggacatca gaaggtggtg    780

aggggacacc agagagtaat ggggacatca gaaggcggtg aggggacacc agagagtaat    840

gaggagacat cagaaggcgg tgaggggaca tcggagagta atgaggggac atcagaaggc    900

ggtgagggga caccagagag taatgagggg acatcagaag gcggtgaggg gacatcagaa    960

ggtggtgagg ggacaccaga gagtaatgag gggacatcag aaggcggtga ggggacatca   1020

gtaatgagag agtattggga caccagagag caggggacac cagagggtgg tgaaggtaca   1080

ccggggagta ttgaggggac accagagggc ggtgagggga caccagagag taatgagggg   1140

acaccaaagg gcagtgaggg gacactggtg agtattgagg tgacaccaga gagtaatgag   1200

gggacatcag agggtggtga ggggacacca gagggaagtg aggggacaca gggtgatgaa   1260

gggacacaag agggtgatga ggggacacca gagggaagtg aggggacaca agagggtgat   1320

gaagggacac cagagggtga tgagggggca ccagagggca gtgaggggac accacagagt   1380

aatgagtgga caccacaggg cagtaagggg acaccagatg gtggtgaagg gacaccagag   1440

ggaagtgaag ggatgccaga tggtgatgat gggactccag agggcgagga ggagacacca   1500

gagggcaatg aagggacacc gatttattga                                    1530


<210>  3751
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  3751

Met Arg Gly Arg Gln Lys Ala Val Arg Gly His Gln Arg Val Met Gly 
1               5                   10                  15


His Gln Lys Ala Val Arg Gly His Gln Arg Val Met Gly His Gln Lys 
            20                  25                  30


Val Val Arg Gly His Gln Lys Ala Val Arg Gly His Gln Lys Ala Val 
        35                  40                  45


Arg Gly His Gln Arg Val Met Gly Tyr Gln Lys Ala Val Arg Gly His 
    50                  55                  60


Gln Lys Ala Val Arg Gly His Gln Arg Val Met Arg Gly His Gln Lys 
65                  70                  75                  80


Ala Val Arg Gly His Gln Arg Val Met Arg Gly His Gln Lys Ala Val 
                85                  90                  95


Arg Gly His Gln Arg Val Met Arg Ala His Gln Lys Val Val Arg Tyr 
            100                 105                 110


Gln Lys Ala Val Arg Gly His Gln Arg Val Met Arg Gly His Gln Lys 
        115                 120                 125


Ala Val Arg Gly His Gln Arg Val Arg Gly His Gln Lys Ala Val Arg 
    130                 135                 140


Gly His Gln Lys Ala Val Arg Gly His Gln Arg Val Met Gly His Gln 
145                 150                 155                 160


Lys Ala Val Arg Gly His Gln Arg Val Met Gly His Gln Lys Val Val 
                165                 170                 175


Arg Gly His Gln Lys Val Val Arg Gly His Gln Lys Ala Val Arg Gly 
            180                 185                 190


His Gln Arg Val Met Arg Gly His Gln Lys Val Val Arg Gly His Gln 
        195                 200                 205


Lys Ala Val Arg Gly His Gln Lys Ala Val Arg Gly His Gln Arg Val 
    210                 215                 220


Met Arg Gly His Gln Arg Val Met Arg Gly His Gln Lys Ala Val Arg 
225                 230                 235                 240


Arg His Gln Lys Ala Val Arg Gly His Gln Arg Val Met Arg Gly His 
                245                 250                 255


Gln Lys Val Val Arg Gly His Gln Arg Val Met Gly Thr Ser Glu Gly 
            260                 265                 270


Gly Glu Gly Thr Pro Glu Ser Asn Glu Glu Thr Ser Glu Gly Gly Glu 
        275                 280                 285


Gly Thr Ser Glu Ser Asn Glu Gly Thr Ser Glu Gly Gly Glu Gly Thr 
    290                 295                 300


Pro Glu Ser Asn Glu Gly Thr Ser Glu Gly Gly Glu Gly Thr Ser Glu 
305                 310                 315                 320


Gly Gly Glu Gly Thr Pro Glu Ser Asn Glu Gly Thr Ser Glu Gly Gly 
                325                 330                 335


Glu Gly Thr Ser Val Met Arg Glu Tyr Trp Asp Thr Arg Glu Gln Gly 
            340                 345                 350


Thr Pro Glu Gly Gly Glu Gly Thr Pro Gly Ser Ile Glu Gly Thr Pro 
        355                 360                 365


Glu Gly Gly Glu Gly Thr Pro Glu Ser Asn Glu Gly Thr Pro Lys Gly 
    370                 375                 380


Ser Glu Gly Thr Leu Val Ser Ile Glu Val Thr Pro Glu Ser Asn Glu 
385                 390                 395                 400


Gly Thr Ser Glu Gly Gly Glu Gly Thr Pro Glu Gly Ser Glu Gly Thr 
                405                 410                 415


Gln Gly Asp Glu Gly Thr Gln Glu Gly Asp Glu Gly Thr Pro Glu Gly 
            420                 425                 430


Ser Glu Gly Thr Gln Glu Gly Asp Glu Gly Thr Pro Glu Gly Asp Glu 
        435                 440                 445


Gly Ala Pro Glu Gly Ser Glu Gly Thr Pro Gln Ser Asn Glu Trp Thr 
    450                 455                 460


Pro Gln Gly Ser Lys Gly Thr Pro Asp Gly Gly Glu Gly Thr Pro Glu 
465                 470                 475                 480


Gly Ser Glu Gly Met Pro Asp Gly Asp Asp Gly Thr Pro Glu Gly Glu 
                485                 490                 495


Glu Glu Thr Pro Glu Gly Asn Glu Gly Thr Pro Ile Tyr 
            500                 505


<210>  3752
<211>  263
<212>  DNA
<213>  Homo sapiens

<400>  3752
cctcaccacc ttctgatgtc ccctcaccgc cttctgatgt cccctcatta ctctctggtg     60

tcccctcacc gccttctgat gtcccctcat tactctccga tgtcccctca ccgccttctg    120

atgtctcctc attactctct ggtgtcccct caccgccttc tgatgtcccc attacgcctt    180

ctgatatctc accaccttct gatgtgccct cattactctc tgatgtcccc tcactgcctt    240

ctgatgtccc ctcattactc tct                                            263


<210>  3753
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  3753

Met Ser Pro His Arg Leu Leu Met Ser Pro His Tyr Ser Leu Val Ser 
1               5                   10                  15


Pro His Arg Leu Leu Met Ser Pro His Tyr Ser Pro Met Ser Pro His 
            20                  25                  30


Arg Leu Leu Met Ser Pro His Tyr Ser Leu Val Ser Pro His Arg Leu 
        35                  40                  45


Leu Met Ser Pro Leu Arg Leu Leu Ile Ser His His Leu Leu Met Cys 
    50                  55                  60


Pro His Tyr Ser Leu Met Ser Pro His Cys Leu Leu Met Ser Pro His 
65                  70                  75                  80


Tyr 



<210>  3754
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  3754
tggggaagga ccaaccacca gcccaaggtc ttggggaagt tggcggtgga gactttgcct     60

tcctgggcac tgtgctgctc tcctcccccg acgtgggtca acaccaggtc tgagcccccc    120

tctgccctct actcccaggc aatgtcaaag ctgggcttgc ggcagattca gggagtcacc    180

aggatcacca tccagaagtc caagaacatc ctctttgtca tcgccaagcc tgatgtcttc    240

aagagcccag cctcagacac ttatgtggtc tttggcgagg ccaagattga ggacctgtcc    300

cagcaagtgc acaaagccgc agctgagaag tttaaggtgc cctcagagcc ctcagccttg    360

gtccctgagt cagcacccag gccccgggtg aggctggagt gcaaggaaga ggaagaggag    420

gaggaggaag aggtggacga ggcggggctg gaactgcgtg acattgagct ggtgatggcg    480

caggccaatg tgtccagggc caaggccgtg cgggctctga gagacaacca cagtgacatc    540

gtcaacgcca tcatggaact gaccatgtag ccactgaccg gaagctggag ccatcctacg    600

ccttccctca gctctgctac tcaataaatc ggtgtccctt cattgccc                 648


<210>  3755
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  3755

Met Ser Lys Leu Gly Leu Arg Gln Ile Gln Gly Val Thr Arg Ile Thr 
1               5                   10                  15


Ile Gln Lys Ser Lys Asn Ile Leu Phe Val Ile Ala Lys Pro Asp Val 
            20                  25                  30


Phe Lys Ser Pro Ala Ser Asp Thr Tyr Val Val Phe Gly Glu Ala Lys 
        35                  40                  45


Ile Glu Asp Leu Ser Gln Gln Val His Lys Ala Ala Ala Glu Lys Phe 
    50                  55                  60


Lys Val Pro Ser Glu Pro Ser Ala Leu Val Pro Glu Ser Ala Pro Arg 
65                  70                  75                  80


Pro Arg Val Arg Leu Glu Cys Lys Glu Glu Glu Glu Glu Glu Glu Glu 
                85                  90                  95


Glu Val Asp Glu Ala Gly Leu Glu Leu Arg Asp Ile Glu Leu Val Met 
            100                 105                 110


Ala Gln Ala Asn Val Ser Arg Ala Lys Ala Val Arg Ala Leu Arg Asp 
        115                 120                 125


Asn His Ser Asp Ile Val Asn Ala Ile Met Glu Leu Thr Met 
    130                 135                 140


<210>  3756
<211>  4498
<212>  DNA
<213>  Homo sapiens

<400>  3756
ggggaccggc gggagccctg tgctctgacc ccagggccca gccacctggc cctcacgttc     60

ctgcccagca agccgggtgc ccggccccag cccgagggag ccagctggga tgcagggcct    120

ggtggggcac cctcggcctg ggcggaccca ggggagggcg gcccaagccc catgctcctc    180

cctgagggcc tgtcttccca ggctctgtcc acggaggctc ctctcccggc caccctggag    240

ccccggattg tgatgggaga ggagacgtgc caggccctcc tgtcacccag agctgcccgg    300

acagcgctca gggaccagga gggtgggcac gcaagcccag acccaccccc cgagctgtgt    360

tctcagggtg atctttctgt gccttcccct cccccagacc ctgattcctt cttcacgcct    420

ccctccaccc ccaccaagac cacctatgcc ctgcttcctg cctgtgggcc ccacggggac    480

gccagggact cagaggctga gctgcgggat gagctgctgg actcgccccc cgcctcaccc    540

tcgggctcct acattacggc cgatggggac agctgggcct cttcaccctc ctgttccctc    600

agcctgctgg ctccggctga agggctggac ttcccctcag gctggggcct gtccccgcag    660

gggtccatgg tggatgaacg agagctgcac ccagcaggga ccccagagcc cccgtcctct    720

gagtccagcc tctctgcaga cagcagctcc tcctggggcc aggagggcca cttcttcgac    780

ctggacttcc tggccaatga cccaatgatc cccgcagccc tcctaccctt ccagggcagc    840

ctcatctttc aggtggaggc agtggaggtg acaccgctat ccccagagga agaagaagag    900

gaggctgtgg cggatcccga cccaggtggg gacctggctg gggagggtga ggaggacagc    960

acgtctgcct ccttcctgca gtcactgtct gacctgtcca tcacggaggg catggacgag   1020

gcttttgcct tccgggacga cacctctgca gcctcctctg attcagactc agcctcctac   1080

gcagaggcag atgatgagag gctgtacagc ggggagcccc atgcccaggc cactttgctc   1140

caggacagtg tccagaagac agaggaggag agcggaggtg gggccaaggg gctgcaggct   1200

caggatggga ctgtgtcctg ggccgtggag gctgctcctc agacctcaga cagaggggcc   1260

tatctgtccc agagacagga attgatctca gaagtaacag aagagggcct tgctttaggc   1320

caggagtcca ctgccactgt gacccctcac actctgcagg tagccccagg cctccaggtg   1380

gaggtggcta ccagagtgac cccacaggct ggggaggaag aaacagactc caccgctgga   1440

caagaatctg ctgccatggc aatgcctcag ccctcccagg agggcatcag cgagatctta   1500

ggccaagagt ctgtcactgc agaaaaactt ccaactccac aggaagaaac aagcctcaca   1560

ttgtgtccag actctcctca gaacttgaag gaagaaggag ggctggacct cccctctggc   1620

agaaagcctg tagctgcagc cacgattgtc cccaggcagg ctaaagagga cctcacctta   1680

ccccaggact ccgctatgac accgcctctg cccctacaag acacagatct ctcatcagcc   1740

ccaaagcctg tggctgcagc cacgattgtg tcccagcagg ctgaagaggg cctcacctta   1800

ccccaggact ccgttatgac accgcctctg cccctacaag acacagaact ctcgtcagcc   1860

ccaaagcctg tggctgcagc cacgcttgtg tcccagcagg ctgaagaggg cctcacctta   1920

ccccaggact ccgctatgac accgcctctg cccctacaag acacagatct ctcgtcagcc   1980

ccaaagcctg tggctgcagc cacgcttgtg tcccagcagg ctgaagaggg cctcacctta   2040

ccccaggact ccgctatgac accgcctctg cccctacaag acacagatct ctcgtcagcc   2100

ccaaagcctg tggctgcagc cacgcttgtg tcccagcagg ctgaagaggg cctcacctta   2160

ccccaggact ccgctatgac accgcctctg cccctacaag acacagatct ctcgtcagcc   2220

ccaaagcctg tggctgcagc cacgattgtg tcccagcagg ctgaagaggg cctcacctta   2280

ccccaggact ccgctatgac accgcctctg cccctacaag acacagatct ctcgtcagcc   2340

ccaaagcctg tggctgcagc cacgattgtg tcccagcagg ctgaagaggg cctcacctta   2400

ccccaggact ccgctatgac accgcctctg cccctacaag acacagatct ctcgtcagcc   2460

ccaaagcctg tggctgcagc cacgcctgtg tcccagcagg ctgaagaggg cctcacctta   2520

ccccaggact ccgctatgac accgcctctg cccctacaag acacagatag gccccacctc   2580

aggtccagag cctctggctg tggccacccc tcaaaccttg caggcagaag caggctgtgc   2640

cccagggaca gagcctgtgg ccaccatggc tcagcaggaa gtaggtgagg ccttaggccc   2700

caggccagca cctgaggaga agaatgcagc cctccctaca gtcccggagc ctgcagcctt   2760

ggaccaggtc caacaggatg acccacagcc agctgcagaa gctgggacac cttgggccgc   2820

acaggaagat gcggattcca ctttgggcat ggaggccctc agtctccctg agccggcctc   2880

tggtgctggg gaggaaatag cagaagccct ttctaggcct ggacgggaag catgtctgga   2940

agcgcgagcg cacacaggtg atggggctaa gcctgactca ccccaaaagg agaccctgga   3000

ggttgagaac cagcaggaag gaggcctgaa gccactggca caggaacatg gacccaggtc   3060

agcacttgga ggtgcaaggg aggtccccga tgcgcctcct gctgcctgcc ctgaggtcag   3120

ccaggcccgg ctcctgagcc cagccaggga ggaaagaggc ctgagtggca agtccacccc   3180

ggagcccacg cttccctcag ctgtggccac agaggccagt ctggactcct gcccagagtc   3240

ttcagtaggg gctgtgtcca gtctggacag aggctgccct gacgcgcctg cccccacgtc   3300

tgcaccaacc tcccagcagc cggagcctgt actgggtctg ggcagtgttg agcaacccca   3360

cgaagtaccc agtgtccttg gcaccccctt gctgcagccc ccagaaaacc ttgccaaggg   3420

tcagcccagc acgcccgtgg acaggcccct gggccctgac ccttctgctc ctggtaccct   3480

tgctggggca gccctacccc cactggagcc cccagccccc tgcctgtgcc aggaccccca   3540

ggaagactct gtggaagacg aggagccccc aggctctctg ggcctcccac cgccccaggc   3600

aggagtccag cctgccgctg ctgctgtctc aggaaccaca cagcctctgg ggactgggcc   3660

gcgagtcagc ctctcgcctc actccccact cctcagcccc aaggtggcct ccatggatgc   3720

caaagacctg gccttgcaga tcttgccgcc ttgccaagtg cctcctccct ctgggcccca   3780

gagcccagct ggccctcaag ggctctcagc ccccgagcag caagaggatg aggacagcct   3840

ggaggaagac tcgcctcggg ccctgggctc gggccagcat tcggatagcc acggggagtc   3900

atcagccgag ctggacgagc aggacatctt ggctcctcag accgtgcagt gtccagccca   3960

ggccccagca ggcggcagtg aggagaccat cgccaaagcc aagcagagtc gcagtgagaa   4020

gaaggcccga aaggcaatgt caaagctggg cttgcggcag attcagggag tcaccaggat   4080

caccatccag aagtccaaga acatcctctt tgtcatcgcc aagcctgatg tcttcaagag   4140

cccagcctca gacacttatg tggtctttgg cgaggccaag attgaggacc tgtcccagca   4200

agtgcacaaa gccgcagctg agaagtttaa ggtgccctca gagccctcag ccttggtccc   4260

tgagtcagca cccaggcccc gggtggacga ggcggggctg gaactgcgtg acattgagct   4320

ggtgatggcg caggccaatg tgtccagggc caaggccgtg cgggctctga gagacaacca   4380

cagtgacatc gtcaacgcca tcatggaact gaccatgtag ccactgaccg gaagctggag   4440

ccatcctacg ccttccctca gctctgctac tcaataaatc ggtgtccctt cattgccc     4498


<210>  3757
<211>  838
<212>  PRT
<213>  Homo sapiens

<400>  3757

Met Leu Leu Pro Glu Gly Leu Ser Ser Gln Ala Leu Ser Thr Glu Ala 
1               5                   10                  15


Pro Leu Pro Ala Thr Leu Glu Pro Arg Ile Val Met Gly Glu Glu Thr 
            20                  25                  30


Cys Gln Ala Leu Leu Ser Pro Arg Ala Ala Arg Thr Ala Leu Arg Asp 
        35                  40                  45


Gln Glu Gly Gly His Ala Ser Pro Asp Pro Pro Pro Glu Leu Cys Ser 
    50                  55                  60


Gln Gly Asp Leu Ser Val Pro Ser Pro Pro Pro Asp Pro Asp Ser Phe 
65                  70                  75                  80


Phe Thr Pro Pro Ser Thr Pro Thr Lys Thr Thr Tyr Ala Leu Leu Pro 
                85                  90                  95


Ala Cys Gly Pro His Gly Asp Ala Arg Asp Ser Glu Ala Glu Leu Arg 
            100                 105                 110


Asp Glu Leu Leu Asp Ser Pro Pro Ala Ser Pro Ser Gly Ser Tyr Ile 
        115                 120                 125


Thr Ala Asp Gly Asp Ser Trp Ala Ser Ser Pro Ser Cys Ser Leu Ser 
    130                 135                 140


Leu Leu Ala Pro Ala Glu Gly Leu Asp Phe Pro Ser Gly Trp Gly Leu 
145                 150                 155                 160


Ser Pro Gln Gly Ser Met Val Asp Glu Arg Glu Leu His Pro Ala Gly 
                165                 170                 175


Thr Pro Glu Pro Pro Ser Ser Glu Ser Ser Leu Ser Ala Asp Ser Ser 
            180                 185                 190


Ser Ser Trp Gly Gln Glu Gly His Phe Phe Asp Leu Asp Phe Leu Ala 
        195                 200                 205


Asn Asp Pro Met Ile Pro Ala Ala Leu Leu Pro Phe Gln Gly Ser Leu 
    210                 215                 220


Ile Phe Gln Val Glu Ala Val Glu Val Thr Pro Leu Ser Pro Glu Glu 
225                 230                 235                 240


Glu Glu Glu Glu Ala Val Ala Asp Pro Asp Pro Gly Gly Asp Leu Ala 
                245                 250                 255


Gly Glu Gly Glu Glu Asp Ser Thr Ser Ala Ser Phe Leu Gln Ser Leu 
            260                 265                 270


Ser Asp Leu Ser Ile Thr Glu Gly Met Asp Glu Ala Phe Ala Phe Arg 
        275                 280                 285


Asp Asp Thr Ser Ala Ala Ser Ser Asp Ser Asp Ser Ala Ser Tyr Ala 
    290                 295                 300


Glu Ala Asp Asp Glu Arg Leu Tyr Ser Gly Glu Pro His Ala Gln Ala 
305                 310                 315                 320


Thr Leu Leu Gln Asp Ser Val Gln Lys Thr Glu Glu Glu Ser Gly Gly 
                325                 330                 335


Gly Ala Lys Gly Leu Gln Ala Gln Asp Gly Thr Val Ser Trp Ala Val 
            340                 345                 350


Glu Ala Ala Pro Gln Thr Ser Asp Arg Gly Ala Tyr Leu Ser Gln Arg 
        355                 360                 365


Gln Glu Leu Ile Ser Glu Val Thr Glu Glu Gly Leu Ala Leu Gly Gln 
    370                 375                 380


Glu Ser Thr Ala Thr Val Thr Pro His Thr Leu Gln Val Ala Pro Gly 
385                 390                 395                 400


Leu Gln Val Glu Val Ala Thr Arg Val Thr Pro Gln Ala Gly Glu Glu 
                405                 410                 415


Glu Thr Asp Ser Thr Ala Gly Gln Glu Ser Ala Ala Met Ala Met Pro 
            420                 425                 430


Gln Pro Ser Gln Glu Gly Ile Ser Glu Ile Leu Gly Gln Glu Ser Val 
        435                 440                 445


Thr Ala Glu Lys Leu Pro Thr Pro Gln Glu Glu Thr Ser Leu Thr Leu 
    450                 455                 460


Cys Pro Asp Ser Pro Gln Asn Leu Lys Glu Glu Gly Gly Leu Asp Leu 
465                 470                 475                 480


Pro Ser Gly Arg Lys Pro Val Ala Ala Ala Thr Ile Val Pro Arg Gln 
                485                 490                 495


Ala Lys Glu Asp Leu Thr Leu Pro Gln Asp Ser Ala Met Thr Pro Pro 
            500                 505                 510


Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro Val Ala 
        515                 520                 525


Ala Ala Thr Ile Val Ser Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro 
    530                 535                 540


Gln Asp Ser Val Met Thr Pro Pro Leu Pro Leu Gln Asp Thr Glu Leu 
545                 550                 555                 560


Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr Leu Val Ser Gln Gln 
                565                 570                 575


Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr Pro Pro 
            580                 585                 590


Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro Val Ala 
        595                 600                 605


Ala Ala Thr Leu Val Ser Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro 
    610                 615                 620


Gln Asp Ser Ala Met Thr Pro Pro Leu Pro Leu Gln Asp Thr Asp Leu 
625                 630                 635                 640


Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr Leu Val Ser Gln Gln 
                645                 650                 655


Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr Pro Pro 
            660                 665                 670


Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro Val Ala 
        675                 680                 685


Ala Ala Thr Ile Val Ser Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro 
    690                 695                 700


Gln Asp Ser Ala Met Thr Pro Pro Leu Pro Leu Gln Asp Thr Asp Leu 
705                 710                 715                 720


Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr Ile Val Ser Gln Gln 
                725                 730                 735


Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr Pro Pro 
            740                 745                 750


Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro Val Ala 
        755                 760                 765


Ala Ala Thr Pro Val Ser Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro 
    770                 775                 780


Gln Asp Ser Ala Met Thr Pro Pro Leu Pro Leu Gln Asp Thr Asp Arg 
785                 790                 795                 800


Pro His Leu Arg Ser Arg Ala Ser Gly Cys Gly His Pro Ser Asn Leu 
                805                 810                 815


Ala Gly Arg Ser Arg Leu Cys Pro Arg Asp Arg Ala Cys Gly His His 
            820                 825                 830


Gly Ser Ala Gly Ser Arg 
        835


<210>  3758
<211>  5313
<212>  DNA
<213>  Homo sapiens

<400>  3758
atgataggac agatcaccga gttgcctaga gacctggaga ccgacccatc cgggtcgcct     60

tccctggtgc gctctcgtcg gctccatccc tggttgccat ggagacagga ggcggttgcc    120

acggagaccg acgactgcca ggaccagcca atcactccag agctgcagct ccagctcacc    180

ttttgcatgg agtgcctggc gagcccgcgc acgctcactc gctgggacag gcgggcgggg    240

cggcctgacg tcacccactg cccccaccgc ccggccgagg ggcggtggcc gcgcaggctc    300

ggcggggcgg cggcacggac tgacggaggg tcggaaggac tgagggacgg gcgggcgcac    360

ggccaggcca tgcctgggga ggctgcccgc gccgagctgc tgctgcccga ggcggaccga    420

cccgggcccc gcacagaact gcggggaagg tggggcgcac gaagtgcccg ccgcgagcca    480

gaaagaacgt gggggcttaa gcccttggct tccgacccag ggatcgtggg gctcgcatcc    540

cgcccgctgc atcccgttgt ttgcaccgag ctgccagcct gctggggctg ggccgctctg    600

gacagaggca gcgggttctg gaggcggggt gtccggctga tacccccagt acgatcagat    660

ctgtcctgcg atgcggccgc tgccaccacc atcctgggag gggaccggcg ggagccctgt    720

gctctgaccc cagggcccag ccacctggcc ctcacgttcc tgcccagcaa gccgggtgcc    780

cggccccagc ccgagggagc cagctgggat gcagggcctg gtggggcacc ctcggcctgg    840

gcggacccag gggagggcgg cccaagcccc atgctcctcc ctgagggcct gtcttcccag    900

gctctgtcca cggaggctcc tctcccggcc accctggagc cccggattgt gatgggagag    960

gagacgtgcc aggccctcct gtcacccaga gctgcccgga cagcgctcag ggaccaggag   1020

ggtgggcacg caagcccaga cccacccccc gagctgtgtt ctcagggtga tctttctgtg   1080

ccttcccctc ccccagaccc tgattccttc ttcacgcctc cctccacccc caccaagacc   1140

acctatgccc tgcttcctgc ctgtgggccc cacggggacg ccagggactc agaggctgag   1200

ctgcgggatg agctgctgga ctcgcccccc gcctcaccct cgggctccta cattacggcc   1260

gatggggaca gctgggcctc ttcaccctcc tgttccctca gcctgctggc tccggctgaa   1320

gggctggact tcccctcagg ctggggcctg tccccgcagg ggtccatggt ggatgaacga   1380

gagctgcacc cagcagggac cccagagccc ccgtcctctg agtccagcct ctctgcagac   1440

agcagctcct cctggggcca ggagggccac ttcttcgacc tggacttcct ggccaatgac   1500

ccaatgatcc ccgcagccct cctacccttc cagggcagcc tcatctttca ggtggaggca   1560

gtggaggtga caccgctatc cccagaggaa gaagaagagg aggctgtggc ggatcccgac   1620

ccaggtgggg acctggctgg ggagggtgag gaggacagca cgtctgcctc cttcctgcag   1680

tcactgtctg acctgtccat cacggagggc atggacgagg cttttgcctt ccgggacgac   1740

acctctgcag cctcctctga ttcagactca gcctcctacg cagaggcaga tgatgagagg   1800

ctgtacagcg gggagcccca tgcccaggcc actttgctcc aggacagtgt ccagaagaca   1860

gaggaggaga gcggaggtgg ggccaagggg ctgcaggctc aggatgggac tgtgtcctgg   1920

gccgtggagg ctgctcctca gacctcagac agaggggcct atctgtccca gagacaggaa   1980

ttgatctcag aagtaacaga agagggcctt gctttaggcc aggagtccac tgccactgtg   2040

acccctcaca ctctgcaggt agccccaggc ctccaggtgg aggtggctac cagagtgacc   2100

ccacaggctg gggaggaaga aacagactcc accgctggac aagaatctgc tgccatggca   2160

atgcctcagc cctcccagga gggcatcagc gagatcttag gccaagagtc tgtcactgca   2220

gaaaaacttc caactccaca ggaagaaaca agcctcacat tgtgtccaga ctctcctcag   2280

aacttgaagg aagaaggagg gctggacctc ccctctggca gaaagcctgt agctgcagcc   2340

acgattgtcc ccaggcaggc taaagaggac ctcaccttac cccaggactc cgctatgaca   2400

ccgcctctgc ccctacaaga cacagatctc tcatcagccc caaagcctgt ggctgcagcc   2460

acgattgtgt cccagcaggc tgaagagggc ctcaccttac cccaggactc cgttatgaca   2520

ccgcctctgc ccctacaaga cacagaactc tcgtcagccc caaagcctgt ggctgcagcc   2580

acgcttgtgt cccagcaggc tgaagagggc ctcaccttac cccaggactc cgctatgaca   2640

ccgcctctgc ccctacaaga cacagatctc tcgtcagccc caaagcctgt ggctgcagcc   2700

acgcttgtgt cccagcaggc tgaagagggc ctcaccttac cccaggactc cgctatgaca   2760

ccgcctctgc ccctacaaga cacagatctc tcgtcagccc caaagcctgt ggctgcagcc   2820

acgcttgtgt cccagcaggc tgaagagggc ctcaccttac cccaggactc cgctatgaca   2880

ccgcctctgc ccctacaaga cacagatctc tcgtcagccc caaagcctgt ggctgcagcc   2940

acgattgtgt cccagcaggc tgaagagggc ctcaccttac cccaggactc cgctatgaca   3000

ccgcctctgc ccctacaaga cacagatctc tcgtcagccc caaagcctgt ggctgcagcc   3060

acgattgtgt cccagcaggc tgaagagggc ctcaccttac cccaggactc cgctatgaca   3120

ccgcctctgc ccctacaaga cacagatctc tcgtcagccc caaagcctgt ggctgcagcc   3180

acgcctgtgt cccagcaggc tgaagagggc ctcaccttac cccaggactc cgctatgaca   3240

ccgcctctgc ccctacaaga cacagatctc tcgtcagccc caaagcctgt ggctgcagcc   3300

acgcctgtgt cccagcaggc tgaagagggc ctcaccttac cccaggactc cgctatgaca   3360

gcacctctgc ctctgcaaga cacaggcccc acctcaggtc cagagcctct ggctgtggcc   3420

acccctcaaa ccttgcaggc agaagcaggc tgtgccccag ggacagagcc tgtggccacc   3480

atggctcagc aggaagtagg tgaggcctta ggccccaggc cagcacctga ggagaagaat   3540

gcagccctcc ctacagtccc ggagcctgca gccttggacc aggtccaaca ggatgaccca   3600

cagccagctg cagaagctgg gacaccttgg gccgcacagg aagatgcgga ttccactttg   3660

ggcatggagg ccctcagtct ccctgagccg gcctctggtg ctggggagga aatagcagaa   3720

gccctttcta ggcctggacg ggaagcatgt ctggaagcgc gagcgcacac aggtgatggg   3780

gctaagcctg actcacccca aaaggagacc ctggaggttg agaaccagca ggaaggaggc   3840

ctgaagccac tggcacagga acatggaccc aggtcagcac ttggaggtgc aagggaggtc   3900

cccgatgcgc ctcctgctgc ctgccctgag gtcagccagg cccggctcct gagcccagcc   3960

agggaggaaa gaggcctgag tggcaagtcc accccggagc ccacgcttcc ctcagctgtg   4020

gccacagagg ccagtctgga ctcctgccca gagtcttcag taggggctgt gtccagtctg   4080

gacagaggct gccctgacgc gcctgccccc acgtctgcac caacctccca gcagccggag   4140

cctgtactgg gtctgggcag tgttgagcaa ccccacgaag tacccagtgt ccttggcacc   4200

cccttgctgc agcccccaga aaaccttgcc aagggtcagc ccagcacgcc cgtggacagg   4260

cccctgggcc ctgacccttc tgctcctggt acccttgctg gggcagccct acccccactg   4320

gagcccccag ccccctgcct gtgccaggac ccccaggaag actctgtgga agacgaggag   4380

cccccaggct ctctgggcct cccaccgccc caggcaggag tccagcctgc cgctgctgct   4440

gtctcaggaa ccacacagcc tctggggact gggccgcgag tcagcctctc gcctcactcc   4500

ccactcctca gccccaaggt ggcctccatg gatgccaaag acctggcctt gcagatcttg   4560

ccgccttgcc aagtgcctcc tccctctggg ccccagagcc cagctggccc tcaagggctc   4620

tcagcccccg agcagcaaga ggatgaggac agcctggagg aagactcgcc tcgggccctg   4680

ggctcgggcc agcattcgga tagccacggg gagtcatcag ccgagctgga cgagcaggac   4740

atcttggctc ctcagaccgt gcagtgtcca gcccaggccc cagcaggcgg cagtgaggag   4800

accatcgcca aagccaagca gagtcgcagt gagaagaagg cccgaaaggc aatgtcaaag   4860

ctgggcttgc ggcagattca gggagtcacc aggatcacca tccagaagtc caagaacatc   4920

ctctttgtca tcgccaagcc tgatgtcttc aagagcccag cctcagacac ttatgtggtc   4980

tttggcgagg ccaagattga ggacctgtcc cagcaagtgc acaaagccgc agctgagaag   5040

tttaaggtgc cctcagagcc ctcagccttg gtccctgagt cagcacccag gccccgggtg   5100

gacgaggcgg ggctggaact gcgtgacatt gagctggtga tggcgcaggc caatgtgtcc   5160

agggccaagg ccgtgcgggc tctgagagac aaccacagtg acatcgtcaa cgccatcatg   5220

gaactgacca tgtagccact gaccggaagc tggagccatc ctacgccttc cctcagctct   5280

gctactcaat aaatcggtgt cccttcattg ccc                                5313


<210>  3759
<211>  1744
<212>  PRT
<213>  Homo sapiens

<400>  3759

Met Ile Gly Gln Ile Thr Glu Leu Pro Arg Asp Leu Glu Thr Asp Pro 
1               5                   10                  15


Ser Gly Ser Pro Ser Leu Val Arg Ser Arg Arg Leu His Pro Trp Leu 
            20                  25                  30


Pro Trp Arg Gln Glu Ala Val Ala Thr Glu Thr Asp Asp Cys Gln Asp 
        35                  40                  45


Gln Pro Ile Thr Pro Glu Leu Gln Leu Gln Leu Thr Phe Cys Met Glu 
    50                  55                  60


Cys Leu Ala Ser Pro Arg Thr Leu Thr Arg Trp Asp Arg Arg Ala Gly 
65                  70                  75                  80


Arg Pro Asp Val Thr His Cys Pro His Arg Pro Ala Glu Gly Arg Trp 
                85                  90                  95


Pro Arg Arg Leu Gly Gly Ala Ala Ala Arg Thr Asp Gly Gly Ser Glu 
            100                 105                 110


Gly Leu Arg Asp Gly Arg Ala His Gly Gln Ala Met Pro Gly Glu Ala 
        115                 120                 125


Ala Arg Ala Glu Leu Leu Leu Pro Glu Ala Asp Arg Pro Gly Pro Arg 
    130                 135                 140


Thr Glu Leu Arg Gly Arg Trp Gly Ala Arg Ser Ala Arg Arg Glu Pro 
145                 150                 155                 160


Glu Arg Thr Trp Gly Leu Lys Pro Leu Ala Ser Asp Pro Gly Ile Val 
                165                 170                 175


Gly Leu Ala Ser Arg Pro Leu His Pro Val Val Cys Thr Glu Leu Pro 
            180                 185                 190


Ala Cys Trp Gly Trp Ala Ala Leu Asp Arg Gly Ser Gly Phe Trp Arg 
        195                 200                 205


Arg Gly Val Arg Leu Ile Pro Pro Val Arg Ser Asp Leu Ser Cys Asp 
    210                 215                 220


Ala Ala Ala Ala Thr Thr Ile Leu Gly Gly Asp Arg Arg Glu Pro Cys 
225                 230                 235                 240


Ala Leu Thr Pro Gly Pro Ser His Leu Ala Leu Thr Phe Leu Pro Ser 
                245                 250                 255


Lys Pro Gly Ala Arg Pro Gln Pro Glu Gly Ala Ser Trp Asp Ala Gly 
            260                 265                 270


Pro Gly Gly Ala Pro Ser Ala Trp Ala Asp Pro Gly Glu Gly Gly Pro 
        275                 280                 285


Ser Pro Met Leu Leu Pro Glu Gly Leu Ser Ser Gln Ala Leu Ser Thr 
    290                 295                 300


Glu Ala Pro Leu Pro Ala Thr Leu Glu Pro Arg Ile Val Met Gly Glu 
305                 310                 315                 320


Glu Thr Cys Gln Ala Leu Leu Ser Pro Arg Ala Ala Arg Thr Ala Leu 
                325                 330                 335


Arg Asp Gln Glu Gly Gly His Ala Ser Pro Asp Pro Pro Pro Glu Leu 
            340                 345                 350


Cys Ser Gln Gly Asp Leu Ser Val Pro Ser Pro Pro Pro Asp Pro Asp 
        355                 360                 365


Ser Phe Phe Thr Pro Pro Ser Thr Pro Thr Lys Thr Thr Tyr Ala Leu 
    370                 375                 380


Leu Pro Ala Cys Gly Pro His Gly Asp Ala Arg Asp Ser Glu Ala Glu 
385                 390                 395                 400


Leu Arg Asp Glu Leu Leu Asp Ser Pro Pro Ala Ser Pro Ser Gly Ser 
                405                 410                 415


Tyr Ile Thr Ala Asp Gly Asp Ser Trp Ala Ser Ser Pro Ser Cys Ser 
            420                 425                 430


Leu Ser Leu Leu Ala Pro Ala Glu Gly Leu Asp Phe Pro Ser Gly Trp 
        435                 440                 445


Gly Leu Ser Pro Gln Gly Ser Met Val Asp Glu Arg Glu Leu His Pro 
    450                 455                 460


Ala Gly Thr Pro Glu Pro Pro Ser Ser Glu Ser Ser Leu Ser Ala Asp 
465                 470                 475                 480


Ser Ser Ser Ser Trp Gly Gln Glu Gly His Phe Phe Asp Leu Asp Phe 
                485                 490                 495


Leu Ala Asn Asp Pro Met Ile Pro Ala Ala Leu Leu Pro Phe Gln Gly 
            500                 505                 510


Ser Leu Ile Phe Gln Val Glu Ala Val Glu Val Thr Pro Leu Ser Pro 
        515                 520                 525


Glu Glu Glu Glu Glu Glu Ala Val Ala Asp Pro Asp Pro Gly Gly Asp 
    530                 535                 540


Leu Ala Gly Glu Gly Glu Glu Asp Ser Thr Ser Ala Ser Phe Leu Gln 
545                 550                 555                 560


Ser Leu Ser Asp Leu Ser Ile Thr Glu Gly Met Asp Glu Ala Phe Ala 
                565                 570                 575


Phe Arg Asp Asp Thr Ser Ala Ala Ser Ser Asp Ser Asp Ser Ala Ser 
            580                 585                 590


Tyr Ala Glu Ala Asp Asp Glu Arg Leu Tyr Ser Gly Glu Pro His Ala 
        595                 600                 605


Gln Ala Thr Leu Leu Gln Asp Ser Val Gln Lys Thr Glu Glu Glu Ser 
    610                 615                 620


Gly Gly Gly Ala Lys Gly Leu Gln Ala Gln Asp Gly Thr Val Ser Trp 
625                 630                 635                 640


Ala Val Glu Ala Ala Pro Gln Thr Ser Asp Arg Gly Ala Tyr Leu Ser 
                645                 650                 655


Gln Arg Gln Glu Leu Ile Ser Glu Val Thr Glu Glu Gly Leu Ala Leu 
            660                 665                 670


Gly Gln Glu Ser Thr Ala Thr Val Thr Pro His Thr Leu Gln Val Ala 
        675                 680                 685


Pro Gly Leu Gln Val Glu Val Ala Thr Arg Val Thr Pro Gln Ala Gly 
    690                 695                 700


Glu Glu Glu Thr Asp Ser Thr Ala Gly Gln Glu Ser Ala Ala Met Ala 
705                 710                 715                 720


Met Pro Gln Pro Ser Gln Glu Gly Ile Ser Glu Ile Leu Gly Gln Glu 
                725                 730                 735


Ser Val Thr Ala Glu Lys Leu Pro Thr Pro Gln Glu Glu Thr Ser Leu 
            740                 745                 750


Thr Leu Cys Pro Asp Ser Pro Gln Asn Leu Lys Glu Glu Gly Gly Leu 
        755                 760                 765


Asp Leu Pro Ser Gly Arg Lys Pro Val Ala Ala Ala Thr Ile Val Pro 
    770                 775                 780


Arg Gln Ala Lys Glu Asp Leu Thr Leu Pro Gln Asp Ser Ala Met Thr 
785                 790                 795                 800


Pro Pro Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro 
                805                 810                 815


Val Ala Ala Ala Thr Ile Val Ser Gln Gln Ala Glu Glu Gly Leu Thr 
            820                 825                 830


Leu Pro Gln Asp Ser Val Met Thr Pro Pro Leu Pro Leu Gln Asp Thr 
        835                 840                 845


Glu Leu Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr Leu Val Ser 
    850                 855                 860


Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr 
865                 870                 875                 880


Pro Pro Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro 
                885                 890                 895


Val Ala Ala Ala Thr Leu Val Ser Gln Gln Ala Glu Glu Gly Leu Thr 
            900                 905                 910


Leu Pro Gln Asp Ser Ala Met Thr Pro Pro Leu Pro Leu Gln Asp Thr 
        915                 920                 925


Asp Leu Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr Leu Val Ser 
    930                 935                 940


Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr 
945                 950                 955                 960


Pro Pro Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro 
                965                 970                 975


Val Ala Ala Ala Thr Ile Val Ser Gln Gln Ala Glu Glu Gly Leu Thr 
            980                 985                 990


Leu Pro Gln Asp Ser Ala Met Thr Pro Pro Leu Pro Leu Gln Asp Thr 
        995                 1000                1005


Asp Leu Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr Ile Val Ser 
    1010                1015                1020


Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr 
1025                1030                1035                1040


Pro Pro Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro 
                1045                1050                1055


Val Ala Ala Ala Thr Pro Val Ser Gln Gln Ala Glu Glu Gly Leu Thr 
            1060                1065                1070


Leu Pro Gln Asp Ser Ala Met Thr Pro Pro Leu Pro Leu Gln Asp Thr 
        1075                1080                1085


Asp Leu Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr Pro Val Ser 
    1090                1095                1100


Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr 
1105                1110                1115                1120


Ala Pro Leu Pro Leu Gln Asp Thr Gly Pro Thr Ser Gly Pro Glu Pro 
                1125                1130                1135


Leu Ala Val Ala Thr Pro Gln Thr Leu Gln Ala Glu Ala Gly Cys Ala 
            1140                1145                1150


Pro Gly Thr Glu Pro Val Ala Thr Met Ala Gln Gln Glu Val Gly Glu 
        1155                1160                1165


Ala Leu Gly Pro Arg Pro Ala Pro Glu Glu Lys Asn Ala Ala Leu Pro 
    1170                1175                1180


Thr Val Pro Glu Pro Ala Ala Leu Asp Gln Val Gln Gln Asp Asp Pro 
1185                1190                1195                1200


Gln Pro Ala Ala Glu Ala Gly Thr Pro Trp Ala Ala Gln Glu Asp Ala 
                1205                1210                1215


Asp Ser Thr Leu Gly Met Glu Ala Leu Ser Leu Pro Glu Pro Ala Ser 
            1220                1225                1230


Gly Ala Gly Glu Glu Ile Ala Glu Ala Leu Ser Arg Pro Gly Arg Glu 
        1235                1240                1245


Ala Cys Leu Glu Ala Arg Ala His Thr Gly Asp Gly Ala Lys Pro Asp 
    1250                1255                1260


Ser Pro Gln Lys Glu Thr Leu Glu Val Glu Asn Gln Gln Glu Gly Gly 
1265                1270                1275                1280


Leu Lys Pro Leu Ala Gln Glu His Gly Pro Arg Ser Ala Leu Gly Gly 
                1285                1290                1295


Ala Arg Glu Val Pro Asp Ala Pro Pro Ala Ala Cys Pro Glu Val Ser 
            1300                1305                1310


Gln Ala Arg Leu Leu Ser Pro Ala Arg Glu Glu Arg Gly Leu Ser Gly 
        1315                1320                1325


Lys Ser Thr Pro Glu Pro Thr Leu Pro Ser Ala Val Ala Thr Glu Ala 
    1330                1335                1340


Ser Leu Asp Ser Cys Pro Glu Ser Ser Val Gly Ala Val Ser Ser Leu 
1345                1350                1355                1360


Asp Arg Gly Cys Pro Asp Ala Pro Ala Pro Thr Ser Ala Pro Thr Ser 
                1365                1370                1375


Gln Gln Pro Glu Pro Val Leu Gly Leu Gly Ser Val Glu Gln Pro His 
            1380                1385                1390


Glu Val Pro Ser Val Leu Gly Thr Pro Leu Leu Gln Pro Pro Glu Asn 
        1395                1400                1405


Leu Ala Lys Gly Gln Pro Ser Thr Pro Val Asp Arg Pro Leu Gly Pro 
    1410                1415                1420


Asp Pro Ser Ala Pro Gly Thr Leu Ala Gly Ala Ala Leu Pro Pro Leu 
1425                1430                1435                1440


Glu Pro Pro Ala Pro Cys Leu Cys Gln Asp Pro Gln Glu Asp Ser Val 
                1445                1450                1455


Glu Asp Glu Glu Pro Pro Gly Ser Leu Gly Leu Pro Pro Pro Gln Ala 
            1460                1465                1470


Gly Val Gln Pro Ala Ala Ala Ala Val Ser Gly Thr Thr Gln Pro Leu 
        1475                1480                1485


Gly Thr Gly Pro Arg Val Ser Leu Ser Pro His Ser Pro Leu Leu Ser 
    1490                1495                1500


Pro Lys Val Ala Ser Met Asp Ala Lys Asp Leu Ala Leu Gln Ile Leu 
1505                1510                1515                1520


Pro Pro Cys Gln Val Pro Pro Pro Ser Gly Pro Gln Ser Pro Ala Gly 
                1525                1530                1535


Pro Gln Gly Leu Ser Ala Pro Glu Gln Gln Glu Asp Glu Asp Ser Leu 
            1540                1545                1550


Glu Glu Asp Ser Pro Arg Ala Leu Gly Ser Gly Gln His Ser Asp Ser 
        1555                1560                1565


His Gly Glu Ser Ser Ala Glu Leu Asp Glu Gln Asp Ile Leu Ala Pro 
    1570                1575                1580


Gln Thr Val Gln Cys Pro Ala Gln Ala Pro Ala Gly Gly Ser Glu Glu 
1585                1590                1595                1600


Thr Ile Ala Lys Ala Lys Gln Ser Arg Ser Glu Lys Lys Ala Arg Lys 
                1605                1610                1615


Ala Met Ser Lys Leu Gly Leu Arg Gln Ile Gln Gly Val Thr Arg Ile 
            1620                1625                1630


Thr Ile Gln Lys Ser Lys Asn Ile Leu Phe Val Ile Ala Lys Pro Asp 
        1635                1640                1645


Val Phe Lys Ser Pro Ala Ser Asp Thr Tyr Val Val Phe Gly Glu Ala 
    1650                1655                1660


Lys Ile Glu Asp Leu Ser Gln Gln Val His Lys Ala Ala Ala Glu Lys 
1665                1670                1675                1680


Phe Lys Val Pro Ser Glu Pro Ser Ala Leu Val Pro Glu Ser Ala Pro 
                1685                1690                1695


Arg Pro Arg Val Asp Glu Ala Gly Leu Glu Leu Arg Asp Ile Glu Leu 
            1700                1705                1710


Val Met Ala Gln Ala Asn Val Ser Arg Ala Lys Ala Val Arg Ala Leu 
        1715                1720                1725


Arg Asp Asn His Ser Asp Ile Val Asn Ala Ile Met Glu Leu Thr Met 
    1730                1735                1740


<210>  3760
<211>  493
<212>  DNA
<213>  Homo sapiens

<400>  3760
gatagccacg gggagtcatc agccgagctg gacgagcagg acatcttggc tcctcagacc     60

gtgcagtgtc cagcccaggc cccagcaggc ggcagtgagg agaccatcgc caaagccaag    120

cagacctgat gtcttcaaga gcccagcctc agacacttat gtggtctttg gcgaggccaa    180

gattgaggac ctgtcccagc aagtgcacaa agccgcagct gagaagttta aggtgccctc    240

agagccctca gccttggtcc ctgagtcagc acccaggccc cgggtggacg aggcggggct    300

ggaactgcgt gacattgagc tggtgatggc gcaggccaat gtgtccaggg ccaaggccgt    360

gcgggctctg agagacaacc acagtgacat cgtcaacgcc atcatggaac tgaccatgta    420

gccactgacc ggaagctgga gccatcctac gccttccctc agctctgcta ctcaataaat    480

cggtgtccct tca                                                       493


<210>  3761
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  3761

Met Ser Ser Arg Ala Gln Pro Gln Thr Leu Met Trp Ser Leu Ala Arg 
1               5                   10                  15


Pro Arg Leu Arg Thr Cys Pro Ser Lys Cys Thr Lys Pro Gln Leu Arg 
            20                  25                  30


Ser Leu Arg Cys Pro Gln Ser Pro Gln Pro Trp Ser Leu Ser Gln His 
        35                  40                  45


Pro Gly Pro Gly Trp Thr Arg Arg Gly Trp Asn Cys Val Thr Leu Ser 
    50                  55                  60


Trp 
65


<210>  3762
<211>  1255
<212>  DNA
<213>  Homo sapiens

<400>  3762
ggacagagcc tgtggccacc atggctcagc aggaagtagg tgaggcctta ggccccaggc     60

cagcacctga ggagaagaat gcagccctcc ctacagtccc ggagcctgca gccttggacc    120

aggtccaaca ggatgaccca cagccagctg cagaagctgg gacaccttgg gccgcacagg    180

aagatgcgga ttccactttg ggcatggagg ccctcagtct ccctgagccg gcctctggtg    240

ctggggagga aatagcagaa gccctttcta ggcctggacg ggaagcatgt ctggaagcgc    300

gagcgcacac aggtgatggg gctaagcctg actcacccca aaaggagacc ctggaggttg    360

agaaccagca ggaaggaggc ctgaagccac tggcacagga acatggaccc aggtcagcac    420

ttggaggtgc aagggaggtc cccgatgcgc ctcctgctgc ctgccctgag gtcagccagg    480

cccggctcct gagcccagcc agggaggaaa gaggcctgag tggcaagtcc accccggagc    540

ccacgcttcc ctcagctgtg gccacagagg ccagtctgga ctcctgccca gagtcttcag    600

taggggctgt gtccagtctg gacagaggct gccctgacgc gcctgccccc acgtctgcac    660

caacctccca gcagccggag cctgtactgg gtctgggcag tgttgagcaa ccccacgaag    720

tacccagtgt ccttggcacc cccttgctgc agcccccaga aaaccttgcc aagggtcagc    780

ccagcacgcc cgtggacagg cccctgggcc ctgacccttc tgctcctggt acccttgctg    840

gggcagccct acccccactg gagcccccag ccccctgcct gtgccaggac ccccaggaag    900

actctgtgga agacgaggag cccccaggct ctctgggcct cccaccgccc caggcaggag    960

tccagcctgc cgctgctgct gtctcaggaa ccacacagcc tctggggact gggccgcgag   1020

tcagcctctc gcctcactcc ccagggtgga cgaggcgggg ctggaactgc gtgacattga   1080

gctggtgatg gcgcaggcca atgtgtccag ggccaaggcc gtgcgggctc tgagagacaa   1140

ccacagtgac atcgtcaacg ccatcatgga actgaccatg tagccactga ccggaagctg   1200

gagccatcct acgccttccc tcagctctgc tactcaataa atcggtgtcc cttca        1255


<210>  3763
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  3763

Met Ala Gln Gln Glu Val Gly Glu Ala Leu Gly Pro Arg Pro Ala Pro 
1               5                   10                  15


Glu Glu Lys Asn Ala Ala Leu Pro Thr Val Pro Glu Pro Ala Ala Leu 
            20                  25                  30


Asp Gln Val Gln Gln Asp Asp Pro Gln Pro Ala Ala Glu Ala Gly Thr 
        35                  40                  45


Pro Trp Ala Ala Gln Glu Asp Ala Asp Ser Thr Leu Gly Met Glu Ala 
    50                  55                  60


Leu Ser Leu Pro Glu Pro Ala Ser Gly Ala Gly Glu Glu Ile Ala Glu 
65                  70                  75                  80


Ala Leu Ser Arg Pro Gly Arg Glu Ala Cys Leu Glu Ala Arg Ala His 
                85                  90                  95


Thr Gly Asp Gly Ala Lys Pro Asp Ser Pro Gln Lys Glu Thr Leu Glu 
            100                 105                 110


Val Glu Asn Gln Gln Glu Gly Gly Leu Lys Pro Leu Ala Gln Glu His 
        115                 120                 125


Gly Pro Arg Ser Ala Leu Gly Gly Ala Arg Glu Val Pro Asp Ala Pro 
    130                 135                 140


Pro Ala Ala Cys Pro Glu Val Ser Gln Ala Arg Leu Leu Ser Pro Ala 
145                 150                 155                 160


Arg Glu Glu Arg Gly Leu Ser Gly Lys Ser Thr Pro Glu Pro Thr Leu 
                165                 170                 175


Pro Ser Ala Val Ala Thr Glu Ala Ser Leu Asp Ser Cys Pro Glu Ser 
            180                 185                 190


Ser Val Gly Ala Val Ser Ser Leu Asp Arg Gly Cys Pro Asp Ala Pro 
        195                 200                 205


Ala Pro Thr Ser Ala Pro Thr Ser Gln Gln Pro Glu Pro Val Leu Gly 
    210                 215                 220


Leu Gly Ser Val Glu Gln Pro His Glu Val Pro Ser Val Leu Gly Thr 
225                 230                 235                 240


Pro Leu Leu Gln Pro Pro Glu Asn Leu Ala Lys Gly Gln Pro Ser Thr 
                245                 250                 255


Pro Val Asp Arg Pro Leu Gly Pro Asp Pro Ser Ala Pro Gly Thr Leu 
            260                 265                 270


Ala Gly Ala Ala Leu Pro Pro Leu Glu Pro Pro Ala Pro Cys Leu Cys 
        275                 280                 285


Gln Asp Pro Gln Glu Asp Ser Val Glu Asp Glu Glu Pro Pro Gly Ser 
    290                 295                 300


Leu Gly Leu Pro Pro Pro Gln Ala Gly Val Gln Pro Ala Ala Ala Ala 
305                 310                 315                 320


Val Ser Gly Thr Thr Gln Pro Leu Gly Thr Gly Pro Arg Val Ser Leu 
                325                 330                 335


Ser Pro His Ser Pro Gly Trp Thr Arg Arg Gly Trp Asn Cys Val Thr 
            340                 345                 350


Leu Ser Trp 
        355


<210>  3764
<211>  4653
<212>  DNA
<213>  Homo sapiens

<400>  3764
ggggaccggc gggagccctg tgctctgacc ccagggccca gccacctggc cctcacgttc     60

ctgcccagca agccgggtgc ccggccccag cccgagggag ccagctggga tgcagggcct    120

ggtggggcac cctcggcctg ggcggaccca ggggagggcg gcccaagccc catgctcctc    180

cctgagggcc tgtcttccca ggctctgtcc acggaggctc ctctcccggc caccctggag    240

ccccggattg tgatgggaga ggagacgtgc caggccctcc tgtcacccag agctgcccgg    300

acagcgctca gggaccagga gggtgggcac gcaagcccag acccaccccc cgagctgtgt    360

tctcagggtg atctttctgt gccttcccct cccccagacc ctgattcctt cttcacgcct    420

ccctccaccc ccaccaagac cacctatgcc ctgcttcctg cctgtgggcc ccacggggac    480

gccagggact cagaggctga gctgcgggat gagctgctgg actcgccccc cgcctcaccc    540

tcgggctcct acattacggc cgatggggac agctgggcct cttcaccctc ctgttccctc    600

agcctgctgg ctccggctga agggctggac ttcccctcag gctggggcct gtccccgcag    660

gggtccatgg tggatgaacg agagctgcac ccagcaggga ccccagagcc cccgtcctct    720

gagtccagcc tctctgcaga cagcagctcc tcctggggcc aggagggcca cttcttcgac    780

ctggacttcc tggccaatga cccaatgatc cccgcagccc tcctaccctt ccagggcagc    840

ctcatctttc aggtggaggc agtggaggtg acaccgctat ccccagagga agaagaagag    900

gaggctgtgg cggatcccga cccaggtggg gacctggctg gggagggtga ggaggacagc    960

acgtctgcct ccttcctgca gtcactgtct gacctgtcca tcacggaggg catggacgag   1020

gcttttgcct tccgggacga cacctctgca gcctcctctg attcagactc agcctcctac   1080

gcagaggcag atgatgagag gctgtacagc ggggagcccc atgcccaggc cactttgctc   1140

caggacagtg tccagaagac agaggaggag agcggaggtg gggccaaggg gctgcaggct   1200

caggatggga ctgtgtcctg ggccgtggag gctgctcctc agacctcaga cagaggggcc   1260

tatctgtccc agagacagga attgatctca gaagtaacag aagagggcct tgctttaggc   1320

caggagtcca ctgccactgt gacccctcac actctgcagg tagccccagg cctccaggtg   1380

gaggtggcta ccagagtgac cccacaggct ggggaggaag aaacagactc caccgctgga   1440

caagaatctg ctgccatggc aatgcctcag ccctcccagg agggcatcag cgagatctta   1500

ggccaagagt ctgtcactgc agaaaaactt ccaactccac aggaagaaac aagcctcaca   1560

ttgtgtccag actctcctca gaacttgaag gaagaaggag ggctggacct cccctctggc   1620

agaaagcctg tagctgcagc cacgattgtc cccaggcagg ctaaagagga cctcacctta   1680

ccccaggact ccgctatgac accgcctctg cccctacaag acacagatct ctcatcagcc   1740

ccaaagcctg tggctgcagc cacgattgtg tcccagcagg ctgaagaggg cctcacctta   1800

ccccaggact ccgttatgac accgcctctg cccctacaag acacagaact ctcgtcagcc   1860

ccaaagcctg tggctgcagc cacgcttgtg tcccagcagg ctgaagaggg cctcacctta   1920

ccccaggact ccgctatgac accgcctctg cccctacaag acacagatct ctcgtcagcc   1980

ccaaagcctg tggctgcagc cacgcttgtg tcccagcagg ctgaagaggg cctcacctta   2040

ccccaggact ccgctatgac accgcctctg cccctacaag acacagatct ctcgtcagcc   2100

ccaaagcctg tggctgcagc cacgcttgtg tcccagcagg ctgaagaggg cctcacctta   2160

ccccaggact ccgctatgac accgcctctg cccctacaag acacagatct ctcgtcagcc   2220

ccaaagcctg tggctgcagc cacgattgtg tcccagcagg ctgaagaggg cctcacctta   2280

ccccaggact ccgctatgac accgcctctg cccctacaag acacagatct ctcgtcagcc   2340

ccaaagcctg tggctgcagc cacgattgtg tcccagcagg ctgaagaggg cctcacctta   2400

ccccaggact ccgctatgac accgcctctg cccctacaag acacagatct ctcgtcagcc   2460

ccaaagcctg tggctgcagc cacgcctgtg tcccagcagg ctgaagaggg cctcacctta   2520

ccccaggact ccgctatgac accgcctctg cccctacaag acacagatct ctcgtcagcc   2580

ccaaagcctg tggctgcagc cacgcctgtg tcccagcagg ctgaagaggg cctcacctta   2640

ccccaggact ccgctatgac agcacctctg cctctgcaag acacaggccc cacctcaggt   2700

ccagagcctc tggctgtggc cacccctcaa accttgcagg cagaagcagg ctgtgcccca   2760

gggacagagc ctgtggccac catggctcag caggaagtag gtgaggcctt aggccccagg   2820

ccagcacctg aggagaagaa tgcagccctc cctacagtcc cggagcctgc agccttggac   2880

caggtccaac aggatgaccc acagccagct gcagaagctg ggacaccttg ggccgcacag   2940

gaagatgcgg attccacttt gggcatggag gccctcagtc tccctgagcc ggcctctggt   3000

gctggggagg aaatagcaga agccctttct aggcctggac gggaagcatg tctggaagcg   3060

cgagcgcaca caggtgatgg ggctaagcct gactcacccc aaaaggagac cctggaggtt   3120

gagaaccagc aggaaggagg cctgaagcca ctggcacagg aacatggacc caggtcagca   3180

cttggaggtg caagggaggt ccccgatgcg cctcctgctg cctgccctga ggtcagccag   3240

gcccggctcc tgagcccagc cagggaggaa agaggcctga gtggcaagtc caccccggag   3300

cccacgcttc cctcagctgt ggccacagag gccagtctgg actcctgccc agagtcttca   3360

gtaggggctg tgtccagtct ggacagaggc tgccctgacg cgcctgcccc cacgtctgca   3420

ccaacctccc agcagccgga gcctgtactg ggtctgggca gtgttgagca accccacgaa   3480

gtacccagtg tccttggcac ccccttgctg cagcccccag aaaaccttgc caagggtcag   3540

cccagcacgc ccgtggacag gcccctgggc cctgaccctt ctgctcctgg tacccttgct   3600

ggggcagccc tacccccact ggagccccca gccccctgcc tgtgccagga cccccaggaa   3660

gactctgtgg aagacgagga gcccccaggc tctctgggcc tcccaccgcc ccaggcagga   3720

gtccagcctg ccgctgctgc tgtctcagga accacacagc ctctggggac tgggccgcga   3780

gtcagcctct cgcctcactc cccactcctc agccccaagg tggcctccat ggatgccaaa   3840

gacctggcct tgcagatctt gccgccttgc caagtgcctc ctccctctgg gccccagagc   3900

ccagctggcc ctcaagggct ctcagccccc gagcagcaag aggatgagga cagcctggag   3960

gaagactcgc ctcgggccct gggctcgggc cagcattcgg atagccacgg ggagtcatca   4020

gccgagctgg acgagcagga catcttggct cctcagaccg tgcagtgtcc agcccaggcc   4080

ccagcaggcg gcagtgagga gaccatcgcc aaagccaagc agagtcgcag tgagaagaag   4140

gcccgaaagg caatgtcaaa gctgggcttg cggcagattc agggagtcac caggatcacc   4200

atccagaagt ccaagaacat cctctttgtc atcgccaagc ctgatgtctt caagagccca   4260

gcctcagaca cttatgtggt ctttggcgag gccaagattg aggacctgtc ccagcaagtg   4320

cacaaagccg cagctgagaa gtttaaggtg ccctcagagc cctcagcctt ggtccctgag   4380

tcagcaccca ggccccgggt gaggctggag tgcaaggaag aggaagagga ggaggaggaa   4440

gaggtggacg aggcggggct ggaactgcgt gacattgagc tggtgatggc gcaggccaat   4500

gtgtccaggg ccaaggccgt gcgggctctg agagacaacc acagtgacat cgtcaacgcc   4560

atcatggaac tgaccatgta gccactgacc ggaagctgga gccatcctac gccttccctc   4620

agctctgcta ctcaataaat cggtgtccct tca                                4653


<210>  3765
<211>  1469
<212>  PRT
<213>  Homo sapiens

<400>  3765

Met Leu Leu Pro Glu Gly Leu Ser Ser Gln Ala Leu Ser Thr Glu Ala 
1               5                   10                  15


Pro Leu Pro Ala Thr Leu Glu Pro Arg Ile Val Met Gly Glu Glu Thr 
            20                  25                  30


Cys Gln Ala Leu Leu Ser Pro Arg Ala Ala Arg Thr Ala Leu Arg Asp 
        35                  40                  45


Gln Glu Gly Gly His Ala Ser Pro Asp Pro Pro Pro Glu Leu Cys Ser 
    50                  55                  60


Gln Gly Asp Leu Ser Val Pro Ser Pro Pro Pro Asp Pro Asp Ser Phe 
65                  70                  75                  80


Phe Thr Pro Pro Ser Thr Pro Thr Lys Thr Thr Tyr Ala Leu Leu Pro 
                85                  90                  95


Ala Cys Gly Pro His Gly Asp Ala Arg Asp Ser Glu Ala Glu Leu Arg 
            100                 105                 110


Asp Glu Leu Leu Asp Ser Pro Pro Ala Ser Pro Ser Gly Ser Tyr Ile 
        115                 120                 125


Thr Ala Asp Gly Asp Ser Trp Ala Ser Ser Pro Ser Cys Ser Leu Ser 
    130                 135                 140


Leu Leu Ala Pro Ala Glu Gly Leu Asp Phe Pro Ser Gly Trp Gly Leu 
145                 150                 155                 160


Ser Pro Gln Gly Ser Met Val Asp Glu Arg Glu Leu His Pro Ala Gly 
                165                 170                 175


Thr Pro Glu Pro Pro Ser Ser Glu Ser Ser Leu Ser Ala Asp Ser Ser 
            180                 185                 190


Ser Ser Trp Gly Gln Glu Gly His Phe Phe Asp Leu Asp Phe Leu Ala 
        195                 200                 205


Asn Asp Pro Met Ile Pro Ala Ala Leu Leu Pro Phe Gln Gly Ser Leu 
    210                 215                 220


Ile Phe Gln Val Glu Ala Val Glu Val Thr Pro Leu Ser Pro Glu Glu 
225                 230                 235                 240


Glu Glu Glu Glu Ala Val Ala Asp Pro Asp Pro Gly Gly Asp Leu Ala 
                245                 250                 255


Gly Glu Gly Glu Glu Asp Ser Thr Ser Ala Ser Phe Leu Gln Ser Leu 
            260                 265                 270


Ser Asp Leu Ser Ile Thr Glu Gly Met Asp Glu Ala Phe Ala Phe Arg 
        275                 280                 285


Asp Asp Thr Ser Ala Ala Ser Ser Asp Ser Asp Ser Ala Ser Tyr Ala 
    290                 295                 300


Glu Ala Asp Asp Glu Arg Leu Tyr Ser Gly Glu Pro His Ala Gln Ala 
305                 310                 315                 320


Thr Leu Leu Gln Asp Ser Val Gln Lys Thr Glu Glu Glu Ser Gly Gly 
                325                 330                 335


Gly Ala Lys Gly Leu Gln Ala Gln Asp Gly Thr Val Ser Trp Ala Val 
            340                 345                 350


Glu Ala Ala Pro Gln Thr Ser Asp Arg Gly Ala Tyr Leu Ser Gln Arg 
        355                 360                 365


Gln Glu Leu Ile Ser Glu Val Thr Glu Glu Gly Leu Ala Leu Gly Gln 
    370                 375                 380


Glu Ser Thr Ala Thr Val Thr Pro His Thr Leu Gln Val Ala Pro Gly 
385                 390                 395                 400


Leu Gln Val Glu Val Ala Thr Arg Val Thr Pro Gln Ala Gly Glu Glu 
                405                 410                 415


Glu Thr Asp Ser Thr Ala Gly Gln Glu Ser Ala Ala Met Ala Met Pro 
            420                 425                 430


Gln Pro Ser Gln Glu Gly Ile Ser Glu Ile Leu Gly Gln Glu Ser Val 
        435                 440                 445


Thr Ala Glu Lys Leu Pro Thr Pro Gln Glu Glu Thr Ser Leu Thr Leu 
    450                 455                 460


Cys Pro Asp Ser Pro Gln Asn Leu Lys Glu Glu Gly Gly Leu Asp Leu 
465                 470                 475                 480


Pro Ser Gly Arg Lys Pro Val Ala Ala Ala Thr Ile Val Pro Arg Gln 
                485                 490                 495


Ala Lys Glu Asp Leu Thr Leu Pro Gln Asp Ser Ala Met Thr Pro Pro 
            500                 505                 510


Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro Val Ala 
        515                 520                 525


Ala Ala Thr Ile Val Ser Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro 
    530                 535                 540


Gln Asp Ser Val Met Thr Pro Pro Leu Pro Leu Gln Asp Thr Glu Leu 
545                 550                 555                 560


Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr Leu Val Ser Gln Gln 
                565                 570                 575


Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr Pro Pro 
            580                 585                 590


Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro Val Ala 
        595                 600                 605


Ala Ala Thr Leu Val Ser Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro 
    610                 615                 620


Gln Asp Ser Ala Met Thr Pro Pro Leu Pro Leu Gln Asp Thr Asp Leu 
625                 630                 635                 640


Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr Leu Val Ser Gln Gln 
                645                 650                 655


Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr Pro Pro 
            660                 665                 670


Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro Val Ala 
        675                 680                 685


Ala Ala Thr Ile Val Ser Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro 
    690                 695                 700


Gln Asp Ser Ala Met Thr Pro Pro Leu Pro Leu Gln Asp Thr Asp Leu 
705                 710                 715                 720


Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr Ile Val Ser Gln Gln 
                725                 730                 735


Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr Pro Pro 
            740                 745                 750


Leu Pro Leu Gln Asp Thr Asp Leu Ser Ser Ala Pro Lys Pro Val Ala 
        755                 760                 765


Ala Ala Thr Pro Val Ser Gln Gln Ala Glu Glu Gly Leu Thr Leu Pro 
    770                 775                 780


Gln Asp Ser Ala Met Thr Pro Pro Leu Pro Leu Gln Asp Thr Asp Leu 
785                 790                 795                 800


Ser Ser Ala Pro Lys Pro Val Ala Ala Ala Thr Pro Val Ser Gln Gln 
                805                 810                 815


Ala Glu Glu Gly Leu Thr Leu Pro Gln Asp Ser Ala Met Thr Ala Pro 
            820                 825                 830


Leu Pro Leu Gln Asp Thr Gly Pro Thr Ser Gly Pro Glu Pro Leu Ala 
        835                 840                 845


Val Ala Thr Pro Gln Thr Leu Gln Ala Glu Ala Gly Cys Ala Pro Gly 
    850                 855                 860


Thr Glu Pro Val Ala Thr Met Ala Gln Gln Glu Val Gly Glu Ala Leu 
865                 870                 875                 880


Gly Pro Arg Pro Ala Pro Glu Glu Lys Asn Ala Ala Leu Pro Thr Val 
                885                 890                 895


Pro Glu Pro Ala Ala Leu Asp Gln Val Gln Gln Asp Asp Pro Gln Pro 
            900                 905                 910


Ala Ala Glu Ala Gly Thr Pro Trp Ala Ala Gln Glu Asp Ala Asp Ser 
        915                 920                 925


Thr Leu Gly Met Glu Ala Leu Ser Leu Pro Glu Pro Ala Ser Gly Ala 
    930                 935                 940


Gly Glu Glu Ile Ala Glu Ala Leu Ser Arg Pro Gly Arg Glu Ala Cys 
945                 950                 955                 960


Leu Glu Ala Arg Ala His Thr Gly Asp Gly Ala Lys Pro Asp Ser Pro 
                965                 970                 975


Gln Lys Glu Thr Leu Glu Val Glu Asn Gln Gln Glu Gly Gly Leu Lys 
            980                 985                 990


Pro Leu Ala Gln Glu His Gly Pro Arg Ser Ala Leu Gly Gly Ala Arg 
        995                 1000                1005


Glu Val Pro Asp Ala Pro Pro Ala Ala Cys Pro Glu Val Ser Gln Ala 
    1010                1015                1020


Arg Leu Leu Ser Pro Ala Arg Glu Glu Arg Gly Leu Ser Gly Lys Ser 
1025                1030                1035                1040


Thr Pro Glu Pro Thr Leu Pro Ser Ala Val Ala Thr Glu Ala Ser Leu 
                1045                1050                1055


Asp Ser Cys Pro Glu Ser Ser Val Gly Ala Val Ser Ser Leu Asp Arg 
            1060                1065                1070


Gly Cys Pro Asp Ala Pro Ala Pro Thr Ser Ala Pro Thr Ser Gln Gln 
        1075                1080                1085


Pro Glu Pro Val Leu Gly Leu Gly Ser Val Glu Gln Pro His Glu Val 
    1090                1095                1100


Pro Ser Val Leu Gly Thr Pro Leu Leu Gln Pro Pro Glu Asn Leu Ala 
1105                1110                1115                1120


Lys Gly Gln Pro Ser Thr Pro Val Asp Arg Pro Leu Gly Pro Asp Pro 
                1125                1130                1135


Ser Ala Pro Gly Thr Leu Ala Gly Ala Ala Leu Pro Pro Leu Glu Pro 
            1140                1145                1150


Pro Ala Pro Cys Leu Cys Gln Asp Pro Gln Glu Asp Ser Val Glu Asp 
        1155                1160                1165


Glu Glu Pro Pro Gly Ser Leu Gly Leu Pro Pro Pro Gln Ala Gly Val 
    1170                1175                1180


Gln Pro Ala Ala Ala Ala Val Ser Gly Thr Thr Gln Pro Leu Gly Thr 
1185                1190                1195                1200


Gly Pro Arg Val Ser Leu Ser Pro His Ser Pro Leu Leu Ser Pro Lys 
                1205                1210                1215


Val Ala Ser Met Asp Ala Lys Asp Leu Ala Leu Gln Ile Leu Pro Pro 
            1220                1225                1230


Cys Gln Val Pro Pro Pro Ser Gly Pro Gln Ser Pro Ala Gly Pro Gln 
        1235                1240                1245


Gly Leu Ser Ala Pro Glu Gln Gln Glu Asp Glu Asp Ser Leu Glu Glu 
    1250                1255                1260


Asp Ser Pro Arg Ala Leu Gly Ser Gly Gln His Ser Asp Ser His Gly 
1265                1270                1275                1280


Glu Ser Ser Ala Glu Leu Asp Glu Gln Asp Ile Leu Ala Pro Gln Thr 
                1285                1290                1295


Val Gln Cys Pro Ala Gln Ala Pro Ala Gly Gly Ser Glu Glu Thr Ile 
            1300                1305                1310


Ala Lys Ala Lys Gln Ser Arg Ser Glu Lys Lys Ala Arg Lys Ala Met 
        1315                1320                1325


Ser Lys Leu Gly Leu Arg Gln Ile Gln Gly Val Thr Arg Ile Thr Ile 
    1330                1335                1340


Gln Lys Ser Lys Asn Ile Leu Phe Val Ile Ala Lys Pro Asp Val Phe 
1345                1350                1355                1360


Lys Ser Pro Ala Ser Asp Thr Tyr Val Val Phe Gly Glu Ala Lys Ile 
                1365                1370                1375


Glu Asp Leu Ser Gln Gln Val His Lys Ala Ala Ala Glu Lys Phe Lys 
            1380                1385                1390


Val Pro Ser Glu Pro Ser Ala Leu Val Pro Glu Ser Ala Pro Arg Pro 
        1395                1400                1405


Arg Val Arg Leu Glu Cys Lys Glu Glu Glu Glu Glu Glu Glu Glu Glu 
    1410                1415                1420


Val Asp Glu Ala Gly Leu Glu Leu Arg Asp Ile Glu Leu Val Met Ala 
1425                1430                1435                1440


Gln Ala Asn Val Ser Arg Ala Lys Ala Val Arg Ala Leu Arg Asp Asn 
                1445                1450                1455


His Ser Asp Ile Val Asn Ala Ile Met Glu Leu Thr Met 
            1460                1465


<210>  3766
<211>  1435
<212>  DNA
<213>  Homo sapiens

<400>  3766
cctttctagg cctggacggg aagcatgtct ggaagcgcga gcgcacacag gtgatggggc     60

taagcctgac tcaccccaaa aggagaccct ggaggttgag aaccagcagg aaggaggcct    120

gaagccactg gcacaggaac atggacccag gtcagcactt ggaggtgcaa gggaggtccc    180

cgatgcgcct cctgctgcct gccctgaggt cagccaggcc cggctcctga gcccagccag    240

ggaggaaaga ggcctgagtg gcaagtccac cccggagccc acgcttccct cagctgtggc    300

cacagaggcc agtctggact cctgcccaga gtcttcagta ggggctgtgt ccagtctgga    360

cagaggctgc cctgacgcgc ctgcccccac gtctgcacca acctcccagc agccggagcc    420

tgtactgggt ctgggcagtg ttgagcaacc ccacgaagta cccagtgtcc ttggcacccc    480

cttgctgcag cccccagaaa accttgccaa gggtcagccc agcacgcccg tggacaggcc    540

cctgggccct gacccttctg ctcctggtac ccttgctggg gcagccctac ccccactgga    600

gcccccagcc ccctgcctgt gccaggaccc ccaggaagac tctgtggaag acgaggagcc    660

cccaggctct ctgggcctcc caccgcccca ggcaggagtc cagcctgccg ctgctgctgt    720

ctcaggaacc acacagcctc tggggactgg gccgcgagtc agcctctcgc ctcactcccc    780

actcctcagc cccaaggtgg cctccatgga tgccaaagac ctggccttgc agatcttgcc    840

gccttgccaa gtgcctcctc cctctgggcc ccagagccca gctggccctc aagggctctc    900

agcccccgag cagcaagagg atgaggacag cctggaggaa gactcgcctc gggccctggg    960

ctcgggccag cattcggata gccacgggga gtcatcagcc gagctggacg agcaggacat   1020

cttggctcct cagaccgtgc agtgtccagc ccaggcccca gcaggcggca gtgaggagac   1080

catcgccaaa gccaagcaga gtcgcagtga gaagaaggcc cgaaaggcaa tgtcaaagct   1140

gggcttgcgg cagattcagg gagtcaccag gatcaccatc cagaagtcca agaacatcct   1200

ctttgtcatc gccaagcctg atgtcttcaa gagcccagcc tcagacactt atgtggtctt   1260

tggcgaggcc aagattgagg acctgtccca gcaagtgcac aaagccgcag ctgagaaaca   1320

accacagtga catcgtcaac gccatcatgg aactgaccat gtagccactg accggaagct   1380

ggagccatcc tacgccttcc ctcagctctg ctactcaata aatcggtgtc ccttc        1435


<210>  3767
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  3767

Met Pro Lys Thr Trp Pro Cys Arg Ser Cys Arg Leu Ala Lys Cys Leu 
1               5                   10                  15


Leu Pro Leu Gly Pro Arg Ala Gln Leu Ala Leu Lys Gly Ser Gln Pro 
            20                  25                  30


Pro Ser Ser Lys Arg Met Arg Thr Ala Trp Arg Lys Thr Arg Leu Gly 
        35                  40                  45


Pro Trp Ala Arg Ala Ser Ile Arg Ile Ala Thr Gly Ser His Gln Pro 
    50                  55                  60


Ser Trp Thr Ser Arg Thr Ser Trp Leu Leu Arg Pro Cys Ser Val Gln 
65                  70                  75                  80


Pro Arg Pro Gln Gln Ala Ala Val Arg Arg Pro Ser Pro Lys Pro Ser 
                85                  90                  95


Arg Val Ala Val Arg Arg Arg Pro Glu Arg Gln Cys Gln Ser Trp Ala 
            100                 105                 110


Cys Gly Arg Phe Arg Glu Ser Pro Gly Ser Pro Ser Arg Ser Pro Arg 
        115                 120                 125


Thr Ser Ser Leu Ser Ser Pro Ser Leu Met Ser Ser Arg Ala Gln Pro 
    130                 135                 140


Gln Thr Leu Met Trp Ser Leu Ala Arg Pro Arg Leu Arg Thr Cys Pro 
145                 150                 155                 160


Ser Lys Cys Thr Lys Pro Gln Leu Arg Asn Asn His Ser Asp Ile Val 
                165                 170                 175


Asn Ala Ile Met Glu Leu Thr Met 
            180


<210>  3768
<211>  1891
<212>  DNA
<213>  Homo sapiens

<400>  3768
ggacagagcc tgtggccacc atggctcagc aggaagtagg tgaggcctta ggccccaggc     60

cagcacctga ggagaagaat gcagccctcc ctacagtccc ggagcctgca gccttggacc    120

aggtccaaca ggatgaccca cagccagctg cagaagctgg gacaccttgg gccgcacagg    180

aagatgcgga ttccactttg ggcatggagg ccctcagtct ccctgagccg gcctctggtg    240

ctggggagga aatagcagaa gccctttcta ggcctggacg ggaagcatgt ctggaagcgc    300

gagcgcacac aggtgatggg gctaagcctg actcacccca aaaggagacc ctggaggttg    360

agaaccagca ggaaggaggc ctgaagccac tggcacagga acatggaccc aggtcagcac    420

ttggaggtgc aagggaggtc cccgatgcgc ctcctgctgc ctgccctgag gtcagccagg    480

cccggctcct gagcccagcc agggaggaaa gaggcctgag tggcaagtcc accccggagc    540

ccacgcttcc ctcagctgtg gccacagagg ccagtctgga ctcctgccca gagtcttcag    600

taggggctgt gtccagtctg gacagaggct gccctgacgc gcctgccccc acgtctgcac    660

caacctccca gcagccggag cctgtactgg gtctgggcag tgttgagcaa ccccacgaag    720

tacccagtgt ccttggcacc cccttgctgc agcccccaga aaaccttgcc aagggtcagc    780

ccagcacgcc cgtggacagg cccctgggcc ctgacccttc tgctcctggt acccttgctg    840

gggcagccct acccccactg gagcccccag ccccctgcct gtgccaggac ccccaggaag    900

actctgtgga agacgaggag cccccaggct ctctgggcct cccaccgccc caggcaggag    960

tccagcctgc cgctgctgct gtctcaggaa ccacacagcc tctggggact gggccgcgag   1020

tcagcctctc gcctcactcc ccactcctca gccccaaggt ggcctccatg gatgccaaag   1080

acctggcctt gcagatcttg ccgccttgcc aagtgcctcc tccctctggg ccccagagcc   1140

cagctggccc tcaagggctc tcagcccccg agcagcaaga ggatgaggac agcctggagg   1200

aagactcgcc tcgggccctg ggctcgggcc agcattcgga tagccacggg gagtcatcag   1260

ccgagctgga cgagcaggac atcttggctc ctcagaccgt gcagtgtcca gcccaggccc   1320

cagcaggcgg cagtgaggag accatcgcca aagccaagca gagtcgcagt gagaagaagg   1380

cccgaaaggc aatgtcaaag ctgggcttgc ggcagattca gggagtcacc aggatcacca   1440

tccagaagtc caagaacatc ctctttgtca tcgccaagcc tgatgtcttc aagagcccag   1500

cctcagacac ttatgtggtc tttggcgagg ccaagattga ggacctgtcc cagcaagtgc   1560

acaaagccgc agctgagaag tttaaggtgc cctcagagcc ctcagccttg gtccctgagt   1620

cagcacccag gccccgggtg aggctggagt gcaaggaaga ggaagaggag gaggaggaag   1680

aggtggacga ggcggggctg gaactgcgtg acattgagct ggtgatggcg caggccaatg   1740

tgtccagggc caaggccgtg cgggctctga gagacaacca cagtgacatc gtcaacgcca   1800

tcatggaact gaccatgtag ccactgaccg gaagctggag ccatcctacg ccttccctca   1860

gctctgctac tcaataaatc ggtgtccctt c                                  1891


<210>  3769
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  3769

Met Ala Gln Gln Glu Val Gly Glu Ala Leu Gly Pro Arg Pro Ala Pro 
1               5                   10                  15


Glu Glu Lys Asn Ala Ala Leu Pro Thr Val Pro Glu Pro Ala Ala Leu 
            20                  25                  30


Asp Gln Val Gln Gln Asp Asp Pro Gln Pro Ala Ala Glu Ala Gly Thr 
        35                  40                  45


Pro Trp Ala Ala Gln Glu Asp Ala Asp Ser Thr Leu Gly Met Glu Ala 
    50                  55                  60


Leu Ser Leu Pro Glu Pro Ala Ser Gly Ala Gly Glu Glu Ile Ala Glu 
65                  70                  75                  80


Ala Leu Ser Arg Pro Gly Arg Glu Ala Cys Leu Glu Ala Arg Ala His 
                85                  90                  95


Thr Gly Asp Gly Ala Lys Pro Asp Ser Pro Gln Lys Glu Thr Leu Glu 
            100                 105                 110


Val Glu Asn Gln Gln Glu Gly Gly Leu Lys Pro Leu Ala Gln Glu His 
        115                 120                 125


Gly Pro Arg Ser Ala Leu Gly Gly Ala Arg Glu Val Pro Asp Ala Pro 
    130                 135                 140


Pro Ala Ala Cys Pro Glu Val Ser Gln Ala Arg Leu Leu Ser Pro Ala 
145                 150                 155                 160


Arg Glu Glu Arg Gly Leu Ser Gly Lys Ser Thr Pro Glu Pro Thr Leu 
                165                 170                 175


Pro Ser Ala Val Ala Thr Glu Ala Ser Leu Asp Ser Cys Pro Glu Ser 
            180                 185                 190


Ser Val Gly Ala Val Ser Ser Leu Asp Arg Gly Cys Pro Asp Ala Pro 
        195                 200                 205


Ala Pro Thr Ser Ala Pro Thr Ser Gln Gln Pro Glu Pro Val Leu Gly 
    210                 215                 220


Leu Gly Ser Val Glu Gln Pro His Glu Val Pro Ser Val Leu Gly Thr 
225                 230                 235                 240


Pro Leu Leu Gln Pro Pro Glu Asn Leu Ala Lys Gly Gln Pro Ser Thr 
                245                 250                 255


Pro Val Asp Arg Pro Leu Gly Pro Asp Pro Ser Ala Pro Gly Thr Leu 
            260                 265                 270


Ala Gly Ala Ala Leu Pro Pro Leu Glu Pro Pro Ala Pro Cys Leu Cys 
        275                 280                 285


Gln Asp Pro Gln Glu Asp Ser Val Glu Asp Glu Glu Pro Pro Gly Ser 
    290                 295                 300


Leu Gly Leu Pro Pro Pro Gln Ala Gly Val Gln Pro Ala Ala Ala Ala 
305                 310                 315                 320


Val Ser Gly Thr Thr Gln Pro Leu Gly Thr Gly Pro Arg Val Ser Leu 
                325                 330                 335


Ser Pro His Ser Pro Leu Leu Ser Pro Lys Val Ala Ser Met Asp Ala 
            340                 345                 350


Lys Asp Leu Ala Leu Gln Ile Leu Pro Pro Cys Gln Val Pro Pro Pro 
        355                 360                 365


Ser Gly Pro Gln Ser Pro Ala Gly Pro Gln Gly Leu Ser Ala Pro Glu 
    370                 375                 380


Gln Gln Glu Asp Glu Asp Ser Leu Glu Glu Asp Ser Pro Arg Ala Leu 
385                 390                 395                 400


Gly Ser Gly Gln His Ser Asp Ser His Gly Glu Ser Ser Ala Glu Leu 
                405                 410                 415


Asp Glu Gln Asp Ile Leu Ala Pro Gln Thr Val Gln Cys Pro Ala Gln 
            420                 425                 430


Ala Pro Ala Gly Gly Ser Glu Glu Thr Ile Ala Lys Ala Lys Gln Ser 
        435                 440                 445


Arg Ser Glu Lys Lys Ala Arg Lys Ala Met Ser Lys Leu Gly Leu Arg 
    450                 455                 460


Gln Ile Gln Gly Val Thr Arg Ile Thr Ile Gln Lys Ser Lys Asn Ile 
465                 470                 475                 480


Leu Phe Val Ile Ala Lys Pro Asp Val Phe Lys Ser Pro Ala Ser Asp 
                485                 490                 495


Thr Tyr Val Val Phe Gly Glu Ala Lys Ile Glu Asp Leu Ser Gln Gln 
            500                 505                 510


Val His Lys Ala Ala Ala Glu Lys Phe Lys Val Pro Ser Glu Pro Ser 
        515                 520                 525


Ala Leu Val Pro Glu Ser Ala Pro Arg Pro Arg Val Arg Leu Glu Cys 
    530                 535                 540


Lys Glu Glu Glu Glu Glu Glu Glu Glu Glu Val Asp Glu Ala Gly Leu 
545                 550                 555                 560


Glu Leu Arg Asp Ile Glu Leu Val Met Ala Gln Ala Asn Val Ser Arg 
                565                 570                 575


Ala Lys Ala Val Arg Ala Leu Arg Asp Asn His Ser Asp Ile Val Asn 
            580                 585                 590


Ala Ile Met Glu Leu Thr Met 
        595


<210>  3770
<211>  328
<212>  DNA
<213>  Homo sapiens

<400>  3770
ggggaaggac caaccaccag cccaaggtct tggggaagtt ggcggtggag actttgcctt     60

cctgggcact gtgctgctct cctcccccga cgtgggtcaa caccaggtct gagcccccct    120

ctgccctcta ctcccaggca atgtcaaagc tgggcttgcg gcagattcag ggagtcacca    180

ggatcaccat ccagaagtcc aagaacatcc tctttgtcat cgccaagcct gatgtcttca    240

agagcccagc ctcagacact tatgtggtct ttggcgaggc caagattgag gacctgtccc    300

agcaagtgca caaagccgca gctgagaa                                       328


<210>  3771
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  3771

Met Ser Lys Leu Gly Leu Arg Gln Ile Gln Gly Val Thr Arg Ile Thr 
1               5                   10                  15


Ile Gln Lys Ser Lys Asn Ile Leu Phe Val Ile Ala Lys Pro Asp Val 
            20                  25                  30


Phe Lys Ser Pro Ala Ser Asp Thr Tyr Val Val Phe Gly Glu Ala Lys 
        35                  40                  45


Ile Glu Asp Leu Ser Gln Gln Val His Lys Ala Ala Ala 
    50                  55                  60


<210>  3772
<211>  4461
<212>  DNA
<213>  Homo sapiens

<400>  3772
tcgtttccgc cggcgctccg agtgacgtag ggaagcgcgc cgcgcacctc atggttccgg     60

ggacagttag ggcggcggat ggaggtcagc ggtggtgctc gctgcggttt ggaatcactt    120

gctaggagtc ttgtctctct gccacccagg acatcatggc agctcacctg gtaaagcgat    180

gcacgtgcct cctgagagaa gctgctcgtc aggcccctgc catggctcca gttggccgac    240

tgagacttgc ctgggtagcc cataagactc tgacttcctc agccacctca cccatttccc    300

acctcccagg ttccttgatg gagccggtgg agaaggaacg agcatctact ccctacatag    360

agaagcaggt ggaccacctc atcaagaagg ccacaaggcc agaggagctc ctggagctac    420

ttggtggcag tcacgacttg gacagcaatc aagcagcaat ggtacttatc cggctctctc    480

acttgctgtc tgagaagcca gaagataaag gcttgctcat acaggatgcc cactttcatc    540

aacttctctg tctgctcaac agtcagattg cctcggtctg gcatggtacc ctctcgaagc    600

tgctgggaag cctgtatgct ctgggcatcc ccaaggcctc caaggagctg cagtcggtgg    660

agcaggaggt ccgctggcgc atgcggaagc tcaagtacaa gcacctggcc ttcctggcag    720

agtcctgtgc caccctctca caggagcagc actcgcagga gctgctggct gagctgctca    780

cacacctgga aaggcgttgg acagaaattg aagattccca cacattagtg accgtcatga    840

tgaaggtggg acacctctcg gagccactaa tgaaccgcct ggaagacaag cacgtcctga    900

acagagcgca ggacatcacc ctgccccacc tgtgcagcgt acttctggct tttgcgcgtc    960

tgaacttcca tccagaccaa gaggatcagt tcttcagcct ggtacatgag aagctggggt   1020

cagagctgcc aggcctggag ccagccctgc aggtggacct ggtgtgggcc ctgtgtgtgc   1080

tgcagcaggc acgggaagca gagctgcaag ccgtcctcca ccctgaattt cacatccaat   1140

ttctaggggg caagtctcag aaggatcaga acaccttcca gaagctgctc cacatcaacg   1200

ccactgccct gctggagtac cccgagtact cgggtcccct tctgcctgcc tcggctgtgg   1260

cccctgggcc ctcagccctt gacaggaagg tgacccccct gcaaaaggag ctgcaggaga   1320

cgctgaaggg gctgctgggg agcgccgaca agggcagcct cgaggtggcc acgcagtatg   1380

gctgggtgct ggatgctgag gtgctgctgg acagtgacgg cgagtttctg cccgtaaggg   1440

actttgtggc acctcacctt gcccagccaa ctgggagcca gtcaccacct ccagggtcta   1500

agaggctagc gttcttgcgg tgggagttcc ccaacttcaa cagccgaagc aaggacttgc   1560

tgggtcgctt tgttctggcc cggcgacaca tagtggctgc aggcttcctg atagtggacg   1620

tcccattcta tgagtggctg gaactcaagt ctgaatggca gaaaggcgcc tacctcaagg   1680

acaagatgcg caaagcggtg gctgaggagc tggccaagtg acttgtgcca gcagcatgga   1740

ctgcgtgcct ctccgccgga ggtctagctg tgggcggcca agaagggtca cccttgagga   1800

caaacctctg tgcaggacct tggccagagt ggggagggtg gccagccact ctgagggaca   1860

gaacgtcctc ttgtgtataa taaaccttta attttggtgt tggacccctg gggccttccc   1920

aggcttggtc accctctgca ctgtcagcac ttgtctgtct gctttgttga gcagggcgtg   1980

gttctccagt ctgccctgtg cactcccccg ccacgcccag cccaagaggg ctgctttagg   2040

gacagacctg ggttgttacc tgcctgtctc tcccagcttc ttccctccat gagtgcttat   2100

tcacatatgc cggcctcttg cgtaggggtc tgtatcagcc ccagcaggca ggtggagtcc   2160

tagaattctg aacctccaga gcagaggagc ttcccaggga agctgattgg agattcagtg   2220

catggctggg ggttctgatg gagctgtggc tactgaacca cagccatcct gggaggcttt   2280

ctcccatcag ttgtctcaca cttagctgag tgaaaggcac cctgacagca tgtggtgaca   2340

ggtgatgtga gggctgggtg agcacttggg aggcgctggc tctgggagag gagaagatcc   2400

cacttggctg acaccacggc accaagagcc aaactccatc gttgtcttca ccaccctgac   2460

cagagccttg tgctgtcatc taggaactgg ctgcccaaac aggaccctgg cagcctccct   2520

gctgctgcgg ggattaccag gtgctgggag gcaacaagct ttctaccttc cagcctctcc   2580

ttagagacac ctattggcag aacctgacta aatagcagtc agggaactgg gttgcctcca   2640

gccatacaga acagagagta ggacagtggg gtggagctga gatggagagg cccacagccc   2700

tcagcactgt aggctcccaa ccctaggctg tttccccaaa aagaaaaagt ctagtcactg   2760

ctctgatgct tggccactca cccaagcatt ggggtagttt gtgctggctt cactgggcac   2820

catcaggcac acccagcctg tagtttttgt tttatattac ctaagtcggc caggtgtggt   2880

gggatcacgc ctgtaatccc agcacttagg gaggctgggg cgggcgaatc gcctgaggcc   2940

aggaattcaa gaccaacctg gccaacattg tgaaaccctg tctctactaa aaatataaaa   3000

attagtcggg catgatgaca ggcacctgta atcccagcta ctcaggaggc tgaggcaggt   3060

gaatcacttg aacccgggag gtggaggctg cagtgagtta agattgtgcc actgcactcc   3120

agcctgggta acagagcaag actctgtctc aaaaaatata tatgtgtgtg tgtgtgtgtg   3180

tatatatatg tacatgtgta tataagtata tatgtgtgta tatatgtata tatacacgta   3240

tatacacaca cacccctaag tcatgatttt ggagcaattg taagtggtgt agtgcttaat   3300

tttggcattc acacattgat tgttagcata tagaaatggg attgattttt atgtgatctt   3360

gctaaacttt atgcattttt aaaattcctt tggatttcct atgtagatat ttatgtcctg   3420

aaaacaggaa tgtatttatc ctttcaaatc aatatgcttt ttattttgtt atttatgacc   3480

acttcattaa aatataattc acatgccata cacttcaccc atttaaaatg tataattagg   3540

ccaggtgtgg tggctcacgt ctgtaatccc agcagtttgg gaggccaagg ccctcagatc   3600

ttgagcccag gagttcaaga ccaccctggg caacaggcaa aaccctgtct ctatttttta   3660

aaatacaaga attagccgca gtggcacgca cctgtcgtcc cagcaaccca ggaggctgag   3720

gtaggaggat cacttaagcc tgggaagtca agcctgcagt gaaccatgat agcaccactg   3780

cagtccagcc tgggcgacag agtgagaccc catctcgaaa acaaaaatgt ataattcagt   3840

ggtttttagt ctctttgcag atacatgcaa ccatcaccac aatttgcaca ttttctaagc   3900

ctcatatact gatgtgatat tttggtgttt tgtgactggc ttcatttact tagcatattg   3960

ttttcatgtt tcattcatgt cgcatgtatg agtattcatt cctttatttg gctgaataat   4020

attccattat agtttgtgcc acattttgtt tatccattca tccattgatg gacatgtgga   4080

ttgtttccac cttctggata atatgaactg atacagtttg gatattttgt cccctccaaa   4140

tctcatgaaa taggatcacc agtgttggag aatggggcct gttaggaagt gtttggatca   4200

taggaacatc tgtcataaat ggcttggtgc catccttgta atgagtgagt tcttgctcta   4260

tattagttca cttgaaagct ggttgttggg aactcctgcc ctatctgttc tgccctctct   4320

cgtcatgtga catgcctgct ccttgttcac cttctgtcat gagtaaaagc ttcctaaggc   4380

cttcccagga gccaagcaga tgtcagtacc atgcttgtac agcctgcaga actgtgagcc   4440

aaataaactt ctttataaat t                                             4461


<210>  3773
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  3773

Met Ala Ala His Leu Val Lys Arg Cys Thr Cys Leu Leu Arg Glu Ala 
1               5                   10                  15


Ala Arg Gln Ala Pro Ala Met Ala Pro Val Gly Arg Leu Arg Leu Ala 
            20                  25                  30


Trp Val Ala His Lys Thr Leu Thr Ser Ser Ala Thr Ser Pro Ile Ser 
        35                  40                  45


His Leu Pro Gly Ser Leu Met Glu Pro Val Glu Lys Glu Arg Ala Ser 
    50                  55                  60


Thr Pro Tyr Ile Glu Lys Gln Val Asp His Leu Ile Lys Lys Ala Thr 
65                  70                  75                  80


Arg Pro Glu Glu Leu Leu Glu Leu Leu Gly Gly Ser His Asp Leu Asp 
                85                  90                  95


Ser Asn Gln Ala Ala Met Val Leu Ile Arg Leu Ser His Leu Leu Ser 
            100                 105                 110


Glu Lys Pro Glu Asp Lys Gly Leu Leu Ile Gln Asp Ala His Phe His 
        115                 120                 125


Gln Leu Leu Cys Leu Leu Asn Ser Gln Ile Ala Ser Val Trp His Gly 
    130                 135                 140


Thr Leu Ser Lys Leu Leu Gly Ser Leu Tyr Ala Leu Gly Ile Pro Lys 
145                 150                 155                 160


Ala Ser Lys Glu Leu Gln Ser Val Glu Gln Glu Val Arg Trp Arg Met 
                165                 170                 175


Arg Lys Leu Lys Tyr Lys His Leu Ala Phe Leu Ala Glu Ser Cys Ala 
            180                 185                 190


Thr Leu Ser Gln Glu Gln His Ser Gln Glu Leu Leu Ala Glu Leu Leu 
        195                 200                 205


Thr His Leu Glu Arg Arg Trp Thr Glu Ile Glu Asp Ser His Thr Leu 
    210                 215                 220


Val Thr Val Met Met Lys Val Gly His Leu Ser Glu Pro Leu Met Asn 
225                 230                 235                 240


Arg Leu Glu Asp Lys His Val Leu Asn Arg Ala Gln Asp Ile Thr Leu 
                245                 250                 255


Pro His Leu Cys Ser Val Leu Leu Ala Phe Ala Arg Leu Asn Phe His 
            260                 265                 270


Pro Asp Gln Glu Asp Gln Phe Phe Ser Leu Val His Glu Lys Leu Gly 
        275                 280                 285


Ser Glu Leu Pro Gly Leu Glu Pro Ala Leu Gln Val Asp Leu Val Trp 
    290                 295                 300


Ala Leu Cys Val Leu Gln Gln Ala Arg Glu Ala Glu Leu Gln Ala Val 
305                 310                 315                 320


Leu His Pro Glu Phe His Ile Gln Phe Leu Gly Gly Lys Ser Gln Lys 
                325                 330                 335


Asp Gln Asn Thr Phe Gln Lys Leu Leu His Ile Asn Ala Thr Ala Leu 
            340                 345                 350


Leu Glu Tyr Pro Glu Tyr Ser Gly Pro Leu Leu Pro Ala Ser Ala Val 
        355                 360                 365


Ala Pro Gly Pro Ser Ala Leu Asp Arg Lys Val Thr Pro Leu Gln Lys 
    370                 375                 380


Glu Leu Gln Glu Thr Leu Lys Gly Leu Leu Gly Ser Ala Asp Lys Gly 
385                 390                 395                 400


Ser Leu Glu Val Ala Thr Gln Tyr Gly Trp Val Leu Asp Ala Glu Val 
                405                 410                 415


Leu Leu Asp Ser Asp Gly Glu Phe Leu Pro Val Arg Asp Phe Val Ala 
            420                 425                 430


Pro His Leu Ala Gln Pro Thr Gly Ser Gln Ser Pro Pro Pro Gly Ser 
        435                 440                 445


Lys Arg Leu Ala Phe Leu Arg Trp Glu Phe Pro Asn Phe Asn Ser Arg 
    450                 455                 460


Ser Lys Asp Leu Leu Gly Arg Phe Val Leu Ala Arg Arg His Ile Val 
465                 470                 475                 480


Ala Ala Gly Phe Leu Ile Val Asp Val Pro Phe Tyr Glu Trp Leu Glu 
                485                 490                 495


Leu Lys Ser Glu Trp Gln Lys Gly Ala Tyr Leu Lys Asp Lys Met Arg 
            500                 505                 510


Lys Ala Val Ala Glu Glu Leu Ala Lys 
        515                 520


<210>  3774
<211>  3410
<212>  DNA
<213>  Homo sapiens

<400>  3774
ttaccatctg ctctcttctg caaggctgga ttcagggcca aagggctcta gagccaccca     60

tgttgacact gtgggccctg tggacacagt acctgaatag cagttaccct cttcagaaac    120

aaagcaggca ccagcagaga ggacgggctg tggtgcaggt tccggaccca gaactatgta    180

gaaataagtt caccttcgtt tacctgtata gtgggactga tggttctcat aggatgttgg    240

tgtctcatgg gggtacgcac acagaaggat gcctggcatt tagtaagagc ctgttcagag    300

gtgctgctgg tagcagcagc agcttggtca tccctaggag gcctctgcat ttgggagtgg    360

gcagggctta gtgataccgg gggtcttttt acccatatgt caaaagcgtt cctgcaaacc    420

tttgtgcctg gggtgctcct ccctttgcag gcagttgagg gtctggcatg cttgggtgcc    480

gcgtccctgg agggtaaagg tggtggttca ctgcctaacg cactgcaggg actcctgctt    540

attgcagcag ttgcattcct aagaaacttt cacgttgcca gaaactgcga gattggtttg    600

ttagagaaca gtttaggggt tggagcttct ctgactcaaa aacaaattat tttcctggag    660

aaaagccagt gtgttttgtt ttgttgtttg agacagagtc tcactctgtc acccaggctg    720

gagtgcagtg gcacaatctc agctcactgc agcctccacc ttccaggttc aagtgatctt    780

cccacctcag cctcccaagt aggtgggact acaggcatgt gccaccacac ctggctaatt    840

tttgtaattt taataggcac agggtttcac cacgttcacc aggctagtct cgaactcctg    900

acctcaggtg atctgcctgg cccaagtttt taatacctaa aacttttaat gtcgttgcaa    960

gtaaaagtca cgaatgataa caaaactgat cttagcaagc gtaagtgcca ccttctctgc   1020

catcaggtga catccatcag gctcaacttt ttctctgacc tcttgtattg atttgacagc   1080

tttacttgca gctgaagtct acgtgcccac tacccagagc tgtagccagg accatgtaaa   1140

agagtgtggt ctctctttaa tcaactacat taggtcaaaa cttcattggg gaaacttgga   1200

gaatttccct tgccactcta gagttcttgc ttgcaagcaa ttgcaaatga cctcagccac   1260

cttgagcaga aatgtgctat ttattgtagc ctagaggatc aggctcagag gtgtaccctt   1320

ggatctggcc tgtgcctgag gggtgctctg gctctgcagg tgcttggcag ccatgtcaaa   1380

ttcagtgcct gccctgtcta tggtaggcac tggcccagaa gactgccaca gaaacagtga   1440

ctcacaggcc ctgttactgt gtcccaggct cagggataaa tttggttaca gacaccaagc   1500

gtctaggcct cgaggctgag caaggctgtg aggagcagcc aggcactggg gccctgttac   1560

aatggagtgg ggaactgata ctgtcttctc tgaagagttg tagtaaatgc tcatgaaaca   1620

aggttcagag aggtagcctc cagctcacac acaggactga cagtgccaca tcatttctcc   1680

tgtgtccttt ctctgcctag attgcctcgg tctggcatgg taccctctcg aagctgctgg   1740

gaagcctgta tgctctgggc atccccaagg cctccaagga gctgcagtcg gtggagcagg   1800

aggtccgctg gcgcatgcgg aagctcaagt acaagcacct ggccttcctg gcagagtcct   1860

gtgccaccct ctcacaggag cagcactcgc aggagctgct ggctgagctg ctcacacacc   1920

tggaaaggcg ttggacagaa attgaagatt cccacacatt agtgaccgtc atgatgaagg   1980

tgggacacct ctcggagcca ctaatgaacc gcctggaaga caagtgcctg gagttggtgg   2040

agcactttgg ccccaatgag ctgcggaagg tgctggtgat gctggcagct cagagccggc   2100

ggtccgtgcc cttgctgcgg gccatctcct accacctggt gcagaagccc ttctctctga   2160

cgaaagatgt gctcttggac gtggcctatg cctatggcaa actcagcttt caccagaccc   2220

aggtgtccca gcgcctggcc accgacctgc tatccctcat gcccagcctg acttctggtg   2280

aggtggccca ctgtgccaag tccttcgcct tactcaagtg gctcagcctg cccctgtttg   2340

aggcctttgc ccagcacgtc ctgaacagag cgcaggacat caccctgccc cacctgtgca   2400

gcgtacttct ggcttttgcg cgtctgaact tccatccaga ccaagaggat cagttcttca   2460

gcctggtaca tgagaagctg gggtcagagc tgccaggcct ggagccagcc ctgcaggtgg   2520

acctggtgtg ggccctgtgt gtgctgcagc aggcacggga agcagagctg caagccgtcc   2580

tccaccctga atttcacatc caatttctag ggggcaagtc tcagaaggat cagaacacct   2640

tccagaagct gctccacatc aacgccactg ccctgctgga gtaccccgag tactcgggtc   2700

cccttctgcc tgcctcggct gtggcccctg ggccctcagc ccttgacagg aaggtgaccc   2760

ccctgcaaaa ggagctgcag gagacgctga aggggctgct ggggagcgcc gacaagggca   2820

gcctcgaggt ggccacgcag tatggctggg tgctggatgc tgaggtgctg ctggacagtg   2880

acggcgagtt tctgcccgta agggactttg tggcacctca ccttgcccag ccaactggga   2940

gccagtcacc acctccaggg tctaagaggc tagcgttctt gcggtgggag ttccccaact   3000

tcaacagccg aagcaaggac ttgctgggtc gctttgttct ggcccggcga cacatagtgg   3060

ctgcaggctt cctgatagtg gacgtcccat tctatgagtg gctggaactc aagtctgaat   3120

ggcagaaagg cgcctacctc aaggacaaga tgcgcaaagc ggtggctgag gagctggcca   3180

agtgacttgt gccagcagca tggactgcgt gcctctccgc cggaggtcta gctgtgggcg   3240

gccaagaagg gtcacccttg aggacaaacc tctgtgcagg accttggcca gagtggggag   3300

ggtggccagc cactctgagg gacagaacgt cctcttgtgt ataataaacc tttaattttg   3360

gtgttggacc cctggggcct tcccaggctt ggtcaccctc tgcactgtca              3410


<210>  3775
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  3775

Met Arg Lys Leu Lys Tyr Lys His Leu Ala Phe Leu Ala Glu Ser Cys 
1               5                   10                  15


Ala Thr Leu Ser Gln Glu Gln His Ser Gln Glu Leu Leu Ala Glu Leu 
            20                  25                  30


Leu Thr His Leu Glu Arg Arg Trp Thr Glu Ile Glu Asp Ser His Thr 
        35                  40                  45


Leu Val Thr Val Met Met Lys Val Gly His Leu Ser Glu Pro Leu Met 
    50                  55                  60


Asn Arg Leu Glu Asp Lys Cys Leu Glu Leu Val Glu His Phe Gly Pro 
65                  70                  75                  80


Asn Glu Leu Arg Lys Val Leu Val Met Leu Ala Ala Gln Ser Arg Arg 
                85                  90                  95


Ser Val Pro Leu Leu Arg Ala Ile Ser Tyr His Leu Val Gln Lys Pro 
            100                 105                 110


Phe Ser Leu Thr Lys Asp Val Leu Leu Asp Val Ala Tyr Ala Tyr Gly 
        115                 120                 125


Lys Leu Ser Phe His Gln Thr Gln Val Ser Gln Arg Leu Ala Thr Asp 
    130                 135                 140


Leu Leu Ser Leu Met Pro Ser Leu Thr Ser Gly Glu Val Ala His Cys 
145                 150                 155                 160


Ala Lys Ser Phe Ala Leu Leu Lys Trp Leu Ser Leu Pro Leu Phe Glu 
                165                 170                 175


Ala Phe Ala Gln His Val Leu Asn Arg Ala Gln Asp Ile Thr Leu Pro 
            180                 185                 190


His Leu Cys Ser Val Leu Leu Ala Phe Ala Arg Leu Asn Phe His Pro 
        195                 200                 205


Asp Gln Glu Asp Gln Phe Phe Ser Leu Val His Glu Lys Leu Gly Ser 
    210                 215                 220


Glu Leu Pro Gly Leu Glu Pro Ala Leu Gln Val Asp Leu Val Trp Ala 
225                 230                 235                 240


Leu Cys Val Leu Gln Gln Ala Arg Glu Ala Glu Leu Gln Ala Val Leu 
                245                 250                 255


His Pro Glu Phe His Ile Gln Phe Leu Gly Gly Lys Ser Gln Lys Asp 
            260                 265                 270


Gln Asn Thr Phe Gln Lys Leu Leu His Ile Asn Ala Thr Ala Leu Leu 
        275                 280                 285


Glu Tyr Pro Glu Tyr Ser Gly Pro Leu Leu Pro Ala Ser Ala Val Ala 
    290                 295                 300


Pro Gly Pro Ser Ala Leu Asp Arg Lys Val Thr Pro Leu Gln Lys Glu 
305                 310                 315                 320


Leu Gln Glu Thr Leu Lys Gly Leu Leu Gly Ser Ala Asp Lys Gly Ser 
                325                 330                 335


Leu Glu Val Ala Thr Gln Tyr Gly Trp Val Leu Asp Ala Glu Val Leu 
            340                 345                 350


Leu Asp Ser Asp Gly Glu Phe Leu Pro Val Arg Asp Phe Val Ala Pro 
        355                 360                 365


His Leu Ala Gln Pro Thr Gly Ser Gln Ser Pro Pro Pro Gly Ser Lys 
    370                 375                 380


Arg Leu Ala Phe Leu Arg Trp Glu Phe Pro Asn Phe Asn Ser Arg Ser 
385                 390                 395                 400


Lys Asp Leu Leu Gly Arg Phe Val Leu Ala Arg Arg His Ile Val Ala 
                405                 410                 415


Ala Gly Phe Leu Ile Val Asp Val Pro Phe Tyr Glu Trp Leu Glu Leu 
            420                 425                 430


Lys Ser Glu Trp Gln Lys Gly Ala Tyr Leu Lys Asp Lys Met Arg Lys 
        435                 440                 445


Ala Val Ala Glu Glu Leu Ala Lys 
    450                 455


<210>  3776
<211>  2276
<212>  DNA
<213>  Homo sapiens

<400>  3776
tcgtttccgc cggcgctccg agtgacgtag ggaagcgcgc cgcgcacctc atggttccgg     60

ggacagttag ggcggcggat ggaggtcagc ggtggtgctc gctgcggttt ggaatcactt    120

gctaggagtc ttgtctctct gccacccagg acatcatggc agctcacctg gtaaagcgat    180

gcacgtgcct cctgagagaa gctgctcgtc aggcccctgc catggctcca gttggccgac    240

tgagacttgc ctgggtagcc cataagactc tgacttcctc agccacctca cccatttccc    300

acctcccagg ttccttgatg gagccggtgg agaaggaacg agcatctact ccctacatag    360

agaagcaggt ggaccacctc atcaagaagg ccacaaggcc agaggagctc ctggagctac    420

ttggtggcag tcacgacttg gacagcaatc aagcagcaat ggtacttatc cggctctctc    480

acttgctgtc tgagaagcca gaagataaag gcttgctcat acaggatgcc cactttcatc    540

aacttctctg tctgctcaac agtcagattg cctcggtctg gcatggtacc ctctcgaagc    600

tgctgggaag cctgtatgct ctgggcatcc ccaaggcctc caaggagctg cagtcggtgg    660

agcaggaggt ccgctggcgc atgcggaagc tcaagtacaa gcacctggcc ttcctggcag    720

agtcctgtgc caccctctca caggagcagc actcgcagga gctgctggct gagctgctca    780

cacacctgga aaggcgttgg acagaaattg aagattccca cacattagtg accgtcatga    840

tgaaggtggg acacctctcg gagccactaa tgaaccgcct ggaagacaag tgcctggagt    900

tggtggagca ctttggcccc aatgagctgc ggaaggtgct ggtgatgctg gcagctcaga    960

gccggcggtc cgtgcccttg ctgcgggcca tctcctacca cctggtgcag aagcccttct   1020

ctctgacgaa agatgtgctc ttggacgtgg cctatgccta tggcaaactc agctttcacc   1080

agacccaggt gtcccagcgc ctggccaccg acctgctatc cctcatgccc agcctgactt   1140

ctggtgaggt ggcccactgt gccaagtcct tcgccttact caagtggctc agcctgcccc   1200

tgtttgaggc ctttgcccag cacgtcctga acagagcgca ggacatcacc ctgccccacc   1260

tgtgcagcgt acttctggct tttgcgcgtc tgaacttcca tccagaccaa gaggatcagt   1320

tcttcagcct ggtacatgag aagctggggt cagagctgcc aggcctggag ccagccctgc   1380

aggtggacct ggtgtgggcc ctgtgtgtgc tgcagcaggc acgggaagca gagctgcaag   1440

ccgtcctcca ccctgaattt cacatccaat ttctaggggg caagtctcag aaggatcaga   1500

acaccttcca gaagctgctc cacatcaacg ccactgccct gctggagtac cccgagtact   1560

cgggtcccct tctgcctgcc tcggctgtgg cccctgggcc ctcagccctt gacaggaagg   1620

tgacccccct gcaaaaggag ctgcaggaga cgctgaaggg gctgctgggg agcgccgaca   1680

agggcagcct cgaggtggcc acgcagtatg gctgggtgct ggatgctgag gtgctgctgg   1740

acagtgacgg cgagtttctg cccgtaaggg actttgtggc acctcacctt gcccagccaa   1800

ctgggagcca gtcaccacct ccagggtcta agaggctagc gttcttgcgg tgggagttcc   1860

ccaacttcaa cagccgaagc aaggacttgc tgggtcgctt tgttctggcc cggcgacaca   1920

tagtggctgc aggcttcctg atagtggacg tcccattcta tgagtggctg gaactcaagt   1980

ctgaatggca gaaaggcgcc tacctcaagg acaagatgcg caaagcggtg gctgaggagc   2040

tggccaagtg acttgtgcca gcagcatgga ctgcgtgcct ctccgccgga ggtctagctg   2100

tgggcggcca agaagggtca cccttgagga caaacctctg tgcaggacct tggccagagt   2160

ggggagggtg gccagccact ctgagggaca gaacgtcctc ttgtgtataa taaaccttta   2220

attttggtgt tggacccctg gggccttccc aggcttggtc accctctgca ctgtca       2276


<210>  3777
<211>  631
<212>  PRT
<213>  Homo sapiens

<400>  3777

Met Ala Ala His Leu Val Lys Arg Cys Thr Cys Leu Leu Arg Glu Ala 
1               5                   10                  15


Ala Arg Gln Ala Pro Ala Met Ala Pro Val Gly Arg Leu Arg Leu Ala 
            20                  25                  30


Trp Val Ala His Lys Thr Leu Thr Ser Ser Ala Thr Ser Pro Ile Ser 
        35                  40                  45


His Leu Pro Gly Ser Leu Met Glu Pro Val Glu Lys Glu Arg Ala Ser 
    50                  55                  60


Thr Pro Tyr Ile Glu Lys Gln Val Asp His Leu Ile Lys Lys Ala Thr 
65                  70                  75                  80


Arg Pro Glu Glu Leu Leu Glu Leu Leu Gly Gly Ser His Asp Leu Asp 
                85                  90                  95


Ser Asn Gln Ala Ala Met Val Leu Ile Arg Leu Ser His Leu Leu Ser 
            100                 105                 110


Glu Lys Pro Glu Asp Lys Gly Leu Leu Ile Gln Asp Ala His Phe His 
        115                 120                 125


Gln Leu Leu Cys Leu Leu Asn Ser Gln Ile Ala Ser Val Trp His Gly 
    130                 135                 140


Thr Leu Ser Lys Leu Leu Gly Ser Leu Tyr Ala Leu Gly Ile Pro Lys 
145                 150                 155                 160


Ala Ser Lys Glu Leu Gln Ser Val Glu Gln Glu Val Arg Trp Arg Met 
                165                 170                 175


Arg Lys Leu Lys Tyr Lys His Leu Ala Phe Leu Ala Glu Ser Cys Ala 
            180                 185                 190


Thr Leu Ser Gln Glu Gln His Ser Gln Glu Leu Leu Ala Glu Leu Leu 
        195                 200                 205


Thr His Leu Glu Arg Arg Trp Thr Glu Ile Glu Asp Ser His Thr Leu 
    210                 215                 220


Val Thr Val Met Met Lys Val Gly His Leu Ser Glu Pro Leu Met Asn 
225                 230                 235                 240


Arg Leu Glu Asp Lys Cys Leu Glu Leu Val Glu His Phe Gly Pro Asn 
                245                 250                 255


Glu Leu Arg Lys Val Leu Val Met Leu Ala Ala Gln Ser Arg Arg Ser 
            260                 265                 270


Val Pro Leu Leu Arg Ala Ile Ser Tyr His Leu Val Gln Lys Pro Phe 
        275                 280                 285


Ser Leu Thr Lys Asp Val Leu Leu Asp Val Ala Tyr Ala Tyr Gly Lys 
    290                 295                 300


Leu Ser Phe His Gln Thr Gln Val Ser Gln Arg Leu Ala Thr Asp Leu 
305                 310                 315                 320


Leu Ser Leu Met Pro Ser Leu Thr Ser Gly Glu Val Ala His Cys Ala 
                325                 330                 335


Lys Ser Phe Ala Leu Leu Lys Trp Leu Ser Leu Pro Leu Phe Glu Ala 
            340                 345                 350


Phe Ala Gln His Val Leu Asn Arg Ala Gln Asp Ile Thr Leu Pro His 
        355                 360                 365


Leu Cys Ser Val Leu Leu Ala Phe Ala Arg Leu Asn Phe His Pro Asp 
    370                 375                 380


Gln Glu Asp Gln Phe Phe Ser Leu Val His Glu Lys Leu Gly Ser Glu 
385                 390                 395                 400


Leu Pro Gly Leu Glu Pro Ala Leu Gln Val Asp Leu Val Trp Ala Leu 
                405                 410                 415


Cys Val Leu Gln Gln Ala Arg Glu Ala Glu Leu Gln Ala Val Leu His 
            420                 425                 430


Pro Glu Phe His Ile Gln Phe Leu Gly Gly Lys Ser Gln Lys Asp Gln 
        435                 440                 445


Asn Thr Phe Gln Lys Leu Leu His Ile Asn Ala Thr Ala Leu Leu Glu 
    450                 455                 460


Tyr Pro Glu Tyr Ser Gly Pro Leu Leu Pro Ala Ser Ala Val Ala Pro 
465                 470                 475                 480


Gly Pro Ser Ala Leu Asp Arg Lys Val Thr Pro Leu Gln Lys Glu Leu 
                485                 490                 495


Gln Glu Thr Leu Lys Gly Leu Leu Gly Ser Ala Asp Lys Gly Ser Leu 
            500                 505                 510


Glu Val Ala Thr Gln Tyr Gly Trp Val Leu Asp Ala Glu Val Leu Leu 
        515                 520                 525


Asp Ser Asp Gly Glu Phe Leu Pro Val Arg Asp Phe Val Ala Pro His 
    530                 535                 540


Leu Ala Gln Pro Thr Gly Ser Gln Ser Pro Pro Pro Gly Ser Lys Arg 
545                 550                 555                 560


Leu Ala Phe Leu Arg Trp Glu Phe Pro Asn Phe Asn Ser Arg Ser Lys 
                565                 570                 575


Asp Leu Leu Gly Arg Phe Val Leu Ala Arg Arg His Ile Val Ala Ala 
            580                 585                 590


Gly Phe Leu Ile Val Asp Val Pro Phe Tyr Glu Trp Leu Glu Leu Lys 
        595                 600                 605


Ser Glu Trp Gln Lys Gly Ala Tyr Leu Lys Asp Lys Met Arg Lys Ala 
    610                 615                 620


Val Ala Glu Glu Leu Ala Lys 
625                 630


<210>  3778
<211>  790
<212>  DNA
<213>  Homo sapiens

<400>  3778
tagggggcaa gtctcagaag gatcagaaca ccttccagaa gctgctccac atcaacgcca     60

ctgccctgct ggagtacccc gagtactcgg gtccccttct gcctgcctcg gctgtggccc    120

ctgggccctc agcccttgac aggaaggtga cccccctgca aaaggagctg caggagacgc    180

tgaaggggct gctggggagc gccgacaagg gcagcctcga ggtggccacg cagtatggct    240

gggtgctggg tgagggctcc ccctggttgg cacagggcct ggcattgcct gagtctaacg    300

ggactcttct aacccacccc gtctgcagca agtactgacc tagggagctg cagggtgtca    360

gcctgggctc cccacagtcc catctttgtt catctttcct gtgggggggt ttctgaggga    420

tgtcccccaa catgttctca tcccacaccc cttccccaga tgctgaggtg ctgctggaca    480

gtgacggcga gtttctgccc gtaagggact ttgtggcacc tcaccttgcc cagccaactg    540

ggagccagtc accacctcca gggtctaaga ggctagcgtt cttgcggtgg gagttcccca    600

acttcaacag ccgaagcaag gacttgctgg gtcgctttgt tctggcccgg cgacacatag    660

tggctgcagg cttcctgata gtggacgtga ccactctgag ggacagaacg tcctcttgtg    720

tataataaac ctttaatttt ggtgttggac ccctggggcc ttcccaggct tggtcaccct    780

ctgcactgtc                                                           790


<210>  3779
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  3779

Met Ser Pro Asn Met Phe Ser Ser His Thr Pro Ser Pro Asp Ala Glu 
1               5                   10                  15


Val Leu Leu Asp Ser Asp Gly Glu Phe Leu Pro Val Arg Asp Phe Val 
            20                  25                  30


Ala Pro His Leu Ala Gln Pro Thr Gly Ser Gln Ser Pro Pro Pro Gly 
        35                  40                  45


Ser Lys Arg Leu Ala Phe Leu Arg Trp Glu Phe Pro Asn Phe Asn Ser 
    50                  55                  60


Arg Ser Lys Asp Leu Leu Gly Arg Phe Val Leu Ala Arg Arg His Ile 
65                  70                  75                  80


Val Ala Ala Gly Phe Leu Ile Val Asp Val Thr Thr Leu Arg Asp Arg 
                85                  90                  95


Thr Ser Ser Cys Val 
            100


<210>  3780
<211>  1945
<212>  DNA
<213>  Homo sapiens

<400>  3780
tcgtttccgc cggcgctccg agtgacgtag ggaagcgcgc cgcgcacctc atggttccgg     60

ggacagttag ggcggcggat ggaggtcagc ggtggtgctc gctgcggttt ggaatcactt    120

gctaggagtc ttgtctctct gccacccagg acatcatggc agctcacctg gtaaagcgat    180

gcacgtgcct cctgagagaa gctgctcgtc aggcccctgc catggctcca gttggccgac    240

tgagacttgc ctgggtagcc cataagactc tgacttcctc agccacctca cccatttccc    300

acctcccagg ttccttgatg gagccggtgg agaaggaacg agcatctact ccctacatag    360

agaagcaggt ggaccacctc atcaagaagg ccacaaggcc agaggagctc ctggagctac    420

ttggtggcag tcacgacttg gacagcaatc aagcagcaat ggtacttatc cggctctctc    480

acttgctgtc tgagaagcca gaagataaag gcttgctcat acaggatgcc cactttcatc    540

aacttctctg tctgctcaac agtcagattg cctcggtctg gcatggtacc ctctcgaagc    600

tgctgggaag cctgtatgct ctgggcatcc ccaaggcctc caaggagctg cagtcggtgg    660

agcaggaggt ccgctggcgc atgcggaagc tcaagtacaa gcacctggcc ttcctggcag    720

agtcctgtgc caccctctca caggagcagc actcgcagga gctgctggct gagctgctca    780

cacacctgga aaggcgttgg acagaaattg aagattccca cacattagtg accgtcatga    840

tgaaggtggg acacctctcg gagccactaa tgaaccgcct ggaagacaag cacgtcctga    900

acagagcgca ggacatcacc ctgccccacc tgtgcagcgt acttctggct tttgcgcgtc    960

tgaacttcca tccagaccaa gaggatcagt tcttcagcct ggtacatgag aagctggggt   1020

cagagctgcc aggcctggag ccagccctgc aggtggacct ggtgtgggcc ctgtgtgtgc   1080

tgcagcaggc acgggaagca gagctgcaag ccgtcctcca ccctgaattt cacatccaat   1140

ttctaggggg caagtctcag aaggatcaga acaccttcca gaagctgctc cacatcaacg   1200

ccactgccct gctggagtac cccgagtact cgggtcccct tctgcctgcc tcggctgtgg   1260

cccctgggcc ctcagccctt gacaggaagg tgacccccct gcaaaaggag ctgcaggaga   1320

cgctgaaggg gctgctgggg agcgccgaca agggcagcct cgaggtggcc acgcagtatg   1380

gctgggtgct ggatgctgag gtgctgctgg acagtgacgg cgagtttctg cccgtaaggg   1440

actttgtggc acctcacctt gcccagccaa ctgggagcca gtcaccacct ccagggtcta   1500

agaggctagc gttcttgcgg tgggagttcc ccaacttcaa cagccgaagc aaggacttgc   1560

tgggtcgctt tgttctggcc cggcgacaca tagtggctgc aggcttcctg atagtggacg   1620

tcccattcta tgagtggctg gaactcaagt ctgaatggca gaaaggcgcc tacctcaagg   1680

acaagatgcg caaagcggtg gctgaggagc tggccaagtg acttgtgcca gcagcatgga   1740

ctgcgtgcct ctccgccgga ggtctagctg tgggcggcca agaagggtca cccttgagga   1800

caaacctctg tgcaggacct tggccagagt ggggagggtg gccagccact ctgagggaca   1860

gaacgtcctc ttgtgtataa taaaccttta attttggtgt tggacccctg gggccttccc   1920

aggcttggtc accctctgca ctgtc                                         1945


<210>  3781
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  3781

Met Ala Ala His Leu Val Lys Arg Cys Thr Cys Leu Leu Arg Glu Ala 
1               5                   10                  15


Ala Arg Gln Ala Pro Ala Met Ala Pro Val Gly Arg Leu Arg Leu Ala 
            20                  25                  30


Trp Val Ala His Lys Thr Leu Thr Ser Ser Ala Thr Ser Pro Ile Ser 
        35                  40                  45


His Leu Pro Gly Ser Leu Met Glu Pro Val Glu Lys Glu Arg Ala Ser 
    50                  55                  60


Thr Pro Tyr Ile Glu Lys Gln Val Asp His Leu Ile Lys Lys Ala Thr 
65                  70                  75                  80


Arg Pro Glu Glu Leu Leu Glu Leu Leu Gly Gly Ser His Asp Leu Asp 
                85                  90                  95


Ser Asn Gln Ala Ala Met Val Leu Ile Arg Leu Ser His Leu Leu Ser 
            100                 105                 110


Glu Lys Pro Glu Asp Lys Gly Leu Leu Ile Gln Asp Ala His Phe His 
        115                 120                 125


Gln Leu Leu Cys Leu Leu Asn Ser Gln Ile Ala Ser Val Trp His Gly 
    130                 135                 140


Thr Leu Ser Lys Leu Leu Gly Ser Leu Tyr Ala Leu Gly Ile Pro Lys 
145                 150                 155                 160


Ala Ser Lys Glu Leu Gln Ser Val Glu Gln Glu Val Arg Trp Arg Met 
                165                 170                 175


Arg Lys Leu Lys Tyr Lys His Leu Ala Phe Leu Ala Glu Ser Cys Ala 
            180                 185                 190


Thr Leu Ser Gln Glu Gln His Ser Gln Glu Leu Leu Ala Glu Leu Leu 
        195                 200                 205


Thr His Leu Glu Arg Arg Trp Thr Glu Ile Glu Asp Ser His Thr Leu 
    210                 215                 220


Val Thr Val Met Met Lys Val Gly His Leu Ser Glu Pro Leu Met Asn 
225                 230                 235                 240


Arg Leu Glu Asp Lys His Val Leu Asn Arg Ala Gln Asp Ile Thr Leu 
                245                 250                 255


Pro His Leu Cys Ser Val Leu Leu Ala Phe Ala Arg Leu Asn Phe His 
            260                 265                 270


Pro Asp Gln Glu Asp Gln Phe Phe Ser Leu Val His Glu Lys Leu Gly 
        275                 280                 285


Ser Glu Leu Pro Gly Leu Glu Pro Ala Leu Gln Val Asp Leu Val Trp 
    290                 295                 300


Ala Leu Cys Val Leu Gln Gln Ala Arg Glu Ala Glu Leu Gln Ala Val 
305                 310                 315                 320


Leu His Pro Glu Phe His Ile Gln Phe Leu Gly Gly Lys Ser Gln Lys 
                325                 330                 335


Asp Gln Asn Thr Phe Gln Lys Leu Leu His Ile Asn Ala Thr Ala Leu 
            340                 345                 350


Leu Glu Tyr Pro Glu Tyr Ser Gly Pro Leu Leu Pro Ala Ser Ala Val 
        355                 360                 365


Ala Pro Gly Pro Ser Ala Leu Asp Arg Lys Val Thr Pro Leu Gln Lys 
    370                 375                 380


Glu Leu Gln Glu Thr Leu Lys Gly Leu Leu Gly Ser Ala Asp Lys Gly 
385                 390                 395                 400


Ser Leu Glu Val Ala Thr Gln Tyr Gly Trp Val Leu Asp Ala Glu Val 
                405                 410                 415


Leu Leu Asp Ser Asp Gly Glu Phe Leu Pro Val Arg Asp Phe Val Ala 
            420                 425                 430


Pro His Leu Ala Gln Pro Thr Gly Ser Gln Ser Pro Pro Pro Gly Ser 
        435                 440                 445


Lys Arg Leu Ala Phe Leu Arg Trp Glu Phe Pro Asn Phe Asn Ser Arg 
    450                 455                 460


Ser Lys Asp Leu Leu Gly Arg Phe Val Leu Ala Arg Arg His Ile Val 
465                 470                 475                 480


Ala Ala Gly Phe Leu Ile Val Asp Val Pro Phe Tyr Glu Trp Leu Glu 
                485                 490                 495


Leu Lys Ser Glu Trp Gln Lys Gly Ala Tyr Leu Lys Asp Lys Met Arg 
            500                 505                 510


Lys Ala Val Ala Glu Glu Leu Ala Lys 
        515                 520


<210>  3782
<211>  1136
<212>  DNA
<213>  Homo sapiens

<400>  3782
ggggagcctt ctttatgaag accttaggac agccacagag gccagcaggc caggtgtgat     60

cccaggctcc ctgggattcc atcaggggtt tgtctggcac agtcctgaga acaattagcc    120

aggggctggg gagtgctgct tcacctcttg gatgctctca tctctcagag gaccagagat    180

tcctccttcc ttgtcccagg tgctcacttg gagacattat gggagaaggg atcttgttcc    240

ctgccagtag gttggttgta gtaaacctaa tcaaatgcca gcattcagca gcactcttct    300

gctgttcaga gtggtcttgg ggcatgagga agattcctgg taccttcaag cccaggattg    360

ctccaggcct caccaagggc cagggttctg cctcttgtta cctagtagcc tcctctggcc    420

tcatcccaac caggccaaga ccacatcatg gattgtgtct cacccatggc tatttgcagc    480

ccctaaggag agcctgcttt ctccaccaca ctctatcctt gcccaggtac atgagaagct    540

ggggtcagag ctgccaggcc tggagccagc cctgcaggtg gacctggtgt gggccctgtg    600

tgtgctgcag caggcacggg aagcagagct gcaagccgtc ctccaccctg aatttcacat    660

ccaatttcta gggggcaagt ctcagaagga tcagaacacc ttccagaagc tgctccacat    720

caacgccact gccctgctgg agtaccccga gtactcgggt ccccttctgc ctgcctcggc    780

tgtggcccct gggccctcag cccttgacag gaaggtgacc cccctgcaaa aggagctgca    840

ggagacgctg aaggggctgc tggggagcgc cgacaagggc agcctcgagg tggccacgca    900

gtatggctgg gtgctgggtg agggctcccc ctggttggca cagggcctgg cattgcctga    960

gtctaacggg actcttctaa cccaccccgt ctgcagcaag tactgaccta gggagctgca   1020

gggtgtcagc ctgggctccc cacagtccca tctttgttca tctttcctgt gggggggttt   1080

ctgagggatg tcccccaaca tgttctcatc ccacacccct tccccagatg ctgagg       1136


<210>  3783
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  3783

Met Pro Ala Phe Ser Ser Thr Leu Leu Leu Phe Arg Val Val Leu Gly 
1               5                   10                  15


His Glu Glu Asp Ser Trp Tyr Leu Gln Ala Gln Asp Cys Ser Arg Pro 
            20                  25                  30


His Gln Gly Pro Gly Phe Cys Leu Leu Leu Pro Ser Ser Leu Leu Trp 
        35                  40                  45


Pro His Pro Asn Gln Ala Lys Thr Thr Ser Trp Ile Val Ser His Pro 
    50                  55                  60


Trp Leu Phe Ala Ala Pro Lys Glu Ser Leu Leu Ser Pro Pro His Ser 
65                  70                  75                  80


Ile Leu Ala Gln Val His Glu Lys Leu Gly Ser Glu Leu Pro Gly Leu 
                85                  90                  95


Glu Pro Ala Leu Gln Val Asp Leu Val Trp Ala Leu Cys Val Leu Gln 
            100                 105                 110


Gln Ala Arg Glu Ala Glu Leu Gln Ala Val Leu His Pro Glu Phe His 
        115                 120                 125


Ile Gln Phe Leu Gly Gly Lys Ser Gln Lys Asp Gln Asn Thr Phe Gln 
    130                 135                 140


Lys Leu Leu His Ile Asn Ala Thr Ala Leu Leu Glu Tyr Pro Glu Tyr 
145                 150                 155                 160


Ser Gly Pro Leu Leu Pro Ala Ser Ala Val Ala Pro Gly Pro Ser Ala 
                165                 170                 175


Leu Asp Arg Lys Val Thr Pro Leu Gln Lys Glu Leu Gln Glu Thr Leu 
            180                 185                 190


Lys Gly Leu Leu Gly Ser Ala Asp Lys Gly Ser Leu Glu Val Ala Thr 
        195                 200                 205


Gln Tyr Gly Trp Val Leu Gly Glu Gly Ser Pro Trp Leu Ala Gln Gly 
    210                 215                 220


Leu Ala Leu Pro Glu Ser Asn Gly Thr Leu Leu Thr His Pro Val Cys 
225                 230                 235                 240


Ser Lys Tyr 



<210>  3784
<211>  666
<212>  DNA
<213>  Homo sapiens

<400>  3784
ggggagcgct ggccctgcag atgcctgcag ccgtgtcaaa ttcagtacct gtcctatgca     60

tggtaggcac tggcccagaa ggctgccaca gaaacactgt gactcatggg ccctgttcct    120

gtgtcccagg ctcagggata aatttggtta cagacatcaa atatctagac ctcgaggctg    180

aggtggggtg gagctgctgg gtgattgctg actctctcca gctaaaccct gtgatctgct    240

ctgtcctgaa ggcaaactca gctttcacca gacccaggtg tcccagcgcc tggccaccga    300

cctgctatcc ctcatgccca gcctgacttc tggtgaggtg gcccactgtg ccaagtcctt    360

cgccttactc aagtggctca gcctgcccct gtttgaggcc tttgcccagc acgtcctgaa    420

cagagcgcag gacatcaccc tgccccacct gtgcagcgta cttctggctt ttgcgcgtct    480

gaacttccat ccagaccaag aggatcagtt cttcagcctg gtacatgaga agctggggtc    540

agagctgcca ggcctggagc cagccctgca ggtggacctg gtgtgggccc tgtgtgtgct    600

gcagcaggca cgggaagcag agctgcaagc cgtcctccac cctgaatttc acatccaatt    660

tctagg                                                               666


<210>  3785
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  3785

Met Pro Ser Leu Thr Ser Gly Glu Val Ala His Cys Ala Lys Ser Phe 
1               5                   10                  15


Ala Leu Leu Lys Trp Leu Ser Leu Pro Leu Phe Glu Ala Phe Ala Gln 
            20                  25                  30


His Val Leu Asn Arg Ala Gln Asp Ile Thr Leu Pro His Leu Cys Ser 
        35                  40                  45


Val Leu Leu Ala Phe Ala Arg Leu Asn Phe His Pro Asp Gln Glu Asp 
    50                  55                  60


Gln Phe Phe Ser Leu Val His Glu Lys Leu Gly Ser Glu Leu Pro Gly 
65                  70                  75                  80


Leu Glu Pro Ala Leu Gln Val Asp Leu Val Trp Ala Leu Cys Val Leu 
                85                  90                  95


Gln Gln Ala Arg Glu Ala Glu Leu Gln Ala Val Leu His Pro Glu Phe 
            100                 105                 110


His Ile Gln Phe 
        115


<210>  3786
<211>  950
<212>  DNA
<213>  Homo sapiens

<400>  3786
tctgctggga accattgcct tagtcgggaa agtaaagcca gtctgaaaat gctcacttgt     60

gggggcaaat acatatttct tgcattttgg cttattttga aagggctgct attcagttct    120

caaaaaagtg tttgagaact gtttcctctg ttctttcact gaccattata agtgcttcca    180

tccattttgg ggtagctgta gcaggtagca gcatggctga tgagactgag aatccactga    240

gaactgtcta ctgaatcact gatccccctc gcaaagtgga actgtacaga aagatgacac    300

ctgcagttac gtttatgtgt gaccagtcta aactaagttt actggttgga gaatatttct    360

aaatccctta tcagaaagaa gccagcaggc caggtgtgat cccaggctcc ctgggattcc    420

atcaggggtt tgtctggcac agtcctgaga acaattagcc aggggctggg gagtgctgct    480

tcacctcttg gatgctctca tctctcagag gaccagagat tcctccttcc ttgtcccagg    540

tgctcacttg gagacattat gggagaaggg atcttgttcc ctgccagtag gttggttgta    600

gtaaacctaa tcaaatgcca gcattcagca gcactcttct gctgttcaga gtggtcttgg    660

ggcatgagga agattcctgg taccttcaag cccaggattg ctccaggcct caccaagggc    720

cagggttctg cctcttgtta cctagtagcc tcctctggcc tcatcccaac caggccaaga    780

ccacatcatg gattgtgtct cacccatggc tatttgcagc ccctaaggag agcctgcttt    840

ctccaccaca ctctatcctt gcccaggtac atgagaagct ggggtcagag ctgccaggcc    900

tggagccagc cctgcaggtg gacctggtgt gggccctgtg tgtgctgcag               950


<210>  3787
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  3787

Met Gly Glu Gly Ile Leu Phe Pro Ala Ser Arg Leu Val Val Val Asn 
1               5                   10                  15


Leu Ile Lys Cys Gln His Ser Ala Ala Leu Phe Cys Cys Ser Glu Trp 
            20                  25                  30


Ser Trp Gly Met Arg Lys Ile Pro Gly Thr Phe Lys Pro Arg Ile Ala 
        35                  40                  45


Pro Gly Leu Thr Lys Gly Gln Gly Ser Ala Ser Cys Tyr Leu Val Ala 
    50                  55                  60


Ser Ser Gly Leu Ile Pro Thr Arg Pro Arg Pro His His Gly Leu Cys 
65                  70                  75                  80


Leu Thr His Gly Tyr Leu Gln Pro Leu Arg Arg Ala Cys Phe Leu His 
                85                  90                  95


His Thr Leu Ser Leu Pro Arg Tyr Met Arg Ser Trp Gly Gln Ser Cys 
            100                 105                 110


Gln Ala Trp Ser Gln Pro Cys Arg Trp Thr Trp Cys Gly Pro Cys Val 
        115                 120                 125


Cys 



<210>  3788
<211>  624
<212>  DNA
<213>  Homo sapiens

<400>  3788
gaagcccttc tctctgacga aagatgtgct cttggacgtg gcctatgcct atggcaaact     60

cagctttcac cagacccagg tgtcccagcg cctggccacc gacctgctat ccctcatgcc    120

cagcctgact tctggtgagg tggcccactg tgccaagtcc ttcgccttac tcaagtggct    180

cagcctgccc ctgtttgagg cctttgccca gcacgtcctg aacagagcgc aggacatcac    240

cctgccccac ctgtgcagcg tacttctggc ttttgcgcgt ctgaacttcc atccagacca    300

agaggatcag ttcttcagcc tggtagggcc tctgggctcc cactgctcga cctttatcct    360

ccccttcagc taatggctca tgaaccgtcc tcccaagatc agctcgggct aggtggaggc    420

gggaggggcc actatgtgtg gcatgggagg gcagggggaa ctgattggag ccaggcatcc    480

tagggattac tgagaacaca tgaaatcctg ctgtctggtt gactgccctg ccaggcagcg    540

ctggggggtc ctgcctctgg tgctcctttt aatgccctgt tgatgctcag aagctccagt    600

gggccttcgt gctatgtgca ccag                                           624


<210>  3789
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  3789

Met Pro Ser Leu Thr Ser Gly Glu Val Ala His Cys Ala Lys Ser Phe 
1               5                   10                  15


Ala Leu Leu Lys Trp Leu Ser Leu Pro Leu Phe Glu Ala Phe Ala Gln 
            20                  25                  30


His Val Leu Asn Arg Ala Gln Asp Ile Thr Leu Pro His Leu Cys Ser 
        35                  40                  45


Val Leu Leu Ala Phe Ala Arg Leu Asn Phe His Pro Asp Gln Glu Asp 
    50                  55                  60


Gln Phe Phe Ser Leu Val Gly Pro Leu Gly Ser His Cys Ser Thr Phe 
65                  70                  75                  80


Ile Leu Pro Phe Ser 
                85


<210>  3790
<211>  134
<212>  DNA
<213>  Homo sapiens

<400>  3790
tgcagccgtg tcaaattcag tacctgtcct atgcatggta ggcactggcc cagaaggctg     60

ccacagaaac actgtgactc atgggccctg ttcctgtgtc ccaggctcag ggataaattt    120

ggttacagac atca                                                      134


<210>  3791
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  3791

Met His Gly Arg His Trp Pro Arg Arg Leu Pro Gln Lys His Cys Asp 
1               5                   10                  15


Ser Trp Ala Leu Phe Leu Cys Pro Arg Leu Arg Asp Lys Phe Gly Tyr 
            20                  25                  30


Arg 



<210>  3792
<211>  940
<212>  DNA
<213>  Homo sapiens

<400>  3792
ggtttggaat cacttgctag gagtcttgtc tctctgccac ccaggacatc atggcagctc     60

acctggtaaa gcgatgcacg tgcctcctga gagaagctgc tcgtcaggcc cctgccatgg    120

ctccagttgg ccgactgaga cttgcctggg tagcccataa gactctgact tcctcagcca    180

cctcacccat ttcccacctc ccaggttcct tgatggagcc ggtggagaag gaacgagcat    240

ctactcccta catagagaag caggtggacc acctcatcaa gaaggccaca aggccagagg    300

agctcctgga gctacttggt ggcagtcacg acttggacag caatcaagca gcaatggtac    360

ttatccggct ctctcacttg ctgtctgaga agccagaaga taaaggcttg ctcatacagg    420

atgcccactt tcatcaactt ctctgtctgc tcaacagtca gattgcctcg gtctggcatg    480

gtaccctctc gaagctgctg ggaagcctgt atgctctggg catccccaag gcctccaagg    540

agctgcagtc ggtggagcag gaggtccgct ggcgcatgcg gaagctcaag tacaagcacc    600

tggccttcct ggcagagtcc tgtgccaccc tctcacagga gcagcactcg caggagctgc    660

tggctgagct gctcacacac ctggaaaggc gttggacaga aattgaagat tcccacacat    720

tagtgaccgt catgatgaag gtgggacacc tctcggagcc actaatgaac cgcctggaag    780

acaaggtact gggcctgaaa gcaggtggca cccagcctgc ctcccctggg ctttgggctt    840

gttctttggg tgacagttgt ctgcagaggg gtgcgttgtg tgcactggga tcagagccct    900

gggagcttct gtctggagcc tcaggcatca catggggcag                          940


<210>  3793
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  3793

Met Ala Ala His Leu Val Lys Arg Cys Thr Cys Leu Leu Arg Glu Ala 
1               5                   10                  15


Ala Arg Gln Ala Pro Ala Met Ala Pro Val Gly Arg Leu Arg Leu Ala 
            20                  25                  30


Trp Val Ala His Lys Thr Leu Thr Ser Ser Ala Thr Ser Pro Ile Ser 
        35                  40                  45


His Leu Pro Gly Ser Leu Met Glu Pro Val Glu Lys Glu Arg Ala Ser 
    50                  55                  60


Thr Pro Tyr Ile Glu Lys Gln Val Asp His Leu Ile Lys Lys Ala Thr 
65                  70                  75                  80


Arg Pro Glu Glu Leu Leu Glu Leu Leu Gly Gly Ser His Asp Leu Asp 
                85                  90                  95


Ser Asn Gln Ala Ala Met Val Leu Ile Arg Leu Ser His Leu Leu Ser 
            100                 105                 110


Glu Lys Pro Glu Asp Lys Gly Leu Leu Ile Gln Asp Ala His Phe His 
        115                 120                 125


Gln Leu Leu Cys Leu Leu Asn Ser Gln Ile Ala Ser Val Trp His Gly 
    130                 135                 140


Thr Leu Ser Lys Leu Leu Gly Ser Leu Tyr Ala Leu Gly Ile Pro Lys 
145                 150                 155                 160


Ala Ser Lys Glu Leu Gln Ser Val Glu Gln Glu Val Arg Trp Arg Met 
                165                 170                 175


Arg Lys Leu Lys Tyr Lys His Leu Ala Phe Leu Ala Glu Ser Cys Ala 
            180                 185                 190


Thr Leu Ser Gln Glu Gln His Ser Gln Glu Leu Leu Ala Glu Leu Leu 
        195                 200                 205


Thr His Leu Glu Arg Arg Trp Thr Glu Ile Glu Asp Ser His Thr Leu 
    210                 215                 220


Val Thr Val Met Met Lys Val Gly His Leu Ser Glu Pro Leu Met Asn 
225                 230                 235                 240


Arg Leu Glu Asp Lys Val Leu Gly Leu Lys Ala Gly Gly Thr Gln Pro 
                245                 250                 255


Ala Ser Pro Gly Leu Trp Ala Cys Ser Leu Gly Asp Ser Cys Leu Gln 
            260                 265                 270


Arg Gly Ala Leu Cys Ala Leu Gly Ser Glu Pro Trp Glu Leu Leu Ser 
        275                 280                 285


Gly Ala Ser Gly Ile Thr Trp 
    290                 295


<210>  3794
<211>  779
<212>  DNA
<213>  Homo sapiens

<400>  3794
aagcgcgccg cgcacctcat ggttccgggg acagttaggg cggcggatgg aggtcagcgg     60

tggtgctcgc tgcggtttgg aatcacttgc taggagtctt gtctctctgc cacccaggac    120

atcatggcag ctcacctggt aaagcgatgc acgtgcctcc tgagagaagc tgctcgtcag    180

gcccctgcca tggctccagt tggccgactg agacttgcct gggtagccca taagactctg    240

acttcctcag ccacctcacc catttcccac ctcccaggtt ccttgatgga gccggtggag    300

aaggaacgag catctactcc ctacatagag aagcaggtgg accacctcat caagaaggcc    360

acaaggccag aggagctcct ggagctactt ggtggcagtc acgacttgga cagcaatcaa    420

gcagcaatgg tacttatccg gctctctcac ttgctgtctg agaagccaga agataaaggc    480

ttgctcatac aggatgccca ctgtatgctc tgggcatccc caaggcctcc aaggagctgc    540

agtcggtgga gcaggaggtc cgctggcgca tgcggaagct caagtacaag cacctggcct    600

tcctggcaga gtcctgtgcc accctctcac aggagcagca ctcgcaggag ctgctggctg    660

agctgctcac acacctggaa aggcgttgga cagaaattga agattcccac acattagtga    720

ccgtcatgat gaaggtggga cacctctcgg agccactaat gaaccgcctg gaagacaag     779


<210>  3795
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  3795

Met Ala Ala His Leu Val Lys Arg Cys Thr Cys Leu Leu Arg Glu Ala 
1               5                   10                  15


Ala Arg Gln Ala Pro Ala Met Ala Pro Val Gly Arg Leu Arg Leu Ala 
            20                  25                  30


Trp Val Ala His Lys Thr Leu Thr Ser Ser Ala Thr Ser Pro Ile Ser 
        35                  40                  45


His Leu Pro Gly Ser Leu Met Glu Pro Val Glu Lys Glu Arg Ala Ser 
    50                  55                  60


Thr Pro Tyr Ile Glu Lys Gln Val Asp His Leu Ile Lys Lys Ala Thr 
65                  70                  75                  80


Arg Pro Glu Glu Leu Leu Glu Leu Leu Gly Gly Ser His Asp Leu Asp 
                85                  90                  95


Ser Asn Gln Ala Ala Met Val Leu Ile Arg Leu Ser His Leu Leu Ser 
            100                 105                 110


Glu Lys Pro Glu Asp Lys Gly Leu Leu Ile Gln Asp Ala His Cys Met 
        115                 120                 125


Leu Trp Ala Ser Pro Arg Pro Pro Arg Ser Cys Ser Arg Trp Ser Arg 
    130                 135                 140


Arg Ser Ala Gly Ala Cys Gly Ser Ser Ser Thr Ser Thr Trp Pro Ser 
145                 150                 155                 160


Trp Gln Ser Pro Val Pro Pro Ser His Arg Ser Ser Thr Arg Arg Ser 
                165                 170                 175


Cys Trp Leu Ser Cys Ser His Thr Trp Lys Gly Val Gly Gln Lys Leu 
            180                 185                 190


Lys Ile Pro Thr His 
        195


<210>  3796
<211>  600
<212>  DNA
<213>  Homo sapiens

<400>  3796
tcgtttccgc cggcgctccg agtgacgtag ggaagcgcgc cgcgcacctc atggttccgg     60

ggacagttag ggcggcggat ggaggtcagc ggtggtgctc gctgcggttt ggaatcactt    120

gctaggagtc ttgtctctct gccacccagg acatcatggc agctcacctg gtaaagcgat    180

gcacgtgcct cctgagagaa gctgctcgtc aggcccctgc catggctcca gttggccgac    240

tgagacttgc ctgggtagcc cataagactc tgacttcctc agccacctca cccatttccc    300

acctcccagg ttccttgatg gagccggtgg agaaggaacg agcatctact ccctacatag    360

agaagcaggt ggaccacctc atcaagaagg ccacaaggcc agaggagctc ctggagctac    420

ttggtggcag tcacgacttg gacagcaatc aagcagcaat ggtacttatc cggctctctc    480

acttgctgtc tgagaagcca gaagataaag gcttgctcat acaggatgcc cactttcatc    540

aacttctctg tctgctcaac agtcagattg cctcggtctg gcatggtacc ctctcgaagc    600


<210>  3797
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  3797

Met Ala Ala His Leu Val Lys Arg Cys Thr Cys Leu Leu Arg Glu Ala 
1               5                   10                  15


Ala Arg Gln Ala Pro Ala Met Ala Pro Val Gly Arg Leu Arg Leu Ala 
            20                  25                  30


Trp Val Ala His Lys Thr Leu Thr Ser Ser Ala Thr Ser Pro Ile Ser 
        35                  40                  45


His Leu Pro Gly Ser Leu Met Glu Pro Val Glu Lys Glu Arg Ala Ser 
    50                  55                  60


Thr Pro Tyr Ile Glu Lys Gln Val Asp His Leu Ile Lys Lys Ala Thr 
65                  70                  75                  80


Arg Pro Glu Glu Leu Leu Glu Leu Leu Gly Gly Ser His Asp Leu Asp 
                85                  90                  95


Ser Asn Gln Ala Ala Met Val Leu Ile Arg Leu Ser His Leu Leu Ser 
            100                 105                 110


Glu Lys Pro Glu Asp Lys Gly Leu Leu Ile Gln Asp Ala His Phe His 
        115                 120                 125


Gln Leu Leu Cys Leu Leu Asn Ser Gln Ile Ala Ser Val Trp His Gly 
    130                 135                 140


Thr Leu Ser 
145


<210>  3798
<211>  594
<212>  DNA
<213>  Homo sapiens

<400>  3798
tcgtttccgc cggcgctccg agtgacgtag ggaagcgcgc cgcgcacctc atggttccgg     60

ggacagttag ggcggcggat ggaggtcagc ggtggtgctc gctgcggttt ggaatcactt    120

gctaggagtc ttgtctctct gccacccagg acatcatggc agctcacctg gtaaagcgat    180

gcacgtgcct cctgagagaa gctgctcgtc aggcccctgc catggctcca gttggccgac    240

tgagacttgc ctgggtagcc cataagactc tgacttcctc agccacctca cccatttccc    300

acctcccagg ttccttgatg gagccggtgg agaaggaacg agcatctact ccctacatag    360

agaagcaggt ggaccacctc atcaagaagg ccacaaggcc agaggagctc ctggagctac    420

ttggtggcag tcacgacttg gacagcaatc aagcagcaat ggtacttatc cggctctctc    480

acttgctgtc tgagaagcca gaagataaag gcttgctcat acaggatgcc cactttcatc    540

aacttctctg tctgctcaac agtcagaaag tcttatgatg caagactgaa catt          594


<210>  3799
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  3799

Met Ala Ala His Leu Val Lys Arg Cys Thr Cys Leu Leu Arg Glu Ala 
1               5                   10                  15


Ala Arg Gln Ala Pro Ala Met Ala Pro Val Gly Arg Leu Arg Leu Ala 
            20                  25                  30


Trp Val Ala His Lys Thr Leu Thr Ser Ser Ala Thr Ser Pro Ile Ser 
        35                  40                  45


His Leu Pro Gly Ser Leu Met Glu Pro Val Glu Lys Glu Arg Ala Ser 
    50                  55                  60


Thr Pro Tyr Ile Glu Lys Gln Val Asp His Leu Ile Lys Lys Ala Thr 
65                  70                  75                  80


Arg Pro Glu Glu Leu Leu Glu Leu Leu Gly Gly Ser His Asp Leu Asp 
                85                  90                  95


Ser Asn Gln Ala Ala Met Val Leu Ile Arg Leu Ser His Leu Leu Ser 
            100                 105                 110


Glu Lys Pro Glu Asp Lys Gly Leu Leu Ile Gln Asp Ala His Phe His 
        115                 120                 125


Gln Leu Leu Cys Leu Leu Asn Ser Gln Lys Val Leu 
    130                 135                 140


<210>  3800
<211>  769
<212>  DNA
<213>  Homo sapiens

<400>  3800
agttagggcg gcggatggag gtcagcggtg gtgctcgctg cgtaggtctt gtggcacggg     60

gagaaggggc ggctgatcgt gggtttcgag tgcacaacac aggcgtggct gggaaggtcc    120

tgggatgcgg tggaactggg gagcaggctg ggacgcggtg ggatgccgtg ggcctggccg    180

tctgctcgtt ccgtgctggc ttgccagtgc gcacgcttcc tctctagccc gcgcggccag    240

gcctggaaga cgccgcccct gttgaccgtc catgacccca gcgagccagt tttcgtgact    300

tagtgcaagg tttggaatca cttgctagga gtcttgtctc tctgccaccc aggacatcat    360

ggcagctcac ctggtaaagc gatgcacgtg cctcctgaga gaagctgctc gtcaggcccc    420

tgccatggct ccagttggcc gactgagact tgcctgggta gcccataaga ctctgacttc    480

ctcagccacc tcacccattt cccacctccc aggttccttg atggagccgg tggagaagga    540

acgagcatct actccctaca tagagaagca ggtggaccac ctcatcaaga aggccacaag    600

gccagaggag ctcctggagc tacttggtgg cagtcacgac ttggacagca atcaagcagc    660

aatggtactt atccggctct ctcacttgct gtctgagaag ccagaagata aaggcttgct    720

catacaggat gcccactttc atcaacttct ctgtctgctc aacagtcag                769


<210>  3801
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  3801

Met Ala Ala His Leu Val Lys Arg Cys Thr Cys Leu Leu Arg Glu Ala 
1               5                   10                  15


Ala Arg Gln Ala Pro Ala Met Ala Pro Val Gly Arg Leu Arg Leu Ala 
            20                  25                  30


Trp Val Ala His Lys Thr Leu Thr Ser Ser Ala Thr Ser Pro Ile Ser 
        35                  40                  45


His Leu Pro Gly Ser Leu Met Glu Pro Val Glu Lys Glu Arg Ala Ser 
    50                  55                  60


Thr Pro Tyr Ile Glu Lys Gln Val Asp His Leu Ile Lys Lys Ala Thr 
65                  70                  75                  80


Arg Pro Glu Glu Leu Leu Glu Leu Leu Gly Gly Ser His Asp Leu Asp 
                85                  90                  95


Ser Asn Gln Ala Ala Met Val Leu Ile Arg Leu Ser His Leu Leu Ser 
            100                 105                 110


Glu Lys Pro Glu Asp Lys Gly Leu Leu Ile Gln Asp Ala His Phe His 
        115                 120                 125


Gln Leu Leu Cys Leu Leu Asn Ser 
    130                 135


<210>  3802
<211>  649
<212>  DNA
<213>  Homo sapiens

<400>  3802
atggttccgg ggacagttag ggcggcggat ggaggtcagc ggtggtgctc gctgctggag     60

ttagactaag ctttttacag ctgctttaat cccctcatat aaaaagaaaa tgtgctggcc    120

atataccaag ttccaggaag tggagaaaga tcaaacgtac attctgcttt ggcagaaatg    180

aggcctaggg tttggaatca cttgctagga gtcttgtctc tctgccaccc aggacatcat    240

ggcagctcac ctggtaaagc gatgcacgtg cctcctgaga gaagctgctc gtcaggcccc    300

tgccatggct ccagttggcc gactgagact tgcctgggta gcccataaga ctctgacttc    360

ctcagccacc tcacccattt cccacctccc aggttccttg atggagccgg tggagaagga    420

acgagcatct actccctaca tagagaagca ggtggaccac ctcatcaaga aggccacaag    480

gccagaggag ctcctggagc tacttggtgg cagtcacgac ttggacagca atcaagcagc    540

aatggtactt atccggctct ctcacttgct gtctgagaag ccagaagata aaggcttgct    600

catacaggat gcccactttc atcaacttct ctgtctgctc aacagtcag                649


<210>  3803
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  3803

Met Arg Pro Arg Val Trp Asn His Leu Leu Gly Val Leu Ser Leu Cys 
1               5                   10                  15


His Pro Gly His His Gly Ser Ser Pro Gly Lys Ala Met His Val Pro 
            20                  25                  30


Pro Glu Arg Ser Cys Ser Ser Gly Pro Cys His Gly Ser Ser Trp Pro 
        35                  40                  45


Thr Glu Thr Cys Leu Gly Ser Pro 
    50                  55


<210>  3804
<211>  579
<212>  DNA
<213>  Homo sapiens

<400>  3804
ctgcttcctc tcccgagggc tgtcctggca gaggcccccc tcgctctttc tggcgggaac     60

agggccagca gcgaaagaac agtcgcagag ggaaagcggg aaagagatgg gggaaagtgt    120

gtgtgtgtga gtgtgtgctt gtgtgcatgt gtgtgcgtgt gtgtgtcaag gaaaaaagct    180

cgcagtccag cagcccgggc ctgggaggct tgtgagccgg gcctttcgta attgtcccct    240

ccccgcggcc ccctccccca ggcctccccc ctctcccgcc ctcccgcccg ccctctctcc    300

ctccctcttt ccctcacagc cgacgaggca acaattaggc tttggggata aaacgaggtg    360

cggagagcgg gctggggcat ttctccccga gatggcgggt ctgacggcgg cggccccgcg    420

gcccggagtc ctcctgctcc tgctgtccat cctccacccc tctcggcctg gaggggtccc    480

tggggccatt cctggtggag ttcctggagg agtcttttat ccaggtaacg tacatgaaac    540

ttccacacac ccaggtcatg cggatgatgc tgatgtcca                           579


<210>  3805
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  3805

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Asn Val His 
        35                  40                  45


Glu Thr Ser Thr His Pro Gly His Ala Asp Asp Ala Asp 
    50                  55                  60


<210>  3806
<211>  932
<212>  DNA
<213>  Homo sapiens

<400>  3806
gaaagaacag tcgcagaggg aaagcgggaa agagatgggg gaaagtgtgt gtgtgtgagt     60

gtgtgcttgt gtgcatgtgt gtgcgtgtgt gtgtcaagga aaaaagctcg cagtccagca    120

gcccgggcct gggaggcttg tgagccgggc ctttcgtaat tgtcccctcc ccgcggcccc    180

ctcccccagg cctcccccct ctcccgccct cccgcccgcc ctctctccct ccctctttcc    240

ctcacagccg acgaggcaac aattaggctt tggggataaa acgaggtgcg gagagcgggc    300

tggggcattt ctccccgaga tggcgggtct gacggcggcg gccccgcggc ccggagtcct    360

cctgctcctg ctgtccatcc tccacccctc tcggcctgga ggggtccctg gggccattcc    420

tggtggagtt cctggaggag tcttttatcc aggggctggt ctcggagccc ttggaggagg    480

agcgctgggg cctggaggca aacctcttaa gccaggtaag acccaaggcc tcggagcatt    540

gagagacagc gagggagctg gggagggagg agcctaccca gctgggaatg ggacaaggaa    600

actaggaaca ggacaaggaa gccaacgggc aggaggaagg agggaggtgt ggacaccgat    660

tagcctccca aggatgagta ggccggggcc aggtcccagg gcttccagga acaagaggct    720

ggaagcagct ccatgtcctc cctgtgtgag ggcgtctagc atctacccta catgtgcatg    780

tgtgttcacc cagctgtcca gagactcctc tctgcaaagg agaggctgtt agaggcaaca    840

tcagggattg ctccggttcc agtggcctcc aagccttaca tgaccctcgg gagctcagac    900

acagatcctc agccccagac ttcccctgag tg                                  932


<210>  3807
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  3807

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60


Pro Gly Lys Thr Gln Gly Leu Gly Ala Leu Arg Asp Ser Glu Gly Ala 
65                  70                  75                  80


Gly Glu Gly Gly Ala Tyr Pro Ala Gly Asn Gly Thr Arg Lys Leu Gly 
                85                  90                  95


Thr Gly Gln Gly Ser Gln Arg Ala Gly Gly Arg Arg Glu Val Trp Thr 
            100                 105                 110


Pro Ile Ser Leu Pro Arg Met Ser Arg Pro Gly Pro Gly Pro Arg Ala 
        115                 120                 125


Ser Arg Asn Lys Arg Leu Glu Ala Ala Pro Cys Pro Pro Cys Val Arg 
    130                 135                 140


Ala Ser Ser Ile Tyr Pro Thr Cys Ala Cys Val Phe Thr Gln Leu Ser 
145                 150                 155                 160


Arg Asp Ser Ser Leu Gln Arg Arg Gly Cys 
                165                 170


<210>  3808
<211>  887
<212>  DNA
<213>  Homo sapiens

<400>  3808
gaaagaacag tcgcagaggg aaagcgggaa agagatgggg gaaagtgtgt gtgtgtgagt     60

gtgtgcttgt gtgcatgtgt gtgcgtgtgt gtgtcaagga aaaaagctcg cagtccagca    120

gcccgggcct gggaggcttg tgagccgggc ctttcgtaat tgtcccctcc ccgcggcccc    180

ctcccccagg cctcccccct ctcccgccct cccgcccgcc ctctctccct ccctctttcc    240

ctcacagccg acgaggcaac aattaggctt tggggataaa acgaggtgcg gagagcgggc    300

tggggcattt ctccccgaga tggcgggtct gacggcggcg gccccgcggc ccggagtcct    360

cctgctcctg ctgtccatcc tccacccctc tcggcctgga ggggtccctg gggccattcc    420

tggtggagtt cctggaggag tcttttatcc aggggctggt ctcggagccc ttggaggagg    480

agcgctgggg cctggaggca aacctcttaa gccagttccc ggagggcttg cgggtgctgg    540

ccttggggca gggctcggcg ccttccccgc agttaccttt ccgggggctc tggtgcctgg    600

tggagtggct gacgctgctg cagcctataa agctgctaag gctggcgctg ggcttggtgg    660

tgtcccagga gttggtggct taggagtgtc tgcaggtacg atggctatcc ccgaactccc    720

tgggtcaaag ttgcaggcct gggtggagcc aactctgatg cagccccttc tgtgccaggt    780

gcggtggttc ctcagcctgg agccggagtg aagcctggga aagtgccggg tcagtgcgga    840

atccctgggg ctggaggaca gagggcaggg aggggcagag ggcaggg                  887


<210>  3809
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  3809

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Thr Met 
        115                 120                 125


Ala Ile Pro Glu Leu Pro Gly Ser Lys Leu Gln Ala Trp Val Glu Pro 
    130                 135                 140


Thr Leu Met Gln Pro Leu Leu Cys Gln Val Arg Trp Phe Leu Ser Leu 
145                 150                 155                 160


Glu Pro Glu 



<210>  3810
<211>  862
<212>  DNA
<213>  Homo sapiens

<400>  3810
gaaagaacag tcgcagaggg aaagcgggaa agagatgggg gaaagtgtgt gtgtgtgagt     60

gtgtgcttgt gtgcatgtgt gtgcgtgtgt gtgtcaagga aaaaagctcg cagtccagca    120

gcccgggcct gggaggcttg tgagccgggc ctttcgtaat tgtcccctcc ccgcggcccc    180

ctcccccagg cctcccccct ctcccgccct cccgcccgcc ctctctccct ccctctttcc    240

ctcacagccg acgaggcaac aattaggctt tggggataaa acgaggtgcg gagagcgggc    300

tggggcattt ctccccgaga tggcgggtct gacggcggcg gccccgcggc ccggagtcct    360

cctgctcctg ctgtccatcc tccacccctc tcggcctgga ggggtccctg gggccattcc    420

tggtggagtt cctggaggag tcttttatcc aggggctggt ctcggagccc ttggaggagg    480

agcgctgggg cctggaggca aacctcttaa gccagttccc ggagggcttg cgggtgctgg    540

ccttggggca gggctcggcg ccttccccgc agttaccttt ccgggggctc tggtgcctgg    600

tggagtggct gacgctgctg cagcctataa agctgctaag gctggcgctg ggcttggtgg    660

tgtcccagga gttggtggct taggagtgtc tgcaggtgcg gtggttcctc agcctggagc    720

cggagtgaag cctgggaaag tgccgggtca gtgcggaatc cctggggctg gaggacagag    780

ggcagggagg ggcagagggc agggaggaac agagccctct ccatgccact gcacttgggg    840

aggaagggca gggcctggct tc                                             862


<210>  3811
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  3811

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val 
        115                 120                 125


Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly Gln 
    130                 135                 140


Cys Gly Ile Pro Gly Ala Gly Gly Gln Arg Ala Gly Arg Gly Arg Gly 
145                 150                 155                 160


Gln Gly Gly Thr Glu Pro Ser Pro Cys His Cys Thr Trp Gly Gly Arg 
                165                 170                 175


Ala Gly Pro Gly 
            180


<210>  3812
<211>  839
<212>  DNA
<213>  Homo sapiens

<400>  3812
gaaagaacag tcgcagaggg aaagcgggaa agagatgggg gaaagtgtgt gtgtgtgagt     60

gtgtgcttgt gtgcatgtgt gtgcgtgtgt gtgtcaagga aaaaagctcg cagtccagca    120

gcccgggcct gggaggcttg tgagccgggc ctttcgtaat tgtcccctcc ccgcggcccc    180

ctcccccagg cctcccccct ctcccgccct cccgcccgcc ctctctccct ccctctttcc    240

ctcacagccg acgaggcaac aattaggctt tggggataaa acgaggtgcg gagagcgggc    300

tggggcattt ctccccgaga tggcgggtct gacggcggcg gccccgcggc ccggagtcct    360

cctgctcctg ctgtccatcc tccacccctc tcggcctgga ggggtccctg gggccattcc    420

tggtggagtt cctggaggag tcttttatcc aggggctggt ctcggagccc ttggaggagg    480

agcgctgggg cctggaggca aacctcttaa gccagttccc ggagggcttg cgggtgctgg    540

ccttggggca gggctcggcg ccttccccgc agttaccttt ccgggggctc tggtgcctgg    600

tggagtggct gacgctgctg cagcctataa agctgctaag gctggcgctg ggcttggtgg    660

tgtcccagga gttggtggct taggagtgtc tgcaggtgcg gtggttcctc agcctggagc    720

cggagtgaag cctgggaaag tgccgggtgt ggggctgcca ggtgtatacc caggtggcgt    780

gctcccaggt gagagcaagg agggaaacag ggactctata ggaagaaagc agccaggac     839


<210>  3813
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  3813

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val 
        115                 120                 125


Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly Val 
    130                 135                 140


Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro Gly Glu Ser Lys 
145                 150                 155                 160


Glu Gly Asn Arg Asp Ser Ile Gly Arg Lys Gln Pro 
                165                 170


<210>  3814
<211>  892
<212>  DNA
<213>  Homo sapiens

<400>  3814
gaaagaacag tcgcagaggg aaagcgggaa agagatgggg gaaagtgtgt gtgtgtgagt     60

gtgtgcttgt gtgcatgtgt gtgcgtgtgt gtgtcaagga aaaaagctcg cagtccagca    120

gcccgggcct gggaggcttg tgagccgggc ctttcgtaat tgtcccctcc ccgcggcccc    180

ctcccccagg cctcccccct ctcccgccct cccgcccgcc ctctctccct ccctctttcc    240

ctcacagccg acgaggcaac aattaggctt tggggataaa acgaggtgcg gagagcgggc    300

tggggcattt ctccccgaga tggcgggtct gacggcggcg gccccgcggc ccggagtcct    360

cctgctcctg ctgtccatcc tccacccctc tcggcctgga ggggtccctg gggccattcc    420

tggtggagtt cctggaggag tcttttatcc aggggctggt ctcggagccc ttggaggagg    480

agcgctgggg cctggaggca aacctcttaa gccagttccc ggagggcttg cgggtgctgg    540

ccttggggca gggctcggcg ccttccccgc agttaccttt ccgggggctc tggtgcctgg    600

tggagtggct gacgctgctg cagcctataa agctgctaag gctggcgctg ggcttggtgg    660

tgtcccagga gttggtggct taggagtgtc tgcaggtgcg gtggttcctc agcctggagc    720

cggagtgaag cctgggaaag tgccgggtgt ggggctgcca ggtgtatacc caggtggcgt    780

gctcccagga gctcggttcc ccggtgtggg ggtgctccct ggagttccca ctggagcagg    840

agttaagccc aaggctccag gtatgcagct gtctggacag agggctgatg gc            892


<210>  3815
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  3815

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val 
        115                 120                 125


Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly Val 
    130                 135                 140


Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro Gly Ala Arg Phe 
145                 150                 155                 160


Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly Ala Gly Val Lys 
                165                 170                 175


Pro Lys Ala Pro Gly Met Gln Leu Ser Gly Gln Arg Ala Asp 
            180                 185                 190


<210>  3816
<211>  801
<212>  DNA
<213>  Homo sapiens

<400>  3816
gaaagaacag tcgcagaggg aaagcgggaa agagatgggg gaaagtgtgt gtgtgtgagt     60

gtgtgcttgt gtgcatgtgt gtgcgtgtgt gtgtcaagga aaaaagctcg cagtccagca    120

gcccgggcct gggaggcttg tgagccgggc ctttcgtaat tgtcccctcc ccgcggcccc    180

ctcccccagg cctcccccct ctcccgccct cccgcccgcc ctctctccct ccctctttcc    240

ctcacagccg acgaggcaac aattaggctt tggggataaa acgaggtgcg gagagcgggc    300

tggggcattt ctccccgaga tggcgggtct gacggcggcg gccccgcggc ccggagtcct    360

cctgctcctg ctgtccatcc tccacccctc tcggcctgga ggggtccctg gggccattcc    420

tggtggagtt cctggaggag tcttttatcc aggggctggt ctcggagccc ttggaggagg    480

agcgctgggg cctggaggca aacctcttaa gccagttccc ggagggcttg cgggtgctgg    540

ccttggggca gggctcggcg ccttccccgc agttaccttt ccgggggctc tggtgcctgg    600

tggagtggct gacgctgctg cagcctataa agctgctaag gctggcgctg ggcttggtgg    660

tgtcccagga gttggtggct taggagtgtc tgcaggtgcg gtggttcctc agcctggagc    720

cggagtgaag cctgggaaag tgccgggtca gtgcggtctc tccaggggtt gtgtcaccag    780

aagcagctgc taaggcagct g                                              801


<210>  3817
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  3817

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val 
        115                 120                 125


Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly Gln 
    130                 135                 140


Cys Gly Leu Ser Arg Gly Cys Val Thr Arg Ser Ser Cys 
145                 150                 155


<210>  3818
<211>  2782
<212>  DNA
<213>  Homo sapiens

<400>  3818
gaaagaacag tcgcagaggg aaagcgggaa agagatgggg gaaagtgtgt gtgtgtgagt     60

gtgtgcttgt gtgcatgtgt gtgcgtgtgt gtgtcaagga aaaaagctcg cagtccagca    120

gcccgggcct gggaggcttg tgagccgggc ctttcgtaat tgtcccctcc ccgcggcccc    180

ctcccccagg cctcccccct ctcccgccct cccgcccgcc ctctctccct ccctctttcc    240

ctcacagccg acgaggcaac aattaggctt tggggataaa acgaggtgcg gagagcgggc    300

tggggcattt ctccccgaga tggcgggtct gacggcggcg gccccgcggc ccggagtcct    360

cctgctcctg ctgtccatcc tccacccctc tcggcctgga ggggtccctg gggccattcc    420

tggtggagtt cctggaggag tcttttatcc aggggctggt ctcggagccc ttggaggagg    480

agcgctgggg cctggaggca aacctcttaa gccagttccc ggagggcttg cgggtgctgg    540

ccttggggca gggctcggcg ccttccccgc agttaccttt ccgggggctc tggtgcctgg    600

tggagtggct gacgctgctg cagcctataa agctgctaag gctggcgctg ggcttggtgg    660

tgtcccagga gttggtggct taggagtgtc tgcaggtgcg gtggttcctc agcctggagc    720

cggagtgaag cctgggaaag tgccgggtgt ggggctgcca ggtgtatacc caggtggcgt    780

gctcccagga gctcggttcc ccggtgtggg ggtgctccct ggagttccca ctggagcagg    840

agttaagccc aaggctccag gtgtaggtgg agcttttgct ggaatcccag gagttggacc    900

ctttggggga ccgcaacctg gagtcccact ggggtatccc atcaaggccc ccaagctgcc    960

tggtggctat ggactgccct acaccacagg gaaactgccc tatggctatg ggcccggagg   1020

agtggctggt gcagcgggca aggctggtta cccaacaggg acaggggttg gcccccaggc   1080

agcagcagca gcggcagcta aagcagcagc aaagttcggt gctggagcag ccggagtcct   1140

ccctggtgtt ggaggggctg gtgttcctgg cgtgcctggg gcaattcctg gaattggagg   1200

catcgcaggc gttgggactc cagctgcagc tgcagctgca gcagcagccg ctaaggcagc   1260

caagtatgga gctgctgcag gcttagtgcc tggtgggcca ggctttggcc cgggagtagt   1320

tggtgtccca ggagctggcg ttccaggtgt tggtgtccca ggagctggga ttccagttgt   1380

cccaggtgct gggatcccag gtgctgcggt tccaggggtt gtgtcaccag aagcagctgc   1440

taaggcagct gcaaaggcag ccaaatacgg ggccaggccc ggagtcggag ttggaggcat   1500

tcctacttac ggggttggag ctgggggctt tcccggcttt ggtgtcggag tcggaggtat   1560

ccctggagtc gcaggtgtcc ctggtgtcgg aggtgttccc ggagtcggag gtgtcccggg   1620

agttggcatt tcccccgaag ctcaggcagc agctgccgcc aaggctgcca agtacggagt   1680

ggggacccca gcagctgcag ctgctaaagc agccgccaaa gccgcccagt ttgggttagt   1740

tcctggtgtc ggcgtggctc ctggagttgg cgtggctcct ggtgtcggtg tggctcctgg   1800

agttggcttg gctcctggag ttggcgtggc tcctggagtt ggtgtggctc ctggcgttgg   1860

cgtggctccc ggcattggcc ctggtggagt tgcagctgca gcaaaatccg ctgccaaggt   1920

ggctgccaaa gcccagctcc gagctgcagc tgggcttggt gctggcatcc ctggacttgg   1980

agttggtgtc ggcgtccctg gacttggagt tggtgctggt gttcctggac ttggagttgg   2040

tgctggtgtt cctggcttcg gggcaggtgc agatgaggga gttaggcgga gcctgtcccc   2100

tgagctcagg gaaggagatc cctcctcctc tcagcacctc cccagcaccc cctcatcacc   2160

cagggtacct ggagccctgg ctgccgctaa agcagccaaa tatggagcag cagtgcctgg   2220

ggtccttgga gggctcgggg ctctcggtgg agtaggcatc ccaggcggtg tggtgggagc   2280

cggacccgcc gccgccgctg ccgcagccaa agctgctgcc aaagccgccc agtttggcct   2340

agtgggagcc gctgggctcg gaggactcgg agtcggaggg cttggagttc caggtgttgg   2400

gggccttgga ggtatacctc cagctgcagc cgctaaagca gctaaatacg gtgctgctgg   2460

ccttggaggt gtcctagggg gtgccgggca gttcccactt ggaggagtgg cagcaagacc   2520

tggcttcgga ttgtctccca ttttcccagg tggggcctgc ctggggaaag cttgtggccg   2580

gaagagaaaa tgagcttcct aggacccctg actcacgacc tcatcaacgt tggtgctact   2640

gcttggtgga gaatgtaaac ccttttatac cccccatccc tccctcggtc cactgaactt   2700

cagagcagtt cccattcctg ccccgcccat ctttttgtgt ctcgctgtga tagatcaata   2760

aatattttat tttttgtcct gg                                            2782


<210>  3819
<211>  757
<212>  PRT
<213>  Homo sapiens

<400>  3819

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val 
        115                 120                 125


Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly Val 
    130                 135                 140


Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro Gly Ala Arg Phe 
145                 150                 155                 160


Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly Ala Gly Val Lys 
                165                 170                 175


Pro Lys Ala Pro Gly Val Gly Gly Ala Phe Ala Gly Ile Pro Gly Val 
            180                 185                 190


Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile 
        195                 200                 205


Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu Pro Tyr Thr Thr Gly 
    210                 215                 220


Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala Gly 
225                 230                 235                 240


Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly Pro Gln Ala Ala Ala 
                245                 250                 255


Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe Gly Ala Gly Ala Ala Gly 
            260                 265                 270


Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro Gly Val Pro Gly Ala 
        275                 280                 285


Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly Thr Pro Ala Ala Ala 
    290                 295                 300


Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Ala 
305                 310                 315                 320


Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro Gly Val Val Gly Val 
                325                 330                 335


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Ile Pro 
            340                 345                 350


Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala Val Pro Gly Val Val 
        355                 360                 365


Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Lys Tyr Gly 
    370                 375                 380


Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro Thr Tyr Gly Val Gly 
385                 390                 395                 400


Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val Gly Gly Ile Pro Gly 
                405                 410                 415


Val Ala Gly Val Pro Gly Val Gly Gly Val Pro Gly Val Gly Gly Val 
            420                 425                 430


Pro Gly Val Gly Ile Ser Pro Glu Ala Gln Ala Ala Ala Ala Ala Lys 
        435                 440                 445


Ala Ala Lys Tyr Gly Val Gly Thr Pro Ala Ala Ala Ala Ala Lys Ala 
    450                 455                 460


Ala Ala Lys Ala Ala Gln Phe Gly Leu Val Pro Gly Val Gly Val Ala 
465                 470                 475                 480


Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly 
                485                 490                 495


Leu Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly 
            500                 505                 510


Val Gly Val Ala Pro Gly Ile Gly Pro Gly Gly Val Ala Ala Ala Ala 
        515                 520                 525


Lys Ser Ala Ala Lys Val Ala Ala Lys Ala Gln Leu Arg Ala Ala Ala 
    530                 535                 540


Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly Val Gly Val Gly Val Pro 
545                 550                 555                 560


Gly Leu Gly Val Gly Ala Gly Val Pro Gly Leu Gly Val Gly Ala Gly 
                565                 570                 575


Val Pro Gly Phe Gly Ala Gly Ala Asp Glu Gly Val Arg Arg Ser Leu 
            580                 585                 590


Ser Pro Glu Leu Arg Glu Gly Asp Pro Ser Ser Ser Gln His Leu Pro 
        595                 600                 605


Ser Thr Pro Ser Ser Pro Arg Val Pro Gly Ala Leu Ala Ala Ala Lys 
    610                 615                 620


Ala Ala Lys Tyr Gly Ala Ala Val Pro Gly Val Leu Gly Gly Leu Gly 
625                 630                 635                 640


Ala Leu Gly Gly Val Gly Ile Pro Gly Gly Val Val Gly Ala Gly Pro 
                645                 650                 655


Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe 
            660                 665                 670


Gly Leu Val Gly Ala Ala Gly Leu Gly Gly Leu Gly Val Gly Gly Leu 
        675                 680                 685


Gly Val Pro Gly Val Gly Gly Leu Gly Gly Ile Pro Pro Ala Ala Ala 
    690                 695                 700


Ala Lys Ala Ala Lys Tyr Gly Ala Ala Gly Leu Gly Gly Val Leu Gly 
705                 710                 715                 720


Gly Ala Gly Gln Phe Pro Leu Gly Gly Val Ala Ala Arg Pro Gly Phe 
                725                 730                 735


Gly Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys Ala Cys 
            740                 745                 750


Gly Arg Lys Arg Lys 
        755


<210>  3820
<211>  3228
<212>  DNA
<213>  Homo sapiens

<400>  3820
gaaagaacag tcgcagaggg aaagcgggaa agagatgggg gaaagtgtgt gtgtgtgagt     60

gtgtgcttgt gtgcatgtgt gtgcgtgtgt gtgtcaagga aaaaagctcg cagtccagca    120

gcccgggcct gggaggcttg tgagccgggc ctttcgtaat tgtcccctcc ccgcggcccc    180

ctcccccagg cctcccccct ctcccgccct cccgcccgcc ctctctccct ccctctttcc    240

ctcacagccg acgaggcaac aattaggctt tggggataaa acgaggtgcg gagagcgggc    300

tggggcattt ctccccgaga tggcgggtct gacggcggcg gccccgcggc ccggagtcct    360

cctgctcctg ctgtccatcc tccacccctc tcggcctgga ggggtccctg gggccattcc    420

tggtggagtt cctggaggag tcttttatcc aggggctggt ctcggagccc ttggaggagg    480

agcgctgggg cctggaggca aacctcttaa gccagggctc ggcgccttcc ccgcagttac    540

ctttccgggg gctctggtgc ctggtggagt ggctgacgct gctgcagcct ataaagctgc    600

taaggctggc gctgggcttg gtggtgtccc aggagttggt ggcttaggag tgtctgcagg    660

tgcggtggtt cctcagcctg gagccggagt gaagcctggg aaagtgccgg gtgtggggct    720

gccaggtgta tacccaggtg gcgtgctccc aggagctcgg ttccccggtg tgggggtgct    780

ccctggagtt cccactggag caggagttaa gcccaaggct ccaggagttg gaccctttgg    840

gggaccgcaa cctggagtcc cactggggta tcccatcaag gcccccaagc tgcctggcta    900

tgggcccgga ggagtggctg gtgcagcggg caaggctggt tacccaacag ggacaggggt    960

tggcccccag gcagcagcag cagcggcagc taaagcagca gcaaagttcg gtgctggagc   1020

agccggagtc ctccctggtg ttggaggggc tggtgttcct ggcgtgcctg gggcaattcc   1080

tggaattgga ggcatcgcag gcgttgggac tccagctgca gctgcagctg cagcagcagc   1140

cgctaaggca gccaagtatg gagctgctgc aggcttagtg cctggtgggc caggctttgg   1200

cccgggagta gttggtgtcc caggagctgg cgttccaggt gttggtgtcc caggagctgg   1260

gattccagtt gtcccaggtg ctgggatccc aggtgctgcg gttccagggg ttgtgtcacc   1320

agaagcagct gctaaggcag ctgcaaaggc agccaaatac ggggccaggc ccggagtcgg   1380

agttggaggc attcctactt acggggttgg agctgggggc tttcccggct ttggtgtcgg   1440

agtcggagcc gaagctcagg cagcagctgc cgccaaggct gccaagtacg ggttagttcc   1500

tggtgtcggc gtggctcctg gagttggcgt ggctcctggt gtcggtgtgg ctcctggagt   1560

tggcttggct cctggagttg gcgtggctcc tggagttggt gtggctcctg gcgttggcgt   1620

ggctcccggc attggccctg gtggagttgc agctgcagca aaatccgctg ccaaggtggc   1680

tgccaaagcc cagctccgag ctgcagctgg gcttggtgct ggcatccctg gacttggagt   1740

tggtgtcggc gtccctggac ttggagttgg tgctggtgtt cctggacttg gagttggtgc   1800

tggtgttcct ggcttcgggg cagtacctgg agccctggct gccgctaaag cagccaaata   1860

tggagcagca gtgcctgggg tccttggagg gctcggggct ctcggtggag taggcatccc   1920

aggcggtgtg gtgggagccg gacccgccgc cgccgctgcc gcagccaaag ctgctgccaa   1980

agccgcccag tttggcctag tgggagccgc tgggctcgga ggactcggag tcggagggct   2040

tggagttcca ggtgttgggg gccttggagg tatacctcca gctgcagccg ctaaagcagc   2100

taaatacggt gctgctggcc ttggaggtgt cctagggggt gccgggcagt tcccacttgg   2160

aggagtggca gcaagacctg gcttcggatt gtctcccatt ttcccaggtg gggcctgcct   2220

ggggaaagct tgtggccgga agagaaaatg agcttcctag gacccctgac tcacgacctc   2280

atcaacgttg gtgctactgc ttggtggaga atgtaaaccc tttgtaaccc catcccatgc   2340

ccctccgact ccccacccca ggagggaacg ggcaggccgg gcggccttgc agatccacag   2400

ggcaaggaaa caagagggga gcggccaagt gccccgacca ggaggccccc tacttcagag   2460

gcaagggcca tgtggtcctg gccccccacc ccatcccttc ccacctagga gctccccctc   2520

cacacagcct ccatctccag gggaacttgg tgctacacgc tggtgctctt atcttcctgg   2580

ggggagggag gagggaaggg tggcccctcg gggaaccccc tacctggggc tcctctaaag   2640

atggtgcaga cacttcctgg gcagtcccag ctccccctgc ccaccaggac ccaccgttgg   2700

ctgccatcca gttggtaccc aagcacctga agcctcaaag ctggattcgc tctagcatcc   2760

ctcctctcct gggtccactt ggccgtctcc tccccaccga tcgctgttcc ccacatctgg   2820

ggcgcttttg ggttggaaaa ccaccccaca ctgggaatag ccaccttgcc cttgtagaat   2880

ccatccgccc atccgtccat tcatccatcg gtccgtccat ccatgtcccc agttgaccgc   2940

ccggcaccac tagctggctg ggtgcaccca ccatcaacct ggttgacctg tcatggccgc   3000

ctgtgccctg cctccacccc catcctacac tcccccaggg cgtgcggggc tgtgcagact   3060

ggggtgccag gcatctcctc cccacccggg gtgtccccac atgcagtact gtataccccc   3120

catccctccc tcggtccact gaacttcaga gcagttccca ttcctgcccc gcccatcttt   3180

ttgtgtctcg ctgtgataga tcaataaata ttttattttt tgtcctgg                3228


<210>  3821
<211>  643
<212>  PRT
<213>  Homo sapiens

<400>  3821

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60


Pro Gly Leu Gly Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val 
65                  70                  75                  80


Pro Gly Gly Val Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala 
                85                  90                  95


Gly Ala Gly Leu Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser 
            100                 105                 110


Ala Gly Ala Val Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys 
        115                 120                 125


Val Pro Gly Val Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro 
    130                 135                 140


Gly Ala Arg Phe Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly 
145                 150                 155                 160


Ala Gly Val Lys Pro Lys Ala Pro Gly Val Gly Pro Phe Gly Gly Pro 
                165                 170                 175


Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile Lys Ala Pro Lys Leu Pro 
            180                 185                 190


Gly Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala Gly Lys Ala Gly Tyr 
        195                 200                 205


Pro Thr Gly Thr Gly Val Gly Pro Gln Ala Ala Ala Ala Ala Ala Ala 
    210                 215                 220


Lys Ala Ala Ala Lys Phe Gly Ala Gly Ala Ala Gly Val Leu Pro Gly 
225                 230                 235                 240


Val Gly Gly Ala Gly Val Pro Gly Val Pro Gly Ala Ile Pro Gly Ile 
                245                 250                 255


Gly Gly Ile Ala Gly Val Gly Thr Pro Ala Ala Ala Ala Ala Ala Ala 
            260                 265                 270


Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Ala Gly Leu Val Pro 
        275                 280                 285


Gly Gly Pro Gly Phe Gly Pro Gly Val Val Gly Val Pro Gly Ala Gly 
    290                 295                 300


Val Pro Gly Val Gly Val Pro Gly Ala Gly Ile Pro Val Val Pro Gly 
305                 310                 315                 320


Ala Gly Ile Pro Gly Ala Ala Val Pro Gly Val Val Ser Pro Glu Ala 
                325                 330                 335


Ala Ala Lys Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Arg Pro Gly 
            340                 345                 350


Val Gly Val Gly Gly Ile Pro Thr Tyr Gly Val Gly Ala Gly Gly Phe 
        355                 360                 365


Pro Gly Phe Gly Val Gly Val Gly Ala Glu Ala Gln Ala Ala Ala Ala 
    370                 375                 380


Ala Lys Ala Ala Lys Tyr Gly Leu Val Pro Gly Val Gly Val Ala Pro 
385                 390                 395                 400


Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Leu 
                405                 410                 415


Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val 
            420                 425                 430


Gly Val Ala Pro Gly Ile Gly Pro Gly Gly Val Ala Ala Ala Ala Lys 
        435                 440                 445


Ser Ala Ala Lys Val Ala Ala Lys Ala Gln Leu Arg Ala Ala Ala Gly 
    450                 455                 460


Leu Gly Ala Gly Ile Pro Gly Leu Gly Val Gly Val Gly Val Pro Gly 
465                 470                 475                 480


Leu Gly Val Gly Ala Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val 
                485                 490                 495


Pro Gly Phe Gly Ala Val Pro Gly Ala Leu Ala Ala Ala Lys Ala Ala 
            500                 505                 510


Lys Tyr Gly Ala Ala Val Pro Gly Val Leu Gly Gly Leu Gly Ala Leu 
        515                 520                 525


Gly Gly Val Gly Ile Pro Gly Gly Val Val Gly Ala Gly Pro Ala Ala 
    530                 535                 540


Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe Gly Leu 
545                 550                 555                 560


Val Gly Ala Ala Gly Leu Gly Gly Leu Gly Val Gly Gly Leu Gly Val 
                565                 570                 575


Pro Gly Val Gly Gly Leu Gly Gly Ile Pro Pro Ala Ala Ala Ala Lys 
            580                 585                 590


Ala Ala Lys Tyr Gly Ala Ala Gly Leu Gly Gly Val Leu Gly Gly Ala 
        595                 600                 605


Gly Gln Phe Pro Leu Gly Gly Val Ala Ala Arg Pro Gly Phe Gly Leu 
    610                 615                 620


Ser Pro Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys Ala Cys Gly Arg 
625                 630                 635                 640


Lys Arg Lys 



<210>  3822
<211>  3471
<212>  DNA
<213>  Homo sapiens

<400>  3822
gaaagaacag tcgcagaggg aaagcgggaa agagatgggg gaaagtgtgt gtgtgtgagt     60

gtgtgcttgt gtgcatgtgt gtgcgtgtgt gtgtcaagga aaaaagctcg cagtccagca    120

gcccgggcct gggaggcttg tgagccgggc ctttcgtaat tgtcccctcc ccgcggcccc    180

ctcccccagg cctcccccct ctcccgccct cccgcccgcc ctctctccct ccctctttcc    240

ctcacagccg acgaggcaac aattaggctt tggggataaa acgaggtgcg gagagcgggc    300

tggggcattt ctccccgaga tggcgggtct gacggcggcg gccccgcggc ccggagtcct    360

cctgctcctg ctgtccatcc tccacccctc tcggcctgga ggggtccctg gggccattcc    420

tggtggagtt cctggaggag tcttttatcc aggggctggt ctcggagccc ttggaggagg    480

agcgctgggg cctggaggca aacctcttaa gccagttccc ggagggcttg cgggtgctgg    540

ccttggggca gggctcggcg ccttccccgc agttaccttt ccgggggctc tggtgcctgg    600

tggagtggct gacgctgctg cagcctataa agctgctaag gctggcgctg ggcttggtgg    660

tgtcccagga gttggtggct taggagtgtc tgcaggtgcg gtggttcctc agcctggagc    720

cggagtgaag cctgggaaag tgccgggtgt ggggctgcca ggtgtatacc caggtggcgt    780

gctcccagga gctcggttcc ccggtgtggg ggtgctccct ggagttccca ctggagcagg    840

agttaagccc aaggctccag gtgtaggtgg agcttttgct ggaatcccag gagttggacc    900

ctttggggga ccgcaacctg gagtcccact ggggtatccc atcaaggccc ccaagctgcc    960

tggtggctat ggactgccct acaccacagg gaaactgccc tatggctatg ggcccggagg   1020

agtggctggt gcagcgggca aggctggtta cccaacaggg acaggggttg gcccccaggc   1080

agcagcagca gcggcagcta aagcagcagc aaagttcggt gctggagcag ccggagtcct   1140

ccctggtgtt ggaggggctg gtgttcctgg cgtgcctggg gcaattcctg gaattggagg   1200

catcgcaggc gttgggactc cagctgcagc tgcagctgca gcagcagccg ctaaggcagc   1260

caagtatgga gctgctgcag gcttagtgcc tggtgggcca ggctttggcc cgggagtagt   1320

tggtgtccca ggagctggcg ttccaggtgt tggtgtccca ggagctggga ttccagttgt   1380

cccaggtgct gggatcccag gtgctgcggt tccaggggtt gtgtcaccag aagcagctgc   1440

taaggcagct gcaaaggcag ccaaatacgg ggccaggccc ggagtcggag ttggaggcat   1500

tcctacttac ggggttggag ctgggggctt tcccggcttt ggtgtcggag tcggaggtat   1560

ccctggagtc gcaggtgtcc ctggtgtcgg aggtgttccc ggagtcggag gtgtcccggg   1620

agttggcatt tcccccgaag ctcaggcagc agctgccgcc aaggctgcca agtacggagt   1680

ggggacccca gcagctgcag ctgctaaagc agccgccaaa gccgcccagt ttgggttagt   1740

tcctggtgtc ggcgtggctc ctggagttgg cgtggctcct ggtgtcggtg tggctcctgg   1800

agttggcttg gctcctggag ttggcgtggc tcctggagtt ggtgtggctc ctggcgttgg   1860

cgtggctccc ggcattggcc ctggtggagt tgcagctgca gcaaaatccg ctgccaaggt   1920

ggctgccaaa gcccagctcc gagctgcagc tgggcttggt gctggcatcc ctggacttgg   1980

agttggtgtc ggcgtccctg gacttggagt tggtgctggt gttcctggac ttggagttgg   2040

tgctggtgtt cctggcttcg gggcagtacc tggagccctg gctgccgcta aagcagccaa   2100

atatggagca gcagtgcctg gggtccttgg agggctcggg gctctcggtg gagtaggcat   2160

cccaggcggt gtggtgggag ccggacccgc cgccgccgct gccgcagcca aagctgctgc   2220

caaagccgcc cagtttggcc tagtgggagc cgctgggctc ggaggactcg gagtcggagg   2280

gcttggagtt ccaggtgttg ggggccttgg aggtatacct ccagctgcag ccgctaaagc   2340

agctaaatac ggtgctgctg gccttggagg tgtcctaggg ggtgccgggc agttcccact   2400

tggaggagtg gcagcaagac ctggcttcgg attgtctccc attttcccag gtggggcctg   2460

cctggggaaa gcttgtggcc ggaagagaaa atgagcttcc taggacccct gactcacgac   2520

ctcatcaacg ttggtgctac tgcttggtgg agaatgtaaa ccctttgtaa ccccatccca   2580

tgcccctccg actccccacc ccaggaggga acgggcaggc cgggcggcct tgcagatcca   2640

cagggcaagg aaacaagagg ggagcggcca agtgccccga ccaggaggcc ccctacttca   2700

gaggcaaggg ccatgtggtc ctggcccccc accccatccc ttcccaccta ggagctcccc   2760

ctccacacag cctccatctc caggggaact tggtgctaca cgctggtgct cttatcttcc   2820

tggggggagg gaggagggaa gggtggcccc tcggggaacc ccctacctgg ggctcctcta   2880

aagatggtgc agacacttcc tgggcagtcc cagctccccc tgcccaccag gacccaccgt   2940

tggctgccat ccagttggta cccaagcacc tgaagcctca aagctggatt cgctctagca   3000

tccctcctct cctgggtcca cttggccgtc tcctccccac cgatcgctgt tccccacatc   3060

tggggcgctt ttgggttgga aaaccacccc acactgggaa tagccacctt gcccttgtag   3120

aatccatccg cccatccgtc cattcatcca tcggtccgtc catccatgtc cccagttgac   3180

cgcccggcac cactagctgg ctgggtgcac ccaccatcaa cctggttgac ctgtcatggc   3240

cgcctgtgcc ctgcctccac ccccatccta cactccccca gggcgtgcgg ggctgtgcag   3300

actggggtgc caggcatctc ctccccaccc ggggtgtccc cacatgcagt actgtatacc   3360

ccccatccct ccctcggtcc actgaacttc agagcagttc ccattcctgc cccgcccatc   3420

tttttgtgtc tcgctgtgat agatcaataa atattttatt ttttgtcctg g            3471


<210>  3823
<211>  724
<212>  PRT
<213>  Homo sapiens

<400>  3823

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val 
        115                 120                 125


Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly Val 
    130                 135                 140


Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro Gly Ala Arg Phe 
145                 150                 155                 160


Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly Ala Gly Val Lys 
                165                 170                 175


Pro Lys Ala Pro Gly Val Gly Gly Ala Phe Ala Gly Ile Pro Gly Val 
            180                 185                 190


Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile 
        195                 200                 205


Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu Pro Tyr Thr Thr Gly 
    210                 215                 220


Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala Gly 
225                 230                 235                 240


Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly Pro Gln Ala Ala Ala 
                245                 250                 255


Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe Gly Ala Gly Ala Ala Gly 
            260                 265                 270


Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro Gly Val Pro Gly Ala 
        275                 280                 285


Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly Thr Pro Ala Ala Ala 
    290                 295                 300


Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Ala 
305                 310                 315                 320


Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro Gly Val Val Gly Val 
                325                 330                 335


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Ile Pro 
            340                 345                 350


Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala Val Pro Gly Val Val 
        355                 360                 365


Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Lys Tyr Gly 
    370                 375                 380


Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro Thr Tyr Gly Val Gly 
385                 390                 395                 400


Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val Gly Gly Ile Pro Gly 
                405                 410                 415


Val Ala Gly Val Pro Gly Val Gly Gly Val Pro Gly Val Gly Gly Val 
            420                 425                 430


Pro Gly Val Gly Ile Ser Pro Glu Ala Gln Ala Ala Ala Ala Ala Lys 
        435                 440                 445


Ala Ala Lys Tyr Gly Val Gly Thr Pro Ala Ala Ala Ala Ala Lys Ala 
    450                 455                 460


Ala Ala Lys Ala Ala Gln Phe Gly Leu Val Pro Gly Val Gly Val Ala 
465                 470                 475                 480


Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly 
                485                 490                 495


Leu Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly 
            500                 505                 510


Val Gly Val Ala Pro Gly Ile Gly Pro Gly Gly Val Ala Ala Ala Ala 
        515                 520                 525


Lys Ser Ala Ala Lys Val Ala Ala Lys Ala Gln Leu Arg Ala Ala Ala 
    530                 535                 540


Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly Val Gly Val Gly Val Pro 
545                 550                 555                 560


Gly Leu Gly Val Gly Ala Gly Val Pro Gly Leu Gly Val Gly Ala Gly 
                565                 570                 575


Val Pro Gly Phe Gly Ala Val Pro Gly Ala Leu Ala Ala Ala Lys Ala 
            580                 585                 590


Ala Lys Tyr Gly Ala Ala Val Pro Gly Val Leu Gly Gly Leu Gly Ala 
        595                 600                 605


Leu Gly Gly Val Gly Ile Pro Gly Gly Val Val Gly Ala Gly Pro Ala 
    610                 615                 620


Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe Gly 
625                 630                 635                 640


Leu Val Gly Ala Ala Gly Leu Gly Gly Leu Gly Val Gly Gly Leu Gly 
                645                 650                 655


Val Pro Gly Val Gly Gly Leu Gly Gly Ile Pro Pro Ala Ala Ala Ala 
            660                 665                 670


Lys Ala Ala Lys Tyr Gly Ala Ala Gly Leu Gly Gly Val Leu Gly Gly 
        675                 680                 685


Ala Gly Gln Phe Pro Leu Gly Gly Val Ala Ala Arg Pro Gly Phe Gly 
    690                 695                 700


Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys Ala Cys Gly 
705                 710                 715                 720


Arg Lys Arg Lys 



<210>  3824
<211>  1666
<212>  DNA
<213>  Homo sapiens

<400>  3824
gaaagaacag tcgcagaggg aaagcgggaa agagatgggg gaaagtgtgt gtgtgtgagt     60

gtgtgcttgt gtgcatgtgt gtgcgtgtgt gtgtcaagga aaaaagctcg cagtccagca    120

gcccgggcct gggaggcttg tgagccgggc ctttcgtaat tgtcccctcc ccgcggcccc    180

ctcccccagg cctcccccct ctcccgccct cccgcccgcc ctctctccct ccctctttcc    240

ctcacagccg acgaggcaac aattaggctt tggggataaa acgaggtgcg gagagcgggc    300

tggggcattt ctccccgaga tggcgggtct gacggcggcg gccccgcggc ccggagtcct    360

cctgctcctg ctgtccatcc tccacccctc tcggcctgga ggggtccctg gggccattcc    420

tggtggagtt cctggaggag tcttttatcc aggggctggt ctcggagccc ttggaggagg    480

agcgctgggg cctggaggca aacctcttaa gccagttccc ggagggcttg cgggtgctgg    540

ccttggggca gggcagccgc taaggcagcc aagtatggag ctgctgcagg cttagtgcct    600

ggtgggccag gctttggccc gggagtagtt ggtgtcccag gagctggcgt tccaggtgtt    660

ggtgtcccag gagctgggat tccagttgtc ccaggtgctg ggatcccagg tgctgcggtt    720

ccaggggttg tgtcaccaga agcagctgct aaggcagctg caaaggcagc caaatacggg    780

gccaggcccg gagtcggagt tggaggcatt cctacttacg gggttggagc tgggggcttt    840

cccggctttg gtgtcggagt cggaggtatc cctggagtcg caggtgtccc tggtgtcgga    900

ggtgttcccg gagtcggagg tgtcccggga gttggcattt cccccgaagc tcaggcagca    960

gctgccgcca aggctgccaa gtacgggtta gttcctggtg tcggcgtggc tcctggagtt   1020

ggcgtggctc ctggtgtcgg tgtggctcct ggagttggct tggctcctgg agttggcgtg   1080

gctcctggag ttggtgtggc tcctggcgtt ggcgtggctc ccggcattgg ccctggtgga   1140

gttgcagctg cagcaaaatc cgctgccaag gtggctgcca aagcccagct ccgagctgca   1200

gctgggcttg gtgctggcat ccctggactt ggagttggtg tcggcgtccc tggacttgga   1260

gttggtgctg gtgttcctgg acttggagtt ggtgctggtg ttcctggctt cggggcagta   1320

cctggagccc tggctgccgc taaagcagcc aaatatggag cagcagtgcc tggggtcctt   1380

ggagggctcg gggctctcgg tggagtaggc atcaacctgg ttgacctgtc atggccgcct   1440

gtgccctgcc tccaccccca tcctacactc ccccagggcg tgcggggctg tgcagactgg   1500

ggtgccaggc atctcctccc cacccggggt gtccccacat gcagtactgt atacccccca   1560

tccctccctc ggtccactga acttcagagc agttcccatt cctgccccgc ccatcttttt   1620

gtgtctcgct gtgatagatc aataaatatt ttattttttg tcctgg                  1666


<210>  3825
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  3825

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Gln Pro 
65                  70                  75                  80


Leu Arg Gln Pro Ser Met Glu Leu Leu Gln Ala 
                85                  90


<210>  3826
<211>  2859
<212>  DNA
<213>  Homo sapiens

<400>  3826
gaaagaacag tcgcagaggg aaagcgggaa agagatgggg gaaagtgtgt gtgtgtgagt     60

gtgtgcttgt gtgcatgtgt gtgcgtgtgt gtgtcaagga aaaaagctcg cagtccagca    120

gcccgggcct gggaggcttg tgagccgggc ctttcgtaat tgtcccctcc ccgcggcccc    180

ctcccccagg cctcccccct ctcccgccct cccgcccgcc ctctctccct ccctctttcc    240

ctcacagccg acgaggcaac aattaggctt tggggataaa acgaggtgcg gagagcgggc    300

tggggcattt ctccccgaga tggcgggtct gacggcggcg gccccgcggc ccggagtcct    360

cctgctcctg ctgtccatcc tccacccctc tcggcctgga ggggtccctg gggccattcc    420

tggtggagtt cctggaggag tcttttatcc aggggctggt ctcggagccc ttggaggagg    480

agcgctgggg cctggaggca aacctcttaa gccagttccc ggagggcttg cgggtgctgg    540

ccttggggca gggctcggcg ccttccccgc agttaccttt ccgggggctc tggtgcctgg    600

tggagtggct gacgctgctg cagcctataa agctgctaag gctggcgctg ggcttggtgg    660

tgtcccagga gttggtggct taggagtgtc tgcaggtgcg gtggttcctc agcctggagc    720

cggagtgaag cctgggaaag tgccgggtgt ggggctgcca ggtgtatacc caggtggcgt    780

gctcccagga gctcggttcc ccggtgtggg ggtgctccct ggagttccca ctggagcagg    840

agttaagccc aaggctccag gtgtaggtgg agcttttgct ggaatcccag gagttggacc    900

ctttggggga ccgcaacctg gagtcccact ggggtatccc atcaaggccc ccaagctgcc    960

tggtggctat ggactgccct acaccacagg gaaactgccc tatggctatg ggcccggagg   1020

agtggctggt gcagcgggca aggctggtta cccaacaggg acaggggttg gcccccaggg   1080

tgctggagca gccggagtcc tccctggtgt tggaggggct ggtgttcctg gcgtgcctgg   1140

ggcaattcct ggaattggag gcatcgcagg cgttgggact ccagctgcag ctgcagctgc   1200

agcagcagcc gctaaggcag ccaagtatgg agctgctgca ggcttagtgc ctggtgggcc   1260

aggctttggc ccgggagtat tggtgctggt gttcctggac ttggagttgg tgctggtgtt   1320

cctggcttcg gggcagtacc tggagccctg gctgccgcta aagcagccaa atatggagca   1380

gcagtgcctg gggtccttgg agggctcggg gctctcggtg gagtaggcat cccaggcggt   1440

gtggtggggg cctagtggga gccgctgggc tcggaggact cggagtcgga gggcttggag   1500

ttccaggtgt tgggggcctt ggaggtatac ctccagctgc agccgctaaa gcagctaaat   1560

acggagtggc agcaagacct ggcttcggat tgtctcccat tttcccaggt ggggcctgcc   1620

tggggaaagc ttgtggccgg aagagaaaat gagcttccta ggacccctga ctcacgacct   1680

catcaacgtt ggtgctactg cttggtggag aatgtaaacc ctttgtaacc ccatcccatg   1740

cccctccgac tccccacccc aggagggaac gggcaggccg ggcggccttg cagatccaca   1800

gggcaaggaa acaagagggg agcggccaag tgccccgacc aggaggcccc ctacttcaga   1860

ggcaagggcc atgtggtcct ggccccccac cccatccctt cccacctagg agctccccct   1920

ccacacagcc tccatctcca ggggaacttg gtgctacacg ctggtgctct tatcttcctg   1980

gggggaggga ggagggaagg gtggcccctc ggggaacccc ctacctgggg ctcctctaaa   2040

gatggtgcag acacttcctg ggcagtccca gctccccctg cccaccagga cccaccgttg   2100

gctgccatcc agttggtacc caagcacctg aagcctcaaa gctggattcg ctctagcatc   2160

cctcctctcc tgggtccact tggccgtctc ctccccaccg atcgctgttc cccacatctg   2220

gggcgctttt gggttggaaa accaccccac actgggaata gccaccttgc ccttgtagaa   2280

tccatccgcc catccgtcca ttcatccatc ggtccgtcca tccatgtccc cagttgaccg   2340

cccggcacca ctagctggct gggtgcaccc accatcaacc tggttgacct gtcatggccg   2400

cctgtgccct gcctccaccc ccatcctaca ctcccccagg gcgtgcgggg ctgtgcagac   2460

tggggtgcca ggcatctcct ccccacccgg ggtgtcccca catgcagtac tgtatacccc   2520

ccatccctcc ctcggtccac tgaacttcag agcagttccc attcctgccc cgcccatctt   2580

tttgtgtctc gctgtgatag atcaataaat attttatttt ttgtcctgga tatttgggga   2640

ttatttttga ttgttgatat tctcttttgg ttttattgtt gtggttcatt gaaaaaaaaa   2700

gataattttt ttttctgatc cggggagctg tatccccagt agaaaaaaca ttttaatcac   2760

tctaatataa ctctggatga aacacacctt tttttttaat aagaaaagag aattaactgc   2820

ttcagaaatg actaataaat gaaaaacctt taaaggaaa                          2859


<210>  3827
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  3827

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val 
        115                 120                 125


Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly Val 
    130                 135                 140


Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro Gly Ala Arg Phe 
145                 150                 155                 160


Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly Ala Gly Val Lys 
                165                 170                 175


Pro Lys Ala Pro Gly Val Gly Gly Ala Phe Ala Gly Ile Pro Gly Val 
            180                 185                 190


Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile 
        195                 200                 205


Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu Pro Tyr Thr Thr Gly 
    210                 215                 220


Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala Gly 
225                 230                 235                 240


Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly Pro Gln Gly Ala Gly 
                245                 250                 255


Ala Ala Gly Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro Gly Val 
            260                 265                 270


Pro Gly Ala Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly Thr Pro 
        275                 280                 285


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly 
    290                 295                 300


Ala Ala Ala Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro Gly Val 
305                 310                 315                 320


Leu Val Leu Val Phe Leu Asp Leu Glu Leu Val Leu Val Phe Leu Ala 
                325                 330                 335


Ser Gly Gln Tyr Leu Glu Pro Trp Leu Pro Leu Lys Gln Pro Asn Met 
            340                 345                 350


Glu Gln Gln Cys Leu Gly Ser Leu Glu Gly Ser Gly Leu Ser Val Glu 
        355                 360                 365


<210>  3828
<211>  3458
<212>  DNA
<213>  Homo sapiens

<400>  3828
gaaagaacag tcgcagaggg aaagcgggaa agagatgggg gaaagtgtgt gtgtgtgagt     60

gtgtgcttgt gtgcatgtgt gtgcgtgtgt gtgtcaagga aaaaagctcg cagtccagca    120

gcccgggcct gggaggcttg tgagccgggc ctttcgtaat tgtcccctcc ccgcggcccc    180

ctcccccagg cctcccccct ctcccgccct cccgcccgcc ctctctccct ccctctttcc    240

ctcacagccg acgaggcaac aattaggctt tggggataaa acgaggtgcg gagagcgggc    300

tggggcattt ctccccgaga tggcgggtct gacggcggcg gccccgcggc ccggagtcct    360

cctgctcctg ctgtccatcc tccacccctc tcggcctgga ggggtccctg gggccattcc    420

tggtggagtt cctggaggag tcttttatcc aggggctggt ctcggagccc ttggaggagg    480

agcgctgggg cctggaggca aacctcttaa gccagggctc ggcgccttcc ccgcagttac    540

ctttccgggg gctctggtgc ctggtggagt ggctgacgct gctgcagcct ataaagctgc    600

taaggctggc gctgggcttg gtggtgtccc aggagttggt ggcttaggag tgtctgcagg    660

tgcggtggtt cctcagcctg gagccggagt gaagcctggg aaagtgccgg gtgtggggct    720

gccaggtgta tacccaggtg gcgtgctccc aggagctcgg ttccccggtg tgggggtgct    780

ccctggagtt cccactggag caggagttaa gcccaaggct ccaggagttg gaccctttgg    840

gggaccgcaa cctggagtcc cactggggta tcccatcaag gcccccaagc tgcctggcta    900

tgggcccgga ggagtggctg gtgcagcggg caaggctggt tacccaacag ggacaggggt    960

tggcccccag gcagcagcag cagcggcagc taaagcagca gcaaagttcg gtgctggagc   1020

agccggagtc ctccctggtg ttggaggggc tggtgttcct ggcgtgcctg gggcaattcc   1080

tggaattgga ggcatcgcag gcgttgggac tccagctgca gctgcagctg cagcagcagc   1140

cgctaaggca gccaagtatg gagctgctgc aggcttagtg cctggtgggc caggctttgg   1200

cccgggagta gttggtgtcc caggagctgg cgttccaggt gttggtgtcc caggagctgg   1260

gattccagtt gtcccaggtg ctgggatccc aggtgctgcg gttccagggg ttgtgtcacc   1320

agaagcagct gctaaggcag ctgcaaaggc agccaaatac ggggccaggc ccggagtcgg   1380

agttggaggc attcctactt acggggttgg agctgggggc tttcccggct ttggtgtcgg   1440

agtcggagcc gaagctcagg cagcagctgc cgccaaggct gccaagtacg ggttagttcc   1500

tggtgtcggc gtggctcctg gagttggcgt ggctcctggt gtcggtgtgg ctcctggagt   1560

tggcttggct cctggagttg gcgtggctcc tggagttggt gtggctcctg gcgttggcgt   1620

ggctcccggc attggccctg gtggagttgc agctgcagca aaatccgctg ccaaggtggc   1680

tgccaaagcc cagctccgag ctgcagctgg gcttggtgct ggcatccctg gacttggagt   1740

tggtgtcggc gtccctggac ttggagttgg tgctggtgtt cctggacttg gagttggtgc   1800

tggtgttcct ggcttcgggg cagtacctgg agccctggct gccgctaaag cagccaaata   1860

tggagcagca gtgcctgggg tccttggagg gctcggggct ctcggtggag taggcatccc   1920

aggcggtgtg gtgggagccg gacccgccgc cgccgctgcc gcagccaaag ctgctgccaa   1980

agccgcccag tttggcctag tgggagccgc tgggctcgga ggactcggag tcggagggct   2040

tggagttcca ggtgttgggg gccttggagg tatacctcca gctgcagccg ctaaagcagc   2100

taaatacggt gctgctggcc ttggaggtgt cctagggggt gccgggcagt tcccacttgg   2160

aggagtggca gcaagacctg gcttcggatt gtctcccatt ttcccaggtg gggcctgcct   2220

ggggaaagct tgtggccgga agagaaaatg agcttcctag gacccctgac tcacgacctc   2280

atcaacgttg gtgctactgc ttggtggaga atgtaaaccc tttgtaaccc catcccatgc   2340

ccctccgact ccccacccca ggagggaacg ggcaggccgg gcggccttgc agatccacag   2400

ggcaaggaaa caagagggga gcggccaagt gccccgacca ggaggccccc tacttcagag   2460

gcaagggcca tgtggtcctg gccccccacc ccatcccttc ccacctagga gctccccctc   2520

cacacagcct ccatctccag gggaacttgg tgctacacgc tggtgctctt atcttcctgg   2580

ggggagggag gagggaaggg tggcccctcg gggaaccccc tacctggggc tcctctaaag   2640

atggtgcaga cacttcctgg gcagtcccag ctccccctgc ccaccaggac ccaccgttgg   2700

ctgccatcca gttggtaccc aagcacctga agcctcaaag ctggattcgc tctagcatcc   2760

ctcctctcct gggtccactt ggccgtctcc tccccaccga tcgctgttcc ccacatctgg   2820

ggcgcttttg ggttggaaaa ccaccccaca ctgggaatag ccaccttgcc cttgtagaat   2880

ccatccgccc atccgtccat tcatccatcg gtccgtccat ccatgtcccc agttgaccgc   2940

ccggcaccac tagctggctg ggtgcaccca ccatcaacct ggttgacctg tcatggccgc   3000

ctgtgccctg cctccacccc catcctacac tcccccaggg cgtgcggggc tgtgcagact   3060

ggggtgccag gcatctcctc cccacccggg gtgtccccac atgcagtact gtataccccc   3120

catccctccc tcggtccact gaacttcaga gcagttccca ttcctgcccc gcccatcttt   3180

ttgtgtctcg ctgtgataga tcaataaata ttttattttt tgtcctggat atttggggat   3240

tatttttgat tgttgatatt ctcttttggt tttattgttg tggttcattg aaaaaaaaag   3300

ataatttttt tttctgatcc ggggagctgt atccccagta gaaaaaacat tttaatcact   3360

ctaatataac tctggatgaa acacaccttt ttttttaata agaaaagaga attaactgct   3420

tcagaaatga ctaataaatg aaaaaccttt aaaggaaa                           3458


<210>  3829
<211>  643
<212>  PRT
<213>  Homo sapiens

<400>  3829

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60


Pro Gly Leu Gly Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val 
65                  70                  75                  80


Pro Gly Gly Val Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala 
                85                  90                  95


Gly Ala Gly Leu Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser 
            100                 105                 110


Ala Gly Ala Val Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys 
        115                 120                 125


Val Pro Gly Val Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro 
    130                 135                 140


Gly Ala Arg Phe Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly 
145                 150                 155                 160


Ala Gly Val Lys Pro Lys Ala Pro Gly Val Gly Pro Phe Gly Gly Pro 
                165                 170                 175


Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile Lys Ala Pro Lys Leu Pro 
            180                 185                 190


Gly Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala Gly Lys Ala Gly Tyr 
        195                 200                 205


Pro Thr Gly Thr Gly Val Gly Pro Gln Ala Ala Ala Ala Ala Ala Ala 
    210                 215                 220


Lys Ala Ala Ala Lys Phe Gly Ala Gly Ala Ala Gly Val Leu Pro Gly 
225                 230                 235                 240


Val Gly Gly Ala Gly Val Pro Gly Val Pro Gly Ala Ile Pro Gly Ile 
                245                 250                 255


Gly Gly Ile Ala Gly Val Gly Thr Pro Ala Ala Ala Ala Ala Ala Ala 
            260                 265                 270


Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Ala Gly Leu Val Pro 
        275                 280                 285


Gly Gly Pro Gly Phe Gly Pro Gly Val Val Gly Val Pro Gly Ala Gly 
    290                 295                 300


Val Pro Gly Val Gly Val Pro Gly Ala Gly Ile Pro Val Val Pro Gly 
305                 310                 315                 320


Ala Gly Ile Pro Gly Ala Ala Val Pro Gly Val Val Ser Pro Glu Ala 
                325                 330                 335


Ala Ala Lys Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Arg Pro Gly 
            340                 345                 350


Val Gly Val Gly Gly Ile Pro Thr Tyr Gly Val Gly Ala Gly Gly Phe 
        355                 360                 365


Pro Gly Phe Gly Val Gly Val Gly Ala Glu Ala Gln Ala Ala Ala Ala 
    370                 375                 380


Ala Lys Ala Ala Lys Tyr Gly Leu Val Pro Gly Val Gly Val Ala Pro 
385                 390                 395                 400


Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Leu 
                405                 410                 415


Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val 
            420                 425                 430


Gly Val Ala Pro Gly Ile Gly Pro Gly Gly Val Ala Ala Ala Ala Lys 
        435                 440                 445


Ser Ala Ala Lys Val Ala Ala Lys Ala Gln Leu Arg Ala Ala Ala Gly 
    450                 455                 460


Leu Gly Ala Gly Ile Pro Gly Leu Gly Val Gly Val Gly Val Pro Gly 
465                 470                 475                 480


Leu Gly Val Gly Ala Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val 
                485                 490                 495


Pro Gly Phe Gly Ala Val Pro Gly Ala Leu Ala Ala Ala Lys Ala Ala 
            500                 505                 510


Lys Tyr Gly Ala Ala Val Pro Gly Val Leu Gly Gly Leu Gly Ala Leu 
        515                 520                 525


Gly Gly Val Gly Ile Pro Gly Gly Val Val Gly Ala Gly Pro Ala Ala 
    530                 535                 540


Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe Gly Leu 
545                 550                 555                 560


Val Gly Ala Ala Gly Leu Gly Gly Leu Gly Val Gly Gly Leu Gly Val 
                565                 570                 575


Pro Gly Val Gly Gly Leu Gly Gly Ile Pro Pro Ala Ala Ala Ala Lys 
            580                 585                 590


Ala Ala Lys Tyr Gly Ala Ala Gly Leu Gly Gly Val Leu Gly Gly Ala 
        595                 600                 605


Gly Gln Phe Pro Leu Gly Gly Val Ala Ala Arg Pro Gly Phe Gly Leu 
    610                 615                 620


Ser Pro Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys Ala Cys Gly Arg 
625                 630                 635                 640


Lys Arg Lys 



<210>  3830
<211>  3503
<212>  DNA
<213>  Homo sapiens

<400>  3830
gaaagaacag tcgcagaggg aaagcgggaa agagatgggg gaaagtgtgt gtgtgtgagt     60

gtgtgcttgt gtgcatgtgt gtgcgtgtgt gtgtcaagga aaaaagctcg cagtccagca    120

gcccgggcct gggaggcttg tgagccgggc ctttcgtaat tgtcccctcc ccgcggcccc    180

ctcccccagg cctcccccct ctcccgccct cccgcccgcc ctctctccct ccctctttcc    240

ctcacagccg acgaggcaac aattaggctt tggggataaa acgaggtgcg gagagcgggc    300

tggggcattt ctccccgaga tggcgggtct gacggcggcg gccccgcggc ccggagtcct    360

cctgctcctg ctgtccatcc tccacccctc tcggcctgga ggggtccctg gggccattcc    420

tggtggagtt cctggaggag tcttttatcc aggggctggt ctcggagccc ttggaggagg    480

agcgctgggg cctggaggca aacctcttaa gccagttccc ggagggcttg cgggtgctgg    540

ccttggggca gggctcggcg ccttccccgc agttaccttt ccgggggctc tggtgcctgg    600

tggagtggct gacgctgctg cagcctataa agctgctaag gctggcgctg ggcttggtgg    660

tgtcccagga gttggtggct taggagtgtc tgcaggtgcg gtggttcctc agcctggagc    720

cggagtgaag cctgggaaag tgccgggtgt ggggctgcca ggtgtatacc caggtggcgt    780

gctcccagga gctcggttcc ccggtgtggg ggtgctccct ggagttccca ctggagcagg    840

agttaagccc aaggctccag gtgtaggtgg agcttttgct ggaatcccag gagttggacc    900

ctttggggga ccgcaacctg gagtcccact ggggtatccc atcaaggccc ccaagctgcc    960

tggctatggg cccggaggag tggctggtgc agcgggcaag gctggttacc caacagggac   1020

aggggttggc ccccaggcag cagcagcagc ggcagctaaa gcagcagcaa agttcggtgc   1080

tggagcagcc ggagtcctcc ctggtgttgg aggggctggt gttcctggcg tgcctggggc   1140

aattcctgga attggaggca tcgcaggcgt tgggactcca gctgcagctg cagctgcagc   1200

agcagccgct aaggcagcca agtatggagc tgctgcaggc ttagtgcctg gtgggccagg   1260

ctttggcccg ggagtagttg gtgtcccagg agctggcgtt ccaggtgttg gtgtcccagg   1320

agctgggatt ccagttgtcc caggtgctgg gatcccaggt gctgcggttc caggggttgt   1380

gtcaccagaa gcagctgcta aggcagctgc aaaggcagcc aaatacgggg ccaggcccgg   1440

agtcggagtt ggaggcattc ctacttacgg ggttggagct gggggctttc ccggctttgg   1500

tgtcggagtc ggaggtatcc ctggagtcgc aggtgtccct ggtgtcggag gtgttcccgg   1560

agtcggaggt gtcccgggag ttggcatttc ccccgaagct caggcagcag ctgccgccaa   1620

ggctgccaag tacgggttag ttcctggtgt cggcgtggct cctggagttg gcgtggctcc   1680

tggtgtcggt gtggctcctg gagttggctt ggctcctgga gttggcgtgg ctcctggagt   1740

tggtgtggct cctggcgttg gcgtggctcc cggcattggc cctggtggag ttgcaggagc   1800

tgcagctggg cttggtgctg gcatccctgg acttggagtt ggtgtcggcg tccctggact   1860

tggagttggt gctggtgttc ctggacttgg agttggtgct ggtgttcctg gcttcggggc   1920

agtacctgga gccctggctg ccgctaaagc agccaaatat ggagcagcag tgcctggggt   1980

ccttggaggg ctcggggctc tcggtggagt aggcatccca ggcggtgtgg tgggagccgg   2040

acccgccgcc gccgctgccg cagccaaagc tgctgccaaa gccgcccagt ttggcctagt   2100

gggagccgct gggctcggag gactcggagt cggagggctt ggagttccag gtgttggggg   2160

ccttggaggt atacctccag ctgcagccgc taaagcagct aaatacggag tggcagcaag   2220

acctggcttc ggattgtctc ccattttccc aggtggggcc tgcctgggga aagcttgtgg   2280

ccggaagaga aaatgagctt cctaggaccc ctgactcacg acctcatcaa cgttggtgct   2340

actgcttggt ggagaatgta aaccctttgt aaccccatcc catgcccctc cgactcccca   2400

ccccaggagg gaacgggcag gccgggcggc cttgcagatc cacagggcaa ggaaacaaga   2460

ggggagcggc caagtgcccc gaccaggagg ccccctactt cagaggcaag ggccatgtgg   2520

tcctggcccc ccaccccatc ccttcccacc taggagctcc ccctccacac agcctccatc   2580

tccaggggaa cttggtgcta cacgctggtg ctcttatctt cctgggggga gggaggaggg   2640

aagggtggcc cctcggggaa ccccctacct ggggctcctc taaagatggt gcagacactt   2700

cctgggcagt cccagctccc cctgcccacc aggacccacc gttggctgcc atccagttgg   2760

tacccaagca cctgaagcct caaagctgga ttcgctctag catccctcct ctcctgggtc   2820

cacttggccg tctcctcccc accgatcgct gttccccaca tctggggcgc ttttgggttg   2880

gaaaaccacc ccacactggg aatagccacc ttgcccttgt agaatccatc cgcccatccg   2940

tccattcatc catcggtccg tccatccatg tccccagttg accgcccggc accactagct   3000

ggctgggtgc acccaccatc aacctggttg acctgtcatg gccgcctgtg ccctgcctcc   3060

acccccatcc tacactcccc cagggcgtgc ggggctgtgc agactggggt gccaggcatc   3120

tcctccccac ccggggtgtc cccacatgca gtactgtata ccccccatcc ctccctcggt   3180

ccactgaact tcagagcagt tcccattcct gccccgccca tctttttgtg tctcgctgtg   3240

atagatcaat aaatatttta ttttttgtcc tggatatttg gggattattt ttgattgttg   3300

atattctctt ttggttttat tgttgtggtt cattgaaaaa aaaagataat ttttttttct   3360

gatccgggga gctgtatccc cagtagaaaa aacattttaa tcactctaat ataactctgg   3420

atgaaacaca cctttttttt taataagaaa agagaattaa ctgcttcaga aatgactaat   3480

aaatgaaaaa cctttaaagg aaa                                           3503


<210>  3831
<211>  658
<212>  PRT
<213>  Homo sapiens

<400>  3831

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val 
        115                 120                 125


Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly Val 
    130                 135                 140


Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro Gly Ala Arg Phe 
145                 150                 155                 160


Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly Ala Gly Val Lys 
                165                 170                 175


Pro Lys Ala Pro Gly Val Gly Gly Ala Phe Ala Gly Ile Pro Gly Val 
            180                 185                 190


Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile 
        195                 200                 205


Lys Ala Pro Lys Leu Pro Gly Tyr Gly Pro Gly Gly Val Ala Gly Ala 
    210                 215                 220


Ala Gly Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly Pro Gln Ala 
225                 230                 235                 240


Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe Gly Ala Gly Ala 
                245                 250                 255


Ala Gly Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro Gly Val Pro 
            260                 265                 270


Gly Ala Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly Thr Pro Ala 
        275                 280                 285


Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala 
    290                 295                 300


Ala Ala Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro Gly Val Val 
305                 310                 315                 320


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly 
                325                 330                 335


Ile Pro Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala Val Pro Gly 
            340                 345                 350


Val Val Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Lys 
        355                 360                 365


Tyr Gly Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro Thr Tyr Gly 
    370                 375                 380


Val Gly Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val Gly Gly Ile 
385                 390                 395                 400


Pro Gly Val Ala Gly Val Pro Gly Val Gly Gly Val Pro Gly Val Gly 
                405                 410                 415


Gly Val Pro Gly Val Gly Ile Ser Pro Glu Ala Gln Ala Ala Ala Ala 
            420                 425                 430


Ala Lys Ala Ala Lys Tyr Gly Leu Val Pro Gly Val Gly Val Ala Pro 
        435                 440                 445


Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Leu 
    450                 455                 460


Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val 
465                 470                 475                 480


Gly Val Ala Pro Gly Ile Gly Pro Gly Gly Val Ala Gly Ala Ala Ala 
                485                 490                 495


Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly Val Gly Val Gly Val Pro 
            500                 505                 510


Gly Leu Gly Val Gly Ala Gly Val Pro Gly Leu Gly Val Gly Ala Gly 
        515                 520                 525


Val Pro Gly Phe Gly Ala Val Pro Gly Ala Leu Ala Ala Ala Lys Ala 
    530                 535                 540


Ala Lys Tyr Gly Ala Ala Val Pro Gly Val Leu Gly Gly Leu Gly Ala 
545                 550                 555                 560


Leu Gly Gly Val Gly Ile Pro Gly Gly Val Val Gly Ala Gly Pro Ala 
                565                 570                 575


Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe Gly 
            580                 585                 590


Leu Val Gly Ala Ala Gly Leu Gly Gly Leu Gly Val Gly Gly Leu Gly 
        595                 600                 605


Val Pro Gly Val Gly Gly Leu Gly Gly Ile Pro Pro Ala Ala Ala Ala 
    610                 615                 620


Lys Ala Ala Lys Tyr Gly Val Ala Ala Arg Pro Gly Phe Gly Leu Ser 
625                 630                 635                 640


Pro Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys Ala Cys Gly Arg Lys 
                645                 650                 655


Arg Lys 



<210>  3832
<211>  1896
<212>  DNA
<213>  Homo sapiens

<400>  3832
gaaagaacag tcgcagaggg aaagcgggaa agagatgggg gaaagtgtgt gtgtgtgagt     60

gtgtgcttgt gtgcatgtgt gtgcgtgtgt gtgtcaagga aaaaagctcg cagtccagca    120

gcccgggcct gggaggcttg tgagccgggc ctttcgtaat tgtcccctcc ccgcggcccc    180

ctcccccagg cctcccccct ctcccgccct cccgcccgcc ctctctccct ccctctttcc    240

ctcacagccg acgaggcaac aattaggctt tggggataaa acgaggtgcg gagagcgggc    300

tggggcattt ctccccgaga tggcgggtct gacggcggcg gccccgcggc ccggagtcct    360

cctgctcctg ctgtccatcc tccacccctc tcggcctgga ggggtccctg gggccattcc    420

tggtggagtt cctggaggag tcttttatcc aggggctggt ctcggagccc ttggaggagg    480

agcgctgggg cctggaggca aacctcttaa gccagttccc ggagggcttg cgggtgctgg    540

ccttggggca gggcagccgc taaggcagcc aagtatggag ctgctgcagg cttagtgcct    600

ggtgggccag gctttggccc gggagtagtt ggtgtcccag gagctggcgt tccaggtgtt    660

ggtgtcccag gagctgggat tccagttgtc ccaggtgctg ggatcccagg tgctgcggtt    720

ccaggggttg tgtcaccaga agcagctgct aaggcagctg caaaggcagc caaatacggg    780

gccaggcccg gagtcggagt tggaggcatt cctacttacg gggttggagc tgggggcttt    840

cccggctttg gtgtcggagt cggaggtatc cctggagtcg caggtgtccc tggtgtcgga    900

ggtgttcccg gagtcggagg tgtcccggga gttggcattt cccccgaagc tcaggcagca    960

gctgccgcca aggctgccaa gtacgggtta gttcctggtg tcggcgtggc tcctggagtt   1020

ggcgtggctc ctggtgtcgg tgtggctcct ggagttggct tggctcctgg agttggcgtg   1080

gctcctggag ttggtgtggc tcctggcgtt ggcgtggctc ccggcattgg ccctggtgga   1140

gttgcagctg cagcaaaatc cgctgccaag gtggctgcca aagcccagct ccgagctgca   1200

gctgggcttg gtgctggcat ccctggactt ggagttggtg tcggcgtccc tggacttgga   1260

gttggtgctg gtgttcctgg acttggagtt ggtgctggtg ttcctggctt cggggcagta   1320

cctggagccc tggctgccgc taaagcagcc aaatatggag cagcagtgcc tggggtcctt   1380

ggagggctcg gggctctcgg tggagtaggc atcaacctgg ttgacctgtc atggccgcct   1440

gtgccctgcc tccaccccca tcctacactc ccccagggcg tgcggggctg tgcagactgg   1500

ggtgccaggc atctcctccc cacccggggt gtccccacat gcagtactgt atacccccca   1560

tccctccctc ggtccactga acttcagagc agttcccatt cctgccccgc ccatcttttt   1620

gtgtctcgct gtgatagatc aataaatatt ttattttttg tcctggatat ttggggatta   1680

tttttgattg ttgatattct cttttggttt tattgttgtg gttcattgaa aaaaaaagat   1740

aatttttttt tctgatccgg ggagctgtat ccccagtaga aaaaacattt taatcactct   1800

aatataactc tggatgaaac acaccttttt ttttaataag aaaagagaat taactgcttc   1860

agaaatgact aataaatgaa aaacctttaa aggaaa                             1896


<210>  3833
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  3833

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Gln Pro 
65                  70                  75                  80


Leu Arg Gln Pro Ser Met Glu Leu Leu Gln Ala 
                85                  90


<210>  3834
<211>  3550
<212>  DNA
<213>  Homo sapiens

<400>  3834
gaaagaacag tcgcagaggg aaagcgggaa agagatgggg gaaagtgtgt gtgtgtgagt     60

gtgtgcttgt gtgcatgtgt gtgcgtgtgt gtgtcaagga aaaaagctcg cagtccagca    120

gcccgggcct gggaggcttg tgagccgggc ctttcgtaat tgtcccctcc ccgcggcccc    180

ctcccccagg cctcccccct ctcccgccct cccgcccgcc ctctctccct ccctctttcc    240

ctcacagccg acgaggcaac aattaggctt tggggataaa acgaggtgcg gagagcgggc    300

tggggcattt ctccccgaga tggcgggtct gacggcggcg gccccgcggc ccggagtcct    360

cctgctcctg ctgtccatcc tccacccctc tcggcctgga ggggtccctg gggccattcc    420

tggtggagtt cctggaggag tcttttatcc aggggctggt ctcggagccc ttggaggagg    480

agcgctgggg cctggaggca aacctcttaa gccagttccc ggagggcttg cgggtgctgg    540

ccttggggca gggctcggcg ccttccccgc agttaccttt ccgggggctc tggtgcctgg    600

tggagtggct gacgctgctg cagcctataa agctgctaag gctggcgctg ggcttggtgg    660

tgtcccagga gttggtggct taggagtgtc tgcaggtgcg gtggttcctc agcctggagc    720

cggagtgaag cctgggaaag tgccgggtgt ggggctgcca ggtgtatacc caggtggcgt    780

gctcccagga gctcggttcc ccggtgtggg ggtgctccct ggagttccca ctggagcagg    840

agttaagccc aaggctccag gtgtaggtgg agcttttgct ggaatcccag gagttggacc    900

ctttggggga ccgcaacctg gagtcccact ggggtatccc atcaaggccc ccaagctgcc    960

tggtggctat ggactgccct acaccacagg gaaactgccc tatggctatg ggcccggagg   1020

agtggctggt gcagcgggca aggctggtta cccaacaggg acaggggttg gcccccaggg   1080

tgctggagca gccggagtcc tccctggtgt tggaggggct ggtgttcctg gcgtgcctgg   1140

ggcaattcct ggaattggag gcatcgcagg cgttgggact ccagctgcag ctgcagctgc   1200

agcagcagcc gctaaggcag ccaagtatgg agctgctgca ggcttagtgc ctggtgggcc   1260

aggctttggc ccgggagtag ttggtgtccc aggagctggc gttccaggtg ttggtgtccc   1320

aggagctggg attccagttg tcccaggtgc tgggatccca ggtgctgcgg ttccaggggt   1380

tgtgtcacca gaagcagctg ctaaggcagc tgcaaaggca gccaaatacg gggccaggcc   1440

cggagtcgga gttggaggca ttcctactta cggggttgga gctgggggct ttcccggctt   1500

tggtgtcgga gtcggaggta tccctggagt cgcaggtgtc cctggtgtcg gaggtgttcc   1560

cggagtcgga ggtgtcccgg gagttggcat ttcccccgaa gctcaggcag cagctgccgc   1620

caaggctgcc aagtacggag tggggacccc agcagctgca gctgctaaag cagccgccaa   1680

agccgcccag tttgggttag ttcctggtgt cggcgtggct cctggagttg gcgtggctcc   1740

tggtgtcggt gtggctcctg gagttggctt ggctcctgga gttggcgtgg ctcctggagt   1800

tggtgtggct cctggcgttg gcgtggctcc cggcattggc cctggtggag ttgcagctgc   1860

agcaaaatcc gctgccaagg tggctgccaa agcccagctc cgagctgcag ctgggcttgg   1920

tgctggcatc cctggacttg gagttggtgt cggcgtccct ggacttggag ttggtgctgg   1980

tgttcctgga cttggagttg gtgctggtgt tcctggcttc ggggcagtac ctggagccct   2040

ggctgccgct aaagcagcca aatatggagc agcagtgcct ggggtccttg gagggctcgg   2100

ggctctcggt ggagtaggca tcccaggcgg tgtggtgggg gcctagtggg agccgctggg   2160

ctcggaggac tcggagtcgg agggcttgga gttccaggtg ttgggggcct tggaggtata   2220

cctccagctg cagccgctaa agcagctaaa tacggagtgg cagcaagacc tggcttcgga   2280

ttgtctccca ttttcccagg tggggcctgc ctggggaaag cttgtggccg gaagagaaaa   2340

tgagcttcct aggacccctg actcacgacc tcatcaacgt tggtgctact gcttggtgga   2400

gaatgtaaac cctttgtaac cccatcccat gcccctccga ctccccaccc caggagggaa   2460

cgggcaggcc gggcggcctt gcagatccac agggcaagga aacaagaggg gagcggccaa   2520

gtgccccgac caggaggccc cctacttcag aggcaagggc catgtggtcc tggcccccca   2580

ccccatccct tcccacctag gagctccccc tccacacagc ctccatctcc aggggaactt   2640

ggtgctacac gctggtgctc ttatcttcct ggggggaggg aggagggaag ggtggcccct   2700

cggggaaccc cctacctggg gctcctctaa agatggtgca gacacttcct gggcagtccc   2760

agctccccct gcccaccagg acccaccgtt ggctgccatc cagttggtac ccaagcacct   2820

gaagcctcaa agctggattc gctctagcat ccctcctctc ctgggtccac ttggccgtct   2880

cctccccacc gatcgctgtt ccccacatct ggggcgcttt tgggttggaa aaccacccca   2940

cactgggaat agccaccttg cccttgtaga atccatccgc ccatccgtcc attcatccat   3000

cggtccgtcc atccatgtcc ccagttgacc gcccggcacc actagctggc tgggtgcacc   3060

caccatcaac ctggttgacc tgtcatggcc gcctgtgccc tgcctccacc cccatcctac   3120

actcccccag ggcgtgcggg gctgtgcaga ctggggtgcc aggcatctcc tccccacccg   3180

gggtgtcccc acatgcagta ctgtataccc cccatccctc cctcggtcca ctgaacttca   3240

gagcagttcc cattcctgcc ccgcccatct ttttgtgtct cgctgtgata gatcaataaa   3300

tattttattt tttgtcctgg atatttgggg attatttttg attgttgata ttctcttttg   3360

gttttattgt tgtggttcat tgaaaaaaaa agataatttt tttttctgat ccggggagct   3420

gtatccccag tagaaaaaac attttaatca ctctaatata actctggatg aaacacacct   3480

ttttttttaa taagaaaaga gaattaactg cttcagaaat gactaataaa tgaaaaacct   3540

ttaaaggaaa                                                          3550


<210>  3835
<211>  608
<212>  PRT
<213>  Homo sapiens

<400>  3835

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val 
        115                 120                 125


Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly Val 
    130                 135                 140


Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro Gly Ala Arg Phe 
145                 150                 155                 160


Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly Ala Gly Val Lys 
                165                 170                 175


Pro Lys Ala Pro Gly Val Gly Gly Ala Phe Ala Gly Ile Pro Gly Val 
            180                 185                 190


Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile 
        195                 200                 205


Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu Pro Tyr Thr Thr Gly 
    210                 215                 220


Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala Gly 
225                 230                 235                 240


Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly Pro Gln Gly Ala Gly 
                245                 250                 255


Ala Ala Gly Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro Gly Val 
            260                 265                 270


Pro Gly Ala Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly Thr Pro 
        275                 280                 285


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly 
    290                 295                 300


Ala Ala Ala Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro Gly Val 
305                 310                 315                 320


Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala 
                325                 330                 335


Gly Ile Pro Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala Val Pro 
            340                 345                 350


Gly Val Val Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala 
        355                 360                 365


Lys Tyr Gly Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro Thr Tyr 
    370                 375                 380


Gly Val Gly Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val Gly Gly 
385                 390                 395                 400


Ile Pro Gly Val Ala Gly Val Pro Gly Val Gly Gly Val Pro Gly Val 
                405                 410                 415


Gly Gly Val Pro Gly Val Gly Ile Ser Pro Glu Ala Gln Ala Ala Ala 
            420                 425                 430


Ala Ala Lys Ala Ala Lys Tyr Gly Val Gly Thr Pro Ala Ala Ala Ala 
        435                 440                 445


Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe Gly Leu Val Pro Gly Val 
    450                 455                 460


Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro 
465                 470                 475                 480


Gly Val Gly Leu Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val 
                485                 490                 495


Ala Pro Gly Val Gly Val Ala Pro Gly Ile Gly Pro Gly Gly Val Ala 
            500                 505                 510


Ala Ala Ala Lys Ser Ala Ala Lys Val Ala Ala Lys Ala Gln Leu Arg 
        515                 520                 525


Ala Ala Ala Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly Val Gly Val 
    530                 535                 540


Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val Pro Gly Leu Gly Val 
545                 550                 555                 560


Gly Ala Gly Val Pro Gly Phe Gly Ala Val Pro Gly Ala Leu Ala Ala 
                565                 570                 575


Ala Lys Ala Ala Lys Tyr Gly Ala Ala Val Pro Gly Val Leu Gly Gly 
            580                 585                 590


Leu Gly Ala Leu Gly Gly Val Gly Ile Pro Gly Gly Val Val Gly Ala 
        595                 600                 605


<210>  3836
<211>  3590
<212>  DNA
<213>  Homo sapiens

<400>  3836
gaaagaacag tcgcagaggg aaagcgggaa agagatgggg gaaagtgtgt gtgtgtgagt     60

gtgtgcttgt gtgcatgtgt gtgcgtgtgt gtgtcaagga aaaaagctcg cagtccagca    120

gcccgggcct gggaggcttg tgagccgggc ctttcgtaat tgtcccctcc ccgcggcccc    180

ctcccccagg cctcccccct ctcccgccct cccgcccgcc ctctctccct ccctctttcc    240

ctcacagccg acgaggcaac aattaggctt tggggataaa acgaggtgcg gagagcgggc    300

tggggcattt ctccccgaga tggcgggtct gacggcggcg gccccgcggc ccggagtcct    360

cctgctcctg ctgtccatcc tccacccctc tcggcctgga ggggtccctg gggccattcc    420

tggtggagtt cctggaggag tcttttatcc aggggctggt ctcggagccc ttggaggagg    480

agcgctgggg cctggaggca aacctcttaa gccagttccc ggagggcttg cgggtgctgg    540

ccttggggca gggctcggcg ccttccccgc agttaccttt ccgggggctc tggtgcctgg    600

tggagtggct gacgctgctg cagcctataa agctgctaag gctggcgctg ggcttggtgg    660

tgtcccagga gttggtggct taggagtgtc tgcaggtgcg gtggttcctc agcctggagc    720

cggagtgaag cctgggaaag tgccgggtgt ggggctgcca ggtgtatacc caggtggcgt    780

gctcccagga gctcggttcc ccggtgtggg ggtgctccct ggagttccca ctggagcagg    840

agttaagccc aaggctccag gtgtaggtgg agcttttgct ggaatcccag gagttggacc    900

ctttggggga ccgcaacctg gagtcccact ggggtatccc atcaaggccc ccaagctgcc    960

tggtggctat ggactgccct acaccacagg gaaactgccc tatggctatg ggcccggagg   1020

agtggctggt gcagcgggca aggctggtta cccaacaggg acaggggttg gcccccaggc   1080

agcagcagca gcggcagcta aagcagcagc aaagttcggt gctggagcag ccggagtcct   1140

ccctggtgtt ggaggggctg gtgttcctgg cgtgcctggg gcaattcctg gaattggagg   1200

catcgcaggc gttgggactc cagctgcagc tgcagctgca gcagcagccg ctaaggcagc   1260

caagtatgga gctgctgcag gcttagtgcc tggtgggcca ggctttggcc cgggagtagt   1320

tggtgtccca ggagctggcg ttccaggtgt tggtgtccca ggagctggga ttccagttgt   1380

cccaggtgct gggatcccag gtgctgcggt tccaggggtt gtgtcaccag aagcagctgc   1440

taaggcagct gcaaaggcag ccaaatacgg ggccaggccc ggagtcggag ttggaggcat   1500

tcctacttac ggggttggag ctgggggctt tcccggcttt ggtgtcggag tcggaggtat   1560

ccctggagtc gcaggtgtcc ctggtgtcgg aggtgttccc ggagtcggag gtgtcccggg   1620

agttggcatt tcccccgaag ctcaggcagc agctgccgcc aaggctgcca agtacgggtt   1680

agttcctggt gtcggcgtgg ctcctggagt tggcgtggct cctggtgtcg gtgtggctcc   1740

tggagttggc ttggctcctg gagttggcgt ggctcctgga gttggtgtgg ctcctggcgt   1800

tggcgtggct cccggcattg gccctggtgg agttgcagct gcagcaaaat ccgctgccaa   1860

ggtggctgcc aaagcccagc tccgagctgc agctgggctt ggtgctggca tccctggact   1920

tggagttggt gtcggcgtcc ctggacttgg agttggtgct ggtgttcctg gacttggagt   1980

tggtgctggt gttcctggct tcggggcagt acctggagcc ctggctgccg ctaaagcagc   2040

caaatatgga gcagcagtgc ctggggtcct tggagggctc ggggctctcg gtggagtagg   2100

catcccaggc ggtgtggtgg gagccggacc cgccgccgcc gctgccgcag ccaaagctgc   2160

tgccaaagcc gcccagtttg gcctagtggg agccgctggg ctcggaggac tcggagtcgg   2220

agggcttgga gttccaggtg ttgggggcct tggaggtata cctccagctg cagccgctaa   2280

agcagctaaa tacggagtgg cagcaagacc tggcttcgga ttgtctccca ttttcccagg   2340

tggggcctgc ctggggaaag cttgtggccg gaagagaaaa tgagcttcct aggacccctg   2400

actcacgacc tcatcaacgt tggtgctact gcttggtgga gaatgtaaac cctttgtaac   2460

cccatcccat gcccctccga ctccccaccc caggagggaa cgggcaggcc gggcggcctt   2520

gcagatccac agggcaagga aacaagaggg gagcggccaa gtgccccgac caggaggccc   2580

cctacttcag aggcaagggc catgtggtcc tggcccccca ccccatccct tcccacctag   2640

gagctccccc tccacacagc ctccatctcc aggggaactt ggtgctacac gctggtgctc   2700

ttatcttcct ggggggaggg aggagggaag ggtggcccct cggggaaccc cctacctggg   2760

gctcctctaa agatggtgca gacacttcct gggcagtccc agctccccct gcccaccagg   2820

acccaccgtt ggctgccatc cagttggtac ccaagcacct gaagcctcaa agctggattc   2880

gctctagcat ccctcctctc ctgggtccac ttggccgtct cctccccacc gatcgctgtt   2940

ccccacatct ggggcgcttt tgggttggaa aaccacccca cactgggaat agccaccttg   3000

cccttgtaga atccatccgc ccatccgtcc attcatccat cggtccgtcc atccatgtcc   3060

ccagttgacc gcccggcacc actagctggc tgggtgcacc caccatcaac ctggttgacc   3120

tgtcatggcc gcctgtgccc tgcctccacc cccatcctac actcccccag ggcgtgcggg   3180

gctgtgcaga ctggggtgcc aggcatctcc tccccacccg gggtgtcccc acatgcagta   3240

ctgtataccc cccatccctc cctcggtcca ctgaacttca gagcagttcc cattcctgcc   3300

ccgcccatct ttttgtgtct cgctgtgata gatcaataaa tattttattt tttgtcctgg   3360

atatttgggg attatttttg attgttgata ttctcttttg gttttattgt tgtggttcat   3420

tgaaaaaaaa agataatttt tttttctgat ccggggagct gtatccccag tagaaaaaac   3480

attttaatca ctctaatata actctggatg aaacacacct ttttttttaa taagaaaaga   3540

gaattaactg cttcagaaat gactaataaa tgaaaaacct ttaaaggaaa              3590


<210>  3837
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  3837

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val 
        115                 120                 125


Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly Val 
    130                 135                 140


Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro Gly Ala Arg Phe 
145                 150                 155                 160


Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly Ala Gly Val Lys 
                165                 170                 175


Pro Lys Ala Pro Gly Val Gly Gly Ala Phe Ala Gly Ile Pro Gly Val 
            180                 185                 190


Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile 
        195                 200                 205


Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu Pro Tyr Thr Thr Gly 
    210                 215                 220


Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala Gly 
225                 230                 235                 240


Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly Pro Gln Ala Ala Ala 
                245                 250                 255


Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe Gly Ala Gly Ala Ala Gly 
            260                 265                 270


Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro Gly Val Pro Gly Ala 
        275                 280                 285


Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly Thr Pro Ala Ala Ala 
    290                 295                 300


Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Ala 
305                 310                 315                 320


Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro Gly Val Val Gly Val 
                325                 330                 335


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Ile Pro 
            340                 345                 350


Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala Val Pro Gly Val Val 
        355                 360                 365


Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Lys Tyr Gly 
    370                 375                 380


Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro Thr Tyr Gly Val Gly 
385                 390                 395                 400


Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val Gly Gly Ile Pro Gly 
                405                 410                 415


Val Ala Gly Val Pro Gly Val Gly Gly Val Pro Gly Val Gly Gly Val 
            420                 425                 430


Pro Gly Val Gly Ile Ser Pro Glu Ala Gln Ala Ala Ala Ala Ala Lys 
        435                 440                 445


Ala Ala Lys Tyr Gly Leu Val Pro Gly Val Gly Val Ala Pro Gly Val 
    450                 455                 460


Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Leu Ala Pro 
465                 470                 475                 480


Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val 
                485                 490                 495


Ala Pro Gly Ile Gly Pro Gly Gly Val Ala Ala Ala Ala Lys Ser Ala 
            500                 505                 510


Ala Lys Val Ala Ala Lys Ala Gln Leu Arg Ala Ala Ala Gly Leu Gly 
        515                 520                 525


Ala Gly Ile Pro Gly Leu Gly Val Gly Val Gly Val Pro Gly Leu Gly 
    530                 535                 540


Val Gly Ala Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val Pro Gly 
545                 550                 555                 560


Phe Gly Ala Val Pro Gly Ala Leu Ala Ala Ala Lys Ala Ala Lys Tyr 
                565                 570                 575


Gly Ala Ala Val Pro Gly Val Leu Gly Gly Leu Gly Ala Leu Gly Gly 
            580                 585                 590


Val Gly Ile Pro Gly Gly Val Val Gly Ala Gly Pro Ala Ala Ala Ala 
        595                 600                 605


Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe Gly Leu Val Gly 
    610                 615                 620


Ala Ala Gly Leu Gly Gly Leu Gly Val Gly Gly Leu Gly Val Pro Gly 
625                 630                 635                 640


Val Gly Gly Leu Gly Gly Ile Pro Pro Ala Ala Ala Ala Lys Ala Ala 
                645                 650                 655


Lys Tyr Gly Val Ala Ala Arg Pro Gly Phe Gly Leu Ser Pro Ile Phe 
            660                 665                 670


Pro Gly Gly Ala Cys Leu Gly Lys Ala Cys Gly Arg Lys Arg Lys 
        675                 680                 685


<210>  3838
<211>  3012
<212>  DNA
<213>  Homo sapiens

<400>  3838
gaaagaacag tcgcagaggg aaagcgggaa agagatgggg gaaagtgtgt gtgtgtgagt     60

gtgtgcttgt gtgcatgtgt gtgcgtgtgt gtgtcaagga aaaaagctcg cagtccagca    120

gcccgggcct gggaggcttg tgagccgggc ctttcgtaat tgtcccctcc ccgcggcccc    180

ctcccccagg cctcccccct ctcccgccct cccgcccgcc ctctctccct ccctctttcc    240

ctcacagccg acgaggcaac aattaggctt tggggataaa acgaggtgcg gagagcgggc    300

tggggcattt ctccccgaga tggcgggtct gacggcggcg gccccgcggc ccggagtcct    360

cctgctcctg ctgtccatcc tccacccctc tcggcctgga ggggtccctg gggccattcc    420

tggtggagtt cctggaggag tcttttatcc aggggctggt ctcggagccc ttggaggagg    480

agcgctgggg cctggaggca aacctcttaa gccagttccc ggagggcttg cgggtgctgg    540

ccttggggca gggctcggcg ccttccccgc agttaccttt ccgggggctc tggtgcctgg    600

tggagtggct gacgctgctg cagcctataa agctgctaag gctggcgctg ggcttggtgg    660

tgtcccagga gttggtggct taggagtgtc tgcaggtgcg gtggttcctc agcctggagc    720

cggagtgaag cctgggaaag tgccgggtgt ggggctgcca ggtgtatacc caggtggcgt    780

gctcccagga gctcggttcc ccggtgtggg ggtgctccct ggagttccca ctggagcagg    840

agttaagccc aaggctccag gtgtaggtgg agcttttgct ggaatcccag gagttggacc    900

ctttggggga ccgcaacctg gagtcccact ggggtatccc atcaaggccc ccaagctgcc    960

tggtggctat ggactgccct acaccacagg gaaactgccc tatggctatg ggcccggagg   1020

agtggctggt gcagcgggca aggctggtta cccaacaggg acaggggttg gcccccaggc   1080

agcagcagca gcggcagcta aagcagcagc aaagttcggt gctggagcag ccggagtcct   1140

ccctggtgtt ggaggggctg gtgttcctgg cgtgcctggg gcaattcctg gaattggagg   1200

catcgcaggc gttgggactc cagctgcagc tgcagctgca gcagcagccg ctaaggcagc   1260

caagtatgga gctgctgcag gcttagtgcc tggtgggcca ggctttggcc cgggagtagt   1320

tggtgtccca ggagctggcg ttccaggtgt tggtgtccca ggagctggga ttccagttgt   1380

cccaggtgct gggatcccag gtgctgcggt tccaggggtt gtgtcaccag aagcagctgc   1440

taaggcagct gcaaaggcag ccaaatacgg ggccaggccc ggagtcggag ttggaggcat   1500

tcctacttac ggggttggag ctgggggctt tcccggcttt ggtgtcggag tcggaggtat   1560

ccctggagtc gcaggtgtcc ctggtgtcgg aggtgttccc ggagtcggag gtgtcccggg   1620

agttggcatt tcccccgaag ctcaggcagc agctgccgcc aaggctgcca agtacggagt   1680

ggggacccca gcagctgcag ctgctaaagc agccgccaaa gccgcccagt ttgggttagt   1740

tcctggtgtc ggcgtggctc ctggagttgg cgtggctcct ggtgtcggtg tggctcctgg   1800

agttggcttg gctcctggag ttggcgtggc tcctggagtt ggtgtggctc ctggcgttgg   1860

cgtggctccc ggcattggcc ctggtggagt tgcagctgca gcaaaatccg ctgccaaggt   1920

ggctgccaaa gcccagctcc gagctgcagc tgggcttggt gctggcatcc ctggacttgg   1980

agttggtgtc ggcgtccctg gacttggagt tggtgctggt gttcctggac ttggagttgg   2040

tgctggtgtt cctggcttcg gggcaggtgc agatgaggga gttaggcgga gcctgtcccc   2100

tgagctcagg gaaggagatc cctcctcctc tcagcacctc cccagcaccc cctcatcacc   2160

cagggtacct ggagccctgg ctgccgctaa agcagccaaa tatggagcag cagtgcctgg   2220

ggtccttgga gggctcgggg ctctcggtgg agtaggcatc ccaggcggtg tggtgggagc   2280

cggacccgcc gccgccgctg ccgcagccaa agctgctgcc aaagccgccc agtttggcct   2340

agtgggagcc gctgggctcg gaggactcgg agtcggaggg cttggagttc caggtgttgg   2400

gggccttgga ggtatacctc cagctgcagc cgctaaagca gctaaatacg gtgctgctgg   2460

ccttggaggt gtcctagggg gtgccgggca gttcccactt ggaggagtgg cagcaagacc   2520

tggcttcgga ttgtctccca ttttcccagg tggggcctgc ctggggaaag cttgtggccg   2580

gaagagaaaa tgagcttcct aggacccctg actcacgacc tcatcaacgt tggtgctact   2640

gcttggtgga gaatgtaaac ccttttatac cccccatccc tccctcggtc cactgaactt   2700

cagagcagtt cccattcctg ccccgcccat ctttttgtgt ctcgctgtga tagatcaata   2760

aatattttat tttttgtcct ggatatttgg ggattatttt tgattgttga tattctcttt   2820

tggttttatt gttgtggttc attgaaaaaa aaagataatt tttttttctg atccggggag   2880

ctgtatcccc agtagaaaaa acattttaat cactctaata taactctgga tgaaacacac   2940

cttttttttt aataagaaaa gagaattaac tgcttcagaa atgactaata aatgaaaaac   3000

ctttaaagga aa                                                       3012


<210>  3839
<211>  757
<212>  PRT
<213>  Homo sapiens

<400>  3839

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val 
        115                 120                 125


Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly Val 
    130                 135                 140


Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro Gly Ala Arg Phe 
145                 150                 155                 160


Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly Ala Gly Val Lys 
                165                 170                 175


Pro Lys Ala Pro Gly Val Gly Gly Ala Phe Ala Gly Ile Pro Gly Val 
            180                 185                 190


Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile 
        195                 200                 205


Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu Pro Tyr Thr Thr Gly 
    210                 215                 220


Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala Gly 
225                 230                 235                 240


Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly Pro Gln Ala Ala Ala 
                245                 250                 255


Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe Gly Ala Gly Ala Ala Gly 
            260                 265                 270


Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro Gly Val Pro Gly Ala 
        275                 280                 285


Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly Thr Pro Ala Ala Ala 
    290                 295                 300


Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Ala 
305                 310                 315                 320


Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro Gly Val Val Gly Val 
                325                 330                 335


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Ile Pro 
            340                 345                 350


Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala Val Pro Gly Val Val 
        355                 360                 365


Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Lys Tyr Gly 
    370                 375                 380


Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro Thr Tyr Gly Val Gly 
385                 390                 395                 400


Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val Gly Gly Ile Pro Gly 
                405                 410                 415


Val Ala Gly Val Pro Gly Val Gly Gly Val Pro Gly Val Gly Gly Val 
            420                 425                 430


Pro Gly Val Gly Ile Ser Pro Glu Ala Gln Ala Ala Ala Ala Ala Lys 
        435                 440                 445


Ala Ala Lys Tyr Gly Val Gly Thr Pro Ala Ala Ala Ala Ala Lys Ala 
    450                 455                 460


Ala Ala Lys Ala Ala Gln Phe Gly Leu Val Pro Gly Val Gly Val Ala 
465                 470                 475                 480


Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly 
                485                 490                 495


Leu Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly 
            500                 505                 510


Val Gly Val Ala Pro Gly Ile Gly Pro Gly Gly Val Ala Ala Ala Ala 
        515                 520                 525


Lys Ser Ala Ala Lys Val Ala Ala Lys Ala Gln Leu Arg Ala Ala Ala 
    530                 535                 540


Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly Val Gly Val Gly Val Pro 
545                 550                 555                 560


Gly Leu Gly Val Gly Ala Gly Val Pro Gly Leu Gly Val Gly Ala Gly 
                565                 570                 575


Val Pro Gly Phe Gly Ala Gly Ala Asp Glu Gly Val Arg Arg Ser Leu 
            580                 585                 590


Ser Pro Glu Leu Arg Glu Gly Asp Pro Ser Ser Ser Gln His Leu Pro 
        595                 600                 605


Ser Thr Pro Ser Ser Pro Arg Val Pro Gly Ala Leu Ala Ala Ala Lys 
    610                 615                 620


Ala Ala Lys Tyr Gly Ala Ala Val Pro Gly Val Leu Gly Gly Leu Gly 
625                 630                 635                 640


Ala Leu Gly Gly Val Gly Ile Pro Gly Gly Val Val Gly Ala Gly Pro 
                645                 650                 655


Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe 
            660                 665                 670


Gly Leu Val Gly Ala Ala Gly Leu Gly Gly Leu Gly Val Gly Gly Leu 
        675                 680                 685


Gly Val Pro Gly Val Gly Gly Leu Gly Gly Ile Pro Pro Ala Ala Ala 
    690                 695                 700


Ala Lys Ala Ala Lys Tyr Gly Ala Ala Gly Leu Gly Gly Val Leu Gly 
705                 710                 715                 720


Gly Ala Gly Gln Phe Pro Leu Gly Gly Val Ala Ala Arg Pro Gly Phe 
                725                 730                 735


Gly Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys Ala Cys 
            740                 745                 750


Gly Arg Lys Arg Lys 
        755


<210>  3840
<211>  3076
<212>  DNA
<213>  Homo sapiens

<400>  3840
ggcaacaatt aggctttggg gataaaacga ggtgcggaga gcgggctggg gcatttctcc     60

ccgagatggc gggtctgacg gcggcggccc cgcggcccgg agtcctcctg ctcctgctgt    120

ccatcctcca cccctctcgg cctggagggg tccctggggc cattcctggt ggagttcctg    180

gaggagtctt ttatccagcg ctggggcctg gaggcaaacc tcttaagcca gttcccggag    240

ggcttgcggg tgctggcctt ggggcagggc tcggcgcctt ccccgcagtt acctttccgg    300

gggctctggt gcctggtgga gtggctgacg ctgctgcagc ctataaagct gctaaggctg    360

gcgctgggct tggtggtgtc ccaggagttg gtggcttagg agtgtctgca ggtgcggtgg    420

ttcctcagcc tggagccgga gtgaagcctg ggaaagtgcc gggtgtgggg ctgccaggtg    480

tatacccagg tggcgtgctc ccaggagctc ggttccccgg tgtgggggtg ctccctggag    540

ttcccactgg agcaggagtt aagcccaagg ctccaggtgt aggtggagct tttgctggaa    600

tcccaggagt tggacccttt gggggaccgc aacctggagt cccactgggg tatcccatca    660

aggcccccaa gctgcctggt ggctatggac tgccctacac cacagggaaa ctgccctatg    720

gctatgggcc cggaggagtg gctggtgcag cgggcaaggc tggttaccca acagggacag    780

gggttggccc ccaggcagca gcagcagcgg cagctaaagc agcagcaaag ttcggtgctg    840

gagcagccgg agtcctccct ggtgttggag gggctggtgt tcctggcgtg cctggggcaa    900

ttcctggaat tggaggcatc gcaggcgttg ggactccagc tgcagctgca gctgcagcag    960

cagccgctaa ggcagccaag tatggagctg ctgcaggctt agtgcctggt gggccaggct   1020

ttggcccggg agtagttggt gtcccaggag ctggcgttcc aggtgttggt gtcccaggag   1080

ctgggattcc agttgtccca ggtgctggga tcccaggtgc tgcggttcca ggggttgtgt   1140

caccagaagc agctgctaag gcagctgcaa aggcagccaa atacggggcc aggcccggag   1200

tcggagttgg aggcattcct acttacgggg ttggagctgg gggctttccc ggctttggtg   1260

tcggagtcgg aggtatccct ggagtcgcag gtgtccctgg tgtcggaggt gttcccggag   1320

tcggaggtgt cccgggagtt ggcatttccc ccgaagctca ggcagcagct gccgccaagg   1380

ctgccaagta cgggttagtt cctggtgtcg gcgtggctcc tggagttggc gtggctcctg   1440

gtgtcggtgt ggctcctgga gttggcttgg ctcctggagt tggcgtggct cctggagttg   1500

gtgtggctcc tggcgttggc gtggctcccg gcattggccc tggtggagtt gcagctgcag   1560

caaaatccgc tgccaaggtg gctgccaaag cccagctccg agctgcagct gggcttggtg   1620

ctggcatccc tggacttgga gttggtgtcg gcgtccctgg acttggagtt ggtgctggtg   1680

ttcctggact tggagttggt gctggtgttc ctggcttcgg ggcagtacct ggagccctgg   1740

ctgccgctaa agcagccaaa tatggagcag cagtgcctgg ggtccttgga gggctcgggg   1800

ctctcggtgg agtaggcatc ccaggcggtg tggtgggagc cggacccgcc gccgccgctg   1860

ccgcagccaa agctgctgcc aaagccgccc agtttggcct agtgggagcc gctgggctcg   1920

gaggactcgg agtcggaggg cttggagttc caggtgttgg gggccttgga ggtatacctc   1980

cagctgcagc cgctaaagca gctaaatacg gagtggcagc aagacctggc ttcggattgt   2040

ctcccatttt cccaggtggg gcctgcctgg ggaaagcttg tggccggaag agaaaatgag   2100

cttcctagga cccctgactc acgacctcat caacgttggt gctactgctt ggtggagaat   2160

gtaaaccctt tgtaacccca tcccatgccc ctccgactcc ccaccccagg agggaacggg   2220

caggccgggc ggccttgcag atccacaggg caaggaaaca agaggggagc ggccaagtgc   2280

cccgaccagg aggcccccta cttcagaggc aagggccatg tggtcctggc cccccacccc   2340

atcccttccc acctaggagc tccccctcca cacagcctcc atctccaggg gaacttggtg   2400

ctacacgctg gtgctcttat cttcctgggg ggagggagga gggaagggtg gcccctcggg   2460

gaacccccta cctggggctc ctctaaagat ggtgcagaca cttcctgggc agtcccagct   2520

ccccctgccc accaggaccc accgttggct gccatccagt tggtacccaa gcacctgaag   2580

cctcaaagct ggattcgctc tagcatccct cctctcctgg gtccacttgg ccgtctcctc   2640

cccaccgatc gctgttcccc acatctgggg cgcttttggg ttggaaaacc accccacact   2700

gggaatagcc accttgccct tgtagaatcc atccgcccat ccgtccattc atccatcggt   2760

ccgtccatcc atgtccccag ttgaccgccc ggcaccacta gctggctggg tgcacccacc   2820

atcaacctgg ttgacctgtc atggccgcct gtgccctgcc tccaccccca tcctacactc   2880

ccccagggcg tgcggggctg tgcagactgg ggtgccaggc atctcctccc cacccggggt   2940

gtccccacat gcagtactgt atacccccca tccctccctc ggtccactga acttcagagc   3000

agttcccatt cctgccccgc ccatcttttt gtgtctcgct gtgatagatc aataaatatt   3060

ttattttttg tcctgg                                                   3076


<210>  3841
<211>  677
<212>  PRT
<213>  Homo sapiens

<400>  3841

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Ala Leu Gly Pro 
        35                  40                  45


Gly Gly Lys Pro Leu Lys Pro Val Pro Gly Gly Leu Ala Gly Ala Gly 
    50                  55                  60


Leu Gly Ala Gly Leu Gly Ala Phe Pro Ala Val Thr Phe Pro Gly Ala 
65                  70                  75                  80


Leu Val Pro Gly Gly Val Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala 
                85                  90                  95


Lys Ala Gly Ala Gly Leu Gly Gly Val Pro Gly Val Gly Gly Leu Gly 
            100                 105                 110


Val Ser Ala Gly Ala Val Val Pro Gln Pro Gly Ala Gly Val Lys Pro 
        115                 120                 125


Gly Lys Val Pro Gly Val Gly Leu Pro Gly Val Tyr Pro Gly Gly Val 
    130                 135                 140


Leu Pro Gly Ala Arg Phe Pro Gly Val Gly Val Leu Pro Gly Val Pro 
145                 150                 155                 160


Thr Gly Ala Gly Val Lys Pro Lys Ala Pro Gly Val Gly Gly Ala Phe 
                165                 170                 175


Ala Gly Ile Pro Gly Val Gly Pro Phe Gly Gly Pro Gln Pro Gly Val 
            180                 185                 190


Pro Leu Gly Tyr Pro Ile Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly 
        195                 200                 205


Leu Pro Tyr Thr Thr Gly Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly 
    210                 215                 220


Val Ala Gly Ala Ala Gly Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val 
225                 230                 235                 240


Gly Pro Gln Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe 
                245                 250                 255


Gly Ala Gly Ala Ala Gly Val Leu Pro Gly Val Gly Gly Ala Gly Val 
            260                 265                 270


Pro Gly Val Pro Gly Ala Ile Pro Gly Ile Gly Gly Ile Ala Gly Val 
        275                 280                 285


Gly Thr Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala 
    290                 295                 300


Lys Tyr Gly Ala Ala Ala Gly Leu Val Pro Gly Gly Pro Gly Phe Gly 
305                 310                 315                 320


Pro Gly Val Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
                325                 330                 335


Pro Gly Ala Gly Ile Pro Val Val Pro Gly Ala Gly Ile Pro Gly Ala 
            340                 345                 350


Ala Val Pro Gly Val Val Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala 
        355                 360                 365


Lys Ala Ala Lys Tyr Gly Ala Arg Pro Gly Val Gly Val Gly Gly Ile 
    370                 375                 380


Pro Thr Tyr Gly Val Gly Ala Gly Gly Phe Pro Gly Phe Gly Val Gly 
385                 390                 395                 400


Val Gly Gly Ile Pro Gly Val Ala Gly Val Pro Gly Val Gly Gly Val 
                405                 410                 415


Pro Gly Val Gly Gly Val Pro Gly Val Gly Ile Ser Pro Glu Ala Gln 
            420                 425                 430


Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Leu Val Pro Gly Val 
        435                 440                 445


Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro 
    450                 455                 460


Gly Val Gly Leu Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val 
465                 470                 475                 480


Ala Pro Gly Val Gly Val Ala Pro Gly Ile Gly Pro Gly Gly Val Ala 
                485                 490                 495


Ala Ala Ala Lys Ser Ala Ala Lys Val Ala Ala Lys Ala Gln Leu Arg 
            500                 505                 510


Ala Ala Ala Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly Val Gly Val 
        515                 520                 525


Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val Pro Gly Leu Gly Val 
    530                 535                 540


Gly Ala Gly Val Pro Gly Phe Gly Ala Val Pro Gly Ala Leu Ala Ala 
545                 550                 555                 560


Ala Lys Ala Ala Lys Tyr Gly Ala Ala Val Pro Gly Val Leu Gly Gly 
                565                 570                 575


Leu Gly Ala Leu Gly Gly Val Gly Ile Pro Gly Gly Val Val Gly Ala 
            580                 585                 590


Gly Pro Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala 
        595                 600                 605


Gln Phe Gly Leu Val Gly Ala Ala Gly Leu Gly Gly Leu Gly Val Gly 
    610                 615                 620


Gly Leu Gly Val Pro Gly Val Gly Gly Leu Gly Gly Ile Pro Pro Ala 
625                 630                 635                 640


Ala Ala Ala Lys Ala Ala Lys Tyr Gly Val Ala Ala Arg Pro Gly Phe 
                645                 650                 655


Gly Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys Ala Cys 
            660                 665                 670


Gly Arg Lys Arg Lys 
        675


<210>  3842
<211>  3130
<212>  DNA
<213>  Homo sapiens

<400>  3842
ggcaacaatt aggctttggg gataaaacga ggtgcggaga gcgggctggg gcatttctcc     60

ccgagatggc gggtctgacg gcggcggccc cgcggcccgg agtcctcctg ctcctgctgt    120

ccatcctcca cccctctcgg cctggagggg tccctggggc cattcctggt ggagttcctg    180

gaggagtctt ttatccagcg ctggggcctg gaggcaaacc tcttaagcca gttcccggag    240

ggcttgcggg tgctggcctt ggggcagggc tcggcgcctt ccccgcagtt acctttccgg    300

gggctctggt gcctggtgga gtggctgacg ctgctgcagc ctataaagct gctaaggctg    360

gcgctgggct tggtggtgtc ccaggagttg gtggcttagg agtgtctgca ggtgcggtgg    420

ttcctcagcc tggagccgga gtgaagcctg ggaaagtgcc gggtgtgggg ctgccaggtg    480

tatacccagg tggcgtgctc ccaggagctc ggttccccgg tgtgggggtg ctccctggag    540

ttcccactgg agcaggagtt aagcccaagg ctccaggtgt aggtggagct tttgctggaa    600

tcccaggagt tggacccttt gggggaccgc aacctggagt cccactgggg tatcccatca    660

aggcccccaa gctgcctggt ggctatggac tgccctacac cacagggaaa ctgccctatg    720

gctatgggcc cggaggagtg gctggtgcag cgggcaaggc tggttaccca acagggacag    780

gggttggccc ccaggcagca gcagcagcgg cagctaaagc agcagcaaag ttcggtgctg    840

gagcagccgg agtcctccct ggtgttggag gggctggtgt tcctggcgtg cctggggcaa    900

ttcctggaat tggaggcatc gcaggcgttg ggactccagc tgcagctgca gctgcagcag    960

cagccgctaa ggcagccaag tatggagctg ctgcaggctt agtgcctggt gggccaggct   1020

ttggcccggg agtagttggt gtcccaggag ctggcgttcc aggtgttggt gtcccaggag   1080

ctgggattcc agttgtccca ggtgctggga tcccaggtgc tgcggttcca ggggttgtgt   1140

caccagaagc agctgctaag gcagctgcaa aggcagccaa atacggggcc aggcccggag   1200

tcggagttgg aggcattcct acttacgggg ttggagctgg gggctttccc ggctttggtg   1260

tcggagtcgg aggtatccct ggagtcgcag gtgtccctgg tgtcggaggt gttcccggag   1320

tcggaggtgt cccgggagtt ggcatttccc ccgaagctca ggcagcagct gccgccaagg   1380

ctgccaagta cgggttagtt cctggtgtcg gcgtggctcc tggagttggc gtggctcctg   1440

gtgtcggtgt ggctcctgga gttggcttgg ctcctggagt tggcgtggct cctggagttg   1500

gtgtggctcc tggcgttggc gtggctcccg gcattggccc tggtggagtt gcagctgcag   1560

caaaatccgc tgccaaggtg gctgccaaag cccagctccg agctgcagct gggcttggtg   1620

ctggcatccc tggacttgga gttggtgtcg gcgtccctgg acttggagtt ggtgctggtg   1680

ttcctggact tggagttggt gctggtgttc ctggcttcgg ggcagtacct ggagccctgg   1740

ctgccgctaa agcagccaaa tatggagcag cagtgcctgg ggtccttgga gggctcgggg   1800

ctctcggtgg agtaggcatc ccaggcggtg tggtgggagc cggacccgcc gccgccgctg   1860

ccgcagccaa agctgctgcc aaagccgccc agtttggcct agtgggagcc gctgggctcg   1920

gaggactcgg agtcggaggg cttggagttc caggtgttgg gggccttgga ggtatacctc   1980

cagctgcagc cgctaaagca gctaaatacg gtgctgctgg ccttggaggt gtcctagggg   2040

gtgccgggca gttcccactt ggaggagtgg cagcaagacc tggcttcgga ttgtctccca   2100

ttttcccagg tggggcctgc ctggggaaag cttgtggccg gaagagaaaa tgagcttcct   2160

aggacccctg actcacgacc tcatcaacgt tggtgctact gcttggtgga gaatgtaaac   2220

cctttgtaac cccatcccat gcccctccga ctccccaccc caggagggaa cgggcaggcc   2280

gggcggcctt gcagatccac agggcaagga aacaagaggg gagcggccaa gtgccccgac   2340

caggaggccc cctacttcag aggcaagggc catgtggtcc tggcccccca ccccatccct   2400

tcccacctag gagctccccc tccacacagc ctccatctcc aggggaactt ggtgctacac   2460

gctggtgctc ttatcttcct ggggggaggg aggagggaag ggtggcccct cggggaaccc   2520

cctacctggg gctcctctaa agatggtgca gacacttcct gggcagtccc agctccccct   2580

gcccaccagg acccaccgtt ggctgccatc cagttggtac ccaagcacct gaagcctcaa   2640

agctggattc gctctagcat ccctcctctc ctgggtccac ttggccgtct cctccccacc   2700

gatcgctgtt ccccacatct ggggcgcttt tgggttggaa aaccacccca cactgggaat   2760

agccaccttg cccttgtaga atccatccgc ccatccgtcc attcatccat cggtccgtcc   2820

atccatgtcc ccagttgacc gcccggcacc actagctggc tgggtgcacc caccatcaac   2880

ctggttgacc tgtcatggcc gcctgtgccc tgcctccacc cccatcctac actcccccag   2940

ggcgtgcggg gctgtgcaga ctggggtgcc aggcatctcc tccccacccg gggtgtcccc   3000

acatgcagta ctgtataccc cccatccctc cctcggtcca ctgaacttca gagcagttcc   3060

cattcctgcc ccgcccatct ttttgtgtct cgctgtgata gatcaataaa tattttattt   3120

tttgtcctgg                                                          3130


<210>  3843
<211>  695
<212>  PRT
<213>  Homo sapiens

<400>  3843

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Ala Leu Gly Pro 
        35                  40                  45


Gly Gly Lys Pro Leu Lys Pro Val Pro Gly Gly Leu Ala Gly Ala Gly 
    50                  55                  60


Leu Gly Ala Gly Leu Gly Ala Phe Pro Ala Val Thr Phe Pro Gly Ala 
65                  70                  75                  80


Leu Val Pro Gly Gly Val Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala 
                85                  90                  95


Lys Ala Gly Ala Gly Leu Gly Gly Val Pro Gly Val Gly Gly Leu Gly 
            100                 105                 110


Val Ser Ala Gly Ala Val Val Pro Gln Pro Gly Ala Gly Val Lys Pro 
        115                 120                 125


Gly Lys Val Pro Gly Val Gly Leu Pro Gly Val Tyr Pro Gly Gly Val 
    130                 135                 140


Leu Pro Gly Ala Arg Phe Pro Gly Val Gly Val Leu Pro Gly Val Pro 
145                 150                 155                 160


Thr Gly Ala Gly Val Lys Pro Lys Ala Pro Gly Val Gly Gly Ala Phe 
                165                 170                 175


Ala Gly Ile Pro Gly Val Gly Pro Phe Gly Gly Pro Gln Pro Gly Val 
            180                 185                 190


Pro Leu Gly Tyr Pro Ile Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly 
        195                 200                 205


Leu Pro Tyr Thr Thr Gly Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly 
    210                 215                 220


Val Ala Gly Ala Ala Gly Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val 
225                 230                 235                 240


Gly Pro Gln Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe 
                245                 250                 255


Gly Ala Gly Ala Ala Gly Val Leu Pro Gly Val Gly Gly Ala Gly Val 
            260                 265                 270


Pro Gly Val Pro Gly Ala Ile Pro Gly Ile Gly Gly Ile Ala Gly Val 
        275                 280                 285


Gly Thr Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala 
    290                 295                 300


Lys Tyr Gly Ala Ala Ala Gly Leu Val Pro Gly Gly Pro Gly Phe Gly 
305                 310                 315                 320


Pro Gly Val Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
                325                 330                 335


Pro Gly Ala Gly Ile Pro Val Val Pro Gly Ala Gly Ile Pro Gly Ala 
            340                 345                 350


Ala Val Pro Gly Val Val Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala 
        355                 360                 365


Lys Ala Ala Lys Tyr Gly Ala Arg Pro Gly Val Gly Val Gly Gly Ile 
    370                 375                 380


Pro Thr Tyr Gly Val Gly Ala Gly Gly Phe Pro Gly Phe Gly Val Gly 
385                 390                 395                 400


Val Gly Gly Ile Pro Gly Val Ala Gly Val Pro Gly Val Gly Gly Val 
                405                 410                 415


Pro Gly Val Gly Gly Val Pro Gly Val Gly Ile Ser Pro Glu Ala Gln 
            420                 425                 430


Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Leu Val Pro Gly Val 
        435                 440                 445


Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro 
    450                 455                 460


Gly Val Gly Leu Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val 
465                 470                 475                 480


Ala Pro Gly Val Gly Val Ala Pro Gly Ile Gly Pro Gly Gly Val Ala 
                485                 490                 495


Ala Ala Ala Lys Ser Ala Ala Lys Val Ala Ala Lys Ala Gln Leu Arg 
            500                 505                 510


Ala Ala Ala Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly Val Gly Val 
        515                 520                 525


Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val Pro Gly Leu Gly Val 
    530                 535                 540


Gly Ala Gly Val Pro Gly Phe Gly Ala Val Pro Gly Ala Leu Ala Ala 
545                 550                 555                 560


Ala Lys Ala Ala Lys Tyr Gly Ala Ala Val Pro Gly Val Leu Gly Gly 
                565                 570                 575


Leu Gly Ala Leu Gly Gly Val Gly Ile Pro Gly Gly Val Val Gly Ala 
            580                 585                 590


Gly Pro Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala 
        595                 600                 605


Gln Phe Gly Leu Val Gly Ala Ala Gly Leu Gly Gly Leu Gly Val Gly 
    610                 615                 620


Gly Leu Gly Val Pro Gly Val Gly Gly Leu Gly Gly Ile Pro Pro Ala 
625                 630                 635                 640


Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Gly Leu Gly Gly Val 
                645                 650                 655


Leu Gly Gly Ala Gly Gln Phe Pro Leu Gly Gly Val Ala Ala Arg Pro 
            660                 665                 670


Gly Phe Gly Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys 
        675                 680                 685


Ala Cys Gly Arg Lys Arg Lys 
    690                 695


<210>  3844
<211>  3187
<212>  DNA
<213>  Homo sapiens

<400>  3844
ggcaacaatt aggctttggg gataaaacga ggtgcggaga gcgggctggg gcatttctcc     60

ccgagatggc gggtctgacg gcggcggccc cgcggcccgg agtcctcctg ctcctgctgt    120

ccatcctcca cccctctcgg cctggagggg tccctggggc cattcctggt ggagttcctg    180

gaggagtctt ttatccagcg ctggggcctg gaggcaaacc tcttaagcca gttcccggag    240

ggcttgcggg tgctggcctt ggggcagggc tcggcgcctt ccccgcagtt acctttccgg    300

gggctctggt gcctggtgga gtggctgacg ctgctgcagc ctataaagct gctaaggctg    360

gcgctgggct tggtggtgtc ccaggagttg gtggcttagg agtgtctgca ggtgcggtgg    420

ttcctcagcc tggagccgga gtgaagcctg ggaaagtgcc gggtgtgggg ctgccaggtg    480

tatacccagg tggcgtgctc ccaggagctc ggttccccgg tgtgggggtg ctccctggag    540

ttcccactgg agcaggagtt aagcccaagg ctccaggtgt aggtggagct tttgctggaa    600

tcccaggagt tggacccttt gggggaccgc aacctggagt cccactgggg tatcccatca    660

aggcccccaa gctgcctggt ggctatggac tgccctacac cacagggaaa ctgccctatg    720

gctatgggcc cggaggagtg gctggtgcag cgggcaaggc tggttaccca acagggacag    780

gggttggccc ccaggcagca gcagcagcgg cagctaaagc agcagcaaag ttcggtgctg    840

gagcagccgg agtcctccct ggtgttggag gggctggtgt tcctggcgtg cctggggcaa    900

ttcctggaat tggaggcatc gcaggcgttg ggactccagc tgcagctgca gctgcagcag    960

cagccgctaa ggcagccaag tatggagctg ctgcaggctt agtgcctggt gggccaggct   1020

ttggcccggg agtagttggt gtcccaggag ctggcgttcc aggtgttggt gtcccaggag   1080

ctgggattcc agttgtccca ggtgctggga tcccaggtgc tgcggttcca ggggttgtgt   1140

caccagaagc agctgctaag gcagctgcaa aggcagccaa atacggggcc aggcccggag   1200

tcggagttgg aggcattcct acttacgggg ttggagctgg gggctttccc ggctttggtg   1260

tcggagtcgg aggtatccct ggagtcgcag gtgtccctgg tgtcggaggt gttcccggag   1320

tcggaggtgt cccgggagtt ggcatttccc ccgaagctca ggcagcagct gccgccaagg   1380

ctgccaagta cggagtgggg accccagcag ctgcagctgc taaagcagcc gccaaagccg   1440

cccagtttgg gttagttcct ggtgtcggcg tggctcctgg agttggcgtg gctcctggtg   1500

tcggtgtggc tcctggagtt ggcttggctc ctggagttgg cgtggctcct ggagttggtg   1560

tggctcctgg cgttggcgtg gctcccggca ttggccctgg tggagttgca gctgcagcaa   1620

aatccgctgc caaggtggct gccaaagccc agctccgagc tgcagctggg cttggtgctg   1680

gcatccctgg acttggagtt ggtgtcggcg tccctggact tggagttggt gctggtgttc   1740

ctggacttgg agttggtgct ggtgttcctg gcttcggggc agtacctgga gccctggctg   1800

ccgctaaagc agccaaatat ggagcagcag tgcctggggt ccttggaggg ctcggggctc   1860

tcggtggagt aggcatccca ggcggtgtgg tgggagccgg acccgccgcc gccgctgccg   1920

cagccaaagc tgctgccaaa gccgcccagt ttggcctagt gggagccgct gggctcggag   1980

gactcggagt cggagggctt ggagttccag gtgttggggg ccttggaggt atacctccag   2040

ctgcagccgc taaagcagct aaatacggtg ctgctggcct tggaggtgtc ctagggggtg   2100

ccgggcagtt cccacttgga ggagtggcag caagacctgg cttcggattg tctcccattt   2160

tcccaggtgg ggcctgcctg gggaaagctt gtggccggaa gagaaaatga gcttcctagg   2220

acccctgact cacgacctca tcaacgttgg tgctactgct tggtggagaa tgtaaaccct   2280

ttgtaacccc atcccatgcc cctccgactc cccaccccag gagggaacgg gcaggccggg   2340

cggccttgca gatccacagg gcaaggaaac aagaggggag cggccaagtg ccccgaccag   2400

gaggccccct acttcagagg caagggccat gtggtcctgg ccccccaccc catcccttcc   2460

cacctaggag ctccccctcc acacagcctc catctccagg ggaacttggt gctacacgct   2520

ggtgctctta tcttcctggg gggagggagg agggaagggt ggcccctcgg ggaaccccct   2580

acctggggct cctctaaaga tggtgcagac acttcctggg cagtcccagc tccccctgcc   2640

caccaggacc caccgttggc tgccatccag ttggtaccca agcacctgaa gcctcaaagc   2700

tggattcgct ctagcatccc tcctctcctg ggtccacttg gccgtctcct ccccaccgat   2760

cgctgttccc cacatctggg gcgcttttgg gttggaaaac caccccacac tgggaatagc   2820

caccttgccc ttgtagaatc catccgccca tccgtccatt catccatcgg tccgtccatc   2880

catgtcccca gttgaccgcc cggcaccact agctggctgg gtgcacccac catcaacctg   2940

gttgacctgt catggccgcc tgtgccctgc ctccaccccc atcctacact cccccagggc   3000

gtgcggggct gtgcagactg gggtgccagg catctcctcc ccacccgggg tgtccccaca   3060

tgcagtactg tatacccccc atccctccct cggtccactg aacttcagag cagttcccat   3120

tcctgccccg cccatctttt tgtgtctcgc tgtgatagat caataaatat tttatttttt   3180

gtcctgg                                                             3187


<210>  3845
<211>  714
<212>  PRT
<213>  Homo sapiens

<400>  3845

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Ala Leu Gly Pro 
        35                  40                  45


Gly Gly Lys Pro Leu Lys Pro Val Pro Gly Gly Leu Ala Gly Ala Gly 
    50                  55                  60


Leu Gly Ala Gly Leu Gly Ala Phe Pro Ala Val Thr Phe Pro Gly Ala 
65                  70                  75                  80


Leu Val Pro Gly Gly Val Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala 
                85                  90                  95


Lys Ala Gly Ala Gly Leu Gly Gly Val Pro Gly Val Gly Gly Leu Gly 
            100                 105                 110


Val Ser Ala Gly Ala Val Val Pro Gln Pro Gly Ala Gly Val Lys Pro 
        115                 120                 125


Gly Lys Val Pro Gly Val Gly Leu Pro Gly Val Tyr Pro Gly Gly Val 
    130                 135                 140


Leu Pro Gly Ala Arg Phe Pro Gly Val Gly Val Leu Pro Gly Val Pro 
145                 150                 155                 160


Thr Gly Ala Gly Val Lys Pro Lys Ala Pro Gly Val Gly Gly Ala Phe 
                165                 170                 175


Ala Gly Ile Pro Gly Val Gly Pro Phe Gly Gly Pro Gln Pro Gly Val 
            180                 185                 190


Pro Leu Gly Tyr Pro Ile Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly 
        195                 200                 205


Leu Pro Tyr Thr Thr Gly Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly 
    210                 215                 220


Val Ala Gly Ala Ala Gly Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val 
225                 230                 235                 240


Gly Pro Gln Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe 
                245                 250                 255


Gly Ala Gly Ala Ala Gly Val Leu Pro Gly Val Gly Gly Ala Gly Val 
            260                 265                 270


Pro Gly Val Pro Gly Ala Ile Pro Gly Ile Gly Gly Ile Ala Gly Val 
        275                 280                 285


Gly Thr Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala 
    290                 295                 300


Lys Tyr Gly Ala Ala Ala Gly Leu Val Pro Gly Gly Pro Gly Phe Gly 
305                 310                 315                 320


Pro Gly Val Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
                325                 330                 335


Pro Gly Ala Gly Ile Pro Val Val Pro Gly Ala Gly Ile Pro Gly Ala 
            340                 345                 350


Ala Val Pro Gly Val Val Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala 
        355                 360                 365


Lys Ala Ala Lys Tyr Gly Ala Arg Pro Gly Val Gly Val Gly Gly Ile 
    370                 375                 380


Pro Thr Tyr Gly Val Gly Ala Gly Gly Phe Pro Gly Phe Gly Val Gly 
385                 390                 395                 400


Val Gly Gly Ile Pro Gly Val Ala Gly Val Pro Gly Val Gly Gly Val 
                405                 410                 415


Pro Gly Val Gly Gly Val Pro Gly Val Gly Ile Ser Pro Glu Ala Gln 
            420                 425                 430


Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Val Gly Thr Pro Ala 
        435                 440                 445


Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe Gly Leu Val 
    450                 455                 460


Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly 
465                 470                 475                 480


Val Ala Pro Gly Val Gly Leu Ala Pro Gly Val Gly Val Ala Pro Gly 
                485                 490                 495


Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Ile Gly Pro Gly 
            500                 505                 510


Gly Val Ala Ala Ala Ala Lys Ser Ala Ala Lys Val Ala Ala Lys Ala 
        515                 520                 525


Gln Leu Arg Ala Ala Ala Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly 
    530                 535                 540


Val Gly Val Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val Pro Gly 
545                 550                 555                 560


Leu Gly Val Gly Ala Gly Val Pro Gly Phe Gly Ala Val Pro Gly Ala 
                565                 570                 575


Leu Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Val Pro Gly Val 
            580                 585                 590


Leu Gly Gly Leu Gly Ala Leu Gly Gly Val Gly Ile Pro Gly Gly Val 
        595                 600                 605


Val Gly Ala Gly Pro Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala 
    610                 615                 620


Lys Ala Ala Gln Phe Gly Leu Val Gly Ala Ala Gly Leu Gly Gly Leu 
625                 630                 635                 640


Gly Val Gly Gly Leu Gly Val Pro Gly Val Gly Gly Leu Gly Gly Ile 
                645                 650                 655


Pro Pro Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Gly Leu 
            660                 665                 670


Gly Gly Val Leu Gly Gly Ala Gly Gln Phe Pro Leu Gly Gly Val Ala 
        675                 680                 685


Ala Arg Pro Gly Phe Gly Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys 
    690                 695                 700


Leu Gly Lys Ala Cys Gly Arg Lys Arg Lys 
705                 710


<210>  3846
<211>  3360
<212>  DNA
<213>  Homo sapiens

<400>  3846
ggcaacaatt aggctttggg gataaaacga ggtgcggaga gcgggctggg gcatttctcc     60

ccgagatggc gggtctgacg gcggcggccc cgcggcccgg agtcctcctg ctcctgctgt    120

ccatcctcca cccctctcgg cctggagggg tccctggggc cattcctggt ggagttcctg    180

gaggagtctt ttatccagcg ctggggcctg gaggcaaacc tcttaagcca gttcccggag    240

ggcttgcggg tgctggcctt ggggcagggc tcggcgcctt ccccgcagtt acctttccgg    300

gggctctggt gcctggtgga gtggctgacg ctgctgcagc ctataaagct gctaaggctg    360

gcgctgggct tggtggtgtc ccaggagttg gtggcttagg agtgtctgca ggtgcggtgg    420

ttcctcagcc tggagccgga gtgaagcctg ggaaagtgcc gggtgtgggg ctgccaggtg    480

tatacccagg tggcgtgctc ccaggagctc ggttccccgg tgtgggggtg ctccctggag    540

ttcccactgg agcaggagtt aagcccaagg ctccaggtgt aggtggagct tttgctggaa    600

tcccaggagt tggacccttt gggggaccgc aacctggagt cccactgggg tatcccatca    660

aggcccccaa gctgcctggt ggctatggac tgccctacac cacagggaaa ctgccctatg    720

gctatgggcc cggaggagtg gctggtgcag cgggcaaggc tggttaccca acagggacag    780

gggttggccc ccaggcagca gcagcagcgg cagctaaagc agcagcaaag ttcggtgctg    840

gagcagccgg agtcctccct ggtgttggag gggctggtgt tcctggcgtg cctggggcaa    900

ttcctggaat tggaggcatc gcaggcgttg ggactccagc tgcagctgca gctgcagcag    960

cagccgctaa ggcagccaag tatggagctg ctgcaggctt agtgcctggt gggccaggct   1020

ttggcccggg agtagttggt gtcccaggag ctggcgttcc aggtgttggt gtcccaggag   1080

ctgggattcc agttgtccca ggtgctggga tcccaggtgc tgcggttcca ggggttgtgt   1140

caccagaagc agctgctaag gcagctgcaa aggcagccaa atacggggcc aggcccggag   1200

tcggagttgg aggcattcct acttacgggg ttggagctgg gggctttccc ggctttggtg   1260

tcggagtcgg aggtatccct ggagtcgcag gtgtccctgg tgtcggaggt gttcccggag   1320

tcggaggtgt cccgggagtt ggcatttccc ccgaagctca ggcagcagct gccgccaagg   1380

ctgccaagta cgggttagtt cctggtgtcg gcgtggctcc tggagttggc gtggctcctg   1440

gtgtcggtgt ggctcctgga gttggcttgg ctcctggagt tggcgtggct cctggagttg   1500

gtgtggctcc tggcgttggc gtggctcccg gcattggccc tggtggagtt gcagctgcag   1560

caaaatccgc tgccaaggtg gctgccaaag cccagctccg agctgcagct gggcttggtg   1620

ctggcatccc tggacttgga gttggtgtcg gcgtccctgg acttggagtt ggtgctggtg   1680

ttcctggact tggagttggt gctggtgttc ctggcttcgg ggcagtacct ggagccctgg   1740

ctgccgctaa agcagccaaa tatggagcag cagtgcctgg ggtccttgga gggctcgggg   1800

ctctcggtgg agtaggcatc ccaggcggtg tggtgggagc cggacccgcc gccgccgctg   1860

ccgcagccaa agctgctgcc aaagccgccc agtttggcct agtgggagcc gctgggctcg   1920

gaggactcgg agtcggaggg cttggagttc caggtgttgg gggccttgga ggtatacctc   1980

cagctgcagc cgctaaagca gctaaatacg gtgctgctgg ccttggaggt gtcctagggg   2040

gtgccgggca gttcccactt ggaggagtgg cagcaagacc tggcttcgga ttgtctccca   2100

ttttcccagg tggggcctgc ctggggaaag cttgtggccg gaagagaaaa tgagcttcct   2160

aggacccctg actcacgacc tcatcaacgt tggtgctact gcttggtgga gaatgtaaac   2220

cctttgtaac cccatcccat gcccctccga ctccccaccc caggagggaa cgggcaggcc   2280

gggcggcctt gcagatccac agggcaagga aacaagaggg gagcggccaa gtgccccgac   2340

caggaggccc cctacttcag aggcaagggc catgtggtcc tggcccccca ccccatccct   2400

tcccacctag gagctccccc tccacacagc ctccatctcc aggggaactt ggtgctacac   2460

gctggtgctc ttatcttcct ggggggaggg aggagggaag ggtggcccct cggggaaccc   2520

cctacctggg gctcctctaa agatggtgca gacacttcct gggcagtccc agctccccct   2580

gcccaccagg acccaccgtt ggctgccatc cagttggtac ccaagcacct gaagcctcaa   2640

agctggattc gctctagcat ccctcctctc ctgggtccac ttggccgtct cctccccacc   2700

gatcgctgtt ccccacatct ggggcgcttt tgggttggaa aaccacccca cactgggaat   2760

agccaccttg cccttgtaga atccatccgc ccatccgtcc attcatccat cggtccgtcc   2820

atccatgtcc ccagttgacc gcccggcacc actagctggc tgggtgcacc caccatcaac   2880

ctggttgacc tgtcatggcc gcctgtgccc tgcctccacc cccatcctac actcccccag   2940

ggcgtgcggg gctgtgcaga ctggggtgcc aggcatctcc tccccacccg gggtgtcccc   3000

acatgcagta ctgtataccc cccatccctc cctcggtcca ctgaacttca gagcagttcc   3060

cattcctgcc ccgcccatct ttttgtgtct cgctgtgata gatcaataaa tattttattt   3120

tttgtcctgg atatttgggg attatttttg attgttgata ttctcttttg gttttattgt   3180

tgtggttcat tgaaaaaaaa agataatttt tttttctgat ccggggagct gtatccccag   3240

tagaaaaaac attttaatca ctctaatata actctggatg aaacacacct ttttttttaa   3300

taagaaaaga gaattaactg cttcagaaat gactaataaa tgaaaaacct ttaaaggaaa   3360


<210>  3847
<211>  695
<212>  PRT
<213>  Homo sapiens

<400>  3847

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Ala Leu Gly Pro 
        35                  40                  45


Gly Gly Lys Pro Leu Lys Pro Val Pro Gly Gly Leu Ala Gly Ala Gly 
    50                  55                  60


Leu Gly Ala Gly Leu Gly Ala Phe Pro Ala Val Thr Phe Pro Gly Ala 
65                  70                  75                  80


Leu Val Pro Gly Gly Val Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala 
                85                  90                  95


Lys Ala Gly Ala Gly Leu Gly Gly Val Pro Gly Val Gly Gly Leu Gly 
            100                 105                 110


Val Ser Ala Gly Ala Val Val Pro Gln Pro Gly Ala Gly Val Lys Pro 
        115                 120                 125


Gly Lys Val Pro Gly Val Gly Leu Pro Gly Val Tyr Pro Gly Gly Val 
    130                 135                 140


Leu Pro Gly Ala Arg Phe Pro Gly Val Gly Val Leu Pro Gly Val Pro 
145                 150                 155                 160


Thr Gly Ala Gly Val Lys Pro Lys Ala Pro Gly Val Gly Gly Ala Phe 
                165                 170                 175


Ala Gly Ile Pro Gly Val Gly Pro Phe Gly Gly Pro Gln Pro Gly Val 
            180                 185                 190


Pro Leu Gly Tyr Pro Ile Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly 
        195                 200                 205


Leu Pro Tyr Thr Thr Gly Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly 
    210                 215                 220


Val Ala Gly Ala Ala Gly Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val 
225                 230                 235                 240


Gly Pro Gln Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe 
                245                 250                 255


Gly Ala Gly Ala Ala Gly Val Leu Pro Gly Val Gly Gly Ala Gly Val 
            260                 265                 270


Pro Gly Val Pro Gly Ala Ile Pro Gly Ile Gly Gly Ile Ala Gly Val 
        275                 280                 285


Gly Thr Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala 
    290                 295                 300


Lys Tyr Gly Ala Ala Ala Gly Leu Val Pro Gly Gly Pro Gly Phe Gly 
305                 310                 315                 320


Pro Gly Val Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
                325                 330                 335


Pro Gly Ala Gly Ile Pro Val Val Pro Gly Ala Gly Ile Pro Gly Ala 
            340                 345                 350


Ala Val Pro Gly Val Val Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala 
        355                 360                 365


Lys Ala Ala Lys Tyr Gly Ala Arg Pro Gly Val Gly Val Gly Gly Ile 
    370                 375                 380


Pro Thr Tyr Gly Val Gly Ala Gly Gly Phe Pro Gly Phe Gly Val Gly 
385                 390                 395                 400


Val Gly Gly Ile Pro Gly Val Ala Gly Val Pro Gly Val Gly Gly Val 
                405                 410                 415


Pro Gly Val Gly Gly Val Pro Gly Val Gly Ile Ser Pro Glu Ala Gln 
            420                 425                 430


Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Leu Val Pro Gly Val 
        435                 440                 445


Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro 
    450                 455                 460


Gly Val Gly Leu Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val 
465                 470                 475                 480


Ala Pro Gly Val Gly Val Ala Pro Gly Ile Gly Pro Gly Gly Val Ala 
                485                 490                 495


Ala Ala Ala Lys Ser Ala Ala Lys Val Ala Ala Lys Ala Gln Leu Arg 
            500                 505                 510


Ala Ala Ala Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly Val Gly Val 
        515                 520                 525


Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val Pro Gly Leu Gly Val 
    530                 535                 540


Gly Ala Gly Val Pro Gly Phe Gly Ala Val Pro Gly Ala Leu Ala Ala 
545                 550                 555                 560


Ala Lys Ala Ala Lys Tyr Gly Ala Ala Val Pro Gly Val Leu Gly Gly 
                565                 570                 575


Leu Gly Ala Leu Gly Gly Val Gly Ile Pro Gly Gly Val Val Gly Ala 
            580                 585                 590


Gly Pro Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala 
        595                 600                 605


Gln Phe Gly Leu Val Gly Ala Ala Gly Leu Gly Gly Leu Gly Val Gly 
    610                 615                 620


Gly Leu Gly Val Pro Gly Val Gly Gly Leu Gly Gly Ile Pro Pro Ala 
625                 630                 635                 640


Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Gly Leu Gly Gly Val 
                645                 650                 655


Leu Gly Gly Ala Gly Gln Phe Pro Leu Gly Gly Val Ala Ala Arg Pro 
            660                 665                 670


Gly Phe Gly Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys 
        675                 680                 685


Ala Cys Gly Arg Lys Arg Lys 
    690                 695


<210>  3848
<211>  3417
<212>  DNA
<213>  Homo sapiens

<400>  3848
ggcaacaatt aggctttggg gataaaacga ggtgcggaga gcgggctggg gcatttctcc     60

ccgagatggc gggtctgacg gcggcggccc cgcggcccgg agtcctcctg ctcctgctgt    120

ccatcctcca cccctctcgg cctggagggg tccctggggc cattcctggt ggagttcctg    180

gaggagtctt ttatccagcg ctggggcctg gaggcaaacc tcttaagcca gttcccggag    240

ggcttgcggg tgctggcctt ggggcagggc tcggcgcctt ccccgcagtt acctttccgg    300

gggctctggt gcctggtgga gtggctgacg ctgctgcagc ctataaagct gctaaggctg    360

gcgctgggct tggtggtgtc ccaggagttg gtggcttagg agtgtctgca ggtgcggtgg    420

ttcctcagcc tggagccgga gtgaagcctg ggaaagtgcc gggtgtgggg ctgccaggtg    480

tatacccagg tggcgtgctc ccaggagctc ggttccccgg tgtgggggtg ctccctggag    540

ttcccactgg agcaggagtt aagcccaagg ctccaggtgt aggtggagct tttgctggaa    600

tcccaggagt tggacccttt gggggaccgc aacctggagt cccactgggg tatcccatca    660

aggcccccaa gctgcctggt ggctatggac tgccctacac cacagggaaa ctgccctatg    720

gctatgggcc cggaggagtg gctggtgcag cgggcaaggc tggttaccca acagggacag    780

gggttggccc ccaggcagca gcagcagcgg cagctaaagc agcagcaaag ttcggtgctg    840

gagcagccgg agtcctccct ggtgttggag gggctggtgt tcctggcgtg cctggggcaa    900

ttcctggaat tggaggcatc gcaggcgttg ggactccagc tgcagctgca gctgcagcag    960

cagccgctaa ggcagccaag tatggagctg ctgcaggctt agtgcctggt gggccaggct   1020

ttggcccggg agtagttggt gtcccaggag ctggcgttcc aggtgttggt gtcccaggag   1080

ctgggattcc agttgtccca ggtgctggga tcccaggtgc tgcggttcca ggggttgtgt   1140

caccagaagc agctgctaag gcagctgcaa aggcagccaa atacggggcc aggcccggag   1200

tcggagttgg aggcattcct acttacgggg ttggagctgg gggctttccc ggctttggtg   1260

tcggagtcgg aggtatccct ggagtcgcag gtgtccctgg tgtcggaggt gttcccggag   1320

tcggaggtgt cccgggagtt ggcatttccc ccgaagctca ggcagcagct gccgccaagg   1380

ctgccaagta cggagtgggg accccagcag ctgcagctgc taaagcagcc gccaaagccg   1440

cccagtttgg gttagttcct ggtgtcggcg tggctcctgg agttggcgtg gctcctggtg   1500

tcggtgtggc tcctggagtt ggcttggctc ctggagttgg cgtggctcct ggagttggtg   1560

tggctcctgg cgttggcgtg gctcccggca ttggccctgg tggagttgca gctgcagcaa   1620

aatccgctgc caaggtggct gccaaagccc agctccgagc tgcagctggg cttggtgctg   1680

gcatccctgg acttggagtt ggtgtcggcg tccctggact tggagttggt gctggtgttc   1740

ctggacttgg agttggtgct ggtgttcctg gcttcggggc agtacctgga gccctggctg   1800

ccgctaaagc agccaaatat ggagcagcag tgcctggggt ccttggaggg ctcggggctc   1860

tcggtggagt aggcatccca ggcggtgtgg tgggagccgg acccgccgcc gccgctgccg   1920

cagccaaagc tgctgccaaa gccgcccagt ttggcctagt gggagccgct gggctcggag   1980

gactcggagt cggagggctt ggagttccag gtgttggggg ccttggaggt atacctccag   2040

ctgcagccgc taaagcagct aaatacggtg ctgctggcct tggaggtgtc ctagggggtg   2100

ccgggcagtt cccacttgga ggagtggcag caagacctgg cttcggattg tctcccattt   2160

tcccaggtgg ggcctgcctg gggaaagctt gtggccggaa gagaaaatga gcttcctagg   2220

acccctgact cacgacctca tcaacgttgg tgctactgct tggtggagaa tgtaaaccct   2280

ttgtaacccc atcccatgcc cctccgactc cccaccccag gagggaacgg gcaggccggg   2340

cggccttgca gatccacagg gcaaggaaac aagaggggag cggccaagtg ccccgaccag   2400

gaggccccct acttcagagg caagggccat gtggtcctgg ccccccaccc catcccttcc   2460

cacctaggag ctccccctcc acacagcctc catctccagg ggaacttggt gctacacgct   2520

ggtgctctta tcttcctggg gggagggagg agggaagggt ggcccctcgg ggaaccccct   2580

acctggggct cctctaaaga tggtgcagac acttcctggg cagtcccagc tccccctgcc   2640

caccaggacc caccgttggc tgccatccag ttggtaccca agcacctgaa gcctcaaagc   2700

tggattcgct ctagcatccc tcctctcctg ggtccacttg gccgtctcct ccccaccgat   2760

cgctgttccc cacatctggg gcgcttttgg gttggaaaac caccccacac tgggaatagc   2820

caccttgccc ttgtagaatc catccgccca tccgtccatt catccatcgg tccgtccatc   2880

catgtcccca gttgaccgcc cggcaccact agctggctgg gtgcacccac catcaacctg   2940

gttgacctgt catggccgcc tgtgccctgc ctccaccccc atcctacact cccccagggc   3000

gtgcggggct gtgcagactg gggtgccagg catctcctcc ccacccgggg tgtccccaca   3060

tgcagtactg tatacccccc atccctccct cggtccactg aacttcagag cagttcccat   3120

tcctgccccg cccatctttt tgtgtctcgc tgtgatagat caataaatat tttatttttt   3180

gtcctggata tttggggatt atttttgatt gttgatattc tcttttggtt ttattgttgt   3240

ggttcattga aaaaaaaaga taattttttt ttctgatccg gggagctgta tccccagtag   3300

aaaaaacatt ttaatcactc taatataact ctggatgaaa cacacctttt tttttaataa   3360

gaaaagagaa ttaactgctt cagaaatgac taataaatga aaaaccttta aaggaaa      3417


<210>  3849
<211>  714
<212>  PRT
<213>  Homo sapiens

<400>  3849

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Ala Leu Gly Pro 
        35                  40                  45


Gly Gly Lys Pro Leu Lys Pro Val Pro Gly Gly Leu Ala Gly Ala Gly 
    50                  55                  60


Leu Gly Ala Gly Leu Gly Ala Phe Pro Ala Val Thr Phe Pro Gly Ala 
65                  70                  75                  80


Leu Val Pro Gly Gly Val Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala 
                85                  90                  95


Lys Ala Gly Ala Gly Leu Gly Gly Val Pro Gly Val Gly Gly Leu Gly 
            100                 105                 110


Val Ser Ala Gly Ala Val Val Pro Gln Pro Gly Ala Gly Val Lys Pro 
        115                 120                 125


Gly Lys Val Pro Gly Val Gly Leu Pro Gly Val Tyr Pro Gly Gly Val 
    130                 135                 140


Leu Pro Gly Ala Arg Phe Pro Gly Val Gly Val Leu Pro Gly Val Pro 
145                 150                 155                 160


Thr Gly Ala Gly Val Lys Pro Lys Ala Pro Gly Val Gly Gly Ala Phe 
                165                 170                 175


Ala Gly Ile Pro Gly Val Gly Pro Phe Gly Gly Pro Gln Pro Gly Val 
            180                 185                 190


Pro Leu Gly Tyr Pro Ile Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly 
        195                 200                 205


Leu Pro Tyr Thr Thr Gly Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly 
    210                 215                 220


Val Ala Gly Ala Ala Gly Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val 
225                 230                 235                 240


Gly Pro Gln Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe 
                245                 250                 255


Gly Ala Gly Ala Ala Gly Val Leu Pro Gly Val Gly Gly Ala Gly Val 
            260                 265                 270


Pro Gly Val Pro Gly Ala Ile Pro Gly Ile Gly Gly Ile Ala Gly Val 
        275                 280                 285


Gly Thr Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala 
    290                 295                 300


Lys Tyr Gly Ala Ala Ala Gly Leu Val Pro Gly Gly Pro Gly Phe Gly 
305                 310                 315                 320


Pro Gly Val Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
                325                 330                 335


Pro Gly Ala Gly Ile Pro Val Val Pro Gly Ala Gly Ile Pro Gly Ala 
            340                 345                 350


Ala Val Pro Gly Val Val Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala 
        355                 360                 365


Lys Ala Ala Lys Tyr Gly Ala Arg Pro Gly Val Gly Val Gly Gly Ile 
    370                 375                 380


Pro Thr Tyr Gly Val Gly Ala Gly Gly Phe Pro Gly Phe Gly Val Gly 
385                 390                 395                 400


Val Gly Gly Ile Pro Gly Val Ala Gly Val Pro Gly Val Gly Gly Val 
                405                 410                 415


Pro Gly Val Gly Gly Val Pro Gly Val Gly Ile Ser Pro Glu Ala Gln 
            420                 425                 430


Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Val Gly Thr Pro Ala 
        435                 440                 445


Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe Gly Leu Val 
    450                 455                 460


Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly 
465                 470                 475                 480


Val Ala Pro Gly Val Gly Leu Ala Pro Gly Val Gly Val Ala Pro Gly 
                485                 490                 495


Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Ile Gly Pro Gly 
            500                 505                 510


Gly Val Ala Ala Ala Ala Lys Ser Ala Ala Lys Val Ala Ala Lys Ala 
        515                 520                 525


Gln Leu Arg Ala Ala Ala Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly 
    530                 535                 540


Val Gly Val Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val Pro Gly 
545                 550                 555                 560


Leu Gly Val Gly Ala Gly Val Pro Gly Phe Gly Ala Val Pro Gly Ala 
                565                 570                 575


Leu Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Val Pro Gly Val 
            580                 585                 590


Leu Gly Gly Leu Gly Ala Leu Gly Gly Val Gly Ile Pro Gly Gly Val 
        595                 600                 605


Val Gly Ala Gly Pro Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala 
    610                 615                 620


Lys Ala Ala Gln Phe Gly Leu Val Gly Ala Ala Gly Leu Gly Gly Leu 
625                 630                 635                 640


Gly Val Gly Gly Leu Gly Val Pro Gly Val Gly Gly Leu Gly Gly Ile 
                645                 650                 655


Pro Pro Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Gly Leu 
            660                 665                 670


Gly Gly Val Leu Gly Gly Ala Gly Gln Phe Pro Leu Gly Gly Val Ala 
        675                 680                 685


Ala Arg Pro Gly Phe Gly Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys 
    690                 695                 700


Leu Gly Lys Ala Cys Gly Arg Lys Arg Lys 
705                 710


<210>  3850
<211>  524
<212>  DNA
<213>  Homo sapiens

<400>  3850
gcaacaatta ggctttgggg ataaaacgag gtgcggagag cgggctgggg catttctccc     60

cgagatggcg ggtctgacgg cggcggcccc gcggcccgga gtcctcctgc tcctgctgtc    120

catcctccac ccctctcggc ctggaggggt ccctggggcc attcctggtg gagttcctgg    180

aggagtcttt tatccagggg ctggtctcgg agcccttgga ggaggagcgc tggggcctgg    240

aggcaaacct cttaagccag ttcccggagg gcttgcgggt gctggccttg gggcagggct    300

cggcgccttc cccgcagtta cctttccggg ggctctggtg cctggtggag tggctgacgc    360

tgctgcagcc tataaagctg ctaaggctgg tgagtggtgc tctttgggac atgccacaag    420

ccctctggct tccgtggggc cctccgcttt gcaaagaacc ttccctcaac tcaggcttgg    480

gagccgggtg ggtgggattg tcagttgcaa tctactgggg ctca                     524


<210>  3851
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  3851

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Glu Trp Cys 
            100                 105                 110


Ser Leu Gly His Ala Thr Ser Pro Leu Ala Ser Val Gly Pro Ser Ala 
        115                 120                 125


Leu Gln Arg Thr Phe Pro Gln Leu Arg Leu Gly Ser Arg Val Gly Gly 
    130                 135                 140


Ile Val Ser Cys Asn Leu Leu Gly 
145                 150


<210>  3852
<211>  1956
<212>  DNA
<213>  Homo sapiens

<400>  3852
aggctttggg gataaaacga ggtgcggaga gcgggctggg gcatttctcc ccgagatggc     60

gggtctgacg gcggcggccc cgcggcccgg agtcctcctg ctcctgctgt ccatcctcca    120

cccctctcgg cctggagggg tccctggggc cattcctggt ggagttcctg gaggagtctt    180

ttatccaggg gctggtctcg gagcccttgg aggaggagcg ctggggcctg gaggcaaacc    240

tcttaagcca gttcccggag ggcttgcggg tgctggcctt ggggcagggc tcggcgcctt    300

ccccgcagtt acctttccgg gggctctggt gcctggtgga gggtgctgga gcagccggag    360

tcctccctgg tgttggaggg gctggtgttc ctggcgtgcc tggggcaatt cctggaattg    420

gaggcatcgc aggcgttggg actccagctg cagctgcagc tgcagcagca gccgctaagg    480

cagccaagta tggagctgct gcaggcttag tgcctggtgg gccaggcttt ggcccgggag    540

tagttggtgt cccaggagct ggcgttccag gtgttggtgt cccaggagct gggattccag    600

ttgtcccagg tgctgggatc ccaggtgctg cggttccagg ggttgtgtca ccagaagcag    660

ctgctaaggc agctgcaaag gcagccaaat acggggccag gcccggagtc ggagttggag    720

gcattcctac ttacggggct ctcggtggag taggcatccc aggcggtgtg gtgggggcct    780

agtgggagcc gctgggctcg gaggactcgg agtcggaggg cttggagttc caggtgttgg    840

gggccttgga ggtatacctc cagctgcagc cgctaaagca gctaaatacg gagtggcagc    900

aagacctggc ttcggattgt ctcccatttt cccaggtggg gcctgcctgg ggaaagcttg    960

tggccggaag agaaaatgag cttcctagga cccctgactc acgacctcat caacgttggt   1020

gctactgctt ggtggagaat gtaaaccctt tgtaacccca tcccatgccc ctccgactcc   1080

ccaccccagg agggaacggg caggccgggc ggccttgcag atccacaggg caaggaaaca   1140

agaggggagc ggccaagtgc cccgaccagg aggcccccta cttcagaggc aagggccatg   1200

tggtcctggc cccccacccc atcccttccc acctaggagc tccccctcca cacagcctcc   1260

atctccaggg gaacttggtg ctacacgctg gtgctcttat cttcctgggg ggagggagga   1320

gggaagggtg gcccctcggg gaacccccta cctggggctc ctctaaagat ggtgcagaca   1380

cttcctgggc agtcccagct ccccctgccc accaggaccc accgttggct gccatccagt   1440

tggtacccaa gcacctgaag cctcaaagct ggattcgctc tagcatccct cctctcctgg   1500

gtccacttgg ccgtctcctc cccaccgatc gctgttcccc acatctgggg cgcttttggg   1560

ttggaaaacc accccacact gggaatagcc accttgccct tgtagaatcc atccgcccat   1620

ccgtccattc atccatcggt ccgtccatcc atgtccccag ttgaccgccc ggcaccacta   1680

gctggctggg tgcacccacc atcaacctgg ttgacctgtc atggccgcct gtgccctgcc   1740

tccaccccca tcctacactc ccccagggcg tgcggggctg tgcagactgg ggtgccaggc   1800

atctcctccc cacccggggt gtccccacat gcagtactgt atacccccca tccctccctc   1860

ggtccactga acttcagagc agttcccatt cctgccccgc ccatcttttt gtgtctcgct   1920

gtgatagatc aataaatatt ttattttttg tcctgg                             1956


<210>  3853
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  3853

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Gly 
                85                  90                  95


Cys Trp Ser Ser Arg Ser Pro Pro Trp Cys Trp Arg Gly Trp Cys Ser 
            100                 105                 110


Trp Arg Ala Trp Gly Asn Ser Trp Asn Trp Arg His Arg Arg Arg Trp 
        115                 120                 125


Asp Ser Ser Cys Ser Cys Ser Cys Ser Ser Ser Arg 
    130                 135                 140


<210>  3854
<211>  2186
<212>  DNA
<213>  Homo sapiens

<400>  3854
aggctttggg gataaaacga ggtgcggaga gcgggctggg gcatttctcc ccgagatggc     60

gggtctgacg gcggcggccc cgcggcccgg agtcctcctg ctcctgctgt ccatcctcca    120

cccctctcgg cctggagggg tccctggggc cattcctggt ggagttcctg gaggagtctt    180

ttatccaggg gctggtctcg gagcccttgg aggaggagcg ctggggcctg gaggcaaacc    240

tcttaagcca gttcccggag ggcttgcggg tgctggcctt ggggcagggc tcggcgcctt    300

ccccgcagtt acctttccgg gggctctggt gcctggtgga gggtgctgga gcagccggag    360

tcctccctgg tgttggaggg gctggtgttc ctggcgtgcc tggggcaatt cctggaattg    420

gaggcatcgc aggcgttggg actccagctg cagctgcagc tgcagcagca gccgctaagg    480

cagccaagta tggagctgct gcaggcttag tgcctggtgg gccaggcttt ggcccgggag    540

tagttggtgt cccaggagct ggcgttccag gtgttggtgt cccaggagct gggattccag    600

ttgtcccagg tgctgggatc ccaggtgctg cggttccagg ggttgtgtca ccagaagcag    660

ctgctaaggc agctgcaaag gcagccaaat acggggccag gcccggagtc ggagttggag    720

gcattcctac ttacggggct ctcggtggag taggcatccc aggcggtgtg gtgggggcct    780

agtgggagcc gctgggctcg gaggactcgg agtcggaggg cttggagttc caggtgttgg    840

gggccttgga ggtatacctc cagctgcagc cgctaaagca gctaaatacg gagtggcagc    900

aagacctggc ttcggattgt ctcccatttt cccaggtggg gcctgcctgg ggaaagcttg    960

tggccggaag agaaaatgag cttcctagga cccctgactc acgacctcat caacgttggt   1020

gctactgctt ggtggagaat gtaaaccctt tgtaacccca tcccatgccc ctccgactcc   1080

ccaccccagg agggaacggg caggccgggc ggccttgcag atccacaggg caaggaaaca   1140

agaggggagc ggccaagtgc cccgaccagg aggcccccta cttcagaggc aagggccatg   1200

tggtcctggc cccccacccc atcccttccc acctaggagc tccccctcca cacagcctcc   1260

atctccaggg gaacttggtg ctacacgctg gtgctcttat cttcctgggg ggagggagga   1320

gggaagggtg gcccctcggg gaacccccta cctggggctc ctctaaagat ggtgcagaca   1380

cttcctgggc agtcccagct ccccctgccc accaggaccc accgttggct gccatccagt   1440

tggtacccaa gcacctgaag cctcaaagct ggattcgctc tagcatccct cctctcctgg   1500

gtccacttgg ccgtctcctc cccaccgatc gctgttcccc acatctgggg cgcttttggg   1560

ttggaaaacc accccacact gggaatagcc accttgccct tgtagaatcc atccgcccat   1620

ccgtccattc atccatcggt ccgtccatcc atgtccccag ttgaccgccc ggcaccacta   1680

gctggctggg tgcacccacc atcaacctgg ttgacctgtc atggccgcct gtgccctgcc   1740

tccaccccca tcctacactc ccccagggcg tgcggggctg tgcagactgg ggtgccaggc   1800

atctcctccc cacccggggt gtccccacat gcagtactgt atacccccca tccctccctc   1860

ggtccactga acttcagagc agttcccatt cctgccccgc ccatcttttt gtgtctcgct   1920

gtgatagatc aataaatatt ttattttttg tcctggatat ttggggatta tttttgattg   1980

ttgatattct cttttggttt tattgttgtg gttcattgaa aaaaaaagat aatttttttt   2040

tctgatccgg ggagctgtat ccccagtaga aaaaacattt taatcactct aatataactc   2100

tggatgaaac acaccttttt ttttaataag aaaagagaat taactgcttc agaaatgact   2160

aataaatgaa aaacctttaa aggaaa                                        2186


<210>  3855
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  3855

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Gly 
                85                  90                  95


Cys Trp Ser Ser Arg Ser Pro Pro Trp Cys Trp Arg Gly Trp Cys Ser 
            100                 105                 110


Trp Arg Ala Trp Gly Asn Ser Trp Asn Trp Arg His Arg Arg Arg Trp 
        115                 120                 125


Asp Ser Ser Cys Ser Cys Ser Cys Ser Ser Ser Arg 
    130                 135                 140


<210>  3856
<211>  545
<212>  DNA
<213>  Homo sapiens

<400>  3856
ataaaacgag gtgcggagag cgggctgggg catttctccc cgagatggcg ggtctgacgg     60

cggcggcccc gcggcccgga gtcctcctgc tcctgctgtc catcctccac ccctctcggc    120

ctggaggggt ccctggggcc attcctggtg gagttcctgg aggagtcttt tatccagcgc    180

tggggcctgg aggcaaacct cttaagccag ttcccggagg gcttgcgggt gctggccttg    240

gggcagggct cggcgccttc cccgcagtta cctttccggg ggctctggtg cctggtggag    300

tggctgacgc tgctgcagcc tataaagctg ctaaggctgg cgctgggctt ggtggtgtcc    360

caggagttgg tggcttagga gtgtctgcag gtacgatggc tatccccgaa ctccctgggt    420

caaagttgca ggcctgggtg gagccaactc tgatgcagcc ccttctgtgc caggtgcggt    480

ggttcctcag cctggagccg gagtgaagcc tgggaaagtg ccgggtcagt gcggaatccc    540

tgggg                                                                545


<210>  3857
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  3857

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Ala Leu Gly Pro 
        35                  40                  45


Gly Gly Lys Pro Leu Lys Pro Val Pro Gly Gly Leu Ala Gly Ala Gly 
    50                  55                  60


Leu Gly Ala Gly Leu Gly Ala Phe Pro Ala Val Thr Phe Pro Gly Ala 
65                  70                  75                  80


Leu Val Pro Gly Gly Val Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala 
                85                  90                  95


Lys Ala Gly Ala Gly Leu Gly Gly Val Pro Gly Val Gly Gly Leu Gly 
            100                 105                 110


Val Ser Ala Gly Thr Met Ala Ile Pro Glu Leu Pro Gly Ser Lys Leu 
        115                 120                 125


Gln Ala Trp Val Glu Pro Thr Leu Met Gln Pro Leu Leu Cys Gln Val 
    130                 135                 140


Arg Trp Phe Leu Ser Leu Glu Pro Glu 
145                 150


<210>  3858
<211>  2864
<212>  DNA
<213>  Homo sapiens

<400>  3858
tgcggagagc gggctggggc atttctcccc gagatggcgg gtctgacggc ggcggccccg     60

cggcccggag tcctcctgct cctgctgtcc atcctccacc cctctcggcc tggaggggtc    120

cctggggcca ttcctggtgg agttcctgga ggagtctttt atccagcgct ggggcctgga    180

ggcaaacctc ttaagccagt tcccggaggg cttgcgggtg ctggccttgg ggcagggctc    240

ggcgccttcc ccgcagttac ctttccgggg gctctggtgc ctggtggagt ggctgacgct    300

gctgcagcct ataaagctgc taaggctggc gctgggcttg gtggtgtccc aggagttggt    360

ggcttaggag tgtctgcagg tgcggtggtt cctcagcctg gagccggagt gaagcctggg    420

aaagtgccgg gtgtggggct gccaggtgta tacccaggtg gcgtgctccc aggagttgga    480

ccctttgggg gaccgcaacc tggagtccca ctggggtatc ccatcaaggc ccccaagctg    540

cctggtggct atggactgcc ctacaccaca gggaaactgc cctatggcta tgggcccgga    600

ggagtggctg gtgcagcggg caaggctggt tacccaacag ggacaggggt tggcccccag    660

gcagcagcag cagcggcagc taaagcagca gcaaagttcg gtgctggagc agccggagtc    720

ctccctggtg ttggaggggc tggtgttcct ggcgtgcctg gggcaattcc tggaattgga    780

ggcatcgcag gcgttgggac tccagctgca gctgcagctg cagcagcagc cgctaaggca    840

gccaagtatg gagctgctgc aggcttagtg cctggtgggc caggctttgg cccgggagta    900

gttggtgtcc caggagctgg cgttccaggt gttggtgtcc caggagctgg gattccagtt    960

gtcccaggtg ctgggatccc aggtgctgcg gttccagggg ttgtgtcacc agaagcagct   1020

gctaaggcag ctgcaaaggc agccaaatac ggggccaggc ccggagtcgg agttggaggc   1080

attcctactt acggggttgg agctgggggc tttcccggct ttggtgtcgg agtcggagcc   1140

gaagctcagg cagcagctgc cgccaaggct gccaagtacg ggttagttcc tggtgtcggc   1200

gtggctcctg gagttggcgt ggctcctggt gtcggtgtgg ctcctggagt tggcttggct   1260

cctggagttg gcgtggctcc tggagttggt gtggctcctg gcgttggcgt ggctcccggc   1320

attggccctg gtggagttgc agctgcagca aaatccgctg ccaaggtggc tgccaaagcc   1380

cagctccgag ctgcagctgg gcttggtgct ggcatccctg gacttggagt tggtgtcggc   1440

gtccctggac ttggagttgg tgctggtgtt cctggacttg gagttggtgc tggtgttcct   1500

ggcttcgggg cagtacctgg agccctggct gccgctaaag cagccaaata tggagcagca   1560

gtgcctgggg tccttggagg gctcggggct ctcggtggag taggcatccc aggcggtgtg   1620

gtgggagccg gacccgccgc cgccgctgcc gcagccaaag ctgctgccaa agccgcccag   1680

tttggcctag tgggagccgc tgggctcgga ggactcggag tcggagggct tggagttcca   1740

ggtgttgggg gccttggagg tatacctcca gctgcagccg ctaaagcagc taaatacgga   1800

gtggcagcaa gacctggctt cggattgtct cccattttcc caggtggggc ctgcctgggg   1860

aaagcttgtg gccggaagag aaaatgagct tcctaggacc cctgactcac gacctcatca   1920

acgttggtgc tactgcttgg tggagaatgt aaaccctttg taaccccatc ccatgcccct   1980

ccgactcccc accccaggag ggaacgggca ggccgggcgg ccttgcagat ccacagggca   2040

aggaaacaag aggggagcgg ccaagtgccc cgaccaggag gccccctact tcagaggcaa   2100

gggccatgtg gtcctggccc cccaccccat cccttcccac ctaggagctc cccctccaca   2160

cagcctccat ctccagggga acttggtgct acacgctggt gctcttatct tcctgggggg   2220

agggaggagg gaagggtggc ccctcgggga accccctacc tggggctcct ctaaagatgg   2280

tgcagacact tcctgggcag tcccagctcc ccctgcccac caggacccac cgttggctgc   2340

catccagttg gtacccaagc acctgaagcc tcaaagctgg attcgctcta gcatccctcc   2400

tctcctgggt ccacttggcc gtctcctccc caccgatcgc tgttccccac atctggggcg   2460

cttttgggtt ggaaaaccac cccacactgg gaatagccac cttgcccttg tagaatccat   2520

ccgcccatcc gtccattcat ccatcggtcc gtccatccat gtccccagtt gaccgcccgg   2580

caccactagc tggctgggtg cacccaccat caacctggtt gacctgtcat ggccgcctgt   2640

gccctgcctc cacccccatc ctacactccc ccagggcgtg cggggctgtg cagactgggg   2700

tgccaggcat ctcctcccca cccggggtgt ccccacatgc agtactgtat accccccatc   2760

cctccctcgg tccactgaac ttcagagcag ttcccattcc tgccccgccc atctttttgt   2820

gtctcgctgt gatagatcaa taaatatttt attttttgtc ctgg                    2864


<210>  3859
<211>  617
<212>  PRT
<213>  Homo sapiens

<400>  3859

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Ala Leu Gly Pro 
        35                  40                  45


Gly Gly Lys Pro Leu Lys Pro Val Pro Gly Gly Leu Ala Gly Ala Gly 
    50                  55                  60


Leu Gly Ala Gly Leu Gly Ala Phe Pro Ala Val Thr Phe Pro Gly Ala 
65                  70                  75                  80


Leu Val Pro Gly Gly Val Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala 
                85                  90                  95


Lys Ala Gly Ala Gly Leu Gly Gly Val Pro Gly Val Gly Gly Leu Gly 
            100                 105                 110


Val Ser Ala Gly Ala Val Val Pro Gln Pro Gly Ala Gly Val Lys Pro 
        115                 120                 125


Gly Lys Val Pro Gly Val Gly Leu Pro Gly Val Tyr Pro Gly Gly Val 
    130                 135                 140


Leu Pro Gly Val Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro Leu 
145                 150                 155                 160


Gly Tyr Pro Ile Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu Pro 
                165                 170                 175


Tyr Thr Thr Gly Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly Val Ala 
            180                 185                 190


Gly Ala Ala Gly Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly Pro 
        195                 200                 205


Gln Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe Gly Ala 
    210                 215                 220


Gly Ala Ala Gly Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro Gly 
225                 230                 235                 240


Val Pro Gly Ala Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly Thr 
                245                 250                 255


Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr 
            260                 265                 270


Gly Ala Ala Ala Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro Gly 
        275                 280                 285


Val Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
    290                 295                 300


Ala Gly Ile Pro Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala Val 
305                 310                 315                 320


Pro Gly Val Val Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys Ala 
                325                 330                 335


Ala Lys Tyr Gly Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro Thr 
            340                 345                 350


Tyr Gly Val Gly Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val Gly 
        355                 360                 365


Ala Glu Ala Gln Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Leu 
    370                 375                 380


Val Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val 
385                 390                 395                 400


Gly Val Ala Pro Gly Val Gly Leu Ala Pro Gly Val Gly Val Ala Pro 
                405                 410                 415


Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Ile Gly Pro 
            420                 425                 430


Gly Gly Val Ala Ala Ala Ala Lys Ser Ala Ala Lys Val Ala Ala Lys 
        435                 440                 445


Ala Gln Leu Arg Ala Ala Ala Gly Leu Gly Ala Gly Ile Pro Gly Leu 
    450                 455                 460


Gly Val Gly Val Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val Pro 
465                 470                 475                 480


Gly Leu Gly Val Gly Ala Gly Val Pro Gly Phe Gly Ala Val Pro Gly 
                485                 490                 495


Ala Leu Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Val Pro Gly 
            500                 505                 510


Val Leu Gly Gly Leu Gly Ala Leu Gly Gly Val Gly Ile Pro Gly Gly 
        515                 520                 525


Val Val Gly Ala Gly Pro Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala 
    530                 535                 540


Ala Lys Ala Ala Gln Phe Gly Leu Val Gly Ala Ala Gly Leu Gly Gly 
545                 550                 555                 560


Leu Gly Val Gly Gly Leu Gly Val Pro Gly Val Gly Gly Leu Gly Gly 
                565                 570                 575


Ile Pro Pro Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Val Ala Ala 
            580                 585                 590


Arg Pro Gly Phe Gly Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys Leu 
        595                 600                 605


Gly Lys Ala Cys Gly Arg Lys Arg Lys 
    610                 615


<210>  3860
<211>  3094
<212>  DNA
<213>  Homo sapiens

<400>  3860
tgcggagagc gggctggggc atttctcccc gagatggcgg gtctgacggc ggcggccccg     60

cggcccggag tcctcctgct cctgctgtcc atcctccacc cctctcggcc tggaggggtc    120

cctggggcca ttcctggtgg agttcctgga ggagtctttt atccagcgct ggggcctgga    180

ggcaaacctc ttaagccagt tcccggaggg cttgcgggtg ctggccttgg ggcagggctc    240

ggcgccttcc ccgcagttac ctttccgggg gctctggtgc ctggtggagt ggctgacgct    300

gctgcagcct ataaagctgc taaggctggc gctgggcttg gtggtgtccc aggagttggt    360

ggcttaggag tgtctgcagg tgcggtggtt cctcagcctg gagccggagt gaagcctggg    420

aaagtgccgg gtgtggggct gccaggtgta tacccaggtg gcgtgctccc aggagttgga    480

ccctttgggg gaccgcaacc tggagtccca ctggggtatc ccatcaaggc ccccaagctg    540

cctggtggct atggactgcc ctacaccaca gggaaactgc cctatggcta tgggcccgga    600

ggagtggctg gtgcagcggg caaggctggt tacccaacag ggacaggggt tggcccccag    660

gcagcagcag cagcggcagc taaagcagca gcaaagttcg gtgctggagc agccggagtc    720

ctccctggtg ttggaggggc tggtgttcct ggcgtgcctg gggcaattcc tggaattgga    780

ggcatcgcag gcgttgggac tccagctgca gctgcagctg cagcagcagc cgctaaggca    840

gccaagtatg gagctgctgc aggcttagtg cctggtgggc caggctttgg cccgggagta    900

gttggtgtcc caggagctgg cgttccaggt gttggtgtcc caggagctgg gattccagtt    960

gtcccaggtg ctgggatccc aggtgctgcg gttccagggg ttgtgtcacc agaagcagct   1020

gctaaggcag ctgcaaaggc agccaaatac ggggccaggc ccggagtcgg agttggaggc   1080

attcctactt acggggttgg agctgggggc tttcccggct ttggtgtcgg agtcggagcc   1140

gaagctcagg cagcagctgc cgccaaggct gccaagtacg ggttagttcc tggtgtcggc   1200

gtggctcctg gagttggcgt ggctcctggt gtcggtgtgg ctcctggagt tggcttggct   1260

cctggagttg gcgtggctcc tggagttggt gtggctcctg gcgttggcgt ggctcccggc   1320

attggccctg gtggagttgc agctgcagca aaatccgctg ccaaggtggc tgccaaagcc   1380

cagctccgag ctgcagctgg gcttggtgct ggcatccctg gacttggagt tggtgtcggc   1440

gtccctggac ttggagttgg tgctggtgtt cctggacttg gagttggtgc tggtgttcct   1500

ggcttcgggg cagtacctgg agccctggct gccgctaaag cagccaaata tggagcagca   1560

gtgcctgggg tccttggagg gctcggggct ctcggtggag taggcatccc aggcggtgtg   1620

gtgggagccg gacccgccgc cgccgctgcc gcagccaaag ctgctgccaa agccgcccag   1680

tttggcctag tgggagccgc tgggctcgga ggactcggag tcggagggct tggagttcca   1740

ggtgttgggg gccttggagg tatacctcca gctgcagccg ctaaagcagc taaatacgga   1800

gtggcagcaa gacctggctt cggattgtct cccattttcc caggtggggc ctgcctgggg   1860

aaagcttgtg gccggaagag aaaatgagct tcctaggacc cctgactcac gacctcatca   1920

acgttggtgc tactgcttgg tggagaatgt aaaccctttg taaccccatc ccatgcccct   1980

ccgactcccc accccaggag ggaacgggca ggccgggcgg ccttgcagat ccacagggca   2040

aggaaacaag aggggagcgg ccaagtgccc cgaccaggag gccccctact tcagaggcaa   2100

gggccatgtg gtcctggccc cccaccccat cccttcccac ctaggagctc cccctccaca   2160

cagcctccat ctccagggga acttggtgct acacgctggt gctcttatct tcctgggggg   2220

agggaggagg gaagggtggc ccctcgggga accccctacc tggggctcct ctaaagatgg   2280

tgcagacact tcctgggcag tcccagctcc ccctgcccac caggacccac cgttggctgc   2340

catccagttg gtacccaagc acctgaagcc tcaaagctgg attcgctcta gcatccctcc   2400

tctcctgggt ccacttggcc gtctcctccc caccgatcgc tgttccccac atctggggcg   2460

cttttgggtt ggaaaaccac cccacactgg gaatagccac cttgcccttg tagaatccat   2520

ccgcccatcc gtccattcat ccatcggtcc gtccatccat gtccccagtt gaccgcccgg   2580

caccactagc tggctgggtg cacccaccat caacctggtt gacctgtcat ggccgcctgt   2640

gccctgcctc cacccccatc ctacactccc ccagggcgtg cggggctgtg cagactgggg   2700

tgccaggcat ctcctcccca cccggggtgt ccccacatgc agtactgtat accccccatc   2760

cctccctcgg tccactgaac ttcagagcag ttcccattcc tgccccgccc atctttttgt   2820

gtctcgctgt gatagatcaa taaatatttt attttttgtc ctggatattt ggggattatt   2880

tttgattgtt gatattctct tttggtttta ttgttgtggt tcattgaaaa aaaaagataa   2940

tttttttttc tgatccgggg agctgtatcc ccagtagaaa aaacatttta atcactctaa   3000

tataactctg gatgaaacac accttttttt ttaataagaa aagagaatta actgcttcag   3060

aaatgactaa taaatgaaaa acctttaaag gaaa                               3094


<210>  3861
<211>  617
<212>  PRT
<213>  Homo sapiens

<400>  3861

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Ala Leu Gly Pro 
        35                  40                  45


Gly Gly Lys Pro Leu Lys Pro Val Pro Gly Gly Leu Ala Gly Ala Gly 
    50                  55                  60


Leu Gly Ala Gly Leu Gly Ala Phe Pro Ala Val Thr Phe Pro Gly Ala 
65                  70                  75                  80


Leu Val Pro Gly Gly Val Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala 
                85                  90                  95


Lys Ala Gly Ala Gly Leu Gly Gly Val Pro Gly Val Gly Gly Leu Gly 
            100                 105                 110


Val Ser Ala Gly Ala Val Val Pro Gln Pro Gly Ala Gly Val Lys Pro 
        115                 120                 125


Gly Lys Val Pro Gly Val Gly Leu Pro Gly Val Tyr Pro Gly Gly Val 
    130                 135                 140


Leu Pro Gly Val Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro Leu 
145                 150                 155                 160


Gly Tyr Pro Ile Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu Pro 
                165                 170                 175


Tyr Thr Thr Gly Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly Val Ala 
            180                 185                 190


Gly Ala Ala Gly Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly Pro 
        195                 200                 205


Gln Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe Gly Ala 
    210                 215                 220


Gly Ala Ala Gly Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro Gly 
225                 230                 235                 240


Val Pro Gly Ala Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly Thr 
                245                 250                 255


Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr 
            260                 265                 270


Gly Ala Ala Ala Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro Gly 
        275                 280                 285


Val Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
    290                 295                 300


Ala Gly Ile Pro Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala Val 
305                 310                 315                 320


Pro Gly Val Val Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys Ala 
                325                 330                 335


Ala Lys Tyr Gly Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro Thr 
            340                 345                 350


Tyr Gly Val Gly Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val Gly 
        355                 360                 365


Ala Glu Ala Gln Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Leu 
    370                 375                 380


Val Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val 
385                 390                 395                 400


Gly Val Ala Pro Gly Val Gly Leu Ala Pro Gly Val Gly Val Ala Pro 
                405                 410                 415


Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Ile Gly Pro 
            420                 425                 430


Gly Gly Val Ala Ala Ala Ala Lys Ser Ala Ala Lys Val Ala Ala Lys 
        435                 440                 445


Ala Gln Leu Arg Ala Ala Ala Gly Leu Gly Ala Gly Ile Pro Gly Leu 
    450                 455                 460


Gly Val Gly Val Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val Pro 
465                 470                 475                 480


Gly Leu Gly Val Gly Ala Gly Val Pro Gly Phe Gly Ala Val Pro Gly 
                485                 490                 495


Ala Leu Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Val Pro Gly 
            500                 505                 510


Val Leu Gly Gly Leu Gly Ala Leu Gly Gly Val Gly Ile Pro Gly Gly 
        515                 520                 525


Val Val Gly Ala Gly Pro Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala 
    530                 535                 540


Ala Lys Ala Ala Gln Phe Gly Leu Val Gly Ala Ala Gly Leu Gly Gly 
545                 550                 555                 560


Leu Gly Val Gly Gly Leu Gly Val Pro Gly Val Gly Gly Leu Gly Gly 
                565                 570                 575


Ile Pro Pro Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Val Ala Ala 
            580                 585                 590


Arg Pro Gly Phe Gly Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys Leu 
        595                 600                 605


Gly Lys Ala Cys Gly Arg Lys Arg Lys 
    610                 615


<210>  3862
<211>  2886
<212>  DNA
<213>  Homo sapiens

<400>  3862
gcatttctcc ccgagatggc gggtctgacg gcggcggccc cgcggcccgg agtcctcctg     60

ctcctgctgt ccatcctcca cccctctcgg cctggagggg tccctggggc cattcctggt    120

ggagttcctg gaggagtctt ttatccaggg gctggtctcg gagcccttgg aggaggagcg    180

ctggggcctg gaggcaaacc tcttaagcca gttcccggag ggcttgcggg tgctggcctt    240

ggggcaggcg ctgggcttgg tggtgtccca ggagttggtg gcttaggagt gtctgcaggt    300

gcggtggttc ctcagcctgg agccggagtg aagcctggga aagtgccggg tgtggggctg    360

ccaggtgtat acccaggtgg cgtgctccca ggagctcggt tccccggtgt gggggtgctc    420

cctggagttc ccactggagc aggagttaag cccaaggctc caggtgtagg tggagctttt    480

gctggaatcc caggagttgg accctttggg ggaccgcaac ctggagtccc actggggtat    540

cccatcaagg cccccaagct gcctggtggc tatggactgc cctacaccac agggaaactg    600

ccctatggct atgggcccgg aggagtggct ggtgcagcgg gcaaggctgg ttacccaaca    660

gggacagggg ttggccccca gggtgctgga gcagccggag tcctccctgg tgttggaggg    720

gctggtgttc ctggcgtgcc tggggcaatt cctggaattg gaggcatcgc aggcgttggg    780

actccagctg cagctgcagc tgcagcagca gccgctaagg cagccaagta tggagctgct    840

gcaggcttag tgcctggtgg gccaggcttt ggcccgggag tagttggtgt cccaggagct    900

ggcgttccag gtgttggtgt cccaggagct gggattccag ttgtcccagg tgctgggatc    960

ccaggtgctg cggttccagg ggttgtgtca ccagaagcag ctgctaaggc agctgcaaag   1020

gcagccaaat acggggccag gcccggagtc ggagttggag gcattcctac ttacggggtt   1080

ggagctgggg gctttcccgg ctttggtgtc ggagtcggag gtatccctgg agtcgcaggt   1140

gtccctggtg tcggaggtgt tcccggagtc ggaggtgtcc cgggagttgg catttccccc   1200

gaagctcagg cagcagctgc cgccaaggct gccaagtacg gagtggggac cccagcagct   1260

gcagctgcta aagcagccgc caaagccgcc cagtttggta agctcctgga gttggtgtgg   1320

ctcctggcgt tggcgtggct cccggcattg gccctggtgg agttgcagct gcagcaaaat   1380

ccgctgccaa ggtggctgcc aaagcccagc tccgagctgc agctgggctt ggtgctggca   1440

tccctggact tggagttggt gtcggcgtcc ctggacttgg agttggtgct ggtgttcctg   1500

gacttggagt tggtgctggt gttcctggct tcggggcagt acctggagcc ctggctgccg   1560

ctaaagcagc caaatatgga gcagcagtgc ctggggtcct tggagggctc ggggctctcg   1620

gtggagtagg catcccaggc ggtgtggtgg gggcctagtg ggagccgctg ggctcggagg   1680

actcggagtc ggagggcttg gagttccagg tgttgggggc cttggaggta tacctccagc   1740

tgcagccgct aaagcagcta aatacggtgc tgctggcctt ggaggtgtcc tagggggtgc   1800

cgggcagttc ccacttggag gagtggcagc aagacctggc ttcggattgt ctcccatttt   1860

cccaggtggg gcctgcctgg ggaaagcttg tggccggaag agaaaatgag cttcctagga   1920

cccctgactc acgacctcat caacgttggt gctactgctt ggtggagaat gtaaaccctt   1980

tgtaacccca tcccatgccc ctccgactcc ccaccccagg agggaacggg caggccgggc   2040

ggccttgcag atccacaggg caaggaaaca agaggggagc ggccaagtgc cccgaccagg   2100

aggcccccta cttcagaggc aagggccatg tggtcctggc cccccacccc atcccttccc   2160

acctaggagc tccccctcca cacagcctcc atctccaggg gaacttggtg ctacacgctg   2220

gtgctcttat cttcctgggg ggagggagga gggaagggtg gcccctcggg gaacccccta   2280

cctggggctc ctctaaagat ggtgcagaca cttcctgggc agtcccagct ccccctgccc   2340

accaggaccc accgttggct gccatccagt tggtacccaa gcacctgaag cctcaaagct   2400

ggattcgctc tagcatccct cctctcctgg gtccacttgg ccgtctcctc cccaccgatc   2460

gctgttcccc acatctgggg cgcttttggg ttggaaaacc accccacact gggaatagcc   2520

accttgccct tgtagaatcc atccgcccat ccgtccattc atccatcggt ccgtccatcc   2580

atgtccccag ttgaccgccc ggcaccacta gctggctggg tgcacccacc atcaacctgg   2640

ttgacctgtc atggccgcct gtgccctgcc tccaccccca tcctacactc ccccagggcg   2700

tgcggggctg tgcagactgg ggtgccaggc atctcctccc cacccggggt gtccccacat   2760

gcagtactgt atacccccca tccctccctc ggtccactga acttcagagc agttcccatt   2820

cctgccccgc ccatcttttt gtgtctcgct gtgatagatc aataaatatt ttattttttg   2880

tcctgg                                                              2886


<210>  3863
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  3863

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Ala Gly 
65                  70                  75                  80


Leu Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala 
                85                  90                  95


Val Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly 
            100                 105                 110


Val Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro Gly Ala Arg 
        115                 120                 125


Phe Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly Ala Gly Val 
    130                 135                 140


Lys Pro Lys Ala Pro Gly Val Gly Gly Ala Phe Ala Gly Ile Pro Gly 
145                 150                 155                 160


Val Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro Leu Gly Tyr Pro 
                165                 170                 175


Ile Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu Pro Tyr Thr Thr 
            180                 185                 190


Gly Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala 
        195                 200                 205


Gly Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly Pro Gln Gly Ala 
    210                 215                 220


Gly Ala Ala Gly Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro Gly 
225                 230                 235                 240


Val Pro Gly Ala Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly Thr 
                245                 250                 255


Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr 
            260                 265                 270


Gly Ala Ala Ala Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro Gly 
        275                 280                 285


Val Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
    290                 295                 300


Ala Gly Ile Pro Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala Val 
305                 310                 315                 320


Pro Gly Val Val Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys Ala 
                325                 330                 335


Ala Lys Tyr Gly Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro Thr 
            340                 345                 350


Tyr Gly Val Gly Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val Gly 
        355                 360                 365


Gly Ile Pro Gly Val Ala Gly Val Pro Gly Val Gly Gly Val Pro Gly 
    370                 375                 380


Val Gly Gly Val Pro Gly Val Gly Ile Ser Pro Glu Ala Gln Ala Ala 
385                 390                 395                 400


Ala Ala Ala Lys Ala Ala Lys Tyr Gly Val Gly Thr Pro Ala Ala Ala 
                405                 410                 415


Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe Gly Lys Leu Leu Glu 
            420                 425                 430


Leu Val Trp Leu Leu Ala Leu Ala Trp Leu Pro Ala Leu Ala Leu Val 
        435                 440                 445


Glu Leu Gln Leu Gln Gln Asn Pro Leu Pro Arg Trp Leu Pro Lys Pro 
    450                 455                 460


Ser Ser Glu Leu Gln Leu Gly Leu Val Leu Ala Ser Leu Asp Leu Glu 
465                 470                 475                 480


Leu Val Ser Ala Ser Leu Asp Leu Glu Leu Val Leu Val Phe Leu Asp 
                485                 490                 495


Leu Glu Leu Val Leu Val Phe Leu Ala Ser Gly Gln Tyr Leu Glu Pro 
            500                 505                 510


Trp Leu Pro Leu Lys Gln Pro Asn Met Glu Gln Gln Cys Leu Gly Ser 
        515                 520                 525


Leu Glu Gly Ser Gly Leu Ser Val Glu 
    530                 535


<210>  3864
<211>  3116
<212>  DNA
<213>  Homo sapiens

<400>  3864
gcatttctcc ccgagatggc gggtctgacg gcggcggccc cgcggcccgg agtcctcctg     60

ctcctgctgt ccatcctcca cccctctcgg cctggagggg tccctggggc cattcctggt    120

ggagttcctg gaggagtctt ttatccaggg gctggtctcg gagcccttgg aggaggagcg    180

ctggggcctg gaggcaaacc tcttaagcca gttcccggag ggcttgcggg tgctggcctt    240

ggggcaggcg ctgggcttgg tggtgtccca ggagttggtg gcttaggagt gtctgcaggt    300

gcggtggttc ctcagcctgg agccggagtg aagcctggga aagtgccggg tgtggggctg    360

ccaggtgtat acccaggtgg cgtgctccca ggagctcggt tccccggtgt gggggtgctc    420

cctggagttc ccactggagc aggagttaag cccaaggctc caggtgtagg tggagctttt    480

gctggaatcc caggagttgg accctttggg ggaccgcaac ctggagtccc actggggtat    540

cccatcaagg cccccaagct gcctggtggc tatggactgc cctacaccac agggaaactg    600

ccctatggct atgggcccgg aggagtggct ggtgcagcgg gcaaggctgg ttacccaaca    660

gggacagggg ttggccccca gggtgctgga gcagccggag tcctccctgg tgttggaggg    720

gctggtgttc ctggcgtgcc tggggcaatt cctggaattg gaggcatcgc aggcgttggg    780

actccagctg cagctgcagc tgcagcagca gccgctaagg cagccaagta tggagctgct    840

gcaggcttag tgcctggtgg gccaggcttt ggcccgggag tagttggtgt cccaggagct    900

ggcgttccag gtgttggtgt cccaggagct gggattccag ttgtcccagg tgctgggatc    960

ccaggtgctg cggttccagg ggttgtgtca ccagaagcag ctgctaaggc agctgcaaag   1020

gcagccaaat acggggccag gcccggagtc ggagttggag gcattcctac ttacggggtt   1080

ggagctgggg gctttcccgg ctttggtgtc ggagtcggag gtatccctgg agtcgcaggt   1140

gtccctggtg tcggaggtgt tcccggagtc ggaggtgtcc cgggagttgg catttccccc   1200

gaagctcagg cagcagctgc cgccaaggct gccaagtacg gagtggggac cccagcagct   1260

gcagctgcta aagcagccgc caaagccgcc cagtttggta agctcctgga gttggtgtgg   1320

ctcctggcgt tggcgtggct cccggcattg gccctggtgg agttgcagct gcagcaaaat   1380

ccgctgccaa ggtggctgcc aaagcccagc tccgagctgc agctgggctt ggtgctggca   1440

tccctggact tggagttggt gtcggcgtcc ctggacttgg agttggtgct ggtgttcctg   1500

gacttggagt tggtgctggt gttcctggct tcggggcagt acctggagcc ctggctgccg   1560

ctaaagcagc caaatatgga gcagcagtgc ctggggtcct tggagggctc ggggctctcg   1620

gtggagtagg catcccaggc ggtgtggtgg gggcctagtg ggagccgctg ggctcggagg   1680

actcggagtc ggagggcttg gagttccagg tgttgggggc cttggaggta tacctccagc   1740

tgcagccgct aaagcagcta aatacggtgc tgctggcctt ggaggtgtcc tagggggtgc   1800

cgggcagttc ccacttggag gagtggcagc aagacctggc ttcggattgt ctcccatttt   1860

cccaggtggg gcctgcctgg ggaaagcttg tggccggaag agaaaatgag cttcctagga   1920

cccctgactc acgacctcat caacgttggt gctactgctt ggtggagaat gtaaaccctt   1980

tgtaacccca tcccatgccc ctccgactcc ccaccccagg agggaacggg caggccgggc   2040

ggccttgcag atccacaggg caaggaaaca agaggggagc ggccaagtgc cccgaccagg   2100

aggcccccta cttcagaggc aagggccatg tggtcctggc cccccacccc atcccttccc   2160

acctaggagc tccccctcca cacagcctcc atctccaggg gaacttggtg ctacacgctg   2220

gtgctcttat cttcctgggg ggagggagga gggaagggtg gcccctcggg gaacccccta   2280

cctggggctc ctctaaagat ggtgcagaca cttcctgggc agtcccagct ccccctgccc   2340

accaggaccc accgttggct gccatccagt tggtacccaa gcacctgaag cctcaaagct   2400

ggattcgctc tagcatccct cctctcctgg gtccacttgg ccgtctcctc cccaccgatc   2460

gctgttcccc acatctgggg cgcttttggg ttggaaaacc accccacact gggaatagcc   2520

accttgccct tgtagaatcc atccgcccat ccgtccattc atccatcggt ccgtccatcc   2580

atgtccccag ttgaccgccc ggcaccacta gctggctggg tgcacccacc atcaacctgg   2640

ttgacctgtc atggccgcct gtgccctgcc tccaccccca tcctacactc ccccagggcg   2700

tgcggggctg tgcagactgg ggtgccaggc atctcctccc cacccggggt gtccccacat   2760

gcagtactgt atacccccca tccctccctc ggtccactga acttcagagc agttcccatt   2820

cctgccccgc ccatcttttt gtgtctcgct gtgatagatc aataaatatt ttattttttg   2880

tcctggatat ttggggatta tttttgattg ttgatattct cttttggttt tattgttgtg   2940

gttcattgaa aaaaaaagat aatttttttt tctgatccgg ggagctgtat ccccagtaga   3000

aaaaacattt taatcactct aatataactc tggatgaaac acaccttttt ttttaataag   3060

aaaagagaat taactgcttc agaaatgact aataaatgaa aaacctttaa aggaaa       3116


<210>  3865
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  3865

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Ala Gly 
65                  70                  75                  80


Leu Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala 
                85                  90                  95


Val Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly 
            100                 105                 110


Val Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro Gly Ala Arg 
        115                 120                 125


Phe Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly Ala Gly Val 
    130                 135                 140


Lys Pro Lys Ala Pro Gly Val Gly Gly Ala Phe Ala Gly Ile Pro Gly 
145                 150                 155                 160


Val Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro Leu Gly Tyr Pro 
                165                 170                 175


Ile Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu Pro Tyr Thr Thr 
            180                 185                 190


Gly Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala 
        195                 200                 205


Gly Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly Pro Gln Gly Ala 
    210                 215                 220


Gly Ala Ala Gly Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro Gly 
225                 230                 235                 240


Val Pro Gly Ala Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly Thr 
                245                 250                 255


Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr 
            260                 265                 270


Gly Ala Ala Ala Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro Gly 
        275                 280                 285


Val Val Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
    290                 295                 300


Ala Gly Ile Pro Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala Val 
305                 310                 315                 320


Pro Gly Val Val Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys Ala 
                325                 330                 335


Ala Lys Tyr Gly Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro Thr 
            340                 345                 350


Tyr Gly Val Gly Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val Gly 
        355                 360                 365


Gly Ile Pro Gly Val Ala Gly Val Pro Gly Val Gly Gly Val Pro Gly 
    370                 375                 380


Val Gly Gly Val Pro Gly Val Gly Ile Ser Pro Glu Ala Gln Ala Ala 
385                 390                 395                 400


Ala Ala Ala Lys Ala Ala Lys Tyr Gly Val Gly Thr Pro Ala Ala Ala 
                405                 410                 415


Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe Gly Lys Leu Leu Glu 
            420                 425                 430


Leu Val Trp Leu Leu Ala Leu Ala Trp Leu Pro Ala Leu Ala Leu Val 
        435                 440                 445


Glu Leu Gln Leu Gln Gln Asn Pro Leu Pro Arg Trp Leu Pro Lys Pro 
    450                 455                 460


Ser Ser Glu Leu Gln Leu Gly Leu Val Leu Ala Ser Leu Asp Leu Glu 
465                 470                 475                 480


Leu Val Ser Ala Ser Leu Asp Leu Glu Leu Val Leu Val Phe Leu Asp 
                485                 490                 495


Leu Glu Leu Val Leu Val Phe Leu Ala Ser Gly Gln Tyr Leu Glu Pro 
            500                 505                 510


Trp Leu Pro Leu Lys Gln Pro Asn Met Glu Gln Gln Cys Leu Gly Ser 
        515                 520                 525


Leu Glu Gly Ser Gly Leu Ser Val Glu 
    530                 535


<210>  3866
<211>  2703
<212>  DNA
<213>  Homo sapiens

<400>  3866
atttctcccc gagatggcgg gtctgacggc ggcggccccg cggcccggag tcctcctgct     60

cctgctgtcc atcctccacc cctctcggcc tggaggggtc cctggggcca ttcctggtgg    120

agttcctgga ggagtctttt atccaggggc tggtctcgga gcccttggag gaggagcgct    180

ggggcctgga ggcaaacctc ttaagccagt tcccggaggg cttgcgggtg ctggccttgg    240

ggcaggtgta ggtggagctt ttgctggaat cccaggagtt ggaccctttg ggggaccgca    300

acctggagtc ccactggggt atcccatcaa ggcccccaag ctgcctggct atgggcccgg    360

aggagtggct ggtgcagcgg gcaaggctgg ttacccaaca gggacagggg ttggccccca    420

ggcagcagca gcagcggcag ctaaagcagc agcaaagttc ggtgctggag cagccggagt    480

cctccctggt gttggagggg ctggtgttcc tggcgtgcct ggggcaattc ctggaattgg    540

aggcatcgca ggcgttggga ctccagctgc agctgcagct gcagcagcag ccgctaaggc    600

agccaagtat ggagctgctg caggcttagt gcctggtggg ccaggctttg gcccgggagt    660

agttggtgtc ccaggagctg gcgttccagg tgttggtgtc ccaggagctg ggattccagt    720

tgtcccaggt gctgggatcc caggtgctgc ggttccaggg gttgtgtcac cagaagcagc    780

tgctaaggca gctgcaaagg cagccaaata cggggccagg cccggagtcg gagttggagg    840

cattcctact tacggggttg gagctggggg ctttcccggc tttggtgtcg gagtcggagg    900

tatccctgga gtcgcaggtg tccctggtgt cggaggtgtt cccggagtcg gaggtgtccc    960

gggagttggc atttcccccg aagctcaggc agcagctgcc gccaaggctg ccaagtacgg   1020

gttagttcct ggtgtcggcg tggctcctgg agttggcgtg gctcctggtg tcggtgtggc   1080

tcctggagtt ggcttggctc ctggagttgg cgtggctcct ggagttggtg tggctcctgg   1140

cgttggcgtg gctcccggca ttggccctgg tggagttgca gctgcagcaa aatccgctgc   1200

caaggtggct gccaaagccc agctccgagc tgcagctggg cttggtgctg gcatccctgg   1260

acttggagtt ggtgtcggcg tccctggact tggagttggt gctggtgttc ctggacttgg   1320

agttggtgct ggtgttcctg gcttcggggc agtacctgga gccctggctg ccgctaaagc   1380

agccaaatat ggagcagcag tgcctggggt ccttggaggg ctcggggctc tcggtggagt   1440

aggcatccca ggcggtgtgg tgggagccgg acccgccgcc gccgctgccg cagccaaagc   1500

tgctgccaaa gccgcccagt ttggcctagt gggagccgct gggctcggag gactcggagt   1560

cggagggctt ggagttccag gtgttggggg ccttggaggt atacctccag ctgcagccgc   1620

taaagcagct aaatacggag tggcagcaag acctggcttc ggattgtctc ccattttccc   1680

aggtggggcc tgcctgggga aagcttgtgg ccggaagaga aaatgagctt cctaggaccc   1740

ctgactcacg acctcatcaa cgttggtgct actgcttggt ggagaatgta aaccctttgt   1800

aaccccatcc catgcccctc cgactcccca ccccaggagg gaacgggcag gccgggcggc   1860

cttgcagatc cacagggcaa ggaaacaaga ggggagcggc caagtgcccc gaccaggagg   1920

ccccctactt cagaggcaag ggccatgtgg tcctggcccc ccaccccatc ccttcccacc   1980

taggagctcc ccctccacac agcctccatc tccaggggaa cttggtgcta cacgctggtg   2040

ctcttatctt cctgggggga gggaggaggg aagggtggcc cctcggggaa ccccctacct   2100

ggggctcctc taaagatggt gcagacactt cctgggcagt cccagctccc cctgcccacc   2160

aggacccacc gttggctgcc atccagttgg tacccaagca cctgaagcct caaagctgga   2220

ttcgctctag catccctcct ctcctgggtc cacttggccg tctcctcccc accgatcgct   2280

gttccccaca tctggggcgc ttttgggttg gaaaaccacc ccacactggg aatagccacc   2340

ttgcccttgt agaatccatc cgcccatccg tccattcatc catcggtccg tccatccatg   2400

tccccagttg accgcccggc accactagct ggctgggtgc acccaccatc aacctggttg   2460

acctgtcatg gccgcctgtg ccctgcctcc acccccatcc tacactcccc cagggcgtgc   2520

ggggctgtgc agactggggt gccaggcatc tcctccccac ccggggtgtc cccacatgca   2580

gtactgtata ccccccatcc ctccctcggt ccactgaact tcagagcagt tcccattcct   2640

gccccgccca tctttttgtg tctcgctgtg atagatcaat aaatatttta ttttttgtcc   2700

tgg                                                                 2703


<210>  3867
<211>  570
<212>  PRT
<213>  Homo sapiens

<400>  3867

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Val Gly 
65                  70                  75                  80


Gly Ala Phe Ala Gly Ile Pro Gly Val Gly Pro Phe Gly Gly Pro Gln 
                85                  90                  95


Pro Gly Val Pro Leu Gly Tyr Pro Ile Lys Ala Pro Lys Leu Pro Gly 
            100                 105                 110


Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala Gly Lys Ala Gly Tyr Pro 
        115                 120                 125


Thr Gly Thr Gly Val Gly Pro Gln Ala Ala Ala Ala Ala Ala Ala Lys 
    130                 135                 140


Ala Ala Ala Lys Phe Gly Ala Gly Ala Ala Gly Val Leu Pro Gly Val 
145                 150                 155                 160


Gly Gly Ala Gly Val Pro Gly Val Pro Gly Ala Ile Pro Gly Ile Gly 
                165                 170                 175


Gly Ile Ala Gly Val Gly Thr Pro Ala Ala Ala Ala Ala Ala Ala Ala 
            180                 185                 190


Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Ala Gly Leu Val Pro Gly 
        195                 200                 205


Gly Pro Gly Phe Gly Pro Gly Val Val Gly Val Pro Gly Ala Gly Val 
    210                 215                 220


Pro Gly Val Gly Val Pro Gly Ala Gly Ile Pro Val Val Pro Gly Ala 
225                 230                 235                 240


Gly Ile Pro Gly Ala Ala Val Pro Gly Val Val Ser Pro Glu Ala Ala 
                245                 250                 255


Ala Lys Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Arg Pro Gly Val 
            260                 265                 270


Gly Val Gly Gly Ile Pro Thr Tyr Gly Val Gly Ala Gly Gly Phe Pro 
        275                 280                 285


Gly Phe Gly Val Gly Val Gly Gly Ile Pro Gly Val Ala Gly Val Pro 
    290                 295                 300


Gly Val Gly Gly Val Pro Gly Val Gly Gly Val Pro Gly Val Gly Ile 
305                 310                 315                 320


Ser Pro Glu Ala Gln Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly 
                325                 330                 335


Leu Val Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly 
            340                 345                 350


Val Gly Val Ala Pro Gly Val Gly Leu Ala Pro Gly Val Gly Val Ala 
        355                 360                 365


Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Ile Gly 
    370                 375                 380


Pro Gly Gly Val Ala Ala Ala Ala Lys Ser Ala Ala Lys Val Ala Ala 
385                 390                 395                 400


Lys Ala Gln Leu Arg Ala Ala Ala Gly Leu Gly Ala Gly Ile Pro Gly 
                405                 410                 415


Leu Gly Val Gly Val Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val 
            420                 425                 430


Pro Gly Leu Gly Val Gly Ala Gly Val Pro Gly Phe Gly Ala Val Pro 
        435                 440                 445


Gly Ala Leu Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Val Pro 
    450                 455                 460


Gly Val Leu Gly Gly Leu Gly Ala Leu Gly Gly Val Gly Ile Pro Gly 
465                 470                 475                 480


Gly Val Val Gly Ala Gly Pro Ala Ala Ala Ala Ala Ala Ala Lys Ala 
                485                 490                 495


Ala Ala Lys Ala Ala Gln Phe Gly Leu Val Gly Ala Ala Gly Leu Gly 
            500                 505                 510


Gly Leu Gly Val Gly Gly Leu Gly Val Pro Gly Val Gly Gly Leu Gly 
        515                 520                 525


Gly Ile Pro Pro Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Val Ala 
    530                 535                 540


Ala Arg Pro Gly Phe Gly Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys 
545                 550                 555                 560


Leu Gly Lys Ala Cys Gly Arg Lys Arg Lys 
                565                 570


<210>  3868
<211>  2933
<212>  DNA
<213>  Homo sapiens

<400>  3868
atttctcccc gagatggcgg gtctgacggc ggcggccccg cggcccggag tcctcctgct     60

cctgctgtcc atcctccacc cctctcggcc tggaggggtc cctggggcca ttcctggtgg    120

agttcctgga ggagtctttt atccaggggc tggtctcgga gcccttggag gaggagcgct    180

ggggcctgga ggcaaacctc ttaagccagt tcccggaggg cttgcgggtg ctggccttgg    240

ggcaggtgta ggtggagctt ttgctggaat cccaggagtt ggaccctttg ggggaccgca    300

acctggagtc ccactggggt atcccatcaa ggcccccaag ctgcctggct atgggcccgg    360

aggagtggct ggtgcagcgg gcaaggctgg ttacccaaca gggacagggg ttggccccca    420

ggcagcagca gcagcggcag ctaaagcagc agcaaagttc ggtgctggag cagccggagt    480

cctccctggt gttggagggg ctggtgttcc tggcgtgcct ggggcaattc ctggaattgg    540

aggcatcgca ggcgttggga ctccagctgc agctgcagct gcagcagcag ccgctaaggc    600

agccaagtat ggagctgctg caggcttagt gcctggtggg ccaggctttg gcccgggagt    660

agttggtgtc ccaggagctg gcgttccagg tgttggtgtc ccaggagctg ggattccagt    720

tgtcccaggt gctgggatcc caggtgctgc ggttccaggg gttgtgtcac cagaagcagc    780

tgctaaggca gctgcaaagg cagccaaata cggggccagg cccggagtcg gagttggagg    840

cattcctact tacggggttg gagctggggg ctttcccggc tttggtgtcg gagtcggagg    900

tatccctgga gtcgcaggtg tccctggtgt cggaggtgtt cccggagtcg gaggtgtccc    960

gggagttggc atttcccccg aagctcaggc agcagctgcc gccaaggctg ccaagtacgg   1020

gttagttcct ggtgtcggcg tggctcctgg agttggcgtg gctcctggtg tcggtgtggc   1080

tcctggagtt ggcttggctc ctggagttgg cgtggctcct ggagttggtg tggctcctgg   1140

cgttggcgtg gctcccggca ttggccctgg tggagttgca gctgcagcaa aatccgctgc   1200

caaggtggct gccaaagccc agctccgagc tgcagctggg cttggtgctg gcatccctgg   1260

acttggagtt ggtgtcggcg tccctggact tggagttggt gctggtgttc ctggacttgg   1320

agttggtgct ggtgttcctg gcttcggggc agtacctgga gccctggctg ccgctaaagc   1380

agccaaatat ggagcagcag tgcctggggt ccttggaggg ctcggggctc tcggtggagt   1440

aggcatccca ggcggtgtgg tgggagccgg acccgccgcc gccgctgccg cagccaaagc   1500

tgctgccaaa gccgcccagt ttggcctagt gggagccgct gggctcggag gactcggagt   1560

cggagggctt ggagttccag gtgttggggg ccttggaggt atacctccag ctgcagccgc   1620

taaagcagct aaatacggag tggcagcaag acctggcttc ggattgtctc ccattttccc   1680

aggtggggcc tgcctgggga aagcttgtgg ccggaagaga aaatgagctt cctaggaccc   1740

ctgactcacg acctcatcaa cgttggtgct actgcttggt ggagaatgta aaccctttgt   1800

aaccccatcc catgcccctc cgactcccca ccccaggagg gaacgggcag gccgggcggc   1860

cttgcagatc cacagggcaa ggaaacaaga ggggagcggc caagtgcccc gaccaggagg   1920

ccccctactt cagaggcaag ggccatgtgg tcctggcccc ccaccccatc ccttcccacc   1980

taggagctcc ccctccacac agcctccatc tccaggggaa cttggtgcta cacgctggtg   2040

ctcttatctt cctgggggga gggaggaggg aagggtggcc cctcggggaa ccccctacct   2100

ggggctcctc taaagatggt gcagacactt cctgggcagt cccagctccc cctgcccacc   2160

aggacccacc gttggctgcc atccagttgg tacccaagca cctgaagcct caaagctgga   2220

ttcgctctag catccctcct ctcctgggtc cacttggccg tctcctcccc accgatcgct   2280

gttccccaca tctggggcgc ttttgggttg gaaaaccacc ccacactggg aatagccacc   2340

ttgcccttgt agaatccatc cgcccatccg tccattcatc catcggtccg tccatccatg   2400

tccccagttg accgcccggc accactagct ggctgggtgc acccaccatc aacctggttg   2460

acctgtcatg gccgcctgtg ccctgcctcc acccccatcc tacactcccc cagggcgtgc   2520

ggggctgtgc agactggggt gccaggcatc tcctccccac ccggggtgtc cccacatgca   2580

gtactgtata ccccccatcc ctccctcggt ccactgaact tcagagcagt tcccattcct   2640

gccccgccca tctttttgtg tctcgctgtg atagatcaat aaatatttta ttttttgtcc   2700

tggatatttg gggattattt ttgattgttg atattctctt ttggttttat tgttgtggtt   2760

cattgaaaaa aaaagataat ttttttttct gatccgggga gctgtatccc cagtagaaaa   2820

aacattttaa tcactctaat ataactctgg atgaaacaca cctttttttt taataagaaa   2880

agagaattaa ctgcttcaga aatgactaat aaatgaaaaa cctttaaagg aaa          2933


<210>  3869
<211>  570
<212>  PRT
<213>  Homo sapiens

<400>  3869

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Val Gly 
65                  70                  75                  80


Gly Ala Phe Ala Gly Ile Pro Gly Val Gly Pro Phe Gly Gly Pro Gln 
                85                  90                  95


Pro Gly Val Pro Leu Gly Tyr Pro Ile Lys Ala Pro Lys Leu Pro Gly 
            100                 105                 110


Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala Gly Lys Ala Gly Tyr Pro 
        115                 120                 125


Thr Gly Thr Gly Val Gly Pro Gln Ala Ala Ala Ala Ala Ala Ala Lys 
    130                 135                 140


Ala Ala Ala Lys Phe Gly Ala Gly Ala Ala Gly Val Leu Pro Gly Val 
145                 150                 155                 160


Gly Gly Ala Gly Val Pro Gly Val Pro Gly Ala Ile Pro Gly Ile Gly 
                165                 170                 175


Gly Ile Ala Gly Val Gly Thr Pro Ala Ala Ala Ala Ala Ala Ala Ala 
            180                 185                 190


Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Ala Gly Leu Val Pro Gly 
        195                 200                 205


Gly Pro Gly Phe Gly Pro Gly Val Val Gly Val Pro Gly Ala Gly Val 
    210                 215                 220


Pro Gly Val Gly Val Pro Gly Ala Gly Ile Pro Val Val Pro Gly Ala 
225                 230                 235                 240


Gly Ile Pro Gly Ala Ala Val Pro Gly Val Val Ser Pro Glu Ala Ala 
                245                 250                 255


Ala Lys Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Arg Pro Gly Val 
            260                 265                 270


Gly Val Gly Gly Ile Pro Thr Tyr Gly Val Gly Ala Gly Gly Phe Pro 
        275                 280                 285


Gly Phe Gly Val Gly Val Gly Gly Ile Pro Gly Val Ala Gly Val Pro 
    290                 295                 300


Gly Val Gly Gly Val Pro Gly Val Gly Gly Val Pro Gly Val Gly Ile 
305                 310                 315                 320


Ser Pro Glu Ala Gln Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly 
                325                 330                 335


Leu Val Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly 
            340                 345                 350


Val Gly Val Ala Pro Gly Val Gly Leu Ala Pro Gly Val Gly Val Ala 
        355                 360                 365


Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Ile Gly 
    370                 375                 380


Pro Gly Gly Val Ala Ala Ala Ala Lys Ser Ala Ala Lys Val Ala Ala 
385                 390                 395                 400


Lys Ala Gln Leu Arg Ala Ala Ala Gly Leu Gly Ala Gly Ile Pro Gly 
                405                 410                 415


Leu Gly Val Gly Val Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val 
            420                 425                 430


Pro Gly Leu Gly Val Gly Ala Gly Val Pro Gly Phe Gly Ala Val Pro 
        435                 440                 445


Gly Ala Leu Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Val Pro 
    450                 455                 460


Gly Val Leu Gly Gly Leu Gly Ala Leu Gly Gly Val Gly Ile Pro Gly 
465                 470                 475                 480


Gly Val Val Gly Ala Gly Pro Ala Ala Ala Ala Ala Ala Ala Lys Ala 
                485                 490                 495


Ala Ala Lys Ala Ala Gln Phe Gly Leu Val Gly Ala Ala Gly Leu Gly 
            500                 505                 510


Gly Leu Gly Val Gly Gly Leu Gly Val Pro Gly Val Gly Gly Leu Gly 
        515                 520                 525


Gly Ile Pro Pro Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Val Ala 
    530                 535                 540


Ala Arg Pro Gly Phe Gly Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys 
545                 550                 555                 560


Leu Gly Lys Ala Cys Gly Arg Lys Arg Lys 
                565                 570


<210>  3870
<211>  467
<212>  DNA
<213>  Homo sapiens

<400>  3870
ctccccgaga tggcgggtct gacggcggcg gccccgcggc ccggagtcct cctgctcctg     60

ctgtccatcc tccacccctc tcggcctgga ggggtccctg gggccattcc tggtggagtt    120

cctggaggag tcttttatcc aggggctggt ctcggagccc ttggaggagg agcgctgggg    180

cctggaggca aacctcttaa gccagggctc ggcgccttcc ccgcagttac ctttccgggg    240

gctctggtgc ctggtggagt ggctgacgct gctgcagcct ataaagctgc taaggctggc    300

gctgggcttg gtggtgtccc aggagttggt ggcttaggag tgtctgcagg tgcggtggtt    360

cctcagcctg gagccggagt gaagcctggg aaagtgccgg gtcagtgcgg aatccctggg    420

gctggaggac agagggcagg gaggggcaga gggcagggag gaacaga                  467


<210>  3871
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  3871

Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60


Pro Gly Leu Gly Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val 
65                  70                  75                  80


Pro Gly Gly Val Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala 
                85                  90                  95


Gly Ala Gly Leu Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser 
            100                 105                 110


Ala Gly Ala Val Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys 
        115                 120                 125


Val Pro Gly Gln Cys Gly Ile Pro Gly Ala Gly Gly Gln Arg Ala Gly 
    130                 135                 140


Arg Gly Arg Gly Gln Gly Gly 
145                 150


<210>  3872
<211>  520
<212>  DNA
<213>  Homo sapiens

<400>  3872
gacactacag aaggtaggaa cattgacacg cctaccagaa gtcacaccca cttaaaaatg     60

caattaacaa gacattgatt tacagctatt aagagcatac aggctggaca tggtggctta    120

tgcctgtaat ctcaacactc tgggaggcag agaaacaagg attgcttgag gccaggagtt    180

tcagaccagc ctggacaaca tagggctggt ctcggagccc ttggaggagg agcgctgggg    240

cctggaggca aacctcttaa gccagttccc ggagggcttg cgggtgctgg ccttggggca    300

gggctcggcg ccttccccgc agttaccttt ccgggggctc tggtgcctgg tggagtggct    360

gacgctgctg cagcctataa agctgctaag gctggcgctg ggcttggtgg tgtcccagga    420

gttggtggct taggagtgtc tgcaggtgcg gtggttcctc agcctggagc cggagtgaag    480

cctgggaaag tgccgggtca gtgcggaatc cctggggctg                          520


<210>  3873
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  3873

Ser Gln His Ser Gly Arg Gln Arg Asn Lys Asp Cys Leu Arg Pro Gly 
1               5                   10                  15


Val Ser Asp Gln Pro Gly Gln His Arg Ala Gly Leu Gly Ala Leu Gly 
            20                  25                  30


Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys Pro Val Pro Gly 
        35                  40                  45


Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly Ala Phe Pro Ala 
    50                  55                  60


Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val Ala Asp Ala Ala 
65                  70                  75                  80


Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu Gly Gly Val Pro 
                85                  90                  95


Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val Val Pro Gln Pro 
            100                 105                 110


Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly Gln Cys Gly Ile Pro 
        115                 120                 125


Gly 



<210>  3874
<211>  894
<212>  DNA
<213>  Homo sapiens

<400>  3874
aagaaagaaa gaaaagaggg ccagatgcag tggctcatgc ctgtaatccc agcactttgg     60

gaggccgagg tgggcggatc acctgaggtc agcctgacca acacggtgaa gccctgtctc    120

tactaataat acaaaaatta gctgggcgtg gtggcctgca cctgtaatcc cagctacttg    180

ggaggctgag gcgggagaat cgccagaacc tgggaggcag aggttgcggt gagttgagat    240

caccccattc caccccagcc tgggcgacaa gagcgaaact ccatctccga aaaaagaaac    300

cccagagttc atgtgagcgc agcatgcgat gactggtctg ggaagaactg gccattcctt    360

gggcctcctg gccccttggt gctgtctggc ccagtgtcca cagttccagg gctgtagtga    420

cagcttttta tcattacagg tgtaggtgga gcttttgctg gaatcccagg agttggaccc    480

tttgggggac cgcaacctgg agtcccactg gggtatccca tcaaggcccc caagctgcct    540

ggtggctatg gactgcccta caccacaggg aaactgccct atggctatgg gcccggagga    600

gtggctggtg cagcgggcaa ggctggttac ccaacaggga caggggttgg cccccaggca    660

gcagcagcag cggcagctaa agcagcagca aagttcggtg ctggagcagc cggagtcctc    720

cctggtgttg gaggggctgg tgttcctggc gtgcctgggg caattcctgg aattggaggc    780

atcgcaggcg ttgggactcc agctgcagct gcagctgcag cagcagccgc taaggcagcc    840

aagtatggag ctgctgcagg cttagtgcct ggtgggccag gctttggccc ggga          894


<210>  3875
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  3875

Met Asp Cys Pro Thr Pro Gln Gly Asn Cys Pro Met Ala Met Gly Pro 
1               5                   10                  15


Glu Glu Trp Leu Val Gln Arg Ala Arg Leu Val Thr Gln Gln Gly Gln 
            20                  25                  30


Gly Leu Ala Pro Arg Gln Gln Gln Gln Arg Gln Leu Lys Gln Gln Gln 
        35                  40                  45


Ser Ser Val Leu Glu Gln Pro Glu Ser Ser Leu Val Leu Glu Gly Leu 
    50                  55                  60


Val Phe Leu Ala Cys Leu Gly Gln Phe Leu Glu Leu Glu Ala Ser Gln 
65                  70                  75                  80


Ala Leu Gly Leu Gln Leu Gln Leu Gln Leu Gln Gln Gln Pro Leu Arg 
                85                  90                  95


Gln Pro Ser Met Glu Leu Leu Gln Ala 
            100                 105


<210>  3876
<211>  748
<212>  DNA
<213>  Homo sapiens

<400>  3876
gtgctgggac ctgaacttgc tctctttatt cccacaggag ttggaccctt tgggggaccg     60

caacctggag tcccactggg gtatcccatc aaggccccca agctgcctgg tggctatgga    120

ctgccctaca ccacagggaa actgccctat ggctatgggc ccggaggagt ggctggtgca    180

gcgggcaagg ctggttaccc aacagggaca ggggttggcc cccaggcagc agcagcagcg    240

gcagctaaag cagcagcaaa gttcggtgct ggagcagccg gagtcctccc tggtgttgga    300

ggggctggtg ttcctggcgt gcctggggca attcctggaa ttggaggcat cgcaggtaac    360

atctgtccca gcagggggcg ggtgtgtcct tgagatggcc acagggcaag gacctcaccc    420

tctgtggctg tgttttcagg cgttgggact ccagctgcag ctgcagctgc agcagcagcc    480

gctaaggcag ccaagtatgg tgagtgcctc ccggggtggc aagtccacgg ctcgggcccc    540

tgcatagacc tcggagaccc tagccgcaaa gccagatgga cttggccttt gttccttccc    600

aaatatgcat tgttcatgcc tccttacctt tgccccttct gatcactcta cctgagatgc    660

catctctatt gttttgccct gattaactca gcagagggag gggaccctgc agaggggaca    720

tggctcctcc cactccatcc cctccagg                                       748


<210>  3877
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  3877

Met Asp Cys Pro Thr Pro Gln Gly Asn Cys Pro Met Ala Met Gly Pro 
1               5                   10                  15


Glu Glu Trp Leu Val Gln Arg Ala Arg Leu Val Thr Gln Gln Gly Gln 
            20                  25                  30


Gly Leu Ala Pro Arg Gln Gln Gln Gln Arg Gln Leu Lys Gln Gln Gln 
        35                  40                  45


Ser Ser Val Leu Glu Gln Pro Glu Ser Ser Leu Val Leu Glu Gly Leu 
    50                  55                  60


Val Phe Leu Ala Cys Leu Gly Gln Phe Leu Glu Leu Glu Ala Ser Gln 
65                  70                  75                  80


Val Thr Ser Val Pro Ala Gly Gly Gly Cys Val Leu Glu Met Ala Thr 
                85                  90                  95


Gly Gln Gly Pro His Pro Leu Trp Leu Cys Phe Gln Ala Leu Gly Leu 
            100                 105                 110


Gln Leu Gln Leu Gln Leu Gln Gln Gln Pro Leu Arg Gln Pro Ser Met 
        115                 120                 125


Val Ser Ala Ser Arg Gly Gly Lys Ser Thr Ala Arg Ala Pro Ala 
    130                 135                 140


<210>  3878
<211>  590
<212>  DNA
<213>  Homo sapiens

<400>  3878
gagggagaga gaaagaaaga aagagagaga gagagagaga aagaaagaaa gaaagagaaa     60

ggaaggaaag aaaagaaaag aaaaagaaag agatcacatt cctccagctc actgattcaa    120

atcctagagc tctttaggga ccctcttagt ctctccacat ctctctgatg agtaggatcc    180

atgcagagga aatgtcaacc cacctgcaat cctgcattca ggaccaactg tcacttccat    240

actctactaa ccacccttct agcccctctg aggttcccat aggttagggg aacaatgctt    300

tttcttccac aggagctgct gcaggcttag tgcctggtgg gccaggcttt ggcccgggag    360

tagttggtgt cccaggagct ggcgttccag gtgttggtgt cccaggagct gggattccag    420

ttgtcccagg tgctgggatc ccaggtgctg cggttccagg ggttgtgtca ccagaagcag    480

ctgctaaggc agctgcaaag gcagccaaat acggggccag gcccggagtc ggagttggag    540

gcattcctac ttacggggtt ggagctgggg gctttcccgg ctttggtgtc               590


<210>  3879
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  3879

Met Ser Arg Ile His Ala Glu Glu Met Ser Thr His Leu Gln Ser Cys 
1               5                   10                  15


Ile Gln Asp Gln Leu Ser Leu Pro Tyr Ser Thr Asn His Pro Ser Ser 
            20                  25                  30


Pro Ser Glu Val Pro Ile Gly 
        35


<210>  3880
<211>  501
<212>  DNA
<213>  Homo sapiens

<400>  3880
tttaaacacg gctcggagga gacccaggca cggcttctga gggtctcttt ctttctcgtt     60

tccttgtagc cgaagctcag gcagcagctg ccgccaaggc tgccaagtac ggagtgggga    120

ccccagcagc tgcagctgct aaagcagccg ccaaagccgc ccagtttggg ttagttcctg    180

gtgtcggcgt ggctcctgga gttggcgtgg ctcctggtgt cggtgtggct cctggagttg    240

gcttggctcc tggagttggc gtggctcctg gagttggtgt ggctcctggc gttggcgtgg    300

ctcccggcat tggccctggt ggagttgcag ctgcagcaaa atccgctgcc aaggtggctg    360

ccaaagccca gctccgagct gcagctgggc ttggtgctgg catccctgga cttggagttg    420

gtgtcggcgt ccctggactt ggagttggtg ctggtgttcc tggacttgga gttggtgctg    480

gtgttcctgg cttcggggca g                                              501


<210>  3881
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  3881

Thr Arg Leu Gly Gly Asp Pro Gly Thr Ala Ser Glu Gly Leu Phe Leu 
1               5                   10                  15


Ser Arg Phe Leu Val Ala Glu Ala Gln Ala Ala Ala Ala Ala Lys Ala 
            20                  25                  30


Ala Lys Tyr Gly Val Gly Thr Pro Ala Ala Ala Ala Ala Lys Ala Ala 
        35                  40                  45


Ala Lys Ala Ala Gln Phe Gly Leu Val Pro Gly Val Gly Val Ala Pro 
    50                  55                  60


Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Leu 
65                  70                  75                  80


Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val 
                85                  90                  95


Gly Val Ala Pro Gly Ile Gly Pro Gly Gly Val Ala Ala Ala Ala Lys 
            100                 105                 110


Ser Ala Ala Lys Val Ala Ala Lys Ala Gln Leu Arg Ala Ala Ala Gly 
        115                 120                 125


Leu Gly Ala Gly Ile Pro Gly Leu Gly Val Gly Val Gly Val Pro Gly 
    130                 135                 140


Leu Gly Val Gly Ala Gly Val Pro Gly Leu Gly Val Gly Ala Gly Val 
145                 150                 155                 160


Pro Gly Phe Gly 



<210>  3882
<211>  532
<212>  DNA
<213>  Homo sapiens

<400>  3882
aagcagtcag cagtgagcag gggaggaggc cagggctgct gggggtcggc gctgaggaag     60

ccaggatttt ccgagggcca atgccgggag ccacgccaac gccaggagcc acaccaactc    120

caggagccac gccaactcca ggagccaagc caactccagg agccacaccg acaccaggag    180

ccacgccaac tccaggagcc acgccgacac caggaactaa ccctgcaaga ttgagaagag    240

ctgatcatta accaagacct gatcaaagag gacagaagct tatggaaaga gggctggagc    300

ctcggccctg gcatagattt gctgtgtgac cctggatcag ttactttccc ttgctgggcc    360

tcagcttcct cctccctaat atgaagtgtg tgcaggctca ggagttcata actttgtttt    420

tttggagaca gagtctcact ctatcgccca ggctggagtg caatggcgtg atctcgactc    480

actgcaacca ccacctcccg agttcaagtg agtctcctgc ctcagcctcc tg            532


<210>  3883
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  3883

Met Pro Gly Ala Thr Pro Thr Pro Gly Ala Thr Pro Thr Pro Gly Ala 
1               5                   10                  15


Thr Pro Thr Pro Gly Ala Lys Pro Thr Pro Gly Ala Thr Pro Thr Pro 
            20                  25                  30


Gly Ala Thr Pro Thr Pro Gly Ala Thr Pro Thr Pro Gly Thr Asn Pro 
        35                  40                  45


Ala Arg Leu Arg Arg Ala Asp His 
    50                  55


<210>  3884
<211>  438
<212>  DNA
<213>  Homo sapiens

<400>  3884
ggaggccagg gctgctgggg gtcggcgctg aggaagccag gattttccga gccaagccaa     60

ctccaggagc cacaccgaca ccaggagcca cgccaactcc aggagccacg ccgacaccag    120

gaactaaccc tgcaagattg agaagagctg atcattaacc aagacctgat caaagaggac    180

agaagcttat ggaaagaggg ctggagcctc ggccctggca tagatttgct gtgtgaccct    240

ggatcagtta ctttcccttg ctgggcctca gcttcctcct ccctaatatg aagtgtgtgc    300

aggctcagga gttcataact ttgttttttt ggagacagag tctcactcta tcgcccaggc    360

tggagtgcaa tggcgtgatc tcgactcact gcaaccacca cctcccgagt tcaagtgagt    420

ctcctgcctc agcctcct                                                  438


<210>  3885
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  3885

Met Lys Cys Val Gln Ala Gln Glu Phe Ile Thr Leu Phe Phe Trp Arg 
1               5                   10                  15


Gln Ser Leu Thr Leu Ser Pro Arg Leu Glu Cys Asn Gly Val Ile Ser 
            20                  25                  30


Thr His Cys Asn His His Leu Pro Ser Ser Ser Glu Ser Pro Ala Ser 
        35                  40                  45


Ala 



<210>  3886
<211>  1379
<212>  DNA
<213>  Homo sapiens

<400>  3886
ggtgctggtg ttcctggctt cggggcagta cctggagccc tggctgccgc taaagcagcc     60

aaatatggag cagcagtgcc tggggtcctt ggagggctcg gggctctcgg tggagtaggc    120

atcccaggcg gtgtggtggg agccggaccc gccgccgccg ctgccgcagc caaagctgct    180

gccaaagccg cccagtttgg cctagtggga gccgctgggc tcggaggact cggagtcgga    240

gggcttggag ttccaggtgt tgggggcctt ggaggtatac ctccagctgc agccgctaaa    300

gcagctaaat acggagtggc agcaagacct ggcttcggat tgtctcccat tttcccaggt    360

ggggcctgcc tggggaaagc ttgtggccgg aagagaaaat gagcttccta ggacccctga    420

ctcacgacct catcaacgtt ggtgctactg cttggtggag aatgtaaacc ctttgtaacc    480

ccatcccatg cccctccgac tccccacccc aggagggaac gggcaggccg ggcggccttg    540

cagatccaca gggcaaggaa acaagagggg agcggccaag tgccccgacc aggaggcccc    600

ctacttcaga ggcaagggcc atgtggtcct ggccccccac cccatccctt cccacctagg    660

agctccccct ccacacagcc tccatctcca ggggaacttg gtgctacacg ctggtgctct    720

tatcttcctg gggggaggga ggagggaagg gtggcccctc ggggaacccc ctacctgggg    780

ctcctctaaa gatggtgcag acacttcctg ggcagtccca gctccccctg cccaccagga    840

cccaccgttg gctgccatcc agttggtacc caagcacctg aagcctcaaa gctggattcg    900

ctctagcatc cctcctctcc tgggtccact tggccgtctc ctccccaccg atcgctgttc    960

cccacatctg gggcgctttt gggttggaaa accaccccac actgggaata gccaccttgc   1020

ccttgtagaa tccatccgcc catccgtcca ttcatccatc ggtccgtcca tccatgtccc   1080

cagttgaccg cccggcacca ctagctggct gggtgcaccc accatcaacc tggttgacct   1140

gtcatggccg cctgtgccct gcctccaccc ccatcctaca ctcccccagg gcgtgcgggg   1200

ctgtgcagac tggggtgcca ggcatctcct ccccacccgg ggtgtcccca catgcagtac   1260

tgtatacccc ccatccctcc ctcggtccac tgaacttcag agcagttccc attcctgccc   1320

cgcccatctt tttgtgtctc gctgtgatag atcaataaat attttatttt ttgtcctgg    1379


<210>  3887
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  3887

Met Pro Leu Arg Leu Pro Thr Pro Gly Gly Asn Gly Gln Ala Gly Arg 
1               5                   10                  15


Pro Cys Arg Ser Thr Gly Gln Gly Asn Lys Arg Gly Ala Ala Lys Cys 
            20                  25                  30


Pro Asp Gln Glu Ala Pro Tyr Phe Arg Gly Lys Gly His Val Val Leu 
        35                  40                  45


Ala Pro His Pro Ile Pro Ser His Leu Gly Ala Pro Pro Pro His Ser 
    50                  55                  60


Leu His Leu Gln Gly Asn Leu Val Leu His Ala Gly Ala Leu Ile Phe 
65                  70                  75                  80


Leu Gly Gly Gly Arg Arg Glu Gly Trp Pro Leu Gly Glu Pro Pro Thr 
                85                  90                  95


Trp Gly Ser Ser Lys Asp Gly Ala Asp Thr Ser Trp Ala Val Pro Ala 
            100                 105                 110


Pro Pro Ala His Gln Asp Pro Pro Leu Ala Ala Ile Gln Leu Val Pro 
        115                 120                 125


Lys His Leu Lys Pro Gln Ser Trp Ile Arg Ser Ser Ile Pro Pro Leu 
    130                 135                 140


Leu Gly Pro Leu Gly Arg Leu Leu Pro Thr Asp Arg Cys Ser Pro His 
145                 150                 155                 160


Leu Gly Arg Phe Trp Val Gly Lys Pro Pro His Thr Gly Asn Ser His 
                165                 170                 175


Leu Ala Leu Val Glu Ser Ile Arg Pro Ser Val His Ser Ser Ile Gly 
            180                 185                 190


Pro Ser Ile His Val Pro Ser 
        195


<210>  3888
<211>  1609
<212>  DNA
<213>  Homo sapiens

<400>  3888
ggtgctggtg ttcctggctt cggggcagta cctggagccc tggctgccgc taaagcagcc     60

aaatatggag cagcagtgcc tggggtcctt ggagggctcg gggctctcgg tggagtaggc    120

atcccaggcg gtgtggtggg agccggaccc gccgccgccg ctgccgcagc caaagctgct    180

gccaaagccg cccagtttgg cctagtggga gccgctgggc tcggaggact cggagtcgga    240

gggcttggag ttccaggtgt tgggggcctt ggaggtatac ctccagctgc agccgctaaa    300

gcagctaaat acggagtggc agcaagacct ggcttcggat tgtctcccat tttcccaggt    360

ggggcctgcc tggggaaagc ttgtggccgg aagagaaaat gagcttccta ggacccctga    420

ctcacgacct catcaacgtt ggtgctactg cttggtggag aatgtaaacc ctttgtaacc    480

ccatcccatg cccctccgac tccccacccc aggagggaac gggcaggccg ggcggccttg    540

cagatccaca gggcaaggaa acaagagggg agcggccaag tgccccgacc aggaggcccc    600

ctacttcaga ggcaagggcc atgtggtcct ggccccccac cccatccctt cccacctagg    660

agctccccct ccacacagcc tccatctcca ggggaacttg gtgctacacg ctggtgctct    720

tatcttcctg gggggaggga ggagggaagg gtggcccctc ggggaacccc ctacctgggg    780

ctcctctaaa gatggtgcag acacttcctg ggcagtccca gctccccctg cccaccagga    840

cccaccgttg gctgccatcc agttggtacc caagcacctg aagcctcaaa gctggattcg    900

ctctagcatc cctcctctcc tgggtccact tggccgtctc ctccccaccg atcgctgttc    960

cccacatctg gggcgctttt gggttggaaa accaccccac actgggaata gccaccttgc   1020

ccttgtagaa tccatccgcc catccgtcca ttcatccatc ggtccgtcca tccatgtccc   1080

cagttgaccg cccggcacca ctagctggct gggtgcaccc accatcaacc tggttgacct   1140

gtcatggccg cctgtgccct gcctccaccc ccatcctaca ctcccccagg gcgtgcgggg   1200

ctgtgcagac tggggtgcca ggcatctcct ccccacccgg ggtgtcccca catgcagtac   1260

tgtatacccc ccatccctcc ctcggtccac tgaacttcag agcagttccc attcctgccc   1320

cgcccatctt tttgtgtctc gctgtgatag atcaataaat attttatttt ttgtcctgga   1380

tatttgggga ttatttttga ttgttgatat tctcttttgg ttttattgtt gtggttcatt   1440

gaaaaaaaaa gataattttt ttttctgatc cggggagctg tatccccagt agaaaaaaca   1500

ttttaatcac tctaatataa ctctggatga aacacacctt tttttttaat aagaaaagag   1560

aattaactgc ttcagaaatg actaataaat gaaaaacctt taaaggaaa               1609


<210>  3889
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  3889

Met Pro Leu Arg Leu Pro Thr Pro Gly Gly Asn Gly Gln Ala Gly Arg 
1               5                   10                  15


Pro Cys Arg Ser Thr Gly Gln Gly Asn Lys Arg Gly Ala Ala Lys Cys 
            20                  25                  30


Pro Asp Gln Glu Ala Pro Tyr Phe Arg Gly Lys Gly His Val Val Leu 
        35                  40                  45


Ala Pro His Pro Ile Pro Ser His Leu Gly Ala Pro Pro Pro His Ser 
    50                  55                  60


Leu His Leu Gln Gly Asn Leu Val Leu His Ala Gly Ala Leu Ile Phe 
65                  70                  75                  80


Leu Gly Gly Gly Arg Arg Glu Gly Trp Pro Leu Gly Glu Pro Pro Thr 
                85                  90                  95


Trp Gly Ser Ser Lys Asp Gly Ala Asp Thr Ser Trp Ala Val Pro Ala 
            100                 105                 110


Pro Pro Ala His Gln Asp Pro Pro Leu Ala Ala Ile Gln Leu Val Pro 
        115                 120                 125


Lys His Leu Lys Pro Gln Ser Trp Ile Arg Ser Ser Ile Pro Pro Leu 
    130                 135                 140


Leu Gly Pro Leu Gly Arg Leu Leu Pro Thr Asp Arg Cys Ser Pro His 
145                 150                 155                 160


Leu Gly Arg Phe Trp Val Gly Lys Pro Pro His Thr Gly Asn Ser His 
                165                 170                 175


Leu Ala Leu Val Glu Ser Ile Arg Pro Ser Val His Ser Ser Ile Gly 
            180                 185                 190


Pro Ser Ile His Val Pro Ser 
        195


<210>  3890
<211>  604
<212>  DNA
<213>  Homo sapiens

<400>  3890
ggagtggcag caagacctgg cttcggattg tctcccattt tcccagctcc ccctgcccac     60

caggacccac cgttggctgc catccagttg gtacccaagc acctgaagcc tcaaagctgg    120

attcgctcta gcatccctcc tctcctgggt ccacttggcc gtctcctccc caccgatcgc    180

tgttccccac atctggggcg cttttgggtt ggaaaaccac cccacactgg gaatagccac    240

cttgcccttg tagaatccat ccgcccatcc gtccattcat ccatcggtcc gtccatccat    300

gtccccagtt gaccgcccgg caccactagc tggctgggtg cacccaccat caacctggtt    360

gacctgtcat ggccgcctgt gccctgcctc cacccccatc ctacactccc ccagggcgtg    420

cggggctgtg cagactgggg tgccaggcat ctcctcccca cccggggtgt ccccacatgc    480

agtactgtat accccccatc cctccctcgg tccactgaac ttcagagcag ttcccattcc    540

tgccccgccc atctttttgt gtctcgctgt gatagatcaa taaatatttt attttttgtc    600

ctgg                                                                 604


<210>  3891
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  3891

Met Ser Pro Val Asp Arg Pro Ala Pro Leu Ala Gly Trp Val His Pro 
1               5                   10                  15


Pro Ser Thr Trp Leu Thr Cys His Gly Arg Leu Cys Pro Ala Ser Thr 
            20                  25                  30


Pro Ile Leu His Ser Pro Arg Ala Cys Gly Ala Val Gln Thr Gly Val 
        35                  40                  45


Pro Gly Ile Ser Ser Pro Pro Gly Val Ser Pro His Ala Val Leu Tyr 
    50                  55                  60


Thr Pro His Pro Ser Leu Gly Pro Leu Asn Phe Arg Ala Val Pro Ile 
65                  70                  75                  80


Pro Ala Pro Pro Ile Phe Leu Cys Leu Ala Val Ile Asp Gln 
                85                  90


<210>  3892
<211>  834
<212>  DNA
<213>  Homo sapiens

<400>  3892
ggagtggcag caagacctgg cttcggattg tctcccattt tcccagctcc ccctgcccac     60

caggacccac cgttggctgc catccagttg gtacccaagc acctgaagcc tcaaagctgg    120

attcgctcta gcatccctcc tctcctgggt ccacttggcc gtctcctccc caccgatcgc    180

tgttccccac atctggggcg cttttgggtt ggaaaaccac cccacactgg gaatagccac    240

cttgcccttg tagaatccat ccgcccatcc gtccattcat ccatcggtcc gtccatccat    300

gtccccagtt gaccgcccgg caccactagc tggctgggtg cacccaccat caacctggtt    360

gacctgtcat ggccgcctgt gccctgcctc cacccccatc ctacactccc ccagggcgtg    420

cggggctgtg cagactgggg tgccaggcat ctcctcccca cccggggtgt ccccacatgc    480

agtactgtat accccccatc cctccctcgg tccactgaac ttcagagcag ttcccattcc    540

tgccccgccc atctttttgt gtctcgctgt gatagatcaa taaatatttt attttttgtc    600

ctggatattt ggggattatt tttgattgtt gatattctct tttggtttta ttgttgtggt    660

tcattgaaaa aaaaagataa tttttttttc tgatccgggg agctgtatcc ccagtagaaa    720

aaacatttta atcactctaa tataactctg gatgaaacac accttttttt ttaataagaa    780

aagagaatta actgcttcag aaatgactaa taaatgaaaa acctttaaag gaaa          834


<210>  3893
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  3893

Met Ser Pro Val Asp Arg Pro Ala Pro Leu Ala Gly Trp Val His Pro 
1               5                   10                  15


Pro Ser Thr Trp Leu Thr Cys His Gly Arg Leu Cys Pro Ala Ser Thr 
            20                  25                  30


Pro Ile Leu His Ser Pro Arg Ala Cys Gly Ala Val Gln Thr Gly Val 
        35                  40                  45


Pro Gly Ile Ser Ser Pro Pro Gly Val Ser Pro His Ala Val Leu Tyr 
    50                  55                  60


Thr Pro His Pro Ser Leu Gly Pro Leu Asn Phe Arg Ala Val Pro Ile 
65                  70                  75                  80


Pro Ala Pro Pro Ile Phe Leu Cys Leu Ala Val Ile Asp Gln 
                85                  90


<210>  3894
<211>  831
<212>  DNA
<213>  Homo sapiens

<400>  3894
tccaggtggg gcctgcctgg ggaaagcttg tggccggaag agaaaatgag cttcctagga     60

cccctgactc acgacctcat caacgttggt gctactgctt ggtggagaat gtaaaccctt    120

tgtaacccca tcccatgccc ctccgactcc ccaccccagg agggaacggg caggccgggc    180

ggccttgcag atccacaggg caaggaaaca agaggggagc ggactgggaa tagccacctt    240

gcccttgtag aatccatccg cccatccgtc cattcatcca tcggtccgtc catccatgtc    300

cccagttgac cgcccggcac cactagctgg ctgggtgcac ccaccatcaa cctggttgac    360

ctgtcatggc cgcctgtgcc ctgcctccac ccccatccta cactccccca gggcgtgcgg    420

ggctgtgcag actggggtgc caggcatctc ctccccaccc ggggtgtccc cacatgcagt    480

actgtatacc ccccatccct ccctcggtcc actgaacttc agagcagttc ccattcctgc    540

cccgcccatc tttttgtgtc tcgctgtgat agatcaataa atattttatt ttttgtcctg    600

gatatttggg gattattttt gattgttgat attctctttt ggttttattg ttgtggttca    660

ttgaaaaaaa aagataattt ttttttctga tccggggagc tgtatcccca gtagaaaaaa    720

cattttaatc actctaatat aactctggat gaaacacacc ttttttttta ataagaaaag    780

agaattaact gcttcagaaa tgactaataa atgaaaaacc tttaaaggaa a             831


<210>  3895
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  3895

Met Pro Leu Arg Leu Pro Thr Pro Gly Gly Asn Gly Gln Ala Gly Arg 
1               5                   10                  15


Pro Cys Arg Ser Thr Gly Gln Gly Asn Lys Arg Gly Ala Asp Trp Glu 
            20                  25                  30


<210>  3896
<211>  3311
<212>  DNA
<213>  Homo sapiens

<400>  3896
acaggccccg cctcggtccg cccctccgct cgctccccaa gccgccgcgg cgccgagccg     60

gtttccccgc cggtgtccga gaggcgcccc cggcccggcc gcccccagcc ccagccccgc    120

cgggccccgc cccccgtcga gtgcatgagg ttgacgctac tttgttgcac ctggagggaa    180

gaacgtatgg gagaggaagg aagcgagttg cccgtgtgtg caagctgcgg ccagaggatc    240

tatgatggcc agtacctcca ggccctgaac gcggactggc acgcagactg cttcaggtgt    300

tgtgactgca gtgcctccct gtcgcaccag tactatgaga aggatgggca gctcttctgc    360

aagaaggact actgggcccg ctatggcgag tcctgccatg ggtgctctga gcaaatcacc    420

aagggactgg ttatggtggc tggggagctg aagtaccacc ccgagtgttt catctgcctc    480

acgtgtggga cctttatcgg tgacggggac acctacacgc tggtggagca ctccaagctg    540

tactgcgggc actgctacta ccagactgtg gtgacccccg tcatcgagca gatcctgcct    600

gactcccctg gctcccacct gccccacacc gtcaccctgg tgtccatccc agcctcatct    660

catggcaagc gtggactttc agtctccatt gaccccccgc acggcccacc gggctgtggc    720

accgagcact cacacaccgt ccgcgtccag ggagtggatc cgggctgcat gagcccagat    780

gtgaagaatt ccatccacgt cggagaccgg atcttggaaa tcaatggcac gcccatccga    840

aatgtgcccc tggacgagat tgacctgctg attcaggaaa ccagccgcct gctccagctg    900

accctcgagc atgaccctca cgatacactg ggccacgggc tggggcctga gaccagcccc    960

ctgagctctc cggcttatac tcccagcggg gaggcgggca gctctgcccg gcagaaacct   1020

gtcttgagga gctgcagcat cgacaggtct ccgggcgctg gctcactggg ctccccggcc   1080

tcccagcgca aggacctggg tcgctctgag tccctccgcg tagtctgccg gccacaccgc   1140

atcttccggc cgtcggacct catccacggg gaggtgctgg gcaagggctg cttcggccag   1200

gctatcaagg tgacacaccg tgagacaggt gaggtgatgg tgatgaagga gctgatccgg   1260

ttcgacgagg agacccagag gacgttcctc aaggaggtga aggtcatgcg atgcctggaa   1320

caccccaacg tgctcaagtt catcggggtg ctctacaagg acaagaggct caacttcatc   1380

actgagtaca tcaagggcgg cacgctccgg ggcatcatca agagcatgga cagccagtac   1440

ccatggagcc agagagtgag ctttgccaag gacatcgcat cagggatggc ctacctccac   1500

tccatgaaca tcatccaccg agacctcaac tcccacaact gcctggtccg cgagaacaag   1560

aatgtggtgg tggctgactt cgggctggcg cgtctcatgg tggacgagaa gactcagcct   1620

gagggcctgc ggagcctcaa gaagccagac cgcaagaagc gctacaccgt ggtgggcaac   1680

ccctactgga tggcacctga gatgatcaac ggccgcagct atgatgagaa ggtggatgtg   1740

ttctcctttg ggatcgtcct gtgcgagatc atcgggcggg tgaacgcaga ccctgactac   1800

ctgccccgca ccatggactt tggcctcaac gtgcgaggat tcctggaccg ctactgcccc   1860

ccaaactgcc ccccgagctt cttccccatc accgtgcgct gttgcgatct ggaccccgag   1920

aagaggccat cctttgtgaa gctggaacac tggctggaga ccctccgcat gcacctggcc   1980

ggccacctgc cactgggccc acagctggag cagctggaca gaggtttctg ggagacctac   2040

cggcgcggcg agagcggact gcctgcccac cctgaggtcc ccgactgagc cagggccact   2100

cagctgcccc tgtccccacc tctggagaat ccacccccac cagattcctc cgcgggaggt   2160

ggccctcagc tgggacagtg gggacccagg cttctcctca gagccaggcc ctgacttgcc   2220

ttctcccacc ccgtggaccg cttcccctgc cttctctctg ccgtggccca gagccggccc   2280

agctgcacac acacaccatg ctctcgccct gctgtaacct ctgtcttggc agggctgtcc   2340

cctcttgctt ctccttgcat gagctggagg gcctgtgtga gttacgcccc tttccacacg   2400

ccgctgcccc agcaaccctg ttcacgctcc acctgtctgg tccatagctc cctggaggct   2460

gggccaggag gcagcctccg aaccatgccc catataacgc ttgggtgcgt gggagggcgc   2520

acatcagggc agaggccaag ttccaggtgt ctgtgttccc aggaaccaaa tggggagtct   2580

ggggcccgtt ttccccccag ggggtgtcta ggtagcaaca ggtatcgagg actctccaaa   2640

cccccaaagc agagagaggg ctgatcccat ggggcggagg tccccagtgg ctgagcaaac   2700

agccccttct ctcgctttgg gtcttttttt tgtttctttc ttaaagccac tttagtgaga   2760

agcaggtacc aagcctcagg gtgaaggggg tcccttgagg gagcgtggag ctgcggtgcc   2820

ctggccggcg atggggagga gccggctccg gcagtgagag gataggcaca gtggaccggg   2880

caggtgtcca ccagcagctc agcccctgca gtcatctcag agccccttcc cgggcctctc   2940

ccccaaggct ccctgcccct cctcatgccc ctctgtcctc tgcgtttttt ctgtgtaatc   3000

tattttttaa gaagagtttg tattattttt tcatacggct gcagcagcag ctgccagggg   3060

cttgggattt tatttttgtg gcgggcgggg gtgggagggc cattttgtca ctttgcctca   3120

gttgagcatc taggaagtat taaaactgtg aagctttctc agtgcacttt gaacctggaa   3180

aacaatccca acaggcccgt gggaccatga cttagggagg tgggacccac ccacccccat   3240

ccaggaaccg tgacgtccaa ggaaccaaac ccagacgcag aacaataaaa taaattccgt   3300

actccccacc c                                                        3311


<210>  3897
<211>  647
<212>  PRT
<213>  Homo sapiens

<400>  3897

Met Arg Leu Thr Leu Leu Cys Cys Thr Trp Arg Glu Glu Arg Met Gly 
1               5                   10                  15


Glu Glu Gly Ser Glu Leu Pro Val Cys Ala Ser Cys Gly Gln Arg Ile 
            20                  25                  30


Tyr Asp Gly Gln Tyr Leu Gln Ala Leu Asn Ala Asp Trp His Ala Asp 
        35                  40                  45


Cys Phe Arg Cys Cys Asp Cys Ser Ala Ser Leu Ser His Gln Tyr Tyr 
    50                  55                  60


Glu Lys Asp Gly Gln Leu Phe Cys Lys Lys Asp Tyr Trp Ala Arg Tyr 
65                  70                  75                  80


Gly Glu Ser Cys His Gly Cys Ser Glu Gln Ile Thr Lys Gly Leu Val 
                85                  90                  95


Met Val Ala Gly Glu Leu Lys Tyr His Pro Glu Cys Phe Ile Cys Leu 
            100                 105                 110


Thr Cys Gly Thr Phe Ile Gly Asp Gly Asp Thr Tyr Thr Leu Val Glu 
        115                 120                 125


His Ser Lys Leu Tyr Cys Gly His Cys Tyr Tyr Gln Thr Val Val Thr 
    130                 135                 140


Pro Val Ile Glu Gln Ile Leu Pro Asp Ser Pro Gly Ser His Leu Pro 
145                 150                 155                 160


His Thr Val Thr Leu Val Ser Ile Pro Ala Ser Ser His Gly Lys Arg 
                165                 170                 175


Gly Leu Ser Val Ser Ile Asp Pro Pro His Gly Pro Pro Gly Cys Gly 
            180                 185                 190


Thr Glu His Ser His Thr Val Arg Val Gln Gly Val Asp Pro Gly Cys 
        195                 200                 205


Met Ser Pro Asp Val Lys Asn Ser Ile His Val Gly Asp Arg Ile Leu 
    210                 215                 220


Glu Ile Asn Gly Thr Pro Ile Arg Asn Val Pro Leu Asp Glu Ile Asp 
225                 230                 235                 240


Leu Leu Ile Gln Glu Thr Ser Arg Leu Leu Gln Leu Thr Leu Glu His 
                245                 250                 255


Asp Pro His Asp Thr Leu Gly His Gly Leu Gly Pro Glu Thr Ser Pro 
            260                 265                 270


Leu Ser Ser Pro Ala Tyr Thr Pro Ser Gly Glu Ala Gly Ser Ser Ala 
        275                 280                 285


Arg Gln Lys Pro Val Leu Arg Ser Cys Ser Ile Asp Arg Ser Pro Gly 
    290                 295                 300


Ala Gly Ser Leu Gly Ser Pro Ala Ser Gln Arg Lys Asp Leu Gly Arg 
305                 310                 315                 320


Ser Glu Ser Leu Arg Val Val Cys Arg Pro His Arg Ile Phe Arg Pro 
                325                 330                 335


Ser Asp Leu Ile His Gly Glu Val Leu Gly Lys Gly Cys Phe Gly Gln 
            340                 345                 350


Ala Ile Lys Val Thr His Arg Glu Thr Gly Glu Val Met Val Met Lys 
        355                 360                 365


Glu Leu Ile Arg Phe Asp Glu Glu Thr Gln Arg Thr Phe Leu Lys Glu 
    370                 375                 380


Val Lys Val Met Arg Cys Leu Glu His Pro Asn Val Leu Lys Phe Ile 
385                 390                 395                 400


Gly Val Leu Tyr Lys Asp Lys Arg Leu Asn Phe Ile Thr Glu Tyr Ile 
                405                 410                 415


Lys Gly Gly Thr Leu Arg Gly Ile Ile Lys Ser Met Asp Ser Gln Tyr 
            420                 425                 430


Pro Trp Ser Gln Arg Val Ser Phe Ala Lys Asp Ile Ala Ser Gly Met 
        435                 440                 445


Ala Tyr Leu His Ser Met Asn Ile Ile His Arg Asp Leu Asn Ser His 
    450                 455                 460


Asn Cys Leu Val Arg Glu Asn Lys Asn Val Val Val Ala Asp Phe Gly 
465                 470                 475                 480


Leu Ala Arg Leu Met Val Asp Glu Lys Thr Gln Pro Glu Gly Leu Arg 
                485                 490                 495


Ser Leu Lys Lys Pro Asp Arg Lys Lys Arg Tyr Thr Val Val Gly Asn 
            500                 505                 510


Pro Tyr Trp Met Ala Pro Glu Met Ile Asn Gly Arg Ser Tyr Asp Glu 
        515                 520                 525


Lys Val Asp Val Phe Ser Phe Gly Ile Val Leu Cys Glu Ile Ile Gly 
    530                 535                 540


Arg Val Asn Ala Asp Pro Asp Tyr Leu Pro Arg Thr Met Asp Phe Gly 
545                 550                 555                 560


Leu Asn Val Arg Gly Phe Leu Asp Arg Tyr Cys Pro Pro Asn Cys Pro 
                565                 570                 575


Pro Ser Phe Phe Pro Ile Thr Val Arg Cys Cys Asp Leu Asp Pro Glu 
            580                 585                 590


Lys Arg Pro Ser Phe Val Lys Leu Glu His Trp Leu Glu Thr Leu Arg 
        595                 600                 605


Met His Leu Ala Gly His Leu Pro Leu Gly Pro Gln Leu Glu Gln Leu 
    610                 615                 620


Asp Arg Gly Phe Trp Glu Thr Tyr Arg Arg Gly Glu Ser Gly Leu Pro 
625                 630                 635                 640


Ala His Pro Glu Val Pro Asp 
                645


<210>  3898
<211>  3350
<212>  DNA
<213>  Homo sapiens

<400>  3898
acaggccccg cctcggtccg cccctccgct cgctccccaa gccgccgcgg cgccgagccg     60

gtttccccgc cggtgtccga gaggcgcccc cggcccggcc gcccccagcc ccagccccgc    120

cgggccccgc cccccgtcga gtgcatgagg ttgacgctac tttgttgcac ctggagggaa    180

gaacgtatgg gagaggaagg aagcgagttg cccgtgtgtg caagctgcgg ccagaggatc    240

tatgatggcc agtacctcca ggccctgaac gcggactggc acgcagactg cttcaggtgt    300

tgtgactgca gtgcctccct gtcgcaccag tactatgaga aggatgggca gctcttctgc    360

aagaaggact actgggcccg ctatggcgag tcctgccatg ggtgctctga gcaaatcacc    420

aagggactgg ttatggtggc tggggagctg aagtaccacc ccgagtgttt catctgcctc    480

acgtgtggga cctttatcgg tgacggggac acctacacgc tggtggagca ctccaagctg    540

tactgcgggc actgctacta ccagactgtg gtgacccccg tcatcgagca gatcctgcct    600

gactcccctg gctcccacct gccccacacc gtcaccctgg tgtccatccc agcctcatct    660

catggcaagc gtggactttc agtctccatt gaccccccgc acggcccacc gggctgtggc    720

accgagcact cacacaccgt ccgcgtccag ggagtggatc cgggctgcat gagcccagat    780

gtgaagaatt ccatccacgt cggagaccgg atcttggaaa tcaatggcac gcccatccga    840

aatgtgcccc tggacgagat tgacctgctg attcaggaaa ccagccgcct gctccagctg    900

accctcgagc atgaccctca cgatacactg ggccacgggc tggggcctga gaccagcccc    960

ctgagctctc cggcttatac tcccagcggg gaggcgggca gctctgcccg gcagaaacct   1020

gtcttgagga gctgcagcat cgacaggtct ccgggcgctg gctcactggg ctccccggcc   1080

tcccagcgca aggacctggg tcgctctgag tccctccgcg tagtctgccg gccacaccgc   1140

atcttccggc cgtcggacct catccacggg gaggtgctgg gcaagggctg cttcggccag   1200

gctatcaagg tgacacaccg tgagacaggt gaggtgatgg tgatgaagga gctgatccgg   1260

ttcgacgagg agacccagag gacgttcctc aaggaggtga aggtcatgcg atgcctggaa   1320

caccccaacg tgctcaagtt catcggggtg ctctacaagg acaagaggct caacttcatc   1380

actgagtaca tcaagggcgg cacgctccgg ggcatcatca agagcatgga cagccagtac   1440

ccatggagcc agagagtgag ctttgccaag gacatcgcat cagggatggc ctacctccac   1500

tccatgaaca tcatccaccg agacctcaac tcccacaact gcctggtccg cgagaacaag   1560

aatgtggtgg tggctgactt cgggctggcg cgtctcatgg tggacgagaa gactcagcct   1620

gagggcctgc ggagcctcaa gaagccagac cgcaagaagc gctacaccgt ggtgggcaac   1680

ccctactgga tggcacctga gatgatcaac ggccgcagct atgatgagaa ggtggatgtg   1740

ttctcctttg ggatcgtcct gtgcgagatc atcgggcggg tgaacgcaga ccctgactac   1800

ctgccccgca ccatggactt tggcctcaac gtgcgaggat tcctggaccg ctactgcccc   1860

ccaaactgcc ccccgagctt cttccccatc accgtgcgct gttgcgatct ggaccccgag   1920

aagaggccat cctttgtgaa gctggaacac tggctggaga ccctccgcat gcacctggcc   1980

ggccacctgc cactgggccc acagctggag cagctggaca gaggtttctg ggagacctac   2040

cggcgcggcg agagcggact gcctgcccac cctgaggtcc ccgactgagc cagggccact   2100

cagctgcccc tgtccccacc tctggagaat ccacccccac cagattcctc cgcgggaggt   2160

ggccctcagc tgggacagtg gggacccagg cttctcctca gagccaggcc ctgacttgcc   2220

ttctcccacc ccgtggaccg cttcccctgc cttctctctg ccgtggccca gagccggccc   2280

agctgcacac acacaccatg ctctcgccct gctgtaacct ctgtcttggc agggctgtcc   2340

cctcttgctt ctccttgcat gagctggagg gcctgtgtga gttacgcccc tttccacacg   2400

ccgctgcccc agcaaccctg ttcacgctcc acctgtctgg tccatagctc cctggaggct   2460

gggccaggag gcagcctccg aaccatgccc catataacgc ttgggtgcgt gggagggcgc   2520

acatcagggc agaggccaag ttccaggtgt ctgtgttccc aggaaccaaa tggggagtct   2580

ggggcccgtt ttccccccag ggggtgtcta ggtagcaaca ggtatcgagg actctccaaa   2640

cccccaaagc agagagaggg ctgatcccat ggggcggagg tccccagtgg ctgagcaaac   2700

agccccttct ctcgctttgg gtcttttttt tgtttctttc ttaaagccac tttagtgaga   2760

agcaggtacc aagcctcagg gtgaaggggg tcccttgagg gagcgtggag ctgcggtgcc   2820

ctggccggcg atggggagga gccggctccg gcagtgagag gataggcaca gtggaccggg   2880

caggtgtcca ccagcagctc agcccctgca gtcatctcag agccccttcc cgggcctctc   2940

ccccaaggct ccctgcccct cctcatgccc ctctgtcctc tgcgtttttt ctgtgtaatc   3000

tattttttaa gaagagtttg tattattttt tcatacggct gcagcagcag ctgccagggg   3060

cttgggattt tatttttgtg gcgggcgggg gtgggagggc cattttgtca ctttgcctca   3120

gttgagcatc taggaagtat taaaactgtg aagctttctc agtgcacttt gaacctggaa   3180

aacaatccca acaggcccgt gggaccatga cttagggagg tgggacccac ccacccccat   3240

ccaggaaccg tgacgtccaa ggaaccaaac ccagacgcag aacaataaaa taaattccgt   3300

actccccacc caggtcctgc gtggcgatgt gtgtctgggg ccctggggaa              3350


<210>  3899
<211>  647
<212>  PRT
<213>  Homo sapiens

<400>  3899

Met Arg Leu Thr Leu Leu Cys Cys Thr Trp Arg Glu Glu Arg Met Gly 
1               5                   10                  15


Glu Glu Gly Ser Glu Leu Pro Val Cys Ala Ser Cys Gly Gln Arg Ile 
            20                  25                  30


Tyr Asp Gly Gln Tyr Leu Gln Ala Leu Asn Ala Asp Trp His Ala Asp 
        35                  40                  45


Cys Phe Arg Cys Cys Asp Cys Ser Ala Ser Leu Ser His Gln Tyr Tyr 
    50                  55                  60


Glu Lys Asp Gly Gln Leu Phe Cys Lys Lys Asp Tyr Trp Ala Arg Tyr 
65                  70                  75                  80


Gly Glu Ser Cys His Gly Cys Ser Glu Gln Ile Thr Lys Gly Leu Val 
                85                  90                  95


Met Val Ala Gly Glu Leu Lys Tyr His Pro Glu Cys Phe Ile Cys Leu 
            100                 105                 110


Thr Cys Gly Thr Phe Ile Gly Asp Gly Asp Thr Tyr Thr Leu Val Glu 
        115                 120                 125


His Ser Lys Leu Tyr Cys Gly His Cys Tyr Tyr Gln Thr Val Val Thr 
    130                 135                 140


Pro Val Ile Glu Gln Ile Leu Pro Asp Ser Pro Gly Ser His Leu Pro 
145                 150                 155                 160


His Thr Val Thr Leu Val Ser Ile Pro Ala Ser Ser His Gly Lys Arg 
                165                 170                 175


Gly Leu Ser Val Ser Ile Asp Pro Pro His Gly Pro Pro Gly Cys Gly 
            180                 185                 190


Thr Glu His Ser His Thr Val Arg Val Gln Gly Val Asp Pro Gly Cys 
        195                 200                 205


Met Ser Pro Asp Val Lys Asn Ser Ile His Val Gly Asp Arg Ile Leu 
    210                 215                 220


Glu Ile Asn Gly Thr Pro Ile Arg Asn Val Pro Leu Asp Glu Ile Asp 
225                 230                 235                 240


Leu Leu Ile Gln Glu Thr Ser Arg Leu Leu Gln Leu Thr Leu Glu His 
                245                 250                 255


Asp Pro His Asp Thr Leu Gly His Gly Leu Gly Pro Glu Thr Ser Pro 
            260                 265                 270


Leu Ser Ser Pro Ala Tyr Thr Pro Ser Gly Glu Ala Gly Ser Ser Ala 
        275                 280                 285


Arg Gln Lys Pro Val Leu Arg Ser Cys Ser Ile Asp Arg Ser Pro Gly 
    290                 295                 300


Ala Gly Ser Leu Gly Ser Pro Ala Ser Gln Arg Lys Asp Leu Gly Arg 
305                 310                 315                 320


Ser Glu Ser Leu Arg Val Val Cys Arg Pro His Arg Ile Phe Arg Pro 
                325                 330                 335


Ser Asp Leu Ile His Gly Glu Val Leu Gly Lys Gly Cys Phe Gly Gln 
            340                 345                 350


Ala Ile Lys Val Thr His Arg Glu Thr Gly Glu Val Met Val Met Lys 
        355                 360                 365


Glu Leu Ile Arg Phe Asp Glu Glu Thr Gln Arg Thr Phe Leu Lys Glu 
    370                 375                 380


Val Lys Val Met Arg Cys Leu Glu His Pro Asn Val Leu Lys Phe Ile 
385                 390                 395                 400


Gly Val Leu Tyr Lys Asp Lys Arg Leu Asn Phe Ile Thr Glu Tyr Ile 
                405                 410                 415


Lys Gly Gly Thr Leu Arg Gly Ile Ile Lys Ser Met Asp Ser Gln Tyr 
            420                 425                 430


Pro Trp Ser Gln Arg Val Ser Phe Ala Lys Asp Ile Ala Ser Gly Met 
        435                 440                 445


Ala Tyr Leu His Ser Met Asn Ile Ile His Arg Asp Leu Asn Ser His 
    450                 455                 460


Asn Cys Leu Val Arg Glu Asn Lys Asn Val Val Val Ala Asp Phe Gly 
465                 470                 475                 480


Leu Ala Arg Leu Met Val Asp Glu Lys Thr Gln Pro Glu Gly Leu Arg 
                485                 490                 495


Ser Leu Lys Lys Pro Asp Arg Lys Lys Arg Tyr Thr Val Val Gly Asn 
            500                 505                 510


Pro Tyr Trp Met Ala Pro Glu Met Ile Asn Gly Arg Ser Tyr Asp Glu 
        515                 520                 525


Lys Val Asp Val Phe Ser Phe Gly Ile Val Leu Cys Glu Ile Ile Gly 
    530                 535                 540


Arg Val Asn Ala Asp Pro Asp Tyr Leu Pro Arg Thr Met Asp Phe Gly 
545                 550                 555                 560


Leu Asn Val Arg Gly Phe Leu Asp Arg Tyr Cys Pro Pro Asn Cys Pro 
                565                 570                 575


Pro Ser Phe Phe Pro Ile Thr Val Arg Cys Cys Asp Leu Asp Pro Glu 
            580                 585                 590


Lys Arg Pro Ser Phe Val Lys Leu Glu His Trp Leu Glu Thr Leu Arg 
        595                 600                 605


Met His Leu Ala Gly His Leu Pro Leu Gly Pro Gln Leu Glu Gln Leu 
    610                 615                 620


Asp Arg Gly Phe Trp Glu Thr Tyr Arg Arg Gly Glu Ser Gly Leu Pro 
625                 630                 635                 640


Ala His Pro Glu Val Pro Asp 
                645


<210>  3900
<211>  3367
<212>  DNA
<213>  Homo sapiens

<400>  3900
ggtccgcccc tccgctcgct ccccaagccg ccgcggcgcc gagccggttt ccccgccggt     60

gtccgagagg cgcccccggc ccggcccggc ccggcccgcg ccctccgccc ccgcctcccc    120

gggccggcgg cggtgggcga gctcgcgggc ccggccgccc ccagccccag ccccgccggg    180

ccccgccccc cgtcgagtgc atgaggttga cgctactttg ttgcacctgg agggaagaac    240

gtatgggaga ggaaggaagc gagttgcccg tgtgtgcaag ctgcggccag aggatctatg    300

atggccagta cctccaggcc ctgaacgcgg actggcacgc agactgcttc aggtgttgtg    360

actgcagtgc ctccctgtcg caccagtact atgagaagga tgggcagctc ttctgcaaga    420

aggactactg ggcccgctat ggcgagtcct gccatgggtg ctctgagcaa atcaccaagg    480

gactggttat ggtggctggg gagctgaagt accaccccga gtgtttcatc tgcctcacgt    540

gtgggacctt tatcggtgac ggggacacct acacgctggt ggagcactcc aagctgtact    600

gcgggcactg ctactaccag actgtggtga cccccgtcat cgagcagatc ctgcctgact    660

cccctggctc ccacctgccc cacaccgtca ccctggtgtc catcccagcc tcatctcatg    720

gcaagcgtgg actttcagtc tccattgacc ccccgcacgg cccaccgggc tgtggcaccg    780

agcactcaca caccgtccgc gtccagggag tggatccggg ctgcatgagc ccagatgtga    840

agaattccat ccacgtcgga gaccggatct tggaaatcaa tggcacgccc atccgaaatg    900

tgcccctgga cgagattgac ctgctgattc aggaaaccag ccgcctgctc cagctgaccc    960

tcgagcatga ccctcacgat acactgggcc acgggctggg gcctgagacc agccccctga   1020

gctctccggc ttatactccc agcggggagg cgggcagctc tgcccggcag aaacctgtct   1080

tgaggagctg cagcatcgac aggtctccgg gcgctggctc actgggctcc ccggcctccc   1140

agcgcaagga cctgggtcgc tctgagtccc tccgcgtagt ctgccggcca caccgcatct   1200

tccggccgtc ggacctcatc cacggggagg tgctgggcaa gggctgcttc ggccaggcta   1260

tcaaggtgac acaccgtgag acaggtgagg tgatggtgat gaaggagctg atccggttcg   1320

acgaggagac ccagaggacg ttcctcaagg aggtgaaggt catgcgatgc ctggaacacc   1380

ccaacgtgct caagttcatc ggggtgctct acaaggacaa gaggctcaac ttcatcactg   1440

agtacatcaa gggcggcacg ctccggggca tcatcaagag catggacagc cagtacccat   1500

ggagccagag agtgagcttt gccaaggaca tcgcatcagg gatggcctac ctccactcca   1560

tgaacatcat ccaccgagac ctcaactccc acaactgcct ggtccgcgag aacaagaatg   1620

tggtggtggc tgacttcggg ctggcgcgtc tcatggtgga cgagaagact cagcctgagg   1680

gcctgcggag cctcaagaag ccagaccgca agaagcgcta caccgtggtg ggcaacccct   1740

actggatggc acctgagatg atcaacggcc gcagctatga tgagaaggtg gatgtgttct   1800

cctttgggat cgtcctgtgc gagatcatcg ggcgggtgaa cgcagaccct gactacctgc   1860

cccgcaccat ggactttggc ctcaacgtgc gaggattcct ggaccgctac tgccccccaa   1920

actgcccccc gagcttcttc cccatcaccg tgcgctgttg cgatctggac cccgagaaga   1980

ggccatcctt tgtgaagctg gaacactggc tggagaccct ccgcatgcac ctggccggcc   2040

acctgccact gggcccacag ctggagcagc tggacagagg tttctgggag acctaccggc   2100

gcggcgagag cggactgcct gcccaccctg aggtccccga ctgagccagg gccactcagc   2160

tgcccctgtc cccacctctg gagaatccac ccccaccaga ttcctccgcg ggaggtggcc   2220

ctcagctggg acagtgggga cccaggcttc tcctcagagc caggccctga cttgccttct   2280

cccaccccgt ggaccgcttc ccctgccttc tctctgccgt ggcccagagc cggcccagct   2340

gcacacacac accatgctct cgccctgctg taacctctgt cttggcaggg ctgtcccctc   2400

ttgcttctcc ttgcatgagc tggagggcct gtgtgagtta cgcccctttc cacacgccgc   2460

tgccccagca accctgttca cgctccacct gtctggtcca tagctccctg gaggctgggc   2520

caggaggcag cctccgaacc atgccccata taacgcttgg gtgcgtggga gggcgcacat   2580

cagggcagag gccaagttcc aggtgtctgt gttcccagga accaaatggg gagtctgggg   2640

cccgttttcc ccccaggggg tgtctaggta gcaacaggta tcgaggactc tccaaacccc   2700

caaagcagag agagggctga tcccatgggg cggaggtccc cagtggctga gcaaacagcc   2760

ccttctctcg ctttgggtct tttttttgtt tctttcttaa agccacttta gtgagaagca   2820

ggtaccaagc ctcagggtga agggggtccc ttgagggagc gtggagctgc ggtgccctgg   2880

ccggcgatgg ggaggagccg gctccggcag tgagaggata ggcacagtgg accgggcagg   2940

tgtccaccag cagctcagcc cctgcagtca tctcagagcc ccttcccggg cctctccccc   3000

aaggctccct gcccctcctc atgcccctct gtcctctgcg ttttttctgt gtaatctatt   3060

ttttaagaag agtttgtatt attttttcat acggctgcag cagcagctgc caggggcttg   3120

ggattttatt tttgtggcgg gcgggggtgg gagggccatt ttgtcacttt gcctcagttg   3180

agcatctagg aagtattaaa actgtgaagc tttctcagtg cactttgaac ctggaaaaca   3240

atcccaacag gcccgtggga ccatgactta gggaggtggg acccacccac ccccatccag   3300

gaaccgtgac gtccaaggaa ccaaacccag acgcagaaca ataaaataaa ttccgtactc   3360

cccaccc                                                             3367


<210>  3901
<211>  647
<212>  PRT
<213>  Homo sapiens

<400>  3901

Met Arg Leu Thr Leu Leu Cys Cys Thr Trp Arg Glu Glu Arg Met Gly 
1               5                   10                  15


Glu Glu Gly Ser Glu Leu Pro Val Cys Ala Ser Cys Gly Gln Arg Ile 
            20                  25                  30


Tyr Asp Gly Gln Tyr Leu Gln Ala Leu Asn Ala Asp Trp His Ala Asp 
        35                  40                  45


Cys Phe Arg Cys Cys Asp Cys Ser Ala Ser Leu Ser His Gln Tyr Tyr 
    50                  55                  60


Glu Lys Asp Gly Gln Leu Phe Cys Lys Lys Asp Tyr Trp Ala Arg Tyr 
65                  70                  75                  80


Gly Glu Ser Cys His Gly Cys Ser Glu Gln Ile Thr Lys Gly Leu Val 
                85                  90                  95


Met Val Ala Gly Glu Leu Lys Tyr His Pro Glu Cys Phe Ile Cys Leu 
            100                 105                 110


Thr Cys Gly Thr Phe Ile Gly Asp Gly Asp Thr Tyr Thr Leu Val Glu 
        115                 120                 125


His Ser Lys Leu Tyr Cys Gly His Cys Tyr Tyr Gln Thr Val Val Thr 
    130                 135                 140


Pro Val Ile Glu Gln Ile Leu Pro Asp Ser Pro Gly Ser His Leu Pro 
145                 150                 155                 160


His Thr Val Thr Leu Val Ser Ile Pro Ala Ser Ser His Gly Lys Arg 
                165                 170                 175


Gly Leu Ser Val Ser Ile Asp Pro Pro His Gly Pro Pro Gly Cys Gly 
            180                 185                 190


Thr Glu His Ser His Thr Val Arg Val Gln Gly Val Asp Pro Gly Cys 
        195                 200                 205


Met Ser Pro Asp Val Lys Asn Ser Ile His Val Gly Asp Arg Ile Leu 
    210                 215                 220


Glu Ile Asn Gly Thr Pro Ile Arg Asn Val Pro Leu Asp Glu Ile Asp 
225                 230                 235                 240


Leu Leu Ile Gln Glu Thr Ser Arg Leu Leu Gln Leu Thr Leu Glu His 
                245                 250                 255


Asp Pro His Asp Thr Leu Gly His Gly Leu Gly Pro Glu Thr Ser Pro 
            260                 265                 270


Leu Ser Ser Pro Ala Tyr Thr Pro Ser Gly Glu Ala Gly Ser Ser Ala 
        275                 280                 285


Arg Gln Lys Pro Val Leu Arg Ser Cys Ser Ile Asp Arg Ser Pro Gly 
    290                 295                 300


Ala Gly Ser Leu Gly Ser Pro Ala Ser Gln Arg Lys Asp Leu Gly Arg 
305                 310                 315                 320


Ser Glu Ser Leu Arg Val Val Cys Arg Pro His Arg Ile Phe Arg Pro 
                325                 330                 335


Ser Asp Leu Ile His Gly Glu Val Leu Gly Lys Gly Cys Phe Gly Gln 
            340                 345                 350


Ala Ile Lys Val Thr His Arg Glu Thr Gly Glu Val Met Val Met Lys 
        355                 360                 365


Glu Leu Ile Arg Phe Asp Glu Glu Thr Gln Arg Thr Phe Leu Lys Glu 
    370                 375                 380


Val Lys Val Met Arg Cys Leu Glu His Pro Asn Val Leu Lys Phe Ile 
385                 390                 395                 400


Gly Val Leu Tyr Lys Asp Lys Arg Leu Asn Phe Ile Thr Glu Tyr Ile 
                405                 410                 415


Lys Gly Gly Thr Leu Arg Gly Ile Ile Lys Ser Met Asp Ser Gln Tyr 
            420                 425                 430


Pro Trp Ser Gln Arg Val Ser Phe Ala Lys Asp Ile Ala Ser Gly Met 
        435                 440                 445


Ala Tyr Leu His Ser Met Asn Ile Ile His Arg Asp Leu Asn Ser His 
    450                 455                 460


Asn Cys Leu Val Arg Glu Asn Lys Asn Val Val Val Ala Asp Phe Gly 
465                 470                 475                 480


Leu Ala Arg Leu Met Val Asp Glu Lys Thr Gln Pro Glu Gly Leu Arg 
                485                 490                 495


Ser Leu Lys Lys Pro Asp Arg Lys Lys Arg Tyr Thr Val Val Gly Asn 
            500                 505                 510


Pro Tyr Trp Met Ala Pro Glu Met Ile Asn Gly Arg Ser Tyr Asp Glu 
        515                 520                 525


Lys Val Asp Val Phe Ser Phe Gly Ile Val Leu Cys Glu Ile Ile Gly 
    530                 535                 540


Arg Val Asn Ala Asp Pro Asp Tyr Leu Pro Arg Thr Met Asp Phe Gly 
545                 550                 555                 560


Leu Asn Val Arg Gly Phe Leu Asp Arg Tyr Cys Pro Pro Asn Cys Pro 
                565                 570                 575


Pro Ser Phe Phe Pro Ile Thr Val Arg Cys Cys Asp Leu Asp Pro Glu 
            580                 585                 590


Lys Arg Pro Ser Phe Val Lys Leu Glu His Trp Leu Glu Thr Leu Arg 
        595                 600                 605


Met His Leu Ala Gly His Leu Pro Leu Gly Pro Gln Leu Glu Gln Leu 
    610                 615                 620


Asp Arg Gly Phe Trp Glu Thr Tyr Arg Arg Gly Glu Ser Gly Leu Pro 
625                 630                 635                 640


Ala His Pro Glu Val Pro Asp 
                645


<210>  3902
<211>  3306
<212>  DNA
<213>  Homo sapiens

<400>  3902
ggtccgcccc tccgctcgct ccccaagccg ccgcggcgcc gagccggttt ccccgccggt     60

gtccgagagg cgcccccggc ccggcccggc ccggcccgcg ccctccgccc ccgcctcccc    120

gggccggcgg cggtgggcga gctcgcgggc ccggccgccc ccagccccag ccccgccggg    180

ccccgccccc cgtcgagtgc atgaggttga cgctactttg ttgcacctgg agggaagaac    240

gtatgggaga ggaaggaagc gagttgcccg tgtgtgcaag ctgcggccag aggatctatg    300

atggccagta cctccaggcc ctgaacgcgg actggcacgc agactgcttc aggtgttgtg    360

actgcagtgc ctccctgtcg caccagtact atgagaagga tgggcagctc ttctgcaaga    420

aggactactg ggcccgctat ggcgagtcct gccatgggtg ctctgagcaa atcaccaagg    480

gactggttat ggtggctggg gagctgaagt accaccccga gtgtttcatc tgcctcacgt    540

gtgggacctt tatcggtgac ggggacacct acacgctggt ggagcactcc aagctgtact    600

gcgggcactg ctactaccag actgtggtga cccccgtcat cgagcagatc ctgcctgact    660

cccctggctc ccacctgccc cacaccgtca ccctggtgtc catcccagcc tcatctcatg    720

gcaagcgtgg actttcagtc tccattgacc ccccgcacgg cccaccgggc tgtggcaccg    780

agcactcaca caccgtccgc gtccagggag tggatccggg ctgcatgagc ccagatgtga    840

agaattccat ccacgtcgga gaccggatct tggaaatcaa tggcacgccc atccgaaatg    900

tgcccctgga cgagattgac ctgctgattc aggaaaccag ccgcctgctc cagctgaccc    960

tcgagcatga ccctcacgat acactgggcc acgggctggg gcctgagacc agccccctga   1020

gctctccggc ttatactccc agcggggagg cgggcagctc tgcccggcag aaacctgtct   1080

tcgcaaggac ctgggtcgct ctgagtccct ccgcgtagtc tgccggccac accgcatctt   1140

ccggccgtcg gacctcatcc acggggaggt gctgggcaag ggctgcttcg gccaggctat   1200

caaggtgaca caccgtgaga caggtgaggt gatggtgatg aaggagctga tccggttcga   1260

cgaggagacc cagaggacgt tcctcaagga ggtgaaggtc atgcgatgcc tggaacaccc   1320

caacgtgctc aagttcatcg gggtgctcta caaggacaag aggctcaact tcatcactga   1380

gtacatcaag ggcggcacgc tccggggcat catcaagagc atggacagcc agtacccatg   1440

gagccagaga gtgagctttg ccaaggacat cgcatcaggg atggcctacc tccactccat   1500

gaacatcatc caccgagacc tcaactccca caactgcctg gtccgcgaga acaagaatgt   1560

ggtggtggct gacttcgggc tggcgcgtct catggtggac gagaagactc agcctgaggg   1620

cctgcggagc ctcaagaagc cagaccgcaa gaagcgctac accgtggtgg gcaaccccta   1680

ctggatggca cctgagatga tcaacggccg cagctatgat gagaaggtgg atgtgttctc   1740

ctttgggatc gtcctgtgcg agatcatcgg gcgggtgaac gcagaccctg actacctgcc   1800

ccgcaccatg gactttggcc tcaacgtgcg aggattcctg gaccgctact gccccccaaa   1860

ctgccccccg agcttcttcc ccatcaccgt gcgctgttgc gatctggacc ccgagaagag   1920

gccatccttt gtgaagctgg aacactggct ggagaccctc cgcatgcacc tggccggcca   1980

cctgccactg ggcccacagc tggagcagct ggacagaggt ttctgggaga cctaccggcg   2040

cggcgagagc ggactgcctg cccaccctga ggtccccgac tgagccaggg ccactcagct   2100

gcccctgtcc ccacctctgg agaatccacc cccaccagat tcctccgcgg gaggtggccc   2160

tcagctggga cagtggggac ccaggcttct cctcagagcc aggccctgac ttgccttctc   2220

ccaccccgtg gaccgcttcc cctgccttct ctctgccgtg gcccagagcc ggcccagctg   2280

cacacacaca ccatgctctc gccctgctgt aacctctgtc ttggcagggc tgtcccctct   2340

tgcttctcct tgcatgagct ggagggcctg tgtgagttac gcccctttcc acacgccgct   2400

gccccagcaa ccctgttcac gctccacctg tctggtccat agctccctgg aggctgggcc   2460

aggaggcagc ctccgaacca tgccccatat aacgcttggg tgcgtgggag ggcgcacatc   2520

agggcagagg ccaagttcca ggtgtctgtg ttcccaggaa ccaaatgggg agtctggggc   2580

ccgttttccc cccagggggt gtctaggtag caacaggtat cgaggactct ccaaaccccc   2640

aaagcagaga gagggctgat cccatggggc ggaggtcccc agtggctgag caaacagccc   2700

cttctctcgc tttgggtctt ttttttgttt ctttcttaaa gccactttag tgagaagcag   2760

gtaccaagcc tcagggtgaa gggggtccct tgagggagcg tggagctgcg gtgccctggc   2820

cggcgatggg gaggagccgg ctccggcagt gagaggatag gcacagtgga ccgggcaggt   2880

gtccaccagc agctcagccc ctgcagtcat ctcagagccc cttcccgggc ctctccccca   2940

aggctccctg cccctcctca tgcccctctg tcctctgcgt tttttctgtg taatctattt   3000

tttaagaaga gtttgtatta ttttttcata cggctgcagc agcagctgcc aggggcttgg   3060

gattttattt ttgtggcggg cgggggtggg agggccattt tgtcactttg cctcagttga   3120

gcatctagga agtattaaaa ctgtgaagct ttctcagtgc actttgaacc tggaaaacaa   3180

tcccaacagg cccgtgggac catgacttag ggaggtggga cccacccacc cccatccagg   3240

aaccgtgacg tccaaggaac caaacccaga cgcagaacaa taaaataaat tccgtactcc   3300

ccaccc                                                              3306


<210>  3903
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  3903

Met Arg Leu Thr Leu Leu Cys Cys Thr Trp Arg Glu Glu Arg Met Gly 
1               5                   10                  15


Glu Glu Gly Ser Glu Leu Pro Val Cys Ala Ser Cys Gly Gln Arg Ile 
            20                  25                  30


Tyr Asp Gly Gln Tyr Leu Gln Ala Leu Asn Ala Asp Trp His Ala Asp 
        35                  40                  45


Cys Phe Arg Cys Cys Asp Cys Ser Ala Ser Leu Ser His Gln Tyr Tyr 
    50                  55                  60


Glu Lys Asp Gly Gln Leu Phe Cys Lys Lys Asp Tyr Trp Ala Arg Tyr 
65                  70                  75                  80


Gly Glu Ser Cys His Gly Cys Ser Glu Gln Ile Thr Lys Gly Leu Val 
                85                  90                  95


Met Val Ala Gly Glu Leu Lys Tyr His Pro Glu Cys Phe Ile Cys Leu 
            100                 105                 110


Thr Cys Gly Thr Phe Ile Gly Asp Gly Asp Thr Tyr Thr Leu Val Glu 
        115                 120                 125


His Ser Lys Leu Tyr Cys Gly His Cys Tyr Tyr Gln Thr Val Val Thr 
    130                 135                 140


Pro Val Ile Glu Gln Ile Leu Pro Asp Ser Pro Gly Ser His Leu Pro 
145                 150                 155                 160


His Thr Val Thr Leu Val Ser Ile Pro Ala Ser Ser His Gly Lys Arg 
                165                 170                 175


Gly Leu Ser Val Ser Ile Asp Pro Pro His Gly Pro Pro Gly Cys Gly 
            180                 185                 190


Thr Glu His Ser His Thr Val Arg Val Gln Gly Val Asp Pro Gly Cys 
        195                 200                 205


Met Ser Pro Asp Val Lys Asn Ser Ile His Val Gly Asp Arg Ile Leu 
    210                 215                 220


Glu Ile Asn Gly Thr Pro Ile Arg Asn Val Pro Leu Asp Glu Ile Asp 
225                 230                 235                 240


Leu Leu Ile Gln Glu Thr Ser Arg Leu Leu Gln Leu Thr Leu Glu His 
                245                 250                 255


Asp Pro His Asp Thr Leu Gly His Gly Leu Gly Pro Glu Thr Ser Pro 
            260                 265                 270


Leu Ser Ser Pro Ala Tyr Thr Pro Ser Gly Glu Ala Gly Ser Ser Ala 
        275                 280                 285


Arg Gln Lys Pro Val Phe Ala Arg Thr Trp Val Ala Leu Ser Pro Ser 
    290                 295                 300


Ala 
305


<210>  3904
<211>  3345
<212>  DNA
<213>  Homo sapiens

<400>  3904
ggtccgcccc tccgctcgct ccccaagccg ccgcggcgcc gagccggttt ccccgccggt     60

gtccgagagg cgcccccggc ccggcccggc ccggcccgcg ccctccgccc ccgcctcccc    120

gggccggcgg cggtgggcga gctcgcgggc ccggccgccc ccagccccag ccccgccggg    180

ccccgccccc cgtcgagtgc atgaggttga cgctactttg ttgcacctgg agggaagaac    240

gtatgggaga ggaaggaagc gagttgcccg tgtgtgcaag ctgcggccag aggatctatg    300

atggccagta cctccaggcc ctgaacgcgg actggcacgc agactgcttc aggtgttgtg    360

actgcagtgc ctccctgtcg caccagtact atgagaagga tgggcagctc ttctgcaaga    420

aggactactg ggcccgctat ggcgagtcct gccatgggtg ctctgagcaa atcaccaagg    480

gactggttat ggtggctggg gagctgaagt accaccccga gtgtttcatc tgcctcacgt    540

gtgggacctt tatcggtgac ggggacacct acacgctggt ggagcactcc aagctgtact    600

gcgggcactg ctactaccag actgtggtga cccccgtcat cgagcagatc ctgcctgact    660

cccctggctc ccacctgccc cacaccgtca ccctggtgtc catcccagcc tcatctcatg    720

gcaagcgtgg actttcagtc tccattgacc ccccgcacgg cccaccgggc tgtggcaccg    780

agcactcaca caccgtccgc gtccagggag tggatccggg ctgcatgagc ccagatgtga    840

agaattccat ccacgtcgga gaccggatct tggaaatcaa tggcacgccc atccgaaatg    900

tgcccctgga cgagattgac ctgctgattc aggaaaccag ccgcctgctc cagctgaccc    960

tcgagcatga ccctcacgat acactgggcc acgggctggg gcctgagacc agccccctga   1020

gctctccggc ttatactccc agcggggagg cgggcagctc tgcccggcag aaacctgtct   1080

tcgcaaggac ctgggtcgct ctgagtccct ccgcgtagtc tgccggccac accgcatctt   1140

ccggccgtcg gacctcatcc acggggaggt gctgggcaag ggctgcttcg gccaggctat   1200

caaggtgaca caccgtgaga caggtgaggt gatggtgatg aaggagctga tccggttcga   1260

cgaggagacc cagaggacgt tcctcaagga ggtgaaggtc atgcgatgcc tggaacaccc   1320

caacgtgctc aagttcatcg gggtgctcta caaggacaag aggctcaact tcatcactga   1380

gtacatcaag ggcggcacgc tccggggcat catcaagagc atggacagcc agtacccatg   1440

gagccagaga gtgagctttg ccaaggacat cgcatcaggg atggcctacc tccactccat   1500

gaacatcatc caccgagacc tcaactccca caactgcctg gtccgcgaga acaagaatgt   1560

ggtggtggct gacttcgggc tggcgcgtct catggtggac gagaagactc agcctgaggg   1620

cctgcggagc ctcaagaagc cagaccgcaa gaagcgctac accgtggtgg gcaaccccta   1680

ctggatggca cctgagatga tcaacggccg cagctatgat gagaaggtgg atgtgttctc   1740

ctttgggatc gtcctgtgcg agatcatcgg gcgggtgaac gcagaccctg actacctgcc   1800

ccgcaccatg gactttggcc tcaacgtgcg aggattcctg gaccgctact gccccccaaa   1860

ctgccccccg agcttcttcc ccatcaccgt gcgctgttgc gatctggacc ccgagaagag   1920

gccatccttt gtgaagctgg aacactggct ggagaccctc cgcatgcacc tggccggcca   1980

cctgccactg ggcccacagc tggagcagct ggacagaggt ttctgggaga cctaccggcg   2040

cggcgagagc ggactgcctg cccaccctga ggtccccgac tgagccaggg ccactcagct   2100

gcccctgtcc ccacctctgg agaatccacc cccaccagat tcctccgcgg gaggtggccc   2160

tcagctggga cagtggggac ccaggcttct cctcagagcc aggccctgac ttgccttctc   2220

ccaccccgtg gaccgcttcc cctgccttct ctctgccgtg gcccagagcc ggcccagctg   2280

cacacacaca ccatgctctc gccctgctgt aacctctgtc ttggcagggc tgtcccctct   2340

tgcttctcct tgcatgagct ggagggcctg tgtgagttac gcccctttcc acacgccgct   2400

gccccagcaa ccctgttcac gctccacctg tctggtccat agctccctgg aggctgggcc   2460

aggaggcagc ctccgaacca tgccccatat aacgcttggg tgcgtgggag ggcgcacatc   2520

agggcagagg ccaagttcca ggtgtctgtg ttcccaggaa ccaaatgggg agtctggggc   2580

ccgttttccc cccagggggt gtctaggtag caacaggtat cgaggactct ccaaaccccc   2640

aaagcagaga gagggctgat cccatggggc ggaggtcccc agtggctgag caaacagccc   2700

cttctctcgc tttgggtctt ttttttgttt ctttcttaaa gccactttag tgagaagcag   2760

gtaccaagcc tcagggtgaa gggggtccct tgagggagcg tggagctgcg gtgccctggc   2820

cggcgatggg gaggagccgg ctccggcagt gagaggatag gcacagtgga ccgggcaggt   2880

gtccaccagc agctcagccc ctgcagtcat ctcagagccc cttcccgggc ctctccccca   2940

aggctccctg cccctcctca tgcccctctg tcctctgcgt tttttctgtg taatctattt   3000

tttaagaaga gtttgtatta ttttttcata cggctgcagc agcagctgcc aggggcttgg   3060

gattttattt ttgtggcggg cgggggtggg agggccattt tgtcactttg cctcagttga   3120

gcatctagga agtattaaaa ctgtgaagct ttctcagtgc actttgaacc tggaaaacaa   3180

tcccaacagg cccgtgggac catgacttag ggaggtggga cccacccacc cccatccagg   3240

aaccgtgacg tccaaggaac caaacccaga cgcagaacaa taaaataaat tccgtactcc   3300

ccacccaggt cctgcgtggc gatgtgtgtc tggggccctg gggaa                   3345


<210>  3905
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  3905

Met Arg Leu Thr Leu Leu Cys Cys Thr Trp Arg Glu Glu Arg Met Gly 
1               5                   10                  15


Glu Glu Gly Ser Glu Leu Pro Val Cys Ala Ser Cys Gly Gln Arg Ile 
            20                  25                  30


Tyr Asp Gly Gln Tyr Leu Gln Ala Leu Asn Ala Asp Trp His Ala Asp 
        35                  40                  45


Cys Phe Arg Cys Cys Asp Cys Ser Ala Ser Leu Ser His Gln Tyr Tyr 
    50                  55                  60


Glu Lys Asp Gly Gln Leu Phe Cys Lys Lys Asp Tyr Trp Ala Arg Tyr 
65                  70                  75                  80


Gly Glu Ser Cys His Gly Cys Ser Glu Gln Ile Thr Lys Gly Leu Val 
                85                  90                  95


Met Val Ala Gly Glu Leu Lys Tyr His Pro Glu Cys Phe Ile Cys Leu 
            100                 105                 110


Thr Cys Gly Thr Phe Ile Gly Asp Gly Asp Thr Tyr Thr Leu Val Glu 
        115                 120                 125


His Ser Lys Leu Tyr Cys Gly His Cys Tyr Tyr Gln Thr Val Val Thr 
    130                 135                 140


Pro Val Ile Glu Gln Ile Leu Pro Asp Ser Pro Gly Ser His Leu Pro 
145                 150                 155                 160


His Thr Val Thr Leu Val Ser Ile Pro Ala Ser Ser His Gly Lys Arg 
                165                 170                 175


Gly Leu Ser Val Ser Ile Asp Pro Pro His Gly Pro Pro Gly Cys Gly 
            180                 185                 190


Thr Glu His Ser His Thr Val Arg Val Gln Gly Val Asp Pro Gly Cys 
        195                 200                 205


Met Ser Pro Asp Val Lys Asn Ser Ile His Val Gly Asp Arg Ile Leu 
    210                 215                 220


Glu Ile Asn Gly Thr Pro Ile Arg Asn Val Pro Leu Asp Glu Ile Asp 
225                 230                 235                 240


Leu Leu Ile Gln Glu Thr Ser Arg Leu Leu Gln Leu Thr Leu Glu His 
                245                 250                 255


Asp Pro His Asp Thr Leu Gly His Gly Leu Gly Pro Glu Thr Ser Pro 
            260                 265                 270


Leu Ser Ser Pro Ala Tyr Thr Pro Ser Gly Glu Ala Gly Ser Ser Ala 
        275                 280                 285


Arg Gln Lys Pro Val Phe Ala Arg Thr Trp Val Ala Leu Ser Pro Ser 
    290                 295                 300


Ala 
305


<210>  3906
<211>  3406
<212>  DNA
<213>  Homo sapiens

<400>  3906
ggtccgcccc tccgctcgct ccccaagccg ccgcggcgcc gagccggttt ccccgccggt     60

gtccgagagg cgcccccggc ccggcccggc ccggcccgcg ccctccgccc ccgcctcccc    120

gggccggcgg cggtgggcga gctcgcgggc ccggccgccc ccagccccag ccccgccggg    180

ccccgccccc cgtcgagtgc atgaggttga cgctactttg ttgcacctgg agggaagaac    240

gtatgggaga ggaaggaagc gagttgcccg tgtgtgcaag ctgcggccag aggatctatg    300

atggccagta cctccaggcc ctgaacgcgg actggcacgc agactgcttc aggtgttgtg    360

actgcagtgc ctccctgtcg caccagtact atgagaagga tgggcagctc ttctgcaaga    420

aggactactg ggcccgctat ggcgagtcct gccatgggtg ctctgagcaa atcaccaagg    480

gactggttat ggtggctggg gagctgaagt accaccccga gtgtttcatc tgcctcacgt    540

gtgggacctt tatcggtgac ggggacacct acacgctggt ggagcactcc aagctgtact    600

gcgggcactg ctactaccag actgtggtga cccccgtcat cgagcagatc ctgcctgact    660

cccctggctc ccacctgccc cacaccgtca ccctggtgtc catcccagcc tcatctcatg    720

gcaagcgtgg actttcagtc tccattgacc ccccgcacgg cccaccgggc tgtggcaccg    780

agcactcaca caccgtccgc gtccagggag tggatccggg ctgcatgagc ccagatgtga    840

agaattccat ccacgtcgga gaccggatct tggaaatcaa tggcacgccc atccgaaatg    900

tgcccctgga cgagattgac ctgctgattc aggaaaccag ccgcctgctc cagctgaccc    960

tcgagcatga ccctcacgat acactgggcc acgggctggg gcctgagacc agccccctga   1020

gctctccggc ttatactccc agcggggagg cgggcagctc tgcccggcag aaacctgtct   1080

tgaggagctg cagcatcgac aggtctccgg gcgctggctc actgggctcc ccggcctccc   1140

agcgcaagga cctgggtcgc tctgagtccc tccgcgtagt ctgccggcca caccgcatct   1200

tccggccgtc ggacctcatc cacggggagg tgctgggcaa gggctgcttc ggccaggcta   1260

tcaaggtgac acaccgtgag acaggtgagg tgatggtgat gaaggagctg atccggttcg   1320

acgaggagac ccagaggacg ttcctcaagg aggtgaaggt catgcgatgc ctggaacacc   1380

ccaacgtgct caagttcatc ggggtgctct acaaggacaa gaggctcaac ttcatcactg   1440

agtacatcaa gggcggcacg ctccggggca tcatcaagag catggacagc cagtacccat   1500

ggagccagag agtgagcttt gccaaggaca tcgcatcagg gatggcctac ctccactcca   1560

tgaacatcat ccaccgagac ctcaactccc acaactgcct ggtccgcgag aacaagaatg   1620

tggtggtggc tgacttcggg ctggcgcgtc tcatggtgga cgagaagact cagcctgagg   1680

gcctgcggag cctcaagaag ccagaccgca agaagcgcta caccgtggtg ggcaacccct   1740

actggatggc acctgagatg atcaacggcc gcagctatga tgagaaggtg gatgtgttct   1800

cctttgggat cgtcctgtgc gagatcatcg ggcgggtgaa cgcagaccct gactacctgc   1860

cccgcaccat ggactttggc ctcaacgtgc gaggattcct ggaccgctac tgccccccaa   1920

actgcccccc gagcttcttc cccatcaccg tgcgctgttg cgatctggac cccgagaaga   1980

ggccatcctt tgtgaagctg gaacactggc tggagaccct ccgcatgcac ctggccggcc   2040

acctgccact gggcccacag ctggagcagc tggacagagg tttctgggag acctaccggc   2100

gcggcgagag cggactgcct gcccaccctg aggtccccga ctgagccagg gccactcagc   2160

tgcccctgtc cccacctctg gagaatccac ccccaccaga ttcctccgcg ggaggtggcc   2220

ctcagctggg acagtgggga cccaggcttc tcctcagagc caggccctga cttgccttct   2280

cccaccccgt ggaccgcttc ccctgccttc tctctgccgt ggcccagagc cggcccagct   2340

gcacacacac accatgctct cgccctgctg taacctctgt cttggcaggg ctgtcccctc   2400

ttgcttctcc ttgcatgagc tggagggcct gtgtgagtta cgcccctttc cacacgccgc   2460

tgccccagca accctgttca cgctccacct gtctggtcca tagctccctg gaggctgggc   2520

caggaggcag cctccgaacc atgccccata taacgcttgg gtgcgtggga gggcgcacat   2580

cagggcagag gccaagttcc aggtgtctgt gttcccagga accaaatggg gagtctgggg   2640

cccgttttcc ccccaggggg tgtctaggta gcaacaggta tcgaggactc tccaaacccc   2700

caaagcagag agagggctga tcccatgggg cggaggtccc cagtggctga gcaaacagcc   2760

ccttctctcg ctttgggtct tttttttgtt tctttcttaa agccacttta gtgagaagca   2820

ggtaccaagc ctcagggtga agggggtccc ttgagggagc gtggagctgc ggtgccctgg   2880

ccggcgatgg ggaggagccg gctccggcag tgagaggata ggcacagtgg accgggcagg   2940

tgtccaccag cagctcagcc cctgcagtca tctcagagcc ccttcccggg cctctccccc   3000

aaggctccct gcccctcctc atgcccctct gtcctctgcg ttttttctgt gtaatctatt   3060

ttttaagaag agtttgtatt attttttcat acggctgcag cagcagctgc caggggcttg   3120

ggattttatt tttgtggcgg gcgggggtgg gagggccatt ttgtcacttt gcctcagttg   3180

agcatctagg aagtattaaa actgtgaagc tttctcagtg cactttgaac ctggaaaaca   3240

atcccaacag gcccgtggga ccatgactta gggaggtggg acccacccac ccccatccag   3300

gaaccgtgac gtccaaggaa ccaaacccag acgcagaaca ataaaataaa ttccgtactc   3360

cccacccagg tcctgcgtgg cgatgtgtgt ctggggccct ggggaa                  3406


<210>  3907
<211>  647
<212>  PRT
<213>  Homo sapiens

<400>  3907

Met Arg Leu Thr Leu Leu Cys Cys Thr Trp Arg Glu Glu Arg Met Gly 
1               5                   10                  15


Glu Glu Gly Ser Glu Leu Pro Val Cys Ala Ser Cys Gly Gln Arg Ile 
            20                  25                  30


Tyr Asp Gly Gln Tyr Leu Gln Ala Leu Asn Ala Asp Trp His Ala Asp 
        35                  40                  45


Cys Phe Arg Cys Cys Asp Cys Ser Ala Ser Leu Ser His Gln Tyr Tyr 
    50                  55                  60


Glu Lys Asp Gly Gln Leu Phe Cys Lys Lys Asp Tyr Trp Ala Arg Tyr 
65                  70                  75                  80


Gly Glu Ser Cys His Gly Cys Ser Glu Gln Ile Thr Lys Gly Leu Val 
                85                  90                  95


Met Val Ala Gly Glu Leu Lys Tyr His Pro Glu Cys Phe Ile Cys Leu 
            100                 105                 110


Thr Cys Gly Thr Phe Ile Gly Asp Gly Asp Thr Tyr Thr Leu Val Glu 
        115                 120                 125


His Ser Lys Leu Tyr Cys Gly His Cys Tyr Tyr Gln Thr Val Val Thr 
    130                 135                 140


Pro Val Ile Glu Gln Ile Leu Pro Asp Ser Pro Gly Ser His Leu Pro 
145                 150                 155                 160


His Thr Val Thr Leu Val Ser Ile Pro Ala Ser Ser His Gly Lys Arg 
                165                 170                 175


Gly Leu Ser Val Ser Ile Asp Pro Pro His Gly Pro Pro Gly Cys Gly 
            180                 185                 190


Thr Glu His Ser His Thr Val Arg Val Gln Gly Val Asp Pro Gly Cys 
        195                 200                 205


Met Ser Pro Asp Val Lys Asn Ser Ile His Val Gly Asp Arg Ile Leu 
    210                 215                 220


Glu Ile Asn Gly Thr Pro Ile Arg Asn Val Pro Leu Asp Glu Ile Asp 
225                 230                 235                 240


Leu Leu Ile Gln Glu Thr Ser Arg Leu Leu Gln Leu Thr Leu Glu His 
                245                 250                 255


Asp Pro His Asp Thr Leu Gly His Gly Leu Gly Pro Glu Thr Ser Pro 
            260                 265                 270


Leu Ser Ser Pro Ala Tyr Thr Pro Ser Gly Glu Ala Gly Ser Ser Ala 
        275                 280                 285


Arg Gln Lys Pro Val Leu Arg Ser Cys Ser Ile Asp Arg Ser Pro Gly 
    290                 295                 300


Ala Gly Ser Leu Gly Ser Pro Ala Ser Gln Arg Lys Asp Leu Gly Arg 
305                 310                 315                 320


Ser Glu Ser Leu Arg Val Val Cys Arg Pro His Arg Ile Phe Arg Pro 
                325                 330                 335


Ser Asp Leu Ile His Gly Glu Val Leu Gly Lys Gly Cys Phe Gly Gln 
            340                 345                 350


Ala Ile Lys Val Thr His Arg Glu Thr Gly Glu Val Met Val Met Lys 
        355                 360                 365


Glu Leu Ile Arg Phe Asp Glu Glu Thr Gln Arg Thr Phe Leu Lys Glu 
    370                 375                 380


Val Lys Val Met Arg Cys Leu Glu His Pro Asn Val Leu Lys Phe Ile 
385                 390                 395                 400


Gly Val Leu Tyr Lys Asp Lys Arg Leu Asn Phe Ile Thr Glu Tyr Ile 
                405                 410                 415


Lys Gly Gly Thr Leu Arg Gly Ile Ile Lys Ser Met Asp Ser Gln Tyr 
            420                 425                 430


Pro Trp Ser Gln Arg Val Ser Phe Ala Lys Asp Ile Ala Ser Gly Met 
        435                 440                 445


Ala Tyr Leu His Ser Met Asn Ile Ile His Arg Asp Leu Asn Ser His 
    450                 455                 460


Asn Cys Leu Val Arg Glu Asn Lys Asn Val Val Val Ala Asp Phe Gly 
465                 470                 475                 480


Leu Ala Arg Leu Met Val Asp Glu Lys Thr Gln Pro Glu Gly Leu Arg 
                485                 490                 495


Ser Leu Lys Lys Pro Asp Arg Lys Lys Arg Tyr Thr Val Val Gly Asn 
            500                 505                 510


Pro Tyr Trp Met Ala Pro Glu Met Ile Asn Gly Arg Ser Tyr Asp Glu 
        515                 520                 525


Lys Val Asp Val Phe Ser Phe Gly Ile Val Leu Cys Glu Ile Ile Gly 
    530                 535                 540


Arg Val Asn Ala Asp Pro Asp Tyr Leu Pro Arg Thr Met Asp Phe Gly 
545                 550                 555                 560


Leu Asn Val Arg Gly Phe Leu Asp Arg Tyr Cys Pro Pro Asn Cys Pro 
                565                 570                 575


Pro Ser Phe Phe Pro Ile Thr Val Arg Cys Cys Asp Leu Asp Pro Glu 
            580                 585                 590


Lys Arg Pro Ser Phe Val Lys Leu Glu His Trp Leu Glu Thr Leu Arg 
        595                 600                 605


Met His Leu Ala Gly His Leu Pro Leu Gly Pro Gln Leu Glu Gln Leu 
    610                 615                 620


Asp Arg Gly Phe Trp Glu Thr Tyr Arg Arg Gly Glu Ser Gly Leu Pro 
625                 630                 635                 640


Ala His Pro Glu Val Pro Asp 
                645


<210>  3908
<211>  391
<212>  DNA
<213>  Homo sapiens

<400>  3908
ggcacgccca tccgaaatgt gcccctggac gagattgacc tgctgattca ggaaaccagc     60

cgcctgctcc agctgaccct cgagcatgac cctcacgata cactgggcca cgggctgggg    120

cctgagacca gccccctgag ctctccggct tatactccca gcggggaggc gggcagctct    180

gcccggcaga aacctgtctt gtaagtcagc ctgctcctcg gttcagctgg gtgctttcac    240

tcctgctggg gctcaggggc tgtgggacct aggtcgggga gccagccctg cacaaatgca    300

gcccaggctt gagccaggga ggtggaggct gcagtaagct gtcatcacac cactgctctc    360

cagcttgggt gacaaaacaa gacccactct c                                   391


<210>  3909
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  3909

Gly Thr Pro Ile Arg Asn Val Pro Leu Asp Glu Ile Asp Leu Leu Ile 
1               5                   10                  15


Gln Glu Thr Ser Arg Leu Leu Gln Leu Thr Leu Glu His Asp Pro His 
            20                  25                  30


Asp Thr Leu Gly His Gly Leu Gly Pro Glu Thr Ser Pro Leu Ser Ser 
        35                  40                  45


Pro Ala Tyr Thr Pro Ser Gly Glu Ala Gly Ser Ser Ala Arg Gln Lys 
    50                  55                  60


Pro Val Leu 
65


<210>  3910
<211>  1353
<212>  DNA
<213>  Homo sapiens

<400>  3910
gggtcgctct gagtccctcc gcgtagtctg ccggccacac cgcatcttcc ggccgtcgga     60

cctcatccac ggggaggtgc tgggcaaggg ctgcttcggc caggctatca aggtgacaca    120

ccgtgagaca ggtgaggtga tggtgatgaa ggagctgatc cggttcgacg aggagaccca    180

gaggacgttc ctcaaggagg tgaaggtcat gcgatgcctg gaacacccca acgtgctcaa    240

gttcatcggg gtgctctaca aggacaagag gctcaacttc atcactgagt acatcaaggg    300

cggcacgctc cggggcatca tcaagagcat ggtgagtcct gggcagagcc agccaccccc    360

gctgtgcggc cccgggcaaa gcagctccct ctgtgagcct cagtctcatc tcttcaatgg    420

ggggaagcca caggggtctc aaaggccctc tgaaccctga ttcctaatca aaaaggggag    480

cgactgactc catctaaagc taggaaaggc caggtacaat ggtgcacacc tgttattctg    540

gcactttggg agcccaaggc aagaggatca ctcgaggcca ggaattcaag gctgcagtga    600

gctgtgatct caccactgca ctccagcctg gaccacacag caagaccctg tctcaaaaac    660

taaaataaaa ttcagagctt tccttaagga tttgaataaa attacaaatc catctttaga    720

aataaagtgc tcaggccagg tgcagtggct catgcctata atctcagcac tttcagaggc    780

tgaggccagc agatcacctg aggtcaggag tccaagacca gcctggccaa catggtgaaa    840

ccccgtctct actaaaaata caaaaattag ctgggcctgg tggcaggcac ctgtaatccc    900

agcactttgg gagactgagg ttggcagatc acctgaggtc aggagttcga gaccatcctg    960

gtaacccgtc tctactaaaa atacaaaaaa ttagccgggc aaggtggcag gtgcctgtag   1020

tcccagctac tcgggagact gaagcaggag aatggcgttg aacccagggg gcagagcctg   1080

cagtgagcca agatcgcacc actgcactct agcctgggtg acagcgagat tccttctcaa   1140

aaaaaaagca cttggaggaa gcctcacaga gccctgtgct ggaccacacc ctggggatcc   1200

agtcctggcc tccagcccca tttctgtacc accctgagac catgggatct tcctcaggtt   1260

ggattacctt gtatccaagg tgtggaccct atgggctcct gctaggtgta acttgacaca   1320

acgggttccg ttgtcaggtg caatttagaa act                                1353


<210>  3911
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  3911

Met Val Met Lys Glu Leu Ile Arg Phe Asp Glu Glu Thr Gln Arg Thr 
1               5                   10                  15


Phe Leu Lys Glu Val Lys Val Met Arg Cys Leu Glu His Pro Asn Val 
            20                  25                  30


Leu Lys Phe Ile Gly Val Leu Tyr Lys Asp Lys Arg Leu Asn Phe Ile 
        35                  40                  45


Thr Glu Tyr Ile Lys Gly Gly Thr Leu Arg Gly Ile Ile Lys Ser Met 
    50                  55                  60


Val Ser Pro Gly Gln Ser Gln Pro Pro Pro Leu Cys Gly Pro Gly Gln 
65                  70                  75                  80


Ser Ser Ser Leu Cys Glu Pro Gln Ser His Leu Phe Asn Gly Gly Lys 
                85                  90                  95


Pro Gln Gly Ser Gln Arg Pro Ser Glu Pro 
            100                 105


<210>  3912
<211>  455
<212>  DNA
<213>  Homo sapiens

<400>  3912
caaaaaccaa cacgttgtcg ttggcgggag gcagtggaag ggatccgccc cgcaagcaag     60

accccgggag cccagccgcc gccgccccgt ctccgagcgc gccatttcca ggccccggcc    120

ctccaggcgc cgctcctagg cctccgcggg cccccgcctc ccgccgcccc ggctgagcgc    180

aggacggccg ccaccctgac ggccccgact ccgccggtcc cgcagccccc gacggggccc    240

gcgcacgccc gcctcaccct ctgccgccgc cgaagctgct gtaggcccga tcgtcgtagg    300

tgtcgaagtc cgccatttgc cgtctccgct ccgagaggaa ccagggatga agttgaagtt    360

actttctctg cctaagatcc agacatcccc cctcaacaag gaaaacaatt gttttttttt    420

cttctccttt ctataaaatc aagaatggaa ccaca                               455


<210>  3913
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  3913

Gln Lys Pro Thr Arg Cys Arg Trp Arg Glu Ala Val Glu Gly Ile Arg 
1               5                   10                  15


Pro Ala Ser Lys Thr Pro Gly Ala Gln Pro Pro Pro Pro Arg Leu Arg 
            20                  25                  30


Ala Arg His Phe Gln Ala Pro Ala Leu Gln Ala Pro Leu Leu Gly Leu 
        35                  40                  45


Arg Gly Pro Pro Pro Pro Ala Ala Pro Ala Glu Arg Arg Thr Ala Ala 
    50                  55                  60


Thr Leu Thr Ala Pro Thr Pro Pro Val Pro Gln Pro Pro Thr Gly Pro 
65                  70                  75                  80


Ala His Ala Arg Leu Thr Leu Cys Arg Arg Arg Ser Cys Cys Arg Pro 
                85                  90                  95


Asp Arg Arg Arg Cys Arg Ser Pro Pro Phe Ala Val Ser Ala Pro Arg 
            100                 105                 110


Gly Thr Arg Asp Glu Val Glu Val Thr Phe Ser Ala 
        115                 120


<210>  3914
<211>  2499
<212>  DNA
<213>  Homo sapiens

<400>  3914
cggcgcggcg gacagccccg gcggcggggc ggggggagtt atattgcggg gtccttcctc     60

gctcaccctg gttcctctcg gagcggagac ggcaaatggc ggacttcgac acctacgacg    120

atcgggccta cagcagcttc ggcggcggca gagggtcccg cggcagtgct ggtggccatg    180

gttcccgtag ccagaaggag ttgcccacag agccccccta cacagcatac gtaggaaatc    240

tacctttcaa tacggttcag ggcgacatag atgctatctt taaggatctc agcataagga    300

gtgtacggct agtcagagac aaagacacag ataaatttaa aggattctgc tatgtagaat    360

tcgatgaagt ggattccctt aaggaagcct tgacatacga tggtgcactg ttgggcgatc    420

ggtcacttcg tgtggacatt gcagaaggca gaaaacaaga taaaggtggc tttggattca    480

gaaaaggtgg accagatgac agagccgctt cagagatggc cctcccctcc gtggatccaa    540

catggatttc agagaaccca cagaagagga aagagcacag agaccacgac tccagcttaa    600

acctcgaaca gtcgcgacgc ccctcaatca agtagccaat cccaactctg ctatcttcgg    660

gggtgccagg cctagagagg aagtcgttca aaaggagcaa gaatgagcct gcggttggga    720

gggaatgggg cgtggggggt tagagcagga ccacagcctg gtgagtcccc gggcagccgt    780

cctgcagccg ccactcctgc gcctgccatt ggcctcctca cagcggaaac acagcttgtg    840

agtgcatgtc agctgttaac aagtggtttt tagtacattc tgggctttgc tgtatctatc    900

tagtgcctgt ttgtgcgttt ttttctttct tccgctgctt ccccattttc cttctgtcct    960

ttttctcctg ctccttgttt tcccagcagc acatggggtt cctcggagga gcagaggtgg   1020

ccgccgtggg ggggcgtttg ggctgcggtg ctgcgtcatt tttcctttgc tttctcttta   1080

ctttagacac tggcccaact ccaggcgttt cctttcattc cctcagtgct tctcttctga   1140

cctgcatgtt gagttctgta ttgctggggc ttccaacaaa aaccagagtc actgacagag   1200

ggaacagcag agaccttgtt ggtattcagc tgtgatggat atagagaatc agaggcacct   1260

tgttttcaca actaggataa aaatatctgc agggtccttt ccattcctat ttagagggag   1320

tcctggctcc atgaccccct cccgagtgga ctgtccaagc agataggctc acacgagaaa   1380

cagtgaggct gaaagggggg gctatggaag agcggtaggg agtccacgga gaagatgcag   1440

tgaatgcttg catgcattca cacgtgtgtg tgtcccagct agttcactcc tttcgccgtg   1500

cgtggtggag gctggcctct ctggctgggt gcagtgaatg gccagcgggt ttcttttctg   1560

ctgggccaag gcgctttggg ggtggagggg gtggtgctgg tgctgcactg ggctgactgc   1620

ggcgctgacg cagcgtttcc ccccatccct gttgcctgtg tgttgtgtgg atctgttcct   1680

agtataggca acataatgag atactgtgct tcccacctcc ccttcagttc agagccaaaa   1740

tgggtctaga atctggcact ttactcattt cctttgataa attgtactat gcagagctgt   1800

caggaacctt cagatagcag tagaggactg cagctgtcta ggtctgcggc cacatcttgg   1860

ggacacactg gactgttccc atgtgcaggg ttcagcagtt atgtgggagt gctaggggtt   1920

aggcttttga gcttgaacgc ctgcgtgtga acagatgaaa aatccttcag tacccaagtc   1980

ccagtctgtc ctatggggag cagtttgggg gcggccggca gcaggagcct gggaaagagg   2040

ccctcgccag gtgatggcag ggccagggtg gcctggggca cccagcggaa tgtgcttagt   2100

atttggtcac cagccgtcat cctgggcttt tcctactgtg tcttgttaca aggcctcagc   2160

aatccacaga actctctctc cttccttcca cctgtcagct tctctgcttc tgagataaga   2220

accatttgtg taacaccaac acttaacttc agaaagacat gcattatgtg gtgtaatcaa   2280

acccgatgct ttcagatgac ctacttacat cttcaatgtg gataagataa agaacaaaac   2340

acatgcatct aaactgctgg gcaatccagt tgacttttaa atgtaagaat ggaattccaa   2400

acacttaaca cattcagcta tatgacagaa agtaaatcta tggatatggt attttgtgaa   2460

tgatctttta aataaaagaa aaccttacgt aatatttaa                          2499


<210>  3915
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  3915

Met Ala Asp Phe Asp Thr Tyr Asp Asp Arg Ala Tyr Ser Ser Phe Gly 
1               5                   10                  15


Gly Gly Arg Gly Ser Arg Gly Ser Ala Gly Gly His Gly Ser Arg Ser 
            20                  25                  30


Gln Lys Glu Leu Pro Thr Glu Pro Pro Tyr Thr Ala Tyr Val Gly Asn 
        35                  40                  45


Leu Pro Phe Asn Thr Val Gln Gly Asp Ile Asp Ala Ile Phe Lys Asp 
    50                  55                  60


Leu Ser Ile Arg Ser Val Arg Leu Val Arg Asp Lys Asp Thr Asp Lys 
65                  70                  75                  80


Phe Lys Gly Phe Cys Tyr Val Glu Phe Asp Glu Val Asp Ser Leu Lys 
                85                  90                  95


Glu Ala Leu Thr Tyr Asp Gly Ala Leu Leu Gly Asp Arg Ser Leu Arg 
            100                 105                 110


Val Asp Ile Ala Glu Gly Arg Lys Gln Asp Lys Gly Gly Phe Gly Phe 
        115                 120                 125


Arg Lys Gly Gly Pro Asp Asp Arg Ala Ala Ser Glu Met Ala Leu Pro 
    130                 135                 140


Ser Val Asp Pro Thr Trp Ile Ser Glu Asn Pro Gln Lys Arg Lys Glu 
145                 150                 155                 160


His Arg Asp His Asp Ser Ser Leu Asn Leu Glu Gln Ser Arg Arg Pro 
                165                 170                 175


Ser Ile Lys 



<210>  3916
<211>  2508
<212>  DNA
<213>  Homo sapiens

<400>  3916
ctggttcctc tcggagcgga gacggcaaat ggcggacttc gacacctacg acgatcgggc     60

ctacagcagc ttcggcggcg gcagagggtc ccgcggcagt gctggtggcc atggttcccg    120

tagccagaag gagttgccca cagagccccc ctacacagca tacgtaggaa atctaccttt    180

caatacggtt cagggcgaca tagatgctat ctttaaggat ctcagcataa ggagtgtacg    240

gctagtcaga gacaaagaca cagataaatt taaaggattc tgctatgtag aattcgatga    300

agtggattcc cttaaggaag ccttgacata cgatggtgca ctgttgggcg atcggtcact    360

tcgtgtggac attgcagaag gcagaaaaca agataaaggt ggctttggat tcagaaaagg    420

tggaccagat gacagaggct tcagggatga cttcttaggg ggcaggggag gtagtcgccc    480

aggcgaccgg cgaacaggcc cccccatggg cagccgcttc agagatggcc ctcccctccg    540

tggatccaac atggatttca gagaacccac agaagaggaa agagcacaga gaccacgact    600

ccagcttaaa cctcgaacag tcgcgacgcc cctcaatcaa gtagccaatc ccaactctgc    660

tatcttcggg ggtgccaggc ctagagagga agtcgttcaa aaggagcaag aatgagcctg    720

cggttgggag ggaatggggc gtggggggtt agagcaggac cacagcctgg tgagtccccg    780

ggcagccgtc ctgcagccgc cactcctgcg cctgccattg gcctcctcac agcggaaaca    840

cagcttgtga gtgcatgtca gctgttaaca agtggttttt agtacattct gggctttgct    900

gtatctatct agtgcctgtt tgtgcgtttt tttctttctt ccgctgcttc cccattttcc    960

ttctgtcctt tttctcctgc tccttgtttt cccagcagca catggggttc ctcggaggag   1020

cagaggtggc cgccgtgggg gggcgtttgg gctgcggtgc tgcgtcattt ttcctttgct   1080

ttctctttac tttagacact ggcccaactc caggcgtttc ctttcattcc ctcagtgctt   1140

ctcttctgac ctgcatgttg agttctgtat tgctggggct tccaacaaaa accagagtca   1200

ctgacagagg gaacagcaga gaccttgttg gtattcagct gtgatggata tagagaatca   1260

gaggcacctt gttttcacaa ctaggataaa aatatctgca gggtcctttc cattcctatt   1320

tagagggagt cctggctcca tgaccccctc ccgagtggac tgtccaagca gataggctca   1380

cacgagaaac agtgaggctg aaaggggggg ctatggaaga gcggtaggga gtccacggag   1440

aagatgcagt gaatgcttgc atgcattcac acgtgtgtgt gtcccagcta gttcactcct   1500

ttcgccgtgc gtggtggagg ctggcctctc tggctgggtg cagtgaatgg ccagcgggtt   1560

tcttttctgc tgggccaagg cgctttgggg gtggaggggg tggtgctggt gctgcactgg   1620

gctgactgcg gcgctgacgc agcgtttccc cccatccctg ttgcctgtgt gttgtgtgga   1680

tctgttccta gtataggcaa cataatgaga tactgtgctt cccacctccc cttcagttca   1740

gagccaaaat gggtctagaa tctggcactt tactcatttc ctttgataaa ttgtactatg   1800

cagagctgtc aggaaccttc agatagcagt agaggactgc agctgtctag gtctgcggcc   1860

acatcttggg gacacactgg actgttccca tgtgcagggt tcagcagtta tgtgggagtg   1920

ctaggggtta ggcttttgag cttgaacgcc tgcgtgtgaa cagatgaaaa atccttcagt   1980

acccaagtcc cagtctgtcc tatggggagc agtttggggg cggccggcag caggagcctg   2040

ggaaagaggc cctcgccagg tgatggcagg gccagggtgg cctggggcac ccagcggaat   2100

gtgcttagta tttggtcacc agccgtcatc ctgggctttt cctactgtgt cttgttacaa   2160

ggcctcagca atccacagaa ctctctctcc ttccttccac ctgtcagctt ctctgcttct   2220

gagataagaa ccatttgtgt aacaccaaca cttaacttca gaaagacatg cattatgtgg   2280

tgtaatcaaa cccgatgctt tcagatgacc tacttacatc ttcaatgtgg ataagataaa   2340

gaacaaaaca catgcatcta aactgctggg caatccagtt gacttttaaa tgtaagaatg   2400

gaattccaaa cacttaacac attcagctat atgacagaaa gtaaatctat ggatatggta   2460

ttttgtgaat gatcttttaa ataaaagaaa accttacgta atatttaa                2508


<210>  3917
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  3917

Met Ala Asp Phe Asp Thr Tyr Asp Asp Arg Ala Tyr Ser Ser Phe Gly 
1               5                   10                  15


Gly Gly Arg Gly Ser Arg Gly Ser Ala Gly Gly His Gly Ser Arg Ser 
            20                  25                  30


Gln Lys Glu Leu Pro Thr Glu Pro Pro Tyr Thr Ala Tyr Val Gly Asn 
        35                  40                  45


Leu Pro Phe Asn Thr Val Gln Gly Asp Ile Asp Ala Ile Phe Lys Asp 
    50                  55                  60


Leu Ser Ile Arg Ser Val Arg Leu Val Arg Asp Lys Asp Thr Asp Lys 
65                  70                  75                  80


Phe Lys Gly Phe Cys Tyr Val Glu Phe Asp Glu Val Asp Ser Leu Lys 
                85                  90                  95


Glu Ala Leu Thr Tyr Asp Gly Ala Leu Leu Gly Asp Arg Ser Leu Arg 
            100                 105                 110


Val Asp Ile Ala Glu Gly Arg Lys Gln Asp Lys Gly Gly Phe Gly Phe 
        115                 120                 125


Arg Lys Gly Gly Pro Asp Asp Arg Gly Phe Arg Asp Asp Phe Leu Gly 
    130                 135                 140


Gly Arg Gly Gly Ser Arg Pro Gly Asp Arg Arg Thr Gly Pro Pro Met 
145                 150                 155                 160


Gly Ser Arg Phe Arg Asp Gly Pro Pro Leu Arg Gly Ser Asn Met Asp 
                165                 170                 175


Phe Arg Glu Pro Thr Glu Glu Glu Arg Ala Gln Arg Pro Arg Leu Gln 
            180                 185                 190


Leu Lys Pro Arg Thr Val Ala Thr Pro Leu Asn Gln Val Ala Asn Pro 
        195                 200                 205


Asn Ser Ala Ile Phe Gly Gly Ala Arg Pro Arg Glu Glu Val Val Gln 
    210                 215                 220


Lys Glu Gln Glu 
225


<210>  3918
<211>  559
<212>  DNA
<213>  Homo sapiens

<400>  3918
tcctctcgga gcggagacgg caaatggcgg acttcgacac ctacgacgat cgggcctaca     60

gcagcttcgg cggcggcaga gggtcccgcg gcagtgctgg tggccatggt tcccgtagcc    120

agaaggagtt gcccacagag cccccctaca cagcatacgt aggaaatcta cctttcaata    180

cggttcaggg cgacatagat gctatcttta aggatctcac aatccacaga actctctctc    240

cttccttcca cctgtcagct tctctgcttc tgagataaga accatttgtg taacaccaac    300

acttaacttc agaaagacat gcattatgtg gtgtaatcaa acccgatgct ttcagatgac    360

ctacttacat cttcaatgtg gataagataa agaacaaaac acatgcatct aaactgctgg    420

gcaatccagt tgacttttaa atgtaagaat ggaattccaa acacttaaca cattcagcta    480

tatgacagaa agtaaatcta tggatatggt attttgtgaa tgatctttta aataaaagaa    540

aaccttacgt aatatttaa                                                 559


<210>  3919
<211>  84
<212>  PRT
<213>  Homo sapiens

<400>  3919

Met Ala Asp Phe Asp Thr Tyr Asp Asp Arg Ala Tyr Ser Ser Phe Gly 
1               5                   10                  15


Gly Gly Arg Gly Ser Arg Gly Ser Ala Gly Gly His Gly Ser Arg Ser 
            20                  25                  30


Gln Lys Glu Leu Pro Thr Glu Pro Pro Tyr Thr Ala Tyr Val Gly Asn 
        35                  40                  45


Leu Pro Phe Asn Thr Val Gln Gly Asp Ile Asp Ala Ile Phe Lys Asp 
    50                  55                  60


Leu Thr Ile His Arg Thr Leu Ser Pro Ser Phe His Leu Ser Ala Ser 
65                  70                  75                  80


Leu Leu Leu Arg 



<210>  3920
<211>  519
<212>  DNA
<213>  Homo sapiens

<400>  3920
cctctcggag cggagacggc aaatggcgga cttcgacacc tacgacgatc gggcctacag     60

cagcttcggc ggcggcagag ggtcccgcgg cagtgctggt ggccatggtt cccgtagcca    120

gaaggagttg cccacagagc ccccctacac agcatacgta ggaaatctac ctttcaatac    180

ggttcagggc gacatagatg ctatctttaa ggatctcact tctctgcttc tgagataaga    240

accatttgtg taacaccaac acttaacttc agaaagacat gcattatgtg gtgtaatcaa    300

acccgatgct ttcagatgac ctacttacat cttcaatgtg gataagataa agaacaaaac    360

acatgcatct aaactgctgg gcaatccagt tgacttttaa atgtaagaat ggaattccaa    420

acacttaaca cattcagcta tatgacagaa agtaaatcta tggatatggt attttgtgaa    480

tgatctttta aataaaagaa aaccttacgt aatatttaa                           519


<210>  3921
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  3921

Met Ala Asp Phe Asp Thr Tyr Asp Asp Arg Ala Tyr Ser Ser Phe Gly 
1               5                   10                  15


Gly Gly Arg Gly Ser Arg Gly Ser Ala Gly Gly His Gly Ser Arg Ser 
            20                  25                  30


Gln Lys Glu Leu Pro Thr Glu Pro Pro Tyr Thr Ala Tyr Val Gly Asn 
        35                  40                  45


Leu Pro Phe Asn Thr Val Gln Gly Asp Ile Asp Ala Ile Phe Lys Asp 
    50                  55                  60


Leu Thr Ser Leu Leu Leu Arg 
65                  70


<210>  3922
<211>  2560
<212>  DNA
<213>  Homo sapiens

<400>  3922
tctcggagcg gagacggcaa atggcggact tcgacaccta cgacgatcgg gcctacagca     60

gcttcggcgg cggcagaggg tcccgcggca gtgctggtgg ccatggttcc cgtagccaga    120

aggagttgcc cacagagccc ccctacacag catacgtagg aaatctacct ttcaatacgg    180

ttcagggcga catagatgct atctttaagg atctcagcat aaggagtgta cggctagtca    240

gagacaaaga cacagataaa tttaaaggat tctgctatgt agaattcgat gaagtggatt    300

cccttaagga agccttgaca tacgatggtg cactgttggg cgatcggtca cttcgtgtgg    360

acattgcaga aggcagaaaa caagataaag gtggctttgg attcagaaaa ggtggaccag    420

atgacagagg aatgggtagc tctcgagaat ctagaggtgg atgggattcc cgggatgact    480

tcaattctgg cttcagggat gacttcttag ggggcagggg aggtagtcgc ccaggcgacc    540

ggcgaacagg cccccccatg ggcagccgct tcagagatgg ccctcccctc cgtggatcca    600

acatggattt cagagaaccc acagaagagg aaagagcaca gagaccacga ctccagctta    660

aacctcgaac agtcgcgacg cccctcaatc aagtagccaa tcccaactct gctatcttcg    720

ggggtgccag gcctagagag gaagtcgttc aaaaggagca agaatgagcc tgcggttggg    780

agggaatggg gcgtgggggg ttagagcagg accacagcct ggtgagtccc cgggcagccg    840

tcctgcagcc gccactcctg cgcctgccat tggcctcctc acagcggaaa cacagcttgt    900

gagtgcatgt cagctgttaa caagtggttt ttagtacatt ctgggctttg ctgtatctat    960

ctagtgcctg tttgtgcgtt tttttctttc ttccgctgct tccccatttt ccttctgtcc   1020

tttttctcct gctccttgtt ttcccagcag cacatggggt tcctcggagg agcagaggtg   1080

gccgccgtgg gggggcgttt gggctgcggt gctgcgtcat ttttcctttg ctttctcttt   1140

actttagaca ctggcccaac tccaggcgtt tcctttcatt ccctcagtgc ttctcttctg   1200

acctgcatgt tgagttctgt attgctgggg cttccaacaa aaaccagagt cactgacaga   1260

gggaacagca gagaccttgt tggtattcag ctgtgatgga tatagagaat cagaggcacc   1320

ttgttttcac aactaggata aaaatatctg cagggtcctt tccattccta tttagaggga   1380

gtcctggctc catgaccccc tcccgagtgg actgtccaag cagataggct cacacgagaa   1440

acagtgaggc tgaaaggggg ggctatggaa gagcggtagg gagtccacgg agaagatgca   1500

gtgaatgctt gcatgcattc acacgtgtgt gtgtcccagc tagttcactc ctttcgccgt   1560

gcgtggtgga ggctggcctc tctggctggg tgcagtgaat ggccagcggg tttcttttct   1620

gctgggccaa ggcgctttgg gggtggaggg ggtggtgctg gtgctgcact gggctgactg   1680

cggcgctgac gcagcgtttc cccccatccc tgttgcctgt gtgttgtgtg gatctgttcc   1740

tagtataggc aacataatga gatactgtgc ttcccacctc cccttcagtt cagagccaaa   1800

atgggtctag aatctggcac tttactcatt tcctttgata aattgtacta tgcagagctg   1860

tcaggaacct tcagatagca gtagaggact gcagctgtct aggtctgcgg ccacatcttg   1920

gggacacact ggactgttcc catgtgcagg gttcagcagt tatgtgggag tgctaggggt   1980

taggcttttg agcttgaacg cctgcgtgtg aacagatgaa aaatccttca gtacccaagt   2040

cccagtctgt cctatgggga gcagtttggg ggcggccggc agcaggagcc tgggaaagag   2100

gccctcgcca ggtgatggca gggccagggt ggcctggggc acccagcgga atgtgcttag   2160

tatttggtca ccagccgtca tcctgggctt ttcctactgt gtcttgttac aaggcctcag   2220

caatccacag aactctctct ccttccttcc acctgtcagc ttctctgctt ctgagataag   2280

aaccatttgt gtaacaccaa cacttaactt cagaaagaca tgcattatgt ggtgtaatca   2340

aacccgatgc tttcagatga cctacttaca tcttcaatgt ggataagata aagaacaaaa   2400

cacatgcatc taaactgctg ggcaatccag ttgactttta aatgtaagaa tggaattcca   2460

aacacttaac acattcagct atatgacaga aagtaaatct atggatatgg tattttgtga   2520

atgatctttt aaataaaaga aaaccttacg taatatttaa                         2560


<210>  3923
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  3923

Met Ala Asp Phe Asp Thr Tyr Asp Asp Arg Ala Tyr Ser Ser Phe Gly 
1               5                   10                  15


Gly Gly Arg Gly Ser Arg Gly Ser Ala Gly Gly His Gly Ser Arg Ser 
            20                  25                  30


Gln Lys Glu Leu Pro Thr Glu Pro Pro Tyr Thr Ala Tyr Val Gly Asn 
        35                  40                  45


Leu Pro Phe Asn Thr Val Gln Gly Asp Ile Asp Ala Ile Phe Lys Asp 
    50                  55                  60


Leu Ser Ile Arg Ser Val Arg Leu Val Arg Asp Lys Asp Thr Asp Lys 
65                  70                  75                  80


Phe Lys Gly Phe Cys Tyr Val Glu Phe Asp Glu Val Asp Ser Leu Lys 
                85                  90                  95


Glu Ala Leu Thr Tyr Asp Gly Ala Leu Leu Gly Asp Arg Ser Leu Arg 
            100                 105                 110


Val Asp Ile Ala Glu Gly Arg Lys Gln Asp Lys Gly Gly Phe Gly Phe 
        115                 120                 125


Arg Lys Gly Gly Pro Asp Asp Arg Gly Met Gly Ser Ser Arg Glu Ser 
    130                 135                 140


Arg Gly Gly Trp Asp Ser Arg Asp Asp Phe Asn Ser Gly Phe Arg Asp 
145                 150                 155                 160


Asp Phe Leu Gly Gly Arg Gly Gly Ser Arg Pro Gly Asp Arg Arg Thr 
                165                 170                 175


Gly Pro Pro Met Gly Ser Arg Phe Arg Asp Gly Pro Pro Leu Arg Gly 
            180                 185                 190


Ser Asn Met Asp Phe Arg Glu Pro Thr Glu Glu Glu Arg Ala Gln Arg 
        195                 200                 205


Pro Arg Leu Gln Leu Lys Pro Arg Thr Val Ala Thr Pro Leu Asn Gln 
    210                 215                 220


Val Ala Asn Pro Asn Ser Ala Ile Phe Gly Gly Ala Arg Pro Arg Glu 
225                 230                 235                 240


Glu Val Val Gln Lys Glu Gln Glu 
                245


<210>  3924
<211>  1920
<212>  DNA
<213>  Homo sapiens

<400>  3924
tctcggagcg gagacggcaa atggcggact tcgacaccta cgacgatcgg gcctacagca     60

gcttcggcgg cggcagaggg tcccgcggca gtgctggtgg ccatggttcc cgtagccaga    120

aggagttgcc cacagagccc ccctacacag catacgtagg aaatctacct ttcaatacgg    180

ttcagggcga catagatgct atctttaagg atctcagcat aaggagtgta cggctagtca    240

gagacaaaga cacagataaa tttaaaggat tctgctatgt agaattcgat gaagtggatt    300

cccttaagga agccttgaca tacgatggtg cactgttggg cgatcggtca cttcgtgtgg    360

acattgcaga aggcagaaaa caagataaag gtggctttgg attcagaaaa ggtggaccag    420

atgacagagg agcagaggtg gccgccgtgg gggggcgttt gggctgcggt gctgcgtcat    480

ttttcctttg ctttctcttt actttagaca ctggcccaac tccaggcgtt tcctttcatt    540

ccctcagtgc ttctcttctg acctgcatgt tgagttctgt attgctgggg cttccaacaa    600

aaaccagagt cactgacaga gggaacagca gagaccttgt tggtattcag ctgtgatgga    660

tatagagaat cagaggcacc ttgttttcac aactaggata aaaatatctg cagggtcctt    720

tccattccta tttagaggga gtcctggctc catgaccccc tcccgagtgg actgtccaag    780

cagataggct cacacgagaa acagtgaggc tgaaaggggg ggctatggaa gagcggtagg    840

gagtccacgg agaagatgca gtgaatgctt gcatgcattc acacgtgtgt gtgtcccagc    900

tagttcactc ctttcgccgt gcgtggtgga ggctggcctc tctggctggg tgcagtgaat    960

ggccagcggg tttcttttct gctgggccaa ggcgctttgg gggtggaggg ggtggtgctg   1020

gtgctgcact gggctgactg cggcgctgac gcagcgtttc cccccatccc tgttgcctgt   1080

gtgttgtgtg gatctgttcc tagtataggc aacataatga gatactgtgc ttcccacctc   1140

cccttcagtt cagagccaaa atgggtctag aatctggcac tttactcatt tcctttgata   1200

aattgtacta tgcagagctg tcaggaacct tcagatagca gtagaggact gcagctgtct   1260

aggtctgcgg ccacatcttg gggacacact ggactgttcc catgtgcagg gttcagcagt   1320

tatgtgggag tgctaggggt taggcttttg agcttgaacg cctgcgtgtg aacagatgaa   1380

aaatccttca gtacccaagt cccagtctgt cctatgggga gcagtttggg ggcggccggc   1440

agcaggagcc tgggaaagag gccctcgcca ggtgatggca gggccagggt ggcctggggc   1500

acccagcgga atgtgcttag tatttggtca ccagccgtca tcctgggctt ttcctactgt   1560

gtcttgttac aaggcctcag caatccacag aactctctct ccttccttcc acctgtcagc   1620

ttctctgctt ctgagataag aaccatttgt gtaacaccaa cacttaactt cagaaagaca   1680

tgcattatgt ggtgtaatca aacccgatgc tttcagatga cctacttaca tcttcaatgt   1740

ggataagata aagaacaaaa cacatgcatc taaactgctg ggcaatccag ttgactttta   1800

aatgtaagaa tggaattcca aacacttaac acattcagct atatgacaga aagtaaatct   1860

atggatatgg tattttgtga atgatctttt aaataaaaga aaaccttacg taatatttaa   1920


<210>  3925
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  3925

Met Ala Asp Phe Asp Thr Tyr Asp Asp Arg Ala Tyr Ser Ser Phe Gly 
1               5                   10                  15


Gly Gly Arg Gly Ser Arg Gly Ser Ala Gly Gly His Gly Ser Arg Ser 
            20                  25                  30


Gln Lys Glu Leu Pro Thr Glu Pro Pro Tyr Thr Ala Tyr Val Gly Asn 
        35                  40                  45


Leu Pro Phe Asn Thr Val Gln Gly Asp Ile Asp Ala Ile Phe Lys Asp 
    50                  55                  60


Leu Ser Ile Arg Ser Val Arg Leu Val Arg Asp Lys Asp Thr Asp Lys 
65                  70                  75                  80


Phe Lys Gly Phe Cys Tyr Val Glu Phe Asp Glu Val Asp Ser Leu Lys 
                85                  90                  95


Glu Ala Leu Thr Tyr Asp Gly Ala Leu Leu Gly Asp Arg Ser Leu Arg 
            100                 105                 110


Val Asp Ile Ala Glu Gly Arg Lys Gln Asp Lys Gly Gly Phe Gly Phe 
        115                 120                 125


Arg Lys Gly Gly Pro Asp Asp Arg Gly Ala Glu Val Ala Ala Val Gly 
    130                 135                 140


Gly Arg Leu Gly Cys Gly Ala Ala Ser Phe Phe Leu Cys Phe Leu Phe 
145                 150                 155                 160


Thr Leu Asp Thr Gly Pro Thr Pro Gly Val Ser Phe His Ser Leu Ser 
                165                 170                 175


Ala Ser Leu Leu Thr Cys Met Leu Ser Ser Val Leu Leu Gly Leu Pro 
            180                 185                 190


Thr Lys Thr Arg Val Thr Asp Arg Gly Asn Ser Arg Asp Leu Val Gly 
        195                 200                 205


Ile Gln Leu 
    210


<210>  3926
<211>  1919
<212>  DNA
<213>  Homo sapiens

<400>  3926
tctcggagcg gagacggcaa atggcggact tcgacaccta cgacgatcgg gcctacagca     60

gcttcggcgg cggcagaggg tcccgcggca gtgctggtgg ccatggttcc cgtagccaga    120

aggagttgcc cacagagccc ccctacacag catacgtagg aaatctacct ttcaatacgg    180

ttcagggcga catagatgct atctttaagg atctcagcat aaggagtgta cggctagtca    240

gagacaaaga cacagataaa tttaaaggat tctgctatgt agaattcgat gaagtggatt    300

cccttaagga agccttgaca tacgatggtg cactgttggg cgatcggtca cttcgtgtgg    360

acattgcaga aggcagaaaa caagataaag gtggctttgg attcagaaaa ggtggaccag    420

atgacagagg cttcagggat gacttcttag ggggcgtttg ggctgcggtg ctgcgtcatt    480

tttcctttgc tttctcttta ctttagacac tggcccaact ccaggcgttt cctttcattc    540

cctcagtgct tctcttctga cctgcatgtt gagttctgta ttgctggggc ttccaacaaa    600

aaccagagtc actgacagag ggaacagcag agaccttgtt ggtattcagc tgtgatggat    660

atagagaatc agaggcacct tgttttcaca actaggataa aaatatctgc agggtccttt    720

ccattcctat ttagagggag tcctggctcc atgaccccct cccgagtgga ctgtccaagc    780

agataggctc acacgagaaa cagtgaggct gaaagggggg gctatggaag agcggtaggg    840

agtccacgga gaagatgcag tgaatgcttg catgcattca cacgtgtgtg tgtcccagct    900

agttcactcc tttcgccgtg cgtggtggag gctggcctct ctggctgggt gcagtgaatg    960

gccagcgggt ttcttttctg ctgggccaag gcgctttggg ggtggagggg gtggtgctgg   1020

tgctgcactg ggctgactgc ggcgctgacg cagcgtttcc ccccatccct gttgcctgtg   1080

tgttgtgtgg atctgttcct agtataggca acataatgag atactgtgct tcccacctcc   1140

ccttcagttc agagccaaaa tgggtctaga atctggcact ttactcattt cctttgataa   1200

attgtactat gcagagctgt caggaacctt cagatagcag tagaggactg cagctgtcta   1260

ggtctgcggc cacatcttgg ggacacactg gactgttccc atgtgcaggg ttcagcagtt   1320

atgtgggagt gctaggggtt aggcttttga gcttgaacgc ctgcgtgtga acagatgaaa   1380

aatccttcag tacccaagtc ccagtctgtc ctatggggag cagtttgggg gcggccggca   1440

gcaggagcct gggaaagagg ccctcgccag gtgatggcag ggccagggtg gcctggggca   1500

cccagcggaa tgtgcttagt atttggtcac cagccgtcat cctgggcttt tcctactgtg   1560

tcttgttaca aggcctcagc aatccacaga actctctctc cttccttcca cctgtcagct   1620

tctctgcttc tgagataaga accatttgtg taacaccaac acttaacttc agaaagacat   1680

gcattatgtg gtgtaatcaa acccgatgct ttcagatgac ctacttacat cttcaatgtg   1740

gataagataa agaacaaaac acatgcatct aaactgctgg gcaatccagt tgacttttaa   1800

atgtaagaat ggaattccaa acacttaaca cattcagcta tatgacagaa agtaaatcta   1860

tggatatggt attttgtgaa tgatctttta aataaaagaa aaccttacgt aatatttaa    1919


<210>  3927
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  3927

Met Ala Asp Phe Asp Thr Tyr Asp Asp Arg Ala Tyr Ser Ser Phe Gly 
1               5                   10                  15


Gly Gly Arg Gly Ser Arg Gly Ser Ala Gly Gly His Gly Ser Arg Ser 
            20                  25                  30


Gln Lys Glu Leu Pro Thr Glu Pro Pro Tyr Thr Ala Tyr Val Gly Asn 
        35                  40                  45


Leu Pro Phe Asn Thr Val Gln Gly Asp Ile Asp Ala Ile Phe Lys Asp 
    50                  55                  60


Leu Ser Ile Arg Ser Val Arg Leu Val Arg Asp Lys Asp Thr Asp Lys 
65                  70                  75                  80


Phe Lys Gly Phe Cys Tyr Val Glu Phe Asp Glu Val Asp Ser Leu Lys 
                85                  90                  95


Glu Ala Leu Thr Tyr Asp Gly Ala Leu Leu Gly Asp Arg Ser Leu Arg 
            100                 105                 110


Val Asp Ile Ala Glu Gly Arg Lys Gln Asp Lys Gly Gly Phe Gly Phe 
        115                 120                 125


Arg Lys Gly Gly Pro Asp Asp Arg Gly Phe Arg Asp Asp Phe Leu Gly 
    130                 135                 140


Gly Val Trp Ala Ala Val Leu Arg His Phe Ser Phe Ala Phe Ser Leu 
145                 150                 155                 160


Leu 



<210>  3928
<211>  2288
<212>  DNA
<213>  Homo sapiens

<400>  3928
cggacttcga cacctacgac gatcgggcct acagcagctt cggcggcggc agagggattc     60

tgctatgtag aattcgatga agtggattcc cttaaggaag ccttgacata cgatggtgca    120

ctgttgggcg atcggtcact tcgtgtggac attgcagaag gcagaaaaca agataaaggt    180

ggctttggat tcagaaaagg tggaccagat gacagaggct tcagggatga cttcttaggg    240

ggcaggggag gtagtcgccc aggcgaccgg cgaacaggcc cccccatggg cagccgcttc    300

agagatggcc ctcccctccg tggatccaac atggatttca gagaacccac agaagaggaa    360

agagcacaga gaccacgact ccagcttaaa cctcgaacag tcgcgacgcc cctcaatcaa    420

gtagccaatc ccaactctgc tatcttcggg ggtgccaggc ctagagagga agtcgttcaa    480

aaggagcaag aatgagcctg cggttgggag ggaatggggc gtggggggtt agagcaggac    540

cacagcctgg tgagtccccg ggcagccgtc ctgcagccgc cactcctgcg cctgccattg    600

gcctcctcac agcggaaaca cagcttgtga gtgcatgtca gctgttaaca agtggttttt    660

agtacattct gggctttgct gtatctatct agtgcctgtt tgtgcgtttt tttctttctt    720

ccgctgcttc cccattttcc ttctgtcctt tttctcctgc tccttgtttt cccagcagca    780

catggggttc ctcggaggag cagaggtggc cgccgtgggg gggcgtttgg gctgcggtgc    840

tgcgtcattt ttcctttgct ttctctttac tttagacact ggcccaactc caggcgtttc    900

ctttcattcc ctcagtgctt ctcttctgac ctgcatgttg agttctgtat tgctggggct    960

tccaacaaaa accagagtca ctgacagagg gaacagcaga gaccttgttg gtattcagct   1020

gtgatggata tagagaatca gaggcacctt gttttcacaa ctaggataaa aatatctgca   1080

gggtcctttc cattcctatt tagagggagt cctggctcca tgaccccctc ccgagtggac   1140

tgtccaagca gataggctca cacgagaaac agtgaggctg aaaggggggg ctatggaaga   1200

gcggtaggga gtccacggag aagatgcagt gaatgcttgc atgcattcac acgtgtgtgt   1260

gtcccagcta gttcactcct ttcgccgtgc gtggtggagg ctggcctctc tggctgggtg   1320

cagtgaatgg ccagcgggtt tcttttctgc tgggccaagg cgctttgggg gtggaggggg   1380

tggtgctggt gctgcactgg gctgactgcg gcgctgacgc agcgtttccc cccatccctg   1440

ttgcctgtgt gttgtgtgga tctgttccta gtataggcaa cataatgaga tactgtgctt   1500

cccacctccc cttcagttca gagccaaaat gggtctagaa tctggcactt tactcatttc   1560

ctttgataaa ttgtactatg cagagctgtc aggaaccttc agatagcagt agaggactgc   1620

agctgtctag gtctgcggcc acatcttggg gacacactgg actgttccca tgtgcagggt   1680

tcagcagtta tgtgggagtg ctaggggtta ggcttttgag cttgaacgcc tgcgtgtgaa   1740

cagatgaaaa atccttcagt acccaagtcc cagtctgtcc tatggggagc agtttggggg   1800

cggccggcag caggagcctg ggaaagaggc cctcgccagg tgatggcagg gccagggtgg   1860

cctggggcac ccagcggaat gtgcttagta tttggtcacc agccgtcatc ctgggctttt   1920

cctactgtgt cttgttacaa ggcctcagca atccacagaa ctctctctcc ttccttccac   1980

ctgtcagctt ctctgcttct gagataagaa ccatttgtgt aacaccaaca cttaacttca   2040

gaaagacatg cattatgtgg tgtaatcaaa cccgatgctt tcagatgacc tacttacatc   2100

ttcaatgtgg ataagataaa gaacaaaaca catgcatcta aactgctggg caatccagtt   2160

gacttttaaa tgtaagaatg gaattccaaa cacttaacac attcagctat atgacagaaa   2220

gtaaatctat ggatatggta ttttgtgaat gatcttttaa ataaaagaaa accttacgta   2280

atatttaa                                                            2288


<210>  3929
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  3929

Met Gly Ser Arg Phe Arg Asp Gly Pro Pro Leu Arg Gly Ser Asn Met 
1               5                   10                  15


Asp Phe Arg Glu Pro Thr Glu Glu Glu Arg Ala Gln Arg Pro Arg Leu 
            20                  25                  30


Gln Leu Lys Pro Arg Thr Val Ala Thr Pro Leu Asn Gln Val Ala Asn 
        35                  40                  45


Pro Asn Ser Ala Ile Phe Gly Gly Ala Arg Pro Arg Glu Glu Val Val 
    50                  55                  60


Gln Lys Glu Gln Glu 
65


<210>  3930
<211>  1236
<212>  DNA
<213>  Homo sapiens

<400>  3930
cctacgacga tcgggcctac agcagcttcg gcggcggcag agggtcccgc ggcagtgctg     60

gtggccatgg ttcccgtagc cagaaggagt tgcccacaga gcccccctac acagcatacg    120

taggaaatct acctttcaat acggttcagg gcgacataga tgctatcttt aaggatctca    180

gcataaggag tgtacggcta gtcagagaca aagacacaga taaatttaaa ggattctgct    240

atgtagaatt cgatgaagtg gattccctta aggaagcctt gacatacgat ggtgcagtaa    300

ggccaaggcg ctttgggggt ggagggggtg gtgctggtgc tgcactgggc tgactgcggc    360

gctgacgcag cgtttccccc catccctgtt gcctgtgtgt tgtgtggatc tgttcctagt    420

ataggcaaca taatgagata ctgtgcttcc cacctcccct tcagttcaga gccaaaatgg    480

gtctagaatc tggcacttta ctcatttcct ttgataaatt gtactatgca gagctgtcag    540

gaaccttcag atagcagtag aggactgcag ctgtctaggt ctgcggccac atcttgggga    600

cacactggac tgttcccatg tgcagggttc agcagttatg tgggagtgct aggggttagg    660

cttttgagct tgaacgcctg cgtgtgaaca gatgaaaaat ccttcagtac ccaagtccca    720

gtctgtccta tggggagcag tttgggggcg gccggcagca ggagcctggg aaagaggccc    780

tcgccaggtg atggcagggc cagggtggcc tggggcaccc agcggaatgt gcttagtatt    840

tggtcaccag ccgtcatcct gggcttttcc tactgtgtct tgttacaagg cctcagcaat    900

ccacagaact ctctctcctt ccttccacct gtcagcttct ctgcttctga gataagaacc    960

atttgtgtaa caccaacact taacttcaga aagacatgca ttatgtggtg taatcaaacc   1020

cgatgctttc agatgaccta cttacatctt caatgtggat aagataaaga acaaaacaca   1080

tgcatctaaa ctgctgggca atccagttga cttttaaatg taagaatgga attccaaaca   1140

cttaacacat tcagctatat gacagaaagt aaatctatgg atatggtatt ttgtgaatga   1200

tcttttaaat aaaagaaaac cttacgtaat atttaa                             1236


<210>  3931
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  3931

Met Gly Ser Ser Leu Gly Ala Ala Gly Ser Arg Ser Leu Gly Lys Arg 
1               5                   10                  15


Pro Ser Pro Gly Asp Gly Arg Ala Arg Val Ala Trp Gly Thr Gln Arg 
            20                  25                  30


Asn Val Leu Ser Ile Trp Ser Pro Ala Val Ile Leu Gly Phe Ser Tyr 
        35                  40                  45


Cys Val Leu Leu Gln Gly Leu Ser Asn Pro Gln Asn Ser Leu Ser Phe 
    50                  55                  60


Leu Pro Pro Val Ser Phe Ser Ala Ser Glu Ile Arg Thr Ile Cys Val 
65                  70                  75                  80


Thr Pro Thr Leu Asn Phe Arg Lys Thr Cys Ile Met Trp Cys Asn Gln 
                85                  90                  95


Thr Arg Cys Phe Gln Met Thr Tyr Leu His Leu Gln Cys Gly 
            100                 105                 110


<210>  3932
<211>  359
<212>  DNA
<213>  Homo sapiens

<400>  3932
tcaaatgtca agtcgtttag gtttgttatc cttcttcact ccaagtgttc cattgcttag     60

ttccaaacca ttatcctcta tgaaaagtgt taccagaaat atttggattt gctaagaggt    120

ctctgcatga cggttcatgt aaaagccctg gctttggaat aaggcagacc agagtttcat    180

cagttcagcc atgtgttagt tgtgtgatct gaagtaagtt tcttcacctc tctgagcctc    240

gttttcccca catatgagtt agaaacatgt atttatttat gaaataggct ctccttctgt    300

cacccaggct gaagccatag aatcacttga acctgggagg tggagtttgc agtgagccc     359


<210>  3933
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  3933

Met Ser Ser Arg Leu Gly Leu Leu Ser Phe Phe Thr Pro Ser Val Pro 
1               5                   10                  15


Leu Leu Ser Ser Lys Pro Leu Ser Ser Met Lys Ser Val Thr Arg Asn 
            20                  25                  30


Ile Trp Ile Cys 
        35


<210>  3934
<211>  611
<212>  DNA
<213>  Homo sapiens

<400>  3934
atcccagcac tttggaaggc cgaagcaggc ggatcacttg tggccagaag tttgagacca     60

ccctgaccaa cgtggcaaaa ccccatgtct actaaaaata caaaacgggt gtggcggcac    120

atacctgtaa tcctagctac ttgggaggct gaggcaggag aattgcttga accagggagg    180

cggaggttgc attgagctga gatcatgcca ctgcactcct ccagcctggg cgacagagag    240

agacttctcc ctggaagctt agaacgtaca aagcagactc tgaatgtctt tccaggatca    300

cactctggct tccagcttcc cctggaaggt tcaggagagt atttgtcgcc tggttgcttt    360

tacatcatgc tgattagacc tgcacacccg ggcatgaaat gagtgtgatt gcatcatttt    420

catagaacct aatggcagct gtatgtacgt ctaagacttc ttttgtgtaa gtcgaatgtt    480

cttcgaagtt tccccacgtc atgatttatg tgattttccg tcttgatcag gaccttctga    540

aggagctcaa gtatgtggct gctccacggt tgatgagtct ctggttaagc atggccttcc    600

agttcagggc t                                                         611


<210>  3935
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  3935

Met Pro Leu His Ser Ser Ser Leu Gly Asp Arg Glu Arg Leu Leu Pro 
1               5                   10                  15


Gly Ser Leu Glu Arg Thr Lys Gln Thr Leu Asn Val Phe Pro Gly Ser 
            20                  25                  30


His Ser Gly Phe Gln Leu Pro Leu Glu Gly Ser Gly Glu Tyr Leu Ser 
        35                  40                  45


Pro Gly Cys Phe Tyr Ile Met Leu Ile Arg Pro Ala His Pro Gly Met 
    50                  55                  60


Lys 
65


<210>  3936
<211>  2849
<212>  DNA
<213>  Homo sapiens

<400>  3936
ctgaaggccc cttaagacca ttgagaaaat actctttcct cctacacacc agtgggaatt     60

cagcatttct aaatgagatg cagtttactt ctgccaagag cccacttagc aggcacacaa    120

atgaatgggg aaagaacgct ttgcccccac aggaggcgcc ggtgggggtg aggcgctgtg    180

ctctctgctc atgcccctct gtgtagggca tggccaattt cggataactg ctttgtttac    240

cacacaggtg ctttgcttgt agaatggccc acacctaaaa cgcagccaaa acaggaaaat    300

tgggactttg tgtttttatt ttgtcttcat atagcgtttt cttgtgattt ttgtgttctg    360

agttgtaaat acttctaaat ttcaggttta tcttttaaaa tagctgtata gatttctatt    420

agaaaataga gttcaacctg ctttgaggct ttcttgtttt gcttaagccg tattaaaata    480

cagtttcgtg gtattaatat ttttctactt ttcatgcaag ctgagcatgt aaacagctcg    540

tttgtttgct ctcctaagat cttgattcct ttttctttgg gaagtctgtt agcgctgtca    600

ttactccaca cattggcatt tggacccact tttaacacac tttattttgg agagacttca    660

gatagtggac aaactaaaga atttaaaatg aaactcaaac aattcccaga acattattct    720

ataagcagct tggagacgat agtttgaaaa gtaattcagt gtcctgtttc ttcctcaggc    780

ttcagggatg acttcttagg gggcagggga ggtagtcgcc caggcgaccg gcgaacaggc    840

ccccccatgg gcagccgctt cagagatggc cctcccctcc gtggatccaa catggatttc    900

agagaaccca cagaagagga aagagcacag agaccacgac tccagcttaa acctcgaaca    960

gtcgcgacgc ccctcaatca agtagccaat cccaactctg ctatcttcgg gggtgccagg   1020

cctagagagg aagtcgttca aaaggagcaa gaatgagcct gcggttggga gggaatgggg   1080

cgtggggggt tagagcagga ccacagcctg gtgagtcccc gggcagccgt cctgcagccg   1140

ccactcctgc gcctgccatt ggcctcctca cagcggaaac acagcttgtg agtgcatgtc   1200

agctgttaac aagtggtttt tagtacattc tgggctttgc tgtatctatc tagtgcctgt   1260

ttgtgcgttt ttttctttct tccgctgctt ccccattttc cttctgtcct ttttctcctg   1320

ctccttgttt tcccagcagc acatggggtt cctcggagga gcagaggtgg ccgccgtggg   1380

ggggcgtttg ggctgcggtg ctgcgtcatt tttcctttgc tttctcttta ctttagacac   1440

tggcccaact ccaggcgttt cctttcattc cctcagtgct tctcttctga cctgcatgtt   1500

gagttctgta ttgctggggc ttccaacaaa aaccagagtc actgacagag ggaacagcag   1560

agaccttgtt ggtattcagc tgtgatggat atagagaatc agaggcacct tgttttcaca   1620

actaggataa aaatatctgc agggtccttt ccattcctat ttagagggag tcctggctcc   1680

atgaccccct cccgagtgga ctgtccaagc agataggctc acacgagaaa cagtgaggct   1740

gaaagggggg gctatggaag agcggtaggg agtccacgga gaagatgcag tgaatgcttg   1800

catgcattca cacgtgtgtg tgtcccagct agttcactcc tttcgccgtg cgtggtggag   1860

gctggcctct ctggctgggt gcagtgaatg gccagcgggt ttcttttctg ctgggccaag   1920

gcgctttggg ggtggagggg gtggtgctgg tgctgcactg ggctgactgc ggcgctgacg   1980

cagcgtttcc ccccatccct gttgcctgtg tgttgtgtgg atctgttcct agtataggca   2040

acataatgag atactgtgct tcccacctcc ccttcagttc agagccaaaa tgggtctaga   2100

atctggcact ttactcattt cctttgataa attgtactat gcagagctgt caggaacctt   2160

cagatagcag tagaggactg cagctgtcta ggtctgcggc cacatcttgg ggacacactg   2220

gactgttccc atgtgcaggg ttcagcagtt atgtgggagt gctaggggtt aggcttttga   2280

gcttgaacgc ctgcgtgtga acagatgaaa aatccttcag tacccaagtc ccagtctgtc   2340

ctatggggag cagtttgggg gcggccggca gcaggagcct gggaaagagg ccctcgccag   2400

gtgatggcag ggccagggtg gcctggggca cccagcggaa tgtgcttagt atttggtcac   2460

cagccgtcat cctgggcttt tcctactgtg tcttgttaca aggcctcagc aatccacaga   2520

actctctctc cttccttcca cctgtcagct tctctgcttc tgagataaga accatttgtg   2580

taacaccaac acttaacttc agaaagacat gcattatgtg gtgtaatcaa acccgatgct   2640

ttcagatgac ctacttacat cttcaatgtg gataagataa agaacaaaac acatgcatct   2700

aaactgctgg gcaatccagt tgacttttaa atgtaagaat ggaattccaa acacttaaca   2760

cattcagcta tatgacagaa agtaaatcta tggatatggt attttgtgaa tgatctttta   2820

aataaaagaa aaccttacgt aatatttaa                                     2849


<210>  3937
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  3937

Met Gly Ser Arg Phe Arg Asp Gly Pro Pro Leu Arg Gly Ser Asn Met 
1               5                   10                  15


Asp Phe Arg Glu Pro Thr Glu Glu Glu Arg Ala Gln Arg Pro Arg Leu 
            20                  25                  30


Gln Leu Lys Pro Arg Thr Val Ala Thr Pro Leu Asn Gln Val Ala Asn 
        35                  40                  45


Pro Asn Ser Ala Ile Phe Gly Gly Ala Arg Pro Arg Glu Glu Val Val 
    50                  55                  60


Gln Lys Glu Gln Glu 
65


<210>  3938
<211>  1436
<212>  DNA
<213>  Homo sapiens

<400>  3938
cccagaggaa agagcacaga gaccacgact ccagcttaaa cctcgaacag tcgcgacgcc     60

cctcaatcaa gtagccaatc ccaactctgc tatcttcggg ggtgccaggc ctagagagga    120

agtcgttcaa aaggagcaag aatgagcctg cggttgggag ggaatggggc gtggggggtt    180

agagcaggac cacagcctgg tgagtccccg ggcagccgtc ctgcagccgc cactcctgcg    240

cctgccattg gcctcctcac agcggaaaca cagcttgtga gtgcatgtca gctgttaaca    300

agtggttttt agtacattct gggctttgct gtatctatct agtgcctgtt tgtgcgtttt    360

tttctttctt ccgctgcttc cccattttcc ttctgtcctt tttctcctgc tccttgtttt    420

cccagcagca catggggttc ctcggaggag cagaggtggc cgccgtgggg gggcgtttgg    480

gctgcggtgc tgcgtcattt ttcctttgct ttctctttac tttagacact ggcccaactc    540

caggcgtttc ctttcattcc ctcagtgctt ctcttctgac ctgcatgttg acctgtgtgt    600

tgtgtggatc tgttcctagt ataggcaaca taatgagata ctgtgcttcc cacctcccct    660

tcagttcaga gccaaaatgg gtctagaatc tggcacttta ctcatttcct ttgataaatt    720

gtactatgca gagctgtcag gaaccttcag atagcagtag aggactgcag ctgtctaggt    780

ctgcggccac atcttgggga cacactggac tgttcccatg tgcagggttc agcagttatg    840

tgggagtgct aggggttagg cttttgagct tgaacgcctg cgtgtgaaca gatgaaaaat    900

ccttcagtac ccaagtccca gtctgtccta tggggagcag tttgggggcg gccggcagca    960

ggagcctggg aaagaggccc tcgccaggtg atggcagggc cagggtggcc tggggcaccc   1020

agcggaatgt gcttagtatt tggtcaccag ccgtcatcct gggcttttcc tactgtgtct   1080

tgttacaagg cctcagcaat ccacagaact ctctctcctt ccttccacct gtcagcttct   1140

ctgcttctga gataagaacc atttgtgtaa caccaacact taacttcaga aagacatgca   1200

ttatgtggtg taatcaaacc cgatgctttc agatgaccta cttacatctt caatgtggat   1260

aagataaaga acaaaacaca tgcatctaaa ctgctgggca atccagttga cttttaaatg   1320

taagaatgga attccaaaca cttaacacat tcagctatat gacagaaagt aaatctatgg   1380

atatggtatt ttgtgaatga tcttttaaat aaaagaaaac cttacgtaat atttaa       1436


<210>  3939
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  3939

Met Ser Ala Val Asn Lys Trp Phe Leu Val His Ser Gly Leu Cys Cys 
1               5                   10                  15


Ile Tyr Leu Val Pro Val Cys Ala Phe Phe Ser Phe Phe Arg Cys Phe 
            20                  25                  30


Pro Ile Phe Leu Leu Ser Phe Phe Ser Cys Ser Leu Phe Ser Gln Gln 
        35                  40                  45


His Met Gly Phe Leu Gly Gly Ala Glu Val Ala Ala Val Gly Gly Arg 
    50                  55                  60


Leu Gly Cys Gly Ala Ala Ser Phe Phe Leu Cys Phe Leu Phe Thr Leu 
65                  70                  75                  80


Asp Thr Gly Pro Thr Pro Gly Val Ser Phe His Ser Leu Ser Ala Ser 
                85                  90                  95


Leu Leu Thr Cys Met Leu Thr Cys Val Leu Cys Gly Ser Val Pro Ser 
            100                 105                 110


Ile Gly Asn Ile Met Arg Tyr Cys Ala Ser His Leu Pro Phe Ser Ser 
        115                 120                 125


Glu Pro Lys Trp Val 
    130


<210>  3940
<211>  974
<212>  DNA
<213>  Homo sapiens

<400>  3940
ggaaagagca cagagaccac gactccagct taaacctcga acagtcgcga cgcccctcaa     60

tcaagtagcc aatcccaact ctgctatctt cgggggtgcc aggcctagag aggaagtcgt    120

tcaaaaggag caagaatgag cctgcggttg ggagggaatg gggcgtgggg ggttagagca    180

ggaccacagc ctggtgagtc cccgggcagc cgtcctgcag ccgccactcc tgcgcctgcc    240

attggcctcc tcacagcgga aacacagctt gtgagtgcat gtcagctgtt aacaagtggt    300

ttttagtaca ttctgggctt tgctgtatct atctagtgcc tgtttgtgcg tttttttctt    360

tcttccgctg cttccccatt ttccttctgt cctttttctc ctgctccttg ttttcccagc    420

agcacatggg gttcctcgga ggagcagagg tggccgccgt gggggggcgt ttgggctgcg    480

gtgctgcgtc atttttcctt tgctttctct ttactttaga cactggccca actccaggcg    540

tttcctttca ttccctcagt gcttctcttc tgacctgcat gttgagttct gtattgctgg    600

ggttttccta ctgtgtcttg ttacaaggcc tcagcaatcc acagaactct ctctccttcc    660

ttccacctgt cagcttctct gcttctgaga taagaaccat ttgtgtaaca ccaacactta    720

acttcagaaa gacatgcatt atgtggtgta atcaaacccg atgctttcag atgacctact    780

tacatcttca atgtggataa gataaagaac aaaacacatg catctaaact gctgggcaat    840

ccagttgact tttaaatgta agaatggaat tccaaacact taacacattc agctatatga    900

cagaaagtaa atctatggat atggtatttt gtgaatgatc ttttaaataa aagaaaacct    960

tacgtaatat ttaa                                                      974


<210>  3941
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  3941

Met Ser Ala Val Asn Lys Trp Phe Leu Val His Ser Gly Leu Cys Cys 
1               5                   10                  15


Ile Tyr Leu Val Pro Val Cys Ala Phe Phe Ser Phe Phe Arg Cys Phe 
            20                  25                  30


Pro Ile Phe Leu Leu Ser Phe Phe Ser Cys Ser Leu Phe Ser Gln Gln 
        35                  40                  45


His Met Gly Phe Leu Gly Gly Ala Glu Val Ala Ala Val Gly Gly Arg 
    50                  55                  60


Leu Gly Cys Gly Ala Ala Ser Phe Phe Leu Cys Phe Leu Phe Thr Leu 
65                  70                  75                  80


Asp Thr Gly Pro Thr Pro Gly Val Ser Phe His Ser Leu Ser Ala Ser 
                85                  90                  95


Leu Leu Thr Cys Met Leu Ser Ser Val Leu Leu Gly Phe Ser Tyr Cys 
            100                 105                 110


Val Leu Leu Gln Gly Leu Ser Asn Pro Gln Asn Ser Leu Ser Phe Leu 
        115                 120                 125


Pro Pro Val Ser Phe Ser Ala Ser Glu Ile Arg Thr Ile Cys Val Thr 
    130                 135                 140


Pro Thr Leu Asn Phe Arg Lys Thr Cys Ile Met Trp Cys Asn Gln Thr 
145                 150                 155                 160


Arg Cys Phe Gln Met Thr Tyr Leu His Leu Gln Cys Gly 
                165                 170


<210>  3942
<211>  827
<212>  DNA
<213>  Homo sapiens

<400>  3942
tctgttgatg gacacttaga tttcttccaa atcttggctg ttgtgaacag tggcgcaata     60

aatatggcag tgcaggtatc tcttcgaggt acaaaattcc tttctttggg gtatataccc    120

ggcagtggga ttgctggatc atatggtagc tcaattttta gttttgtgag gaacctccaa    180

accattttcc atagtgggtg tagtaattta tgttcccacc agtagggtac aagggttccc    240

ttttcttcac atccttgcca gcatttgtta tttatatcac agttcaaaaa aataatgtaa    300

tataccaaaa acgattgagt tgtggggaaa aaaaaatata agtgcactag aatttatgca    360

actgaacagg aactgtctag tttgttgtct tttttttttt tttttttgag acagggtgtc    420

attctgtcac ccaggctgca gttcagtggc gtgatctcgg ctcactgcaa cctccacctc    480

ccgggttcaa gcgtcagcct cccgagtatc tgggatttac aggcgcagcc gtgcattgaa    540

agtaatggta aaaaccacaa ttacttttgt gccaacctaa taccatccca caccagtgtc    600

ccacagtcac accccccctt gtggttaaac tttctctcag cagctgttga aaagtttttc    660

ctctctccga taattctgct gatggcctct gcagagctga ttaaacagtg ttgtgactgt    720

ctcatgggaa gagctggggc ccagagggac cttgagtcag aaatgttgcc agaaaaagta    780

tctcctccaa ccaaaacatc tcaataaaac cattttagtt gaaaagc                  827


<210>  3943
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  3943

Met Ala Ser Ala Glu Leu Ile Lys Gln Cys Cys Asp Cys Leu Met Gly 
1               5                   10                  15


Arg Ala Gly Ala Gln Arg Asp Leu Glu Ser Glu Met Leu Pro Glu Lys 
            20                  25                  30


Val Ser Pro Pro Thr Lys Thr Ser Gln 
        35                  40


<210>  3944
<211>  1856
<212>  DNA
<213>  Homo sapiens

<400>  3944
cattatcttg ctccctgtct attggagtgt atctctcttc ctctctgtgt gactttttgt     60

gtttatgtgt gtgtttagtg tgtgtccata ttttcctgtt ctcttgtgtc tctctgctgt    120

gtctctctct ttttctttct gttttttgag acggagtctc cctctgtcac ccaggctgga    180

gtgcagtggt gcgatctcgg ctcactgcaa cctctgcttc tgaggttcaa acgattctcc    240

tgcctcagcc tcccgagtag ctggaattac agacacatgc caccatgccc agctaatttt    300

gtatttttaa tagagacggg gtttcaccat gttggccagg ctggtcttaa actcttgacc    360

ttacgtgatc cacccgcctc ggcctcccaa agtttttgga ttacaggtgt gagccacctc    420

gcccggtcct atctctcttt cttctctttc tccctctcac tttgtttctc ttctctctct    480

ctctcccgcc tccttccccc gtctcccctc ccttcccccc accgccctct tcatagctga    540

gcctgtccgg cagtgcggcg gatgtacgga tgattcagtg gctggcagga agcccgccct    600

gcccgcccgc cagtgtcagt ggtgttggca tcagcttggg caggtgtgcg ggctcaggat    660

ggggcggccg tggtgaggaa ccctggactc tcagagatgg aatttcaccg tgttgcctag    720

gctggtctgg agctcttgat ctcaagcgat cctccctgcc tcggcctccc aacgtgctgg    780

gattataggc gtgagccacc gctcctggcc agggtctgtt cctagttgca acagttcttg    840

gaaacccact cgagagggcc acgcctccat tcaccaggcc acggtgggtg gtgtgcgtat    900

gttttgctga ggcctggtca tcacgctgtg gctccaaggc tgggaccagc cacagaccga    960

gaagccggtc aggtgccagc cagagattca gggctccctc cctctgaaca tcctgtcttt   1020

agcccatcct tggcatccca gctcatgtca tcccagccac ctgcagcagt gccctagggc   1080

cccatccctc tgcggatcat gctcttgggc cacctcctcc aagaagcctt ccctgacctc   1140

cctcctccca gctcccacca caggcagaat ctgggcttgc agttgtttca ggaatggaag   1200

ccccattccc aggtcctggg gggaccccaa ggcaggaggt gggcagagag gggtcctgcg   1260

aagcatagag gagccctgag ttgctctggg gtgggcgagg gcttccgggt gcgtctgcgt   1320

gagtggtggc cacagactgt cacctccagg agccagggtg ggtttactgg aggcaaccca   1380

ctgtgggttg atgggcagag ccagggttag gggcaggaca ctggggcctg aatcccatct   1440

ttccacttag cagacgtgag ctctctggcc tcagtttctc gatttgtgaa atgcagtgaa   1500

cctcgtcctc aaagggcagt tgtctagatt aagcgaggct gtgtgtaggg ctgtgtgcgt   1560

gcacatgggg ctgtcttgtg ggcccccaga accttccagc acttatcaag ggtgaagatg   1620

gcccacaggg cagaggtgtt ggtttggggt cacatggggt gaacaggact ggttctgtcc   1680

ttgcccagtg caggagcggg gaggggaggt ggtgtttccg cagcctaggc tcaggtatgg   1740

ggctgtccga gcacagtggg ggtgtggggt aggattcctg aaaaaggggc cccttgctca   1800

cgggcacctc ccatttcagc atcacaagag gcaacaccag gagccaacat gagctc       1856


<210>  3945
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  3945

Met Ile Gln Trp Leu Ala Gly Ser Pro Pro Cys Pro Pro Ala Ser Val 
1               5                   10                  15


Ser Gly Val Gly Ile Ser Leu Gly Arg Cys Ala Gly Ser Gly Trp Gly 
            20                  25                  30


Gly Arg Gly Glu Glu Pro Trp Thr Leu Arg Asp Gly Ile Ser Pro Cys 
        35                  40                  45


Cys Leu Gly Trp Ser Gly Ala Leu Asp Leu Lys Arg Ser Ser Leu Pro 
    50                  55                  60


Arg Pro Pro Asn Val Leu Gly Leu 
65                  70


<210>  3946
<211>  1320
<212>  DNA
<213>  Homo sapiens

<400>  3946
cattatcttg ctccctgtct attggagtgt atctctcttc ctctctgtgt gactttttgt     60

gtttatgtgt gtgtttagtg tgtgtccata ttttcctgtt ctcttgtgtc tctctgctgt    120

gtctctctct ttttctttct gttttttgag acggagtctc cctctgtcac ccaggctgga    180

gtgcagtggt gcgatctcgg ctcactgcaa cctctgcttc tgaggttcaa acgattctcc    240

tgcctcagcc tcccgagtag ctggaattac agacacatgc caccatgccc agctaatttt    300

gtatttttaa tagagacggg gtttcaccat gttggccagg ctggtcttaa actcttgacc    360

ttacgtgatc cacccgcctc ggcctcccaa agtttttgga ttacaggtgt gagccacctc    420

gcccggtcct atctctcttt cttctctttc tccctctcac tttgtttctc ttctctctct    480

ctctcccgcc tccttccccc gtctcccctc ccttcccccc accgccctct tcatagctga    540

gcctgtccgg cagtgcggcg gatgtacgga tgattcagtg gctggcagga agcccgccct    600

gcccgcccgc cagtgtcagt ggtgttggca tcagcttggg caggtgtgcg ggctcaggat    660

ggggcggccg tggtgaggaa ccctggactc tcagagatgg aatttcaccg tgttgcctag    720

gctggtctgg agctcttgat ctcaagcgat cctccctgcc tcggcctccc aacgtgctgg    780

gattataggc gtgagccacc gctcctggcc aggcatcaca agaggcaaca ccaggagcca    840

acatgagctc ggggactgaa ctgctgtggc ccggagcagc gctgctggtg ctgttggggg    900

tggcagccag tctgtgtgtg cgctgctcac gcccaggtgc aaagaggtca gagaaaatct    960

accagcagag aagtctgcgt gaggaccaac agagctttac ggggtcccgg acctactcct   1020

tggtcgggca ggcatggcca ggacccctgg cggacatggc acccacaagg aaggacaagc   1080

tgttgcaatt ctaccccagc ctggaggatc cagcatcttc caggtaccag aacttcagca   1140

aaggaagcag acacgggtcg gaggaagcct acatagaccc cattgccatg gagtattaca   1200

actgggggcg gttctcgaag cccccagaag gtgaggcgaa ggacaaagcc ggaggtggag   1260

gaagtggtgt gggagctcag ggcagaagcc atacctccag gcaggagagg aggctgggcc   1320


<210>  3947
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  3947

Met Ser Ser Gly Thr Glu Leu Leu Trp Pro Gly Ala Ala Leu Leu Val 
1               5                   10                  15


Leu Leu Gly Val Ala Ala Ser Leu Cys Val Arg Cys Ser Arg Pro Gly 
            20                  25                  30


Ala Lys Arg Ser Glu Lys Ile Tyr Gln Gln Arg Ser Leu Arg Glu Asp 
        35                  40                  45


Gln Gln Ser Phe Thr Gly Ser Arg Thr Tyr Ser Leu Val Gly Gln Ala 
    50                  55                  60


Trp Pro Gly Pro Leu Ala Asp Met Ala Pro Thr Arg Lys Asp Lys Leu 
65                  70                  75                  80


Leu Gln Phe Tyr Pro Ser Leu Glu Asp Pro Ala Ser Ser Arg Tyr Gln 
                85                  90                  95


Asn Phe Ser Lys Gly Ser Arg His Gly Ser Glu Glu Ala Tyr Ile Asp 
            100                 105                 110


Pro Ile Ala Met Glu Tyr Tyr Asn Trp Gly Arg Phe Ser Lys Pro Pro 
        115                 120                 125


Glu Gly Glu Ala Lys Asp Lys Ala Gly Gly Gly Gly Ser Gly Val Gly 
    130                 135                 140


Ala Gln Gly Arg Ser His Thr Ser Arg Gln Glu Arg Arg Leu 
145                 150                 155


<210>  3948
<211>  3021
<212>  DNA
<213>  Homo sapiens

<400>  3948
cattatcttg ctccctgtct attggagtgt atctctcttc ctctctgtgt gactttttgt     60

gtttatgtgt gtgtttagtg tgtgtccata ttttcctgtt ctcttgtgtc tctctgctgt    120

gtctctctct ttttctttct gttttttgag acggagtctc cctctgtcac ccaggctgga    180

gtgcagtggt gcgatctcgg ctcactgcaa cctctgcttc tgaggttcaa acgattctcc    240

tgcctcagcc tcccgagtag ctggaattac agacacatgc caccatgccc agctaatttt    300

gtatttttaa tagagacggg gtttcaccat gttggccagg ctggtcttaa actcttgacc    360

ttacgtgatc cacccgcctc ggcctcccaa agtttttgga ttacaggtgt gagccacctc    420

gcccggtcct atctctcttt cttctctttc tccctctcac tttgtttctc ttctctctct    480

ctctcccgcc tccttccccc gtctcccctc ccttcccccc accgccctct tcatagctga    540

gcctgtccgg cagtgcggcg gatgtacgga tgattcagtg gctggcagga agcccgccct    600

gcccgcccgc cagtgtcagt ggtgttggca tcagcttggg caggtgtgcg ggctcaggat    660

ggggcggccg tggtgaggaa ccctggactc tcagcatcac aagaggcaac accaggagcc    720

aacatgagct cggggactga actgctgtgg cccggagcag cgctgctggt gctgttgggg    780

gtggcagcca gtctgtgtgt gcgctgctca cgcccaggtg caaagaggtc agagaaaatc    840

taccagcaga gaagtctgcg tgaggaccaa cagagcttta cggggtcccg gacctactcc    900

ttggtcgggc aggcatggcc aggacccctg gcggacatgg cacccacaag gaaggacaag    960

ctgttgcaat tctaccccag cctggaggat ccagcatctt ccaggtacca gaacttcagc   1020

aaaggaagca gacacgggtc ggaggaagcc tacatagacc ccattgccat ggagtattac   1080

aactgggggc ggttctcgaa gcccccagaa gatgatgatg ccaattccta cgagaatgtg   1140

ctcatttgca agcagaaaac cacagagaca ggtgcccagc aggagggcat aggtggcctc   1200

tgcagagggg acctcagcct gtcactggcc ctgaagactg gccccacttc tggtctctgt   1260

ccctctgcct ccccggaaga agatgaggaa tctgaggatt atcagaactc agcatccatc   1320

catcagtggc gcgagtccag gaaggtcatg gggcaactcc agagagaagc atcccctggc   1380

ccggtgggaa gcccagacga ggaggacggg gaaccggatt acgtgaatgg ggaggtggca   1440

gccacagaag cctagggcag accaagaaga aaggggcgtc aggcagggaa ttctggtgac   1500

ttcaggggca aagaagtggg caccgggtgg gtctcccaac tccactgcat cctcctggct   1560

gcgaccttgg accaagtgac aacctcccag aacttagttc ctcacttggt gcccacctct   1620

cagagaagac atcgcacaca cggccgggca cggtggctca cgcctgtaat cccggcactt   1680

tgggaggccg aggcaggcag atcacctgag gtcacgagtt cgagaccagc ctggccaaca   1740

tggtgaaact tcatctctac taaaaacaca aaaaattagc caggcatggt ggtgggtgcc   1800

tgtagtccca gttagttggg aggctgaggc aggagaatca tttgaaccct gaaggcggag   1860

gttgcggtga gttaagatca catgcactca accctgggtg acagagcgag actccgtctc   1920

aataaataaa taaaaaaaca gacattgcac acaaagcctc agcccagcag gcactcggtc   1980

aatgctggaa acagacagga ggcagggacg ttgggaaatg taacagtggc tgagacgcgc   2040

tgaggagcca ccgcaggcca gtgagatggt gcggcgctaa gcgctcacac gtgcaccatc   2100

tcttagcacc caaagccaca gagcagttaa gccacctgcc caaggccaca tcttgaagta   2160

aggggaggag gagatggaat ccccagtggt cagacatcag acatcaaagc ctaggctggg   2220

tctactgctt gggaagcacg atggaccccc agagggcctt gaaggctgcc caaagtcccc   2280

atctgggaga cccaggccgt catctcagcg agcaggctgg agggtggaaa ccacagtgaa   2340

cctgggtggt caagagtcag ccccagaggc aggtgcagga gtttgagcca aatgtgcaga   2400

gccccacgtc attcattcaa ccagtatcca ctgggcccct gctacgggca agtcctgctc   2460

taggtgctgg gaacaccaac ataaagaaca gcaaacccct gaccccttag aacttgcatt   2520

ctggtaggag agagaaaaca gatagggctg gacacagcgg tcatgcctat aaatcccagc   2580

acttcgggag gctgaggcgg gaggatcctt tgagcctctg agtttgaggc cagcctgggc   2640

aacatagcaa gacctctctc tctacaaaaa cttttttttt ttttttttga gacagagtat   2700

cactgtcact caggctggag tgcagtggcg ccatctcggc tcactgcaac ctccacctcc   2760

tgggttcaag cgattctcgt gcctcagcct tccaagtagc tgggattaca ggcacacgcc   2820

accatgtcca gcctctataa aaacatttaa aattagccag gcatggtggt ggatgcccta   2880

gagtcccact gacttgggag gctgaggtgg gaagatcact tgagcctggg aggtcaaggt   2940

tgcaatgagc catggttgct gcagtgagct gtggtcgtgc cactgcactc aagcctgggc   3000

aacagagcaa gaccccatct c                                             3021


<210>  3949
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  3949

Met Ser Ser Gly Thr Glu Leu Leu Trp Pro Gly Ala Ala Leu Leu Val 
1               5                   10                  15


Leu Leu Gly Val Ala Ala Ser Leu Cys Val Arg Cys Ser Arg Pro Gly 
            20                  25                  30


Ala Lys Arg Ser Glu Lys Ile Tyr Gln Gln Arg Ser Leu Arg Glu Asp 
        35                  40                  45


Gln Gln Ser Phe Thr Gly Ser Arg Thr Tyr Ser Leu Val Gly Gln Ala 
    50                  55                  60


Trp Pro Gly Pro Leu Ala Asp Met Ala Pro Thr Arg Lys Asp Lys Leu 
65                  70                  75                  80


Leu Gln Phe Tyr Pro Ser Leu Glu Asp Pro Ala Ser Ser Arg Tyr Gln 
                85                  90                  95


Asn Phe Ser Lys Gly Ser Arg His Gly Ser Glu Glu Ala Tyr Ile Asp 
            100                 105                 110


Pro Ile Ala Met Glu Tyr Tyr Asn Trp Gly Arg Phe Ser Lys Pro Pro 
        115                 120                 125


Glu Asp Asp Asp Ala Asn Ser Tyr Glu Asn Val Leu Ile Cys Lys Gln 
    130                 135                 140


Lys Thr Thr Glu Thr Gly Ala Gln Gln Glu Gly Ile Gly Gly Leu Cys 
145                 150                 155                 160


Arg Gly Asp Leu Ser Leu Ser Leu Ala Leu Lys Thr Gly Pro Thr Ser 
                165                 170                 175


Gly Leu Cys Pro Ser Ala Ser Pro Glu Glu Asp Glu Glu Ser Glu Asp 
            180                 185                 190


Tyr Gln Asn Ser Ala Ser Ile His Gln Trp Arg Glu Ser Arg Lys Val 
        195                 200                 205


Met Gly Gln Leu Gln Arg Glu Ala Ser Pro Gly Pro Val Gly Ser Pro 
    210                 215                 220


Asp Glu Glu Asp Gly Glu Pro Asp Tyr Val Asn Gly Glu Val Ala Ala 
225                 230                 235                 240


Thr Glu Ala 



<210>  3950
<211>  2553
<212>  DNA
<213>  Homo sapiens

<400>  3950
cattatcttg ctccctgtct attggagtgt atctctcttc ctctctgtgt gactttttgt     60

gtttatgtgt gtgtttagtg tgtgtccata ttttcctgtt ctcttgtgtc tctctgctgt    120

gtctctctct ttttctttct gttttttgag acggagtctc cctctgtcac ccaggctgga    180

gtgcagtggt gcgatctcgg ctcactgcaa cctctgcttc tgaggttcaa acgattctcc    240

tgcctcagcc tcccgagtag ctggaattac agacacatgc caccatgccc agctaatttt    300

gtatttttaa tagagacggg gtttcaccat gttggccagg ctggtcttaa actcttgacc    360

ttacgtgatc cacccgcctc ggcctcccaa agtttttgga ttacaggtgt gagccacctc    420

gcccggtcct atctctcttt cttctctttc tccctctcac tttgtttctc ttctctctct    480

ctctcccgcc tccttccccc gtctcccctc ccttcccccc accgccctct tcatagctga    540

gcctgtccgg cagtgcggcg gatgtacgga tgattcagtg gctggcagga agcccgccct    600

gcccgcccgc cagtgtcagt ggtgttggca tcagcttggg caggtgtgcg ggctcaggat    660

ggggcggccg tggtgaggaa ccctggactc tcagagatgg aatttcaccg tgttgcctag    720

gctggtctgg agctcttgat ctcaagcgat cctccctgcc tcggcctccc aacgtgctgg    780

gattataggc gtgagccacc gctcctggcc agggtctgtt cctagttgca acagttcttg    840

gaaacccact cgagagggcc acgcctccat tcaccaggcc acgcatcaca agaggcaaca    900

ccaggagcca acatgagctc ggggactgaa ctgctgtggc ccggagcagc gctgctggtg    960

ctgttggggg tggcagccag tctgtgtgtg cgctgctcac gcccaggtgc aaagaggtca   1020

gagaaaatct accagcagag aagtctgcgt gaggaccaac agagctttac ggggtcccgg   1080

acctactcct tggtcgggca ggcatggcca ggacccctgg cggacatggc acccacaagg   1140

aaggacaagc tgttgcaatt ctaccccagc ctggaggatc cagcatcttc caggtaccag   1200

aacttcagca aaggaagcag acacgggtcg gaggaagcct acatagaccc cattgccatg   1260

gagtattaca actgggggcg gttctcgaag cccccagaag atgatgatgc caattcctac   1320

gagaatgtgc tcatttgcaa gcagaaaacc acagagacag gtgcccagca ggagggcata   1380

ggtggcctct gcagagggga cctcagcctg tcactggccc tgaagactgg ccccacttct   1440

ggtctctgtc cctctgcctc cccggaagaa gatgaggaat ctgaggatta tcagaactca   1500

gcatccatcc atcagtggcg cgagtccagg aaggtcatgg ggcaactcca gagagaagca   1560

tcccctggcc cggtgggaag cccagacgag gaggacgggg aaccggatta cgtgaatggg   1620

gaggtggcag ccacagaagc ctagggcaga ccaagaagaa aggagccaag gcaaagaggg   1680

accactgtgc tcatggaccc atcgctgcct tccaaggacc atttcccaga gctactcaac   1740

ttttaagccc ctgccatggt tgctcctgga aggagaacca gccaccctga ggaccacctg   1800

gccatgcgtg cacagcctgg gaaaagacag ttactcacgg gagctgcagg cccgtcacca   1860

agccctctcc cgacccaggc tttgtggggc aggcacctgg taccaagggt aacccggctc   1920

ctggtatgga cggatgcgca ggatttagga taagctgtca cccagtcccc ataacaaaac   1980

cactgtccaa cactggtatc tgtgttcttt tgtgctatga atttggattc ctaattgcta   2040

ttgttggttg ctggggtttt aaatgattga taagcttgta cagttaactt atagaggggg   2100

agccatattt aacattctgg atttcagagt agagatttct gtgttgtctc ctagaaagca   2160

ttacatgtag tttatttcag catccttgtt gggtggggcc ctggctctct tcccctttgg   2220

tgggacctcc cctttctttg ggcttcagtt cactcaggaa gaaatgaggc tgtcgccatc   2280

tttatgtgct tccagtggaa atgtcacttg ctacagacaa tagtgcatga gagtctagag   2340

aagtagtgac cagaacaggg cagagtaggt cccctccatg gccctgaatc ctcctctgct   2400

ccagggctgg cctctgcaga gctgattaaa cagtgttgtg actgtctcat gggaagagct   2460

ggggcccaga gggaccttga gtcagaaatg ttgccagaaa aagtatctcc tccaaccaaa   2520

acatctcaat aaaaccattt tagttgaaaa gca                                2553


<210>  3951
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  3951

Met Ser Ser Gly Thr Glu Leu Leu Trp Pro Gly Ala Ala Leu Leu Val 
1               5                   10                  15


Leu Leu Gly Val Ala Ala Ser Leu Cys Val Arg Cys Ser Arg Pro Gly 
            20                  25                  30


Ala Lys Arg Ser Glu Lys Ile Tyr Gln Gln Arg Ser Leu Arg Glu Asp 
        35                  40                  45


Gln Gln Ser Phe Thr Gly Ser Arg Thr Tyr Ser Leu Val Gly Gln Ala 
    50                  55                  60


Trp Pro Gly Pro Leu Ala Asp Met Ala Pro Thr Arg Lys Asp Lys Leu 
65                  70                  75                  80


Leu Gln Phe Tyr Pro Ser Leu Glu Asp Pro Ala Ser Ser Arg Tyr Gln 
                85                  90                  95


Asn Phe Ser Lys Gly Ser Arg His Gly Ser Glu Glu Ala Tyr Ile Asp 
            100                 105                 110


Pro Ile Ala Met Glu Tyr Tyr Asn Trp Gly Arg Phe Ser Lys Pro Pro 
        115                 120                 125


Glu Asp Asp Asp Ala Asn Ser Tyr Glu Asn Val Leu Ile Cys Lys Gln 
    130                 135                 140


Lys Thr Thr Glu Thr Gly Ala Gln Gln Glu Gly Ile Gly Gly Leu Cys 
145                 150                 155                 160


Arg Gly Asp Leu Ser Leu Ser Leu Ala Leu Lys Thr Gly Pro Thr Ser 
                165                 170                 175


Gly Leu Cys Pro Ser Ala Ser Pro Glu Glu Asp Glu Glu Ser Glu Asp 
            180                 185                 190


Tyr Gln Asn Ser Ala Ser Ile His Gln Trp Arg Glu Ser Arg Lys Val 
        195                 200                 205


Met Gly Gln Leu Gln Arg Glu Ala Ser Pro Gly Pro Val Gly Ser Pro 
    210                 215                 220


Asp Glu Glu Asp Gly Glu Pro Asp Tyr Val Asn Gly Glu Val Ala Ala 
225                 230                 235                 240


Thr Glu Ala 



<210>  3952
<211>  2364
<212>  DNA
<213>  Homo sapiens

<400>  3952
cattatcttg ctccctgtct attggagtgt atctctcttc ctctctgtgt gactttttgt     60

gtttatgtgt gtgtttagtg tgtgtccata ttttcctgtt ctcttgtgtc tctctgctgt    120

gtctctctct ttttctttct gttttttgag acggagtctc cctctgtcac ccaggctgga    180

gtgcagtggt gcgatctcgg ctcactgcaa cctctgcttc tgaggttcaa acgattctcc    240

tgcctcagcc tcccgagtag ctggaattac agacacatgc caccatgccc agctaatttt    300

gtatttttaa tagagacggg gtttcaccat gttggccagg ctggtcttaa actcttgacc    360

ttacgtgatc cacccgcctc ggcctcccaa agtttttgga ttacaggtgt gagccacctc    420

gcccggtcct atctctcttt cttctctttc tccctctcac tttgtttctc ttctctctct    480

ctctcccgcc tccttccccc gtctcccctc ccttcccccc accgccctct tcatagctga    540

gcctgtccgg cagtgcggcg gatgtacgga tgattcagtg gctggcagga agcccgccct    600

gcccgcccgc cagtgtcagt ggtgttggca tcagcttggg caggtgtgcg ggctcaggat    660

ggggcggccg tggtgaggaa ccctggactc tcagcatcac aagaggcaac accaggagcc    720

aacatgagct cggggactga actgctgtgg cccggagcag cgctgctggt gctgttgggg    780

gtggcagcca gtctgtgtgt gcgctgctca cgcccaggtg caaagaggtc agagaaaatc    840

taccagcaga gaagtctgcg tgaggaccaa cagagcttta cggggtcccg gacctactcc    900

ttggtcgggc aggcatggcc aggacccctg gcggacatgg cacccacaag gaaggacaag    960

ctgttgcaat tctaccccag cctggaggat ccagcatctt ccaggtacca gaacttcagc   1020

aaaggaagca gacacgggtc ggaggaagcc tacatagacc ccattgccat ggagtattac   1080

aactgggggc ggttctcgaa gcccccagaa gatgatgatg ccaattccta cgagaatgtg   1140

ctcatttgca agcagaaaac cacagagaca ggtgcccagc aggagggcat aggtggcctc   1200

tgcagagggg acctcagcct gtcactggcc ctgaagactg gccccacttc tggtctctgt   1260

ccctctgcct ccccggaaga agatgaggaa tctgaggatt atcagaactc agcatccatc   1320

catcagtggc gcgagtccag gaaggtcatg gggcaactcc agagagaagc atcccctggc   1380

ccggtgggaa gcccagacga ggaggacggg gaaccggatt acgtgaatgg ggaggtggca   1440

gccacagaag cctagggcag accaagaaga aaggagccaa ggcaaagagg gaccactgtg   1500

ctcatggacc catcgctgcc ttccaaggac catttcccag agctactcaa cttttaagcc   1560

cctgccatgg ttgctcctgg aaggagaacc agccaccctg aggaccacct ggccatgcgt   1620

gcacagcctg ggaaaagaca gttactcacg ggagctgcag gcccgtcacc aagccctctc   1680

ccgacccagg ctttgtgggg caggcacctg gtaccaaggg taacccggct cctggtatgg   1740

acggatgcgc aggatttagg ataagctgtc acccagtccc cataacaaaa ccactgtcca   1800

acactggtat ctgtgttctt ttgtgctatg aatttggatt cctaattgct attgttggtt   1860

gctggggttt taaatgattg ataagcttgt acagttaact tatagagggg gagccatatt   1920

taacattctg gatttcagag tagagatttc tgtgttgtct cctagaaagc attacatgta   1980

gtttatttca gcatccttgt tgggtggggc cctggctctc ttcccctttg gtgggacctc   2040

ccctttcttt gggcttcagt tcactcagga agaaatgagg ctgtcgccat ctttatgtgc   2100

ttccagtgga aatgtcactt gctacagaca atagtgcatg agagtctaga gaagtagtga   2160

ccagaacagg gcagagtagg tcccctccat ggccctgaat cctcctctgc tccagggctg   2220

gcctctgcag agctgattaa acagtgttgt gactgtctca tgggaagagc tggggcccag   2280

agggaccttg agtcagaaat gttgccagaa aaagtatctc ctccaaccaa aacatctcaa   2340

taaaaccatt ttagttgaaa agca                                          2364


<210>  3953
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  3953

Met Ser Ser Gly Thr Glu Leu Leu Trp Pro Gly Ala Ala Leu Leu Val 
1               5                   10                  15


Leu Leu Gly Val Ala Ala Ser Leu Cys Val Arg Cys Ser Arg Pro Gly 
            20                  25                  30


Ala Lys Arg Ser Glu Lys Ile Tyr Gln Gln Arg Ser Leu Arg Glu Asp 
        35                  40                  45


Gln Gln Ser Phe Thr Gly Ser Arg Thr Tyr Ser Leu Val Gly Gln Ala 
    50                  55                  60


Trp Pro Gly Pro Leu Ala Asp Met Ala Pro Thr Arg Lys Asp Lys Leu 
65                  70                  75                  80


Leu Gln Phe Tyr Pro Ser Leu Glu Asp Pro Ala Ser Ser Arg Tyr Gln 
                85                  90                  95


Asn Phe Ser Lys Gly Ser Arg His Gly Ser Glu Glu Ala Tyr Ile Asp 
            100                 105                 110


Pro Ile Ala Met Glu Tyr Tyr Asn Trp Gly Arg Phe Ser Lys Pro Pro 
        115                 120                 125


Glu Asp Asp Asp Ala Asn Ser Tyr Glu Asn Val Leu Ile Cys Lys Gln 
    130                 135                 140


Lys Thr Thr Glu Thr Gly Ala Gln Gln Glu Gly Ile Gly Gly Leu Cys 
145                 150                 155                 160


Arg Gly Asp Leu Ser Leu Ser Leu Ala Leu Lys Thr Gly Pro Thr Ser 
                165                 170                 175


Gly Leu Cys Pro Ser Ala Ser Pro Glu Glu Asp Glu Glu Ser Glu Asp 
            180                 185                 190


Tyr Gln Asn Ser Ala Ser Ile His Gln Trp Arg Glu Ser Arg Lys Val 
        195                 200                 205


Met Gly Gln Leu Gln Arg Glu Ala Ser Pro Gly Pro Val Gly Ser Pro 
    210                 215                 220


Asp Glu Glu Asp Gly Glu Pro Asp Tyr Val Asn Gly Glu Val Ala Ala 
225                 230                 235                 240


Thr Glu Ala 



<210>  3954
<211>  2483
<212>  DNA
<213>  Homo sapiens

<400>  3954
cattatcttg ctccctgtct attggagtgt atctctcttc ctctctgtgt gactttttgt     60

gtttatgtgt gtgtttagtg tgtgtccata ttttcctgtt ctcttgtgtc tctctgctgt    120

gtctctctct ttttctttct gttttttgag acggagtctc cctctgtcac ccaggctgga    180

gtgcagtggt gcgatctcgg ctcactgcaa cctctgcttc tgaggttcaa acgattctcc    240

tgcctcagcc tcccgagtag ctggaattac agacacatgc caccatgccc agctaatttt    300

gtatttttaa tagagacggg gtttcaccat gttggccagg ctggtcttaa actcttgacc    360

ttacgtgatc cacccgcctc ggcctcccaa agtttttgga ttacaggtgt gagccacctc    420

gcccggtcct atctctcttt cttctctttc tccctctcac tttgtttctc ttctctctct    480

ctctcccgcc tccttccccc gtctcccctc ccttcccccc accgccctct tcatagctga    540

gcctgtccgg cagtgcggcg gatgtacgga tgattcagtg gctggcagga agcccgccct    600

gcccgcccgc cagtgtcagt ggtgttggca tcagcttggg caggtgtgcg ggctcaggat    660

ggggcggccg tggtgaggaa ccctggactc tcagagatgg aatttcaccg tgttgcctag    720

gctggtctgg agctcttgat ctcaagcgat cctccctgcc tcggcctccc aacgtgctgg    780

gattataggc gtgagccacc gctcctggcc aggcatcaca agaggcaaca ccaggagcca    840

acatgagctc ggggactgaa ctgctgtggc ccggagcagc gctgctggtg ctgttggggg    900

tggcagccag tctgtgtgtg cgctgctcac gcccaggtgc aaagaggtca gagaaaatct    960

accagcagag aagtctgcgt gaggaccaac agagctttac ggggtcccgg acctactcct   1020

tggtcgggca ggcatggcca ggacccctgg cggacatggc acccacaagg aaggacaagc   1080

tgttgcaatt ctaccccagc ctggaggatc cagcatcttc caggtaccag aacttcagca   1140

aaggaagcag acacgggtcg gaggaagcct acatagaccc cattgccatg gagtattaca   1200

actgggggcg gttctcgaag cccccagaag atgatgatgc caattcctac gagaatgtgc   1260

tcatttgcaa gcagaaaacc acagagacag gtgcccagca ggagggcata ggtggcctct   1320

gcagagggga cctcagcctg tcactggccc tgaagactgg ccccacttct ggtctctgtc   1380

cctctgcctc cccggaagaa gatgaggaat ctgaggatta tcagaactca gcatccatcc   1440

atcagtggcg cgagtccagg aaggtcatgg ggcaactcca gagagaagca tcccctggcc   1500

cggtgggaag cccagacgag gaggacgggg aaccggatta cgtgaatggg gaggtggcag   1560

ccacagaagc ctagggcaga ccaagaagaa aggagccaag gcaaagaggg accactgtgc   1620

tcatggaccc atcgctgcct tccaaggacc atttcccaga gctactcaac ttttaagccc   1680

ctgccatggt tgctcctgga aggagaacca gccaccctga ggaccacctg gccatgcgtg   1740

cacagcctgg gaaaagacag ttactcacgg gagctgcagg cccgtcacca agccctctcc   1800

cgacccaggc tttgtggggc aggcacctgg taccaagggt aacccggctc ctggtatgga   1860

cggatgcgca ggatttagga taagctgtca cccagtcccc ataacaaaac cactgtccaa   1920

cactggtatc tgtgttcttt tgtgctatga atttggattc ctaattgcta ttgttggttg   1980

ctggggtttt aaatgattga taagcttgta cagttaactt atagaggggg agccatattt   2040

aacattctgg atttcagagt agagatttct gtgttgtctc ctagaaagca ttacatgtag   2100

tttatttcag catccttgtt gggtggggcc ctggctctct tcccctttgg tgggacctcc   2160

cctttctttg ggcttcagtt cactcaggaa gaaatgaggc tgtcgccatc tttatgtgct   2220

tccagtggaa atgtcacttg ctacagacaa tagtgcatga gagtctagag aagtagtgac   2280

cagaacaggg cagagtaggt cccctccatg gccctgaatc ctcctctgct ccagggctgg   2340

cctctgcaga gctgattaaa cagtgttgtg actgtctcat gggaagagct ggggcccaga   2400

gggaccttga gtcagaaatg ttgccagaaa aagtatctcc tccaaccaaa acatctcaat   2460

aaaaccattt tagttgaaaa gca                                           2483


<210>  3955
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  3955

Met Ser Ser Gly Thr Glu Leu Leu Trp Pro Gly Ala Ala Leu Leu Val 
1               5                   10                  15


Leu Leu Gly Val Ala Ala Ser Leu Cys Val Arg Cys Ser Arg Pro Gly 
            20                  25                  30


Ala Lys Arg Ser Glu Lys Ile Tyr Gln Gln Arg Ser Leu Arg Glu Asp 
        35                  40                  45


Gln Gln Ser Phe Thr Gly Ser Arg Thr Tyr Ser Leu Val Gly Gln Ala 
    50                  55                  60


Trp Pro Gly Pro Leu Ala Asp Met Ala Pro Thr Arg Lys Asp Lys Leu 
65                  70                  75                  80


Leu Gln Phe Tyr Pro Ser Leu Glu Asp Pro Ala Ser Ser Arg Tyr Gln 
                85                  90                  95


Asn Phe Ser Lys Gly Ser Arg His Gly Ser Glu Glu Ala Tyr Ile Asp 
            100                 105                 110


Pro Ile Ala Met Glu Tyr Tyr Asn Trp Gly Arg Phe Ser Lys Pro Pro 
        115                 120                 125


Glu Asp Asp Asp Ala Asn Ser Tyr Glu Asn Val Leu Ile Cys Lys Gln 
    130                 135                 140


Lys Thr Thr Glu Thr Gly Ala Gln Gln Glu Gly Ile Gly Gly Leu Cys 
145                 150                 155                 160


Arg Gly Asp Leu Ser Leu Ser Leu Ala Leu Lys Thr Gly Pro Thr Ser 
                165                 170                 175


Gly Leu Cys Pro Ser Ala Ser Pro Glu Glu Asp Glu Glu Ser Glu Asp 
            180                 185                 190


Tyr Gln Asn Ser Ala Ser Ile His Gln Trp Arg Glu Ser Arg Lys Val 
        195                 200                 205


Met Gly Gln Leu Gln Arg Glu Ala Ser Pro Gly Pro Val Gly Ser Pro 
    210                 215                 220


Asp Glu Glu Asp Gly Glu Pro Asp Tyr Val Asn Gly Glu Val Ala Ala 
225                 230                 235                 240


Thr Glu Ala 



<210>  3956
<211>  2307
<212>  DNA
<213>  Homo sapiens

<400>  3956
attatcttgc tccctgtcta ttggagtgta tctctcttcc tctctgtgtg actttttgtg     60

tttatgtgtg tgtttagtgt gtgtccatat tttcctgttc tcttgtgtct ctctgctgtg    120

tctctctctt tttctttctg ttttttgaga cggagtctcc ctctgtcacc caggctggag    180

tgcagtggtg cgatctcggc tcactgcaac ctctgcttct gaggttcaaa cgattctcct    240

gcctcagcct cccgagtagc tggaattaca gacacatgcc accatgccca gctaattttg    300

tatttttaat agagacgggg tttcaccatg ttggccaggc tggtcttaaa ctcttgacct    360

tacgtgatcc acccgcctcg gcctcccaaa gtttttggat tacaggtgtg agccacctcg    420

cccggtccta tctctctttc ttctctttct ccctctcact ttgtttctct tctctctctc    480

tctcccgcct ccttcccccg tctcccctcc cttcccccca ccgccctctt catagctgag    540

cctgtccggc agtgcggcgg atgtacggat gattcagtgg ctggcaggaa gcccgccctg    600

cccgcccgcc agtgtcagtg gtgttggcat cagcttgggc aggtgtgcgg gctcaggatg    660

gggcggccgt ggtgaggaac cctggactct cagcatcaca agaggcaaca ccaggagcca    720

acatgagctc ggggactgaa ctgctgtggc ccggagcagc gctgctggtg ctgttggggg    780

tggcagccag tctgtgtgtg cgctgctcac gcccaggtgc aaagaggtca gagaaaatct    840

accagcagag aagtctgcgt gaggaccaac agagctttac ggggtcccgg acctactcct    900

tggtcgggca ggcatggcca ggacccctgg cggacatggc acccacaagg aaggacaagc    960

tgttgcaatt ctaccccagc ctggaggatc cagcatcttc caggtaccag aacttcagca   1020

aaggaagcag acacgggtcg gaggaagcct acatatgatg atgccaattc ctacgagaat   1080

gtgctcattt gcaagcagaa aaccacagag acaggtgccc agcaggaggg cataggtggc   1140

ctctgcagag gggacctcag cctgtcactg gccctgaaga ctggccccac ttctggtctc   1200

tgtccctctg cctccccgga agaagatgag gaatctgagg attatcagaa ctcagcatcc   1260

atccatcagt ggcgcgagtc caggaaggtc atggggcaac tccagagaga agcatcccct   1320

ggcccggtgg gaagcccaga cgaggaggac ggggaaccgg attacgtgaa tggggaggtg   1380

gcagccacag aagcctaggg cagaccaaga agaaaggagc caaggcaaag agggaccact   1440

gtgctcatgg acccatcgct gccttccaag gaccatttcc cagagctact caacttttaa   1500

gcccctgcca tggttgctcc tggaaggaga accagccacc ctgaggacca cctggccatg   1560

cgtgcacagc ctgggaaaag acagttactc acgggagctg caggcccgtc accaagccct   1620

ctcccgaccc aggctttgtg gggcaggcac ctggtaccaa gggtaacccg gctcctggta   1680

tggacggatg cgcaggattt aggataagct gtcacccagt ccccataaca aaaccactgt   1740

ccaacactgg tatctgtgtt cttttgtgct atgaatttgg attcctaatt gctattgttg   1800

gttgctgggg ttttaaatga ttgataagct tgtacagtta acttatagag ggggagccat   1860

atttaacatt ctggatttca gagtagagat ttctgtgttg tctcctagaa agcattacat   1920

gtagtttatt tcagcatcct tgttgggtgg ggccctggct ctcttcccct ttggtgggac   1980

ctcccctttc tttgggcttc agttcactca ggaagaaatg aggctgtcgc catctttatg   2040

tgcttccagt ggaaatgtca cttgctacag acaatagtgc atgagagtct agagaagtag   2100

tgaccagaac agggcagagt aggtcccctc catggccctg aatcctcctc tgctccaggg   2160

ctggcctctg cagagctgat taaacagtgt tgtgactgtc tcatgggaag agctggggcc   2220

cagagggacc ttgagtcaga aatgttgcca gaaaaagtat ctcctccaac caaaacatct   2280

caataaaacc attttagttg aaaagca                                       2307


<210>  3957
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  3957

Met Ser Ser Gly Thr Glu Leu Leu Trp Pro Gly Ala Ala Leu Leu Val 
1               5                   10                  15


Leu Leu Gly Val Ala Ala Ser Leu Cys Val Arg Cys Ser Arg Pro Gly 
            20                  25                  30


Ala Lys Arg Ser Glu Lys Ile Tyr Gln Gln Arg Ser Leu Arg Glu Asp 
        35                  40                  45


Gln Gln Ser Phe Thr Gly Ser Arg Thr Tyr Ser Leu Val Gly Gln Ala 
    50                  55                  60


Trp Pro Gly Pro Leu Ala Asp Met Ala Pro Thr Arg Lys Asp Lys Leu 
65                  70                  75                  80


Leu Gln Phe Tyr Pro Ser Leu Glu Asp Pro Ala Ser Ser Arg Tyr Gln 
                85                  90                  95


Asn Phe Ser Lys Gly Ser Arg His Gly Ser Glu Glu Ala Tyr Ile 
            100                 105                 110


<210>  3958
<211>  1502
<212>  DNA
<213>  Homo sapiens

<400>  3958
ggggacaggg agcactgcaa aggctcagac acgggaaata gctggccctg ccttgggctg     60

cagcacccga gctgggtgca aagcaggggc caggggagaa agcaattagc tgggtctttc    120

ttccagatcc agcatcttcc aggtaccaga acttcagcaa aggaagcaga cacgggtcgg    180

aggaagccta catagacccc attgccatgg agtattacaa ctgggggcgg ttctcgaagc    240

ccccagaaga tgatgatgcc aattcctacg agaatgtgct catttgcaag cagaaaacca    300

cagagacagg tgcccagcag gagggcatag gtggcctctg cagaggggac ctcagcctgt    360

cactggccct gaagactggc cccacttctg gtctctgtcc ctctgcctcc ccggaagaag    420

atgaggaatc tgaggattat cagaactcag catccatcca tcagtggcgc gagtccagga    480

aggtcatggg gcaactccag agagaagcat cccctggccc ggtgggaagc ccagacgagg    540

aggacgggga accggattac gtgaatgggg aggtggcagc cacagaagcc tagggcagac    600

caagaagaaa ggagccaagg caaagaggga ccactgtgct catggaccca tcgctgcctt    660

ccaaggacca tttcccagag ctactcaact tttaagcccc tgccatggtt gctcctggaa    720

ggagaaccag ccaccctgag gaccacctgg ccatgcgtgc acagcctggg aaaagacagt    780

tactcacggg agctgcaggc ccgtcaccaa gccctctccc gacccaggct ttgtggggca    840

ggcacctggt accaagggta acccggctcc tggtatggac ggatgcgcag gatttaggat    900

aagctgtcac ccagtcccca taacaaaacc actgtccaac actggtatct gtgttctttt    960

gtgctatgaa tttggattcc taattgctat tgttggttgc tggggtttta aatgattgat   1020

aagcttgtac agttaactta tagaggggga gccatattta acattctgga tttcagagta   1080

gagatttctg tgttgtctcc tagaaagcat tacatgtagt ttatttcagc atccttgttg   1140

ggtggggccc tggctctctt cccctttggt gggacctccc ctttctttgg gcttcagttc   1200

actcaggaag aaatgaggct gtcgccatct ttatgtgctt ccagtggaaa tgtcacttgc   1260

tacagacaat agtgcatgag agtctagaga agtagtgacc agaacagggc agagtaggtc   1320

ccctccatgg ccctgaatcc tcctctgctc cagggctggc ctctgcagag ctgattaaac   1380

agtgttgtga ctgtctcatg ggaagagctg gggcccagag ggaccttgag tcagaaatgt   1440

tgccagaaaa agtatctcct ccaaccaaaa catctcaata aaaccatttt agttgaaaag   1500

ca                                                                  1502


<210>  3959
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  3959

Met Glu Tyr Tyr Asn Trp Gly Arg Phe Ser Lys Pro Pro Glu Asp Asp 
1               5                   10                  15


Asp Ala Asn Ser Tyr Glu Asn Val Leu Ile Cys Lys Gln Lys Thr Thr 
            20                  25                  30


Glu Thr Gly Ala Gln Gln Glu Gly Ile Gly Gly Leu Cys Arg Gly Asp 
        35                  40                  45


Leu Ser Leu Ser Leu Ala Leu Lys Thr Gly Pro Thr Ser Gly Leu Cys 
    50                  55                  60


Pro Ser Ala Ser Pro Glu Glu Asp Glu Glu Ser Glu Asp Tyr Gln Asn 
65                  70                  75                  80


Ser Ala Ser Ile His Gln Trp Arg Glu Ser Arg Lys Val Met Gly Gln 
                85                  90                  95


Leu Gln Arg Glu Ala Ser Pro Gly Pro Val Gly Ser Pro Asp Glu Glu 
            100                 105                 110


Asp Gly Glu Pro Asp Tyr Val Asn Gly Glu Val Ala Ala Thr Glu Ala 
        115                 120                 125


<210>  3960
<211>  738
<212>  DNA
<213>  Homo sapiens

<400>  3960
aaagagggac cactgtgctc atggacccat cgctgccttc caaggaccat ttcccagagc     60

tactcaactt ttaagcccct gccatggttg ctcctggaag gagaaccagc caccctgagg    120

accacctggc catgcgtgca cagcctggga aaagacagtt actcacggga gctgcaggcc    180

cgtcaccaag ccctctcccg acccaggctt tgtggggcag gcacctggta ccaagggtaa    240

cccggctcct ggtatggacg gatgcgcagg atttaggata agctgtcacc cagtccccat    300

aacaaaacca ctgtccaaca ctggtatctg tgttcttttg tgctatgaat ttggattcct    360

aattgctatt gttggttgct ggggttttaa atgattgata agcttgtaca gttaacttat    420

agagggggag ccatatttaa cattctggat ttcagagtag agatttctgt gttgtctcct    480

agaaagcatt acatgtagtt tatttcagca tccttgttgg gtggggccct ggctctcttc    540

ccctttggtg ggacgtcccc tccatggccc tgaatcctcc tctgctccag ggctggcctc    600

tgcagagctg attaaacagt gttgtgactg tctcatggga agagctgggg cccagaggga    660

ccttgagtca gaaatgttgc cagaaaaagt atctcctcca accaaaacat ctcaataaaa    720

ccattttagt tgaaaagc                                                  738


<210>  3961
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  3961

Met Val Ala Pro Gly Arg Arg Thr Ser His Pro Glu Asp His Leu Ala 
1               5                   10                  15


Met Arg Ala Gln Pro Gly Lys Arg Gln Leu Leu Thr Gly Ala Ala Gly 
            20                  25                  30


Pro Ser Pro Ser Pro Leu Pro Thr Gln Ala Leu Trp Gly Arg His Leu 
        35                  40                  45


Val Pro Arg Val Thr Arg Leu Leu Val Trp Thr Asp Ala Gln Asp Leu 
    50                  55                  60


Gly 
65


<210>  3962
<211>  162
<212>  DNA
<213>  Homo sapiens

<400>  3962
gtagtgacca gaacagggca gagtaggtcc cctccatggc cctgaatcct cctctgctcc     60

agggctggcc tctgcagagc tgattaaaca gtgttgtgac taaatgttgc cagaaaaagt    120

atctcctcca accaaaacat ctcaataaaa ccattttagt tg                       162


<210>  3963
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  3963

Pro Glu Gln Gly Arg Val Gly Pro Leu His Gly Pro Glu Ser Ser Ser 
1               5                   10                  15


Ala Pro Gly Leu Ala Ser Ala Glu Leu Ile Lys Gln Cys Cys Asp 
            20                  25                  30


<210>  3964
<211>  914
<212>  DNA
<213>  Homo sapiens

<400>  3964
tggtaaagga gatgatccag cactgtgtga atgccaacat tgacgaagcc tacaaggttg     60

gcctccttcc ccccgtcctg gcagaggaac cgctcacttc ttgggcagag gaaaaaaaaa    120

aaatatcatt ggcaacatct ttcgagtgtg taaaactttc caaatggcag aatacctgaa    180

actggagttt atcaaggaaa ttggatacac tcacatgaaa atagcggaag gagtgaactc    240

tcttttgcag atggcaggcc tcctggcaag gctgtgtcag aagacaatgg ccccggtggc    300

cagttagagc agagacttca ctgactgact tacaggtgcc ctattctgag gtacaggagc    360

cgcggctttc tgatggggga aaatgccgcc ttaggctgga gccaacatga ctgtccttta    420

aactccagtg gctggccagg cacggtagct cacgcctgta atcccaacac tttgggaggc    480

cgaggcaggt ggatcacctg aggtcagaag ttcaagacca gcctggccaa catggggaaa    540

ccctgtcttt actaaaaata taaaaattag ctgggtgtgg tggcgggcac ctgtaatccc    600

agctactcgg gaggctgtgg caggagaatc gcttgaaccc aggaggtgga ggttgcagtg    660

agccaagatc acaccattgc actccagcct gggcgacaga gtctccatct ggggaaaaaa    720

attaaataaa taaactcccg tgacttgcat gtttgcttct gggacgtctg tgccccgcaa    780

gtgtttgagt ttggcctcca ccccattgat gcggtgacgg ggcggaaagg cgcagagaag    840

ctgagggcgg tctctgatct gtgtgtgggt tgacatttta gctaataaag ccttgcagtg    900

tttgttggca ataa                                                      914


<210>  3965
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  3965

Met Ile Gln His Cys Val Asn Ala Asn Ile Asp Glu Ala Tyr Lys Val 
1               5                   10                  15


Gly Leu Leu Pro Pro Val Leu Ala Glu Glu Pro Leu Thr Ser Trp Ala 
            20                  25                  30


Glu Glu Lys Lys Lys Ile Ser Leu Ala Thr Ser Phe Glu Cys Val Lys 
        35                  40                  45


Leu Ser Lys Trp Gln Asn Thr 
    50                  55


<210>  3966
<211>  1602
<212>  DNA
<213>  Homo sapiens

<400>  3966
cgagaatgga ggtggaggcc gtctgtggtg gcgcgggcga ggtggaggcc caggactctg     60

accctgcccc tgccttcagc aaggcccccg gcagcgccgg ccactacgaa ctgccgtggt    120

ctttgcaagg gaaggaaatg tgcccaacat catcattgcg ggccctccag gaaccggcaa    180

gaccacaagc attctgtgct tggcccgggc cctgctgggc ccagcactca aagatgccat    240

gttggaactc aatgcttcaa atgacagggg cattgacgtt gtgaggaata aaattaaaat    300

gtttgctcaa caaaaagtca ctcttcccaa aggccgacat aagatcatca ttctggatga    360

agcagacagc atgaccgacg gagcccagca agccttgagg agaaccatgg aaatctactc    420

taaaaccact cgcttcgccc ttgcttgtaa tgcttcggat aagatcatcg agcccattca    480

gtcccgctgt gcagtcctcc ggtacacaaa gctgaccgac gcccagatcc tcaccaggct    540

gatgaatgtt atcgagaagg agagggtacc ctacactgat gacggcctag aagccatcat    600

cttcacggcc cagggagaca tgaggcaggc gctgaacaac ctgcagtcca ccttctcagg    660

atttggcttc attaacagtg agaacgtgtt caaggtctgt gacgagcccc acccactgct    720

ggtaaaggag atgatccagc actgtgtgaa tgccaacatt gacgaagcct acaagattct    780

tgctcacttg tggcatctgg gctactcacc agaagatatc attggcaaca tctttcgagt    840

gtgtaaaact ttccaaatgg cagaatacct gaaactggag tttatcaagg aaattggata    900

cactcacatg aaaatagcgg aaggagtgaa ctctcttttg cagatggcag gcctcctggc    960

aaggctgtgt cagaagacaa tggccccggt ggccagttag agcagagact tcactgactg   1020

acttacaggt gccctattct gaggtacagg agccgcggct ttctgatggg ggaaaatgcc   1080

gccttaggct ggagccaaca tgactgtcct ttaaactcca gtggctggcc aggcacggta   1140

gctcacgcct gtaatcccaa cactttggga ggccgaggca ggtggatcac ctgaggtcag   1200

aagttcaaga ccagcctggc caacatgggg aaaccctgtc tttactaaaa atataaaaat   1260

tagctgggtg tggtggcggg cacctgtaat cccagctact cgggaggctg tggcaggaga   1320

atcgcttgaa cccaggaggt ggaggttgca gtgagccaag atcacaccat tgcactccag   1380

cctgggcgac agagtctcca tctggggaaa aaaattaaat aaataaactc ccgtgacttg   1440

catgtttgct tctgggacgt ctgtgccccg caagtgtttg agtttggcct ccaccccatt   1500

gatgcggtga cggggcggaa aggcgcagag aagctgaggg cggtctctga tctgtgtgtg   1560

ggttgacatt ttagctaata aagccttgca gtgtttgttg gc                      1602


<210>  3967
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  3967

Met Leu Glu Leu Asn Ala Ser Asn Asp Arg Gly Ile Asp Val Val Arg 
1               5                   10                  15


Asn Lys Ile Lys Met Phe Ala Gln Gln Lys Val Thr Leu Pro Lys Gly 
            20                  25                  30


Arg His Lys Ile Ile Ile Leu Asp Glu Ala Asp Ser Met Thr Asp Gly 
        35                  40                  45


Ala Gln Gln Ala Leu Arg Arg Thr Met Glu Ile Tyr Ser Lys Thr Thr 
    50                  55                  60


Arg Phe Ala Leu Ala Cys Asn Ala Ser Asp Lys Ile Ile Glu Pro Ile 
65                  70                  75                  80


Gln Ser Arg Cys Ala Val Leu Arg Tyr Thr Lys Leu Thr Asp Ala Gln 
                85                  90                  95


Ile Leu Thr Arg Leu Met Asn Val Ile Glu Lys Glu Arg Val Pro Tyr 
            100                 105                 110


Thr Asp Asp Gly Leu Glu Ala Ile Ile Phe Thr Ala Gln Gly Asp Met 
        115                 120                 125


Arg Gln Ala Leu Asn Asn Leu Gln Ser Thr Phe Ser Gly Phe Gly Phe 
    130                 135                 140


Ile Asn Ser Glu Asn Val Phe Lys Val Cys Asp Glu Pro His Pro Leu 
145                 150                 155                 160


Leu Val Lys Glu Met Ile Gln His Cys Val Asn Ala Asn Ile Asp Glu 
                165                 170                 175


Ala Tyr Lys Ile Leu Ala His Leu Trp His Leu Gly Tyr Ser Pro Glu 
            180                 185                 190


Asp Ile Ile Gly Asn Ile Phe Arg Val Cys Lys Thr Phe Gln Met Ala 
        195                 200                 205


Glu Tyr Leu Lys Leu Glu Phe Ile Lys Glu Ile Gly Tyr Thr His Met 
    210                 215                 220


Lys Ile Ala Glu Gly Val Asn Ser Leu Leu Gln Met Ala Gly Leu Leu 
225                 230                 235                 240


Ala Arg Leu Cys Gln Lys Thr Met Ala Pro Val Ala Ser 
                245                 250


<210>  3968
<211>  1694
<212>  DNA
<213>  Homo sapiens

<400>  3968
gcgagaatgg aggtggaggc cgtctgtggt ggcgcgggcg aggtggaggc ccaggactct     60

gaccctgccc ctgccttcag caaggccccc ggcagcgccg gccactacga actgccgtga    120

tggagtcaca ctttgtcaca caggctggag tgcagtggtg tgatttctgc tcactacaac    180

ctgcatctcc ctggttcaat caattctgcc tcagccttcc tagtagctgg gattacaggc    240

atggttgaaa aatataggcc agtaaagctg aatgaaattg tcgggaatga agacaccgtg    300

agcaggctag aggtctttgc aagggaagga aatgtgccca acatcatcat tgcgggccct    360

ccaggaaccg gcaagaccac aagcattctg tgcttggccc gggccctgct gggcccagca    420

ctcaaagatg ccatgttgga actcaatgct tcaaatgaca gcatgaccga cggagcccag    480

caagccttga ggagaaccat ggaaatctac tctaaaacca ctcgcttcgc ccttgcttgt    540

aatgcttcgg ataagatcat cgagcccatt cagtcccgct gtgcagtcct ccggtacaca    600

aagctgaccg acgcccagat cctcaccagg ctgatgaatg ttatcgagaa ggagagggta    660

ccctacactg atgacggcct agaagccatc atcttcacgg cccagggaga catgaggcag    720

gcgctgaaca acctgcagtc caccttctca ggatttggct tcattaacag tgagaacgtg    780

ttcaaggtct gtgacgagcc ccacccactg ctggtaaagg agatgatcca gcactgtgtg    840

aatgccaaca ttgacgaagc ctacaagatt cttgctcact tgtggcatct gggctactca    900

ccagaagata tcattggcaa catctttcga gtgtgtaaaa ctttccaaat ggcagaatac    960

ctgaaactgg agtttatcaa ggaaattgga tacactcaca tgaaaatagc ggaaggagtg   1020

aactctcttt tgcagatggc aggcctcctg gcaaggctgt gtcagaagac aatggccccg   1080

gtggccagtt agagcagaga cttcactgac tgacttacag gtgccctatt ctgaggtaca   1140

ggagccgcgg ctttctgatg ggggaaaatg ccgccttagg ctggagccaa catgactgtc   1200

ctttaaactc cagtggctgg ccaggcacgg tagctcacgc ctgtaatccc aacactttgg   1260

gaggccgagg caggtggatc acctgaggtc agaagttcaa gaccagcctg gccaacatgg   1320

ggaaaccctg tctttactaa aaatataaaa attagctggg tgtggtggcg ggcacctgta   1380

atcccagcta ctcgggaggc tgtggcagga gaatcgcttg aacccaggag gtggaggttg   1440

cagtgagcca agatcacacc attgcactcc agcctgggcg acagagtctc catctgggga   1500

aaaaaattaa ataaataaac tcccgtgact tgcatgtttg cttctgggac gtctgtgccc   1560

cgcaagtgtt tgagtttggc ctccacccca ttgatgcggt gacggggcgg aaaggcgcag   1620

agaagctgag ggcggtctct gatctgtgtg tgggttgaca ttttagctaa taaagccttg   1680

cagtgtttgt tggc                                                     1694


<210>  3969
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  3969

Met Val Glu Lys Tyr Arg Pro Val Lys Leu Asn Glu Ile Val Gly Asn 
1               5                   10                  15


Glu Asp Thr Val Ser Arg Leu Glu Val Phe Ala Arg Glu Gly Asn Val 
            20                  25                  30


Pro Asn Ile Ile Ile Ala Gly Pro Pro Gly Thr Gly Lys Thr Thr Ser 
        35                  40                  45


Ile Leu Cys Leu Ala Arg Ala Leu Leu Gly Pro Ala Leu Lys Asp Ala 
    50                  55                  60


Met Leu Glu Leu Asn Ala Ser Asn Asp Ser Met Thr Asp Gly Ala Gln 
65                  70                  75                  80


Gln Ala Leu Arg Arg Thr Met Glu Ile Tyr Ser Lys Thr Thr Arg Phe 
                85                  90                  95


Ala Leu Ala Cys Asn Ala Ser Asp Lys Ile Ile Glu Pro Ile Gln Ser 
            100                 105                 110


Arg Cys Ala Val Leu Arg Tyr Thr Lys Leu Thr Asp Ala Gln Ile Leu 
        115                 120                 125


Thr Arg Leu Met Asn Val Ile Glu Lys Glu Arg Val Pro Tyr Thr Asp 
    130                 135                 140


Asp Gly Leu Glu Ala Ile Ile Phe Thr Ala Gln Gly Asp Met Arg Gln 
145                 150                 155                 160


Ala Leu Asn Asn Leu Gln Ser Thr Phe Ser Gly Phe Gly Phe Ile Asn 
                165                 170                 175


Ser Glu Asn Val Phe Lys Val Cys Asp Glu Pro His Pro Leu Leu Val 
            180                 185                 190


Lys Glu Met Ile Gln His Cys Val Asn Ala Asn Ile Asp Glu Ala Tyr 
        195                 200                 205


Lys Ile Leu Ala His Leu Trp His Leu Gly Tyr Ser Pro Glu Asp Ile 
    210                 215                 220


Ile Gly Asn Ile Phe Arg Val Cys Lys Thr Phe Gln Met Ala Glu Tyr 
225                 230                 235                 240


Leu Lys Leu Glu Phe Ile Lys Glu Ile Gly Tyr Thr His Met Lys Ile 
                245                 250                 255


Ala Glu Gly Val Asn Ser Leu Leu Gln Met Ala Gly Leu Leu Ala Arg 
            260                 265                 270


Leu Cys Gln Lys Thr Met Ala Pro Val Ala Ser 
        275                 280


<210>  3970
<211>  1606
<212>  DNA
<213>  Homo sapiens

<400>  3970
aaggggcggt gcctcgggtg gcgggaagag gaggcgcgag aatggaggtg gaggccgtct     60

gtggtggcgc gggcgaggtg gaggcccagg actctgaccc tgcccctgcc ttcagcaagg    120

cccccggcag cgccggccac tacgaactgc cgtgggttga aaaatatagg ccagtaaagc    180

tgaatgaaat tgtcgggaat gaagacaccg tgagcaggct agaggtcttt gcaagggaag    240

gaaatgtgcc caacatcatc attgcgggcc ctccaggaac cggcaagacc acaagcattc    300

tgtgcttggc ccgggccctg ctgggcccag cactcaaaga tgccatgttg gaactcaatg    360

cttcaaatga cagcatgacc gacggagccc agcaagcctt gaggagaacc atggaaatct    420

actctaaaac cactcgcttc gcccttgctt gtaatgcttc ggataagatc atcgagccca    480

ttcagtcccg ctgtgcagtc ctccggtaca caaagctgac cgacgcccag atcctcacca    540

ggctgatgaa tgttatcgag aaggagaggg taccctacac tgatgacggc ctagaagcca    600

tcatcttcac ggcccaggga gacatgaggc aggcgctgaa caacctgcag tccaccttct    660

caggatttgg cttcattaac agtgagaacg tgttcaaggt ctgtgacgag ccccacccac    720

tgctggtaaa ggagatgatc cagcactgtg tgaatgccaa cattgacgaa gcctacaaga    780

ttcttgctca cttgtggcat ctgggctact caccagaaga tatcattggc aacatctttc    840

gagtgtgtaa aactttccaa atggcagaat acctgaaact ggagtttatc aaggaaattg    900

gatacactca catgaaaata gcggaaggag tgaactctct tttgcagatg gcaggcctcc    960

tggcaaggct gtgtcagaag acaatggccc cggtggccag ttagagcaga gacttcactg   1020

actgacttac aggtgcccta ttctgaggta caggagccgc ggctttctga tgggggaaaa   1080

tgccgcctta ggctggagcc aacatgactg tcctttaaac tccagtggct ggccaggcac   1140

ggtagctcac gcctgtaatc ccaacacttt gggaggccga ggcaggtgga tcacctgagg   1200

tcagaagttc aagaccagcc tggccaacat ggggaaaccc tgtctttact aaaaatataa   1260

aaattagctg ggtgtggtgg cgggcacctg taatcccagc tactcgggag gctgtggcag   1320

gagaatcgct tgaacccagg aggtggaggt tgcagtgagc caagatcaca ccattgcact   1380

ccagcctggg cgacagagtc tccatctggg gaaaaaaatt aaataaataa actcccgtga   1440

cttgcatgtt tgcttctggg acgtctgtgc cccgcaagtg tttgagtttg gcctccaccc   1500

cattgatgcg gtgacggggc ggaaaggcgc agagaagctg agggcggtct ctgatctgtg   1560

tgtgggttga cattttagct aataaagcct tgcagtgttt gttggc                  1606


<210>  3971
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  3971

Met Glu Val Glu Ala Val Cys Gly Gly Ala Gly Glu Val Glu Ala Gln 
1               5                   10                  15


Asp Ser Asp Pro Ala Pro Ala Phe Ser Lys Ala Pro Gly Ser Ala Gly 
            20                  25                  30


His Tyr Glu Leu Pro Trp Val Glu Lys Tyr Arg Pro Val Lys Leu Asn 
        35                  40                  45


Glu Ile Val Gly Asn Glu Asp Thr Val Ser Arg Leu Glu Val Phe Ala 
    50                  55                  60


Arg Glu Gly Asn Val Pro Asn Ile Ile Ile Ala Gly Pro Pro Gly Thr 
65                  70                  75                  80


Gly Lys Thr Thr Ser Ile Leu Cys Leu Ala Arg Ala Leu Leu Gly Pro 
                85                  90                  95


Ala Leu Lys Asp Ala Met Leu Glu Leu Asn Ala Ser Asn Asp Ser Met 
            100                 105                 110


Thr Asp Gly Ala Gln Gln Ala Leu Arg Arg Thr Met Glu Ile Tyr Ser 
        115                 120                 125


Lys Thr Thr Arg Phe Ala Leu Ala Cys Asn Ala Ser Asp Lys Ile Ile 
    130                 135                 140


Glu Pro Ile Gln Ser Arg Cys Ala Val Leu Arg Tyr Thr Lys Leu Thr 
145                 150                 155                 160


Asp Ala Gln Ile Leu Thr Arg Leu Met Asn Val Ile Glu Lys Glu Arg 
                165                 170                 175


Val Pro Tyr Thr Asp Asp Gly Leu Glu Ala Ile Ile Phe Thr Ala Gln 
            180                 185                 190


Gly Asp Met Arg Gln Ala Leu Asn Asn Leu Gln Ser Thr Phe Ser Gly 
        195                 200                 205


Phe Gly Phe Ile Asn Ser Glu Asn Val Phe Lys Val Cys Asp Glu Pro 
    210                 215                 220


His Pro Leu Leu Val Lys Glu Met Ile Gln His Cys Val Asn Ala Asn 
225                 230                 235                 240


Ile Asp Glu Ala Tyr Lys Ile Leu Ala His Leu Trp His Leu Gly Tyr 
                245                 250                 255


Ser Pro Glu Asp Ile Ile Gly Asn Ile Phe Arg Val Cys Lys Thr Phe 
            260                 265                 270


Gln Met Ala Glu Tyr Leu Lys Leu Glu Phe Ile Lys Glu Ile Gly Tyr 
        275                 280                 285


Thr His Met Lys Ile Ala Glu Gly Val Asn Ser Leu Leu Gln Met Ala 
    290                 295                 300


Gly Leu Leu Ala Arg Leu Cys Gln Lys Thr Met Ala Pro Val Ala Ser 
305                 310                 315                 320


<210>  3972
<211>  1714
<212>  DNA
<213>  Homo sapiens

<400>  3972
ggcgtcaagg ggcggtgcct cgggtggcgg gaagaggagg cgcgagaatg gaggtggagg     60

ccgtctgtgg tggcgcgggc gaggtggagg cccaggactc tgaccctgcc cctgccttca    120

gcaaggcccc cggcagcgcc ggccactacg aactgccgtg ggttgaaaaa tataggccag    180

taaagctgaa tgaaattgtc gggaatgaag acaccgtgag caggctagag gtctttgcaa    240

gggaaggaaa tgtgcccaac atcatcattg cgggccctcc aggaaccggc aagaccacaa    300

gcattctgtg cttggcccgg gccctgctgg gcccagcact caaagatgcc atgttggaac    360

tcaatgcttc aaatgacagg ggcattgacg ttgtgaggaa taaaattaaa atgtttgctc    420

aacaaaaagt cactcttccc aaaggccgac ataagatcat cattctggat gaagcagaca    480

gcatgaccga cggagcccag caagccttga ggagaaccat ggaaatctac tctaaaacca    540

ctcgcttcgc ccttgcttgt aatgcttcgg ataagatcat cgagcccatt cagtcccgct    600

gtgcagtcct ccggtacaca aagctgaccg acgcccagat cctcaccagg ctgatgaatg    660

ttatcgagaa ggagagggta ccctacactg atgacggcct agaagccatc atcttcacgg    720

cccagggaga catgaggcag gcgctgaaca acctgcagtc caccttctca ggatttggct    780

tcattaacag tgagaacgtg ttcaaggtct gtgacgagcc ccacccactg ctggtaaagg    840

agatgatcca gcactgtgtg aatgccaaca ttgacgaagc ctacaagatt cttgctcact    900

tgtggcatct gggctactca ccagaagata tcattggcaa catctttcga gtgtgtaaaa    960

ctttccaaat ggcagaatac ctgaaactgg agtttatcaa ggaaattgga tacactcaca   1020

tgaaaatagc ggaaggagtg aactctcttt tgcagatggc aggcctcctg gcaaggctgt   1080

gtcagaagac aatggccccg gtggccagtt agagcagaga cttcactgac tgacttacag   1140

gtgccctatt ctgaggtaca ggagccgcgg ctttctgatg ggggaaaatg ccgccttagg   1200

ctggagccaa catgactgtc ctttaaactc cagtggctgg ccaggcacgg tagctcacgc   1260

ctgtaatccc aacactttgg gaggccgagg caggtggatc acctgaggtc agaagttcaa   1320

gaccagcctg gccaacatgg ggaaaccctg tctttactaa aaatataaaa attagctggg   1380

tgtggtggcg ggcacctgta atcccagcta ctcgggaggc tgtggcagga gaatcgcttg   1440

aacccaggag gtggaggttg cagtgagcca agatcacacc attgcactcc agcctgggcg   1500

acagagtctc catctgggga aaaaaattaa ataaataaac tcccgtgact tgcatgtttg   1560

cttctgggac gtctgtgccc cgcaagtgtt tgagtttggc ctccacccca ttgatgcggt   1620

gacggggcgg aaaggcgcag agaagctgag ggcggtctct gatctgtgtg tgggttgaca   1680

ttttagctaa taaagccttg cagtgtttgt tggc                               1714


<210>  3973
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  3973

Met Glu Val Glu Ala Val Cys Gly Gly Ala Gly Glu Val Glu Ala Gln 
1               5                   10                  15


Asp Ser Asp Pro Ala Pro Ala Phe Ser Lys Ala Pro Gly Ser Ala Gly 
            20                  25                  30


His Tyr Glu Leu Pro Trp Val Glu Lys Tyr Arg Pro Val Lys Leu Asn 
        35                  40                  45


Glu Ile Val Gly Asn Glu Asp Thr Val Ser Arg Leu Glu Val Phe Ala 
    50                  55                  60


Arg Glu Gly Asn Val Pro Asn Ile Ile Ile Ala Gly Pro Pro Gly Thr 
65                  70                  75                  80


Gly Lys Thr Thr Ser Ile Leu Cys Leu Ala Arg Ala Leu Leu Gly Pro 
                85                  90                  95


Ala Leu Lys Asp Ala Met Leu Glu Leu Asn Ala Ser Asn Asp Arg Gly 
            100                 105                 110


Ile Asp Val Val Arg Asn Lys Ile Lys Met Phe Ala Gln Gln Lys Val 
        115                 120                 125


Thr Leu Pro Lys Gly Arg His Lys Ile Ile Ile Leu Asp Glu Ala Asp 
    130                 135                 140


Ser Met Thr Asp Gly Ala Gln Gln Ala Leu Arg Arg Thr Met Glu Ile 
145                 150                 155                 160


Tyr Ser Lys Thr Thr Arg Phe Ala Leu Ala Cys Asn Ala Ser Asp Lys 
                165                 170                 175


Ile Ile Glu Pro Ile Gln Ser Arg Cys Ala Val Leu Arg Tyr Thr Lys 
            180                 185                 190


Leu Thr Asp Ala Gln Ile Leu Thr Arg Leu Met Asn Val Ile Glu Lys 
        195                 200                 205


Glu Arg Val Pro Tyr Thr Asp Asp Gly Leu Glu Ala Ile Ile Phe Thr 
    210                 215                 220


Ala Gln Gly Asp Met Arg Gln Ala Leu Asn Asn Leu Gln Ser Thr Phe 
225                 230                 235                 240


Ser Gly Phe Gly Phe Ile Asn Ser Glu Asn Val Phe Lys Val Cys Asp 
                245                 250                 255


Glu Pro His Pro Leu Leu Val Lys Glu Met Ile Gln His Cys Val Asn 
            260                 265                 270


Ala Asn Ile Asp Glu Ala Tyr Lys Ile Leu Ala His Leu Trp His Leu 
        275                 280                 285


Gly Tyr Ser Pro Glu Asp Ile Ile Gly Asn Ile Phe Arg Val Cys Lys 
    290                 295                 300


Thr Phe Gln Met Ala Glu Tyr Leu Lys Leu Glu Phe Ile Lys Glu Ile 
305                 310                 315                 320


Gly Tyr Thr His Met Lys Ile Ala Glu Gly Val Asn Ser Leu Leu Gln 
                325                 330                 335


Met Ala Gly Leu Leu Ala Arg Leu Cys Gln Lys Thr Met Ala Pro Val 
            340                 345                 350


Ala Ser 



<210>  3974
<211>  748
<212>  DNA
<213>  Homo sapiens

<400>  3974
tggtaaagga gatgatccag cactgtgtga atgccaacat tgacgaagcc tacaaggttg     60

gcctccttcc ccccgtcctg gcagaggaac cgctcacttc ttgggcagag gaaaaaaaaa    120

aaatatcatt ggcaacatct ttcgagtgtg taaaactttc caaatggcag aatacctgaa    180

actggagttt atcaaggaaa ttggatacac tcacatgaaa atagcggaag gagtgaactc    240

tcttttgcag atggcaggcc tcctggcaag gctgtgtcag aagacaatgg ccccggtggc    300

cagttagagc agagacttca ctgactgact tacaggtgcc ctattctgag gtacaggagc    360

cgcggctttc tgatggggga aaatgccgcc ttaggctgga gccaacatga ctgtccttta    420

aactccagtg gctggccagg cacggtagct cacgcctgta atcccaacac tttgggaggc    480

cgaggcaggt ggatcacctg aggtcagaag ttcaagacca gcctggccaa catggggaaa    540

ccctgtcttt actaaaaata taaaaattag ctgggtgtgg tggcgggcac ctgtaatccc    600

agctactcgg gaggctgtgg caggagaatc gcttgaaccc aggaggtgga ggttgcagtg    660

agccaagatc acaccattgc actccagcct gggcgacaga gtctccatct ggggaaaaaa    720

attaaataaa taaactcccg tgacttgc                                       748


<210>  3975
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  3975

Met Ile Gln His Cys Val Asn Ala Asn Ile Asp Glu Ala Tyr Lys Val 
1               5                   10                  15


Gly Leu Leu Pro Pro Val Leu Ala Glu Glu Pro Leu Thr Ser Trp Ala 
            20                  25                  30


Glu Glu Lys Lys Lys Ile Ser Leu Ala Thr Ser Phe Glu Cys Val Lys 
        35                  40                  45


Leu Ser Lys Trp Gln Asn Thr 
    50                  55


<210>  3976
<211>  1533
<212>  DNA
<213>  Homo sapiens

<400>  3976
gcgagaatgg aggtggaggc cgtctgtggt ggcgcgggcg aggtggaggc ccaggactct     60

gaccctgccc ctgccttcag caaggccccc ggcagcgccg gccactacga actgccgtga    120

tggagtcaca ctttgtcaca caggctggag tgcagtggtg tgatttctgc tcactacaac    180

ctgcatctcc ctggttcaat caattctgcc tcagccttcc tagtagctgg gattacaggc    240

atggttgaaa aatataggcc agtaaagctg aatgaaattg tcgggaatga agacaccgtg    300

agcaggctag aggtctttgc aagggaagga aatgtgccca acatcatcat tgcgggccct    360

ccaggaaccg gcaagaccac aagcattctg tgcttggccc gggccctgct gggcccagca    420

ctcaaagatg ccatgttgga actcaatgct tcaaatgaca gcatgaccga cggagcccag    480

caagccttga ggagaaccat ggaaatctac tctaaaacca ctcgcttcgc ccttgcttgt    540

aatgcttcgg ataagatcat cgagcccatt cagtcccgct gtgcagtcct ccggtacaca    600

aagctgaccg acgcccagat cctcaccagg ctgatgaatg ttatcgagaa ggagagggta    660

ccctacactg atgacggcct agaagccatc atcttcacgg cccagggaga catgaggcag    720

gcgctgaaca acctgcagtc caccttctca ggatttggct tcattaacag tgagaacgtg    780

ttcaaggtct gtgacgagcc ccacccactg ctggtaaagg agatgatcca gcactgtgtg    840

aatgccaaca ttgacgaagc ctacaagatt cttgctcact tgtggcatct gggctactca    900

ccagaagata tcattggcaa catctttcga gtgtgtaaaa ctttccaaat ggcagaatac    960

ctgaaactgg agtttatcaa ggaaattgga tacactcaca tgaaaatagc ggaaggagtg   1020

aactctcttt tgcagatggc aggcctcctg gcaaggctgt gtcagaagac aatggccccg   1080

gtggccagtt agagcagaga cttcactgac tgacttacag gtgccctatt ctgaggtaca   1140

ggagccgcgg ctttctgatg ggggaaaatg ccgccttagg ctggagccaa catgactgtc   1200

ctttaaactc cagtggctgg ccaggcacgg tagctcacgc ctgtaatccc aacactttgg   1260

gaggccgagg caggtggatc acctgaggtc agaagttcaa gaccagcctg gccaacatgg   1320

ggaaaccctg tctttactaa aaatataaaa attagctggg tgtggtggcg ggcacctgta   1380

atcccagcta ctcgggaggc tgtggcagga gaatcgcttg aacccaggag gtggaggttg   1440

cagtgagcca agatcacacc attgcactcc agcctgggcg acagagtctc catctgggga   1500

aaaaaattaa ataaataaac tcccgtgact tgc                                1533


<210>  3977
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  3977

Met Val Glu Lys Tyr Arg Pro Val Lys Leu Asn Glu Ile Val Gly Asn 
1               5                   10                  15


Glu Asp Thr Val Ser Arg Leu Glu Val Phe Ala Arg Glu Gly Asn Val 
            20                  25                  30


Pro Asn Ile Ile Ile Ala Gly Pro Pro Gly Thr Gly Lys Thr Thr Ser 
        35                  40                  45


Ile Leu Cys Leu Ala Arg Ala Leu Leu Gly Pro Ala Leu Lys Asp Ala 
    50                  55                  60


Met Leu Glu Leu Asn Ala Ser Asn Asp Ser Met Thr Asp Gly Ala Gln 
65                  70                  75                  80


Gln Ala Leu Arg Arg Thr Met Glu Ile Tyr Ser Lys Thr Thr Arg Phe 
                85                  90                  95


Ala Leu Ala Cys Asn Ala Ser Asp Lys Ile Ile Glu Pro Ile Gln Ser 
            100                 105                 110


Arg Cys Ala Val Leu Arg Tyr Thr Lys Leu Thr Asp Ala Gln Ile Leu 
        115                 120                 125


Thr Arg Leu Met Asn Val Ile Glu Lys Glu Arg Val Pro Tyr Thr Asp 
    130                 135                 140


Asp Gly Leu Glu Ala Ile Ile Phe Thr Ala Gln Gly Asp Met Arg Gln 
145                 150                 155                 160


Ala Leu Asn Asn Leu Gln Ser Thr Phe Ser Gly Phe Gly Phe Ile Asn 
                165                 170                 175


Ser Glu Asn Val Phe Lys Val Cys Asp Glu Pro His Pro Leu Leu Val 
            180                 185                 190


Lys Glu Met Ile Gln His Cys Val Asn Ala Asn Ile Asp Glu Ala Tyr 
        195                 200                 205


Lys Ile Leu Ala His Leu Trp His Leu Gly Tyr Ser Pro Glu Asp Ile 
    210                 215                 220


Ile Gly Asn Ile Phe Arg Val Cys Lys Thr Phe Gln Met Ala Glu Tyr 
225                 230                 235                 240


Leu Lys Leu Glu Phe Ile Lys Glu Ile Gly Tyr Thr His Met Lys Ile 
                245                 250                 255


Ala Glu Gly Val Asn Ser Leu Leu Gln Met Ala Gly Leu Leu Ala Arg 
            260                 265                 270


Leu Cys Gln Lys Thr Met Ala Pro Val Ala Ser 
        275                 280


<210>  3978
<211>  1445
<212>  DNA
<213>  Homo sapiens

<400>  3978
aaggggcggt gcctcgggtg gcgggaagag gaggcgcgag aatggaggtg gaggccgtct     60

gtggtggcgc gggcgaggtg gaggcccagg actctgaccc tgcccctgcc ttcagcaagg    120

cccccggcag cgccggccac tacgaactgc cgtgggttga aaaatatagg ccagtaaagc    180

tgaatgaaat tgtcgggaat gaagacaccg tgagcaggct agaggtcttt gcaagggaag    240

gaaatgtgcc caacatcatc attgcgggcc ctccaggaac cggcaagacc acaagcattc    300

tgtgcttggc ccgggccctg ctgggcccag cactcaaaga tgccatgttg gaactcaatg    360

cttcaaatga cagcatgacc gacggagccc agcaagcctt gaggagaacc atggaaatct    420

actctaaaac cactcgcttc gcccttgctt gtaatgcttc ggataagatc atcgagccca    480

ttcagtcccg ctgtgcagtc ctccggtaca caaagctgac cgacgcccag atcctcacca    540

ggctgatgaa tgttatcgag aaggagaggg taccctacac tgatgacggc ctagaagcca    600

tcatcttcac ggcccaggga gacatgaggc aggcgctgaa caacctgcag tccaccttct    660

caggatttgg cttcattaac agtgagaacg tgttcaaggt ctgtgacgag ccccacccac    720

tgctggtaaa ggagatgatc cagcactgtg tgaatgccaa cattgacgaa gcctacaaga    780

ttcttgctca cttgtggcat ctgggctact caccagaaga tatcattggc aacatctttc    840

gagtgtgtaa aactttccaa atggcagaat acctgaaact ggagtttatc aaggaaattg    900

gatacactca catgaaaata gcggaaggag tgaactctct tttgcagatg gcaggcctcc    960

tggcaaggct gtgtcagaag acaatggccc cggtggccag ttagagcaga gacttcactg   1020

actgacttac aggtgcccta ttctgaggta caggagccgc ggctttctga tgggggaaaa   1080

tgccgcctta ggctggagcc aacatgactg tcctttaaac tccagtggct ggccaggcac   1140

ggtagctcac gcctgtaatc ccaacacttt gggaggccga ggcaggtgga tcacctgagg   1200

tcagaagttc aagaccagcc tggccaacat ggggaaaccc tgtctttact aaaaatataa   1260

aaattagctg ggtgtggtgg cgggcacctg taatcccagc tactcgggag gctgtggcag   1320

gagaatcgct tgaacccagg aggtggaggt tgcagtgagc caagatcaca ccattgcact   1380

ccagcctggg cgacagagtc tccatctggg gaaaaaaatt aaataaataa actcccgtga   1440

cttgc                                                               1445


<210>  3979
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  3979

Met Glu Val Glu Ala Val Cys Gly Gly Ala Gly Glu Val Glu Ala Gln 
1               5                   10                  15


Asp Ser Asp Pro Ala Pro Ala Phe Ser Lys Ala Pro Gly Ser Ala Gly 
            20                  25                  30


His Tyr Glu Leu Pro Trp Val Glu Lys Tyr Arg Pro Val Lys Leu Asn 
        35                  40                  45


Glu Ile Val Gly Asn Glu Asp Thr Val Ser Arg Leu Glu Val Phe Ala 
    50                  55                  60


Arg Glu Gly Asn Val Pro Asn Ile Ile Ile Ala Gly Pro Pro Gly Thr 
65                  70                  75                  80


Gly Lys Thr Thr Ser Ile Leu Cys Leu Ala Arg Ala Leu Leu Gly Pro 
                85                  90                  95


Ala Leu Lys Asp Ala Met Leu Glu Leu Asn Ala Ser Asn Asp Ser Met 
            100                 105                 110


Thr Asp Gly Ala Gln Gln Ala Leu Arg Arg Thr Met Glu Ile Tyr Ser 
        115                 120                 125


Lys Thr Thr Arg Phe Ala Leu Ala Cys Asn Ala Ser Asp Lys Ile Ile 
    130                 135                 140


Glu Pro Ile Gln Ser Arg Cys Ala Val Leu Arg Tyr Thr Lys Leu Thr 
145                 150                 155                 160


Asp Ala Gln Ile Leu Thr Arg Leu Met Asn Val Ile Glu Lys Glu Arg 
                165                 170                 175


Val Pro Tyr Thr Asp Asp Gly Leu Glu Ala Ile Ile Phe Thr Ala Gln 
            180                 185                 190


Gly Asp Met Arg Gln Ala Leu Asn Asn Leu Gln Ser Thr Phe Ser Gly 
        195                 200                 205


Phe Gly Phe Ile Asn Ser Glu Asn Val Phe Lys Val Cys Asp Glu Pro 
    210                 215                 220


His Pro Leu Leu Val Lys Glu Met Ile Gln His Cys Val Asn Ala Asn 
225                 230                 235                 240


Ile Asp Glu Ala Tyr Lys Ile Leu Ala His Leu Trp His Leu Gly Tyr 
                245                 250                 255


Ser Pro Glu Asp Ile Ile Gly Asn Ile Phe Arg Val Cys Lys Thr Phe 
            260                 265                 270


Gln Met Ala Glu Tyr Leu Lys Leu Glu Phe Ile Lys Glu Ile Gly Tyr 
        275                 280                 285


Thr His Met Lys Ile Ala Glu Gly Val Asn Ser Leu Leu Gln Met Ala 
    290                 295                 300


Gly Leu Leu Ala Arg Leu Cys Gln Lys Thr Met Ala Pro Val Ala Ser 
305                 310                 315                 320


<210>  3980
<211>  1553
<212>  DNA
<213>  Homo sapiens

<400>  3980
ggcgtcaagg ggcggtgcct cgggtggcgg gaagaggagg cgcgagaatg gaggtggagg     60

ccgtctgtgg tggcgcgggc gaggtggagg cccaggactc tgaccctgcc cctgccttca    120

gcaaggcccc cggcagcgcc ggccactacg aactgccgtg ggttgaaaaa tataggccag    180

taaagctgaa tgaaattgtc gggaatgaag acaccgtgag caggctagag gtctttgcaa    240

gggaaggaaa tgtgcccaac atcatcattg cgggccctcc aggaaccggc aagaccacaa    300

gcattctgtg cttggcccgg gccctgctgg gcccagcact caaagatgcc atgttggaac    360

tcaatgcttc aaatgacagg ggcattgacg ttgtgaggaa taaaattaaa atgtttgctc    420

aacaaaaagt cactcttccc aaaggccgac ataagatcat cattctggat gaagcagaca    480

gcatgaccga cggagcccag caagccttga ggagaaccat ggaaatctac tctaaaacca    540

ctcgcttcgc ccttgcttgt aatgcttcgg ataagatcat cgagcccatt cagtcccgct    600

gtgcagtcct ccggtacaca aagctgaccg acgcccagat cctcaccagg ctgatgaatg    660

ttatcgagaa ggagagggta ccctacactg atgacggcct agaagccatc atcttcacgg    720

cccagggaga catgaggcag gcgctgaaca acctgcagtc caccttctca ggatttggct    780

tcattaacag tgagaacgtg ttcaaggtct gtgacgagcc ccacccactg ctggtaaagg    840

agatgatcca gcactgtgtg aatgccaaca ttgacgaagc ctacaagatt cttgctcact    900

tgtggcatct gggctactca ccagaagata tcattggcaa catctttcga gtgtgtaaaa    960

ctttccaaat ggcagaatac ctgaaactgg agtttatcaa ggaaattgga tacactcaca   1020

tgaaaatagc ggaaggagtg aactctcttt tgcagatggc aggcctcctg gcaaggctgt   1080

gtcagaagac aatggccccg gtggccagtt agagcagaga cttcactgac tgacttacag   1140

gtgccctatt ctgaggtaca ggagccgcgg ctttctgatg ggggaaaatg ccgccttagg   1200

ctggagccaa catgactgtc ctttaaactc cagtggctgg ccaggcacgg tagctcacgc   1260

ctgtaatccc aacactttgg gaggccgagg caggtggatc acctgaggtc agaagttcaa   1320

gaccagcctg gccaacatgg ggaaaccctg tctttactaa aaatataaaa attagctggg   1380

tgtggtggcg ggcacctgta atcccagcta ctcgggaggc tgtggcagga gaatcgcttg   1440

aacccaggag gtggaggttg cagtgagcca agatcacacc attgcactcc agcctgggcg   1500

acagagtctc catctgggga aaaaaattaa ataaataaac tcccgtgact tgc          1553


<210>  3981
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  3981

Met Glu Val Glu Ala Val Cys Gly Gly Ala Gly Glu Val Glu Ala Gln 
1               5                   10                  15


Asp Ser Asp Pro Ala Pro Ala Phe Ser Lys Ala Pro Gly Ser Ala Gly 
            20                  25                  30


His Tyr Glu Leu Pro Trp Val Glu Lys Tyr Arg Pro Val Lys Leu Asn 
        35                  40                  45


Glu Ile Val Gly Asn Glu Asp Thr Val Ser Arg Leu Glu Val Phe Ala 
    50                  55                  60


Arg Glu Gly Asn Val Pro Asn Ile Ile Ile Ala Gly Pro Pro Gly Thr 
65                  70                  75                  80


Gly Lys Thr Thr Ser Ile Leu Cys Leu Ala Arg Ala Leu Leu Gly Pro 
                85                  90                  95


Ala Leu Lys Asp Ala Met Leu Glu Leu Asn Ala Ser Asn Asp Arg Gly 
            100                 105                 110


Ile Asp Val Val Arg Asn Lys Ile Lys Met Phe Ala Gln Gln Lys Val 
        115                 120                 125


Thr Leu Pro Lys Gly Arg His Lys Ile Ile Ile Leu Asp Glu Ala Asp 
    130                 135                 140


Ser Met Thr Asp Gly Ala Gln Gln Ala Leu Arg Arg Thr Met Glu Ile 
145                 150                 155                 160


Tyr Ser Lys Thr Thr Arg Phe Ala Leu Ala Cys Asn Ala Ser Asp Lys 
                165                 170                 175


Ile Ile Glu Pro Ile Gln Ser Arg Cys Ala Val Leu Arg Tyr Thr Lys 
            180                 185                 190


Leu Thr Asp Ala Gln Ile Leu Thr Arg Leu Met Asn Val Ile Glu Lys 
        195                 200                 205


Glu Arg Val Pro Tyr Thr Asp Asp Gly Leu Glu Ala Ile Ile Phe Thr 
    210                 215                 220


Ala Gln Gly Asp Met Arg Gln Ala Leu Asn Asn Leu Gln Ser Thr Phe 
225                 230                 235                 240


Ser Gly Phe Gly Phe Ile Asn Ser Glu Asn Val Phe Lys Val Cys Asp 
                245                 250                 255


Glu Pro His Pro Leu Leu Val Lys Glu Met Ile Gln His Cys Val Asn 
            260                 265                 270


Ala Asn Ile Asp Glu Ala Tyr Lys Ile Leu Ala His Leu Trp His Leu 
        275                 280                 285


Gly Tyr Ser Pro Glu Asp Ile Ile Gly Asn Ile Phe Arg Val Cys Lys 
    290                 295                 300


Thr Phe Gln Met Ala Glu Tyr Leu Lys Leu Glu Phe Ile Lys Glu Ile 
305                 310                 315                 320


Gly Tyr Thr His Met Lys Ile Ala Glu Gly Val Asn Ser Leu Leu Gln 
                325                 330                 335


Met Ala Gly Leu Leu Ala Arg Leu Cys Gln Lys Thr Met Ala Pro Val 
            340                 345                 350


Ala Ser 



<210>  3982
<211>  1406
<212>  DNA
<213>  Homo sapiens

<400>  3982
caggaaacca tggcttccac cgggaaaagg caagggcagg tgtgggtgac ctctggagcc     60

atcaggaggc tttcattggg aagatgtagg ggtcgacatt gtaccagagg cagagcctca    120

tgccactgcg gagaatgctg cagggaggac ggagtcccca gcaccatgca cctgcctgct    180

ggagtagcct gaccccttgt ttagggtgtc aggctgaggc tgggggacct tttgtaggga    240

aggccagttc ctactccggg gtggaggtgg gaattggccc aaaagacctc ccagttctaa    300

agtgaattcc aagtggttct gggcaactga ccccccaagt gatctaagac agatgacttg    360

tgactttaaa gctgtcccca agtgagcatc cttcacaggc ccttggttgc tctcttgttc    420

atctgtctta tgtttgggaa atttatcttc ctggtgccgg aagcacttct ctttgatggt    480

gagaggagca ttccccaaac tcatcctggt tgctggagaa tttgatgaaa acaacaggtt    540

gagaagtttt acccatagat tgcctggaag tcggtctgtt ggggcctccc cgctcacatt    600

gtcccttcta gcccctgacc gcctttcctt tccctttggc caggtctgtg acgagcccca    660

cccactgctg gtaaaggaga tgatccagca ctgtgtgaat gccaacattg acgaagccta    720

caagattctt gctcacttgt ggcatctggg ctactcacca gaagatatca ttggcaacat    780

ctttcgagtg tgtaaaactt tccaaatggc agaatacctg aaactggagt ttatcaaggt    840

cggtgagaat gtagaaatgc ctctgtcctc aagaatgtgg cccatagtgg ccgggtgctg    900

tgggccacac ctgtaatccc agcactttgg gaggccgagg tgggcagatc acctgaggtc    960

aggagttcga gaccagcctg gccaacgtag tgaaagcctc tgtctactaa aaatacaaaa   1020

attagctggg catggctggg cgtggtggct catgcctgta atcccagcac tttgggaggc   1080

cgaggtgggc ggatcacctg aggtcaggag tttgagacca gcctggccaa catggcaaag   1140

ccccatctct actaaaaata caaaacttag ctgggtgtgg tggcaagcgc ctataatccc   1200

agctacttgg gaggctgagg gaggaggatc gcttgaacct gggaggtgga ggttgcagtg   1260

agccaagatc gcaccactgc actccagcct gggcagcaga gcgagactgt ctcaaaacaa   1320

aaaaaaaaga ctgtgggccc tggcttcgct ttctctgctc acaggcctgg catctagaag   1380

gtgctcagtg tttcccaact gcagtg                                        1406


<210>  3983
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  3983

Met Val Arg Gly Ala Phe Pro Lys Leu Ile Leu Val Ala Gly Glu Phe 
1               5                   10                  15


Asp Glu Asn Asn Arg Leu Arg Ser Phe Thr His Arg Leu Pro Gly Ser 
            20                  25                  30


Arg Ser Val Gly Ala Ser Pro Leu Thr Leu Ser Leu Leu Ala Pro Asp 
        35                  40                  45


Arg Leu Ser Phe Pro Phe Gly Gln Val Cys Asp Glu Pro His Pro Leu 
    50                  55                  60


Leu Val Lys Glu Met Ile Gln His Cys Val Asn Ala Asn Ile Asp Glu 
65                  70                  75                  80


Ala Tyr Lys Ile Leu Ala His Leu Trp His Leu Gly Tyr Ser Pro Glu 
                85                  90                  95


Asp Ile Ile Gly Asn Ile Phe Arg Val Cys Lys Thr Phe Gln Met Ala 
            100                 105                 110


Glu Tyr Leu Lys Leu Glu Phe Ile Lys Val Gly Glu Asn Val Glu Met 
        115                 120                 125


Pro Leu Ser Ser Arg Met Trp Pro Ile Val Ala Gly Cys Cys Gly Pro 
    130                 135                 140


His Leu 
145


<210>  3984
<211>  424
<212>  DNA
<213>  Homo sapiens

<400>  3984
attcttatgg gctgtttttc tacccaatct ttcctcccat agcccaaatt gtcataatat     60

tcaataatga tgatcccaga actttgggag gctaaggtgg gaggatccct caaactcctg    120

acttcaagtg atccgcttgc ctcagcctcc caaagtgctg ggattacagg tgtgagccac    180

cgcgtctggc caagcagttg gttttaacga tagtattaac gtatacagat tcacaactta    240

acacagtgtt tttctttcca tgtaatttgg aaaaaatgtt tgaattggcc atctctcccc    300

tattccccct ttaaactgat ggagcggtct tgtctgtttt ttcaatcatt attcacaggt    360

cttttatttt tccggaggag aaaatacaca ctcctcttga aatatacact tttcttgaaa    420

tgtc                                                                 424


<210>  3985
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  3985

Met Met Ile Pro Glu Leu Trp Glu Ala Lys Val Gly Gly Ser Leu Lys 
1               5                   10                  15


Leu Leu Thr Ser Ser Asp Pro Leu Ala Ser Ala Ser Gln Ser Ala Gly 
            20                  25                  30


Ile Thr Gly Val Ser His Arg Val Trp Pro Ser Ser Trp Phe 
        35                  40                  45


<210>  3986
<211>  5499
<212>  DNA
<213>  Homo sapiens

<400>  3986
gctggctccg ctggctccgc tggctccgcg ggcgctcagc tcggctcggc cgcggggcgc     60

gcaggcggct gctgggcggc ctcggtgcgc gcctcccgcc ttcccagaga cgtggcgcga    120

ggcccgggcc ctgagcacct atcgcgggga tccccggcgc caggaggggg tgcagccggt    180

gggcagcgcc gcgcagggag gggccgcagc atcctcgccc cccagcgcgc ccgggcccga    240

gaggaggagg ccggggctct ccgggcctcc cgccgcttag cctgatgctg gaaggacgaa    300

ggtgagtgaa gatggcagag aggacgtgac cagcactcac ccttgtccac ctgcccagtg    360

gcaccgccat gcagaagccc agcggcctga agccccccgg ccgtgggggg aagcactcca    420

gccccatggg ccggacatct actgggtcag cttcatcctc ggcggcggtg gccgctagct    480

ccaaggaagg ctccccactg cacaaacagt catctggacc ctcctcctcc ccggccgcag    540

ctgctgcccc cgagaagccg ggccccaagg cggcggaagt gggggatgac ttcctggggg    600

actttgtggt gggcgagcgg gtgtgggtga acggcgtgaa gccaggcgtg gtgcagtatc    660

tgggagagac gcagttcgca ccgggccagt gggctggcgt ggtgctggac gacccggtgg    720

gcaagaatga tggcgcggtg ggcggcgtgc gctacttcga gtgcccggcc ctccagggta    780

tcttcacgcg gccctccaag ctgacccggc agcccacggc cgagggctcg gggagtgatg    840

cccactccgt ggagtcgctg actgcccaga acctgtcatt gcattcgggc acggccacgc    900

ccccgctgac cagccgcgtc atccccctgc gggagagcgt cctcaacagc tccgtgaaga    960

ctggcaacga gtcgggatcc aacctctcag acagcggctc tgtgaagcgg ggcgaaaagg   1020

acctgcgcct gggggaccgc gtgctggttg gcgggacgaa gactggcgtg gtgcggtacg   1080

tgggggagac agactttgcc aagggcgagt ggtgtggcgt ggagctggac gagccccttg   1140

ggaagaatga tggggcggtg gcgggcacca ggtacttcca gtgcccaccc aagtttggtc   1200

tcttcgcgcc catccacaaa gtgatccgta tcggcttccc atctaccagc ccagccaagg   1260

ccaagaagac caagcgtatg gccatgggtg tgtcagcact gacccacagt cccagcagtt   1320

cctccatcag ctccgtcagc tctgtggcct cctccgtggg gggtcggccc agccgcagtg   1380

gcctgctcac ggagacctct tcacgctacg cccgcaagat ctcgggcacc acggccttgc   1440

aggaggcact gaaggagaag cagcagcaca ttgagcagct gctggctgaa cgagacctgg   1500

aacgggctga ggtggccaag gccacaagcc acatctgcga ggtggagaag gagattgccc   1560

tgctcaaggc acagcatgag cagtatgttg cagaagccga ggagaagctg cagcgagccc   1620

ggctgctcgt ggagagcgtg cggaaagaga aggtggacct gtccaaccag ctggaggagg   1680

agaggaggaa ggtggaggat ctgcagttcc gcgtggagga ggagtccatc accaagggag   1740

acctggagct gaccacagtg gccgagaagt cgcgcgtgct gcagctggag gaggagctca   1800

ccctgcgccg aggtgaaatc gaggagctcc agcagtgcct gttgcactcg ggtcccccac   1860

ctccggacca cccagacgcc gccgagatcc tgcggctacg ggagcggctg ctctcggcca   1920

gcaaggaaca ccagagggag agtggggtgc tgcgggataa atacgagaag gccctgaagg   1980

cctaccaggc ggaggtggac aagctccgcg cggccaacga gaagtacgca caggaggtgg   2040

cgggcctgaa ggacaaggtt cagcaggcca ccagcgagaa catggggcta atggacaact   2100

ggaaatccaa gctggactcg ctggcctcgg accaccagaa gtccctggag gacctcaaag   2160

ccaccctgaa ctcgggccca ggcgcccagc agaaggagat cggcgagctg aaggcagtga   2220

tggagggcat caagatggag caccagctgg agctgggtaa cttgcaggcc aagcatgacc   2280

tggagaccgc catgcacgtg aaggagaagg aggccctgcg agagaagctg caggaggccc   2340

aggaggagct ggctgggctg cagcggcact ggcgggccca gctggaggtg caagccagcc   2400

agcaccggct ggagctgcag gaggcccagg accagcgccg ggatgccgag ctgcgtgtgc   2460

acgagctgga aaaactggac gtggagtacc ggggccaggc gcaggctatc gagttcctca   2520

aggagcagat ctcgctggcc gagaagaaga tgttggacta cgagcggctg cagcgggcag   2580

aagcccaggg caaacaggag gtcgagagtt tgcgggagaa gctcctggtg gctgagaaca   2640

gactccaggc ggtcgaggcc ctgtgctcct cccagcacac ccacatgatt gagtcgaatg   2700

acatttcaga ggagacgatc aggacgaagg aaactgtgga gggcctgcag gacaagctga   2760

acaagaggga caaagaggtg acagccttga cctcccagac cgagatgctc agggcccaag   2820

taagtgcgct ggagagcaag tgtaagtcag gcgagaagaa ggtggacgcc ctcctgaagg   2880

agaagcggcg cctggaggca gagctggaga ccgtgtcccg gaagacccat gacgcctcgg   2940

gccagctagt cctcatcagc caggagctgc tgcggaagga gcggagcctg aacgaactgc   3000

gggtgttgct gctggaggcc aatcgtcact ccccagggcc ggagagggac ctgagccgtg   3060

aggtacacaa ggctgagtgg cggatcaagg agcagaaact caaggatgac atccggggcc   3120

tgcgtgaaaa gctgaccggg ctggacaaag agaaatccct gtcggatcag aggcgctact   3180

ccctcatcga ccggtcctcg gcgcccgagc ttctgcggct gcagcaccag ctgatgagca   3240

cggaggacgc cctgcgggat gcgctggacc aggctcagca ggtggagaag ctgatggagg   3300

ccatgaggag ctgccctgac aaggcccaga ccatcggcaa ttccggttct gcaaacggca   3360

tccaccagca ggacaaagct cagaaacaag aggacaagca ctgatcctga ggggatactg   3420

tggagcagcc cagtccacac cagagcccca cgcggctgcc cggcagtacc tcctccaggc   3480

aggagccggg actgtcactt tggagacaaa acagtgtttg taacaataac gtactcaccg   3540

ccgcggacaa tcccccaccc cgatccctcg ccagaccagg acgcttcctc aagcccagcc   3600

ttctacagag agtgtgaacg gtacagcccc ggcctgaccc ggggaccttc agcctggaca   3660

cccggcagct tctggagttt gtcagtggag gcagagggga tccggccagg cccctctgtc   3720

cagaaggagc tgccctgagg accatcttag cggccctgtc ctctttttcc gcccattctc   3780

cctcgggtct ccccagaggg gccggcgggg gctggggagg gggtaagttt atccatgcag   3840

acaccaaggg ggagcatcca gtctttaaga gccaagtggg ggcccctttt ccgaagccac   3900

ttccaggcca aggcagtcgc cagggcttct tgtccccacc ttctgaacct tcttcaaaca   3960

gtagtacaag ctcccctcag ccagcctgcc tgcccagcga ggcccccagg ttcaaggtgt   4020

tggcgggggc ggagggcagg ggaacgggat ccttctcccg ctgcccacca acaccaacac   4080

acacacacct ctaagctgct ggccgaagat gtcaccaagg ccaaagacac agtattatga   4140

aggtttggaa acccctctcc tcacctccca ccgtgacctt gggcaaaccc tggctcggag   4200

cccagggcag aggcagctca gagtggaggc tctaggcagg tttgacaaag gtcagtaata   4260

cggtttcccc tggggttgac cagatgttcc aaaatatctg catccacctg gagatgcagc   4320

taagtgggtc cttatgtaca caccacgttc acacacacac agagggacca cgtgtgcacg   4380

catgaccgtg tgggtggcgg cgtttgctgt gaaccacgct caggccacac agagacacat   4440

acttggtttc tgggactgag acccaggcct ggcaggaccg tgcctacaga tactgcaaac   4500

gttcctacag cctagaggtg cgtatacaca cccaagtaca cgcagccagg cattcagggg   4560

tgtgtttgcc acatggagca tcccttcctg gtcttgccag gcacctgcac agagcgtctc   4620

cagccccatc tcctaacggg ggctgggggt aagagaaatc taactgcgct cccccaaccc   4680

ctcgccctgc catcttcccc tcaagcctgc taagttatcc caggcctgtg cgtggtggaa   4740

aaagccagcc ttggccctgc agcctccacc tcgccgctgg gggaccaaca ggttgcttac   4800

agctttgcac cccggcatca gcacaggggt ccctgcccca ccctccggca gctcagggag   4860

tgttttcctg tgaggcctcc cccatcagtg gaccagaggg agaagcccga tgccccatcc   4920

cggctttccc gtaacgcaca ggacacgtgt gcaattcata ggaacggccc agatcgccct   4980

catgagtgcc acctggtaca ggtaggtggc gctcacgttc ctgcccaaat gcagcccatc   5040

ggggagtcac agtcagtccc cccggccccc ctcccagtcc ctgttggctt tcggtagctc   5100

tcgcatgcag ttctattaac agccgtctag aagcgatgct ttagtggcct aacccagggt   5160

caaatacagc tctttctagc aaaatcaggc agctctgccc catcggtagg ggcaccgatt   5220

agtctactaa cagccagagg tccatctagc agggtgccgg gaggagctga gcccccggag   5280

gtgggctcct ggtgacgggt gtccaagaag cggtttcctt gggagcttct gcctccgtgg   5340

gcctctcagc ccgccccgtg tggccgcccg ggtgtggctc agccatgtcc cctccccagg   5400

tccttcattc acccctcccc tccccacagt ggaattgttg aagtgtggcg agtctgtgct   5460

cgggacaata aagcttgtga caggtccagg accccggca                          5499


<210>  3987
<211>  1011
<212>  PRT
<213>  Homo sapiens

<400>  3987

Met Gln Lys Pro Ser Gly Leu Lys Pro Pro Gly Arg Gly Gly Lys His 
1               5                   10                  15


Ser Ser Pro Met Gly Arg Thr Ser Thr Gly Ser Ala Ser Ser Ser Ala 
            20                  25                  30


Ala Val Ala Ala Ser Ser Lys Glu Gly Ser Pro Leu His Lys Gln Ser 
        35                  40                  45


Ser Gly Pro Ser Ser Ser Pro Ala Ala Ala Ala Ala Pro Glu Lys Pro 
    50                  55                  60


Gly Pro Lys Ala Ala Glu Val Gly Asp Asp Phe Leu Gly Asp Phe Val 
65                  70                  75                  80


Val Gly Glu Arg Val Trp Val Asn Gly Val Lys Pro Gly Val Val Gln 
                85                  90                  95


Tyr Leu Gly Glu Thr Gln Phe Ala Pro Gly Gln Trp Ala Gly Val Val 
            100                 105                 110


Leu Asp Asp Pro Val Gly Lys Asn Asp Gly Ala Val Gly Gly Val Arg 
        115                 120                 125


Tyr Phe Glu Cys Pro Ala Leu Gln Gly Ile Phe Thr Arg Pro Ser Lys 
    130                 135                 140


Leu Thr Arg Gln Pro Thr Ala Glu Gly Ser Gly Ser Asp Ala His Ser 
145                 150                 155                 160


Val Glu Ser Leu Thr Ala Gln Asn Leu Ser Leu His Ser Gly Thr Ala 
                165                 170                 175


Thr Pro Pro Leu Thr Ser Arg Val Ile Pro Leu Arg Glu Ser Val Leu 
            180                 185                 190


Asn Ser Ser Val Lys Thr Gly Asn Glu Ser Gly Ser Asn Leu Ser Asp 
        195                 200                 205


Ser Gly Ser Val Lys Arg Gly Glu Lys Asp Leu Arg Leu Gly Asp Arg 
    210                 215                 220


Val Leu Val Gly Gly Thr Lys Thr Gly Val Val Arg Tyr Val Gly Glu 
225                 230                 235                 240


Thr Asp Phe Ala Lys Gly Glu Trp Cys Gly Val Glu Leu Asp Glu Pro 
                245                 250                 255


Leu Gly Lys Asn Asp Gly Ala Val Ala Gly Thr Arg Tyr Phe Gln Cys 
            260                 265                 270


Pro Pro Lys Phe Gly Leu Phe Ala Pro Ile His Lys Val Ile Arg Ile 
        275                 280                 285


Gly Phe Pro Ser Thr Ser Pro Ala Lys Ala Lys Lys Thr Lys Arg Met 
    290                 295                 300


Ala Met Gly Val Ser Ala Leu Thr His Ser Pro Ser Ser Ser Ser Ile 
305                 310                 315                 320


Ser Ser Val Ser Ser Val Ala Ser Ser Val Gly Gly Arg Pro Ser Arg 
                325                 330                 335


Ser Gly Leu Leu Thr Glu Thr Ser Ser Arg Tyr Ala Arg Lys Ile Ser 
            340                 345                 350


Gly Thr Thr Ala Leu Gln Glu Ala Leu Lys Glu Lys Gln Gln His Ile 
        355                 360                 365


Glu Gln Leu Leu Ala Glu Arg Asp Leu Glu Arg Ala Glu Val Ala Lys 
    370                 375                 380


Ala Thr Ser His Ile Cys Glu Val Glu Lys Glu Ile Ala Leu Leu Lys 
385                 390                 395                 400


Ala Gln His Glu Gln Tyr Val Ala Glu Ala Glu Glu Lys Leu Gln Arg 
                405                 410                 415


Ala Arg Leu Leu Val Glu Ser Val Arg Lys Glu Lys Val Asp Leu Ser 
            420                 425                 430


Asn Gln Leu Glu Glu Glu Arg Arg Lys Val Glu Asp Leu Gln Phe Arg 
        435                 440                 445


Val Glu Glu Glu Ser Ile Thr Lys Gly Asp Leu Glu Leu Thr Thr Val 
    450                 455                 460


Ala Glu Lys Ser Arg Val Leu Gln Leu Glu Glu Glu Leu Thr Leu Arg 
465                 470                 475                 480


Arg Gly Glu Ile Glu Glu Leu Gln Gln Cys Leu Leu His Ser Gly Pro 
                485                 490                 495


Pro Pro Pro Asp His Pro Asp Ala Ala Glu Ile Leu Arg Leu Arg Glu 
            500                 505                 510


Arg Leu Leu Ser Ala Ser Lys Glu His Gln Arg Glu Ser Gly Val Leu 
        515                 520                 525


Arg Asp Lys Tyr Glu Lys Ala Leu Lys Ala Tyr Gln Ala Glu Val Asp 
    530                 535                 540


Lys Leu Arg Ala Ala Asn Glu Lys Tyr Ala Gln Glu Val Ala Gly Leu 
545                 550                 555                 560


Lys Asp Lys Val Gln Gln Ala Thr Ser Glu Asn Met Gly Leu Met Asp 
                565                 570                 575


Asn Trp Lys Ser Lys Leu Asp Ser Leu Ala Ser Asp His Gln Lys Ser 
            580                 585                 590


Leu Glu Asp Leu Lys Ala Thr Leu Asn Ser Gly Pro Gly Ala Gln Gln 
        595                 600                 605


Lys Glu Ile Gly Glu Leu Lys Ala Val Met Glu Gly Ile Lys Met Glu 
    610                 615                 620


His Gln Leu Glu Leu Gly Asn Leu Gln Ala Lys His Asp Leu Glu Thr 
625                 630                 635                 640


Ala Met His Val Lys Glu Lys Glu Ala Leu Arg Glu Lys Leu Gln Glu 
                645                 650                 655


Ala Gln Glu Glu Leu Ala Gly Leu Gln Arg His Trp Arg Ala Gln Leu 
            660                 665                 670


Glu Val Gln Ala Ser Gln His Arg Leu Glu Leu Gln Glu Ala Gln Asp 
        675                 680                 685


Gln Arg Arg Asp Ala Glu Leu Arg Val His Glu Leu Glu Lys Leu Asp 
    690                 695                 700


Val Glu Tyr Arg Gly Gln Ala Gln Ala Ile Glu Phe Leu Lys Glu Gln 
705                 710                 715                 720


Ile Ser Leu Ala Glu Lys Lys Met Leu Asp Tyr Glu Arg Leu Gln Arg 
                725                 730                 735


Ala Glu Ala Gln Gly Lys Gln Glu Val Glu Ser Leu Arg Glu Lys Leu 
            740                 745                 750


Leu Val Ala Glu Asn Arg Leu Gln Ala Val Glu Ala Leu Cys Ser Ser 
        755                 760                 765


Gln His Thr His Met Ile Glu Ser Asn Asp Ile Ser Glu Glu Thr Ile 
    770                 775                 780


Arg Thr Lys Glu Thr Val Glu Gly Leu Gln Asp Lys Leu Asn Lys Arg 
785                 790                 795                 800


Asp Lys Glu Val Thr Ala Leu Thr Ser Gln Thr Glu Met Leu Arg Ala 
                805                 810                 815


Gln Val Ser Ala Leu Glu Ser Lys Cys Lys Ser Gly Glu Lys Lys Val 
            820                 825                 830


Asp Ala Leu Leu Lys Glu Lys Arg Arg Leu Glu Ala Glu Leu Glu Thr 
        835                 840                 845


Val Ser Arg Lys Thr His Asp Ala Ser Gly Gln Leu Val Leu Ile Ser 
    850                 855                 860


Gln Glu Leu Leu Arg Lys Glu Arg Ser Leu Asn Glu Leu Arg Val Leu 
865                 870                 875                 880


Leu Leu Glu Ala Asn Arg His Ser Pro Gly Pro Glu Arg Asp Leu Ser 
                885                 890                 895


Arg Glu Val His Lys Ala Glu Trp Arg Ile Lys Glu Gln Lys Leu Lys 
            900                 905                 910


Asp Asp Ile Arg Gly Leu Arg Glu Lys Leu Thr Gly Leu Asp Lys Glu 
        915                 920                 925


Lys Ser Leu Ser Asp Gln Arg Arg Tyr Ser Leu Ile Asp Arg Ser Ser 
    930                 935                 940


Ala Pro Glu Leu Leu Arg Leu Gln His Gln Leu Met Ser Thr Glu Asp 
945                 950                 955                 960


Ala Leu Arg Asp Ala Leu Asp Gln Ala Gln Gln Val Glu Lys Leu Met 
                965                 970                 975


Glu Ala Met Arg Ser Cys Pro Asp Lys Ala Gln Thr Ile Gly Asn Ser 
            980                 985                 990


Gly Ser Ala Asn Gly Ile His Gln Gln Asp Lys Ala Gln Lys Gln Glu 
        995                 1000                1005


Asp Lys His 
    1010


<210>  3988
<211>  5604
<212>  DNA
<213>  Homo sapiens

<400>  3988
gctggctccg ctggctccgc tggctccgcg ggcgctcagc tcggctcggc cgcggggcgc     60

gcaggcggct gctgggcggc ctcggtgcgc gcctcccgcc ttcccagaga cgtggcgcga    120

ggcccgggcc ctgagcacct atcgcgggga tccccggcgc caggaggggg tgcagccggt    180

gggcagcgcc gcgcagggag gggccgcagc atcctcgccc cccagcgcgc ccgggcccga    240

gaggaggagg ccggggctct ccgggcctcc cgccgcttag cctgatgctg gaaggacgaa    300

ggtgagtgaa gatggcagag aggacgtgac cagcactcac ccttgtccac ctgcccagtg    360

gcaccgccat gcagaagccc agcggcctga agccccccgg ccgtgggggg aagcactcca    420

gccccatggg ccggacatct actgggtcag cttcatcctc ggcggcggtg gccgctagct    480

ccaaggaagg ctccccactg cacaaacagt catctggacc ctcctcctcc ccggccgcag    540

ctgctgcccc cgagaagccg ggccccaagg cggcggaagt gggggatgac ttcctggggg    600

actttgtggt gggcgagcgg gtgtgggtga acggcgtgaa gccaggcgtg gtgcagtatc    660

tgggagagac gcagttcgca ccgggccagt gggctggcgt ggtgctggac gacccggtgg    720

gcaagaatga tggcgcggtg ggcggcgtgc gctacttcga gtgcccggcc ctccagggta    780

tcttcacgcg gccctccaag ctgacccggc agcccacggc cgagggctcg gggagtgatg    840

cccactccgt ggagtcgctg actgcccaga acctgtcatt gcattcgggc acggccacgc    900

ccccgctgac cagccgcgtc atccccctgc gggagagcgt cctcaacagc tccgtgaaga    960

ctggcaacga gtcgggatcc aacctctcag acagcggctc tgtgaagcgg ggcgaaaagg   1020

acctgcgcct gggggaccgc gtgctggttg gcgggacgaa gactggcgtg gtgcggtacg   1080

tgggggagac agactttgcc aagggcgagt ggtgtggcgt ggagctggac gagccccttg   1140

ggaagaatga tggggcggtg gcgggcacca ggtacttcca gtgcccaccc aagtttggtc   1200

tcttcgcgcc catccacaaa gtgatccgta tcggcttccc atctaccagc ccagccaagg   1260

ccaagaagac caagcgtatg gccatgggtg tgtcagcact gacccacagt cccagcagtt   1320

cctccatcag ctccgtcagc tctgtggcct cctccgtggg gggtcggccc agccgcagtg   1380

gcctgctcac ggagacctct tcacgctacg cccgcaagat ctcgggcacc acggccttgc   1440

aggaggcact gaaggagaag cagcagcaca ttgagcagct gctggctgaa cgagacctgg   1500

aacgggctga ggtggccaag gccacaagcc acatctgcga ggtggagaag gagattgccc   1560

tgctcaaggc acagcatgag cagtatgttg cagaagccga ggagaagctg cagcgagccc   1620

ggctgctcgt ggagagcgtg cggaaagaga aggtggacct gtccaaccag ctggaggagg   1680

agaggaggaa ggtggaggat ctgcagttcc gcgtggagga ggagtccatc accaagggag   1740

acctggagac ccagacgcag ctggagcacg cgcgcattgg ggagctggaa cagagcctgc   1800

tactggagaa ggcgcaggcc gagcggctgc tccgagaatt agcggacaac aggctgacca   1860

cagtggccga gaagtcgcgc gtgctgcagc tggaggagga gctcaccctg cgccgaggtg   1920

aaatcgagga gctccagcag tgcctgttgc actcgggtcc cccacctccg gaccacccag   1980

acgccgccga gatcctgcgg ctacgggagc ggctgctctc ggccagcaag gaacaccaga   2040

gggagagtgg ggtgctgcgg gataaatacg agaaggccct gaaggcctac caggcggagg   2100

tggacaagct ccgcgcggcc aacgagaagt acgcacagga ggtggcgggc ctgaaggaca   2160

aggttcagca ggccaccagc gagaacatgg ggctaatgga caactggaaa tccaagctgg   2220

actcgctggc ctcggaccac cagaagtccc tggaggacct caaagccacc ctgaactcgg   2280

gcccaggcgc ccagcagaag gagatcggcg agctgaaggc agtgatggag ggcatcaaga   2340

tggagcacca gctggagctg ggtaacttgc aggccaagca tgacctggag accgccatgc   2400

acgtgaagga gaaggaggcc ctgcgagaga agctgcagga ggcccaggag gagctggctg   2460

ggctgcagcg gcactggcgg gcccagctgg aggtgcaagc cagccagcac cggctggagc   2520

tgcaggaggc ccaggaccag cgccgggatg ccgagctgcg tgtgcacgag ctggaaaaac   2580

tggacgtgga gtaccggggc caggcgcagg ctatcgagtt cctcaaggag cagatctcgc   2640

tggccgagaa gaagatgttg gactacgagc ggctgcagcg ggcagaagcc cagggcaaac   2700

aggaggtcga gagtttgcgg gagaagctcc tggtggctga gaacagactc caggcggtcg   2760

aggccctgtg ctcctcccag cacacccaca tgattgagtc gaatgacatt tcagaggaga   2820

cgatcaggac gaaggaaact gtggagggcc tgcaggacaa gctgaacaag agggacaaag   2880

aggtgacagc cttgacctcc cagaccgaga tgctcagggc ccaagtaagt gcgctggaga   2940

gcaagtgtaa gtcaggcgag aagaaggtgg acgccctcct gaaggagaag cggcgcctgg   3000

aggcagagct ggagaccgtg tcccggaaga cccatgacgc ctcgggccag ctagtcctca   3060

tcagccagga gctgctgcgg aaggagcgga gcctgaacga actgcgggtg ttgctgctgg   3120

aggccaatcg tcactcccca gggccggaga gggacctgag ccgtgaggta cacaaggctg   3180

agtggcggat caaggagcag aaactcaagg atgacatccg gggcctgcgt gaaaagctga   3240

ccgggctgga caaagagaaa tccctgtcgg atcagaggcg ctactccctc atcgaccggt   3300

cctcggcgcc cgagcttctg cggctgcagc accagctgat gagcacggag gacgccctgc   3360

gggatgcgct ggaccaggct cagcaggtgg agaagctgat ggaggccatg aggagctgcc   3420

ctgacaaggc ccagaccatc ggcaattccg gttctgcaaa cggcatccac cagcaggaca   3480

aagctcagaa acaagaggac aagcactgat cctgagggga tactgtggag cagcccagtc   3540

cacaccagag ccccacgcgg ctgcccggca gtacctcctc caggcaggag ccgggactgt   3600

cactttggag acaaaacagt gtttgtaaca ataacgtact caccgccgcg gacaatcccc   3660

caccccgatc cctcgccaga ccaggacgct tcctcaagcc cagccttcta cagagagtgt   3720

gaacggtaca gccccggcct gacccgggga ccttcagcct ggacacccgg cagcttctgg   3780

agtttgtcag tggaggcaga ggggatccgg ccaggcccct ctgtccagaa ggagctgccc   3840

tgaggaccat cttagcggcc ctgtcctctt tttccgccca ttctccctcg ggtctcccca   3900

gaggggccgg cgggggctgg ggagggggta agtttatcca tgcagacacc aagggggagc   3960

atccagtctt taagagccaa gtgggggccc cttttccgaa gccacttcca ggccaaggca   4020

gtcgccaggg cttcttgtcc ccaccttctg aaccttcttc aaacagtagt acaagctccc   4080

ctcagccagc ctgcctgccc agcgaggccc ccaggttcaa ggtgttggcg ggggcggagg   4140

gcaggggaac gggatccttc tcccgctgcc caccaacacc aacacacaca cacctctaag   4200

ctgctggccg aagatgtcac caaggccaaa gacacagtat tatgaaggtt tggaaacccc   4260

tctcctcacc tcccaccgtg accttgggca aaccctggct cggagcccag ggcagaggca   4320

gctcagagtg gaggctctag gcaggtttga caaaggtcag taatacggtt tcccctgggg   4380

ttgaccagat gttccaaaat atctgcatcc acctggagat gcagctaagt gggtccttat   4440

gtacacacca cgttcacaca cacacagagg gaccacgtgt gcacgcatga ccgtgtgggt   4500

ggcggcgttt gctgtgaacc acgctcaggc cacacagaga cacatacttg gtttctggga   4560

ctgagaccca ggcctggcag gaccgtgcct acagatactg caaacgttcc tacagcctag   4620

aggtgcgtat acacacccaa gtacacgcag ccaggcattc aggggtgtgt ttgccacatg   4680

gagcatccct tcctggtctt gccaggcacc tgcacagagc gtctccagcc ccatctccta   4740

acgggggctg ggggtaagag aaatctaact gcgctccccc aacccctcgc cctgccatct   4800

tcccctcaag cctgctaagt tatcccaggc ctgtgcgtgg tggaaaaagc cagccttggc   4860

cctgcagcct ccacctcgcc gctgggggac caacaggttg cttacagctt tgcaccccgg   4920

catcagcaca ggggtccctg ccccaccctc cggcagctca gggagtgttt tcctgtgagg   4980

cctcccccat cagtggacca gagggagaag cccgatgccc catcccggct ttcccgtaac   5040

gcacaggaca cgtgtgcaat tcataggaac ggcccagatc gccctcatga gtgccacctg   5100

gtacaggtag gtggcgctca cgttcctgcc caaatgcagc ccatcgggga gtcacagtca   5160

gtccccccgg cccccctccc agtccctgtt ggctttcggt agctctcgca tgcagttcta   5220

ttaacagccg tctagaagcg atgctttagt ggcctaaccc agggtcaaat acagctcttt   5280

ctagcaaaat caggcagctc tgccccatcg gtaggggcac cgattagtct actaacagcc   5340

agaggtccat ctagcagggt gccgggagga gctgagcccc cggaggtggg ctcctggtga   5400

cgggtgtcca agaagcggtt tccttgggag cttctgcctc cgtgggcctc tcagcccgcc   5460

ccgtgtggcc gcccgggtgt ggctcagcca tgtcccctcc ccaggtcctt cattcacccc   5520

tcccctcccc acagtggaat tgttgaagtg tggcgagtct gtgctcggga caataaagct   5580

tgtgacaggt ccaggacccc ggca                                          5604


<210>  3989
<211>  1046
<212>  PRT
<213>  Homo sapiens

<400>  3989

Met Gln Lys Pro Ser Gly Leu Lys Pro Pro Gly Arg Gly Gly Lys His 
1               5                   10                  15


Ser Ser Pro Met Gly Arg Thr Ser Thr Gly Ser Ala Ser Ser Ser Ala 
            20                  25                  30


Ala Val Ala Ala Ser Ser Lys Glu Gly Ser Pro Leu His Lys Gln Ser 
        35                  40                  45


Ser Gly Pro Ser Ser Ser Pro Ala Ala Ala Ala Ala Pro Glu Lys Pro 
    50                  55                  60


Gly Pro Lys Ala Ala Glu Val Gly Asp Asp Phe Leu Gly Asp Phe Val 
65                  70                  75                  80


Val Gly Glu Arg Val Trp Val Asn Gly Val Lys Pro Gly Val Val Gln 
                85                  90                  95


Tyr Leu Gly Glu Thr Gln Phe Ala Pro Gly Gln Trp Ala Gly Val Val 
            100                 105                 110


Leu Asp Asp Pro Val Gly Lys Asn Asp Gly Ala Val Gly Gly Val Arg 
        115                 120                 125


Tyr Phe Glu Cys Pro Ala Leu Gln Gly Ile Phe Thr Arg Pro Ser Lys 
    130                 135                 140


Leu Thr Arg Gln Pro Thr Ala Glu Gly Ser Gly Ser Asp Ala His Ser 
145                 150                 155                 160


Val Glu Ser Leu Thr Ala Gln Asn Leu Ser Leu His Ser Gly Thr Ala 
                165                 170                 175


Thr Pro Pro Leu Thr Ser Arg Val Ile Pro Leu Arg Glu Ser Val Leu 
            180                 185                 190


Asn Ser Ser Val Lys Thr Gly Asn Glu Ser Gly Ser Asn Leu Ser Asp 
        195                 200                 205


Ser Gly Ser Val Lys Arg Gly Glu Lys Asp Leu Arg Leu Gly Asp Arg 
    210                 215                 220


Val Leu Val Gly Gly Thr Lys Thr Gly Val Val Arg Tyr Val Gly Glu 
225                 230                 235                 240


Thr Asp Phe Ala Lys Gly Glu Trp Cys Gly Val Glu Leu Asp Glu Pro 
                245                 250                 255


Leu Gly Lys Asn Asp Gly Ala Val Ala Gly Thr Arg Tyr Phe Gln Cys 
            260                 265                 270


Pro Pro Lys Phe Gly Leu Phe Ala Pro Ile His Lys Val Ile Arg Ile 
        275                 280                 285


Gly Phe Pro Ser Thr Ser Pro Ala Lys Ala Lys Lys Thr Lys Arg Met 
    290                 295                 300


Ala Met Gly Val Ser Ala Leu Thr His Ser Pro Ser Ser Ser Ser Ile 
305                 310                 315                 320


Ser Ser Val Ser Ser Val Ala Ser Ser Val Gly Gly Arg Pro Ser Arg 
                325                 330                 335


Ser Gly Leu Leu Thr Glu Thr Ser Ser Arg Tyr Ala Arg Lys Ile Ser 
            340                 345                 350


Gly Thr Thr Ala Leu Gln Glu Ala Leu Lys Glu Lys Gln Gln His Ile 
        355                 360                 365


Glu Gln Leu Leu Ala Glu Arg Asp Leu Glu Arg Ala Glu Val Ala Lys 
    370                 375                 380


Ala Thr Ser His Ile Cys Glu Val Glu Lys Glu Ile Ala Leu Leu Lys 
385                 390                 395                 400


Ala Gln His Glu Gln Tyr Val Ala Glu Ala Glu Glu Lys Leu Gln Arg 
                405                 410                 415


Ala Arg Leu Leu Val Glu Ser Val Arg Lys Glu Lys Val Asp Leu Ser 
            420                 425                 430


Asn Gln Leu Glu Glu Glu Arg Arg Lys Val Glu Asp Leu Gln Phe Arg 
        435                 440                 445


Val Glu Glu Glu Ser Ile Thr Lys Gly Asp Leu Glu Thr Gln Thr Gln 
    450                 455                 460


Leu Glu His Ala Arg Ile Gly Glu Leu Glu Gln Ser Leu Leu Leu Glu 
465                 470                 475                 480


Lys Ala Gln Ala Glu Arg Leu Leu Arg Glu Leu Ala Asp Asn Arg Leu 
                485                 490                 495


Thr Thr Val Ala Glu Lys Ser Arg Val Leu Gln Leu Glu Glu Glu Leu 
            500                 505                 510


Thr Leu Arg Arg Gly Glu Ile Glu Glu Leu Gln Gln Cys Leu Leu His 
        515                 520                 525


Ser Gly Pro Pro Pro Pro Asp His Pro Asp Ala Ala Glu Ile Leu Arg 
    530                 535                 540


Leu Arg Glu Arg Leu Leu Ser Ala Ser Lys Glu His Gln Arg Glu Ser 
545                 550                 555                 560


Gly Val Leu Arg Asp Lys Tyr Glu Lys Ala Leu Lys Ala Tyr Gln Ala 
                565                 570                 575


Glu Val Asp Lys Leu Arg Ala Ala Asn Glu Lys Tyr Ala Gln Glu Val 
            580                 585                 590


Ala Gly Leu Lys Asp Lys Val Gln Gln Ala Thr Ser Glu Asn Met Gly 
        595                 600                 605


Leu Met Asp Asn Trp Lys Ser Lys Leu Asp Ser Leu Ala Ser Asp His 
    610                 615                 620


Gln Lys Ser Leu Glu Asp Leu Lys Ala Thr Leu Asn Ser Gly Pro Gly 
625                 630                 635                 640


Ala Gln Gln Lys Glu Ile Gly Glu Leu Lys Ala Val Met Glu Gly Ile 
                645                 650                 655


Lys Met Glu His Gln Leu Glu Leu Gly Asn Leu Gln Ala Lys His Asp 
            660                 665                 670


Leu Glu Thr Ala Met His Val Lys Glu Lys Glu Ala Leu Arg Glu Lys 
        675                 680                 685


Leu Gln Glu Ala Gln Glu Glu Leu Ala Gly Leu Gln Arg His Trp Arg 
    690                 695                 700


Ala Gln Leu Glu Val Gln Ala Ser Gln His Arg Leu Glu Leu Gln Glu 
705                 710                 715                 720


Ala Gln Asp Gln Arg Arg Asp Ala Glu Leu Arg Val His Glu Leu Glu 
                725                 730                 735


Lys Leu Asp Val Glu Tyr Arg Gly Gln Ala Gln Ala Ile Glu Phe Leu 
            740                 745                 750


Lys Glu Gln Ile Ser Leu Ala Glu Lys Lys Met Leu Asp Tyr Glu Arg 
        755                 760                 765


Leu Gln Arg Ala Glu Ala Gln Gly Lys Gln Glu Val Glu Ser Leu Arg 
    770                 775                 780


Glu Lys Leu Leu Val Ala Glu Asn Arg Leu Gln Ala Val Glu Ala Leu 
785                 790                 795                 800


Cys Ser Ser Gln His Thr His Met Ile Glu Ser Asn Asp Ile Ser Glu 
                805                 810                 815


Glu Thr Ile Arg Thr Lys Glu Thr Val Glu Gly Leu Gln Asp Lys Leu 
            820                 825                 830


Asn Lys Arg Asp Lys Glu Val Thr Ala Leu Thr Ser Gln Thr Glu Met 
        835                 840                 845


Leu Arg Ala Gln Val Ser Ala Leu Glu Ser Lys Cys Lys Ser Gly Glu 
    850                 855                 860


Lys Lys Val Asp Ala Leu Leu Lys Glu Lys Arg Arg Leu Glu Ala Glu 
865                 870                 875                 880


Leu Glu Thr Val Ser Arg Lys Thr His Asp Ala Ser Gly Gln Leu Val 
                885                 890                 895


Leu Ile Ser Gln Glu Leu Leu Arg Lys Glu Arg Ser Leu Asn Glu Leu 
            900                 905                 910


Arg Val Leu Leu Leu Glu Ala Asn Arg His Ser Pro Gly Pro Glu Arg 
        915                 920                 925


Asp Leu Ser Arg Glu Val His Lys Ala Glu Trp Arg Ile Lys Glu Gln 
    930                 935                 940


Lys Leu Lys Asp Asp Ile Arg Gly Leu Arg Glu Lys Leu Thr Gly Leu 
945                 950                 955                 960


Asp Lys Glu Lys Ser Leu Ser Asp Gln Arg Arg Tyr Ser Leu Ile Asp 
                965                 970                 975


Arg Ser Ser Ala Pro Glu Leu Leu Arg Leu Gln His Gln Leu Met Ser 
            980                 985                 990


Thr Glu Asp Ala Leu Arg Asp Ala Leu Asp Gln Ala Gln Gln Val Glu 
        995                 1000                1005


Lys Leu Met Glu Ala Met Arg Ser Cys Pro Asp Lys Ala Gln Thr Ile 
    1010                1015                1020


Gly Asn Ser Gly Ser Ala Asn Gly Ile His Gln Gln Asp Lys Ala Gln 
1025                1030                1035                1040


Lys Gln Glu Asp Lys His 
                1045


<210>  3990
<211>  245
<212>  DNA
<213>  Homo sapiens

<400>  3990
gctcacggag acctcttcac gctacgcccg caagatctcg ggcaccacgg ccttgcagga     60

ggcactgaag gagaagcagc agcacattga gcagctgctg gctgaacgag acctggaacg    120

ggctgaggtg gccaaggcca caagccacat ctgcgaggtg gagaaggaga ttgccctgct    180

caagtggaat tgttgaagtg tggcgagtct gtgctcggga caataaagct tgtgacaggt    240

ccagg                                                                245


<210>  3991
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  3991

Leu Thr Glu Thr Ser Ser Arg Tyr Ala Arg Lys Ile Ser Gly Thr Thr 
1               5                   10                  15


Ala Leu Gln Glu Ala Leu Lys Glu Lys Gln Gln His Ile Glu Gln Leu 
            20                  25                  30


Leu Ala Glu Arg Asp Leu Glu Arg Ala Glu Val Ala Lys Ala Thr Ser 
        35                  40                  45


His Ile Cys Glu Val Glu Lys Glu Ile Ala Leu Leu Lys Trp Asn Cys 
    50                  55                  60


<210>  3992
<211>  551
<212>  DNA
<213>  Homo sapiens

<400>  3992
ctggagtgag gaagaacttg gaccctggag gccaagtgtg accccgtcac agagctcctg     60

tgggagggcc atggccctac ccactgctgc tttggtccag gagcattgat gcttctcgtc    120

tctcctctct cccctaggcc tgcaggacaa gctgaacaag agggacaaag aggtgacagc    180

cttgacctcc cagaccgaga tgctcagggc ccaagtaagt gcgctggaga gcaagtgtaa    240

gtcaggcgag aagaaggtgg acgccctcct gaaggagaag cggcgcctgg aggcagagct    300

ggagaccgtg tcccggaaga cccatgacgc ctcgggccag ctagtcctca tcagccagga    360

gctgctgcgg aaggagcggt gaggcggccg tggggccggc tgggtcctcc ctgtggccct    420

ggcccttgct cctcttcttg acattagctc atgttatctt ggggcagaga gggggataga    480

gctggtgggc caggtggccg atctcgagcg atcaccctgc tctcctctaa gctccgataa    540

agtctccaaa g                                                         551


<210>  3993
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  3993

Met Leu Arg Ala Gln Val Ser Ala Leu Glu Ser Lys Cys Lys Ser Gly 
1               5                   10                  15


Glu Lys Lys Val Asp Ala Leu Leu Lys Glu Lys Arg Arg Leu Glu Ala 
            20                  25                  30


Glu Leu Glu Thr Val Ser Arg Lys Thr His Asp Ala Ser Gly Gln Leu 
        35                  40                  45


Val Leu Ile Ser Gln Glu Leu Leu Arg Lys Glu Arg 
    50                  55                  60


<210>  3994
<211>  588
<212>  DNA
<213>  Homo sapiens

<400>  3994
cggggacctt cagcctggac acccggcagc ttctggagtt tgtcagtgga ggcagagggg     60

atccggccag gcccctctgt ccagaaggag ctgccctgag gaccatctta gcggccctgt    120

cctctttttc cgcccattct ccctcgggtc tccccagagg ggccggcggg ggctggggag    180

ggggtaagtt tatccatgca ttctattaac agccgtctag aagcgatgct ttagtggcct    240

aacccagggt caaatacagc tctttctagc aaaatcaggc agctctgccc catcggtagg    300

ggcaccgatt agtctactaa cagccagagg tccatctagc agggtgccgg gaggagctga    360

gcccccggag gtgggctcct ggtgacgggt gtccaagaag cggtttcctt gggagcttct    420

gcctccgtgg gcctctcagc ccgccccgtg tggccgcccg ggtgtggctc agccatgtcc    480

cctccccagg tccttcattc acccctcccc tccccacagt ggaattgttg aagtgtggcg    540

agtctgtgct cgggacaata aagcttgtga caggtccagg accccggc                 588


<210>  3995
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  3995

Gly Thr Phe Ser Leu Asp Thr Arg Gln Leu Leu Glu Phe Val Ser Gly 
1               5                   10                  15


Gly Arg Gly Asp Pro Ala Arg Pro Leu Cys Pro Glu Gly Ala Ala Leu 
            20                  25                  30


Arg Thr Ile Leu Ala Ala Leu Ser Ser Phe Ser Ala His Ser Pro Ser 
        35                  40                  45


Gly Leu Pro Arg Gly Ala Gly Gly Gly Trp Gly Gly Gly Lys Phe Ile 
    50                  55                  60


His Ala Phe Tyr 
65


<210>  3996
<211>  3445
<212>  DNA
<213>  Homo sapiens

<400>  3996
taaatggcag ccaatggagg gtggtgttgc gcggggctgg gattagggcc ggggcgaatg     60

gctggcaatc ttactgggat tacagaacaa agagcctccc cgcgctcccg ctctccgctc    120

ctctccccgc gccgccccgc cctccgccgc agcccgcgcc gggggtgggg gccgccgagc    180

gccagccccc cggccggccg attccccccc cgcgccccct ccccgcgcct ccctccccgc    240

cctcgccgcg ccgccgtcct cgcctccctc tgcctctcct tcccccattc tcccggatta    300

attaaggagg cagcggcagg aggctgagtc ctggccgcgg gccggggccg gggcgccgct    360

ggcaggagcg cttggggatc ctccaaggcg accatggcct tgctgggtaa gcgctgtgac    420

gtccccacca acggctgcgg acccgaccgc tggaactccg cgttcacccg caaagacgag    480

atcatcacca gcctcgtgtc tgccttagac tccatgtgct cagcgctgtc caaactgaac    540

gccgaggtgg cctgtgtcgc cgtgcacgat gagagcgcct ttgtggtggg cacagagaag    600

gggagaatgt tcctgaatgc ccggaaggag ctacagtcag acttcctcag gttctgccga    660

gggcccccgt ggaaggatcc ggaggcagag caccccaaga aggtgcagcg gggcgagggt    720

ggaggccgta gcctccctcg gtcctccctg gaacatggct cagatgtgta ccttctgcgg    780

aagatggtag aggaggtgtt tgatgttctt tatagcgagg ccctgggaag ggccagtgtg    840

gtgccactgc cctatgagag gctgctcagg gagccagggc tgctggccgt gcaggggctg    900

cccgaaggcc tggccttccg aaggccagcc gagtatgacc ccaaggccct catggccatc    960

ctggaacaca gccaccgcat ccgcttcaag ctcaagaggc cacttgagga tggcgggcgg   1020

gactcgaagg ccctggtgga gctgaacggt gtctccctga ttcccaaggg gtcacgggac   1080

tgtggcctgc atggccaggc ccccaaggtg ccaccccagg acctgccccc aaccgccacc   1140

tcctcctcca tggccagctt cctgtacagc acggcgctcc ccaaccacgc catccgagag   1200

ctcaagcagg aagcaccttc ctgccccctt gcccccagcg acctgggcct gagtcggccc   1260

atgccagagc ccaaggccac cggtgcccaa gacttctccg actgttgtgg acagaagccc   1320

actgggcctg gtgggcctct catccagaac gtccatgcct ccaagcgcat tctcttctcc   1380

atcgtccatg acaagtcaga gaagtgggac gccttcataa aggaaaccga ggacatcaac   1440

acgctccggg agtgtgtgca gatcctgttt aacagcagat atgcggaagc cctgggcctg   1500

gaccacatgg tccccgtgcc ctaccggaag attgcctgtg acccggaggc tgtggagatc   1560

gtgggcatcc cggacaagat ccccttcaag cgcccctgca cttatggagt ccccaagctg   1620

aagcggatcc tggaggagcg ccatagtatc cacttcatca ttaagaggat gtttgatgag   1680

cgaattttca cagggaacaa gtttaccaaa gacaccacga agctggagcc agccagcccg   1740

ccagaggaca cctctgcaga ggtctctagg gccaccgtcc ttgaccttgc tgggaatgct   1800

cggtcagaca agggcagcat gtctgaagac tgtgggccag gaacctccgg ggagctgggc   1860

gggctgaggc cgatcaaaat tgagccagag gatctggaca tcattcaggt caccgtccca   1920

gacccctcgc caacctctga ggaaatgaca gactcgatgc ctgggcacct gccatcggag   1980

gattctggtt atgggatgga gatgctgaca gacaaaggtc tgagtgagga cgcgcggccc   2040

gaggagaggc ccgtggagga cagccacggt gacgtgatcc ggcccctgcg gaagcaggtg   2100

gagctgctct tcaacacacg atacgccaag gccattggca tctcggagcc cgtcaaggtg   2160

ccgtactcca agtttctgat gcacccggag gagctgtttg tggtgggact gcctgaaggc   2220

atctccctcc gcaggcccaa ctgcttcggg atcgccaagc tccggaagat tctggaggcc   2280

agcaacagca tccagtttgt catcaagagg cccgagctgc tcactgaggg agtcaaagag   2340

cccatcatgg atagtcaagg aactgcctcc tcacttggct tctctccccc tgccctgccc   2400

ccagagaggg attccgggga ccctctggtg gacgagagcc tgaagagaca gggctttcaa   2460

gaaaattatg acgcgaggct ctcacggatc gacatcgcca acacactaag ggagcaggtc   2520

caggaccttt tcaataagaa atacggggaa gccttgggca tcaagtaccc ggtccaggtc   2580

ccctacaagc ggatcaagag taaccccggc tccgtgatca tcgaggggct gcccccagga   2640

atcccgttcc gaaagccctg taccttcggc tcccagaacc tggagaggat tcttgctgtg   2700

gctgacaaga tcaagttcac agtcaccagg cctttccaag gactcatccc aaagcctgat   2760

gaagatgacg ccaacagact cggggagaag gtgatcctgc gggagcaggt gaaggaactc   2820

ttcaacgaga aatacggtga ggccctgggc ctgaaccggc cggtgctggt cccttataaa   2880

ctaatccggg acagcccaga cgccgtggag gtcacgggtc tgcctgatga catccccttc   2940

cggaacccca acacgtacga catccaccgg ctggagaaga tcctgaaggc ccgagagcat   3000

gtccgcatgg tcatcattaa ccagctccaa ccctttgcag aaatctgcaa tgatgccaag   3060

gtgccagcca aagacagcag cattcccaag cgcaagagaa agcgggtctc ggaaggaaat   3120

tccgtctcct cttcctcctc gtcttcctct tcctcgtcct ctaacccgga ttcagtggca   3180

tcggccaacc agatctcact cgtgcaatgg ccaatgtaca tggtggacta tgccggcctg   3240

aacgtgcagc tcccgggacc tcttaattac tagacctcag tactgaatca ggacctcact   3300

cagaaagact aaaggaaatg taatttatgt acaaaatgta tattcggata tgtatcgatg   3360

ccttttagtt tttccaatga tttttacact atattcctgc caccaaggcc tttttaaata   3420

agtaaaaaaa gaaaaaaaaa aaaag                                         3445


<210>  3997
<211>  959
<212>  PRT
<213>  Homo sapiens

<400>  3997

Met Ala Leu Leu Gly Lys Arg Cys Asp Val Pro Thr Asn Gly Cys Gly 
1               5                   10                  15


Pro Asp Arg Trp Asn Ser Ala Phe Thr Arg Lys Asp Glu Ile Ile Thr 
            20                  25                  30


Ser Leu Val Ser Ala Leu Asp Ser Met Cys Ser Ala Leu Ser Lys Leu 
        35                  40                  45


Asn Ala Glu Val Ala Cys Val Ala Val His Asp Glu Ser Ala Phe Val 
    50                  55                  60


Val Gly Thr Glu Lys Gly Arg Met Phe Leu Asn Ala Arg Lys Glu Leu 
65                  70                  75                  80


Gln Ser Asp Phe Leu Arg Phe Cys Arg Gly Pro Pro Trp Lys Asp Pro 
                85                  90                  95


Glu Ala Glu His Pro Lys Lys Val Gln Arg Gly Glu Gly Gly Gly Arg 
            100                 105                 110


Ser Leu Pro Arg Ser Ser Leu Glu His Gly Ser Asp Val Tyr Leu Leu 
        115                 120                 125


Arg Lys Met Val Glu Glu Val Phe Asp Val Leu Tyr Ser Glu Ala Leu 
    130                 135                 140


Gly Arg Ala Ser Val Val Pro Leu Pro Tyr Glu Arg Leu Leu Arg Glu 
145                 150                 155                 160


Pro Gly Leu Leu Ala Val Gln Gly Leu Pro Glu Gly Leu Ala Phe Arg 
                165                 170                 175


Arg Pro Ala Glu Tyr Asp Pro Lys Ala Leu Met Ala Ile Leu Glu His 
            180                 185                 190


Ser His Arg Ile Arg Phe Lys Leu Lys Arg Pro Leu Glu Asp Gly Gly 
        195                 200                 205


Arg Asp Ser Lys Ala Leu Val Glu Leu Asn Gly Val Ser Leu Ile Pro 
    210                 215                 220


Lys Gly Ser Arg Asp Cys Gly Leu His Gly Gln Ala Pro Lys Val Pro 
225                 230                 235                 240


Pro Gln Asp Leu Pro Pro Thr Ala Thr Ser Ser Ser Met Ala Ser Phe 
                245                 250                 255


Leu Tyr Ser Thr Ala Leu Pro Asn His Ala Ile Arg Glu Leu Lys Gln 
            260                 265                 270


Glu Ala Pro Ser Cys Pro Leu Ala Pro Ser Asp Leu Gly Leu Ser Arg 
        275                 280                 285


Pro Met Pro Glu Pro Lys Ala Thr Gly Ala Gln Asp Phe Ser Asp Cys 
    290                 295                 300


Cys Gly Gln Lys Pro Thr Gly Pro Gly Gly Pro Leu Ile Gln Asn Val 
305                 310                 315                 320


His Ala Ser Lys Arg Ile Leu Phe Ser Ile Val His Asp Lys Ser Glu 
                325                 330                 335


Lys Trp Asp Ala Phe Ile Lys Glu Thr Glu Asp Ile Asn Thr Leu Arg 
            340                 345                 350


Glu Cys Val Gln Ile Leu Phe Asn Ser Arg Tyr Ala Glu Ala Leu Gly 
        355                 360                 365


Leu Asp His Met Val Pro Val Pro Tyr Arg Lys Ile Ala Cys Asp Pro 
    370                 375                 380


Glu Ala Val Glu Ile Val Gly Ile Pro Asp Lys Ile Pro Phe Lys Arg 
385                 390                 395                 400


Pro Cys Thr Tyr Gly Val Pro Lys Leu Lys Arg Ile Leu Glu Glu Arg 
                405                 410                 415


His Ser Ile His Phe Ile Ile Lys Arg Met Phe Asp Glu Arg Ile Phe 
            420                 425                 430


Thr Gly Asn Lys Phe Thr Lys Asp Thr Thr Lys Leu Glu Pro Ala Ser 
        435                 440                 445


Pro Pro Glu Asp Thr Ser Ala Glu Val Ser Arg Ala Thr Val Leu Asp 
    450                 455                 460


Leu Ala Gly Asn Ala Arg Ser Asp Lys Gly Ser Met Ser Glu Asp Cys 
465                 470                 475                 480


Gly Pro Gly Thr Ser Gly Glu Leu Gly Gly Leu Arg Pro Ile Lys Ile 
                485                 490                 495


Glu Pro Glu Asp Leu Asp Ile Ile Gln Val Thr Val Pro Asp Pro Ser 
            500                 505                 510


Pro Thr Ser Glu Glu Met Thr Asp Ser Met Pro Gly His Leu Pro Ser 
        515                 520                 525


Glu Asp Ser Gly Tyr Gly Met Glu Met Leu Thr Asp Lys Gly Leu Ser 
    530                 535                 540


Glu Asp Ala Arg Pro Glu Glu Arg Pro Val Glu Asp Ser His Gly Asp 
545                 550                 555                 560


Val Ile Arg Pro Leu Arg Lys Gln Val Glu Leu Leu Phe Asn Thr Arg 
                565                 570                 575


Tyr Ala Lys Ala Ile Gly Ile Ser Glu Pro Val Lys Val Pro Tyr Ser 
            580                 585                 590


Lys Phe Leu Met His Pro Glu Glu Leu Phe Val Val Gly Leu Pro Glu 
        595                 600                 605


Gly Ile Ser Leu Arg Arg Pro Asn Cys Phe Gly Ile Ala Lys Leu Arg 
    610                 615                 620


Lys Ile Leu Glu Ala Ser Asn Ser Ile Gln Phe Val Ile Lys Arg Pro 
625                 630                 635                 640


Glu Leu Leu Thr Glu Gly Val Lys Glu Pro Ile Met Asp Ser Gln Gly 
                645                 650                 655


Thr Ala Ser Ser Leu Gly Phe Ser Pro Pro Ala Leu Pro Pro Glu Arg 
            660                 665                 670


Asp Ser Gly Asp Pro Leu Val Asp Glu Ser Leu Lys Arg Gln Gly Phe 
        675                 680                 685


Gln Glu Asn Tyr Asp Ala Arg Leu Ser Arg Ile Asp Ile Ala Asn Thr 
    690                 695                 700


Leu Arg Glu Gln Val Gln Asp Leu Phe Asn Lys Lys Tyr Gly Glu Ala 
705                 710                 715                 720


Leu Gly Ile Lys Tyr Pro Val Gln Val Pro Tyr Lys Arg Ile Lys Ser 
                725                 730                 735


Asn Pro Gly Ser Val Ile Ile Glu Gly Leu Pro Pro Gly Ile Pro Phe 
            740                 745                 750


Arg Lys Pro Cys Thr Phe Gly Ser Gln Asn Leu Glu Arg Ile Leu Ala 
        755                 760                 765


Val Ala Asp Lys Ile Lys Phe Thr Val Thr Arg Pro Phe Gln Gly Leu 
    770                 775                 780


Ile Pro Lys Pro Asp Glu Asp Asp Ala Asn Arg Leu Gly Glu Lys Val 
785                 790                 795                 800


Ile Leu Arg Glu Gln Val Lys Glu Leu Phe Asn Glu Lys Tyr Gly Glu 
                805                 810                 815


Ala Leu Gly Leu Asn Arg Pro Val Leu Val Pro Tyr Lys Leu Ile Arg 
            820                 825                 830


Asp Ser Pro Asp Ala Val Glu Val Thr Gly Leu Pro Asp Asp Ile Pro 
        835                 840                 845


Phe Arg Asn Pro Asn Thr Tyr Asp Ile His Arg Leu Glu Lys Ile Leu 
    850                 855                 860


Lys Ala Arg Glu His Val Arg Met Val Ile Ile Asn Gln Leu Gln Pro 
865                 870                 875                 880


Phe Ala Glu Ile Cys Asn Asp Ala Lys Val Pro Ala Lys Asp Ser Ser 
                885                 890                 895


Ile Pro Lys Arg Lys Arg Lys Arg Val Ser Glu Gly Asn Ser Val Ser 
            900                 905                 910


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Asn Pro Asp Ser Val 
        915                 920                 925


Ala Ser Ala Asn Gln Ile Ser Leu Val Gln Trp Pro Met Tyr Met Val 
    930                 935                 940


Asp Tyr Ala Gly Leu Asn Val Gln Leu Pro Gly Pro Leu Asn Tyr 
945                 950                 955


<210>  3998
<211>  3304
<212>  DNA
<213>  Homo sapiens

<400>  3998
gccgccgagc gccagccccc cggccggccg attccccccc cgcgccccct ccccgcgcct     60

ccctccccgc cctcgccgcg ccgccgtcct cgcctccctc tgcctctcct tcccccattc    120

tcccggatta attaaggagg cagcggcagg aggctgagtc ctggccgcgg gccggggccg    180

gggcgccgct ggcaggagcg cttggggatc ctccaaggcg accatggcct tgctgggtaa    240

gcgctgtgac gtccccacca acggctgcgg acccgaccgc tggaactccg cgttcacccg    300

caaagacgag atcatcacca gcctcgtgtc tgccttagac tccatgtgct cagcgctgtc    360

caaactgaac gccgaggtgg cctgtgtcgc cgtgcacgat gagagcgcct ttgtggtggg    420

cacagagaag gggagaatgt tcctgaatgc ccggaaggag ctacagtcag acttcctcag    480

gttctgcctc tccgcagctc agcacagggc agcgacatcc cagctcgaag gccgggtggt    540

gagacgggtg ctcactgtgg cctcgcgtgc tctgtgtccc acaggagggc ccccgtggaa    600

ggatccggag gcagagcacc ccaagaaggt gcagcggggc gagggtggag gccgtagcct    660

ccctcggtcc tccctggaac atggctcaga tgtgtacctt ctgcggaaga tggtagagga    720

ggtgtttgat gttctttata gcgaggccct gggaagggcc agtgtggtgc cactgcccta    780

tgagaggctg ctcagggagc cagggctgct ggccgtgcag gggctgcccg aaggcctggc    840

cttccgaagg ccagccgagt atgaccccaa ggccctcatg gccatcctgg aacacagcca    900

ccgcatccgc ttcaagctca agaggccact tgaggatggc gggcgggact cgaaggccct    960

ggtggagctg aacggtgtct ccctgattcc caaggggtca cgggactgtg gcctgcatgg   1020

ccaggccccc aaggtgccac cccaggacct gcccccaacc gccacctcct cctccatggc   1080

cagcttcctg tacagcacgg cgctccccaa ccacgccatc cgagagctca agcaggaagc   1140

accttcctgc ccccttgccc ccagcgacct gggcctgagt cggcccatgc cagagcccaa   1200

ggccaccggt gcccaagact tctccgactg ttgtggacag aagcccactg ggcctggtgg   1260

gcctctcatc cagaacgtcc atgcctccaa gcgcattctc ttctccatcg tccatgacaa   1320

gtcagagaag tgggacgcct tcataaagga aaccgaggac atcaacacgc tccgggagtg   1380

tgtgcagatc ctgtttaaca gcagatatgc ggaagccctg ggcctggacc acatggtccc   1440

cgtgccctac cggaagattg cctgtgaccc ggaggctgtg gagatcgtgg gcatcccgga   1500

caagatcccc ttcaagcgcc cctgcactta tggagtcccc aagctgaagc ggatcctgga   1560

ggagcgccat agtatccact tcatcattaa gaggatgttt gatgagcgaa ttttcacagg   1620

gaacaagttt accaaagaca ccacgaagct ggagccagcc agcccgccag aggacacctc   1680

tgcagaggtc tctagggcca ccgtccttga ccttgctggg aatgctcggt cagacaaggg   1740

cagcatgtct gaagactgtg ggccaggaac ctccggggag ctgggcgggc tgaggccgat   1800

caaaattgag ccagaggatc tggacatcat tcaggtcacc gtcccagacc cctcgccaac   1860

ctctgaggaa atgacagact cgatgcctgg gcacctgcca tcggaggatt ctggttatgg   1920

gatggagatg ctgacagaca aaggtctgag tgaggacgcg cggcccgagg agaggcccgt   1980

ggaggacagc cacggtgacg tgatccggcc cctgcggaag caggtggagc tgctcttcaa   2040

cacacgatac gccaaggcca ttggcatctc ggagcccgtc aaggtgccgt actccaagtt   2100

tctgatgcac ccggaggagc tgtttgtggt gggactgcct gaaggcatct ccctccgcag   2160

gcccaactgc ttcgggatcg ccaagctccg gaagattctg gaggccagca acagcatcca   2220

gtttgtcatc aagaggcccg agctgctcac tgagggagtc aaagagccca tcatggatag   2280

tcaagagagg gattccgggg accctctggt ggacgagagc ctgaagagac agggctttca   2340

agaaaattat gacgcgaggc tctcacggat cgacatcgcc aacacactaa gggagcaggt   2400

ccaggacctt ttcaataaga aatacgggga agccttgggc atcaagtacc cggtccaggt   2460

cccctacaag cggatcaaga gtaaccccgg ctccgtgatc atcgaggggc tgcccccagg   2520

aatcccgttc cgaaagccct gtaccttcgg ctcccagaac ctggagagga ttcttgctgt   2580

ggctgacaag atcaagttca cagtcaccag gcctttccaa ggactcatcc caaagcctga   2640

tgaagatgac gccaacagac tcggggagaa ggtgatcctg cgggagcagg tgaaggaact   2700

cttcaacgag aaatacggtg aggccctggg cctgaaccgg ccggtgctgg tcccttataa   2760

actaatccgg gacagcccag acgccgtgga ggtcacgggt ctgcctgatg acatcccctt   2820

ccggaacccc aacacgtacg acatccaccg gctggagaag atcctgaagg cccgagagca   2880

tgtccgcatg gtcatcatta accagctcca accctttgca gaaatctgca atgatgccaa   2940

ggtgccagcc aaagacagca gcattcccaa gcgcaagaga aagcgggtct cggaaggaaa   3000

ttccgtctcc tcttcctcct cgtcttcctc ttcctcgtcc tctaacccgg attcagtggc   3060

atcggccaac cagatctcac tcgtgcaatg gccaatgtac atggtggact atgccggcct   3120

gaacgtgcag ctcccgggac ctcttaatta ctagacctca gtactgaatc aggacctcac   3180

tcagaaagac taaaggaaat gtaatttatg tacaaaatgt atattcggat atgtatcgat   3240

gccttttagt ttttccaatg atttttacac tatattcctg ccaccaaggc ctttttaaat   3300

aagt                                                                3304


<210>  3999
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  3999

Met Ala Leu Leu Gly Lys Arg Cys Asp Val Pro Thr Asn Gly Cys Gly 
1               5                   10                  15


Pro Asp Arg Trp Asn Ser Ala Phe Thr Arg Lys Asp Glu Ile Ile Thr 
            20                  25                  30


Ser Leu Val Ser Ala Leu Asp Ser Met Cys Ser Ala Leu Ser Lys Leu 
        35                  40                  45


Asn Ala Glu Val Ala Cys Val Ala Val His Asp Glu Ser Ala Phe Val 
    50                  55                  60


Val Gly Thr Glu Lys Gly Arg Met Phe Leu Asn Ala Arg Lys Glu Leu 
65                  70                  75                  80


Gln Ser Asp Phe Leu Arg Phe Cys Leu Ser Ala Ala Gln His Arg Ala 
                85                  90                  95


Ala Thr Ser Gln Leu Glu Gly Arg Val Val Arg Arg Val Leu Thr Val 
            100                 105                 110


Ala Ser Arg Ala Leu Cys Pro Thr Gly Gly Pro Pro Trp Lys Asp Pro 
        115                 120                 125


Glu Ala Glu His Pro Lys Lys Val Gln Arg Gly Glu Gly Gly Gly Arg 
    130                 135                 140


Ser Leu Pro Arg Ser Ser Leu Glu His Gly Ser Asp Val Tyr Leu Leu 
145                 150                 155                 160


Arg Lys Met Val Glu Glu Val Phe Asp Val Leu Tyr Ser Glu Ala Leu 
                165                 170                 175


Gly Arg Ala Ser Val Val Pro Leu Pro Tyr Glu Arg Leu Leu Arg Glu 
            180                 185                 190


Pro Gly Leu Leu Ala Val Gln Gly Leu Pro Glu Gly Leu Ala Phe Arg 
        195                 200                 205


Arg Pro Ala Glu Tyr Asp Pro Lys Ala Leu Met Ala Ile Leu Glu His 
    210                 215                 220


Ser His Arg Ile Arg Phe Lys Leu Lys Arg Pro Leu Glu Asp Gly Gly 
225                 230                 235                 240


Arg Asp Ser Lys Ala Leu Val Glu Leu Asn Gly Val Ser Leu Ile Pro 
                245                 250                 255


Lys Gly Ser Arg Asp Cys Gly Leu His Gly Gln Ala Pro Lys Val Pro 
            260                 265                 270


Pro Gln Asp Leu Pro Pro Thr Ala Thr Ser Ser Ser Met Ala Ser Phe 
        275                 280                 285


Leu Tyr Ser Thr Ala Leu Pro Asn His Ala Ile Arg Glu Leu Lys Gln 
    290                 295                 300


Glu Ala Pro Ser Cys Pro Leu Ala Pro Ser Asp Leu Gly Leu Ser Arg 
305                 310                 315                 320


Pro Met Pro Glu Pro Lys Ala Thr Gly Ala Gln Asp Phe Ser Asp Cys 
                325                 330                 335


Cys Gly Gln Lys Pro Thr Gly Pro Gly Gly Pro Leu Ile Gln Asn Val 
            340                 345                 350


His Ala Ser Lys Arg Ile Leu Phe Ser Ile Val His Asp Lys Ser Glu 
        355                 360                 365


Lys Trp Asp Ala Phe Ile Lys Glu Thr Glu Asp Ile Asn Thr Leu Arg 
    370                 375                 380


Glu Cys Val Gln Ile Leu Phe Asn Ser Arg Tyr Ala Glu Ala Leu Gly 
385                 390                 395                 400


Leu Asp His Met Val Pro Val Pro Tyr Arg Lys Ile Ala Cys Asp Pro 
                405                 410                 415


Glu Ala Val Glu Ile Val Gly Ile Pro Asp Lys Ile Pro Phe Lys Arg 
            420                 425                 430


Pro Cys Thr Tyr Gly Val Pro Lys Leu Lys Arg Ile Leu Glu Glu Arg 
        435                 440                 445


His Ser Ile His Phe Ile Ile Lys Arg Met Phe Asp Glu Arg Ile Phe 
    450                 455                 460


Thr Gly Asn Lys Phe Thr Lys Asp Thr Thr Lys Leu Glu Pro Ala Ser 
465                 470                 475                 480


Pro Pro Glu Asp Thr Ser Ala Glu Val Ser Arg Ala Thr Val Leu Asp 
                485                 490                 495


Leu Ala Gly Asn Ala Arg Ser Asp Lys Gly Ser Met Ser Glu Asp Cys 
            500                 505                 510


Gly Pro Gly Thr Ser Gly Glu Leu Gly Gly Leu Arg Pro Ile Lys Ile 
        515                 520                 525


Glu Pro Glu Asp Leu Asp Ile Ile Gln Val Thr Val Pro Asp Pro Ser 
    530                 535                 540


Pro Thr Ser Glu Glu Met Thr Asp Ser Met Pro Gly His Leu Pro Ser 
545                 550                 555                 560


Glu Asp Ser Gly Tyr Gly Met Glu Met Leu Thr Asp Lys Gly Leu Ser 
                565                 570                 575


Glu Asp Ala Arg Pro Glu Glu Arg Pro Val Glu Asp Ser His Gly Asp 
            580                 585                 590


Val Ile Arg Pro Leu Arg Lys Gln Val Glu Leu Leu Phe Asn Thr Arg 
        595                 600                 605


Tyr Ala Lys Ala Ile Gly Ile Ser Glu Pro Val Lys Val Pro Tyr Ser 
    610                 615                 620


Lys Phe Leu Met His Pro Glu Glu Leu Phe Val Val Gly Leu Pro Glu 
625                 630                 635                 640


Gly Ile Ser Leu Arg Arg Pro Asn Cys Phe Gly Ile Ala Lys Leu Arg 
                645                 650                 655


Lys Ile Leu Glu Ala Ser Asn Ser Ile Gln Phe Val Ile Lys Arg Pro 
            660                 665                 670


Glu Leu Leu Thr Glu Gly Val Lys Glu Pro Ile Met Asp Ser Gln Glu 
        675                 680                 685


Arg Asp Ser Gly Asp Pro Leu Val Asp Glu Ser Leu Lys Arg Gln Gly 
    690                 695                 700


Phe Gln Glu Asn Tyr Asp Ala Arg Leu Ser Arg Ile Asp Ile Ala Asn 
705                 710                 715                 720


Thr Leu Arg Glu Gln Val Gln Asp Leu Phe Asn Lys Lys Tyr Gly Glu 
                725                 730                 735


Ala Leu Gly Ile Lys Tyr Pro Val Gln Val Pro Tyr Lys Arg Ile Lys 
            740                 745                 750


Ser Asn Pro Gly Ser Val Ile Ile Glu Gly Leu Pro Pro Gly Ile Pro 
        755                 760                 765


Phe Arg Lys Pro Cys Thr Phe Gly Ser Gln Asn Leu Glu Arg Ile Leu 
    770                 775                 780


Ala Val Ala Asp Lys Ile Lys Phe Thr Val Thr Arg Pro Phe Gln Gly 
785                 790                 795                 800


Leu Ile Pro Lys Pro Asp Glu Asp Asp Ala Asn Arg Leu Gly Glu Lys 
                805                 810                 815


Val Ile Leu Arg Glu Gln Val Lys Glu Leu Phe Asn Glu Lys Tyr Gly 
            820                 825                 830


Glu Ala Leu Gly Leu Asn Arg Pro Val Leu Val Pro Tyr Lys Leu Ile 
        835                 840                 845


Arg Asp Ser Pro Asp Ala Val Glu Val Thr Gly Leu Pro Asp Asp Ile 
    850                 855                 860


Pro Phe Arg Asn Pro Asn Thr Tyr Asp Ile His Arg Leu Glu Lys Ile 
865                 870                 875                 880


Leu Lys Ala Arg Glu His Val Arg Met Val Ile Ile Asn Gln Leu Gln 
                885                 890                 895


Pro Phe Ala Glu Ile Cys Asn Asp Ala Lys Val Pro Ala Lys Asp Ser 
            900                 905                 910


Ser Ile Pro Lys Arg Lys Arg Lys Arg Val Ser Glu Gly Asn Ser Val 
        915                 920                 925


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Asn Pro Asp Ser 
    930                 935                 940


Val Ala Ser Ala Asn Gln Ile Ser Leu Val Gln Trp Pro Met Tyr Met 
945                 950                 955                 960


Val Asp Tyr Ala Gly Leu Asn Val Gln Leu Pro Gly Pro Leu Asn Tyr 
                965                 970                 975


<210>  4000
<211>  3196
<212>  DNA
<213>  Homo sapiens

<400>  4000
cccccccgcg ccccctcccc gcgcctccct ccccgccctc gccgcgccgc cgtcctcgcc     60

tccctctgcc tctccttccc ccattctccc ggattaatta aggaggcagc ggcaggaggc    120

tgagtcctgg ccgcgggccg gggccggggc gccgctggca ggagcgcttg gggatcctcc    180

aaggcgacca tggccttgct gggtaagcgc tgtgacgtcc ccaccaacgg ctgcggaccc    240

gaccgctgga actccgcgtt cacccgcaaa gacgagatca tcaccagcct cgtgtctgcc    300

ttagactcca tgtgctcagc gctgtccaaa ctgaacgccg aggtggcctg tgtcgccgtg    360

cacgatgaga gcgcctttgt ggtgggcaca gagaagggga gaatgttcct gaatgcccgg    420

aaggagctac agtcagactt cctcaggttc tgccgagggc ccccgtggaa ggatccggag    480

gcagagcacc ccaagaaggt gcagcggggc gagggtggag gccgtagcct ccctcggtcc    540

tccctggaac atggctcaga tgtgtacctt ctgcggaaga tggtagagga ggtgtttgat    600

gttctttata gcgaggccct gggaagggcc agtgtggtgc cactgcccta tgagaggctg    660

ctcagggagc cagggctgct ggccgtgcag gggctgcccg aaggcctggc cttccgaagg    720

ccagccgagt atgaccccaa ggccctcatg gccatcctgg aacacagcca ccgcatccgc    780

ttcaagctca agaggccact tgaggatggc gggcgggact cgaaggccct ggtggagctg    840

aacggtgtct ccctgattcc caaggggtca cgggactgtg gcctgcatgg ccaggccccc    900

aaggtgccac cccaggacct gcccccaacc gccacctcct cctccatggc cagcttcctg    960

tacagcacgg cgctccccaa ccacgccatc cgagagctca agcaggaagc accttcctgc   1020

ccccttgccc ccagcgacct gggcctgagt cggcccatgc cagagcccaa ggccaccggt   1080

gcccaagact tctccgactg ttgtggacag aagcccactg ggcctggtgg gcctctcatc   1140

cagaacgtcc atgcctccaa gcgcattctc ttctccatcg tccatgacaa gtcagagaag   1200

tgggacgcct tcataaagga aaccgaggac atcaacacgc tccgggagtg tgtgcagatc   1260

ctgtttaaca gcagatatgc ggaagccctg ggcctggacc acatggtccc cgtgccctac   1320

cggaagattg cctgtgaccc ggaggctgtg gagatcgtgg gcatcccgga caagatcccc   1380

ttcaagcgcc cctgcactta tggagtcccc aagctgaagc ggatcctgga ggagcgccat   1440

agtatccact tcatcattaa gaggatgttt gatgagcgaa ttttcacagg gaacaagttt   1500

accaaagaca ccacgaagct ggagccagcc agcccgccag aggacacctc tgcagaggtc   1560

tctagggcca ccgtccttga ccttgctggg aatgctcggt cagacaaggg cagcatgtct   1620

gaagactgtg ggccaggaac ctccggggag ctgggcgggc tgaggccgat caaaattgag   1680

ccagaggatc tggacatcat tcaggtcacc gtcccagacc cctcgccaac ctctgaggaa   1740

atgacagact cgatgcctgg gcacctgcca tcggaggatt ctggttatgg gatggagatg   1800

ctgacagaca aaggtctgag tgaggacgcg cggcccgagg agaggcccgt ggaggacagc   1860

cacggtgacg tgatccggcc cctgcggaag caggtggagc tgctcttcaa cacacgatac   1920

gccaaggcca ttggcatctc ggagcccgtc aaggtgccgt actccaagtt tctgatgcac   1980

ccggaggagc tgtttgtggt gggactgcct gaaggcatct ccctccgcag gcccaactgc   2040

ttcgggatcg ccaagctccg gaagattctg gaggccagca acagcatcca gtttgtcatc   2100

aagaggcccg agctgctcac tgagggagtc aaagagccca tcatggatag tcaagagagg   2160

gattccgggg accctctggt ggacgagagc ctgaagagac agggctttca agaaaattat   2220

gacgcgaggc tctcacggat cgacatcgcc aacacactaa gggagcaggt ccaggacctt   2280

ttcaataaga aatacgggga agccttgggc atcaagtacc cggtccaggt cccctacaag   2340

cggatcaaga gtaaccccgg ctccgtgatc atcgaggggc tgcccccagg aatcccgttc   2400

cgaaagccct gtaccttcgg ctcccagaac ctggagagga ttcttgctgt ggctgacaag   2460

atcaagttca cagtcaccag gcctttccaa ggactcatcc caaagcctga tgaagatgac   2520

gccaacagac tcggggagaa ggtgatcctg cgggagcagg tgaaggaact cttcaacgag   2580

aaatacggtg aggccctggg cctgaaccgg ccggtgctgg tcccttataa actaatccgg   2640

gacagcccag acgccgtgga ggtcacgggt ctgcctgatg acatcccctt ccggaacccc   2700

aacacgtacg acatccaccg gctggagaag atcctgaagg cccgagagca tgtccgcatg   2760

gtcatcatta accagctcca accctttgca gaaatctgca atgatgccaa ggtgccagcc   2820

aaagacagca gcattcccaa gcgcaagaga aagcgggtct cggaaggaaa ttccgtctcc   2880

tcttcctcct cgtcttcctc ttcctcgtcc tctaacccgg attcagtggc atcggccaac   2940

cagatctcac tcgtgcaatg gccaatgtac atggtggact atgccggcct gaacgtgcag   3000

ctcccgggac ctcttaatta ctagacctca gtactgaatc aggacctcac tcagaaagac   3060

taaaggaaat gtaatttatg tacaaaatgt atattcggat atgtatcgat gccttttagt   3120

ttttccaatg atttttacac tatattcctg ccaccaaggc ctttttaaat aagtaaaaaa   3180

agaaaaaaaa aaaaag                                                   3196


<210>  4001
<211>  944
<212>  PRT
<213>  Homo sapiens

<400>  4001

Met Ala Leu Leu Gly Lys Arg Cys Asp Val Pro Thr Asn Gly Cys Gly 
1               5                   10                  15


Pro Asp Arg Trp Asn Ser Ala Phe Thr Arg Lys Asp Glu Ile Ile Thr 
            20                  25                  30


Ser Leu Val Ser Ala Leu Asp Ser Met Cys Ser Ala Leu Ser Lys Leu 
        35                  40                  45


Asn Ala Glu Val Ala Cys Val Ala Val His Asp Glu Ser Ala Phe Val 
    50                  55                  60


Val Gly Thr Glu Lys Gly Arg Met Phe Leu Asn Ala Arg Lys Glu Leu 
65                  70                  75                  80


Gln Ser Asp Phe Leu Arg Phe Cys Arg Gly Pro Pro Trp Lys Asp Pro 
                85                  90                  95


Glu Ala Glu His Pro Lys Lys Val Gln Arg Gly Glu Gly Gly Gly Arg 
            100                 105                 110


Ser Leu Pro Arg Ser Ser Leu Glu His Gly Ser Asp Val Tyr Leu Leu 
        115                 120                 125


Arg Lys Met Val Glu Glu Val Phe Asp Val Leu Tyr Ser Glu Ala Leu 
    130                 135                 140


Gly Arg Ala Ser Val Val Pro Leu Pro Tyr Glu Arg Leu Leu Arg Glu 
145                 150                 155                 160


Pro Gly Leu Leu Ala Val Gln Gly Leu Pro Glu Gly Leu Ala Phe Arg 
                165                 170                 175


Arg Pro Ala Glu Tyr Asp Pro Lys Ala Leu Met Ala Ile Leu Glu His 
            180                 185                 190


Ser His Arg Ile Arg Phe Lys Leu Lys Arg Pro Leu Glu Asp Gly Gly 
        195                 200                 205


Arg Asp Ser Lys Ala Leu Val Glu Leu Asn Gly Val Ser Leu Ile Pro 
    210                 215                 220


Lys Gly Ser Arg Asp Cys Gly Leu His Gly Gln Ala Pro Lys Val Pro 
225                 230                 235                 240


Pro Gln Asp Leu Pro Pro Thr Ala Thr Ser Ser Ser Met Ala Ser Phe 
                245                 250                 255


Leu Tyr Ser Thr Ala Leu Pro Asn His Ala Ile Arg Glu Leu Lys Gln 
            260                 265                 270


Glu Ala Pro Ser Cys Pro Leu Ala Pro Ser Asp Leu Gly Leu Ser Arg 
        275                 280                 285


Pro Met Pro Glu Pro Lys Ala Thr Gly Ala Gln Asp Phe Ser Asp Cys 
    290                 295                 300


Cys Gly Gln Lys Pro Thr Gly Pro Gly Gly Pro Leu Ile Gln Asn Val 
305                 310                 315                 320


His Ala Ser Lys Arg Ile Leu Phe Ser Ile Val His Asp Lys Ser Glu 
                325                 330                 335


Lys Trp Asp Ala Phe Ile Lys Glu Thr Glu Asp Ile Asn Thr Leu Arg 
            340                 345                 350


Glu Cys Val Gln Ile Leu Phe Asn Ser Arg Tyr Ala Glu Ala Leu Gly 
        355                 360                 365


Leu Asp His Met Val Pro Val Pro Tyr Arg Lys Ile Ala Cys Asp Pro 
    370                 375                 380


Glu Ala Val Glu Ile Val Gly Ile Pro Asp Lys Ile Pro Phe Lys Arg 
385                 390                 395                 400


Pro Cys Thr Tyr Gly Val Pro Lys Leu Lys Arg Ile Leu Glu Glu Arg 
                405                 410                 415


His Ser Ile His Phe Ile Ile Lys Arg Met Phe Asp Glu Arg Ile Phe 
            420                 425                 430


Thr Gly Asn Lys Phe Thr Lys Asp Thr Thr Lys Leu Glu Pro Ala Ser 
        435                 440                 445


Pro Pro Glu Asp Thr Ser Ala Glu Val Ser Arg Ala Thr Val Leu Asp 
    450                 455                 460


Leu Ala Gly Asn Ala Arg Ser Asp Lys Gly Ser Met Ser Glu Asp Cys 
465                 470                 475                 480


Gly Pro Gly Thr Ser Gly Glu Leu Gly Gly Leu Arg Pro Ile Lys Ile 
                485                 490                 495


Glu Pro Glu Asp Leu Asp Ile Ile Gln Val Thr Val Pro Asp Pro Ser 
            500                 505                 510


Pro Thr Ser Glu Glu Met Thr Asp Ser Met Pro Gly His Leu Pro Ser 
        515                 520                 525


Glu Asp Ser Gly Tyr Gly Met Glu Met Leu Thr Asp Lys Gly Leu Ser 
    530                 535                 540


Glu Asp Ala Arg Pro Glu Glu Arg Pro Val Glu Asp Ser His Gly Asp 
545                 550                 555                 560


Val Ile Arg Pro Leu Arg Lys Gln Val Glu Leu Leu Phe Asn Thr Arg 
                565                 570                 575


Tyr Ala Lys Ala Ile Gly Ile Ser Glu Pro Val Lys Val Pro Tyr Ser 
            580                 585                 590


Lys Phe Leu Met His Pro Glu Glu Leu Phe Val Val Gly Leu Pro Glu 
        595                 600                 605


Gly Ile Ser Leu Arg Arg Pro Asn Cys Phe Gly Ile Ala Lys Leu Arg 
    610                 615                 620


Lys Ile Leu Glu Ala Ser Asn Ser Ile Gln Phe Val Ile Lys Arg Pro 
625                 630                 635                 640


Glu Leu Leu Thr Glu Gly Val Lys Glu Pro Ile Met Asp Ser Gln Glu 
                645                 650                 655


Arg Asp Ser Gly Asp Pro Leu Val Asp Glu Ser Leu Lys Arg Gln Gly 
            660                 665                 670


Phe Gln Glu Asn Tyr Asp Ala Arg Leu Ser Arg Ile Asp Ile Ala Asn 
        675                 680                 685


Thr Leu Arg Glu Gln Val Gln Asp Leu Phe Asn Lys Lys Tyr Gly Glu 
    690                 695                 700


Ala Leu Gly Ile Lys Tyr Pro Val Gln Val Pro Tyr Lys Arg Ile Lys 
705                 710                 715                 720


Ser Asn Pro Gly Ser Val Ile Ile Glu Gly Leu Pro Pro Gly Ile Pro 
                725                 730                 735


Phe Arg Lys Pro Cys Thr Phe Gly Ser Gln Asn Leu Glu Arg Ile Leu 
            740                 745                 750


Ala Val Ala Asp Lys Ile Lys Phe Thr Val Thr Arg Pro Phe Gln Gly 
        755                 760                 765


Leu Ile Pro Lys Pro Asp Glu Asp Asp Ala Asn Arg Leu Gly Glu Lys 
    770                 775                 780


Val Ile Leu Arg Glu Gln Val Lys Glu Leu Phe Asn Glu Lys Tyr Gly 
785                 790                 795                 800


Glu Ala Leu Gly Leu Asn Arg Pro Val Leu Val Pro Tyr Lys Leu Ile 
                805                 810                 815


Arg Asp Ser Pro Asp Ala Val Glu Val Thr Gly Leu Pro Asp Asp Ile 
            820                 825                 830


Pro Phe Arg Asn Pro Asn Thr Tyr Asp Ile His Arg Leu Glu Lys Ile 
        835                 840                 845


Leu Lys Ala Arg Glu His Val Arg Met Val Ile Ile Asn Gln Leu Gln 
    850                 855                 860


Pro Phe Ala Glu Ile Cys Asn Asp Ala Lys Val Pro Ala Lys Asp Ser 
865                 870                 875                 880


Ser Ile Pro Lys Arg Lys Arg Lys Arg Val Ser Glu Gly Asn Ser Val 
                885                 890                 895


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Asn Pro Asp Ser 
            900                 905                 910


Val Ala Ser Ala Asn Gln Ile Ser Leu Val Gln Trp Pro Met Tyr Met 
        915                 920                 925


Val Asp Tyr Ala Gly Leu Asn Val Gln Leu Pro Gly Pro Leu Asn Tyr 
    930                 935                 940


<210>  4002
<211>  681
<212>  DNA
<213>  Homo sapiens

<400>  4002
gaggggctgg gctgtgggcc atccccagct ccttgtctcg gtcatccggg cttgtaggac     60

cccctgtccc gagccacagc ccaggtgggt gcacttgggg agcatggaga gagacagcca    120

ctccctgcaa agggcctcag atggagggag aggcaggttc cacgtgcctg gagcaagaat    180

gcagcaggag aagcggggga agatgagacc caggcccacg tctgctagga gcacctcgga    240

ggaggaattc ccacctgaag accccaccac aaggatgtcg caaagctgaa acctgagctc    300

gggtcatacc aactaaatcc gggttcccat caccccacaa cgcagccttc aagccccttc    360

ccccgtggaa tgatgacaca gcggtgggct cggctctgca ctgcccaacc ctgcccggca    420

gtgaacaggc gagaccaccc agctgggacc cagggaagag gcaaagagga gacccctcag    480

cagggtccgt ttctcctgcc tgggcttgtc ctgcacccag gaccaatgtg gccctacagg    540

acagctagaa ccctcccctc ctcttctccc caagtgtccc cagagcttca gaaaagtgtg    600

tgcttaaagg acgattcaat gaaataattt tctaaaaaga gaataaatac atacatacat    660

aaagaagcag gagtgtacca g                                              681


<210>  4003
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  4003

Met Glu Arg Asp Ser His Ser Leu Gln Arg Ala Ser Asp Gly Gly Arg 
1               5                   10                  15


Gly Arg Phe His Val Pro Gly Ala Arg Met Gln Gln Glu Lys Arg Gly 
            20                  25                  30


Lys Met Arg Pro Arg Pro Thr Ser Ala Arg Ser Thr Ser Glu Glu Glu 
        35                  40                  45


Phe Pro Pro Glu Asp Pro Thr Thr Arg Met Ser Gln Ser 
    50                  55                  60


<210>  4004
<211>  5868
<212>  DNA
<213>  Homo sapiens

<400>  4004
aacatttagc agcaaactca acatacattt tggccaaacg cccaccggcc agttgtttaa     60

atcaatattt atccacagcc aaaaagcaga ggagagccag aactgaggcc agagccgagc    120

tctgatgcat ctctcatttc tcgggatgtt tctgtccctg tggttggaca cctctggcct    180

tgtgaagtgt gatgcactgt cacatctcct gttctgtgtc attggccaat gatcatatat    240

catgacctgc tggaaggcct gtctgtggct gggaccacac gccttgggcc ttatgcacac    300

tgggcactgg tcgggatcct ggggtgcaac agtggcaggc agacctggtt tctgccctca    360

aagagcttac agatggcagg ggcacccatg gcggcagaag acaccccagg cctggtgccc    420

tttgtggtgc cagccccatg gtcctcctgc ctgggccttc cctaccccat tgggtgcaga    480

aactccctgt ctgcaggtag gagacagagg gtaggttttc aggctccctt gggaactgca    540

gccctgctct ctgccatcaa cacccagcag gggccacaca gagagcaccg ggactgagcc    600

catagagggg aaccgagagg cccctgcctc tagtctctgc cttctttgct tggattggtg    660

cagggacagc tgccttgagg gcaggccctg gcactggggc agcctgtggg tgccccctgg    720

gtcaagaagg agaggggcag ggtagaacca ggagccaaag gaggctgatc tttgcatctc    780

atgggtgccc agctggacac tgtcataccc aggaagcctg tgccatgcca tggggaccca    840

caactggggg ccctggactt gagggggagg atgcagctct gtcccccagg aaccccattg    900

caacaggaca cagtcctgcc ctggggagcc cctgacctga gacaaagcag cctcggccct    960

gctgtatctt tccatacccc tgatgccaag tctcctggct aggagggaaa ctgaggctgg   1020

aaggcctcgg cgggggtggc attggcctcg ggagcatgtg gcttgatgca gaaatgtgac   1080

ggcagagctc agaggcatgc ggaagggagg ggaggacatc accggctcct gacccagctg   1140

ggcttcaggt tgggggtaca ggaggtgggc aagcaggttg gacaattaaa agcttcgatg   1200

aggctgggtg agtggcttat gcctgtattt ccaacacttt gggaggctga ggtgggcaga   1260

tcacctgagg ccaggagttc aagaccagcc tggccaacat ggtgaaaccc catctctact   1320

aaaaatacaa aaattagcca gacgtgtggt ggcacctgta atcccagcta cccgggaggc   1380

tgaggcagga gaatcactcg aacccaggaa ggggaggttg cagtgagcca agattgcacc   1440

actgcactat agcctgggca acagagtgag actctgtctc gaaataaaat taaatttaaa   1500

atttaaaaaa gcttcaagga caaccagcag atgatggcag gaccaggaag ggtgcttcag   1560

gcagcgggaa ctgaacctgc acagactagg gaagcatgaa catcggtaca tctgggagtg   1620

gcacagctta gagggcctgg agcatggagt gtgaggggga actggagtga gggacaggag   1680

accaggcgac catggccttg ctgggtaagc gctgtgacgt ccccaccaac ggctgcggac   1740

ccgaccgctg gaactccgcg ttcacccgca aagacgagat catcaccagc ctcgtgtctg   1800

ccttagactc catgtgctca gcgctgtcca aactgaacgc cgaggtggcc tgtgtcgccg   1860

tgcacgatga gagcgccttt gtggtgggca cagagaaggg gagaatgttc ctgaatgccc   1920

ggaaggagct acagtcagac ttcctcaggt tctgccgagg gcccccgtgg aaggatccgg   1980

aggcagagca ccccaagaag gtgcagcggg gcgagggtgg aggccgtagc ctccctcggt   2040

cctccctgga acatggctca gatgtgtacc ttctgcggaa gatggtagag gaggtgtttg   2100

atgttcttta tagcgaggcc ctgggaaggg ccagtgtggt gccactgccc tatgagaggc   2160

tgctcaggga gccagggctg ctggccgtgc aggggctgcc cgaaggcctg gccttccgaa   2220

ggccagccga gtatgacccc aaggccctca tggccatcct ggaacacagc caccgcatcc   2280

gcttcaagct caagaggcca cttgaggatg gcgggcggga ctcgaaggcc ctggtggagc   2340

tgaacggtgt ctccctgatt cccaaggggt cacgggactg tggcctgcat ggccaggccc   2400

ccaaggtgcc accccaggac ctgcccccaa ccgccacctc ctcctccatg gccagcttcc   2460

tgtacagcac ggcgctcccc aaccacgcca tccgagagct caagcaggaa gcaccttcct   2520

gcccccttgc ccccagcgac ctgggcctga gtcggcccat gccagagccc aaggccaccg   2580

gtgcccaaga cttctccgac tgttgtggac agaagcccac tgggcctggt gggcctctca   2640

tccagaacgt ccatgcctcc aagcgcattc tcttctccat cgtccatgac aagtcagaga   2700

agtgggacgc cttcataaag gaaaccgagg acatcaacac gctccgggag tgtgtgcaga   2760

tcctgtttaa cagcagatat gcggaagccc tgggcctgga ccacatggtc cccgtgccct   2820

accggaagat tgcctgtgac ccggaggctg tggagatcgt gggcatcccg gacaagatcc   2880

ccttcaagcg cccctgcact tatggagtcc ccaagctgaa gcggatcctg gaggagcgcc   2940

atagtatcca cttcatcatt aagaggatgt ttgatgagcg aattttcaca gggaacaagt   3000

ttaccaaaga caccacgaag ctggagccag ccagcccgcc agaggacacc tctgcagagg   3060

tctctagggc caccgtcctt gaccttgctg ggaatgctcg gtcagacaag ggcagcatgt   3120

ctgaagactg tgggccagga acctccgggg agctgggcgg gctgaggccg atcaaaattg   3180

agccagagga tctggacatc attcaggtca ccgtcccaga cccctcgcca acctctgagg   3240

aaatgacaga ctcgatgcct gggcacctgc catcggagga ttctggttat gggatggaga   3300

tgctgacaga caaaggtctg agtgaggacg cgcggcccga ggagaggccc gtggaggaca   3360

gccacggtga cgtgatccgg cccctgcgga agcaggtgga gctgctcttc aacacacgat   3420

acgccaaggc cattggcatc tcggagcccg tcaaggtgcc gtactccaag tttctgatgc   3480

acccggagga gctgtttgtg gtgggactgc ctgaaggcat ctccctccgc aggcccaact   3540

gcttcgggat cgccaagctc cggaagattc tggaggccag caacagcatc cagtttgtca   3600

tcaagaggcc cgagctgctc actgagggag tcaaagagcc catcatggat agtcaagaga   3660

gggattccgg ggaccctctg gtggacgaga gcctgaagag acagggcttt caagaaaatt   3720

atgacgcgag gctctcacgg atcgacatcg ccaacacact aagggagcag gtccaggacc   3780

ttttcaataa gaaatacggg gaagccttgg gcatcaagta cccggtccag gtcccctaca   3840

agcggatcaa gagtaacccc ggctccgtga tcatcgaggg gctgccccca ggaatcccgt   3900

tccgaaagcc ctgtaccttc ggctcccaga acctggagag gattcttgct gtggctgaca   3960

agatcaagtt cacagtcacc aggcctttcc aaggactcat cccaaagcct gatgaagatg   4020

acgccaacag actcggggag aaggtgatcc tgcgggagca ggtgaaggaa ctcttcaacg   4080

agaaatacgg tgaggccctg ggcctgaacc ggccggtgct ggtcccttat aaactaatcc   4140

gggacagccc agacgccgtg gaggtcacgg gtctgcctga tgacatcccc ttccggaacc   4200

ccaacacgta cgacatccac cggctggaga agatcctgaa ggcccgagag catgtccgca   4260

tggtcatcat taaccagctc caaccctttg cagaaatctg caatgatgcc aaggtgccag   4320

ccaaagacag cagcattccc aagcgcaaga gaaagcgggt ctcggaagga aattccgtct   4380

cctcttcctc ctcgtcttcc tcttcctcgt cctctaaccc ggattcagtg gcatcggcca   4440

accagatctc actcgtggta aagttgcacc gatttggact ccggcactca tctctgtggc   4500

cctcacccct ctgtctggca gggccgtcta ctctgggatg tgggcccagg ggacggggag   4560

gcactgggct ttgagtgggg accttccggc ctcgggggtt atagatgcat ccacctgtct   4620

cacccaagag gtagcccatc cttctcgtgg ggtactcaca ggcactcagg caggaattca   4680

catcctcgct gggcagatgg gccggctgag gtccacctgc ccacaccctt cagccgcacc   4740

agagctggag acatgaaaag acatggctgg cgggtgcagt ggctcacgcc tgtaatccca   4800

gcactttggc aggtcaagtc gggtggatca cctgaggtca ggagtttgag accaggctga   4860

ccaacacggg gaaaccccat ctctactaaa aatacaaaat tagccgggca aagtggggca   4920

tagtggctca tgcctgtaat cccagctact tggaaggctg agataggaga atcgcttgaa   4980

cctgggaggc agaggttgca atgagccgag gtcgcgccat tgcactgcag cctgggcaac   5040

aagagtgaaa cactgtctca gaaaaaaaaa ttagccaggc atggtggcac gtgcctgtgg   5100

tcgcagctac ttgggaggct ggggcaggag gatcatttga gcccaagggg attgaggctg   5160

cagtgagcca agatcgtccc attgcactcc agcctgggca agagaacgag actccatctc   5220

aaaaataaat aaataggctg ggtgtggtgg ctcacgcctg taatcctagc actttgggag   5280

gccgaggcag gcggatcact tgaggctcag gagttcaaga ccagcctggc caacatggca   5340

aaaccccgtc tctactaaaa atagaaaaat tagccgggca tggtggcggg cgcctataat   5400

cccagctact cgggaggctg aggcaggaga ctcgcttgaa cccgcggggc caaggttgca   5460

gtgagccgag attgcatcac tgcactccag cctgggcaga agagtgaaac tccatctcaa   5520

aaaaataaaa aatataaata aatagcctct gagaaagctc ttccaaaagc agaactaagc   5580

attttgggtt tgttccgcat cacctggagt cctaatccag tccctttgtc cctctctcta   5640

gcaatggcca atgtacatgg tggactatgc cggcctgaac gtgcagctcc cgggacctct   5700

taattactag acctcagtac tgaatcagga cctcactcag aaagactaaa ggaaatgtaa   5760

tttatgtaca aaatgtatat tcggatatgt atcgatgcct tttagttttt ccaatgattt   5820

ttacactata ttcctgccac caaggccttt ttaaataagt aaaaaaag                5868


<210>  4005
<211>  960
<212>  PRT
<213>  Homo sapiens

<400>  4005

Met Ala Leu Leu Gly Lys Arg Cys Asp Val Pro Thr Asn Gly Cys Gly 
1               5                   10                  15


Pro Asp Arg Trp Asn Ser Ala Phe Thr Arg Lys Asp Glu Ile Ile Thr 
            20                  25                  30


Ser Leu Val Ser Ala Leu Asp Ser Met Cys Ser Ala Leu Ser Lys Leu 
        35                  40                  45


Asn Ala Glu Val Ala Cys Val Ala Val His Asp Glu Ser Ala Phe Val 
    50                  55                  60


Val Gly Thr Glu Lys Gly Arg Met Phe Leu Asn Ala Arg Lys Glu Leu 
65                  70                  75                  80


Gln Ser Asp Phe Leu Arg Phe Cys Arg Gly Pro Pro Trp Lys Asp Pro 
                85                  90                  95


Glu Ala Glu His Pro Lys Lys Val Gln Arg Gly Glu Gly Gly Gly Arg 
            100                 105                 110


Ser Leu Pro Arg Ser Ser Leu Glu His Gly Ser Asp Val Tyr Leu Leu 
        115                 120                 125


Arg Lys Met Val Glu Glu Val Phe Asp Val Leu Tyr Ser Glu Ala Leu 
    130                 135                 140


Gly Arg Ala Ser Val Val Pro Leu Pro Tyr Glu Arg Leu Leu Arg Glu 
145                 150                 155                 160


Pro Gly Leu Leu Ala Val Gln Gly Leu Pro Glu Gly Leu Ala Phe Arg 
                165                 170                 175


Arg Pro Ala Glu Tyr Asp Pro Lys Ala Leu Met Ala Ile Leu Glu His 
            180                 185                 190


Ser His Arg Ile Arg Phe Lys Leu Lys Arg Pro Leu Glu Asp Gly Gly 
        195                 200                 205


Arg Asp Ser Lys Ala Leu Val Glu Leu Asn Gly Val Ser Leu Ile Pro 
    210                 215                 220


Lys Gly Ser Arg Asp Cys Gly Leu His Gly Gln Ala Pro Lys Val Pro 
225                 230                 235                 240


Pro Gln Asp Leu Pro Pro Thr Ala Thr Ser Ser Ser Met Ala Ser Phe 
                245                 250                 255


Leu Tyr Ser Thr Ala Leu Pro Asn His Ala Ile Arg Glu Leu Lys Gln 
            260                 265                 270


Glu Ala Pro Ser Cys Pro Leu Ala Pro Ser Asp Leu Gly Leu Ser Arg 
        275                 280                 285


Pro Met Pro Glu Pro Lys Ala Thr Gly Ala Gln Asp Phe Ser Asp Cys 
    290                 295                 300


Cys Gly Gln Lys Pro Thr Gly Pro Gly Gly Pro Leu Ile Gln Asn Val 
305                 310                 315                 320


His Ala Ser Lys Arg Ile Leu Phe Ser Ile Val His Asp Lys Ser Glu 
                325                 330                 335


Lys Trp Asp Ala Phe Ile Lys Glu Thr Glu Asp Ile Asn Thr Leu Arg 
            340                 345                 350


Glu Cys Val Gln Ile Leu Phe Asn Ser Arg Tyr Ala Glu Ala Leu Gly 
        355                 360                 365


Leu Asp His Met Val Pro Val Pro Tyr Arg Lys Ile Ala Cys Asp Pro 
    370                 375                 380


Glu Ala Val Glu Ile Val Gly Ile Pro Asp Lys Ile Pro Phe Lys Arg 
385                 390                 395                 400


Pro Cys Thr Tyr Gly Val Pro Lys Leu Lys Arg Ile Leu Glu Glu Arg 
                405                 410                 415


His Ser Ile His Phe Ile Ile Lys Arg Met Phe Asp Glu Arg Ile Phe 
            420                 425                 430


Thr Gly Asn Lys Phe Thr Lys Asp Thr Thr Lys Leu Glu Pro Ala Ser 
        435                 440                 445


Pro Pro Glu Asp Thr Ser Ala Glu Val Ser Arg Ala Thr Val Leu Asp 
    450                 455                 460


Leu Ala Gly Asn Ala Arg Ser Asp Lys Gly Ser Met Ser Glu Asp Cys 
465                 470                 475                 480


Gly Pro Gly Thr Ser Gly Glu Leu Gly Gly Leu Arg Pro Ile Lys Ile 
                485                 490                 495


Glu Pro Glu Asp Leu Asp Ile Ile Gln Val Thr Val Pro Asp Pro Ser 
            500                 505                 510


Pro Thr Ser Glu Glu Met Thr Asp Ser Met Pro Gly His Leu Pro Ser 
        515                 520                 525


Glu Asp Ser Gly Tyr Gly Met Glu Met Leu Thr Asp Lys Gly Leu Ser 
    530                 535                 540


Glu Asp Ala Arg Pro Glu Glu Arg Pro Val Glu Asp Ser His Gly Asp 
545                 550                 555                 560


Val Ile Arg Pro Leu Arg Lys Gln Val Glu Leu Leu Phe Asn Thr Arg 
                565                 570                 575


Tyr Ala Lys Ala Ile Gly Ile Ser Glu Pro Val Lys Val Pro Tyr Ser 
            580                 585                 590


Lys Phe Leu Met His Pro Glu Glu Leu Phe Val Val Gly Leu Pro Glu 
        595                 600                 605


Gly Ile Ser Leu Arg Arg Pro Asn Cys Phe Gly Ile Ala Lys Leu Arg 
    610                 615                 620


Lys Ile Leu Glu Ala Ser Asn Ser Ile Gln Phe Val Ile Lys Arg Pro 
625                 630                 635                 640


Glu Leu Leu Thr Glu Gly Val Lys Glu Pro Ile Met Asp Ser Gln Glu 
                645                 650                 655


Arg Asp Ser Gly Asp Pro Leu Val Asp Glu Ser Leu Lys Arg Gln Gly 
            660                 665                 670


Phe Gln Glu Asn Tyr Asp Ala Arg Leu Ser Arg Ile Asp Ile Ala Asn 
        675                 680                 685


Thr Leu Arg Glu Gln Val Gln Asp Leu Phe Asn Lys Lys Tyr Gly Glu 
    690                 695                 700


Ala Leu Gly Ile Lys Tyr Pro Val Gln Val Pro Tyr Lys Arg Ile Lys 
705                 710                 715                 720


Ser Asn Pro Gly Ser Val Ile Ile Glu Gly Leu Pro Pro Gly Ile Pro 
                725                 730                 735


Phe Arg Lys Pro Cys Thr Phe Gly Ser Gln Asn Leu Glu Arg Ile Leu 
            740                 745                 750


Ala Val Ala Asp Lys Ile Lys Phe Thr Val Thr Arg Pro Phe Gln Gly 
        755                 760                 765


Leu Ile Pro Lys Pro Asp Glu Asp Asp Ala Asn Arg Leu Gly Glu Lys 
    770                 775                 780


Val Ile Leu Arg Glu Gln Val Lys Glu Leu Phe Asn Glu Lys Tyr Gly 
785                 790                 795                 800


Glu Ala Leu Gly Leu Asn Arg Pro Val Leu Val Pro Tyr Lys Leu Ile 
                805                 810                 815


Arg Asp Ser Pro Asp Ala Val Glu Val Thr Gly Leu Pro Asp Asp Ile 
            820                 825                 830


Pro Phe Arg Asn Pro Asn Thr Tyr Asp Ile His Arg Leu Glu Lys Ile 
        835                 840                 845


Leu Lys Ala Arg Glu His Val Arg Met Val Ile Ile Asn Gln Leu Gln 
    850                 855                 860


Pro Phe Ala Glu Ile Cys Asn Asp Ala Lys Val Pro Ala Lys Asp Ser 
865                 870                 875                 880


Ser Ile Pro Lys Arg Lys Arg Lys Arg Val Ser Glu Gly Asn Ser Val 
                885                 890                 895


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Asn Pro Asp Ser 
            900                 905                 910


Val Ala Ser Ala Asn Gln Ile Ser Leu Val Val Lys Leu His Arg Phe 
        915                 920                 925


Gly Leu Arg His Ser Ser Leu Trp Pro Ser Pro Leu Cys Leu Ala Gly 
    930                 935                 940


Pro Ser Thr Leu Gly Cys Gly Pro Arg Gly Arg Gly Gly Thr Gly Leu 
945                 950                 955                 960


<210>  4006
<211>  2613
<212>  DNA
<213>  Homo sapiens

<400>  4006
cacttgtaat cctagcactt ggaaaggctg agacaggagg atcacttgag gccaggagtt     60

tgagaccaac ctgggcaata tagtgagacc ctatttctac aaaaaataaa ataaatagcc    120

aggcctggtg gtatgcacct gtagtcctag ctactgagga ggctgacgga ggaggatcac    180

ttgagcccag gaattggagg ctgcagtgag ctatgatcac gccactgcac tccagcctgg    240

gcgacagagc cagaccctat ctctgaaaac aataataaaa cgacaaccaa tgctgactgt    300

gtctccatca ctgggtgggg ctgaggaagc aggcctcaga aaggaagcca gttttccccc    360

aaaattattc cctgaggctg cctctgggcc tgtggatcca gatgtgtggg ggccttcagg    420

agtggcaggg gagtggggcc tccagcgtga aaacagaagt caccgtcagc cttgcacccc    480

cggctctgcc tcccaggact ggtgtttttg cctctgtttt aatttcctgc tgggtcctcc    540

cttggacatt gtcaggtatg caggctggga catcccttct ttcctcctac attcccccta    600

gagcccaagg ctctgtccgt ggtccagcca ctccatggca gggaagctgt acctccataa    660

tcagctgcct gagggcccct gacccaccac caggcaccac cctggtgggg ctgaggttag    720

aagggaaaga atgccagaac tccagtcctg gaggcaggag agtgtgtgag cccagccccg    780

ccctctcaga ctctcagacc tttatttcat cctcattttc ctggctagag gttccatgca    840

tcattttttt tttttttttt ttcagatgga gtctcactct attgcccagg ctggagtgca    900

gtggtgctat gtcggctcac tgaaacctcc gcctctcagg ttcaagcaat tctcctgcct    960

ccgcctccca agtagctggg attacaggca tgcaccacca cacctggcta gtttttgtat   1020

ttttagtaga gacggggttt caccatgttg gccaggctgg tctcaaactc ctgacctcag   1080

gtgatccacc tgcctgggct tcccaaagta ctgggattat aggcttgagc caccacgccc   1140

ggctggttcc atgcatctta cctggatgac ttgggtccct aaatgggccc ctgggtgccc   1200

agcctcccct cctccaatac attctctgat aatctgacct tgtcatgacc attggggcac   1260

ctgttgccca cagggtagag gccaggtgcc tgaggacagc actgaaggcc gtgcacctcc   1320

acctccagcc tccagtcacc tcacctagct cactgctctc tctcctgcaa agtctctcct   1380

gcttccctcc ctaagggaag ggctggccgc tcactgcttg ggcccccttg atttctaaga   1440

cacctgtgaa gggtcccaca aggccaggca cagtggctct tgtctgtaat cccagcgctc   1500

tgggaggctg aggcaggagg atcacttgag gtcaggagtt caatgtggac aacacagtaa   1560

gaccctgtct ctacaaaaaa atttaaaact tagctggcat tggtggcgca tgcctatagt   1620

cccagctact tgggaggttg aggtaggagg atcgcttgaa cccaggagtt caagtctgca   1680

gtgagctatg attgcaccac tgcactccag cctgggtgat agagcaagac cccaactcaa   1740

aaaaaaaaaa aaggatccca cggttcacct tgtgctgcca cgatcggttg gcagctctgc   1800

tctgtgccgt cctgtgcctg tcactgagta agatgcagga gaagttgggc aaaagccctc   1860

aggataaacg aataagtcat tcagagtagg tgctggtggg aaatgggctt gagtcactca   1920

cctggggcca gaagaggccc ccagggagtt gtgagcagat tagaccctcc aagaccgccc   1980

caggggttgg cccatgcttt ccctaactgt gcaaaaatgg tttgggatag gctgggtgcc   2040

gtgggtcacg cctgtaatcc cagcactttg ggaggctgag gcaggtggat cacctcaagt   2100

caggagttcg agaccagcct ggccaacatg gtgaaacccc atctctacta aaaatacaga   2160

aattagctgg gtgtggttgc acacgcctgt aatcccagct actcaggagg ctgagggagg   2220

agaatccctt gaacccggga ggcggaggtt catggggaac ccagcaggaa attagaatag   2280

aaccaaaaac gccagtcatg ggaggcagag ctgggggagc gaggctgaca atgactcctg   2340

ttttcacgct gagagacccc actcccctgc tgagatcgcg ccactgcact ccagcctggg   2400

cgacagagca agactccatc tcaaaaaaaa agttaattaa ttaattagat taaagtacaa   2460

caattagcag ggcatggtgg tgcacgtctg tagtcccagc tactcaggag gctgaggcag   2520

aagaatcgct tgaaccctgg aggcggaggt tgccgtgagc caagatcgca ccactgcact   2580

ccagcctggg cgacaaagtg agactctgtc tcc                                2613


<210>  4007
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  4007

Met Cys Gly Gly Leu Gln Glu Trp Gln Gly Ser Gly Ala Ser Ser Val 
1               5                   10                  15


Lys Thr Glu Val Thr Val Ser Leu Ala Pro Pro Ala Leu Pro Pro Arg 
            20                  25                  30


Thr Gly Val Phe Ala Ser Val Leu Ile Ser Cys Trp Val Leu Pro Trp 
        35                  40                  45


Thr Leu Ser Gly Met Gln Ala Gly Thr Ser Leu Leu Ser Ser Tyr Ile 
    50                  55                  60


Pro Pro Arg Ala Gln Gly Ser Val Arg Gly Pro Ala Thr Pro Trp Gln 
65                  70                  75                  80


Gly Ser Cys Thr Ser Ile Ile Ser Cys Leu Arg Ala Pro Asp Pro Pro 
                85                  90                  95


Pro Gly Thr Thr Leu Val Gly Leu Arg Leu Glu Gly Lys Glu Cys Gln 
            100                 105                 110


Asn Ser Ser Pro Gly Gly Arg Arg Val Cys Glu Pro Ser Pro Ala Leu 
        115                 120                 125


Ser Asp Ser Gln Thr Phe Ile Ser Ser Ser Phe Ser Trp Leu Glu Val 
    130                 135                 140


Pro Cys Ile Ile Phe Phe Phe Phe Phe Phe Arg Trp Ser Leu Thr Leu 
145                 150                 155                 160


Leu Pro Arg Leu Glu Cys Ser Gly Ala Met Ser Ala His 
                165                 170


<210>  4008
<211>  496
<212>  DNA
<213>  Homo sapiens

<400>  4008
gtgtcattcg gagttttgtc ttcagacccc tcgccaacct ctgaggaaat gacagactcg     60

atgcctgggc acctgccatc ggaggattct ggttatggga tggagatgct gacaggtaag    120

aaatggacct gggctggtgg tgcttgggac tcagctctcc agggagcaaa gggaaagggg    180

tgggccaggc cgtccccagg tgtttcttgg tgtcagccgt ctgtagtaga ggaaacccaa    240

tatatgcctg accctaatcc aaggctgggt tccttttgga aacctcaagt aggctctatt    300

tatttattta gagacggagt ttcactcttg ttgcccaggc tggagttgca gtgagccaag    360

attttgccat tgcactccag cctggacaac agagcgaagc tctgcctcaa aataactaaa    420

tagatagata gatagataga tagatagata aaaattagac aggaacggta ggacctatgt    480

gtagtcccat ctactc                                                    496


<210>  4009
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  4009

Met Thr Asp Ser Met Pro Gly His Leu Pro Ser Glu Asp Ser Gly Tyr 
1               5                   10                  15


Gly Met Glu Met Leu Thr Gly Lys Lys Trp Thr Trp Ala Gly Gly Ala 
            20                  25                  30


Trp Asp Ser Ala Leu Gln Gly Ala Lys Gly Lys Gly Trp Ala Arg Pro 
        35                  40                  45


Ser Pro Gly Val Ser Trp Cys Gln Pro Ser Val Val Glu Glu Thr Gln 
    50                  55                  60


Tyr Met Pro Asp Pro Asn Pro Arg Leu Gly Ser Phe Trp Lys Pro Gln 
65                  70                  75                  80


Val Gly Ser Ile Tyr Leu Phe Arg Asp Gly Val Ser Leu Leu Leu Pro 
                85                  90                  95


Arg Leu Glu Leu Gln 
            100


<210>  4010
<211>  448
<212>  DNA
<213>  Homo sapiens

<400>  4010
cagagcactt ttccagggag ctcaggaggc tgagacagaa aagcctcagc ttccagtgtc     60

aacagccttt tcccctcctt ccagccaaag acagcagcat tcccaagcgc aagagaaagc    120

gggtctcgga aggaaattcc gtctcctctt cctcctcgtc ttcctcttcc tcgtcctcta    180

acccggattc agtggcatcg gccaaccaga tctcactcgt gcaatggcca atgtacatgg    240

tggactatgc cggcctgaac gtgcagctcc cgggacctct taattactag acctcagtac    300

tgaatcagga cctcactcag aaagactaaa ggaaatgtaa tttatgtaca aaatgtatat    360

tcggatatgt atcgatgcct tttagttttt ccaatgattt ttacactata ttcctgccac    420

caaggccttt ttaaataagt aaaaaaag                                       448


<210>  4011
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  4011

Arg Ala Leu Phe Gln Gly Ala Gln Glu Ala Glu Thr Glu Lys Pro Gln 
1               5                   10                  15


Leu Pro Val Ser Thr Ala Phe Ser Pro Pro Ser Ser Gln Arg Gln Gln 
            20                  25                  30


His Ser Gln Ala Gln Glu Lys Ala Gly Leu Gly Arg Lys Phe Arg Leu 
        35                  40                  45


Leu Phe Leu Leu Val Phe Leu Phe Leu Val Leu 
    50                  55


<210>  4012
<211>  272
<212>  DNA
<213>  Homo sapiens

<400>  4012
cagccacgcc ttccagccca gagcaaagtt ttcagaagat aagaactctg tggttttcag     60

caaggagaca ataagaagtt gttcctaatt ggcttcctgt cgcagtcctc agggcacctg    120

ctggttccag cctggatcca gcctaccttg acctttgcca gttggcaccg atgtgcagat    180

aaccagtgaa gcccaggagc aaatcctcaa atccagacct gtttcagctc catgctgtgc    240

cgtgagaaac ctctctgcag gtccctactt ga                                  272


<210>  4013
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  4013

Pro Leu Pro Val Gly Thr Asp Val Gln Ile Thr Ser Glu Ala Gln Glu 
1               5                   10                  15


Gln Ile Leu Lys Ser Arg Pro Val Ser Ala Pro Cys Cys Ala Val Arg 
            20                  25                  30


Asn Leu Ser Ala Gly Pro Tyr 
        35


<210>  4014
<211>  1356
<212>  DNA
<213>  Homo sapiens

<400>  4014
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa ggttaggaga aaaagagatt   1260

gcatattttc cactatttgt tgtatgttta ttctatttta tagattctat tatccttaaa   1320

acaccttatt tggaaataaa aggtgattcc cttggt                             1356


<210>  4015
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  4015

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Gly 



<210>  4016
<211>  4207
<212>  DNA
<213>  Homo sapiens

<400>  4016
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   2040

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2100

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2160

tgaaaggatc gtccgcggga gtaataaaat caagttcgtt gttaaaaaac ctgaactagt   2220

tatttcctac ttgcctcctg ggatggctag taaaataaac actaaagctt tgcagtcccc   2280

caaaagacca cgaagtcctg ggagtaattc aaaggttcct gaaattgagg tcaccgtgga   2340

aggccctaat aacaacaatc ctcaaacctc agctgttcga accccgaccc agactaacgg   2400

ttctaacgtt cccttcaagc cacgagggag agagttttcc tttgaggcct ggaatgccaa   2460

aatcacggac ctaaaacaga aagttgaaaa tctcttcaat gagaaatgtg gggaagctct   2520

tggccttaaa caagctgtga aggtgccgtt cgcgttattt gagtctttcc cggaagactt   2580

ttatgtggaa ggcttacctg agggtgtgcc attccgaaga ccatcgactt ttggcattcc   2640

gaggctggag aagatactca gaaacaaagc caaaattaag ttcatcatta aaaagcccga   2700

aatgtttgag acggcgatta aggagagcac ctcctctaag agccctccca gaaaaataaa   2760

ttcatcaccc aatgttaata ctactgcatc aggtgttgaa gaccttaaca tcattcaggt   2820

gacaattcca gatgatgata atgaaagact ctcgaaagtt gaaaaagcta gacagctaag   2880

agaacaagtg aatgacctct ttagtcggaa atttggtgaa gctattggta tgggttttcc   2940

tgtgaaagtt ccctacagga aaatcacaat taaccctggc tgtgtggtgg ttgatggcat   3000

gcccccgggg gtgtccttca aagcccccag ctacctggaa atcagctcca tgagaaggat   3060

cttagactct gccgagttta tcaaattcac ggtcattaga ccatttccag gacttgtgat   3120

taataaccag ctggttgatc agagtgagtc agaaggcccc gtgatacaag aatcagctga   3180

accaagccag ttggaagttc cagccacaga agaaataaaa gagactgatg gaagctctca   3240

gatcaagcaa gaaccagacc ccacgtggta gacctcttcc ctcctaggct taaagtatca   3300

gtggttgaga agagcttttc ggacctgtta ctaccccaag ctgtagcctt gagttacggt   3360

gtttattttc caatcaagtg aagatatctc ctacttctcc tactggaaca tctcagcttc   3420

tgcagtgaag aaaaattcct gtgatagttc agttctttag tttttctatt tgaaaaaaaa   3480

aaatcattta aatgatcctt tgttcacggc tctccttaat gactgagtga acagttccta   3540

tctgtatatt tgactaaacc ttttcctaag ctatctctca tggttcctat gtttttttat   3600

cataattaaa agcaaaacca tctggatcac ctaacagtca gaggtcagta tctcagcgtg   3660

tgaattatag aggaaataca gagagaacct cttccacttt tacttttcgt ccaaataaaa   3720

tgcatggtgt accagaagtt gaagatcggg ttgaggattg gggctagctc gatgacacta   3780

aggccccaac atcgcgggac ctgctgtggc gcggattctt aggaacgctg ttctagccgg   3840

ccccctctcc aggggtcgcc gtggccggca ttatttccta gttcttcttg taaccctgag   3900

gtgccagcgc ggggagtgag gaggggtcag ggggctaagg atgcaacctc tgacgttctg   3960

cgccttccta ggagagtctt acatgtgttg agatttcaca agcaatgcga gttgtaaaat   4020

accagctcta caagaagcta ggctctgtga cggcatagtt ttcagtagct ttatcacaat   4080

attcacaatg gagaattata tgacatggta gcagaaatag gcccttttat gtgttgcttc   4140

tattttacct caaattgtag atatagggta atcaataaaa tccatccatg cctttcacac   4200

actaagt                                                             4207


<210>  4017
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  4017

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala 
            580                 585                 590


Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600                 605


<210>  4018
<211>  3791
<212>  DNA
<213>  Homo sapiens

<400>  4018
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agctcaagct cttggactca ccgaggcagt aaaagtacca tatcctgtgt   1980

ttgaatcaaa cccggagttc ttgtatgtgg aaggcttgcc agaggggatt cccttccgaa   2040

gccctacctg gtttggaatt ccacgacttg aaaggatcgt ccgcgggagt aataaaatca   2100

agttcgttgt taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta   2160

aaataaacac taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa   2220

aggttcctga aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag   2280

ctgttcgaac cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag   2340

agttttcctt tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc   2400

tcttcaatga gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg   2460

cgttatttga gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat   2520

tccgaagacc atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca   2580

aaattaagtt catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct   2640

cctctaagag ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag   2700

gtgttgaaga ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct   2760

cgaaagttga aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat   2820

ttggtgaagc tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta   2880

accctggctg tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct   2940

acctggaaat cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg   3000

tcattagacc atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag   3060

aaggccccgt gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag   3120

aaataaaaga gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga   3180

cctcttccct cctaggcaaa accatctgga tcacctaaca gtcagaggtc agtatctcag   3240

cgtgtgaatt atagaggaaa tacagagaga acctcttcca cttttacttt tcgtccaaat   3300

aaaatgcatg gtgtaccaga agttgaagat cgggttgagg attggggcta gctcgatgac   3360

actaaggccc caacatcgcg ggacctgctg tggcgcggat tcttaggaac gctgttctag   3420

ccggccccct ctccaggggt cgccgtggcc ggcattattt cctagttctt cttgtaaccc   3480

tgaggtgcca gcgcggggag tgaggagggg tcagggggct aaggatgcaa cctctgacgt   3540

tctgcgcctt cctaggagag tcttacatgt gttgagattt cacaagcaat gcgagttgta   3600

aaataccagc tctacaagaa gctaggctct gtgacggcat agttttcagt agctttatca   3660

caatattcac aatggagaat tatatgacat ggtagcagaa ataggccctt ttatgtgttg   3720

cttctatttt acctcaaatt gtagatatag ggtaatcaat aaaatccatc catgcctttc   3780

acacactaag t                                                        3791


<210>  4019
<211>  864
<212>  PRT
<213>  Homo sapiens

<400>  4019

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro 
    450                 455                 460


Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu 
465                 470                 475                 480


Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu 
                485                 490                 495


Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro 
            500                 505                 510


Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn 
        515                 520                 525


Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn 
    530                 535                 540


Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn 
545                 550                 555                 560


Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser 
                565                 570                 575


Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp 
            580                 585                 590


Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn 
        595                 600                 605


Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro 
    610                 615                 620


Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu 
625                 630                 635                 640


Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg 
                645                 650                 655


Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys 
            660                 665                 670


Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys 
        675                 680                 685


Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala 
    690                 695                 700


Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp 
705                 710                 715                 720


Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu 
                725                 730                 735


Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met 
            740                 745                 750


Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly 
        755                 760                 765


Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro 
    770                 775                 780


Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu 
785                 790                 795                 800


Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn 
                805                 810                 815


Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu 
            820                 825                 830


Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys 
        835                 840                 845


Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
    850                 855                 860


<210>  4020
<211>  5052
<212>  DNA
<213>  Homo sapiens

<400>  4020
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   2040

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2100

taccatatcc tgtgtttgaa tcaaacccgg agttcttgaa aggatcgtcc gcgggagtaa   2160

taaaatcaag ttcgttgtta aaaaacctga actagttatt tcctacttgc ctcctgggat   2220

ggctagtaaa ataaacacta aagctttgca gtcccccaaa agaccacgaa gtcctgggag   2280

taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc cctaataaca acaatcctca   2340

aacctcagct gttcgaaccc cgacccagac taacggttct aacgttccct tcaagccacg   2400

agggagagag ttttcctttg aggcctggaa tgccaaaatc acggacctaa aacagaaagt   2460

tgaaaatctc ttcaatgaga aatgtgggga agctcttggc cttaaacaag ctgtgaaggt   2520

gccgttcgcg ttatttgagt ctttcccgga agacttttat gtggaaggct tacctgaggg   2580

tgtgccattc cgaagaccat cgacttttgg cattccgagg ctggagaaga tactcagaaa   2640

caaagccaaa attaagttca tcattaaaaa gcccgaaatg tttgagacgg cgattaagga   2700

gagcacctcc tctaagagcc ctcccagaaa aataaattca tcacccaatg ttaatactac   2760

tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca attccagatg atgataatga   2820

aagactctcg aaagttgaaa aagctagaca gctaagagaa caagtgaatg acctctttag   2880

tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg aaagttccct acaggaaaat   2940

cacaattaac cctggctgtg tggtggttga tggcatgccc ccgggggtgt ccttcaaagc   3000

ccccagctac ctggaaatca gctccatgag aaggatctta gactctgccg agtttatcaa   3060

attcacggtc attagaccat ttccaggact tgtgattaat aaccagctgg ttgatcagag   3120

tgagtcagaa ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc   3180

cacagaaggt aaaaggacct cttccctcct agggtaaatc agcttctgtg tcagggatgc   3240

tgtgtggtgt ccatctgaac cccctgcata cgcgtagcta atgtgatctc cccactttca   3300

cataagatgg tggccctgcc ttcagggaat gtgggagcca ggtgggagcc ttcccggata   3360

tttaagctag aagattctac agggagattc tccttggatc aatatatgtc tctcagtcaa   3420

agatgtaaaa gcacttttgc cttaaaaaga atgttctgtt tctaaataga gtcaacgttg   3480

tcctcctcat tggaattcac tatgagtcag aatcattaga ctgacttttt tttttccata   3540

gtaatagtat tttgcagagt ctcacagagc tgcagatctt ttgttcatct tgcagagtta   3600

acaagtctga tcctgttagt ccagatttct taaatttggc caagttataa taggagcagt   3660

agcttgagac ccgaagtcag gaaactttga caatggattt ttttttttaa tccagagact   3720

tgtactggaa tttgccttac cctgtcagct catggactta aggtttcatc ccgctttatg   3780

agtgcttctg aatccaagtc attgttacct gaatttgcaa attaagttgt gatattcgtg   3840

actgttaaat tcctgtaatt agattaacct ctttgcttgc ttgtttgttt tctctcctat   3900

tttagcttaa agtatcagtg gttgagaaga gcttttcgga cctgttacta ccccaagctg   3960

tgtaatatac ttgtataaca gaaatacctt ctatacaaac ctttttttct acttttagat   4020

agaaatgtct actttttcag cagttctgtg aattaaagag cagagtgact gtgggtctgg   4080

aatggctggt gtacttggga atgtactatc aggattttac agcaatgctg ggaaatgaca   4140

gggaaaatga caggaatgaa tctcaccaga ttttttatgt actcagcaga gccttgagtt   4200

acggtgttta ttttccaatc aagtgaagat atctcctact tctcctactg gaacatctca   4260

gcttctgcag tgaagaaaaa ttcctgtgat agttcagttc tttagttttt ctatttgaaa   4320

aaaaaaaatc atttaaatga tcctttgttc acggctctcc ttaatgactg agtgaacagt   4380

tcctatctgt atatttgact aaaccttttc ctaagctatc tctcatggtt cctatgtttt   4440

tttatcataa ttaaaagcaa aaccatctgg atcacctaac agtcagaggt cagtatctca   4500

gcgtgtgaat tatagaggaa atacagagag aacctcttcc acttttactt ttcgtccaaa   4560

taaaatgcat ggtgtaccag aagttgaaga tcgggttgag gattggggct agctcgatga   4620

cactaaggcc ccaacatcgc gggacctgct gtggcgcgga ttcttaggaa cgctgttcta   4680

gccggccccc tctccagggg tcgccgtggc cggcattatt tcctagttct tcttgtaacc   4740

ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc taaggatgca acctctgacg   4800

ttctgcgcct tcctaggaga gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt   4860

aaaataccag ctctacaaga agctaggctc tgtgacggca tagttttcag tagctttatc   4920

acaatattca caatggagaa ttatatgaca tggtagcaga aataggccct tttatgtgtt   4980

gcttctattt tacctcaaat tgtagatata gggtaatcaa taaaatccat ccatgccttt   5040

cacacactaa gt                                                       5052


<210>  4021
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  4021

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
465                 470                 475                 480


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
                485                 490                 495


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
            500                 505                 510


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
        515                 520                 525


Ser Ser Leu Leu Lys Asn Leu Asn 
    530                 535


<210>  4022
<211>  4084
<212>  DNA
<213>  Homo sapiens

<400>  4022
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1920

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   1980

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttga   2040

aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg aactagttat   2100

ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc agtcccccaa   2160

aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg   2220

ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga ctaacggttc   2280

taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga atgccaaaat   2340

cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg   2400

ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg aagactttta   2460

tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg gcattccgag   2520

gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa agcccgaaat   2580

gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa aaataaattc   2640

atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca ttcaggtgac   2700

aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac agctaagaga   2760

acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg gttttcctgt   2820

gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg atggcatgcc   2880

cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga gaaggatctt   2940

agactctgcc gagtttatca aattcacggt cattagacca tttccaggac ttgtgattaa   3000

taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat cagctgaacc   3060

aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa gctctcagat   3120

caagcaagaa ccagacccca cgtggtagac ctcttccctc ctaggcttaa agtatcagtg   3180

gttgagaaga gcttttcgga cctgttacta ccccaagctg tagccttgag ttacggtgtt   3240

tattttccaa tcaagtgaag atatctccta cttctcctac tggaacatct cagcttctgc   3300

agtgaagaaa aattcctgtg atagttcagt tctttagttt ttctatttga aaaaaaaaaa   3360

tcatttaaat gatcctttgt tcacggctct ccttaatgac tgagtgaaca gttcctatct   3420

gtatatttga ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt tttttatcat   3480

aattaaaagc aaaaccatct ggatcaccta acagtcagag gtcagtatct cagcgtgtga   3540

attatagagg aaatacagag agaacctctt ccacttttac ttttcgtcca aataaaatgc   3600

atggtgtacc agaagttgaa gatcgggttg aggattgggg ctagctcgat gacactaagg   3660

ccccaacatc gcgggacctg ctgtggcgcg gattcttagg aacgctgttc tagccggccc   3720

cctctccagg ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa ccctgaggtg   3780

ccagcgcggg gagtgaggag gggtcagggg gctaaggatg caacctctga cgttctgcgc   3840

cttcctagga gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc   3900

agctctacaa gaagctaggc tctgtgacgg catagttttc agtagcttta tcacaatatt   3960

cacaatggag aattatatga catggtagca gaaataggcc cttttatgtg ttgcttctat   4020

tttacctcaa attgtagata tagggtaatc aataaaatcc atccatgcct ttcacacact   4080

aagt                                                                4084


<210>  4023
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  4023

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
            500                 505                 510


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
        515                 520                 525


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
    530                 535                 540


Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu 
545                 550                 555                 560


Lys Asn Leu Asn 



<210>  4024
<211>  7980
<212>  DNA
<213>  Homo sapiens

<400>  4024
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1980

aagagatttt taatttgaaa tttgcttaga tttgttgaca gcggtttcct ggagtgctgt   2040

cttgagaacg attctgagga ggctcagcaa gaaagagtgt ttcagttgat tgggtgtgtc   2100

tgtcatggag aaggaactca agctcttgga ctcaccgagg cagtaaaagt accatatcct   2160

gtgtttgaat caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc   2220

cgaagcccta cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa   2280

atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct   2340

agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat   2400

tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc   2460

tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg   2520

agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa   2580

aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg   2640

ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg   2700

ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa   2760

gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc   2820

acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca   2880

tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga   2940

ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg   3000

aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca   3060

attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt caaagccccc   3120

agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc   3180

acggtcatta ggtaagtgag agtttcctgc ttagtcacag gagcgaatct ggagctcatg   3240

aggctgactc ttctaaaatg cagccacagg tagtcatcga atccggcttc ctatgctgtg   3300

caatcaacaa atcaaaataa cttgtgtcat cattagaatg tcagatgtgc ttctacgaac   3360

taagctgact cttttaattc tttggcaaag ggttggcaaa ctaggactgt ttgccaaatt   3420

caggctgcct cctattttta gagtcttcct gaaacacagc tacacccgta ttatccatgg   3480

ctgctttcct gtcacagtga gtaagtagct gggactgaga aggcatggcc tccaaagtct   3540

aaaatattta ctctctagca ctttgtagaa aaaccttagc taggcacagt ggctaacgcc   3600

tgtaatccca gcattttggg aggccaaggc aggcagatca cctgaggtca ggagttccag   3660

accagcctgg ccaacatggt gaaatcccat ctctacaaaa ataaaacagt tagctgggca   3720

tgatggcggg tgcctgtaat cccagctact cgggaggctg aggcaggata gtcgcttgaa   3780

cccaggaggt ggaggttgca atgagccaag atcatgccac tgcactccag cctggacgac   3840

agagtgagac tccatcacaa gaaaaaaaga actttgtcaa cctctgtctt agggcgcctt   3900

gtcacaggct tcgggtcaga cggattcaac cttgcatcag ccatttgtta gccaggtcac   3960

tctgttcttt gtctgtaaat gagattgatc gttgttccca ctgagagtgt cagctccttc   4020

ccgtagagca ggcatgatga ttgtactcac ctctgacacc attgtgagtg ccacattcct   4080

tcccacgtcc ttgtcactgt aagagatgcc cacctgagca ccaaccccag gttatcttcc   4140

cctttgtctt ccagcccccc agaaacagct acgactcaac ctacccaatc atttcatcat   4200

cagattgcca ctgtctctag ttcaggtctc ttgggactgg cactcagaaa tctcataata   4260

aatcctcttg aggcttctca tacactcgtc ttcttccaat cttctttccc tcaaaatctc   4320

atattttggt tccacttcac ccaccgtcat tctccatatc actcccagga gttaggcaaa   4380

aagccccttc cgttcttccg tatgttaaac ttagaatcac tctgttccct gctctgcgtt   4440

tctatttttt gtttttcctc catttactag tagcttaaca ctttctaaca gtgttcttat   4500

tattgatacg tatctatctc ttccataagc ttataaggtc acggataata cttctcattg   4560

tagtacgtaa atgacgtggg ctagatatga gttgaataaa cagttatacc tgtaaattct   4620

tacagagtga aaataaattg ttatacttta caatttgttt ctctctttag accatttcca   4680

ggacttgtga ttaataaccg tgagtatttt gtgaagtgtt ttgtttttgt tttttcctgg   4740

ggtctgacgt gtgtgcgtgt gagtgtgtat acatgcttaa cgtatatcac gttacttcac   4800

ctatgtcagt aaccaggcca aatacttgtt ttagccctca gtaaaaacac caggcacttc   4860

ctagttgtaa aattattcaa gcttcttaac ttcctatcct cgatgcactt aatcataaaa   4920

tggtaataat agcaccgatt ttgggggagt cgttccagta gatggaaagc atctggaaca   4980

ggtgtcagca agctcctgcc gacgtgtatg cataaagttt tattgaaacc accatcgtgt   5040

ccatttgttt atggcagaac tgagagatgg cagcagcaag tgtgtgcctg caaaacctaa   5100

aatatttact aattggctct gcaagaaaag agtttgcatc cccctaacct agaacagtgt   5160

ctagcctcta gtatgtgttt agcctacagt atgtgctcag cgaatacaat ctatatttat   5220

tactgctttt atgactgtta taattactgt gcttggattt cgttacaaag taagtcacaa   5280

tgtgcctgct tctgttagta tttcagcaca gtgcctggca cacatggggc tctcaaatat   5340

tgctgagcga gtgaacaaat gtcctttcaa ttccttaacg ttgatgtcat tttcaatagt   5400

attttgagcc aaacttaatt ttgcgagtgt gttttgtttt cttaacttta ttattaaaaa   5460

tgtataaaag tgaggccagg cgtggtggct cacgcctgta atcccagcag tttgggaggc   5520

tgaggcaggc ggatcagttg aggttgggag ttggagacca gcccgtccaa catggtgaaa   5580

gcctgtctct actaaaaata caaaaatcag ctgggtgtgg tggcgcgtgc ctgtaatccc   5640

agctactcag gaggctgagg caggagagtt gcttgaatcc tagaggtgga ggttgcagtg   5700

agctgagatc gtgccattgc actccagcct gggcaacaag agcaaaactc tgtcccaata   5760

aataaataaa taaaatgttc tcttttgttc ctgttcttgt gcggtagtgt ggtatagagt   5820

tttatggtaa ttactgtgaa ttagtgattc tgagggacat atcagaactc tgaggtttgt   5880

ttccttctca tcttgaggga aacagcaaat gtatgttaaa atgcttttcc aagggaacaa   5940

cacatcctta cattatttaa accaatctgc ttcattttca gagctggttg atcagagtga   6000

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   6060

agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag accccacgtg   6120

gtagacctct tccctcctag ggtaaatcag cttctgtgtc agggatgctg tgtggtgtcc   6180

atctgaaccc cctgcatacg cgtagctaat gtgatctccc cactttcaca taagatggtg   6240

gccctgcctt cagggaatgt gggagccagg tgggagcctt cccggatatt taagctagaa   6300

gattctacag ggagattctc cttggatcaa tatatgtctc tcagtcaaag atgtaaaagc   6360

acttttgcct taaaaagaat gttctgtttc taaatagagt caacgttgtc ctcctcattg   6420

gaattcacta tgagtcagaa tcattagact gacttttttt tttccatagt aatagtattt   6480

tgcagagtct cacagagctg cagatctttt gttcatcttg cagagttaac aagtctgatc   6540

ctgttagtcc agatttctta aatttggcca agttataata ggagcagtag cttgagaccc   6600

gaagtcagga aactttgaca atggattttt ttttttaatc cagagacttg tactggaatt   6660

tgccttaccc tgtcagctca tggacttaag gtttcatccc gctttatgag tgcttctgaa   6720

tccaagtcat tgttacctga atttgcaaat taagttgtga tattcgtgac tgttaaattc   6780

ctgtaattag attaacctct ttgcttgctt gtttgttttc tctcctattt tagcttaaag   6840

tatcagtggt tgagaagagc ttttcggacc tgttactacc ccaagctgtg taatatactt   6900

gtataacaga aataccttct atacaaacct ttttttctac ttttagatag aaatgtctac   6960

tttttcagca gttctgtgaa ttaaagagca gagtgactgt gggtctggaa tggctggtgt   7020

acttgggaat gtactatcag gattttacag caatgctggg aaatgacagg gaaaatgaca   7080

ggaatgaatc tcaccagatt ttttatgtac tcagcagagc cttgagttac ggtgtttatt   7140

ttccaatcaa gtgaagatat ctcctacttc tcctactgga acatctcagc ttctgcagtg   7200

aagaaaaatt cctgtgatag ttcagttctt tagtttttct atttgaaaaa aaaaaatcat   7260

ttaaatgatc ctttgttcac ggctctcctt aatgactgag tgaacagttc ctatctgtat   7320

atttgactaa accttttcct aagctatctc tcatggttcc tatgtttttt tatcataatt   7380

aaaagcaaaa ccatctggat cacctaacag tcagaggtca gtatctcagc gtgtgaatta   7440

tagaggaaat acagagagaa cctcttccac ttttactttt cgtccaaata aaatgcatgg   7500

tgtaccagaa gttgaagatc gggttgagga ttggggctag ctcgatgaca ctaaggcccc   7560

aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg ctgttctagc cggccccctc   7620

tccaggggtc gccgtggccg gcattatttc ctagttcttc ttgtaaccct gaggtgccag   7680

cgcggggagt gaggaggggt cagggggcta aggatgcaac ctctgacgtt ctgcgccttc   7740

ctaggagagt cttacatgtg ttgagatttc acaagcaatg cgagttgtaa aataccagct   7800

ctacaagaag ctaggctctg tgacggcata gttttcagta gctttatcac aatattcaca   7860

atggagaatt atatgacatg gtagcagaaa taggcccttt tatgtgttgc ttctatttta   7920

cctcaaattg tagatatagg gtaatcaata aaatccatcc atgcctttca cacactaagt   7980


<210>  4025
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  4025

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
    450                 455                 460


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
465                 470


<210>  4026
<211>  4187
<212>  DNA
<213>  Homo sapiens

<400>  4026
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1980

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   2040

catatcctgt gtttgaatca aacccggagt tcttgtatgt ggaaggcttg ccagagggga   2100

ttcccttccg aagccctacc tggtttggaa ttccacgact tgaaaggatc gtccgcggga   2160

gtaataaaat caagttcgtt gttaaaaaac ctgaactagt tatttcctac ttgcctcctg   2220

ggatggctag taaaataaac actaaagctt tgcagtcccc caaaagacca cgaagtcctg   2280

ggagtaattc aaaggttcct gaaattgagg tcaccgtgga aggccctaat aacaacaatc   2340

ctcaaacctc agctgttcga accccgaccc agactaacgg ttctaacgtt cccttcaagc   2400

cacgagggag agagttttcc tttgaggcct ggaatgccaa aatcacggac ctaaaacaga   2460

aagttgaaaa tctcttcaat gagaaatgtg gggaagctct tggccttaaa caagctgtga   2520

aggtgccgtt cgcgttattt gagtctttcc cggaagactt ttatgtggaa ggcttacctg   2580

agggtgtgcc attccgaaga ccatcgactt ttggcattcc gaggctggag aagatactca   2640

gaaacaaagc caaaattaag ttcatcatta aaaagcccga aatgtttgag acggcgatta   2700

aggagagcac ctcctctaag agccctccca gaaaaataaa ttcatcaccc aatgttaata   2760

ctactgcatc aggtgttgaa gaccttaaca tcattcaggt gacaattcca gatgatgata   2820

atgaaagact ctcgaaagtt gaaaaagcta gacagctaag agaacaagtg aatgacctct   2880

ttagtcggaa atttggtgaa gctattggta tgggttttcc tgtgaaagtt ccctacagga   2940

aaatcacaat taaccctggc tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca   3000

aagcccccag ctacctggaa atcagctcca tgagaaggat cttagactct gccgagttta   3060

tcaaattcac ggtcattaga ccatttccag gacttgtgat taataaccag ctggttgatc   3120

agagtgagtc agaaggcccc gtgatacaag aatcagctga accaagccag ttggaagttc   3180

cagccacaga agaaataaaa gagactgatg gaagctctca gatcaagcaa gaaccagacc   3240

ccacgtggta gacctcttcc ctcctaggct taaagtatca gtggttgaga agagcttttc   3300

ggacctgtta ctaccccaag ctgtagcctt gagttacggt gtttattttc caatcaagtg   3360

aagatatctc ctacttctcc tactggaaca tctcagcttc tgcagtgaag aaaaattcct   3420

gtgatagttc agttctttag tttttctatt tgaaaaaaaa aaatcattta aatgatcctt   3480

tgttcacggc tctccttaat gactgagtga acagttccta tctgtatatt tgactaaacc   3540

ttttcctaag ctatctctca tggttcctat gtttttttat cataattaaa agcaaaacca   3600

tctggatcac ctaacagtca gaggtcagta tctcagcgtg tgaattatag aggaaataca   3660

gagagaacct cttccacttt tacttttcgt ccaaataaaa tgcatggtgt accagaagtt   3720

gaagatcggg ttgaggattg gggctagctc gatgacacta aggccccaac atcgcgggac   3780

ctgctgtggc gcggattctt aggaacgctg ttctagccgg ccccctctcc aggggtcgcc   3840

gtggccggca ttatttccta gttcttcttg taaccctgag gtgccagcgc ggggagtgag   3900

gaggggtcag ggggctaagg atgcaacctc tgacgttctg cgccttccta ggagagtctt   3960

acatgtgttg agatttcaca agcaatgcga gttgtaaaat accagctcta caagaagcta   4020

ggctctgtga cggcatagtt ttcagtagct ttatcacaat attcacaatg gagaattata   4080

tgacatggta gcagaaatag gcccttttat gtgttgcttc tattttacct caaattgtag   4140

atatagggta atcaataaaa tccatccatg cctttcacac actaagt                 4187


<210>  4027
<211>  888
<212>  PRT
<213>  Homo sapiens

<400>  4027

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
    450                 455                 460


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
465                 470                 475                 480


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
                485                 490                 495


Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr 
            500                 505                 510


Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys 
        515                 520                 525


Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro 
    530                 535                 540


Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys 
545                 550                 555                 560


Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val 
                565                 570                 575


Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg 
            580                 585                 590


Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly 
        595                 600                 605


Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys 
    610                 615                 620


Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly 
625                 630                 635                 640


Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro 
                645                 650                 655


Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg 
            660                 665                 670


Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys 
        675                 680                 685


Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala 
    690                 695                 700


Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser 
705                 710                 715                 720


Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile 
                725                 730                 735


Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val 
            740                 745                 750


Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg 
        755                 760                 765


Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr 
    770                 775                 780


Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro 
785                 790                 795                 800


Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met 
                805                 810                 815


Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
            820                 825                 830


Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu 
        835                 840                 845


Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu 
    850                 855                 860


Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile 
865                 870                 875                 880


Lys Gln Glu Pro Asp Pro Thr Trp 
                885


<210>  4028
<211>  4411
<212>  DNA
<213>  Homo sapiens

<400>  4028
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   2040

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2100

taccatatcc tgtgtttgaa tcaaacccgg agttcttgaa aggatcgtcc gcgggagtaa   2160

taaaatcaag ttcgttgtta aaaaacctga actagttatt tcctacttgc ctcctgggat   2220

ggctagtaaa ataaacacta aagctttgca gtcccccaaa agaccacgaa gtcctgggag   2280

taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc cctaataaca acaatcctca   2340

aacctcagct gttcgaaccc cgacccagac taacggttct aacgttccct tcaagccacg   2400

agggagagag ttttcctttg aggcctggaa tgccaaaatc acggacctaa aacagaaagt   2460

tgaaaatctc ttcaatgaga aatgtgggga agctcttggc cttaaacaag ctgtgaaggt   2520

gccgttcgcg ttatttgagt ctttcccgga agacttttat gtggaaggct tacctgaggg   2580

tgtgccattc cgaagaccat cgacttttgg cattccgagg ctggagaaga tactcagaaa   2640

caaagccaaa attaagttca tcattaaaaa gcccgaaatg tttgagacgg cgattaagga   2700

gagcacctcc tctaagagcc ctcccagaaa aataaattca tcacccaatg ttaatactac   2760

tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca attccagatg atgataatga   2820

aagactctcg aaagttgaaa aagctagaca gctaagagaa caagtgaatg acctctttag   2880

tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg aaagttccct acaggaaaat   2940

cacaattaac cctggctgtg tggtggttga tggcatgccc ccgggggtgt ccttcaaagc   3000

ccccagctac ctggaaatca gctccatgag aaggatctta gactctgccg agtttatcaa   3060

attcacggtc attagaccat ttccaggact tgtgattaat aaccagctgg ttgatcagag   3120

tgagtcagaa ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc   3180

cacagaagaa ataaaagaga ctgatggaag ctctcagatc aagcaagaac cagaccccac   3240

gtggtagacc tcttccctcc taggcttaaa gtatcagtgg ttgagaagag cttttcggac   3300

ctgttactac cccaagctgt gtaatatact tgtataacag aaataccttc tatacaaacc   3360

tttttttcta cttttagata gaaatgtcta ctttttcagc agttctgtga attaaagagc   3420

agagtgactg tgggtctgga atggctggtg tacttgggaa tgtactatca ggattttaca   3480

gcaatgctgg gaaatgacag ggaaaatgac aggaatgaat ctcaccagat tttttatgta   3540

ctcagcagag ccttgagtta cggtgtttat tttccaatca agtgaagata tctcctactt   3600

ctcctactgg aacatctcag cttctgcagt gaagaaaaat tcctgtgata gttcagttct   3660

ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat cctttgttca cggctctcct   3720

taatgactga gtgaacagtt cctatctgta tatttgacta aaccttttcc taagctatct   3780

ctcatggttc ctatgttttt ttatcataat taaaagcaaa accatctgga tcacctaaca   3840

gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa tacagagaga acctcttcca   3900

cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga agttgaagat cgggttgagg   3960

attggggcta gctcgatgac actaaggccc caacatcgcg ggacctgctg tggcgcggat   4020

tcttaggaac gctgttctag ccggccccct ctccaggggt cgccgtggcc ggcattattt   4080

cctagttctt cttgtaaccc tgaggtgcca gcgcggggag tgaggagggg tcagggggct   4140

aaggatgcaa cctctgacgt tctgcgcctt cctaggagag tcttacatgt gttgagattt   4200

cacaagcaat gcgagttgta aaataccagc tctacaagaa gctaggctct gtgacggcat   4260

agttttcagt agctttatca caatattcac aatggagaat tatatgacat ggtagcagaa   4320

ataggccctt ttatgtgttg cttctatttt acctcaaatt gtagatatag ggtaatcaat   4380

aaaatccatc catgcctttc acacactaag t                                  4411


<210>  4029
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  4029

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
465                 470                 475                 480


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
                485                 490                 495


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
            500                 505                 510


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
        515                 520                 525


Ser Ser Leu Leu Lys Asn Leu Asn 
    530                 535


<210>  4030
<211>  4330
<212>  DNA
<213>  Homo sapiens

<400>  4030
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   2040

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gcttagattt   2100

gttgacagcg gtttcctgga gtgctgtctt gagaacgatt ctgaggaggc tcagcaagaa   2160

agagtgtttc agttgattgg gtgtgtctgt catggagaag gaactcaagc tcttggactc   2220

accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgtatgtg   2280

gaaggcttgc cagaggggat tcccttccga agccctacct ggtttggaat tccacgactt   2340

gaaaggatcg tccgcgggag taataaaatc aagttcgttg ttaaaaaacc tgaactagtt   2400

atttcctact tgcctcctgg gatggctagt aaaataaaca ctaaagcttt gcagtccccc   2460

aaaagaccac gaagtcctgg gagtaattca aaggttcctg aaattgaggt caccgtggaa   2520

ggccctaata acaacaatcc tcaaacctca gctgttcgaa ccccgaccca gactaacggt   2580

tctaacgttc ccttcaagcc acgagggaga gagttttcct ttgaggcctg gaatgccaaa   2640

atcacggacc taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg ggaagctctt   2700

ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg agtctttccc ggaagacttt   2760

tatgtggaag gcttacctga gggtgtgcca ttccgaagac catcgacttt tggcattccg   2820

aggctggaga agatactcag aaacaaagcc aaaattaagt tcatcattaa aaagcccgaa   2880

atgtttgaga cggcgattaa ggagagcacc tcctctaaga gccctcccag aaaaataaat   2940

tcatcaccca atgttaatac tactgcatca ggtgttgaag accttaacat cattcaggtg   3000

acaattccag atgatgataa tgaaagactc tcgaaagttg aaaaagctag acagctaaga   3060

gaacaagtga atgacctctt tagtcggaaa tttggtgaag ctattggtat gggttttcct   3120

gtgaaagttc cctacaggaa aatcacaatt aaccctggct gtgtggtggt tgatggcatg   3180

cccccggggg tgtccttcaa agcccccagc tacctggaaa tcagctccat gagaaggatc   3240

ttagactctg ccgagtttat caaattcacg gtcattagac catttccagg acttgtgatt   3300

aataaccagc tggttgatca gagtgagtca gaaggccccg tgatacaaga atcagctgaa   3360

ccaagccagt tggaagttcc agccacagaa gaaataaaag agactgatgg aagctctcag   3420

atcaagcaag aaccagaccc cacgtggtag acctcttccc tcctaggagc cttgagttac   3480

ggtgtttatt ttccaatcaa gtgaagatat ctcctacttc tcctactgga acatctcagc   3540

ttctgcagtg aagaaaaatt cctgtgatag ttcagttctt tagtttttct atttgaaaaa   3600

aaaaaatcat ttaaatgatc ctttgttcac ggctctcctt aatgactgag tgaacagttc   3660

ctatctgtat atttgactaa accttttcct aagctatctc tcatggttcc tatgtttttt   3720

tatcataatt aaaagcaaaa ccatctggat cacctaacag tcagaggtca gtatctcagc   3780

gtgtgaatta tagaggaaat acagagagaa cctcttccac ttttactttt cgtccaaata   3840

aaatgcatgg tgtaccagaa gttgaagatc gggttgagga ttggggctag ctcgatgaca   3900

ctaaggcccc aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg ctgttctagc   3960

cggccccctc tccaggggtc gccgtggccg gcattatttc ctagttcttc ttgtaaccct   4020

gaggtgccag cgcggggagt gaggaggggt cagggggcta aggatgcaac ctctgacgtt   4080

ctgcgccttc ctaggagagt cttacatgtg ttgagatttc acaagcaatg cgagttgtaa   4140

aataccagct ctacaagaag ctaggctctg tgacggcata gttttcagta gctttatcac   4200

aatattcaca atggagaatt atatgacatg gtagcagaaa taggcccttt tatgtgttgc   4260

ttctatttta cctcaaattg tagatatagg gtaatcaata aaatccatcc atgcctttca   4320

cacactaagt                                                          4330


<210>  4031
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  4031

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala 



<210>  4032
<211>  7968
<212>  DNA
<213>  Homo sapiens

<400>  4032
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2100

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2160

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2220

tgaatcaaac ccggagttct tgaaaggatc gtccgcggga gtaataaaat caagttcgtt   2280

gttaaaaaac ctgaactagt tatttcctac ttgcctcctg ggatggctag taaaataaac   2340

actaaagctt tgcagtcccc caaaagacca cgaagtcctg ggagtaattc aaaggttcct   2400

gaaattgagg tcaccgtgga aggccctaat aacaacaatc ctcaaacctc agctgttcga   2460

accccgaccc agactaacgg ttctaacgtt cccttcaagc cacgagggag agagttttcc   2520

tttgaggcct ggaatgccaa aatcacggac ctaaaacaga aagttgaaaa tctcttcaat   2580

gagaaatgtg gggaagctct tggccttaaa caagctgtga aggtgccgtt cgcgttattt   2640

gagtctttcc cggaagactt ttatgtggaa ggcttacctg agggtgtgcc attccgaaga   2700

ccatcgactt ttggcattcc gaggctggag aagatactca gaaacaaagc caaaattaag   2760

ttcatcatta aaaagcccga aatgtttgag acggcgatta aggagagcac ctcctctaag   2820

agccctccca gaaaaataaa ttcatcaccc aatgttaata ctactgcatc aggtgttgaa   2880

gaccttaaca tcattcaggt gacaattcca gatgatgata atgaaagact ctcgaaagtt   2940

gaaaaagcta gacagctaag agaacaagtg aatgacctct ttagtcggaa atttggtgaa   3000

gctattggta tgggttttcc tgtgaaagtt ccctacagga aaatcacaat taaccctggc   3060

tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca aagcccccag ctacctggaa   3120

atcagctcca tgagaaggat cttagactct gccgagttta tcaaattcac ggtcattagg   3180

taagtgagag tttcctgctt agtcacagga gcgaatctgg agctcatgag gctgactctt   3240

ctaaaatgca gccacaggta gtcatcgaat ccggcttcct atgctgtgca atcaacaaat   3300

caaaataact tgtgtcatca ttagaatgtc agatgtgctt ctacgaacta agctgactct   3360

tttaattctt tggcaaaggg ttggcaaact aggactgttt gccaaattca ggctgcctcc   3420

tatttttaga gtcttcctga aacacagcta cacccgtatt atccatggct gctttcctgt   3480

cacagtgagt aagtagctgg gactgagaag gcatggcctc caaagtctaa aatatttact   3540

ctctagcact ttgtagaaaa accttagcta ggcacagtgg ctaacgcctg taatcccagc   3600

attttgggag gccaaggcag gcagatcacc tgaggtcagg agttccagac cagcctggcc   3660

aacatggtga aatcccatct ctacaaaaat aaaacagtta gctgggcatg atggcgggtg   3720

cctgtaatcc cagctactcg ggaggctgag gcaggatagt cgcttgaacc caggaggtgg   3780

aggttgcaat gagccaagat catgccactg cactccagcc tggacgacag agtgagactc   3840

catcacaaga aaaaaagaac tttgtcaacc tctgtcttag ggcgccttgt cacaggcttc   3900

gggtcagacg gattcaacct tgcatcagcc atttgttagc caggtcactc tgttctttgt   3960

ctgtaaatga gattgatcgt tgttcccact gagagtgtca gctccttccc gtagagcagg   4020

catgatgatt gtactcacct ctgacaccat tgtgagtgcc acattccttc ccacgtcctt   4080

gtcactgtaa gagatgccca cctgagcacc aaccccaggt tatcttcccc tttgtcttcc   4140

agccccccag aaacagctac gactcaacct acccaatcat ttcatcatca gattgccact   4200

gtctctagtt caggtctctt gggactggca ctcagaaatc tcataataaa tcctcttgag   4260

gcttctcata cactcgtctt cttccaatct tctttccctc aaaatctcat attttggttc   4320

cacttcaccc accgtcattc tccatatcac tcccaggagt taggcaaaaa gccccttccg   4380

ttcttccgta tgttaaactt agaatcactc tgttccctgc tctgcgtttc tattttttgt   4440

ttttcctcca tttactagta gcttaacact ttctaacagt gttcttatta ttgatacgta   4500

tctatctctt ccataagctt ataaggtcac ggataatact tctcattgta gtacgtaaat   4560

gacgtgggct agatatgagt tgaataaaca gttatacctg taaattctta cagagtgaaa   4620

ataaattgtt atactttaca atttgtttct ctctttagac catttccagg acttgtgatt   4680

aataaccgtg agtattttgt gaagtgtttt gtttttgttt tttcctgggg tctgacgtgt   4740

gtgcgtgtga gtgtgtatac atgcttaacg tatatcacgt tacttcacct atgtcagtaa   4800

ccaggccaaa tacttgtttt agccctcagt aaaaacacca ggcacttcct agttgtaaaa   4860

ttattcaagc ttcttaactt cctatcctcg atgcacttaa tcataaaatg gtaataatag   4920

caccgatttt gggggagtcg ttccagtaga tggaaagcat ctggaacagg tgtcagcaag   4980

ctcctgccga cgtgtatgca taaagtttta ttgaaaccac catcgtgtcc atttgtttat   5040

ggcagaactg agagatggca gcagcaagtg tgtgcctgca aaacctaaaa tatttactaa   5100

ttggctctgc aagaaaagag tttgcatccc cctaacctag aacagtgtct agcctctagt   5160

atgtgtttag cctacagtat gtgctcagcg aatacaatct atatttatta ctgcttttat   5220

gactgttata attactgtgc ttggatttcg ttacaaagta agtcacaatg tgcctgcttc   5280

tgttagtatt tcagcacagt gcctggcaca catggggctc tcaaatattg ctgagcgagt   5340

gaacaaatgt cctttcaatt ccttaacgtt gatgtcattt tcaatagtat tttgagccaa   5400

acttaatttt gcgagtgtgt tttgttttct taactttatt attaaaaatg tataaaagtg   5460

aggccaggcg tggtggctca cgcctgtaat cccagcagtt tgggaggctg aggcaggcgg   5520

atcagttgag gttgggagtt ggagaccagc ccgtccaaca tggtgaaagc ctgtctctac   5580

taaaaataca aaaatcagct gggtgtggtg gcgcgtgcct gtaatcccag ctactcagga   5640

ggctgaggca ggagagttgc ttgaatccta gaggtggagg ttgcagtgag ctgagatcgt   5700

gccattgcac tccagcctgg gcaacaagag caaaactctg tcccaataaa taaataaata   5760

aaatgttctc ttttgttcct gttcttgtgc ggtagtgtgg tatagagttt tatggtaatt   5820

actgtgaatt agtgattctg agggacatat cagaactctg aggtttgttt ccttctcatc   5880

ttgagggaaa cagcaaatgt atgttaaaat gcttttccaa gggaacaaca catccttaca   5940

ttatttaaac caatctgctt cattttcaga gctggttgat cagagtgagt cagaaggccc   6000

cgtgatacaa gaatcagctg aaccaagcca gttggaagtt ccagccacag aagaaataaa   6060

agagactgat ggaagctctc agatcaagca agaaccagac cccacgtggt agacctcttc   6120

cctcctaggg taaatcagct tctgtgtcag ggatgctgtg tggtgtccat ctgaaccccc   6180

tgcatacgcg tagctaatgt gatctcccca ctttcacata agatggtggc cctgccttca   6240

gggaatgtgg gagccaggtg ggagccttcc cggatattta agctagaaga ttctacaggg   6300

agattctcct tggatcaata tatgtctctc agtcaaagat gtaaaagcac ttttgcctta   6360

aaaagaatgt tctgtttcta aatagagtca acgttgtcct cctcattgga attcactatg   6420

agtcagaatc attagactga cttttttttt tccatagtaa tagtattttg cagagtctca   6480

cagagctgca gatcttttgt tcatcttgca gagttaacaa gtctgatcct gttagtccag   6540

atttcttaaa tttggccaag ttataatagg agcagtagct tgagacccga agtcaggaaa   6600

ctttgacaat ggattttttt ttttaatcca gagacttgta ctggaatttg ccttaccctg   6660

tcagctcatg gacttaaggt ttcatcccgc tttatgagtg cttctgaatc caagtcattg   6720

ttacctgaat ttgcaaatta agttgtgata ttcgtgactg ttaaattcct gtaattagat   6780

taacctcttt gcttgcttgt ttgttttctc tcctatttta gcttaaagta tcagtggttg   6840

agaagagctt ttcggacctg ttactacccc aagctgtgta atatacttgt ataacagaaa   6900

taccttctat acaaaccttt ttttctactt ttagatagaa atgtctactt tttcagcagt   6960

tctgtgaatt aaagagcaga gtgactgtgg gtctggaatg gctggtgtac ttgggaatgt   7020

actatcagga ttttacagca atgctgggaa atgacaggga aaatgacagg aatgaatctc   7080

accagatttt ttatgtactc agcagagcct tgagttacgg tgtttatttt ccaatcaagt   7140

gaagatatct cctacttctc ctactggaac atctcagctt ctgcagtgaa gaaaaattcc   7200

tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct   7260

ttgttcacgg ctctccttaa tgactgagtg aacagttcct atctgtatat ttgactaaac   7320

cttttcctaa gctatctctc atggttccta tgttttttta tcataattaa aagcaaaacc   7380

atctggatca cctaacagtc agaggtcagt atctcagcgt gtgaattata gaggaaatac   7440

agagagaacc tcttccactt ttacttttcg tccaaataaa atgcatggtg taccagaagt   7500

tgaagatcgg gttgaggatt ggggctagct cgatgacact aaggccccaa catcgcggga   7560

cctgctgtgg cgcggattct taggaacgct gttctagccg gccccctctc caggggtcgc   7620

cgtggccggc attatttcct agttcttctt gtaaccctga ggtgccagcg cggggagtga   7680

ggaggggtca gggggctaag gatgcaacct ctgacgttct gcgccttcct aggagagtct   7740

tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa taccagctct acaagaagct   7800

aggctctgtg acggcatagt tttcagtagc tttatcacaa tattcacaat ggagaattat   7860

atgacatggt agcagaaata ggccctttta tgtgttgctt ctattttacc tcaaattgta   7920

gatatagggt aatcaataaa atccatccat gcctttcaca cactaagt                7968


<210>  4033
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  4033

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys 
        595                 600                 605


Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu 
    610                 615                 620


Asn 
625


<210>  4034
<211>  5028
<212>  DNA
<213>  Homo sapiens

<400>  4034
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagctca   1980

agctcttgga ctcaccgagg cagtaaaagt accatatcct gtgtttgaat caaacccgga   2040

gttcttgtat gtggaaggct tgccagaggg gattcccttc cgaagcccta cctggtttgg   2100

aattccacga cttgaaagga tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa   2160

acctgaacta gttatttcct acttgcctcc tgggatggct agtaaaataa acactaaagc   2220

tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga   2280

ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc tcagctgttc gaaccccgac   2340

ccagactaac ggttctaacg ttcccttcaa gccacgaggg agagagtttt cctttgaggc   2400

ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa aatctcttca atgagaaatg   2460

tggggaagct cttggcctta aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt   2520

cccggaagac ttttatgtgg aaggcttacc tgagggtgtg ccattccgaa gaccatcgac   2580

ttttggcatt ccgaggctgg agaagatact cagaaacaaa gccaaaatta agttcatcat   2640

taaaaagccc gaaatgtttg agacggcgat taaggagagc acctcctcta agagccctcc   2700

cagaaaaata aattcatcac ccaatgttaa tactactgca tcaggtgttg aagaccttaa   2760

catcattcag gtgacaattc cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc   2820

tagacagcta agagaacaag tgaatgacct ctttagtcgg aaatttggtg aagctattgg   2880

tatgggtttt cctgtgaaag ttccctacag gaaaatcaca attaaccctg gctgtgtggt   2940

ggttgatggc atgcccccgg gggtgtcctt caaagccccc agctacctgg aaatcagctc   3000

catgagaagg atcttagact ctgccgagtt tatcaaattc acggtcatta gaccatttcc   3060

aggacttgtg attaataacc agctggttga tcagagtgag tcagaaggcc ccgtgataca   3120

agaatcagct gaaccaagcc agttggaagt tccagccaca gaaggtaaaa ggacctcttc   3180

cctcctaggg taaatcagct tctgtgtcag ggatgctgtg tggtgtccat ctgaaccccc   3240

tgcatacgcg tagctaatgt gatctcccca ctttcacata agatggtggc cctgccttca   3300

gggaatgtgg gagccaggtg ggagccttcc cggatattta agctagaaga ttctacaggg   3360

agattctcct tggatcaata tatgtctctc agtcaaagat gtaaaagcac ttttgcctta   3420

aaaagaatgt tctgtttcta aatagagtca acgttgtcct cctcattgga attcactatg   3480

agtcagaatc attagactga cttttttttt tccatagtaa tagtattttg cagagtctca   3540

cagagctgca gatcttttgt tcatcttgca gagttaacaa gtctgatcct gttagtccag   3600

atttcttaaa tttggccaag ttataatagg agcagtagct tgagacccga agtcaggaaa   3660

ctttgacaat ggattttttt ttttaatcca gagacttgta ctggaatttg ccttaccctg   3720

tcagctcatg gacttaaggt ttcatcccgc tttatgagtg cttctgaatc caagtcattg   3780

ttacctgaat ttgcaaatta agttgtgata ttcgtgactg ttaaattcct gtaattagat   3840

taacctcttt gcttgcttgt ttgttttctc tcctatttta gcttaaagta tcagtggttg   3900

agaagagctt ttcggacctg ttactacccc aagctgtgta atatacttgt ataacagaaa   3960

taccttctat acaaaccttt ttttctactt ttagatagaa atgtctactt tttcagcagt   4020

tctgtgaatt aaagagcaga gtgactgtgg gtctggaatg gctggtgtac ttgggaatgt   4080

actatcagga ttttacagca atgctgggaa atgacaggga aaatgacagg aatgaatctc   4140

accagatttt ttatgtactc agcagagcct tgagttacgg tgtttatttt ccaatcaagt   4200

gaagatatct cctacttctc ctactggaac atctcagctt ctgcagtgaa gaaaaattcc   4260

tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct   4320

ttgttcacgg ctctccttaa tgactgagtg aacagttcct atctgtatat ttgactaaac   4380

cttttcctaa gctatctctc atggttccta tgttttttta tcataattaa aagcaaaacc   4440

atctggatca cctaacagtc agaggtcagt atctcagcgt gtgaattata gaggaaatac   4500

agagagaacc tcttccactt ttacttttcg tccaaataaa atgcatggtg taccagaagt   4560

tgaagatcgg gttgaggatt ggggctagct cgatgacact aaggccccaa catcgcggga   4620

cctgctgtgg cgcggattct taggaacgct gttctagccg gccccctctc caggggtcgc   4680

cgtggccggc attatttcct agttcttctt gtaaccctga ggtgccagcg cggggagtga   4740

ggaggggtca gggggctaag gatgcaacct ctgacgttct gcgccttcct aggagagtct   4800

tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa taccagctct acaagaagct   4860

aggctctgtg acggcatagt tttcagtagc tttatcacaa tattcacaat ggagaattat   4920

atgacatggt agcagaaata ggccctttta tgtgttgctt ctattttacc tcaaattgta   4980

gatatagggt aatcaataaa atccatccat gcctttcaca cactaagt                5028


<210>  4035
<211>  923
<212>  PRT
<213>  Homo sapiens

<400>  4035

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
        515                 520                 525


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
    530                 535                 540


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
545                 550                 555                 560


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
                565                 570                 575


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
            580                 585                 590


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
        595                 600                 605


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
    610                 615                 620


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
625                 630                 635                 640


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
                645                 650                 655


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
            660                 665                 670


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
        675                 680                 685


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
    690                 695                 700


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
705                 710                 715                 720


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
                725                 730                 735


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
            740                 745                 750


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
        755                 760                 765


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
    770                 775                 780


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
785                 790                 795                 800


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
                805                 810                 815


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
            820                 825                 830


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
        835                 840                 845


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
    850                 855                 860


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro 
865                 870                 875                 880


Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly 
                885                 890                 895


Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala 
            900                 905                 910


Thr Glu Gly Lys Arg Thr Ser Ser Leu Leu Gly 
        915                 920


<210>  4036
<211>  5100
<212>  DNA
<213>  Homo sapiens

<400>  4036
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   1980

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2040

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2100

atcaaacccg gagttcttgt atgtggaagg cttgccagag gggattccct tccgaagccc   2160

tacctggttt ggaattccac gacttgaaag gatcgtccgc gggagtaata aaatcaagtt   2220

cgttgttaaa aaacctgaac tagttatttc ctacttgcct cctgggatgg ctagtaaaat   2280

aaacactaaa gctttgcagt cccccaaaag accacgaagt cctgggagta attcaaaggt   2340

tcctgaaatt gaggtcaccg tggaaggccc taataacaac aatcctcaaa cctcagctgt   2400

tcgaaccccg acccagacta acggttctaa cgttcccttc aagccacgag ggagagagtt   2460

ttcctttgag gcctggaatg ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt   2520

caatgagaaa tgtggggaag ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt   2580

atttgagtct ttcccggaag acttttatgt ggaaggctta cctgagggtg tgccattccg   2640

aagaccatcg acttttggca ttccgaggct ggagaagata ctcagaaaca aagccaaaat   2700

taagttcatc attaaaaagc ccgaaatgtt tgagacggcg attaaggaga gcacctcctc   2760

taagagccct cccagaaaaa taaattcatc acccaatgtt aatactactg catcaggtgt   2820

tgaagacctt aacatcattc aggtgacaat tccagatgat gataatgaaa gactctcgaa   2880

agttgaaaaa gctagacagc taagagaaca agtgaatgac ctctttagtc ggaaatttgg   2940

tgaagctatt ggtatgggtt ttcctgtgaa agttccctac aggaaaatca caattaaccc   3000

tggctgtgtg gtggttgatg gcatgccccc gggggtgtcc ttcaaagccc ccagctacct   3060

ggaaatcagc tccatgagaa ggatcttaga ctctgccgag tttatcaaat tcacggtcat   3120

tagaccattt ccaggacttg tgattaataa ccagctggtt gatcagagtg agtcagaagg   3180

ccccgtgata caagaatcag ctgaaccaag ccagttggaa gttccagcca cagaaggtaa   3240

aaggacctct tccctcctag ggtaaatcag cttctgtgtc agggatgctg tgtggtgtcc   3300

atctgaaccc cctgcatacg cgtagctaat gtgatctccc cactttcaca taagatggtg   3360

gccctgcctt cagggaatgt gggagccagg tgggagcctt cccggatatt taagctagaa   3420

gattctacag ggagattctc cttggatcaa tatatgtctc tcagtcaaag atgtaaaagc   3480

acttttgcct taaaaagaat gttctgtttc taaatagagt caacgttgtc ctcctcattg   3540

gaattcacta tgagtcagaa tcattagact gacttttttt tttccatagt aatagtattt   3600

tgcagagtct cacagagctg cagatctttt gttcatcttg cagagttaac aagtctgatc   3660

ctgttagtcc agatttctta aatttggcca agttataata ggagcagtag cttgagaccc   3720

gaagtcagga aactttgaca atggattttt ttttttaatc cagagacttg tactggaatt   3780

tgccttaccc tgtcagctca tggacttaag gtttcatccc gctttatgag tgcttctgaa   3840

tccaagtcat tgttacctga atttgcaaat taagttgtga tattcgtgac tgttaaattc   3900

ctgtaattag attaacctct ttgcttgctt gtttgttttc tctcctattt tagcttaaag   3960

tatcagtggt tgagaagagc ttttcggacc tgttactacc ccaagctgtg taatatactt   4020

gtataacaga aataccttct atacaaacct ttttttctac ttttagatag aaatgtctac   4080

tttttcagca gttctgtgaa ttaaagagca gagtgactgt gggtctggaa tggctggtgt   4140

acttgggaat gtactatcag gattttacag caatgctggg aaatgacagg gaaaatgaca   4200

ggaatgaatc tcaccagatt ttttatgtac tcagcagagc cttgagttac ggtgtttatt   4260

ttccaatcaa gtgaagatat ctcctacttc tcctactgga acatctcagc ttctgcagtg   4320

aagaaaaatt cctgtgatag ttcagttctt tagtttttct atttgaaaaa aaaaaatcat   4380

ttaaatgatc ctttgttcac ggctctcctt aatgactgag tgaacagttc ctatctgtat   4440

atttgactaa accttttcct aagctatctc tcatggttcc tatgtttttt tatcataatt   4500

aaaagcaaaa ccatctggat cacctaacag tcagaggtca gtatctcagc gtgtgaatta   4560

tagaggaaat acagagagaa cctcttccac ttttactttt cgtccaaata aaatgcatgg   4620

tgtaccagaa gttgaagatc gggttgagga ttggggctag ctcgatgaca ctaaggcccc   4680

aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg ctgttctagc cggccccctc   4740

tccaggggtc gccgtggccg gcattatttc ctagttcttc ttgtaaccct gaggtgccag   4800

cgcggggagt gaggaggggt cagggggcta aggatgcaac ctctgacgtt ctgcgccttc   4860

ctaggagagt cttacatgtg ttgagatttc acaagcaatg cgagttgtaa aataccagct   4920

ctacaagaag ctaggctctg tgacggcata gttttcagta gctttatcac aatattcaca   4980

atggagaatt atatgacatg gtagcagaaa taggcccttt tatgtgttgc ttctatttta   5040

cctcaaattg tagatatagg gtaatcaata aaatccatcc atgcctttca cacactaagt   5100


<210>  4037
<211>  947
<212>  PRT
<213>  Homo sapiens

<400>  4037

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
                565                 570                 575


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
            580                 585                 590


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
        595                 600                 605


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
    610                 615                 620


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
625                 630                 635                 640


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
                645                 650                 655


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
            660                 665                 670


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
        675                 680                 685


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
    690                 695                 700


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
705                 710                 715                 720


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
                725                 730                 735


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
            740                 745                 750


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
        755                 760                 765


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
    770                 775                 780


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
785                 790                 795                 800


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
                805                 810                 815


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
            820                 825                 830


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
        835                 840                 845


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
    850                 855                 860


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
865                 870                 875                 880


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
                885                 890                 895


Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu 
            900                 905                 910


Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu 
        915                 920                 925


Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Gly Lys Arg Thr Ser Ser 
    930                 935                 940


Leu Leu Gly 
945


<210>  4038
<211>  3788
<212>  DNA
<213>  Homo sapiens

<400>  4038
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1860

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1920

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1980

aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc   2040

ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt   2100

tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa   2160

taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg   2220

ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg   2280

ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga gggagagagt   2340

tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct   2400

tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt   2460

tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc   2520

gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa   2580

ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct   2640

ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg   2700

ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga   2760

aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg   2820

gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc   2880

ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc   2940

tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca   3000

ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt gagtcagaag   3060

gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc acagaagaaa   3120

taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg tggtagacct   3180

cttccctcct aggcaaaacc atctggatca cctaacagtc agaggtcagt atctcagcgt   3240

gtgaattata gaggaaatac agagagaacc tcttccactt ttacttttcg tccaaataaa   3300

atgcatggtg taccagaagt tgaagatcgg gttgaggatt ggggctagct cgatgacact   3360

aaggccccaa catcgcggga cctgctgtgg cgcggattct taggaacgct gttctagccg   3420

gccccctctc caggggtcgc cgtggccggc attatttcct agttcttctt gtaaccctga   3480

ggtgccagcg cggggagtga ggaggggtca gggggctaag gatgcaacct ctgacgttct   3540

gcgccttcct aggagagtct tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa   3600

taccagctct acaagaagct aggctctgtg acggcatagt tttcagtagc tttatcacaa   3660

tattcacaat ggagaattat atgacatggt agcagaaata ggccctttta tgtgttgctt   3720

ctattttacc tcaaattgta gatatagggt aatcaataaa atccatccat gcctttcaca   3780

cactaagt                                                            3788


<210>  4039
<211>  863
<212>  PRT
<213>  Homo sapiens

<400>  4039

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg 
            420                 425                 430


Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe 
        435                 440                 445


Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val 
    450                 455                 460


Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly 
465                 470                 475                 480


Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg 
                485                 490                 495


Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu 
            500                 505                 510


Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr 
        515                 520                 525


Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser 
    530                 535                 540


Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn 
545                 550                 555                 560


Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn 
                565                 570                 575


Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn 
            580                 585                 590


Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu 
        595                 600                 605


Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe 
    610                 615                 620


Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro 
625                 630                 635                 640


Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu 
                645                 650                 655


Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys 
            660                 665                 670


Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser 
        675                 680                 685


Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser 
    690                 695                 700


Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp 
705                 710                 715                 720


Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln 
                725                 730                 735


Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly 
            740                 745                 750


Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys 
        755                 760                 765


Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser 
    770                 775                 780


Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe 
785                 790                 795                 800


Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn 
                805                 810                 815


Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser 
            820                 825                 830


Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu 
        835                 840                 845


Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
    850                 855                 860


<210>  4040
<211>  5131
<212>  DNA
<213>  Homo sapiens

<400>  4040
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1980

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   2040

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttgt   2100

atgtggaagg cttgccagag gggattccct tccgaagccc tacctggttt ggaattccac   2160

gacttgaaag gatcgtccgc gggagtaata aaatcaagtt cgttgttaaa aaacctgaac   2220

tagttatttc ctacttgcct cctgggatgg ctagtaaaat aaacactaaa gctttgcagt   2280

cccccaaaag accacgaagt cctgggagta attcaaaggt tcctgaaatt gaggtcaccg   2340

tggaaggccc taataacaac aatcctcaaa cctcagctgt tcgaaccccg acccagacta   2400

acggttctaa cgttcccttc aagccacgag ggagagagtt ttcctttgag gcctggaatg   2460

ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt caatgagaaa tgtggggaag   2520

ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt atttgagtct ttcccggaag   2580

acttttatgt ggaaggctta cctgagggtg tgccattccg aagaccatcg acttttggca   2640

ttccgaggct ggagaagata ctcagaaaca aagccaaaat taagttcatc attaaaaagc   2700

ccgaaatgtt tgagacggcg attaaggaga gcacctcctc taagagccct cccagaaaaa   2760

taaattcatc acccaatgtt aatactactg catcaggtgt tgaagacctt aacatcattc   2820

aggtgacaat tccagatgat gataatgaaa gactctcgaa agttgaaaaa gctagacagc   2880

taagagaaca agtgaatgac ctctttagtc ggaaatttgg tgaagctatt ggtatgggtt   2940

ttcctgtgaa agttccctac aggaaaatca caattaaccc tggctgtgtg gtggttgatg   3000

gcatgccccc gggggtgtcc ttcaaagccc ccagctacct ggaaatcagc tccatgagaa   3060

ggatcttaga ctctgccgag tttatcaaat tcacggtcat tagaccattt ccaggacttg   3120

tgattaataa ccagctggtt gatcagagtg agtcagaagg ccccgtgata caagaatcag   3180

ctgaaccaag ccagttggaa gttccagcca cagaagaaat aaaagagact gatggaagct   3240

ctcagatcaa gcaagaacca gaccccacgt ggtagacctc ttccctccta gggtaaatca   3300

gcttctgtgt cagggatgct gtgtggtgtc catctgaacc ccctgcatac gcgtagctaa   3360

tgtgatctcc ccactttcac ataagatggt ggccctgcct tcagggaatg tgggagccag   3420

gtgggagcct tcccggatat ttaagctaga agattctaca gggagattct ccttggatca   3480

atatatgtct ctcagtcaaa gatgtaaaag cacttttgcc ttaaaaagaa tgttctgttt   3540

ctaaatagag tcaacgttgt cctcctcatt ggaattcact atgagtcaga atcattagac   3600

tgactttttt ttttccatag taatagtatt ttgcagagtc tcacagagct gcagatcttt   3660

tgttcatctt gcagagttaa caagtctgat cctgttagtc cagatttctt aaatttggcc   3720

aagttataat aggagcagta gcttgagacc cgaagtcagg aaactttgac aatggatttt   3780

tttttttaat ccagagactt gtactggaat ttgccttacc ctgtcagctc atggacttaa   3840

ggtttcatcc cgctttatga gtgcttctga atccaagtca ttgttacctg aatttgcaaa   3900

ttaagttgtg atattcgtga ctgttaaatt cctgtaatta gattaacctc tttgcttgct   3960

tgtttgtttt ctctcctatt ttagcttaaa gtatcagtgg ttgagaagag cttttcggac   4020

ctgttactac cccaagctgt gtaatatact tgtataacag aaataccttc tatacaaacc   4080

tttttttcta cttttagata gaaatgtcta ctttttcagc agttctgtga attaaagagc   4140

agagtgactg tgggtctgga atggctggtg tacttgggaa tgtactatca ggattttaca   4200

gcaatgctgg gaaatgacag ggaaaatgac aggaatgaat ctcaccagat tttttatgta   4260

ctcagcagag ccttgagtta cggtgtttat tttccaatca agtgaagata tctcctactt   4320

ctcctactgg aacatctcag cttctgcagt gaagaaaaat tcctgtgata gttcagttct   4380

ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat cctttgttca cggctctcct   4440

taatgactga gtgaacagtt cctatctgta tatttgacta aaccttttcc taagctatct   4500

ctcatggttc ctatgttttt ttatcataat taaaagcaaa accatctgga tcacctaaca   4560

gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa tacagagaga acctcttcca   4620

cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga agttgaagat cgggttgagg   4680

attggggcta gctcgatgac actaaggccc caacatcgcg ggacctgctg tggcgcggat   4740

tcttaggaac gctgttctag ccggccccct ctccaggggt cgccgtggcc ggcattattt   4800

cctagttctt cttgtaaccc tgaggtgcca gcgcggggag tgaggagggg tcagggggct   4860

aaggatgcaa cctctgacgt tctgcgcctt cctaggagag tcttacatgt gttgagattt   4920

cacaagcaat gcgagttgta aaataccagc tctacaagaa gctaggctct gtgacggcat   4980

agttttcagt agctttatca caatattcac aatggagaat tatatgacat ggtagcagaa   5040

ataggccctt ttatgtgttg cttctatttt acctcaaatt gtagatatag ggtaatcaat   5100

aaaatccatc catgcctttc acacactaag t                                  5131


<210>  4041
<211>  957
<212>  PRT
<213>  Homo sapiens

<400>  4041

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
                565                 570                 575


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
            580                 585                 590


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
        595                 600                 605


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
    610                 615                 620


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
625                 630                 635                 640


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
                645                 650                 655


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
            660                 665                 670


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
        675                 680                 685


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
    690                 695                 700


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
705                 710                 715                 720


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
                725                 730                 735


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
            740                 745                 750


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
        755                 760                 765


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
    770                 775                 780


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
785                 790                 795                 800


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
                805                 810                 815


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
            820                 825                 830


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
        835                 840                 845


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
    850                 855                 860


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
865                 870                 875                 880


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
                885                 890                 895


Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu 
            900                 905                 910


Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu 
        915                 920                 925


Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp 
    930                 935                 940


Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950                 955


<210>  4042
<211>  3794
<212>  DNA
<213>  Homo sapiens

<400>  4042
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   1980

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   2040

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2100

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2160

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2220

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2280

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2340

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2400

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2460

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2520

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2580

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2640

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2700

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2760

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2820

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2880

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   2940

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   3000

cggtcattag accatttcca ggacttgtga ttaataacca gctggttgat cagagtgagt   3060

cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt ccagccacag   3120

aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac cccacgtggt   3180

agacctcttc cctcctaggc aaaaccatct ggatcaccta acagtcagag gtcagtatct   3240

cagcgtgtga attatagagg aaatacagag agaacctctt ccacttttac ttttcgtcca   3300

aataaaatgc atggtgtacc agaagttgaa gatcgggttg aggattgggg ctagctcgat   3360

gacactaagg ccccaacatc gcgggacctg ctgtggcgcg gattcttagg aacgctgttc   3420

tagccggccc cctctccagg ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa   3480

ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg gctaaggatg caacctctga   3540

cgttctgcgc cttcctagga gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt   3600

gtaaaatacc agctctacaa gaagctaggc tctgtgacgg catagttttc agtagcttta   3660

tcacaatatt cacaatggag aattatatga catggtagca gaaataggcc cttttatgtg   3720

ttgcttctat tttacctcaa attgtagata tagggtaatc aataaaatcc atccatgcct   3780

ttcacacact aagt                                                     3794


<210>  4043
<211>  865
<212>  PRT
<213>  Homo sapiens

<400>  4043

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
    450                 455                 460


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
465                 470                 475                 480


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
                485                 490                 495


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
            500                 505                 510


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
        515                 520                 525


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
    530                 535                 540


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
545                 550                 555                 560


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
                565                 570                 575


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
            580                 585                 590


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
        595                 600                 605


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
    610                 615                 620


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
625                 630                 635                 640


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
                645                 650                 655


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
            660                 665                 670


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
        675                 680                 685


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
    690                 695                 700


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
705                 710                 715                 720


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
                725                 730                 735


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
            740                 745                 750


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
        755                 760                 765


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
    770                 775                 780


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
785                 790                 795                 800


Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile 
                805                 810                 815


Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln 
            820                 825                 830


Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile 
        835                 840                 845


Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr 
    850                 855                 860


Trp 
865


<210>  4044
<211>  7315
<212>  DNA
<213>  Homo sapiens

<400>  4044
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   1980

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gcttagattt   2040

gttgacagcg gtttcctgga gtgctgtctt gagaacgatt ctgaggaggc tcagcaagaa   2100

agagtgtttc agttgattgg gtgtgtctgt catggagaag gaactcaagc tcttggactc   2160

accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgtatgtg   2220

gaaggcttgc cagaggggat tcccttccga agccctacct ggtttggaat tccacgactt   2280

gaaaggatcg tccgcgggag taataaaatc aagttcgttg ttaaaaaacc tgaactagtt   2340

atttcctact tgcctcctgg gatggctagt aaaataaaca ctaaagcttt gcagtccccc   2400

aaaagaccac gaagtcctgg gagtaattca aaggttcctg aaattgaggt caccgtggaa   2460

ggccctaata acaacaatcc tcaaacctca gctgttcgaa ccccgaccca gactaacggt   2520

tctaacgttc ccttcaagcc acgagggaga gagttttcct ttgaggcctg gaatgccaaa   2580

atcacggacc taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg ggaagctctt   2640

ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg agtctttccc ggaagacttt   2700

tatgtggaag gcttacctga gggtgtgcca ttccgaagac catcgacttt tggcattccg   2760

aggctggaga agatactcag aaacaaagcc aaaattaagt tcatcattaa aaagcccgaa   2820

atgtttgaga cggcgattaa ggagagcacc tcctctaaga gccctcccag aaaaataaat   2880

tcatcaccca atgttaatac tactgcatca ggtgttgaag accttaacat cattcaggtg   2940

acaattccag atgatgataa tgaaagactc tcgaaagttg aaaaagctag acagctaaga   3000

gaacaagtga atgacctctt tagtcggaaa tttggtgaag ctattggtat gggttttcct   3060

gtgaaagttc cctacaggaa aatcacaatt aaccctggct gtgtggtggt tgatggcatg   3120

cccccggggg tgtccttcaa agcccccagc tacctggaaa tcagctccat gagaaggatc   3180

ttagactctg ccgagtttat caaattcacg gtcattaggt aagtgagagt ttcctgctta   3240

gtcacaggag cgaatctgga gctcatgagg ctgactcttc taaaatgcag ccacaggtag   3300

tcatcgaatc cggcttccta tgctgtgcaa tcaacaaatc aaaataactt gtgtcatcat   3360

tagaatgtca gatgtgcttc tacgaactaa gctgactctt ttaattcttt ggcaaagggt   3420

tggcaaacta ggactgtttg ccaaattcag gctgcctcct atttttagag tcttcctgaa   3480

acacagctac acccgtatta tccatggctg ctttcctgtc acagtgagta agtagctggg   3540

actgagaagg catggcctcc aaagtctaaa atatttactc tctagcactt tgtagaaaaa   3600

ccttagctag gcacagtggc taacgcctgt aatcccagca ttttgggagg ccaaggcagg   3660

cagatcacct gaggtcagga gttccagacc agcctggcca acatggtgaa atcccatctc   3720

tacaaaaata aaacagttag ctgggcatga tggcgggtgc ctgtaatccc agctactcgg   3780

gaggctgagg caggatagtc gcttgaaccc aggaggtgga ggttgcaatg agccaagatc   3840

atgccactgc actccagcct ggacgacaga gtgagactcc atcacaagaa aaaaagaact   3900

ttgtcaacct ctgtcttagg gcgccttgtc acaggcttcg ggtcagacgg attcaacctt   3960

gcatcagcca tttgttagcc aggtcactct gttctttgtc tgtaaatgag attgatcgtt   4020

gttcccactg agagtgtcag ctccttcccg tagagcaggc atgatgattg tactcacctc   4080

tgacaccatt gtgagtgcca cattccttcc cacgtccttg tcactgtaag agatgcccac   4140

ctgagcacca accccaggtt atcttcccct ttgtcttcca gccccccaga aacagctacg   4200

actcaaccta cccaatcatt tcatcatcag attgccactg tctctagttc aggtctcttg   4260

ggactggcac tcagaaatct cataataaat cctcttgagg cttctcatac actcgtcttc   4320

ttccaatctt ctttccctca aaatctcata ttttggttcc acttcaccca ccgtcattct   4380

ccatatcact cccaggagtt aggcaaaaag ccccttccgt tcttccgtat gttaaactta   4440

gaatcactct gttccctgct ctgcgtttct attttttgtt tttcctccat ttactagtag   4500

cttaacactt tctaacagtg ttcttattat tgatacgtat ctatctcttc cataagctta   4560

taaggtcacg gataatactt ctcattgtag tacgtaaatg acgtgggcta gatatgagtt   4620

gaataaacag ttatacctgt aaattcttac agagtgaaaa taaattgtta tactttacaa   4680

tttgtttctc tctttagacc atttccagga cttgtgatta ataaccgtga gtattttgtg   4740

aagtgttttg tttttgtttt ttcctggggt ctgacgtgtg tgcgtgtgag tgtgtataca   4800

tgcttaacgt atatcacgtt acttcaccta tgtcagtaac caggccaaat acttgtttta   4860

gccctcagta aaaacaccag gcacttccta gttgtaaaat tattcaagct tcttaacttc   4920

ctatcctcga tgcacttaat cataaaatgg taataatagc accgattttg ggggagtcgt   4980

tccagtagat ggaaagcatc tggaacaggt gtcagcaagc tcctgccgac gtgtatgcat   5040

aaagttttat tgaaaccacc atcgtgtcca tttgtttatg gcagaactga gagatggcag   5100

cagcaagtgt gtgcctgcaa aacctaaaat atttactaat tggctctgca agaaaagagt   5160

ttgcatcccc ctaacctaga acagtgtcta gcctctagta tgtgtttagc ctacagtatg   5220

tgctcagcga atacaatcta tatttattac tgcttttatg actgttataa ttactgtgct   5280

tggatttcgt tacaaagtaa gtcacaatgt gcctgcttct gttagtattt cagcacagtg   5340

cctggcacac atggggctct caaatattgc tgagcgagtg aacaaatgtc ctttcaattc   5400

cttaacgttg atgtcatttt caatagtatt ttgagccaaa cttaattttg cgagtgtgtt   5460

ttgttttctt aactttatta ttaaaaatgt ataaaagtga ggccaggcgt ggtggctcac   5520

gcctgtaatc ccagcagttt gggaggctga ggcaggcgga tcagttgagg ttgggagttg   5580

gagaccagcc cgtccaacat ggtgaaagcc tgtctctact aaaaatacaa aaatcagctg   5640

ggtgtggtgg cgcgtgcctg taatcccagc tactcaggag gctgaggcag gagagttgct   5700

tgaatcctag aggtggaggt tgcagtgagc tgagatcgtg ccattgcact ccagcctggg   5760

caacaagagc aaaactctgt cccaataaat aaataaataa aatgttctct tttgttcctg   5820

ttcttgtgcg gtagtgtggt atagagtttt atggtaatta ctgtgaatta gtgattctga   5880

gggacatatc agaactctga ggtttgtttc cttctcatct tgagggaaac agcaaatgta   5940

tgttaaaatg cttttccaag ggaacaacac atccttacat tatttaaacc aatctgcttc   6000

attttcagag ctggttgatc agagtgagtc agaaggcccc gtgatacaag aatcagctga   6060

accaagccag ttggaagttc cagccacaga agaaataaaa gagactgatg gaagctctca   6120

gatcaagcaa gaaccagacc ccacgtggta gacctcttcc ctcctaggct taaagtatca   6180

gtggttgaga agagcttttc ggacctgtta ctaccccaag ctgtgtaata tacttgtata   6240

acagaaatac cttctataca aacctttttt tctactttta gatagaaatg tctacttttt   6300

cagcagttct gtgaattaaa gagcagagtg actgtgggtc tggaatggct ggtgtacttg   6360

ggaatgtact atcaggattt tacagcaatg ctgggaaatg acagggaaaa tgacaggaat   6420

gaatctcacc agatttttta tgtactcagc agagccttga gttacggtgt ttattttcca   6480

atcaagtgaa gatatctcct acttctccta ctggaacatc tcagcttctg cagtgaagaa   6540

aaattcctgt gatagttcag ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa   6600

tgatcctttg ttcacggctc tccttaatga ctgagtgaac agttcctatc tgtatatttg   6660

actaaacctt ttcctaagct atctctcatg gttcctatgt ttttttatca taattaaaag   6720

caaaaccatc tggatcacct aacagtcaga ggtcagtatc tcagcgtgtg aattatagag   6780

gaaatacaga gagaacctct tccactttta cttttcgtcc aaataaaatg catggtgtac   6840

cagaagttga agatcgggtt gaggattggg gctagctcga tgacactaag gccccaacat   6900

cgcgggacct gctgtggcgc ggattcttag gaacgctgtt ctagccggcc ccctctccag   6960

gggtcgccgt ggccggcatt atttcctagt tcttcttgta accctgaggt gccagcgcgg   7020

ggagtgagga ggggtcaggg ggctaaggat gcaacctctg acgttctgcg ccttcctagg   7080

agagtcttac atgtgttgag atttcacaag caatgcgagt tgtaaaatac cagctctaca   7140

agaagctagg ctctgtgacg gcatagtttt cagtagcttt atcacaatat tcacaatgga   7200

gaattatatg acatggtagc agaaataggc ccttttatgt gttgcttcta ttttacctca   7260

aattgtagat atagggtaat caataaaatc catccatgcc tttcacacac taagt        7315


<210>  4045
<211>  544
<212>  PRT
<213>  Homo sapiens

<400>  4045

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile 
        515                 520                 525


Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  4046
<211>  4478
<212>  DNA
<213>  Homo sapiens

<400>  4046
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   2040

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2100

taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2160

ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2220

ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2280

ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2340

ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2400

atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2460

agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2520

agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2580

tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2640

ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2700

tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2760

ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2820

atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2880

ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2940

tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   3000

ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   3060

tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3120

ttatcaaatt cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg   3180

atcagagtga gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag   3240

ttccagccac agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag   3300

accccacgtg gtagacctct tccctcctag gcttaaagta tcagtggttg agaagagctt   3360

ttcggacctg ttactacccc aagctgtgta atatacttgt ataacagaaa taccttctat   3420

acaaaccttt ttttctactt ttagatagaa atgtctactt tttcagcagt tctgtgaatt   3480

aaagagcaga gtgactgtgg gtctggaatg gctggtgtac ttgggaatgt actatcagga   3540

ttttacagca atgctgggaa atgacaggga aaatgacagg aatgaatctc accagatttt   3600

ttatgtactc agcagagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct   3660

cctacttctc ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt   3720

cagttcttta gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg   3780

ctctccttaa tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa   3840

gctatctctc atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca   3900

cctaacagtc agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc   3960

tcttccactt ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg   4020

gttgaggatt ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg   4080

cgcggattct taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc   4140

attatttcct agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca   4200

gggggctaag gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt   4260

gagatttcac aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg   4320

acggcatagt tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt   4380

agcagaaata ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt   4440

aatcaataaa atccatccat gcctttcaca cactaagt                           4478


<210>  4047
<211>  909
<212>  PRT
<213>  Homo sapiens

<400>  4047

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
465                 470                 475                 480


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
                485                 490                 495


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
            500                 505                 510


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
        515                 520                 525


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
    530                 535                 540


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
545                 550                 555                 560


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
                565                 570                 575


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
            580                 585                 590


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
        595                 600                 605


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
    610                 615                 620


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
625                 630                 635                 640


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
                645                 650                 655


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
            660                 665                 670


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
        675                 680                 685


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
    690                 695                 700


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
705                 710                 715                 720


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
                725                 730                 735


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
            740                 745                 750


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
        755                 760                 765


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
    770                 775                 780


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
785                 790                 795                 800


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
                805                 810                 815


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
            820                 825                 830


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
        835                 840                 845


Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu 
    850                 855                 860


Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu 
865                 870                 875                 880


Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp 
                885                 890                 895


Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
            900                 905


<210>  4048
<211>  7068
<212>  DNA
<213>  Homo sapiens

<400>  4048
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagctca agctcttgga ctcaccgagg   1920

cagtaaaagt accatatcct gtgtttgaat caaacccgga gttcttgtat gtggaaggct   1980

tgccagaggg gattcccttc cgaagcccta cctggtttgg aattccacga cttgaaagga   2040

tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa acctgaacta gttatttcct   2100

acttgcctcc tgggatggct agtaaaataa acactaaagc tttgcagtcc cccaaaagac   2160

cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta   2220

ataacaacaa tcctcaaacc tcagctgttc gaaccccgac ccagactaac ggttctaacg   2280

ttcccttcaa gccacgaggg agagagtttt cctttgaggc ctggaatgcc aaaatcacgg   2340

acctaaaaca gaaagttgaa aatctcttca atgagaaatg tggggaagct cttggcctta   2400

aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg   2460

aaggcttacc tgagggtgtg ccattccgaa gaccatcgac ttttggcatt ccgaggctgg   2520

agaagatact cagaaacaaa gccaaaatta agttcatcat taaaaagccc gaaatgtttg   2580

agacggcgat taaggagagc acctcctcta agagccctcc cagaaaaata aattcatcac   2640

ccaatgttaa tactactgca tcaggtgttg aagaccttaa catcattcag gtgacaattc   2700

cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta agagaacaag   2760

tgaatgacct ctttagtcgg aaatttggtg aagctattgg tatgggtttt cctgtgaaag   2820

ttccctacag gaaaatcaca attaaccctg gctgtgtggt ggttgatggc atgcccccgg   2880

gggtgtcctt caaagccccc agctacctgg aaatcagctc catgagaagg atcttagact   2940

ctgccgagtt tatcaaattc acggtcatta ggtaagtgag agtttcctgc ttagtcacag   3000

gagcgaatct ggagctcatg aggctgactc ttctaaaatg cagccacagg tagtcatcga   3060

atccggcttc ctatgctgtg caatcaacaa atcaaaataa cttgtgtcat cattagaatg   3120

tcagatgtgc ttctacgaac taagctgact cttttaattc tttggcaaag ggttggcaaa   3180

ctaggactgt ttgccaaatt caggctgcct cctattttta gagtcttcct gaaacacagc   3240

tacacccgta ttatccatgg ctgctttcct gtcacagtga gtaagtagct gggactgaga   3300

aggcatggcc tccaaagtct aaaatattta ctctctagca ctttgtagaa aaaccttagc   3360

taggcacagt ggctaacgcc tgtaatccca gcattttggg aggccaaggc aggcagatca   3420

cctgaggtca ggagttccag accagcctgg ccaacatggt gaaatcccat ctctacaaaa   3480

ataaaacagt tagctgggca tgatggcggg tgcctgtaat cccagctact cgggaggctg   3540

aggcaggata gtcgcttgaa cccaggaggt ggaggttgca atgagccaag atcatgccac   3600

tgcactccag cctggacgac agagtgagac tccatcacaa gaaaaaaaga actttgtcaa   3660

cctctgtctt agggcgcctt gtcacaggct tcgggtcaga cggattcaac cttgcatcag   3720

ccatttgtta gccaggtcac tctgttcttt gtctgtaaat gagattgatc gttgttccca   3780

ctgagagtgt cagctccttc ccgtagagca ggcatgatga ttgtactcac ctctgacacc   3840

attgtgagtg ccacattcct tcccacgtcc ttgtcactgt aagagatgcc cacctgagca   3900

ccaaccccag gttatcttcc cctttgtctt ccagcccccc agaaacagct acgactcaac   3960

ctacccaatc atttcatcat cagattgcca ctgtctctag ttcaggtctc ttgggactgg   4020

cactcagaaa tctcataata aatcctcttg aggcttctca tacactcgtc ttcttccaat   4080

cttctttccc tcaaaatctc atattttggt tccacttcac ccaccgtcat tctccatatc   4140

actcccagga gttaggcaaa aagccccttc cgttcttccg tatgttaaac ttagaatcac   4200

tctgttccct gctctgcgtt tctatttttt gtttttcctc catttactag tagcttaaca   4260

ctttctaaca gtgttcttat tattgatacg tatctatctc ttccataagc ttataaggtc   4320

acggataata cttctcattg tagtacgtaa atgacgtggg ctagatatga gttgaataaa   4380

cagttatacc tgtaaattct tacagagtga aaataaattg ttatacttta caatttgttt   4440

ctctctttag accatttcca ggacttgtga ttaataaccg tgagtatttt gtgaagtgtt   4500

ttgtttttgt tttttcctgg ggtctgacgt gtgtgcgtgt gagtgtgtat acatgcttaa   4560

cgtatatcac gttacttcac ctatgtcagt aaccaggcca aatacttgtt ttagccctca   4620

gtaaaaacac caggcacttc ctagttgtaa aattattcaa gcttcttaac ttcctatcct   4680

cgatgcactt aatcataaaa tggtaataat agcaccgatt ttgggggagt cgttccagta   4740

gatggaaagc atctggaaca ggtgtcagca agctcctgcc gacgtgtatg cataaagttt   4800

tattgaaacc accatcgtgt ccatttgttt atggcagaac tgagagatgg cagcagcaag   4860

tgtgtgcctg caaaacctaa aatatttact aattggctct gcaagaaaag agtttgcatc   4920

cccctaacct agaacagtgt ctagcctcta gtatgtgttt agcctacagt atgtgctcag   4980

cgaatacaat ctatatttat tactgctttt atgactgtta taattactgt gcttggattt   5040

cgttacaaag taagtcacaa tgtgcctgct tctgttagta tttcagcaca gtgcctggca   5100

cacatggggc tctcaaatat tgctgagcga gtgaacaaat gtcctttcaa ttccttaacg   5160

ttgatgtcat tttcaatagt attttgagcc aaacttaatt ttgcgagtgt gttttgtttt   5220

cttaacttta ttattaaaaa tgtataaaag tgaggccagg cgtggtggct cacgcctgta   5280

atcccagcag tttgggaggc tgaggcaggc ggatcagttg aggttgggag ttggagacca   5340

gcccgtccaa catggtgaaa gcctgtctct actaaaaata caaaaatcag ctgggtgtgg   5400

tggcgcgtgc ctgtaatccc agctactcag gaggctgagg caggagagtt gcttgaatcc   5460

tagaggtgga ggttgcagtg agctgagatc gtgccattgc actccagcct gggcaacaag   5520

agcaaaactc tgtcccaata aataaataaa taaaatgttc tcttttgttc ctgttcttgt   5580

gcggtagtgt ggtatagagt tttatggtaa ttactgtgaa ttagtgattc tgagggacat   5640

atcagaactc tgaggtttgt ttccttctca tcttgaggga aacagcaaat gtatgttaaa   5700

atgcttttcc aagggaacaa cacatcctta cattatttaa accaatctgc ttcattttca   5760

gagctggttg atcagagtga gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc   5820

cagttggaag ttccagccac agaagaaata aaagagactg atggaagctc tcagatcaag   5880

caagaaccag accccacgtg gtagacctct tccctcctag gcttaaagta tcagtggttg   5940

agaagagctt ttcggacctg ttactacccc aagctgtgta atatacttgt ataacagaaa   6000

taccttctat acaaaccttt ttttctactt ttagatagaa atgtctactt tttcagcagt   6060

tctgtgaatt aaagagcaga gtgactgtgg gtctggaatg gctggtgtac ttgggaatgt   6120

actatcagga ttttacagca atgctgggaa atgacaggga aaatgacagg aatgaatctc   6180

accagatttt ttatgtactc agcagagcct tgagttacgg tgtttatttt ccaatcaagt   6240

gaagatatct cctacttctc ctactggaac atctcagctt ctgcagtgaa gaaaaattcc   6300

tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct   6360

ttgttcacgg ctctccttaa tgactgagtg aacagttcct atctgtatat ttgactaaac   6420

cttttcctaa gctatctctc atggttccta tgttttttta tcataattaa aagcaaaacc   6480

atctggatca cctaacagtc agaggtcagt atctcagcgt gtgaattata gaggaaatac   6540

agagagaacc tcttccactt ttacttttcg tccaaataaa atgcatggtg taccagaagt   6600

tgaagatcgg gttgaggatt ggggctagct cgatgacact aaggccccaa catcgcggga   6660

cctgctgtgg cgcggattct taggaacgct gttctagccg gccccctctc caggggtcgc   6720

cgtggccggc attatttcct agttcttctt gtaaccctga ggtgccagcg cggggagtga   6780

ggaggggtca gggggctaag gatgcaacct ctgacgttct gcgccttcct aggagagtct   6840

tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa taccagctct acaagaagct   6900

aggctctgtg acggcatagt tttcagtagc tttatcacaa tattcacaat ggagaattat   6960

atgacatggt agcagaaata ggccctttta tgtgttgctt ctattttacc tcaaattgta   7020

gatatagggt aatcaataaa atccatccat gcctttcaca cactaagt                7068


<210>  4049
<211>  857
<212>  PRT
<213>  Homo sapiens

<400>  4049

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
            500                 505                 510


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
        515                 520                 525


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
    530                 535                 540


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
545                 550                 555                 560


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
                565                 570                 575


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
            580                 585                 590


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
        595                 600                 605


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
    610                 615                 620


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
625                 630                 635                 640


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
                645                 650                 655


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
            660                 665                 670


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
        675                 680                 685


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
    690                 695                 700


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
705                 710                 715                 720


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
                725                 730                 735


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
            740                 745                 750


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
        755                 760                 765


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
    770                 775                 780


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
785                 790                 795                 800


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
                805                 810                 815


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
            820                 825                 830


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
        835                 840                 845


Glu Phe Ile Lys Phe Thr Val Ile Arg 
    850                 855


<210>  4050
<211>  4192
<212>  DNA
<213>  Homo sapiens

<400>  4050
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gtcaaagaag attggaatgt cagaattacc aagctacgga   1920

agcaagtgga agagattttt aatttgaaat ttgcttagat ttgttgacag cggtttcctg   1980

gagtgctgtc ttgagaacga ttctgaggag gctcagcaag aaagagtgtt tcagttgatt   2040

gggtgtgtct gtcatggaga aggaactcaa gctcttggac tcaccgaggc agtaaaagta   2100

ccatatcctg tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg   2160

attcccttcc gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg   2220

agtaataaaa tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct   2280

gggatggcta gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct   2340

gggagtaatt caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat   2400

cctcaaacct cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag   2460

ccacgaggga gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag   2520

aaagttgaaa atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg   2580

aaggtgccgt tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct   2640

gagggtgtgc cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc   2700

agaaacaaag ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt   2760

aaggagagca cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat   2820

actactgcat caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat   2880

aatgaaagac tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc   2940

tttagtcgga aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg   3000

aaaatcacaa ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc   3060

aaagccccca gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt   3120

atcaaattca cggtcattag accatttcca ggacttgtga ttaataacca gctggttgat   3180

cagagtgagt cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt   3240

ccagccacag aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac   3300

cccacgtggt agacctcttc cctcctagga gccttgagtt acggtgttta ttttccaatc   3360

aagtgaagat atctcctact tctcctactg gaacatctca gcttctgcag tgaagaaaaa   3420

ttcctgtgat agttcagttc tttagttttt ctatttgaaa aaaaaaaatc atttaaatga   3480

tcctttgttc acggctctcc ttaatgactg agtgaacagt tcctatctgt atatttgact   3540

aaaccttttc ctaagctatc tctcatggtt cctatgtttt tttatcataa ttaaaagcaa   3600

aaccatctgg atcacctaac agtcagaggt cagtatctca gcgtgtgaat tatagaggaa   3660

atacagagag aacctcttcc acttttactt ttcgtccaaa taaaatgcat ggtgtaccag   3720

aagttgaaga tcgggttgag gattggggct agctcgatga cactaaggcc ccaacatcgc   3780

gggacctgct gtggcgcgga ttcttaggaa cgctgttcta gccggccccc tctccagggg   3840

tcgccgtggc cggcattatt tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga   3900

gtgaggaggg gtcagggggc taaggatgca acctctgacg ttctgcgcct tcctaggaga   3960

gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt aaaataccag ctctacaaga   4020

agctaggctc tgtgacggca tagttttcag tagctttatc acaatattca caatggagaa   4080

ttatatgaca tggtagcaga aataggccct tttatgtgtt gcttctattt tacctcaaat   4140

tgtagatata gggtaatcaa taaaatccat ccatgccttt cacacactaa gt           4192


<210>  4051
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  4051

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
                485                 490                 495


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
            500                 505                 510


Phe Asn Leu Lys Phe Ala 
        515


<210>  4052
<211>  5386
<212>  DNA
<213>  Homo sapiens

<400>  4052
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2100

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2160

tttgaaattt gcttagattt gttgacagcg gtttcctgga gtgctgtctt gagaacgatt   2220

ctgaggaggc tcagcaagaa agagtgtttc agttgattgg gtgtgtctgt catggagaag   2280

gaactcaagc tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa   2340

acccggagtt cttgtatgtg gaaggcttgc cagaggggat tcccttccga agccctacct   2400

ggtttggaat tccacgactt gaaaggatcg tccgcgggag taataaaatc aagttcgttg   2460

ttaaaaaacc tgaactagtt atttcctact tgcctcctgg gatggctagt aaaataaaca   2520

ctaaagcttt gcagtccccc aaaagaccac gaagtcctgg gagtaattca aaggttcctg   2580

aaattgaggt caccgtggaa ggccctaata acaacaatcc tcaaacctca gctgttcgaa   2640

ccccgaccca gactaacggt tctaacgttc ccttcaagcc acgagggaga gagttttcct   2700

ttgaggcctg gaatgccaaa atcacggacc taaaacagaa agttgaaaat ctcttcaatg   2760

agaaatgtgg ggaagctctt ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg   2820

agtctttccc ggaagacttt tatgtggaag gcttacctga gggtgtgcca ttccgaagac   2880

catcgacttt tggcattccg aggctggaga agatactcag aaacaaagcc aaaattaagt   2940

tcatcattaa aaagcccgaa atgtttgaga cggcgattaa ggagagcacc tcctctaaga   3000

gccctcccag aaaaataaat tcatcaccca atgttaatac tactgcatca ggtgttgaag   3060

accttaacat cattcaggtg acaattccag atgatgataa tgaaagactc tcgaaagttg   3120

aaaaagctag acagctaaga gaacaagtga atgacctctt tagtcggaaa tttggtgaag   3180

ctattggtat gggttttcct gtgaaagttc cctacaggaa aatcacaatt aaccctggct   3240

gtgtggtggt tgatggcatg cccccggggg tgtccttcaa agcccccagc tacctggaaa   3300

tcagctccat gagaaggatc ttagactctg ccgagtttat caaattcacg gtcattagac   3360

catttccagg acttgtgatt aataaccagc tggttgatca gagtgagtca gaaggccccg   3420

tgatacaaga atcagctgaa ccaagccagt tggaagttcc agccacagaa gaaataaaag   3480

agactgatgg aagctctcag atcaagcaag aaccagaccc cacgtggtag acctcttccc   3540

tcctagggta aatcagcttc tgtgtcaggg atgctgtgtg gtgtccatct gaaccccctg   3600

catacgcgta gctaatgtga tctccccact ttcacataag atggtggccc tgccttcagg   3660

gaatgtggga gccaggtggg agccttcccg gatatttaag ctagaagatt ctacagggag   3720

attctccttg gatcaatata tgtctctcag tcaaagatgt aaaagcactt ttgccttaaa   3780

aagaatgttc tgtttctaaa tagagtcaac gttgtcctcc tcattggaat tcactatgag   3840

tcagaatcat tagactgact tttttttttc catagtaata gtattttgca gagtctcaca   3900

gagctgcaga tcttttgttc atcttgcaga gttaacaagt ctgatcctgt tagtccagat   3960

ttcttaaatt tggccaagtt ataataggag cagtagcttg agacccgaag tcaggaaact   4020

ttgacaatgg attttttttt ttaatccaga gacttgtact ggaatttgcc ttaccctgtc   4080

agctcatgga cttaaggttt catcccgctt tatgagtgct tctgaatcca agtcattgtt   4140

acctgaattt gcaaattaag ttgtgatatt cgtgactgtt aaattcctgt aattagatta   4200

acctctttgc ttgcttgttt gttttctctc ctattttagc ttaaagtatc agtggttgag   4260

aagagctttt cggacctgtt actaccccaa gctgtgtaat atacttgtat aacagaaata   4320

ccttctatac aaaccttttt ttctactttt agatagaaat gtctactttt tcagcagttc   4380

tgtgaattaa agagcagagt gactgtgggt ctggaatggc tggtgtactt gggaatgtac   4440

tatcaggatt ttacagcaat gctgggaaat gacagggaaa atgacaggaa tgaatctcac   4500

cagatttttt atgtactcag cagagccttg agttacggtg tttattttcc aatcaagtga   4560

agatatctcc tacttctcct actggaacat ctcagcttct gcagtgaaga aaaattcctg   4620

tgatagttca gttctttagt ttttctattt gaaaaaaaaa aatcatttaa atgatccttt   4680

gttcacggct ctccttaatg actgagtgaa cagttcctat ctgtatattt gactaaacct   4740

tttcctaagc tatctctcat ggttcctatg tttttttatc ataattaaaa gcaaaaccat   4800

ctggatcacc taacagtcag aggtcagtat ctcagcgtgt gaattataga ggaaatacag   4860

agagaacctc ttccactttt acttttcgtc caaataaaat gcatggtgta ccagaagttg   4920

aagatcgggt tgaggattgg ggctagctcg atgacactaa ggccccaaca tcgcgggacc   4980

tgctgtggcg cggattctta ggaacgctgt tctagccggc cccctctcca ggggtcgccg   5040

tggccggcat tatttcctag ttcttcttgt aaccctgagg tgccagcgcg gggagtgagg   5100

aggggtcagg gggctaagga tgcaacctct gacgttctgc gccttcctag gagagtctta   5160

catgtgttga gatttcacaa gcaatgcgag ttgtaaaata ccagctctac aagaagctag   5220

gctctgtgac ggcatagttt tcagtagctt tatcacaata ttcacaatgg agaattatat   5280

gacatggtag cagaaatagg cccttttatg tgttgcttct attttacctc aaattgtaga   5340

tatagggtaa tcaataaaat ccatccatgc ctttcacaca ctaagt                  5386


<210>  4053
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  4053

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala 
            580


<210>  4054
<211>  7237
<212>  DNA
<213>  Homo sapiens

<400>  4054
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gtcaaagaag attggaatgt cagaattacc aagctacgga   1920

agcaagtgga agagattttt aatttgaaat ttgcttagat ttgttgacag cggtttcctg   1980

gagtgctgtc ttgagaacga ttctgaggag gctcagcaag aaagagtgtt tcagttgatt   2040

gggtgtgtct gtcatggaga aggaactcaa gctcttggac tcaccgaggc agtaaaagta   2100

ccatatcctg tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg   2160

attcccttcc gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg   2220

agtaataaaa tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct   2280

gggatggcta gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct   2340

gggagtaatt caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat   2400

cctcaaacct cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag   2460

ccacgaggga gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag   2520

aaagttgaaa atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg   2580

aaggtgccgt tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct   2640

gagggtgtgc cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc   2700

agaaacaaag ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt   2760

aaggagagca cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat   2820

actactgcat caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat   2880

aatgaaagac tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc   2940

tttagtcgga aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg   3000

aaaatcacaa ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc   3060

aaagccccca gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt   3120

atcaaattca cggtcattag gtaagtgaga gtttcctgct tagtcacagg agcgaatctg   3180

gagctcatga ggctgactct tctaaaatgc agccacaggt agtcatcgaa tccggcttcc   3240

tatgctgtgc aatcaacaaa tcaaaataac ttgtgtcatc attagaatgt cagatgtgct   3300

tctacgaact aagctgactc ttttaattct ttggcaaagg gttggcaaac taggactgtt   3360

tgccaaattc aggctgcctc ctatttttag agtcttcctg aaacacagct acacccgtat   3420

tatccatggc tgctttcctg tcacagtgag taagtagctg ggactgagaa ggcatggcct   3480

ccaaagtcta aaatatttac tctctagcac tttgtagaaa aaccttagct aggcacagtg   3540

gctaacgcct gtaatcccag cattttggga ggccaaggca ggcagatcac ctgaggtcag   3600

gagttccaga ccagcctggc caacatggtg aaatcccatc tctacaaaaa taaaacagtt   3660

agctgggcat gatggcgggt gcctgtaatc ccagctactc gggaggctga ggcaggatag   3720

tcgcttgaac ccaggaggtg gaggttgcaa tgagccaaga tcatgccact gcactccagc   3780

ctggacgaca gagtgagact ccatcacaag aaaaaaagaa ctttgtcaac ctctgtctta   3840

gggcgccttg tcacaggctt cgggtcagac ggattcaacc ttgcatcagc catttgttag   3900

ccaggtcact ctgttctttg tctgtaaatg agattgatcg ttgttcccac tgagagtgtc   3960

agctccttcc cgtagagcag gcatgatgat tgtactcacc tctgacacca ttgtgagtgc   4020

cacattcctt cccacgtcct tgtcactgta agagatgccc acctgagcac caaccccagg   4080

ttatcttccc ctttgtcttc cagcccccca gaaacagcta cgactcaacc tacccaatca   4140

tttcatcatc agattgccac tgtctctagt tcaggtctct tgggactggc actcagaaat   4200

ctcataataa atcctcttga ggcttctcat acactcgtct tcttccaatc ttctttccct   4260

caaaatctca tattttggtt ccacttcacc caccgtcatt ctccatatca ctcccaggag   4320

ttaggcaaaa agccccttcc gttcttccgt atgttaaact tagaatcact ctgttccctg   4380

ctctgcgttt ctattttttg tttttcctcc atttactagt agcttaacac tttctaacag   4440

tgttcttatt attgatacgt atctatctct tccataagct tataaggtca cggataatac   4500

ttctcattgt agtacgtaaa tgacgtgggc tagatatgag ttgaataaac agttatacct   4560

gtaaattctt acagagtgaa aataaattgt tatactttac aatttgtttc tctctttaga   4620

ccatttccag gacttgtgat taataaccgt gagtattttg tgaagtgttt tgtttttgtt   4680

ttttcctggg gtctgacgtg tgtgcgtgtg agtgtgtata catgcttaac gtatatcacg   4740

ttacttcacc tatgtcagta accaggccaa atacttgttt tagccctcag taaaaacacc   4800

aggcacttcc tagttgtaaa attattcaag cttcttaact tcctatcctc gatgcactta   4860

atcataaaat ggtaataata gcaccgattt tgggggagtc gttccagtag atggaaagca   4920

tctggaacag gtgtcagcaa gctcctgccg acgtgtatgc ataaagtttt attgaaacca   4980

ccatcgtgtc catttgttta tggcagaact gagagatggc agcagcaagt gtgtgcctgc   5040

aaaacctaaa atatttacta attggctctg caagaaaaga gtttgcatcc ccctaaccta   5100

gaacagtgtc tagcctctag tatgtgttta gcctacagta tgtgctcagc gaatacaatc   5160

tatatttatt actgctttta tgactgttat aattactgtg cttggatttc gttacaaagt   5220

aagtcacaat gtgcctgctt ctgttagtat ttcagcacag tgcctggcac acatggggct   5280

ctcaaatatt gctgagcgag tgaacaaatg tcctttcaat tccttaacgt tgatgtcatt   5340

ttcaatagta ttttgagcca aacttaattt tgcgagtgtg ttttgttttc ttaactttat   5400

tattaaaaat gtataaaagt gaggccaggc gtggtggctc acgcctgtaa tcccagcagt   5460

ttgggaggct gaggcaggcg gatcagttga ggttgggagt tggagaccag cccgtccaac   5520

atggtgaaag cctgtctcta ctaaaaatac aaaaatcagc tgggtgtggt ggcgcgtgcc   5580

tgtaatccca gctactcagg aggctgaggc aggagagttg cttgaatcct agaggtggag   5640

gttgcagtga gctgagatcg tgccattgca ctccagcctg ggcaacaaga gcaaaactct   5700

gtcccaataa ataaataaat aaaatgttct cttttgttcc tgttcttgtg cggtagtgtg   5760

gtatagagtt ttatggtaat tactgtgaat tagtgattct gagggacata tcagaactct   5820

gaggtttgtt tccttctcat cttgagggaa acagcaaatg tatgttaaaa tgcttttcca   5880

agggaacaac acatccttac attatttaaa ccaatctgct tcattttcag agctggttga   5940

tcagagtgag tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt   6000

tccagccaca gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga   6060

ccccacgtgg tagacctctt ccctcctagg cttaaagtat cagtggttga gaagagcttt   6120

tcggacctgt tactacccca agctgtgtaa tatacttgta taacagaaat accttctata   6180

caaacctttt tttctacttt tagatagaaa tgtctacttt ttcagcagtt ctgtgaatta   6240

aagagcagag tgactgtggg tctggaatgg ctggtgtact tgggaatgta ctatcaggat   6300

tttacagcaa tgctgggaaa tgacagggaa aatgacagga atgaatctca ccagattttt   6360

tatgtactca gcagagcctt gagttacggt gtttattttc caatcaagtg aagatatctc   6420

ctacttctcc tactggaaca tctcagcttc tgcagtgaag aaaaattcct gtgatagttc   6480

agttctttag tttttctatt tgaaaaaaaa aaatcattta aatgatcctt tgttcacggc   6540

tctccttaat gactgagtga acagttccta tctgtatatt tgactaaacc ttttcctaag   6600

ctatctctca tggttcctat gtttttttat cataattaaa agcaaaacca tctggatcac   6660

ctaacagtca gaggtcagta tctcagcgtg tgaattatag aggaaataca gagagaacct   6720

cttccacttt tacttttcgt ccaaataaaa tgcatggtgt accagaagtt gaagatcggg   6780

ttgaggattg gggctagctc gatgacacta aggccccaac atcgcgggac ctgctgtggc   6840

gcggattctt aggaacgctg ttctagccgg ccccctctcc aggggtcgcc gtggccggca   6900

ttatttccta gttcttcttg taaccctgag gtgccagcgc ggggagtgag gaggggtcag   6960

ggggctaagg atgcaacctc tgacgttctg cgccttccta ggagagtctt acatgtgttg   7020

agatttcaca agcaatgcga gttgtaaaat accagctcta caagaagcta ggctctgtga   7080

cggcatagtt ttcagtagct ttatcacaat attcacaatg gagaattata tgacatggta   7140

gcagaaatag gcccttttat gtgttgcttc tattttacct caaattgtag atatagggta   7200

atcaataaaa tccatccatg cctttcacac actaagt                            7237


<210>  4055
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  4055

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
                485                 490                 495


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
            500                 505                 510


Phe Asn Leu Lys Phe Ala 
        515


<210>  4056
<211>  4590
<212>  DNA
<213>  Homo sapiens

<400>  4056
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   2040

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   2100

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2160

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2220

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2280

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2340

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2400

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2460

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2520

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2580

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2640

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2700

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2760

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2820

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2880

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2940

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   3000

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   3060

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3120

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3180

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3240

ttcacggtca ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt   3300

gagtcagaag gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc   3360

acagaagaaa taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg   3420

tggtagacct cttccctcct aggcttaaag tatcagtggt tgagaagagc ttttcggacc   3480

tgttactacc ccaagctgtg taatatactt gtataacaga aataccttct atacaaacct   3540

ttttttctac ttttagatag aaatgtctac tttttcagca gttctgtgaa ttaaagagca   3600

gagtgactgt gggtctggaa tggctggtgt acttgggaat gtactatcag gattttacag   3660

caatgctggg aaatgacagg gaaaatgaca ggaatgaatc tcaccagatt ttttatgtac   3720

tcagcagagc cttgagttac ggtgtttatt ttccaatcaa gtgaagatat ctcctacttc   3780

tcctactgga acatctcagc ttctgcagtg aagaaaaatt cctgtgatag ttcagttctt   3840

tagtttttct atttgaaaaa aaaaaatcat ttaaatgatc ctttgttcac ggctctcctt   3900

aatgactgag tgaacagttc ctatctgtat atttgactaa accttttcct aagctatctc   3960

tcatggttcc tatgtttttt tatcataatt aaaagcaaaa ccatctggat cacctaacag   4020

tcagaggtca gtatctcagc gtgtgaatta tagaggaaat acagagagaa cctcttccac   4080

ttttactttt cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc gggttgagga   4140

ttggggctag ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt ggcgcggatt   4200

cttaggaacg ctgttctagc cggccccctc tccaggggtc gccgtggccg gcattatttc   4260

ctagttcttc ttgtaaccct gaggtgccag cgcggggagt gaggaggggt cagggggcta   4320

aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg ttgagatttc   4380

acaagcaatg cgagttgtaa aataccagct ctacaagaag ctaggctctg tgacggcata   4440

gttttcagta gctttatcac aatattcaca atggagaatt atatgacatg gtagcagaaa   4500

taggcccttt tatgtgttgc ttctatttta cctcaaattg tagatatagg gtaatcaata   4560

aaatccatcc atgcctttca cacactaagt                                    4590


<210>  4057
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  4057

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
465                 470                 475                 480


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
                485                 490                 495


<210>  4058
<211>  7975
<212>  DNA
<213>  Homo sapiens

<400>  4058
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2040

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2100

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2160

tgaatcaaac ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag   2220

ccctacctgg tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa   2280

gttcgttgtt aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa   2340

aataaacact aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa   2400

ggttcctgaa attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc   2460

tgttcgaacc ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga   2520

gttttccttt gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct   2580

cttcaatgag aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc   2640

gttatttgag tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt   2700

ccgaagacca tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa   2760

aattaagttc atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc   2820

ctctaagagc cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg   2880

tgttgaagac cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc   2940

gaaagttgaa aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt   3000

tggtgaagct attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa   3060

ccctggctgt gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta   3120

cctggaaatc agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt   3180

cattaggtaa gtgagagttt cctgcttagt cacaggagcg aatctggagc tcatgaggct   3240

gactcttcta aaatgcagcc acaggtagtc atcgaatccg gcttcctatg ctgtgcaatc   3300

aacaaatcaa aataacttgt gtcatcatta gaatgtcaga tgtgcttcta cgaactaagc   3360

tgactctttt aattctttgg caaagggttg gcaaactagg actgtttgcc aaattcaggc   3420

tgcctcctat ttttagagtc ttcctgaaac acagctacac ccgtattatc catggctgct   3480

ttcctgtcac agtgagtaag tagctgggac tgagaaggca tggcctccaa agtctaaaat   3540

atttactctc tagcactttg tagaaaaacc ttagctaggc acagtggcta acgcctgtaa   3600

tcccagcatt ttgggaggcc aaggcaggca gatcacctga ggtcaggagt tccagaccag   3660

cctggccaac atggtgaaat cccatctcta caaaaataaa acagttagct gggcatgatg   3720

gcgggtgcct gtaatcccag ctactcggga ggctgaggca ggatagtcgc ttgaacccag   3780

gaggtggagg ttgcaatgag ccaagatcat gccactgcac tccagcctgg acgacagagt   3840

gagactccat cacaagaaaa aaagaacttt gtcaacctct gtcttagggc gccttgtcac   3900

aggcttcggg tcagacggat tcaaccttgc atcagccatt tgttagccag gtcactctgt   3960

tctttgtctg taaatgagat tgatcgttgt tcccactgag agtgtcagct ccttcccgta   4020

gagcaggcat gatgattgta ctcacctctg acaccattgt gagtgccaca ttccttccca   4080

cgtccttgtc actgtaagag atgcccacct gagcaccaac cccaggttat cttccccttt   4140

gtcttccagc cccccagaaa cagctacgac tcaacctacc caatcatttc atcatcagat   4200

tgccactgtc tctagttcag gtctcttggg actggcactc agaaatctca taataaatcc   4260

tcttgaggct tctcatacac tcgtcttctt ccaatcttct ttccctcaaa atctcatatt   4320

ttggttccac ttcacccacc gtcattctcc atatcactcc caggagttag gcaaaaagcc   4380

ccttccgttc ttccgtatgt taaacttaga atcactctgt tccctgctct gcgtttctat   4440

tttttgtttt tcctccattt actagtagct taacactttc taacagtgtt cttattattg   4500

atacgtatct atctcttcca taagcttata aggtcacgga taatacttct cattgtagta   4560

cgtaaatgac gtgggctaga tatgagttga ataaacagtt atacctgtaa attcttacag   4620

agtgaaaata aattgttata ctttacaatt tgtttctctc tttagaccat ttccaggact   4680

tgtgattaat aaccgtgagt attttgtgaa gtgttttgtt tttgtttttt cctggggtct   4740

gacgtgtgtg cgtgtgagtg tgtatacatg cttaacgtat atcacgttac ttcacctatg   4800

tcagtaacca ggccaaatac ttgttttagc cctcagtaaa aacaccaggc acttcctagt   4860

tgtaaaatta ttcaagcttc ttaacttcct atcctcgatg cacttaatca taaaatggta   4920

ataatagcac cgattttggg ggagtcgttc cagtagatgg aaagcatctg gaacaggtgt   4980

cagcaagctc ctgccgacgt gtatgcataa agttttattg aaaccaccat cgtgtccatt   5040

tgtttatggc agaactgaga gatggcagca gcaagtgtgt gcctgcaaaa cctaaaatat   5100

ttactaattg gctctgcaag aaaagagttt gcatccccct aacctagaac agtgtctagc   5160

ctctagtatg tgtttagcct acagtatgtg ctcagcgaat acaatctata tttattactg   5220

cttttatgac tgttataatt actgtgcttg gatttcgtta caaagtaagt cacaatgtgc   5280

ctgcttctgt tagtatttca gcacagtgcc tggcacacat ggggctctca aatattgctg   5340

agcgagtgaa caaatgtcct ttcaattcct taacgttgat gtcattttca atagtatttt   5400

gagccaaact taattttgcg agtgtgtttt gttttcttaa ctttattatt aaaaatgtat   5460

aaaagtgagg ccaggcgtgg tggctcacgc ctgtaatccc agcagtttgg gaggctgagg   5520

caggcggatc agttgaggtt gggagttgga gaccagcccg tccaacatgg tgaaagcctg   5580

tctctactaa aaatacaaaa atcagctggg tgtggtggcg cgtgcctgta atcccagcta   5640

ctcaggaggc tgaggcagga gagttgcttg aatcctagag gtggaggttg cagtgagctg   5700

agatcgtgcc attgcactcc agcctgggca acaagagcaa aactctgtcc caataaataa   5760

ataaataaaa tgttctcttt tgttcctgtt cttgtgcggt agtgtggtat agagttttat   5820

ggtaattact gtgaattagt gattctgagg gacatatcag aactctgagg tttgtttcct   5880

tctcatcttg agggaaacag caaatgtatg ttaaaatgct tttccaaggg aacaacacat   5940

ccttacatta tttaaaccaa tctgcttcat tttcagagct ggttgatcag agtgagtcag   6000

aaggccccgt gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag   6060

aaataaaaga gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga   6120

cctcttccct cctagggtaa atcagcttct gtgtcaggga tgctgtgtgg tgtccatctg   6180

aaccccctgc atacgcgtag ctaatgtgat ctccccactt tcacataaga tggtggccct   6240

gccttcaggg aatgtgggag ccaggtggga gccttcccgg atatttaagc tagaagattc   6300

tacagggaga ttctccttgg atcaatatat gtctctcagt caaagatgta aaagcacttt   6360

tgccttaaaa agaatgttct gtttctaaat agagtcaacg ttgtcctcct cattggaatt   6420

cactatgagt cagaatcatt agactgactt ttttttttcc atagtaatag tattttgcag   6480

agtctcacag agctgcagat cttttgttca tcttgcagag ttaacaagtc tgatcctgtt   6540

agtccagatt tcttaaattt ggccaagtta taataggagc agtagcttga gacccgaagt   6600

caggaaactt tgacaatgga tttttttttt taatccagag acttgtactg gaatttgcct   6660

taccctgtca gctcatggac ttaaggtttc atcccgcttt atgagtgctt ctgaatccaa   6720

gtcattgtta cctgaatttg caaattaagt tgtgatattc gtgactgtta aattcctgta   6780

attagattaa cctctttgct tgcttgtttg ttttctctcc tattttagct taaagtatca   6840

gtggttgaga agagcttttc ggacctgtta ctaccccaag ctgtgtaata tacttgtata   6900

acagaaatac cttctataca aacctttttt tctactttta gatagaaatg tctacttttt   6960

cagcagttct gtgaattaaa gagcagagtg actgtgggtc tggaatggct ggtgtacttg   7020

ggaatgtact atcaggattt tacagcaatg ctgggaaatg acagggaaaa tgacaggaat   7080

gaatctcacc agatttttta tgtactcagc agagccttga gttacggtgt ttattttcca   7140

atcaagtgaa gatatctcct acttctccta ctggaacatc tcagcttctg cagtgaagaa   7200

aaattcctgt gatagttcag ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa   7260

tgatcctttg ttcacggctc tccttaatga ctgagtgaac agttcctatc tgtatatttg   7320

actaaacctt ttcctaagct atctctcatg gttcctatgt ttttttatca taattaaaag   7380

caaaaccatc tggatcacct aacagtcaga ggtcagtatc tcagcgtgtg aattatagag   7440

gaaatacaga gagaacctct tccactttta cttttcgtcc aaataaaatg catggtgtac   7500

cagaagttga agatcgggtt gaggattggg gctagctcga tgacactaag gccccaacat   7560

cgcgggacct gctgtggcgc ggattcttag gaacgctgtt ctagccggcc ccctctccag   7620

gggtcgccgt ggccggcatt atttcctagt tcttcttgta accctgaggt gccagcgcgg   7680

ggagtgagga ggggtcaggg ggctaaggat gcaacctctg acgttctgcg ccttcctagg   7740

agagtcttac atgtgttgag atttcacaag caatgcgagt tgtaaaatac cagctctaca   7800

agaagctagg ctctgtgacg gcatagtttt cagtagcttt atcacaatat tcacaatgga   7860

gaattatatg acatggtagc agaaataggc ccttttatgt gttgcttcta ttttacctca   7920

aattgtagat atagggtaat caataaaatc catccatgcc tttcacacac taagt        7975


<210>  4059
<211>  922
<212>  PRT
<213>  Homo sapiens

<400>  4059

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu 
            580                 585                 590


Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg 
        595                 600                 605


Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys 
    610                 615                 620


Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys 
625                 630                 635                 640


Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly 
                645                 650                 655


Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn 
            660                 665                 670


Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn 
        675                 680                 685


Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu 
    690                 695                 700


Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu 
705                 710                 715                 720


Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys 
                725                 730                 735


Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu 
            740                 745                 750


Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile 
        755                 760                 765


Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile 
    770                 775                 780


Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser 
785                 790                 795                 800


Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr 
                805                 810                 815


Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro 
            820                 825                 830


Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu 
        835                 840                 845


Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile 
    850                 855                 860


Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn 
865                 870                 875                 880


Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys 
                885                 890                 895


Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser 
            900                 905                 910


Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
        915                 920


<210>  4060
<211>  5275
<212>  DNA
<213>  Homo sapiens

<400>  4060
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2040

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2100

tttgaaattt gcttagattt gttgacagcg gtttcctgga gtgctgtctt gagaacgatt   2160

ctgaggaggc tcagcaagaa agagtgtttc agttgattgg gtgtgtctgt catggagaag   2220

gaactcaagc tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa   2280

acccggagtt cttgtatgtg gaaggcttgc cagaggggat tcccttccga agccctacct   2340

ggtttggaat tccacgactt gaaaggatcg tccgcgggag taataaaatc aagttcgttg   2400

ttaaaaaacc tgaactagtt atttcctact tgcctcctgg gatggctagt aaaataaaca   2460

ctaaagcttt gcagtccccc aaaagaccac gaagtcctgg gagtaattca aaggttcctg   2520

aaattgaggt caccgtggaa ggccctaata acaacaatcc tcaaacctca gctgttcgaa   2580

ccccgaccca gactaacggt tctaacgttc ccttcaagcc acgagggaga gagttttcct   2640

ttgaggcctg gaatgccaaa atcacggacc taaaacagaa agttgaaaat ctcttcaatg   2700

agaaatgtgg ggaagctctt ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg   2760

agtctttccc ggaagacttt tatgtggaag gcttacctga gggtgtgcca ttccgaagac   2820

catcgacttt tggcattccg aggctggaga agatactcag aaacaaagcc aaaattaagt   2880

tcatcattaa aaagcccgaa atgtttgaga cggcgattaa ggagagcacc tcctctaaga   2940

gccctcccag aaaaataaat tcatcaccca atgttaatac tactgcatca ggtgttgaag   3000

accttaacat cattcaggtg acaattccag atgatgataa tgaaagactc tcgaaagttg   3060

aaaaagctag acagctaaga gaacaagtga atgacctctt tagtcggaaa tttggtgaag   3120

ctattggtat gggttttcct gtgaaagttc cctacaggaa aatcacaatt aaccctggct   3180

gtgtggtggt tgatggcatg cccccggggg tgtccttcaa agcccccagc tacctggaaa   3240

tcagctccat gagaaggatc ttagactctg ccgagtttat caaattcacg gtcattagac   3300

catttccagg acttgtgatt aataaccagc tggttgatca gagtgagtca gaaggccccg   3360

tgatacaaga atcagctgaa ccaagccagt tggaagttcc agccacagaa ggtaaaagga   3420

cctcttccct cctagggtaa atcagcttct gtgtcaggga tgctgtgtgg tgtccatctg   3480

aaccccctgc atacgcgtag ctaatgtgat ctccccactt tcacataaga tggtggccct   3540

gccttcaggg aatgtgggag ccaggtggga gccttcccgg atatttaagc tagaagattc   3600

tacagggaga ttctccttgg atcaatatat gtctctcagt caaagatgta aaagcacttt   3660

tgccttaaaa agaatgttct gtttctaaat agagtcaacg ttgtcctcct cattggaatt   3720

cactatgagt cagaatcatt agactgactt ttttttttcc atagtaatag tattttgcag   3780

agtctcacag agctgcagat cttttgttca tcttgcagag ttaacaagtc tgatcctgtt   3840

agtccagatt tcttaaattt ggccaagtta taataggagc agtagcttga gacccgaagt   3900

caggaaactt tgacaatgga tttttttttt taatccagag acttgtactg gaatttgcct   3960

taccctgtca gctcatggac ttaaggtttc atcccgcttt atgagtgctt ctgaatccaa   4020

gtcattgtta cctgaatttg caaattaagt tgtgatattc gtgactgtta aattcctgta   4080

attagattaa cctctttgct tgcttgtttg ttttctctcc tattttagct taaagtatca   4140

gtggttgaga agagcttttc ggacctgtta ctaccccaag ctgtgtaata tacttgtata   4200

acagaaatac cttctataca aacctttttt tctactttta gatagaaatg tctacttttt   4260

cagcagttct gtgaattaaa gagcagagtg actgtgggtc tggaatggct ggtgtacttg   4320

ggaatgtact atcaggattt tacagcaatg ctgggaaatg acagggaaaa tgacaggaat   4380

gaatctcacc agatttttta tgtactcagc agagccttga gttacggtgt ttattttcca   4440

atcaagtgaa gatatctcct acttctccta ctggaacatc tcagcttctg cagtgaagaa   4500

aaattcctgt gatagttcag ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa   4560

tgatcctttg ttcacggctc tccttaatga ctgagtgaac agttcctatc tgtatatttg   4620

actaaacctt ttcctaagct atctctcatg gttcctatgt ttttttatca taattaaaag   4680

caaaaccatc tggatcacct aacagtcaga ggtcagtatc tcagcgtgtg aattatagag   4740

gaaatacaga gagaacctct tccactttta cttttcgtcc aaataaaatg catggtgtac   4800

cagaagttga agatcgggtt gaggattggg gctagctcga tgacactaag gccccaacat   4860

cgcgggacct gctgtggcgc ggattcttag gaacgctgtt ctagccggcc ccctctccag   4920

gggtcgccgt ggccggcatt atttcctagt tcttcttgta accctgaggt gccagcgcgg   4980

ggagtgagga ggggtcaggg ggctaaggat gcaacctctg acgttctgcg ccttcctagg   5040

agagtcttac atgtgttgag atttcacaag caatgcgagt tgtaaaatac cagctctaca   5100

agaagctagg ctctgtgacg gcatagtttt cagtagcttt atcacaatat tcacaatgga   5160

gaattatatg acatggtagc agaaataggc ccttttatgt gttgcttcta ttttacctca   5220

aattgtagat atagggtaat caataaaatc catccatgcc tttcacacac taagt        5275


<210>  4061
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  4061

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala 



<210>  4062
<211>  4038
<212>  DNA
<213>  Homo sapiens

<400>  4062
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   2040

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   2100

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2160

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2220

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2280

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2340

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2400

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2460

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2520

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2580

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2640

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2700

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2760

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2820

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2880

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2940

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   3000

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   3060

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3120

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3180

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3240

ttcacggtca ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt   3300

gagtcagaag gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc   3360

acagaagaaa taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg   3420

tggtagacct cttccctcct aggcaaaacc atctggatca cctaacagtc agaggtcagt   3480

atctcagcgt gtgaattata gaggaaatac agagagaacc tcttccactt ttacttttcg   3540

tccaaataaa atgcatggtg taccagaagt tgaagatcgg gttgaggatt ggggctagct   3600

cgatgacact aaggccccaa catcgcggga cctgctgtgg cgcggattct taggaacgct   3660

gttctagccg gccccctctc caggggtcgc cgtggccggc attatttcct agttcttctt   3720

gtaaccctga ggtgccagcg cggggagtga ggaggggtca gggggctaag gatgcaacct   3780

ctgacgttct gcgccttcct aggagagtct tacatgtgtt gagatttcac aagcaatgcg   3840

agttgtaaaa taccagctct acaagaagct aggctctgtg acggcatagt tttcagtagc   3900

tttatcacaa tattcacaat ggagaattat atgacatggt agcagaaata ggccctttta   3960

tgtgttgctt ctattttacc tcaaattgta gatatagggt aatcaataaa atccatccat   4020

gcctttcaca cactaagt                                                 4038


<210>  4063
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  4063

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
465                 470                 475                 480


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
                485                 490                 495


<210>  4064
<211>  5056
<212>  DNA
<213>  Homo sapiens

<400>  4064
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gtcaaagaag attggaatgt cagaattacc aagctacgga   1920

agcaagtgga agagattttt aatttgaaat ttgctcaagc tcttggactc accgaggcag   1980

taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgtatgtg gaaggcttgc   2040

cagaggggat tcccttccga agccctacct ggtttggaat tccacgactt gaaaggatcg   2100

tccgcgggag taataaaatc aagttcgttg ttaaaaaacc tgaactagtt atttcctact   2160

tgcctcctgg gatggctagt aaaataaaca ctaaagcttt gcagtccccc aaaagaccac   2220

gaagtcctgg gagtaattca aaggttcctg aaattgaggt caccgtggaa ggccctaata   2280

acaacaatcc tcaaacctca gctgttcgaa ccccgaccca gactaacggt tctaacgttc   2340

ccttcaagcc acgagggaga gagttttcct ttgaggcctg gaatgccaaa atcacggacc   2400

taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg ggaagctctt ggccttaaac   2460

aagctgtgaa ggtgccgttc gcgttatttg agtctttccc ggaagacttt tatgtggaag   2520

gcttacctga gggtgtgcca ttccgaagac catcgacttt tggcattccg aggctggaga   2580

agatactcag aaacaaagcc aaaattaagt tcatcattaa aaagcccgaa atgtttgaga   2640

cggcgattaa ggagagcacc tcctctaaga gccctcccag aaaaataaat tcatcaccca   2700

atgttaatac tactgcatca ggtgttgaag accttaacat cattcaggtg acaattccag   2760

atgatgataa tgaaagactc tcgaaagttg aaaaagctag acagctaaga gaacaagtga   2820

atgacctctt tagtcggaaa tttggtgaag ctattggtat gggttttcct gtgaaagttc   2880

cctacaggaa aatcacaatt aaccctggct gtgtggtggt tgatggcatg cccccggggg   2940

tgtccttcaa agcccccagc tacctggaaa tcagctccat gagaaggatc ttagactctg   3000

ccgagtttat caaattcacg gtcattagac catttccagg acttgtgatt aataaccagc   3060

tggttgatca gagtgagtca gaaggccccg tgatacaaga atcagctgaa ccaagccagt   3120

tggaagttcc agccacagaa gaaataaaag agactgatgg aagctctcag atcaagcaag   3180

aaccagaccc cacgtggtag acctcttccc tcctagggta aatcagcttc tgtgtcaggg   3240

atgctgtgtg gtgtccatct gaaccccctg catacgcgta gctaatgtga tctccccact   3300

ttcacataag atggtggccc tgccttcagg gaatgtggga gccaggtggg agccttcccg   3360

gatatttaag ctagaagatt ctacagggag attctccttg gatcaatata tgtctctcag   3420

tcaaagatgt aaaagcactt ttgccttaaa aagaatgttc tgtttctaaa tagagtcaac   3480

gttgtcctcc tcattggaat tcactatgag tcagaatcat tagactgact tttttttttc   3540

catagtaata gtattttgca gagtctcaca gagctgcaga tcttttgttc atcttgcaga   3600

gttaacaagt ctgatcctgt tagtccagat ttcttaaatt tggccaagtt ataataggag   3660

cagtagcttg agacccgaag tcaggaaact ttgacaatgg attttttttt ttaatccaga   3720

gacttgtact ggaatttgcc ttaccctgtc agctcatgga cttaaggttt catcccgctt   3780

tatgagtgct tctgaatcca agtcattgtt acctgaattt gcaaattaag ttgtgatatt   3840

cgtgactgtt aaattcctgt aattagatta acctctttgc ttgcttgttt gttttctctc   3900

ctattttagc ttaaagtatc agtggttgag aagagctttt cggacctgtt actaccccaa   3960

gctgtgtaat atacttgtat aacagaaata ccttctatac aaaccttttt ttctactttt   4020

agatagaaat gtctactttt tcagcagttc tgtgaattaa agagcagagt gactgtgggt   4080

ctggaatggc tggtgtactt gggaatgtac tatcaggatt ttacagcaat gctgggaaat   4140

gacagggaaa atgacaggaa tgaatctcac cagatttttt atgtactcag cagagccttg   4200

agttacggtg tttattttcc aatcaagtga agatatctcc tacttctcct actggaacat   4260

ctcagcttct gcagtgaaga aaaattcctg tgatagttca gttctttagt ttttctattt   4320

gaaaaaaaaa aatcatttaa atgatccttt gttcacggct ctccttaatg actgagtgaa   4380

cagttcctat ctgtatattt gactaaacct tttcctaagc tatctctcat ggttcctatg   4440

tttttttatc ataattaaaa gcaaaaccat ctggatcacc taacagtcag aggtcagtat   4500

ctcagcgtgt gaattataga ggaaatacag agagaacctc ttccactttt acttttcgtc   4560

caaataaaat gcatggtgta ccagaagttg aagatcgggt tgaggattgg ggctagctcg   4620

atgacactaa ggccccaaca tcgcgggacc tgctgtggcg cggattctta ggaacgctgt   4680

tctagccggc cccctctcca ggggtcgccg tggccggcat tatttcctag ttcttcttgt   4740

aaccctgagg tgccagcgcg gggagtgagg aggggtcagg gggctaagga tgcaacctct   4800

gacgttctgc gccttcctag gagagtctta catgtgttga gatttcacaa gcaatgcgag   4860

ttgtaaaata ccagctctac aagaagctag gctctgtgac ggcatagttt tcagtagctt   4920

tatcacaata ttcacaatgg agaattatat gacatggtag cagaaatagg cccttttatg   4980

tgttgcttct attttacctc aaattgtaga tatagggtaa tcaataaaat ccatccatgc   5040

ctttcacaca ctaagt                                                   5056


<210>  4065
<211>  932
<212>  PRT
<213>  Homo sapiens

<400>  4065

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
                485                 490                 495


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
            500                 505                 510


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
        515                 520                 525


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu 
    530                 535                 540


Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile 
545                 550                 555                 560


Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val 
                565                 570                 575


Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala 
            580                 585                 590


Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser 
        595                 600                 605


Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly 
    610                 615                 620


Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln 
625                 630                 635                 640


Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser 
                645                 650                 655


Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu 
            660                 665                 670


Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala 
        675                 680                 685


Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr 
    690                 695                 700


Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe 
705                 710                 715                 720


Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys 
                725                 730                 735


Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser 
            740                 745                 750


Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val 
        755                 760                 765


Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr 
    770                 775                 780


Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg 
785                 790                 795                 800


Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu 
                805                 810                 815


Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr 
            820                 825                 830


Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser 
        835                 840                 845


Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu 
    850                 855                 860


Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly 
865                 870                 875                 880


Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro 
                885                 890                 895


Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr 
            900                 905                 910


Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro 
        915                 920                 925


Asp Pro Thr Trp 
    930


<210>  4066
<211>  4159
<212>  DNA
<213>  Homo sapiens

<400>  4066
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagctca   1980

agctcttgga ctcaccgagg cagtaaaagt accatatcct gtgtttgaat caaacccgga   2040

gttcttgtat gtggaaggct tgccagaggg gattcccttc cgaagcccta cctggtttgg   2100

aattccacga cttgaaagga tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa   2160

acctgaacta gttatttcct acttgcctcc tgggatggct agtaaaataa acactaaagc   2220

tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga   2280

ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc tcagctgttc gaaccccgac   2340

ccagactaac ggttctaacg ttcccttcaa gccacgaggg agagagtttt cctttgaggc   2400

ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa aatctcttca atgagaaatg   2460

tggggaagct cttggcctta aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt   2520

cccggaagac ttttatgtgg aaggcttacc tgagggtgtg ccattccgaa gaccatcgac   2580

ttttggcatt ccgaggctgg agaagatact cagaaacaaa gccaaaatta agttcatcat   2640

taaaaagccc gaaatgtttg agacggcgat taaggagagc acctcctcta agagccctcc   2700

cagaaaaata aattcatcac ccaatgttaa tactactgca tcaggtgttg aagaccttaa   2760

catcattcag gtgacaattc cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc   2820

tagacagcta agagaacaag tgaatgacct ctttagtcgg aaatttggtg aagctattgg   2880

tatgggtttt cctgtgaaag ttccctacag gaaaatcaca attaaccctg gctgtgtggt   2940

ggttgatggc atgcccccgg gggtgtcctt caaagccccc agctacctgg aaatcagctc   3000

catgagaagg atcttagact ctgccgagtt tatcaaattc acggtcatta gaccatttcc   3060

aggacttgtg attaataacc agctggttga tcagagtgag tcagaaggcc ccgtgataca   3120

agaatcagct gaaccaagcc agttggaagt tccagccaca gaagaaataa aagagactga   3180

tggaagctct cagatcaagc aagaaccaga ccccacgtgg tagacctctt ccctcctagg   3240

cttaaagtat cagtggttga gaagagcttt tcggacctgt tactacccca agctgtagcc   3300

ttgagttacg gtgtttattt tccaatcaag tgaagatatc tcctacttct cctactggaa   3360

catctcagct tctgcagtga agaaaaattc ctgtgatagt tcagttcttt agtttttcta   3420

tttgaaaaaa aaaaatcatt taaatgatcc tttgttcacg gctctcctta atgactgagt   3480

gaacagttcc tatctgtata tttgactaaa ccttttccta agctatctct catggttcct   3540

atgttttttt atcataatta aaagcaaaac catctggatc acctaacagt cagaggtcag   3600

tatctcagcg tgtgaattat agaggaaata cagagagaac ctcttccact tttacttttc   3660

gtccaaataa aatgcatggt gtaccagaag ttgaagatcg ggttgaggat tggggctagc   3720

tcgatgacac taaggcccca acatcgcggg acctgctgtg gcgcggattc ttaggaacgc   3780

tgttctagcc ggccccctct ccaggggtcg ccgtggccgg cattatttcc tagttcttct   3840

tgtaaccctg aggtgccagc gcggggagtg aggaggggtc agggggctaa ggatgcaacc   3900

tctgacgttc tgcgccttcc taggagagtc ttacatgtgt tgagatttca caagcaatgc   3960

gagttgtaaa ataccagctc tacaagaagc taggctctgt gacggcatag ttttcagtag   4020

ctttatcaca atattcacaa tggagaatta tatgacatgg tagcagaaat aggccctttt   4080

atgtgttgct tctattttac ctcaaattgt agatataggg taatcaataa aatccatcca   4140

tgcctttcac acactaagt                                                4159


<210>  4067
<211>  933
<212>  PRT
<213>  Homo sapiens

<400>  4067

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
        515                 520                 525


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
    530                 535                 540


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
545                 550                 555                 560


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
                565                 570                 575


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
            580                 585                 590


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
        595                 600                 605


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
    610                 615                 620


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
625                 630                 635                 640


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
                645                 650                 655


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
            660                 665                 670


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
        675                 680                 685


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
    690                 695                 700


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
705                 710                 715                 720


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
                725                 730                 735


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
            740                 745                 750


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
        755                 760                 765


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
    770                 775                 780


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
785                 790                 795                 800


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
                805                 810                 815


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
            820                 825                 830


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
        835                 840                 845


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
    850                 855                 860


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro 
865                 870                 875                 880


Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly 
                885                 890                 895


Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala 
            900                 905                 910


Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu 
        915                 920                 925


Pro Asp Pro Thr Trp 
    930


<210>  4068
<211>  4216
<212>  DNA
<213>  Homo sapiens

<400>  4068
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gtcaaagaag attggaatgt   1980

cagaattacc aagctacgga agcaagtgga agagattttt aatttgaaat ttgctcaagc   2040

tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt   2100

cttgtatgtg gaaggcttgc cagaggggat tcccttccga agccctacct ggtttggaat   2160

tccacgactt gaaaggatcg tccgcgggag taataaaatc aagttcgttg ttaaaaaacc   2220

tgaactagtt atttcctact tgcctcctgg gatggctagt aaaataaaca ctaaagcttt   2280

gcagtccccc aaaagaccac gaagtcctgg gagtaattca aaggttcctg aaattgaggt   2340

caccgtggaa ggccctaata acaacaatcc tcaaacctca gctgttcgaa ccccgaccca   2400

gactaacggt tctaacgttc ccttcaagcc acgagggaga gagttttcct ttgaggcctg   2460

gaatgccaaa atcacggacc taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg   2520

ggaagctctt ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg agtctttccc   2580

ggaagacttt tatgtggaag gcttacctga gggtgtgcca ttccgaagac catcgacttt   2640

tggcattccg aggctggaga agatactcag aaacaaagcc aaaattaagt tcatcattaa   2700

aaagcccgaa atgtttgaga cggcgattaa ggagagcacc tcctctaaga gccctcccag   2760

aaaaataaat tcatcaccca atgttaatac tactgcatca ggtgttgaag accttaacat   2820

cattcaggtg acaattccag atgatgataa tgaaagactc tcgaaagttg aaaaagctag   2880

acagctaaga gaacaagtga atgacctctt tagtcggaaa tttggtgaag ctattggtat   2940

gggttttcct gtgaaagttc cctacaggaa aatcacaatt aaccctggct gtgtggtggt   3000

tgatggcatg cccccggggg tgtccttcaa agcccccagc tacctggaaa tcagctccat   3060

gagaaggatc ttagactctg ccgagtttat caaattcacg gtcattagac catttccagg   3120

acttgtgatt aataaccagc tggttgatca gagtgagtca gaaggccccg tgatacaaga   3180

atcagctgaa ccaagccagt tggaagttcc agccacagaa gaaataaaag agactgatgg   3240

aagctctcag atcaagcaag aaccagaccc cacgtggtag acctcttccc tcctaggctt   3300

aaagtatcag tggttgagaa gagcttttcg gacctgttac taccccaagc tgtagccttg   3360

agttacggtg tttattttcc aatcaagtga agatatctcc tacttctcct actggaacat   3420

ctcagcttct gcagtgaaga aaaattcctg tgatagttca gttctttagt ttttctattt   3480

gaaaaaaaaa aatcatttaa atgatccttt gttcacggct ctccttaatg actgagtgaa   3540

cagttcctat ctgtatattt gactaaacct tttcctaagc tatctctcat ggttcctatg   3600

tttttttatc ataattaaaa gcaaaaccat ctggatcacc taacagtcag aggtcagtat   3660

ctcagcgtgt gaattataga ggaaatacag agagaacctc ttccactttt acttttcgtc   3720

caaataaaat gcatggtgta ccagaagttg aagatcgggt tgaggattgg ggctagctcg   3780

atgacactaa ggccccaaca tcgcgggacc tgctgtggcg cggattctta ggaacgctgt   3840

tctagccggc cccctctcca ggggtcgccg tggccggcat tatttcctag ttcttcttgt   3900

aaccctgagg tgccagcgcg gggagtgagg aggggtcagg gggctaagga tgcaacctct   3960

gacgttctgc gccttcctag gagagtctta catgtgttga gatttcacaa gcaatgcgag   4020

ttgtaaaata ccagctctac aagaagctag gctctgtgac ggcatagttt tcagtagctt   4080

tatcacaata ttcacaatgg agaattatat gacatggtag cagaaatagg cccttttatg   4140

tgttgcttct attttacctc aaattgtaga tatagggtaa tcaataaaat ccatccatgc   4200

ctttcacaca ctaagt                                                   4216


<210>  4069
<211>  952
<212>  PRT
<213>  Homo sapiens

<400>  4069

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr 
                565                 570                 575


Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys 
            580                 585                 590


Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro 
        595                 600                 605


Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys 
    610                 615                 620


Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val 
625                 630                 635                 640


Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg 
                645                 650                 655


Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly 
            660                 665                 670


Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys 
        675                 680                 685


Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly 
    690                 695                 700


Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro 
705                 710                 715                 720


Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg 
                725                 730                 735


Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys 
            740                 745                 750


Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala 
        755                 760                 765


Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser 
    770                 775                 780


Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile 
785                 790                 795                 800


Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val 
                805                 810                 815


Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg 
            820                 825                 830


Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr 
        835                 840                 845


Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro 
    850                 855                 860


Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met 
865                 870                 875                 880


Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
                885                 890                 895


Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu 
            900                 905                 910


Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu 
        915                 920                 925


Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile 
    930                 935                 940


Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  4070
<211>  5219
<212>  DNA
<213>  Homo sapiens

<400>  4070
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1980

aagagatttt taatttgaaa tttgcttaga tttgttgaca gcggtttcct ggagtgctgt   2040

cttgagaacg attctgagga ggctcagcaa gaaagagtgt ttcagttgat tgggtgtgtc   2100

tgtcatggag aaggaactca agctcttgga ctcaccgagg cagtaaaagt accatatcct   2160

gtgtttgaat caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc   2220

cgaagcccta cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa   2280

atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct   2340

agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat   2400

tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc   2460

tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg   2520

agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa   2580

aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg   2640

ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg   2700

ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa   2760

gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc   2820

acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca   2880

tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga   2940

ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg   3000

aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca   3060

attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt caaagccccc   3120

agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc   3180

acggtcatta gaccatttcc aggacttgtg attaataacc agctggttga tcagagtgag   3240

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   3300

gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga ccccacgtgg   3360

tagacctctt ccctcctagg gtaaatcagc ttctgtgtca gggatgctgt gtggtgtcca   3420

tctgaacccc ctgcatacgc gtagctaatg tgatctcccc actttcacat aagatggtgg   3480

ccctgccttc agggaatgtg ggagccaggt gggagccttc ccggatattt aagctagaag   3540

attctacagg gagattctcc ttggatcaat atatgtctct cagtcaaaga tgtaaaagca   3600

cttttgcctt aaaaagaatg ttctgtttct aaatagagtc aacgttgtcc tcctcattgg   3660

aattcactat gagtcagaat cattagactg actttttttt ttccatagta atagtatttt   3720

gcagagtctc acagagctgc agatcttttg ttcatcttgc agagttaaca agtctgatcc   3780

tgttagtcca gatttcttaa atttggccaa gttataatag gagcagtagc ttgagacccg   3840

aagtcaggaa actttgacaa tggatttttt tttttaatcc agagacttgt actggaattt   3900

gccttaccct gtcagctcat ggacttaagg tttcatcccg ctttatgagt gcttctgaat   3960

ccaagtcatt gttacctgaa tttgcaaatt aagttgtgat attcgtgact gttaaattcc   4020

tgtaattaga ttaacctctt tgcttgcttg tttgttttct ctcctatttt agcttaaagt   4080

atcagtggtt gagaagagct tttcggacct gttactaccc caagctgtgt aatatacttg   4140

tataacagaa ataccttcta tacaaacctt tttttctact tttagataga aatgtctact   4200

ttttcagcag ttctgtgaat taaagagcag agtgactgtg ggtctggaat ggctggtgta   4260

cttgggaatg tactatcagg attttacagc aatgctggga aatgacaggg aaaatgacag   4320

gaatgaatct caccagattt tttatgtact cagcagagcc ttgagttacg gtgtttattt   4380

tccaatcaag tgaagatatc tcctacttct cctactggaa catctcagct tctgcagtga   4440

agaaaaattc ctgtgatagt tcagttcttt agtttttcta tttgaaaaaa aaaaatcatt   4500

taaatgatcc tttgttcacg gctctcctta atgactgagt gaacagttcc tatctgtata   4560

tttgactaaa ccttttccta agctatctct catggttcct atgttttttt atcataatta   4620

aaagcaaaac catctggatc acctaacagt cagaggtcag tatctcagcg tgtgaattat   4680

agaggaaata cagagagaac ctcttccact tttacttttc gtccaaataa aatgcatggt   4740

gtaccagaag ttgaagatcg ggttgaggat tggggctagc tcgatgacac taaggcccca   4800

acatcgcggg acctgctgtg gcgcggattc ttaggaacgc tgttctagcc ggccccctct   4860

ccaggggtcg ccgtggccgg cattatttcc tagttcttct tgtaaccctg aggtgccagc   4920

gcggggagtg aggaggggtc agggggctaa ggatgcaacc tctgacgttc tgcgccttcc   4980

taggagagtc ttacatgtgt tgagatttca caagcaatgc gagttgtaaa ataccagctc   5040

tacaagaagc taggctctgt gacggcatag ttttcagtag ctttatcaca atattcacaa   5100

tggagaatta tatgacatgg tagcagaaat aggccctttt atgtgttgct tctattttac   5160

ctcaaattgt agatataggg taatcaataa aatccatcca tgcctttcac acactaagt    5219


<210>  4071
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  4071

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
    450                 455                 460


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
465                 470


<210>  4072
<211>  4134
<212>  DNA
<213>  Homo sapiens

<400>  4072
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040

taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2100

ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2160

ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2220

ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2280

ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2340

atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2400

agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2460

agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2520

tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2580

ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2640

tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2700

ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2760

atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2820

ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2880

tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   2940

ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   3000

tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3060

ttatcaaatt cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg   3120

atcagagtga gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag   3180

ttccagccac agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag   3240

accccacgtg gtagacctct tccctcctag gagccttgag ttacggtgtt tattttccaa   3300

tcaagtgaag atatctccta cttctcctac tggaacatct cagcttctgc agtgaagaaa   3360

aattcctgtg atagttcagt tctttagttt ttctatttga aaaaaaaaaa tcatttaaat   3420

gatcctttgt tcacggctct ccttaatgac tgagtgaaca gttcctatct gtatatttga   3480

ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt tttttatcat aattaaaagc   3540

aaaaccatct ggatcaccta acagtcagag gtcagtatct cagcgtgtga attatagagg   3600

aaatacagag agaacctctt ccacttttac ttttcgtcca aataaaatgc atggtgtacc   3660

agaagttgaa gatcgggttg aggattgggg ctagctcgat gacactaagg ccccaacatc   3720

gcgggacctg ctgtggcgcg gattcttagg aacgctgttc tagccggccc cctctccagg   3780

ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa ccctgaggtg ccagcgcggg   3840

gagtgaggag gggtcagggg gctaaggatg caacctctga cgttctgcgc cttcctagga   3900

gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc agctctacaa   3960

gaagctaggc tctgtgacgg catagttttc agtagcttta tcacaatatt cacaatggag   4020

aattatatga catggtagca gaaataggcc cttttatgtg ttgcttctat tttacctcaa   4080

attgtagata tagggtaatc aataaaatcc atccatgcct ttcacacact aagt         4134


<210>  4073
<211>  889
<212>  PRT
<213>  Homo sapiens

<400>  4073

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
    450                 455                 460


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
465                 470                 475                 480


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
                485                 490                 495


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
            500                 505                 510


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
        515                 520                 525


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
    530                 535                 540


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
545                 550                 555                 560


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
                565                 570                 575


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
            580                 585                 590


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
        595                 600                 605


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
    610                 615                 620


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
625                 630                 635                 640


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
                645                 650                 655


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
            660                 665                 670


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
        675                 680                 685


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
    690                 695                 700


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
705                 710                 715                 720


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
                725                 730                 735


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
            740                 745                 750


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
        755                 760                 765


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
    770                 775                 780


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
785                 790                 795                 800


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
                805                 810                 815


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
            820                 825                 830


Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser 
        835                 840                 845


Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu 
    850                 855                 860


Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln 
865                 870                 875                 880


Ile Lys Gln Glu Pro Asp Pro Thr Trp 
                885


<210>  4074
<211>  4379
<212>  DNA
<213>  Homo sapiens

<400>  4074
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1920

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   1980

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttgt   2040

atgtggaagg cttgccagag gggattccct tccgaagccc tacctggttt ggaattccac   2100

gacttgaaag gatcgtccgc gggagtaata aaatcaagtt cgttgttaaa aaacctgaac   2160

tagttatttc ctacttgcct cctgggatgg ctagtaaaat aaacactaaa gctttgcagt   2220

cccccaaaag accacgaagt cctgggagta attcaaaggt tcctgaaatt gaggtcaccg   2280

tggaaggccc taataacaac aatcctcaaa cctcagctgt tcgaaccccg acccagacta   2340

acggttctaa cgttcccttc aagccacgag ggagagagtt ttcctttgag gcctggaatg   2400

ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt caatgagaaa tgtggggaag   2460

ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt atttgagtct ttcccggaag   2520

acttttatgt ggaaggctta cctgagggtg tgccattccg aagaccatcg acttttggca   2580

ttccgaggct ggagaagata ctcagaaaca aagccaaaat taagttcatc attaaaaagc   2640

ccgaaatgtt tgagacggcg attaaggaga gcacctcctc taagagccct cccagaaaaa   2700

taaattcatc acccaatgtt aatactactg catcaggtgt tgaagacctt aacatcattc   2760

aggtgacaat tccagatgat gataatgaaa gactctcgaa agttgaaaaa gctagacagc   2820

taagagaaca agtgaatgac ctctttagtc ggaaatttgg tgaagctatt ggtatgggtt   2880

ttcctgtgaa agttccctac aggaaaatca caattaaccc tggctgtgtg gtggttgatg   2940

gcatgccccc gggggtgtcc ttcaaagccc ccagctacct ggaaatcagc tccatgagaa   3000

ggatcttaga ctctgccgag tttatcaaat tcacggtcat tagaccattt ccaggacttg   3060

tgattaataa ccagctggtt gatcagagtg agtcagaagg ccccgtgata caagaatcag   3120

ctgaaccaag ccagttggaa gttccagcca cagaagaaat aaaagagact gatggaagct   3180

ctcagatcaa gcaagaacca gaccccacgt ggtagacctc ttccctccta ggcttaaagt   3240

atcagtggtt gagaagagct tttcggacct gttactaccc caagctgtgt aatatacttg   3300

tataacagaa ataccttcta tacaaacctt tttttctact tttagataga aatgtctact   3360

ttttcagcag ttctgtgaat taaagagcag agtgactgtg ggtctggaat ggctggtgta   3420

cttgggaatg tactatcagg attttacagc aatgctggga aatgacaggg aaaatgacag   3480

gaatgaatct caccagattt tttatgtact cagcagagcc ttgagttacg gtgtttattt   3540

tccaatcaag tgaagatatc tcctacttct cctactggaa catctcagct tctgcagtga   3600

agaaaaattc ctgtgatagt tcagttcttt agtttttcta tttgaaaaaa aaaaatcatt   3660

taaatgatcc tttgttcacg gctctcctta atgactgagt gaacagttcc tatctgtata   3720

tttgactaaa ccttttccta agctatctct catggttcct atgttttttt atcataatta   3780

aaagcaaaac catctggatc acctaacagt cagaggtcag tatctcagcg tgtgaattat   3840

agaggaaata cagagagaac ctcttccact tttacttttc gtccaaataa aatgcatggt   3900

gtaccagaag ttgaagatcg ggttgaggat tggggctagc tcgatgacac taaggcccca   3960

acatcgcggg acctgctgtg gcgcggattc ttaggaacgc tgttctagcc ggccccctct   4020

ccaggggtcg ccgtggccgg cattatttcc tagttcttct tgtaaccctg aggtgccagc   4080

gcggggagtg aggaggggtc agggggctaa ggatgcaacc tctgacgttc tgcgccttcc   4140

taggagagtc ttacatgtgt tgagatttca caagcaatgc gagttgtaaa ataccagctc   4200

tacaagaagc taggctctgt gacggcatag ttttcagtag ctttatcaca atattcacaa   4260

tggagaatta tatgacatgg tagcagaaat aggccctttt atgtgttgct tctattttac   4320

ctcaaattgt agatataggg taatcaataa aatccatcca tgcctttcac acactaagt    4379


<210>  4075
<211>  937
<212>  PRT
<213>  Homo sapiens

<400>  4075

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
            500                 505                 510


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
        515                 520                 525


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
    530                 535                 540


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
545                 550                 555                 560


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
                565                 570                 575


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
            580                 585                 590


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
        595                 600                 605


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
    610                 615                 620


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
625                 630                 635                 640


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
                645                 650                 655


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
            660                 665                 670


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
        675                 680                 685


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
    690                 695                 700


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
705                 710                 715                 720


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
                725                 730                 735


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
            740                 745                 750


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
        755                 760                 765


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
    770                 775                 780


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
785                 790                 795                 800


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
                805                 810                 815


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
            820                 825                 830


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
        835                 840                 845


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
    850                 855                 860


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
865                 870                 875                 880


Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser 
                885                 890                 895


Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu 
            900                 905                 910


Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln 
        915                 920                 925


Ile Lys Gln Glu Pro Asp Pro Thr Trp 
    930                 935


<210>  4076
<211>  5064
<212>  DNA
<213>  Homo sapiens

<400>  4076
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1980

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   2040

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttga   2100

aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg aactagttat   2160

ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc agtcccccaa   2220

aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg   2280

ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga ctaacggttc   2340

taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga atgccaaaat   2400

cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg   2460

ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg aagactttta   2520

tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg gcattccgag   2580

gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa agcccgaaat   2640

gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa aaataaattc   2700

atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca ttcaggtgac   2760

aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac agctaagaga   2820

acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg gttttcctgt   2880

gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg atggcatgcc   2940

cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga gaaggatctt   3000

agactctgcc gagtttatca aattcacggt cattagacca tttccaggac ttgtgattaa   3060

taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat cagctgaacc   3120

aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa gctctcagat   3180

caagcaagaa ccagacccca cgtggtagac ctcttccctc ctagggtaaa tcagcttctg   3240

tgtcagggat gctgtgtggt gtccatctga accccctgca tacgcgtagc taatgtgatc   3300

tccccacttt cacataagat ggtggccctg ccttcaggga atgtgggagc caggtgggag   3360

ccttcccgga tatttaagct agaagattct acagggagat tctccttgga tcaatatatg   3420

tctctcagtc aaagatgtaa aagcactttt gccttaaaaa gaatgttctg tttctaaata   3480

gagtcaacgt tgtcctcctc attggaattc actatgagtc agaatcatta gactgacttt   3540

tttttttcca tagtaatagt attttgcaga gtctcacaga gctgcagatc ttttgttcat   3600

cttgcagagt taacaagtct gatcctgtta gtccagattt cttaaatttg gccaagttat   3660

aataggagca gtagcttgag acccgaagtc aggaaacttt gacaatggat tttttttttt   3720

aatccagaga cttgtactgg aatttgcctt accctgtcag ctcatggact taaggtttca   3780

tcccgcttta tgagtgcttc tgaatccaag tcattgttac ctgaatttgc aaattaagtt   3840

gtgatattcg tgactgttaa attcctgtaa ttagattaac ctctttgctt gcttgtttgt   3900

tttctctcct attttagctt aaagtatcag tggttgagaa gagcttttcg gacctgttac   3960

taccccaagc tgtgtaatat acttgtataa cagaaatacc ttctatacaa accttttttt   4020

ctacttttag atagaaatgt ctactttttc agcagttctg tgaattaaag agcagagtga   4080

ctgtgggtct ggaatggctg gtgtacttgg gaatgtacta tcaggatttt acagcaatgc   4140

tgggaaatga cagggaaaat gacaggaatg aatctcacca gattttttat gtactcagca   4200

gagccttgag ttacggtgtt tattttccaa tcaagtgaag atatctccta cttctcctac   4260

tggaacatct cagcttctgc agtgaagaaa aattcctgtg atagttcagt tctttagttt   4320

ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt tcacggctct ccttaatgac   4380

tgagtgaaca gttcctatct gtatatttga ctaaaccttt tcctaagcta tctctcatgg   4440

ttcctatgtt tttttatcat aattaaaagc aaaaccatct ggatcaccta acagtcagag   4500

gtcagtatct cagcgtgtga attatagagg aaatacagag agaacctctt ccacttttac   4560

ttttcgtcca aataaaatgc atggtgtacc agaagttgaa gatcgggttg aggattgggg   4620

ctagctcgat gacactaagg ccccaacatc gcgggacctg ctgtggcgcg gattcttagg   4680

aacgctgttc tagccggccc cctctccagg ggtcgccgtg gccggcatta tttcctagtt   4740

cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg gctaaggatg   4800

caacctctga cgttctgcgc cttcctagga gagtcttaca tgtgttgaga tttcacaagc   4860

aatgcgagtt gtaaaatacc agctctacaa gaagctaggc tctgtgacgg catagttttc   4920

agtagcttta tcacaatatt cacaatggag aattatatga catggtagca gaaataggcc   4980

cttttatgtg ttgcttctat tttacctcaa attgtagata tagggtaatc aataaaatcc   5040

atccatgcct ttcacacact aagt                                          5064


<210>  4077
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  4077

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
                565                 570                 575


Ser Ser Leu Leu Lys Asn Leu Asn 
            580


<210>  4078
<211>  7288
<212>  DNA
<213>  Homo sapiens

<400>  4078
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1980

aagagatttt taatttgaaa tttgcttaga tttgttgaca gcggtttcct ggagtgctgt   2040

cttgagaacg attctgagga ggctcagcaa gaaagagtgt ttcagttgat tgggtgtgtc   2100

tgtcatggag aaggaactca agctcttgga ctcaccgagg cagtaaaagt accatatcct   2160

gtgtttgaat caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc   2220

cgaagcccta cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa   2280

atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct   2340

agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat   2400

tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc   2460

tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg   2520

agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa   2580

aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg   2640

ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg   2700

ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa   2760

gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc   2820

acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca   2880

tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga   2940

ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg   3000

aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca   3060

attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt caaagccccc   3120

agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc   3180

acggtcatta ggtaagtgag agtttcctgc ttagtcacag gagcgaatct ggagctcatg   3240

aggctgactc ttctaaaatg cagccacagg tagtcatcga atccggcttc ctatgctgtg   3300

caatcaacaa atcaaaataa cttgtgtcat cattagaatg tcagatgtgc ttctacgaac   3360

taagctgact cttttaattc tttggcaaag ggttggcaaa ctaggactgt ttgccaaatt   3420

caggctgcct cctattttta gagtcttcct gaaacacagc tacacccgta ttatccatgg   3480

ctgctttcct gtcacagtga gtaagtagct gggactgaga aggcatggcc tccaaagtct   3540

aaaatattta ctctctagca ctttgtagaa aaaccttagc taggcacagt ggctaacgcc   3600

tgtaatccca gcattttggg aggccaaggc aggcagatca cctgaggtca ggagttccag   3660

accagcctgg ccaacatggt gaaatcccat ctctacaaaa ataaaacagt tagctgggca   3720

tgatggcggg tgcctgtaat cccagctact cgggaggctg aggcaggata gtcgcttgaa   3780

cccaggaggt ggaggttgca atgagccaag atcatgccac tgcactccag cctggacgac   3840

agagtgagac tccatcacaa gaaaaaaaga actttgtcaa cctctgtctt agggcgcctt   3900

gtcacaggct tcgggtcaga cggattcaac cttgcatcag ccatttgtta gccaggtcac   3960

tctgttcttt gtctgtaaat gagattgatc gttgttccca ctgagagtgt cagctccttc   4020

ccgtagagca ggcatgatga ttgtactcac ctctgacacc attgtgagtg ccacattcct   4080

tcccacgtcc ttgtcactgt aagagatgcc cacctgagca ccaaccccag gttatcttcc   4140

cctttgtctt ccagcccccc agaaacagct acgactcaac ctacccaatc atttcatcat   4200

cagattgcca ctgtctctag ttcaggtctc ttgggactgg cactcagaaa tctcataata   4260

aatcctcttg aggcttctca tacactcgtc ttcttccaat cttctttccc tcaaaatctc   4320

atattttggt tccacttcac ccaccgtcat tctccatatc actcccagga gttaggcaaa   4380

aagccccttc cgttcttccg tatgttaaac ttagaatcac tctgttccct gctctgcgtt   4440

tctatttttt gtttttcctc catttactag tagcttaaca ctttctaaca gtgttcttat   4500

tattgatacg tatctatctc ttccataagc ttataaggtc acggataata cttctcattg   4560

tagtacgtaa atgacgtggg ctagatatga gttgaataaa cagttatacc tgtaaattct   4620

tacagagtga aaataaattg ttatacttta caatttgttt ctctctttag accatttcca   4680

ggacttgtga ttaataaccg tgagtatttt gtgaagtgtt ttgtttttgt tttttcctgg   4740

ggtctgacgt gtgtgcgtgt gagtgtgtat acatgcttaa cgtatatcac gttacttcac   4800

ctatgtcagt aaccaggcca aatacttgtt ttagccctca gtaaaaacac caggcacttc   4860

ctagttgtaa aattattcaa gcttcttaac ttcctatcct cgatgcactt aatcataaaa   4920

tggtaataat agcaccgatt ttgggggagt cgttccagta gatggaaagc atctggaaca   4980

ggtgtcagca agctcctgcc gacgtgtatg cataaagttt tattgaaacc accatcgtgt   5040

ccatttgttt atggcagaac tgagagatgg cagcagcaag tgtgtgcctg caaaacctaa   5100

aatatttact aattggctct gcaagaaaag agtttgcatc cccctaacct agaacagtgt   5160

ctagcctcta gtatgtgttt agcctacagt atgtgctcag cgaatacaat ctatatttat   5220

tactgctttt atgactgtta taattactgt gcttggattt cgttacaaag taagtcacaa   5280

tgtgcctgct tctgttagta tttcagcaca gtgcctggca cacatggggc tctcaaatat   5340

tgctgagcga gtgaacaaat gtcctttcaa ttccttaacg ttgatgtcat tttcaatagt   5400

attttgagcc aaacttaatt ttgcgagtgt gttttgtttt cttaacttta ttattaaaaa   5460

tgtataaaag tgaggccagg cgtggtggct cacgcctgta atcccagcag tttgggaggc   5520

tgaggcaggc ggatcagttg aggttgggag ttggagacca gcccgtccaa catggtgaaa   5580

gcctgtctct actaaaaata caaaaatcag ctgggtgtgg tggcgcgtgc ctgtaatccc   5640

agctactcag gaggctgagg caggagagtt gcttgaatcc tagaggtgga ggttgcagtg   5700

agctgagatc gtgccattgc actccagcct gggcaacaag agcaaaactc tgtcccaata   5760

aataaataaa taaaatgttc tcttttgttc ctgttcttgt gcggtagtgt ggtatagagt   5820

tttatggtaa ttactgtgaa ttagtgattc tgagggacat atcagaactc tgaggtttgt   5880

ttccttctca tcttgaggga aacagcaaat gtatgttaaa atgcttttcc aagggaacaa   5940

cacatcctta cattatttaa accaatctgc ttcattttca gagctggttg atcagagtga   6000

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   6060

agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag accccacgtg   6120

gtagacctct tccctcctag gcttaaagta tcagtggttg agaagagctt ttcggacctg   6180

ttactacccc aagctgtgta atatacttgt ataacagaaa taccttctat acaaaccttt   6240

ttttctactt ttagatagaa atgtctactt tttcagcagt tctgtgaatt aaagagcaga   6300

gtgactgtgg gtctggaatg gctggtgtac ttgggaatgt actatcagga ttttacagca   6360

atgctgggaa atgacaggga aaatgacagg aatgaatctc accagatttt ttatgtactc   6420

agcagagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct cctacttctc   6480

ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta   6540

gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg ctctccttaa   6600

tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa gctatctctc   6660

atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca cctaacagtc   6720

agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc tcttccactt   6780

ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg gttgaggatt   6840

ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg cgcggattct   6900

taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc attatttcct   6960

agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca gggggctaag   7020

gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt gagatttcac   7080

aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg acggcatagt   7140

tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt agcagaaata   7200

ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt aatcaataaa   7260

atccatccat gcctttcaca cactaagt                                      7288


<210>  4079
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  4079

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
    450                 455                 460


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
465                 470


<210>  4080
<211>  4248
<212>  DNA
<213>  Homo sapiens

<400>  4080
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gtcaaagaag attggaatgt cagaattacc aagctacgga   1920

agcaagtgga agagattttt aatttgaaat ttgcttagat ttgttgacag cggtttcctg   1980

gagtgctgtc ttgagaacga ttctgaggag gctcagcaag aaagagtgtt tcagttgatt   2040

gggtgtgtct gtcatggaga aggaactcaa gctcttggac tcaccgaggc agtaaaagta   2100

ccatatcctg tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg   2160

attcccttcc gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg   2220

agtaataaaa tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct   2280

gggatggcta gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct   2340

gggagtaatt caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat   2400

cctcaaacct cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag   2460

ccacgaggga gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag   2520

aaagttgaaa atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg   2580

aaggtgccgt tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct   2640

gagggtgtgc cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc   2700

agaaacaaag ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt   2760

aaggagagca cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat   2820

actactgcat caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat   2880

aatgaaagac tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc   2940

tttagtcgga aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg   3000

aaaatcacaa ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc   3060

aaagccccca gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt   3120

atcaaattca cggtcattag accatttcca ggacttgtga ttaataacca gctggttgat   3180

cagagtgagt cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt   3240

ccagccacag aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac   3300

cccacgtggt agacctcttc cctcctaggc ttaaagtatc agtggttgag aagagctttt   3360

cggacctgtt actaccccaa gctgtagcct tgagttacgg tgtttatttt ccaatcaagt   3420

gaagatatct cctacttctc ctactggaac atctcagctt ctgcagtgaa gaaaaattcc   3480

tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct   3540

ttgttcacgg ctctccttaa tgactgagtg aacagttcct atctgtatat ttgactaaac   3600

cttttcctaa gctatctctc atggttccta tgttttttta tcataattaa aagcaaaacc   3660

atctggatca cctaacagtc agaggtcagt atctcagcgt gtgaattata gaggaaatac   3720

agagagaacc tcttccactt ttacttttcg tccaaataaa atgcatggtg taccagaagt   3780

tgaagatcgg gttgaggatt ggggctagct cgatgacact aaggccccaa catcgcggga   3840

cctgctgtgg cgcggattct taggaacgct gttctagccg gccccctctc caggggtcgc   3900

cgtggccggc attatttcct agttcttctt gtaaccctga ggtgccagcg cggggagtga   3960

ggaggggtca gggggctaag gatgcaacct ctgacgttct gcgccttcct aggagagtct   4020

tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa taccagctct acaagaagct   4080

aggctctgtg acggcatagt tttcagtagc tttatcacaa tattcacaat ggagaattat   4140

atgacatggt agcagaaata ggccctttta tgtgttgctt ctattttacc tcaaattgta   4200

gatatagggt aatcaataaa atccatccat gcctttcaca cactaagt                4248


<210>  4081
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  4081

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
                485                 490                 495


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
            500                 505                 510


Phe Asn Leu Lys Phe Ala 
        515


<210>  4082
<211>  5059
<212>  DNA
<213>  Homo sapiens

<400>  4082
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagctca agctcttgga ctcaccgagg   1980

cagtaaaagt accatatcct gtgtttgaat caaacccgga gttcttgtat gtggaaggct   2040

tgccagaggg gattcccttc cgaagcccta cctggtttgg aattccacga cttgaaagga   2100

tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa acctgaacta gttatttcct   2160

acttgcctcc tgggatggct agtaaaataa acactaaagc tttgcagtcc cccaaaagac   2220

cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta   2280

ataacaacaa tcctcaaacc tcagctgttc gaaccccgac ccagactaac ggttctaacg   2340

ttcccttcaa gccacgaggg agagagtttt cctttgaggc ctggaatgcc aaaatcacgg   2400

acctaaaaca gaaagttgaa aatctcttca atgagaaatg tggggaagct cttggcctta   2460

aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg   2520

aaggcttacc tgagggtgtg ccattccgaa gaccatcgac ttttggcatt ccgaggctgg   2580

agaagatact cagaaacaaa gccaaaatta agttcatcat taaaaagccc gaaatgtttg   2640

agacggcgat taaggagagc acctcctcta agagccctcc cagaaaaata aattcatcac   2700

ccaatgttaa tactactgca tcaggtgttg aagaccttaa catcattcag gtgacaattc   2760

cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta agagaacaag   2820

tgaatgacct ctttagtcgg aaatttggtg aagctattgg tatgggtttt cctgtgaaag   2880

ttccctacag gaaaatcaca attaaccctg gctgtgtggt ggttgatggc atgcccccgg   2940

gggtgtcctt caaagccccc agctacctgg aaatcagctc catgagaagg atcttagact   3000

ctgccgagtt tatcaaattc acggtcatta gaccatttcc aggacttgtg attaataacc   3060

agctggttga tcagagtgag tcagaaggcc ccgtgataca agaatcagct gaaccaagcc   3120

agttggaagt tccagccaca gaagaaataa aagagactga tggaagctct cagatcaagc   3180

aagaaccaga ccccacgtgg tagacctctt ccctcctagg gtaaatcagc ttctgtgtca   3240

gggatgctgt gtggtgtcca tctgaacccc ctgcatacgc gtagctaatg tgatctcccc   3300

actttcacat aagatggtgg ccctgccttc agggaatgtg ggagccaggt gggagccttc   3360

ccggatattt aagctagaag attctacagg gagattctcc ttggatcaat atatgtctct   3420

cagtcaaaga tgtaaaagca cttttgcctt aaaaagaatg ttctgtttct aaatagagtc   3480

aacgttgtcc tcctcattgg aattcactat gagtcagaat cattagactg actttttttt   3540

ttccatagta atagtatttt gcagagtctc acagagctgc agatcttttg ttcatcttgc   3600

agagttaaca agtctgatcc tgttagtcca gatttcttaa atttggccaa gttataatag   3660

gagcagtagc ttgagacccg aagtcaggaa actttgacaa tggatttttt tttttaatcc   3720

agagacttgt actggaattt gccttaccct gtcagctcat ggacttaagg tttcatcccg   3780

ctttatgagt gcttctgaat ccaagtcatt gttacctgaa tttgcaaatt aagttgtgat   3840

attcgtgact gttaaattcc tgtaattaga ttaacctctt tgcttgcttg tttgttttct   3900

ctcctatttt agcttaaagt atcagtggtt gagaagagct tttcggacct gttactaccc   3960

caagctgtgt aatatacttg tataacagaa ataccttcta tacaaacctt tttttctact   4020

tttagataga aatgtctact ttttcagcag ttctgtgaat taaagagcag agtgactgtg   4080

ggtctggaat ggctggtgta cttgggaatg tactatcagg attttacagc aatgctggga   4140

aatgacaggg aaaatgacag gaatgaatct caccagattt tttatgtact cagcagagcc   4200

ttgagttacg gtgtttattt tccaatcaag tgaagatatc tcctacttct cctactggaa   4260

catctcagct tctgcagtga agaaaaattc ctgtgatagt tcagttcttt agtttttcta   4320

tttgaaaaaa aaaaatcatt taaatgatcc tttgttcacg gctctcctta atgactgagt   4380

gaacagttcc tatctgtata tttgactaaa ccttttccta agctatctct catggttcct   4440

atgttttttt atcataatta aaagcaaaac catctggatc acctaacagt cagaggtcag   4500

tatctcagcg tgtgaattat agaggaaata cagagagaac ctcttccact tttacttttc   4560

gtccaaataa aatgcatggt gtaccagaag ttgaagatcg ggttgaggat tggggctagc   4620

tcgatgacac taaggcccca acatcgcggg acctgctgtg gcgcggattc ttaggaacgc   4680

tgttctagcc ggccccctct ccaggggtcg ccgtggccgg cattatttcc tagttcttct   4740

tgtaaccctg aggtgccagc gcggggagtg aggaggggtc agggggctaa ggatgcaacc   4800

tctgacgttc tgcgccttcc taggagagtc ttacatgtgt tgagatttca caagcaatgc   4860

gagttgtaaa ataccagctc tacaagaagc taggctctgt gacggcatag ttttcagtag   4920

ctttatcaca atattcacaa tggagaatta tatgacatgg tagcagaaat aggccctttt   4980

atgtgttgct tctattttac ctcaaattgt agatataggg taatcaataa aatccatcca   5040

tgcctttcac acactaagt                                                5059


<210>  4083
<211>  933
<212>  PRT
<213>  Homo sapiens

<400>  4083

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
        515                 520                 525


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
    530                 535                 540


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
545                 550                 555                 560


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
                565                 570                 575


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
            580                 585                 590


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
        595                 600                 605


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
    610                 615                 620


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
625                 630                 635                 640


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
                645                 650                 655


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
            660                 665                 670


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
        675                 680                 685


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
    690                 695                 700


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
705                 710                 715                 720


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
                725                 730                 735


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
            740                 745                 750


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
        755                 760                 765


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
    770                 775                 780


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
785                 790                 795                 800


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
                805                 810                 815


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
            820                 825                 830


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
        835                 840                 845


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
    850                 855                 860


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro 
865                 870                 875                 880


Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly 
                885                 890                 895


Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala 
            900                 905                 910


Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu 
        915                 920                 925


Pro Asp Pro Thr Trp 
    930


<210>  4084
<211>  3818
<212>  DNA
<213>  Homo sapiens

<400>  4084
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagc tcaagctctt ggactcaccg   1980

aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag   2040

gcttgccaga ggggattccc ttccgaagcc ctacctggtt tggaattcca cgacttgaaa   2100

ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt   2160

cctacttgcc tcctgggatg gctagtaaaa taaacactaa agctttgcag tcccccaaaa   2220

gaccacgaag tcctgggagt aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc   2280

ctaataacaa caatcctcaa acctcagctg ttcgaacccc gacccagact aacggttcta   2340

acgttccctt caagccacga gggagagagt tttcctttga ggcctggaat gccaaaatca   2400

cggacctaaa acagaaagtt gaaaatctct tcaatgagaa atgtggggaa gctcttggcc   2460

ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc tttcccggaa gacttttatg   2520

tggaaggctt acctgagggt gtgccattcc gaagaccatc gacttttggc attccgaggc   2580

tggagaagat actcagaaac aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt   2640

ttgagacggc gattaaggag agcacctcct ctaagagccc tcccagaaaa ataaattcat   2700

cacccaatgt taatactact gcatcaggtg ttgaagacct taacatcatt caggtgacaa   2760

ttccagatga tgataatgaa agactctcga aagttgaaaa agctagacag ctaagagaac   2820

aagtgaatga cctctttagt cggaaatttg gtgaagctat tggtatgggt tttcctgtga   2880

aagttcccta caggaaaatc acaattaacc ctggctgtgt ggtggttgat ggcatgcccc   2940

cgggggtgtc cttcaaagcc cccagctacc tggaaatcag ctccatgaga aggatcttag   3000

actctgccga gtttatcaaa ttcacggtca ttagaccatt tccaggactt gtgattaata   3060

accagctggt tgatcagagt gagtcagaag gccccgtgat acaagaatca gctgaaccaa   3120

gccagttgga agttccagcc acagaagaaa taaaagagac tgatggaagc tctcagatca   3180

agcaagaacc agaccccacg tggtagacct cttccctcct aggcaaaacc atctggatca   3240

cctaacagtc agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc   3300

tcttccactt ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg   3360

gttgaggatt ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg   3420

cgcggattct taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc   3480

attatttcct agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca   3540

gggggctaag gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt   3600

gagatttcac aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg   3660

acggcatagt tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt   3720

agcagaaata ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt   3780

aatcaataaa atccatccat gcctttcaca cactaagt                           3818


<210>  4085
<211>  934
<212>  PRT
<213>  Homo sapiens

<400>  4085

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala 
        515                 520                 525


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr 
    530                 535                 540


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe 
545                 550                 555                 560


Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys 
                565                 570                 575


Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly 
            580                 585                 590


Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro 
        595                 600                 605


Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val 
    610                 615                 620


Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro 
625                 630                 635                 640


Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu 
                645                 650                 655


Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys 
            660                 665                 670


Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys 
        675                 680                 685


Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp 
    690                 695                 700


Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser 
705                 710                 715                 720


Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys 
                725                 730                 735


Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys 
            740                 745                 750


Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro 
        755                 760                 765


Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln 
    770                 775                 780


Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys 
785                 790                 795                 800


Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe 
                805                 810                 815


Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys 
            820                 825                 830


Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly 
        835                 840                 845


Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg 
    850                 855                 860


Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe 
865                 870                 875                 880


Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu 
                885                 890                 895


Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro 
            900                 905                 910


Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln 
        915                 920                 925


Glu Pro Asp Pro Thr Trp 
    930


<210>  4086
<211>  7900
<212>  DNA
<213>  Homo sapiens

<400>  4086
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagctca   2040

agctcttgga ctcaccgagg cagtaaaagt accatatcct gtgtttgaat caaacccgga   2100

gttcttgtat gtggaaggct tgccagaggg gattcccttc cgaagcccta cctggtttgg   2160

aattccacga cttgaaagga tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa   2220

acctgaacta gttatttcct acttgcctcc tgggatggct agtaaaataa acactaaagc   2280

tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga   2340

ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc tcagctgttc gaaccccgac   2400

ccagactaac ggttctaacg ttcccttcaa gccacgaggg agagagtttt cctttgaggc   2460

ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa aatctcttca atgagaaatg   2520

tggggaagct cttggcctta aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt   2580

cccggaagac ttttatgtgg aaggcttacc tgagggtgtg ccattccgaa gaccatcgac   2640

ttttggcatt ccgaggctgg agaagatact cagaaacaaa gccaaaatta agttcatcat   2700

taaaaagccc gaaatgtttg agacggcgat taaggagagc acctcctcta agagccctcc   2760

cagaaaaata aattcatcac ccaatgttaa tactactgca tcaggtgttg aagaccttaa   2820

catcattcag gtgacaattc cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc   2880

tagacagcta agagaacaag tgaatgacct ctttagtcgg aaatttggtg aagctattgg   2940

tatgggtttt cctgtgaaag ttccctacag gaaaatcaca attaaccctg gctgtgtggt   3000

ggttgatggc atgcccccgg gggtgtcctt caaagccccc agctacctgg aaatcagctc   3060

catgagaagg atcttagact ctgccgagtt tatcaaattc acggtcatta ggtaagtgag   3120

agtttcctgc ttagtcacag gagcgaatct ggagctcatg aggctgactc ttctaaaatg   3180

cagccacagg tagtcatcga atccggcttc ctatgctgtg caatcaacaa atcaaaataa   3240

cttgtgtcat cattagaatg tcagatgtgc ttctacgaac taagctgact cttttaattc   3300

tttggcaaag ggttggcaaa ctaggactgt ttgccaaatt caggctgcct cctattttta   3360

gagtcttcct gaaacacagc tacacccgta ttatccatgg ctgctttcct gtcacagtga   3420

gtaagtagct gggactgaga aggcatggcc tccaaagtct aaaatattta ctctctagca   3480

ctttgtagaa aaaccttagc taggcacagt ggctaacgcc tgtaatccca gcattttggg   3540

aggccaaggc aggcagatca cctgaggtca ggagttccag accagcctgg ccaacatggt   3600

gaaatcccat ctctacaaaa ataaaacagt tagctgggca tgatggcggg tgcctgtaat   3660

cccagctact cgggaggctg aggcaggata gtcgcttgaa cccaggaggt ggaggttgca   3720

atgagccaag atcatgccac tgcactccag cctggacgac agagtgagac tccatcacaa   3780

gaaaaaaaga actttgtcaa cctctgtctt agggcgcctt gtcacaggct tcgggtcaga   3840

cggattcaac cttgcatcag ccatttgtta gccaggtcac tctgttcttt gtctgtaaat   3900

gagattgatc gttgttccca ctgagagtgt cagctccttc ccgtagagca ggcatgatga   3960

ttgtactcac ctctgacacc attgtgagtg ccacattcct tcccacgtcc ttgtcactgt   4020

aagagatgcc cacctgagca ccaaccccag gttatcttcc cctttgtctt ccagcccccc   4080

agaaacagct acgactcaac ctacccaatc atttcatcat cagattgcca ctgtctctag   4140

ttcaggtctc ttgggactgg cactcagaaa tctcataata aatcctcttg aggcttctca   4200

tacactcgtc ttcttccaat cttctttccc tcaaaatctc atattttggt tccacttcac   4260

ccaccgtcat tctccatatc actcccagga gttaggcaaa aagccccttc cgttcttccg   4320

tatgttaaac ttagaatcac tctgttccct gctctgcgtt tctatttttt gtttttcctc   4380

catttactag tagcttaaca ctttctaaca gtgttcttat tattgatacg tatctatctc   4440

ttccataagc ttataaggtc acggataata cttctcattg tagtacgtaa atgacgtggg   4500

ctagatatga gttgaataaa cagttatacc tgtaaattct tacagagtga aaataaattg   4560

ttatacttta caatttgttt ctctctttag accatttcca ggacttgtga ttaataaccg   4620

tgagtatttt gtgaagtgtt ttgtttttgt tttttcctgg ggtctgacgt gtgtgcgtgt   4680

gagtgtgtat acatgcttaa cgtatatcac gttacttcac ctatgtcagt aaccaggcca   4740

aatacttgtt ttagccctca gtaaaaacac caggcacttc ctagttgtaa aattattcaa   4800

gcttcttaac ttcctatcct cgatgcactt aatcataaaa tggtaataat agcaccgatt   4860

ttgggggagt cgttccagta gatggaaagc atctggaaca ggtgtcagca agctcctgcc   4920

gacgtgtatg cataaagttt tattgaaacc accatcgtgt ccatttgttt atggcagaac   4980

tgagagatgg cagcagcaag tgtgtgcctg caaaacctaa aatatttact aattggctct   5040

gcaagaaaag agtttgcatc cccctaacct agaacagtgt ctagcctcta gtatgtgttt   5100

agcctacagt atgtgctcag cgaatacaat ctatatttat tactgctttt atgactgtta   5160

taattactgt gcttggattt cgttacaaag taagtcacaa tgtgcctgct tctgttagta   5220

tttcagcaca gtgcctggca cacatggggc tctcaaatat tgctgagcga gtgaacaaat   5280

gtcctttcaa ttccttaacg ttgatgtcat tttcaatagt attttgagcc aaacttaatt   5340

ttgcgagtgt gttttgtttt cttaacttta ttattaaaaa tgtataaaag tgaggccagg   5400

cgtggtggct cacgcctgta atcccagcag tttgggaggc tgaggcaggc ggatcagttg   5460

aggttgggag ttggagacca gcccgtccaa catggtgaaa gcctgtctct actaaaaata   5520

caaaaatcag ctgggtgtgg tggcgcgtgc ctgtaatccc agctactcag gaggctgagg   5580

caggagagtt gcttgaatcc tagaggtgga ggttgcagtg agctgagatc gtgccattgc   5640

actccagcct gggcaacaag agcaaaactc tgtcccaata aataaataaa taaaatgttc   5700

tcttttgttc ctgttcttgt gcggtagtgt ggtatagagt tttatggtaa ttactgtgaa   5760

ttagtgattc tgagggacat atcagaactc tgaggtttgt ttccttctca tcttgaggga   5820

aacagcaaat gtatgttaaa atgcttttcc aagggaacaa cacatcctta cattatttaa   5880

accaatctgc ttcattttca gagctggttg atcagagtga gtcagaaggc cccgtgatac   5940

aagaatcagc tgaaccaagc cagttggaag ttccagccac agaagaaata aaagagactg   6000

atggaagctc tcagatcaag caagaaccag accccacgtg gtagacctct tccctcctag   6060

ggtaaatcag cttctgtgtc agggatgctg tgtggtgtcc atctgaaccc cctgcatacg   6120

cgtagctaat gtgatctccc cactttcaca taagatggtg gccctgcctt cagggaatgt   6180

gggagccagg tgggagcctt cccggatatt taagctagaa gattctacag ggagattctc   6240

cttggatcaa tatatgtctc tcagtcaaag atgtaaaagc acttttgcct taaaaagaat   6300

gttctgtttc taaatagagt caacgttgtc ctcctcattg gaattcacta tgagtcagaa   6360

tcattagact gacttttttt tttccatagt aatagtattt tgcagagtct cacagagctg   6420

cagatctttt gttcatcttg cagagttaac aagtctgatc ctgttagtcc agatttctta   6480

aatttggcca agttataata ggagcagtag cttgagaccc gaagtcagga aactttgaca   6540

atggattttt ttttttaatc cagagacttg tactggaatt tgccttaccc tgtcagctca   6600

tggacttaag gtttcatccc gctttatgag tgcttctgaa tccaagtcat tgttacctga   6660

atttgcaaat taagttgtga tattcgtgac tgttaaattc ctgtaattag attaacctct   6720

ttgcttgctt gtttgttttc tctcctattt tagcttaaag tatcagtggt tgagaagagc   6780

ttttcggacc tgttactacc ccaagctgtg taatatactt gtataacaga aataccttct   6840

atacaaacct ttttttctac ttttagatag aaatgtctac tttttcagca gttctgtgaa   6900

ttaaagagca gagtgactgt gggtctggaa tggctggtgt acttgggaat gtactatcag   6960

gattttacag caatgctggg aaatgacagg gaaaatgaca ggaatgaatc tcaccagatt   7020

ttttatgtac tcagcagagc cttgagttac ggtgtttatt ttccaatcaa gtgaagatat   7080

ctcctacttc tcctactgga acatctcagc ttctgcagtg aagaaaaatt cctgtgatag   7140

ttcagttctt tagtttttct atttgaaaaa aaaaaatcat ttaaatgatc ctttgttcac   7200

ggctctcctt aatgactgag tgaacagttc ctatctgtat atttgactaa accttttcct   7260

aagctatctc tcatggttcc tatgtttttt tatcataatt aaaagcaaaa ccatctggat   7320

cacctaacag tcagaggtca gtatctcagc gtgtgaatta tagaggaaat acagagagaa   7380

cctcttccac ttttactttt cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc   7440

gggttgagga ttggggctag ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt   7500

ggcgcggatt cttaggaacg ctgttctagc cggccccctc tccaggggtc gccgtggccg   7560

gcattatttc ctagttcttc ttgtaaccct gaggtgccag cgcggggagt gaggaggggt   7620

cagggggcta aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg   7680

ttgagatttc acaagcaatg cgagttgtaa aataccagct ctacaagaag ctaggctctg   7740

tgacggcata gttttcagta gctttatcac aatattcaca atggagaatt atatgacatg   7800

gtagcagaaa taggcccttt tatgtgttgc ttctatttta cctcaaattg tagatatagg   7860

gtaatcaata aaatccatcc atgcctttca cacactaagt                         7900


<210>  4087
<211>  897
<212>  PRT
<213>  Homo sapiens

<400>  4087

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu 
    530                 535                 540


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
545                 550                 555                 560


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
                565                 570                 575


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
            580                 585                 590


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
        595                 600                 605


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
    610                 615                 620


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
625                 630                 635                 640


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
                645                 650                 655


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
            660                 665                 670


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
        675                 680                 685


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
    690                 695                 700


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
705                 710                 715                 720


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
                725                 730                 735


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
            740                 745                 750


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
        755                 760                 765


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
    770                 775                 780


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
785                 790                 795                 800


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
                805                 810                 815


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
            820                 825                 830


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
        835                 840                 845


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
    850                 855                 860


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
865                 870                 875                 880


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
                885                 890                 895


Arg 



<210>  4088
<211>  4999
<212>  DNA
<213>  Homo sapiens

<400>  4088
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagctca agctcttgga ctcaccgagg   1920

cagtaaaagt accatatcct gtgtttgaat caaacccgga gttcttgtat gtggaaggct   1980

tgccagaggg gattcccttc cgaagcccta cctggtttgg aattccacga cttgaaagga   2040

tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa acctgaacta gttatttcct   2100

acttgcctcc tgggatggct agtaaaataa acactaaagc tttgcagtcc cccaaaagac   2160

cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta   2220

ataacaacaa tcctcaaacc tcagctgttc gaaccccgac ccagactaac ggttctaacg   2280

ttcccttcaa gccacgaggg agagagtttt cctttgaggc ctggaatgcc aaaatcacgg   2340

acctaaaaca gaaagttgaa aatctcttca atgagaaatg tggggaagct cttggcctta   2400

aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg   2460

aaggcttacc tgagggtgtg ccattccgaa gaccatcgac ttttggcatt ccgaggctgg   2520

agaagatact cagaaacaaa gccaaaatta agttcatcat taaaaagccc gaaatgtttg   2580

agacggcgat taaggagagc acctcctcta agagccctcc cagaaaaata aattcatcac   2640

ccaatgttaa tactactgca tcaggtgttg aagaccttaa catcattcag gtgacaattc   2700

cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta agagaacaag   2760

tgaatgacct ctttagtcgg aaatttggtg aagctattgg tatgggtttt cctgtgaaag   2820

ttccctacag gaaaatcaca attaaccctg gctgtgtggt ggttgatggc atgcccccgg   2880

gggtgtcctt caaagccccc agctacctgg aaatcagctc catgagaagg atcttagact   2940

ctgccgagtt tatcaaattc acggtcatta gaccatttcc aggacttgtg attaataacc   3000

agctggttga tcagagtgag tcagaaggcc ccgtgataca agaatcagct gaaccaagcc   3060

agttggaagt tccagccaca gaagaaataa aagagactga tggaagctct cagatcaagc   3120

aagaaccaga ccccacgtgg tagacctctt ccctcctagg gtaaatcagc ttctgtgtca   3180

gggatgctgt gtggtgtcca tctgaacccc ctgcatacgc gtagctaatg tgatctcccc   3240

actttcacat aagatggtgg ccctgccttc agggaatgtg ggagccaggt gggagccttc   3300

ccggatattt aagctagaag attctacagg gagattctcc ttggatcaat atatgtctct   3360

cagtcaaaga tgtaaaagca cttttgcctt aaaaagaatg ttctgtttct aaatagagtc   3420

aacgttgtcc tcctcattgg aattcactat gagtcagaat cattagactg actttttttt   3480

ttccatagta atagtatttt gcagagtctc acagagctgc agatcttttg ttcatcttgc   3540

agagttaaca agtctgatcc tgttagtcca gatttcttaa atttggccaa gttataatag   3600

gagcagtagc ttgagacccg aagtcaggaa actttgacaa tggatttttt tttttaatcc   3660

agagacttgt actggaattt gccttaccct gtcagctcat ggacttaagg tttcatcccg   3720

ctttatgagt gcttctgaat ccaagtcatt gttacctgaa tttgcaaatt aagttgtgat   3780

attcgtgact gttaaattcc tgtaattaga ttaacctctt tgcttgcttg tttgttttct   3840

ctcctatttt agcttaaagt atcagtggtt gagaagagct tttcggacct gttactaccc   3900

caagctgtgt aatatacttg tataacagaa ataccttcta tacaaacctt tttttctact   3960

tttagataga aatgtctact ttttcagcag ttctgtgaat taaagagcag agtgactgtg   4020

ggtctggaat ggctggtgta cttgggaatg tactatcagg attttacagc aatgctggga   4080

aatgacaggg aaaatgacag gaatgaatct caccagattt tttatgtact cagcagagcc   4140

ttgagttacg gtgtttattt tccaatcaag tgaagatatc tcctacttct cctactggaa   4200

catctcagct tctgcagtga agaaaaattc ctgtgatagt tcagttcttt agtttttcta   4260

tttgaaaaaa aaaaatcatt taaatgatcc tttgttcacg gctctcctta atgactgagt   4320

gaacagttcc tatctgtata tttgactaaa ccttttccta agctatctct catggttcct   4380

atgttttttt atcataatta aaagcaaaac catctggatc acctaacagt cagaggtcag   4440

tatctcagcg tgtgaattat agaggaaata cagagagaac ctcttccact tttacttttc   4500

gtccaaataa aatgcatggt gtaccagaag ttgaagatcg ggttgaggat tggggctagc   4560

tcgatgacac taaggcccca acatcgcggg acctgctgtg gcgcggattc ttaggaacgc   4620

tgttctagcc ggccccctct ccaggggtcg ccgtggccgg cattatttcc tagttcttct   4680

tgtaaccctg aggtgccagc gcggggagtg aggaggggtc agggggctaa ggatgcaacc   4740

tctgacgttc tgcgccttcc taggagagtc ttacatgtgt tgagatttca caagcaatgc   4800

gagttgtaaa ataccagctc tacaagaagc taggctctgt gacggcatag ttttcagtag   4860

ctttatcaca atattcacaa tggagaatta tatgacatgg tagcagaaat aggccctttt   4920

atgtgttgct tctattttac ctcaaattgt agatataggg taatcaataa aatccatcca   4980

tgcctttcac acactaagt                                                4999


<210>  4089
<211>  913
<212>  PRT
<213>  Homo sapiens

<400>  4089

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
            500                 505                 510


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
        515                 520                 525


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
    530                 535                 540


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
545                 550                 555                 560


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
                565                 570                 575


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
            580                 585                 590


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
        595                 600                 605


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
    610                 615                 620


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
625                 630                 635                 640


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
                645                 650                 655


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
            660                 665                 670


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
        675                 680                 685


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
    690                 695                 700


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
705                 710                 715                 720


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
                725                 730                 735


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
            740                 745                 750


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
        755                 760                 765


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
    770                 775                 780


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
785                 790                 795                 800


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
                805                 810                 815


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
            820                 825                 830


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
        835                 840                 845


Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile 
    850                 855                 860


Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln 
865                 870                 875                 880


Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile 
                885                 890                 895


Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr 
            900                 905                 910


Trp 



<210>  4090
<211>  4350
<212>  DNA
<213>  Homo sapiens

<400>  4090
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2040

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2100

tttgaaattt gcttagattt gttgacagcg gtttcctgga gtgctgtctt gagaacgatt   2160

ctgaggaggc tcagcaagaa agagtgtttc agttgattgg gtgtgtctgt catggagaag   2220

gaactcaagc tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa   2280

acccggagtt cttgtatgtg gaaggcttgc cagaggggat tcccttccga agccctacct   2340

ggtttggaat tccacgactt gaaaggatcg tccgcgggag taataaaatc aagttcgttg   2400

ttaaaaaacc tgaactagtt atttcctact tgcctcctgg gatggctagt aaaataaaca   2460

ctaaagcttt gcagtccccc aaaagaccac gaagtcctgg gagtaattca aaggttcctg   2520

aaattgaggt caccgtggaa ggccctaata acaacaatcc tcaaacctca gctgttcgaa   2580

ccccgaccca gactaacggt tctaacgttc ccttcaagcc acgagggaga gagttttcct   2640

ttgaggcctg gaatgccaaa atcacggacc taaaacagaa agttgaaaat ctcttcaatg   2700

agaaatgtgg ggaagctctt ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg   2760

agtctttccc ggaagacttt tatgtggaag gcttacctga gggtgtgcca ttccgaagac   2820

catcgacttt tggcattccg aggctggaga agatactcag aaacaaagcc aaaattaagt   2880

tcatcattaa aaagcccgaa atgtttgaga cggcgattaa ggagagcacc tcctctaaga   2940

gccctcccag aaaaataaat tcatcaccca atgttaatac tactgcatca ggtgttgaag   3000

accttaacat cattcaggtg acaattccag atgatgataa tgaaagactc tcgaaagttg   3060

aaaaagctag acagctaaga gaacaagtga atgacctctt tagtcggaaa tttggtgaag   3120

ctattggtat gggttttcct gtgaaagttc cctacaggaa aatcacaatt aaccctggct   3180

gtgtggtggt tgatggcatg cccccggggg tgtccttcaa agcccccagc tacctggaaa   3240

tcagctccat gagaaggatc ttagactctg ccgagtttat caaattcacg gtcattagac   3300

catttccagg acttgtgatt aataaccagc tggttgatca gagtgagtca gaaggccccg   3360

tgatacaaga atcagctgaa ccaagccagt tggaagttcc agccacagaa gaaataaaag   3420

agactgatgg aagctctcag atcaagcaag aaccagaccc cacgtggtag acctcttccc   3480

tcctaggagc cttgagttac ggtgtttatt ttccaatcaa gtgaagatat ctcctacttc   3540

tcctactgga acatctcagc ttctgcagtg aagaaaaatt cctgtgatag ttcagttctt   3600

tagtttttct atttgaaaaa aaaaaatcat ttaaatgatc ctttgttcac ggctctcctt   3660

aatgactgag tgaacagttc ctatctgtat atttgactaa accttttcct aagctatctc   3720

tcatggttcc tatgtttttt tatcataatt aaaagcaaaa ccatctggat cacctaacag   3780

tcagaggtca gtatctcagc gtgtgaatta tagaggaaat acagagagaa cctcttccac   3840

ttttactttt cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc gggttgagga   3900

ttggggctag ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt ggcgcggatt   3960

cttaggaacg ctgttctagc cggccccctc tccaggggtc gccgtggccg gcattatttc   4020

ctagttcttc ttgtaaccct gaggtgccag cgcggggagt gaggaggggt cagggggcta   4080

aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg ttgagatttc   4140

acaagcaatg cgagttgtaa aataccagct ctacaagaag ctaggctctg tgacggcata   4200

gttttcagta gctttatcac aatattcaca atggagaatt atatgacatg gtagcagaaa   4260

taggcccttt tatgtgttgc ttctatttta cctcaaattg tagatatagg gtaatcaata   4320

aaatccatcc atgcctttca cacactaagt                                    4350


<210>  4091
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  4091

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala 



<210>  4092
<211>  4231
<212>  DNA
<213>  Homo sapiens

<400>  4092
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2100

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2160

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2220

tgaatcaaac ccggagttct tgaaaggatc gtccgcggga gtaataaaat caagttcgtt   2280

gttaaaaaac ctgaactagt tatttcctac ttgcctcctg ggatggctag taaaataaac   2340

actaaagctt tgcagtcccc caaaagacca cgaagtcctg ggagtaattc aaaggttcct   2400

gaaattgagg tcaccgtgga aggccctaat aacaacaatc ctcaaacctc agctgttcga   2460

accccgaccc agactaacgg ttctaacgtt cccttcaagc cacgagggag agagttttcc   2520

tttgaggcct ggaatgccaa aatcacggac ctaaaacaga aagttgaaaa tctcttcaat   2580

gagaaatgtg gggaagctct tggccttaaa caagctgtga aggtgccgtt cgcgttattt   2640

gagtctttcc cggaagactt ttatgtggaa ggcttacctg agggtgtgcc attccgaaga   2700

ccatcgactt ttggcattcc gaggctggag aagatactca gaaacaaagc caaaattaag   2760

ttcatcatta aaaagcccga aatgtttgag acggcgatta aggagagcac ctcctctaag   2820

agccctccca gaaaaataaa ttcatcaccc aatgttaata ctactgcatc aggtgttgaa   2880

gaccttaaca tcattcaggt gacaattcca gatgatgata atgaaagact ctcgaaagtt   2940

gaaaaagcta gacagctaag agaacaagtg aatgacctct ttagtcggaa atttggtgaa   3000

gctattggta tgggttttcc tgtgaaagtt ccctacagga aaatcacaat taaccctggc   3060

tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca aagcccccag ctacctggaa   3120

atcagctcca tgagaaggat cttagactct gccgagttta tcaaattcac ggtcattaga   3180

ccatttccag gacttgtgat taataaccag ctggttgatc agagtgagtc agaaggcccc   3240

gtgatacaag aatcagctga accaagccag ttggaagttc cagccacaga agaaataaaa   3300

gagactgatg gaagctctca gatcaagcaa gaaccagacc ccacgtggta gacctcttcc   3360

ctcctaggag ccttgagtta cggtgtttat tttccaatca agtgaagata tctcctactt   3420

ctcctactgg aacatctcag cttctgcagt gaagaaaaat tcctgtgata gttcagttct   3480

ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat cctttgttca cggctctcct   3540

taatgactga gtgaacagtt cctatctgta tatttgacta aaccttttcc taagctatct   3600

ctcatggttc ctatgttttt ttatcataat taaaagcaaa accatctgga tcacctaaca   3660

gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa tacagagaga acctcttcca   3720

cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga agttgaagat cgggttgagg   3780

attggggcta gctcgatgac actaaggccc caacatcgcg ggacctgctg tggcgcggat   3840

tcttaggaac gctgttctag ccggccccct ctccaggggt cgccgtggcc ggcattattt   3900

cctagttctt cttgtaaccc tgaggtgcca gcgcggggag tgaggagggg tcagggggct   3960

aaggatgcaa cctctgacgt tctgcgcctt cctaggagag tcttacatgt gttgagattt   4020

cacaagcaat gcgagttgta aaataccagc tctacaagaa gctaggctct gtgacggcat   4080

agttttcagt agctttatca caatattcac aatggagaat tatatgacat ggtagcagaa   4140

ataggccctt ttatgtgttg cttctatttt acctcaaatt gtagatatag ggtaatcaat   4200

aaaatccatc catgcctttc acacactaag t                                  4231


<210>  4093
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  4093

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys 
        595                 600                 605


Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu 
    610                 615                 620


Asn 
625


<210>  4094
<211>  7793
<212>  DNA
<213>  Homo sapiens

<400>  4094
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1860

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1920

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1980

aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc   2040

ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt   2100

tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa   2160

taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg   2220

ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg   2280

ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga gggagagagt   2340

tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct   2400

tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt   2460

tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc   2520

gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa   2580

ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct   2640

ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg   2700

ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga   2760

aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg   2820

gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc   2880

ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc   2940

tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca   3000

ttaggtaagt gagagtttcc tgcttagtca caggagcgaa tctggagctc atgaggctga   3060

ctcttctaaa atgcagccac aggtagtcat cgaatccggc ttcctatgct gtgcaatcaa   3120

caaatcaaaa taacttgtgt catcattaga atgtcagatg tgcttctacg aactaagctg   3180

actcttttaa ttctttggca aagggttggc aaactaggac tgtttgccaa attcaggctg   3240

cctcctattt ttagagtctt cctgaaacac agctacaccc gtattatcca tggctgcttt   3300

cctgtcacag tgagtaagta gctgggactg agaaggcatg gcctccaaag tctaaaatat   3360

ttactctcta gcactttgta gaaaaacctt agctaggcac agtggctaac gcctgtaatc   3420

ccagcatttt gggaggccaa ggcaggcaga tcacctgagg tcaggagttc cagaccagcc   3480

tggccaacat ggtgaaatcc catctctaca aaaataaaac agttagctgg gcatgatggc   3540

gggtgcctgt aatcccagct actcgggagg ctgaggcagg atagtcgctt gaacccagga   3600

ggtggaggtt gcaatgagcc aagatcatgc cactgcactc cagcctggac gacagagtga   3660

gactccatca caagaaaaaa agaactttgt caacctctgt cttagggcgc cttgtcacag   3720

gcttcgggtc agacggattc aaccttgcat cagccatttg ttagccaggt cactctgttc   3780

tttgtctgta aatgagattg atcgttgttc ccactgagag tgtcagctcc ttcccgtaga   3840

gcaggcatga tgattgtact cacctctgac accattgtga gtgccacatt ccttcccacg   3900

tccttgtcac tgtaagagat gcccacctga gcaccaaccc caggttatct tcccctttgt   3960

cttccagccc cccagaaaca gctacgactc aacctaccca atcatttcat catcagattg   4020

ccactgtctc tagttcaggt ctcttgggac tggcactcag aaatctcata ataaatcctc   4080

ttgaggcttc tcatacactc gtcttcttcc aatcttcttt ccctcaaaat ctcatatttt   4140

ggttccactt cacccaccgt cattctccat atcactccca ggagttaggc aaaaagcccc   4200

ttccgttctt ccgtatgtta aacttagaat cactctgttc cctgctctgc gtttctattt   4260

tttgtttttc ctccatttac tagtagctta acactttcta acagtgttct tattattgat   4320

acgtatctat ctcttccata agcttataag gtcacggata atacttctca ttgtagtacg   4380

taaatgacgt gggctagata tgagttgaat aaacagttat acctgtaaat tcttacagag   4440

tgaaaataaa ttgttatact ttacaatttg tttctctctt tagaccattt ccaggacttg   4500

tgattaataa ccgtgagtat tttgtgaagt gttttgtttt tgttttttcc tggggtctga   4560

cgtgtgtgcg tgtgagtgtg tatacatgct taacgtatat cacgttactt cacctatgtc   4620

agtaaccagg ccaaatactt gttttagccc tcagtaaaaa caccaggcac ttcctagttg   4680

taaaattatt caagcttctt aacttcctat cctcgatgca cttaatcata aaatggtaat   4740

aatagcaccg attttggggg agtcgttcca gtagatggaa agcatctgga acaggtgtca   4800

gcaagctcct gccgacgtgt atgcataaag ttttattgaa accaccatcg tgtccatttg   4860

tttatggcag aactgagaga tggcagcagc aagtgtgtgc ctgcaaaacc taaaatattt   4920

actaattggc tctgcaagaa aagagtttgc atccccctaa cctagaacag tgtctagcct   4980

ctagtatgtg tttagcctac agtatgtgct cagcgaatac aatctatatt tattactgct   5040

tttatgactg ttataattac tgtgcttgga tttcgttaca aagtaagtca caatgtgcct   5100

gcttctgtta gtatttcagc acagtgcctg gcacacatgg ggctctcaaa tattgctgag   5160

cgagtgaaca aatgtccttt caattcctta acgttgatgt cattttcaat agtattttga   5220

gccaaactta attttgcgag tgtgttttgt tttcttaact ttattattaa aaatgtataa   5280

aagtgaggcc aggcgtggtg gctcacgcct gtaatcccag cagtttggga ggctgaggca   5340

ggcggatcag ttgaggttgg gagttggaga ccagcccgtc caacatggtg aaagcctgtc   5400

tctactaaaa atacaaaaat cagctgggtg tggtggcgcg tgcctgtaat cccagctact   5460

caggaggctg aggcaggaga gttgcttgaa tcctagaggt ggaggttgca gtgagctgag   5520

atcgtgccat tgcactccag cctgggcaac aagagcaaaa ctctgtccca ataaataaat   5580

aaataaaatg ttctcttttg ttcctgttct tgtgcggtag tgtggtatag agttttatgg   5640

taattactgt gaattagtga ttctgaggga catatcagaa ctctgaggtt tgtttccttc   5700

tcatcttgag ggaaacagca aatgtatgtt aaaatgcttt tccaagggaa caacacatcc   5760

ttacattatt taaaccaatc tgcttcattt tcagagctgg ttgatcagag tgagtcagaa   5820

ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc cacagaagaa   5880

ataaaagaga ctgatggaag ctctcagatc aagcaagaac cagaccccac gtggtagacc   5940

tcttccctcc tagggtaaat cagcttctgt gtcagggatg ctgtgtggtg tccatctgaa   6000

ccccctgcat acgcgtagct aatgtgatct ccccactttc acataagatg gtggccctgc   6060

cttcagggaa tgtgggagcc aggtgggagc cttcccggat atttaagcta gaagattcta   6120

cagggagatt ctccttggat caatatatgt ctctcagtca aagatgtaaa agcacttttg   6180

ccttaaaaag aatgttctgt ttctaaatag agtcaacgtt gtcctcctca ttggaattca   6240

ctatgagtca gaatcattag actgactttt ttttttccat agtaatagta ttttgcagag   6300

tctcacagag ctgcagatct tttgttcatc ttgcagagtt aacaagtctg atcctgttag   6360

tccagatttc ttaaatttgg ccaagttata ataggagcag tagcttgaga cccgaagtca   6420

ggaaactttg acaatggatt ttttttttta atccagagac ttgtactgga atttgcctta   6480

ccctgtcagc tcatggactt aaggtttcat cccgctttat gagtgcttct gaatccaagt   6540

cattgttacc tgaatttgca aattaagttg tgatattcgt gactgttaaa ttcctgtaat   6600

tagattaacc tctttgcttg cttgtttgtt ttctctccta ttttagctta aagtatcagt   6660

ggttgagaag agcttttcgg acctgttact accccaagct gtgtaatata cttgtataac   6720

agaaatacct tctatacaaa cctttttttc tacttttaga tagaaatgtc tactttttca   6780

gcagttctgt gaattaaaga gcagagtgac tgtgggtctg gaatggctgg tgtacttggg   6840

aatgtactat caggatttta cagcaatgct gggaaatgac agggaaaatg acaggaatga   6900

atctcaccag attttttatg tactcagcag agccttgagt tacggtgttt attttccaat   6960

caagtgaaga tatctcctac ttctcctact ggaacatctc agcttctgca gtgaagaaaa   7020

attcctgtga tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat catttaaatg   7080

atcctttgtt cacggctctc cttaatgact gagtgaacag ttcctatctg tatatttgac   7140

taaacctttt cctaagctat ctctcatggt tcctatgttt ttttatcata attaaaagca   7200

aaaccatctg gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa ttatagagga   7260

aatacagaga gaacctcttc cacttttact tttcgtccaa ataaaatgca tggtgtacca   7320

gaagttgaag atcgggttga ggattggggc tagctcgatg acactaaggc cccaacatcg   7380

cgggacctgc tgtggcgcgg attcttagga acgctgttct agccggcccc ctctccaggg   7440

gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg   7500

agtgaggagg ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc ttcctaggag   7560

agtcttacat gtgttgagat ttcacaagca atgcgagttg taaaatacca gctctacaag   7620

aagctaggct ctgtgacggc atagttttca gtagctttat cacaatattc acaatggaga   7680

attatatgac atggtagcag aaataggccc ttttatgtgt tgcttctatt ttacctcaaa   7740

ttgtagatat agggtaatca ataaaatcca tccatgcctt tcacacacta agt          7793


<210>  4095
<211>  807
<212>  PRT
<213>  Homo sapiens

<400>  4095

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg 
            420                 425                 430


Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe 
        435                 440                 445


Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val 
    450                 455                 460


Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly 
465                 470                 475                 480


Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg 
                485                 490                 495


Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu 
            500                 505                 510


Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr 
        515                 520                 525


Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser 
    530                 535                 540


Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn 
545                 550                 555                 560


Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn 
                565                 570                 575


Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn 
            580                 585                 590


Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu 
        595                 600                 605


Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe 
    610                 615                 620


Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro 
625                 630                 635                 640


Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu 
                645                 650                 655


Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys 
            660                 665                 670


Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser 
        675                 680                 685


Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser 
    690                 695                 700


Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp 
705                 710                 715                 720


Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln 
                725                 730                 735


Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly 
            740                 745                 750


Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys 
        755                 760                 765


Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser 
    770                 775                 780


Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe 
785                 790                 795                 800


Ile Lys Phe Thr Val Ile Arg 
                805


<210>  4096
<211>  7392
<212>  DNA
<213>  Homo sapiens

<400>  4096
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   2040

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2100

gaaatttgct tagatttgtt gacagcggtt tcctggagtg ctgtcttgag aacgattctg   2160

aggaggctca gcaagaaaga gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa   2220

ctcaagctct tggactcacc gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc   2280

cggagttctt gtatgtggaa ggcttgccag aggggattcc cttccgaagc cctacctggt   2340

ttggaattcc acgacttgaa aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta   2400

aaaaacctga actagttatt tcctacttgc ctcctgggat ggctagtaaa ataaacacta   2460

aagctttgca gtcccccaaa agaccacgaa gtcctgggag taattcaaag gttcctgaaa   2520

ttgaggtcac cgtggaaggc cctaataaca acaatcctca aacctcagct gttcgaaccc   2580

cgacccagac taacggttct aacgttccct tcaagccacg agggagagag ttttcctttg   2640

aggcctggaa tgccaaaatc acggacctaa aacagaaagt tgaaaatctc ttcaatgaga   2700

aatgtgggga agctcttggc cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt   2760

ctttcccgga agacttttat gtggaaggct tacctgaggg tgtgccattc cgaagaccat   2820

cgacttttgg cattccgagg ctggagaaga tactcagaaa caaagccaaa attaagttca   2880

tcattaaaaa gcccgaaatg tttgagacgg cgattaagga gagcacctcc tctaagagcc   2940

ctcccagaaa aataaattca tcacccaatg ttaatactac tgcatcaggt gttgaagacc   3000

ttaacatcat tcaggtgaca attccagatg atgataatga aagactctcg aaagttgaaa   3060

aagctagaca gctaagagaa caagtgaatg acctctttag tcggaaattt ggtgaagcta   3120

ttggtatggg ttttcctgtg aaagttccct acaggaaaat cacaattaac cctggctgtg   3180

tggtggttga tggcatgccc ccgggggtgt ccttcaaagc ccccagctac ctggaaatca   3240

gctccatgag aaggatctta gactctgccg agtttatcaa attcacggtc attaggtaag   3300

tgagagtttc ctgcttagtc acaggagcga atctggagct catgaggctg actcttctaa   3360

aatgcagcca caggtagtca tcgaatccgg cttcctatgc tgtgcaatca acaaatcaaa   3420

ataacttgtg tcatcattag aatgtcagat gtgcttctac gaactaagct gactctttta   3480

attctttggc aaagggttgg caaactagga ctgtttgcca aattcaggct gcctcctatt   3540

tttagagtct tcctgaaaca cagctacacc cgtattatcc atggctgctt tcctgtcaca   3600

gtgagtaagt agctgggact gagaaggcat ggcctccaaa gtctaaaata tttactctct   3660

agcactttgt agaaaaacct tagctaggca cagtggctaa cgcctgtaat cccagcattt   3720

tgggaggcca aggcaggcag atcacctgag gtcaggagtt ccagaccagc ctggccaaca   3780

tggtgaaatc ccatctctac aaaaataaaa cagttagctg ggcatgatgg cgggtgcctg   3840

taatcccagc tactcgggag gctgaggcag gatagtcgct tgaacccagg aggtggaggt   3900

tgcaatgagc caagatcatg ccactgcact ccagcctgga cgacagagtg agactccatc   3960

acaagaaaaa aagaactttg tcaacctctg tcttagggcg ccttgtcaca ggcttcgggt   4020

cagacggatt caaccttgca tcagccattt gttagccagg tcactctgtt ctttgtctgt   4080

aaatgagatt gatcgttgtt cccactgaga gtgtcagctc cttcccgtag agcaggcatg   4140

atgattgtac tcacctctga caccattgtg agtgccacat tccttcccac gtccttgtca   4200

ctgtaagaga tgcccacctg agcaccaacc ccaggttatc ttcccctttg tcttccagcc   4260

ccccagaaac agctacgact caacctaccc aatcatttca tcatcagatt gccactgtct   4320

ctagttcagg tctcttggga ctggcactca gaaatctcat aataaatcct cttgaggctt   4380

ctcatacact cgtcttcttc caatcttctt tccctcaaaa tctcatattt tggttccact   4440

tcacccaccg tcattctcca tatcactccc aggagttagg caaaaagccc cttccgttct   4500

tccgtatgtt aaacttagaa tcactctgtt ccctgctctg cgtttctatt ttttgttttt   4560

cctccattta ctagtagctt aacactttct aacagtgttc ttattattga tacgtatcta   4620

tctcttccat aagcttataa ggtcacggat aatacttctc attgtagtac gtaaatgacg   4680

tgggctagat atgagttgaa taaacagtta tacctgtaaa ttcttacaga gtgaaaataa   4740

attgttatac tttacaattt gtttctctct ttagaccatt tccaggactt gtgattaata   4800

accgtgagta ttttgtgaag tgttttgttt ttgttttttc ctggggtctg acgtgtgtgc   4860

gtgtgagtgt gtatacatgc ttaacgtata tcacgttact tcacctatgt cagtaaccag   4920

gccaaatact tgttttagcc ctcagtaaaa acaccaggca cttcctagtt gtaaaattat   4980

tcaagcttct taacttccta tcctcgatgc acttaatcat aaaatggtaa taatagcacc   5040

gattttgggg gagtcgttcc agtagatgga aagcatctgg aacaggtgtc agcaagctcc   5100

tgccgacgtg tatgcataaa gttttattga aaccaccatc gtgtccattt gtttatggca   5160

gaactgagag atggcagcag caagtgtgtg cctgcaaaac ctaaaatatt tactaattgg   5220

ctctgcaaga aaagagtttg catcccccta acctagaaca gtgtctagcc tctagtatgt   5280

gtttagccta cagtatgtgc tcagcgaata caatctatat ttattactgc ttttatgact   5340

gttataatta ctgtgcttgg atttcgttac aaagtaagtc acaatgtgcc tgcttctgtt   5400

agtatttcag cacagtgcct ggcacacatg gggctctcaa atattgctga gcgagtgaac   5460

aaatgtcctt tcaattcctt aacgttgatg tcattttcaa tagtattttg agccaaactt   5520

aattttgcga gtgtgttttg ttttcttaac tttattatta aaaatgtata aaagtgaggc   5580

caggcgtggt ggctcacgcc tgtaatccca gcagtttggg aggctgaggc aggcggatca   5640

gttgaggttg ggagttggag accagcccgt ccaacatggt gaaagcctgt ctctactaaa   5700

aatacaaaaa tcagctgggt gtggtggcgc gtgcctgtaa tcccagctac tcaggaggct   5760

gaggcaggag agttgcttga atcctagagg tggaggttgc agtgagctga gatcgtgcca   5820

ttgcactcca gcctgggcaa caagagcaaa actctgtccc aataaataaa taaataaaat   5880

gttctctttt gttcctgttc ttgtgcggta gtgtggtata gagttttatg gtaattactg   5940

tgaattagtg attctgaggg acatatcaga actctgaggt ttgtttcctt ctcatcttga   6000

gggaaacagc aaatgtatgt taaaatgctt ttccaaggga acaacacatc cttacattat   6060

ttaaaccaat ctgcttcatt ttcagagctg gttgatcaga gtgagtcaga aggccccgtg   6120

atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag   6180

actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc   6240

ctaggcttaa agtatcagtg gttgagaaga gcttttcgga cctgttacta ccccaagctg   6300

tgtaatatac ttgtataaca gaaatacctt ctatacaaac ctttttttct acttttagat   6360

agaaatgtct actttttcag cagttctgtg aattaaagag cagagtgact gtgggtctgg   6420

aatggctggt gtacttggga atgtactatc aggattttac agcaatgctg ggaaatgaca   6480

gggaaaatga caggaatgaa tctcaccaga ttttttatgt actcagcaga gccttgagtt   6540

acggtgttta ttttccaatc aagtgaagat atctcctact tctcctactg gaacatctca   6600

gcttctgcag tgaagaaaaa ttcctgtgat agttcagttc tttagttttt ctatttgaaa   6660

aaaaaaaatc atttaaatga tcctttgttc acggctctcc ttaatgactg agtgaacagt   6720

tcctatctgt atatttgact aaaccttttc ctaagctatc tctcatggtt cctatgtttt   6780

tttatcataa ttaaaagcaa aaccatctgg atcacctaac agtcagaggt cagtatctca   6840

gcgtgtgaat tatagaggaa atacagagag aacctcttcc acttttactt ttcgtccaaa   6900

taaaatgcat ggtgtaccag aagttgaaga tcgggttgag gattggggct agctcgatga   6960

cactaaggcc ccaacatcgc gggacctgct gtggcgcgga ttcttaggaa cgctgttcta   7020

gccggccccc tctccagggg tcgccgtggc cggcattatt tcctagttct tcttgtaacc   7080

ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc taaggatgca acctctgacg   7140

ttctgcgcct tcctaggaga gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt   7200

aaaataccag ctctacaaga agctaggctc tgtgacggca tagttttcag tagctttatc   7260

acaatattca caatggagaa ttatatgaca tggtagcaga aataggccct tttatgtgtt   7320

gcttctattt tacctcaaat tgtagatata gggtaatcaa taaaatccat ccatgccttt   7380

cacacactaa gt                                                       7392


<210>  4097
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  4097

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala 



<210>  4098
<211>  5011
<212>  DNA
<213>  Homo sapiens

<400>  4098
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagc tcaagctctt ggactcaccg   1980

aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag   2040

gcttgccaga ggggattccc ttccgaagcc ctacctggtt tggaattcca cgacttgaaa   2100

ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt   2160

cctacttgcc tcctgggatg gctagtaaaa taaacactaa agctttgcag tcccccaaaa   2220

gaccacgaag tcctgggagt aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc   2280

ctaataacaa caatcctcaa acctcagctg ttcgaacccc gacccagact aacggttcta   2340

acgttccctt caagccacga gggagagagt tttcctttga ggcctggaat gccaaaatca   2400

cggacctaaa acagaaagtt gaaaatctct tcaatgagaa atgtggggaa gctcttggcc   2460

ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc tttcccggaa gacttttatg   2520

tggaaggctt acctgagggt gtgccattcc gaagaccatc gacttttggc attccgaggc   2580

tggagaagat actcagaaac aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt   2640

ttgagacggc gattaaggag agcacctcct ctaagagccc tcccagaaaa ataaattcat   2700

cacccaatgt taatactact gcatcaggtg ttgaagacct taacatcatt caggtgacaa   2760

ttccagatga tgataatgaa agactctcga aagttgaaaa agctagacag ctaagagaac   2820

aagtgaatga cctctttagt cggaaatttg gtgaagctat tggtatgggt tttcctgtga   2880

aagttcccta caggaaaatc acaattaacc ctggctgtgt ggtggttgat ggcatgcccc   2940

cgggggtgtc cttcaaagcc cccagctacc tggaaatcag ctccatgaga aggatcttag   3000

actctgccga gtttatcaaa ttcacggtca ttagaccatt tccaggactt gtgattaata   3060

accagctggt tgatcagagt gagtcagaag gccccgtgat acaagaatca gctgaaccaa   3120

gccagttgga agttccagcc acagaaggta aaaggacctc ttccctccta gggtaaatca   3180

gcttctgtgt cagggatgct gtgtggtgtc catctgaacc ccctgcatac gcgtagctaa   3240

tgtgatctcc ccactttcac ataagatggt ggccctgcct tcagggaatg tgggagccag   3300

gtgggagcct tcccggatat ttaagctaga agattctaca gggagattct ccttggatca   3360

atatatgtct ctcagtcaaa gatgtaaaag cacttttgcc ttaaaaagaa tgttctgttt   3420

ctaaatagag tcaacgttgt cctcctcatt ggaattcact atgagtcaga atcattagac   3480

tgactttttt ttttccatag taatagtatt ttgcagagtc tcacagagct gcagatcttt   3540

tgttcatctt gcagagttaa caagtctgat cctgttagtc cagatttctt aaatttggcc   3600

aagttataat aggagcagta gcttgagacc cgaagtcagg aaactttgac aatggatttt   3660

tttttttaat ccagagactt gtactggaat ttgccttacc ctgtcagctc atggacttaa   3720

ggtttcatcc cgctttatga gtgcttctga atccaagtca ttgttacctg aatttgcaaa   3780

ttaagttgtg atattcgtga ctgttaaatt cctgtaatta gattaacctc tttgcttgct   3840

tgtttgtttt ctctcctatt ttagcttaaa gtatcagtgg ttgagaagag cttttcggac   3900

ctgttactac cccaagctgt gtaatatact tgtataacag aaataccttc tatacaaacc   3960

tttttttcta cttttagata gaaatgtcta ctttttcagc agttctgtga attaaagagc   4020

agagtgactg tgggtctgga atggctggtg tacttgggaa tgtactatca ggattttaca   4080

gcaatgctgg gaaatgacag ggaaaatgac aggaatgaat ctcaccagat tttttatgta   4140

ctcagcagag ccttgagtta cggtgtttat tttccaatca agtgaagata tctcctactt   4200

ctcctactgg aacatctcag cttctgcagt gaagaaaaat tcctgtgata gttcagttct   4260

ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat cctttgttca cggctctcct   4320

taatgactga gtgaacagtt cctatctgta tatttgacta aaccttttcc taagctatct   4380

ctcatggttc ctatgttttt ttatcataat taaaagcaaa accatctgga tcacctaaca   4440

gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa tacagagaga acctcttcca   4500

cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga agttgaagat cgggttgagg   4560

attggggcta gctcgatgac actaaggccc caacatcgcg ggacctgctg tggcgcggat   4620

tcttaggaac gctgttctag ccggccccct ctccaggggt cgccgtggcc ggcattattt   4680

cctagttctt cttgtaaccc tgaggtgcca gcgcggggag tgaggagggg tcagggggct   4740

aaggatgcaa cctctgacgt tctgcgcctt cctaggagag tcttacatgt gttgagattt   4800

cacaagcaat gcgagttgta aaataccagc tctacaagaa gctaggctct gtgacggcat   4860

agttttcagt agctttatca caatattcac aatggagaat tatatgacat ggtagcagaa   4920

ataggccctt ttatgtgttg cttctatttt acctcaaatt gtagatatag ggtaatcaat   4980

aaaatccatc catgcctttc acacactaag t                                  5011


<210>  4099
<211>  924
<212>  PRT
<213>  Homo sapiens

<400>  4099

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala 
        515                 520                 525


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr 
    530                 535                 540


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe 
545                 550                 555                 560


Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys 
                565                 570                 575


Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly 
            580                 585                 590


Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro 
        595                 600                 605


Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val 
    610                 615                 620


Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro 
625                 630                 635                 640


Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu 
                645                 650                 655


Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys 
            660                 665                 670


Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys 
        675                 680                 685


Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp 
    690                 695                 700


Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser 
705                 710                 715                 720


Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys 
                725                 730                 735


Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys 
            740                 745                 750


Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro 
        755                 760                 765


Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln 
    770                 775                 780


Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys 
785                 790                 795                 800


Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe 
                805                 810                 815


Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys 
            820                 825                 830


Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly 
        835                 840                 845


Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg 
    850                 855                 860


Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe 
865                 870                 875                 880


Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu 
                885                 890                 895


Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro 
            900                 905                 910


Ala Thr Glu Gly Lys Arg Thr Ser Ser Leu Leu Gly 
        915                 920


<210>  4100
<211>  4510
<212>  DNA
<213>  Homo sapiens

<400>  4100
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagc   2100

tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc   2160

ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc ctacctggtt   2220

tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa   2280

aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa taaacactaa   2340

agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg ttcctgaaat   2400

tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg ttcgaacccc   2460

gacccagact aacggttcta acgttccctt caagccacga gggagagagt tttcctttga   2520

ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct tcaatgagaa   2580

atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc   2640

tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc gaagaccatc   2700

gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa ttaagttcat   2760

cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct ctaagagccc   2820

tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg ttgaagacct   2880

taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga aagttgaaaa   2940

agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg gtgaagctat   3000

tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc ctggctgtgt   3060

ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc tggaaatcag   3120

ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca ttagaccatt   3180

tccaggactt gtgattaata accagctggt tgatcagagt gagtcagaag gccccgtgat   3240

acaagaatca gctgaaccaa gccagttgga agttccagcc acagaagaaa taaaagagac   3300

tgatggaagc tctcagatca agcaagaacc agaccccacg tggtagacct cttccctcct   3360

aggcttaaag tatcagtggt tgagaagagc ttttcggacc tgttactacc ccaagctgtg   3420

taatatactt gtataacaga aataccttct atacaaacct ttttttctac ttttagatag   3480

aaatgtctac tttttcagca gttctgtgaa ttaaagagca gagtgactgt gggtctggaa   3540

tggctggtgt acttgggaat gtactatcag gattttacag caatgctggg aaatgacagg   3600

gaaaatgaca ggaatgaatc tcaccagatt ttttatgtac tcagcagagc cttgagttac   3660

ggtgtttatt ttccaatcaa gtgaagatat ctcctacttc tcctactgga acatctcagc   3720

ttctgcagtg aagaaaaatt cctgtgatag ttcagttctt tagtttttct atttgaaaaa   3780

aaaaaatcat ttaaatgatc ctttgttcac ggctctcctt aatgactgag tgaacagttc   3840

ctatctgtat atttgactaa accttttcct aagctatctc tcatggttcc tatgtttttt   3900

tatcataatt aaaagcaaaa ccatctggat cacctaacag tcagaggtca gtatctcagc   3960

gtgtgaatta tagaggaaat acagagagaa cctcttccac ttttactttt cgtccaaata   4020

aaatgcatgg tgtaccagaa gttgaagatc gggttgagga ttggggctag ctcgatgaca   4080

ctaaggcccc aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg ctgttctagc   4140

cggccccctc tccaggggtc gccgtggccg gcattatttc ctagttcttc ttgtaaccct   4200

gaggtgccag cgcggggagt gaggaggggt cagggggcta aggatgcaac ctctgacgtt   4260

ctgcgccttc ctaggagagt cttacatgtg ttgagatttc acaagcaatg cgagttgtaa   4320

aataccagct ctacaagaag ctaggctctg tgacggcata gttttcagta gctttatcac   4380

aatattcaca atggagaatt atatgacatg gtagcagaaa taggcccttt tatgtgttgc   4440

ttctatttta cctcaaattg tagatatagg gtaatcaata aaatccatcc atgcctttca   4500

cacactaagt                                                          4510


<210>  4101
<211>  974
<212>  PRT
<213>  Homo sapiens

<400>  4101

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala 
545                 550                 555                 560


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
                565                 570                 575


Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile 
            580                 585                 590


Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile 
        595                 600                 605


Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu 
    610                 615                 620


Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys 
625                 630                 635                 640


Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys 
                645                 650                 655


Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro 
            660                 665                 670


Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val 
        675                 680                 685


Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala 
    690                 695                 700


Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys 
705                 710                 715                 720


Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala 
                725                 730                 735


Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu 
            740                 745                 750


Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu 
        755                 760                 765


Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro 
    770                 775                 780


Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro 
785                 790                 795                 800


Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly 
                805                 810                 815


Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn 
            820                 825                 830


Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val 
        835                 840                 845


Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe 
    850                 855                 860


Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val 
865                 870                 875                 880


Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr 
                885                 890                 895


Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile 
            900                 905                 910


Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln 
        915                 920                 925


Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala 
    930                 935                 940


Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr 
945                 950                 955                 960


Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
                965                 970


<210>  4102
<211>  5088
<212>  DNA
<213>  Homo sapiens

<400>  4102
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagctca   2040

agctcttgga ctcaccgagg cagtaaaagt accatatcct gtgtttgaat caaacccgga   2100

gttcttgtat gtggaaggct tgccagaggg gattcccttc cgaagcccta cctggtttgg   2160

aattccacga cttgaaagga tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa   2220

acctgaacta gttatttcct acttgcctcc tgggatggct agtaaaataa acactaaagc   2280

tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga   2340

ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc tcagctgttc gaaccccgac   2400

ccagactaac ggttctaacg ttcccttcaa gccacgaggg agagagtttt cctttgaggc   2460

ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa aatctcttca atgagaaatg   2520

tggggaagct cttggcctta aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt   2580

cccggaagac ttttatgtgg aaggcttacc tgagggtgtg ccattccgaa gaccatcgac   2640

ttttggcatt ccgaggctgg agaagatact cagaaacaaa gccaaaatta agttcatcat   2700

taaaaagccc gaaatgtttg agacggcgat taaggagagc acctcctcta agagccctcc   2760

cagaaaaata aattcatcac ccaatgttaa tactactgca tcaggtgttg aagaccttaa   2820

catcattcag gtgacaattc cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc   2880

tagacagcta agagaacaag tgaatgacct ctttagtcgg aaatttggtg aagctattgg   2940

tatgggtttt cctgtgaaag ttccctacag gaaaatcaca attaaccctg gctgtgtggt   3000

ggttgatggc atgcccccgg gggtgtcctt caaagccccc agctacctgg aaatcagctc   3060

catgagaagg atcttagact ctgccgagtt tatcaaattc acggtcatta gaccatttcc   3120

aggacttgtg attaataacc agctggttga tcagagtgag tcagaaggcc ccgtgataca   3180

agaatcagct gaaccaagcc agttggaagt tccagccaca gaaggtaaaa ggacctcttc   3240

cctcctaggg taaatcagct tctgtgtcag ggatgctgtg tggtgtccat ctgaaccccc   3300

tgcatacgcg tagctaatgt gatctcccca ctttcacata agatggtggc cctgccttca   3360

gggaatgtgg gagccaggtg ggagccttcc cggatattta agctagaaga ttctacaggg   3420

agattctcct tggatcaata tatgtctctc agtcaaagat gtaaaagcac ttttgcctta   3480

aaaagaatgt tctgtttcta aatagagtca acgttgtcct cctcattgga attcactatg   3540

agtcagaatc attagactga cttttttttt tccatagtaa tagtattttg cagagtctca   3600

cagagctgca gatcttttgt tcatcttgca gagttaacaa gtctgatcct gttagtccag   3660

atttcttaaa tttggccaag ttataatagg agcagtagct tgagacccga agtcaggaaa   3720

ctttgacaat ggattttttt ttttaatcca gagacttgta ctggaatttg ccttaccctg   3780

tcagctcatg gacttaaggt ttcatcccgc tttatgagtg cttctgaatc caagtcattg   3840

ttacctgaat ttgcaaatta agttgtgata ttcgtgactg ttaaattcct gtaattagat   3900

taacctcttt gcttgcttgt ttgttttctc tcctatttta gcttaaagta tcagtggttg   3960

agaagagctt ttcggacctg ttactacccc aagctgtgta atatacttgt ataacagaaa   4020

taccttctat acaaaccttt ttttctactt ttagatagaa atgtctactt tttcagcagt   4080

tctgtgaatt aaagagcaga gtgactgtgg gtctggaatg gctggtgtac ttgggaatgt   4140

actatcagga ttttacagca atgctgggaa atgacaggga aaatgacagg aatgaatctc   4200

accagatttt ttatgtactc agcagagcct tgagttacgg tgtttatttt ccaatcaagt   4260

gaagatatct cctacttctc ctactggaac atctcagctt ctgcagtgaa gaaaaattcc   4320

tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct   4380

ttgttcacgg ctctccttaa tgactgagtg aacagttcct atctgtatat ttgactaaac   4440

cttttcctaa gctatctctc atggttccta tgttttttta tcataattaa aagcaaaacc   4500

atctggatca cctaacagtc agaggtcagt atctcagcgt gtgaattata gaggaaatac   4560

agagagaacc tcttccactt ttacttttcg tccaaataaa atgcatggtg taccagaagt   4620

tgaagatcgg gttgaggatt ggggctagct cgatgacact aaggccccaa catcgcggga   4680

cctgctgtgg cgcggattct taggaacgct gttctagccg gccccctctc caggggtcgc   4740

cgtggccggc attatttcct agttcttctt gtaaccctga ggtgccagcg cggggagtga   4800

ggaggggtca gggggctaag gatgcaacct ctgacgttct gcgccttcct aggagagtct   4860

tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa taccagctct acaagaagct   4920

aggctctgtg acggcatagt tttcagtagc tttatcacaa tattcacaat ggagaattat   4980

atgacatggt agcagaaata ggccctttta tgtgttgctt ctattttacc tcaaattgta   5040

gatatagggt aatcaataaa atccatccat gcctttcaca cactaagt                5088


<210>  4103
<211>  943
<212>  PRT
<213>  Homo sapiens

<400>  4103

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu 
    530                 535                 540


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
545                 550                 555                 560


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
                565                 570                 575


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
            580                 585                 590


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
        595                 600                 605


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
    610                 615                 620


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
625                 630                 635                 640


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
                645                 650                 655


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
            660                 665                 670


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
        675                 680                 685


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
    690                 695                 700


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
705                 710                 715                 720


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
                725                 730                 735


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
            740                 745                 750


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
        755                 760                 765


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
    770                 775                 780


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
785                 790                 795                 800


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
                805                 810                 815


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
            820                 825                 830


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
        835                 840                 845


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
    850                 855                 860


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
865                 870                 875                 880


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
                885                 890                 895


Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser 
            900                 905                 910


Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu 
        915                 920                 925


Glu Val Pro Ala Thr Glu Gly Lys Arg Thr Ser Ser Leu Leu Gly 
    930                 935                 940


<210>  4104
<211>  7726
<212>  DNA
<213>  Homo sapiens

<400>  4104
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1860

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1920

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1980

aatcaaaccc ggagttcttg aaaggatcgt ccgcgggagt aataaaatca agttcgttgt   2040

taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta aaataaacac   2100

taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa aggttcctga   2160

aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag ctgttcgaac   2220

cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag agttttcctt   2280

tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc tcttcaatga   2340

gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg cgttatttga   2400

gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat tccgaagacc   2460

atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca aaattaagtt   2520

catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct cctctaagag   2580

ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag gtgttgaaga   2640

ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct cgaaagttga   2700

aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat ttggtgaagc   2760

tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta accctggctg   2820

tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct acctggaaat   2880

cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg tcattaggta   2940

agtgagagtt tcctgcttag tcacaggagc gaatctggag ctcatgaggc tgactcttct   3000

aaaatgcagc cacaggtagt catcgaatcc ggcttcctat gctgtgcaat caacaaatca   3060

aaataacttg tgtcatcatt agaatgtcag atgtgcttct acgaactaag ctgactcttt   3120

taattctttg gcaaagggtt ggcaaactag gactgtttgc caaattcagg ctgcctccta   3180

tttttagagt cttcctgaaa cacagctaca cccgtattat ccatggctgc tttcctgtca   3240

cagtgagtaa gtagctggga ctgagaaggc atggcctcca aagtctaaaa tatttactct   3300

ctagcacttt gtagaaaaac cttagctagg cacagtggct aacgcctgta atcccagcat   3360

tttgggaggc caaggcaggc agatcacctg aggtcaggag ttccagacca gcctggccaa   3420

catggtgaaa tcccatctct acaaaaataa aacagttagc tgggcatgat ggcgggtgcc   3480

tgtaatccca gctactcggg aggctgaggc aggatagtcg cttgaaccca ggaggtggag   3540

gttgcaatga gccaagatca tgccactgca ctccagcctg gacgacagag tgagactcca   3600

tcacaagaaa aaaagaactt tgtcaacctc tgtcttaggg cgccttgtca caggcttcgg   3660

gtcagacgga ttcaaccttg catcagccat ttgttagcca ggtcactctg ttctttgtct   3720

gtaaatgaga ttgatcgttg ttcccactga gagtgtcagc tccttcccgt agagcaggca   3780

tgatgattgt actcacctct gacaccattg tgagtgccac attccttccc acgtccttgt   3840

cactgtaaga gatgcccacc tgagcaccaa ccccaggtta tcttcccctt tgtcttccag   3900

ccccccagaa acagctacga ctcaacctac ccaatcattt catcatcaga ttgccactgt   3960

ctctagttca ggtctcttgg gactggcact cagaaatctc ataataaatc ctcttgaggc   4020

ttctcataca ctcgtcttct tccaatcttc tttccctcaa aatctcatat tttggttcca   4080

cttcacccac cgtcattctc catatcactc ccaggagtta ggcaaaaagc cccttccgtt   4140

cttccgtatg ttaaacttag aatcactctg ttccctgctc tgcgtttcta ttttttgttt   4200

ttcctccatt tactagtagc ttaacacttt ctaacagtgt tcttattatt gatacgtatc   4260

tatctcttcc ataagcttat aaggtcacgg ataatacttc tcattgtagt acgtaaatga   4320

cgtgggctag atatgagttg aataaacagt tatacctgta aattcttaca gagtgaaaat   4380

aaattgttat actttacaat ttgtttctct ctttagacca tttccaggac ttgtgattaa   4440

taaccgtgag tattttgtga agtgttttgt ttttgttttt tcctggggtc tgacgtgtgt   4500

gcgtgtgagt gtgtatacat gcttaacgta tatcacgtta cttcacctat gtcagtaacc   4560

aggccaaata cttgttttag ccctcagtaa aaacaccagg cacttcctag ttgtaaaatt   4620

attcaagctt cttaacttcc tatcctcgat gcacttaatc ataaaatggt aataatagca   4680

ccgattttgg gggagtcgtt ccagtagatg gaaagcatct ggaacaggtg tcagcaagct   4740

cctgccgacg tgtatgcata aagttttatt gaaaccacca tcgtgtccat ttgtttatgg   4800

cagaactgag agatggcagc agcaagtgtg tgcctgcaaa acctaaaata tttactaatt   4860

ggctctgcaa gaaaagagtt tgcatccccc taacctagaa cagtgtctag cctctagtat   4920

gtgtttagcc tacagtatgt gctcagcgaa tacaatctat atttattact gcttttatga   4980

ctgttataat tactgtgctt ggatttcgtt acaaagtaag tcacaatgtg cctgcttctg   5040

ttagtatttc agcacagtgc ctggcacaca tggggctctc aaatattgct gagcgagtga   5100

acaaatgtcc tttcaattcc ttaacgttga tgtcattttc aatagtattt tgagccaaac   5160

ttaattttgc gagtgtgttt tgttttctta actttattat taaaaatgta taaaagtgag   5220

gccaggcgtg gtggctcacg cctgtaatcc cagcagtttg ggaggctgag gcaggcggat   5280

cagttgaggt tgggagttgg agaccagccc gtccaacatg gtgaaagcct gtctctacta   5340

aaaatacaaa aatcagctgg gtgtggtggc gcgtgcctgt aatcccagct actcaggagg   5400

ctgaggcagg agagttgctt gaatcctaga ggtggaggtt gcagtgagct gagatcgtgc   5460

cattgcactc cagcctgggc aacaagagca aaactctgtc ccaataaata aataaataaa   5520

atgttctctt ttgttcctgt tcttgtgcgg tagtgtggta tagagtttta tggtaattac   5580

tgtgaattag tgattctgag ggacatatca gaactctgag gtttgtttcc ttctcatctt   5640

gagggaaaca gcaaatgtat gttaaaatgc ttttccaagg gaacaacaca tccttacatt   5700

atttaaacca atctgcttca ttttcagagc tggttgatca gagtgagtca gaaggccccg   5760

tgatacaaga atcagctgaa ccaagccagt tggaagttcc agccacagaa gaaataaaag   5820

agactgatgg aagctctcag atcaagcaag aaccagaccc cacgtggtag acctcttccc   5880

tcctagggta aatcagcttc tgtgtcaggg atgctgtgtg gtgtccatct gaaccccctg   5940

catacgcgta gctaatgtga tctccccact ttcacataag atggtggccc tgccttcagg   6000

gaatgtggga gccaggtggg agccttcccg gatatttaag ctagaagatt ctacagggag   6060

attctccttg gatcaatata tgtctctcag tcaaagatgt aaaagcactt ttgccttaaa   6120

aagaatgttc tgtttctaaa tagagtcaac gttgtcctcc tcattggaat tcactatgag   6180

tcagaatcat tagactgact tttttttttc catagtaata gtattttgca gagtctcaca   6240

gagctgcaga tcttttgttc atcttgcaga gttaacaagt ctgatcctgt tagtccagat   6300

ttcttaaatt tggccaagtt ataataggag cagtagcttg agacccgaag tcaggaaact   6360

ttgacaatgg attttttttt ttaatccaga gacttgtact ggaatttgcc ttaccctgtc   6420

agctcatgga cttaaggttt catcccgctt tatgagtgct tctgaatcca agtcattgtt   6480

acctgaattt gcaaattaag ttgtgatatt cgtgactgtt aaattcctgt aattagatta   6540

acctctttgc ttgcttgttt gttttctctc ctattttagc ttaaagtatc agtggttgag   6600

aagagctttt cggacctgtt actaccccaa gctgtgtaat atacttgtat aacagaaata   6660

ccttctatac aaaccttttt ttctactttt agatagaaat gtctactttt tcagcagttc   6720

tgtgaattaa agagcagagt gactgtgggt ctggaatggc tggtgtactt gggaatgtac   6780

tatcaggatt ttacagcaat gctgggaaat gacagggaaa atgacaggaa tgaatctcac   6840

cagatttttt atgtactcag cagagccttg agttacggtg tttattttcc aatcaagtga   6900

agatatctcc tacttctcct actggaacat ctcagcttct gcagtgaaga aaaattcctg   6960

tgatagttca gttctttagt ttttctattt gaaaaaaaaa aatcatttaa atgatccttt   7020

gttcacggct ctccttaatg actgagtgaa cagttcctat ctgtatattt gactaaacct   7080

tttcctaagc tatctctcat ggttcctatg tttttttatc ataattaaaa gcaaaaccat   7140

ctggatcacc taacagtcag aggtcagtat ctcagcgtgt gaattataga ggaaatacag   7200

agagaacctc ttccactttt acttttcgtc caaataaaat gcatggtgta ccagaagttg   7260

aagatcgggt tgaggattgg ggctagctcg atgacactaa ggccccaaca tcgcgggacc   7320

tgctgtggcg cggattctta ggaacgctgt tctagccggc cccctctcca ggggtcgccg   7380

tggccggcat tatttcctag ttcttcttgt aaccctgagg tgccagcgcg gggagtgagg   7440

aggggtcagg gggctaagga tgcaacctct gacgttctgc gccttcctag gagagtctta   7500

catgtgttga gatttcacaa gcaatgcgag ttgtaaaata ccagctctac aagaagctag   7560

gctctgtgac ggcatagttt tcagtagctt tatcacaata ttcacaatgg agaattatat   7620

gacatggtag cagaaatagg cccttttatg tgttgcttct attttacctc aaattgtaga   7680

tatagggtaa tcaataaaat ccatccatgc ctttcacaca ctaagt                  7726


<210>  4105
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  4105

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg 
            420                 425                 430


Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe 
        435                 440                 445


Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val 
    450                 455                 460


Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile 
465                 470                 475                 480


Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
                485                 490


<210>  4106
<211>  4243
<212>  DNA
<213>  Homo sapiens

<400>  4106
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1980

aagagatttt taatttgaaa tttgcttaga tttgttgaca gcggtttcct ggagtgctgt   2040

cttgagaacg attctgagga ggctcagcaa gaaagagtgt ttcagttgat tgggtgtgtc   2100

tgtcatggag aaggaactca agctcttgga ctcaccgagg cagtaaaagt accatatcct   2160

gtgtttgaat caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc   2220

cgaagcccta cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa   2280

atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct   2340

agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat   2400

tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc   2460

tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg   2520

agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa   2580

aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg   2640

ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg   2700

ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa   2760

gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc   2820

acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca   2880

tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga   2940

ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg   3000

aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca   3060

attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt caaagccccc   3120

agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc   3180

acggtcatta gaccatttcc aggacttgtg attaataacc agctggttga tcagagtgag   3240

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   3300

gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga ccccacgtgg   3360

tagacctctt ccctcctagg agccttgagt tacggtgttt attttccaat caagtgaaga   3420

tatctcctac ttctcctact ggaacatctc agcttctgca gtgaagaaaa attcctgtga   3480

tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat catttaaatg atcctttgtt   3540

cacggctctc cttaatgact gagtgaacag ttcctatctg tatatttgac taaacctttt   3600

cctaagctat ctctcatggt tcctatgttt ttttatcata attaaaagca aaaccatctg   3660

gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa ttatagagga aatacagaga   3720

gaacctcttc cacttttact tttcgtccaa ataaaatgca tggtgtacca gaagttgaag   3780

atcgggttga ggattggggc tagctcgatg acactaaggc cccaacatcg cgggacctgc   3840

tgtggcgcgg attcttagga acgctgttct agccggcccc ctctccaggg gtcgccgtgg   3900

ccggcattat ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg   3960

ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc ttcctaggag agtcttacat   4020

gtgttgagat ttcacaagca atgcgagttg taaaatacca gctctacaag aagctaggct   4080

ctgtgacggc atagttttca gtagctttat cacaatattc acaatggaga attatatgac   4140

atggtagcag aaataggccc ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat   4200

agggtaatca ataaaatcca tccatgcctt tcacacacta agt                     4243


<210>  4107
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  4107

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
    450                 455                 460


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
465                 470


<210>  4108
<211>  4122
<212>  DNA
<213>  Homo sapiens

<400>  4108
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   2040

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   2100

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2160

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2220

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2280

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2340

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2400

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2460

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2520

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2580

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2640

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2700

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2760

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2820

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2880

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2940

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   3000

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   3060

cggtcattag accatttcca ggacttgtga ttaataacca gctggttgat cagagtgagt   3120

cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt ccagccacag   3180

aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac cccacgtggt   3240

agacctcttc cctcctagga gccttgagtt acggtgttta ttttccaatc aagtgaagat   3300

atctcctact tctcctactg gaacatctca gcttctgcag tgaagaaaaa ttcctgtgat   3360

agttcagttc tttagttttt ctatttgaaa aaaaaaaatc atttaaatga tcctttgttc   3420

acggctctcc ttaatgactg agtgaacagt tcctatctgt atatttgact aaaccttttc   3480

ctaagctatc tctcatggtt cctatgtttt tttatcataa ttaaaagcaa aaccatctgg   3540

atcacctaac agtcagaggt cagtatctca gcgtgtgaat tatagaggaa atacagagag   3600

aacctcttcc acttttactt ttcgtccaaa taaaatgcat ggtgtaccag aagttgaaga   3660

tcgggttgag gattggggct agctcgatga cactaaggcc ccaacatcgc gggacctgct   3720

gtggcgcgga ttcttaggaa cgctgttcta gccggccccc tctccagggg tcgccgtggc   3780

cggcattatt tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga gtgaggaggg   3840

gtcagggggc taaggatgca acctctgacg ttctgcgcct tcctaggaga gtcttacatg   3900

tgttgagatt tcacaagcaa tgcgagttgt aaaataccag ctctacaaga agctaggctc   3960

tgtgacggca tagttttcag tagctttatc acaatattca caatggagaa ttatatgaca   4020

tggtagcaga aataggccct tttatgtgtt gcttctattt tacctcaaat tgtagatata   4080

gggtaatcaa taaaatccat ccatgccttt cacacactaa gt                      4122


<210>  4109
<211>  885
<212>  PRT
<213>  Homo sapiens

<400>  4109

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
465                 470                 475                 480


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
                485                 490                 495


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
            500                 505                 510


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
        515                 520                 525


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
    530                 535                 540


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
545                 550                 555                 560


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
                565                 570                 575


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
            580                 585                 590


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
        595                 600                 605


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
    610                 615                 620


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
625                 630                 635                 640


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
                645                 650                 655


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
            660                 665                 670


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
        675                 680                 685


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
    690                 695                 700


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
705                 710                 715                 720


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
                725                 730                 735


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
            740                 745                 750


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
        755                 760                 765


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
    770                 775                 780


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
785                 790                 795                 800


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
                805                 810                 815


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro 
            820                 825                 830


Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly 
        835                 840                 845


Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala 
    850                 855                 860


Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu 
865                 870                 875                 880


Pro Asp Pro Thr Trp 
                885


<210>  4110
<211>  7138
<212>  DNA
<213>  Homo sapiens

<400>  4110
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gtcaaagaag attggaatgt   1980

cagaattacc aagctacgga agcaagtgga agagattttt aatttgaaat ttgctcaagc   2040

tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt   2100

cttgaaagga tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa acctgaacta   2160

gttatttcct acttgcctcc tgggatggct agtaaaataa acactaaagc tttgcagtcc   2220

cccaaaagac cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg   2280

gaaggcccta ataacaacaa tcctcaaacc tcagctgttc gaaccccgac ccagactaac   2340

ggttctaacg ttcccttcaa gccacgaggg agagagtttt cctttgaggc ctggaatgcc   2400

aaaatcacgg acctaaaaca gaaagttgaa aatctcttca atgagaaatg tggggaagct   2460

cttggcctta aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac   2520

ttttatgtgg aaggcttacc tgagggtgtg ccattccgaa gaccatcgac ttttggcatt   2580

ccgaggctgg agaagatact cagaaacaaa gccaaaatta agttcatcat taaaaagccc   2640

gaaatgtttg agacggcgat taaggagagc acctcctcta agagccctcc cagaaaaata   2700

aattcatcac ccaatgttaa tactactgca tcaggtgttg aagaccttaa catcattcag   2760

gtgacaattc cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta   2820

agagaacaag tgaatgacct ctttagtcgg aaatttggtg aagctattgg tatgggtttt   2880

cctgtgaaag ttccctacag gaaaatcaca attaaccctg gctgtgtggt ggttgatggc   2940

atgcccccgg gggtgtcctt caaagccccc agctacctgg aaatcagctc catgagaagg   3000

atcttagact ctgccgagtt tatcaaattc acggtcatta ggtaagtgag agtttcctgc   3060

ttagtcacag gagcgaatct ggagctcatg aggctgactc ttctaaaatg cagccacagg   3120

tagtcatcga atccggcttc ctatgctgtg caatcaacaa atcaaaataa cttgtgtcat   3180

cattagaatg tcagatgtgc ttctacgaac taagctgact cttttaattc tttggcaaag   3240

ggttggcaaa ctaggactgt ttgccaaatt caggctgcct cctattttta gagtcttcct   3300

gaaacacagc tacacccgta ttatccatgg ctgctttcct gtcacagtga gtaagtagct   3360

gggactgaga aggcatggcc tccaaagtct aaaatattta ctctctagca ctttgtagaa   3420

aaaccttagc taggcacagt ggctaacgcc tgtaatccca gcattttggg aggccaaggc   3480

aggcagatca cctgaggtca ggagttccag accagcctgg ccaacatggt gaaatcccat   3540

ctctacaaaa ataaaacagt tagctgggca tgatggcggg tgcctgtaat cccagctact   3600

cgggaggctg aggcaggata gtcgcttgaa cccaggaggt ggaggttgca atgagccaag   3660

atcatgccac tgcactccag cctggacgac agagtgagac tccatcacaa gaaaaaaaga   3720

actttgtcaa cctctgtctt agggcgcctt gtcacaggct tcgggtcaga cggattcaac   3780

cttgcatcag ccatttgtta gccaggtcac tctgttcttt gtctgtaaat gagattgatc   3840

gttgttccca ctgagagtgt cagctccttc ccgtagagca ggcatgatga ttgtactcac   3900

ctctgacacc attgtgagtg ccacattcct tcccacgtcc ttgtcactgt aagagatgcc   3960

cacctgagca ccaaccccag gttatcttcc cctttgtctt ccagcccccc agaaacagct   4020

acgactcaac ctacccaatc atttcatcat cagattgcca ctgtctctag ttcaggtctc   4080

ttgggactgg cactcagaaa tctcataata aatcctcttg aggcttctca tacactcgtc   4140

ttcttccaat cttctttccc tcaaaatctc atattttggt tccacttcac ccaccgtcat   4200

tctccatatc actcccagga gttaggcaaa aagccccttc cgttcttccg tatgttaaac   4260

ttagaatcac tctgttccct gctctgcgtt tctatttttt gtttttcctc catttactag   4320

tagcttaaca ctttctaaca gtgttcttat tattgatacg tatctatctc ttccataagc   4380

ttataaggtc acggataata cttctcattg tagtacgtaa atgacgtggg ctagatatga   4440

gttgaataaa cagttatacc tgtaaattct tacagagtga aaataaattg ttatacttta   4500

caatttgttt ctctctttag accatttcca ggacttgtga ttaataaccg tgagtatttt   4560

gtgaagtgtt ttgtttttgt tttttcctgg ggtctgacgt gtgtgcgtgt gagtgtgtat   4620

acatgcttaa cgtatatcac gttacttcac ctatgtcagt aaccaggcca aatacttgtt   4680

ttagccctca gtaaaaacac caggcacttc ctagttgtaa aattattcaa gcttcttaac   4740

ttcctatcct cgatgcactt aatcataaaa tggtaataat agcaccgatt ttgggggagt   4800

cgttccagta gatggaaagc atctggaaca ggtgtcagca agctcctgcc gacgtgtatg   4860

cataaagttt tattgaaacc accatcgtgt ccatttgttt atggcagaac tgagagatgg   4920

cagcagcaag tgtgtgcctg caaaacctaa aatatttact aattggctct gcaagaaaag   4980

agtttgcatc cccctaacct agaacagtgt ctagcctcta gtatgtgttt agcctacagt   5040

atgtgctcag cgaatacaat ctatatttat tactgctttt atgactgtta taattactgt   5100

gcttggattt cgttacaaag taagtcacaa tgtgcctgct tctgttagta tttcagcaca   5160

gtgcctggca cacatggggc tctcaaatat tgctgagcga gtgaacaaat gtcctttcaa   5220

ttccttaacg ttgatgtcat tttcaatagt attttgagcc aaacttaatt ttgcgagtgt   5280

gttttgtttt cttaacttta ttattaaaaa tgtataaaag tgaggccagg cgtggtggct   5340

cacgcctgta atcccagcag tttgggaggc tgaggcaggc ggatcagttg aggttgggag   5400

ttggagacca gcccgtccaa catggtgaaa gcctgtctct actaaaaata caaaaatcag   5460

ctgggtgtgg tggcgcgtgc ctgtaatccc agctactcag gaggctgagg caggagagtt   5520

gcttgaatcc tagaggtgga ggttgcagtg agctgagatc gtgccattgc actccagcct   5580

gggcaacaag agcaaaactc tgtcccaata aataaataaa taaaatgttc tcttttgttc   5640

ctgttcttgt gcggtagtgt ggtatagagt tttatggtaa ttactgtgaa ttagtgattc   5700

tgagggacat atcagaactc tgaggtttgt ttccttctca tcttgaggga aacagcaaat   5760

gtatgttaaa atgcttttcc aagggaacaa cacatcctta cattatttaa accaatctgc   5820

ttcattttca gagctggttg atcagagtga gtcagaaggc cccgtgatac aagaatcagc   5880

tgaaccaagc cagttggaag ttccagccac agaagaaata aaagagactg atggaagctc   5940

tcagatcaag caagaaccag accccacgtg gtagacctct tccctcctag gcttaaagta   6000

tcagtggttg agaagagctt ttcggacctg ttactacccc aagctgtgta atatacttgt   6060

ataacagaaa taccttctat acaaaccttt ttttctactt ttagatagaa atgtctactt   6120

tttcagcagt tctgtgaatt aaagagcaga gtgactgtgg gtctggaatg gctggtgtac   6180

ttgggaatgt actatcagga ttttacagca atgctgggaa atgacaggga aaatgacagg   6240

aatgaatctc accagatttt ttatgtactc agcagagcct tgagttacgg tgtttatttt   6300

ccaatcaagt gaagatatct cctacttctc ctactggaac atctcagctt ctgcagtgaa   6360

gaaaaattcc tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa aaaatcattt   6420

aaatgatcct ttgttcacgg ctctccttaa tgactgagtg aacagttcct atctgtatat   6480

ttgactaaac cttttcctaa gctatctctc atggttccta tgttttttta tcataattaa   6540

aagcaaaacc atctggatca cctaacagtc agaggtcagt atctcagcgt gtgaattata   6600

gaggaaatac agagagaacc tcttccactt ttacttttcg tccaaataaa atgcatggtg   6660

taccagaagt tgaagatcgg gttgaggatt ggggctagct cgatgacact aaggccccaa   6720

catcgcggga cctgctgtgg cgcggattct taggaacgct gttctagccg gccccctctc   6780

caggggtcgc cgtggccggc attatttcct agttcttctt gtaaccctga ggtgccagcg   6840

cggggagtga ggaggggtca gggggctaag gatgcaacct ctgacgttct gcgccttcct   6900

aggagagtct tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa taccagctct   6960

acaagaagct aggctctgtg acggcatagt tttcagtagc tttatcacaa tattcacaat   7020

ggagaattat atgacatggt agcagaaata ggccctttta tgtgttgctt ctattttacc   7080

tcaaattgta gatatagggt aatcaataaa atccatccat gcctttcaca cactaagt     7138


<210>  4111
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  4111

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys 
                565                 570                 575


Asn Leu Asn 



<210>  4112
<211>  4282
<212>  DNA
<213>  Homo sapiens

<400>  4112
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagc   2100

tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc   2160

ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc ctacctggtt   2220

tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa   2280

aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa taaacactaa   2340

agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg ttcctgaaat   2400

tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg ttcgaacccc   2460

gacccagact aacggttcta acgttccctt caagccacga gggagagagt tttcctttga   2520

ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct tcaatgagaa   2580

atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc   2640

tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc gaagaccatc   2700

gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa ttaagttcat   2760

cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct ctaagagccc   2820

tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg ttgaagacct   2880

taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga aagttgaaaa   2940

agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg gtgaagctat   3000

tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc ctggctgtgt   3060

ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc tggaaatcag   3120

ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca ttagaccatt   3180

tccaggactt gtgattaata accagctggt tgatcagagt gagtcagaag gccccgtgat   3240

acaagaatca gctgaaccaa gccagttgga agttccagcc acagaagaaa taaaagagac   3300

tgatggaagc tctcagatca agcaagaacc agaccccacg tggtagacct cttccctcct   3360

aggcttaaag tatcagtggt tgagaagagc ttttcggacc tgttactacc ccaagctgta   3420

gccttgagtt acggtgttta ttttccaatc aagtgaagat atctcctact tctcctactg   3480

gaacatctca gcttctgcag tgaagaaaaa ttcctgtgat agttcagttc tttagttttt   3540

ctatttgaaa aaaaaaaatc atttaaatga tcctttgttc acggctctcc ttaatgactg   3600

agtgaacagt tcctatctgt atatttgact aaaccttttc ctaagctatc tctcatggtt   3660

cctatgtttt tttatcataa ttaaaagcaa aaccatctgg atcacctaac agtcagaggt   3720

cagtatctca gcgtgtgaat tatagaggaa atacagagag aacctcttcc acttttactt   3780

ttcgtccaaa taaaatgcat ggtgtaccag aagttgaaga tcgggttgag gattggggct   3840

agctcgatga cactaaggcc ccaacatcgc gggacctgct gtggcgcgga ttcttaggaa   3900

cgctgttcta gccggccccc tctccagggg tcgccgtggc cggcattatt tcctagttct   3960

tcttgtaacc ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc taaggatgca   4020

acctctgacg ttctgcgcct tcctaggaga gtcttacatg tgttgagatt tcacaagcaa   4080

tgcgagttgt aaaataccag ctctacaaga agctaggctc tgtgacggca tagttttcag   4140

tagctttatc acaatattca caatggagaa ttatatgaca tggtagcaga aataggccct   4200

tttatgtgtt gcttctattt tacctcaaat tgtagatata gggtaatcaa taaaatccat   4260

ccatgccttt cacacactaa gt                                            4282


<210>  4113
<211>  974
<212>  PRT
<213>  Homo sapiens

<400>  4113

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala 
545                 550                 555                 560


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
                565                 570                 575


Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile 
            580                 585                 590


Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile 
        595                 600                 605


Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu 
    610                 615                 620


Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys 
625                 630                 635                 640


Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys 
                645                 650                 655


Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro 
            660                 665                 670


Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val 
        675                 680                 685


Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala 
    690                 695                 700


Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys 
705                 710                 715                 720


Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala 
                725                 730                 735


Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu 
            740                 745                 750


Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu 
        755                 760                 765


Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro 
    770                 775                 780


Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro 
785                 790                 795                 800


Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly 
                805                 810                 815


Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn 
            820                 825                 830


Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val 
        835                 840                 845


Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe 
    850                 855                 860


Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val 
865                 870                 875                 880


Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr 
                885                 890                 895


Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile 
            900                 905                 910


Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln 
        915                 920                 925


Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala 
    930                 935                 940


Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr 
945                 950                 955                 960


Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
                965                 970


<210>  4114
<211>  5214
<212>  DNA
<213>  Homo sapiens

<400>  4114
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2040

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2100

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2160

tgaatcaaac ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag   2220

ccctacctgg tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa   2280

gttcgttgtt aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa   2340

aataaacact aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa   2400

ggttcctgaa attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc   2460

tgttcgaacc ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga   2520

gttttccttt gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct   2580

cttcaatgag aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc   2640

gttatttgag tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt   2700

ccgaagacca tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa   2760

aattaagttc atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc   2820

ctctaagagc cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg   2880

tgttgaagac cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc   2940

gaaagttgaa aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt   3000

tggtgaagct attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa   3060

ccctggctgt gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta   3120

cctggaaatc agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt   3180

cattagacca tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga   3240

aggccccgtg atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga   3300

aataaaagag actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac   3360

ctcttccctc ctagggtaaa tcagcttctg tgtcagggat gctgtgtggt gtccatctga   3420

accccctgca tacgcgtagc taatgtgatc tccccacttt cacataagat ggtggccctg   3480

ccttcaggga atgtgggagc caggtgggag ccttcccgga tatttaagct agaagattct   3540

acagggagat tctccttgga tcaatatatg tctctcagtc aaagatgtaa aagcactttt   3600

gccttaaaaa gaatgttctg tttctaaata gagtcaacgt tgtcctcctc attggaattc   3660

actatgagtc agaatcatta gactgacttt tttttttcca tagtaatagt attttgcaga   3720

gtctcacaga gctgcagatc ttttgttcat cttgcagagt taacaagtct gatcctgtta   3780

gtccagattt cttaaatttg gccaagttat aataggagca gtagcttgag acccgaagtc   3840

aggaaacttt gacaatggat tttttttttt aatccagaga cttgtactgg aatttgcctt   3900

accctgtcag ctcatggact taaggtttca tcccgcttta tgagtgcttc tgaatccaag   3960

tcattgttac ctgaatttgc aaattaagtt gtgatattcg tgactgttaa attcctgtaa   4020

ttagattaac ctctttgctt gcttgtttgt tttctctcct attttagctt aaagtatcag   4080

tggttgagaa gagcttttcg gacctgttac taccccaagc tgtgtaatat acttgtataa   4140

cagaaatacc ttctatacaa accttttttt ctacttttag atagaaatgt ctactttttc   4200

agcagttctg tgaattaaag agcagagtga ctgtgggtct ggaatggctg gtgtacttgg   4260

gaatgtacta tcaggatttt acagcaatgc tgggaaatga cagggaaaat gacaggaatg   4320

aatctcacca gattttttat gtactcagca gagccttgag ttacggtgtt tattttccaa   4380

tcaagtgaag atatctccta cttctcctac tggaacatct cagcttctgc agtgaagaaa   4440

aattcctgtg atagttcagt tctttagttt ttctatttga aaaaaaaaaa tcatttaaat   4500

gatcctttgt tcacggctct ccttaatgac tgagtgaaca gttcctatct gtatatttga   4560

ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt tttttatcat aattaaaagc   4620

aaaaccatct ggatcaccta acagtcagag gtcagtatct cagcgtgtga attatagagg   4680

aaatacagag agaacctctt ccacttttac ttttcgtcca aataaaatgc atggtgtacc   4740

agaagttgaa gatcgggttg aggattgggg ctagctcgat gacactaagg ccccaacatc   4800

gcgggacctg ctgtggcgcg gattcttagg aacgctgttc tagccggccc cctctccagg   4860

ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa ccctgaggtg ccagcgcggg   4920

gagtgaggag gggtcagggg gctaaggatg caacctctga cgttctgcgc cttcctagga   4980

gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc agctctacaa   5040

gaagctaggc tctgtgacgg catagttttc agtagcttta tcacaatatt cacaatggag   5100

aattatatga catggtagca gaaataggcc cttttatgtg ttgcttctat tttacctcaa   5160

attgtagata tagggtaatc aataaaatcc atccatgcct ttcacacact aagt         5214


<210>  4115
<211>  978
<212>  PRT
<213>  Homo sapiens

<400>  4115

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu 
            580                 585                 590


Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg 
        595                 600                 605


Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys 
    610                 615                 620


Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys 
625                 630                 635                 640


Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly 
                645                 650                 655


Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn 
            660                 665                 670


Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn 
        675                 680                 685


Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu 
    690                 695                 700


Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu 
705                 710                 715                 720


Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys 
                725                 730                 735


Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu 
            740                 745                 750


Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile 
        755                 760                 765


Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile 
    770                 775                 780


Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser 
785                 790                 795                 800


Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr 
                805                 810                 815


Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro 
            820                 825                 830


Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu 
        835                 840                 845


Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile 
    850                 855                 860


Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn 
865                 870                 875                 880


Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys 
                885                 890                 895


Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser 
            900                 905                 910


Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val 
        915                 920                 925


Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile 
    930                 935                 940


Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu 
945                 950                 955                 960


Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro 
                965                 970                 975


Thr Trp 



<210>  4116
<211>  7213
<212>  DNA
<213>  Homo sapiens

<400>  4116
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   2040

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2100

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2160

atcaaacccg gagttcttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2220

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2280

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2340

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2400

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2460

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2520

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2580

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2640

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2700

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2760

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2820

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2880

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2940

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   3000

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3060

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattaggtaa   3120

gtgagagttt cctgcttagt cacaggagcg aatctggagc tcatgaggct gactcttcta   3180

aaatgcagcc acaggtagtc atcgaatccg gcttcctatg ctgtgcaatc aacaaatcaa   3240

aataacttgt gtcatcatta gaatgtcaga tgtgcttcta cgaactaagc tgactctttt   3300

aattctttgg caaagggttg gcaaactagg actgtttgcc aaattcaggc tgcctcctat   3360

ttttagagtc ttcctgaaac acagctacac ccgtattatc catggctgct ttcctgtcac   3420

agtgagtaag tagctgggac tgagaaggca tggcctccaa agtctaaaat atttactctc   3480

tagcactttg tagaaaaacc ttagctaggc acagtggcta acgcctgtaa tcccagcatt   3540

ttgggaggcc aaggcaggca gatcacctga ggtcaggagt tccagaccag cctggccaac   3600

atggtgaaat cccatctcta caaaaataaa acagttagct gggcatgatg gcgggtgcct   3660

gtaatcccag ctactcggga ggctgaggca ggatagtcgc ttgaacccag gaggtggagg   3720

ttgcaatgag ccaagatcat gccactgcac tccagcctgg acgacagagt gagactccat   3780

cacaagaaaa aaagaacttt gtcaacctct gtcttagggc gccttgtcac aggcttcggg   3840

tcagacggat tcaaccttgc atcagccatt tgttagccag gtcactctgt tctttgtctg   3900

taaatgagat tgatcgttgt tcccactgag agtgtcagct ccttcccgta gagcaggcat   3960

gatgattgta ctcacctctg acaccattgt gagtgccaca ttccttccca cgtccttgtc   4020

actgtaagag atgcccacct gagcaccaac cccaggttat cttccccttt gtcttccagc   4080

cccccagaaa cagctacgac tcaacctacc caatcatttc atcatcagat tgccactgtc   4140

tctagttcag gtctcttggg actggcactc agaaatctca taataaatcc tcttgaggct   4200

tctcatacac tcgtcttctt ccaatcttct ttccctcaaa atctcatatt ttggttccac   4260

ttcacccacc gtcattctcc atatcactcc caggagttag gcaaaaagcc ccttccgttc   4320

ttccgtatgt taaacttaga atcactctgt tccctgctct gcgtttctat tttttgtttt   4380

tcctccattt actagtagct taacactttc taacagtgtt cttattattg atacgtatct   4440

atctcttcca taagcttata aggtcacgga taatacttct cattgtagta cgtaaatgac   4500

gtgggctaga tatgagttga ataaacagtt atacctgtaa attcttacag agtgaaaata   4560

aattgttata ctttacaatt tgtttctctc tttagaccat ttccaggact tgtgattaat   4620

aaccgtgagt attttgtgaa gtgttttgtt tttgtttttt cctggggtct gacgtgtgtg   4680

cgtgtgagtg tgtatacatg cttaacgtat atcacgttac ttcacctatg tcagtaacca   4740

ggccaaatac ttgttttagc cctcagtaaa aacaccaggc acttcctagt tgtaaaatta   4800

ttcaagcttc ttaacttcct atcctcgatg cacttaatca taaaatggta ataatagcac   4860

cgattttggg ggagtcgttc cagtagatgg aaagcatctg gaacaggtgt cagcaagctc   4920

ctgccgacgt gtatgcataa agttttattg aaaccaccat cgtgtccatt tgtttatggc   4980

agaactgaga gatggcagca gcaagtgtgt gcctgcaaaa cctaaaatat ttactaattg   5040

gctctgcaag aaaagagttt gcatccccct aacctagaac agtgtctagc ctctagtatg   5100

tgtttagcct acagtatgtg ctcagcgaat acaatctata tttattactg cttttatgac   5160

tgttataatt actgtgcttg gatttcgtta caaagtaagt cacaatgtgc ctgcttctgt   5220

tagtatttca gcacagtgcc tggcacacat ggggctctca aatattgctg agcgagtgaa   5280

caaatgtcct ttcaattcct taacgttgat gtcattttca atagtatttt gagccaaact   5340

taattttgcg agtgtgtttt gttttcttaa ctttattatt aaaaatgtat aaaagtgagg   5400

ccaggcgtgg tggctcacgc ctgtaatccc agcagtttgg gaggctgagg caggcggatc   5460

agttgaggtt gggagttgga gaccagcccg tccaacatgg tgaaagcctg tctctactaa   5520

aaatacaaaa atcagctggg tgtggtggcg cgtgcctgta atcccagcta ctcaggaggc   5580

tgaggcagga gagttgcttg aatcctagag gtggaggttg cagtgagctg agatcgtgcc   5640

attgcactcc agcctgggca acaagagcaa aactctgtcc caataaataa ataaataaaa   5700

tgttctcttt tgttcctgtt cttgtgcggt agtgtggtat agagttttat ggtaattact   5760

gtgaattagt gattctgagg gacatatcag aactctgagg tttgtttcct tctcatcttg   5820

agggaaacag caaatgtatg ttaaaatgct tttccaaggg aacaacacat ccttacatta   5880

tttaaaccaa tctgcttcat tttcagagct ggttgatcag agtgagtcag aaggccccgt   5940

gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag aaataaaaga   6000

gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga cctcttccct   6060

cctaggctta aagtatcagt ggttgagaag agcttttcgg acctgttact accccaagct   6120

gtgtaatata cttgtataac agaaatacct tctatacaaa cctttttttc tacttttaga   6180

tagaaatgtc tactttttca gcagttctgt gaattaaaga gcagagtgac tgtgggtctg   6240

gaatggctgg tgtacttggg aatgtactat caggatttta cagcaatgct gggaaatgac   6300

agggaaaatg acaggaatga atctcaccag attttttatg tactcagcag agccttgagt   6360

tacggtgttt attttccaat caagtgaaga tatctcctac ttctcctact ggaacatctc   6420

agcttctgca gtgaagaaaa attcctgtga tagttcagtt ctttagtttt tctatttgaa   6480

aaaaaaaaat catttaaatg atcctttgtt cacggctctc cttaatgact gagtgaacag   6540

ttcctatctg tatatttgac taaacctttt cctaagctat ctctcatggt tcctatgttt   6600

ttttatcata attaaaagca aaaccatctg gatcacctaa cagtcagagg tcagtatctc   6660

agcgtgtgaa ttatagagga aatacagaga gaacctcttc cacttttact tttcgtccaa   6720

ataaaatgca tggtgtacca gaagttgaag atcgggttga ggattggggc tagctcgatg   6780

acactaaggc cccaacatcg cgggacctgc tgtggcgcgg attcttagga acgctgttct   6840

agccggcccc ctctccaggg gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac   6900

cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc aacctctgac   6960

gttctgcgcc ttcctaggag agtcttacat gtgttgagat ttcacaagca atgcgagttg   7020

taaaatacca gctctacaag aagctaggct ctgtgacggc atagttttca gtagctttat   7080

cacaatattc acaatggaga attatatgac atggtagcag aaataggccc ttttatgtgt   7140

tgcttctatt ttacctcaaa ttgtagatat agggtaatca ataaaatcca tccatgcctt   7200

tcacacacta agt                                                      7213


<210>  4117
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  4117

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
                565                 570                 575


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly 
            580                 585                 590


Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600


<210>  4118
<211>  3854
<212>  DNA
<213>  Homo sapiens

<400>  4118
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   2040

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   2100

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2160

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2220

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2280

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2340

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2400

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2460

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2520

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2580

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2640

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2700

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2760

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2820

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2880

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2940

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   3000

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   3060

cggtcattag accatttcca ggacttgtga ttaataacca gctggttgat cagagtgagt   3120

cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt ccagccacag   3180

aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac cccacgtggt   3240

agacctcttc cctcctaggc aaaaccatct ggatcaccta acagtcagag gtcagtatct   3300

cagcgtgtga attatagagg aaatacagag agaacctctt ccacttttac ttttcgtcca   3360

aataaaatgc atggtgtacc agaagttgaa gatcgggttg aggattgggg ctagctcgat   3420

gacactaagg ccccaacatc gcgggacctg ctgtggcgcg gattcttagg aacgctgttc   3480

tagccggccc cctctccagg ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa   3540

ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg gctaaggatg caacctctga   3600

cgttctgcgc cttcctagga gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt   3660

gtaaaatacc agctctacaa gaagctaggc tctgtgacgg catagttttc agtagcttta   3720

tcacaatatt cacaatggag aattatatga catggtagca gaaataggcc cttttatgtg   3780

ttgcttctat tttacctcaa attgtagata tagggtaatc aataaaatcc atccatgcct   3840

ttcacacact aagt                                                     3854


<210>  4119
<211>  885
<212>  PRT
<213>  Homo sapiens

<400>  4119

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
465                 470                 475                 480


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
                485                 490                 495


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
            500                 505                 510


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
        515                 520                 525


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
    530                 535                 540


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
545                 550                 555                 560


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
                565                 570                 575


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
            580                 585                 590


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
        595                 600                 605


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
    610                 615                 620


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
625                 630                 635                 640


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
                645                 650                 655


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
            660                 665                 670


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
        675                 680                 685


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
    690                 695                 700


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
705                 710                 715                 720


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
                725                 730                 735


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
            740                 745                 750


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
        755                 760                 765


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
    770                 775                 780


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
785                 790                 795                 800


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
                805                 810                 815


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro 
            820                 825                 830


Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly 
        835                 840                 845


Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala 
    850                 855                 860


Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu 
865                 870                 875                 880


Pro Asp Pro Thr Trp 
                885


<210>  4120
<211>  4938
<212>  DNA
<213>  Homo sapiens

<400>  4120
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gtcaaagaag attggaatgt cagaattacc aagctacgga   1920

agcaagtgga agagattttt aatttgaaat ttgctcaagc tcttggactc accgaggcag   1980

taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgaaagga tcgtccgcgg   2040

gagtaataaa atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc   2100

tgggatggct agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc   2160

tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa   2220

tcctcaaacc tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa   2280

gccacgaggg agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca   2340

gaaagttgaa aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt   2400

gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc   2460

tgagggtgtg ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact   2520

cagaaacaaa gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat   2580

taaggagagc acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa   2640

tactactgca tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga   2700

taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct   2760

ctttagtcgg aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag   2820

gaaaatcaca attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt   2880

caaagccccc agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt   2940

tatcaaattc acggtcatta gaccatttcc aggacttgtg attaataacc agctggttga   3000

tcagagtgag tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt   3060

tccagccaca gaaggtaaaa ggacctcttc cctcctaggg taaatcagct tctgtgtcag   3120

ggatgctgtg tggtgtccat ctgaaccccc tgcatacgcg tagctaatgt gatctcccca   3180

ctttcacata agatggtggc cctgccttca gggaatgtgg gagccaggtg ggagccttcc   3240

cggatattta agctagaaga ttctacaggg agattctcct tggatcaata tatgtctctc   3300

agtcaaagat gtaaaagcac ttttgcctta aaaagaatgt tctgtttcta aatagagtca   3360

acgttgtcct cctcattgga attcactatg agtcagaatc attagactga cttttttttt   3420

tccatagtaa tagtattttg cagagtctca cagagctgca gatcttttgt tcatcttgca   3480

gagttaacaa gtctgatcct gttagtccag atttcttaaa tttggccaag ttataatagg   3540

agcagtagct tgagacccga agtcaggaaa ctttgacaat ggattttttt ttttaatcca   3600

gagacttgta ctggaatttg ccttaccctg tcagctcatg gacttaaggt ttcatcccgc   3660

tttatgagtg cttctgaatc caagtcattg ttacctgaat ttgcaaatta agttgtgata   3720

ttcgtgactg ttaaattcct gtaattagat taacctcttt gcttgcttgt ttgttttctc   3780

tcctatttta gcttaaagta tcagtggttg agaagagctt ttcggacctg ttactacccc   3840

aagctgtgta atatacttgt ataacagaaa taccttctat acaaaccttt ttttctactt   3900

ttagatagaa atgtctactt tttcagcagt tctgtgaatt aaagagcaga gtgactgtgg   3960

gtctggaatg gctggtgtac ttgggaatgt actatcagga ttttacagca atgctgggaa   4020

atgacaggga aaatgacagg aatgaatctc accagatttt ttatgtactc agcagagcct   4080

tgagttacgg tgtttatttt ccaatcaagt gaagatatct cctacttctc ctactggaac   4140

atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta gtttttctat   4200

ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg ctctccttaa tgactgagtg   4260

aacagttcct atctgtatat ttgactaaac cttttcctaa gctatctctc atggttccta   4320

tgttttttta tcataattaa aagcaaaacc atctggatca cctaacagtc agaggtcagt   4380

atctcagcgt gtgaattata gaggaaatac agagagaacc tcttccactt ttacttttcg   4440

tccaaataaa atgcatggtg taccagaagt tgaagatcgg gttgaggatt ggggctagct   4500

cgatgacact aaggccccaa catcgcggga cctgctgtgg cgcggattct taggaacgct   4560

gttctagccg gccccctctc caggggtcgc cgtggccggc attatttcct agttcttctt   4620

gtaaccctga ggtgccagcg cggggagtga ggaggggtca gggggctaag gatgcaacct   4680

ctgacgttct gcgccttcct aggagagtct tacatgtgtt gagatttcac aagcaatgcg   4740

agttgtaaaa taccagctct acaagaagct aggctctgtg acggcatagt tttcagtagc   4800

tttatcacaa tattcacaat ggagaattat atgacatggt agcagaaata ggccctttta   4860

tgtgttgctt ctattttacc tcaaattgta gatatagggt aatcaataaa atccatccat   4920

gcctttcaca cactaagt                                                 4938


<210>  4121
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  4121

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
                485                 490                 495


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
            500                 505                 510


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
        515                 520                 525


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser 
    530                 535                 540


Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
545                 550                 555


<210>  4122
<211>  3745
<212>  DNA
<213>  Homo sapiens

<400>  4122
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gtcaaagaag attggaatgt cagaattacc aagctacgga   1920

agcaagtgga agagattttt aatttgaaat ttgctcaagc tcttggactc accgaggcag   1980

taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgaaagga tcgtccgcgg   2040

gagtaataaa atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc   2100

tgggatggct agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc   2160

tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa   2220

tcctcaaacc tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa   2280

gccacgaggg agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca   2340

gaaagttgaa aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt   2400

gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc   2460

tgagggtgtg ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact   2520

cagaaacaaa gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat   2580

taaggagagc acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa   2640

tactactgca tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga   2700

taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct   2760

ctttagtcgg aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag   2820

gaaaatcaca attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt   2880

caaagccccc agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt   2940

tatcaaattc acggtcatta gaccatttcc aggacttgtg attaataacc agctggttga   3000

tcagagtgag tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt   3060

tccagccaca gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga   3120

ccccacgtgg tagacctctt ccctcctagg caaaaccatc tggatcacct aacagtcaga   3180

ggtcagtatc tcagcgtgtg aattatagag gaaatacaga gagaacctct tccactttta   3240

cttttcgtcc aaataaaatg catggtgtac cagaagttga agatcgggtt gaggattggg   3300

gctagctcga tgacactaag gccccaacat cgcgggacct gctgtggcgc ggattcttag   3360

gaacgctgtt ctagccggcc ccctctccag gggtcgccgt ggccggcatt atttcctagt   3420

tcttcttgta accctgaggt gccagcgcgg ggagtgagga ggggtcaggg ggctaaggat   3480

gcaacctctg acgttctgcg ccttcctagg agagtcttac atgtgttgag atttcacaag   3540

caatgcgagt tgtaaaatac cagctctaca agaagctagg ctctgtgacg gcatagtttt   3600

cagtagcttt atcacaatat tcacaatgga gaattatatg acatggtagc agaaataggc   3660

ccttttatgt gttgcttcta ttttacctca aattgtagat atagggtaat caataaaatc   3720

catccatgcc tttcacacac taagt                                         3745


<210>  4123
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  4123

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
                485                 490                 495


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
            500                 505                 510


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
        515                 520                 525


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser 
    530                 535                 540


Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
545                 550                 555


<210>  4124
<211>  5136
<212>  DNA
<213>  Homo sapiens

<400>  4124
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gtcaaagaag attggaatgt   1980

cagaattacc aagctacgga agcaagtgga agagattttt aatttgaaat ttgctcaagc   2040

tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt   2100

cttgtatgtg gaaggcttgc cagaggggat tcccttccga agccctacct ggtttggaat   2160

tccacgactt gaaaggatcg tccgcgggag taataaaatc aagttcgttg ttaaaaaacc   2220

tgaactagtt atttcctact tgcctcctgg gatggctagt aaaataaaca ctaaagcttt   2280

gcagtccccc aaaagaccac gaagtcctgg gagtaattca aaggttcctg aaattgaggt   2340

caccgtggaa ggccctaata acaacaatcc tcaaacctca gctgttcgaa ccccgaccca   2400

gactaacggt tctaacgttc ccttcaagcc acgagggaga gagttttcct ttgaggcctg   2460

gaatgccaaa atcacggacc taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg   2520

ggaagctctt ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg agtctttccc   2580

ggaagacttt tatgtggaag gcttacctga gggtgtgcca ttccgaagac catcgacttt   2640

tggcattccg aggctggaga agatactcag aaacaaagcc aaaattaagt tcatcattaa   2700

aaagcccgaa atgtttgaga cggcgattaa ggagagcacc tcctctaaga gccctcccag   2760

aaaaataaat tcatcaccca atgttaatac tactgcatca ggtgttgaag accttaacat   2820

cattcaggtg acaattccag atgatgataa tgaaagactc tcgaaagttg aaaaagctag   2880

acagctaaga gaacaagtga atgacctctt tagtcggaaa tttggtgaag ctattggtat   2940

gggttttcct gtgaaagttc cctacaggaa aatcacaatt aaccctggct gtgtggtggt   3000

tgatggcatg cccccggggg tgtccttcaa agcccccagc tacctggaaa tcagctccat   3060

gagaaggatc ttagactctg ccgagtttat caaattcacg gtcattagac catttccagg   3120

acttgtgatt aataaccagc tggttgatca gagtgagtca gaaggccccg tgatacaaga   3180

atcagctgaa ccaagccagt tggaagttcc agccacagaa gaaataaaag agactgatgg   3240

aagctctcag atcaagcaag aaccagaccc cacgtggtag acctcttccc tcctagggta   3300

aatcagcttc tgtgtcaggg atgctgtgtg gtgtccatct gaaccccctg catacgcgta   3360

gctaatgtga tctccccact ttcacataag atggtggccc tgccttcagg gaatgtggga   3420

gccaggtggg agccttcccg gatatttaag ctagaagatt ctacagggag attctccttg   3480

gatcaatata tgtctctcag tcaaagatgt aaaagcactt ttgccttaaa aagaatgttc   3540

tgtttctaaa tagagtcaac gttgtcctcc tcattggaat tcactatgag tcagaatcat   3600

tagactgact tttttttttc catagtaata gtattttgca gagtctcaca gagctgcaga   3660

tcttttgttc atcttgcaga gttaacaagt ctgatcctgt tagtccagat ttcttaaatt   3720

tggccaagtt ataataggag cagtagcttg agacccgaag tcaggaaact ttgacaatgg   3780

attttttttt ttaatccaga gacttgtact ggaatttgcc ttaccctgtc agctcatgga   3840

cttaaggttt catcccgctt tatgagtgct tctgaatcca agtcattgtt acctgaattt   3900

gcaaattaag ttgtgatatt cgtgactgtt aaattcctgt aattagatta acctctttgc   3960

ttgcttgttt gttttctctc ctattttagc ttaaagtatc agtggttgag aagagctttt   4020

cggacctgtt actaccccaa gctgtgtaat atacttgtat aacagaaata ccttctatac   4080

aaaccttttt ttctactttt agatagaaat gtctactttt tcagcagttc tgtgaattaa   4140

agagcagagt gactgtgggt ctggaatggc tggtgtactt gggaatgtac tatcaggatt   4200

ttacagcaat gctgggaaat gacagggaaa atgacaggaa tgaatctcac cagatttttt   4260

atgtactcag cagagccttg agttacggtg tttattttcc aatcaagtga agatatctcc   4320

tacttctcct actggaacat ctcagcttct gcagtgaaga aaaattcctg tgatagttca   4380

gttctttagt ttttctattt gaaaaaaaaa aatcatttaa atgatccttt gttcacggct   4440

ctccttaatg actgagtgaa cagttcctat ctgtatattt gactaaacct tttcctaagc   4500

tatctctcat ggttcctatg tttttttatc ataattaaaa gcaaaaccat ctggatcacc   4560

taacagtcag aggtcagtat ctcagcgtgt gaattataga ggaaatacag agagaacctc   4620

ttccactttt acttttcgtc caaataaaat gcatggtgta ccagaagttg aagatcgggt   4680

tgaggattgg ggctagctcg atgacactaa ggccccaaca tcgcgggacc tgctgtggcg   4740

cggattctta ggaacgctgt tctagccggc cccctctcca ggggtcgccg tggccggcat   4800

tatttcctag ttcttcttgt aaccctgagg tgccagcgcg gggagtgagg aggggtcagg   4860

gggctaagga tgcaacctct gacgttctgc gccttcctag gagagtctta catgtgttga   4920

gatttcacaa gcaatgcgag ttgtaaaata ccagctctac aagaagctag gctctgtgac   4980

ggcatagttt tcagtagctt tatcacaata ttcacaatgg agaattatat gacatggtag   5040

cagaaatagg cccttttatg tgttgcttct attttacctc aaattgtaga tatagggtaa   5100

tcaataaaat ccatccatgc ctttcacaca ctaagt                             5136


<210>  4125
<211>  952
<212>  PRT
<213>  Homo sapiens

<400>  4125

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr 
                565                 570                 575


Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys 
            580                 585                 590


Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro 
        595                 600                 605


Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys 
    610                 615                 620


Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val 
625                 630                 635                 640


Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg 
                645                 650                 655


Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly 
            660                 665                 670


Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys 
        675                 680                 685


Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly 
    690                 695                 700


Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro 
705                 710                 715                 720


Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg 
                725                 730                 735


Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys 
            740                 745                 750


Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala 
        755                 760                 765


Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser 
    770                 775                 780


Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile 
785                 790                 795                 800


Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val 
                805                 810                 815


Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg 
            820                 825                 830


Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr 
        835                 840                 845


Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro 
    850                 855                 860


Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met 
865                 870                 875                 880


Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
                885                 890                 895


Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu 
            900                 905                 910


Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu 
        915                 920                 925


Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile 
    930                 935                 940


Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  4126
<211>  4131
<212>  DNA
<213>  Homo sapiens

<400>  4126
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1980

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   2040

catatcctgt gtttgaatca aacccggagt tcttgtatgt ggaaggcttg ccagagggga   2100

ttcccttccg aagccctacc tggtttggaa ttccacgact tgaaaggatc gtccgcggga   2160

gtaataaaat caagttcgtt gttaaaaaac ctgaactagt tatttcctac ttgcctcctg   2220

ggatggctag taaaataaac actaaagctt tgcagtcccc caaaagacca cgaagtcctg   2280

ggagtaattc aaaggttcct gaaattgagg tcaccgtgga aggccctaat aacaacaatc   2340

ctcaaacctc agctgttcga accccgaccc agactaacgg ttctaacgtt cccttcaagc   2400

cacgagggag agagttttcc tttgaggcct ggaatgccaa aatcacggac ctaaaacaga   2460

aagttgaaaa tctcttcaat gagaaatgtg gggaagctct tggccttaaa caagctgtga   2520

aggtgccgtt cgcgttattt gagtctttcc cggaagactt ttatgtggaa ggcttacctg   2580

agggtgtgcc attccgaaga ccatcgactt ttggcattcc gaggctggag aagatactca   2640

gaaacaaagc caaaattaag ttcatcatta aaaagcccga aatgtttgag acggcgatta   2700

aggagagcac ctcctctaag agccctccca gaaaaataaa ttcatcaccc aatgttaata   2760

ctactgcatc aggtgttgaa gaccttaaca tcattcaggt gacaattcca gatgatgata   2820

atgaaagact ctcgaaagtt gaaaaagcta gacagctaag agaacaagtg aatgacctct   2880

ttagtcggaa atttggtgaa gctattggta tgggttttcc tgtgaaagtt ccctacagga   2940

aaatcacaat taaccctggc tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca   3000

aagcccccag ctacctggaa atcagctcca tgagaaggat cttagactct gccgagttta   3060

tcaaattcac ggtcattaga ccatttccag gacttgtgat taataaccag ctggttgatc   3120

agagtgagtc agaaggcccc gtgatacaag aatcagctga accaagccag ttggaagttc   3180

cagccacaga agaaataaaa gagactgatg gaagctctca gatcaagcaa gaaccagacc   3240

ccacgtggta gacctcttcc ctcctaggag ccttgagtta cggtgtttat tttccaatca   3300

agtgaagata tctcctactt ctcctactgg aacatctcag cttctgcagt gaagaaaaat   3360

tcctgtgata gttcagttct ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat   3420

cctttgttca cggctctcct taatgactga gtgaacagtt cctatctgta tatttgacta   3480

aaccttttcc taagctatct ctcatggttc ctatgttttt ttatcataat taaaagcaaa   3540

accatctgga tcacctaaca gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa   3600

tacagagaga acctcttcca cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga   3660

agttgaagat cgggttgagg attggggcta gctcgatgac actaaggccc caacatcgcg   3720

ggacctgctg tggcgcggat tcttaggaac gctgttctag ccggccccct ctccaggggt   3780

cgccgtggcc ggcattattt cctagttctt cttgtaaccc tgaggtgcca gcgcggggag   3840

tgaggagggg tcagggggct aaggatgcaa cctctgacgt tctgcgcctt cctaggagag   3900

tcttacatgt gttgagattt cacaagcaat gcgagttgta aaataccagc tctacaagaa   3960

gctaggctct gtgacggcat agttttcagt agctttatca caatattcac aatggagaat   4020

tatatgacat ggtagcagaa ataggccctt ttatgtgttg cttctatttt acctcaaatt   4080

gtagatatag ggtaatcaat aaaatccatc catgcctttc acacactaag t            4131


<210>  4127
<211>  888
<212>  PRT
<213>  Homo sapiens

<400>  4127

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
    450                 455                 460


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
465                 470                 475                 480


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
                485                 490                 495


Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr 
            500                 505                 510


Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys 
        515                 520                 525


Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro 
    530                 535                 540


Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys 
545                 550                 555                 560


Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val 
                565                 570                 575


Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg 
            580                 585                 590


Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly 
        595                 600                 605


Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys 
    610                 615                 620


Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly 
625                 630                 635                 640


Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro 
                645                 650                 655


Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg 
            660                 665                 670


Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys 
        675                 680                 685


Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala 
    690                 695                 700


Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser 
705                 710                 715                 720


Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile 
                725                 730                 735


Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val 
            740                 745                 750


Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg 
        755                 760                 765


Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr 
    770                 775                 780


Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro 
785                 790                 795                 800


Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met 
                805                 810                 815


Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
            820                 825                 830


Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu 
        835                 840                 845


Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu 
    850                 855                 860


Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile 
865                 870                 875                 880


Lys Gln Glu Pro Asp Pro Thr Trp 
                885


<210>  4128
<211>  3799
<212>  DNA
<213>  Homo sapiens

<400>  4128
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040

taccatatcc tgtgtttgaa tcaaacccgg agttcttgaa aggatcgtcc gcgggagtaa   2100

taaaatcaag ttcgttgtta aaaaacctga actagttatt tcctacttgc ctcctgggat   2160

ggctagtaaa ataaacacta aagctttgca gtcccccaaa agaccacgaa gtcctgggag   2220

taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc cctaataaca acaatcctca   2280

aacctcagct gttcgaaccc cgacccagac taacggttct aacgttccct tcaagccacg   2340

agggagagag ttttcctttg aggcctggaa tgccaaaatc acggacctaa aacagaaagt   2400

tgaaaatctc ttcaatgaga aatgtgggga agctcttggc cttaaacaag ctgtgaaggt   2460

gccgttcgcg ttatttgagt ctttcccgga agacttttat gtggaaggct tacctgaggg   2520

tgtgccattc cgaagaccat cgacttttgg cattccgagg ctggagaaga tactcagaaa   2580

caaagccaaa attaagttca tcattaaaaa gcccgaaatg tttgagacgg cgattaagga   2640

gagcacctcc tctaagagcc ctcccagaaa aataaattca tcacccaatg ttaatactac   2700

tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca attccagatg atgataatga   2760

aagactctcg aaagttgaaa aagctagaca gctaagagaa caagtgaatg acctctttag   2820

tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg aaagttccct acaggaaaat   2880

cacaattaac cctggctgtg tggtggttga tggcatgccc ccgggggtgt ccttcaaagc   2940

ccccagctac ctggaaatca gctccatgag aaggatctta gactctgccg agtttatcaa   3000

attcacggtc attagaccat ttccaggact tgtgattaat aaccagctgg ttgatcagag   3060

tgagtcagaa ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc   3120

cacagaagaa ataaaagaga ctgatggaag ctctcagatc aagcaagaac cagaccccac   3180

gtggtagacc tcttccctcc taggcaaaac catctggatc acctaacagt cagaggtcag   3240

tatctcagcg tgtgaattat agaggaaata cagagagaac ctcttccact tttacttttc   3300

gtccaaataa aatgcatggt gtaccagaag ttgaagatcg ggttgaggat tggggctagc   3360

tcgatgacac taaggcccca acatcgcggg acctgctgtg gcgcggattc ttaggaacgc   3420

tgttctagcc ggccccctct ccaggggtcg ccgtggccgg cattatttcc tagttcttct   3480

tgtaaccctg aggtgccagc gcggggagtg aggaggggtc agggggctaa ggatgcaacc   3540

tctgacgttc tgcgccttcc taggagagtc ttacatgtgt tgagatttca caagcaatgc   3600

gagttgtaaa ataccagctc tacaagaagc taggctctgt gacggcatag ttttcagtag   3660

ctttatcaca atattcacaa tggagaatta tatgacatgg tagcagaaat aggccctttt   3720

atgtgttgct tctattttac ctcaaattgt agatataggg taatcaataa aatccatcca   3780

tgcctttcac acactaagt                                                3799


<210>  4129
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  4129

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
    450                 455                 460


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
465                 470                 475                 480


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
                485                 490                 495


Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu 
            500                 505                 510


Lys Asn Leu Asn 
        515


<210>  4130
<211>  4178
<212>  DNA
<213>  Homo sapiens

<400>  4130
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   2040

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   2100

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2160

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2220

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2280

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2340

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2400

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2460

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2520

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2580

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2640

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2700

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2760

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2820

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2880

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2940

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   3000

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   3060

cggtcattag accatttcca ggacttgtga ttaataacca gctggttgat cagagtgagt   3120

cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt ccagccacag   3180

aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac cccacgtggt   3240

agacctcttc cctcctaggc ttaaagtatc agtggttgag aagagctttt cggacctgtt   3300

actaccccaa gctgtagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct   3360

cctacttctc ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt   3420

cagttcttta gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg   3480

ctctccttaa tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa   3540

gctatctctc atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca   3600

cctaacagtc agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc   3660

tcttccactt ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg   3720

gttgaggatt ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg   3780

cgcggattct taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc   3840

attatttcct agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca   3900

gggggctaag gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt   3960

gagatttcac aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg   4020

acggcatagt tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt   4080

agcagaaata ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt   4140

aatcaataaa atccatccat gcctttcaca cactaagt                           4178


<210>  4131
<211>  885
<212>  PRT
<213>  Homo sapiens

<400>  4131

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
465                 470                 475                 480


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
                485                 490                 495


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
            500                 505                 510


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
        515                 520                 525


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
    530                 535                 540


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
545                 550                 555                 560


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
                565                 570                 575


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
            580                 585                 590


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
        595                 600                 605


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
    610                 615                 620


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
625                 630                 635                 640


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
                645                 650                 655


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
            660                 665                 670


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
        675                 680                 685


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
    690                 695                 700


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
705                 710                 715                 720


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
                725                 730                 735


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
            740                 745                 750


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
        755                 760                 765


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
    770                 775                 780


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
785                 790                 795                 800


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
                805                 810                 815


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro 
            820                 825                 830


Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly 
        835                 840                 845


Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala 
    850                 855                 860


Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu 
865                 870                 875                 880


Pro Asp Pro Thr Trp 
                885


<210>  4132
<211>  7799
<212>  DNA
<213>  Homo sapiens

<400>  4132
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   1980

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   2040

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2100

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2160

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2220

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2280

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2340

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2400

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2460

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2520

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2580

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2640

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2700

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2760

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2820

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2880

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   2940

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   3000

cggtcattag gtaagtgaga gtttcctgct tagtcacagg agcgaatctg gagctcatga   3060

ggctgactct tctaaaatgc agccacaggt agtcatcgaa tccggcttcc tatgctgtgc   3120

aatcaacaaa tcaaaataac ttgtgtcatc attagaatgt cagatgtgct tctacgaact   3180

aagctgactc ttttaattct ttggcaaagg gttggcaaac taggactgtt tgccaaattc   3240

aggctgcctc ctatttttag agtcttcctg aaacacagct acacccgtat tatccatggc   3300

tgctttcctg tcacagtgag taagtagctg ggactgagaa ggcatggcct ccaaagtcta   3360

aaatatttac tctctagcac tttgtagaaa aaccttagct aggcacagtg gctaacgcct   3420

gtaatcccag cattttggga ggccaaggca ggcagatcac ctgaggtcag gagttccaga   3480

ccagcctggc caacatggtg aaatcccatc tctacaaaaa taaaacagtt agctgggcat   3540

gatggcgggt gcctgtaatc ccagctactc gggaggctga ggcaggatag tcgcttgaac   3600

ccaggaggtg gaggttgcaa tgagccaaga tcatgccact gcactccagc ctggacgaca   3660

gagtgagact ccatcacaag aaaaaaagaa ctttgtcaac ctctgtctta gggcgccttg   3720

tcacaggctt cgggtcagac ggattcaacc ttgcatcagc catttgttag ccaggtcact   3780

ctgttctttg tctgtaaatg agattgatcg ttgttcccac tgagagtgtc agctccttcc   3840

cgtagagcag gcatgatgat tgtactcacc tctgacacca ttgtgagtgc cacattcctt   3900

cccacgtcct tgtcactgta agagatgccc acctgagcac caaccccagg ttatcttccc   3960

ctttgtcttc cagcccccca gaaacagcta cgactcaacc tacccaatca tttcatcatc   4020

agattgccac tgtctctagt tcaggtctct tgggactggc actcagaaat ctcataataa   4080

atcctcttga ggcttctcat acactcgtct tcttccaatc ttctttccct caaaatctca   4140

tattttggtt ccacttcacc caccgtcatt ctccatatca ctcccaggag ttaggcaaaa   4200

agccccttcc gttcttccgt atgttaaact tagaatcact ctgttccctg ctctgcgttt   4260

ctattttttg tttttcctcc atttactagt agcttaacac tttctaacag tgttcttatt   4320

attgatacgt atctatctct tccataagct tataaggtca cggataatac ttctcattgt   4380

agtacgtaaa tgacgtgggc tagatatgag ttgaataaac agttatacct gtaaattctt   4440

acagagtgaa aataaattgt tatactttac aatttgtttc tctctttaga ccatttccag   4500

gacttgtgat taataaccgt gagtattttg tgaagtgttt tgtttttgtt ttttcctggg   4560

gtctgacgtg tgtgcgtgtg agtgtgtata catgcttaac gtatatcacg ttacttcacc   4620

tatgtcagta accaggccaa atacttgttt tagccctcag taaaaacacc aggcacttcc   4680

tagttgtaaa attattcaag cttcttaact tcctatcctc gatgcactta atcataaaat   4740

ggtaataata gcaccgattt tgggggagtc gttccagtag atggaaagca tctggaacag   4800

gtgtcagcaa gctcctgccg acgtgtatgc ataaagtttt attgaaacca ccatcgtgtc   4860

catttgttta tggcagaact gagagatggc agcagcaagt gtgtgcctgc aaaacctaaa   4920

atatttacta attggctctg caagaaaaga gtttgcatcc ccctaaccta gaacagtgtc   4980

tagcctctag tatgtgttta gcctacagta tgtgctcagc gaatacaatc tatatttatt   5040

actgctttta tgactgttat aattactgtg cttggatttc gttacaaagt aagtcacaat   5100

gtgcctgctt ctgttagtat ttcagcacag tgcctggcac acatggggct ctcaaatatt   5160

gctgagcgag tgaacaaatg tcctttcaat tccttaacgt tgatgtcatt ttcaatagta   5220

ttttgagcca aacttaattt tgcgagtgtg ttttgttttc ttaactttat tattaaaaat   5280

gtataaaagt gaggccaggc gtggtggctc acgcctgtaa tcccagcagt ttgggaggct   5340

gaggcaggcg gatcagttga ggttgggagt tggagaccag cccgtccaac atggtgaaag   5400

cctgtctcta ctaaaaatac aaaaatcagc tgggtgtggt ggcgcgtgcc tgtaatccca   5460

gctactcagg aggctgaggc aggagagttg cttgaatcct agaggtggag gttgcagtga   5520

gctgagatcg tgccattgca ctccagcctg ggcaacaaga gcaaaactct gtcccaataa   5580

ataaataaat aaaatgttct cttttgttcc tgttcttgtg cggtagtgtg gtatagagtt   5640

ttatggtaat tactgtgaat tagtgattct gagggacata tcagaactct gaggtttgtt   5700

tccttctcat cttgagggaa acagcaaatg tatgttaaaa tgcttttcca agggaacaac   5760

acatccttac attatttaaa ccaatctgct tcattttcag agctggttga tcagagtgag   5820

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   5880

gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga ccccacgtgg   5940

tagacctctt ccctcctagg gtaaatcagc ttctgtgtca gggatgctgt gtggtgtcca   6000

tctgaacccc ctgcatacgc gtagctaatg tgatctcccc actttcacat aagatggtgg   6060

ccctgccttc agggaatgtg ggagccaggt gggagccttc ccggatattt aagctagaag   6120

attctacagg gagattctcc ttggatcaat atatgtctct cagtcaaaga tgtaaaagca   6180

cttttgcctt aaaaagaatg ttctgtttct aaatagagtc aacgttgtcc tcctcattgg   6240

aattcactat gagtcagaat cattagactg actttttttt ttccatagta atagtatttt   6300

gcagagtctc acagagctgc agatcttttg ttcatcttgc agagttaaca agtctgatcc   6360

tgttagtcca gatttcttaa atttggccaa gttataatag gagcagtagc ttgagacccg   6420

aagtcaggaa actttgacaa tggatttttt tttttaatcc agagacttgt actggaattt   6480

gccttaccct gtcagctcat ggacttaagg tttcatcccg ctttatgagt gcttctgaat   6540

ccaagtcatt gttacctgaa tttgcaaatt aagttgtgat attcgtgact gttaaattcc   6600

tgtaattaga ttaacctctt tgcttgcttg tttgttttct ctcctatttt agcttaaagt   6660

atcagtggtt gagaagagct tttcggacct gttactaccc caagctgtgt aatatacttg   6720

tataacagaa ataccttcta tacaaacctt tttttctact tttagataga aatgtctact   6780

ttttcagcag ttctgtgaat taaagagcag agtgactgtg ggtctggaat ggctggtgta   6840

cttgggaatg tactatcagg attttacagc aatgctggga aatgacaggg aaaatgacag   6900

gaatgaatct caccagattt tttatgtact cagcagagcc ttgagttacg gtgtttattt   6960

tccaatcaag tgaagatatc tcctacttct cctactggaa catctcagct tctgcagtga   7020

agaaaaattc ctgtgatagt tcagttcttt agtttttcta tttgaaaaaa aaaaatcatt   7080

taaatgatcc tttgttcacg gctctcctta atgactgagt gaacagttcc tatctgtata   7140

tttgactaaa ccttttccta agctatctct catggttcct atgttttttt atcataatta   7200

aaagcaaaac catctggatc acctaacagt cagaggtcag tatctcagcg tgtgaattat   7260

agaggaaata cagagagaac ctcttccact tttacttttc gtccaaataa aatgcatggt   7320

gtaccagaag ttgaagatcg ggttgaggat tggggctagc tcgatgacac taaggcccca   7380

acatcgcggg acctgctgtg gcgcggattc ttaggaacgc tgttctagcc ggccccctct   7440

ccaggggtcg ccgtggccgg cattatttcc tagttcttct tgtaaccctg aggtgccagc   7500

gcggggagtg aggaggggtc agggggctaa ggatgcaacc tctgacgttc tgcgccttcc   7560

taggagagtc ttacatgtgt tgagatttca caagcaatgc gagttgtaaa ataccagctc   7620

tacaagaagc taggctctgt gacggcatag ttttcagtag ctttatcaca atattcacaa   7680

tggagaatta tatgacatgg tagcagaaat aggccctttt atgtgttgct tctattttac   7740

ctcaaattgt agatataggg taatcaataa aatccatcca tgcctttcac acactaagt    7799


<210>  4133
<211>  809
<212>  PRT
<213>  Homo sapiens

<400>  4133

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
    450                 455                 460


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
465                 470                 475                 480


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
                485                 490                 495


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
            500                 505                 510


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
        515                 520                 525


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
    530                 535                 540


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
545                 550                 555                 560


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
                565                 570                 575


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
            580                 585                 590


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
        595                 600                 605


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
    610                 615                 620


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
625                 630                 635                 640


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
                645                 650                 655


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
            660                 665                 670


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
        675                 680                 685


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
    690                 695                 700


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
705                 710                 715                 720


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
                725                 730                 735


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
            740                 745                 750


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
        755                 760                 765


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
    770                 775                 780


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
785                 790                 795                 800


Glu Phe Ile Lys Phe Thr Val Ile Arg 
                805


<210>  4134
<211>  4224
<212>  DNA
<213>  Homo sapiens

<400>  4134
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   2040

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2100

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2160

atcaaacccg gagttcttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2220

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2280

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2340

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2400

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2460

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2520

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2580

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2640

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2700

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2760

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2820

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2880

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2940

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   3000

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3060

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca   3120

tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg   3180

atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag   3240

actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc   3300

ctaggcttaa agtatcagtg gttgagaaga gcttttcgga cctgttacta ccccaagctg   3360

tagccttgag ttacggtgtt tattttccaa tcaagtgaag atatctccta cttctcctac   3420

tggaacatct cagcttctgc agtgaagaaa aattcctgtg atagttcagt tctttagttt   3480

ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt tcacggctct ccttaatgac   3540

tgagtgaaca gttcctatct gtatatttga ctaaaccttt tcctaagcta tctctcatgg   3600

ttcctatgtt tttttatcat aattaaaagc aaaaccatct ggatcaccta acagtcagag   3660

gtcagtatct cagcgtgtga attatagagg aaatacagag agaacctctt ccacttttac   3720

ttttcgtcca aataaaatgc atggtgtacc agaagttgaa gatcgggttg aggattgggg   3780

ctagctcgat gacactaagg ccccaacatc gcgggacctg ctgtggcgcg gattcttagg   3840

aacgctgttc tagccggccc cctctccagg ggtcgccgtg gccggcatta tttcctagtt   3900

cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg gctaaggatg   3960

caacctctga cgttctgcgc cttcctagga gagtcttaca tgtgttgaga tttcacaagc   4020

aatgcgagtt gtaaaatacc agctctacaa gaagctaggc tctgtgacgg catagttttc   4080

agtagcttta tcacaatatt cacaatggag aattatatga catggtagca gaaataggcc   4140

cttttatgtg ttgcttctat tttacctcaa attgtagata tagggtaatc aataaaatcc   4200

atccatgcct ttcacacact aagt                                          4224


<210>  4135
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  4135

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
                565                 570                 575


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly 
            580                 585                 590


Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600


<210>  4136
<211>  7073
<212>  DNA
<213>  Homo sapiens

<400>  4136
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1920

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   1980

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttga   2040

aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg aactagttat   2100

ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc agtcccccaa   2160

aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg   2220

ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga ctaacggttc   2280

taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga atgccaaaat   2340

cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg   2400

ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg aagactttta   2460

tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg gcattccgag   2520

gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa agcccgaaat   2580

gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa aaataaattc   2640

atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca ttcaggtgac   2700

aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac agctaagaga   2760

acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg gttttcctgt   2820

gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg atggcatgcc   2880

cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga gaaggatctt   2940

agactctgcc gagtttatca aattcacggt cattaggtaa gtgagagttt cctgcttagt   3000

cacaggagcg aatctggagc tcatgaggct gactcttcta aaatgcagcc acaggtagtc   3060

atcgaatccg gcttcctatg ctgtgcaatc aacaaatcaa aataacttgt gtcatcatta   3120

gaatgtcaga tgtgcttcta cgaactaagc tgactctttt aattctttgg caaagggttg   3180

gcaaactagg actgtttgcc aaattcaggc tgcctcctat ttttagagtc ttcctgaaac   3240

acagctacac ccgtattatc catggctgct ttcctgtcac agtgagtaag tagctgggac   3300

tgagaaggca tggcctccaa agtctaaaat atttactctc tagcactttg tagaaaaacc   3360

ttagctaggc acagtggcta acgcctgtaa tcccagcatt ttgggaggcc aaggcaggca   3420

gatcacctga ggtcaggagt tccagaccag cctggccaac atggtgaaat cccatctcta   3480

caaaaataaa acagttagct gggcatgatg gcgggtgcct gtaatcccag ctactcggga   3540

ggctgaggca ggatagtcgc ttgaacccag gaggtggagg ttgcaatgag ccaagatcat   3600

gccactgcac tccagcctgg acgacagagt gagactccat cacaagaaaa aaagaacttt   3660

gtcaacctct gtcttagggc gccttgtcac aggcttcggg tcagacggat tcaaccttgc   3720

atcagccatt tgttagccag gtcactctgt tctttgtctg taaatgagat tgatcgttgt   3780

tcccactgag agtgtcagct ccttcccgta gagcaggcat gatgattgta ctcacctctg   3840

acaccattgt gagtgccaca ttccttccca cgtccttgtc actgtaagag atgcccacct   3900

gagcaccaac cccaggttat cttccccttt gtcttccagc cccccagaaa cagctacgac   3960

tcaacctacc caatcatttc atcatcagat tgccactgtc tctagttcag gtctcttggg   4020

actggcactc agaaatctca taataaatcc tcttgaggct tctcatacac tcgtcttctt   4080

ccaatcttct ttccctcaaa atctcatatt ttggttccac ttcacccacc gtcattctcc   4140

atatcactcc caggagttag gcaaaaagcc ccttccgttc ttccgtatgt taaacttaga   4200

atcactctgt tccctgctct gcgtttctat tttttgtttt tcctccattt actagtagct   4260

taacactttc taacagtgtt cttattattg atacgtatct atctcttcca taagcttata   4320

aggtcacgga taatacttct cattgtagta cgtaaatgac gtgggctaga tatgagttga   4380

ataaacagtt atacctgtaa attcttacag agtgaaaata aattgttata ctttacaatt   4440

tgtttctctc tttagaccat ttccaggact tgtgattaat aaccgtgagt attttgtgaa   4500

gtgttttgtt tttgtttttt cctggggtct gacgtgtgtg cgtgtgagtg tgtatacatg   4560

cttaacgtat atcacgttac ttcacctatg tcagtaacca ggccaaatac ttgttttagc   4620

cctcagtaaa aacaccaggc acttcctagt tgtaaaatta ttcaagcttc ttaacttcct   4680

atcctcgatg cacttaatca taaaatggta ataatagcac cgattttggg ggagtcgttc   4740

cagtagatgg aaagcatctg gaacaggtgt cagcaagctc ctgccgacgt gtatgcataa   4800

agttttattg aaaccaccat cgtgtccatt tgtttatggc agaactgaga gatggcagca   4860

gcaagtgtgt gcctgcaaaa cctaaaatat ttactaattg gctctgcaag aaaagagttt   4920

gcatccccct aacctagaac agtgtctagc ctctagtatg tgtttagcct acagtatgtg   4980

ctcagcgaat acaatctata tttattactg cttttatgac tgttataatt actgtgcttg   5040

gatttcgtta caaagtaagt cacaatgtgc ctgcttctgt tagtatttca gcacagtgcc   5100

tggcacacat ggggctctca aatattgctg agcgagtgaa caaatgtcct ttcaattcct   5160

taacgttgat gtcattttca atagtatttt gagccaaact taattttgcg agtgtgtttt   5220

gttttcttaa ctttattatt aaaaatgtat aaaagtgagg ccaggcgtgg tggctcacgc   5280

ctgtaatccc agcagtttgg gaggctgagg caggcggatc agttgaggtt gggagttgga   5340

gaccagcccg tccaacatgg tgaaagcctg tctctactaa aaatacaaaa atcagctggg   5400

tgtggtggcg cgtgcctgta atcccagcta ctcaggaggc tgaggcagga gagttgcttg   5460

aatcctagag gtggaggttg cagtgagctg agatcgtgcc attgcactcc agcctgggca   5520

acaagagcaa aactctgtcc caataaataa ataaataaaa tgttctcttt tgttcctgtt   5580

cttgtgcggt agtgtggtat agagttttat ggtaattact gtgaattagt gattctgagg   5640

gacatatcag aactctgagg tttgtttcct tctcatcttg agggaaacag caaatgtatg   5700

ttaaaatgct tttccaaggg aacaacacat ccttacatta tttaaaccaa tctgcttcat   5760

tttcagagct ggttgatcag agtgagtcag aaggccccgt gatacaagaa tcagctgaac   5820

caagccagtt ggaagttcca gccacagaag aaataaaaga gactgatgga agctctcaga   5880

tcaagcaaga accagacccc acgtggtaga cctcttccct cctaggctta aagtatcagt   5940

ggttgagaag agcttttcgg acctgttact accccaagct gtgtaatata cttgtataac   6000

agaaatacct tctatacaaa cctttttttc tacttttaga tagaaatgtc tactttttca   6060

gcagttctgt gaattaaaga gcagagtgac tgtgggtctg gaatggctgg tgtacttggg   6120

aatgtactat caggatttta cagcaatgct gggaaatgac agggaaaatg acaggaatga   6180

atctcaccag attttttatg tactcagcag agccttgagt tacggtgttt attttccaat   6240

caagtgaaga tatctcctac ttctcctact ggaacatctc agcttctgca gtgaagaaaa   6300

attcctgtga tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat catttaaatg   6360

atcctttgtt cacggctctc cttaatgact gagtgaacag ttcctatctg tatatttgac   6420

taaacctttt cctaagctat ctctcatggt tcctatgttt ttttatcata attaaaagca   6480

aaaccatctg gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa ttatagagga   6540

aatacagaga gaacctcttc cacttttact tttcgtccaa ataaaatgca tggtgtacca   6600

gaagttgaag atcgggttga ggattggggc tagctcgatg acactaaggc cccaacatcg   6660

cgggacctgc tgtggcgcgg attcttagga acgctgttct agccggcccc ctctccaggg   6720

gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg   6780

agtgaggagg ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc ttcctaggag   6840

agtcttacat gtgttgagat ttcacaagca atgcgagttg taaaatacca gctctacaag   6900

aagctaggct ctgtgacggc atagttttca gtagctttat cacaatattc acaatggaga   6960

attatatgac atggtagcag aaataggccc ttttatgtgt tgcttctatt ttacctcaaa   7020

ttgtagatat agggtaatca ataaaatcca tccatgcctt tcacacacta agt          7073


<210>  4137
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  4137

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
            500                 505                 510


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
        515                 520                 525


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
    530                 535                 540


Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu 
545                 550                 555                 560


Lys Asn Leu Asn 



<210>  4138
<211>  4302
<212>  DNA
<213>  Homo sapiens

<400>  4138
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   2040

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2100

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2160

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2220

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2280

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2340

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2400

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2460

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2520

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2580

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2640

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2700

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2760

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2820

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2880

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   2940

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   3000

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3060

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3120

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3180

ttcacggtca ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt   3240

gagtcagaag gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc   3300

acagaagaaa taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg   3360

tggtagacct cttccctcct aggcttaaag tatcagtggt tgagaagagc ttttcggacc   3420

tgttactacc ccaagctgta gccttgagtt acggtgttta ttttccaatc aagtgaagat   3480

atctcctact tctcctactg gaacatctca gcttctgcag tgaagaaaaa ttcctgtgat   3540

agttcagttc tttagttttt ctatttgaaa aaaaaaaatc atttaaatga tcctttgttc   3600

acggctctcc ttaatgactg agtgaacagt tcctatctgt atatttgact aaaccttttc   3660

ctaagctatc tctcatggtt cctatgtttt tttatcataa ttaaaagcaa aaccatctgg   3720

atcacctaac agtcagaggt cagtatctca gcgtgtgaat tatagaggaa atacagagag   3780

aacctcttcc acttttactt ttcgtccaaa taaaatgcat ggtgtaccag aagttgaaga   3840

tcgggttgag gattggggct agctcgatga cactaaggcc ccaacatcgc gggacctgct   3900

gtggcgcgga ttcttaggaa cgctgttcta gccggccccc tctccagggg tcgccgtggc   3960

cggcattatt tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga gtgaggaggg   4020

gtcagggggc taaggatgca acctctgacg ttctgcgcct tcctaggaga gtcttacatg   4080

tgttgagatt tcacaagcaa tgcgagttgt aaaataccag ctctacaaga agctaggctc   4140

tgtgacggca tagttttcag tagctttatc acaatattca caatggagaa ttatatgaca   4200

tggtagcaga aataggccct tttatgtgtt gcttctattt tacctcaaat tgtagatata   4260

gggtaatcaa taaaatccat ccatgccttt cacacactaa gt                      4302


<210>  4139
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  4139

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
    450                 455                 460


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
465                 470                 475


<210>  4140
<211>  5207
<212>  DNA
<213>  Homo sapiens

<400>  4140
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2100

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2160

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2220

tgaatcaaac ccggagttct tgaaaggatc gtccgcggga gtaataaaat caagttcgtt   2280

gttaaaaaac ctgaactagt tatttcctac ttgcctcctg ggatggctag taaaataaac   2340

actaaagctt tgcagtcccc caaaagacca cgaagtcctg ggagtaattc aaaggttcct   2400

gaaattgagg tcaccgtgga aggccctaat aacaacaatc ctcaaacctc agctgttcga   2460

accccgaccc agactaacgg ttctaacgtt cccttcaagc cacgagggag agagttttcc   2520

tttgaggcct ggaatgccaa aatcacggac ctaaaacaga aagttgaaaa tctcttcaat   2580

gagaaatgtg gggaagctct tggccttaaa caagctgtga aggtgccgtt cgcgttattt   2640

gagtctttcc cggaagactt ttatgtggaa ggcttacctg agggtgtgcc attccgaaga   2700

ccatcgactt ttggcattcc gaggctggag aagatactca gaaacaaagc caaaattaag   2760

ttcatcatta aaaagcccga aatgtttgag acggcgatta aggagagcac ctcctctaag   2820

agccctccca gaaaaataaa ttcatcaccc aatgttaata ctactgcatc aggtgttgaa   2880

gaccttaaca tcattcaggt gacaattcca gatgatgata atgaaagact ctcgaaagtt   2940

gaaaaagcta gacagctaag agaacaagtg aatgacctct ttagtcggaa atttggtgaa   3000

gctattggta tgggttttcc tgtgaaagtt ccctacagga aaatcacaat taaccctggc   3060

tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca aagcccccag ctacctggaa   3120

atcagctcca tgagaaggat cttagactct gccgagttta tcaaattcac ggtcattaga   3180

ccatttccag gacttgtgat taataaccag ctggttgatc agagtgagtc agaaggcccc   3240

gtgatacaag aatcagctga accaagccag ttggaagttc cagccacaga agaaataaaa   3300

gagactgatg gaagctctca gatcaagcaa gaaccagacc ccacgtggta gacctcttcc   3360

ctcctagggt aaatcagctt ctgtgtcagg gatgctgtgt ggtgtccatc tgaaccccct   3420

gcatacgcgt agctaatgtg atctccccac tttcacataa gatggtggcc ctgccttcag   3480

ggaatgtggg agccaggtgg gagccttccc ggatatttaa gctagaagat tctacaggga   3540

gattctcctt ggatcaatat atgtctctca gtcaaagatg taaaagcact tttgccttaa   3600

aaagaatgtt ctgtttctaa atagagtcaa cgttgtcctc ctcattggaa ttcactatga   3660

gtcagaatca ttagactgac tttttttttt ccatagtaat agtattttgc agagtctcac   3720

agagctgcag atcttttgtt catcttgcag agttaacaag tctgatcctg ttagtccaga   3780

tttcttaaat ttggccaagt tataatagga gcagtagctt gagacccgaa gtcaggaaac   3840

tttgacaatg gatttttttt tttaatccag agacttgtac tggaatttgc cttaccctgt   3900

cagctcatgg acttaaggtt tcatcccgct ttatgagtgc ttctgaatcc aagtcattgt   3960

tacctgaatt tgcaaattaa gttgtgatat tcgtgactgt taaattcctg taattagatt   4020

aacctctttg cttgcttgtt tgttttctct cctattttag cttaaagtat cagtggttga   4080

gaagagcttt tcggacctgt tactacccca agctgtgtaa tatacttgta taacagaaat   4140

accttctata caaacctttt tttctacttt tagatagaaa tgtctacttt ttcagcagtt   4200

ctgtgaatta aagagcagag tgactgtggg tctggaatgg ctggtgtact tgggaatgta   4260

ctatcaggat tttacagcaa tgctgggaaa tgacagggaa aatgacagga atgaatctca   4320

ccagattttt tatgtactca gcagagcctt gagttacggt gtttattttc caatcaagtg   4380

aagatatctc ctacttctcc tactggaaca tctcagcttc tgcagtgaag aaaaattcct   4440

gtgatagttc agttctttag tttttctatt tgaaaaaaaa aaatcattta aatgatcctt   4500

tgttcacggc tctccttaat gactgagtga acagttccta tctgtatatt tgactaaacc   4560

ttttcctaag ctatctctca tggttcctat gtttttttat cataattaaa agcaaaacca   4620

tctggatcac ctaacagtca gaggtcagta tctcagcgtg tgaattatag aggaaataca   4680

gagagaacct cttccacttt tacttttcgt ccaaataaaa tgcatggtgt accagaagtt   4740

gaagatcggg ttgaggattg gggctagctc gatgacacta aggccccaac atcgcgggac   4800

ctgctgtggc gcggattctt aggaacgctg ttctagccgg ccccctctcc aggggtcgcc   4860

gtggccggca ttatttccta gttcttcttg taaccctgag gtgccagcgc ggggagtgag   4920

gaggggtcag ggggctaagg atgcaacctc tgacgttctg cgccttccta ggagagtctt   4980

acatgtgttg agatttcaca agcaatgcga gttgtaaaat accagctcta caagaagcta   5040

ggctctgtga cggcatagtt ttcagtagct ttatcacaat attcacaatg gagaattata   5100

tgacatggta gcagaaatag gcccttttat gtgttgcttc tattttacct caaattgtag   5160

atatagggta atcaataaaa tccatccatg cctttcacac actaagt                 5207


<210>  4141
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  4141

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys 
        595                 600                 605


Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu 
    610                 615                 620


Asn 
625


<210>  4142
<211>  7830
<212>  DNA
<213>  Homo sapiens

<400>  4142
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gtcaaagaag attggaatgt   1980

cagaattacc aagctacgga agcaagtgga agagattttt aatttgaaat ttgctcaagc   2040

tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt   2100

cttgaaagga tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa acctgaacta   2160

gttatttcct acttgcctcc tgggatggct agtaaaataa acactaaagc tttgcagtcc   2220

cccaaaagac cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg   2280

gaaggcccta ataacaacaa tcctcaaacc tcagctgttc gaaccccgac ccagactaac   2340

ggttctaacg ttcccttcaa gccacgaggg agagagtttt cctttgaggc ctggaatgcc   2400

aaaatcacgg acctaaaaca gaaagttgaa aatctcttca atgagaaatg tggggaagct   2460

cttggcctta aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac   2520

ttttatgtgg aaggcttacc tgagggtgtg ccattccgaa gaccatcgac ttttggcatt   2580

ccgaggctgg agaagatact cagaaacaaa gccaaaatta agttcatcat taaaaagccc   2640

gaaatgtttg agacggcgat taaggagagc acctcctcta agagccctcc cagaaaaata   2700

aattcatcac ccaatgttaa tactactgca tcaggtgttg aagaccttaa catcattcag   2760

gtgacaattc cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta   2820

agagaacaag tgaatgacct ctttagtcgg aaatttggtg aagctattgg tatgggtttt   2880

cctgtgaaag ttccctacag gaaaatcaca attaaccctg gctgtgtggt ggttgatggc   2940

atgcccccgg gggtgtcctt caaagccccc agctacctgg aaatcagctc catgagaagg   3000

atcttagact ctgccgagtt tatcaaattc acggtcatta ggtaagtgag agtttcctgc   3060

ttagtcacag gagcgaatct ggagctcatg aggctgactc ttctaaaatg cagccacagg   3120

tagtcatcga atccggcttc ctatgctgtg caatcaacaa atcaaaataa cttgtgtcat   3180

cattagaatg tcagatgtgc ttctacgaac taagctgact cttttaattc tttggcaaag   3240

ggttggcaaa ctaggactgt ttgccaaatt caggctgcct cctattttta gagtcttcct   3300

gaaacacagc tacacccgta ttatccatgg ctgctttcct gtcacagtga gtaagtagct   3360

gggactgaga aggcatggcc tccaaagtct aaaatattta ctctctagca ctttgtagaa   3420

aaaccttagc taggcacagt ggctaacgcc tgtaatccca gcattttggg aggccaaggc   3480

aggcagatca cctgaggtca ggagttccag accagcctgg ccaacatggt gaaatcccat   3540

ctctacaaaa ataaaacagt tagctgggca tgatggcggg tgcctgtaat cccagctact   3600

cgggaggctg aggcaggata gtcgcttgaa cccaggaggt ggaggttgca atgagccaag   3660

atcatgccac tgcactccag cctggacgac agagtgagac tccatcacaa gaaaaaaaga   3720

actttgtcaa cctctgtctt agggcgcctt gtcacaggct tcgggtcaga cggattcaac   3780

cttgcatcag ccatttgtta gccaggtcac tctgttcttt gtctgtaaat gagattgatc   3840

gttgttccca ctgagagtgt cagctccttc ccgtagagca ggcatgatga ttgtactcac   3900

ctctgacacc attgtgagtg ccacattcct tcccacgtcc ttgtcactgt aagagatgcc   3960

cacctgagca ccaaccccag gttatcttcc cctttgtctt ccagcccccc agaaacagct   4020

acgactcaac ctacccaatc atttcatcat cagattgcca ctgtctctag ttcaggtctc   4080

ttgggactgg cactcagaaa tctcataata aatcctcttg aggcttctca tacactcgtc   4140

ttcttccaat cttctttccc tcaaaatctc atattttggt tccacttcac ccaccgtcat   4200

tctccatatc actcccagga gttaggcaaa aagccccttc cgttcttccg tatgttaaac   4260

ttagaatcac tctgttccct gctctgcgtt tctatttttt gtttttcctc catttactag   4320

tagcttaaca ctttctaaca gtgttcttat tattgatacg tatctatctc ttccataagc   4380

ttataaggtc acggataata cttctcattg tagtacgtaa atgacgtggg ctagatatga   4440

gttgaataaa cagttatacc tgtaaattct tacagagtga aaataaattg ttatacttta   4500

caatttgttt ctctctttag accatttcca ggacttgtga ttaataaccg tgagtatttt   4560

gtgaagtgtt ttgtttttgt tttttcctgg ggtctgacgt gtgtgcgtgt gagtgtgtat   4620

acatgcttaa cgtatatcac gttacttcac ctatgtcagt aaccaggcca aatacttgtt   4680

ttagccctca gtaaaaacac caggcacttc ctagttgtaa aattattcaa gcttcttaac   4740

ttcctatcct cgatgcactt aatcataaaa tggtaataat agcaccgatt ttgggggagt   4800

cgttccagta gatggaaagc atctggaaca ggtgtcagca agctcctgcc gacgtgtatg   4860

cataaagttt tattgaaacc accatcgtgt ccatttgttt atggcagaac tgagagatgg   4920

cagcagcaag tgtgtgcctg caaaacctaa aatatttact aattggctct gcaagaaaag   4980

agtttgcatc cccctaacct agaacagtgt ctagcctcta gtatgtgttt agcctacagt   5040

atgtgctcag cgaatacaat ctatatttat tactgctttt atgactgtta taattactgt   5100

gcttggattt cgttacaaag taagtcacaa tgtgcctgct tctgttagta tttcagcaca   5160

gtgcctggca cacatggggc tctcaaatat tgctgagcga gtgaacaaat gtcctttcaa   5220

ttccttaacg ttgatgtcat tttcaatagt attttgagcc aaacttaatt ttgcgagtgt   5280

gttttgtttt cttaacttta ttattaaaaa tgtataaaag tgaggccagg cgtggtggct   5340

cacgcctgta atcccagcag tttgggaggc tgaggcaggc ggatcagttg aggttgggag   5400

ttggagacca gcccgtccaa catggtgaaa gcctgtctct actaaaaata caaaaatcag   5460

ctgggtgtgg tggcgcgtgc ctgtaatccc agctactcag gaggctgagg caggagagtt   5520

gcttgaatcc tagaggtgga ggttgcagtg agctgagatc gtgccattgc actccagcct   5580

gggcaacaag agcaaaactc tgtcccaata aataaataaa taaaatgttc tcttttgttc   5640

ctgttcttgt gcggtagtgt ggtatagagt tttatggtaa ttactgtgaa ttagtgattc   5700

tgagggacat atcagaactc tgaggtttgt ttccttctca tcttgaggga aacagcaaat   5760

gtatgttaaa atgcttttcc aagggaacaa cacatcctta cattatttaa accaatctgc   5820

ttcattttca gagctggttg atcagagtga gtcagaaggc cccgtgatac aagaatcagc   5880

tgaaccaagc cagttggaag ttccagccac agaagaaata aaagagactg atggaagctc   5940

tcagatcaag caagaaccag accccacgtg gtagacctct tccctcctag ggtaaatcag   6000

cttctgtgtc agggatgctg tgtggtgtcc atctgaaccc cctgcatacg cgtagctaat   6060

gtgatctccc cactttcaca taagatggtg gccctgcctt cagggaatgt gggagccagg   6120

tgggagcctt cccggatatt taagctagaa gattctacag ggagattctc cttggatcaa   6180

tatatgtctc tcagtcaaag atgtaaaagc acttttgcct taaaaagaat gttctgtttc   6240

taaatagagt caacgttgtc ctcctcattg gaattcacta tgagtcagaa tcattagact   6300

gacttttttt tttccatagt aatagtattt tgcagagtct cacagagctg cagatctttt   6360

gttcatcttg cagagttaac aagtctgatc ctgttagtcc agatttctta aatttggcca   6420

agttataata ggagcagtag cttgagaccc gaagtcagga aactttgaca atggattttt   6480

ttttttaatc cagagacttg tactggaatt tgccttaccc tgtcagctca tggacttaag   6540

gtttcatccc gctttatgag tgcttctgaa tccaagtcat tgttacctga atttgcaaat   6600

taagttgtga tattcgtgac tgttaaattc ctgtaattag attaacctct ttgcttgctt   6660

gtttgttttc tctcctattt tagcttaaag tatcagtggt tgagaagagc ttttcggacc   6720

tgttactacc ccaagctgtg taatatactt gtataacaga aataccttct atacaaacct   6780

ttttttctac ttttagatag aaatgtctac tttttcagca gttctgtgaa ttaaagagca   6840

gagtgactgt gggtctggaa tggctggtgt acttgggaat gtactatcag gattttacag   6900

caatgctggg aaatgacagg gaaaatgaca ggaatgaatc tcaccagatt ttttatgtac   6960

tcagcagagc cttgagttac ggtgtttatt ttccaatcaa gtgaagatat ctcctacttc   7020

tcctactgga acatctcagc ttctgcagtg aagaaaaatt cctgtgatag ttcagttctt   7080

tagtttttct atttgaaaaa aaaaaatcat ttaaatgatc ctttgttcac ggctctcctt   7140

aatgactgag tgaacagttc ctatctgtat atttgactaa accttttcct aagctatctc   7200

tcatggttcc tatgtttttt tatcataatt aaaagcaaaa ccatctggat cacctaacag   7260

tcagaggtca gtatctcagc gtgtgaatta tagaggaaat acagagagaa cctcttccac   7320

ttttactttt cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc gggttgagga   7380

ttggggctag ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt ggcgcggatt   7440

cttaggaacg ctgttctagc cggccccctc tccaggggtc gccgtggccg gcattatttc   7500

ctagttcttc ttgtaaccct gaggtgccag cgcggggagt gaggaggggt cagggggcta   7560

aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg ttgagatttc   7620

acaagcaatg cgagttgtaa aataccagct ctacaagaag ctaggctctg tgacggcata   7680

gttttcagta gctttatcac aatattcaca atggagaatt atatgacatg gtagcagaaa   7740

taggcccttt tatgtgttgc ttctatttta cctcaaattg tagatatagg gtaatcaata   7800

aaatccatcc atgcctttca cacactaagt                                    7830


<210>  4143
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  4143

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys 
                565                 570                 575


Asn Leu Asn 



<210>  4144
<211>  7736
<212>  DNA
<213>  Homo sapiens

<400>  4144
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agctcaagct cttggactca ccgaggcagt aaaagtacca tatcctgtgt   1920

ttgaatcaaa cccggagttc ttgtatgtgg aaggcttgcc agaggggatt cccttccgaa   1980

gccctacctg gtttggaatt ccacgacttg aaaggatcgt ccgcgggagt aataaaatca   2040

agttcgttgt taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta   2100

aaataaacac taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa   2160

aggttcctga aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag   2220

ctgttcgaac cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag   2280

agttttcctt tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc   2340

tcttcaatga gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg   2400

cgttatttga gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat   2460

tccgaagacc atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca   2520

aaattaagtt catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct   2580

cctctaagag ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag   2640

gtgttgaaga ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct   2700

cgaaagttga aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat   2760

ttggtgaagc tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta   2820

accctggctg tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct   2880

acctggaaat cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg   2940

tcattaggta agtgagagtt tcctgcttag tcacaggagc gaatctggag ctcatgaggc   3000

tgactcttct aaaatgcagc cacaggtagt catcgaatcc ggcttcctat gctgtgcaat   3060

caacaaatca aaataacttg tgtcatcatt agaatgtcag atgtgcttct acgaactaag   3120

ctgactcttt taattctttg gcaaagggtt ggcaaactag gactgtttgc caaattcagg   3180

ctgcctccta tttttagagt cttcctgaaa cacagctaca cccgtattat ccatggctgc   3240

tttcctgtca cagtgagtaa gtagctggga ctgagaaggc atggcctcca aagtctaaaa   3300

tatttactct ctagcacttt gtagaaaaac cttagctagg cacagtggct aacgcctgta   3360

atcccagcat tttgggaggc caaggcaggc agatcacctg aggtcaggag ttccagacca   3420

gcctggccaa catggtgaaa tcccatctct acaaaaataa aacagttagc tgggcatgat   3480

ggcgggtgcc tgtaatccca gctactcggg aggctgaggc aggatagtcg cttgaaccca   3540

ggaggtggag gttgcaatga gccaagatca tgccactgca ctccagcctg gacgacagag   3600

tgagactcca tcacaagaaa aaaagaactt tgtcaacctc tgtcttaggg cgccttgtca   3660

caggcttcgg gtcagacgga ttcaaccttg catcagccat ttgttagcca ggtcactctg   3720

ttctttgtct gtaaatgaga ttgatcgttg ttcccactga gagtgtcagc tccttcccgt   3780

agagcaggca tgatgattgt actcacctct gacaccattg tgagtgccac attccttccc   3840

acgtccttgt cactgtaaga gatgcccacc tgagcaccaa ccccaggtta tcttcccctt   3900

tgtcttccag ccccccagaa acagctacga ctcaacctac ccaatcattt catcatcaga   3960

ttgccactgt ctctagttca ggtctcttgg gactggcact cagaaatctc ataataaatc   4020

ctcttgaggc ttctcataca ctcgtcttct tccaatcttc tttccctcaa aatctcatat   4080

tttggttcca cttcacccac cgtcattctc catatcactc ccaggagtta ggcaaaaagc   4140

cccttccgtt cttccgtatg ttaaacttag aatcactctg ttccctgctc tgcgtttcta   4200

ttttttgttt ttcctccatt tactagtagc ttaacacttt ctaacagtgt tcttattatt   4260

gatacgtatc tatctcttcc ataagcttat aaggtcacgg ataatacttc tcattgtagt   4320

acgtaaatga cgtgggctag atatgagttg aataaacagt tatacctgta aattcttaca   4380

gagtgaaaat aaattgttat actttacaat ttgtttctct ctttagacca tttccaggac   4440

ttgtgattaa taaccgtgag tattttgtga agtgttttgt ttttgttttt tcctggggtc   4500

tgacgtgtgt gcgtgtgagt gtgtatacat gcttaacgta tatcacgtta cttcacctat   4560

gtcagtaacc aggccaaata cttgttttag ccctcagtaa aaacaccagg cacttcctag   4620

ttgtaaaatt attcaagctt cttaacttcc tatcctcgat gcacttaatc ataaaatggt   4680

aataatagca ccgattttgg gggagtcgtt ccagtagatg gaaagcatct ggaacaggtg   4740

tcagcaagct cctgccgacg tgtatgcata aagttttatt gaaaccacca tcgtgtccat   4800

ttgtttatgg cagaactgag agatggcagc agcaagtgtg tgcctgcaaa acctaaaata   4860

tttactaatt ggctctgcaa gaaaagagtt tgcatccccc taacctagaa cagtgtctag   4920

cctctagtat gtgtttagcc tacagtatgt gctcagcgaa tacaatctat atttattact   4980

gcttttatga ctgttataat tactgtgctt ggatttcgtt acaaagtaag tcacaatgtg   5040

cctgcttctg ttagtatttc agcacagtgc ctggcacaca tggggctctc aaatattgct   5100

gagcgagtga acaaatgtcc tttcaattcc ttaacgttga tgtcattttc aatagtattt   5160

tgagccaaac ttaattttgc gagtgtgttt tgttttctta actttattat taaaaatgta   5220

taaaagtgag gccaggcgtg gtggctcacg cctgtaatcc cagcagtttg ggaggctgag   5280

gcaggcggat cagttgaggt tgggagttgg agaccagccc gtccaacatg gtgaaagcct   5340

gtctctacta aaaatacaaa aatcagctgg gtgtggtggc gcgtgcctgt aatcccagct   5400

actcaggagg ctgaggcagg agagttgctt gaatcctaga ggtggaggtt gcagtgagct   5460

gagatcgtgc cattgcactc cagcctgggc aacaagagca aaactctgtc ccaataaata   5520

aataaataaa atgttctctt ttgttcctgt tcttgtgcgg tagtgtggta tagagtttta   5580

tggtaattac tgtgaattag tgattctgag ggacatatca gaactctgag gtttgtttcc   5640

ttctcatctt gagggaaaca gcaaatgtat gttaaaatgc ttttccaagg gaacaacaca   5700

tccttacatt atttaaacca atctgcttca ttttcagagc tggttgatca gagtgagtca   5760

gaaggccccg tgatacaaga atcagctgaa ccaagccagt tggaagttcc agccacagaa   5820

gaaataaaag agactgatgg aagctctcag atcaagcaag aaccagaccc cacgtggtag   5880

acctcttccc tcctagggta aatcagcttc tgtgtcaggg atgctgtgtg gtgtccatct   5940

gaaccccctg catacgcgta gctaatgtga tctccccact ttcacataag atggtggccc   6000

tgccttcagg gaatgtggga gccaggtggg agccttcccg gatatttaag ctagaagatt   6060

ctacagggag attctccttg gatcaatata tgtctctcag tcaaagatgt aaaagcactt   6120

ttgccttaaa aagaatgttc tgtttctaaa tagagtcaac gttgtcctcc tcattggaat   6180

tcactatgag tcagaatcat tagactgact tttttttttc catagtaata gtattttgca   6240

gagtctcaca gagctgcaga tcttttgttc atcttgcaga gttaacaagt ctgatcctgt   6300

tagtccagat ttcttaaatt tggccaagtt ataataggag cagtagcttg agacccgaag   6360

tcaggaaact ttgacaatgg attttttttt ttaatccaga gacttgtact ggaatttgcc   6420

ttaccctgtc agctcatgga cttaaggttt catcccgctt tatgagtgct tctgaatcca   6480

agtcattgtt acctgaattt gcaaattaag ttgtgatatt cgtgactgtt aaattcctgt   6540

aattagatta acctctttgc ttgcttgttt gttttctctc ctattttagc ttaaagtatc   6600

agtggttgag aagagctttt cggacctgtt actaccccaa gctgtgtaat atacttgtat   6660

aacagaaata ccttctatac aaaccttttt ttctactttt agatagaaat gtctactttt   6720

tcagcagttc tgtgaattaa agagcagagt gactgtgggt ctggaatggc tggtgtactt   6780

gggaatgtac tatcaggatt ttacagcaat gctgggaaat gacagggaaa atgacaggaa   6840

tgaatctcac cagatttttt atgtactcag cagagccttg agttacggtg tttattttcc   6900

aatcaagtga agatatctcc tacttctcct actggaacat ctcagcttct gcagtgaaga   6960

aaaattcctg tgatagttca gttctttagt ttttctattt gaaaaaaaaa aatcatttaa   7020

atgatccttt gttcacggct ctccttaatg actgagtgaa cagttcctat ctgtatattt   7080

gactaaacct tttcctaagc tatctctcat ggttcctatg tttttttatc ataattaaaa   7140

gcaaaaccat ctggatcacc taacagtcag aggtcagtat ctcagcgtgt gaattataga   7200

ggaaatacag agagaacctc ttccactttt acttttcgtc caaataaaat gcatggtgta   7260

ccagaagttg aagatcgggt tgaggattgg ggctagctcg atgacactaa ggccccaaca   7320

tcgcgggacc tgctgtggcg cggattctta ggaacgctgt tctagccggc cccctctcca   7380

ggggtcgccg tggccggcat tatttcctag ttcttcttgt aaccctgagg tgccagcgcg   7440

gggagtgagg aggggtcagg gggctaagga tgcaacctct gacgttctgc gccttcctag   7500

gagagtctta catgtgttga gatttcacaa gcaatgcgag ttgtaaaata ccagctctac   7560

aagaagctag gctctgtgac ggcatagttt tcagtagctt tatcacaata ttcacaatgg   7620

agaattatat gacatggtag cagaaatagg cccttttatg tgttgcttct attttacctc   7680

aaattgtaga tatagggtaa tcaataaaat ccatccatgc ctttcacaca ctaagt       7736


<210>  4145
<211>  788
<212>  PRT
<213>  Homo sapiens

<400>  4145

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala 
            420                 425                 430


Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser 
        435                 440                 445


Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
    450                 455                 460


Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg 
465                 470                 475                 480


Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile 
                485                 490                 495


Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu 
            500                 505                 510


Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro 
        515                 520                 525


Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr 
    530                 535                 540


Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe 
545                 550                 555                 560


Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile 
                565                 570                 575


Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly 
            580                 585                 590


Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe 
        595                 600                 605


Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val 
    610                 615                 620


Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile 
625                 630                 635                 640


Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met 
                645                 650                 655


Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg 
            660                 665                 670


Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu 
        675                 680                 685


Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg 
    690                 695                 700


Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp 
705                 710                 715                 720


Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val 
                725                 730                 735


Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val 
            740                 745                 750


Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu 
        755                 760                 765


Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe 
    770                 775                 780


Thr Val Ile Arg 
785


<210>  4146
<211>  7905
<212>  DNA
<213>  Homo sapiens

<400>  4146
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1860

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1920

tgaaatttgc ttagatttgt tgacagcggt ttcctggagt gctgtcttga gaacgattct   1980

gaggaggctc agcaagaaag agtgtttcag ttgattgggt gtgtctgtca tggagaagga   2040

actcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac   2100

ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg   2160

tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2220

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2280

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2340

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2400

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2460

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2520

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2580

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2640

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2700

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2760

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2820

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2880

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2940

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   3000

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3060

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattaggtaa   3120

gtgagagttt cctgcttagt cacaggagcg aatctggagc tcatgaggct gactcttcta   3180

aaatgcagcc acaggtagtc atcgaatccg gcttcctatg ctgtgcaatc aacaaatcaa   3240

aataacttgt gtcatcatta gaatgtcaga tgtgcttcta cgaactaagc tgactctttt   3300

aattctttgg caaagggttg gcaaactagg actgtttgcc aaattcaggc tgcctcctat   3360

ttttagagtc ttcctgaaac acagctacac ccgtattatc catggctgct ttcctgtcac   3420

agtgagtaag tagctgggac tgagaaggca tggcctccaa agtctaaaat atttactctc   3480

tagcactttg tagaaaaacc ttagctaggc acagtggcta acgcctgtaa tcccagcatt   3540

ttgggaggcc aaggcaggca gatcacctga ggtcaggagt tccagaccag cctggccaac   3600

atggtgaaat cccatctcta caaaaataaa acagttagct gggcatgatg gcgggtgcct   3660

gtaatcccag ctactcggga ggctgaggca ggatagtcgc ttgaacccag gaggtggagg   3720

ttgcaatgag ccaagatcat gccactgcac tccagcctgg acgacagagt gagactccat   3780

cacaagaaaa aaagaacttt gtcaacctct gtcttagggc gccttgtcac aggcttcggg   3840

tcagacggat tcaaccttgc atcagccatt tgttagccag gtcactctgt tctttgtctg   3900

taaatgagat tgatcgttgt tcccactgag agtgtcagct ccttcccgta gagcaggcat   3960

gatgattgta ctcacctctg acaccattgt gagtgccaca ttccttccca cgtccttgtc   4020

actgtaagag atgcccacct gagcaccaac cccaggttat cttccccttt gtcttccagc   4080

cccccagaaa cagctacgac tcaacctacc caatcatttc atcatcagat tgccactgtc   4140

tctagttcag gtctcttggg actggcactc agaaatctca taataaatcc tcttgaggct   4200

tctcatacac tcgtcttctt ccaatcttct ttccctcaaa atctcatatt ttggttccac   4260

ttcacccacc gtcattctcc atatcactcc caggagttag gcaaaaagcc ccttccgttc   4320

ttccgtatgt taaacttaga atcactctgt tccctgctct gcgtttctat tttttgtttt   4380

tcctccattt actagtagct taacactttc taacagtgtt cttattattg atacgtatct   4440

atctcttcca taagcttata aggtcacgga taatacttct cattgtagta cgtaaatgac   4500

gtgggctaga tatgagttga ataaacagtt atacctgtaa attcttacag agtgaaaata   4560

aattgttata ctttacaatt tgtttctctc tttagaccat ttccaggact tgtgattaat   4620

aaccgtgagt attttgtgaa gtgttttgtt tttgtttttt cctggggtct gacgtgtgtg   4680

cgtgtgagtg tgtatacatg cttaacgtat atcacgttac ttcacctatg tcagtaacca   4740

ggccaaatac ttgttttagc cctcagtaaa aacaccaggc acttcctagt tgtaaaatta   4800

ttcaagcttc ttaacttcct atcctcgatg cacttaatca taaaatggta ataatagcac   4860

cgattttggg ggagtcgttc cagtagatgg aaagcatctg gaacaggtgt cagcaagctc   4920

ctgccgacgt gtatgcataa agttttattg aaaccaccat cgtgtccatt tgtttatggc   4980

agaactgaga gatggcagca gcaagtgtgt gcctgcaaaa cctaaaatat ttactaattg   5040

gctctgcaag aaaagagttt gcatccccct aacctagaac agtgtctagc ctctagtatg   5100

tgtttagcct acagtatgtg ctcagcgaat acaatctata tttattactg cttttatgac   5160

tgttataatt actgtgcttg gatttcgtta caaagtaagt cacaatgtgc ctgcttctgt   5220

tagtatttca gcacagtgcc tggcacacat ggggctctca aatattgctg agcgagtgaa   5280

caaatgtcct ttcaattcct taacgttgat gtcattttca atagtatttt gagccaaact   5340

taattttgcg agtgtgtttt gttttcttaa ctttattatt aaaaatgtat aaaagtgagg   5400

ccaggcgtgg tggctcacgc ctgtaatccc agcagtttgg gaggctgagg caggcggatc   5460

agttgaggtt gggagttgga gaccagcccg tccaacatgg tgaaagcctg tctctactaa   5520

aaatacaaaa atcagctggg tgtggtggcg cgtgcctgta atcccagcta ctcaggaggc   5580

tgaggcagga gagttgcttg aatcctagag gtggaggttg cagtgagctg agatcgtgcc   5640

attgcactcc agcctgggca acaagagcaa aactctgtcc caataaataa ataaataaaa   5700

tgttctcttt tgttcctgtt cttgtgcggt agtgtggtat agagttttat ggtaattact   5760

gtgaattagt gattctgagg gacatatcag aactctgagg tttgtttcct tctcatcttg   5820

agggaaacag caaatgtatg ttaaaatgct tttccaaggg aacaacacat ccttacatta   5880

tttaaaccaa tctgcttcat tttcagagct ggttgatcag agtgagtcag aaggccccgt   5940

gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag aaataaaaga   6000

gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga cctcttccct   6060

cctagggtaa atcagcttct gtgtcaggga tgctgtgtgg tgtccatctg aaccccctgc   6120

atacgcgtag ctaatgtgat ctccccactt tcacataaga tggtggccct gccttcaggg   6180

aatgtgggag ccaggtggga gccttcccgg atatttaagc tagaagattc tacagggaga   6240

ttctccttgg atcaatatat gtctctcagt caaagatgta aaagcacttt tgccttaaaa   6300

agaatgttct gtttctaaat agagtcaacg ttgtcctcct cattggaatt cactatgagt   6360

cagaatcatt agactgactt ttttttttcc atagtaatag tattttgcag agtctcacag   6420

agctgcagat cttttgttca tcttgcagag ttaacaagtc tgatcctgtt agtccagatt   6480

tcttaaattt ggccaagtta taataggagc agtagcttga gacccgaagt caggaaactt   6540

tgacaatgga tttttttttt taatccagag acttgtactg gaatttgcct taccctgtca   6600

gctcatggac ttaaggtttc atcccgcttt atgagtgctt ctgaatccaa gtcattgtta   6660

cctgaatttg caaattaagt tgtgatattc gtgactgtta aattcctgta attagattaa   6720

cctctttgct tgcttgtttg ttttctctcc tattttagct taaagtatca gtggttgaga   6780

agagcttttc ggacctgtta ctaccccaag ctgtgtaata tacttgtata acagaaatac   6840

cttctataca aacctttttt tctactttta gatagaaatg tctacttttt cagcagttct   6900

gtgaattaaa gagcagagtg actgtgggtc tggaatggct ggtgtacttg ggaatgtact   6960

atcaggattt tacagcaatg ctgggaaatg acagggaaaa tgacaggaat gaatctcacc   7020

agatttttta tgtactcagc agagccttga gttacggtgt ttattttcca atcaagtgaa   7080

gatatctcct acttctccta ctggaacatc tcagcttctg cagtgaagaa aaattcctgt   7140

gatagttcag ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa tgatcctttg   7200

ttcacggctc tccttaatga ctgagtgaac agttcctatc tgtatatttg actaaacctt   7260

ttcctaagct atctctcatg gttcctatgt ttttttatca taattaaaag caaaaccatc   7320

tggatcacct aacagtcaga ggtcagtatc tcagcgtgtg aattatagag gaaatacaga   7380

gagaacctct tccactttta cttttcgtcc aaataaaatg catggtgtac cagaagttga   7440

agatcgggtt gaggattggg gctagctcga tgacactaag gccccaacat cgcgggacct   7500

gctgtggcgc ggattcttag gaacgctgtt ctagccggcc ccctctccag gggtcgccgt   7560

ggccggcatt atttcctagt tcttcttgta accctgaggt gccagcgcgg ggagtgagga   7620

ggggtcaggg ggctaaggat gcaacctctg acgttctgcg ccttcctagg agagtcttac   7680

atgtgttgag atttcacaag caatgcgagt tgtaaaatac cagctctaca agaagctagg   7740

ctctgtgacg gcatagtttt cagtagcttt atcacaatat tcacaatgga gaattatatg   7800

acatggtagc agaaataggc ccttttatgt gttgcttcta ttttacctca aattgtagat   7860

atagggtaat caataaaatc catccatgcc tttcacacac taagt                   7905


<210>  4147
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  4147

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg 
            420                 425                 430


Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe 
        435                 440                 445


Ala 



<210>  4148
<211>  4466
<212>  DNA
<213>  Homo sapiens

<400>  4148
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2100

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2160

tttgaaattt gcttagattt gttgacagcg gtttcctgga gtgctgtctt gagaacgatt   2220

ctgaggaggc tcagcaagaa agagtgtttc agttgattgg gtgtgtctgt catggagaag   2280

gaactcaagc tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa   2340

acccggagtt cttgtatgtg gaaggcttgc cagaggggat tcccttccga agccctacct   2400

ggtttggaat tccacgactt gaaaggatcg tccgcgggag taataaaatc aagttcgttg   2460

ttaaaaaacc tgaactagtt atttcctact tgcctcctgg gatggctagt aaaataaaca   2520

ctaaagcttt gcagtccccc aaaagaccac gaagtcctgg gagtaattca aaggttcctg   2580

aaattgaggt caccgtggaa ggccctaata acaacaatcc tcaaacctca gctgttcgaa   2640

ccccgaccca gactaacggt tctaacgttc ccttcaagcc acgagggaga gagttttcct   2700

ttgaggcctg gaatgccaaa atcacggacc taaaacagaa agttgaaaat ctcttcaatg   2760

agaaatgtgg ggaagctctt ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg   2820

agtctttccc ggaagacttt tatgtggaag gcttacctga gggtgtgcca ttccgaagac   2880

catcgacttt tggcattccg aggctggaga agatactcag aaacaaagcc aaaattaagt   2940

tcatcattaa aaagcccgaa atgtttgaga cggcgattaa ggagagcacc tcctctaaga   3000

gccctcccag aaaaataaat tcatcaccca atgttaatac tactgcatca ggtgttgaag   3060

accttaacat cattcaggtg acaattccag atgatgataa tgaaagactc tcgaaagttg   3120

aaaaagctag acagctaaga gaacaagtga atgacctctt tagtcggaaa tttggtgaag   3180

ctattggtat gggttttcct gtgaaagttc cctacaggaa aatcacaatt aaccctggct   3240

gtgtggtggt tgatggcatg cccccggggg tgtccttcaa agcccccagc tacctggaaa   3300

tcagctccat gagaaggatc ttagactctg ccgagtttat caaattcacg gtcattagac   3360

catttccagg acttgtgatt aataaccagc tggttgatca gagtgagtca gaaggccccg   3420

tgatacaaga atcagctgaa ccaagccagt tggaagttcc agccacagaa gaaataaaag   3480

agactgatgg aagctctcag atcaagcaag aaccagaccc cacgtggtag acctcttccc   3540

tcctaggctt aaagtatcag tggttgagaa gagcttttcg gacctgttac taccccaagc   3600

tgtagccttg agttacggtg tttattttcc aatcaagtga agatatctcc tacttctcct   3660

actggaacat ctcagcttct gcagtgaaga aaaattcctg tgatagttca gttctttagt   3720

ttttctattt gaaaaaaaaa aatcatttaa atgatccttt gttcacggct ctccttaatg   3780

actgagtgaa cagttcctat ctgtatattt gactaaacct tttcctaagc tatctctcat   3840

ggttcctatg tttttttatc ataattaaaa gcaaaaccat ctggatcacc taacagtcag   3900

aggtcagtat ctcagcgtgt gaattataga ggaaatacag agagaacctc ttccactttt   3960

acttttcgtc caaataaaat gcatggtgta ccagaagttg aagatcgggt tgaggattgg   4020

ggctagctcg atgacactaa ggccccaaca tcgcgggacc tgctgtggcg cggattctta   4080

ggaacgctgt tctagccggc cccctctcca ggggtcgccg tggccggcat tatttcctag   4140

ttcttcttgt aaccctgagg tgccagcgcg gggagtgagg aggggtcagg gggctaagga   4200

tgcaacctct gacgttctgc gccttcctag gagagtctta catgtgttga gatttcacaa   4260

gcaatgcgag ttgtaaaata ccagctctac aagaagctag gctctgtgac ggcatagttt   4320

tcagtagctt tatcacaata ttcacaatgg agaattatat gacatggtag cagaaatagg   4380

cccttttatg tgttgcttct attttacctc aaattgtaga tatagggtaa tcaataaaat   4440

ccatccatgc ctttcacaca ctaagt                                        4466


<210>  4149
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  4149

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala 
            580


<210>  4150
<211>  5020
<212>  DNA
<213>  Homo sapiens

<400>  4150
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1920

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   1980

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttgt   2040

atgtggaagg cttgccagag gggattccct tccgaagccc tacctggttt ggaattccac   2100

gacttgaaag gatcgtccgc gggagtaata aaatcaagtt cgttgttaaa aaacctgaac   2160

tagttatttc ctacttgcct cctgggatgg ctagtaaaat aaacactaaa gctttgcagt   2220

cccccaaaag accacgaagt cctgggagta attcaaaggt tcctgaaatt gaggtcaccg   2280

tggaaggccc taataacaac aatcctcaaa cctcagctgt tcgaaccccg acccagacta   2340

acggttctaa cgttcccttc aagccacgag ggagagagtt ttcctttgag gcctggaatg   2400

ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt caatgagaaa tgtggggaag   2460

ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt atttgagtct ttcccggaag   2520

acttttatgt ggaaggctta cctgagggtg tgccattccg aagaccatcg acttttggca   2580

ttccgaggct ggagaagata ctcagaaaca aagccaaaat taagttcatc attaaaaagc   2640

ccgaaatgtt tgagacggcg attaaggaga gcacctcctc taagagccct cccagaaaaa   2700

taaattcatc acccaatgtt aatactactg catcaggtgt tgaagacctt aacatcattc   2760

aggtgacaat tccagatgat gataatgaaa gactctcgaa agttgaaaaa gctagacagc   2820

taagagaaca agtgaatgac ctctttagtc ggaaatttgg tgaagctatt ggtatgggtt   2880

ttcctgtgaa agttccctac aggaaaatca caattaaccc tggctgtgtg gtggttgatg   2940

gcatgccccc gggggtgtcc ttcaaagccc ccagctacct ggaaatcagc tccatgagaa   3000

ggatcttaga ctctgccgag tttatcaaat tcacggtcat tagaccattt ccaggacttg   3060

tgattaataa ccagctggtt gatcagagtg agtcagaagg ccccgtgata caagaatcag   3120

ctgaaccaag ccagttggaa gttccagcca cagaaggtaa aaggacctct tccctcctag   3180

ggtaaatcag cttctgtgtc agggatgctg tgtggtgtcc atctgaaccc cctgcatacg   3240

cgtagctaat gtgatctccc cactttcaca taagatggtg gccctgcctt cagggaatgt   3300

gggagccagg tgggagcctt cccggatatt taagctagaa gattctacag ggagattctc   3360

cttggatcaa tatatgtctc tcagtcaaag atgtaaaagc acttttgcct taaaaagaat   3420

gttctgtttc taaatagagt caacgttgtc ctcctcattg gaattcacta tgagtcagaa   3480

tcattagact gacttttttt tttccatagt aatagtattt tgcagagtct cacagagctg   3540

cagatctttt gttcatcttg cagagttaac aagtctgatc ctgttagtcc agatttctta   3600

aatttggcca agttataata ggagcagtag cttgagaccc gaagtcagga aactttgaca   3660

atggattttt ttttttaatc cagagacttg tactggaatt tgccttaccc tgtcagctca   3720

tggacttaag gtttcatccc gctttatgag tgcttctgaa tccaagtcat tgttacctga   3780

atttgcaaat taagttgtga tattcgtgac tgttaaattc ctgtaattag attaacctct   3840

ttgcttgctt gtttgttttc tctcctattt tagcttaaag tatcagtggt tgagaagagc   3900

ttttcggacc tgttactacc ccaagctgtg taatatactt gtataacaga aataccttct   3960

atacaaacct ttttttctac ttttagatag aaatgtctac tttttcagca gttctgtgaa   4020

ttaaagagca gagtgactgt gggtctggaa tggctggtgt acttgggaat gtactatcag   4080

gattttacag caatgctggg aaatgacagg gaaaatgaca ggaatgaatc tcaccagatt   4140

ttttatgtac tcagcagagc cttgagttac ggtgtttatt ttccaatcaa gtgaagatat   4200

ctcctacttc tcctactgga acatctcagc ttctgcagtg aagaaaaatt cctgtgatag   4260

ttcagttctt tagtttttct atttgaaaaa aaaaaatcat ttaaatgatc ctttgttcac   4320

ggctctcctt aatgactgag tgaacagttc ctatctgtat atttgactaa accttttcct   4380

aagctatctc tcatggttcc tatgtttttt tatcataatt aaaagcaaaa ccatctggat   4440

cacctaacag tcagaggtca gtatctcagc gtgtgaatta tagaggaaat acagagagaa   4500

cctcttccac ttttactttt cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc   4560

gggttgagga ttggggctag ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt   4620

ggcgcggatt cttaggaacg ctgttctagc cggccccctc tccaggggtc gccgtggccg   4680

gcattatttc ctagttcttc ttgtaaccct gaggtgccag cgcggggagt gaggaggggt   4740

cagggggcta aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg   4800

ttgagatttc acaagcaatg cgagttgtaa aataccagct ctacaagaag ctaggctctg   4860

tgacggcata gttttcagta gctttatcac aatattcaca atggagaatt atatgacatg   4920

gtagcagaaa taggcccttt tatgtgttgc ttctatttta cctcaaattg tagatatagg   4980

gtaatcaata aaatccatcc atgcctttca cacactaagt                         5020


<210>  4151
<211>  927
<212>  PRT
<213>  Homo sapiens

<400>  4151

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
            500                 505                 510


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
        515                 520                 525


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
    530                 535                 540


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
545                 550                 555                 560


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
                565                 570                 575


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
            580                 585                 590


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
        595                 600                 605


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
    610                 615                 620


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
625                 630                 635                 640


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
                645                 650                 655


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
            660                 665                 670


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
        675                 680                 685


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
    690                 695                 700


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
705                 710                 715                 720


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
                725                 730                 735


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
            740                 745                 750


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
        755                 760                 765


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
    770                 775                 780


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
785                 790                 795                 800


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
                805                 810                 815


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
            820                 825                 830


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
        835                 840                 845


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
    850                 855                 860


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
865                 870                 875                 880


Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser 
                885                 890                 895


Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu 
            900                 905                 910


Glu Val Pro Ala Thr Glu Gly Lys Arg Thr Ser Ser Leu Leu Gly 
        915                 920                 925


<210>  4152
<211>  7058
<212>  DNA
<213>  Homo sapiens

<400>  4152
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gtcaaagaag attggaatgt cagaattacc aagctacgga   1920

agcaagtgga agagattttt aatttgaaat ttgctcaagc tcttggactc accgaggcag   1980

taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgaaagga tcgtccgcgg   2040

gagtaataaa atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc   2100

tgggatggct agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc   2160

tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa   2220

tcctcaaacc tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa   2280

gccacgaggg agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca   2340

gaaagttgaa aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt   2400

gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc   2460

tgagggtgtg ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact   2520

cagaaacaaa gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat   2580

taaggagagc acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa   2640

tactactgca tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga   2700

taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct   2760

ctttagtcgg aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag   2820

gaaaatcaca attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt   2880

caaagccccc agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt   2940

tatcaaattc acggtcatta ggtaagtgag agtttcctgc ttagtcacag gagcgaatct   3000

ggagctcatg aggctgactc ttctaaaatg cagccacagg tagtcatcga atccggcttc   3060

ctatgctgtg caatcaacaa atcaaaataa cttgtgtcat cattagaatg tcagatgtgc   3120

ttctacgaac taagctgact cttttaattc tttggcaaag ggttggcaaa ctaggactgt   3180

ttgccaaatt caggctgcct cctattttta gagtcttcct gaaacacagc tacacccgta   3240

ttatccatgg ctgctttcct gtcacagtga gtaagtagct gggactgaga aggcatggcc   3300

tccaaagtct aaaatattta ctctctagca ctttgtagaa aaaccttagc taggcacagt   3360

ggctaacgcc tgtaatccca gcattttggg aggccaaggc aggcagatca cctgaggtca   3420

ggagttccag accagcctgg ccaacatggt gaaatcccat ctctacaaaa ataaaacagt   3480

tagctgggca tgatggcggg tgcctgtaat cccagctact cgggaggctg aggcaggata   3540

gtcgcttgaa cccaggaggt ggaggttgca atgagccaag atcatgccac tgcactccag   3600

cctggacgac agagtgagac tccatcacaa gaaaaaaaga actttgtcaa cctctgtctt   3660

agggcgcctt gtcacaggct tcgggtcaga cggattcaac cttgcatcag ccatttgtta   3720

gccaggtcac tctgttcttt gtctgtaaat gagattgatc gttgttccca ctgagagtgt   3780

cagctccttc ccgtagagca ggcatgatga ttgtactcac ctctgacacc attgtgagtg   3840

ccacattcct tcccacgtcc ttgtcactgt aagagatgcc cacctgagca ccaaccccag   3900

gttatcttcc cctttgtctt ccagcccccc agaaacagct acgactcaac ctacccaatc   3960

atttcatcat cagattgcca ctgtctctag ttcaggtctc ttgggactgg cactcagaaa   4020

tctcataata aatcctcttg aggcttctca tacactcgtc ttcttccaat cttctttccc   4080

tcaaaatctc atattttggt tccacttcac ccaccgtcat tctccatatc actcccagga   4140

gttaggcaaa aagccccttc cgttcttccg tatgttaaac ttagaatcac tctgttccct   4200

gctctgcgtt tctatttttt gtttttcctc catttactag tagcttaaca ctttctaaca   4260

gtgttcttat tattgatacg tatctatctc ttccataagc ttataaggtc acggataata   4320

cttctcattg tagtacgtaa atgacgtggg ctagatatga gttgaataaa cagttatacc   4380

tgtaaattct tacagagtga aaataaattg ttatacttta caatttgttt ctctctttag   4440

accatttcca ggacttgtga ttaataaccg tgagtatttt gtgaagtgtt ttgtttttgt   4500

tttttcctgg ggtctgacgt gtgtgcgtgt gagtgtgtat acatgcttaa cgtatatcac   4560

gttacttcac ctatgtcagt aaccaggcca aatacttgtt ttagccctca gtaaaaacac   4620

caggcacttc ctagttgtaa aattattcaa gcttcttaac ttcctatcct cgatgcactt   4680

aatcataaaa tggtaataat agcaccgatt ttgggggagt cgttccagta gatggaaagc   4740

atctggaaca ggtgtcagca agctcctgcc gacgtgtatg cataaagttt tattgaaacc   4800

accatcgtgt ccatttgttt atggcagaac tgagagatgg cagcagcaag tgtgtgcctg   4860

caaaacctaa aatatttact aattggctct gcaagaaaag agtttgcatc cccctaacct   4920

agaacagtgt ctagcctcta gtatgtgttt agcctacagt atgtgctcag cgaatacaat   4980

ctatatttat tactgctttt atgactgtta taattactgt gcttggattt cgttacaaag   5040

taagtcacaa tgtgcctgct tctgttagta tttcagcaca gtgcctggca cacatggggc   5100

tctcaaatat tgctgagcga gtgaacaaat gtcctttcaa ttccttaacg ttgatgtcat   5160

tttcaatagt attttgagcc aaacttaatt ttgcgagtgt gttttgtttt cttaacttta   5220

ttattaaaaa tgtataaaag tgaggccagg cgtggtggct cacgcctgta atcccagcag   5280

tttgggaggc tgaggcaggc ggatcagttg aggttgggag ttggagacca gcccgtccaa   5340

catggtgaaa gcctgtctct actaaaaata caaaaatcag ctgggtgtgg tggcgcgtgc   5400

ctgtaatccc agctactcag gaggctgagg caggagagtt gcttgaatcc tagaggtgga   5460

ggttgcagtg agctgagatc gtgccattgc actccagcct gggcaacaag agcaaaactc   5520

tgtcccaata aataaataaa taaaatgttc tcttttgttc ctgttcttgt gcggtagtgt   5580

ggtatagagt tttatggtaa ttactgtgaa ttagtgattc tgagggacat atcagaactc   5640

tgaggtttgt ttccttctca tcttgaggga aacagcaaat gtatgttaaa atgcttttcc   5700

aagggaacaa cacatcctta cattatttaa accaatctgc ttcattttca gagctggttg   5760

atcagagtga gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag   5820

ttccagccac agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag   5880

accccacgtg gtagacctct tccctcctag gcttaaagta tcagtggttg agaagagctt   5940

ttcggacctg ttactacccc aagctgtgta atatacttgt ataacagaaa taccttctat   6000

acaaaccttt ttttctactt ttagatagaa atgtctactt tttcagcagt tctgtgaatt   6060

aaagagcaga gtgactgtgg gtctggaatg gctggtgtac ttgggaatgt actatcagga   6120

ttttacagca atgctgggaa atgacaggga aaatgacagg aatgaatctc accagatttt   6180

ttatgtactc agcagagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct   6240

cctacttctc ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt   6300

cagttcttta gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg   6360

ctctccttaa tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa   6420

gctatctctc atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca   6480

cctaacagtc agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc   6540

tcttccactt ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg   6600

gttgaggatt ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg   6660

cgcggattct taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc   6720

attatttcct agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca   6780

gggggctaag gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt   6840

gagatttcac aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg   6900

acggcatagt tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt   6960

agcagaaata ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt   7020

aatcaataaa atccatccat gcctttcaca cactaagt                           7058


<210>  4153
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  4153

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
                485                 490                 495


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
            500                 505                 510


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
        515                 520                 525


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser 
    530                 535                 540


Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
545                 550                 555


<210>  4154
<211>  4166
<212>  DNA
<213>  Homo sapiens

<400>  4154
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagc   2040

tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc   2100

ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc ctacctggtt   2160

tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa   2220

aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa taaacactaa   2280

agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg ttcctgaaat   2340

tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg ttcgaacccc   2400

gacccagact aacggttcta acgttccctt caagccacga gggagagagt tttcctttga   2460

ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct tcaatgagaa   2520

atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc   2580

tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc gaagaccatc   2640

gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa ttaagttcat   2700

cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct ctaagagccc   2760

tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg ttgaagacct   2820

taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga aagttgaaaa   2880

agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg gtgaagctat   2940

tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc ctggctgtgt   3000

ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc tggaaatcag   3060

ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca ttagaccatt   3120

tccaggactt gtgattaata accagctggt tgatcagagt gagtcagaag gccccgtgat   3180

acaagaatca gctgaaccaa gccagttgga agttccagcc acagaagaaa taaaagagac   3240

tgatggaagc tctcagatca agcaagaacc agaccccacg tggtagacct cttccctcct   3300

aggagccttg agttacggtg tttattttcc aatcaagtga agatatctcc tacttctcct   3360

actggaacat ctcagcttct gcagtgaaga aaaattcctg tgatagttca gttctttagt   3420

ttttctattt gaaaaaaaaa aatcatttaa atgatccttt gttcacggct ctccttaatg   3480

actgagtgaa cagttcctat ctgtatattt gactaaacct tttcctaagc tatctctcat   3540

ggttcctatg tttttttatc ataattaaaa gcaaaaccat ctggatcacc taacagtcag   3600

aggtcagtat ctcagcgtgt gaattataga ggaaatacag agagaacctc ttccactttt   3660

acttttcgtc caaataaaat gcatggtgta ccagaagttg aagatcgggt tgaggattgg   3720

ggctagctcg atgacactaa ggccccaaca tcgcgggacc tgctgtggcg cggattctta   3780

ggaacgctgt tctagccggc cccctctcca ggggtcgccg tggccggcat tatttcctag   3840

ttcttcttgt aaccctgagg tgccagcgcg gggagtgagg aggggtcagg gggctaagga   3900

tgcaacctct gacgttctgc gccttcctag gagagtctta catgtgttga gatttcacaa   3960

gcaatgcgag ttgtaaaata ccagctctac aagaagctag gctctgtgac ggcatagttt   4020

tcagtagctt tatcacaata ttcacaatgg agaattatat gacatggtag cagaaatagg   4080

cccttttatg tgttgcttct attttacctc aaattgtaga tatagggtaa tcaataaaat   4140

ccatccatgc ctttcacaca ctaagt                                        4166


<210>  4155
<211>  954
<212>  PRT
<213>  Homo sapiens

<400>  4155

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly 
    530                 535                 540


Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro 
545                 550                 555                 560


Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser 
                565                 570                 575


Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser 
            580                 585                 590


Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr 
        595                 600                 605


Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser 
    610                 615                 620


Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile 
625                 630                 635                 640


Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala 
                645                 650                 655


Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro 
            660                 665                 670


Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp 
        675                 680                 685


Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala 
    690                 695                 700


Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser 
705                 710                 715                 720


Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe 
                725                 730                 735


Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg 
            740                 745                 750


Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu 
        755                 760                 765


Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile 
    770                 775                 780


Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu 
785                 790                 795                 800


Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser 
                805                 810                 815


Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe 
            820                 825                 830


Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val 
        835                 840                 845


Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly 
    850                 855                 860


Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser 
865                 870                 875                 880


Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val 
                885                 890                 895


Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln 
            900                 905                 910


Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln 
        915                 920                 925


Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser 
    930                 935                 940


Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  4156
<211>  4502
<212>  DNA
<213>  Homo sapiens

<400>  4156
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   2040

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2100

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2160

tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg tttggaattc   2220

cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg   2280

aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc   2340

agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca   2400

ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga   2460

ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga   2520

atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg   2580

aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg   2640

aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg   2700

gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa   2760

agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa   2820

aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca   2880

ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac   2940

agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg   3000

gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg   3060

atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga   3120

gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca tttccaggac   3180

ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat   3240

cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa   3300

gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc ctaggcttaa   3360

agtatcagtg gttgagaaga gcttttcgga cctgttacta ccccaagctg tgtaatatac   3420

ttgtataaca gaaatacctt ctatacaaac ctttttttct acttttagat agaaatgtct   3480

actttttcag cagttctgtg aattaaagag cagagtgact gtgggtctgg aatggctggt   3540

gtacttggga atgtactatc aggattttac agcaatgctg ggaaatgaca gggaaaatga   3600

caggaatgaa tctcaccaga ttttttatgt actcagcaga gccttgagtt acggtgttta   3660

ttttccaatc aagtgaagat atctcctact tctcctactg gaacatctca gcttctgcag   3720

tgaagaaaaa ttcctgtgat agttcagttc tttagttttt ctatttgaaa aaaaaaaatc   3780

atttaaatga tcctttgttc acggctctcc ttaatgactg agtgaacagt tcctatctgt   3840

atatttgact aaaccttttc ctaagctatc tctcatggtt cctatgtttt tttatcataa   3900

ttaaaagcaa aaccatctgg atcacctaac agtcagaggt cagtatctca gcgtgtgaat   3960

tatagaggaa atacagagag aacctcttcc acttttactt ttcgtccaaa taaaatgcat   4020

ggtgtaccag aagttgaaga tcgggttgag gattggggct agctcgatga cactaaggcc   4080

ccaacatcgc gggacctgct gtggcgcgga ttcttaggaa cgctgttcta gccggccccc   4140

tctccagggg tcgccgtggc cggcattatt tcctagttct tcttgtaacc ctgaggtgcc   4200

agcgcgggga gtgaggaggg gtcagggggc taaggatgca acctctgacg ttctgcgcct   4260

tcctaggaga gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt aaaataccag   4320

ctctacaaga agctaggctc tgtgacggca tagttttcag tagctttatc acaatattca   4380

caatggagaa ttatatgaca tggtagcaga aataggccct tttatgtgtt gcttctattt   4440

tacctcaaat tgtagatata gggtaatcaa taaaatccat ccatgccttt cacacactaa   4500

gt                                                                  4502


<210>  4157
<211>  978
<212>  PRT
<213>  Homo sapiens

<400>  4157

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu 
            580                 585                 590


Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg 
        595                 600                 605


Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys 
    610                 615                 620


Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys 
625                 630                 635                 640


Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly 
                645                 650                 655


Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn 
            660                 665                 670


Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn 
        675                 680                 685


Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu 
    690                 695                 700


Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu 
705                 710                 715                 720


Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys 
                725                 730                 735


Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu 
            740                 745                 750


Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile 
        755                 760                 765


Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile 
    770                 775                 780


Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser 
785                 790                 795                 800


Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr 
                805                 810                 815


Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro 
            820                 825                 830


Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu 
        835                 840                 845


Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile 
    850                 855                 860


Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn 
865                 870                 875                 880


Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys 
                885                 890                 895


Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser 
            900                 905                 910


Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val 
        915                 920                 925


Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile 
    930                 935                 940


Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu 
945                 950                 955                 960


Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro 
                965                 970                 975


Thr Trp 



<210>  4158
<211>  7044
<212>  DNA
<213>  Homo sapiens

<400>  4158
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agctcaagct cttggactca ccgaggcagt aaaagtacca tatcctgtgt   1920

ttgaatcaaa cccggagttc ttgtatgtgg aaggcttgcc agaggggatt cccttccgaa   1980

gccctacctg gtttggaatt ccacgacttg aaaggatcgt ccgcgggagt aataaaatca   2040

agttcgttgt taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta   2100

aaataaacac taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa   2160

aggttcctga aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag   2220

ctgttcgaac cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag   2280

agttttcctt tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc   2340

tcttcaatga gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg   2400

cgttatttga gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat   2460

tccgaagacc atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca   2520

aaattaagtt catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct   2580

cctctaagag ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag   2640

gtgttgaaga ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct   2700

cgaaagttga aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat   2760

ttggtgaagc tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta   2820

accctggctg tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct   2880

acctggaaat cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg   2940

tcattaggta agtgagagtt tcctgcttag tcacaggagc gaatctggag ctcatgaggc   3000

tgactcttct aaaatgcagc cacaggtagt catcgaatcc ggcttcctat gctgtgcaat   3060

caacaaatca aaataacttg tgtcatcatt agaatgtcag atgtgcttct acgaactaag   3120

ctgactcttt taattctttg gcaaagggtt ggcaaactag gactgtttgc caaattcagg   3180

ctgcctccta tttttagagt cttcctgaaa cacagctaca cccgtattat ccatggctgc   3240

tttcctgtca cagtgagtaa gtagctggga ctgagaaggc atggcctcca aagtctaaaa   3300

tatttactct ctagcacttt gtagaaaaac cttagctagg cacagtggct aacgcctgta   3360

atcccagcat tttgggaggc caaggcaggc agatcacctg aggtcaggag ttccagacca   3420

gcctggccaa catggtgaaa tcccatctct acaaaaataa aacagttagc tgggcatgat   3480

ggcgggtgcc tgtaatccca gctactcggg aggctgaggc aggatagtcg cttgaaccca   3540

ggaggtggag gttgcaatga gccaagatca tgccactgca ctccagcctg gacgacagag   3600

tgagactcca tcacaagaaa aaaagaactt tgtcaacctc tgtcttaggg cgccttgtca   3660

caggcttcgg gtcagacgga ttcaaccttg catcagccat ttgttagcca ggtcactctg   3720

ttctttgtct gtaaatgaga ttgatcgttg ttcccactga gagtgtcagc tccttcccgt   3780

agagcaggca tgatgattgt actcacctct gacaccattg tgagtgccac attccttccc   3840

acgtccttgt cactgtaaga gatgcccacc tgagcaccaa ccccaggtta tcttcccctt   3900

tgtcttccag ccccccagaa acagctacga ctcaacctac ccaatcattt catcatcaga   3960

ttgccactgt ctctagttca ggtctcttgg gactggcact cagaaatctc ataataaatc   4020

ctcttgaggc ttctcataca ctcgtcttct tccaatcttc tttccctcaa aatctcatat   4080

tttggttcca cttcacccac cgtcattctc catatcactc ccaggagtta ggcaaaaagc   4140

cccttccgtt cttccgtatg ttaaacttag aatcactctg ttccctgctc tgcgtttcta   4200

ttttttgttt ttcctccatt tactagtagc ttaacacttt ctaacagtgt tcttattatt   4260

gatacgtatc tatctcttcc ataagcttat aaggtcacgg ataatacttc tcattgtagt   4320

acgtaaatga cgtgggctag atatgagttg aataaacagt tatacctgta aattcttaca   4380

gagtgaaaat aaattgttat actttacaat ttgtttctct ctttagacca tttccaggac   4440

ttgtgattaa taaccgtgag tattttgtga agtgttttgt ttttgttttt tcctggggtc   4500

tgacgtgtgt gcgtgtgagt gtgtatacat gcttaacgta tatcacgtta cttcacctat   4560

gtcagtaacc aggccaaata cttgttttag ccctcagtaa aaacaccagg cacttcctag   4620

ttgtaaaatt attcaagctt cttaacttcc tatcctcgat gcacttaatc ataaaatggt   4680

aataatagca ccgattttgg gggagtcgtt ccagtagatg gaaagcatct ggaacaggtg   4740

tcagcaagct cctgccgacg tgtatgcata aagttttatt gaaaccacca tcgtgtccat   4800

ttgtttatgg cagaactgag agatggcagc agcaagtgtg tgcctgcaaa acctaaaata   4860

tttactaatt ggctctgcaa gaaaagagtt tgcatccccc taacctagaa cagtgtctag   4920

cctctagtat gtgtttagcc tacagtatgt gctcagcgaa tacaatctat atttattact   4980

gcttttatga ctgttataat tactgtgctt ggatttcgtt acaaagtaag tcacaatgtg   5040

cctgcttctg ttagtatttc agcacagtgc ctggcacaca tggggctctc aaatattgct   5100

gagcgagtga acaaatgtcc tttcaattcc ttaacgttga tgtcattttc aatagtattt   5160

tgagccaaac ttaattttgc gagtgtgttt tgttttctta actttattat taaaaatgta   5220

taaaagtgag gccaggcgtg gtggctcacg cctgtaatcc cagcagtttg ggaggctgag   5280

gcaggcggat cagttgaggt tgggagttgg agaccagccc gtccaacatg gtgaaagcct   5340

gtctctacta aaaatacaaa aatcagctgg gtgtggtggc gcgtgcctgt aatcccagct   5400

actcaggagg ctgaggcagg agagttgctt gaatcctaga ggtggaggtt gcagtgagct   5460

gagatcgtgc cattgcactc cagcctgggc aacaagagca aaactctgtc ccaataaata   5520

aataaataaa atgttctctt ttgttcctgt tcttgtgcgg tagtgtggta tagagtttta   5580

tggtaattac tgtgaattag tgattctgag ggacatatca gaactctgag gtttgtttcc   5640

ttctcatctt gagggaaaca gcaaatgtat gttaaaatgc ttttccaagg gaacaacaca   5700

tccttacatt atttaaacca atctgcttca ttttcagagc tggttgatca gagtgagtca   5760

gaaggccccg tgatacaaga atcagctgaa ccaagccagt tggaagttcc agccacagaa   5820

gaaataaaag agactgatgg aagctctcag atcaagcaag aaccagaccc cacgtggtag   5880

acctcttccc tcctaggctt aaagtatcag tggttgagaa gagcttttcg gacctgttac   5940

taccccaagc tgtgtaatat acttgtataa cagaaatacc ttctatacaa accttttttt   6000

ctacttttag atagaaatgt ctactttttc agcagttctg tgaattaaag agcagagtga   6060

ctgtgggtct ggaatggctg gtgtacttgg gaatgtacta tcaggatttt acagcaatgc   6120

tgggaaatga cagggaaaat gacaggaatg aatctcacca gattttttat gtactcagca   6180

gagccttgag ttacggtgtt tattttccaa tcaagtgaag atatctccta cttctcctac   6240

tggaacatct cagcttctgc agtgaagaaa aattcctgtg atagttcagt tctttagttt   6300

ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt tcacggctct ccttaatgac   6360

tgagtgaaca gttcctatct gtatatttga ctaaaccttt tcctaagcta tctctcatgg   6420

ttcctatgtt tttttatcat aattaaaagc aaaaccatct ggatcaccta acagtcagag   6480

gtcagtatct cagcgtgtga attatagagg aaatacagag agaacctctt ccacttttac   6540

ttttcgtcca aataaaatgc atggtgtacc agaagttgaa gatcgggttg aggattgggg   6600

ctagctcgat gacactaagg ccccaacatc gcgggacctg ctgtggcgcg gattcttagg   6660

aacgctgttc tagccggccc cctctccagg ggtcgccgtg gccggcatta tttcctagtt   6720

cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg gctaaggatg   6780

caacctctga cgttctgcgc cttcctagga gagtcttaca tgtgttgaga tttcacaagc   6840

aatgcgagtt gtaaaatacc agctctacaa gaagctaggc tctgtgacgg catagttttc   6900

agtagcttta tcacaatatt cacaatggag aattatatga catggtagca gaaataggcc   6960

cttttatgtg ttgcttctat tttacctcaa attgtagata tagggtaatc aataaaatcc   7020

atccatgcct ttcacacact aagt                                          7044


<210>  4159
<211>  788
<212>  PRT
<213>  Homo sapiens

<400>  4159

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala 
            420                 425                 430


Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser 
        435                 440                 445


Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
    450                 455                 460


Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg 
465                 470                 475                 480


Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile 
                485                 490                 495


Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu 
            500                 505                 510


Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro 
        515                 520                 525


Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr 
    530                 535                 540


Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe 
545                 550                 555                 560


Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile 
                565                 570                 575


Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly 
            580                 585                 590


Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe 
        595                 600                 605


Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val 
    610                 615                 620


Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile 
625                 630                 635                 640


Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met 
                645                 650                 655


Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg 
            660                 665                 670


Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu 
        675                 680                 685


Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg 
    690                 695                 700


Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp 
705                 710                 715                 720


Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val 
                725                 730                 735


Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val 
            740                 745                 750


Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu 
        755                 760                 765


Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe 
    770                 775                 780


Thr Val Ile Arg 
785


<210>  4160
<211>  5282
<212>  DNA
<213>  Homo sapiens

<400>  4160
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   2040

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   2100

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2160

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2220

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2280

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2340

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2400

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2460

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2520

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2580

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2640

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2700

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2760

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2820

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2880

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2940

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   3000

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   3060

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3120

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3180

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3240

ttcacggtca ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt   3300

gagtcagaag gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc   3360

acagaagaaa taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg   3420

tggtagacct cttccctcct agggtaaatc agcttctgtg tcagggatgc tgtgtggtgt   3480

ccatctgaac cccctgcata cgcgtagcta atgtgatctc cccactttca cataagatgg   3540

tggccctgcc ttcagggaat gtgggagcca ggtgggagcc ttcccggata tttaagctag   3600

aagattctac agggagattc tccttggatc aatatatgtc tctcagtcaa agatgtaaaa   3660

gcacttttgc cttaaaaaga atgttctgtt tctaaataga gtcaacgttg tcctcctcat   3720

tggaattcac tatgagtcag aatcattaga ctgacttttt tttttccata gtaatagtat   3780

tttgcagagt ctcacagagc tgcagatctt ttgttcatct tgcagagtta acaagtctga   3840

tcctgttagt ccagatttct taaatttggc caagttataa taggagcagt agcttgagac   3900

ccgaagtcag gaaactttga caatggattt ttttttttaa tccagagact tgtactggaa   3960

tttgccttac cctgtcagct catggactta aggtttcatc ccgctttatg agtgcttctg   4020

aatccaagtc attgttacct gaatttgcaa attaagttgt gatattcgtg actgttaaat   4080

tcctgtaatt agattaacct ctttgcttgc ttgtttgttt tctctcctat tttagcttaa   4140

agtatcagtg gttgagaaga gcttttcgga cctgttacta ccccaagctg tgtaatatac   4200

ttgtataaca gaaatacctt ctatacaaac ctttttttct acttttagat agaaatgtct   4260

actttttcag cagttctgtg aattaaagag cagagtgact gtgggtctgg aatggctggt   4320

gtacttggga atgtactatc aggattttac agcaatgctg ggaaatgaca gggaaaatga   4380

caggaatgaa tctcaccaga ttttttatgt actcagcaga gccttgagtt acggtgttta   4440

ttttccaatc aagtgaagat atctcctact tctcctactg gaacatctca gcttctgcag   4500

tgaagaaaaa ttcctgtgat agttcagttc tttagttttt ctatttgaaa aaaaaaaatc   4560

atttaaatga tcctttgttc acggctctcc ttaatgactg agtgaacagt tcctatctgt   4620

atatttgact aaaccttttc ctaagctatc tctcatggtt cctatgtttt tttatcataa   4680

ttaaaagcaa aaccatctgg atcacctaac agtcagaggt cagtatctca gcgtgtgaat   4740

tatagaggaa atacagagag aacctcttcc acttttactt ttcgtccaaa taaaatgcat   4800

ggtgtaccag aagttgaaga tcgggttgag gattggggct agctcgatga cactaaggcc   4860

ccaacatcgc gggacctgct gtggcgcgga ttcttaggaa cgctgttcta gccggccccc   4920

tctccagggg tcgccgtggc cggcattatt tcctagttct tcttgtaacc ctgaggtgcc   4980

agcgcgggga gtgaggaggg gtcagggggc taaggatgca acctctgacg ttctgcgcct   5040

tcctaggaga gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt aaaataccag   5100

ctctacaaga agctaggctc tgtgacggca tagttttcag tagctttatc acaatattca   5160

caatggagaa ttatatgaca tggtagcaga aataggccct tttatgtgtt gcttctattt   5220

tacctcaaat tgtagatata gggtaatcaa taaaatccat ccatgccttt cacacactaa   5280

gt                                                                  5282


<210>  4161
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  4161

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
465                 470                 475                 480


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
                485                 490                 495


<210>  4162
<211>  5035
<212>  DNA
<213>  Homo sapiens

<400>  4162
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agctcaagct cttggactca ccgaggcagt aaaagtacca tatcctgtgt   1980

ttgaatcaaa cccggagttc ttgtatgtgg aaggcttgcc agaggggatt cccttccgaa   2040

gccctacctg gtttggaatt ccacgacttg aaaggatcgt ccgcgggagt aataaaatca   2100

agttcgttgt taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta   2160

aaataaacac taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa   2220

aggttcctga aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag   2280

ctgttcgaac cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag   2340

agttttcctt tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc   2400

tcttcaatga gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg   2460

cgttatttga gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat   2520

tccgaagacc atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca   2580

aaattaagtt catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct   2640

cctctaagag ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag   2700

gtgttgaaga ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct   2760

cgaaagttga aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat   2820

ttggtgaagc tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta   2880

accctggctg tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct   2940

acctggaaat cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg   3000

tcattagacc atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag   3060

aaggccccgt gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag   3120

aaataaaaga gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga   3180

cctcttccct cctagggtaa atcagcttct gtgtcaggga tgctgtgtgg tgtccatctg   3240

aaccccctgc atacgcgtag ctaatgtgat ctccccactt tcacataaga tggtggccct   3300

gccttcaggg aatgtgggag ccaggtggga gccttcccgg atatttaagc tagaagattc   3360

tacagggaga ttctccttgg atcaatatat gtctctcagt caaagatgta aaagcacttt   3420

tgccttaaaa agaatgttct gtttctaaat agagtcaacg ttgtcctcct cattggaatt   3480

cactatgagt cagaatcatt agactgactt ttttttttcc atagtaatag tattttgcag   3540

agtctcacag agctgcagat cttttgttca tcttgcagag ttaacaagtc tgatcctgtt   3600

agtccagatt tcttaaattt ggccaagtta taataggagc agtagcttga gacccgaagt   3660

caggaaactt tgacaatgga tttttttttt taatccagag acttgtactg gaatttgcct   3720

taccctgtca gctcatggac ttaaggtttc atcccgcttt atgagtgctt ctgaatccaa   3780

gtcattgtta cctgaatttg caaattaagt tgtgatattc gtgactgtta aattcctgta   3840

attagattaa cctctttgct tgcttgtttg ttttctctcc tattttagct taaagtatca   3900

gtggttgaga agagcttttc ggacctgtta ctaccccaag ctgtgtaata tacttgtata   3960

acagaaatac cttctataca aacctttttt tctactttta gatagaaatg tctacttttt   4020

cagcagttct gtgaattaaa gagcagagtg actgtgggtc tggaatggct ggtgtacttg   4080

ggaatgtact atcaggattt tacagcaatg ctgggaaatg acagggaaaa tgacaggaat   4140

gaatctcacc agatttttta tgtactcagc agagccttga gttacggtgt ttattttcca   4200

atcaagtgaa gatatctcct acttctccta ctggaacatc tcagcttctg cagtgaagaa   4260

aaattcctgt gatagttcag ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa   4320

tgatcctttg ttcacggctc tccttaatga ctgagtgaac agttcctatc tgtatatttg   4380

actaaacctt ttcctaagct atctctcatg gttcctatgt ttttttatca taattaaaag   4440

caaaaccatc tggatcacct aacagtcaga ggtcagtatc tcagcgtgtg aattatagag   4500

gaaatacaga gagaacctct tccactttta cttttcgtcc aaataaaatg catggtgtac   4560

cagaagttga agatcgggtt gaggattggg gctagctcga tgacactaag gccccaacat   4620

cgcgggacct gctgtggcgc ggattcttag gaacgctgtt ctagccggcc ccctctccag   4680

gggtcgccgt ggccggcatt atttcctagt tcttcttgta accctgaggt gccagcgcgg   4740

ggagtgagga ggggtcaggg ggctaaggat gcaacctctg acgttctgcg ccttcctagg   4800

agagtcttac atgtgttgag atttcacaag caatgcgagt tgtaaaatac cagctctaca   4860

agaagctagg ctctgtgacg gcatagtttt cagtagcttt atcacaatat tcacaatgga   4920

gaattatatg acatggtagc agaaataggc ccttttatgt gttgcttcta ttttacctca   4980

aattgtagat atagggtaat caataaaatc catccatgcc tttcacacac taagt        5035


<210>  4163
<211>  864
<212>  PRT
<213>  Homo sapiens

<400>  4163

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro 
    450                 455                 460


Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu 
465                 470                 475                 480


Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu 
                485                 490                 495


Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro 
            500                 505                 510


Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn 
        515                 520                 525


Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn 
    530                 535                 540


Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn 
545                 550                 555                 560


Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser 
                565                 570                 575


Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp 
            580                 585                 590


Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn 
        595                 600                 605


Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro 
    610                 615                 620


Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu 
625                 630                 635                 640


Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg 
                645                 650                 655


Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys 
            660                 665                 670


Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys 
        675                 680                 685


Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala 
    690                 695                 700


Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp 
705                 710                 715                 720


Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu 
                725                 730                 735


Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met 
            740                 745                 750


Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly 
        755                 760                 765


Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro 
    770                 775                 780


Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu 
785                 790                 795                 800


Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn 
                805                 810                 815


Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu 
            820                 825                 830


Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys 
        835                 840                 845


Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
    850                 855                 860


<210>  4164
<211>  4554
<212>  DNA
<213>  Homo sapiens

<400>  4164
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   1980

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gcttagattt   2040

gttgacagcg gtttcctgga gtgctgtctt gagaacgatt ctgaggaggc tcagcaagaa   2100

agagtgtttc agttgattgg gtgtgtctgt catggagaag gaactcaagc tcttggactc   2160

accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgtatgtg   2220

gaaggcttgc cagaggggat tcccttccga agccctacct ggtttggaat tccacgactt   2280

gaaaggatcg tccgcgggag taataaaatc aagttcgttg ttaaaaaacc tgaactagtt   2340

atttcctact tgcctcctgg gatggctagt aaaataaaca ctaaagcttt gcagtccccc   2400

aaaagaccac gaagtcctgg gagtaattca aaggttcctg aaattgaggt caccgtggaa   2460

ggccctaata acaacaatcc tcaaacctca gctgttcgaa ccccgaccca gactaacggt   2520

tctaacgttc ccttcaagcc acgagggaga gagttttcct ttgaggcctg gaatgccaaa   2580

atcacggacc taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg ggaagctctt   2640

ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg agtctttccc ggaagacttt   2700

tatgtggaag gcttacctga gggtgtgcca ttccgaagac catcgacttt tggcattccg   2760

aggctggaga agatactcag aaacaaagcc aaaattaagt tcatcattaa aaagcccgaa   2820

atgtttgaga cggcgattaa ggagagcacc tcctctaaga gccctcccag aaaaataaat   2880

tcatcaccca atgttaatac tactgcatca ggtgttgaag accttaacat cattcaggtg   2940

acaattccag atgatgataa tgaaagactc tcgaaagttg aaaaagctag acagctaaga   3000

gaacaagtga atgacctctt tagtcggaaa tttggtgaag ctattggtat gggttttcct   3060

gtgaaagttc cctacaggaa aatcacaatt aaccctggct gtgtggtggt tgatggcatg   3120

cccccggggg tgtccttcaa agcccccagc tacctggaaa tcagctccat gagaaggatc   3180

ttagactctg ccgagtttat caaattcacg gtcattagac catttccagg acttgtgatt   3240

aataaccagc tggttgatca gagtgagtca gaaggccccg tgatacaaga atcagctgaa   3300

ccaagccagt tggaagttcc agccacagaa gaaataaaag agactgatgg aagctctcag   3360

atcaagcaag aaccagaccc cacgtggtag acctcttccc tcctaggctt aaagtatcag   3420

tggttgagaa gagcttttcg gacctgttac taccccaagc tgtgtaatat acttgtataa   3480

cagaaatacc ttctatacaa accttttttt ctacttttag atagaaatgt ctactttttc   3540

agcagttctg tgaattaaag agcagagtga ctgtgggtct ggaatggctg gtgtacttgg   3600

gaatgtacta tcaggatttt acagcaatgc tgggaaatga cagggaaaat gacaggaatg   3660

aatctcacca gattttttat gtactcagca gagccttgag ttacggtgtt tattttccaa   3720

tcaagtgaag atatctccta cttctcctac tggaacatct cagcttctgc agtgaagaaa   3780

aattcctgtg atagttcagt tctttagttt ttctatttga aaaaaaaaaa tcatttaaat   3840

gatcctttgt tcacggctct ccttaatgac tgagtgaaca gttcctatct gtatatttga   3900

ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt tttttatcat aattaaaagc   3960

aaaaccatct ggatcaccta acagtcagag gtcagtatct cagcgtgtga attatagagg   4020

aaatacagag agaacctctt ccacttttac ttttcgtcca aataaaatgc atggtgtacc   4080

agaagttgaa gatcgggttg aggattgggg ctagctcgat gacactaagg ccccaacatc   4140

gcgggacctg ctgtggcgcg gattcttagg aacgctgttc tagccggccc cctctccagg   4200

ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa ccctgaggtg ccagcgcggg   4260

gagtgaggag gggtcagggg gctaaggatg caacctctga cgttctgcgc cttcctagga   4320

gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc agctctacaa   4380

gaagctaggc tctgtgacgg catagttttc agtagcttta tcacaatatt cacaatggag   4440

aattatatga catggtagca gaaataggcc cttttatgtg ttgcttctat tttacctcaa   4500

attgtagata tagggtaatc aataaaatcc atccatgcct ttcacacact aagt         4554


<210>  4165
<211>  544
<212>  PRT
<213>  Homo sapiens

<400>  4165

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile 
        515                 520                 525


Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  4166
<211>  4634
<212>  DNA
<213>  Homo sapiens

<400>  4166
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2040

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2100

tttgaaattt gcttagattt gttgacagcg gtttcctgga gtgctgtctt gagaacgatt   2160

ctgaggaggc tcagcaagaa agagtgtttc agttgattgg gtgtgtctgt catggagaag   2220

gaactcaagc tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa   2280

acccggagtt cttgtatgtg gaaggcttgc cagaggggat tcccttccga agccctacct   2340

ggtttggaat tccacgactt gaaaggatcg tccgcgggag taataaaatc aagttcgttg   2400

ttaaaaaacc tgaactagtt atttcctact tgcctcctgg gatggctagt aaaataaaca   2460

ctaaagcttt gcagtccccc aaaagaccac gaagtcctgg gagtaattca aaggttcctg   2520

aaattgaggt caccgtggaa ggccctaata acaacaatcc tcaaacctca gctgttcgaa   2580

ccccgaccca gactaacggt tctaacgttc ccttcaagcc acgagggaga gagttttcct   2640

ttgaggcctg gaatgccaaa atcacggacc taaaacagaa agttgaaaat ctcttcaatg   2700

agaaatgtgg ggaagctctt ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg   2760

agtctttccc ggaagacttt tatgtggaag gcttacctga gggtgtgcca ttccgaagac   2820

catcgacttt tggcattccg aggctggaga agatactcag aaacaaagcc aaaattaagt   2880

tcatcattaa aaagcccgaa atgtttgaga cggcgattaa ggagagcacc tcctctaaga   2940

gccctcccag aaaaataaat tcatcaccca atgttaatac tactgcatca ggtgttgaag   3000

accttaacat cattcaggtg acaattccag atgatgataa tgaaagactc tcgaaagttg   3060

aaaaagctag acagctaaga gaacaagtga atgacctctt tagtcggaaa tttggtgaag   3120

ctattggtat gggttttcct gtgaaagttc cctacaggaa aatcacaatt aaccctggct   3180

gtgtggtggt tgatggcatg cccccggggg tgtccttcaa agcccccagc tacctggaaa   3240

tcagctccat gagaaggatc ttagactctg ccgagtttat caaattcacg gtcattagac   3300

catttccagg acttgtgatt aataaccagc tggttgatca gagtgagtca gaaggccccg   3360

tgatacaaga atcagctgaa ccaagccagt tggaagttcc agccacagaa gaaataaaag   3420

agactgatgg aagctctcag atcaagcaag aaccagaccc cacgtggtag acctcttccc   3480

tcctaggctt aaagtatcag tggttgagaa gagcttttcg gacctgttac taccccaagc   3540

tgtgtaatat acttgtataa cagaaatacc ttctatacaa accttttttt ctacttttag   3600

atagaaatgt ctactttttc agcagttctg tgaattaaag agcagagtga ctgtgggtct   3660

ggaatggctg gtgtacttgg gaatgtacta tcaggatttt acagcaatgc tgggaaatga   3720

cagggaaaat gacaggaatg aatctcacca gattttttat gtactcagca gagccttgag   3780

ttacggtgtt tattttccaa tcaagtgaag atatctccta cttctcctac tggaacatct   3840

cagcttctgc agtgaagaaa aattcctgtg atagttcagt tctttagttt ttctatttga   3900

aaaaaaaaaa tcatttaaat gatcctttgt tcacggctct ccttaatgac tgagtgaaca   3960

gttcctatct gtatatttga ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt   4020

tttttatcat aattaaaagc aaaaccatct ggatcaccta acagtcagag gtcagtatct   4080

cagcgtgtga attatagagg aaatacagag agaacctctt ccacttttac ttttcgtcca   4140

aataaaatgc atggtgtacc agaagttgaa gatcgggttg aggattgggg ctagctcgat   4200

gacactaagg ccccaacatc gcgggacctg ctgtggcgcg gattcttagg aacgctgttc   4260

tagccggccc cctctccagg ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa   4320

ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg gctaaggatg caacctctga   4380

cgttctgcgc cttcctagga gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt   4440

gtaaaatacc agctctacaa gaagctaggc tctgtgacgg catagttttc agtagcttta   4500

tcacaatatt cacaatggag aattatatga catggtagca gaaataggcc cttttatgtg   4560

ttgcttctat tttacctcaa attgtagata tagggtaatc aataaaatcc atccatgcct   4620

ttcacacact aagt                                                     4634


<210>  4167
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  4167

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala 



<210>  4168
<211>  7963
<212>  DNA
<213>  Homo sapiens

<400>  4168
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagc   2100

tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc   2160

ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc ctacctggtt   2220

tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa   2280

aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa taaacactaa   2340

agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg ttcctgaaat   2400

tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg ttcgaacccc   2460

gacccagact aacggttcta acgttccctt caagccacga gggagagagt tttcctttga   2520

ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct tcaatgagaa   2580

atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc   2640

tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc gaagaccatc   2700

gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa ttaagttcat   2760

cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct ctaagagccc   2820

tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg ttgaagacct   2880

taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga aagttgaaaa   2940

agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg gtgaagctat   3000

tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc ctggctgtgt   3060

ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc tggaaatcag   3120

ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca ttaggtaagt   3180

gagagtttcc tgcttagtca caggagcgaa tctggagctc atgaggctga ctcttctaaa   3240

atgcagccac aggtagtcat cgaatccggc ttcctatgct gtgcaatcaa caaatcaaaa   3300

taacttgtgt catcattaga atgtcagatg tgcttctacg aactaagctg actcttttaa   3360

ttctttggca aagggttggc aaactaggac tgtttgccaa attcaggctg cctcctattt   3420

ttagagtctt cctgaaacac agctacaccc gtattatcca tggctgcttt cctgtcacag   3480

tgagtaagta gctgggactg agaaggcatg gcctccaaag tctaaaatat ttactctcta   3540

gcactttgta gaaaaacctt agctaggcac agtggctaac gcctgtaatc ccagcatttt   3600

gggaggccaa ggcaggcaga tcacctgagg tcaggagttc cagaccagcc tggccaacat   3660

ggtgaaatcc catctctaca aaaataaaac agttagctgg gcatgatggc gggtgcctgt   3720

aatcccagct actcgggagg ctgaggcagg atagtcgctt gaacccagga ggtggaggtt   3780

gcaatgagcc aagatcatgc cactgcactc cagcctggac gacagagtga gactccatca   3840

caagaaaaaa agaactttgt caacctctgt cttagggcgc cttgtcacag gcttcgggtc   3900

agacggattc aaccttgcat cagccatttg ttagccaggt cactctgttc tttgtctgta   3960

aatgagattg atcgttgttc ccactgagag tgtcagctcc ttcccgtaga gcaggcatga   4020

tgattgtact cacctctgac accattgtga gtgccacatt ccttcccacg tccttgtcac   4080

tgtaagagat gcccacctga gcaccaaccc caggttatct tcccctttgt cttccagccc   4140

cccagaaaca gctacgactc aacctaccca atcatttcat catcagattg ccactgtctc   4200

tagttcaggt ctcttgggac tggcactcag aaatctcata ataaatcctc ttgaggcttc   4260

tcatacactc gtcttcttcc aatcttcttt ccctcaaaat ctcatatttt ggttccactt   4320

cacccaccgt cattctccat atcactccca ggagttaggc aaaaagcccc ttccgttctt   4380

ccgtatgtta aacttagaat cactctgttc cctgctctgc gtttctattt tttgtttttc   4440

ctccatttac tagtagctta acactttcta acagtgttct tattattgat acgtatctat   4500

ctcttccata agcttataag gtcacggata atacttctca ttgtagtacg taaatgacgt   4560

gggctagata tgagttgaat aaacagttat acctgtaaat tcttacagag tgaaaataaa   4620

ttgttatact ttacaatttg tttctctctt tagaccattt ccaggacttg tgattaataa   4680

ccgtgagtat tttgtgaagt gttttgtttt tgttttttcc tggggtctga cgtgtgtgcg   4740

tgtgagtgtg tatacatgct taacgtatat cacgttactt cacctatgtc agtaaccagg   4800

ccaaatactt gttttagccc tcagtaaaaa caccaggcac ttcctagttg taaaattatt   4860

caagcttctt aacttcctat cctcgatgca cttaatcata aaatggtaat aatagcaccg   4920

attttggggg agtcgttcca gtagatggaa agcatctgga acaggtgtca gcaagctcct   4980

gccgacgtgt atgcataaag ttttattgaa accaccatcg tgtccatttg tttatggcag   5040

aactgagaga tggcagcagc aagtgtgtgc ctgcaaaacc taaaatattt actaattggc   5100

tctgcaagaa aagagtttgc atccccctaa cctagaacag tgtctagcct ctagtatgtg   5160

tttagcctac agtatgtgct cagcgaatac aatctatatt tattactgct tttatgactg   5220

ttataattac tgtgcttgga tttcgttaca aagtaagtca caatgtgcct gcttctgtta   5280

gtatttcagc acagtgcctg gcacacatgg ggctctcaaa tattgctgag cgagtgaaca   5340

aatgtccttt caattcctta acgttgatgt cattttcaat agtattttga gccaaactta   5400

attttgcgag tgtgttttgt tttcttaact ttattattaa aaatgtataa aagtgaggcc   5460

aggcgtggtg gctcacgcct gtaatcccag cagtttggga ggctgaggca ggcggatcag   5520

ttgaggttgg gagttggaga ccagcccgtc caacatggtg aaagcctgtc tctactaaaa   5580

atacaaaaat cagctgggtg tggtggcgcg tgcctgtaat cccagctact caggaggctg   5640

aggcaggaga gttgcttgaa tcctagaggt ggaggttgca gtgagctgag atcgtgccat   5700

tgcactccag cctgggcaac aagagcaaaa ctctgtccca ataaataaat aaataaaatg   5760

ttctcttttg ttcctgttct tgtgcggtag tgtggtatag agttttatgg taattactgt   5820

gaattagtga ttctgaggga catatcagaa ctctgaggtt tgtttccttc tcatcttgag   5880

ggaaacagca aatgtatgtt aaaatgcttt tccaagggaa caacacatcc ttacattatt   5940

taaaccaatc tgcttcattt tcagagctgg ttgatcagag tgagtcagaa ggccccgtga   6000

tacaagaatc agctgaacca agccagttgg aagttccagc cacagaagaa ataaaagaga   6060

ctgatggaag ctctcagatc aagcaagaac cagaccccac gtggtagacc tcttccctcc   6120

tagggtaaat cagcttctgt gtcagggatg ctgtgtggtg tccatctgaa ccccctgcat   6180

acgcgtagct aatgtgatct ccccactttc acataagatg gtggccctgc cttcagggaa   6240

tgtgggagcc aggtgggagc cttcccggat atttaagcta gaagattcta cagggagatt   6300

ctccttggat caatatatgt ctctcagtca aagatgtaaa agcacttttg ccttaaaaag   6360

aatgttctgt ttctaaatag agtcaacgtt gtcctcctca ttggaattca ctatgagtca   6420

gaatcattag actgactttt ttttttccat agtaatagta ttttgcagag tctcacagag   6480

ctgcagatct tttgttcatc ttgcagagtt aacaagtctg atcctgttag tccagatttc   6540

ttaaatttgg ccaagttata ataggagcag tagcttgaga cccgaagtca ggaaactttg   6600

acaatggatt ttttttttta atccagagac ttgtactgga atttgcctta ccctgtcagc   6660

tcatggactt aaggtttcat cccgctttat gagtgcttct gaatccaagt cattgttacc   6720

tgaatttgca aattaagttg tgatattcgt gactgttaaa ttcctgtaat tagattaacc   6780

tctttgcttg cttgtttgtt ttctctccta ttttagctta aagtatcagt ggttgagaag   6840

agcttttcgg acctgttact accccaagct gtgtaatata cttgtataac agaaatacct   6900

tctatacaaa cctttttttc tacttttaga tagaaatgtc tactttttca gcagttctgt   6960

gaattaaaga gcagagtgac tgtgggtctg gaatggctgg tgtacttggg aatgtactat   7020

caggatttta cagcaatgct gggaaatgac agggaaaatg acaggaatga atctcaccag   7080

attttttatg tactcagcag agccttgagt tacggtgttt attttccaat caagtgaaga   7140

tatctcctac ttctcctact ggaacatctc agcttctgca gtgaagaaaa attcctgtga   7200

tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat catttaaatg atcctttgtt   7260

cacggctctc cttaatgact gagtgaacag ttcctatctg tatatttgac taaacctttt   7320

cctaagctat ctctcatggt tcctatgttt ttttatcata attaaaagca aaaccatctg   7380

gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa ttatagagga aatacagaga   7440

gaacctcttc cacttttact tttcgtccaa ataaaatgca tggtgtacca gaagttgaag   7500

atcgggttga ggattggggc tagctcgatg acactaaggc cccaacatcg cgggacctgc   7560

tgtggcgcgg attcttagga acgctgttct agccggcccc ctctccaggg gtcgccgtgg   7620

ccggcattat ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg   7680

ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc ttcctaggag agtcttacat   7740

gtgttgagat ttcacaagca atgcgagttg taaaatacca gctctacaag aagctaggct   7800

ctgtgacggc atagttttca gtagctttat cacaatattc acaatggaga attatatgac   7860

atggtagcag aaataggccc ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat   7920

agggtaatca ataaaatcca tccatgcctt tcacacacta agt                     7963


<210>  4169
<211>  918
<212>  PRT
<213>  Homo sapiens

<400>  4169

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala 
545                 550                 555                 560


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
                565                 570                 575


Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile 
            580                 585                 590


Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile 
        595                 600                 605


Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu 
    610                 615                 620


Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys 
625                 630                 635                 640


Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys 
                645                 650                 655


Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro 
            660                 665                 670


Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val 
        675                 680                 685


Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala 
    690                 695                 700


Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys 
705                 710                 715                 720


Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala 
                725                 730                 735


Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu 
            740                 745                 750


Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu 
        755                 760                 765


Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro 
    770                 775                 780


Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro 
785                 790                 795                 800


Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly 
                805                 810                 815


Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn 
            820                 825                 830


Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val 
        835                 840                 845


Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe 
    850                 855                 860


Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val 
865                 870                 875                 880


Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr 
                885                 890                 895


Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile 
            900                 905                 910


Lys Phe Thr Val Ile Arg 
        915


<210>  4170
<211>  5085
<212>  DNA
<213>  Homo sapiens

<400>  4170
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gtcaaagaag attggaatgt   1980

cagaattacc aagctacgga agcaagtgga agagattttt aatttgaaat ttgctcaagc   2040

tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt   2100

cttgtatgtg gaaggcttgc cagaggggat tcccttccga agccctacct ggtttggaat   2160

tccacgactt gaaaggatcg tccgcgggag taataaaatc aagttcgttg ttaaaaaacc   2220

tgaactagtt atttcctact tgcctcctgg gatggctagt aaaataaaca ctaaagcttt   2280

gcagtccccc aaaagaccac gaagtcctgg gagtaattca aaggttcctg aaattgaggt   2340

caccgtggaa ggccctaata acaacaatcc tcaaacctca gctgttcgaa ccccgaccca   2400

gactaacggt tctaacgttc ccttcaagcc acgagggaga gagttttcct ttgaggcctg   2460

gaatgccaaa atcacggacc taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg   2520

ggaagctctt ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg agtctttccc   2580

ggaagacttt tatgtggaag gcttacctga gggtgtgcca ttccgaagac catcgacttt   2640

tggcattccg aggctggaga agatactcag aaacaaagcc aaaattaagt tcatcattaa   2700

aaagcccgaa atgtttgaga cggcgattaa ggagagcacc tcctctaaga gccctcccag   2760

aaaaataaat tcatcaccca atgttaatac tactgcatca ggtgttgaag accttaacat   2820

cattcaggtg acaattccag atgatgataa tgaaagactc tcgaaagttg aaaaagctag   2880

acagctaaga gaacaagtga atgacctctt tagtcggaaa tttggtgaag ctattggtat   2940

gggttttcct gtgaaagttc cctacaggaa aatcacaatt aaccctggct gtgtggtggt   3000

tgatggcatg cccccggggg tgtccttcaa agcccccagc tacctggaaa tcagctccat   3060

gagaaggatc ttagactctg ccgagtttat caaattcacg gtcattagac catttccagg   3120

acttgtgatt aataaccagc tggttgatca gagtgagtca gaaggccccg tgatacaaga   3180

atcagctgaa ccaagccagt tggaagttcc agccacagaa ggtaaaagga cctcttccct   3240

cctagggtaa atcagcttct gtgtcaggga tgctgtgtgg tgtccatctg aaccccctgc   3300

atacgcgtag ctaatgtgat ctccccactt tcacataaga tggtggccct gccttcaggg   3360

aatgtgggag ccaggtggga gccttcccgg atatttaagc tagaagattc tacagggaga   3420

ttctccttgg atcaatatat gtctctcagt caaagatgta aaagcacttt tgccttaaaa   3480

agaatgttct gtttctaaat agagtcaacg ttgtcctcct cattggaatt cactatgagt   3540

cagaatcatt agactgactt ttttttttcc atagtaatag tattttgcag agtctcacag   3600

agctgcagat cttttgttca tcttgcagag ttaacaagtc tgatcctgtt agtccagatt   3660

tcttaaattt ggccaagtta taataggagc agtagcttga gacccgaagt caggaaactt   3720

tgacaatgga tttttttttt taatccagag acttgtactg gaatttgcct taccctgtca   3780

gctcatggac ttaaggtttc atcccgcttt atgagtgctt ctgaatccaa gtcattgtta   3840

cctgaatttg caaattaagt tgtgatattc gtgactgtta aattcctgta attagattaa   3900

cctctttgct tgcttgtttg ttttctctcc tattttagct taaagtatca gtggttgaga   3960

agagcttttc ggacctgtta ctaccccaag ctgtgtaata tacttgtata acagaaatac   4020

cttctataca aacctttttt tctactttta gatagaaatg tctacttttt cagcagttct   4080

gtgaattaaa gagcagagtg actgtgggtc tggaatggct ggtgtacttg ggaatgtact   4140

atcaggattt tacagcaatg ctgggaaatg acagggaaaa tgacaggaat gaatctcacc   4200

agatttttta tgtactcagc agagccttga gttacggtgt ttattttcca atcaagtgaa   4260

gatatctcct acttctccta ctggaacatc tcagcttctg cagtgaagaa aaattcctgt   4320

gatagttcag ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa tgatcctttg   4380

ttcacggctc tccttaatga ctgagtgaac agttcctatc tgtatatttg actaaacctt   4440

ttcctaagct atctctcatg gttcctatgt ttttttatca taattaaaag caaaaccatc   4500

tggatcacct aacagtcaga ggtcagtatc tcagcgtgtg aattatagag gaaatacaga   4560

gagaacctct tccactttta cttttcgtcc aaataaaatg catggtgtac cagaagttga   4620

agatcgggtt gaggattggg gctagctcga tgacactaag gccccaacat cgcgggacct   4680

gctgtggcgc ggattcttag gaacgctgtt ctagccggcc ccctctccag gggtcgccgt   4740

ggccggcatt atttcctagt tcttcttgta accctgaggt gccagcgcgg ggagtgagga   4800

ggggtcaggg ggctaaggat gcaacctctg acgttctgcg ccttcctagg agagtcttac   4860

atgtgttgag atttcacaag caatgcgagt tgtaaaatac cagctctaca agaagctagg   4920

ctctgtgacg gcatagtttt cagtagcttt atcacaatat tcacaatgga gaattatatg   4980

acatggtagc agaaataggc ccttttatgt gttgcttcta ttttacctca aattgtagat   5040

atagggtaat caataaaatc catccatgcc tttcacacac taagt                   5085


<210>  4171
<211>  942
<212>  PRT
<213>  Homo sapiens

<400>  4171

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr 
                565                 570                 575


Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys 
            580                 585                 590


Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro 
        595                 600                 605


Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys 
    610                 615                 620


Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val 
625                 630                 635                 640


Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg 
                645                 650                 655


Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly 
            660                 665                 670


Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys 
        675                 680                 685


Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly 
    690                 695                 700


Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro 
705                 710                 715                 720


Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg 
                725                 730                 735


Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys 
            740                 745                 750


Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala 
        755                 760                 765


Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser 
    770                 775                 780


Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile 
785                 790                 795                 800


Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val 
                805                 810                 815


Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg 
            820                 825                 830


Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr 
        835                 840                 845


Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro 
    850                 855                 860


Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met 
865                 870                 875                 880


Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
                885                 890                 895


Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu 
            900                 905                 910


Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu 
        915                 920                 925


Val Pro Ala Thr Glu Gly Lys Arg Thr Ser Ser Leu Leu Gly 
    930                 935                 940


<210>  4172
<211>  4108
<212>  DNA
<213>  Homo sapiens

<400>  4172
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   1980

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2040

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2100

atcaaacccg gagttcttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2160

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2220

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2280

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2340

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2400

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2460

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2520

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2580

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2640

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2700

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2760

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2820

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2880

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   2940

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3000

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca   3060

tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg   3120

atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag   3180

actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc   3240

ctaggagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct cctacttctc   3300

ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta   3360

gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg ctctccttaa   3420

tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa gctatctctc   3480

atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca cctaacagtc   3540

agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc tcttccactt   3600

ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg gttgaggatt   3660

ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg cgcggattct   3720

taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc attatttcct   3780

agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca gggggctaag   3840

gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt gagatttcac   3900

aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg acggcatagt   3960

tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt agcagaaata   4020

ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt aatcaataaa   4080

atccatccat gcctttcaca cactaagt                                      4108


<210>  4173
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  4173

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
                565                 570                 575


Ser Ser Leu Leu Lys Asn Leu Asn 
            580


<210>  4174
<211>  5202
<212>  DNA
<213>  Homo sapiens

<400>  4174
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagc   2100

tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc   2160

ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc ctacctggtt   2220

tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa   2280

aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa taaacactaa   2340

agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg ttcctgaaat   2400

tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg ttcgaacccc   2460

gacccagact aacggttcta acgttccctt caagccacga gggagagagt tttcctttga   2520

ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct tcaatgagaa   2580

atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc   2640

tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc gaagaccatc   2700

gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa ttaagttcat   2760

cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct ctaagagccc   2820

tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg ttgaagacct   2880

taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga aagttgaaaa   2940

agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg gtgaagctat   3000

tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc ctggctgtgt   3060

ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc tggaaatcag   3120

ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca ttagaccatt   3180

tccaggactt gtgattaata accagctggt tgatcagagt gagtcagaag gccccgtgat   3240

acaagaatca gctgaaccaa gccagttgga agttccagcc acagaagaaa taaaagagac   3300

tgatggaagc tctcagatca agcaagaacc agaccccacg tggtagacct cttccctcct   3360

agggtaaatc agcttctgtg tcagggatgc tgtgtggtgt ccatctgaac cccctgcata   3420

cgcgtagcta atgtgatctc cccactttca cataagatgg tggccctgcc ttcagggaat   3480

gtgggagcca ggtgggagcc ttcccggata tttaagctag aagattctac agggagattc   3540

tccttggatc aatatatgtc tctcagtcaa agatgtaaaa gcacttttgc cttaaaaaga   3600

atgttctgtt tctaaataga gtcaacgttg tcctcctcat tggaattcac tatgagtcag   3660

aatcattaga ctgacttttt tttttccata gtaatagtat tttgcagagt ctcacagagc   3720

tgcagatctt ttgttcatct tgcagagtta acaagtctga tcctgttagt ccagatttct   3780

taaatttggc caagttataa taggagcagt agcttgagac ccgaagtcag gaaactttga   3840

caatggattt ttttttttaa tccagagact tgtactggaa tttgccttac cctgtcagct   3900

catggactta aggtttcatc ccgctttatg agtgcttctg aatccaagtc attgttacct   3960

gaatttgcaa attaagttgt gatattcgtg actgttaaat tcctgtaatt agattaacct   4020

ctttgcttgc ttgtttgttt tctctcctat tttagcttaa agtatcagtg gttgagaaga   4080

gcttttcgga cctgttacta ccccaagctg tgtaatatac ttgtataaca gaaatacctt   4140

ctatacaaac ctttttttct acttttagat agaaatgtct actttttcag cagttctgtg   4200

aattaaagag cagagtgact gtgggtctgg aatggctggt gtacttggga atgtactatc   4260

aggattttac agcaatgctg ggaaatgaca gggaaaatga caggaatgaa tctcaccaga   4320

ttttttatgt actcagcaga gccttgagtt acggtgttta ttttccaatc aagtgaagat   4380

atctcctact tctcctactg gaacatctca gcttctgcag tgaagaaaaa ttcctgtgat   4440

agttcagttc tttagttttt ctatttgaaa aaaaaaaatc atttaaatga tcctttgttc   4500

acggctctcc ttaatgactg agtgaacagt tcctatctgt atatttgact aaaccttttc   4560

ctaagctatc tctcatggtt cctatgtttt tttatcataa ttaaaagcaa aaccatctgg   4620

atcacctaac agtcagaggt cagtatctca gcgtgtgaat tatagaggaa atacagagag   4680

aacctcttcc acttttactt ttcgtccaaa taaaatgcat ggtgtaccag aagttgaaga   4740

tcgggttgag gattggggct agctcgatga cactaaggcc ccaacatcgc gggacctgct   4800

gtggcgcgga ttcttaggaa cgctgttcta gccggccccc tctccagggg tcgccgtggc   4860

cggcattatt tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga gtgaggaggg   4920

gtcagggggc taaggatgca acctctgacg ttctgcgcct tcctaggaga gtcttacatg   4980

tgttgagatt tcacaagcaa tgcgagttgt aaaataccag ctctacaaga agctaggctc   5040

tgtgacggca tagttttcag tagctttatc acaatattca caatggagaa ttatatgaca   5100

tggtagcaga aataggccct tttatgtgtt gcttctattt tacctcaaat tgtagatata   5160

gggtaatcaa taaaatccat ccatgccttt cacacactaa gt                      5202


<210>  4175
<211>  974
<212>  PRT
<213>  Homo sapiens

<400>  4175

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala 
545                 550                 555                 560


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
                565                 570                 575


Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile 
            580                 585                 590


Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile 
        595                 600                 605


Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu 
    610                 615                 620


Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys 
625                 630                 635                 640


Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys 
                645                 650                 655


Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro 
            660                 665                 670


Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val 
        675                 680                 685


Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala 
    690                 695                 700


Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys 
705                 710                 715                 720


Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala 
                725                 730                 735


Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu 
            740                 745                 750


Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu 
        755                 760                 765


Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro 
    770                 775                 780


Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro 
785                 790                 795                 800


Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly 
                805                 810                 815


Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn 
            820                 825                 830


Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val 
        835                 840                 845


Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe 
    850                 855                 860


Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val 
865                 870                 875                 880


Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr 
                885                 890                 895


Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile 
            900                 905                 910


Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln 
        915                 920                 925


Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala 
    930                 935                 940


Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr 
945                 950                 955                 960


Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
                965                 970


<210>  4176
<211>  7153
<212>  DNA
<213>  Homo sapiens

<400>  4176
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   1980

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2040

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2100

atcaaacccg gagttcttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2160

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2220

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2280

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2340

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2400

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2460

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2520

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2580

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2640

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2700

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2760

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2820

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2880

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   2940

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3000

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattaggtaa   3060

gtgagagttt cctgcttagt cacaggagcg aatctggagc tcatgaggct gactcttcta   3120

aaatgcagcc acaggtagtc atcgaatccg gcttcctatg ctgtgcaatc aacaaatcaa   3180

aataacttgt gtcatcatta gaatgtcaga tgtgcttcta cgaactaagc tgactctttt   3240

aattctttgg caaagggttg gcaaactagg actgtttgcc aaattcaggc tgcctcctat   3300

ttttagagtc ttcctgaaac acagctacac ccgtattatc catggctgct ttcctgtcac   3360

agtgagtaag tagctgggac tgagaaggca tggcctccaa agtctaaaat atttactctc   3420

tagcactttg tagaaaaacc ttagctaggc acagtggcta acgcctgtaa tcccagcatt   3480

ttgggaggcc aaggcaggca gatcacctga ggtcaggagt tccagaccag cctggccaac   3540

atggtgaaat cccatctcta caaaaataaa acagttagct gggcatgatg gcgggtgcct   3600

gtaatcccag ctactcggga ggctgaggca ggatagtcgc ttgaacccag gaggtggagg   3660

ttgcaatgag ccaagatcat gccactgcac tccagcctgg acgacagagt gagactccat   3720

cacaagaaaa aaagaacttt gtcaacctct gtcttagggc gccttgtcac aggcttcggg   3780

tcagacggat tcaaccttgc atcagccatt tgttagccag gtcactctgt tctttgtctg   3840

taaatgagat tgatcgttgt tcccactgag agtgtcagct ccttcccgta gagcaggcat   3900

gatgattgta ctcacctctg acaccattgt gagtgccaca ttccttccca cgtccttgtc   3960

actgtaagag atgcccacct gagcaccaac cccaggttat cttccccttt gtcttccagc   4020

cccccagaaa cagctacgac tcaacctacc caatcatttc atcatcagat tgccactgtc   4080

tctagttcag gtctcttggg actggcactc agaaatctca taataaatcc tcttgaggct   4140

tctcatacac tcgtcttctt ccaatcttct ttccctcaaa atctcatatt ttggttccac   4200

ttcacccacc gtcattctcc atatcactcc caggagttag gcaaaaagcc ccttccgttc   4260

ttccgtatgt taaacttaga atcactctgt tccctgctct gcgtttctat tttttgtttt   4320

tcctccattt actagtagct taacactttc taacagtgtt cttattattg atacgtatct   4380

atctcttcca taagcttata aggtcacgga taatacttct cattgtagta cgtaaatgac   4440

gtgggctaga tatgagttga ataaacagtt atacctgtaa attcttacag agtgaaaata   4500

aattgttata ctttacaatt tgtttctctc tttagaccat ttccaggact tgtgattaat   4560

aaccgtgagt attttgtgaa gtgttttgtt tttgtttttt cctggggtct gacgtgtgtg   4620

cgtgtgagtg tgtatacatg cttaacgtat atcacgttac ttcacctatg tcagtaacca   4680

ggccaaatac ttgttttagc cctcagtaaa aacaccaggc acttcctagt tgtaaaatta   4740

ttcaagcttc ttaacttcct atcctcgatg cacttaatca taaaatggta ataatagcac   4800

cgattttggg ggagtcgttc cagtagatgg aaagcatctg gaacaggtgt cagcaagctc   4860

ctgccgacgt gtatgcataa agttttattg aaaccaccat cgtgtccatt tgtttatggc   4920

agaactgaga gatggcagca gcaagtgtgt gcctgcaaaa cctaaaatat ttactaattg   4980

gctctgcaag aaaagagttt gcatccccct aacctagaac agtgtctagc ctctagtatg   5040

tgtttagcct acagtatgtg ctcagcgaat acaatctata tttattactg cttttatgac   5100

tgttataatt actgtgcttg gatttcgtta caaagtaagt cacaatgtgc ctgcttctgt   5160

tagtatttca gcacagtgcc tggcacacat ggggctctca aatattgctg agcgagtgaa   5220

caaatgtcct ttcaattcct taacgttgat gtcattttca atagtatttt gagccaaact   5280

taattttgcg agtgtgtttt gttttcttaa ctttattatt aaaaatgtat aaaagtgagg   5340

ccaggcgtgg tggctcacgc ctgtaatccc agcagtttgg gaggctgagg caggcggatc   5400

agttgaggtt gggagttgga gaccagcccg tccaacatgg tgaaagcctg tctctactaa   5460

aaatacaaaa atcagctggg tgtggtggcg cgtgcctgta atcccagcta ctcaggaggc   5520

tgaggcagga gagttgcttg aatcctagag gtggaggttg cagtgagctg agatcgtgcc   5580

attgcactcc agcctgggca acaagagcaa aactctgtcc caataaataa ataaataaaa   5640

tgttctcttt tgttcctgtt cttgtgcggt agtgtggtat agagttttat ggtaattact   5700

gtgaattagt gattctgagg gacatatcag aactctgagg tttgtttcct tctcatcttg   5760

agggaaacag caaatgtatg ttaaaatgct tttccaaggg aacaacacat ccttacatta   5820

tttaaaccaa tctgcttcat tttcagagct ggttgatcag agtgagtcag aaggccccgt   5880

gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag aaataaaaga   5940

gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga cctcttccct   6000

cctaggctta aagtatcagt ggttgagaag agcttttcgg acctgttact accccaagct   6060

gtgtaatata cttgtataac agaaatacct tctatacaaa cctttttttc tacttttaga   6120

tagaaatgtc tactttttca gcagttctgt gaattaaaga gcagagtgac tgtgggtctg   6180

gaatggctgg tgtacttggg aatgtactat caggatttta cagcaatgct gggaaatgac   6240

agggaaaatg acaggaatga atctcaccag attttttatg tactcagcag agccttgagt   6300

tacggtgttt attttccaat caagtgaaga tatctcctac ttctcctact ggaacatctc   6360

agcttctgca gtgaagaaaa attcctgtga tagttcagtt ctttagtttt tctatttgaa   6420

aaaaaaaaat catttaaatg atcctttgtt cacggctctc cttaatgact gagtgaacag   6480

ttcctatctg tatatttgac taaacctttt cctaagctat ctctcatggt tcctatgttt   6540

ttttatcata attaaaagca aaaccatctg gatcacctaa cagtcagagg tcagtatctc   6600

agcgtgtgaa ttatagagga aatacagaga gaacctcttc cacttttact tttcgtccaa   6660

ataaaatgca tggtgtacca gaagttgaag atcgggttga ggattggggc tagctcgatg   6720

acactaaggc cccaacatcg cgggacctgc tgtggcgcgg attcttagga acgctgttct   6780

agccggcccc ctctccaggg gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac   6840

cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc aacctctgac   6900

gttctgcgcc ttcctaggag agtcttacat gtgttgagat ttcacaagca atgcgagttg   6960

taaaatacca gctctacaag aagctaggct ctgtgacggc atagttttca gtagctttat   7020

cacaatattc acaatggaga attatatgac atggtagcag aaataggccc ttttatgtgt   7080

tgcttctatt ttacctcaaa ttgtagatat agggtaatca ataaaatcca tccatgcctt   7140

tcacacacta agt                                                      7153


<210>  4177
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  4177

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
                565                 570                 575


Ser Ser Leu Leu Lys Asn Leu Asn 
            580


<210>  4178
<211>  4447
<212>  DNA
<213>  Homo sapiens

<400>  4178
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagctca   2040

agctcttgga ctcaccgagg cagtaaaagt accatatcct gtgtttgaat caaacccgga   2100

gttcttgtat gtggaaggct tgccagaggg gattcccttc cgaagcccta cctggtttgg   2160

aattccacga cttgaaagga tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa   2220

acctgaacta gttatttcct acttgcctcc tgggatggct agtaaaataa acactaaagc   2280

tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga   2340

ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc tcagctgttc gaaccccgac   2400

ccagactaac ggttctaacg ttcccttcaa gccacgaggg agagagtttt cctttgaggc   2460

ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa aatctcttca atgagaaatg   2520

tggggaagct cttggcctta aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt   2580

cccggaagac ttttatgtgg aaggcttacc tgagggtgtg ccattccgaa gaccatcgac   2640

ttttggcatt ccgaggctgg agaagatact cagaaacaaa gccaaaatta agttcatcat   2700

taaaaagccc gaaatgtttg agacggcgat taaggagagc acctcctcta agagccctcc   2760

cagaaaaata aattcatcac ccaatgttaa tactactgca tcaggtgttg aagaccttaa   2820

catcattcag gtgacaattc cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc   2880

tagacagcta agagaacaag tgaatgacct ctttagtcgg aaatttggtg aagctattgg   2940

tatgggtttt cctgtgaaag ttccctacag gaaaatcaca attaaccctg gctgtgtggt   3000

ggttgatggc atgcccccgg gggtgtcctt caaagccccc agctacctgg aaatcagctc   3060

catgagaagg atcttagact ctgccgagtt tatcaaattc acggtcatta gaccatttcc   3120

aggacttgtg attaataacc agctggttga tcagagtgag tcagaaggcc ccgtgataca   3180

agaatcagct gaaccaagcc agttggaagt tccagccaca gaagaaataa aagagactga   3240

tggaagctct cagatcaagc aagaaccaga ccccacgtgg tagacctctt ccctcctagg   3300

cttaaagtat cagtggttga gaagagcttt tcggacctgt tactacccca agctgtgtaa   3360

tatacttgta taacagaaat accttctata caaacctttt tttctacttt tagatagaaa   3420

tgtctacttt ttcagcagtt ctgtgaatta aagagcagag tgactgtggg tctggaatgg   3480

ctggtgtact tgggaatgta ctatcaggat tttacagcaa tgctgggaaa tgacagggaa   3540

aatgacagga atgaatctca ccagattttt tatgtactca gcagagcctt gagttacggt   3600

gtttattttc caatcaagtg aagatatctc ctacttctcc tactggaaca tctcagcttc   3660

tgcagtgaag aaaaattcct gtgatagttc agttctttag tttttctatt tgaaaaaaaa   3720

aaatcattta aatgatcctt tgttcacggc tctccttaat gactgagtga acagttccta   3780

tctgtatatt tgactaaacc ttttcctaag ctatctctca tggttcctat gtttttttat   3840

cataattaaa agcaaaacca tctggatcac ctaacagtca gaggtcagta tctcagcgtg   3900

tgaattatag aggaaataca gagagaacct cttccacttt tacttttcgt ccaaataaaa   3960

tgcatggtgt accagaagtt gaagatcggg ttgaggattg gggctagctc gatgacacta   4020

aggccccaac atcgcgggac ctgctgtggc gcggattctt aggaacgctg ttctagccgg   4080

ccccctctcc aggggtcgcc gtggccggca ttatttccta gttcttcttg taaccctgag   4140

gtgccagcgc ggggagtgag gaggggtcag ggggctaagg atgcaacctc tgacgttctg   4200

cgccttccta ggagagtctt acatgtgttg agatttcaca agcaatgcga gttgtaaaat   4260

accagctcta caagaagcta ggctctgtga cggcatagtt ttcagtagct ttatcacaat   4320

attcacaatg gagaattata tgacatggta gcagaaatag gcccttttat gtgttgcttc   4380

tattttacct caaattgtag atatagggta atcaataaaa tccatccatg cctttcacac   4440

actaagt                                                             4447


<210>  4179
<211>  953
<212>  PRT
<213>  Homo sapiens

<400>  4179

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu 
    530                 535                 540


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
545                 550                 555                 560


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
                565                 570                 575


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
            580                 585                 590


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
        595                 600                 605


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
    610                 615                 620


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
625                 630                 635                 640


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
                645                 650                 655


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
            660                 665                 670


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
        675                 680                 685


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
    690                 695                 700


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
705                 710                 715                 720


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
                725                 730                 735


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
            740                 745                 750


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
        755                 760                 765


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
    770                 775                 780


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
785                 790                 795                 800


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
                805                 810                 815


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
            820                 825                 830


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
        835                 840                 845


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
    850                 855                 860


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
865                 870                 875                 880


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
                885                 890                 895


Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser 
            900                 905                 910


Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu 
        915                 920                 925


Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln 
    930                 935                 940


Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  4180
<211>  7049
<212>  DNA
<213>  Homo sapiens

<400>  4180
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1980

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   2040

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2100

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2160

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2220

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2280

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2340

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2400

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2460

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2520

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2580

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2640

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2700

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2760

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2820

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2880

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   2940

cacggtcatt aggtaagtga gagtttcctg cttagtcaca ggagcgaatc tggagctcat   3000

gaggctgact cttctaaaat gcagccacag gtagtcatcg aatccggctt cctatgctgt   3060

gcaatcaaca aatcaaaata acttgtgtca tcattagaat gtcagatgtg cttctacgaa   3120

ctaagctgac tcttttaatt ctttggcaaa gggttggcaa actaggactg tttgccaaat   3180

tcaggctgcc tcctattttt agagtcttcc tgaaacacag ctacacccgt attatccatg   3240

gctgctttcc tgtcacagtg agtaagtagc tgggactgag aaggcatggc ctccaaagtc   3300

taaaatattt actctctagc actttgtaga aaaaccttag ctaggcacag tggctaacgc   3360

ctgtaatccc agcattttgg gaggccaagg caggcagatc acctgaggtc aggagttcca   3420

gaccagcctg gccaacatgg tgaaatccca tctctacaaa aataaaacag ttagctgggc   3480

atgatggcgg gtgcctgtaa tcccagctac tcgggaggct gaggcaggat agtcgcttga   3540

acccaggagg tggaggttgc aatgagccaa gatcatgcca ctgcactcca gcctggacga   3600

cagagtgaga ctccatcaca agaaaaaaag aactttgtca acctctgtct tagggcgcct   3660

tgtcacaggc ttcgggtcag acggattcaa ccttgcatca gccatttgtt agccaggtca   3720

ctctgttctt tgtctgtaaa tgagattgat cgttgttccc actgagagtg tcagctcctt   3780

cccgtagagc aggcatgatg attgtactca cctctgacac cattgtgagt gccacattcc   3840

ttcccacgtc cttgtcactg taagagatgc ccacctgagc accaacccca ggttatcttc   3900

ccctttgtct tccagccccc cagaaacagc tacgactcaa cctacccaat catttcatca   3960

tcagattgcc actgtctcta gttcaggtct cttgggactg gcactcagaa atctcataat   4020

aaatcctctt gaggcttctc atacactcgt cttcttccaa tcttctttcc ctcaaaatct   4080

catattttgg ttccacttca cccaccgtca ttctccatat cactcccagg agttaggcaa   4140

aaagcccctt ccgttcttcc gtatgttaaa cttagaatca ctctgttccc tgctctgcgt   4200

ttctattttt tgtttttcct ccatttacta gtagcttaac actttctaac agtgttctta   4260

ttattgatac gtatctatct cttccataag cttataaggt cacggataat acttctcatt   4320

gtagtacgta aatgacgtgg gctagatatg agttgaataa acagttatac ctgtaaattc   4380

ttacagagtg aaaataaatt gttatacttt acaatttgtt tctctcttta gaccatttcc   4440

aggacttgtg attaataacc gtgagtattt tgtgaagtgt tttgtttttg ttttttcctg   4500

gggtctgacg tgtgtgcgtg tgagtgtgta tacatgctta acgtatatca cgttacttca   4560

cctatgtcag taaccaggcc aaatacttgt tttagccctc agtaaaaaca ccaggcactt   4620

cctagttgta aaattattca agcttcttaa cttcctatcc tcgatgcact taatcataaa   4680

atggtaataa tagcaccgat tttgggggag tcgttccagt agatggaaag catctggaac   4740

aggtgtcagc aagctcctgc cgacgtgtat gcataaagtt ttattgaaac caccatcgtg   4800

tccatttgtt tatggcagaa ctgagagatg gcagcagcaa gtgtgtgcct gcaaaaccta   4860

aaatatttac taattggctc tgcaagaaaa gagtttgcat ccccctaacc tagaacagtg   4920

tctagcctct agtatgtgtt tagcctacag tatgtgctca gcgaatacaa tctatattta   4980

ttactgcttt tatgactgtt ataattactg tgcttggatt tcgttacaaa gtaagtcaca   5040

atgtgcctgc ttctgttagt atttcagcac agtgcctggc acacatgggg ctctcaaata   5100

ttgctgagcg agtgaacaaa tgtcctttca attccttaac gttgatgtca ttttcaatag   5160

tattttgagc caaacttaat tttgcgagtg tgttttgttt tcttaacttt attattaaaa   5220

atgtataaaa gtgaggccag gcgtggtggc tcacgcctgt aatcccagca gtttgggagg   5280

ctgaggcagg cggatcagtt gaggttggga gttggagacc agcccgtcca acatggtgaa   5340

agcctgtctc tactaaaaat acaaaaatca gctgggtgtg gtggcgcgtg cctgtaatcc   5400

cagctactca ggaggctgag gcaggagagt tgcttgaatc ctagaggtgg aggttgcagt   5460

gagctgagat cgtgccattg cactccagcc tgggcaacaa gagcaaaact ctgtcccaat   5520

aaataaataa ataaaatgtt ctcttttgtt cctgttcttg tgcggtagtg tggtatagag   5580

ttttatggta attactgtga attagtgatt ctgagggaca tatcagaact ctgaggtttg   5640

tttccttctc atcttgaggg aaacagcaaa tgtatgttaa aatgcttttc caagggaaca   5700

acacatcctt acattattta aaccaatctg cttcattttc agagctggtt gatcagagtg   5760

agtcagaagg ccccgtgata caagaatcag ctgaaccaag ccagttggaa gttccagcca   5820

cagaagaaat aaaagagact gatggaagct ctcagatcaa gcaagaacca gaccccacgt   5880

ggtagacctc ttccctccta ggcttaaagt atcagtggtt gagaagagct tttcggacct   5940

gttactaccc caagctgtgt aatatacttg tataacagaa ataccttcta tacaaacctt   6000

tttttctact tttagataga aatgtctact ttttcagcag ttctgtgaat taaagagcag   6060

agtgactgtg ggtctggaat ggctggtgta cttgggaatg tactatcagg attttacagc   6120

aatgctggga aatgacaggg aaaatgacag gaatgaatct caccagattt tttatgtact   6180

cagcagagcc ttgagttacg gtgtttattt tccaatcaag tgaagatatc tcctacttct   6240

cctactggaa catctcagct tctgcagtga agaaaaattc ctgtgatagt tcagttcttt   6300

agtttttcta tttgaaaaaa aaaaatcatt taaatgatcc tttgttcacg gctctcctta   6360

atgactgagt gaacagttcc tatctgtata tttgactaaa ccttttccta agctatctct   6420

catggttcct atgttttttt atcataatta aaagcaaaac catctggatc acctaacagt   6480

cagaggtcag tatctcagcg tgtgaattat agaggaaata cagagagaac ctcttccact   6540

tttacttttc gtccaaataa aatgcatggt gtaccagaag ttgaagatcg ggttgaggat   6600

tggggctagc tcgatgacac taaggcccca acatcgcggg acctgctgtg gcgcggattc   6660

ttaggaacgc tgttctagcc ggccccctct ccaggggtcg ccgtggccgg cattatttcc   6720

tagttcttct tgtaaccctg aggtgccagc gcggggagtg aggaggggtc agggggctaa   6780

ggatgcaacc tctgacgttc tgcgccttcc taggagagtc ttacatgtgt tgagatttca   6840

caagcaatgc gagttgtaaa ataccagctc tacaagaagc taggctctgt gacggcatag   6900

ttttcagtag ctttatcaca atattcacaa tggagaatta tatgacatgg tagcagaaat   6960

aggccctttt atgtgttgct tctattttac ctcaaattgt agatataggg taatcaataa   7020

aatccatcca tgcctttcac acactaagt                                     7049


<210>  4181
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  4181

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
            420                 425                 430


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
        435                 440                 445


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
    450                 455                 460


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser 
465                 470                 475                 480


Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
                485                 490                 495


<210>  4182
<211>  8009
<212>  DNA
<213>  Homo sapiens

<400>  4182
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gtcaaagaag attggaatgt   1980

cagaattacc aagctacgga agcaagtgga agagattttt aatttgaaat ttgcttagat   2040

ttgttgacag cggtttcctg gagtgctgtc ttgagaacga ttctgaggag gctcagcaag   2100

aaagagtgtt tcagttgatt gggtgtgtct gtcatggaga aggaactcaa gctcttggac   2160

tcaccgaggc agtaaaagta ccatatcctg tgtttgaatc aaacccggag ttcttgtatg   2220

tggaaggctt gccagagggg attcccttcc gaagccctac ctggtttgga attccacgac   2280

ttgaaaggat cgtccgcggg agtaataaaa tcaagttcgt tgttaaaaaa cctgaactag   2340

ttatttccta cttgcctcct gggatggcta gtaaaataaa cactaaagct ttgcagtccc   2400

ccaaaagacc acgaagtcct gggagtaatt caaaggttcc tgaaattgag gtcaccgtgg   2460

aaggccctaa taacaacaat cctcaaacct cagctgttcg aaccccgacc cagactaacg   2520

gttctaacgt tcccttcaag ccacgaggga gagagttttc ctttgaggcc tggaatgcca   2580

aaatcacgga cctaaaacag aaagttgaaa atctcttcaa tgagaaatgt ggggaagctc   2640

ttggccttaa acaagctgtg aaggtgccgt tcgcgttatt tgagtctttc ccggaagact   2700

tttatgtgga aggcttacct gagggtgtgc cattccgaag accatcgact tttggcattc   2760

cgaggctgga gaagatactc agaaacaaag ccaaaattaa gttcatcatt aaaaagcccg   2820

aaatgtttga gacggcgatt aaggagagca cctcctctaa gagccctccc agaaaaataa   2880

attcatcacc caatgttaat actactgcat caggtgttga agaccttaac atcattcagg   2940

tgacaattcc agatgatgat aatgaaagac tctcgaaagt tgaaaaagct agacagctaa   3000

gagaacaagt gaatgacctc tttagtcgga aatttggtga agctattggt atgggttttc   3060

ctgtgaaagt tccctacagg aaaatcacaa ttaaccctgg ctgtgtggtg gttgatggca   3120

tgcccccggg ggtgtccttc aaagccccca gctacctgga aatcagctcc atgagaagga   3180

tcttagactc tgccgagttt atcaaattca cggtcattag gtaagtgaga gtttcctgct   3240

tagtcacagg agcgaatctg gagctcatga ggctgactct tctaaaatgc agccacaggt   3300

agtcatcgaa tccggcttcc tatgctgtgc aatcaacaaa tcaaaataac ttgtgtcatc   3360

attagaatgt cagatgtgct tctacgaact aagctgactc ttttaattct ttggcaaagg   3420

gttggcaaac taggactgtt tgccaaattc aggctgcctc ctatttttag agtcttcctg   3480

aaacacagct acacccgtat tatccatggc tgctttcctg tcacagtgag taagtagctg   3540

ggactgagaa ggcatggcct ccaaagtcta aaatatttac tctctagcac tttgtagaaa   3600

aaccttagct aggcacagtg gctaacgcct gtaatcccag cattttggga ggccaaggca   3660

ggcagatcac ctgaggtcag gagttccaga ccagcctggc caacatggtg aaatcccatc   3720

tctacaaaaa taaaacagtt agctgggcat gatggcgggt gcctgtaatc ccagctactc   3780

gggaggctga ggcaggatag tcgcttgaac ccaggaggtg gaggttgcaa tgagccaaga   3840

tcatgccact gcactccagc ctggacgaca gagtgagact ccatcacaag aaaaaaagaa   3900

ctttgtcaac ctctgtctta gggcgccttg tcacaggctt cgggtcagac ggattcaacc   3960

ttgcatcagc catttgttag ccaggtcact ctgttctttg tctgtaaatg agattgatcg   4020

ttgttcccac tgagagtgtc agctccttcc cgtagagcag gcatgatgat tgtactcacc   4080

tctgacacca ttgtgagtgc cacattcctt cccacgtcct tgtcactgta agagatgccc   4140

acctgagcac caaccccagg ttatcttccc ctttgtcttc cagcccccca gaaacagcta   4200

cgactcaacc tacccaatca tttcatcatc agattgccac tgtctctagt tcaggtctct   4260

tgggactggc actcagaaat ctcataataa atcctcttga ggcttctcat acactcgtct   4320

tcttccaatc ttctttccct caaaatctca tattttggtt ccacttcacc caccgtcatt   4380

ctccatatca ctcccaggag ttaggcaaaa agccccttcc gttcttccgt atgttaaact   4440

tagaatcact ctgttccctg ctctgcgttt ctattttttg tttttcctcc atttactagt   4500

agcttaacac tttctaacag tgttcttatt attgatacgt atctatctct tccataagct   4560

tataaggtca cggataatac ttctcattgt agtacgtaaa tgacgtgggc tagatatgag   4620

ttgaataaac agttatacct gtaaattctt acagagtgaa aataaattgt tatactttac   4680

aatttgtttc tctctttaga ccatttccag gacttgtgat taataaccgt gagtattttg   4740

tgaagtgttt tgtttttgtt ttttcctggg gtctgacgtg tgtgcgtgtg agtgtgtata   4800

catgcttaac gtatatcacg ttacttcacc tatgtcagta accaggccaa atacttgttt   4860

tagccctcag taaaaacacc aggcacttcc tagttgtaaa attattcaag cttcttaact   4920

tcctatcctc gatgcactta atcataaaat ggtaataata gcaccgattt tgggggagtc   4980

gttccagtag atggaaagca tctggaacag gtgtcagcaa gctcctgccg acgtgtatgc   5040

ataaagtttt attgaaacca ccatcgtgtc catttgttta tggcagaact gagagatggc   5100

agcagcaagt gtgtgcctgc aaaacctaaa atatttacta attggctctg caagaaaaga   5160

gtttgcatcc ccctaaccta gaacagtgtc tagcctctag tatgtgttta gcctacagta   5220

tgtgctcagc gaatacaatc tatatttatt actgctttta tgactgttat aattactgtg   5280

cttggatttc gttacaaagt aagtcacaat gtgcctgctt ctgttagtat ttcagcacag   5340

tgcctggcac acatggggct ctcaaatatt gctgagcgag tgaacaaatg tcctttcaat   5400

tccttaacgt tgatgtcatt ttcaatagta ttttgagcca aacttaattt tgcgagtgtg   5460

ttttgttttc ttaactttat tattaaaaat gtataaaagt gaggccaggc gtggtggctc   5520

acgcctgtaa tcccagcagt ttgggaggct gaggcaggcg gatcagttga ggttgggagt   5580

tggagaccag cccgtccaac atggtgaaag cctgtctcta ctaaaaatac aaaaatcagc   5640

tgggtgtggt ggcgcgtgcc tgtaatccca gctactcagg aggctgaggc aggagagttg   5700

cttgaatcct agaggtggag gttgcagtga gctgagatcg tgccattgca ctccagcctg   5760

ggcaacaaga gcaaaactct gtcccaataa ataaataaat aaaatgttct cttttgttcc   5820

tgttcttgtg cggtagtgtg gtatagagtt ttatggtaat tactgtgaat tagtgattct   5880

gagggacata tcagaactct gaggtttgtt tccttctcat cttgagggaa acagcaaatg   5940

tatgttaaaa tgcttttcca agggaacaac acatccttac attatttaaa ccaatctgct   6000

tcattttcag agctggttga tcagagtgag tcagaaggcc ccgtgataca agaatcagct   6060

gaaccaagcc agttggaagt tccagccaca gaagaaataa aagagactga tggaagctct   6120

cagatcaagc aagaaccaga ccccacgtgg tagacctctt ccctcctagg gtaaatcagc   6180

ttctgtgtca gggatgctgt gtggtgtcca tctgaacccc ctgcatacgc gtagctaatg   6240

tgatctcccc actttcacat aagatggtgg ccctgccttc agggaatgtg ggagccaggt   6300

gggagccttc ccggatattt aagctagaag attctacagg gagattctcc ttggatcaat   6360

atatgtctct cagtcaaaga tgtaaaagca cttttgcctt aaaaagaatg ttctgtttct   6420

aaatagagtc aacgttgtcc tcctcattgg aattcactat gagtcagaat cattagactg   6480

actttttttt ttccatagta atagtatttt gcagagtctc acagagctgc agatcttttg   6540

ttcatcttgc agagttaaca agtctgatcc tgttagtcca gatttcttaa atttggccaa   6600

gttataatag gagcagtagc ttgagacccg aagtcaggaa actttgacaa tggatttttt   6660

tttttaatcc agagacttgt actggaattt gccttaccct gtcagctcat ggacttaagg   6720

tttcatcccg ctttatgagt gcttctgaat ccaagtcatt gttacctgaa tttgcaaatt   6780

aagttgtgat attcgtgact gttaaattcc tgtaattaga ttaacctctt tgcttgcttg   6840

tttgttttct ctcctatttt agcttaaagt atcagtggtt gagaagagct tttcggacct   6900

gttactaccc caagctgtgt aatatacttg tataacagaa ataccttcta tacaaacctt   6960

tttttctact tttagataga aatgtctact ttttcagcag ttctgtgaat taaagagcag   7020

agtgactgtg ggtctggaat ggctggtgta cttgggaatg tactatcagg attttacagc   7080

aatgctggga aatgacaggg aaaatgacag gaatgaatct caccagattt tttatgtact   7140

cagcagagcc ttgagttacg gtgtttattt tccaatcaag tgaagatatc tcctacttct   7200

cctactggaa catctcagct tctgcagtga agaaaaattc ctgtgatagt tcagttcttt   7260

agtttttcta tttgaaaaaa aaaaatcatt taaatgatcc tttgttcacg gctctcctta   7320

atgactgagt gaacagttcc tatctgtata tttgactaaa ccttttccta agctatctct   7380

catggttcct atgttttttt atcataatta aaagcaaaac catctggatc acctaacagt   7440

cagaggtcag tatctcagcg tgtgaattat agaggaaata cagagagaac ctcttccact   7500

tttacttttc gtccaaataa aatgcatggt gtaccagaag ttgaagatcg ggttgaggat   7560

tggggctagc tcgatgacac taaggcccca acatcgcggg acctgctgtg gcgcggattc   7620

ttaggaacgc tgttctagcc ggccccctct ccaggggtcg ccgtggccgg cattatttcc   7680

tagttcttct tgtaaccctg aggtgccagc gcggggagtg aggaggggtc agggggctaa   7740

ggatgcaacc tctgacgttc tgcgccttcc taggagagtc ttacatgtgt tgagatttca   7800

caagcaatgc gagttgtaaa ataccagctc tacaagaagc taggctctgt gacggcatag   7860

ttttcagtag ctttatcaca atattcacaa tggagaatta tatgacatgg tagcagaaat   7920

aggccctttt atgtgttgct tctattttac ctcaaattgt agatataggg taatcaataa   7980

aatccatcca tgcctttcac acactaagt                                     8009


<210>  4183
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  4183

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535


<210>  4184
<211>  3721
<212>  DNA
<213>  Homo sapiens

<400>  4184
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1860

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1920

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1980

aatcaaaccc ggagttcttg aaaggatcgt ccgcgggagt aataaaatca agttcgttgt   2040

taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta aaataaacac   2100

taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa aggttcctga   2160

aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag ctgttcgaac   2220

cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag agttttcctt   2280

tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc tcttcaatga   2340

gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg cgttatttga   2400

gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat tccgaagacc   2460

atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca aaattaagtt   2520

catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct cctctaagag   2580

ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag gtgttgaaga   2640

ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct cgaaagttga   2700

aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat ttggtgaagc   2760

tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta accctggctg   2820

tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct acctggaaat   2880

cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg tcattagacc   2940

atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag aaggccccgt   3000

gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag aaataaaaga   3060

gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga cctcttccct   3120

cctaggcaaa accatctgga tcacctaaca gtcagaggtc agtatctcag cgtgtgaatt   3180

atagaggaaa tacagagaga acctcttcca cttttacttt tcgtccaaat aaaatgcatg   3240

gtgtaccaga agttgaagat cgggttgagg attggggcta gctcgatgac actaaggccc   3300

caacatcgcg ggacctgctg tggcgcggat tcttaggaac gctgttctag ccggccccct   3360

ctccaggggt cgccgtggcc ggcattattt cctagttctt cttgtaaccc tgaggtgcca   3420

gcgcggggag tgaggagggg tcagggggct aaggatgcaa cctctgacgt tctgcgcctt   3480

cctaggagag tcttacatgt gttgagattt cacaagcaat gcgagttgta aaataccagc   3540

tctacaagaa gctaggctct gtgacggcat agttttcagt agctttatca caatattcac   3600

aatggagaat tatatgacat ggtagcagaa ataggccctt ttatgtgttg cttctatttt   3660

acctcaaatt gtagatatag ggtaatcaat aaaatccatc catgcctttc acacactaag   3720

t                                                                   3721


<210>  4185
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  4185

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg 
            420                 425                 430


Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe 
        435                 440                 445


Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val 
    450                 455                 460


Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile 
465                 470                 475                 480


Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
                485                 490


<210>  4186
<211>  7871
<212>  DNA
<213>  Homo sapiens

<400>  4186
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040

taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2100

ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2160

ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2220

ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2280

ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2340

atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2400

agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2460

agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2520

tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2580

ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2640

tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2700

ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2760

atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2820

ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2880

tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   2940

ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   3000

tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3060

ttatcaaatt cacggtcatt aggtaagtga gagtttcctg cttagtcaca ggagcgaatc   3120

tggagctcat gaggctgact cttctaaaat gcagccacag gtagtcatcg aatccggctt   3180

cctatgctgt gcaatcaaca aatcaaaata acttgtgtca tcattagaat gtcagatgtg   3240

cttctacgaa ctaagctgac tcttttaatt ctttggcaaa gggttggcaa actaggactg   3300

tttgccaaat tcaggctgcc tcctattttt agagtcttcc tgaaacacag ctacacccgt   3360

attatccatg gctgctttcc tgtcacagtg agtaagtagc tgggactgag aaggcatggc   3420

ctccaaagtc taaaatattt actctctagc actttgtaga aaaaccttag ctaggcacag   3480

tggctaacgc ctgtaatccc agcattttgg gaggccaagg caggcagatc acctgaggtc   3540

aggagttcca gaccagcctg gccaacatgg tgaaatccca tctctacaaa aataaaacag   3600

ttagctgggc atgatggcgg gtgcctgtaa tcccagctac tcgggaggct gaggcaggat   3660

agtcgcttga acccaggagg tggaggttgc aatgagccaa gatcatgcca ctgcactcca   3720

gcctggacga cagagtgaga ctccatcaca agaaaaaaag aactttgtca acctctgtct   3780

tagggcgcct tgtcacaggc ttcgggtcag acggattcaa ccttgcatca gccatttgtt   3840

agccaggtca ctctgttctt tgtctgtaaa tgagattgat cgttgttccc actgagagtg   3900

tcagctcctt cccgtagagc aggcatgatg attgtactca cctctgacac cattgtgagt   3960

gccacattcc ttcccacgtc cttgtcactg taagagatgc ccacctgagc accaacccca   4020

ggttatcttc ccctttgtct tccagccccc cagaaacagc tacgactcaa cctacccaat   4080

catttcatca tcagattgcc actgtctcta gttcaggtct cttgggactg gcactcagaa   4140

atctcataat aaatcctctt gaggcttctc atacactcgt cttcttccaa tcttctttcc   4200

ctcaaaatct catattttgg ttccacttca cccaccgtca ttctccatat cactcccagg   4260

agttaggcaa aaagcccctt ccgttcttcc gtatgttaaa cttagaatca ctctgttccc   4320

tgctctgcgt ttctattttt tgtttttcct ccatttacta gtagcttaac actttctaac   4380

agtgttctta ttattgatac gtatctatct cttccataag cttataaggt cacggataat   4440

acttctcatt gtagtacgta aatgacgtgg gctagatatg agttgaataa acagttatac   4500

ctgtaaattc ttacagagtg aaaataaatt gttatacttt acaatttgtt tctctcttta   4560

gaccatttcc aggacttgtg attaataacc gtgagtattt tgtgaagtgt tttgtttttg   4620

ttttttcctg gggtctgacg tgtgtgcgtg tgagtgtgta tacatgctta acgtatatca   4680

cgttacttca cctatgtcag taaccaggcc aaatacttgt tttagccctc agtaaaaaca   4740

ccaggcactt cctagttgta aaattattca agcttcttaa cttcctatcc tcgatgcact   4800

taatcataaa atggtaataa tagcaccgat tttgggggag tcgttccagt agatggaaag   4860

catctggaac aggtgtcagc aagctcctgc cgacgtgtat gcataaagtt ttattgaaac   4920

caccatcgtg tccatttgtt tatggcagaa ctgagagatg gcagcagcaa gtgtgtgcct   4980

gcaaaaccta aaatatttac taattggctc tgcaagaaaa gagtttgcat ccccctaacc   5040

tagaacagtg tctagcctct agtatgtgtt tagcctacag tatgtgctca gcgaatacaa   5100

tctatattta ttactgcttt tatgactgtt ataattactg tgcttggatt tcgttacaaa   5160

gtaagtcaca atgtgcctgc ttctgttagt atttcagcac agtgcctggc acacatgggg   5220

ctctcaaata ttgctgagcg agtgaacaaa tgtcctttca attccttaac gttgatgtca   5280

ttttcaatag tattttgagc caaacttaat tttgcgagtg tgttttgttt tcttaacttt   5340

attattaaaa atgtataaaa gtgaggccag gcgtggtggc tcacgcctgt aatcccagca   5400

gtttgggagg ctgaggcagg cggatcagtt gaggttggga gttggagacc agcccgtcca   5460

acatggtgaa agcctgtctc tactaaaaat acaaaaatca gctgggtgtg gtggcgcgtg   5520

cctgtaatcc cagctactca ggaggctgag gcaggagagt tgcttgaatc ctagaggtgg   5580

aggttgcagt gagctgagat cgtgccattg cactccagcc tgggcaacaa gagcaaaact   5640

ctgtcccaat aaataaataa ataaaatgtt ctcttttgtt cctgttcttg tgcggtagtg   5700

tggtatagag ttttatggta attactgtga attagtgatt ctgagggaca tatcagaact   5760

ctgaggtttg tttccttctc atcttgaggg aaacagcaaa tgtatgttaa aatgcttttc   5820

caagggaaca acacatcctt acattattta aaccaatctg cttcattttc agagctggtt   5880

gatcagagtg agtcagaagg ccccgtgata caagaatcag ctgaaccaag ccagttggaa   5940

gttccagcca cagaagaaat aaaagagact gatggaagct ctcagatcaa gcaagaacca   6000

gaccccacgt ggtagacctc ttccctccta gggtaaatca gcttctgtgt cagggatgct   6060

gtgtggtgtc catctgaacc ccctgcatac gcgtagctaa tgtgatctcc ccactttcac   6120

ataagatggt ggccctgcct tcagggaatg tgggagccag gtgggagcct tcccggatat   6180

ttaagctaga agattctaca gggagattct ccttggatca atatatgtct ctcagtcaaa   6240

gatgtaaaag cacttttgcc ttaaaaagaa tgttctgttt ctaaatagag tcaacgttgt   6300

cctcctcatt ggaattcact atgagtcaga atcattagac tgactttttt ttttccatag   6360

taatagtatt ttgcagagtc tcacagagct gcagatcttt tgttcatctt gcagagttaa   6420

caagtctgat cctgttagtc cagatttctt aaatttggcc aagttataat aggagcagta   6480

gcttgagacc cgaagtcagg aaactttgac aatggatttt tttttttaat ccagagactt   6540

gtactggaat ttgccttacc ctgtcagctc atggacttaa ggtttcatcc cgctttatga   6600

gtgcttctga atccaagtca ttgttacctg aatttgcaaa ttaagttgtg atattcgtga   6660

ctgttaaatt cctgtaatta gattaacctc tttgcttgct tgtttgtttt ctctcctatt   6720

ttagcttaaa gtatcagtgg ttgagaagag cttttcggac ctgttactac cccaagctgt   6780

gtaatatact tgtataacag aaataccttc tatacaaacc tttttttcta cttttagata   6840

gaaatgtcta ctttttcagc agttctgtga attaaagagc agagtgactg tgggtctgga   6900

atggctggtg tacttgggaa tgtactatca ggattttaca gcaatgctgg gaaatgacag   6960

ggaaaatgac aggaatgaat ctcaccagat tttttatgta ctcagcagag ccttgagtta   7020

cggtgtttat tttccaatca agtgaagata tctcctactt ctcctactgg aacatctcag   7080

cttctgcagt gaagaaaaat tcctgtgata gttcagttct ttagtttttc tatttgaaaa   7140

aaaaaaatca tttaaatgat cctttgttca cggctctcct taatgactga gtgaacagtt   7200

cctatctgta tatttgacta aaccttttcc taagctatct ctcatggttc ctatgttttt   7260

ttatcataat taaaagcaaa accatctgga tcacctaaca gtcagaggtc agtatctcag   7320

cgtgtgaatt atagaggaaa tacagagaga acctcttcca cttttacttt tcgtccaaat   7380

aaaatgcatg gtgtaccaga agttgaagat cgggttgagg attggggcta gctcgatgac   7440

actaaggccc caacatcgcg ggacctgctg tggcgcggat tcttaggaac gctgttctag   7500

ccggccccct ctccaggggt cgccgtggcc ggcattattt cctagttctt cttgtaaccc   7560

tgaggtgcca gcgcggggag tgaggagggg tcagggggct aaggatgcaa cctctgacgt   7620

tctgcgcctt cctaggagag tcttacatgt gttgagattt cacaagcaat gcgagttgta   7680

aaataccagc tctacaagaa gctaggctct gtgacggcat agttttcagt agctttatca   7740

caatattcac aatggagaat tatatgacat ggtagcagaa ataggccctt ttatgtgttg   7800

cttctatttt acctcaaatt gtagatatag ggtaatcaat aaaatccatc catgcctttc   7860

acacactaag t                                                        7871


<210>  4187
<211>  833
<212>  PRT
<213>  Homo sapiens

<400>  4187

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
    450                 455                 460


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
465                 470                 475                 480


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
                485                 490                 495


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
            500                 505                 510


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
        515                 520                 525


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
    530                 535                 540


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
545                 550                 555                 560


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
                565                 570                 575


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
            580                 585                 590


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
        595                 600                 605


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
    610                 615                 620


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
625                 630                 635                 640


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
                645                 650                 655


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
            660                 665                 670


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
        675                 680                 685


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
    690                 695                 700


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
705                 710                 715                 720


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
                725                 730                 735


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
            740                 745                 750


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
        755                 760                 765


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
    770                 775                 780


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
785                 790                 795                 800


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
                805                 810                 815


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
            820                 825                 830


Arg 



<210>  4188
<211>  4410
<212>  DNA
<213>  Homo sapiens

<400>  4188
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2100

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2160

tttgaaattt gcttagattt gttgacagcg gtttcctgga gtgctgtctt gagaacgatt   2220

ctgaggaggc tcagcaagaa agagtgtttc agttgattgg gtgtgtctgt catggagaag   2280

gaactcaagc tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa   2340

acccggagtt cttgtatgtg gaaggcttgc cagaggggat tcccttccga agccctacct   2400

ggtttggaat tccacgactt gaaaggatcg tccgcgggag taataaaatc aagttcgttg   2460

ttaaaaaacc tgaactagtt atttcctact tgcctcctgg gatggctagt aaaataaaca   2520

ctaaagcttt gcagtccccc aaaagaccac gaagtcctgg gagtaattca aaggttcctg   2580

aaattgaggt caccgtggaa ggccctaata acaacaatcc tcaaacctca gctgttcgaa   2640

ccccgaccca gactaacggt tctaacgttc ccttcaagcc acgagggaga gagttttcct   2700

ttgaggcctg gaatgccaaa atcacggacc taaaacagaa agttgaaaat ctcttcaatg   2760

agaaatgtgg ggaagctctt ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg   2820

agtctttccc ggaagacttt tatgtggaag gcttacctga gggtgtgcca ttccgaagac   2880

catcgacttt tggcattccg aggctggaga agatactcag aaacaaagcc aaaattaagt   2940

tcatcattaa aaagcccgaa atgtttgaga cggcgattaa ggagagcacc tcctctaaga   3000

gccctcccag aaaaataaat tcatcaccca atgttaatac tactgcatca ggtgttgaag   3060

accttaacat cattcaggtg acaattccag atgatgataa tgaaagactc tcgaaagttg   3120

aaaaagctag acagctaaga gaacaagtga atgacctctt tagtcggaaa tttggtgaag   3180

ctattggtat gggttttcct gtgaaagttc cctacaggaa aatcacaatt aaccctggct   3240

gtgtggtggt tgatggcatg cccccggggg tgtccttcaa agcccccagc tacctggaaa   3300

tcagctccat gagaaggatc ttagactctg ccgagtttat caaattcacg gtcattagac   3360

catttccagg acttgtgatt aataaccagc tggttgatca gagtgagtca gaaggccccg   3420

tgatacaaga atcagctgaa ccaagccagt tggaagttcc agccacagaa gaaataaaag   3480

agactgatgg aagctctcag atcaagcaag aaccagaccc cacgtggtag acctcttccc   3540

tcctaggagc cttgagttac ggtgtttatt ttccaatcaa gtgaagatat ctcctacttc   3600

tcctactgga acatctcagc ttctgcagtg aagaaaaatt cctgtgatag ttcagttctt   3660

tagtttttct atttgaaaaa aaaaaatcat ttaaatgatc ctttgttcac ggctctcctt   3720

aatgactgag tgaacagttc ctatctgtat atttgactaa accttttcct aagctatctc   3780

tcatggttcc tatgtttttt tatcataatt aaaagcaaaa ccatctggat cacctaacag   3840

tcagaggtca gtatctcagc gtgtgaatta tagaggaaat acagagagaa cctcttccac   3900

ttttactttt cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc gggttgagga   3960

ttggggctag ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt ggcgcggatt   4020

cttaggaacg ctgttctagc cggccccctc tccaggggtc gccgtggccg gcattatttc   4080

ctagttcttc ttgtaaccct gaggtgccag cgcggggagt gaggaggggt cagggggcta   4140

aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg ttgagatttc   4200

acaagcaatg cgagttgtaa aataccagct ctacaagaag ctaggctctg tgacggcata   4260

gttttcagta gctttatcac aatattcaca atggagaatt atatgacatg gtagcagaaa   4320

taggcccttt tatgtgttgc ttctatttta cctcaaattg tagatatagg gtaatcaata   4380

aaatccatcc atgcctttca cacactaagt                                    4410


<210>  4189
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  4189

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala 
            580


<210>  4190
<211>  3970
<212>  DNA
<213>  Homo sapiens

<400>  4190
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2040

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2100

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2160

tgaatcaaac ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag   2220

ccctacctgg tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa   2280

gttcgttgtt aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa   2340

aataaacact aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa   2400

ggttcctgaa attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc   2460

tgttcgaacc ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga   2520

gttttccttt gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct   2580

cttcaatgag aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc   2640

gttatttgag tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt   2700

ccgaagacca tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa   2760

aattaagttc atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc   2820

ctctaagagc cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg   2880

tgttgaagac cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc   2940

gaaagttgaa aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt   3000

tggtgaagct attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa   3060

ccctggctgt gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta   3120

cctggaaatc agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt   3180

cattagacca tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga   3240

aggccccgtg atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga   3300

aataaaagag actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac   3360

ctcttccctc ctaggcaaaa ccatctggat cacctaacag tcagaggtca gtatctcagc   3420

gtgtgaatta tagaggaaat acagagagaa cctcttccac ttttactttt cgtccaaata   3480

aaatgcatgg tgtaccagaa gttgaagatc gggttgagga ttggggctag ctcgatgaca   3540

ctaaggcccc aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg ctgttctagc   3600

cggccccctc tccaggggtc gccgtggccg gcattatttc ctagttcttc ttgtaaccct   3660

gaggtgccag cgcggggagt gaggaggggt cagggggcta aggatgcaac ctctgacgtt   3720

ctgcgccttc ctaggagagt cttacatgtg ttgagatttc acaagcaatg cgagttgtaa   3780

aataccagct ctacaagaag ctaggctctg tgacggcata gttttcagta gctttatcac   3840

aatattcaca atggagaatt atatgacatg gtagcagaaa taggcccttt tatgtgttgc   3900

ttctatttta cctcaaattg tagatatagg gtaatcaata aaatccatcc atgcctttca   3960

cacactaagt                                                          3970


<210>  4191
<211>  978
<212>  PRT
<213>  Homo sapiens

<400>  4191

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu 
            580                 585                 590


Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg 
        595                 600                 605


Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys 
    610                 615                 620


Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys 
625                 630                 635                 640


Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly 
                645                 650                 655


Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn 
            660                 665                 670


Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn 
        675                 680                 685


Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu 
    690                 695                 700


Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu 
705                 710                 715                 720


Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys 
                725                 730                 735


Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu 
            740                 745                 750


Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile 
        755                 760                 765


Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile 
    770                 775                 780


Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser 
785                 790                 795                 800


Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr 
                805                 810                 815


Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro 
            820                 825                 830


Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu 
        835                 840                 845


Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile 
    850                 855                 860


Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn 
865                 870                 875                 880


Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys 
                885                 890                 895


Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser 
            900                 905                 910


Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val 
        915                 920                 925


Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile 
    930                 935                 940


Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu 
945                 950                 955                 960


Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro 
                965                 970                 975


Thr Trp 



<210>  4192
<211>  4346
<212>  DNA
<213>  Homo sapiens

<400>  4192
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   1980

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   2040

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2100

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2160

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2220

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2280

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2340

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2400

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2460

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2520

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2580

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2640

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2700

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2760

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2820

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2880

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   2940

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   3000

cggtcattag accatttcca ggacttgtga ttaataacca gctggttgat cagagtgagt   3060

cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt ccagccacag   3120

aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac cccacgtggt   3180

agacctcttc cctcctaggc ttaaagtatc agtggttgag aagagctttt cggacctgtt   3240

actaccccaa gctgtgtaat atacttgtat aacagaaata ccttctatac aaaccttttt   3300

ttctactttt agatagaaat gtctactttt tcagcagttc tgtgaattaa agagcagagt   3360

gactgtgggt ctggaatggc tggtgtactt gggaatgtac tatcaggatt ttacagcaat   3420

gctgggaaat gacagggaaa atgacaggaa tgaatctcac cagatttttt atgtactcag   3480

cagagccttg agttacggtg tttattttcc aatcaagtga agatatctcc tacttctcct   3540

actggaacat ctcagcttct gcagtgaaga aaaattcctg tgatagttca gttctttagt   3600

ttttctattt gaaaaaaaaa aatcatttaa atgatccttt gttcacggct ctccttaatg   3660

actgagtgaa cagttcctat ctgtatattt gactaaacct tttcctaagc tatctctcat   3720

ggttcctatg tttttttatc ataattaaaa gcaaaaccat ctggatcacc taacagtcag   3780

aggtcagtat ctcagcgtgt gaattataga ggaaatacag agagaacctc ttccactttt   3840

acttttcgtc caaataaaat gcatggtgta ccagaagttg aagatcgggt tgaggattgg   3900

ggctagctcg atgacactaa ggccccaaca tcgcgggacc tgctgtggcg cggattctta   3960

ggaacgctgt tctagccggc cccctctcca ggggtcgccg tggccggcat tatttcctag   4020

ttcttcttgt aaccctgagg tgccagcgcg gggagtgagg aggggtcagg gggctaagga   4080

tgcaacctct gacgttctgc gccttcctag gagagtctta catgtgttga gatttcacaa   4140

gcaatgcgag ttgtaaaata ccagctctac aagaagctag gctctgtgac ggcatagttt   4200

tcagtagctt tatcacaata ttcacaatgg agaattatat gacatggtag cagaaatagg   4260

cccttttatg tgttgcttct attttacctc aaattgtaga tatagggtaa tcaataaaat   4320

ccatccatgc ctttcacaca ctaagt                                        4346


<210>  4193
<211>  865
<212>  PRT
<213>  Homo sapiens

<400>  4193

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
    450                 455                 460


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
465                 470                 475                 480


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
                485                 490                 495


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
            500                 505                 510


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
        515                 520                 525


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
    530                 535                 540


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
545                 550                 555                 560


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
                565                 570                 575


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
            580                 585                 590


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
        595                 600                 605


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
    610                 615                 620


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
625                 630                 635                 640


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
                645                 650                 655


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
            660                 665                 670


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
        675                 680                 685


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
    690                 695                 700


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
705                 710                 715                 720


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
                725                 730                 735


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
            740                 745                 750


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
        755                 760                 765


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
    770                 775                 780


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
785                 790                 795                 800


Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile 
                805                 810                 815


Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln 
            820                 825                 830


Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile 
        835                 840                 845


Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr 
    850                 855                 860


Trp 
865


<210>  4194
<211>  4019
<212>  DNA
<213>  Homo sapiens

<400>  4194
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   1980

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2040

gaaatttgct tagatttgtt gacagcggtt tcctggagtg ctgtcttgag aacgattctg   2100

aggaggctca gcaagaaaga gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa   2160

ctcaagctct tggactcacc gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc   2220

cggagttctt gtatgtggaa ggcttgccag aggggattcc cttccgaagc cctacctggt   2280

ttggaattcc acgacttgaa aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta   2340

aaaaacctga actagttatt tcctacttgc ctcctgggat ggctagtaaa ataaacacta   2400

aagctttgca gtcccccaaa agaccacgaa gtcctgggag taattcaaag gttcctgaaa   2460

ttgaggtcac cgtggaaggc cctaataaca acaatcctca aacctcagct gttcgaaccc   2520

cgacccagac taacggttct aacgttccct tcaagccacg agggagagag ttttcctttg   2580

aggcctggaa tgccaaaatc acggacctaa aacagaaagt tgaaaatctc ttcaatgaga   2640

aatgtgggga agctcttggc cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt   2700

ctttcccgga agacttttat gtggaaggct tacctgaggg tgtgccattc cgaagaccat   2760

cgacttttgg cattccgagg ctggagaaga tactcagaaa caaagccaaa attaagttca   2820

tcattaaaaa gcccgaaatg tttgagacgg cgattaagga gagcacctcc tctaagagcc   2880

ctcccagaaa aataaattca tcacccaatg ttaatactac tgcatcaggt gttgaagacc   2940

ttaacatcat tcaggtgaca attccagatg atgataatga aagactctcg aaagttgaaa   3000

aagctagaca gctaagagaa caagtgaatg acctctttag tcggaaattt ggtgaagcta   3060

ttggtatggg ttttcctgtg aaagttccct acaggaaaat cacaattaac cctggctgtg   3120

tggtggttga tggcatgccc ccgggggtgt ccttcaaagc ccccagctac ctggaaatca   3180

gctccatgag aaggatctta gactctgccg agtttatcaa attcacggtc attagaccat   3240

ttccaggact tgtgattaat aaccagctgg ttgatcagag tgagtcagaa ggccccgtga   3300

tacaagaatc agctgaacca agccagttgg aagttccagc cacagaagaa ataaaagaga   3360

ctgatggaag ctctcagatc aagcaagaac cagaccccac gtggtagacc tcttccctcc   3420

taggcaaaac catctggatc acctaacagt cagaggtcag tatctcagcg tgtgaattat   3480

agaggaaata cagagagaac ctcttccact tttacttttc gtccaaataa aatgcatggt   3540

gtaccagaag ttgaagatcg ggttgaggat tggggctagc tcgatgacac taaggcccca   3600

acatcgcggg acctgctgtg gcgcggattc ttaggaacgc tgttctagcc ggccccctct   3660

ccaggggtcg ccgtggccgg cattatttcc tagttcttct tgtaaccctg aggtgccagc   3720

gcggggagtg aggaggggtc agggggctaa ggatgcaacc tctgacgttc tgcgccttcc   3780

taggagagtc ttacatgtgt tgagatttca caagcaatgc gagttgtaaa ataccagctc   3840

tacaagaagc taggctctgt gacggcatag ttttcagtag ctttatcaca atattcacaa   3900

tggagaatta tatgacatgg tagcagaaat aggccctttt atgtgttgct tctattttac   3960

ctcaaattgt agatataggg taatcaataa aatccatcca tgcctttcac acactaagt    4019


<210>  4195
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  4195

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  4196
<211>  5013
<212>  DNA
<213>  Homo sapiens

<400>  4196
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gctcaagctc ttggactcac   1980

cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct tgtatgtgga   2040

aggcttgcca gaggggattc ccttccgaag ccctacctgg tttggaattc cacgacttga   2100

aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg aactagttat   2160

ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc agtcccccaa   2220

aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg   2280

ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga ctaacggttc   2340

taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga atgccaaaat   2400

cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg   2460

ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg aagactttta   2520

tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg gcattccgag   2580

gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa agcccgaaat   2640

gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa aaataaattc   2700

atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca ttcaggtgac   2760

aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac agctaagaga   2820

acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg gttttcctgt   2880

gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg atggcatgcc   2940

cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga gaaggatctt   3000

agactctgcc gagtttatca aattcacggt cattagacca tttccaggac ttgtgattaa   3060

taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat cagctgaacc   3120

aagccagttg gaagttccag ccacagaagg taaaaggacc tcttccctcc tagggtaaat   3180

cagcttctgt gtcagggatg ctgtgtggtg tccatctgaa ccccctgcat acgcgtagct   3240

aatgtgatct ccccactttc acataagatg gtggccctgc cttcagggaa tgtgggagcc   3300

aggtgggagc cttcccggat atttaagcta gaagattcta cagggagatt ctccttggat   3360

caatatatgt ctctcagtca aagatgtaaa agcacttttg ccttaaaaag aatgttctgt   3420

ttctaaatag agtcaacgtt gtcctcctca ttggaattca ctatgagtca gaatcattag   3480

actgactttt ttttttccat agtaatagta ttttgcagag tctcacagag ctgcagatct   3540

tttgttcatc ttgcagagtt aacaagtctg atcctgttag tccagatttc ttaaatttgg   3600

ccaagttata ataggagcag tagcttgaga cccgaagtca ggaaactttg acaatggatt   3660

ttttttttta atccagagac ttgtactgga atttgcctta ccctgtcagc tcatggactt   3720

aaggtttcat cccgctttat gagtgcttct gaatccaagt cattgttacc tgaatttgca   3780

aattaagttg tgatattcgt gactgttaaa ttcctgtaat tagattaacc tctttgcttg   3840

cttgtttgtt ttctctccta ttttagctta aagtatcagt ggttgagaag agcttttcgg   3900

acctgttact accccaagct gtgtaatata cttgtataac agaaatacct tctatacaaa   3960

cctttttttc tacttttaga tagaaatgtc tactttttca gcagttctgt gaattaaaga   4020

gcagagtgac tgtgggtctg gaatggctgg tgtacttggg aatgtactat caggatttta   4080

cagcaatgct gggaaatgac agggaaaatg acaggaatga atctcaccag attttttatg   4140

tactcagcag agccttgagt tacggtgttt attttccaat caagtgaaga tatctcctac   4200

ttctcctact ggaacatctc agcttctgca gtgaagaaaa attcctgtga tagttcagtt   4260

ctttagtttt tctatttgaa aaaaaaaaat catttaaatg atcctttgtt cacggctctc   4320

cttaatgact gagtgaacag ttcctatctg tatatttgac taaacctttt cctaagctat   4380

ctctcatggt tcctatgttt ttttatcata attaaaagca aaaccatctg gatcacctaa   4440

cagtcagagg tcagtatctc agcgtgtgaa ttatagagga aatacagaga gaacctcttc   4500

cacttttact tttcgtccaa ataaaatgca tggtgtacca gaagttgaag atcgggttga   4560

ggattggggc tagctcgatg acactaaggc cccaacatcg cgggacctgc tgtggcgcgg   4620

attcttagga acgctgttct agccggcccc ctctccaggg gtcgccgtgg ccggcattat   4680

ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg   4740

ctaaggatgc aacctctgac gttctgcgcc ttcctaggag agtcttacat gtgttgagat   4800

ttcacaagca atgcgagttg taaaatacca gctctacaag aagctaggct ctgtgacggc   4860

atagttttca gtagctttat cacaatattc acaatggaga attatatgac atggtagcag   4920

aaataggccc ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat agggtaatca   4980

ataaaatcca tccatgcctt tcacacacta agt                                5013


<210>  4197
<211>  918
<212>  PRT
<213>  Homo sapiens

<400>  4197

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro 
        515                 520                 525


Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu 
    530                 535                 540


Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu 
545                 550                 555                 560


Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro 
                565                 570                 575


Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn 
            580                 585                 590


Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn 
        595                 600                 605


Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn 
    610                 615                 620


Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser 
625                 630                 635                 640


Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp 
                645                 650                 655


Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn 
            660                 665                 670


Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro 
        675                 680                 685


Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu 
    690                 695                 700


Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg 
705                 710                 715                 720


Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys 
                725                 730                 735


Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys 
            740                 745                 750


Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala 
        755                 760                 765


Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp 
    770                 775                 780


Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu 
785                 790                 795                 800


Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met 
                805                 810                 815


Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly 
            820                 825                 830


Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro 
        835                 840                 845


Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu 
    850                 855                 860


Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn 
865                 870                 875                 880


Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu 
                885                 890                 895


Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Gly Lys Arg 
            900                 905                 910


Thr Ser Ser Leu Leu Gly 
        915


<210>  4198
<211>  5016
<212>  DNA
<213>  Homo sapiens

<400>  4198
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   1980

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2040

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2100

tgaaaggatc gtccgcggga gtaataaaat caagttcgtt gttaaaaaac ctgaactagt   2160

tatttcctac ttgcctcctg ggatggctag taaaataaac actaaagctt tgcagtcccc   2220

caaaagacca cgaagtcctg ggagtaattc aaaggttcct gaaattgagg tcaccgtgga   2280

aggccctaat aacaacaatc ctcaaacctc agctgttcga accccgaccc agactaacgg   2340

ttctaacgtt cccttcaagc cacgagggag agagttttcc tttgaggcct ggaatgccaa   2400

aatcacggac ctaaaacaga aagttgaaaa tctcttcaat gagaaatgtg gggaagctct   2460

tggccttaaa caagctgtga aggtgccgtt cgcgttattt gagtctttcc cggaagactt   2520

ttatgtggaa ggcttacctg agggtgtgcc attccgaaga ccatcgactt ttggcattcc   2580

gaggctggag aagatactca gaaacaaagc caaaattaag ttcatcatta aaaagcccga   2640

aatgtttgag acggcgatta aggagagcac ctcctctaag agccctccca gaaaaataaa   2700

ttcatcaccc aatgttaata ctactgcatc aggtgttgaa gaccttaaca tcattcaggt   2760

gacaattcca gatgatgata atgaaagact ctcgaaagtt gaaaaagcta gacagctaag   2820

agaacaagtg aatgacctct ttagtcggaa atttggtgaa gctattggta tgggttttcc   2880

tgtgaaagtt ccctacagga aaatcacaat taaccctggc tgtgtggtgg ttgatggcat   2940

gcccccgggg gtgtccttca aagcccccag ctacctggaa atcagctcca tgagaaggat   3000

cttagactct gccgagttta tcaaattcac ggtcattaga ccatttccag gacttgtgat   3060

taataaccag ctggttgatc agagtgagtc agaaggcccc gtgatacaag aatcagctga   3120

accaagccag ttggaagttc cagccacaga aggtaaaagg acctcttccc tcctagggta   3180

aatcagcttc tgtgtcaggg atgctgtgtg gtgtccatct gaaccccctg catacgcgta   3240

gctaatgtga tctccccact ttcacataag atggtggccc tgccttcagg gaatgtggga   3300

gccaggtggg agccttcccg gatatttaag ctagaagatt ctacagggag attctccttg   3360

gatcaatata tgtctctcag tcaaagatgt aaaagcactt ttgccttaaa aagaatgttc   3420

tgtttctaaa tagagtcaac gttgtcctcc tcattggaat tcactatgag tcagaatcat   3480

tagactgact tttttttttc catagtaata gtattttgca gagtctcaca gagctgcaga   3540

tcttttgttc atcttgcaga gttaacaagt ctgatcctgt tagtccagat ttcttaaatt   3600

tggccaagtt ataataggag cagtagcttg agacccgaag tcaggaaact ttgacaatgg   3660

attttttttt ttaatccaga gacttgtact ggaatttgcc ttaccctgtc agctcatgga   3720

cttaaggttt catcccgctt tatgagtgct tctgaatcca agtcattgtt acctgaattt   3780

gcaaattaag ttgtgatatt cgtgactgtt aaattcctgt aattagatta acctctttgc   3840

ttgcttgttt gttttctctc ctattttagc ttaaagtatc agtggttgag aagagctttt   3900

cggacctgtt actaccccaa gctgtgtaat atacttgtat aacagaaata ccttctatac   3960

aaaccttttt ttctactttt agatagaaat gtctactttt tcagcagttc tgtgaattaa   4020

agagcagagt gactgtgggt ctggaatggc tggtgtactt gggaatgtac tatcaggatt   4080

ttacagcaat gctgggaaat gacagggaaa atgacaggaa tgaatctcac cagatttttt   4140

atgtactcag cagagccttg agttacggtg tttattttcc aatcaagtga agatatctcc   4200

tacttctcct actggaacat ctcagcttct gcagtgaaga aaaattcctg tgatagttca   4260

gttctttagt ttttctattt gaaaaaaaaa aatcatttaa atgatccttt gttcacggct   4320

ctccttaatg actgagtgaa cagttcctat ctgtatattt gactaaacct tttcctaagc   4380

tatctctcat ggttcctatg tttttttatc ataattaaaa gcaaaaccat ctggatcacc   4440

taacagtcag aggtcagtat ctcagcgtgt gaattataga ggaaatacag agagaacctc   4500

ttccactttt acttttcgtc caaataaaat gcatggtgta ccagaagttg aagatcgggt   4560

tgaggattgg ggctagctcg atgacactaa ggccccaaca tcgcgggacc tgctgtggcg   4620

cggattctta ggaacgctgt tctagccggc cccctctcca ggggtcgccg tggccggcat   4680

tatttcctag ttcttcttgt aaccctgagg tgccagcgcg gggagtgagg aggggtcagg   4740

gggctaagga tgcaacctct gacgttctgc gccttcctag gagagtctta catgtgttga   4800

gatttcacaa gcaatgcgag ttgtaaaata ccagctctac aagaagctag gctctgtgac   4860

ggcatagttt tcagtagctt tatcacaata ttcacaatgg agaattatat gacatggtag   4920

cagaaatagg cccttttatg tgttgcttct attttacctc aaattgtaga tatagggtaa   4980

tcaataaaat ccatccatgc ctttcacaca ctaagt                             5016


<210>  4199
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  4199

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile 
        515                 520                 525


Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
545                 550                 555                 560


Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys 
                565                 570                 575


Ser Ser Ser Leu Leu Lys Asn Leu Asn 
            580                 585


<210>  4200
<211>  4207
<212>  DNA
<213>  Homo sapiens

<400>  4200
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1920

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct tagatttgtt   1980

gacagcggtt tcctggagtg ctgtcttgag aacgattctg aggaggctca gcaagaaaga   2040

gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa ctcaagctct tggactcacc   2100

gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc cggagttctt gtatgtggaa   2160

ggcttgccag aggggattcc cttccgaagc cctacctggt ttggaattcc acgacttgaa   2220

aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta aaaaacctga actagttatt   2280

tcctacttgc ctcctgggat ggctagtaaa ataaacacta aagctttgca gtcccccaaa   2340

agaccacgaa gtcctgggag taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc   2400

cctaataaca acaatcctca aacctcagct gttcgaaccc cgacccagac taacggttct   2460

aacgttccct tcaagccacg agggagagag ttttcctttg aggcctggaa tgccaaaatc   2520

acggacctaa aacagaaagt tgaaaatctc ttcaatgaga aatgtgggga agctcttggc   2580

cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt ctttcccgga agacttttat   2640

gtggaaggct tacctgaggg tgtgccattc cgaagaccat cgacttttgg cattccgagg   2700

ctggagaaga tactcagaaa caaagccaaa attaagttca tcattaaaaa gcccgaaatg   2760

tttgagacgg cgattaagga gagcacctcc tctaagagcc ctcccagaaa aataaattca   2820

tcacccaatg ttaatactac tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca   2880

attccagatg atgataatga aagactctcg aaagttgaaa aagctagaca gctaagagaa   2940

caagtgaatg acctctttag tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg   3000

aaagttccct acaggaaaat cacaattaac cctggctgtg tggtggttga tggcatgccc   3060

ccgggggtgt ccttcaaagc ccccagctac ctggaaatca gctccatgag aaggatctta   3120

gactctgccg agtttatcaa attcacggtc attagaccat ttccaggact tgtgattaat   3180

aaccagctgg ttgatcagag tgagtcagaa ggccccgtga tacaagaatc agctgaacca   3240

agccagttgg aagttccagc cacagaagaa ataaaagaga ctgatggaag ctctcagatc   3300

aagcaagaac cagaccccac gtggtagacc tcttccctcc taggagcctt gagttacggt   3360

gtttattttc caatcaagtg aagatatctc ctacttctcc tactggaaca tctcagcttc   3420

tgcagtgaag aaaaattcct gtgatagttc agttctttag tttttctatt tgaaaaaaaa   3480

aaatcattta aatgatcctt tgttcacggc tctccttaat gactgagtga acagttccta   3540

tctgtatatt tgactaaacc ttttcctaag ctatctctca tggttcctat gtttttttat   3600

cataattaaa agcaaaacca tctggatcac ctaacagtca gaggtcagta tctcagcgtg   3660

tgaattatag aggaaataca gagagaacct cttccacttt tacttttcgt ccaaataaaa   3720

tgcatggtgt accagaagtt gaagatcggg ttgaggattg gggctagctc gatgacacta   3780

aggccccaac atcgcgggac ctgctgtggc gcggattctt aggaacgctg ttctagccgg   3840

ccccctctcc aggggtcgcc gtggccggca ttatttccta gttcttcttg taaccctgag   3900

gtgccagcgc ggggagtgag gaggggtcag ggggctaagg atgcaacctc tgacgttctg   3960

cgccttccta ggagagtctt acatgtgttg agatttcaca agcaatgcga gttgtaaaat   4020

accagctcta caagaagcta ggctctgtga cggcatagtt ttcagtagct ttatcacaat   4080

attcacaatg gagaattata tgacatggta gcagaaatag gcccttttat gtgttgcttc   4140

tattttacct caaattgtag atatagggta atcaataaaa tccatccatg cctttcacac   4200

actaagt                                                             4207


<210>  4201
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  4201

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
            500                 505                 510


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
        515                 520


<210>  4202
<211>  7208
<212>  DNA
<213>  Homo sapiens

<400>  4202
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagctca   2040

agctcttgga ctcaccgagg cagtaaaagt accatatcct gtgtttgaat caaacccgga   2100

gttcttgtat gtggaaggct tgccagaggg gattcccttc cgaagcccta cctggtttgg   2160

aattccacga cttgaaagga tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa   2220

acctgaacta gttatttcct acttgcctcc tgggatggct agtaaaataa acactaaagc   2280

tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga   2340

ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc tcagctgttc gaaccccgac   2400

ccagactaac ggttctaacg ttcccttcaa gccacgaggg agagagtttt cctttgaggc   2460

ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa aatctcttca atgagaaatg   2520

tggggaagct cttggcctta aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt   2580

cccggaagac ttttatgtgg aaggcttacc tgagggtgtg ccattccgaa gaccatcgac   2640

ttttggcatt ccgaggctgg agaagatact cagaaacaaa gccaaaatta agttcatcat   2700

taaaaagccc gaaatgtttg agacggcgat taaggagagc acctcctcta agagccctcc   2760

cagaaaaata aattcatcac ccaatgttaa tactactgca tcaggtgttg aagaccttaa   2820

catcattcag gtgacaattc cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc   2880

tagacagcta agagaacaag tgaatgacct ctttagtcgg aaatttggtg aagctattgg   2940

tatgggtttt cctgtgaaag ttccctacag gaaaatcaca attaaccctg gctgtgtggt   3000

ggttgatggc atgcccccgg gggtgtcctt caaagccccc agctacctgg aaatcagctc   3060

catgagaagg atcttagact ctgccgagtt tatcaaattc acggtcatta ggtaagtgag   3120

agtttcctgc ttagtcacag gagcgaatct ggagctcatg aggctgactc ttctaaaatg   3180

cagccacagg tagtcatcga atccggcttc ctatgctgtg caatcaacaa atcaaaataa   3240

cttgtgtcat cattagaatg tcagatgtgc ttctacgaac taagctgact cttttaattc   3300

tttggcaaag ggttggcaaa ctaggactgt ttgccaaatt caggctgcct cctattttta   3360

gagtcttcct gaaacacagc tacacccgta ttatccatgg ctgctttcct gtcacagtga   3420

gtaagtagct gggactgaga aggcatggcc tccaaagtct aaaatattta ctctctagca   3480

ctttgtagaa aaaccttagc taggcacagt ggctaacgcc tgtaatccca gcattttggg   3540

aggccaaggc aggcagatca cctgaggtca ggagttccag accagcctgg ccaacatggt   3600

gaaatcccat ctctacaaaa ataaaacagt tagctgggca tgatggcggg tgcctgtaat   3660

cccagctact cgggaggctg aggcaggata gtcgcttgaa cccaggaggt ggaggttgca   3720

atgagccaag atcatgccac tgcactccag cctggacgac agagtgagac tccatcacaa   3780

gaaaaaaaga actttgtcaa cctctgtctt agggcgcctt gtcacaggct tcgggtcaga   3840

cggattcaac cttgcatcag ccatttgtta gccaggtcac tctgttcttt gtctgtaaat   3900

gagattgatc gttgttccca ctgagagtgt cagctccttc ccgtagagca ggcatgatga   3960

ttgtactcac ctctgacacc attgtgagtg ccacattcct tcccacgtcc ttgtcactgt   4020

aagagatgcc cacctgagca ccaaccccag gttatcttcc cctttgtctt ccagcccccc   4080

agaaacagct acgactcaac ctacccaatc atttcatcat cagattgcca ctgtctctag   4140

ttcaggtctc ttgggactgg cactcagaaa tctcataata aatcctcttg aggcttctca   4200

tacactcgtc ttcttccaat cttctttccc tcaaaatctc atattttggt tccacttcac   4260

ccaccgtcat tctccatatc actcccagga gttaggcaaa aagccccttc cgttcttccg   4320

tatgttaaac ttagaatcac tctgttccct gctctgcgtt tctatttttt gtttttcctc   4380

catttactag tagcttaaca ctttctaaca gtgttcttat tattgatacg tatctatctc   4440

ttccataagc ttataaggtc acggataata cttctcattg tagtacgtaa atgacgtggg   4500

ctagatatga gttgaataaa cagttatacc tgtaaattct tacagagtga aaataaattg   4560

ttatacttta caatttgttt ctctctttag accatttcca ggacttgtga ttaataaccg   4620

tgagtatttt gtgaagtgtt ttgtttttgt tttttcctgg ggtctgacgt gtgtgcgtgt   4680

gagtgtgtat acatgcttaa cgtatatcac gttacttcac ctatgtcagt aaccaggcca   4740

aatacttgtt ttagccctca gtaaaaacac caggcacttc ctagttgtaa aattattcaa   4800

gcttcttaac ttcctatcct cgatgcactt aatcataaaa tggtaataat agcaccgatt   4860

ttgggggagt cgttccagta gatggaaagc atctggaaca ggtgtcagca agctcctgcc   4920

gacgtgtatg cataaagttt tattgaaacc accatcgtgt ccatttgttt atggcagaac   4980

tgagagatgg cagcagcaag tgtgtgcctg caaaacctaa aatatttact aattggctct   5040

gcaagaaaag agtttgcatc cccctaacct agaacagtgt ctagcctcta gtatgtgttt   5100

agcctacagt atgtgctcag cgaatacaat ctatatttat tactgctttt atgactgtta   5160

taattactgt gcttggattt cgttacaaag taagtcacaa tgtgcctgct tctgttagta   5220

tttcagcaca gtgcctggca cacatggggc tctcaaatat tgctgagcga gtgaacaaat   5280

gtcctttcaa ttccttaacg ttgatgtcat tttcaatagt attttgagcc aaacttaatt   5340

ttgcgagtgt gttttgtttt cttaacttta ttattaaaaa tgtataaaag tgaggccagg   5400

cgtggtggct cacgcctgta atcccagcag tttgggaggc tgaggcaggc ggatcagttg   5460

aggttgggag ttggagacca gcccgtccaa catggtgaaa gcctgtctct actaaaaata   5520

caaaaatcag ctgggtgtgg tggcgcgtgc ctgtaatccc agctactcag gaggctgagg   5580

caggagagtt gcttgaatcc tagaggtgga ggttgcagtg agctgagatc gtgccattgc   5640

actccagcct gggcaacaag agcaaaactc tgtcccaata aataaataaa taaaatgttc   5700

tcttttgttc ctgttcttgt gcggtagtgt ggtatagagt tttatggtaa ttactgtgaa   5760

ttagtgattc tgagggacat atcagaactc tgaggtttgt ttccttctca tcttgaggga   5820

aacagcaaat gtatgttaaa atgcttttcc aagggaacaa cacatcctta cattatttaa   5880

accaatctgc ttcattttca gagctggttg atcagagtga gtcagaaggc cccgtgatac   5940

aagaatcagc tgaaccaagc cagttggaag ttccagccac agaagaaata aaagagactg   6000

atggaagctc tcagatcaag caagaaccag accccacgtg gtagacctct tccctcctag   6060

gcttaaagta tcagtggttg agaagagctt ttcggacctg ttactacccc aagctgtgta   6120

atatacttgt ataacagaaa taccttctat acaaaccttt ttttctactt ttagatagaa   6180

atgtctactt tttcagcagt tctgtgaatt aaagagcaga gtgactgtgg gtctggaatg   6240

gctggtgtac ttgggaatgt actatcagga ttttacagca atgctgggaa atgacaggga   6300

aaatgacagg aatgaatctc accagatttt ttatgtactc agcagagcct tgagttacgg   6360

tgtttatttt ccaatcaagt gaagatatct cctacttctc ctactggaac atctcagctt   6420

ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa   6480

aaaatcattt aaatgatcct ttgttcacgg ctctccttaa tgactgagtg aacagttcct   6540

atctgtatat ttgactaaac cttttcctaa gctatctctc atggttccta tgttttttta   6600

tcataattaa aagcaaaacc atctggatca cctaacagtc agaggtcagt atctcagcgt   6660

gtgaattata gaggaaatac agagagaacc tcttccactt ttacttttcg tccaaataaa   6720

atgcatggtg taccagaagt tgaagatcgg gttgaggatt ggggctagct cgatgacact   6780

aaggccccaa catcgcggga cctgctgtgg cgcggattct taggaacgct gttctagccg   6840

gccccctctc caggggtcgc cgtggccggc attatttcct agttcttctt gtaaccctga   6900

ggtgccagcg cggggagtga ggaggggtca gggggctaag gatgcaacct ctgacgttct   6960

gcgccttcct aggagagtct tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa   7020

taccagctct acaagaagct aggctctgtg acggcatagt tttcagtagc tttatcacaa   7080

tattcacaat ggagaattat atgacatggt agcagaaata ggccctttta tgtgttgctt   7140

ctattttacc tcaaattgta gatatagggt aatcaataaa atccatccat gcctttcaca   7200

cactaagt                                                            7208


<210>  4203
<211>  897
<212>  PRT
<213>  Homo sapiens

<400>  4203

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu 
    530                 535                 540


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
545                 550                 555                 560


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
                565                 570                 575


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
            580                 585                 590


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
        595                 600                 605


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
    610                 615                 620


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
625                 630                 635                 640


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
                645                 650                 655


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
            660                 665                 670


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
        675                 680                 685


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
    690                 695                 700


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
705                 710                 715                 720


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
                725                 730                 735


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
            740                 745                 750


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
        755                 760                 765


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
    770                 775                 780


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
785                 790                 795                 800


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
                805                 810                 815


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
            820                 825                 830


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
        835                 840                 845


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
    850                 855                 860


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
865                 870                 875                 880


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
                885                 890                 895


Arg 



<210>  4204
<211>  5192
<212>  DNA
<213>  Homo sapiens

<400>  4204
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1980

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct tagatttgtt   2040

gacagcggtt tcctggagtg ctgtcttgag aacgattctg aggaggctca gcaagaaaga   2100

gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa ctcaagctct tggactcacc   2160

gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc cggagttctt gtatgtggaa   2220

ggcttgccag aggggattcc cttccgaagc cctacctggt ttggaattcc acgacttgaa   2280

aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta aaaaacctga actagttatt   2340

tcctacttgc ctcctgggat ggctagtaaa ataaacacta aagctttgca gtcccccaaa   2400

agaccacgaa gtcctgggag taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc   2460

cctaataaca acaatcctca aacctcagct gttcgaaccc cgacccagac taacggttct   2520

aacgttccct tcaagccacg agggagagag ttttcctttg aggcctggaa tgccaaaatc   2580

acggacctaa aacagaaagt tgaaaatctc ttcaatgaga aatgtgggga agctcttggc   2640

cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt ctttcccgga agacttttat   2700

gtggaaggct tacctgaggg tgtgccattc cgaagaccat cgacttttgg cattccgagg   2760

ctggagaaga tactcagaaa caaagccaaa attaagttca tcattaaaaa gcccgaaatg   2820

tttgagacgg cgattaagga gagcacctcc tctaagagcc ctcccagaaa aataaattca   2880

tcacccaatg ttaatactac tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca   2940

attccagatg atgataatga aagactctcg aaagttgaaa aagctagaca gctaagagaa   3000

caagtgaatg acctctttag tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg   3060

aaagttccct acaggaaaat cacaattaac cctggctgtg tggtggttga tggcatgccc   3120

ccgggggtgt ccttcaaagc ccccagctac ctggaaatca gctccatgag aaggatctta   3180

gactctgccg agtttatcaa attcacggtc attagaccat ttccaggact tgtgattaat   3240

aaccagctgg ttgatcagag tgagtcagaa ggccccgtga tacaagaatc agctgaacca   3300

agccagttgg aagttccagc cacagaaggt aaaaggacct cttccctcct agggtaaatc   3360

agcttctgtg tcagggatgc tgtgtggtgt ccatctgaac cccctgcata cgcgtagcta   3420

atgtgatctc cccactttca cataagatgg tggccctgcc ttcagggaat gtgggagcca   3480

ggtgggagcc ttcccggata tttaagctag aagattctac agggagattc tccttggatc   3540

aatatatgtc tctcagtcaa agatgtaaaa gcacttttgc cttaaaaaga atgttctgtt   3600

tctaaataga gtcaacgttg tcctcctcat tggaattcac tatgagtcag aatcattaga   3660

ctgacttttt tttttccata gtaatagtat tttgcagagt ctcacagagc tgcagatctt   3720

ttgttcatct tgcagagtta acaagtctga tcctgttagt ccagatttct taaatttggc   3780

caagttataa taggagcagt agcttgagac ccgaagtcag gaaactttga caatggattt   3840

ttttttttaa tccagagact tgtactggaa tttgccttac cctgtcagct catggactta   3900

aggtttcatc ccgctttatg agtgcttctg aatccaagtc attgttacct gaatttgcaa   3960

attaagttgt gatattcgtg actgttaaat tcctgtaatt agattaacct ctttgcttgc   4020

ttgtttgttt tctctcctat tttagcttaa agtatcagtg gttgagaaga gcttttcgga   4080

cctgttacta ccccaagctg tgtaatatac ttgtataaca gaaatacctt ctatacaaac   4140

ctttttttct acttttagat agaaatgtct actttttcag cagttctgtg aattaaagag   4200

cagagtgact gtgggtctgg aatggctggt gtacttggga atgtactatc aggattttac   4260

agcaatgctg ggaaatgaca gggaaaatga caggaatgaa tctcaccaga ttttttatgt   4320

actcagcaga gccttgagtt acggtgttta ttttccaatc aagtgaagat atctcctact   4380

tctcctactg gaacatctca gcttctgcag tgaagaaaaa ttcctgtgat agttcagttc   4440

tttagttttt ctatttgaaa aaaaaaaatc atttaaatga tcctttgttc acggctctcc   4500

ttaatgactg agtgaacagt tcctatctgt atatttgact aaaccttttc ctaagctatc   4560

tctcatggtt cctatgtttt tttatcataa ttaaaagcaa aaccatctgg atcacctaac   4620

agtcagaggt cagtatctca gcgtgtgaat tatagaggaa atacagagag aacctcttcc   4680

acttttactt ttcgtccaaa taaaatgcat ggtgtaccag aagttgaaga tcgggttgag   4740

gattggggct agctcgatga cactaaggcc ccaacatcgc gggacctgct gtggcgcgga   4800

ttcttaggaa cgctgttcta gccggccccc tctccagggg tcgccgtggc cggcattatt   4860

tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc   4920

taaggatgca acctctgacg ttctgcgcct tcctaggaga gtcttacatg tgttgagatt   4980

tcacaagcaa tgcgagttgt aaaataccag ctctacaaga agctaggctc tgtgacggca   5040

tagttttcag tagctttatc acaatattca caatggagaa ttatatgaca tggtagcaga   5100

aataggccct tttatgtgtt gcttctattt tacctcaaat tgtagatata gggtaatcaa   5160

taaaatccat ccatgccttt cacacactaa gt                                 5192


<210>  4205
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  4205

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  4206
<211>  4155
<212>  DNA
<213>  Homo sapiens

<400>  4206
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1980

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   2040

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttgt   2100

atgtggaagg cttgccagag gggattccct tccgaagccc tacctggttt ggaattccac   2160

gacttgaaag gatcgtccgc gggagtaata aaatcaagtt cgttgttaaa aaacctgaac   2220

tagttatttc ctacttgcct cctgggatgg ctagtaaaat aaacactaaa gctttgcagt   2280

cccccaaaag accacgaagt cctgggagta attcaaaggt tcctgaaatt gaggtcaccg   2340

tggaaggccc taataacaac aatcctcaaa cctcagctgt tcgaaccccg acccagacta   2400

acggttctaa cgttcccttc aagccacgag ggagagagtt ttcctttgag gcctggaatg   2460

ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt caatgagaaa tgtggggaag   2520

ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt atttgagtct ttcccggaag   2580

acttttatgt ggaaggctta cctgagggtg tgccattccg aagaccatcg acttttggca   2640

ttccgaggct ggagaagata ctcagaaaca aagccaaaat taagttcatc attaaaaagc   2700

ccgaaatgtt tgagacggcg attaaggaga gcacctcctc taagagccct cccagaaaaa   2760

taaattcatc acccaatgtt aatactactg catcaggtgt tgaagacctt aacatcattc   2820

aggtgacaat tccagatgat gataatgaaa gactctcgaa agttgaaaaa gctagacagc   2880

taagagaaca agtgaatgac ctctttagtc ggaaatttgg tgaagctatt ggtatgggtt   2940

ttcctgtgaa agttccctac aggaaaatca caattaaccc tggctgtgtg gtggttgatg   3000

gcatgccccc gggggtgtcc ttcaaagccc ccagctacct ggaaatcagc tccatgagaa   3060

ggatcttaga ctctgccgag tttatcaaat tcacggtcat tagaccattt ccaggacttg   3120

tgattaataa ccagctggtt gatcagagtg agtcagaagg ccccgtgata caagaatcag   3180

ctgaaccaag ccagttggaa gttccagcca cagaagaaat aaaagagact gatggaagct   3240

ctcagatcaa gcaagaacca gaccccacgt ggtagacctc ttccctccta ggagccttga   3300

gttacggtgt ttattttcca atcaagtgaa gatatctcct acttctccta ctggaacatc   3360

tcagcttctg cagtgaagaa aaattcctgt gatagttcag ttctttagtt tttctatttg   3420

aaaaaaaaaa atcatttaaa tgatcctttg ttcacggctc tccttaatga ctgagtgaac   3480

agttcctatc tgtatatttg actaaacctt ttcctaagct atctctcatg gttcctatgt   3540

ttttttatca taattaaaag caaaaccatc tggatcacct aacagtcaga ggtcagtatc   3600

tcagcgtgtg aattatagag gaaatacaga gagaacctct tccactttta cttttcgtcc   3660

aaataaaatg catggtgtac cagaagttga agatcgggtt gaggattggg gctagctcga   3720

tgacactaag gccccaacat cgcgggacct gctgtggcgc ggattcttag gaacgctgtt   3780

ctagccggcc ccctctccag gggtcgccgt ggccggcatt atttcctagt tcttcttgta   3840

accctgaggt gccagcgcgg ggagtgagga ggggtcaggg ggctaaggat gcaacctctg   3900

acgttctgcg ccttcctagg agagtcttac atgtgttgag atttcacaag caatgcgagt   3960

tgtaaaatac cagctctaca agaagctagg ctctgtgacg gcatagtttt cagtagcttt   4020

atcacaatat tcacaatgga gaattatatg acatggtagc agaaataggc ccttttatgt   4080

gttgcttcta ttttacctca aattgtagat atagggtaat caataaaatc catccatgcc   4140

tttcacacac taagt                                                    4155


<210>  4207
<211>  957
<212>  PRT
<213>  Homo sapiens

<400>  4207

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
                565                 570                 575


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
            580                 585                 590


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
        595                 600                 605


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
    610                 615                 620


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
625                 630                 635                 640


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
                645                 650                 655


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
            660                 665                 670


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
        675                 680                 685


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
    690                 695                 700


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
705                 710                 715                 720


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
                725                 730                 735


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
            740                 745                 750


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
        755                 760                 765


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
    770                 775                 780


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
785                 790                 795                 800


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
                805                 810                 815


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
            820                 825                 830


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
        835                 840                 845


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
    850                 855                 860


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
865                 870                 875                 880


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
                885                 890                 895


Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu 
            900                 905                 910


Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu 
        915                 920                 925


Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp 
    930                 935                 940


Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950                 955


<210>  4208
<211>  7112
<212>  DNA
<213>  Homo sapiens

<400>  4208
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040

taccatatcc tgtgtttgaa tcaaacccgg agttcttgaa aggatcgtcc gcgggagtaa   2100

taaaatcaag ttcgttgtta aaaaacctga actagttatt tcctacttgc ctcctgggat   2160

ggctagtaaa ataaacacta aagctttgca gtcccccaaa agaccacgaa gtcctgggag   2220

taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc cctaataaca acaatcctca   2280

aacctcagct gttcgaaccc cgacccagac taacggttct aacgttccct tcaagccacg   2340

agggagagag ttttcctttg aggcctggaa tgccaaaatc acggacctaa aacagaaagt   2400

tgaaaatctc ttcaatgaga aatgtgggga agctcttggc cttaaacaag ctgtgaaggt   2460

gccgttcgcg ttatttgagt ctttcccgga agacttttat gtggaaggct tacctgaggg   2520

tgtgccattc cgaagaccat cgacttttgg cattccgagg ctggagaaga tactcagaaa   2580

caaagccaaa attaagttca tcattaaaaa gcccgaaatg tttgagacgg cgattaagga   2640

gagcacctcc tctaagagcc ctcccagaaa aataaattca tcacccaatg ttaatactac   2700

tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca attccagatg atgataatga   2760

aagactctcg aaagttgaaa aagctagaca gctaagagaa caagtgaatg acctctttag   2820

tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg aaagttccct acaggaaaat   2880

cacaattaac cctggctgtg tggtggttga tggcatgccc ccgggggtgt ccttcaaagc   2940

ccccagctac ctggaaatca gctccatgag aaggatctta gactctgccg agtttatcaa   3000

attcacggtc attaggtaag tgagagtttc ctgcttagtc acaggagcga atctggagct   3060

catgaggctg actcttctaa aatgcagcca caggtagtca tcgaatccgg cttcctatgc   3120

tgtgcaatca acaaatcaaa ataacttgtg tcatcattag aatgtcagat gtgcttctac   3180

gaactaagct gactctttta attctttggc aaagggttgg caaactagga ctgtttgcca   3240

aattcaggct gcctcctatt tttagagtct tcctgaaaca cagctacacc cgtattatcc   3300

atggctgctt tcctgtcaca gtgagtaagt agctgggact gagaaggcat ggcctccaaa   3360

gtctaaaata tttactctct agcactttgt agaaaaacct tagctaggca cagtggctaa   3420

cgcctgtaat cccagcattt tgggaggcca aggcaggcag atcacctgag gtcaggagtt   3480

ccagaccagc ctggccaaca tggtgaaatc ccatctctac aaaaataaaa cagttagctg   3540

ggcatgatgg cgggtgcctg taatcccagc tactcgggag gctgaggcag gatagtcgct   3600

tgaacccagg aggtggaggt tgcaatgagc caagatcatg ccactgcact ccagcctgga   3660

cgacagagtg agactccatc acaagaaaaa aagaactttg tcaacctctg tcttagggcg   3720

ccttgtcaca ggcttcgggt cagacggatt caaccttgca tcagccattt gttagccagg   3780

tcactctgtt ctttgtctgt aaatgagatt gatcgttgtt cccactgaga gtgtcagctc   3840

cttcccgtag agcaggcatg atgattgtac tcacctctga caccattgtg agtgccacat   3900

tccttcccac gtccttgtca ctgtaagaga tgcccacctg agcaccaacc ccaggttatc   3960

ttcccctttg tcttccagcc ccccagaaac agctacgact caacctaccc aatcatttca   4020

tcatcagatt gccactgtct ctagttcagg tctcttggga ctggcactca gaaatctcat   4080

aataaatcct cttgaggctt ctcatacact cgtcttcttc caatcttctt tccctcaaaa   4140

tctcatattt tggttccact tcacccaccg tcattctcca tatcactccc aggagttagg   4200

caaaaagccc cttccgttct tccgtatgtt aaacttagaa tcactctgtt ccctgctctg   4260

cgtttctatt ttttgttttt cctccattta ctagtagctt aacactttct aacagtgttc   4320

ttattattga tacgtatcta tctcttccat aagcttataa ggtcacggat aatacttctc   4380

attgtagtac gtaaatgacg tgggctagat atgagttgaa taaacagtta tacctgtaaa   4440

ttcttacaga gtgaaaataa attgttatac tttacaattt gtttctctct ttagaccatt   4500

tccaggactt gtgattaata accgtgagta ttttgtgaag tgttttgttt ttgttttttc   4560

ctggggtctg acgtgtgtgc gtgtgagtgt gtatacatgc ttaacgtata tcacgttact   4620

tcacctatgt cagtaaccag gccaaatact tgttttagcc ctcagtaaaa acaccaggca   4680

cttcctagtt gtaaaattat tcaagcttct taacttccta tcctcgatgc acttaatcat   4740

aaaatggtaa taatagcacc gattttgggg gagtcgttcc agtagatgga aagcatctgg   4800

aacaggtgtc agcaagctcc tgccgacgtg tatgcataaa gttttattga aaccaccatc   4860

gtgtccattt gtttatggca gaactgagag atggcagcag caagtgtgtg cctgcaaaac   4920

ctaaaatatt tactaattgg ctctgcaaga aaagagtttg catcccccta acctagaaca   4980

gtgtctagcc tctagtatgt gtttagccta cagtatgtgc tcagcgaata caatctatat   5040

ttattactgc ttttatgact gttataatta ctgtgcttgg atttcgttac aaagtaagtc   5100

acaatgtgcc tgcttctgtt agtatttcag cacagtgcct ggcacacatg gggctctcaa   5160

atattgctga gcgagtgaac aaatgtcctt tcaattcctt aacgttgatg tcattttcaa   5220

tagtattttg agccaaactt aattttgcga gtgtgttttg ttttcttaac tttattatta   5280

aaaatgtata aaagtgaggc caggcgtggt ggctcacgcc tgtaatccca gcagtttggg   5340

aggctgaggc aggcggatca gttgaggttg ggagttggag accagcccgt ccaacatggt   5400

gaaagcctgt ctctactaaa aatacaaaaa tcagctgggt gtggtggcgc gtgcctgtaa   5460

tcccagctac tcaggaggct gaggcaggag agttgcttga atcctagagg tggaggttgc   5520

agtgagctga gatcgtgcca ttgcactcca gcctgggcaa caagagcaaa actctgtccc   5580

aataaataaa taaataaaat gttctctttt gttcctgttc ttgtgcggta gtgtggtata   5640

gagttttatg gtaattactg tgaattagtg attctgaggg acatatcaga actctgaggt   5700

ttgtttcctt ctcatcttga gggaaacagc aaatgtatgt taaaatgctt ttccaaggga   5760

acaacacatc cttacattat ttaaaccaat ctgcttcatt ttcagagctg gttgatcaga   5820

gtgagtcaga aggccccgtg atacaagaat cagctgaacc aagccagttg gaagttccag   5880

ccacagaaga aataaaagag actgatggaa gctctcagat caagcaagaa ccagacccca   5940

cgtggtagac ctcttccctc ctaggcttaa agtatcagtg gttgagaaga gcttttcgga   6000

cctgttacta ccccaagctg tgtaatatac ttgtataaca gaaatacctt ctatacaaac   6060

ctttttttct acttttagat agaaatgtct actttttcag cagttctgtg aattaaagag   6120

cagagtgact gtgggtctgg aatggctggt gtacttggga atgtactatc aggattttac   6180

agcaatgctg ggaaatgaca gggaaaatga caggaatgaa tctcaccaga ttttttatgt   6240

actcagcaga gccttgagtt acggtgttta ttttccaatc aagtgaagat atctcctact   6300

tctcctactg gaacatctca gcttctgcag tgaagaaaaa ttcctgtgat agttcagttc   6360

tttagttttt ctatttgaaa aaaaaaaatc atttaaatga tcctttgttc acggctctcc   6420

ttaatgactg agtgaacagt tcctatctgt atatttgact aaaccttttc ctaagctatc   6480

tctcatggtt cctatgtttt tttatcataa ttaaaagcaa aaccatctgg atcacctaac   6540

agtcagaggt cagtatctca gcgtgtgaat tatagaggaa atacagagag aacctcttcc   6600

acttttactt ttcgtccaaa taaaatgcat ggtgtaccag aagttgaaga tcgggttgag   6660

gattggggct agctcgatga cactaaggcc ccaacatcgc gggacctgct gtggcgcgga   6720

ttcttaggaa cgctgttcta gccggccccc tctccagggg tcgccgtggc cggcattatt   6780

tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc   6840

taaggatgca acctctgacg ttctgcgcct tcctaggaga gtcttacatg tgttgagatt   6900

tcacaagcaa tgcgagttgt aaaataccag ctctacaaga agctaggctc tgtgacggca   6960

tagttttcag tagctttatc acaatattca caatggagaa ttatatgaca tggtagcaga   7020

aataggccct tttatgtgtt gcttctattt tacctcaaat tgtagatata gggtaatcaa   7080

taaaatccat ccatgccttt cacacactaa gt                                 7112


<210>  4209
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  4209

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
    450                 455                 460


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
465                 470                 475                 480


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
                485                 490                 495


Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu 
            500                 505                 510


Lys Asn Leu Asn 
        515


<210>  4210
<211>  7796
<212>  DNA
<213>  Homo sapiens

<400>  4210
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agctcaagct cttggactca ccgaggcagt aaaagtacca tatcctgtgt   1980

ttgaatcaaa cccggagttc ttgtatgtgg aaggcttgcc agaggggatt cccttccgaa   2040

gccctacctg gtttggaatt ccacgacttg aaaggatcgt ccgcgggagt aataaaatca   2100

agttcgttgt taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta   2160

aaataaacac taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa   2220

aggttcctga aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag   2280

ctgttcgaac cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag   2340

agttttcctt tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc   2400

tcttcaatga gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg   2460

cgttatttga gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat   2520

tccgaagacc atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca   2580

aaattaagtt catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct   2640

cctctaagag ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag   2700

gtgttgaaga ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct   2760

cgaaagttga aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat   2820

ttggtgaagc tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta   2880

accctggctg tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct   2940

acctggaaat cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg   3000

tcattaggta agtgagagtt tcctgcttag tcacaggagc gaatctggag ctcatgaggc   3060

tgactcttct aaaatgcagc cacaggtagt catcgaatcc ggcttcctat gctgtgcaat   3120

caacaaatca aaataacttg tgtcatcatt agaatgtcag atgtgcttct acgaactaag   3180

ctgactcttt taattctttg gcaaagggtt ggcaaactag gactgtttgc caaattcagg   3240

ctgcctccta tttttagagt cttcctgaaa cacagctaca cccgtattat ccatggctgc   3300

tttcctgtca cagtgagtaa gtagctggga ctgagaaggc atggcctcca aagtctaaaa   3360

tatttactct ctagcacttt gtagaaaaac cttagctagg cacagtggct aacgcctgta   3420

atcccagcat tttgggaggc caaggcaggc agatcacctg aggtcaggag ttccagacca   3480

gcctggccaa catggtgaaa tcccatctct acaaaaataa aacagttagc tgggcatgat   3540

ggcgggtgcc tgtaatccca gctactcggg aggctgaggc aggatagtcg cttgaaccca   3600

ggaggtggag gttgcaatga gccaagatca tgccactgca ctccagcctg gacgacagag   3660

tgagactcca tcacaagaaa aaaagaactt tgtcaacctc tgtcttaggg cgccttgtca   3720

caggcttcgg gtcagacgga ttcaaccttg catcagccat ttgttagcca ggtcactctg   3780

ttctttgtct gtaaatgaga ttgatcgttg ttcccactga gagtgtcagc tccttcccgt   3840

agagcaggca tgatgattgt actcacctct gacaccattg tgagtgccac attccttccc   3900

acgtccttgt cactgtaaga gatgcccacc tgagcaccaa ccccaggtta tcttcccctt   3960

tgtcttccag ccccccagaa acagctacga ctcaacctac ccaatcattt catcatcaga   4020

ttgccactgt ctctagttca ggtctcttgg gactggcact cagaaatctc ataataaatc   4080

ctcttgaggc ttctcataca ctcgtcttct tccaatcttc tttccctcaa aatctcatat   4140

tttggttcca cttcacccac cgtcattctc catatcactc ccaggagtta ggcaaaaagc   4200

cccttccgtt cttccgtatg ttaaacttag aatcactctg ttccctgctc tgcgtttcta   4260

ttttttgttt ttcctccatt tactagtagc ttaacacttt ctaacagtgt tcttattatt   4320

gatacgtatc tatctcttcc ataagcttat aaggtcacgg ataatacttc tcattgtagt   4380

acgtaaatga cgtgggctag atatgagttg aataaacagt tatacctgta aattcttaca   4440

gagtgaaaat aaattgttat actttacaat ttgtttctct ctttagacca tttccaggac   4500

ttgtgattaa taaccgtgag tattttgtga agtgttttgt ttttgttttt tcctggggtc   4560

tgacgtgtgt gcgtgtgagt gtgtatacat gcttaacgta tatcacgtta cttcacctat   4620

gtcagtaacc aggccaaata cttgttttag ccctcagtaa aaacaccagg cacttcctag   4680

ttgtaaaatt attcaagctt cttaacttcc tatcctcgat gcacttaatc ataaaatggt   4740

aataatagca ccgattttgg gggagtcgtt ccagtagatg gaaagcatct ggaacaggtg   4800

tcagcaagct cctgccgacg tgtatgcata aagttttatt gaaaccacca tcgtgtccat   4860

ttgtttatgg cagaactgag agatggcagc agcaagtgtg tgcctgcaaa acctaaaata   4920

tttactaatt ggctctgcaa gaaaagagtt tgcatccccc taacctagaa cagtgtctag   4980

cctctagtat gtgtttagcc tacagtatgt gctcagcgaa tacaatctat atttattact   5040

gcttttatga ctgttataat tactgtgctt ggatttcgtt acaaagtaag tcacaatgtg   5100

cctgcttctg ttagtatttc agcacagtgc ctggcacaca tggggctctc aaatattgct   5160

gagcgagtga acaaatgtcc tttcaattcc ttaacgttga tgtcattttc aatagtattt   5220

tgagccaaac ttaattttgc gagtgtgttt tgttttctta actttattat taaaaatgta   5280

taaaagtgag gccaggcgtg gtggctcacg cctgtaatcc cagcagtttg ggaggctgag   5340

gcaggcggat cagttgaggt tgggagttgg agaccagccc gtccaacatg gtgaaagcct   5400

gtctctacta aaaatacaaa aatcagctgg gtgtggtggc gcgtgcctgt aatcccagct   5460

actcaggagg ctgaggcagg agagttgctt gaatcctaga ggtggaggtt gcagtgagct   5520

gagatcgtgc cattgcactc cagcctgggc aacaagagca aaactctgtc ccaataaata   5580

aataaataaa atgttctctt ttgttcctgt tcttgtgcgg tagtgtggta tagagtttta   5640

tggtaattac tgtgaattag tgattctgag ggacatatca gaactctgag gtttgtttcc   5700

ttctcatctt gagggaaaca gcaaatgtat gttaaaatgc ttttccaagg gaacaacaca   5760

tccttacatt atttaaacca atctgcttca ttttcagagc tggttgatca gagtgagtca   5820

gaaggccccg tgatacaaga atcagctgaa ccaagccagt tggaagttcc agccacagaa   5880

gaaataaaag agactgatgg aagctctcag atcaagcaag aaccagaccc cacgtggtag   5940

acctcttccc tcctagggta aatcagcttc tgtgtcaggg atgctgtgtg gtgtccatct   6000

gaaccccctg catacgcgta gctaatgtga tctccccact ttcacataag atggtggccc   6060

tgccttcagg gaatgtggga gccaggtggg agccttcccg gatatttaag ctagaagatt   6120

ctacagggag attctccttg gatcaatata tgtctctcag tcaaagatgt aaaagcactt   6180

ttgccttaaa aagaatgttc tgtttctaaa tagagtcaac gttgtcctcc tcattggaat   6240

tcactatgag tcagaatcat tagactgact tttttttttc catagtaata gtattttgca   6300

gagtctcaca gagctgcaga tcttttgttc atcttgcaga gttaacaagt ctgatcctgt   6360

tagtccagat ttcttaaatt tggccaagtt ataataggag cagtagcttg agacccgaag   6420

tcaggaaact ttgacaatgg attttttttt ttaatccaga gacttgtact ggaatttgcc   6480

ttaccctgtc agctcatgga cttaaggttt catcccgctt tatgagtgct tctgaatcca   6540

agtcattgtt acctgaattt gcaaattaag ttgtgatatt cgtgactgtt aaattcctgt   6600

aattagatta acctctttgc ttgcttgttt gttttctctc ctattttagc ttaaagtatc   6660

agtggttgag aagagctttt cggacctgtt actaccccaa gctgtgtaat atacttgtat   6720

aacagaaata ccttctatac aaaccttttt ttctactttt agatagaaat gtctactttt   6780

tcagcagttc tgtgaattaa agagcagagt gactgtgggt ctggaatggc tggtgtactt   6840

gggaatgtac tatcaggatt ttacagcaat gctgggaaat gacagggaaa atgacaggaa   6900

tgaatctcac cagatttttt atgtactcag cagagccttg agttacggtg tttattttcc   6960

aatcaagtga agatatctcc tacttctcct actggaacat ctcagcttct gcagtgaaga   7020

aaaattcctg tgatagttca gttctttagt ttttctattt gaaaaaaaaa aatcatttaa   7080

atgatccttt gttcacggct ctccttaatg actgagtgaa cagttcctat ctgtatattt   7140

gactaaacct tttcctaagc tatctctcat ggttcctatg tttttttatc ataattaaaa   7200

gcaaaaccat ctggatcacc taacagtcag aggtcagtat ctcagcgtgt gaattataga   7260

ggaaatacag agagaacctc ttccactttt acttttcgtc caaataaaat gcatggtgta   7320

ccagaagttg aagatcgggt tgaggattgg ggctagctcg atgacactaa ggccccaaca   7380

tcgcgggacc tgctgtggcg cggattctta ggaacgctgt tctagccggc cccctctcca   7440

ggggtcgccg tggccggcat tatttcctag ttcttcttgt aaccctgagg tgccagcgcg   7500

gggagtgagg aggggtcagg gggctaagga tgcaacctct gacgttctgc gccttcctag   7560

gagagtctta catgtgttga gatttcacaa gcaatgcgag ttgtaaaata ccagctctac   7620

aagaagctag gctctgtgac ggcatagttt tcagtagctt tatcacaata ttcacaatgg   7680

agaattatat gacatggtag cagaaatagg cccttttatg tgttgcttct attttacctc   7740

aaattgtaga tatagggtaa tcaataaaat ccatccatgc ctttcacaca ctaagt       7796


<210>  4211
<211>  808
<212>  PRT
<213>  Homo sapiens

<400>  4211

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro 
    450                 455                 460


Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu 
465                 470                 475                 480


Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu 
                485                 490                 495


Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro 
            500                 505                 510


Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn 
        515                 520                 525


Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn 
    530                 535                 540


Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn 
545                 550                 555                 560


Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser 
                565                 570                 575


Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp 
            580                 585                 590


Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn 
        595                 600                 605


Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro 
    610                 615                 620


Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu 
625                 630                 635                 640


Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg 
                645                 650                 655


Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys 
            660                 665                 670


Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys 
        675                 680                 685


Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala 
    690                 695                 700


Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp 
705                 710                 715                 720


Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu 
                725                 730                 735


Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met 
            740                 745                 750


Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly 
        755                 760                 765


Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro 
    770                 775                 780


Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu 
785                 790                 795                 800


Phe Ile Lys Phe Thr Val Ile Arg 
                805


<210>  4212
<211>  4960
<212>  DNA
<213>  Homo sapiens

<400>  4212
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagctc   1860

aagctcttgg actcaccgag gcagtaaaag taccatatcc tgtgtttgaa tcaaacccgg   1920

agttcttgta tgtggaaggc ttgccagagg ggattccctt ccgaagccct acctggtttg   1980

gaattccacg acttgaaagg atcgtccgcg ggagtaataa aatcaagttc gttgttaaaa   2040

aacctgaact agttatttcc tacttgcctc ctgggatggc tagtaaaata aacactaaag   2100

ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa ttcaaaggtt cctgaaattg   2160

aggtcaccgt ggaaggccct aataacaaca atcctcaaac ctcagctgtt cgaaccccga   2220

cccagactaa cggttctaac gttcccttca agccacgagg gagagagttt tcctttgagg   2280

cctggaatgc caaaatcacg gacctaaaac agaaagttga aaatctcttc aatgagaaat   2340

gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc gttcgcgtta tttgagtctt   2400

tcccggaaga cttttatgtg gaaggcttac ctgagggtgt gccattccga agaccatcga   2460

cttttggcat tccgaggctg gagaagatac tcagaaacaa agccaaaatt aagttcatca   2520

ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag cacctcctct aagagccctc   2580

ccagaaaaat aaattcatca cccaatgtta atactactgc atcaggtgtt gaagacctta   2640

acatcattca ggtgacaatt ccagatgatg ataatgaaag actctcgaaa gttgaaaaag   2700

ctagacagct aagagaacaa gtgaatgacc tctttagtcg gaaatttggt gaagctattg   2760

gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac aattaaccct ggctgtgtgg   2820

tggttgatgg catgcccccg ggggtgtcct tcaaagcccc cagctacctg gaaatcagct   2880

ccatgagaag gatcttagac tctgccgagt ttatcaaatt cacggtcatt agaccatttc   2940

caggacttgt gattaataac cagctggttg atcagagtga gtcagaaggc cccgtgatac   3000

aagaatcagc tgaaccaagc cagttggaag ttccagccac agaagaaata aaagagactg   3060

atggaagctc tcagatcaag caagaaccag accccacgtg gtagacctct tccctcctag   3120

ggtaaatcag cttctgtgtc agggatgctg tgtggtgtcc atctgaaccc cctgcatacg   3180

cgtagctaat gtgatctccc cactttcaca taagatggtg gccctgcctt cagggaatgt   3240

gggagccagg tgggagcctt cccggatatt taagctagaa gattctacag ggagattctc   3300

cttggatcaa tatatgtctc tcagtcaaag atgtaaaagc acttttgcct taaaaagaat   3360

gttctgtttc taaatagagt caacgttgtc ctcctcattg gaattcacta tgagtcagaa   3420

tcattagact gacttttttt tttccatagt aatagtattt tgcagagtct cacagagctg   3480

cagatctttt gttcatcttg cagagttaac aagtctgatc ctgttagtcc agatttctta   3540

aatttggcca agttataata ggagcagtag cttgagaccc gaagtcagga aactttgaca   3600

atggattttt ttttttaatc cagagacttg tactggaatt tgccttaccc tgtcagctca   3660

tggacttaag gtttcatccc gctttatgag tgcttctgaa tccaagtcat tgttacctga   3720

atttgcaaat taagttgtga tattcgtgac tgttaaattc ctgtaattag attaacctct   3780

ttgcttgctt gtttgttttc tctcctattt tagcttaaag tatcagtggt tgagaagagc   3840

ttttcggacc tgttactacc ccaagctgtg taatatactt gtataacaga aataccttct   3900

atacaaacct ttttttctac ttttagatag aaatgtctac tttttcagca gttctgtgaa   3960

ttaaagagca gagtgactgt gggtctggaa tggctggtgt acttgggaat gtactatcag   4020

gattttacag caatgctggg aaatgacagg gaaaatgaca ggaatgaatc tcaccagatt   4080

ttttatgtac tcagcagagc cttgagttac ggtgtttatt ttccaatcaa gtgaagatat   4140

ctcctacttc tcctactgga acatctcagc ttctgcagtg aagaaaaatt cctgtgatag   4200

ttcagttctt tagtttttct atttgaaaaa aaaaaatcat ttaaatgatc ctttgttcac   4260

ggctctcctt aatgactgag tgaacagttc ctatctgtat atttgactaa accttttcct   4320

aagctatctc tcatggttcc tatgtttttt tatcataatt aaaagcaaaa ccatctggat   4380

cacctaacag tcagaggtca gtatctcagc gtgtgaatta tagaggaaat acagagagaa   4440

cctcttccac ttttactttt cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc   4500

gggttgagga ttggggctag ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt   4560

ggcgcggatt cttaggaacg ctgttctagc cggccccctc tccaggggtc gccgtggccg   4620

gcattatttc ctagttcttc ttgtaaccct gaggtgccag cgcggggagt gaggaggggt   4680

cagggggcta aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg   4740

ttgagatttc acaagcaatg cgagttgtaa aataccagct ctacaagaag ctaggctctg   4800

tgacggcata gttttcagta gctttatcac aatattcaca atggagaatt atatgacatg   4860

gtagcagaaa taggcccttt tatgtgttgc ttctatttta cctcaaattg tagatatagg   4920

gtaatcaata aaatccatcc atgcctttca cacactaagt                         4960


<210>  4213
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  4213

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu 
            420                 425                 430


Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu 
        435                 440                 445


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp 
    450                 455                 460


Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile 
465                 470                 475                 480


Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro 
                485                 490                 495


Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg 
            500                 505                 510


Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr 
        515                 520                 525


Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr 
    530                 535                 540


Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg 
545                 550                 555                 560


Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln 
                565                 570                 575


Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu 
            580                 585                 590


Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu 
        595                 600                 605


Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro 
    610                 615                 620


Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala 
625                 630                 635                 640


Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile 
                645                 650                 655


Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser 
            660                 665                 670


Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile 
        675                 680                 685


Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu 
    690                 695                 700


Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys 
705                 710                 715                 720


Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg 
                725                 730                 735


Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro 
            740                 745                 750


Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg 
        755                 760                 765


Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro 
    770                 775                 780


Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser 
785                 790                 795                 800


Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val 
                805                 810                 815


Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys 
            820                 825                 830


Gln Glu Pro Asp Pro Thr Trp 
        835


<210>  4214
<211>  7104
<212>  DNA
<213>  Homo sapiens

<400>  4214
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agctcaagct cttggactca ccgaggcagt aaaagtacca tatcctgtgt   1980

ttgaatcaaa cccggagttc ttgtatgtgg aaggcttgcc agaggggatt cccttccgaa   2040

gccctacctg gtttggaatt ccacgacttg aaaggatcgt ccgcgggagt aataaaatca   2100

agttcgttgt taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta   2160

aaataaacac taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa   2220

aggttcctga aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag   2280

ctgttcgaac cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag   2340

agttttcctt tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc   2400

tcttcaatga gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg   2460

cgttatttga gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat   2520

tccgaagacc atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca   2580

aaattaagtt catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct   2640

cctctaagag ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag   2700

gtgttgaaga ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct   2760

cgaaagttga aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat   2820

ttggtgaagc tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta   2880

accctggctg tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct   2940

acctggaaat cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg   3000

tcattaggta agtgagagtt tcctgcttag tcacaggagc gaatctggag ctcatgaggc   3060

tgactcttct aaaatgcagc cacaggtagt catcgaatcc ggcttcctat gctgtgcaat   3120

caacaaatca aaataacttg tgtcatcatt agaatgtcag atgtgcttct acgaactaag   3180

ctgactcttt taattctttg gcaaagggtt ggcaaactag gactgtttgc caaattcagg   3240

ctgcctccta tttttagagt cttcctgaaa cacagctaca cccgtattat ccatggctgc   3300

tttcctgtca cagtgagtaa gtagctggga ctgagaaggc atggcctcca aagtctaaaa   3360

tatttactct ctagcacttt gtagaaaaac cttagctagg cacagtggct aacgcctgta   3420

atcccagcat tttgggaggc caaggcaggc agatcacctg aggtcaggag ttccagacca   3480

gcctggccaa catggtgaaa tcccatctct acaaaaataa aacagttagc tgggcatgat   3540

ggcgggtgcc tgtaatccca gctactcggg aggctgaggc aggatagtcg cttgaaccca   3600

ggaggtggag gttgcaatga gccaagatca tgccactgca ctccagcctg gacgacagag   3660

tgagactcca tcacaagaaa aaaagaactt tgtcaacctc tgtcttaggg cgccttgtca   3720

caggcttcgg gtcagacgga ttcaaccttg catcagccat ttgttagcca ggtcactctg   3780

ttctttgtct gtaaatgaga ttgatcgttg ttcccactga gagtgtcagc tccttcccgt   3840

agagcaggca tgatgattgt actcacctct gacaccattg tgagtgccac attccttccc   3900

acgtccttgt cactgtaaga gatgcccacc tgagcaccaa ccccaggtta tcttcccctt   3960

tgtcttccag ccccccagaa acagctacga ctcaacctac ccaatcattt catcatcaga   4020

ttgccactgt ctctagttca ggtctcttgg gactggcact cagaaatctc ataataaatc   4080

ctcttgaggc ttctcataca ctcgtcttct tccaatcttc tttccctcaa aatctcatat   4140

tttggttcca cttcacccac cgtcattctc catatcactc ccaggagtta ggcaaaaagc   4200

cccttccgtt cttccgtatg ttaaacttag aatcactctg ttccctgctc tgcgtttcta   4260

ttttttgttt ttcctccatt tactagtagc ttaacacttt ctaacagtgt tcttattatt   4320

gatacgtatc tatctcttcc ataagcttat aaggtcacgg ataatacttc tcattgtagt   4380

acgtaaatga cgtgggctag atatgagttg aataaacagt tatacctgta aattcttaca   4440

gagtgaaaat aaattgttat actttacaat ttgtttctct ctttagacca tttccaggac   4500

ttgtgattaa taaccgtgag tattttgtga agtgttttgt ttttgttttt tcctggggtc   4560

tgacgtgtgt gcgtgtgagt gtgtatacat gcttaacgta tatcacgtta cttcacctat   4620

gtcagtaacc aggccaaata cttgttttag ccctcagtaa aaacaccagg cacttcctag   4680

ttgtaaaatt attcaagctt cttaacttcc tatcctcgat gcacttaatc ataaaatggt   4740

aataatagca ccgattttgg gggagtcgtt ccagtagatg gaaagcatct ggaacaggtg   4800

tcagcaagct cctgccgacg tgtatgcata aagttttatt gaaaccacca tcgtgtccat   4860

ttgtttatgg cagaactgag agatggcagc agcaagtgtg tgcctgcaaa acctaaaata   4920

tttactaatt ggctctgcaa gaaaagagtt tgcatccccc taacctagaa cagtgtctag   4980

cctctagtat gtgtttagcc tacagtatgt gctcagcgaa tacaatctat atttattact   5040

gcttttatga ctgttataat tactgtgctt ggatttcgtt acaaagtaag tcacaatgtg   5100

cctgcttctg ttagtatttc agcacagtgc ctggcacaca tggggctctc aaatattgct   5160

gagcgagtga acaaatgtcc tttcaattcc ttaacgttga tgtcattttc aatagtattt   5220

tgagccaaac ttaattttgc gagtgtgttt tgttttctta actttattat taaaaatgta   5280

taaaagtgag gccaggcgtg gtggctcacg cctgtaatcc cagcagtttg ggaggctgag   5340

gcaggcggat cagttgaggt tgggagttgg agaccagccc gtccaacatg gtgaaagcct   5400

gtctctacta aaaatacaaa aatcagctgg gtgtggtggc gcgtgcctgt aatcccagct   5460

actcaggagg ctgaggcagg agagttgctt gaatcctaga ggtggaggtt gcagtgagct   5520

gagatcgtgc cattgcactc cagcctgggc aacaagagca aaactctgtc ccaataaata   5580

aataaataaa atgttctctt ttgttcctgt tcttgtgcgg tagtgtggta tagagtttta   5640

tggtaattac tgtgaattag tgattctgag ggacatatca gaactctgag gtttgtttcc   5700

ttctcatctt gagggaaaca gcaaatgtat gttaaaatgc ttttccaagg gaacaacaca   5760

tccttacatt atttaaacca atctgcttca ttttcagagc tggttgatca gagtgagtca   5820

gaaggccccg tgatacaaga atcagctgaa ccaagccagt tggaagttcc agccacagaa   5880

gaaataaaag agactgatgg aagctctcag atcaagcaag aaccagaccc cacgtggtag   5940

acctcttccc tcctaggctt aaagtatcag tggttgagaa gagcttttcg gacctgttac   6000

taccccaagc tgtgtaatat acttgtataa cagaaatacc ttctatacaa accttttttt   6060

ctacttttag atagaaatgt ctactttttc agcagttctg tgaattaaag agcagagtga   6120

ctgtgggtct ggaatggctg gtgtacttgg gaatgtacta tcaggatttt acagcaatgc   6180

tgggaaatga cagggaaaat gacaggaatg aatctcacca gattttttat gtactcagca   6240

gagccttgag ttacggtgtt tattttccaa tcaagtgaag atatctccta cttctcctac   6300

tggaacatct cagcttctgc agtgaagaaa aattcctgtg atagttcagt tctttagttt   6360

ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt tcacggctct ccttaatgac   6420

tgagtgaaca gttcctatct gtatatttga ctaaaccttt tcctaagcta tctctcatgg   6480

ttcctatgtt tttttatcat aattaaaagc aaaaccatct ggatcaccta acagtcagag   6540

gtcagtatct cagcgtgtga attatagagg aaatacagag agaacctctt ccacttttac   6600

ttttcgtcca aataaaatgc atggtgtacc agaagttgaa gatcgggttg aggattgggg   6660

ctagctcgat gacactaagg ccccaacatc gcgggacctg ctgtggcgcg gattcttagg   6720

aacgctgttc tagccggccc cctctccagg ggtcgccgtg gccggcatta tttcctagtt   6780

cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg gctaaggatg   6840

caacctctga cgttctgcgc cttcctagga gagtcttaca tgtgttgaga tttcacaagc   6900

aatgcgagtt gtaaaatacc agctctacaa gaagctaggc tctgtgacgg catagttttc   6960

agtagcttta tcacaatatt cacaatggag aattatatga catggtagca gaaataggcc   7020

cttttatgtg ttgcttctat tttacctcaa attgtagata tagggtaatc aataaaatcc   7080

atccatgcct ttcacacact aagt                                          7104


<210>  4215
<211>  808
<212>  PRT
<213>  Homo sapiens

<400>  4215

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro 
    450                 455                 460


Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu 
465                 470                 475                 480


Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu 
                485                 490                 495


Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro 
            500                 505                 510


Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn 
        515                 520                 525


Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn 
    530                 535                 540


Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn 
545                 550                 555                 560


Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser 
                565                 570                 575


Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp 
            580                 585                 590


Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn 
        595                 600                 605


Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro 
    610                 615                 620


Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu 
625                 630                 635                 640


Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg 
                645                 650                 655


Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys 
            660                 665                 670


Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys 
        675                 680                 685


Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala 
    690                 695                 700


Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp 
705                 710                 715                 720


Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu 
                725                 730                 735


Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met 
            740                 745                 750


Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly 
        755                 760                 765


Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro 
    770                 775                 780


Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu 
785                 790                 795                 800


Phe Ile Lys Phe Thr Val Ile Arg 
                805


<210>  4216
<211>  5056
<212>  DNA
<213>  Homo sapiens

<400>  4216
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1980

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   2040

catatcctgt gtttgaatca aacccggagt tcttgtatgt ggaaggcttg ccagagggga   2100

ttcccttccg aagccctacc tggtttggaa ttccacgact tgaaaggatc gtccgcggga   2160

gtaataaaat caagttcgtt gttaaaaaac ctgaactagt tatttcctac ttgcctcctg   2220

ggatggctag taaaataaac actaaagctt tgcagtcccc caaaagacca cgaagtcctg   2280

ggagtaattc aaaggttcct gaaattgagg tcaccgtgga aggccctaat aacaacaatc   2340

ctcaaacctc agctgttcga accccgaccc agactaacgg ttctaacgtt cccttcaagc   2400

cacgagggag agagttttcc tttgaggcct ggaatgccaa aatcacggac ctaaaacaga   2460

aagttgaaaa tctcttcaat gagaaatgtg gggaagctct tggccttaaa caagctgtga   2520

aggtgccgtt cgcgttattt gagtctttcc cggaagactt ttatgtggaa ggcttacctg   2580

agggtgtgcc attccgaaga ccatcgactt ttggcattcc gaggctggag aagatactca   2640

gaaacaaagc caaaattaag ttcatcatta aaaagcccga aatgtttgag acggcgatta   2700

aggagagcac ctcctctaag agccctccca gaaaaataaa ttcatcaccc aatgttaata   2760

ctactgcatc aggtgttgaa gaccttaaca tcattcaggt gacaattcca gatgatgata   2820

atgaaagact ctcgaaagtt gaaaaagcta gacagctaag agaacaagtg aatgacctct   2880

ttagtcggaa atttggtgaa gctattggta tgggttttcc tgtgaaagtt ccctacagga   2940

aaatcacaat taaccctggc tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca   3000

aagcccccag ctacctggaa atcagctcca tgagaaggat cttagactct gccgagttta   3060

tcaaattcac ggtcattaga ccatttccag gacttgtgat taataaccag ctggttgatc   3120

agagtgagtc agaaggcccc gtgatacaag aatcagctga accaagccag ttggaagttc   3180

cagccacaga aggtaaaagg acctcttccc tcctagggta aatcagcttc tgtgtcaggg   3240

atgctgtgtg gtgtccatct gaaccccctg catacgcgta gctaatgtga tctccccact   3300

ttcacataag atggtggccc tgccttcagg gaatgtggga gccaggtggg agccttcccg   3360

gatatttaag ctagaagatt ctacagggag attctccttg gatcaatata tgtctctcag   3420

tcaaagatgt aaaagcactt ttgccttaaa aagaatgttc tgtttctaaa tagagtcaac   3480

gttgtcctcc tcattggaat tcactatgag tcagaatcat tagactgact tttttttttc   3540

catagtaata gtattttgca gagtctcaca gagctgcaga tcttttgttc atcttgcaga   3600

gttaacaagt ctgatcctgt tagtccagat ttcttaaatt tggccaagtt ataataggag   3660

cagtagcttg agacccgaag tcaggaaact ttgacaatgg attttttttt ttaatccaga   3720

gacttgtact ggaatttgcc ttaccctgtc agctcatgga cttaaggttt catcccgctt   3780

tatgagtgct tctgaatcca agtcattgtt acctgaattt gcaaattaag ttgtgatatt   3840

cgtgactgtt aaattcctgt aattagatta acctctttgc ttgcttgttt gttttctctc   3900

ctattttagc ttaaagtatc agtggttgag aagagctttt cggacctgtt actaccccaa   3960

gctgtgtaat atacttgtat aacagaaata ccttctatac aaaccttttt ttctactttt   4020

agatagaaat gtctactttt tcagcagttc tgtgaattaa agagcagagt gactgtgggt   4080

ctggaatggc tggtgtactt gggaatgtac tatcaggatt ttacagcaat gctgggaaat   4140

gacagggaaa atgacaggaa tgaatctcac cagatttttt atgtactcag cagagccttg   4200

agttacggtg tttattttcc aatcaagtga agatatctcc tacttctcct actggaacat   4260

ctcagcttct gcagtgaaga aaaattcctg tgatagttca gttctttagt ttttctattt   4320

gaaaaaaaaa aatcatttaa atgatccttt gttcacggct ctccttaatg actgagtgaa   4380

cagttcctat ctgtatattt gactaaacct tttcctaagc tatctctcat ggttcctatg   4440

tttttttatc ataattaaaa gcaaaaccat ctggatcacc taacagtcag aggtcagtat   4500

ctcagcgtgt gaattataga ggaaatacag agagaacctc ttccactttt acttttcgtc   4560

caaataaaat gcatggtgta ccagaagttg aagatcgggt tgaggattgg ggctagctcg   4620

atgacactaa ggccccaaca tcgcgggacc tgctgtggcg cggattctta ggaacgctgt   4680

tctagccggc cccctctcca ggggtcgccg tggccggcat tatttcctag ttcttcttgt   4740

aaccctgagg tgccagcgcg gggagtgagg aggggtcagg gggctaagga tgcaacctct   4800

gacgttctgc gccttcctag gagagtctta catgtgttga gatttcacaa gcaatgcgag   4860

ttgtaaaata ccagctctac aagaagctag gctctgtgac ggcatagttt tcagtagctt   4920

tatcacaata ttcacaatgg agaattatat gacatggtag cagaaatagg cccttttatg   4980

tgttgcttct attttacctc aaattgtaga tatagggtaa tcaataaaat ccatccatgc   5040

ctttcacaca ctaagt                                                   5056


<210>  4217
<211>  878
<212>  PRT
<213>  Homo sapiens

<400>  4217

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
    450                 455                 460


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
465                 470                 475                 480


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
                485                 490                 495


Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr 
            500                 505                 510


Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys 
        515                 520                 525


Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro 
    530                 535                 540


Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys 
545                 550                 555                 560


Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val 
                565                 570                 575


Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg 
            580                 585                 590


Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly 
        595                 600                 605


Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys 
    610                 615                 620


Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly 
625                 630                 635                 640


Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro 
                645                 650                 655


Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg 
            660                 665                 670


Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys 
        675                 680                 685


Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala 
    690                 695                 700


Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser 
705                 710                 715                 720


Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile 
                725                 730                 735


Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val 
            740                 745                 750


Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg 
        755                 760                 765


Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr 
    770                 775                 780


Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro 
785                 790                 795                 800


Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met 
                805                 810                 815


Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
            820                 825                 830


Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu 
        835                 840                 845


Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu 
    850                 855                 860


Val Pro Ala Thr Glu Gly Lys Arg Thr Ser Ser Leu Leu Gly 
865                 870                 875


<210>  4218
<211>  4351
<212>  DNA
<213>  Homo sapiens

<400>  4218
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040

taccatatcc tgtgtttgaa tcaaacccgg agttcttgaa aggatcgtcc gcgggagtaa   2100

taaaatcaag ttcgttgtta aaaaacctga actagttatt tcctacttgc ctcctgggat   2160

ggctagtaaa ataaacacta aagctttgca gtcccccaaa agaccacgaa gtcctgggag   2220

taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc cctaataaca acaatcctca   2280

aacctcagct gttcgaaccc cgacccagac taacggttct aacgttccct tcaagccacg   2340

agggagagag ttttcctttg aggcctggaa tgccaaaatc acggacctaa aacagaaagt   2400

tgaaaatctc ttcaatgaga aatgtgggga agctcttggc cttaaacaag ctgtgaaggt   2460

gccgttcgcg ttatttgagt ctttcccgga agacttttat gtggaaggct tacctgaggg   2520

tgtgccattc cgaagaccat cgacttttgg cattccgagg ctggagaaga tactcagaaa   2580

caaagccaaa attaagttca tcattaaaaa gcccgaaatg tttgagacgg cgattaagga   2640

gagcacctcc tctaagagcc ctcccagaaa aataaattca tcacccaatg ttaatactac   2700

tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca attccagatg atgataatga   2760

aagactctcg aaagttgaaa aagctagaca gctaagagaa caagtgaatg acctctttag   2820

tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg aaagttccct acaggaaaat   2880

cacaattaac cctggctgtg tggtggttga tggcatgccc ccgggggtgt ccttcaaagc   2940

ccccagctac ctggaaatca gctccatgag aaggatctta gactctgccg agtttatcaa   3000

attcacggtc attagaccat ttccaggact tgtgattaat aaccagctgg ttgatcagag   3060

tgagtcagaa ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc   3120

cacagaagaa ataaaagaga ctgatggaag ctctcagatc aagcaagaac cagaccccac   3180

gtggtagacc tcttccctcc taggcttaaa gtatcagtgg ttgagaagag cttttcggac   3240

ctgttactac cccaagctgt gtaatatact tgtataacag aaataccttc tatacaaacc   3300

tttttttcta cttttagata gaaatgtcta ctttttcagc agttctgtga attaaagagc   3360

agagtgactg tgggtctgga atggctggtg tacttgggaa tgtactatca ggattttaca   3420

gcaatgctgg gaaatgacag ggaaaatgac aggaatgaat ctcaccagat tttttatgta   3480

ctcagcagag ccttgagtta cggtgtttat tttccaatca agtgaagata tctcctactt   3540

ctcctactgg aacatctcag cttctgcagt gaagaaaaat tcctgtgata gttcagttct   3600

ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat cctttgttca cggctctcct   3660

taatgactga gtgaacagtt cctatctgta tatttgacta aaccttttcc taagctatct   3720

ctcatggttc ctatgttttt ttatcataat taaaagcaaa accatctgga tcacctaaca   3780

gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa tacagagaga acctcttcca   3840

cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga agttgaagat cgggttgagg   3900

attggggcta gctcgatgac actaaggccc caacatcgcg ggacctgctg tggcgcggat   3960

tcttaggaac gctgttctag ccggccccct ctccaggggt cgccgtggcc ggcattattt   4020

cctagttctt cttgtaaccc tgaggtgcca gcgcggggag tgaggagggg tcagggggct   4080

aaggatgcaa cctctgacgt tctgcgcctt cctaggagag tcttacatgt gttgagattt   4140

cacaagcaat gcgagttgta aaataccagc tctacaagaa gctaggctct gtgacggcat   4200

agttttcagt agctttatca caatattcac aatggagaat tatatgacat ggtagcagaa   4260

ataggccctt ttatgtgttg cttctatttt acctcaaatt gtagatatag ggtaatcaat   4320

aaaatccatc catgcctttc acacactaag t                                  4351


<210>  4219
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  4219

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
    450                 455                 460


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
465                 470                 475                 480


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
                485                 490                 495


Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu 
            500                 505                 510


Lys Asn Leu Asn 
        515


<210>  4220
<211>  3903
<212>  DNA
<213>  Homo sapiens

<400>  4220
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2040

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2100

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2160

tgaatcaaac ccggagttct tgaaaggatc gtccgcggga gtaataaaat caagttcgtt   2220

gttaaaaaac ctgaactagt tatttcctac ttgcctcctg ggatggctag taaaataaac   2280

actaaagctt tgcagtcccc caaaagacca cgaagtcctg ggagtaattc aaaggttcct   2340

gaaattgagg tcaccgtgga aggccctaat aacaacaatc ctcaaacctc agctgttcga   2400

accccgaccc agactaacgg ttctaacgtt cccttcaagc cacgagggag agagttttcc   2460

tttgaggcct ggaatgccaa aatcacggac ctaaaacaga aagttgaaaa tctcttcaat   2520

gagaaatgtg gggaagctct tggccttaaa caagctgtga aggtgccgtt cgcgttattt   2580

gagtctttcc cggaagactt ttatgtggaa ggcttacctg agggtgtgcc attccgaaga   2640

ccatcgactt ttggcattcc gaggctggag aagatactca gaaacaaagc caaaattaag   2700

ttcatcatta aaaagcccga aatgtttgag acggcgatta aggagagcac ctcctctaag   2760

agccctccca gaaaaataaa ttcatcaccc aatgttaata ctactgcatc aggtgttgaa   2820

gaccttaaca tcattcaggt gacaattcca gatgatgata atgaaagact ctcgaaagtt   2880

gaaaaagcta gacagctaag agaacaagtg aatgacctct ttagtcggaa atttggtgaa   2940

gctattggta tgggttttcc tgtgaaagtt ccctacagga aaatcacaat taaccctggc   3000

tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca aagcccccag ctacctggaa   3060

atcagctcca tgagaaggat cttagactct gccgagttta tcaaattcac ggtcattaga   3120

ccatttccag gacttgtgat taataaccag ctggttgatc agagtgagtc agaaggcccc   3180

gtgatacaag aatcagctga accaagccag ttggaagttc cagccacaga agaaataaaa   3240

gagactgatg gaagctctca gatcaagcaa gaaccagacc ccacgtggta gacctcttcc   3300

ctcctaggca aaaccatctg gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa   3360

ttatagagga aatacagaga gaacctcttc cacttttact tttcgtccaa ataaaatgca   3420

tggtgtacca gaagttgaag atcgggttga ggattggggc tagctcgatg acactaaggc   3480

cccaacatcg cgggacctgc tgtggcgcgg attcttagga acgctgttct agccggcccc   3540

ctctccaggg gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac cctgaggtgc   3600

cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc   3660

ttcctaggag agtcttacat gtgttgagat ttcacaagca atgcgagttg taaaatacca   3720

gctctacaag aagctaggct ctgtgacggc atagttttca gtagctttat cacaatattc   3780

acaatggaga attatatgac atggtagcag aaataggccc ttttatgtgt tgcttctatt   3840

ttacctcaaa ttgtagatat agggtaatca ataaaatcca tccatgcctt tcacacacta   3900

agt                                                                 3903


<210>  4221
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  4221

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala 
            580                 585                 590


Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600                 605


<210>  4222
<211>  4163
<212>  DNA
<213>  Homo sapiens

<400>  4222
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagctca   2040

agctcttgga ctcaccgagg cagtaaaagt accatatcct gtgtttgaat caaacccgga   2100

gttcttgtat gtggaaggct tgccagaggg gattcccttc cgaagcccta cctggtttgg   2160

aattccacga cttgaaagga tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa   2220

acctgaacta gttatttcct acttgcctcc tgggatggct agtaaaataa acactaaagc   2280

tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga   2340

ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc tcagctgttc gaaccccgac   2400

ccagactaac ggttctaacg ttcccttcaa gccacgaggg agagagtttt cctttgaggc   2460

ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa aatctcttca atgagaaatg   2520

tggggaagct cttggcctta aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt   2580

cccggaagac ttttatgtgg aaggcttacc tgagggtgtg ccattccgaa gaccatcgac   2640

ttttggcatt ccgaggctgg agaagatact cagaaacaaa gccaaaatta agttcatcat   2700

taaaaagccc gaaatgtttg agacggcgat taaggagagc acctcctcta agagccctcc   2760

cagaaaaata aattcatcac ccaatgttaa tactactgca tcaggtgttg aagaccttaa   2820

catcattcag gtgacaattc cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc   2880

tagacagcta agagaacaag tgaatgacct ctttagtcgg aaatttggtg aagctattgg   2940

tatgggtttt cctgtgaaag ttccctacag gaaaatcaca attaaccctg gctgtgtggt   3000

ggttgatggc atgcccccgg gggtgtcctt caaagccccc agctacctgg aaatcagctc   3060

catgagaagg atcttagact ctgccgagtt tatcaaattc acggtcatta gaccatttcc   3120

aggacttgtg attaataacc agctggttga tcagagtgag tcagaaggcc ccgtgataca   3180

agaatcagct gaaccaagcc agttggaagt tccagccaca gaagaaataa aagagactga   3240

tggaagctct cagatcaagc aagaaccaga ccccacgtgg tagacctctt ccctcctagg   3300

agccttgagt tacggtgttt attttccaat caagtgaaga tatctcctac ttctcctact   3360

ggaacatctc agcttctgca gtgaagaaaa attcctgtga tagttcagtt ctttagtttt   3420

tctatttgaa aaaaaaaaat catttaaatg atcctttgtt cacggctctc cttaatgact   3480

gagtgaacag ttcctatctg tatatttgac taaacctttt cctaagctat ctctcatggt   3540

tcctatgttt ttttatcata attaaaagca aaaccatctg gatcacctaa cagtcagagg   3600

tcagtatctc agcgtgtgaa ttatagagga aatacagaga gaacctcttc cacttttact   3660

tttcgtccaa ataaaatgca tggtgtacca gaagttgaag atcgggttga ggattggggc   3720

tagctcgatg acactaaggc cccaacatcg cgggacctgc tgtggcgcgg attcttagga   3780

acgctgttct agccggcccc ctctccaggg gtcgccgtgg ccggcattat ttcctagttc   3840

ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc   3900

aacctctgac gttctgcgcc ttcctaggag agtcttacat gtgttgagat ttcacaagca   3960

atgcgagttg taaaatacca gctctacaag aagctaggct ctgtgacggc atagttttca   4020

gtagctttat cacaatattc acaatggaga attatatgac atggtagcag aaataggccc   4080

ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat agggtaatca ataaaatcca   4140

tccatgcctt tcacacacta agt                                           4163


<210>  4223
<211>  953
<212>  PRT
<213>  Homo sapiens

<400>  4223

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu 
    530                 535                 540


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
545                 550                 555                 560


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
                565                 570                 575


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
            580                 585                 590


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
        595                 600                 605


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
    610                 615                 620


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
625                 630                 635                 640


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
                645                 650                 655


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
            660                 665                 670


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
        675                 680                 685


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
    690                 695                 700


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
705                 710                 715                 720


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
                725                 730                 735


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
            740                 745                 750


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
        755                 760                 765


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
    770                 775                 780


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
785                 790                 795                 800


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
                805                 810                 815


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
            820                 825                 830


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
        835                 840                 845


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
    850                 855                 860


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
865                 870                 875                 880


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
                885                 890                 895


Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser 
            900                 905                 910


Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu 
        915                 920                 925


Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln 
    930                 935                 940


Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  4224
<211>  4992
<212>  DNA
<213>  Homo sapiens

<400>  4224
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040

taccatatcc tgtgtttgaa tcaaacccgg agttcttgaa aggatcgtcc gcgggagtaa   2100

taaaatcaag ttcgttgtta aaaaacctga actagttatt tcctacttgc ctcctgggat   2160

ggctagtaaa ataaacacta aagctttgca gtcccccaaa agaccacgaa gtcctgggag   2220

taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc cctaataaca acaatcctca   2280

aacctcagct gttcgaaccc cgacccagac taacggttct aacgttccct tcaagccacg   2340

agggagagag ttttcctttg aggcctggaa tgccaaaatc acggacctaa aacagaaagt   2400

tgaaaatctc ttcaatgaga aatgtgggga agctcttggc cttaaacaag ctgtgaaggt   2460

gccgttcgcg ttatttgagt ctttcccgga agacttttat gtggaaggct tacctgaggg   2520

tgtgccattc cgaagaccat cgacttttgg cattccgagg ctggagaaga tactcagaaa   2580

caaagccaaa attaagttca tcattaaaaa gcccgaaatg tttgagacgg cgattaagga   2640

gagcacctcc tctaagagcc ctcccagaaa aataaattca tcacccaatg ttaatactac   2700

tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca attccagatg atgataatga   2760

aagactctcg aaagttgaaa aagctagaca gctaagagaa caagtgaatg acctctttag   2820

tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg aaagttccct acaggaaaat   2880

cacaattaac cctggctgtg tggtggttga tggcatgccc ccgggggtgt ccttcaaagc   2940

ccccagctac ctggaaatca gctccatgag aaggatctta gactctgccg agtttatcaa   3000

attcacggtc attagaccat ttccaggact tgtgattaat aaccagctgg ttgatcagag   3060

tgagtcagaa ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc   3120

cacagaaggt aaaaggacct cttccctcct agggtaaatc agcttctgtg tcagggatgc   3180

tgtgtggtgt ccatctgaac cccctgcata cgcgtagcta atgtgatctc cccactttca   3240

cataagatgg tggccctgcc ttcagggaat gtgggagcca ggtgggagcc ttcccggata   3300

tttaagctag aagattctac agggagattc tccttggatc aatatatgtc tctcagtcaa   3360

agatgtaaaa gcacttttgc cttaaaaaga atgttctgtt tctaaataga gtcaacgttg   3420

tcctcctcat tggaattcac tatgagtcag aatcattaga ctgacttttt tttttccata   3480

gtaatagtat tttgcagagt ctcacagagc tgcagatctt ttgttcatct tgcagagtta   3540

acaagtctga tcctgttagt ccagatttct taaatttggc caagttataa taggagcagt   3600

agcttgagac ccgaagtcag gaaactttga caatggattt ttttttttaa tccagagact   3660

tgtactggaa tttgccttac cctgtcagct catggactta aggtttcatc ccgctttatg   3720

agtgcttctg aatccaagtc attgttacct gaatttgcaa attaagttgt gatattcgtg   3780

actgttaaat tcctgtaatt agattaacct ctttgcttgc ttgtttgttt tctctcctat   3840

tttagcttaa agtatcagtg gttgagaaga gcttttcgga cctgttacta ccccaagctg   3900

tgtaatatac ttgtataaca gaaatacctt ctatacaaac ctttttttct acttttagat   3960

agaaatgtct actttttcag cagttctgtg aattaaagag cagagtgact gtgggtctgg   4020

aatggctggt gtacttggga atgtactatc aggattttac agcaatgctg ggaaatgaca   4080

gggaaaatga caggaatgaa tctcaccaga ttttttatgt actcagcaga gccttgagtt   4140

acggtgttta ttttccaatc aagtgaagat atctcctact tctcctactg gaacatctca   4200

gcttctgcag tgaagaaaaa ttcctgtgat agttcagttc tttagttttt ctatttgaaa   4260

aaaaaaaatc atttaaatga tcctttgttc acggctctcc ttaatgactg agtgaacagt   4320

tcctatctgt atatttgact aaaccttttc ctaagctatc tctcatggtt cctatgtttt   4380

tttatcataa ttaaaagcaa aaccatctgg atcacctaac agtcagaggt cagtatctca   4440

gcgtgtgaat tatagaggaa atacagagag aacctcttcc acttttactt ttcgtccaaa   4500

taaaatgcat ggtgtaccag aagttgaaga tcgggttgag gattggggct agctcgatga   4560

cactaaggcc ccaacatcgc gggacctgct gtggcgcgga ttcttaggaa cgctgttcta   4620

gccggccccc tctccagggg tcgccgtggc cggcattatt tcctagttct tcttgtaacc   4680

ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc taaggatgca acctctgacg   4740

ttctgcgcct tcctaggaga gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt   4800

aaaataccag ctctacaaga agctaggctc tgtgacggca tagttttcag tagctttatc   4860

acaatattca caatggagaa ttatatgaca tggtagcaga aataggccct tttatgtgtt   4920

gcttctattt tacctcaaat tgtagatata gggtaatcaa taaaatccat ccatgccttt   4980

cacacactaa gt                                                       4992


<210>  4225
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  4225

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
    450                 455                 460


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
465                 470                 475                 480


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
                485                 490                 495


Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu 
            500                 505                 510


Lys Asn Leu Asn 
        515


<210>  4226
<211>  4984
<212>  DNA
<213>  Homo sapiens

<400>  4226
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gctcaagctc ttggactcac cgaggcagta aaagtaccat   1920

atcctgtgtt tgaatcaaac ccggagttct tgtatgtgga aggcttgcca gaggggattc   1980

ccttccgaag ccctacctgg tttggaattc cacgacttga aaggatcgtc cgcgggagta   2040

ataaaatcaa gttcgttgtt aaaaaacctg aactagttat ttcctacttg cctcctggga   2100

tggctagtaa aataaacact aaagctttgc agtcccccaa aagaccacga agtcctggga   2160

gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg ccctaataac aacaatcctc   2220

aaacctcagc tgttcgaacc ccgacccaga ctaacggttc taacgttccc ttcaagccac   2280

gagggagaga gttttccttt gaggcctgga atgccaaaat cacggaccta aaacagaaag   2340

ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg   2400

tgccgttcgc gttatttgag tctttcccgg aagactttta tgtggaaggc ttacctgagg   2460

gtgtgccatt ccgaagacca tcgacttttg gcattccgag gctggagaag atactcagaa   2520

acaaagccaa aattaagttc atcattaaaa agcccgaaat gtttgagacg gcgattaagg   2580

agagcacctc ctctaagagc cctcccagaa aaataaattc atcacccaat gttaatacta   2640

ctgcatcagg tgttgaagac cttaacatca ttcaggtgac aattccagat gatgataatg   2700

aaagactctc gaaagttgaa aaagctagac agctaagaga acaagtgaat gacctcttta   2760

gtcggaaatt tggtgaagct attggtatgg gttttcctgt gaaagttccc tacaggaaaa   2820

tcacaattaa ccctggctgt gtggtggttg atggcatgcc cccgggggtg tccttcaaag   2880

cccccagcta cctggaaatc agctccatga gaaggatctt agactctgcc gagtttatca   2940

aattcacggt cattagacca tttccaggac ttgtgattaa taaccagctg gttgatcaga   3000

gtgagtcaga aggccccgtg atacaagaat cagctgaacc aagccagttg gaagttccag   3060

ccacagaaga aataaaagag actgatggaa gctctcagat caagcaagaa ccagacccca   3120

cgtggtagac ctcttccctc ctagggtaaa tcagcttctg tgtcagggat gctgtgtggt   3180

gtccatctga accccctgca tacgcgtagc taatgtgatc tccccacttt cacataagat   3240

ggtggccctg ccttcaggga atgtgggagc caggtgggag ccttcccgga tatttaagct   3300

agaagattct acagggagat tctccttgga tcaatatatg tctctcagtc aaagatgtaa   3360

aagcactttt gccttaaaaa gaatgttctg tttctaaata gagtcaacgt tgtcctcctc   3420

attggaattc actatgagtc agaatcatta gactgacttt tttttttcca tagtaatagt   3480

attttgcaga gtctcacaga gctgcagatc ttttgttcat cttgcagagt taacaagtct   3540

gatcctgtta gtccagattt cttaaatttg gccaagttat aataggagca gtagcttgag   3600

acccgaagtc aggaaacttt gacaatggat tttttttttt aatccagaga cttgtactgg   3660

aatttgcctt accctgtcag ctcatggact taaggtttca tcccgcttta tgagtgcttc   3720

tgaatccaag tcattgttac ctgaatttgc aaattaagtt gtgatattcg tgactgttaa   3780

attcctgtaa ttagattaac ctctttgctt gcttgtttgt tttctctcct attttagctt   3840

aaagtatcag tggttgagaa gagcttttcg gacctgttac taccccaagc tgtgtaatat   3900

acttgtataa cagaaatacc ttctatacaa accttttttt ctacttttag atagaaatgt   3960

ctactttttc agcagttctg tgaattaaag agcagagtga ctgtgggtct ggaatggctg   4020

gtgtacttgg gaatgtacta tcaggatttt acagcaatgc tgggaaatga cagggaaaat   4080

gacaggaatg aatctcacca gattttttat gtactcagca gagccttgag ttacggtgtt   4140

tattttccaa tcaagtgaag atatctccta cttctcctac tggaacatct cagcttctgc   4200

agtgaagaaa aattcctgtg atagttcagt tctttagttt ttctatttga aaaaaaaaaa   4260

tcatttaaat gatcctttgt tcacggctct ccttaatgac tgagtgaaca gttcctatct   4320

gtatatttga ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt tttttatcat   4380

aattaaaagc aaaaccatct ggatcaccta acagtcagag gtcagtatct cagcgtgtga   4440

attatagagg aaatacagag agaacctctt ccacttttac ttttcgtcca aataaaatgc   4500

atggtgtacc agaagttgaa gatcgggttg aggattgggg ctagctcgat gacactaagg   4560

ccccaacatc gcgggacctg ctgtggcgcg gattcttagg aacgctgttc tagccggccc   4620

cctctccagg ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa ccctgaggtg   4680

ccagcgcggg gagtgaggag gggtcagggg gctaaggatg caacctctga cgttctgcgc   4740

cttcctagga gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc   4800

agctctacaa gaagctaggc tctgtgacgg catagttttc agtagcttta tcacaatatt   4860

cacaatggag aattatatga catggtagca gaaataggcc cttttatgtg ttgcttctat   4920

tttacctcaa attgtagata tagggtaatc aataaaatcc atccatgcct ttcacacact   4980

aagt                                                                4984


<210>  4227
<211>  908
<212>  PRT
<213>  Homo sapiens

<400>  4227

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala 
                485                 490                 495


Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser 
            500                 505                 510


Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        515                 520                 525


Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg 
    530                 535                 540


Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile 
545                 550                 555                 560


Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu 
                565                 570                 575


Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro 
            580                 585                 590


Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr 
        595                 600                 605


Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe 
    610                 615                 620


Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile 
625                 630                 635                 640


Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly 
                645                 650                 655


Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe 
            660                 665                 670


Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val 
        675                 680                 685


Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile 
    690                 695                 700


Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met 
705                 710                 715                 720


Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg 
                725                 730                 735


Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu 
            740                 745                 750


Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg 
        755                 760                 765


Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp 
    770                 775                 780


Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val 
785                 790                 795                 800


Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val 
                805                 810                 815


Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu 
            820                 825                 830


Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe 
        835                 840                 845


Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val 
    850                 855                 860


Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro 
865                 870                 875                 880


Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly 
                885                 890                 895


Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
            900                 905


<210>  4228
<211>  5160
<212>  DNA
<213>  Homo sapiens

<400>  4228
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   2040

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2100

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2160

atcaaacccg gagttcttgt atgtggaagg cttgccagag gggattccct tccgaagccc   2220

tacctggttt ggaattccac gacttgaaag gatcgtccgc gggagtaata aaatcaagtt   2280

cgttgttaaa aaacctgaac tagttatttc ctacttgcct cctgggatgg ctagtaaaat   2340

aaacactaaa gctttgcagt cccccaaaag accacgaagt cctgggagta attcaaaggt   2400

tcctgaaatt gaggtcaccg tggaaggccc taataacaac aatcctcaaa cctcagctgt   2460

tcgaaccccg acccagacta acggttctaa cgttcccttc aagccacgag ggagagagtt   2520

ttcctttgag gcctggaatg ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt   2580

caatgagaaa tgtggggaag ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt   2640

atttgagtct ttcccggaag acttttatgt ggaaggctta cctgagggtg tgccattccg   2700

aagaccatcg acttttggca ttccgaggct ggagaagata ctcagaaaca aagccaaaat   2760

taagttcatc attaaaaagc ccgaaatgtt tgagacggcg attaaggaga gcacctcctc   2820

taagagccct cccagaaaaa taaattcatc acccaatgtt aatactactg catcaggtgt   2880

tgaagacctt aacatcattc aggtgacaat tccagatgat gataatgaaa gactctcgaa   2940

agttgaaaaa gctagacagc taagagaaca agtgaatgac ctctttagtc ggaaatttgg   3000

tgaagctatt ggtatgggtt ttcctgtgaa agttccctac aggaaaatca caattaaccc   3060

tggctgtgtg gtggttgatg gcatgccccc gggggtgtcc ttcaaagccc ccagctacct   3120

ggaaatcagc tccatgagaa ggatcttaga ctctgccgag tttatcaaat tcacggtcat   3180

tagaccattt ccaggacttg tgattaataa ccagctggtt gatcagagtg agtcagaagg   3240

ccccgtgata caagaatcag ctgaaccaag ccagttggaa gttccagcca cagaaggtaa   3300

aaggacctct tccctcctag ggtaaatcag cttctgtgtc agggatgctg tgtggtgtcc   3360

atctgaaccc cctgcatacg cgtagctaat gtgatctccc cactttcaca taagatggtg   3420

gccctgcctt cagggaatgt gggagccagg tgggagcctt cccggatatt taagctagaa   3480

gattctacag ggagattctc cttggatcaa tatatgtctc tcagtcaaag atgtaaaagc   3540

acttttgcct taaaaagaat gttctgtttc taaatagagt caacgttgtc ctcctcattg   3600

gaattcacta tgagtcagaa tcattagact gacttttttt tttccatagt aatagtattt   3660

tgcagagtct cacagagctg cagatctttt gttcatcttg cagagttaac aagtctgatc   3720

ctgttagtcc agatttctta aatttggcca agttataata ggagcagtag cttgagaccc   3780

gaagtcagga aactttgaca atggattttt ttttttaatc cagagacttg tactggaatt   3840

tgccttaccc tgtcagctca tggacttaag gtttcatccc gctttatgag tgcttctgaa   3900

tccaagtcat tgttacctga atttgcaaat taagttgtga tattcgtgac tgttaaattc   3960

ctgtaattag attaacctct ttgcttgctt gtttgttttc tctcctattt tagcttaaag   4020

tatcagtggt tgagaagagc ttttcggacc tgttactacc ccaagctgtg taatatactt   4080

gtataacaga aataccttct atacaaacct ttttttctac ttttagatag aaatgtctac   4140

tttttcagca gttctgtgaa ttaaagagca gagtgactgt gggtctggaa tggctggtgt   4200

acttgggaat gtactatcag gattttacag caatgctggg aaatgacagg gaaaatgaca   4260

ggaatgaatc tcaccagatt ttttatgtac tcagcagagc cttgagttac ggtgtttatt   4320

ttccaatcaa gtgaagatat ctcctacttc tcctactgga acatctcagc ttctgcagtg   4380

aagaaaaatt cctgtgatag ttcagttctt tagtttttct atttgaaaaa aaaaaatcat   4440

ttaaatgatc ctttgttcac ggctctcctt aatgactgag tgaacagttc ctatctgtat   4500

atttgactaa accttttcct aagctatctc tcatggttcc tatgtttttt tatcataatt   4560

aaaagcaaaa ccatctggat cacctaacag tcagaggtca gtatctcagc gtgtgaatta   4620

tagaggaaat acagagagaa cctcttccac ttttactttt cgtccaaata aaatgcatgg   4680

tgtaccagaa gttgaagatc gggttgagga ttggggctag ctcgatgaca ctaaggcccc   4740

aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg ctgttctagc cggccccctc   4800

tccaggggtc gccgtggccg gcattatttc ctagttcttc ttgtaaccct gaggtgccag   4860

cgcggggagt gaggaggggt cagggggcta aggatgcaac ctctgacgtt ctgcgccttc   4920

ctaggagagt cttacatgtg ttgagatttc acaagcaatg cgagttgtaa aataccagct   4980

ctacaagaag ctaggctctg tgacggcata gttttcagta gctttatcac aatattcaca   5040

atggagaatt atatgacatg gtagcagaaa taggcccttt tatgtgttgc ttctatttta   5100

cctcaaattg tagatatagg gtaatcaata aaatccatcc atgcctttca cacactaagt   5160


<210>  4229
<211>  967
<212>  PRT
<213>  Homo sapiens

<400>  4229

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
                565                 570                 575


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
            580                 585                 590


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
        595                 600                 605


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
    610                 615                 620


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
625                 630                 635                 640


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
                645                 650                 655


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
            660                 665                 670


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
        675                 680                 685


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
    690                 695                 700


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
705                 710                 715                 720


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
                725                 730                 735


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
            740                 745                 750


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
        755                 760                 765


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
    770                 775                 780


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
785                 790                 795                 800


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
                805                 810                 815


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
            820                 825                 830


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
        835                 840                 845


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
    850                 855                 860


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
865                 870                 875                 880


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
                885                 890                 895


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
            900                 905                 910


Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile 
        915                 920                 925


Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln 
    930                 935                 940


Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Gly Lys 
945                 950                 955                 960


Arg Thr Ser Ser Leu Leu Gly 
                965


<210>  4230
<211>  5132
<212>  DNA
<213>  Homo sapiens

<400>  4230
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1920

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct tagatttgtt   1980

gacagcggtt tcctggagtg ctgtcttgag aacgattctg aggaggctca gcaagaaaga   2040

gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa ctcaagctct tggactcacc   2100

gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc cggagttctt gtatgtggaa   2160

ggcttgccag aggggattcc cttccgaagc cctacctggt ttggaattcc acgacttgaa   2220

aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta aaaaacctga actagttatt   2280

tcctacttgc ctcctgggat ggctagtaaa ataaacacta aagctttgca gtcccccaaa   2340

agaccacgaa gtcctgggag taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc   2400

cctaataaca acaatcctca aacctcagct gttcgaaccc cgacccagac taacggttct   2460

aacgttccct tcaagccacg agggagagag ttttcctttg aggcctggaa tgccaaaatc   2520

acggacctaa aacagaaagt tgaaaatctc ttcaatgaga aatgtgggga agctcttggc   2580

cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt ctttcccgga agacttttat   2640

gtggaaggct tacctgaggg tgtgccattc cgaagaccat cgacttttgg cattccgagg   2700

ctggagaaga tactcagaaa caaagccaaa attaagttca tcattaaaaa gcccgaaatg   2760

tttgagacgg cgattaagga gagcacctcc tctaagagcc ctcccagaaa aataaattca   2820

tcacccaatg ttaatactac tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca   2880

attccagatg atgataatga aagactctcg aaagttgaaa aagctagaca gctaagagaa   2940

caagtgaatg acctctttag tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg   3000

aaagttccct acaggaaaat cacaattaac cctggctgtg tggtggttga tggcatgccc   3060

ccgggggtgt ccttcaaagc ccccagctac ctggaaatca gctccatgag aaggatctta   3120

gactctgccg agtttatcaa attcacggtc attagaccat ttccaggact tgtgattaat   3180

aaccagctgg ttgatcagag tgagtcagaa ggccccgtga tacaagaatc agctgaacca   3240

agccagttgg aagttccagc cacagaaggt aaaaggacct cttccctcct agggtaaatc   3300

agcttctgtg tcagggatgc tgtgtggtgt ccatctgaac cccctgcata cgcgtagcta   3360

atgtgatctc cccactttca cataagatgg tggccctgcc ttcagggaat gtgggagcca   3420

ggtgggagcc ttcccggata tttaagctag aagattctac agggagattc tccttggatc   3480

aatatatgtc tctcagtcaa agatgtaaaa gcacttttgc cttaaaaaga atgttctgtt   3540

tctaaataga gtcaacgttg tcctcctcat tggaattcac tatgagtcag aatcattaga   3600

ctgacttttt tttttccata gtaatagtat tttgcagagt ctcacagagc tgcagatctt   3660

ttgttcatct tgcagagtta acaagtctga tcctgttagt ccagatttct taaatttggc   3720

caagttataa taggagcagt agcttgagac ccgaagtcag gaaactttga caatggattt   3780

ttttttttaa tccagagact tgtactggaa tttgccttac cctgtcagct catggactta   3840

aggtttcatc ccgctttatg agtgcttctg aatccaagtc attgttacct gaatttgcaa   3900

attaagttgt gatattcgtg actgttaaat tcctgtaatt agattaacct ctttgcttgc   3960

ttgtttgttt tctctcctat tttagcttaa agtatcagtg gttgagaaga gcttttcgga   4020

cctgttacta ccccaagctg tgtaatatac ttgtataaca gaaatacctt ctatacaaac   4080

ctttttttct acttttagat agaaatgtct actttttcag cagttctgtg aattaaagag   4140

cagagtgact gtgggtctgg aatggctggt gtacttggga atgtactatc aggattttac   4200

agcaatgctg ggaaatgaca gggaaaatga caggaatgaa tctcaccaga ttttttatgt   4260

actcagcaga gccttgagtt acggtgttta ttttccaatc aagtgaagat atctcctact   4320

tctcctactg gaacatctca gcttctgcag tgaagaaaaa ttcctgtgat agttcagttc   4380

tttagttttt ctatttgaaa aaaaaaaatc atttaaatga tcctttgttc acggctctcc   4440

ttaatgactg agtgaacagt tcctatctgt atatttgact aaaccttttc ctaagctatc   4500

tctcatggtt cctatgtttt tttatcataa ttaaaagcaa aaccatctgg atcacctaac   4560

agtcagaggt cagtatctca gcgtgtgaat tatagaggaa atacagagag aacctcttcc   4620

acttttactt ttcgtccaaa taaaatgcat ggtgtaccag aagttgaaga tcgggttgag   4680

gattggggct agctcgatga cactaaggcc ccaacatcgc gggacctgct gtggcgcgga   4740

ttcttaggaa cgctgttcta gccggccccc tctccagggg tcgccgtggc cggcattatt   4800

tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc   4860

taaggatgca acctctgacg ttctgcgcct tcctaggaga gtcttacatg tgttgagatt   4920

tcacaagcaa tgcgagttgt aaaataccag ctctacaaga agctaggctc tgtgacggca   4980

tagttttcag tagctttatc acaatattca caatggagaa ttatatgaca tggtagcaga   5040

aataggccct tttatgtgtt gcttctattt tacctcaaat tgtagatata gggtaatcaa   5100

taaaatccat ccatgccttt cacacactaa gt                                 5132


<210>  4231
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  4231

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
            500                 505                 510


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
        515                 520


<210>  4232
<211>  4614
<212>  DNA
<213>  Homo sapiens

<400>  4232
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   2040

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gcttagattt   2100

gttgacagcg gtttcctgga gtgctgtctt gagaacgatt ctgaggaggc tcagcaagaa   2160

agagtgtttc agttgattgg gtgtgtctgt catggagaag gaactcaagc tcttggactc   2220

accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgtatgtg   2280

gaaggcttgc cagaggggat tcccttccga agccctacct ggtttggaat tccacgactt   2340

gaaaggatcg tccgcgggag taataaaatc aagttcgttg ttaaaaaacc tgaactagtt   2400

atttcctact tgcctcctgg gatggctagt aaaataaaca ctaaagcttt gcagtccccc   2460

aaaagaccac gaagtcctgg gagtaattca aaggttcctg aaattgaggt caccgtggaa   2520

ggccctaata acaacaatcc tcaaacctca gctgttcgaa ccccgaccca gactaacggt   2580

tctaacgttc ccttcaagcc acgagggaga gagttttcct ttgaggcctg gaatgccaaa   2640

atcacggacc taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg ggaagctctt   2700

ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg agtctttccc ggaagacttt   2760

tatgtggaag gcttacctga gggtgtgcca ttccgaagac catcgacttt tggcattccg   2820

aggctggaga agatactcag aaacaaagcc aaaattaagt tcatcattaa aaagcccgaa   2880

atgtttgaga cggcgattaa ggagagcacc tcctctaaga gccctcccag aaaaataaat   2940

tcatcaccca atgttaatac tactgcatca ggtgttgaag accttaacat cattcaggtg   3000

acaattccag atgatgataa tgaaagactc tcgaaagttg aaaaagctag acagctaaga   3060

gaacaagtga atgacctctt tagtcggaaa tttggtgaag ctattggtat gggttttcct   3120

gtgaaagttc cctacaggaa aatcacaatt aaccctggct gtgtggtggt tgatggcatg   3180

cccccggggg tgtccttcaa agcccccagc tacctggaaa tcagctccat gagaaggatc   3240

ttagactctg ccgagtttat caaattcacg gtcattagac catttccagg acttgtgatt   3300

aataaccagc tggttgatca gagtgagtca gaaggccccg tgatacaaga atcagctgaa   3360

ccaagccagt tggaagttcc agccacagaa gaaataaaag agactgatgg aagctctcag   3420

atcaagcaag aaccagaccc cacgtggtag acctcttccc tcctaggctt aaagtatcag   3480

tggttgagaa gagcttttcg gacctgttac taccccaagc tgtgtaatat acttgtataa   3540

cagaaatacc ttctatacaa accttttttt ctacttttag atagaaatgt ctactttttc   3600

agcagttctg tgaattaaag agcagagtga ctgtgggtct ggaatggctg gtgtacttgg   3660

gaatgtacta tcaggatttt acagcaatgc tgggaaatga cagggaaaat gacaggaatg   3720

aatctcacca gattttttat gtactcagca gagccttgag ttacggtgtt tattttccaa   3780

tcaagtgaag atatctccta cttctcctac tggaacatct cagcttctgc agtgaagaaa   3840

aattcctgtg atagttcagt tctttagttt ttctatttga aaaaaaaaaa tcatttaaat   3900

gatcctttgt tcacggctct ccttaatgac tgagtgaaca gttcctatct gtatatttga   3960

ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt tttttatcat aattaaaagc   4020

aaaaccatct ggatcaccta acagtcagag gtcagtatct cagcgtgtga attatagagg   4080

aaatacagag agaacctctt ccacttttac ttttcgtcca aataaaatgc atggtgtacc   4140

agaagttgaa gatcgggttg aggattgggg ctagctcgat gacactaagg ccccaacatc   4200

gcgggacctg ctgtggcgcg gattcttagg aacgctgttc tagccggccc cctctccagg   4260

ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa ccctgaggtg ccagcgcggg   4320

gagtgaggag gggtcagggg gctaaggatg caacctctga cgttctgcgc cttcctagga   4380

gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc agctctacaa   4440

gaagctaggc tctgtgacgg catagttttc agtagcttta tcacaatatt cacaatggag   4500

aattatatga catggtagca gaaataggcc cttttatgtg ttgcttctat tttacctcaa   4560

attgtagata tagggtaatc aataaaatcc atccatgcct ttcacacact aagt         4614


<210>  4233
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  4233

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala 



<210>  4234
<211>  3883
<212>  DNA
<213>  Homo sapiens

<400>  4234
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   2040

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2100

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2160

tgaaaggatc gtccgcggga gtaataaaat caagttcgtt gttaaaaaac ctgaactagt   2220

tatttcctac ttgcctcctg ggatggctag taaaataaac actaaagctt tgcagtcccc   2280

caaaagacca cgaagtcctg ggagtaattc aaaggttcct gaaattgagg tcaccgtgga   2340

aggccctaat aacaacaatc ctcaaacctc agctgttcga accccgaccc agactaacgg   2400

ttctaacgtt cccttcaagc cacgagggag agagttttcc tttgaggcct ggaatgccaa   2460

aatcacggac ctaaaacaga aagttgaaaa tctcttcaat gagaaatgtg gggaagctct   2520

tggccttaaa caagctgtga aggtgccgtt cgcgttattt gagtctttcc cggaagactt   2580

ttatgtggaa ggcttacctg agggtgtgcc attccgaaga ccatcgactt ttggcattcc   2640

gaggctggag aagatactca gaaacaaagc caaaattaag ttcatcatta aaaagcccga   2700

aatgtttgag acggcgatta aggagagcac ctcctctaag agccctccca gaaaaataaa   2760

ttcatcaccc aatgttaata ctactgcatc aggtgttgaa gaccttaaca tcattcaggt   2820

gacaattcca gatgatgata atgaaagact ctcgaaagtt gaaaaagcta gacagctaag   2880

agaacaagtg aatgacctct ttagtcggaa atttggtgaa gctattggta tgggttttcc   2940

tgtgaaagtt ccctacagga aaatcacaat taaccctggc tgtgtggtgg ttgatggcat   3000

gcccccgggg gtgtccttca aagcccccag ctacctggaa atcagctcca tgagaaggat   3060

cttagactct gccgagttta tcaaattcac ggtcattaga ccatttccag gacttgtgat   3120

taataaccag ctggttgatc agagtgagtc agaaggcccc gtgatacaag aatcagctga   3180

accaagccag ttggaagttc cagccacaga agaaataaaa gagactgatg gaagctctca   3240

gatcaagcaa gaaccagacc ccacgtggta gacctcttcc ctcctaggca aaaccatctg   3300

gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa ttatagagga aatacagaga   3360

gaacctcttc cacttttact tttcgtccaa ataaaatgca tggtgtacca gaagttgaag   3420

atcgggttga ggattggggc tagctcgatg acactaaggc cccaacatcg cgggacctgc   3480

tgtggcgcgg attcttagga acgctgttct agccggcccc ctctccaggg gtcgccgtgg   3540

ccggcattat ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg   3600

ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc ttcctaggag agtcttacat   3660

gtgttgagat ttcacaagca atgcgagttg taaaatacca gctctacaag aagctaggct   3720

ctgtgacggc atagttttca gtagctttat cacaatattc acaatggaga attatatgac   3780

atggtagcag aaataggccc ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat   3840

agggtaatca ataaaatcca tccatgcctt tcacacacta agt                     3883


<210>  4235
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  4235

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala 
            580                 585                 590


Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600                 605


<210>  4236
<211>  4144
<212>  DNA
<213>  Homo sapiens

<400>  4236
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gctcaagctc ttggactcac   1980

cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct tgtatgtgga   2040

aggcttgcca gaggggattc ccttccgaag ccctacctgg tttggaattc cacgacttga   2100

aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg aactagttat   2160

ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc agtcccccaa   2220

aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg   2280

ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga ctaacggttc   2340

taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga atgccaaaat   2400

cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg   2460

ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg aagactttta   2520

tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg gcattccgag   2580

gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa agcccgaaat   2640

gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa aaataaattc   2700

atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca ttcaggtgac   2760

aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac agctaagaga   2820

acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg gttttcctgt   2880

gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg atggcatgcc   2940

cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga gaaggatctt   3000

agactctgcc gagtttatca aattcacggt cattagacca tttccaggac ttgtgattaa   3060

taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat cagctgaacc   3120

aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa gctctcagat   3180

caagcaagaa ccagacccca cgtggtagac ctcttccctc ctaggcttaa agtatcagtg   3240

gttgagaaga gcttttcgga cctgttacta ccccaagctg tagccttgag ttacggtgtt   3300

tattttccaa tcaagtgaag atatctccta cttctcctac tggaacatct cagcttctgc   3360

agtgaagaaa aattcctgtg atagttcagt tctttagttt ttctatttga aaaaaaaaaa   3420

tcatttaaat gatcctttgt tcacggctct ccttaatgac tgagtgaaca gttcctatct   3480

gtatatttga ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt tttttatcat   3540

aattaaaagc aaaaccatct ggatcaccta acagtcagag gtcagtatct cagcgtgtga   3600

attatagagg aaatacagag agaacctctt ccacttttac ttttcgtcca aataaaatgc   3660

atggtgtacc agaagttgaa gatcgggttg aggattgggg ctagctcgat gacactaagg   3720

ccccaacatc gcgggacctg ctgtggcgcg gattcttagg aacgctgttc tagccggccc   3780

cctctccagg ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa ccctgaggtg   3840

ccagcgcggg gagtgaggag gggtcagggg gctaaggatg caacctctga cgttctgcgc   3900

cttcctagga gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc   3960

agctctacaa gaagctaggc tctgtgacgg catagttttc agtagcttta tcacaatatt   4020

cacaatggag aattatatga catggtagca gaaataggcc cttttatgtg ttgcttctat   4080

tttacctcaa attgtagata tagggtaatc aataaaatcc atccatgcct ttcacacact   4140

aagt                                                                4144


<210>  4237
<211>  928
<212>  PRT
<213>  Homo sapiens

<400>  4237

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro 
        515                 520                 525


Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu 
    530                 535                 540


Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu 
545                 550                 555                 560


Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro 
                565                 570                 575


Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn 
            580                 585                 590


Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn 
        595                 600                 605


Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn 
    610                 615                 620


Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser 
625                 630                 635                 640


Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp 
                645                 650                 655


Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn 
            660                 665                 670


Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro 
        675                 680                 685


Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu 
    690                 695                 700


Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg 
705                 710                 715                 720


Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys 
                725                 730                 735


Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys 
            740                 745                 750


Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala 
        755                 760                 765


Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp 
    770                 775                 780


Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu 
785                 790                 795                 800


Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met 
                805                 810                 815


Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly 
            820                 825                 830


Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro 
        835                 840                 845


Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu 
    850                 855                 860


Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn 
865                 870                 875                 880


Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu 
                885                 890                 895


Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys 
            900                 905                 910


Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
        915                 920                 925


<210>  4238
<211>  4467
<212>  DNA
<213>  Homo sapiens

<400>  4238
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgcttaga tttgttgaca gcggtttcct ggagtgctgt   1980

cttgagaacg attctgagga ggctcagcaa gaaagagtgt ttcagttgat tgggtgtgtc   2040

tgtcatggag aaggaactca agctcttgga ctcaccgagg cagtaaaagt accatatcct   2100

gtgtttgaat caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc   2160

cgaagcccta cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa   2220

atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct   2280

agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat   2340

tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc   2400

tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg   2460

agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa   2520

aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg   2580

ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg   2640

ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa   2700

gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc   2760

acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca   2820

tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga   2880

ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg   2940

aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca   3000

attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt caaagccccc   3060

agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc   3120

acggtcatta gaccatttcc aggacttgtg attaataacc agctggttga tcagagtgag   3180

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   3240

gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga ccccacgtgg   3300

tagacctctt ccctcctagg cttaaagtat cagtggttga gaagagcttt tcggacctgt   3360

tactacccca agctgtgtaa tatacttgta taacagaaat accttctata caaacctttt   3420

tttctacttt tagatagaaa tgtctacttt ttcagcagtt ctgtgaatta aagagcagag   3480

tgactgtggg tctggaatgg ctggtgtact tgggaatgta ctatcaggat tttacagcaa   3540

tgctgggaaa tgacagggaa aatgacagga atgaatctca ccagattttt tatgtactca   3600

gcagagcctt gagttacggt gtttattttc caatcaagtg aagatatctc ctacttctcc   3660

tactggaaca tctcagcttc tgcagtgaag aaaaattcct gtgatagttc agttctttag   3720

tttttctatt tgaaaaaaaa aaatcattta aatgatcctt tgttcacggc tctccttaat   3780

gactgagtga acagttccta tctgtatatt tgactaaacc ttttcctaag ctatctctca   3840

tggttcctat gtttttttat cataattaaa agcaaaacca tctggatcac ctaacagtca   3900

gaggtcagta tctcagcgtg tgaattatag aggaaataca gagagaacct cttccacttt   3960

tacttttcgt ccaaataaaa tgcatggtgt accagaagtt gaagatcggg ttgaggattg   4020

gggctagctc gatgacacta aggccccaac atcgcgggac ctgctgtggc gcggattctt   4080

aggaacgctg ttctagccgg ccccctctcc aggggtcgcc gtggccggca ttatttccta   4140

gttcttcttg taaccctgag gtgccagcgc ggggagtgag gaggggtcag ggggctaagg   4200

atgcaacctc tgacgttctg cgccttccta ggagagtctt acatgtgttg agatttcaca   4260

agcaatgcga gttgtaaaat accagctcta caagaagcta ggctctgtga cggcatagtt   4320

ttcagtagct ttatcacaat attcacaatg gagaattata tgacatggta gcagaaatag   4380

gcccttttat gtgttgcttc tattttacct caaattgtag atatagggta atcaataaaa   4440

tccatccatg cctttcacac actaagt                                       4467


<210>  4239
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  4239

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
            420                 425                 430


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
        435                 440                 445


Phe Asn Leu Lys Phe Ala 
    450


<210>  4240
<211>  7765
<212>  DNA
<213>  Homo sapiens

<400>  4240
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1920

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   1980

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttga   2040

aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg aactagttat   2100

ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc agtcccccaa   2160

aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg   2220

ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga ctaacggttc   2280

taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga atgccaaaat   2340

cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg   2400

ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg aagactttta   2460

tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg gcattccgag   2520

gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa agcccgaaat   2580

gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa aaataaattc   2640

atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca ttcaggtgac   2700

aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac agctaagaga   2760

acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg gttttcctgt   2820

gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg atggcatgcc   2880

cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga gaaggatctt   2940

agactctgcc gagtttatca aattcacggt cattaggtaa gtgagagttt cctgcttagt   3000

cacaggagcg aatctggagc tcatgaggct gactcttcta aaatgcagcc acaggtagtc   3060

atcgaatccg gcttcctatg ctgtgcaatc aacaaatcaa aataacttgt gtcatcatta   3120

gaatgtcaga tgtgcttcta cgaactaagc tgactctttt aattctttgg caaagggttg   3180

gcaaactagg actgtttgcc aaattcaggc tgcctcctat ttttagagtc ttcctgaaac   3240

acagctacac ccgtattatc catggctgct ttcctgtcac agtgagtaag tagctgggac   3300

tgagaaggca tggcctccaa agtctaaaat atttactctc tagcactttg tagaaaaacc   3360

ttagctaggc acagtggcta acgcctgtaa tcccagcatt ttgggaggcc aaggcaggca   3420

gatcacctga ggtcaggagt tccagaccag cctggccaac atggtgaaat cccatctcta   3480

caaaaataaa acagttagct gggcatgatg gcgggtgcct gtaatcccag ctactcggga   3540

ggctgaggca ggatagtcgc ttgaacccag gaggtggagg ttgcaatgag ccaagatcat   3600

gccactgcac tccagcctgg acgacagagt gagactccat cacaagaaaa aaagaacttt   3660

gtcaacctct gtcttagggc gccttgtcac aggcttcggg tcagacggat tcaaccttgc   3720

atcagccatt tgttagccag gtcactctgt tctttgtctg taaatgagat tgatcgttgt   3780

tcccactgag agtgtcagct ccttcccgta gagcaggcat gatgattgta ctcacctctg   3840

acaccattgt gagtgccaca ttccttccca cgtccttgtc actgtaagag atgcccacct   3900

gagcaccaac cccaggttat cttccccttt gtcttccagc cccccagaaa cagctacgac   3960

tcaacctacc caatcatttc atcatcagat tgccactgtc tctagttcag gtctcttggg   4020

actggcactc agaaatctca taataaatcc tcttgaggct tctcatacac tcgtcttctt   4080

ccaatcttct ttccctcaaa atctcatatt ttggttccac ttcacccacc gtcattctcc   4140

atatcactcc caggagttag gcaaaaagcc ccttccgttc ttccgtatgt taaacttaga   4200

atcactctgt tccctgctct gcgtttctat tttttgtttt tcctccattt actagtagct   4260

taacactttc taacagtgtt cttattattg atacgtatct atctcttcca taagcttata   4320

aggtcacgga taatacttct cattgtagta cgtaaatgac gtgggctaga tatgagttga   4380

ataaacagtt atacctgtaa attcttacag agtgaaaata aattgttata ctttacaatt   4440

tgtttctctc tttagaccat ttccaggact tgtgattaat aaccgtgagt attttgtgaa   4500

gtgttttgtt tttgtttttt cctggggtct gacgtgtgtg cgtgtgagtg tgtatacatg   4560

cttaacgtat atcacgttac ttcacctatg tcagtaacca ggccaaatac ttgttttagc   4620

cctcagtaaa aacaccaggc acttcctagt tgtaaaatta ttcaagcttc ttaacttcct   4680

atcctcgatg cacttaatca taaaatggta ataatagcac cgattttggg ggagtcgttc   4740

cagtagatgg aaagcatctg gaacaggtgt cagcaagctc ctgccgacgt gtatgcataa   4800

agttttattg aaaccaccat cgtgtccatt tgtttatggc agaactgaga gatggcagca   4860

gcaagtgtgt gcctgcaaaa cctaaaatat ttactaattg gctctgcaag aaaagagttt   4920

gcatccccct aacctagaac agtgtctagc ctctagtatg tgtttagcct acagtatgtg   4980

ctcagcgaat acaatctata tttattactg cttttatgac tgttataatt actgtgcttg   5040

gatttcgtta caaagtaagt cacaatgtgc ctgcttctgt tagtatttca gcacagtgcc   5100

tggcacacat ggggctctca aatattgctg agcgagtgaa caaatgtcct ttcaattcct   5160

taacgttgat gtcattttca atagtatttt gagccaaact taattttgcg agtgtgtttt   5220

gttttcttaa ctttattatt aaaaatgtat aaaagtgagg ccaggcgtgg tggctcacgc   5280

ctgtaatccc agcagtttgg gaggctgagg caggcggatc agttgaggtt gggagttgga   5340

gaccagcccg tccaacatgg tgaaagcctg tctctactaa aaatacaaaa atcagctggg   5400

tgtggtggcg cgtgcctgta atcccagcta ctcaggaggc tgaggcagga gagttgcttg   5460

aatcctagag gtggaggttg cagtgagctg agatcgtgcc attgcactcc agcctgggca   5520

acaagagcaa aactctgtcc caataaataa ataaataaaa tgttctcttt tgttcctgtt   5580

cttgtgcggt agtgtggtat agagttttat ggtaattact gtgaattagt gattctgagg   5640

gacatatcag aactctgagg tttgtttcct tctcatcttg agggaaacag caaatgtatg   5700

ttaaaatgct tttccaaggg aacaacacat ccttacatta tttaaaccaa tctgcttcat   5760

tttcagagct ggttgatcag agtgagtcag aaggccccgt gatacaagaa tcagctgaac   5820

caagccagtt ggaagttcca gccacagaag aaataaaaga gactgatgga agctctcaga   5880

tcaagcaaga accagacccc acgtggtaga cctcttccct cctagggtaa atcagcttct   5940

gtgtcaggga tgctgtgtgg tgtccatctg aaccccctgc atacgcgtag ctaatgtgat   6000

ctccccactt tcacataaga tggtggccct gccttcaggg aatgtgggag ccaggtggga   6060

gccttcccgg atatttaagc tagaagattc tacagggaga ttctccttgg atcaatatat   6120

gtctctcagt caaagatgta aaagcacttt tgccttaaaa agaatgttct gtttctaaat   6180

agagtcaacg ttgtcctcct cattggaatt cactatgagt cagaatcatt agactgactt   6240

ttttttttcc atagtaatag tattttgcag agtctcacag agctgcagat cttttgttca   6300

tcttgcagag ttaacaagtc tgatcctgtt agtccagatt tcttaaattt ggccaagtta   6360

taataggagc agtagcttga gacccgaagt caggaaactt tgacaatgga tttttttttt   6420

taatccagag acttgtactg gaatttgcct taccctgtca gctcatggac ttaaggtttc   6480

atcccgcttt atgagtgctt ctgaatccaa gtcattgtta cctgaatttg caaattaagt   6540

tgtgatattc gtgactgtta aattcctgta attagattaa cctctttgct tgcttgtttg   6600

ttttctctcc tattttagct taaagtatca gtggttgaga agagcttttc ggacctgtta   6660

ctaccccaag ctgtgtaata tacttgtata acagaaatac cttctataca aacctttttt   6720

tctactttta gatagaaatg tctacttttt cagcagttct gtgaattaaa gagcagagtg   6780

actgtgggtc tggaatggct ggtgtacttg ggaatgtact atcaggattt tacagcaatg   6840

ctgggaaatg acagggaaaa tgacaggaat gaatctcacc agatttttta tgtactcagc   6900

agagccttga gttacggtgt ttattttcca atcaagtgaa gatatctcct acttctccta   6960

ctggaacatc tcagcttctg cagtgaagaa aaattcctgt gatagttcag ttctttagtt   7020

tttctatttg aaaaaaaaaa atcatttaaa tgatcctttg ttcacggctc tccttaatga   7080

ctgagtgaac agttcctatc tgtatatttg actaaacctt ttcctaagct atctctcatg   7140

gttcctatgt ttttttatca taattaaaag caaaaccatc tggatcacct aacagtcaga   7200

ggtcagtatc tcagcgtgtg aattatagag gaaatacaga gagaacctct tccactttta   7260

cttttcgtcc aaataaaatg catggtgtac cagaagttga agatcgggtt gaggattggg   7320

gctagctcga tgacactaag gccccaacat cgcgggacct gctgtggcgc ggattcttag   7380

gaacgctgtt ctagccggcc ccctctccag gggtcgccgt ggccggcatt atttcctagt   7440

tcttcttgta accctgaggt gccagcgcgg ggagtgagga ggggtcaggg ggctaaggat   7500

gcaacctctg acgttctgcg ccttcctagg agagtcttac atgtgttgag atttcacaag   7560

caatgcgagt tgtaaaatac cagctctaca agaagctagg ctctgtgacg gcatagtttt   7620

cagtagcttt atcacaatat tcacaatgga gaattatatg acatggtagc agaaataggc   7680

ccttttatgt gttgcttcta ttttacctca aattgtagat atagggtaat caataaaatc   7740

catccatgcc tttcacacac taagt                                         7765


<210>  4241
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  4241

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
            500                 505                 510


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
        515                 520                 525


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
    530                 535                 540


Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu 
545                 550                 555                 560


Lys Asn Leu Asn 



<210>  4242
<211>  3815
<212>  DNA
<213>  Homo sapiens

<400>  4242
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagctca agctcttgga ctcaccgagg   1980

cagtaaaagt accatatcct gtgtttgaat caaacccgga gttcttgtat gtggaaggct   2040

tgccagaggg gattcccttc cgaagcccta cctggtttgg aattccacga cttgaaagga   2100

tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa acctgaacta gttatttcct   2160

acttgcctcc tgggatggct agtaaaataa acactaaagc tttgcagtcc cccaaaagac   2220

cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta   2280

ataacaacaa tcctcaaacc tcagctgttc gaaccccgac ccagactaac ggttctaacg   2340

ttcccttcaa gccacgaggg agagagtttt cctttgaggc ctggaatgcc aaaatcacgg   2400

acctaaaaca gaaagttgaa aatctcttca atgagaaatg tggggaagct cttggcctta   2460

aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg   2520

aaggcttacc tgagggtgtg ccattccgaa gaccatcgac ttttggcatt ccgaggctgg   2580

agaagatact cagaaacaaa gccaaaatta agttcatcat taaaaagccc gaaatgtttg   2640

agacggcgat taaggagagc acctcctcta agagccctcc cagaaaaata aattcatcac   2700

ccaatgttaa tactactgca tcaggtgttg aagaccttaa catcattcag gtgacaattc   2760

cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta agagaacaag   2820

tgaatgacct ctttagtcgg aaatttggtg aagctattgg tatgggtttt cctgtgaaag   2880

ttccctacag gaaaatcaca attaaccctg gctgtgtggt ggttgatggc atgcccccgg   2940

gggtgtcctt caaagccccc agctacctgg aaatcagctc catgagaagg atcttagact   3000

ctgccgagtt tatcaaattc acggtcatta gaccatttcc aggacttgtg attaataacc   3060

agctggttga tcagagtgag tcagaaggcc ccgtgataca agaatcagct gaaccaagcc   3120

agttggaagt tccagccaca gaagaaataa aagagactga tggaagctct cagatcaagc   3180

aagaaccaga ccccacgtgg tagacctctt ccctcctagg caaaaccatc tggatcacct   3240

aacagtcaga ggtcagtatc tcagcgtgtg aattatagag gaaatacaga gagaacctct   3300

tccactttta cttttcgtcc aaataaaatg catggtgtac cagaagttga agatcgggtt   3360

gaggattggg gctagctcga tgacactaag gccccaacat cgcgggacct gctgtggcgc   3420

ggattcttag gaacgctgtt ctagccggcc ccctctccag gggtcgccgt ggccggcatt   3480

atttcctagt tcttcttgta accctgaggt gccagcgcgg ggagtgagga ggggtcaggg   3540

ggctaaggat gcaacctctg acgttctgcg ccttcctagg agagtcttac atgtgttgag   3600

atttcacaag caatgcgagt tgtaaaatac cagctctaca agaagctagg ctctgtgacg   3660

gcatagtttt cagtagcttt atcacaatat tcacaatgga gaattatatg acatggtagc   3720

agaaataggc ccttttatgt gttgcttcta ttttacctca aattgtagat atagggtaat   3780

caataaaatc catccatgcc tttcacacac taagt                              3815


<210>  4243
<211>  933
<212>  PRT
<213>  Homo sapiens

<400>  4243

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
        515                 520                 525


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
    530                 535                 540


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
545                 550                 555                 560


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
                565                 570                 575


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
            580                 585                 590


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
        595                 600                 605


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
    610                 615                 620


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
625                 630                 635                 640


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
                645                 650                 655


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
            660                 665                 670


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
        675                 680                 685


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
    690                 695                 700


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
705                 710                 715                 720


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
                725                 730                 735


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
            740                 745                 750


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
        755                 760                 765


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
    770                 775                 780


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
785                 790                 795                 800


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
                805                 810                 815


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
            820                 825                 830


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
        835                 840                 845


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
    850                 855                 860


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro 
865                 870                 875                 880


Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly 
                885                 890                 895


Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala 
            900                 905                 910


Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu 
        915                 920                 925


Pro Asp Pro Thr Trp 
    930


<210>  4244
<211>  4272
<212>  DNA
<213>  Homo sapiens

<400>  4244
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gtcaaagaag attggaatgt   1980

cagaattacc aagctacgga agcaagtgga agagattttt aatttgaaat ttgcttagat   2040

ttgttgacag cggtttcctg gagtgctgtc ttgagaacga ttctgaggag gctcagcaag   2100

aaagagtgtt tcagttgatt gggtgtgtct gtcatggaga aggaactcaa gctcttggac   2160

tcaccgaggc agtaaaagta ccatatcctg tgtttgaatc aaacccggag ttcttgtatg   2220

tggaaggctt gccagagggg attcccttcc gaagccctac ctggtttgga attccacgac   2280

ttgaaaggat cgtccgcggg agtaataaaa tcaagttcgt tgttaaaaaa cctgaactag   2340

ttatttccta cttgcctcct gggatggcta gtaaaataaa cactaaagct ttgcagtccc   2400

ccaaaagacc acgaagtcct gggagtaatt caaaggttcc tgaaattgag gtcaccgtgg   2460

aaggccctaa taacaacaat cctcaaacct cagctgttcg aaccccgacc cagactaacg   2520

gttctaacgt tcccttcaag ccacgaggga gagagttttc ctttgaggcc tggaatgcca   2580

aaatcacgga cctaaaacag aaagttgaaa atctcttcaa tgagaaatgt ggggaagctc   2640

ttggccttaa acaagctgtg aaggtgccgt tcgcgttatt tgagtctttc ccggaagact   2700

tttatgtgga aggcttacct gagggtgtgc cattccgaag accatcgact tttggcattc   2760

cgaggctgga gaagatactc agaaacaaag ccaaaattaa gttcatcatt aaaaagcccg   2820

aaatgtttga gacggcgatt aaggagagca cctcctctaa gagccctccc agaaaaataa   2880

attcatcacc caatgttaat actactgcat caggtgttga agaccttaac atcattcagg   2940

tgacaattcc agatgatgat aatgaaagac tctcgaaagt tgaaaaagct agacagctaa   3000

gagaacaagt gaatgacctc tttagtcgga aatttggtga agctattggt atgggttttc   3060

ctgtgaaagt tccctacagg aaaatcacaa ttaaccctgg ctgtgtggtg gttgatggca   3120

tgcccccggg ggtgtccttc aaagccccca gctacctgga aatcagctcc atgagaagga   3180

tcttagactc tgccgagttt atcaaattca cggtcattag accatttcca ggacttgtga   3240

ttaataacca gctggttgat cagagtgagt cagaaggccc cgtgatacaa gaatcagctg   3300

aaccaagcca gttggaagtt ccagccacag aagaaataaa agagactgat ggaagctctc   3360

agatcaagca agaaccagac cccacgtggt agacctcttc cctcctagga gccttgagtt   3420

acggtgttta ttttccaatc aagtgaagat atctcctact tctcctactg gaacatctca   3480

gcttctgcag tgaagaaaaa ttcctgtgat agttcagttc tttagttttt ctatttgaaa   3540

aaaaaaaatc atttaaatga tcctttgttc acggctctcc ttaatgactg agtgaacagt   3600

tcctatctgt atatttgact aaaccttttc ctaagctatc tctcatggtt cctatgtttt   3660

tttatcataa ttaaaagcaa aaccatctgg atcacctaac agtcagaggt cagtatctca   3720

gcgtgtgaat tatagaggaa atacagagag aacctcttcc acttttactt ttcgtccaaa   3780

taaaatgcat ggtgtaccag aagttgaaga tcgggttgag gattggggct agctcgatga   3840

cactaaggcc ccaacatcgc gggacctgct gtggcgcgga ttcttaggaa cgctgttcta   3900

gccggccccc tctccagggg tcgccgtggc cggcattatt tcctagttct tcttgtaacc   3960

ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc taaggatgca acctctgacg   4020

ttctgcgcct tcctaggaga gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt   4080

aaaataccag ctctacaaga agctaggctc tgtgacggca tagttttcag tagctttatc   4140

acaatattca caatggagaa ttatatgaca tggtagcaga aataggccct tttatgtgtt   4200

gcttctattt tacctcaaat tgtagatata gggtaatcaa taaaatccat ccatgccttt   4260

cacacactaa gt                                                       4272


<210>  4245
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  4245

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535


<210>  4246
<211>  4283
<212>  DNA
<213>  Homo sapiens

<400>  4246
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agctcaagct cttggactca ccgaggcagt aaaagtacca tatcctgtgt   1920

ttgaatcaaa cccggagttc ttgtatgtgg aaggcttgcc agaggggatt cccttccgaa   1980

gccctacctg gtttggaatt ccacgacttg aaaggatcgt ccgcgggagt aataaaatca   2040

agttcgttgt taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta   2100

aaataaacac taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa   2160

aggttcctga aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag   2220

ctgttcgaac cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag   2280

agttttcctt tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc   2340

tcttcaatga gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg   2400

cgttatttga gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat   2460

tccgaagacc atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca   2520

aaattaagtt catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct   2580

cctctaagag ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag   2640

gtgttgaaga ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct   2700

cgaaagttga aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat   2760

ttggtgaagc tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta   2820

accctggctg tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct   2880

acctggaaat cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg   2940

tcattagacc atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag   3000

aaggccccgt gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag   3060

aaataaaaga gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga   3120

cctcttccct cctaggctta aagtatcagt ggttgagaag agcttttcgg acctgttact   3180

accccaagct gtgtaatata cttgtataac agaaatacct tctatacaaa cctttttttc   3240

tacttttaga tagaaatgtc tactttttca gcagttctgt gaattaaaga gcagagtgac   3300

tgtgggtctg gaatggctgg tgtacttggg aatgtactat caggatttta cagcaatgct   3360

gggaaatgac agggaaaatg acaggaatga atctcaccag attttttatg tactcagcag   3420

agccttgagt tacggtgttt attttccaat caagtgaaga tatctcctac ttctcctact   3480

ggaacatctc agcttctgca gtgaagaaaa attcctgtga tagttcagtt ctttagtttt   3540

tctatttgaa aaaaaaaaat catttaaatg atcctttgtt cacggctctc cttaatgact   3600

gagtgaacag ttcctatctg tatatttgac taaacctttt cctaagctat ctctcatggt   3660

tcctatgttt ttttatcata attaaaagca aaaccatctg gatcacctaa cagtcagagg   3720

tcagtatctc agcgtgtgaa ttatagagga aatacagaga gaacctcttc cacttttact   3780

tttcgtccaa ataaaatgca tggtgtacca gaagttgaag atcgggttga ggattggggc   3840

tagctcgatg acactaaggc cccaacatcg cgggacctgc tgtggcgcgg attcttagga   3900

acgctgttct agccggcccc ctctccaggg gtcgccgtgg ccggcattat ttcctagttc   3960

ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc   4020

aacctctgac gttctgcgcc ttcctaggag agtcttacat gtgttgagat ttcacaagca   4080

atgcgagttg taaaatacca gctctacaag aagctaggct ctgtgacggc atagttttca   4140

gtagctttat cacaatattc acaatggaga attatatgac atggtagcag aaataggccc   4200

ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat agggtaatca ataaaatcca   4260

tccatgcctt tcacacacta agt                                           4283


<210>  4247
<211>  844
<212>  PRT
<213>  Homo sapiens

<400>  4247

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala 
            420                 425                 430


Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser 
        435                 440                 445


Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
    450                 455                 460


Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg 
465                 470                 475                 480


Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile 
                485                 490                 495


Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu 
            500                 505                 510


Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro 
        515                 520                 525


Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr 
    530                 535                 540


Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe 
545                 550                 555                 560


Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile 
                565                 570                 575


Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly 
            580                 585                 590


Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe 
        595                 600                 605


Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val 
    610                 615                 620


Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile 
625                 630                 635                 640


Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met 
                645                 650                 655


Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg 
            660                 665                 670


Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu 
        675                 680                 685


Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg 
    690                 695                 700


Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp 
705                 710                 715                 720


Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val 
                725                 730                 735


Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val 
            740                 745                 750


Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu 
        755                 760                 765


Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe 
    770                 775                 780


Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val 
785                 790                 795                 800


Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro 
                805                 810                 815


Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly 
            820                 825                 830


Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
        835                 840


<210>  4248
<211>  5122
<212>  DNA
<213>  Homo sapiens

<400>  4248
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagc tcaagctctt ggactcaccg   2040

aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag   2100

gcttgccaga ggggattccc ttccgaagcc ctacctggtt tggaattcca cgacttgaaa   2160

ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt   2220

cctacttgcc tcctgggatg gctagtaaaa taaacactaa agctttgcag tcccccaaaa   2280

gaccacgaag tcctgggagt aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc   2340

ctaataacaa caatcctcaa acctcagctg ttcgaacccc gacccagact aacggttcta   2400

acgttccctt caagccacga gggagagagt tttcctttga ggcctggaat gccaaaatca   2460

cggacctaaa acagaaagtt gaaaatctct tcaatgagaa atgtggggaa gctcttggcc   2520

ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc tttcccggaa gacttttatg   2580

tggaaggctt acctgagggt gtgccattcc gaagaccatc gacttttggc attccgaggc   2640

tggagaagat actcagaaac aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt   2700

ttgagacggc gattaaggag agcacctcct ctaagagccc tcccagaaaa ataaattcat   2760

cacccaatgt taatactact gcatcaggtg ttgaagacct taacatcatt caggtgacaa   2820

ttccagatga tgataatgaa agactctcga aagttgaaaa agctagacag ctaagagaac   2880

aagtgaatga cctctttagt cggaaatttg gtgaagctat tggtatgggt tttcctgtga   2940

aagttcccta caggaaaatc acaattaacc ctggctgtgt ggtggttgat ggcatgcccc   3000

cgggggtgtc cttcaaagcc cccagctacc tggaaatcag ctccatgaga aggatcttag   3060

actctgccga gtttatcaaa ttcacggtca ttagaccatt tccaggactt gtgattaata   3120

accagctggt tgatcagagt gagtcagaag gccccgtgat acaagaatca gctgaaccaa   3180

gccagttgga agttccagcc acagaagaaa taaaagagac tgatggaagc tctcagatca   3240

agcaagaacc agaccccacg tggtagacct cttccctcct agggtaaatc agcttctgtg   3300

tcagggatgc tgtgtggtgt ccatctgaac cccctgcata cgcgtagcta atgtgatctc   3360

cccactttca cataagatgg tggccctgcc ttcagggaat gtgggagcca ggtgggagcc   3420

ttcccggata tttaagctag aagattctac agggagattc tccttggatc aatatatgtc   3480

tctcagtcaa agatgtaaaa gcacttttgc cttaaaaaga atgttctgtt tctaaataga   3540

gtcaacgttg tcctcctcat tggaattcac tatgagtcag aatcattaga ctgacttttt   3600

tttttccata gtaatagtat tttgcagagt ctcacagagc tgcagatctt ttgttcatct   3660

tgcagagtta acaagtctga tcctgttagt ccagatttct taaatttggc caagttataa   3720

taggagcagt agcttgagac ccgaagtcag gaaactttga caatggattt ttttttttaa   3780

tccagagact tgtactggaa tttgccttac cctgtcagct catggactta aggtttcatc   3840

ccgctttatg agtgcttctg aatccaagtc attgttacct gaatttgcaa attaagttgt   3900

gatattcgtg actgttaaat tcctgtaatt agattaacct ctttgcttgc ttgtttgttt   3960

tctctcctat tttagcttaa agtatcagtg gttgagaaga gcttttcgga cctgttacta   4020

ccccaagctg tgtaatatac ttgtataaca gaaatacctt ctatacaaac ctttttttct   4080

acttttagat agaaatgtct actttttcag cagttctgtg aattaaagag cagagtgact   4140

gtgggtctgg aatggctggt gtacttggga atgtactatc aggattttac agcaatgctg   4200

ggaaatgaca gggaaaatga caggaatgaa tctcaccaga ttttttatgt actcagcaga   4260

gccttgagtt acggtgttta ttttccaatc aagtgaagat atctcctact tctcctactg   4320

gaacatctca gcttctgcag tgaagaaaaa ttcctgtgat agttcagttc tttagttttt   4380

ctatttgaaa aaaaaaaatc atttaaatga tcctttgttc acggctctcc ttaatgactg   4440

agtgaacagt tcctatctgt atatttgact aaaccttttc ctaagctatc tctcatggtt   4500

cctatgtttt tttatcataa ttaaaagcaa aaccatctgg atcacctaac agtcagaggt   4560

cagtatctca gcgtgtgaat tatagaggaa atacagagag aacctcttcc acttttactt   4620

ttcgtccaaa taaaatgcat ggtgtaccag aagttgaaga tcgggttgag gattggggct   4680

agctcgatga cactaaggcc ccaacatcgc gggacctgct gtggcgcgga ttcttaggaa   4740

cgctgttcta gccggccccc tctccagggg tcgccgtggc cggcattatt tcctagttct   4800

tcttgtaacc ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc taaggatgca   4860

acctctgacg ttctgcgcct tcctaggaga gtcttacatg tgttgagatt tcacaagcaa   4920

tgcgagttgt aaaataccag ctctacaaga agctaggctc tgtgacggca tagttttcag   4980

tagctttatc acaatattca caatggagaa ttatatgaca tggtagcaga aataggccct   5040

tttatgtgtt gcttctattt tacctcaaat tgtagatata gggtaatcaa taaaatccat   5100

ccatgccttt cacacactaa gt                                            5122


<210>  4249
<211>  954
<212>  PRT
<213>  Homo sapiens

<400>  4249

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly 
    530                 535                 540


Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro 
545                 550                 555                 560


Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser 
                565                 570                 575


Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser 
            580                 585                 590


Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr 
        595                 600                 605


Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser 
    610                 615                 620


Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile 
625                 630                 635                 640


Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala 
                645                 650                 655


Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro 
            660                 665                 670


Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp 
        675                 680                 685


Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala 
    690                 695                 700


Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser 
705                 710                 715                 720


Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe 
                725                 730                 735


Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg 
            740                 745                 750


Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu 
        755                 760                 765


Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile 
    770                 775                 780


Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu 
785                 790                 795                 800


Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser 
                805                 810                 815


Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe 
            820                 825                 830


Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val 
        835                 840                 845


Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly 
    850                 855                 860


Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser 
865                 870                 875                 880


Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val 
                885                 890                 895


Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln 
            900                 905                 910


Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln 
        915                 920                 925


Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser 
    930                 935                 940


Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  4250
<211>  5067
<212>  DNA
<213>  Homo sapiens

<400>  4250
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   1980

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2040

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2100

tgaaaggatc gtccgcggga gtaataaaat caagttcgtt gttaaaaaac ctgaactagt   2160

tatttcctac ttgcctcctg ggatggctag taaaataaac actaaagctt tgcagtcccc   2220

caaaagacca cgaagtcctg ggagtaattc aaaggttcct gaaattgagg tcaccgtgga   2280

aggccctaat aacaacaatc ctcaaacctc agctgttcga accccgaccc agactaacgg   2340

ttctaacgtt cccttcaagc cacgagggag agagttttcc tttgaggcct ggaatgccaa   2400

aatcacggac ctaaaacaga aagttgaaaa tctcttcaat gagaaatgtg gggaagctct   2460

tggccttaaa caagctgtga aggtgccgtt cgcgttattt gagtctttcc cggaagactt   2520

ttatgtggaa ggcttacctg agggtgtgcc attccgaaga ccatcgactt ttggcattcc   2580

gaggctggag aagatactca gaaacaaagc caaaattaag ttcatcatta aaaagcccga   2640

aatgtttgag acggcgatta aggagagcac ctcctctaag agccctccca gaaaaataaa   2700

ttcatcaccc aatgttaata ctactgcatc aggtgttgaa gaccttaaca tcattcaggt   2760

gacaattcca gatgatgata atgaaagact ctcgaaagtt gaaaaagcta gacagctaag   2820

agaacaagtg aatgacctct ttagtcggaa atttggtgaa gctattggta tgggttttcc   2880

tgtgaaagtt ccctacagga aaatcacaat taaccctggc tgtgtggtgg ttgatggcat   2940

gcccccgggg gtgtccttca aagcccccag ctacctggaa atcagctcca tgagaaggat   3000

cttagactct gccgagttta tcaaattcac ggtcattaga ccatttccag gacttgtgat   3060

taataaccag ctggttgatc agagtgagtc agaaggcccc gtgatacaag aatcagctga   3120

accaagccag ttggaagttc cagccacaga agaaataaaa gagactgatg gaagctctca   3180

gatcaagcaa gaaccagacc ccacgtggta gacctcttcc ctcctagggt aaatcagctt   3240

ctgtgtcagg gatgctgtgt ggtgtccatc tgaaccccct gcatacgcgt agctaatgtg   3300

atctccccac tttcacataa gatggtggcc ctgccttcag ggaatgtggg agccaggtgg   3360

gagccttccc ggatatttaa gctagaagat tctacaggga gattctcctt ggatcaatat   3420

atgtctctca gtcaaagatg taaaagcact tttgccttaa aaagaatgtt ctgtttctaa   3480

atagagtcaa cgttgtcctc ctcattggaa ttcactatga gtcagaatca ttagactgac   3540

tttttttttt ccatagtaat agtattttgc agagtctcac agagctgcag atcttttgtt   3600

catcttgcag agttaacaag tctgatcctg ttagtccaga tttcttaaat ttggccaagt   3660

tataatagga gcagtagctt gagacccgaa gtcaggaaac tttgacaatg gatttttttt   3720

tttaatccag agacttgtac tggaatttgc cttaccctgt cagctcatgg acttaaggtt   3780

tcatcccgct ttatgagtgc ttctgaatcc aagtcattgt tacctgaatt tgcaaattaa   3840

gttgtgatat tcgtgactgt taaattcctg taattagatt aacctctttg cttgcttgtt   3900

tgttttctct cctattttag cttaaagtat cagtggttga gaagagcttt tcggacctgt   3960

tactacccca agctgtgtaa tatacttgta taacagaaat accttctata caaacctttt   4020

tttctacttt tagatagaaa tgtctacttt ttcagcagtt ctgtgaatta aagagcagag   4080

tgactgtggg tctggaatgg ctggtgtact tgggaatgta ctatcaggat tttacagcaa   4140

tgctgggaaa tgacagggaa aatgacagga atgaatctca ccagattttt tatgtactca   4200

gcagagcctt gagttacggt gtttattttc caatcaagtg aagatatctc ctacttctcc   4260

tactggaaca tctcagcttc tgcagtgaag aaaaattcct gtgatagttc agttctttag   4320

tttttctatt tgaaaaaaaa aaatcattta aatgatcctt tgttcacggc tctccttaat   4380

gactgagtga acagttccta tctgtatatt tgactaaacc ttttcctaag ctatctctca   4440

tggttcctat gtttttttat cataattaaa agcaaaacca tctggatcac ctaacagtca   4500

gaggtcagta tctcagcgtg tgaattatag aggaaataca gagagaacct cttccacttt   4560

tacttttcgt ccaaataaaa tgcatggtgt accagaagtt gaagatcggg ttgaggattg   4620

gggctagctc gatgacacta aggccccaac atcgcgggac ctgctgtggc gcggattctt   4680

aggaacgctg ttctagccgg ccccctctcc aggggtcgcc gtggccggca ttatttccta   4740

gttcttcttg taaccctgag gtgccagcgc ggggagtgag gaggggtcag ggggctaagg   4800

atgcaacctc tgacgttctg cgccttccta ggagagtctt acatgtgttg agatttcaca   4860

agcaatgcga gttgtaaaat accagctcta caagaagcta ggctctgtga cggcatagtt   4920

ttcagtagct ttatcacaat attcacaatg gagaattata tgacatggta gcagaaatag   4980

gcccttttat gtgttgcttc tattttacct caaattgtag atatagggta atcaataaaa   5040

tccatccatg cctttcacac actaagt                                       5067


<210>  4251
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  4251

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile 
        515                 520                 525


Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
545                 550                 555                 560


Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys 
                565                 570                 575


Ser Ser Ser Leu Leu Lys Asn Leu Asn 
            580                 585


<210>  4252
<211>  7239
<212>  DNA
<213>  Homo sapiens

<400>  4252
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   2040

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2100

taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2160

ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2220

ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2280

ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2340

ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2400

atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2460

agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2520

agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2580

tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2640

ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2700

tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2760

ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2820

atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2880

ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2940

tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   3000

ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   3060

tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3120

ttatcaaatt cacggtcatt aggtaagtga gagtttcctg cttagtcaca ggagcgaatc   3180

tggagctcat gaggctgact cttctaaaat gcagccacag gtagtcatcg aatccggctt   3240

cctatgctgt gcaatcaaca aatcaaaata acttgtgtca tcattagaat gtcagatgtg   3300

cttctacgaa ctaagctgac tcttttaatt ctttggcaaa gggttggcaa actaggactg   3360

tttgccaaat tcaggctgcc tcctattttt agagtcttcc tgaaacacag ctacacccgt   3420

attatccatg gctgctttcc tgtcacagtg agtaagtagc tgggactgag aaggcatggc   3480

ctccaaagtc taaaatattt actctctagc actttgtaga aaaaccttag ctaggcacag   3540

tggctaacgc ctgtaatccc agcattttgg gaggccaagg caggcagatc acctgaggtc   3600

aggagttcca gaccagcctg gccaacatgg tgaaatccca tctctacaaa aataaaacag   3660

ttagctgggc atgatggcgg gtgcctgtaa tcccagctac tcgggaggct gaggcaggat   3720

agtcgcttga acccaggagg tggaggttgc aatgagccaa gatcatgcca ctgcactcca   3780

gcctggacga cagagtgaga ctccatcaca agaaaaaaag aactttgtca acctctgtct   3840

tagggcgcct tgtcacaggc ttcgggtcag acggattcaa ccttgcatca gccatttgtt   3900

agccaggtca ctctgttctt tgtctgtaaa tgagattgat cgttgttccc actgagagtg   3960

tcagctcctt cccgtagagc aggcatgatg attgtactca cctctgacac cattgtgagt   4020

gccacattcc ttcccacgtc cttgtcactg taagagatgc ccacctgagc accaacccca   4080

ggttatcttc ccctttgtct tccagccccc cagaaacagc tacgactcaa cctacccaat   4140

catttcatca tcagattgcc actgtctcta gttcaggtct cttgggactg gcactcagaa   4200

atctcataat aaatcctctt gaggcttctc atacactcgt cttcttccaa tcttctttcc   4260

ctcaaaatct catattttgg ttccacttca cccaccgtca ttctccatat cactcccagg   4320

agttaggcaa aaagcccctt ccgttcttcc gtatgttaaa cttagaatca ctctgttccc   4380

tgctctgcgt ttctattttt tgtttttcct ccatttacta gtagcttaac actttctaac   4440

agtgttctta ttattgatac gtatctatct cttccataag cttataaggt cacggataat   4500

acttctcatt gtagtacgta aatgacgtgg gctagatatg agttgaataa acagttatac   4560

ctgtaaattc ttacagagtg aaaataaatt gttatacttt acaatttgtt tctctcttta   4620

gaccatttcc aggacttgtg attaataacc gtgagtattt tgtgaagtgt tttgtttttg   4680

ttttttcctg gggtctgacg tgtgtgcgtg tgagtgtgta tacatgctta acgtatatca   4740

cgttacttca cctatgtcag taaccaggcc aaatacttgt tttagccctc agtaaaaaca   4800

ccaggcactt cctagttgta aaattattca agcttcttaa cttcctatcc tcgatgcact   4860

taatcataaa atggtaataa tagcaccgat tttgggggag tcgttccagt agatggaaag   4920

catctggaac aggtgtcagc aagctcctgc cgacgtgtat gcataaagtt ttattgaaac   4980

caccatcgtg tccatttgtt tatggcagaa ctgagagatg gcagcagcaa gtgtgtgcct   5040

gcaaaaccta aaatatttac taattggctc tgcaagaaaa gagtttgcat ccccctaacc   5100

tagaacagtg tctagcctct agtatgtgtt tagcctacag tatgtgctca gcgaatacaa   5160

tctatattta ttactgcttt tatgactgtt ataattactg tgcttggatt tcgttacaaa   5220

gtaagtcaca atgtgcctgc ttctgttagt atttcagcac agtgcctggc acacatgggg   5280

ctctcaaata ttgctgagcg agtgaacaaa tgtcctttca attccttaac gttgatgtca   5340

ttttcaatag tattttgagc caaacttaat tttgcgagtg tgttttgttt tcttaacttt   5400

attattaaaa atgtataaaa gtgaggccag gcgtggtggc tcacgcctgt aatcccagca   5460

gtttgggagg ctgaggcagg cggatcagtt gaggttggga gttggagacc agcccgtcca   5520

acatggtgaa agcctgtctc tactaaaaat acaaaaatca gctgggtgtg gtggcgcgtg   5580

cctgtaatcc cagctactca ggaggctgag gcaggagagt tgcttgaatc ctagaggtgg   5640

aggttgcagt gagctgagat cgtgccattg cactccagcc tgggcaacaa gagcaaaact   5700

ctgtcccaat aaataaataa ataaaatgtt ctcttttgtt cctgttcttg tgcggtagtg   5760

tggtatagag ttttatggta attactgtga attagtgatt ctgagggaca tatcagaact   5820

ctgaggtttg tttccttctc atcttgaggg aaacagcaaa tgtatgttaa aatgcttttc   5880

caagggaaca acacatcctt acattattta aaccaatctg cttcattttc agagctggtt   5940

gatcagagtg agtcagaagg ccccgtgata caagaatcag ctgaaccaag ccagttggaa   6000

gttccagcca cagaagaaat aaaagagact gatggaagct ctcagatcaa gcaagaacca   6060

gaccccacgt ggtagacctc ttccctccta ggcttaaagt atcagtggtt gagaagagct   6120

tttcggacct gttactaccc caagctgtgt aatatacttg tataacagaa ataccttcta   6180

tacaaacctt tttttctact tttagataga aatgtctact ttttcagcag ttctgtgaat   6240

taaagagcag agtgactgtg ggtctggaat ggctggtgta cttgggaatg tactatcagg   6300

attttacagc aatgctggga aatgacaggg aaaatgacag gaatgaatct caccagattt   6360

tttatgtact cagcagagcc ttgagttacg gtgtttattt tccaatcaag tgaagatatc   6420

tcctacttct cctactggaa catctcagct tctgcagtga agaaaaattc ctgtgatagt   6480

tcagttcttt agtttttcta tttgaaaaaa aaaaatcatt taaatgatcc tttgttcacg   6540

gctctcctta atgactgagt gaacagttcc tatctgtata tttgactaaa ccttttccta   6600

agctatctct catggttcct atgttttttt atcataatta aaagcaaaac catctggatc   6660

acctaacagt cagaggtcag tatctcagcg tgtgaattat agaggaaata cagagagaac   6720

ctcttccact tttacttttc gtccaaataa aatgcatggt gtaccagaag ttgaagatcg   6780

ggttgaggat tggggctagc tcgatgacac taaggcccca acatcgcggg acctgctgtg   6840

gcgcggattc ttaggaacgc tgttctagcc ggccccctct ccaggggtcg ccgtggccgg   6900

cattatttcc tagttcttct tgtaaccctg aggtgccagc gcggggagtg aggaggggtc   6960

agggggctaa ggatgcaacc tctgacgttc tgcgccttcc taggagagtc ttacatgtgt   7020

tgagatttca caagcaatgc gagttgtaaa ataccagctc tacaagaagc taggctctgt   7080

gacggcatag ttttcagtag ctttatcaca atattcacaa tggagaatta tatgacatgg   7140

tagcagaaat aggccctttt atgtgttgct tctattttac ctcaaattgt agatataggg   7200

taatcaataa aatccatcca tgcctttcac acactaagt                          7239


<210>  4253
<211>  853
<212>  PRT
<213>  Homo sapiens

<400>  4253

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
465                 470                 475                 480


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
                485                 490                 495


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
            500                 505                 510


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
        515                 520                 525


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
    530                 535                 540


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
545                 550                 555                 560


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
                565                 570                 575


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
            580                 585                 590


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
        595                 600                 605


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
    610                 615                 620


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
625                 630                 635                 640


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
                645                 650                 655


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
            660                 665                 670


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
        675                 680                 685


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
    690                 695                 700


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
705                 710                 715                 720


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
                725                 730                 735


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
            740                 745                 750


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
        755                 760                 765


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
    770                 775                 780


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
785                 790                 795                 800


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
                805                 810                 815


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
            820                 825                 830


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
        835                 840                 845


Phe Thr Val Ile Arg 
    850


<210>  4254
<211>  4136
<212>  DNA
<213>  Homo sapiens

<400>  4254
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gtcaaagaag attggaatgt cagaattacc aagctacgga   1920

agcaagtgga agagattttt aatttgaaat ttgctcaagc tcttggactc accgaggcag   1980

taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgtatgtg gaaggcttgc   2040

cagaggggat tcccttccga agccctacct ggtttggaat tccacgactt gaaaggatcg   2100

tccgcgggag taataaaatc aagttcgttg ttaaaaaacc tgaactagtt atttcctact   2160

tgcctcctgg gatggctagt aaaataaaca ctaaagcttt gcagtccccc aaaagaccac   2220

gaagtcctgg gagtaattca aaggttcctg aaattgaggt caccgtggaa ggccctaata   2280

acaacaatcc tcaaacctca gctgttcgaa ccccgaccca gactaacggt tctaacgttc   2340

ccttcaagcc acgagggaga gagttttcct ttgaggcctg gaatgccaaa atcacggacc   2400

taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg ggaagctctt ggccttaaac   2460

aagctgtgaa ggtgccgttc gcgttatttg agtctttccc ggaagacttt tatgtggaag   2520

gcttacctga gggtgtgcca ttccgaagac catcgacttt tggcattccg aggctggaga   2580

agatactcag aaacaaagcc aaaattaagt tcatcattaa aaagcccgaa atgtttgaga   2640

cggcgattaa ggagagcacc tcctctaaga gccctcccag aaaaataaat tcatcaccca   2700

atgttaatac tactgcatca ggtgttgaag accttaacat cattcaggtg acaattccag   2760

atgatgataa tgaaagactc tcgaaagttg aaaaagctag acagctaaga gaacaagtga   2820

atgacctctt tagtcggaaa tttggtgaag ctattggtat gggttttcct gtgaaagttc   2880

cctacaggaa aatcacaatt aaccctggct gtgtggtggt tgatggcatg cccccggggg   2940

tgtccttcaa agcccccagc tacctggaaa tcagctccat gagaaggatc ttagactctg   3000

ccgagtttat caaattcacg gtcattagac catttccagg acttgtgatt aataaccagc   3060

tggttgatca gagtgagtca gaaggccccg tgatacaaga atcagctgaa ccaagccagt   3120

tggaagttcc agccacagaa gaaataaaag agactgatgg aagctctcag atcaagcaag   3180

aaccagaccc cacgtggtag acctcttccc tcctaggctt aaagtatcag tggttgagaa   3240

gagcttttcg gacctgttac taccccaagc tgtagccttg agttacggtg tttattttcc   3300

aatcaagtga agatatctcc tacttctcct actggaacat ctcagcttct gcagtgaaga   3360

aaaattcctg tgatagttca gttctttagt ttttctattt gaaaaaaaaa aatcatttaa   3420

atgatccttt gttcacggct ctccttaatg actgagtgaa cagttcctat ctgtatattt   3480

gactaaacct tttcctaagc tatctctcat ggttcctatg tttttttatc ataattaaaa   3540

gcaaaaccat ctggatcacc taacagtcag aggtcagtat ctcagcgtgt gaattataga   3600

ggaaatacag agagaacctc ttccactttt acttttcgtc caaataaaat gcatggtgta   3660

ccagaagttg aagatcgggt tgaggattgg ggctagctcg atgacactaa ggccccaaca   3720

tcgcgggacc tgctgtggcg cggattctta ggaacgctgt tctagccggc cccctctcca   3780

ggggtcgccg tggccggcat tatttcctag ttcttcttgt aaccctgagg tgccagcgcg   3840

gggagtgagg aggggtcagg gggctaagga tgcaacctct gacgttctgc gccttcctag   3900

gagagtctta catgtgttga gatttcacaa gcaatgcgag ttgtaaaata ccagctctac   3960

aagaagctag gctctgtgac ggcatagttt tcagtagctt tatcacaata ttcacaatgg   4020

agaattatat gacatggtag cagaaatagg cccttttatg tgttgcttct attttacctc   4080

aaattgtaga tatagggtaa tcaataaaat ccatccatgc ctttcacaca ctaagt       4136


<210>  4255
<211>  932
<212>  PRT
<213>  Homo sapiens

<400>  4255

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
                485                 490                 495


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
            500                 505                 510


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
        515                 520                 525


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu 
    530                 535                 540


Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile 
545                 550                 555                 560


Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val 
                565                 570                 575


Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala 
            580                 585                 590


Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser 
        595                 600                 605


Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly 
    610                 615                 620


Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln 
625                 630                 635                 640


Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser 
                645                 650                 655


Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu 
            660                 665                 670


Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala 
        675                 680                 685


Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr 
    690                 695                 700


Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe 
705                 710                 715                 720


Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys 
                725                 730                 735


Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser 
            740                 745                 750


Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val 
        755                 760                 765


Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr 
    770                 775                 780


Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg 
785                 790                 795                 800


Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu 
                805                 810                 815


Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr 
            820                 825                 830


Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser 
        835                 840                 845


Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu 
    850                 855                 860


Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly 
865                 870                 875                 880


Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro 
                885                 890                 895


Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr 
            900                 905                 910


Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro 
        915                 920                 925


Asp Pro Thr Trp 
    930


<210>  4256
<211>  7276
<212>  DNA
<213>  Homo sapiens

<400>  4256
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2100

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2160

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2220

tgaatcaaac ccggagttct tgaaaggatc gtccgcggga gtaataaaat caagttcgtt   2280

gttaaaaaac ctgaactagt tatttcctac ttgcctcctg ggatggctag taaaataaac   2340

actaaagctt tgcagtcccc caaaagacca cgaagtcctg ggagtaattc aaaggttcct   2400

gaaattgagg tcaccgtgga aggccctaat aacaacaatc ctcaaacctc agctgttcga   2460

accccgaccc agactaacgg ttctaacgtt cccttcaagc cacgagggag agagttttcc   2520

tttgaggcct ggaatgccaa aatcacggac ctaaaacaga aagttgaaaa tctcttcaat   2580

gagaaatgtg gggaagctct tggccttaaa caagctgtga aggtgccgtt cgcgttattt   2640

gagtctttcc cggaagactt ttatgtggaa ggcttacctg agggtgtgcc attccgaaga   2700

ccatcgactt ttggcattcc gaggctggag aagatactca gaaacaaagc caaaattaag   2760

ttcatcatta aaaagcccga aatgtttgag acggcgatta aggagagcac ctcctctaag   2820

agccctccca gaaaaataaa ttcatcaccc aatgttaata ctactgcatc aggtgttgaa   2880

gaccttaaca tcattcaggt gacaattcca gatgatgata atgaaagact ctcgaaagtt   2940

gaaaaagcta gacagctaag agaacaagtg aatgacctct ttagtcggaa atttggtgaa   3000

gctattggta tgggttttcc tgtgaaagtt ccctacagga aaatcacaat taaccctggc   3060

tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca aagcccccag ctacctggaa   3120

atcagctcca tgagaaggat cttagactct gccgagttta tcaaattcac ggtcattagg   3180

taagtgagag tttcctgctt agtcacagga gcgaatctgg agctcatgag gctgactctt   3240

ctaaaatgca gccacaggta gtcatcgaat ccggcttcct atgctgtgca atcaacaaat   3300

caaaataact tgtgtcatca ttagaatgtc agatgtgctt ctacgaacta agctgactct   3360

tttaattctt tggcaaaggg ttggcaaact aggactgttt gccaaattca ggctgcctcc   3420

tatttttaga gtcttcctga aacacagcta cacccgtatt atccatggct gctttcctgt   3480

cacagtgagt aagtagctgg gactgagaag gcatggcctc caaagtctaa aatatttact   3540

ctctagcact ttgtagaaaa accttagcta ggcacagtgg ctaacgcctg taatcccagc   3600

attttgggag gccaaggcag gcagatcacc tgaggtcagg agttccagac cagcctggcc   3660

aacatggtga aatcccatct ctacaaaaat aaaacagtta gctgggcatg atggcgggtg   3720

cctgtaatcc cagctactcg ggaggctgag gcaggatagt cgcttgaacc caggaggtgg   3780

aggttgcaat gagccaagat catgccactg cactccagcc tggacgacag agtgagactc   3840

catcacaaga aaaaaagaac tttgtcaacc tctgtcttag ggcgccttgt cacaggcttc   3900

gggtcagacg gattcaacct tgcatcagcc atttgttagc caggtcactc tgttctttgt   3960

ctgtaaatga gattgatcgt tgttcccact gagagtgtca gctccttccc gtagagcagg   4020

catgatgatt gtactcacct ctgacaccat tgtgagtgcc acattccttc ccacgtcctt   4080

gtcactgtaa gagatgccca cctgagcacc aaccccaggt tatcttcccc tttgtcttcc   4140

agccccccag aaacagctac gactcaacct acccaatcat ttcatcatca gattgccact   4200

gtctctagtt caggtctctt gggactggca ctcagaaatc tcataataaa tcctcttgag   4260

gcttctcata cactcgtctt cttccaatct tctttccctc aaaatctcat attttggttc   4320

cacttcaccc accgtcattc tccatatcac tcccaggagt taggcaaaaa gccccttccg   4380

ttcttccgta tgttaaactt agaatcactc tgttccctgc tctgcgtttc tattttttgt   4440

ttttcctcca tttactagta gcttaacact ttctaacagt gttcttatta ttgatacgta   4500

tctatctctt ccataagctt ataaggtcac ggataatact tctcattgta gtacgtaaat   4560

gacgtgggct agatatgagt tgaataaaca gttatacctg taaattctta cagagtgaaa   4620

ataaattgtt atactttaca atttgtttct ctctttagac catttccagg acttgtgatt   4680

aataaccgtg agtattttgt gaagtgtttt gtttttgttt tttcctgggg tctgacgtgt   4740

gtgcgtgtga gtgtgtatac atgcttaacg tatatcacgt tacttcacct atgtcagtaa   4800

ccaggccaaa tacttgtttt agccctcagt aaaaacacca ggcacttcct agttgtaaaa   4860

ttattcaagc ttcttaactt cctatcctcg atgcacttaa tcataaaatg gtaataatag   4920

caccgatttt gggggagtcg ttccagtaga tggaaagcat ctggaacagg tgtcagcaag   4980

ctcctgccga cgtgtatgca taaagtttta ttgaaaccac catcgtgtcc atttgtttat   5040

ggcagaactg agagatggca gcagcaagtg tgtgcctgca aaacctaaaa tatttactaa   5100

ttggctctgc aagaaaagag tttgcatccc cctaacctag aacagtgtct agcctctagt   5160

atgtgtttag cctacagtat gtgctcagcg aatacaatct atatttatta ctgcttttat   5220

gactgttata attactgtgc ttggatttcg ttacaaagta agtcacaatg tgcctgcttc   5280

tgttagtatt tcagcacagt gcctggcaca catggggctc tcaaatattg ctgagcgagt   5340

gaacaaatgt cctttcaatt ccttaacgtt gatgtcattt tcaatagtat tttgagccaa   5400

acttaatttt gcgagtgtgt tttgttttct taactttatt attaaaaatg tataaaagtg   5460

aggccaggcg tggtggctca cgcctgtaat cccagcagtt tgggaggctg aggcaggcgg   5520

atcagttgag gttgggagtt ggagaccagc ccgtccaaca tggtgaaagc ctgtctctac   5580

taaaaataca aaaatcagct gggtgtggtg gcgcgtgcct gtaatcccag ctactcagga   5640

ggctgaggca ggagagttgc ttgaatccta gaggtggagg ttgcagtgag ctgagatcgt   5700

gccattgcac tccagcctgg gcaacaagag caaaactctg tcccaataaa taaataaata   5760

aaatgttctc ttttgttcct gttcttgtgc ggtagtgtgg tatagagttt tatggtaatt   5820

actgtgaatt agtgattctg agggacatat cagaactctg aggtttgttt ccttctcatc   5880

ttgagggaaa cagcaaatgt atgttaaaat gcttttccaa gggaacaaca catccttaca   5940

ttatttaaac caatctgctt cattttcaga gctggttgat cagagtgagt cagaaggccc   6000

cgtgatacaa gaatcagctg aaccaagcca gttggaagtt ccagccacag aagaaataaa   6060

agagactgat ggaagctctc agatcaagca agaaccagac cccacgtggt agacctcttc   6120

cctcctaggc ttaaagtatc agtggttgag aagagctttt cggacctgtt actaccccaa   6180

gctgtgtaat atacttgtat aacagaaata ccttctatac aaaccttttt ttctactttt   6240

agatagaaat gtctactttt tcagcagttc tgtgaattaa agagcagagt gactgtgggt   6300

ctggaatggc tggtgtactt gggaatgtac tatcaggatt ttacagcaat gctgggaaat   6360

gacagggaaa atgacaggaa tgaatctcac cagatttttt atgtactcag cagagccttg   6420

agttacggtg tttattttcc aatcaagtga agatatctcc tacttctcct actggaacat   6480

ctcagcttct gcagtgaaga aaaattcctg tgatagttca gttctttagt ttttctattt   6540

gaaaaaaaaa aatcatttaa atgatccttt gttcacggct ctccttaatg actgagtgaa   6600

cagttcctat ctgtatattt gactaaacct tttcctaagc tatctctcat ggttcctatg   6660

tttttttatc ataattaaaa gcaaaaccat ctggatcacc taacagtcag aggtcagtat   6720

ctcagcgtgt gaattataga ggaaatacag agagaacctc ttccactttt acttttcgtc   6780

caaataaaat gcatggtgta ccagaagttg aagatcgggt tgaggattgg ggctagctcg   6840

atgacactaa ggccccaaca tcgcgggacc tgctgtggcg cggattctta ggaacgctgt   6900

tctagccggc cccctctcca ggggtcgccg tggccggcat tatttcctag ttcttcttgt   6960

aaccctgagg tgccagcgcg gggagtgagg aggggtcagg gggctaagga tgcaacctct   7020

gacgttctgc gccttcctag gagagtctta catgtgttga gatttcacaa gcaatgcgag   7080

ttgtaaaata ccagctctac aagaagctag gctctgtgac ggcatagttt tcagtagctt   7140

tatcacaata ttcacaatgg agaattatat gacatggtag cagaaatagg cccttttatg   7200

tgttgcttct attttacctc aaattgtaga tatagggtaa tcaataaaat ccatccatgc   7260

ctttcacaca ctaagt                                                   7276


<210>  4257
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  4257

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys 
        595                 600                 605


Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu 
    610                 615                 620


Asn 
625


<210>  4258
<211>  8024
<212>  DNA
<213>  Homo sapiens

<400>  4258
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   1980

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2040

gaaatttgct tagatttgtt gacagcggtt tcctggagtg ctgtcttgag aacgattctg   2100

aggaggctca gcaagaaaga gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa   2160

ctcaagctct tggactcacc gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc   2220

cggagttctt gtatgtggaa ggcttgccag aggggattcc cttccgaagc cctacctggt   2280

ttggaattcc acgacttgaa aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta   2340

aaaaacctga actagttatt tcctacttgc ctcctgggat ggctagtaaa ataaacacta   2400

aagctttgca gtcccccaaa agaccacgaa gtcctgggag taattcaaag gttcctgaaa   2460

ttgaggtcac cgtggaaggc cctaataaca acaatcctca aacctcagct gttcgaaccc   2520

cgacccagac taacggttct aacgttccct tcaagccacg agggagagag ttttcctttg   2580

aggcctggaa tgccaaaatc acggacctaa aacagaaagt tgaaaatctc ttcaatgaga   2640

aatgtgggga agctcttggc cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt   2700

ctttcccgga agacttttat gtggaaggct tacctgaggg tgtgccattc cgaagaccat   2760

cgacttttgg cattccgagg ctggagaaga tactcagaaa caaagccaaa attaagttca   2820

tcattaaaaa gcccgaaatg tttgagacgg cgattaagga gagcacctcc tctaagagcc   2880

ctcccagaaa aataaattca tcacccaatg ttaatactac tgcatcaggt gttgaagacc   2940

ttaacatcat tcaggtgaca attccagatg atgataatga aagactctcg aaagttgaaa   3000

aagctagaca gctaagagaa caagtgaatg acctctttag tcggaaattt ggtgaagcta   3060

ttggtatggg ttttcctgtg aaagttccct acaggaaaat cacaattaac cctggctgtg   3120

tggtggttga tggcatgccc ccgggggtgt ccttcaaagc ccccagctac ctggaaatca   3180

gctccatgag aaggatctta gactctgccg agtttatcaa attcacggtc attaggtaag   3240

tgagagtttc ctgcttagtc acaggagcga atctggagct catgaggctg actcttctaa   3300

aatgcagcca caggtagtca tcgaatccgg cttcctatgc tgtgcaatca acaaatcaaa   3360

ataacttgtg tcatcattag aatgtcagat gtgcttctac gaactaagct gactctttta   3420

attctttggc aaagggttgg caaactagga ctgtttgcca aattcaggct gcctcctatt   3480

tttagagtct tcctgaaaca cagctacacc cgtattatcc atggctgctt tcctgtcaca   3540

gtgagtaagt agctgggact gagaaggcat ggcctccaaa gtctaaaata tttactctct   3600

agcactttgt agaaaaacct tagctaggca cagtggctaa cgcctgtaat cccagcattt   3660

tgggaggcca aggcaggcag atcacctgag gtcaggagtt ccagaccagc ctggccaaca   3720

tggtgaaatc ccatctctac aaaaataaaa cagttagctg ggcatgatgg cgggtgcctg   3780

taatcccagc tactcgggag gctgaggcag gatagtcgct tgaacccagg aggtggaggt   3840

tgcaatgagc caagatcatg ccactgcact ccagcctgga cgacagagtg agactccatc   3900

acaagaaaaa aagaactttg tcaacctctg tcttagggcg ccttgtcaca ggcttcgggt   3960

cagacggatt caaccttgca tcagccattt gttagccagg tcactctgtt ctttgtctgt   4020

aaatgagatt gatcgttgtt cccactgaga gtgtcagctc cttcccgtag agcaggcatg   4080

atgattgtac tcacctctga caccattgtg agtgccacat tccttcccac gtccttgtca   4140

ctgtaagaga tgcccacctg agcaccaacc ccaggttatc ttcccctttg tcttccagcc   4200

ccccagaaac agctacgact caacctaccc aatcatttca tcatcagatt gccactgtct   4260

ctagttcagg tctcttggga ctggcactca gaaatctcat aataaatcct cttgaggctt   4320

ctcatacact cgtcttcttc caatcttctt tccctcaaaa tctcatattt tggttccact   4380

tcacccaccg tcattctcca tatcactccc aggagttagg caaaaagccc cttccgttct   4440

tccgtatgtt aaacttagaa tcactctgtt ccctgctctg cgtttctatt ttttgttttt   4500

cctccattta ctagtagctt aacactttct aacagtgttc ttattattga tacgtatcta   4560

tctcttccat aagcttataa ggtcacggat aatacttctc attgtagtac gtaaatgacg   4620

tgggctagat atgagttgaa taaacagtta tacctgtaaa ttcttacaga gtgaaaataa   4680

attgttatac tttacaattt gtttctctct ttagaccatt tccaggactt gtgattaata   4740

accgtgagta ttttgtgaag tgttttgttt ttgttttttc ctggggtctg acgtgtgtgc   4800

gtgtgagtgt gtatacatgc ttaacgtata tcacgttact tcacctatgt cagtaaccag   4860

gccaaatact tgttttagcc ctcagtaaaa acaccaggca cttcctagtt gtaaaattat   4920

tcaagcttct taacttccta tcctcgatgc acttaatcat aaaatggtaa taatagcacc   4980

gattttgggg gagtcgttcc agtagatgga aagcatctgg aacaggtgtc agcaagctcc   5040

tgccgacgtg tatgcataaa gttttattga aaccaccatc gtgtccattt gtttatggca   5100

gaactgagag atggcagcag caagtgtgtg cctgcaaaac ctaaaatatt tactaattgg   5160

ctctgcaaga aaagagtttg catcccccta acctagaaca gtgtctagcc tctagtatgt   5220

gtttagccta cagtatgtgc tcagcgaata caatctatat ttattactgc ttttatgact   5280

gttataatta ctgtgcttgg atttcgttac aaagtaagtc acaatgtgcc tgcttctgtt   5340

agtatttcag cacagtgcct ggcacacatg gggctctcaa atattgctga gcgagtgaac   5400

aaatgtcctt tcaattcctt aacgttgatg tcattttcaa tagtattttg agccaaactt   5460

aattttgcga gtgtgttttg ttttcttaac tttattatta aaaatgtata aaagtgaggc   5520

caggcgtggt ggctcacgcc tgtaatccca gcagtttggg aggctgaggc aggcggatca   5580

gttgaggttg ggagttggag accagcccgt ccaacatggt gaaagcctgt ctctactaaa   5640

aatacaaaaa tcagctgggt gtggtggcgc gtgcctgtaa tcccagctac tcaggaggct   5700

gaggcaggag agttgcttga atcctagagg tggaggttgc agtgagctga gatcgtgcca   5760

ttgcactcca gcctgggcaa caagagcaaa actctgtccc aataaataaa taaataaaat   5820

gttctctttt gttcctgttc ttgtgcggta gtgtggtata gagttttatg gtaattactg   5880

tgaattagtg attctgaggg acatatcaga actctgaggt ttgtttcctt ctcatcttga   5940

gggaaacagc aaatgtatgt taaaatgctt ttccaaggga acaacacatc cttacattat   6000

ttaaaccaat ctgcttcatt ttcagagctg gttgatcaga gtgagtcaga aggccccgtg   6060

atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag   6120

actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc   6180

ctagggtaaa tcagcttctg tgtcagggat gctgtgtggt gtccatctga accccctgca   6240

tacgcgtagc taatgtgatc tccccacttt cacataagat ggtggccctg ccttcaggga   6300

atgtgggagc caggtgggag ccttcccgga tatttaagct agaagattct acagggagat   6360

tctccttgga tcaatatatg tctctcagtc aaagatgtaa aagcactttt gccttaaaaa   6420

gaatgttctg tttctaaata gagtcaacgt tgtcctcctc attggaattc actatgagtc   6480

agaatcatta gactgacttt tttttttcca tagtaatagt attttgcaga gtctcacaga   6540

gctgcagatc ttttgttcat cttgcagagt taacaagtct gatcctgtta gtccagattt   6600

cttaaatttg gccaagttat aataggagca gtagcttgag acccgaagtc aggaaacttt   6660

gacaatggat tttttttttt aatccagaga cttgtactgg aatttgcctt accctgtcag   6720

ctcatggact taaggtttca tcccgcttta tgagtgcttc tgaatccaag tcattgttac   6780

ctgaatttgc aaattaagtt gtgatattcg tgactgttaa attcctgtaa ttagattaac   6840

ctctttgctt gcttgtttgt tttctctcct attttagctt aaagtatcag tggttgagaa   6900

gagcttttcg gacctgttac taccccaagc tgtgtaatat acttgtataa cagaaatacc   6960

ttctatacaa accttttttt ctacttttag atagaaatgt ctactttttc agcagttctg   7020

tgaattaaag agcagagtga ctgtgggtct ggaatggctg gtgtacttgg gaatgtacta   7080

tcaggatttt acagcaatgc tgggaaatga cagggaaaat gacaggaatg aatctcacca   7140

gattttttat gtactcagca gagccttgag ttacggtgtt tattttccaa tcaagtgaag   7200

atatctccta cttctcctac tggaacatct cagcttctgc agtgaagaaa aattcctgtg   7260

atagttcagt tctttagttt ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt   7320

tcacggctct ccttaatgac tgagtgaaca gttcctatct gtatatttga ctaaaccttt   7380

tcctaagcta tctctcatgg ttcctatgtt tttttatcat aattaaaagc aaaaccatct   7440

ggatcaccta acagtcagag gtcagtatct cagcgtgtga attatagagg aaatacagag   7500

agaacctctt ccacttttac ttttcgtcca aataaaatgc atggtgtacc agaagttgaa   7560

gatcgggttg aggattgggg ctagctcgat gacactaagg ccccaacatc gcgggacctg   7620

ctgtggcgcg gattcttagg aacgctgttc tagccggccc cctctccagg ggtcgccgtg   7680

gccggcatta tttcctagtt cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag   7740

gggtcagggg gctaaggatg caacctctga cgttctgcgc cttcctagga gagtcttaca   7800

tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc agctctacaa gaagctaggc   7860

tctgtgacgg catagttttc agtagcttta tcacaatatt cacaatggag aattatatga   7920

catggtagca gaaataggcc cttttatgtg ttgcttctat tttacctcaa attgtagata   7980

tagggtaatc aataaaatcc atccatgcct ttcacacact aagt                    8024


<210>  4259
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  4259

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  4260
<211>  7721
<212>  DNA
<213>  Homo sapiens

<400>  4260
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagctc   1860

aagctcttgg actcaccgag gcagtaaaag taccatatcc tgtgtttgaa tcaaacccgg   1920

agttcttgta tgtggaaggc ttgccagagg ggattccctt ccgaagccct acctggtttg   1980

gaattccacg acttgaaagg atcgtccgcg ggagtaataa aatcaagttc gttgttaaaa   2040

aacctgaact agttatttcc tacttgcctc ctgggatggc tagtaaaata aacactaaag   2100

ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa ttcaaaggtt cctgaaattg   2160

aggtcaccgt ggaaggccct aataacaaca atcctcaaac ctcagctgtt cgaaccccga   2220

cccagactaa cggttctaac gttcccttca agccacgagg gagagagttt tcctttgagg   2280

cctggaatgc caaaatcacg gacctaaaac agaaagttga aaatctcttc aatgagaaat   2340

gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc gttcgcgtta tttgagtctt   2400

tcccggaaga cttttatgtg gaaggcttac ctgagggtgt gccattccga agaccatcga   2460

cttttggcat tccgaggctg gagaagatac tcagaaacaa agccaaaatt aagttcatca   2520

ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag cacctcctct aagagccctc   2580

ccagaaaaat aaattcatca cccaatgtta atactactgc atcaggtgtt gaagacctta   2640

acatcattca ggtgacaatt ccagatgatg ataatgaaag actctcgaaa gttgaaaaag   2700

ctagacagct aagagaacaa gtgaatgacc tctttagtcg gaaatttggt gaagctattg   2760

gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac aattaaccct ggctgtgtgg   2820

tggttgatgg catgcccccg ggggtgtcct tcaaagcccc cagctacctg gaaatcagct   2880

ccatgagaag gatcttagac tctgccgagt ttatcaaatt cacggtcatt aggtaagtga   2940

gagtttcctg cttagtcaca ggagcgaatc tggagctcat gaggctgact cttctaaaat   3000

gcagccacag gtagtcatcg aatccggctt cctatgctgt gcaatcaaca aatcaaaata   3060

acttgtgtca tcattagaat gtcagatgtg cttctacgaa ctaagctgac tcttttaatt   3120

ctttggcaaa gggttggcaa actaggactg tttgccaaat tcaggctgcc tcctattttt   3180

agagtcttcc tgaaacacag ctacacccgt attatccatg gctgctttcc tgtcacagtg   3240

agtaagtagc tgggactgag aaggcatggc ctccaaagtc taaaatattt actctctagc   3300

actttgtaga aaaaccttag ctaggcacag tggctaacgc ctgtaatccc agcattttgg   3360

gaggccaagg caggcagatc acctgaggtc aggagttcca gaccagcctg gccaacatgg   3420

tgaaatccca tctctacaaa aataaaacag ttagctgggc atgatggcgg gtgcctgtaa   3480

tcccagctac tcgggaggct gaggcaggat agtcgcttga acccaggagg tggaggttgc   3540

aatgagccaa gatcatgcca ctgcactcca gcctggacga cagagtgaga ctccatcaca   3600

agaaaaaaag aactttgtca acctctgtct tagggcgcct tgtcacaggc ttcgggtcag   3660

acggattcaa ccttgcatca gccatttgtt agccaggtca ctctgttctt tgtctgtaaa   3720

tgagattgat cgttgttccc actgagagtg tcagctcctt cccgtagagc aggcatgatg   3780

attgtactca cctctgacac cattgtgagt gccacattcc ttcccacgtc cttgtcactg   3840

taagagatgc ccacctgagc accaacccca ggttatcttc ccctttgtct tccagccccc   3900

cagaaacagc tacgactcaa cctacccaat catttcatca tcagattgcc actgtctcta   3960

gttcaggtct cttgggactg gcactcagaa atctcataat aaatcctctt gaggcttctc   4020

atacactcgt cttcttccaa tcttctttcc ctcaaaatct catattttgg ttccacttca   4080

cccaccgtca ttctccatat cactcccagg agttaggcaa aaagcccctt ccgttcttcc   4140

gtatgttaaa cttagaatca ctctgttccc tgctctgcgt ttctattttt tgtttttcct   4200

ccatttacta gtagcttaac actttctaac agtgttctta ttattgatac gtatctatct   4260

cttccataag cttataaggt cacggataat acttctcatt gtagtacgta aatgacgtgg   4320

gctagatatg agttgaataa acagttatac ctgtaaattc ttacagagtg aaaataaatt   4380

gttatacttt acaatttgtt tctctcttta gaccatttcc aggacttgtg attaataacc   4440

gtgagtattt tgtgaagtgt tttgtttttg ttttttcctg gggtctgacg tgtgtgcgtg   4500

tgagtgtgta tacatgctta acgtatatca cgttacttca cctatgtcag taaccaggcc   4560

aaatacttgt tttagccctc agtaaaaaca ccaggcactt cctagttgta aaattattca   4620

agcttcttaa cttcctatcc tcgatgcact taatcataaa atggtaataa tagcaccgat   4680

tttgggggag tcgttccagt agatggaaag catctggaac aggtgtcagc aagctcctgc   4740

cgacgtgtat gcataaagtt ttattgaaac caccatcgtg tccatttgtt tatggcagaa   4800

ctgagagatg gcagcagcaa gtgtgtgcct gcaaaaccta aaatatttac taattggctc   4860

tgcaagaaaa gagtttgcat ccccctaacc tagaacagtg tctagcctct agtatgtgtt   4920

tagcctacag tatgtgctca gcgaatacaa tctatattta ttactgcttt tatgactgtt   4980

ataattactg tgcttggatt tcgttacaaa gtaagtcaca atgtgcctgc ttctgttagt   5040

atttcagcac agtgcctggc acacatgggg ctctcaaata ttgctgagcg agtgaacaaa   5100

tgtcctttca attccttaac gttgatgtca ttttcaatag tattttgagc caaacttaat   5160

tttgcgagtg tgttttgttt tcttaacttt attattaaaa atgtataaaa gtgaggccag   5220

gcgtggtggc tcacgcctgt aatcccagca gtttgggagg ctgaggcagg cggatcagtt   5280

gaggttggga gttggagacc agcccgtcca acatggtgaa agcctgtctc tactaaaaat   5340

acaaaaatca gctgggtgtg gtggcgcgtg cctgtaatcc cagctactca ggaggctgag   5400

gcaggagagt tgcttgaatc ctagaggtgg aggttgcagt gagctgagat cgtgccattg   5460

cactccagcc tgggcaacaa gagcaaaact ctgtcccaat aaataaataa ataaaatgtt   5520

ctcttttgtt cctgttcttg tgcggtagtg tggtatagag ttttatggta attactgtga   5580

attagtgatt ctgagggaca tatcagaact ctgaggtttg tttccttctc atcttgaggg   5640

aaacagcaaa tgtatgttaa aatgcttttc caagggaaca acacatcctt acattattta   5700

aaccaatctg cttcattttc agagctggtt gatcagagtg agtcagaagg ccccgtgata   5760

caagaatcag ctgaaccaag ccagttggaa gttccagcca cagaagaaat aaaagagact   5820

gatggaagct ctcagatcaa gcaagaacca gaccccacgt ggtagacctc ttccctccta   5880

gggtaaatca gcttctgtgt cagggatgct gtgtggtgtc catctgaacc ccctgcatac   5940

gcgtagctaa tgtgatctcc ccactttcac ataagatggt ggccctgcct tcagggaatg   6000

tgggagccag gtgggagcct tcccggatat ttaagctaga agattctaca gggagattct   6060

ccttggatca atatatgtct ctcagtcaaa gatgtaaaag cacttttgcc ttaaaaagaa   6120

tgttctgttt ctaaatagag tcaacgttgt cctcctcatt ggaattcact atgagtcaga   6180

atcattagac tgactttttt ttttccatag taatagtatt ttgcagagtc tcacagagct   6240

gcagatcttt tgttcatctt gcagagttaa caagtctgat cctgttagtc cagatttctt   6300

aaatttggcc aagttataat aggagcagta gcttgagacc cgaagtcagg aaactttgac   6360

aatggatttt tttttttaat ccagagactt gtactggaat ttgccttacc ctgtcagctc   6420

atggacttaa ggtttcatcc cgctttatga gtgcttctga atccaagtca ttgttacctg   6480

aatttgcaaa ttaagttgtg atattcgtga ctgttaaatt cctgtaatta gattaacctc   6540

tttgcttgct tgtttgtttt ctctcctatt ttagcttaaa gtatcagtgg ttgagaagag   6600

cttttcggac ctgttactac cccaagctgt gtaatatact tgtataacag aaataccttc   6660

tatacaaacc tttttttcta cttttagata gaaatgtcta ctttttcagc agttctgtga   6720

attaaagagc agagtgactg tgggtctgga atggctggtg tacttgggaa tgtactatca   6780

ggattttaca gcaatgctgg gaaatgacag ggaaaatgac aggaatgaat ctcaccagat   6840

tttttatgta ctcagcagag ccttgagtta cggtgtttat tttccaatca agtgaagata   6900

tctcctactt ctcctactgg aacatctcag cttctgcagt gaagaaaaat tcctgtgata   6960

gttcagttct ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat cctttgttca   7020

cggctctcct taatgactga gtgaacagtt cctatctgta tatttgacta aaccttttcc   7080

taagctatct ctcatggttc ctatgttttt ttatcataat taaaagcaaa accatctgga   7140

tcacctaaca gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa tacagagaga   7200

acctcttcca cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga agttgaagat   7260

cgggttgagg attggggcta gctcgatgac actaaggccc caacatcgcg ggacctgctg   7320

tggcgcggat tcttaggaac gctgttctag ccggccccct ctccaggggt cgccgtggcc   7380

ggcattattt cctagttctt cttgtaaccc tgaggtgcca gcgcggggag tgaggagggg   7440

tcagggggct aaggatgcaa cctctgacgt tctgcgcctt cctaggagag tcttacatgt   7500

gttgagattt cacaagcaat gcgagttgta aaataccagc tctacaagaa gctaggctct   7560

gtgacggcat agttttcagt agctttatca caatattcac aatggagaat tatatgacat   7620

ggtagcagaa ataggccctt ttatgtgttg cttctatttt acctcaaatt gtagatatag   7680

ggtaatcaat aaaatccatc catgcctttc acacactaag t                       7721


<210>  4261
<211>  783
<212>  PRT
<213>  Homo sapiens

<400>  4261

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu 
            420                 425                 430


Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu 
        435                 440                 445


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp 
    450                 455                 460


Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile 
465                 470                 475                 480


Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro 
                485                 490                 495


Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg 
            500                 505                 510


Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr 
        515                 520                 525


Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr 
    530                 535                 540


Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg 
545                 550                 555                 560


Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln 
                565                 570                 575


Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu 
            580                 585                 590


Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu 
        595                 600                 605


Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro 
    610                 615                 620


Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala 
625                 630                 635                 640


Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile 
                645                 650                 655


Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser 
            660                 665                 670


Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile 
        675                 680                 685


Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu 
    690                 695                 700


Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys 
705                 710                 715                 720


Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg 
                725                 730                 735


Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro 
            740                 745                 750


Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg 
        755                 760                 765


Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
    770                 775                 780


<210>  4262
<211>  4291
<212>  DNA
<213>  Homo sapiens

<400>  4262
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   2040

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2100

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2160

atcaaacccg gagttcttgt atgtggaagg cttgccagag gggattccct tccgaagccc   2220

tacctggttt ggaattccac gacttgaaag gatcgtccgc gggagtaata aaatcaagtt   2280

cgttgttaaa aaacctgaac tagttatttc ctacttgcct cctgggatgg ctagtaaaat   2340

aaacactaaa gctttgcagt cccccaaaag accacgaagt cctgggagta attcaaaggt   2400

tcctgaaatt gaggtcaccg tggaaggccc taataacaac aatcctcaaa cctcagctgt   2460

tcgaaccccg acccagacta acggttctaa cgttcccttc aagccacgag ggagagagtt   2520

ttcctttgag gcctggaatg ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt   2580

caatgagaaa tgtggggaag ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt   2640

atttgagtct ttcccggaag acttttatgt ggaaggctta cctgagggtg tgccattccg   2700

aagaccatcg acttttggca ttccgaggct ggagaagata ctcagaaaca aagccaaaat   2760

taagttcatc attaaaaagc ccgaaatgtt tgagacggcg attaaggaga gcacctcctc   2820

taagagccct cccagaaaaa taaattcatc acccaatgtt aatactactg catcaggtgt   2880

tgaagacctt aacatcattc aggtgacaat tccagatgat gataatgaaa gactctcgaa   2940

agttgaaaaa gctagacagc taagagaaca agtgaatgac ctctttagtc ggaaatttgg   3000

tgaagctatt ggtatgggtt ttcctgtgaa agttccctac aggaaaatca caattaaccc   3060

tggctgtgtg gtggttgatg gcatgccccc gggggtgtcc ttcaaagccc ccagctacct   3120

ggaaatcagc tccatgagaa ggatcttaga ctctgccgag tttatcaaat tcacggtcat   3180

tagaccattt ccaggacttg tgattaataa ccagctggtt gatcagagtg agtcagaagg   3240

ccccgtgata caagaatcag ctgaaccaag ccagttggaa gttccagcca cagaagaaat   3300

aaaagagact gatggaagct ctcagatcaa gcaagaacca gaccccacgt ggtagacctc   3360

ttccctccta ggcttaaagt atcagtggtt gagaagagct tttcggacct gttactaccc   3420

caagctgtag ccttgagtta cggtgtttat tttccaatca agtgaagata tctcctactt   3480

ctcctactgg aacatctcag cttctgcagt gaagaaaaat tcctgtgata gttcagttct   3540

ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat cctttgttca cggctctcct   3600

taatgactga gtgaacagtt cctatctgta tatttgacta aaccttttcc taagctatct   3660

ctcatggttc ctatgttttt ttatcataat taaaagcaaa accatctgga tcacctaaca   3720

gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa tacagagaga acctcttcca   3780

cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga agttgaagat cgggttgagg   3840

attggggcta gctcgatgac actaaggccc caacatcgcg ggacctgctg tggcgcggat   3900

tcttaggaac gctgttctag ccggccccct ctccaggggt cgccgtggcc ggcattattt   3960

cctagttctt cttgtaaccc tgaggtgcca gcgcggggag tgaggagggg tcagggggct   4020

aaggatgcaa cctctgacgt tctgcgcctt cctaggagag tcttacatgt gttgagattt   4080

cacaagcaat gcgagttgta aaataccagc tctacaagaa gctaggctct gtgacggcat   4140

agttttcagt agctttatca caatattcac aatggagaat tatatgacat ggtagcagaa   4200

ataggccctt ttatgtgttg cttctatttt acctcaaatt gtagatatag ggtaatcaat   4260

aaaatccatc catgcctttc acacactaag t                                  4291


<210>  4263
<211>  977
<212>  PRT
<213>  Homo sapiens

<400>  4263

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
                565                 570                 575


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
            580                 585                 590


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
        595                 600                 605


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
    610                 615                 620


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
625                 630                 635                 640


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
                645                 650                 655


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
            660                 665                 670


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
        675                 680                 685


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
    690                 695                 700


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
705                 710                 715                 720


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
                725                 730                 735


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
            740                 745                 750


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
        755                 760                 765


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
    770                 775                 780


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
785                 790                 795                 800


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
                805                 810                 815


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
            820                 825                 830


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
        835                 840                 845


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
    850                 855                 860


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
865                 870                 875                 880


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
                885                 890                 895


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
            900                 905                 910


Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile 
        915                 920                 925


Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln 
    930                 935                 940


Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile 
945                 950                 955                 960


Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr 
                965                 970                 975


Trp 



<210>  4264
<211>  4160
<212>  DNA
<213>  Homo sapiens

<400>  4264
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gtcaaagaag attggaatgt   1980

cagaattacc aagctacgga agcaagtgga agagattttt aatttgaaat ttgctcaagc   2040

tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt   2100

cttgtatgtg gaaggcttgc cagaggggat tcccttccga agccctacct ggtttggaat   2160

tccacgactt gaaaggatcg tccgcgggag taataaaatc aagttcgttg ttaaaaaacc   2220

tgaactagtt atttcctact tgcctcctgg gatggctagt aaaataaaca ctaaagcttt   2280

gcagtccccc aaaagaccac gaagtcctgg gagtaattca aaggttcctg aaattgaggt   2340

caccgtggaa ggccctaata acaacaatcc tcaaacctca gctgttcgaa ccccgaccca   2400

gactaacggt tctaacgttc ccttcaagcc acgagggaga gagttttcct ttgaggcctg   2460

gaatgccaaa atcacggacc taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg   2520

ggaagctctt ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg agtctttccc   2580

ggaagacttt tatgtggaag gcttacctga gggtgtgcca ttccgaagac catcgacttt   2640

tggcattccg aggctggaga agatactcag aaacaaagcc aaaattaagt tcatcattaa   2700

aaagcccgaa atgtttgaga cggcgattaa ggagagcacc tcctctaaga gccctcccag   2760

aaaaataaat tcatcaccca atgttaatac tactgcatca ggtgttgaag accttaacat   2820

cattcaggtg acaattccag atgatgataa tgaaagactc tcgaaagttg aaaaagctag   2880

acagctaaga gaacaagtga atgacctctt tagtcggaaa tttggtgaag ctattggtat   2940

gggttttcct gtgaaagttc cctacaggaa aatcacaatt aaccctggct gtgtggtggt   3000

tgatggcatg cccccggggg tgtccttcaa agcccccagc tacctggaaa tcagctccat   3060

gagaaggatc ttagactctg ccgagtttat caaattcacg gtcattagac catttccagg   3120

acttgtgatt aataaccagc tggttgatca gagtgagtca gaaggccccg tgatacaaga   3180

atcagctgaa ccaagccagt tggaagttcc agccacagaa gaaataaaag agactgatgg   3240

aagctctcag atcaagcaag aaccagaccc cacgtggtag acctcttccc tcctaggagc   3300

cttgagttac ggtgtttatt ttccaatcaa gtgaagatat ctcctacttc tcctactgga   3360

acatctcagc ttctgcagtg aagaaaaatt cctgtgatag ttcagttctt tagtttttct   3420

atttgaaaaa aaaaaatcat ttaaatgatc ctttgttcac ggctctcctt aatgactgag   3480

tgaacagttc ctatctgtat atttgactaa accttttcct aagctatctc tcatggttcc   3540

tatgtttttt tatcataatt aaaagcaaaa ccatctggat cacctaacag tcagaggtca   3600

gtatctcagc gtgtgaatta tagaggaaat acagagagaa cctcttccac ttttactttt   3660

cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc gggttgagga ttggggctag   3720

ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg   3780

ctgttctagc cggccccctc tccaggggtc gccgtggccg gcattatttc ctagttcttc   3840

ttgtaaccct gaggtgccag cgcggggagt gaggaggggt cagggggcta aggatgcaac   3900

ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg ttgagatttc acaagcaatg   3960

cgagttgtaa aataccagct ctacaagaag ctaggctctg tgacggcata gttttcagta   4020

gctttatcac aatattcaca atggagaatt atatgacatg gtagcagaaa taggcccttt   4080

tatgtgttgc ttctatttta cctcaaattg tagatatagg gtaatcaata aaatccatcc   4140

atgcctttca cacactaagt                                               4160


<210>  4265
<211>  952
<212>  PRT
<213>  Homo sapiens

<400>  4265

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr 
                565                 570                 575


Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys 
            580                 585                 590


Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro 
        595                 600                 605


Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys 
    610                 615                 620


Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val 
625                 630                 635                 640


Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg 
                645                 650                 655


Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly 
            660                 665                 670


Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys 
        675                 680                 685


Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly 
    690                 695                 700


Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro 
705                 710                 715                 720


Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg 
                725                 730                 735


Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys 
            740                 745                 750


Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala 
        755                 760                 765


Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser 
    770                 775                 780


Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile 
785                 790                 795                 800


Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val 
                805                 810                 815


Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg 
            820                 825                 830


Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr 
        835                 840                 845


Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro 
    850                 855                 860


Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met 
865                 870                 875                 880


Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
                885                 890                 895


Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu 
            900                 905                 910


Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu 
        915                 920                 925


Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile 
    930                 935                 940


Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  4266
<211>  7351
<212>  DNA
<213>  Homo sapiens

<400>  4266
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   2040

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   2100

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2160

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2220

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2280

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2340

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2400

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2460

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2520

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2580

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2640

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2700

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2760

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2820

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2880

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2940

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   3000

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   3060

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3120

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3180

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3240

ttcacggtca ttaggtaagt gagagtttcc tgcttagtca caggagcgaa tctggagctc   3300

atgaggctga ctcttctaaa atgcagccac aggtagtcat cgaatccggc ttcctatgct   3360

gtgcaatcaa caaatcaaaa taacttgtgt catcattaga atgtcagatg tgcttctacg   3420

aactaagctg actcttttaa ttctttggca aagggttggc aaactaggac tgtttgccaa   3480

attcaggctg cctcctattt ttagagtctt cctgaaacac agctacaccc gtattatcca   3540

tggctgcttt cctgtcacag tgagtaagta gctgggactg agaaggcatg gcctccaaag   3600

tctaaaatat ttactctcta gcactttgta gaaaaacctt agctaggcac agtggctaac   3660

gcctgtaatc ccagcatttt gggaggccaa ggcaggcaga tcacctgagg tcaggagttc   3720

cagaccagcc tggccaacat ggtgaaatcc catctctaca aaaataaaac agttagctgg   3780

gcatgatggc gggtgcctgt aatcccagct actcgggagg ctgaggcagg atagtcgctt   3840

gaacccagga ggtggaggtt gcaatgagcc aagatcatgc cactgcactc cagcctggac   3900

gacagagtga gactccatca caagaaaaaa agaactttgt caacctctgt cttagggcgc   3960

cttgtcacag gcttcgggtc agacggattc aaccttgcat cagccatttg ttagccaggt   4020

cactctgttc tttgtctgta aatgagattg atcgttgttc ccactgagag tgtcagctcc   4080

ttcccgtaga gcaggcatga tgattgtact cacctctgac accattgtga gtgccacatt   4140

ccttcccacg tccttgtcac tgtaagagat gcccacctga gcaccaaccc caggttatct   4200

tcccctttgt cttccagccc cccagaaaca gctacgactc aacctaccca atcatttcat   4260

catcagattg ccactgtctc tagttcaggt ctcttgggac tggcactcag aaatctcata   4320

ataaatcctc ttgaggcttc tcatacactc gtcttcttcc aatcttcttt ccctcaaaat   4380

ctcatatttt ggttccactt cacccaccgt cattctccat atcactccca ggagttaggc   4440

aaaaagcccc ttccgttctt ccgtatgtta aacttagaat cactctgttc cctgctctgc   4500

gtttctattt tttgtttttc ctccatttac tagtagctta acactttcta acagtgttct   4560

tattattgat acgtatctat ctcttccata agcttataag gtcacggata atacttctca   4620

ttgtagtacg taaatgacgt gggctagata tgagttgaat aaacagttat acctgtaaat   4680

tcttacagag tgaaaataaa ttgttatact ttacaatttg tttctctctt tagaccattt   4740

ccaggacttg tgattaataa ccgtgagtat tttgtgaagt gttttgtttt tgttttttcc   4800

tggggtctga cgtgtgtgcg tgtgagtgtg tatacatgct taacgtatat cacgttactt   4860

cacctatgtc agtaaccagg ccaaatactt gttttagccc tcagtaaaaa caccaggcac   4920

ttcctagttg taaaattatt caagcttctt aacttcctat cctcgatgca cttaatcata   4980

aaatggtaat aatagcaccg attttggggg agtcgttcca gtagatggaa agcatctgga   5040

acaggtgtca gcaagctcct gccgacgtgt atgcataaag ttttattgaa accaccatcg   5100

tgtccatttg tttatggcag aactgagaga tggcagcagc aagtgtgtgc ctgcaaaacc   5160

taaaatattt actaattggc tctgcaagaa aagagtttgc atccccctaa cctagaacag   5220

tgtctagcct ctagtatgtg tttagcctac agtatgtgct cagcgaatac aatctatatt   5280

tattactgct tttatgactg ttataattac tgtgcttgga tttcgttaca aagtaagtca   5340

caatgtgcct gcttctgtta gtatttcagc acagtgcctg gcacacatgg ggctctcaaa   5400

tattgctgag cgagtgaaca aatgtccttt caattcctta acgttgatgt cattttcaat   5460

agtattttga gccaaactta attttgcgag tgtgttttgt tttcttaact ttattattaa   5520

aaatgtataa aagtgaggcc aggcgtggtg gctcacgcct gtaatcccag cagtttggga   5580

ggctgaggca ggcggatcag ttgaggttgg gagttggaga ccagcccgtc caacatggtg   5640

aaagcctgtc tctactaaaa atacaaaaat cagctgggtg tggtggcgcg tgcctgtaat   5700

cccagctact caggaggctg aggcaggaga gttgcttgaa tcctagaggt ggaggttgca   5760

gtgagctgag atcgtgccat tgcactccag cctgggcaac aagagcaaaa ctctgtccca   5820

ataaataaat aaataaaatg ttctcttttg ttcctgttct tgtgcggtag tgtggtatag   5880

agttttatgg taattactgt gaattagtga ttctgaggga catatcagaa ctctgaggtt   5940

tgtttccttc tcatcttgag ggaaacagca aatgtatgtt aaaatgcttt tccaagggaa   6000

caacacatcc ttacattatt taaaccaatc tgcttcattt tcagagctgg ttgatcagag   6060

tgagtcagaa ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc   6120

cacagaagaa ataaaagaga ctgatggaag ctctcagatc aagcaagaac cagaccccac   6180

gtggtagacc tcttccctcc taggcttaaa gtatcagtgg ttgagaagag cttttcggac   6240

ctgttactac cccaagctgt gtaatatact tgtataacag aaataccttc tatacaaacc   6300

tttttttcta cttttagata gaaatgtcta ctttttcagc agttctgtga attaaagagc   6360

agagtgactg tgggtctgga atggctggtg tacttgggaa tgtactatca ggattttaca   6420

gcaatgctgg gaaatgacag ggaaaatgac aggaatgaat ctcaccagat tttttatgta   6480

ctcagcagag ccttgagtta cggtgtttat tttccaatca agtgaagata tctcctactt   6540

ctcctactgg aacatctcag cttctgcagt gaagaaaaat tcctgtgata gttcagttct   6600

ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat cctttgttca cggctctcct   6660

taatgactga gtgaacagtt cctatctgta tatttgacta aaccttttcc taagctatct   6720

ctcatggttc ctatgttttt ttatcataat taaaagcaaa accatctgga tcacctaaca   6780

gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa tacagagaga acctcttcca   6840

cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga agttgaagat cgggttgagg   6900

attggggcta gctcgatgac actaaggccc caacatcgcg ggacctgctg tggcgcggat   6960

tcttaggaac gctgttctag ccggccccct ctccaggggt cgccgtggcc ggcattattt   7020

cctagttctt cttgtaaccc tgaggtgcca gcgcggggag tgaggagggg tcagggggct   7080

aaggatgcaa cctctgacgt tctgcgcctt cctaggagag tcttacatgt gttgagattt   7140

cacaagcaat gcgagttgta aaataccagc tctacaagaa gctaggctct gtgacggcat   7200

agttttcagt agctttatca caatattcac aatggagaat tatatgacat ggtagcagaa   7260

ataggccctt ttatgtgttg cttctatttt acctcaaatt gtagatatag ggtaatcaat   7320

aaaatccatc catgcctttc acacactaag t                                  7351


<210>  4267
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  4267

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
465                 470                 475                 480


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
                485                 490                 495


<210>  4268
<211>  7291
<212>  DNA
<213>  Homo sapiens

<400>  4268
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   2040

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2100

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2160

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2220

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2280

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2340

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2400

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2460

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2520

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2580

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2640

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2700

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2760

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2820

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2880

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   2940

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   3000

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3060

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3120

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3180

ttcacggtca ttaggtaagt gagagtttcc tgcttagtca caggagcgaa tctggagctc   3240

atgaggctga ctcttctaaa atgcagccac aggtagtcat cgaatccggc ttcctatgct   3300

gtgcaatcaa caaatcaaaa taacttgtgt catcattaga atgtcagatg tgcttctacg   3360

aactaagctg actcttttaa ttctttggca aagggttggc aaactaggac tgtttgccaa   3420

attcaggctg cctcctattt ttagagtctt cctgaaacac agctacaccc gtattatcca   3480

tggctgcttt cctgtcacag tgagtaagta gctgggactg agaaggcatg gcctccaaag   3540

tctaaaatat ttactctcta gcactttgta gaaaaacctt agctaggcac agtggctaac   3600

gcctgtaatc ccagcatttt gggaggccaa ggcaggcaga tcacctgagg tcaggagttc   3660

cagaccagcc tggccaacat ggtgaaatcc catctctaca aaaataaaac agttagctgg   3720

gcatgatggc gggtgcctgt aatcccagct actcgggagg ctgaggcagg atagtcgctt   3780

gaacccagga ggtggaggtt gcaatgagcc aagatcatgc cactgcactc cagcctggac   3840

gacagagtga gactccatca caagaaaaaa agaactttgt caacctctgt cttagggcgc   3900

cttgtcacag gcttcgggtc agacggattc aaccttgcat cagccatttg ttagccaggt   3960

cactctgttc tttgtctgta aatgagattg atcgttgttc ccactgagag tgtcagctcc   4020

ttcccgtaga gcaggcatga tgattgtact cacctctgac accattgtga gtgccacatt   4080

ccttcccacg tccttgtcac tgtaagagat gcccacctga gcaccaaccc caggttatct   4140

tcccctttgt cttccagccc cccagaaaca gctacgactc aacctaccca atcatttcat   4200

catcagattg ccactgtctc tagttcaggt ctcttgggac tggcactcag aaatctcata   4260

ataaatcctc ttgaggcttc tcatacactc gtcttcttcc aatcttcttt ccctcaaaat   4320

ctcatatttt ggttccactt cacccaccgt cattctccat atcactccca ggagttaggc   4380

aaaaagcccc ttccgttctt ccgtatgtta aacttagaat cactctgttc cctgctctgc   4440

gtttctattt tttgtttttc ctccatttac tagtagctta acactttcta acagtgttct   4500

tattattgat acgtatctat ctcttccata agcttataag gtcacggata atacttctca   4560

ttgtagtacg taaatgacgt gggctagata tgagttgaat aaacagttat acctgtaaat   4620

tcttacagag tgaaaataaa ttgttatact ttacaatttg tttctctctt tagaccattt   4680

ccaggacttg tgattaataa ccgtgagtat tttgtgaagt gttttgtttt tgttttttcc   4740

tggggtctga cgtgtgtgcg tgtgagtgtg tatacatgct taacgtatat cacgttactt   4800

cacctatgtc agtaaccagg ccaaatactt gttttagccc tcagtaaaaa caccaggcac   4860

ttcctagttg taaaattatt caagcttctt aacttcctat cctcgatgca cttaatcata   4920

aaatggtaat aatagcaccg attttggggg agtcgttcca gtagatggaa agcatctgga   4980

acaggtgtca gcaagctcct gccgacgtgt atgcataaag ttttattgaa accaccatcg   5040

tgtccatttg tttatggcag aactgagaga tggcagcagc aagtgtgtgc ctgcaaaacc   5100

taaaatattt actaattggc tctgcaagaa aagagtttgc atccccctaa cctagaacag   5160

tgtctagcct ctagtatgtg tttagcctac agtatgtgct cagcgaatac aatctatatt   5220

tattactgct tttatgactg ttataattac tgtgcttgga tttcgttaca aagtaagtca   5280

caatgtgcct gcttctgtta gtatttcagc acagtgcctg gcacacatgg ggctctcaaa   5340

tattgctgag cgagtgaaca aatgtccttt caattcctta acgttgatgt cattttcaat   5400

agtattttga gccaaactta attttgcgag tgtgttttgt tttcttaact ttattattaa   5460

aaatgtataa aagtgaggcc aggcgtggtg gctcacgcct gtaatcccag cagtttggga   5520

ggctgaggca ggcggatcag ttgaggttgg gagttggaga ccagcccgtc caacatggtg   5580

aaagcctgtc tctactaaaa atacaaaaat cagctgggtg tggtggcgcg tgcctgtaat   5640

cccagctact caggaggctg aggcaggaga gttgcttgaa tcctagaggt ggaggttgca   5700

gtgagctgag atcgtgccat tgcactccag cctgggcaac aagagcaaaa ctctgtccca   5760

ataaataaat aaataaaatg ttctcttttg ttcctgttct tgtgcggtag tgtggtatag   5820

agttttatgg taattactgt gaattagtga ttctgaggga catatcagaa ctctgaggtt   5880

tgtttccttc tcatcttgag ggaaacagca aatgtatgtt aaaatgcttt tccaagggaa   5940

caacacatcc ttacattatt taaaccaatc tgcttcattt tcagagctgg ttgatcagag   6000

tgagtcagaa ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc   6060

cacagaagaa ataaaagaga ctgatggaag ctctcagatc aagcaagaac cagaccccac   6120

gtggtagacc tcttccctcc taggcttaaa gtatcagtgg ttgagaagag cttttcggac   6180

ctgttactac cccaagctgt gtaatatact tgtataacag aaataccttc tatacaaacc   6240

tttttttcta cttttagata gaaatgtcta ctttttcagc agttctgtga attaaagagc   6300

agagtgactg tgggtctgga atggctggtg tacttgggaa tgtactatca ggattttaca   6360

gcaatgctgg gaaatgacag ggaaaatgac aggaatgaat ctcaccagat tttttatgta   6420

ctcagcagag ccttgagtta cggtgtttat tttccaatca agtgaagata tctcctactt   6480

ctcctactgg aacatctcag cttctgcagt gaagaaaaat tcctgtgata gttcagttct   6540

ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat cctttgttca cggctctcct   6600

taatgactga gtgaacagtt cctatctgta tatttgacta aaccttttcc taagctatct   6660

ctcatggttc ctatgttttt ttatcataat taaaagcaaa accatctgga tcacctaaca   6720

gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa tacagagaga acctcttcca   6780

cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga agttgaagat cgggttgagg   6840

attggggcta gctcgatgac actaaggccc caacatcgcg ggacctgctg tggcgcggat   6900

tcttaggaac gctgttctag ccggccccct ctccaggggt cgccgtggcc ggcattattt   6960

cctagttctt cttgtaaccc tgaggtgcca gcgcggggag tgaggagggg tcagggggct   7020

aaggatgcaa cctctgacgt tctgcgcctt cctaggagag tcttacatgt gttgagattt   7080

cacaagcaat gcgagttgta aaataccagc tctacaagaa gctaggctct gtgacggcat   7140

agttttcagt agctttatca caatattcac aatggagaat tatatgacat ggtagcagaa   7200

ataggccctt ttatgtgttg cttctatttt acctcaaatt gtagatatag ggtaatcaat   7260

aaaatccatc catgcctttc acacactaag t                                  7291


<210>  4269
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  4269

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
    450                 455                 460


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
465                 470                 475


<210>  4270
<211>  5194
<212>  DNA
<213>  Homo sapiens

<400>  4270
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   2040

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2100

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2160

tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg tttggaattc   2220

cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg   2280

aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc   2340

agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca   2400

ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga   2460

ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga   2520

atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg   2580

aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg   2640

aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg   2700

gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa   2760

agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa   2820

aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca   2880

ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac   2940

agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg   3000

gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg   3060

atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga   3120

gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca tttccaggac   3180

ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat   3240

cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa   3300

gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc ctagggtaaa   3360

tcagcttctg tgtcagggat gctgtgtggt gtccatctga accccctgca tacgcgtagc   3420

taatgtgatc tccccacttt cacataagat ggtggccctg ccttcaggga atgtgggagc   3480

caggtgggag ccttcccgga tatttaagct agaagattct acagggagat tctccttgga   3540

tcaatatatg tctctcagtc aaagatgtaa aagcactttt gccttaaaaa gaatgttctg   3600

tttctaaata gagtcaacgt tgtcctcctc attggaattc actatgagtc agaatcatta   3660

gactgacttt tttttttcca tagtaatagt attttgcaga gtctcacaga gctgcagatc   3720

ttttgttcat cttgcagagt taacaagtct gatcctgtta gtccagattt cttaaatttg   3780

gccaagttat aataggagca gtagcttgag acccgaagtc aggaaacttt gacaatggat   3840

tttttttttt aatccagaga cttgtactgg aatttgcctt accctgtcag ctcatggact   3900

taaggtttca tcccgcttta tgagtgcttc tgaatccaag tcattgttac ctgaatttgc   3960

aaattaagtt gtgatattcg tgactgttaa attcctgtaa ttagattaac ctctttgctt   4020

gcttgtttgt tttctctcct attttagctt aaagtatcag tggttgagaa gagcttttcg   4080

gacctgttac taccccaagc tgtgtaatat acttgtataa cagaaatacc ttctatacaa   4140

accttttttt ctacttttag atagaaatgt ctactttttc agcagttctg tgaattaaag   4200

agcagagtga ctgtgggtct ggaatggctg gtgtacttgg gaatgtacta tcaggatttt   4260

acagcaatgc tgggaaatga cagggaaaat gacaggaatg aatctcacca gattttttat   4320

gtactcagca gagccttgag ttacggtgtt tattttccaa tcaagtgaag atatctccta   4380

cttctcctac tggaacatct cagcttctgc agtgaagaaa aattcctgtg atagttcagt   4440

tctttagttt ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt tcacggctct   4500

ccttaatgac tgagtgaaca gttcctatct gtatatttga ctaaaccttt tcctaagcta   4560

tctctcatgg ttcctatgtt tttttatcat aattaaaagc aaaaccatct ggatcaccta   4620

acagtcagag gtcagtatct cagcgtgtga attatagagg aaatacagag agaacctctt   4680

ccacttttac ttttcgtcca aataaaatgc atggtgtacc agaagttgaa gatcgggttg   4740

aggattgggg ctagctcgat gacactaagg ccccaacatc gcgggacctg ctgtggcgcg   4800

gattcttagg aacgctgttc tagccggccc cctctccagg ggtcgccgtg gccggcatta   4860

tttcctagtt cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg   4920

gctaaggatg caacctctga cgttctgcgc cttcctagga gagtcttaca tgtgttgaga   4980

tttcacaagc aatgcgagtt gtaaaatacc agctctacaa gaagctaggc tctgtgacgg   5040

catagttttc agtagcttta tcacaatatt cacaatggag aattatatga catggtagca   5100

gaaataggcc cttttatgtg ttgcttctat tttacctcaa attgtagata tagggtaatc   5160

aataaaatcc atccatgcct ttcacacact aagt                               5194


<210>  4271
<211>  978
<212>  PRT
<213>  Homo sapiens

<400>  4271

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu 
            580                 585                 590


Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg 
        595                 600                 605


Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys 
    610                 615                 620


Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys 
625                 630                 635                 640


Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly 
                645                 650                 655


Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn 
            660                 665                 670


Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn 
        675                 680                 685


Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu 
    690                 695                 700


Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu 
705                 710                 715                 720


Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys 
                725                 730                 735


Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu 
            740                 745                 750


Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile 
        755                 760                 765


Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile 
    770                 775                 780


Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser 
785                 790                 795                 800


Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr 
                805                 810                 815


Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro 
            820                 825                 830


Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu 
        835                 840                 845


Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile 
    850                 855                 860


Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn 
865                 870                 875                 880


Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys 
                885                 890                 895


Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser 
            900                 905                 910


Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val 
        915                 920                 925


Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile 
    930                 935                 940


Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu 
945                 950                 955                 960


Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro 
                965                 970                 975


Thr Trp 



<210>  4272
<211>  5274
<212>  DNA
<213>  Homo sapiens

<400>  4272
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2100

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2160

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2220

tgaatcaaac ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag   2280

ccctacctgg tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa   2340

gttcgttgtt aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa   2400

aataaacact aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa   2460

ggttcctgaa attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc   2520

tgttcgaacc ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga   2580

gttttccttt gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct   2640

cttcaatgag aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc   2700

gttatttgag tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt   2760

ccgaagacca tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa   2820

aattaagttc atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc   2880

ctctaagagc cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg   2940

tgttgaagac cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc   3000

gaaagttgaa aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt   3060

tggtgaagct attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa   3120

ccctggctgt gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta   3180

cctggaaatc agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt   3240

cattagacca tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga   3300

aggccccgtg atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga   3360

aataaaagag actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac   3420

ctcttccctc ctagggtaaa tcagcttctg tgtcagggat gctgtgtggt gtccatctga   3480

accccctgca tacgcgtagc taatgtgatc tccccacttt cacataagat ggtggccctg   3540

ccttcaggga atgtgggagc caggtgggag ccttcccgga tatttaagct agaagattct   3600

acagggagat tctccttgga tcaatatatg tctctcagtc aaagatgtaa aagcactttt   3660

gccttaaaaa gaatgttctg tttctaaata gagtcaacgt tgtcctcctc attggaattc   3720

actatgagtc agaatcatta gactgacttt tttttttcca tagtaatagt attttgcaga   3780

gtctcacaga gctgcagatc ttttgttcat cttgcagagt taacaagtct gatcctgtta   3840

gtccagattt cttaaatttg gccaagttat aataggagca gtagcttgag acccgaagtc   3900

aggaaacttt gacaatggat tttttttttt aatccagaga cttgtactgg aatttgcctt   3960

accctgtcag ctcatggact taaggtttca tcccgcttta tgagtgcttc tgaatccaag   4020

tcattgttac ctgaatttgc aaattaagtt gtgatattcg tgactgttaa attcctgtaa   4080

ttagattaac ctctttgctt gcttgtttgt tttctctcct attttagctt aaagtatcag   4140

tggttgagaa gagcttttcg gacctgttac taccccaagc tgtgtaatat acttgtataa   4200

cagaaatacc ttctatacaa accttttttt ctacttttag atagaaatgt ctactttttc   4260

agcagttctg tgaattaaag agcagagtga ctgtgggtct ggaatggctg gtgtacttgg   4320

gaatgtacta tcaggatttt acagcaatgc tgggaaatga cagggaaaat gacaggaatg   4380

aatctcacca gattttttat gtactcagca gagccttgag ttacggtgtt tattttccaa   4440

tcaagtgaag atatctccta cttctcctac tggaacatct cagcttctgc agtgaagaaa   4500

aattcctgtg atagttcagt tctttagttt ttctatttga aaaaaaaaaa tcatttaaat   4560

gatcctttgt tcacggctct ccttaatgac tgagtgaaca gttcctatct gtatatttga   4620

ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt tttttatcat aattaaaagc   4680

aaaaccatct ggatcaccta acagtcagag gtcagtatct cagcgtgtga attatagagg   4740

aaatacagag agaacctctt ccacttttac ttttcgtcca aataaaatgc atggtgtacc   4800

agaagttgaa gatcgggttg aggattgggg ctagctcgat gacactaagg ccccaacatc   4860

gcgggacctg ctgtggcgcg gattcttagg aacgctgttc tagccggccc cctctccagg   4920

ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa ccctgaggtg ccagcgcggg   4980

gagtgaggag gggtcagggg gctaaggatg caacctctga cgttctgcgc cttcctagga   5040

gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc agctctacaa   5100

gaagctaggc tctgtgacgg catagttttc agtagcttta tcacaatatt cacaatggag   5160

aattatatga catggtagca gaaataggcc cttttatgtg ttgcttctat tttacctcaa   5220

attgtagata tagggtaatc aataaaatcc atccatgcct ttcacacact aagt         5274


<210>  4273
<211>  998
<212>  PRT
<213>  Homo sapiens

<400>  4273

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr 
        595                 600                 605


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe 
    610                 615                 620


Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys 
625                 630                 635                 640


Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly 
                645                 650                 655


Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro 
            660                 665                 670


Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val 
        675                 680                 685


Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro 
    690                 695                 700


Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu 
705                 710                 715                 720


Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys 
                725                 730                 735


Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys 
            740                 745                 750


Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp 
        755                 760                 765


Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser 
    770                 775                 780


Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys 
785                 790                 795                 800


Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys 
                805                 810                 815


Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro 
            820                 825                 830


Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln 
        835                 840                 845


Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys 
    850                 855                 860


Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe 
865                 870                 875                 880


Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys 
                885                 890                 895


Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly 
            900                 905                 910


Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg 
        915                 920                 925


Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe 
    930                 935                 940


Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu 
945                 950                 955                 960


Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro 
                965                 970                 975


Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln 
            980                 985                 990


Glu Pro Asp Pro Thr Trp 
        995


<210>  4274
<211>  4556
<212>  DNA
<213>  Homo sapiens

<400>  4274
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gtcaaagaag attggaatgt   1980

cagaattacc aagctacgga agcaagtgga agagattttt aatttgaaat ttgcttagat   2040

ttgttgacag cggtttcctg gagtgctgtc ttgagaacga ttctgaggag gctcagcaag   2100

aaagagtgtt tcagttgatt gggtgtgtct gtcatggaga aggaactcaa gctcttggac   2160

tcaccgaggc agtaaaagta ccatatcctg tgtttgaatc aaacccggag ttcttgtatg   2220

tggaaggctt gccagagggg attcccttcc gaagccctac ctggtttgga attccacgac   2280

ttgaaaggat cgtccgcggg agtaataaaa tcaagttcgt tgttaaaaaa cctgaactag   2340

ttatttccta cttgcctcct gggatggcta gtaaaataaa cactaaagct ttgcagtccc   2400

ccaaaagacc acgaagtcct gggagtaatt caaaggttcc tgaaattgag gtcaccgtgg   2460

aaggccctaa taacaacaat cctcaaacct cagctgttcg aaccccgacc cagactaacg   2520

gttctaacgt tcccttcaag ccacgaggga gagagttttc ctttgaggcc tggaatgcca   2580

aaatcacgga cctaaaacag aaagttgaaa atctcttcaa tgagaaatgt ggggaagctc   2640

ttggccttaa acaagctgtg aaggtgccgt tcgcgttatt tgagtctttc ccggaagact   2700

tttatgtgga aggcttacct gagggtgtgc cattccgaag accatcgact tttggcattc   2760

cgaggctgga gaagatactc agaaacaaag ccaaaattaa gttcatcatt aaaaagcccg   2820

aaatgtttga gacggcgatt aaggagagca cctcctctaa gagccctccc agaaaaataa   2880

attcatcacc caatgttaat actactgcat caggtgttga agaccttaac atcattcagg   2940

tgacaattcc agatgatgat aatgaaagac tctcgaaagt tgaaaaagct agacagctaa   3000

gagaacaagt gaatgacctc tttagtcgga aatttggtga agctattggt atgggttttc   3060

ctgtgaaagt tccctacagg aaaatcacaa ttaaccctgg ctgtgtggtg gttgatggca   3120

tgcccccggg ggtgtccttc aaagccccca gctacctgga aatcagctcc atgagaagga   3180

tcttagactc tgccgagttt atcaaattca cggtcattag accatttcca ggacttgtga   3240

ttaataacca gctggttgat cagagtgagt cagaaggccc cgtgatacaa gaatcagctg   3300

aaccaagcca gttggaagtt ccagccacag aagaaataaa agagactgat ggaagctctc   3360

agatcaagca agaaccagac cccacgtggt agacctcttc cctcctaggc ttaaagtatc   3420

agtggttgag aagagctttt cggacctgtt actaccccaa gctgtgtaat atacttgtat   3480

aacagaaata ccttctatac aaaccttttt ttctactttt agatagaaat gtctactttt   3540

tcagcagttc tgtgaattaa agagcagagt gactgtgggt ctggaatggc tggtgtactt   3600

gggaatgtac tatcaggatt ttacagcaat gctgggaaat gacagggaaa atgacaggaa   3660

tgaatctcac cagatttttt atgtactcag cagagccttg agttacggtg tttattttcc   3720

aatcaagtga agatatctcc tacttctcct actggaacat ctcagcttct gcagtgaaga   3780

aaaattcctg tgatagttca gttctttagt ttttctattt gaaaaaaaaa aatcatttaa   3840

atgatccttt gttcacggct ctccttaatg actgagtgaa cagttcctat ctgtatattt   3900

gactaaacct tttcctaagc tatctctcat ggttcctatg tttttttatc ataattaaaa   3960

gcaaaaccat ctggatcacc taacagtcag aggtcagtat ctcagcgtgt gaattataga   4020

ggaaatacag agagaacctc ttccactttt acttttcgtc caaataaaat gcatggtgta   4080

ccagaagttg aagatcgggt tgaggattgg ggctagctcg atgacactaa ggccccaaca   4140

tcgcgggacc tgctgtggcg cggattctta ggaacgctgt tctagccggc cccctctcca   4200

ggggtcgccg tggccggcat tatttcctag ttcttcttgt aaccctgagg tgccagcgcg   4260

gggagtgagg aggggtcagg gggctaagga tgcaacctct gacgttctgc gccttcctag   4320

gagagtctta catgtgttga gatttcacaa gcaatgcgag ttgtaaaata ccagctctac   4380

aagaagctag gctctgtgac ggcatagttt tcagtagctt tatcacaata ttcacaatgg   4440

agaattatat gacatggtag cagaaatagg cccttttatg tgttgcttct attttacctc   4500

aaattgtaga tatagggtaa tcaataaaat ccatccatgc ctttcacaca ctaagt       4556


<210>  4275
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  4275

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535


<210>  4276
<211>  4989
<212>  DNA
<213>  Homo sapiens

<400>  4276
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gtcaaagaag attggaatgt cagaattacc aagctacgga   1920

agcaagtgga agagattttt aatttgaaat ttgctcaagc tcttggactc accgaggcag   1980

taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgaaagga tcgtccgcgg   2040

gagtaataaa atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc   2100

tgggatggct agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc   2160

tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa   2220

tcctcaaacc tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa   2280

gccacgaggg agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca   2340

gaaagttgaa aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt   2400

gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc   2460

tgagggtgtg ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact   2520

cagaaacaaa gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat   2580

taaggagagc acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa   2640

tactactgca tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga   2700

taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct   2760

ctttagtcgg aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag   2820

gaaaatcaca attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt   2880

caaagccccc agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt   2940

tatcaaattc acggtcatta gaccatttcc aggacttgtg attaataacc agctggttga   3000

tcagagtgag tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt   3060

tccagccaca gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga   3120

ccccacgtgg tagacctctt ccctcctagg gtaaatcagc ttctgtgtca gggatgctgt   3180

gtggtgtcca tctgaacccc ctgcatacgc gtagctaatg tgatctcccc actttcacat   3240

aagatggtgg ccctgccttc agggaatgtg ggagccaggt gggagccttc ccggatattt   3300

aagctagaag attctacagg gagattctcc ttggatcaat atatgtctct cagtcaaaga   3360

tgtaaaagca cttttgcctt aaaaagaatg ttctgtttct aaatagagtc aacgttgtcc   3420

tcctcattgg aattcactat gagtcagaat cattagactg actttttttt ttccatagta   3480

atagtatttt gcagagtctc acagagctgc agatcttttg ttcatcttgc agagttaaca   3540

agtctgatcc tgttagtcca gatttcttaa atttggccaa gttataatag gagcagtagc   3600

ttgagacccg aagtcaggaa actttgacaa tggatttttt tttttaatcc agagacttgt   3660

actggaattt gccttaccct gtcagctcat ggacttaagg tttcatcccg ctttatgagt   3720

gcttctgaat ccaagtcatt gttacctgaa tttgcaaatt aagttgtgat attcgtgact   3780

gttaaattcc tgtaattaga ttaacctctt tgcttgcttg tttgttttct ctcctatttt   3840

agcttaaagt atcagtggtt gagaagagct tttcggacct gttactaccc caagctgtgt   3900

aatatacttg tataacagaa ataccttcta tacaaacctt tttttctact tttagataga   3960

aatgtctact ttttcagcag ttctgtgaat taaagagcag agtgactgtg ggtctggaat   4020

ggctggtgta cttgggaatg tactatcagg attttacagc aatgctggga aatgacaggg   4080

aaaatgacag gaatgaatct caccagattt tttatgtact cagcagagcc ttgagttacg   4140

gtgtttattt tccaatcaag tgaagatatc tcctacttct cctactggaa catctcagct   4200

tctgcagtga agaaaaattc ctgtgatagt tcagttcttt agtttttcta tttgaaaaaa   4260

aaaaatcatt taaatgatcc tttgttcacg gctctcctta atgactgagt gaacagttcc   4320

tatctgtata tttgactaaa ccttttccta agctatctct catggttcct atgttttttt   4380

atcataatta aaagcaaaac catctggatc acctaacagt cagaggtcag tatctcagcg   4440

tgtgaattat agaggaaata cagagagaac ctcttccact tttacttttc gtccaaataa   4500

aatgcatggt gtaccagaag ttgaagatcg ggttgaggat tggggctagc tcgatgacac   4560

taaggcccca acatcgcggg acctgctgtg gcgcggattc ttaggaacgc tgttctagcc   4620

ggccccctct ccaggggtcg ccgtggccgg cattatttcc tagttcttct tgtaaccctg   4680

aggtgccagc gcggggagtg aggaggggtc agggggctaa ggatgcaacc tctgacgttc   4740

tgcgccttcc taggagagtc ttacatgtgt tgagatttca caagcaatgc gagttgtaaa   4800

ataccagctc tacaagaagc taggctctgt gacggcatag ttttcagtag ctttatcaca   4860

atattcacaa tggagaatta tatgacatgg tagcagaaat aggccctttt atgtgttgct   4920

tctattttac ctcaaattgt agatataggg taatcaataa aatccatcca tgcctttcac   4980

acactaagt                                                           4989


<210>  4277
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  4277

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
                485                 490                 495


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
            500                 505                 510


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
        515                 520                 525


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser 
    530                 535                 540


Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
545                 550                 555


<210>  4278
<211>  4219
<212>  DNA
<213>  Homo sapiens

<400>  4278
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagctca   2040

agctcttgga ctcaccgagg cagtaaaagt accatatcct gtgtttgaat caaacccgga   2100

gttcttgtat gtggaaggct tgccagaggg gattcccttc cgaagcccta cctggtttgg   2160

aattccacga cttgaaagga tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa   2220

acctgaacta gttatttcct acttgcctcc tgggatggct agtaaaataa acactaaagc   2280

tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga   2340

ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc tcagctgttc gaaccccgac   2400

ccagactaac ggttctaacg ttcccttcaa gccacgaggg agagagtttt cctttgaggc   2460

ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa aatctcttca atgagaaatg   2520

tggggaagct cttggcctta aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt   2580

cccggaagac ttttatgtgg aaggcttacc tgagggtgtg ccattccgaa gaccatcgac   2640

ttttggcatt ccgaggctgg agaagatact cagaaacaaa gccaaaatta agttcatcat   2700

taaaaagccc gaaatgtttg agacggcgat taaggagagc acctcctcta agagccctcc   2760

cagaaaaata aattcatcac ccaatgttaa tactactgca tcaggtgttg aagaccttaa   2820

catcattcag gtgacaattc cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc   2880

tagacagcta agagaacaag tgaatgacct ctttagtcgg aaatttggtg aagctattgg   2940

tatgggtttt cctgtgaaag ttccctacag gaaaatcaca attaaccctg gctgtgtggt   3000

ggttgatggc atgcccccgg gggtgtcctt caaagccccc agctacctgg aaatcagctc   3060

catgagaagg atcttagact ctgccgagtt tatcaaattc acggtcatta gaccatttcc   3120

aggacttgtg attaataacc agctggttga tcagagtgag tcagaaggcc ccgtgataca   3180

agaatcagct gaaccaagcc agttggaagt tccagccaca gaagaaataa aagagactga   3240

tggaagctct cagatcaagc aagaaccaga ccccacgtgg tagacctctt ccctcctagg   3300

cttaaagtat cagtggttga gaagagcttt tcggacctgt tactacccca agctgtagcc   3360

ttgagttacg gtgtttattt tccaatcaag tgaagatatc tcctacttct cctactggaa   3420

catctcagct tctgcagtga agaaaaattc ctgtgatagt tcagttcttt agtttttcta   3480

tttgaaaaaa aaaaatcatt taaatgatcc tttgttcacg gctctcctta atgactgagt   3540

gaacagttcc tatctgtata tttgactaaa ccttttccta agctatctct catggttcct   3600

atgttttttt atcataatta aaagcaaaac catctggatc acctaacagt cagaggtcag   3660

tatctcagcg tgtgaattat agaggaaata cagagagaac ctcttccact tttacttttc   3720

gtccaaataa aatgcatggt gtaccagaag ttgaagatcg ggttgaggat tggggctagc   3780

tcgatgacac taaggcccca acatcgcggg acctgctgtg gcgcggattc ttaggaacgc   3840

tgttctagcc ggccccctct ccaggggtcg ccgtggccgg cattatttcc tagttcttct   3900

tgtaaccctg aggtgccagc gcggggagtg aggaggggtc agggggctaa ggatgcaacc   3960

tctgacgttc tgcgccttcc taggagagtc ttacatgtgt tgagatttca caagcaatgc   4020

gagttgtaaa ataccagctc tacaagaagc taggctctgt gacggcatag ttttcagtag   4080

ctttatcaca atattcacaa tggagaatta tatgacatgg tagcagaaat aggccctttt   4140

atgtgttgct tctattttac ctcaaattgt agatataggg taatcaataa aatccatcca   4200

tgcctttcac acactaagt                                                4219


<210>  4279
<211>  953
<212>  PRT
<213>  Homo sapiens

<400>  4279

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu 
    530                 535                 540


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
545                 550                 555                 560


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
                565                 570                 575


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
            580                 585                 590


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
        595                 600                 605


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
    610                 615                 620


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
625                 630                 635                 640


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
                645                 650                 655


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
            660                 665                 670


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
        675                 680                 685


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
    690                 695                 700


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
705                 710                 715                 720


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
                725                 730                 735


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
            740                 745                 750


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
        755                 760                 765


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
    770                 775                 780


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
785                 790                 795                 800


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
                805                 810                 815


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
            820                 825                 830


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
        835                 840                 845


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
    850                 855                 860


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
865                 870                 875                 880


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
                885                 890                 895


Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser 
            900                 905                 910


Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu 
        915                 920                 925


Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln 
    930                 935                 940


Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  4280
<211>  4450
<212>  DNA
<213>  Homo sapiens

<400>  4280
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagc   2040

tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc   2100

ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc ctacctggtt   2160

tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa   2220

aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa taaacactaa   2280

agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg ttcctgaaat   2340

tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg ttcgaacccc   2400

gacccagact aacggttcta acgttccctt caagccacga gggagagagt tttcctttga   2460

ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct tcaatgagaa   2520

atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc   2580

tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc gaagaccatc   2640

gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa ttaagttcat   2700

cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct ctaagagccc   2760

tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg ttgaagacct   2820

taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga aagttgaaaa   2880

agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg gtgaagctat   2940

tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc ctggctgtgt   3000

ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc tggaaatcag   3060

ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca ttagaccatt   3120

tccaggactt gtgattaata accagctggt tgatcagagt gagtcagaag gccccgtgat   3180

acaagaatca gctgaaccaa gccagttgga agttccagcc acagaagaaa taaaagagac   3240

tgatggaagc tctcagatca agcaagaacc agaccccacg tggtagacct cttccctcct   3300

aggcttaaag tatcagtggt tgagaagagc ttttcggacc tgttactacc ccaagctgtg   3360

taatatactt gtataacaga aataccttct atacaaacct ttttttctac ttttagatag   3420

aaatgtctac tttttcagca gttctgtgaa ttaaagagca gagtgactgt gggtctggaa   3480

tggctggtgt acttgggaat gtactatcag gattttacag caatgctggg aaatgacagg   3540

gaaaatgaca ggaatgaatc tcaccagatt ttttatgtac tcagcagagc cttgagttac   3600

ggtgtttatt ttccaatcaa gtgaagatat ctcctacttc tcctactgga acatctcagc   3660

ttctgcagtg aagaaaaatt cctgtgatag ttcagttctt tagtttttct atttgaaaaa   3720

aaaaaatcat ttaaatgatc ctttgttcac ggctctcctt aatgactgag tgaacagttc   3780

ctatctgtat atttgactaa accttttcct aagctatctc tcatggttcc tatgtttttt   3840

tatcataatt aaaagcaaaa ccatctggat cacctaacag tcagaggtca gtatctcagc   3900

gtgtgaatta tagaggaaat acagagagaa cctcttccac ttttactttt cgtccaaata   3960

aaatgcatgg tgtaccagaa gttgaagatc gggttgagga ttggggctag ctcgatgaca   4020

ctaaggcccc aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg ctgttctagc   4080

cggccccctc tccaggggtc gccgtggccg gcattatttc ctagttcttc ttgtaaccct   4140

gaggtgccag cgcggggagt gaggaggggt cagggggcta aggatgcaac ctctgacgtt   4200

ctgcgccttc ctaggagagt cttacatgtg ttgagatttc acaagcaatg cgagttgtaa   4260

aataccagct ctacaagaag ctaggctctg tgacggcata gttttcagta gctttatcac   4320

aatattcaca atggagaatt atatgacatg gtagcagaaa taggcccttt tatgtgttgc   4380

ttctatttta cctcaaattg tagatatagg gtaatcaata aaatccatcc atgcctttca   4440

cacactaagt                                                          4450


<210>  4281
<211>  954
<212>  PRT
<213>  Homo sapiens

<400>  4281

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly 
    530                 535                 540


Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro 
545                 550                 555                 560


Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser 
                565                 570                 575


Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser 
            580                 585                 590


Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr 
        595                 600                 605


Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser 
    610                 615                 620


Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile 
625                 630                 635                 640


Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala 
                645                 650                 655


Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro 
            660                 665                 670


Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp 
        675                 680                 685


Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala 
    690                 695                 700


Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser 
705                 710                 715                 720


Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe 
                725                 730                 735


Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg 
            740                 745                 750


Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu 
        755                 760                 765


Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile 
    770                 775                 780


Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu 
785                 790                 795                 800


Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser 
                805                 810                 815


Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe 
            820                 825                 830


Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val 
        835                 840                 845


Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly 
    850                 855                 860


Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser 
865                 870                 875                 880


Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val 
                885                 890                 895


Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln 
            900                 905                 910


Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln 
        915                 920                 925


Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser 
    930                 935                 940


Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  4282
<211>  4326
<212>  DNA
<213>  Homo sapiens

<400>  4282
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   1980

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gcttagattt   2040

gttgacagcg gtttcctgga gtgctgtctt gagaacgatt ctgaggaggc tcagcaagaa   2100

agagtgtttc agttgattgg gtgtgtctgt catggagaag gaactcaagc tcttggactc   2160

accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgtatgtg   2220

gaaggcttgc cagaggggat tcccttccga agccctacct ggtttggaat tccacgactt   2280

gaaaggatcg tccgcgggag taataaaatc aagttcgttg ttaaaaaacc tgaactagtt   2340

atttcctact tgcctcctgg gatggctagt aaaataaaca ctaaagcttt gcagtccccc   2400

aaaagaccac gaagtcctgg gagtaattca aaggttcctg aaattgaggt caccgtggaa   2460

ggccctaata acaacaatcc tcaaacctca gctgttcgaa ccccgaccca gactaacggt   2520

tctaacgttc ccttcaagcc acgagggaga gagttttcct ttgaggcctg gaatgccaaa   2580

atcacggacc taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg ggaagctctt   2640

ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg agtctttccc ggaagacttt   2700

tatgtggaag gcttacctga gggtgtgcca ttccgaagac catcgacttt tggcattccg   2760

aggctggaga agatactcag aaacaaagcc aaaattaagt tcatcattaa aaagcccgaa   2820

atgtttgaga cggcgattaa ggagagcacc tcctctaaga gccctcccag aaaaataaat   2880

tcatcaccca atgttaatac tactgcatca ggtgttgaag accttaacat cattcaggtg   2940

acaattccag atgatgataa tgaaagactc tcgaaagttg aaaaagctag acagctaaga   3000

gaacaagtga atgacctctt tagtcggaaa tttggtgaag ctattggtat gggttttcct   3060

gtgaaagttc cctacaggaa aatcacaatt aaccctggct gtgtggtggt tgatggcatg   3120

cccccggggg tgtccttcaa agcccccagc tacctggaaa tcagctccat gagaaggatc   3180

ttagactctg ccgagtttat caaattcacg gtcattagac catttccagg acttgtgatt   3240

aataaccagc tggttgatca gagtgagtca gaaggccccg tgatacaaga atcagctgaa   3300

ccaagccagt tggaagttcc agccacagaa gaaataaaag agactgatgg aagctctcag   3360

atcaagcaag aaccagaccc cacgtggtag acctcttccc tcctaggctt aaagtatcag   3420

tggttgagaa gagcttttcg gacctgttac taccccaagc tgtagccttg agttacggtg   3480

tttattttcc aatcaagtga agatatctcc tacttctcct actggaacat ctcagcttct   3540

gcagtgaaga aaaattcctg tgatagttca gttctttagt ttttctattt gaaaaaaaaa   3600

aatcatttaa atgatccttt gttcacggct ctccttaatg actgagtgaa cagttcctat   3660

ctgtatattt gactaaacct tttcctaagc tatctctcat ggttcctatg tttttttatc   3720

ataattaaaa gcaaaaccat ctggatcacc taacagtcag aggtcagtat ctcagcgtgt   3780

gaattataga ggaaatacag agagaacctc ttccactttt acttttcgtc caaataaaat   3840

gcatggtgta ccagaagttg aagatcgggt tgaggattgg ggctagctcg atgacactaa   3900

ggccccaaca tcgcgggacc tgctgtggcg cggattctta ggaacgctgt tctagccggc   3960

cccctctcca ggggtcgccg tggccggcat tatttcctag ttcttcttgt aaccctgagg   4020

tgccagcgcg gggagtgagg aggggtcagg gggctaagga tgcaacctct gacgttctgc   4080

gccttcctag gagagtctta catgtgttga gatttcacaa gcaatgcgag ttgtaaaata   4140

ccagctctac aagaagctag gctctgtgac ggcatagttt tcagtagctt tatcacaata   4200

ttcacaatgg agaattatat gacatggtag cagaaatagg cccttttatg tgttgcttct   4260

attttacctc aaattgtaga tatagggtaa tcaataaaat ccatccatgc ctttcacaca   4320

ctaagt                                                              4326


<210>  4283
<211>  544
<212>  PRT
<213>  Homo sapiens

<400>  4283

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile 
        515                 520                 525


Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  4284
<211>  7745
<212>  DNA
<213>  Homo sapiens

<400>  4284
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gctcaagctc ttggactcac cgaggcagta aaagtaccat   1920

atcctgtgtt tgaatcaaac ccggagttct tgtatgtgga aggcttgcca gaggggattc   1980

ccttccgaag ccctacctgg tttggaattc cacgacttga aaggatcgtc cgcgggagta   2040

ataaaatcaa gttcgttgtt aaaaaacctg aactagttat ttcctacttg cctcctggga   2100

tggctagtaa aataaacact aaagctttgc agtcccccaa aagaccacga agtcctggga   2160

gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg ccctaataac aacaatcctc   2220

aaacctcagc tgttcgaacc ccgacccaga ctaacggttc taacgttccc ttcaagccac   2280

gagggagaga gttttccttt gaggcctgga atgccaaaat cacggaccta aaacagaaag   2340

ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg   2400

tgccgttcgc gttatttgag tctttcccgg aagactttta tgtggaaggc ttacctgagg   2460

gtgtgccatt ccgaagacca tcgacttttg gcattccgag gctggagaag atactcagaa   2520

acaaagccaa aattaagttc atcattaaaa agcccgaaat gtttgagacg gcgattaagg   2580

agagcacctc ctctaagagc cctcccagaa aaataaattc atcacccaat gttaatacta   2640

ctgcatcagg tgttgaagac cttaacatca ttcaggtgac aattccagat gatgataatg   2700

aaagactctc gaaagttgaa aaagctagac agctaagaga acaagtgaat gacctcttta   2760

gtcggaaatt tggtgaagct attggtatgg gttttcctgt gaaagttccc tacaggaaaa   2820

tcacaattaa ccctggctgt gtggtggttg atggcatgcc cccgggggtg tccttcaaag   2880

cccccagcta cctggaaatc agctccatga gaaggatctt agactctgcc gagtttatca   2940

aattcacggt cattaggtaa gtgagagttt cctgcttagt cacaggagcg aatctggagc   3000

tcatgaggct gactcttcta aaatgcagcc acaggtagtc atcgaatccg gcttcctatg   3060

ctgtgcaatc aacaaatcaa aataacttgt gtcatcatta gaatgtcaga tgtgcttcta   3120

cgaactaagc tgactctttt aattctttgg caaagggttg gcaaactagg actgtttgcc   3180

aaattcaggc tgcctcctat ttttagagtc ttcctgaaac acagctacac ccgtattatc   3240

catggctgct ttcctgtcac agtgagtaag tagctgggac tgagaaggca tggcctccaa   3300

agtctaaaat atttactctc tagcactttg tagaaaaacc ttagctaggc acagtggcta   3360

acgcctgtaa tcccagcatt ttgggaggcc aaggcaggca gatcacctga ggtcaggagt   3420

tccagaccag cctggccaac atggtgaaat cccatctcta caaaaataaa acagttagct   3480

gggcatgatg gcgggtgcct gtaatcccag ctactcggga ggctgaggca ggatagtcgc   3540

ttgaacccag gaggtggagg ttgcaatgag ccaagatcat gccactgcac tccagcctgg   3600

acgacagagt gagactccat cacaagaaaa aaagaacttt gtcaacctct gtcttagggc   3660

gccttgtcac aggcttcggg tcagacggat tcaaccttgc atcagccatt tgttagccag   3720

gtcactctgt tctttgtctg taaatgagat tgatcgttgt tcccactgag agtgtcagct   3780

ccttcccgta gagcaggcat gatgattgta ctcacctctg acaccattgt gagtgccaca   3840

ttccttccca cgtccttgtc actgtaagag atgcccacct gagcaccaac cccaggttat   3900

cttccccttt gtcttccagc cccccagaaa cagctacgac tcaacctacc caatcatttc   3960

atcatcagat tgccactgtc tctagttcag gtctcttggg actggcactc agaaatctca   4020

taataaatcc tcttgaggct tctcatacac tcgtcttctt ccaatcttct ttccctcaaa   4080

atctcatatt ttggttccac ttcacccacc gtcattctcc atatcactcc caggagttag   4140

gcaaaaagcc ccttccgttc ttccgtatgt taaacttaga atcactctgt tccctgctct   4200

gcgtttctat tttttgtttt tcctccattt actagtagct taacactttc taacagtgtt   4260

cttattattg atacgtatct atctcttcca taagcttata aggtcacgga taatacttct   4320

cattgtagta cgtaaatgac gtgggctaga tatgagttga ataaacagtt atacctgtaa   4380

attcttacag agtgaaaata aattgttata ctttacaatt tgtttctctc tttagaccat   4440

ttccaggact tgtgattaat aaccgtgagt attttgtgaa gtgttttgtt tttgtttttt   4500

cctggggtct gacgtgtgtg cgtgtgagtg tgtatacatg cttaacgtat atcacgttac   4560

ttcacctatg tcagtaacca ggccaaatac ttgttttagc cctcagtaaa aacaccaggc   4620

acttcctagt tgtaaaatta ttcaagcttc ttaacttcct atcctcgatg cacttaatca   4680

taaaatggta ataatagcac cgattttggg ggagtcgttc cagtagatgg aaagcatctg   4740

gaacaggtgt cagcaagctc ctgccgacgt gtatgcataa agttttattg aaaccaccat   4800

cgtgtccatt tgtttatggc agaactgaga gatggcagca gcaagtgtgt gcctgcaaaa   4860

cctaaaatat ttactaattg gctctgcaag aaaagagttt gcatccccct aacctagaac   4920

agtgtctagc ctctagtatg tgtttagcct acagtatgtg ctcagcgaat acaatctata   4980

tttattactg cttttatgac tgttataatt actgtgcttg gatttcgtta caaagtaagt   5040

cacaatgtgc ctgcttctgt tagtatttca gcacagtgcc tggcacacat ggggctctca   5100

aatattgctg agcgagtgaa caaatgtcct ttcaattcct taacgttgat gtcattttca   5160

atagtatttt gagccaaact taattttgcg agtgtgtttt gttttcttaa ctttattatt   5220

aaaaatgtat aaaagtgagg ccaggcgtgg tggctcacgc ctgtaatccc agcagtttgg   5280

gaggctgagg caggcggatc agttgaggtt gggagttgga gaccagcccg tccaacatgg   5340

tgaaagcctg tctctactaa aaatacaaaa atcagctggg tgtggtggcg cgtgcctgta   5400

atcccagcta ctcaggaggc tgaggcagga gagttgcttg aatcctagag gtggaggttg   5460

cagtgagctg agatcgtgcc attgcactcc agcctgggca acaagagcaa aactctgtcc   5520

caataaataa ataaataaaa tgttctcttt tgttcctgtt cttgtgcggt agtgtggtat   5580

agagttttat ggtaattact gtgaattagt gattctgagg gacatatcag aactctgagg   5640

tttgtttcct tctcatcttg agggaaacag caaatgtatg ttaaaatgct tttccaaggg   5700

aacaacacat ccttacatta tttaaaccaa tctgcttcat tttcagagct ggttgatcag   5760

agtgagtcag aaggccccgt gatacaagaa tcagctgaac caagccagtt ggaagttcca   5820

gccacagaag aaataaaaga gactgatgga agctctcaga tcaagcaaga accagacccc   5880

acgtggtaga cctcttccct cctagggtaa atcagcttct gtgtcaggga tgctgtgtgg   5940

tgtccatctg aaccccctgc atacgcgtag ctaatgtgat ctccccactt tcacataaga   6000

tggtggccct gccttcaggg aatgtgggag ccaggtggga gccttcccgg atatttaagc   6060

tagaagattc tacagggaga ttctccttgg atcaatatat gtctctcagt caaagatgta   6120

aaagcacttt tgccttaaaa agaatgttct gtttctaaat agagtcaacg ttgtcctcct   6180

cattggaatt cactatgagt cagaatcatt agactgactt ttttttttcc atagtaatag   6240

tattttgcag agtctcacag agctgcagat cttttgttca tcttgcagag ttaacaagtc   6300

tgatcctgtt agtccagatt tcttaaattt ggccaagtta taataggagc agtagcttga   6360

gacccgaagt caggaaactt tgacaatgga tttttttttt taatccagag acttgtactg   6420

gaatttgcct taccctgtca gctcatggac ttaaggtttc atcccgcttt atgagtgctt   6480

ctgaatccaa gtcattgtta cctgaatttg caaattaagt tgtgatattc gtgactgtta   6540

aattcctgta attagattaa cctctttgct tgcttgtttg ttttctctcc tattttagct   6600

taaagtatca gtggttgaga agagcttttc ggacctgtta ctaccccaag ctgtgtaata   6660

tacttgtata acagaaatac cttctataca aacctttttt tctactttta gatagaaatg   6720

tctacttttt cagcagttct gtgaattaaa gagcagagtg actgtgggtc tggaatggct   6780

ggtgtacttg ggaatgtact atcaggattt tacagcaatg ctgggaaatg acagggaaaa   6840

tgacaggaat gaatctcacc agatttttta tgtactcagc agagccttga gttacggtgt   6900

ttattttcca atcaagtgaa gatatctcct acttctccta ctggaacatc tcagcttctg   6960

cagtgaagaa aaattcctgt gatagttcag ttctttagtt tttctatttg aaaaaaaaaa   7020

atcatttaaa tgatcctttg ttcacggctc tccttaatga ctgagtgaac agttcctatc   7080

tgtatatttg actaaacctt ttcctaagct atctctcatg gttcctatgt ttttttatca   7140

taattaaaag caaaaccatc tggatcacct aacagtcaga ggtcagtatc tcagcgtgtg   7200

aattatagag gaaatacaga gagaacctct tccactttta cttttcgtcc aaataaaatg   7260

catggtgtac cagaagttga agatcgggtt gaggattggg gctagctcga tgacactaag   7320

gccccaacat cgcgggacct gctgtggcgc ggattcttag gaacgctgtt ctagccggcc   7380

ccctctccag gggtcgccgt ggccggcatt atttcctagt tcttcttgta accctgaggt   7440

gccagcgcgg ggagtgagga ggggtcaggg ggctaaggat gcaacctctg acgttctgcg   7500

ccttcctagg agagtcttac atgtgttgag atttcacaag caatgcgagt tgtaaaatac   7560

cagctctaca agaagctagg ctctgtgacg gcatagtttt cagtagcttt atcacaatat   7620

tcacaatgga gaattatatg acatggtagc agaaataggc ccttttatgt gttgcttcta   7680

ttttacctca aattgtagat atagggtaat caataaaatc catccatgcc tttcacacac   7740

taagt                                                               7745


<210>  4285
<211>  852
<212>  PRT
<213>  Homo sapiens

<400>  4285

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala 
                485                 490                 495


Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser 
            500                 505                 510


Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        515                 520                 525


Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg 
    530                 535                 540


Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile 
545                 550                 555                 560


Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu 
                565                 570                 575


Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro 
            580                 585                 590


Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr 
        595                 600                 605


Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe 
    610                 615                 620


Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile 
625                 630                 635                 640


Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly 
                645                 650                 655


Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe 
            660                 665                 670


Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val 
        675                 680                 685


Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile 
    690                 695                 700


Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met 
705                 710                 715                 720


Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg 
                725                 730                 735


Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu 
            740                 745                 750


Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg 
        755                 760                 765


Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp 
    770                 775                 780


Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val 
785                 790                 795                 800


Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val 
                805                 810                 815


Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu 
            820                 825                 830


Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe 
        835                 840                 845


Thr Val Ile Arg 
    850


<210>  4286
<211>  4268
<212>  DNA
<213>  Homo sapiens

<400>  4286
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagctc   1860

aagctcttgg actcaccgag gcagtaaaag taccatatcc tgtgtttgaa tcaaacccgg   1920

agttcttgta tgtggaaggc ttgccagagg ggattccctt ccgaagccct acctggtttg   1980

gaattccacg acttgaaagg atcgtccgcg ggagtaataa aatcaagttc gttgttaaaa   2040

aacctgaact agttatttcc tacttgcctc ctgggatggc tagtaaaata aacactaaag   2100

ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa ttcaaaggtt cctgaaattg   2160

aggtcaccgt ggaaggccct aataacaaca atcctcaaac ctcagctgtt cgaaccccga   2220

cccagactaa cggttctaac gttcccttca agccacgagg gagagagttt tcctttgagg   2280

cctggaatgc caaaatcacg gacctaaaac agaaagttga aaatctcttc aatgagaaat   2340

gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc gttcgcgtta tttgagtctt   2400

tcccggaaga cttttatgtg gaaggcttac ctgagggtgt gccattccga agaccatcga   2460

cttttggcat tccgaggctg gagaagatac tcagaaacaa agccaaaatt aagttcatca   2520

ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag cacctcctct aagagccctc   2580

ccagaaaaat aaattcatca cccaatgtta atactactgc atcaggtgtt gaagacctta   2640

acatcattca ggtgacaatt ccagatgatg ataatgaaag actctcgaaa gttgaaaaag   2700

ctagacagct aagagaacaa gtgaatgacc tctttagtcg gaaatttggt gaagctattg   2760

gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac aattaaccct ggctgtgtgg   2820

tggttgatgg catgcccccg ggggtgtcct tcaaagcccc cagctacctg gaaatcagct   2880

ccatgagaag gatcttagac tctgccgagt ttatcaaatt cacggtcatt agaccatttc   2940

caggacttgt gattaataac cagctggttg atcagagtga gtcagaaggc cccgtgatac   3000

aagaatcagc tgaaccaagc cagttggaag ttccagccac agaagaaata aaagagactg   3060

atggaagctc tcagatcaag caagaaccag accccacgtg gtagacctct tccctcctag   3120

gcttaaagta tcagtggttg agaagagctt ttcggacctg ttactacccc aagctgtgta   3180

atatacttgt ataacagaaa taccttctat acaaaccttt ttttctactt ttagatagaa   3240

atgtctactt tttcagcagt tctgtgaatt aaagagcaga gtgactgtgg gtctggaatg   3300

gctggtgtac ttgggaatgt actatcagga ttttacagca atgctgggaa atgacaggga   3360

aaatgacagg aatgaatctc accagatttt ttatgtactc agcagagcct tgagttacgg   3420

tgtttatttt ccaatcaagt gaagatatct cctacttctc ctactggaac atctcagctt   3480

ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa   3540

aaaatcattt aaatgatcct ttgttcacgg ctctccttaa tgactgagtg aacagttcct   3600

atctgtatat ttgactaaac cttttcctaa gctatctctc atggttccta tgttttttta   3660

tcataattaa aagcaaaacc atctggatca cctaacagtc agaggtcagt atctcagcgt   3720

gtgaattata gaggaaatac agagagaacc tcttccactt ttacttttcg tccaaataaa   3780

atgcatggtg taccagaagt tgaagatcgg gttgaggatt ggggctagct cgatgacact   3840

aaggccccaa catcgcggga cctgctgtgg cgcggattct taggaacgct gttctagccg   3900

gccccctctc caggggtcgc cgtggccggc attatttcct agttcttctt gtaaccctga   3960

ggtgccagcg cggggagtga ggaggggtca gggggctaag gatgcaacct ctgacgttct   4020

gcgccttcct aggagagtct tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa   4080

taccagctct acaagaagct aggctctgtg acggcatagt tttcagtagc tttatcacaa   4140

tattcacaat ggagaattat atgacatggt agcagaaata ggccctttta tgtgttgctt   4200

ctattttacc tcaaattgta gatatagggt aatcaataaa atccatccat gcctttcaca   4260

cactaagt                                                            4268


<210>  4287
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  4287

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu 
            420                 425                 430


Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu 
        435                 440                 445


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp 
    450                 455                 460


Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile 
465                 470                 475                 480


Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro 
                485                 490                 495


Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg 
            500                 505                 510


Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr 
        515                 520                 525


Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr 
    530                 535                 540


Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg 
545                 550                 555                 560


Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln 
                565                 570                 575


Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu 
            580                 585                 590


Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu 
        595                 600                 605


Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro 
    610                 615                 620


Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala 
625                 630                 635                 640


Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile 
                645                 650                 655


Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser 
            660                 665                 670


Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile 
        675                 680                 685


Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu 
    690                 695                 700


Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys 
705                 710                 715                 720


Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg 
                725                 730                 735


Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro 
            740                 745                 750


Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg 
        755                 760                 765


Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro 
    770                 775                 780


Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser 
785                 790                 795                 800


Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val 
                805                 810                 815


Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys 
            820                 825                 830


Gln Glu Pro Asp Pro Thr Trp 
        835


<210>  4288
<211>  4079
<212>  DNA
<213>  Homo sapiens

<400>  4288
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagctca agctcttgga ctcaccgagg   1920

cagtaaaagt accatatcct gtgtttgaat caaacccgga gttcttgtat gtggaaggct   1980

tgccagaggg gattcccttc cgaagcccta cctggtttgg aattccacga cttgaaagga   2040

tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa acctgaacta gttatttcct   2100

acttgcctcc tgggatggct agtaaaataa acactaaagc tttgcagtcc cccaaaagac   2160

cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta   2220

ataacaacaa tcctcaaacc tcagctgttc gaaccccgac ccagactaac ggttctaacg   2280

ttcccttcaa gccacgaggg agagagtttt cctttgaggc ctggaatgcc aaaatcacgg   2340

acctaaaaca gaaagttgaa aatctcttca atgagaaatg tggggaagct cttggcctta   2400

aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg   2460

aaggcttacc tgagggtgtg ccattccgaa gaccatcgac ttttggcatt ccgaggctgg   2520

agaagatact cagaaacaaa gccaaaatta agttcatcat taaaaagccc gaaatgtttg   2580

agacggcgat taaggagagc acctcctcta agagccctcc cagaaaaata aattcatcac   2640

ccaatgttaa tactactgca tcaggtgttg aagaccttaa catcattcag gtgacaattc   2700

cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta agagaacaag   2760

tgaatgacct ctttagtcgg aaatttggtg aagctattgg tatgggtttt cctgtgaaag   2820

ttccctacag gaaaatcaca attaaccctg gctgtgtggt ggttgatggc atgcccccgg   2880

gggtgtcctt caaagccccc agctacctgg aaatcagctc catgagaagg atcttagact   2940

ctgccgagtt tatcaaattc acggtcatta gaccatttcc aggacttgtg attaataacc   3000

agctggttga tcagagtgag tcagaaggcc ccgtgataca agaatcagct gaaccaagcc   3060

agttggaagt tccagccaca gaagaaataa aagagactga tggaagctct cagatcaagc   3120

aagaaccaga ccccacgtgg tagacctctt ccctcctagg cttaaagtat cagtggttga   3180

gaagagcttt tcggacctgt tactacccca agctgtagcc ttgagttacg gtgtttattt   3240

tccaatcaag tgaagatatc tcctacttct cctactggaa catctcagct tctgcagtga   3300

agaaaaattc ctgtgatagt tcagttcttt agtttttcta tttgaaaaaa aaaaatcatt   3360

taaatgatcc tttgttcacg gctctcctta atgactgagt gaacagttcc tatctgtata   3420

tttgactaaa ccttttccta agctatctct catggttcct atgttttttt atcataatta   3480

aaagcaaaac catctggatc acctaacagt cagaggtcag tatctcagcg tgtgaattat   3540

agaggaaata cagagagaac ctcttccact tttacttttc gtccaaataa aatgcatggt   3600

gtaccagaag ttgaagatcg ggttgaggat tggggctagc tcgatgacac taaggcccca   3660

acatcgcggg acctgctgtg gcgcggattc ttaggaacgc tgttctagcc ggccccctct   3720

ccaggggtcg ccgtggccgg cattatttcc tagttcttct tgtaaccctg aggtgccagc   3780

gcggggagtg aggaggggtc agggggctaa ggatgcaacc tctgacgttc tgcgccttcc   3840

taggagagtc ttacatgtgt tgagatttca caagcaatgc gagttgtaaa ataccagctc   3900

tacaagaagc taggctctgt gacggcatag ttttcagtag ctttatcaca atattcacaa   3960

tggagaatta tatgacatgg tagcagaaat aggccctttt atgtgttgct tctattttac   4020

ctcaaattgt agatataggg taatcaataa aatccatcca tgcctttcac acactaagt    4079


<210>  4289
<211>  913
<212>  PRT
<213>  Homo sapiens

<400>  4289

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
            500                 505                 510


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
        515                 520                 525


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
    530                 535                 540


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
545                 550                 555                 560


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
                565                 570                 575


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
            580                 585                 590


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
        595                 600                 605


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
    610                 615                 620


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
625                 630                 635                 640


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
                645                 650                 655


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
            660                 665                 670


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
        675                 680                 685


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
    690                 695                 700


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
705                 710                 715                 720


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
                725                 730                 735


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
            740                 745                 750


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
        755                 760                 765


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
    770                 775                 780


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
785                 790                 795                 800


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
                805                 810                 815


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
            820                 825                 830


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
        835                 840                 845


Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile 
    850                 855                 860


Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln 
865                 870                 875                 880


Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile 
                885                 890                 895


Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr 
            900                 905                 910


Trp 



<210>  4290
<211>  4123
<212>  DNA
<213>  Homo sapiens

<400>  4290
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040

taccatatcc tgtgtttgaa tcaaacccgg agttcttgaa aggatcgtcc gcgggagtaa   2100

taaaatcaag ttcgttgtta aaaaacctga actagttatt tcctacttgc ctcctgggat   2160

ggctagtaaa ataaacacta aagctttgca gtcccccaaa agaccacgaa gtcctgggag   2220

taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc cctaataaca acaatcctca   2280

aacctcagct gttcgaaccc cgacccagac taacggttct aacgttccct tcaagccacg   2340

agggagagag ttttcctttg aggcctggaa tgccaaaatc acggacctaa aacagaaagt   2400

tgaaaatctc ttcaatgaga aatgtgggga agctcttggc cttaaacaag ctgtgaaggt   2460

gccgttcgcg ttatttgagt ctttcccgga agacttttat gtggaaggct tacctgaggg   2520

tgtgccattc cgaagaccat cgacttttgg cattccgagg ctggagaaga tactcagaaa   2580

caaagccaaa attaagttca tcattaaaaa gcccgaaatg tttgagacgg cgattaagga   2640

gagcacctcc tctaagagcc ctcccagaaa aataaattca tcacccaatg ttaatactac   2700

tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca attccagatg atgataatga   2760

aagactctcg aaagttgaaa aagctagaca gctaagagaa caagtgaatg acctctttag   2820

tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg aaagttccct acaggaaaat   2880

cacaattaac cctggctgtg tggtggttga tggcatgccc ccgggggtgt ccttcaaagc   2940

ccccagctac ctggaaatca gctccatgag aaggatctta gactctgccg agtttatcaa   3000

attcacggtc attagaccat ttccaggact tgtgattaat aaccagctgg ttgatcagag   3060

tgagtcagaa ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc   3120

cacagaagaa ataaaagaga ctgatggaag ctctcagatc aagcaagaac cagaccccac   3180

gtggtagacc tcttccctcc taggcttaaa gtatcagtgg ttgagaagag cttttcggac   3240

ctgttactac cccaagctgt agccttgagt tacggtgttt attttccaat caagtgaaga   3300

tatctcctac ttctcctact ggaacatctc agcttctgca gtgaagaaaa attcctgtga   3360

tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat catttaaatg atcctttgtt   3420

cacggctctc cttaatgact gagtgaacag ttcctatctg tatatttgac taaacctttt   3480

cctaagctat ctctcatggt tcctatgttt ttttatcata attaaaagca aaaccatctg   3540

gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa ttatagagga aatacagaga   3600

gaacctcttc cacttttact tttcgtccaa ataaaatgca tggtgtacca gaagttgaag   3660

atcgggttga ggattggggc tagctcgatg acactaaggc cccaacatcg cgggacctgc   3720

tgtggcgcgg attcttagga acgctgttct agccggcccc ctctccaggg gtcgccgtgg   3780

ccggcattat ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg   3840

ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc ttcctaggag agtcttacat   3900

gtgttgagat ttcacaagca atgcgagttg taaaatacca gctctacaag aagctaggct   3960

ctgtgacggc atagttttca gtagctttat cacaatattc acaatggaga attatatgac   4020

atggtagcag aaataggccc ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat   4080

agggtaatca ataaaatcca tccatgcctt tcacacacta agt                     4123


<210>  4291
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  4291

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
    450                 455                 460


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
465                 470                 475                 480


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
                485                 490                 495


Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu 
            500                 505                 510


Lys Asn Leu Asn 
        515


<210>  4292
<211>  5134
<212>  DNA
<213>  Homo sapiens

<400>  4292
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   1980

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2040

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2100

tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg tttggaattc   2160

cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg   2220

aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc   2280

agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca   2340

ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga   2400

ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga   2460

atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg   2520

aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg   2580

aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg   2640

gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa   2700

agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa   2760

aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca   2820

ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac   2880

agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg   2940

gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg   3000

atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga   3060

gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca tttccaggac   3120

ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat   3180

cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa   3240

gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc ctagggtaaa   3300

tcagcttctg tgtcagggat gctgtgtggt gtccatctga accccctgca tacgcgtagc   3360

taatgtgatc tccccacttt cacataagat ggtggccctg ccttcaggga atgtgggagc   3420

caggtgggag ccttcccgga tatttaagct agaagattct acagggagat tctccttgga   3480

tcaatatatg tctctcagtc aaagatgtaa aagcactttt gccttaaaaa gaatgttctg   3540

tttctaaata gagtcaacgt tgtcctcctc attggaattc actatgagtc agaatcatta   3600

gactgacttt tttttttcca tagtaatagt attttgcaga gtctcacaga gctgcagatc   3660

ttttgttcat cttgcagagt taacaagtct gatcctgtta gtccagattt cttaaatttg   3720

gccaagttat aataggagca gtagcttgag acccgaagtc aggaaacttt gacaatggat   3780

tttttttttt aatccagaga cttgtactgg aatttgcctt accctgtcag ctcatggact   3840

taaggtttca tcccgcttta tgagtgcttc tgaatccaag tcattgttac ctgaatttgc   3900

aaattaagtt gtgatattcg tgactgttaa attcctgtaa ttagattaac ctctttgctt   3960

gcttgtttgt tttctctcct attttagctt aaagtatcag tggttgagaa gagcttttcg   4020

gacctgttac taccccaagc tgtgtaatat acttgtataa cagaaatacc ttctatacaa   4080

accttttttt ctacttttag atagaaatgt ctactttttc agcagttctg tgaattaaag   4140

agcagagtga ctgtgggtct ggaatggctg gtgtacttgg gaatgtacta tcaggatttt   4200

acagcaatgc tgggaaatga cagggaaaat gacaggaatg aatctcacca gattttttat   4260

gtactcagca gagccttgag ttacggtgtt tattttccaa tcaagtgaag atatctccta   4320

cttctcctac tggaacatct cagcttctgc agtgaagaaa aattcctgtg atagttcagt   4380

tctttagttt ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt tcacggctct   4440

ccttaatgac tgagtgaaca gttcctatct gtatatttga ctaaaccttt tcctaagcta   4500

tctctcatgg ttcctatgtt tttttatcat aattaaaagc aaaaccatct ggatcaccta   4560

acagtcagag gtcagtatct cagcgtgtga attatagagg aaatacagag agaacctctt   4620

ccacttttac ttttcgtcca aataaaatgc atggtgtacc agaagttgaa gatcgggttg   4680

aggattgggg ctagctcgat gacactaagg ccccaacatc gcgggacctg ctgtggcgcg   4740

gattcttagg aacgctgttc tagccggccc cctctccagg ggtcgccgtg gccggcatta   4800

tttcctagtt cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg   4860

gctaaggatg caacctctga cgttctgcgc cttcctagga gagtcttaca tgtgttgaga   4920

tttcacaagc aatgcgagtt gtaaaatacc agctctacaa gaagctaggc tctgtgacgg   4980

catagttttc agtagcttta tcacaatatt cacaatggag aattatatga catggtagca   5040

gaaataggcc cttttatgtg ttgcttctat tttacctcaa attgtagata tagggtaatc   5100

aataaaatcc atccatgcct ttcacacact aagt                               5134


<210>  4293
<211>  958
<212>  PRT
<213>  Homo sapiens

<400>  4293

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile 
        515                 520                 525


Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
545                 550                 555                 560


Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile 
                565                 570                 575


Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile 
            580                 585                 590


Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu 
        595                 600                 605


Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys 
    610                 615                 620


Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys 
625                 630                 635                 640


Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro 
                645                 650                 655


Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val 
            660                 665                 670


Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala 
        675                 680                 685


Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys 
    690                 695                 700


Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala 
705                 710                 715                 720


Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu 
                725                 730                 735


Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu 
            740                 745                 750


Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro 
        755                 760                 765


Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro 
    770                 775                 780


Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly 
785                 790                 795                 800


Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn 
                805                 810                 815


Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val 
            820                 825                 830


Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe 
        835                 840                 845


Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val 
    850                 855                 860


Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr 
865                 870                 875                 880


Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile 
                885                 890                 895


Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln 
            900                 905                 910


Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala 
        915                 920                 925


Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr 
    930                 935                 940


Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950                 955


<210>  4294
<211>  4364
<212>  DNA
<213>  Homo sapiens

<400>  4294
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gtcaaagaag attggaatgt cagaattacc aagctacgga   1920

agcaagtgga agagattttt aatttgaaat ttgctcaagc tcttggactc accgaggcag   1980

taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgtatgtg gaaggcttgc   2040

cagaggggat tcccttccga agccctacct ggtttggaat tccacgactt gaaaggatcg   2100

tccgcgggag taataaaatc aagttcgttg ttaaaaaacc tgaactagtt atttcctact   2160

tgcctcctgg gatggctagt aaaataaaca ctaaagcttt gcagtccccc aaaagaccac   2220

gaagtcctgg gagtaattca aaggttcctg aaattgaggt caccgtggaa ggccctaata   2280

acaacaatcc tcaaacctca gctgttcgaa ccccgaccca gactaacggt tctaacgttc   2340

ccttcaagcc acgagggaga gagttttcct ttgaggcctg gaatgccaaa atcacggacc   2400

taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg ggaagctctt ggccttaaac   2460

aagctgtgaa ggtgccgttc gcgttatttg agtctttccc ggaagacttt tatgtggaag   2520

gcttacctga gggtgtgcca ttccgaagac catcgacttt tggcattccg aggctggaga   2580

agatactcag aaacaaagcc aaaattaagt tcatcattaa aaagcccgaa atgtttgaga   2640

cggcgattaa ggagagcacc tcctctaaga gccctcccag aaaaataaat tcatcaccca   2700

atgttaatac tactgcatca ggtgttgaag accttaacat cattcaggtg acaattccag   2760

atgatgataa tgaaagactc tcgaaagttg aaaaagctag acagctaaga gaacaagtga   2820

atgacctctt tagtcggaaa tttggtgaag ctattggtat gggttttcct gtgaaagttc   2880

cctacaggaa aatcacaatt aaccctggct gtgtggtggt tgatggcatg cccccggggg   2940

tgtccttcaa agcccccagc tacctggaaa tcagctccat gagaaggatc ttagactctg   3000

ccgagtttat caaattcacg gtcattagac catttccagg acttgtgatt aataaccagc   3060

tggttgatca gagtgagtca gaaggccccg tgatacaaga atcagctgaa ccaagccagt   3120

tggaagttcc agccacagaa gaaataaaag agactgatgg aagctctcag atcaagcaag   3180

aaccagaccc cacgtggtag acctcttccc tcctaggctt aaagtatcag tggttgagaa   3240

gagcttttcg gacctgttac taccccaagc tgtgtaatat acttgtataa cagaaatacc   3300

ttctatacaa accttttttt ctacttttag atagaaatgt ctactttttc agcagttctg   3360

tgaattaaag agcagagtga ctgtgggtct ggaatggctg gtgtacttgg gaatgtacta   3420

tcaggatttt acagcaatgc tgggaaatga cagggaaaat gacaggaatg aatctcacca   3480

gattttttat gtactcagca gagccttgag ttacggtgtt tattttccaa tcaagtgaag   3540

atatctccta cttctcctac tggaacatct cagcttctgc agtgaagaaa aattcctgtg   3600

atagttcagt tctttagttt ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt   3660

tcacggctct ccttaatgac tgagtgaaca gttcctatct gtatatttga ctaaaccttt   3720

tcctaagcta tctctcatgg ttcctatgtt tttttatcat aattaaaagc aaaaccatct   3780

ggatcaccta acagtcagag gtcagtatct cagcgtgtga attatagagg aaatacagag   3840

agaacctctt ccacttttac ttttcgtcca aataaaatgc atggtgtacc agaagttgaa   3900

gatcgggttg aggattgggg ctagctcgat gacactaagg ccccaacatc gcgggacctg   3960

ctgtggcgcg gattcttagg aacgctgttc tagccggccc cctctccagg ggtcgccgtg   4020

gccggcatta tttcctagtt cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag   4080

gggtcagggg gctaaggatg caacctctga cgttctgcgc cttcctagga gagtcttaca   4140

tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc agctctacaa gaagctaggc   4200

tctgtgacgg catagttttc agtagcttta tcacaatatt cacaatggag aattatatga   4260

catggtagca gaaataggcc cttttatgtg ttgcttctat tttacctcaa attgtagata   4320

tagggtaatc aataaaatcc atccatgcct ttcacacact aagt                    4364


<210>  4295
<211>  932
<212>  PRT
<213>  Homo sapiens

<400>  4295

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
                485                 490                 495


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
            500                 505                 510


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
        515                 520                 525


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu 
    530                 535                 540


Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile 
545                 550                 555                 560


Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val 
                565                 570                 575


Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala 
            580                 585                 590


Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser 
        595                 600                 605


Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly 
    610                 615                 620


Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln 
625                 630                 635                 640


Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser 
                645                 650                 655


Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu 
            660                 665                 670


Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala 
        675                 680                 685


Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr 
    690                 695                 700


Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe 
705                 710                 715                 720


Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys 
                725                 730                 735


Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser 
            740                 745                 750


Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val 
        755                 760                 765


Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr 
    770                 775                 780


Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg 
785                 790                 795                 800


Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu 
                805                 810                 815


Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr 
            820                 825                 830


Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser 
        835                 840                 845


Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu 
    850                 855                 860


Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly 
865                 870                 875                 880


Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro 
                885                 890                 895


Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr 
            900                 905                 910


Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro 
        915                 920                 925


Asp Pro Thr Trp 
    930


<210>  4296
<211>  4218
<212>  DNA
<213>  Homo sapiens

<400>  4296
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   2040

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2100

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2160

tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg tttggaattc   2220

cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg   2280

aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc   2340

agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca   2400

ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga   2460

ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga   2520

atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg   2580

aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg   2640

aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg   2700

gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa   2760

agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa   2820

aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca   2880

ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac   2940

agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg   3000

gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg   3060

atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga   3120

gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca tttccaggac   3180

ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat   3240

cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa   3300

gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc ctaggagcct   3360

tgagttacgg tgtttatttt ccaatcaagt gaagatatct cctacttctc ctactggaac   3420

atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta gtttttctat   3480

ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg ctctccttaa tgactgagtg   3540

aacagttcct atctgtatat ttgactaaac cttttcctaa gctatctctc atggttccta   3600

tgttttttta tcataattaa aagcaaaacc atctggatca cctaacagtc agaggtcagt   3660

atctcagcgt gtgaattata gaggaaatac agagagaacc tcttccactt ttacttttcg   3720

tccaaataaa atgcatggtg taccagaagt tgaagatcgg gttgaggatt ggggctagct   3780

cgatgacact aaggccccaa catcgcggga cctgctgtgg cgcggattct taggaacgct   3840

gttctagccg gccccctctc caggggtcgc cgtggccggc attatttcct agttcttctt   3900

gtaaccctga ggtgccagcg cggggagtga ggaggggtca gggggctaag gatgcaacct   3960

ctgacgttct gcgccttcct aggagagtct tacatgtgtt gagatttcac aagcaatgcg   4020

agttgtaaaa taccagctct acaagaagct aggctctgtg acggcatagt tttcagtagc   4080

tttatcacaa tattcacaat ggagaattat atgacatggt agcagaaata ggccctttta   4140

tgtgttgctt ctattttacc tcaaattgta gatatagggt aatcaataaa atccatccat   4200

gcctttcaca cactaagt                                                 4218


<210>  4297
<211>  978
<212>  PRT
<213>  Homo sapiens

<400>  4297

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu 
            580                 585                 590


Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg 
        595                 600                 605


Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys 
    610                 615                 620


Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys 
625                 630                 635                 640


Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly 
                645                 650                 655


Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn 
            660                 665                 670


Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn 
        675                 680                 685


Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu 
    690                 695                 700


Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu 
705                 710                 715                 720


Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys 
                725                 730                 735


Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu 
            740                 745                 750


Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile 
        755                 760                 765


Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile 
    770                 775                 780


Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser 
785                 790                 795                 800


Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr 
                805                 810                 815


Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro 
            820                 825                 830


Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu 
        835                 840                 845


Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile 
    850                 855                 860


Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn 
865                 870                 875                 880


Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys 
                885                 890                 895


Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser 
            900                 905                 910


Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val 
        915                 920                 925


Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile 
    930                 935                 940


Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu 
945                 950                 955                 960


Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro 
                965                 970                 975


Thr Trp 



<210>  4298
<211>  4273
<212>  DNA
<213>  Homo sapiens

<400>  4298
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1860

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1920

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1980

aatcaaaccc ggagttcttg aaaggatcgt ccgcgggagt aataaaatca agttcgttgt   2040

taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta aaataaacac   2100

taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa aggttcctga   2160

aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag ctgttcgaac   2220

cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag agttttcctt   2280

tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc tcttcaatga   2340

gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg cgttatttga   2400

gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat tccgaagacc   2460

atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca aaattaagtt   2520

catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct cctctaagag   2580

ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag gtgttgaaga   2640

ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct cgaaagttga   2700

aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat ttggtgaagc   2760

tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta accctggctg   2820

tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct acctggaaat   2880

cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg tcattagacc   2940

atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag aaggccccgt   3000

gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag aaataaaaga   3060

gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga cctcttccct   3120

cctaggctta aagtatcagt ggttgagaag agcttttcgg acctgttact accccaagct   3180

gtgtaatata cttgtataac agaaatacct tctatacaaa cctttttttc tacttttaga   3240

tagaaatgtc tactttttca gcagttctgt gaattaaaga gcagagtgac tgtgggtctg   3300

gaatggctgg tgtacttggg aatgtactat caggatttta cagcaatgct gggaaatgac   3360

agggaaaatg acaggaatga atctcaccag attttttatg tactcagcag agccttgagt   3420

tacggtgttt attttccaat caagtgaaga tatctcctac ttctcctact ggaacatctc   3480

agcttctgca gtgaagaaaa attcctgtga tagttcagtt ctttagtttt tctatttgaa   3540

aaaaaaaaat catttaaatg atcctttgtt cacggctctc cttaatgact gagtgaacag   3600

ttcctatctg tatatttgac taaacctttt cctaagctat ctctcatggt tcctatgttt   3660

ttttatcata attaaaagca aaaccatctg gatcacctaa cagtcagagg tcagtatctc   3720

agcgtgtgaa ttatagagga aatacagaga gaacctcttc cacttttact tttcgtccaa   3780

ataaaatgca tggtgtacca gaagttgaag atcgggttga ggattggggc tagctcgatg   3840

acactaaggc cccaacatcg cgggacctgc tgtggcgcgg attcttagga acgctgttct   3900

agccggcccc ctctccaggg gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac   3960

cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc aacctctgac   4020

gttctgcgcc ttcctaggag agtcttacat gtgttgagat ttcacaagca atgcgagttg   4080

taaaatacca gctctacaag aagctaggct ctgtgacggc atagttttca gtagctttat   4140

cacaatattc acaatggaga attatatgac atggtagcag aaataggccc ttttatgtgt   4200

tgcttctatt ttacctcaaa ttgtagatat agggtaatca ataaaatcca tccatgcctt   4260

tcacacacta agt                                                      4273


<210>  4299
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  4299

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg 
            420                 425                 430


Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe 
        435                 440                 445


Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val 
    450                 455                 460


Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile 
465                 470                 475                 480


Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
                485                 490


<210>  4300
<211>  5079
<212>  DNA
<213>  Homo sapiens

<400>  4300
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagctca   1980

agctcttgga ctcaccgagg cagtaaaagt accatatcct gtgtttgaat caaacccgga   2040

gttcttgtat gtggaaggct tgccagaggg gattcccttc cgaagcccta cctggtttgg   2100

aattccacga cttgaaagga tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa   2160

acctgaacta gttatttcct acttgcctcc tgggatggct agtaaaataa acactaaagc   2220

tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga   2280

ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc tcagctgttc gaaccccgac   2340

ccagactaac ggttctaacg ttcccttcaa gccacgaggg agagagtttt cctttgaggc   2400

ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa aatctcttca atgagaaatg   2460

tggggaagct cttggcctta aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt   2520

cccggaagac ttttatgtgg aaggcttacc tgagggtgtg ccattccgaa gaccatcgac   2580

ttttggcatt ccgaggctgg agaagatact cagaaacaaa gccaaaatta agttcatcat   2640

taaaaagccc gaaatgtttg agacggcgat taaggagagc acctcctcta agagccctcc   2700

cagaaaaata aattcatcac ccaatgttaa tactactgca tcaggtgttg aagaccttaa   2760

catcattcag gtgacaattc cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc   2820

tagacagcta agagaacaag tgaatgacct ctttagtcgg aaatttggtg aagctattgg   2880

tatgggtttt cctgtgaaag ttccctacag gaaaatcaca attaaccctg gctgtgtggt   2940

ggttgatggc atgcccccgg gggtgtcctt caaagccccc agctacctgg aaatcagctc   3000

catgagaagg atcttagact ctgccgagtt tatcaaattc acggtcatta gaccatttcc   3060

aggacttgtg attaataacc agctggttga tcagagtgag tcagaaggcc ccgtgataca   3120

agaatcagct gaaccaagcc agttggaagt tccagccaca gaagaaataa aagagactga   3180

tggaagctct cagatcaagc aagaaccaga ccccacgtgg tagacctctt ccctcctagg   3240

gtaaatcagc ttctgtgtca gggatgctgt gtggtgtcca tctgaacccc ctgcatacgc   3300

gtagctaatg tgatctcccc actttcacat aagatggtgg ccctgccttc agggaatgtg   3360

ggagccaggt gggagccttc ccggatattt aagctagaag attctacagg gagattctcc   3420

ttggatcaat atatgtctct cagtcaaaga tgtaaaagca cttttgcctt aaaaagaatg   3480

ttctgtttct aaatagagtc aacgttgtcc tcctcattgg aattcactat gagtcagaat   3540

cattagactg actttttttt ttccatagta atagtatttt gcagagtctc acagagctgc   3600

agatcttttg ttcatcttgc agagttaaca agtctgatcc tgttagtcca gatttcttaa   3660

atttggccaa gttataatag gagcagtagc ttgagacccg aagtcaggaa actttgacaa   3720

tggatttttt tttttaatcc agagacttgt actggaattt gccttaccct gtcagctcat   3780

ggacttaagg tttcatcccg ctttatgagt gcttctgaat ccaagtcatt gttacctgaa   3840

tttgcaaatt aagttgtgat attcgtgact gttaaattcc tgtaattaga ttaacctctt   3900

tgcttgcttg tttgttttct ctcctatttt agcttaaagt atcagtggtt gagaagagct   3960

tttcggacct gttactaccc caagctgtgt aatatacttg tataacagaa ataccttcta   4020

tacaaacctt tttttctact tttagataga aatgtctact ttttcagcag ttctgtgaat   4080

taaagagcag agtgactgtg ggtctggaat ggctggtgta cttgggaatg tactatcagg   4140

attttacagc aatgctggga aatgacaggg aaaatgacag gaatgaatct caccagattt   4200

tttatgtact cagcagagcc ttgagttacg gtgtttattt tccaatcaag tgaagatatc   4260

tcctacttct cctactggaa catctcagct tctgcagtga agaaaaattc ctgtgatagt   4320

tcagttcttt agtttttcta tttgaaaaaa aaaaatcatt taaatgatcc tttgttcacg   4380

gctctcctta atgactgagt gaacagttcc tatctgtata tttgactaaa ccttttccta   4440

agctatctct catggttcct atgttttttt atcataatta aaagcaaaac catctggatc   4500

acctaacagt cagaggtcag tatctcagcg tgtgaattat agaggaaata cagagagaac   4560

ctcttccact tttacttttc gtccaaataa aatgcatggt gtaccagaag ttgaagatcg   4620

ggttgaggat tggggctagc tcgatgacac taaggcccca acatcgcggg acctgctgtg   4680

gcgcggattc ttaggaacgc tgttctagcc ggccccctct ccaggggtcg ccgtggccgg   4740

cattatttcc tagttcttct tgtaaccctg aggtgccagc gcggggagtg aggaggggtc   4800

agggggctaa ggatgcaacc tctgacgttc tgcgccttcc taggagagtc ttacatgtgt   4860

tgagatttca caagcaatgc gagttgtaaa ataccagctc tacaagaagc taggctctgt   4920

gacggcatag ttttcagtag ctttatcaca atattcacaa tggagaatta tatgacatgg   4980

tagcagaaat aggccctttt atgtgttgct tctattttac ctcaaattgt agatataggg   5040

taatcaataa aatccatcca tgcctttcac acactaagt                          5079


<210>  4301
<211>  933
<212>  PRT
<213>  Homo sapiens

<400>  4301

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
        515                 520                 525


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
    530                 535                 540


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
545                 550                 555                 560


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
                565                 570                 575


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
            580                 585                 590


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
        595                 600                 605


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
    610                 615                 620


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
625                 630                 635                 640


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
                645                 650                 655


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
            660                 665                 670


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
        675                 680                 685


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
    690                 695                 700


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
705                 710                 715                 720


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
                725                 730                 735


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
            740                 745                 750


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
        755                 760                 765


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
    770                 775                 780


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
785                 790                 795                 800


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
                805                 810                 815


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
            820                 825                 830


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
        835                 840                 845


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
    850                 855                 860


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro 
865                 870                 875                 880


Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly 
                885                 890                 895


Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala 
            900                 905                 910


Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu 
        915                 920                 925


Pro Asp Pro Thr Trp 
    930


<210>  4302
<211>  4231
<212>  DNA
<213>  Homo sapiens

<400>  4302
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   1980

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2040

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2100

atcaaacccg gagttcttgt atgtggaagg cttgccagag gggattccct tccgaagccc   2160

tacctggttt ggaattccac gacttgaaag gatcgtccgc gggagtaata aaatcaagtt   2220

cgttgttaaa aaacctgaac tagttatttc ctacttgcct cctgggatgg ctagtaaaat   2280

aaacactaaa gctttgcagt cccccaaaag accacgaagt cctgggagta attcaaaggt   2340

tcctgaaatt gaggtcaccg tggaaggccc taataacaac aatcctcaaa cctcagctgt   2400

tcgaaccccg acccagacta acggttctaa cgttcccttc aagccacgag ggagagagtt   2460

ttcctttgag gcctggaatg ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt   2520

caatgagaaa tgtggggaag ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt   2580

atttgagtct ttcccggaag acttttatgt ggaaggctta cctgagggtg tgccattccg   2640

aagaccatcg acttttggca ttccgaggct ggagaagata ctcagaaaca aagccaaaat   2700

taagttcatc attaaaaagc ccgaaatgtt tgagacggcg attaaggaga gcacctcctc   2760

taagagccct cccagaaaaa taaattcatc acccaatgtt aatactactg catcaggtgt   2820

tgaagacctt aacatcattc aggtgacaat tccagatgat gataatgaaa gactctcgaa   2880

agttgaaaaa gctagacagc taagagaaca agtgaatgac ctctttagtc ggaaatttgg   2940

tgaagctatt ggtatgggtt ttcctgtgaa agttccctac aggaaaatca caattaaccc   3000

tggctgtgtg gtggttgatg gcatgccccc gggggtgtcc ttcaaagccc ccagctacct   3060

ggaaatcagc tccatgagaa ggatcttaga ctctgccgag tttatcaaat tcacggtcat   3120

tagaccattt ccaggacttg tgattaataa ccagctggtt gatcagagtg agtcagaagg   3180

ccccgtgata caagaatcag ctgaaccaag ccagttggaa gttccagcca cagaagaaat   3240

aaaagagact gatggaagct ctcagatcaa gcaagaacca gaccccacgt ggtagacctc   3300

ttccctccta ggcttaaagt atcagtggtt gagaagagct tttcggacct gttactaccc   3360

caagctgtag ccttgagtta cggtgtttat tttccaatca agtgaagata tctcctactt   3420

ctcctactgg aacatctcag cttctgcagt gaagaaaaat tcctgtgata gttcagttct   3480

ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat cctttgttca cggctctcct   3540

taatgactga gtgaacagtt cctatctgta tatttgacta aaccttttcc taagctatct   3600

ctcatggttc ctatgttttt ttatcataat taaaagcaaa accatctgga tcacctaaca   3660

gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa tacagagaga acctcttcca   3720

cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga agttgaagat cgggttgagg   3780

attggggcta gctcgatgac actaaggccc caacatcgcg ggacctgctg tggcgcggat   3840

tcttaggaac gctgttctag ccggccccct ctccaggggt cgccgtggcc ggcattattt   3900

cctagttctt cttgtaaccc tgaggtgcca gcgcggggag tgaggagggg tcagggggct   3960

aaggatgcaa cctctgacgt tctgcgcctt cctaggagag tcttacatgt gttgagattt   4020

cacaagcaat gcgagttgta aaataccagc tctacaagaa gctaggctct gtgacggcat   4080

agttttcagt agctttatca caatattcac aatggagaat tatatgacat ggtagcagaa   4140

ataggccctt ttatgtgttg cttctatttt acctcaaatt gtagatatag ggtaatcaat   4200

aaaatccatc catgcctttc acacactaag t                                  4231


<210>  4303
<211>  957
<212>  PRT
<213>  Homo sapiens

<400>  4303

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
                565                 570                 575


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
            580                 585                 590


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
        595                 600                 605


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
    610                 615                 620


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
625                 630                 635                 640


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
                645                 650                 655


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
            660                 665                 670


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
        675                 680                 685


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
    690                 695                 700


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
705                 710                 715                 720


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
                725                 730                 735


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
            740                 745                 750


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
        755                 760                 765


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
    770                 775                 780


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
785                 790                 795                 800


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
                805                 810                 815


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
            820                 825                 830


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
        835                 840                 845


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
    850                 855                 860


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
865                 870                 875                 880


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
                885                 890                 895


Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu 
            900                 905                 910


Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu 
        915                 920                 925


Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp 
    930                 935                 940


Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950                 955


<210>  4304
<211>  7101
<212>  DNA
<213>  Homo sapiens

<400>  4304
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1860

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1920

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1980

aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc   2040

ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt   2100

tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa   2160

taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg   2220

ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg   2280

ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga gggagagagt   2340

tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct   2400

tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt   2460

tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc   2520

gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa   2580

ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct   2640

ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg   2700

ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga   2760

aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg   2820

gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc   2880

ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc   2940

tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca   3000

ttaggtaagt gagagtttcc tgcttagtca caggagcgaa tctggagctc atgaggctga   3060

ctcttctaaa atgcagccac aggtagtcat cgaatccggc ttcctatgct gtgcaatcaa   3120

caaatcaaaa taacttgtgt catcattaga atgtcagatg tgcttctacg aactaagctg   3180

actcttttaa ttctttggca aagggttggc aaactaggac tgtttgccaa attcaggctg   3240

cctcctattt ttagagtctt cctgaaacac agctacaccc gtattatcca tggctgcttt   3300

cctgtcacag tgagtaagta gctgggactg agaaggcatg gcctccaaag tctaaaatat   3360

ttactctcta gcactttgta gaaaaacctt agctaggcac agtggctaac gcctgtaatc   3420

ccagcatttt gggaggccaa ggcaggcaga tcacctgagg tcaggagttc cagaccagcc   3480

tggccaacat ggtgaaatcc catctctaca aaaataaaac agttagctgg gcatgatggc   3540

gggtgcctgt aatcccagct actcgggagg ctgaggcagg atagtcgctt gaacccagga   3600

ggtggaggtt gcaatgagcc aagatcatgc cactgcactc cagcctggac gacagagtga   3660

gactccatca caagaaaaaa agaactttgt caacctctgt cttagggcgc cttgtcacag   3720

gcttcgggtc agacggattc aaccttgcat cagccatttg ttagccaggt cactctgttc   3780

tttgtctgta aatgagattg atcgttgttc ccactgagag tgtcagctcc ttcccgtaga   3840

gcaggcatga tgattgtact cacctctgac accattgtga gtgccacatt ccttcccacg   3900

tccttgtcac tgtaagagat gcccacctga gcaccaaccc caggttatct tcccctttgt   3960

cttccagccc cccagaaaca gctacgactc aacctaccca atcatttcat catcagattg   4020

ccactgtctc tagttcaggt ctcttgggac tggcactcag aaatctcata ataaatcctc   4080

ttgaggcttc tcatacactc gtcttcttcc aatcttcttt ccctcaaaat ctcatatttt   4140

ggttccactt cacccaccgt cattctccat atcactccca ggagttaggc aaaaagcccc   4200

ttccgttctt ccgtatgtta aacttagaat cactctgttc cctgctctgc gtttctattt   4260

tttgtttttc ctccatttac tagtagctta acactttcta acagtgttct tattattgat   4320

acgtatctat ctcttccata agcttataag gtcacggata atacttctca ttgtagtacg   4380

taaatgacgt gggctagata tgagttgaat aaacagttat acctgtaaat tcttacagag   4440

tgaaaataaa ttgttatact ttacaatttg tttctctctt tagaccattt ccaggacttg   4500

tgattaataa ccgtgagtat tttgtgaagt gttttgtttt tgttttttcc tggggtctga   4560

cgtgtgtgcg tgtgagtgtg tatacatgct taacgtatat cacgttactt cacctatgtc   4620

agtaaccagg ccaaatactt gttttagccc tcagtaaaaa caccaggcac ttcctagttg   4680

taaaattatt caagcttctt aacttcctat cctcgatgca cttaatcata aaatggtaat   4740

aatagcaccg attttggggg agtcgttcca gtagatggaa agcatctgga acaggtgtca   4800

gcaagctcct gccgacgtgt atgcataaag ttttattgaa accaccatcg tgtccatttg   4860

tttatggcag aactgagaga tggcagcagc aagtgtgtgc ctgcaaaacc taaaatattt   4920

actaattggc tctgcaagaa aagagtttgc atccccctaa cctagaacag tgtctagcct   4980

ctagtatgtg tttagcctac agtatgtgct cagcgaatac aatctatatt tattactgct   5040

tttatgactg ttataattac tgtgcttgga tttcgttaca aagtaagtca caatgtgcct   5100

gcttctgtta gtatttcagc acagtgcctg gcacacatgg ggctctcaaa tattgctgag   5160

cgagtgaaca aatgtccttt caattcctta acgttgatgt cattttcaat agtattttga   5220

gccaaactta attttgcgag tgtgttttgt tttcttaact ttattattaa aaatgtataa   5280

aagtgaggcc aggcgtggtg gctcacgcct gtaatcccag cagtttggga ggctgaggca   5340

ggcggatcag ttgaggttgg gagttggaga ccagcccgtc caacatggtg aaagcctgtc   5400

tctactaaaa atacaaaaat cagctgggtg tggtggcgcg tgcctgtaat cccagctact   5460

caggaggctg aggcaggaga gttgcttgaa tcctagaggt ggaggttgca gtgagctgag   5520

atcgtgccat tgcactccag cctgggcaac aagagcaaaa ctctgtccca ataaataaat   5580

aaataaaatg ttctcttttg ttcctgttct tgtgcggtag tgtggtatag agttttatgg   5640

taattactgt gaattagtga ttctgaggga catatcagaa ctctgaggtt tgtttccttc   5700

tcatcttgag ggaaacagca aatgtatgtt aaaatgcttt tccaagggaa caacacatcc   5760

ttacattatt taaaccaatc tgcttcattt tcagagctgg ttgatcagag tgagtcagaa   5820

ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc cacagaagaa   5880

ataaaagaga ctgatggaag ctctcagatc aagcaagaac cagaccccac gtggtagacc   5940

tcttccctcc taggcttaaa gtatcagtgg ttgagaagag cttttcggac ctgttactac   6000

cccaagctgt gtaatatact tgtataacag aaataccttc tatacaaacc tttttttcta   6060

cttttagata gaaatgtcta ctttttcagc agttctgtga attaaagagc agagtgactg   6120

tgggtctgga atggctggtg tacttgggaa tgtactatca ggattttaca gcaatgctgg   6180

gaaatgacag ggaaaatgac aggaatgaat ctcaccagat tttttatgta ctcagcagag   6240

ccttgagtta cggtgtttat tttccaatca agtgaagata tctcctactt ctcctactgg   6300

aacatctcag cttctgcagt gaagaaaaat tcctgtgata gttcagttct ttagtttttc   6360

tatttgaaaa aaaaaaatca tttaaatgat cctttgttca cggctctcct taatgactga   6420

gtgaacagtt cctatctgta tatttgacta aaccttttcc taagctatct ctcatggttc   6480

ctatgttttt ttatcataat taaaagcaaa accatctgga tcacctaaca gtcagaggtc   6540

agtatctcag cgtgtgaatt atagaggaaa tacagagaga acctcttcca cttttacttt   6600

tcgtccaaat aaaatgcatg gtgtaccaga agttgaagat cgggttgagg attggggcta   6660

gctcgatgac actaaggccc caacatcgcg ggacctgctg tggcgcggat tcttaggaac   6720

gctgttctag ccggccccct ctccaggggt cgccgtggcc ggcattattt cctagttctt   6780

cttgtaaccc tgaggtgcca gcgcggggag tgaggagggg tcagggggct aaggatgcaa   6840

cctctgacgt tctgcgcctt cctaggagag tcttacatgt gttgagattt cacaagcaat   6900

gcgagttgta aaataccagc tctacaagaa gctaggctct gtgacggcat agttttcagt   6960

agctttatca caatattcac aatggagaat tatatgacat ggtagcagaa ataggccctt   7020

ttatgtgttg cttctatttt acctcaaatt gtagatatag ggtaatcaat aaaatccatc   7080

catgcctttc acacactaag t                                             7101


<210>  4305
<211>  807
<212>  PRT
<213>  Homo sapiens

<400>  4305

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg 
            420                 425                 430


Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe 
        435                 440                 445


Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val 
    450                 455                 460


Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly 
465                 470                 475                 480


Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg 
                485                 490                 495


Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu 
            500                 505                 510


Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr 
        515                 520                 525


Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser 
    530                 535                 540


Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn 
545                 550                 555                 560


Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn 
                565                 570                 575


Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn 
            580                 585                 590


Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu 
        595                 600                 605


Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe 
    610                 615                 620


Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro 
625                 630                 635                 640


Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu 
                645                 650                 655


Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys 
            660                 665                 670


Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser 
        675                 680                 685


Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser 
    690                 695                 700


Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp 
705                 710                 715                 720


Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln 
                725                 730                 735


Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly 
            740                 745                 750


Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys 
        755                 760                 765


Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser 
    770                 775                 780


Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe 
785                 790                 795                 800


Ile Lys Phe Thr Val Ile Arg 
                805


<210>  4306
<211>  4288
<212>  DNA
<213>  Homo sapiens

<400>  4306
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1980

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   2040

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2100

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2160

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2220

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2280

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2340

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2400

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2460

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2520

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2580

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2640

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2700

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2760

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2820

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2880

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   2940

cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg atcagagtga   3000

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   3060

agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag accccacgtg   3120

gtagacctct tccctcctag gcttaaagta tcagtggttg agaagagctt ttcggacctg   3180

ttactacccc aagctgtgta atatacttgt ataacagaaa taccttctat acaaaccttt   3240

ttttctactt ttagatagaa atgtctactt tttcagcagt tctgtgaatt aaagagcaga   3300

gtgactgtgg gtctggaatg gctggtgtac ttgggaatgt actatcagga ttttacagca   3360

atgctgggaa atgacaggga aaatgacagg aatgaatctc accagatttt ttatgtactc   3420

agcagagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct cctacttctc   3480

ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta   3540

gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg ctctccttaa   3600

tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa gctatctctc   3660

atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca cctaacagtc   3720

agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc tcttccactt   3780

ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg gttgaggatt   3840

ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg cgcggattct   3900

taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc attatttcct   3960

agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca gggggctaag   4020

gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt gagatttcac   4080

aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg acggcatagt   4140

tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt agcagaaata   4200

ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt aatcaataaa   4260

atccatccat gcctttcaca cactaagt                                      4288


<210>  4307
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  4307

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
            420                 425                 430


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
        435                 440                 445


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
    450                 455                 460


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser 
465                 470                 475                 480


Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
                485                 490                 495


<210>  4308
<211>  3978
<212>  DNA
<213>  Homo sapiens

<400>  4308
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   2040

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2100

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2160

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2220

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2280

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2340

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2400

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2460

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2520

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2580

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2640

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2700

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2760

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2820

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2880

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   2940

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   3000

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3060

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3120

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3180

ttcacggtca ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt   3240

gagtcagaag gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc   3300

acagaagaaa taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg   3360

tggtagacct cttccctcct aggcaaaacc atctggatca cctaacagtc agaggtcagt   3420

atctcagcgt gtgaattata gaggaaatac agagagaacc tcttccactt ttacttttcg   3480

tccaaataaa atgcatggtg taccagaagt tgaagatcgg gttgaggatt ggggctagct   3540

cgatgacact aaggccccaa catcgcggga cctgctgtgg cgcggattct taggaacgct   3600

gttctagccg gccccctctc caggggtcgc cgtggccggc attatttcct agttcttctt   3660

gtaaccctga ggtgccagcg cggggagtga ggaggggtca gggggctaag gatgcaacct   3720

ctgacgttct gcgccttcct aggagagtct tacatgtgtt gagatttcac aagcaatgcg   3780

agttgtaaaa taccagctct acaagaagct aggctctgtg acggcatagt tttcagtagc   3840

tttatcacaa tattcacaat ggagaattat atgacatggt agcagaaata ggccctttta   3900

tgtgttgctt ctattttacc tcaaattgta gatatagggt aatcaataaa atccatccat   3960

gcctttcaca cactaagt                                                 3978


<210>  4309
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  4309

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
    450                 455                 460


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
465                 470                 475


<210>  4310
<211>  4403
<212>  DNA
<213>  Homo sapiens

<400>  4310
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   2040

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2100

gaaatttgct tagatttgtt gacagcggtt tcctggagtg ctgtcttgag aacgattctg   2160

aggaggctca gcaagaaaga gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa   2220

ctcaagctct tggactcacc gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc   2280

cggagttctt gtatgtggaa ggcttgccag aggggattcc cttccgaagc cctacctggt   2340

ttggaattcc acgacttgaa aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta   2400

aaaaacctga actagttatt tcctacttgc ctcctgggat ggctagtaaa ataaacacta   2460

aagctttgca gtcccccaaa agaccacgaa gtcctgggag taattcaaag gttcctgaaa   2520

ttgaggtcac cgtggaaggc cctaataaca acaatcctca aacctcagct gttcgaaccc   2580

cgacccagac taacggttct aacgttccct tcaagccacg agggagagag ttttcctttg   2640

aggcctggaa tgccaaaatc acggacctaa aacagaaagt tgaaaatctc ttcaatgaga   2700

aatgtgggga agctcttggc cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt   2760

ctttcccgga agacttttat gtggaaggct tacctgaggg tgtgccattc cgaagaccat   2820

cgacttttgg cattccgagg ctggagaaga tactcagaaa caaagccaaa attaagttca   2880

tcattaaaaa gcccgaaatg tttgagacgg cgattaagga gagcacctcc tctaagagcc   2940

ctcccagaaa aataaattca tcacccaatg ttaatactac tgcatcaggt gttgaagacc   3000

ttaacatcat tcaggtgaca attccagatg atgataatga aagactctcg aaagttgaaa   3060

aagctagaca gctaagagaa caagtgaatg acctctttag tcggaaattt ggtgaagcta   3120

ttggtatggg ttttcctgtg aaagttccct acaggaaaat cacaattaac cctggctgtg   3180

tggtggttga tggcatgccc ccgggggtgt ccttcaaagc ccccagctac ctggaaatca   3240

gctccatgag aaggatctta gactctgccg agtttatcaa attcacggtc attagaccat   3300

ttccaggact tgtgattaat aaccagctgg ttgatcagag tgagtcagaa ggccccgtga   3360

tacaagaatc agctgaacca agccagttgg aagttccagc cacagaagaa ataaaagaga   3420

ctgatggaag ctctcagatc aagcaagaac cagaccccac gtggtagacc tcttccctcc   3480

taggcttaaa gtatcagtgg ttgagaagag cttttcggac ctgttactac cccaagctgt   3540

agccttgagt tacggtgttt attttccaat caagtgaaga tatctcctac ttctcctact   3600

ggaacatctc agcttctgca gtgaagaaaa attcctgtga tagttcagtt ctttagtttt   3660

tctatttgaa aaaaaaaaat catttaaatg atcctttgtt cacggctctc cttaatgact   3720

gagtgaacag ttcctatctg tatatttgac taaacctttt cctaagctat ctctcatggt   3780

tcctatgttt ttttatcata attaaaagca aaaccatctg gatcacctaa cagtcagagg   3840

tcagtatctc agcgtgtgaa ttatagagga aatacagaga gaacctcttc cacttttact   3900

tttcgtccaa ataaaatgca tggtgtacca gaagttgaag atcgggttga ggattggggc   3960

tagctcgatg acactaaggc cccaacatcg cgggacctgc tgtggcgcgg attcttagga   4020

acgctgttct agccggcccc ctctccaggg gtcgccgtgg ccggcattat ttcctagttc   4080

ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc   4140

aacctctgac gttctgcgcc ttcctaggag agtcttacat gtgttgagat ttcacaagca   4200

atgcgagttg taaaatacca gctctacaag aagctaggct ctgtgacggc atagttttca   4260

gtagctttat cacaatattc acaatggaga attatatgac atggtagcag aaataggccc   4320

ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat agggtaatca ataaaatcca   4380

tccatgcctt tcacacacta agt                                           4403


<210>  4311
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  4311

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala 



<210>  4312
<211>  4953
<212>  DNA
<213>  Homo sapiens

<400>  4312
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1920

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   1980

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttga   2040

aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg aactagttat   2100

ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc agtcccccaa   2160

aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg   2220

ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga ctaacggttc   2280

taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga atgccaaaat   2340

cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg   2400

ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg aagactttta   2460

tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg gcattccgag   2520

gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa agcccgaaat   2580

gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa aaataaattc   2640

atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca ttcaggtgac   2700

aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac agctaagaga   2760

acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg gttttcctgt   2820

gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg atggcatgcc   2880

cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga gaaggatctt   2940

agactctgcc gagtttatca aattcacggt cattagacca tttccaggac ttgtgattaa   3000

taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat cagctgaacc   3060

aagccagttg gaagttccag ccacagaagg taaaaggacc tcttccctcc tagggtaaat   3120

cagcttctgt gtcagggatg ctgtgtggtg tccatctgaa ccccctgcat acgcgtagct   3180

aatgtgatct ccccactttc acataagatg gtggccctgc cttcagggaa tgtgggagcc   3240

aggtgggagc cttcccggat atttaagcta gaagattcta cagggagatt ctccttggat   3300

caatatatgt ctctcagtca aagatgtaaa agcacttttg ccttaaaaag aatgttctgt   3360

ttctaaatag agtcaacgtt gtcctcctca ttggaattca ctatgagtca gaatcattag   3420

actgactttt ttttttccat agtaatagta ttttgcagag tctcacagag ctgcagatct   3480

tttgttcatc ttgcagagtt aacaagtctg atcctgttag tccagatttc ttaaatttgg   3540

ccaagttata ataggagcag tagcttgaga cccgaagtca ggaaactttg acaatggatt   3600

ttttttttta atccagagac ttgtactgga atttgcctta ccctgtcagc tcatggactt   3660

aaggtttcat cccgctttat gagtgcttct gaatccaagt cattgttacc tgaatttgca   3720

aattaagttg tgatattcgt gactgttaaa ttcctgtaat tagattaacc tctttgcttg   3780

cttgtttgtt ttctctccta ttttagctta aagtatcagt ggttgagaag agcttttcgg   3840

acctgttact accccaagct gtgtaatata cttgtataac agaaatacct tctatacaaa   3900

cctttttttc tacttttaga tagaaatgtc tactttttca gcagttctgt gaattaaaga   3960

gcagagtgac tgtgggtctg gaatggctgg tgtacttggg aatgtactat caggatttta   4020

cagcaatgct gggaaatgac agggaaaatg acaggaatga atctcaccag attttttatg   4080

tactcagcag agccttgagt tacggtgttt attttccaat caagtgaaga tatctcctac   4140

ttctcctact ggaacatctc agcttctgca gtgaagaaaa attcctgtga tagttcagtt   4200

ctttagtttt tctatttgaa aaaaaaaaat catttaaatg atcctttgtt cacggctctc   4260

cttaatgact gagtgaacag ttcctatctg tatatttgac taaacctttt cctaagctat   4320

ctctcatggt tcctatgttt ttttatcata attaaaagca aaaccatctg gatcacctaa   4380

cagtcagagg tcagtatctc agcgtgtgaa ttatagagga aatacagaga gaacctcttc   4440

cacttttact tttcgtccaa ataaaatgca tggtgtacca gaagttgaag atcgggttga   4500

ggattggggc tagctcgatg acactaaggc cccaacatcg cgggacctgc tgtggcgcgg   4560

attcttagga acgctgttct agccggcccc ctctccaggg gtcgccgtgg ccggcattat   4620

ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg   4680

ctaaggatgc aacctctgac gttctgcgcc ttcctaggag agtcttacat gtgttgagat   4740

ttcacaagca atgcgagttg taaaatacca gctctacaag aagctaggct ctgtgacggc   4800

atagttttca gtagctttat cacaatattc acaatggaga attatatgac atggtagcag   4860

aaataggccc ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat agggtaatca   4920

ataaaatcca tccatgcctt tcacacacta agt                                4953


<210>  4313
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  4313

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
            500                 505                 510


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
        515                 520                 525


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
    530                 535                 540


Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu 
545                 550                 555                 560


Lys Asn Leu Asn 



<210>  4314
<211>  4298
<212>  DNA
<213>  Homo sapiens

<400>  4314
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2100

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2160

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2220

tgaatcaaac ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag   2280

ccctacctgg tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa   2340

gttcgttgtt aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa   2400

aataaacact aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa   2460

ggttcctgaa attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc   2520

tgttcgaacc ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga   2580

gttttccttt gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct   2640

cttcaatgag aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc   2700

gttatttgag tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt   2760

ccgaagacca tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa   2820

aattaagttc atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc   2880

ctctaagagc cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg   2940

tgttgaagac cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc   3000

gaaagttgaa aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt   3060

tggtgaagct attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa   3120

ccctggctgt gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta   3180

cctggaaatc agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt   3240

cattagacca tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga   3300

aggccccgtg atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga   3360

aataaaagag actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac   3420

ctcttccctc ctaggagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct   3480

cctacttctc ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt   3540

cagttcttta gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg   3600

ctctccttaa tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa   3660

gctatctctc atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca   3720

cctaacagtc agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc   3780

tcttccactt ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg   3840

gttgaggatt ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg   3900

cgcggattct taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc   3960

attatttcct agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca   4020

gggggctaag gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt   4080

gagatttcac aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg   4140

acggcatagt tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt   4200

agcagaaata ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt   4260

aatcaataaa atccatccat gcctttcaca cactaagt                           4298


<210>  4315
<211>  998
<212>  PRT
<213>  Homo sapiens

<400>  4315

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr 
        595                 600                 605


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe 
    610                 615                 620


Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys 
625                 630                 635                 640


Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly 
                645                 650                 655


Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro 
            660                 665                 670


Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val 
        675                 680                 685


Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro 
    690                 695                 700


Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu 
705                 710                 715                 720


Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys 
                725                 730                 735


Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys 
            740                 745                 750


Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp 
        755                 760                 765


Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser 
    770                 775                 780


Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys 
785                 790                 795                 800


Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys 
                805                 810                 815


Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro 
            820                 825                 830


Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln 
        835                 840                 845


Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys 
    850                 855                 860


Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe 
865                 870                 875                 880


Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys 
                885                 890                 895


Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly 
            900                 905                 910


Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg 
        915                 920                 925


Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe 
    930                 935                 940


Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu 
945                 950                 955                 960


Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro 
                965                 970                 975


Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln 
            980                 985                 990


Glu Pro Asp Pro Thr Trp 
        995


<210>  4316
<211>  4452
<212>  DNA
<213>  Homo sapiens

<400>  4316
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1860

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1920

tgaaatttgc ttagatttgt tgacagcggt ttcctggagt gctgtcttga gaacgattct   1980

gaggaggctc agcaagaaag agtgtttcag ttgattgggt gtgtctgtca tggagaagga   2040

actcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac   2100

ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg   2160

tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2220

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2280

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2340

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2400

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2460

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2520

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2580

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2640

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2700

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2760

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2820

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2880

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2940

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   3000

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3060

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca   3120

tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg   3180

atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag   3240

actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc   3300

ctaggcttaa agtatcagtg gttgagaaga gcttttcgga cctgttacta ccccaagctg   3360

tgtaatatac ttgtataaca gaaatacctt ctatacaaac ctttttttct acttttagat   3420

agaaatgtct actttttcag cagttctgtg aattaaagag cagagtgact gtgggtctgg   3480

aatggctggt gtacttggga atgtactatc aggattttac agcaatgctg ggaaatgaca   3540

gggaaaatga caggaatgaa tctcaccaga ttttttatgt actcagcaga gccttgagtt   3600

acggtgttta ttttccaatc aagtgaagat atctcctact tctcctactg gaacatctca   3660

gcttctgcag tgaagaaaaa ttcctgtgat agttcagttc tttagttttt ctatttgaaa   3720

aaaaaaaatc atttaaatga tcctttgttc acggctctcc ttaatgactg agtgaacagt   3780

tcctatctgt atatttgact aaaccttttc ctaagctatc tctcatggtt cctatgtttt   3840

tttatcataa ttaaaagcaa aaccatctgg atcacctaac agtcagaggt cagtatctca   3900

gcgtgtgaat tatagaggaa atacagagag aacctcttcc acttttactt ttcgtccaaa   3960

taaaatgcat ggtgtaccag aagttgaaga tcgggttgag gattggggct agctcgatga   4020

cactaaggcc ccaacatcgc gggacctgct gtggcgcgga ttcttaggaa cgctgttcta   4080

gccggccccc tctccagggg tcgccgtggc cggcattatt tcctagttct tcttgtaacc   4140

ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc taaggatgca acctctgacg   4200

ttctgcgcct tcctaggaga gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt   4260

aaaataccag ctctacaaga agctaggctc tgtgacggca tagttttcag tagctttatc   4320

acaatattca caatggagaa ttatatgaca tggtagcaga aataggccct tttatgtgtt   4380

gcttctattt tacctcaaat tgtagatata gggtaatcaa taaaatccat ccatgccttt   4440

cacacactaa gt                                                       4452


<210>  4317
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  4317

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg 
            420                 425                 430


Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe 
        435                 440                 445


Ala 



<210>  4318
<211>  4297
<212>  DNA
<213>  Homo sapiens

<400>  4318
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gtcaaagaag attggaatgt cagaattacc aagctacgga   1920

agcaagtgga agagattttt aatttgaaat ttgctcaagc tcttggactc accgaggcag   1980

taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgaaagga tcgtccgcgg   2040

gagtaataaa atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc   2100

tgggatggct agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc   2160

tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa   2220

tcctcaaacc tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa   2280

gccacgaggg agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca   2340

gaaagttgaa aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt   2400

gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc   2460

tgagggtgtg ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact   2520

cagaaacaaa gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat   2580

taaggagagc acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa   2640

tactactgca tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga   2700

taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct   2760

ctttagtcgg aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag   2820

gaaaatcaca attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt   2880

caaagccccc agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt   2940

tatcaaattc acggtcatta gaccatttcc aggacttgtg attaataacc agctggttga   3000

tcagagtgag tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt   3060

tccagccaca gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga   3120

ccccacgtgg tagacctctt ccctcctagg cttaaagtat cagtggttga gaagagcttt   3180

tcggacctgt tactacccca agctgtgtaa tatacttgta taacagaaat accttctata   3240

caaacctttt tttctacttt tagatagaaa tgtctacttt ttcagcagtt ctgtgaatta   3300

aagagcagag tgactgtggg tctggaatgg ctggtgtact tgggaatgta ctatcaggat   3360

tttacagcaa tgctgggaaa tgacagggaa aatgacagga atgaatctca ccagattttt   3420

tatgtactca gcagagcctt gagttacggt gtttattttc caatcaagtg aagatatctc   3480

ctacttctcc tactggaaca tctcagcttc tgcagtgaag aaaaattcct gtgatagttc   3540

agttctttag tttttctatt tgaaaaaaaa aaatcattta aatgatcctt tgttcacggc   3600

tctccttaat gactgagtga acagttccta tctgtatatt tgactaaacc ttttcctaag   3660

ctatctctca tggttcctat gtttttttat cataattaaa agcaaaacca tctggatcac   3720

ctaacagtca gaggtcagta tctcagcgtg tgaattatag aggaaataca gagagaacct   3780

cttccacttt tacttttcgt ccaaataaaa tgcatggtgt accagaagtt gaagatcggg   3840

ttgaggattg gggctagctc gatgacacta aggccccaac atcgcgggac ctgctgtggc   3900

gcggattctt aggaacgctg ttctagccgg ccccctctcc aggggtcgcc gtggccggca   3960

ttatttccta gttcttcttg taaccctgag gtgccagcgc ggggagtgag gaggggtcag   4020

ggggctaagg atgcaacctc tgacgttctg cgccttccta ggagagtctt acatgtgttg   4080

agatttcaca agcaatgcga gttgtaaaat accagctcta caagaagcta ggctctgtga   4140

cggcatagtt ttcagtagct ttatcacaat attcacaatg gagaattata tgacatggta   4200

gcagaaatag gcccttttat gtgttgcttc tattttacct caaattgtag atatagggta   4260

atcaataaaa tccatccatg cctttcacac actaagt                            4297


<210>  4319
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  4319

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
                485                 490                 495


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
            500                 505                 510


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
        515                 520                 525


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser 
    530                 535                 540


Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
545                 550                 555


<210>  4320
<211>  3900
<212>  DNA
<213>  Homo sapiens

<400>  4320
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1860

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1920

tgaaatttgc ttagatttgt tgacagcggt ttcctggagt gctgtcttga gaacgattct   1980

gaggaggctc agcaagaaag agtgtttcag ttgattgggt gtgtctgtca tggagaagga   2040

actcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac   2100

ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg   2160

tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2220

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2280

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2340

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2400

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2460

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2520

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2580

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2640

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2700

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2760

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2820

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2880

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2940

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   3000

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3060

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca   3120

tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg   3180

atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag   3240

actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc   3300

ctaggcaaaa ccatctggat cacctaacag tcagaggtca gtatctcagc gtgtgaatta   3360

tagaggaaat acagagagaa cctcttccac ttttactttt cgtccaaata aaatgcatgg   3420

tgtaccagaa gttgaagatc gggttgagga ttggggctag ctcgatgaca ctaaggcccc   3480

aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg ctgttctagc cggccccctc   3540

tccaggggtc gccgtggccg gcattatttc ctagttcttc ttgtaaccct gaggtgccag   3600

cgcggggagt gaggaggggt cagggggcta aggatgcaac ctctgacgtt ctgcgccttc   3660

ctaggagagt cttacatgtg ttgagatttc acaagcaatg cgagttgtaa aataccagct   3720

ctacaagaag ctaggctctg tgacggcata gttttcagta gctttatcac aatattcaca   3780

atggagaatt atatgacatg gtagcagaaa taggcccttt tatgtgttgc ttctatttta   3840

cctcaaattg tagatatagg gtaatcaata aaatccatcc atgcctttca cacactaagt   3900


<210>  4321
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  4321

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg 
            420                 425                 430


Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe 
        435                 440                 445


Ala 



<210>  4322
<211>  3740
<212>  DNA
<213>  Homo sapiens

<400>  4322
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gctcaagctc ttggactcac cgaggcagta aaagtaccat   1920

atcctgtgtt tgaatcaaac ccggagttct tgtatgtgga aggcttgcca gaggggattc   1980

ccttccgaag ccctacctgg tttggaattc cacgacttga aaggatcgtc cgcgggagta   2040

ataaaatcaa gttcgttgtt aaaaaacctg aactagttat ttcctacttg cctcctggga   2100

tggctagtaa aataaacact aaagctttgc agtcccccaa aagaccacga agtcctggga   2160

gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg ccctaataac aacaatcctc   2220

aaacctcagc tgttcgaacc ccgacccaga ctaacggttc taacgttccc ttcaagccac   2280

gagggagaga gttttccttt gaggcctgga atgccaaaat cacggaccta aaacagaaag   2340

ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg   2400

tgccgttcgc gttatttgag tctttcccgg aagactttta tgtggaaggc ttacctgagg   2460

gtgtgccatt ccgaagacca tcgacttttg gcattccgag gctggagaag atactcagaa   2520

acaaagccaa aattaagttc atcattaaaa agcccgaaat gtttgagacg gcgattaagg   2580

agagcacctc ctctaagagc cctcccagaa aaataaattc atcacccaat gttaatacta   2640

ctgcatcagg tgttgaagac cttaacatca ttcaggtgac aattccagat gatgataatg   2700

aaagactctc gaaagttgaa aaagctagac agctaagaga acaagtgaat gacctcttta   2760

gtcggaaatt tggtgaagct attggtatgg gttttcctgt gaaagttccc tacaggaaaa   2820

tcacaattaa ccctggctgt gtggtggttg atggcatgcc cccgggggtg tccttcaaag   2880

cccccagcta cctggaaatc agctccatga gaaggatctt agactctgcc gagtttatca   2940

aattcacggt cattagacca tttccaggac ttgtgattaa taaccagctg gttgatcaga   3000

gtgagtcaga aggccccgtg atacaagaat cagctgaacc aagccagttg gaagttccag   3060

ccacagaaga aataaaagag actgatggaa gctctcagat caagcaagaa ccagacccca   3120

cgtggtagac ctcttccctc ctaggcaaaa ccatctggat cacctaacag tcagaggtca   3180

gtatctcagc gtgtgaatta tagaggaaat acagagagaa cctcttccac ttttactttt   3240

cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc gggttgagga ttggggctag   3300

ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg   3360

ctgttctagc cggccccctc tccaggggtc gccgtggccg gcattatttc ctagttcttc   3420

ttgtaaccct gaggtgccag cgcggggagt gaggaggggt cagggggcta aggatgcaac   3480

ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg ttgagatttc acaagcaatg   3540

cgagttgtaa aataccagct ctacaagaag ctaggctctg tgacggcata gttttcagta   3600

gctttatcac aatattcaca atggagaatt atatgacatg gtagcagaaa taggcccttt   3660

tatgtgttgc ttctatttta cctcaaattg tagatatagg gtaatcaata aaatccatcc   3720

atgcctttca cacactaagt                                               3740


<210>  4323
<211>  908
<212>  PRT
<213>  Homo sapiens

<400>  4323

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala 
                485                 490                 495


Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser 
            500                 505                 510


Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        515                 520                 525


Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg 
    530                 535                 540


Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile 
545                 550                 555                 560


Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu 
                565                 570                 575


Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro 
            580                 585                 590


Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr 
        595                 600                 605


Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe 
    610                 615                 620


Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile 
625                 630                 635                 640


Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly 
                645                 650                 655


Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe 
            660                 665                 670


Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val 
        675                 680                 685


Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile 
    690                 695                 700


Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met 
705                 710                 715                 720


Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg 
                725                 730                 735


Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu 
            740                 745                 750


Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg 
        755                 760                 765


Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp 
    770                 775                 780


Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val 
785                 790                 795                 800


Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val 
                805                 810                 815


Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu 
            820                 825                 830


Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe 
        835                 840                 845


Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val 
    850                 855                 860


Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro 
865                 870                 875                 880


Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly 
                885                 890                 895


Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
            900                 905


<210>  4324
<211>  7107
<212>  DNA
<213>  Homo sapiens

<400>  4324
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   1980

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   2040

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2100

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2160

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2220

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2280

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2340

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2400

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2460

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2520

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2580

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2640

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2700

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2760

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2820

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2880

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   2940

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   3000

cggtcattag gtaagtgaga gtttcctgct tagtcacagg agcgaatctg gagctcatga   3060

ggctgactct tctaaaatgc agccacaggt agtcatcgaa tccggcttcc tatgctgtgc   3120

aatcaacaaa tcaaaataac ttgtgtcatc attagaatgt cagatgtgct tctacgaact   3180

aagctgactc ttttaattct ttggcaaagg gttggcaaac taggactgtt tgccaaattc   3240

aggctgcctc ctatttttag agtcttcctg aaacacagct acacccgtat tatccatggc   3300

tgctttcctg tcacagtgag taagtagctg ggactgagaa ggcatggcct ccaaagtcta   3360

aaatatttac tctctagcac tttgtagaaa aaccttagct aggcacagtg gctaacgcct   3420

gtaatcccag cattttggga ggccaaggca ggcagatcac ctgaggtcag gagttccaga   3480

ccagcctggc caacatggtg aaatcccatc tctacaaaaa taaaacagtt agctgggcat   3540

gatggcgggt gcctgtaatc ccagctactc gggaggctga ggcaggatag tcgcttgaac   3600

ccaggaggtg gaggttgcaa tgagccaaga tcatgccact gcactccagc ctggacgaca   3660

gagtgagact ccatcacaag aaaaaaagaa ctttgtcaac ctctgtctta gggcgccttg   3720

tcacaggctt cgggtcagac ggattcaacc ttgcatcagc catttgttag ccaggtcact   3780

ctgttctttg tctgtaaatg agattgatcg ttgttcccac tgagagtgtc agctccttcc   3840

cgtagagcag gcatgatgat tgtactcacc tctgacacca ttgtgagtgc cacattcctt   3900

cccacgtcct tgtcactgta agagatgccc acctgagcac caaccccagg ttatcttccc   3960

ctttgtcttc cagcccccca gaaacagcta cgactcaacc tacccaatca tttcatcatc   4020

agattgccac tgtctctagt tcaggtctct tgggactggc actcagaaat ctcataataa   4080

atcctcttga ggcttctcat acactcgtct tcttccaatc ttctttccct caaaatctca   4140

tattttggtt ccacttcacc caccgtcatt ctccatatca ctcccaggag ttaggcaaaa   4200

agccccttcc gttcttccgt atgttaaact tagaatcact ctgttccctg ctctgcgttt   4260

ctattttttg tttttcctcc atttactagt agcttaacac tttctaacag tgttcttatt   4320

attgatacgt atctatctct tccataagct tataaggtca cggataatac ttctcattgt   4380

agtacgtaaa tgacgtgggc tagatatgag ttgaataaac agttatacct gtaaattctt   4440

acagagtgaa aataaattgt tatactttac aatttgtttc tctctttaga ccatttccag   4500

gacttgtgat taataaccgt gagtattttg tgaagtgttt tgtttttgtt ttttcctggg   4560

gtctgacgtg tgtgcgtgtg agtgtgtata catgcttaac gtatatcacg ttacttcacc   4620

tatgtcagta accaggccaa atacttgttt tagccctcag taaaaacacc aggcacttcc   4680

tagttgtaaa attattcaag cttcttaact tcctatcctc gatgcactta atcataaaat   4740

ggtaataata gcaccgattt tgggggagtc gttccagtag atggaaagca tctggaacag   4800

gtgtcagcaa gctcctgccg acgtgtatgc ataaagtttt attgaaacca ccatcgtgtc   4860

catttgttta tggcagaact gagagatggc agcagcaagt gtgtgcctgc aaaacctaaa   4920

atatttacta attggctctg caagaaaaga gtttgcatcc ccctaaccta gaacagtgtc   4980

tagcctctag tatgtgttta gcctacagta tgtgctcagc gaatacaatc tatatttatt   5040

actgctttta tgactgttat aattactgtg cttggatttc gttacaaagt aagtcacaat   5100

gtgcctgctt ctgttagtat ttcagcacag tgcctggcac acatggggct ctcaaatatt   5160

gctgagcgag tgaacaaatg tcctttcaat tccttaacgt tgatgtcatt ttcaatagta   5220

ttttgagcca aacttaattt tgcgagtgtg ttttgttttc ttaactttat tattaaaaat   5280

gtataaaagt gaggccaggc gtggtggctc acgcctgtaa tcccagcagt ttgggaggct   5340

gaggcaggcg gatcagttga ggttgggagt tggagaccag cccgtccaac atggtgaaag   5400

cctgtctcta ctaaaaatac aaaaatcagc tgggtgtggt ggcgcgtgcc tgtaatccca   5460

gctactcagg aggctgaggc aggagagttg cttgaatcct agaggtggag gttgcagtga   5520

gctgagatcg tgccattgca ctccagcctg ggcaacaaga gcaaaactct gtcccaataa   5580

ataaataaat aaaatgttct cttttgttcc tgttcttgtg cggtagtgtg gtatagagtt   5640

ttatggtaat tactgtgaat tagtgattct gagggacata tcagaactct gaggtttgtt   5700

tccttctcat cttgagggaa acagcaaatg tatgttaaaa tgcttttcca agggaacaac   5760

acatccttac attatttaaa ccaatctgct tcattttcag agctggttga tcagagtgag   5820

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   5880

gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga ccccacgtgg   5940

tagacctctt ccctcctagg cttaaagtat cagtggttga gaagagcttt tcggacctgt   6000

tactacccca agctgtgtaa tatacttgta taacagaaat accttctata caaacctttt   6060

tttctacttt tagatagaaa tgtctacttt ttcagcagtt ctgtgaatta aagagcagag   6120

tgactgtggg tctggaatgg ctggtgtact tgggaatgta ctatcaggat tttacagcaa   6180

tgctgggaaa tgacagggaa aatgacagga atgaatctca ccagattttt tatgtactca   6240

gcagagcctt gagttacggt gtttattttc caatcaagtg aagatatctc ctacttctcc   6300

tactggaaca tctcagcttc tgcagtgaag aaaaattcct gtgatagttc agttctttag   6360

tttttctatt tgaaaaaaaa aaatcattta aatgatcctt tgttcacggc tctccttaat   6420

gactgagtga acagttccta tctgtatatt tgactaaacc ttttcctaag ctatctctca   6480

tggttcctat gtttttttat cataattaaa agcaaaacca tctggatcac ctaacagtca   6540

gaggtcagta tctcagcgtg tgaattatag aggaaataca gagagaacct cttccacttt   6600

tacttttcgt ccaaataaaa tgcatggtgt accagaagtt gaagatcggg ttgaggattg   6660

gggctagctc gatgacacta aggccccaac atcgcgggac ctgctgtggc gcggattctt   6720

aggaacgctg ttctagccgg ccccctctcc aggggtcgcc gtggccggca ttatttccta   6780

gttcttcttg taaccctgag gtgccagcgc ggggagtgag gaggggtcag ggggctaagg   6840

atgcaacctc tgacgttctg cgccttccta ggagagtctt acatgtgttg agatttcaca   6900

agcaatgcga gttgtaaaat accagctcta caagaagcta ggctctgtga cggcatagtt   6960

ttcagtagct ttatcacaat attcacaatg gagaattata tgacatggta gcagaaatag   7020

gcccttttat gtgttgcttc tattttacct caaattgtag atatagggta atcaataaaa   7080

tccatccatg cctttcacac actaagt                                       7107


<210>  4325
<211>  809
<212>  PRT
<213>  Homo sapiens

<400>  4325

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
    450                 455                 460


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
465                 470                 475                 480


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
                485                 490                 495


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
            500                 505                 510


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
        515                 520                 525


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
    530                 535                 540


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
545                 550                 555                 560


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
                565                 570                 575


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
            580                 585                 590


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
        595                 600                 605


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
    610                 615                 620


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
625                 630                 635                 640


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
                645                 650                 655


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
            660                 665                 670


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
        675                 680                 685


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
    690                 695                 700


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
705                 710                 715                 720


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
                725                 730                 735


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
            740                 745                 750


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
        755                 760                 765


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
    770                 775                 780


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
785                 790                 795                 800


Glu Phe Ile Lys Phe Thr Val Ile Arg 
                805


<210>  4326
<211>  4226
<212>  DNA
<213>  Homo sapiens

<400>  4326
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagc   2100

tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc   2160

ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc ctacctggtt   2220

tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa   2280

aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa taaacactaa   2340

agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg ttcctgaaat   2400

tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg ttcgaacccc   2460

gacccagact aacggttcta acgttccctt caagccacga gggagagagt tttcctttga   2520

ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct tcaatgagaa   2580

atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc   2640

tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc gaagaccatc   2700

gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa ttaagttcat   2760

cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct ctaagagccc   2820

tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg ttgaagacct   2880

taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga aagttgaaaa   2940

agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg gtgaagctat   3000

tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc ctggctgtgt   3060

ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc tggaaatcag   3120

ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca ttagaccatt   3180

tccaggactt gtgattaata accagctggt tgatcagagt gagtcagaag gccccgtgat   3240

acaagaatca gctgaaccaa gccagttgga agttccagcc acagaagaaa taaaagagac   3300

tgatggaagc tctcagatca agcaagaacc agaccccacg tggtagacct cttccctcct   3360

aggagccttg agttacggtg tttattttcc aatcaagtga agatatctcc tacttctcct   3420

actggaacat ctcagcttct gcagtgaaga aaaattcctg tgatagttca gttctttagt   3480

ttttctattt gaaaaaaaaa aatcatttaa atgatccttt gttcacggct ctccttaatg   3540

actgagtgaa cagttcctat ctgtatattt gactaaacct tttcctaagc tatctctcat   3600

ggttcctatg tttttttatc ataattaaaa gcaaaaccat ctggatcacc taacagtcag   3660

aggtcagtat ctcagcgtgt gaattataga ggaaatacag agagaacctc ttccactttt   3720

acttttcgtc caaataaaat gcatggtgta ccagaagttg aagatcgggt tgaggattgg   3780

ggctagctcg atgacactaa ggccccaaca tcgcgggacc tgctgtggcg cggattctta   3840

ggaacgctgt tctagccggc cccctctcca ggggtcgccg tggccggcat tatttcctag   3900

ttcttcttgt aaccctgagg tgccagcgcg gggagtgagg aggggtcagg gggctaagga   3960

tgcaacctct gacgttctgc gccttcctag gagagtctta catgtgttga gatttcacaa   4020

gcaatgcgag ttgtaaaata ccagctctac aagaagctag gctctgtgac ggcatagttt   4080

tcagtagctt tatcacaata ttcacaatgg agaattatat gacatggtag cagaaatagg   4140

cccttttatg tgttgcttct attttacctc aaattgtaga tatagggtaa tcaataaaat   4200

ccatccatgc ctttcacaca ctaagt                                        4226


<210>  4327
<211>  974
<212>  PRT
<213>  Homo sapiens

<400>  4327

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala 
545                 550                 555                 560


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
                565                 570                 575


Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile 
            580                 585                 590


Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile 
        595                 600                 605


Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu 
    610                 615                 620


Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys 
625                 630                 635                 640


Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys 
                645                 650                 655


Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro 
            660                 665                 670


Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val 
        675                 680                 685


Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala 
    690                 695                 700


Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys 
705                 710                 715                 720


Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala 
                725                 730                 735


Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu 
            740                 745                 750


Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu 
        755                 760                 765


Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro 
    770                 775                 780


Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro 
785                 790                 795                 800


Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly 
                805                 810                 815


Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn 
            820                 825                 830


Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val 
        835                 840                 845


Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe 
    850                 855                 860


Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val 
865                 870                 875                 880


Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr 
                885                 890                 895


Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile 
            900                 905                 910


Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln 
        915                 920                 925


Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala 
    930                 935                 940


Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr 
945                 950                 955                 960


Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
                965                 970


<210>  4328
<211>  5110
<212>  DNA
<213>  Homo sapiens

<400>  4328
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040

taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2100

ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2160

ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2220

ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2280

ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2340

atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2400

agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2460

agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2520

tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2580

ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2640

tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2700

ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2760

atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2820

ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2880

tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   2940

ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   3000

tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3060

ttatcaaatt cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg   3120

atcagagtga gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag   3180

ttccagccac agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag   3240

accccacgtg gtagacctct tccctcctag ggtaaatcag cttctgtgtc agggatgctg   3300

tgtggtgtcc atctgaaccc cctgcatacg cgtagctaat gtgatctccc cactttcaca   3360

taagatggtg gccctgcctt cagggaatgt gggagccagg tgggagcctt cccggatatt   3420

taagctagaa gattctacag ggagattctc cttggatcaa tatatgtctc tcagtcaaag   3480

atgtaaaagc acttttgcct taaaaagaat gttctgtttc taaatagagt caacgttgtc   3540

ctcctcattg gaattcacta tgagtcagaa tcattagact gacttttttt tttccatagt   3600

aatagtattt tgcagagtct cacagagctg cagatctttt gttcatcttg cagagttaac   3660

aagtctgatc ctgttagtcc agatttctta aatttggcca agttataata ggagcagtag   3720

cttgagaccc gaagtcagga aactttgaca atggattttt ttttttaatc cagagacttg   3780

tactggaatt tgccttaccc tgtcagctca tggacttaag gtttcatccc gctttatgag   3840

tgcttctgaa tccaagtcat tgttacctga atttgcaaat taagttgtga tattcgtgac   3900

tgttaaattc ctgtaattag attaacctct ttgcttgctt gtttgttttc tctcctattt   3960

tagcttaaag tatcagtggt tgagaagagc ttttcggacc tgttactacc ccaagctgtg   4020

taatatactt gtataacaga aataccttct atacaaacct ttttttctac ttttagatag   4080

aaatgtctac tttttcagca gttctgtgaa ttaaagagca gagtgactgt gggtctggaa   4140

tggctggtgt acttgggaat gtactatcag gattttacag caatgctggg aaatgacagg   4200

gaaaatgaca ggaatgaatc tcaccagatt ttttatgtac tcagcagagc cttgagttac   4260

ggtgtttatt ttccaatcaa gtgaagatat ctcctacttc tcctactgga acatctcagc   4320

ttctgcagtg aagaaaaatt cctgtgatag ttcagttctt tagtttttct atttgaaaaa   4380

aaaaaatcat ttaaatgatc ctttgttcac ggctctcctt aatgactgag tgaacagttc   4440

ctatctgtat atttgactaa accttttcct aagctatctc tcatggttcc tatgtttttt   4500

tatcataatt aaaagcaaaa ccatctggat cacctaacag tcagaggtca gtatctcagc   4560

gtgtgaatta tagaggaaat acagagagaa cctcttccac ttttactttt cgtccaaata   4620

aaatgcatgg tgtaccagaa gttgaagatc gggttgagga ttggggctag ctcgatgaca   4680

ctaaggcccc aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg ctgttctagc   4740

cggccccctc tccaggggtc gccgtggccg gcattatttc ctagttcttc ttgtaaccct   4800

gaggtgccag cgcggggagt gaggaggggt cagggggcta aggatgcaac ctctgacgtt   4860

ctgcgccttc ctaggagagt cttacatgtg ttgagatttc acaagcaatg cgagttgtaa   4920

aataccagct ctacaagaag ctaggctctg tgacggcata gttttcagta gctttatcac   4980

aatattcaca atggagaatt atatgacatg gtagcagaaa taggcccttt tatgtgttgc   5040

ttctatttta cctcaaattg tagatatagg gtaatcaata aaatccatcc atgcctttca   5100

cacactaagt                                                          5110


<210>  4329
<211>  889
<212>  PRT
<213>  Homo sapiens

<400>  4329

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
    450                 455                 460


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
465                 470                 475                 480


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
                485                 490                 495


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
            500                 505                 510


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
        515                 520                 525


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
    530                 535                 540


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
545                 550                 555                 560


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
                565                 570                 575


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
            580                 585                 590


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
        595                 600                 605


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
    610                 615                 620


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
625                 630                 635                 640


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
                645                 650                 655


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
            660                 665                 670


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
        675                 680                 685


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
    690                 695                 700


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
705                 710                 715                 720


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
                725                 730                 735


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
            740                 745                 750


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
        755                 760                 765


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
    770                 775                 780


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
785                 790                 795                 800


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
                805                 810                 815


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
            820                 825                 830


Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser 
        835                 840                 845


Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu 
    850                 855                 860


Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln 
865                 870                 875                 880


Ile Lys Gln Glu Pro Asp Pro Thr Trp 
                885


<210>  4330
<211>  4144
<212>  DNA
<213>  Homo sapiens

<400>  4330
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1980

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   2040

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttga   2100

aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg aactagttat   2160

ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc agtcccccaa   2220

aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg   2280

ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga ctaacggttc   2340

taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga atgccaaaat   2400

cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg   2460

ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg aagactttta   2520

tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg gcattccgag   2580

gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa agcccgaaat   2640

gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa aaataaattc   2700

atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca ttcaggtgac   2760

aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac agctaagaga   2820

acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg gttttcctgt   2880

gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg atggcatgcc   2940

cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga gaaggatctt   3000

agactctgcc gagtttatca aattcacggt cattagacca tttccaggac ttgtgattaa   3060

taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat cagctgaacc   3120

aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa gctctcagat   3180

caagcaagaa ccagacccca cgtggtagac ctcttccctc ctaggcttaa agtatcagtg   3240

gttgagaaga gcttttcgga cctgttacta ccccaagctg tagccttgag ttacggtgtt   3300

tattttccaa tcaagtgaag atatctccta cttctcctac tggaacatct cagcttctgc   3360

agtgaagaaa aattcctgtg atagttcagt tctttagttt ttctatttga aaaaaaaaaa   3420

tcatttaaat gatcctttgt tcacggctct ccttaatgac tgagtgaaca gttcctatct   3480

gtatatttga ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt tttttatcat   3540

aattaaaagc aaaaccatct ggatcaccta acagtcagag gtcagtatct cagcgtgtga   3600

attatagagg aaatacagag agaacctctt ccacttttac ttttcgtcca aataaaatgc   3660

atggtgtacc agaagttgaa gatcgggttg aggattgggg ctagctcgat gacactaagg   3720

ccccaacatc gcgggacctg ctgtggcgcg gattcttagg aacgctgttc tagccggccc   3780

cctctccagg ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa ccctgaggtg   3840

ccagcgcggg gagtgaggag gggtcagggg gctaaggatg caacctctga cgttctgcgc   3900

cttcctagga gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc   3960

agctctacaa gaagctaggc tctgtgacgg catagttttc agtagcttta tcacaatatt   4020

cacaatggag aattatatga catggtagca gaaataggcc cttttatgtg ttgcttctat   4080

tttacctcaa attgtagata tagggtaatc aataaaatcc atccatgcct ttcacacact   4140

aagt                                                                4144


<210>  4331
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  4331

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
                565                 570                 575


Ser Ser Leu Leu Lys Asn Leu Asn 
            580


<210>  4332
<211>  3825
<212>  DNA
<213>  Homo sapiens

<400>  4332
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gtcaaagaag attggaatgt   1980

cagaattacc aagctacgga agcaagtgga agagattttt aatttgaaat ttgctcaagc   2040

tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt   2100

cttgaaagga tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa acctgaacta   2160

gttatttcct acttgcctcc tgggatggct agtaaaataa acactaaagc tttgcagtcc   2220

cccaaaagac cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg   2280

gaaggcccta ataacaacaa tcctcaaacc tcagctgttc gaaccccgac ccagactaac   2340

ggttctaacg ttcccttcaa gccacgaggg agagagtttt cctttgaggc ctggaatgcc   2400

aaaatcacgg acctaaaaca gaaagttgaa aatctcttca atgagaaatg tggggaagct   2460

cttggcctta aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac   2520

ttttatgtgg aaggcttacc tgagggtgtg ccattccgaa gaccatcgac ttttggcatt   2580

ccgaggctgg agaagatact cagaaacaaa gccaaaatta agttcatcat taaaaagccc   2640

gaaatgtttg agacggcgat taaggagagc acctcctcta agagccctcc cagaaaaata   2700

aattcatcac ccaatgttaa tactactgca tcaggtgttg aagaccttaa catcattcag   2760

gtgacaattc cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta   2820

agagaacaag tgaatgacct ctttagtcgg aaatttggtg aagctattgg tatgggtttt   2880

cctgtgaaag ttccctacag gaaaatcaca attaaccctg gctgtgtggt ggttgatggc   2940

atgcccccgg gggtgtcctt caaagccccc agctacctgg aaatcagctc catgagaagg   3000

atcttagact ctgccgagtt tatcaaattc acggtcatta gaccatttcc aggacttgtg   3060

attaataacc agctggttga tcagagtgag tcagaaggcc ccgtgataca agaatcagct   3120

gaaccaagcc agttggaagt tccagccaca gaagaaataa aagagactga tggaagctct   3180

cagatcaagc aagaaccaga ccccacgtgg tagacctctt ccctcctagg caaaaccatc   3240

tggatcacct aacagtcaga ggtcagtatc tcagcgtgtg aattatagag gaaatacaga   3300

gagaacctct tccactttta cttttcgtcc aaataaaatg catggtgtac cagaagttga   3360

agatcgggtt gaggattggg gctagctcga tgacactaag gccccaacat cgcgggacct   3420

gctgtggcgc ggattcttag gaacgctgtt ctagccggcc ccctctccag gggtcgccgt   3480

ggccggcatt atttcctagt tcttcttgta accctgaggt gccagcgcgg ggagtgagga   3540

ggggtcaggg ggctaaggat gcaacctctg acgttctgcg ccttcctagg agagtcttac   3600

atgtgttgag atttcacaag caatgcgagt tgtaaaatac cagctctaca agaagctagg   3660

ctctgtgacg gcatagtttt cagtagcttt atcacaatat tcacaatgga gaattatatg   3720

acatggtagc agaaataggc ccttttatgt gttgcttcta ttttacctca aattgtagat   3780

atagggtaat caataaaatc catccatgcc tttcacacac taagt                   3825


<210>  4333
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  4333

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys 
                565                 570                 575


Asn Leu Asn 



<210>  4334
<211>  4267
<212>  DNA
<213>  Homo sapiens

<400>  4334
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1980

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct tagatttgtt   2040

gacagcggtt tcctggagtg ctgtcttgag aacgattctg aggaggctca gcaagaaaga   2100

gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa ctcaagctct tggactcacc   2160

gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc cggagttctt gtatgtggaa   2220

ggcttgccag aggggattcc cttccgaagc cctacctggt ttggaattcc acgacttgaa   2280

aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta aaaaacctga actagttatt   2340

tcctacttgc ctcctgggat ggctagtaaa ataaacacta aagctttgca gtcccccaaa   2400

agaccacgaa gtcctgggag taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc   2460

cctaataaca acaatcctca aacctcagct gttcgaaccc cgacccagac taacggttct   2520

aacgttccct tcaagccacg agggagagag ttttcctttg aggcctggaa tgccaaaatc   2580

acggacctaa aacagaaagt tgaaaatctc ttcaatgaga aatgtgggga agctcttggc   2640

cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt ctttcccgga agacttttat   2700

gtggaaggct tacctgaggg tgtgccattc cgaagaccat cgacttttgg cattccgagg   2760

ctggagaaga tactcagaaa caaagccaaa attaagttca tcattaaaaa gcccgaaatg   2820

tttgagacgg cgattaagga gagcacctcc tctaagagcc ctcccagaaa aataaattca   2880

tcacccaatg ttaatactac tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca   2940

attccagatg atgataatga aagactctcg aaagttgaaa aagctagaca gctaagagaa   3000

caagtgaatg acctctttag tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg   3060

aaagttccct acaggaaaat cacaattaac cctggctgtg tggtggttga tggcatgccc   3120

ccgggggtgt ccttcaaagc ccccagctac ctggaaatca gctccatgag aaggatctta   3180

gactctgccg agtttatcaa attcacggtc attagaccat ttccaggact tgtgattaat   3240

aaccagctgg ttgatcagag tgagtcagaa ggccccgtga tacaagaatc agctgaacca   3300

agccagttgg aagttccagc cacagaagaa ataaaagaga ctgatggaag ctctcagatc   3360

aagcaagaac cagaccccac gtggtagacc tcttccctcc taggagcctt gagttacggt   3420

gtttattttc caatcaagtg aagatatctc ctacttctcc tactggaaca tctcagcttc   3480

tgcagtgaag aaaaattcct gtgatagttc agttctttag tttttctatt tgaaaaaaaa   3540

aaatcattta aatgatcctt tgttcacggc tctccttaat gactgagtga acagttccta   3600

tctgtatatt tgactaaacc ttttcctaag ctatctctca tggttcctat gtttttttat   3660

cataattaaa agcaaaacca tctggatcac ctaacagtca gaggtcagta tctcagcgtg   3720

tgaattatag aggaaataca gagagaacct cttccacttt tacttttcgt ccaaataaaa   3780

tgcatggtgt accagaagtt gaagatcggg ttgaggattg gggctagctc gatgacacta   3840

aggccccaac atcgcgggac ctgctgtggc gcggattctt aggaacgctg ttctagccgg   3900

ccccctctcc aggggtcgcc gtggccggca ttatttccta gttcttcttg taaccctgag   3960

gtgccagcgc ggggagtgag gaggggtcag ggggctaagg atgcaacctc tgacgttctg   4020

cgccttccta ggagagtctt acatgtgttg agatttcaca agcaatgcga gttgtaaaat   4080

accagctcta caagaagcta ggctctgtga cggcatagtt ttcagtagct ttatcacaat   4140

attcacaatg gagaattata tgacatggta gcagaaatag gcccttttat gtgttgcttc   4200

tattttacct caaattgtag atatagggta atcaataaaa tccatccatg cctttcacac   4260

actaagt                                                             4267


<210>  4335
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  4335

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  4336
<211>  4965
<212>  DNA
<213>  Homo sapiens

<400>  4336
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1860

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1920

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1980

aatcaaaccc ggagttcttg aaaggatcgt ccgcgggagt aataaaatca agttcgttgt   2040

taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta aaataaacac   2100

taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa aggttcctga   2160

aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag ctgttcgaac   2220

cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag agttttcctt   2280

tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc tcttcaatga   2340

gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg cgttatttga   2400

gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat tccgaagacc   2460

atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca aaattaagtt   2520

catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct cctctaagag   2580

ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag gtgttgaaga   2640

ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct cgaaagttga   2700

aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat ttggtgaagc   2760

tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta accctggctg   2820

tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct acctggaaat   2880

cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg tcattagacc   2940

atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag aaggccccgt   3000

gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag aaataaaaga   3060

gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga cctcttccct   3120

cctagggtaa atcagcttct gtgtcaggga tgctgtgtgg tgtccatctg aaccccctgc   3180

atacgcgtag ctaatgtgat ctccccactt tcacataaga tggtggccct gccttcaggg   3240

aatgtgggag ccaggtggga gccttcccgg atatttaagc tagaagattc tacagggaga   3300

ttctccttgg atcaatatat gtctctcagt caaagatgta aaagcacttt tgccttaaaa   3360

agaatgttct gtttctaaat agagtcaacg ttgtcctcct cattggaatt cactatgagt   3420

cagaatcatt agactgactt ttttttttcc atagtaatag tattttgcag agtctcacag   3480

agctgcagat cttttgttca tcttgcagag ttaacaagtc tgatcctgtt agtccagatt   3540

tcttaaattt ggccaagtta taataggagc agtagcttga gacccgaagt caggaaactt   3600

tgacaatgga tttttttttt taatccagag acttgtactg gaatttgcct taccctgtca   3660

gctcatggac ttaaggtttc atcccgcttt atgagtgctt ctgaatccaa gtcattgtta   3720

cctgaatttg caaattaagt tgtgatattc gtgactgtta aattcctgta attagattaa   3780

cctctttgct tgcttgtttg ttttctctcc tattttagct taaagtatca gtggttgaga   3840

agagcttttc ggacctgtta ctaccccaag ctgtgtaata tacttgtata acagaaatac   3900

cttctataca aacctttttt tctactttta gatagaaatg tctacttttt cagcagttct   3960

gtgaattaaa gagcagagtg actgtgggtc tggaatggct ggtgtacttg ggaatgtact   4020

atcaggattt tacagcaatg ctgggaaatg acagggaaaa tgacaggaat gaatctcacc   4080

agatttttta tgtactcagc agagccttga gttacggtgt ttattttcca atcaagtgaa   4140

gatatctcct acttctccta ctggaacatc tcagcttctg cagtgaagaa aaattcctgt   4200

gatagttcag ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa tgatcctttg   4260

ttcacggctc tccttaatga ctgagtgaac agttcctatc tgtatatttg actaaacctt   4320

ttcctaagct atctctcatg gttcctatgt ttttttatca taattaaaag caaaaccatc   4380

tggatcacct aacagtcaga ggtcagtatc tcagcgtgtg aattatagag gaaatacaga   4440

gagaacctct tccactttta cttttcgtcc aaataaaatg catggtgtac cagaagttga   4500

agatcgggtt gaggattggg gctagctcga tgacactaag gccccaacat cgcgggacct   4560

gctgtggcgc ggattcttag gaacgctgtt ctagccggcc ccctctccag gggtcgccgt   4620

ggccggcatt atttcctagt tcttcttgta accctgaggt gccagcgcgg ggagtgagga   4680

ggggtcaggg ggctaaggat gcaacctctg acgttctgcg ccttcctagg agagtcttac   4740

atgtgttgag atttcacaag caatgcgagt tgtaaaatac cagctctaca agaagctagg   4800

ctctgtgacg gcatagtttt cagtagcttt atcacaatat tcacaatgga gaattatatg   4860

acatggtagc agaaataggc ccttttatgt gttgcttcta ttttacctca aattgtagat   4920

atagggtaat caataaaatc catccatgcc tttcacacac taagt                   4965


<210>  4337
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  4337

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg 
            420                 425                 430


Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe 
        435                 440                 445


Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val 
    450                 455                 460


Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile 
465                 470                 475                 480


Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
                485                 490


<210>  4338
<211>  4069
<212>  DNA
<213>  Homo sapiens

<400>  4338
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gtcaaagaag attggaatgt cagaattacc aagctacgga   1920

agcaagtgga agagattttt aatttgaaat ttgctcaagc tcttggactc accgaggcag   1980

taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgaaagga tcgtccgcgg   2040

gagtaataaa atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc   2100

tgggatggct agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc   2160

tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa   2220

tcctcaaacc tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa   2280

gccacgaggg agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca   2340

gaaagttgaa aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt   2400

gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc   2460

tgagggtgtg ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact   2520

cagaaacaaa gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat   2580

taaggagagc acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa   2640

tactactgca tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga   2700

taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct   2760

ctttagtcgg aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag   2820

gaaaatcaca attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt   2880

caaagccccc agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt   2940

tatcaaattc acggtcatta gaccatttcc aggacttgtg attaataacc agctggttga   3000

tcagagtgag tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt   3060

tccagccaca gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga   3120

ccccacgtgg tagacctctt ccctcctagg cttaaagtat cagtggttga gaagagcttt   3180

tcggacctgt tactacccca agctgtagcc ttgagttacg gtgtttattt tccaatcaag   3240

tgaagatatc tcctacttct cctactggaa catctcagct tctgcagtga agaaaaattc   3300

ctgtgatagt tcagttcttt agtttttcta tttgaaaaaa aaaaatcatt taaatgatcc   3360

tttgttcacg gctctcctta atgactgagt gaacagttcc tatctgtata tttgactaaa   3420

ccttttccta agctatctct catggttcct atgttttttt atcataatta aaagcaaaac   3480

catctggatc acctaacagt cagaggtcag tatctcagcg tgtgaattat agaggaaata   3540

cagagagaac ctcttccact tttacttttc gtccaaataa aatgcatggt gtaccagaag   3600

ttgaagatcg ggttgaggat tggggctagc tcgatgacac taaggcccca acatcgcggg   3660

acctgctgtg gcgcggattc ttaggaacgc tgttctagcc ggccccctct ccaggggtcg   3720

ccgtggccgg cattatttcc tagttcttct tgtaaccctg aggtgccagc gcggggagtg   3780

aggaggggtc agggggctaa ggatgcaacc tctgacgttc tgcgccttcc taggagagtc   3840

ttacatgtgt tgagatttca caagcaatgc gagttgtaaa ataccagctc tacaagaagc   3900

taggctctgt gacggcatag ttttcagtag ctttatcaca atattcacaa tggagaatta   3960

tatgacatgg tagcagaaat aggccctttt atgtgttgct tctattttac ctcaaattgt   4020

agatataggg taatcaataa aatccatcca tgcctttcac acactaagt               4069


<210>  4339
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  4339

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
                485                 490                 495


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
            500                 505                 510


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
        515                 520                 525


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser 
    530                 535                 540


Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
545                 550                 555


<210>  4340
<211>  4175
<212>  DNA
<213>  Homo sapiens

<400>  4340
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   1980

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2040

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2100

atcaaacccg gagttcttgt atgtggaagg cttgccagag gggattccct tccgaagccc   2160

tacctggttt ggaattccac gacttgaaag gatcgtccgc gggagtaata aaatcaagtt   2220

cgttgttaaa aaacctgaac tagttatttc ctacttgcct cctgggatgg ctagtaaaat   2280

aaacactaaa gctttgcagt cccccaaaag accacgaagt cctgggagta attcaaaggt   2340

tcctgaaatt gaggtcaccg tggaaggccc taataacaac aatcctcaaa cctcagctgt   2400

tcgaaccccg acccagacta acggttctaa cgttcccttc aagccacgag ggagagagtt   2460

ttcctttgag gcctggaatg ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt   2520

caatgagaaa tgtggggaag ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt   2580

atttgagtct ttcccggaag acttttatgt ggaaggctta cctgagggtg tgccattccg   2640

aagaccatcg acttttggca ttccgaggct ggagaagata ctcagaaaca aagccaaaat   2700

taagttcatc attaaaaagc ccgaaatgtt tgagacggcg attaaggaga gcacctcctc   2760

taagagccct cccagaaaaa taaattcatc acccaatgtt aatactactg catcaggtgt   2820

tgaagacctt aacatcattc aggtgacaat tccagatgat gataatgaaa gactctcgaa   2880

agttgaaaaa gctagacagc taagagaaca agtgaatgac ctctttagtc ggaaatttgg   2940

tgaagctatt ggtatgggtt ttcctgtgaa agttccctac aggaaaatca caattaaccc   3000

tggctgtgtg gtggttgatg gcatgccccc gggggtgtcc ttcaaagccc ccagctacct   3060

ggaaatcagc tccatgagaa ggatcttaga ctctgccgag tttatcaaat tcacggtcat   3120

tagaccattt ccaggacttg tgattaataa ccagctggtt gatcagagtg agtcagaagg   3180

ccccgtgata caagaatcag ctgaaccaag ccagttggaa gttccagcca cagaagaaat   3240

aaaagagact gatggaagct ctcagatcaa gcaagaacca gaccccacgt ggtagacctc   3300

ttccctccta ggagccttga gttacggtgt ttattttcca atcaagtgaa gatatctcct   3360

acttctccta ctggaacatc tcagcttctg cagtgaagaa aaattcctgt gatagttcag   3420

ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa tgatcctttg ttcacggctc   3480

tccttaatga ctgagtgaac agttcctatc tgtatatttg actaaacctt ttcctaagct   3540

atctctcatg gttcctatgt ttttttatca taattaaaag caaaaccatc tggatcacct   3600

aacagtcaga ggtcagtatc tcagcgtgtg aattatagag gaaatacaga gagaacctct   3660

tccactttta cttttcgtcc aaataaaatg catggtgtac cagaagttga agatcgggtt   3720

gaggattggg gctagctcga tgacactaag gccccaacat cgcgggacct gctgtggcgc   3780

ggattcttag gaacgctgtt ctagccggcc ccctctccag gggtcgccgt ggccggcatt   3840

atttcctagt tcttcttgta accctgaggt gccagcgcgg ggagtgagga ggggtcaggg   3900

ggctaaggat gcaacctctg acgttctgcg ccttcctagg agagtcttac atgtgttgag   3960

atttcacaag caatgcgagt tgtaaaatac cagctctaca agaagctagg ctctgtgacg   4020

gcatagtttt cagtagcttt atcacaatat tcacaatgga gaattatatg acatggtagc   4080

agaaataggc ccttttatgt gttgcttcta ttttacctca aattgtagat atagggtaat   4140

caataaaatc catccatgcc tttcacacac taagt                              4175


<210>  4341
<211>  957
<212>  PRT
<213>  Homo sapiens

<400>  4341

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
                565                 570                 575


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
            580                 585                 590


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
        595                 600                 605


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
    610                 615                 620


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
625                 630                 635                 640


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
                645                 650                 655


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
            660                 665                 670


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
        675                 680                 685


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
    690                 695                 700


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
705                 710                 715                 720


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
                725                 730                 735


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
            740                 745                 750


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
        755                 760                 765


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
    770                 775                 780


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
785                 790                 795                 800


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
                805                 810                 815


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
            820                 825                 830


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
        835                 840                 845


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
    850                 855                 860


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
865                 870                 875                 880


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
                885                 890                 895


Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu 
            900                 905                 910


Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu 
        915                 920                 925


Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp 
    930                 935                 940


Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950                 955


<210>  4342
<211>  5139
<212>  DNA
<213>  Homo sapiens

<400>  4342
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagctca   2040

agctcttgga ctcaccgagg cagtaaaagt accatatcct gtgtttgaat caaacccgga   2100

gttcttgtat gtggaaggct tgccagaggg gattcccttc cgaagcccta cctggtttgg   2160

aattccacga cttgaaagga tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa   2220

acctgaacta gttatttcct acttgcctcc tgggatggct agtaaaataa acactaaagc   2280

tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga   2340

ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc tcagctgttc gaaccccgac   2400

ccagactaac ggttctaacg ttcccttcaa gccacgaggg agagagtttt cctttgaggc   2460

ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa aatctcttca atgagaaatg   2520

tggggaagct cttggcctta aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt   2580

cccggaagac ttttatgtgg aaggcttacc tgagggtgtg ccattccgaa gaccatcgac   2640

ttttggcatt ccgaggctgg agaagatact cagaaacaaa gccaaaatta agttcatcat   2700

taaaaagccc gaaatgtttg agacggcgat taaggagagc acctcctcta agagccctcc   2760

cagaaaaata aattcatcac ccaatgttaa tactactgca tcaggtgttg aagaccttaa   2820

catcattcag gtgacaattc cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc   2880

tagacagcta agagaacaag tgaatgacct ctttagtcgg aaatttggtg aagctattgg   2940

tatgggtttt cctgtgaaag ttccctacag gaaaatcaca attaaccctg gctgtgtggt   3000

ggttgatggc atgcccccgg gggtgtcctt caaagccccc agctacctgg aaatcagctc   3060

catgagaagg atcttagact ctgccgagtt tatcaaattc acggtcatta gaccatttcc   3120

aggacttgtg attaataacc agctggttga tcagagtgag tcagaaggcc ccgtgataca   3180

agaatcagct gaaccaagcc agttggaagt tccagccaca gaagaaataa aagagactga   3240

tggaagctct cagatcaagc aagaaccaga ccccacgtgg tagacctctt ccctcctagg   3300

gtaaatcagc ttctgtgtca gggatgctgt gtggtgtcca tctgaacccc ctgcatacgc   3360

gtagctaatg tgatctcccc actttcacat aagatggtgg ccctgccttc agggaatgtg   3420

ggagccaggt gggagccttc ccggatattt aagctagaag attctacagg gagattctcc   3480

ttggatcaat atatgtctct cagtcaaaga tgtaaaagca cttttgcctt aaaaagaatg   3540

ttctgtttct aaatagagtc aacgttgtcc tcctcattgg aattcactat gagtcagaat   3600

cattagactg actttttttt ttccatagta atagtatttt gcagagtctc acagagctgc   3660

agatcttttg ttcatcttgc agagttaaca agtctgatcc tgttagtcca gatttcttaa   3720

atttggccaa gttataatag gagcagtagc ttgagacccg aagtcaggaa actttgacaa   3780

tggatttttt tttttaatcc agagacttgt actggaattt gccttaccct gtcagctcat   3840

ggacttaagg tttcatcccg ctttatgagt gcttctgaat ccaagtcatt gttacctgaa   3900

tttgcaaatt aagttgtgat attcgtgact gttaaattcc tgtaattaga ttaacctctt   3960

tgcttgcttg tttgttttct ctcctatttt agcttaaagt atcagtggtt gagaagagct   4020

tttcggacct gttactaccc caagctgtgt aatatacttg tataacagaa ataccttcta   4080

tacaaacctt tttttctact tttagataga aatgtctact ttttcagcag ttctgtgaat   4140

taaagagcag agtgactgtg ggtctggaat ggctggtgta cttgggaatg tactatcagg   4200

attttacagc aatgctggga aatgacaggg aaaatgacag gaatgaatct caccagattt   4260

tttatgtact cagcagagcc ttgagttacg gtgtttattt tccaatcaag tgaagatatc   4320

tcctacttct cctactggaa catctcagct tctgcagtga agaaaaattc ctgtgatagt   4380

tcagttcttt agtttttcta tttgaaaaaa aaaaatcatt taaatgatcc tttgttcacg   4440

gctctcctta atgactgagt gaacagttcc tatctgtata tttgactaaa ccttttccta   4500

agctatctct catggttcct atgttttttt atcataatta aaagcaaaac catctggatc   4560

acctaacagt cagaggtcag tatctcagcg tgtgaattat agaggaaata cagagagaac   4620

ctcttccact tttacttttc gtccaaataa aatgcatggt gtaccagaag ttgaagatcg   4680

ggttgaggat tggggctagc tcgatgacac taaggcccca acatcgcggg acctgctgtg   4740

gcgcggattc ttaggaacgc tgttctagcc ggccccctct ccaggggtcg ccgtggccgg   4800

cattatttcc tagttcttct tgtaaccctg aggtgccagc gcggggagtg aggaggggtc   4860

agggggctaa ggatgcaacc tctgacgttc tgcgccttcc taggagagtc ttacatgtgt   4920

tgagatttca caagcaatgc gagttgtaaa ataccagctc tacaagaagc taggctctgt   4980

gacggcatag ttttcagtag ctttatcaca atattcacaa tggagaatta tatgacatgg   5040

tagcagaaat aggccctttt atgtgttgct tctattttac ctcaaattgt agatataggg   5100

taatcaataa aatccatcca tgcctttcac acactaagt                          5139


<210>  4343
<211>  953
<212>  PRT
<213>  Homo sapiens

<400>  4343

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu 
    530                 535                 540


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
545                 550                 555                 560


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
                565                 570                 575


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
            580                 585                 590


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
        595                 600                 605


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
    610                 615                 620


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
625                 630                 635                 640


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
                645                 650                 655


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
            660                 665                 670


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
        675                 680                 685


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
    690                 695                 700


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
705                 710                 715                 720


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
                725                 730                 735


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
            740                 745                 750


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
        755                 760                 765


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
    770                 775                 780


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
785                 790                 795                 800


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
                805                 810                 815


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
            820                 825                 830


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
        835                 840                 845


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
    850                 855                 860


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
865                 870                 875                 880


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
                885                 890                 895


Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser 
            900                 905                 910


Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu 
        915                 920                 925


Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln 
    930                 935                 940


Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  4344
<211>  4418
<212>  DNA
<213>  Homo sapiens

<400>  4344
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040

taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2100

ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2160

ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2220

ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2280

ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2340

atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2400

agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2460

agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2520

tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2580

ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2640

tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2700

ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2760

atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2820

ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2880

tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   2940

ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   3000

tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3060

ttatcaaatt cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg   3120

atcagagtga gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag   3180

ttccagccac agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag   3240

accccacgtg gtagacctct tccctcctag gcttaaagta tcagtggttg agaagagctt   3300

ttcggacctg ttactacccc aagctgtgta atatacttgt ataacagaaa taccttctat   3360

acaaaccttt ttttctactt ttagatagaa atgtctactt tttcagcagt tctgtgaatt   3420

aaagagcaga gtgactgtgg gtctggaatg gctggtgtac ttgggaatgt actatcagga   3480

ttttacagca atgctgggaa atgacaggga aaatgacagg aatgaatctc accagatttt   3540

ttatgtactc agcagagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct   3600

cctacttctc ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt   3660

cagttcttta gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg   3720

ctctccttaa tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa   3780

gctatctctc atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca   3840

cctaacagtc agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc   3900

tcttccactt ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg   3960

gttgaggatt ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg   4020

cgcggattct taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc   4080

attatttcct agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca   4140

gggggctaag gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt   4200

gagatttcac aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg   4260

acggcatagt tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt   4320

agcagaaata ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt   4380

aatcaataaa atccatccat gcctttcaca cactaagt                           4418


<210>  4345
<211>  889
<212>  PRT
<213>  Homo sapiens

<400>  4345

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
    450                 455                 460


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
465                 470                 475                 480


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
                485                 490                 495


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
            500                 505                 510


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
        515                 520                 525


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
    530                 535                 540


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
545                 550                 555                 560


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
                565                 570                 575


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
            580                 585                 590


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
        595                 600                 605


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
    610                 615                 620


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
625                 630                 635                 640


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
                645                 650                 655


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
            660                 665                 670


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
        675                 680                 685


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
    690                 695                 700


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
705                 710                 715                 720


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
                725                 730                 735


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
            740                 745                 750


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
        755                 760                 765


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
    770                 775                 780


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
785                 790                 795                 800


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
                805                 810                 815


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
            820                 825                 830


Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser 
        835                 840                 845


Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu 
    850                 855                 860


Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln 
865                 870                 875                 880


Ile Lys Gln Glu Pro Asp Pro Thr Trp 
                885


<210>  4346
<211>  3999
<212>  DNA
<213>  Homo sapiens

<400>  4346
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agctcaagct cttggactca ccgaggcagt aaaagtacca tatcctgtgt   1920

ttgaatcaaa cccggagttc ttgtatgtgg aaggcttgcc agaggggatt cccttccgaa   1980

gccctacctg gtttggaatt ccacgacttg aaaggatcgt ccgcgggagt aataaaatca   2040

agttcgttgt taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta   2100

aaataaacac taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa   2160

aggttcctga aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag   2220

ctgttcgaac cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag   2280

agttttcctt tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc   2340

tcttcaatga gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg   2400

cgttatttga gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat   2460

tccgaagacc atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca   2520

aaattaagtt catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct   2580

cctctaagag ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag   2640

gtgttgaaga ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct   2700

cgaaagttga aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat   2760

ttggtgaagc tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta   2820

accctggctg tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct   2880

acctggaaat cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg   2940

tcattagacc atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag   3000

aaggccccgt gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag   3060

aaataaaaga gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga   3120

cctcttccct cctaggagcc ttgagttacg gtgtttattt tccaatcaag tgaagatatc   3180

tcctacttct cctactggaa catctcagct tctgcagtga agaaaaattc ctgtgatagt   3240

tcagttcttt agtttttcta tttgaaaaaa aaaaatcatt taaatgatcc tttgttcacg   3300

gctctcctta atgactgagt gaacagttcc tatctgtata tttgactaaa ccttttccta   3360

agctatctct catggttcct atgttttttt atcataatta aaagcaaaac catctggatc   3420

acctaacagt cagaggtcag tatctcagcg tgtgaattat agaggaaata cagagagaac   3480

ctcttccact tttacttttc gtccaaataa aatgcatggt gtaccagaag ttgaagatcg   3540

ggttgaggat tggggctagc tcgatgacac taaggcccca acatcgcggg acctgctgtg   3600

gcgcggattc ttaggaacgc tgttctagcc ggccccctct ccaggggtcg ccgtggccgg   3660

cattatttcc tagttcttct tgtaaccctg aggtgccagc gcggggagtg aggaggggtc   3720

agggggctaa ggatgcaacc tctgacgttc tgcgccttcc taggagagtc ttacatgtgt   3780

tgagatttca caagcaatgc gagttgtaaa ataccagctc tacaagaagc taggctctgt   3840

gacggcatag ttttcagtag ctttatcaca atattcacaa tggagaatta tatgacatgg   3900

tagcagaaat aggccctttt atgtgttgct tctattttac ctcaaattgt agatataggg   3960

taatcaataa aatccatcca tgcctttcac acactaagt                          3999


<210>  4347
<211>  844
<212>  PRT
<213>  Homo sapiens

<400>  4347

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala 
            420                 425                 430


Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser 
        435                 440                 445


Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
    450                 455                 460


Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg 
465                 470                 475                 480


Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile 
                485                 490                 495


Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu 
            500                 505                 510


Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro 
        515                 520                 525


Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr 
    530                 535                 540


Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe 
545                 550                 555                 560


Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile 
                565                 570                 575


Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly 
            580                 585                 590


Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe 
        595                 600                 605


Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val 
    610                 615                 620


Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile 
625                 630                 635                 640


Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met 
                645                 650                 655


Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg 
            660                 665                 670


Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu 
        675                 680                 685


Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg 
    690                 695                 700


Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp 
705                 710                 715                 720


Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val 
                725                 730                 735


Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val 
            740                 745                 750


Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu 
        755                 760                 765


Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe 
    770                 775                 780


Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val 
785                 790                 795                 800


Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro 
                805                 810                 815


Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly 
            820                 825                 830


Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
        835                 840


<210>  4348
<211>  4062
<212>  DNA
<213>  Homo sapiens

<400>  4348
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   1980

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   2040

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2100

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2160

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2220

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2280

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2340

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2400

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2460

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2520

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2580

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2640

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2700

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2760

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2820

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2880

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   2940

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   3000

cggtcattag accatttcca ggacttgtga ttaataacca gctggttgat cagagtgagt   3060

cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt ccagccacag   3120

aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac cccacgtggt   3180

agacctcttc cctcctagga gccttgagtt acggtgttta ttttccaatc aagtgaagat   3240

atctcctact tctcctactg gaacatctca gcttctgcag tgaagaaaaa ttcctgtgat   3300

agttcagttc tttagttttt ctatttgaaa aaaaaaaatc atttaaatga tcctttgttc   3360

acggctctcc ttaatgactg agtgaacagt tcctatctgt atatttgact aaaccttttc   3420

ctaagctatc tctcatggtt cctatgtttt tttatcataa ttaaaagcaa aaccatctgg   3480

atcacctaac agtcagaggt cagtatctca gcgtgtgaat tatagaggaa atacagagag   3540

aacctcttcc acttttactt ttcgtccaaa taaaatgcat ggtgtaccag aagttgaaga   3600

tcgggttgag gattggggct agctcgatga cactaaggcc ccaacatcgc gggacctgct   3660

gtggcgcgga ttcttaggaa cgctgttcta gccggccccc tctccagggg tcgccgtggc   3720

cggcattatt tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga gtgaggaggg   3780

gtcagggggc taaggatgca acctctgacg ttctgcgcct tcctaggaga gtcttacatg   3840

tgttgagatt tcacaagcaa tgcgagttgt aaaataccag ctctacaaga agctaggctc   3900

tgtgacggca tagttttcag tagctttatc acaatattca caatggagaa ttatatgaca   3960

tggtagcaga aataggccct tttatgtgtt gcttctattt tacctcaaat tgtagatata   4020

gggtaatcaa taaaatccat ccatgccttt cacacactaa gt                      4062


<210>  4349
<211>  865
<212>  PRT
<213>  Homo sapiens

<400>  4349

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
    450                 455                 460


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
465                 470                 475                 480


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
                485                 490                 495


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
            500                 505                 510


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
        515                 520                 525


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
    530                 535                 540


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
545                 550                 555                 560


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
                565                 570                 575


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
            580                 585                 590


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
        595                 600                 605


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
    610                 615                 620


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
625                 630                 635                 640


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
                645                 650                 655


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
            660                 665                 670


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
        675                 680                 685


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
    690                 695                 700


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
705                 710                 715                 720


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
                725                 730                 735


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
            740                 745                 750


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
        755                 760                 765


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
    770                 775                 780


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
785                 790                 795                 800


Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile 
                805                 810                 815


Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln 
            820                 825                 830


Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile 
        835                 840                 845


Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr 
    850                 855                 860


Trp 
865


<210>  4350
<211>  5231
<212>  DNA
<213>  Homo sapiens

<400>  4350
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   2040

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   2100

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2160

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2220

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2280

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2340

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2400

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2460

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2520

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2580

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2640

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2700

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2760

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2820

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2880

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2940

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   3000

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   3060

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3120

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3180

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3240

ttcacggtca ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt   3300

gagtcagaag gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc   3360

acagaaggta aaaggacctc ttccctccta gggtaaatca gcttctgtgt cagggatgct   3420

gtgtggtgtc catctgaacc ccctgcatac gcgtagctaa tgtgatctcc ccactttcac   3480

ataagatggt ggccctgcct tcagggaatg tgggagccag gtgggagcct tcccggatat   3540

ttaagctaga agattctaca gggagattct ccttggatca atatatgtct ctcagtcaaa   3600

gatgtaaaag cacttttgcc ttaaaaagaa tgttctgttt ctaaatagag tcaacgttgt   3660

cctcctcatt ggaattcact atgagtcaga atcattagac tgactttttt ttttccatag   3720

taatagtatt ttgcagagtc tcacagagct gcagatcttt tgttcatctt gcagagttaa   3780

caagtctgat cctgttagtc cagatttctt aaatttggcc aagttataat aggagcagta   3840

gcttgagacc cgaagtcagg aaactttgac aatggatttt tttttttaat ccagagactt   3900

gtactggaat ttgccttacc ctgtcagctc atggacttaa ggtttcatcc cgctttatga   3960

gtgcttctga atccaagtca ttgttacctg aatttgcaaa ttaagttgtg atattcgtga   4020

ctgttaaatt cctgtaatta gattaacctc tttgcttgct tgtttgtttt ctctcctatt   4080

ttagcttaaa gtatcagtgg ttgagaagag cttttcggac ctgttactac cccaagctgt   4140

gtaatatact tgtataacag aaataccttc tatacaaacc tttttttcta cttttagata   4200

gaaatgtcta ctttttcagc agttctgtga attaaagagc agagtgactg tgggtctgga   4260

atggctggtg tacttgggaa tgtactatca ggattttaca gcaatgctgg gaaatgacag   4320

ggaaaatgac aggaatgaat ctcaccagat tttttatgta ctcagcagag ccttgagtta   4380

cggtgtttat tttccaatca agtgaagata tctcctactt ctcctactgg aacatctcag   4440

cttctgcagt gaagaaaaat tcctgtgata gttcagttct ttagtttttc tatttgaaaa   4500

aaaaaaatca tttaaatgat cctttgttca cggctctcct taatgactga gtgaacagtt   4560

cctatctgta tatttgacta aaccttttcc taagctatct ctcatggttc ctatgttttt   4620

ttatcataat taaaagcaaa accatctgga tcacctaaca gtcagaggtc agtatctcag   4680

cgtgtgaatt atagaggaaa tacagagaga acctcttcca cttttacttt tcgtccaaat   4740

aaaatgcatg gtgtaccaga agttgaagat cgggttgagg attggggcta gctcgatgac   4800

actaaggccc caacatcgcg ggacctgctg tggcgcggat tcttaggaac gctgttctag   4860

ccggccccct ctccaggggt cgccgtggcc ggcattattt cctagttctt cttgtaaccc   4920

tgaggtgcca gcgcggggag tgaggagggg tcagggggct aaggatgcaa cctctgacgt   4980

tctgcgcctt cctaggagag tcttacatgt gttgagattt cacaagcaat gcgagttgta   5040

aaataccagc tctacaagaa gctaggctct gtgacggcat agttttcagt agctttatca   5100

caatattcac aatggagaat tatatgacat ggtagcagaa ataggccctt ttatgtgttg   5160

cttctatttt acctcaaatt gtagatatag ggtaatcaat aaaatccatc catgcctttc   5220

acacactaag t                                                        5231


<210>  4351
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  4351

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
465                 470                 475                 480


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
                485                 490                 495


<210>  4352
<211>  4694
<212>  DNA
<213>  Homo sapiens

<400>  4352
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2100

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2160

tttgaaattt gcttagattt gttgacagcg gtttcctgga gtgctgtctt gagaacgatt   2220

ctgaggaggc tcagcaagaa agagtgtttc agttgattgg gtgtgtctgt catggagaag   2280

gaactcaagc tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa   2340

acccggagtt cttgtatgtg gaaggcttgc cagaggggat tcccttccga agccctacct   2400

ggtttggaat tccacgactt gaaaggatcg tccgcgggag taataaaatc aagttcgttg   2460

ttaaaaaacc tgaactagtt atttcctact tgcctcctgg gatggctagt aaaataaaca   2520

ctaaagcttt gcagtccccc aaaagaccac gaagtcctgg gagtaattca aaggttcctg   2580

aaattgaggt caccgtggaa ggccctaata acaacaatcc tcaaacctca gctgttcgaa   2640

ccccgaccca gactaacggt tctaacgttc ccttcaagcc acgagggaga gagttttcct   2700

ttgaggcctg gaatgccaaa atcacggacc taaaacagaa agttgaaaat ctcttcaatg   2760

agaaatgtgg ggaagctctt ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg   2820

agtctttccc ggaagacttt tatgtggaag gcttacctga gggtgtgcca ttccgaagac   2880

catcgacttt tggcattccg aggctggaga agatactcag aaacaaagcc aaaattaagt   2940

tcatcattaa aaagcccgaa atgtttgaga cggcgattaa ggagagcacc tcctctaaga   3000

gccctcccag aaaaataaat tcatcaccca atgttaatac tactgcatca ggtgttgaag   3060

accttaacat cattcaggtg acaattccag atgatgataa tgaaagactc tcgaaagttg   3120

aaaaagctag acagctaaga gaacaagtga atgacctctt tagtcggaaa tttggtgaag   3180

ctattggtat gggttttcct gtgaaagttc cctacaggaa aatcacaatt aaccctggct   3240

gtgtggtggt tgatggcatg cccccggggg tgtccttcaa agcccccagc tacctggaaa   3300

tcagctccat gagaaggatc ttagactctg ccgagtttat caaattcacg gtcattagac   3360

catttccagg acttgtgatt aataaccagc tggttgatca gagtgagtca gaaggccccg   3420

tgatacaaga atcagctgaa ccaagccagt tggaagttcc agccacagaa gaaataaaag   3480

agactgatgg aagctctcag atcaagcaag aaccagaccc cacgtggtag acctcttccc   3540

tcctaggctt aaagtatcag tggttgagaa gagcttttcg gacctgttac taccccaagc   3600

tgtgtaatat acttgtataa cagaaatacc ttctatacaa accttttttt ctacttttag   3660

atagaaatgt ctactttttc agcagttctg tgaattaaag agcagagtga ctgtgggtct   3720

ggaatggctg gtgtacttgg gaatgtacta tcaggatttt acagcaatgc tgggaaatga   3780

cagggaaaat gacaggaatg aatctcacca gattttttat gtactcagca gagccttgag   3840

ttacggtgtt tattttccaa tcaagtgaag atatctccta cttctcctac tggaacatct   3900

cagcttctgc agtgaagaaa aattcctgtg atagttcagt tctttagttt ttctatttga   3960

aaaaaaaaaa tcatttaaat gatcctttgt tcacggctct ccttaatgac tgagtgaaca   4020

gttcctatct gtatatttga ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt   4080

tttttatcat aattaaaagc aaaaccatct ggatcaccta acagtcagag gtcagtatct   4140

cagcgtgtga attatagagg aaatacagag agaacctctt ccacttttac ttttcgtcca   4200

aataaaatgc atggtgtacc agaagttgaa gatcgggttg aggattgggg ctagctcgat   4260

gacactaagg ccccaacatc gcgggacctg ctgtggcgcg gattcttagg aacgctgttc   4320

tagccggccc cctctccagg ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa   4380

ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg gctaaggatg caacctctga   4440

cgttctgcgc cttcctagga gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt   4500

gtaaaatacc agctctacaa gaagctaggc tctgtgacgg catagttttc agtagcttta   4560

tcacaatatt cacaatggag aattatatga catggtagca gaaataggcc cttttatgtg   4620

ttgcttctat tttacctcaa attgtagata tagggtaatc aataaaatcc atccatgcct   4680

ttcacacact aagt                                                     4694


<210>  4353
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  4353

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala 
            580


<210>  4354
<211>  4343
<212>  DNA
<213>  Homo sapiens

<400>  4354
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agctcaagct cttggactca ccgaggcagt aaaagtacca tatcctgtgt   1980

ttgaatcaaa cccggagttc ttgtatgtgg aaggcttgcc agaggggatt cccttccgaa   2040

gccctacctg gtttggaatt ccacgacttg aaaggatcgt ccgcgggagt aataaaatca   2100

agttcgttgt taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta   2160

aaataaacac taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa   2220

aggttcctga aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag   2280

ctgttcgaac cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag   2340

agttttcctt tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc   2400

tcttcaatga gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg   2460

cgttatttga gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat   2520

tccgaagacc atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca   2580

aaattaagtt catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct   2640

cctctaagag ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag   2700

gtgttgaaga ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct   2760

cgaaagttga aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat   2820

ttggtgaagc tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta   2880

accctggctg tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct   2940

acctggaaat cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg   3000

tcattagacc atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag   3060

aaggccccgt gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag   3120

aaataaaaga gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga   3180

cctcttccct cctaggctta aagtatcagt ggttgagaag agcttttcgg acctgttact   3240

accccaagct gtgtaatata cttgtataac agaaatacct tctatacaaa cctttttttc   3300

tacttttaga tagaaatgtc tactttttca gcagttctgt gaattaaaga gcagagtgac   3360

tgtgggtctg gaatggctgg tgtacttggg aatgtactat caggatttta cagcaatgct   3420

gggaaatgac agggaaaatg acaggaatga atctcaccag attttttatg tactcagcag   3480

agccttgagt tacggtgttt attttccaat caagtgaaga tatctcctac ttctcctact   3540

ggaacatctc agcttctgca gtgaagaaaa attcctgtga tagttcagtt ctttagtttt   3600

tctatttgaa aaaaaaaaat catttaaatg atcctttgtt cacggctctc cttaatgact   3660

gagtgaacag ttcctatctg tatatttgac taaacctttt cctaagctat ctctcatggt   3720

tcctatgttt ttttatcata attaaaagca aaaccatctg gatcacctaa cagtcagagg   3780

tcagtatctc agcgtgtgaa ttatagagga aatacagaga gaacctcttc cacttttact   3840

tttcgtccaa ataaaatgca tggtgtacca gaagttgaag atcgggttga ggattggggc   3900

tagctcgatg acactaaggc cccaacatcg cgggacctgc tgtggcgcgg attcttagga   3960

acgctgttct agccggcccc ctctccaggg gtcgccgtgg ccggcattat ttcctagttc   4020

ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc   4080

aacctctgac gttctgcgcc ttcctaggag agtcttacat gtgttgagat ttcacaagca   4140

atgcgagttg taaaatacca gctctacaag aagctaggct ctgtgacggc atagttttca   4200

gtagctttat cacaatattc acaatggaga attatatgac atggtagcag aaataggccc   4260

ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat agggtaatca ataaaatcca   4320

tccatgcctt tcacacacta agt                                           4343


<210>  4355
<211>  864
<212>  PRT
<213>  Homo sapiens

<400>  4355

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro 
    450                 455                 460


Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu 
465                 470                 475                 480


Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu 
                485                 490                 495


Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro 
            500                 505                 510


Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn 
        515                 520                 525


Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn 
    530                 535                 540


Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn 
545                 550                 555                 560


Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser 
                565                 570                 575


Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp 
            580                 585                 590


Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn 
        595                 600                 605


Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro 
    610                 615                 620


Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu 
625                 630                 635                 640


Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg 
                645                 650                 655


Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys 
            660                 665                 670


Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys 
        675                 680                 685


Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala 
    690                 695                 700


Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp 
705                 710                 715                 720


Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu 
                725                 730                 735


Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met 
            740                 745                 750


Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly 
        755                 760                 765


Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro 
    770                 775                 780


Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu 
785                 790                 795                 800


Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn 
                805                 810                 815


Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu 
            820                 825                 830


Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys 
        835                 840                 845


Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
    850                 855                 860


<210>  4356
<211>  4060
<212>  DNA
<213>  Homo sapiens

<400>  4356
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1980

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   2040

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2100

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2160

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2220

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2280

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2340

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2400

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2460

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2520

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2580

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2640

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2700

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2760

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2820

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2880

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   2940

cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg atcagagtga   3000

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   3060

agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag accccacgtg   3120

gtagacctct tccctcctag gcttaaagta tcagtggttg agaagagctt ttcggacctg   3180

ttactacccc aagctgtagc cttgagttac ggtgtttatt ttccaatcaa gtgaagatat   3240

ctcctacttc tcctactgga acatctcagc ttctgcagtg aagaaaaatt cctgtgatag   3300

ttcagttctt tagtttttct atttgaaaaa aaaaaatcat ttaaatgatc ctttgttcac   3360

ggctctcctt aatgactgag tgaacagttc ctatctgtat atttgactaa accttttcct   3420

aagctatctc tcatggttcc tatgtttttt tatcataatt aaaagcaaaa ccatctggat   3480

cacctaacag tcagaggtca gtatctcagc gtgtgaatta tagaggaaat acagagagaa   3540

cctcttccac ttttactttt cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc   3600

gggttgagga ttggggctag ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt   3660

ggcgcggatt cttaggaacg ctgttctagc cggccccctc tccaggggtc gccgtggccg   3720

gcattatttc ctagttcttc ttgtaaccct gaggtgccag cgcggggagt gaggaggggt   3780

cagggggcta aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg   3840

ttgagatttc acaagcaatg cgagttgtaa aataccagct ctacaagaag ctaggctctg   3900

tgacggcata gttttcagta gctttatcac aatattcaca atggagaatt atatgacatg   3960

gtagcagaaa taggcccttt tatgtgttgc ttctatttta cctcaaattg tagatatagg   4020

gtaatcaata aaatccatcc atgcctttca cacactaagt                         4060


<210>  4357
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  4357

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
            420                 425                 430


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
        435                 440                 445


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
    450                 455                 460


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser 
465                 470                 475                 480


Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
                485                 490                 495


<210>  4358
<211>  4142
<212>  DNA
<213>  Homo sapiens

<400>  4358
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagc tcaagctctt ggactcaccg   1980

aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag   2040

gcttgccaga ggggattccc ttccgaagcc ctacctggtt tggaattcca cgacttgaaa   2100

ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt   2160

cctacttgcc tcctgggatg gctagtaaaa taaacactaa agctttgcag tcccccaaaa   2220

gaccacgaag tcctgggagt aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc   2280

ctaataacaa caatcctcaa acctcagctg ttcgaacccc gacccagact aacggttcta   2340

acgttccctt caagccacga gggagagagt tttcctttga ggcctggaat gccaaaatca   2400

cggacctaaa acagaaagtt gaaaatctct tcaatgagaa atgtggggaa gctcttggcc   2460

ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc tttcccggaa gacttttatg   2520

tggaaggctt acctgagggt gtgccattcc gaagaccatc gacttttggc attccgaggc   2580

tggagaagat actcagaaac aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt   2640

ttgagacggc gattaaggag agcacctcct ctaagagccc tcccagaaaa ataaattcat   2700

cacccaatgt taatactact gcatcaggtg ttgaagacct taacatcatt caggtgacaa   2760

ttccagatga tgataatgaa agactctcga aagttgaaaa agctagacag ctaagagaac   2820

aagtgaatga cctctttagt cggaaatttg gtgaagctat tggtatgggt tttcctgtga   2880

aagttcccta caggaaaatc acaattaacc ctggctgtgt ggtggttgat ggcatgcccc   2940

cgggggtgtc cttcaaagcc cccagctacc tggaaatcag ctccatgaga aggatcttag   3000

actctgccga gtttatcaaa ttcacggtca ttagaccatt tccaggactt gtgattaata   3060

accagctggt tgatcagagt gagtcagaag gccccgtgat acaagaatca gctgaaccaa   3120

gccagttgga agttccagcc acagaagaaa taaaagagac tgatggaagc tctcagatca   3180

agcaagaacc agaccccacg tggtagacct cttccctcct aggcttaaag tatcagtggt   3240

tgagaagagc ttttcggacc tgttactacc ccaagctgta gccttgagtt acggtgttta   3300

ttttccaatc aagtgaagat atctcctact tctcctactg gaacatctca gcttctgcag   3360

tgaagaaaaa ttcctgtgat agttcagttc tttagttttt ctatttgaaa aaaaaaaatc   3420

atttaaatga tcctttgttc acggctctcc ttaatgactg agtgaacagt tcctatctgt   3480

atatttgact aaaccttttc ctaagctatc tctcatggtt cctatgtttt tttatcataa   3540

ttaaaagcaa aaccatctgg atcacctaac agtcagaggt cagtatctca gcgtgtgaat   3600

tatagaggaa atacagagag aacctcttcc acttttactt ttcgtccaaa taaaatgcat   3660

ggtgtaccag aagttgaaga tcgggttgag gattggggct agctcgatga cactaaggcc   3720

ccaacatcgc gggacctgct gtggcgcgga ttcttaggaa cgctgttcta gccggccccc   3780

tctccagggg tcgccgtggc cggcattatt tcctagttct tcttgtaacc ctgaggtgcc   3840

agcgcgggga gtgaggaggg gtcagggggc taaggatgca acctctgacg ttctgcgcct   3900

tcctaggaga gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt aaaataccag   3960

ctctacaaga agctaggctc tgtgacggca tagttttcag tagctttatc acaatattca   4020

caatggagaa ttatatgaca tggtagcaga aataggccct tttatgtgtt gcttctattt   4080

tacctcaaat tgtagatata gggtaatcaa taaaatccat ccatgccttt cacacactaa   4140

gt                                                                  4142


<210>  4359
<211>  934
<212>  PRT
<213>  Homo sapiens

<400>  4359

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala 
        515                 520                 525


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr 
    530                 535                 540


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe 
545                 550                 555                 560


Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys 
                565                 570                 575


Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly 
            580                 585                 590


Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro 
        595                 600                 605


Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val 
    610                 615                 620


Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro 
625                 630                 635                 640


Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu 
                645                 650                 655


Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys 
            660                 665                 670


Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys 
        675                 680                 685


Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp 
    690                 695                 700


Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser 
705                 710                 715                 720


Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys 
                725                 730                 735


Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys 
            740                 745                 750


Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro 
        755                 760                 765


Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln 
    770                 775                 780


Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys 
785                 790                 795                 800


Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe 
                805                 810                 815


Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys 
            820                 825                 830


Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly 
        835                 840                 845


Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg 
    850                 855                 860


Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe 
865                 870                 875                 880


Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu 
                885                 890                 895


Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro 
            900                 905                 910


Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln 
        915                 920                 925


Glu Pro Asp Pro Thr Trp 
    930


<210>  4360
<211>  7955
<212>  DNA
<213>  Homo sapiens

<400>  4360
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   2040

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2100

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2160

tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg tttggaattc   2220

cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg   2280

aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc   2340

agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca   2400

ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga   2460

ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga   2520

atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg   2580

aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg   2640

aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg   2700

gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa   2760

agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa   2820

aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca   2880

ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac   2940

agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg   3000

gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg   3060

atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga   3120

gaaggatctt agactctgcc gagtttatca aattcacggt cattaggtaa gtgagagttt   3180

cctgcttagt cacaggagcg aatctggagc tcatgaggct gactcttcta aaatgcagcc   3240

acaggtagtc atcgaatccg gcttcctatg ctgtgcaatc aacaaatcaa aataacttgt   3300

gtcatcatta gaatgtcaga tgtgcttcta cgaactaagc tgactctttt aattctttgg   3360

caaagggttg gcaaactagg actgtttgcc aaattcaggc tgcctcctat ttttagagtc   3420

ttcctgaaac acagctacac ccgtattatc catggctgct ttcctgtcac agtgagtaag   3480

tagctgggac tgagaaggca tggcctccaa agtctaaaat atttactctc tagcactttg   3540

tagaaaaacc ttagctaggc acagtggcta acgcctgtaa tcccagcatt ttgggaggcc   3600

aaggcaggca gatcacctga ggtcaggagt tccagaccag cctggccaac atggtgaaat   3660

cccatctcta caaaaataaa acagttagct gggcatgatg gcgggtgcct gtaatcccag   3720

ctactcggga ggctgaggca ggatagtcgc ttgaacccag gaggtggagg ttgcaatgag   3780

ccaagatcat gccactgcac tccagcctgg acgacagagt gagactccat cacaagaaaa   3840

aaagaacttt gtcaacctct gtcttagggc gccttgtcac aggcttcggg tcagacggat   3900

tcaaccttgc atcagccatt tgttagccag gtcactctgt tctttgtctg taaatgagat   3960

tgatcgttgt tcccactgag agtgtcagct ccttcccgta gagcaggcat gatgattgta   4020

ctcacctctg acaccattgt gagtgccaca ttccttccca cgtccttgtc actgtaagag   4080

atgcccacct gagcaccaac cccaggttat cttccccttt gtcttccagc cccccagaaa   4140

cagctacgac tcaacctacc caatcatttc atcatcagat tgccactgtc tctagttcag   4200

gtctcttggg actggcactc agaaatctca taataaatcc tcttgaggct tctcatacac   4260

tcgtcttctt ccaatcttct ttccctcaaa atctcatatt ttggttccac ttcacccacc   4320

gtcattctcc atatcactcc caggagttag gcaaaaagcc ccttccgttc ttccgtatgt   4380

taaacttaga atcactctgt tccctgctct gcgtttctat tttttgtttt tcctccattt   4440

actagtagct taacactttc taacagtgtt cttattattg atacgtatct atctcttcca   4500

taagcttata aggtcacgga taatacttct cattgtagta cgtaaatgac gtgggctaga   4560

tatgagttga ataaacagtt atacctgtaa attcttacag agtgaaaata aattgttata   4620

ctttacaatt tgtttctctc tttagaccat ttccaggact tgtgattaat aaccgtgagt   4680

attttgtgaa gtgttttgtt tttgtttttt cctggggtct gacgtgtgtg cgtgtgagtg   4740

tgtatacatg cttaacgtat atcacgttac ttcacctatg tcagtaacca ggccaaatac   4800

ttgttttagc cctcagtaaa aacaccaggc acttcctagt tgtaaaatta ttcaagcttc   4860

ttaacttcct atcctcgatg cacttaatca taaaatggta ataatagcac cgattttggg   4920

ggagtcgttc cagtagatgg aaagcatctg gaacaggtgt cagcaagctc ctgccgacgt   4980

gtatgcataa agttttattg aaaccaccat cgtgtccatt tgtttatggc agaactgaga   5040

gatggcagca gcaagtgtgt gcctgcaaaa cctaaaatat ttactaattg gctctgcaag   5100

aaaagagttt gcatccccct aacctagaac agtgtctagc ctctagtatg tgtttagcct   5160

acagtatgtg ctcagcgaat acaatctata tttattactg cttttatgac tgttataatt   5220

actgtgcttg gatttcgtta caaagtaagt cacaatgtgc ctgcttctgt tagtatttca   5280

gcacagtgcc tggcacacat ggggctctca aatattgctg agcgagtgaa caaatgtcct   5340

ttcaattcct taacgttgat gtcattttca atagtatttt gagccaaact taattttgcg   5400

agtgtgtttt gttttcttaa ctttattatt aaaaatgtat aaaagtgagg ccaggcgtgg   5460

tggctcacgc ctgtaatccc agcagtttgg gaggctgagg caggcggatc agttgaggtt   5520

gggagttgga gaccagcccg tccaacatgg tgaaagcctg tctctactaa aaatacaaaa   5580

atcagctggg tgtggtggcg cgtgcctgta atcccagcta ctcaggaggc tgaggcagga   5640

gagttgcttg aatcctagag gtggaggttg cagtgagctg agatcgtgcc attgcactcc   5700

agcctgggca acaagagcaa aactctgtcc caataaataa ataaataaaa tgttctcttt   5760

tgttcctgtt cttgtgcggt agtgtggtat agagttttat ggtaattact gtgaattagt   5820

gattctgagg gacatatcag aactctgagg tttgtttcct tctcatcttg agggaaacag   5880

caaatgtatg ttaaaatgct tttccaaggg aacaacacat ccttacatta tttaaaccaa   5940

tctgcttcat tttcagagct ggttgatcag agtgagtcag aaggccccgt gatacaagaa   6000

tcagctgaac caagccagtt ggaagttcca gccacagaag aaataaaaga gactgatgga   6060

agctctcaga tcaagcaaga accagacccc acgtggtaga cctcttccct cctagggtaa   6120

atcagcttct gtgtcaggga tgctgtgtgg tgtccatctg aaccccctgc atacgcgtag   6180

ctaatgtgat ctccccactt tcacataaga tggtggccct gccttcaggg aatgtgggag   6240

ccaggtggga gccttcccgg atatttaagc tagaagattc tacagggaga ttctccttgg   6300

atcaatatat gtctctcagt caaagatgta aaagcacttt tgccttaaaa agaatgttct   6360

gtttctaaat agagtcaacg ttgtcctcct cattggaatt cactatgagt cagaatcatt   6420

agactgactt ttttttttcc atagtaatag tattttgcag agtctcacag agctgcagat   6480

cttttgttca tcttgcagag ttaacaagtc tgatcctgtt agtccagatt tcttaaattt   6540

ggccaagtta taataggagc agtagcttga gacccgaagt caggaaactt tgacaatgga   6600

tttttttttt taatccagag acttgtactg gaatttgcct taccctgtca gctcatggac   6660

ttaaggtttc atcccgcttt atgagtgctt ctgaatccaa gtcattgtta cctgaatttg   6720

caaattaagt tgtgatattc gtgactgtta aattcctgta attagattaa cctctttgct   6780

tgcttgtttg ttttctctcc tattttagct taaagtatca gtggttgaga agagcttttc   6840

ggacctgtta ctaccccaag ctgtgtaata tacttgtata acagaaatac cttctataca   6900

aacctttttt tctactttta gatagaaatg tctacttttt cagcagttct gtgaattaaa   6960

gagcagagtg actgtgggtc tggaatggct ggtgtacttg ggaatgtact atcaggattt   7020

tacagcaatg ctgggaaatg acagggaaaa tgacaggaat gaatctcacc agatttttta   7080

tgtactcagc agagccttga gttacggtgt ttattttcca atcaagtgaa gatatctcct   7140

acttctccta ctggaacatc tcagcttctg cagtgaagaa aaattcctgt gatagttcag   7200

ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa tgatcctttg ttcacggctc   7260

tccttaatga ctgagtgaac agttcctatc tgtatatttg actaaacctt ttcctaagct   7320

atctctcatg gttcctatgt ttttttatca taattaaaag caaaaccatc tggatcacct   7380

aacagtcaga ggtcagtatc tcagcgtgtg aattatagag gaaatacaga gagaacctct   7440

tccactttta cttttcgtcc aaataaaatg catggtgtac cagaagttga agatcgggtt   7500

gaggattggg gctagctcga tgacactaag gccccaacat cgcgggacct gctgtggcgc   7560

ggattcttag gaacgctgtt ctagccggcc ccctctccag gggtcgccgt ggccggcatt   7620

atttcctagt tcttcttgta accctgaggt gccagcgcgg ggagtgagga ggggtcaggg   7680

ggctaaggat gcaacctctg acgttctgcg ccttcctagg agagtcttac atgtgttgag   7740

atttcacaag caatgcgagt tgtaaaatac cagctctaca agaagctagg ctctgtgacg   7800

gcatagtttt cagtagcttt atcacaatat tcacaatgga gaattatatg acatggtagc   7860

agaaataggc ccttttatgt gttgcttcta ttttacctca aattgtagat atagggtaat   7920

caataaaatc catccatgcc tttcacacac taagt                              7955


<210>  4361
<211>  922
<212>  PRT
<213>  Homo sapiens

<400>  4361

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu 
            580                 585                 590


Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg 
        595                 600                 605


Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys 
    610                 615                 620


Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys 
625                 630                 635                 640


Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly 
                645                 650                 655


Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn 
            660                 665                 670


Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn 
        675                 680                 685


Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu 
    690                 695                 700


Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu 
705                 710                 715                 720


Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys 
                725                 730                 735


Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu 
            740                 745                 750


Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile 
        755                 760                 765


Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile 
    770                 775                 780


Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser 
785                 790                 795                 800


Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr 
                805                 810                 815


Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro 
            820                 825                 830


Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu 
        835                 840                 845


Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile 
    850                 855                 860


Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn 
865                 870                 875                 880


Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys 
                885                 890                 895


Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser 
            900                 905                 910


Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
        915                 920


<210>  4362
<211>  7868
<212>  DNA
<213>  Homo sapiens

<400>  4362
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1980

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   2040

catatcctgt gtttgaatca aacccggagt tcttgtatgt ggaaggcttg ccagagggga   2100

ttcccttccg aagccctacc tggtttggaa ttccacgact tgaaaggatc gtccgcggga   2160

gtaataaaat caagttcgtt gttaaaaaac ctgaactagt tatttcctac ttgcctcctg   2220

ggatggctag taaaataaac actaaagctt tgcagtcccc caaaagacca cgaagtcctg   2280

ggagtaattc aaaggttcct gaaattgagg tcaccgtgga aggccctaat aacaacaatc   2340

ctcaaacctc agctgttcga accccgaccc agactaacgg ttctaacgtt cccttcaagc   2400

cacgagggag agagttttcc tttgaggcct ggaatgccaa aatcacggac ctaaaacaga   2460

aagttgaaaa tctcttcaat gagaaatgtg gggaagctct tggccttaaa caagctgtga   2520

aggtgccgtt cgcgttattt gagtctttcc cggaagactt ttatgtggaa ggcttacctg   2580

agggtgtgcc attccgaaga ccatcgactt ttggcattcc gaggctggag aagatactca   2640

gaaacaaagc caaaattaag ttcatcatta aaaagcccga aatgtttgag acggcgatta   2700

aggagagcac ctcctctaag agccctccca gaaaaataaa ttcatcaccc aatgttaata   2760

ctactgcatc aggtgttgaa gaccttaaca tcattcaggt gacaattcca gatgatgata   2820

atgaaagact ctcgaaagtt gaaaaagcta gacagctaag agaacaagtg aatgacctct   2880

ttagtcggaa atttggtgaa gctattggta tgggttttcc tgtgaaagtt ccctacagga   2940

aaatcacaat taaccctggc tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca   3000

aagcccccag ctacctggaa atcagctcca tgagaaggat cttagactct gccgagttta   3060

tcaaattcac ggtcattagg taagtgagag tttcctgctt agtcacagga gcgaatctgg   3120

agctcatgag gctgactctt ctaaaatgca gccacaggta gtcatcgaat ccggcttcct   3180

atgctgtgca atcaacaaat caaaataact tgtgtcatca ttagaatgtc agatgtgctt   3240

ctacgaacta agctgactct tttaattctt tggcaaaggg ttggcaaact aggactgttt   3300

gccaaattca ggctgcctcc tatttttaga gtcttcctga aacacagcta cacccgtatt   3360

atccatggct gctttcctgt cacagtgagt aagtagctgg gactgagaag gcatggcctc   3420

caaagtctaa aatatttact ctctagcact ttgtagaaaa accttagcta ggcacagtgg   3480

ctaacgcctg taatcccagc attttgggag gccaaggcag gcagatcacc tgaggtcagg   3540

agttccagac cagcctggcc aacatggtga aatcccatct ctacaaaaat aaaacagtta   3600

gctgggcatg atggcgggtg cctgtaatcc cagctactcg ggaggctgag gcaggatagt   3660

cgcttgaacc caggaggtgg aggttgcaat gagccaagat catgccactg cactccagcc   3720

tggacgacag agtgagactc catcacaaga aaaaaagaac tttgtcaacc tctgtcttag   3780

ggcgccttgt cacaggcttc gggtcagacg gattcaacct tgcatcagcc atttgttagc   3840

caggtcactc tgttctttgt ctgtaaatga gattgatcgt tgttcccact gagagtgtca   3900

gctccttccc gtagagcagg catgatgatt gtactcacct ctgacaccat tgtgagtgcc   3960

acattccttc ccacgtcctt gtcactgtaa gagatgccca cctgagcacc aaccccaggt   4020

tatcttcccc tttgtcttcc agccccccag aaacagctac gactcaacct acccaatcat   4080

ttcatcatca gattgccact gtctctagtt caggtctctt gggactggca ctcagaaatc   4140

tcataataaa tcctcttgag gcttctcata cactcgtctt cttccaatct tctttccctc   4200

aaaatctcat attttggttc cacttcaccc accgtcattc tccatatcac tcccaggagt   4260

taggcaaaaa gccccttccg ttcttccgta tgttaaactt agaatcactc tgttccctgc   4320

tctgcgtttc tattttttgt ttttcctcca tttactagta gcttaacact ttctaacagt   4380

gttcttatta ttgatacgta tctatctctt ccataagctt ataaggtcac ggataatact   4440

tctcattgta gtacgtaaat gacgtgggct agatatgagt tgaataaaca gttatacctg   4500

taaattctta cagagtgaaa ataaattgtt atactttaca atttgtttct ctctttagac   4560

catttccagg acttgtgatt aataaccgtg agtattttgt gaagtgtttt gtttttgttt   4620

tttcctgggg tctgacgtgt gtgcgtgtga gtgtgtatac atgcttaacg tatatcacgt   4680

tacttcacct atgtcagtaa ccaggccaaa tacttgtttt agccctcagt aaaaacacca   4740

ggcacttcct agttgtaaaa ttattcaagc ttcttaactt cctatcctcg atgcacttaa   4800

tcataaaatg gtaataatag caccgatttt gggggagtcg ttccagtaga tggaaagcat   4860

ctggaacagg tgtcagcaag ctcctgccga cgtgtatgca taaagtttta ttgaaaccac   4920

catcgtgtcc atttgtttat ggcagaactg agagatggca gcagcaagtg tgtgcctgca   4980

aaacctaaaa tatttactaa ttggctctgc aagaaaagag tttgcatccc cctaacctag   5040

aacagtgtct agcctctagt atgtgtttag cctacagtat gtgctcagcg aatacaatct   5100

atatttatta ctgcttttat gactgttata attactgtgc ttggatttcg ttacaaagta   5160

agtcacaatg tgcctgcttc tgttagtatt tcagcacagt gcctggcaca catggggctc   5220

tcaaatattg ctgagcgagt gaacaaatgt cctttcaatt ccttaacgtt gatgtcattt   5280

tcaatagtat tttgagccaa acttaatttt gcgagtgtgt tttgttttct taactttatt   5340

attaaaaatg tataaaagtg aggccaggcg tggtggctca cgcctgtaat cccagcagtt   5400

tgggaggctg aggcaggcgg atcagttgag gttgggagtt ggagaccagc ccgtccaaca   5460

tggtgaaagc ctgtctctac taaaaataca aaaatcagct gggtgtggtg gcgcgtgcct   5520

gtaatcccag ctactcagga ggctgaggca ggagagttgc ttgaatccta gaggtggagg   5580

ttgcagtgag ctgagatcgt gccattgcac tccagcctgg gcaacaagag caaaactctg   5640

tcccaataaa taaataaata aaatgttctc ttttgttcct gttcttgtgc ggtagtgtgg   5700

tatagagttt tatggtaatt actgtgaatt agtgattctg agggacatat cagaactctg   5760

aggtttgttt ccttctcatc ttgagggaaa cagcaaatgt atgttaaaat gcttttccaa   5820

gggaacaaca catccttaca ttatttaaac caatctgctt cattttcaga gctggttgat   5880

cagagtgagt cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt   5940

ccagccacag aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac   6000

cccacgtggt agacctcttc cctcctaggg taaatcagct tctgtgtcag ggatgctgtg   6060

tggtgtccat ctgaaccccc tgcatacgcg tagctaatgt gatctcccca ctttcacata   6120

agatggtggc cctgccttca gggaatgtgg gagccaggtg ggagccttcc cggatattta   6180

agctagaaga ttctacaggg agattctcct tggatcaata tatgtctctc agtcaaagat   6240

gtaaaagcac ttttgcctta aaaagaatgt tctgtttcta aatagagtca acgttgtcct   6300

cctcattgga attcactatg agtcagaatc attagactga cttttttttt tccatagtaa   6360

tagtattttg cagagtctca cagagctgca gatcttttgt tcatcttgca gagttaacaa   6420

gtctgatcct gttagtccag atttcttaaa tttggccaag ttataatagg agcagtagct   6480

tgagacccga agtcaggaaa ctttgacaat ggattttttt ttttaatcca gagacttgta   6540

ctggaatttg ccttaccctg tcagctcatg gacttaaggt ttcatcccgc tttatgagtg   6600

cttctgaatc caagtcattg ttacctgaat ttgcaaatta agttgtgata ttcgtgactg   6660

ttaaattcct gtaattagat taacctcttt gcttgcttgt ttgttttctc tcctatttta   6720

gcttaaagta tcagtggttg agaagagctt ttcggacctg ttactacccc aagctgtgta   6780

atatacttgt ataacagaaa taccttctat acaaaccttt ttttctactt ttagatagaa   6840

atgtctactt tttcagcagt tctgtgaatt aaagagcaga gtgactgtgg gtctggaatg   6900

gctggtgtac ttgggaatgt actatcagga ttttacagca atgctgggaa atgacaggga   6960

aaatgacagg aatgaatctc accagatttt ttatgtactc agcagagcct tgagttacgg   7020

tgtttatttt ccaatcaagt gaagatatct cctacttctc ctactggaac atctcagctt   7080

ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa   7140

aaaatcattt aaatgatcct ttgttcacgg ctctccttaa tgactgagtg aacagttcct   7200

atctgtatat ttgactaaac cttttcctaa gctatctctc atggttccta tgttttttta   7260

tcataattaa aagcaaaacc atctggatca cctaacagtc agaggtcagt atctcagcgt   7320

gtgaattata gaggaaatac agagagaacc tcttccactt ttacttttcg tccaaataaa   7380

atgcatggtg taccagaagt tgaagatcgg gttgaggatt ggggctagct cgatgacact   7440

aaggccccaa catcgcggga cctgctgtgg cgcggattct taggaacgct gttctagccg   7500

gccccctctc caggggtcgc cgtggccggc attatttcct agttcttctt gtaaccctga   7560

ggtgccagcg cggggagtga ggaggggtca gggggctaag gatgcaacct ctgacgttct   7620

gcgccttcct aggagagtct tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa   7680

taccagctct acaagaagct aggctctgtg acggcatagt tttcagtagc tttatcacaa   7740

tattcacaat ggagaattat atgacatggt agcagaaata ggccctttta tgtgttgctt   7800

ctattttacc tcaaattgta gatatagggt aatcaataaa atccatccat gcctttcaca   7860

cactaagt                                                            7868


<210>  4363
<211>  832
<212>  PRT
<213>  Homo sapiens

<400>  4363

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
    450                 455                 460


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
465                 470                 475                 480


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
                485                 490                 495


Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr 
            500                 505                 510


Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys 
        515                 520                 525


Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro 
    530                 535                 540


Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys 
545                 550                 555                 560


Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val 
                565                 570                 575


Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg 
            580                 585                 590


Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly 
        595                 600                 605


Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys 
    610                 615                 620


Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly 
625                 630                 635                 640


Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro 
                645                 650                 655


Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg 
            660                 665                 670


Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys 
        675                 680                 685


Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala 
    690                 695                 700


Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser 
705                 710                 715                 720


Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile 
                725                 730                 735


Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val 
            740                 745                 750


Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg 
        755                 760                 765


Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr 
    770                 775                 780


Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro 
785                 790                 795                 800


Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met 
                805                 810                 815


Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
            820                 825                 830


<210>  4364
<211>  4190
<212>  DNA
<213>  Homo sapiens

<400>  4364
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040

taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2100

ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2160

ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2220

ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2280

ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2340

atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2400

agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2460

agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2520

tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2580

ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2640

tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2700

ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2760

atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2820

ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2880

tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   2940

ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   3000

tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3060

ttatcaaatt cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg   3120

atcagagtga gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag   3180

ttccagccac agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag   3240

accccacgtg gtagacctct tccctcctag gcttaaagta tcagtggttg agaagagctt   3300

ttcggacctg ttactacccc aagctgtagc cttgagttac ggtgtttatt ttccaatcaa   3360

gtgaagatat ctcctacttc tcctactgga acatctcagc ttctgcagtg aagaaaaatt   3420

cctgtgatag ttcagttctt tagtttttct atttgaaaaa aaaaaatcat ttaaatgatc   3480

ctttgttcac ggctctcctt aatgactgag tgaacagttc ctatctgtat atttgactaa   3540

accttttcct aagctatctc tcatggttcc tatgtttttt tatcataatt aaaagcaaaa   3600

ccatctggat cacctaacag tcagaggtca gtatctcagc gtgtgaatta tagaggaaat   3660

acagagagaa cctcttccac ttttactttt cgtccaaata aaatgcatgg tgtaccagaa   3720

gttgaagatc gggttgagga ttggggctag ctcgatgaca ctaaggcccc aacatcgcgg   3780

gacctgctgt ggcgcggatt cttaggaacg ctgttctagc cggccccctc tccaggggtc   3840

gccgtggccg gcattatttc ctagttcttc ttgtaaccct gaggtgccag cgcggggagt   3900

gaggaggggt cagggggcta aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt   3960

cttacatgtg ttgagatttc acaagcaatg cgagttgtaa aataccagct ctacaagaag   4020

ctaggctctg tgacggcata gttttcagta gctttatcac aatattcaca atggagaatt   4080

atatgacatg gtagcagaaa taggcccttt tatgtgttgc ttctatttta cctcaaattg   4140

tagatatagg gtaatcaata aaatccatcc atgcctttca cacactaagt              4190


<210>  4365
<211>  889
<212>  PRT
<213>  Homo sapiens

<400>  4365

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
    450                 455                 460


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
465                 470                 475                 480


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
                485                 490                 495


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
            500                 505                 510


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
        515                 520                 525


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
    530                 535                 540


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
545                 550                 555                 560


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
                565                 570                 575


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
            580                 585                 590


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
        595                 600                 605


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
    610                 615                 620


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
625                 630                 635                 640


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
                645                 650                 655


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
            660                 665                 670


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
        675                 680                 685


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
    690                 695                 700


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
705                 710                 715                 720


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
                725                 730                 735


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
            740                 745                 750


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
        755                 760                 765


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
    770                 775                 780


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
785                 790                 795                 800


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
                805                 810                 815


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
            820                 825                 830


Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser 
        835                 840                 845


Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu 
    850                 855                 860


Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln 
865                 870                 875                 880


Ile Lys Gln Glu Pro Asp Pro Thr Trp 
                885


<210>  4366
<211>  7903
<212>  DNA
<213>  Homo sapiens

<400>  4366
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagc   2040

tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc   2100

ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc ctacctggtt   2160

tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa   2220

aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa taaacactaa   2280

agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg ttcctgaaat   2340

tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg ttcgaacccc   2400

gacccagact aacggttcta acgttccctt caagccacga gggagagagt tttcctttga   2460

ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct tcaatgagaa   2520

atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc   2580

tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc gaagaccatc   2640

gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa ttaagttcat   2700

cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct ctaagagccc   2760

tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg ttgaagacct   2820

taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga aagttgaaaa   2880

agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg gtgaagctat   2940

tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc ctggctgtgt   3000

ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc tggaaatcag   3060

ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca ttaggtaagt   3120

gagagtttcc tgcttagtca caggagcgaa tctggagctc atgaggctga ctcttctaaa   3180

atgcagccac aggtagtcat cgaatccggc ttcctatgct gtgcaatcaa caaatcaaaa   3240

taacttgtgt catcattaga atgtcagatg tgcttctacg aactaagctg actcttttaa   3300

ttctttggca aagggttggc aaactaggac tgtttgccaa attcaggctg cctcctattt   3360

ttagagtctt cctgaaacac agctacaccc gtattatcca tggctgcttt cctgtcacag   3420

tgagtaagta gctgggactg agaaggcatg gcctccaaag tctaaaatat ttactctcta   3480

gcactttgta gaaaaacctt agctaggcac agtggctaac gcctgtaatc ccagcatttt   3540

gggaggccaa ggcaggcaga tcacctgagg tcaggagttc cagaccagcc tggccaacat   3600

ggtgaaatcc catctctaca aaaataaaac agttagctgg gcatgatggc gggtgcctgt   3660

aatcccagct actcgggagg ctgaggcagg atagtcgctt gaacccagga ggtggaggtt   3720

gcaatgagcc aagatcatgc cactgcactc cagcctggac gacagagtga gactccatca   3780

caagaaaaaa agaactttgt caacctctgt cttagggcgc cttgtcacag gcttcgggtc   3840

agacggattc aaccttgcat cagccatttg ttagccaggt cactctgttc tttgtctgta   3900

aatgagattg atcgttgttc ccactgagag tgtcagctcc ttcccgtaga gcaggcatga   3960

tgattgtact cacctctgac accattgtga gtgccacatt ccttcccacg tccttgtcac   4020

tgtaagagat gcccacctga gcaccaaccc caggttatct tcccctttgt cttccagccc   4080

cccagaaaca gctacgactc aacctaccca atcatttcat catcagattg ccactgtctc   4140

tagttcaggt ctcttgggac tggcactcag aaatctcata ataaatcctc ttgaggcttc   4200

tcatacactc gtcttcttcc aatcttcttt ccctcaaaat ctcatatttt ggttccactt   4260

cacccaccgt cattctccat atcactccca ggagttaggc aaaaagcccc ttccgttctt   4320

ccgtatgtta aacttagaat cactctgttc cctgctctgc gtttctattt tttgtttttc   4380

ctccatttac tagtagctta acactttcta acagtgttct tattattgat acgtatctat   4440

ctcttccata agcttataag gtcacggata atacttctca ttgtagtacg taaatgacgt   4500

gggctagata tgagttgaat aaacagttat acctgtaaat tcttacagag tgaaaataaa   4560

ttgttatact ttacaatttg tttctctctt tagaccattt ccaggacttg tgattaataa   4620

ccgtgagtat tttgtgaagt gttttgtttt tgttttttcc tggggtctga cgtgtgtgcg   4680

tgtgagtgtg tatacatgct taacgtatat cacgttactt cacctatgtc agtaaccagg   4740

ccaaatactt gttttagccc tcagtaaaaa caccaggcac ttcctagttg taaaattatt   4800

caagcttctt aacttcctat cctcgatgca cttaatcata aaatggtaat aatagcaccg   4860

attttggggg agtcgttcca gtagatggaa agcatctgga acaggtgtca gcaagctcct   4920

gccgacgtgt atgcataaag ttttattgaa accaccatcg tgtccatttg tttatggcag   4980

aactgagaga tggcagcagc aagtgtgtgc ctgcaaaacc taaaatattt actaattggc   5040

tctgcaagaa aagagtttgc atccccctaa cctagaacag tgtctagcct ctagtatgtg   5100

tttagcctac agtatgtgct cagcgaatac aatctatatt tattactgct tttatgactg   5160

ttataattac tgtgcttgga tttcgttaca aagtaagtca caatgtgcct gcttctgtta   5220

gtatttcagc acagtgcctg gcacacatgg ggctctcaaa tattgctgag cgagtgaaca   5280

aatgtccttt caattcctta acgttgatgt cattttcaat agtattttga gccaaactta   5340

attttgcgag tgtgttttgt tttcttaact ttattattaa aaatgtataa aagtgaggcc   5400

aggcgtggtg gctcacgcct gtaatcccag cagtttggga ggctgaggca ggcggatcag   5460

ttgaggttgg gagttggaga ccagcccgtc caacatggtg aaagcctgtc tctactaaaa   5520

atacaaaaat cagctgggtg tggtggcgcg tgcctgtaat cccagctact caggaggctg   5580

aggcaggaga gttgcttgaa tcctagaggt ggaggttgca gtgagctgag atcgtgccat   5640

tgcactccag cctgggcaac aagagcaaaa ctctgtccca ataaataaat aaataaaatg   5700

ttctcttttg ttcctgttct tgtgcggtag tgtggtatag agttttatgg taattactgt   5760

gaattagtga ttctgaggga catatcagaa ctctgaggtt tgtttccttc tcatcttgag   5820

ggaaacagca aatgtatgtt aaaatgcttt tccaagggaa caacacatcc ttacattatt   5880

taaaccaatc tgcttcattt tcagagctgg ttgatcagag tgagtcagaa ggccccgtga   5940

tacaagaatc agctgaacca agccagttgg aagttccagc cacagaagaa ataaaagaga   6000

ctgatggaag ctctcagatc aagcaagaac cagaccccac gtggtagacc tcttccctcc   6060

tagggtaaat cagcttctgt gtcagggatg ctgtgtggtg tccatctgaa ccccctgcat   6120

acgcgtagct aatgtgatct ccccactttc acataagatg gtggccctgc cttcagggaa   6180

tgtgggagcc aggtgggagc cttcccggat atttaagcta gaagattcta cagggagatt   6240

ctccttggat caatatatgt ctctcagtca aagatgtaaa agcacttttg ccttaaaaag   6300

aatgttctgt ttctaaatag agtcaacgtt gtcctcctca ttggaattca ctatgagtca   6360

gaatcattag actgactttt ttttttccat agtaatagta ttttgcagag tctcacagag   6420

ctgcagatct tttgttcatc ttgcagagtt aacaagtctg atcctgttag tccagatttc   6480

ttaaatttgg ccaagttata ataggagcag tagcttgaga cccgaagtca ggaaactttg   6540

acaatggatt ttttttttta atccagagac ttgtactgga atttgcctta ccctgtcagc   6600

tcatggactt aaggtttcat cccgctttat gagtgcttct gaatccaagt cattgttacc   6660

tgaatttgca aattaagttg tgatattcgt gactgttaaa ttcctgtaat tagattaacc   6720

tctttgcttg cttgtttgtt ttctctccta ttttagctta aagtatcagt ggttgagaag   6780

agcttttcgg acctgttact accccaagct gtgtaatata cttgtataac agaaatacct   6840

tctatacaaa cctttttttc tacttttaga tagaaatgtc tactttttca gcagttctgt   6900

gaattaaaga gcagagtgac tgtgggtctg gaatggctgg tgtacttggg aatgtactat   6960

caggatttta cagcaatgct gggaaatgac agggaaaatg acaggaatga atctcaccag   7020

attttttatg tactcagcag agccttgagt tacggtgttt attttccaat caagtgaaga   7080

tatctcctac ttctcctact ggaacatctc agcttctgca gtgaagaaaa attcctgtga   7140

tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat catttaaatg atcctttgtt   7200

cacggctctc cttaatgact gagtgaacag ttcctatctg tatatttgac taaacctttt   7260

cctaagctat ctctcatggt tcctatgttt ttttatcata attaaaagca aaaccatctg   7320

gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa ttatagagga aatacagaga   7380

gaacctcttc cacttttact tttcgtccaa ataaaatgca tggtgtacca gaagttgaag   7440

atcgggttga ggattggggc tagctcgatg acactaaggc cccaacatcg cgggacctgc   7500

tgtggcgcgg attcttagga acgctgttct agccggcccc ctctccaggg gtcgccgtgg   7560

ccggcattat ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg   7620

ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc ttcctaggag agtcttacat   7680

gtgttgagat ttcacaagca atgcgagttg taaaatacca gctctacaag aagctaggct   7740

ctgtgacggc atagttttca gtagctttat cacaatattc acaatggaga attatatgac   7800

atggtagcag aaataggccc ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat   7860

agggtaatca ataaaatcca tccatgcctt tcacacacta agt                     7903


<210>  4367
<211>  898
<212>  PRT
<213>  Homo sapiens

<400>  4367

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly 
    530                 535                 540


Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro 
545                 550                 555                 560


Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser 
                565                 570                 575


Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser 
            580                 585                 590


Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr 
        595                 600                 605


Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser 
    610                 615                 620


Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile 
625                 630                 635                 640


Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala 
                645                 650                 655


Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro 
            660                 665                 670


Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp 
        675                 680                 685


Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala 
    690                 695                 700


Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser 
705                 710                 715                 720


Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe 
                725                 730                 735


Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg 
            740                 745                 750


Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu 
        755                 760                 765


Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile 
    770                 775                 780


Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu 
785                 790                 795                 800


Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser 
                805                 810                 815


Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe 
            820                 825                 830


Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val 
        835                 840                 845


Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly 
    850                 855                 860


Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser 
865                 870                 875                 880


Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val 
                885                 890                 895


Ile Arg 



<210>  4368
<211>  4158
<212>  DNA
<213>  Homo sapiens

<400>  4368
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   1980

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2040

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2100

tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg tttggaattc   2160

cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg   2220

aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc   2280

agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca   2340

ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga   2400

ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga   2460

atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg   2520

aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg   2580

aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg   2640

gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa   2700

agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa   2760

aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca   2820

ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac   2880

agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg   2940

gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg   3000

atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga   3060

gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca tttccaggac   3120

ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat   3180

cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa   3240

gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc ctaggagcct   3300

tgagttacgg tgtttatttt ccaatcaagt gaagatatct cctacttctc ctactggaac   3360

atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta gtttttctat   3420

ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg ctctccttaa tgactgagtg   3480

aacagttcct atctgtatat ttgactaaac cttttcctaa gctatctctc atggttccta   3540

tgttttttta tcataattaa aagcaaaacc atctggatca cctaacagtc agaggtcagt   3600

atctcagcgt gtgaattata gaggaaatac agagagaacc tcttccactt ttacttttcg   3660

tccaaataaa atgcatggtg taccagaagt tgaagatcgg gttgaggatt ggggctagct   3720

cgatgacact aaggccccaa catcgcggga cctgctgtgg cgcggattct taggaacgct   3780

gttctagccg gccccctctc caggggtcgc cgtggccggc attatttcct agttcttctt   3840

gtaaccctga ggtgccagcg cggggagtga ggaggggtca gggggctaag gatgcaacct   3900

ctgacgttct gcgccttcct aggagagtct tacatgtgtt gagatttcac aagcaatgcg   3960

agttgtaaaa taccagctct acaagaagct aggctctgtg acggcatagt tttcagtagc   4020

tttatcacaa tattcacaat ggagaattat atgacatggt agcagaaata ggccctttta   4080

tgtgttgctt ctattttacc tcaaattgta gatatagggt aatcaataaa atccatccat   4140

gcctttcaca cactaagt                                                 4158


<210>  4369
<211>  958
<212>  PRT
<213>  Homo sapiens

<400>  4369

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile 
        515                 520                 525


Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
545                 550                 555                 560


Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile 
                565                 570                 575


Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile 
            580                 585                 590


Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu 
        595                 600                 605


Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys 
    610                 615                 620


Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys 
625                 630                 635                 640


Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro 
                645                 650                 655


Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val 
            660                 665                 670


Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala 
        675                 680                 685


Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys 
    690                 695                 700


Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala 
705                 710                 715                 720


Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu 
                725                 730                 735


Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu 
            740                 745                 750


Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro 
        755                 760                 765


Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro 
    770                 775                 780


Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly 
785                 790                 795                 800


Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn 
                805                 810                 815


Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val 
            820                 825                 830


Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe 
        835                 840                 845


Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val 
    850                 855                 860


Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr 
865                 870                 875                 880


Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile 
                885                 890                 895


Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln 
            900                 905                 910


Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala 
        915                 920                 925


Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr 
    930                 935                 940


Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950                 955


<210>  4370
<211>  4933
<212>  DNA
<213>  Homo sapiens

<400>  4370
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gctcaagctc ttggactcac cgaggcagta aaagtaccat   1920

atcctgtgtt tgaatcaaac ccggagttct tgtatgtgga aggcttgcca gaggggattc   1980

ccttccgaag ccctacctgg tttggaattc cacgacttga aaggatcgtc cgcgggagta   2040

ataaaatcaa gttcgttgtt aaaaaacctg aactagttat ttcctacttg cctcctggga   2100

tggctagtaa aataaacact aaagctttgc agtcccccaa aagaccacga agtcctggga   2160

gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg ccctaataac aacaatcctc   2220

aaacctcagc tgttcgaacc ccgacccaga ctaacggttc taacgttccc ttcaagccac   2280

gagggagaga gttttccttt gaggcctgga atgccaaaat cacggaccta aaacagaaag   2340

ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg   2400

tgccgttcgc gttatttgag tctttcccgg aagactttta tgtggaaggc ttacctgagg   2460

gtgtgccatt ccgaagacca tcgacttttg gcattccgag gctggagaag atactcagaa   2520

acaaagccaa aattaagttc atcattaaaa agcccgaaat gtttgagacg gcgattaagg   2580

agagcacctc ctctaagagc cctcccagaa aaataaattc atcacccaat gttaatacta   2640

ctgcatcagg tgttgaagac cttaacatca ttcaggtgac aattccagat gatgataatg   2700

aaagactctc gaaagttgaa aaagctagac agctaagaga acaagtgaat gacctcttta   2760

gtcggaaatt tggtgaagct attggtatgg gttttcctgt gaaagttccc tacaggaaaa   2820

tcacaattaa ccctggctgt gtggtggttg atggcatgcc cccgggggtg tccttcaaag   2880

cccccagcta cctggaaatc agctccatga gaaggatctt agactctgcc gagtttatca   2940

aattcacggt cattagacca tttccaggac ttgtgattaa taaccagctg gttgatcaga   3000

gtgagtcaga aggccccgtg atacaagaat cagctgaacc aagccagttg gaagttccag   3060

ccacagaagg taaaaggacc tcttccctcc tagggtaaat cagcttctgt gtcagggatg   3120

ctgtgtggtg tccatctgaa ccccctgcat acgcgtagct aatgtgatct ccccactttc   3180

acataagatg gtggccctgc cttcagggaa tgtgggagcc aggtgggagc cttcccggat   3240

atttaagcta gaagattcta cagggagatt ctccttggat caatatatgt ctctcagtca   3300

aagatgtaaa agcacttttg ccttaaaaag aatgttctgt ttctaaatag agtcaacgtt   3360

gtcctcctca ttggaattca ctatgagtca gaatcattag actgactttt ttttttccat   3420

agtaatagta ttttgcagag tctcacagag ctgcagatct tttgttcatc ttgcagagtt   3480

aacaagtctg atcctgttag tccagatttc ttaaatttgg ccaagttata ataggagcag   3540

tagcttgaga cccgaagtca ggaaactttg acaatggatt ttttttttta atccagagac   3600

ttgtactgga atttgcctta ccctgtcagc tcatggactt aaggtttcat cccgctttat   3660

gagtgcttct gaatccaagt cattgttacc tgaatttgca aattaagttg tgatattcgt   3720

gactgttaaa ttcctgtaat tagattaacc tctttgcttg cttgtttgtt ttctctccta   3780

ttttagctta aagtatcagt ggttgagaag agcttttcgg acctgttact accccaagct   3840

gtgtaatata cttgtataac agaaatacct tctatacaaa cctttttttc tacttttaga   3900

tagaaatgtc tactttttca gcagttctgt gaattaaaga gcagagtgac tgtgggtctg   3960

gaatggctgg tgtacttggg aatgtactat caggatttta cagcaatgct gggaaatgac   4020

agggaaaatg acaggaatga atctcaccag attttttatg tactcagcag agccttgagt   4080

tacggtgttt attttccaat caagtgaaga tatctcctac ttctcctact ggaacatctc   4140

agcttctgca gtgaagaaaa attcctgtga tagttcagtt ctttagtttt tctatttgaa   4200

aaaaaaaaat catttaaatg atcctttgtt cacggctctc cttaatgact gagtgaacag   4260

ttcctatctg tatatttgac taaacctttt cctaagctat ctctcatggt tcctatgttt   4320

ttttatcata attaaaagca aaaccatctg gatcacctaa cagtcagagg tcagtatctc   4380

agcgtgtgaa ttatagagga aatacagaga gaacctcttc cacttttact tttcgtccaa   4440

ataaaatgca tggtgtacca gaagttgaag atcgggttga ggattggggc tagctcgatg   4500

acactaaggc cccaacatcg cgggacctgc tgtggcgcgg attcttagga acgctgttct   4560

agccggcccc ctctccaggg gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac   4620

cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc aacctctgac   4680

gttctgcgcc ttcctaggag agtcttacat gtgttgagat ttcacaagca atgcgagttg   4740

taaaatacca gctctacaag aagctaggct ctgtgacggc atagttttca gtagctttat   4800

cacaatattc acaatggaga attatatgac atggtagcag aaataggccc ttttatgtgt   4860

tgcttctatt ttacctcaaa ttgtagatat agggtaatca ataaaatcca tccatgcctt   4920

tcacacacta agt                                                      4933


<210>  4371
<211>  898
<212>  PRT
<213>  Homo sapiens

<400>  4371

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala 
                485                 490                 495


Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser 
            500                 505                 510


Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        515                 520                 525


Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg 
    530                 535                 540


Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile 
545                 550                 555                 560


Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu 
                565                 570                 575


Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro 
            580                 585                 590


Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr 
        595                 600                 605


Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe 
    610                 615                 620


Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile 
625                 630                 635                 640


Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly 
                645                 650                 655


Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe 
            660                 665                 670


Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val 
        675                 680                 685


Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile 
    690                 695                 700


Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met 
705                 710                 715                 720


Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg 
                725                 730                 735


Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu 
            740                 745                 750


Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg 
        755                 760                 765


Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp 
    770                 775                 780


Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val 
785                 790                 795                 800


Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val 
                805                 810                 815


Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu 
            820                 825                 830


Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe 
        835                 840                 845


Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val 
    850                 855                 860


Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro 
865                 870                 875                 880


Ser Gln Leu Glu Val Pro Ala Thr Glu Gly Lys Arg Thr Ser Ser Leu 
                885                 890                 895


Leu Gly 



<210>  4372
<211>  4030
<212>  DNA
<213>  Homo sapiens

<400>  4372
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2100

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2160

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2220

tgaatcaaac ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag   2280

ccctacctgg tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa   2340

gttcgttgtt aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa   2400

aataaacact aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa   2460

ggttcctgaa attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc   2520

tgttcgaacc ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga   2580

gttttccttt gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct   2640

cttcaatgag aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc   2700

gttatttgag tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt   2760

ccgaagacca tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa   2820

aattaagttc atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc   2880

ctctaagagc cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg   2940

tgttgaagac cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc   3000

gaaagttgaa aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt   3060

tggtgaagct attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa   3120

ccctggctgt gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta   3180

cctggaaatc agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt   3240

cattagacca tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga   3300

aggccccgtg atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga   3360

aataaaagag actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac   3420

ctcttccctc ctaggcaaaa ccatctggat cacctaacag tcagaggtca gtatctcagc   3480

gtgtgaatta tagaggaaat acagagagaa cctcttccac ttttactttt cgtccaaata   3540

aaatgcatgg tgtaccagaa gttgaagatc gggttgagga ttggggctag ctcgatgaca   3600

ctaaggcccc aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg ctgttctagc   3660

cggccccctc tccaggggtc gccgtggccg gcattatttc ctagttcttc ttgtaaccct   3720

gaggtgccag cgcggggagt gaggaggggt cagggggcta aggatgcaac ctctgacgtt   3780

ctgcgccttc ctaggagagt cttacatgtg ttgagatttc acaagcaatg cgagttgtaa   3840

aataccagct ctacaagaag ctaggctctg tgacggcata gttttcagta gctttatcac   3900

aatattcaca atggagaatt atatgacatg gtagcagaaa taggcccttt tatgtgttgc   3960

ttctatttta cctcaaattg tagatatagg gtaatcaata aaatccatcc atgcctttca   4020

cacactaagt                                                          4030


<210>  4373
<211>  998
<212>  PRT
<213>  Homo sapiens

<400>  4373

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr 
        595                 600                 605


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe 
    610                 615                 620


Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys 
625                 630                 635                 640


Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly 
                645                 650                 655


Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro 
            660                 665                 670


Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val 
        675                 680                 685


Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro 
    690                 695                 700


Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu 
705                 710                 715                 720


Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys 
                725                 730                 735


Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys 
            740                 745                 750


Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp 
        755                 760                 765


Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser 
    770                 775                 780


Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys 
785                 790                 795                 800


Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys 
                805                 810                 815


Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro 
            820                 825                 830


Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln 
        835                 840                 845


Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys 
    850                 855                 860


Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe 
865                 870                 875                 880


Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys 
                885                 890                 895


Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly 
            900                 905                 910


Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg 
        915                 920                 925


Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe 
    930                 935                 940


Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu 
945                 950                 955                 960


Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro 
                965                 970                 975


Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln 
            980                 985                 990


Glu Pro Asp Pro Thr Trp 
        995


<210>  4374
<211>  4996
<212>  DNA
<213>  Homo sapiens

<400>  4374
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1980

catatcctgt gtttgaatca aacccggagt tcttgtatgt ggaaggcttg ccagagggga   2040

ttcccttccg aagccctacc tggtttggaa ttccacgact tgaaaggatc gtccgcggga   2100

gtaataaaat caagttcgtt gttaaaaaac ctgaactagt tatttcctac ttgcctcctg   2160

ggatggctag taaaataaac actaaagctt tgcagtcccc caaaagacca cgaagtcctg   2220

ggagtaattc aaaggttcct gaaattgagg tcaccgtgga aggccctaat aacaacaatc   2280

ctcaaacctc agctgttcga accccgaccc agactaacgg ttctaacgtt cccttcaagc   2340

cacgagggag agagttttcc tttgaggcct ggaatgccaa aatcacggac ctaaaacaga   2400

aagttgaaaa tctcttcaat gagaaatgtg gggaagctct tggccttaaa caagctgtga   2460

aggtgccgtt cgcgttattt gagtctttcc cggaagactt ttatgtggaa ggcttacctg   2520

agggtgtgcc attccgaaga ccatcgactt ttggcattcc gaggctggag aagatactca   2580

gaaacaaagc caaaattaag ttcatcatta aaaagcccga aatgtttgag acggcgatta   2640

aggagagcac ctcctctaag agccctccca gaaaaataaa ttcatcaccc aatgttaata   2700

ctactgcatc aggtgttgaa gaccttaaca tcattcaggt gacaattcca gatgatgata   2760

atgaaagact ctcgaaagtt gaaaaagcta gacagctaag agaacaagtg aatgacctct   2820

ttagtcggaa atttggtgaa gctattggta tgggttttcc tgtgaaagtt ccctacagga   2880

aaatcacaat taaccctggc tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca   2940

aagcccccag ctacctggaa atcagctcca tgagaaggat cttagactct gccgagttta   3000

tcaaattcac ggtcattaga ccatttccag gacttgtgat taataaccag ctggttgatc   3060

agagtgagtc agaaggcccc gtgatacaag aatcagctga accaagccag ttggaagttc   3120

cagccacaga aggtaaaagg acctcttccc tcctagggta aatcagcttc tgtgtcaggg   3180

atgctgtgtg gtgtccatct gaaccccctg catacgcgta gctaatgtga tctccccact   3240

ttcacataag atggtggccc tgccttcagg gaatgtggga gccaggtggg agccttcccg   3300

gatatttaag ctagaagatt ctacagggag attctccttg gatcaatata tgtctctcag   3360

tcaaagatgt aaaagcactt ttgccttaaa aagaatgttc tgtttctaaa tagagtcaac   3420

gttgtcctcc tcattggaat tcactatgag tcagaatcat tagactgact tttttttttc   3480

catagtaata gtattttgca gagtctcaca gagctgcaga tcttttgttc atcttgcaga   3540

gttaacaagt ctgatcctgt tagtccagat ttcttaaatt tggccaagtt ataataggag   3600

cagtagcttg agacccgaag tcaggaaact ttgacaatgg attttttttt ttaatccaga   3660

gacttgtact ggaatttgcc ttaccctgtc agctcatgga cttaaggttt catcccgctt   3720

tatgagtgct tctgaatcca agtcattgtt acctgaattt gcaaattaag ttgtgatatt   3780

cgtgactgtt aaattcctgt aattagatta acctctttgc ttgcttgttt gttttctctc   3840

ctattttagc ttaaagtatc agtggttgag aagagctttt cggacctgtt actaccccaa   3900

gctgtgtaat atacttgtat aacagaaata ccttctatac aaaccttttt ttctactttt   3960

agatagaaat gtctactttt tcagcagttc tgtgaattaa agagcagagt gactgtgggt   4020

ctggaatggc tggtgtactt gggaatgtac tatcaggatt ttacagcaat gctgggaaat   4080

gacagggaaa atgacaggaa tgaatctcac cagatttttt atgtactcag cagagccttg   4140

agttacggtg tttattttcc aatcaagtga agatatctcc tacttctcct actggaacat   4200

ctcagcttct gcagtgaaga aaaattcctg tgatagttca gttctttagt ttttctattt   4260

gaaaaaaaaa aatcatttaa atgatccttt gttcacggct ctccttaatg actgagtgaa   4320

cagttcctat ctgtatattt gactaaacct tttcctaagc tatctctcat ggttcctatg   4380

tttttttatc ataattaaaa gcaaaaccat ctggatcacc taacagtcag aggtcagtat   4440

ctcagcgtgt gaattataga ggaaatacag agagaacctc ttccactttt acttttcgtc   4500

caaataaaat gcatggtgta ccagaagttg aagatcgggt tgaggattgg ggctagctcg   4560

atgacactaa ggccccaaca tcgcgggacc tgctgtggcg cggattctta ggaacgctgt   4620

tctagccggc cccctctcca ggggtcgccg tggccggcat tatttcctag ttcttcttgt   4680

aaccctgagg tgccagcgcg gggagtgagg aggggtcagg gggctaagga tgcaacctct   4740

gacgttctgc gccttcctag gagagtctta catgtgttga gatttcacaa gcaatgcgag   4800

ttgtaaaata ccagctctac aagaagctag gctctgtgac ggcatagttt tcagtagctt   4860

tatcacaata ttcacaatgg agaattatat gacatggtag cagaaatagg cccttttatg   4920

tgttgcttct attttacctc aaattgtaga tatagggtaa tcaataaaat ccatccatgc   4980

ctttcacaca ctaagt                                                   4996


<210>  4375
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  4375

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
            420                 425                 430


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
        435                 440                 445


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
    450                 455                 460


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu 
465                 470                 475                 480


Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile 
                485                 490                 495


Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val 
            500                 505                 510


Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala 
        515                 520                 525


Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser 
    530                 535                 540


Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly 
545                 550                 555                 560


Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln 
                565                 570                 575


Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser 
            580                 585                 590


Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu 
        595                 600                 605


Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala 
    610                 615                 620


Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr 
625                 630                 635                 640


Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe 
                645                 650                 655


Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys 
            660                 665                 670


Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser 
        675                 680                 685


Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val 
    690                 695                 700


Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr 
705                 710                 715                 720


Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg 
                725                 730                 735


Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu 
            740                 745                 750


Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr 
        755                 760                 765


Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser 
    770                 775                 780


Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu 
785                 790                 795                 800


Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly 
                805                 810                 815


Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro 
            820                 825                 830


Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr 
        835                 840                 845


Glu Gly Lys Arg Thr Ser Ser Leu Leu Gly 
    850                 855


<210>  4376
<211>  4375
<212>  DNA
<213>  Homo sapiens

<400>  4376
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   1980

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2040

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2100

tgaaaggatc gtccgcggga gtaataaaat caagttcgtt gttaaaaaac ctgaactagt   2160

tatttcctac ttgcctcctg ggatggctag taaaataaac actaaagctt tgcagtcccc   2220

caaaagacca cgaagtcctg ggagtaattc aaaggttcct gaaattgagg tcaccgtgga   2280

aggccctaat aacaacaatc ctcaaacctc agctgttcga accccgaccc agactaacgg   2340

ttctaacgtt cccttcaagc cacgagggag agagttttcc tttgaggcct ggaatgccaa   2400

aatcacggac ctaaaacaga aagttgaaaa tctcttcaat gagaaatgtg gggaagctct   2460

tggccttaaa caagctgtga aggtgccgtt cgcgttattt gagtctttcc cggaagactt   2520

ttatgtggaa ggcttacctg agggtgtgcc attccgaaga ccatcgactt ttggcattcc   2580

gaggctggag aagatactca gaaacaaagc caaaattaag ttcatcatta aaaagcccga   2640

aatgtttgag acggcgatta aggagagcac ctcctctaag agccctccca gaaaaataaa   2700

ttcatcaccc aatgttaata ctactgcatc aggtgttgaa gaccttaaca tcattcaggt   2760

gacaattcca gatgatgata atgaaagact ctcgaaagtt gaaaaagcta gacagctaag   2820

agaacaagtg aatgacctct ttagtcggaa atttggtgaa gctattggta tgggttttcc   2880

tgtgaaagtt ccctacagga aaatcacaat taaccctggc tgtgtggtgg ttgatggcat   2940

gcccccgggg gtgtccttca aagcccccag ctacctggaa atcagctcca tgagaaggat   3000

cttagactct gccgagttta tcaaattcac ggtcattaga ccatttccag gacttgtgat   3060

taataaccag ctggttgatc agagtgagtc agaaggcccc gtgatacaag aatcagctga   3120

accaagccag ttggaagttc cagccacaga agaaataaaa gagactgatg gaagctctca   3180

gatcaagcaa gaaccagacc ccacgtggta gacctcttcc ctcctaggct taaagtatca   3240

gtggttgaga agagcttttc ggacctgtta ctaccccaag ctgtgtaata tacttgtata   3300

acagaaatac cttctataca aacctttttt tctactttta gatagaaatg tctacttttt   3360

cagcagttct gtgaattaaa gagcagagtg actgtgggtc tggaatggct ggtgtacttg   3420

ggaatgtact atcaggattt tacagcaatg ctgggaaatg acagggaaaa tgacaggaat   3480

gaatctcacc agatttttta tgtactcagc agagccttga gttacggtgt ttattttcca   3540

atcaagtgaa gatatctcct acttctccta ctggaacatc tcagcttctg cagtgaagaa   3600

aaattcctgt gatagttcag ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa   3660

tgatcctttg ttcacggctc tccttaatga ctgagtgaac agttcctatc tgtatatttg   3720

actaaacctt ttcctaagct atctctcatg gttcctatgt ttttttatca taattaaaag   3780

caaaaccatc tggatcacct aacagtcaga ggtcagtatc tcagcgtgtg aattatagag   3840

gaaatacaga gagaacctct tccactttta cttttcgtcc aaataaaatg catggtgtac   3900

cagaagttga agatcgggtt gaggattggg gctagctcga tgacactaag gccccaacat   3960

cgcgggacct gctgtggcgc ggattcttag gaacgctgtt ctagccggcc ccctctccag   4020

gggtcgccgt ggccggcatt atttcctagt tcttcttgta accctgaggt gccagcgcgg   4080

ggagtgagga ggggtcaggg ggctaaggat gcaacctctg acgttctgcg ccttcctagg   4140

agagtcttac atgtgttgag atttcacaag caatgcgagt tgtaaaatac cagctctaca   4200

agaagctagg ctctgtgacg gcatagtttt cagtagcttt atcacaatat tcacaatgga   4260

gaattatatg acatggtagc agaaataggc ccttttatgt gttgcttcta ttttacctca   4320

aattgtagat atagggtaat caataaaatc catccatgcc tttcacacac taagt        4375


<210>  4377
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  4377

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile 
        515                 520                 525


Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
545                 550                 555                 560


Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys 
                565                 570                 575


Ser Ser Ser Leu Leu Lys Asn Leu Asn 
            580                 585


<210>  4378
<211>  4222
<212>  DNA
<213>  Homo sapiens

<400>  4378
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagc   2040

tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc   2100

ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc ctacctggtt   2160

tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa   2220

aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa taaacactaa   2280

agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg ttcctgaaat   2340

tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg ttcgaacccc   2400

gacccagact aacggttcta acgttccctt caagccacga gggagagagt tttcctttga   2460

ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct tcaatgagaa   2520

atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc   2580

tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc gaagaccatc   2640

gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa ttaagttcat   2700

cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct ctaagagccc   2760

tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg ttgaagacct   2820

taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga aagttgaaaa   2880

agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg gtgaagctat   2940

tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc ctggctgtgt   3000

ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc tggaaatcag   3060

ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca ttagaccatt   3120

tccaggactt gtgattaata accagctggt tgatcagagt gagtcagaag gccccgtgat   3180

acaagaatca gctgaaccaa gccagttgga agttccagcc acagaagaaa taaaagagac   3240

tgatggaagc tctcagatca agcaagaacc agaccccacg tggtagacct cttccctcct   3300

aggcttaaag tatcagtggt tgagaagagc ttttcggacc tgttactacc ccaagctgta   3360

gccttgagtt acggtgttta ttttccaatc aagtgaagat atctcctact tctcctactg   3420

gaacatctca gcttctgcag tgaagaaaaa ttcctgtgat agttcagttc tttagttttt   3480

ctatttgaaa aaaaaaaatc atttaaatga tcctttgttc acggctctcc ttaatgactg   3540

agtgaacagt tcctatctgt atatttgact aaaccttttc ctaagctatc tctcatggtt   3600

cctatgtttt tttatcataa ttaaaagcaa aaccatctgg atcacctaac agtcagaggt   3660

cagtatctca gcgtgtgaat tatagaggaa atacagagag aacctcttcc acttttactt   3720

ttcgtccaaa taaaatgcat ggtgtaccag aagttgaaga tcgggttgag gattggggct   3780

agctcgatga cactaaggcc ccaacatcgc gggacctgct gtggcgcgga ttcttaggaa   3840

cgctgttcta gccggccccc tctccagggg tcgccgtggc cggcattatt tcctagttct   3900

tcttgtaacc ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc taaggatgca   3960

acctctgacg ttctgcgcct tcctaggaga gtcttacatg tgttgagatt tcacaagcaa   4020

tgcgagttgt aaaataccag ctctacaaga agctaggctc tgtgacggca tagttttcag   4080

tagctttatc acaatattca caatggagaa ttatatgaca tggtagcaga aataggccct   4140

tttatgtgtt gcttctattt tacctcaaat tgtagatata gggtaatcaa taaaatccat   4200

ccatgccttt cacacactaa gt                                            4222


<210>  4379
<211>  954
<212>  PRT
<213>  Homo sapiens

<400>  4379

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly 
    530                 535                 540


Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro 
545                 550                 555                 560


Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser 
                565                 570                 575


Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser 
            580                 585                 590


Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr 
        595                 600                 605


Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser 
    610                 615                 620


Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile 
625                 630                 635                 640


Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala 
                645                 650                 655


Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro 
            660                 665                 670


Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp 
        675                 680                 685


Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala 
    690                 695                 700


Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser 
705                 710                 715                 720


Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe 
                725                 730                 735


Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg 
            740                 745                 750


Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu 
        755                 760                 765


Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile 
    770                 775                 780


Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu 
785                 790                 795                 800


Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser 
                805                 810                 815


Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe 
            820                 825                 830


Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val 
        835                 840                 845


Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly 
    850                 855                 860


Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser 
865                 870                 875                 880


Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val 
                885                 890                 895


Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln 
            900                 905                 910


Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln 
        915                 920                 925


Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser 
    930                 935                 940


Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  4380
<211>  4312
<212>  DNA
<213>  Homo sapiens

<400>  4380
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1920

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   1980

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttga   2040

aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg aactagttat   2100

ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc agtcccccaa   2160

aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg   2220

ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga ctaacggttc   2280

taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga atgccaaaat   2340

cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg   2400

ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg aagactttta   2460

tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg gcattccgag   2520

gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa agcccgaaat   2580

gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa aaataaattc   2640

atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca ttcaggtgac   2700

aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac agctaagaga   2760

acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg gttttcctgt   2820

gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg atggcatgcc   2880

cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga gaaggatctt   2940

agactctgcc gagtttatca aattcacggt cattagacca tttccaggac ttgtgattaa   3000

taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat cagctgaacc   3060

aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa gctctcagat   3120

caagcaagaa ccagacccca cgtggtagac ctcttccctc ctaggcttaa agtatcagtg   3180

gttgagaaga gcttttcgga cctgttacta ccccaagctg tgtaatatac ttgtataaca   3240

gaaatacctt ctatacaaac ctttttttct acttttagat agaaatgtct actttttcag   3300

cagttctgtg aattaaagag cagagtgact gtgggtctgg aatggctggt gtacttggga   3360

atgtactatc aggattttac agcaatgctg ggaaatgaca gggaaaatga caggaatgaa   3420

tctcaccaga ttttttatgt actcagcaga gccttgagtt acggtgttta ttttccaatc   3480

aagtgaagat atctcctact tctcctactg gaacatctca gcttctgcag tgaagaaaaa   3540

ttcctgtgat agttcagttc tttagttttt ctatttgaaa aaaaaaaatc atttaaatga   3600

tcctttgttc acggctctcc ttaatgactg agtgaacagt tcctatctgt atatttgact   3660

aaaccttttc ctaagctatc tctcatggtt cctatgtttt tttatcataa ttaaaagcaa   3720

aaccatctgg atcacctaac agtcagaggt cagtatctca gcgtgtgaat tatagaggaa   3780

atacagagag aacctcttcc acttttactt ttcgtccaaa taaaatgcat ggtgtaccag   3840

aagttgaaga tcgggttgag gattggggct agctcgatga cactaaggcc ccaacatcgc   3900

gggacctgct gtggcgcgga ttcttaggaa cgctgttcta gccggccccc tctccagggg   3960

tcgccgtggc cggcattatt tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga   4020

gtgaggaggg gtcagggggc taaggatgca acctctgacg ttctgcgcct tcctaggaga   4080

gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt aaaataccag ctctacaaga   4140

agctaggctc tgtgacggca tagttttcag tagctttatc acaatattca caatggagaa   4200

ttatatgaca tggtagcaga aataggccct tttatgtgtt gcttctattt tacctcaaat   4260

tgtagatata gggtaatcaa taaaatccat ccatgccttt cacacactaa gt           4312


<210>  4381
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  4381

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
            500                 505                 510


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
        515                 520                 525


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
    530                 535                 540


Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu 
545                 550                 555                 560


Lys Asn Leu Asn 



<210>  4382
<211>  5335
<212>  DNA
<213>  Homo sapiens

<400>  4382
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2100

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2160

tttgaaattt gcttagattt gttgacagcg gtttcctgga gtgctgtctt gagaacgatt   2220

ctgaggaggc tcagcaagaa agagtgtttc agttgattgg gtgtgtctgt catggagaag   2280

gaactcaagc tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa   2340

acccggagtt cttgtatgtg gaaggcttgc cagaggggat tcccttccga agccctacct   2400

ggtttggaat tccacgactt gaaaggatcg tccgcgggag taataaaatc aagttcgttg   2460

ttaaaaaacc tgaactagtt atttcctact tgcctcctgg gatggctagt aaaataaaca   2520

ctaaagcttt gcagtccccc aaaagaccac gaagtcctgg gagtaattca aaggttcctg   2580

aaattgaggt caccgtggaa ggccctaata acaacaatcc tcaaacctca gctgttcgaa   2640

ccccgaccca gactaacggt tctaacgttc ccttcaagcc acgagggaga gagttttcct   2700

ttgaggcctg gaatgccaaa atcacggacc taaaacagaa agttgaaaat ctcttcaatg   2760

agaaatgtgg ggaagctctt ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg   2820

agtctttccc ggaagacttt tatgtggaag gcttacctga gggtgtgcca ttccgaagac   2880

catcgacttt tggcattccg aggctggaga agatactcag aaacaaagcc aaaattaagt   2940

tcatcattaa aaagcccgaa atgtttgaga cggcgattaa ggagagcacc tcctctaaga   3000

gccctcccag aaaaataaat tcatcaccca atgttaatac tactgcatca ggtgttgaag   3060

accttaacat cattcaggtg acaattccag atgatgataa tgaaagactc tcgaaagttg   3120

aaaaagctag acagctaaga gaacaagtga atgacctctt tagtcggaaa tttggtgaag   3180

ctattggtat gggttttcct gtgaaagttc cctacaggaa aatcacaatt aaccctggct   3240

gtgtggtggt tgatggcatg cccccggggg tgtccttcaa agcccccagc tacctggaaa   3300

tcagctccat gagaaggatc ttagactctg ccgagtttat caaattcacg gtcattagac   3360

catttccagg acttgtgatt aataaccagc tggttgatca gagtgagtca gaaggccccg   3420

tgatacaaga atcagctgaa ccaagccagt tggaagttcc agccacagaa ggtaaaagga   3480

cctcttccct cctagggtaa atcagcttct gtgtcaggga tgctgtgtgg tgtccatctg   3540

aaccccctgc atacgcgtag ctaatgtgat ctccccactt tcacataaga tggtggccct   3600

gccttcaggg aatgtgggag ccaggtggga gccttcccgg atatttaagc tagaagattc   3660

tacagggaga ttctccttgg atcaatatat gtctctcagt caaagatgta aaagcacttt   3720

tgccttaaaa agaatgttct gtttctaaat agagtcaacg ttgtcctcct cattggaatt   3780

cactatgagt cagaatcatt agactgactt ttttttttcc atagtaatag tattttgcag   3840

agtctcacag agctgcagat cttttgttca tcttgcagag ttaacaagtc tgatcctgtt   3900

agtccagatt tcttaaattt ggccaagtta taataggagc agtagcttga gacccgaagt   3960

caggaaactt tgacaatgga tttttttttt taatccagag acttgtactg gaatttgcct   4020

taccctgtca gctcatggac ttaaggtttc atcccgcttt atgagtgctt ctgaatccaa   4080

gtcattgtta cctgaatttg caaattaagt tgtgatattc gtgactgtta aattcctgta   4140

attagattaa cctctttgct tgcttgtttg ttttctctcc tattttagct taaagtatca   4200

gtggttgaga agagcttttc ggacctgtta ctaccccaag ctgtgtaata tacttgtata   4260

acagaaatac cttctataca aacctttttt tctactttta gatagaaatg tctacttttt   4320

cagcagttct gtgaattaaa gagcagagtg actgtgggtc tggaatggct ggtgtacttg   4380

ggaatgtact atcaggattt tacagcaatg ctgggaaatg acagggaaaa tgacaggaat   4440

gaatctcacc agatttttta tgtactcagc agagccttga gttacggtgt ttattttcca   4500

atcaagtgaa gatatctcct acttctccta ctggaacatc tcagcttctg cagtgaagaa   4560

aaattcctgt gatagttcag ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa   4620

tgatcctttg ttcacggctc tccttaatga ctgagtgaac agttcctatc tgtatatttg   4680

actaaacctt ttcctaagct atctctcatg gttcctatgt ttttttatca taattaaaag   4740

caaaaccatc tggatcacct aacagtcaga ggtcagtatc tcagcgtgtg aattatagag   4800

gaaatacaga gagaacctct tccactttta cttttcgtcc aaataaaatg catggtgtac   4860

cagaagttga agatcgggtt gaggattggg gctagctcga tgacactaag gccccaacat   4920

cgcgggacct gctgtggcgc ggattcttag gaacgctgtt ctagccggcc ccctctccag   4980

gggtcgccgt ggccggcatt atttcctagt tcttcttgta accctgaggt gccagcgcgg   5040

ggagtgagga ggggtcaggg ggctaaggat gcaacctctg acgttctgcg ccttcctagg   5100

agagtcttac atgtgttgag atttcacaag caatgcgagt tgtaaaatac cagctctaca   5160

agaagctagg ctctgtgacg gcatagtttt cagtagcttt atcacaatat tcacaatgga   5220

gaattatatg acatggtagc agaaataggc ccttttatgt gttgcttcta ttttacctca   5280

aattgtagat atagggtaat caataaaatc catccatgcc tttcacacac taagt        5335


<210>  4383
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  4383

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala 
            580


<210>  4384
<211>  3863
<212>  DNA
<213>  Homo sapiens

<400>  4384
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1980

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   2040

catatcctgt gtttgaatca aacccggagt tcttgtatgt ggaaggcttg ccagagggga   2100

ttcccttccg aagccctacc tggtttggaa ttccacgact tgaaaggatc gtccgcggga   2160

gtaataaaat caagttcgtt gttaaaaaac ctgaactagt tatttcctac ttgcctcctg   2220

ggatggctag taaaataaac actaaagctt tgcagtcccc caaaagacca cgaagtcctg   2280

ggagtaattc aaaggttcct gaaattgagg tcaccgtgga aggccctaat aacaacaatc   2340

ctcaaacctc agctgttcga accccgaccc agactaacgg ttctaacgtt cccttcaagc   2400

cacgagggag agagttttcc tttgaggcct ggaatgccaa aatcacggac ctaaaacaga   2460

aagttgaaaa tctcttcaat gagaaatgtg gggaagctct tggccttaaa caagctgtga   2520

aggtgccgtt cgcgttattt gagtctttcc cggaagactt ttatgtggaa ggcttacctg   2580

agggtgtgcc attccgaaga ccatcgactt ttggcattcc gaggctggag aagatactca   2640

gaaacaaagc caaaattaag ttcatcatta aaaagcccga aatgtttgag acggcgatta   2700

aggagagcac ctcctctaag agccctccca gaaaaataaa ttcatcaccc aatgttaata   2760

ctactgcatc aggtgttgaa gaccttaaca tcattcaggt gacaattcca gatgatgata   2820

atgaaagact ctcgaaagtt gaaaaagcta gacagctaag agaacaagtg aatgacctct   2880

ttagtcggaa atttggtgaa gctattggta tgggttttcc tgtgaaagtt ccctacagga   2940

aaatcacaat taaccctggc tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca   3000

aagcccccag ctacctggaa atcagctcca tgagaaggat cttagactct gccgagttta   3060

tcaaattcac ggtcattaga ccatttccag gacttgtgat taataaccag ctggttgatc   3120

agagtgagtc agaaggcccc gtgatacaag aatcagctga accaagccag ttggaagttc   3180

cagccacaga agaaataaaa gagactgatg gaagctctca gatcaagcaa gaaccagacc   3240

ccacgtggta gacctcttcc ctcctaggca aaaccatctg gatcacctaa cagtcagagg   3300

tcagtatctc agcgtgtgaa ttatagagga aatacagaga gaacctcttc cacttttact   3360

tttcgtccaa ataaaatgca tggtgtacca gaagttgaag atcgggttga ggattggggc   3420

tagctcgatg acactaaggc cccaacatcg cgggacctgc tgtggcgcgg attcttagga   3480

acgctgttct agccggcccc ctctccaggg gtcgccgtgg ccggcattat ttcctagttc   3540

ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc   3600

aacctctgac gttctgcgcc ttcctaggag agtcttacat gtgttgagat ttcacaagca   3660

atgcgagttg taaaatacca gctctacaag aagctaggct ctgtgacggc atagttttca   3720

gtagctttat cacaatattc acaatggaga attatatgac atggtagcag aaataggccc   3780

ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat agggtaatca ataaaatcca   3840

tccatgcctt tcacacacta agt                                           3863


<210>  4385
<211>  888
<212>  PRT
<213>  Homo sapiens

<400>  4385

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
    450                 455                 460


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
465                 470                 475                 480


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
                485                 490                 495


Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr 
            500                 505                 510


Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys 
        515                 520                 525


Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro 
    530                 535                 540


Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys 
545                 550                 555                 560


Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val 
                565                 570                 575


Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg 
            580                 585                 590


Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly 
        595                 600                 605


Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys 
    610                 615                 620


Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly 
625                 630                 635                 640


Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro 
                645                 650                 655


Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg 
            660                 665                 670


Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys 
        675                 680                 685


Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala 
    690                 695                 700


Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser 
705                 710                 715                 720


Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile 
                725                 730                 735


Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val 
            740                 745                 750


Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg 
        755                 760                 765


Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr 
    770                 775                 780


Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro 
785                 790                 795                 800


Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met 
                805                 810                 815


Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
            820                 825                 830


Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu 
        835                 840                 845


Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu 
    850                 855                 860


Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile 
865                 870                 875                 880


Lys Gln Glu Pro Asp Pro Thr Trp 
                885


<210>  4386
<211>  7845
<212>  DNA
<213>  Homo sapiens

<400>  4386
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   1980

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2040

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2100

atcaaacccg gagttcttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2160

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2220

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2280

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2340

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2400

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2460

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2520

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2580

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2640

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2700

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2760

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2820

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2880

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   2940

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3000

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattaggtaa   3060

gtgagagttt cctgcttagt cacaggagcg aatctggagc tcatgaggct gactcttcta   3120

aaatgcagcc acaggtagtc atcgaatccg gcttcctatg ctgtgcaatc aacaaatcaa   3180

aataacttgt gtcatcatta gaatgtcaga tgtgcttcta cgaactaagc tgactctttt   3240

aattctttgg caaagggttg gcaaactagg actgtttgcc aaattcaggc tgcctcctat   3300

ttttagagtc ttcctgaaac acagctacac ccgtattatc catggctgct ttcctgtcac   3360

agtgagtaag tagctgggac tgagaaggca tggcctccaa agtctaaaat atttactctc   3420

tagcactttg tagaaaaacc ttagctaggc acagtggcta acgcctgtaa tcccagcatt   3480

ttgggaggcc aaggcaggca gatcacctga ggtcaggagt tccagaccag cctggccaac   3540

atggtgaaat cccatctcta caaaaataaa acagttagct gggcatgatg gcgggtgcct   3600

gtaatcccag ctactcggga ggctgaggca ggatagtcgc ttgaacccag gaggtggagg   3660

ttgcaatgag ccaagatcat gccactgcac tccagcctgg acgacagagt gagactccat   3720

cacaagaaaa aaagaacttt gtcaacctct gtcttagggc gccttgtcac aggcttcggg   3780

tcagacggat tcaaccttgc atcagccatt tgttagccag gtcactctgt tctttgtctg   3840

taaatgagat tgatcgttgt tcccactgag agtgtcagct ccttcccgta gagcaggcat   3900

gatgattgta ctcacctctg acaccattgt gagtgccaca ttccttccca cgtccttgtc   3960

actgtaagag atgcccacct gagcaccaac cccaggttat cttccccttt gtcttccagc   4020

cccccagaaa cagctacgac tcaacctacc caatcatttc atcatcagat tgccactgtc   4080

tctagttcag gtctcttggg actggcactc agaaatctca taataaatcc tcttgaggct   4140

tctcatacac tcgtcttctt ccaatcttct ttccctcaaa atctcatatt ttggttccac   4200

ttcacccacc gtcattctcc atatcactcc caggagttag gcaaaaagcc ccttccgttc   4260

ttccgtatgt taaacttaga atcactctgt tccctgctct gcgtttctat tttttgtttt   4320

tcctccattt actagtagct taacactttc taacagtgtt cttattattg atacgtatct   4380

atctcttcca taagcttata aggtcacgga taatacttct cattgtagta cgtaaatgac   4440

gtgggctaga tatgagttga ataaacagtt atacctgtaa attcttacag agtgaaaata   4500

aattgttata ctttacaatt tgtttctctc tttagaccat ttccaggact tgtgattaat   4560

aaccgtgagt attttgtgaa gtgttttgtt tttgtttttt cctggggtct gacgtgtgtg   4620

cgtgtgagtg tgtatacatg cttaacgtat atcacgttac ttcacctatg tcagtaacca   4680

ggccaaatac ttgttttagc cctcagtaaa aacaccaggc acttcctagt tgtaaaatta   4740

ttcaagcttc ttaacttcct atcctcgatg cacttaatca taaaatggta ataatagcac   4800

cgattttggg ggagtcgttc cagtagatgg aaagcatctg gaacaggtgt cagcaagctc   4860

ctgccgacgt gtatgcataa agttttattg aaaccaccat cgtgtccatt tgtttatggc   4920

agaactgaga gatggcagca gcaagtgtgt gcctgcaaaa cctaaaatat ttactaattg   4980

gctctgcaag aaaagagttt gcatccccct aacctagaac agtgtctagc ctctagtatg   5040

tgtttagcct acagtatgtg ctcagcgaat acaatctata tttattactg cttttatgac   5100

tgttataatt actgtgcttg gatttcgtta caaagtaagt cacaatgtgc ctgcttctgt   5160

tagtatttca gcacagtgcc tggcacacat ggggctctca aatattgctg agcgagtgaa   5220

caaatgtcct ttcaattcct taacgttgat gtcattttca atagtatttt gagccaaact   5280

taattttgcg agtgtgtttt gttttcttaa ctttattatt aaaaatgtat aaaagtgagg   5340

ccaggcgtgg tggctcacgc ctgtaatccc agcagtttgg gaggctgagg caggcggatc   5400

agttgaggtt gggagttgga gaccagcccg tccaacatgg tgaaagcctg tctctactaa   5460

aaatacaaaa atcagctggg tgtggtggcg cgtgcctgta atcccagcta ctcaggaggc   5520

tgaggcagga gagttgcttg aatcctagag gtggaggttg cagtgagctg agatcgtgcc   5580

attgcactcc agcctgggca acaagagcaa aactctgtcc caataaataa ataaataaaa   5640

tgttctcttt tgttcctgtt cttgtgcggt agtgtggtat agagttttat ggtaattact   5700

gtgaattagt gattctgagg gacatatcag aactctgagg tttgtttcct tctcatcttg   5760

agggaaacag caaatgtatg ttaaaatgct tttccaaggg aacaacacat ccttacatta   5820

tttaaaccaa tctgcttcat tttcagagct ggttgatcag agtgagtcag aaggccccgt   5880

gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag aaataaaaga   5940

gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga cctcttccct   6000

cctagggtaa atcagcttct gtgtcaggga tgctgtgtgg tgtccatctg aaccccctgc   6060

atacgcgtag ctaatgtgat ctccccactt tcacataaga tggtggccct gccttcaggg   6120

aatgtgggag ccaggtggga gccttcccgg atatttaagc tagaagattc tacagggaga   6180

ttctccttgg atcaatatat gtctctcagt caaagatgta aaagcacttt tgccttaaaa   6240

agaatgttct gtttctaaat agagtcaacg ttgtcctcct cattggaatt cactatgagt   6300

cagaatcatt agactgactt ttttttttcc atagtaatag tattttgcag agtctcacag   6360

agctgcagat cttttgttca tcttgcagag ttaacaagtc tgatcctgtt agtccagatt   6420

tcttaaattt ggccaagtta taataggagc agtagcttga gacccgaagt caggaaactt   6480

tgacaatgga tttttttttt taatccagag acttgtactg gaatttgcct taccctgtca   6540

gctcatggac ttaaggtttc atcccgcttt atgagtgctt ctgaatccaa gtcattgtta   6600

cctgaatttg caaattaagt tgtgatattc gtgactgtta aattcctgta attagattaa   6660

cctctttgct tgcttgtttg ttttctctcc tattttagct taaagtatca gtggttgaga   6720

agagcttttc ggacctgtta ctaccccaag ctgtgtaata tacttgtata acagaaatac   6780

cttctataca aacctttttt tctactttta gatagaaatg tctacttttt cagcagttct   6840

gtgaattaaa gagcagagtg actgtgggtc tggaatggct ggtgtacttg ggaatgtact   6900

atcaggattt tacagcaatg ctgggaaatg acagggaaaa tgacaggaat gaatctcacc   6960

agatttttta tgtactcagc agagccttga gttacggtgt ttattttcca atcaagtgaa   7020

gatatctcct acttctccta ctggaacatc tcagcttctg cagtgaagaa aaattcctgt   7080

gatagttcag ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa tgatcctttg   7140

ttcacggctc tccttaatga ctgagtgaac agttcctatc tgtatatttg actaaacctt   7200

ttcctaagct atctctcatg gttcctatgt ttttttatca taattaaaag caaaaccatc   7260

tggatcacct aacagtcaga ggtcagtatc tcagcgtgtg aattatagag gaaatacaga   7320

gagaacctct tccactttta cttttcgtcc aaataaaatg catggtgtac cagaagttga   7380

agatcgggtt gaggattggg gctagctcga tgacactaag gccccaacat cgcgggacct   7440

gctgtggcgc ggattcttag gaacgctgtt ctagccggcc ccctctccag gggtcgccgt   7500

ggccggcatt atttcctagt tcttcttgta accctgaggt gccagcgcgg ggagtgagga   7560

ggggtcaggg ggctaaggat gcaacctctg acgttctgcg ccttcctagg agagtcttac   7620

atgtgttgag atttcacaag caatgcgagt tgtaaaatac cagctctaca agaagctagg   7680

ctctgtgacg gcatagtttt cagtagcttt atcacaatat tcacaatgga gaattatatg   7740

acatggtagc agaaataggc ccttttatgt gttgcttcta ttttacctca aattgtagat   7800

atagggtaat caataaaatc catccatgcc tttcacacac taagt                   7845


<210>  4387
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  4387

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
                565                 570                 575


Ser Ser Leu Leu Lys Asn Leu Asn 
            580


<210>  4388
<211>  4340
<212>  DNA
<213>  Homo sapiens

<400>  4388
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1860

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1920

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1980

aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc   2040

ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt   2100

tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa   2160

taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg   2220

ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg   2280

ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga gggagagagt   2340

tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct   2400

tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt   2460

tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc   2520

gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa   2580

ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct   2640

ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg   2700

ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga   2760

aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg   2820

gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc   2880

ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc   2940

tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca   3000

ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt gagtcagaag   3060

gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc acagaagaaa   3120

taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg tggtagacct   3180

cttccctcct aggcttaaag tatcagtggt tgagaagagc ttttcggacc tgttactacc   3240

ccaagctgtg taatatactt gtataacaga aataccttct atacaaacct ttttttctac   3300

ttttagatag aaatgtctac tttttcagca gttctgtgaa ttaaagagca gagtgactgt   3360

gggtctggaa tggctggtgt acttgggaat gtactatcag gattttacag caatgctggg   3420

aaatgacagg gaaaatgaca ggaatgaatc tcaccagatt ttttatgtac tcagcagagc   3480

cttgagttac ggtgtttatt ttccaatcaa gtgaagatat ctcctacttc tcctactgga   3540

acatctcagc ttctgcagtg aagaaaaatt cctgtgatag ttcagttctt tagtttttct   3600

atttgaaaaa aaaaaatcat ttaaatgatc ctttgttcac ggctctcctt aatgactgag   3660

tgaacagttc ctatctgtat atttgactaa accttttcct aagctatctc tcatggttcc   3720

tatgtttttt tatcataatt aaaagcaaaa ccatctggat cacctaacag tcagaggtca   3780

gtatctcagc gtgtgaatta tagaggaaat acagagagaa cctcttccac ttttactttt   3840

cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc gggttgagga ttggggctag   3900

ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg   3960

ctgttctagc cggccccctc tccaggggtc gccgtggccg gcattatttc ctagttcttc   4020

ttgtaaccct gaggtgccag cgcggggagt gaggaggggt cagggggcta aggatgcaac   4080

ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg ttgagatttc acaagcaatg   4140

cgagttgtaa aataccagct ctacaagaag ctaggctctg tgacggcata gttttcagta   4200

gctttatcac aatattcaca atggagaatt atatgacatg gtagcagaaa taggcccttt   4260

tatgtgttgc ttctatttta cctcaaattg tagatatagg gtaatcaata aaatccatcc   4320

atgcctttca cacactaagt                                               4340


<210>  4389
<211>  863
<212>  PRT
<213>  Homo sapiens

<400>  4389

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg 
            420                 425                 430


Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe 
        435                 440                 445


Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val 
    450                 455                 460


Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly 
465                 470                 475                 480


Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg 
                485                 490                 495


Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu 
            500                 505                 510


Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr 
        515                 520                 525


Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser 
    530                 535                 540


Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn 
545                 550                 555                 560


Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn 
                565                 570                 575


Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn 
            580                 585                 590


Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu 
        595                 600                 605


Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe 
    610                 615                 620


Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro 
625                 630                 635                 640


Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu 
                645                 650                 655


Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys 
            660                 665                 670


Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser 
        675                 680                 685


Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser 
    690                 695                 700


Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp 
705                 710                 715                 720


Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln 
                725                 730                 735


Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly 
            740                 745                 750


Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys 
        755                 760                 765


Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser 
    770                 775                 780


Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe 
785                 790                 795                 800


Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn 
                805                 810                 815


Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser 
            820                 825                 830


Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu 
        835                 840                 845


Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
    850                 855                 860


<210>  4390
<211>  4168
<212>  DNA
<213>  Homo sapiens

<400>  4390
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   2040

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2100

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2160

atcaaacccg gagttcttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2220

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2280

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2340

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2400

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2460

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2520

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2580

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2640

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2700

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2760

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2820

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2880

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2940

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   3000

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3060

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca   3120

tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg   3180

atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag   3240

actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc   3300

ctaggagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct cctacttctc   3360

ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta   3420

gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg ctctccttaa   3480

tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa gctatctctc   3540

atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca cctaacagtc   3600

agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc tcttccactt   3660

ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg gttgaggatt   3720

ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg cgcggattct   3780

taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc attatttcct   3840

agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca gggggctaag   3900

gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt gagatttcac   3960

aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg acggcatagt   4020

tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt agcagaaata   4080

ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt aatcaataaa   4140

atccatccat gcctttcaca cactaagt                                      4168


<210>  4391
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  4391

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
                565                 570                 575


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly 
            580                 585                 590


Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600


<210>  4392
<211>  5222
<212>  DNA
<213>  Homo sapiens

<400>  4392
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   2040

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2100

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2160

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2220

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2280

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2340

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2400

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2460

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2520

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2580

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2640

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2700

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2760

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2820

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2880

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   2940

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   3000

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3060

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3120

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3180

ttcacggtca ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt   3240

gagtcagaag gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc   3300

acagaagaaa taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg   3360

tggtagacct cttccctcct agggtaaatc agcttctgtg tcagggatgc tgtgtggtgt   3420

ccatctgaac cccctgcata cgcgtagcta atgtgatctc cccactttca cataagatgg   3480

tggccctgcc ttcagggaat gtgggagcca ggtgggagcc ttcccggata tttaagctag   3540

aagattctac agggagattc tccttggatc aatatatgtc tctcagtcaa agatgtaaaa   3600

gcacttttgc cttaaaaaga atgttctgtt tctaaataga gtcaacgttg tcctcctcat   3660

tggaattcac tatgagtcag aatcattaga ctgacttttt tttttccata gtaatagtat   3720

tttgcagagt ctcacagagc tgcagatctt ttgttcatct tgcagagtta acaagtctga   3780

tcctgttagt ccagatttct taaatttggc caagttataa taggagcagt agcttgagac   3840

ccgaagtcag gaaactttga caatggattt ttttttttaa tccagagact tgtactggaa   3900

tttgccttac cctgtcagct catggactta aggtttcatc ccgctttatg agtgcttctg   3960

aatccaagtc attgttacct gaatttgcaa attaagttgt gatattcgtg actgttaaat   4020

tcctgtaatt agattaacct ctttgcttgc ttgtttgttt tctctcctat tttagcttaa   4080

agtatcagtg gttgagaaga gcttttcgga cctgttacta ccccaagctg tgtaatatac   4140

ttgtataaca gaaatacctt ctatacaaac ctttttttct acttttagat agaaatgtct   4200

actttttcag cagttctgtg aattaaagag cagagtgact gtgggtctgg aatggctggt   4260

gtacttggga atgtactatc aggattttac agcaatgctg ggaaatgaca gggaaaatga   4320

caggaatgaa tctcaccaga ttttttatgt actcagcaga gccttgagtt acggtgttta   4380

ttttccaatc aagtgaagat atctcctact tctcctactg gaacatctca gcttctgcag   4440

tgaagaaaaa ttcctgtgat agttcagttc tttagttttt ctatttgaaa aaaaaaaatc   4500

atttaaatga tcctttgttc acggctctcc ttaatgactg agtgaacagt tcctatctgt   4560

atatttgact aaaccttttc ctaagctatc tctcatggtt cctatgtttt tttatcataa   4620

ttaaaagcaa aaccatctgg atcacctaac agtcagaggt cagtatctca gcgtgtgaat   4680

tatagaggaa atacagagag aacctcttcc acttttactt ttcgtccaaa taaaatgcat   4740

ggtgtaccag aagttgaaga tcgggttgag gattggggct agctcgatga cactaaggcc   4800

ccaacatcgc gggacctgct gtggcgcgga ttcttaggaa cgctgttcta gccggccccc   4860

tctccagggg tcgccgtggc cggcattatt tcctagttct tcttgtaacc ctgaggtgcc   4920

agcgcgggga gtgaggaggg gtcagggggc taaggatgca acctctgacg ttctgcgcct   4980

tcctaggaga gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt aaaataccag   5040

ctctacaaga agctaggctc tgtgacggca tagttttcag tagctttatc acaatattca   5100

caatggagaa ttatatgaca tggtagcaga aataggccct tttatgtgtt gcttctattt   5160

tacctcaaat tgtagatata gggtaatcaa taaaatccat ccatgccttt cacacactaa   5220

gt                                                                  5222


<210>  4393
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  4393

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
    450                 455                 460


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
465                 470                 475


<210>  4394
<211>  5119
<212>  DNA
<213>  Homo sapiens

<400>  4394
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   2040

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2100

taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2160

ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2220

ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2280

ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2340

ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2400

atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2460

agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2520

agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2580

tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2640

ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2700

tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2760

ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2820

atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2880

ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2940

tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   3000

ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   3060

tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3120

ttatcaaatt cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg   3180

atcagagtga gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag   3240

ttccagccac agaaggtaaa aggacctctt ccctcctagg gtaaatcagc ttctgtgtca   3300

gggatgctgt gtggtgtcca tctgaacccc ctgcatacgc gtagctaatg tgatctcccc   3360

actttcacat aagatggtgg ccctgccttc agggaatgtg ggagccaggt gggagccttc   3420

ccggatattt aagctagaag attctacagg gagattctcc ttggatcaat atatgtctct   3480

cagtcaaaga tgtaaaagca cttttgcctt aaaaagaatg ttctgtttct aaatagagtc   3540

aacgttgtcc tcctcattgg aattcactat gagtcagaat cattagactg actttttttt   3600

ttccatagta atagtatttt gcagagtctc acagagctgc agatcttttg ttcatcttgc   3660

agagttaaca agtctgatcc tgttagtcca gatttcttaa atttggccaa gttataatag   3720

gagcagtagc ttgagacccg aagtcaggaa actttgacaa tggatttttt tttttaatcc   3780

agagacttgt actggaattt gccttaccct gtcagctcat ggacttaagg tttcatcccg   3840

ctttatgagt gcttctgaat ccaagtcatt gttacctgaa tttgcaaatt aagttgtgat   3900

attcgtgact gttaaattcc tgtaattaga ttaacctctt tgcttgcttg tttgttttct   3960

ctcctatttt agcttaaagt atcagtggtt gagaagagct tttcggacct gttactaccc   4020

caagctgtgt aatatacttg tataacagaa ataccttcta tacaaacctt tttttctact   4080

tttagataga aatgtctact ttttcagcag ttctgtgaat taaagagcag agtgactgtg   4140

ggtctggaat ggctggtgta cttgggaatg tactatcagg attttacagc aatgctggga   4200

aatgacaggg aaaatgacag gaatgaatct caccagattt tttatgtact cagcagagcc   4260

ttgagttacg gtgtttattt tccaatcaag tgaagatatc tcctacttct cctactggaa   4320

catctcagct tctgcagtga agaaaaattc ctgtgatagt tcagttcttt agtttttcta   4380

tttgaaaaaa aaaaatcatt taaatgatcc tttgttcacg gctctcctta atgactgagt   4440

gaacagttcc tatctgtata tttgactaaa ccttttccta agctatctct catggttcct   4500

atgttttttt atcataatta aaagcaaaac catctggatc acctaacagt cagaggtcag   4560

tatctcagcg tgtgaattat agaggaaata cagagagaac ctcttccact tttacttttc   4620

gtccaaataa aatgcatggt gtaccagaag ttgaagatcg ggttgaggat tggggctagc   4680

tcgatgacac taaggcccca acatcgcggg acctgctgtg gcgcggattc ttaggaacgc   4740

tgttctagcc ggccccctct ccaggggtcg ccgtggccgg cattatttcc tagttcttct   4800

tgtaaccctg aggtgccagc gcggggagtg aggaggggtc agggggctaa ggatgcaacc   4860

tctgacgttc tgcgccttcc taggagagtc ttacatgtgt tgagatttca caagcaatgc   4920

gagttgtaaa ataccagctc tacaagaagc taggctctgt gacggcatag ttttcagtag   4980

ctttatcaca atattcacaa tggagaatta tatgacatgg tagcagaaat aggccctttt   5040

atgtgttgct tctattttac ctcaaattgt agatataggg taatcaataa aatccatcca   5100

tgcctttcac acactaagt                                                5119


<210>  4395
<211>  899
<212>  PRT
<213>  Homo sapiens

<400>  4395

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
465                 470                 475                 480


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
                485                 490                 495


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
            500                 505                 510


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
        515                 520                 525


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
    530                 535                 540


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
545                 550                 555                 560


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
                565                 570                 575


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
            580                 585                 590


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
        595                 600                 605


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
    610                 615                 620


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
625                 630                 635                 640


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
                645                 650                 655


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
            660                 665                 670


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
        675                 680                 685


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
    690                 695                 700


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
705                 710                 715                 720


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
                725                 730                 735


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
            740                 745                 750


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
        755                 760                 765


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
    770                 775                 780


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
785                 790                 795                 800


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
                805                 810                 815


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
            820                 825                 830


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
        835                 840                 845


Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu 
    850                 855                 860


Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu 
865                 870                 875                 880


Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Gly Lys Arg Thr Ser Ser 
                885                 890                 895


Leu Leu Gly 



<210>  4396
<211>  7929
<212>  DNA
<213>  Homo sapiens

<400>  4396
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gtcaaagaag attggaatgt cagaattacc aagctacgga   1920

agcaagtgga agagattttt aatttgaaat ttgcttagat ttgttgacag cggtttcctg   1980

gagtgctgtc ttgagaacga ttctgaggag gctcagcaag aaagagtgtt tcagttgatt   2040

gggtgtgtct gtcatggaga aggaactcaa gctcttggac tcaccgaggc agtaaaagta   2100

ccatatcctg tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg   2160

attcccttcc gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg   2220

agtaataaaa tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct   2280

gggatggcta gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct   2340

gggagtaatt caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat   2400

cctcaaacct cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag   2460

ccacgaggga gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag   2520

aaagttgaaa atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg   2580

aaggtgccgt tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct   2640

gagggtgtgc cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc   2700

agaaacaaag ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt   2760

aaggagagca cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat   2820

actactgcat caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat   2880

aatgaaagac tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc   2940

tttagtcgga aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg   3000

aaaatcacaa ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc   3060

aaagccccca gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt   3120

atcaaattca cggtcattag gtaagtgaga gtttcctgct tagtcacagg agcgaatctg   3180

gagctcatga ggctgactct tctaaaatgc agccacaggt agtcatcgaa tccggcttcc   3240

tatgctgtgc aatcaacaaa tcaaaataac ttgtgtcatc attagaatgt cagatgtgct   3300

tctacgaact aagctgactc ttttaattct ttggcaaagg gttggcaaac taggactgtt   3360

tgccaaattc aggctgcctc ctatttttag agtcttcctg aaacacagct acacccgtat   3420

tatccatggc tgctttcctg tcacagtgag taagtagctg ggactgagaa ggcatggcct   3480

ccaaagtcta aaatatttac tctctagcac tttgtagaaa aaccttagct aggcacagtg   3540

gctaacgcct gtaatcccag cattttggga ggccaaggca ggcagatcac ctgaggtcag   3600

gagttccaga ccagcctggc caacatggtg aaatcccatc tctacaaaaa taaaacagtt   3660

agctgggcat gatggcgggt gcctgtaatc ccagctactc gggaggctga ggcaggatag   3720

tcgcttgaac ccaggaggtg gaggttgcaa tgagccaaga tcatgccact gcactccagc   3780

ctggacgaca gagtgagact ccatcacaag aaaaaaagaa ctttgtcaac ctctgtctta   3840

gggcgccttg tcacaggctt cgggtcagac ggattcaacc ttgcatcagc catttgttag   3900

ccaggtcact ctgttctttg tctgtaaatg agattgatcg ttgttcccac tgagagtgtc   3960

agctccttcc cgtagagcag gcatgatgat tgtactcacc tctgacacca ttgtgagtgc   4020

cacattcctt cccacgtcct tgtcactgta agagatgccc acctgagcac caaccccagg   4080

ttatcttccc ctttgtcttc cagcccccca gaaacagcta cgactcaacc tacccaatca   4140

tttcatcatc agattgccac tgtctctagt tcaggtctct tgggactggc actcagaaat   4200

ctcataataa atcctcttga ggcttctcat acactcgtct tcttccaatc ttctttccct   4260

caaaatctca tattttggtt ccacttcacc caccgtcatt ctccatatca ctcccaggag   4320

ttaggcaaaa agccccttcc gttcttccgt atgttaaact tagaatcact ctgttccctg   4380

ctctgcgttt ctattttttg tttttcctcc atttactagt agcttaacac tttctaacag   4440

tgttcttatt attgatacgt atctatctct tccataagct tataaggtca cggataatac   4500

ttctcattgt agtacgtaaa tgacgtgggc tagatatgag ttgaataaac agttatacct   4560

gtaaattctt acagagtgaa aataaattgt tatactttac aatttgtttc tctctttaga   4620

ccatttccag gacttgtgat taataaccgt gagtattttg tgaagtgttt tgtttttgtt   4680

ttttcctggg gtctgacgtg tgtgcgtgtg agtgtgtata catgcttaac gtatatcacg   4740

ttacttcacc tatgtcagta accaggccaa atacttgttt tagccctcag taaaaacacc   4800

aggcacttcc tagttgtaaa attattcaag cttcttaact tcctatcctc gatgcactta   4860

atcataaaat ggtaataata gcaccgattt tgggggagtc gttccagtag atggaaagca   4920

tctggaacag gtgtcagcaa gctcctgccg acgtgtatgc ataaagtttt attgaaacca   4980

ccatcgtgtc catttgttta tggcagaact gagagatggc agcagcaagt gtgtgcctgc   5040

aaaacctaaa atatttacta attggctctg caagaaaaga gtttgcatcc ccctaaccta   5100

gaacagtgtc tagcctctag tatgtgttta gcctacagta tgtgctcagc gaatacaatc   5160

tatatttatt actgctttta tgactgttat aattactgtg cttggatttc gttacaaagt   5220

aagtcacaat gtgcctgctt ctgttagtat ttcagcacag tgcctggcac acatggggct   5280

ctcaaatatt gctgagcgag tgaacaaatg tcctttcaat tccttaacgt tgatgtcatt   5340

ttcaatagta ttttgagcca aacttaattt tgcgagtgtg ttttgttttc ttaactttat   5400

tattaaaaat gtataaaagt gaggccaggc gtggtggctc acgcctgtaa tcccagcagt   5460

ttgggaggct gaggcaggcg gatcagttga ggttgggagt tggagaccag cccgtccaac   5520

atggtgaaag cctgtctcta ctaaaaatac aaaaatcagc tgggtgtggt ggcgcgtgcc   5580

tgtaatccca gctactcagg aggctgaggc aggagagttg cttgaatcct agaggtggag   5640

gttgcagtga gctgagatcg tgccattgca ctccagcctg ggcaacaaga gcaaaactct   5700

gtcccaataa ataaataaat aaaatgttct cttttgttcc tgttcttgtg cggtagtgtg   5760

gtatagagtt ttatggtaat tactgtgaat tagtgattct gagggacata tcagaactct   5820

gaggtttgtt tccttctcat cttgagggaa acagcaaatg tatgttaaaa tgcttttcca   5880

agggaacaac acatccttac attatttaaa ccaatctgct tcattttcag agctggttga   5940

tcagagtgag tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt   6000

tccagccaca gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga   6060

ccccacgtgg tagacctctt ccctcctagg gtaaatcagc ttctgtgtca gggatgctgt   6120

gtggtgtcca tctgaacccc ctgcatacgc gtagctaatg tgatctcccc actttcacat   6180

aagatggtgg ccctgccttc agggaatgtg ggagccaggt gggagccttc ccggatattt   6240

aagctagaag attctacagg gagattctcc ttggatcaat atatgtctct cagtcaaaga   6300

tgtaaaagca cttttgcctt aaaaagaatg ttctgtttct aaatagagtc aacgttgtcc   6360

tcctcattgg aattcactat gagtcagaat cattagactg actttttttt ttccatagta   6420

atagtatttt gcagagtctc acagagctgc agatcttttg ttcatcttgc agagttaaca   6480

agtctgatcc tgttagtcca gatttcttaa atttggccaa gttataatag gagcagtagc   6540

ttgagacccg aagtcaggaa actttgacaa tggatttttt tttttaatcc agagacttgt   6600

actggaattt gccttaccct gtcagctcat ggacttaagg tttcatcccg ctttatgagt   6660

gcttctgaat ccaagtcatt gttacctgaa tttgcaaatt aagttgtgat attcgtgact   6720

gttaaattcc tgtaattaga ttaacctctt tgcttgcttg tttgttttct ctcctatttt   6780

agcttaaagt atcagtggtt gagaagagct tttcggacct gttactaccc caagctgtgt   6840

aatatacttg tataacagaa ataccttcta tacaaacctt tttttctact tttagataga   6900

aatgtctact ttttcagcag ttctgtgaat taaagagcag agtgactgtg ggtctggaat   6960

ggctggtgta cttgggaatg tactatcagg attttacagc aatgctggga aatgacaggg   7020

aaaatgacag gaatgaatct caccagattt tttatgtact cagcagagcc ttgagttacg   7080

gtgtttattt tccaatcaag tgaagatatc tcctacttct cctactggaa catctcagct   7140

tctgcagtga agaaaaattc ctgtgatagt tcagttcttt agtttttcta tttgaaaaaa   7200

aaaaatcatt taaatgatcc tttgttcacg gctctcctta atgactgagt gaacagttcc   7260

tatctgtata tttgactaaa ccttttccta agctatctct catggttcct atgttttttt   7320

atcataatta aaagcaaaac catctggatc acctaacagt cagaggtcag tatctcagcg   7380

tgtgaattat agaggaaata cagagagaac ctcttccact tttacttttc gtccaaataa   7440

aatgcatggt gtaccagaag ttgaagatcg ggttgaggat tggggctagc tcgatgacac   7500

taaggcccca acatcgcggg acctgctgtg gcgcggattc ttaggaacgc tgttctagcc   7560

ggccccctct ccaggggtcg ccgtggccgg cattatttcc tagttcttct tgtaaccctg   7620

aggtgccagc gcggggagtg aggaggggtc agggggctaa ggatgcaacc tctgacgttc   7680

tgcgccttcc taggagagtc ttacatgtgt tgagatttca caagcaatgc gagttgtaaa   7740

ataccagctc tacaagaagc taggctctgt gacggcatag ttttcagtag ctttatcaca   7800

atattcacaa tggagaatta tatgacatgg tagcagaaat aggccctttt atgtgttgct   7860

tctattttac ctcaaattgt agatataggg taatcaataa aatccatcca tgcctttcac   7920

acactaagt                                                           7929


<210>  4397
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  4397

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
                485                 490                 495


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
            500                 505                 510


Phe Asn Leu Lys Phe Ala 
        515


<210>  4398
<211>  3975
<212>  DNA
<213>  Homo sapiens

<400>  4398
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1980

aagagatttt taatttgaaa tttgcttaga tttgttgaca gcggtttcct ggagtgctgt   2040

cttgagaacg attctgagga ggctcagcaa gaaagagtgt ttcagttgat tgggtgtgtc   2100

tgtcatggag aaggaactca agctcttgga ctcaccgagg cagtaaaagt accatatcct   2160

gtgtttgaat caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc   2220

cgaagcccta cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa   2280

atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct   2340

agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat   2400

tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc   2460

tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg   2520

agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa   2580

aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg   2640

ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg   2700

ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa   2760

gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc   2820

acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca   2880

tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga   2940

ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg   3000

aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca   3060

attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt caaagccccc   3120

agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc   3180

acggtcatta gaccatttcc aggacttgtg attaataacc agctggttga tcagagtgag   3240

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   3300

gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga ccccacgtgg   3360

tagacctctt ccctcctagg caaaaccatc tggatcacct aacagtcaga ggtcagtatc   3420

tcagcgtgtg aattatagag gaaatacaga gagaacctct tccactttta cttttcgtcc   3480

aaataaaatg catggtgtac cagaagttga agatcgggtt gaggattggg gctagctcga   3540

tgacactaag gccccaacat cgcgggacct gctgtggcgc ggattcttag gaacgctgtt   3600

ctagccggcc ccctctccag gggtcgccgt ggccggcatt atttcctagt tcttcttgta   3660

accctgaggt gccagcgcgg ggagtgagga ggggtcaggg ggctaaggat gcaacctctg   3720

acgttctgcg ccttcctagg agagtcttac atgtgttgag atttcacaag caatgcgagt   3780

tgtaaaatac cagctctaca agaagctagg ctctgtgacg gcatagtttt cagtagcttt   3840

atcacaatat tcacaatgga gaattatatg acatggtagc agaaataggc ccttttatgt   3900

gttgcttcta ttttacctca aattgtagat atagggtaat caataaaatc catccatgcc   3960

tttcacacac taagt                                                    3975


<210>  4399
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  4399

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
    450                 455                 460


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
465                 470


<210>  4400
<211>  5008
<212>  DNA
<213>  Homo sapiens

<400>  4400
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagctca agctcttgga ctcaccgagg   1980

cagtaaaagt accatatcct gtgtttgaat caaacccgga gttcttgtat gtggaaggct   2040

tgccagaggg gattcccttc cgaagcccta cctggtttgg aattccacga cttgaaagga   2100

tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa acctgaacta gttatttcct   2160

acttgcctcc tgggatggct agtaaaataa acactaaagc tttgcagtcc cccaaaagac   2220

cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta   2280

ataacaacaa tcctcaaacc tcagctgttc gaaccccgac ccagactaac ggttctaacg   2340

ttcccttcaa gccacgaggg agagagtttt cctttgaggc ctggaatgcc aaaatcacgg   2400

acctaaaaca gaaagttgaa aatctcttca atgagaaatg tggggaagct cttggcctta   2460

aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg   2520

aaggcttacc tgagggtgtg ccattccgaa gaccatcgac ttttggcatt ccgaggctgg   2580

agaagatact cagaaacaaa gccaaaatta agttcatcat taaaaagccc gaaatgtttg   2640

agacggcgat taaggagagc acctcctcta agagccctcc cagaaaaata aattcatcac   2700

ccaatgttaa tactactgca tcaggtgttg aagaccttaa catcattcag gtgacaattc   2760

cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta agagaacaag   2820

tgaatgacct ctttagtcgg aaatttggtg aagctattgg tatgggtttt cctgtgaaag   2880

ttccctacag gaaaatcaca attaaccctg gctgtgtggt ggttgatggc atgcccccgg   2940

gggtgtcctt caaagccccc agctacctgg aaatcagctc catgagaagg atcttagact   3000

ctgccgagtt tatcaaattc acggtcatta gaccatttcc aggacttgtg attaataacc   3060

agctggttga tcagagtgag tcagaaggcc ccgtgataca agaatcagct gaaccaagcc   3120

agttggaagt tccagccaca gaaggtaaaa ggacctcttc cctcctaggg taaatcagct   3180

tctgtgtcag ggatgctgtg tggtgtccat ctgaaccccc tgcatacgcg tagctaatgt   3240

gatctcccca ctttcacata agatggtggc cctgccttca gggaatgtgg gagccaggtg   3300

ggagccttcc cggatattta agctagaaga ttctacaggg agattctcct tggatcaata   3360

tatgtctctc agtcaaagat gtaaaagcac ttttgcctta aaaagaatgt tctgtttcta   3420

aatagagtca acgttgtcct cctcattgga attcactatg agtcagaatc attagactga   3480

cttttttttt tccatagtaa tagtattttg cagagtctca cagagctgca gatcttttgt   3540

tcatcttgca gagttaacaa gtctgatcct gttagtccag atttcttaaa tttggccaag   3600

ttataatagg agcagtagct tgagacccga agtcaggaaa ctttgacaat ggattttttt   3660

ttttaatcca gagacttgta ctggaatttg ccttaccctg tcagctcatg gacttaaggt   3720

ttcatcccgc tttatgagtg cttctgaatc caagtcattg ttacctgaat ttgcaaatta   3780

agttgtgata ttcgtgactg ttaaattcct gtaattagat taacctcttt gcttgcttgt   3840

ttgttttctc tcctatttta gcttaaagta tcagtggttg agaagagctt ttcggacctg   3900

ttactacccc aagctgtgta atatacttgt ataacagaaa taccttctat acaaaccttt   3960

ttttctactt ttagatagaa atgtctactt tttcagcagt tctgtgaatt aaagagcaga   4020

gtgactgtgg gtctggaatg gctggtgtac ttgggaatgt actatcagga ttttacagca   4080

atgctgggaa atgacaggga aaatgacagg aatgaatctc accagatttt ttatgtactc   4140

agcagagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct cctacttctc   4200

ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta   4260

gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg ctctccttaa   4320

tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa gctatctctc   4380

atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca cctaacagtc   4440

agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc tcttccactt   4500

ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg gttgaggatt   4560

ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg cgcggattct   4620

taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc attatttcct   4680

agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca gggggctaag   4740

gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt gagatttcac   4800

aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg acggcatagt   4860

tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt agcagaaata   4920

ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt aatcaataaa   4980

atccatccat gcctttcaca cactaagt                                      5008


<210>  4401
<211>  923
<212>  PRT
<213>  Homo sapiens

<400>  4401

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
        515                 520                 525


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
    530                 535                 540


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
545                 550                 555                 560


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
                565                 570                 575


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
            580                 585                 590


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
        595                 600                 605


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
    610                 615                 620


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
625                 630                 635                 640


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
                645                 650                 655


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
            660                 665                 670


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
        675                 680                 685


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
    690                 695                 700


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
705                 710                 715                 720


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
                725                 730                 735


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
            740                 745                 750


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
        755                 760                 765


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
    770                 775                 780


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
785                 790                 795                 800


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
                805                 810                 815


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
            820                 825                 830


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
        835                 840                 845


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
    850                 855                 860


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro 
865                 870                 875                 880


Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly 
                885                 890                 895


Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala 
            900                 905                 910


Thr Glu Gly Lys Arg Thr Ser Ser Leu Leu Gly 
        915                 920


<210>  4402
<211>  3878
<212>  DNA
<213>  Homo sapiens

<400>  4402
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagc tcaagctctt ggactcaccg   2040

aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag   2100

gcttgccaga ggggattccc ttccgaagcc ctacctggtt tggaattcca cgacttgaaa   2160

ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt   2220

cctacttgcc tcctgggatg gctagtaaaa taaacactaa agctttgcag tcccccaaaa   2280

gaccacgaag tcctgggagt aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc   2340

ctaataacaa caatcctcaa acctcagctg ttcgaacccc gacccagact aacggttcta   2400

acgttccctt caagccacga gggagagagt tttcctttga ggcctggaat gccaaaatca   2460

cggacctaaa acagaaagtt gaaaatctct tcaatgagaa atgtggggaa gctcttggcc   2520

ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc tttcccggaa gacttttatg   2580

tggaaggctt acctgagggt gtgccattcc gaagaccatc gacttttggc attccgaggc   2640

tggagaagat actcagaaac aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt   2700

ttgagacggc gattaaggag agcacctcct ctaagagccc tcccagaaaa ataaattcat   2760

cacccaatgt taatactact gcatcaggtg ttgaagacct taacatcatt caggtgacaa   2820

ttccagatga tgataatgaa agactctcga aagttgaaaa agctagacag ctaagagaac   2880

aagtgaatga cctctttagt cggaaatttg gtgaagctat tggtatgggt tttcctgtga   2940

aagttcccta caggaaaatc acaattaacc ctggctgtgt ggtggttgat ggcatgcccc   3000

cgggggtgtc cttcaaagcc cccagctacc tggaaatcag ctccatgaga aggatcttag   3060

actctgccga gtttatcaaa ttcacggtca ttagaccatt tccaggactt gtgattaata   3120

accagctggt tgatcagagt gagtcagaag gccccgtgat acaagaatca gctgaaccaa   3180

gccagttgga agttccagcc acagaagaaa taaaagagac tgatggaagc tctcagatca   3240

agcaagaacc agaccccacg tggtagacct cttccctcct aggcaaaacc atctggatca   3300

cctaacagtc agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc   3360

tcttccactt ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg   3420

gttgaggatt ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg   3480

cgcggattct taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc   3540

attatttcct agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca   3600

gggggctaag gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt   3660

gagatttcac aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg   3720

acggcatagt tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt   3780

agcagaaata ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt   3840

aatcaataaa atccatccat gcctttcaca cactaagt                           3878


<210>  4403
<211>  954
<212>  PRT
<213>  Homo sapiens

<400>  4403

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly 
    530                 535                 540


Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro 
545                 550                 555                 560


Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser 
                565                 570                 575


Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser 
            580                 585                 590


Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr 
        595                 600                 605


Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser 
    610                 615                 620


Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile 
625                 630                 635                 640


Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala 
                645                 650                 655


Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro 
            660                 665                 670


Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp 
        675                 680                 685


Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala 
    690                 695                 700


Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser 
705                 710                 715                 720


Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe 
                725                 730                 735


Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg 
            740                 745                 750


Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu 
        755                 760                 765


Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile 
    770                 775                 780


Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu 
785                 790                 795                 800


Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser 
                805                 810                 815


Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe 
            820                 825                 830


Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val 
        835                 840                 845


Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly 
    850                 855                 860


Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser 
865                 870                 875                 880


Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val 
                885                 890                 895


Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln 
            900                 905                 910


Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln 
        915                 920                 925


Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser 
    930                 935                 940


Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  4404
<211>  7167
<212>  DNA
<213>  Homo sapiens

<400>  4404
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   2040

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   2100

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2160

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2220

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2280

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2340

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2400

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2460

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2520

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2580

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2640

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2700

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2760

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2820

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2880

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2940

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   3000

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   3060

cggtcattag gtaagtgaga gtttcctgct tagtcacagg agcgaatctg gagctcatga   3120

ggctgactct tctaaaatgc agccacaggt agtcatcgaa tccggcttcc tatgctgtgc   3180

aatcaacaaa tcaaaataac ttgtgtcatc attagaatgt cagatgtgct tctacgaact   3240

aagctgactc ttttaattct ttggcaaagg gttggcaaac taggactgtt tgccaaattc   3300

aggctgcctc ctatttttag agtcttcctg aaacacagct acacccgtat tatccatggc   3360

tgctttcctg tcacagtgag taagtagctg ggactgagaa ggcatggcct ccaaagtcta   3420

aaatatttac tctctagcac tttgtagaaa aaccttagct aggcacagtg gctaacgcct   3480

gtaatcccag cattttggga ggccaaggca ggcagatcac ctgaggtcag gagttccaga   3540

ccagcctggc caacatggtg aaatcccatc tctacaaaaa taaaacagtt agctgggcat   3600

gatggcgggt gcctgtaatc ccagctactc gggaggctga ggcaggatag tcgcttgaac   3660

ccaggaggtg gaggttgcaa tgagccaaga tcatgccact gcactccagc ctggacgaca   3720

gagtgagact ccatcacaag aaaaaaagaa ctttgtcaac ctctgtctta gggcgccttg   3780

tcacaggctt cgggtcagac ggattcaacc ttgcatcagc catttgttag ccaggtcact   3840

ctgttctttg tctgtaaatg agattgatcg ttgttcccac tgagagtgtc agctccttcc   3900

cgtagagcag gcatgatgat tgtactcacc tctgacacca ttgtgagtgc cacattcctt   3960

cccacgtcct tgtcactgta agagatgccc acctgagcac caaccccagg ttatcttccc   4020

ctttgtcttc cagcccccca gaaacagcta cgactcaacc tacccaatca tttcatcatc   4080

agattgccac tgtctctagt tcaggtctct tgggactggc actcagaaat ctcataataa   4140

atcctcttga ggcttctcat acactcgtct tcttccaatc ttctttccct caaaatctca   4200

tattttggtt ccacttcacc caccgtcatt ctccatatca ctcccaggag ttaggcaaaa   4260

agccccttcc gttcttccgt atgttaaact tagaatcact ctgttccctg ctctgcgttt   4320

ctattttttg tttttcctcc atttactagt agcttaacac tttctaacag tgttcttatt   4380

attgatacgt atctatctct tccataagct tataaggtca cggataatac ttctcattgt   4440

agtacgtaaa tgacgtgggc tagatatgag ttgaataaac agttatacct gtaaattctt   4500

acagagtgaa aataaattgt tatactttac aatttgtttc tctctttaga ccatttccag   4560

gacttgtgat taataaccgt gagtattttg tgaagtgttt tgtttttgtt ttttcctggg   4620

gtctgacgtg tgtgcgtgtg agtgtgtata catgcttaac gtatatcacg ttacttcacc   4680

tatgtcagta accaggccaa atacttgttt tagccctcag taaaaacacc aggcacttcc   4740

tagttgtaaa attattcaag cttcttaact tcctatcctc gatgcactta atcataaaat   4800

ggtaataata gcaccgattt tgggggagtc gttccagtag atggaaagca tctggaacag   4860

gtgtcagcaa gctcctgccg acgtgtatgc ataaagtttt attgaaacca ccatcgtgtc   4920

catttgttta tggcagaact gagagatggc agcagcaagt gtgtgcctgc aaaacctaaa   4980

atatttacta attggctctg caagaaaaga gtttgcatcc ccctaaccta gaacagtgtc   5040

tagcctctag tatgtgttta gcctacagta tgtgctcagc gaatacaatc tatatttatt   5100

actgctttta tgactgttat aattactgtg cttggatttc gttacaaagt aagtcacaat   5160

gtgcctgctt ctgttagtat ttcagcacag tgcctggcac acatggggct ctcaaatatt   5220

gctgagcgag tgaacaaatg tcctttcaat tccttaacgt tgatgtcatt ttcaatagta   5280

ttttgagcca aacttaattt tgcgagtgtg ttttgttttc ttaactttat tattaaaaat   5340

gtataaaagt gaggccaggc gtggtggctc acgcctgtaa tcccagcagt ttgggaggct   5400

gaggcaggcg gatcagttga ggttgggagt tggagaccag cccgtccaac atggtgaaag   5460

cctgtctcta ctaaaaatac aaaaatcagc tgggtgtggt ggcgcgtgcc tgtaatccca   5520

gctactcagg aggctgaggc aggagagttg cttgaatcct agaggtggag gttgcagtga   5580

gctgagatcg tgccattgca ctccagcctg ggcaacaaga gcaaaactct gtcccaataa   5640

ataaataaat aaaatgttct cttttgttcc tgttcttgtg cggtagtgtg gtatagagtt   5700

ttatggtaat tactgtgaat tagtgattct gagggacata tcagaactct gaggtttgtt   5760

tccttctcat cttgagggaa acagcaaatg tatgttaaaa tgcttttcca agggaacaac   5820

acatccttac attatttaaa ccaatctgct tcattttcag agctggttga tcagagtgag   5880

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   5940

gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga ccccacgtgg   6000

tagacctctt ccctcctagg cttaaagtat cagtggttga gaagagcttt tcggacctgt   6060

tactacccca agctgtgtaa tatacttgta taacagaaat accttctata caaacctttt   6120

tttctacttt tagatagaaa tgtctacttt ttcagcagtt ctgtgaatta aagagcagag   6180

tgactgtggg tctggaatgg ctggtgtact tgggaatgta ctatcaggat tttacagcaa   6240

tgctgggaaa tgacagggaa aatgacagga atgaatctca ccagattttt tatgtactca   6300

gcagagcctt gagttacggt gtttattttc caatcaagtg aagatatctc ctacttctcc   6360

tactggaaca tctcagcttc tgcagtgaag aaaaattcct gtgatagttc agttctttag   6420

tttttctatt tgaaaaaaaa aaatcattta aatgatcctt tgttcacggc tctccttaat   6480

gactgagtga acagttccta tctgtatatt tgactaaacc ttttcctaag ctatctctca   6540

tggttcctat gtttttttat cataattaaa agcaaaacca tctggatcac ctaacagtca   6600

gaggtcagta tctcagcgtg tgaattatag aggaaataca gagagaacct cttccacttt   6660

tacttttcgt ccaaataaaa tgcatggtgt accagaagtt gaagatcggg ttgaggattg   6720

gggctagctc gatgacacta aggccccaac atcgcgggac ctgctgtggc gcggattctt   6780

aggaacgctg ttctagccgg ccccctctcc aggggtcgcc gtggccggca ttatttccta   6840

gttcttcttg taaccctgag gtgccagcgc ggggagtgag gaggggtcag ggggctaagg   6900

atgcaacctc tgacgttctg cgccttccta ggagagtctt acatgtgttg agatttcaca   6960

agcaatgcga gttgtaaaat accagctcta caagaagcta ggctctgtga cggcatagtt   7020

ttcagtagct ttatcacaat attcacaatg gagaattata tgacatggta gcagaaatag   7080

gcccttttat gtgttgcttc tattttacct caaattgtag atatagggta atcaataaaa   7140

tccatccatg cctttcacac actaagt                                       7167


<210>  4405
<211>  829
<212>  PRT
<213>  Homo sapiens

<400>  4405

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
465                 470                 475                 480


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
                485                 490                 495


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
            500                 505                 510


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
        515                 520                 525


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
    530                 535                 540


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
545                 550                 555                 560


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
                565                 570                 575


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
            580                 585                 590


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
        595                 600                 605


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
    610                 615                 620


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
625                 630                 635                 640


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
                645                 650                 655


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
            660                 665                 670


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
        675                 680                 685


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
    690                 695                 700


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
705                 710                 715                 720


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
                725                 730                 735


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
            740                 745                 750


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
        755                 760                 765


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
    770                 775                 780


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
785                 790                 795                 800


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
                805                 810                 815


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
            820                 825


<210>  4406
<211>  4055
<212>  DNA
<213>  Homo sapiens

<400>  4406
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agctcaagct cttggactca ccgaggcagt aaaagtacca tatcctgtgt   1920

ttgaatcaaa cccggagttc ttgtatgtgg aaggcttgcc agaggggatt cccttccgaa   1980

gccctacctg gtttggaatt ccacgacttg aaaggatcgt ccgcgggagt aataaaatca   2040

agttcgttgt taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta   2100

aaataaacac taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa   2160

aggttcctga aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag   2220

ctgttcgaac cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag   2280

agttttcctt tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc   2340

tcttcaatga gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg   2400

cgttatttga gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat   2460

tccgaagacc atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca   2520

aaattaagtt catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct   2580

cctctaagag ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag   2640

gtgttgaaga ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct   2700

cgaaagttga aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat   2760

ttggtgaagc tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta   2820

accctggctg tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct   2880

acctggaaat cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg   2940

tcattagacc atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag   3000

aaggccccgt gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag   3060

aaataaaaga gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga   3120

cctcttccct cctaggctta aagtatcagt ggttgagaag agcttttcgg acctgttact   3180

accccaagct gtagccttga gttacggtgt ttattttcca atcaagtgaa gatatctcct   3240

acttctccta ctggaacatc tcagcttctg cagtgaagaa aaattcctgt gatagttcag   3300

ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa tgatcctttg ttcacggctc   3360

tccttaatga ctgagtgaac agttcctatc tgtatatttg actaaacctt ttcctaagct   3420

atctctcatg gttcctatgt ttttttatca taattaaaag caaaaccatc tggatcacct   3480

aacagtcaga ggtcagtatc tcagcgtgtg aattatagag gaaatacaga gagaacctct   3540

tccactttta cttttcgtcc aaataaaatg catggtgtac cagaagttga agatcgggtt   3600

gaggattggg gctagctcga tgacactaag gccccaacat cgcgggacct gctgtggcgc   3660

ggattcttag gaacgctgtt ctagccggcc ccctctccag gggtcgccgt ggccggcatt   3720

atttcctagt tcttcttgta accctgaggt gccagcgcgg ggagtgagga ggggtcaggg   3780

ggctaaggat gcaacctctg acgttctgcg ccttcctagg agagtcttac atgtgttgag   3840

atttcacaag caatgcgagt tgtaaaatac cagctctaca agaagctagg ctctgtgacg   3900

gcatagtttt cagtagcttt atcacaatat tcacaatgga gaattatatg acatggtagc   3960

agaaataggc ccttttatgt gttgcttcta ttttacctca aattgtagat atagggtaat   4020

caataaaatc catccatgcc tttcacacac taagt                              4055


<210>  4407
<211>  844
<212>  PRT
<213>  Homo sapiens

<400>  4407

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala 
            420                 425                 430


Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser 
        435                 440                 445


Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
    450                 455                 460


Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg 
465                 470                 475                 480


Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile 
                485                 490                 495


Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu 
            500                 505                 510


Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro 
        515                 520                 525


Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr 
    530                 535                 540


Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe 
545                 550                 555                 560


Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile 
                565                 570                 575


Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly 
            580                 585                 590


Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe 
        595                 600                 605


Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val 
    610                 615                 620


Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile 
625                 630                 635                 640


Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met 
                645                 650                 655


Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg 
            660                 665                 670


Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu 
        675                 680                 685


Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg 
    690                 695                 700


Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp 
705                 710                 715                 720


Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val 
                725                 730                 735


Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val 
            740                 745                 750


Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu 
        755                 760                 765


Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe 
    770                 775                 780


Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val 
785                 790                 795                 800


Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro 
                805                 810                 815


Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly 
            820                 825                 830


Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
        835                 840


<210>  4408
<211>  4354
<212>  DNA
<213>  Homo sapiens

<400>  4408
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2100

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2160

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2220

tgaatcaaac ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag   2280

ccctacctgg tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa   2340

gttcgttgtt aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa   2400

aataaacact aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa   2460

ggttcctgaa attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc   2520

tgttcgaacc ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga   2580

gttttccttt gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct   2640

cttcaatgag aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc   2700

gttatttgag tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt   2760

ccgaagacca tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa   2820

aattaagttc atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc   2880

ctctaagagc cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg   2940

tgttgaagac cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc   3000

gaaagttgaa aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt   3060

tggtgaagct attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa   3120

ccctggctgt gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta   3180

cctggaaatc agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt   3240

cattagacca tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga   3300

aggccccgtg atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga   3360

aataaaagag actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac   3420

ctcttccctc ctaggcttaa agtatcagtg gttgagaaga gcttttcgga cctgttacta   3480

ccccaagctg tagccttgag ttacggtgtt tattttccaa tcaagtgaag atatctccta   3540

cttctcctac tggaacatct cagcttctgc agtgaagaaa aattcctgtg atagttcagt   3600

tctttagttt ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt tcacggctct   3660

ccttaatgac tgagtgaaca gttcctatct gtatatttga ctaaaccttt tcctaagcta   3720

tctctcatgg ttcctatgtt tttttatcat aattaaaagc aaaaccatct ggatcaccta   3780

acagtcagag gtcagtatct cagcgtgtga attatagagg aaatacagag agaacctctt   3840

ccacttttac ttttcgtcca aataaaatgc atggtgtacc agaagttgaa gatcgggttg   3900

aggattgggg ctagctcgat gacactaagg ccccaacatc gcgggacctg ctgtggcgcg   3960

gattcttagg aacgctgttc tagccggccc cctctccagg ggtcgccgtg gccggcatta   4020

tttcctagtt cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg   4080

gctaaggatg caacctctga cgttctgcgc cttcctagga gagtcttaca tgtgttgaga   4140

tttcacaagc aatgcgagtt gtaaaatacc agctctacaa gaagctaggc tctgtgacgg   4200

catagttttc agtagcttta tcacaatatt cacaatggag aattatatga catggtagca   4260

gaaataggcc cttttatgtg ttgcttctat tttacctcaa attgtagata tagggtaatc   4320

aataaaatcc atccatgcct ttcacacact aagt                               4354


<210>  4409
<211>  998
<212>  PRT
<213>  Homo sapiens

<400>  4409

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr 
        595                 600                 605


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe 
    610                 615                 620


Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys 
625                 630                 635                 640


Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly 
                645                 650                 655


Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro 
            660                 665                 670


Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val 
        675                 680                 685


Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro 
    690                 695                 700


Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu 
705                 710                 715                 720


Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys 
                725                 730                 735


Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys 
            740                 745                 750


Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp 
        755                 760                 765


Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser 
    770                 775                 780


Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys 
785                 790                 795                 800


Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys 
                805                 810                 815


Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro 
            820                 825                 830


Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln 
        835                 840                 845


Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys 
    850                 855                 860


Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe 
865                 870                 875                 880


Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys 
                885                 890                 895


Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly 
            900                 905                 910


Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg 
        915                 920                 925


Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe 
    930                 935                 940


Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu 
945                 950                 955                 960


Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro 
                965                 970                 975


Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln 
            980                 985                 990


Glu Pro Asp Pro Thr Trp 
        995


<210>  4410
<211>  3840
<212>  DNA
<213>  Homo sapiens

<400>  4410
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   1980

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2040

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2100

atcaaacccg gagttcttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2160

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2220

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2280

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2340

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2400

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2460

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2520

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2580

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2640

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2700

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2760

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2820

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2880

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   2940

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3000

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca   3060

tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg   3120

atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag   3180

actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc   3240

ctaggcaaaa ccatctggat cacctaacag tcagaggtca gtatctcagc gtgtgaatta   3300

tagaggaaat acagagagaa cctcttccac ttttactttt cgtccaaata aaatgcatgg   3360

tgtaccagaa gttgaagatc gggttgagga ttggggctag ctcgatgaca ctaaggcccc   3420

aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg ctgttctagc cggccccctc   3480

tccaggggtc gccgtggccg gcattatttc ctagttcttc ttgtaaccct gaggtgccag   3540

cgcggggagt gaggaggggt cagggggcta aggatgcaac ctctgacgtt ctgcgccttc   3600

ctaggagagt cttacatgtg ttgagatttc acaagcaatg cgagttgtaa aataccagct   3660

ctacaagaag ctaggctctg tgacggcata gttttcagta gctttatcac aatattcaca   3720

atggagaatt atatgacatg gtagcagaaa taggcccttt tatgtgttgc ttctatttta   3780

cctcaaattg tagatatagg gtaatcaata aaatccatcc atgcctttca cacactaagt   3840


<210>  4411
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  4411

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
                565                 570                 575


Ser Ser Leu Leu Lys Asn Leu Asn 
            580


<210>  4412
<211>  3866
<212>  DNA
<213>  Homo sapiens

<400>  4412
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040

taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2100

ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2160

ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2220

ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2280

ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2340

atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2400

agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2460

agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2520

tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2580

ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2640

tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2700

ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2760

atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2820

ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2880

tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   2940

ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   3000

tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3060

ttatcaaatt cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg   3120

atcagagtga gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag   3180

ttccagccac agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag   3240

accccacgtg gtagacctct tccctcctag gcaaaaccat ctggatcacc taacagtcag   3300

aggtcagtat ctcagcgtgt gaattataga ggaaatacag agagaacctc ttccactttt   3360

acttttcgtc caaataaaat gcatggtgta ccagaagttg aagatcgggt tgaggattgg   3420

ggctagctcg atgacactaa ggccccaaca tcgcgggacc tgctgtggcg cggattctta   3480

ggaacgctgt tctagccggc cccctctcca ggggtcgccg tggccggcat tatttcctag   3540

ttcttcttgt aaccctgagg tgccagcgcg gggagtgagg aggggtcagg gggctaagga   3600

tgcaacctct gacgttctgc gccttcctag gagagtctta catgtgttga gatttcacaa   3660

gcaatgcgag ttgtaaaata ccagctctac aagaagctag gctctgtgac ggcatagttt   3720

tcagtagctt tatcacaata ttcacaatgg agaattatat gacatggtag cagaaatagg   3780

cccttttatg tgttgcttct attttacctc aaattgtaga tatagggtaa tcaataaaat   3840

ccatccatgc ctttcacaca ctaagt                                        3866


<210>  4413
<211>  889
<212>  PRT
<213>  Homo sapiens

<400>  4413

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
    450                 455                 460


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
465                 470                 475                 480


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
                485                 490                 495


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
            500                 505                 510


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
        515                 520                 525


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
    530                 535                 540


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
545                 550                 555                 560


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
                565                 570                 575


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
            580                 585                 590


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
        595                 600                 605


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
    610                 615                 620


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
625                 630                 635                 640


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
                645                 650                 655


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
            660                 665                 670


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
        675                 680                 685


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
    690                 695                 700


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
705                 710                 715                 720


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
                725                 730                 735


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
            740                 745                 750


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
        755                 760                 765


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
    770                 775                 780


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
785                 790                 795                 800


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
                805                 810                 815


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
            820                 825                 830


Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser 
        835                 840                 845


Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu 
    850                 855                 860


Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln 
865                 870                 875                 880


Ile Lys Gln Glu Pro Asp Pro Thr Trp 
                885


<210>  4414
<211>  5071
<212>  DNA
<213>  Homo sapiens

<400>  4414
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1920

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   1980

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttgt   2040

atgtggaagg cttgccagag gggattccct tccgaagccc tacctggttt ggaattccac   2100

gacttgaaag gatcgtccgc gggagtaata aaatcaagtt cgttgttaaa aaacctgaac   2160

tagttatttc ctacttgcct cctgggatgg ctagtaaaat aaacactaaa gctttgcagt   2220

cccccaaaag accacgaagt cctgggagta attcaaaggt tcctgaaatt gaggtcaccg   2280

tggaaggccc taataacaac aatcctcaaa cctcagctgt tcgaaccccg acccagacta   2340

acggttctaa cgttcccttc aagccacgag ggagagagtt ttcctttgag gcctggaatg   2400

ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt caatgagaaa tgtggggaag   2460

ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt atttgagtct ttcccggaag   2520

acttttatgt ggaaggctta cctgagggtg tgccattccg aagaccatcg acttttggca   2580

ttccgaggct ggagaagata ctcagaaaca aagccaaaat taagttcatc attaaaaagc   2640

ccgaaatgtt tgagacggcg attaaggaga gcacctcctc taagagccct cccagaaaaa   2700

taaattcatc acccaatgtt aatactactg catcaggtgt tgaagacctt aacatcattc   2760

aggtgacaat tccagatgat gataatgaaa gactctcgaa agttgaaaaa gctagacagc   2820

taagagaaca agtgaatgac ctctttagtc ggaaatttgg tgaagctatt ggtatgggtt   2880

ttcctgtgaa agttccctac aggaaaatca caattaaccc tggctgtgtg gtggttgatg   2940

gcatgccccc gggggtgtcc ttcaaagccc ccagctacct ggaaatcagc tccatgagaa   3000

ggatcttaga ctctgccgag tttatcaaat tcacggtcat tagaccattt ccaggacttg   3060

tgattaataa ccagctggtt gatcagagtg agtcagaagg ccccgtgata caagaatcag   3120

ctgaaccaag ccagttggaa gttccagcca cagaagaaat aaaagagact gatggaagct   3180

ctcagatcaa gcaagaacca gaccccacgt ggtagacctc ttccctccta gggtaaatca   3240

gcttctgtgt cagggatgct gtgtggtgtc catctgaacc ccctgcatac gcgtagctaa   3300

tgtgatctcc ccactttcac ataagatggt ggccctgcct tcagggaatg tgggagccag   3360

gtgggagcct tcccggatat ttaagctaga agattctaca gggagattct ccttggatca   3420

atatatgtct ctcagtcaaa gatgtaaaag cacttttgcc ttaaaaagaa tgttctgttt   3480

ctaaatagag tcaacgttgt cctcctcatt ggaattcact atgagtcaga atcattagac   3540

tgactttttt ttttccatag taatagtatt ttgcagagtc tcacagagct gcagatcttt   3600

tgttcatctt gcagagttaa caagtctgat cctgttagtc cagatttctt aaatttggcc   3660

aagttataat aggagcagta gcttgagacc cgaagtcagg aaactttgac aatggatttt   3720

tttttttaat ccagagactt gtactggaat ttgccttacc ctgtcagctc atggacttaa   3780

ggtttcatcc cgctttatga gtgcttctga atccaagtca ttgttacctg aatttgcaaa   3840

ttaagttgtg atattcgtga ctgttaaatt cctgtaatta gattaacctc tttgcttgct   3900

tgtttgtttt ctctcctatt ttagcttaaa gtatcagtgg ttgagaagag cttttcggac   3960

ctgttactac cccaagctgt gtaatatact tgtataacag aaataccttc tatacaaacc   4020

tttttttcta cttttagata gaaatgtcta ctttttcagc agttctgtga attaaagagc   4080

agagtgactg tgggtctgga atggctggtg tacttgggaa tgtactatca ggattttaca   4140

gcaatgctgg gaaatgacag ggaaaatgac aggaatgaat ctcaccagat tttttatgta   4200

ctcagcagag ccttgagtta cggtgtttat tttccaatca agtgaagata tctcctactt   4260

ctcctactgg aacatctcag cttctgcagt gaagaaaaat tcctgtgata gttcagttct   4320

ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat cctttgttca cggctctcct   4380

taatgactga gtgaacagtt cctatctgta tatttgacta aaccttttcc taagctatct   4440

ctcatggttc ctatgttttt ttatcataat taaaagcaaa accatctgga tcacctaaca   4500

gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa tacagagaga acctcttcca   4560

cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga agttgaagat cgggttgagg   4620

attggggcta gctcgatgac actaaggccc caacatcgcg ggacctgctg tggcgcggat   4680

tcttaggaac gctgttctag ccggccccct ctccaggggt cgccgtggcc ggcattattt   4740

cctagttctt cttgtaaccc tgaggtgcca gcgcggggag tgaggagggg tcagggggct   4800

aaggatgcaa cctctgacgt tctgcgcctt cctaggagag tcttacatgt gttgagattt   4860

cacaagcaat gcgagttgta aaataccagc tctacaagaa gctaggctct gtgacggcat   4920

agttttcagt agctttatca caatattcac aatggagaat tatatgacat ggtagcagaa   4980

ataggccctt ttatgtgttg cttctatttt acctcaaatt gtagatatag ggtaatcaat   5040

aaaatccatc catgcctttc acacactaag t                                  5071


<210>  4415
<211>  937
<212>  PRT
<213>  Homo sapiens

<400>  4415

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
            500                 505                 510


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
        515                 520                 525


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
    530                 535                 540


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
545                 550                 555                 560


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
                565                 570                 575


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
            580                 585                 590


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
        595                 600                 605


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
    610                 615                 620


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
625                 630                 635                 640


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
                645                 650                 655


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
            660                 665                 670


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
        675                 680                 685


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
    690                 695                 700


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
705                 710                 715                 720


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
                725                 730                 735


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
            740                 745                 750


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
        755                 760                 765


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
    770                 775                 780


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
785                 790                 795                 800


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
                805                 810                 815


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
            820                 825                 830


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
        835                 840                 845


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
    850                 855                 860


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
865                 870                 875                 880


Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser 
                885                 890                 895


Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu 
            900                 905                 910


Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln 
        915                 920                 925


Ile Lys Gln Glu Pro Asp Pro Thr Trp 
    930                 935


<210>  4416
<211>  7983
<212>  DNA
<213>  Homo sapiens

<400>  4416
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   2040

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2100

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2160

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2220

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2280

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2340

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2400

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2460

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2520

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2580

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2640

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2700

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2760

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2820

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2880

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   2940

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   3000

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3060

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3120

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3180

ttcacggtca ttaggtaagt gagagtttcc tgcttagtca caggagcgaa tctggagctc   3240

atgaggctga ctcttctaaa atgcagccac aggtagtcat cgaatccggc ttcctatgct   3300

gtgcaatcaa caaatcaaaa taacttgtgt catcattaga atgtcagatg tgcttctacg   3360

aactaagctg actcttttaa ttctttggca aagggttggc aaactaggac tgtttgccaa   3420

attcaggctg cctcctattt ttagagtctt cctgaaacac agctacaccc gtattatcca   3480

tggctgcttt cctgtcacag tgagtaagta gctgggactg agaaggcatg gcctccaaag   3540

tctaaaatat ttactctcta gcactttgta gaaaaacctt agctaggcac agtggctaac   3600

gcctgtaatc ccagcatttt gggaggccaa ggcaggcaga tcacctgagg tcaggagttc   3660

cagaccagcc tggccaacat ggtgaaatcc catctctaca aaaataaaac agttagctgg   3720

gcatgatggc gggtgcctgt aatcccagct actcgggagg ctgaggcagg atagtcgctt   3780

gaacccagga ggtggaggtt gcaatgagcc aagatcatgc cactgcactc cagcctggac   3840

gacagagtga gactccatca caagaaaaaa agaactttgt caacctctgt cttagggcgc   3900

cttgtcacag gcttcgggtc agacggattc aaccttgcat cagccatttg ttagccaggt   3960

cactctgttc tttgtctgta aatgagattg atcgttgttc ccactgagag tgtcagctcc   4020

ttcccgtaga gcaggcatga tgattgtact cacctctgac accattgtga gtgccacatt   4080

ccttcccacg tccttgtcac tgtaagagat gcccacctga gcaccaaccc caggttatct   4140

tcccctttgt cttccagccc cccagaaaca gctacgactc aacctaccca atcatttcat   4200

catcagattg ccactgtctc tagttcaggt ctcttgggac tggcactcag aaatctcata   4260

ataaatcctc ttgaggcttc tcatacactc gtcttcttcc aatcttcttt ccctcaaaat   4320

ctcatatttt ggttccactt cacccaccgt cattctccat atcactccca ggagttaggc   4380

aaaaagcccc ttccgttctt ccgtatgtta aacttagaat cactctgttc cctgctctgc   4440

gtttctattt tttgtttttc ctccatttac tagtagctta acactttcta acagtgttct   4500

tattattgat acgtatctat ctcttccata agcttataag gtcacggata atacttctca   4560

ttgtagtacg taaatgacgt gggctagata tgagttgaat aaacagttat acctgtaaat   4620

tcttacagag tgaaaataaa ttgttatact ttacaatttg tttctctctt tagaccattt   4680

ccaggacttg tgattaataa ccgtgagtat tttgtgaagt gttttgtttt tgttttttcc   4740

tggggtctga cgtgtgtgcg tgtgagtgtg tatacatgct taacgtatat cacgttactt   4800

cacctatgtc agtaaccagg ccaaatactt gttttagccc tcagtaaaaa caccaggcac   4860

ttcctagttg taaaattatt caagcttctt aacttcctat cctcgatgca cttaatcata   4920

aaatggtaat aatagcaccg attttggggg agtcgttcca gtagatggaa agcatctgga   4980

acaggtgtca gcaagctcct gccgacgtgt atgcataaag ttttattgaa accaccatcg   5040

tgtccatttg tttatggcag aactgagaga tggcagcagc aagtgtgtgc ctgcaaaacc   5100

taaaatattt actaattggc tctgcaagaa aagagtttgc atccccctaa cctagaacag   5160

tgtctagcct ctagtatgtg tttagcctac agtatgtgct cagcgaatac aatctatatt   5220

tattactgct tttatgactg ttataattac tgtgcttgga tttcgttaca aagtaagtca   5280

caatgtgcct gcttctgtta gtatttcagc acagtgcctg gcacacatgg ggctctcaaa   5340

tattgctgag cgagtgaaca aatgtccttt caattcctta acgttgatgt cattttcaat   5400

agtattttga gccaaactta attttgcgag tgtgttttgt tttcttaact ttattattaa   5460

aaatgtataa aagtgaggcc aggcgtggtg gctcacgcct gtaatcccag cagtttggga   5520

ggctgaggca ggcggatcag ttgaggttgg gagttggaga ccagcccgtc caacatggtg   5580

aaagcctgtc tctactaaaa atacaaaaat cagctgggtg tggtggcgcg tgcctgtaat   5640

cccagctact caggaggctg aggcaggaga gttgcttgaa tcctagaggt ggaggttgca   5700

gtgagctgag atcgtgccat tgcactccag cctgggcaac aagagcaaaa ctctgtccca   5760

ataaataaat aaataaaatg ttctcttttg ttcctgttct tgtgcggtag tgtggtatag   5820

agttttatgg taattactgt gaattagtga ttctgaggga catatcagaa ctctgaggtt   5880

tgtttccttc tcatcttgag ggaaacagca aatgtatgtt aaaatgcttt tccaagggaa   5940

caacacatcc ttacattatt taaaccaatc tgcttcattt tcagagctgg ttgatcagag   6000

tgagtcagaa ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc   6060

cacagaagaa ataaaagaga ctgatggaag ctctcagatc aagcaagaac cagaccccac   6120

gtggtagacc tcttccctcc tagggtaaat cagcttctgt gtcagggatg ctgtgtggtg   6180

tccatctgaa ccccctgcat acgcgtagct aatgtgatct ccccactttc acataagatg   6240

gtggccctgc cttcagggaa tgtgggagcc aggtgggagc cttcccggat atttaagcta   6300

gaagattcta cagggagatt ctccttggat caatatatgt ctctcagtca aagatgtaaa   6360

agcacttttg ccttaaaaag aatgttctgt ttctaaatag agtcaacgtt gtcctcctca   6420

ttggaattca ctatgagtca gaatcattag actgactttt ttttttccat agtaatagta   6480

ttttgcagag tctcacagag ctgcagatct tttgttcatc ttgcagagtt aacaagtctg   6540

atcctgttag tccagatttc ttaaatttgg ccaagttata ataggagcag tagcttgaga   6600

cccgaagtca ggaaactttg acaatggatt ttttttttta atccagagac ttgtactgga   6660

atttgcctta ccctgtcagc tcatggactt aaggtttcat cccgctttat gagtgcttct   6720

gaatccaagt cattgttacc tgaatttgca aattaagttg tgatattcgt gactgttaaa   6780

ttcctgtaat tagattaacc tctttgcttg cttgtttgtt ttctctccta ttttagctta   6840

aagtatcagt ggttgagaag agcttttcgg acctgttact accccaagct gtgtaatata   6900

cttgtataac agaaatacct tctatacaaa cctttttttc tacttttaga tagaaatgtc   6960

tactttttca gcagttctgt gaattaaaga gcagagtgac tgtgggtctg gaatggctgg   7020

tgtacttggg aatgtactat caggatttta cagcaatgct gggaaatgac agggaaaatg   7080

acaggaatga atctcaccag attttttatg tactcagcag agccttgagt tacggtgttt   7140

attttccaat caagtgaaga tatctcctac ttctcctact ggaacatctc agcttctgca   7200

gtgaagaaaa attcctgtga tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat   7260

catttaaatg atcctttgtt cacggctctc cttaatgact gagtgaacag ttcctatctg   7320

tatatttgac taaacctttt cctaagctat ctctcatggt tcctatgttt ttttatcata   7380

attaaaagca aaaccatctg gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa   7440

ttatagagga aatacagaga gaacctcttc cacttttact tttcgtccaa ataaaatgca   7500

tggtgtacca gaagttgaag atcgggttga ggattggggc tagctcgatg acactaaggc   7560

cccaacatcg cgggacctgc tgtggcgcgg attcttagga acgctgttct agccggcccc   7620

ctctccaggg gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac cctgaggtgc   7680

cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc   7740

ttcctaggag agtcttacat gtgttgagat ttcacaagca atgcgagttg taaaatacca   7800

gctctacaag aagctaggct ctgtgacggc atagttttca gtagctttat cacaatattc   7860

acaatggaga attatatgac atggtagcag aaataggccc ttttatgtgt tgcttctatt   7920

ttacctcaaa ttgtagatat agggtaatca ataaaatcca tccatgcctt tcacacacta   7980

agt                                                                 7983


<210>  4417
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  4417

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
    450                 455                 460


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
465                 470                 475


<210>  4418
<211>  3900
<212>  DNA
<213>  Homo sapiens

<400>  4418
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   2040

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2100

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2160

atcaaacccg gagttcttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2220

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2280

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2340

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2400

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2460

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2520

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2580

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2640

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2700

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2760

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2820

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2880

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2940

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   3000

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3060

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca   3120

tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg   3180

atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag   3240

actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc   3300

ctaggcaaaa ccatctggat cacctaacag tcagaggtca gtatctcagc gtgtgaatta   3360

tagaggaaat acagagagaa cctcttccac ttttactttt cgtccaaata aaatgcatgg   3420

tgtaccagaa gttgaagatc gggttgagga ttggggctag ctcgatgaca ctaaggcccc   3480

aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg ctgttctagc cggccccctc   3540

tccaggggtc gccgtggccg gcattatttc ctagttcttc ttgtaaccct gaggtgccag   3600

cgcggggagt gaggaggggt cagggggcta aggatgcaac ctctgacgtt ctgcgccttc   3660

ctaggagagt cttacatgtg ttgagatttc acaagcaatg cgagttgtaa aataccagct   3720

ctacaagaag ctaggctctg tgacggcata gttttcagta gctttatcac aatattcaca   3780

atggagaatt atatgacatg gtagcagaaa taggcccttt tatgtgttgc ttctatttta   3840

cctcaaattg tagatatagg gtaatcaata aaatccatcc atgcctttca cacactaagt   3900


<210>  4419
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  4419

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
                565                 570                 575


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly 
            580                 585                 590


Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600


<210>  4420
<211>  4151
<212>  DNA
<213>  Homo sapiens

<400>  4420
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   2040

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2100

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2160

tgaaaggatc gtccgcggga gtaataaaat caagttcgtt gttaaaaaac ctgaactagt   2220

tatttcctac ttgcctcctg ggatggctag taaaataaac actaaagctt tgcagtcccc   2280

caaaagacca cgaagtcctg ggagtaattc aaaggttcct gaaattgagg tcaccgtgga   2340

aggccctaat aacaacaatc ctcaaacctc agctgttcga accccgaccc agactaacgg   2400

ttctaacgtt cccttcaagc cacgagggag agagttttcc tttgaggcct ggaatgccaa   2460

aatcacggac ctaaaacaga aagttgaaaa tctcttcaat gagaaatgtg gggaagctct   2520

tggccttaaa caagctgtga aggtgccgtt cgcgttattt gagtctttcc cggaagactt   2580

ttatgtggaa ggcttacctg agggtgtgcc attccgaaga ccatcgactt ttggcattcc   2640

gaggctggag aagatactca gaaacaaagc caaaattaag ttcatcatta aaaagcccga   2700

aatgtttgag acggcgatta aggagagcac ctcctctaag agccctccca gaaaaataaa   2760

ttcatcaccc aatgttaata ctactgcatc aggtgttgaa gaccttaaca tcattcaggt   2820

gacaattcca gatgatgata atgaaagact ctcgaaagtt gaaaaagcta gacagctaag   2880

agaacaagtg aatgacctct ttagtcggaa atttggtgaa gctattggta tgggttttcc   2940

tgtgaaagtt ccctacagga aaatcacaat taaccctggc tgtgtggtgg ttgatggcat   3000

gcccccgggg gtgtccttca aagcccccag ctacctggaa atcagctcca tgagaaggat   3060

cttagactct gccgagttta tcaaattcac ggtcattaga ccatttccag gacttgtgat   3120

taataaccag ctggttgatc agagtgagtc agaaggcccc gtgatacaag aatcagctga   3180

accaagccag ttggaagttc cagccacaga agaaataaaa gagactgatg gaagctctca   3240

gatcaagcaa gaaccagacc ccacgtggta gacctcttcc ctcctaggag ccttgagtta   3300

cggtgtttat tttccaatca agtgaagata tctcctactt ctcctactgg aacatctcag   3360

cttctgcagt gaagaaaaat tcctgtgata gttcagttct ttagtttttc tatttgaaaa   3420

aaaaaaatca tttaaatgat cctttgttca cggctctcct taatgactga gtgaacagtt   3480

cctatctgta tatttgacta aaccttttcc taagctatct ctcatggttc ctatgttttt   3540

ttatcataat taaaagcaaa accatctgga tcacctaaca gtcagaggtc agtatctcag   3600

cgtgtgaatt atagaggaaa tacagagaga acctcttcca cttttacttt tcgtccaaat   3660

aaaatgcatg gtgtaccaga agttgaagat cgggttgagg attggggcta gctcgatgac   3720

actaaggccc caacatcgcg ggacctgctg tggcgcggat tcttaggaac gctgttctag   3780

ccggccccct ctccaggggt cgccgtggcc ggcattattt cctagttctt cttgtaaccc   3840

tgaggtgcca gcgcggggag tgaggagggg tcagggggct aaggatgcaa cctctgacgt   3900

tctgcgcctt cctaggagag tcttacatgt gttgagattt cacaagcaat gcgagttgta   3960

aaataccagc tctacaagaa gctaggctct gtgacggcat agttttcagt agctttatca   4020

caatattcac aatggagaat tatatgacat ggtagcagaa ataggccctt ttatgtgttg   4080

cttctatttt acctcaaatt gtagatatag ggtaatcaat aaaatccatc catgcctttc   4140

acacactaag t                                                        4151


<210>  4421
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  4421

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala 
            580                 585                 590


Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600                 605


<210>  4422
<211>  4151
<212>  DNA
<213>  Homo sapiens

<400>  4422
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1920

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   1980

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttgt   2040

atgtggaagg cttgccagag gggattccct tccgaagccc tacctggttt ggaattccac   2100

gacttgaaag gatcgtccgc gggagtaata aaatcaagtt cgttgttaaa aaacctgaac   2160

tagttatttc ctacttgcct cctgggatgg ctagtaaaat aaacactaaa gctttgcagt   2220

cccccaaaag accacgaagt cctgggagta attcaaaggt tcctgaaatt gaggtcaccg   2280

tggaaggccc taataacaac aatcctcaaa cctcagctgt tcgaaccccg acccagacta   2340

acggttctaa cgttcccttc aagccacgag ggagagagtt ttcctttgag gcctggaatg   2400

ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt caatgagaaa tgtggggaag   2460

ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt atttgagtct ttcccggaag   2520

acttttatgt ggaaggctta cctgagggtg tgccattccg aagaccatcg acttttggca   2580

ttccgaggct ggagaagata ctcagaaaca aagccaaaat taagttcatc attaaaaagc   2640

ccgaaatgtt tgagacggcg attaaggaga gcacctcctc taagagccct cccagaaaaa   2700

taaattcatc acccaatgtt aatactactg catcaggtgt tgaagacctt aacatcattc   2760

aggtgacaat tccagatgat gataatgaaa gactctcgaa agttgaaaaa gctagacagc   2820

taagagaaca agtgaatgac ctctttagtc ggaaatttgg tgaagctatt ggtatgggtt   2880

ttcctgtgaa agttccctac aggaaaatca caattaaccc tggctgtgtg gtggttgatg   2940

gcatgccccc gggggtgtcc ttcaaagccc ccagctacct ggaaatcagc tccatgagaa   3000

ggatcttaga ctctgccgag tttatcaaat tcacggtcat tagaccattt ccaggacttg   3060

tgattaataa ccagctggtt gatcagagtg agtcagaagg ccccgtgata caagaatcag   3120

ctgaaccaag ccagttggaa gttccagcca cagaagaaat aaaagagact gatggaagct   3180

ctcagatcaa gcaagaacca gaccccacgt ggtagacctc ttccctccta ggcttaaagt   3240

atcagtggtt gagaagagct tttcggacct gttactaccc caagctgtag ccttgagtta   3300

cggtgtttat tttccaatca agtgaagata tctcctactt ctcctactgg aacatctcag   3360

cttctgcagt gaagaaaaat tcctgtgata gttcagttct ttagtttttc tatttgaaaa   3420

aaaaaaatca tttaaatgat cctttgttca cggctctcct taatgactga gtgaacagtt   3480

cctatctgta tatttgacta aaccttttcc taagctatct ctcatggttc ctatgttttt   3540

ttatcataat taaaagcaaa accatctgga tcacctaaca gtcagaggtc agtatctcag   3600

cgtgtgaatt atagaggaaa tacagagaga acctcttcca cttttacttt tcgtccaaat   3660

aaaatgcatg gtgtaccaga agttgaagat cgggttgagg attggggcta gctcgatgac   3720

actaaggccc caacatcgcg ggacctgctg tggcgcggat tcttaggaac gctgttctag   3780

ccggccccct ctccaggggt cgccgtggcc ggcattattt cctagttctt cttgtaaccc   3840

tgaggtgcca gcgcggggag tgaggagggg tcagggggct aaggatgcaa cctctgacgt   3900

tctgcgcctt cctaggagag tcttacatgt gttgagattt cacaagcaat gcgagttgta   3960

aaataccagc tctacaagaa gctaggctct gtgacggcat agttttcagt agctttatca   4020

caatattcac aatggagaat tatatgacat ggtagcagaa ataggccctt ttatgtgttg   4080

cttctatttt acctcaaatt gtagatatag ggtaatcaat aaaatccatc catgcctttc   4140

acacactaag t                                                        4151


<210>  4423
<211>  937
<212>  PRT
<213>  Homo sapiens

<400>  4423

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
            500                 505                 510


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
        515                 520                 525


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
    530                 535                 540


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
545                 550                 555                 560


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
                565                 570                 575


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
            580                 585                 590


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
        595                 600                 605


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
    610                 615                 620


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
625                 630                 635                 640


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
                645                 650                 655


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
            660                 665                 670


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
        675                 680                 685


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
    690                 695                 700


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
705                 710                 715                 720


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
                725                 730                 735


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
            740                 745                 750


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
        755                 760                 765


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
    770                 775                 780


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
785                 790                 795                 800


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
                805                 810                 815


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
            820                 825                 830


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
        835                 840                 845


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
    850                 855                 860


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
865                 870                 875                 880


Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser 
                885                 890                 895


Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu 
            900                 905                 910


Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln 
        915                 920                 925


Ile Lys Gln Glu Pro Asp Pro Thr Trp 
    930                 935


<210>  4424
<211>  4013
<212>  DNA
<213>  Homo sapiens

<400>  4424
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gtcaaagaag attggaatgt cagaattacc aagctacgga   1920

agcaagtgga agagattttt aatttgaaat ttgctcaagc tcttggactc accgaggcag   1980

taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgaaagga tcgtccgcgg   2040

gagtaataaa atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc   2100

tgggatggct agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc   2160

tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa   2220

tcctcaaacc tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa   2280

gccacgaggg agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca   2340

gaaagttgaa aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt   2400

gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc   2460

tgagggtgtg ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact   2520

cagaaacaaa gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat   2580

taaggagagc acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa   2640

tactactgca tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga   2700

taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct   2760

ctttagtcgg aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag   2820

gaaaatcaca attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt   2880

caaagccccc agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt   2940

tatcaaattc acggtcatta gaccatttcc aggacttgtg attaataacc agctggttga   3000

tcagagtgag tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt   3060

tccagccaca gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga   3120

ccccacgtgg tagacctctt ccctcctagg agccttgagt tacggtgttt attttccaat   3180

caagtgaaga tatctcctac ttctcctact ggaacatctc agcttctgca gtgaagaaaa   3240

attcctgtga tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat catttaaatg   3300

atcctttgtt cacggctctc cttaatgact gagtgaacag ttcctatctg tatatttgac   3360

taaacctttt cctaagctat ctctcatggt tcctatgttt ttttatcata attaaaagca   3420

aaaccatctg gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa ttatagagga   3480

aatacagaga gaacctcttc cacttttact tttcgtccaa ataaaatgca tggtgtacca   3540

gaagttgaag atcgggttga ggattggggc tagctcgatg acactaaggc cccaacatcg   3600

cgggacctgc tgtggcgcgg attcttagga acgctgttct agccggcccc ctctccaggg   3660

gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg   3720

agtgaggagg ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc ttcctaggag   3780

agtcttacat gtgttgagat ttcacaagca atgcgagttg taaaatacca gctctacaag   3840

aagctaggct ctgtgacggc atagttttca gtagctttat cacaatattc acaatggaga   3900

attatatgac atggtagcag aaataggccc ttttatgtgt tgcttctatt ttacctcaaa   3960

ttgtagatat agggtaatca ataaaatcca tccatgcctt tcacacacta agt          4013


<210>  4425
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  4425

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
                485                 490                 495


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
            500                 505                 510


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
        515                 520                 525


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser 
    530                 535                 540


Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
545                 550                 555


<210>  4426
<211>  7859
<212>  DNA
<213>  Homo sapiens

<400>  4426
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   2040

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   2100

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2160

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2220

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2280

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2340

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2400

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2460

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2520

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2580

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2640

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2700

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2760

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2820

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2880

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2940

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   3000

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   3060

cggtcattag gtaagtgaga gtttcctgct tagtcacagg agcgaatctg gagctcatga   3120

ggctgactct tctaaaatgc agccacaggt agtcatcgaa tccggcttcc tatgctgtgc   3180

aatcaacaaa tcaaaataac ttgtgtcatc attagaatgt cagatgtgct tctacgaact   3240

aagctgactc ttttaattct ttggcaaagg gttggcaaac taggactgtt tgccaaattc   3300

aggctgcctc ctatttttag agtcttcctg aaacacagct acacccgtat tatccatggc   3360

tgctttcctg tcacagtgag taagtagctg ggactgagaa ggcatggcct ccaaagtcta   3420

aaatatttac tctctagcac tttgtagaaa aaccttagct aggcacagtg gctaacgcct   3480

gtaatcccag cattttggga ggccaaggca ggcagatcac ctgaggtcag gagttccaga   3540

ccagcctggc caacatggtg aaatcccatc tctacaaaaa taaaacagtt agctgggcat   3600

gatggcgggt gcctgtaatc ccagctactc gggaggctga ggcaggatag tcgcttgaac   3660

ccaggaggtg gaggttgcaa tgagccaaga tcatgccact gcactccagc ctggacgaca   3720

gagtgagact ccatcacaag aaaaaaagaa ctttgtcaac ctctgtctta gggcgccttg   3780

tcacaggctt cgggtcagac ggattcaacc ttgcatcagc catttgttag ccaggtcact   3840

ctgttctttg tctgtaaatg agattgatcg ttgttcccac tgagagtgtc agctccttcc   3900

cgtagagcag gcatgatgat tgtactcacc tctgacacca ttgtgagtgc cacattcctt   3960

cccacgtcct tgtcactgta agagatgccc acctgagcac caaccccagg ttatcttccc   4020

ctttgtcttc cagcccccca gaaacagcta cgactcaacc tacccaatca tttcatcatc   4080

agattgccac tgtctctagt tcaggtctct tgggactggc actcagaaat ctcataataa   4140

atcctcttga ggcttctcat acactcgtct tcttccaatc ttctttccct caaaatctca   4200

tattttggtt ccacttcacc caccgtcatt ctccatatca ctcccaggag ttaggcaaaa   4260

agccccttcc gttcttccgt atgttaaact tagaatcact ctgttccctg ctctgcgttt   4320

ctattttttg tttttcctcc atttactagt agcttaacac tttctaacag tgttcttatt   4380

attgatacgt atctatctct tccataagct tataaggtca cggataatac ttctcattgt   4440

agtacgtaaa tgacgtgggc tagatatgag ttgaataaac agttatacct gtaaattctt   4500

acagagtgaa aataaattgt tatactttac aatttgtttc tctctttaga ccatttccag   4560

gacttgtgat taataaccgt gagtattttg tgaagtgttt tgtttttgtt ttttcctggg   4620

gtctgacgtg tgtgcgtgtg agtgtgtata catgcttaac gtatatcacg ttacttcacc   4680

tatgtcagta accaggccaa atacttgttt tagccctcag taaaaacacc aggcacttcc   4740

tagttgtaaa attattcaag cttcttaact tcctatcctc gatgcactta atcataaaat   4800

ggtaataata gcaccgattt tgggggagtc gttccagtag atggaaagca tctggaacag   4860

gtgtcagcaa gctcctgccg acgtgtatgc ataaagtttt attgaaacca ccatcgtgtc   4920

catttgttta tggcagaact gagagatggc agcagcaagt gtgtgcctgc aaaacctaaa   4980

atatttacta attggctctg caagaaaaga gtttgcatcc ccctaaccta gaacagtgtc   5040

tagcctctag tatgtgttta gcctacagta tgtgctcagc gaatacaatc tatatttatt   5100

actgctttta tgactgttat aattactgtg cttggatttc gttacaaagt aagtcacaat   5160

gtgcctgctt ctgttagtat ttcagcacag tgcctggcac acatggggct ctcaaatatt   5220

gctgagcgag tgaacaaatg tcctttcaat tccttaacgt tgatgtcatt ttcaatagta   5280

ttttgagcca aacttaattt tgcgagtgtg ttttgttttc ttaactttat tattaaaaat   5340

gtataaaagt gaggccaggc gtggtggctc acgcctgtaa tcccagcagt ttgggaggct   5400

gaggcaggcg gatcagttga ggttgggagt tggagaccag cccgtccaac atggtgaaag   5460

cctgtctcta ctaaaaatac aaaaatcagc tgggtgtggt ggcgcgtgcc tgtaatccca   5520

gctactcagg aggctgaggc aggagagttg cttgaatcct agaggtggag gttgcagtga   5580

gctgagatcg tgccattgca ctccagcctg ggcaacaaga gcaaaactct gtcccaataa   5640

ataaataaat aaaatgttct cttttgttcc tgttcttgtg cggtagtgtg gtatagagtt   5700

ttatggtaat tactgtgaat tagtgattct gagggacata tcagaactct gaggtttgtt   5760

tccttctcat cttgagggaa acagcaaatg tatgttaaaa tgcttttcca agggaacaac   5820

acatccttac attatttaaa ccaatctgct tcattttcag agctggttga tcagagtgag   5880

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   5940

gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga ccccacgtgg   6000

tagacctctt ccctcctagg gtaaatcagc ttctgtgtca gggatgctgt gtggtgtcca   6060

tctgaacccc ctgcatacgc gtagctaatg tgatctcccc actttcacat aagatggtgg   6120

ccctgccttc agggaatgtg ggagccaggt gggagccttc ccggatattt aagctagaag   6180

attctacagg gagattctcc ttggatcaat atatgtctct cagtcaaaga tgtaaaagca   6240

cttttgcctt aaaaagaatg ttctgtttct aaatagagtc aacgttgtcc tcctcattgg   6300

aattcactat gagtcagaat cattagactg actttttttt ttccatagta atagtatttt   6360

gcagagtctc acagagctgc agatcttttg ttcatcttgc agagttaaca agtctgatcc   6420

tgttagtcca gatttcttaa atttggccaa gttataatag gagcagtagc ttgagacccg   6480

aagtcaggaa actttgacaa tggatttttt tttttaatcc agagacttgt actggaattt   6540

gccttaccct gtcagctcat ggacttaagg tttcatcccg ctttatgagt gcttctgaat   6600

ccaagtcatt gttacctgaa tttgcaaatt aagttgtgat attcgtgact gttaaattcc   6660

tgtaattaga ttaacctctt tgcttgcttg tttgttttct ctcctatttt agcttaaagt   6720

atcagtggtt gagaagagct tttcggacct gttactaccc caagctgtgt aatatacttg   6780

tataacagaa ataccttcta tacaaacctt tttttctact tttagataga aatgtctact   6840

ttttcagcag ttctgtgaat taaagagcag agtgactgtg ggtctggaat ggctggtgta   6900

cttgggaatg tactatcagg attttacagc aatgctggga aatgacaggg aaaatgacag   6960

gaatgaatct caccagattt tttatgtact cagcagagcc ttgagttacg gtgtttattt   7020

tccaatcaag tgaagatatc tcctacttct cctactggaa catctcagct tctgcagtga   7080

agaaaaattc ctgtgatagt tcagttcttt agtttttcta tttgaaaaaa aaaaatcatt   7140

taaatgatcc tttgttcacg gctctcctta atgactgagt gaacagttcc tatctgtata   7200

tttgactaaa ccttttccta agctatctct catggttcct atgttttttt atcataatta   7260

aaagcaaaac catctggatc acctaacagt cagaggtcag tatctcagcg tgtgaattat   7320

agaggaaata cagagagaac ctcttccact tttacttttc gtccaaataa aatgcatggt   7380

gtaccagaag ttgaagatcg ggttgaggat tggggctagc tcgatgacac taaggcccca   7440

acatcgcggg acctgctgtg gcgcggattc ttaggaacgc tgttctagcc ggccccctct   7500

ccaggggtcg ccgtggccgg cattatttcc tagttcttct tgtaaccctg aggtgccagc   7560

gcggggagtg aggaggggtc agggggctaa ggatgcaacc tctgacgttc tgcgccttcc   7620

taggagagtc ttacatgtgt tgagatttca caagcaatgc gagttgtaaa ataccagctc   7680

tacaagaagc taggctctgt gacggcatag ttttcagtag ctttatcaca atattcacaa   7740

tggagaatta tatgacatgg tagcagaaat aggccctttt atgtgttgct tctattttac   7800

ctcaaattgt agatataggg taatcaataa aatccatcca tgcctttcac acactaagt    7859


<210>  4427
<211>  829
<212>  PRT
<213>  Homo sapiens

<400>  4427

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
465                 470                 475                 480


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
                485                 490                 495


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
            500                 505                 510


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
        515                 520                 525


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
    530                 535                 540


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
545                 550                 555                 560


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
                565                 570                 575


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
            580                 585                 590


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
        595                 600                 605


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
    610                 615                 620


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
625                 630                 635                 640


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
                645                 650                 655


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
            660                 665                 670


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
        675                 680                 685


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
    690                 695                 700


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
705                 710                 715                 720


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
                725                 730                 735


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
            740                 745                 750


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
        755                 760                 765


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
    770                 775                 780


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
785                 790                 795                 800


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
                805                 810                 815


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
            820                 825


<210>  4428
<211>  5084
<212>  DNA
<213>  Homo sapiens

<400>  4428
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   1980

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2040

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2100

atcaaacccg gagttcttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2160

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2220

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2280

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2340

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2400

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2460

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2520

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2580

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2640

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2700

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2760

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2820

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2880

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   2940

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3000

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca   3060

tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg   3120

atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag   3180

actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc   3240

ctagggtaaa tcagcttctg tgtcagggat gctgtgtggt gtccatctga accccctgca   3300

tacgcgtagc taatgtgatc tccccacttt cacataagat ggtggccctg ccttcaggga   3360

atgtgggagc caggtgggag ccttcccgga tatttaagct agaagattct acagggagat   3420

tctccttgga tcaatatatg tctctcagtc aaagatgtaa aagcactttt gccttaaaaa   3480

gaatgttctg tttctaaata gagtcaacgt tgtcctcctc attggaattc actatgagtc   3540

agaatcatta gactgacttt tttttttcca tagtaatagt attttgcaga gtctcacaga   3600

gctgcagatc ttttgttcat cttgcagagt taacaagtct gatcctgtta gtccagattt   3660

cttaaatttg gccaagttat aataggagca gtagcttgag acccgaagtc aggaaacttt   3720

gacaatggat tttttttttt aatccagaga cttgtactgg aatttgcctt accctgtcag   3780

ctcatggact taaggtttca tcccgcttta tgagtgcttc tgaatccaag tcattgttac   3840

ctgaatttgc aaattaagtt gtgatattcg tgactgttaa attcctgtaa ttagattaac   3900

ctctttgctt gcttgtttgt tttctctcct attttagctt aaagtatcag tggttgagaa   3960

gagcttttcg gacctgttac taccccaagc tgtgtaatat acttgtataa cagaaatacc   4020

ttctatacaa accttttttt ctacttttag atagaaatgt ctactttttc agcagttctg   4080

tgaattaaag agcagagtga ctgtgggtct ggaatggctg gtgtacttgg gaatgtacta   4140

tcaggatttt acagcaatgc tgggaaatga cagggaaaat gacaggaatg aatctcacca   4200

gattttttat gtactcagca gagccttgag ttacggtgtt tattttccaa tcaagtgaag   4260

atatctccta cttctcctac tggaacatct cagcttctgc agtgaagaaa aattcctgtg   4320

atagttcagt tctttagttt ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt   4380

tcacggctct ccttaatgac tgagtgaaca gttcctatct gtatatttga ctaaaccttt   4440

tcctaagcta tctctcatgg ttcctatgtt tttttatcat aattaaaagc aaaaccatct   4500

ggatcaccta acagtcagag gtcagtatct cagcgtgtga attatagagg aaatacagag   4560

agaacctctt ccacttttac ttttcgtcca aataaaatgc atggtgtacc agaagttgaa   4620

gatcgggttg aggattgggg ctagctcgat gacactaagg ccccaacatc gcgggacctg   4680

ctgtggcgcg gattcttagg aacgctgttc tagccggccc cctctccagg ggtcgccgtg   4740

gccggcatta tttcctagtt cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag   4800

gggtcagggg gctaaggatg caacctctga cgttctgcgc cttcctagga gagtcttaca   4860

tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc agctctacaa gaagctaggc   4920

tctgtgacgg catagttttc agtagcttta tcacaatatt cacaatggag aattatatga   4980

catggtagca gaaataggcc cttttatgtg ttgcttctat tttacctcaa attgtagata   5040

tagggtaatc aataaaatcc atccatgcct ttcacacact aagt                    5084


<210>  4429
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  4429

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
                565                 570                 575


Ser Ser Leu Leu Lys Asn Leu Asn 
            580


<210>  4430
<211>  4088
<212>  DNA
<213>  Homo sapiens

<400>  4430
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gctcaagctc ttggactcac   1980

cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct tgtatgtgga   2040

aggcttgcca gaggggattc ccttccgaag ccctacctgg tttggaattc cacgacttga   2100

aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg aactagttat   2160

ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc agtcccccaa   2220

aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg   2280

ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga ctaacggttc   2340

taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga atgccaaaat   2400

cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg   2460

ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg aagactttta   2520

tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg gcattccgag   2580

gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa agcccgaaat   2640

gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa aaataaattc   2700

atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca ttcaggtgac   2760

aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac agctaagaga   2820

acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg gttttcctgt   2880

gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg atggcatgcc   2940

cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga gaaggatctt   3000

agactctgcc gagtttatca aattcacggt cattagacca tttccaggac ttgtgattaa   3060

taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat cagctgaacc   3120

aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa gctctcagat   3180

caagcaagaa ccagacccca cgtggtagac ctcttccctc ctaggagcct tgagttacgg   3240

tgtttatttt ccaatcaagt gaagatatct cctacttctc ctactggaac atctcagctt   3300

ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa   3360

aaaatcattt aaatgatcct ttgttcacgg ctctccttaa tgactgagtg aacagttcct   3420

atctgtatat ttgactaaac cttttcctaa gctatctctc atggttccta tgttttttta   3480

tcataattaa aagcaaaacc atctggatca cctaacagtc agaggtcagt atctcagcgt   3540

gtgaattata gaggaaatac agagagaacc tcttccactt ttacttttcg tccaaataaa   3600

atgcatggtg taccagaagt tgaagatcgg gttgaggatt ggggctagct cgatgacact   3660

aaggccccaa catcgcggga cctgctgtgg cgcggattct taggaacgct gttctagccg   3720

gccccctctc caggggtcgc cgtggccggc attatttcct agttcttctt gtaaccctga   3780

ggtgccagcg cggggagtga ggaggggtca gggggctaag gatgcaacct ctgacgttct   3840

gcgccttcct aggagagtct tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa   3900

taccagctct acaagaagct aggctctgtg acggcatagt tttcagtagc tttatcacaa   3960

tattcacaat ggagaattat atgacatggt agcagaaata ggccctttta tgtgttgctt   4020

ctattttacc tcaaattgta gatatagggt aatcaataaa atccatccat gcctttcaca   4080

cactaagt                                                            4088


<210>  4431
<211>  928
<212>  PRT
<213>  Homo sapiens

<400>  4431

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro 
        515                 520                 525


Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu 
    530                 535                 540


Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu 
545                 550                 555                 560


Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro 
                565                 570                 575


Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn 
            580                 585                 590


Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn 
        595                 600                 605


Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn 
    610                 615                 620


Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser 
625                 630                 635                 640


Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp 
                645                 650                 655


Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn 
            660                 665                 670


Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro 
        675                 680                 685


Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu 
    690                 695                 700


Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg 
705                 710                 715                 720


Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys 
                725                 730                 735


Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys 
            740                 745                 750


Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala 
        755                 760                 765


Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp 
    770                 775                 780


Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu 
785                 790                 795                 800


Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met 
                805                 810                 815


Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly 
            820                 825                 830


Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro 
        835                 840                 845


Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu 
    850                 855                 860


Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn 
865                 870                 875                 880


Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu 
                885                 890                 895


Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys 
            900                 905                 910


Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
        915                 920                 925


<210>  4432
<211>  7897
<212>  DNA
<213>  Homo sapiens

<400>  4432
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gtcaaagaag attggaatgt   1980

cagaattacc aagctacgga agcaagtgga agagattttt aatttgaaat ttgctcaagc   2040

tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt   2100

cttgtatgtg gaaggcttgc cagaggggat tcccttccga agccctacct ggtttggaat   2160

tccacgactt gaaaggatcg tccgcgggag taataaaatc aagttcgttg ttaaaaaacc   2220

tgaactagtt atttcctact tgcctcctgg gatggctagt aaaataaaca ctaaagcttt   2280

gcagtccccc aaaagaccac gaagtcctgg gagtaattca aaggttcctg aaattgaggt   2340

caccgtggaa ggccctaata acaacaatcc tcaaacctca gctgttcgaa ccccgaccca   2400

gactaacggt tctaacgttc ccttcaagcc acgagggaga gagttttcct ttgaggcctg   2460

gaatgccaaa atcacggacc taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg   2520

ggaagctctt ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg agtctttccc   2580

ggaagacttt tatgtggaag gcttacctga gggtgtgcca ttccgaagac catcgacttt   2640

tggcattccg aggctggaga agatactcag aaacaaagcc aaaattaagt tcatcattaa   2700

aaagcccgaa atgtttgaga cggcgattaa ggagagcacc tcctctaaga gccctcccag   2760

aaaaataaat tcatcaccca atgttaatac tactgcatca ggtgttgaag accttaacat   2820

cattcaggtg acaattccag atgatgataa tgaaagactc tcgaaagttg aaaaagctag   2880

acagctaaga gaacaagtga atgacctctt tagtcggaaa tttggtgaag ctattggtat   2940

gggttttcct gtgaaagttc cctacaggaa aatcacaatt aaccctggct gtgtggtggt   3000

tgatggcatg cccccggggg tgtccttcaa agcccccagc tacctggaaa tcagctccat   3060

gagaaggatc ttagactctg ccgagtttat caaattcacg gtcattaggt aagtgagagt   3120

ttcctgctta gtcacaggag cgaatctgga gctcatgagg ctgactcttc taaaatgcag   3180

ccacaggtag tcatcgaatc cggcttccta tgctgtgcaa tcaacaaatc aaaataactt   3240

gtgtcatcat tagaatgtca gatgtgcttc tacgaactaa gctgactctt ttaattcttt   3300

ggcaaagggt tggcaaacta ggactgtttg ccaaattcag gctgcctcct atttttagag   3360

tcttcctgaa acacagctac acccgtatta tccatggctg ctttcctgtc acagtgagta   3420

agtagctggg actgagaagg catggcctcc aaagtctaaa atatttactc tctagcactt   3480

tgtagaaaaa ccttagctag gcacagtggc taacgcctgt aatcccagca ttttgggagg   3540

ccaaggcagg cagatcacct gaggtcagga gttccagacc agcctggcca acatggtgaa   3600

atcccatctc tacaaaaata aaacagttag ctgggcatga tggcgggtgc ctgtaatccc   3660

agctactcgg gaggctgagg caggatagtc gcttgaaccc aggaggtgga ggttgcaatg   3720

agccaagatc atgccactgc actccagcct ggacgacaga gtgagactcc atcacaagaa   3780

aaaaagaact ttgtcaacct ctgtcttagg gcgccttgtc acaggcttcg ggtcagacgg   3840

attcaacctt gcatcagcca tttgttagcc aggtcactct gttctttgtc tgtaaatgag   3900

attgatcgtt gttcccactg agagtgtcag ctccttcccg tagagcaggc atgatgattg   3960

tactcacctc tgacaccatt gtgagtgcca cattccttcc cacgtccttg tcactgtaag   4020

agatgcccac ctgagcacca accccaggtt atcttcccct ttgtcttcca gccccccaga   4080

aacagctacg actcaaccta cccaatcatt tcatcatcag attgccactg tctctagttc   4140

aggtctcttg ggactggcac tcagaaatct cataataaat cctcttgagg cttctcatac   4200

actcgtcttc ttccaatctt ctttccctca aaatctcata ttttggttcc acttcaccca   4260

ccgtcattct ccatatcact cccaggagtt aggcaaaaag ccccttccgt tcttccgtat   4320

gttaaactta gaatcactct gttccctgct ctgcgtttct attttttgtt tttcctccat   4380

ttactagtag cttaacactt tctaacagtg ttcttattat tgatacgtat ctatctcttc   4440

cataagctta taaggtcacg gataatactt ctcattgtag tacgtaaatg acgtgggcta   4500

gatatgagtt gaataaacag ttatacctgt aaattcttac agagtgaaaa taaattgtta   4560

tactttacaa tttgtttctc tctttagacc atttccagga cttgtgatta ataaccgtga   4620

gtattttgtg aagtgttttg tttttgtttt ttcctggggt ctgacgtgtg tgcgtgtgag   4680

tgtgtataca tgcttaacgt atatcacgtt acttcaccta tgtcagtaac caggccaaat   4740

acttgtttta gccctcagta aaaacaccag gcacttccta gttgtaaaat tattcaagct   4800

tcttaacttc ctatcctcga tgcacttaat cataaaatgg taataatagc accgattttg   4860

ggggagtcgt tccagtagat ggaaagcatc tggaacaggt gtcagcaagc tcctgccgac   4920

gtgtatgcat aaagttttat tgaaaccacc atcgtgtcca tttgtttatg gcagaactga   4980

gagatggcag cagcaagtgt gtgcctgcaa aacctaaaat atttactaat tggctctgca   5040

agaaaagagt ttgcatcccc ctaacctaga acagtgtcta gcctctagta tgtgtttagc   5100

ctacagtatg tgctcagcga atacaatcta tatttattac tgcttttatg actgttataa   5160

ttactgtgct tggatttcgt tacaaagtaa gtcacaatgt gcctgcttct gttagtattt   5220

cagcacagtg cctggcacac atggggctct caaatattgc tgagcgagtg aacaaatgtc   5280

ctttcaattc cttaacgttg atgtcatttt caatagtatt ttgagccaaa cttaattttg   5340

cgagtgtgtt ttgttttctt aactttatta ttaaaaatgt ataaaagtga ggccaggcgt   5400

ggtggctcac gcctgtaatc ccagcagttt gggaggctga ggcaggcgga tcagttgagg   5460

ttgggagttg gagaccagcc cgtccaacat ggtgaaagcc tgtctctact aaaaatacaa   5520

aaatcagctg ggtgtggtgg cgcgtgcctg taatcccagc tactcaggag gctgaggcag   5580

gagagttgct tgaatcctag aggtggaggt tgcagtgagc tgagatcgtg ccattgcact   5640

ccagcctggg caacaagagc aaaactctgt cccaataaat aaataaataa aatgttctct   5700

tttgttcctg ttcttgtgcg gtagtgtggt atagagtttt atggtaatta ctgtgaatta   5760

gtgattctga gggacatatc agaactctga ggtttgtttc cttctcatct tgagggaaac   5820

agcaaatgta tgttaaaatg cttttccaag ggaacaacac atccttacat tatttaaacc   5880

aatctgcttc attttcagag ctggttgatc agagtgagtc agaaggcccc gtgatacaag   5940

aatcagctga accaagccag ttggaagttc cagccacaga agaaataaaa gagactgatg   6000

gaagctctca gatcaagcaa gaaccagacc ccacgtggta gacctcttcc ctcctagggt   6060

aaatcagctt ctgtgtcagg gatgctgtgt ggtgtccatc tgaaccccct gcatacgcgt   6120

agctaatgtg atctccccac tttcacataa gatggtggcc ctgccttcag ggaatgtggg   6180

agccaggtgg gagccttccc ggatatttaa gctagaagat tctacaggga gattctcctt   6240

ggatcaatat atgtctctca gtcaaagatg taaaagcact tttgccttaa aaagaatgtt   6300

ctgtttctaa atagagtcaa cgttgtcctc ctcattggaa ttcactatga gtcagaatca   6360

ttagactgac tttttttttt ccatagtaat agtattttgc agagtctcac agagctgcag   6420

atcttttgtt catcttgcag agttaacaag tctgatcctg ttagtccaga tttcttaaat   6480

ttggccaagt tataatagga gcagtagctt gagacccgaa gtcaggaaac tttgacaatg   6540

gatttttttt tttaatccag agacttgtac tggaatttgc cttaccctgt cagctcatgg   6600

acttaaggtt tcatcccgct ttatgagtgc ttctgaatcc aagtcattgt tacctgaatt   6660

tgcaaattaa gttgtgatat tcgtgactgt taaattcctg taattagatt aacctctttg   6720

cttgcttgtt tgttttctct cctattttag cttaaagtat cagtggttga gaagagcttt   6780

tcggacctgt tactacccca agctgtgtaa tatacttgta taacagaaat accttctata   6840

caaacctttt tttctacttt tagatagaaa tgtctacttt ttcagcagtt ctgtgaatta   6900

aagagcagag tgactgtggg tctggaatgg ctggtgtact tgggaatgta ctatcaggat   6960

tttacagcaa tgctgggaaa tgacagggaa aatgacagga atgaatctca ccagattttt   7020

tatgtactca gcagagcctt gagttacggt gtttattttc caatcaagtg aagatatctc   7080

ctacttctcc tactggaaca tctcagcttc tgcagtgaag aaaaattcct gtgatagttc   7140

agttctttag tttttctatt tgaaaaaaaa aaatcattta aatgatcctt tgttcacggc   7200

tctccttaat gactgagtga acagttccta tctgtatatt tgactaaacc ttttcctaag   7260

ctatctctca tggttcctat gtttttttat cataattaaa agcaaaacca tctggatcac   7320

ctaacagtca gaggtcagta tctcagcgtg tgaattatag aggaaataca gagagaacct   7380

cttccacttt tacttttcgt ccaaataaaa tgcatggtgt accagaagtt gaagatcggg   7440

ttgaggattg gggctagctc gatgacacta aggccccaac atcgcgggac ctgctgtggc   7500

gcggattctt aggaacgctg ttctagccgg ccccctctcc aggggtcgcc gtggccggca   7560

ttatttccta gttcttcttg taaccctgag gtgccagcgc ggggagtgag gaggggtcag   7620

ggggctaagg atgcaacctc tgacgttctg cgccttccta ggagagtctt acatgtgttg   7680

agatttcaca agcaatgcga gttgtaaaat accagctcta caagaagcta ggctctgtga   7740

cggcatagtt ttcagtagct ttatcacaat attcacaatg gagaattata tgacatggta   7800

gcagaaatag gcccttttat gtgttgcttc tattttacct caaattgtag atatagggta   7860

atcaataaaa tccatccatg cctttcacac actaagt                            7897


<210>  4433
<211>  896
<212>  PRT
<213>  Homo sapiens

<400>  4433

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr 
                565                 570                 575


Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys 
            580                 585                 590


Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro 
        595                 600                 605


Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys 
    610                 615                 620


Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val 
625                 630                 635                 640


Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg 
                645                 650                 655


Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly 
            660                 665                 670


Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys 
        675                 680                 685


Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly 
    690                 695                 700


Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro 
705                 710                 715                 720


Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg 
                725                 730                 735


Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys 
            740                 745                 750


Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala 
        755                 760                 765


Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser 
    770                 775                 780


Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile 
785                 790                 795                 800


Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val 
                805                 810                 815


Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg 
            820                 825                 830


Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr 
        835                 840                 845


Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro 
    850                 855                 860


Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met 
865                 870                 875                 880


Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
                885                 890                 895


<210>  4434
<211>  5144
<212>  DNA
<213>  Homo sapiens

<400>  4434
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   2040

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2100

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2160

atcaaacccg gagttcttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2220

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2280

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2340

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2400

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2460

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2520

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2580

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2640

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2700

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2760

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2820

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2880

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2940

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   3000

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3060

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca   3120

tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg   3180

atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag   3240

actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc   3300

ctagggtaaa tcagcttctg tgtcagggat gctgtgtggt gtccatctga accccctgca   3360

tacgcgtagc taatgtgatc tccccacttt cacataagat ggtggccctg ccttcaggga   3420

atgtgggagc caggtgggag ccttcccgga tatttaagct agaagattct acagggagat   3480

tctccttgga tcaatatatg tctctcagtc aaagatgtaa aagcactttt gccttaaaaa   3540

gaatgttctg tttctaaata gagtcaacgt tgtcctcctc attggaattc actatgagtc   3600

agaatcatta gactgacttt tttttttcca tagtaatagt attttgcaga gtctcacaga   3660

gctgcagatc ttttgttcat cttgcagagt taacaagtct gatcctgtta gtccagattt   3720

cttaaatttg gccaagttat aataggagca gtagcttgag acccgaagtc aggaaacttt   3780

gacaatggat tttttttttt aatccagaga cttgtactgg aatttgcctt accctgtcag   3840

ctcatggact taaggtttca tcccgcttta tgagtgcttc tgaatccaag tcattgttac   3900

ctgaatttgc aaattaagtt gtgatattcg tgactgttaa attcctgtaa ttagattaac   3960

ctctttgctt gcttgtttgt tttctctcct attttagctt aaagtatcag tggttgagaa   4020

gagcttttcg gacctgttac taccccaagc tgtgtaatat acttgtataa cagaaatacc   4080

ttctatacaa accttttttt ctacttttag atagaaatgt ctactttttc agcagttctg   4140

tgaattaaag agcagagtga ctgtgggtct ggaatggctg gtgtacttgg gaatgtacta   4200

tcaggatttt acagcaatgc tgggaaatga cagggaaaat gacaggaatg aatctcacca   4260

gattttttat gtactcagca gagccttgag ttacggtgtt tattttccaa tcaagtgaag   4320

atatctccta cttctcctac tggaacatct cagcttctgc agtgaagaaa aattcctgtg   4380

atagttcagt tctttagttt ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt   4440

tcacggctct ccttaatgac tgagtgaaca gttcctatct gtatatttga ctaaaccttt   4500

tcctaagcta tctctcatgg ttcctatgtt tttttatcat aattaaaagc aaaaccatct   4560

ggatcaccta acagtcagag gtcagtatct cagcgtgtga attatagagg aaatacagag   4620

agaacctctt ccacttttac ttttcgtcca aataaaatgc atggtgtacc agaagttgaa   4680

gatcgggttg aggattgggg ctagctcgat gacactaagg ccccaacatc gcgggacctg   4740

ctgtggcgcg gattcttagg aacgctgttc tagccggccc cctctccagg ggtcgccgtg   4800

gccggcatta tttcctagtt cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag   4860

gggtcagggg gctaaggatg caacctctga cgttctgcgc cttcctagga gagtcttaca   4920

tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc agctctacaa gaagctaggc   4980

tctgtgacgg catagttttc agtagcttta tcacaatatt cacaatggag aattatatga   5040

catggtagca gaaataggcc cttttatgtg ttgcttctat tttacctcaa attgtagata   5100

tagggtaatc aataaaatcc atccatgcct ttcacacact aagt                    5144


<210>  4435
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  4435

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
                565                 570                 575


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly 
            580                 585                 590


Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600


<210>  4436
<211>  5038
<212>  DNA
<213>  Homo sapiens

<400>  4436
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   1980

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   2040

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2100

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2160

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2220

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2280

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2340

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2400

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2460

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2520

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2580

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2640

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2700

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2760

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2820

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2880

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   2940

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   3000

cggtcattag accatttcca ggacttgtga ttaataacca gctggttgat cagagtgagt   3060

cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt ccagccacag   3120

aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac cccacgtggt   3180

agacctcttc cctcctaggg taaatcagct tctgtgtcag ggatgctgtg tggtgtccat   3240

ctgaaccccc tgcatacgcg tagctaatgt gatctcccca ctttcacata agatggtggc   3300

cctgccttca gggaatgtgg gagccaggtg ggagccttcc cggatattta agctagaaga   3360

ttctacaggg agattctcct tggatcaata tatgtctctc agtcaaagat gtaaaagcac   3420

ttttgcctta aaaagaatgt tctgtttcta aatagagtca acgttgtcct cctcattgga   3480

attcactatg agtcagaatc attagactga cttttttttt tccatagtaa tagtattttg   3540

cagagtctca cagagctgca gatcttttgt tcatcttgca gagttaacaa gtctgatcct   3600

gttagtccag atttcttaaa tttggccaag ttataatagg agcagtagct tgagacccga   3660

agtcaggaaa ctttgacaat ggattttttt ttttaatcca gagacttgta ctggaatttg   3720

ccttaccctg tcagctcatg gacttaaggt ttcatcccgc tttatgagtg cttctgaatc   3780

caagtcattg ttacctgaat ttgcaaatta agttgtgata ttcgtgactg ttaaattcct   3840

gtaattagat taacctcttt gcttgcttgt ttgttttctc tcctatttta gcttaaagta   3900

tcagtggttg agaagagctt ttcggacctg ttactacccc aagctgtgta atatacttgt   3960

ataacagaaa taccttctat acaaaccttt ttttctactt ttagatagaa atgtctactt   4020

tttcagcagt tctgtgaatt aaagagcaga gtgactgtgg gtctggaatg gctggtgtac   4080

ttgggaatgt actatcagga ttttacagca atgctgggaa atgacaggga aaatgacagg   4140

aatgaatctc accagatttt ttatgtactc agcagagcct tgagttacgg tgtttatttt   4200

ccaatcaagt gaagatatct cctacttctc ctactggaac atctcagctt ctgcagtgaa   4260

gaaaaattcc tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa aaaatcattt   4320

aaatgatcct ttgttcacgg ctctccttaa tgactgagtg aacagttcct atctgtatat   4380

ttgactaaac cttttcctaa gctatctctc atggttccta tgttttttta tcataattaa   4440

aagcaaaacc atctggatca cctaacagtc agaggtcagt atctcagcgt gtgaattata   4500

gaggaaatac agagagaacc tcttccactt ttacttttcg tccaaataaa atgcatggtg   4560

taccagaagt tgaagatcgg gttgaggatt ggggctagct cgatgacact aaggccccaa   4620

catcgcggga cctgctgtgg cgcggattct taggaacgct gttctagccg gccccctctc   4680

caggggtcgc cgtggccggc attatttcct agttcttctt gtaaccctga ggtgccagcg   4740

cggggagtga ggaggggtca gggggctaag gatgcaacct ctgacgttct gcgccttcct   4800

aggagagtct tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa taccagctct   4860

acaagaagct aggctctgtg acggcatagt tttcagtagc tttatcacaa tattcacaat   4920

ggagaattat atgacatggt agcagaaata ggccctttta tgtgttgctt ctattttacc   4980

tcaaattgta gatatagggt aatcaataaa atccatccat gcctttcaca cactaagt     5038


<210>  4437
<211>  865
<212>  PRT
<213>  Homo sapiens

<400>  4437

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
    450                 455                 460


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
465                 470                 475                 480


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
                485                 490                 495


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
            500                 505                 510


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
        515                 520                 525


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
    530                 535                 540


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
545                 550                 555                 560


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
                565                 570                 575


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
            580                 585                 590


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
        595                 600                 605


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
    610                 615                 620


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
625                 630                 635                 640


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
                645                 650                 655


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
            660                 665                 670


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
        675                 680                 685


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
    690                 695                 700


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
705                 710                 715                 720


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
                725                 730                 735


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
            740                 745                 750


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
        755                 760                 765


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
    770                 775                 780


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
785                 790                 795                 800


Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile 
                805                 810                 815


Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln 
            820                 825                 830


Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile 
        835                 840                 845


Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr 
    850                 855                 860


Trp 
865


<210>  4438
<211>  4002
<212>  DNA
<213>  Homo sapiens

<400>  4438
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   1980

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gcttagattt   2040

gttgacagcg gtttcctgga gtgctgtctt gagaacgatt ctgaggaggc tcagcaagaa   2100

agagtgtttc agttgattgg gtgtgtctgt catggagaag gaactcaagc tcttggactc   2160

accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgtatgtg   2220

gaaggcttgc cagaggggat tcccttccga agccctacct ggtttggaat tccacgactt   2280

gaaaggatcg tccgcgggag taataaaatc aagttcgttg ttaaaaaacc tgaactagtt   2340

atttcctact tgcctcctgg gatggctagt aaaataaaca ctaaagcttt gcagtccccc   2400

aaaagaccac gaagtcctgg gagtaattca aaggttcctg aaattgaggt caccgtggaa   2460

ggccctaata acaacaatcc tcaaacctca gctgttcgaa ccccgaccca gactaacggt   2520

tctaacgttc ccttcaagcc acgagggaga gagttttcct ttgaggcctg gaatgccaaa   2580

atcacggacc taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg ggaagctctt   2640

ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg agtctttccc ggaagacttt   2700

tatgtggaag gcttacctga gggtgtgcca ttccgaagac catcgacttt tggcattccg   2760

aggctggaga agatactcag aaacaaagcc aaaattaagt tcatcattaa aaagcccgaa   2820

atgtttgaga cggcgattaa ggagagcacc tcctctaaga gccctcccag aaaaataaat   2880

tcatcaccca atgttaatac tactgcatca ggtgttgaag accttaacat cattcaggtg   2940

acaattccag atgatgataa tgaaagactc tcgaaagttg aaaaagctag acagctaaga   3000

gaacaagtga atgacctctt tagtcggaaa tttggtgaag ctattggtat gggttttcct   3060

gtgaaagttc cctacaggaa aatcacaatt aaccctggct gtgtggtggt tgatggcatg   3120

cccccggggg tgtccttcaa agcccccagc tacctggaaa tcagctccat gagaaggatc   3180

ttagactctg ccgagtttat caaattcacg gtcattagac catttccagg acttgtgatt   3240

aataaccagc tggttgatca gagtgagtca gaaggccccg tgatacaaga atcagctgaa   3300

ccaagccagt tggaagttcc agccacagaa gaaataaaag agactgatgg aagctctcag   3360

atcaagcaag aaccagaccc cacgtggtag acctcttccc tcctaggcaa aaccatctgg   3420

atcacctaac agtcagaggt cagtatctca gcgtgtgaat tatagaggaa atacagagag   3480

aacctcttcc acttttactt ttcgtccaaa taaaatgcat ggtgtaccag aagttgaaga   3540

tcgggttgag gattggggct agctcgatga cactaaggcc ccaacatcgc gggacctgct   3600

gtggcgcgga ttcttaggaa cgctgttcta gccggccccc tctccagggg tcgccgtggc   3660

cggcattatt tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga gtgaggaggg   3720

gtcagggggc taaggatgca acctctgacg ttctgcgcct tcctaggaga gtcttacatg   3780

tgttgagatt tcacaagcaa tgcgagttgt aaaataccag ctctacaaga agctaggctc   3840

tgtgacggca tagttttcag tagctttatc acaatattca caatggagaa ttatatgaca   3900

tggtagcaga aataggccct tttatgtgtt gcttctattt tacctcaaat tgtagatata   3960

gggtaatcaa taaaatccat ccatgccttt cacacactaa gt                      4002


<210>  4439
<211>  544
<212>  PRT
<213>  Homo sapiens

<400>  4439

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile 
        515                 520                 525


Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  4440
<211>  5212
<212>  DNA
<213>  Homo sapiens

<400>  4440
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   1980

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2040

gaaatttgct tagatttgtt gacagcggtt tcctggagtg ctgtcttgag aacgattctg   2100

aggaggctca gcaagaaaga gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa   2160

ctcaagctct tggactcacc gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc   2220

cggagttctt gtatgtggaa ggcttgccag aggggattcc cttccgaagc cctacctggt   2280

ttggaattcc acgacttgaa aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta   2340

aaaaacctga actagttatt tcctacttgc ctcctgggat ggctagtaaa ataaacacta   2400

aagctttgca gtcccccaaa agaccacgaa gtcctgggag taattcaaag gttcctgaaa   2460

ttgaggtcac cgtggaaggc cctaataaca acaatcctca aacctcagct gttcgaaccc   2520

cgacccagac taacggttct aacgttccct tcaagccacg agggagagag ttttcctttg   2580

aggcctggaa tgccaaaatc acggacctaa aacagaaagt tgaaaatctc ttcaatgaga   2640

aatgtgggga agctcttggc cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt   2700

ctttcccgga agacttttat gtggaaggct tacctgaggg tgtgccattc cgaagaccat   2760

cgacttttgg cattccgagg ctggagaaga tactcagaaa caaagccaaa attaagttca   2820

tcattaaaaa gcccgaaatg tttgagacgg cgattaagga gagcacctcc tctaagagcc   2880

ctcccagaaa aataaattca tcacccaatg ttaatactac tgcatcaggt gttgaagacc   2940

ttaacatcat tcaggtgaca attccagatg atgataatga aagactctcg aaagttgaaa   3000

aagctagaca gctaagagaa caagtgaatg acctctttag tcggaaattt ggtgaagcta   3060

ttggtatggg ttttcctgtg aaagttccct acaggaaaat cacaattaac cctggctgtg   3120

tggtggttga tggcatgccc ccgggggtgt ccttcaaagc ccccagctac ctggaaatca   3180

gctccatgag aaggatctta gactctgccg agtttatcaa attcacggtc attagaccat   3240

ttccaggact tgtgattaat aaccagctgg ttgatcagag tgagtcagaa ggccccgtga   3300

tacaagaatc agctgaacca agccagttgg aagttccagc cacagaaggt aaaaggacct   3360

cttccctcct agggtaaatc agcttctgtg tcagggatgc tgtgtggtgt ccatctgaac   3420

cccctgcata cgcgtagcta atgtgatctc cccactttca cataagatgg tggccctgcc   3480

ttcagggaat gtgggagcca ggtgggagcc ttcccggata tttaagctag aagattctac   3540

agggagattc tccttggatc aatatatgtc tctcagtcaa agatgtaaaa gcacttttgc   3600

cttaaaaaga atgttctgtt tctaaataga gtcaacgttg tcctcctcat tggaattcac   3660

tatgagtcag aatcattaga ctgacttttt tttttccata gtaatagtat tttgcagagt   3720

ctcacagagc tgcagatctt ttgttcatct tgcagagtta acaagtctga tcctgttagt   3780

ccagatttct taaatttggc caagttataa taggagcagt agcttgagac ccgaagtcag   3840

gaaactttga caatggattt ttttttttaa tccagagact tgtactggaa tttgccttac   3900

cctgtcagct catggactta aggtttcatc ccgctttatg agtgcttctg aatccaagtc   3960

attgttacct gaatttgcaa attaagttgt gatattcgtg actgttaaat tcctgtaatt   4020

agattaacct ctttgcttgc ttgtttgttt tctctcctat tttagcttaa agtatcagtg   4080

gttgagaaga gcttttcgga cctgttacta ccccaagctg tgtaatatac ttgtataaca   4140

gaaatacctt ctatacaaac ctttttttct acttttagat agaaatgtct actttttcag   4200

cagttctgtg aattaaagag cagagtgact gtgggtctgg aatggctggt gtacttggga   4260

atgtactatc aggattttac agcaatgctg ggaaatgaca gggaaaatga caggaatgaa   4320

tctcaccaga ttttttatgt actcagcaga gccttgagtt acggtgttta ttttccaatc   4380

aagtgaagat atctcctact tctcctactg gaacatctca gcttctgcag tgaagaaaaa   4440

ttcctgtgat agttcagttc tttagttttt ctatttgaaa aaaaaaaatc atttaaatga   4500

tcctttgttc acggctctcc ttaatgactg agtgaacagt tcctatctgt atatttgact   4560

aaaccttttc ctaagctatc tctcatggtt cctatgtttt tttatcataa ttaaaagcaa   4620

aaccatctgg atcacctaac agtcagaggt cagtatctca gcgtgtgaat tatagaggaa   4680

atacagagag aacctcttcc acttttactt ttcgtccaaa taaaatgcat ggtgtaccag   4740

aagttgaaga tcgggttgag gattggggct agctcgatga cactaaggcc ccaacatcgc   4800

gggacctgct gtggcgcgga ttcttaggaa cgctgttcta gccggccccc tctccagggg   4860

tcgccgtggc cggcattatt tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga   4920

gtgaggaggg gtcagggggc taaggatgca acctctgacg ttctgcgcct tcctaggaga   4980

gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt aaaataccag ctctacaaga   5040

agctaggctc tgtgacggca tagttttcag tagctttatc acaatattca caatggagaa   5100

ttatatgaca tggtagcaga aataggccct tttatgtgtt gcttctattt tacctcaaat   5160

tgtagatata gggtaatcaa taaaatccat ccatgccttt cacacactaa gt           5212


<210>  4441
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  4441

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  4442
<211>  4299
<212>  DNA
<213>  Homo sapiens

<400>  4442
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1980

aagagatttt taatttgaaa tttgcttaga tttgttgaca gcggtttcct ggagtgctgt   2040

cttgagaacg attctgagga ggctcagcaa gaaagagtgt ttcagttgat tgggtgtgtc   2100

tgtcatggag aaggaactca agctcttgga ctcaccgagg cagtaaaagt accatatcct   2160

gtgtttgaat caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc   2220

cgaagcccta cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa   2280

atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct   2340

agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat   2400

tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc   2460

tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg   2520

agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa   2580

aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg   2640

ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg   2700

ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa   2760

gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc   2820

acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca   2880

tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga   2940

ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg   3000

aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca   3060

attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt caaagccccc   3120

agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc   3180

acggtcatta gaccatttcc aggacttgtg attaataacc agctggttga tcagagtgag   3240

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   3300

gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga ccccacgtgg   3360

tagacctctt ccctcctagg cttaaagtat cagtggttga gaagagcttt tcggacctgt   3420

tactacccca agctgtagcc ttgagttacg gtgtttattt tccaatcaag tgaagatatc   3480

tcctacttct cctactggaa catctcagct tctgcagtga agaaaaattc ctgtgatagt   3540

tcagttcttt agtttttcta tttgaaaaaa aaaaatcatt taaatgatcc tttgttcacg   3600

gctctcctta atgactgagt gaacagttcc tatctgtata tttgactaaa ccttttccta   3660

agctatctct catggttcct atgttttttt atcataatta aaagcaaaac catctggatc   3720

acctaacagt cagaggtcag tatctcagcg tgtgaattat agaggaaata cagagagaac   3780

ctcttccact tttacttttc gtccaaataa aatgcatggt gtaccagaag ttgaagatcg   3840

ggttgaggat tggggctagc tcgatgacac taaggcccca acatcgcggg acctgctgtg   3900

gcgcggattc ttaggaacgc tgttctagcc ggccccctct ccaggggtcg ccgtggccgg   3960

cattatttcc tagttcttct tgtaaccctg aggtgccagc gcggggagtg aggaggggtc   4020

agggggctaa ggatgcaacc tctgacgttc tgcgccttcc taggagagtc ttacatgtgt   4080

tgagatttca caagcaatgc gagttgtaaa ataccagctc tacaagaagc taggctctgt   4140

gacggcatag ttttcagtag ctttatcaca atattcacaa tggagaatta tatgacatgg   4200

tagcagaaat aggccctttt atgtgttgct tctattttac ctcaaattgt agatataggg   4260

taatcaataa aatccatcca tgcctttcac acactaagt                          4299


<210>  4443
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  4443

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
    450                 455                 460


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
465                 470


<210>  4444
<211>  4239
<212>  DNA
<213>  Homo sapiens

<400>  4444
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgcttaga tttgttgaca gcggtttcct ggagtgctgt   1980

cttgagaacg attctgagga ggctcagcaa gaaagagtgt ttcagttgat tgggtgtgtc   2040

tgtcatggag aaggaactca agctcttgga ctcaccgagg cagtaaaagt accatatcct   2100

gtgtttgaat caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc   2160

cgaagcccta cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa   2220

atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct   2280

agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat   2340

tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc   2400

tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg   2460

agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa   2520

aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg   2580

ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg   2640

ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa   2700

gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc   2760

acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca   2820

tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga   2880

ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg   2940

aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca   3000

attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt caaagccccc   3060

agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc   3120

acggtcatta gaccatttcc aggacttgtg attaataacc agctggttga tcagagtgag   3180

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   3240

gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga ccccacgtgg   3300

tagacctctt ccctcctagg cttaaagtat cagtggttga gaagagcttt tcggacctgt   3360

tactacccca agctgtagcc ttgagttacg gtgtttattt tccaatcaag tgaagatatc   3420

tcctacttct cctactggaa catctcagct tctgcagtga agaaaaattc ctgtgatagt   3480

tcagttcttt agtttttcta tttgaaaaaa aaaaatcatt taaatgatcc tttgttcacg   3540

gctctcctta atgactgagt gaacagttcc tatctgtata tttgactaaa ccttttccta   3600

agctatctct catggttcct atgttttttt atcataatta aaagcaaaac catctggatc   3660

acctaacagt cagaggtcag tatctcagcg tgtgaattat agaggaaata cagagagaac   3720

ctcttccact tttacttttc gtccaaataa aatgcatggt gtaccagaag ttgaagatcg   3780

ggttgaggat tggggctagc tcgatgacac taaggcccca acatcgcggg acctgctgtg   3840

gcgcggattc ttaggaacgc tgttctagcc ggccccctct ccaggggtcg ccgtggccgg   3900

cattatttcc tagttcttct tgtaaccctg aggtgccagc gcggggagtg aggaggggtc   3960

agggggctaa ggatgcaacc tctgacgttc tgcgccttcc taggagagtc ttacatgtgt   4020

tgagatttca caagcaatgc gagttgtaaa ataccagctc tacaagaagc taggctctgt   4080

gacggcatag ttttcagtag ctttatcaca atattcacaa tggagaatta tatgacatgg   4140

tagcagaaat aggccctttt atgtgttgct tctattttac ctcaaattgt agatataggg   4200

taatcaataa aatccatcca tgcctttcac acactaagt                          4239


<210>  4445
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  4445

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
            420                 425                 430


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
        435                 440                 445


Phe Asn Leu Lys Phe Ala 
    450


<210>  4446
<211>  5197
<212>  DNA
<213>  Homo sapiens

<400>  4446
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gtcaaagaag attggaatgt   1980

cagaattacc aagctacgga agcaagtgga agagattttt aatttgaaat ttgcttagat   2040

ttgttgacag cggtttcctg gagtgctgtc ttgagaacga ttctgaggag gctcagcaag   2100

aaagagtgtt tcagttgatt gggtgtgtct gtcatggaga aggaactcaa gctcttggac   2160

tcaccgaggc agtaaaagta ccatatcctg tgtttgaatc aaacccggag ttcttgtatg   2220

tggaaggctt gccagagggg attcccttcc gaagccctac ctggtttgga attccacgac   2280

ttgaaaggat cgtccgcggg agtaataaaa tcaagttcgt tgttaaaaaa cctgaactag   2340

ttatttccta cttgcctcct gggatggcta gtaaaataaa cactaaagct ttgcagtccc   2400

ccaaaagacc acgaagtcct gggagtaatt caaaggttcc tgaaattgag gtcaccgtgg   2460

aaggccctaa taacaacaat cctcaaacct cagctgttcg aaccccgacc cagactaacg   2520

gttctaacgt tcccttcaag ccacgaggga gagagttttc ctttgaggcc tggaatgcca   2580

aaatcacgga cctaaaacag aaagttgaaa atctcttcaa tgagaaatgt ggggaagctc   2640

ttggccttaa acaagctgtg aaggtgccgt tcgcgttatt tgagtctttc ccggaagact   2700

tttatgtgga aggcttacct gagggtgtgc cattccgaag accatcgact tttggcattc   2760

cgaggctgga gaagatactc agaaacaaag ccaaaattaa gttcatcatt aaaaagcccg   2820

aaatgtttga gacggcgatt aaggagagca cctcctctaa gagccctccc agaaaaataa   2880

attcatcacc caatgttaat actactgcat caggtgttga agaccttaac atcattcagg   2940

tgacaattcc agatgatgat aatgaaagac tctcgaaagt tgaaaaagct agacagctaa   3000

gagaacaagt gaatgacctc tttagtcgga aatttggtga agctattggt atgggttttc   3060

ctgtgaaagt tccctacagg aaaatcacaa ttaaccctgg ctgtgtggtg gttgatggca   3120

tgcccccggg ggtgtccttc aaagccccca gctacctgga aatcagctcc atgagaagga   3180

tcttagactc tgccgagttt atcaaattca cggtcattag accatttcca ggacttgtga   3240

ttaataacca gctggttgat cagagtgagt cagaaggccc cgtgatacaa gaatcagctg   3300

aaccaagcca gttggaagtt ccagccacag aaggtaaaag gacctcttcc ctcctagggt   3360

aaatcagctt ctgtgtcagg gatgctgtgt ggtgtccatc tgaaccccct gcatacgcgt   3420

agctaatgtg atctccccac tttcacataa gatggtggcc ctgccttcag ggaatgtggg   3480

agccaggtgg gagccttccc ggatatttaa gctagaagat tctacaggga gattctcctt   3540

ggatcaatat atgtctctca gtcaaagatg taaaagcact tttgccttaa aaagaatgtt   3600

ctgtttctaa atagagtcaa cgttgtcctc ctcattggaa ttcactatga gtcagaatca   3660

ttagactgac tttttttttt ccatagtaat agtattttgc agagtctcac agagctgcag   3720

atcttttgtt catcttgcag agttaacaag tctgatcctg ttagtccaga tttcttaaat   3780

ttggccaagt tataatagga gcagtagctt gagacccgaa gtcaggaaac tttgacaatg   3840

gatttttttt tttaatccag agacttgtac tggaatttgc cttaccctgt cagctcatgg   3900

acttaaggtt tcatcccgct ttatgagtgc ttctgaatcc aagtcattgt tacctgaatt   3960

tgcaaattaa gttgtgatat tcgtgactgt taaattcctg taattagatt aacctctttg   4020

cttgcttgtt tgttttctct cctattttag cttaaagtat cagtggttga gaagagcttt   4080

tcggacctgt tactacccca agctgtgtaa tatacttgta taacagaaat accttctata   4140

caaacctttt tttctacttt tagatagaaa tgtctacttt ttcagcagtt ctgtgaatta   4200

aagagcagag tgactgtggg tctggaatgg ctggtgtact tgggaatgta ctatcaggat   4260

tttacagcaa tgctgggaaa tgacagggaa aatgacagga atgaatctca ccagattttt   4320

tatgtactca gcagagcctt gagttacggt gtttattttc caatcaagtg aagatatctc   4380

ctacttctcc tactggaaca tctcagcttc tgcagtgaag aaaaattcct gtgatagttc   4440

agttctttag tttttctatt tgaaaaaaaa aaatcattta aatgatcctt tgttcacggc   4500

tctccttaat gactgagtga acagttccta tctgtatatt tgactaaacc ttttcctaag   4560

ctatctctca tggttcctat gtttttttat cataattaaa agcaaaacca tctggatcac   4620

ctaacagtca gaggtcagta tctcagcgtg tgaattatag aggaaataca gagagaacct   4680

cttccacttt tacttttcgt ccaaataaaa tgcatggtgt accagaagtt gaagatcggg   4740

ttgaggattg gggctagctc gatgacacta aggccccaac atcgcgggac ctgctgtggc   4800

gcggattctt aggaacgctg ttctagccgg ccccctctcc aggggtcgcc gtggccggca   4860

ttatttccta gttcttcttg taaccctgag gtgccagcgc ggggagtgag gaggggtcag   4920

ggggctaagg atgcaacctc tgacgttctg cgccttccta ggagagtctt acatgtgttg   4980

agatttcaca agcaatgcga gttgtaaaat accagctcta caagaagcta ggctctgtga   5040

cggcatagtt ttcagtagct ttatcacaat attcacaatg gagaattata tgacatggta   5100

gcagaaatag gcccttttat gtgttgcttc tattttacct caaattgtag atatagggta   5160

atcaataaaa tccatccatg cctttcacac actaagt                            5197


<210>  4447
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  4447

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535


<210>  4448
<211>  3835
<212>  DNA
<213>  Homo sapiens

<400>  4448
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagctca   1980

agctcttgga ctcaccgagg cagtaaaagt accatatcct gtgtttgaat caaacccgga   2040

gttcttgtat gtggaaggct tgccagaggg gattcccttc cgaagcccta cctggtttgg   2100

aattccacga cttgaaagga tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa   2160

acctgaacta gttatttcct acttgcctcc tgggatggct agtaaaataa acactaaagc   2220

tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga   2280

ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc tcagctgttc gaaccccgac   2340

ccagactaac ggttctaacg ttcccttcaa gccacgaggg agagagtttt cctttgaggc   2400

ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa aatctcttca atgagaaatg   2460

tggggaagct cttggcctta aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt   2520

cccggaagac ttttatgtgg aaggcttacc tgagggtgtg ccattccgaa gaccatcgac   2580

ttttggcatt ccgaggctgg agaagatact cagaaacaaa gccaaaatta agttcatcat   2640

taaaaagccc gaaatgtttg agacggcgat taaggagagc acctcctcta agagccctcc   2700

cagaaaaata aattcatcac ccaatgttaa tactactgca tcaggtgttg aagaccttaa   2760

catcattcag gtgacaattc cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc   2820

tagacagcta agagaacaag tgaatgacct ctttagtcgg aaatttggtg aagctattgg   2880

tatgggtttt cctgtgaaag ttccctacag gaaaatcaca attaaccctg gctgtgtggt   2940

ggttgatggc atgcccccgg gggtgtcctt caaagccccc agctacctgg aaatcagctc   3000

catgagaagg atcttagact ctgccgagtt tatcaaattc acggtcatta gaccatttcc   3060

aggacttgtg attaataacc agctggttga tcagagtgag tcagaaggcc ccgtgataca   3120

agaatcagct gaaccaagcc agttggaagt tccagccaca gaagaaataa aagagactga   3180

tggaagctct cagatcaagc aagaaccaga ccccacgtgg tagacctctt ccctcctagg   3240

caaaaccatc tggatcacct aacagtcaga ggtcagtatc tcagcgtgtg aattatagag   3300

gaaatacaga gagaacctct tccactttta cttttcgtcc aaataaaatg catggtgtac   3360

cagaagttga agatcgggtt gaggattggg gctagctcga tgacactaag gccccaacat   3420

cgcgggacct gctgtggcgc ggattcttag gaacgctgtt ctagccggcc ccctctccag   3480

gggtcgccgt ggccggcatt atttcctagt tcttcttgta accctgaggt gccagcgcgg   3540

ggagtgagga ggggtcaggg ggctaaggat gcaacctctg acgttctgcg ccttcctagg   3600

agagtcttac atgtgttgag atttcacaag caatgcgagt tgtaaaatac cagctctaca   3660

agaagctagg ctctgtgacg gcatagtttt cagtagcttt atcacaatat tcacaatgga   3720

gaattatatg acatggtagc agaaataggc ccttttatgt gttgcttcta ttttacctca   3780

aattgtagat atagggtaat caataaaatc catccatgcc tttcacacac taagt        3835


<210>  4449
<211>  933
<212>  PRT
<213>  Homo sapiens

<400>  4449

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
        515                 520                 525


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
    530                 535                 540


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
545                 550                 555                 560


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
                565                 570                 575


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
            580                 585                 590


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
        595                 600                 605


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
    610                 615                 620


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
625                 630                 635                 640


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
                645                 650                 655


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
            660                 665                 670


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
        675                 680                 685


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
    690                 695                 700


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
705                 710                 715                 720


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
                725                 730                 735


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
            740                 745                 750


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
        755                 760                 765


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
    770                 775                 780


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
785                 790                 795                 800


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
                805                 810                 815


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
            820                 825                 830


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
        835                 840                 845


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
    850                 855                 860


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro 
865                 870                 875                 880


Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly 
                885                 890                 895


Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala 
            900                 905                 910


Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu 
        915                 920                 925


Pro Asp Pro Thr Trp 
    930


<210>  4450
<211>  7029
<212>  DNA
<213>  Homo sapiens

<400>  4450
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagctc   1860

aagctcttgg actcaccgag gcagtaaaag taccatatcc tgtgtttgaa tcaaacccgg   1920

agttcttgta tgtggaaggc ttgccagagg ggattccctt ccgaagccct acctggtttg   1980

gaattccacg acttgaaagg atcgtccgcg ggagtaataa aatcaagttc gttgttaaaa   2040

aacctgaact agttatttcc tacttgcctc ctgggatggc tagtaaaata aacactaaag   2100

ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa ttcaaaggtt cctgaaattg   2160

aggtcaccgt ggaaggccct aataacaaca atcctcaaac ctcagctgtt cgaaccccga   2220

cccagactaa cggttctaac gttcccttca agccacgagg gagagagttt tcctttgagg   2280

cctggaatgc caaaatcacg gacctaaaac agaaagttga aaatctcttc aatgagaaat   2340

gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc gttcgcgtta tttgagtctt   2400

tcccggaaga cttttatgtg gaaggcttac ctgagggtgt gccattccga agaccatcga   2460

cttttggcat tccgaggctg gagaagatac tcagaaacaa agccaaaatt aagttcatca   2520

ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag cacctcctct aagagccctc   2580

ccagaaaaat aaattcatca cccaatgtta atactactgc atcaggtgtt gaagacctta   2640

acatcattca ggtgacaatt ccagatgatg ataatgaaag actctcgaaa gttgaaaaag   2700

ctagacagct aagagaacaa gtgaatgacc tctttagtcg gaaatttggt gaagctattg   2760

gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac aattaaccct ggctgtgtgg   2820

tggttgatgg catgcccccg ggggtgtcct tcaaagcccc cagctacctg gaaatcagct   2880

ccatgagaag gatcttagac tctgccgagt ttatcaaatt cacggtcatt aggtaagtga   2940

gagtttcctg cttagtcaca ggagcgaatc tggagctcat gaggctgact cttctaaaat   3000

gcagccacag gtagtcatcg aatccggctt cctatgctgt gcaatcaaca aatcaaaata   3060

acttgtgtca tcattagaat gtcagatgtg cttctacgaa ctaagctgac tcttttaatt   3120

ctttggcaaa gggttggcaa actaggactg tttgccaaat tcaggctgcc tcctattttt   3180

agagtcttcc tgaaacacag ctacacccgt attatccatg gctgctttcc tgtcacagtg   3240

agtaagtagc tgggactgag aaggcatggc ctccaaagtc taaaatattt actctctagc   3300

actttgtaga aaaaccttag ctaggcacag tggctaacgc ctgtaatccc agcattttgg   3360

gaggccaagg caggcagatc acctgaggtc aggagttcca gaccagcctg gccaacatgg   3420

tgaaatccca tctctacaaa aataaaacag ttagctgggc atgatggcgg gtgcctgtaa   3480

tcccagctac tcgggaggct gaggcaggat agtcgcttga acccaggagg tggaggttgc   3540

aatgagccaa gatcatgcca ctgcactcca gcctggacga cagagtgaga ctccatcaca   3600

agaaaaaaag aactttgtca acctctgtct tagggcgcct tgtcacaggc ttcgggtcag   3660

acggattcaa ccttgcatca gccatttgtt agccaggtca ctctgttctt tgtctgtaaa   3720

tgagattgat cgttgttccc actgagagtg tcagctcctt cccgtagagc aggcatgatg   3780

attgtactca cctctgacac cattgtgagt gccacattcc ttcccacgtc cttgtcactg   3840

taagagatgc ccacctgagc accaacccca ggttatcttc ccctttgtct tccagccccc   3900

cagaaacagc tacgactcaa cctacccaat catttcatca tcagattgcc actgtctcta   3960

gttcaggtct cttgggactg gcactcagaa atctcataat aaatcctctt gaggcttctc   4020

atacactcgt cttcttccaa tcttctttcc ctcaaaatct catattttgg ttccacttca   4080

cccaccgtca ttctccatat cactcccagg agttaggcaa aaagcccctt ccgttcttcc   4140

gtatgttaaa cttagaatca ctctgttccc tgctctgcgt ttctattttt tgtttttcct   4200

ccatttacta gtagcttaac actttctaac agtgttctta ttattgatac gtatctatct   4260

cttccataag cttataaggt cacggataat acttctcatt gtagtacgta aatgacgtgg   4320

gctagatatg agttgaataa acagttatac ctgtaaattc ttacagagtg aaaataaatt   4380

gttatacttt acaatttgtt tctctcttta gaccatttcc aggacttgtg attaataacc   4440

gtgagtattt tgtgaagtgt tttgtttttg ttttttcctg gggtctgacg tgtgtgcgtg   4500

tgagtgtgta tacatgctta acgtatatca cgttacttca cctatgtcag taaccaggcc   4560

aaatacttgt tttagccctc agtaaaaaca ccaggcactt cctagttgta aaattattca   4620

agcttcttaa cttcctatcc tcgatgcact taatcataaa atggtaataa tagcaccgat   4680

tttgggggag tcgttccagt agatggaaag catctggaac aggtgtcagc aagctcctgc   4740

cgacgtgtat gcataaagtt ttattgaaac caccatcgtg tccatttgtt tatggcagaa   4800

ctgagagatg gcagcagcaa gtgtgtgcct gcaaaaccta aaatatttac taattggctc   4860

tgcaagaaaa gagtttgcat ccccctaacc tagaacagtg tctagcctct agtatgtgtt   4920

tagcctacag tatgtgctca gcgaatacaa tctatattta ttactgcttt tatgactgtt   4980

ataattactg tgcttggatt tcgttacaaa gtaagtcaca atgtgcctgc ttctgttagt   5040

atttcagcac agtgcctggc acacatgggg ctctcaaata ttgctgagcg agtgaacaaa   5100

tgtcctttca attccttaac gttgatgtca ttttcaatag tattttgagc caaacttaat   5160

tttgcgagtg tgttttgttt tcttaacttt attattaaaa atgtataaaa gtgaggccag   5220

gcgtggtggc tcacgcctgt aatcccagca gtttgggagg ctgaggcagg cggatcagtt   5280

gaggttggga gttggagacc agcccgtcca acatggtgaa agcctgtctc tactaaaaat   5340

acaaaaatca gctgggtgtg gtggcgcgtg cctgtaatcc cagctactca ggaggctgag   5400

gcaggagagt tgcttgaatc ctagaggtgg aggttgcagt gagctgagat cgtgccattg   5460

cactccagcc tgggcaacaa gagcaaaact ctgtcccaat aaataaataa ataaaatgtt   5520

ctcttttgtt cctgttcttg tgcggtagtg tggtatagag ttttatggta attactgtga   5580

attagtgatt ctgagggaca tatcagaact ctgaggtttg tttccttctc atcttgaggg   5640

aaacagcaaa tgtatgttaa aatgcttttc caagggaaca acacatcctt acattattta   5700

aaccaatctg cttcattttc agagctggtt gatcagagtg agtcagaagg ccccgtgata   5760

caagaatcag ctgaaccaag ccagttggaa gttccagcca cagaagaaat aaaagagact   5820

gatggaagct ctcagatcaa gcaagaacca gaccccacgt ggtagacctc ttccctccta   5880

ggcttaaagt atcagtggtt gagaagagct tttcggacct gttactaccc caagctgtgt   5940

aatatacttg tataacagaa ataccttcta tacaaacctt tttttctact tttagataga   6000

aatgtctact ttttcagcag ttctgtgaat taaagagcag agtgactgtg ggtctggaat   6060

ggctggtgta cttgggaatg tactatcagg attttacagc aatgctggga aatgacaggg   6120

aaaatgacag gaatgaatct caccagattt tttatgtact cagcagagcc ttgagttacg   6180

gtgtttattt tccaatcaag tgaagatatc tcctacttct cctactggaa catctcagct   6240

tctgcagtga agaaaaattc ctgtgatagt tcagttcttt agtttttcta tttgaaaaaa   6300

aaaaatcatt taaatgatcc tttgttcacg gctctcctta atgactgagt gaacagttcc   6360

tatctgtata tttgactaaa ccttttccta agctatctct catggttcct atgttttttt   6420

atcataatta aaagcaaaac catctggatc acctaacagt cagaggtcag tatctcagcg   6480

tgtgaattat agaggaaata cagagagaac ctcttccact tttacttttc gtccaaataa   6540

aatgcatggt gtaccagaag ttgaagatcg ggttgaggat tggggctagc tcgatgacac   6600

taaggcccca acatcgcggg acctgctgtg gcgcggattc ttaggaacgc tgttctagcc   6660

ggccccctct ccaggggtcg ccgtggccgg cattatttcc tagttcttct tgtaaccctg   6720

aggtgccagc gcggggagtg aggaggggtc agggggctaa ggatgcaacc tctgacgttc   6780

tgcgccttcc taggagagtc ttacatgtgt tgagatttca caagcaatgc gagttgtaaa   6840

ataccagctc tacaagaagc taggctctgt gacggcatag ttttcagtag ctttatcaca   6900

atattcacaa tggagaatta tatgacatgg tagcagaaat aggccctttt atgtgttgct   6960

tctattttac ctcaaattgt agatataggg taatcaataa aatccatcca tgcctttcac   7020

acactaagt                                                           7029


<210>  4451
<211>  783
<212>  PRT
<213>  Homo sapiens

<400>  4451

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu 
            420                 425                 430


Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu 
        435                 440                 445


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp 
    450                 455                 460


Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile 
465                 470                 475                 480


Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro 
                485                 490                 495


Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg 
            500                 505                 510


Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr 
        515                 520                 525


Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr 
    530                 535                 540


Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg 
545                 550                 555                 560


Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln 
                565                 570                 575


Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu 
            580                 585                 590


Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu 
        595                 600                 605


Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro 
    610                 615                 620


Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala 
625                 630                 635                 640


Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile 
                645                 650                 655


Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser 
            660                 665                 670


Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile 
        675                 680                 685


Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu 
    690                 695                 700


Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys 
705                 710                 715                 720


Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg 
                725                 730                 735


Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro 
            740                 745                 750


Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg 
        755                 760                 765


Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
    770                 775                 780


<210>  4452
<211>  7172
<212>  DNA
<213>  Homo sapiens

<400>  4452
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   2040

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2100

taccatatcc tgtgtttgaa tcaaacccgg agttcttgaa aggatcgtcc gcgggagtaa   2160

taaaatcaag ttcgttgtta aaaaacctga actagttatt tcctacttgc ctcctgggat   2220

ggctagtaaa ataaacacta aagctttgca gtcccccaaa agaccacgaa gtcctgggag   2280

taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc cctaataaca acaatcctca   2340

aacctcagct gttcgaaccc cgacccagac taacggttct aacgttccct tcaagccacg   2400

agggagagag ttttcctttg aggcctggaa tgccaaaatc acggacctaa aacagaaagt   2460

tgaaaatctc ttcaatgaga aatgtgggga agctcttggc cttaaacaag ctgtgaaggt   2520

gccgttcgcg ttatttgagt ctttcccgga agacttttat gtggaaggct tacctgaggg   2580

tgtgccattc cgaagaccat cgacttttgg cattccgagg ctggagaaga tactcagaaa   2640

caaagccaaa attaagttca tcattaaaaa gcccgaaatg tttgagacgg cgattaagga   2700

gagcacctcc tctaagagcc ctcccagaaa aataaattca tcacccaatg ttaatactac   2760

tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca attccagatg atgataatga   2820

aagactctcg aaagttgaaa aagctagaca gctaagagaa caagtgaatg acctctttag   2880

tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg aaagttccct acaggaaaat   2940

cacaattaac cctggctgtg tggtggttga tggcatgccc ccgggggtgt ccttcaaagc   3000

ccccagctac ctggaaatca gctccatgag aaggatctta gactctgccg agtttatcaa   3060

attcacggtc attaggtaag tgagagtttc ctgcttagtc acaggagcga atctggagct   3120

catgaggctg actcttctaa aatgcagcca caggtagtca tcgaatccgg cttcctatgc   3180

tgtgcaatca acaaatcaaa ataacttgtg tcatcattag aatgtcagat gtgcttctac   3240

gaactaagct gactctttta attctttggc aaagggttgg caaactagga ctgtttgcca   3300

aattcaggct gcctcctatt tttagagtct tcctgaaaca cagctacacc cgtattatcc   3360

atggctgctt tcctgtcaca gtgagtaagt agctgggact gagaaggcat ggcctccaaa   3420

gtctaaaata tttactctct agcactttgt agaaaaacct tagctaggca cagtggctaa   3480

cgcctgtaat cccagcattt tgggaggcca aggcaggcag atcacctgag gtcaggagtt   3540

ccagaccagc ctggccaaca tggtgaaatc ccatctctac aaaaataaaa cagttagctg   3600

ggcatgatgg cgggtgcctg taatcccagc tactcgggag gctgaggcag gatagtcgct   3660

tgaacccagg aggtggaggt tgcaatgagc caagatcatg ccactgcact ccagcctgga   3720

cgacagagtg agactccatc acaagaaaaa aagaactttg tcaacctctg tcttagggcg   3780

ccttgtcaca ggcttcgggt cagacggatt caaccttgca tcagccattt gttagccagg   3840

tcactctgtt ctttgtctgt aaatgagatt gatcgttgtt cccactgaga gtgtcagctc   3900

cttcccgtag agcaggcatg atgattgtac tcacctctga caccattgtg agtgccacat   3960

tccttcccac gtccttgtca ctgtaagaga tgcccacctg agcaccaacc ccaggttatc   4020

ttcccctttg tcttccagcc ccccagaaac agctacgact caacctaccc aatcatttca   4080

tcatcagatt gccactgtct ctagttcagg tctcttggga ctggcactca gaaatctcat   4140

aataaatcct cttgaggctt ctcatacact cgtcttcttc caatcttctt tccctcaaaa   4200

tctcatattt tggttccact tcacccaccg tcattctcca tatcactccc aggagttagg   4260

caaaaagccc cttccgttct tccgtatgtt aaacttagaa tcactctgtt ccctgctctg   4320

cgtttctatt ttttgttttt cctccattta ctagtagctt aacactttct aacagtgttc   4380

ttattattga tacgtatcta tctcttccat aagcttataa ggtcacggat aatacttctc   4440

attgtagtac gtaaatgacg tgggctagat atgagttgaa taaacagtta tacctgtaaa   4500

ttcttacaga gtgaaaataa attgttatac tttacaattt gtttctctct ttagaccatt   4560

tccaggactt gtgattaata accgtgagta ttttgtgaag tgttttgttt ttgttttttc   4620

ctggggtctg acgtgtgtgc gtgtgagtgt gtatacatgc ttaacgtata tcacgttact   4680

tcacctatgt cagtaaccag gccaaatact tgttttagcc ctcagtaaaa acaccaggca   4740

cttcctagtt gtaaaattat tcaagcttct taacttccta tcctcgatgc acttaatcat   4800

aaaatggtaa taatagcacc gattttgggg gagtcgttcc agtagatgga aagcatctgg   4860

aacaggtgtc agcaagctcc tgccgacgtg tatgcataaa gttttattga aaccaccatc   4920

gtgtccattt gtttatggca gaactgagag atggcagcag caagtgtgtg cctgcaaaac   4980

ctaaaatatt tactaattgg ctctgcaaga aaagagtttg catcccccta acctagaaca   5040

gtgtctagcc tctagtatgt gtttagccta cagtatgtgc tcagcgaata caatctatat   5100

ttattactgc ttttatgact gttataatta ctgtgcttgg atttcgttac aaagtaagtc   5160

acaatgtgcc tgcttctgtt agtatttcag cacagtgcct ggcacacatg gggctctcaa   5220

atattgctga gcgagtgaac aaatgtcctt tcaattcctt aacgttgatg tcattttcaa   5280

tagtattttg agccaaactt aattttgcga gtgtgttttg ttttcttaac tttattatta   5340

aaaatgtata aaagtgaggc caggcgtggt ggctcacgcc tgtaatccca gcagtttggg   5400

aggctgaggc aggcggatca gttgaggttg ggagttggag accagcccgt ccaacatggt   5460

gaaagcctgt ctctactaaa aatacaaaaa tcagctgggt gtggtggcgc gtgcctgtaa   5520

tcccagctac tcaggaggct gaggcaggag agttgcttga atcctagagg tggaggttgc   5580

agtgagctga gatcgtgcca ttgcactcca gcctgggcaa caagagcaaa actctgtccc   5640

aataaataaa taaataaaat gttctctttt gttcctgttc ttgtgcggta gtgtggtata   5700

gagttttatg gtaattactg tgaattagtg attctgaggg acatatcaga actctgaggt   5760

ttgtttcctt ctcatcttga gggaaacagc aaatgtatgt taaaatgctt ttccaaggga   5820

acaacacatc cttacattat ttaaaccaat ctgcttcatt ttcagagctg gttgatcaga   5880

gtgagtcaga aggccccgtg atacaagaat cagctgaacc aagccagttg gaagttccag   5940

ccacagaaga aataaaagag actgatggaa gctctcagat caagcaagaa ccagacccca   6000

cgtggtagac ctcttccctc ctaggcttaa agtatcagtg gttgagaaga gcttttcgga   6060

cctgttacta ccccaagctg tgtaatatac ttgtataaca gaaatacctt ctatacaaac   6120

ctttttttct acttttagat agaaatgtct actttttcag cagttctgtg aattaaagag   6180

cagagtgact gtgggtctgg aatggctggt gtacttggga atgtactatc aggattttac   6240

agcaatgctg ggaaatgaca gggaaaatga caggaatgaa tctcaccaga ttttttatgt   6300

actcagcaga gccttgagtt acggtgttta ttttccaatc aagtgaagat atctcctact   6360

tctcctactg gaacatctca gcttctgcag tgaagaaaaa ttcctgtgat agttcagttc   6420

tttagttttt ctatttgaaa aaaaaaaatc atttaaatga tcctttgttc acggctctcc   6480

ttaatgactg agtgaacagt tcctatctgt atatttgact aaaccttttc ctaagctatc   6540

tctcatggtt cctatgtttt tttatcataa ttaaaagcaa aaccatctgg atcacctaac   6600

agtcagaggt cagtatctca gcgtgtgaat tatagaggaa atacagagag aacctcttcc   6660

acttttactt ttcgtccaaa taaaatgcat ggtgtaccag aagttgaaga tcgggttgag   6720

gattggggct agctcgatga cactaaggcc ccaacatcgc gggacctgct gtggcgcgga   6780

ttcttaggaa cgctgttcta gccggccccc tctccagggg tcgccgtggc cggcattatt   6840

tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc   6900

taaggatgca acctctgacg ttctgcgcct tcctaggaga gtcttacatg tgttgagatt   6960

tcacaagcaa tgcgagttgt aaaataccag ctctacaaga agctaggctc tgtgacggca   7020

tagttttcag tagctttatc acaatattca caatggagaa ttatatgaca tggtagcaga   7080

aataggccct tttatgtgtt gcttctattt tacctcaaat tgtagatata gggtaatcaa   7140

taaaatccat ccatgccttt cacacactaa gt                                 7172


<210>  4453
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  4453

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
465                 470                 475                 480


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
                485                 490                 495


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
            500                 505                 510


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
        515                 520                 525


Ser Ser Leu Leu Lys Asn Leu Asn 
    530                 535


<210>  4454
<211>  5018
<212>  DNA
<213>  Homo sapiens

<400>  4454
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gtcaaagaag attggaatgt   1980

cagaattacc aagctacgga agcaagtgga agagattttt aatttgaaat ttgctcaagc   2040

tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt   2100

cttgaaagga tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa acctgaacta   2160

gttatttcct acttgcctcc tgggatggct agtaaaataa acactaaagc tttgcagtcc   2220

cccaaaagac cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg   2280

gaaggcccta ataacaacaa tcctcaaacc tcagctgttc gaaccccgac ccagactaac   2340

ggttctaacg ttcccttcaa gccacgaggg agagagtttt cctttgaggc ctggaatgcc   2400

aaaatcacgg acctaaaaca gaaagttgaa aatctcttca atgagaaatg tggggaagct   2460

cttggcctta aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac   2520

ttttatgtgg aaggcttacc tgagggtgtg ccattccgaa gaccatcgac ttttggcatt   2580

ccgaggctgg agaagatact cagaaacaaa gccaaaatta agttcatcat taaaaagccc   2640

gaaatgtttg agacggcgat taaggagagc acctcctcta agagccctcc cagaaaaata   2700

aattcatcac ccaatgttaa tactactgca tcaggtgttg aagaccttaa catcattcag   2760

gtgacaattc cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta   2820

agagaacaag tgaatgacct ctttagtcgg aaatttggtg aagctattgg tatgggtttt   2880

cctgtgaaag ttccctacag gaaaatcaca attaaccctg gctgtgtggt ggttgatggc   2940

atgcccccgg gggtgtcctt caaagccccc agctacctgg aaatcagctc catgagaagg   3000

atcttagact ctgccgagtt tatcaaattc acggtcatta gaccatttcc aggacttgtg   3060

attaataacc agctggttga tcagagtgag tcagaaggcc ccgtgataca agaatcagct   3120

gaaccaagcc agttggaagt tccagccaca gaaggtaaaa ggacctcttc cctcctaggg   3180

taaatcagct tctgtgtcag ggatgctgtg tggtgtccat ctgaaccccc tgcatacgcg   3240

tagctaatgt gatctcccca ctttcacata agatggtggc cctgccttca gggaatgtgg   3300

gagccaggtg ggagccttcc cggatattta agctagaaga ttctacaggg agattctcct   3360

tggatcaata tatgtctctc agtcaaagat gtaaaagcac ttttgcctta aaaagaatgt   3420

tctgtttcta aatagagtca acgttgtcct cctcattgga attcactatg agtcagaatc   3480

attagactga cttttttttt tccatagtaa tagtattttg cagagtctca cagagctgca   3540

gatcttttgt tcatcttgca gagttaacaa gtctgatcct gttagtccag atttcttaaa   3600

tttggccaag ttataatagg agcagtagct tgagacccga agtcaggaaa ctttgacaat   3660

ggattttttt ttttaatcca gagacttgta ctggaatttg ccttaccctg tcagctcatg   3720

gacttaaggt ttcatcccgc tttatgagtg cttctgaatc caagtcattg ttacctgaat   3780

ttgcaaatta agttgtgata ttcgtgactg ttaaattcct gtaattagat taacctcttt   3840

gcttgcttgt ttgttttctc tcctatttta gcttaaagta tcagtggttg agaagagctt   3900

ttcggacctg ttactacccc aagctgtgta atatacttgt ataacagaaa taccttctat   3960

acaaaccttt ttttctactt ttagatagaa atgtctactt tttcagcagt tctgtgaatt   4020

aaagagcaga gtgactgtgg gtctggaatg gctggtgtac ttgggaatgt actatcagga   4080

ttttacagca atgctgggaa atgacaggga aaatgacagg aatgaatctc accagatttt   4140

ttatgtactc agcagagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct   4200

cctacttctc ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt   4260

cagttcttta gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg   4320

ctctccttaa tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa   4380

gctatctctc atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca   4440

cctaacagtc agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc   4500

tcttccactt ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg   4560

gttgaggatt ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg   4620

cgcggattct taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc   4680

attatttcct agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca   4740

gggggctaag gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt   4800

gagatttcac aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg   4860

acggcatagt tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt   4920

agcagaaata ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt   4980

aatcaataaa atccatccat gcctttcaca cactaagt                           5018


<210>  4455
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  4455

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys 
                565                 570                 575


Asn Leu Asn 



<210>  4456
<211>  4455
<212>  DNA
<213>  Homo sapiens

<400>  4456
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2040

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2100

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2160

tgaatcaaac ccggagttct tgaaaggatc gtccgcggga gtaataaaat caagttcgtt   2220

gttaaaaaac ctgaactagt tatttcctac ttgcctcctg ggatggctag taaaataaac   2280

actaaagctt tgcagtcccc caaaagacca cgaagtcctg ggagtaattc aaaggttcct   2340

gaaattgagg tcaccgtgga aggccctaat aacaacaatc ctcaaacctc agctgttcga   2400

accccgaccc agactaacgg ttctaacgtt cccttcaagc cacgagggag agagttttcc   2460

tttgaggcct ggaatgccaa aatcacggac ctaaaacaga aagttgaaaa tctcttcaat   2520

gagaaatgtg gggaagctct tggccttaaa caagctgtga aggtgccgtt cgcgttattt   2580

gagtctttcc cggaagactt ttatgtggaa ggcttacctg agggtgtgcc attccgaaga   2640

ccatcgactt ttggcattcc gaggctggag aagatactca gaaacaaagc caaaattaag   2700

ttcatcatta aaaagcccga aatgtttgag acggcgatta aggagagcac ctcctctaag   2760

agccctccca gaaaaataaa ttcatcaccc aatgttaata ctactgcatc aggtgttgaa   2820

gaccttaaca tcattcaggt gacaattcca gatgatgata atgaaagact ctcgaaagtt   2880

gaaaaagcta gacagctaag agaacaagtg aatgacctct ttagtcggaa atttggtgaa   2940

gctattggta tgggttttcc tgtgaaagtt ccctacagga aaatcacaat taaccctggc   3000

tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca aagcccccag ctacctggaa   3060

atcagctcca tgagaaggat cttagactct gccgagttta tcaaattcac ggtcattaga   3120

ccatttccag gacttgtgat taataaccag ctggttgatc agagtgagtc agaaggcccc   3180

gtgatacaag aatcagctga accaagccag ttggaagttc cagccacaga agaaataaaa   3240

gagactgatg gaagctctca gatcaagcaa gaaccagacc ccacgtggta gacctcttcc   3300

ctcctaggct taaagtatca gtggttgaga agagcttttc ggacctgtta ctaccccaag   3360

ctgtgtaata tacttgtata acagaaatac cttctataca aacctttttt tctactttta   3420

gatagaaatg tctacttttt cagcagttct gtgaattaaa gagcagagtg actgtgggtc   3480

tggaatggct ggtgtacttg ggaatgtact atcaggattt tacagcaatg ctgggaaatg   3540

acagggaaaa tgacaggaat gaatctcacc agatttttta tgtactcagc agagccttga   3600

gttacggtgt ttattttcca atcaagtgaa gatatctcct acttctccta ctggaacatc   3660

tcagcttctg cagtgaagaa aaattcctgt gatagttcag ttctttagtt tttctatttg   3720

aaaaaaaaaa atcatttaaa tgatcctttg ttcacggctc tccttaatga ctgagtgaac   3780

agttcctatc tgtatatttg actaaacctt ttcctaagct atctctcatg gttcctatgt   3840

ttttttatca taattaaaag caaaaccatc tggatcacct aacagtcaga ggtcagtatc   3900

tcagcgtgtg aattatagag gaaatacaga gagaacctct tccactttta cttttcgtcc   3960

aaataaaatg catggtgtac cagaagttga agatcgggtt gaggattggg gctagctcga   4020

tgacactaag gccccaacat cgcgggacct gctgtggcgc ggattcttag gaacgctgtt   4080

ctagccggcc ccctctccag gggtcgccgt ggccggcatt atttcctagt tcttcttgta   4140

accctgaggt gccagcgcgg ggagtgagga ggggtcaggg ggctaaggat gcaacctctg   4200

acgttctgcg ccttcctagg agagtcttac atgtgttgag atttcacaag caatgcgagt   4260

tgtaaaatac cagctctaca agaagctagg ctctgtgacg gcatagtttt cagtagcttt   4320

atcacaatat tcacaatgga gaattatatg acatggtagc agaaataggc ccttttatgt   4380

gttgcttcta ttttacctca aattgtagat atagggtaat caataaaatc catccatgcc   4440

tttcacacac taagt                                                    4455


<210>  4457
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  4457

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala 
            580                 585                 590


Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600                 605


<210>  4458
<211>  4294
<212>  DNA
<213>  Homo sapiens

<400>  4458
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2040

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2100

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2160

tgaatcaaac ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag   2220

ccctacctgg tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa   2280

gttcgttgtt aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa   2340

aataaacact aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa   2400

ggttcctgaa attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc   2460

tgttcgaacc ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga   2520

gttttccttt gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct   2580

cttcaatgag aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc   2640

gttatttgag tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt   2700

ccgaagacca tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa   2760

aattaagttc atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc   2820

ctctaagagc cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg   2880

tgttgaagac cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc   2940

gaaagttgaa aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt   3000

tggtgaagct attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa   3060

ccctggctgt gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta   3120

cctggaaatc agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt   3180

cattagacca tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga   3240

aggccccgtg atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga   3300

aataaaagag actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac   3360

ctcttccctc ctaggcttaa agtatcagtg gttgagaaga gcttttcgga cctgttacta   3420

ccccaagctg tagccttgag ttacggtgtt tattttccaa tcaagtgaag atatctccta   3480

cttctcctac tggaacatct cagcttctgc agtgaagaaa aattcctgtg atagttcagt   3540

tctttagttt ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt tcacggctct   3600

ccttaatgac tgagtgaaca gttcctatct gtatatttga ctaaaccttt tcctaagcta   3660

tctctcatgg ttcctatgtt tttttatcat aattaaaagc aaaaccatct ggatcaccta   3720

acagtcagag gtcagtatct cagcgtgtga attatagagg aaatacagag agaacctctt   3780

ccacttttac ttttcgtcca aataaaatgc atggtgtacc agaagttgaa gatcgggttg   3840

aggattgggg ctagctcgat gacactaagg ccccaacatc gcgggacctg ctgtggcgcg   3900

gattcttagg aacgctgttc tagccggccc cctctccagg ggtcgccgtg gccggcatta   3960

tttcctagtt cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg   4020

gctaaggatg caacctctga cgttctgcgc cttcctagga gagtcttaca tgtgttgaga   4080

tttcacaagc aatgcgagtt gtaaaatacc agctctacaa gaagctaggc tctgtgacgg   4140

catagttttc agtagcttta tcacaatatt cacaatggag aattatatga catggtagca   4200

gaaataggcc cttttatgtg ttgcttctat tttacctcaa attgtagata tagggtaatc   4260

aataaaatcc atccatgcct ttcacacact aagt                               4294


<210>  4459
<211>  978
<212>  PRT
<213>  Homo sapiens

<400>  4459

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu 
            580                 585                 590


Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg 
        595                 600                 605


Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys 
    610                 615                 620


Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys 
625                 630                 635                 640


Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly 
                645                 650                 655


Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn 
            660                 665                 670


Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn 
        675                 680                 685


Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu 
    690                 695                 700


Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu 
705                 710                 715                 720


Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys 
                725                 730                 735


Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu 
            740                 745                 750


Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile 
        755                 760                 765


Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile 
    770                 775                 780


Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser 
785                 790                 795                 800


Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr 
                805                 810                 815


Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro 
            820                 825                 830


Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu 
        835                 840                 845


Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile 
    850                 855                 860


Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn 
865                 870                 875                 880


Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys 
                885                 890                 895


Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser 
            900                 905                 910


Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val 
        915                 920                 925


Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile 
    930                 935                 940


Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu 
945                 950                 955                 960


Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro 
                965                 970                 975


Thr Trp 



<210>  4460
<211>  4146
<212>  DNA
<213>  Homo sapiens

<400>  4460
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagc tcaagctctt ggactcaccg   2040

aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag   2100

gcttgccaga ggggattccc ttccgaagcc ctacctggtt tggaattcca cgacttgaaa   2160

ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt   2220

cctacttgcc tcctgggatg gctagtaaaa taaacactaa agctttgcag tcccccaaaa   2280

gaccacgaag tcctgggagt aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc   2340

ctaataacaa caatcctcaa acctcagctg ttcgaacccc gacccagact aacggttcta   2400

acgttccctt caagccacga gggagagagt tttcctttga ggcctggaat gccaaaatca   2460

cggacctaaa acagaaagtt gaaaatctct tcaatgagaa atgtggggaa gctcttggcc   2520

ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc tttcccggaa gacttttatg   2580

tggaaggctt acctgagggt gtgccattcc gaagaccatc gacttttggc attccgaggc   2640

tggagaagat actcagaaac aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt   2700

ttgagacggc gattaaggag agcacctcct ctaagagccc tcccagaaaa ataaattcat   2760

cacccaatgt taatactact gcatcaggtg ttgaagacct taacatcatt caggtgacaa   2820

ttccagatga tgataatgaa agactctcga aagttgaaaa agctagacag ctaagagaac   2880

aagtgaatga cctctttagt cggaaatttg gtgaagctat tggtatgggt tttcctgtga   2940

aagttcccta caggaaaatc acaattaacc ctggctgtgt ggtggttgat ggcatgcccc   3000

cgggggtgtc cttcaaagcc cccagctacc tggaaatcag ctccatgaga aggatcttag   3060

actctgccga gtttatcaaa ttcacggtca ttagaccatt tccaggactt gtgattaata   3120

accagctggt tgatcagagt gagtcagaag gccccgtgat acaagaatca gctgaaccaa   3180

gccagttgga agttccagcc acagaagaaa taaaagagac tgatggaagc tctcagatca   3240

agcaagaacc agaccccacg tggtagacct cttccctcct aggagccttg agttacggtg   3300

tttattttcc aatcaagtga agatatctcc tacttctcct actggaacat ctcagcttct   3360

gcagtgaaga aaaattcctg tgatagttca gttctttagt ttttctattt gaaaaaaaaa   3420

aatcatttaa atgatccttt gttcacggct ctccttaatg actgagtgaa cagttcctat   3480

ctgtatattt gactaaacct tttcctaagc tatctctcat ggttcctatg tttttttatc   3540

ataattaaaa gcaaaaccat ctggatcacc taacagtcag aggtcagtat ctcagcgtgt   3600

gaattataga ggaaatacag agagaacctc ttccactttt acttttcgtc caaataaaat   3660

gcatggtgta ccagaagttg aagatcgggt tgaggattgg ggctagctcg atgacactaa   3720

ggccccaaca tcgcgggacc tgctgtggcg cggattctta ggaacgctgt tctagccggc   3780

cccctctcca ggggtcgccg tggccggcat tatttcctag ttcttcttgt aaccctgagg   3840

tgccagcgcg gggagtgagg aggggtcagg gggctaagga tgcaacctct gacgttctgc   3900

gccttcctag gagagtctta catgtgttga gatttcacaa gcaatgcgag ttgtaaaata   3960

ccagctctac aagaagctag gctctgtgac ggcatagttt tcagtagctt tatcacaata   4020

ttcacaatgg agaattatat gacatggtag cagaaatagg cccttttatg tgttgcttct   4080

attttacctc aaattgtaga tatagggtaa tcaataaaat ccatccatgc ctttcacaca   4140

ctaagt                                                              4146


<210>  4461
<211>  954
<212>  PRT
<213>  Homo sapiens

<400>  4461

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly 
    530                 535                 540


Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro 
545                 550                 555                 560


Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser 
                565                 570                 575


Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser 
            580                 585                 590


Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr 
        595                 600                 605


Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser 
    610                 615                 620


Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile 
625                 630                 635                 640


Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala 
                645                 650                 655


Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro 
            660                 665                 670


Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp 
        675                 680                 685


Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala 
    690                 695                 700


Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser 
705                 710                 715                 720


Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe 
                725                 730                 735


Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg 
            740                 745                 750


Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu 
        755                 760                 765


Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile 
    770                 775                 780


Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu 
785                 790                 795                 800


Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser 
                805                 810                 815


Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe 
            820                 825                 830


Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val 
        835                 840                 845


Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly 
    850                 855                 860


Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser 
865                 870                 875                 880


Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val 
                885                 890                 895


Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln 
            900                 905                 910


Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln 
        915                 920                 925


Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser 
    930                 935                 940


Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  4462
<211>  3859
<212>  DNA
<213>  Homo sapiens

<400>  4462
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   2040

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2100

taccatatcc tgtgtttgaa tcaaacccgg agttcttgaa aggatcgtcc gcgggagtaa   2160

taaaatcaag ttcgttgtta aaaaacctga actagttatt tcctacttgc ctcctgggat   2220

ggctagtaaa ataaacacta aagctttgca gtcccccaaa agaccacgaa gtcctgggag   2280

taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc cctaataaca acaatcctca   2340

aacctcagct gttcgaaccc cgacccagac taacggttct aacgttccct tcaagccacg   2400

agggagagag ttttcctttg aggcctggaa tgccaaaatc acggacctaa aacagaaagt   2460

tgaaaatctc ttcaatgaga aatgtgggga agctcttggc cttaaacaag ctgtgaaggt   2520

gccgttcgcg ttatttgagt ctttcccgga agacttttat gtggaaggct tacctgaggg   2580

tgtgccattc cgaagaccat cgacttttgg cattccgagg ctggagaaga tactcagaaa   2640

caaagccaaa attaagttca tcattaaaaa gcccgaaatg tttgagacgg cgattaagga   2700

gagcacctcc tctaagagcc ctcccagaaa aataaattca tcacccaatg ttaatactac   2760

tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca attccagatg atgataatga   2820

aagactctcg aaagttgaaa aagctagaca gctaagagaa caagtgaatg acctctttag   2880

tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg aaagttccct acaggaaaat   2940

cacaattaac cctggctgtg tggtggttga tggcatgccc ccgggggtgt ccttcaaagc   3000

ccccagctac ctggaaatca gctccatgag aaggatctta gactctgccg agtttatcaa   3060

attcacggtc attagaccat ttccaggact tgtgattaat aaccagctgg ttgatcagag   3120

tgagtcagaa ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc   3180

cacagaagaa ataaaagaga ctgatggaag ctctcagatc aagcaagaac cagaccccac   3240

gtggtagacc tcttccctcc taggcaaaac catctggatc acctaacagt cagaggtcag   3300

tatctcagcg tgtgaattat agaggaaata cagagagaac ctcttccact tttacttttc   3360

gtccaaataa aatgcatggt gtaccagaag ttgaagatcg ggttgaggat tggggctagc   3420

tcgatgacac taaggcccca acatcgcggg acctgctgtg gcgcggattc ttaggaacgc   3480

tgttctagcc ggccccctct ccaggggtcg ccgtggccgg cattatttcc tagttcttct   3540

tgtaaccctg aggtgccagc gcggggagtg aggaggggtc agggggctaa ggatgcaacc   3600

tctgacgttc tgcgccttcc taggagagtc ttacatgtgt tgagatttca caagcaatgc   3660

gagttgtaaa ataccagctc tacaagaagc taggctctgt gacggcatag ttttcagtag   3720

ctttatcaca atattcacaa tggagaatta tatgacatgg tagcagaaat aggccctttt   3780

atgtgttgct tctattttac ctcaaattgt agatataggg taatcaataa aatccatcca   3840

tgcctttcac acactaagt                                                3859


<210>  4463
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  4463

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
465                 470                 475                 480


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
                485                 490                 495


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
            500                 505                 510


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
        515                 520                 525


Ser Ser Leu Leu Lys Asn Leu Asn 
    530                 535


<210>  4464
<211>  8004
<212>  DNA
<213>  Homo sapiens

<400>  4464
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1980

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct tagatttgtt   2040

gacagcggtt tcctggagtg ctgtcttgag aacgattctg aggaggctca gcaagaaaga   2100

gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa ctcaagctct tggactcacc   2160

gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc cggagttctt gtatgtggaa   2220

ggcttgccag aggggattcc cttccgaagc cctacctggt ttggaattcc acgacttgaa   2280

aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta aaaaacctga actagttatt   2340

tcctacttgc ctcctgggat ggctagtaaa ataaacacta aagctttgca gtcccccaaa   2400

agaccacgaa gtcctgggag taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc   2460

cctaataaca acaatcctca aacctcagct gttcgaaccc cgacccagac taacggttct   2520

aacgttccct tcaagccacg agggagagag ttttcctttg aggcctggaa tgccaaaatc   2580

acggacctaa aacagaaagt tgaaaatctc ttcaatgaga aatgtgggga agctcttggc   2640

cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt ctttcccgga agacttttat   2700

gtggaaggct tacctgaggg tgtgccattc cgaagaccat cgacttttgg cattccgagg   2760

ctggagaaga tactcagaaa caaagccaaa attaagttca tcattaaaaa gcccgaaatg   2820

tttgagacgg cgattaagga gagcacctcc tctaagagcc ctcccagaaa aataaattca   2880

tcacccaatg ttaatactac tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca   2940

attccagatg atgataatga aagactctcg aaagttgaaa aagctagaca gctaagagaa   3000

caagtgaatg acctctttag tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg   3060

aaagttccct acaggaaaat cacaattaac cctggctgtg tggtggttga tggcatgccc   3120

ccgggggtgt ccttcaaagc ccccagctac ctggaaatca gctccatgag aaggatctta   3180

gactctgccg agtttatcaa attcacggtc attaggtaag tgagagtttc ctgcttagtc   3240

acaggagcga atctggagct catgaggctg actcttctaa aatgcagcca caggtagtca   3300

tcgaatccgg cttcctatgc tgtgcaatca acaaatcaaa ataacttgtg tcatcattag   3360

aatgtcagat gtgcttctac gaactaagct gactctttta attctttggc aaagggttgg   3420

caaactagga ctgtttgcca aattcaggct gcctcctatt tttagagtct tcctgaaaca   3480

cagctacacc cgtattatcc atggctgctt tcctgtcaca gtgagtaagt agctgggact   3540

gagaaggcat ggcctccaaa gtctaaaata tttactctct agcactttgt agaaaaacct   3600

tagctaggca cagtggctaa cgcctgtaat cccagcattt tgggaggcca aggcaggcag   3660

atcacctgag gtcaggagtt ccagaccagc ctggccaaca tggtgaaatc ccatctctac   3720

aaaaataaaa cagttagctg ggcatgatgg cgggtgcctg taatcccagc tactcgggag   3780

gctgaggcag gatagtcgct tgaacccagg aggtggaggt tgcaatgagc caagatcatg   3840

ccactgcact ccagcctgga cgacagagtg agactccatc acaagaaaaa aagaactttg   3900

tcaacctctg tcttagggcg ccttgtcaca ggcttcgggt cagacggatt caaccttgca   3960

tcagccattt gttagccagg tcactctgtt ctttgtctgt aaatgagatt gatcgttgtt   4020

cccactgaga gtgtcagctc cttcccgtag agcaggcatg atgattgtac tcacctctga   4080

caccattgtg agtgccacat tccttcccac gtccttgtca ctgtaagaga tgcccacctg   4140

agcaccaacc ccaggttatc ttcccctttg tcttccagcc ccccagaaac agctacgact   4200

caacctaccc aatcatttca tcatcagatt gccactgtct ctagttcagg tctcttggga   4260

ctggcactca gaaatctcat aataaatcct cttgaggctt ctcatacact cgtcttcttc   4320

caatcttctt tccctcaaaa tctcatattt tggttccact tcacccaccg tcattctcca   4380

tatcactccc aggagttagg caaaaagccc cttccgttct tccgtatgtt aaacttagaa   4440

tcactctgtt ccctgctctg cgtttctatt ttttgttttt cctccattta ctagtagctt   4500

aacactttct aacagtgttc ttattattga tacgtatcta tctcttccat aagcttataa   4560

ggtcacggat aatacttctc attgtagtac gtaaatgacg tgggctagat atgagttgaa   4620

taaacagtta tacctgtaaa ttcttacaga gtgaaaataa attgttatac tttacaattt   4680

gtttctctct ttagaccatt tccaggactt gtgattaata accgtgagta ttttgtgaag   4740

tgttttgttt ttgttttttc ctggggtctg acgtgtgtgc gtgtgagtgt gtatacatgc   4800

ttaacgtata tcacgttact tcacctatgt cagtaaccag gccaaatact tgttttagcc   4860

ctcagtaaaa acaccaggca cttcctagtt gtaaaattat tcaagcttct taacttccta   4920

tcctcgatgc acttaatcat aaaatggtaa taatagcacc gattttgggg gagtcgttcc   4980

agtagatgga aagcatctgg aacaggtgtc agcaagctcc tgccgacgtg tatgcataaa   5040

gttttattga aaccaccatc gtgtccattt gtttatggca gaactgagag atggcagcag   5100

caagtgtgtg cctgcaaaac ctaaaatatt tactaattgg ctctgcaaga aaagagtttg   5160

catcccccta acctagaaca gtgtctagcc tctagtatgt gtttagccta cagtatgtgc   5220

tcagcgaata caatctatat ttattactgc ttttatgact gttataatta ctgtgcttgg   5280

atttcgttac aaagtaagtc acaatgtgcc tgcttctgtt agtatttcag cacagtgcct   5340

ggcacacatg gggctctcaa atattgctga gcgagtgaac aaatgtcctt tcaattcctt   5400

aacgttgatg tcattttcaa tagtattttg agccaaactt aattttgcga gtgtgttttg   5460

ttttcttaac tttattatta aaaatgtata aaagtgaggc caggcgtggt ggctcacgcc   5520

tgtaatccca gcagtttggg aggctgaggc aggcggatca gttgaggttg ggagttggag   5580

accagcccgt ccaacatggt gaaagcctgt ctctactaaa aatacaaaaa tcagctgggt   5640

gtggtggcgc gtgcctgtaa tcccagctac tcaggaggct gaggcaggag agttgcttga   5700

atcctagagg tggaggttgc agtgagctga gatcgtgcca ttgcactcca gcctgggcaa   5760

caagagcaaa actctgtccc aataaataaa taaataaaat gttctctttt gttcctgttc   5820

ttgtgcggta gtgtggtata gagttttatg gtaattactg tgaattagtg attctgaggg   5880

acatatcaga actctgaggt ttgtttcctt ctcatcttga gggaaacagc aaatgtatgt   5940

taaaatgctt ttccaaggga acaacacatc cttacattat ttaaaccaat ctgcttcatt   6000

ttcagagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat cagctgaacc   6060

aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa gctctcagat   6120

caagcaagaa ccagacccca cgtggtagac ctcttccctc ctagggtaaa tcagcttctg   6180

tgtcagggat gctgtgtggt gtccatctga accccctgca tacgcgtagc taatgtgatc   6240

tccccacttt cacataagat ggtggccctg ccttcaggga atgtgggagc caggtgggag   6300

ccttcccgga tatttaagct agaagattct acagggagat tctccttgga tcaatatatg   6360

tctctcagtc aaagatgtaa aagcactttt gccttaaaaa gaatgttctg tttctaaata   6420

gagtcaacgt tgtcctcctc attggaattc actatgagtc agaatcatta gactgacttt   6480

tttttttcca tagtaatagt attttgcaga gtctcacaga gctgcagatc ttttgttcat   6540

cttgcagagt taacaagtct gatcctgtta gtccagattt cttaaatttg gccaagttat   6600

aataggagca gtagcttgag acccgaagtc aggaaacttt gacaatggat tttttttttt   6660

aatccagaga cttgtactgg aatttgcctt accctgtcag ctcatggact taaggtttca   6720

tcccgcttta tgagtgcttc tgaatccaag tcattgttac ctgaatttgc aaattaagtt   6780

gtgatattcg tgactgttaa attcctgtaa ttagattaac ctctttgctt gcttgtttgt   6840

tttctctcct attttagctt aaagtatcag tggttgagaa gagcttttcg gacctgttac   6900

taccccaagc tgtgtaatat acttgtataa cagaaatacc ttctatacaa accttttttt   6960

ctacttttag atagaaatgt ctactttttc agcagttctg tgaattaaag agcagagtga   7020

ctgtgggtct ggaatggctg gtgtacttgg gaatgtacta tcaggatttt acagcaatgc   7080

tgggaaatga cagggaaaat gacaggaatg aatctcacca gattttttat gtactcagca   7140

gagccttgag ttacggtgtt tattttccaa tcaagtgaag atatctccta cttctcctac   7200

tggaacatct cagcttctgc agtgaagaaa aattcctgtg atagttcagt tctttagttt   7260

ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt tcacggctct ccttaatgac   7320

tgagtgaaca gttcctatct gtatatttga ctaaaccttt tcctaagcta tctctcatgg   7380

ttcctatgtt tttttatcat aattaaaagc aaaaccatct ggatcaccta acagtcagag   7440

gtcagtatct cagcgtgtga attatagagg aaatacagag agaacctctt ccacttttac   7500

ttttcgtcca aataaaatgc atggtgtacc agaagttgaa gatcgggttg aggattgggg   7560

ctagctcgat gacactaagg ccccaacatc gcgggacctg ctgtggcgcg gattcttagg   7620

aacgctgttc tagccggccc cctctccagg ggtcgccgtg gccggcatta tttcctagtt   7680

cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg gctaaggatg   7740

caacctctga cgttctgcgc cttcctagga gagtcttaca tgtgttgaga tttcacaagc   7800

aatgcgagtt gtaaaatacc agctctacaa gaagctaggc tctgtgacgg catagttttc   7860

agtagcttta tcacaatatt cacaatggag aattatatga catggtagca gaaataggcc   7920

cttttatgtg ttgcttctat tttacctcaa attgtagata tagggtaatc aataaaatcc   7980

atccatgcct ttcacacact aagt                                          8004


<210>  4465
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  4465

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  4466
<211>  4367
<212>  DNA
<213>  Homo sapiens

<400>  4466
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagctca agctcttgga ctcaccgagg   1980

cagtaaaagt accatatcct gtgtttgaat caaacccgga gttcttgtat gtggaaggct   2040

tgccagaggg gattcccttc cgaagcccta cctggtttgg aattccacga cttgaaagga   2100

tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa acctgaacta gttatttcct   2160

acttgcctcc tgggatggct agtaaaataa acactaaagc tttgcagtcc cccaaaagac   2220

cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta   2280

ataacaacaa tcctcaaacc tcagctgttc gaaccccgac ccagactaac ggttctaacg   2340

ttcccttcaa gccacgaggg agagagtttt cctttgaggc ctggaatgcc aaaatcacgg   2400

acctaaaaca gaaagttgaa aatctcttca atgagaaatg tggggaagct cttggcctta   2460

aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg   2520

aaggcttacc tgagggtgtg ccattccgaa gaccatcgac ttttggcatt ccgaggctgg   2580

agaagatact cagaaacaaa gccaaaatta agttcatcat taaaaagccc gaaatgtttg   2640

agacggcgat taaggagagc acctcctcta agagccctcc cagaaaaata aattcatcac   2700

ccaatgttaa tactactgca tcaggtgttg aagaccttaa catcattcag gtgacaattc   2760

cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta agagaacaag   2820

tgaatgacct ctttagtcgg aaatttggtg aagctattgg tatgggtttt cctgtgaaag   2880

ttccctacag gaaaatcaca attaaccctg gctgtgtggt ggttgatggc atgcccccgg   2940

gggtgtcctt caaagccccc agctacctgg aaatcagctc catgagaagg atcttagact   3000

ctgccgagtt tatcaaattc acggtcatta gaccatttcc aggacttgtg attaataacc   3060

agctggttga tcagagtgag tcagaaggcc ccgtgataca agaatcagct gaaccaagcc   3120

agttggaagt tccagccaca gaagaaataa aagagactga tggaagctct cagatcaagc   3180

aagaaccaga ccccacgtgg tagacctctt ccctcctagg cttaaagtat cagtggttga   3240

gaagagcttt tcggacctgt tactacccca agctgtgtaa tatacttgta taacagaaat   3300

accttctata caaacctttt tttctacttt tagatagaaa tgtctacttt ttcagcagtt   3360

ctgtgaatta aagagcagag tgactgtggg tctggaatgg ctggtgtact tgggaatgta   3420

ctatcaggat tttacagcaa tgctgggaaa tgacagggaa aatgacagga atgaatctca   3480

ccagattttt tatgtactca gcagagcctt gagttacggt gtttattttc caatcaagtg   3540

aagatatctc ctacttctcc tactggaaca tctcagcttc tgcagtgaag aaaaattcct   3600

gtgatagttc agttctttag tttttctatt tgaaaaaaaa aaatcattta aatgatcctt   3660

tgttcacggc tctccttaat gactgagtga acagttccta tctgtatatt tgactaaacc   3720

ttttcctaag ctatctctca tggttcctat gtttttttat cataattaaa agcaaaacca   3780

tctggatcac ctaacagtca gaggtcagta tctcagcgtg tgaattatag aggaaataca   3840

gagagaacct cttccacttt tacttttcgt ccaaataaaa tgcatggtgt accagaagtt   3900

gaagatcggg ttgaggattg gggctagctc gatgacacta aggccccaac atcgcgggac   3960

ctgctgtggc gcggattctt aggaacgctg ttctagccgg ccccctctcc aggggtcgcc   4020

gtggccggca ttatttccta gttcttcttg taaccctgag gtgccagcgc ggggagtgag   4080

gaggggtcag ggggctaagg atgcaacctc tgacgttctg cgccttccta ggagagtctt   4140

acatgtgttg agatttcaca agcaatgcga gttgtaaaat accagctcta caagaagcta   4200

ggctctgtga cggcatagtt ttcagtagct ttatcacaat attcacaatg gagaattata   4260

tgacatggta gcagaaatag gcccttttat gtgttgcttc tattttacct caaattgtag   4320

atatagggta atcaataaaa tccatccatg cctttcacac actaagt                 4367


<210>  4467
<211>  933
<212>  PRT
<213>  Homo sapiens

<400>  4467

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
        515                 520                 525


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
    530                 535                 540


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
545                 550                 555                 560


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
                565                 570                 575


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
            580                 585                 590


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
        595                 600                 605


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
    610                 615                 620


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
625                 630                 635                 640


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
                645                 650                 655


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
            660                 665                 670


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
        675                 680                 685


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
    690                 695                 700


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
705                 710                 715                 720


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
                725                 730                 735


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
            740                 745                 750


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
        755                 760                 765


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
    770                 775                 780


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
785                 790                 795                 800


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
                805                 810                 815


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
            820                 825                 830


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
        835                 840                 845


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
    850                 855                 860


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro 
865                 870                 875                 880


Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly 
                885                 890                 895


Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala 
            900                 905                 910


Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu 
        915                 920                 925


Pro Asp Pro Thr Trp 
    930


<210>  4468
<211>  4118
<212>  DNA
<213>  Homo sapiens

<400>  4468
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   1980

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   2040

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2100

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2160

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2220

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2280

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2340

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2400

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2460

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2520

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2580

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2640

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2700

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2760

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2820

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2880

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   2940

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   3000

cggtcattag accatttcca ggacttgtga ttaataacca gctggttgat cagagtgagt   3060

cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt ccagccacag   3120

aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac cccacgtggt   3180

agacctcttc cctcctaggc ttaaagtatc agtggttgag aagagctttt cggacctgtt   3240

actaccccaa gctgtagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct   3300

cctacttctc ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt   3360

cagttcttta gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg   3420

ctctccttaa tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa   3480

gctatctctc atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca   3540

cctaacagtc agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc   3600

tcttccactt ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg   3660

gttgaggatt ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg   3720

cgcggattct taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc   3780

attatttcct agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca   3840

gggggctaag gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt   3900

gagatttcac aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg   3960

acggcatagt tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt   4020

agcagaaata ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt   4080

aatcaataaa atccatccat gcctttcaca cactaagt                           4118


<210>  4469
<211>  865
<212>  PRT
<213>  Homo sapiens

<400>  4469

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
    450                 455                 460


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
465                 470                 475                 480


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
                485                 490                 495


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
            500                 505                 510


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
        515                 520                 525


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
    530                 535                 540


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
545                 550                 555                 560


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
                565                 570                 575


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
            580                 585                 590


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
        595                 600                 605


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
    610                 615                 620


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
625                 630                 635                 640


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
                645                 650                 655


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
            660                 665                 670


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
        675                 680                 685


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
    690                 695                 700


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
705                 710                 715                 720


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
                725                 730                 735


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
            740                 745                 750


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
        755                 760                 765


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
    770                 775                 780


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
785                 790                 795                 800


Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile 
                805                 810                 815


Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln 
            820                 825                 830


Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile 
        835                 840                 845


Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr 
    850                 855                 860


Trp 
865


<210>  4470
<211>  7864
<212>  DNA
<213>  Homo sapiens

<400>  4470
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   2040

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2100

taccatatcc tgtgtttgaa tcaaacccgg agttcttgaa aggatcgtcc gcgggagtaa   2160

taaaatcaag ttcgttgtta aaaaacctga actagttatt tcctacttgc ctcctgggat   2220

ggctagtaaa ataaacacta aagctttgca gtcccccaaa agaccacgaa gtcctgggag   2280

taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc cctaataaca acaatcctca   2340

aacctcagct gttcgaaccc cgacccagac taacggttct aacgttccct tcaagccacg   2400

agggagagag ttttcctttg aggcctggaa tgccaaaatc acggacctaa aacagaaagt   2460

tgaaaatctc ttcaatgaga aatgtgggga agctcttggc cttaaacaag ctgtgaaggt   2520

gccgttcgcg ttatttgagt ctttcccgga agacttttat gtggaaggct tacctgaggg   2580

tgtgccattc cgaagaccat cgacttttgg cattccgagg ctggagaaga tactcagaaa   2640

caaagccaaa attaagttca tcattaaaaa gcccgaaatg tttgagacgg cgattaagga   2700

gagcacctcc tctaagagcc ctcccagaaa aataaattca tcacccaatg ttaatactac   2760

tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca attccagatg atgataatga   2820

aagactctcg aaagttgaaa aagctagaca gctaagagaa caagtgaatg acctctttag   2880

tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg aaagttccct acaggaaaat   2940

cacaattaac cctggctgtg tggtggttga tggcatgccc ccgggggtgt ccttcaaagc   3000

ccccagctac ctggaaatca gctccatgag aaggatctta gactctgccg agtttatcaa   3060

attcacggtc attaggtaag tgagagtttc ctgcttagtc acaggagcga atctggagct   3120

catgaggctg actcttctaa aatgcagcca caggtagtca tcgaatccgg cttcctatgc   3180

tgtgcaatca acaaatcaaa ataacttgtg tcatcattag aatgtcagat gtgcttctac   3240

gaactaagct gactctttta attctttggc aaagggttgg caaactagga ctgtttgcca   3300

aattcaggct gcctcctatt tttagagtct tcctgaaaca cagctacacc cgtattatcc   3360

atggctgctt tcctgtcaca gtgagtaagt agctgggact gagaaggcat ggcctccaaa   3420

gtctaaaata tttactctct agcactttgt agaaaaacct tagctaggca cagtggctaa   3480

cgcctgtaat cccagcattt tgggaggcca aggcaggcag atcacctgag gtcaggagtt   3540

ccagaccagc ctggccaaca tggtgaaatc ccatctctac aaaaataaaa cagttagctg   3600

ggcatgatgg cgggtgcctg taatcccagc tactcgggag gctgaggcag gatagtcgct   3660

tgaacccagg aggtggaggt tgcaatgagc caagatcatg ccactgcact ccagcctgga   3720

cgacagagtg agactccatc acaagaaaaa aagaactttg tcaacctctg tcttagggcg   3780

ccttgtcaca ggcttcgggt cagacggatt caaccttgca tcagccattt gttagccagg   3840

tcactctgtt ctttgtctgt aaatgagatt gatcgttgtt cccactgaga gtgtcagctc   3900

cttcccgtag agcaggcatg atgattgtac tcacctctga caccattgtg agtgccacat   3960

tccttcccac gtccttgtca ctgtaagaga tgcccacctg agcaccaacc ccaggttatc   4020

ttcccctttg tcttccagcc ccccagaaac agctacgact caacctaccc aatcatttca   4080

tcatcagatt gccactgtct ctagttcagg tctcttggga ctggcactca gaaatctcat   4140

aataaatcct cttgaggctt ctcatacact cgtcttcttc caatcttctt tccctcaaaa   4200

tctcatattt tggttccact tcacccaccg tcattctcca tatcactccc aggagttagg   4260

caaaaagccc cttccgttct tccgtatgtt aaacttagaa tcactctgtt ccctgctctg   4320

cgtttctatt ttttgttttt cctccattta ctagtagctt aacactttct aacagtgttc   4380

ttattattga tacgtatcta tctcttccat aagcttataa ggtcacggat aatacttctc   4440

attgtagtac gtaaatgacg tgggctagat atgagttgaa taaacagtta tacctgtaaa   4500

ttcttacaga gtgaaaataa attgttatac tttacaattt gtttctctct ttagaccatt   4560

tccaggactt gtgattaata accgtgagta ttttgtgaag tgttttgttt ttgttttttc   4620

ctggggtctg acgtgtgtgc gtgtgagtgt gtatacatgc ttaacgtata tcacgttact   4680

tcacctatgt cagtaaccag gccaaatact tgttttagcc ctcagtaaaa acaccaggca   4740

cttcctagtt gtaaaattat tcaagcttct taacttccta tcctcgatgc acttaatcat   4800

aaaatggtaa taatagcacc gattttgggg gagtcgttcc agtagatgga aagcatctgg   4860

aacaggtgtc agcaagctcc tgccgacgtg tatgcataaa gttttattga aaccaccatc   4920

gtgtccattt gtttatggca gaactgagag atggcagcag caagtgtgtg cctgcaaaac   4980

ctaaaatatt tactaattgg ctctgcaaga aaagagtttg catcccccta acctagaaca   5040

gtgtctagcc tctagtatgt gtttagccta cagtatgtgc tcagcgaata caatctatat   5100

ttattactgc ttttatgact gttataatta ctgtgcttgg atttcgttac aaagtaagtc   5160

acaatgtgcc tgcttctgtt agtatttcag cacagtgcct ggcacacatg gggctctcaa   5220

atattgctga gcgagtgaac aaatgtcctt tcaattcctt aacgttgatg tcattttcaa   5280

tagtattttg agccaaactt aattttgcga gtgtgttttg ttttcttaac tttattatta   5340

aaaatgtata aaagtgaggc caggcgtggt ggctcacgcc tgtaatccca gcagtttggg   5400

aggctgaggc aggcggatca gttgaggttg ggagttggag accagcccgt ccaacatggt   5460

gaaagcctgt ctctactaaa aatacaaaaa tcagctgggt gtggtggcgc gtgcctgtaa   5520

tcccagctac tcaggaggct gaggcaggag agttgcttga atcctagagg tggaggttgc   5580

agtgagctga gatcgtgcca ttgcactcca gcctgggcaa caagagcaaa actctgtccc   5640

aataaataaa taaataaaat gttctctttt gttcctgttc ttgtgcggta gtgtggtata   5700

gagttttatg gtaattactg tgaattagtg attctgaggg acatatcaga actctgaggt   5760

ttgtttcctt ctcatcttga gggaaacagc aaatgtatgt taaaatgctt ttccaaggga   5820

acaacacatc cttacattat ttaaaccaat ctgcttcatt ttcagagctg gttgatcaga   5880

gtgagtcaga aggccccgtg atacaagaat cagctgaacc aagccagttg gaagttccag   5940

ccacagaaga aataaaagag actgatggaa gctctcagat caagcaagaa ccagacccca   6000

cgtggtagac ctcttccctc ctagggtaaa tcagcttctg tgtcagggat gctgtgtggt   6060

gtccatctga accccctgca tacgcgtagc taatgtgatc tccccacttt cacataagat   6120

ggtggccctg ccttcaggga atgtgggagc caggtgggag ccttcccgga tatttaagct   6180

agaagattct acagggagat tctccttgga tcaatatatg tctctcagtc aaagatgtaa   6240

aagcactttt gccttaaaaa gaatgttctg tttctaaata gagtcaacgt tgtcctcctc   6300

attggaattc actatgagtc agaatcatta gactgacttt tttttttcca tagtaatagt   6360

attttgcaga gtctcacaga gctgcagatc ttttgttcat cttgcagagt taacaagtct   6420

gatcctgtta gtccagattt cttaaatttg gccaagttat aataggagca gtagcttgag   6480

acccgaagtc aggaaacttt gacaatggat tttttttttt aatccagaga cttgtactgg   6540

aatttgcctt accctgtcag ctcatggact taaggtttca tcccgcttta tgagtgcttc   6600

tgaatccaag tcattgttac ctgaatttgc aaattaagtt gtgatattcg tgactgttaa   6660

attcctgtaa ttagattaac ctctttgctt gcttgtttgt tttctctcct attttagctt   6720

aaagtatcag tggttgagaa gagcttttcg gacctgttac taccccaagc tgtgtaatat   6780

acttgtataa cagaaatacc ttctatacaa accttttttt ctacttttag atagaaatgt   6840

ctactttttc agcagttctg tgaattaaag agcagagtga ctgtgggtct ggaatggctg   6900

gtgtacttgg gaatgtacta tcaggatttt acagcaatgc tgggaaatga cagggaaaat   6960

gacaggaatg aatctcacca gattttttat gtactcagca gagccttgag ttacggtgtt   7020

tattttccaa tcaagtgaag atatctccta cttctcctac tggaacatct cagcttctgc   7080

agtgaagaaa aattcctgtg atagttcagt tctttagttt ttctatttga aaaaaaaaaa   7140

tcatttaaat gatcctttgt tcacggctct ccttaatgac tgagtgaaca gttcctatct   7200

gtatatttga ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt tttttatcat   7260

aattaaaagc aaaaccatct ggatcaccta acagtcagag gtcagtatct cagcgtgtga   7320

attatagagg aaatacagag agaacctctt ccacttttac ttttcgtcca aataaaatgc   7380

atggtgtacc agaagttgaa gatcgggttg aggattgggg ctagctcgat gacactaagg   7440

ccccaacatc gcgggacctg ctgtggcgcg gattcttagg aacgctgttc tagccggccc   7500

cctctccagg ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa ccctgaggtg   7560

ccagcgcggg gagtgaggag gggtcagggg gctaaggatg caacctctga cgttctgcgc   7620

cttcctagga gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc   7680

agctctacaa gaagctaggc tctgtgacgg catagttttc agtagcttta tcacaatatt   7740

cacaatggag aattatatga catggtagca gaaataggcc cttttatgtg ttgcttctat   7800

tttacctcaa attgtagata tagggtaatc aataaaatcc atccatgcct ttcacacact   7860

aagt                                                                7864


<210>  4471
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  4471

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
465                 470                 475                 480


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
                485                 490                 495


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
            500                 505                 510


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
        515                 520                 525


Ser Ser Leu Leu Lys Asn Leu Asn 
    530                 535


<210>  4472
<211>  4183
<212>  DNA
<213>  Homo sapiens

<400>  4472
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   2040

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2100

taccatatcc tgtgtttgaa tcaaacccgg agttcttgaa aggatcgtcc gcgggagtaa   2160

taaaatcaag ttcgttgtta aaaaacctga actagttatt tcctacttgc ctcctgggat   2220

ggctagtaaa ataaacacta aagctttgca gtcccccaaa agaccacgaa gtcctgggag   2280

taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc cctaataaca acaatcctca   2340

aacctcagct gttcgaaccc cgacccagac taacggttct aacgttccct tcaagccacg   2400

agggagagag ttttcctttg aggcctggaa tgccaaaatc acggacctaa aacagaaagt   2460

tgaaaatctc ttcaatgaga aatgtgggga agctcttggc cttaaacaag ctgtgaaggt   2520

gccgttcgcg ttatttgagt ctttcccgga agacttttat gtggaaggct tacctgaggg   2580

tgtgccattc cgaagaccat cgacttttgg cattccgagg ctggagaaga tactcagaaa   2640

caaagccaaa attaagttca tcattaaaaa gcccgaaatg tttgagacgg cgattaagga   2700

gagcacctcc tctaagagcc ctcccagaaa aataaattca tcacccaatg ttaatactac   2760

tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca attccagatg atgataatga   2820

aagactctcg aaagttgaaa aagctagaca gctaagagaa caagtgaatg acctctttag   2880

tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg aaagttccct acaggaaaat   2940

cacaattaac cctggctgtg tggtggttga tggcatgccc ccgggggtgt ccttcaaagc   3000

ccccagctac ctggaaatca gctccatgag aaggatctta gactctgccg agtttatcaa   3060

attcacggtc attagaccat ttccaggact tgtgattaat aaccagctgg ttgatcagag   3120

tgagtcagaa ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc   3180

cacagaagaa ataaaagaga ctgatggaag ctctcagatc aagcaagaac cagaccccac   3240

gtggtagacc tcttccctcc taggcttaaa gtatcagtgg ttgagaagag cttttcggac   3300

ctgttactac cccaagctgt agccttgagt tacggtgttt attttccaat caagtgaaga   3360

tatctcctac ttctcctact ggaacatctc agcttctgca gtgaagaaaa attcctgtga   3420

tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat catttaaatg atcctttgtt   3480

cacggctctc cttaatgact gagtgaacag ttcctatctg tatatttgac taaacctttt   3540

cctaagctat ctctcatggt tcctatgttt ttttatcata attaaaagca aaaccatctg   3600

gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa ttatagagga aatacagaga   3660

gaacctcttc cacttttact tttcgtccaa ataaaatgca tggtgtacca gaagttgaag   3720

atcgggttga ggattggggc tagctcgatg acactaaggc cccaacatcg cgggacctgc   3780

tgtggcgcgg attcttagga acgctgttct agccggcccc ctctccaggg gtcgccgtgg   3840

ccggcattat ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg   3900

ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc ttcctaggag agtcttacat   3960

gtgttgagat ttcacaagca atgcgagttg taaaatacca gctctacaag aagctaggct   4020

ctgtgacggc atagttttca gtagctttat cacaatattc acaatggaga attatatgac   4080

atggtagcag aaataggccc ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat   4140

agggtaatca ataaaatcca tccatgcctt tcacacacta agt                     4183


<210>  4473
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  4473

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
465                 470                 475                 480


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
                485                 490                 495


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
            500                 505                 510


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
        515                 520                 525


Ser Ser Leu Leu Lys Asn Leu Asn 
    530                 535


<210>  4474
<211>  7817
<212>  DNA
<213>  Homo sapiens

<400>  4474
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gtcaaagaag attggaatgt cagaattacc aagctacgga   1920

agcaagtgga agagattttt aatttgaaat ttgctcaagc tcttggactc accgaggcag   1980

taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgtatgtg gaaggcttgc   2040

cagaggggat tcccttccga agccctacct ggtttggaat tccacgactt gaaaggatcg   2100

tccgcgggag taataaaatc aagttcgttg ttaaaaaacc tgaactagtt atttcctact   2160

tgcctcctgg gatggctagt aaaataaaca ctaaagcttt gcagtccccc aaaagaccac   2220

gaagtcctgg gagtaattca aaggttcctg aaattgaggt caccgtggaa ggccctaata   2280

acaacaatcc tcaaacctca gctgttcgaa ccccgaccca gactaacggt tctaacgttc   2340

ccttcaagcc acgagggaga gagttttcct ttgaggcctg gaatgccaaa atcacggacc   2400

taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg ggaagctctt ggccttaaac   2460

aagctgtgaa ggtgccgttc gcgttatttg agtctttccc ggaagacttt tatgtggaag   2520

gcttacctga gggtgtgcca ttccgaagac catcgacttt tggcattccg aggctggaga   2580

agatactcag aaacaaagcc aaaattaagt tcatcattaa aaagcccgaa atgtttgaga   2640

cggcgattaa ggagagcacc tcctctaaga gccctcccag aaaaataaat tcatcaccca   2700

atgttaatac tactgcatca ggtgttgaag accttaacat cattcaggtg acaattccag   2760

atgatgataa tgaaagactc tcgaaagttg aaaaagctag acagctaaga gaacaagtga   2820

atgacctctt tagtcggaaa tttggtgaag ctattggtat gggttttcct gtgaaagttc   2880

cctacaggaa aatcacaatt aaccctggct gtgtggtggt tgatggcatg cccccggggg   2940

tgtccttcaa agcccccagc tacctggaaa tcagctccat gagaaggatc ttagactctg   3000

ccgagtttat caaattcacg gtcattaggt aagtgagagt ttcctgctta gtcacaggag   3060

cgaatctgga gctcatgagg ctgactcttc taaaatgcag ccacaggtag tcatcgaatc   3120

cggcttccta tgctgtgcaa tcaacaaatc aaaataactt gtgtcatcat tagaatgtca   3180

gatgtgcttc tacgaactaa gctgactctt ttaattcttt ggcaaagggt tggcaaacta   3240

ggactgtttg ccaaattcag gctgcctcct atttttagag tcttcctgaa acacagctac   3300

acccgtatta tccatggctg ctttcctgtc acagtgagta agtagctggg actgagaagg   3360

catggcctcc aaagtctaaa atatttactc tctagcactt tgtagaaaaa ccttagctag   3420

gcacagtggc taacgcctgt aatcccagca ttttgggagg ccaaggcagg cagatcacct   3480

gaggtcagga gttccagacc agcctggcca acatggtgaa atcccatctc tacaaaaata   3540

aaacagttag ctgggcatga tggcgggtgc ctgtaatccc agctactcgg gaggctgagg   3600

caggatagtc gcttgaaccc aggaggtgga ggttgcaatg agccaagatc atgccactgc   3660

actccagcct ggacgacaga gtgagactcc atcacaagaa aaaaagaact ttgtcaacct   3720

ctgtcttagg gcgccttgtc acaggcttcg ggtcagacgg attcaacctt gcatcagcca   3780

tttgttagcc aggtcactct gttctttgtc tgtaaatgag attgatcgtt gttcccactg   3840

agagtgtcag ctccttcccg tagagcaggc atgatgattg tactcacctc tgacaccatt   3900

gtgagtgcca cattccttcc cacgtccttg tcactgtaag agatgcccac ctgagcacca   3960

accccaggtt atcttcccct ttgtcttcca gccccccaga aacagctacg actcaaccta   4020

cccaatcatt tcatcatcag attgccactg tctctagttc aggtctcttg ggactggcac   4080

tcagaaatct cataataaat cctcttgagg cttctcatac actcgtcttc ttccaatctt   4140

ctttccctca aaatctcata ttttggttcc acttcaccca ccgtcattct ccatatcact   4200

cccaggagtt aggcaaaaag ccccttccgt tcttccgtat gttaaactta gaatcactct   4260

gttccctgct ctgcgtttct attttttgtt tttcctccat ttactagtag cttaacactt   4320

tctaacagtg ttcttattat tgatacgtat ctatctcttc cataagctta taaggtcacg   4380

gataatactt ctcattgtag tacgtaaatg acgtgggcta gatatgagtt gaataaacag   4440

ttatacctgt aaattcttac agagtgaaaa taaattgtta tactttacaa tttgtttctc   4500

tctttagacc atttccagga cttgtgatta ataaccgtga gtattttgtg aagtgttttg   4560

tttttgtttt ttcctggggt ctgacgtgtg tgcgtgtgag tgtgtataca tgcttaacgt   4620

atatcacgtt acttcaccta tgtcagtaac caggccaaat acttgtttta gccctcagta   4680

aaaacaccag gcacttccta gttgtaaaat tattcaagct tcttaacttc ctatcctcga   4740

tgcacttaat cataaaatgg taataatagc accgattttg ggggagtcgt tccagtagat   4800

ggaaagcatc tggaacaggt gtcagcaagc tcctgccgac gtgtatgcat aaagttttat   4860

tgaaaccacc atcgtgtcca tttgtttatg gcagaactga gagatggcag cagcaagtgt   4920

gtgcctgcaa aacctaaaat atttactaat tggctctgca agaaaagagt ttgcatcccc   4980

ctaacctaga acagtgtcta gcctctagta tgtgtttagc ctacagtatg tgctcagcga   5040

atacaatcta tatttattac tgcttttatg actgttataa ttactgtgct tggatttcgt   5100

tacaaagtaa gtcacaatgt gcctgcttct gttagtattt cagcacagtg cctggcacac   5160

atggggctct caaatattgc tgagcgagtg aacaaatgtc ctttcaattc cttaacgttg   5220

atgtcatttt caatagtatt ttgagccaaa cttaattttg cgagtgtgtt ttgttttctt   5280

aactttatta ttaaaaatgt ataaaagtga ggccaggcgt ggtggctcac gcctgtaatc   5340

ccagcagttt gggaggctga ggcaggcgga tcagttgagg ttgggagttg gagaccagcc   5400

cgtccaacat ggtgaaagcc tgtctctact aaaaatacaa aaatcagctg ggtgtggtgg   5460

cgcgtgcctg taatcccagc tactcaggag gctgaggcag gagagttgct tgaatcctag   5520

aggtggaggt tgcagtgagc tgagatcgtg ccattgcact ccagcctggg caacaagagc   5580

aaaactctgt cccaataaat aaataaataa aatgttctct tttgttcctg ttcttgtgcg   5640

gtagtgtggt atagagtttt atggtaatta ctgtgaatta gtgattctga gggacatatc   5700

agaactctga ggtttgtttc cttctcatct tgagggaaac agcaaatgta tgttaaaatg   5760

cttttccaag ggaacaacac atccttacat tatttaaacc aatctgcttc attttcagag   5820

ctggttgatc agagtgagtc agaaggcccc gtgatacaag aatcagctga accaagccag   5880

ttggaagttc cagccacaga agaaataaaa gagactgatg gaagctctca gatcaagcaa   5940

gaaccagacc ccacgtggta gacctcttcc ctcctagggt aaatcagctt ctgtgtcagg   6000

gatgctgtgt ggtgtccatc tgaaccccct gcatacgcgt agctaatgtg atctccccac   6060

tttcacataa gatggtggcc ctgccttcag ggaatgtggg agccaggtgg gagccttccc   6120

ggatatttaa gctagaagat tctacaggga gattctcctt ggatcaatat atgtctctca   6180

gtcaaagatg taaaagcact tttgccttaa aaagaatgtt ctgtttctaa atagagtcaa   6240

cgttgtcctc ctcattggaa ttcactatga gtcagaatca ttagactgac tttttttttt   6300

ccatagtaat agtattttgc agagtctcac agagctgcag atcttttgtt catcttgcag   6360

agttaacaag tctgatcctg ttagtccaga tttcttaaat ttggccaagt tataatagga   6420

gcagtagctt gagacccgaa gtcaggaaac tttgacaatg gatttttttt tttaatccag   6480

agacttgtac tggaatttgc cttaccctgt cagctcatgg acttaaggtt tcatcccgct   6540

ttatgagtgc ttctgaatcc aagtcattgt tacctgaatt tgcaaattaa gttgtgatat   6600

tcgtgactgt taaattcctg taattagatt aacctctttg cttgcttgtt tgttttctct   6660

cctattttag cttaaagtat cagtggttga gaagagcttt tcggacctgt tactacccca   6720

agctgtgtaa tatacttgta taacagaaat accttctata caaacctttt tttctacttt   6780

tagatagaaa tgtctacttt ttcagcagtt ctgtgaatta aagagcagag tgactgtggg   6840

tctggaatgg ctggtgtact tgggaatgta ctatcaggat tttacagcaa tgctgggaaa   6900

tgacagggaa aatgacagga atgaatctca ccagattttt tatgtactca gcagagcctt   6960

gagttacggt gtttattttc caatcaagtg aagatatctc ctacttctcc tactggaaca   7020

tctcagcttc tgcagtgaag aaaaattcct gtgatagttc agttctttag tttttctatt   7080

tgaaaaaaaa aaatcattta aatgatcctt tgttcacggc tctccttaat gactgagtga   7140

acagttccta tctgtatatt tgactaaacc ttttcctaag ctatctctca tggttcctat   7200

gtttttttat cataattaaa agcaaaacca tctggatcac ctaacagtca gaggtcagta   7260

tctcagcgtg tgaattatag aggaaataca gagagaacct cttccacttt tacttttcgt   7320

ccaaataaaa tgcatggtgt accagaagtt gaagatcggg ttgaggattg gggctagctc   7380

gatgacacta aggccccaac atcgcgggac ctgctgtggc gcggattctt aggaacgctg   7440

ttctagccgg ccccctctcc aggggtcgcc gtggccggca ttatttccta gttcttcttg   7500

taaccctgag gtgccagcgc ggggagtgag gaggggtcag ggggctaagg atgcaacctc   7560

tgacgttctg cgccttccta ggagagtctt acatgtgttg agatttcaca agcaatgcga   7620

gttgtaaaat accagctcta caagaagcta ggctctgtga cggcatagtt ttcagtagct   7680

ttatcacaat attcacaatg gagaattata tgacatggta gcagaaatag gcccttttat   7740

gtgttgcttc tattttacct caaattgtag atatagggta atcaataaaa tccatccatg   7800

cctttcacac actaagt                                                  7817


<210>  4475
<211>  876
<212>  PRT
<213>  Homo sapiens

<400>  4475

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
                485                 490                 495


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
            500                 505                 510


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
        515                 520                 525


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu 
    530                 535                 540


Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile 
545                 550                 555                 560


Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val 
                565                 570                 575


Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala 
            580                 585                 590


Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser 
        595                 600                 605


Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly 
    610                 615                 620


Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln 
625                 630                 635                 640


Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser 
                645                 650                 655


Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu 
            660                 665                 670


Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala 
        675                 680                 685


Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr 
    690                 695                 700


Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe 
705                 710                 715                 720


Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys 
                725                 730                 735


Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser 
            740                 745                 750


Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val 
        755                 760                 765


Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr 
    770                 775                 780


Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg 
785                 790                 795                 800


Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu 
                805                 810                 815


Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr 
            820                 825                 830


Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser 
        835                 840                 845


Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu 
    850                 855                 860


Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
865                 870                 875


<210>  4476
<211>  5064
<212>  DNA
<213>  Homo sapiens

<400>  4476
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gctcaagctc ttggactcac   1980

cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct tgtatgtgga   2040

aggcttgcca gaggggattc ccttccgaag ccctacctgg tttggaattc cacgacttga   2100

aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg aactagttat   2160

ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc agtcccccaa   2220

aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg   2280

ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga ctaacggttc   2340

taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga atgccaaaat   2400

cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg   2460

ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg aagactttta   2520

tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg gcattccgag   2580

gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa agcccgaaat   2640

gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa aaataaattc   2700

atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca ttcaggtgac   2760

aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac agctaagaga   2820

acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg gttttcctgt   2880

gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg atggcatgcc   2940

cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga gaaggatctt   3000

agactctgcc gagtttatca aattcacggt cattagacca tttccaggac ttgtgattaa   3060

taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat cagctgaacc   3120

aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa gctctcagat   3180

caagcaagaa ccagacccca cgtggtagac ctcttccctc ctagggtaaa tcagcttctg   3240

tgtcagggat gctgtgtggt gtccatctga accccctgca tacgcgtagc taatgtgatc   3300

tccccacttt cacataagat ggtggccctg ccttcaggga atgtgggagc caggtgggag   3360

ccttcccgga tatttaagct agaagattct acagggagat tctccttgga tcaatatatg   3420

tctctcagtc aaagatgtaa aagcactttt gccttaaaaa gaatgttctg tttctaaata   3480

gagtcaacgt tgtcctcctc attggaattc actatgagtc agaatcatta gactgacttt   3540

tttttttcca tagtaatagt attttgcaga gtctcacaga gctgcagatc ttttgttcat   3600

cttgcagagt taacaagtct gatcctgtta gtccagattt cttaaatttg gccaagttat   3660

aataggagca gtagcttgag acccgaagtc aggaaacttt gacaatggat tttttttttt   3720

aatccagaga cttgtactgg aatttgcctt accctgtcag ctcatggact taaggtttca   3780

tcccgcttta tgagtgcttc tgaatccaag tcattgttac ctgaatttgc aaattaagtt   3840

gtgatattcg tgactgttaa attcctgtaa ttagattaac ctctttgctt gcttgtttgt   3900

tttctctcct attttagctt aaagtatcag tggttgagaa gagcttttcg gacctgttac   3960

taccccaagc tgtgtaatat acttgtataa cagaaatacc ttctatacaa accttttttt   4020

ctacttttag atagaaatgt ctactttttc agcagttctg tgaattaaag agcagagtga   4080

ctgtgggtct ggaatggctg gtgtacttgg gaatgtacta tcaggatttt acagcaatgc   4140

tgggaaatga cagggaaaat gacaggaatg aatctcacca gattttttat gtactcagca   4200

gagccttgag ttacggtgtt tattttccaa tcaagtgaag atatctccta cttctcctac   4260

tggaacatct cagcttctgc agtgaagaaa aattcctgtg atagttcagt tctttagttt   4320

ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt tcacggctct ccttaatgac   4380

tgagtgaaca gttcctatct gtatatttga ctaaaccttt tcctaagcta tctctcatgg   4440

ttcctatgtt tttttatcat aattaaaagc aaaaccatct ggatcaccta acagtcagag   4500

gtcagtatct cagcgtgtga attatagagg aaatacagag agaacctctt ccacttttac   4560

ttttcgtcca aataaaatgc atggtgtacc agaagttgaa gatcgggttg aggattgggg   4620

ctagctcgat gacactaagg ccccaacatc gcgggacctg ctgtggcgcg gattcttagg   4680

aacgctgttc tagccggccc cctctccagg ggtcgccgtg gccggcatta tttcctagtt   4740

cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg gctaaggatg   4800

caacctctga cgttctgcgc cttcctagga gagtcttaca tgtgttgaga tttcacaagc   4860

aatgcgagtt gtaaaatacc agctctacaa gaagctaggc tctgtgacgg catagttttc   4920

agtagcttta tcacaatatt cacaatggag aattatatga catggtagca gaaataggcc   4980

cttttatgtg ttgcttctat tttacctcaa attgtagata tagggtaatc aataaaatcc   5040

atccatgcct ttcacacact aagt                                          5064


<210>  4477
<211>  928
<212>  PRT
<213>  Homo sapiens

<400>  4477

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro 
        515                 520                 525


Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu 
    530                 535                 540


Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu 
545                 550                 555                 560


Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro 
                565                 570                 575


Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn 
            580                 585                 590


Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn 
        595                 600                 605


Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn 
    610                 615                 620


Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser 
625                 630                 635                 640


Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp 
                645                 650                 655


Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn 
            660                 665                 670


Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro 
        675                 680                 685


Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu 
    690                 695                 700


Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg 
705                 710                 715                 720


Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys 
                725                 730                 735


Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys 
            740                 745                 750


Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala 
        755                 760                 765


Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp 
    770                 775                 780


Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu 
785                 790                 795                 800


Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met 
                805                 810                 815


Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly 
            820                 825                 830


Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro 
        835                 840                 845


Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu 
    850                 855                 860


Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn 
865                 870                 875                 880


Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu 
                885                 890                 895


Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys 
            900                 905                 910


Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
        915                 920                 925


<210>  4478
<211>  4008
<212>  DNA
<213>  Homo sapiens

<400>  4478
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gctcaagctc ttggactcac cgaggcagta aaagtaccat   1920

atcctgtgtt tgaatcaaac ccggagttct tgtatgtgga aggcttgcca gaggggattc   1980

ccttccgaag ccctacctgg tttggaattc cacgacttga aaggatcgtc cgcgggagta   2040

ataaaatcaa gttcgttgtt aaaaaacctg aactagttat ttcctacttg cctcctggga   2100

tggctagtaa aataaacact aaagctttgc agtcccccaa aagaccacga agtcctggga   2160

gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg ccctaataac aacaatcctc   2220

aaacctcagc tgttcgaacc ccgacccaga ctaacggttc taacgttccc ttcaagccac   2280

gagggagaga gttttccttt gaggcctgga atgccaaaat cacggaccta aaacagaaag   2340

ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg   2400

tgccgttcgc gttatttgag tctttcccgg aagactttta tgtggaaggc ttacctgagg   2460

gtgtgccatt ccgaagacca tcgacttttg gcattccgag gctggagaag atactcagaa   2520

acaaagccaa aattaagttc atcattaaaa agcccgaaat gtttgagacg gcgattaagg   2580

agagcacctc ctctaagagc cctcccagaa aaataaattc atcacccaat gttaatacta   2640

ctgcatcagg tgttgaagac cttaacatca ttcaggtgac aattccagat gatgataatg   2700

aaagactctc gaaagttgaa aaagctagac agctaagaga acaagtgaat gacctcttta   2760

gtcggaaatt tggtgaagct attggtatgg gttttcctgt gaaagttccc tacaggaaaa   2820

tcacaattaa ccctggctgt gtggtggttg atggcatgcc cccgggggtg tccttcaaag   2880

cccccagcta cctggaaatc agctccatga gaaggatctt agactctgcc gagtttatca   2940

aattcacggt cattagacca tttccaggac ttgtgattaa taaccagctg gttgatcaga   3000

gtgagtcaga aggccccgtg atacaagaat cagctgaacc aagccagttg gaagttccag   3060

ccacagaaga aataaaagag actgatggaa gctctcagat caagcaagaa ccagacccca   3120

cgtggtagac ctcttccctc ctaggagcct tgagttacgg tgtttatttt ccaatcaagt   3180

gaagatatct cctacttctc ctactggaac atctcagctt ctgcagtgaa gaaaaattcc   3240

tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct   3300

ttgttcacgg ctctccttaa tgactgagtg aacagttcct atctgtatat ttgactaaac   3360

cttttcctaa gctatctctc atggttccta tgttttttta tcataattaa aagcaaaacc   3420

atctggatca cctaacagtc agaggtcagt atctcagcgt gtgaattata gaggaaatac   3480

agagagaacc tcttccactt ttacttttcg tccaaataaa atgcatggtg taccagaagt   3540

tgaagatcgg gttgaggatt ggggctagct cgatgacact aaggccccaa catcgcggga   3600

cctgctgtgg cgcggattct taggaacgct gttctagccg gccccctctc caggggtcgc   3660

cgtggccggc attatttcct agttcttctt gtaaccctga ggtgccagcg cggggagtga   3720

ggaggggtca gggggctaag gatgcaacct ctgacgttct gcgccttcct aggagagtct   3780

tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa taccagctct acaagaagct   3840

aggctctgtg acggcatagt tttcagtagc tttatcacaa tattcacaat ggagaattat   3900

atgacatggt agcagaaata ggccctttta tgtgttgctt ctattttacc tcaaattgta   3960

gatatagggt aatcaataaa atccatccat gcctttcaca cactaagt                4008


<210>  4479
<211>  908
<212>  PRT
<213>  Homo sapiens

<400>  4479

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala 
                485                 490                 495


Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser 
            500                 505                 510


Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        515                 520                 525


Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg 
    530                 535                 540


Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile 
545                 550                 555                 560


Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu 
                565                 570                 575


Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro 
            580                 585                 590


Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr 
        595                 600                 605


Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe 
    610                 615                 620


Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile 
625                 630                 635                 640


Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly 
                645                 650                 655


Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe 
            660                 665                 670


Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val 
        675                 680                 685


Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile 
    690                 695                 700


Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met 
705                 710                 715                 720


Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg 
                725                 730                 735


Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu 
            740                 745                 750


Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg 
        755                 760                 765


Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp 
    770                 775                 780


Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val 
785                 790                 795                 800


Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val 
                805                 810                 815


Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu 
            820                 825                 830


Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe 
        835                 840                 845


Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val 
    850                 855                 860


Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro 
865                 870                 875                 880


Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly 
                885                 890                 895


Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
            900                 905


<210>  4480
<211>  4975
<212>  DNA
<213>  Homo sapiens

<400>  4480
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agctcaagct cttggactca ccgaggcagt aaaagtacca tatcctgtgt   1920

ttgaatcaaa cccggagttc ttgtatgtgg aaggcttgcc agaggggatt cccttccgaa   1980

gccctacctg gtttggaatt ccacgacttg aaaggatcgt ccgcgggagt aataaaatca   2040

agttcgttgt taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta   2100

aaataaacac taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa   2160

aggttcctga aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag   2220

ctgttcgaac cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag   2280

agttttcctt tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc   2340

tcttcaatga gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg   2400

cgttatttga gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat   2460

tccgaagacc atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca   2520

aaattaagtt catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct   2580

cctctaagag ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag   2640

gtgttgaaga ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct   2700

cgaaagttga aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat   2760

ttggtgaagc tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta   2820

accctggctg tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct   2880

acctggaaat cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg   2940

tcattagacc atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag   3000

aaggccccgt gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag   3060

aaataaaaga gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga   3120

cctcttccct cctagggtaa atcagcttct gtgtcaggga tgctgtgtgg tgtccatctg   3180

aaccccctgc atacgcgtag ctaatgtgat ctccccactt tcacataaga tggtggccct   3240

gccttcaggg aatgtgggag ccaggtggga gccttcccgg atatttaagc tagaagattc   3300

tacagggaga ttctccttgg atcaatatat gtctctcagt caaagatgta aaagcacttt   3360

tgccttaaaa agaatgttct gtttctaaat agagtcaacg ttgtcctcct cattggaatt   3420

cactatgagt cagaatcatt agactgactt ttttttttcc atagtaatag tattttgcag   3480

agtctcacag agctgcagat cttttgttca tcttgcagag ttaacaagtc tgatcctgtt   3540

agtccagatt tcttaaattt ggccaagtta taataggagc agtagcttga gacccgaagt   3600

caggaaactt tgacaatgga tttttttttt taatccagag acttgtactg gaatttgcct   3660

taccctgtca gctcatggac ttaaggtttc atcccgcttt atgagtgctt ctgaatccaa   3720

gtcattgtta cctgaatttg caaattaagt tgtgatattc gtgactgtta aattcctgta   3780

attagattaa cctctttgct tgcttgtttg ttttctctcc tattttagct taaagtatca   3840

gtggttgaga agagcttttc ggacctgtta ctaccccaag ctgtgtaata tacttgtata   3900

acagaaatac cttctataca aacctttttt tctactttta gatagaaatg tctacttttt   3960

cagcagttct gtgaattaaa gagcagagtg actgtgggtc tggaatggct ggtgtacttg   4020

ggaatgtact atcaggattt tacagcaatg ctgggaaatg acagggaaaa tgacaggaat   4080

gaatctcacc agatttttta tgtactcagc agagccttga gttacggtgt ttattttcca   4140

atcaagtgaa gatatctcct acttctccta ctggaacatc tcagcttctg cagtgaagaa   4200

aaattcctgt gatagttcag ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa   4260

tgatcctttg ttcacggctc tccttaatga ctgagtgaac agttcctatc tgtatatttg   4320

actaaacctt ttcctaagct atctctcatg gttcctatgt ttttttatca taattaaaag   4380

caaaaccatc tggatcacct aacagtcaga ggtcagtatc tcagcgtgtg aattatagag   4440

gaaatacaga gagaacctct tccactttta cttttcgtcc aaataaaatg catggtgtac   4500

cagaagttga agatcgggtt gaggattggg gctagctcga tgacactaag gccccaacat   4560

cgcgggacct gctgtggcgc ggattcttag gaacgctgtt ctagccggcc ccctctccag   4620

gggtcgccgt ggccggcatt atttcctagt tcttcttgta accctgaggt gccagcgcgg   4680

ggagtgagga ggggtcaggg ggctaaggat gcaacctctg acgttctgcg ccttcctagg   4740

agagtcttac atgtgttgag atttcacaag caatgcgagt tgtaaaatac cagctctaca   4800

agaagctagg ctctgtgacg gcatagtttt cagtagcttt atcacaatat tcacaatgga   4860

gaattatatg acatggtagc agaaataggc ccttttatgt gttgcttcta ttttacctca   4920

aattgtagat atagggtaat caataaaatc catccatgcc tttcacacac taagt        4975


<210>  4481
<211>  844
<212>  PRT
<213>  Homo sapiens

<400>  4481

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala 
            420                 425                 430


Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser 
        435                 440                 445


Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
    450                 455                 460


Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg 
465                 470                 475                 480


Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile 
                485                 490                 495


Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu 
            500                 505                 510


Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro 
        515                 520                 525


Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr 
    530                 535                 540


Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe 
545                 550                 555                 560


Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile 
                565                 570                 575


Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly 
            580                 585                 590


Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe 
        595                 600                 605


Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val 
    610                 615                 620


Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile 
625                 630                 635                 640


Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met 
                645                 650                 655


Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg 
            660                 665                 670


Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu 
        675                 680                 685


Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg 
    690                 695                 700


Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp 
705                 710                 715                 720


Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val 
                725                 730                 735


Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val 
            740                 745                 750


Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu 
        755                 760                 765


Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe 
    770                 775                 780


Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val 
785                 790                 795                 800


Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro 
                805                 810                 815


Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly 
            820                 825                 830


Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
        835                 840


<210>  4482
<211>  7892
<212>  DNA
<213>  Homo sapiens

<400>  4482
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1980

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   2040

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttgt   2100

atgtggaagg cttgccagag gggattccct tccgaagccc tacctggttt ggaattccac   2160

gacttgaaag gatcgtccgc gggagtaata aaatcaagtt cgttgttaaa aaacctgaac   2220

tagttatttc ctacttgcct cctgggatgg ctagtaaaat aaacactaaa gctttgcagt   2280

cccccaaaag accacgaagt cctgggagta attcaaaggt tcctgaaatt gaggtcaccg   2340

tggaaggccc taataacaac aatcctcaaa cctcagctgt tcgaaccccg acccagacta   2400

acggttctaa cgttcccttc aagccacgag ggagagagtt ttcctttgag gcctggaatg   2460

ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt caatgagaaa tgtggggaag   2520

ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt atttgagtct ttcccggaag   2580

acttttatgt ggaaggctta cctgagggtg tgccattccg aagaccatcg acttttggca   2640

ttccgaggct ggagaagata ctcagaaaca aagccaaaat taagttcatc attaaaaagc   2700

ccgaaatgtt tgagacggcg attaaggaga gcacctcctc taagagccct cccagaaaaa   2760

taaattcatc acccaatgtt aatactactg catcaggtgt tgaagacctt aacatcattc   2820

aggtgacaat tccagatgat gataatgaaa gactctcgaa agttgaaaaa gctagacagc   2880

taagagaaca agtgaatgac ctctttagtc ggaaatttgg tgaagctatt ggtatgggtt   2940

ttcctgtgaa agttccctac aggaaaatca caattaaccc tggctgtgtg gtggttgatg   3000

gcatgccccc gggggtgtcc ttcaaagccc ccagctacct ggaaatcagc tccatgagaa   3060

ggatcttaga ctctgccgag tttatcaaat tcacggtcat taggtaagtg agagtttcct   3120

gcttagtcac aggagcgaat ctggagctca tgaggctgac tcttctaaaa tgcagccaca   3180

ggtagtcatc gaatccggct tcctatgctg tgcaatcaac aaatcaaaat aacttgtgtc   3240

atcattagaa tgtcagatgt gcttctacga actaagctga ctcttttaat tctttggcaa   3300

agggttggca aactaggact gtttgccaaa ttcaggctgc ctcctatttt tagagtcttc   3360

ctgaaacaca gctacacccg tattatccat ggctgctttc ctgtcacagt gagtaagtag   3420

ctgggactga gaaggcatgg cctccaaagt ctaaaatatt tactctctag cactttgtag   3480

aaaaacctta gctaggcaca gtggctaacg cctgtaatcc cagcattttg ggaggccaag   3540

gcaggcagat cacctgaggt caggagttcc agaccagcct ggccaacatg gtgaaatccc   3600

atctctacaa aaataaaaca gttagctggg catgatggcg ggtgcctgta atcccagcta   3660

ctcgggaggc tgaggcagga tagtcgcttg aacccaggag gtggaggttg caatgagcca   3720

agatcatgcc actgcactcc agcctggacg acagagtgag actccatcac aagaaaaaaa   3780

gaactttgtc aacctctgtc ttagggcgcc ttgtcacagg cttcgggtca gacggattca   3840

accttgcatc agccatttgt tagccaggtc actctgttct ttgtctgtaa atgagattga   3900

tcgttgttcc cactgagagt gtcagctcct tcccgtagag caggcatgat gattgtactc   3960

acctctgaca ccattgtgag tgccacattc cttcccacgt ccttgtcact gtaagagatg   4020

cccacctgag caccaacccc aggttatctt cccctttgtc ttccagcccc ccagaaacag   4080

ctacgactca acctacccaa tcatttcatc atcagattgc cactgtctct agttcaggtc   4140

tcttgggact ggcactcaga aatctcataa taaatcctct tgaggcttct catacactcg   4200

tcttcttcca atcttctttc cctcaaaatc tcatattttg gttccacttc acccaccgtc   4260

attctccata tcactcccag gagttaggca aaaagcccct tccgttcttc cgtatgttaa   4320

acttagaatc actctgttcc ctgctctgcg tttctatttt ttgtttttcc tccatttact   4380

agtagcttaa cactttctaa cagtgttctt attattgata cgtatctatc tcttccataa   4440

gcttataagg tcacggataa tacttctcat tgtagtacgt aaatgacgtg ggctagatat   4500

gagttgaata aacagttata cctgtaaatt cttacagagt gaaaataaat tgttatactt   4560

tacaatttgt ttctctcttt agaccatttc caggacttgt gattaataac cgtgagtatt   4620

ttgtgaagtg ttttgttttt gttttttcct ggggtctgac gtgtgtgcgt gtgagtgtgt   4680

atacatgctt aacgtatatc acgttacttc acctatgtca gtaaccaggc caaatacttg   4740

ttttagccct cagtaaaaac accaggcact tcctagttgt aaaattattc aagcttctta   4800

acttcctatc ctcgatgcac ttaatcataa aatggtaata atagcaccga ttttggggga   4860

gtcgttccag tagatggaaa gcatctggaa caggtgtcag caagctcctg ccgacgtgta   4920

tgcataaagt tttattgaaa ccaccatcgt gtccatttgt ttatggcaga actgagagat   4980

ggcagcagca agtgtgtgcc tgcaaaacct aaaatattta ctaattggct ctgcaagaaa   5040

agagtttgca tccccctaac ctagaacagt gtctagcctc tagtatgtgt ttagcctaca   5100

gtatgtgctc agcgaataca atctatattt attactgctt ttatgactgt tataattact   5160

gtgcttggat ttcgttacaa agtaagtcac aatgtgcctg cttctgttag tatttcagca   5220

cagtgcctgg cacacatggg gctctcaaat attgctgagc gagtgaacaa atgtcctttc   5280

aattccttaa cgttgatgtc attttcaata gtattttgag ccaaacttaa ttttgcgagt   5340

gtgttttgtt ttcttaactt tattattaaa aatgtataaa agtgaggcca ggcgtggtgg   5400

ctcacgcctg taatcccagc agtttgggag gctgaggcag gcggatcagt tgaggttggg   5460

agttggagac cagcccgtcc aacatggtga aagcctgtct ctactaaaaa tacaaaaatc   5520

agctgggtgt ggtggcgcgt gcctgtaatc ccagctactc aggaggctga ggcaggagag   5580

ttgcttgaat cctagaggtg gaggttgcag tgagctgaga tcgtgccatt gcactccagc   5640

ctgggcaaca agagcaaaac tctgtcccaa taaataaata aataaaatgt tctcttttgt   5700

tcctgttctt gtgcggtagt gtggtataga gttttatggt aattactgtg aattagtgat   5760

tctgagggac atatcagaac tctgaggttt gtttccttct catcttgagg gaaacagcaa   5820

atgtatgtta aaatgctttt ccaagggaac aacacatcct tacattattt aaaccaatct   5880

gcttcatttt cagagctggt tgatcagagt gagtcagaag gccccgtgat acaagaatca   5940

gctgaaccaa gccagttgga agttccagcc acagaagaaa taaaagagac tgatggaagc   6000

tctcagatca agcaagaacc agaccccacg tggtagacct cttccctcct agggtaaatc   6060

agcttctgtg tcagggatgc tgtgtggtgt ccatctgaac cccctgcata cgcgtagcta   6120

atgtgatctc cccactttca cataagatgg tggccctgcc ttcagggaat gtgggagcca   6180

ggtgggagcc ttcccggata tttaagctag aagattctac agggagattc tccttggatc   6240

aatatatgtc tctcagtcaa agatgtaaaa gcacttttgc cttaaaaaga atgttctgtt   6300

tctaaataga gtcaacgttg tcctcctcat tggaattcac tatgagtcag aatcattaga   6360

ctgacttttt tttttccata gtaatagtat tttgcagagt ctcacagagc tgcagatctt   6420

ttgttcatct tgcagagtta acaagtctga tcctgttagt ccagatttct taaatttggc   6480

caagttataa taggagcagt agcttgagac ccgaagtcag gaaactttga caatggattt   6540

ttttttttaa tccagagact tgtactggaa tttgccttac cctgtcagct catggactta   6600

aggtttcatc ccgctttatg agtgcttctg aatccaagtc attgttacct gaatttgcaa   6660

attaagttgt gatattcgtg actgttaaat tcctgtaatt agattaacct ctttgcttgc   6720

ttgtttgttt tctctcctat tttagcttaa agtatcagtg gttgagaaga gcttttcgga   6780

cctgttacta ccccaagctg tgtaatatac ttgtataaca gaaatacctt ctatacaaac   6840

ctttttttct acttttagat agaaatgtct actttttcag cagttctgtg aattaaagag   6900

cagagtgact gtgggtctgg aatggctggt gtacttggga atgtactatc aggattttac   6960

agcaatgctg ggaaatgaca gggaaaatga caggaatgaa tctcaccaga ttttttatgt   7020

actcagcaga gccttgagtt acggtgttta ttttccaatc aagtgaagat atctcctact   7080

tctcctactg gaacatctca gcttctgcag tgaagaaaaa ttcctgtgat agttcagttc   7140

tttagttttt ctatttgaaa aaaaaaaatc atttaaatga tcctttgttc acggctctcc   7200

ttaatgactg agtgaacagt tcctatctgt atatttgact aaaccttttc ctaagctatc   7260

tctcatggtt cctatgtttt tttatcataa ttaaaagcaa aaccatctgg atcacctaac   7320

agtcagaggt cagtatctca gcgtgtgaat tatagaggaa atacagagag aacctcttcc   7380

acttttactt ttcgtccaaa taaaatgcat ggtgtaccag aagttgaaga tcgggttgag   7440

gattggggct agctcgatga cactaaggcc ccaacatcgc gggacctgct gtggcgcgga   7500

ttcttaggaa cgctgttcta gccggccccc tctccagggg tcgccgtggc cggcattatt   7560

tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc   7620

taaggatgca acctctgacg ttctgcgcct tcctaggaga gtcttacatg tgttgagatt   7680

tcacaagcaa tgcgagttgt aaaataccag ctctacaaga agctaggctc tgtgacggca   7740

tagttttcag tagctttatc acaatattca caatggagaa ttatatgaca tggtagcaga   7800

aataggccct tttatgtgtt gcttctattt tacctcaaat tgtagatata gggtaatcaa   7860

taaaatccat ccatgccttt cacacactaa gt                                 7892


<210>  4483
<211>  901
<212>  PRT
<213>  Homo sapiens

<400>  4483

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
                565                 570                 575


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
            580                 585                 590


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
        595                 600                 605


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
    610                 615                 620


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
625                 630                 635                 640


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
                645                 650                 655


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
            660                 665                 670


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
        675                 680                 685


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
    690                 695                 700


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
705                 710                 715                 720


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
                725                 730                 735


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
            740                 745                 750


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
        755                 760                 765


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
    770                 775                 780


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
785                 790                 795                 800


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
                805                 810                 815


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
            820                 825                 830


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
        835                 840                 845


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
    850                 855                 860


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
865                 870                 875                 880


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
                885                 890                 895


Phe Thr Val Ile Arg 
            900


<210>  4484
<211>  4067
<212>  DNA
<213>  Homo sapiens

<400>  4484
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040

taccatatcc tgtgtttgaa tcaaacccgg agttcttgaa aggatcgtcc gcgggagtaa   2100

taaaatcaag ttcgttgtta aaaaacctga actagttatt tcctacttgc ctcctgggat   2160

ggctagtaaa ataaacacta aagctttgca gtcccccaaa agaccacgaa gtcctgggag   2220

taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc cctaataaca acaatcctca   2280

aacctcagct gttcgaaccc cgacccagac taacggttct aacgttccct tcaagccacg   2340

agggagagag ttttcctttg aggcctggaa tgccaaaatc acggacctaa aacagaaagt   2400

tgaaaatctc ttcaatgaga aatgtgggga agctcttggc cttaaacaag ctgtgaaggt   2460

gccgttcgcg ttatttgagt ctttcccgga agacttttat gtggaaggct tacctgaggg   2520

tgtgccattc cgaagaccat cgacttttgg cattccgagg ctggagaaga tactcagaaa   2580

caaagccaaa attaagttca tcattaaaaa gcccgaaatg tttgagacgg cgattaagga   2640

gagcacctcc tctaagagcc ctcccagaaa aataaattca tcacccaatg ttaatactac   2700

tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca attccagatg atgataatga   2760

aagactctcg aaagttgaaa aagctagaca gctaagagaa caagtgaatg acctctttag   2820

tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg aaagttccct acaggaaaat   2880

cacaattaac cctggctgtg tggtggttga tggcatgccc ccgggggtgt ccttcaaagc   2940

ccccagctac ctggaaatca gctccatgag aaggatctta gactctgccg agtttatcaa   3000

attcacggtc attagaccat ttccaggact tgtgattaat aaccagctgg ttgatcagag   3060

tgagtcagaa ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc   3120

cacagaagaa ataaaagaga ctgatggaag ctctcagatc aagcaagaac cagaccccac   3180

gtggtagacc tcttccctcc taggagcctt gagttacggt gtttattttc caatcaagtg   3240

aagatatctc ctacttctcc tactggaaca tctcagcttc tgcagtgaag aaaaattcct   3300

gtgatagttc agttctttag tttttctatt tgaaaaaaaa aaatcattta aatgatcctt   3360

tgttcacggc tctccttaat gactgagtga acagttccta tctgtatatt tgactaaacc   3420

ttttcctaag ctatctctca tggttcctat gtttttttat cataattaaa agcaaaacca   3480

tctggatcac ctaacagtca gaggtcagta tctcagcgtg tgaattatag aggaaataca   3540

gagagaacct cttccacttt tacttttcgt ccaaataaaa tgcatggtgt accagaagtt   3600

gaagatcggg ttgaggattg gggctagctc gatgacacta aggccccaac atcgcgggac   3660

ctgctgtggc gcggattctt aggaacgctg ttctagccgg ccccctctcc aggggtcgcc   3720

gtggccggca ttatttccta gttcttcttg taaccctgag gtgccagcgc ggggagtgag   3780

gaggggtcag ggggctaagg atgcaacctc tgacgttctg cgccttccta ggagagtctt   3840

acatgtgttg agatttcaca agcaatgcga gttgtaaaat accagctcta caagaagcta   3900

ggctctgtga cggcatagtt ttcagtagct ttatcacaat attcacaatg gagaattata   3960

tgacatggta gcagaaatag gcccttttat gtgttgcttc tattttacct caaattgtag   4020

atatagggta atcaataaaa tccatccatg cctttcacac actaagt                 4067


<210>  4485
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  4485

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
    450                 455                 460


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
465                 470                 475                 480


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
                485                 490                 495


Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu 
            500                 505                 510


Lys Asn Leu Asn 
        515


<210>  4486
<211>  7888
<212>  DNA
<213>  Homo sapiens

<400>  4486
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   2040

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2100

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2160

tgaaaggatc gtccgcggga gtaataaaat caagttcgtt gttaaaaaac ctgaactagt   2220

tatttcctac ttgcctcctg ggatggctag taaaataaac actaaagctt tgcagtcccc   2280

caaaagacca cgaagtcctg ggagtaattc aaaggttcct gaaattgagg tcaccgtgga   2340

aggccctaat aacaacaatc ctcaaacctc agctgttcga accccgaccc agactaacgg   2400

ttctaacgtt cccttcaagc cacgagggag agagttttcc tttgaggcct ggaatgccaa   2460

aatcacggac ctaaaacaga aagttgaaaa tctcttcaat gagaaatgtg gggaagctct   2520

tggccttaaa caagctgtga aggtgccgtt cgcgttattt gagtctttcc cggaagactt   2580

ttatgtggaa ggcttacctg agggtgtgcc attccgaaga ccatcgactt ttggcattcc   2640

gaggctggag aagatactca gaaacaaagc caaaattaag ttcatcatta aaaagcccga   2700

aatgtttgag acggcgatta aggagagcac ctcctctaag agccctccca gaaaaataaa   2760

ttcatcaccc aatgttaata ctactgcatc aggtgttgaa gaccttaaca tcattcaggt   2820

gacaattcca gatgatgata atgaaagact ctcgaaagtt gaaaaagcta gacagctaag   2880

agaacaagtg aatgacctct ttagtcggaa atttggtgaa gctattggta tgggttttcc   2940

tgtgaaagtt ccctacagga aaatcacaat taaccctggc tgtgtggtgg ttgatggcat   3000

gcccccgggg gtgtccttca aagcccccag ctacctggaa atcagctcca tgagaaggat   3060

cttagactct gccgagttta tcaaattcac ggtcattagg taagtgagag tttcctgctt   3120

agtcacagga gcgaatctgg agctcatgag gctgactctt ctaaaatgca gccacaggta   3180

gtcatcgaat ccggcttcct atgctgtgca atcaacaaat caaaataact tgtgtcatca   3240

ttagaatgtc agatgtgctt ctacgaacta agctgactct tttaattctt tggcaaaggg   3300

ttggcaaact aggactgttt gccaaattca ggctgcctcc tatttttaga gtcttcctga   3360

aacacagcta cacccgtatt atccatggct gctttcctgt cacagtgagt aagtagctgg   3420

gactgagaag gcatggcctc caaagtctaa aatatttact ctctagcact ttgtagaaaa   3480

accttagcta ggcacagtgg ctaacgcctg taatcccagc attttgggag gccaaggcag   3540

gcagatcacc tgaggtcagg agttccagac cagcctggcc aacatggtga aatcccatct   3600

ctacaaaaat aaaacagtta gctgggcatg atggcgggtg cctgtaatcc cagctactcg   3660

ggaggctgag gcaggatagt cgcttgaacc caggaggtgg aggttgcaat gagccaagat   3720

catgccactg cactccagcc tggacgacag agtgagactc catcacaaga aaaaaagaac   3780

tttgtcaacc tctgtcttag ggcgccttgt cacaggcttc gggtcagacg gattcaacct   3840

tgcatcagcc atttgttagc caggtcactc tgttctttgt ctgtaaatga gattgatcgt   3900

tgttcccact gagagtgtca gctccttccc gtagagcagg catgatgatt gtactcacct   3960

ctgacaccat tgtgagtgcc acattccttc ccacgtcctt gtcactgtaa gagatgccca   4020

cctgagcacc aaccccaggt tatcttcccc tttgtcttcc agccccccag aaacagctac   4080

gactcaacct acccaatcat ttcatcatca gattgccact gtctctagtt caggtctctt   4140

gggactggca ctcagaaatc tcataataaa tcctcttgag gcttctcata cactcgtctt   4200

cttccaatct tctttccctc aaaatctcat attttggttc cacttcaccc accgtcattc   4260

tccatatcac tcccaggagt taggcaaaaa gccccttccg ttcttccgta tgttaaactt   4320

agaatcactc tgttccctgc tctgcgtttc tattttttgt ttttcctcca tttactagta   4380

gcttaacact ttctaacagt gttcttatta ttgatacgta tctatctctt ccataagctt   4440

ataaggtcac ggataatact tctcattgta gtacgtaaat gacgtgggct agatatgagt   4500

tgaataaaca gttatacctg taaattctta cagagtgaaa ataaattgtt atactttaca   4560

atttgtttct ctctttagac catttccagg acttgtgatt aataaccgtg agtattttgt   4620

gaagtgtttt gtttttgttt tttcctgggg tctgacgtgt gtgcgtgtga gtgtgtatac   4680

atgcttaacg tatatcacgt tacttcacct atgtcagtaa ccaggccaaa tacttgtttt   4740

agccctcagt aaaaacacca ggcacttcct agttgtaaaa ttattcaagc ttcttaactt   4800

cctatcctcg atgcacttaa tcataaaatg gtaataatag caccgatttt gggggagtcg   4860

ttccagtaga tggaaagcat ctggaacagg tgtcagcaag ctcctgccga cgtgtatgca   4920

taaagtttta ttgaaaccac catcgtgtcc atttgtttat ggcagaactg agagatggca   4980

gcagcaagtg tgtgcctgca aaacctaaaa tatttactaa ttggctctgc aagaaaagag   5040

tttgcatccc cctaacctag aacagtgtct agcctctagt atgtgtttag cctacagtat   5100

gtgctcagcg aatacaatct atatttatta ctgcttttat gactgttata attactgtgc   5160

ttggatttcg ttacaaagta agtcacaatg tgcctgcttc tgttagtatt tcagcacagt   5220

gcctggcaca catggggctc tcaaatattg ctgagcgagt gaacaaatgt cctttcaatt   5280

ccttaacgtt gatgtcattt tcaatagtat tttgagccaa acttaatttt gcgagtgtgt   5340

tttgttttct taactttatt attaaaaatg tataaaagtg aggccaggcg tggtggctca   5400

cgcctgtaat cccagcagtt tgggaggctg aggcaggcgg atcagttgag gttgggagtt   5460

ggagaccagc ccgtccaaca tggtgaaagc ctgtctctac taaaaataca aaaatcagct   5520

gggtgtggtg gcgcgtgcct gtaatcccag ctactcagga ggctgaggca ggagagttgc   5580

ttgaatccta gaggtggagg ttgcagtgag ctgagatcgt gccattgcac tccagcctgg   5640

gcaacaagag caaaactctg tcccaataaa taaataaata aaatgttctc ttttgttcct   5700

gttcttgtgc ggtagtgtgg tatagagttt tatggtaatt actgtgaatt agtgattctg   5760

agggacatat cagaactctg aggtttgttt ccttctcatc ttgagggaaa cagcaaatgt   5820

atgttaaaat gcttttccaa gggaacaaca catccttaca ttatttaaac caatctgctt   5880

cattttcaga gctggttgat cagagtgagt cagaaggccc cgtgatacaa gaatcagctg   5940

aaccaagcca gttggaagtt ccagccacag aagaaataaa agagactgat ggaagctctc   6000

agatcaagca agaaccagac cccacgtggt agacctcttc cctcctaggg taaatcagct   6060

tctgtgtcag ggatgctgtg tggtgtccat ctgaaccccc tgcatacgcg tagctaatgt   6120

gatctcccca ctttcacata agatggtggc cctgccttca gggaatgtgg gagccaggtg   6180

ggagccttcc cggatattta agctagaaga ttctacaggg agattctcct tggatcaata   6240

tatgtctctc agtcaaagat gtaaaagcac ttttgcctta aaaagaatgt tctgtttcta   6300

aatagagtca acgttgtcct cctcattgga attcactatg agtcagaatc attagactga   6360

cttttttttt tccatagtaa tagtattttg cagagtctca cagagctgca gatcttttgt   6420

tcatcttgca gagttaacaa gtctgatcct gttagtccag atttcttaaa tttggccaag   6480

ttataatagg agcagtagct tgagacccga agtcaggaaa ctttgacaat ggattttttt   6540

ttttaatcca gagacttgta ctggaatttg ccttaccctg tcagctcatg gacttaaggt   6600

ttcatcccgc tttatgagtg cttctgaatc caagtcattg ttacctgaat ttgcaaatta   6660

agttgtgata ttcgtgactg ttaaattcct gtaattagat taacctcttt gcttgcttgt   6720

ttgttttctc tcctatttta gcttaaagta tcagtggttg agaagagctt ttcggacctg   6780

ttactacccc aagctgtgta atatacttgt ataacagaaa taccttctat acaaaccttt   6840

ttttctactt ttagatagaa atgtctactt tttcagcagt tctgtgaatt aaagagcaga   6900

gtgactgtgg gtctggaatg gctggtgtac ttgggaatgt actatcagga ttttacagca   6960

atgctgggaa atgacaggga aaatgacagg aatgaatctc accagatttt ttatgtactc   7020

agcagagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct cctacttctc   7080

ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta   7140

gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg ctctccttaa   7200

tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa gctatctctc   7260

atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca cctaacagtc   7320

agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc tcttccactt   7380

ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg gttgaggatt   7440

ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg cgcggattct   7500

taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc attatttcct   7560

agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca gggggctaag   7620

gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt gagatttcac   7680

aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg acggcatagt   7740

tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt agcagaaata   7800

ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt aatcaataaa   7860

atccatccat gcctttcaca cactaagt                                      7888


<210>  4487
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  4487

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala 
            580                 585                 590


Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600                 605


<210>  4488
<211>  7931
<212>  DNA
<213>  Homo sapiens

<400>  4488
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   2040

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2100

taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2160

ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2220

ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2280

ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2340

ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2400

atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2460

agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2520

agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2580

tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2640

ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2700

tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2760

ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2820

atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2880

ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2940

tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   3000

ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   3060

tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3120

ttatcaaatt cacggtcatt aggtaagtga gagtttcctg cttagtcaca ggagcgaatc   3180

tggagctcat gaggctgact cttctaaaat gcagccacag gtagtcatcg aatccggctt   3240

cctatgctgt gcaatcaaca aatcaaaata acttgtgtca tcattagaat gtcagatgtg   3300

cttctacgaa ctaagctgac tcttttaatt ctttggcaaa gggttggcaa actaggactg   3360

tttgccaaat tcaggctgcc tcctattttt agagtcttcc tgaaacacag ctacacccgt   3420

attatccatg gctgctttcc tgtcacagtg agtaagtagc tgggactgag aaggcatggc   3480

ctccaaagtc taaaatattt actctctagc actttgtaga aaaaccttag ctaggcacag   3540

tggctaacgc ctgtaatccc agcattttgg gaggccaagg caggcagatc acctgaggtc   3600

aggagttcca gaccagcctg gccaacatgg tgaaatccca tctctacaaa aataaaacag   3660

ttagctgggc atgatggcgg gtgcctgtaa tcccagctac tcgggaggct gaggcaggat   3720

agtcgcttga acccaggagg tggaggttgc aatgagccaa gatcatgcca ctgcactcca   3780

gcctggacga cagagtgaga ctccatcaca agaaaaaaag aactttgtca acctctgtct   3840

tagggcgcct tgtcacaggc ttcgggtcag acggattcaa ccttgcatca gccatttgtt   3900

agccaggtca ctctgttctt tgtctgtaaa tgagattgat cgttgttccc actgagagtg   3960

tcagctcctt cccgtagagc aggcatgatg attgtactca cctctgacac cattgtgagt   4020

gccacattcc ttcccacgtc cttgtcactg taagagatgc ccacctgagc accaacccca   4080

ggttatcttc ccctttgtct tccagccccc cagaaacagc tacgactcaa cctacccaat   4140

catttcatca tcagattgcc actgtctcta gttcaggtct cttgggactg gcactcagaa   4200

atctcataat aaatcctctt gaggcttctc atacactcgt cttcttccaa tcttctttcc   4260

ctcaaaatct catattttgg ttccacttca cccaccgtca ttctccatat cactcccagg   4320

agttaggcaa aaagcccctt ccgttcttcc gtatgttaaa cttagaatca ctctgttccc   4380

tgctctgcgt ttctattttt tgtttttcct ccatttacta gtagcttaac actttctaac   4440

agtgttctta ttattgatac gtatctatct cttccataag cttataaggt cacggataat   4500

acttctcatt gtagtacgta aatgacgtgg gctagatatg agttgaataa acagttatac   4560

ctgtaaattc ttacagagtg aaaataaatt gttatacttt acaatttgtt tctctcttta   4620

gaccatttcc aggacttgtg attaataacc gtgagtattt tgtgaagtgt tttgtttttg   4680

ttttttcctg gggtctgacg tgtgtgcgtg tgagtgtgta tacatgctta acgtatatca   4740

cgttacttca cctatgtcag taaccaggcc aaatacttgt tttagccctc agtaaaaaca   4800

ccaggcactt cctagttgta aaattattca agcttcttaa cttcctatcc tcgatgcact   4860

taatcataaa atggtaataa tagcaccgat tttgggggag tcgttccagt agatggaaag   4920

catctggaac aggtgtcagc aagctcctgc cgacgtgtat gcataaagtt ttattgaaac   4980

caccatcgtg tccatttgtt tatggcagaa ctgagagatg gcagcagcaa gtgtgtgcct   5040

gcaaaaccta aaatatttac taattggctc tgcaagaaaa gagtttgcat ccccctaacc   5100

tagaacagtg tctagcctct agtatgtgtt tagcctacag tatgtgctca gcgaatacaa   5160

tctatattta ttactgcttt tatgactgtt ataattactg tgcttggatt tcgttacaaa   5220

gtaagtcaca atgtgcctgc ttctgttagt atttcagcac agtgcctggc acacatgggg   5280

ctctcaaata ttgctgagcg agtgaacaaa tgtcctttca attccttaac gttgatgtca   5340

ttttcaatag tattttgagc caaacttaat tttgcgagtg tgttttgttt tcttaacttt   5400

attattaaaa atgtataaaa gtgaggccag gcgtggtggc tcacgcctgt aatcccagca   5460

gtttgggagg ctgaggcagg cggatcagtt gaggttggga gttggagacc agcccgtcca   5520

acatggtgaa agcctgtctc tactaaaaat acaaaaatca gctgggtgtg gtggcgcgtg   5580

cctgtaatcc cagctactca ggaggctgag gcaggagagt tgcttgaatc ctagaggtgg   5640

aggttgcagt gagctgagat cgtgccattg cactccagcc tgggcaacaa gagcaaaact   5700

ctgtcccaat aaataaataa ataaaatgtt ctcttttgtt cctgttcttg tgcggtagtg   5760

tggtatagag ttttatggta attactgtga attagtgatt ctgagggaca tatcagaact   5820

ctgaggtttg tttccttctc atcttgaggg aaacagcaaa tgtatgttaa aatgcttttc   5880

caagggaaca acacatcctt acattattta aaccaatctg cttcattttc agagctggtt   5940

gatcagagtg agtcagaagg ccccgtgata caagaatcag ctgaaccaag ccagttggaa   6000

gttccagcca cagaagaaat aaaagagact gatggaagct ctcagatcaa gcaagaacca   6060

gaccccacgt ggtagacctc ttccctccta gggtaaatca gcttctgtgt cagggatgct   6120

gtgtggtgtc catctgaacc ccctgcatac gcgtagctaa tgtgatctcc ccactttcac   6180

ataagatggt ggccctgcct tcagggaatg tgggagccag gtgggagcct tcccggatat   6240

ttaagctaga agattctaca gggagattct ccttggatca atatatgtct ctcagtcaaa   6300

gatgtaaaag cacttttgcc ttaaaaagaa tgttctgttt ctaaatagag tcaacgttgt   6360

cctcctcatt ggaattcact atgagtcaga atcattagac tgactttttt ttttccatag   6420

taatagtatt ttgcagagtc tcacagagct gcagatcttt tgttcatctt gcagagttaa   6480

caagtctgat cctgttagtc cagatttctt aaatttggcc aagttataat aggagcagta   6540

gcttgagacc cgaagtcagg aaactttgac aatggatttt tttttttaat ccagagactt   6600

gtactggaat ttgccttacc ctgtcagctc atggacttaa ggtttcatcc cgctttatga   6660

gtgcttctga atccaagtca ttgttacctg aatttgcaaa ttaagttgtg atattcgtga   6720

ctgttaaatt cctgtaatta gattaacctc tttgcttgct tgtttgtttt ctctcctatt   6780

ttagcttaaa gtatcagtgg ttgagaagag cttttcggac ctgttactac cccaagctgt   6840

gtaatatact tgtataacag aaataccttc tatacaaacc tttttttcta cttttagata   6900

gaaatgtcta ctttttcagc agttctgtga attaaagagc agagtgactg tgggtctgga   6960

atggctggtg tacttgggaa tgtactatca ggattttaca gcaatgctgg gaaatgacag   7020

ggaaaatgac aggaatgaat ctcaccagat tttttatgta ctcagcagag ccttgagtta   7080

cggtgtttat tttccaatca agtgaagata tctcctactt ctcctactgg aacatctcag   7140

cttctgcagt gaagaaaaat tcctgtgata gttcagttct ttagtttttc tatttgaaaa   7200

aaaaaaatca tttaaatgat cctttgttca cggctctcct taatgactga gtgaacagtt   7260

cctatctgta tatttgacta aaccttttcc taagctatct ctcatggttc ctatgttttt   7320

ttatcataat taaaagcaaa accatctgga tcacctaaca gtcagaggtc agtatctcag   7380

cgtgtgaatt atagaggaaa tacagagaga acctcttcca cttttacttt tcgtccaaat   7440

aaaatgcatg gtgtaccaga agttgaagat cgggttgagg attggggcta gctcgatgac   7500

actaaggccc caacatcgcg ggacctgctg tggcgcggat tcttaggaac gctgttctag   7560

ccggccccct ctccaggggt cgccgtggcc ggcattattt cctagttctt cttgtaaccc   7620

tgaggtgcca gcgcggggag tgaggagggg tcagggggct aaggatgcaa cctctgacgt   7680

tctgcgcctt cctaggagag tcttacatgt gttgagattt cacaagcaat gcgagttgta   7740

aaataccagc tctacaagaa gctaggctct gtgacggcat agttttcagt agctttatca   7800

caatattcac aatggagaat tatatgacat ggtagcagaa ataggccctt ttatgtgttg   7860

cttctatttt acctcaaatt gtagatatag ggtaatcaat aaaatccatc catgcctttc   7920

acacactaag t                                                        7931


<210>  4489
<211>  853
<212>  PRT
<213>  Homo sapiens

<400>  4489

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
465                 470                 475                 480


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
                485                 490                 495


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
            500                 505                 510


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
        515                 520                 525


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
    530                 535                 540


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
545                 550                 555                 560


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
                565                 570                 575


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
            580                 585                 590


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
        595                 600                 605


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
    610                 615                 620


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
625                 630                 635                 640


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
                645                 650                 655


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
            660                 665                 670


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
        675                 680                 685


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
    690                 695                 700


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
705                 710                 715                 720


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
                725                 730                 735


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
            740                 745                 750


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
        755                 760                 765


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
    770                 775                 780


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
785                 790                 795                 800


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
                805                 810                 815


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
            820                 825                 830


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
        835                 840                 845


Phe Thr Val Ile Arg 
    850


<210>  4490
<211>  7128
<212>  DNA
<213>  Homo sapiens

<400>  4490
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagctca agctcttgga ctcaccgagg   1980

cagtaaaagt accatatcct gtgtttgaat caaacccgga gttcttgtat gtggaaggct   2040

tgccagaggg gattcccttc cgaagcccta cctggtttgg aattccacga cttgaaagga   2100

tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa acctgaacta gttatttcct   2160

acttgcctcc tgggatggct agtaaaataa acactaaagc tttgcagtcc cccaaaagac   2220

cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta   2280

ataacaacaa tcctcaaacc tcagctgttc gaaccccgac ccagactaac ggttctaacg   2340

ttcccttcaa gccacgaggg agagagtttt cctttgaggc ctggaatgcc aaaatcacgg   2400

acctaaaaca gaaagttgaa aatctcttca atgagaaatg tggggaagct cttggcctta   2460

aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg   2520

aaggcttacc tgagggtgtg ccattccgaa gaccatcgac ttttggcatt ccgaggctgg   2580

agaagatact cagaaacaaa gccaaaatta agttcatcat taaaaagccc gaaatgtttg   2640

agacggcgat taaggagagc acctcctcta agagccctcc cagaaaaata aattcatcac   2700

ccaatgttaa tactactgca tcaggtgttg aagaccttaa catcattcag gtgacaattc   2760

cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta agagaacaag   2820

tgaatgacct ctttagtcgg aaatttggtg aagctattgg tatgggtttt cctgtgaaag   2880

ttccctacag gaaaatcaca attaaccctg gctgtgtggt ggttgatggc atgcccccgg   2940

gggtgtcctt caaagccccc agctacctgg aaatcagctc catgagaagg atcttagact   3000

ctgccgagtt tatcaaattc acggtcatta ggtaagtgag agtttcctgc ttagtcacag   3060

gagcgaatct ggagctcatg aggctgactc ttctaaaatg cagccacagg tagtcatcga   3120

atccggcttc ctatgctgtg caatcaacaa atcaaaataa cttgtgtcat cattagaatg   3180

tcagatgtgc ttctacgaac taagctgact cttttaattc tttggcaaag ggttggcaaa   3240

ctaggactgt ttgccaaatt caggctgcct cctattttta gagtcttcct gaaacacagc   3300

tacacccgta ttatccatgg ctgctttcct gtcacagtga gtaagtagct gggactgaga   3360

aggcatggcc tccaaagtct aaaatattta ctctctagca ctttgtagaa aaaccttagc   3420

taggcacagt ggctaacgcc tgtaatccca gcattttggg aggccaaggc aggcagatca   3480

cctgaggtca ggagttccag accagcctgg ccaacatggt gaaatcccat ctctacaaaa   3540

ataaaacagt tagctgggca tgatggcggg tgcctgtaat cccagctact cgggaggctg   3600

aggcaggata gtcgcttgaa cccaggaggt ggaggttgca atgagccaag atcatgccac   3660

tgcactccag cctggacgac agagtgagac tccatcacaa gaaaaaaaga actttgtcaa   3720

cctctgtctt agggcgcctt gtcacaggct tcgggtcaga cggattcaac cttgcatcag   3780

ccatttgtta gccaggtcac tctgttcttt gtctgtaaat gagattgatc gttgttccca   3840

ctgagagtgt cagctccttc ccgtagagca ggcatgatga ttgtactcac ctctgacacc   3900

attgtgagtg ccacattcct tcccacgtcc ttgtcactgt aagagatgcc cacctgagca   3960

ccaaccccag gttatcttcc cctttgtctt ccagcccccc agaaacagct acgactcaac   4020

ctacccaatc atttcatcat cagattgcca ctgtctctag ttcaggtctc ttgggactgg   4080

cactcagaaa tctcataata aatcctcttg aggcttctca tacactcgtc ttcttccaat   4140

cttctttccc tcaaaatctc atattttggt tccacttcac ccaccgtcat tctccatatc   4200

actcccagga gttaggcaaa aagccccttc cgttcttccg tatgttaaac ttagaatcac   4260

tctgttccct gctctgcgtt tctatttttt gtttttcctc catttactag tagcttaaca   4320

ctttctaaca gtgttcttat tattgatacg tatctatctc ttccataagc ttataaggtc   4380

acggataata cttctcattg tagtacgtaa atgacgtggg ctagatatga gttgaataaa   4440

cagttatacc tgtaaattct tacagagtga aaataaattg ttatacttta caatttgttt   4500

ctctctttag accatttcca ggacttgtga ttaataaccg tgagtatttt gtgaagtgtt   4560

ttgtttttgt tttttcctgg ggtctgacgt gtgtgcgtgt gagtgtgtat acatgcttaa   4620

cgtatatcac gttacttcac ctatgtcagt aaccaggcca aatacttgtt ttagccctca   4680

gtaaaaacac caggcacttc ctagttgtaa aattattcaa gcttcttaac ttcctatcct   4740

cgatgcactt aatcataaaa tggtaataat agcaccgatt ttgggggagt cgttccagta   4800

gatggaaagc atctggaaca ggtgtcagca agctcctgcc gacgtgtatg cataaagttt   4860

tattgaaacc accatcgtgt ccatttgttt atggcagaac tgagagatgg cagcagcaag   4920

tgtgtgcctg caaaacctaa aatatttact aattggctct gcaagaaaag agtttgcatc   4980

cccctaacct agaacagtgt ctagcctcta gtatgtgttt agcctacagt atgtgctcag   5040

cgaatacaat ctatatttat tactgctttt atgactgtta taattactgt gcttggattt   5100

cgttacaaag taagtcacaa tgtgcctgct tctgttagta tttcagcaca gtgcctggca   5160

cacatggggc tctcaaatat tgctgagcga gtgaacaaat gtcctttcaa ttccttaacg   5220

ttgatgtcat tttcaatagt attttgagcc aaacttaatt ttgcgagtgt gttttgtttt   5280

cttaacttta ttattaaaaa tgtataaaag tgaggccagg cgtggtggct cacgcctgta   5340

atcccagcag tttgggaggc tgaggcaggc ggatcagttg aggttgggag ttggagacca   5400

gcccgtccaa catggtgaaa gcctgtctct actaaaaata caaaaatcag ctgggtgtgg   5460

tggcgcgtgc ctgtaatccc agctactcag gaggctgagg caggagagtt gcttgaatcc   5520

tagaggtgga ggttgcagtg agctgagatc gtgccattgc actccagcct gggcaacaag   5580

agcaaaactc tgtcccaata aataaataaa taaaatgttc tcttttgttc ctgttcttgt   5640

gcggtagtgt ggtatagagt tttatggtaa ttactgtgaa ttagtgattc tgagggacat   5700

atcagaactc tgaggtttgt ttccttctca tcttgaggga aacagcaaat gtatgttaaa   5760

atgcttttcc aagggaacaa cacatcctta cattatttaa accaatctgc ttcattttca   5820

gagctggttg atcagagtga gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc   5880

cagttggaag ttccagccac agaagaaata aaagagactg atggaagctc tcagatcaag   5940

caagaaccag accccacgtg gtagacctct tccctcctag gcttaaagta tcagtggttg   6000

agaagagctt ttcggacctg ttactacccc aagctgtgta atatacttgt ataacagaaa   6060

taccttctat acaaaccttt ttttctactt ttagatagaa atgtctactt tttcagcagt   6120

tctgtgaatt aaagagcaga gtgactgtgg gtctggaatg gctggtgtac ttgggaatgt   6180

actatcagga ttttacagca atgctgggaa atgacaggga aaatgacagg aatgaatctc   6240

accagatttt ttatgtactc agcagagcct tgagttacgg tgtttatttt ccaatcaagt   6300

gaagatatct cctacttctc ctactggaac atctcagctt ctgcagtgaa gaaaaattcc   6360

tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct   6420

ttgttcacgg ctctccttaa tgactgagtg aacagttcct atctgtatat ttgactaaac   6480

cttttcctaa gctatctctc atggttccta tgttttttta tcataattaa aagcaaaacc   6540

atctggatca cctaacagtc agaggtcagt atctcagcgt gtgaattata gaggaaatac   6600

agagagaacc tcttccactt ttacttttcg tccaaataaa atgcatggtg taccagaagt   6660

tgaagatcgg gttgaggatt ggggctagct cgatgacact aaggccccaa catcgcggga   6720

cctgctgtgg cgcggattct taggaacgct gttctagccg gccccctctc caggggtcgc   6780

cgtggccggc attatttcct agttcttctt gtaaccctga ggtgccagcg cggggagtga   6840

ggaggggtca gggggctaag gatgcaacct ctgacgttct gcgccttcct aggagagtct   6900

tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa taccagctct acaagaagct   6960

aggctctgtg acggcatagt tttcagtagc tttatcacaa tattcacaat ggagaattat   7020

atgacatggt agcagaaata ggccctttta tgtgttgctt ctattttacc tcaaattgta   7080

gatatagggt aatcaataaa atccatccat gcctttcaca cactaagt                7128


<210>  4491
<211>  877
<212>  PRT
<213>  Homo sapiens

<400>  4491

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
        515                 520                 525


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
    530                 535                 540


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
545                 550                 555                 560


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
                565                 570                 575


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
            580                 585                 590


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
        595                 600                 605


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
    610                 615                 620


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
625                 630                 635                 640


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
                645                 650                 655


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
            660                 665                 670


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
        675                 680                 685


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
    690                 695                 700


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
705                 710                 715                 720


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
                725                 730                 735


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
            740                 745                 750


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
        755                 760                 765


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
    770                 775                 780


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
785                 790                 795                 800


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
                805                 810                 815


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
            820                 825                 830


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
        835                 840                 845


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
    850                 855                 860


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
865                 870                 875


<210>  4492
<211>  7216
<212>  DNA
<213>  Homo sapiens

<400>  4492
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2040

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2100

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2160

tgaatcaaac ccggagttct tgaaaggatc gtccgcggga gtaataaaat caagttcgtt   2220

gttaaaaaac ctgaactagt tatttcctac ttgcctcctg ggatggctag taaaataaac   2280

actaaagctt tgcagtcccc caaaagacca cgaagtcctg ggagtaattc aaaggttcct   2340

gaaattgagg tcaccgtgga aggccctaat aacaacaatc ctcaaacctc agctgttcga   2400

accccgaccc agactaacgg ttctaacgtt cccttcaagc cacgagggag agagttttcc   2460

tttgaggcct ggaatgccaa aatcacggac ctaaaacaga aagttgaaaa tctcttcaat   2520

gagaaatgtg gggaagctct tggccttaaa caagctgtga aggtgccgtt cgcgttattt   2580

gagtctttcc cggaagactt ttatgtggaa ggcttacctg agggtgtgcc attccgaaga   2640

ccatcgactt ttggcattcc gaggctggag aagatactca gaaacaaagc caaaattaag   2700

ttcatcatta aaaagcccga aatgtttgag acggcgatta aggagagcac ctcctctaag   2760

agccctccca gaaaaataaa ttcatcaccc aatgttaata ctactgcatc aggtgttgaa   2820

gaccttaaca tcattcaggt gacaattcca gatgatgata atgaaagact ctcgaaagtt   2880

gaaaaagcta gacagctaag agaacaagtg aatgacctct ttagtcggaa atttggtgaa   2940

gctattggta tgggttttcc tgtgaaagtt ccctacagga aaatcacaat taaccctggc   3000

tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca aagcccccag ctacctggaa   3060

atcagctcca tgagaaggat cttagactct gccgagttta tcaaattcac ggtcattagg   3120

taagtgagag tttcctgctt agtcacagga gcgaatctgg agctcatgag gctgactctt   3180

ctaaaatgca gccacaggta gtcatcgaat ccggcttcct atgctgtgca atcaacaaat   3240

caaaataact tgtgtcatca ttagaatgtc agatgtgctt ctacgaacta agctgactct   3300

tttaattctt tggcaaaggg ttggcaaact aggactgttt gccaaattca ggctgcctcc   3360

tatttttaga gtcttcctga aacacagcta cacccgtatt atccatggct gctttcctgt   3420

cacagtgagt aagtagctgg gactgagaag gcatggcctc caaagtctaa aatatttact   3480

ctctagcact ttgtagaaaa accttagcta ggcacagtgg ctaacgcctg taatcccagc   3540

attttgggag gccaaggcag gcagatcacc tgaggtcagg agttccagac cagcctggcc   3600

aacatggtga aatcccatct ctacaaaaat aaaacagtta gctgggcatg atggcgggtg   3660

cctgtaatcc cagctactcg ggaggctgag gcaggatagt cgcttgaacc caggaggtgg   3720

aggttgcaat gagccaagat catgccactg cactccagcc tggacgacag agtgagactc   3780

catcacaaga aaaaaagaac tttgtcaacc tctgtcttag ggcgccttgt cacaggcttc   3840

gggtcagacg gattcaacct tgcatcagcc atttgttagc caggtcactc tgttctttgt   3900

ctgtaaatga gattgatcgt tgttcccact gagagtgtca gctccttccc gtagagcagg   3960

catgatgatt gtactcacct ctgacaccat tgtgagtgcc acattccttc ccacgtcctt   4020

gtcactgtaa gagatgccca cctgagcacc aaccccaggt tatcttcccc tttgtcttcc   4080

agccccccag aaacagctac gactcaacct acccaatcat ttcatcatca gattgccact   4140

gtctctagtt caggtctctt gggactggca ctcagaaatc tcataataaa tcctcttgag   4200

gcttctcata cactcgtctt cttccaatct tctttccctc aaaatctcat attttggttc   4260

cacttcaccc accgtcattc tccatatcac tcccaggagt taggcaaaaa gccccttccg   4320

ttcttccgta tgttaaactt agaatcactc tgttccctgc tctgcgtttc tattttttgt   4380

ttttcctcca tttactagta gcttaacact ttctaacagt gttcttatta ttgatacgta   4440

tctatctctt ccataagctt ataaggtcac ggataatact tctcattgta gtacgtaaat   4500

gacgtgggct agatatgagt tgaataaaca gttatacctg taaattctta cagagtgaaa   4560

ataaattgtt atactttaca atttgtttct ctctttagac catttccagg acttgtgatt   4620

aataaccgtg agtattttgt gaagtgtttt gtttttgttt tttcctgggg tctgacgtgt   4680

gtgcgtgtga gtgtgtatac atgcttaacg tatatcacgt tacttcacct atgtcagtaa   4740

ccaggccaaa tacttgtttt agccctcagt aaaaacacca ggcacttcct agttgtaaaa   4800

ttattcaagc ttcttaactt cctatcctcg atgcacttaa tcataaaatg gtaataatag   4860

caccgatttt gggggagtcg ttccagtaga tggaaagcat ctggaacagg tgtcagcaag   4920

ctcctgccga cgtgtatgca taaagtttta ttgaaaccac catcgtgtcc atttgtttat   4980

ggcagaactg agagatggca gcagcaagtg tgtgcctgca aaacctaaaa tatttactaa   5040

ttggctctgc aagaaaagag tttgcatccc cctaacctag aacagtgtct agcctctagt   5100

atgtgtttag cctacagtat gtgctcagcg aatacaatct atatttatta ctgcttttat   5160

gactgttata attactgtgc ttggatttcg ttacaaagta agtcacaatg tgcctgcttc   5220

tgttagtatt tcagcacagt gcctggcaca catggggctc tcaaatattg ctgagcgagt   5280

gaacaaatgt cctttcaatt ccttaacgtt gatgtcattt tcaatagtat tttgagccaa   5340

acttaatttt gcgagtgtgt tttgttttct taactttatt attaaaaatg tataaaagtg   5400

aggccaggcg tggtggctca cgcctgtaat cccagcagtt tgggaggctg aggcaggcgg   5460

atcagttgag gttgggagtt ggagaccagc ccgtccaaca tggtgaaagc ctgtctctac   5520

taaaaataca aaaatcagct gggtgtggtg gcgcgtgcct gtaatcccag ctactcagga   5580

ggctgaggca ggagagttgc ttgaatccta gaggtggagg ttgcagtgag ctgagatcgt   5640

gccattgcac tccagcctgg gcaacaagag caaaactctg tcccaataaa taaataaata   5700

aaatgttctc ttttgttcct gttcttgtgc ggtagtgtgg tatagagttt tatggtaatt   5760

actgtgaatt agtgattctg agggacatat cagaactctg aggtttgttt ccttctcatc   5820

ttgagggaaa cagcaaatgt atgttaaaat gcttttccaa gggaacaaca catccttaca   5880

ttatttaaac caatctgctt cattttcaga gctggttgat cagagtgagt cagaaggccc   5940

cgtgatacaa gaatcagctg aaccaagcca gttggaagtt ccagccacag aagaaataaa   6000

agagactgat ggaagctctc agatcaagca agaaccagac cccacgtggt agacctcttc   6060

cctcctaggc ttaaagtatc agtggttgag aagagctttt cggacctgtt actaccccaa   6120

gctgtgtaat atacttgtat aacagaaata ccttctatac aaaccttttt ttctactttt   6180

agatagaaat gtctactttt tcagcagttc tgtgaattaa agagcagagt gactgtgggt   6240

ctggaatggc tggtgtactt gggaatgtac tatcaggatt ttacagcaat gctgggaaat   6300

gacagggaaa atgacaggaa tgaatctcac cagatttttt atgtactcag cagagccttg   6360

agttacggtg tttattttcc aatcaagtga agatatctcc tacttctcct actggaacat   6420

ctcagcttct gcagtgaaga aaaattcctg tgatagttca gttctttagt ttttctattt   6480

gaaaaaaaaa aatcatttaa atgatccttt gttcacggct ctccttaatg actgagtgaa   6540

cagttcctat ctgtatattt gactaaacct tttcctaagc tatctctcat ggttcctatg   6600

tttttttatc ataattaaaa gcaaaaccat ctggatcacc taacagtcag aggtcagtat   6660

ctcagcgtgt gaattataga ggaaatacag agagaacctc ttccactttt acttttcgtc   6720

caaataaaat gcatggtgta ccagaagttg aagatcgggt tgaggattgg ggctagctcg   6780

atgacactaa ggccccaaca tcgcgggacc tgctgtggcg cggattctta ggaacgctgt   6840

tctagccggc cccctctcca ggggtcgccg tggccggcat tatttcctag ttcttcttgt   6900

aaccctgagg tgccagcgcg gggagtgagg aggggtcagg gggctaagga tgcaacctct   6960

gacgttctgc gccttcctag gagagtctta catgtgttga gatttcacaa gcaatgcgag   7020

ttgtaaaata ccagctctac aagaagctag gctctgtgac ggcatagttt tcagtagctt   7080

tatcacaata ttcacaatgg agaattatat gacatggtag cagaaatagg cccttttatg   7140

tgttgcttct attttacctc aaattgtaga tatagggtaa tcaataaaat ccatccatgc   7200

ctttcacaca ctaagt                                                   7216


<210>  4493
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  4493

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala 
            580                 585                 590


Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600                 605


<210>  4494
<211>  4093
<212>  DNA
<213>  Homo sapiens

<400>  4494
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gtcaaagaag attggaatgt   1980

cagaattacc aagctacgga agcaagtgga agagattttt aatttgaaat ttgctcaagc   2040

tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt   2100

cttgaaagga tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa acctgaacta   2160

gttatttcct acttgcctcc tgggatggct agtaaaataa acactaaagc tttgcagtcc   2220

cccaaaagac cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg   2280

gaaggcccta ataacaacaa tcctcaaacc tcagctgttc gaaccccgac ccagactaac   2340

ggttctaacg ttcccttcaa gccacgaggg agagagtttt cctttgaggc ctggaatgcc   2400

aaaatcacgg acctaaaaca gaaagttgaa aatctcttca atgagaaatg tggggaagct   2460

cttggcctta aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac   2520

ttttatgtgg aaggcttacc tgagggtgtg ccattccgaa gaccatcgac ttttggcatt   2580

ccgaggctgg agaagatact cagaaacaaa gccaaaatta agttcatcat taaaaagccc   2640

gaaatgtttg agacggcgat taaggagagc acctcctcta agagccctcc cagaaaaata   2700

aattcatcac ccaatgttaa tactactgca tcaggtgttg aagaccttaa catcattcag   2760

gtgacaattc cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta   2820

agagaacaag tgaatgacct ctttagtcgg aaatttggtg aagctattgg tatgggtttt   2880

cctgtgaaag ttccctacag gaaaatcaca attaaccctg gctgtgtggt ggttgatggc   2940

atgcccccgg gggtgtcctt caaagccccc agctacctgg aaatcagctc catgagaagg   3000

atcttagact ctgccgagtt tatcaaattc acggtcatta gaccatttcc aggacttgtg   3060

attaataacc agctggttga tcagagtgag tcagaaggcc ccgtgataca agaatcagct   3120

gaaccaagcc agttggaagt tccagccaca gaagaaataa aagagactga tggaagctct   3180

cagatcaagc aagaaccaga ccccacgtgg tagacctctt ccctcctagg agccttgagt   3240

tacggtgttt attttccaat caagtgaaga tatctcctac ttctcctact ggaacatctc   3300

agcttctgca gtgaagaaaa attcctgtga tagttcagtt ctttagtttt tctatttgaa   3360

aaaaaaaaat catttaaatg atcctttgtt cacggctctc cttaatgact gagtgaacag   3420

ttcctatctg tatatttgac taaacctttt cctaagctat ctctcatggt tcctatgttt   3480

ttttatcata attaaaagca aaaccatctg gatcacctaa cagtcagagg tcagtatctc   3540

agcgtgtgaa ttatagagga aatacagaga gaacctcttc cacttttact tttcgtccaa   3600

ataaaatgca tggtgtacca gaagttgaag atcgggttga ggattggggc tagctcgatg   3660

acactaaggc cccaacatcg cgggacctgc tgtggcgcgg attcttagga acgctgttct   3720

agccggcccc ctctccaggg gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac   3780

cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc aacctctgac   3840

gttctgcgcc ttcctaggag agtcttacat gtgttgagat ttcacaagca atgcgagttg   3900

taaaatacca gctctacaag aagctaggct ctgtgacggc atagttttca gtagctttat   3960

cacaatattc acaatggaga attatatgac atggtagcag aaataggccc ttttatgtgt   4020

tgcttctatt ttacctcaaa ttgtagatat agggtaatca ataaaatcca tccatgcctt   4080

tcacacacta agt                                                      4093


<210>  4495
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  4495

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys 
                565                 570                 575


Asn Leu Asn 



<210>  4496
<211>  5306
<212>  DNA
<213>  Homo sapiens

<400>  4496
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   2040

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gcttagattt   2100

gttgacagcg gtttcctgga gtgctgtctt gagaacgatt ctgaggaggc tcagcaagaa   2160

agagtgtttc agttgattgg gtgtgtctgt catggagaag gaactcaagc tcttggactc   2220

accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgtatgtg   2280

gaaggcttgc cagaggggat tcccttccga agccctacct ggtttggaat tccacgactt   2340

gaaaggatcg tccgcgggag taataaaatc aagttcgttg ttaaaaaacc tgaactagtt   2400

atttcctact tgcctcctgg gatggctagt aaaataaaca ctaaagcttt gcagtccccc   2460

aaaagaccac gaagtcctgg gagtaattca aaggttcctg aaattgaggt caccgtggaa   2520

ggccctaata acaacaatcc tcaaacctca gctgttcgaa ccccgaccca gactaacggt   2580

tctaacgttc ccttcaagcc acgagggaga gagttttcct ttgaggcctg gaatgccaaa   2640

atcacggacc taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg ggaagctctt   2700

ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg agtctttccc ggaagacttt   2760

tatgtggaag gcttacctga gggtgtgcca ttccgaagac catcgacttt tggcattccg   2820

aggctggaga agatactcag aaacaaagcc aaaattaagt tcatcattaa aaagcccgaa   2880

atgtttgaga cggcgattaa ggagagcacc tcctctaaga gccctcccag aaaaataaat   2940

tcatcaccca atgttaatac tactgcatca ggtgttgaag accttaacat cattcaggtg   3000

acaattccag atgatgataa tgaaagactc tcgaaagttg aaaaagctag acagctaaga   3060

gaacaagtga atgacctctt tagtcggaaa tttggtgaag ctattggtat gggttttcct   3120

gtgaaagttc cctacaggaa aatcacaatt aaccctggct gtgtggtggt tgatggcatg   3180

cccccggggg tgtccttcaa agcccccagc tacctggaaa tcagctccat gagaaggatc   3240

ttagactctg ccgagtttat caaattcacg gtcattagac catttccagg acttgtgatt   3300

aataaccagc tggttgatca gagtgagtca gaaggccccg tgatacaaga atcagctgaa   3360

ccaagccagt tggaagttcc agccacagaa gaaataaaag agactgatgg aagctctcag   3420

atcaagcaag aaccagaccc cacgtggtag acctcttccc tcctagggta aatcagcttc   3480

tgtgtcaggg atgctgtgtg gtgtccatct gaaccccctg catacgcgta gctaatgtga   3540

tctccccact ttcacataag atggtggccc tgccttcagg gaatgtggga gccaggtggg   3600

agccttcccg gatatttaag ctagaagatt ctacagggag attctccttg gatcaatata   3660

tgtctctcag tcaaagatgt aaaagcactt ttgccttaaa aagaatgttc tgtttctaaa   3720

tagagtcaac gttgtcctcc tcattggaat tcactatgag tcagaatcat tagactgact   3780

tttttttttc catagtaata gtattttgca gagtctcaca gagctgcaga tcttttgttc   3840

atcttgcaga gttaacaagt ctgatcctgt tagtccagat ttcttaaatt tggccaagtt   3900

ataataggag cagtagcttg agacccgaag tcaggaaact ttgacaatgg attttttttt   3960

ttaatccaga gacttgtact ggaatttgcc ttaccctgtc agctcatgga cttaaggttt   4020

catcccgctt tatgagtgct tctgaatcca agtcattgtt acctgaattt gcaaattaag   4080

ttgtgatatt cgtgactgtt aaattcctgt aattagatta acctctttgc ttgcttgttt   4140

gttttctctc ctattttagc ttaaagtatc agtggttgag aagagctttt cggacctgtt   4200

actaccccaa gctgtgtaat atacttgtat aacagaaata ccttctatac aaaccttttt   4260

ttctactttt agatagaaat gtctactttt tcagcagttc tgtgaattaa agagcagagt   4320

gactgtgggt ctggaatggc tggtgtactt gggaatgtac tatcaggatt ttacagcaat   4380

gctgggaaat gacagggaaa atgacaggaa tgaatctcac cagatttttt atgtactcag   4440

cagagccttg agttacggtg tttattttcc aatcaagtga agatatctcc tacttctcct   4500

actggaacat ctcagcttct gcagtgaaga aaaattcctg tgatagttca gttctttagt   4560

ttttctattt gaaaaaaaaa aatcatttaa atgatccttt gttcacggct ctccttaatg   4620

actgagtgaa cagttcctat ctgtatattt gactaaacct tttcctaagc tatctctcat   4680

ggttcctatg tttttttatc ataattaaaa gcaaaaccat ctggatcacc taacagtcag   4740

aggtcagtat ctcagcgtgt gaattataga ggaaatacag agagaacctc ttccactttt   4800

acttttcgtc caaataaaat gcatggtgta ccagaagttg aagatcgggt tgaggattgg   4860

ggctagctcg atgacactaa ggccccaaca tcgcgggacc tgctgtggcg cggattctta   4920

ggaacgctgt tctagccggc cccctctcca ggggtcgccg tggccggcat tatttcctag   4980

ttcttcttgt aaccctgagg tgccagcgcg gggagtgagg aggggtcagg gggctaagga   5040

tgcaacctct gacgttctgc gccttcctag gagagtctta catgtgttga gatttcacaa   5100

gcaatgcgag ttgtaaaata ccagctctac aagaagctag gctctgtgac ggcatagttt   5160

tcagtagctt tatcacaata ttcacaatgg agaattatat gacatggtag cagaaatagg   5220

cccttttatg tgttgcttct attttacctc aaattgtaga tatagggtaa tcaataaaat   5280

ccatccatgc ctttcacaca ctaagt                                        5306


<210>  4497
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  4497

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala 



<210>  4498
<211>  7211
<212>  DNA
<213>  Homo sapiens

<400>  4498
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagc   2040

tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc   2100

ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc ctacctggtt   2160

tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa   2220

aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa taaacactaa   2280

agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg ttcctgaaat   2340

tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg ttcgaacccc   2400

gacccagact aacggttcta acgttccctt caagccacga gggagagagt tttcctttga   2460

ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct tcaatgagaa   2520

atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc   2580

tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc gaagaccatc   2640

gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa ttaagttcat   2700

cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct ctaagagccc   2760

tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg ttgaagacct   2820

taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga aagttgaaaa   2880

agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg gtgaagctat   2940

tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc ctggctgtgt   3000

ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc tggaaatcag   3060

ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca ttaggtaagt   3120

gagagtttcc tgcttagtca caggagcgaa tctggagctc atgaggctga ctcttctaaa   3180

atgcagccac aggtagtcat cgaatccggc ttcctatgct gtgcaatcaa caaatcaaaa   3240

taacttgtgt catcattaga atgtcagatg tgcttctacg aactaagctg actcttttaa   3300

ttctttggca aagggttggc aaactaggac tgtttgccaa attcaggctg cctcctattt   3360

ttagagtctt cctgaaacac agctacaccc gtattatcca tggctgcttt cctgtcacag   3420

tgagtaagta gctgggactg agaaggcatg gcctccaaag tctaaaatat ttactctcta   3480

gcactttgta gaaaaacctt agctaggcac agtggctaac gcctgtaatc ccagcatttt   3540

gggaggccaa ggcaggcaga tcacctgagg tcaggagttc cagaccagcc tggccaacat   3600

ggtgaaatcc catctctaca aaaataaaac agttagctgg gcatgatggc gggtgcctgt   3660

aatcccagct actcgggagg ctgaggcagg atagtcgctt gaacccagga ggtggaggtt   3720

gcaatgagcc aagatcatgc cactgcactc cagcctggac gacagagtga gactccatca   3780

caagaaaaaa agaactttgt caacctctgt cttagggcgc cttgtcacag gcttcgggtc   3840

agacggattc aaccttgcat cagccatttg ttagccaggt cactctgttc tttgtctgta   3900

aatgagattg atcgttgttc ccactgagag tgtcagctcc ttcccgtaga gcaggcatga   3960

tgattgtact cacctctgac accattgtga gtgccacatt ccttcccacg tccttgtcac   4020

tgtaagagat gcccacctga gcaccaaccc caggttatct tcccctttgt cttccagccc   4080

cccagaaaca gctacgactc aacctaccca atcatttcat catcagattg ccactgtctc   4140

tagttcaggt ctcttgggac tggcactcag aaatctcata ataaatcctc ttgaggcttc   4200

tcatacactc gtcttcttcc aatcttcttt ccctcaaaat ctcatatttt ggttccactt   4260

cacccaccgt cattctccat atcactccca ggagttaggc aaaaagcccc ttccgttctt   4320

ccgtatgtta aacttagaat cactctgttc cctgctctgc gtttctattt tttgtttttc   4380

ctccatttac tagtagctta acactttcta acagtgttct tattattgat acgtatctat   4440

ctcttccata agcttataag gtcacggata atacttctca ttgtagtacg taaatgacgt   4500

gggctagata tgagttgaat aaacagttat acctgtaaat tcttacagag tgaaaataaa   4560

ttgttatact ttacaatttg tttctctctt tagaccattt ccaggacttg tgattaataa   4620

ccgtgagtat tttgtgaagt gttttgtttt tgttttttcc tggggtctga cgtgtgtgcg   4680

tgtgagtgtg tatacatgct taacgtatat cacgttactt cacctatgtc agtaaccagg   4740

ccaaatactt gttttagccc tcagtaaaaa caccaggcac ttcctagttg taaaattatt   4800

caagcttctt aacttcctat cctcgatgca cttaatcata aaatggtaat aatagcaccg   4860

attttggggg agtcgttcca gtagatggaa agcatctgga acaggtgtca gcaagctcct   4920

gccgacgtgt atgcataaag ttttattgaa accaccatcg tgtccatttg tttatggcag   4980

aactgagaga tggcagcagc aagtgtgtgc ctgcaaaacc taaaatattt actaattggc   5040

tctgcaagaa aagagtttgc atccccctaa cctagaacag tgtctagcct ctagtatgtg   5100

tttagcctac agtatgtgct cagcgaatac aatctatatt tattactgct tttatgactg   5160

ttataattac tgtgcttgga tttcgttaca aagtaagtca caatgtgcct gcttctgtta   5220

gtatttcagc acagtgcctg gcacacatgg ggctctcaaa tattgctgag cgagtgaaca   5280

aatgtccttt caattcctta acgttgatgt cattttcaat agtattttga gccaaactta   5340

attttgcgag tgtgttttgt tttcttaact ttattattaa aaatgtataa aagtgaggcc   5400

aggcgtggtg gctcacgcct gtaatcccag cagtttggga ggctgaggca ggcggatcag   5460

ttgaggttgg gagttggaga ccagcccgtc caacatggtg aaagcctgtc tctactaaaa   5520

atacaaaaat cagctgggtg tggtggcgcg tgcctgtaat cccagctact caggaggctg   5580

aggcaggaga gttgcttgaa tcctagaggt ggaggttgca gtgagctgag atcgtgccat   5640

tgcactccag cctgggcaac aagagcaaaa ctctgtccca ataaataaat aaataaaatg   5700

ttctcttttg ttcctgttct tgtgcggtag tgtggtatag agttttatgg taattactgt   5760

gaattagtga ttctgaggga catatcagaa ctctgaggtt tgtttccttc tcatcttgag   5820

ggaaacagca aatgtatgtt aaaatgcttt tccaagggaa caacacatcc ttacattatt   5880

taaaccaatc tgcttcattt tcagagctgg ttgatcagag tgagtcagaa ggccccgtga   5940

tacaagaatc agctgaacca agccagttgg aagttccagc cacagaagaa ataaaagaga   6000

ctgatggaag ctctcagatc aagcaagaac cagaccccac gtggtagacc tcttccctcc   6060

taggcttaaa gtatcagtgg ttgagaagag cttttcggac ctgttactac cccaagctgt   6120

gtaatatact tgtataacag aaataccttc tatacaaacc tttttttcta cttttagata   6180

gaaatgtcta ctttttcagc agttctgtga attaaagagc agagtgactg tgggtctgga   6240

atggctggtg tacttgggaa tgtactatca ggattttaca gcaatgctgg gaaatgacag   6300

ggaaaatgac aggaatgaat ctcaccagat tttttatgta ctcagcagag ccttgagtta   6360

cggtgtttat tttccaatca agtgaagata tctcctactt ctcctactgg aacatctcag   6420

cttctgcagt gaagaaaaat tcctgtgata gttcagttct ttagtttttc tatttgaaaa   6480

aaaaaaatca tttaaatgat cctttgttca cggctctcct taatgactga gtgaacagtt   6540

cctatctgta tatttgacta aaccttttcc taagctatct ctcatggttc ctatgttttt   6600

ttatcataat taaaagcaaa accatctgga tcacctaaca gtcagaggtc agtatctcag   6660

cgtgtgaatt atagaggaaa tacagagaga acctcttcca cttttacttt tcgtccaaat   6720

aaaatgcatg gtgtaccaga agttgaagat cgggttgagg attggggcta gctcgatgac   6780

actaaggccc caacatcgcg ggacctgctg tggcgcggat tcttaggaac gctgttctag   6840

ccggccccct ctccaggggt cgccgtggcc ggcattattt cctagttctt cttgtaaccc   6900

tgaggtgcca gcgcggggag tgaggagggg tcagggggct aaggatgcaa cctctgacgt   6960

tctgcgcctt cctaggagag tcttacatgt gttgagattt cacaagcaat gcgagttgta   7020

aaataccagc tctacaagaa gctaggctct gtgacggcat agttttcagt agctttatca   7080

caatattcac aatggagaat tatatgacat ggtagcagaa ataggccctt ttatgtgttg   7140

cttctatttt acctcaaatt gtagatatag ggtaatcaat aaaatccatc catgcctttc   7200

acacactaag t                                                        7211


<210>  4499
<211>  898
<212>  PRT
<213>  Homo sapiens

<400>  4499

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly 
    530                 535                 540


Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro 
545                 550                 555                 560


Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser 
                565                 570                 575


Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser 
            580                 585                 590


Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr 
        595                 600                 605


Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser 
    610                 615                 620


Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile 
625                 630                 635                 640


Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala 
                645                 650                 655


Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro 
            660                 665                 670


Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp 
        675                 680                 685


Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala 
    690                 695                 700


Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser 
705                 710                 715                 720


Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe 
                725                 730                 735


Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg 
            740                 745                 750


Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu 
        755                 760                 765


Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile 
    770                 775                 780


Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu 
785                 790                 795                 800


Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser 
                805                 810                 815


Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe 
            820                 825                 830


Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val 
        835                 840                 845


Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly 
    850                 855                 860


Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser 
865                 870                 875                 880


Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val 
                885                 890                 895


Ile Arg 



<210>  4500
<211>  4120
<212>  DNA
<213>  Homo sapiens

<400>  4500
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1980

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   2040

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   2100

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2160

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2220

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2280

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2340

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2400

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2460

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2520

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2580

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2640

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2700

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2760

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2820

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2880

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2940

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   3000

cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg atcagagtga   3060

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   3120

agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag accccacgtg   3180

gtagacctct tccctcctag gcttaaagta tcagtggttg agaagagctt ttcggacctg   3240

ttactacccc aagctgtagc cttgagttac ggtgtttatt ttccaatcaa gtgaagatat   3300

ctcctacttc tcctactgga acatctcagc ttctgcagtg aagaaaaatt cctgtgatag   3360

ttcagttctt tagtttttct atttgaaaaa aaaaaatcat ttaaatgatc ctttgttcac   3420

ggctctcctt aatgactgag tgaacagttc ctatctgtat atttgactaa accttttcct   3480

aagctatctc tcatggttcc tatgtttttt tatcataatt aaaagcaaaa ccatctggat   3540

cacctaacag tcagaggtca gtatctcagc gtgtgaatta tagaggaaat acagagagaa   3600

cctcttccac ttttactttt cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc   3660

gggttgagga ttggggctag ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt   3720

ggcgcggatt cttaggaacg ctgttctagc cggccccctc tccaggggtc gccgtggccg   3780

gcattatttc ctagttcttc ttgtaaccct gaggtgccag cgcggggagt gaggaggggt   3840

cagggggcta aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg   3900

ttgagatttc acaagcaatg cgagttgtaa aataccagct ctacaagaag ctaggctctg   3960

tgacggcata gttttcagta gctttatcac aatattcaca atggagaatt atatgacatg   4020

gtagcagaaa taggcccttt tatgtgttgc ttctatttta cctcaaattg tagatatagg   4080

gtaatcaata aaatccatcc atgcctttca cacactaagt                         4120


<210>  4501
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  4501

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
    450                 455                 460


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
465                 470                 475                 480


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
                485                 490                 495


Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys 
            500                 505                 510


Asn Leu Asn 
        515


<210>  4502
<211>  5183
<212>  DNA
<213>  Homo sapiens

<400>  4502
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1920

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct tagatttgtt   1980

gacagcggtt tcctggagtg ctgtcttgag aacgattctg aggaggctca gcaagaaaga   2040

gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa ctcaagctct tggactcacc   2100

gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc cggagttctt gtatgtggaa   2160

ggcttgccag aggggattcc cttccgaagc cctacctggt ttggaattcc acgacttgaa   2220

aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta aaaaacctga actagttatt   2280

tcctacttgc ctcctgggat ggctagtaaa ataaacacta aagctttgca gtcccccaaa   2340

agaccacgaa gtcctgggag taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc   2400

cctaataaca acaatcctca aacctcagct gttcgaaccc cgacccagac taacggttct   2460

aacgttccct tcaagccacg agggagagag ttttcctttg aggcctggaa tgccaaaatc   2520

acggacctaa aacagaaagt tgaaaatctc ttcaatgaga aatgtgggga agctcttggc   2580

cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt ctttcccgga agacttttat   2640

gtggaaggct tacctgaggg tgtgccattc cgaagaccat cgacttttgg cattccgagg   2700

ctggagaaga tactcagaaa caaagccaaa attaagttca tcattaaaaa gcccgaaatg   2760

tttgagacgg cgattaagga gagcacctcc tctaagagcc ctcccagaaa aataaattca   2820

tcacccaatg ttaatactac tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca   2880

attccagatg atgataatga aagactctcg aaagttgaaa aagctagaca gctaagagaa   2940

caagtgaatg acctctttag tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg   3000

aaagttccct acaggaaaat cacaattaac cctggctgtg tggtggttga tggcatgccc   3060

ccgggggtgt ccttcaaagc ccccagctac ctggaaatca gctccatgag aaggatctta   3120

gactctgccg agtttatcaa attcacggtc attagaccat ttccaggact tgtgattaat   3180

aaccagctgg ttgatcagag tgagtcagaa ggccccgtga tacaagaatc agctgaacca   3240

agccagttgg aagttccagc cacagaagaa ataaaagaga ctgatggaag ctctcagatc   3300

aagcaagaac cagaccccac gtggtagacc tcttccctcc tagggtaaat cagcttctgt   3360

gtcagggatg ctgtgtggtg tccatctgaa ccccctgcat acgcgtagct aatgtgatct   3420

ccccactttc acataagatg gtggccctgc cttcagggaa tgtgggagcc aggtgggagc   3480

cttcccggat atttaagcta gaagattcta cagggagatt ctccttggat caatatatgt   3540

ctctcagtca aagatgtaaa agcacttttg ccttaaaaag aatgttctgt ttctaaatag   3600

agtcaacgtt gtcctcctca ttggaattca ctatgagtca gaatcattag actgactttt   3660

ttttttccat agtaatagta ttttgcagag tctcacagag ctgcagatct tttgttcatc   3720

ttgcagagtt aacaagtctg atcctgttag tccagatttc ttaaatttgg ccaagttata   3780

ataggagcag tagcttgaga cccgaagtca ggaaactttg acaatggatt ttttttttta   3840

atccagagac ttgtactgga atttgcctta ccctgtcagc tcatggactt aaggtttcat   3900

cccgctttat gagtgcttct gaatccaagt cattgttacc tgaatttgca aattaagttg   3960

tgatattcgt gactgttaaa ttcctgtaat tagattaacc tctttgcttg cttgtttgtt   4020

ttctctccta ttttagctta aagtatcagt ggttgagaag agcttttcgg acctgttact   4080

accccaagct gtgtaatata cttgtataac agaaatacct tctatacaaa cctttttttc   4140

tacttttaga tagaaatgtc tactttttca gcagttctgt gaattaaaga gcagagtgac   4200

tgtgggtctg gaatggctgg tgtacttggg aatgtactat caggatttta cagcaatgct   4260

gggaaatgac agggaaaatg acaggaatga atctcaccag attttttatg tactcagcag   4320

agccttgagt tacggtgttt attttccaat caagtgaaga tatctcctac ttctcctact   4380

ggaacatctc agcttctgca gtgaagaaaa attcctgtga tagttcagtt ctttagtttt   4440

tctatttgaa aaaaaaaaat catttaaatg atcctttgtt cacggctctc cttaatgact   4500

gagtgaacag ttcctatctg tatatttgac taaacctttt cctaagctat ctctcatggt   4560

tcctatgttt ttttatcata attaaaagca aaaccatctg gatcacctaa cagtcagagg   4620

tcagtatctc agcgtgtgaa ttatagagga aatacagaga gaacctcttc cacttttact   4680

tttcgtccaa ataaaatgca tggtgtacca gaagttgaag atcgggttga ggattggggc   4740

tagctcgatg acactaaggc cccaacatcg cgggacctgc tgtggcgcgg attcttagga   4800

acgctgttct agccggcccc ctctccaggg gtcgccgtgg ccggcattat ttcctagttc   4860

ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc   4920

aacctctgac gttctgcgcc ttcctaggag agtcttacat gtgttgagat ttcacaagca   4980

atgcgagttg taaaatacca gctctacaag aagctaggct ctgtgacggc atagttttca   5040

gtagctttat cacaatattc acaatggaga attatatgac atggtagcag aaataggccc   5100

ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat agggtaatca ataaaatcca   5160

tccatgcctt tcacacacta agt                                           5183


<210>  4503
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  4503

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
            500                 505                 510


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
        515                 520


<210>  4504
<211>  4392
<212>  DNA
<213>  Homo sapiens

<400>  4504
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   1980

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2040

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2100

atcaaacccg gagttcttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2160

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2220

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2280

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2340

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2400

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2460

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2520

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2580

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2640

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2700

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2760

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2820

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2880

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   2940

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3000

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca   3060

tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg   3120

atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag   3180

actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc   3240

ctaggcttaa agtatcagtg gttgagaaga gcttttcgga cctgttacta ccccaagctg   3300

tgtaatatac ttgtataaca gaaatacctt ctatacaaac ctttttttct acttttagat   3360

agaaatgtct actttttcag cagttctgtg aattaaagag cagagtgact gtgggtctgg   3420

aatggctggt gtacttggga atgtactatc aggattttac agcaatgctg ggaaatgaca   3480

gggaaaatga caggaatgaa tctcaccaga ttttttatgt actcagcaga gccttgagtt   3540

acggtgttta ttttccaatc aagtgaagat atctcctact tctcctactg gaacatctca   3600

gcttctgcag tgaagaaaaa ttcctgtgat agttcagttc tttagttttt ctatttgaaa   3660

aaaaaaaatc atttaaatga tcctttgttc acggctctcc ttaatgactg agtgaacagt   3720

tcctatctgt atatttgact aaaccttttc ctaagctatc tctcatggtt cctatgtttt   3780

tttatcataa ttaaaagcaa aaccatctgg atcacctaac agtcagaggt cagtatctca   3840

gcgtgtgaat tatagaggaa atacagagag aacctcttcc acttttactt ttcgtccaaa   3900

taaaatgcat ggtgtaccag aagttgaaga tcgggttgag gattggggct agctcgatga   3960

cactaaggcc ccaacatcgc gggacctgct gtggcgcgga ttcttaggaa cgctgttcta   4020

gccggccccc tctccagggg tcgccgtggc cggcattatt tcctagttct tcttgtaacc   4080

ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc taaggatgca acctctgacg   4140

ttctgcgcct tcctaggaga gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt   4200

aaaataccag ctctacaaga agctaggctc tgtgacggca tagttttcag tagctttatc   4260

acaatattca caatggagaa ttatatgaca tggtagcaga aataggccct tttatgtgtt   4320

gcttctattt tacctcaaat tgtagatata gggtaatcaa taaaatccat ccatgccttt   4380

cacacactaa gt                                                       4392


<210>  4505
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  4505

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
                565                 570                 575


Ser Ser Leu Leu Lys Asn Leu Asn 
            580


<210>  4506
<211>  5263
<212>  DNA
<213>  Homo sapiens

<400>  4506
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   1980

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2040

gaaatttgct tagatttgtt gacagcggtt tcctggagtg ctgtcttgag aacgattctg   2100

aggaggctca gcaagaaaga gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa   2160

ctcaagctct tggactcacc gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc   2220

cggagttctt gtatgtggaa ggcttgccag aggggattcc cttccgaagc cctacctggt   2280

ttggaattcc acgacttgaa aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta   2340

aaaaacctga actagttatt tcctacttgc ctcctgggat ggctagtaaa ataaacacta   2400

aagctttgca gtcccccaaa agaccacgaa gtcctgggag taattcaaag gttcctgaaa   2460

ttgaggtcac cgtggaaggc cctaataaca acaatcctca aacctcagct gttcgaaccc   2520

cgacccagac taacggttct aacgttccct tcaagccacg agggagagag ttttcctttg   2580

aggcctggaa tgccaaaatc acggacctaa aacagaaagt tgaaaatctc ttcaatgaga   2640

aatgtgggga agctcttggc cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt   2700

ctttcccgga agacttttat gtggaaggct tacctgaggg tgtgccattc cgaagaccat   2760

cgacttttgg cattccgagg ctggagaaga tactcagaaa caaagccaaa attaagttca   2820

tcattaaaaa gcccgaaatg tttgagacgg cgattaagga gagcacctcc tctaagagcc   2880

ctcccagaaa aataaattca tcacccaatg ttaatactac tgcatcaggt gttgaagacc   2940

ttaacatcat tcaggtgaca attccagatg atgataatga aagactctcg aaagttgaaa   3000

aagctagaca gctaagagaa caagtgaatg acctctttag tcggaaattt ggtgaagcta   3060

ttggtatggg ttttcctgtg aaagttccct acaggaaaat cacaattaac cctggctgtg   3120

tggtggttga tggcatgccc ccgggggtgt ccttcaaagc ccccagctac ctggaaatca   3180

gctccatgag aaggatctta gactctgccg agtttatcaa attcacggtc attagaccat   3240

ttccaggact tgtgattaat aaccagctgg ttgatcagag tgagtcagaa ggccccgtga   3300

tacaagaatc agctgaacca agccagttgg aagttccagc cacagaagaa ataaaagaga   3360

ctgatggaag ctctcagatc aagcaagaac cagaccccac gtggtagacc tcttccctcc   3420

tagggtaaat cagcttctgt gtcagggatg ctgtgtggtg tccatctgaa ccccctgcat   3480

acgcgtagct aatgtgatct ccccactttc acataagatg gtggccctgc cttcagggaa   3540

tgtgggagcc aggtgggagc cttcccggat atttaagcta gaagattcta cagggagatt   3600

ctccttggat caatatatgt ctctcagtca aagatgtaaa agcacttttg ccttaaaaag   3660

aatgttctgt ttctaaatag agtcaacgtt gtcctcctca ttggaattca ctatgagtca   3720

gaatcattag actgactttt ttttttccat agtaatagta ttttgcagag tctcacagag   3780

ctgcagatct tttgttcatc ttgcagagtt aacaagtctg atcctgttag tccagatttc   3840

ttaaatttgg ccaagttata ataggagcag tagcttgaga cccgaagtca ggaaactttg   3900

acaatggatt ttttttttta atccagagac ttgtactgga atttgcctta ccctgtcagc   3960

tcatggactt aaggtttcat cccgctttat gagtgcttct gaatccaagt cattgttacc   4020

tgaatttgca aattaagttg tgatattcgt gactgttaaa ttcctgtaat tagattaacc   4080

tctttgcttg cttgtttgtt ttctctccta ttttagctta aagtatcagt ggttgagaag   4140

agcttttcgg acctgttact accccaagct gtgtaatata cttgtataac agaaatacct   4200

tctatacaaa cctttttttc tacttttaga tagaaatgtc tactttttca gcagttctgt   4260

gaattaaaga gcagagtgac tgtgggtctg gaatggctgg tgtacttggg aatgtactat   4320

caggatttta cagcaatgct gggaaatgac agggaaaatg acaggaatga atctcaccag   4380

attttttatg tactcagcag agccttgagt tacggtgttt attttccaat caagtgaaga   4440

tatctcctac ttctcctact ggaacatctc agcttctgca gtgaagaaaa attcctgtga   4500

tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat catttaaatg atcctttgtt   4560

cacggctctc cttaatgact gagtgaacag ttcctatctg tatatttgac taaacctttt   4620

cctaagctat ctctcatggt tcctatgttt ttttatcata attaaaagca aaaccatctg   4680

gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa ttatagagga aatacagaga   4740

gaacctcttc cacttttact tttcgtccaa ataaaatgca tggtgtacca gaagttgaag   4800

atcgggttga ggattggggc tagctcgatg acactaaggc cccaacatcg cgggacctgc   4860

tgtggcgcgg attcttagga acgctgttct agccggcccc ctctccaggg gtcgccgtgg   4920

ccggcattat ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg   4980

ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc ttcctaggag agtcttacat   5040

gtgttgagat ttcacaagca atgcgagttg taaaatacca gctctacaag aagctaggct   5100

ctgtgacggc atagttttca gtagctttat cacaatattc acaatggaga attatatgac   5160

atggtagcag aaataggccc ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat   5220

agggtaatca ataaaatcca tccatgcctt tcacacacta agt                     5263


<210>  4507
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  4507

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  4508
<211>  5168
<212>  DNA
<213>  Homo sapiens

<400>  4508
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gtcaaagaag attggaatgt cagaattacc aagctacgga   1920

agcaagtgga agagattttt aatttgaaat ttgcttagat ttgttgacag cggtttcctg   1980

gagtgctgtc ttgagaacga ttctgaggag gctcagcaag aaagagtgtt tcagttgatt   2040

gggtgtgtct gtcatggaga aggaactcaa gctcttggac tcaccgaggc agtaaaagta   2100

ccatatcctg tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg   2160

attcccttcc gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg   2220

agtaataaaa tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct   2280

gggatggcta gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct   2340

gggagtaatt caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat   2400

cctcaaacct cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag   2460

ccacgaggga gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag   2520

aaagttgaaa atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg   2580

aaggtgccgt tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct   2640

gagggtgtgc cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc   2700

agaaacaaag ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt   2760

aaggagagca cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat   2820

actactgcat caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat   2880

aatgaaagac tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc   2940

tttagtcgga aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg   3000

aaaatcacaa ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc   3060

aaagccccca gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt   3120

atcaaattca cggtcattag accatttcca ggacttgtga ttaataacca gctggttgat   3180

cagagtgagt cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt   3240

ccagccacag aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac   3300

cccacgtggt agacctcttc cctcctaggg taaatcagct tctgtgtcag ggatgctgtg   3360

tggtgtccat ctgaaccccc tgcatacgcg tagctaatgt gatctcccca ctttcacata   3420

agatggtggc cctgccttca gggaatgtgg gagccaggtg ggagccttcc cggatattta   3480

agctagaaga ttctacaggg agattctcct tggatcaata tatgtctctc agtcaaagat   3540

gtaaaagcac ttttgcctta aaaagaatgt tctgtttcta aatagagtca acgttgtcct   3600

cctcattgga attcactatg agtcagaatc attagactga cttttttttt tccatagtaa   3660

tagtattttg cagagtctca cagagctgca gatcttttgt tcatcttgca gagttaacaa   3720

gtctgatcct gttagtccag atttcttaaa tttggccaag ttataatagg agcagtagct   3780

tgagacccga agtcaggaaa ctttgacaat ggattttttt ttttaatcca gagacttgta   3840

ctggaatttg ccttaccctg tcagctcatg gacttaaggt ttcatcccgc tttatgagtg   3900

cttctgaatc caagtcattg ttacctgaat ttgcaaatta agttgtgata ttcgtgactg   3960

ttaaattcct gtaattagat taacctcttt gcttgcttgt ttgttttctc tcctatttta   4020

gcttaaagta tcagtggttg agaagagctt ttcggacctg ttactacccc aagctgtgta   4080

atatacttgt ataacagaaa taccttctat acaaaccttt ttttctactt ttagatagaa   4140

atgtctactt tttcagcagt tctgtgaatt aaagagcaga gtgactgtgg gtctggaatg   4200

gctggtgtac ttgggaatgt actatcagga ttttacagca atgctgggaa atgacaggga   4260

aaatgacagg aatgaatctc accagatttt ttatgtactc agcagagcct tgagttacgg   4320

tgtttatttt ccaatcaagt gaagatatct cctacttctc ctactggaac atctcagctt   4380

ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa   4440

aaaatcattt aaatgatcct ttgttcacgg ctctccttaa tgactgagtg aacagttcct   4500

atctgtatat ttgactaaac cttttcctaa gctatctctc atggttccta tgttttttta   4560

tcataattaa aagcaaaacc atctggatca cctaacagtc agaggtcagt atctcagcgt   4620

gtgaattata gaggaaatac agagagaacc tcttccactt ttacttttcg tccaaataaa   4680

atgcatggtg taccagaagt tgaagatcgg gttgaggatt ggggctagct cgatgacact   4740

aaggccccaa catcgcggga cctgctgtgg cgcggattct taggaacgct gttctagccg   4800

gccccctctc caggggtcgc cgtggccggc attatttcct agttcttctt gtaaccctga   4860

ggtgccagcg cggggagtga ggaggggtca gggggctaag gatgcaacct ctgacgttct   4920

gcgccttcct aggagagtct tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa   4980

taccagctct acaagaagct aggctctgtg acggcatagt tttcagtagc tttatcacaa   5040

tattcacaat ggagaattat atgacatggt agcagaaata ggccctttta tgtgttgctt   5100

ctattttacc tcaaattgta gatatagggt aatcaataaa atccatccat gcctttcaca   5160

cactaagt                                                            5168


<210>  4509
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  4509

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
                485                 490                 495


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
            500                 505                 510


Phe Asn Leu Lys Phe Ala 
        515


<210>  4510
<211>  3890
<212>  DNA
<213>  Homo sapiens

<400>  4510
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   1980

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2040

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2100

tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg tttggaattc   2160

cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg   2220

aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc   2280

agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca   2340

ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga   2400

ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga   2460

atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg   2520

aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg   2580

aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg   2640

gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa   2700

agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa   2760

aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca   2820

ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac   2880

agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg   2940

gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg   3000

atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga   3060

gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca tttccaggac   3120

ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat   3180

cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa   3240

gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc ctaggcaaaa   3300

ccatctggat cacctaacag tcagaggtca gtatctcagc gtgtgaatta tagaggaaat   3360

acagagagaa cctcttccac ttttactttt cgtccaaata aaatgcatgg tgtaccagaa   3420

gttgaagatc gggttgagga ttggggctag ctcgatgaca ctaaggcccc aacatcgcgg   3480

gacctgctgt ggcgcggatt cttaggaacg ctgttctagc cggccccctc tccaggggtc   3540

gccgtggccg gcattatttc ctagttcttc ttgtaaccct gaggtgccag cgcggggagt   3600

gaggaggggt cagggggcta aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt   3660

cttacatgtg ttgagatttc acaagcaatg cgagttgtaa aataccagct ctacaagaag   3720

ctaggctctg tgacggcata gttttcagta gctttatcac aatattcaca atggagaatt   3780

atatgacatg gtagcagaaa taggcccttt tatgtgttgc ttctatttta cctcaaattg   3840

tagatatagg gtaatcaata aaatccatcc atgcctttca cacactaagt              3890


<210>  4511
<211>  958
<212>  PRT
<213>  Homo sapiens

<400>  4511

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile 
        515                 520                 525


Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
545                 550                 555                 560


Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile 
                565                 570                 575


Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile 
            580                 585                 590


Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu 
        595                 600                 605


Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys 
    610                 615                 620


Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys 
625                 630                 635                 640


Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro 
                645                 650                 655


Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val 
            660                 665                 670


Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala 
        675                 680                 685


Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys 
    690                 695                 700


Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala 
705                 710                 715                 720


Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu 
                725                 730                 735


Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu 
            740                 745                 750


Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro 
        755                 760                 765


Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro 
    770                 775                 780


Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly 
785                 790                 795                 800


Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn 
                805                 810                 815


Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val 
            820                 825                 830


Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe 
        835                 840                 845


Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val 
    850                 855                 860


Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr 
865                 870                 875                 880


Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile 
                885                 890                 895


Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln 
            900                 905                 910


Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala 
        915                 920                 925


Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr 
    930                 935                 940


Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950                 955


<210>  4512
<211>  5093
<212>  DNA
<213>  Homo sapiens

<400>  4512
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1860

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1920

tgaaatttgc ttagatttgt tgacagcggt ttcctggagt gctgtcttga gaacgattct   1980

gaggaggctc agcaagaaag agtgtttcag ttgattgggt gtgtctgtca tggagaagga   2040

actcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac   2100

ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg   2160

tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2220

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2280

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2340

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2400

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2460

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2520

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2580

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2640

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2700

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2760

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2820

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2880

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2940

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   3000

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3060

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca   3120

tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg   3180

atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaagg taaaaggacc   3240

tcttccctcc tagggtaaat cagcttctgt gtcagggatg ctgtgtggtg tccatctgaa   3300

ccccctgcat acgcgtagct aatgtgatct ccccactttc acataagatg gtggccctgc   3360

cttcagggaa tgtgggagcc aggtgggagc cttcccggat atttaagcta gaagattcta   3420

cagggagatt ctccttggat caatatatgt ctctcagtca aagatgtaaa agcacttttg   3480

ccttaaaaag aatgttctgt ttctaaatag agtcaacgtt gtcctcctca ttggaattca   3540

ctatgagtca gaatcattag actgactttt ttttttccat agtaatagta ttttgcagag   3600

tctcacagag ctgcagatct tttgttcatc ttgcagagtt aacaagtctg atcctgttag   3660

tccagatttc ttaaatttgg ccaagttata ataggagcag tagcttgaga cccgaagtca   3720

ggaaactttg acaatggatt ttttttttta atccagagac ttgtactgga atttgcctta   3780

ccctgtcagc tcatggactt aaggtttcat cccgctttat gagtgcttct gaatccaagt   3840

cattgttacc tgaatttgca aattaagttg tgatattcgt gactgttaaa ttcctgtaat   3900

tagattaacc tctttgcttg cttgtttgtt ttctctccta ttttagctta aagtatcagt   3960

ggttgagaag agcttttcgg acctgttact accccaagct gtgtaatata cttgtataac   4020

agaaatacct tctatacaaa cctttttttc tacttttaga tagaaatgtc tactttttca   4080

gcagttctgt gaattaaaga gcagagtgac tgtgggtctg gaatggctgg tgtacttggg   4140

aatgtactat caggatttta cagcaatgct gggaaatgac agggaaaatg acaggaatga   4200

atctcaccag attttttatg tactcagcag agccttgagt tacggtgttt attttccaat   4260

caagtgaaga tatctcctac ttctcctact ggaacatctc agcttctgca gtgaagaaaa   4320

attcctgtga tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat catttaaatg   4380

atcctttgtt cacggctctc cttaatgact gagtgaacag ttcctatctg tatatttgac   4440

taaacctttt cctaagctat ctctcatggt tcctatgttt ttttatcata attaaaagca   4500

aaaccatctg gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa ttatagagga   4560

aatacagaga gaacctcttc cacttttact tttcgtccaa ataaaatgca tggtgtacca   4620

gaagttgaag atcgggttga ggattggggc tagctcgatg acactaaggc cccaacatcg   4680

cgggacctgc tgtggcgcgg attcttagga acgctgttct agccggcccc ctctccaggg   4740

gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg   4800

agtgaggagg ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc ttcctaggag   4860

agtcttacat gtgttgagat ttcacaagca atgcgagttg taaaatacca gctctacaag   4920

aagctaggct ctgtgacggc atagttttca gtagctttat cacaatattc acaatggaga   4980

attatatgac atggtagcag aaataggccc ttttatgtgt tgcttctatt ttacctcaaa   5040

ttgtagatat agggtaatca ataaaatcca tccatgcctt tcacacacta agt          5093


<210>  4513
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  4513

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg 
            420                 425                 430


Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe 
        435                 440                 445


Ala 



<210>  4514
<211>  4164
<212>  DNA
<213>  Homo sapiens

<400>  4514
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   1980

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2040

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2100

atcaaacccg gagttcttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2160

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2220

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2280

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2340

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2400

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2460

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2520

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2580

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2640

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2700

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2760

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2820

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2880

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   2940

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3000

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca   3060

tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg   3120

atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag   3180

actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc   3240

ctaggcttaa agtatcagtg gttgagaaga gcttttcgga cctgttacta ccccaagctg   3300

tagccttgag ttacggtgtt tattttccaa tcaagtgaag atatctccta cttctcctac   3360

tggaacatct cagcttctgc agtgaagaaa aattcctgtg atagttcagt tctttagttt   3420

ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt tcacggctct ccttaatgac   3480

tgagtgaaca gttcctatct gtatatttga ctaaaccttt tcctaagcta tctctcatgg   3540

ttcctatgtt tttttatcat aattaaaagc aaaaccatct ggatcaccta acagtcagag   3600

gtcagtatct cagcgtgtga attatagagg aaatacagag agaacctctt ccacttttac   3660

ttttcgtcca aataaaatgc atggtgtacc agaagttgaa gatcgggttg aggattgggg   3720

ctagctcgat gacactaagg ccccaacatc gcgggacctg ctgtggcgcg gattcttagg   3780

aacgctgttc tagccggccc cctctccagg ggtcgccgtg gccggcatta tttcctagtt   3840

cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg gctaaggatg   3900

caacctctga cgttctgcgc cttcctagga gagtcttaca tgtgttgaga tttcacaagc   3960

aatgcgagtt gtaaaatacc agctctacaa gaagctaggc tctgtgacgg catagttttc   4020

agtagcttta tcacaatatt cacaatggag aattatatga catggtagca gaaataggcc   4080

cttttatgtg ttgcttctat tttacctcaa attgtagata tagggtaatc aataaaatcc   4140

atccatgcct ttcacacact aagt                                          4164


<210>  4515
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  4515

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
                565                 570                 575


Ser Ser Leu Leu Lys Asn Leu Asn 
            580


<210>  4516
<211>  7895
<212>  DNA
<213>  Homo sapiens

<400>  4516
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   1980

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2040

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2100

tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg tttggaattc   2160

cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg   2220

aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc   2280

agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca   2340

ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga   2400

ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga   2460

atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg   2520

aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg   2580

aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg   2640

gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa   2700

agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa   2760

aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca   2820

ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac   2880

agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg   2940

gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg   3000

atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga   3060

gaaggatctt agactctgcc gagtttatca aattcacggt cattaggtaa gtgagagttt   3120

cctgcttagt cacaggagcg aatctggagc tcatgaggct gactcttcta aaatgcagcc   3180

acaggtagtc atcgaatccg gcttcctatg ctgtgcaatc aacaaatcaa aataacttgt   3240

gtcatcatta gaatgtcaga tgtgcttcta cgaactaagc tgactctttt aattctttgg   3300

caaagggttg gcaaactagg actgtttgcc aaattcaggc tgcctcctat ttttagagtc   3360

ttcctgaaac acagctacac ccgtattatc catggctgct ttcctgtcac agtgagtaag   3420

tagctgggac tgagaaggca tggcctccaa agtctaaaat atttactctc tagcactttg   3480

tagaaaaacc ttagctaggc acagtggcta acgcctgtaa tcccagcatt ttgggaggcc   3540

aaggcaggca gatcacctga ggtcaggagt tccagaccag cctggccaac atggtgaaat   3600

cccatctcta caaaaataaa acagttagct gggcatgatg gcgggtgcct gtaatcccag   3660

ctactcggga ggctgaggca ggatagtcgc ttgaacccag gaggtggagg ttgcaatgag   3720

ccaagatcat gccactgcac tccagcctgg acgacagagt gagactccat cacaagaaaa   3780

aaagaacttt gtcaacctct gtcttagggc gccttgtcac aggcttcggg tcagacggat   3840

tcaaccttgc atcagccatt tgttagccag gtcactctgt tctttgtctg taaatgagat   3900

tgatcgttgt tcccactgag agtgtcagct ccttcccgta gagcaggcat gatgattgta   3960

ctcacctctg acaccattgt gagtgccaca ttccttccca cgtccttgtc actgtaagag   4020

atgcccacct gagcaccaac cccaggttat cttccccttt gtcttccagc cccccagaaa   4080

cagctacgac tcaacctacc caatcatttc atcatcagat tgccactgtc tctagttcag   4140

gtctcttggg actggcactc agaaatctca taataaatcc tcttgaggct tctcatacac   4200

tcgtcttctt ccaatcttct ttccctcaaa atctcatatt ttggttccac ttcacccacc   4260

gtcattctcc atatcactcc caggagttag gcaaaaagcc ccttccgttc ttccgtatgt   4320

taaacttaga atcactctgt tccctgctct gcgtttctat tttttgtttt tcctccattt   4380

actagtagct taacactttc taacagtgtt cttattattg atacgtatct atctcttcca   4440

taagcttata aggtcacgga taatacttct cattgtagta cgtaaatgac gtgggctaga   4500

tatgagttga ataaacagtt atacctgtaa attcttacag agtgaaaata aattgttata   4560

ctttacaatt tgtttctctc tttagaccat ttccaggact tgtgattaat aaccgtgagt   4620

attttgtgaa gtgttttgtt tttgtttttt cctggggtct gacgtgtgtg cgtgtgagtg   4680

tgtatacatg cttaacgtat atcacgttac ttcacctatg tcagtaacca ggccaaatac   4740

ttgttttagc cctcagtaaa aacaccaggc acttcctagt tgtaaaatta ttcaagcttc   4800

ttaacttcct atcctcgatg cacttaatca taaaatggta ataatagcac cgattttggg   4860

ggagtcgttc cagtagatgg aaagcatctg gaacaggtgt cagcaagctc ctgccgacgt   4920

gtatgcataa agttttattg aaaccaccat cgtgtccatt tgtttatggc agaactgaga   4980

gatggcagca gcaagtgtgt gcctgcaaaa cctaaaatat ttactaattg gctctgcaag   5040

aaaagagttt gcatccccct aacctagaac agtgtctagc ctctagtatg tgtttagcct   5100

acagtatgtg ctcagcgaat acaatctata tttattactg cttttatgac tgttataatt   5160

actgtgcttg gatttcgtta caaagtaagt cacaatgtgc ctgcttctgt tagtatttca   5220

gcacagtgcc tggcacacat ggggctctca aatattgctg agcgagtgaa caaatgtcct   5280

ttcaattcct taacgttgat gtcattttca atagtatttt gagccaaact taattttgcg   5340

agtgtgtttt gttttcttaa ctttattatt aaaaatgtat aaaagtgagg ccaggcgtgg   5400

tggctcacgc ctgtaatccc agcagtttgg gaggctgagg caggcggatc agttgaggtt   5460

gggagttgga gaccagcccg tccaacatgg tgaaagcctg tctctactaa aaatacaaaa   5520

atcagctggg tgtggtggcg cgtgcctgta atcccagcta ctcaggaggc tgaggcagga   5580

gagttgcttg aatcctagag gtggaggttg cagtgagctg agatcgtgcc attgcactcc   5640

agcctgggca acaagagcaa aactctgtcc caataaataa ataaataaaa tgttctcttt   5700

tgttcctgtt cttgtgcggt agtgtggtat agagttttat ggtaattact gtgaattagt   5760

gattctgagg gacatatcag aactctgagg tttgtttcct tctcatcttg agggaaacag   5820

caaatgtatg ttaaaatgct tttccaaggg aacaacacat ccttacatta tttaaaccaa   5880

tctgcttcat tttcagagct ggttgatcag agtgagtcag aaggccccgt gatacaagaa   5940

tcagctgaac caagccagtt ggaagttcca gccacagaag aaataaaaga gactgatgga   6000

agctctcaga tcaagcaaga accagacccc acgtggtaga cctcttccct cctagggtaa   6060

atcagcttct gtgtcaggga tgctgtgtgg tgtccatctg aaccccctgc atacgcgtag   6120

ctaatgtgat ctccccactt tcacataaga tggtggccct gccttcaggg aatgtgggag   6180

ccaggtggga gccttcccgg atatttaagc tagaagattc tacagggaga ttctccttgg   6240

atcaatatat gtctctcagt caaagatgta aaagcacttt tgccttaaaa agaatgttct   6300

gtttctaaat agagtcaacg ttgtcctcct cattggaatt cactatgagt cagaatcatt   6360

agactgactt ttttttttcc atagtaatag tattttgcag agtctcacag agctgcagat   6420

cttttgttca tcttgcagag ttaacaagtc tgatcctgtt agtccagatt tcttaaattt   6480

ggccaagtta taataggagc agtagcttga gacccgaagt caggaaactt tgacaatgga   6540

tttttttttt taatccagag acttgtactg gaatttgcct taccctgtca gctcatggac   6600

ttaaggtttc atcccgcttt atgagtgctt ctgaatccaa gtcattgtta cctgaatttg   6660

caaattaagt tgtgatattc gtgactgtta aattcctgta attagattaa cctctttgct   6720

tgcttgtttg ttttctctcc tattttagct taaagtatca gtggttgaga agagcttttc   6780

ggacctgtta ctaccccaag ctgtgtaata tacttgtata acagaaatac cttctataca   6840

aacctttttt tctactttta gatagaaatg tctacttttt cagcagttct gtgaattaaa   6900

gagcagagtg actgtgggtc tggaatggct ggtgtacttg ggaatgtact atcaggattt   6960

tacagcaatg ctgggaaatg acagggaaaa tgacaggaat gaatctcacc agatttttta   7020

tgtactcagc agagccttga gttacggtgt ttattttcca atcaagtgaa gatatctcct   7080

acttctccta ctggaacatc tcagcttctg cagtgaagaa aaattcctgt gatagttcag   7140

ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa tgatcctttg ttcacggctc   7200

tccttaatga ctgagtgaac agttcctatc tgtatatttg actaaacctt ttcctaagct   7260

atctctcatg gttcctatgt ttttttatca taattaaaag caaaaccatc tggatcacct   7320

aacagtcaga ggtcagtatc tcagcgtgtg aattatagag gaaatacaga gagaacctct   7380

tccactttta cttttcgtcc aaataaaatg catggtgtac cagaagttga agatcgggtt   7440

gaggattggg gctagctcga tgacactaag gccccaacat cgcgggacct gctgtggcgc   7500

ggattcttag gaacgctgtt ctagccggcc ccctctccag gggtcgccgt ggccggcatt   7560

atttcctagt tcttcttgta accctgaggt gccagcgcgg ggagtgagga ggggtcaggg   7620

ggctaaggat gcaacctctg acgttctgcg ccttcctagg agagtcttac atgtgttgag   7680

atttcacaag caatgcgagt tgtaaaatac cagctctaca agaagctagg ctctgtgacg   7740

gcatagtttt cagtagcttt atcacaatat tcacaatgga gaattatatg acatggtagc   7800

agaaataggc ccttttatgt gttgcttcta ttttacctca aattgtagat atagggtaat   7860

caataaaatc catccatgcc tttcacacac taagt                              7895


<210>  4517
<211>  902
<212>  PRT
<213>  Homo sapiens

<400>  4517

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile 
        515                 520                 525


Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
545                 550                 555                 560


Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile 
                565                 570                 575


Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile 
            580                 585                 590


Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu 
        595                 600                 605


Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys 
    610                 615                 620


Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys 
625                 630                 635                 640


Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro 
                645                 650                 655


Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val 
            660                 665                 670


Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala 
        675                 680                 685


Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys 
    690                 695                 700


Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala 
705                 710                 715                 720


Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu 
                725                 730                 735


Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu 
            740                 745                 750


Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro 
        755                 760                 765


Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro 
    770                 775                 780


Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly 
785                 790                 795                 800


Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn 
                805                 810                 815


Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val 
            820                 825                 830


Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe 
        835                 840                 845


Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val 
    850                 855                 860


Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr 
865                 870                 875                 880


Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile 
                885                 890                 895


Lys Phe Thr Val Ile Arg 
            900


<210>  4518
<211>  5211
<212>  DNA
<213>  Homo sapiens

<400>  4518
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   2040

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2100

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2160

atcaaacccg gagttcttgt atgtggaagg cttgccagag gggattccct tccgaagccc   2220

tacctggttt ggaattccac gacttgaaag gatcgtccgc gggagtaata aaatcaagtt   2280

cgttgttaaa aaacctgaac tagttatttc ctacttgcct cctgggatgg ctagtaaaat   2340

aaacactaaa gctttgcagt cccccaaaag accacgaagt cctgggagta attcaaaggt   2400

tcctgaaatt gaggtcaccg tggaaggccc taataacaac aatcctcaaa cctcagctgt   2460

tcgaaccccg acccagacta acggttctaa cgttcccttc aagccacgag ggagagagtt   2520

ttcctttgag gcctggaatg ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt   2580

caatgagaaa tgtggggaag ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt   2640

atttgagtct ttcccggaag acttttatgt ggaaggctta cctgagggtg tgccattccg   2700

aagaccatcg acttttggca ttccgaggct ggagaagata ctcagaaaca aagccaaaat   2760

taagttcatc attaaaaagc ccgaaatgtt tgagacggcg attaaggaga gcacctcctc   2820

taagagccct cccagaaaaa taaattcatc acccaatgtt aatactactg catcaggtgt   2880

tgaagacctt aacatcattc aggtgacaat tccagatgat gataatgaaa gactctcgaa   2940

agttgaaaaa gctagacagc taagagaaca agtgaatgac ctctttagtc ggaaatttgg   3000

tgaagctatt ggtatgggtt ttcctgtgaa agttccctac aggaaaatca caattaaccc   3060

tggctgtgtg gtggttgatg gcatgccccc gggggtgtcc ttcaaagccc ccagctacct   3120

ggaaatcagc tccatgagaa ggatcttaga ctctgccgag tttatcaaat tcacggtcat   3180

tagaccattt ccaggacttg tgattaataa ccagctggtt gatcagagtg agtcagaagg   3240

ccccgtgata caagaatcag ctgaaccaag ccagttggaa gttccagcca cagaagaaat   3300

aaaagagact gatggaagct ctcagatcaa gcaagaacca gaccccacgt ggtagacctc   3360

ttccctccta gggtaaatca gcttctgtgt cagggatgct gtgtggtgtc catctgaacc   3420

ccctgcatac gcgtagctaa tgtgatctcc ccactttcac ataagatggt ggccctgcct   3480

tcagggaatg tgggagccag gtgggagcct tcccggatat ttaagctaga agattctaca   3540

gggagattct ccttggatca atatatgtct ctcagtcaaa gatgtaaaag cacttttgcc   3600

ttaaaaagaa tgttctgttt ctaaatagag tcaacgttgt cctcctcatt ggaattcact   3660

atgagtcaga atcattagac tgactttttt ttttccatag taatagtatt ttgcagagtc   3720

tcacagagct gcagatcttt tgttcatctt gcagagttaa caagtctgat cctgttagtc   3780

cagatttctt aaatttggcc aagttataat aggagcagta gcttgagacc cgaagtcagg   3840

aaactttgac aatggatttt tttttttaat ccagagactt gtactggaat ttgccttacc   3900

ctgtcagctc atggacttaa ggtttcatcc cgctttatga gtgcttctga atccaagtca   3960

ttgttacctg aatttgcaaa ttaagttgtg atattcgtga ctgttaaatt cctgtaatta   4020

gattaacctc tttgcttgct tgtttgtttt ctctcctatt ttagcttaaa gtatcagtgg   4080

ttgagaagag cttttcggac ctgttactac cccaagctgt gtaatatact tgtataacag   4140

aaataccttc tatacaaacc tttttttcta cttttagata gaaatgtcta ctttttcagc   4200

agttctgtga attaaagagc agagtgactg tgggtctgga atggctggtg tacttgggaa   4260

tgtactatca ggattttaca gcaatgctgg gaaatgacag ggaaaatgac aggaatgaat   4320

ctcaccagat tttttatgta ctcagcagag ccttgagtta cggtgtttat tttccaatca   4380

agtgaagata tctcctactt ctcctactgg aacatctcag cttctgcagt gaagaaaaat   4440

tcctgtgata gttcagttct ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat   4500

cctttgttca cggctctcct taatgactga gtgaacagtt cctatctgta tatttgacta   4560

aaccttttcc taagctatct ctcatggttc ctatgttttt ttatcataat taaaagcaaa   4620

accatctgga tcacctaaca gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa   4680

tacagagaga acctcttcca cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga   4740

agttgaagat cgggttgagg attggggcta gctcgatgac actaaggccc caacatcgcg   4800

ggacctgctg tggcgcggat tcttaggaac gctgttctag ccggccccct ctccaggggt   4860

cgccgtggcc ggcattattt cctagttctt cttgtaaccc tgaggtgcca gcgcggggag   4920

tgaggagggg tcagggggct aaggatgcaa cctctgacgt tctgcgcctt cctaggagag   4980

tcttacatgt gttgagattt cacaagcaat gcgagttgta aaataccagc tctacaagaa   5040

gctaggctct gtgacggcat agttttcagt agctttatca caatattcac aatggagaat   5100

tatatgacat ggtagcagaa ataggccctt ttatgtgttg cttctatttt acctcaaatt   5160

gtagatatag ggtaatcaat aaaatccatc catgcctttc acacactaag t            5211


<210>  4519
<211>  977
<212>  PRT
<213>  Homo sapiens

<400>  4519

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
                565                 570                 575


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
            580                 585                 590


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
        595                 600                 605


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
    610                 615                 620


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
625                 630                 635                 640


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
                645                 650                 655


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
            660                 665                 670


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
        675                 680                 685


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
    690                 695                 700


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
705                 710                 715                 720


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
                725                 730                 735


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
            740                 745                 750


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
        755                 760                 765


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
    770                 775                 780


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
785                 790                 795                 800


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
                805                 810                 815


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
            820                 825                 830


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
        835                 840                 845


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
    850                 855                 860


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
865                 870                 875                 880


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
                885                 890                 895


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
            900                 905                 910


Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile 
        915                 920                 925


Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln 
    930                 935                 940


Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile 
945                 950                 955                 960


Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr 
                965                 970                 975


Trp 



<210>  4520
<211>  7203
<212>  DNA
<213>  Homo sapiens

<400>  4520
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   1980

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2040

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2100

tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg tttggaattc   2160

cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg   2220

aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc   2280

agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca   2340

ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga   2400

ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga   2460

atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg   2520

aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg   2580

aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg   2640

gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa   2700

agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa   2760

aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca   2820

ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac   2880

agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg   2940

gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg   3000

atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga   3060

gaaggatctt agactctgcc gagtttatca aattcacggt cattaggtaa gtgagagttt   3120

cctgcttagt cacaggagcg aatctggagc tcatgaggct gactcttcta aaatgcagcc   3180

acaggtagtc atcgaatccg gcttcctatg ctgtgcaatc aacaaatcaa aataacttgt   3240

gtcatcatta gaatgtcaga tgtgcttcta cgaactaagc tgactctttt aattctttgg   3300

caaagggttg gcaaactagg actgtttgcc aaattcaggc tgcctcctat ttttagagtc   3360

ttcctgaaac acagctacac ccgtattatc catggctgct ttcctgtcac agtgagtaag   3420

tagctgggac tgagaaggca tggcctccaa agtctaaaat atttactctc tagcactttg   3480

tagaaaaacc ttagctaggc acagtggcta acgcctgtaa tcccagcatt ttgggaggcc   3540

aaggcaggca gatcacctga ggtcaggagt tccagaccag cctggccaac atggtgaaat   3600

cccatctcta caaaaataaa acagttagct gggcatgatg gcgggtgcct gtaatcccag   3660

ctactcggga ggctgaggca ggatagtcgc ttgaacccag gaggtggagg ttgcaatgag   3720

ccaagatcat gccactgcac tccagcctgg acgacagagt gagactccat cacaagaaaa   3780

aaagaacttt gtcaacctct gtcttagggc gccttgtcac aggcttcggg tcagacggat   3840

tcaaccttgc atcagccatt tgttagccag gtcactctgt tctttgtctg taaatgagat   3900

tgatcgttgt tcccactgag agtgtcagct ccttcccgta gagcaggcat gatgattgta   3960

ctcacctctg acaccattgt gagtgccaca ttccttccca cgtccttgtc actgtaagag   4020

atgcccacct gagcaccaac cccaggttat cttccccttt gtcttccagc cccccagaaa   4080

cagctacgac tcaacctacc caatcatttc atcatcagat tgccactgtc tctagttcag   4140

gtctcttggg actggcactc agaaatctca taataaatcc tcttgaggct tctcatacac   4200

tcgtcttctt ccaatcttct ttccctcaaa atctcatatt ttggttccac ttcacccacc   4260

gtcattctcc atatcactcc caggagttag gcaaaaagcc ccttccgttc ttccgtatgt   4320

taaacttaga atcactctgt tccctgctct gcgtttctat tttttgtttt tcctccattt   4380

actagtagct taacactttc taacagtgtt cttattattg atacgtatct atctcttcca   4440

taagcttata aggtcacgga taatacttct cattgtagta cgtaaatgac gtgggctaga   4500

tatgagttga ataaacagtt atacctgtaa attcttacag agtgaaaata aattgttata   4560

ctttacaatt tgtttctctc tttagaccat ttccaggact tgtgattaat aaccgtgagt   4620

attttgtgaa gtgttttgtt tttgtttttt cctggggtct gacgtgtgtg cgtgtgagtg   4680

tgtatacatg cttaacgtat atcacgttac ttcacctatg tcagtaacca ggccaaatac   4740

ttgttttagc cctcagtaaa aacaccaggc acttcctagt tgtaaaatta ttcaagcttc   4800

ttaacttcct atcctcgatg cacttaatca taaaatggta ataatagcac cgattttggg   4860

ggagtcgttc cagtagatgg aaagcatctg gaacaggtgt cagcaagctc ctgccgacgt   4920

gtatgcataa agttttattg aaaccaccat cgtgtccatt tgtttatggc agaactgaga   4980

gatggcagca gcaagtgtgt gcctgcaaaa cctaaaatat ttactaattg gctctgcaag   5040

aaaagagttt gcatccccct aacctagaac agtgtctagc ctctagtatg tgtttagcct   5100

acagtatgtg ctcagcgaat acaatctata tttattactg cttttatgac tgttataatt   5160

actgtgcttg gatttcgtta caaagtaagt cacaatgtgc ctgcttctgt tagtatttca   5220

gcacagtgcc tggcacacat ggggctctca aatattgctg agcgagtgaa caaatgtcct   5280

ttcaattcct taacgttgat gtcattttca atagtatttt gagccaaact taattttgcg   5340

agtgtgtttt gttttcttaa ctttattatt aaaaatgtat aaaagtgagg ccaggcgtgg   5400

tggctcacgc ctgtaatccc agcagtttgg gaggctgagg caggcggatc agttgaggtt   5460

gggagttgga gaccagcccg tccaacatgg tgaaagcctg tctctactaa aaatacaaaa   5520

atcagctggg tgtggtggcg cgtgcctgta atcccagcta ctcaggaggc tgaggcagga   5580

gagttgcttg aatcctagag gtggaggttg cagtgagctg agatcgtgcc attgcactcc   5640

agcctgggca acaagagcaa aactctgtcc caataaataa ataaataaaa tgttctcttt   5700

tgttcctgtt cttgtgcggt agtgtggtat agagttttat ggtaattact gtgaattagt   5760

gattctgagg gacatatcag aactctgagg tttgtttcct tctcatcttg agggaaacag   5820

caaatgtatg ttaaaatgct tttccaaggg aacaacacat ccttacatta tttaaaccaa   5880

tctgcttcat tttcagagct ggttgatcag agtgagtcag aaggccccgt gatacaagaa   5940

tcagctgaac caagccagtt ggaagttcca gccacagaag aaataaaaga gactgatgga   6000

agctctcaga tcaagcaaga accagacccc acgtggtaga cctcttccct cctaggctta   6060

aagtatcagt ggttgagaag agcttttcgg acctgttact accccaagct gtgtaatata   6120

cttgtataac agaaatacct tctatacaaa cctttttttc tacttttaga tagaaatgtc   6180

tactttttca gcagttctgt gaattaaaga gcagagtgac tgtgggtctg gaatggctgg   6240

tgtacttggg aatgtactat caggatttta cagcaatgct gggaaatgac agggaaaatg   6300

acaggaatga atctcaccag attttttatg tactcagcag agccttgagt tacggtgttt   6360

attttccaat caagtgaaga tatctcctac ttctcctact ggaacatctc agcttctgca   6420

gtgaagaaaa attcctgtga tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat   6480

catttaaatg atcctttgtt cacggctctc cttaatgact gagtgaacag ttcctatctg   6540

tatatttgac taaacctttt cctaagctat ctctcatggt tcctatgttt ttttatcata   6600

attaaaagca aaaccatctg gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa   6660

ttatagagga aatacagaga gaacctcttc cacttttact tttcgtccaa ataaaatgca   6720

tggtgtacca gaagttgaag atcgggttga ggattggggc tagctcgatg acactaaggc   6780

cccaacatcg cgggacctgc tgtggcgcgg attcttagga acgctgttct agccggcccc   6840

ctctccaggg gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac cctgaggtgc   6900

cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc   6960

ttcctaggag agtcttacat gtgttgagat ttcacaagca atgcgagttg taaaatacca   7020

gctctacaag aagctaggct ctgtgacggc atagttttca gtagctttat cacaatattc   7080

acaatggaga attatatgac atggtagcag aaataggccc ttttatgtgt tgcttctatt   7140

ttacctcaaa ttgtagatat agggtaatca ataaaatcca tccatgcctt tcacacacta   7200

agt                                                                 7203


<210>  4521
<211>  902
<212>  PRT
<213>  Homo sapiens

<400>  4521

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile 
        515                 520                 525


Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
545                 550                 555                 560


Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile 
                565                 570                 575


Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile 
            580                 585                 590


Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu 
        595                 600                 605


Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys 
    610                 615                 620


Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys 
625                 630                 635                 640


Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro 
                645                 650                 655


Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val 
            660                 665                 670


Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala 
        675                 680                 685


Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys 
    690                 695                 700


Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala 
705                 710                 715                 720


Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu 
                725                 730                 735


Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu 
            740                 745                 750


Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro 
        755                 760                 765


Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro 
    770                 775                 780


Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly 
785                 790                 795                 800


Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn 
                805                 810                 815


Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val 
            820                 825                 830


Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe 
        835                 840                 845


Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val 
    850                 855                 860


Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr 
865                 870                 875                 880


Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile 
                885                 890                 895


Lys Phe Thr Val Ile Arg 
            900


<210>  4522
<211>  3823
<212>  DNA
<213>  Homo sapiens

<400>  4522
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   1980

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2040

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2100

tgaaaggatc gtccgcggga gtaataaaat caagttcgtt gttaaaaaac ctgaactagt   2160

tatttcctac ttgcctcctg ggatggctag taaaataaac actaaagctt tgcagtcccc   2220

caaaagacca cgaagtcctg ggagtaattc aaaggttcct gaaattgagg tcaccgtgga   2280

aggccctaat aacaacaatc ctcaaacctc agctgttcga accccgaccc agactaacgg   2340

ttctaacgtt cccttcaagc cacgagggag agagttttcc tttgaggcct ggaatgccaa   2400

aatcacggac ctaaaacaga aagttgaaaa tctcttcaat gagaaatgtg gggaagctct   2460

tggccttaaa caagctgtga aggtgccgtt cgcgttattt gagtctttcc cggaagactt   2520

ttatgtggaa ggcttacctg agggtgtgcc attccgaaga ccatcgactt ttggcattcc   2580

gaggctggag aagatactca gaaacaaagc caaaattaag ttcatcatta aaaagcccga   2640

aatgtttgag acggcgatta aggagagcac ctcctctaag agccctccca gaaaaataaa   2700

ttcatcaccc aatgttaata ctactgcatc aggtgttgaa gaccttaaca tcattcaggt   2760

gacaattcca gatgatgata atgaaagact ctcgaaagtt gaaaaagcta gacagctaag   2820

agaacaagtg aatgacctct ttagtcggaa atttggtgaa gctattggta tgggttttcc   2880

tgtgaaagtt ccctacagga aaatcacaat taaccctggc tgtgtggtgg ttgatggcat   2940

gcccccgggg gtgtccttca aagcccccag ctacctggaa atcagctcca tgagaaggat   3000

cttagactct gccgagttta tcaaattcac ggtcattaga ccatttccag gacttgtgat   3060

taataaccag ctggttgatc agagtgagtc agaaggcccc gtgatacaag aatcagctga   3120

accaagccag ttggaagttc cagccacaga agaaataaaa gagactgatg gaagctctca   3180

gatcaagcaa gaaccagacc ccacgtggta gacctcttcc ctcctaggca aaaccatctg   3240

gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa ttatagagga aatacagaga   3300

gaacctcttc cacttttact tttcgtccaa ataaaatgca tggtgtacca gaagttgaag   3360

atcgggttga ggattggggc tagctcgatg acactaaggc cccaacatcg cgggacctgc   3420

tgtggcgcgg attcttagga acgctgttct agccggcccc ctctccaggg gtcgccgtgg   3480

ccggcattat ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg   3540

ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc ttcctaggag agtcttacat   3600

gtgttgagat ttcacaagca atgcgagttg taaaatacca gctctacaag aagctaggct   3660

ctgtgacggc atagttttca gtagctttat cacaatattc acaatggaga attatatgac   3720

atggtagcag aaataggccc ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat   3780

agggtaatca ataaaatcca tccatgcctt tcacacacta agt                     3823


<210>  4523
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  4523

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile 
        515                 520                 525


Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
545                 550                 555                 560


Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys 
                565                 570                 575


Ser Ser Ser Leu Leu Lys Asn Leu Asn 
            580                 585


<210>  4524
<211>  7148
<212>  DNA
<213>  Homo sapiens

<400>  4524
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagctca   1980

agctcttgga ctcaccgagg cagtaaaagt accatatcct gtgtttgaat caaacccgga   2040

gttcttgtat gtggaaggct tgccagaggg gattcccttc cgaagcccta cctggtttgg   2100

aattccacga cttgaaagga tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa   2160

acctgaacta gttatttcct acttgcctcc tgggatggct agtaaaataa acactaaagc   2220

tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga   2280

ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc tcagctgttc gaaccccgac   2340

ccagactaac ggttctaacg ttcccttcaa gccacgaggg agagagtttt cctttgaggc   2400

ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa aatctcttca atgagaaatg   2460

tggggaagct cttggcctta aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt   2520

cccggaagac ttttatgtgg aaggcttacc tgagggtgtg ccattccgaa gaccatcgac   2580

ttttggcatt ccgaggctgg agaagatact cagaaacaaa gccaaaatta agttcatcat   2640

taaaaagccc gaaatgtttg agacggcgat taaggagagc acctcctcta agagccctcc   2700

cagaaaaata aattcatcac ccaatgttaa tactactgca tcaggtgttg aagaccttaa   2760

catcattcag gtgacaattc cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc   2820

tagacagcta agagaacaag tgaatgacct ctttagtcgg aaatttggtg aagctattgg   2880

tatgggtttt cctgtgaaag ttccctacag gaaaatcaca attaaccctg gctgtgtggt   2940

ggttgatggc atgcccccgg gggtgtcctt caaagccccc agctacctgg aaatcagctc   3000

catgagaagg atcttagact ctgccgagtt tatcaaattc acggtcatta ggtaagtgag   3060

agtttcctgc ttagtcacag gagcgaatct ggagctcatg aggctgactc ttctaaaatg   3120

cagccacagg tagtcatcga atccggcttc ctatgctgtg caatcaacaa atcaaaataa   3180

cttgtgtcat cattagaatg tcagatgtgc ttctacgaac taagctgact cttttaattc   3240

tttggcaaag ggttggcaaa ctaggactgt ttgccaaatt caggctgcct cctattttta   3300

gagtcttcct gaaacacagc tacacccgta ttatccatgg ctgctttcct gtcacagtga   3360

gtaagtagct gggactgaga aggcatggcc tccaaagtct aaaatattta ctctctagca   3420

ctttgtagaa aaaccttagc taggcacagt ggctaacgcc tgtaatccca gcattttggg   3480

aggccaaggc aggcagatca cctgaggtca ggagttccag accagcctgg ccaacatggt   3540

gaaatcccat ctctacaaaa ataaaacagt tagctgggca tgatggcggg tgcctgtaat   3600

cccagctact cgggaggctg aggcaggata gtcgcttgaa cccaggaggt ggaggttgca   3660

atgagccaag atcatgccac tgcactccag cctggacgac agagtgagac tccatcacaa   3720

gaaaaaaaga actttgtcaa cctctgtctt agggcgcctt gtcacaggct tcgggtcaga   3780

cggattcaac cttgcatcag ccatttgtta gccaggtcac tctgttcttt gtctgtaaat   3840

gagattgatc gttgttccca ctgagagtgt cagctccttc ccgtagagca ggcatgatga   3900

ttgtactcac ctctgacacc attgtgagtg ccacattcct tcccacgtcc ttgtcactgt   3960

aagagatgcc cacctgagca ccaaccccag gttatcttcc cctttgtctt ccagcccccc   4020

agaaacagct acgactcaac ctacccaatc atttcatcat cagattgcca ctgtctctag   4080

ttcaggtctc ttgggactgg cactcagaaa tctcataata aatcctcttg aggcttctca   4140

tacactcgtc ttcttccaat cttctttccc tcaaaatctc atattttggt tccacttcac   4200

ccaccgtcat tctccatatc actcccagga gttaggcaaa aagccccttc cgttcttccg   4260

tatgttaaac ttagaatcac tctgttccct gctctgcgtt tctatttttt gtttttcctc   4320

catttactag tagcttaaca ctttctaaca gtgttcttat tattgatacg tatctatctc   4380

ttccataagc ttataaggtc acggataata cttctcattg tagtacgtaa atgacgtggg   4440

ctagatatga gttgaataaa cagttatacc tgtaaattct tacagagtga aaataaattg   4500

ttatacttta caatttgttt ctctctttag accatttcca ggacttgtga ttaataaccg   4560

tgagtatttt gtgaagtgtt ttgtttttgt tttttcctgg ggtctgacgt gtgtgcgtgt   4620

gagtgtgtat acatgcttaa cgtatatcac gttacttcac ctatgtcagt aaccaggcca   4680

aatacttgtt ttagccctca gtaaaaacac caggcacttc ctagttgtaa aattattcaa   4740

gcttcttaac ttcctatcct cgatgcactt aatcataaaa tggtaataat agcaccgatt   4800

ttgggggagt cgttccagta gatggaaagc atctggaaca ggtgtcagca agctcctgcc   4860

gacgtgtatg cataaagttt tattgaaacc accatcgtgt ccatttgttt atggcagaac   4920

tgagagatgg cagcagcaag tgtgtgcctg caaaacctaa aatatttact aattggctct   4980

gcaagaaaag agtttgcatc cccctaacct agaacagtgt ctagcctcta gtatgtgttt   5040

agcctacagt atgtgctcag cgaatacaat ctatatttat tactgctttt atgactgtta   5100

taattactgt gcttggattt cgttacaaag taagtcacaa tgtgcctgct tctgttagta   5160

tttcagcaca gtgcctggca cacatggggc tctcaaatat tgctgagcga gtgaacaaat   5220

gtcctttcaa ttccttaacg ttgatgtcat tttcaatagt attttgagcc aaacttaatt   5280

ttgcgagtgt gttttgtttt cttaacttta ttattaaaaa tgtataaaag tgaggccagg   5340

cgtggtggct cacgcctgta atcccagcag tttgggaggc tgaggcaggc ggatcagttg   5400

aggttgggag ttggagacca gcccgtccaa catggtgaaa gcctgtctct actaaaaata   5460

caaaaatcag ctgggtgtgg tggcgcgtgc ctgtaatccc agctactcag gaggctgagg   5520

caggagagtt gcttgaatcc tagaggtgga ggttgcagtg agctgagatc gtgccattgc   5580

actccagcct gggcaacaag agcaaaactc tgtcccaata aataaataaa taaaatgttc   5640

tcttttgttc ctgttcttgt gcggtagtgt ggtatagagt tttatggtaa ttactgtgaa   5700

ttagtgattc tgagggacat atcagaactc tgaggtttgt ttccttctca tcttgaggga   5760

aacagcaaat gtatgttaaa atgcttttcc aagggaacaa cacatcctta cattatttaa   5820

accaatctgc ttcattttca gagctggttg atcagagtga gtcagaaggc cccgtgatac   5880

aagaatcagc tgaaccaagc cagttggaag ttccagccac agaagaaata aaagagactg   5940

atggaagctc tcagatcaag caagaaccag accccacgtg gtagacctct tccctcctag   6000

gcttaaagta tcagtggttg agaagagctt ttcggacctg ttactacccc aagctgtgta   6060

atatacttgt ataacagaaa taccttctat acaaaccttt ttttctactt ttagatagaa   6120

atgtctactt tttcagcagt tctgtgaatt aaagagcaga gtgactgtgg gtctggaatg   6180

gctggtgtac ttgggaatgt actatcagga ttttacagca atgctgggaa atgacaggga   6240

aaatgacagg aatgaatctc accagatttt ttatgtactc agcagagcct tgagttacgg   6300

tgtttatttt ccaatcaagt gaagatatct cctacttctc ctactggaac atctcagctt   6360

ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa   6420

aaaatcattt aaatgatcct ttgttcacgg ctctccttaa tgactgagtg aacagttcct   6480

atctgtatat ttgactaaac cttttcctaa gctatctctc atggttccta tgttttttta   6540

tcataattaa aagcaaaacc atctggatca cctaacagtc agaggtcagt atctcagcgt   6600

gtgaattata gaggaaatac agagagaacc tcttccactt ttacttttcg tccaaataaa   6660

atgcatggtg taccagaagt tgaagatcgg gttgaggatt ggggctagct cgatgacact   6720

aaggccccaa catcgcggga cctgctgtgg cgcggattct taggaacgct gttctagccg   6780

gccccctctc caggggtcgc cgtggccggc attatttcct agttcttctt gtaaccctga   6840

ggtgccagcg cggggagtga ggaggggtca gggggctaag gatgcaacct ctgacgttct   6900

gcgccttcct aggagagtct tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa   6960

taccagctct acaagaagct aggctctgtg acggcatagt tttcagtagc tttatcacaa   7020

tattcacaat ggagaattat atgacatggt agcagaaata ggccctttta tgtgttgctt   7080

ctattttacc tcaaattgta gatatagggt aatcaataaa atccatccat gcctttcaca   7140

cactaagt                                                            7148


<210>  4525
<211>  877
<212>  PRT
<213>  Homo sapiens

<400>  4525

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
        515                 520                 525


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
    530                 535                 540


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
545                 550                 555                 560


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
                565                 570                 575


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
            580                 585                 590


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
        595                 600                 605


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
    610                 615                 620


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
625                 630                 635                 640


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
                645                 650                 655


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
            660                 665                 670


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
        675                 680                 685


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
    690                 695                 700


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
705                 710                 715                 720


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
                725                 730                 735


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
            740                 745                 750


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
        755                 760                 765


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
    770                 775                 780


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
785                 790                 795                 800


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
                805                 810                 815


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
            820                 825                 830


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
        835                 840                 845


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
    850                 855                 860


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
865                 870                 875


<210>  4526
<211>  3984
<212>  DNA
<213>  Homo sapiens

<400>  4526
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagctc   1860

aagctcttgg actcaccgag gcagtaaaag taccatatcc tgtgtttgaa tcaaacccgg   1920

agttcttgta tgtggaaggc ttgccagagg ggattccctt ccgaagccct acctggtttg   1980

gaattccacg acttgaaagg atcgtccgcg ggagtaataa aatcaagttc gttgttaaaa   2040

aacctgaact agttatttcc tacttgcctc ctgggatggc tagtaaaata aacactaaag   2100

ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa ttcaaaggtt cctgaaattg   2160

aggtcaccgt ggaaggccct aataacaaca atcctcaaac ctcagctgtt cgaaccccga   2220

cccagactaa cggttctaac gttcccttca agccacgagg gagagagttt tcctttgagg   2280

cctggaatgc caaaatcacg gacctaaaac agaaagttga aaatctcttc aatgagaaat   2340

gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc gttcgcgtta tttgagtctt   2400

tcccggaaga cttttatgtg gaaggcttac ctgagggtgt gccattccga agaccatcga   2460

cttttggcat tccgaggctg gagaagatac tcagaaacaa agccaaaatt aagttcatca   2520

ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag cacctcctct aagagccctc   2580

ccagaaaaat aaattcatca cccaatgtta atactactgc atcaggtgtt gaagacctta   2640

acatcattca ggtgacaatt ccagatgatg ataatgaaag actctcgaaa gttgaaaaag   2700

ctagacagct aagagaacaa gtgaatgacc tctttagtcg gaaatttggt gaagctattg   2760

gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac aattaaccct ggctgtgtgg   2820

tggttgatgg catgcccccg ggggtgtcct tcaaagcccc cagctacctg gaaatcagct   2880

ccatgagaag gatcttagac tctgccgagt ttatcaaatt cacggtcatt agaccatttc   2940

caggacttgt gattaataac cagctggttg atcagagtga gtcagaaggc cccgtgatac   3000

aagaatcagc tgaaccaagc cagttggaag ttccagccac agaagaaata aaagagactg   3060

atggaagctc tcagatcaag caagaaccag accccacgtg gtagacctct tccctcctag   3120

gagccttgag ttacggtgtt tattttccaa tcaagtgaag atatctccta cttctcctac   3180

tggaacatct cagcttctgc agtgaagaaa aattcctgtg atagttcagt tctttagttt   3240

ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt tcacggctct ccttaatgac   3300

tgagtgaaca gttcctatct gtatatttga ctaaaccttt tcctaagcta tctctcatgg   3360

ttcctatgtt tttttatcat aattaaaagc aaaaccatct ggatcaccta acagtcagag   3420

gtcagtatct cagcgtgtga attatagagg aaatacagag agaacctctt ccacttttac   3480

ttttcgtcca aataaaatgc atggtgtacc agaagttgaa gatcgggttg aggattgggg   3540

ctagctcgat gacactaagg ccccaacatc gcgggacctg ctgtggcgcg gattcttagg   3600

aacgctgttc tagccggccc cctctccagg ggtcgccgtg gccggcatta tttcctagtt   3660

cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg gctaaggatg   3720

caacctctga cgttctgcgc cttcctagga gagtcttaca tgtgttgaga tttcacaagc   3780

aatgcgagtt gtaaaatacc agctctacaa gaagctaggc tctgtgacgg catagttttc   3840

agtagcttta tcacaatatt cacaatggag aattatatga catggtagca gaaataggcc   3900

cttttatgtg ttgcttctat tttacctcaa attgtagata tagggtaatc aataaaatcc   3960

atccatgcct ttcacacact aagt                                          3984


<210>  4527
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  4527

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu 
            420                 425                 430


Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu 
        435                 440                 445


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp 
    450                 455                 460


Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile 
465                 470                 475                 480


Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro 
                485                 490                 495


Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg 
            500                 505                 510


Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr 
        515                 520                 525


Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr 
    530                 535                 540


Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg 
545                 550                 555                 560


Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln 
                565                 570                 575


Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu 
            580                 585                 590


Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu 
        595                 600                 605


Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro 
    610                 615                 620


Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala 
625                 630                 635                 640


Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile 
                645                 650                 655


Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser 
            660                 665                 670


Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile 
        675                 680                 685


Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu 
    690                 695                 700


Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys 
705                 710                 715                 720


Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg 
                725                 730                 735


Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro 
            740                 745                 750


Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg 
        755                 760                 765


Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro 
    770                 775                 780


Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser 
785                 790                 795                 800


Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val 
                805                 810                 815


Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys 
            820                 825                 830


Gln Glu Pro Asp Pro Thr Trp 
        835


<210>  4528
<211>  4631
<212>  DNA
<213>  Homo sapiens

<400>  4528
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   2040

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2100

gaaatttgct tagatttgtt gacagcggtt tcctggagtg ctgtcttgag aacgattctg   2160

aggaggctca gcaagaaaga gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa   2220

ctcaagctct tggactcacc gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc   2280

cggagttctt gtatgtggaa ggcttgccag aggggattcc cttccgaagc cctacctggt   2340

ttggaattcc acgacttgaa aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta   2400

aaaaacctga actagttatt tcctacttgc ctcctgggat ggctagtaaa ataaacacta   2460

aagctttgca gtcccccaaa agaccacgaa gtcctgggag taattcaaag gttcctgaaa   2520

ttgaggtcac cgtggaaggc cctaataaca acaatcctca aacctcagct gttcgaaccc   2580

cgacccagac taacggttct aacgttccct tcaagccacg agggagagag ttttcctttg   2640

aggcctggaa tgccaaaatc acggacctaa aacagaaagt tgaaaatctc ttcaatgaga   2700

aatgtgggga agctcttggc cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt   2760

ctttcccgga agacttttat gtggaaggct tacctgaggg tgtgccattc cgaagaccat   2820

cgacttttgg cattccgagg ctggagaaga tactcagaaa caaagccaaa attaagttca   2880

tcattaaaaa gcccgaaatg tttgagacgg cgattaagga gagcacctcc tctaagagcc   2940

ctcccagaaa aataaattca tcacccaatg ttaatactac tgcatcaggt gttgaagacc   3000

ttaacatcat tcaggtgaca attccagatg atgataatga aagactctcg aaagttgaaa   3060

aagctagaca gctaagagaa caagtgaatg acctctttag tcggaaattt ggtgaagcta   3120

ttggtatggg ttttcctgtg aaagttccct acaggaaaat cacaattaac cctggctgtg   3180

tggtggttga tggcatgccc ccgggggtgt ccttcaaagc ccccagctac ctggaaatca   3240

gctccatgag aaggatctta gactctgccg agtttatcaa attcacggtc attagaccat   3300

ttccaggact tgtgattaat aaccagctgg ttgatcagag tgagtcagaa ggccccgtga   3360

tacaagaatc agctgaacca agccagttgg aagttccagc cacagaagaa ataaaagaga   3420

ctgatggaag ctctcagatc aagcaagaac cagaccccac gtggtagacc tcttccctcc   3480

taggcttaaa gtatcagtgg ttgagaagag cttttcggac ctgttactac cccaagctgt   3540

gtaatatact tgtataacag aaataccttc tatacaaacc tttttttcta cttttagata   3600

gaaatgtcta ctttttcagc agttctgtga attaaagagc agagtgactg tgggtctgga   3660

atggctggtg tacttgggaa tgtactatca ggattttaca gcaatgctgg gaaatgacag   3720

ggaaaatgac aggaatgaat ctcaccagat tttttatgta ctcagcagag ccttgagtta   3780

cggtgtttat tttccaatca agtgaagata tctcctactt ctcctactgg aacatctcag   3840

cttctgcagt gaagaaaaat tcctgtgata gttcagttct ttagtttttc tatttgaaaa   3900

aaaaaaatca tttaaatgat cctttgttca cggctctcct taatgactga gtgaacagtt   3960

cctatctgta tatttgacta aaccttttcc taagctatct ctcatggttc ctatgttttt   4020

ttatcataat taaaagcaaa accatctgga tcacctaaca gtcagaggtc agtatctcag   4080

cgtgtgaatt atagaggaaa tacagagaga acctcttcca cttttacttt tcgtccaaat   4140

aaaatgcatg gtgtaccaga agttgaagat cgggttgagg attggggcta gctcgatgac   4200

actaaggccc caacatcgcg ggacctgctg tggcgcggat tcttaggaac gctgttctag   4260

ccggccccct ctccaggggt cgccgtggcc ggcattattt cctagttctt cttgtaaccc   4320

tgaggtgcca gcgcggggag tgaggagggg tcagggggct aaggatgcaa cctctgacgt   4380

tctgcgcctt cctaggagag tcttacatgt gttgagattt cacaagcaat gcgagttgta   4440

aaataccagc tctacaagaa gctaggctct gtgacggcat agttttcagt agctttatca   4500

caatattcac aatggagaat tatatgacat ggtagcagaa ataggccctt ttatgtgttg   4560

cttctatttt acctcaaatt gtagatatag ggtaatcaat aaaatccatc catgcctttc   4620

acacactaag t                                                        4631


<210>  4529
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  4529

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala 



<210>  4530
<211>  4004
<212>  DNA
<213>  Homo sapiens

<400>  4530
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1980

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   2040

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2100

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2160

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2220

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2280

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2340

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2400

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2460

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2520

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2580

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2640

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2700

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2760

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2820

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2880

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   2940

cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg atcagagtga   3000

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   3060

agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag accccacgtg   3120

gtagacctct tccctcctag gagccttgag ttacggtgtt tattttccaa tcaagtgaag   3180

atatctccta cttctcctac tggaacatct cagcttctgc agtgaagaaa aattcctgtg   3240

atagttcagt tctttagttt ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt   3300

tcacggctct ccttaatgac tgagtgaaca gttcctatct gtatatttga ctaaaccttt   3360

tcctaagcta tctctcatgg ttcctatgtt tttttatcat aattaaaagc aaaaccatct   3420

ggatcaccta acagtcagag gtcagtatct cagcgtgtga attatagagg aaatacagag   3480

agaacctctt ccacttttac ttttcgtcca aataaaatgc atggtgtacc agaagttgaa   3540

gatcgggttg aggattgggg ctagctcgat gacactaagg ccccaacatc gcgggacctg   3600

ctgtggcgcg gattcttagg aacgctgttc tagccggccc cctctccagg ggtcgccgtg   3660

gccggcatta tttcctagtt cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag   3720

gggtcagggg gctaaggatg caacctctga cgttctgcgc cttcctagga gagtcttaca   3780

tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc agctctacaa gaagctaggc   3840

tctgtgacgg catagttttc agtagcttta tcacaatatt cacaatggag aattatatga   3900

catggtagca gaaataggcc cttttatgtg ttgcttctat tttacctcaa attgtagata   3960

tagggtaatc aataaaatcc atccatgcct ttcacacact aagt                    4004


<210>  4531
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  4531

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
            420                 425                 430


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
        435                 440                 445


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
    450                 455                 460


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser 
465                 470                 475                 480


Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
                485                 490                 495


<210>  4532
<211>  5071
<212>  DNA
<213>  Homo sapiens

<400>  4532
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagc tcaagctctt ggactcaccg   2040

aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag   2100

gcttgccaga ggggattccc ttccgaagcc ctacctggtt tggaattcca cgacttgaaa   2160

ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt   2220

cctacttgcc tcctgggatg gctagtaaaa taaacactaa agctttgcag tcccccaaaa   2280

gaccacgaag tcctgggagt aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc   2340

ctaataacaa caatcctcaa acctcagctg ttcgaacccc gacccagact aacggttcta   2400

acgttccctt caagccacga gggagagagt tttcctttga ggcctggaat gccaaaatca   2460

cggacctaaa acagaaagtt gaaaatctct tcaatgagaa atgtggggaa gctcttggcc   2520

ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc tttcccggaa gacttttatg   2580

tggaaggctt acctgagggt gtgccattcc gaagaccatc gacttttggc attccgaggc   2640

tggagaagat actcagaaac aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt   2700

ttgagacggc gattaaggag agcacctcct ctaagagccc tcccagaaaa ataaattcat   2760

cacccaatgt taatactact gcatcaggtg ttgaagacct taacatcatt caggtgacaa   2820

ttccagatga tgataatgaa agactctcga aagttgaaaa agctagacag ctaagagaac   2880

aagtgaatga cctctttagt cggaaatttg gtgaagctat tggtatgggt tttcctgtga   2940

aagttcccta caggaaaatc acaattaacc ctggctgtgt ggtggttgat ggcatgcccc   3000

cgggggtgtc cttcaaagcc cccagctacc tggaaatcag ctccatgaga aggatcttag   3060

actctgccga gtttatcaaa ttcacggtca ttagaccatt tccaggactt gtgattaata   3120

accagctggt tgatcagagt gagtcagaag gccccgtgat acaagaatca gctgaaccaa   3180

gccagttgga agttccagcc acagaaggta aaaggacctc ttccctccta gggtaaatca   3240

gcttctgtgt cagggatgct gtgtggtgtc catctgaacc ccctgcatac gcgtagctaa   3300

tgtgatctcc ccactttcac ataagatggt ggccctgcct tcagggaatg tgggagccag   3360

gtgggagcct tcccggatat ttaagctaga agattctaca gggagattct ccttggatca   3420

atatatgtct ctcagtcaaa gatgtaaaag cacttttgcc ttaaaaagaa tgttctgttt   3480

ctaaatagag tcaacgttgt cctcctcatt ggaattcact atgagtcaga atcattagac   3540

tgactttttt ttttccatag taatagtatt ttgcagagtc tcacagagct gcagatcttt   3600

tgttcatctt gcagagttaa caagtctgat cctgttagtc cagatttctt aaatttggcc   3660

aagttataat aggagcagta gcttgagacc cgaagtcagg aaactttgac aatggatttt   3720

tttttttaat ccagagactt gtactggaat ttgccttacc ctgtcagctc atggacttaa   3780

ggtttcatcc cgctttatga gtgcttctga atccaagtca ttgttacctg aatttgcaaa   3840

ttaagttgtg atattcgtga ctgttaaatt cctgtaatta gattaacctc tttgcttgct   3900

tgtttgtttt ctctcctatt ttagcttaaa gtatcagtgg ttgagaagag cttttcggac   3960

ctgttactac cccaagctgt gtaatatact tgtataacag aaataccttc tatacaaacc   4020

tttttttcta cttttagata gaaatgtcta ctttttcagc agttctgtga attaaagagc   4080

agagtgactg tgggtctgga atggctggtg tacttgggaa tgtactatca ggattttaca   4140

gcaatgctgg gaaatgacag ggaaaatgac aggaatgaat ctcaccagat tttttatgta   4200

ctcagcagag ccttgagtta cggtgtttat tttccaatca agtgaagata tctcctactt   4260

ctcctactgg aacatctcag cttctgcagt gaagaaaaat tcctgtgata gttcagttct   4320

ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat cctttgttca cggctctcct   4380

taatgactga gtgaacagtt cctatctgta tatttgacta aaccttttcc taagctatct   4440

ctcatggttc ctatgttttt ttatcataat taaaagcaaa accatctgga tcacctaaca   4500

gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa tacagagaga acctcttcca   4560

cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga agttgaagat cgggttgagg   4620

attggggcta gctcgatgac actaaggccc caacatcgcg ggacctgctg tggcgcggat   4680

tcttaggaac gctgttctag ccggccccct ctccaggggt cgccgtggcc ggcattattt   4740

cctagttctt cttgtaaccc tgaggtgcca gcgcggggag tgaggagggg tcagggggct   4800

aaggatgcaa cctctgacgt tctgcgcctt cctaggagag tcttacatgt gttgagattt   4860

cacaagcaat gcgagttgta aaataccagc tctacaagaa gctaggctct gtgacggcat   4920

agttttcagt agctttatca caatattcac aatggagaat tatatgacat ggtagcagaa   4980

ataggccctt ttatgtgttg cttctatttt acctcaaatt gtagatatag ggtaatcaat   5040

aaaatccatc catgcctttc acacactaag t                                  5071


<210>  4533
<211>  944
<212>  PRT
<213>  Homo sapiens

<400>  4533

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly 
    530                 535                 540


Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro 
545                 550                 555                 560


Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser 
                565                 570                 575


Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser 
            580                 585                 590


Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr 
        595                 600                 605


Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser 
    610                 615                 620


Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile 
625                 630                 635                 640


Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala 
                645                 650                 655


Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro 
            660                 665                 670


Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp 
        675                 680                 685


Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala 
    690                 695                 700


Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser 
705                 710                 715                 720


Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe 
                725                 730                 735


Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg 
            740                 745                 750


Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu 
        755                 760                 765


Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile 
    770                 775                 780


Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu 
785                 790                 795                 800


Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser 
                805                 810                 815


Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe 
            820                 825                 830


Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val 
        835                 840                 845


Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly 
    850                 855                 860


Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser 
865                 870                 875                 880


Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val 
                885                 890                 895


Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln 
            900                 905                 910


Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln 
        915                 920                 925


Leu Glu Val Pro Ala Thr Glu Gly Lys Arg Thr Ser Ser Leu Leu Gly 
    930                 935                 940


<210>  4534
<211>  4530
<212>  DNA
<213>  Homo sapiens

<400>  4534
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   2040

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2100

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2160

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2220

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2280

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2340

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2400

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2460

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2520

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2580

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2640

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2700

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2760

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2820

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2880

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   2940

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   3000

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3060

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3120

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3180

ttcacggtca ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt   3240

gagtcagaag gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc   3300

acagaagaaa taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg   3360

tggtagacct cttccctcct aggcttaaag tatcagtggt tgagaagagc ttttcggacc   3420

tgttactacc ccaagctgtg taatatactt gtataacaga aataccttct atacaaacct   3480

ttttttctac ttttagatag aaatgtctac tttttcagca gttctgtgaa ttaaagagca   3540

gagtgactgt gggtctggaa tggctggtgt acttgggaat gtactatcag gattttacag   3600

caatgctggg aaatgacagg gaaaatgaca ggaatgaatc tcaccagatt ttttatgtac   3660

tcagcagagc cttgagttac ggtgtttatt ttccaatcaa gtgaagatat ctcctacttc   3720

tcctactgga acatctcagc ttctgcagtg aagaaaaatt cctgtgatag ttcagttctt   3780

tagtttttct atttgaaaaa aaaaaatcat ttaaatgatc ctttgttcac ggctctcctt   3840

aatgactgag tgaacagttc ctatctgtat atttgactaa accttttcct aagctatctc   3900

tcatggttcc tatgtttttt tatcataatt aaaagcaaaa ccatctggat cacctaacag   3960

tcagaggtca gtatctcagc gtgtgaatta tagaggaaat acagagagaa cctcttccac   4020

ttttactttt cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc gggttgagga   4080

ttggggctag ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt ggcgcggatt   4140

cttaggaacg ctgttctagc cggccccctc tccaggggtc gccgtggccg gcattatttc   4200

ctagttcttc ttgtaaccct gaggtgccag cgcggggagt gaggaggggt cagggggcta   4260

aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg ttgagatttc   4320

acaagcaatg cgagttgtaa aataccagct ctacaagaag ctaggctctg tgacggcata   4380

gttttcagta gctttatcac aatattcaca atggagaatt atatgacatg gtagcagaaa   4440

taggcccttt tatgtgttgc ttctatttta cctcaaattg tagatatagg gtaatcaata   4500

aaatccatcc atgcctttca cacactaagt                                    4530


<210>  4535
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  4535

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
    450                 455                 460


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
465                 470                 475


<210>  4536
<211>  3887
<212>  DNA
<213>  Homo sapiens

<400>  4536
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1980

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   2040

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttgt   2100

atgtggaagg cttgccagag gggattccct tccgaagccc tacctggttt ggaattccac   2160

gacttgaaag gatcgtccgc gggagtaata aaatcaagtt cgttgttaaa aaacctgaac   2220

tagttatttc ctacttgcct cctgggatgg ctagtaaaat aaacactaaa gctttgcagt   2280

cccccaaaag accacgaagt cctgggagta attcaaaggt tcctgaaatt gaggtcaccg   2340

tggaaggccc taataacaac aatcctcaaa cctcagctgt tcgaaccccg acccagacta   2400

acggttctaa cgttcccttc aagccacgag ggagagagtt ttcctttgag gcctggaatg   2460

ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt caatgagaaa tgtggggaag   2520

ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt atttgagtct ttcccggaag   2580

acttttatgt ggaaggctta cctgagggtg tgccattccg aagaccatcg acttttggca   2640

ttccgaggct ggagaagata ctcagaaaca aagccaaaat taagttcatc attaaaaagc   2700

ccgaaatgtt tgagacggcg attaaggaga gcacctcctc taagagccct cccagaaaaa   2760

taaattcatc acccaatgtt aatactactg catcaggtgt tgaagacctt aacatcattc   2820

aggtgacaat tccagatgat gataatgaaa gactctcgaa agttgaaaaa gctagacagc   2880

taagagaaca agtgaatgac ctctttagtc ggaaatttgg tgaagctatt ggtatgggtt   2940

ttcctgtgaa agttccctac aggaaaatca caattaaccc tggctgtgtg gtggttgatg   3000

gcatgccccc gggggtgtcc ttcaaagccc ccagctacct ggaaatcagc tccatgagaa   3060

ggatcttaga ctctgccgag tttatcaaat tcacggtcat tagaccattt ccaggacttg   3120

tgattaataa ccagctggtt gatcagagtg agtcagaagg ccccgtgata caagaatcag   3180

ctgaaccaag ccagttggaa gttccagcca cagaagaaat aaaagagact gatggaagct   3240

ctcagatcaa gcaagaacca gaccccacgt ggtagacctc ttccctccta ggcaaaacca   3300

tctggatcac ctaacagtca gaggtcagta tctcagcgtg tgaattatag aggaaataca   3360

gagagaacct cttccacttt tacttttcgt ccaaataaaa tgcatggtgt accagaagtt   3420

gaagatcggg ttgaggattg gggctagctc gatgacacta aggccccaac atcgcgggac   3480

ctgctgtggc gcggattctt aggaacgctg ttctagccgg ccccctctcc aggggtcgcc   3540

gtggccggca ttatttccta gttcttcttg taaccctgag gtgccagcgc ggggagtgag   3600

gaggggtcag ggggctaagg atgcaacctc tgacgttctg cgccttccta ggagagtctt   3660

acatgtgttg agatttcaca agcaatgcga gttgtaaaat accagctcta caagaagcta   3720

ggctctgtga cggcatagtt ttcagtagct ttatcacaat attcacaatg gagaattata   3780

tgacatggta gcagaaatag gcccttttat gtgttgcttc tattttacct caaattgtag   3840

atatagggta atcaataaaa tccatccatg cctttcacac actaagt                 3887


<210>  4537
<211>  957
<212>  PRT
<213>  Homo sapiens

<400>  4537

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
                565                 570                 575


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
            580                 585                 590


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
        595                 600                 605


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
    610                 615                 620


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
625                 630                 635                 640


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
                645                 650                 655


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
            660                 665                 670


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
        675                 680                 685


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
    690                 695                 700


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
705                 710                 715                 720


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
                725                 730                 735


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
            740                 745                 750


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
        755                 760                 765


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
    770                 775                 780


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
785                 790                 795                 800


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
                805                 810                 815


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
            820                 825                 830


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
        835                 840                 845


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
    850                 855                 860


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
865                 870                 875                 880


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
                885                 890                 895


Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu 
            900                 905                 910


Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu 
        915                 920                 925


Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp 
    930                 935                 940


Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950                 955


<210>  4538
<211>  5080
<212>  DNA
<213>  Homo sapiens

<400>  4538
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1980

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   2040

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttgt   2100

atgtggaagg cttgccagag gggattccct tccgaagccc tacctggttt ggaattccac   2160

gacttgaaag gatcgtccgc gggagtaata aaatcaagtt cgttgttaaa aaacctgaac   2220

tagttatttc ctacttgcct cctgggatgg ctagtaaaat aaacactaaa gctttgcagt   2280

cccccaaaag accacgaagt cctgggagta attcaaaggt tcctgaaatt gaggtcaccg   2340

tggaaggccc taataacaac aatcctcaaa cctcagctgt tcgaaccccg acccagacta   2400

acggttctaa cgttcccttc aagccacgag ggagagagtt ttcctttgag gcctggaatg   2460

ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt caatgagaaa tgtggggaag   2520

ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt atttgagtct ttcccggaag   2580

acttttatgt ggaaggctta cctgagggtg tgccattccg aagaccatcg acttttggca   2640

ttccgaggct ggagaagata ctcagaaaca aagccaaaat taagttcatc attaaaaagc   2700

ccgaaatgtt tgagacggcg attaaggaga gcacctcctc taagagccct cccagaaaaa   2760

taaattcatc acccaatgtt aatactactg catcaggtgt tgaagacctt aacatcattc   2820

aggtgacaat tccagatgat gataatgaaa gactctcgaa agttgaaaaa gctagacagc   2880

taagagaaca agtgaatgac ctctttagtc ggaaatttgg tgaagctatt ggtatgggtt   2940

ttcctgtgaa agttccctac aggaaaatca caattaaccc tggctgtgtg gtggttgatg   3000

gcatgccccc gggggtgtcc ttcaaagccc ccagctacct ggaaatcagc tccatgagaa   3060

ggatcttaga ctctgccgag tttatcaaat tcacggtcat tagaccattt ccaggacttg   3120

tgattaataa ccagctggtt gatcagagtg agtcagaagg ccccgtgata caagaatcag   3180

ctgaaccaag ccagttggaa gttccagcca cagaaggtaa aaggacctct tccctcctag   3240

ggtaaatcag cttctgtgtc agggatgctg tgtggtgtcc atctgaaccc cctgcatacg   3300

cgtagctaat gtgatctccc cactttcaca taagatggtg gccctgcctt cagggaatgt   3360

gggagccagg tgggagcctt cccggatatt taagctagaa gattctacag ggagattctc   3420

cttggatcaa tatatgtctc tcagtcaaag atgtaaaagc acttttgcct taaaaagaat   3480

gttctgtttc taaatagagt caacgttgtc ctcctcattg gaattcacta tgagtcagaa   3540

tcattagact gacttttttt tttccatagt aatagtattt tgcagagtct cacagagctg   3600

cagatctttt gttcatcttg cagagttaac aagtctgatc ctgttagtcc agatttctta   3660

aatttggcca agttataata ggagcagtag cttgagaccc gaagtcagga aactttgaca   3720

atggattttt ttttttaatc cagagacttg tactggaatt tgccttaccc tgtcagctca   3780

tggacttaag gtttcatccc gctttatgag tgcttctgaa tccaagtcat tgttacctga   3840

atttgcaaat taagttgtga tattcgtgac tgttaaattc ctgtaattag attaacctct   3900

ttgcttgctt gtttgttttc tctcctattt tagcttaaag tatcagtggt tgagaagagc   3960

ttttcggacc tgttactacc ccaagctgtg taatatactt gtataacaga aataccttct   4020

atacaaacct ttttttctac ttttagatag aaatgtctac tttttcagca gttctgtgaa   4080

ttaaagagca gagtgactgt gggtctggaa tggctggtgt acttgggaat gtactatcag   4140

gattttacag caatgctggg aaatgacagg gaaaatgaca ggaatgaatc tcaccagatt   4200

ttttatgtac tcagcagagc cttgagttac ggtgtttatt ttccaatcaa gtgaagatat   4260

ctcctacttc tcctactgga acatctcagc ttctgcagtg aagaaaaatt cctgtgatag   4320

ttcagttctt tagtttttct atttgaaaaa aaaaaatcat ttaaatgatc ctttgttcac   4380

ggctctcctt aatgactgag tgaacagttc ctatctgtat atttgactaa accttttcct   4440

aagctatctc tcatggttcc tatgtttttt tatcataatt aaaagcaaaa ccatctggat   4500

cacctaacag tcagaggtca gtatctcagc gtgtgaatta tagaggaaat acagagagaa   4560

cctcttccac ttttactttt cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc   4620

gggttgagga ttggggctag ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt   4680

ggcgcggatt cttaggaacg ctgttctagc cggccccctc tccaggggtc gccgtggccg   4740

gcattatttc ctagttcttc ttgtaaccct gaggtgccag cgcggggagt gaggaggggt   4800

cagggggcta aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg   4860

ttgagatttc acaagcaatg cgagttgtaa aataccagct ctacaagaag ctaggctctg   4920

tgacggcata gttttcagta gctttatcac aatattcaca atggagaatt atatgacatg   4980

gtagcagaaa taggcccttt tatgtgttgc ttctatttta cctcaaattg tagatatagg   5040

gtaatcaata aaatccatcc atgcctttca cacactaagt                         5080


<210>  4539
<211>  947
<212>  PRT
<213>  Homo sapiens

<400>  4539

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
                565                 570                 575


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
            580                 585                 590


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
        595                 600                 605


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
    610                 615                 620


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
625                 630                 635                 640


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
                645                 650                 655


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
            660                 665                 670


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
        675                 680                 685


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
    690                 695                 700


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
705                 710                 715                 720


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
                725                 730                 735


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
            740                 745                 750


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
        755                 760                 765


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
    770                 775                 780


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
785                 790                 795                 800


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
                805                 810                 815


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
            820                 825                 830


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
        835                 840                 845


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
    850                 855                 860


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
865                 870                 875                 880


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
                885                 890                 895


Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu 
            900                 905                 910


Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu 
        915                 920                 925


Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Gly Lys Arg Thr Ser Ser 
    930                 935                 940


Leu Leu Gly 
945


<210>  4540
<211>  7825
<212>  DNA
<213>  Homo sapiens

<400>  4540
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gctcaagctc ttggactcac   1980

cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct tgtatgtgga   2040

aggcttgcca gaggggattc ccttccgaag ccctacctgg tttggaattc cacgacttga   2100

aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg aactagttat   2160

ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc agtcccccaa   2220

aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg   2280

ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga ctaacggttc   2340

taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga atgccaaaat   2400

cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg   2460

ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg aagactttta   2520

tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg gcattccgag   2580

gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa agcccgaaat   2640

gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa aaataaattc   2700

atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca ttcaggtgac   2760

aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac agctaagaga   2820

acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg gttttcctgt   2880

gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg atggcatgcc   2940

cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga gaaggatctt   3000

agactctgcc gagtttatca aattcacggt cattaggtaa gtgagagttt cctgcttagt   3060

cacaggagcg aatctggagc tcatgaggct gactcttcta aaatgcagcc acaggtagtc   3120

atcgaatccg gcttcctatg ctgtgcaatc aacaaatcaa aataacttgt gtcatcatta   3180

gaatgtcaga tgtgcttcta cgaactaagc tgactctttt aattctttgg caaagggttg   3240

gcaaactagg actgtttgcc aaattcaggc tgcctcctat ttttagagtc ttcctgaaac   3300

acagctacac ccgtattatc catggctgct ttcctgtcac agtgagtaag tagctgggac   3360

tgagaaggca tggcctccaa agtctaaaat atttactctc tagcactttg tagaaaaacc   3420

ttagctaggc acagtggcta acgcctgtaa tcccagcatt ttgggaggcc aaggcaggca   3480

gatcacctga ggtcaggagt tccagaccag cctggccaac atggtgaaat cccatctcta   3540

caaaaataaa acagttagct gggcatgatg gcgggtgcct gtaatcccag ctactcggga   3600

ggctgaggca ggatagtcgc ttgaacccag gaggtggagg ttgcaatgag ccaagatcat   3660

gccactgcac tccagcctgg acgacagagt gagactccat cacaagaaaa aaagaacttt   3720

gtcaacctct gtcttagggc gccttgtcac aggcttcggg tcagacggat tcaaccttgc   3780

atcagccatt tgttagccag gtcactctgt tctttgtctg taaatgagat tgatcgttgt   3840

tcccactgag agtgtcagct ccttcccgta gagcaggcat gatgattgta ctcacctctg   3900

acaccattgt gagtgccaca ttccttccca cgtccttgtc actgtaagag atgcccacct   3960

gagcaccaac cccaggttat cttccccttt gtcttccagc cccccagaaa cagctacgac   4020

tcaacctacc caatcatttc atcatcagat tgccactgtc tctagttcag gtctcttggg   4080

actggcactc agaaatctca taataaatcc tcttgaggct tctcatacac tcgtcttctt   4140

ccaatcttct ttccctcaaa atctcatatt ttggttccac ttcacccacc gtcattctcc   4200

atatcactcc caggagttag gcaaaaagcc ccttccgttc ttccgtatgt taaacttaga   4260

atcactctgt tccctgctct gcgtttctat tttttgtttt tcctccattt actagtagct   4320

taacactttc taacagtgtt cttattattg atacgtatct atctcttcca taagcttata   4380

aggtcacgga taatacttct cattgtagta cgtaaatgac gtgggctaga tatgagttga   4440

ataaacagtt atacctgtaa attcttacag agtgaaaata aattgttata ctttacaatt   4500

tgtttctctc tttagaccat ttccaggact tgtgattaat aaccgtgagt attttgtgaa   4560

gtgttttgtt tttgtttttt cctggggtct gacgtgtgtg cgtgtgagtg tgtatacatg   4620

cttaacgtat atcacgttac ttcacctatg tcagtaacca ggccaaatac ttgttttagc   4680

cctcagtaaa aacaccaggc acttcctagt tgtaaaatta ttcaagcttc ttaacttcct   4740

atcctcgatg cacttaatca taaaatggta ataatagcac cgattttggg ggagtcgttc   4800

cagtagatgg aaagcatctg gaacaggtgt cagcaagctc ctgccgacgt gtatgcataa   4860

agttttattg aaaccaccat cgtgtccatt tgtttatggc agaactgaga gatggcagca   4920

gcaagtgtgt gcctgcaaaa cctaaaatat ttactaattg gctctgcaag aaaagagttt   4980

gcatccccct aacctagaac agtgtctagc ctctagtatg tgtttagcct acagtatgtg   5040

ctcagcgaat acaatctata tttattactg cttttatgac tgttataatt actgtgcttg   5100

gatttcgtta caaagtaagt cacaatgtgc ctgcttctgt tagtatttca gcacagtgcc   5160

tggcacacat ggggctctca aatattgctg agcgagtgaa caaatgtcct ttcaattcct   5220

taacgttgat gtcattttca atagtatttt gagccaaact taattttgcg agtgtgtttt   5280

gttttcttaa ctttattatt aaaaatgtat aaaagtgagg ccaggcgtgg tggctcacgc   5340

ctgtaatccc agcagtttgg gaggctgagg caggcggatc agttgaggtt gggagttgga   5400

gaccagcccg tccaacatgg tgaaagcctg tctctactaa aaatacaaaa atcagctggg   5460

tgtggtggcg cgtgcctgta atcccagcta ctcaggaggc tgaggcagga gagttgcttg   5520

aatcctagag gtggaggttg cagtgagctg agatcgtgcc attgcactcc agcctgggca   5580

acaagagcaa aactctgtcc caataaataa ataaataaaa tgttctcttt tgttcctgtt   5640

cttgtgcggt agtgtggtat agagttttat ggtaattact gtgaattagt gattctgagg   5700

gacatatcag aactctgagg tttgtttcct tctcatcttg agggaaacag caaatgtatg   5760

ttaaaatgct tttccaaggg aacaacacat ccttacatta tttaaaccaa tctgcttcat   5820

tttcagagct ggttgatcag agtgagtcag aaggccccgt gatacaagaa tcagctgaac   5880

caagccagtt ggaagttcca gccacagaag aaataaaaga gactgatgga agctctcaga   5940

tcaagcaaga accagacccc acgtggtaga cctcttccct cctagggtaa atcagcttct   6000

gtgtcaggga tgctgtgtgg tgtccatctg aaccccctgc atacgcgtag ctaatgtgat   6060

ctccccactt tcacataaga tggtggccct gccttcaggg aatgtgggag ccaggtggga   6120

gccttcccgg atatttaagc tagaagattc tacagggaga ttctccttgg atcaatatat   6180

gtctctcagt caaagatgta aaagcacttt tgccttaaaa agaatgttct gtttctaaat   6240

agagtcaacg ttgtcctcct cattggaatt cactatgagt cagaatcatt agactgactt   6300

ttttttttcc atagtaatag tattttgcag agtctcacag agctgcagat cttttgttca   6360

tcttgcagag ttaacaagtc tgatcctgtt agtccagatt tcttaaattt ggccaagtta   6420

taataggagc agtagcttga gacccgaagt caggaaactt tgacaatgga tttttttttt   6480

taatccagag acttgtactg gaatttgcct taccctgtca gctcatggac ttaaggtttc   6540

atcccgcttt atgagtgctt ctgaatccaa gtcattgtta cctgaatttg caaattaagt   6600

tgtgatattc gtgactgtta aattcctgta attagattaa cctctttgct tgcttgtttg   6660

ttttctctcc tattttagct taaagtatca gtggttgaga agagcttttc ggacctgtta   6720

ctaccccaag ctgtgtaata tacttgtata acagaaatac cttctataca aacctttttt   6780

tctactttta gatagaaatg tctacttttt cagcagttct gtgaattaaa gagcagagtg   6840

actgtgggtc tggaatggct ggtgtacttg ggaatgtact atcaggattt tacagcaatg   6900

ctgggaaatg acagggaaaa tgacaggaat gaatctcacc agatttttta tgtactcagc   6960

agagccttga gttacggtgt ttattttcca atcaagtgaa gatatctcct acttctccta   7020

ctggaacatc tcagcttctg cagtgaagaa aaattcctgt gatagttcag ttctttagtt   7080

tttctatttg aaaaaaaaaa atcatttaaa tgatcctttg ttcacggctc tccttaatga   7140

ctgagtgaac agttcctatc tgtatatttg actaaacctt ttcctaagct atctctcatg   7200

gttcctatgt ttttttatca taattaaaag caaaaccatc tggatcacct aacagtcaga   7260

ggtcagtatc tcagcgtgtg aattatagag gaaatacaga gagaacctct tccactttta   7320

cttttcgtcc aaataaaatg catggtgtac cagaagttga agatcgggtt gaggattggg   7380

gctagctcga tgacactaag gccccaacat cgcgggacct gctgtggcgc ggattcttag   7440

gaacgctgtt ctagccggcc ccctctccag gggtcgccgt ggccggcatt atttcctagt   7500

tcttcttgta accctgaggt gccagcgcgg ggagtgagga ggggtcaggg ggctaaggat   7560

gcaacctctg acgttctgcg ccttcctagg agagtcttac atgtgttgag atttcacaag   7620

caatgcgagt tgtaaaatac cagctctaca agaagctagg ctctgtgacg gcatagtttt   7680

cagtagcttt atcacaatat tcacaatgga gaattatatg acatggtagc agaaataggc   7740

ccttttatgt gttgcttcta ttttacctca aattgtagat atagggtaat caataaaatc   7800

catccatgcc tttcacacac taagt                                         7825


<210>  4541
<211>  872
<212>  PRT
<213>  Homo sapiens

<400>  4541

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro 
        515                 520                 525


Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu 
    530                 535                 540


Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu 
545                 550                 555                 560


Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro 
                565                 570                 575


Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn 
            580                 585                 590


Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn 
        595                 600                 605


Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn 
    610                 615                 620


Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser 
625                 630                 635                 640


Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp 
                645                 650                 655


Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn 
            660                 665                 670


Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro 
        675                 680                 685


Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu 
    690                 695                 700


Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg 
705                 710                 715                 720


Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys 
                725                 730                 735


Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys 
            740                 745                 750


Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala 
        755                 760                 765


Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp 
    770                 775                 780


Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu 
785                 790                 795                 800


Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met 
                805                 810                 815


Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly 
            820                 825                 830


Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro 
        835                 840                 845


Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu 
    850                 855                 860


Phe Ile Lys Phe Thr Val Ile Arg 
865                 870


<210>  4542
<211>  7741
<212>  DNA
<213>  Homo sapiens

<400>  4542
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1980

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   2040

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2100

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2160

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2220

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2280

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2340

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2400

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2460

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2520

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2580

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2640

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2700

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2760

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2820

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2880

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   2940

cacggtcatt aggtaagtga gagtttcctg cttagtcaca ggagcgaatc tggagctcat   3000

gaggctgact cttctaaaat gcagccacag gtagtcatcg aatccggctt cctatgctgt   3060

gcaatcaaca aatcaaaata acttgtgtca tcattagaat gtcagatgtg cttctacgaa   3120

ctaagctgac tcttttaatt ctttggcaaa gggttggcaa actaggactg tttgccaaat   3180

tcaggctgcc tcctattttt agagtcttcc tgaaacacag ctacacccgt attatccatg   3240

gctgctttcc tgtcacagtg agtaagtagc tgggactgag aaggcatggc ctccaaagtc   3300

taaaatattt actctctagc actttgtaga aaaaccttag ctaggcacag tggctaacgc   3360

ctgtaatccc agcattttgg gaggccaagg caggcagatc acctgaggtc aggagttcca   3420

gaccagcctg gccaacatgg tgaaatccca tctctacaaa aataaaacag ttagctgggc   3480

atgatggcgg gtgcctgtaa tcccagctac tcgggaggct gaggcaggat agtcgcttga   3540

acccaggagg tggaggttgc aatgagccaa gatcatgcca ctgcactcca gcctggacga   3600

cagagtgaga ctccatcaca agaaaaaaag aactttgtca acctctgtct tagggcgcct   3660

tgtcacaggc ttcgggtcag acggattcaa ccttgcatca gccatttgtt agccaggtca   3720

ctctgttctt tgtctgtaaa tgagattgat cgttgttccc actgagagtg tcagctcctt   3780

cccgtagagc aggcatgatg attgtactca cctctgacac cattgtgagt gccacattcc   3840

ttcccacgtc cttgtcactg taagagatgc ccacctgagc accaacccca ggttatcttc   3900

ccctttgtct tccagccccc cagaaacagc tacgactcaa cctacccaat catttcatca   3960

tcagattgcc actgtctcta gttcaggtct cttgggactg gcactcagaa atctcataat   4020

aaatcctctt gaggcttctc atacactcgt cttcttccaa tcttctttcc ctcaaaatct   4080

catattttgg ttccacttca cccaccgtca ttctccatat cactcccagg agttaggcaa   4140

aaagcccctt ccgttcttcc gtatgttaaa cttagaatca ctctgttccc tgctctgcgt   4200

ttctattttt tgtttttcct ccatttacta gtagcttaac actttctaac agtgttctta   4260

ttattgatac gtatctatct cttccataag cttataaggt cacggataat acttctcatt   4320

gtagtacgta aatgacgtgg gctagatatg agttgaataa acagttatac ctgtaaattc   4380

ttacagagtg aaaataaatt gttatacttt acaatttgtt tctctcttta gaccatttcc   4440

aggacttgtg attaataacc gtgagtattt tgtgaagtgt tttgtttttg ttttttcctg   4500

gggtctgacg tgtgtgcgtg tgagtgtgta tacatgctta acgtatatca cgttacttca   4560

cctatgtcag taaccaggcc aaatacttgt tttagccctc agtaaaaaca ccaggcactt   4620

cctagttgta aaattattca agcttcttaa cttcctatcc tcgatgcact taatcataaa   4680

atggtaataa tagcaccgat tttgggggag tcgttccagt agatggaaag catctggaac   4740

aggtgtcagc aagctcctgc cgacgtgtat gcataaagtt ttattgaaac caccatcgtg   4800

tccatttgtt tatggcagaa ctgagagatg gcagcagcaa gtgtgtgcct gcaaaaccta   4860

aaatatttac taattggctc tgcaagaaaa gagtttgcat ccccctaacc tagaacagtg   4920

tctagcctct agtatgtgtt tagcctacag tatgtgctca gcgaatacaa tctatattta   4980

ttactgcttt tatgactgtt ataattactg tgcttggatt tcgttacaaa gtaagtcaca   5040

atgtgcctgc ttctgttagt atttcagcac agtgcctggc acacatgggg ctctcaaata   5100

ttgctgagcg agtgaacaaa tgtcctttca attccttaac gttgatgtca ttttcaatag   5160

tattttgagc caaacttaat tttgcgagtg tgttttgttt tcttaacttt attattaaaa   5220

atgtataaaa gtgaggccag gcgtggtggc tcacgcctgt aatcccagca gtttgggagg   5280

ctgaggcagg cggatcagtt gaggttggga gttggagacc agcccgtcca acatggtgaa   5340

agcctgtctc tactaaaaat acaaaaatca gctgggtgtg gtggcgcgtg cctgtaatcc   5400

cagctactca ggaggctgag gcaggagagt tgcttgaatc ctagaggtgg aggttgcagt   5460

gagctgagat cgtgccattg cactccagcc tgggcaacaa gagcaaaact ctgtcccaat   5520

aaataaataa ataaaatgtt ctcttttgtt cctgttcttg tgcggtagtg tggtatagag   5580

ttttatggta attactgtga attagtgatt ctgagggaca tatcagaact ctgaggtttg   5640

tttccttctc atcttgaggg aaacagcaaa tgtatgttaa aatgcttttc caagggaaca   5700

acacatcctt acattattta aaccaatctg cttcattttc agagctggtt gatcagagtg   5760

agtcagaagg ccccgtgata caagaatcag ctgaaccaag ccagttggaa gttccagcca   5820

cagaagaaat aaaagagact gatggaagct ctcagatcaa gcaagaacca gaccccacgt   5880

ggtagacctc ttccctccta gggtaaatca gcttctgtgt cagggatgct gtgtggtgtc   5940

catctgaacc ccctgcatac gcgtagctaa tgtgatctcc ccactttcac ataagatggt   6000

ggccctgcct tcagggaatg tgggagccag gtgggagcct tcccggatat ttaagctaga   6060

agattctaca gggagattct ccttggatca atatatgtct ctcagtcaaa gatgtaaaag   6120

cacttttgcc ttaaaaagaa tgttctgttt ctaaatagag tcaacgttgt cctcctcatt   6180

ggaattcact atgagtcaga atcattagac tgactttttt ttttccatag taatagtatt   6240

ttgcagagtc tcacagagct gcagatcttt tgttcatctt gcagagttaa caagtctgat   6300

cctgttagtc cagatttctt aaatttggcc aagttataat aggagcagta gcttgagacc   6360

cgaagtcagg aaactttgac aatggatttt tttttttaat ccagagactt gtactggaat   6420

ttgccttacc ctgtcagctc atggacttaa ggtttcatcc cgctttatga gtgcttctga   6480

atccaagtca ttgttacctg aatttgcaaa ttaagttgtg atattcgtga ctgttaaatt   6540

cctgtaatta gattaacctc tttgcttgct tgtttgtttt ctctcctatt ttagcttaaa   6600

gtatcagtgg ttgagaagag cttttcggac ctgttactac cccaagctgt gtaatatact   6660

tgtataacag aaataccttc tatacaaacc tttttttcta cttttagata gaaatgtcta   6720

ctttttcagc agttctgtga attaaagagc agagtgactg tgggtctgga atggctggtg   6780

tacttgggaa tgtactatca ggattttaca gcaatgctgg gaaatgacag ggaaaatgac   6840

aggaatgaat ctcaccagat tttttatgta ctcagcagag ccttgagtta cggtgtttat   6900

tttccaatca agtgaagata tctcctactt ctcctactgg aacatctcag cttctgcagt   6960

gaagaaaaat tcctgtgata gttcagttct ttagtttttc tatttgaaaa aaaaaaatca   7020

tttaaatgat cctttgttca cggctctcct taatgactga gtgaacagtt cctatctgta   7080

tatttgacta aaccttttcc taagctatct ctcatggttc ctatgttttt ttatcataat   7140

taaaagcaaa accatctgga tcacctaaca gtcagaggtc agtatctcag cgtgtgaatt   7200

atagaggaaa tacagagaga acctcttcca cttttacttt tcgtccaaat aaaatgcatg   7260

gtgtaccaga agttgaagat cgggttgagg attggggcta gctcgatgac actaaggccc   7320

caacatcgcg ggacctgctg tggcgcggat tcttaggaac gctgttctag ccggccccct   7380

ctccaggggt cgccgtggcc ggcattattt cctagttctt cttgtaaccc tgaggtgcca   7440

gcgcggggag tgaggagggg tcagggggct aaggatgcaa cctctgacgt tctgcgcctt   7500

cctaggagag tcttacatgt gttgagattt cacaagcaat gcgagttgta aaataccagc   7560

tctacaagaa gctaggctct gtgacggcat agttttcagt agctttatca caatattcac   7620

aatggagaat tatatgacat ggtagcagaa ataggccctt ttatgtgttg cttctatttt   7680

acctcaaatt gtagatatag ggtaatcaat aaaatccatc catgcctttc acacactaag   7740

t                                                                   7741


<210>  4543
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  4543

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
            420                 425                 430


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
        435                 440                 445


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
    450                 455                 460


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser 
465                 470                 475                 480


Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
                485                 490                 495


<210>  4544
<211>  4328
<212>  DNA
<213>  Homo sapiens

<400>  4544
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gtcaaagaag attggaatgt   1980

cagaattacc aagctacgga agcaagtgga agagattttt aatttgaaat ttgcttagat   2040

ttgttgacag cggtttcctg gagtgctgtc ttgagaacga ttctgaggag gctcagcaag   2100

aaagagtgtt tcagttgatt gggtgtgtct gtcatggaga aggaactcaa gctcttggac   2160

tcaccgaggc agtaaaagta ccatatcctg tgtttgaatc aaacccggag ttcttgtatg   2220

tggaaggctt gccagagggg attcccttcc gaagccctac ctggtttgga attccacgac   2280

ttgaaaggat cgtccgcggg agtaataaaa tcaagttcgt tgttaaaaaa cctgaactag   2340

ttatttccta cttgcctcct gggatggcta gtaaaataaa cactaaagct ttgcagtccc   2400

ccaaaagacc acgaagtcct gggagtaatt caaaggttcc tgaaattgag gtcaccgtgg   2460

aaggccctaa taacaacaat cctcaaacct cagctgttcg aaccccgacc cagactaacg   2520

gttctaacgt tcccttcaag ccacgaggga gagagttttc ctttgaggcc tggaatgcca   2580

aaatcacgga cctaaaacag aaagttgaaa atctcttcaa tgagaaatgt ggggaagctc   2640

ttggccttaa acaagctgtg aaggtgccgt tcgcgttatt tgagtctttc ccggaagact   2700

tttatgtgga aggcttacct gagggtgtgc cattccgaag accatcgact tttggcattc   2760

cgaggctgga gaagatactc agaaacaaag ccaaaattaa gttcatcatt aaaaagcccg   2820

aaatgtttga gacggcgatt aaggagagca cctcctctaa gagccctccc agaaaaataa   2880

attcatcacc caatgttaat actactgcat caggtgttga agaccttaac atcattcagg   2940

tgacaattcc agatgatgat aatgaaagac tctcgaaagt tgaaaaagct agacagctaa   3000

gagaacaagt gaatgacctc tttagtcgga aatttggtga agctattggt atgggttttc   3060

ctgtgaaagt tccctacagg aaaatcacaa ttaaccctgg ctgtgtggtg gttgatggca   3120

tgcccccggg ggtgtccttc aaagccccca gctacctgga aatcagctcc atgagaagga   3180

tcttagactc tgccgagttt atcaaattca cggtcattag accatttcca ggacttgtga   3240

ttaataacca gctggttgat cagagtgagt cagaaggccc cgtgatacaa gaatcagctg   3300

aaccaagcca gttggaagtt ccagccacag aagaaataaa agagactgat ggaagctctc   3360

agatcaagca agaaccagac cccacgtggt agacctcttc cctcctaggc ttaaagtatc   3420

agtggttgag aagagctttt cggacctgtt actaccccaa gctgtagcct tgagttacgg   3480

tgtttatttt ccaatcaagt gaagatatct cctacttctc ctactggaac atctcagctt   3540

ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa   3600

aaaatcattt aaatgatcct ttgttcacgg ctctccttaa tgactgagtg aacagttcct   3660

atctgtatat ttgactaaac cttttcctaa gctatctctc atggttccta tgttttttta   3720

tcataattaa aagcaaaacc atctggatca cctaacagtc agaggtcagt atctcagcgt   3780

gtgaattata gaggaaatac agagagaacc tcttccactt ttacttttcg tccaaataaa   3840

atgcatggtg taccagaagt tgaagatcgg gttgaggatt ggggctagct cgatgacact   3900

aaggccccaa catcgcggga cctgctgtgg cgcggattct taggaacgct gttctagccg   3960

gccccctctc caggggtcgc cgtggccggc attatttcct agttcttctt gtaaccctga   4020

ggtgccagcg cggggagtga ggaggggtca gggggctaag gatgcaacct ctgacgttct   4080

gcgccttcct aggagagtct tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa   4140

taccagctct acaagaagct aggctctgtg acggcatagt tttcagtagc tttatcacaa   4200

tattcacaat ggagaattat atgacatggt agcagaaata ggccctttta tgtgttgctt   4260

ctattttacc tcaaattgta gatatagggt aatcaataaa atccatccat gcctttcaca   4320

cactaagt                                                            4328


<210>  4545
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  4545

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535


<210>  4546
<211>  5013
<212>  DNA
<213>  Homo sapiens

<400>  4546
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1980

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   2040

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttga   2100

aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg aactagttat   2160

ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc agtcccccaa   2220

aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg   2280

ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga ctaacggttc   2340

taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga atgccaaaat   2400

cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg   2460

ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg aagactttta   2520

tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg gcattccgag   2580

gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa agcccgaaat   2640

gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa aaataaattc   2700

atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca ttcaggtgac   2760

aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac agctaagaga   2820

acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg gttttcctgt   2880

gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg atggcatgcc   2940

cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga gaaggatctt   3000

agactctgcc gagtttatca aattcacggt cattagacca tttccaggac ttgtgattaa   3060

taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat cagctgaacc   3120

aagccagttg gaagttccag ccacagaagg taaaaggacc tcttccctcc tagggtaaat   3180

cagcttctgt gtcagggatg ctgtgtggtg tccatctgaa ccccctgcat acgcgtagct   3240

aatgtgatct ccccactttc acataagatg gtggccctgc cttcagggaa tgtgggagcc   3300

aggtgggagc cttcccggat atttaagcta gaagattcta cagggagatt ctccttggat   3360

caatatatgt ctctcagtca aagatgtaaa agcacttttg ccttaaaaag aatgttctgt   3420

ttctaaatag agtcaacgtt gtcctcctca ttggaattca ctatgagtca gaatcattag   3480

actgactttt ttttttccat agtaatagta ttttgcagag tctcacagag ctgcagatct   3540

tttgttcatc ttgcagagtt aacaagtctg atcctgttag tccagatttc ttaaatttgg   3600

ccaagttata ataggagcag tagcttgaga cccgaagtca ggaaactttg acaatggatt   3660

ttttttttta atccagagac ttgtactgga atttgcctta ccctgtcagc tcatggactt   3720

aaggtttcat cccgctttat gagtgcttct gaatccaagt cattgttacc tgaatttgca   3780

aattaagttg tgatattcgt gactgttaaa ttcctgtaat tagattaacc tctttgcttg   3840

cttgtttgtt ttctctccta ttttagctta aagtatcagt ggttgagaag agcttttcgg   3900

acctgttact accccaagct gtgtaatata cttgtataac agaaatacct tctatacaaa   3960

cctttttttc tacttttaga tagaaatgtc tactttttca gcagttctgt gaattaaaga   4020

gcagagtgac tgtgggtctg gaatggctgg tgtacttggg aatgtactat caggatttta   4080

cagcaatgct gggaaatgac agggaaaatg acaggaatga atctcaccag attttttatg   4140

tactcagcag agccttgagt tacggtgttt attttccaat caagtgaaga tatctcctac   4200

ttctcctact ggaacatctc agcttctgca gtgaagaaaa attcctgtga tagttcagtt   4260

ctttagtttt tctatttgaa aaaaaaaaat catttaaatg atcctttgtt cacggctctc   4320

cttaatgact gagtgaacag ttcctatctg tatatttgac taaacctttt cctaagctat   4380

ctctcatggt tcctatgttt ttttatcata attaaaagca aaaccatctg gatcacctaa   4440

cagtcagagg tcagtatctc agcgtgtgaa ttatagagga aatacagaga gaacctcttc   4500

cacttttact tttcgtccaa ataaaatgca tggtgtacca gaagttgaag atcgggttga   4560

ggattggggc tagctcgatg acactaaggc cccaacatcg cgggacctgc tgtggcgcgg   4620

attcttagga acgctgttct agccggcccc ctctccaggg gtcgccgtgg ccggcattat   4680

ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg   4740

ctaaggatgc aacctctgac gttctgcgcc ttcctaggag agtcttacat gtgttgagat   4800

ttcacaagca atgcgagttg taaaatacca gctctacaag aagctaggct ctgtgacggc   4860

atagttttca gtagctttat cacaatattc acaatggaga attatatgac atggtagcag   4920

aaataggccc ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat agggtaatca   4980

ataaaatcca tccatgcctt tcacacacta agt                                5013


<210>  4547
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  4547

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
                565                 570                 575


Ser Ser Leu Leu Lys Asn Leu Asn 
            580


<210>  4548
<211>  5195
<212>  DNA
<213>  Homo sapiens

<400>  4548
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   1980

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gcttagattt   2040

gttgacagcg gtttcctgga gtgctgtctt gagaacgatt ctgaggaggc tcagcaagaa   2100

agagtgtttc agttgattgg gtgtgtctgt catggagaag gaactcaagc tcttggactc   2160

accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgtatgtg   2220

gaaggcttgc cagaggggat tcccttccga agccctacct ggtttggaat tccacgactt   2280

gaaaggatcg tccgcgggag taataaaatc aagttcgttg ttaaaaaacc tgaactagtt   2340

atttcctact tgcctcctgg gatggctagt aaaataaaca ctaaagcttt gcagtccccc   2400

aaaagaccac gaagtcctgg gagtaattca aaggttcctg aaattgaggt caccgtggaa   2460

ggccctaata acaacaatcc tcaaacctca gctgttcgaa ccccgaccca gactaacggt   2520

tctaacgttc ccttcaagcc acgagggaga gagttttcct ttgaggcctg gaatgccaaa   2580

atcacggacc taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg ggaagctctt   2640

ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg agtctttccc ggaagacttt   2700

tatgtggaag gcttacctga gggtgtgcca ttccgaagac catcgacttt tggcattccg   2760

aggctggaga agatactcag aaacaaagcc aaaattaagt tcatcattaa aaagcccgaa   2820

atgtttgaga cggcgattaa ggagagcacc tcctctaaga gccctcccag aaaaataaat   2880

tcatcaccca atgttaatac tactgcatca ggtgttgaag accttaacat cattcaggtg   2940

acaattccag atgatgataa tgaaagactc tcgaaagttg aaaaagctag acagctaaga   3000

gaacaagtga atgacctctt tagtcggaaa tttggtgaag ctattggtat gggttttcct   3060

gtgaaagttc cctacaggaa aatcacaatt aaccctggct gtgtggtggt tgatggcatg   3120

cccccggggg tgtccttcaa agcccccagc tacctggaaa tcagctccat gagaaggatc   3180

ttagactctg ccgagtttat caaattcacg gtcattagac catttccagg acttgtgatt   3240

aataaccagc tggttgatca gagtgagtca gaaggccccg tgatacaaga atcagctgaa   3300

ccaagccagt tggaagttcc agccacagaa ggtaaaagga cctcttccct cctagggtaa   3360

atcagcttct gtgtcaggga tgctgtgtgg tgtccatctg aaccccctgc atacgcgtag   3420

ctaatgtgat ctccccactt tcacataaga tggtggccct gccttcaggg aatgtgggag   3480

ccaggtggga gccttcccgg atatttaagc tagaagattc tacagggaga ttctccttgg   3540

atcaatatat gtctctcagt caaagatgta aaagcacttt tgccttaaaa agaatgttct   3600

gtttctaaat agagtcaacg ttgtcctcct cattggaatt cactatgagt cagaatcatt   3660

agactgactt ttttttttcc atagtaatag tattttgcag agtctcacag agctgcagat   3720

cttttgttca tcttgcagag ttaacaagtc tgatcctgtt agtccagatt tcttaaattt   3780

ggccaagtta taataggagc agtagcttga gacccgaagt caggaaactt tgacaatgga   3840

tttttttttt taatccagag acttgtactg gaatttgcct taccctgtca gctcatggac   3900

ttaaggtttc atcccgcttt atgagtgctt ctgaatccaa gtcattgtta cctgaatttg   3960

caaattaagt tgtgatattc gtgactgtta aattcctgta attagattaa cctctttgct   4020

tgcttgtttg ttttctctcc tattttagct taaagtatca gtggttgaga agagcttttc   4080

ggacctgtta ctaccccaag ctgtgtaata tacttgtata acagaaatac cttctataca   4140

aacctttttt tctactttta gatagaaatg tctacttttt cagcagttct gtgaattaaa   4200

gagcagagtg actgtgggtc tggaatggct ggtgtacttg ggaatgtact atcaggattt   4260

tacagcaatg ctgggaaatg acagggaaaa tgacaggaat gaatctcacc agatttttta   4320

tgtactcagc agagccttga gttacggtgt ttattttcca atcaagtgaa gatatctcct   4380

acttctccta ctggaacatc tcagcttctg cagtgaagaa aaattcctgt gatagttcag   4440

ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa tgatcctttg ttcacggctc   4500

tccttaatga ctgagtgaac agttcctatc tgtatatttg actaaacctt ttcctaagct   4560

atctctcatg gttcctatgt ttttttatca taattaaaag caaaaccatc tggatcacct   4620

aacagtcaga ggtcagtatc tcagcgtgtg aattatagag gaaatacaga gagaacctct   4680

tccactttta cttttcgtcc aaataaaatg catggtgtac cagaagttga agatcgggtt   4740

gaggattggg gctagctcga tgacactaag gccccaacat cgcgggacct gctgtggcgc   4800

ggattcttag gaacgctgtt ctagccggcc ccctctccag gggtcgccgt ggccggcatt   4860

atttcctagt tcttcttgta accctgaggt gccagcgcgg ggagtgagga ggggtcaggg   4920

ggctaaggat gcaacctctg acgttctgcg ccttcctagg agagtcttac atgtgttgag   4980

atttcacaag caatgcgagt tgtaaaatac cagctctaca agaagctagg ctctgtgacg   5040

gcatagtttt cagtagcttt atcacaatat tcacaatgga gaattatatg acatggtagc   5100

agaaataggc ccttttatgt gttgcttcta ttttacctca aattgtagat atagggtaat   5160

caataaaatc catccatgcc tttcacacac taagt                              5195


<210>  4549
<211>  544
<212>  PRT
<213>  Homo sapiens

<400>  4549

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile 
        515                 520                 525


Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  4550
<211>  4115
<212>  DNA
<213>  Homo sapiens

<400>  4550
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agctcaagct cttggactca ccgaggcagt aaaagtacca tatcctgtgt   1980

ttgaatcaaa cccggagttc ttgtatgtgg aaggcttgcc agaggggatt cccttccgaa   2040

gccctacctg gtttggaatt ccacgacttg aaaggatcgt ccgcgggagt aataaaatca   2100

agttcgttgt taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta   2160

aaataaacac taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa   2220

aggttcctga aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag   2280

ctgttcgaac cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag   2340

agttttcctt tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc   2400

tcttcaatga gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg   2460

cgttatttga gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat   2520

tccgaagacc atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca   2580

aaattaagtt catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct   2640

cctctaagag ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag   2700

gtgttgaaga ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct   2760

cgaaagttga aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat   2820

ttggtgaagc tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta   2880

accctggctg tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct   2940

acctggaaat cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg   3000

tcattagacc atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag   3060

aaggccccgt gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag   3120

aaataaaaga gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga   3180

cctcttccct cctaggctta aagtatcagt ggttgagaag agcttttcgg acctgttact   3240

accccaagct gtagccttga gttacggtgt ttattttcca atcaagtgaa gatatctcct   3300

acttctccta ctggaacatc tcagcttctg cagtgaagaa aaattcctgt gatagttcag   3360

ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa tgatcctttg ttcacggctc   3420

tccttaatga ctgagtgaac agttcctatc tgtatatttg actaaacctt ttcctaagct   3480

atctctcatg gttcctatgt ttttttatca taattaaaag caaaaccatc tggatcacct   3540

aacagtcaga ggtcagtatc tcagcgtgtg aattatagag gaaatacaga gagaacctct   3600

tccactttta cttttcgtcc aaataaaatg catggtgtac cagaagttga agatcgggtt   3660

gaggattggg gctagctcga tgacactaag gccccaacat cgcgggacct gctgtggcgc   3720

ggattcttag gaacgctgtt ctagccggcc ccctctccag gggtcgccgt ggccggcatt   3780

atttcctagt tcttcttgta accctgaggt gccagcgcgg ggagtgagga ggggtcaggg   3840

ggctaaggat gcaacctctg acgttctgcg ccttcctagg agagtcttac atgtgttgag   3900

atttcacaag caatgcgagt tgtaaaatac cagctctaca agaagctagg ctctgtgacg   3960

gcatagtttt cagtagcttt atcacaatat tcacaatgga gaattatatg acatggtagc   4020

agaaataggc ccttttatgt gttgcttcta ttttacctca aattgtagat atagggtaat   4080

caataaaatc catccatgcc tttcacacac taagt                              4115


<210>  4551
<211>  864
<212>  PRT
<213>  Homo sapiens

<400>  4551

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro 
    450                 455                 460


Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu 
465                 470                 475                 480


Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu 
                485                 490                 495


Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro 
            500                 505                 510


Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn 
        515                 520                 525


Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn 
    530                 535                 540


Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn 
545                 550                 555                 560


Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser 
                565                 570                 575


Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp 
            580                 585                 590


Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn 
        595                 600                 605


Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro 
    610                 615                 620


Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu 
625                 630                 635                 640


Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg 
                645                 650                 655


Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys 
            660                 665                 670


Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys 
        675                 680                 685


Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala 
    690                 695                 700


Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp 
705                 710                 715                 720


Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu 
                725                 730                 735


Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met 
            740                 745                 750


Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly 
        755                 760                 765


Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro 
    770                 775                 780


Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu 
785                 790                 795                 800


Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn 
                805                 810                 815


Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu 
            820                 825                 830


Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys 
        835                 840                 845


Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
    850                 855                 860


<210>  4552
<211>  4194
<212>  DNA
<213>  Homo sapiens

<400>  4552
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   2040

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2100

taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2160

ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2220

ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2280

ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2340

ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2400

atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2460

agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2520

agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2580

tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2640

ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2700

tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2760

ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2820

atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2880

ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2940

tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   3000

ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   3060

tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3120

ttatcaaatt cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg   3180

atcagagtga gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag   3240

ttccagccac agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag   3300

accccacgtg gtagacctct tccctcctag gagccttgag ttacggtgtt tattttccaa   3360

tcaagtgaag atatctccta cttctcctac tggaacatct cagcttctgc agtgaagaaa   3420

aattcctgtg atagttcagt tctttagttt ttctatttga aaaaaaaaaa tcatttaaat   3480

gatcctttgt tcacggctct ccttaatgac tgagtgaaca gttcctatct gtatatttga   3540

ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt tttttatcat aattaaaagc   3600

aaaaccatct ggatcaccta acagtcagag gtcagtatct cagcgtgtga attatagagg   3660

aaatacagag agaacctctt ccacttttac ttttcgtcca aataaaatgc atggtgtacc   3720

agaagttgaa gatcgggttg aggattgggg ctagctcgat gacactaagg ccccaacatc   3780

gcgggacctg ctgtggcgcg gattcttagg aacgctgttc tagccggccc cctctccagg   3840

ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa ccctgaggtg ccagcgcggg   3900

gagtgaggag gggtcagggg gctaaggatg caacctctga cgttctgcgc cttcctagga   3960

gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc agctctacaa   4020

gaagctaggc tctgtgacgg catagttttc agtagcttta tcacaatatt cacaatggag   4080

aattatatga catggtagca gaaataggcc cttttatgtg ttgcttctat tttacctcaa   4140

attgtagata tagggtaatc aataaaatcc atccatgcct ttcacacact aagt         4194


<210>  4553
<211>  909
<212>  PRT
<213>  Homo sapiens

<400>  4553

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
465                 470                 475                 480


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
                485                 490                 495


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
            500                 505                 510


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
        515                 520                 525


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
    530                 535                 540


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
545                 550                 555                 560


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
                565                 570                 575


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
            580                 585                 590


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
        595                 600                 605


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
    610                 615                 620


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
625                 630                 635                 640


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
                645                 650                 655


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
            660                 665                 670


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
        675                 680                 685


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
    690                 695                 700


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
705                 710                 715                 720


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
                725                 730                 735


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
            740                 745                 750


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
        755                 760                 765


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
    770                 775                 780


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
785                 790                 795                 800


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
                805                 810                 815


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
            820                 825                 830


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
        835                 840                 845


Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu 
    850                 855                 860


Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu 
865                 870                 875                 880


Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp 
                885                 890                 895


Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
            900                 905


<210>  4554
<211>  4079
<212>  DNA
<213>  Homo sapiens

<400>  4554
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   2040

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2100

gaaatttgct tagatttgtt gacagcggtt tcctggagtg ctgtcttgag aacgattctg   2160

aggaggctca gcaagaaaga gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa   2220

ctcaagctct tggactcacc gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc   2280

cggagttctt gtatgtggaa ggcttgccag aggggattcc cttccgaagc cctacctggt   2340

ttggaattcc acgacttgaa aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta   2400

aaaaacctga actagttatt tcctacttgc ctcctgggat ggctagtaaa ataaacacta   2460

aagctttgca gtcccccaaa agaccacgaa gtcctgggag taattcaaag gttcctgaaa   2520

ttgaggtcac cgtggaaggc cctaataaca acaatcctca aacctcagct gttcgaaccc   2580

cgacccagac taacggttct aacgttccct tcaagccacg agggagagag ttttcctttg   2640

aggcctggaa tgccaaaatc acggacctaa aacagaaagt tgaaaatctc ttcaatgaga   2700

aatgtgggga agctcttggc cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt   2760

ctttcccgga agacttttat gtggaaggct tacctgaggg tgtgccattc cgaagaccat   2820

cgacttttgg cattccgagg ctggagaaga tactcagaaa caaagccaaa attaagttca   2880

tcattaaaaa gcccgaaatg tttgagacgg cgattaagga gagcacctcc tctaagagcc   2940

ctcccagaaa aataaattca tcacccaatg ttaatactac tgcatcaggt gttgaagacc   3000

ttaacatcat tcaggtgaca attccagatg atgataatga aagactctcg aaagttgaaa   3060

aagctagaca gctaagagaa caagtgaatg acctctttag tcggaaattt ggtgaagcta   3120

ttggtatggg ttttcctgtg aaagttccct acaggaaaat cacaattaac cctggctgtg   3180

tggtggttga tggcatgccc ccgggggtgt ccttcaaagc ccccagctac ctggaaatca   3240

gctccatgag aaggatctta gactctgccg agtttatcaa attcacggtc attagaccat   3300

ttccaggact tgtgattaat aaccagctgg ttgatcagag tgagtcagaa ggccccgtga   3360

tacaagaatc agctgaacca agccagttgg aagttccagc cacagaagaa ataaaagaga   3420

ctgatggaag ctctcagatc aagcaagaac cagaccccac gtggtagacc tcttccctcc   3480

taggcaaaac catctggatc acctaacagt cagaggtcag tatctcagcg tgtgaattat   3540

agaggaaata cagagagaac ctcttccact tttacttttc gtccaaataa aatgcatggt   3600

gtaccagaag ttgaagatcg ggttgaggat tggggctagc tcgatgacac taaggcccca   3660

acatcgcggg acctgctgtg gcgcggattc ttaggaacgc tgttctagcc ggccccctct   3720

ccaggggtcg ccgtggccgg cattatttcc tagttcttct tgtaaccctg aggtgccagc   3780

gcggggagtg aggaggggtc agggggctaa ggatgcaacc tctgacgttc tgcgccttcc   3840

taggagagtc ttacatgtgt tgagatttca caagcaatgc gagttgtaaa ataccagctc   3900

tacaagaagc taggctctgt gacggcatag ttttcagtag ctttatcaca atattcacaa   3960

tggagaatta tatgacatgg tagcagaaat aggccctttt atgtgttgct tctattttac   4020

ctcaaattgt agatataggg taatcaataa aatccatcca tgcctttcac acactaagt    4079


<210>  4555
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  4555

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala 



<210>  4556
<211>  5004
<212>  DNA
<213>  Homo sapiens

<400>  4556
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1920

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   1980

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttga   2040

aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg aactagttat   2100

ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc agtcccccaa   2160

aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg   2220

ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga ctaacggttc   2280

taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga atgccaaaat   2340

cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg   2400

ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg aagactttta   2460

tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg gcattccgag   2520

gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa agcccgaaat   2580

gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa aaataaattc   2640

atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca ttcaggtgac   2700

aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac agctaagaga   2760

acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg gttttcctgt   2820

gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg atggcatgcc   2880

cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga gaaggatctt   2940

agactctgcc gagtttatca aattcacggt cattagacca tttccaggac ttgtgattaa   3000

taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat cagctgaacc   3060

aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa gctctcagat   3120

caagcaagaa ccagacccca cgtggtagac ctcttccctc ctagggtaaa tcagcttctg   3180

tgtcagggat gctgtgtggt gtccatctga accccctgca tacgcgtagc taatgtgatc   3240

tccccacttt cacataagat ggtggccctg ccttcaggga atgtgggagc caggtgggag   3300

ccttcccgga tatttaagct agaagattct acagggagat tctccttgga tcaatatatg   3360

tctctcagtc aaagatgtaa aagcactttt gccttaaaaa gaatgttctg tttctaaata   3420

gagtcaacgt tgtcctcctc attggaattc actatgagtc agaatcatta gactgacttt   3480

tttttttcca tagtaatagt attttgcaga gtctcacaga gctgcagatc ttttgttcat   3540

cttgcagagt taacaagtct gatcctgtta gtccagattt cttaaatttg gccaagttat   3600

aataggagca gtagcttgag acccgaagtc aggaaacttt gacaatggat tttttttttt   3660

aatccagaga cttgtactgg aatttgcctt accctgtcag ctcatggact taaggtttca   3720

tcccgcttta tgagtgcttc tgaatccaag tcattgttac ctgaatttgc aaattaagtt   3780

gtgatattcg tgactgttaa attcctgtaa ttagattaac ctctttgctt gcttgtttgt   3840

tttctctcct attttagctt aaagtatcag tggttgagaa gagcttttcg gacctgttac   3900

taccccaagc tgtgtaatat acttgtataa cagaaatacc ttctatacaa accttttttt   3960

ctacttttag atagaaatgt ctactttttc agcagttctg tgaattaaag agcagagtga   4020

ctgtgggtct ggaatggctg gtgtacttgg gaatgtacta tcaggatttt acagcaatgc   4080

tgggaaatga cagggaaaat gacaggaatg aatctcacca gattttttat gtactcagca   4140

gagccttgag ttacggtgtt tattttccaa tcaagtgaag atatctccta cttctcctac   4200

tggaacatct cagcttctgc agtgaagaaa aattcctgtg atagttcagt tctttagttt   4260

ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt tcacggctct ccttaatgac   4320

tgagtgaaca gttcctatct gtatatttga ctaaaccttt tcctaagcta tctctcatgg   4380

ttcctatgtt tttttatcat aattaaaagc aaaaccatct ggatcaccta acagtcagag   4440

gtcagtatct cagcgtgtga attatagagg aaatacagag agaacctctt ccacttttac   4500

ttttcgtcca aataaaatgc atggtgtacc agaagttgaa gatcgggttg aggattgggg   4560

ctagctcgat gacactaagg ccccaacatc gcgggacctg ctgtggcgcg gattcttagg   4620

aacgctgttc tagccggccc cctctccagg ggtcgccgtg gccggcatta tttcctagtt   4680

cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg gctaaggatg   4740

caacctctga cgttctgcgc cttcctagga gagtcttaca tgtgttgaga tttcacaagc   4800

aatgcgagtt gtaaaatacc agctctacaa gaagctaggc tctgtgacgg catagttttc   4860

agtagcttta tcacaatatt cacaatggag aattatatga catggtagca gaaataggcc   4920

cttttatgtg ttgcttctat tttacctcaa attgtagata tagggtaatc aataaaatcc   4980

atccatgcct ttcacacact aagt                                          5004


<210>  4557
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  4557

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
            500                 505                 510


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
        515                 520                 525


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
    530                 535                 540


Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu 
545                 550                 555                 560


Lys Asn Leu Asn 



<210>  4558
<211>  4924
<212>  DNA
<213>  Homo sapiens

<400>  4558
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agctcaagct cttggactca ccgaggcagt aaaagtacca tatcctgtgt   1920

ttgaatcaaa cccggagttc ttgtatgtgg aaggcttgcc agaggggatt cccttccgaa   1980

gccctacctg gtttggaatt ccacgacttg aaaggatcgt ccgcgggagt aataaaatca   2040

agttcgttgt taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta   2100

aaataaacac taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa   2160

aggttcctga aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag   2220

ctgttcgaac cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag   2280

agttttcctt tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc   2340

tcttcaatga gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg   2400

cgttatttga gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat   2460

tccgaagacc atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca   2520

aaattaagtt catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct   2580

cctctaagag ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag   2640

gtgttgaaga ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct   2700

cgaaagttga aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat   2760

ttggtgaagc tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta   2820

accctggctg tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct   2880

acctggaaat cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg   2940

tcattagacc atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag   3000

aaggccccgt gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag   3060

gtaaaaggac ctcttccctc ctagggtaaa tcagcttctg tgtcagggat gctgtgtggt   3120

gtccatctga accccctgca tacgcgtagc taatgtgatc tccccacttt cacataagat   3180

ggtggccctg ccttcaggga atgtgggagc caggtgggag ccttcccgga tatttaagct   3240

agaagattct acagggagat tctccttgga tcaatatatg tctctcagtc aaagatgtaa   3300

aagcactttt gccttaaaaa gaatgttctg tttctaaata gagtcaacgt tgtcctcctc   3360

attggaattc actatgagtc agaatcatta gactgacttt tttttttcca tagtaatagt   3420

attttgcaga gtctcacaga gctgcagatc ttttgttcat cttgcagagt taacaagtct   3480

gatcctgtta gtccagattt cttaaatttg gccaagttat aataggagca gtagcttgag   3540

acccgaagtc aggaaacttt gacaatggat tttttttttt aatccagaga cttgtactgg   3600

aatttgcctt accctgtcag ctcatggact taaggtttca tcccgcttta tgagtgcttc   3660

tgaatccaag tcattgttac ctgaatttgc aaattaagtt gtgatattcg tgactgttaa   3720

attcctgtaa ttagattaac ctctttgctt gcttgtttgt tttctctcct attttagctt   3780

aaagtatcag tggttgagaa gagcttttcg gacctgttac taccccaagc tgtgtaatat   3840

acttgtataa cagaaatacc ttctatacaa accttttttt ctacttttag atagaaatgt   3900

ctactttttc agcagttctg tgaattaaag agcagagtga ctgtgggtct ggaatggctg   3960

gtgtacttgg gaatgtacta tcaggatttt acagcaatgc tgggaaatga cagggaaaat   4020

gacaggaatg aatctcacca gattttttat gtactcagca gagccttgag ttacggtgtt   4080

tattttccaa tcaagtgaag atatctccta cttctcctac tggaacatct cagcttctgc   4140

agtgaagaaa aattcctgtg atagttcagt tctttagttt ttctatttga aaaaaaaaaa   4200

tcatttaaat gatcctttgt tcacggctct ccttaatgac tgagtgaaca gttcctatct   4260

gtatatttga ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt tttttatcat   4320

aattaaaagc aaaaccatct ggatcaccta acagtcagag gtcagtatct cagcgtgtga   4380

attatagagg aaatacagag agaacctctt ccacttttac ttttcgtcca aataaaatgc   4440

atggtgtacc agaagttgaa gatcgggttg aggattgggg ctagctcgat gacactaagg   4500

ccccaacatc gcgggacctg ctgtggcgcg gattcttagg aacgctgttc tagccggccc   4560

cctctccagg ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa ccctgaggtg   4620

ccagcgcggg gagtgaggag gggtcagggg gctaaggatg caacctctga cgttctgcgc   4680

cttcctagga gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc   4740

agctctacaa gaagctaggc tctgtgacgg catagttttc agtagcttta tcacaatatt   4800

cacaatggag aattatatga catggtagca gaaataggcc cttttatgtg ttgcttctat   4860

tttacctcaa attgtagata tagggtaatc aataaaatcc atccatgcct ttcacacact   4920

aagt                                                                4924


<210>  4559
<211>  834
<212>  PRT
<213>  Homo sapiens

<400>  4559

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala 
            420                 425                 430


Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser 
        435                 440                 445


Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
    450                 455                 460


Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg 
465                 470                 475                 480


Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile 
                485                 490                 495


Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu 
            500                 505                 510


Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro 
        515                 520                 525


Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr 
    530                 535                 540


Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe 
545                 550                 555                 560


Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile 
                565                 570                 575


Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly 
            580                 585                 590


Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe 
        595                 600                 605


Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val 
    610                 615                 620


Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile 
625                 630                 635                 640


Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met 
                645                 650                 655


Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg 
            660                 665                 670


Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu 
        675                 680                 685


Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg 
    690                 695                 700


Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp 
705                 710                 715                 720


Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val 
                725                 730                 735


Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val 
            740                 745                 750


Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu 
        755                 760                 765


Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe 
    770                 775                 780


Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val 
785                 790                 795                 800


Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro 
                805                 810                 815


Ser Gln Leu Glu Val Pro Ala Thr Glu Gly Lys Arg Thr Ser Ser Leu 
            820                 825                 830


Leu Gly 



<210>  4560
<211>  8147
<212>  DNA
<213>  Homo sapiens

<400>  4560
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2100

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2160

tttgaaattt gcttagattt gttgacagcg gtttcctgga gtgctgtctt gagaacgatt   2220

ctgaggaggc tcagcaagaa agagtgtttc agttgattgg gtgtgtctgt catggagaag   2280

gaactcaagc tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa   2340

acccggagtt cttgtatgtg gaaggcttgc cagaggggat tcccttccga agccctacct   2400

ggtttggaat tccacgactt gaaaggatcg tccgcgggag taataaaatc aagttcgttg   2460

ttaaaaaacc tgaactagtt atttcctact tgcctcctgg gatggctagt aaaataaaca   2520

ctaaagcttt gcagtccccc aaaagaccac gaagtcctgg gagtaattca aaggttcctg   2580

aaattgaggt caccgtggaa ggccctaata acaacaatcc tcaaacctca gctgttcgaa   2640

ccccgaccca gactaacggt tctaacgttc ccttcaagcc acgagggaga gagttttcct   2700

ttgaggcctg gaatgccaaa atcacggacc taaaacagaa agttgaaaat ctcttcaatg   2760

agaaatgtgg ggaagctctt ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg   2820

agtctttccc ggaagacttt tatgtggaag gcttacctga gggtgtgcca ttccgaagac   2880

catcgacttt tggcattccg aggctggaga agatactcag aaacaaagcc aaaattaagt   2940

tcatcattaa aaagcccgaa atgtttgaga cggcgattaa ggagagcacc tcctctaaga   3000

gccctcccag aaaaataaat tcatcaccca atgttaatac tactgcatca ggtgttgaag   3060

accttaacat cattcaggtg acaattccag atgatgataa tgaaagactc tcgaaagttg   3120

aaaaagctag acagctaaga gaacaagtga atgacctctt tagtcggaaa tttggtgaag   3180

ctattggtat gggttttcct gtgaaagttc cctacaggaa aatcacaatt aaccctggct   3240

gtgtggtggt tgatggcatg cccccggggg tgtccttcaa agcccccagc tacctggaaa   3300

tcagctccat gagaaggatc ttagactctg ccgagtttat caaattcacg gtcattaggt   3360

aagtgagagt ttcctgctta gtcacaggag cgaatctgga gctcatgagg ctgactcttc   3420

taaaatgcag ccacaggtag tcatcgaatc cggcttccta tgctgtgcaa tcaacaaatc   3480

aaaataactt gtgtcatcat tagaatgtca gatgtgcttc tacgaactaa gctgactctt   3540

ttaattcttt ggcaaagggt tggcaaacta ggactgtttg ccaaattcag gctgcctcct   3600

atttttagag tcttcctgaa acacagctac acccgtatta tccatggctg ctttcctgtc   3660

acagtgagta agtagctggg actgagaagg catggcctcc aaagtctaaa atatttactc   3720

tctagcactt tgtagaaaaa ccttagctag gcacagtggc taacgcctgt aatcccagca   3780

ttttgggagg ccaaggcagg cagatcacct gaggtcagga gttccagacc agcctggcca   3840

acatggtgaa atcccatctc tacaaaaata aaacagttag ctgggcatga tggcgggtgc   3900

ctgtaatccc agctactcgg gaggctgagg caggatagtc gcttgaaccc aggaggtgga   3960

ggttgcaatg agccaagatc atgccactgc actccagcct ggacgacaga gtgagactcc   4020

atcacaagaa aaaaagaact ttgtcaacct ctgtcttagg gcgccttgtc acaggcttcg   4080

ggtcagacgg attcaacctt gcatcagcca tttgttagcc aggtcactct gttctttgtc   4140

tgtaaatgag attgatcgtt gttcccactg agagtgtcag ctccttcccg tagagcaggc   4200

atgatgattg tactcacctc tgacaccatt gtgagtgcca cattccttcc cacgtccttg   4260

tcactgtaag agatgcccac ctgagcacca accccaggtt atcttcccct ttgtcttcca   4320

gccccccaga aacagctacg actcaaccta cccaatcatt tcatcatcag attgccactg   4380

tctctagttc aggtctcttg ggactggcac tcagaaatct cataataaat cctcttgagg   4440

cttctcatac actcgtcttc ttccaatctt ctttccctca aaatctcata ttttggttcc   4500

acttcaccca ccgtcattct ccatatcact cccaggagtt aggcaaaaag ccccttccgt   4560

tcttccgtat gttaaactta gaatcactct gttccctgct ctgcgtttct attttttgtt   4620

tttcctccat ttactagtag cttaacactt tctaacagtg ttcttattat tgatacgtat   4680

ctatctcttc cataagctta taaggtcacg gataatactt ctcattgtag tacgtaaatg   4740

acgtgggcta gatatgagtt gaataaacag ttatacctgt aaattcttac agagtgaaaa   4800

taaattgtta tactttacaa tttgtttctc tctttagacc atttccagga cttgtgatta   4860

ataaccgtga gtattttgtg aagtgttttg tttttgtttt ttcctggggt ctgacgtgtg   4920

tgcgtgtgag tgtgtataca tgcttaacgt atatcacgtt acttcaccta tgtcagtaac   4980

caggccaaat acttgtttta gccctcagta aaaacaccag gcacttccta gttgtaaaat   5040

tattcaagct tcttaacttc ctatcctcga tgcacttaat cataaaatgg taataatagc   5100

accgattttg ggggagtcgt tccagtagat ggaaagcatc tggaacaggt gtcagcaagc   5160

tcctgccgac gtgtatgcat aaagttttat tgaaaccacc atcgtgtcca tttgtttatg   5220

gcagaactga gagatggcag cagcaagtgt gtgcctgcaa aacctaaaat atttactaat   5280

tggctctgca agaaaagagt ttgcatcccc ctaacctaga acagtgtcta gcctctagta   5340

tgtgtttagc ctacagtatg tgctcagcga atacaatcta tatttattac tgcttttatg   5400

actgttataa ttactgtgct tggatttcgt tacaaagtaa gtcacaatgt gcctgcttct   5460

gttagtattt cagcacagtg cctggcacac atggggctct caaatattgc tgagcgagtg   5520

aacaaatgtc ctttcaattc cttaacgttg atgtcatttt caatagtatt ttgagccaaa   5580

cttaattttg cgagtgtgtt ttgttttctt aactttatta ttaaaaatgt ataaaagtga   5640

ggccaggcgt ggtggctcac gcctgtaatc ccagcagttt gggaggctga ggcaggcgga   5700

tcagttgagg ttgggagttg gagaccagcc cgtccaacat ggtgaaagcc tgtctctact   5760

aaaaatacaa aaatcagctg ggtgtggtgg cgcgtgcctg taatcccagc tactcaggag   5820

gctgaggcag gagagttgct tgaatcctag aggtggaggt tgcagtgagc tgagatcgtg   5880

ccattgcact ccagcctggg caacaagagc aaaactctgt cccaataaat aaataaataa   5940

aatgttctct tttgttcctg ttcttgtgcg gtagtgtggt atagagtttt atggtaatta   6000

ctgtgaatta gtgattctga gggacatatc agaactctga ggtttgtttc cttctcatct   6060

tgagggaaac agcaaatgta tgttaaaatg cttttccaag ggaacaacac atccttacat   6120

tatttaaacc aatctgcttc attttcagag ctggttgatc agagtgagtc agaaggcccc   6180

gtgatacaag aatcagctga accaagccag ttggaagttc cagccacaga agaaataaaa   6240

gagactgatg gaagctctca gatcaagcaa gaaccagacc ccacgtggta gacctcttcc   6300

ctcctagggt aaatcagctt ctgtgtcagg gatgctgtgt ggtgtccatc tgaaccccct   6360

gcatacgcgt agctaatgtg atctccccac tttcacataa gatggtggcc ctgccttcag   6420

ggaatgtggg agccaggtgg gagccttccc ggatatttaa gctagaagat tctacaggga   6480

gattctcctt ggatcaatat atgtctctca gtcaaagatg taaaagcact tttgccttaa   6540

aaagaatgtt ctgtttctaa atagagtcaa cgttgtcctc ctcattggaa ttcactatga   6600

gtcagaatca ttagactgac tttttttttt ccatagtaat agtattttgc agagtctcac   6660

agagctgcag atcttttgtt catcttgcag agttaacaag tctgatcctg ttagtccaga   6720

tttcttaaat ttggccaagt tataatagga gcagtagctt gagacccgaa gtcaggaaac   6780

tttgacaatg gatttttttt tttaatccag agacttgtac tggaatttgc cttaccctgt   6840

cagctcatgg acttaaggtt tcatcccgct ttatgagtgc ttctgaatcc aagtcattgt   6900

tacctgaatt tgcaaattaa gttgtgatat tcgtgactgt taaattcctg taattagatt   6960

aacctctttg cttgcttgtt tgttttctct cctattttag cttaaagtat cagtggttga   7020

gaagagcttt tcggacctgt tactacccca agctgtgtaa tatacttgta taacagaaat   7080

accttctata caaacctttt tttctacttt tagatagaaa tgtctacttt ttcagcagtt   7140

ctgtgaatta aagagcagag tgactgtggg tctggaatgg ctggtgtact tgggaatgta   7200

ctatcaggat tttacagcaa tgctgggaaa tgacagggaa aatgacagga atgaatctca   7260

ccagattttt tatgtactca gcagagcctt gagttacggt gtttattttc caatcaagtg   7320

aagatatctc ctacttctcc tactggaaca tctcagcttc tgcagtgaag aaaaattcct   7380

gtgatagttc agttctttag tttttctatt tgaaaaaaaa aaatcattta aatgatcctt   7440

tgttcacggc tctccttaat gactgagtga acagttccta tctgtatatt tgactaaacc   7500

ttttcctaag ctatctctca tggttcctat gtttttttat cataattaaa agcaaaacca   7560

tctggatcac ctaacagtca gaggtcagta tctcagcgtg tgaattatag aggaaataca   7620

gagagaacct cttccacttt tacttttcgt ccaaataaaa tgcatggtgt accagaagtt   7680

gaagatcggg ttgaggattg gggctagctc gatgacacta aggccccaac atcgcgggac   7740

ctgctgtggc gcggattctt aggaacgctg ttctagccgg ccccctctcc aggggtcgcc   7800

gtggccggca ttatttccta gttcttcttg taaccctgag gtgccagcgc ggggagtgag   7860

gaggggtcag ggggctaagg atgcaacctc tgacgttctg cgccttccta ggagagtctt   7920

acatgtgttg agatttcaca agcaatgcga gttgtaaaat accagctcta caagaagcta   7980

ggctctgtga cggcatagtt ttcagtagct ttatcacaat attcacaatg gagaattata   8040

tgacatggta gcagaaatag gcccttttat gtgttgcttc tattttacct caaattgtag   8100

atatagggta atcaataaaa tccatccatg cctttcacac actaagt                 8147


<210>  4561
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  4561

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala 
            580


<210>  4562
<211>  4292
<212>  DNA
<213>  Homo sapiens

<400>  4562
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gctcaagctc ttggactcac cgaggcagta aaagtaccat   1920

atcctgtgtt tgaatcaaac ccggagttct tgtatgtgga aggcttgcca gaggggattc   1980

ccttccgaag ccctacctgg tttggaattc cacgacttga aaggatcgtc cgcgggagta   2040

ataaaatcaa gttcgttgtt aaaaaacctg aactagttat ttcctacttg cctcctggga   2100

tggctagtaa aataaacact aaagctttgc agtcccccaa aagaccacga agtcctggga   2160

gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg ccctaataac aacaatcctc   2220

aaacctcagc tgttcgaacc ccgacccaga ctaacggttc taacgttccc ttcaagccac   2280

gagggagaga gttttccttt gaggcctgga atgccaaaat cacggaccta aaacagaaag   2340

ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg   2400

tgccgttcgc gttatttgag tctttcccgg aagactttta tgtggaaggc ttacctgagg   2460

gtgtgccatt ccgaagacca tcgacttttg gcattccgag gctggagaag atactcagaa   2520

acaaagccaa aattaagttc atcattaaaa agcccgaaat gtttgagacg gcgattaagg   2580

agagcacctc ctctaagagc cctcccagaa aaataaattc atcacccaat gttaatacta   2640

ctgcatcagg tgttgaagac cttaacatca ttcaggtgac aattccagat gatgataatg   2700

aaagactctc gaaagttgaa aaagctagac agctaagaga acaagtgaat gacctcttta   2760

gtcggaaatt tggtgaagct attggtatgg gttttcctgt gaaagttccc tacaggaaaa   2820

tcacaattaa ccctggctgt gtggtggttg atggcatgcc cccgggggtg tccttcaaag   2880

cccccagcta cctggaaatc agctccatga gaaggatctt agactctgcc gagtttatca   2940

aattcacggt cattagacca tttccaggac ttgtgattaa taaccagctg gttgatcaga   3000

gtgagtcaga aggccccgtg atacaagaat cagctgaacc aagccagttg gaagttccag   3060

ccacagaaga aataaaagag actgatggaa gctctcagat caagcaagaa ccagacccca   3120

cgtggtagac ctcttccctc ctaggcttaa agtatcagtg gttgagaaga gcttttcgga   3180

cctgttacta ccccaagctg tgtaatatac ttgtataaca gaaatacctt ctatacaaac   3240

ctttttttct acttttagat agaaatgtct actttttcag cagttctgtg aattaaagag   3300

cagagtgact gtgggtctgg aatggctggt gtacttggga atgtactatc aggattttac   3360

agcaatgctg ggaaatgaca gggaaaatga caggaatgaa tctcaccaga ttttttatgt   3420

actcagcaga gccttgagtt acggtgttta ttttccaatc aagtgaagat atctcctact   3480

tctcctactg gaacatctca gcttctgcag tgaagaaaaa ttcctgtgat agttcagttc   3540

tttagttttt ctatttgaaa aaaaaaaatc atttaaatga tcctttgttc acggctctcc   3600

ttaatgactg agtgaacagt tcctatctgt atatttgact aaaccttttc ctaagctatc   3660

tctcatggtt cctatgtttt tttatcataa ttaaaagcaa aaccatctgg atcacctaac   3720

agtcagaggt cagtatctca gcgtgtgaat tatagaggaa atacagagag aacctcttcc   3780

acttttactt ttcgtccaaa taaaatgcat ggtgtaccag aagttgaaga tcgggttgag   3840

gattggggct agctcgatga cactaaggcc ccaacatcgc gggacctgct gtggcgcgga   3900

ttcttaggaa cgctgttcta gccggccccc tctccagggg tcgccgtggc cggcattatt   3960

tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc   4020

taaggatgca acctctgacg ttctgcgcct tcctaggaga gtcttacatg tgttgagatt   4080

tcacaagcaa tgcgagttgt aaaataccag ctctacaaga agctaggctc tgtgacggca   4140

tagttttcag tagctttatc acaatattca caatggagaa ttatatgaca tggtagcaga   4200

aataggccct tttatgtgtt gcttctattt tacctcaaat tgtagatata gggtaatcaa   4260

taaaatccat ccatgccttt cacacactaa gt                                 4292


<210>  4563
<211>  908
<212>  PRT
<213>  Homo sapiens

<400>  4563

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala 
                485                 490                 495


Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser 
            500                 505                 510


Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        515                 520                 525


Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg 
    530                 535                 540


Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile 
545                 550                 555                 560


Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu 
                565                 570                 575


Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro 
            580                 585                 590


Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr 
        595                 600                 605


Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe 
    610                 615                 620


Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile 
625                 630                 635                 640


Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly 
                645                 650                 655


Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe 
            660                 665                 670


Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val 
        675                 680                 685


Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile 
    690                 695                 700


Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met 
705                 710                 715                 720


Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg 
                725                 730                 735


Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu 
            740                 745                 750


Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg 
        755                 760                 765


Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp 
    770                 775                 780


Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val 
785                 790                 795                 800


Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val 
                805                 810                 815


Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu 
            820                 825                 830


Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe 
        835                 840                 845


Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val 
    850                 855                 860


Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro 
865                 870                 875                 880


Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly 
                885                 890                 895


Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
            900                 905


<210>  4564
<211>  7220
<212>  DNA
<213>  Homo sapiens

<400>  4564
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   1980

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2040

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2100

atcaaacccg gagttcttgt atgtggaagg cttgccagag gggattccct tccgaagccc   2160

tacctggttt ggaattccac gacttgaaag gatcgtccgc gggagtaata aaatcaagtt   2220

cgttgttaaa aaacctgaac tagttatttc ctacttgcct cctgggatgg ctagtaaaat   2280

aaacactaaa gctttgcagt cccccaaaag accacgaagt cctgggagta attcaaaggt   2340

tcctgaaatt gaggtcaccg tggaaggccc taataacaac aatcctcaaa cctcagctgt   2400

tcgaaccccg acccagacta acggttctaa cgttcccttc aagccacgag ggagagagtt   2460

ttcctttgag gcctggaatg ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt   2520

caatgagaaa tgtggggaag ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt   2580

atttgagtct ttcccggaag acttttatgt ggaaggctta cctgagggtg tgccattccg   2640

aagaccatcg acttttggca ttccgaggct ggagaagata ctcagaaaca aagccaaaat   2700

taagttcatc attaaaaagc ccgaaatgtt tgagacggcg attaaggaga gcacctcctc   2760

taagagccct cccagaaaaa taaattcatc acccaatgtt aatactactg catcaggtgt   2820

tgaagacctt aacatcattc aggtgacaat tccagatgat gataatgaaa gactctcgaa   2880

agttgaaaaa gctagacagc taagagaaca agtgaatgac ctctttagtc ggaaatttgg   2940

tgaagctatt ggtatgggtt ttcctgtgaa agttccctac aggaaaatca caattaaccc   3000

tggctgtgtg gtggttgatg gcatgccccc gggggtgtcc ttcaaagccc ccagctacct   3060

ggaaatcagc tccatgagaa ggatcttaga ctctgccgag tttatcaaat tcacggtcat   3120

taggtaagtg agagtttcct gcttagtcac aggagcgaat ctggagctca tgaggctgac   3180

tcttctaaaa tgcagccaca ggtagtcatc gaatccggct tcctatgctg tgcaatcaac   3240

aaatcaaaat aacttgtgtc atcattagaa tgtcagatgt gcttctacga actaagctga   3300

ctcttttaat tctttggcaa agggttggca aactaggact gtttgccaaa ttcaggctgc   3360

ctcctatttt tagagtcttc ctgaaacaca gctacacccg tattatccat ggctgctttc   3420

ctgtcacagt gagtaagtag ctgggactga gaaggcatgg cctccaaagt ctaaaatatt   3480

tactctctag cactttgtag aaaaacctta gctaggcaca gtggctaacg cctgtaatcc   3540

cagcattttg ggaggccaag gcaggcagat cacctgaggt caggagttcc agaccagcct   3600

ggccaacatg gtgaaatccc atctctacaa aaataaaaca gttagctggg catgatggcg   3660

ggtgcctgta atcccagcta ctcgggaggc tgaggcagga tagtcgcttg aacccaggag   3720

gtggaggttg caatgagcca agatcatgcc actgcactcc agcctggacg acagagtgag   3780

actccatcac aagaaaaaaa gaactttgtc aacctctgtc ttagggcgcc ttgtcacagg   3840

cttcgggtca gacggattca accttgcatc agccatttgt tagccaggtc actctgttct   3900

ttgtctgtaa atgagattga tcgttgttcc cactgagagt gtcagctcct tcccgtagag   3960

caggcatgat gattgtactc acctctgaca ccattgtgag tgccacattc cttcccacgt   4020

ccttgtcact gtaagagatg cccacctgag caccaacccc aggttatctt cccctttgtc   4080

ttccagcccc ccagaaacag ctacgactca acctacccaa tcatttcatc atcagattgc   4140

cactgtctct agttcaggtc tcttgggact ggcactcaga aatctcataa taaatcctct   4200

tgaggcttct catacactcg tcttcttcca atcttctttc cctcaaaatc tcatattttg   4260

gttccacttc acccaccgtc attctccata tcactcccag gagttaggca aaaagcccct   4320

tccgttcttc cgtatgttaa acttagaatc actctgttcc ctgctctgcg tttctatttt   4380

ttgtttttcc tccatttact agtagcttaa cactttctaa cagtgttctt attattgata   4440

cgtatctatc tcttccataa gcttataagg tcacggataa tacttctcat tgtagtacgt   4500

aaatgacgtg ggctagatat gagttgaata aacagttata cctgtaaatt cttacagagt   4560

gaaaataaat tgttatactt tacaatttgt ttctctcttt agaccatttc caggacttgt   4620

gattaataac cgtgagtatt ttgtgaagtg ttttgttttt gttttttcct ggggtctgac   4680

gtgtgtgcgt gtgagtgtgt atacatgctt aacgtatatc acgttacttc acctatgtca   4740

gtaaccaggc caaatacttg ttttagccct cagtaaaaac accaggcact tcctagttgt   4800

aaaattattc aagcttctta acttcctatc ctcgatgcac ttaatcataa aatggtaata   4860

atagcaccga ttttggggga gtcgttccag tagatggaaa gcatctggaa caggtgtcag   4920

caagctcctg ccgacgtgta tgcataaagt tttattgaaa ccaccatcgt gtccatttgt   4980

ttatggcaga actgagagat ggcagcagca agtgtgtgcc tgcaaaacct aaaatattta   5040

ctaattggct ctgcaagaaa agagtttgca tccccctaac ctagaacagt gtctagcctc   5100

tagtatgtgt ttagcctaca gtatgtgctc agcgaataca atctatattt attactgctt   5160

ttatgactgt tataattact gtgcttggat ttcgttacaa agtaagtcac aatgtgcctg   5220

cttctgttag tatttcagca cagtgcctgg cacacatggg gctctcaaat attgctgagc   5280

gagtgaacaa atgtcctttc aattccttaa cgttgatgtc attttcaata gtattttgag   5340

ccaaacttaa ttttgcgagt gtgttttgtt ttcttaactt tattattaaa aatgtataaa   5400

agtgaggcca ggcgtggtgg ctcacgcctg taatcccagc agtttgggag gctgaggcag   5460

gcggatcagt tgaggttggg agttggagac cagcccgtcc aacatggtga aagcctgtct   5520

ctactaaaaa tacaaaaatc agctgggtgt ggtggcgcgt gcctgtaatc ccagctactc   5580

aggaggctga ggcaggagag ttgcttgaat cctagaggtg gaggttgcag tgagctgaga   5640

tcgtgccatt gcactccagc ctgggcaaca agagcaaaac tctgtcccaa taaataaata   5700

aataaaatgt tctcttttgt tcctgttctt gtgcggtagt gtggtataga gttttatggt   5760

aattactgtg aattagtgat tctgagggac atatcagaac tctgaggttt gtttccttct   5820

catcttgagg gaaacagcaa atgtatgtta aaatgctttt ccaagggaac aacacatcct   5880

tacattattt aaaccaatct gcttcatttt cagagctggt tgatcagagt gagtcagaag   5940

gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc acagaagaaa   6000

taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg tggtagacct   6060

cttccctcct aggcttaaag tatcagtggt tgagaagagc ttttcggacc tgttactacc   6120

ccaagctgtg taatatactt gtataacaga aataccttct atacaaacct ttttttctac   6180

ttttagatag aaatgtctac tttttcagca gttctgtgaa ttaaagagca gagtgactgt   6240

gggtctggaa tggctggtgt acttgggaat gtactatcag gattttacag caatgctggg   6300

aaatgacagg gaaaatgaca ggaatgaatc tcaccagatt ttttatgtac tcagcagagc   6360

cttgagttac ggtgtttatt ttccaatcaa gtgaagatat ctcctacttc tcctactgga   6420

acatctcagc ttctgcagtg aagaaaaatt cctgtgatag ttcagttctt tagtttttct   6480

atttgaaaaa aaaaaatcat ttaaatgatc ctttgttcac ggctctcctt aatgactgag   6540

tgaacagttc ctatctgtat atttgactaa accttttcct aagctatctc tcatggttcc   6600

tatgtttttt tatcataatt aaaagcaaaa ccatctggat cacctaacag tcagaggtca   6660

gtatctcagc gtgtgaatta tagaggaaat acagagagaa cctcttccac ttttactttt   6720

cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc gggttgagga ttggggctag   6780

ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg   6840

ctgttctagc cggccccctc tccaggggtc gccgtggccg gcattatttc ctagttcttc   6900

ttgtaaccct gaggtgccag cgcggggagt gaggaggggt cagggggcta aggatgcaac   6960

ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg ttgagatttc acaagcaatg   7020

cgagttgtaa aataccagct ctacaagaag ctaggctctg tgacggcata gttttcagta   7080

gctttatcac aatattcaca atggagaatt atatgacatg gtagcagaaa taggcccttt   7140

tatgtgttgc ttctatttta cctcaaattg tagatatagg gtaatcaata aaatccatcc   7200

atgcctttca cacactaagt                                               7220


<210>  4565
<211>  901
<212>  PRT
<213>  Homo sapiens

<400>  4565

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
                565                 570                 575


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
            580                 585                 590


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
        595                 600                 605


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
    610                 615                 620


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
625                 630                 635                 640


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
                645                 650                 655


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
            660                 665                 670


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
        675                 680                 685


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
    690                 695                 700


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
705                 710                 715                 720


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
                725                 730                 735


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
            740                 745                 750


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
        755                 760                 765


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
    770                 775                 780


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
785                 790                 795                 800


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
                805                 810                 815


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
            820                 825                 830


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
        835                 840                 845


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
    850                 855                 860


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
865                 870                 875                 880


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
                885                 890                 895


Phe Thr Val Ile Arg 
            900


<210>  4566
<211>  4023
<212>  DNA
<213>  Homo sapiens

<400>  4566
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagctca agctcttgga ctcaccgagg   1920

cagtaaaagt accatatcct gtgtttgaat caaacccgga gttcttgtat gtggaaggct   1980

tgccagaggg gattcccttc cgaagcccta cctggtttgg aattccacga cttgaaagga   2040

tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa acctgaacta gttatttcct   2100

acttgcctcc tgggatggct agtaaaataa acactaaagc tttgcagtcc cccaaaagac   2160

cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta   2220

ataacaacaa tcctcaaacc tcagctgttc gaaccccgac ccagactaac ggttctaacg   2280

ttcccttcaa gccacgaggg agagagtttt cctttgaggc ctggaatgcc aaaatcacgg   2340

acctaaaaca gaaagttgaa aatctcttca atgagaaatg tggggaagct cttggcctta   2400

aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg   2460

aaggcttacc tgagggtgtg ccattccgaa gaccatcgac ttttggcatt ccgaggctgg   2520

agaagatact cagaaacaaa gccaaaatta agttcatcat taaaaagccc gaaatgtttg   2580

agacggcgat taaggagagc acctcctcta agagccctcc cagaaaaata aattcatcac   2640

ccaatgttaa tactactgca tcaggtgttg aagaccttaa catcattcag gtgacaattc   2700

cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta agagaacaag   2760

tgaatgacct ctttagtcgg aaatttggtg aagctattgg tatgggtttt cctgtgaaag   2820

ttccctacag gaaaatcaca attaaccctg gctgtgtggt ggttgatggc atgcccccgg   2880

gggtgtcctt caaagccccc agctacctgg aaatcagctc catgagaagg atcttagact   2940

ctgccgagtt tatcaaattc acggtcatta gaccatttcc aggacttgtg attaataacc   3000

agctggttga tcagagtgag tcagaaggcc ccgtgataca agaatcagct gaaccaagcc   3060

agttggaagt tccagccaca gaagaaataa aagagactga tggaagctct cagatcaagc   3120

aagaaccaga ccccacgtgg tagacctctt ccctcctagg agccttgagt tacggtgttt   3180

attttccaat caagtgaaga tatctcctac ttctcctact ggaacatctc agcttctgca   3240

gtgaagaaaa attcctgtga tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat   3300

catttaaatg atcctttgtt cacggctctc cttaatgact gagtgaacag ttcctatctg   3360

tatatttgac taaacctttt cctaagctat ctctcatggt tcctatgttt ttttatcata   3420

attaaaagca aaaccatctg gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa   3480

ttatagagga aatacagaga gaacctcttc cacttttact tttcgtccaa ataaaatgca   3540

tggtgtacca gaagttgaag atcgggttga ggattggggc tagctcgatg acactaaggc   3600

cccaacatcg cgggacctgc tgtggcgcgg attcttagga acgctgttct agccggcccc   3660

ctctccaggg gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac cctgaggtgc   3720

cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc   3780

ttcctaggag agtcttacat gtgttgagat ttcacaagca atgcgagttg taaaatacca   3840

gctctacaag aagctaggct ctgtgacggc atagttttca gtagctttat cacaatattc   3900

acaatggaga attatatgac atggtagcag aaataggccc ttttatgtgt tgcttctatt   3960

ttacctcaaa ttgtagatat agggtaatca ataaaatcca tccatgcctt tcacacacta   4020

agt                                                                 4023


<210>  4567
<211>  913
<212>  PRT
<213>  Homo sapiens

<400>  4567

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
            500                 505                 510


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
        515                 520                 525


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
    530                 535                 540


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
545                 550                 555                 560


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
                565                 570                 575


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
            580                 585                 590


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
        595                 600                 605


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
    610                 615                 620


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
625                 630                 635                 640


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
                645                 650                 655


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
            660                 665                 670


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
        675                 680                 685


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
    690                 695                 700


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
705                 710                 715                 720


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
                725                 730                 735


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
            740                 745                 750


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
        755                 760                 765


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
    770                 775                 780


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
785                 790                 795                 800


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
                805                 810                 815


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
            820                 825                 830


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
        835                 840                 845


Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile 
    850                 855                 860


Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln 
865                 870                 875                 880


Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile 
                885                 890                 895


Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr 
            900                 905                 910


Trp 



<210>  4568
<211>  3760
<212>  DNA
<213>  Homo sapiens

<400>  4568
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1920

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   1980

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttga   2040

aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg aactagttat   2100

ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc agtcccccaa   2160

aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg   2220

ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga ctaacggttc   2280

taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga atgccaaaat   2340

cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg   2400

ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg aagactttta   2460

tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg gcattccgag   2520

gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa agcccgaaat   2580

gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa aaataaattc   2640

atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca ttcaggtgac   2700

aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac agctaagaga   2760

acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg gttttcctgt   2820

gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg atggcatgcc   2880

cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga gaaggatctt   2940

agactctgcc gagtttatca aattcacggt cattagacca tttccaggac ttgtgattaa   3000

taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat cagctgaacc   3060

aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa gctctcagat   3120

caagcaagaa ccagacccca cgtggtagac ctcttccctc ctaggcaaaa ccatctggat   3180

cacctaacag tcagaggtca gtatctcagc gtgtgaatta tagaggaaat acagagagaa   3240

cctcttccac ttttactttt cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc   3300

gggttgagga ttggggctag ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt   3360

ggcgcggatt cttaggaacg ctgttctagc cggccccctc tccaggggtc gccgtggccg   3420

gcattatttc ctagttcttc ttgtaaccct gaggtgccag cgcggggagt gaggaggggt   3480

cagggggcta aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg   3540

ttgagatttc acaagcaatg cgagttgtaa aataccagct ctacaagaag ctaggctctg   3600

tgacggcata gttttcagta gctttatcac aatattcaca atggagaatt atatgacatg   3660

gtagcagaaa taggcccttt tatgtgttgc ttctatttta cctcaaattg tagatatagg   3720

gtaatcaata aaatccatcc atgcctttca cacactaagt                         3760


<210>  4569
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  4569

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
            500                 505                 510


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
        515                 520                 525


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
    530                 535                 540


Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu 
545                 550                 555                 560


Lys Asn Leu Asn 



<210>  4570
<211>  4214
<212>  DNA
<213>  Homo sapiens

<400>  4570
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   1980

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2040

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2100

tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg tttggaattc   2160

cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg   2220

aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc   2280

agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca   2340

ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga   2400

ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga   2460

atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg   2520

aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg   2580

aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg   2640

gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa   2700

agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa   2760

aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca   2820

ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac   2880

agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg   2940

gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg   3000

atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga   3060

gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca tttccaggac   3120

ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat   3180

cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa   3240

gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc ctaggcttaa   3300

agtatcagtg gttgagaaga gcttttcgga cctgttacta ccccaagctg tagccttgag   3360

ttacggtgtt tattttccaa tcaagtgaag atatctccta cttctcctac tggaacatct   3420

cagcttctgc agtgaagaaa aattcctgtg atagttcagt tctttagttt ttctatttga   3480

aaaaaaaaaa tcatttaaat gatcctttgt tcacggctct ccttaatgac tgagtgaaca   3540

gttcctatct gtatatttga ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt   3600

tttttatcat aattaaaagc aaaaccatct ggatcaccta acagtcagag gtcagtatct   3660

cagcgtgtga attatagagg aaatacagag agaacctctt ccacttttac ttttcgtcca   3720

aataaaatgc atggtgtacc agaagttgaa gatcgggttg aggattgggg ctagctcgat   3780

gacactaagg ccccaacatc gcgggacctg ctgtggcgcg gattcttagg aacgctgttc   3840

tagccggccc cctctccagg ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa   3900

ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg gctaaggatg caacctctga   3960

cgttctgcgc cttcctagga gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt   4020

gtaaaatacc agctctacaa gaagctaggc tctgtgacgg catagttttc agtagcttta   4080

tcacaatatt cacaatggag aattatatga catggtagca gaaataggcc cttttatgtg   4140

ttgcttctat tttacctcaa attgtagata tagggtaatc aataaaatcc atccatgcct   4200

ttcacacact aagt                                                     4214


<210>  4571
<211>  958
<212>  PRT
<213>  Homo sapiens

<400>  4571

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile 
        515                 520                 525


Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
545                 550                 555                 560


Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile 
                565                 570                 575


Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile 
            580                 585                 590


Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu 
        595                 600                 605


Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys 
    610                 615                 620


Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys 
625                 630                 635                 640


Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro 
                645                 650                 655


Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val 
            660                 665                 670


Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala 
        675                 680                 685


Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys 
    690                 695                 700


Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala 
705                 710                 715                 720


Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu 
                725                 730                 735


Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu 
            740                 745                 750


Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro 
        755                 760                 765


Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro 
    770                 775                 780


Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly 
785                 790                 795                 800


Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn 
                805                 810                 815


Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val 
            820                 825                 830


Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe 
        835                 840                 845


Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val 
    850                 855                 860


Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr 
865                 870                 875                 880


Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile 
                885                 890                 895


Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln 
            900                 905                 910


Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala 
        915                 920                 925


Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr 
    930                 935                 940


Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950                 955


<210>  4572
<211>  4452
<212>  DNA
<213>  Homo sapiens

<400>  4572
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   2040

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2100

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2160

atcaaacccg gagttcttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2220

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2280

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2340

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2400

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2460

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2520

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2580

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2640

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2700

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2760

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2820

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2880

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2940

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   3000

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3060

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca   3120

tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg   3180

atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag   3240

actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc   3300

ctaggcttaa agtatcagtg gttgagaaga gcttttcgga cctgttacta ccccaagctg   3360

tgtaatatac ttgtataaca gaaatacctt ctatacaaac ctttttttct acttttagat   3420

agaaatgtct actttttcag cagttctgtg aattaaagag cagagtgact gtgggtctgg   3480

aatggctggt gtacttggga atgtactatc aggattttac agcaatgctg ggaaatgaca   3540

gggaaaatga caggaatgaa tctcaccaga ttttttatgt actcagcaga gccttgagtt   3600

acggtgttta ttttccaatc aagtgaagat atctcctact tctcctactg gaacatctca   3660

gcttctgcag tgaagaaaaa ttcctgtgat agttcagttc tttagttttt ctatttgaaa   3720

aaaaaaaatc atttaaatga tcctttgttc acggctctcc ttaatgactg agtgaacagt   3780

tcctatctgt atatttgact aaaccttttc ctaagctatc tctcatggtt cctatgtttt   3840

tttatcataa ttaaaagcaa aaccatctgg atcacctaac agtcagaggt cagtatctca   3900

gcgtgtgaat tatagaggaa atacagagag aacctcttcc acttttactt ttcgtccaaa   3960

taaaatgcat ggtgtaccag aagttgaaga tcgggttgag gattggggct agctcgatga   4020

cactaaggcc ccaacatcgc gggacctgct gtggcgcgga ttcttaggaa cgctgttcta   4080

gccggccccc tctccagggg tcgccgtggc cggcattatt tcctagttct tcttgtaacc   4140

ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc taaggatgca acctctgacg   4200

ttctgcgcct tcctaggaga gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt   4260

aaaataccag ctctacaaga agctaggctc tgtgacggca tagttttcag tagctttatc   4320

acaatattca caatggagaa ttatatgaca tggtagcaga aataggccct tttatgtgtt   4380

gcttctattt tacctcaaat tgtagatata gggtaatcaa taaaatccat ccatgccttt   4440

cacacactaa gt                                                       4452


<210>  4573
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  4573

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
                565                 570                 575


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly 
            580                 585                 590


Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600


<210>  4574
<211>  3967
<212>  DNA
<213>  Homo sapiens

<400>  4574
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   2040

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2100

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2160

atcaaacccg gagttcttgt atgtggaagg cttgccagag gggattccct tccgaagccc   2220

tacctggttt ggaattccac gacttgaaag gatcgtccgc gggagtaata aaatcaagtt   2280

cgttgttaaa aaacctgaac tagttatttc ctacttgcct cctgggatgg ctagtaaaat   2340

aaacactaaa gctttgcagt cccccaaaag accacgaagt cctgggagta attcaaaggt   2400

tcctgaaatt gaggtcaccg tggaaggccc taataacaac aatcctcaaa cctcagctgt   2460

tcgaaccccg acccagacta acggttctaa cgttcccttc aagccacgag ggagagagtt   2520

ttcctttgag gcctggaatg ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt   2580

caatgagaaa tgtggggaag ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt   2640

atttgagtct ttcccggaag acttttatgt ggaaggctta cctgagggtg tgccattccg   2700

aagaccatcg acttttggca ttccgaggct ggagaagata ctcagaaaca aagccaaaat   2760

taagttcatc attaaaaagc ccgaaatgtt tgagacggcg attaaggaga gcacctcctc   2820

taagagccct cccagaaaaa taaattcatc acccaatgtt aatactactg catcaggtgt   2880

tgaagacctt aacatcattc aggtgacaat tccagatgat gataatgaaa gactctcgaa   2940

agttgaaaaa gctagacagc taagagaaca agtgaatgac ctctttagtc ggaaatttgg   3000

tgaagctatt ggtatgggtt ttcctgtgaa agttccctac aggaaaatca caattaaccc   3060

tggctgtgtg gtggttgatg gcatgccccc gggggtgtcc ttcaaagccc ccagctacct   3120

ggaaatcagc tccatgagaa ggatcttaga ctctgccgag tttatcaaat tcacggtcat   3180

tagaccattt ccaggacttg tgattaataa ccagctggtt gatcagagtg agtcagaagg   3240

ccccgtgata caagaatcag ctgaaccaag ccagttggaa gttccagcca cagaagaaat   3300

aaaagagact gatggaagct ctcagatcaa gcaagaacca gaccccacgt ggtagacctc   3360

ttccctccta ggcaaaacca tctggatcac ctaacagtca gaggtcagta tctcagcgtg   3420

tgaattatag aggaaataca gagagaacct cttccacttt tacttttcgt ccaaataaaa   3480

tgcatggtgt accagaagtt gaagatcggg ttgaggattg gggctagctc gatgacacta   3540

aggccccaac atcgcgggac ctgctgtggc gcggattctt aggaacgctg ttctagccgg   3600

ccccctctcc aggggtcgcc gtggccggca ttatttccta gttcttcttg taaccctgag   3660

gtgccagcgc ggggagtgag gaggggtcag ggggctaagg atgcaacctc tgacgttctg   3720

cgccttccta ggagagtctt acatgtgttg agatttcaca agcaatgcga gttgtaaaat   3780

accagctcta caagaagcta ggctctgtga cggcatagtt ttcagtagct ttatcacaat   3840

attcacaatg gagaattata tgacatggta gcagaaatag gcccttttat gtgttgcttc   3900

tattttacct caaattgtag atatagggta atcaataaaa tccatccatg cctttcacac   3960

actaagt                                                             3967


<210>  4575
<211>  977
<212>  PRT
<213>  Homo sapiens

<400>  4575

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
                565                 570                 575


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
            580                 585                 590


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
        595                 600                 605


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
    610                 615                 620


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
625                 630                 635                 640


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
                645                 650                 655


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
            660                 665                 670


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
        675                 680                 685


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
    690                 695                 700


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
705                 710                 715                 720


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
                725                 730                 735


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
            740                 745                 750


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
        755                 760                 765


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
    770                 775                 780


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
785                 790                 795                 800


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
                805                 810                 815


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
            820                 825                 830


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
        835                 840                 845


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
    850                 855                 860


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
865                 870                 875                 880


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
                885                 890                 895


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
            900                 905                 910


Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile 
        915                 920                 925


Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln 
    930                 935                 940


Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile 
945                 950                 955                 960


Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr 
                965                 970                 975


Trp 



<210>  4576
<211>  4343
<212>  DNA
<213>  Homo sapiens

<400>  4576
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   1980

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2040

gaaatttgct tagatttgtt gacagcggtt tcctggagtg ctgtcttgag aacgattctg   2100

aggaggctca gcaagaaaga gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa   2160

ctcaagctct tggactcacc gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc   2220

cggagttctt gtatgtggaa ggcttgccag aggggattcc cttccgaagc cctacctggt   2280

ttggaattcc acgacttgaa aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta   2340

aaaaacctga actagttatt tcctacttgc ctcctgggat ggctagtaaa ataaacacta   2400

aagctttgca gtcccccaaa agaccacgaa gtcctgggag taattcaaag gttcctgaaa   2460

ttgaggtcac cgtggaaggc cctaataaca acaatcctca aacctcagct gttcgaaccc   2520

cgacccagac taacggttct aacgttccct tcaagccacg agggagagag ttttcctttg   2580

aggcctggaa tgccaaaatc acggacctaa aacagaaagt tgaaaatctc ttcaatgaga   2640

aatgtgggga agctcttggc cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt   2700

ctttcccgga agacttttat gtggaaggct tacctgaggg tgtgccattc cgaagaccat   2760

cgacttttgg cattccgagg ctggagaaga tactcagaaa caaagccaaa attaagttca   2820

tcattaaaaa gcccgaaatg tttgagacgg cgattaagga gagcacctcc tctaagagcc   2880

ctcccagaaa aataaattca tcacccaatg ttaatactac tgcatcaggt gttgaagacc   2940

ttaacatcat tcaggtgaca attccagatg atgataatga aagactctcg aaagttgaaa   3000

aagctagaca gctaagagaa caagtgaatg acctctttag tcggaaattt ggtgaagcta   3060

ttggtatggg ttttcctgtg aaagttccct acaggaaaat cacaattaac cctggctgtg   3120

tggtggttga tggcatgccc ccgggggtgt ccttcaaagc ccccagctac ctggaaatca   3180

gctccatgag aaggatctta gactctgccg agtttatcaa attcacggtc attagaccat   3240

ttccaggact tgtgattaat aaccagctgg ttgatcagag tgagtcagaa ggccccgtga   3300

tacaagaatc agctgaacca agccagttgg aagttccagc cacagaagaa ataaaagaga   3360

ctgatggaag ctctcagatc aagcaagaac cagaccccac gtggtagacc tcttccctcc   3420

taggcttaaa gtatcagtgg ttgagaagag cttttcggac ctgttactac cccaagctgt   3480

agccttgagt tacggtgttt attttccaat caagtgaaga tatctcctac ttctcctact   3540

ggaacatctc agcttctgca gtgaagaaaa attcctgtga tagttcagtt ctttagtttt   3600

tctatttgaa aaaaaaaaat catttaaatg atcctttgtt cacggctctc cttaatgact   3660

gagtgaacag ttcctatctg tatatttgac taaacctttt cctaagctat ctctcatggt   3720

tcctatgttt ttttatcata attaaaagca aaaccatctg gatcacctaa cagtcagagg   3780

tcagtatctc agcgtgtgaa ttatagagga aatacagaga gaacctcttc cacttttact   3840

tttcgtccaa ataaaatgca tggtgtacca gaagttgaag atcgggttga ggattggggc   3900

tagctcgatg acactaaggc cccaacatcg cgggacctgc tgtggcgcgg attcttagga   3960

acgctgttct agccggcccc ctctccaggg gtcgccgtgg ccggcattat ttcctagttc   4020

ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc   4080

aacctctgac gttctgcgcc ttcctaggag agtcttacat gtgttgagat ttcacaagca   4140

atgcgagttg taaaatacca gctctacaag aagctaggct ctgtgacggc atagttttca   4200

gtagctttat cacaatattc acaatggaga attatatgac atggtagcag aaataggccc   4260

ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat agggtaatca ataaaatcca   4320

tccatgcctt tcacacacta agt                                           4343


<210>  4577
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  4577

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  4578
<211>  3827
<212>  DNA
<213>  Homo sapiens

<400>  4578
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1920

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   1980

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttgt   2040

atgtggaagg cttgccagag gggattccct tccgaagccc tacctggttt ggaattccac   2100

gacttgaaag gatcgtccgc gggagtaata aaatcaagtt cgttgttaaa aaacctgaac   2160

tagttatttc ctacttgcct cctgggatgg ctagtaaaat aaacactaaa gctttgcagt   2220

cccccaaaag accacgaagt cctgggagta attcaaaggt tcctgaaatt gaggtcaccg   2280

tggaaggccc taataacaac aatcctcaaa cctcagctgt tcgaaccccg acccagacta   2340

acggttctaa cgttcccttc aagccacgag ggagagagtt ttcctttgag gcctggaatg   2400

ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt caatgagaaa tgtggggaag   2460

ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt atttgagtct ttcccggaag   2520

acttttatgt ggaaggctta cctgagggtg tgccattccg aagaccatcg acttttggca   2580

ttccgaggct ggagaagata ctcagaaaca aagccaaaat taagttcatc attaaaaagc   2640

ccgaaatgtt tgagacggcg attaaggaga gcacctcctc taagagccct cccagaaaaa   2700

taaattcatc acccaatgtt aatactactg catcaggtgt tgaagacctt aacatcattc   2760

aggtgacaat tccagatgat gataatgaaa gactctcgaa agttgaaaaa gctagacagc   2820

taagagaaca agtgaatgac ctctttagtc ggaaatttgg tgaagctatt ggtatgggtt   2880

ttcctgtgaa agttccctac aggaaaatca caattaaccc tggctgtgtg gtggttgatg   2940

gcatgccccc gggggtgtcc ttcaaagccc ccagctacct ggaaatcagc tccatgagaa   3000

ggatcttaga ctctgccgag tttatcaaat tcacggtcat tagaccattt ccaggacttg   3060

tgattaataa ccagctggtt gatcagagtg agtcagaagg ccccgtgata caagaatcag   3120

ctgaaccaag ccagttggaa gttccagcca cagaagaaat aaaagagact gatggaagct   3180

ctcagatcaa gcaagaacca gaccccacgt ggtagacctc ttccctccta ggcaaaacca   3240

tctggatcac ctaacagtca gaggtcagta tctcagcgtg tgaattatag aggaaataca   3300

gagagaacct cttccacttt tacttttcgt ccaaataaaa tgcatggtgt accagaagtt   3360

gaagatcggg ttgaggattg gggctagctc gatgacacta aggccccaac atcgcgggac   3420

ctgctgtggc gcggattctt aggaacgctg ttctagccgg ccccctctcc aggggtcgcc   3480

gtggccggca ttatttccta gttcttcttg taaccctgag gtgccagcgc ggggagtgag   3540

gaggggtcag ggggctaagg atgcaacctc tgacgttctg cgccttccta ggagagtctt   3600

acatgtgttg agatttcaca agcaatgcga gttgtaaaat accagctcta caagaagcta   3660

ggctctgtga cggcatagtt ttcagtagct ttatcacaat attcacaatg gagaattata   3720

tgacatggta gcagaaatag gcccttttat gtgttgcttc tattttacct caaattgtag   3780

atatagggta atcaataaaa tccatccatg cctttcacac actaagt                 3827


<210>  4579
<211>  937
<212>  PRT
<213>  Homo sapiens

<400>  4579

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
            500                 505                 510


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
        515                 520                 525


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
    530                 535                 540


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
545                 550                 555                 560


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
                565                 570                 575


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
            580                 585                 590


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
        595                 600                 605


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
    610                 615                 620


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
625                 630                 635                 640


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
                645                 650                 655


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
            660                 665                 670


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
        675                 680                 685


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
    690                 695                 700


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
705                 710                 715                 720


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
                725                 730                 735


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
            740                 745                 750


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
        755                 760                 765


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
    770                 775                 780


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
785                 790                 795                 800


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
                805                 810                 815


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
            820                 825                 830


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
        835                 840                 845


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
    850                 855                 860


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
865                 870                 875                 880


Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser 
                885                 890                 895


Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu 
            900                 905                 910


Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln 
        915                 920                 925


Ile Lys Gln Glu Pro Asp Pro Thr Trp 
    930                 935


<210>  4580
<211>  5170
<212>  DNA
<213>  Homo sapiens

<400>  4580
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   2040

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2100

taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2160

ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2220

ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2280

ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2340

ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2400

atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2460

agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2520

agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2580

tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2640

ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2700

tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2760

ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2820

atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2880

ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2940

tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   3000

ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   3060

tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3120

ttatcaaatt cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg   3180

atcagagtga gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag   3240

ttccagccac agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag   3300

accccacgtg gtagacctct tccctcctag ggtaaatcag cttctgtgtc agggatgctg   3360

tgtggtgtcc atctgaaccc cctgcatacg cgtagctaat gtgatctccc cactttcaca   3420

taagatggtg gccctgcctt cagggaatgt gggagccagg tgggagcctt cccggatatt   3480

taagctagaa gattctacag ggagattctc cttggatcaa tatatgtctc tcagtcaaag   3540

atgtaaaagc acttttgcct taaaaagaat gttctgtttc taaatagagt caacgttgtc   3600

ctcctcattg gaattcacta tgagtcagaa tcattagact gacttttttt tttccatagt   3660

aatagtattt tgcagagtct cacagagctg cagatctttt gttcatcttg cagagttaac   3720

aagtctgatc ctgttagtcc agatttctta aatttggcca agttataata ggagcagtag   3780

cttgagaccc gaagtcagga aactttgaca atggattttt ttttttaatc cagagacttg   3840

tactggaatt tgccttaccc tgtcagctca tggacttaag gtttcatccc gctttatgag   3900

tgcttctgaa tccaagtcat tgttacctga atttgcaaat taagttgtga tattcgtgac   3960

tgttaaattc ctgtaattag attaacctct ttgcttgctt gtttgttttc tctcctattt   4020

tagcttaaag tatcagtggt tgagaagagc ttttcggacc tgttactacc ccaagctgtg   4080

taatatactt gtataacaga aataccttct atacaaacct ttttttctac ttttagatag   4140

aaatgtctac tttttcagca gttctgtgaa ttaaagagca gagtgactgt gggtctggaa   4200

tggctggtgt acttgggaat gtactatcag gattttacag caatgctggg aaatgacagg   4260

gaaaatgaca ggaatgaatc tcaccagatt ttttatgtac tcagcagagc cttgagttac   4320

ggtgtttatt ttccaatcaa gtgaagatat ctcctacttc tcctactgga acatctcagc   4380

ttctgcagtg aagaaaaatt cctgtgatag ttcagttctt tagtttttct atttgaaaaa   4440

aaaaaatcat ttaaatgatc ctttgttcac ggctctcctt aatgactgag tgaacagttc   4500

ctatctgtat atttgactaa accttttcct aagctatctc tcatggttcc tatgtttttt   4560

tatcataatt aaaagcaaaa ccatctggat cacctaacag tcagaggtca gtatctcagc   4620

gtgtgaatta tagaggaaat acagagagaa cctcttccac ttttactttt cgtccaaata   4680

aaatgcatgg tgtaccagaa gttgaagatc gggttgagga ttggggctag ctcgatgaca   4740

ctaaggcccc aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg ctgttctagc   4800

cggccccctc tccaggggtc gccgtggccg gcattatttc ctagttcttc ttgtaaccct   4860

gaggtgccag cgcggggagt gaggaggggt cagggggcta aggatgcaac ctctgacgtt   4920

ctgcgccttc ctaggagagt cttacatgtg ttgagatttc acaagcaatg cgagttgtaa   4980

aataccagct ctacaagaag ctaggctctg tgacggcata gttttcagta gctttatcac   5040

aatattcaca atggagaatt atatgacatg gtagcagaaa taggcccttt tatgtgttgc   5100

ttctatttta cctcaaattg tagatatagg gtaatcaata aaatccatcc atgcctttca   5160

cacactaagt                                                          5170


<210>  4581
<211>  909
<212>  PRT
<213>  Homo sapiens

<400>  4581

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
465                 470                 475                 480


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
                485                 490                 495


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
            500                 505                 510


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
        515                 520                 525


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
    530                 535                 540


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
545                 550                 555                 560


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
                565                 570                 575


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
            580                 585                 590


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
        595                 600                 605


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
    610                 615                 620


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
625                 630                 635                 640


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
                645                 650                 655


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
            660                 665                 670


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
        675                 680                 685


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
    690                 695                 700


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
705                 710                 715                 720


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
                725                 730                 735


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
            740                 745                 750


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
        755                 760                 765


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
    770                 775                 780


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
785                 790                 795                 800


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
                805                 810                 815


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
            820                 825                 830


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
        835                 840                 845


Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu 
    850                 855                 860


Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu 
865                 870                 875                 880


Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp 
                885                 890                 895


Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
            900                 905


<210>  4582
<211>  5246
<212>  DNA
<213>  Homo sapiens

<400>  4582
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   1980

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gcttagattt   2040

gttgacagcg gtttcctgga gtgctgtctt gagaacgatt ctgaggaggc tcagcaagaa   2100

agagtgtttc agttgattgg gtgtgtctgt catggagaag gaactcaagc tcttggactc   2160

accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgtatgtg   2220

gaaggcttgc cagaggggat tcccttccga agccctacct ggtttggaat tccacgactt   2280

gaaaggatcg tccgcgggag taataaaatc aagttcgttg ttaaaaaacc tgaactagtt   2340

atttcctact tgcctcctgg gatggctagt aaaataaaca ctaaagcttt gcagtccccc   2400

aaaagaccac gaagtcctgg gagtaattca aaggttcctg aaattgaggt caccgtggaa   2460

ggccctaata acaacaatcc tcaaacctca gctgttcgaa ccccgaccca gactaacggt   2520

tctaacgttc ccttcaagcc acgagggaga gagttttcct ttgaggcctg gaatgccaaa   2580

atcacggacc taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg ggaagctctt   2640

ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg agtctttccc ggaagacttt   2700

tatgtggaag gcttacctga gggtgtgcca ttccgaagac catcgacttt tggcattccg   2760

aggctggaga agatactcag aaacaaagcc aaaattaagt tcatcattaa aaagcccgaa   2820

atgtttgaga cggcgattaa ggagagcacc tcctctaaga gccctcccag aaaaataaat   2880

tcatcaccca atgttaatac tactgcatca ggtgttgaag accttaacat cattcaggtg   2940

acaattccag atgatgataa tgaaagactc tcgaaagttg aaaaagctag acagctaaga   3000

gaacaagtga atgacctctt tagtcggaaa tttggtgaag ctattggtat gggttttcct   3060

gtgaaagttc cctacaggaa aatcacaatt aaccctggct gtgtggtggt tgatggcatg   3120

cccccggggg tgtccttcaa agcccccagc tacctggaaa tcagctccat gagaaggatc   3180

ttagactctg ccgagtttat caaattcacg gtcattagac catttccagg acttgtgatt   3240

aataaccagc tggttgatca gagtgagtca gaaggccccg tgatacaaga atcagctgaa   3300

ccaagccagt tggaagttcc agccacagaa gaaataaaag agactgatgg aagctctcag   3360

atcaagcaag aaccagaccc cacgtggtag acctcttccc tcctagggta aatcagcttc   3420

tgtgtcaggg atgctgtgtg gtgtccatct gaaccccctg catacgcgta gctaatgtga   3480

tctccccact ttcacataag atggtggccc tgccttcagg gaatgtggga gccaggtggg   3540

agccttcccg gatatttaag ctagaagatt ctacagggag attctccttg gatcaatata   3600

tgtctctcag tcaaagatgt aaaagcactt ttgccttaaa aagaatgttc tgtttctaaa   3660

tagagtcaac gttgtcctcc tcattggaat tcactatgag tcagaatcat tagactgact   3720

tttttttttc catagtaata gtattttgca gagtctcaca gagctgcaga tcttttgttc   3780

atcttgcaga gttaacaagt ctgatcctgt tagtccagat ttcttaaatt tggccaagtt   3840

ataataggag cagtagcttg agacccgaag tcaggaaact ttgacaatgg attttttttt   3900

ttaatccaga gacttgtact ggaatttgcc ttaccctgtc agctcatgga cttaaggttt   3960

catcccgctt tatgagtgct tctgaatcca agtcattgtt acctgaattt gcaaattaag   4020

ttgtgatatt cgtgactgtt aaattcctgt aattagatta acctctttgc ttgcttgttt   4080

gttttctctc ctattttagc ttaaagtatc agtggttgag aagagctttt cggacctgtt   4140

actaccccaa gctgtgtaat atacttgtat aacagaaata ccttctatac aaaccttttt   4200

ttctactttt agatagaaat gtctactttt tcagcagttc tgtgaattaa agagcagagt   4260

gactgtgggt ctggaatggc tggtgtactt gggaatgtac tatcaggatt ttacagcaat   4320

gctgggaaat gacagggaaa atgacaggaa tgaatctcac cagatttttt atgtactcag   4380

cagagccttg agttacggtg tttattttcc aatcaagtga agatatctcc tacttctcct   4440

actggaacat ctcagcttct gcagtgaaga aaaattcctg tgatagttca gttctttagt   4500

ttttctattt gaaaaaaaaa aatcatttaa atgatccttt gttcacggct ctccttaatg   4560

actgagtgaa cagttcctat ctgtatattt gactaaacct tttcctaagc tatctctcat   4620

ggttcctatg tttttttatc ataattaaaa gcaaaaccat ctggatcacc taacagtcag   4680

aggtcagtat ctcagcgtgt gaattataga ggaaatacag agagaacctc ttccactttt   4740

acttttcgtc caaataaaat gcatggtgta ccagaagttg aagatcgggt tgaggattgg   4800

ggctagctcg atgacactaa ggccccaaca tcgcgggacc tgctgtggcg cggattctta   4860

ggaacgctgt tctagccggc cccctctcca ggggtcgccg tggccggcat tatttcctag   4920

ttcttcttgt aaccctgagg tgccagcgcg gggagtgagg aggggtcagg gggctaagga   4980

tgcaacctct gacgttctgc gccttcctag gagagtctta catgtgttga gatttcacaa   5040

gcaatgcgag ttgtaaaata ccagctctac aagaagctag gctctgtgac ggcatagttt   5100

tcagtagctt tatcacaata ttcacaatgg agaattatat gacatggtag cagaaatagg   5160

cccttttatg tgttgcttct attttacctc aaattgtaga tatagggtaa tcaataaaat   5220

ccatccatgc ctttcacaca ctaagt                                        5246


<210>  4583
<211>  544
<212>  PRT
<213>  Homo sapiens

<400>  4583

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile 
        515                 520                 525


Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  4584
<211>  7191
<212>  DNA
<213>  Homo sapiens

<400>  4584
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagc tcaagctctt ggactcaccg   2040

aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag   2100

gcttgccaga ggggattccc ttccgaagcc ctacctggtt tggaattcca cgacttgaaa   2160

ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt   2220

cctacttgcc tcctgggatg gctagtaaaa taaacactaa agctttgcag tcccccaaaa   2280

gaccacgaag tcctgggagt aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc   2340

ctaataacaa caatcctcaa acctcagctg ttcgaacccc gacccagact aacggttcta   2400

acgttccctt caagccacga gggagagagt tttcctttga ggcctggaat gccaaaatca   2460

cggacctaaa acagaaagtt gaaaatctct tcaatgagaa atgtggggaa gctcttggcc   2520

ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc tttcccggaa gacttttatg   2580

tggaaggctt acctgagggt gtgccattcc gaagaccatc gacttttggc attccgaggc   2640

tggagaagat actcagaaac aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt   2700

ttgagacggc gattaaggag agcacctcct ctaagagccc tcccagaaaa ataaattcat   2760

cacccaatgt taatactact gcatcaggtg ttgaagacct taacatcatt caggtgacaa   2820

ttccagatga tgataatgaa agactctcga aagttgaaaa agctagacag ctaagagaac   2880

aagtgaatga cctctttagt cggaaatttg gtgaagctat tggtatgggt tttcctgtga   2940

aagttcccta caggaaaatc acaattaacc ctggctgtgt ggtggttgat ggcatgcccc   3000

cgggggtgtc cttcaaagcc cccagctacc tggaaatcag ctccatgaga aggatcttag   3060

actctgccga gtttatcaaa ttcacggtca ttaggtaagt gagagtttcc tgcttagtca   3120

caggagcgaa tctggagctc atgaggctga ctcttctaaa atgcagccac aggtagtcat   3180

cgaatccggc ttcctatgct gtgcaatcaa caaatcaaaa taacttgtgt catcattaga   3240

atgtcagatg tgcttctacg aactaagctg actcttttaa ttctttggca aagggttggc   3300

aaactaggac tgtttgccaa attcaggctg cctcctattt ttagagtctt cctgaaacac   3360

agctacaccc gtattatcca tggctgcttt cctgtcacag tgagtaagta gctgggactg   3420

agaaggcatg gcctccaaag tctaaaatat ttactctcta gcactttgta gaaaaacctt   3480

agctaggcac agtggctaac gcctgtaatc ccagcatttt gggaggccaa ggcaggcaga   3540

tcacctgagg tcaggagttc cagaccagcc tggccaacat ggtgaaatcc catctctaca   3600

aaaataaaac agttagctgg gcatgatggc gggtgcctgt aatcccagct actcgggagg   3660

ctgaggcagg atagtcgctt gaacccagga ggtggaggtt gcaatgagcc aagatcatgc   3720

cactgcactc cagcctggac gacagagtga gactccatca caagaaaaaa agaactttgt   3780

caacctctgt cttagggcgc cttgtcacag gcttcgggtc agacggattc aaccttgcat   3840

cagccatttg ttagccaggt cactctgttc tttgtctgta aatgagattg atcgttgttc   3900

ccactgagag tgtcagctcc ttcccgtaga gcaggcatga tgattgtact cacctctgac   3960

accattgtga gtgccacatt ccttcccacg tccttgtcac tgtaagagat gcccacctga   4020

gcaccaaccc caggttatct tcccctttgt cttccagccc cccagaaaca gctacgactc   4080

aacctaccca atcatttcat catcagattg ccactgtctc tagttcaggt ctcttgggac   4140

tggcactcag aaatctcata ataaatcctc ttgaggcttc tcatacactc gtcttcttcc   4200

aatcttcttt ccctcaaaat ctcatatttt ggttccactt cacccaccgt cattctccat   4260

atcactccca ggagttaggc aaaaagcccc ttccgttctt ccgtatgtta aacttagaat   4320

cactctgttc cctgctctgc gtttctattt tttgtttttc ctccatttac tagtagctta   4380

acactttcta acagtgttct tattattgat acgtatctat ctcttccata agcttataag   4440

gtcacggata atacttctca ttgtagtacg taaatgacgt gggctagata tgagttgaat   4500

aaacagttat acctgtaaat tcttacagag tgaaaataaa ttgttatact ttacaatttg   4560

tttctctctt tagaccattt ccaggacttg tgattaataa ccgtgagtat tttgtgaagt   4620

gttttgtttt tgttttttcc tggggtctga cgtgtgtgcg tgtgagtgtg tatacatgct   4680

taacgtatat cacgttactt cacctatgtc agtaaccagg ccaaatactt gttttagccc   4740

tcagtaaaaa caccaggcac ttcctagttg taaaattatt caagcttctt aacttcctat   4800

cctcgatgca cttaatcata aaatggtaat aatagcaccg attttggggg agtcgttcca   4860

gtagatggaa agcatctgga acaggtgtca gcaagctcct gccgacgtgt atgcataaag   4920

ttttattgaa accaccatcg tgtccatttg tttatggcag aactgagaga tggcagcagc   4980

aagtgtgtgc ctgcaaaacc taaaatattt actaattggc tctgcaagaa aagagtttgc   5040

atccccctaa cctagaacag tgtctagcct ctagtatgtg tttagcctac agtatgtgct   5100

cagcgaatac aatctatatt tattactgct tttatgactg ttataattac tgtgcttgga   5160

tttcgttaca aagtaagtca caatgtgcct gcttctgtta gtatttcagc acagtgcctg   5220

gcacacatgg ggctctcaaa tattgctgag cgagtgaaca aatgtccttt caattcctta   5280

acgttgatgt cattttcaat agtattttga gccaaactta attttgcgag tgtgttttgt   5340

tttcttaact ttattattaa aaatgtataa aagtgaggcc aggcgtggtg gctcacgcct   5400

gtaatcccag cagtttggga ggctgaggca ggcggatcag ttgaggttgg gagttggaga   5460

ccagcccgtc caacatggtg aaagcctgtc tctactaaaa atacaaaaat cagctgggtg   5520

tggtggcgcg tgcctgtaat cccagctact caggaggctg aggcaggaga gttgcttgaa   5580

tcctagaggt ggaggttgca gtgagctgag atcgtgccat tgcactccag cctgggcaac   5640

aagagcaaaa ctctgtccca ataaataaat aaataaaatg ttctcttttg ttcctgttct   5700

tgtgcggtag tgtggtatag agttttatgg taattactgt gaattagtga ttctgaggga   5760

catatcagaa ctctgaggtt tgtttccttc tcatcttgag ggaaacagca aatgtatgtt   5820

aaaatgcttt tccaagggaa caacacatcc ttacattatt taaaccaatc tgcttcattt   5880

tcagagctgg ttgatcagag tgagtcagaa ggccccgtga tacaagaatc agctgaacca   5940

agccagttgg aagttccagc cacagaagaa ataaaagaga ctgatggaag ctctcagatc   6000

aagcaagaac cagaccccac gtggtagacc tcttccctcc taggcttaaa gtatcagtgg   6060

ttgagaagag cttttcggac ctgttactac cccaagctgt gtaatatact tgtataacag   6120

aaataccttc tatacaaacc tttttttcta cttttagata gaaatgtcta ctttttcagc   6180

agttctgtga attaaagagc agagtgactg tgggtctgga atggctggtg tacttgggaa   6240

tgtactatca ggattttaca gcaatgctgg gaaatgacag ggaaaatgac aggaatgaat   6300

ctcaccagat tttttatgta ctcagcagag ccttgagtta cggtgtttat tttccaatca   6360

agtgaagata tctcctactt ctcctactgg aacatctcag cttctgcagt gaagaaaaat   6420

tcctgtgata gttcagttct ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat   6480

cctttgttca cggctctcct taatgactga gtgaacagtt cctatctgta tatttgacta   6540

aaccttttcc taagctatct ctcatggttc ctatgttttt ttatcataat taaaagcaaa   6600

accatctgga tcacctaaca gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa   6660

tacagagaga acctcttcca cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga   6720

agttgaagat cgggttgagg attggggcta gctcgatgac actaaggccc caacatcgcg   6780

ggacctgctg tggcgcggat tcttaggaac gctgttctag ccggccccct ctccaggggt   6840

cgccgtggcc ggcattattt cctagttctt cttgtaaccc tgaggtgcca gcgcggggag   6900

tgaggagggg tcagggggct aaggatgcaa cctctgacgt tctgcgcctt cctaggagag   6960

tcttacatgt gttgagattt cacaagcaat gcgagttgta aaataccagc tctacaagaa   7020

gctaggctct gtgacggcat agttttcagt agctttatca caatattcac aatggagaat   7080

tatatgacat ggtagcagaa ataggccctt ttatgtgttg cttctatttt acctcaaatt   7140

gtagatatag ggtaatcaat aaaatccatc catgcctttc acacactaag t            7191


<210>  4585
<211>  898
<212>  PRT
<213>  Homo sapiens

<400>  4585

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly 
    530                 535                 540


Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro 
545                 550                 555                 560


Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser 
                565                 570                 575


Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser 
            580                 585                 590


Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr 
        595                 600                 605


Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser 
    610                 615                 620


Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile 
625                 630                 635                 640


Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala 
                645                 650                 655


Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro 
            660                 665                 670


Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp 
        675                 680                 685


Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala 
    690                 695                 700


Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser 
705                 710                 715                 720


Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe 
                725                 730                 735


Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg 
            740                 745                 750


Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu 
        755                 760                 765


Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile 
    770                 775                 780


Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu 
785                 790                 795                 800


Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser 
                805                 810                 815


Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe 
            820                 825                 830


Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val 
        835                 840                 845


Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly 
    850                 855                 860


Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser 
865                 870                 875                 880


Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val 
                885                 890                 895


Ile Arg 



<210>  4586
<211>  7883
<212>  DNA
<213>  Homo sapiens

<400>  4586
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagc tcaagctctt ggactcaccg   2040

aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag   2100

gcttgccaga ggggattccc ttccgaagcc ctacctggtt tggaattcca cgacttgaaa   2160

ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt   2220

cctacttgcc tcctgggatg gctagtaaaa taaacactaa agctttgcag tcccccaaaa   2280

gaccacgaag tcctgggagt aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc   2340

ctaataacaa caatcctcaa acctcagctg ttcgaacccc gacccagact aacggttcta   2400

acgttccctt caagccacga gggagagagt tttcctttga ggcctggaat gccaaaatca   2460

cggacctaaa acagaaagtt gaaaatctct tcaatgagaa atgtggggaa gctcttggcc   2520

ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc tttcccggaa gacttttatg   2580

tggaaggctt acctgagggt gtgccattcc gaagaccatc gacttttggc attccgaggc   2640

tggagaagat actcagaaac aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt   2700

ttgagacggc gattaaggag agcacctcct ctaagagccc tcccagaaaa ataaattcat   2760

cacccaatgt taatactact gcatcaggtg ttgaagacct taacatcatt caggtgacaa   2820

ttccagatga tgataatgaa agactctcga aagttgaaaa agctagacag ctaagagaac   2880

aagtgaatga cctctttagt cggaaatttg gtgaagctat tggtatgggt tttcctgtga   2940

aagttcccta caggaaaatc acaattaacc ctggctgtgt ggtggttgat ggcatgcccc   3000

cgggggtgtc cttcaaagcc cccagctacc tggaaatcag ctccatgaga aggatcttag   3060

actctgccga gtttatcaaa ttcacggtca ttaggtaagt gagagtttcc tgcttagtca   3120

caggagcgaa tctggagctc atgaggctga ctcttctaaa atgcagccac aggtagtcat   3180

cgaatccggc ttcctatgct gtgcaatcaa caaatcaaaa taacttgtgt catcattaga   3240

atgtcagatg tgcttctacg aactaagctg actcttttaa ttctttggca aagggttggc   3300

aaactaggac tgtttgccaa attcaggctg cctcctattt ttagagtctt cctgaaacac   3360

agctacaccc gtattatcca tggctgcttt cctgtcacag tgagtaagta gctgggactg   3420

agaaggcatg gcctccaaag tctaaaatat ttactctcta gcactttgta gaaaaacctt   3480

agctaggcac agtggctaac gcctgtaatc ccagcatttt gggaggccaa ggcaggcaga   3540

tcacctgagg tcaggagttc cagaccagcc tggccaacat ggtgaaatcc catctctaca   3600

aaaataaaac agttagctgg gcatgatggc gggtgcctgt aatcccagct actcgggagg   3660

ctgaggcagg atagtcgctt gaacccagga ggtggaggtt gcaatgagcc aagatcatgc   3720

cactgcactc cagcctggac gacagagtga gactccatca caagaaaaaa agaactttgt   3780

caacctctgt cttagggcgc cttgtcacag gcttcgggtc agacggattc aaccttgcat   3840

cagccatttg ttagccaggt cactctgttc tttgtctgta aatgagattg atcgttgttc   3900

ccactgagag tgtcagctcc ttcccgtaga gcaggcatga tgattgtact cacctctgac   3960

accattgtga gtgccacatt ccttcccacg tccttgtcac tgtaagagat gcccacctga   4020

gcaccaaccc caggttatct tcccctttgt cttccagccc cccagaaaca gctacgactc   4080

aacctaccca atcatttcat catcagattg ccactgtctc tagttcaggt ctcttgggac   4140

tggcactcag aaatctcata ataaatcctc ttgaggcttc tcatacactc gtcttcttcc   4200

aatcttcttt ccctcaaaat ctcatatttt ggttccactt cacccaccgt cattctccat   4260

atcactccca ggagttaggc aaaaagcccc ttccgttctt ccgtatgtta aacttagaat   4320

cactctgttc cctgctctgc gtttctattt tttgtttttc ctccatttac tagtagctta   4380

acactttcta acagtgttct tattattgat acgtatctat ctcttccata agcttataag   4440

gtcacggata atacttctca ttgtagtacg taaatgacgt gggctagata tgagttgaat   4500

aaacagttat acctgtaaat tcttacagag tgaaaataaa ttgttatact ttacaatttg   4560

tttctctctt tagaccattt ccaggacttg tgattaataa ccgtgagtat tttgtgaagt   4620

gttttgtttt tgttttttcc tggggtctga cgtgtgtgcg tgtgagtgtg tatacatgct   4680

taacgtatat cacgttactt cacctatgtc agtaaccagg ccaaatactt gttttagccc   4740

tcagtaaaaa caccaggcac ttcctagttg taaaattatt caagcttctt aacttcctat   4800

cctcgatgca cttaatcata aaatggtaat aatagcaccg attttggggg agtcgttcca   4860

gtagatggaa agcatctgga acaggtgtca gcaagctcct gccgacgtgt atgcataaag   4920

ttttattgaa accaccatcg tgtccatttg tttatggcag aactgagaga tggcagcagc   4980

aagtgtgtgc ctgcaaaacc taaaatattt actaattggc tctgcaagaa aagagtttgc   5040

atccccctaa cctagaacag tgtctagcct ctagtatgtg tttagcctac agtatgtgct   5100

cagcgaatac aatctatatt tattactgct tttatgactg ttataattac tgtgcttgga   5160

tttcgttaca aagtaagtca caatgtgcct gcttctgtta gtatttcagc acagtgcctg   5220

gcacacatgg ggctctcaaa tattgctgag cgagtgaaca aatgtccttt caattcctta   5280

acgttgatgt cattttcaat agtattttga gccaaactta attttgcgag tgtgttttgt   5340

tttcttaact ttattattaa aaatgtataa aagtgaggcc aggcgtggtg gctcacgcct   5400

gtaatcccag cagtttggga ggctgaggca ggcggatcag ttgaggttgg gagttggaga   5460

ccagcccgtc caacatggtg aaagcctgtc tctactaaaa atacaaaaat cagctgggtg   5520

tggtggcgcg tgcctgtaat cccagctact caggaggctg aggcaggaga gttgcttgaa   5580

tcctagaggt ggaggttgca gtgagctgag atcgtgccat tgcactccag cctgggcaac   5640

aagagcaaaa ctctgtccca ataaataaat aaataaaatg ttctcttttg ttcctgttct   5700

tgtgcggtag tgtggtatag agttttatgg taattactgt gaattagtga ttctgaggga   5760

catatcagaa ctctgaggtt tgtttccttc tcatcttgag ggaaacagca aatgtatgtt   5820

aaaatgcttt tccaagggaa caacacatcc ttacattatt taaaccaatc tgcttcattt   5880

tcagagctgg ttgatcagag tgagtcagaa ggccccgtga tacaagaatc agctgaacca   5940

agccagttgg aagttccagc cacagaagaa ataaaagaga ctgatggaag ctctcagatc   6000

aagcaagaac cagaccccac gtggtagacc tcttccctcc tagggtaaat cagcttctgt   6060

gtcagggatg ctgtgtggtg tccatctgaa ccccctgcat acgcgtagct aatgtgatct   6120

ccccactttc acataagatg gtggccctgc cttcagggaa tgtgggagcc aggtgggagc   6180

cttcccggat atttaagcta gaagattcta cagggagatt ctccttggat caatatatgt   6240

ctctcagtca aagatgtaaa agcacttttg ccttaaaaag aatgttctgt ttctaaatag   6300

agtcaacgtt gtcctcctca ttggaattca ctatgagtca gaatcattag actgactttt   6360

ttttttccat agtaatagta ttttgcagag tctcacagag ctgcagatct tttgttcatc   6420

ttgcagagtt aacaagtctg atcctgttag tccagatttc ttaaatttgg ccaagttata   6480

ataggagcag tagcttgaga cccgaagtca ggaaactttg acaatggatt ttttttttta   6540

atccagagac ttgtactgga atttgcctta ccctgtcagc tcatggactt aaggtttcat   6600

cccgctttat gagtgcttct gaatccaagt cattgttacc tgaatttgca aattaagttg   6660

tgatattcgt gactgttaaa ttcctgtaat tagattaacc tctttgcttg cttgtttgtt   6720

ttctctccta ttttagctta aagtatcagt ggttgagaag agcttttcgg acctgttact   6780

accccaagct gtgtaatata cttgtataac agaaatacct tctatacaaa cctttttttc   6840

tacttttaga tagaaatgtc tactttttca gcagttctgt gaattaaaga gcagagtgac   6900

tgtgggtctg gaatggctgg tgtacttggg aatgtactat caggatttta cagcaatgct   6960

gggaaatgac agggaaaatg acaggaatga atctcaccag attttttatg tactcagcag   7020

agccttgagt tacggtgttt attttccaat caagtgaaga tatctcctac ttctcctact   7080

ggaacatctc agcttctgca gtgaagaaaa attcctgtga tagttcagtt ctttagtttt   7140

tctatttgaa aaaaaaaaat catttaaatg atcctttgtt cacggctctc cttaatgact   7200

gagtgaacag ttcctatctg tatatttgac taaacctttt cctaagctat ctctcatggt   7260

tcctatgttt ttttatcata attaaaagca aaaccatctg gatcacctaa cagtcagagg   7320

tcagtatctc agcgtgtgaa ttatagagga aatacagaga gaacctcttc cacttttact   7380

tttcgtccaa ataaaatgca tggtgtacca gaagttgaag atcgggttga ggattggggc   7440

tagctcgatg acactaaggc cccaacatcg cgggacctgc tgtggcgcgg attcttagga   7500

acgctgttct agccggcccc ctctccaggg gtcgccgtgg ccggcattat ttcctagttc   7560

ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc   7620

aacctctgac gttctgcgcc ttcctaggag agtcttacat gtgttgagat ttcacaagca   7680

atgcgagttg taaaatacca gctctacaag aagctaggct ctgtgacggc atagttttca   7740

gtagctttat cacaatattc acaatggaga attatatgac atggtagcag aaataggccc   7800

ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat agggtaatca ataaaatcca   7860

tccatgcctt tcacacacta agt                                           7883


<210>  4587
<211>  898
<212>  PRT
<213>  Homo sapiens

<400>  4587

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly 
    530                 535                 540


Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro 
545                 550                 555                 560


Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser 
                565                 570                 575


Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser 
            580                 585                 590


Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr 
        595                 600                 605


Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser 
    610                 615                 620


Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile 
625                 630                 635                 640


Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala 
                645                 650                 655


Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro 
            660                 665                 670


Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp 
        675                 680                 685


Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala 
    690                 695                 700


Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser 
705                 710                 715                 720


Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe 
                725                 730                 735


Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg 
            740                 745                 750


Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu 
        755                 760                 765


Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile 
    770                 775                 780


Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu 
785                 790                 795                 800


Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser 
                805                 810                 815


Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe 
            820                 825                 830


Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val 
        835                 840                 845


Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly 
    850                 855                 860


Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser 
865                 870                 875                 880


Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val 
                885                 890                 895


Ile Arg 



<210>  4588
<211>  4211
<212>  DNA
<213>  Homo sapiens

<400>  4588
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1980

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   2040

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttgt   2100

atgtggaagg cttgccagag gggattccct tccgaagccc tacctggttt ggaattccac   2160

gacttgaaag gatcgtccgc gggagtaata aaatcaagtt cgttgttaaa aaacctgaac   2220

tagttatttc ctacttgcct cctgggatgg ctagtaaaat aaacactaaa gctttgcagt   2280

cccccaaaag accacgaagt cctgggagta attcaaaggt tcctgaaatt gaggtcaccg   2340

tggaaggccc taataacaac aatcctcaaa cctcagctgt tcgaaccccg acccagacta   2400

acggttctaa cgttcccttc aagccacgag ggagagagtt ttcctttgag gcctggaatg   2460

ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt caatgagaaa tgtggggaag   2520

ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt atttgagtct ttcccggaag   2580

acttttatgt ggaaggctta cctgagggtg tgccattccg aagaccatcg acttttggca   2640

ttccgaggct ggagaagata ctcagaaaca aagccaaaat taagttcatc attaaaaagc   2700

ccgaaatgtt tgagacggcg attaaggaga gcacctcctc taagagccct cccagaaaaa   2760

taaattcatc acccaatgtt aatactactg catcaggtgt tgaagacctt aacatcattc   2820

aggtgacaat tccagatgat gataatgaaa gactctcgaa agttgaaaaa gctagacagc   2880

taagagaaca agtgaatgac ctctttagtc ggaaatttgg tgaagctatt ggtatgggtt   2940

ttcctgtgaa agttccctac aggaaaatca caattaaccc tggctgtgtg gtggttgatg   3000

gcatgccccc gggggtgtcc ttcaaagccc ccagctacct ggaaatcagc tccatgagaa   3060

ggatcttaga ctctgccgag tttatcaaat tcacggtcat tagaccattt ccaggacttg   3120

tgattaataa ccagctggtt gatcagagtg agtcagaagg ccccgtgata caagaatcag   3180

ctgaaccaag ccagttggaa gttccagcca cagaagaaat aaaagagact gatggaagct   3240

ctcagatcaa gcaagaacca gaccccacgt ggtagacctc ttccctccta ggcttaaagt   3300

atcagtggtt gagaagagct tttcggacct gttactaccc caagctgtag ccttgagtta   3360

cggtgtttat tttccaatca agtgaagata tctcctactt ctcctactgg aacatctcag   3420

cttctgcagt gaagaaaaat tcctgtgata gttcagttct ttagtttttc tatttgaaaa   3480

aaaaaaatca tttaaatgat cctttgttca cggctctcct taatgactga gtgaacagtt   3540

cctatctgta tatttgacta aaccttttcc taagctatct ctcatggttc ctatgttttt   3600

ttatcataat taaaagcaaa accatctgga tcacctaaca gtcagaggtc agtatctcag   3660

cgtgtgaatt atagaggaaa tacagagaga acctcttcca cttttacttt tcgtccaaat   3720

aaaatgcatg gtgtaccaga agttgaagat cgggttgagg attggggcta gctcgatgac   3780

actaaggccc caacatcgcg ggacctgctg tggcgcggat tcttaggaac gctgttctag   3840

ccggccccct ctccaggggt cgccgtggcc ggcattattt cctagttctt cttgtaaccc   3900

tgaggtgcca gcgcggggag tgaggagggg tcagggggct aaggatgcaa cctctgacgt   3960

tctgcgcctt cctaggagag tcttacatgt gttgagattt cacaagcaat gcgagttgta   4020

aaataccagc tctacaagaa gctaggctct gtgacggcat agttttcagt agctttatca   4080

caatattcac aatggagaat tatatgacat ggtagcagaa ataggccctt ttatgtgttg   4140

cttctatttt acctcaaatt gtagatatag ggtaatcaat aaaatccatc catgcctttc   4200

acacactaag t                                                        4211


<210>  4589
<211>  957
<212>  PRT
<213>  Homo sapiens

<400>  4589

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
                565                 570                 575


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
            580                 585                 590


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
        595                 600                 605


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
    610                 615                 620


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
625                 630                 635                 640


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
                645                 650                 655


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
            660                 665                 670


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
        675                 680                 685


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
    690                 695                 700


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
705                 710                 715                 720


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
                725                 730                 735


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
            740                 745                 750


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
        755                 760                 765


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
    770                 775                 780


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
785                 790                 795                 800


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
                805                 810                 815


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
            820                 825                 830


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
        835                 840                 845


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
    850                 855                 860


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
865                 870                 875                 880


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
                885                 890                 895


Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu 
            900                 905                 910


Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu 
        915                 920                 925


Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp 
    930                 935                 940


Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950                 955


<210>  4590
<211>  7140
<212>  DNA
<213>  Homo sapiens

<400>  4590
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1920

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   1980

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttgt   2040

atgtggaagg cttgccagag gggattccct tccgaagccc tacctggttt ggaattccac   2100

gacttgaaag gatcgtccgc gggagtaata aaatcaagtt cgttgttaaa aaacctgaac   2160

tagttatttc ctacttgcct cctgggatgg ctagtaaaat aaacactaaa gctttgcagt   2220

cccccaaaag accacgaagt cctgggagta attcaaaggt tcctgaaatt gaggtcaccg   2280

tggaaggccc taataacaac aatcctcaaa cctcagctgt tcgaaccccg acccagacta   2340

acggttctaa cgttcccttc aagccacgag ggagagagtt ttcctttgag gcctggaatg   2400

ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt caatgagaaa tgtggggaag   2460

ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt atttgagtct ttcccggaag   2520

acttttatgt ggaaggctta cctgagggtg tgccattccg aagaccatcg acttttggca   2580

ttccgaggct ggagaagata ctcagaaaca aagccaaaat taagttcatc attaaaaagc   2640

ccgaaatgtt tgagacggcg attaaggaga gcacctcctc taagagccct cccagaaaaa   2700

taaattcatc acccaatgtt aatactactg catcaggtgt tgaagacctt aacatcattc   2760

aggtgacaat tccagatgat gataatgaaa gactctcgaa agttgaaaaa gctagacagc   2820

taagagaaca agtgaatgac ctctttagtc ggaaatttgg tgaagctatt ggtatgggtt   2880

ttcctgtgaa agttccctac aggaaaatca caattaaccc tggctgtgtg gtggttgatg   2940

gcatgccccc gggggtgtcc ttcaaagccc ccagctacct ggaaatcagc tccatgagaa   3000

ggatcttaga ctctgccgag tttatcaaat tcacggtcat taggtaagtg agagtttcct   3060

gcttagtcac aggagcgaat ctggagctca tgaggctgac tcttctaaaa tgcagccaca   3120

ggtagtcatc gaatccggct tcctatgctg tgcaatcaac aaatcaaaat aacttgtgtc   3180

atcattagaa tgtcagatgt gcttctacga actaagctga ctcttttaat tctttggcaa   3240

agggttggca aactaggact gtttgccaaa ttcaggctgc ctcctatttt tagagtcttc   3300

ctgaaacaca gctacacccg tattatccat ggctgctttc ctgtcacagt gagtaagtag   3360

ctgggactga gaaggcatgg cctccaaagt ctaaaatatt tactctctag cactttgtag   3420

aaaaacctta gctaggcaca gtggctaacg cctgtaatcc cagcattttg ggaggccaag   3480

gcaggcagat cacctgaggt caggagttcc agaccagcct ggccaacatg gtgaaatccc   3540

atctctacaa aaataaaaca gttagctggg catgatggcg ggtgcctgta atcccagcta   3600

ctcgggaggc tgaggcagga tagtcgcttg aacccaggag gtggaggttg caatgagcca   3660

agatcatgcc actgcactcc agcctggacg acagagtgag actccatcac aagaaaaaaa   3720

gaactttgtc aacctctgtc ttagggcgcc ttgtcacagg cttcgggtca gacggattca   3780

accttgcatc agccatttgt tagccaggtc actctgttct ttgtctgtaa atgagattga   3840

tcgttgttcc cactgagagt gtcagctcct tcccgtagag caggcatgat gattgtactc   3900

acctctgaca ccattgtgag tgccacattc cttcccacgt ccttgtcact gtaagagatg   3960

cccacctgag caccaacccc aggttatctt cccctttgtc ttccagcccc ccagaaacag   4020

ctacgactca acctacccaa tcatttcatc atcagattgc cactgtctct agttcaggtc   4080

tcttgggact ggcactcaga aatctcataa taaatcctct tgaggcttct catacactcg   4140

tcttcttcca atcttctttc cctcaaaatc tcatattttg gttccacttc acccaccgtc   4200

attctccata tcactcccag gagttaggca aaaagcccct tccgttcttc cgtatgttaa   4260

acttagaatc actctgttcc ctgctctgcg tttctatttt ttgtttttcc tccatttact   4320

agtagcttaa cactttctaa cagtgttctt attattgata cgtatctatc tcttccataa   4380

gcttataagg tcacggataa tacttctcat tgtagtacgt aaatgacgtg ggctagatat   4440

gagttgaata aacagttata cctgtaaatt cttacagagt gaaaataaat tgttatactt   4500

tacaatttgt ttctctcttt agaccatttc caggacttgt gattaataac cgtgagtatt   4560

ttgtgaagtg ttttgttttt gttttttcct ggggtctgac gtgtgtgcgt gtgagtgtgt   4620

atacatgctt aacgtatatc acgttacttc acctatgtca gtaaccaggc caaatacttg   4680

ttttagccct cagtaaaaac accaggcact tcctagttgt aaaattattc aagcttctta   4740

acttcctatc ctcgatgcac ttaatcataa aatggtaata atagcaccga ttttggggga   4800

gtcgttccag tagatggaaa gcatctggaa caggtgtcag caagctcctg ccgacgtgta   4860

tgcataaagt tttattgaaa ccaccatcgt gtccatttgt ttatggcaga actgagagat   4920

ggcagcagca agtgtgtgcc tgcaaaacct aaaatattta ctaattggct ctgcaagaaa   4980

agagtttgca tccccctaac ctagaacagt gtctagcctc tagtatgtgt ttagcctaca   5040

gtatgtgctc agcgaataca atctatattt attactgctt ttatgactgt tataattact   5100

gtgcttggat ttcgttacaa agtaagtcac aatgtgcctg cttctgttag tatttcagca   5160

cagtgcctgg cacacatggg gctctcaaat attgctgagc gagtgaacaa atgtcctttc   5220

aattccttaa cgttgatgtc attttcaata gtattttgag ccaaacttaa ttttgcgagt   5280

gtgttttgtt ttcttaactt tattattaaa aatgtataaa agtgaggcca ggcgtggtgg   5340

ctcacgcctg taatcccagc agtttgggag gctgaggcag gcggatcagt tgaggttggg   5400

agttggagac cagcccgtcc aacatggtga aagcctgtct ctactaaaaa tacaaaaatc   5460

agctgggtgt ggtggcgcgt gcctgtaatc ccagctactc aggaggctga ggcaggagag   5520

ttgcttgaat cctagaggtg gaggttgcag tgagctgaga tcgtgccatt gcactccagc   5580

ctgggcaaca agagcaaaac tctgtcccaa taaataaata aataaaatgt tctcttttgt   5640

tcctgttctt gtgcggtagt gtggtataga gttttatggt aattactgtg aattagtgat   5700

tctgagggac atatcagaac tctgaggttt gtttccttct catcttgagg gaaacagcaa   5760

atgtatgtta aaatgctttt ccaagggaac aacacatcct tacattattt aaaccaatct   5820

gcttcatttt cagagctggt tgatcagagt gagtcagaag gccccgtgat acaagaatca   5880

gctgaaccaa gccagttgga agttccagcc acagaagaaa taaaagagac tgatggaagc   5940

tctcagatca agcaagaacc agaccccacg tggtagacct cttccctcct aggcttaaag   6000

tatcagtggt tgagaagagc ttttcggacc tgttactacc ccaagctgtg taatatactt   6060

gtataacaga aataccttct atacaaacct ttttttctac ttttagatag aaatgtctac   6120

tttttcagca gttctgtgaa ttaaagagca gagtgactgt gggtctggaa tggctggtgt   6180

acttgggaat gtactatcag gattttacag caatgctggg aaatgacagg gaaaatgaca   6240

ggaatgaatc tcaccagatt ttttatgtac tcagcagagc cttgagttac ggtgtttatt   6300

ttccaatcaa gtgaagatat ctcctacttc tcctactgga acatctcagc ttctgcagtg   6360

aagaaaaatt cctgtgatag ttcagttctt tagtttttct atttgaaaaa aaaaaatcat   6420

ttaaatgatc ctttgttcac ggctctcctt aatgactgag tgaacagttc ctatctgtat   6480

atttgactaa accttttcct aagctatctc tcatggttcc tatgtttttt tatcataatt   6540

aaaagcaaaa ccatctggat cacctaacag tcagaggtca gtatctcagc gtgtgaatta   6600

tagaggaaat acagagagaa cctcttccac ttttactttt cgtccaaata aaatgcatgg   6660

tgtaccagaa gttgaagatc gggttgagga ttggggctag ctcgatgaca ctaaggcccc   6720

aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg ctgttctagc cggccccctc   6780

tccaggggtc gccgtggccg gcattatttc ctagttcttc ttgtaaccct gaggtgccag   6840

cgcggggagt gaggaggggt cagggggcta aggatgcaac ctctgacgtt ctgcgccttc   6900

ctaggagagt cttacatgtg ttgagatttc acaagcaatg cgagttgtaa aataccagct   6960

ctacaagaag ctaggctctg tgacggcata gttttcagta gctttatcac aatattcaca   7020

atggagaatt atatgacatg gtagcagaaa taggcccttt tatgtgttgc ttctatttta   7080

cctcaaattg tagatatagg gtaatcaata aaatccatcc atgcctttca cacactaagt   7140


<210>  4591
<211>  881
<212>  PRT
<213>  Homo sapiens

<400>  4591

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
            500                 505                 510


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
        515                 520                 525


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
    530                 535                 540


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
545                 550                 555                 560


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
                565                 570                 575


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
            580                 585                 590


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
        595                 600                 605


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
    610                 615                 620


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
625                 630                 635                 640


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
                645                 650                 655


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
            660                 665                 670


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
        675                 680                 685


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
    690                 695                 700


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
705                 710                 715                 720


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
                725                 730                 735


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
            740                 745                 750


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
        755                 760                 765


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
    770                 775                 780


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
785                 790                 795                 800


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
                805                 810                 815


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
            820                 825                 830


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
        835                 840                 845


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
    850                 855                 860


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
865                 870                 875                 880


Arg 



<210>  4592
<211>  7828
<212>  DNA
<213>  Homo sapiens

<400>  4592
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   1980

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2040

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2100

tgaaaggatc gtccgcggga gtaataaaat caagttcgtt gttaaaaaac ctgaactagt   2160

tatttcctac ttgcctcctg ggatggctag taaaataaac actaaagctt tgcagtcccc   2220

caaaagacca cgaagtcctg ggagtaattc aaaggttcct gaaattgagg tcaccgtgga   2280

aggccctaat aacaacaatc ctcaaacctc agctgttcga accccgaccc agactaacgg   2340

ttctaacgtt cccttcaagc cacgagggag agagttttcc tttgaggcct ggaatgccaa   2400

aatcacggac ctaaaacaga aagttgaaaa tctcttcaat gagaaatgtg gggaagctct   2460

tggccttaaa caagctgtga aggtgccgtt cgcgttattt gagtctttcc cggaagactt   2520

ttatgtggaa ggcttacctg agggtgtgcc attccgaaga ccatcgactt ttggcattcc   2580

gaggctggag aagatactca gaaacaaagc caaaattaag ttcatcatta aaaagcccga   2640

aatgtttgag acggcgatta aggagagcac ctcctctaag agccctccca gaaaaataaa   2700

ttcatcaccc aatgttaata ctactgcatc aggtgttgaa gaccttaaca tcattcaggt   2760

gacaattcca gatgatgata atgaaagact ctcgaaagtt gaaaaagcta gacagctaag   2820

agaacaagtg aatgacctct ttagtcggaa atttggtgaa gctattggta tgggttttcc   2880

tgtgaaagtt ccctacagga aaatcacaat taaccctggc tgtgtggtgg ttgatggcat   2940

gcccccgggg gtgtccttca aagcccccag ctacctggaa atcagctcca tgagaaggat   3000

cttagactct gccgagttta tcaaattcac ggtcattagg taagtgagag tttcctgctt   3060

agtcacagga gcgaatctgg agctcatgag gctgactctt ctaaaatgca gccacaggta   3120

gtcatcgaat ccggcttcct atgctgtgca atcaacaaat caaaataact tgtgtcatca   3180

ttagaatgtc agatgtgctt ctacgaacta agctgactct tttaattctt tggcaaaggg   3240

ttggcaaact aggactgttt gccaaattca ggctgcctcc tatttttaga gtcttcctga   3300

aacacagcta cacccgtatt atccatggct gctttcctgt cacagtgagt aagtagctgg   3360

gactgagaag gcatggcctc caaagtctaa aatatttact ctctagcact ttgtagaaaa   3420

accttagcta ggcacagtgg ctaacgcctg taatcccagc attttgggag gccaaggcag   3480

gcagatcacc tgaggtcagg agttccagac cagcctggcc aacatggtga aatcccatct   3540

ctacaaaaat aaaacagtta gctgggcatg atggcgggtg cctgtaatcc cagctactcg   3600

ggaggctgag gcaggatagt cgcttgaacc caggaggtgg aggttgcaat gagccaagat   3660

catgccactg cactccagcc tggacgacag agtgagactc catcacaaga aaaaaagaac   3720

tttgtcaacc tctgtcttag ggcgccttgt cacaggcttc gggtcagacg gattcaacct   3780

tgcatcagcc atttgttagc caggtcactc tgttctttgt ctgtaaatga gattgatcgt   3840

tgttcccact gagagtgtca gctccttccc gtagagcagg catgatgatt gtactcacct   3900

ctgacaccat tgtgagtgcc acattccttc ccacgtcctt gtcactgtaa gagatgccca   3960

cctgagcacc aaccccaggt tatcttcccc tttgtcttcc agccccccag aaacagctac   4020

gactcaacct acccaatcat ttcatcatca gattgccact gtctctagtt caggtctctt   4080

gggactggca ctcagaaatc tcataataaa tcctcttgag gcttctcata cactcgtctt   4140

cttccaatct tctttccctc aaaatctcat attttggttc cacttcaccc accgtcattc   4200

tccatatcac tcccaggagt taggcaaaaa gccccttccg ttcttccgta tgttaaactt   4260

agaatcactc tgttccctgc tctgcgtttc tattttttgt ttttcctcca tttactagta   4320

gcttaacact ttctaacagt gttcttatta ttgatacgta tctatctctt ccataagctt   4380

ataaggtcac ggataatact tctcattgta gtacgtaaat gacgtgggct agatatgagt   4440

tgaataaaca gttatacctg taaattctta cagagtgaaa ataaattgtt atactttaca   4500

atttgtttct ctctttagac catttccagg acttgtgatt aataaccgtg agtattttgt   4560

gaagtgtttt gtttttgttt tttcctgggg tctgacgtgt gtgcgtgtga gtgtgtatac   4620

atgcttaacg tatatcacgt tacttcacct atgtcagtaa ccaggccaaa tacttgtttt   4680

agccctcagt aaaaacacca ggcacttcct agttgtaaaa ttattcaagc ttcttaactt   4740

cctatcctcg atgcacttaa tcataaaatg gtaataatag caccgatttt gggggagtcg   4800

ttccagtaga tggaaagcat ctggaacagg tgtcagcaag ctcctgccga cgtgtatgca   4860

taaagtttta ttgaaaccac catcgtgtcc atttgtttat ggcagaactg agagatggca   4920

gcagcaagtg tgtgcctgca aaacctaaaa tatttactaa ttggctctgc aagaaaagag   4980

tttgcatccc cctaacctag aacagtgtct agcctctagt atgtgtttag cctacagtat   5040

gtgctcagcg aatacaatct atatttatta ctgcttttat gactgttata attactgtgc   5100

ttggatttcg ttacaaagta agtcacaatg tgcctgcttc tgttagtatt tcagcacagt   5160

gcctggcaca catggggctc tcaaatattg ctgagcgagt gaacaaatgt cctttcaatt   5220

ccttaacgtt gatgtcattt tcaatagtat tttgagccaa acttaatttt gcgagtgtgt   5280

tttgttttct taactttatt attaaaaatg tataaaagtg aggccaggcg tggtggctca   5340

cgcctgtaat cccagcagtt tgggaggctg aggcaggcgg atcagttgag gttgggagtt   5400

ggagaccagc ccgtccaaca tggtgaaagc ctgtctctac taaaaataca aaaatcagct   5460

gggtgtggtg gcgcgtgcct gtaatcccag ctactcagga ggctgaggca ggagagttgc   5520

ttgaatccta gaggtggagg ttgcagtgag ctgagatcgt gccattgcac tccagcctgg   5580

gcaacaagag caaaactctg tcccaataaa taaataaata aaatgttctc ttttgttcct   5640

gttcttgtgc ggtagtgtgg tatagagttt tatggtaatt actgtgaatt agtgattctg   5700

agggacatat cagaactctg aggtttgttt ccttctcatc ttgagggaaa cagcaaatgt   5760

atgttaaaat gcttttccaa gggaacaaca catccttaca ttatttaaac caatctgctt   5820

cattttcaga gctggttgat cagagtgagt cagaaggccc cgtgatacaa gaatcagctg   5880

aaccaagcca gttggaagtt ccagccacag aagaaataaa agagactgat ggaagctctc   5940

agatcaagca agaaccagac cccacgtggt agacctcttc cctcctaggg taaatcagct   6000

tctgtgtcag ggatgctgtg tggtgtccat ctgaaccccc tgcatacgcg tagctaatgt   6060

gatctcccca ctttcacata agatggtggc cctgccttca gggaatgtgg gagccaggtg   6120

ggagccttcc cggatattta agctagaaga ttctacaggg agattctcct tggatcaata   6180

tatgtctctc agtcaaagat gtaaaagcac ttttgcctta aaaagaatgt tctgtttcta   6240

aatagagtca acgttgtcct cctcattgga attcactatg agtcagaatc attagactga   6300

cttttttttt tccatagtaa tagtattttg cagagtctca cagagctgca gatcttttgt   6360

tcatcttgca gagttaacaa gtctgatcct gttagtccag atttcttaaa tttggccaag   6420

ttataatagg agcagtagct tgagacccga agtcaggaaa ctttgacaat ggattttttt   6480

ttttaatcca gagacttgta ctggaatttg ccttaccctg tcagctcatg gacttaaggt   6540

ttcatcccgc tttatgagtg cttctgaatc caagtcattg ttacctgaat ttgcaaatta   6600

agttgtgata ttcgtgactg ttaaattcct gtaattagat taacctcttt gcttgcttgt   6660

ttgttttctc tcctatttta gcttaaagta tcagtggttg agaagagctt ttcggacctg   6720

ttactacccc aagctgtgta atatacttgt ataacagaaa taccttctat acaaaccttt   6780

ttttctactt ttagatagaa atgtctactt tttcagcagt tctgtgaatt aaagagcaga   6840

gtgactgtgg gtctggaatg gctggtgtac ttgggaatgt actatcagga ttttacagca   6900

atgctgggaa atgacaggga aaatgacagg aatgaatctc accagatttt ttatgtactc   6960

agcagagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct cctacttctc   7020

ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta   7080

gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg ctctccttaa   7140

tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa gctatctctc   7200

atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca cctaacagtc   7260

agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc tcttccactt   7320

ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg gttgaggatt   7380

ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg cgcggattct   7440

taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc attatttcct   7500

agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca gggggctaag   7560

gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt gagatttcac   7620

aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg acggcatagt   7680

tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt agcagaaata   7740

ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt aatcaataaa   7800

atccatccat gcctttcaca cactaagt                                      7828


<210>  4593
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  4593

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile 
        515                 520                 525


Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
545                 550                 555                 560


Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys 
                565                 570                 575


Ser Ser Ser Leu Leu Lys Asn Leu Asn 
            580                 585


<210>  4594
<211>  4263
<212>  DNA
<213>  Homo sapiens

<400>  4594
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1920

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct tagatttgtt   1980

gacagcggtt tcctggagtg ctgtcttgag aacgattctg aggaggctca gcaagaaaga   2040

gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa ctcaagctct tggactcacc   2100

gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc cggagttctt gtatgtggaa   2160

ggcttgccag aggggattcc cttccgaagc cctacctggt ttggaattcc acgacttgaa   2220

aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta aaaaacctga actagttatt   2280

tcctacttgc ctcctgggat ggctagtaaa ataaacacta aagctttgca gtcccccaaa   2340

agaccacgaa gtcctgggag taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc   2400

cctaataaca acaatcctca aacctcagct gttcgaaccc cgacccagac taacggttct   2460

aacgttccct tcaagccacg agggagagag ttttcctttg aggcctggaa tgccaaaatc   2520

acggacctaa aacagaaagt tgaaaatctc ttcaatgaga aatgtgggga agctcttggc   2580

cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt ctttcccgga agacttttat   2640

gtggaaggct tacctgaggg tgtgccattc cgaagaccat cgacttttgg cattccgagg   2700

ctggagaaga tactcagaaa caaagccaaa attaagttca tcattaaaaa gcccgaaatg   2760

tttgagacgg cgattaagga gagcacctcc tctaagagcc ctcccagaaa aataaattca   2820

tcacccaatg ttaatactac tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca   2880

attccagatg atgataatga aagactctcg aaagttgaaa aagctagaca gctaagagaa   2940

caagtgaatg acctctttag tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg   3000

aaagttccct acaggaaaat cacaattaac cctggctgtg tggtggttga tggcatgccc   3060

ccgggggtgt ccttcaaagc ccccagctac ctggaaatca gctccatgag aaggatctta   3120

gactctgccg agtttatcaa attcacggtc attagaccat ttccaggact tgtgattaat   3180

aaccagctgg ttgatcagag tgagtcagaa ggccccgtga tacaagaatc agctgaacca   3240

agccagttgg aagttccagc cacagaagaa ataaaagaga ctgatggaag ctctcagatc   3300

aagcaagaac cagaccccac gtggtagacc tcttccctcc taggcttaaa gtatcagtgg   3360

ttgagaagag cttttcggac ctgttactac cccaagctgt agccttgagt tacggtgttt   3420

attttccaat caagtgaaga tatctcctac ttctcctact ggaacatctc agcttctgca   3480

gtgaagaaaa attcctgtga tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat   3540

catttaaatg atcctttgtt cacggctctc cttaatgact gagtgaacag ttcctatctg   3600

tatatttgac taaacctttt cctaagctat ctctcatggt tcctatgttt ttttatcata   3660

attaaaagca aaaccatctg gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa   3720

ttatagagga aatacagaga gaacctcttc cacttttact tttcgtccaa ataaaatgca   3780

tggtgtacca gaagttgaag atcgggttga ggattggggc tagctcgatg acactaaggc   3840

cccaacatcg cgggacctgc tgtggcgcgg attcttagga acgctgttct agccggcccc   3900

ctctccaggg gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac cctgaggtgc   3960

cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc   4020

ttcctaggag agtcttacat gtgttgagat ttcacaagca atgcgagttg taaaatacca   4080

gctctacaag aagctaggct ctgtgacggc atagttttca gtagctttat cacaatattc   4140

acaatggaga attatatgac atggtagcag aaataggccc ttttatgtgt tgcttctatt   4200

ttacctcaaa ttgtagatat agggtaatca ataaaatcca tccatgcctt tcacacacta   4260

agt                                                                 4263


<210>  4595
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  4595

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
            500                 505                 510


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
        515                 520


<210>  4596
<211>  7944
<212>  DNA
<213>  Homo sapiens

<400>  4596
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1920

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct tagatttgtt   1980

gacagcggtt tcctggagtg ctgtcttgag aacgattctg aggaggctca gcaagaaaga   2040

gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa ctcaagctct tggactcacc   2100

gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc cggagttctt gtatgtggaa   2160

ggcttgccag aggggattcc cttccgaagc cctacctggt ttggaattcc acgacttgaa   2220

aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta aaaaacctga actagttatt   2280

tcctacttgc ctcctgggat ggctagtaaa ataaacacta aagctttgca gtcccccaaa   2340

agaccacgaa gtcctgggag taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc   2400

cctaataaca acaatcctca aacctcagct gttcgaaccc cgacccagac taacggttct   2460

aacgttccct tcaagccacg agggagagag ttttcctttg aggcctggaa tgccaaaatc   2520

acggacctaa aacagaaagt tgaaaatctc ttcaatgaga aatgtgggga agctcttggc   2580

cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt ctttcccgga agacttttat   2640

gtggaaggct tacctgaggg tgtgccattc cgaagaccat cgacttttgg cattccgagg   2700

ctggagaaga tactcagaaa caaagccaaa attaagttca tcattaaaaa gcccgaaatg   2760

tttgagacgg cgattaagga gagcacctcc tctaagagcc ctcccagaaa aataaattca   2820

tcacccaatg ttaatactac tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca   2880

attccagatg atgataatga aagactctcg aaagttgaaa aagctagaca gctaagagaa   2940

caagtgaatg acctctttag tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg   3000

aaagttccct acaggaaaat cacaattaac cctggctgtg tggtggttga tggcatgccc   3060

ccgggggtgt ccttcaaagc ccccagctac ctggaaatca gctccatgag aaggatctta   3120

gactctgccg agtttatcaa attcacggtc attaggtaag tgagagtttc ctgcttagtc   3180

acaggagcga atctggagct catgaggctg actcttctaa aatgcagcca caggtagtca   3240

tcgaatccgg cttcctatgc tgtgcaatca acaaatcaaa ataacttgtg tcatcattag   3300

aatgtcagat gtgcttctac gaactaagct gactctttta attctttggc aaagggttgg   3360

caaactagga ctgtttgcca aattcaggct gcctcctatt tttagagtct tcctgaaaca   3420

cagctacacc cgtattatcc atggctgctt tcctgtcaca gtgagtaagt agctgggact   3480

gagaaggcat ggcctccaaa gtctaaaata tttactctct agcactttgt agaaaaacct   3540

tagctaggca cagtggctaa cgcctgtaat cccagcattt tgggaggcca aggcaggcag   3600

atcacctgag gtcaggagtt ccagaccagc ctggccaaca tggtgaaatc ccatctctac   3660

aaaaataaaa cagttagctg ggcatgatgg cgggtgcctg taatcccagc tactcgggag   3720

gctgaggcag gatagtcgct tgaacccagg aggtggaggt tgcaatgagc caagatcatg   3780

ccactgcact ccagcctgga cgacagagtg agactccatc acaagaaaaa aagaactttg   3840

tcaacctctg tcttagggcg ccttgtcaca ggcttcgggt cagacggatt caaccttgca   3900

tcagccattt gttagccagg tcactctgtt ctttgtctgt aaatgagatt gatcgttgtt   3960

cccactgaga gtgtcagctc cttcccgtag agcaggcatg atgattgtac tcacctctga   4020

caccattgtg agtgccacat tccttcccac gtccttgtca ctgtaagaga tgcccacctg   4080

agcaccaacc ccaggttatc ttcccctttg tcttccagcc ccccagaaac agctacgact   4140

caacctaccc aatcatttca tcatcagatt gccactgtct ctagttcagg tctcttggga   4200

ctggcactca gaaatctcat aataaatcct cttgaggctt ctcatacact cgtcttcttc   4260

caatcttctt tccctcaaaa tctcatattt tggttccact tcacccaccg tcattctcca   4320

tatcactccc aggagttagg caaaaagccc cttccgttct tccgtatgtt aaacttagaa   4380

tcactctgtt ccctgctctg cgtttctatt ttttgttttt cctccattta ctagtagctt   4440

aacactttct aacagtgttc ttattattga tacgtatcta tctcttccat aagcttataa   4500

ggtcacggat aatacttctc attgtagtac gtaaatgacg tgggctagat atgagttgaa   4560

taaacagtta tacctgtaaa ttcttacaga gtgaaaataa attgttatac tttacaattt   4620

gtttctctct ttagaccatt tccaggactt gtgattaata accgtgagta ttttgtgaag   4680

tgttttgttt ttgttttttc ctggggtctg acgtgtgtgc gtgtgagtgt gtatacatgc   4740

ttaacgtata tcacgttact tcacctatgt cagtaaccag gccaaatact tgttttagcc   4800

ctcagtaaaa acaccaggca cttcctagtt gtaaaattat tcaagcttct taacttccta   4860

tcctcgatgc acttaatcat aaaatggtaa taatagcacc gattttgggg gagtcgttcc   4920

agtagatgga aagcatctgg aacaggtgtc agcaagctcc tgccgacgtg tatgcataaa   4980

gttttattga aaccaccatc gtgtccattt gtttatggca gaactgagag atggcagcag   5040

caagtgtgtg cctgcaaaac ctaaaatatt tactaattgg ctctgcaaga aaagagtttg   5100

catcccccta acctagaaca gtgtctagcc tctagtatgt gtttagccta cagtatgtgc   5160

tcagcgaata caatctatat ttattactgc ttttatgact gttataatta ctgtgcttgg   5220

atttcgttac aaagtaagtc acaatgtgcc tgcttctgtt agtatttcag cacagtgcct   5280

ggcacacatg gggctctcaa atattgctga gcgagtgaac aaatgtcctt tcaattcctt   5340

aacgttgatg tcattttcaa tagtattttg agccaaactt aattttgcga gtgtgttttg   5400

ttttcttaac tttattatta aaaatgtata aaagtgaggc caggcgtggt ggctcacgcc   5460

tgtaatccca gcagtttggg aggctgaggc aggcggatca gttgaggttg ggagttggag   5520

accagcccgt ccaacatggt gaaagcctgt ctctactaaa aatacaaaaa tcagctgggt   5580

gtggtggcgc gtgcctgtaa tcccagctac tcaggaggct gaggcaggag agttgcttga   5640

atcctagagg tggaggttgc agtgagctga gatcgtgcca ttgcactcca gcctgggcaa   5700

caagagcaaa actctgtccc aataaataaa taaataaaat gttctctttt gttcctgttc   5760

ttgtgcggta gtgtggtata gagttttatg gtaattactg tgaattagtg attctgaggg   5820

acatatcaga actctgaggt ttgtttcctt ctcatcttga gggaaacagc aaatgtatgt   5880

taaaatgctt ttccaaggga acaacacatc cttacattat ttaaaccaat ctgcttcatt   5940

ttcagagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat cagctgaacc   6000

aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa gctctcagat   6060

caagcaagaa ccagacccca cgtggtagac ctcttccctc ctagggtaaa tcagcttctg   6120

tgtcagggat gctgtgtggt gtccatctga accccctgca tacgcgtagc taatgtgatc   6180

tccccacttt cacataagat ggtggccctg ccttcaggga atgtgggagc caggtgggag   6240

ccttcccgga tatttaagct agaagattct acagggagat tctccttgga tcaatatatg   6300

tctctcagtc aaagatgtaa aagcactttt gccttaaaaa gaatgttctg tttctaaata   6360

gagtcaacgt tgtcctcctc attggaattc actatgagtc agaatcatta gactgacttt   6420

tttttttcca tagtaatagt attttgcaga gtctcacaga gctgcagatc ttttgttcat   6480

cttgcagagt taacaagtct gatcctgtta gtccagattt cttaaatttg gccaagttat   6540

aataggagca gtagcttgag acccgaagtc aggaaacttt gacaatggat tttttttttt   6600

aatccagaga cttgtactgg aatttgcctt accctgtcag ctcatggact taaggtttca   6660

tcccgcttta tgagtgcttc tgaatccaag tcattgttac ctgaatttgc aaattaagtt   6720

gtgatattcg tgactgttaa attcctgtaa ttagattaac ctctttgctt gcttgtttgt   6780

tttctctcct attttagctt aaagtatcag tggttgagaa gagcttttcg gacctgttac   6840

taccccaagc tgtgtaatat acttgtataa cagaaatacc ttctatacaa accttttttt   6900

ctacttttag atagaaatgt ctactttttc agcagttctg tgaattaaag agcagagtga   6960

ctgtgggtct ggaatggctg gtgtacttgg gaatgtacta tcaggatttt acagcaatgc   7020

tgggaaatga cagggaaaat gacaggaatg aatctcacca gattttttat gtactcagca   7080

gagccttgag ttacggtgtt tattttccaa tcaagtgaag atatctccta cttctcctac   7140

tggaacatct cagcttctgc agtgaagaaa aattcctgtg atagttcagt tctttagttt   7200

ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt tcacggctct ccttaatgac   7260

tgagtgaaca gttcctatct gtatatttga ctaaaccttt tcctaagcta tctctcatgg   7320

ttcctatgtt tttttatcat aattaaaagc aaaaccatct ggatcaccta acagtcagag   7380

gtcagtatct cagcgtgtga attatagagg aaatacagag agaacctctt ccacttttac   7440

ttttcgtcca aataaaatgc atggtgtacc agaagttgaa gatcgggttg aggattgggg   7500

ctagctcgat gacactaagg ccccaacatc gcgggacctg ctgtggcgcg gattcttagg   7560

aacgctgttc tagccggccc cctctccagg ggtcgccgtg gccggcatta tttcctagtt   7620

cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg gctaaggatg   7680

caacctctga cgttctgcgc cttcctagga gagtcttaca tgtgttgaga tttcacaagc   7740

aatgcgagtt gtaaaatacc agctctacaa gaagctaggc tctgtgacgg catagttttc   7800

agtagcttta tcacaatatt cacaatggag aattatatga catggtagca gaaataggcc   7860

cttttatgtg ttgcttctat tttacctcaa attgtagata tagggtaatc aataaaatcc   7920

atccatgcct ttcacacact aagt                                          7944


<210>  4597
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  4597

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
            500                 505                 510


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
        515                 520


<210>  4598
<211>  4929
<212>  DNA
<213>  Homo sapiens

<400>  4598
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1980

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   2040

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2100

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2160

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2220

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2280

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2340

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2400

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2460

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2520

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2580

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2640

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2700

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2760

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2820

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2880

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   2940

cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg atcagagtga   3000

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   3060

agaaggtaaa aggacctctt ccctcctagg gtaaatcagc ttctgtgtca gggatgctgt   3120

gtggtgtcca tctgaacccc ctgcatacgc gtagctaatg tgatctcccc actttcacat   3180

aagatggtgg ccctgccttc agggaatgtg ggagccaggt gggagccttc ccggatattt   3240

aagctagaag attctacagg gagattctcc ttggatcaat atatgtctct cagtcaaaga   3300

tgtaaaagca cttttgcctt aaaaagaatg ttctgtttct aaatagagtc aacgttgtcc   3360

tcctcattgg aattcactat gagtcagaat cattagactg actttttttt ttccatagta   3420

atagtatttt gcagagtctc acagagctgc agatcttttg ttcatcttgc agagttaaca   3480

agtctgatcc tgttagtcca gatttcttaa atttggccaa gttataatag gagcagtagc   3540

ttgagacccg aagtcaggaa actttgacaa tggatttttt tttttaatcc agagacttgt   3600

actggaattt gccttaccct gtcagctcat ggacttaagg tttcatcccg ctttatgagt   3660

gcttctgaat ccaagtcatt gttacctgaa tttgcaaatt aagttgtgat attcgtgact   3720

gttaaattcc tgtaattaga ttaacctctt tgcttgcttg tttgttttct ctcctatttt   3780

agcttaaagt atcagtggtt gagaagagct tttcggacct gttactaccc caagctgtgt   3840

aatatacttg tataacagaa ataccttcta tacaaacctt tttttctact tttagataga   3900

aatgtctact ttttcagcag ttctgtgaat taaagagcag agtgactgtg ggtctggaat   3960

ggctggtgta cttgggaatg tactatcagg attttacagc aatgctggga aatgacaggg   4020

aaaatgacag gaatgaatct caccagattt tttatgtact cagcagagcc ttgagttacg   4080

gtgtttattt tccaatcaag tgaagatatc tcctacttct cctactggaa catctcagct   4140

tctgcagtga agaaaaattc ctgtgatagt tcagttcttt agtttttcta tttgaaaaaa   4200

aaaaatcatt taaatgatcc tttgttcacg gctctcctta atgactgagt gaacagttcc   4260

tatctgtata tttgactaaa ccttttccta agctatctct catggttcct atgttttttt   4320

atcataatta aaagcaaaac catctggatc acctaacagt cagaggtcag tatctcagcg   4380

tgtgaattat agaggaaata cagagagaac ctcttccact tttacttttc gtccaaataa   4440

aatgcatggt gtaccagaag ttgaagatcg ggttgaggat tggggctagc tcgatgacac   4500

taaggcccca acatcgcggg acctgctgtg gcgcggattc ttaggaacgc tgttctagcc   4560

ggccccctct ccaggggtcg ccgtggccgg cattatttcc tagttcttct tgtaaccctg   4620

aggtgccagc gcggggagtg aggaggggtc agggggctaa ggatgcaacc tctgacgttc   4680

tgcgccttcc taggagagtc ttacatgtgt tgagatttca caagcaatgc gagttgtaaa   4740

ataccagctc tacaagaagc taggctctgt gacggcatag ttttcagtag ctttatcaca   4800

atattcacaa tggagaatta tatgacatgg tagcagaaat aggccctttt atgtgttgct   4860

tctattttac ctcaaattgt agatataggg taatcaataa aatccatcca tgcctttcac   4920

acactaagt                                                           4929


<210>  4599
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  4599

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
            420                 425                 430


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
        435                 440                 445


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
    450                 455                 460


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser 
465                 470                 475                 480


Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
                485                 490                 495


<210>  4600
<211>  5076
<212>  DNA
<213>  Homo sapiens

<400>  4600
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   2040

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2100

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2160

tgaaaggatc gtccgcggga gtaataaaat caagttcgtt gttaaaaaac ctgaactagt   2220

tatttcctac ttgcctcctg ggatggctag taaaataaac actaaagctt tgcagtcccc   2280

caaaagacca cgaagtcctg ggagtaattc aaaggttcct gaaattgagg tcaccgtgga   2340

aggccctaat aacaacaatc ctcaaacctc agctgttcga accccgaccc agactaacgg   2400

ttctaacgtt cccttcaagc cacgagggag agagttttcc tttgaggcct ggaatgccaa   2460

aatcacggac ctaaaacaga aagttgaaaa tctcttcaat gagaaatgtg gggaagctct   2520

tggccttaaa caagctgtga aggtgccgtt cgcgttattt gagtctttcc cggaagactt   2580

ttatgtggaa ggcttacctg agggtgtgcc attccgaaga ccatcgactt ttggcattcc   2640

gaggctggag aagatactca gaaacaaagc caaaattaag ttcatcatta aaaagcccga   2700

aatgtttgag acggcgatta aggagagcac ctcctctaag agccctccca gaaaaataaa   2760

ttcatcaccc aatgttaata ctactgcatc aggtgttgaa gaccttaaca tcattcaggt   2820

gacaattcca gatgatgata atgaaagact ctcgaaagtt gaaaaagcta gacagctaag   2880

agaacaagtg aatgacctct ttagtcggaa atttggtgaa gctattggta tgggttttcc   2940

tgtgaaagtt ccctacagga aaatcacaat taaccctggc tgtgtggtgg ttgatggcat   3000

gcccccgggg gtgtccttca aagcccccag ctacctggaa atcagctcca tgagaaggat   3060

cttagactct gccgagttta tcaaattcac ggtcattaga ccatttccag gacttgtgat   3120

taataaccag ctggttgatc agagtgagtc agaaggcccc gtgatacaag aatcagctga   3180

accaagccag ttggaagttc cagccacaga aggtaaaagg acctcttccc tcctagggta   3240

aatcagcttc tgtgtcaggg atgctgtgtg gtgtccatct gaaccccctg catacgcgta   3300

gctaatgtga tctccccact ttcacataag atggtggccc tgccttcagg gaatgtggga   3360

gccaggtggg agccttcccg gatatttaag ctagaagatt ctacagggag attctccttg   3420

gatcaatata tgtctctcag tcaaagatgt aaaagcactt ttgccttaaa aagaatgttc   3480

tgtttctaaa tagagtcaac gttgtcctcc tcattggaat tcactatgag tcagaatcat   3540

tagactgact tttttttttc catagtaata gtattttgca gagtctcaca gagctgcaga   3600

tcttttgttc atcttgcaga gttaacaagt ctgatcctgt tagtccagat ttcttaaatt   3660

tggccaagtt ataataggag cagtagcttg agacccgaag tcaggaaact ttgacaatgg   3720

attttttttt ttaatccaga gacttgtact ggaatttgcc ttaccctgtc agctcatgga   3780

cttaaggttt catcccgctt tatgagtgct tctgaatcca agtcattgtt acctgaattt   3840

gcaaattaag ttgtgatatt cgtgactgtt aaattcctgt aattagatta acctctttgc   3900

ttgcttgttt gttttctctc ctattttagc ttaaagtatc agtggttgag aagagctttt   3960

cggacctgtt actaccccaa gctgtgtaat atacttgtat aacagaaata ccttctatac   4020

aaaccttttt ttctactttt agatagaaat gtctactttt tcagcagttc tgtgaattaa   4080

agagcagagt gactgtgggt ctggaatggc tggtgtactt gggaatgtac tatcaggatt   4140

ttacagcaat gctgggaaat gacagggaaa atgacaggaa tgaatctcac cagatttttt   4200

atgtactcag cagagccttg agttacggtg tttattttcc aatcaagtga agatatctcc   4260

tacttctcct actggaacat ctcagcttct gcagtgaaga aaaattcctg tgatagttca   4320

gttctttagt ttttctattt gaaaaaaaaa aatcatttaa atgatccttt gttcacggct   4380

ctccttaatg actgagtgaa cagttcctat ctgtatattt gactaaacct tttcctaagc   4440

tatctctcat ggttcctatg tttttttatc ataattaaaa gcaaaaccat ctggatcacc   4500

taacagtcag aggtcagtat ctcagcgtgt gaattataga ggaaatacag agagaacctc   4560

ttccactttt acttttcgtc caaataaaat gcatggtgta ccagaagttg aagatcgggt   4620

tgaggattgg ggctagctcg atgacactaa ggccccaaca tcgcgggacc tgctgtggcg   4680

cggattctta ggaacgctgt tctagccggc cccctctcca ggggtcgccg tggccggcat   4740

tatttcctag ttcttcttgt aaccctgagg tgccagcgcg gggagtgagg aggggtcagg   4800

gggctaagga tgcaacctct gacgttctgc gccttcctag gagagtctta catgtgttga   4860

gatttcacaa gcaatgcgag ttgtaaaata ccagctctac aagaagctag gctctgtgac   4920

ggcatagttt tcagtagctt tatcacaata ttcacaatgg agaattatat gacatggtag   4980

cagaaatagg cccttttatg tgttgcttct attttacctc aaattgtaga tatagggtaa   5040

tcaataaaat ccatccatgc ctttcacaca ctaagt                             5076


<210>  4601
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  4601

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala 
            580                 585                 590


Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600                 605


<210>  4602
<211>  7908
<212>  DNA
<213>  Homo sapiens

<400>  4602
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2040

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2100

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2160

tgaatcaaac ccggagttct tgaaaggatc gtccgcggga gtaataaaat caagttcgtt   2220

gttaaaaaac ctgaactagt tatttcctac ttgcctcctg ggatggctag taaaataaac   2280

actaaagctt tgcagtcccc caaaagacca cgaagtcctg ggagtaattc aaaggttcct   2340

gaaattgagg tcaccgtgga aggccctaat aacaacaatc ctcaaacctc agctgttcga   2400

accccgaccc agactaacgg ttctaacgtt cccttcaagc cacgagggag agagttttcc   2460

tttgaggcct ggaatgccaa aatcacggac ctaaaacaga aagttgaaaa tctcttcaat   2520

gagaaatgtg gggaagctct tggccttaaa caagctgtga aggtgccgtt cgcgttattt   2580

gagtctttcc cggaagactt ttatgtggaa ggcttacctg agggtgtgcc attccgaaga   2640

ccatcgactt ttggcattcc gaggctggag aagatactca gaaacaaagc caaaattaag   2700

ttcatcatta aaaagcccga aatgtttgag acggcgatta aggagagcac ctcctctaag   2760

agccctccca gaaaaataaa ttcatcaccc aatgttaata ctactgcatc aggtgttgaa   2820

gaccttaaca tcattcaggt gacaattcca gatgatgata atgaaagact ctcgaaagtt   2880

gaaaaagcta gacagctaag agaacaagtg aatgacctct ttagtcggaa atttggtgaa   2940

gctattggta tgggttttcc tgtgaaagtt ccctacagga aaatcacaat taaccctggc   3000

tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca aagcccccag ctacctggaa   3060

atcagctcca tgagaaggat cttagactct gccgagttta tcaaattcac ggtcattagg   3120

taagtgagag tttcctgctt agtcacagga gcgaatctgg agctcatgag gctgactctt   3180

ctaaaatgca gccacaggta gtcatcgaat ccggcttcct atgctgtgca atcaacaaat   3240

caaaataact tgtgtcatca ttagaatgtc agatgtgctt ctacgaacta agctgactct   3300

tttaattctt tggcaaaggg ttggcaaact aggactgttt gccaaattca ggctgcctcc   3360

tatttttaga gtcttcctga aacacagcta cacccgtatt atccatggct gctttcctgt   3420

cacagtgagt aagtagctgg gactgagaag gcatggcctc caaagtctaa aatatttact   3480

ctctagcact ttgtagaaaa accttagcta ggcacagtgg ctaacgcctg taatcccagc   3540

attttgggag gccaaggcag gcagatcacc tgaggtcagg agttccagac cagcctggcc   3600

aacatggtga aatcccatct ctacaaaaat aaaacagtta gctgggcatg atggcgggtg   3660

cctgtaatcc cagctactcg ggaggctgag gcaggatagt cgcttgaacc caggaggtgg   3720

aggttgcaat gagccaagat catgccactg cactccagcc tggacgacag agtgagactc   3780

catcacaaga aaaaaagaac tttgtcaacc tctgtcttag ggcgccttgt cacaggcttc   3840

gggtcagacg gattcaacct tgcatcagcc atttgttagc caggtcactc tgttctttgt   3900

ctgtaaatga gattgatcgt tgttcccact gagagtgtca gctccttccc gtagagcagg   3960

catgatgatt gtactcacct ctgacaccat tgtgagtgcc acattccttc ccacgtcctt   4020

gtcactgtaa gagatgccca cctgagcacc aaccccaggt tatcttcccc tttgtcttcc   4080

agccccccag aaacagctac gactcaacct acccaatcat ttcatcatca gattgccact   4140

gtctctagtt caggtctctt gggactggca ctcagaaatc tcataataaa tcctcttgag   4200

gcttctcata cactcgtctt cttccaatct tctttccctc aaaatctcat attttggttc   4260

cacttcaccc accgtcattc tccatatcac tcccaggagt taggcaaaaa gccccttccg   4320

ttcttccgta tgttaaactt agaatcactc tgttccctgc tctgcgtttc tattttttgt   4380

ttttcctcca tttactagta gcttaacact ttctaacagt gttcttatta ttgatacgta   4440

tctatctctt ccataagctt ataaggtcac ggataatact tctcattgta gtacgtaaat   4500

gacgtgggct agatatgagt tgaataaaca gttatacctg taaattctta cagagtgaaa   4560

ataaattgtt atactttaca atttgtttct ctctttagac catttccagg acttgtgatt   4620

aataaccgtg agtattttgt gaagtgtttt gtttttgttt tttcctgggg tctgacgtgt   4680

gtgcgtgtga gtgtgtatac atgcttaacg tatatcacgt tacttcacct atgtcagtaa   4740

ccaggccaaa tacttgtttt agccctcagt aaaaacacca ggcacttcct agttgtaaaa   4800

ttattcaagc ttcttaactt cctatcctcg atgcacttaa tcataaaatg gtaataatag   4860

caccgatttt gggggagtcg ttccagtaga tggaaagcat ctggaacagg tgtcagcaag   4920

ctcctgccga cgtgtatgca taaagtttta ttgaaaccac catcgtgtcc atttgtttat   4980

ggcagaactg agagatggca gcagcaagtg tgtgcctgca aaacctaaaa tatttactaa   5040

ttggctctgc aagaaaagag tttgcatccc cctaacctag aacagtgtct agcctctagt   5100

atgtgtttag cctacagtat gtgctcagcg aatacaatct atatttatta ctgcttttat   5160

gactgttata attactgtgc ttggatttcg ttacaaagta agtcacaatg tgcctgcttc   5220

tgttagtatt tcagcacagt gcctggcaca catggggctc tcaaatattg ctgagcgagt   5280

gaacaaatgt cctttcaatt ccttaacgtt gatgtcattt tcaatagtat tttgagccaa   5340

acttaatttt gcgagtgtgt tttgttttct taactttatt attaaaaatg tataaaagtg   5400

aggccaggcg tggtggctca cgcctgtaat cccagcagtt tgggaggctg aggcaggcgg   5460

atcagttgag gttgggagtt ggagaccagc ccgtccaaca tggtgaaagc ctgtctctac   5520

taaaaataca aaaatcagct gggtgtggtg gcgcgtgcct gtaatcccag ctactcagga   5580

ggctgaggca ggagagttgc ttgaatccta gaggtggagg ttgcagtgag ctgagatcgt   5640

gccattgcac tccagcctgg gcaacaagag caaaactctg tcccaataaa taaataaata   5700

aaatgttctc ttttgttcct gttcttgtgc ggtagtgtgg tatagagttt tatggtaatt   5760

actgtgaatt agtgattctg agggacatat cagaactctg aggtttgttt ccttctcatc   5820

ttgagggaaa cagcaaatgt atgttaaaat gcttttccaa gggaacaaca catccttaca   5880

ttatttaaac caatctgctt cattttcaga gctggttgat cagagtgagt cagaaggccc   5940

cgtgatacaa gaatcagctg aaccaagcca gttggaagtt ccagccacag aagaaataaa   6000

agagactgat ggaagctctc agatcaagca agaaccagac cccacgtggt agacctcttc   6060

cctcctaggg taaatcagct tctgtgtcag ggatgctgtg tggtgtccat ctgaaccccc   6120

tgcatacgcg tagctaatgt gatctcccca ctttcacata agatggtggc cctgccttca   6180

gggaatgtgg gagccaggtg ggagccttcc cggatattta agctagaaga ttctacaggg   6240

agattctcct tggatcaata tatgtctctc agtcaaagat gtaaaagcac ttttgcctta   6300

aaaagaatgt tctgtttcta aatagagtca acgttgtcct cctcattgga attcactatg   6360

agtcagaatc attagactga cttttttttt tccatagtaa tagtattttg cagagtctca   6420

cagagctgca gatcttttgt tcatcttgca gagttaacaa gtctgatcct gttagtccag   6480

atttcttaaa tttggccaag ttataatagg agcagtagct tgagacccga agtcaggaaa   6540

ctttgacaat ggattttttt ttttaatcca gagacttgta ctggaatttg ccttaccctg   6600

tcagctcatg gacttaaggt ttcatcccgc tttatgagtg cttctgaatc caagtcattg   6660

ttacctgaat ttgcaaatta agttgtgata ttcgtgactg ttaaattcct gtaattagat   6720

taacctcttt gcttgcttgt ttgttttctc tcctatttta gcttaaagta tcagtggttg   6780

agaagagctt ttcggacctg ttactacccc aagctgtgta atatacttgt ataacagaaa   6840

taccttctat acaaaccttt ttttctactt ttagatagaa atgtctactt tttcagcagt   6900

tctgtgaatt aaagagcaga gtgactgtgg gtctggaatg gctggtgtac ttgggaatgt   6960

actatcagga ttttacagca atgctgggaa atgacaggga aaatgacagg aatgaatctc   7020

accagatttt ttatgtactc agcagagcct tgagttacgg tgtttatttt ccaatcaagt   7080

gaagatatct cctacttctc ctactggaac atctcagctt ctgcagtgaa gaaaaattcc   7140

tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct   7200

ttgttcacgg ctctccttaa tgactgagtg aacagttcct atctgtatat ttgactaaac   7260

cttttcctaa gctatctctc atggttccta tgttttttta tcataattaa aagcaaaacc   7320

atctggatca cctaacagtc agaggtcagt atctcagcgt gtgaattata gaggaaatac   7380

agagagaacc tcttccactt ttacttttcg tccaaataaa atgcatggtg taccagaagt   7440

tgaagatcgg gttgaggatt ggggctagct cgatgacact aaggccccaa catcgcggga   7500

cctgctgtgg cgcggattct taggaacgct gttctagccg gccccctctc caggggtcgc   7560

cgtggccggc attatttcct agttcttctt gtaaccctga ggtgccagcg cggggagtga   7620

ggaggggtca gggggctaag gatgcaacct ctgacgttct gcgccttcct aggagagtct   7680

tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa taccagctct acaagaagct   7740

aggctctgtg acggcatagt tttcagtagc tttatcacaa tattcacaat ggagaattat   7800

atgacatggt agcagaaata ggccctttta tgtgttgctt ctattttacc tcaaattgta   7860

gatatagggt aatcaataaa atccatccat gcctttcaca cactaagt                7908


<210>  4603
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  4603

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala 
            580                 585                 590


Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600                 605


<210>  4604
<211>  4989
<212>  DNA
<213>  Homo sapiens

<400>  4604
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1980

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   2040

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   2100

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2160

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2220

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2280

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2340

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2400

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2460

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2520

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2580

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2640

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2700

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2760

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2820

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2880

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2940

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   3000

cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg atcagagtga   3060

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   3120

agaaggtaaa aggacctctt ccctcctagg gtaaatcagc ttctgtgtca gggatgctgt   3180

gtggtgtcca tctgaacccc ctgcatacgc gtagctaatg tgatctcccc actttcacat   3240

aagatggtgg ccctgccttc agggaatgtg ggagccaggt gggagccttc ccggatattt   3300

aagctagaag attctacagg gagattctcc ttggatcaat atatgtctct cagtcaaaga   3360

tgtaaaagca cttttgcctt aaaaagaatg ttctgtttct aaatagagtc aacgttgtcc   3420

tcctcattgg aattcactat gagtcagaat cattagactg actttttttt ttccatagta   3480

atagtatttt gcagagtctc acagagctgc agatcttttg ttcatcttgc agagttaaca   3540

agtctgatcc tgttagtcca gatttcttaa atttggccaa gttataatag gagcagtagc   3600

ttgagacccg aagtcaggaa actttgacaa tggatttttt tttttaatcc agagacttgt   3660

actggaattt gccttaccct gtcagctcat ggacttaagg tttcatcccg ctttatgagt   3720

gcttctgaat ccaagtcatt gttacctgaa tttgcaaatt aagttgtgat attcgtgact   3780

gttaaattcc tgtaattaga ttaacctctt tgcttgcttg tttgttttct ctcctatttt   3840

agcttaaagt atcagtggtt gagaagagct tttcggacct gttactaccc caagctgtgt   3900

aatatacttg tataacagaa ataccttcta tacaaacctt tttttctact tttagataga   3960

aatgtctact ttttcagcag ttctgtgaat taaagagcag agtgactgtg ggtctggaat   4020

ggctggtgta cttgggaatg tactatcagg attttacagc aatgctggga aatgacaggg   4080

aaaatgacag gaatgaatct caccagattt tttatgtact cagcagagcc ttgagttacg   4140

gtgtttattt tccaatcaag tgaagatatc tcctacttct cctactggaa catctcagct   4200

tctgcagtga agaaaaattc ctgtgatagt tcagttcttt agtttttcta tttgaaaaaa   4260

aaaaatcatt taaatgatcc tttgttcacg gctctcctta atgactgagt gaacagttcc   4320

tatctgtata tttgactaaa ccttttccta agctatctct catggttcct atgttttttt   4380

atcataatta aaagcaaaac catctggatc acctaacagt cagaggtcag tatctcagcg   4440

tgtgaattat agaggaaata cagagagaac ctcttccact tttacttttc gtccaaataa   4500

aatgcatggt gtaccagaag ttgaagatcg ggttgaggat tggggctagc tcgatgacac   4560

taaggcccca acatcgcggg acctgctgtg gcgcggattc ttaggaacgc tgttctagcc   4620

ggccccctct ccaggggtcg ccgtggccgg cattatttcc tagttcttct tgtaaccctg   4680

aggtgccagc gcggggagtg aggaggggtc agggggctaa ggatgcaacc tctgacgttc   4740

tgcgccttcc taggagagtc ttacatgtgt tgagatttca caagcaatgc gagttgtaaa   4800

ataccagctc tacaagaagc taggctctgt gacggcatag ttttcagtag ctttatcaca   4860

atattcacaa tggagaatta tatgacatgg tagcagaaat aggccctttt atgtgttgct   4920

tctattttac ctcaaattgt agatataggg taatcaataa aatccatcca tgcctttcac   4980

acactaagt                                                           4989


<210>  4605
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  4605

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
    450                 455                 460


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
465                 470                 475                 480


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
                485                 490                 495


Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys 
            500                 505                 510


Asn Leu Asn 
        515


<210>  4606
<211>  3820
<212>  DNA
<213>  Homo sapiens

<400>  4606
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1980

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   2040

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttga   2100

aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg aactagttat   2160

ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc agtcccccaa   2220

aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg   2280

ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga ctaacggttc   2340

taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga atgccaaaat   2400

cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg   2460

ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg aagactttta   2520

tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg gcattccgag   2580

gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa agcccgaaat   2640

gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa aaataaattc   2700

atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca ttcaggtgac   2760

aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac agctaagaga   2820

acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg gttttcctgt   2880

gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg atggcatgcc   2940

cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga gaaggatctt   3000

agactctgcc gagtttatca aattcacggt cattagacca tttccaggac ttgtgattaa   3060

taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat cagctgaacc   3120

aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa gctctcagat   3180

caagcaagaa ccagacccca cgtggtagac ctcttccctc ctaggcaaaa ccatctggat   3240

cacctaacag tcagaggtca gtatctcagc gtgtgaatta tagaggaaat acagagagaa   3300

cctcttccac ttttactttt cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc   3360

gggttgagga ttggggctag ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt   3420

ggcgcggatt cttaggaacg ctgttctagc cggccccctc tccaggggtc gccgtggccg   3480

gcattatttc ctagttcttc ttgtaaccct gaggtgccag cgcggggagt gaggaggggt   3540

cagggggcta aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg   3600

ttgagatttc acaagcaatg cgagttgtaa aataccagct ctacaagaag ctaggctctg   3660

tgacggcata gttttcagta gctttatcac aatattcaca atggagaatt atatgacatg   3720

gtagcagaaa taggcccttt tatgtgttgc ttctatttta cctcaaattg tagatatagg   3780

gtaatcaata aaatccatcc atgcctttca cacactaagt                         3820


<210>  4607
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  4607

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
                565                 570                 575


Ser Ser Leu Leu Lys Asn Leu Asn 
            580


<210>  4608
<211>  3939
<212>  DNA
<213>  Homo sapiens

<400>  4608
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1920

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct tagatttgtt   1980

gacagcggtt tcctggagtg ctgtcttgag aacgattctg aggaggctca gcaagaaaga   2040

gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa ctcaagctct tggactcacc   2100

gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc cggagttctt gtatgtggaa   2160

ggcttgccag aggggattcc cttccgaagc cctacctggt ttggaattcc acgacttgaa   2220

aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta aaaaacctga actagttatt   2280

tcctacttgc ctcctgggat ggctagtaaa ataaacacta aagctttgca gtcccccaaa   2340

agaccacgaa gtcctgggag taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc   2400

cctaataaca acaatcctca aacctcagct gttcgaaccc cgacccagac taacggttct   2460

aacgttccct tcaagccacg agggagagag ttttcctttg aggcctggaa tgccaaaatc   2520

acggacctaa aacagaaagt tgaaaatctc ttcaatgaga aatgtgggga agctcttggc   2580

cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt ctttcccgga agacttttat   2640

gtggaaggct tacctgaggg tgtgccattc cgaagaccat cgacttttgg cattccgagg   2700

ctggagaaga tactcagaaa caaagccaaa attaagttca tcattaaaaa gcccgaaatg   2760

tttgagacgg cgattaagga gagcacctcc tctaagagcc ctcccagaaa aataaattca   2820

tcacccaatg ttaatactac tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca   2880

attccagatg atgataatga aagactctcg aaagttgaaa aagctagaca gctaagagaa   2940

caagtgaatg acctctttag tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg   3000

aaagttccct acaggaaaat cacaattaac cctggctgtg tggtggttga tggcatgccc   3060

ccgggggtgt ccttcaaagc ccccagctac ctggaaatca gctccatgag aaggatctta   3120

gactctgccg agtttatcaa attcacggtc attagaccat ttccaggact tgtgattaat   3180

aaccagctgg ttgatcagag tgagtcagaa ggccccgtga tacaagaatc agctgaacca   3240

agccagttgg aagttccagc cacagaagaa ataaaagaga ctgatggaag ctctcagatc   3300

aagcaagaac cagaccccac gtggtagacc tcttccctcc taggcaaaac catctggatc   3360

acctaacagt cagaggtcag tatctcagcg tgtgaattat agaggaaata cagagagaac   3420

ctcttccact tttacttttc gtccaaataa aatgcatggt gtaccagaag ttgaagatcg   3480

ggttgaggat tggggctagc tcgatgacac taaggcccca acatcgcggg acctgctgtg   3540

gcgcggattc ttaggaacgc tgttctagcc ggccccctct ccaggggtcg ccgtggccgg   3600

cattatttcc tagttcttct tgtaaccctg aggtgccagc gcggggagtg aggaggggtc   3660

agggggctaa ggatgcaacc tctgacgttc tgcgccttcc taggagagtc ttacatgtgt   3720

tgagatttca caagcaatgc gagttgtaaa ataccagctc tacaagaagc taggctctgt   3780

gacggcatag ttttcagtag ctttatcaca atattcacaa tggagaatta tatgacatgg   3840

tagcagaaat aggccctttt atgtgttgct tctattttac ctcaaattgt agatataggg   3900

taatcaataa aatccatcca tgcctttcac acactaagt                          3939


<210>  4609
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  4609

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
            500                 505                 510


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
        515                 520


<210>  4610
<211>  3907
<212>  DNA
<213>  Homo sapiens

<400>  4610
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   1980

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2040

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2100

atcaaacccg gagttcttgt atgtggaagg cttgccagag gggattccct tccgaagccc   2160

tacctggttt ggaattccac gacttgaaag gatcgtccgc gggagtaata aaatcaagtt   2220

cgttgttaaa aaacctgaac tagttatttc ctacttgcct cctgggatgg ctagtaaaat   2280

aaacactaaa gctttgcagt cccccaaaag accacgaagt cctgggagta attcaaaggt   2340

tcctgaaatt gaggtcaccg tggaaggccc taataacaac aatcctcaaa cctcagctgt   2400

tcgaaccccg acccagacta acggttctaa cgttcccttc aagccacgag ggagagagtt   2460

ttcctttgag gcctggaatg ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt   2520

caatgagaaa tgtggggaag ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt   2580

atttgagtct ttcccggaag acttttatgt ggaaggctta cctgagggtg tgccattccg   2640

aagaccatcg acttttggca ttccgaggct ggagaagata ctcagaaaca aagccaaaat   2700

taagttcatc attaaaaagc ccgaaatgtt tgagacggcg attaaggaga gcacctcctc   2760

taagagccct cccagaaaaa taaattcatc acccaatgtt aatactactg catcaggtgt   2820

tgaagacctt aacatcattc aggtgacaat tccagatgat gataatgaaa gactctcgaa   2880

agttgaaaaa gctagacagc taagagaaca agtgaatgac ctctttagtc ggaaatttgg   2940

tgaagctatt ggtatgggtt ttcctgtgaa agttccctac aggaaaatca caattaaccc   3000

tggctgtgtg gtggttgatg gcatgccccc gggggtgtcc ttcaaagccc ccagctacct   3060

ggaaatcagc tccatgagaa ggatcttaga ctctgccgag tttatcaaat tcacggtcat   3120

tagaccattt ccaggacttg tgattaataa ccagctggtt gatcagagtg agtcagaagg   3180

ccccgtgata caagaatcag ctgaaccaag ccagttggaa gttccagcca cagaagaaat   3240

aaaagagact gatggaagct ctcagatcaa gcaagaacca gaccccacgt ggtagacctc   3300

ttccctccta ggcaaaacca tctggatcac ctaacagtca gaggtcagta tctcagcgtg   3360

tgaattatag aggaaataca gagagaacct cttccacttt tacttttcgt ccaaataaaa   3420

tgcatggtgt accagaagtt gaagatcggg ttgaggattg gggctagctc gatgacacta   3480

aggccccaac atcgcgggac ctgctgtggc gcggattctt aggaacgctg ttctagccgg   3540

ccccctctcc aggggtcgcc gtggccggca ttatttccta gttcttcttg taaccctgag   3600

gtgccagcgc ggggagtgag gaggggtcag ggggctaagg atgcaacctc tgacgttctg   3660

cgccttccta ggagagtctt acatgtgttg agatttcaca agcaatgcga gttgtaaaat   3720

accagctcta caagaagcta ggctctgtga cggcatagtt ttcagtagct ttatcacaat   3780

attcacaatg gagaattata tgacatggta gcagaaatag gcccttttat gtgttgcttc   3840

tattttacct caaattgtag atatagggta atcaataaaa tccatccatg cctttcacac   3900

actaagt                                                             3907


<210>  4611
<211>  957
<212>  PRT
<213>  Homo sapiens

<400>  4611

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
                565                 570                 575


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
            580                 585                 590


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
        595                 600                 605


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
    610                 615                 620


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
625                 630                 635                 640


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
                645                 650                 655


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
            660                 665                 670


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
        675                 680                 685


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
    690                 695                 700


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
705                 710                 715                 720


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
                725                 730                 735


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
            740                 745                 750


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
        755                 760                 765


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
    770                 775                 780


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
785                 790                 795                 800


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
                805                 810                 815


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
            820                 825                 830


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
        835                 840                 845


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
    850                 855                 860


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
865                 870                 875                 880


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
                885                 890                 895


Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu 
            900                 905                 910


Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu 
        915                 920                 925


Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp 
    930                 935                 940


Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950                 955


<210>  4612
<211>  4091
<212>  DNA
<213>  Homo sapiens

<400>  4612
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   1980

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2040

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2100

tgaaaggatc gtccgcggga gtaataaaat caagttcgtt gttaaaaaac ctgaactagt   2160

tatttcctac ttgcctcctg ggatggctag taaaataaac actaaagctt tgcagtcccc   2220

caaaagacca cgaagtcctg ggagtaattc aaaggttcct gaaattgagg tcaccgtgga   2280

aggccctaat aacaacaatc ctcaaacctc agctgttcga accccgaccc agactaacgg   2340

ttctaacgtt cccttcaagc cacgagggag agagttttcc tttgaggcct ggaatgccaa   2400

aatcacggac ctaaaacaga aagttgaaaa tctcttcaat gagaaatgtg gggaagctct   2460

tggccttaaa caagctgtga aggtgccgtt cgcgttattt gagtctttcc cggaagactt   2520

ttatgtggaa ggcttacctg agggtgtgcc attccgaaga ccatcgactt ttggcattcc   2580

gaggctggag aagatactca gaaacaaagc caaaattaag ttcatcatta aaaagcccga   2640

aatgtttgag acggcgatta aggagagcac ctcctctaag agccctccca gaaaaataaa   2700

ttcatcaccc aatgttaata ctactgcatc aggtgttgaa gaccttaaca tcattcaggt   2760

gacaattcca gatgatgata atgaaagact ctcgaaagtt gaaaaagcta gacagctaag   2820

agaacaagtg aatgacctct ttagtcggaa atttggtgaa gctattggta tgggttttcc   2880

tgtgaaagtt ccctacagga aaatcacaat taaccctggc tgtgtggtgg ttgatggcat   2940

gcccccgggg gtgtccttca aagcccccag ctacctggaa atcagctcca tgagaaggat   3000

cttagactct gccgagttta tcaaattcac ggtcattaga ccatttccag gacttgtgat   3060

taataaccag ctggttgatc agagtgagtc agaaggcccc gtgatacaag aatcagctga   3120

accaagccag ttggaagttc cagccacaga agaaataaaa gagactgatg gaagctctca   3180

gatcaagcaa gaaccagacc ccacgtggta gacctcttcc ctcctaggag ccttgagtta   3240

cggtgtttat tttccaatca agtgaagata tctcctactt ctcctactgg aacatctcag   3300

cttctgcagt gaagaaaaat tcctgtgata gttcagttct ttagtttttc tatttgaaaa   3360

aaaaaaatca tttaaatgat cctttgttca cggctctcct taatgactga gtgaacagtt   3420

cctatctgta tatttgacta aaccttttcc taagctatct ctcatggttc ctatgttttt   3480

ttatcataat taaaagcaaa accatctgga tcacctaaca gtcagaggtc agtatctcag   3540

cgtgtgaatt atagaggaaa tacagagaga acctcttcca cttttacttt tcgtccaaat   3600

aaaatgcatg gtgtaccaga agttgaagat cgggttgagg attggggcta gctcgatgac   3660

actaaggccc caacatcgcg ggacctgctg tggcgcggat tcttaggaac gctgttctag   3720

ccggccccct ctccaggggt cgccgtggcc ggcattattt cctagttctt cttgtaaccc   3780

tgaggtgcca gcgcggggag tgaggagggg tcagggggct aaggatgcaa cctctgacgt   3840

tctgcgcctt cctaggagag tcttacatgt gttgagattt cacaagcaat gcgagttgta   3900

aaataccagc tctacaagaa gctaggctct gtgacggcat agttttcagt agctttatca   3960

caatattcac aatggagaat tatatgacat ggtagcagaa ataggccctt ttatgtgttg   4020

cttctatttt acctcaaatt gtagatatag ggtaatcaat aaaatccatc catgcctttc   4080

acacactaag t                                                        4091


<210>  4613
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  4613

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile 
        515                 520                 525


Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
545                 550                 555                 560


Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys 
                565                 570                 575


Ser Ser Ser Leu Leu Lys Asn Leu Asn 
            580                 585


<210>  4614
<211>  4183
<212>  DNA
<213>  Homo sapiens

<400>  4614
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgcttaga tttgttgaca gcggtttcct ggagtgctgt   1980

cttgagaacg attctgagga ggctcagcaa gaaagagtgt ttcagttgat tgggtgtgtc   2040

tgtcatggag aaggaactca agctcttgga ctcaccgagg cagtaaaagt accatatcct   2100

gtgtttgaat caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc   2160

cgaagcccta cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa   2220

atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct   2280

agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat   2340

tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc   2400

tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg   2460

agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa   2520

aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg   2580

ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg   2640

ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa   2700

gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc   2760

acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca   2820

tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga   2880

ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg   2940

aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca   3000

attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt caaagccccc   3060

agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc   3120

acggtcatta gaccatttcc aggacttgtg attaataacc agctggttga tcagagtgag   3180

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   3240

gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga ccccacgtgg   3300

tagacctctt ccctcctagg agccttgagt tacggtgttt attttccaat caagtgaaga   3360

tatctcctac ttctcctact ggaacatctc agcttctgca gtgaagaaaa attcctgtga   3420

tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat catttaaatg atcctttgtt   3480

cacggctctc cttaatgact gagtgaacag ttcctatctg tatatttgac taaacctttt   3540

cctaagctat ctctcatggt tcctatgttt ttttatcata attaaaagca aaaccatctg   3600

gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa ttatagagga aatacagaga   3660

gaacctcttc cacttttact tttcgtccaa ataaaatgca tggtgtacca gaagttgaag   3720

atcgggttga ggattggggc tagctcgatg acactaaggc cccaacatcg cgggacctgc   3780

tgtggcgcgg attcttagga acgctgttct agccggcccc ctctccaggg gtcgccgtgg   3840

ccggcattat ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg   3900

ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc ttcctaggag agtcttacat   3960

gtgttgagat ttcacaagca atgcgagttg taaaatacca gctctacaag aagctaggct   4020

ctgtgacggc atagttttca gtagctttat cacaatattc acaatggaga attatatgac   4080

atggtagcag aaataggccc ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat   4140

agggtaatca ataaaatcca tccatgcctt tcacacacta agt                     4183


<210>  4615
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  4615

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
            420                 425                 430


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
        435                 440                 445


Phe Asn Leu Lys Phe Ala 
    450


<210>  4616
<211>  8043
<212>  DNA
<213>  Homo sapiens

<400>  4616
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   2040

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   2100

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2160

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2220

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2280

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2340

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2400

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2460

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2520

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2580

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2640

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2700

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2760

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2820

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2880

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2940

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   3000

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   3060

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3120

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3180

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3240

ttcacggtca ttaggtaagt gagagtttcc tgcttagtca caggagcgaa tctggagctc   3300

atgaggctga ctcttctaaa atgcagccac aggtagtcat cgaatccggc ttcctatgct   3360

gtgcaatcaa caaatcaaaa taacttgtgt catcattaga atgtcagatg tgcttctacg   3420

aactaagctg actcttttaa ttctttggca aagggttggc aaactaggac tgtttgccaa   3480

attcaggctg cctcctattt ttagagtctt cctgaaacac agctacaccc gtattatcca   3540

tggctgcttt cctgtcacag tgagtaagta gctgggactg agaaggcatg gcctccaaag   3600

tctaaaatat ttactctcta gcactttgta gaaaaacctt agctaggcac agtggctaac   3660

gcctgtaatc ccagcatttt gggaggccaa ggcaggcaga tcacctgagg tcaggagttc   3720

cagaccagcc tggccaacat ggtgaaatcc catctctaca aaaataaaac agttagctgg   3780

gcatgatggc gggtgcctgt aatcccagct actcgggagg ctgaggcagg atagtcgctt   3840

gaacccagga ggtggaggtt gcaatgagcc aagatcatgc cactgcactc cagcctggac   3900

gacagagtga gactccatca caagaaaaaa agaactttgt caacctctgt cttagggcgc   3960

cttgtcacag gcttcgggtc agacggattc aaccttgcat cagccatttg ttagccaggt   4020

cactctgttc tttgtctgta aatgagattg atcgttgttc ccactgagag tgtcagctcc   4080

ttcccgtaga gcaggcatga tgattgtact cacctctgac accattgtga gtgccacatt   4140

ccttcccacg tccttgtcac tgtaagagat gcccacctga gcaccaaccc caggttatct   4200

tcccctttgt cttccagccc cccagaaaca gctacgactc aacctaccca atcatttcat   4260

catcagattg ccactgtctc tagttcaggt ctcttgggac tggcactcag aaatctcata   4320

ataaatcctc ttgaggcttc tcatacactc gtcttcttcc aatcttcttt ccctcaaaat   4380

ctcatatttt ggttccactt cacccaccgt cattctccat atcactccca ggagttaggc   4440

aaaaagcccc ttccgttctt ccgtatgtta aacttagaat cactctgttc cctgctctgc   4500

gtttctattt tttgtttttc ctccatttac tagtagctta acactttcta acagtgttct   4560

tattattgat acgtatctat ctcttccata agcttataag gtcacggata atacttctca   4620

ttgtagtacg taaatgacgt gggctagata tgagttgaat aaacagttat acctgtaaat   4680

tcttacagag tgaaaataaa ttgttatact ttacaatttg tttctctctt tagaccattt   4740

ccaggacttg tgattaataa ccgtgagtat tttgtgaagt gttttgtttt tgttttttcc   4800

tggggtctga cgtgtgtgcg tgtgagtgtg tatacatgct taacgtatat cacgttactt   4860

cacctatgtc agtaaccagg ccaaatactt gttttagccc tcagtaaaaa caccaggcac   4920

ttcctagttg taaaattatt caagcttctt aacttcctat cctcgatgca cttaatcata   4980

aaatggtaat aatagcaccg attttggggg agtcgttcca gtagatggaa agcatctgga   5040

acaggtgtca gcaagctcct gccgacgtgt atgcataaag ttttattgaa accaccatcg   5100

tgtccatttg tttatggcag aactgagaga tggcagcagc aagtgtgtgc ctgcaaaacc   5160

taaaatattt actaattggc tctgcaagaa aagagtttgc atccccctaa cctagaacag   5220

tgtctagcct ctagtatgtg tttagcctac agtatgtgct cagcgaatac aatctatatt   5280

tattactgct tttatgactg ttataattac tgtgcttgga tttcgttaca aagtaagtca   5340

caatgtgcct gcttctgtta gtatttcagc acagtgcctg gcacacatgg ggctctcaaa   5400

tattgctgag cgagtgaaca aatgtccttt caattcctta acgttgatgt cattttcaat   5460

agtattttga gccaaactta attttgcgag tgtgttttgt tttcttaact ttattattaa   5520

aaatgtataa aagtgaggcc aggcgtggtg gctcacgcct gtaatcccag cagtttggga   5580

ggctgaggca ggcggatcag ttgaggttgg gagttggaga ccagcccgtc caacatggtg   5640

aaagcctgtc tctactaaaa atacaaaaat cagctgggtg tggtggcgcg tgcctgtaat   5700

cccagctact caggaggctg aggcaggaga gttgcttgaa tcctagaggt ggaggttgca   5760

gtgagctgag atcgtgccat tgcactccag cctgggcaac aagagcaaaa ctctgtccca   5820

ataaataaat aaataaaatg ttctcttttg ttcctgttct tgtgcggtag tgtggtatag   5880

agttttatgg taattactgt gaattagtga ttctgaggga catatcagaa ctctgaggtt   5940

tgtttccttc tcatcttgag ggaaacagca aatgtatgtt aaaatgcttt tccaagggaa   6000

caacacatcc ttacattatt taaaccaatc tgcttcattt tcagagctgg ttgatcagag   6060

tgagtcagaa ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc   6120

cacagaagaa ataaaagaga ctgatggaag ctctcagatc aagcaagaac cagaccccac   6180

gtggtagacc tcttccctcc tagggtaaat cagcttctgt gtcagggatg ctgtgtggtg   6240

tccatctgaa ccccctgcat acgcgtagct aatgtgatct ccccactttc acataagatg   6300

gtggccctgc cttcagggaa tgtgggagcc aggtgggagc cttcccggat atttaagcta   6360

gaagattcta cagggagatt ctccttggat caatatatgt ctctcagtca aagatgtaaa   6420

agcacttttg ccttaaaaag aatgttctgt ttctaaatag agtcaacgtt gtcctcctca   6480

ttggaattca ctatgagtca gaatcattag actgactttt ttttttccat agtaatagta   6540

ttttgcagag tctcacagag ctgcagatct tttgttcatc ttgcagagtt aacaagtctg   6600

atcctgttag tccagatttc ttaaatttgg ccaagttata ataggagcag tagcttgaga   6660

cccgaagtca ggaaactttg acaatggatt ttttttttta atccagagac ttgtactgga   6720

atttgcctta ccctgtcagc tcatggactt aaggtttcat cccgctttat gagtgcttct   6780

gaatccaagt cattgttacc tgaatttgca aattaagttg tgatattcgt gactgttaaa   6840

ttcctgtaat tagattaacc tctttgcttg cttgtttgtt ttctctccta ttttagctta   6900

aagtatcagt ggttgagaag agcttttcgg acctgttact accccaagct gtgtaatata   6960

cttgtataac agaaatacct tctatacaaa cctttttttc tacttttaga tagaaatgtc   7020

tactttttca gcagttctgt gaattaaaga gcagagtgac tgtgggtctg gaatggctgg   7080

tgtacttggg aatgtactat caggatttta cagcaatgct gggaaatgac agggaaaatg   7140

acaggaatga atctcaccag attttttatg tactcagcag agccttgagt tacggtgttt   7200

attttccaat caagtgaaga tatctcctac ttctcctact ggaacatctc agcttctgca   7260

gtgaagaaaa attcctgtga tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat   7320

catttaaatg atcctttgtt cacggctctc cttaatgact gagtgaacag ttcctatctg   7380

tatatttgac taaacctttt cctaagctat ctctcatggt tcctatgttt ttttatcata   7440

attaaaagca aaaccatctg gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa   7500

ttatagagga aatacagaga gaacctcttc cacttttact tttcgtccaa ataaaatgca   7560

tggtgtacca gaagttgaag atcgggttga ggattggggc tagctcgatg acactaaggc   7620

cccaacatcg cgggacctgc tgtggcgcgg attcttagga acgctgttct agccggcccc   7680

ctctccaggg gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac cctgaggtgc   7740

cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc   7800

ttcctaggag agtcttacat gtgttgagat ttcacaagca atgcgagttg taaaatacca   7860

gctctacaag aagctaggct ctgtgacggc atagttttca gtagctttat cacaatattc   7920

acaatggaga attatatgac atggtagcag aaataggccc ttttatgtgt tgcttctatt   7980

ttacctcaaa ttgtagatat agggtaatca ataaaatcca tccatgcctt tcacacacta   8040

agt                                                                 8043


<210>  4617
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  4617

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
465                 470                 475                 480


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
                485                 490                 495


<210>  4618
<211>  7343
<212>  DNA
<213>  Homo sapiens

<400>  4618
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2100

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2160

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2220

tgaatcaaac ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag   2280

ccctacctgg tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa   2340

gttcgttgtt aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa   2400

aataaacact aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa   2460

ggttcctgaa attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc   2520

tgttcgaacc ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga   2580

gttttccttt gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct   2640

cttcaatgag aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc   2700

gttatttgag tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt   2760

ccgaagacca tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa   2820

aattaagttc atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc   2880

ctctaagagc cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg   2940

tgttgaagac cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc   3000

gaaagttgaa aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt   3060

tggtgaagct attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa   3120

ccctggctgt gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta   3180

cctggaaatc agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt   3240

cattaggtaa gtgagagttt cctgcttagt cacaggagcg aatctggagc tcatgaggct   3300

gactcttcta aaatgcagcc acaggtagtc atcgaatccg gcttcctatg ctgtgcaatc   3360

aacaaatcaa aataacttgt gtcatcatta gaatgtcaga tgtgcttcta cgaactaagc   3420

tgactctttt aattctttgg caaagggttg gcaaactagg actgtttgcc aaattcaggc   3480

tgcctcctat ttttagagtc ttcctgaaac acagctacac ccgtattatc catggctgct   3540

ttcctgtcac agtgagtaag tagctgggac tgagaaggca tggcctccaa agtctaaaat   3600

atttactctc tagcactttg tagaaaaacc ttagctaggc acagtggcta acgcctgtaa   3660

tcccagcatt ttgggaggcc aaggcaggca gatcacctga ggtcaggagt tccagaccag   3720

cctggccaac atggtgaaat cccatctcta caaaaataaa acagttagct gggcatgatg   3780

gcgggtgcct gtaatcccag ctactcggga ggctgaggca ggatagtcgc ttgaacccag   3840

gaggtggagg ttgcaatgag ccaagatcat gccactgcac tccagcctgg acgacagagt   3900

gagactccat cacaagaaaa aaagaacttt gtcaacctct gtcttagggc gccttgtcac   3960

aggcttcggg tcagacggat tcaaccttgc atcagccatt tgttagccag gtcactctgt   4020

tctttgtctg taaatgagat tgatcgttgt tcccactgag agtgtcagct ccttcccgta   4080

gagcaggcat gatgattgta ctcacctctg acaccattgt gagtgccaca ttccttccca   4140

cgtccttgtc actgtaagag atgcccacct gagcaccaac cccaggttat cttccccttt   4200

gtcttccagc cccccagaaa cagctacgac tcaacctacc caatcatttc atcatcagat   4260

tgccactgtc tctagttcag gtctcttggg actggcactc agaaatctca taataaatcc   4320

tcttgaggct tctcatacac tcgtcttctt ccaatcttct ttccctcaaa atctcatatt   4380

ttggttccac ttcacccacc gtcattctcc atatcactcc caggagttag gcaaaaagcc   4440

ccttccgttc ttccgtatgt taaacttaga atcactctgt tccctgctct gcgtttctat   4500

tttttgtttt tcctccattt actagtagct taacactttc taacagtgtt cttattattg   4560

atacgtatct atctcttcca taagcttata aggtcacgga taatacttct cattgtagta   4620

cgtaaatgac gtgggctaga tatgagttga ataaacagtt atacctgtaa attcttacag   4680

agtgaaaata aattgttata ctttacaatt tgtttctctc tttagaccat ttccaggact   4740

tgtgattaat aaccgtgagt attttgtgaa gtgttttgtt tttgtttttt cctggggtct   4800

gacgtgtgtg cgtgtgagtg tgtatacatg cttaacgtat atcacgttac ttcacctatg   4860

tcagtaacca ggccaaatac ttgttttagc cctcagtaaa aacaccaggc acttcctagt   4920

tgtaaaatta ttcaagcttc ttaacttcct atcctcgatg cacttaatca taaaatggta   4980

ataatagcac cgattttggg ggagtcgttc cagtagatgg aaagcatctg gaacaggtgt   5040

cagcaagctc ctgccgacgt gtatgcataa agttttattg aaaccaccat cgtgtccatt   5100

tgtttatggc agaactgaga gatggcagca gcaagtgtgt gcctgcaaaa cctaaaatat   5160

ttactaattg gctctgcaag aaaagagttt gcatccccct aacctagaac agtgtctagc   5220

ctctagtatg tgtttagcct acagtatgtg ctcagcgaat acaatctata tttattactg   5280

cttttatgac tgttataatt actgtgcttg gatttcgtta caaagtaagt cacaatgtgc   5340

ctgcttctgt tagtatttca gcacagtgcc tggcacacat ggggctctca aatattgctg   5400

agcgagtgaa caaatgtcct ttcaattcct taacgttgat gtcattttca atagtatttt   5460

gagccaaact taattttgcg agtgtgtttt gttttcttaa ctttattatt aaaaatgtat   5520

aaaagtgagg ccaggcgtgg tggctcacgc ctgtaatccc agcagtttgg gaggctgagg   5580

caggcggatc agttgaggtt gggagttgga gaccagcccg tccaacatgg tgaaagcctg   5640

tctctactaa aaatacaaaa atcagctggg tgtggtggcg cgtgcctgta atcccagcta   5700

ctcaggaggc tgaggcagga gagttgcttg aatcctagag gtggaggttg cagtgagctg   5760

agatcgtgcc attgcactcc agcctgggca acaagagcaa aactctgtcc caataaataa   5820

ataaataaaa tgttctcttt tgttcctgtt cttgtgcggt agtgtggtat agagttttat   5880

ggtaattact gtgaattagt gattctgagg gacatatcag aactctgagg tttgtttcct   5940

tctcatcttg agggaaacag caaatgtatg ttaaaatgct tttccaaggg aacaacacat   6000

ccttacatta tttaaaccaa tctgcttcat tttcagagct ggttgatcag agtgagtcag   6060

aaggccccgt gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag   6120

aaataaaaga gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga   6180

cctcttccct cctaggctta aagtatcagt ggttgagaag agcttttcgg acctgttact   6240

accccaagct gtgtaatata cttgtataac agaaatacct tctatacaaa cctttttttc   6300

tacttttaga tagaaatgtc tactttttca gcagttctgt gaattaaaga gcagagtgac   6360

tgtgggtctg gaatggctgg tgtacttggg aatgtactat caggatttta cagcaatgct   6420

gggaaatgac agggaaaatg acaggaatga atctcaccag attttttatg tactcagcag   6480

agccttgagt tacggtgttt attttccaat caagtgaaga tatctcctac ttctcctact   6540

ggaacatctc agcttctgca gtgaagaaaa attcctgtga tagttcagtt ctttagtttt   6600

tctatttgaa aaaaaaaaat catttaaatg atcctttgtt cacggctctc cttaatgact   6660

gagtgaacag ttcctatctg tatatttgac taaacctttt cctaagctat ctctcatggt   6720

tcctatgttt ttttatcata attaaaagca aaaccatctg gatcacctaa cagtcagagg   6780

tcagtatctc agcgtgtgaa ttatagagga aatacagaga gaacctcttc cacttttact   6840

tttcgtccaa ataaaatgca tggtgtacca gaagttgaag atcgggttga ggattggggc   6900

tagctcgatg acactaaggc cccaacatcg cgggacctgc tgtggcgcgg attcttagga   6960

acgctgttct agccggcccc ctctccaggg gtcgccgtgg ccggcattat ttcctagttc   7020

ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc   7080

aacctctgac gttctgcgcc ttcctaggag agtcttacat gtgttgagat ttcacaagca   7140

atgcgagttg taaaatacca gctctacaag aagctaggct ctgtgacggc atagttttca   7200

gtagctttat cacaatattc acaatggaga attatatgac atggtagcag aaataggccc   7260

ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat agggtaatca ataaaatcca   7320

tccatgcctt tcacacacta agt                                           7343


<210>  4619
<211>  942
<212>  PRT
<213>  Homo sapiens

<400>  4619

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr 
        595                 600                 605


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe 
    610                 615                 620


Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys 
625                 630                 635                 640


Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly 
                645                 650                 655


Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro 
            660                 665                 670


Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val 
        675                 680                 685


Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro 
    690                 695                 700


Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu 
705                 710                 715                 720


Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys 
                725                 730                 735


Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys 
            740                 745                 750


Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp 
        755                 760                 765


Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser 
    770                 775                 780


Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys 
785                 790                 795                 800


Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys 
                805                 810                 815


Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro 
            820                 825                 830


Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln 
        835                 840                 845


Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys 
    850                 855                 860


Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe 
865                 870                 875                 880


Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys 
                885                 890                 895


Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly 
            900                 905                 910


Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg 
        915                 920                 925


Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
    930                 935                 940


<210>  4620
<211>  7760
<212>  DNA
<213>  Homo sapiens

<400>  4620
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagctca agctcttgga ctcaccgagg   1920

cagtaaaagt accatatcct gtgtttgaat caaacccgga gttcttgtat gtggaaggct   1980

tgccagaggg gattcccttc cgaagcccta cctggtttgg aattccacga cttgaaagga   2040

tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa acctgaacta gttatttcct   2100

acttgcctcc tgggatggct agtaaaataa acactaaagc tttgcagtcc cccaaaagac   2160

cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta   2220

ataacaacaa tcctcaaacc tcagctgttc gaaccccgac ccagactaac ggttctaacg   2280

ttcccttcaa gccacgaggg agagagtttt cctttgaggc ctggaatgcc aaaatcacgg   2340

acctaaaaca gaaagttgaa aatctcttca atgagaaatg tggggaagct cttggcctta   2400

aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg   2460

aaggcttacc tgagggtgtg ccattccgaa gaccatcgac ttttggcatt ccgaggctgg   2520

agaagatact cagaaacaaa gccaaaatta agttcatcat taaaaagccc gaaatgtttg   2580

agacggcgat taaggagagc acctcctcta agagccctcc cagaaaaata aattcatcac   2640

ccaatgttaa tactactgca tcaggtgttg aagaccttaa catcattcag gtgacaattc   2700

cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta agagaacaag   2760

tgaatgacct ctttagtcgg aaatttggtg aagctattgg tatgggtttt cctgtgaaag   2820

ttccctacag gaaaatcaca attaaccctg gctgtgtggt ggttgatggc atgcccccgg   2880

gggtgtcctt caaagccccc agctacctgg aaatcagctc catgagaagg atcttagact   2940

ctgccgagtt tatcaaattc acggtcatta ggtaagtgag agtttcctgc ttagtcacag   3000

gagcgaatct ggagctcatg aggctgactc ttctaaaatg cagccacagg tagtcatcga   3060

atccggcttc ctatgctgtg caatcaacaa atcaaaataa cttgtgtcat cattagaatg   3120

tcagatgtgc ttctacgaac taagctgact cttttaattc tttggcaaag ggttggcaaa   3180

ctaggactgt ttgccaaatt caggctgcct cctattttta gagtcttcct gaaacacagc   3240

tacacccgta ttatccatgg ctgctttcct gtcacagtga gtaagtagct gggactgaga   3300

aggcatggcc tccaaagtct aaaatattta ctctctagca ctttgtagaa aaaccttagc   3360

taggcacagt ggctaacgcc tgtaatccca gcattttggg aggccaaggc aggcagatca   3420

cctgaggtca ggagttccag accagcctgg ccaacatggt gaaatcccat ctctacaaaa   3480

ataaaacagt tagctgggca tgatggcggg tgcctgtaat cccagctact cgggaggctg   3540

aggcaggata gtcgcttgaa cccaggaggt ggaggttgca atgagccaag atcatgccac   3600

tgcactccag cctggacgac agagtgagac tccatcacaa gaaaaaaaga actttgtcaa   3660

cctctgtctt agggcgcctt gtcacaggct tcgggtcaga cggattcaac cttgcatcag   3720

ccatttgtta gccaggtcac tctgttcttt gtctgtaaat gagattgatc gttgttccca   3780

ctgagagtgt cagctccttc ccgtagagca ggcatgatga ttgtactcac ctctgacacc   3840

attgtgagtg ccacattcct tcccacgtcc ttgtcactgt aagagatgcc cacctgagca   3900

ccaaccccag gttatcttcc cctttgtctt ccagcccccc agaaacagct acgactcaac   3960

ctacccaatc atttcatcat cagattgcca ctgtctctag ttcaggtctc ttgggactgg   4020

cactcagaaa tctcataata aatcctcttg aggcttctca tacactcgtc ttcttccaat   4080

cttctttccc tcaaaatctc atattttggt tccacttcac ccaccgtcat tctccatatc   4140

actcccagga gttaggcaaa aagccccttc cgttcttccg tatgttaaac ttagaatcac   4200

tctgttccct gctctgcgtt tctatttttt gtttttcctc catttactag tagcttaaca   4260

ctttctaaca gtgttcttat tattgatacg tatctatctc ttccataagc ttataaggtc   4320

acggataata cttctcattg tagtacgtaa atgacgtggg ctagatatga gttgaataaa   4380

cagttatacc tgtaaattct tacagagtga aaataaattg ttatacttta caatttgttt   4440

ctctctttag accatttcca ggacttgtga ttaataaccg tgagtatttt gtgaagtgtt   4500

ttgtttttgt tttttcctgg ggtctgacgt gtgtgcgtgt gagtgtgtat acatgcttaa   4560

cgtatatcac gttacttcac ctatgtcagt aaccaggcca aatacttgtt ttagccctca   4620

gtaaaaacac caggcacttc ctagttgtaa aattattcaa gcttcttaac ttcctatcct   4680

cgatgcactt aatcataaaa tggtaataat agcaccgatt ttgggggagt cgttccagta   4740

gatggaaagc atctggaaca ggtgtcagca agctcctgcc gacgtgtatg cataaagttt   4800

tattgaaacc accatcgtgt ccatttgttt atggcagaac tgagagatgg cagcagcaag   4860

tgtgtgcctg caaaacctaa aatatttact aattggctct gcaagaaaag agtttgcatc   4920

cccctaacct agaacagtgt ctagcctcta gtatgtgttt agcctacagt atgtgctcag   4980

cgaatacaat ctatatttat tactgctttt atgactgtta taattactgt gcttggattt   5040

cgttacaaag taagtcacaa tgtgcctgct tctgttagta tttcagcaca gtgcctggca   5100

cacatggggc tctcaaatat tgctgagcga gtgaacaaat gtcctttcaa ttccttaacg   5160

ttgatgtcat tttcaatagt attttgagcc aaacttaatt ttgcgagtgt gttttgtttt   5220

cttaacttta ttattaaaaa tgtataaaag tgaggccagg cgtggtggct cacgcctgta   5280

atcccagcag tttgggaggc tgaggcaggc ggatcagttg aggttgggag ttggagacca   5340

gcccgtccaa catggtgaaa gcctgtctct actaaaaata caaaaatcag ctgggtgtgg   5400

tggcgcgtgc ctgtaatccc agctactcag gaggctgagg caggagagtt gcttgaatcc   5460

tagaggtgga ggttgcagtg agctgagatc gtgccattgc actccagcct gggcaacaag   5520

agcaaaactc tgtcccaata aataaataaa taaaatgttc tcttttgttc ctgttcttgt   5580

gcggtagtgt ggtatagagt tttatggtaa ttactgtgaa ttagtgattc tgagggacat   5640

atcagaactc tgaggtttgt ttccttctca tcttgaggga aacagcaaat gtatgttaaa   5700

atgcttttcc aagggaacaa cacatcctta cattatttaa accaatctgc ttcattttca   5760

gagctggttg atcagagtga gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc   5820

cagttggaag ttccagccac agaagaaata aaagagactg atggaagctc tcagatcaag   5880

caagaaccag accccacgtg gtagacctct tccctcctag ggtaaatcag cttctgtgtc   5940

agggatgctg tgtggtgtcc atctgaaccc cctgcatacg cgtagctaat gtgatctccc   6000

cactttcaca taagatggtg gccctgcctt cagggaatgt gggagccagg tgggagcctt   6060

cccggatatt taagctagaa gattctacag ggagattctc cttggatcaa tatatgtctc   6120

tcagtcaaag atgtaaaagc acttttgcct taaaaagaat gttctgtttc taaatagagt   6180

caacgttgtc ctcctcattg gaattcacta tgagtcagaa tcattagact gacttttttt   6240

tttccatagt aatagtattt tgcagagtct cacagagctg cagatctttt gttcatcttg   6300

cagagttaac aagtctgatc ctgttagtcc agatttctta aatttggcca agttataata   6360

ggagcagtag cttgagaccc gaagtcagga aactttgaca atggattttt ttttttaatc   6420

cagagacttg tactggaatt tgccttaccc tgtcagctca tggacttaag gtttcatccc   6480

gctttatgag tgcttctgaa tccaagtcat tgttacctga atttgcaaat taagttgtga   6540

tattcgtgac tgttaaattc ctgtaattag attaacctct ttgcttgctt gtttgttttc   6600

tctcctattt tagcttaaag tatcagtggt tgagaagagc ttttcggacc tgttactacc   6660

ccaagctgtg taatatactt gtataacaga aataccttct atacaaacct ttttttctac   6720

ttttagatag aaatgtctac tttttcagca gttctgtgaa ttaaagagca gagtgactgt   6780

gggtctggaa tggctggtgt acttgggaat gtactatcag gattttacag caatgctggg   6840

aaatgacagg gaaaatgaca ggaatgaatc tcaccagatt ttttatgtac tcagcagagc   6900

cttgagttac ggtgtttatt ttccaatcaa gtgaagatat ctcctacttc tcctactgga   6960

acatctcagc ttctgcagtg aagaaaaatt cctgtgatag ttcagttctt tagtttttct   7020

atttgaaaaa aaaaaatcat ttaaatgatc ctttgttcac ggctctcctt aatgactgag   7080

tgaacagttc ctatctgtat atttgactaa accttttcct aagctatctc tcatggttcc   7140

tatgtttttt tatcataatt aaaagcaaaa ccatctggat cacctaacag tcagaggtca   7200

gtatctcagc gtgtgaatta tagaggaaat acagagagaa cctcttccac ttttactttt   7260

cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc gggttgagga ttggggctag   7320

ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg   7380

ctgttctagc cggccccctc tccaggggtc gccgtggccg gcattatttc ctagttcttc   7440

ttgtaaccct gaggtgccag cgcggggagt gaggaggggt cagggggcta aggatgcaac   7500

ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg ttgagatttc acaagcaatg   7560

cgagttgtaa aataccagct ctacaagaag ctaggctctg tgacggcata gttttcagta   7620

gctttatcac aatattcaca atggagaatt atatgacatg gtagcagaaa taggcccttt   7680

tatgtgttgc ttctatttta cctcaaattg tagatatagg gtaatcaata aaatccatcc   7740

atgcctttca cacactaagt                                               7760


<210>  4621
<211>  857
<212>  PRT
<213>  Homo sapiens

<400>  4621

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
            500                 505                 510


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
        515                 520                 525


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
    530                 535                 540


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
545                 550                 555                 560


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
                565                 570                 575


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
            580                 585                 590


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
        595                 600                 605


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
    610                 615                 620


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
625                 630                 635                 640


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
                645                 650                 655


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
            660                 665                 670


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
        675                 680                 685


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
    690                 695                 700


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
705                 710                 715                 720


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
                725                 730                 735


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
            740                 745                 750


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
        755                 760                 765


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
    770                 775                 780


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
785                 790                 795                 800


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
                805                 810                 815


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
            820                 825                 830


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
        835                 840                 845


Glu Phe Ile Lys Phe Thr Val Ile Arg 
    850                 855


<210>  4622
<211>  5142
<212>  DNA
<213>  Homo sapiens

<400>  4622
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagc   2040

tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc   2100

ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc ctacctggtt   2160

tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa   2220

aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa taaacactaa   2280

agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg ttcctgaaat   2340

tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg ttcgaacccc   2400

gacccagact aacggttcta acgttccctt caagccacga gggagagagt tttcctttga   2460

ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct tcaatgagaa   2520

atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc   2580

tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc gaagaccatc   2640

gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa ttaagttcat   2700

cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct ctaagagccc   2760

tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg ttgaagacct   2820

taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga aagttgaaaa   2880

agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg gtgaagctat   2940

tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc ctggctgtgt   3000

ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc tggaaatcag   3060

ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca ttagaccatt   3120

tccaggactt gtgattaata accagctggt tgatcagagt gagtcagaag gccccgtgat   3180

acaagaatca gctgaaccaa gccagttgga agttccagcc acagaagaaa taaaagagac   3240

tgatggaagc tctcagatca agcaagaacc agaccccacg tggtagacct cttccctcct   3300

agggtaaatc agcttctgtg tcagggatgc tgtgtggtgt ccatctgaac cccctgcata   3360

cgcgtagcta atgtgatctc cccactttca cataagatgg tggccctgcc ttcagggaat   3420

gtgggagcca ggtgggagcc ttcccggata tttaagctag aagattctac agggagattc   3480

tccttggatc aatatatgtc tctcagtcaa agatgtaaaa gcacttttgc cttaaaaaga   3540

atgttctgtt tctaaataga gtcaacgttg tcctcctcat tggaattcac tatgagtcag   3600

aatcattaga ctgacttttt tttttccata gtaatagtat tttgcagagt ctcacagagc   3660

tgcagatctt ttgttcatct tgcagagtta acaagtctga tcctgttagt ccagatttct   3720

taaatttggc caagttataa taggagcagt agcttgagac ccgaagtcag gaaactttga   3780

caatggattt ttttttttaa tccagagact tgtactggaa tttgccttac cctgtcagct   3840

catggactta aggtttcatc ccgctttatg agtgcttctg aatccaagtc attgttacct   3900

gaatttgcaa attaagttgt gatattcgtg actgttaaat tcctgtaatt agattaacct   3960

ctttgcttgc ttgtttgttt tctctcctat tttagcttaa agtatcagtg gttgagaaga   4020

gcttttcgga cctgttacta ccccaagctg tgtaatatac ttgtataaca gaaatacctt   4080

ctatacaaac ctttttttct acttttagat agaaatgtct actttttcag cagttctgtg   4140

aattaaagag cagagtgact gtgggtctgg aatggctggt gtacttggga atgtactatc   4200

aggattttac agcaatgctg ggaaatgaca gggaaaatga caggaatgaa tctcaccaga   4260

ttttttatgt actcagcaga gccttgagtt acggtgttta ttttccaatc aagtgaagat   4320

atctcctact tctcctactg gaacatctca gcttctgcag tgaagaaaaa ttcctgtgat   4380

agttcagttc tttagttttt ctatttgaaa aaaaaaaatc atttaaatga tcctttgttc   4440

acggctctcc ttaatgactg agtgaacagt tcctatctgt atatttgact aaaccttttc   4500

ctaagctatc tctcatggtt cctatgtttt tttatcataa ttaaaagcaa aaccatctgg   4560

atcacctaac agtcagaggt cagtatctca gcgtgtgaat tatagaggaa atacagagag   4620

aacctcttcc acttttactt ttcgtccaaa taaaatgcat ggtgtaccag aagttgaaga   4680

tcgggttgag gattggggct agctcgatga cactaaggcc ccaacatcgc gggacctgct   4740

gtggcgcgga ttcttaggaa cgctgttcta gccggccccc tctccagggg tcgccgtggc   4800

cggcattatt tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga gtgaggaggg   4860

gtcagggggc taaggatgca acctctgacg ttctgcgcct tcctaggaga gtcttacatg   4920

tgttgagatt tcacaagcaa tgcgagttgt aaaataccag ctctacaaga agctaggctc   4980

tgtgacggca tagttttcag tagctttatc acaatattca caatggagaa ttatatgaca   5040

tggtagcaga aataggccct tttatgtgtt gcttctattt tacctcaaat tgtagatata   5100

gggtaatcaa taaaatccat ccatgccttt cacacactaa gt                      5142


<210>  4623
<211>  954
<212>  PRT
<213>  Homo sapiens

<400>  4623

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly 
    530                 535                 540


Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro 
545                 550                 555                 560


Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser 
                565                 570                 575


Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser 
            580                 585                 590


Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr 
        595                 600                 605


Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser 
    610                 615                 620


Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile 
625                 630                 635                 640


Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala 
                645                 650                 655


Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro 
            660                 665                 670


Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp 
        675                 680                 685


Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala 
    690                 695                 700


Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser 
705                 710                 715                 720


Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe 
                725                 730                 735


Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg 
            740                 745                 750


Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu 
        755                 760                 765


Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile 
    770                 775                 780


Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu 
785                 790                 795                 800


Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser 
                805                 810                 815


Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe 
            820                 825                 830


Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val 
        835                 840                 845


Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly 
    850                 855                 860


Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser 
865                 870                 875                 880


Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val 
                885                 890                 895


Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln 
            900                 905                 910


Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln 
        915                 920                 925


Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser 
    930                 935                 940


Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  4624
<211>  7200
<212>  DNA
<213>  Homo sapiens

<400>  4624
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1980

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   2040

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttgt   2100

atgtggaagg cttgccagag gggattccct tccgaagccc tacctggttt ggaattccac   2160

gacttgaaag gatcgtccgc gggagtaata aaatcaagtt cgttgttaaa aaacctgaac   2220

tagttatttc ctacttgcct cctgggatgg ctagtaaaat aaacactaaa gctttgcagt   2280

cccccaaaag accacgaagt cctgggagta attcaaaggt tcctgaaatt gaggtcaccg   2340

tggaaggccc taataacaac aatcctcaaa cctcagctgt tcgaaccccg acccagacta   2400

acggttctaa cgttcccttc aagccacgag ggagagagtt ttcctttgag gcctggaatg   2460

ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt caatgagaaa tgtggggaag   2520

ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt atttgagtct ttcccggaag   2580

acttttatgt ggaaggctta cctgagggtg tgccattccg aagaccatcg acttttggca   2640

ttccgaggct ggagaagata ctcagaaaca aagccaaaat taagttcatc attaaaaagc   2700

ccgaaatgtt tgagacggcg attaaggaga gcacctcctc taagagccct cccagaaaaa   2760

taaattcatc acccaatgtt aatactactg catcaggtgt tgaagacctt aacatcattc   2820

aggtgacaat tccagatgat gataatgaaa gactctcgaa agttgaaaaa gctagacagc   2880

taagagaaca agtgaatgac ctctttagtc ggaaatttgg tgaagctatt ggtatgggtt   2940

ttcctgtgaa agttccctac aggaaaatca caattaaccc tggctgtgtg gtggttgatg   3000

gcatgccccc gggggtgtcc ttcaaagccc ccagctacct ggaaatcagc tccatgagaa   3060

ggatcttaga ctctgccgag tttatcaaat tcacggtcat taggtaagtg agagtttcct   3120

gcttagtcac aggagcgaat ctggagctca tgaggctgac tcttctaaaa tgcagccaca   3180

ggtagtcatc gaatccggct tcctatgctg tgcaatcaac aaatcaaaat aacttgtgtc   3240

atcattagaa tgtcagatgt gcttctacga actaagctga ctcttttaat tctttggcaa   3300

agggttggca aactaggact gtttgccaaa ttcaggctgc ctcctatttt tagagtcttc   3360

ctgaaacaca gctacacccg tattatccat ggctgctttc ctgtcacagt gagtaagtag   3420

ctgggactga gaaggcatgg cctccaaagt ctaaaatatt tactctctag cactttgtag   3480

aaaaacctta gctaggcaca gtggctaacg cctgtaatcc cagcattttg ggaggccaag   3540

gcaggcagat cacctgaggt caggagttcc agaccagcct ggccaacatg gtgaaatccc   3600

atctctacaa aaataaaaca gttagctggg catgatggcg ggtgcctgta atcccagcta   3660

ctcgggaggc tgaggcagga tagtcgcttg aacccaggag gtggaggttg caatgagcca   3720

agatcatgcc actgcactcc agcctggacg acagagtgag actccatcac aagaaaaaaa   3780

gaactttgtc aacctctgtc ttagggcgcc ttgtcacagg cttcgggtca gacggattca   3840

accttgcatc agccatttgt tagccaggtc actctgttct ttgtctgtaa atgagattga   3900

tcgttgttcc cactgagagt gtcagctcct tcccgtagag caggcatgat gattgtactc   3960

acctctgaca ccattgtgag tgccacattc cttcccacgt ccttgtcact gtaagagatg   4020

cccacctgag caccaacccc aggttatctt cccctttgtc ttccagcccc ccagaaacag   4080

ctacgactca acctacccaa tcatttcatc atcagattgc cactgtctct agttcaggtc   4140

tcttgggact ggcactcaga aatctcataa taaatcctct tgaggcttct catacactcg   4200

tcttcttcca atcttctttc cctcaaaatc tcatattttg gttccacttc acccaccgtc   4260

attctccata tcactcccag gagttaggca aaaagcccct tccgttcttc cgtatgttaa   4320

acttagaatc actctgttcc ctgctctgcg tttctatttt ttgtttttcc tccatttact   4380

agtagcttaa cactttctaa cagtgttctt attattgata cgtatctatc tcttccataa   4440

gcttataagg tcacggataa tacttctcat tgtagtacgt aaatgacgtg ggctagatat   4500

gagttgaata aacagttata cctgtaaatt cttacagagt gaaaataaat tgttatactt   4560

tacaatttgt ttctctcttt agaccatttc caggacttgt gattaataac cgtgagtatt   4620

ttgtgaagtg ttttgttttt gttttttcct ggggtctgac gtgtgtgcgt gtgagtgtgt   4680

atacatgctt aacgtatatc acgttacttc acctatgtca gtaaccaggc caaatacttg   4740

ttttagccct cagtaaaaac accaggcact tcctagttgt aaaattattc aagcttctta   4800

acttcctatc ctcgatgcac ttaatcataa aatggtaata atagcaccga ttttggggga   4860

gtcgttccag tagatggaaa gcatctggaa caggtgtcag caagctcctg ccgacgtgta   4920

tgcataaagt tttattgaaa ccaccatcgt gtccatttgt ttatggcaga actgagagat   4980

ggcagcagca agtgtgtgcc tgcaaaacct aaaatattta ctaattggct ctgcaagaaa   5040

agagtttgca tccccctaac ctagaacagt gtctagcctc tagtatgtgt ttagcctaca   5100

gtatgtgctc agcgaataca atctatattt attactgctt ttatgactgt tataattact   5160

gtgcttggat ttcgttacaa agtaagtcac aatgtgcctg cttctgttag tatttcagca   5220

cagtgcctgg cacacatggg gctctcaaat attgctgagc gagtgaacaa atgtcctttc   5280

aattccttaa cgttgatgtc attttcaata gtattttgag ccaaacttaa ttttgcgagt   5340

gtgttttgtt ttcttaactt tattattaaa aatgtataaa agtgaggcca ggcgtggtgg   5400

ctcacgcctg taatcccagc agtttgggag gctgaggcag gcggatcagt tgaggttggg   5460

agttggagac cagcccgtcc aacatggtga aagcctgtct ctactaaaaa tacaaaaatc   5520

agctgggtgt ggtggcgcgt gcctgtaatc ccagctactc aggaggctga ggcaggagag   5580

ttgcttgaat cctagaggtg gaggttgcag tgagctgaga tcgtgccatt gcactccagc   5640

ctgggcaaca agagcaaaac tctgtcccaa taaataaata aataaaatgt tctcttttgt   5700

tcctgttctt gtgcggtagt gtggtataga gttttatggt aattactgtg aattagtgat   5760

tctgagggac atatcagaac tctgaggttt gtttccttct catcttgagg gaaacagcaa   5820

atgtatgtta aaatgctttt ccaagggaac aacacatcct tacattattt aaaccaatct   5880

gcttcatttt cagagctggt tgatcagagt gagtcagaag gccccgtgat acaagaatca   5940

gctgaaccaa gccagttgga agttccagcc acagaagaaa taaaagagac tgatggaagc   6000

tctcagatca agcaagaacc agaccccacg tggtagacct cttccctcct aggcttaaag   6060

tatcagtggt tgagaagagc ttttcggacc tgttactacc ccaagctgtg taatatactt   6120

gtataacaga aataccttct atacaaacct ttttttctac ttttagatag aaatgtctac   6180

tttttcagca gttctgtgaa ttaaagagca gagtgactgt gggtctggaa tggctggtgt   6240

acttgggaat gtactatcag gattttacag caatgctggg aaatgacagg gaaaatgaca   6300

ggaatgaatc tcaccagatt ttttatgtac tcagcagagc cttgagttac ggtgtttatt   6360

ttccaatcaa gtgaagatat ctcctacttc tcctactgga acatctcagc ttctgcagtg   6420

aagaaaaatt cctgtgatag ttcagttctt tagtttttct atttgaaaaa aaaaaatcat   6480

ttaaatgatc ctttgttcac ggctctcctt aatgactgag tgaacagttc ctatctgtat   6540

atttgactaa accttttcct aagctatctc tcatggttcc tatgtttttt tatcataatt   6600

aaaagcaaaa ccatctggat cacctaacag tcagaggtca gtatctcagc gtgtgaatta   6660

tagaggaaat acagagagaa cctcttccac ttttactttt cgtccaaata aaatgcatgg   6720

tgtaccagaa gttgaagatc gggttgagga ttggggctag ctcgatgaca ctaaggcccc   6780

aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg ctgttctagc cggccccctc   6840

tccaggggtc gccgtggccg gcattatttc ctagttcttc ttgtaaccct gaggtgccag   6900

cgcggggagt gaggaggggt cagggggcta aggatgcaac ctctgacgtt ctgcgccttc   6960

ctaggagagt cttacatgtg ttgagatttc acaagcaatg cgagttgtaa aataccagct   7020

ctacaagaag ctaggctctg tgacggcata gttttcagta gctttatcac aatattcaca   7080

atggagaatt atatgacatg gtagcagaaa taggcccttt tatgtgttgc ttctatttta   7140

cctcaaattg tagatatagg gtaatcaata aaatccatcc atgcctttca cacactaagt   7200


<210>  4625
<211>  901
<212>  PRT
<213>  Homo sapiens

<400>  4625

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
                565                 570                 575


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
            580                 585                 590


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
        595                 600                 605


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
    610                 615                 620


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
625                 630                 635                 640


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
                645                 650                 655


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
            660                 665                 670


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
        675                 680                 685


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
    690                 695                 700


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
705                 710                 715                 720


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
                725                 730                 735


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
            740                 745                 750


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
        755                 760                 765


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
    770                 775                 780


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
785                 790                 795                 800


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
                805                 810                 815


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
            820                 825                 830


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
        835                 840                 845


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
    850                 855                 860


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
865                 870                 875                 880


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
                885                 890                 895


Phe Thr Val Ile Arg 
            900


<210>  4626
<211>  5168
<212>  DNA
<213>  Homo sapiens

<400>  4626
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1980

aagagatttt taatttgaaa tttgcttaga tttgttgaca gcggtttcct ggagtgctgt   2040

cttgagaacg attctgagga ggctcagcaa gaaagagtgt ttcagttgat tgggtgtgtc   2100

tgtcatggag aaggaactca agctcttgga ctcaccgagg cagtaaaagt accatatcct   2160

gtgtttgaat caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc   2220

cgaagcccta cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa   2280

atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct   2340

agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat   2400

tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc   2460

tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg   2520

agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa   2580

aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg   2640

ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg   2700

ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa   2760

gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc   2820

acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca   2880

tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga   2940

ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg   3000

aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca   3060

attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt caaagccccc   3120

agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc   3180

acggtcatta gaccatttcc aggacttgtg attaataacc agctggttga tcagagtgag   3240

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   3300

gaaggtaaaa ggacctcttc cctcctaggg taaatcagct tctgtgtcag ggatgctgtg   3360

tggtgtccat ctgaaccccc tgcatacgcg tagctaatgt gatctcccca ctttcacata   3420

agatggtggc cctgccttca gggaatgtgg gagccaggtg ggagccttcc cggatattta   3480

agctagaaga ttctacaggg agattctcct tggatcaata tatgtctctc agtcaaagat   3540

gtaaaagcac ttttgcctta aaaagaatgt tctgtttcta aatagagtca acgttgtcct   3600

cctcattgga attcactatg agtcagaatc attagactga cttttttttt tccatagtaa   3660

tagtattttg cagagtctca cagagctgca gatcttttgt tcatcttgca gagttaacaa   3720

gtctgatcct gttagtccag atttcttaaa tttggccaag ttataatagg agcagtagct   3780

tgagacccga agtcaggaaa ctttgacaat ggattttttt ttttaatcca gagacttgta   3840

ctggaatttg ccttaccctg tcagctcatg gacttaaggt ttcatcccgc tttatgagtg   3900

cttctgaatc caagtcattg ttacctgaat ttgcaaatta agttgtgata ttcgtgactg   3960

ttaaattcct gtaattagat taacctcttt gcttgcttgt ttgttttctc tcctatttta   4020

gcttaaagta tcagtggttg agaagagctt ttcggacctg ttactacccc aagctgtgta   4080

atatacttgt ataacagaaa taccttctat acaaaccttt ttttctactt ttagatagaa   4140

atgtctactt tttcagcagt tctgtgaatt aaagagcaga gtgactgtgg gtctggaatg   4200

gctggtgtac ttgggaatgt actatcagga ttttacagca atgctgggaa atgacaggga   4260

aaatgacagg aatgaatctc accagatttt ttatgtactc agcagagcct tgagttacgg   4320

tgtttatttt ccaatcaagt gaagatatct cctacttctc ctactggaac atctcagctt   4380

ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa   4440

aaaatcattt aaatgatcct ttgttcacgg ctctccttaa tgactgagtg aacagttcct   4500

atctgtatat ttgactaaac cttttcctaa gctatctctc atggttccta tgttttttta   4560

tcataattaa aagcaaaacc atctggatca cctaacagtc agaggtcagt atctcagcgt   4620

gtgaattata gaggaaatac agagagaacc tcttccactt ttacttttcg tccaaataaa   4680

atgcatggtg taccagaagt tgaagatcgg gttgaggatt ggggctagct cgatgacact   4740

aaggccccaa catcgcggga cctgctgtgg cgcggattct taggaacgct gttctagccg   4800

gccccctctc caggggtcgc cgtggccggc attatttcct agttcttctt gtaaccctga   4860

ggtgccagcg cggggagtga ggaggggtca gggggctaag gatgcaacct ctgacgttct   4920

gcgccttcct aggagagtct tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa   4980

taccagctct acaagaagct aggctctgtg acggcatagt tttcagtagc tttatcacaa   5040

tattcacaat ggagaattat atgacatggt agcagaaata ggccctttta tgtgttgctt   5100

ctattttacc tcaaattgta gatatagggt aatcaataaa atccatccat gcctttcaca   5160

cactaagt                                                            5168


<210>  4627
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  4627

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
    450                 455                 460


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
465                 470


<210>  4628
<211>  7375
<212>  DNA
<213>  Homo sapiens

<400>  4628
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   2040

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gcttagattt   2100

gttgacagcg gtttcctgga gtgctgtctt gagaacgatt ctgaggaggc tcagcaagaa   2160

agagtgtttc agttgattgg gtgtgtctgt catggagaag gaactcaagc tcttggactc   2220

accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgtatgtg   2280

gaaggcttgc cagaggggat tcccttccga agccctacct ggtttggaat tccacgactt   2340

gaaaggatcg tccgcgggag taataaaatc aagttcgttg ttaaaaaacc tgaactagtt   2400

atttcctact tgcctcctgg gatggctagt aaaataaaca ctaaagcttt gcagtccccc   2460

aaaagaccac gaagtcctgg gagtaattca aaggttcctg aaattgaggt caccgtggaa   2520

ggccctaata acaacaatcc tcaaacctca gctgttcgaa ccccgaccca gactaacggt   2580

tctaacgttc ccttcaagcc acgagggaga gagttttcct ttgaggcctg gaatgccaaa   2640

atcacggacc taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg ggaagctctt   2700

ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg agtctttccc ggaagacttt   2760

tatgtggaag gcttacctga gggtgtgcca ttccgaagac catcgacttt tggcattccg   2820

aggctggaga agatactcag aaacaaagcc aaaattaagt tcatcattaa aaagcccgaa   2880

atgtttgaga cggcgattaa ggagagcacc tcctctaaga gccctcccag aaaaataaat   2940

tcatcaccca atgttaatac tactgcatca ggtgttgaag accttaacat cattcaggtg   3000

acaattccag atgatgataa tgaaagactc tcgaaagttg aaaaagctag acagctaaga   3060

gaacaagtga atgacctctt tagtcggaaa tttggtgaag ctattggtat gggttttcct   3120

gtgaaagttc cctacaggaa aatcacaatt aaccctggct gtgtggtggt tgatggcatg   3180

cccccggggg tgtccttcaa agcccccagc tacctggaaa tcagctccat gagaaggatc   3240

ttagactctg ccgagtttat caaattcacg gtcattaggt aagtgagagt ttcctgctta   3300

gtcacaggag cgaatctgga gctcatgagg ctgactcttc taaaatgcag ccacaggtag   3360

tcatcgaatc cggcttccta tgctgtgcaa tcaacaaatc aaaataactt gtgtcatcat   3420

tagaatgtca gatgtgcttc tacgaactaa gctgactctt ttaattcttt ggcaaagggt   3480

tggcaaacta ggactgtttg ccaaattcag gctgcctcct atttttagag tcttcctgaa   3540

acacagctac acccgtatta tccatggctg ctttcctgtc acagtgagta agtagctggg   3600

actgagaagg catggcctcc aaagtctaaa atatttactc tctagcactt tgtagaaaaa   3660

ccttagctag gcacagtggc taacgcctgt aatcccagca ttttgggagg ccaaggcagg   3720

cagatcacct gaggtcagga gttccagacc agcctggcca acatggtgaa atcccatctc   3780

tacaaaaata aaacagttag ctgggcatga tggcgggtgc ctgtaatccc agctactcgg   3840

gaggctgagg caggatagtc gcttgaaccc aggaggtgga ggttgcaatg agccaagatc   3900

atgccactgc actccagcct ggacgacaga gtgagactcc atcacaagaa aaaaagaact   3960

ttgtcaacct ctgtcttagg gcgccttgtc acaggcttcg ggtcagacgg attcaacctt   4020

gcatcagcca tttgttagcc aggtcactct gttctttgtc tgtaaatgag attgatcgtt   4080

gttcccactg agagtgtcag ctccttcccg tagagcaggc atgatgattg tactcacctc   4140

tgacaccatt gtgagtgcca cattccttcc cacgtccttg tcactgtaag agatgcccac   4200

ctgagcacca accccaggtt atcttcccct ttgtcttcca gccccccaga aacagctacg   4260

actcaaccta cccaatcatt tcatcatcag attgccactg tctctagttc aggtctcttg   4320

ggactggcac tcagaaatct cataataaat cctcttgagg cttctcatac actcgtcttc   4380

ttccaatctt ctttccctca aaatctcata ttttggttcc acttcaccca ccgtcattct   4440

ccatatcact cccaggagtt aggcaaaaag ccccttccgt tcttccgtat gttaaactta   4500

gaatcactct gttccctgct ctgcgtttct attttttgtt tttcctccat ttactagtag   4560

cttaacactt tctaacagtg ttcttattat tgatacgtat ctatctcttc cataagctta   4620

taaggtcacg gataatactt ctcattgtag tacgtaaatg acgtgggcta gatatgagtt   4680

gaataaacag ttatacctgt aaattcttac agagtgaaaa taaattgtta tactttacaa   4740

tttgtttctc tctttagacc atttccagga cttgtgatta ataaccgtga gtattttgtg   4800

aagtgttttg tttttgtttt ttcctggggt ctgacgtgtg tgcgtgtgag tgtgtataca   4860

tgcttaacgt atatcacgtt acttcaccta tgtcagtaac caggccaaat acttgtttta   4920

gccctcagta aaaacaccag gcacttccta gttgtaaaat tattcaagct tcttaacttc   4980

ctatcctcga tgcacttaat cataaaatgg taataatagc accgattttg ggggagtcgt   5040

tccagtagat ggaaagcatc tggaacaggt gtcagcaagc tcctgccgac gtgtatgcat   5100

aaagttttat tgaaaccacc atcgtgtcca tttgtttatg gcagaactga gagatggcag   5160

cagcaagtgt gtgcctgcaa aacctaaaat atttactaat tggctctgca agaaaagagt   5220

ttgcatcccc ctaacctaga acagtgtcta gcctctagta tgtgtttagc ctacagtatg   5280

tgctcagcga atacaatcta tatttattac tgcttttatg actgttataa ttactgtgct   5340

tggatttcgt tacaaagtaa gtcacaatgt gcctgcttct gttagtattt cagcacagtg   5400

cctggcacac atggggctct caaatattgc tgagcgagtg aacaaatgtc ctttcaattc   5460

cttaacgttg atgtcatttt caatagtatt ttgagccaaa cttaattttg cgagtgtgtt   5520

ttgttttctt aactttatta ttaaaaatgt ataaaagtga ggccaggcgt ggtggctcac   5580

gcctgtaatc ccagcagttt gggaggctga ggcaggcgga tcagttgagg ttgggagttg   5640

gagaccagcc cgtccaacat ggtgaaagcc tgtctctact aaaaatacaa aaatcagctg   5700

ggtgtggtgg cgcgtgcctg taatcccagc tactcaggag gctgaggcag gagagttgct   5760

tgaatcctag aggtggaggt tgcagtgagc tgagatcgtg ccattgcact ccagcctggg   5820

caacaagagc aaaactctgt cccaataaat aaataaataa aatgttctct tttgttcctg   5880

ttcttgtgcg gtagtgtggt atagagtttt atggtaatta ctgtgaatta gtgattctga   5940

gggacatatc agaactctga ggtttgtttc cttctcatct tgagggaaac agcaaatgta   6000

tgttaaaatg cttttccaag ggaacaacac atccttacat tatttaaacc aatctgcttc   6060

attttcagag ctggttgatc agagtgagtc agaaggcccc gtgatacaag aatcagctga   6120

accaagccag ttggaagttc cagccacaga agaaataaaa gagactgatg gaagctctca   6180

gatcaagcaa gaaccagacc ccacgtggta gacctcttcc ctcctaggct taaagtatca   6240

gtggttgaga agagcttttc ggacctgtta ctaccccaag ctgtgtaata tacttgtata   6300

acagaaatac cttctataca aacctttttt tctactttta gatagaaatg tctacttttt   6360

cagcagttct gtgaattaaa gagcagagtg actgtgggtc tggaatggct ggtgtacttg   6420

ggaatgtact atcaggattt tacagcaatg ctgggaaatg acagggaaaa tgacaggaat   6480

gaatctcacc agatttttta tgtactcagc agagccttga gttacggtgt ttattttcca   6540

atcaagtgaa gatatctcct acttctccta ctggaacatc tcagcttctg cagtgaagaa   6600

aaattcctgt gatagttcag ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa   6660

tgatcctttg ttcacggctc tccttaatga ctgagtgaac agttcctatc tgtatatttg   6720

actaaacctt ttcctaagct atctctcatg gttcctatgt ttttttatca taattaaaag   6780

caaaaccatc tggatcacct aacagtcaga ggtcagtatc tcagcgtgtg aattatagag   6840

gaaatacaga gagaacctct tccactttta cttttcgtcc aaataaaatg catggtgtac   6900

cagaagttga agatcgggtt gaggattggg gctagctcga tgacactaag gccccaacat   6960

cgcgggacct gctgtggcgc ggattcttag gaacgctgtt ctagccggcc ccctctccag   7020

gggtcgccgt ggccggcatt atttcctagt tcttcttgta accctgaggt gccagcgcgg   7080

ggagtgagga ggggtcaggg ggctaaggat gcaacctctg acgttctgcg ccttcctagg   7140

agagtcttac atgtgttgag atttcacaag caatgcgagt tgtaaaatac cagctctaca   7200

agaagctagg ctctgtgacg gcatagtttt cagtagcttt atcacaatat tcacaatgga   7260

gaattatatg acatggtagc agaaataggc ccttttatgt gttgcttcta ttttacctca   7320

aattgtagat atagggtaat caataaaatc catccatgcc tttcacacac taagt        7375


<210>  4629
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  4629

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala 



<210>  4630
<211>  7820
<212>  DNA
<213>  Homo sapiens

<400>  4630
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagctca agctcttgga ctcaccgagg   1980

cagtaaaagt accatatcct gtgtttgaat caaacccgga gttcttgtat gtggaaggct   2040

tgccagaggg gattcccttc cgaagcccta cctggtttgg aattccacga cttgaaagga   2100

tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa acctgaacta gttatttcct   2160

acttgcctcc tgggatggct agtaaaataa acactaaagc tttgcagtcc cccaaaagac   2220

cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta   2280

ataacaacaa tcctcaaacc tcagctgttc gaaccccgac ccagactaac ggttctaacg   2340

ttcccttcaa gccacgaggg agagagtttt cctttgaggc ctggaatgcc aaaatcacgg   2400

acctaaaaca gaaagttgaa aatctcttca atgagaaatg tggggaagct cttggcctta   2460

aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg   2520

aaggcttacc tgagggtgtg ccattccgaa gaccatcgac ttttggcatt ccgaggctgg   2580

agaagatact cagaaacaaa gccaaaatta agttcatcat taaaaagccc gaaatgtttg   2640

agacggcgat taaggagagc acctcctcta agagccctcc cagaaaaata aattcatcac   2700

ccaatgttaa tactactgca tcaggtgttg aagaccttaa catcattcag gtgacaattc   2760

cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta agagaacaag   2820

tgaatgacct ctttagtcgg aaatttggtg aagctattgg tatgggtttt cctgtgaaag   2880

ttccctacag gaaaatcaca attaaccctg gctgtgtggt ggttgatggc atgcccccgg   2940

gggtgtcctt caaagccccc agctacctgg aaatcagctc catgagaagg atcttagact   3000

ctgccgagtt tatcaaattc acggtcatta ggtaagtgag agtttcctgc ttagtcacag   3060

gagcgaatct ggagctcatg aggctgactc ttctaaaatg cagccacagg tagtcatcga   3120

atccggcttc ctatgctgtg caatcaacaa atcaaaataa cttgtgtcat cattagaatg   3180

tcagatgtgc ttctacgaac taagctgact cttttaattc tttggcaaag ggttggcaaa   3240

ctaggactgt ttgccaaatt caggctgcct cctattttta gagtcttcct gaaacacagc   3300

tacacccgta ttatccatgg ctgctttcct gtcacagtga gtaagtagct gggactgaga   3360

aggcatggcc tccaaagtct aaaatattta ctctctagca ctttgtagaa aaaccttagc   3420

taggcacagt ggctaacgcc tgtaatccca gcattttggg aggccaaggc aggcagatca   3480

cctgaggtca ggagttccag accagcctgg ccaacatggt gaaatcccat ctctacaaaa   3540

ataaaacagt tagctgggca tgatggcggg tgcctgtaat cccagctact cgggaggctg   3600

aggcaggata gtcgcttgaa cccaggaggt ggaggttgca atgagccaag atcatgccac   3660

tgcactccag cctggacgac agagtgagac tccatcacaa gaaaaaaaga actttgtcaa   3720

cctctgtctt agggcgcctt gtcacaggct tcgggtcaga cggattcaac cttgcatcag   3780

ccatttgtta gccaggtcac tctgttcttt gtctgtaaat gagattgatc gttgttccca   3840

ctgagagtgt cagctccttc ccgtagagca ggcatgatga ttgtactcac ctctgacacc   3900

attgtgagtg ccacattcct tcccacgtcc ttgtcactgt aagagatgcc cacctgagca   3960

ccaaccccag gttatcttcc cctttgtctt ccagcccccc agaaacagct acgactcaac   4020

ctacccaatc atttcatcat cagattgcca ctgtctctag ttcaggtctc ttgggactgg   4080

cactcagaaa tctcataata aatcctcttg aggcttctca tacactcgtc ttcttccaat   4140

cttctttccc tcaaaatctc atattttggt tccacttcac ccaccgtcat tctccatatc   4200

actcccagga gttaggcaaa aagccccttc cgttcttccg tatgttaaac ttagaatcac   4260

tctgttccct gctctgcgtt tctatttttt gtttttcctc catttactag tagcttaaca   4320

ctttctaaca gtgttcttat tattgatacg tatctatctc ttccataagc ttataaggtc   4380

acggataata cttctcattg tagtacgtaa atgacgtggg ctagatatga gttgaataaa   4440

cagttatacc tgtaaattct tacagagtga aaataaattg ttatacttta caatttgttt   4500

ctctctttag accatttcca ggacttgtga ttaataaccg tgagtatttt gtgaagtgtt   4560

ttgtttttgt tttttcctgg ggtctgacgt gtgtgcgtgt gagtgtgtat acatgcttaa   4620

cgtatatcac gttacttcac ctatgtcagt aaccaggcca aatacttgtt ttagccctca   4680

gtaaaaacac caggcacttc ctagttgtaa aattattcaa gcttcttaac ttcctatcct   4740

cgatgcactt aatcataaaa tggtaataat agcaccgatt ttgggggagt cgttccagta   4800

gatggaaagc atctggaaca ggtgtcagca agctcctgcc gacgtgtatg cataaagttt   4860

tattgaaacc accatcgtgt ccatttgttt atggcagaac tgagagatgg cagcagcaag   4920

tgtgtgcctg caaaacctaa aatatttact aattggctct gcaagaaaag agtttgcatc   4980

cccctaacct agaacagtgt ctagcctcta gtatgtgttt agcctacagt atgtgctcag   5040

cgaatacaat ctatatttat tactgctttt atgactgtta taattactgt gcttggattt   5100

cgttacaaag taagtcacaa tgtgcctgct tctgttagta tttcagcaca gtgcctggca   5160

cacatggggc tctcaaatat tgctgagcga gtgaacaaat gtcctttcaa ttccttaacg   5220

ttgatgtcat tttcaatagt attttgagcc aaacttaatt ttgcgagtgt gttttgtttt   5280

cttaacttta ttattaaaaa tgtataaaag tgaggccagg cgtggtggct cacgcctgta   5340

atcccagcag tttgggaggc tgaggcaggc ggatcagttg aggttgggag ttggagacca   5400

gcccgtccaa catggtgaaa gcctgtctct actaaaaata caaaaatcag ctgggtgtgg   5460

tggcgcgtgc ctgtaatccc agctactcag gaggctgagg caggagagtt gcttgaatcc   5520

tagaggtgga ggttgcagtg agctgagatc gtgccattgc actccagcct gggcaacaag   5580

agcaaaactc tgtcccaata aataaataaa taaaatgttc tcttttgttc ctgttcttgt   5640

gcggtagtgt ggtatagagt tttatggtaa ttactgtgaa ttagtgattc tgagggacat   5700

atcagaactc tgaggtttgt ttccttctca tcttgaggga aacagcaaat gtatgttaaa   5760

atgcttttcc aagggaacaa cacatcctta cattatttaa accaatctgc ttcattttca   5820

gagctggttg atcagagtga gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc   5880

cagttggaag ttccagccac agaagaaata aaagagactg atggaagctc tcagatcaag   5940

caagaaccag accccacgtg gtagacctct tccctcctag ggtaaatcag cttctgtgtc   6000

agggatgctg tgtggtgtcc atctgaaccc cctgcatacg cgtagctaat gtgatctccc   6060

cactttcaca taagatggtg gccctgcctt cagggaatgt gggagccagg tgggagcctt   6120

cccggatatt taagctagaa gattctacag ggagattctc cttggatcaa tatatgtctc   6180

tcagtcaaag atgtaaaagc acttttgcct taaaaagaat gttctgtttc taaatagagt   6240

caacgttgtc ctcctcattg gaattcacta tgagtcagaa tcattagact gacttttttt   6300

tttccatagt aatagtattt tgcagagtct cacagagctg cagatctttt gttcatcttg   6360

cagagttaac aagtctgatc ctgttagtcc agatttctta aatttggcca agttataata   6420

ggagcagtag cttgagaccc gaagtcagga aactttgaca atggattttt ttttttaatc   6480

cagagacttg tactggaatt tgccttaccc tgtcagctca tggacttaag gtttcatccc   6540

gctttatgag tgcttctgaa tccaagtcat tgttacctga atttgcaaat taagttgtga   6600

tattcgtgac tgttaaattc ctgtaattag attaacctct ttgcttgctt gtttgttttc   6660

tctcctattt tagcttaaag tatcagtggt tgagaagagc ttttcggacc tgttactacc   6720

ccaagctgtg taatatactt gtataacaga aataccttct atacaaacct ttttttctac   6780

ttttagatag aaatgtctac tttttcagca gttctgtgaa ttaaagagca gagtgactgt   6840

gggtctggaa tggctggtgt acttgggaat gtactatcag gattttacag caatgctggg   6900

aaatgacagg gaaaatgaca ggaatgaatc tcaccagatt ttttatgtac tcagcagagc   6960

cttgagttac ggtgtttatt ttccaatcaa gtgaagatat ctcctacttc tcctactgga   7020

acatctcagc ttctgcagtg aagaaaaatt cctgtgatag ttcagttctt tagtttttct   7080

atttgaaaaa aaaaaatcat ttaaatgatc ctttgttcac ggctctcctt aatgactgag   7140

tgaacagttc ctatctgtat atttgactaa accttttcct aagctatctc tcatggttcc   7200

tatgtttttt tatcataatt aaaagcaaaa ccatctggat cacctaacag tcagaggtca   7260

gtatctcagc gtgtgaatta tagaggaaat acagagagaa cctcttccac ttttactttt   7320

cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc gggttgagga ttggggctag   7380

ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg   7440

ctgttctagc cggccccctc tccaggggtc gccgtggccg gcattatttc ctagttcttc   7500

ttgtaaccct gaggtgccag cgcggggagt gaggaggggt cagggggcta aggatgcaac   7560

ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg ttgagatttc acaagcaatg   7620

cgagttgtaa aataccagct ctacaagaag ctaggctctg tgacggcata gttttcagta   7680

gctttatcac aatattcaca atggagaatt atatgacatg gtagcagaaa taggcccttt   7740

tatgtgttgc ttctatttta cctcaaattg tagatatagg gtaatcaata aaatccatcc   7800

atgcctttca cacactaagt                                               7820


<210>  4631
<211>  877
<212>  PRT
<213>  Homo sapiens

<400>  4631

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
        515                 520                 525


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
    530                 535                 540


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
545                 550                 555                 560


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
                565                 570                 575


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
            580                 585                 590


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
        595                 600                 605


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
    610                 615                 620


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
625                 630                 635                 640


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
                645                 650                 655


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
            660                 665                 670


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
        675                 680                 685


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
    690                 695                 700


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
705                 710                 715                 720


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
                725                 730                 735


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
            740                 745                 750


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
        755                 760                 765


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
    770                 775                 780


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
785                 790                 795                 800


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
                805                 810                 815


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
            820                 825                 830


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
        835                 840                 845


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
    850                 855                 860


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
865                 870                 875


<210>  4632
<211>  4372
<212>  DNA
<213>  Homo sapiens

<400>  4632
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gctcaagctc ttggactcac   1980

cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct tgtatgtgga   2040

aggcttgcca gaggggattc ccttccgaag ccctacctgg tttggaattc cacgacttga   2100

aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg aactagttat   2160

ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc agtcccccaa   2220

aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg   2280

ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga ctaacggttc   2340

taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga atgccaaaat   2400

cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg   2460

ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg aagactttta   2520

tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg gcattccgag   2580

gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa agcccgaaat   2640

gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa aaataaattc   2700

atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca ttcaggtgac   2760

aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac agctaagaga   2820

acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg gttttcctgt   2880

gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg atggcatgcc   2940

cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga gaaggatctt   3000

agactctgcc gagtttatca aattcacggt cattagacca tttccaggac ttgtgattaa   3060

taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat cagctgaacc   3120

aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa gctctcagat   3180

caagcaagaa ccagacccca cgtggtagac ctcttccctc ctaggcttaa agtatcagtg   3240

gttgagaaga gcttttcgga cctgttacta ccccaagctg tgtaatatac ttgtataaca   3300

gaaatacctt ctatacaaac ctttttttct acttttagat agaaatgtct actttttcag   3360

cagttctgtg aattaaagag cagagtgact gtgggtctgg aatggctggt gtacttggga   3420

atgtactatc aggattttac agcaatgctg ggaaatgaca gggaaaatga caggaatgaa   3480

tctcaccaga ttttttatgt actcagcaga gccttgagtt acggtgttta ttttccaatc   3540

aagtgaagat atctcctact tctcctactg gaacatctca gcttctgcag tgaagaaaaa   3600

ttcctgtgat agttcagttc tttagttttt ctatttgaaa aaaaaaaatc atttaaatga   3660

tcctttgttc acggctctcc ttaatgactg agtgaacagt tcctatctgt atatttgact   3720

aaaccttttc ctaagctatc tctcatggtt cctatgtttt tttatcataa ttaaaagcaa   3780

aaccatctgg atcacctaac agtcagaggt cagtatctca gcgtgtgaat tatagaggaa   3840

atacagagag aacctcttcc acttttactt ttcgtccaaa taaaatgcat ggtgtaccag   3900

aagttgaaga tcgggttgag gattggggct agctcgatga cactaaggcc ccaacatcgc   3960

gggacctgct gtggcgcgga ttcttaggaa cgctgttcta gccggccccc tctccagggg   4020

tcgccgtggc cggcattatt tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga   4080

gtgaggaggg gtcagggggc taaggatgca acctctgacg ttctgcgcct tcctaggaga   4140

gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt aaaataccag ctctacaaga   4200

agctaggctc tgtgacggca tagttttcag tagctttatc acaatattca caatggagaa   4260

ttatatgaca tggtagcaga aataggccct tttatgtgtt gcttctattt tacctcaaat   4320

tgtagatata gggtaatcaa taaaatccat ccatgccttt cacacactaa gt           4372


<210>  4633
<211>  928
<212>  PRT
<213>  Homo sapiens

<400>  4633

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro 
        515                 520                 525


Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu 
    530                 535                 540


Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu 
545                 550                 555                 560


Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro 
                565                 570                 575


Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn 
            580                 585                 590


Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn 
        595                 600                 605


Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn 
    610                 615                 620


Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser 
625                 630                 635                 640


Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp 
                645                 650                 655


Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn 
            660                 665                 670


Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro 
        675                 680                 685


Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu 
    690                 695                 700


Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg 
705                 710                 715                 720


Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys 
                725                 730                 735


Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys 
            740                 745                 750


Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala 
        755                 760                 765


Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp 
    770                 775                 780


Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu 
785                 790                 795                 800


Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met 
                805                 810                 815


Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly 
            820                 825                 830


Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro 
        835                 840                 845


Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu 
    850                 855                 860


Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn 
865                 870                 875                 880


Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu 
                885                 890                 895


Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys 
            900                 905                 910


Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
        915                 920                 925


<210>  4634
<211>  7116
<212>  DNA
<213>  Homo sapiens

<400>  4634
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1980

catatcctgt gtttgaatca aacccggagt tcttgtatgt ggaaggcttg ccagagggga   2040

ttcccttccg aagccctacc tggtttggaa ttccacgact tgaaaggatc gtccgcggga   2100

gtaataaaat caagttcgtt gttaaaaaac ctgaactagt tatttcctac ttgcctcctg   2160

ggatggctag taaaataaac actaaagctt tgcagtcccc caaaagacca cgaagtcctg   2220

ggagtaattc aaaggttcct gaaattgagg tcaccgtgga aggccctaat aacaacaatc   2280

ctcaaacctc agctgttcga accccgaccc agactaacgg ttctaacgtt cccttcaagc   2340

cacgagggag agagttttcc tttgaggcct ggaatgccaa aatcacggac ctaaaacaga   2400

aagttgaaaa tctcttcaat gagaaatgtg gggaagctct tggccttaaa caagctgtga   2460

aggtgccgtt cgcgttattt gagtctttcc cggaagactt ttatgtggaa ggcttacctg   2520

agggtgtgcc attccgaaga ccatcgactt ttggcattcc gaggctggag aagatactca   2580

gaaacaaagc caaaattaag ttcatcatta aaaagcccga aatgtttgag acggcgatta   2640

aggagagcac ctcctctaag agccctccca gaaaaataaa ttcatcaccc aatgttaata   2700

ctactgcatc aggtgttgaa gaccttaaca tcattcaggt gacaattcca gatgatgata   2760

atgaaagact ctcgaaagtt gaaaaagcta gacagctaag agaacaagtg aatgacctct   2820

ttagtcggaa atttggtgaa gctattggta tgggttttcc tgtgaaagtt ccctacagga   2880

aaatcacaat taaccctggc tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca   2940

aagcccccag ctacctggaa atcagctcca tgagaaggat cttagactct gccgagttta   3000

tcaaattcac ggtcattagg taagtgagag tttcctgctt agtcacagga gcgaatctgg   3060

agctcatgag gctgactctt ctaaaatgca gccacaggta gtcatcgaat ccggcttcct   3120

atgctgtgca atcaacaaat caaaataact tgtgtcatca ttagaatgtc agatgtgctt   3180

ctacgaacta agctgactct tttaattctt tggcaaaggg ttggcaaact aggactgttt   3240

gccaaattca ggctgcctcc tatttttaga gtcttcctga aacacagcta cacccgtatt   3300

atccatggct gctttcctgt cacagtgagt aagtagctgg gactgagaag gcatggcctc   3360

caaagtctaa aatatttact ctctagcact ttgtagaaaa accttagcta ggcacagtgg   3420

ctaacgcctg taatcccagc attttgggag gccaaggcag gcagatcacc tgaggtcagg   3480

agttccagac cagcctggcc aacatggtga aatcccatct ctacaaaaat aaaacagtta   3540

gctgggcatg atggcgggtg cctgtaatcc cagctactcg ggaggctgag gcaggatagt   3600

cgcttgaacc caggaggtgg aggttgcaat gagccaagat catgccactg cactccagcc   3660

tggacgacag agtgagactc catcacaaga aaaaaagaac tttgtcaacc tctgtcttag   3720

ggcgccttgt cacaggcttc gggtcagacg gattcaacct tgcatcagcc atttgttagc   3780

caggtcactc tgttctttgt ctgtaaatga gattgatcgt tgttcccact gagagtgtca   3840

gctccttccc gtagagcagg catgatgatt gtactcacct ctgacaccat tgtgagtgcc   3900

acattccttc ccacgtcctt gtcactgtaa gagatgccca cctgagcacc aaccccaggt   3960

tatcttcccc tttgtcttcc agccccccag aaacagctac gactcaacct acccaatcat   4020

ttcatcatca gattgccact gtctctagtt caggtctctt gggactggca ctcagaaatc   4080

tcataataaa tcctcttgag gcttctcata cactcgtctt cttccaatct tctttccctc   4140

aaaatctcat attttggttc cacttcaccc accgtcattc tccatatcac tcccaggagt   4200

taggcaaaaa gccccttccg ttcttccgta tgttaaactt agaatcactc tgttccctgc   4260

tctgcgtttc tattttttgt ttttcctcca tttactagta gcttaacact ttctaacagt   4320

gttcttatta ttgatacgta tctatctctt ccataagctt ataaggtcac ggataatact   4380

tctcattgta gtacgtaaat gacgtgggct agatatgagt tgaataaaca gttatacctg   4440

taaattctta cagagtgaaa ataaattgtt atactttaca atttgtttct ctctttagac   4500

catttccagg acttgtgatt aataaccgtg agtattttgt gaagtgtttt gtttttgttt   4560

tttcctgggg tctgacgtgt gtgcgtgtga gtgtgtatac atgcttaacg tatatcacgt   4620

tacttcacct atgtcagtaa ccaggccaaa tacttgtttt agccctcagt aaaaacacca   4680

ggcacttcct agttgtaaaa ttattcaagc ttcttaactt cctatcctcg atgcacttaa   4740

tcataaaatg gtaataatag caccgatttt gggggagtcg ttccagtaga tggaaagcat   4800

ctggaacagg tgtcagcaag ctcctgccga cgtgtatgca taaagtttta ttgaaaccac   4860

catcgtgtcc atttgtttat ggcagaactg agagatggca gcagcaagtg tgtgcctgca   4920

aaacctaaaa tatttactaa ttggctctgc aagaaaagag tttgcatccc cctaacctag   4980

aacagtgtct agcctctagt atgtgtttag cctacagtat gtgctcagcg aatacaatct   5040

atatttatta ctgcttttat gactgttata attactgtgc ttggatttcg ttacaaagta   5100

agtcacaatg tgcctgcttc tgttagtatt tcagcacagt gcctggcaca catggggctc   5160

tcaaatattg ctgagcgagt gaacaaatgt cctttcaatt ccttaacgtt gatgtcattt   5220

tcaatagtat tttgagccaa acttaatttt gcgagtgtgt tttgttttct taactttatt   5280

attaaaaatg tataaaagtg aggccaggcg tggtggctca cgcctgtaat cccagcagtt   5340

tgggaggctg aggcaggcgg atcagttgag gttgggagtt ggagaccagc ccgtccaaca   5400

tggtgaaagc ctgtctctac taaaaataca aaaatcagct gggtgtggtg gcgcgtgcct   5460

gtaatcccag ctactcagga ggctgaggca ggagagttgc ttgaatccta gaggtggagg   5520

ttgcagtgag ctgagatcgt gccattgcac tccagcctgg gcaacaagag caaaactctg   5580

tcccaataaa taaataaata aaatgttctc ttttgttcct gttcttgtgc ggtagtgtgg   5640

tatagagttt tatggtaatt actgtgaatt agtgattctg agggacatat cagaactctg   5700

aggtttgttt ccttctcatc ttgagggaaa cagcaaatgt atgttaaaat gcttttccaa   5760

gggaacaaca catccttaca ttatttaaac caatctgctt cattttcaga gctggttgat   5820

cagagtgagt cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt   5880

ccagccacag aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac   5940

cccacgtggt agacctcttc cctcctaggc ttaaagtatc agtggttgag aagagctttt   6000

cggacctgtt actaccccaa gctgtgtaat atacttgtat aacagaaata ccttctatac   6060

aaaccttttt ttctactttt agatagaaat gtctactttt tcagcagttc tgtgaattaa   6120

agagcagagt gactgtgggt ctggaatggc tggtgtactt gggaatgtac tatcaggatt   6180

ttacagcaat gctgggaaat gacagggaaa atgacaggaa tgaatctcac cagatttttt   6240

atgtactcag cagagccttg agttacggtg tttattttcc aatcaagtga agatatctcc   6300

tacttctcct actggaacat ctcagcttct gcagtgaaga aaaattcctg tgatagttca   6360

gttctttagt ttttctattt gaaaaaaaaa aatcatttaa atgatccttt gttcacggct   6420

ctccttaatg actgagtgaa cagttcctat ctgtatattt gactaaacct tttcctaagc   6480

tatctctcat ggttcctatg tttttttatc ataattaaaa gcaaaaccat ctggatcacc   6540

taacagtcag aggtcagtat ctcagcgtgt gaattataga ggaaatacag agagaacctc   6600

ttccactttt acttttcgtc caaataaaat gcatggtgta ccagaagttg aagatcgggt   6660

tgaggattgg ggctagctcg atgacactaa ggccccaaca tcgcgggacc tgctgtggcg   6720

cggattctta ggaacgctgt tctagccggc cccctctcca ggggtcgccg tggccggcat   6780

tatttcctag ttcttcttgt aaccctgagg tgccagcgcg gggagtgagg aggggtcagg   6840

gggctaagga tgcaacctct gacgttctgc gccttcctag gagagtctta catgtgttga   6900

gatttcacaa gcaatgcgag ttgtaaaata ccagctctac aagaagctag gctctgtgac   6960

ggcatagttt tcagtagctt tatcacaata ttcacaatgg agaattatat gacatggtag   7020

cagaaatagg cccttttatg tgttgcttct attttacctc aaattgtaga tatagggtaa   7080

tcaataaaat ccatccatgc ctttcacaca ctaagt                             7116


<210>  4635
<211>  812
<212>  PRT
<213>  Homo sapiens

<400>  4635

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
            420                 425                 430


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
        435                 440                 445


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
    450                 455                 460


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu 
465                 470                 475                 480


Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile 
                485                 490                 495


Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val 
            500                 505                 510


Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala 
        515                 520                 525


Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser 
    530                 535                 540


Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly 
545                 550                 555                 560


Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln 
                565                 570                 575


Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser 
            580                 585                 590


Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu 
        595                 600                 605


Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala 
    610                 615                 620


Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr 
625                 630                 635                 640


Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe 
                645                 650                 655


Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys 
            660                 665                 670


Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser 
        675                 680                 685


Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val 
    690                 695                 700


Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr 
705                 710                 715                 720


Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg 
                725                 730                 735


Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu 
            740                 745                 750


Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr 
        755                 760                 765


Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser 
    770                 775                 780


Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu 
785                 790                 795                 800


Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
                805                 810


<210>  4636
<211>  7832
<212>  DNA
<213>  Homo sapiens

<400>  4636
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1920

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   1980

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttgt   2040

atgtggaagg cttgccagag gggattccct tccgaagccc tacctggttt ggaattccac   2100

gacttgaaag gatcgtccgc gggagtaata aaatcaagtt cgttgttaaa aaacctgaac   2160

tagttatttc ctacttgcct cctgggatgg ctagtaaaat aaacactaaa gctttgcagt   2220

cccccaaaag accacgaagt cctgggagta attcaaaggt tcctgaaatt gaggtcaccg   2280

tggaaggccc taataacaac aatcctcaaa cctcagctgt tcgaaccccg acccagacta   2340

acggttctaa cgttcccttc aagccacgag ggagagagtt ttcctttgag gcctggaatg   2400

ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt caatgagaaa tgtggggaag   2460

ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt atttgagtct ttcccggaag   2520

acttttatgt ggaaggctta cctgagggtg tgccattccg aagaccatcg acttttggca   2580

ttccgaggct ggagaagata ctcagaaaca aagccaaaat taagttcatc attaaaaagc   2640

ccgaaatgtt tgagacggcg attaaggaga gcacctcctc taagagccct cccagaaaaa   2700

taaattcatc acccaatgtt aatactactg catcaggtgt tgaagacctt aacatcattc   2760

aggtgacaat tccagatgat gataatgaaa gactctcgaa agttgaaaaa gctagacagc   2820

taagagaaca agtgaatgac ctctttagtc ggaaatttgg tgaagctatt ggtatgggtt   2880

ttcctgtgaa agttccctac aggaaaatca caattaaccc tggctgtgtg gtggttgatg   2940

gcatgccccc gggggtgtcc ttcaaagccc ccagctacct ggaaatcagc tccatgagaa   3000

ggatcttaga ctctgccgag tttatcaaat tcacggtcat taggtaagtg agagtttcct   3060

gcttagtcac aggagcgaat ctggagctca tgaggctgac tcttctaaaa tgcagccaca   3120

ggtagtcatc gaatccggct tcctatgctg tgcaatcaac aaatcaaaat aacttgtgtc   3180

atcattagaa tgtcagatgt gcttctacga actaagctga ctcttttaat tctttggcaa   3240

agggttggca aactaggact gtttgccaaa ttcaggctgc ctcctatttt tagagtcttc   3300

ctgaaacaca gctacacccg tattatccat ggctgctttc ctgtcacagt gagtaagtag   3360

ctgggactga gaaggcatgg cctccaaagt ctaaaatatt tactctctag cactttgtag   3420

aaaaacctta gctaggcaca gtggctaacg cctgtaatcc cagcattttg ggaggccaag   3480

gcaggcagat cacctgaggt caggagttcc agaccagcct ggccaacatg gtgaaatccc   3540

atctctacaa aaataaaaca gttagctggg catgatggcg ggtgcctgta atcccagcta   3600

ctcgggaggc tgaggcagga tagtcgcttg aacccaggag gtggaggttg caatgagcca   3660

agatcatgcc actgcactcc agcctggacg acagagtgag actccatcac aagaaaaaaa   3720

gaactttgtc aacctctgtc ttagggcgcc ttgtcacagg cttcgggtca gacggattca   3780

accttgcatc agccatttgt tagccaggtc actctgttct ttgtctgtaa atgagattga   3840

tcgttgttcc cactgagagt gtcagctcct tcccgtagag caggcatgat gattgtactc   3900

acctctgaca ccattgtgag tgccacattc cttcccacgt ccttgtcact gtaagagatg   3960

cccacctgag caccaacccc aggttatctt cccctttgtc ttccagcccc ccagaaacag   4020

ctacgactca acctacccaa tcatttcatc atcagattgc cactgtctct agttcaggtc   4080

tcttgggact ggcactcaga aatctcataa taaatcctct tgaggcttct catacactcg   4140

tcttcttcca atcttctttc cctcaaaatc tcatattttg gttccacttc acccaccgtc   4200

attctccata tcactcccag gagttaggca aaaagcccct tccgttcttc cgtatgttaa   4260

acttagaatc actctgttcc ctgctctgcg tttctatttt ttgtttttcc tccatttact   4320

agtagcttaa cactttctaa cagtgttctt attattgata cgtatctatc tcttccataa   4380

gcttataagg tcacggataa tacttctcat tgtagtacgt aaatgacgtg ggctagatat   4440

gagttgaata aacagttata cctgtaaatt cttacagagt gaaaataaat tgttatactt   4500

tacaatttgt ttctctcttt agaccatttc caggacttgt gattaataac cgtgagtatt   4560

ttgtgaagtg ttttgttttt gttttttcct ggggtctgac gtgtgtgcgt gtgagtgtgt   4620

atacatgctt aacgtatatc acgttacttc acctatgtca gtaaccaggc caaatacttg   4680

ttttagccct cagtaaaaac accaggcact tcctagttgt aaaattattc aagcttctta   4740

acttcctatc ctcgatgcac ttaatcataa aatggtaata atagcaccga ttttggggga   4800

gtcgttccag tagatggaaa gcatctggaa caggtgtcag caagctcctg ccgacgtgta   4860

tgcataaagt tttattgaaa ccaccatcgt gtccatttgt ttatggcaga actgagagat   4920

ggcagcagca agtgtgtgcc tgcaaaacct aaaatattta ctaattggct ctgcaagaaa   4980

agagtttgca tccccctaac ctagaacagt gtctagcctc tagtatgtgt ttagcctaca   5040

gtatgtgctc agcgaataca atctatattt attactgctt ttatgactgt tataattact   5100

gtgcttggat ttcgttacaa agtaagtcac aatgtgcctg cttctgttag tatttcagca   5160

cagtgcctgg cacacatggg gctctcaaat attgctgagc gagtgaacaa atgtcctttc   5220

aattccttaa cgttgatgtc attttcaata gtattttgag ccaaacttaa ttttgcgagt   5280

gtgttttgtt ttcttaactt tattattaaa aatgtataaa agtgaggcca ggcgtggtgg   5340

ctcacgcctg taatcccagc agtttgggag gctgaggcag gcggatcagt tgaggttggg   5400

agttggagac cagcccgtcc aacatggtga aagcctgtct ctactaaaaa tacaaaaatc   5460

agctgggtgt ggtggcgcgt gcctgtaatc ccagctactc aggaggctga ggcaggagag   5520

ttgcttgaat cctagaggtg gaggttgcag tgagctgaga tcgtgccatt gcactccagc   5580

ctgggcaaca agagcaaaac tctgtcccaa taaataaata aataaaatgt tctcttttgt   5640

tcctgttctt gtgcggtagt gtggtataga gttttatggt aattactgtg aattagtgat   5700

tctgagggac atatcagaac tctgaggttt gtttccttct catcttgagg gaaacagcaa   5760

atgtatgtta aaatgctttt ccaagggaac aacacatcct tacattattt aaaccaatct   5820

gcttcatttt cagagctggt tgatcagagt gagtcagaag gccccgtgat acaagaatca   5880

gctgaaccaa gccagttgga agttccagcc acagaagaaa taaaagagac tgatggaagc   5940

tctcagatca agcaagaacc agaccccacg tggtagacct cttccctcct agggtaaatc   6000

agcttctgtg tcagggatgc tgtgtggtgt ccatctgaac cccctgcata cgcgtagcta   6060

atgtgatctc cccactttca cataagatgg tggccctgcc ttcagggaat gtgggagcca   6120

ggtgggagcc ttcccggata tttaagctag aagattctac agggagattc tccttggatc   6180

aatatatgtc tctcagtcaa agatgtaaaa gcacttttgc cttaaaaaga atgttctgtt   6240

tctaaataga gtcaacgttg tcctcctcat tggaattcac tatgagtcag aatcattaga   6300

ctgacttttt tttttccata gtaatagtat tttgcagagt ctcacagagc tgcagatctt   6360

ttgttcatct tgcagagtta acaagtctga tcctgttagt ccagatttct taaatttggc   6420

caagttataa taggagcagt agcttgagac ccgaagtcag gaaactttga caatggattt   6480

ttttttttaa tccagagact tgtactggaa tttgccttac cctgtcagct catggactta   6540

aggtttcatc ccgctttatg agtgcttctg aatccaagtc attgttacct gaatttgcaa   6600

attaagttgt gatattcgtg actgttaaat tcctgtaatt agattaacct ctttgcttgc   6660

ttgtttgttt tctctcctat tttagcttaa agtatcagtg gttgagaaga gcttttcgga   6720

cctgttacta ccccaagctg tgtaatatac ttgtataaca gaaatacctt ctatacaaac   6780

ctttttttct acttttagat agaaatgtct actttttcag cagttctgtg aattaaagag   6840

cagagtgact gtgggtctgg aatggctggt gtacttggga atgtactatc aggattttac   6900

agcaatgctg ggaaatgaca gggaaaatga caggaatgaa tctcaccaga ttttttatgt   6960

actcagcaga gccttgagtt acggtgttta ttttccaatc aagtgaagat atctcctact   7020

tctcctactg gaacatctca gcttctgcag tgaagaaaaa ttcctgtgat agttcagttc   7080

tttagttttt ctatttgaaa aaaaaaaatc atttaaatga tcctttgttc acggctctcc   7140

ttaatgactg agtgaacagt tcctatctgt atatttgact aaaccttttc ctaagctatc   7200

tctcatggtt cctatgtttt tttatcataa ttaaaagcaa aaccatctgg atcacctaac   7260

agtcagaggt cagtatctca gcgtgtgaat tatagaggaa atacagagag aacctcttcc   7320

acttttactt ttcgtccaaa taaaatgcat ggtgtaccag aagttgaaga tcgggttgag   7380

gattggggct agctcgatga cactaaggcc ccaacatcgc gggacctgct gtggcgcgga   7440

ttcttaggaa cgctgttcta gccggccccc tctccagggg tcgccgtggc cggcattatt   7500

tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc   7560

taaggatgca acctctgacg ttctgcgcct tcctaggaga gtcttacatg tgttgagatt   7620

tcacaagcaa tgcgagttgt aaaataccag ctctacaaga agctaggctc tgtgacggca   7680

tagttttcag tagctttatc acaatattca caatggagaa ttatatgaca tggtagcaga   7740

aataggccct tttatgtgtt gcttctattt tacctcaaat tgtagatata gggtaatcaa   7800

taaaatccat ccatgccttt cacacactaa gt                                 7832


<210>  4637
<211>  881
<212>  PRT
<213>  Homo sapiens

<400>  4637

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
            500                 505                 510


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
        515                 520                 525


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
    530                 535                 540


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
545                 550                 555                 560


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
                565                 570                 575


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
            580                 585                 590


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
        595                 600                 605


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
    610                 615                 620


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
625                 630                 635                 640


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
                645                 650                 655


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
            660                 665                 670


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
        675                 680                 685


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
    690                 695                 700


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
705                 710                 715                 720


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
                725                 730                 735


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
            740                 745                 750


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
        755                 760                 765


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
    770                 775                 780


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
785                 790                 795                 800


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
                805                 810                 815


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
            820                 825                 830


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
        835                 840                 845


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
    850                 855                 860


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
865                 870                 875                 880


Arg 



<210>  4638
<211>  7213
<212>  DNA
<213>  Homo sapiens

<400>  4638
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1860

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1920

tgaaatttgc ttagatttgt tgacagcggt ttcctggagt gctgtcttga gaacgattct   1980

gaggaggctc agcaagaaag agtgtttcag ttgattgggt gtgtctgtca tggagaagga   2040

actcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac   2100

ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg   2160

tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2220

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2280

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2340

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2400

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2460

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2520

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2580

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2640

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2700

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2760

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2820

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2880

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2940

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   3000

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3060

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattaggtaa   3120

gtgagagttt cctgcttagt cacaggagcg aatctggagc tcatgaggct gactcttcta   3180

aaatgcagcc acaggtagtc atcgaatccg gcttcctatg ctgtgcaatc aacaaatcaa   3240

aataacttgt gtcatcatta gaatgtcaga tgtgcttcta cgaactaagc tgactctttt   3300

aattctttgg caaagggttg gcaaactagg actgtttgcc aaattcaggc tgcctcctat   3360

ttttagagtc ttcctgaaac acagctacac ccgtattatc catggctgct ttcctgtcac   3420

agtgagtaag tagctgggac tgagaaggca tggcctccaa agtctaaaat atttactctc   3480

tagcactttg tagaaaaacc ttagctaggc acagtggcta acgcctgtaa tcccagcatt   3540

ttgggaggcc aaggcaggca gatcacctga ggtcaggagt tccagaccag cctggccaac   3600

atggtgaaat cccatctcta caaaaataaa acagttagct gggcatgatg gcgggtgcct   3660

gtaatcccag ctactcggga ggctgaggca ggatagtcgc ttgaacccag gaggtggagg   3720

ttgcaatgag ccaagatcat gccactgcac tccagcctgg acgacagagt gagactccat   3780

cacaagaaaa aaagaacttt gtcaacctct gtcttagggc gccttgtcac aggcttcggg   3840

tcagacggat tcaaccttgc atcagccatt tgttagccag gtcactctgt tctttgtctg   3900

taaatgagat tgatcgttgt tcccactgag agtgtcagct ccttcccgta gagcaggcat   3960

gatgattgta ctcacctctg acaccattgt gagtgccaca ttccttccca cgtccttgtc   4020

actgtaagag atgcccacct gagcaccaac cccaggttat cttccccttt gtcttccagc   4080

cccccagaaa cagctacgac tcaacctacc caatcatttc atcatcagat tgccactgtc   4140

tctagttcag gtctcttggg actggcactc agaaatctca taataaatcc tcttgaggct   4200

tctcatacac tcgtcttctt ccaatcttct ttccctcaaa atctcatatt ttggttccac   4260

ttcacccacc gtcattctcc atatcactcc caggagttag gcaaaaagcc ccttccgttc   4320

ttccgtatgt taaacttaga atcactctgt tccctgctct gcgtttctat tttttgtttt   4380

tcctccattt actagtagct taacactttc taacagtgtt cttattattg atacgtatct   4440

atctcttcca taagcttata aggtcacgga taatacttct cattgtagta cgtaaatgac   4500

gtgggctaga tatgagttga ataaacagtt atacctgtaa attcttacag agtgaaaata   4560

aattgttata ctttacaatt tgtttctctc tttagaccat ttccaggact tgtgattaat   4620

aaccgtgagt attttgtgaa gtgttttgtt tttgtttttt cctggggtct gacgtgtgtg   4680

cgtgtgagtg tgtatacatg cttaacgtat atcacgttac ttcacctatg tcagtaacca   4740

ggccaaatac ttgttttagc cctcagtaaa aacaccaggc acttcctagt tgtaaaatta   4800

ttcaagcttc ttaacttcct atcctcgatg cacttaatca taaaatggta ataatagcac   4860

cgattttggg ggagtcgttc cagtagatgg aaagcatctg gaacaggtgt cagcaagctc   4920

ctgccgacgt gtatgcataa agttttattg aaaccaccat cgtgtccatt tgtttatggc   4980

agaactgaga gatggcagca gcaagtgtgt gcctgcaaaa cctaaaatat ttactaattg   5040

gctctgcaag aaaagagttt gcatccccct aacctagaac agtgtctagc ctctagtatg   5100

tgtttagcct acagtatgtg ctcagcgaat acaatctata tttattactg cttttatgac   5160

tgttataatt actgtgcttg gatttcgtta caaagtaagt cacaatgtgc ctgcttctgt   5220

tagtatttca gcacagtgcc tggcacacat ggggctctca aatattgctg agcgagtgaa   5280

caaatgtcct ttcaattcct taacgttgat gtcattttca atagtatttt gagccaaact   5340

taattttgcg agtgtgtttt gttttcttaa ctttattatt aaaaatgtat aaaagtgagg   5400

ccaggcgtgg tggctcacgc ctgtaatccc agcagtttgg gaggctgagg caggcggatc   5460

agttgaggtt gggagttgga gaccagcccg tccaacatgg tgaaagcctg tctctactaa   5520

aaatacaaaa atcagctggg tgtggtggcg cgtgcctgta atcccagcta ctcaggaggc   5580

tgaggcagga gagttgcttg aatcctagag gtggaggttg cagtgagctg agatcgtgcc   5640

attgcactcc agcctgggca acaagagcaa aactctgtcc caataaataa ataaataaaa   5700

tgttctcttt tgttcctgtt cttgtgcggt agtgtggtat agagttttat ggtaattact   5760

gtgaattagt gattctgagg gacatatcag aactctgagg tttgtttcct tctcatcttg   5820

agggaaacag caaatgtatg ttaaaatgct tttccaaggg aacaacacat ccttacatta   5880

tttaaaccaa tctgcttcat tttcagagct ggttgatcag agtgagtcag aaggccccgt   5940

gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag aaataaaaga   6000

gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga cctcttccct   6060

cctaggctta aagtatcagt ggttgagaag agcttttcgg acctgttact accccaagct   6120

gtgtaatata cttgtataac agaaatacct tctatacaaa cctttttttc tacttttaga   6180

tagaaatgtc tactttttca gcagttctgt gaattaaaga gcagagtgac tgtgggtctg   6240

gaatggctgg tgtacttggg aatgtactat caggatttta cagcaatgct gggaaatgac   6300

agggaaaatg acaggaatga atctcaccag attttttatg tactcagcag agccttgagt   6360

tacggtgttt attttccaat caagtgaaga tatctcctac ttctcctact ggaacatctc   6420

agcttctgca gtgaagaaaa attcctgtga tagttcagtt ctttagtttt tctatttgaa   6480

aaaaaaaaat catttaaatg atcctttgtt cacggctctc cttaatgact gagtgaacag   6540

ttcctatctg tatatttgac taaacctttt cctaagctat ctctcatggt tcctatgttt   6600

ttttatcata attaaaagca aaaccatctg gatcacctaa cagtcagagg tcagtatctc   6660

agcgtgtgaa ttatagagga aatacagaga gaacctcttc cacttttact tttcgtccaa   6720

ataaaatgca tggtgtacca gaagttgaag atcgggttga ggattggggc tagctcgatg   6780

acactaaggc cccaacatcg cgggacctgc tgtggcgcgg attcttagga acgctgttct   6840

agccggcccc ctctccaggg gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac   6900

cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc aacctctgac   6960

gttctgcgcc ttcctaggag agtcttacat gtgttgagat ttcacaagca atgcgagttg   7020

taaaatacca gctctacaag aagctaggct ctgtgacggc atagttttca gtagctttat   7080

cacaatattc acaatggaga attatatgac atggtagcag aaataggccc ttttatgtgt   7140

tgcttctatt ttacctcaaa ttgtagatat agggtaatca ataaaatcca tccatgcctt   7200

tcacacacta agt                                                      7213


<210>  4639
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  4639

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg 
            420                 425                 430


Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe 
        435                 440                 445


Ala 



<210>  4640
<211>  4909
<212>  DNA
<213>  Homo sapiens

<400>  4640
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagctc   1860

aagctcttgg actcaccgag gcagtaaaag taccatatcc tgtgtttgaa tcaaacccgg   1920

agttcttgta tgtggaaggc ttgccagagg ggattccctt ccgaagccct acctggtttg   1980

gaattccacg acttgaaagg atcgtccgcg ggagtaataa aatcaagttc gttgttaaaa   2040

aacctgaact agttatttcc tacttgcctc ctgggatggc tagtaaaata aacactaaag   2100

ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa ttcaaaggtt cctgaaattg   2160

aggtcaccgt ggaaggccct aataacaaca atcctcaaac ctcagctgtt cgaaccccga   2220

cccagactaa cggttctaac gttcccttca agccacgagg gagagagttt tcctttgagg   2280

cctggaatgc caaaatcacg gacctaaaac agaaagttga aaatctcttc aatgagaaat   2340

gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc gttcgcgtta tttgagtctt   2400

tcccggaaga cttttatgtg gaaggcttac ctgagggtgt gccattccga agaccatcga   2460

cttttggcat tccgaggctg gagaagatac tcagaaacaa agccaaaatt aagttcatca   2520

ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag cacctcctct aagagccctc   2580

ccagaaaaat aaattcatca cccaatgtta atactactgc atcaggtgtt gaagacctta   2640

acatcattca ggtgacaatt ccagatgatg ataatgaaag actctcgaaa gttgaaaaag   2700

ctagacagct aagagaacaa gtgaatgacc tctttagtcg gaaatttggt gaagctattg   2760

gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac aattaaccct ggctgtgtgg   2820

tggttgatgg catgcccccg ggggtgtcct tcaaagcccc cagctacctg gaaatcagct   2880

ccatgagaag gatcttagac tctgccgagt ttatcaaatt cacggtcatt agaccatttc   2940

caggacttgt gattaataac cagctggttg atcagagtga gtcagaaggc cccgtgatac   3000

aagaatcagc tgaaccaagc cagttggaag ttccagccac agaaggtaaa aggacctctt   3060

ccctcctagg gtaaatcagc ttctgtgtca gggatgctgt gtggtgtcca tctgaacccc   3120

ctgcatacgc gtagctaatg tgatctcccc actttcacat aagatggtgg ccctgccttc   3180

agggaatgtg ggagccaggt gggagccttc ccggatattt aagctagaag attctacagg   3240

gagattctcc ttggatcaat atatgtctct cagtcaaaga tgtaaaagca cttttgcctt   3300

aaaaagaatg ttctgtttct aaatagagtc aacgttgtcc tcctcattgg aattcactat   3360

gagtcagaat cattagactg actttttttt ttccatagta atagtatttt gcagagtctc   3420

acagagctgc agatcttttg ttcatcttgc agagttaaca agtctgatcc tgttagtcca   3480

gatttcttaa atttggccaa gttataatag gagcagtagc ttgagacccg aagtcaggaa   3540

actttgacaa tggatttttt tttttaatcc agagacttgt actggaattt gccttaccct   3600

gtcagctcat ggacttaagg tttcatcccg ctttatgagt gcttctgaat ccaagtcatt   3660

gttacctgaa tttgcaaatt aagttgtgat attcgtgact gttaaattcc tgtaattaga   3720

ttaacctctt tgcttgcttg tttgttttct ctcctatttt agcttaaagt atcagtggtt   3780

gagaagagct tttcggacct gttactaccc caagctgtgt aatatacttg tataacagaa   3840

ataccttcta tacaaacctt tttttctact tttagataga aatgtctact ttttcagcag   3900

ttctgtgaat taaagagcag agtgactgtg ggtctggaat ggctggtgta cttgggaatg   3960

tactatcagg attttacagc aatgctggga aatgacaggg aaaatgacag gaatgaatct   4020

caccagattt tttatgtact cagcagagcc ttgagttacg gtgtttattt tccaatcaag   4080

tgaagatatc tcctacttct cctactggaa catctcagct tctgcagtga agaaaaattc   4140

ctgtgatagt tcagttcttt agtttttcta tttgaaaaaa aaaaatcatt taaatgatcc   4200

tttgttcacg gctctcctta atgactgagt gaacagttcc tatctgtata tttgactaaa   4260

ccttttccta agctatctct catggttcct atgttttttt atcataatta aaagcaaaac   4320

catctggatc acctaacagt cagaggtcag tatctcagcg tgtgaattat agaggaaata   4380

cagagagaac ctcttccact tttacttttc gtccaaataa aatgcatggt gtaccagaag   4440

ttgaagatcg ggttgaggat tggggctagc tcgatgacac taaggcccca acatcgcggg   4500

acctgctgtg gcgcggattc ttaggaacgc tgttctagcc ggccccctct ccaggggtcg   4560

ccgtggccgg cattatttcc tagttcttct tgtaaccctg aggtgccagc gcggggagtg   4620

aggaggggtc agggggctaa ggatgcaacc tctgacgttc tgcgccttcc taggagagtc   4680

ttacatgtgt tgagatttca caagcaatgc gagttgtaaa ataccagctc tacaagaagc   4740

taggctctgt gacggcatag ttttcagtag ctttatcaca atattcacaa tggagaatta   4800

tatgacatgg tagcagaaat aggccctttt atgtgttgct tctattttac ctcaaattgt   4860

agatataggg taatcaataa aatccatcca tgcctttcac acactaagt               4909


<210>  4641
<211>  829
<212>  PRT
<213>  Homo sapiens

<400>  4641

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu 
            420                 425                 430


Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu 
        435                 440                 445


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp 
    450                 455                 460


Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile 
465                 470                 475                 480


Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro 
                485                 490                 495


Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg 
            500                 505                 510


Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr 
        515                 520                 525


Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr 
    530                 535                 540


Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg 
545                 550                 555                 560


Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln 
                565                 570                 575


Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu 
            580                 585                 590


Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu 
        595                 600                 605


Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro 
    610                 615                 620


Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala 
625                 630                 635                 640


Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile 
                645                 650                 655


Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser 
            660                 665                 670


Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile 
        675                 680                 685


Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu 
    690                 695                 700


Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys 
705                 710                 715                 720


Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg 
                725                 730                 735


Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro 
            740                 745                 750


Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg 
        755                 760                 765


Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro 
    770                 775                 780


Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser 
785                 790                 795                 800


Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val 
                805                 810                 815


Pro Ala Thr Glu Gly Lys Arg Thr Ser Ser Leu Leu Gly 
            820                 825


<210>  4642
<211>  5096
<212>  DNA
<213>  Homo sapiens

<400>  4642
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2040

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2100

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2160

tgaatcaaac ccggagttct tgaaaggatc gtccgcggga gtaataaaat caagttcgtt   2220

gttaaaaaac ctgaactagt tatttcctac ttgcctcctg ggatggctag taaaataaac   2280

actaaagctt tgcagtcccc caaaagacca cgaagtcctg ggagtaattc aaaggttcct   2340

gaaattgagg tcaccgtgga aggccctaat aacaacaatc ctcaaacctc agctgttcga   2400

accccgaccc agactaacgg ttctaacgtt cccttcaagc cacgagggag agagttttcc   2460

tttgaggcct ggaatgccaa aatcacggac ctaaaacaga aagttgaaaa tctcttcaat   2520

gagaaatgtg gggaagctct tggccttaaa caagctgtga aggtgccgtt cgcgttattt   2580

gagtctttcc cggaagactt ttatgtggaa ggcttacctg agggtgtgcc attccgaaga   2640

ccatcgactt ttggcattcc gaggctggag aagatactca gaaacaaagc caaaattaag   2700

ttcatcatta aaaagcccga aatgtttgag acggcgatta aggagagcac ctcctctaag   2760

agccctccca gaaaaataaa ttcatcaccc aatgttaata ctactgcatc aggtgttgaa   2820

gaccttaaca tcattcaggt gacaattcca gatgatgata atgaaagact ctcgaaagtt   2880

gaaaaagcta gacagctaag agaacaagtg aatgacctct ttagtcggaa atttggtgaa   2940

gctattggta tgggttttcc tgtgaaagtt ccctacagga aaatcacaat taaccctggc   3000

tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca aagcccccag ctacctggaa   3060

atcagctcca tgagaaggat cttagactct gccgagttta tcaaattcac ggtcattaga   3120

ccatttccag gacttgtgat taataaccag ctggttgatc agagtgagtc agaaggcccc   3180

gtgatacaag aatcagctga accaagccag ttggaagttc cagccacaga aggtaaaagg   3240

acctcttccc tcctagggta aatcagcttc tgtgtcaggg atgctgtgtg gtgtccatct   3300

gaaccccctg catacgcgta gctaatgtga tctccccact ttcacataag atggtggccc   3360

tgccttcagg gaatgtggga gccaggtggg agccttcccg gatatttaag ctagaagatt   3420

ctacagggag attctccttg gatcaatata tgtctctcag tcaaagatgt aaaagcactt   3480

ttgccttaaa aagaatgttc tgtttctaaa tagagtcaac gttgtcctcc tcattggaat   3540

tcactatgag tcagaatcat tagactgact tttttttttc catagtaata gtattttgca   3600

gagtctcaca gagctgcaga tcttttgttc atcttgcaga gttaacaagt ctgatcctgt   3660

tagtccagat ttcttaaatt tggccaagtt ataataggag cagtagcttg agacccgaag   3720

tcaggaaact ttgacaatgg attttttttt ttaatccaga gacttgtact ggaatttgcc   3780

ttaccctgtc agctcatgga cttaaggttt catcccgctt tatgagtgct tctgaatcca   3840

agtcattgtt acctgaattt gcaaattaag ttgtgatatt cgtgactgtt aaattcctgt   3900

aattagatta acctctttgc ttgcttgttt gttttctctc ctattttagc ttaaagtatc   3960

agtggttgag aagagctttt cggacctgtt actaccccaa gctgtgtaat atacttgtat   4020

aacagaaata ccttctatac aaaccttttt ttctactttt agatagaaat gtctactttt   4080

tcagcagttc tgtgaattaa agagcagagt gactgtgggt ctggaatggc tggtgtactt   4140

gggaatgtac tatcaggatt ttacagcaat gctgggaaat gacagggaaa atgacaggaa   4200

tgaatctcac cagatttttt atgtactcag cagagccttg agttacggtg tttattttcc   4260

aatcaagtga agatatctcc tacttctcct actggaacat ctcagcttct gcagtgaaga   4320

aaaattcctg tgatagttca gttctttagt ttttctattt gaaaaaaaaa aatcatttaa   4380

atgatccttt gttcacggct ctccttaatg actgagtgaa cagttcctat ctgtatattt   4440

gactaaacct tttcctaagc tatctctcat ggttcctatg tttttttatc ataattaaaa   4500

gcaaaaccat ctggatcacc taacagtcag aggtcagtat ctcagcgtgt gaattataga   4560

ggaaatacag agagaacctc ttccactttt acttttcgtc caaataaaat gcatggtgta   4620

ccagaagttg aagatcgggt tgaggattgg ggctagctcg atgacactaa ggccccaaca   4680

tcgcgggacc tgctgtggcg cggattctta ggaacgctgt tctagccggc cccctctcca   4740

ggggtcgccg tggccggcat tatttcctag ttcttcttgt aaccctgagg tgccagcgcg   4800

gggagtgagg aggggtcagg gggctaagga tgcaacctct gacgttctgc gccttcctag   4860

gagagtctta catgtgttga gatttcacaa gcaatgcgag ttgtaaaata ccagctctac   4920

aagaagctag gctctgtgac ggcatagttt tcagtagctt tatcacaata ttcacaatgg   4980

agaattatat gacatggtag cagaaatagg cccttttatg tgttgcttct attttacctc   5040

aaattgtaga tatagggtaa tcaataaaat ccatccatgc ctttcacaca ctaagt       5096


<210>  4643
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  4643

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala 
            580                 585                 590


Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600                 605


<210>  4644
<211>  4372
<212>  DNA
<213>  Homo sapiens

<400>  4644
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1980

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   2040

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttga   2100

aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg aactagttat   2160

ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc agtcccccaa   2220

aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg   2280

ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga ctaacggttc   2340

taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga atgccaaaat   2400

cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg   2460

ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg aagactttta   2520

tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg gcattccgag   2580

gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa agcccgaaat   2640

gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa aaataaattc   2700

atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca ttcaggtgac   2760

aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac agctaagaga   2820

acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg gttttcctgt   2880

gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg atggcatgcc   2940

cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga gaaggatctt   3000

agactctgcc gagtttatca aattcacggt cattagacca tttccaggac ttgtgattaa   3060

taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat cagctgaacc   3120

aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa gctctcagat   3180

caagcaagaa ccagacccca cgtggtagac ctcttccctc ctaggcttaa agtatcagtg   3240

gttgagaaga gcttttcgga cctgttacta ccccaagctg tgtaatatac ttgtataaca   3300

gaaatacctt ctatacaaac ctttttttct acttttagat agaaatgtct actttttcag   3360

cagttctgtg aattaaagag cagagtgact gtgggtctgg aatggctggt gtacttggga   3420

atgtactatc aggattttac agcaatgctg ggaaatgaca gggaaaatga caggaatgaa   3480

tctcaccaga ttttttatgt actcagcaga gccttgagtt acggtgttta ttttccaatc   3540

aagtgaagat atctcctact tctcctactg gaacatctca gcttctgcag tgaagaaaaa   3600

ttcctgtgat agttcagttc tttagttttt ctatttgaaa aaaaaaaatc atttaaatga   3660

tcctttgttc acggctctcc ttaatgactg agtgaacagt tcctatctgt atatttgact   3720

aaaccttttc ctaagctatc tctcatggtt cctatgtttt tttatcataa ttaaaagcaa   3780

aaccatctgg atcacctaac agtcagaggt cagtatctca gcgtgtgaat tatagaggaa   3840

atacagagag aacctcttcc acttttactt ttcgtccaaa taaaatgcat ggtgtaccag   3900

aagttgaaga tcgggttgag gattggggct agctcgatga cactaaggcc ccaacatcgc   3960

gggacctgct gtggcgcgga ttcttaggaa cgctgttcta gccggccccc tctccagggg   4020

tcgccgtggc cggcattatt tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga   4080

gtgaggaggg gtcagggggc taaggatgca acctctgacg ttctgcgcct tcctaggaga   4140

gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt aaaataccag ctctacaaga   4200

agctaggctc tgtgacggca tagttttcag tagctttatc acaatattca caatggagaa   4260

ttatatgaca tggtagcaga aataggccct tttatgtgtt gcttctattt tacctcaaat   4320

tgtagatata gggtaatcaa taaaatccat ccatgccttt cacacactaa gt           4372


<210>  4645
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  4645

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
                565                 570                 575


Ser Ser Leu Leu Lys Asn Leu Asn 
            580


<210>  4646
<211>  4984
<212>  DNA
<213>  Homo sapiens

<400>  4646
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agctcaagct cttggactca ccgaggcagt aaaagtacca tatcctgtgt   1980

ttgaatcaaa cccggagttc ttgtatgtgg aaggcttgcc agaggggatt cccttccgaa   2040

gccctacctg gtttggaatt ccacgacttg aaaggatcgt ccgcgggagt aataaaatca   2100

agttcgttgt taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta   2160

aaataaacac taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa   2220

aggttcctga aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag   2280

ctgttcgaac cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag   2340

agttttcctt tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc   2400

tcttcaatga gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg   2460

cgttatttga gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat   2520

tccgaagacc atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca   2580

aaattaagtt catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct   2640

cctctaagag ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag   2700

gtgttgaaga ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct   2760

cgaaagttga aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat   2820

ttggtgaagc tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta   2880

accctggctg tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct   2940

acctggaaat cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg   3000

tcattagacc atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag   3060

aaggccccgt gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag   3120

gtaaaaggac ctcttccctc ctagggtaaa tcagcttctg tgtcagggat gctgtgtggt   3180

gtccatctga accccctgca tacgcgtagc taatgtgatc tccccacttt cacataagat   3240

ggtggccctg ccttcaggga atgtgggagc caggtgggag ccttcccgga tatttaagct   3300

agaagattct acagggagat tctccttgga tcaatatatg tctctcagtc aaagatgtaa   3360

aagcactttt gccttaaaaa gaatgttctg tttctaaata gagtcaacgt tgtcctcctc   3420

attggaattc actatgagtc agaatcatta gactgacttt tttttttcca tagtaatagt   3480

attttgcaga gtctcacaga gctgcagatc ttttgttcat cttgcagagt taacaagtct   3540

gatcctgtta gtccagattt cttaaatttg gccaagttat aataggagca gtagcttgag   3600

acccgaagtc aggaaacttt gacaatggat tttttttttt aatccagaga cttgtactgg   3660

aatttgcctt accctgtcag ctcatggact taaggtttca tcccgcttta tgagtgcttc   3720

tgaatccaag tcattgttac ctgaatttgc aaattaagtt gtgatattcg tgactgttaa   3780

attcctgtaa ttagattaac ctctttgctt gcttgtttgt tttctctcct attttagctt   3840

aaagtatcag tggttgagaa gagcttttcg gacctgttac taccccaagc tgtgtaatat   3900

acttgtataa cagaaatacc ttctatacaa accttttttt ctacttttag atagaaatgt   3960

ctactttttc agcagttctg tgaattaaag agcagagtga ctgtgggtct ggaatggctg   4020

gtgtacttgg gaatgtacta tcaggatttt acagcaatgc tgggaaatga cagggaaaat   4080

gacaggaatg aatctcacca gattttttat gtactcagca gagccttgag ttacggtgtt   4140

tattttccaa tcaagtgaag atatctccta cttctcctac tggaacatct cagcttctgc   4200

agtgaagaaa aattcctgtg atagttcagt tctttagttt ttctatttga aaaaaaaaaa   4260

tcatttaaat gatcctttgt tcacggctct ccttaatgac tgagtgaaca gttcctatct   4320

gtatatttga ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt tttttatcat   4380

aattaaaagc aaaaccatct ggatcaccta acagtcagag gtcagtatct cagcgtgtga   4440

attatagagg aaatacagag agaacctctt ccacttttac ttttcgtcca aataaaatgc   4500

atggtgtacc agaagttgaa gatcgggttg aggattgggg ctagctcgat gacactaagg   4560

ccccaacatc gcgggacctg ctgtggcgcg gattcttagg aacgctgttc tagccggccc   4620

cctctccagg ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa ccctgaggtg   4680

ccagcgcggg gagtgaggag gggtcagggg gctaaggatg caacctctga cgttctgcgc   4740

cttcctagga gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc   4800

agctctacaa gaagctaggc tctgtgacgg catagttttc agtagcttta tcacaatatt   4860

cacaatggag aattatatga catggtagca gaaataggcc cttttatgtg ttgcttctat   4920

tttacctcaa attgtagata tagggtaatc aataaaatcc atccatgcct ttcacacact   4980

aagt                                                                4984


<210>  4647
<211>  854
<212>  PRT
<213>  Homo sapiens

<400>  4647

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro 
    450                 455                 460


Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu 
465                 470                 475                 480


Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu 
                485                 490                 495


Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro 
            500                 505                 510


Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn 
        515                 520                 525


Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn 
    530                 535                 540


Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn 
545                 550                 555                 560


Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser 
                565                 570                 575


Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp 
            580                 585                 590


Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn 
        595                 600                 605


Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro 
    610                 615                 620


Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu 
625                 630                 635                 640


Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg 
                645                 650                 655


Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys 
            660                 665                 670


Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys 
        675                 680                 685


Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala 
    690                 695                 700


Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp 
705                 710                 715                 720


Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu 
                725                 730                 735


Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met 
            740                 745                 750


Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly 
        755                 760                 765


Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro 
    770                 775                 780


Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu 
785                 790                 795                 800


Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn 
                805                 810                 815


Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu 
            820                 825                 830


Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Gly Lys Arg 
        835                 840                 845


Thr Ser Ser Leu Leu Gly 
    850


<210>  4648
<211>  5323
<212>  DNA
<213>  Homo sapiens

<400>  4648
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   2040

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2100

gaaatttgct tagatttgtt gacagcggtt tcctggagtg ctgtcttgag aacgattctg   2160

aggaggctca gcaagaaaga gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa   2220

ctcaagctct tggactcacc gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc   2280

cggagttctt gtatgtggaa ggcttgccag aggggattcc cttccgaagc cctacctggt   2340

ttggaattcc acgacttgaa aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta   2400

aaaaacctga actagttatt tcctacttgc ctcctgggat ggctagtaaa ataaacacta   2460

aagctttgca gtcccccaaa agaccacgaa gtcctgggag taattcaaag gttcctgaaa   2520

ttgaggtcac cgtggaaggc cctaataaca acaatcctca aacctcagct gttcgaaccc   2580

cgacccagac taacggttct aacgttccct tcaagccacg agggagagag ttttcctttg   2640

aggcctggaa tgccaaaatc acggacctaa aacagaaagt tgaaaatctc ttcaatgaga   2700

aatgtgggga agctcttggc cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt   2760

ctttcccgga agacttttat gtggaaggct tacctgaggg tgtgccattc cgaagaccat   2820

cgacttttgg cattccgagg ctggagaaga tactcagaaa caaagccaaa attaagttca   2880

tcattaaaaa gcccgaaatg tttgagacgg cgattaagga gagcacctcc tctaagagcc   2940

ctcccagaaa aataaattca tcacccaatg ttaatactac tgcatcaggt gttgaagacc   3000

ttaacatcat tcaggtgaca attccagatg atgataatga aagactctcg aaagttgaaa   3060

aagctagaca gctaagagaa caagtgaatg acctctttag tcggaaattt ggtgaagcta   3120

ttggtatggg ttttcctgtg aaagttccct acaggaaaat cacaattaac cctggctgtg   3180

tggtggttga tggcatgccc ccgggggtgt ccttcaaagc ccccagctac ctggaaatca   3240

gctccatgag aaggatctta gactctgccg agtttatcaa attcacggtc attagaccat   3300

ttccaggact tgtgattaat aaccagctgg ttgatcagag tgagtcagaa ggccccgtga   3360

tacaagaatc agctgaacca agccagttgg aagttccagc cacagaagaa ataaaagaga   3420

ctgatggaag ctctcagatc aagcaagaac cagaccccac gtggtagacc tcttccctcc   3480

tagggtaaat cagcttctgt gtcagggatg ctgtgtggtg tccatctgaa ccccctgcat   3540

acgcgtagct aatgtgatct ccccactttc acataagatg gtggccctgc cttcagggaa   3600

tgtgggagcc aggtgggagc cttcccggat atttaagcta gaagattcta cagggagatt   3660

ctccttggat caatatatgt ctctcagtca aagatgtaaa agcacttttg ccttaaaaag   3720

aatgttctgt ttctaaatag agtcaacgtt gtcctcctca ttggaattca ctatgagtca   3780

gaatcattag actgactttt ttttttccat agtaatagta ttttgcagag tctcacagag   3840

ctgcagatct tttgttcatc ttgcagagtt aacaagtctg atcctgttag tccagatttc   3900

ttaaatttgg ccaagttata ataggagcag tagcttgaga cccgaagtca ggaaactttg   3960

acaatggatt ttttttttta atccagagac ttgtactgga atttgcctta ccctgtcagc   4020

tcatggactt aaggtttcat cccgctttat gagtgcttct gaatccaagt cattgttacc   4080

tgaatttgca aattaagttg tgatattcgt gactgttaaa ttcctgtaat tagattaacc   4140

tctttgcttg cttgtttgtt ttctctccta ttttagctta aagtatcagt ggttgagaag   4200

agcttttcgg acctgttact accccaagct gtgtaatata cttgtataac agaaatacct   4260

tctatacaaa cctttttttc tacttttaga tagaaatgtc tactttttca gcagttctgt   4320

gaattaaaga gcagagtgac tgtgggtctg gaatggctgg tgtacttggg aatgtactat   4380

caggatttta cagcaatgct gggaaatgac agggaaaatg acaggaatga atctcaccag   4440

attttttatg tactcagcag agccttgagt tacggtgttt attttccaat caagtgaaga   4500

tatctcctac ttctcctact ggaacatctc agcttctgca gtgaagaaaa attcctgtga   4560

tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat catttaaatg atcctttgtt   4620

cacggctctc cttaatgact gagtgaacag ttcctatctg tatatttgac taaacctttt   4680

cctaagctat ctctcatggt tcctatgttt ttttatcata attaaaagca aaaccatctg   4740

gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa ttatagagga aatacagaga   4800

gaacctcttc cacttttact tttcgtccaa ataaaatgca tggtgtacca gaagttgaag   4860

atcgggttga ggattggggc tagctcgatg acactaaggc cccaacatcg cgggacctgc   4920

tgtggcgcgg attcttagga acgctgttct agccggcccc ctctccaggg gtcgccgtgg   4980

ccggcattat ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg   5040

ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc ttcctaggag agtcttacat   5100

gtgttgagat ttcacaagca atgcgagttg taaaatacca gctctacaag aagctaggct   5160

ctgtgacggc atagttttca gtagctttat cacaatattc acaatggaga attatatgac   5220

atggtagcag aaataggccc ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat   5280

agggtaatca ataaaatcca tccatgcctt tcacacacta agt                     5323


<210>  4649
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  4649

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala 



<210>  4650
<211>  4362
<212>  DNA
<213>  Homo sapiens

<400>  4650
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   2040

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   2100

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2160

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2220

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2280

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2340

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2400

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2460

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2520

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2580

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2640

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2700

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2760

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2820

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2880

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2940

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   3000

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   3060

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3120

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3180

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3240

ttcacggtca ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt   3300

gagtcagaag gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc   3360

acagaagaaa taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg   3420

tggtagacct cttccctcct aggcttaaag tatcagtggt tgagaagagc ttttcggacc   3480

tgttactacc ccaagctgta gccttgagtt acggtgttta ttttccaatc aagtgaagat   3540

atctcctact tctcctactg gaacatctca gcttctgcag tgaagaaaaa ttcctgtgat   3600

agttcagttc tttagttttt ctatttgaaa aaaaaaaatc atttaaatga tcctttgttc   3660

acggctctcc ttaatgactg agtgaacagt tcctatctgt atatttgact aaaccttttc   3720

ctaagctatc tctcatggtt cctatgtttt tttatcataa ttaaaagcaa aaccatctgg   3780

atcacctaac agtcagaggt cagtatctca gcgtgtgaat tatagaggaa atacagagag   3840

aacctcttcc acttttactt ttcgtccaaa taaaatgcat ggtgtaccag aagttgaaga   3900

tcgggttgag gattggggct agctcgatga cactaaggcc ccaacatcgc gggacctgct   3960

gtggcgcgga ttcttaggaa cgctgttcta gccggccccc tctccagggg tcgccgtggc   4020

cggcattatt tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga gtgaggaggg   4080

gtcagggggc taaggatgca acctctgacg ttctgcgcct tcctaggaga gtcttacatg   4140

tgttgagatt tcacaagcaa tgcgagttgt aaaataccag ctctacaaga agctaggctc   4200

tgtgacggca tagttttcag tagctttatc acaatattca caatggagaa ttatatgaca   4260

tggtagcaga aataggccct tttatgtgtt gcttctattt tacctcaaat tgtagatata   4320

gggtaatcaa taaaatccat ccatgccttt cacacactaa gt                      4362


<210>  4651
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  4651

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
465                 470                 475                 480


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
                485                 490                 495


<210>  4652
<211>  3716
<212>  DNA
<213>  Homo sapiens

<400>  4652
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagctc   1860

aagctcttgg actcaccgag gcagtaaaag taccatatcc tgtgtttgaa tcaaacccgg   1920

agttcttgta tgtggaaggc ttgccagagg ggattccctt ccgaagccct acctggtttg   1980

gaattccacg acttgaaagg atcgtccgcg ggagtaataa aatcaagttc gttgttaaaa   2040

aacctgaact agttatttcc tacttgcctc ctgggatggc tagtaaaata aacactaaag   2100

ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa ttcaaaggtt cctgaaattg   2160

aggtcaccgt ggaaggccct aataacaaca atcctcaaac ctcagctgtt cgaaccccga   2220

cccagactaa cggttctaac gttcccttca agccacgagg gagagagttt tcctttgagg   2280

cctggaatgc caaaatcacg gacctaaaac agaaagttga aaatctcttc aatgagaaat   2340

gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc gttcgcgtta tttgagtctt   2400

tcccggaaga cttttatgtg gaaggcttac ctgagggtgt gccattccga agaccatcga   2460

cttttggcat tccgaggctg gagaagatac tcagaaacaa agccaaaatt aagttcatca   2520

ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag cacctcctct aagagccctc   2580

ccagaaaaat aaattcatca cccaatgtta atactactgc atcaggtgtt gaagacctta   2640

acatcattca ggtgacaatt ccagatgatg ataatgaaag actctcgaaa gttgaaaaag   2700

ctagacagct aagagaacaa gtgaatgacc tctttagtcg gaaatttggt gaagctattg   2760

gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac aattaaccct ggctgtgtgg   2820

tggttgatgg catgcccccg ggggtgtcct tcaaagcccc cagctacctg gaaatcagct   2880

ccatgagaag gatcttagac tctgccgagt ttatcaaatt cacggtcatt agaccatttc   2940

caggacttgt gattaataac cagctggttg atcagagtga gtcagaaggc cccgtgatac   3000

aagaatcagc tgaaccaagc cagttggaag ttccagccac agaagaaata aaagagactg   3060

atggaagctc tcagatcaag caagaaccag accccacgtg gtagacctct tccctcctag   3120

gcaaaaccat ctggatcacc taacagtcag aggtcagtat ctcagcgtgt gaattataga   3180

ggaaatacag agagaacctc ttccactttt acttttcgtc caaataaaat gcatggtgta   3240

ccagaagttg aagatcgggt tgaggattgg ggctagctcg atgacactaa ggccccaaca   3300

tcgcgggacc tgctgtggcg cggattctta ggaacgctgt tctagccggc cccctctcca   3360

ggggtcgccg tggccggcat tatttcctag ttcttcttgt aaccctgagg tgccagcgcg   3420

gggagtgagg aggggtcagg gggctaagga tgcaacctct gacgttctgc gccttcctag   3480

gagagtctta catgtgttga gatttcacaa gcaatgcgag ttgtaaaata ccagctctac   3540

aagaagctag gctctgtgac ggcatagttt tcagtagctt tatcacaata ttcacaatgg   3600

agaattatat gacatggtag cagaaatagg cccttttatg tgttgcttct attttacctc   3660

aaattgtaga tatagggtaa tcaataaaat ccatccatgc ctttcacaca ctaagt       3716


<210>  4653
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  4653

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu 
            420                 425                 430


Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu 
        435                 440                 445


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp 
    450                 455                 460


Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile 
465                 470                 475                 480


Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro 
                485                 490                 495


Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg 
            500                 505                 510


Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr 
        515                 520                 525


Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr 
    530                 535                 540


Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg 
545                 550                 555                 560


Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln 
                565                 570                 575


Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu 
            580                 585                 590


Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu 
        595                 600                 605


Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro 
    610                 615                 620


Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala 
625                 630                 635                 640


Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile 
                645                 650                 655


Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser 
            660                 665                 670


Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile 
        675                 680                 685


Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu 
    690                 695                 700


Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys 
705                 710                 715                 720


Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg 
                725                 730                 735


Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro 
            740                 745                 750


Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg 
        755                 760                 765


Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro 
    770                 775                 780


Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser 
785                 790                 795                 800


Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val 
                805                 810                 815


Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys 
            820                 825                 830


Gln Glu Pro Asp Pro Thr Trp 
        835


<210>  4654
<211>  5040
<212>  DNA
<213>  Homo sapiens

<400>  4654
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1980

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   2040

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   2100

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2160

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2220

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2280

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2340

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2400

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2460

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2520

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2580

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2640

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2700

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2760

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2820

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2880

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2940

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   3000

cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg atcagagtga   3060

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   3120

agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag accccacgtg   3180

gtagacctct tccctcctag ggtaaatcag cttctgtgtc agggatgctg tgtggtgtcc   3240

atctgaaccc cctgcatacg cgtagctaat gtgatctccc cactttcaca taagatggtg   3300

gccctgcctt cagggaatgt gggagccagg tgggagcctt cccggatatt taagctagaa   3360

gattctacag ggagattctc cttggatcaa tatatgtctc tcagtcaaag atgtaaaagc   3420

acttttgcct taaaaagaat gttctgtttc taaatagagt caacgttgtc ctcctcattg   3480

gaattcacta tgagtcagaa tcattagact gacttttttt tttccatagt aatagtattt   3540

tgcagagtct cacagagctg cagatctttt gttcatcttg cagagttaac aagtctgatc   3600

ctgttagtcc agatttctta aatttggcca agttataata ggagcagtag cttgagaccc   3660

gaagtcagga aactttgaca atggattttt ttttttaatc cagagacttg tactggaatt   3720

tgccttaccc tgtcagctca tggacttaag gtttcatccc gctttatgag tgcttctgaa   3780

tccaagtcat tgttacctga atttgcaaat taagttgtga tattcgtgac tgttaaattc   3840

ctgtaattag attaacctct ttgcttgctt gtttgttttc tctcctattt tagcttaaag   3900

tatcagtggt tgagaagagc ttttcggacc tgttactacc ccaagctgtg taatatactt   3960

gtataacaga aataccttct atacaaacct ttttttctac ttttagatag aaatgtctac   4020

tttttcagca gttctgtgaa ttaaagagca gagtgactgt gggtctggaa tggctggtgt   4080

acttgggaat gtactatcag gattttacag caatgctggg aaatgacagg gaaaatgaca   4140

ggaatgaatc tcaccagatt ttttatgtac tcagcagagc cttgagttac ggtgtttatt   4200

ttccaatcaa gtgaagatat ctcctacttc tcctactgga acatctcagc ttctgcagtg   4260

aagaaaaatt cctgtgatag ttcagttctt tagtttttct atttgaaaaa aaaaaatcat   4320

ttaaatgatc ctttgttcac ggctctcctt aatgactgag tgaacagttc ctatctgtat   4380

atttgactaa accttttcct aagctatctc tcatggttcc tatgtttttt tatcataatt   4440

aaaagcaaaa ccatctggat cacctaacag tcagaggtca gtatctcagc gtgtgaatta   4500

tagaggaaat acagagagaa cctcttccac ttttactttt cgtccaaata aaatgcatgg   4560

tgtaccagaa gttgaagatc gggttgagga ttggggctag ctcgatgaca ctaaggcccc   4620

aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg ctgttctagc cggccccctc   4680

tccaggggtc gccgtggccg gcattatttc ctagttcttc ttgtaaccct gaggtgccag   4740

cgcggggagt gaggaggggt cagggggcta aggatgcaac ctctgacgtt ctgcgccttc   4800

ctaggagagt cttacatgtg ttgagatttc acaagcaatg cgagttgtaa aataccagct   4860

ctacaagaag ctaggctctg tgacggcata gttttcagta gctttatcac aatattcaca   4920

atggagaatt atatgacatg gtagcagaaa taggcccttt tatgtgttgc ttctatttta   4980

cctcaaattg tagatatagg gtaatcaata aaatccatcc atgcctttca cacactaagt   5040


<210>  4655
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  4655

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
    450                 455                 460


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
465                 470                 475                 480


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
                485                 490                 495


Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys 
            500                 505                 510


Asn Leu Asn 
        515


<210>  4656
<211>  4127
<212>  DNA
<213>  Homo sapiens

<400>  4656
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   2040

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2100

taccatatcc tgtgtttgaa tcaaacccgg agttcttgaa aggatcgtcc gcgggagtaa   2160

taaaatcaag ttcgttgtta aaaaacctga actagttatt tcctacttgc ctcctgggat   2220

ggctagtaaa ataaacacta aagctttgca gtcccccaaa agaccacgaa gtcctgggag   2280

taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc cctaataaca acaatcctca   2340

aacctcagct gttcgaaccc cgacccagac taacggttct aacgttccct tcaagccacg   2400

agggagagag ttttcctttg aggcctggaa tgccaaaatc acggacctaa aacagaaagt   2460

tgaaaatctc ttcaatgaga aatgtgggga agctcttggc cttaaacaag ctgtgaaggt   2520

gccgttcgcg ttatttgagt ctttcccgga agacttttat gtggaaggct tacctgaggg   2580

tgtgccattc cgaagaccat cgacttttgg cattccgagg ctggagaaga tactcagaaa   2640

caaagccaaa attaagttca tcattaaaaa gcccgaaatg tttgagacgg cgattaagga   2700

gagcacctcc tctaagagcc ctcccagaaa aataaattca tcacccaatg ttaatactac   2760

tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca attccagatg atgataatga   2820

aagactctcg aaagttgaaa aagctagaca gctaagagaa caagtgaatg acctctttag   2880

tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg aaagttccct acaggaaaat   2940

cacaattaac cctggctgtg tggtggttga tggcatgccc ccgggggtgt ccttcaaagc   3000

ccccagctac ctggaaatca gctccatgag aaggatctta gactctgccg agtttatcaa   3060

attcacggtc attagaccat ttccaggact tgtgattaat aaccagctgg ttgatcagag   3120

tgagtcagaa ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc   3180

cacagaagaa ataaaagaga ctgatggaag ctctcagatc aagcaagaac cagaccccac   3240

gtggtagacc tcttccctcc taggagcctt gagttacggt gtttattttc caatcaagtg   3300

aagatatctc ctacttctcc tactggaaca tctcagcttc tgcagtgaag aaaaattcct   3360

gtgatagttc agttctttag tttttctatt tgaaaaaaaa aaatcattta aatgatcctt   3420

tgttcacggc tctccttaat gactgagtga acagttccta tctgtatatt tgactaaacc   3480

ttttcctaag ctatctctca tggttcctat gtttttttat cataattaaa agcaaaacca   3540

tctggatcac ctaacagtca gaggtcagta tctcagcgtg tgaattatag aggaaataca   3600

gagagaacct cttccacttt tacttttcgt ccaaataaaa tgcatggtgt accagaagtt   3660

gaagatcggg ttgaggattg gggctagctc gatgacacta aggccccaac atcgcgggac   3720

ctgctgtggc gcggattctt aggaacgctg ttctagccgg ccccctctcc aggggtcgcc   3780

gtggccggca ttatttccta gttcttcttg taaccctgag gtgccagcgc ggggagtgag   3840

gaggggtcag ggggctaagg atgcaacctc tgacgttctg cgccttccta ggagagtctt   3900

acatgtgttg agatttcaca agcaatgcga gttgtaaaat accagctcta caagaagcta   3960

ggctctgtga cggcatagtt ttcagtagct ttatcacaat attcacaatg gagaattata   4020

tgacatggta gcagaaatag gcccttttat gtgttgcttc tattttacct caaattgtag   4080

atatagggta atcaataaaa tccatccatg cctttcacac actaagt                 4127


<210>  4657
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  4657

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
465                 470                 475                 480


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
                485                 490                 495


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
            500                 505                 510


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
        515                 520                 525


Ser Ser Leu Leu Lys Asn Leu Asn 
    530                 535


<210>  4658
<211>  4980
<212>  DNA
<213>  Homo sapiens

<400>  4658
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1980

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   2040

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2100

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2160

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2220

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2280

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2340

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2400

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2460

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2520

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2580

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2640

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2700

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2760

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2820

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2880

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   2940

cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg atcagagtga   3000

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   3060

agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag accccacgtg   3120

gtagacctct tccctcctag ggtaaatcag cttctgtgtc agggatgctg tgtggtgtcc   3180

atctgaaccc cctgcatacg cgtagctaat gtgatctccc cactttcaca taagatggtg   3240

gccctgcctt cagggaatgt gggagccagg tgggagcctt cccggatatt taagctagaa   3300

gattctacag ggagattctc cttggatcaa tatatgtctc tcagtcaaag atgtaaaagc   3360

acttttgcct taaaaagaat gttctgtttc taaatagagt caacgttgtc ctcctcattg   3420

gaattcacta tgagtcagaa tcattagact gacttttttt tttccatagt aatagtattt   3480

tgcagagtct cacagagctg cagatctttt gttcatcttg cagagttaac aagtctgatc   3540

ctgttagtcc agatttctta aatttggcca agttataata ggagcagtag cttgagaccc   3600

gaagtcagga aactttgaca atggattttt ttttttaatc cagagacttg tactggaatt   3660

tgccttaccc tgtcagctca tggacttaag gtttcatccc gctttatgag tgcttctgaa   3720

tccaagtcat tgttacctga atttgcaaat taagttgtga tattcgtgac tgttaaattc   3780

ctgtaattag attaacctct ttgcttgctt gtttgttttc tctcctattt tagcttaaag   3840

tatcagtggt tgagaagagc ttttcggacc tgttactacc ccaagctgtg taatatactt   3900

gtataacaga aataccttct atacaaacct ttttttctac ttttagatag aaatgtctac   3960

tttttcagca gttctgtgaa ttaaagagca gagtgactgt gggtctggaa tggctggtgt   4020

acttgggaat gtactatcag gattttacag caatgctggg aaatgacagg gaaaatgaca   4080

ggaatgaatc tcaccagatt ttttatgtac tcagcagagc cttgagttac ggtgtttatt   4140

ttccaatcaa gtgaagatat ctcctacttc tcctactgga acatctcagc ttctgcagtg   4200

aagaaaaatt cctgtgatag ttcagttctt tagtttttct atttgaaaaa aaaaaatcat   4260

ttaaatgatc ctttgttcac ggctctcctt aatgactgag tgaacagttc ctatctgtat   4320

atttgactaa accttttcct aagctatctc tcatggttcc tatgtttttt tatcataatt   4380

aaaagcaaaa ccatctggat cacctaacag tcagaggtca gtatctcagc gtgtgaatta   4440

tagaggaaat acagagagaa cctcttccac ttttactttt cgtccaaata aaatgcatgg   4500

tgtaccagaa gttgaagatc gggttgagga ttggggctag ctcgatgaca ctaaggcccc   4560

aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg ctgttctagc cggccccctc   4620

tccaggggtc gccgtggccg gcattatttc ctagttcttc ttgtaaccct gaggtgccag   4680

cgcggggagt gaggaggggt cagggggcta aggatgcaac ctctgacgtt ctgcgccttc   4740

ctaggagagt cttacatgtg ttgagatttc acaagcaatg cgagttgtaa aataccagct   4800

ctacaagaag ctaggctctg tgacggcata gttttcagta gctttatcac aatattcaca   4860

atggagaatt atatgacatg gtagcagaaa taggcccttt tatgtgttgc ttctatttta   4920

cctcaaattg tagatatagg gtaatcaata aaatccatcc atgcctttca cacactaagt   4980


<210>  4659
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  4659

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
            420                 425                 430


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
        435                 440                 445


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
    450                 455                 460


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser 
465                 470                 475                 480


Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
                485                 490                 495


<210>  4660
<211>  4459
<212>  DNA
<213>  Homo sapiens

<400>  4660
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   1980

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2040

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2100

atcaaacccg gagttcttgt atgtggaagg cttgccagag gggattccct tccgaagccc   2160

tacctggttt ggaattccac gacttgaaag gatcgtccgc gggagtaata aaatcaagtt   2220

cgttgttaaa aaacctgaac tagttatttc ctacttgcct cctgggatgg ctagtaaaat   2280

aaacactaaa gctttgcagt cccccaaaag accacgaagt cctgggagta attcaaaggt   2340

tcctgaaatt gaggtcaccg tggaaggccc taataacaac aatcctcaaa cctcagctgt   2400

tcgaaccccg acccagacta acggttctaa cgttcccttc aagccacgag ggagagagtt   2460

ttcctttgag gcctggaatg ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt   2520

caatgagaaa tgtggggaag ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt   2580

atttgagtct ttcccggaag acttttatgt ggaaggctta cctgagggtg tgccattccg   2640

aagaccatcg acttttggca ttccgaggct ggagaagata ctcagaaaca aagccaaaat   2700

taagttcatc attaaaaagc ccgaaatgtt tgagacggcg attaaggaga gcacctcctc   2760

taagagccct cccagaaaaa taaattcatc acccaatgtt aatactactg catcaggtgt   2820

tgaagacctt aacatcattc aggtgacaat tccagatgat gataatgaaa gactctcgaa   2880

agttgaaaaa gctagacagc taagagaaca agtgaatgac ctctttagtc ggaaatttgg   2940

tgaagctatt ggtatgggtt ttcctgtgaa agttccctac aggaaaatca caattaaccc   3000

tggctgtgtg gtggttgatg gcatgccccc gggggtgtcc ttcaaagccc ccagctacct   3060

ggaaatcagc tccatgagaa ggatcttaga ctctgccgag tttatcaaat tcacggtcat   3120

tagaccattt ccaggacttg tgattaataa ccagctggtt gatcagagtg agtcagaagg   3180

ccccgtgata caagaatcag ctgaaccaag ccagttggaa gttccagcca cagaagaaat   3240

aaaagagact gatggaagct ctcagatcaa gcaagaacca gaccccacgt ggtagacctc   3300

ttccctccta ggcttaaagt atcagtggtt gagaagagct tttcggacct gttactaccc   3360

caagctgtgt aatatacttg tataacagaa ataccttcta tacaaacctt tttttctact   3420

tttagataga aatgtctact ttttcagcag ttctgtgaat taaagagcag agtgactgtg   3480

ggtctggaat ggctggtgta cttgggaatg tactatcagg attttacagc aatgctggga   3540

aatgacaggg aaaatgacag gaatgaatct caccagattt tttatgtact cagcagagcc   3600

ttgagttacg gtgtttattt tccaatcaag tgaagatatc tcctacttct cctactggaa   3660

catctcagct tctgcagtga agaaaaattc ctgtgatagt tcagttcttt agtttttcta   3720

tttgaaaaaa aaaaatcatt taaatgatcc tttgttcacg gctctcctta atgactgagt   3780

gaacagttcc tatctgtata tttgactaaa ccttttccta agctatctct catggttcct   3840

atgttttttt atcataatta aaagcaaaac catctggatc acctaacagt cagaggtcag   3900

tatctcagcg tgtgaattat agaggaaata cagagagaac ctcttccact tttacttttc   3960

gtccaaataa aatgcatggt gtaccagaag ttgaagatcg ggttgaggat tggggctagc   4020

tcgatgacac taaggcccca acatcgcggg acctgctgtg gcgcggattc ttaggaacgc   4080

tgttctagcc ggccccctct ccaggggtcg ccgtggccgg cattatttcc tagttcttct   4140

tgtaaccctg aggtgccagc gcggggagtg aggaggggtc agggggctaa ggatgcaacc   4200

tctgacgttc tgcgccttcc taggagagtc ttacatgtgt tgagatttca caagcaatgc   4260

gagttgtaaa ataccagctc tacaagaagc taggctctgt gacggcatag ttttcagtag   4320

ctttatcaca atattcacaa tggagaatta tatgacatgg tagcagaaat aggccctttt   4380

atgtgttgct tctattttac ctcaaattgt agatataggg taatcaataa aatccatcca   4440

tgcctttcac acactaagt                                                4459


<210>  4661
<211>  957
<212>  PRT
<213>  Homo sapiens

<400>  4661

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
                565                 570                 575


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
            580                 585                 590


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
        595                 600                 605


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
    610                 615                 620


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
625                 630                 635                 640


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
                645                 650                 655


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
            660                 665                 670


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
        675                 680                 685


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
    690                 695                 700


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
705                 710                 715                 720


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
                725                 730                 735


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
            740                 745                 750


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
        755                 760                 765


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
    770                 775                 780


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
785                 790                 795                 800


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
                805                 810                 815


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
            820                 825                 830


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
        835                 840                 845


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
    850                 855                 860


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
865                 870                 875                 880


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
                885                 890                 895


Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu 
            900                 905                 910


Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu 
        915                 920                 925


Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp 
    930                 935                 940


Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950                 955


<210>  4662
<211>  3926
<212>  DNA
<213>  Homo sapiens

<400>  4662
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   2040

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2100

taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2160

ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2220

ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2280

ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2340

ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2400

atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2460

agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2520

agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2580

tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2640

ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2700

tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2760

ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2820

atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2880

ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2940

tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   3000

ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   3060

tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3120

ttatcaaatt cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg   3180

atcagagtga gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag   3240

ttccagccac agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag   3300

accccacgtg gtagacctct tccctcctag gcaaaaccat ctggatcacc taacagtcag   3360

aggtcagtat ctcagcgtgt gaattataga ggaaatacag agagaacctc ttccactttt   3420

acttttcgtc caaataaaat gcatggtgta ccagaagttg aagatcgggt tgaggattgg   3480

ggctagctcg atgacactaa ggccccaaca tcgcgggacc tgctgtggcg cggattctta   3540

ggaacgctgt tctagccggc cccctctcca ggggtcgccg tggccggcat tatttcctag   3600

ttcttcttgt aaccctgagg tgccagcgcg gggagtgagg aggggtcagg gggctaagga   3660

tgcaacctct gacgttctgc gccttcctag gagagtctta catgtgttga gatttcacaa   3720

gcaatgcgag ttgtaaaata ccagctctac aagaagctag gctctgtgac ggcatagttt   3780

tcagtagctt tatcacaata ttcacaatgg agaattatat gacatggtag cagaaatagg   3840

cccttttatg tgttgcttct attttacctc aaattgtaga tatagggtaa tcaataaaat   3900

ccatccatgc ctttcacaca ctaagt                                        3926


<210>  4663
<211>  909
<212>  PRT
<213>  Homo sapiens

<400>  4663

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
465                 470                 475                 480


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
                485                 490                 495


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
            500                 505                 510


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
        515                 520                 525


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
    530                 535                 540


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
545                 550                 555                 560


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
                565                 570                 575


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
            580                 585                 590


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
        595                 600                 605


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
    610                 615                 620


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
625                 630                 635                 640


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
                645                 650                 655


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
            660                 665                 670


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
        675                 680                 685


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
    690                 695                 700


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
705                 710                 715                 720


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
                725                 730                 735


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
            740                 745                 750


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
        755                 760                 765


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
    770                 775                 780


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
785                 790                 795                 800


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
                805                 810                 815


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
            820                 825                 830


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
        835                 840                 845


Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu 
    850                 855                 860


Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu 
865                 870                 875                 880


Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp 
                885                 890                 895


Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
            900                 905


<210>  4664
<211>  5032
<212>  DNA
<213>  Homo sapiens

<400>  4664
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1860

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1920

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1980

aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc   2040

ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt   2100

tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa   2160

taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg   2220

ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg   2280

ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga gggagagagt   2340

tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct   2400

tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt   2460

tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc   2520

gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa   2580

ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct   2640

ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg   2700

ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga   2760

aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg   2820

gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc   2880

ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc   2940

tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca   3000

ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt gagtcagaag   3060

gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc acagaagaaa   3120

taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg tggtagacct   3180

cttccctcct agggtaaatc agcttctgtg tcagggatgc tgtgtggtgt ccatctgaac   3240

cccctgcata cgcgtagcta atgtgatctc cccactttca cataagatgg tggccctgcc   3300

ttcagggaat gtgggagcca ggtgggagcc ttcccggata tttaagctag aagattctac   3360

agggagattc tccttggatc aatatatgtc tctcagtcaa agatgtaaaa gcacttttgc   3420

cttaaaaaga atgttctgtt tctaaataga gtcaacgttg tcctcctcat tggaattcac   3480

tatgagtcag aatcattaga ctgacttttt tttttccata gtaatagtat tttgcagagt   3540

ctcacagagc tgcagatctt ttgttcatct tgcagagtta acaagtctga tcctgttagt   3600

ccagatttct taaatttggc caagttataa taggagcagt agcttgagac ccgaagtcag   3660

gaaactttga caatggattt ttttttttaa tccagagact tgtactggaa tttgccttac   3720

cctgtcagct catggactta aggtttcatc ccgctttatg agtgcttctg aatccaagtc   3780

attgttacct gaatttgcaa attaagttgt gatattcgtg actgttaaat tcctgtaatt   3840

agattaacct ctttgcttgc ttgtttgttt tctctcctat tttagcttaa agtatcagtg   3900

gttgagaaga gcttttcgga cctgttacta ccccaagctg tgtaatatac ttgtataaca   3960

gaaatacctt ctatacaaac ctttttttct acttttagat agaaatgtct actttttcag   4020

cagttctgtg aattaaagag cagagtgact gtgggtctgg aatggctggt gtacttggga   4080

atgtactatc aggattttac agcaatgctg ggaaatgaca gggaaaatga caggaatgaa   4140

tctcaccaga ttttttatgt actcagcaga gccttgagtt acggtgttta ttttccaatc   4200

aagtgaagat atctcctact tctcctactg gaacatctca gcttctgcag tgaagaaaaa   4260

ttcctgtgat agttcagttc tttagttttt ctatttgaaa aaaaaaaatc atttaaatga   4320

tcctttgttc acggctctcc ttaatgactg agtgaacagt tcctatctgt atatttgact   4380

aaaccttttc ctaagctatc tctcatggtt cctatgtttt tttatcataa ttaaaagcaa   4440

aaccatctgg atcacctaac agtcagaggt cagtatctca gcgtgtgaat tatagaggaa   4500

atacagagag aacctcttcc acttttactt ttcgtccaaa taaaatgcat ggtgtaccag   4560

aagttgaaga tcgggttgag gattggggct agctcgatga cactaaggcc ccaacatcgc   4620

gggacctgct gtggcgcgga ttcttaggaa cgctgttcta gccggccccc tctccagggg   4680

tcgccgtggc cggcattatt tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga   4740

gtgaggaggg gtcagggggc taaggatgca acctctgacg ttctgcgcct tcctaggaga   4800

gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt aaaataccag ctctacaaga   4860

agctaggctc tgtgacggca tagttttcag tagctttatc acaatattca caatggagaa   4920

ttatatgaca tggtagcaga aataggccct tttatgtgtt gcttctattt tacctcaaat   4980

tgtagatata gggtaatcaa taaaatccat ccatgccttt cacacactaa gt           5032


<210>  4665
<211>  863
<212>  PRT
<213>  Homo sapiens

<400>  4665

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg 
            420                 425                 430


Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe 
        435                 440                 445


Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val 
    450                 455                 460


Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly 
465                 470                 475                 480


Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg 
                485                 490                 495


Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu 
            500                 505                 510


Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr 
        515                 520                 525


Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser 
    530                 535                 540


Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn 
545                 550                 555                 560


Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn 
                565                 570                 575


Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn 
            580                 585                 590


Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu 
        595                 600                 605


Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe 
    610                 615                 620


Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro 
625                 630                 635                 640


Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu 
                645                 650                 655


Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys 
            660                 665                 670


Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser 
        675                 680                 685


Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser 
    690                 695                 700


Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp 
705                 710                 715                 720


Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln 
                725                 730                 735


Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly 
            740                 745                 750


Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys 
        755                 760                 765


Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser 
    770                 775                 780


Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe 
785                 790                 795                 800


Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn 
                805                 810                 815


Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser 
            820                 825                 830


Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu 
        835                 840                 845


Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
    850                 855                 860


<210>  4666
<211>  3989
<212>  DNA
<213>  Homo sapiens

<400>  4666
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1860

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1920

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1980

aatcaaaccc ggagttcttg aaaggatcgt ccgcgggagt aataaaatca agttcgttgt   2040

taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta aaataaacac   2100

taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa aggttcctga   2160

aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag ctgttcgaac   2220

cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag agttttcctt   2280

tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc tcttcaatga   2340

gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg cgttatttga   2400

gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat tccgaagacc   2460

atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca aaattaagtt   2520

catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct cctctaagag   2580

ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag gtgttgaaga   2640

ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct cgaaagttga   2700

aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat ttggtgaagc   2760

tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta accctggctg   2820

tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct acctggaaat   2880

cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg tcattagacc   2940

atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag aaggccccgt   3000

gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag aaataaaaga   3060

gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga cctcttccct   3120

cctaggagcc ttgagttacg gtgtttattt tccaatcaag tgaagatatc tcctacttct   3180

cctactggaa catctcagct tctgcagtga agaaaaattc ctgtgatagt tcagttcttt   3240

agtttttcta tttgaaaaaa aaaaatcatt taaatgatcc tttgttcacg gctctcctta   3300

atgactgagt gaacagttcc tatctgtata tttgactaaa ccttttccta agctatctct   3360

catggttcct atgttttttt atcataatta aaagcaaaac catctggatc acctaacagt   3420

cagaggtcag tatctcagcg tgtgaattat agaggaaata cagagagaac ctcttccact   3480

tttacttttc gtccaaataa aatgcatggt gtaccagaag ttgaagatcg ggttgaggat   3540

tggggctagc tcgatgacac taaggcccca acatcgcggg acctgctgtg gcgcggattc   3600

ttaggaacgc tgttctagcc ggccccctct ccaggggtcg ccgtggccgg cattatttcc   3660

tagttcttct tgtaaccctg aggtgccagc gcggggagtg aggaggggtc agggggctaa   3720

ggatgcaacc tctgacgttc tgcgccttcc taggagagtc ttacatgtgt tgagatttca   3780

caagcaatgc gagttgtaaa ataccagctc tacaagaagc taggctctgt gacggcatag   3840

ttttcagtag ctttatcaca atattcacaa tggagaatta tatgacatgg tagcagaaat   3900

aggccctttt atgtgttgct tctattttac ctcaaattgt agatataggg taatcaataa   3960

aatccatcca tgcctttcac acactaagt                                     3989


<210>  4667
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  4667

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg 
            420                 425                 430


Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe 
        435                 440                 445


Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val 
    450                 455                 460


Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile 
465                 470                 475                 480


Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
                485                 490


<210>  4668
<211>  4519
<212>  DNA
<213>  Homo sapiens

<400>  4668
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   2040

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2100

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2160

atcaaacccg gagttcttgt atgtggaagg cttgccagag gggattccct tccgaagccc   2220

tacctggttt ggaattccac gacttgaaag gatcgtccgc gggagtaata aaatcaagtt   2280

cgttgttaaa aaacctgaac tagttatttc ctacttgcct cctgggatgg ctagtaaaat   2340

aaacactaaa gctttgcagt cccccaaaag accacgaagt cctgggagta attcaaaggt   2400

tcctgaaatt gaggtcaccg tggaaggccc taataacaac aatcctcaaa cctcagctgt   2460

tcgaaccccg acccagacta acggttctaa cgttcccttc aagccacgag ggagagagtt   2520

ttcctttgag gcctggaatg ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt   2580

caatgagaaa tgtggggaag ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt   2640

atttgagtct ttcccggaag acttttatgt ggaaggctta cctgagggtg tgccattccg   2700

aagaccatcg acttttggca ttccgaggct ggagaagata ctcagaaaca aagccaaaat   2760

taagttcatc attaaaaagc ccgaaatgtt tgagacggcg attaaggaga gcacctcctc   2820

taagagccct cccagaaaaa taaattcatc acccaatgtt aatactactg catcaggtgt   2880

tgaagacctt aacatcattc aggtgacaat tccagatgat gataatgaaa gactctcgaa   2940

agttgaaaaa gctagacagc taagagaaca agtgaatgac ctctttagtc ggaaatttgg   3000

tgaagctatt ggtatgggtt ttcctgtgaa agttccctac aggaaaatca caattaaccc   3060

tggctgtgtg gtggttgatg gcatgccccc gggggtgtcc ttcaaagccc ccagctacct   3120

ggaaatcagc tccatgagaa ggatcttaga ctctgccgag tttatcaaat tcacggtcat   3180

tagaccattt ccaggacttg tgattaataa ccagctggtt gatcagagtg agtcagaagg   3240

ccccgtgata caagaatcag ctgaaccaag ccagttggaa gttccagcca cagaagaaat   3300

aaaagagact gatggaagct ctcagatcaa gcaagaacca gaccccacgt ggtagacctc   3360

ttccctccta ggcttaaagt atcagtggtt gagaagagct tttcggacct gttactaccc   3420

caagctgtgt aatatacttg tataacagaa ataccttcta tacaaacctt tttttctact   3480

tttagataga aatgtctact ttttcagcag ttctgtgaat taaagagcag agtgactgtg   3540

ggtctggaat ggctggtgta cttgggaatg tactatcagg attttacagc aatgctggga   3600

aatgacaggg aaaatgacag gaatgaatct caccagattt tttatgtact cagcagagcc   3660

ttgagttacg gtgtttattt tccaatcaag tgaagatatc tcctacttct cctactggaa   3720

catctcagct tctgcagtga agaaaaattc ctgtgatagt tcagttcttt agtttttcta   3780

tttgaaaaaa aaaaatcatt taaatgatcc tttgttcacg gctctcctta atgactgagt   3840

gaacagttcc tatctgtata tttgactaaa ccttttccta agctatctct catggttcct   3900

atgttttttt atcataatta aaagcaaaac catctggatc acctaacagt cagaggtcag   3960

tatctcagcg tgtgaattat agaggaaata cagagagaac ctcttccact tttacttttc   4020

gtccaaataa aatgcatggt gtaccagaag ttgaagatcg ggttgaggat tggggctagc   4080

tcgatgacac taaggcccca acatcgcggg acctgctgtg gcgcggattc ttaggaacgc   4140

tgttctagcc ggccccctct ccaggggtcg ccgtggccgg cattatttcc tagttcttct   4200

tgtaaccctg aggtgccagc gcggggagtg aggaggggtc agggggctaa ggatgcaacc   4260

tctgacgttc tgcgccttcc taggagagtc ttacatgtgt tgagatttca caagcaatgc   4320

gagttgtaaa ataccagctc tacaagaagc taggctctgt gacggcatag ttttcagtag   4380

ctttatcaca atattcacaa tggagaatta tatgacatgg tagcagaaat aggccctttt   4440

atgtgttgct tctattttac ctcaaattgt agatataggg taatcaataa aatccatcca   4500

tgcctttcac acactaagt                                                4519


<210>  4669
<211>  977
<212>  PRT
<213>  Homo sapiens

<400>  4669

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
                565                 570                 575


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
            580                 585                 590


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
        595                 600                 605


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
    610                 615                 620


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
625                 630                 635                 640


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
                645                 650                 655


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
            660                 665                 670


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
        675                 680                 685


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
    690                 695                 700


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
705                 710                 715                 720


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
                725                 730                 735


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
            740                 745                 750


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
        755                 760                 765


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
    770                 775                 780


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
785                 790                 795                 800


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
                805                 810                 815


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
            820                 825                 830


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
        835                 840                 845


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
    850                 855                 860


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
865                 870                 875                 880


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
                885                 890                 895


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
            900                 905                 910


Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile 
        915                 920                 925


Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln 
    930                 935                 940


Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile 
945                 950                 955                 960


Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr 
                965                 970                 975


Trp 



<210>  4670
<211>  5272
<212>  DNA
<213>  Homo sapiens

<400>  4670
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   2040

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2100

gaaatttgct tagatttgtt gacagcggtt tcctggagtg ctgtcttgag aacgattctg   2160

aggaggctca gcaagaaaga gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa   2220

ctcaagctct tggactcacc gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc   2280

cggagttctt gtatgtggaa ggcttgccag aggggattcc cttccgaagc cctacctggt   2340

ttggaattcc acgacttgaa aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta   2400

aaaaacctga actagttatt tcctacttgc ctcctgggat ggctagtaaa ataaacacta   2460

aagctttgca gtcccccaaa agaccacgaa gtcctgggag taattcaaag gttcctgaaa   2520

ttgaggtcac cgtggaaggc cctaataaca acaatcctca aacctcagct gttcgaaccc   2580

cgacccagac taacggttct aacgttccct tcaagccacg agggagagag ttttcctttg   2640

aggcctggaa tgccaaaatc acggacctaa aacagaaagt tgaaaatctc ttcaatgaga   2700

aatgtgggga agctcttggc cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt   2760

ctttcccgga agacttttat gtggaaggct tacctgaggg tgtgccattc cgaagaccat   2820

cgacttttgg cattccgagg ctggagaaga tactcagaaa caaagccaaa attaagttca   2880

tcattaaaaa gcccgaaatg tttgagacgg cgattaagga gagcacctcc tctaagagcc   2940

ctcccagaaa aataaattca tcacccaatg ttaatactac tgcatcaggt gttgaagacc   3000

ttaacatcat tcaggtgaca attccagatg atgataatga aagactctcg aaagttgaaa   3060

aagctagaca gctaagagaa caagtgaatg acctctttag tcggaaattt ggtgaagcta   3120

ttggtatggg ttttcctgtg aaagttccct acaggaaaat cacaattaac cctggctgtg   3180

tggtggttga tggcatgccc ccgggggtgt ccttcaaagc ccccagctac ctggaaatca   3240

gctccatgag aaggatctta gactctgccg agtttatcaa attcacggtc attagaccat   3300

ttccaggact tgtgattaat aaccagctgg ttgatcagag tgagtcagaa ggccccgtga   3360

tacaagaatc agctgaacca agccagttgg aagttccagc cacagaaggt aaaaggacct   3420

cttccctcct agggtaaatc agcttctgtg tcagggatgc tgtgtggtgt ccatctgaac   3480

cccctgcata cgcgtagcta atgtgatctc cccactttca cataagatgg tggccctgcc   3540

ttcagggaat gtgggagcca ggtgggagcc ttcccggata tttaagctag aagattctac   3600

agggagattc tccttggatc aatatatgtc tctcagtcaa agatgtaaaa gcacttttgc   3660

cttaaaaaga atgttctgtt tctaaataga gtcaacgttg tcctcctcat tggaattcac   3720

tatgagtcag aatcattaga ctgacttttt tttttccata gtaatagtat tttgcagagt   3780

ctcacagagc tgcagatctt ttgttcatct tgcagagtta acaagtctga tcctgttagt   3840

ccagatttct taaatttggc caagttataa taggagcagt agcttgagac ccgaagtcag   3900

gaaactttga caatggattt ttttttttaa tccagagact tgtactggaa tttgccttac   3960

cctgtcagct catggactta aggtttcatc ccgctttatg agtgcttctg aatccaagtc   4020

attgttacct gaatttgcaa attaagttgt gatattcgtg actgttaaat tcctgtaatt   4080

agattaacct ctttgcttgc ttgtttgttt tctctcctat tttagcttaa agtatcagtg   4140

gttgagaaga gcttttcgga cctgttacta ccccaagctg tgtaatatac ttgtataaca   4200

gaaatacctt ctatacaaac ctttttttct acttttagat agaaatgtct actttttcag   4260

cagttctgtg aattaaagag cagagtgact gtgggtctgg aatggctggt gtacttggga   4320

atgtactatc aggattttac agcaatgctg ggaaatgaca gggaaaatga caggaatgaa   4380

tctcaccaga ttttttatgt actcagcaga gccttgagtt acggtgttta ttttccaatc   4440

aagtgaagat atctcctact tctcctactg gaacatctca gcttctgcag tgaagaaaaa   4500

ttcctgtgat agttcagttc tttagttttt ctatttgaaa aaaaaaaatc atttaaatga   4560

tcctttgttc acggctctcc ttaatgactg agtgaacagt tcctatctgt atatttgact   4620

aaaccttttc ctaagctatc tctcatggtt cctatgtttt tttatcataa ttaaaagcaa   4680

aaccatctgg atcacctaac agtcagaggt cagtatctca gcgtgtgaat tatagaggaa   4740

atacagagag aacctcttcc acttttactt ttcgtccaaa taaaatgcat ggtgtaccag   4800

aagttgaaga tcgggttgag gattggggct agctcgatga cactaaggcc ccaacatcgc   4860

gggacctgct gtggcgcgga ttcttaggaa cgctgttcta gccggccccc tctccagggg   4920

tcgccgtggc cggcattatt tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga   4980

gtgaggaggg gtcagggggc taaggatgca acctctgacg ttctgcgcct tcctaggaga   5040

gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt aaaataccag ctctacaaga   5100

agctaggctc tgtgacggca tagttttcag tagctttatc acaatattca caatggagaa   5160

ttatatgaca tggtagcaga aataggccct tttatgtgtt gcttctattt tacctcaaat   5220

tgtagatata gggtaatcaa taaaatccat ccatgccttt cacacactaa gt           5272


<210>  4671
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  4671

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala 



<210>  4672
<211>  4406
<212>  DNA
<213>  Homo sapiens

<400>  4672
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   2040

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   2100

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2160

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2220

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2280

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2340

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2400

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2460

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2520

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2580

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2640

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2700

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2760

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2820

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2880

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2940

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   3000

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   3060

cggtcattag accatttcca ggacttgtga ttaataacca gctggttgat cagagtgagt   3120

cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt ccagccacag   3180

aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac cccacgtggt   3240

agacctcttc cctcctaggc ttaaagtatc agtggttgag aagagctttt cggacctgtt   3300

actaccccaa gctgtgtaat atacttgtat aacagaaata ccttctatac aaaccttttt   3360

ttctactttt agatagaaat gtctactttt tcagcagttc tgtgaattaa agagcagagt   3420

gactgtgggt ctggaatggc tggtgtactt gggaatgtac tatcaggatt ttacagcaat   3480

gctgggaaat gacagggaaa atgacaggaa tgaatctcac cagatttttt atgtactcag   3540

cagagccttg agttacggtg tttattttcc aatcaagtga agatatctcc tacttctcct   3600

actggaacat ctcagcttct gcagtgaaga aaaattcctg tgatagttca gttctttagt   3660

ttttctattt gaaaaaaaaa aatcatttaa atgatccttt gttcacggct ctccttaatg   3720

actgagtgaa cagttcctat ctgtatattt gactaaacct tttcctaagc tatctctcat   3780

ggttcctatg tttttttatc ataattaaaa gcaaaaccat ctggatcacc taacagtcag   3840

aggtcagtat ctcagcgtgt gaattataga ggaaatacag agagaacctc ttccactttt   3900

acttttcgtc caaataaaat gcatggtgta ccagaagttg aagatcgggt tgaggattgg   3960

ggctagctcg atgacactaa ggccccaaca tcgcgggacc tgctgtggcg cggattctta   4020

ggaacgctgt tctagccggc cccctctcca ggggtcgccg tggccggcat tatttcctag   4080

ttcttcttgt aaccctgagg tgccagcgcg gggagtgagg aggggtcagg gggctaagga   4140

tgcaacctct gacgttctgc gccttcctag gagagtctta catgtgttga gatttcacaa   4200

gcaatgcgag ttgtaaaata ccagctctac aagaagctag gctctgtgac ggcatagttt   4260

tcagtagctt tatcacaata ttcacaatgg agaattatat gacatggtag cagaaatagg   4320

cccttttatg tgttgcttct attttacctc aaattgtaga tatagggtaa tcaataaaat   4380

ccatccatgc ctttcacaca ctaagt                                        4406


<210>  4673
<211>  885
<212>  PRT
<213>  Homo sapiens

<400>  4673

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
465                 470                 475                 480


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
                485                 490                 495


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
            500                 505                 510


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
        515                 520                 525


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
    530                 535                 540


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
545                 550                 555                 560


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
                565                 570                 575


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
            580                 585                 590


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
        595                 600                 605


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
    610                 615                 620


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
625                 630                 635                 640


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
                645                 650                 655


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
            660                 665                 670


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
        675                 680                 685


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
    690                 695                 700


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
705                 710                 715                 720


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
                725                 730                 735


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
            740                 745                 750


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
        755                 760                 765


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
    770                 775                 780


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
785                 790                 795                 800


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
                805                 810                 815


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro 
            820                 825                 830


Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly 
        835                 840                 845


Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala 
    850                 855                 860


Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu 
865                 870                 875                 880


Pro Asp Pro Thr Trp 
                885


<210>  4674
<211>  5005
<212>  DNA
<213>  Homo sapiens

<400>  4674
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gtcaaagaag attggaatgt cagaattacc aagctacgga   1920

agcaagtgga agagattttt aatttgaaat ttgctcaagc tcttggactc accgaggcag   1980

taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgtatgtg gaaggcttgc   2040

cagaggggat tcccttccga agccctacct ggtttggaat tccacgactt gaaaggatcg   2100

tccgcgggag taataaaatc aagttcgttg ttaaaaaacc tgaactagtt atttcctact   2160

tgcctcctgg gatggctagt aaaataaaca ctaaagcttt gcagtccccc aaaagaccac   2220

gaagtcctgg gagtaattca aaggttcctg aaattgaggt caccgtggaa ggccctaata   2280

acaacaatcc tcaaacctca gctgttcgaa ccccgaccca gactaacggt tctaacgttc   2340

ccttcaagcc acgagggaga gagttttcct ttgaggcctg gaatgccaaa atcacggacc   2400

taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg ggaagctctt ggccttaaac   2460

aagctgtgaa ggtgccgttc gcgttatttg agtctttccc ggaagacttt tatgtggaag   2520

gcttacctga gggtgtgcca ttccgaagac catcgacttt tggcattccg aggctggaga   2580

agatactcag aaacaaagcc aaaattaagt tcatcattaa aaagcccgaa atgtttgaga   2640

cggcgattaa ggagagcacc tcctctaaga gccctcccag aaaaataaat tcatcaccca   2700

atgttaatac tactgcatca ggtgttgaag accttaacat cattcaggtg acaattccag   2760

atgatgataa tgaaagactc tcgaaagttg aaaaagctag acagctaaga gaacaagtga   2820

atgacctctt tagtcggaaa tttggtgaag ctattggtat gggttttcct gtgaaagttc   2880

cctacaggaa aatcacaatt aaccctggct gtgtggtggt tgatggcatg cccccggggg   2940

tgtccttcaa agcccccagc tacctggaaa tcagctccat gagaaggatc ttagactctg   3000

ccgagtttat caaattcacg gtcattagac catttccagg acttgtgatt aataaccagc   3060

tggttgatca gagtgagtca gaaggccccg tgatacaaga atcagctgaa ccaagccagt   3120

tggaagttcc agccacagaa ggtaaaagga cctcttccct cctagggtaa atcagcttct   3180

gtgtcaggga tgctgtgtgg tgtccatctg aaccccctgc atacgcgtag ctaatgtgat   3240

ctccccactt tcacataaga tggtggccct gccttcaggg aatgtgggag ccaggtggga   3300

gccttcccgg atatttaagc tagaagattc tacagggaga ttctccttgg atcaatatat   3360

gtctctcagt caaagatgta aaagcacttt tgccttaaaa agaatgttct gtttctaaat   3420

agagtcaacg ttgtcctcct cattggaatt cactatgagt cagaatcatt agactgactt   3480

ttttttttcc atagtaatag tattttgcag agtctcacag agctgcagat cttttgttca   3540

tcttgcagag ttaacaagtc tgatcctgtt agtccagatt tcttaaattt ggccaagtta   3600

taataggagc agtagcttga gacccgaagt caggaaactt tgacaatgga tttttttttt   3660

taatccagag acttgtactg gaatttgcct taccctgtca gctcatggac ttaaggtttc   3720

atcccgcttt atgagtgctt ctgaatccaa gtcattgtta cctgaatttg caaattaagt   3780

tgtgatattc gtgactgtta aattcctgta attagattaa cctctttgct tgcttgtttg   3840

ttttctctcc tattttagct taaagtatca gtggttgaga agagcttttc ggacctgtta   3900

ctaccccaag ctgtgtaata tacttgtata acagaaatac cttctataca aacctttttt   3960

tctactttta gatagaaatg tctacttttt cagcagttct gtgaattaaa gagcagagtg   4020

actgtgggtc tggaatggct ggtgtacttg ggaatgtact atcaggattt tacagcaatg   4080

ctgggaaatg acagggaaaa tgacaggaat gaatctcacc agatttttta tgtactcagc   4140

agagccttga gttacggtgt ttattttcca atcaagtgaa gatatctcct acttctccta   4200

ctggaacatc tcagcttctg cagtgaagaa aaattcctgt gatagttcag ttctttagtt   4260

tttctatttg aaaaaaaaaa atcatttaaa tgatcctttg ttcacggctc tccttaatga   4320

ctgagtgaac agttcctatc tgtatatttg actaaacctt ttcctaagct atctctcatg   4380

gttcctatgt ttttttatca taattaaaag caaaaccatc tggatcacct aacagtcaga   4440

ggtcagtatc tcagcgtgtg aattatagag gaaatacaga gagaacctct tccactttta   4500

cttttcgtcc aaataaaatg catggtgtac cagaagttga agatcgggtt gaggattggg   4560

gctagctcga tgacactaag gccccaacat cgcgggacct gctgtggcgc ggattcttag   4620

gaacgctgtt ctagccggcc ccctctccag gggtcgccgt ggccggcatt atttcctagt   4680

tcttcttgta accctgaggt gccagcgcgg ggagtgagga ggggtcaggg ggctaaggat   4740

gcaacctctg acgttctgcg ccttcctagg agagtcttac atgtgttgag atttcacaag   4800

caatgcgagt tgtaaaatac cagctctaca agaagctagg ctctgtgacg gcatagtttt   4860

cagtagcttt atcacaatat tcacaatgga gaattatatg acatggtagc agaaataggc   4920

ccttttatgt gttgcttcta ttttacctca aattgtagat atagggtaat caataaaatc   4980

catccatgcc tttcacacac taagt                                         5005


<210>  4675
<211>  922
<212>  PRT
<213>  Homo sapiens

<400>  4675

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
                485                 490                 495


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
            500                 505                 510


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
        515                 520                 525


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu 
    530                 535                 540


Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile 
545                 550                 555                 560


Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val 
                565                 570                 575


Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala 
            580                 585                 590


Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser 
        595                 600                 605


Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly 
    610                 615                 620


Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln 
625                 630                 635                 640


Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser 
                645                 650                 655


Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu 
            660                 665                 670


Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala 
        675                 680                 685


Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr 
    690                 695                 700


Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe 
705                 710                 715                 720


Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys 
                725                 730                 735


Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser 
            740                 745                 750


Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val 
        755                 760                 765


Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr 
    770                 775                 780


Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg 
785                 790                 795                 800


Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu 
                805                 810                 815


Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr 
            820                 825                 830


Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser 
        835                 840                 845


Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu 
    850                 855                 860


Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly 
865                 870                 875                 880


Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro 
                885                 890                 895


Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr 
            900                 905                 910


Glu Gly Lys Arg Thr Ser Ser Leu Leu Gly 
        915                 920


<210>  4676
<211>  5107
<212>  DNA
<213>  Homo sapiens

<400>  4676
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1980

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   2040

catatcctgt gtttgaatca aacccggagt tcttgtatgt ggaaggcttg ccagagggga   2100

ttcccttccg aagccctacc tggtttggaa ttccacgact tgaaaggatc gtccgcggga   2160

gtaataaaat caagttcgtt gttaaaaaac ctgaactagt tatttcctac ttgcctcctg   2220

ggatggctag taaaataaac actaaagctt tgcagtcccc caaaagacca cgaagtcctg   2280

ggagtaattc aaaggttcct gaaattgagg tcaccgtgga aggccctaat aacaacaatc   2340

ctcaaacctc agctgttcga accccgaccc agactaacgg ttctaacgtt cccttcaagc   2400

cacgagggag agagttttcc tttgaggcct ggaatgccaa aatcacggac ctaaaacaga   2460

aagttgaaaa tctcttcaat gagaaatgtg gggaagctct tggccttaaa caagctgtga   2520

aggtgccgtt cgcgttattt gagtctttcc cggaagactt ttatgtggaa ggcttacctg   2580

agggtgtgcc attccgaaga ccatcgactt ttggcattcc gaggctggag aagatactca   2640

gaaacaaagc caaaattaag ttcatcatta aaaagcccga aatgtttgag acggcgatta   2700

aggagagcac ctcctctaag agccctccca gaaaaataaa ttcatcaccc aatgttaata   2760

ctactgcatc aggtgttgaa gaccttaaca tcattcaggt gacaattcca gatgatgata   2820

atgaaagact ctcgaaagtt gaaaaagcta gacagctaag agaacaagtg aatgacctct   2880

ttagtcggaa atttggtgaa gctattggta tgggttttcc tgtgaaagtt ccctacagga   2940

aaatcacaat taaccctggc tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca   3000

aagcccccag ctacctggaa atcagctcca tgagaaggat cttagactct gccgagttta   3060

tcaaattcac ggtcattaga ccatttccag gacttgtgat taataaccag ctggttgatc   3120

agagtgagtc agaaggcccc gtgatacaag aatcagctga accaagccag ttggaagttc   3180

cagccacaga agaaataaaa gagactgatg gaagctctca gatcaagcaa gaaccagacc   3240

ccacgtggta gacctcttcc ctcctagggt aaatcagctt ctgtgtcagg gatgctgtgt   3300

ggtgtccatc tgaaccccct gcatacgcgt agctaatgtg atctccccac tttcacataa   3360

gatggtggcc ctgccttcag ggaatgtggg agccaggtgg gagccttccc ggatatttaa   3420

gctagaagat tctacaggga gattctcctt ggatcaatat atgtctctca gtcaaagatg   3480

taaaagcact tttgccttaa aaagaatgtt ctgtttctaa atagagtcaa cgttgtcctc   3540

ctcattggaa ttcactatga gtcagaatca ttagactgac tttttttttt ccatagtaat   3600

agtattttgc agagtctcac agagctgcag atcttttgtt catcttgcag agttaacaag   3660

tctgatcctg ttagtccaga tttcttaaat ttggccaagt tataatagga gcagtagctt   3720

gagacccgaa gtcaggaaac tttgacaatg gatttttttt tttaatccag agacttgtac   3780

tggaatttgc cttaccctgt cagctcatgg acttaaggtt tcatcccgct ttatgagtgc   3840

ttctgaatcc aagtcattgt tacctgaatt tgcaaattaa gttgtgatat tcgtgactgt   3900

taaattcctg taattagatt aacctctttg cttgcttgtt tgttttctct cctattttag   3960

cttaaagtat cagtggttga gaagagcttt tcggacctgt tactacccca agctgtgtaa   4020

tatacttgta taacagaaat accttctata caaacctttt tttctacttt tagatagaaa   4080

tgtctacttt ttcagcagtt ctgtgaatta aagagcagag tgactgtggg tctggaatgg   4140

ctggtgtact tgggaatgta ctatcaggat tttacagcaa tgctgggaaa tgacagggaa   4200

aatgacagga atgaatctca ccagattttt tatgtactca gcagagcctt gagttacggt   4260

gtttattttc caatcaagtg aagatatctc ctacttctcc tactggaaca tctcagcttc   4320

tgcagtgaag aaaaattcct gtgatagttc agttctttag tttttctatt tgaaaaaaaa   4380

aaatcattta aatgatcctt tgttcacggc tctccttaat gactgagtga acagttccta   4440

tctgtatatt tgactaaacc ttttcctaag ctatctctca tggttcctat gtttttttat   4500

cataattaaa agcaaaacca tctggatcac ctaacagtca gaggtcagta tctcagcgtg   4560

tgaattatag aggaaataca gagagaacct cttccacttt tacttttcgt ccaaataaaa   4620

tgcatggtgt accagaagtt gaagatcggg ttgaggattg gggctagctc gatgacacta   4680

aggccccaac atcgcgggac ctgctgtggc gcggattctt aggaacgctg ttctagccgg   4740

ccccctctcc aggggtcgcc gtggccggca ttatttccta gttcttcttg taaccctgag   4800

gtgccagcgc ggggagtgag gaggggtcag ggggctaagg atgcaacctc tgacgttctg   4860

cgccttccta ggagagtctt acatgtgttg agatttcaca agcaatgcga gttgtaaaat   4920

accagctcta caagaagcta ggctctgtga cggcatagtt ttcagtagct ttatcacaat   4980

attcacaatg gagaattata tgacatggta gcagaaatag gcccttttat gtgttgcttc   5040

tattttacct caaattgtag atatagggta atcaataaaa tccatccatg cctttcacac   5100

actaagt                                                             5107


<210>  4677
<211>  888
<212>  PRT
<213>  Homo sapiens

<400>  4677

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
    450                 455                 460


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
465                 470                 475                 480


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
                485                 490                 495


Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr 
            500                 505                 510


Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys 
        515                 520                 525


Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro 
    530                 535                 540


Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys 
545                 550                 555                 560


Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val 
                565                 570                 575


Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg 
            580                 585                 590


Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly 
        595                 600                 605


Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys 
    610                 615                 620


Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly 
625                 630                 635                 640


Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro 
                645                 650                 655


Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg 
            660                 665                 670


Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys 
        675                 680                 685


Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala 
    690                 695                 700


Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser 
705                 710                 715                 720


Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile 
                725                 730                 735


Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val 
            740                 745                 750


Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg 
        755                 760                 765


Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr 
    770                 775                 780


Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro 
785                 790                 795                 800


Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met 
                805                 810                 815


Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
            820                 825                 830


Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu 
        835                 840                 845


Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu 
    850                 855                 860


Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile 
865                 870                 875                 880


Lys Gln Glu Pro Asp Pro Thr Trp 
                885


<210>  4678
<211>  3892
<212>  DNA
<213>  Homo sapiens

<400>  4678
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gtcaaagaag attggaatgt   1980

cagaattacc aagctacgga agcaagtgga agagattttt aatttgaaat ttgctcaagc   2040

tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt   2100

cttgtatgtg gaaggcttgc cagaggggat tcccttccga agccctacct ggtttggaat   2160

tccacgactt gaaaggatcg tccgcgggag taataaaatc aagttcgttg ttaaaaaacc   2220

tgaactagtt atttcctact tgcctcctgg gatggctagt aaaataaaca ctaaagcttt   2280

gcagtccccc aaaagaccac gaagtcctgg gagtaattca aaggttcctg aaattgaggt   2340

caccgtggaa ggccctaata acaacaatcc tcaaacctca gctgttcgaa ccccgaccca   2400

gactaacggt tctaacgttc ccttcaagcc acgagggaga gagttttcct ttgaggcctg   2460

gaatgccaaa atcacggacc taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg   2520

ggaagctctt ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg agtctttccc   2580

ggaagacttt tatgtggaag gcttacctga gggtgtgcca ttccgaagac catcgacttt   2640

tggcattccg aggctggaga agatactcag aaacaaagcc aaaattaagt tcatcattaa   2700

aaagcccgaa atgtttgaga cggcgattaa ggagagcacc tcctctaaga gccctcccag   2760

aaaaataaat tcatcaccca atgttaatac tactgcatca ggtgttgaag accttaacat   2820

cattcaggtg acaattccag atgatgataa tgaaagactc tcgaaagttg aaaaagctag   2880

acagctaaga gaacaagtga atgacctctt tagtcggaaa tttggtgaag ctattggtat   2940

gggttttcct gtgaaagttc cctacaggaa aatcacaatt aaccctggct gtgtggtggt   3000

tgatggcatg cccccggggg tgtccttcaa agcccccagc tacctggaaa tcagctccat   3060

gagaaggatc ttagactctg ccgagtttat caaattcacg gtcattagac catttccagg   3120

acttgtgatt aataaccagc tggttgatca gagtgagtca gaaggccccg tgatacaaga   3180

atcagctgaa ccaagccagt tggaagttcc agccacagaa gaaataaaag agactgatgg   3240

aagctctcag atcaagcaag aaccagaccc cacgtggtag acctcttccc tcctaggcaa   3300

aaccatctgg atcacctaac agtcagaggt cagtatctca gcgtgtgaat tatagaggaa   3360

atacagagag aacctcttcc acttttactt ttcgtccaaa taaaatgcat ggtgtaccag   3420

aagttgaaga tcgggttgag gattggggct agctcgatga cactaaggcc ccaacatcgc   3480

gggacctgct gtggcgcgga ttcttaggaa cgctgttcta gccggccccc tctccagggg   3540

tcgccgtggc cggcattatt tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga   3600

gtgaggaggg gtcagggggc taaggatgca acctctgacg ttctgcgcct tcctaggaga   3660

gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt aaaataccag ctctacaaga   3720

agctaggctc tgtgacggca tagttttcag tagctttatc acaatattca caatggagaa   3780

ttatatgaca tggtagcaga aataggccct tttatgtgtt gcttctattt tacctcaaat   3840

tgtagatata gggtaatcaa taaaatccat ccatgccttt cacacactaa gt           3892


<210>  4679
<211>  952
<212>  PRT
<213>  Homo sapiens

<400>  4679

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr 
                565                 570                 575


Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys 
            580                 585                 590


Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro 
        595                 600                 605


Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys 
    610                 615                 620


Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val 
625                 630                 635                 640


Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg 
                645                 650                 655


Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly 
            660                 665                 670


Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys 
        675                 680                 685


Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly 
    690                 695                 700


Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro 
705                 710                 715                 720


Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg 
                725                 730                 735


Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys 
            740                 745                 750


Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala 
        755                 760                 765


Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser 
    770                 775                 780


Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile 
785                 790                 795                 800


Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val 
                805                 810                 815


Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg 
            820                 825                 830


Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr 
        835                 840                 845


Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro 
    850                 855                 860


Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met 
865                 870                 875                 880


Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
                885                 890                 895


Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu 
            900                 905                 910


Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu 
        915                 920                 925


Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile 
    930                 935                 940


Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  4680
<211>  8067
<212>  DNA
<213>  Homo sapiens

<400>  4680
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   2040

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gcttagattt   2100

gttgacagcg gtttcctgga gtgctgtctt gagaacgatt ctgaggaggc tcagcaagaa   2160

agagtgtttc agttgattgg gtgtgtctgt catggagaag gaactcaagc tcttggactc   2220

accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgtatgtg   2280

gaaggcttgc cagaggggat tcccttccga agccctacct ggtttggaat tccacgactt   2340

gaaaggatcg tccgcgggag taataaaatc aagttcgttg ttaaaaaacc tgaactagtt   2400

atttcctact tgcctcctgg gatggctagt aaaataaaca ctaaagcttt gcagtccccc   2460

aaaagaccac gaagtcctgg gagtaattca aaggttcctg aaattgaggt caccgtggaa   2520

ggccctaata acaacaatcc tcaaacctca gctgttcgaa ccccgaccca gactaacggt   2580

tctaacgttc ccttcaagcc acgagggaga gagttttcct ttgaggcctg gaatgccaaa   2640

atcacggacc taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg ggaagctctt   2700

ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg agtctttccc ggaagacttt   2760

tatgtggaag gcttacctga gggtgtgcca ttccgaagac catcgacttt tggcattccg   2820

aggctggaga agatactcag aaacaaagcc aaaattaagt tcatcattaa aaagcccgaa   2880

atgtttgaga cggcgattaa ggagagcacc tcctctaaga gccctcccag aaaaataaat   2940

tcatcaccca atgttaatac tactgcatca ggtgttgaag accttaacat cattcaggtg   3000

acaattccag atgatgataa tgaaagactc tcgaaagttg aaaaagctag acagctaaga   3060

gaacaagtga atgacctctt tagtcggaaa tttggtgaag ctattggtat gggttttcct   3120

gtgaaagttc cctacaggaa aatcacaatt aaccctggct gtgtggtggt tgatggcatg   3180

cccccggggg tgtccttcaa agcccccagc tacctggaaa tcagctccat gagaaggatc   3240

ttagactctg ccgagtttat caaattcacg gtcattaggt aagtgagagt ttcctgctta   3300

gtcacaggag cgaatctgga gctcatgagg ctgactcttc taaaatgcag ccacaggtag   3360

tcatcgaatc cggcttccta tgctgtgcaa tcaacaaatc aaaataactt gtgtcatcat   3420

tagaatgtca gatgtgcttc tacgaactaa gctgactctt ttaattcttt ggcaaagggt   3480

tggcaaacta ggactgtttg ccaaattcag gctgcctcct atttttagag tcttcctgaa   3540

acacagctac acccgtatta tccatggctg ctttcctgtc acagtgagta agtagctggg   3600

actgagaagg catggcctcc aaagtctaaa atatttactc tctagcactt tgtagaaaaa   3660

ccttagctag gcacagtggc taacgcctgt aatcccagca ttttgggagg ccaaggcagg   3720

cagatcacct gaggtcagga gttccagacc agcctggcca acatggtgaa atcccatctc   3780

tacaaaaata aaacagttag ctgggcatga tggcgggtgc ctgtaatccc agctactcgg   3840

gaggctgagg caggatagtc gcttgaaccc aggaggtgga ggttgcaatg agccaagatc   3900

atgccactgc actccagcct ggacgacaga gtgagactcc atcacaagaa aaaaagaact   3960

ttgtcaacct ctgtcttagg gcgccttgtc acaggcttcg ggtcagacgg attcaacctt   4020

gcatcagcca tttgttagcc aggtcactct gttctttgtc tgtaaatgag attgatcgtt   4080

gttcccactg agagtgtcag ctccttcccg tagagcaggc atgatgattg tactcacctc   4140

tgacaccatt gtgagtgcca cattccttcc cacgtccttg tcactgtaag agatgcccac   4200

ctgagcacca accccaggtt atcttcccct ttgtcttcca gccccccaga aacagctacg   4260

actcaaccta cccaatcatt tcatcatcag attgccactg tctctagttc aggtctcttg   4320

ggactggcac tcagaaatct cataataaat cctcttgagg cttctcatac actcgtcttc   4380

ttccaatctt ctttccctca aaatctcata ttttggttcc acttcaccca ccgtcattct   4440

ccatatcact cccaggagtt aggcaaaaag ccccttccgt tcttccgtat gttaaactta   4500

gaatcactct gttccctgct ctgcgtttct attttttgtt tttcctccat ttactagtag   4560

cttaacactt tctaacagtg ttcttattat tgatacgtat ctatctcttc cataagctta   4620

taaggtcacg gataatactt ctcattgtag tacgtaaatg acgtgggcta gatatgagtt   4680

gaataaacag ttatacctgt aaattcttac agagtgaaaa taaattgtta tactttacaa   4740

tttgtttctc tctttagacc atttccagga cttgtgatta ataaccgtga gtattttgtg   4800

aagtgttttg tttttgtttt ttcctggggt ctgacgtgtg tgcgtgtgag tgtgtataca   4860

tgcttaacgt atatcacgtt acttcaccta tgtcagtaac caggccaaat acttgtttta   4920

gccctcagta aaaacaccag gcacttccta gttgtaaaat tattcaagct tcttaacttc   4980

ctatcctcga tgcacttaat cataaaatgg taataatagc accgattttg ggggagtcgt   5040

tccagtagat ggaaagcatc tggaacaggt gtcagcaagc tcctgccgac gtgtatgcat   5100

aaagttttat tgaaaccacc atcgtgtcca tttgtttatg gcagaactga gagatggcag   5160

cagcaagtgt gtgcctgcaa aacctaaaat atttactaat tggctctgca agaaaagagt   5220

ttgcatcccc ctaacctaga acagtgtcta gcctctagta tgtgtttagc ctacagtatg   5280

tgctcagcga atacaatcta tatttattac tgcttttatg actgttataa ttactgtgct   5340

tggatttcgt tacaaagtaa gtcacaatgt gcctgcttct gttagtattt cagcacagtg   5400

cctggcacac atggggctct caaatattgc tgagcgagtg aacaaatgtc ctttcaattc   5460

cttaacgttg atgtcatttt caatagtatt ttgagccaaa cttaattttg cgagtgtgtt   5520

ttgttttctt aactttatta ttaaaaatgt ataaaagtga ggccaggcgt ggtggctcac   5580

gcctgtaatc ccagcagttt gggaggctga ggcaggcgga tcagttgagg ttgggagttg   5640

gagaccagcc cgtccaacat ggtgaaagcc tgtctctact aaaaatacaa aaatcagctg   5700

ggtgtggtgg cgcgtgcctg taatcccagc tactcaggag gctgaggcag gagagttgct   5760

tgaatcctag aggtggaggt tgcagtgagc tgagatcgtg ccattgcact ccagcctggg   5820

caacaagagc aaaactctgt cccaataaat aaataaataa aatgttctct tttgttcctg   5880

ttcttgtgcg gtagtgtggt atagagtttt atggtaatta ctgtgaatta gtgattctga   5940

gggacatatc agaactctga ggtttgtttc cttctcatct tgagggaaac agcaaatgta   6000

tgttaaaatg cttttccaag ggaacaacac atccttacat tatttaaacc aatctgcttc   6060

attttcagag ctggttgatc agagtgagtc agaaggcccc gtgatacaag aatcagctga   6120

accaagccag ttggaagttc cagccacaga agaaataaaa gagactgatg gaagctctca   6180

gatcaagcaa gaaccagacc ccacgtggta gacctcttcc ctcctagggt aaatcagctt   6240

ctgtgtcagg gatgctgtgt ggtgtccatc tgaaccccct gcatacgcgt agctaatgtg   6300

atctccccac tttcacataa gatggtggcc ctgccttcag ggaatgtggg agccaggtgg   6360

gagccttccc ggatatttaa gctagaagat tctacaggga gattctcctt ggatcaatat   6420

atgtctctca gtcaaagatg taaaagcact tttgccttaa aaagaatgtt ctgtttctaa   6480

atagagtcaa cgttgtcctc ctcattggaa ttcactatga gtcagaatca ttagactgac   6540

tttttttttt ccatagtaat agtattttgc agagtctcac agagctgcag atcttttgtt   6600

catcttgcag agttaacaag tctgatcctg ttagtccaga tttcttaaat ttggccaagt   6660

tataatagga gcagtagctt gagacccgaa gtcaggaaac tttgacaatg gatttttttt   6720

tttaatccag agacttgtac tggaatttgc cttaccctgt cagctcatgg acttaaggtt   6780

tcatcccgct ttatgagtgc ttctgaatcc aagtcattgt tacctgaatt tgcaaattaa   6840

gttgtgatat tcgtgactgt taaattcctg taattagatt aacctctttg cttgcttgtt   6900

tgttttctct cctattttag cttaaagtat cagtggttga gaagagcttt tcggacctgt   6960

tactacccca agctgtgtaa tatacttgta taacagaaat accttctata caaacctttt   7020

tttctacttt tagatagaaa tgtctacttt ttcagcagtt ctgtgaatta aagagcagag   7080

tgactgtggg tctggaatgg ctggtgtact tgggaatgta ctatcaggat tttacagcaa   7140

tgctgggaaa tgacagggaa aatgacagga atgaatctca ccagattttt tatgtactca   7200

gcagagcctt gagttacggt gtttattttc caatcaagtg aagatatctc ctacttctcc   7260

tactggaaca tctcagcttc tgcagtgaag aaaaattcct gtgatagttc agttctttag   7320

tttttctatt tgaaaaaaaa aaatcattta aatgatcctt tgttcacggc tctccttaat   7380

gactgagtga acagttccta tctgtatatt tgactaaacc ttttcctaag ctatctctca   7440

tggttcctat gtttttttat cataattaaa agcaaaacca tctggatcac ctaacagtca   7500

gaggtcagta tctcagcgtg tgaattatag aggaaataca gagagaacct cttccacttt   7560

tacttttcgt ccaaataaaa tgcatggtgt accagaagtt gaagatcggg ttgaggattg   7620

gggctagctc gatgacacta aggccccaac atcgcgggac ctgctgtggc gcggattctt   7680

aggaacgctg ttctagccgg ccccctctcc aggggtcgcc gtggccggca ttatttccta   7740

gttcttcttg taaccctgag gtgccagcgc ggggagtgag gaggggtcag ggggctaagg   7800

atgcaacctc tgacgttctg cgccttccta ggagagtctt acatgtgttg agatttcaca   7860

agcaatgcga gttgtaaaat accagctcta caagaagcta ggctctgtga cggcatagtt   7920

ttcagtagct ttatcacaat attcacaatg gagaattata tgacatggta gcagaaatag   7980

gcccttttat gtgttgcttc tattttacct caaattgtag atatagggta atcaataaaa   8040

tccatccatg cctttcacac actaagt                                       8067


<210>  4681
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  4681

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala 



<210>  4682
<211>  7136
<212>  DNA
<213>  Homo sapiens

<400>  4682
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   1980

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2040

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2100

tgaaaggatc gtccgcggga gtaataaaat caagttcgtt gttaaaaaac ctgaactagt   2160

tatttcctac ttgcctcctg ggatggctag taaaataaac actaaagctt tgcagtcccc   2220

caaaagacca cgaagtcctg ggagtaattc aaaggttcct gaaattgagg tcaccgtgga   2280

aggccctaat aacaacaatc ctcaaacctc agctgttcga accccgaccc agactaacgg   2340

ttctaacgtt cccttcaagc cacgagggag agagttttcc tttgaggcct ggaatgccaa   2400

aatcacggac ctaaaacaga aagttgaaaa tctcttcaat gagaaatgtg gggaagctct   2460

tggccttaaa caagctgtga aggtgccgtt cgcgttattt gagtctttcc cggaagactt   2520

ttatgtggaa ggcttacctg agggtgtgcc attccgaaga ccatcgactt ttggcattcc   2580

gaggctggag aagatactca gaaacaaagc caaaattaag ttcatcatta aaaagcccga   2640

aatgtttgag acggcgatta aggagagcac ctcctctaag agccctccca gaaaaataaa   2700

ttcatcaccc aatgttaata ctactgcatc aggtgttgaa gaccttaaca tcattcaggt   2760

gacaattcca gatgatgata atgaaagact ctcgaaagtt gaaaaagcta gacagctaag   2820

agaacaagtg aatgacctct ttagtcggaa atttggtgaa gctattggta tgggttttcc   2880

tgtgaaagtt ccctacagga aaatcacaat taaccctggc tgtgtggtgg ttgatggcat   2940

gcccccgggg gtgtccttca aagcccccag ctacctggaa atcagctcca tgagaaggat   3000

cttagactct gccgagttta tcaaattcac ggtcattagg taagtgagag tttcctgctt   3060

agtcacagga gcgaatctgg agctcatgag gctgactctt ctaaaatgca gccacaggta   3120

gtcatcgaat ccggcttcct atgctgtgca atcaacaaat caaaataact tgtgtcatca   3180

ttagaatgtc agatgtgctt ctacgaacta agctgactct tttaattctt tggcaaaggg   3240

ttggcaaact aggactgttt gccaaattca ggctgcctcc tatttttaga gtcttcctga   3300

aacacagcta cacccgtatt atccatggct gctttcctgt cacagtgagt aagtagctgg   3360

gactgagaag gcatggcctc caaagtctaa aatatttact ctctagcact ttgtagaaaa   3420

accttagcta ggcacagtgg ctaacgcctg taatcccagc attttgggag gccaaggcag   3480

gcagatcacc tgaggtcagg agttccagac cagcctggcc aacatggtga aatcccatct   3540

ctacaaaaat aaaacagtta gctgggcatg atggcgggtg cctgtaatcc cagctactcg   3600

ggaggctgag gcaggatagt cgcttgaacc caggaggtgg aggttgcaat gagccaagat   3660

catgccactg cactccagcc tggacgacag agtgagactc catcacaaga aaaaaagaac   3720

tttgtcaacc tctgtcttag ggcgccttgt cacaggcttc gggtcagacg gattcaacct   3780

tgcatcagcc atttgttagc caggtcactc tgttctttgt ctgtaaatga gattgatcgt   3840

tgttcccact gagagtgtca gctccttccc gtagagcagg catgatgatt gtactcacct   3900

ctgacaccat tgtgagtgcc acattccttc ccacgtcctt gtcactgtaa gagatgccca   3960

cctgagcacc aaccccaggt tatcttcccc tttgtcttcc agccccccag aaacagctac   4020

gactcaacct acccaatcat ttcatcatca gattgccact gtctctagtt caggtctctt   4080

gggactggca ctcagaaatc tcataataaa tcctcttgag gcttctcata cactcgtctt   4140

cttccaatct tctttccctc aaaatctcat attttggttc cacttcaccc accgtcattc   4200

tccatatcac tcccaggagt taggcaaaaa gccccttccg ttcttccgta tgttaaactt   4260

agaatcactc tgttccctgc tctgcgtttc tattttttgt ttttcctcca tttactagta   4320

gcttaacact ttctaacagt gttcttatta ttgatacgta tctatctctt ccataagctt   4380

ataaggtcac ggataatact tctcattgta gtacgtaaat gacgtgggct agatatgagt   4440

tgaataaaca gttatacctg taaattctta cagagtgaaa ataaattgtt atactttaca   4500

atttgtttct ctctttagac catttccagg acttgtgatt aataaccgtg agtattttgt   4560

gaagtgtttt gtttttgttt tttcctgggg tctgacgtgt gtgcgtgtga gtgtgtatac   4620

atgcttaacg tatatcacgt tacttcacct atgtcagtaa ccaggccaaa tacttgtttt   4680

agccctcagt aaaaacacca ggcacttcct agttgtaaaa ttattcaagc ttcttaactt   4740

cctatcctcg atgcacttaa tcataaaatg gtaataatag caccgatttt gggggagtcg   4800

ttccagtaga tggaaagcat ctggaacagg tgtcagcaag ctcctgccga cgtgtatgca   4860

taaagtttta ttgaaaccac catcgtgtcc atttgtttat ggcagaactg agagatggca   4920

gcagcaagtg tgtgcctgca aaacctaaaa tatttactaa ttggctctgc aagaaaagag   4980

tttgcatccc cctaacctag aacagtgtct agcctctagt atgtgtttag cctacagtat   5040

gtgctcagcg aatacaatct atatttatta ctgcttttat gactgttata attactgtgc   5100

ttggatttcg ttacaaagta agtcacaatg tgcctgcttc tgttagtatt tcagcacagt   5160

gcctggcaca catggggctc tcaaatattg ctgagcgagt gaacaaatgt cctttcaatt   5220

ccttaacgtt gatgtcattt tcaatagtat tttgagccaa acttaatttt gcgagtgtgt   5280

tttgttttct taactttatt attaaaaatg tataaaagtg aggccaggcg tggtggctca   5340

cgcctgtaat cccagcagtt tgggaggctg aggcaggcgg atcagttgag gttgggagtt   5400

ggagaccagc ccgtccaaca tggtgaaagc ctgtctctac taaaaataca aaaatcagct   5460

gggtgtggtg gcgcgtgcct gtaatcccag ctactcagga ggctgaggca ggagagttgc   5520

ttgaatccta gaggtggagg ttgcagtgag ctgagatcgt gccattgcac tccagcctgg   5580

gcaacaagag caaaactctg tcccaataaa taaataaata aaatgttctc ttttgttcct   5640

gttcttgtgc ggtagtgtgg tatagagttt tatggtaatt actgtgaatt agtgattctg   5700

agggacatat cagaactctg aggtttgttt ccttctcatc ttgagggaaa cagcaaatgt   5760

atgttaaaat gcttttccaa gggaacaaca catccttaca ttatttaaac caatctgctt   5820

cattttcaga gctggttgat cagagtgagt cagaaggccc cgtgatacaa gaatcagctg   5880

aaccaagcca gttggaagtt ccagccacag aagaaataaa agagactgat ggaagctctc   5940

agatcaagca agaaccagac cccacgtggt agacctcttc cctcctaggc ttaaagtatc   6000

agtggttgag aagagctttt cggacctgtt actaccccaa gctgtgtaat atacttgtat   6060

aacagaaata ccttctatac aaaccttttt ttctactttt agatagaaat gtctactttt   6120

tcagcagttc tgtgaattaa agagcagagt gactgtgggt ctggaatggc tggtgtactt   6180

gggaatgtac tatcaggatt ttacagcaat gctgggaaat gacagggaaa atgacaggaa   6240

tgaatctcac cagatttttt atgtactcag cagagccttg agttacggtg tttattttcc   6300

aatcaagtga agatatctcc tacttctcct actggaacat ctcagcttct gcagtgaaga   6360

aaaattcctg tgatagttca gttctttagt ttttctattt gaaaaaaaaa aatcatttaa   6420

atgatccttt gttcacggct ctccttaatg actgagtgaa cagttcctat ctgtatattt   6480

gactaaacct tttcctaagc tatctctcat ggttcctatg tttttttatc ataattaaaa   6540

gcaaaaccat ctggatcacc taacagtcag aggtcagtat ctcagcgtgt gaattataga   6600

ggaaatacag agagaacctc ttccactttt acttttcgtc caaataaaat gcatggtgta   6660

ccagaagttg aagatcgggt tgaggattgg ggctagctcg atgacactaa ggccccaaca   6720

tcgcgggacc tgctgtggcg cggattctta ggaacgctgt tctagccggc cccctctcca   6780

ggggtcgccg tggccggcat tatttcctag ttcttcttgt aaccctgagg tgccagcgcg   6840

gggagtgagg aggggtcagg gggctaagga tgcaacctct gacgttctgc gccttcctag   6900

gagagtctta catgtgttga gatttcacaa gcaatgcgag ttgtaaaata ccagctctac   6960

aagaagctag gctctgtgac ggcatagttt tcagtagctt tatcacaata ttcacaatgg   7020

agaattatat gacatggtag cagaaatagg cccttttatg tgttgcttct attttacctc   7080

aaattgtaga tatagggtaa tcaataaaat ccatccatgc ctttcacaca ctaagt       7136


<210>  4683
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  4683

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile 
        515                 520                 525


Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
545                 550                 555                 560


Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys 
                565                 570                 575


Ser Ser Ser Leu Leu Lys Asn Leu Asn 
            580                 585


<210>  4684
<211>  3915
<212>  DNA
<213>  Homo sapiens

<400>  4684
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgcttaga tttgttgaca gcggtttcct ggagtgctgt   1980

cttgagaacg attctgagga ggctcagcaa gaaagagtgt ttcagttgat tgggtgtgtc   2040

tgtcatggag aaggaactca agctcttgga ctcaccgagg cagtaaaagt accatatcct   2100

gtgtttgaat caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc   2160

cgaagcccta cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa   2220

atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct   2280

agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat   2340

tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc   2400

tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg   2460

agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa   2520

aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg   2580

ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg   2640

ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa   2700

gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc   2760

acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca   2820

tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga   2880

ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg   2940

aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca   3000

attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt caaagccccc   3060

agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc   3120

acggtcatta gaccatttcc aggacttgtg attaataacc agctggttga tcagagtgag   3180

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   3240

gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga ccccacgtgg   3300

tagacctctt ccctcctagg caaaaccatc tggatcacct aacagtcaga ggtcagtatc   3360

tcagcgtgtg aattatagag gaaatacaga gagaacctct tccactttta cttttcgtcc   3420

aaataaaatg catggtgtac cagaagttga agatcgggtt gaggattggg gctagctcga   3480

tgacactaag gccccaacat cgcgggacct gctgtggcgc ggattcttag gaacgctgtt   3540

ctagccggcc ccctctccag gggtcgccgt ggccggcatt atttcctagt tcttcttgta   3600

accctgaggt gccagcgcgg ggagtgagga ggggtcaggg ggctaaggat gcaacctctg   3660

acgttctgcg ccttcctagg agagtcttac atgtgttgag atttcacaag caatgcgagt   3720

tgtaaaatac cagctctaca agaagctagg ctctgtgacg gcatagtttt cagtagcttt   3780

atcacaatat tcacaatgga gaattatatg acatggtagc agaaataggc ccttttatgt   3840

gttgcttcta ttttacctca aattgtagat atagggtaat caataaaatc catccatgcc   3900

tttcacacac taagt                                                    3915


<210>  4685
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  4685

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
            420                 425                 430


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
        435                 440                 445


Phe Asn Leu Lys Phe Ala 
    450


<210>  4686
<211>  4306
<212>  DNA
<213>  Homo sapiens

<400>  4686
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   2040

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   2100

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2160

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2220

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2280

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2340

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2400

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2460

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2520

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2580

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2640

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2700

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2760

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2820

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2880

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2940

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   3000

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   3060

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3120

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3180

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3240

ttcacggtca ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt   3300

gagtcagaag gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc   3360

acagaagaaa taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg   3420

tggtagacct cttccctcct aggagccttg agttacggtg tttattttcc aatcaagtga   3480

agatatctcc tacttctcct actggaacat ctcagcttct gcagtgaaga aaaattcctg   3540

tgatagttca gttctttagt ttttctattt gaaaaaaaaa aatcatttaa atgatccttt   3600

gttcacggct ctccttaatg actgagtgaa cagttcctat ctgtatattt gactaaacct   3660

tttcctaagc tatctctcat ggttcctatg tttttttatc ataattaaaa gcaaaaccat   3720

ctggatcacc taacagtcag aggtcagtat ctcagcgtgt gaattataga ggaaatacag   3780

agagaacctc ttccactttt acttttcgtc caaataaaat gcatggtgta ccagaagttg   3840

aagatcgggt tgaggattgg ggctagctcg atgacactaa ggccccaaca tcgcgggacc   3900

tgctgtggcg cggattctta ggaacgctgt tctagccggc cccctctcca ggggtcgccg   3960

tggccggcat tatttcctag ttcttcttgt aaccctgagg tgccagcgcg gggagtgagg   4020

aggggtcagg gggctaagga tgcaacctct gacgttctgc gccttcctag gagagtctta   4080

catgtgttga gatttcacaa gcaatgcgag ttgtaaaata ccagctctac aagaagctag   4140

gctctgtgac ggcatagttt tcagtagctt tatcacaata ttcacaatgg agaattatat   4200

gacatggtag cagaaatagg cccttttatg tgttgcttct attttacctc aaattgtaga   4260

tatagggtaa tcaataaaat ccatccatgc ctttcacaca ctaagt                  4306


<210>  4687
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  4687

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
465                 470                 475                 480


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
                485                 490                 495


<210>  4688
<211>  4238
<212>  DNA
<213>  Homo sapiens

<400>  4688
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2040

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2100

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2160

tgaatcaaac ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag   2220

ccctacctgg tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa   2280

gttcgttgtt aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa   2340

aataaacact aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa   2400

ggttcctgaa attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc   2460

tgttcgaacc ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga   2520

gttttccttt gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct   2580

cttcaatgag aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc   2640

gttatttgag tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt   2700

ccgaagacca tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa   2760

aattaagttc atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc   2820

ctctaagagc cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg   2880

tgttgaagac cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc   2940

gaaagttgaa aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt   3000

tggtgaagct attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa   3060

ccctggctgt gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta   3120

cctggaaatc agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt   3180

cattagacca tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga   3240

aggccccgtg atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga   3300

aataaaagag actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac   3360

ctcttccctc ctaggagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct   3420

cctacttctc ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt   3480

cagttcttta gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg   3540

ctctccttaa tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa   3600

gctatctctc atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca   3660

cctaacagtc agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc   3720

tcttccactt ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg   3780

gttgaggatt ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg   3840

cgcggattct taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc   3900

attatttcct agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca   3960

gggggctaag gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt   4020

gagatttcac aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg   4080

acggcatagt tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt   4140

agcagaaata ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt   4200

aatcaataaa atccatccat gcctttcaca cactaagt                           4238


<210>  4689
<211>  978
<212>  PRT
<213>  Homo sapiens

<400>  4689

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu 
            580                 585                 590


Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg 
        595                 600                 605


Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys 
    610                 615                 620


Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys 
625                 630                 635                 640


Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly 
                645                 650                 655


Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn 
            660                 665                 670


Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn 
        675                 680                 685


Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu 
    690                 695                 700


Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu 
705                 710                 715                 720


Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys 
                725                 730                 735


Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu 
            740                 745                 750


Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile 
        755                 760                 765


Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile 
    770                 775                 780


Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser 
785                 790                 795                 800


Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr 
                805                 810                 815


Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro 
            820                 825                 830


Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu 
        835                 840                 845


Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile 
    850                 855                 860


Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn 
865                 870                 875                 880


Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys 
                885                 890                 895


Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser 
            900                 905                 910


Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val 
        915                 920                 925


Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile 
    930                 935                 940


Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu 
945                 950                 955                 960


Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro 
                965                 970                 975


Thr Trp 



<210>  4690
<211>  5093
<212>  DNA
<213>  Homo sapiens

<400>  4690
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   2040

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2100

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2160

atcaaacccg gagttcttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2220

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2280

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2340

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2400

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2460

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2520

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2580

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2640

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2700

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2760

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2820

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2880

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2940

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   3000

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3060

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca   3120

tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg   3180

atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaagg taaaaggacc   3240

tcttccctcc tagggtaaat cagcttctgt gtcagggatg ctgtgtggtg tccatctgaa   3300

ccccctgcat acgcgtagct aatgtgatct ccccactttc acataagatg gtggccctgc   3360

cttcagggaa tgtgggagcc aggtgggagc cttcccggat atttaagcta gaagattcta   3420

cagggagatt ctccttggat caatatatgt ctctcagtca aagatgtaaa agcacttttg   3480

ccttaaaaag aatgttctgt ttctaaatag agtcaacgtt gtcctcctca ttggaattca   3540

ctatgagtca gaatcattag actgactttt ttttttccat agtaatagta ttttgcagag   3600

tctcacagag ctgcagatct tttgttcatc ttgcagagtt aacaagtctg atcctgttag   3660

tccagatttc ttaaatttgg ccaagttata ataggagcag tagcttgaga cccgaagtca   3720

ggaaactttg acaatggatt ttttttttta atccagagac ttgtactgga atttgcctta   3780

ccctgtcagc tcatggactt aaggtttcat cccgctttat gagtgcttct gaatccaagt   3840

cattgttacc tgaatttgca aattaagttg tgatattcgt gactgttaaa ttcctgtaat   3900

tagattaacc tctttgcttg cttgtttgtt ttctctccta ttttagctta aagtatcagt   3960

ggttgagaag agcttttcgg acctgttact accccaagct gtgtaatata cttgtataac   4020

agaaatacct tctatacaaa cctttttttc tacttttaga tagaaatgtc tactttttca   4080

gcagttctgt gaattaaaga gcagagtgac tgtgggtctg gaatggctgg tgtacttggg   4140

aatgtactat caggatttta cagcaatgct gggaaatgac agggaaaatg acaggaatga   4200

atctcaccag attttttatg tactcagcag agccttgagt tacggtgttt attttccaat   4260

caagtgaaga tatctcctac ttctcctact ggaacatctc agcttctgca gtgaagaaaa   4320

attcctgtga tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat catttaaatg   4380

atcctttgtt cacggctctc cttaatgact gagtgaacag ttcctatctg tatatttgac   4440

taaacctttt cctaagctat ctctcatggt tcctatgttt ttttatcata attaaaagca   4500

aaaccatctg gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa ttatagagga   4560

aatacagaga gaacctcttc cacttttact tttcgtccaa ataaaatgca tggtgtacca   4620

gaagttgaag atcgggttga ggattggggc tagctcgatg acactaaggc cccaacatcg   4680

cgggacctgc tgtggcgcgg attcttagga acgctgttct agccggcccc ctctccaggg   4740

gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg   4800

agtgaggagg ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc ttcctaggag   4860

agtcttacat gtgttgagat ttcacaagca atgcgagttg taaaatacca gctctacaag   4920

aagctaggct ctgtgacggc atagttttca gtagctttat cacaatattc acaatggaga   4980

attatatgac atggtagcag aaataggccc ttttatgtgt tgcttctatt ttacctcaaa   5040

ttgtagatat agggtaatca ataaaatcca tccatgcctt tcacacacta agt          5093


<210>  4691
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  4691

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
                565                 570                 575


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly 
            580                 585                 590


Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600


<210>  4692
<211>  4147
<212>  DNA
<213>  Homo sapiens

<400>  4692
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   1980

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2040

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2100

tgaaaggatc gtccgcggga gtaataaaat caagttcgtt gttaaaaaac ctgaactagt   2160

tatttcctac ttgcctcctg ggatggctag taaaataaac actaaagctt tgcagtcccc   2220

caaaagacca cgaagtcctg ggagtaattc aaaggttcct gaaattgagg tcaccgtgga   2280

aggccctaat aacaacaatc ctcaaacctc agctgttcga accccgaccc agactaacgg   2340

ttctaacgtt cccttcaagc cacgagggag agagttttcc tttgaggcct ggaatgccaa   2400

aatcacggac ctaaaacaga aagttgaaaa tctcttcaat gagaaatgtg gggaagctct   2460

tggccttaaa caagctgtga aggtgccgtt cgcgttattt gagtctttcc cggaagactt   2520

ttatgtggaa ggcttacctg agggtgtgcc attccgaaga ccatcgactt ttggcattcc   2580

gaggctggag aagatactca gaaacaaagc caaaattaag ttcatcatta aaaagcccga   2640

aatgtttgag acggcgatta aggagagcac ctcctctaag agccctccca gaaaaataaa   2700

ttcatcaccc aatgttaata ctactgcatc aggtgttgaa gaccttaaca tcattcaggt   2760

gacaattcca gatgatgata atgaaagact ctcgaaagtt gaaaaagcta gacagctaag   2820

agaacaagtg aatgacctct ttagtcggaa atttggtgaa gctattggta tgggttttcc   2880

tgtgaaagtt ccctacagga aaatcacaat taaccctggc tgtgtggtgg ttgatggcat   2940

gcccccgggg gtgtccttca aagcccccag ctacctggaa atcagctcca tgagaaggat   3000

cttagactct gccgagttta tcaaattcac ggtcattaga ccatttccag gacttgtgat   3060

taataaccag ctggttgatc agagtgagtc agaaggcccc gtgatacaag aatcagctga   3120

accaagccag ttggaagttc cagccacaga agaaataaaa gagactgatg gaagctctca   3180

gatcaagcaa gaaccagacc ccacgtggta gacctcttcc ctcctaggct taaagtatca   3240

gtggttgaga agagcttttc ggacctgtta ctaccccaag ctgtagcctt gagttacggt   3300

gtttattttc caatcaagtg aagatatctc ctacttctcc tactggaaca tctcagcttc   3360

tgcagtgaag aaaaattcct gtgatagttc agttctttag tttttctatt tgaaaaaaaa   3420

aaatcattta aatgatcctt tgttcacggc tctccttaat gactgagtga acagttccta   3480

tctgtatatt tgactaaacc ttttcctaag ctatctctca tggttcctat gtttttttat   3540

cataattaaa agcaaaacca tctggatcac ctaacagtca gaggtcagta tctcagcgtg   3600

tgaattatag aggaaataca gagagaacct cttccacttt tacttttcgt ccaaataaaa   3660

tgcatggtgt accagaagtt gaagatcggg ttgaggattg gggctagctc gatgacacta   3720

aggccccaac atcgcgggac ctgctgtggc gcggattctt aggaacgctg ttctagccgg   3780

ccccctctcc aggggtcgcc gtggccggca ttatttccta gttcttcttg taaccctgag   3840

gtgccagcgc ggggagtgag gaggggtcag ggggctaagg atgcaacctc tgacgttctg   3900

cgccttccta ggagagtctt acatgtgttg agatttcaca agcaatgcga gttgtaaaat   3960

accagctcta caagaagcta ggctctgtga cggcatagtt ttcagtagct ttatcacaat   4020

attcacaatg gagaattata tgacatggta gcagaaatag gcccttttat gtgttgcttc   4080

tattttacct caaattgtag atatagggta atcaataaaa tccatccatg cctttcacac   4140

actaagt                                                             4147


<210>  4693
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  4693

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile 
        515                 520                 525


Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
545                 550                 555                 560


Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys 
                565                 570                 575


Ser Ser Ser Leu Leu Lys Asn Leu Asn 
            580                 585


<210>  4694
<211>  4274
<212>  DNA
<213>  Homo sapiens

<400>  4694
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   2040

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2100

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2160

tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg tttggaattc   2220

cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg   2280

aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc   2340

agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca   2400

ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga   2460

ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga   2520

atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg   2580

aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg   2640

aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg   2700

gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa   2760

agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa   2820

aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca   2880

ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac   2940

agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg   3000

gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg   3060

atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga   3120

gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca tttccaggac   3180

ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat   3240

cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa   3300

gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc ctaggcttaa   3360

agtatcagtg gttgagaaga gcttttcgga cctgttacta ccccaagctg tagccttgag   3420

ttacggtgtt tattttccaa tcaagtgaag atatctccta cttctcctac tggaacatct   3480

cagcttctgc agtgaagaaa aattcctgtg atagttcagt tctttagttt ttctatttga   3540

aaaaaaaaaa tcatttaaat gatcctttgt tcacggctct ccttaatgac tgagtgaaca   3600

gttcctatct gtatatttga ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt   3660

tttttatcat aattaaaagc aaaaccatct ggatcaccta acagtcagag gtcagtatct   3720

cagcgtgtga attatagagg aaatacagag agaacctctt ccacttttac ttttcgtcca   3780

aataaaatgc atggtgtacc agaagttgaa gatcgggttg aggattgggg ctagctcgat   3840

gacactaagg ccccaacatc gcgggacctg ctgtggcgcg gattcttagg aacgctgttc   3900

tagccggccc cctctccagg ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa   3960

ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg gctaaggatg caacctctga   4020

cgttctgcgc cttcctagga gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt   4080

gtaaaatacc agctctacaa gaagctaggc tctgtgacgg catagttttc agtagcttta   4140

tcacaatatt cacaatggag aattatatga catggtagca gaaataggcc cttttatgtg   4200

ttgcttctat tttacctcaa attgtagata tagggtaatc aataaaatcc atccatgcct   4260

ttcacacact aagt                                                     4274


<210>  4695
<211>  978
<212>  PRT
<213>  Homo sapiens

<400>  4695

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu 
            580                 585                 590


Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg 
        595                 600                 605


Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys 
    610                 615                 620


Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys 
625                 630                 635                 640


Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly 
                645                 650                 655


Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn 
            660                 665                 670


Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn 
        675                 680                 685


Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu 
    690                 695                 700


Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu 
705                 710                 715                 720


Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys 
                725                 730                 735


Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu 
            740                 745                 750


Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile 
        755                 760                 765


Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile 
    770                 775                 780


Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser 
785                 790                 795                 800


Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr 
                805                 810                 815


Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro 
            820                 825                 830


Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu 
        835                 840                 845


Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile 
    850                 855                 860


Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn 
865                 870                 875                 880


Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys 
                885                 890                 895


Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser 
            900                 905                 910


Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val 
        915                 920                 925


Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile 
    930                 935                 940


Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu 
945                 950                 955                 960


Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro 
                965                 970                 975


Thr Trp 



<210>  4696
<211>  5255
<212>  DNA
<213>  Homo sapiens

<400>  4696
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   2040

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gcttagattt   2100

gttgacagcg gtttcctgga gtgctgtctt gagaacgatt ctgaggaggc tcagcaagaa   2160

agagtgtttc agttgattgg gtgtgtctgt catggagaag gaactcaagc tcttggactc   2220

accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgtatgtg   2280

gaaggcttgc cagaggggat tcccttccga agccctacct ggtttggaat tccacgactt   2340

gaaaggatcg tccgcgggag taataaaatc aagttcgttg ttaaaaaacc tgaactagtt   2400

atttcctact tgcctcctgg gatggctagt aaaataaaca ctaaagcttt gcagtccccc   2460

aaaagaccac gaagtcctgg gagtaattca aaggttcctg aaattgaggt caccgtggaa   2520

ggccctaata acaacaatcc tcaaacctca gctgttcgaa ccccgaccca gactaacggt   2580

tctaacgttc ccttcaagcc acgagggaga gagttttcct ttgaggcctg gaatgccaaa   2640

atcacggacc taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg ggaagctctt   2700

ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg agtctttccc ggaagacttt   2760

tatgtggaag gcttacctga gggtgtgcca ttccgaagac catcgacttt tggcattccg   2820

aggctggaga agatactcag aaacaaagcc aaaattaagt tcatcattaa aaagcccgaa   2880

atgtttgaga cggcgattaa ggagagcacc tcctctaaga gccctcccag aaaaataaat   2940

tcatcaccca atgttaatac tactgcatca ggtgttgaag accttaacat cattcaggtg   3000

acaattccag atgatgataa tgaaagactc tcgaaagttg aaaaagctag acagctaaga   3060

gaacaagtga atgacctctt tagtcggaaa tttggtgaag ctattggtat gggttttcct   3120

gtgaaagttc cctacaggaa aatcacaatt aaccctggct gtgtggtggt tgatggcatg   3180

cccccggggg tgtccttcaa agcccccagc tacctggaaa tcagctccat gagaaggatc   3240

ttagactctg ccgagtttat caaattcacg gtcattagac catttccagg acttgtgatt   3300

aataaccagc tggttgatca gagtgagtca gaaggccccg tgatacaaga atcagctgaa   3360

ccaagccagt tggaagttcc agccacagaa ggtaaaagga cctcttccct cctagggtaa   3420

atcagcttct gtgtcaggga tgctgtgtgg tgtccatctg aaccccctgc atacgcgtag   3480

ctaatgtgat ctccccactt tcacataaga tggtggccct gccttcaggg aatgtgggag   3540

ccaggtggga gccttcccgg atatttaagc tagaagattc tacagggaga ttctccttgg   3600

atcaatatat gtctctcagt caaagatgta aaagcacttt tgccttaaaa agaatgttct   3660

gtttctaaat agagtcaacg ttgtcctcct cattggaatt cactatgagt cagaatcatt   3720

agactgactt ttttttttcc atagtaatag tattttgcag agtctcacag agctgcagat   3780

cttttgttca tcttgcagag ttaacaagtc tgatcctgtt agtccagatt tcttaaattt   3840

ggccaagtta taataggagc agtagcttga gacccgaagt caggaaactt tgacaatgga   3900

tttttttttt taatccagag acttgtactg gaatttgcct taccctgtca gctcatggac   3960

ttaaggtttc atcccgcttt atgagtgctt ctgaatccaa gtcattgtta cctgaatttg   4020

caaattaagt tgtgatattc gtgactgtta aattcctgta attagattaa cctctttgct   4080

tgcttgtttg ttttctctcc tattttagct taaagtatca gtggttgaga agagcttttc   4140

ggacctgtta ctaccccaag ctgtgtaata tacttgtata acagaaatac cttctataca   4200

aacctttttt tctactttta gatagaaatg tctacttttt cagcagttct gtgaattaaa   4260

gagcagagtg actgtgggtc tggaatggct ggtgtacttg ggaatgtact atcaggattt   4320

tacagcaatg ctgggaaatg acagggaaaa tgacaggaat gaatctcacc agatttttta   4380

tgtactcagc agagccttga gttacggtgt ttattttcca atcaagtgaa gatatctcct   4440

acttctccta ctggaacatc tcagcttctg cagtgaagaa aaattcctgt gatagttcag   4500

ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa tgatcctttg ttcacggctc   4560

tccttaatga ctgagtgaac agttcctatc tgtatatttg actaaacctt ttcctaagct   4620

atctctcatg gttcctatgt ttttttatca taattaaaag caaaaccatc tggatcacct   4680

aacagtcaga ggtcagtatc tcagcgtgtg aattatagag gaaatacaga gagaacctct   4740

tccactttta cttttcgtcc aaataaaatg catggtgtac cagaagttga agatcgggtt   4800

gaggattggg gctagctcga tgacactaag gccccaacat cgcgggacct gctgtggcgc   4860

ggattcttag gaacgctgtt ctagccggcc ccctctccag gggtcgccgt ggccggcatt   4920

atttcctagt tcttcttgta accctgaggt gccagcgcgg ggagtgagga ggggtcaggg   4980

ggctaaggat gcaacctctg acgttctgcg ccttcctagg agagtcttac atgtgttgag   5040

atttcacaag caatgcgagt tgtaaaatac cagctctaca agaagctagg ctctgtgacg   5100

gcatagtttt cagtagcttt atcacaatat tcacaatgga gaattatatg acatggtagc   5160

agaaataggc ccttttatgt gttgcttcta ttttacctca aattgtagat atagggtaat   5220

caataaaatc catccatgcc tttcacacac taagt                              5255


<210>  4697
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  4697

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala 



<210>  4698
<211>  3999
<212>  DNA
<213>  Homo sapiens

<400>  4698
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1980

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct tagatttgtt   2040

gacagcggtt tcctggagtg ctgtcttgag aacgattctg aggaggctca gcaagaaaga   2100

gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa ctcaagctct tggactcacc   2160

gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc cggagttctt gtatgtggaa   2220

ggcttgccag aggggattcc cttccgaagc cctacctggt ttggaattcc acgacttgaa   2280

aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta aaaaacctga actagttatt   2340

tcctacttgc ctcctgggat ggctagtaaa ataaacacta aagctttgca gtcccccaaa   2400

agaccacgaa gtcctgggag taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc   2460

cctaataaca acaatcctca aacctcagct gttcgaaccc cgacccagac taacggttct   2520

aacgttccct tcaagccacg agggagagag ttttcctttg aggcctggaa tgccaaaatc   2580

acggacctaa aacagaaagt tgaaaatctc ttcaatgaga aatgtgggga agctcttggc   2640

cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt ctttcccgga agacttttat   2700

gtggaaggct tacctgaggg tgtgccattc cgaagaccat cgacttttgg cattccgagg   2760

ctggagaaga tactcagaaa caaagccaaa attaagttca tcattaaaaa gcccgaaatg   2820

tttgagacgg cgattaagga gagcacctcc tctaagagcc ctcccagaaa aataaattca   2880

tcacccaatg ttaatactac tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca   2940

attccagatg atgataatga aagactctcg aaagttgaaa aagctagaca gctaagagaa   3000

caagtgaatg acctctttag tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg   3060

aaagttccct acaggaaaat cacaattaac cctggctgtg tggtggttga tggcatgccc   3120

ccgggggtgt ccttcaaagc ccccagctac ctggaaatca gctccatgag aaggatctta   3180

gactctgccg agtttatcaa attcacggtc attagaccat ttccaggact tgtgattaat   3240

aaccagctgg ttgatcagag tgagtcagaa ggccccgtga tacaagaatc agctgaacca   3300

agccagttgg aagttccagc cacagaagaa ataaaagaga ctgatggaag ctctcagatc   3360

aagcaagaac cagaccccac gtggtagacc tcttccctcc taggcaaaac catctggatc   3420

acctaacagt cagaggtcag tatctcagcg tgtgaattat agaggaaata cagagagaac   3480

ctcttccact tttacttttc gtccaaataa aatgcatggt gtaccagaag ttgaagatcg   3540

ggttgaggat tggggctagc tcgatgacac taaggcccca acatcgcggg acctgctgtg   3600

gcgcggattc ttaggaacgc tgttctagcc ggccccctct ccaggggtcg ccgtggccgg   3660

cattatttcc tagttcttct tgtaaccctg aggtgccagc gcggggagtg aggaggggtc   3720

agggggctaa ggatgcaacc tctgacgttc tgcgccttcc taggagagtc ttacatgtgt   3780

tgagatttca caagcaatgc gagttgtaaa ataccagctc tacaagaagc taggctctgt   3840

gacggcatag ttttcagtag ctttatcaca atattcacaa tggagaatta tatgacatgg   3900

tagcagaaat aggccctttt atgtgttgct tctattttac ctcaaattgt agatataggg   3960

taatcaataa aatccatcca tgcctttcac acactaagt                          3999


<210>  4699
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  4699

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  4700
<211>  3898
<212>  DNA
<213>  Homo sapiens

<400>  4700
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagc   2040

tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc   2100

ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc ctacctggtt   2160

tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa   2220

aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa taaacactaa   2280

agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg ttcctgaaat   2340

tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg ttcgaacccc   2400

gacccagact aacggttcta acgttccctt caagccacga gggagagagt tttcctttga   2460

ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct tcaatgagaa   2520

atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc   2580

tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc gaagaccatc   2640

gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa ttaagttcat   2700

cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct ctaagagccc   2760

tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg ttgaagacct   2820

taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga aagttgaaaa   2880

agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg gtgaagctat   2940

tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc ctggctgtgt   3000

ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc tggaaatcag   3060

ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca ttagaccatt   3120

tccaggactt gtgattaata accagctggt tgatcagagt gagtcagaag gccccgtgat   3180

acaagaatca gctgaaccaa gccagttgga agttccagcc acagaagaaa taaaagagac   3240

tgatggaagc tctcagatca agcaagaacc agaccccacg tggtagacct cttccctcct   3300

aggcaaaacc atctggatca cctaacagtc agaggtcagt atctcagcgt gtgaattata   3360

gaggaaatac agagagaacc tcttccactt ttacttttcg tccaaataaa atgcatggtg   3420

taccagaagt tgaagatcgg gttgaggatt ggggctagct cgatgacact aaggccccaa   3480

catcgcggga cctgctgtgg cgcggattct taggaacgct gttctagccg gccccctctc   3540

caggggtcgc cgtggccggc attatttcct agttcttctt gtaaccctga ggtgccagcg   3600

cggggagtga ggaggggtca gggggctaag gatgcaacct ctgacgttct gcgccttcct   3660

aggagagtct tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa taccagctct   3720

acaagaagct aggctctgtg acggcatagt tttcagtagc tttatcacaa tattcacaat   3780

ggagaattat atgacatggt agcagaaata ggccctttta tgtgttgctt ctattttacc   3840

tcaaattgta gatatagggt aatcaataaa atccatccat gcctttcaca cactaagt     3898


<210>  4701
<211>  954
<212>  PRT
<213>  Homo sapiens

<400>  4701

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly 
    530                 535                 540


Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro 
545                 550                 555                 560


Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser 
                565                 570                 575


Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser 
            580                 585                 590


Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr 
        595                 600                 605


Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser 
    610                 615                 620


Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile 
625                 630                 635                 640


Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala 
                645                 650                 655


Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro 
            660                 665                 670


Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp 
        675                 680                 685


Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala 
    690                 695                 700


Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser 
705                 710                 715                 720


Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe 
                725                 730                 735


Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg 
            740                 745                 750


Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu 
        755                 760                 765


Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile 
    770                 775                 780


Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu 
785                 790                 795                 800


Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser 
                805                 810                 815


Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe 
            820                 825                 830


Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val 
        835                 840                 845


Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly 
    850                 855                 860


Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser 
865                 870                 875                 880


Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val 
                885                 890                 895


Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln 
            900                 905                 910


Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln 
        915                 920                 925


Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser 
    930                 935                 940


Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  4702
<211>  3796
<212>  DNA
<213>  Homo sapiens

<400>  4702
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1980

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   2040

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   2100

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2160

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2220

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2280

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2340

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2400

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2460

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2520

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2580

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2640

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2700

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2760

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2820

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2880

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2940

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   3000

cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg atcagagtga   3060

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   3120

agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag accccacgtg   3180

gtagacctct tccctcctag gcaaaaccat ctggatcacc taacagtcag aggtcagtat   3240

ctcagcgtgt gaattataga ggaaatacag agagaacctc ttccactttt acttttcgtc   3300

caaataaaat gcatggtgta ccagaagttg aagatcgggt tgaggattgg ggctagctcg   3360

atgacactaa ggccccaaca tcgcgggacc tgctgtggcg cggattctta ggaacgctgt   3420

tctagccggc cccctctcca ggggtcgccg tggccggcat tatttcctag ttcttcttgt   3480

aaccctgagg tgccagcgcg gggagtgagg aggggtcagg gggctaagga tgcaacctct   3540

gacgttctgc gccttcctag gagagtctta catgtgttga gatttcacaa gcaatgcgag   3600

ttgtaaaata ccagctctac aagaagctag gctctgtgac ggcatagttt tcagtagctt   3660

tatcacaata ttcacaatgg agaattatat gacatggtag cagaaatagg cccttttatg   3720

tgttgcttct attttacctc aaattgtaga tatagggtaa tcaataaaat ccatccatgc   3780

ctttcacaca ctaagt                                                   3796


<210>  4703
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  4703

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
    450                 455                 460


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
465                 470                 475                 480


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
                485                 490                 495


Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys 
            500                 505                 510


Asn Leu Asn 
        515


<210>  4704
<211>  4435
<212>  DNA
<213>  Homo sapiens

<400>  4704
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   2040

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2100

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2160

tgaaaggatc gtccgcggga gtaataaaat caagttcgtt gttaaaaaac ctgaactagt   2220

tatttcctac ttgcctcctg ggatggctag taaaataaac actaaagctt tgcagtcccc   2280

caaaagacca cgaagtcctg ggagtaattc aaaggttcct gaaattgagg tcaccgtgga   2340

aggccctaat aacaacaatc ctcaaacctc agctgttcga accccgaccc agactaacgg   2400

ttctaacgtt cccttcaagc cacgagggag agagttttcc tttgaggcct ggaatgccaa   2460

aatcacggac ctaaaacaga aagttgaaaa tctcttcaat gagaaatgtg gggaagctct   2520

tggccttaaa caagctgtga aggtgccgtt cgcgttattt gagtctttcc cggaagactt   2580

ttatgtggaa ggcttacctg agggtgtgcc attccgaaga ccatcgactt ttggcattcc   2640

gaggctggag aagatactca gaaacaaagc caaaattaag ttcatcatta aaaagcccga   2700

aatgtttgag acggcgatta aggagagcac ctcctctaag agccctccca gaaaaataaa   2760

ttcatcaccc aatgttaata ctactgcatc aggtgttgaa gaccttaaca tcattcaggt   2820

gacaattcca gatgatgata atgaaagact ctcgaaagtt gaaaaagcta gacagctaag   2880

agaacaagtg aatgacctct ttagtcggaa atttggtgaa gctattggta tgggttttcc   2940

tgtgaaagtt ccctacagga aaatcacaat taaccctggc tgtgtggtgg ttgatggcat   3000

gcccccgggg gtgtccttca aagcccccag ctacctggaa atcagctcca tgagaaggat   3060

cttagactct gccgagttta tcaaattcac ggtcattaga ccatttccag gacttgtgat   3120

taataaccag ctggttgatc agagtgagtc agaaggcccc gtgatacaag aatcagctga   3180

accaagccag ttggaagttc cagccacaga agaaataaaa gagactgatg gaagctctca   3240

gatcaagcaa gaaccagacc ccacgtggta gacctcttcc ctcctaggct taaagtatca   3300

gtggttgaga agagcttttc ggacctgtta ctaccccaag ctgtgtaata tacttgtata   3360

acagaaatac cttctataca aacctttttt tctactttta gatagaaatg tctacttttt   3420

cagcagttct gtgaattaaa gagcagagtg actgtgggtc tggaatggct ggtgtacttg   3480

ggaatgtact atcaggattt tacagcaatg ctgggaaatg acagggaaaa tgacaggaat   3540

gaatctcacc agatttttta tgtactcagc agagccttga gttacggtgt ttattttcca   3600

atcaagtgaa gatatctcct acttctccta ctggaacatc tcagcttctg cagtgaagaa   3660

aaattcctgt gatagttcag ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa   3720

tgatcctttg ttcacggctc tccttaatga ctgagtgaac agttcctatc tgtatatttg   3780

actaaacctt ttcctaagct atctctcatg gttcctatgt ttttttatca taattaaaag   3840

caaaaccatc tggatcacct aacagtcaga ggtcagtatc tcagcgtgtg aattatagag   3900

gaaatacaga gagaacctct tccactttta cttttcgtcc aaataaaatg catggtgtac   3960

cagaagttga agatcgggtt gaggattggg gctagctcga tgacactaag gccccaacat   4020

cgcgggacct gctgtggcgc ggattcttag gaacgctgtt ctagccggcc ccctctccag   4080

gggtcgccgt ggccggcatt atttcctagt tcttcttgta accctgaggt gccagcgcgg   4140

ggagtgagga ggggtcaggg ggctaaggat gcaacctctg acgttctgcg ccttcctagg   4200

agagtcttac atgtgttgag atttcacaag caatgcgagt tgtaaaatac cagctctaca   4260

agaagctagg ctctgtgacg gcatagtttt cagtagcttt atcacaatat tcacaatgga   4320

gaattatatg acatggtagc agaaataggc ccttttatgt gttgcttcta ttttacctca   4380

aattgtagat atagggtaat caataaaatc catccatgcc tttcacacac taagt        4435


<210>  4705
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  4705

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala 
            580                 585                 590


Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600                 605


<210>  4706
<211>  4347
<212>  DNA
<213>  Homo sapiens

<400>  4706
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   2040

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2100

gaaatttgct tagatttgtt gacagcggtt tcctggagtg ctgtcttgag aacgattctg   2160

aggaggctca gcaagaaaga gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa   2220

ctcaagctct tggactcacc gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc   2280

cggagttctt gtatgtggaa ggcttgccag aggggattcc cttccgaagc cctacctggt   2340

ttggaattcc acgacttgaa aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta   2400

aaaaacctga actagttatt tcctacttgc ctcctgggat ggctagtaaa ataaacacta   2460

aagctttgca gtcccccaaa agaccacgaa gtcctgggag taattcaaag gttcctgaaa   2520

ttgaggtcac cgtggaaggc cctaataaca acaatcctca aacctcagct gttcgaaccc   2580

cgacccagac taacggttct aacgttccct tcaagccacg agggagagag ttttcctttg   2640

aggcctggaa tgccaaaatc acggacctaa aacagaaagt tgaaaatctc ttcaatgaga   2700

aatgtgggga agctcttggc cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt   2760

ctttcccgga agacttttat gtggaaggct tacctgaggg tgtgccattc cgaagaccat   2820

cgacttttgg cattccgagg ctggagaaga tactcagaaa caaagccaaa attaagttca   2880

tcattaaaaa gcccgaaatg tttgagacgg cgattaagga gagcacctcc tctaagagcc   2940

ctcccagaaa aataaattca tcacccaatg ttaatactac tgcatcaggt gttgaagacc   3000

ttaacatcat tcaggtgaca attccagatg atgataatga aagactctcg aaagttgaaa   3060

aagctagaca gctaagagaa caagtgaatg acctctttag tcggaaattt ggtgaagcta   3120

ttggtatggg ttttcctgtg aaagttccct acaggaaaat cacaattaac cctggctgtg   3180

tggtggttga tggcatgccc ccgggggtgt ccttcaaagc ccccagctac ctggaaatca   3240

gctccatgag aaggatctta gactctgccg agtttatcaa attcacggtc attagaccat   3300

ttccaggact tgtgattaat aaccagctgg ttgatcagag tgagtcagaa ggccccgtga   3360

tacaagaatc agctgaacca agccagttgg aagttccagc cacagaagaa ataaaagaga   3420

ctgatggaag ctctcagatc aagcaagaac cagaccccac gtggtagacc tcttccctcc   3480

taggagcctt gagttacggt gtttattttc caatcaagtg aagatatctc ctacttctcc   3540

tactggaaca tctcagcttc tgcagtgaag aaaaattcct gtgatagttc agttctttag   3600

tttttctatt tgaaaaaaaa aaatcattta aatgatcctt tgttcacggc tctccttaat   3660

gactgagtga acagttccta tctgtatatt tgactaaacc ttttcctaag ctatctctca   3720

tggttcctat gtttttttat cataattaaa agcaaaacca tctggatcac ctaacagtca   3780

gaggtcagta tctcagcgtg tgaattatag aggaaataca gagagaacct cttccacttt   3840

tacttttcgt ccaaataaaa tgcatggtgt accagaagtt gaagatcggg ttgaggattg   3900

gggctagctc gatgacacta aggccccaac atcgcgggac ctgctgtggc gcggattctt   3960

aggaacgctg ttctagccgg ccccctctcc aggggtcgcc gtggccggca ttatttccta   4020

gttcttcttg taaccctgag gtgccagcgc ggggagtgag gaggggtcag ggggctaagg   4080

atgcaacctc tgacgttctg cgccttccta ggagagtctt acatgtgttg agatttcaca   4140

agcaatgcga gttgtaaaat accagctcta caagaagcta ggctctgtga cggcatagtt   4200

ttcagtagct ttatcacaat attcacaatg gagaattata tgacatggta gcagaaatag   4260

gcccttttat gtgttgcttc tattttacct caaattgtag atatagggta atcaataaaa   4320

tccatccatg cctttcacac actaagt                                       4347


<210>  4707
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  4707

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala 



<210>  4708
<211>  7905
<212>  DNA
<213>  Homo sapiens

<400>  4708
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   2040

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2100

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2160

atcaaacccg gagttcttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2220

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2280

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2340

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2400

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2460

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2520

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2580

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2640

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2700

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2760

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2820

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2880

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2940

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   3000

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3060

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattaggtaa   3120

gtgagagttt cctgcttagt cacaggagcg aatctggagc tcatgaggct gactcttcta   3180

aaatgcagcc acaggtagtc atcgaatccg gcttcctatg ctgtgcaatc aacaaatcaa   3240

aataacttgt gtcatcatta gaatgtcaga tgtgcttcta cgaactaagc tgactctttt   3300

aattctttgg caaagggttg gcaaactagg actgtttgcc aaattcaggc tgcctcctat   3360

ttttagagtc ttcctgaaac acagctacac ccgtattatc catggctgct ttcctgtcac   3420

agtgagtaag tagctgggac tgagaaggca tggcctccaa agtctaaaat atttactctc   3480

tagcactttg tagaaaaacc ttagctaggc acagtggcta acgcctgtaa tcccagcatt   3540

ttgggaggcc aaggcaggca gatcacctga ggtcaggagt tccagaccag cctggccaac   3600

atggtgaaat cccatctcta caaaaataaa acagttagct gggcatgatg gcgggtgcct   3660

gtaatcccag ctactcggga ggctgaggca ggatagtcgc ttgaacccag gaggtggagg   3720

ttgcaatgag ccaagatcat gccactgcac tccagcctgg acgacagagt gagactccat   3780

cacaagaaaa aaagaacttt gtcaacctct gtcttagggc gccttgtcac aggcttcggg   3840

tcagacggat tcaaccttgc atcagccatt tgttagccag gtcactctgt tctttgtctg   3900

taaatgagat tgatcgttgt tcccactgag agtgtcagct ccttcccgta gagcaggcat   3960

gatgattgta ctcacctctg acaccattgt gagtgccaca ttccttccca cgtccttgtc   4020

actgtaagag atgcccacct gagcaccaac cccaggttat cttccccttt gtcttccagc   4080

cccccagaaa cagctacgac tcaacctacc caatcatttc atcatcagat tgccactgtc   4140

tctagttcag gtctcttggg actggcactc agaaatctca taataaatcc tcttgaggct   4200

tctcatacac tcgtcttctt ccaatcttct ttccctcaaa atctcatatt ttggttccac   4260

ttcacccacc gtcattctcc atatcactcc caggagttag gcaaaaagcc ccttccgttc   4320

ttccgtatgt taaacttaga atcactctgt tccctgctct gcgtttctat tttttgtttt   4380

tcctccattt actagtagct taacactttc taacagtgtt cttattattg atacgtatct   4440

atctcttcca taagcttata aggtcacgga taatacttct cattgtagta cgtaaatgac   4500

gtgggctaga tatgagttga ataaacagtt atacctgtaa attcttacag agtgaaaata   4560

aattgttata ctttacaatt tgtttctctc tttagaccat ttccaggact tgtgattaat   4620

aaccgtgagt attttgtgaa gtgttttgtt tttgtttttt cctggggtct gacgtgtgtg   4680

cgtgtgagtg tgtatacatg cttaacgtat atcacgttac ttcacctatg tcagtaacca   4740

ggccaaatac ttgttttagc cctcagtaaa aacaccaggc acttcctagt tgtaaaatta   4800

ttcaagcttc ttaacttcct atcctcgatg cacttaatca taaaatggta ataatagcac   4860

cgattttggg ggagtcgttc cagtagatgg aaagcatctg gaacaggtgt cagcaagctc   4920

ctgccgacgt gtatgcataa agttttattg aaaccaccat cgtgtccatt tgtttatggc   4980

agaactgaga gatggcagca gcaagtgtgt gcctgcaaaa cctaaaatat ttactaattg   5040

gctctgcaag aaaagagttt gcatccccct aacctagaac agtgtctagc ctctagtatg   5100

tgtttagcct acagtatgtg ctcagcgaat acaatctata tttattactg cttttatgac   5160

tgttataatt actgtgcttg gatttcgtta caaagtaagt cacaatgtgc ctgcttctgt   5220

tagtatttca gcacagtgcc tggcacacat ggggctctca aatattgctg agcgagtgaa   5280

caaatgtcct ttcaattcct taacgttgat gtcattttca atagtatttt gagccaaact   5340

taattttgcg agtgtgtttt gttttcttaa ctttattatt aaaaatgtat aaaagtgagg   5400

ccaggcgtgg tggctcacgc ctgtaatccc agcagtttgg gaggctgagg caggcggatc   5460

agttgaggtt gggagttgga gaccagcccg tccaacatgg tgaaagcctg tctctactaa   5520

aaatacaaaa atcagctggg tgtggtggcg cgtgcctgta atcccagcta ctcaggaggc   5580

tgaggcagga gagttgcttg aatcctagag gtggaggttg cagtgagctg agatcgtgcc   5640

attgcactcc agcctgggca acaagagcaa aactctgtcc caataaataa ataaataaaa   5700

tgttctcttt tgttcctgtt cttgtgcggt agtgtggtat agagttttat ggtaattact   5760

gtgaattagt gattctgagg gacatatcag aactctgagg tttgtttcct tctcatcttg   5820

agggaaacag caaatgtatg ttaaaatgct tttccaaggg aacaacacat ccttacatta   5880

tttaaaccaa tctgcttcat tttcagagct ggttgatcag agtgagtcag aaggccccgt   5940

gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag aaataaaaga   6000

gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga cctcttccct   6060

cctagggtaa atcagcttct gtgtcaggga tgctgtgtgg tgtccatctg aaccccctgc   6120

atacgcgtag ctaatgtgat ctccccactt tcacataaga tggtggccct gccttcaggg   6180

aatgtgggag ccaggtggga gccttcccgg atatttaagc tagaagattc tacagggaga   6240

ttctccttgg atcaatatat gtctctcagt caaagatgta aaagcacttt tgccttaaaa   6300

agaatgttct gtttctaaat agagtcaacg ttgtcctcct cattggaatt cactatgagt   6360

cagaatcatt agactgactt ttttttttcc atagtaatag tattttgcag agtctcacag   6420

agctgcagat cttttgttca tcttgcagag ttaacaagtc tgatcctgtt agtccagatt   6480

tcttaaattt ggccaagtta taataggagc agtagcttga gacccgaagt caggaaactt   6540

tgacaatgga tttttttttt taatccagag acttgtactg gaatttgcct taccctgtca   6600

gctcatggac ttaaggtttc atcccgcttt atgagtgctt ctgaatccaa gtcattgtta   6660

cctgaatttg caaattaagt tgtgatattc gtgactgtta aattcctgta attagattaa   6720

cctctttgct tgcttgtttg ttttctctcc tattttagct taaagtatca gtggttgaga   6780

agagcttttc ggacctgtta ctaccccaag ctgtgtaata tacttgtata acagaaatac   6840

cttctataca aacctttttt tctactttta gatagaaatg tctacttttt cagcagttct   6900

gtgaattaaa gagcagagtg actgtgggtc tggaatggct ggtgtacttg ggaatgtact   6960

atcaggattt tacagcaatg ctgggaaatg acagggaaaa tgacaggaat gaatctcacc   7020

agatttttta tgtactcagc agagccttga gttacggtgt ttattttcca atcaagtgaa   7080

gatatctcct acttctccta ctggaacatc tcagcttctg cagtgaagaa aaattcctgt   7140

gatagttcag ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa tgatcctttg   7200

ttcacggctc tccttaatga ctgagtgaac agttcctatc tgtatatttg actaaacctt   7260

ttcctaagct atctctcatg gttcctatgt ttttttatca taattaaaag caaaaccatc   7320

tggatcacct aacagtcaga ggtcagtatc tcagcgtgtg aattatagag gaaatacaga   7380

gagaacctct tccactttta cttttcgtcc aaataaaatg catggtgtac cagaagttga   7440

agatcgggtt gaggattggg gctagctcga tgacactaag gccccaacat cgcgggacct   7500

gctgtggcgc ggattcttag gaacgctgtt ctagccggcc ccctctccag gggtcgccgt   7560

ggccggcatt atttcctagt tcttcttgta accctgaggt gccagcgcgg ggagtgagga   7620

ggggtcaggg ggctaaggat gcaacctctg acgttctgcg ccttcctagg agagtcttac   7680

atgtgttgag atttcacaag caatgcgagt tgtaaaatac cagctctaca agaagctagg   7740

ctctgtgacg gcatagtttt cagtagcttt atcacaatat tcacaatgga gaattatatg   7800

acatggtagc agaaataggc ccttttatgt gttgcttcta ttttacctca aattgtagat   7860

atagggtaat caataaaatc catccatgcc tttcacacac taagt                   7905


<210>  4709
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  4709

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
                565                 570                 575


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly 
            580                 585                 590


Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600


<210>  4710
<211>  4287
<212>  DNA
<213>  Homo sapiens

<400>  4710
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2100

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2160

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2220

tgaatcaaac ccggagttct tgaaaggatc gtccgcggga gtaataaaat caagttcgtt   2280

gttaaaaaac ctgaactagt tatttcctac ttgcctcctg ggatggctag taaaataaac   2340

actaaagctt tgcagtcccc caaaagacca cgaagtcctg ggagtaattc aaaggttcct   2400

gaaattgagg tcaccgtgga aggccctaat aacaacaatc ctcaaacctc agctgttcga   2460

accccgaccc agactaacgg ttctaacgtt cccttcaagc cacgagggag agagttttcc   2520

tttgaggcct ggaatgccaa aatcacggac ctaaaacaga aagttgaaaa tctcttcaat   2580

gagaaatgtg gggaagctct tggccttaaa caagctgtga aggtgccgtt cgcgttattt   2640

gagtctttcc cggaagactt ttatgtggaa ggcttacctg agggtgtgcc attccgaaga   2700

ccatcgactt ttggcattcc gaggctggag aagatactca gaaacaaagc caaaattaag   2760

ttcatcatta aaaagcccga aatgtttgag acggcgatta aggagagcac ctcctctaag   2820

agccctccca gaaaaataaa ttcatcaccc aatgttaata ctactgcatc aggtgttgaa   2880

gaccttaaca tcattcaggt gacaattcca gatgatgata atgaaagact ctcgaaagtt   2940

gaaaaagcta gacagctaag agaacaagtg aatgacctct ttagtcggaa atttggtgaa   3000

gctattggta tgggttttcc tgtgaaagtt ccctacagga aaatcacaat taaccctggc   3060

tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca aagcccccag ctacctggaa   3120

atcagctcca tgagaaggat cttagactct gccgagttta tcaaattcac ggtcattaga   3180

ccatttccag gacttgtgat taataaccag ctggttgatc agagtgagtc agaaggcccc   3240

gtgatacaag aatcagctga accaagccag ttggaagttc cagccacaga agaaataaaa   3300

gagactgatg gaagctctca gatcaagcaa gaaccagacc ccacgtggta gacctcttcc   3360

ctcctaggct taaagtatca gtggttgaga agagcttttc ggacctgtta ctaccccaag   3420

ctgtagcctt gagttacggt gtttattttc caatcaagtg aagatatctc ctacttctcc   3480

tactggaaca tctcagcttc tgcagtgaag aaaaattcct gtgatagttc agttctttag   3540

tttttctatt tgaaaaaaaa aaatcattta aatgatcctt tgttcacggc tctccttaat   3600

gactgagtga acagttccta tctgtatatt tgactaaacc ttttcctaag ctatctctca   3660

tggttcctat gtttttttat cataattaaa agcaaaacca tctggatcac ctaacagtca   3720

gaggtcagta tctcagcgtg tgaattatag aggaaataca gagagaacct cttccacttt   3780

tacttttcgt ccaaataaaa tgcatggtgt accagaagtt gaagatcggg ttgaggattg   3840

gggctagctc gatgacacta aggccccaac atcgcgggac ctgctgtggc gcggattctt   3900

aggaacgctg ttctagccgg ccccctctcc aggggtcgcc gtggccggca ttatttccta   3960

gttcttcttg taaccctgag gtgccagcgc ggggagtgag gaggggtcag ggggctaagg   4020

atgcaacctc tgacgttctg cgccttccta ggagagtctt acatgtgttg agatttcaca   4080

agcaatgcga gttgtaaaat accagctcta caagaagcta ggctctgtga cggcatagtt   4140

ttcagtagct ttatcacaat attcacaatg gagaattata tgacatggta gcagaaatag   4200

gcccttttat gtgttgcttc tattttacct caaattgtag atatagggta atcaataaaa   4260

tccatccatg cctttcacac actaagt                                       4287


<210>  4711
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  4711

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys 
        595                 600                 605


Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu 
    610                 615                 620


Asn 
625


<210>  4712
<211>  4491
<212>  DNA
<213>  Homo sapiens

<400>  4712
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1920

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct tagatttgtt   1980

gacagcggtt tcctggagtg ctgtcttgag aacgattctg aggaggctca gcaagaaaga   2040

gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa ctcaagctct tggactcacc   2100

gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc cggagttctt gtatgtggaa   2160

ggcttgccag aggggattcc cttccgaagc cctacctggt ttggaattcc acgacttgaa   2220

aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta aaaaacctga actagttatt   2280

tcctacttgc ctcctgggat ggctagtaaa ataaacacta aagctttgca gtcccccaaa   2340

agaccacgaa gtcctgggag taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc   2400

cctaataaca acaatcctca aacctcagct gttcgaaccc cgacccagac taacggttct   2460

aacgttccct tcaagccacg agggagagag ttttcctttg aggcctggaa tgccaaaatc   2520

acggacctaa aacagaaagt tgaaaatctc ttcaatgaga aatgtgggga agctcttggc   2580

cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt ctttcccgga agacttttat   2640

gtggaaggct tacctgaggg tgtgccattc cgaagaccat cgacttttgg cattccgagg   2700

ctggagaaga tactcagaaa caaagccaaa attaagttca tcattaaaaa gcccgaaatg   2760

tttgagacgg cgattaagga gagcacctcc tctaagagcc ctcccagaaa aataaattca   2820

tcacccaatg ttaatactac tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca   2880

attccagatg atgataatga aagactctcg aaagttgaaa aagctagaca gctaagagaa   2940

caagtgaatg acctctttag tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg   3000

aaagttccct acaggaaaat cacaattaac cctggctgtg tggtggttga tggcatgccc   3060

ccgggggtgt ccttcaaagc ccccagctac ctggaaatca gctccatgag aaggatctta   3120

gactctgccg agtttatcaa attcacggtc attagaccat ttccaggact tgtgattaat   3180

aaccagctgg ttgatcagag tgagtcagaa ggccccgtga tacaagaatc agctgaacca   3240

agccagttgg aagttccagc cacagaagaa ataaaagaga ctgatggaag ctctcagatc   3300

aagcaagaac cagaccccac gtggtagacc tcttccctcc taggcttaaa gtatcagtgg   3360

ttgagaagag cttttcggac ctgttactac cccaagctgt gtaatatact tgtataacag   3420

aaataccttc tatacaaacc tttttttcta cttttagata gaaatgtcta ctttttcagc   3480

agttctgtga attaaagagc agagtgactg tgggtctgga atggctggtg tacttgggaa   3540

tgtactatca ggattttaca gcaatgctgg gaaatgacag ggaaaatgac aggaatgaat   3600

ctcaccagat tttttatgta ctcagcagag ccttgagtta cggtgtttat tttccaatca   3660

agtgaagata tctcctactt ctcctactgg aacatctcag cttctgcagt gaagaaaaat   3720

tcctgtgata gttcagttct ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat   3780

cctttgttca cggctctcct taatgactga gtgaacagtt cctatctgta tatttgacta   3840

aaccttttcc taagctatct ctcatggttc ctatgttttt ttatcataat taaaagcaaa   3900

accatctgga tcacctaaca gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa   3960

tacagagaga acctcttcca cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga   4020

agttgaagat cgggttgagg attggggcta gctcgatgac actaaggccc caacatcgcg   4080

ggacctgctg tggcgcggat tcttaggaac gctgttctag ccggccccct ctccaggggt   4140

cgccgtggcc ggcattattt cctagttctt cttgtaaccc tgaggtgcca gcgcggggag   4200

tgaggagggg tcagggggct aaggatgcaa cctctgacgt tctgcgcctt cctaggagag   4260

tcttacatgt gttgagattt cacaagcaat gcgagttgta aaataccagc tctacaagaa   4320

gctaggctct gtgacggcat agttttcagt agctttatca caatattcac aatggagaat   4380

tatatgacat ggtagcagaa ataggccctt ttatgtgttg cttctatttt acctcaaatt   4440

gtagatatag ggtaatcaat aaaatccatc catgcctttc acacactaag t            4491


<210>  4713
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  4713

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
            500                 505                 510


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
        515                 520


<210>  4714
<211>  3950
<212>  DNA
<213>  Homo sapiens

<400>  4714
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   2040

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2100

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2160

tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg tttggaattc   2220

cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg   2280

aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc   2340

agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca   2400

ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga   2460

ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga   2520

atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg   2580

aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg   2640

aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg   2700

gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa   2760

agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa   2820

aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca   2880

ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac   2940

agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg   3000

gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg   3060

atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga   3120

gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca tttccaggac   3180

ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat   3240

cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa   3300

gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc ctaggcaaaa   3360

ccatctggat cacctaacag tcagaggtca gtatctcagc gtgtgaatta tagaggaaat   3420

acagagagaa cctcttccac ttttactttt cgtccaaata aaatgcatgg tgtaccagaa   3480

gttgaagatc gggttgagga ttggggctag ctcgatgaca ctaaggcccc aacatcgcgg   3540

gacctgctgt ggcgcggatt cttaggaacg ctgttctagc cggccccctc tccaggggtc   3600

gccgtggccg gcattatttc ctagttcttc ttgtaaccct gaggtgccag cgcggggagt   3660

gaggaggggt cagggggcta aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt   3720

cttacatgtg ttgagatttc acaagcaatg cgagttgtaa aataccagct ctacaagaag   3780

ctaggctctg tgacggcata gttttcagta gctttatcac aatattcaca atggagaatt   3840

atatgacatg gtagcagaaa taggcccttt tatgtgttgc ttctatttta cctcaaattg   3900

tagatatagg gtaatcaata aaatccatcc atgcctttca cacactaagt              3950


<210>  4715
<211>  978
<212>  PRT
<213>  Homo sapiens

<400>  4715

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu 
            580                 585                 590


Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg 
        595                 600                 605


Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys 
    610                 615                 620


Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys 
625                 630                 635                 640


Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly 
                645                 650                 655


Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn 
            660                 665                 670


Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn 
        675                 680                 685


Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu 
    690                 695                 700


Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu 
705                 710                 715                 720


Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys 
                725                 730                 735


Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu 
            740                 745                 750


Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile 
        755                 760                 765


Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile 
    770                 775                 780


Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser 
785                 790                 795                 800


Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr 
                805                 810                 815


Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro 
            820                 825                 830


Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu 
        835                 840                 845


Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile 
    850                 855                 860


Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn 
865                 870                 875                 880


Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys 
                885                 890                 895


Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser 
            900                 905                 910


Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val 
        915                 920                 925


Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile 
    930                 935                 940


Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu 
945                 950                 955                 960


Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro 
                965                 970                 975


Thr Trp 



<210>  4716
<211>  8035
<212>  DNA
<213>  Homo sapiens

<400>  4716
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2100

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2160

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2220

tgaatcaaac ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag   2280

ccctacctgg tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa   2340

gttcgttgtt aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa   2400

aataaacact aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa   2460

ggttcctgaa attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc   2520

tgttcgaacc ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga   2580

gttttccttt gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct   2640

cttcaatgag aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc   2700

gttatttgag tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt   2760

ccgaagacca tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa   2820

aattaagttc atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc   2880

ctctaagagc cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg   2940

tgttgaagac cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc   3000

gaaagttgaa aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt   3060

tggtgaagct attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa   3120

ccctggctgt gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta   3180

cctggaaatc agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt   3240

cattaggtaa gtgagagttt cctgcttagt cacaggagcg aatctggagc tcatgaggct   3300

gactcttcta aaatgcagcc acaggtagtc atcgaatccg gcttcctatg ctgtgcaatc   3360

aacaaatcaa aataacttgt gtcatcatta gaatgtcaga tgtgcttcta cgaactaagc   3420

tgactctttt aattctttgg caaagggttg gcaaactagg actgtttgcc aaattcaggc   3480

tgcctcctat ttttagagtc ttcctgaaac acagctacac ccgtattatc catggctgct   3540

ttcctgtcac agtgagtaag tagctgggac tgagaaggca tggcctccaa agtctaaaat   3600

atttactctc tagcactttg tagaaaaacc ttagctaggc acagtggcta acgcctgtaa   3660

tcccagcatt ttgggaggcc aaggcaggca gatcacctga ggtcaggagt tccagaccag   3720

cctggccaac atggtgaaat cccatctcta caaaaataaa acagttagct gggcatgatg   3780

gcgggtgcct gtaatcccag ctactcggga ggctgaggca ggatagtcgc ttgaacccag   3840

gaggtggagg ttgcaatgag ccaagatcat gccactgcac tccagcctgg acgacagagt   3900

gagactccat cacaagaaaa aaagaacttt gtcaacctct gtcttagggc gccttgtcac   3960

aggcttcggg tcagacggat tcaaccttgc atcagccatt tgttagccag gtcactctgt   4020

tctttgtctg taaatgagat tgatcgttgt tcccactgag agtgtcagct ccttcccgta   4080

gagcaggcat gatgattgta ctcacctctg acaccattgt gagtgccaca ttccttccca   4140

cgtccttgtc actgtaagag atgcccacct gagcaccaac cccaggttat cttccccttt   4200

gtcttccagc cccccagaaa cagctacgac tcaacctacc caatcatttc atcatcagat   4260

tgccactgtc tctagttcag gtctcttggg actggcactc agaaatctca taataaatcc   4320

tcttgaggct tctcatacac tcgtcttctt ccaatcttct ttccctcaaa atctcatatt   4380

ttggttccac ttcacccacc gtcattctcc atatcactcc caggagttag gcaaaaagcc   4440

ccttccgttc ttccgtatgt taaacttaga atcactctgt tccctgctct gcgtttctat   4500

tttttgtttt tcctccattt actagtagct taacactttc taacagtgtt cttattattg   4560

atacgtatct atctcttcca taagcttata aggtcacgga taatacttct cattgtagta   4620

cgtaaatgac gtgggctaga tatgagttga ataaacagtt atacctgtaa attcttacag   4680

agtgaaaata aattgttata ctttacaatt tgtttctctc tttagaccat ttccaggact   4740

tgtgattaat aaccgtgagt attttgtgaa gtgttttgtt tttgtttttt cctggggtct   4800

gacgtgtgtg cgtgtgagtg tgtatacatg cttaacgtat atcacgttac ttcacctatg   4860

tcagtaacca ggccaaatac ttgttttagc cctcagtaaa aacaccaggc acttcctagt   4920

tgtaaaatta ttcaagcttc ttaacttcct atcctcgatg cacttaatca taaaatggta   4980

ataatagcac cgattttggg ggagtcgttc cagtagatgg aaagcatctg gaacaggtgt   5040

cagcaagctc ctgccgacgt gtatgcataa agttttattg aaaccaccat cgtgtccatt   5100

tgtttatggc agaactgaga gatggcagca gcaagtgtgt gcctgcaaaa cctaaaatat   5160

ttactaattg gctctgcaag aaaagagttt gcatccccct aacctagaac agtgtctagc   5220

ctctagtatg tgtttagcct acagtatgtg ctcagcgaat acaatctata tttattactg   5280

cttttatgac tgttataatt actgtgcttg gatttcgtta caaagtaagt cacaatgtgc   5340

ctgcttctgt tagtatttca gcacagtgcc tggcacacat ggggctctca aatattgctg   5400

agcgagtgaa caaatgtcct ttcaattcct taacgttgat gtcattttca atagtatttt   5460

gagccaaact taattttgcg agtgtgtttt gttttcttaa ctttattatt aaaaatgtat   5520

aaaagtgagg ccaggcgtgg tggctcacgc ctgtaatccc agcagtttgg gaggctgagg   5580

caggcggatc agttgaggtt gggagttgga gaccagcccg tccaacatgg tgaaagcctg   5640

tctctactaa aaatacaaaa atcagctggg tgtggtggcg cgtgcctgta atcccagcta   5700

ctcaggaggc tgaggcagga gagttgcttg aatcctagag gtggaggttg cagtgagctg   5760

agatcgtgcc attgcactcc agcctgggca acaagagcaa aactctgtcc caataaataa   5820

ataaataaaa tgttctcttt tgttcctgtt cttgtgcggt agtgtggtat agagttttat   5880

ggtaattact gtgaattagt gattctgagg gacatatcag aactctgagg tttgtttcct   5940

tctcatcttg agggaaacag caaatgtatg ttaaaatgct tttccaaggg aacaacacat   6000

ccttacatta tttaaaccaa tctgcttcat tttcagagct ggttgatcag agtgagtcag   6060

aaggccccgt gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag   6120

aaataaaaga gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga   6180

cctcttccct cctagggtaa atcagcttct gtgtcaggga tgctgtgtgg tgtccatctg   6240

aaccccctgc atacgcgtag ctaatgtgat ctccccactt tcacataaga tggtggccct   6300

gccttcaggg aatgtgggag ccaggtggga gccttcccgg atatttaagc tagaagattc   6360

tacagggaga ttctccttgg atcaatatat gtctctcagt caaagatgta aaagcacttt   6420

tgccttaaaa agaatgttct gtttctaaat agagtcaacg ttgtcctcct cattggaatt   6480

cactatgagt cagaatcatt agactgactt ttttttttcc atagtaatag tattttgcag   6540

agtctcacag agctgcagat cttttgttca tcttgcagag ttaacaagtc tgatcctgtt   6600

agtccagatt tcttaaattt ggccaagtta taataggagc agtagcttga gacccgaagt   6660

caggaaactt tgacaatgga tttttttttt taatccagag acttgtactg gaatttgcct   6720

taccctgtca gctcatggac ttaaggtttc atcccgcttt atgagtgctt ctgaatccaa   6780

gtcattgtta cctgaatttg caaattaagt tgtgatattc gtgactgtta aattcctgta   6840

attagattaa cctctttgct tgcttgtttg ttttctctcc tattttagct taaagtatca   6900

gtggttgaga agagcttttc ggacctgtta ctaccccaag ctgtgtaata tacttgtata   6960

acagaaatac cttctataca aacctttttt tctactttta gatagaaatg tctacttttt   7020

cagcagttct gtgaattaaa gagcagagtg actgtgggtc tggaatggct ggtgtacttg   7080

ggaatgtact atcaggattt tacagcaatg ctgggaaatg acagggaaaa tgacaggaat   7140

gaatctcacc agatttttta tgtactcagc agagccttga gttacggtgt ttattttcca   7200

atcaagtgaa gatatctcct acttctccta ctggaacatc tcagcttctg cagtgaagaa   7260

aaattcctgt gatagttcag ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa   7320

tgatcctttg ttcacggctc tccttaatga ctgagtgaac agttcctatc tgtatatttg   7380

actaaacctt ttcctaagct atctctcatg gttcctatgt ttttttatca taattaaaag   7440

caaaaccatc tggatcacct aacagtcaga ggtcagtatc tcagcgtgtg aattatagag   7500

gaaatacaga gagaacctct tccactttta cttttcgtcc aaataaaatg catggtgtac   7560

cagaagttga agatcgggtt gaggattggg gctagctcga tgacactaag gccccaacat   7620

cgcgggacct gctgtggcgc ggattcttag gaacgctgtt ctagccggcc ccctctccag   7680

gggtcgccgt ggccggcatt atttcctagt tcttcttgta accctgaggt gccagcgcgg   7740

ggagtgagga ggggtcaggg ggctaaggat gcaacctctg acgttctgcg ccttcctagg   7800

agagtcttac atgtgttgag atttcacaag caatgcgagt tgtaaaatac cagctctaca   7860

agaagctagg ctctgtgacg gcatagtttt cagtagcttt atcacaatat tcacaatgga   7920

gaattatatg acatggtagc agaaataggc ccttttatgt gttgcttcta ttttacctca   7980

aattgtagat atagggtaat caataaaatc catccatgcc tttcacacac taagt        8035


<210>  4717
<211>  942
<212>  PRT
<213>  Homo sapiens

<400>  4717

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr 
        595                 600                 605


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe 
    610                 615                 620


Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys 
625                 630                 635                 640


Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly 
                645                 650                 655


Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro 
            660                 665                 670


Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val 
        675                 680                 685


Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro 
    690                 695                 700


Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu 
705                 710                 715                 720


Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys 
                725                 730                 735


Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys 
            740                 745                 750


Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp 
        755                 760                 765


Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser 
    770                 775                 780


Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys 
785                 790                 795                 800


Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys 
                805                 810                 815


Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro 
            820                 825                 830


Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln 
        835                 840                 845


Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys 
    850                 855                 860


Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe 
865                 870                 875                 880


Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys 
                885                 890                 895


Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly 
            900                 905                 910


Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg 
        915                 920                 925


Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
    930                 935                 940


<210>  4718
<211>  4142
<212>  DNA
<213>  Homo sapiens

<400>  4718
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2100

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2160

tttgaaattt gcttagattt gttgacagcg gtttcctgga gtgctgtctt gagaacgatt   2220

ctgaggaggc tcagcaagaa agagtgtttc agttgattgg gtgtgtctgt catggagaag   2280

gaactcaagc tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa   2340

acccggagtt cttgtatgtg gaaggcttgc cagaggggat tcccttccga agccctacct   2400

ggtttggaat tccacgactt gaaaggatcg tccgcgggag taataaaatc aagttcgttg   2460

ttaaaaaacc tgaactagtt atttcctact tgcctcctgg gatggctagt aaaataaaca   2520

ctaaagcttt gcagtccccc aaaagaccac gaagtcctgg gagtaattca aaggttcctg   2580

aaattgaggt caccgtggaa ggccctaata acaacaatcc tcaaacctca gctgttcgaa   2640

ccccgaccca gactaacggt tctaacgttc ccttcaagcc acgagggaga gagttttcct   2700

ttgaggcctg gaatgccaaa atcacggacc taaaacagaa agttgaaaat ctcttcaatg   2760

agaaatgtgg ggaagctctt ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg   2820

agtctttccc ggaagacttt tatgtggaag gcttacctga gggtgtgcca ttccgaagac   2880

catcgacttt tggcattccg aggctggaga agatactcag aaacaaagcc aaaattaagt   2940

tcatcattaa aaagcccgaa atgtttgaga cggcgattaa ggagagcacc tcctctaaga   3000

gccctcccag aaaaataaat tcatcaccca atgttaatac tactgcatca ggtgttgaag   3060

accttaacat cattcaggtg acaattccag atgatgataa tgaaagactc tcgaaagttg   3120

aaaaagctag acagctaaga gaacaagtga atgacctctt tagtcggaaa tttggtgaag   3180

ctattggtat gggttttcct gtgaaagttc cctacaggaa aatcacaatt aaccctggct   3240

gtgtggtggt tgatggcatg cccccggggg tgtccttcaa agcccccagc tacctggaaa   3300

tcagctccat gagaaggatc ttagactctg ccgagtttat caaattcacg gtcattagac   3360

catttccagg acttgtgatt aataaccagc tggttgatca gagtgagtca gaaggccccg   3420

tgatacaaga atcagctgaa ccaagccagt tggaagttcc agccacagaa gaaataaaag   3480

agactgatgg aagctctcag atcaagcaag aaccagaccc cacgtggtag acctcttccc   3540

tcctaggcaa aaccatctgg atcacctaac agtcagaggt cagtatctca gcgtgtgaat   3600

tatagaggaa atacagagag aacctcttcc acttttactt ttcgtccaaa taaaatgcat   3660

ggtgtaccag aagttgaaga tcgggttgag gattggggct agctcgatga cactaaggcc   3720

ccaacatcgc gggacctgct gtggcgcgga ttcttaggaa cgctgttcta gccggccccc   3780

tctccagggg tcgccgtggc cggcattatt tcctagttct tcttgtaacc ctgaggtgcc   3840

agcgcgggga gtgaggaggg gtcagggggc taaggatgca acctctgacg ttctgcgcct   3900

tcctaggaga gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt aaaataccag   3960

ctctacaaga agctaggctc tgtgacggca tagttttcag tagctttatc acaatattca   4020

caatggagaa ttatatgaca tggtagcaga aataggccct tttatgtgtt gcttctattt   4080

tacctcaaat tgtagatata gggtaatcaa taaaatccat ccatgccttt cacacactaa   4140

gt                                                                  4142


<210>  4719
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  4719

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala 
            580


<210>  4720
<211>  4088
<212>  DNA
<213>  Homo sapiens

<400>  4720
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1980

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   2040

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttga   2100

aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg aactagttat   2160

ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc agtcccccaa   2220

aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg   2280

ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga ctaacggttc   2340

taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga atgccaaaat   2400

cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg   2460

ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg aagactttta   2520

tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg gcattccgag   2580

gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa agcccgaaat   2640

gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa aaataaattc   2700

atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca ttcaggtgac   2760

aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac agctaagaga   2820

acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg gttttcctgt   2880

gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg atggcatgcc   2940

cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga gaaggatctt   3000

agactctgcc gagtttatca aattcacggt cattagacca tttccaggac ttgtgattaa   3060

taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat cagctgaacc   3120

aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa gctctcagat   3180

caagcaagaa ccagacccca cgtggtagac ctcttccctc ctaggagcct tgagttacgg   3240

tgtttatttt ccaatcaagt gaagatatct cctacttctc ctactggaac atctcagctt   3300

ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa   3360

aaaatcattt aaatgatcct ttgttcacgg ctctccttaa tgactgagtg aacagttcct   3420

atctgtatat ttgactaaac cttttcctaa gctatctctc atggttccta tgttttttta   3480

tcataattaa aagcaaaacc atctggatca cctaacagtc agaggtcagt atctcagcgt   3540

gtgaattata gaggaaatac agagagaacc tcttccactt ttacttttcg tccaaataaa   3600

atgcatggtg taccagaagt tgaagatcgg gttgaggatt ggggctagct cgatgacact   3660

aaggccccaa catcgcggga cctgctgtgg cgcggattct taggaacgct gttctagccg   3720

gccccctctc caggggtcgc cgtggccggc attatttcct agttcttctt gtaaccctga   3780

ggtgccagcg cggggagtga ggaggggtca gggggctaag gatgcaacct ctgacgttct   3840

gcgccttcct aggagagtct tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa   3900

taccagctct acaagaagct aggctctgtg acggcatagt tttcagtagc tttatcacaa   3960

tattcacaat ggagaattat atgacatggt agcagaaata ggccctttta tgtgttgctt   4020

ctattttacc tcaaattgta gatatagggt aatcaataaa atccatccat gcctttcaca   4080

cactaagt                                                            4088


<210>  4721
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  4721

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
                565                 570                 575


Ser Ser Leu Leu Lys Asn Leu Asn 
            580


<210>  4722
<211>  7972
<212>  DNA
<213>  Homo sapiens

<400>  4722
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   2040

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2100

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2160

atcaaacccg gagttcttgt atgtggaagg cttgccagag gggattccct tccgaagccc   2220

tacctggttt ggaattccac gacttgaaag gatcgtccgc gggagtaata aaatcaagtt   2280

cgttgttaaa aaacctgaac tagttatttc ctacttgcct cctgggatgg ctagtaaaat   2340

aaacactaaa gctttgcagt cccccaaaag accacgaagt cctgggagta attcaaaggt   2400

tcctgaaatt gaggtcaccg tggaaggccc taataacaac aatcctcaaa cctcagctgt   2460

tcgaaccccg acccagacta acggttctaa cgttcccttc aagccacgag ggagagagtt   2520

ttcctttgag gcctggaatg ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt   2580

caatgagaaa tgtggggaag ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt   2640

atttgagtct ttcccggaag acttttatgt ggaaggctta cctgagggtg tgccattccg   2700

aagaccatcg acttttggca ttccgaggct ggagaagata ctcagaaaca aagccaaaat   2760

taagttcatc attaaaaagc ccgaaatgtt tgagacggcg attaaggaga gcacctcctc   2820

taagagccct cccagaaaaa taaattcatc acccaatgtt aatactactg catcaggtgt   2880

tgaagacctt aacatcattc aggtgacaat tccagatgat gataatgaaa gactctcgaa   2940

agttgaaaaa gctagacagc taagagaaca agtgaatgac ctctttagtc ggaaatttgg   3000

tgaagctatt ggtatgggtt ttcctgtgaa agttccctac aggaaaatca caattaaccc   3060

tggctgtgtg gtggttgatg gcatgccccc gggggtgtcc ttcaaagccc ccagctacct   3120

ggaaatcagc tccatgagaa ggatcttaga ctctgccgag tttatcaaat tcacggtcat   3180

taggtaagtg agagtttcct gcttagtcac aggagcgaat ctggagctca tgaggctgac   3240

tcttctaaaa tgcagccaca ggtagtcatc gaatccggct tcctatgctg tgcaatcaac   3300

aaatcaaaat aacttgtgtc atcattagaa tgtcagatgt gcttctacga actaagctga   3360

ctcttttaat tctttggcaa agggttggca aactaggact gtttgccaaa ttcaggctgc   3420

ctcctatttt tagagtcttc ctgaaacaca gctacacccg tattatccat ggctgctttc   3480

ctgtcacagt gagtaagtag ctgggactga gaaggcatgg cctccaaagt ctaaaatatt   3540

tactctctag cactttgtag aaaaacctta gctaggcaca gtggctaacg cctgtaatcc   3600

cagcattttg ggaggccaag gcaggcagat cacctgaggt caggagttcc agaccagcct   3660

ggccaacatg gtgaaatccc atctctacaa aaataaaaca gttagctggg catgatggcg   3720

ggtgcctgta atcccagcta ctcgggaggc tgaggcagga tagtcgcttg aacccaggag   3780

gtggaggttg caatgagcca agatcatgcc actgcactcc agcctggacg acagagtgag   3840

actccatcac aagaaaaaaa gaactttgtc aacctctgtc ttagggcgcc ttgtcacagg   3900

cttcgggtca gacggattca accttgcatc agccatttgt tagccaggtc actctgttct   3960

ttgtctgtaa atgagattga tcgttgttcc cactgagagt gtcagctcct tcccgtagag   4020

caggcatgat gattgtactc acctctgaca ccattgtgag tgccacattc cttcccacgt   4080

ccttgtcact gtaagagatg cccacctgag caccaacccc aggttatctt cccctttgtc   4140

ttccagcccc ccagaaacag ctacgactca acctacccaa tcatttcatc atcagattgc   4200

cactgtctct agttcaggtc tcttgggact ggcactcaga aatctcataa taaatcctct   4260

tgaggcttct catacactcg tcttcttcca atcttctttc cctcaaaatc tcatattttg   4320

gttccacttc acccaccgtc attctccata tcactcccag gagttaggca aaaagcccct   4380

tccgttcttc cgtatgttaa acttagaatc actctgttcc ctgctctgcg tttctatttt   4440

ttgtttttcc tccatttact agtagcttaa cactttctaa cagtgttctt attattgata   4500

cgtatctatc tcttccataa gcttataagg tcacggataa tacttctcat tgtagtacgt   4560

aaatgacgtg ggctagatat gagttgaata aacagttata cctgtaaatt cttacagagt   4620

gaaaataaat tgttatactt tacaatttgt ttctctcttt agaccatttc caggacttgt   4680

gattaataac cgtgagtatt ttgtgaagtg ttttgttttt gttttttcct ggggtctgac   4740

gtgtgtgcgt gtgagtgtgt atacatgctt aacgtatatc acgttacttc acctatgtca   4800

gtaaccaggc caaatacttg ttttagccct cagtaaaaac accaggcact tcctagttgt   4860

aaaattattc aagcttctta acttcctatc ctcgatgcac ttaatcataa aatggtaata   4920

atagcaccga ttttggggga gtcgttccag tagatggaaa gcatctggaa caggtgtcag   4980

caagctcctg ccgacgtgta tgcataaagt tttattgaaa ccaccatcgt gtccatttgt   5040

ttatggcaga actgagagat ggcagcagca agtgtgtgcc tgcaaaacct aaaatattta   5100

ctaattggct ctgcaagaaa agagtttgca tccccctaac ctagaacagt gtctagcctc   5160

tagtatgtgt ttagcctaca gtatgtgctc agcgaataca atctatattt attactgctt   5220

ttatgactgt tataattact gtgcttggat ttcgttacaa agtaagtcac aatgtgcctg   5280

cttctgttag tatttcagca cagtgcctgg cacacatggg gctctcaaat attgctgagc   5340

gagtgaacaa atgtcctttc aattccttaa cgttgatgtc attttcaata gtattttgag   5400

ccaaacttaa ttttgcgagt gtgttttgtt ttcttaactt tattattaaa aatgtataaa   5460

agtgaggcca ggcgtggtgg ctcacgcctg taatcccagc agtttgggag gctgaggcag   5520

gcggatcagt tgaggttggg agttggagac cagcccgtcc aacatggtga aagcctgtct   5580

ctactaaaaa tacaaaaatc agctgggtgt ggtggcgcgt gcctgtaatc ccagctactc   5640

aggaggctga ggcaggagag ttgcttgaat cctagaggtg gaggttgcag tgagctgaga   5700

tcgtgccatt gcactccagc ctgggcaaca agagcaaaac tctgtcccaa taaataaata   5760

aataaaatgt tctcttttgt tcctgttctt gtgcggtagt gtggtataga gttttatggt   5820

aattactgtg aattagtgat tctgagggac atatcagaac tctgaggttt gtttccttct   5880

catcttgagg gaaacagcaa atgtatgtta aaatgctttt ccaagggaac aacacatcct   5940

tacattattt aaaccaatct gcttcatttt cagagctggt tgatcagagt gagtcagaag   6000

gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc acagaagaaa   6060

taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg tggtagacct   6120

cttccctcct agggtaaatc agcttctgtg tcagggatgc tgtgtggtgt ccatctgaac   6180

cccctgcata cgcgtagcta atgtgatctc cccactttca cataagatgg tggccctgcc   6240

ttcagggaat gtgggagcca ggtgggagcc ttcccggata tttaagctag aagattctac   6300

agggagattc tccttggatc aatatatgtc tctcagtcaa agatgtaaaa gcacttttgc   6360

cttaaaaaga atgttctgtt tctaaataga gtcaacgttg tcctcctcat tggaattcac   6420

tatgagtcag aatcattaga ctgacttttt tttttccata gtaatagtat tttgcagagt   6480

ctcacagagc tgcagatctt ttgttcatct tgcagagtta acaagtctga tcctgttagt   6540

ccagatttct taaatttggc caagttataa taggagcagt agcttgagac ccgaagtcag   6600

gaaactttga caatggattt ttttttttaa tccagagact tgtactggaa tttgccttac   6660

cctgtcagct catggactta aggtttcatc ccgctttatg agtgcttctg aatccaagtc   6720

attgttacct gaatttgcaa attaagttgt gatattcgtg actgttaaat tcctgtaatt   6780

agattaacct ctttgcttgc ttgtttgttt tctctcctat tttagcttaa agtatcagtg   6840

gttgagaaga gcttttcgga cctgttacta ccccaagctg tgtaatatac ttgtataaca   6900

gaaatacctt ctatacaaac ctttttttct acttttagat agaaatgtct actttttcag   6960

cagttctgtg aattaaagag cagagtgact gtgggtctgg aatggctggt gtacttggga   7020

atgtactatc aggattttac agcaatgctg ggaaatgaca gggaaaatga caggaatgaa   7080

tctcaccaga ttttttatgt actcagcaga gccttgagtt acggtgttta ttttccaatc   7140

aagtgaagat atctcctact tctcctactg gaacatctca gcttctgcag tgaagaaaaa   7200

ttcctgtgat agttcagttc tttagttttt ctatttgaaa aaaaaaaatc atttaaatga   7260

tcctttgttc acggctctcc ttaatgactg agtgaacagt tcctatctgt atatttgact   7320

aaaccttttc ctaagctatc tctcatggtt cctatgtttt tttatcataa ttaaaagcaa   7380

aaccatctgg atcacctaac agtcagaggt cagtatctca gcgtgtgaat tatagaggaa   7440

atacagagag aacctcttcc acttttactt ttcgtccaaa taaaatgcat ggtgtaccag   7500

aagttgaaga tcgggttgag gattggggct agctcgatga cactaaggcc ccaacatcgc   7560

gggacctgct gtggcgcgga ttcttaggaa cgctgttcta gccggccccc tctccagggg   7620

tcgccgtggc cggcattatt tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga   7680

gtgaggaggg gtcagggggc taaggatgca acctctgacg ttctgcgcct tcctaggaga   7740

gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt aaaataccag ctctacaaga   7800

agctaggctc tgtgacggca tagttttcag tagctttatc acaatattca caatggagaa   7860

ttatatgaca tggtagcaga aataggccct tttatgtgtt gcttctattt tacctcaaat   7920

tgtagatata gggtaatcaa taaaatccat ccatgccttt cacacactaa gt           7972


<210>  4723
<211>  921
<212>  PRT
<213>  Homo sapiens

<400>  4723

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
                565                 570                 575


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
            580                 585                 590


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
        595                 600                 605


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
    610                 615                 620


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
625                 630                 635                 640


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
                645                 650                 655


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
            660                 665                 670


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
        675                 680                 685


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
    690                 695                 700


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
705                 710                 715                 720


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
                725                 730                 735


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
            740                 745                 750


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
        755                 760                 765


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
    770                 775                 780


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
785                 790                 795                 800


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
                805                 810                 815


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
            820                 825                 830


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
        835                 840                 845


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
    850                 855                 860


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
865                 870                 875                 880


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
                885                 890                 895


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
            900                 905                 910


Glu Phe Ile Lys Phe Thr Val Ile Arg 
        915                 920


<210>  4724
<211>  5083
<212>  DNA
<213>  Homo sapiens

<400>  4724
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   1980

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2040

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2100

tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg tttggaattc   2160

cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg   2220

aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc   2280

agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca   2340

ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga   2400

ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga   2460

atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg   2520

aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg   2580

aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg   2640

gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa   2700

agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa   2760

aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca   2820

ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac   2880

agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg   2940

gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg   3000

atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga   3060

gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca tttccaggac   3120

ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat   3180

cagctgaacc aagccagttg gaagttccag ccacagaagg taaaaggacc tcttccctcc   3240

tagggtaaat cagcttctgt gtcagggatg ctgtgtggtg tccatctgaa ccccctgcat   3300

acgcgtagct aatgtgatct ccccactttc acataagatg gtggccctgc cttcagggaa   3360

tgtgggagcc aggtgggagc cttcccggat atttaagcta gaagattcta cagggagatt   3420

ctccttggat caatatatgt ctctcagtca aagatgtaaa agcacttttg ccttaaaaag   3480

aatgttctgt ttctaaatag agtcaacgtt gtcctcctca ttggaattca ctatgagtca   3540

gaatcattag actgactttt ttttttccat agtaatagta ttttgcagag tctcacagag   3600

ctgcagatct tttgttcatc ttgcagagtt aacaagtctg atcctgttag tccagatttc   3660

ttaaatttgg ccaagttata ataggagcag tagcttgaga cccgaagtca ggaaactttg   3720

acaatggatt ttttttttta atccagagac ttgtactgga atttgcctta ccctgtcagc   3780

tcatggactt aaggtttcat cccgctttat gagtgcttct gaatccaagt cattgttacc   3840

tgaatttgca aattaagttg tgatattcgt gactgttaaa ttcctgtaat tagattaacc   3900

tctttgcttg cttgtttgtt ttctctccta ttttagctta aagtatcagt ggttgagaag   3960

agcttttcgg acctgttact accccaagct gtgtaatata cttgtataac agaaatacct   4020

tctatacaaa cctttttttc tacttttaga tagaaatgtc tactttttca gcagttctgt   4080

gaattaaaga gcagagtgac tgtgggtctg gaatggctgg tgtacttggg aatgtactat   4140

caggatttta cagcaatgct gggaaatgac agggaaaatg acaggaatga atctcaccag   4200

attttttatg tactcagcag agccttgagt tacggtgttt attttccaat caagtgaaga   4260

tatctcctac ttctcctact ggaacatctc agcttctgca gtgaagaaaa attcctgtga   4320

tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat catttaaatg atcctttgtt   4380

cacggctctc cttaatgact gagtgaacag ttcctatctg tatatttgac taaacctttt   4440

cctaagctat ctctcatggt tcctatgttt ttttatcata attaaaagca aaaccatctg   4500

gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa ttatagagga aatacagaga   4560

gaacctcttc cacttttact tttcgtccaa ataaaatgca tggtgtacca gaagttgaag   4620

atcgggttga ggattggggc tagctcgatg acactaaggc cccaacatcg cgggacctgc   4680

tgtggcgcgg attcttagga acgctgttct agccggcccc ctctccaggg gtcgccgtgg   4740

ccggcattat ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg   4800

ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc ttcctaggag agtcttacat   4860

gtgttgagat ttcacaagca atgcgagttg taaaatacca gctctacaag aagctaggct   4920

ctgtgacggc atagttttca gtagctttat cacaatattc acaatggaga attatatgac   4980

atggtagcag aaataggccc ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat   5040

agggtaatca ataaaatcca tccatgcctt tcacacacta agt                     5083


<210>  4725
<211>  948
<212>  PRT
<213>  Homo sapiens

<400>  4725

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile 
        515                 520                 525


Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
545                 550                 555                 560


Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile 
                565                 570                 575


Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile 
            580                 585                 590


Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu 
        595                 600                 605


Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys 
    610                 615                 620


Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys 
625                 630                 635                 640


Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro 
                645                 650                 655


Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val 
            660                 665                 670


Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala 
        675                 680                 685


Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys 
    690                 695                 700


Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala 
705                 710                 715                 720


Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu 
                725                 730                 735


Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu 
            740                 745                 750


Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro 
        755                 760                 765


Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro 
    770                 775                 780


Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly 
785                 790                 795                 800


Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn 
                805                 810                 815


Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val 
            820                 825                 830


Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe 
        835                 840                 845


Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val 
    850                 855                 860


Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr 
865                 870                 875                 880


Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile 
                885                 890                 895


Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln 
            900                 905                 910


Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala 
        915                 920                 925


Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Gly Lys Arg Thr Ser 
    930                 935                 940


Ser Leu Leu Gly 
945


<210>  4726
<211>  4062
<212>  DNA
<213>  Homo sapiens

<400>  4726
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   2040

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gcttagattt   2100

gttgacagcg gtttcctgga gtgctgtctt gagaacgatt ctgaggaggc tcagcaagaa   2160

agagtgtttc agttgattgg gtgtgtctgt catggagaag gaactcaagc tcttggactc   2220

accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgtatgtg   2280

gaaggcttgc cagaggggat tcccttccga agccctacct ggtttggaat tccacgactt   2340

gaaaggatcg tccgcgggag taataaaatc aagttcgttg ttaaaaaacc tgaactagtt   2400

atttcctact tgcctcctgg gatggctagt aaaataaaca ctaaagcttt gcagtccccc   2460

aaaagaccac gaagtcctgg gagtaattca aaggttcctg aaattgaggt caccgtggaa   2520

ggccctaata acaacaatcc tcaaacctca gctgttcgaa ccccgaccca gactaacggt   2580

tctaacgttc ccttcaagcc acgagggaga gagttttcct ttgaggcctg gaatgccaaa   2640

atcacggacc taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg ggaagctctt   2700

ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg agtctttccc ggaagacttt   2760

tatgtggaag gcttacctga gggtgtgcca ttccgaagac catcgacttt tggcattccg   2820

aggctggaga agatactcag aaacaaagcc aaaattaagt tcatcattaa aaagcccgaa   2880

atgtttgaga cggcgattaa ggagagcacc tcctctaaga gccctcccag aaaaataaat   2940

tcatcaccca atgttaatac tactgcatca ggtgttgaag accttaacat cattcaggtg   3000

acaattccag atgatgataa tgaaagactc tcgaaagttg aaaaagctag acagctaaga   3060

gaacaagtga atgacctctt tagtcggaaa tttggtgaag ctattggtat gggttttcct   3120

gtgaaagttc cctacaggaa aatcacaatt aaccctggct gtgtggtggt tgatggcatg   3180

cccccggggg tgtccttcaa agcccccagc tacctggaaa tcagctccat gagaaggatc   3240

ttagactctg ccgagtttat caaattcacg gtcattagac catttccagg acttgtgatt   3300

aataaccagc tggttgatca gagtgagtca gaaggccccg tgatacaaga atcagctgaa   3360

ccaagccagt tggaagttcc agccacagaa gaaataaaag agactgatgg aagctctcag   3420

atcaagcaag aaccagaccc cacgtggtag acctcttccc tcctaggcaa aaccatctgg   3480

atcacctaac agtcagaggt cagtatctca gcgtgtgaat tatagaggaa atacagagag   3540

aacctcttcc acttttactt ttcgtccaaa taaaatgcat ggtgtaccag aagttgaaga   3600

tcgggttgag gattggggct agctcgatga cactaaggcc ccaacatcgc gggacctgct   3660

gtggcgcgga ttcttaggaa cgctgttcta gccggccccc tctccagggg tcgccgtggc   3720

cggcattatt tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga gtgaggaggg   3780

gtcagggggc taaggatgca acctctgacg ttctgcgcct tcctaggaga gtcttacatg   3840

tgttgagatt tcacaagcaa tgcgagttgt aaaataccag ctctacaaga agctaggctc   3900

tgtgacggca tagttttcag tagctttatc acaatattca caatggagaa ttatatgaca   3960

tggtagcaga aataggccct tttatgtgtt gcttctattt tacctcaaat tgtagatata   4020

gggtaatcaa taaaatccat ccatgccttt cacacactaa gt                      4062


<210>  4727
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  4727

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala 



<210>  4728
<211>  4355
<212>  DNA
<213>  Homo sapiens

<400>  4728
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1980

catatcctgt gtttgaatca aacccggagt tcttgtatgt ggaaggcttg ccagagggga   2040

ttcccttccg aagccctacc tggtttggaa ttccacgact tgaaaggatc gtccgcggga   2100

gtaataaaat caagttcgtt gttaaaaaac ctgaactagt tatttcctac ttgcctcctg   2160

ggatggctag taaaataaac actaaagctt tgcagtcccc caaaagacca cgaagtcctg   2220

ggagtaattc aaaggttcct gaaattgagg tcaccgtgga aggccctaat aacaacaatc   2280

ctcaaacctc agctgttcga accccgaccc agactaacgg ttctaacgtt cccttcaagc   2340

cacgagggag agagttttcc tttgaggcct ggaatgccaa aatcacggac ctaaaacaga   2400

aagttgaaaa tctcttcaat gagaaatgtg gggaagctct tggccttaaa caagctgtga   2460

aggtgccgtt cgcgttattt gagtctttcc cggaagactt ttatgtggaa ggcttacctg   2520

agggtgtgcc attccgaaga ccatcgactt ttggcattcc gaggctggag aagatactca   2580

gaaacaaagc caaaattaag ttcatcatta aaaagcccga aatgtttgag acggcgatta   2640

aggagagcac ctcctctaag agccctccca gaaaaataaa ttcatcaccc aatgttaata   2700

ctactgcatc aggtgttgaa gaccttaaca tcattcaggt gacaattcca gatgatgata   2760

atgaaagact ctcgaaagtt gaaaaagcta gacagctaag agaacaagtg aatgacctct   2820

ttagtcggaa atttggtgaa gctattggta tgggttttcc tgtgaaagtt ccctacagga   2880

aaatcacaat taaccctggc tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca   2940

aagcccccag ctacctggaa atcagctcca tgagaaggat cttagactct gccgagttta   3000

tcaaattcac ggtcattaga ccatttccag gacttgtgat taataaccag ctggttgatc   3060

agagtgagtc agaaggcccc gtgatacaag aatcagctga accaagccag ttggaagttc   3120

cagccacaga agaaataaaa gagactgatg gaagctctca gatcaagcaa gaaccagacc   3180

ccacgtggta gacctcttcc ctcctaggct taaagtatca gtggttgaga agagcttttc   3240

ggacctgtta ctaccccaag ctgtgtaata tacttgtata acagaaatac cttctataca   3300

aacctttttt tctactttta gatagaaatg tctacttttt cagcagttct gtgaattaaa   3360

gagcagagtg actgtgggtc tggaatggct ggtgtacttg ggaatgtact atcaggattt   3420

tacagcaatg ctgggaaatg acagggaaaa tgacaggaat gaatctcacc agatttttta   3480

tgtactcagc agagccttga gttacggtgt ttattttcca atcaagtgaa gatatctcct   3540

acttctccta ctggaacatc tcagcttctg cagtgaagaa aaattcctgt gatagttcag   3600

ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa tgatcctttg ttcacggctc   3660

tccttaatga ctgagtgaac agttcctatc tgtatatttg actaaacctt ttcctaagct   3720

atctctcatg gttcctatgt ttttttatca taattaaaag caaaaccatc tggatcacct   3780

aacagtcaga ggtcagtatc tcagcgtgtg aattatagag gaaatacaga gagaacctct   3840

tccactttta cttttcgtcc aaataaaatg catggtgtac cagaagttga agatcgggtt   3900

gaggattggg gctagctcga tgacactaag gccccaacat cgcgggacct gctgtggcgc   3960

ggattcttag gaacgctgtt ctagccggcc ccctctccag gggtcgccgt ggccggcatt   4020

atttcctagt tcttcttgta accctgaggt gccagcgcgg ggagtgagga ggggtcaggg   4080

ggctaaggat gcaacctctg acgttctgcg ccttcctagg agagtcttac atgtgttgag   4140

atttcacaag caatgcgagt tgtaaaatac cagctctaca agaagctagg ctctgtgacg   4200

gcatagtttt cagtagcttt atcacaatat tcacaatgga gaattatatg acatggtagc   4260

agaaataggc ccttttatgt gttgcttcta ttttacctca aattgtagat atagggtaat   4320

caataaaatc catccatgcc tttcacacac taagt                              4355


<210>  4729
<211>  868
<212>  PRT
<213>  Homo sapiens

<400>  4729

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
            420                 425                 430


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
        435                 440                 445


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
    450                 455                 460


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu 
465                 470                 475                 480


Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile 
                485                 490                 495


Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val 
            500                 505                 510


Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala 
        515                 520                 525


Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser 
    530                 535                 540


Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly 
545                 550                 555                 560


Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln 
                565                 570                 575


Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser 
            580                 585                 590


Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu 
        595                 600                 605


Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala 
    610                 615                 620


Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr 
625                 630                 635                 640


Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe 
                645                 650                 655


Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys 
            660                 665                 670


Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser 
        675                 680                 685


Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val 
    690                 695                 700


Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr 
705                 710                 715                 720


Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg 
                725                 730                 735


Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu 
            740                 745                 750


Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr 
        755                 760                 765


Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser 
    770                 775                 780


Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu 
785                 790                 795                 800


Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly 
                805                 810                 815


Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro 
            820                 825                 830


Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr 
        835                 840                 845


Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro 
    850                 855                 860


Asp Pro Thr Trp 
865


<210>  4730
<211>  4059
<212>  DNA
<213>  Homo sapiens

<400>  4730
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agctcaagct cttggactca ccgaggcagt aaaagtacca tatcctgtgt   1980

ttgaatcaaa cccggagttc ttgtatgtgg aaggcttgcc agaggggatt cccttccgaa   2040

gccctacctg gtttggaatt ccacgacttg aaaggatcgt ccgcgggagt aataaaatca   2100

agttcgttgt taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta   2160

aaataaacac taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa   2220

aggttcctga aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag   2280

ctgttcgaac cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag   2340

agttttcctt tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc   2400

tcttcaatga gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg   2460

cgttatttga gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat   2520

tccgaagacc atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca   2580

aaattaagtt catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct   2640

cctctaagag ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag   2700

gtgttgaaga ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct   2760

cgaaagttga aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat   2820

ttggtgaagc tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta   2880

accctggctg tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct   2940

acctggaaat cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg   3000

tcattagacc atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag   3060

aaggccccgt gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag   3120

aaataaaaga gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga   3180

cctcttccct cctaggagcc ttgagttacg gtgtttattt tccaatcaag tgaagatatc   3240

tcctacttct cctactggaa catctcagct tctgcagtga agaaaaattc ctgtgatagt   3300

tcagttcttt agtttttcta tttgaaaaaa aaaaatcatt taaatgatcc tttgttcacg   3360

gctctcctta atgactgagt gaacagttcc tatctgtata tttgactaaa ccttttccta   3420

agctatctct catggttcct atgttttttt atcataatta aaagcaaaac catctggatc   3480

acctaacagt cagaggtcag tatctcagcg tgtgaattat agaggaaata cagagagaac   3540

ctcttccact tttacttttc gtccaaataa aatgcatggt gtaccagaag ttgaagatcg   3600

ggttgaggat tggggctagc tcgatgacac taaggcccca acatcgcggg acctgctgtg   3660

gcgcggattc ttaggaacgc tgttctagcc ggccccctct ccaggggtcg ccgtggccgg   3720

cattatttcc tagttcttct tgtaaccctg aggtgccagc gcggggagtg aggaggggtc   3780

agggggctaa ggatgcaacc tctgacgttc tgcgccttcc taggagagtc ttacatgtgt   3840

tgagatttca caagcaatgc gagttgtaaa ataccagctc tacaagaagc taggctctgt   3900

gacggcatag ttttcagtag ctttatcaca atattcacaa tggagaatta tatgacatgg   3960

tagcagaaat aggccctttt atgtgttgct tctattttac ctcaaattgt agatataggg   4020

taatcaataa aatccatcca tgcctttcac acactaagt                          4059


<210>  4731
<211>  864
<212>  PRT
<213>  Homo sapiens

<400>  4731

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro 
    450                 455                 460


Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu 
465                 470                 475                 480


Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu 
                485                 490                 495


Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro 
            500                 505                 510


Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn 
        515                 520                 525


Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn 
    530                 535                 540


Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn 
545                 550                 555                 560


Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser 
                565                 570                 575


Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp 
            580                 585                 590


Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn 
        595                 600                 605


Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro 
    610                 615                 620


Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu 
625                 630                 635                 640


Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg 
                645                 650                 655


Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys 
            660                 665                 670


Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys 
        675                 680                 685


Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala 
    690                 695                 700


Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp 
705                 710                 715                 720


Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu 
                725                 730                 735


Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met 
            740                 745                 750


Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly 
        755                 760                 765


Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro 
    770                 775                 780


Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu 
785                 790                 795                 800


Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn 
                805                 810                 815


Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu 
            820                 825                 830


Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys 
        835                 840                 845


Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
    850                 855                 860


<210>  4732
<211>  3803
<212>  DNA
<213>  Homo sapiens

<400>  4732
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1980

catatcctgt gtttgaatca aacccggagt tcttgtatgt ggaaggcttg ccagagggga   2040

ttcccttccg aagccctacc tggtttggaa ttccacgact tgaaaggatc gtccgcggga   2100

gtaataaaat caagttcgtt gttaaaaaac ctgaactagt tatttcctac ttgcctcctg   2160

ggatggctag taaaataaac actaaagctt tgcagtcccc caaaagacca cgaagtcctg   2220

ggagtaattc aaaggttcct gaaattgagg tcaccgtgga aggccctaat aacaacaatc   2280

ctcaaacctc agctgttcga accccgaccc agactaacgg ttctaacgtt cccttcaagc   2340

cacgagggag agagttttcc tttgaggcct ggaatgccaa aatcacggac ctaaaacaga   2400

aagttgaaaa tctcttcaat gagaaatgtg gggaagctct tggccttaaa caagctgtga   2460

aggtgccgtt cgcgttattt gagtctttcc cggaagactt ttatgtggaa ggcttacctg   2520

agggtgtgcc attccgaaga ccatcgactt ttggcattcc gaggctggag aagatactca   2580

gaaacaaagc caaaattaag ttcatcatta aaaagcccga aatgtttgag acggcgatta   2640

aggagagcac ctcctctaag agccctccca gaaaaataaa ttcatcaccc aatgttaata   2700

ctactgcatc aggtgttgaa gaccttaaca tcattcaggt gacaattcca gatgatgata   2760

atgaaagact ctcgaaagtt gaaaaagcta gacagctaag agaacaagtg aatgacctct   2820

ttagtcggaa atttggtgaa gctattggta tgggttttcc tgtgaaagtt ccctacagga   2880

aaatcacaat taaccctggc tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca   2940

aagcccccag ctacctggaa atcagctcca tgagaaggat cttagactct gccgagttta   3000

tcaaattcac ggtcattaga ccatttccag gacttgtgat taataaccag ctggttgatc   3060

agagtgagtc agaaggcccc gtgatacaag aatcagctga accaagccag ttggaagttc   3120

cagccacaga agaaataaaa gagactgatg gaagctctca gatcaagcaa gaaccagacc   3180

ccacgtggta gacctcttcc ctcctaggca aaaccatctg gatcacctaa cagtcagagg   3240

tcagtatctc agcgtgtgaa ttatagagga aatacagaga gaacctcttc cacttttact   3300

tttcgtccaa ataaaatgca tggtgtacca gaagttgaag atcgggttga ggattggggc   3360

tagctcgatg acactaaggc cccaacatcg cgggacctgc tgtggcgcgg attcttagga   3420

acgctgttct agccggcccc ctctccaggg gtcgccgtgg ccggcattat ttcctagttc   3480

ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc   3540

aacctctgac gttctgcgcc ttcctaggag agtcttacat gtgttgagat ttcacaagca   3600

atgcgagttg taaaatacca gctctacaag aagctaggct ctgtgacggc atagttttca   3660

gtagctttat cacaatattc acaatggaga attatatgac atggtagcag aaataggccc   3720

ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat agggtaatca ataaaatcca   3780

tccatgcctt tcacacacta agt                                           3803


<210>  4733
<211>  868
<212>  PRT
<213>  Homo sapiens

<400>  4733

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
            420                 425                 430


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
        435                 440                 445


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
    450                 455                 460


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu 
465                 470                 475                 480


Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile 
                485                 490                 495


Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val 
            500                 505                 510


Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala 
        515                 520                 525


Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser 
    530                 535                 540


Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly 
545                 550                 555                 560


Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln 
                565                 570                 575


Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser 
            580                 585                 590


Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu 
        595                 600                 605


Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala 
    610                 615                 620


Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr 
625                 630                 635                 640


Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe 
                645                 650                 655


Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys 
            660                 665                 670


Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser 
        675                 680                 685


Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val 
    690                 695                 700


Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr 
705                 710                 715                 720


Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg 
                725                 730                 735


Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu 
            740                 745                 750


Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr 
        755                 760                 765


Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser 
    770                 775                 780


Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu 
785                 790                 795                 800


Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly 
                805                 810                 815


Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro 
            820                 825                 830


Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr 
        835                 840                 845


Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro 
    850                 855                 860


Asp Pro Thr Trp 
865


<210>  4734
<211>  5151
<212>  DNA
<213>  Homo sapiens

<400>  4734
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   1980

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2040

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2100

atcaaacccg gagttcttgt atgtggaagg cttgccagag gggattccct tccgaagccc   2160

tacctggttt ggaattccac gacttgaaag gatcgtccgc gggagtaata aaatcaagtt   2220

cgttgttaaa aaacctgaac tagttatttc ctacttgcct cctgggatgg ctagtaaaat   2280

aaacactaaa gctttgcagt cccccaaaag accacgaagt cctgggagta attcaaaggt   2340

tcctgaaatt gaggtcaccg tggaaggccc taataacaac aatcctcaaa cctcagctgt   2400

tcgaaccccg acccagacta acggttctaa cgttcccttc aagccacgag ggagagagtt   2460

ttcctttgag gcctggaatg ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt   2520

caatgagaaa tgtggggaag ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt   2580

atttgagtct ttcccggaag acttttatgt ggaaggctta cctgagggtg tgccattccg   2640

aagaccatcg acttttggca ttccgaggct ggagaagata ctcagaaaca aagccaaaat   2700

taagttcatc attaaaaagc ccgaaatgtt tgagacggcg attaaggaga gcacctcctc   2760

taagagccct cccagaaaaa taaattcatc acccaatgtt aatactactg catcaggtgt   2820

tgaagacctt aacatcattc aggtgacaat tccagatgat gataatgaaa gactctcgaa   2880

agttgaaaaa gctagacagc taagagaaca agtgaatgac ctctttagtc ggaaatttgg   2940

tgaagctatt ggtatgggtt ttcctgtgaa agttccctac aggaaaatca caattaaccc   3000

tggctgtgtg gtggttgatg gcatgccccc gggggtgtcc ttcaaagccc ccagctacct   3060

ggaaatcagc tccatgagaa ggatcttaga ctctgccgag tttatcaaat tcacggtcat   3120

tagaccattt ccaggacttg tgattaataa ccagctggtt gatcagagtg agtcagaagg   3180

ccccgtgata caagaatcag ctgaaccaag ccagttggaa gttccagcca cagaagaaat   3240

aaaagagact gatggaagct ctcagatcaa gcaagaacca gaccccacgt ggtagacctc   3300

ttccctccta gggtaaatca gcttctgtgt cagggatgct gtgtggtgtc catctgaacc   3360

ccctgcatac gcgtagctaa tgtgatctcc ccactttcac ataagatggt ggccctgcct   3420

tcagggaatg tgggagccag gtgggagcct tcccggatat ttaagctaga agattctaca   3480

gggagattct ccttggatca atatatgtct ctcagtcaaa gatgtaaaag cacttttgcc   3540

ttaaaaagaa tgttctgttt ctaaatagag tcaacgttgt cctcctcatt ggaattcact   3600

atgagtcaga atcattagac tgactttttt ttttccatag taatagtatt ttgcagagtc   3660

tcacagagct gcagatcttt tgttcatctt gcagagttaa caagtctgat cctgttagtc   3720

cagatttctt aaatttggcc aagttataat aggagcagta gcttgagacc cgaagtcagg   3780

aaactttgac aatggatttt tttttttaat ccagagactt gtactggaat ttgccttacc   3840

ctgtcagctc atggacttaa ggtttcatcc cgctttatga gtgcttctga atccaagtca   3900

ttgttacctg aatttgcaaa ttaagttgtg atattcgtga ctgttaaatt cctgtaatta   3960

gattaacctc tttgcttgct tgtttgtttt ctctcctatt ttagcttaaa gtatcagtgg   4020

ttgagaagag cttttcggac ctgttactac cccaagctgt gtaatatact tgtataacag   4080

aaataccttc tatacaaacc tttttttcta cttttagata gaaatgtcta ctttttcagc   4140

agttctgtga attaaagagc agagtgactg tgggtctgga atggctggtg tacttgggaa   4200

tgtactatca ggattttaca gcaatgctgg gaaatgacag ggaaaatgac aggaatgaat   4260

ctcaccagat tttttatgta ctcagcagag ccttgagtta cggtgtttat tttccaatca   4320

agtgaagata tctcctactt ctcctactgg aacatctcag cttctgcagt gaagaaaaat   4380

tcctgtgata gttcagttct ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat   4440

cctttgttca cggctctcct taatgactga gtgaacagtt cctatctgta tatttgacta   4500

aaccttttcc taagctatct ctcatggttc ctatgttttt ttatcataat taaaagcaaa   4560

accatctgga tcacctaaca gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa   4620

tacagagaga acctcttcca cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga   4680

agttgaagat cgggttgagg attggggcta gctcgatgac actaaggccc caacatcgcg   4740

ggacctgctg tggcgcggat tcttaggaac gctgttctag ccggccccct ctccaggggt   4800

cgccgtggcc ggcattattt cctagttctt cttgtaaccc tgaggtgcca gcgcggggag   4860

tgaggagggg tcagggggct aaggatgcaa cctctgacgt tctgcgcctt cctaggagag   4920

tcttacatgt gttgagattt cacaagcaat gcgagttgta aaataccagc tctacaagaa   4980

gctaggctct gtgacggcat agttttcagt agctttatca caatattcac aatggagaat   5040

tatatgacat ggtagcagaa ataggccctt ttatgtgttg cttctatttt acctcaaatt   5100

gtagatatag ggtaatcaat aaaatccatc catgcctttc acacactaag t            5151


<210>  4735
<211>  957
<212>  PRT
<213>  Homo sapiens

<400>  4735

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
                565                 570                 575


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
            580                 585                 590


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
        595                 600                 605


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
    610                 615                 620


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
625                 630                 635                 640


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
                645                 650                 655


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
            660                 665                 670


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
        675                 680                 685


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
    690                 695                 700


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
705                 710                 715                 720


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
                725                 730                 735


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
            740                 745                 750


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
        755                 760                 765


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
    770                 775                 780


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
785                 790                 795                 800


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
                805                 810                 815


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
            820                 825                 830


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
        835                 840                 845


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
    850                 855                 860


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
865                 870                 875                 880


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
                885                 890                 895


Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu 
            900                 905                 910


Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu 
        915                 920                 925


Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp 
    930                 935                 940


Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950                 955


<210>  4736
<211>  4323
<212>  DNA
<213>  Homo sapiens

<400>  4736
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1980

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct tagatttgtt   2040

gacagcggtt tcctggagtg ctgtcttgag aacgattctg aggaggctca gcaagaaaga   2100

gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa ctcaagctct tggactcacc   2160

gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc cggagttctt gtatgtggaa   2220

ggcttgccag aggggattcc cttccgaagc cctacctggt ttggaattcc acgacttgaa   2280

aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta aaaaacctga actagttatt   2340

tcctacttgc ctcctgggat ggctagtaaa ataaacacta aagctttgca gtcccccaaa   2400

agaccacgaa gtcctgggag taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc   2460

cctaataaca acaatcctca aacctcagct gttcgaaccc cgacccagac taacggttct   2520

aacgttccct tcaagccacg agggagagag ttttcctttg aggcctggaa tgccaaaatc   2580

acggacctaa aacagaaagt tgaaaatctc ttcaatgaga aatgtgggga agctcttggc   2640

cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt ctttcccgga agacttttat   2700

gtggaaggct tacctgaggg tgtgccattc cgaagaccat cgacttttgg cattccgagg   2760

ctggagaaga tactcagaaa caaagccaaa attaagttca tcattaaaaa gcccgaaatg   2820

tttgagacgg cgattaagga gagcacctcc tctaagagcc ctcccagaaa aataaattca   2880

tcacccaatg ttaatactac tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca   2940

attccagatg atgataatga aagactctcg aaagttgaaa aagctagaca gctaagagaa   3000

caagtgaatg acctctttag tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg   3060

aaagttccct acaggaaaat cacaattaac cctggctgtg tggtggttga tggcatgccc   3120

ccgggggtgt ccttcaaagc ccccagctac ctggaaatca gctccatgag aaggatctta   3180

gactctgccg agtttatcaa attcacggtc attagaccat ttccaggact tgtgattaat   3240

aaccagctgg ttgatcagag tgagtcagaa ggccccgtga tacaagaatc agctgaacca   3300

agccagttgg aagttccagc cacagaagaa ataaaagaga ctgatggaag ctctcagatc   3360

aagcaagaac cagaccccac gtggtagacc tcttccctcc taggcttaaa gtatcagtgg   3420

ttgagaagag cttttcggac ctgttactac cccaagctgt agccttgagt tacggtgttt   3480

attttccaat caagtgaaga tatctcctac ttctcctact ggaacatctc agcttctgca   3540

gtgaagaaaa attcctgtga tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat   3600

catttaaatg atcctttgtt cacggctctc cttaatgact gagtgaacag ttcctatctg   3660

tatatttgac taaacctttt cctaagctat ctctcatggt tcctatgttt ttttatcata   3720

attaaaagca aaaccatctg gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa   3780

ttatagagga aatacagaga gaacctcttc cacttttact tttcgtccaa ataaaatgca   3840

tggtgtacca gaagttgaag atcgggttga ggattggggc tagctcgatg acactaaggc   3900

cccaacatcg cgggacctgc tgtggcgcgg attcttagga acgctgttct agccggcccc   3960

ctctccaggg gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac cctgaggtgc   4020

cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc   4080

ttcctaggag agtcttacat gtgttgagat ttcacaagca atgcgagttg taaaatacca   4140

gctctacaag aagctaggct ctgtgacggc atagttttca gtagctttat cacaatattc   4200

acaatggaga attatatgac atggtagcag aaataggccc ttttatgtgt tgcttctatt   4260

ttacctcaaa ttgtagatat agggtaatca ataaaatcca tccatgcctt tcacacacta   4320

agt                                                                 4323


<210>  4737
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  4737

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  4738
<211>  4551
<212>  DNA
<213>  Homo sapiens

<400>  4738
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1980

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct tagatttgtt   2040

gacagcggtt tcctggagtg ctgtcttgag aacgattctg aggaggctca gcaagaaaga   2100

gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa ctcaagctct tggactcacc   2160

gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc cggagttctt gtatgtggaa   2220

ggcttgccag aggggattcc cttccgaagc cctacctggt ttggaattcc acgacttgaa   2280

aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta aaaaacctga actagttatt   2340

tcctacttgc ctcctgggat ggctagtaaa ataaacacta aagctttgca gtcccccaaa   2400

agaccacgaa gtcctgggag taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc   2460

cctaataaca acaatcctca aacctcagct gttcgaaccc cgacccagac taacggttct   2520

aacgttccct tcaagccacg agggagagag ttttcctttg aggcctggaa tgccaaaatc   2580

acggacctaa aacagaaagt tgaaaatctc ttcaatgaga aatgtgggga agctcttggc   2640

cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt ctttcccgga agacttttat   2700

gtggaaggct tacctgaggg tgtgccattc cgaagaccat cgacttttgg cattccgagg   2760

ctggagaaga tactcagaaa caaagccaaa attaagttca tcattaaaaa gcccgaaatg   2820

tttgagacgg cgattaagga gagcacctcc tctaagagcc ctcccagaaa aataaattca   2880

tcacccaatg ttaatactac tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca   2940

attccagatg atgataatga aagactctcg aaagttgaaa aagctagaca gctaagagaa   3000

caagtgaatg acctctttag tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg   3060

aaagttccct acaggaaaat cacaattaac cctggctgtg tggtggttga tggcatgccc   3120

ccgggggtgt ccttcaaagc ccccagctac ctggaaatca gctccatgag aaggatctta   3180

gactctgccg agtttatcaa attcacggtc attagaccat ttccaggact tgtgattaat   3240

aaccagctgg ttgatcagag tgagtcagaa ggccccgtga tacaagaatc agctgaacca   3300

agccagttgg aagttccagc cacagaagaa ataaaagaga ctgatggaag ctctcagatc   3360

aagcaagaac cagaccccac gtggtagacc tcttccctcc taggcttaaa gtatcagtgg   3420

ttgagaagag cttttcggac ctgttactac cccaagctgt gtaatatact tgtataacag   3480

aaataccttc tatacaaacc tttttttcta cttttagata gaaatgtcta ctttttcagc   3540

agttctgtga attaaagagc agagtgactg tgggtctgga atggctggtg tacttgggaa   3600

tgtactatca ggattttaca gcaatgctgg gaaatgacag ggaaaatgac aggaatgaat   3660

ctcaccagat tttttatgta ctcagcagag ccttgagtta cggtgtttat tttccaatca   3720

agtgaagata tctcctactt ctcctactgg aacatctcag cttctgcagt gaagaaaaat   3780

tcctgtgata gttcagttct ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat   3840

cctttgttca cggctctcct taatgactga gtgaacagtt cctatctgta tatttgacta   3900

aaccttttcc taagctatct ctcatggttc ctatgttttt ttatcataat taaaagcaaa   3960

accatctgga tcacctaaca gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa   4020

tacagagaga acctcttcca cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga   4080

agttgaagat cgggttgagg attggggcta gctcgatgac actaaggccc caacatcgcg   4140

ggacctgctg tggcgcggat tcttaggaac gctgttctag ccggccccct ctccaggggt   4200

cgccgtggcc ggcattattt cctagttctt cttgtaaccc tgaggtgcca gcgcggggag   4260

tgaggagggg tcagggggct aaggatgcaa cctctgacgt tctgcgcctt cctaggagag   4320

tcttacatgt gttgagattt cacaagcaat gcgagttgta aaataccagc tctacaagaa   4380

gctaggctct gtgacggcat agttttcagt agctttatca caatattcac aatggagaat   4440

tatatgacat ggtagcagaa ataggccctt ttatgtgttg cttctatttt acctcaaatt   4500

gtagatatag ggtaatcaat aaaatccatc catgcctttc acacactaag t            4551


<210>  4739
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  4739

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  4740
<211>  5144
<212>  DNA
<213>  Homo sapiens

<400>  4740
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1860

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1920

tgaaatttgc ttagatttgt tgacagcggt ttcctggagt gctgtcttga gaacgattct   1980

gaggaggctc agcaagaaag agtgtttcag ttgattgggt gtgtctgtca tggagaagga   2040

actcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac   2100

ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg   2160

tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2220

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2280

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2340

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2400

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2460

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2520

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2580

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2640

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2700

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2760

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2820

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2880

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2940

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   3000

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3060

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca   3120

tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg   3180

atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag   3240

actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc   3300

ctagggtaaa tcagcttctg tgtcagggat gctgtgtggt gtccatctga accccctgca   3360

tacgcgtagc taatgtgatc tccccacttt cacataagat ggtggccctg ccttcaggga   3420

atgtgggagc caggtgggag ccttcccgga tatttaagct agaagattct acagggagat   3480

tctccttgga tcaatatatg tctctcagtc aaagatgtaa aagcactttt gccttaaaaa   3540

gaatgttctg tttctaaata gagtcaacgt tgtcctcctc attggaattc actatgagtc   3600

agaatcatta gactgacttt tttttttcca tagtaatagt attttgcaga gtctcacaga   3660

gctgcagatc ttttgttcat cttgcagagt taacaagtct gatcctgtta gtccagattt   3720

cttaaatttg gccaagttat aataggagca gtagcttgag acccgaagtc aggaaacttt   3780

gacaatggat tttttttttt aatccagaga cttgtactgg aatttgcctt accctgtcag   3840

ctcatggact taaggtttca tcccgcttta tgagtgcttc tgaatccaag tcattgttac   3900

ctgaatttgc aaattaagtt gtgatattcg tgactgttaa attcctgtaa ttagattaac   3960

ctctttgctt gcttgtttgt tttctctcct attttagctt aaagtatcag tggttgagaa   4020

gagcttttcg gacctgttac taccccaagc tgtgtaatat acttgtataa cagaaatacc   4080

ttctatacaa accttttttt ctacttttag atagaaatgt ctactttttc agcagttctg   4140

tgaattaaag agcagagtga ctgtgggtct ggaatggctg gtgtacttgg gaatgtacta   4200

tcaggatttt acagcaatgc tgggaaatga cagggaaaat gacaggaatg aatctcacca   4260

gattttttat gtactcagca gagccttgag ttacggtgtt tattttccaa tcaagtgaag   4320

atatctccta cttctcctac tggaacatct cagcttctgc agtgaagaaa aattcctgtg   4380

atagttcagt tctttagttt ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt   4440

tcacggctct ccttaatgac tgagtgaaca gttcctatct gtatatttga ctaaaccttt   4500

tcctaagcta tctctcatgg ttcctatgtt tttttatcat aattaaaagc aaaaccatct   4560

ggatcaccta acagtcagag gtcagtatct cagcgtgtga attatagagg aaatacagag   4620

agaacctctt ccacttttac ttttcgtcca aataaaatgc atggtgtacc agaagttgaa   4680

gatcgggttg aggattgggg ctagctcgat gacactaagg ccccaacatc gcgggacctg   4740

ctgtggcgcg gattcttagg aacgctgttc tagccggccc cctctccagg ggtcgccgtg   4800

gccggcatta tttcctagtt cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag   4860

gggtcagggg gctaaggatg caacctctga cgttctgcgc cttcctagga gagtcttaca   4920

tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc agctctacaa gaagctaggc   4980

tctgtgacgg catagttttc agtagcttta tcacaatatt cacaatggag aattatatga   5040

catggtagca gaaataggcc cttttatgtg ttgcttctat tttacctcaa attgtagata   5100

tagggtaatc aataaaatcc atccatgcct ttcacacact aagt                    5144


<210>  4741
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  4741

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg 
            420                 425                 430


Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe 
        435                 440                 445


Ala 



<210>  4742
<211>  5151
<212>  DNA
<213>  Homo sapiens

<400>  4742
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagc   2100

tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc   2160

ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc ctacctggtt   2220

tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa   2280

aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa taaacactaa   2340

agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg ttcctgaaat   2400

tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg ttcgaacccc   2460

gacccagact aacggttcta acgttccctt caagccacga gggagagagt tttcctttga   2520

ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct tcaatgagaa   2580

atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc   2640

tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc gaagaccatc   2700

gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa ttaagttcat   2760

cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct ctaagagccc   2820

tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg ttgaagacct   2880

taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga aagttgaaaa   2940

agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg gtgaagctat   3000

tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc ctggctgtgt   3060

ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc tggaaatcag   3120

ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca ttagaccatt   3180

tccaggactt gtgattaata accagctggt tgatcagagt gagtcagaag gccccgtgat   3240

acaagaatca gctgaaccaa gccagttgga agttccagcc acagaaggta aaaggacctc   3300

ttccctccta gggtaaatca gcttctgtgt cagggatgct gtgtggtgtc catctgaacc   3360

ccctgcatac gcgtagctaa tgtgatctcc ccactttcac ataagatggt ggccctgcct   3420

tcagggaatg tgggagccag gtgggagcct tcccggatat ttaagctaga agattctaca   3480

gggagattct ccttggatca atatatgtct ctcagtcaaa gatgtaaaag cacttttgcc   3540

ttaaaaagaa tgttctgttt ctaaatagag tcaacgttgt cctcctcatt ggaattcact   3600

atgagtcaga atcattagac tgactttttt ttttccatag taatagtatt ttgcagagtc   3660

tcacagagct gcagatcttt tgttcatctt gcagagttaa caagtctgat cctgttagtc   3720

cagatttctt aaatttggcc aagttataat aggagcagta gcttgagacc cgaagtcagg   3780

aaactttgac aatggatttt tttttttaat ccagagactt gtactggaat ttgccttacc   3840

ctgtcagctc atggacttaa ggtttcatcc cgctttatga gtgcttctga atccaagtca   3900

ttgttacctg aatttgcaaa ttaagttgtg atattcgtga ctgttaaatt cctgtaatta   3960

gattaacctc tttgcttgct tgtttgtttt ctctcctatt ttagcttaaa gtatcagtgg   4020

ttgagaagag cttttcggac ctgttactac cccaagctgt gtaatatact tgtataacag   4080

aaataccttc tatacaaacc tttttttcta cttttagata gaaatgtcta ctttttcagc   4140

agttctgtga attaaagagc agagtgactg tgggtctgga atggctggtg tacttgggaa   4200

tgtactatca ggattttaca gcaatgctgg gaaatgacag ggaaaatgac aggaatgaat   4260

ctcaccagat tttttatgta ctcagcagag ccttgagtta cggtgtttat tttccaatca   4320

agtgaagata tctcctactt ctcctactgg aacatctcag cttctgcagt gaagaaaaat   4380

tcctgtgata gttcagttct ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat   4440

cctttgttca cggctctcct taatgactga gtgaacagtt cctatctgta tatttgacta   4500

aaccttttcc taagctatct ctcatggttc ctatgttttt ttatcataat taaaagcaaa   4560

accatctgga tcacctaaca gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa   4620

tacagagaga acctcttcca cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga   4680

agttgaagat cgggttgagg attggggcta gctcgatgac actaaggccc caacatcgcg   4740

ggacctgctg tggcgcggat tcttaggaac gctgttctag ccggccccct ctccaggggt   4800

cgccgtggcc ggcattattt cctagttctt cttgtaaccc tgaggtgcca gcgcggggag   4860

tgaggagggg tcagggggct aaggatgcaa cctctgacgt tctgcgcctt cctaggagag   4920

tcttacatgt gttgagattt cacaagcaat gcgagttgta aaataccagc tctacaagaa   4980

gctaggctct gtgacggcat agttttcagt agctttatca caatattcac aatggagaat   5040

tatatgacat ggtagcagaa ataggccctt ttatgtgttg cttctatttt acctcaaatt   5100

gtagatatag ggtaatcaat aaaatccatc catgcctttc acacactaag t            5151


<210>  4743
<211>  964
<212>  PRT
<213>  Homo sapiens

<400>  4743

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala 
545                 550                 555                 560


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
                565                 570                 575


Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile 
            580                 585                 590


Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile 
        595                 600                 605


Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu 
    610                 615                 620


Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys 
625                 630                 635                 640


Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys 
                645                 650                 655


Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro 
            660                 665                 670


Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val 
        675                 680                 685


Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala 
    690                 695                 700


Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys 
705                 710                 715                 720


Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala 
                725                 730                 735


Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu 
            740                 745                 750


Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu 
        755                 760                 765


Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro 
    770                 775                 780


Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro 
785                 790                 795                 800


Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly 
                805                 810                 815


Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn 
            820                 825                 830


Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val 
        835                 840                 845


Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe 
    850                 855                 860


Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val 
865                 870                 875                 880


Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr 
                885                 890                 895


Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile 
            900                 905                 910


Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln 
        915                 920                 925


Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala 
    930                 935                 940


Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Gly Lys Arg Thr Ser 
945                 950                 955                 960


Ser Leu Leu Gly 



<210>  4744
<211>  4127
<212>  DNA
<213>  Homo sapiens

<400>  4744
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1980

catatcctgt gtttgaatca aacccggagt tcttgtatgt ggaaggcttg ccagagggga   2040

ttcccttccg aagccctacc tggtttggaa ttccacgact tgaaaggatc gtccgcggga   2100

gtaataaaat caagttcgtt gttaaaaaac ctgaactagt tatttcctac ttgcctcctg   2160

ggatggctag taaaataaac actaaagctt tgcagtcccc caaaagacca cgaagtcctg   2220

ggagtaattc aaaggttcct gaaattgagg tcaccgtgga aggccctaat aacaacaatc   2280

ctcaaacctc agctgttcga accccgaccc agactaacgg ttctaacgtt cccttcaagc   2340

cacgagggag agagttttcc tttgaggcct ggaatgccaa aatcacggac ctaaaacaga   2400

aagttgaaaa tctcttcaat gagaaatgtg gggaagctct tggccttaaa caagctgtga   2460

aggtgccgtt cgcgttattt gagtctttcc cggaagactt ttatgtggaa ggcttacctg   2520

agggtgtgcc attccgaaga ccatcgactt ttggcattcc gaggctggag aagatactca   2580

gaaacaaagc caaaattaag ttcatcatta aaaagcccga aatgtttgag acggcgatta   2640

aggagagcac ctcctctaag agccctccca gaaaaataaa ttcatcaccc aatgttaata   2700

ctactgcatc aggtgttgaa gaccttaaca tcattcaggt gacaattcca gatgatgata   2760

atgaaagact ctcgaaagtt gaaaaagcta gacagctaag agaacaagtg aatgacctct   2820

ttagtcggaa atttggtgaa gctattggta tgggttttcc tgtgaaagtt ccctacagga   2880

aaatcacaat taaccctggc tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca   2940

aagcccccag ctacctggaa atcagctcca tgagaaggat cttagactct gccgagttta   3000

tcaaattcac ggtcattaga ccatttccag gacttgtgat taataaccag ctggttgatc   3060

agagtgagtc agaaggcccc gtgatacaag aatcagctga accaagccag ttggaagttc   3120

cagccacaga agaaataaaa gagactgatg gaagctctca gatcaagcaa gaaccagacc   3180

ccacgtggta gacctcttcc ctcctaggct taaagtatca gtggttgaga agagcttttc   3240

ggacctgtta ctaccccaag ctgtagcctt gagttacggt gtttattttc caatcaagtg   3300

aagatatctc ctacttctcc tactggaaca tctcagcttc tgcagtgaag aaaaattcct   3360

gtgatagttc agttctttag tttttctatt tgaaaaaaaa aaatcattta aatgatcctt   3420

tgttcacggc tctccttaat gactgagtga acagttccta tctgtatatt tgactaaacc   3480

ttttcctaag ctatctctca tggttcctat gtttttttat cataattaaa agcaaaacca   3540

tctggatcac ctaacagtca gaggtcagta tctcagcgtg tgaattatag aggaaataca   3600

gagagaacct cttccacttt tacttttcgt ccaaataaaa tgcatggtgt accagaagtt   3660

gaagatcggg ttgaggattg gggctagctc gatgacacta aggccccaac atcgcgggac   3720

ctgctgtggc gcggattctt aggaacgctg ttctagccgg ccccctctcc aggggtcgcc   3780

gtggccggca ttatttccta gttcttcttg taaccctgag gtgccagcgc ggggagtgag   3840

gaggggtcag ggggctaagg atgcaacctc tgacgttctg cgccttccta ggagagtctt   3900

acatgtgttg agatttcaca agcaatgcga gttgtaaaat accagctcta caagaagcta   3960

ggctctgtga cggcatagtt ttcagtagct ttatcacaat attcacaatg gagaattata   4020

tgacatggta gcagaaatag gcccttttat gtgttgcttc tattttacct caaattgtag   4080

atatagggta atcaataaaa tccatccatg cctttcacac actaagt                 4127


<210>  4745
<211>  868
<212>  PRT
<213>  Homo sapiens

<400>  4745

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
            420                 425                 430


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
        435                 440                 445


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
    450                 455                 460


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu 
465                 470                 475                 480


Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile 
                485                 490                 495


Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val 
            500                 505                 510


Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala 
        515                 520                 525


Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser 
    530                 535                 540


Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly 
545                 550                 555                 560


Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln 
                565                 570                 575


Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser 
            580                 585                 590


Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu 
        595                 600                 605


Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala 
    610                 615                 620


Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr 
625                 630                 635                 640


Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe 
                645                 650                 655


Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys 
            660                 665                 670


Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser 
        675                 680                 685


Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val 
    690                 695                 700


Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr 
705                 710                 715                 720


Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg 
                725                 730                 735


Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu 
            740                 745                 750


Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr 
        755                 760                 765


Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser 
    770                 775                 780


Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu 
785                 790                 795                 800


Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly 
                805                 810                 815


Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro 
            820                 825                 830


Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr 
        835                 840                 845


Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro 
    850                 855                 860


Asp Pro Thr Trp 
865


<210>  4746
<211>  5047
<212>  DNA
<213>  Homo sapiens

<400>  4746
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1980

catatcctgt gtttgaatca aacccggagt tcttgtatgt ggaaggcttg ccagagggga   2040

ttcccttccg aagccctacc tggtttggaa ttccacgact tgaaaggatc gtccgcggga   2100

gtaataaaat caagttcgtt gttaaaaaac ctgaactagt tatttcctac ttgcctcctg   2160

ggatggctag taaaataaac actaaagctt tgcagtcccc caaaagacca cgaagtcctg   2220

ggagtaattc aaaggttcct gaaattgagg tcaccgtgga aggccctaat aacaacaatc   2280

ctcaaacctc agctgttcga accccgaccc agactaacgg ttctaacgtt cccttcaagc   2340

cacgagggag agagttttcc tttgaggcct ggaatgccaa aatcacggac ctaaaacaga   2400

aagttgaaaa tctcttcaat gagaaatgtg gggaagctct tggccttaaa caagctgtga   2460

aggtgccgtt cgcgttattt gagtctttcc cggaagactt ttatgtggaa ggcttacctg   2520

agggtgtgcc attccgaaga ccatcgactt ttggcattcc gaggctggag aagatactca   2580

gaaacaaagc caaaattaag ttcatcatta aaaagcccga aatgtttgag acggcgatta   2640

aggagagcac ctcctctaag agccctccca gaaaaataaa ttcatcaccc aatgttaata   2700

ctactgcatc aggtgttgaa gaccttaaca tcattcaggt gacaattcca gatgatgata   2760

atgaaagact ctcgaaagtt gaaaaagcta gacagctaag agaacaagtg aatgacctct   2820

ttagtcggaa atttggtgaa gctattggta tgggttttcc tgtgaaagtt ccctacagga   2880

aaatcacaat taaccctggc tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca   2940

aagcccccag ctacctggaa atcagctcca tgagaaggat cttagactct gccgagttta   3000

tcaaattcac ggtcattaga ccatttccag gacttgtgat taataaccag ctggttgatc   3060

agagtgagtc agaaggcccc gtgatacaag aatcagctga accaagccag ttggaagttc   3120

cagccacaga agaaataaaa gagactgatg gaagctctca gatcaagcaa gaaccagacc   3180

ccacgtggta gacctcttcc ctcctagggt aaatcagctt ctgtgtcagg gatgctgtgt   3240

ggtgtccatc tgaaccccct gcatacgcgt agctaatgtg atctccccac tttcacataa   3300

gatggtggcc ctgccttcag ggaatgtggg agccaggtgg gagccttccc ggatatttaa   3360

gctagaagat tctacaggga gattctcctt ggatcaatat atgtctctca gtcaaagatg   3420

taaaagcact tttgccttaa aaagaatgtt ctgtttctaa atagagtcaa cgttgtcctc   3480

ctcattggaa ttcactatga gtcagaatca ttagactgac tttttttttt ccatagtaat   3540

agtattttgc agagtctcac agagctgcag atcttttgtt catcttgcag agttaacaag   3600

tctgatcctg ttagtccaga tttcttaaat ttggccaagt tataatagga gcagtagctt   3660

gagacccgaa gtcaggaaac tttgacaatg gatttttttt tttaatccag agacttgtac   3720

tggaatttgc cttaccctgt cagctcatgg acttaaggtt tcatcccgct ttatgagtgc   3780

ttctgaatcc aagtcattgt tacctgaatt tgcaaattaa gttgtgatat tcgtgactgt   3840

taaattcctg taattagatt aacctctttg cttgcttgtt tgttttctct cctattttag   3900

cttaaagtat cagtggttga gaagagcttt tcggacctgt tactacccca agctgtgtaa   3960

tatacttgta taacagaaat accttctata caaacctttt tttctacttt tagatagaaa   4020

tgtctacttt ttcagcagtt ctgtgaatta aagagcagag tgactgtggg tctggaatgg   4080

ctggtgtact tgggaatgta ctatcaggat tttacagcaa tgctgggaaa tgacagggaa   4140

aatgacagga atgaatctca ccagattttt tatgtactca gcagagcctt gagttacggt   4200

gtttattttc caatcaagtg aagatatctc ctacttctcc tactggaaca tctcagcttc   4260

tgcagtgaag aaaaattcct gtgatagttc agttctttag tttttctatt tgaaaaaaaa   4320

aaatcattta aatgatcctt tgttcacggc tctccttaat gactgagtga acagttccta   4380

tctgtatatt tgactaaacc ttttcctaag ctatctctca tggttcctat gtttttttat   4440

cataattaaa agcaaaacca tctggatcac ctaacagtca gaggtcagta tctcagcgtg   4500

tgaattatag aggaaataca gagagaacct cttccacttt tacttttcgt ccaaataaaa   4560

tgcatggtgt accagaagtt gaagatcggg ttgaggattg gggctagctc gatgacacta   4620

aggccccaac atcgcgggac ctgctgtggc gcggattctt aggaacgctg ttctagccgg   4680

ccccctctcc aggggtcgcc gtggccggca ttatttccta gttcttcttg taaccctgag   4740

gtgccagcgc ggggagtgag gaggggtcag ggggctaagg atgcaacctc tgacgttctg   4800

cgccttccta ggagagtctt acatgtgttg agatttcaca agcaatgcga gttgtaaaat   4860

accagctcta caagaagcta ggctctgtga cggcatagtt ttcagtagct ttatcacaat   4920

attcacaatg gagaattata tgacatggta gcagaaatag gcccttttat gtgttgcttc   4980

tattttacct caaattgtag atatagggta atcaataaaa tccatccatg cctttcacac   5040

actaagt                                                             5047


<210>  4747
<211>  868
<212>  PRT
<213>  Homo sapiens

<400>  4747

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
            420                 425                 430


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
        435                 440                 445


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
    450                 455                 460


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu 
465                 470                 475                 480


Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile 
                485                 490                 495


Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val 
            500                 505                 510


Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala 
        515                 520                 525


Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser 
    530                 535                 540


Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly 
545                 550                 555                 560


Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln 
                565                 570                 575


Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser 
            580                 585                 590


Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu 
        595                 600                 605


Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala 
    610                 615                 620


Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr 
625                 630                 635                 640


Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe 
                645                 650                 655


Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys 
            660                 665                 670


Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser 
        675                 680                 685


Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val 
    690                 695                 700


Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr 
705                 710                 715                 720


Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg 
                725                 730                 735


Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu 
            740                 745                 750


Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr 
        755                 760                 765


Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser 
    770                 775                 780


Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu 
785                 790                 795                 800


Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly 
                805                 810                 815


Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro 
            820                 825                 830


Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr 
        835                 840                 845


Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro 
    850                 855                 860


Asp Pro Thr Trp 
865


<210>  4748
<211>  7179
<212>  DNA
<213>  Homo sapiens

<400>  4748
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040

taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2100

ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2160

ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2220

ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2280

ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2340

atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2400

agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2460

agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2520

tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2580

ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2640

tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2700

ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2760

atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2820

ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2880

tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   2940

ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   3000

tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3060

ttatcaaatt cacggtcatt aggtaagtga gagtttcctg cttagtcaca ggagcgaatc   3120

tggagctcat gaggctgact cttctaaaat gcagccacag gtagtcatcg aatccggctt   3180

cctatgctgt gcaatcaaca aatcaaaata acttgtgtca tcattagaat gtcagatgtg   3240

cttctacgaa ctaagctgac tcttttaatt ctttggcaaa gggttggcaa actaggactg   3300

tttgccaaat tcaggctgcc tcctattttt agagtcttcc tgaaacacag ctacacccgt   3360

attatccatg gctgctttcc tgtcacagtg agtaagtagc tgggactgag aaggcatggc   3420

ctccaaagtc taaaatattt actctctagc actttgtaga aaaaccttag ctaggcacag   3480

tggctaacgc ctgtaatccc agcattttgg gaggccaagg caggcagatc acctgaggtc   3540

aggagttcca gaccagcctg gccaacatgg tgaaatccca tctctacaaa aataaaacag   3600

ttagctgggc atgatggcgg gtgcctgtaa tcccagctac tcgggaggct gaggcaggat   3660

agtcgcttga acccaggagg tggaggttgc aatgagccaa gatcatgcca ctgcactcca   3720

gcctggacga cagagtgaga ctccatcaca agaaaaaaag aactttgtca acctctgtct   3780

tagggcgcct tgtcacaggc ttcgggtcag acggattcaa ccttgcatca gccatttgtt   3840

agccaggtca ctctgttctt tgtctgtaaa tgagattgat cgttgttccc actgagagtg   3900

tcagctcctt cccgtagagc aggcatgatg attgtactca cctctgacac cattgtgagt   3960

gccacattcc ttcccacgtc cttgtcactg taagagatgc ccacctgagc accaacccca   4020

ggttatcttc ccctttgtct tccagccccc cagaaacagc tacgactcaa cctacccaat   4080

catttcatca tcagattgcc actgtctcta gttcaggtct cttgggactg gcactcagaa   4140

atctcataat aaatcctctt gaggcttctc atacactcgt cttcttccaa tcttctttcc   4200

ctcaaaatct catattttgg ttccacttca cccaccgtca ttctccatat cactcccagg   4260

agttaggcaa aaagcccctt ccgttcttcc gtatgttaaa cttagaatca ctctgttccc   4320

tgctctgcgt ttctattttt tgtttttcct ccatttacta gtagcttaac actttctaac   4380

agtgttctta ttattgatac gtatctatct cttccataag cttataaggt cacggataat   4440

acttctcatt gtagtacgta aatgacgtgg gctagatatg agttgaataa acagttatac   4500

ctgtaaattc ttacagagtg aaaataaatt gttatacttt acaatttgtt tctctcttta   4560

gaccatttcc aggacttgtg attaataacc gtgagtattt tgtgaagtgt tttgtttttg   4620

ttttttcctg gggtctgacg tgtgtgcgtg tgagtgtgta tacatgctta acgtatatca   4680

cgttacttca cctatgtcag taaccaggcc aaatacttgt tttagccctc agtaaaaaca   4740

ccaggcactt cctagttgta aaattattca agcttcttaa cttcctatcc tcgatgcact   4800

taatcataaa atggtaataa tagcaccgat tttgggggag tcgttccagt agatggaaag   4860

catctggaac aggtgtcagc aagctcctgc cgacgtgtat gcataaagtt ttattgaaac   4920

caccatcgtg tccatttgtt tatggcagaa ctgagagatg gcagcagcaa gtgtgtgcct   4980

gcaaaaccta aaatatttac taattggctc tgcaagaaaa gagtttgcat ccccctaacc   5040

tagaacagtg tctagcctct agtatgtgtt tagcctacag tatgtgctca gcgaatacaa   5100

tctatattta ttactgcttt tatgactgtt ataattactg tgcttggatt tcgttacaaa   5160

gtaagtcaca atgtgcctgc ttctgttagt atttcagcac agtgcctggc acacatgggg   5220

ctctcaaata ttgctgagcg agtgaacaaa tgtcctttca attccttaac gttgatgtca   5280

ttttcaatag tattttgagc caaacttaat tttgcgagtg tgttttgttt tcttaacttt   5340

attattaaaa atgtataaaa gtgaggccag gcgtggtggc tcacgcctgt aatcccagca   5400

gtttgggagg ctgaggcagg cggatcagtt gaggttggga gttggagacc agcccgtcca   5460

acatggtgaa agcctgtctc tactaaaaat acaaaaatca gctgggtgtg gtggcgcgtg   5520

cctgtaatcc cagctactca ggaggctgag gcaggagagt tgcttgaatc ctagaggtgg   5580

aggttgcagt gagctgagat cgtgccattg cactccagcc tgggcaacaa gagcaaaact   5640

ctgtcccaat aaataaataa ataaaatgtt ctcttttgtt cctgttcttg tgcggtagtg   5700

tggtatagag ttttatggta attactgtga attagtgatt ctgagggaca tatcagaact   5760

ctgaggtttg tttccttctc atcttgaggg aaacagcaaa tgtatgttaa aatgcttttc   5820

caagggaaca acacatcctt acattattta aaccaatctg cttcattttc agagctggtt   5880

gatcagagtg agtcagaagg ccccgtgata caagaatcag ctgaaccaag ccagttggaa   5940

gttccagcca cagaagaaat aaaagagact gatggaagct ctcagatcaa gcaagaacca   6000

gaccccacgt ggtagacctc ttccctccta ggcttaaagt atcagtggtt gagaagagct   6060

tttcggacct gttactaccc caagctgtgt aatatacttg tataacagaa ataccttcta   6120

tacaaacctt tttttctact tttagataga aatgtctact ttttcagcag ttctgtgaat   6180

taaagagcag agtgactgtg ggtctggaat ggctggtgta cttgggaatg tactatcagg   6240

attttacagc aatgctggga aatgacaggg aaaatgacag gaatgaatct caccagattt   6300

tttatgtact cagcagagcc ttgagttacg gtgtttattt tccaatcaag tgaagatatc   6360

tcctacttct cctactggaa catctcagct tctgcagtga agaaaaattc ctgtgatagt   6420

tcagttcttt agtttttcta tttgaaaaaa aaaaatcatt taaatgatcc tttgttcacg   6480

gctctcctta atgactgagt gaacagttcc tatctgtata tttgactaaa ccttttccta   6540

agctatctct catggttcct atgttttttt atcataatta aaagcaaaac catctggatc   6600

acctaacagt cagaggtcag tatctcagcg tgtgaattat agaggaaata cagagagaac   6660

ctcttccact tttacttttc gtccaaataa aatgcatggt gtaccagaag ttgaagatcg   6720

ggttgaggat tggggctagc tcgatgacac taaggcccca acatcgcggg acctgctgtg   6780

gcgcggattc ttaggaacgc tgttctagcc ggccccctct ccaggggtcg ccgtggccgg   6840

cattatttcc tagttcttct tgtaaccctg aggtgccagc gcggggagtg aggaggggtc   6900

agggggctaa ggatgcaacc tctgacgttc tgcgccttcc taggagagtc ttacatgtgt   6960

tgagatttca caagcaatgc gagttgtaaa ataccagctc tacaagaagc taggctctgt   7020

gacggcatag ttttcagtag ctttatcaca atattcacaa tggagaatta tatgacatgg   7080

tagcagaaat aggccctttt atgtgttgct tctattttac ctcaaattgt agatataggg   7140

taatcaataa aatccatcca tgcctttcac acactaagt                          7179


<210>  4749
<211>  833
<212>  PRT
<213>  Homo sapiens

<400>  4749

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
    450                 455                 460


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
465                 470                 475                 480


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
                485                 490                 495


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
            500                 505                 510


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
        515                 520                 525


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
    530                 535                 540


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
545                 550                 555                 560


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
                565                 570                 575


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
            580                 585                 590


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
        595                 600                 605


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
    610                 615                 620


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
625                 630                 635                 640


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
                645                 650                 655


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
            660                 665                 670


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
        675                 680                 685


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
    690                 695                 700


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
705                 710                 715                 720


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
                725                 730                 735


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
            740                 745                 750


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
        755                 760                 765


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
    770                 775                 780


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
785                 790                 795                 800


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
                805                 810                 815


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
            820                 825                 830


Arg 



<210>  4750
<211>  4386
<212>  DNA
<213>  Homo sapiens

<400>  4750
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   2040

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gcttagattt   2100

gttgacagcg gtttcctgga gtgctgtctt gagaacgatt ctgaggaggc tcagcaagaa   2160

agagtgtttc agttgattgg gtgtgtctgt catggagaag gaactcaagc tcttggactc   2220

accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgtatgtg   2280

gaaggcttgc cagaggggat tcccttccga agccctacct ggtttggaat tccacgactt   2340

gaaaggatcg tccgcgggag taataaaatc aagttcgttg ttaaaaaacc tgaactagtt   2400

atttcctact tgcctcctgg gatggctagt aaaataaaca ctaaagcttt gcagtccccc   2460

aaaagaccac gaagtcctgg gagtaattca aaggttcctg aaattgaggt caccgtggaa   2520

ggccctaata acaacaatcc tcaaacctca gctgttcgaa ccccgaccca gactaacggt   2580

tctaacgttc ccttcaagcc acgagggaga gagttttcct ttgaggcctg gaatgccaaa   2640

atcacggacc taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg ggaagctctt   2700

ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg agtctttccc ggaagacttt   2760

tatgtggaag gcttacctga gggtgtgcca ttccgaagac catcgacttt tggcattccg   2820

aggctggaga agatactcag aaacaaagcc aaaattaagt tcatcattaa aaagcccgaa   2880

atgtttgaga cggcgattaa ggagagcacc tcctctaaga gccctcccag aaaaataaat   2940

tcatcaccca atgttaatac tactgcatca ggtgttgaag accttaacat cattcaggtg   3000

acaattccag atgatgataa tgaaagactc tcgaaagttg aaaaagctag acagctaaga   3060

gaacaagtga atgacctctt tagtcggaaa tttggtgaag ctattggtat gggttttcct   3120

gtgaaagttc cctacaggaa aatcacaatt aaccctggct gtgtggtggt tgatggcatg   3180

cccccggggg tgtccttcaa agcccccagc tacctggaaa tcagctccat gagaaggatc   3240

ttagactctg ccgagtttat caaattcacg gtcattagac catttccagg acttgtgatt   3300

aataaccagc tggttgatca gagtgagtca gaaggccccg tgatacaaga atcagctgaa   3360

ccaagccagt tggaagttcc agccacagaa gaaataaaag agactgatgg aagctctcag   3420

atcaagcaag aaccagaccc cacgtggtag acctcttccc tcctaggctt aaagtatcag   3480

tggttgagaa gagcttttcg gacctgttac taccccaagc tgtagccttg agttacggtg   3540

tttattttcc aatcaagtga agatatctcc tacttctcct actggaacat ctcagcttct   3600

gcagtgaaga aaaattcctg tgatagttca gttctttagt ttttctattt gaaaaaaaaa   3660

aatcatttaa atgatccttt gttcacggct ctccttaatg actgagtgaa cagttcctat   3720

ctgtatattt gactaaacct tttcctaagc tatctctcat ggttcctatg tttttttatc   3780

ataattaaaa gcaaaaccat ctggatcacc taacagtcag aggtcagtat ctcagcgtgt   3840

gaattataga ggaaatacag agagaacctc ttccactttt acttttcgtc caaataaaat   3900

gcatggtgta ccagaagttg aagatcgggt tgaggattgg ggctagctcg atgacactaa   3960

ggccccaaca tcgcgggacc tgctgtggcg cggattctta ggaacgctgt tctagccggc   4020

cccctctcca ggggtcgccg tggccggcat tatttcctag ttcttcttgt aaccctgagg   4080

tgccagcgcg gggagtgagg aggggtcagg gggctaagga tgcaacctct gacgttctgc   4140

gccttcctag gagagtctta catgtgttga gatttcacaa gcaatgcgag ttgtaaaata   4200

ccagctctac aagaagctag gctctgtgac ggcatagttt tcagtagctt tatcacaata   4260

ttcacaatgg agaattatat gacatggtag cagaaatagg cccttttatg tgttgcttct   4320

attttacctc aaattgtaga tatagggtaa tcaataaaat ccatccatgc ctttcacaca   4380

ctaagt                                                              4386


<210>  4751
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  4751

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala 



<210>  4752
<211>  3924
<212>  DNA
<213>  Homo sapiens

<400>  4752
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gtcaaagaag attggaatgt cagaattacc aagctacgga   1920

agcaagtgga agagattttt aatttgaaat ttgcttagat ttgttgacag cggtttcctg   1980

gagtgctgtc ttgagaacga ttctgaggag gctcagcaag aaagagtgtt tcagttgatt   2040

gggtgtgtct gtcatggaga aggaactcaa gctcttggac tcaccgaggc agtaaaagta   2100

ccatatcctg tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg   2160

attcccttcc gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg   2220

agtaataaaa tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct   2280

gggatggcta gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct   2340

gggagtaatt caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat   2400

cctcaaacct cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag   2460

ccacgaggga gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag   2520

aaagttgaaa atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg   2580

aaggtgccgt tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct   2640

gagggtgtgc cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc   2700

agaaacaaag ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt   2760

aaggagagca cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat   2820

actactgcat caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat   2880

aatgaaagac tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc   2940

tttagtcgga aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg   3000

aaaatcacaa ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc   3060

aaagccccca gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt   3120

atcaaattca cggtcattag accatttcca ggacttgtga ttaataacca gctggttgat   3180

cagagtgagt cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt   3240

ccagccacag aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac   3300

cccacgtggt agacctcttc cctcctaggc aaaaccatct ggatcaccta acagtcagag   3360

gtcagtatct cagcgtgtga attatagagg aaatacagag agaacctctt ccacttttac   3420

ttttcgtcca aataaaatgc atggtgtacc agaagttgaa gatcgggttg aggattgggg   3480

ctagctcgat gacactaagg ccccaacatc gcgggacctg ctgtggcgcg gattcttagg   3540

aacgctgttc tagccggccc cctctccagg ggtcgccgtg gccggcatta tttcctagtt   3600

cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg gctaaggatg   3660

caacctctga cgttctgcgc cttcctagga gagtcttaca tgtgttgaga tttcacaagc   3720

aatgcgagtt gtaaaatacc agctctacaa gaagctaggc tctgtgacgg catagttttc   3780

agtagcttta tcacaatatt cacaatggag aattatatga catggtagca gaaataggcc   3840

cttttatgtg ttgcttctat tttacctcaa attgtagata tagggtaatc aataaaatcc   3900

atccatgcct ttcacacact aagt                                          3924


<210>  4753
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  4753

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
                485                 490                 495


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
            500                 505                 510


Phe Asn Leu Lys Phe Ala 
        515


<210>  4754
<211>  7825
<212>  DNA
<213>  Homo sapiens

<400>  4754
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1980

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   2040

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttga   2100

aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg aactagttat   2160

ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc agtcccccaa   2220

aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg   2280

ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga ctaacggttc   2340

taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga atgccaaaat   2400

cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg   2460

ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg aagactttta   2520

tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg gcattccgag   2580

gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa agcccgaaat   2640

gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa aaataaattc   2700

atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca ttcaggtgac   2760

aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac agctaagaga   2820

acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg gttttcctgt   2880

gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg atggcatgcc   2940

cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga gaaggatctt   3000

agactctgcc gagtttatca aattcacggt cattaggtaa gtgagagttt cctgcttagt   3060

cacaggagcg aatctggagc tcatgaggct gactcttcta aaatgcagcc acaggtagtc   3120

atcgaatccg gcttcctatg ctgtgcaatc aacaaatcaa aataacttgt gtcatcatta   3180

gaatgtcaga tgtgcttcta cgaactaagc tgactctttt aattctttgg caaagggttg   3240

gcaaactagg actgtttgcc aaattcaggc tgcctcctat ttttagagtc ttcctgaaac   3300

acagctacac ccgtattatc catggctgct ttcctgtcac agtgagtaag tagctgggac   3360

tgagaaggca tggcctccaa agtctaaaat atttactctc tagcactttg tagaaaaacc   3420

ttagctaggc acagtggcta acgcctgtaa tcccagcatt ttgggaggcc aaggcaggca   3480

gatcacctga ggtcaggagt tccagaccag cctggccaac atggtgaaat cccatctcta   3540

caaaaataaa acagttagct gggcatgatg gcgggtgcct gtaatcccag ctactcggga   3600

ggctgaggca ggatagtcgc ttgaacccag gaggtggagg ttgcaatgag ccaagatcat   3660

gccactgcac tccagcctgg acgacagagt gagactccat cacaagaaaa aaagaacttt   3720

gtcaacctct gtcttagggc gccttgtcac aggcttcggg tcagacggat tcaaccttgc   3780

atcagccatt tgttagccag gtcactctgt tctttgtctg taaatgagat tgatcgttgt   3840

tcccactgag agtgtcagct ccttcccgta gagcaggcat gatgattgta ctcacctctg   3900

acaccattgt gagtgccaca ttccttccca cgtccttgtc actgtaagag atgcccacct   3960

gagcaccaac cccaggttat cttccccttt gtcttccagc cccccagaaa cagctacgac   4020

tcaacctacc caatcatttc atcatcagat tgccactgtc tctagttcag gtctcttggg   4080

actggcactc agaaatctca taataaatcc tcttgaggct tctcatacac tcgtcttctt   4140

ccaatcttct ttccctcaaa atctcatatt ttggttccac ttcacccacc gtcattctcc   4200

atatcactcc caggagttag gcaaaaagcc ccttccgttc ttccgtatgt taaacttaga   4260

atcactctgt tccctgctct gcgtttctat tttttgtttt tcctccattt actagtagct   4320

taacactttc taacagtgtt cttattattg atacgtatct atctcttcca taagcttata   4380

aggtcacgga taatacttct cattgtagta cgtaaatgac gtgggctaga tatgagttga   4440

ataaacagtt atacctgtaa attcttacag agtgaaaata aattgttata ctttacaatt   4500

tgtttctctc tttagaccat ttccaggact tgtgattaat aaccgtgagt attttgtgaa   4560

gtgttttgtt tttgtttttt cctggggtct gacgtgtgtg cgtgtgagtg tgtatacatg   4620

cttaacgtat atcacgttac ttcacctatg tcagtaacca ggccaaatac ttgttttagc   4680

cctcagtaaa aacaccaggc acttcctagt tgtaaaatta ttcaagcttc ttaacttcct   4740

atcctcgatg cacttaatca taaaatggta ataatagcac cgattttggg ggagtcgttc   4800

cagtagatgg aaagcatctg gaacaggtgt cagcaagctc ctgccgacgt gtatgcataa   4860

agttttattg aaaccaccat cgtgtccatt tgtttatggc agaactgaga gatggcagca   4920

gcaagtgtgt gcctgcaaaa cctaaaatat ttactaattg gctctgcaag aaaagagttt   4980

gcatccccct aacctagaac agtgtctagc ctctagtatg tgtttagcct acagtatgtg   5040

ctcagcgaat acaatctata tttattactg cttttatgac tgttataatt actgtgcttg   5100

gatttcgtta caaagtaagt cacaatgtgc ctgcttctgt tagtatttca gcacagtgcc   5160

tggcacacat ggggctctca aatattgctg agcgagtgaa caaatgtcct ttcaattcct   5220

taacgttgat gtcattttca atagtatttt gagccaaact taattttgcg agtgtgtttt   5280

gttttcttaa ctttattatt aaaaatgtat aaaagtgagg ccaggcgtgg tggctcacgc   5340

ctgtaatccc agcagtttgg gaggctgagg caggcggatc agttgaggtt gggagttgga   5400

gaccagcccg tccaacatgg tgaaagcctg tctctactaa aaatacaaaa atcagctggg   5460

tgtggtggcg cgtgcctgta atcccagcta ctcaggaggc tgaggcagga gagttgcttg   5520

aatcctagag gtggaggttg cagtgagctg agatcgtgcc attgcactcc agcctgggca   5580

acaagagcaa aactctgtcc caataaataa ataaataaaa tgttctcttt tgttcctgtt   5640

cttgtgcggt agtgtggtat agagttttat ggtaattact gtgaattagt gattctgagg   5700

gacatatcag aactctgagg tttgtttcct tctcatcttg agggaaacag caaatgtatg   5760

ttaaaatgct tttccaaggg aacaacacat ccttacatta tttaaaccaa tctgcttcat   5820

tttcagagct ggttgatcag agtgagtcag aaggccccgt gatacaagaa tcagctgaac   5880

caagccagtt ggaagttcca gccacagaag aaataaaaga gactgatgga agctctcaga   5940

tcaagcaaga accagacccc acgtggtaga cctcttccct cctagggtaa atcagcttct   6000

gtgtcaggga tgctgtgtgg tgtccatctg aaccccctgc atacgcgtag ctaatgtgat   6060

ctccccactt tcacataaga tggtggccct gccttcaggg aatgtgggag ccaggtggga   6120

gccttcccgg atatttaagc tagaagattc tacagggaga ttctccttgg atcaatatat   6180

gtctctcagt caaagatgta aaagcacttt tgccttaaaa agaatgttct gtttctaaat   6240

agagtcaacg ttgtcctcct cattggaatt cactatgagt cagaatcatt agactgactt   6300

ttttttttcc atagtaatag tattttgcag agtctcacag agctgcagat cttttgttca   6360

tcttgcagag ttaacaagtc tgatcctgtt agtccagatt tcttaaattt ggccaagtta   6420

taataggagc agtagcttga gacccgaagt caggaaactt tgacaatgga tttttttttt   6480

taatccagag acttgtactg gaatttgcct taccctgtca gctcatggac ttaaggtttc   6540

atcccgcttt atgagtgctt ctgaatccaa gtcattgtta cctgaatttg caaattaagt   6600

tgtgatattc gtgactgtta aattcctgta attagattaa cctctttgct tgcttgtttg   6660

ttttctctcc tattttagct taaagtatca gtggttgaga agagcttttc ggacctgtta   6720

ctaccccaag ctgtgtaata tacttgtata acagaaatac cttctataca aacctttttt   6780

tctactttta gatagaaatg tctacttttt cagcagttct gtgaattaaa gagcagagtg   6840

actgtgggtc tggaatggct ggtgtacttg ggaatgtact atcaggattt tacagcaatg   6900

ctgggaaatg acagggaaaa tgacaggaat gaatctcacc agatttttta tgtactcagc   6960

agagccttga gttacggtgt ttattttcca atcaagtgaa gatatctcct acttctccta   7020

ctggaacatc tcagcttctg cagtgaagaa aaattcctgt gatagttcag ttctttagtt   7080

tttctatttg aaaaaaaaaa atcatttaaa tgatcctttg ttcacggctc tccttaatga   7140

ctgagtgaac agttcctatc tgtatatttg actaaacctt ttcctaagct atctctcatg   7200

gttcctatgt ttttttatca taattaaaag caaaaccatc tggatcacct aacagtcaga   7260

ggtcagtatc tcagcgtgtg aattatagag gaaatacaga gagaacctct tccactttta   7320

cttttcgtcc aaataaaatg catggtgtac cagaagttga agatcgggtt gaggattggg   7380

gctagctcga tgacactaag gccccaacat cgcgggacct gctgtggcgc ggattcttag   7440

gaacgctgtt ctagccggcc ccctctccag gggtcgccgt ggccggcatt atttcctagt   7500

tcttcttgta accctgaggt gccagcgcgg ggagtgagga ggggtcaggg ggctaaggat   7560

gcaacctctg acgttctgcg ccttcctagg agagtcttac atgtgttgag atttcacaag   7620

caatgcgagt tgtaaaatac cagctctaca agaagctagg ctctgtgacg gcatagtttt   7680

cagtagcttt atcacaatat tcacaatgga gaattatatg acatggtagc agaaataggc   7740

ccttttatgt gttgcttcta ttttacctca aattgtagat atagggtaat caataaaatc   7800

catccatgcc tttcacacac taagt                                         7825


<210>  4755
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  4755

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
                565                 570                 575


Ser Ser Leu Leu Lys Asn Leu Asn 
            580


<210>  4756
<211>  5047
<212>  DNA
<213>  Homo sapiens

<400>  4756
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   2040

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   2100

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2160

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2220

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2280

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2340

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2400

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2460

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2520

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2580

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2640

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2700

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2760

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2820

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2880

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2940

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   3000

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   3060

cggtcattag accatttcca ggacttgtga ttaataacca gctggttgat cagagtgagt   3120

cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt ccagccacag   3180

aaggtaaaag gacctcttcc ctcctagggt aaatcagctt ctgtgtcagg gatgctgtgt   3240

ggtgtccatc tgaaccccct gcatacgcgt agctaatgtg atctccccac tttcacataa   3300

gatggtggcc ctgccttcag ggaatgtggg agccaggtgg gagccttccc ggatatttaa   3360

gctagaagat tctacaggga gattctcctt ggatcaatat atgtctctca gtcaaagatg   3420

taaaagcact tttgccttaa aaagaatgtt ctgtttctaa atagagtcaa cgttgtcctc   3480

ctcattggaa ttcactatga gtcagaatca ttagactgac tttttttttt ccatagtaat   3540

agtattttgc agagtctcac agagctgcag atcttttgtt catcttgcag agttaacaag   3600

tctgatcctg ttagtccaga tttcttaaat ttggccaagt tataatagga gcagtagctt   3660

gagacccgaa gtcaggaaac tttgacaatg gatttttttt tttaatccag agacttgtac   3720

tggaatttgc cttaccctgt cagctcatgg acttaaggtt tcatcccgct ttatgagtgc   3780

ttctgaatcc aagtcattgt tacctgaatt tgcaaattaa gttgtgatat tcgtgactgt   3840

taaattcctg taattagatt aacctctttg cttgcttgtt tgttttctct cctattttag   3900

cttaaagtat cagtggttga gaagagcttt tcggacctgt tactacccca agctgtgtaa   3960

tatacttgta taacagaaat accttctata caaacctttt tttctacttt tagatagaaa   4020

tgtctacttt ttcagcagtt ctgtgaatta aagagcagag tgactgtggg tctggaatgg   4080

ctggtgtact tgggaatgta ctatcaggat tttacagcaa tgctgggaaa tgacagggaa   4140

aatgacagga atgaatctca ccagattttt tatgtactca gcagagcctt gagttacggt   4200

gtttattttc caatcaagtg aagatatctc ctacttctcc tactggaaca tctcagcttc   4260

tgcagtgaag aaaaattcct gtgatagttc agttctttag tttttctatt tgaaaaaaaa   4320

aaatcattta aatgatcctt tgttcacggc tctccttaat gactgagtga acagttccta   4380

tctgtatatt tgactaaacc ttttcctaag ctatctctca tggttcctat gtttttttat   4440

cataattaaa agcaaaacca tctggatcac ctaacagtca gaggtcagta tctcagcgtg   4500

tgaattatag aggaaataca gagagaacct cttccacttt tacttttcgt ccaaataaaa   4560

tgcatggtgt accagaagtt gaagatcggg ttgaggattg gggctagctc gatgacacta   4620

aggccccaac atcgcgggac ctgctgtggc gcggattctt aggaacgctg ttctagccgg   4680

ccccctctcc aggggtcgcc gtggccggca ttatttccta gttcttcttg taaccctgag   4740

gtgccagcgc ggggagtgag gaggggtcag ggggctaagg atgcaacctc tgacgttctg   4800

cgccttccta ggagagtctt acatgtgttg agatttcaca agcaatgcga gttgtaaaat   4860

accagctcta caagaagcta ggctctgtga cggcatagtt ttcagtagct ttatcacaat   4920

attcacaatg gagaattata tgacatggta gcagaaatag gcccttttat gtgttgcttc   4980

tattttacct caaattgtag atatagggta atcaataaaa tccatccatg cctttcacac   5040

actaagt                                                             5047


<210>  4757
<211>  875
<212>  PRT
<213>  Homo sapiens

<400>  4757

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
465                 470                 475                 480


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
                485                 490                 495


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
            500                 505                 510


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
        515                 520                 525


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
    530                 535                 540


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
545                 550                 555                 560


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
                565                 570                 575


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
            580                 585                 590


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
        595                 600                 605


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
    610                 615                 620


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
625                 630                 635                 640


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
                645                 650                 655


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
            660                 665                 670


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
        675                 680                 685


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
    690                 695                 700


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
705                 710                 715                 720


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
                725                 730                 735


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
            740                 745                 750


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
        755                 760                 765


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
    770                 775                 780


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
785                 790                 795                 800


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
                805                 810                 815


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro 
            820                 825                 830


Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly 
        835                 840                 845


Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala 
    850                 855                 860


Thr Glu Gly Lys Arg Thr Ser Ser Leu Leu Gly 
865                 870                 875


<210>  4758
<211>  5163
<212>  DNA
<213>  Homo sapiens

<400>  4758
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2040

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2100

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2160

tgaatcaaac ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag   2220

ccctacctgg tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa   2280

gttcgttgtt aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa   2340

aataaacact aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa   2400

ggttcctgaa attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc   2460

tgttcgaacc ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga   2520

gttttccttt gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct   2580

cttcaatgag aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc   2640

gttatttgag tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt   2700

ccgaagacca tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa   2760

aattaagttc atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc   2820

ctctaagagc cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg   2880

tgttgaagac cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc   2940

gaaagttgaa aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt   3000

tggtgaagct attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa   3060

ccctggctgt gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta   3120

cctggaaatc agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt   3180

cattagacca tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga   3240

aggccccgtg atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaagg   3300

taaaaggacc tcttccctcc tagggtaaat cagcttctgt gtcagggatg ctgtgtggtg   3360

tccatctgaa ccccctgcat acgcgtagct aatgtgatct ccccactttc acataagatg   3420

gtggccctgc cttcagggaa tgtgggagcc aggtgggagc cttcccggat atttaagcta   3480

gaagattcta cagggagatt ctccttggat caatatatgt ctctcagtca aagatgtaaa   3540

agcacttttg ccttaaaaag aatgttctgt ttctaaatag agtcaacgtt gtcctcctca   3600

ttggaattca ctatgagtca gaatcattag actgactttt ttttttccat agtaatagta   3660

ttttgcagag tctcacagag ctgcagatct tttgttcatc ttgcagagtt aacaagtctg   3720

atcctgttag tccagatttc ttaaatttgg ccaagttata ataggagcag tagcttgaga   3780

cccgaagtca ggaaactttg acaatggatt ttttttttta atccagagac ttgtactgga   3840

atttgcctta ccctgtcagc tcatggactt aaggtttcat cccgctttat gagtgcttct   3900

gaatccaagt cattgttacc tgaatttgca aattaagttg tgatattcgt gactgttaaa   3960

ttcctgtaat tagattaacc tctttgcttg cttgtttgtt ttctctccta ttttagctta   4020

aagtatcagt ggttgagaag agcttttcgg acctgttact accccaagct gtgtaatata   4080

cttgtataac agaaatacct tctatacaaa cctttttttc tacttttaga tagaaatgtc   4140

tactttttca gcagttctgt gaattaaaga gcagagtgac tgtgggtctg gaatggctgg   4200

tgtacttggg aatgtactat caggatttta cagcaatgct gggaaatgac agggaaaatg   4260

acaggaatga atctcaccag attttttatg tactcagcag agccttgagt tacggtgttt   4320

attttccaat caagtgaaga tatctcctac ttctcctact ggaacatctc agcttctgca   4380

gtgaagaaaa attcctgtga tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat   4440

catttaaatg atcctttgtt cacggctctc cttaatgact gagtgaacag ttcctatctg   4500

tatatttgac taaacctttt cctaagctat ctctcatggt tcctatgttt ttttatcata   4560

attaaaagca aaaccatctg gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa   4620

ttatagagga aatacagaga gaacctcttc cacttttact tttcgtccaa ataaaatgca   4680

tggtgtacca gaagttgaag atcgggttga ggattggggc tagctcgatg acactaaggc   4740

cccaacatcg cgggacctgc tgtggcgcgg attcttagga acgctgttct agccggcccc   4800

ctctccaggg gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac cctgaggtgc   4860

cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc   4920

ttcctaggag agtcttacat gtgttgagat ttcacaagca atgcgagttg taaaatacca   4980

gctctacaag aagctaggct ctgtgacggc atagttttca gtagctttat cacaatattc   5040

acaatggaga attatatgac atggtagcag aaataggccc ttttatgtgt tgcttctatt   5100

ttacctcaaa ttgtagatat agggtaatca ataaaatcca tccatgcctt tcacacacta   5160

agt                                                                 5163


<210>  4759
<211>  968
<212>  PRT
<213>  Homo sapiens

<400>  4759

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu 
            580                 585                 590


Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg 
        595                 600                 605


Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys 
    610                 615                 620


Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys 
625                 630                 635                 640


Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly 
                645                 650                 655


Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn 
            660                 665                 670


Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn 
        675                 680                 685


Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu 
    690                 695                 700


Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu 
705                 710                 715                 720


Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys 
                725                 730                 735


Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu 
            740                 745                 750


Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile 
        755                 760                 765


Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile 
    770                 775                 780


Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser 
785                 790                 795                 800


Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr 
                805                 810                 815


Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro 
            820                 825                 830


Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu 
        835                 840                 845


Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile 
    850                 855                 860


Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn 
865                 870                 875                 880


Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys 
                885                 890                 895


Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser 
            900                 905                 910


Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val 
        915                 920                 925


Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile 
    930                 935                 940


Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Gly 
945                 950                 955                 960


Lys Arg Thr Ser Ser Leu Leu Gly 
                965


<210>  4760
<211>  4370
<212>  DNA
<213>  Homo sapiens

<400>  4760
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagc tcaagctctt ggactcaccg   1980

aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag   2040

gcttgccaga ggggattccc ttccgaagcc ctacctggtt tggaattcca cgacttgaaa   2100

ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt   2160

cctacttgcc tcctgggatg gctagtaaaa taaacactaa agctttgcag tcccccaaaa   2220

gaccacgaag tcctgggagt aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc   2280

ctaataacaa caatcctcaa acctcagctg ttcgaacccc gacccagact aacggttcta   2340

acgttccctt caagccacga gggagagagt tttcctttga ggcctggaat gccaaaatca   2400

cggacctaaa acagaaagtt gaaaatctct tcaatgagaa atgtggggaa gctcttggcc   2460

ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc tttcccggaa gacttttatg   2520

tggaaggctt acctgagggt gtgccattcc gaagaccatc gacttttggc attccgaggc   2580

tggagaagat actcagaaac aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt   2640

ttgagacggc gattaaggag agcacctcct ctaagagccc tcccagaaaa ataaattcat   2700

cacccaatgt taatactact gcatcaggtg ttgaagacct taacatcatt caggtgacaa   2760

ttccagatga tgataatgaa agactctcga aagttgaaaa agctagacag ctaagagaac   2820

aagtgaatga cctctttagt cggaaatttg gtgaagctat tggtatgggt tttcctgtga   2880

aagttcccta caggaaaatc acaattaacc ctggctgtgt ggtggttgat ggcatgcccc   2940

cgggggtgtc cttcaaagcc cccagctacc tggaaatcag ctccatgaga aggatcttag   3000

actctgccga gtttatcaaa ttcacggtca ttagaccatt tccaggactt gtgattaata   3060

accagctggt tgatcagagt gagtcagaag gccccgtgat acaagaatca gctgaaccaa   3120

gccagttgga agttccagcc acagaagaaa taaaagagac tgatggaagc tctcagatca   3180

agcaagaacc agaccccacg tggtagacct cttccctcct aggcttaaag tatcagtggt   3240

tgagaagagc ttttcggacc tgttactacc ccaagctgtg taatatactt gtataacaga   3300

aataccttct atacaaacct ttttttctac ttttagatag aaatgtctac tttttcagca   3360

gttctgtgaa ttaaagagca gagtgactgt gggtctggaa tggctggtgt acttgggaat   3420

gtactatcag gattttacag caatgctggg aaatgacagg gaaaatgaca ggaatgaatc   3480

tcaccagatt ttttatgtac tcagcagagc cttgagttac ggtgtttatt ttccaatcaa   3540

gtgaagatat ctcctacttc tcctactgga acatctcagc ttctgcagtg aagaaaaatt   3600

cctgtgatag ttcagttctt tagtttttct atttgaaaaa aaaaaatcat ttaaatgatc   3660

ctttgttcac ggctctcctt aatgactgag tgaacagttc ctatctgtat atttgactaa   3720

accttttcct aagctatctc tcatggttcc tatgtttttt tatcataatt aaaagcaaaa   3780

ccatctggat cacctaacag tcagaggtca gtatctcagc gtgtgaatta tagaggaaat   3840

acagagagaa cctcttccac ttttactttt cgtccaaata aaatgcatgg tgtaccagaa   3900

gttgaagatc gggttgagga ttggggctag ctcgatgaca ctaaggcccc aacatcgcgg   3960

gacctgctgt ggcgcggatt cttaggaacg ctgttctagc cggccccctc tccaggggtc   4020

gccgtggccg gcattatttc ctagttcttc ttgtaaccct gaggtgccag cgcggggagt   4080

gaggaggggt cagggggcta aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt   4140

cttacatgtg ttgagatttc acaagcaatg cgagttgtaa aataccagct ctacaagaag   4200

ctaggctctg tgacggcata gttttcagta gctttatcac aatattcaca atggagaatt   4260

atatgacatg gtagcagaaa taggcccttt tatgtgttgc ttctatttta cctcaaattg   4320

tagatatagg gtaatcaata aaatccatcc atgcctttca cacactaagt              4370


<210>  4761
<211>  934
<212>  PRT
<213>  Homo sapiens

<400>  4761

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala 
        515                 520                 525


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr 
    530                 535                 540


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe 
545                 550                 555                 560


Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys 
                565                 570                 575


Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly 
            580                 585                 590


Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro 
        595                 600                 605


Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val 
    610                 615                 620


Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro 
625                 630                 635                 640


Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu 
                645                 650                 655


Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys 
            660                 665                 670


Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys 
        675                 680                 685


Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp 
    690                 695                 700


Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser 
705                 710                 715                 720


Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys 
                725                 730                 735


Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys 
            740                 745                 750


Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro 
        755                 760                 765


Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln 
    770                 775                 780


Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys 
785                 790                 795                 800


Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe 
                805                 810                 815


Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys 
            820                 825                 830


Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly 
        835                 840                 845


Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg 
    850                 855                 860


Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe 
865                 870                 875                 880


Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu 
                885                 890                 895


Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro 
            900                 905                 910


Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln 
        915                 920                 925


Glu Pro Asp Pro Thr Trp 
    930


<210>  4762
<211>  7205
<212>  DNA
<213>  Homo sapiens

<400>  4762
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gtcaaagaag attggaatgt   1980

cagaattacc aagctacgga agcaagtgga agagattttt aatttgaaat ttgctcaagc   2040

tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt   2100

cttgtatgtg gaaggcttgc cagaggggat tcccttccga agccctacct ggtttggaat   2160

tccacgactt gaaaggatcg tccgcgggag taataaaatc aagttcgttg ttaaaaaacc   2220

tgaactagtt atttcctact tgcctcctgg gatggctagt aaaataaaca ctaaagcttt   2280

gcagtccccc aaaagaccac gaagtcctgg gagtaattca aaggttcctg aaattgaggt   2340

caccgtggaa ggccctaata acaacaatcc tcaaacctca gctgttcgaa ccccgaccca   2400

gactaacggt tctaacgttc ccttcaagcc acgagggaga gagttttcct ttgaggcctg   2460

gaatgccaaa atcacggacc taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg   2520

ggaagctctt ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg agtctttccc   2580

ggaagacttt tatgtggaag gcttacctga gggtgtgcca ttccgaagac catcgacttt   2640

tggcattccg aggctggaga agatactcag aaacaaagcc aaaattaagt tcatcattaa   2700

aaagcccgaa atgtttgaga cggcgattaa ggagagcacc tcctctaaga gccctcccag   2760

aaaaataaat tcatcaccca atgttaatac tactgcatca ggtgttgaag accttaacat   2820

cattcaggtg acaattccag atgatgataa tgaaagactc tcgaaagttg aaaaagctag   2880

acagctaaga gaacaagtga atgacctctt tagtcggaaa tttggtgaag ctattggtat   2940

gggttttcct gtgaaagttc cctacaggaa aatcacaatt aaccctggct gtgtggtggt   3000

tgatggcatg cccccggggg tgtccttcaa agcccccagc tacctggaaa tcagctccat   3060

gagaaggatc ttagactctg ccgagtttat caaattcacg gtcattaggt aagtgagagt   3120

ttcctgctta gtcacaggag cgaatctgga gctcatgagg ctgactcttc taaaatgcag   3180

ccacaggtag tcatcgaatc cggcttccta tgctgtgcaa tcaacaaatc aaaataactt   3240

gtgtcatcat tagaatgtca gatgtgcttc tacgaactaa gctgactctt ttaattcttt   3300

ggcaaagggt tggcaaacta ggactgtttg ccaaattcag gctgcctcct atttttagag   3360

tcttcctgaa acacagctac acccgtatta tccatggctg ctttcctgtc acagtgagta   3420

agtagctggg actgagaagg catggcctcc aaagtctaaa atatttactc tctagcactt   3480

tgtagaaaaa ccttagctag gcacagtggc taacgcctgt aatcccagca ttttgggagg   3540

ccaaggcagg cagatcacct gaggtcagga gttccagacc agcctggcca acatggtgaa   3600

atcccatctc tacaaaaata aaacagttag ctgggcatga tggcgggtgc ctgtaatccc   3660

agctactcgg gaggctgagg caggatagtc gcttgaaccc aggaggtgga ggttgcaatg   3720

agccaagatc atgccactgc actccagcct ggacgacaga gtgagactcc atcacaagaa   3780

aaaaagaact ttgtcaacct ctgtcttagg gcgccttgtc acaggcttcg ggtcagacgg   3840

attcaacctt gcatcagcca tttgttagcc aggtcactct gttctttgtc tgtaaatgag   3900

attgatcgtt gttcccactg agagtgtcag ctccttcccg tagagcaggc atgatgattg   3960

tactcacctc tgacaccatt gtgagtgcca cattccttcc cacgtccttg tcactgtaag   4020

agatgcccac ctgagcacca accccaggtt atcttcccct ttgtcttcca gccccccaga   4080

aacagctacg actcaaccta cccaatcatt tcatcatcag attgccactg tctctagttc   4140

aggtctcttg ggactggcac tcagaaatct cataataaat cctcttgagg cttctcatac   4200

actcgtcttc ttccaatctt ctttccctca aaatctcata ttttggttcc acttcaccca   4260

ccgtcattct ccatatcact cccaggagtt aggcaaaaag ccccttccgt tcttccgtat   4320

gttaaactta gaatcactct gttccctgct ctgcgtttct attttttgtt tttcctccat   4380

ttactagtag cttaacactt tctaacagtg ttcttattat tgatacgtat ctatctcttc   4440

cataagctta taaggtcacg gataatactt ctcattgtag tacgtaaatg acgtgggcta   4500

gatatgagtt gaataaacag ttatacctgt aaattcttac agagtgaaaa taaattgtta   4560

tactttacaa tttgtttctc tctttagacc atttccagga cttgtgatta ataaccgtga   4620

gtattttgtg aagtgttttg tttttgtttt ttcctggggt ctgacgtgtg tgcgtgtgag   4680

tgtgtataca tgcttaacgt atatcacgtt acttcaccta tgtcagtaac caggccaaat   4740

acttgtttta gccctcagta aaaacaccag gcacttccta gttgtaaaat tattcaagct   4800

tcttaacttc ctatcctcga tgcacttaat cataaaatgg taataatagc accgattttg   4860

ggggagtcgt tccagtagat ggaaagcatc tggaacaggt gtcagcaagc tcctgccgac   4920

gtgtatgcat aaagttttat tgaaaccacc atcgtgtcca tttgtttatg gcagaactga   4980

gagatggcag cagcaagtgt gtgcctgcaa aacctaaaat atttactaat tggctctgca   5040

agaaaagagt ttgcatcccc ctaacctaga acagtgtcta gcctctagta tgtgtttagc   5100

ctacagtatg tgctcagcga atacaatcta tatttattac tgcttttatg actgttataa   5160

ttactgtgct tggatttcgt tacaaagtaa gtcacaatgt gcctgcttct gttagtattt   5220

cagcacagtg cctggcacac atggggctct caaatattgc tgagcgagtg aacaaatgtc   5280

ctttcaattc cttaacgttg atgtcatttt caatagtatt ttgagccaaa cttaattttg   5340

cgagtgtgtt ttgttttctt aactttatta ttaaaaatgt ataaaagtga ggccaggcgt   5400

ggtggctcac gcctgtaatc ccagcagttt gggaggctga ggcaggcgga tcagttgagg   5460

ttgggagttg gagaccagcc cgtccaacat ggtgaaagcc tgtctctact aaaaatacaa   5520

aaatcagctg ggtgtggtgg cgcgtgcctg taatcccagc tactcaggag gctgaggcag   5580

gagagttgct tgaatcctag aggtggaggt tgcagtgagc tgagatcgtg ccattgcact   5640

ccagcctggg caacaagagc aaaactctgt cccaataaat aaataaataa aatgttctct   5700

tttgttcctg ttcttgtgcg gtagtgtggt atagagtttt atggtaatta ctgtgaatta   5760

gtgattctga gggacatatc agaactctga ggtttgtttc cttctcatct tgagggaaac   5820

agcaaatgta tgttaaaatg cttttccaag ggaacaacac atccttacat tatttaaacc   5880

aatctgcttc attttcagag ctggttgatc agagtgagtc agaaggcccc gtgatacaag   5940

aatcagctga accaagccag ttggaagttc cagccacaga agaaataaaa gagactgatg   6000

gaagctctca gatcaagcaa gaaccagacc ccacgtggta gacctcttcc ctcctaggct   6060

taaagtatca gtggttgaga agagcttttc ggacctgtta ctaccccaag ctgtgtaata   6120

tacttgtata acagaaatac cttctataca aacctttttt tctactttta gatagaaatg   6180

tctacttttt cagcagttct gtgaattaaa gagcagagtg actgtgggtc tggaatggct   6240

ggtgtacttg ggaatgtact atcaggattt tacagcaatg ctgggaaatg acagggaaaa   6300

tgacaggaat gaatctcacc agatttttta tgtactcagc agagccttga gttacggtgt   6360

ttattttcca atcaagtgaa gatatctcct acttctccta ctggaacatc tcagcttctg   6420

cagtgaagaa aaattcctgt gatagttcag ttctttagtt tttctatttg aaaaaaaaaa   6480

atcatttaaa tgatcctttg ttcacggctc tccttaatga ctgagtgaac agttcctatc   6540

tgtatatttg actaaacctt ttcctaagct atctctcatg gttcctatgt ttttttatca   6600

taattaaaag caaaaccatc tggatcacct aacagtcaga ggtcagtatc tcagcgtgtg   6660

aattatagag gaaatacaga gagaacctct tccactttta cttttcgtcc aaataaaatg   6720

catggtgtac cagaagttga agatcgggtt gaggattggg gctagctcga tgacactaag   6780

gccccaacat cgcgggacct gctgtggcgc ggattcttag gaacgctgtt ctagccggcc   6840

ccctctccag gggtcgccgt ggccggcatt atttcctagt tcttcttgta accctgaggt   6900

gccagcgcgg ggagtgagga ggggtcaggg ggctaaggat gcaacctctg acgttctgcg   6960

ccttcctagg agagtcttac atgtgttgag atttcacaag caatgcgagt tgtaaaatac   7020

cagctctaca agaagctagg ctctgtgacg gcatagtttt cagtagcttt atcacaatat   7080

tcacaatgga gaattatatg acatggtagc agaaataggc ccttttatgt gttgcttcta   7140

ttttacctca aattgtagat atagggtaat caataaaatc catccatgcc tttcacacac   7200

taagt                                                               7205


<210>  4763
<211>  896
<212>  PRT
<213>  Homo sapiens

<400>  4763

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr 
                565                 570                 575


Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys 
            580                 585                 590


Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro 
        595                 600                 605


Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys 
    610                 615                 620


Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val 
625                 630                 635                 640


Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg 
                645                 650                 655


Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly 
            660                 665                 670


Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys 
        675                 680                 685


Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly 
    690                 695                 700


Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro 
705                 710                 715                 720


Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg 
                725                 730                 735


Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys 
            740                 745                 750


Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala 
        755                 760                 765


Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser 
    770                 775                 780


Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile 
785                 790                 795                 800


Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val 
                805                 810                 815


Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg 
            820                 825                 830


Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr 
        835                 840                 845


Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro 
    850                 855                 860


Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met 
865                 870                 875                 880


Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
                885                 890                 895


<210>  4764
<211>  5223
<212>  DNA
<213>  Homo sapiens

<400>  4764
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2100

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2160

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2220

tgaatcaaac ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag   2280

ccctacctgg tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa   2340

gttcgttgtt aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa   2400

aataaacact aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa   2460

ggttcctgaa attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc   2520

tgttcgaacc ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga   2580

gttttccttt gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct   2640

cttcaatgag aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc   2700

gttatttgag tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt   2760

ccgaagacca tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa   2820

aattaagttc atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc   2880

ctctaagagc cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg   2940

tgttgaagac cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc   3000

gaaagttgaa aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt   3060

tggtgaagct attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa   3120

ccctggctgt gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta   3180

cctggaaatc agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt   3240

cattagacca tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga   3300

aggccccgtg atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaagg   3360

taaaaggacc tcttccctcc tagggtaaat cagcttctgt gtcagggatg ctgtgtggtg   3420

tccatctgaa ccccctgcat acgcgtagct aatgtgatct ccccactttc acataagatg   3480

gtggccctgc cttcagggaa tgtgggagcc aggtgggagc cttcccggat atttaagcta   3540

gaagattcta cagggagatt ctccttggat caatatatgt ctctcagtca aagatgtaaa   3600

agcacttttg ccttaaaaag aatgttctgt ttctaaatag agtcaacgtt gtcctcctca   3660

ttggaattca ctatgagtca gaatcattag actgactttt ttttttccat agtaatagta   3720

ttttgcagag tctcacagag ctgcagatct tttgttcatc ttgcagagtt aacaagtctg   3780

atcctgttag tccagatttc ttaaatttgg ccaagttata ataggagcag tagcttgaga   3840

cccgaagtca ggaaactttg acaatggatt ttttttttta atccagagac ttgtactgga   3900

atttgcctta ccctgtcagc tcatggactt aaggtttcat cccgctttat gagtgcttct   3960

gaatccaagt cattgttacc tgaatttgca aattaagttg tgatattcgt gactgttaaa   4020

ttcctgtaat tagattaacc tctttgcttg cttgtttgtt ttctctccta ttttagctta   4080

aagtatcagt ggttgagaag agcttttcgg acctgttact accccaagct gtgtaatata   4140

cttgtataac agaaatacct tctatacaaa cctttttttc tacttttaga tagaaatgtc   4200

tactttttca gcagttctgt gaattaaaga gcagagtgac tgtgggtctg gaatggctgg   4260

tgtacttggg aatgtactat caggatttta cagcaatgct gggaaatgac agggaaaatg   4320

acaggaatga atctcaccag attttttatg tactcagcag agccttgagt tacggtgttt   4380

attttccaat caagtgaaga tatctcctac ttctcctact ggaacatctc agcttctgca   4440

gtgaagaaaa attcctgtga tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat   4500

catttaaatg atcctttgtt cacggctctc cttaatgact gagtgaacag ttcctatctg   4560

tatatttgac taaacctttt cctaagctat ctctcatggt tcctatgttt ttttatcata   4620

attaaaagca aaaccatctg gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa   4680

ttatagagga aatacagaga gaacctcttc cacttttact tttcgtccaa ataaaatgca   4740

tggtgtacca gaagttgaag atcgggttga ggattggggc tagctcgatg acactaaggc   4800

cccaacatcg cgggacctgc tgtggcgcgg attcttagga acgctgttct agccggcccc   4860

ctctccaggg gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac cctgaggtgc   4920

cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc   4980

ttcctaggag agtcttacat gtgttgagat ttcacaagca atgcgagttg taaaatacca   5040

gctctacaag aagctaggct ctgtgacggc atagttttca gtagctttat cacaatattc   5100

acaatggaga attatatgac atggtagcag aaataggccc ttttatgtgt tgcttctatt   5160

ttacctcaaa ttgtagatat agggtaatca ataaaatcca tccatgcctt tcacacacta   5220

agt                                                                 5223


<210>  4765
<211>  988
<212>  PRT
<213>  Homo sapiens

<400>  4765

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr 
        595                 600                 605


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe 
    610                 615                 620


Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys 
625                 630                 635                 640


Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly 
                645                 650                 655


Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro 
            660                 665                 670


Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val 
        675                 680                 685


Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro 
    690                 695                 700


Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu 
705                 710                 715                 720


Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys 
                725                 730                 735


Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys 
            740                 745                 750


Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp 
        755                 760                 765


Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser 
    770                 775                 780


Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys 
785                 790                 795                 800


Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys 
                805                 810                 815


Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro 
            820                 825                 830


Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln 
        835                 840                 845


Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys 
    850                 855                 860


Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe 
865                 870                 875                 880


Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys 
                885                 890                 895


Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly 
            900                 905                 910


Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg 
        915                 920                 925


Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe 
    930                 935                 940


Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu 
945                 950                 955                 960


Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro 
                965                 970                 975


Ala Thr Glu Gly Lys Arg Thr Ser Ser Leu Leu Gly 
            980                 985


<210>  4766
<211>  4080
<212>  DNA
<213>  Homo sapiens

<400>  4766
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gtcaaagaag attggaatgt cagaattacc aagctacgga   1920

agcaagtgga agagattttt aatttgaaat ttgctcaagc tcttggactc accgaggcag   1980

taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgtatgtg gaaggcttgc   2040

cagaggggat tcccttccga agccctacct ggtttggaat tccacgactt gaaaggatcg   2100

tccgcgggag taataaaatc aagttcgttg ttaaaaaacc tgaactagtt atttcctact   2160

tgcctcctgg gatggctagt aaaataaaca ctaaagcttt gcagtccccc aaaagaccac   2220

gaagtcctgg gagtaattca aaggttcctg aaattgaggt caccgtggaa ggccctaata   2280

acaacaatcc tcaaacctca gctgttcgaa ccccgaccca gactaacggt tctaacgttc   2340

ccttcaagcc acgagggaga gagttttcct ttgaggcctg gaatgccaaa atcacggacc   2400

taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg ggaagctctt ggccttaaac   2460

aagctgtgaa ggtgccgttc gcgttatttg agtctttccc ggaagacttt tatgtggaag   2520

gcttacctga gggtgtgcca ttccgaagac catcgacttt tggcattccg aggctggaga   2580

agatactcag aaacaaagcc aaaattaagt tcatcattaa aaagcccgaa atgtttgaga   2640

cggcgattaa ggagagcacc tcctctaaga gccctcccag aaaaataaat tcatcaccca   2700

atgttaatac tactgcatca ggtgttgaag accttaacat cattcaggtg acaattccag   2760

atgatgataa tgaaagactc tcgaaagttg aaaaagctag acagctaaga gaacaagtga   2820

atgacctctt tagtcggaaa tttggtgaag ctattggtat gggttttcct gtgaaagttc   2880

cctacaggaa aatcacaatt aaccctggct gtgtggtggt tgatggcatg cccccggggg   2940

tgtccttcaa agcccccagc tacctggaaa tcagctccat gagaaggatc ttagactctg   3000

ccgagtttat caaattcacg gtcattagac catttccagg acttgtgatt aataaccagc   3060

tggttgatca gagtgagtca gaaggccccg tgatacaaga atcagctgaa ccaagccagt   3120

tggaagttcc agccacagaa gaaataaaag agactgatgg aagctctcag atcaagcaag   3180

aaccagaccc cacgtggtag acctcttccc tcctaggagc cttgagttac ggtgtttatt   3240

ttccaatcaa gtgaagatat ctcctacttc tcctactgga acatctcagc ttctgcagtg   3300

aagaaaaatt cctgtgatag ttcagttctt tagtttttct atttgaaaaa aaaaaatcat   3360

ttaaatgatc ctttgttcac ggctctcctt aatgactgag tgaacagttc ctatctgtat   3420

atttgactaa accttttcct aagctatctc tcatggttcc tatgtttttt tatcataatt   3480

aaaagcaaaa ccatctggat cacctaacag tcagaggtca gtatctcagc gtgtgaatta   3540

tagaggaaat acagagagaa cctcttccac ttttactttt cgtccaaata aaatgcatgg   3600

tgtaccagaa gttgaagatc gggttgagga ttggggctag ctcgatgaca ctaaggcccc   3660

aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg ctgttctagc cggccccctc   3720

tccaggggtc gccgtggccg gcattatttc ctagttcttc ttgtaaccct gaggtgccag   3780

cgcggggagt gaggaggggt cagggggcta aggatgcaac ctctgacgtt ctgcgccttc   3840

ctaggagagt cttacatgtg ttgagatttc acaagcaatg cgagttgtaa aataccagct   3900

ctacaagaag ctaggctctg tgacggcata gttttcagta gctttatcac aatattcaca   3960

atggagaatt atatgacatg gtagcagaaa taggcccttt tatgtgttgc ttctatttta   4020

cctcaaattg tagatatagg gtaatcaata aaatccatcc atgcctttca cacactaagt   4080


<210>  4767
<211>  932
<212>  PRT
<213>  Homo sapiens

<400>  4767

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
                485                 490                 495


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
            500                 505                 510


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
        515                 520                 525


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu 
    530                 535                 540


Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile 
545                 550                 555                 560


Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val 
                565                 570                 575


Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala 
            580                 585                 590


Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser 
        595                 600                 605


Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly 
    610                 615                 620


Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln 
625                 630                 635                 640


Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser 
                645                 650                 655


Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu 
            660                 665                 670


Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala 
        675                 680                 685


Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr 
    690                 695                 700


Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe 
705                 710                 715                 720


Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys 
                725                 730                 735


Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser 
            740                 745                 750


Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val 
        755                 760                 765


Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr 
    770                 775                 780


Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg 
785                 790                 795                 800


Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu 
                805                 810                 815


Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr 
            820                 825                 830


Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser 
        835                 840                 845


Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu 
    850                 855                 860


Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly 
865                 870                 875                 880


Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro 
                885                 890                 895


Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr 
            900                 905                 910


Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro 
        915                 920                 925


Asp Pro Thr Trp 
    930


<210>  4768
<211>  4224
<212>  DNA
<213>  Homo sapiens

<400>  4768
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1860

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1920

tgaaatttgc ttagatttgt tgacagcggt ttcctggagt gctgtcttga gaacgattct   1980

gaggaggctc agcaagaaag agtgtttcag ttgattgggt gtgtctgtca tggagaagga   2040

actcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac   2100

ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg   2160

tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2220

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2280

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2340

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2400

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2460

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2520

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2580

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2640

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2700

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2760

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2820

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2880

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2940

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   3000

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3060

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca   3120

tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg   3180

atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag   3240

actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc   3300

ctaggcttaa agtatcagtg gttgagaaga gcttttcgga cctgttacta ccccaagctg   3360

tagccttgag ttacggtgtt tattttccaa tcaagtgaag atatctccta cttctcctac   3420

tggaacatct cagcttctgc agtgaagaaa aattcctgtg atagttcagt tctttagttt   3480

ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt tcacggctct ccttaatgac   3540

tgagtgaaca gttcctatct gtatatttga ctaaaccttt tcctaagcta tctctcatgg   3600

ttcctatgtt tttttatcat aattaaaagc aaaaccatct ggatcaccta acagtcagag   3660

gtcagtatct cagcgtgtga attatagagg aaatacagag agaacctctt ccacttttac   3720

ttttcgtcca aataaaatgc atggtgtacc agaagttgaa gatcgggttg aggattgggg   3780

ctagctcgat gacactaagg ccccaacatc gcgggacctg ctgtggcgcg gattcttagg   3840

aacgctgttc tagccggccc cctctccagg ggtcgccgtg gccggcatta tttcctagtt   3900

cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg gctaaggatg   3960

caacctctga cgttctgcgc cttcctagga gagtcttaca tgtgttgaga tttcacaagc   4020

aatgcgagtt gtaaaatacc agctctacaa gaagctaggc tctgtgacgg catagttttc   4080

agtagcttta tcacaatatt cacaatggag aattatatga catggtagca gaaataggcc   4140

cttttatgtg ttgcttctat tttacctcaa attgtagata tagggtaatc aataaaatcc   4200

atccatgcct ttcacacact aagt                                          4224


<210>  4769
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  4769

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg 
            420                 425                 430


Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe 
        435                 440                 445


Ala 



<210>  4770
<211>  5326
<212>  DNA
<213>  Homo sapiens

<400>  4770
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2040

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2100

tttgaaattt gcttagattt gttgacagcg gtttcctgga gtgctgtctt gagaacgatt   2160

ctgaggaggc tcagcaagaa agagtgtttc agttgattgg gtgtgtctgt catggagaag   2220

gaactcaagc tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa   2280

acccggagtt cttgtatgtg gaaggcttgc cagaggggat tcccttccga agccctacct   2340

ggtttggaat tccacgactt gaaaggatcg tccgcgggag taataaaatc aagttcgttg   2400

ttaaaaaacc tgaactagtt atttcctact tgcctcctgg gatggctagt aaaataaaca   2460

ctaaagcttt gcagtccccc aaaagaccac gaagtcctgg gagtaattca aaggttcctg   2520

aaattgaggt caccgtggaa ggccctaata acaacaatcc tcaaacctca gctgttcgaa   2580

ccccgaccca gactaacggt tctaacgttc ccttcaagcc acgagggaga gagttttcct   2640

ttgaggcctg gaatgccaaa atcacggacc taaaacagaa agttgaaaat ctcttcaatg   2700

agaaatgtgg ggaagctctt ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg   2760

agtctttccc ggaagacttt tatgtggaag gcttacctga gggtgtgcca ttccgaagac   2820

catcgacttt tggcattccg aggctggaga agatactcag aaacaaagcc aaaattaagt   2880

tcatcattaa aaagcccgaa atgtttgaga cggcgattaa ggagagcacc tcctctaaga   2940

gccctcccag aaaaataaat tcatcaccca atgttaatac tactgcatca ggtgttgaag   3000

accttaacat cattcaggtg acaattccag atgatgataa tgaaagactc tcgaaagttg   3060

aaaaagctag acagctaaga gaacaagtga atgacctctt tagtcggaaa tttggtgaag   3120

ctattggtat gggttttcct gtgaaagttc cctacaggaa aatcacaatt aaccctggct   3180

gtgtggtggt tgatggcatg cccccggggg tgtccttcaa agcccccagc tacctggaaa   3240

tcagctccat gagaaggatc ttagactctg ccgagtttat caaattcacg gtcattagac   3300

catttccagg acttgtgatt aataaccagc tggttgatca gagtgagtca gaaggccccg   3360

tgatacaaga atcagctgaa ccaagccagt tggaagttcc agccacagaa gaaataaaag   3420

agactgatgg aagctctcag atcaagcaag aaccagaccc cacgtggtag acctcttccc   3480

tcctagggta aatcagcttc tgtgtcaggg atgctgtgtg gtgtccatct gaaccccctg   3540

catacgcgta gctaatgtga tctccccact ttcacataag atggtggccc tgccttcagg   3600

gaatgtggga gccaggtggg agccttcccg gatatttaag ctagaagatt ctacagggag   3660

attctccttg gatcaatata tgtctctcag tcaaagatgt aaaagcactt ttgccttaaa   3720

aagaatgttc tgtttctaaa tagagtcaac gttgtcctcc tcattggaat tcactatgag   3780

tcagaatcat tagactgact tttttttttc catagtaata gtattttgca gagtctcaca   3840

gagctgcaga tcttttgttc atcttgcaga gttaacaagt ctgatcctgt tagtccagat   3900

ttcttaaatt tggccaagtt ataataggag cagtagcttg agacccgaag tcaggaaact   3960

ttgacaatgg attttttttt ttaatccaga gacttgtact ggaatttgcc ttaccctgtc   4020

agctcatgga cttaaggttt catcccgctt tatgagtgct tctgaatcca agtcattgtt   4080

acctgaattt gcaaattaag ttgtgatatt cgtgactgtt aaattcctgt aattagatta   4140

acctctttgc ttgcttgttt gttttctctc ctattttagc ttaaagtatc agtggttgag   4200

aagagctttt cggacctgtt actaccccaa gctgtgtaat atacttgtat aacagaaata   4260

ccttctatac aaaccttttt ttctactttt agatagaaat gtctactttt tcagcagttc   4320

tgtgaattaa agagcagagt gactgtgggt ctggaatggc tggtgtactt gggaatgtac   4380

tatcaggatt ttacagcaat gctgggaaat gacagggaaa atgacaggaa tgaatctcac   4440

cagatttttt atgtactcag cagagccttg agttacggtg tttattttcc aatcaagtga   4500

agatatctcc tacttctcct actggaacat ctcagcttct gcagtgaaga aaaattcctg   4560

tgatagttca gttctttagt ttttctattt gaaaaaaaaa aatcatttaa atgatccttt   4620

gttcacggct ctccttaatg actgagtgaa cagttcctat ctgtatattt gactaaacct   4680

tttcctaagc tatctctcat ggttcctatg tttttttatc ataattaaaa gcaaaaccat   4740

ctggatcacc taacagtcag aggtcagtat ctcagcgtgt gaattataga ggaaatacag   4800

agagaacctc ttccactttt acttttcgtc caaataaaat gcatggtgta ccagaagttg   4860

aagatcgggt tgaggattgg ggctagctcg atgacactaa ggccccaaca tcgcgggacc   4920

tgctgtggcg cggattctta ggaacgctgt tctagccggc cccctctcca ggggtcgccg   4980

tggccggcat tatttcctag ttcttcttgt aaccctgagg tgccagcgcg gggagtgagg   5040

aggggtcagg gggctaagga tgcaacctct gacgttctgc gccttcctag gagagtctta   5100

catgtgttga gatttcacaa gcaatgcgag ttgtaaaata ccagctctac aagaagctag   5160

gctctgtgac ggcatagttt tcagtagctt tatcacaata ttcacaatgg agaattatat   5220

gacatggtag cagaaatagg cccttttatg tgttgcttct attttacctc aaattgtaga   5280

tatagggtaa tcaataaaat ccatccatgc ctttcacaca ctaagt                  5326


<210>  4771
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  4771

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala 



<210>  4772
<211>  5117
<212>  DNA
<213>  Homo sapiens

<400>  4772
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gtcaaagaag attggaatgt cagaattacc aagctacgga   1920

agcaagtgga agagattttt aatttgaaat ttgcttagat ttgttgacag cggtttcctg   1980

gagtgctgtc ttgagaacga ttctgaggag gctcagcaag aaagagtgtt tcagttgatt   2040

gggtgtgtct gtcatggaga aggaactcaa gctcttggac tcaccgaggc agtaaaagta   2100

ccatatcctg tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg   2160

attcccttcc gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg   2220

agtaataaaa tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct   2280

gggatggcta gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct   2340

gggagtaatt caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat   2400

cctcaaacct cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag   2460

ccacgaggga gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag   2520

aaagttgaaa atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg   2580

aaggtgccgt tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct   2640

gagggtgtgc cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc   2700

agaaacaaag ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt   2760

aaggagagca cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat   2820

actactgcat caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat   2880

aatgaaagac tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc   2940

tttagtcgga aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg   3000

aaaatcacaa ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc   3060

aaagccccca gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt   3120

atcaaattca cggtcattag accatttcca ggacttgtga ttaataacca gctggttgat   3180

cagagtgagt cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt   3240

ccagccacag aaggtaaaag gacctcttcc ctcctagggt aaatcagctt ctgtgtcagg   3300

gatgctgtgt ggtgtccatc tgaaccccct gcatacgcgt agctaatgtg atctccccac   3360

tttcacataa gatggtggcc ctgccttcag ggaatgtggg agccaggtgg gagccttccc   3420

ggatatttaa gctagaagat tctacaggga gattctcctt ggatcaatat atgtctctca   3480

gtcaaagatg taaaagcact tttgccttaa aaagaatgtt ctgtttctaa atagagtcaa   3540

cgttgtcctc ctcattggaa ttcactatga gtcagaatca ttagactgac tttttttttt   3600

ccatagtaat agtattttgc agagtctcac agagctgcag atcttttgtt catcttgcag   3660

agttaacaag tctgatcctg ttagtccaga tttcttaaat ttggccaagt tataatagga   3720

gcagtagctt gagacccgaa gtcaggaaac tttgacaatg gatttttttt tttaatccag   3780

agacttgtac tggaatttgc cttaccctgt cagctcatgg acttaaggtt tcatcccgct   3840

ttatgagtgc ttctgaatcc aagtcattgt tacctgaatt tgcaaattaa gttgtgatat   3900

tcgtgactgt taaattcctg taattagatt aacctctttg cttgcttgtt tgttttctct   3960

cctattttag cttaaagtat cagtggttga gaagagcttt tcggacctgt tactacccca   4020

agctgtgtaa tatacttgta taacagaaat accttctata caaacctttt tttctacttt   4080

tagatagaaa tgtctacttt ttcagcagtt ctgtgaatta aagagcagag tgactgtggg   4140

tctggaatgg ctggtgtact tgggaatgta ctatcaggat tttacagcaa tgctgggaaa   4200

tgacagggaa aatgacagga atgaatctca ccagattttt tatgtactca gcagagcctt   4260

gagttacggt gtttattttc caatcaagtg aagatatctc ctacttctcc tactggaaca   4320

tctcagcttc tgcagtgaag aaaaattcct gtgatagttc agttctttag tttttctatt   4380

tgaaaaaaaa aaatcattta aatgatcctt tgttcacggc tctccttaat gactgagtga   4440

acagttccta tctgtatatt tgactaaacc ttttcctaag ctatctctca tggttcctat   4500

gtttttttat cataattaaa agcaaaacca tctggatcac ctaacagtca gaggtcagta   4560

tctcagcgtg tgaattatag aggaaataca gagagaacct cttccacttt tacttttcgt   4620

ccaaataaaa tgcatggtgt accagaagtt gaagatcggg ttgaggattg gggctagctc   4680

gatgacacta aggccccaac atcgcgggac ctgctgtggc gcggattctt aggaacgctg   4740

ttctagccgg ccccctctcc aggggtcgcc gtggccggca ttatttccta gttcttcttg   4800

taaccctgag gtgccagcgc ggggagtgag gaggggtcag ggggctaagg atgcaacctc   4860

tgacgttctg cgccttccta ggagagtctt acatgtgttg agatttcaca agcaatgcga   4920

gttgtaaaat accagctcta caagaagcta ggctctgtga cggcatagtt ttcagtagct   4980

ttatcacaat attcacaatg gagaattata tgacatggta gcagaaatag gcccttttat   5040

gtgttgcttc tattttacct caaattgtag atatagggta atcaataaaa tccatccatg   5100

cctttcacac actaagt                                                  5117


<210>  4773
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  4773

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
                485                 490                 495


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
            500                 505                 510


Phe Asn Leu Lys Phe Ala 
        515


<210>  4774
<211>  4246
<212>  DNA
<213>  Homo sapiens

<400>  4774
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   2040

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2100

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2160

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2220

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2280

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2340

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2400

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2460

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2520

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2580

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2640

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2700

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2760

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2820

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2880

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   2940

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   3000

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3060

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3120

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3180

ttcacggtca ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt   3240

gagtcagaag gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc   3300

acagaagaaa taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg   3360

tggtagacct cttccctcct aggagccttg agttacggtg tttattttcc aatcaagtga   3420

agatatctcc tacttctcct actggaacat ctcagcttct gcagtgaaga aaaattcctg   3480

tgatagttca gttctttagt ttttctattt gaaaaaaaaa aatcatttaa atgatccttt   3540

gttcacggct ctccttaatg actgagtgaa cagttcctat ctgtatattt gactaaacct   3600

tttcctaagc tatctctcat ggttcctatg tttttttatc ataattaaaa gcaaaaccat   3660

ctggatcacc taacagtcag aggtcagtat ctcagcgtgt gaattataga ggaaatacag   3720

agagaacctc ttccactttt acttttcgtc caaataaaat gcatggtgta ccagaagttg   3780

aagatcgggt tgaggattgg ggctagctcg atgacactaa ggccccaaca tcgcgggacc   3840

tgctgtggcg cggattctta ggaacgctgt tctagccggc cccctctcca ggggtcgccg   3900

tggccggcat tatttcctag ttcttcttgt aaccctgagg tgccagcgcg gggagtgagg   3960

aggggtcagg gggctaagga tgcaacctct gacgttctgc gccttcctag gagagtctta   4020

catgtgttga gatttcacaa gcaatgcgag ttgtaaaata ccagctctac aagaagctag   4080

gctctgtgac ggcatagttt tcagtagctt tatcacaata ttcacaatgg agaattatat   4140

gacatggtag cagaaatagg cccttttatg tgttgcttct attttacctc aaattgtaga   4200

tatagggtaa tcaataaaat ccatccatgc ctttcacaca ctaagt                  4246


<210>  4775
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  4775

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
    450                 455                 460


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
465                 470                 475


<210>  4776
<211>  4430
<212>  DNA
<213>  Homo sapiens

<400>  4776
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagc tcaagctctt ggactcaccg   2040

aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag   2100

gcttgccaga ggggattccc ttccgaagcc ctacctggtt tggaattcca cgacttgaaa   2160

ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt   2220

cctacttgcc tcctgggatg gctagtaaaa taaacactaa agctttgcag tcccccaaaa   2280

gaccacgaag tcctgggagt aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc   2340

ctaataacaa caatcctcaa acctcagctg ttcgaacccc gacccagact aacggttcta   2400

acgttccctt caagccacga gggagagagt tttcctttga ggcctggaat gccaaaatca   2460

cggacctaaa acagaaagtt gaaaatctct tcaatgagaa atgtggggaa gctcttggcc   2520

ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc tttcccggaa gacttttatg   2580

tggaaggctt acctgagggt gtgccattcc gaagaccatc gacttttggc attccgaggc   2640

tggagaagat actcagaaac aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt   2700

ttgagacggc gattaaggag agcacctcct ctaagagccc tcccagaaaa ataaattcat   2760

cacccaatgt taatactact gcatcaggtg ttgaagacct taacatcatt caggtgacaa   2820

ttccagatga tgataatgaa agactctcga aagttgaaaa agctagacag ctaagagaac   2880

aagtgaatga cctctttagt cggaaatttg gtgaagctat tggtatgggt tttcctgtga   2940

aagttcccta caggaaaatc acaattaacc ctggctgtgt ggtggttgat ggcatgcccc   3000

cgggggtgtc cttcaaagcc cccagctacc tggaaatcag ctccatgaga aggatcttag   3060

actctgccga gtttatcaaa ttcacggtca ttagaccatt tccaggactt gtgattaata   3120

accagctggt tgatcagagt gagtcagaag gccccgtgat acaagaatca gctgaaccaa   3180

gccagttgga agttccagcc acagaagaaa taaaagagac tgatggaagc tctcagatca   3240

agcaagaacc agaccccacg tggtagacct cttccctcct aggcttaaag tatcagtggt   3300

tgagaagagc ttttcggacc tgttactacc ccaagctgtg taatatactt gtataacaga   3360

aataccttct atacaaacct ttttttctac ttttagatag aaatgtctac tttttcagca   3420

gttctgtgaa ttaaagagca gagtgactgt gggtctggaa tggctggtgt acttgggaat   3480

gtactatcag gattttacag caatgctggg aaatgacagg gaaaatgaca ggaatgaatc   3540

tcaccagatt ttttatgtac tcagcagagc cttgagttac ggtgtttatt ttccaatcaa   3600

gtgaagatat ctcctacttc tcctactgga acatctcagc ttctgcagtg aagaaaaatt   3660

cctgtgatag ttcagttctt tagtttttct atttgaaaaa aaaaaatcat ttaaatgatc   3720

ctttgttcac ggctctcctt aatgactgag tgaacagttc ctatctgtat atttgactaa   3780

accttttcct aagctatctc tcatggttcc tatgtttttt tatcataatt aaaagcaaaa   3840

ccatctggat cacctaacag tcagaggtca gtatctcagc gtgtgaatta tagaggaaat   3900

acagagagaa cctcttccac ttttactttt cgtccaaata aaatgcatgg tgtaccagaa   3960

gttgaagatc gggttgagga ttggggctag ctcgatgaca ctaaggcccc aacatcgcgg   4020

gacctgctgt ggcgcggatt cttaggaacg ctgttctagc cggccccctc tccaggggtc   4080

gccgtggccg gcattatttc ctagttcttc ttgtaaccct gaggtgccag cgcggggagt   4140

gaggaggggt cagggggcta aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt   4200

cttacatgtg ttgagatttc acaagcaatg cgagttgtaa aataccagct ctacaagaag   4260

ctaggctctg tgacggcata gttttcagta gctttatcac aatattcaca atggagaatt   4320

atatgacatg gtagcagaaa taggcccttt tatgtgttgc ttctatttta cctcaaattg   4380

tagatatagg gtaatcaata aaatccatcc atgcctttca cacactaagt              4430


<210>  4777
<211>  954
<212>  PRT
<213>  Homo sapiens

<400>  4777

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly 
    530                 535                 540


Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro 
545                 550                 555                 560


Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser 
                565                 570                 575


Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser 
            580                 585                 590


Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr 
        595                 600                 605


Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser 
    610                 615                 620


Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile 
625                 630                 635                 640


Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala 
                645                 650                 655


Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro 
            660                 665                 670


Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp 
        675                 680                 685


Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala 
    690                 695                 700


Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser 
705                 710                 715                 720


Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe 
                725                 730                 735


Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg 
            740                 745                 750


Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu 
        755                 760                 765


Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile 
    770                 775                 780


Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu 
785                 790                 795                 800


Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser 
                805                 810                 815


Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe 
            820                 825                 830


Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val 
        835                 840                 845


Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly 
    850                 855                 860


Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser 
865                 870                 875                 880


Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val 
                885                 890                 895


Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln 
            900                 905                 910


Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln 
        915                 920                 925


Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser 
    930                 935                 940


Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  4778
<211>  3812
<212>  DNA
<213>  Homo sapiens

<400>  4778
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gtcaaagaag attggaatgt cagaattacc aagctacgga   1920

agcaagtgga agagattttt aatttgaaat ttgctcaagc tcttggactc accgaggcag   1980

taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgtatgtg gaaggcttgc   2040

cagaggggat tcccttccga agccctacct ggtttggaat tccacgactt gaaaggatcg   2100

tccgcgggag taataaaatc aagttcgttg ttaaaaaacc tgaactagtt atttcctact   2160

tgcctcctgg gatggctagt aaaataaaca ctaaagcttt gcagtccccc aaaagaccac   2220

gaagtcctgg gagtaattca aaggttcctg aaattgaggt caccgtggaa ggccctaata   2280

acaacaatcc tcaaacctca gctgttcgaa ccccgaccca gactaacggt tctaacgttc   2340

ccttcaagcc acgagggaga gagttttcct ttgaggcctg gaatgccaaa atcacggacc   2400

taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg ggaagctctt ggccttaaac   2460

aagctgtgaa ggtgccgttc gcgttatttg agtctttccc ggaagacttt tatgtggaag   2520

gcttacctga gggtgtgcca ttccgaagac catcgacttt tggcattccg aggctggaga   2580

agatactcag aaacaaagcc aaaattaagt tcatcattaa aaagcccgaa atgtttgaga   2640

cggcgattaa ggagagcacc tcctctaaga gccctcccag aaaaataaat tcatcaccca   2700

atgttaatac tactgcatca ggtgttgaag accttaacat cattcaggtg acaattccag   2760

atgatgataa tgaaagactc tcgaaagttg aaaaagctag acagctaaga gaacaagtga   2820

atgacctctt tagtcggaaa tttggtgaag ctattggtat gggttttcct gtgaaagttc   2880

cctacaggaa aatcacaatt aaccctggct gtgtggtggt tgatggcatg cccccggggg   2940

tgtccttcaa agcccccagc tacctggaaa tcagctccat gagaaggatc ttagactctg   3000

ccgagtttat caaattcacg gtcattagac catttccagg acttgtgatt aataaccagc   3060

tggttgatca gagtgagtca gaaggccccg tgatacaaga atcagctgaa ccaagccagt   3120

tggaagttcc agccacagaa gaaataaaag agactgatgg aagctctcag atcaagcaag   3180

aaccagaccc cacgtggtag acctcttccc tcctaggcaa aaccatctgg atcacctaac   3240

agtcagaggt cagtatctca gcgtgtgaat tatagaggaa atacagagag aacctcttcc   3300

acttttactt ttcgtccaaa taaaatgcat ggtgtaccag aagttgaaga tcgggttgag   3360

gattggggct agctcgatga cactaaggcc ccaacatcgc gggacctgct gtggcgcgga   3420

ttcttaggaa cgctgttcta gccggccccc tctccagggg tcgccgtggc cggcattatt   3480

tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc   3540

taaggatgca acctctgacg ttctgcgcct tcctaggaga gtcttacatg tgttgagatt   3600

tcacaagcaa tgcgagttgt aaaataccag ctctacaaga agctaggctc tgtgacggca   3660

tagttttcag tagctttatc acaatattca caatggagaa ttatatgaca tggtagcaga   3720

aataggccct tttatgtgtt gcttctattt tacctcaaat tgtagatata gggtaatcaa   3780

taaaatccat ccatgccttt cacacactaa gt                                 3812


<210>  4779
<211>  932
<212>  PRT
<213>  Homo sapiens

<400>  4779

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
                485                 490                 495


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
            500                 505                 510


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
        515                 520                 525


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu 
    530                 535                 540


Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile 
545                 550                 555                 560


Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val 
                565                 570                 575


Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala 
            580                 585                 590


Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser 
        595                 600                 605


Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly 
    610                 615                 620


Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln 
625                 630                 635                 640


Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser 
                645                 650                 655


Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu 
            660                 665                 670


Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala 
        675                 680                 685


Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr 
    690                 695                 700


Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe 
705                 710                 715                 720


Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys 
                725                 730                 735


Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser 
            740                 745                 750


Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val 
        755                 760                 765


Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr 
    770                 775                 780


Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg 
785                 790                 795                 800


Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu 
                805                 810                 815


Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr 
            820                 825                 830


Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser 
        835                 840                 845


Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu 
    850                 855                 860


Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly 
865                 870                 875                 880


Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro 
                885                 890                 895


Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr 
            900                 905                 910


Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro 
        915                 920                 925


Asp Pro Thr Trp 
    930


<210>  4780
<211>  5127
<212>  DNA
<213>  Homo sapiens

<400>  4780
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   2040

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2100

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2160

tgaaaggatc gtccgcggga gtaataaaat caagttcgtt gttaaaaaac ctgaactagt   2220

tatttcctac ttgcctcctg ggatggctag taaaataaac actaaagctt tgcagtcccc   2280

caaaagacca cgaagtcctg ggagtaattc aaaggttcct gaaattgagg tcaccgtgga   2340

aggccctaat aacaacaatc ctcaaacctc agctgttcga accccgaccc agactaacgg   2400

ttctaacgtt cccttcaagc cacgagggag agagttttcc tttgaggcct ggaatgccaa   2460

aatcacggac ctaaaacaga aagttgaaaa tctcttcaat gagaaatgtg gggaagctct   2520

tggccttaaa caagctgtga aggtgccgtt cgcgttattt gagtctttcc cggaagactt   2580

ttatgtggaa ggcttacctg agggtgtgcc attccgaaga ccatcgactt ttggcattcc   2640

gaggctggag aagatactca gaaacaaagc caaaattaag ttcatcatta aaaagcccga   2700

aatgtttgag acggcgatta aggagagcac ctcctctaag agccctccca gaaaaataaa   2760

ttcatcaccc aatgttaata ctactgcatc aggtgttgaa gaccttaaca tcattcaggt   2820

gacaattcca gatgatgata atgaaagact ctcgaaagtt gaaaaagcta gacagctaag   2880

agaacaagtg aatgacctct ttagtcggaa atttggtgaa gctattggta tgggttttcc   2940

tgtgaaagtt ccctacagga aaatcacaat taaccctggc tgtgtggtgg ttgatggcat   3000

gcccccgggg gtgtccttca aagcccccag ctacctggaa atcagctcca tgagaaggat   3060

cttagactct gccgagttta tcaaattcac ggtcattaga ccatttccag gacttgtgat   3120

taataaccag ctggttgatc agagtgagtc agaaggcccc gtgatacaag aatcagctga   3180

accaagccag ttggaagttc cagccacaga agaaataaaa gagactgatg gaagctctca   3240

gatcaagcaa gaaccagacc ccacgtggta gacctcttcc ctcctagggt aaatcagctt   3300

ctgtgtcagg gatgctgtgt ggtgtccatc tgaaccccct gcatacgcgt agctaatgtg   3360

atctccccac tttcacataa gatggtggcc ctgccttcag ggaatgtggg agccaggtgg   3420

gagccttccc ggatatttaa gctagaagat tctacaggga gattctcctt ggatcaatat   3480

atgtctctca gtcaaagatg taaaagcact tttgccttaa aaagaatgtt ctgtttctaa   3540

atagagtcaa cgttgtcctc ctcattggaa ttcactatga gtcagaatca ttagactgac   3600

tttttttttt ccatagtaat agtattttgc agagtctcac agagctgcag atcttttgtt   3660

catcttgcag agttaacaag tctgatcctg ttagtccaga tttcttaaat ttggccaagt   3720

tataatagga gcagtagctt gagacccgaa gtcaggaaac tttgacaatg gatttttttt   3780

tttaatccag agacttgtac tggaatttgc cttaccctgt cagctcatgg acttaaggtt   3840

tcatcccgct ttatgagtgc ttctgaatcc aagtcattgt tacctgaatt tgcaaattaa   3900

gttgtgatat tcgtgactgt taaattcctg taattagatt aacctctttg cttgcttgtt   3960

tgttttctct cctattttag cttaaagtat cagtggttga gaagagcttt tcggacctgt   4020

tactacccca agctgtgtaa tatacttgta taacagaaat accttctata caaacctttt   4080

tttctacttt tagatagaaa tgtctacttt ttcagcagtt ctgtgaatta aagagcagag   4140

tgactgtggg tctggaatgg ctggtgtact tgggaatgta ctatcaggat tttacagcaa   4200

tgctgggaaa tgacagggaa aatgacagga atgaatctca ccagattttt tatgtactca   4260

gcagagcctt gagttacggt gtttattttc caatcaagtg aagatatctc ctacttctcc   4320

tactggaaca tctcagcttc tgcagtgaag aaaaattcct gtgatagttc agttctttag   4380

tttttctatt tgaaaaaaaa aaatcattta aatgatcctt tgttcacggc tctccttaat   4440

gactgagtga acagttccta tctgtatatt tgactaaacc ttttcctaag ctatctctca   4500

tggttcctat gtttttttat cataattaaa agcaaaacca tctggatcac ctaacagtca   4560

gaggtcagta tctcagcgtg tgaattatag aggaaataca gagagaacct cttccacttt   4620

tacttttcgt ccaaataaaa tgcatggtgt accagaagtt gaagatcggg ttgaggattg   4680

gggctagctc gatgacacta aggccccaac atcgcgggac ctgctgtggc gcggattctt   4740

aggaacgctg ttctagccgg ccccctctcc aggggtcgcc gtggccggca ttatttccta   4800

gttcttcttg taaccctgag gtgccagcgc ggggagtgag gaggggtcag ggggctaagg   4860

atgcaacctc tgacgttctg cgccttccta ggagagtctt acatgtgttg agatttcaca   4920

agcaatgcga gttgtaaaat accagctcta caagaagcta ggctctgtga cggcatagtt   4980

ttcagtagct ttatcacaat attcacaatg gagaattata tgacatggta gcagaaatag   5040

gcccttttat gtgttgcttc tattttacct caaattgtag atatagggta atcaataaaa   5100

tccatccatg cctttcacac actaagt                                       5127


<210>  4781
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  4781

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala 
            580                 585                 590


Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600                 605


<210>  4782
<211>  7280
<212>  DNA
<213>  Homo sapiens

<400>  4782
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   2040

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2100

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2160

atcaaacccg gagttcttgt atgtggaagg cttgccagag gggattccct tccgaagccc   2220

tacctggttt ggaattccac gacttgaaag gatcgtccgc gggagtaata aaatcaagtt   2280

cgttgttaaa aaacctgaac tagttatttc ctacttgcct cctgggatgg ctagtaaaat   2340

aaacactaaa gctttgcagt cccccaaaag accacgaagt cctgggagta attcaaaggt   2400

tcctgaaatt gaggtcaccg tggaaggccc taataacaac aatcctcaaa cctcagctgt   2460

tcgaaccccg acccagacta acggttctaa cgttcccttc aagccacgag ggagagagtt   2520

ttcctttgag gcctggaatg ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt   2580

caatgagaaa tgtggggaag ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt   2640

atttgagtct ttcccggaag acttttatgt ggaaggctta cctgagggtg tgccattccg   2700

aagaccatcg acttttggca ttccgaggct ggagaagata ctcagaaaca aagccaaaat   2760

taagttcatc attaaaaagc ccgaaatgtt tgagacggcg attaaggaga gcacctcctc   2820

taagagccct cccagaaaaa taaattcatc acccaatgtt aatactactg catcaggtgt   2880

tgaagacctt aacatcattc aggtgacaat tccagatgat gataatgaaa gactctcgaa   2940

agttgaaaaa gctagacagc taagagaaca agtgaatgac ctctttagtc ggaaatttgg   3000

tgaagctatt ggtatgggtt ttcctgtgaa agttccctac aggaaaatca caattaaccc   3060

tggctgtgtg gtggttgatg gcatgccccc gggggtgtcc ttcaaagccc ccagctacct   3120

ggaaatcagc tccatgagaa ggatcttaga ctctgccgag tttatcaaat tcacggtcat   3180

taggtaagtg agagtttcct gcttagtcac aggagcgaat ctggagctca tgaggctgac   3240

tcttctaaaa tgcagccaca ggtagtcatc gaatccggct tcctatgctg tgcaatcaac   3300

aaatcaaaat aacttgtgtc atcattagaa tgtcagatgt gcttctacga actaagctga   3360

ctcttttaat tctttggcaa agggttggca aactaggact gtttgccaaa ttcaggctgc   3420

ctcctatttt tagagtcttc ctgaaacaca gctacacccg tattatccat ggctgctttc   3480

ctgtcacagt gagtaagtag ctgggactga gaaggcatgg cctccaaagt ctaaaatatt   3540

tactctctag cactttgtag aaaaacctta gctaggcaca gtggctaacg cctgtaatcc   3600

cagcattttg ggaggccaag gcaggcagat cacctgaggt caggagttcc agaccagcct   3660

ggccaacatg gtgaaatccc atctctacaa aaataaaaca gttagctggg catgatggcg   3720

ggtgcctgta atcccagcta ctcgggaggc tgaggcagga tagtcgcttg aacccaggag   3780

gtggaggttg caatgagcca agatcatgcc actgcactcc agcctggacg acagagtgag   3840

actccatcac aagaaaaaaa gaactttgtc aacctctgtc ttagggcgcc ttgtcacagg   3900

cttcgggtca gacggattca accttgcatc agccatttgt tagccaggtc actctgttct   3960

ttgtctgtaa atgagattga tcgttgttcc cactgagagt gtcagctcct tcccgtagag   4020

caggcatgat gattgtactc acctctgaca ccattgtgag tgccacattc cttcccacgt   4080

ccttgtcact gtaagagatg cccacctgag caccaacccc aggttatctt cccctttgtc   4140

ttccagcccc ccagaaacag ctacgactca acctacccaa tcatttcatc atcagattgc   4200

cactgtctct agttcaggtc tcttgggact ggcactcaga aatctcataa taaatcctct   4260

tgaggcttct catacactcg tcttcttcca atcttctttc cctcaaaatc tcatattttg   4320

gttccacttc acccaccgtc attctccata tcactcccag gagttaggca aaaagcccct   4380

tccgttcttc cgtatgttaa acttagaatc actctgttcc ctgctctgcg tttctatttt   4440

ttgtttttcc tccatttact agtagcttaa cactttctaa cagtgttctt attattgata   4500

cgtatctatc tcttccataa gcttataagg tcacggataa tacttctcat tgtagtacgt   4560

aaatgacgtg ggctagatat gagttgaata aacagttata cctgtaaatt cttacagagt   4620

gaaaataaat tgttatactt tacaatttgt ttctctcttt agaccatttc caggacttgt   4680

gattaataac cgtgagtatt ttgtgaagtg ttttgttttt gttttttcct ggggtctgac   4740

gtgtgtgcgt gtgagtgtgt atacatgctt aacgtatatc acgttacttc acctatgtca   4800

gtaaccaggc caaatacttg ttttagccct cagtaaaaac accaggcact tcctagttgt   4860

aaaattattc aagcttctta acttcctatc ctcgatgcac ttaatcataa aatggtaata   4920

atagcaccga ttttggggga gtcgttccag tagatggaaa gcatctggaa caggtgtcag   4980

caagctcctg ccgacgtgta tgcataaagt tttattgaaa ccaccatcgt gtccatttgt   5040

ttatggcaga actgagagat ggcagcagca agtgtgtgcc tgcaaaacct aaaatattta   5100

ctaattggct ctgcaagaaa agagtttgca tccccctaac ctagaacagt gtctagcctc   5160

tagtatgtgt ttagcctaca gtatgtgctc agcgaataca atctatattt attactgctt   5220

ttatgactgt tataattact gtgcttggat ttcgttacaa agtaagtcac aatgtgcctg   5280

cttctgttag tatttcagca cagtgcctgg cacacatggg gctctcaaat attgctgagc   5340

gagtgaacaa atgtcctttc aattccttaa cgttgatgtc attttcaata gtattttgag   5400

ccaaacttaa ttttgcgagt gtgttttgtt ttcttaactt tattattaaa aatgtataaa   5460

agtgaggcca ggcgtggtgg ctcacgcctg taatcccagc agtttgggag gctgaggcag   5520

gcggatcagt tgaggttggg agttggagac cagcccgtcc aacatggtga aagcctgtct   5580

ctactaaaaa tacaaaaatc agctgggtgt ggtggcgcgt gcctgtaatc ccagctactc   5640

aggaggctga ggcaggagag ttgcttgaat cctagaggtg gaggttgcag tgagctgaga   5700

tcgtgccatt gcactccagc ctgggcaaca agagcaaaac tctgtcccaa taaataaata   5760

aataaaatgt tctcttttgt tcctgttctt gtgcggtagt gtggtataga gttttatggt   5820

aattactgtg aattagtgat tctgagggac atatcagaac tctgaggttt gtttccttct   5880

catcttgagg gaaacagcaa atgtatgtta aaatgctttt ccaagggaac aacacatcct   5940

tacattattt aaaccaatct gcttcatttt cagagctggt tgatcagagt gagtcagaag   6000

gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc acagaagaaa   6060

taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg tggtagacct   6120

cttccctcct aggcttaaag tatcagtggt tgagaagagc ttttcggacc tgttactacc   6180

ccaagctgtg taatatactt gtataacaga aataccttct atacaaacct ttttttctac   6240

ttttagatag aaatgtctac tttttcagca gttctgtgaa ttaaagagca gagtgactgt   6300

gggtctggaa tggctggtgt acttgggaat gtactatcag gattttacag caatgctggg   6360

aaatgacagg gaaaatgaca ggaatgaatc tcaccagatt ttttatgtac tcagcagagc   6420

cttgagttac ggtgtttatt ttccaatcaa gtgaagatat ctcctacttc tcctactgga   6480

acatctcagc ttctgcagtg aagaaaaatt cctgtgatag ttcagttctt tagtttttct   6540

atttgaaaaa aaaaaatcat ttaaatgatc ctttgttcac ggctctcctt aatgactgag   6600

tgaacagttc ctatctgtat atttgactaa accttttcct aagctatctc tcatggttcc   6660

tatgtttttt tatcataatt aaaagcaaaa ccatctggat cacctaacag tcagaggtca   6720

gtatctcagc gtgtgaatta tagaggaaat acagagagaa cctcttccac ttttactttt   6780

cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc gggttgagga ttggggctag   6840

ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg   6900

ctgttctagc cggccccctc tccaggggtc gccgtggccg gcattatttc ctagttcttc   6960

ttgtaaccct gaggtgccag cgcggggagt gaggaggggt cagggggcta aggatgcaac   7020

ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg ttgagatttc acaagcaatg   7080

cgagttgtaa aataccagct ctacaagaag ctaggctctg tgacggcata gttttcagta   7140

gctttatcac aatattcaca atggagaatt atatgacatg gtagcagaaa taggcccttt   7200

tatgtgttgc ttctatttta cctcaaattg tagatatagg gtaatcaata aaatccatcc   7260

atgcctttca cacactaagt                                               7280


<210>  4783
<211>  921
<212>  PRT
<213>  Homo sapiens

<400>  4783

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
                565                 570                 575


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
            580                 585                 590


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
        595                 600                 605


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
    610                 615                 620


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
625                 630                 635                 640


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
                645                 650                 655


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
            660                 665                 670


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
        675                 680                 685


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
    690                 695                 700


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
705                 710                 715                 720


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
                725                 730                 735


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
            740                 745                 750


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
        755                 760                 765


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
    770                 775                 780


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
785                 790                 795                 800


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
                805                 810                 815


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
            820                 825                 830


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
        835                 840                 845


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
    850                 855                 860


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
865                 870                 875                 880


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
                885                 890                 895


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
            900                 905                 910


Glu Phe Ile Lys Phe Thr Val Ile Arg 
        915                 920


<210>  4784
<211>  5103
<212>  DNA
<213>  Homo sapiens

<400>  4784
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   2040

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2100

taccatatcc tgtgtttgaa tcaaacccgg agttcttgaa aggatcgtcc gcgggagtaa   2160

taaaatcaag ttcgttgtta aaaaacctga actagttatt tcctacttgc ctcctgggat   2220

ggctagtaaa ataaacacta aagctttgca gtcccccaaa agaccacgaa gtcctgggag   2280

taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc cctaataaca acaatcctca   2340

aacctcagct gttcgaaccc cgacccagac taacggttct aacgttccct tcaagccacg   2400

agggagagag ttttcctttg aggcctggaa tgccaaaatc acggacctaa aacagaaagt   2460

tgaaaatctc ttcaatgaga aatgtgggga agctcttggc cttaaacaag ctgtgaaggt   2520

gccgttcgcg ttatttgagt ctttcccgga agacttttat gtggaaggct tacctgaggg   2580

tgtgccattc cgaagaccat cgacttttgg cattccgagg ctggagaaga tactcagaaa   2640

caaagccaaa attaagttca tcattaaaaa gcccgaaatg tttgagacgg cgattaagga   2700

gagcacctcc tctaagagcc ctcccagaaa aataaattca tcacccaatg ttaatactac   2760

tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca attccagatg atgataatga   2820

aagactctcg aaagttgaaa aagctagaca gctaagagaa caagtgaatg acctctttag   2880

tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg aaagttccct acaggaaaat   2940

cacaattaac cctggctgtg tggtggttga tggcatgccc ccgggggtgt ccttcaaagc   3000

ccccagctac ctggaaatca gctccatgag aaggatctta gactctgccg agtttatcaa   3060

attcacggtc attagaccat ttccaggact tgtgattaat aaccagctgg ttgatcagag   3120

tgagtcagaa ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc   3180

cacagaagaa ataaaagaga ctgatggaag ctctcagatc aagcaagaac cagaccccac   3240

gtggtagacc tcttccctcc tagggtaaat cagcttctgt gtcagggatg ctgtgtggtg   3300

tccatctgaa ccccctgcat acgcgtagct aatgtgatct ccccactttc acataagatg   3360

gtggccctgc cttcagggaa tgtgggagcc aggtgggagc cttcccggat atttaagcta   3420

gaagattcta cagggagatt ctccttggat caatatatgt ctctcagtca aagatgtaaa   3480

agcacttttg ccttaaaaag aatgttctgt ttctaaatag agtcaacgtt gtcctcctca   3540

ttggaattca ctatgagtca gaatcattag actgactttt ttttttccat agtaatagta   3600

ttttgcagag tctcacagag ctgcagatct tttgttcatc ttgcagagtt aacaagtctg   3660

atcctgttag tccagatttc ttaaatttgg ccaagttata ataggagcag tagcttgaga   3720

cccgaagtca ggaaactttg acaatggatt ttttttttta atccagagac ttgtactgga   3780

atttgcctta ccctgtcagc tcatggactt aaggtttcat cccgctttat gagtgcttct   3840

gaatccaagt cattgttacc tgaatttgca aattaagttg tgatattcgt gactgttaaa   3900

ttcctgtaat tagattaacc tctttgcttg cttgtttgtt ttctctccta ttttagctta   3960

aagtatcagt ggttgagaag agcttttcgg acctgttact accccaagct gtgtaatata   4020

cttgtataac agaaatacct tctatacaaa cctttttttc tacttttaga tagaaatgtc   4080

tactttttca gcagttctgt gaattaaaga gcagagtgac tgtgggtctg gaatggctgg   4140

tgtacttggg aatgtactat caggatttta cagcaatgct gggaaatgac agggaaaatg   4200

acaggaatga atctcaccag attttttatg tactcagcag agccttgagt tacggtgttt   4260

attttccaat caagtgaaga tatctcctac ttctcctact ggaacatctc agcttctgca   4320

gtgaagaaaa attcctgtga tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat   4380

catttaaatg atcctttgtt cacggctctc cttaatgact gagtgaacag ttcctatctg   4440

tatatttgac taaacctttt cctaagctat ctctcatggt tcctatgttt ttttatcata   4500

attaaaagca aaaccatctg gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa   4560

ttatagagga aatacagaga gaacctcttc cacttttact tttcgtccaa ataaaatgca   4620

tggtgtacca gaagttgaag atcgggttga ggattggggc tagctcgatg acactaaggc   4680

cccaacatcg cgggacctgc tgtggcgcgg attcttagga acgctgttct agccggcccc   4740

ctctccaggg gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac cctgaggtgc   4800

cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc   4860

ttcctaggag agtcttacat gtgttgagat ttcacaagca atgcgagttg taaaatacca   4920

gctctacaag aagctaggct ctgtgacggc atagttttca gtagctttat cacaatattc   4980

acaatggaga attatatgac atggtagcag aaataggccc ttttatgtgt tgcttctatt   5040

ttacctcaaa ttgtagatat agggtaatca ataaaatcca tccatgcctt tcacacacta   5100

agt                                                                 5103


<210>  4785
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  4785

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
465                 470                 475                 480


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
                485                 490                 495


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
            500                 505                 510


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
        515                 520                 525


Ser Ser Leu Leu Lys Asn Leu Asn 
    530                 535


<210>  4786
<211>  4948
<212>  DNA
<213>  Homo sapiens

<400>  4786
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagctca agctcttgga ctcaccgagg   1920

cagtaaaagt accatatcct gtgtttgaat caaacccgga gttcttgtat gtggaaggct   1980

tgccagaggg gattcccttc cgaagcccta cctggtttgg aattccacga cttgaaagga   2040

tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa acctgaacta gttatttcct   2100

acttgcctcc tgggatggct agtaaaataa acactaaagc tttgcagtcc cccaaaagac   2160

cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta   2220

ataacaacaa tcctcaaacc tcagctgttc gaaccccgac ccagactaac ggttctaacg   2280

ttcccttcaa gccacgaggg agagagtttt cctttgaggc ctggaatgcc aaaatcacgg   2340

acctaaaaca gaaagttgaa aatctcttca atgagaaatg tggggaagct cttggcctta   2400

aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg   2460

aaggcttacc tgagggtgtg ccattccgaa gaccatcgac ttttggcatt ccgaggctgg   2520

agaagatact cagaaacaaa gccaaaatta agttcatcat taaaaagccc gaaatgtttg   2580

agacggcgat taaggagagc acctcctcta agagccctcc cagaaaaata aattcatcac   2640

ccaatgttaa tactactgca tcaggtgttg aagaccttaa catcattcag gtgacaattc   2700

cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta agagaacaag   2760

tgaatgacct ctttagtcgg aaatttggtg aagctattgg tatgggtttt cctgtgaaag   2820

ttccctacag gaaaatcaca attaaccctg gctgtgtggt ggttgatggc atgcccccgg   2880

gggtgtcctt caaagccccc agctacctgg aaatcagctc catgagaagg atcttagact   2940

ctgccgagtt tatcaaattc acggtcatta gaccatttcc aggacttgtg attaataacc   3000

agctggttga tcagagtgag tcagaaggcc ccgtgataca agaatcagct gaaccaagcc   3060

agttggaagt tccagccaca gaaggtaaaa ggacctcttc cctcctaggg taaatcagct   3120

tctgtgtcag ggatgctgtg tggtgtccat ctgaaccccc tgcatacgcg tagctaatgt   3180

gatctcccca ctttcacata agatggtggc cctgccttca gggaatgtgg gagccaggtg   3240

ggagccttcc cggatattta agctagaaga ttctacaggg agattctcct tggatcaata   3300

tatgtctctc agtcaaagat gtaaaagcac ttttgcctta aaaagaatgt tctgtttcta   3360

aatagagtca acgttgtcct cctcattgga attcactatg agtcagaatc attagactga   3420

cttttttttt tccatagtaa tagtattttg cagagtctca cagagctgca gatcttttgt   3480

tcatcttgca gagttaacaa gtctgatcct gttagtccag atttcttaaa tttggccaag   3540

ttataatagg agcagtagct tgagacccga agtcaggaaa ctttgacaat ggattttttt   3600

ttttaatcca gagacttgta ctggaatttg ccttaccctg tcagctcatg gacttaaggt   3660

ttcatcccgc tttatgagtg cttctgaatc caagtcattg ttacctgaat ttgcaaatta   3720

agttgtgata ttcgtgactg ttaaattcct gtaattagat taacctcttt gcttgcttgt   3780

ttgttttctc tcctatttta gcttaaagta tcagtggttg agaagagctt ttcggacctg   3840

ttactacccc aagctgtgta atatacttgt ataacagaaa taccttctat acaaaccttt   3900

ttttctactt ttagatagaa atgtctactt tttcagcagt tctgtgaatt aaagagcaga   3960

gtgactgtgg gtctggaatg gctggtgtac ttgggaatgt actatcagga ttttacagca   4020

atgctgggaa atgacaggga aaatgacagg aatgaatctc accagatttt ttatgtactc   4080

agcagagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct cctacttctc   4140

ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta   4200

gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg ctctccttaa   4260

tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa gctatctctc   4320

atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca cctaacagtc   4380

agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc tcttccactt   4440

ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg gttgaggatt   4500

ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg cgcggattct   4560

taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc attatttcct   4620

agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca gggggctaag   4680

gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt gagatttcac   4740

aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg acggcatagt   4800

tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt agcagaaata   4860

ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt aatcaataaa   4920

atccatccat gcctttcaca cactaagt                                      4948


<210>  4787
<211>  903
<212>  PRT
<213>  Homo sapiens

<400>  4787

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
            500                 505                 510


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
        515                 520                 525


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
    530                 535                 540


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
545                 550                 555                 560


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
                565                 570                 575


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
            580                 585                 590


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
        595                 600                 605


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
    610                 615                 620


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
625                 630                 635                 640


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
                645                 650                 655


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
            660                 665                 670


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
        675                 680                 685


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
    690                 695                 700


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
705                 710                 715                 720


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
                725                 730                 735


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
            740                 745                 750


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
        755                 760                 765


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
    770                 775                 780


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
785                 790                 795                 800


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
                805                 810                 815


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
            820                 825                 830


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
        835                 840                 845


Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile 
    850                 855                 860


Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln 
865                 870                 875                 880


Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Gly Lys 
                885                 890                 895


Arg Thr Ser Ser Leu Leu Gly 
            900


<210>  4788
<211>  3820
<212>  DNA
<213>  Homo sapiens

<400>  4788
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gctcaagctc ttggactcac   1980

cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct tgtatgtgga   2040

aggcttgcca gaggggattc ccttccgaag ccctacctgg tttggaattc cacgacttga   2100

aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg aactagttat   2160

ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc agtcccccaa   2220

aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg   2280

ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga ctaacggttc   2340

taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga atgccaaaat   2400

cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg   2460

ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg aagactttta   2520

tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg gcattccgag   2580

gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa agcccgaaat   2640

gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa aaataaattc   2700

atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca ttcaggtgac   2760

aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac agctaagaga   2820

acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg gttttcctgt   2880

gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg atggcatgcc   2940

cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga gaaggatctt   3000

agactctgcc gagtttatca aattcacggt cattagacca tttccaggac ttgtgattaa   3060

taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat cagctgaacc   3120

aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa gctctcagat   3180

caagcaagaa ccagacccca cgtggtagac ctcttccctc ctaggcaaaa ccatctggat   3240

cacctaacag tcagaggtca gtatctcagc gtgtgaatta tagaggaaat acagagagaa   3300

cctcttccac ttttactttt cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc   3360

gggttgagga ttggggctag ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt   3420

ggcgcggatt cttaggaacg ctgttctagc cggccccctc tccaggggtc gccgtggccg   3480

gcattatttc ctagttcttc ttgtaaccct gaggtgccag cgcggggagt gaggaggggt   3540

cagggggcta aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg   3600

ttgagatttc acaagcaatg cgagttgtaa aataccagct ctacaagaag ctaggctctg   3660

tgacggcata gttttcagta gctttatcac aatattcaca atggagaatt atatgacatg   3720

gtagcagaaa taggcccttt tatgtgttgc ttctatttta cctcaaattg tagatatagg   3780

gtaatcaata aaatccatcc atgcctttca cacactaagt                         3820


<210>  4789
<211>  928
<212>  PRT
<213>  Homo sapiens

<400>  4789

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro 
        515                 520                 525


Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu 
    530                 535                 540


Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu 
545                 550                 555                 560


Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro 
                565                 570                 575


Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn 
            580                 585                 590


Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn 
        595                 600                 605


Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn 
    610                 615                 620


Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser 
625                 630                 635                 640


Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp 
                645                 650                 655


Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn 
            660                 665                 670


Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro 
        675                 680                 685


Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu 
    690                 695                 700


Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg 
705                 710                 715                 720


Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys 
                725                 730                 735


Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys 
            740                 745                 750


Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala 
        755                 760                 765


Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp 
    770                 775                 780


Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu 
785                 790                 795                 800


Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met 
                805                 810                 815


Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly 
            820                 825                 830


Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro 
        835                 840                 845


Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu 
    850                 855                 860


Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn 
865                 870                 875                 880


Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu 
                885                 890                 895


Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys 
            900                 905                 910


Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
        915                 920                 925


<210>  4790
<211>  4307
<212>  DNA
<213>  Homo sapiens

<400>  4790
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagctca agctcttgga ctcaccgagg   1920

cagtaaaagt accatatcct gtgtttgaat caaacccgga gttcttgtat gtggaaggct   1980

tgccagaggg gattcccttc cgaagcccta cctggtttgg aattccacga cttgaaagga   2040

tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa acctgaacta gttatttcct   2100

acttgcctcc tgggatggct agtaaaataa acactaaagc tttgcagtcc cccaaaagac   2160

cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta   2220

ataacaacaa tcctcaaacc tcagctgttc gaaccccgac ccagactaac ggttctaacg   2280

ttcccttcaa gccacgaggg agagagtttt cctttgaggc ctggaatgcc aaaatcacgg   2340

acctaaaaca gaaagttgaa aatctcttca atgagaaatg tggggaagct cttggcctta   2400

aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg   2460

aaggcttacc tgagggtgtg ccattccgaa gaccatcgac ttttggcatt ccgaggctgg   2520

agaagatact cagaaacaaa gccaaaatta agttcatcat taaaaagccc gaaatgtttg   2580

agacggcgat taaggagagc acctcctcta agagccctcc cagaaaaata aattcatcac   2640

ccaatgttaa tactactgca tcaggtgttg aagaccttaa catcattcag gtgacaattc   2700

cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta agagaacaag   2760

tgaatgacct ctttagtcgg aaatttggtg aagctattgg tatgggtttt cctgtgaaag   2820

ttccctacag gaaaatcaca attaaccctg gctgtgtggt ggttgatggc atgcccccgg   2880

gggtgtcctt caaagccccc agctacctgg aaatcagctc catgagaagg atcttagact   2940

ctgccgagtt tatcaaattc acggtcatta gaccatttcc aggacttgtg attaataacc   3000

agctggttga tcagagtgag tcagaaggcc ccgtgataca agaatcagct gaaccaagcc   3060

agttggaagt tccagccaca gaagaaataa aagagactga tggaagctct cagatcaagc   3120

aagaaccaga ccccacgtgg tagacctctt ccctcctagg cttaaagtat cagtggttga   3180

gaagagcttt tcggacctgt tactacccca agctgtgtaa tatacttgta taacagaaat   3240

accttctata caaacctttt tttctacttt tagatagaaa tgtctacttt ttcagcagtt   3300

ctgtgaatta aagagcagag tgactgtggg tctggaatgg ctggtgtact tgggaatgta   3360

ctatcaggat tttacagcaa tgctgggaaa tgacagggaa aatgacagga atgaatctca   3420

ccagattttt tatgtactca gcagagcctt gagttacggt gtttattttc caatcaagtg   3480

aagatatctc ctacttctcc tactggaaca tctcagcttc tgcagtgaag aaaaattcct   3540

gtgatagttc agttctttag tttttctatt tgaaaaaaaa aaatcattta aatgatcctt   3600

tgttcacggc tctccttaat gactgagtga acagttccta tctgtatatt tgactaaacc   3660

ttttcctaag ctatctctca tggttcctat gtttttttat cataattaaa agcaaaacca   3720

tctggatcac ctaacagtca gaggtcagta tctcagcgtg tgaattatag aggaaataca   3780

gagagaacct cttccacttt tacttttcgt ccaaataaaa tgcatggtgt accagaagtt   3840

gaagatcggg ttgaggattg gggctagctc gatgacacta aggccccaac atcgcgggac   3900

ctgctgtggc gcggattctt aggaacgctg ttctagccgg ccccctctcc aggggtcgcc   3960

gtggccggca ttatttccta gttcttcttg taaccctgag gtgccagcgc ggggagtgag   4020

gaggggtcag ggggctaagg atgcaacctc tgacgttctg cgccttccta ggagagtctt   4080

acatgtgttg agatttcaca agcaatgcga gttgtaaaat accagctcta caagaagcta   4140

ggctctgtga cggcatagtt ttcagtagct ttatcacaat attcacaatg gagaattata   4200

tgacatggta gcagaaatag gcccttttat gtgttgcttc tattttacct caaattgtag   4260

atatagggta atcaataaaa tccatccatg cctttcacac actaagt                 4307


<210>  4791
<211>  913
<212>  PRT
<213>  Homo sapiens

<400>  4791

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
            500                 505                 510


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
        515                 520                 525


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
    530                 535                 540


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
545                 550                 555                 560


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
                565                 570                 575


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
            580                 585                 590


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
        595                 600                 605


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
    610                 615                 620


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
625                 630                 635                 640


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
                645                 650                 655


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
            660                 665                 670


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
        675                 680                 685


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
    690                 695                 700


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
705                 710                 715                 720


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
                725                 730                 735


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
            740                 745                 750


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
        755                 760                 765


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
    770                 775                 780


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
785                 790                 795                 800


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
                805                 810                 815


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
            820                 825                 830


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
        835                 840                 845


Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile 
    850                 855                 860


Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln 
865                 870                 875                 880


Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile 
                885                 890                 895


Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr 
            900                 905                 910


Trp 



<210>  4792
<211>  4086
<212>  DNA
<213>  Homo sapiens

<400>  4792
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagc tcaagctctt ggactcaccg   1980

aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag   2040

gcttgccaga ggggattccc ttccgaagcc ctacctggtt tggaattcca cgacttgaaa   2100

ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt   2160

cctacttgcc tcctgggatg gctagtaaaa taaacactaa agctttgcag tcccccaaaa   2220

gaccacgaag tcctgggagt aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc   2280

ctaataacaa caatcctcaa acctcagctg ttcgaacccc gacccagact aacggttcta   2340

acgttccctt caagccacga gggagagagt tttcctttga ggcctggaat gccaaaatca   2400

cggacctaaa acagaaagtt gaaaatctct tcaatgagaa atgtggggaa gctcttggcc   2460

ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc tttcccggaa gacttttatg   2520

tggaaggctt acctgagggt gtgccattcc gaagaccatc gacttttggc attccgaggc   2580

tggagaagat actcagaaac aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt   2640

ttgagacggc gattaaggag agcacctcct ctaagagccc tcccagaaaa ataaattcat   2700

cacccaatgt taatactact gcatcaggtg ttgaagacct taacatcatt caggtgacaa   2760

ttccagatga tgataatgaa agactctcga aagttgaaaa agctagacag ctaagagaac   2820

aagtgaatga cctctttagt cggaaatttg gtgaagctat tggtatgggt tttcctgtga   2880

aagttcccta caggaaaatc acaattaacc ctggctgtgt ggtggttgat ggcatgcccc   2940

cgggggtgtc cttcaaagcc cccagctacc tggaaatcag ctccatgaga aggatcttag   3000

actctgccga gtttatcaaa ttcacggtca ttagaccatt tccaggactt gtgattaata   3060

accagctggt tgatcagagt gagtcagaag gccccgtgat acaagaatca gctgaaccaa   3120

gccagttgga agttccagcc acagaagaaa taaaagagac tgatggaagc tctcagatca   3180

agcaagaacc agaccccacg tggtagacct cttccctcct aggagccttg agttacggtg   3240

tttattttcc aatcaagtga agatatctcc tacttctcct actggaacat ctcagcttct   3300

gcagtgaaga aaaattcctg tgatagttca gttctttagt ttttctattt gaaaaaaaaa   3360

aatcatttaa atgatccttt gttcacggct ctccttaatg actgagtgaa cagttcctat   3420

ctgtatattt gactaaacct tttcctaagc tatctctcat ggttcctatg tttttttatc   3480

ataattaaaa gcaaaaccat ctggatcacc taacagtcag aggtcagtat ctcagcgtgt   3540

gaattataga ggaaatacag agagaacctc ttccactttt acttttcgtc caaataaaat   3600

gcatggtgta ccagaagttg aagatcgggt tgaggattgg ggctagctcg atgacactaa   3660

ggccccaaca tcgcgggacc tgctgtggcg cggattctta ggaacgctgt tctagccggc   3720

cccctctcca ggggtcgccg tggccggcat tatttcctag ttcttcttgt aaccctgagg   3780

tgccagcgcg gggagtgagg aggggtcagg gggctaagga tgcaacctct gacgttctgc   3840

gccttcctag gagagtctta catgtgttga gatttcacaa gcaatgcgag ttgtaaaata   3900

ccagctctac aagaagctag gctctgtgac ggcatagttt tcagtagctt tatcacaata   3960

ttcacaatgg agaattatat gacatggtag cagaaatagg cccttttatg tgttgcttct   4020

attttacctc aaattgtaga tatagggtaa tcaataaaat ccatccatgc ctttcacaca   4080

ctaagt                                                              4086


<210>  4793
<211>  934
<212>  PRT
<213>  Homo sapiens

<400>  4793

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala 
        515                 520                 525


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr 
    530                 535                 540


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe 
545                 550                 555                 560


Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys 
                565                 570                 575


Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly 
            580                 585                 590


Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro 
        595                 600                 605


Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val 
    610                 615                 620


Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro 
625                 630                 635                 640


Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu 
                645                 650                 655


Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys 
            660                 665                 670


Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys 
        675                 680                 685


Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp 
    690                 695                 700


Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser 
705                 710                 715                 720


Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys 
                725                 730                 735


Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys 
            740                 745                 750


Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro 
        755                 760                 765


Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln 
    770                 775                 780


Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys 
785                 790                 795                 800


Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe 
                805                 810                 815


Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys 
            820                 825                 830


Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly 
        835                 840                 845


Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg 
    850                 855                 860


Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe 
865                 870                 875                 880


Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu 
                885                 890                 895


Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro 
            900                 905                 910


Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln 
        915                 920                 925


Glu Pro Asp Pro Thr Trp 
    930


<210>  4794
<211>  4250
<212>  DNA
<213>  Homo sapiens

<400>  4794
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   2040

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2100

taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2160

ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2220

ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2280

ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2340

ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2400

atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2460

agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2520

agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2580

tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2640

ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2700

tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2760

ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2820

atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2880

ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2940

tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   3000

ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   3060

tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3120

ttatcaaatt cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg   3180

atcagagtga gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag   3240

ttccagccac agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag   3300

accccacgtg gtagacctct tccctcctag gcttaaagta tcagtggttg agaagagctt   3360

ttcggacctg ttactacccc aagctgtagc cttgagttac ggtgtttatt ttccaatcaa   3420

gtgaagatat ctcctacttc tcctactgga acatctcagc ttctgcagtg aagaaaaatt   3480

cctgtgatag ttcagttctt tagtttttct atttgaaaaa aaaaaatcat ttaaatgatc   3540

ctttgttcac ggctctcctt aatgactgag tgaacagttc ctatctgtat atttgactaa   3600

accttttcct aagctatctc tcatggttcc tatgtttttt tatcataatt aaaagcaaaa   3660

ccatctggat cacctaacag tcagaggtca gtatctcagc gtgtgaatta tagaggaaat   3720

acagagagaa cctcttccac ttttactttt cgtccaaata aaatgcatgg tgtaccagaa   3780

gttgaagatc gggttgagga ttggggctag ctcgatgaca ctaaggcccc aacatcgcgg   3840

gacctgctgt ggcgcggatt cttaggaacg ctgttctagc cggccccctc tccaggggtc   3900

gccgtggccg gcattatttc ctagttcttc ttgtaaccct gaggtgccag cgcggggagt   3960

gaggaggggt cagggggcta aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt   4020

cttacatgtg ttgagatttc acaagcaatg cgagttgtaa aataccagct ctacaagaag   4080

ctaggctctg tgacggcata gttttcagta gctttatcac aatattcaca atggagaatt   4140

atatgacatg gtagcagaaa taggcccttt tatgtgttgc ttctatttta cctcaaattg   4200

tagatatagg gtaatcaata aaatccatcc atgcctttca cacactaagt              4250


<210>  4795
<211>  909
<212>  PRT
<213>  Homo sapiens

<400>  4795

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
465                 470                 475                 480


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
                485                 490                 495


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
            500                 505                 510


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
        515                 520                 525


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
    530                 535                 540


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
545                 550                 555                 560


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
                565                 570                 575


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
            580                 585                 590


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
        595                 600                 605


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
    610                 615                 620


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
625                 630                 635                 640


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
                645                 650                 655


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
            660                 665                 670


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
        675                 680                 685


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
    690                 695                 700


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
705                 710                 715                 720


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
                725                 730                 735


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
            740                 745                 750


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
        755                 760                 765


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
    770                 775                 780


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
785                 790                 795                 800


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
                805                 810                 815


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
            820                 825                 830


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
        835                 840                 845


Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu 
    850                 855                 860


Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu 
865                 870                 875                 880


Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp 
                885                 890                 895


Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
            900                 905


<210>  4796
<211>  4914
<212>  DNA
<213>  Homo sapiens

<400>  4796
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1860

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1920

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1980

aatcaaaccc ggagttcttg aaaggatcgt ccgcgggagt aataaaatca agttcgttgt   2040

taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta aaataaacac   2100

taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa aggttcctga   2160

aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag ctgttcgaac   2220

cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag agttttcctt   2280

tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc tcttcaatga   2340

gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg cgttatttga   2400

gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat tccgaagacc   2460

atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca aaattaagtt   2520

catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct cctctaagag   2580

ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag gtgttgaaga   2640

ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct cgaaagttga   2700

aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat ttggtgaagc   2760

tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta accctggctg   2820

tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct acctggaaat   2880

cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg tcattagacc   2940

atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag aaggccccgt   3000

gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag gtaaaaggac   3060

ctcttccctc ctagggtaaa tcagcttctg tgtcagggat gctgtgtggt gtccatctga   3120

accccctgca tacgcgtagc taatgtgatc tccccacttt cacataagat ggtggccctg   3180

ccttcaggga atgtgggagc caggtgggag ccttcccgga tatttaagct agaagattct   3240

acagggagat tctccttgga tcaatatatg tctctcagtc aaagatgtaa aagcactttt   3300

gccttaaaaa gaatgttctg tttctaaata gagtcaacgt tgtcctcctc attggaattc   3360

actatgagtc agaatcatta gactgacttt tttttttcca tagtaatagt attttgcaga   3420

gtctcacaga gctgcagatc ttttgttcat cttgcagagt taacaagtct gatcctgtta   3480

gtccagattt cttaaatttg gccaagttat aataggagca gtagcttgag acccgaagtc   3540

aggaaacttt gacaatggat tttttttttt aatccagaga cttgtactgg aatttgcctt   3600

accctgtcag ctcatggact taaggtttca tcccgcttta tgagtgcttc tgaatccaag   3660

tcattgttac ctgaatttgc aaattaagtt gtgatattcg tgactgttaa attcctgtaa   3720

ttagattaac ctctttgctt gcttgtttgt tttctctcct attttagctt aaagtatcag   3780

tggttgagaa gagcttttcg gacctgttac taccccaagc tgtgtaatat acttgtataa   3840

cagaaatacc ttctatacaa accttttttt ctacttttag atagaaatgt ctactttttc   3900

agcagttctg tgaattaaag agcagagtga ctgtgggtct ggaatggctg gtgtacttgg   3960

gaatgtacta tcaggatttt acagcaatgc tgggaaatga cagggaaaat gacaggaatg   4020

aatctcacca gattttttat gtactcagca gagccttgag ttacggtgtt tattttccaa   4080

tcaagtgaag atatctccta cttctcctac tggaacatct cagcttctgc agtgaagaaa   4140

aattcctgtg atagttcagt tctttagttt ttctatttga aaaaaaaaaa tcatttaaat   4200

gatcctttgt tcacggctct ccttaatgac tgagtgaaca gttcctatct gtatatttga   4260

ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt tttttatcat aattaaaagc   4320

aaaaccatct ggatcaccta acagtcagag gtcagtatct cagcgtgtga attatagagg   4380

aaatacagag agaacctctt ccacttttac ttttcgtcca aataaaatgc atggtgtacc   4440

agaagttgaa gatcgggttg aggattgggg ctagctcgat gacactaagg ccccaacatc   4500

gcgggacctg ctgtggcgcg gattcttagg aacgctgttc tagccggccc cctctccagg   4560

ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa ccctgaggtg ccagcgcggg   4620

gagtgaggag gggtcagggg gctaaggatg caacctctga cgttctgcgc cttcctagga   4680

gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc agctctacaa   4740

gaagctaggc tctgtgacgg catagttttc agtagcttta tcacaatatt cacaatggag   4800

aattatatga catggtagca gaaataggcc cttttatgtg ttgcttctat tttacctcaa   4860

attgtagata tagggtaatc aataaaatcc atccatgcct ttcacacact aagt         4914


<210>  4797
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  4797

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg 
            420                 425                 430


Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe 
        435                 440                 445


Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val 
    450                 455                 460


Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile 
465                 470                 475                 480


Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
                485                 490


<210>  4798
<211>  8007
<212>  DNA
<213>  Homo sapiens

<400>  4798
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   1980

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gcttagattt   2040

gttgacagcg gtttcctgga gtgctgtctt gagaacgatt ctgaggaggc tcagcaagaa   2100

agagtgtttc agttgattgg gtgtgtctgt catggagaag gaactcaagc tcttggactc   2160

accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgtatgtg   2220

gaaggcttgc cagaggggat tcccttccga agccctacct ggtttggaat tccacgactt   2280

gaaaggatcg tccgcgggag taataaaatc aagttcgttg ttaaaaaacc tgaactagtt   2340

atttcctact tgcctcctgg gatggctagt aaaataaaca ctaaagcttt gcagtccccc   2400

aaaagaccac gaagtcctgg gagtaattca aaggttcctg aaattgaggt caccgtggaa   2460

ggccctaata acaacaatcc tcaaacctca gctgttcgaa ccccgaccca gactaacggt   2520

tctaacgttc ccttcaagcc acgagggaga gagttttcct ttgaggcctg gaatgccaaa   2580

atcacggacc taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg ggaagctctt   2640

ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg agtctttccc ggaagacttt   2700

tatgtggaag gcttacctga gggtgtgcca ttccgaagac catcgacttt tggcattccg   2760

aggctggaga agatactcag aaacaaagcc aaaattaagt tcatcattaa aaagcccgaa   2820

atgtttgaga cggcgattaa ggagagcacc tcctctaaga gccctcccag aaaaataaat   2880

tcatcaccca atgttaatac tactgcatca ggtgttgaag accttaacat cattcaggtg   2940

acaattccag atgatgataa tgaaagactc tcgaaagttg aaaaagctag acagctaaga   3000

gaacaagtga atgacctctt tagtcggaaa tttggtgaag ctattggtat gggttttcct   3060

gtgaaagttc cctacaggaa aatcacaatt aaccctggct gtgtggtggt tgatggcatg   3120

cccccggggg tgtccttcaa agcccccagc tacctggaaa tcagctccat gagaaggatc   3180

ttagactctg ccgagtttat caaattcacg gtcattaggt aagtgagagt ttcctgctta   3240

gtcacaggag cgaatctgga gctcatgagg ctgactcttc taaaatgcag ccacaggtag   3300

tcatcgaatc cggcttccta tgctgtgcaa tcaacaaatc aaaataactt gtgtcatcat   3360

tagaatgtca gatgtgcttc tacgaactaa gctgactctt ttaattcttt ggcaaagggt   3420

tggcaaacta ggactgtttg ccaaattcag gctgcctcct atttttagag tcttcctgaa   3480

acacagctac acccgtatta tccatggctg ctttcctgtc acagtgagta agtagctggg   3540

actgagaagg catggcctcc aaagtctaaa atatttactc tctagcactt tgtagaaaaa   3600

ccttagctag gcacagtggc taacgcctgt aatcccagca ttttgggagg ccaaggcagg   3660

cagatcacct gaggtcagga gttccagacc agcctggcca acatggtgaa atcccatctc   3720

tacaaaaata aaacagttag ctgggcatga tggcgggtgc ctgtaatccc agctactcgg   3780

gaggctgagg caggatagtc gcttgaaccc aggaggtgga ggttgcaatg agccaagatc   3840

atgccactgc actccagcct ggacgacaga gtgagactcc atcacaagaa aaaaagaact   3900

ttgtcaacct ctgtcttagg gcgccttgtc acaggcttcg ggtcagacgg attcaacctt   3960

gcatcagcca tttgttagcc aggtcactct gttctttgtc tgtaaatgag attgatcgtt   4020

gttcccactg agagtgtcag ctccttcccg tagagcaggc atgatgattg tactcacctc   4080

tgacaccatt gtgagtgcca cattccttcc cacgtccttg tcactgtaag agatgcccac   4140

ctgagcacca accccaggtt atcttcccct ttgtcttcca gccccccaga aacagctacg   4200

actcaaccta cccaatcatt tcatcatcag attgccactg tctctagttc aggtctcttg   4260

ggactggcac tcagaaatct cataataaat cctcttgagg cttctcatac actcgtcttc   4320

ttccaatctt ctttccctca aaatctcata ttttggttcc acttcaccca ccgtcattct   4380

ccatatcact cccaggagtt aggcaaaaag ccccttccgt tcttccgtat gttaaactta   4440

gaatcactct gttccctgct ctgcgtttct attttttgtt tttcctccat ttactagtag   4500

cttaacactt tctaacagtg ttcttattat tgatacgtat ctatctcttc cataagctta   4560

taaggtcacg gataatactt ctcattgtag tacgtaaatg acgtgggcta gatatgagtt   4620

gaataaacag ttatacctgt aaattcttac agagtgaaaa taaattgtta tactttacaa   4680

tttgtttctc tctttagacc atttccagga cttgtgatta ataaccgtga gtattttgtg   4740

aagtgttttg tttttgtttt ttcctggggt ctgacgtgtg tgcgtgtgag tgtgtataca   4800

tgcttaacgt atatcacgtt acttcaccta tgtcagtaac caggccaaat acttgtttta   4860

gccctcagta aaaacaccag gcacttccta gttgtaaaat tattcaagct tcttaacttc   4920

ctatcctcga tgcacttaat cataaaatgg taataatagc accgattttg ggggagtcgt   4980

tccagtagat ggaaagcatc tggaacaggt gtcagcaagc tcctgccgac gtgtatgcat   5040

aaagttttat tgaaaccacc atcgtgtcca tttgtttatg gcagaactga gagatggcag   5100

cagcaagtgt gtgcctgcaa aacctaaaat atttactaat tggctctgca agaaaagagt   5160

ttgcatcccc ctaacctaga acagtgtcta gcctctagta tgtgtttagc ctacagtatg   5220

tgctcagcga atacaatcta tatttattac tgcttttatg actgttataa ttactgtgct   5280

tggatttcgt tacaaagtaa gtcacaatgt gcctgcttct gttagtattt cagcacagtg   5340

cctggcacac atggggctct caaatattgc tgagcgagtg aacaaatgtc ctttcaattc   5400

cttaacgttg atgtcatttt caatagtatt ttgagccaaa cttaattttg cgagtgtgtt   5460

ttgttttctt aactttatta ttaaaaatgt ataaaagtga ggccaggcgt ggtggctcac   5520

gcctgtaatc ccagcagttt gggaggctga ggcaggcgga tcagttgagg ttgggagttg   5580

gagaccagcc cgtccaacat ggtgaaagcc tgtctctact aaaaatacaa aaatcagctg   5640

ggtgtggtgg cgcgtgcctg taatcccagc tactcaggag gctgaggcag gagagttgct   5700

tgaatcctag aggtggaggt tgcagtgagc tgagatcgtg ccattgcact ccagcctggg   5760

caacaagagc aaaactctgt cccaataaat aaataaataa aatgttctct tttgttcctg   5820

ttcttgtgcg gtagtgtggt atagagtttt atggtaatta ctgtgaatta gtgattctga   5880

gggacatatc agaactctga ggtttgtttc cttctcatct tgagggaaac agcaaatgta   5940

tgttaaaatg cttttccaag ggaacaacac atccttacat tatttaaacc aatctgcttc   6000

attttcagag ctggttgatc agagtgagtc agaaggcccc gtgatacaag aatcagctga   6060

accaagccag ttggaagttc cagccacaga agaaataaaa gagactgatg gaagctctca   6120

gatcaagcaa gaaccagacc ccacgtggta gacctcttcc ctcctagggt aaatcagctt   6180

ctgtgtcagg gatgctgtgt ggtgtccatc tgaaccccct gcatacgcgt agctaatgtg   6240

atctccccac tttcacataa gatggtggcc ctgccttcag ggaatgtggg agccaggtgg   6300

gagccttccc ggatatttaa gctagaagat tctacaggga gattctcctt ggatcaatat   6360

atgtctctca gtcaaagatg taaaagcact tttgccttaa aaagaatgtt ctgtttctaa   6420

atagagtcaa cgttgtcctc ctcattggaa ttcactatga gtcagaatca ttagactgac   6480

tttttttttt ccatagtaat agtattttgc agagtctcac agagctgcag atcttttgtt   6540

catcttgcag agttaacaag tctgatcctg ttagtccaga tttcttaaat ttggccaagt   6600

tataatagga gcagtagctt gagacccgaa gtcaggaaac tttgacaatg gatttttttt   6660

tttaatccag agacttgtac tggaatttgc cttaccctgt cagctcatgg acttaaggtt   6720

tcatcccgct ttatgagtgc ttctgaatcc aagtcattgt tacctgaatt tgcaaattaa   6780

gttgtgatat tcgtgactgt taaattcctg taattagatt aacctctttg cttgcttgtt   6840

tgttttctct cctattttag cttaaagtat cagtggttga gaagagcttt tcggacctgt   6900

tactacccca agctgtgtaa tatacttgta taacagaaat accttctata caaacctttt   6960

tttctacttt tagatagaaa tgtctacttt ttcagcagtt ctgtgaatta aagagcagag   7020

tgactgtggg tctggaatgg ctggtgtact tgggaatgta ctatcaggat tttacagcaa   7080

tgctgggaaa tgacagggaa aatgacagga atgaatctca ccagattttt tatgtactca   7140

gcagagcctt gagttacggt gtttattttc caatcaagtg aagatatctc ctacttctcc   7200

tactggaaca tctcagcttc tgcagtgaag aaaaattcct gtgatagttc agttctttag   7260

tttttctatt tgaaaaaaaa aaatcattta aatgatcctt tgttcacggc tctccttaat   7320

gactgagtga acagttccta tctgtatatt tgactaaacc ttttcctaag ctatctctca   7380

tggttcctat gtttttttat cataattaaa agcaaaacca tctggatcac ctaacagtca   7440

gaggtcagta tctcagcgtg tgaattatag aggaaataca gagagaacct cttccacttt   7500

tacttttcgt ccaaataaaa tgcatggtgt accagaagtt gaagatcggg ttgaggattg   7560

gggctagctc gatgacacta aggccccaac atcgcgggac ctgctgtggc gcggattctt   7620

aggaacgctg ttctagccgg ccccctctcc aggggtcgcc gtggccggca ttatttccta   7680

gttcttcttg taaccctgag gtgccagcgc ggggagtgag gaggggtcag ggggctaagg   7740

atgcaacctc tgacgttctg cgccttccta ggagagtctt acatgtgttg agatttcaca   7800

agcaatgcga gttgtaaaat accagctcta caagaagcta ggctctgtga cggcatagtt   7860

ttcagtagct ttatcacaat attcacaatg gagaattata tgacatggta gcagaaatag   7920

gcccttttat gtgttgcttc tattttacct caaattgtag atatagggta atcaataaaa   7980

tccatccatg cctttcacac actaagt                                       8007


<210>  4799
<211>  544
<212>  PRT
<213>  Homo sapiens

<400>  4799

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile 
        515                 520                 525


Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  4800
<211>  5069
<212>  DNA
<213>  Homo sapiens

<400>  4800
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gtcaaagaag attggaatgt   1980

cagaattacc aagctacgga agcaagtgga agagattttt aatttgaaat ttgctcaagc   2040

tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt   2100

cttgaaagga tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa acctgaacta   2160

gttatttcct acttgcctcc tgggatggct agtaaaataa acactaaagc tttgcagtcc   2220

cccaaaagac cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg   2280

gaaggcccta ataacaacaa tcctcaaacc tcagctgttc gaaccccgac ccagactaac   2340

ggttctaacg ttcccttcaa gccacgaggg agagagtttt cctttgaggc ctggaatgcc   2400

aaaatcacgg acctaaaaca gaaagttgaa aatctcttca atgagaaatg tggggaagct   2460

cttggcctta aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac   2520

ttttatgtgg aaggcttacc tgagggtgtg ccattccgaa gaccatcgac ttttggcatt   2580

ccgaggctgg agaagatact cagaaacaaa gccaaaatta agttcatcat taaaaagccc   2640

gaaatgtttg agacggcgat taaggagagc acctcctcta agagccctcc cagaaaaata   2700

aattcatcac ccaatgttaa tactactgca tcaggtgttg aagaccttaa catcattcag   2760

gtgacaattc cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta   2820

agagaacaag tgaatgacct ctttagtcgg aaatttggtg aagctattgg tatgggtttt   2880

cctgtgaaag ttccctacag gaaaatcaca attaaccctg gctgtgtggt ggttgatggc   2940

atgcccccgg gggtgtcctt caaagccccc agctacctgg aaatcagctc catgagaagg   3000

atcttagact ctgccgagtt tatcaaattc acggtcatta gaccatttcc aggacttgtg   3060

attaataacc agctggttga tcagagtgag tcagaaggcc ccgtgataca agaatcagct   3120

gaaccaagcc agttggaagt tccagccaca gaagaaataa aagagactga tggaagctct   3180

cagatcaagc aagaaccaga ccccacgtgg tagacctctt ccctcctagg gtaaatcagc   3240

ttctgtgtca gggatgctgt gtggtgtcca tctgaacccc ctgcatacgc gtagctaatg   3300

tgatctcccc actttcacat aagatggtgg ccctgccttc agggaatgtg ggagccaggt   3360

gggagccttc ccggatattt aagctagaag attctacagg gagattctcc ttggatcaat   3420

atatgtctct cagtcaaaga tgtaaaagca cttttgcctt aaaaagaatg ttctgtttct   3480

aaatagagtc aacgttgtcc tcctcattgg aattcactat gagtcagaat cattagactg   3540

actttttttt ttccatagta atagtatttt gcagagtctc acagagctgc agatcttttg   3600

ttcatcttgc agagttaaca agtctgatcc tgttagtcca gatttcttaa atttggccaa   3660

gttataatag gagcagtagc ttgagacccg aagtcaggaa actttgacaa tggatttttt   3720

tttttaatcc agagacttgt actggaattt gccttaccct gtcagctcat ggacttaagg   3780

tttcatcccg ctttatgagt gcttctgaat ccaagtcatt gttacctgaa tttgcaaatt   3840

aagttgtgat attcgtgact gttaaattcc tgtaattaga ttaacctctt tgcttgcttg   3900

tttgttttct ctcctatttt agcttaaagt atcagtggtt gagaagagct tttcggacct   3960

gttactaccc caagctgtgt aatatacttg tataacagaa ataccttcta tacaaacctt   4020

tttttctact tttagataga aatgtctact ttttcagcag ttctgtgaat taaagagcag   4080

agtgactgtg ggtctggaat ggctggtgta cttgggaatg tactatcagg attttacagc   4140

aatgctggga aatgacaggg aaaatgacag gaatgaatct caccagattt tttatgtact   4200

cagcagagcc ttgagttacg gtgtttattt tccaatcaag tgaagatatc tcctacttct   4260

cctactggaa catctcagct tctgcagtga agaaaaattc ctgtgatagt tcagttcttt   4320

agtttttcta tttgaaaaaa aaaaatcatt taaatgatcc tttgttcacg gctctcctta   4380

atgactgagt gaacagttcc tatctgtata tttgactaaa ccttttccta agctatctct   4440

catggttcct atgttttttt atcataatta aaagcaaaac catctggatc acctaacagt   4500

cagaggtcag tatctcagcg tgtgaattat agaggaaata cagagagaac ctcttccact   4560

tttacttttc gtccaaataa aatgcatggt gtaccagaag ttgaagatcg ggttgaggat   4620

tggggctagc tcgatgacac taaggcccca acatcgcggg acctgctgtg gcgcggattc   4680

ttaggaacgc tgttctagcc ggccccctct ccaggggtcg ccgtggccgg cattatttcc   4740

tagttcttct tgtaaccctg aggtgccagc gcggggagtg aggaggggtc agggggctaa   4800

ggatgcaacc tctgacgttc tgcgccttcc taggagagtc ttacatgtgt tgagatttca   4860

caagcaatgc gagttgtaaa ataccagctc tacaagaagc taggctctgt gacggcatag   4920

ttttcagtag ctttatcaca atattcacaa tggagaatta tatgacatgg tagcagaaat   4980

aggccctttt atgtgttgct tctattttac ctcaaattgt agatataggg taatcaataa   5040

aatccatcca tgcctttcac acactaagt                                     5069


<210>  4801
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  4801

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys 
                565                 570                 575


Asn Leu Asn 



<210>  4802
<211>  4287
<212>  DNA
<213>  Homo sapiens

<400>  4802
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   1980

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2040

gaaatttgct tagatttgtt gacagcggtt tcctggagtg ctgtcttgag aacgattctg   2100

aggaggctca gcaagaaaga gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa   2160

ctcaagctct tggactcacc gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc   2220

cggagttctt gtatgtggaa ggcttgccag aggggattcc cttccgaagc cctacctggt   2280

ttggaattcc acgacttgaa aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta   2340

aaaaacctga actagttatt tcctacttgc ctcctgggat ggctagtaaa ataaacacta   2400

aagctttgca gtcccccaaa agaccacgaa gtcctgggag taattcaaag gttcctgaaa   2460

ttgaggtcac cgtggaaggc cctaataaca acaatcctca aacctcagct gttcgaaccc   2520

cgacccagac taacggttct aacgttccct tcaagccacg agggagagag ttttcctttg   2580

aggcctggaa tgccaaaatc acggacctaa aacagaaagt tgaaaatctc ttcaatgaga   2640

aatgtgggga agctcttggc cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt   2700

ctttcccgga agacttttat gtggaaggct tacctgaggg tgtgccattc cgaagaccat   2760

cgacttttgg cattccgagg ctggagaaga tactcagaaa caaagccaaa attaagttca   2820

tcattaaaaa gcccgaaatg tttgagacgg cgattaagga gagcacctcc tctaagagcc   2880

ctcccagaaa aataaattca tcacccaatg ttaatactac tgcatcaggt gttgaagacc   2940

ttaacatcat tcaggtgaca attccagatg atgataatga aagactctcg aaagttgaaa   3000

aagctagaca gctaagagaa caagtgaatg acctctttag tcggaaattt ggtgaagcta   3060

ttggtatggg ttttcctgtg aaagttccct acaggaaaat cacaattaac cctggctgtg   3120

tggtggttga tggcatgccc ccgggggtgt ccttcaaagc ccccagctac ctggaaatca   3180

gctccatgag aaggatctta gactctgccg agtttatcaa attcacggtc attagaccat   3240

ttccaggact tgtgattaat aaccagctgg ttgatcagag tgagtcagaa ggccccgtga   3300

tacaagaatc agctgaacca agccagttgg aagttccagc cacagaagaa ataaaagaga   3360

ctgatggaag ctctcagatc aagcaagaac cagaccccac gtggtagacc tcttccctcc   3420

taggagcctt gagttacggt gtttattttc caatcaagtg aagatatctc ctacttctcc   3480

tactggaaca tctcagcttc tgcagtgaag aaaaattcct gtgatagttc agttctttag   3540

tttttctatt tgaaaaaaaa aaatcattta aatgatcctt tgttcacggc tctccttaat   3600

gactgagtga acagttccta tctgtatatt tgactaaacc ttttcctaag ctatctctca   3660

tggttcctat gtttttttat cataattaaa agcaaaacca tctggatcac ctaacagtca   3720

gaggtcagta tctcagcgtg tgaattatag aggaaataca gagagaacct cttccacttt   3780

tacttttcgt ccaaataaaa tgcatggtgt accagaagtt gaagatcggg ttgaggattg   3840

gggctagctc gatgacacta aggccccaac atcgcgggac ctgctgtggc gcggattctt   3900

aggaacgctg ttctagccgg ccccctctcc aggggtcgcc gtggccggca ttatttccta   3960

gttcttcttg taaccctgag gtgccagcgc ggggagtgag gaggggtcag ggggctaagg   4020

atgcaacctc tgacgttctg cgccttccta ggagagtctt acatgtgttg agatttcaca   4080

agcaatgcga gttgtaaaat accagctcta caagaagcta ggctctgtga cggcatagtt   4140

ttcagtagct ttatcacaat attcacaatg gagaattata tgacatggta gcagaaatag   4200

gcccttttat gtgttgcttc tattttacct caaattgtag atatagggta atcaataaaa   4260

tccatccatg cctttcacac actaagt                                       4287


<210>  4803
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  4803

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  4804
<211>  4064
<212>  DNA
<213>  Homo sapiens

<400>  4804
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gctcaagctc ttggactcac cgaggcagta aaagtaccat   1920

atcctgtgtt tgaatcaaac ccggagttct tgtatgtgga aggcttgcca gaggggattc   1980

ccttccgaag ccctacctgg tttggaattc cacgacttga aaggatcgtc cgcgggagta   2040

ataaaatcaa gttcgttgtt aaaaaacctg aactagttat ttcctacttg cctcctggga   2100

tggctagtaa aataaacact aaagctttgc agtcccccaa aagaccacga agtcctggga   2160

gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg ccctaataac aacaatcctc   2220

aaacctcagc tgttcgaacc ccgacccaga ctaacggttc taacgttccc ttcaagccac   2280

gagggagaga gttttccttt gaggcctgga atgccaaaat cacggaccta aaacagaaag   2340

ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg   2400

tgccgttcgc gttatttgag tctttcccgg aagactttta tgtggaaggc ttacctgagg   2460

gtgtgccatt ccgaagacca tcgacttttg gcattccgag gctggagaag atactcagaa   2520

acaaagccaa aattaagttc atcattaaaa agcccgaaat gtttgagacg gcgattaagg   2580

agagcacctc ctctaagagc cctcccagaa aaataaattc atcacccaat gttaatacta   2640

ctgcatcagg tgttgaagac cttaacatca ttcaggtgac aattccagat gatgataatg   2700

aaagactctc gaaagttgaa aaagctagac agctaagaga acaagtgaat gacctcttta   2760

gtcggaaatt tggtgaagct attggtatgg gttttcctgt gaaagttccc tacaggaaaa   2820

tcacaattaa ccctggctgt gtggtggttg atggcatgcc cccgggggtg tccttcaaag   2880

cccccagcta cctggaaatc agctccatga gaaggatctt agactctgcc gagtttatca   2940

aattcacggt cattagacca tttccaggac ttgtgattaa taaccagctg gttgatcaga   3000

gtgagtcaga aggccccgtg atacaagaat cagctgaacc aagccagttg gaagttccag   3060

ccacagaaga aataaaagag actgatggaa gctctcagat caagcaagaa ccagacccca   3120

cgtggtagac ctcttccctc ctaggcttaa agtatcagtg gttgagaaga gcttttcgga   3180

cctgttacta ccccaagctg tagccttgag ttacggtgtt tattttccaa tcaagtgaag   3240

atatctccta cttctcctac tggaacatct cagcttctgc agtgaagaaa aattcctgtg   3300

atagttcagt tctttagttt ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt   3360

tcacggctct ccttaatgac tgagtgaaca gttcctatct gtatatttga ctaaaccttt   3420

tcctaagcta tctctcatgg ttcctatgtt tttttatcat aattaaaagc aaaaccatct   3480

ggatcaccta acagtcagag gtcagtatct cagcgtgtga attatagagg aaatacagag   3540

agaacctctt ccacttttac ttttcgtcca aataaaatgc atggtgtacc agaagttgaa   3600

gatcgggttg aggattgggg ctagctcgat gacactaagg ccccaacatc gcgggacctg   3660

ctgtggcgcg gattcttagg aacgctgttc tagccggccc cctctccagg ggtcgccgtg   3720

gccggcatta tttcctagtt cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag   3780

gggtcagggg gctaaggatg caacctctga cgttctgcgc cttcctagga gagtcttaca   3840

tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc agctctacaa gaagctaggc   3900

tctgtgacgg catagttttc agtagcttta tcacaatatt cacaatggag aattatatga   3960

catggtagca gaaataggcc cttttatgtg ttgcttctat tttacctcaa attgtagata   4020

tagggtaatc aataaaatcc atccatgcct ttcacacact aagt                    4064


<210>  4805
<211>  908
<212>  PRT
<213>  Homo sapiens

<400>  4805

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala 
                485                 490                 495


Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser 
            500                 505                 510


Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        515                 520                 525


Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg 
    530                 535                 540


Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile 
545                 550                 555                 560


Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu 
                565                 570                 575


Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro 
            580                 585                 590


Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr 
        595                 600                 605


Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe 
    610                 615                 620


Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile 
625                 630                 635                 640


Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly 
                645                 650                 655


Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe 
            660                 665                 670


Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val 
        675                 680                 685


Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile 
    690                 695                 700


Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met 
705                 710                 715                 720


Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg 
                725                 730                 735


Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu 
            740                 745                 750


Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg 
        755                 760                 765


Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp 
    770                 775                 780


Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val 
785                 790                 795                 800


Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val 
                805                 810                 815


Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu 
            820                 825                 830


Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe 
        835                 840                 845


Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val 
    850                 855                 860


Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro 
865                 870                 875                 880


Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly 
                885                 890                 895


Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
            900                 905


<210>  4806
<211>  7133
<212>  DNA
<213>  Homo sapiens

<400>  4806
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gctcaagctc ttggactcac   1980

cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct tgtatgtgga   2040

aggcttgcca gaggggattc ccttccgaag ccctacctgg tttggaattc cacgacttga   2100

aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg aactagttat   2160

ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc agtcccccaa   2220

aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg   2280

ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga ctaacggttc   2340

taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga atgccaaaat   2400

cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg   2460

ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg aagactttta   2520

tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg gcattccgag   2580

gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa agcccgaaat   2640

gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa aaataaattc   2700

atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca ttcaggtgac   2760

aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac agctaagaga   2820

acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg gttttcctgt   2880

gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg atggcatgcc   2940

cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga gaaggatctt   3000

agactctgcc gagtttatca aattcacggt cattaggtaa gtgagagttt cctgcttagt   3060

cacaggagcg aatctggagc tcatgaggct gactcttcta aaatgcagcc acaggtagtc   3120

atcgaatccg gcttcctatg ctgtgcaatc aacaaatcaa aataacttgt gtcatcatta   3180

gaatgtcaga tgtgcttcta cgaactaagc tgactctttt aattctttgg caaagggttg   3240

gcaaactagg actgtttgcc aaattcaggc tgcctcctat ttttagagtc ttcctgaaac   3300

acagctacac ccgtattatc catggctgct ttcctgtcac agtgagtaag tagctgggac   3360

tgagaaggca tggcctccaa agtctaaaat atttactctc tagcactttg tagaaaaacc   3420

ttagctaggc acagtggcta acgcctgtaa tcccagcatt ttgggaggcc aaggcaggca   3480

gatcacctga ggtcaggagt tccagaccag cctggccaac atggtgaaat cccatctcta   3540

caaaaataaa acagttagct gggcatgatg gcgggtgcct gtaatcccag ctactcggga   3600

ggctgaggca ggatagtcgc ttgaacccag gaggtggagg ttgcaatgag ccaagatcat   3660

gccactgcac tccagcctgg acgacagagt gagactccat cacaagaaaa aaagaacttt   3720

gtcaacctct gtcttagggc gccttgtcac aggcttcggg tcagacggat tcaaccttgc   3780

atcagccatt tgttagccag gtcactctgt tctttgtctg taaatgagat tgatcgttgt   3840

tcccactgag agtgtcagct ccttcccgta gagcaggcat gatgattgta ctcacctctg   3900

acaccattgt gagtgccaca ttccttccca cgtccttgtc actgtaagag atgcccacct   3960

gagcaccaac cccaggttat cttccccttt gtcttccagc cccccagaaa cagctacgac   4020

tcaacctacc caatcatttc atcatcagat tgccactgtc tctagttcag gtctcttggg   4080

actggcactc agaaatctca taataaatcc tcttgaggct tctcatacac tcgtcttctt   4140

ccaatcttct ttccctcaaa atctcatatt ttggttccac ttcacccacc gtcattctcc   4200

atatcactcc caggagttag gcaaaaagcc ccttccgttc ttccgtatgt taaacttaga   4260

atcactctgt tccctgctct gcgtttctat tttttgtttt tcctccattt actagtagct   4320

taacactttc taacagtgtt cttattattg atacgtatct atctcttcca taagcttata   4380

aggtcacgga taatacttct cattgtagta cgtaaatgac gtgggctaga tatgagttga   4440

ataaacagtt atacctgtaa attcttacag agtgaaaata aattgttata ctttacaatt   4500

tgtttctctc tttagaccat ttccaggact tgtgattaat aaccgtgagt attttgtgaa   4560

gtgttttgtt tttgtttttt cctggggtct gacgtgtgtg cgtgtgagtg tgtatacatg   4620

cttaacgtat atcacgttac ttcacctatg tcagtaacca ggccaaatac ttgttttagc   4680

cctcagtaaa aacaccaggc acttcctagt tgtaaaatta ttcaagcttc ttaacttcct   4740

atcctcgatg cacttaatca taaaatggta ataatagcac cgattttggg ggagtcgttc   4800

cagtagatgg aaagcatctg gaacaggtgt cagcaagctc ctgccgacgt gtatgcataa   4860

agttttattg aaaccaccat cgtgtccatt tgtttatggc agaactgaga gatggcagca   4920

gcaagtgtgt gcctgcaaaa cctaaaatat ttactaattg gctctgcaag aaaagagttt   4980

gcatccccct aacctagaac agtgtctagc ctctagtatg tgtttagcct acagtatgtg   5040

ctcagcgaat acaatctata tttattactg cttttatgac tgttataatt actgtgcttg   5100

gatttcgtta caaagtaagt cacaatgtgc ctgcttctgt tagtatttca gcacagtgcc   5160

tggcacacat ggggctctca aatattgctg agcgagtgaa caaatgtcct ttcaattcct   5220

taacgttgat gtcattttca atagtatttt gagccaaact taattttgcg agtgtgtttt   5280

gttttcttaa ctttattatt aaaaatgtat aaaagtgagg ccaggcgtgg tggctcacgc   5340

ctgtaatccc agcagtttgg gaggctgagg caggcggatc agttgaggtt gggagttgga   5400

gaccagcccg tccaacatgg tgaaagcctg tctctactaa aaatacaaaa atcagctggg   5460

tgtggtggcg cgtgcctgta atcccagcta ctcaggaggc tgaggcagga gagttgcttg   5520

aatcctagag gtggaggttg cagtgagctg agatcgtgcc attgcactcc agcctgggca   5580

acaagagcaa aactctgtcc caataaataa ataaataaaa tgttctcttt tgttcctgtt   5640

cttgtgcggt agtgtggtat agagttttat ggtaattact gtgaattagt gattctgagg   5700

gacatatcag aactctgagg tttgtttcct tctcatcttg agggaaacag caaatgtatg   5760

ttaaaatgct tttccaaggg aacaacacat ccttacatta tttaaaccaa tctgcttcat   5820

tttcagagct ggttgatcag agtgagtcag aaggccccgt gatacaagaa tcagctgaac   5880

caagccagtt ggaagttcca gccacagaag aaataaaaga gactgatgga agctctcaga   5940

tcaagcaaga accagacccc acgtggtaga cctcttccct cctaggctta aagtatcagt   6000

ggttgagaag agcttttcgg acctgttact accccaagct gtgtaatata cttgtataac   6060

agaaatacct tctatacaaa cctttttttc tacttttaga tagaaatgtc tactttttca   6120

gcagttctgt gaattaaaga gcagagtgac tgtgggtctg gaatggctgg tgtacttggg   6180

aatgtactat caggatttta cagcaatgct gggaaatgac agggaaaatg acaggaatga   6240

atctcaccag attttttatg tactcagcag agccttgagt tacggtgttt attttccaat   6300

caagtgaaga tatctcctac ttctcctact ggaacatctc agcttctgca gtgaagaaaa   6360

attcctgtga tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat catttaaatg   6420

atcctttgtt cacggctctc cttaatgact gagtgaacag ttcctatctg tatatttgac   6480

taaacctttt cctaagctat ctctcatggt tcctatgttt ttttatcata attaaaagca   6540

aaaccatctg gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa ttatagagga   6600

aatacagaga gaacctcttc cacttttact tttcgtccaa ataaaatgca tggtgtacca   6660

gaagttgaag atcgggttga ggattggggc tagctcgatg acactaaggc cccaacatcg   6720

cgggacctgc tgtggcgcgg attcttagga acgctgttct agccggcccc ctctccaggg   6780

gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg   6840

agtgaggagg ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc ttcctaggag   6900

agtcttacat gtgttgagat ttcacaagca atgcgagttg taaaatacca gctctacaag   6960

aagctaggct ctgtgacggc atagttttca gtagctttat cacaatattc acaatggaga   7020

attatatgac atggtagcag aaataggccc ttttatgtgt tgcttctatt ttacctcaaa   7080

ttgtagatat agggtaatca ataaaatcca tccatgcctt tcacacacta agt          7133


<210>  4807
<211>  872
<212>  PRT
<213>  Homo sapiens

<400>  4807

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro 
        515                 520                 525


Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu 
    530                 535                 540


Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu 
545                 550                 555                 560


Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro 
                565                 570                 575


Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn 
            580                 585                 590


Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn 
        595                 600                 605


Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn 
    610                 615                 620


Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser 
625                 630                 635                 640


Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp 
                645                 650                 655


Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn 
            660                 665                 670


Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro 
        675                 680                 685


Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu 
    690                 695                 700


Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg 
705                 710                 715                 720


Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys 
                725                 730                 735


Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys 
            740                 745                 750


Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala 
        755                 760                 765


Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp 
    770                 775                 780


Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu 
785                 790                 795                 800


Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met 
                805                 810                 815


Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly 
            820                 825                 830


Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro 
        835                 840                 845


Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu 
    850                 855                 860


Phe Ile Lys Phe Thr Val Ile Arg 
865                 870


<210>  4808
<211>  4202
<212>  DNA
<213>  Homo sapiens

<400>  4808
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagc tcaagctctt ggactcaccg   2040

aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag   2100

gcttgccaga ggggattccc ttccgaagcc ctacctggtt tggaattcca cgacttgaaa   2160

ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt   2220

cctacttgcc tcctgggatg gctagtaaaa taaacactaa agctttgcag tcccccaaaa   2280

gaccacgaag tcctgggagt aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc   2340

ctaataacaa caatcctcaa acctcagctg ttcgaacccc gacccagact aacggttcta   2400

acgttccctt caagccacga gggagagagt tttcctttga ggcctggaat gccaaaatca   2460

cggacctaaa acagaaagtt gaaaatctct tcaatgagaa atgtggggaa gctcttggcc   2520

ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc tttcccggaa gacttttatg   2580

tggaaggctt acctgagggt gtgccattcc gaagaccatc gacttttggc attccgaggc   2640

tggagaagat actcagaaac aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt   2700

ttgagacggc gattaaggag agcacctcct ctaagagccc tcccagaaaa ataaattcat   2760

cacccaatgt taatactact gcatcaggtg ttgaagacct taacatcatt caggtgacaa   2820

ttccagatga tgataatgaa agactctcga aagttgaaaa agctagacag ctaagagaac   2880

aagtgaatga cctctttagt cggaaatttg gtgaagctat tggtatgggt tttcctgtga   2940

aagttcccta caggaaaatc acaattaacc ctggctgtgt ggtggttgat ggcatgcccc   3000

cgggggtgtc cttcaaagcc cccagctacc tggaaatcag ctccatgaga aggatcttag   3060

actctgccga gtttatcaaa ttcacggtca ttagaccatt tccaggactt gtgattaata   3120

accagctggt tgatcagagt gagtcagaag gccccgtgat acaagaatca gctgaaccaa   3180

gccagttgga agttccagcc acagaagaaa taaaagagac tgatggaagc tctcagatca   3240

agcaagaacc agaccccacg tggtagacct cttccctcct aggcttaaag tatcagtggt   3300

tgagaagagc ttttcggacc tgttactacc ccaagctgta gccttgagtt acggtgttta   3360

ttttccaatc aagtgaagat atctcctact tctcctactg gaacatctca gcttctgcag   3420

tgaagaaaaa ttcctgtgat agttcagttc tttagttttt ctatttgaaa aaaaaaaatc   3480

atttaaatga tcctttgttc acggctctcc ttaatgactg agtgaacagt tcctatctgt   3540

atatttgact aaaccttttc ctaagctatc tctcatggtt cctatgtttt tttatcataa   3600

ttaaaagcaa aaccatctgg atcacctaac agtcagaggt cagtatctca gcgtgtgaat   3660

tatagaggaa atacagagag aacctcttcc acttttactt ttcgtccaaa taaaatgcat   3720

ggtgtaccag aagttgaaga tcgggttgag gattggggct agctcgatga cactaaggcc   3780

ccaacatcgc gggacctgct gtggcgcgga ttcttaggaa cgctgttcta gccggccccc   3840

tctccagggg tcgccgtggc cggcattatt tcctagttct tcttgtaacc ctgaggtgcc   3900

agcgcgggga gtgaggaggg gtcagggggc taaggatgca acctctgacg ttctgcgcct   3960

tcctaggaga gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt aaaataccag   4020

ctctacaaga agctaggctc tgtgacggca tagttttcag tagctttatc acaatattca   4080

caatggagaa ttatatgaca tggtagcaga aataggccct tttatgtgtt gcttctattt   4140

tacctcaaat tgtagatata gggtaatcaa taaaatccat ccatgccttt cacacactaa   4200

gt                                                                  4202


<210>  4809
<211>  954
<212>  PRT
<213>  Homo sapiens

<400>  4809

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly 
    530                 535                 540


Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro 
545                 550                 555                 560


Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser 
                565                 570                 575


Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser 
            580                 585                 590


Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr 
        595                 600                 605


Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser 
    610                 615                 620


Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile 
625                 630                 635                 640


Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala 
                645                 650                 655


Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro 
            660                 665                 670


Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp 
        675                 680                 685


Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala 
    690                 695                 700


Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser 
705                 710                 715                 720


Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe 
                725                 730                 735


Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg 
            740                 745                 750


Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu 
        755                 760                 765


Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile 
    770                 775                 780


Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu 
785                 790                 795                 800


Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser 
                805                 810                 815


Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe 
            820                 825                 830


Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val 
        835                 840                 845


Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly 
    850                 855                 860


Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser 
865                 870                 875                 880


Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val 
                885                 890                 895


Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln 
            900                 905                 910


Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln 
        915                 920                 925


Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser 
    930                 935                 940


Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  4810
<211>  7053
<212>  DNA
<213>  Homo sapiens

<400>  4810
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gctcaagctc ttggactcac cgaggcagta aaagtaccat   1920

atcctgtgtt tgaatcaaac ccggagttct tgtatgtgga aggcttgcca gaggggattc   1980

ccttccgaag ccctacctgg tttggaattc cacgacttga aaggatcgtc cgcgggagta   2040

ataaaatcaa gttcgttgtt aaaaaacctg aactagttat ttcctacttg cctcctggga   2100

tggctagtaa aataaacact aaagctttgc agtcccccaa aagaccacga agtcctggga   2160

gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg ccctaataac aacaatcctc   2220

aaacctcagc tgttcgaacc ccgacccaga ctaacggttc taacgttccc ttcaagccac   2280

gagggagaga gttttccttt gaggcctgga atgccaaaat cacggaccta aaacagaaag   2340

ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg   2400

tgccgttcgc gttatttgag tctttcccgg aagactttta tgtggaaggc ttacctgagg   2460

gtgtgccatt ccgaagacca tcgacttttg gcattccgag gctggagaag atactcagaa   2520

acaaagccaa aattaagttc atcattaaaa agcccgaaat gtttgagacg gcgattaagg   2580

agagcacctc ctctaagagc cctcccagaa aaataaattc atcacccaat gttaatacta   2640

ctgcatcagg tgttgaagac cttaacatca ttcaggtgac aattccagat gatgataatg   2700

aaagactctc gaaagttgaa aaagctagac agctaagaga acaagtgaat gacctcttta   2760

gtcggaaatt tggtgaagct attggtatgg gttttcctgt gaaagttccc tacaggaaaa   2820

tcacaattaa ccctggctgt gtggtggttg atggcatgcc cccgggggtg tccttcaaag   2880

cccccagcta cctggaaatc agctccatga gaaggatctt agactctgcc gagtttatca   2940

aattcacggt cattaggtaa gtgagagttt cctgcttagt cacaggagcg aatctggagc   3000

tcatgaggct gactcttcta aaatgcagcc acaggtagtc atcgaatccg gcttcctatg   3060

ctgtgcaatc aacaaatcaa aataacttgt gtcatcatta gaatgtcaga tgtgcttcta   3120

cgaactaagc tgactctttt aattctttgg caaagggttg gcaaactagg actgtttgcc   3180

aaattcaggc tgcctcctat ttttagagtc ttcctgaaac acagctacac ccgtattatc   3240

catggctgct ttcctgtcac agtgagtaag tagctgggac tgagaaggca tggcctccaa   3300

agtctaaaat atttactctc tagcactttg tagaaaaacc ttagctaggc acagtggcta   3360

acgcctgtaa tcccagcatt ttgggaggcc aaggcaggca gatcacctga ggtcaggagt   3420

tccagaccag cctggccaac atggtgaaat cccatctcta caaaaataaa acagttagct   3480

gggcatgatg gcgggtgcct gtaatcccag ctactcggga ggctgaggca ggatagtcgc   3540

ttgaacccag gaggtggagg ttgcaatgag ccaagatcat gccactgcac tccagcctgg   3600

acgacagagt gagactccat cacaagaaaa aaagaacttt gtcaacctct gtcttagggc   3660

gccttgtcac aggcttcggg tcagacggat tcaaccttgc atcagccatt tgttagccag   3720

gtcactctgt tctttgtctg taaatgagat tgatcgttgt tcccactgag agtgtcagct   3780

ccttcccgta gagcaggcat gatgattgta ctcacctctg acaccattgt gagtgccaca   3840

ttccttccca cgtccttgtc actgtaagag atgcccacct gagcaccaac cccaggttat   3900

cttccccttt gtcttccagc cccccagaaa cagctacgac tcaacctacc caatcatttc   3960

atcatcagat tgccactgtc tctagttcag gtctcttggg actggcactc agaaatctca   4020

taataaatcc tcttgaggct tctcatacac tcgtcttctt ccaatcttct ttccctcaaa   4080

atctcatatt ttggttccac ttcacccacc gtcattctcc atatcactcc caggagttag   4140

gcaaaaagcc ccttccgttc ttccgtatgt taaacttaga atcactctgt tccctgctct   4200

gcgtttctat tttttgtttt tcctccattt actagtagct taacactttc taacagtgtt   4260

cttattattg atacgtatct atctcttcca taagcttata aggtcacgga taatacttct   4320

cattgtagta cgtaaatgac gtgggctaga tatgagttga ataaacagtt atacctgtaa   4380

attcttacag agtgaaaata aattgttata ctttacaatt tgtttctctc tttagaccat   4440

ttccaggact tgtgattaat aaccgtgagt attttgtgaa gtgttttgtt tttgtttttt   4500

cctggggtct gacgtgtgtg cgtgtgagtg tgtatacatg cttaacgtat atcacgttac   4560

ttcacctatg tcagtaacca ggccaaatac ttgttttagc cctcagtaaa aacaccaggc   4620

acttcctagt tgtaaaatta ttcaagcttc ttaacttcct atcctcgatg cacttaatca   4680

taaaatggta ataatagcac cgattttggg ggagtcgttc cagtagatgg aaagcatctg   4740

gaacaggtgt cagcaagctc ctgccgacgt gtatgcataa agttttattg aaaccaccat   4800

cgtgtccatt tgtttatggc agaactgaga gatggcagca gcaagtgtgt gcctgcaaaa   4860

cctaaaatat ttactaattg gctctgcaag aaaagagttt gcatccccct aacctagaac   4920

agtgtctagc ctctagtatg tgtttagcct acagtatgtg ctcagcgaat acaatctata   4980

tttattactg cttttatgac tgttataatt actgtgcttg gatttcgtta caaagtaagt   5040

cacaatgtgc ctgcttctgt tagtatttca gcacagtgcc tggcacacat ggggctctca   5100

aatattgctg agcgagtgaa caaatgtcct ttcaattcct taacgttgat gtcattttca   5160

atagtatttt gagccaaact taattttgcg agtgtgtttt gttttcttaa ctttattatt   5220

aaaaatgtat aaaagtgagg ccaggcgtgg tggctcacgc ctgtaatccc agcagtttgg   5280

gaggctgagg caggcggatc agttgaggtt gggagttgga gaccagcccg tccaacatgg   5340

tgaaagcctg tctctactaa aaatacaaaa atcagctggg tgtggtggcg cgtgcctgta   5400

atcccagcta ctcaggaggc tgaggcagga gagttgcttg aatcctagag gtggaggttg   5460

cagtgagctg agatcgtgcc attgcactcc agcctgggca acaagagcaa aactctgtcc   5520

caataaataa ataaataaaa tgttctcttt tgttcctgtt cttgtgcggt agtgtggtat   5580

agagttttat ggtaattact gtgaattagt gattctgagg gacatatcag aactctgagg   5640

tttgtttcct tctcatcttg agggaaacag caaatgtatg ttaaaatgct tttccaaggg   5700

aacaacacat ccttacatta tttaaaccaa tctgcttcat tttcagagct ggttgatcag   5760

agtgagtcag aaggccccgt gatacaagaa tcagctgaac caagccagtt ggaagttcca   5820

gccacagaag aaataaaaga gactgatgga agctctcaga tcaagcaaga accagacccc   5880

acgtggtaga cctcttccct cctaggctta aagtatcagt ggttgagaag agcttttcgg   5940

acctgttact accccaagct gtgtaatata cttgtataac agaaatacct tctatacaaa   6000

cctttttttc tacttttaga tagaaatgtc tactttttca gcagttctgt gaattaaaga   6060

gcagagtgac tgtgggtctg gaatggctgg tgtacttggg aatgtactat caggatttta   6120

cagcaatgct gggaaatgac agggaaaatg acaggaatga atctcaccag attttttatg   6180

tactcagcag agccttgagt tacggtgttt attttccaat caagtgaaga tatctcctac   6240

ttctcctact ggaacatctc agcttctgca gtgaagaaaa attcctgtga tagttcagtt   6300

ctttagtttt tctatttgaa aaaaaaaaat catttaaatg atcctttgtt cacggctctc   6360

cttaatgact gagtgaacag ttcctatctg tatatttgac taaacctttt cctaagctat   6420

ctctcatggt tcctatgttt ttttatcata attaaaagca aaaccatctg gatcacctaa   6480

cagtcagagg tcagtatctc agcgtgtgaa ttatagagga aatacagaga gaacctcttc   6540

cacttttact tttcgtccaa ataaaatgca tggtgtacca gaagttgaag atcgggttga   6600

ggattggggc tagctcgatg acactaaggc cccaacatcg cgggacctgc tgtggcgcgg   6660

attcttagga acgctgttct agccggcccc ctctccaggg gtcgccgtgg ccggcattat   6720

ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg   6780

ctaaggatgc aacctctgac gttctgcgcc ttcctaggag agtcttacat gtgttgagat   6840

ttcacaagca atgcgagttg taaaatacca gctctacaag aagctaggct ctgtgacggc   6900

atagttttca gtagctttat cacaatattc acaatggaga attatatgac atggtagcag   6960

aaataggccc ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat agggtaatca   7020

ataaaatcca tccatgcctt tcacacacta agt                                7053


<210>  4811
<211>  852
<212>  PRT
<213>  Homo sapiens

<400>  4811

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala 
                485                 490                 495


Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser 
            500                 505                 510


Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        515                 520                 525


Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg 
    530                 535                 540


Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile 
545                 550                 555                 560


Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu 
                565                 570                 575


Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro 
            580                 585                 590


Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr 
        595                 600                 605


Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe 
    610                 615                 620


Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile 
625                 630                 635                 640


Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly 
                645                 650                 655


Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe 
            660                 665                 670


Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val 
        675                 680                 685


Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile 
    690                 695                 700


Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met 
705                 710                 715                 720


Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg 
                725                 730                 735


Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu 
            740                 745                 750


Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg 
        755                 760                 765


Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp 
    770                 775                 780


Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val 
785                 790                 795                 800


Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val 
                805                 810                 815


Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu 
            820                 825                 830


Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe 
        835                 840                 845


Thr Val Ile Arg 
    850


<210>  4812
<211>  5108
<212>  DNA
<213>  Homo sapiens

<400>  4812
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgcttaga tttgttgaca gcggtttcct ggagtgctgt   1980

cttgagaacg attctgagga ggctcagcaa gaaagagtgt ttcagttgat tgggtgtgtc   2040

tgtcatggag aaggaactca agctcttgga ctcaccgagg cagtaaaagt accatatcct   2100

gtgtttgaat caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc   2160

cgaagcccta cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa   2220

atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct   2280

agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat   2340

tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc   2400

tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg   2460

agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa   2520

aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg   2580

ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg   2640

ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa   2700

gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc   2760

acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca   2820

tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga   2880

ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg   2940

aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca   3000

attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt caaagccccc   3060

agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc   3120

acggtcatta gaccatttcc aggacttgtg attaataacc agctggttga tcagagtgag   3180

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   3240

gaaggtaaaa ggacctcttc cctcctaggg taaatcagct tctgtgtcag ggatgctgtg   3300

tggtgtccat ctgaaccccc tgcatacgcg tagctaatgt gatctcccca ctttcacata   3360

agatggtggc cctgccttca gggaatgtgg gagccaggtg ggagccttcc cggatattta   3420

agctagaaga ttctacaggg agattctcct tggatcaata tatgtctctc agtcaaagat   3480

gtaaaagcac ttttgcctta aaaagaatgt tctgtttcta aatagagtca acgttgtcct   3540

cctcattgga attcactatg agtcagaatc attagactga cttttttttt tccatagtaa   3600

tagtattttg cagagtctca cagagctgca gatcttttgt tcatcttgca gagttaacaa   3660

gtctgatcct gttagtccag atttcttaaa tttggccaag ttataatagg agcagtagct   3720

tgagacccga agtcaggaaa ctttgacaat ggattttttt ttttaatcca gagacttgta   3780

ctggaatttg ccttaccctg tcagctcatg gacttaaggt ttcatcccgc tttatgagtg   3840

cttctgaatc caagtcattg ttacctgaat ttgcaaatta agttgtgata ttcgtgactg   3900

ttaaattcct gtaattagat taacctcttt gcttgcttgt ttgttttctc tcctatttta   3960

gcttaaagta tcagtggttg agaagagctt ttcggacctg ttactacccc aagctgtgta   4020

atatacttgt ataacagaaa taccttctat acaaaccttt ttttctactt ttagatagaa   4080

atgtctactt tttcagcagt tctgtgaatt aaagagcaga gtgactgtgg gtctggaatg   4140

gctggtgtac ttgggaatgt actatcagga ttttacagca atgctgggaa atgacaggga   4200

aaatgacagg aatgaatctc accagatttt ttatgtactc agcagagcct tgagttacgg   4260

tgtttatttt ccaatcaagt gaagatatct cctacttctc ctactggaac atctcagctt   4320

ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa   4380

aaaatcattt aaatgatcct ttgttcacgg ctctccttaa tgactgagtg aacagttcct   4440

atctgtatat ttgactaaac cttttcctaa gctatctctc atggttccta tgttttttta   4500

tcataattaa aagcaaaacc atctggatca cctaacagtc agaggtcagt atctcagcgt   4560

gtgaattata gaggaaatac agagagaacc tcttccactt ttacttttcg tccaaataaa   4620

atgcatggtg taccagaagt tgaagatcgg gttgaggatt ggggctagct cgatgacact   4680

aaggccccaa catcgcggga cctgctgtgg cgcggattct taggaacgct gttctagccg   4740

gccccctctc caggggtcgc cgtggccggc attatttcct agttcttctt gtaaccctga   4800

ggtgccagcg cggggagtga ggaggggtca gggggctaag gatgcaacct ctgacgttct   4860

gcgccttcct aggagagtct tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa   4920

taccagctct acaagaagct aggctctgtg acggcatagt tttcagtagc tttatcacaa   4980

tattcacaat ggagaattat atgacatggt agcagaaata ggccctttta tgtgttgctt   5040

ctattttacc tcaaattgta gatatagggt aatcaataaa atccatccat gcctttcaca   5100

cactaagt                                                            5108


<210>  4813
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  4813

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
            420                 425                 430


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
        435                 440                 445


Phe Asn Leu Lys Phe Ala 
    450


<210>  4814
<211>  4377
<212>  DNA
<213>  Homo sapiens

<400>  4814
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gtcaaagaag attggaatgt   1980

cagaattacc aagctacgga agcaagtgga agagattttt aatttgaaat ttgctcaagc   2040

tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt   2100

cttgaaagga tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa acctgaacta   2160

gttatttcct acttgcctcc tgggatggct agtaaaataa acactaaagc tttgcagtcc   2220

cccaaaagac cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg   2280

gaaggcccta ataacaacaa tcctcaaacc tcagctgttc gaaccccgac ccagactaac   2340

ggttctaacg ttcccttcaa gccacgaggg agagagtttt cctttgaggc ctggaatgcc   2400

aaaatcacgg acctaaaaca gaaagttgaa aatctcttca atgagaaatg tggggaagct   2460

cttggcctta aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac   2520

ttttatgtgg aaggcttacc tgagggtgtg ccattccgaa gaccatcgac ttttggcatt   2580

ccgaggctgg agaagatact cagaaacaaa gccaaaatta agttcatcat taaaaagccc   2640

gaaatgtttg agacggcgat taaggagagc acctcctcta agagccctcc cagaaaaata   2700

aattcatcac ccaatgttaa tactactgca tcaggtgttg aagaccttaa catcattcag   2760

gtgacaattc cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta   2820

agagaacaag tgaatgacct ctttagtcgg aaatttggtg aagctattgg tatgggtttt   2880

cctgtgaaag ttccctacag gaaaatcaca attaaccctg gctgtgtggt ggttgatggc   2940

atgcccccgg gggtgtcctt caaagccccc agctacctgg aaatcagctc catgagaagg   3000

atcttagact ctgccgagtt tatcaaattc acggtcatta gaccatttcc aggacttgtg   3060

attaataacc agctggttga tcagagtgag tcagaaggcc ccgtgataca agaatcagct   3120

gaaccaagcc agttggaagt tccagccaca gaagaaataa aagagactga tggaagctct   3180

cagatcaagc aagaaccaga ccccacgtgg tagacctctt ccctcctagg cttaaagtat   3240

cagtggttga gaagagcttt tcggacctgt tactacccca agctgtgtaa tatacttgta   3300

taacagaaat accttctata caaacctttt tttctacttt tagatagaaa tgtctacttt   3360

ttcagcagtt ctgtgaatta aagagcagag tgactgtggg tctggaatgg ctggtgtact   3420

tgggaatgta ctatcaggat tttacagcaa tgctgggaaa tgacagggaa aatgacagga   3480

atgaatctca ccagattttt tatgtactca gcagagcctt gagttacggt gtttattttc   3540

caatcaagtg aagatatctc ctacttctcc tactggaaca tctcagcttc tgcagtgaag   3600

aaaaattcct gtgatagttc agttctttag tttttctatt tgaaaaaaaa aaatcattta   3660

aatgatcctt tgttcacggc tctccttaat gactgagtga acagttccta tctgtatatt   3720

tgactaaacc ttttcctaag ctatctctca tggttcctat gtttttttat cataattaaa   3780

agcaaaacca tctggatcac ctaacagtca gaggtcagta tctcagcgtg tgaattatag   3840

aggaaataca gagagaacct cttccacttt tacttttcgt ccaaataaaa tgcatggtgt   3900

accagaagtt gaagatcggg ttgaggattg gggctagctc gatgacacta aggccccaac   3960

atcgcgggac ctgctgtggc gcggattctt aggaacgctg ttctagccgg ccccctctcc   4020

aggggtcgcc gtggccggca ttatttccta gttcttcttg taaccctgag gtgccagcgc   4080

ggggagtgag gaggggtcag ggggctaagg atgcaacctc tgacgttctg cgccttccta   4140

ggagagtctt acatgtgttg agatttcaca agcaatgcga gttgtaaaat accagctcta   4200

caagaagcta ggctctgtga cggcatagtt ttcagtagct ttatcacaat attcacaatg   4260

gagaattata tgacatggta gcagaaatag gcccttttat gtgttgcttc tattttacct   4320

caaattgtag atatagggta atcaataaaa tccatccatg cctttcacac actaagt      4377


<210>  4815
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  4815

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys 
                565                 570                 575


Asn Leu Asn 



<210>  4816
<211>  4439
<212>  DNA
<213>  Homo sapiens

<400>  4816
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1980

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   2040

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttgt   2100

atgtggaagg cttgccagag gggattccct tccgaagccc tacctggttt ggaattccac   2160

gacttgaaag gatcgtccgc gggagtaata aaatcaagtt cgttgttaaa aaacctgaac   2220

tagttatttc ctacttgcct cctgggatgg ctagtaaaat aaacactaaa gctttgcagt   2280

cccccaaaag accacgaagt cctgggagta attcaaaggt tcctgaaatt gaggtcaccg   2340

tggaaggccc taataacaac aatcctcaaa cctcagctgt tcgaaccccg acccagacta   2400

acggttctaa cgttcccttc aagccacgag ggagagagtt ttcctttgag gcctggaatg   2460

ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt caatgagaaa tgtggggaag   2520

ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt atttgagtct ttcccggaag   2580

acttttatgt ggaaggctta cctgagggtg tgccattccg aagaccatcg acttttggca   2640

ttccgaggct ggagaagata ctcagaaaca aagccaaaat taagttcatc attaaaaagc   2700

ccgaaatgtt tgagacggcg attaaggaga gcacctcctc taagagccct cccagaaaaa   2760

taaattcatc acccaatgtt aatactactg catcaggtgt tgaagacctt aacatcattc   2820

aggtgacaat tccagatgat gataatgaaa gactctcgaa agttgaaaaa gctagacagc   2880

taagagaaca agtgaatgac ctctttagtc ggaaatttgg tgaagctatt ggtatgggtt   2940

ttcctgtgaa agttccctac aggaaaatca caattaaccc tggctgtgtg gtggttgatg   3000

gcatgccccc gggggtgtcc ttcaaagccc ccagctacct ggaaatcagc tccatgagaa   3060

ggatcttaga ctctgccgag tttatcaaat tcacggtcat tagaccattt ccaggacttg   3120

tgattaataa ccagctggtt gatcagagtg agtcagaagg ccccgtgata caagaatcag   3180

ctgaaccaag ccagttggaa gttccagcca cagaagaaat aaaagagact gatggaagct   3240

ctcagatcaa gcaagaacca gaccccacgt ggtagacctc ttccctccta ggcttaaagt   3300

atcagtggtt gagaagagct tttcggacct gttactaccc caagctgtgt aatatacttg   3360

tataacagaa ataccttcta tacaaacctt tttttctact tttagataga aatgtctact   3420

ttttcagcag ttctgtgaat taaagagcag agtgactgtg ggtctggaat ggctggtgta   3480

cttgggaatg tactatcagg attttacagc aatgctggga aatgacaggg aaaatgacag   3540

gaatgaatct caccagattt tttatgtact cagcagagcc ttgagttacg gtgtttattt   3600

tccaatcaag tgaagatatc tcctacttct cctactggaa catctcagct tctgcagtga   3660

agaaaaattc ctgtgatagt tcagttcttt agtttttcta tttgaaaaaa aaaaatcatt   3720

taaatgatcc tttgttcacg gctctcctta atgactgagt gaacagttcc tatctgtata   3780

tttgactaaa ccttttccta agctatctct catggttcct atgttttttt atcataatta   3840

aaagcaaaac catctggatc acctaacagt cagaggtcag tatctcagcg tgtgaattat   3900

agaggaaata cagagagaac ctcttccact tttacttttc gtccaaataa aatgcatggt   3960

gtaccagaag ttgaagatcg ggttgaggat tggggctagc tcgatgacac taaggcccca   4020

acatcgcggg acctgctgtg gcgcggattc ttaggaacgc tgttctagcc ggccccctct   4080

ccaggggtcg ccgtggccgg cattatttcc tagttcttct tgtaaccctg aggtgccagc   4140

gcggggagtg aggaggggtc agggggctaa ggatgcaacc tctgacgttc tgcgccttcc   4200

taggagagtc ttacatgtgt tgagatttca caagcaatgc gagttgtaaa ataccagctc   4260

tacaagaagc taggctctgt gacggcatag ttttcagtag ctttatcaca atattcacaa   4320

tggagaatta tatgacatgg tagcagaaat aggccctttt atgtgttgct tctattttac   4380

ctcaaattgt agatataggg taatcaataa aatccatcca tgcctttcac acactaagt    4439


<210>  4817
<211>  957
<212>  PRT
<213>  Homo sapiens

<400>  4817

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
                565                 570                 575


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
            580                 585                 590


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
        595                 600                 605


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
    610                 615                 620


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
625                 630                 635                 640


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
                645                 650                 655


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
            660                 665                 670


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
        675                 680                 685


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
    690                 695                 700


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
705                 710                 715                 720


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
                725                 730                 735


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
            740                 745                 750


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
        755                 760                 765


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
    770                 775                 780


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
785                 790                 795                 800


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
                805                 810                 815


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
            820                 825                 830


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
        835                 840                 845


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
    850                 855                 860


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
865                 870                 875                 880


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
                885                 890                 895


Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu 
            900                 905                 910


Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu 
        915                 920                 925


Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp 
    930                 935                 940


Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950                 955


<210>  4818
<211>  4227
<212>  DNA
<213>  Homo sapiens

<400>  4818
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2040

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2100

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2160

tgaatcaaac ccggagttct tgaaaggatc gtccgcggga gtaataaaat caagttcgtt   2220

gttaaaaaac ctgaactagt tatttcctac ttgcctcctg ggatggctag taaaataaac   2280

actaaagctt tgcagtcccc caaaagacca cgaagtcctg ggagtaattc aaaggttcct   2340

gaaattgagg tcaccgtgga aggccctaat aacaacaatc ctcaaacctc agctgttcga   2400

accccgaccc agactaacgg ttctaacgtt cccttcaagc cacgagggag agagttttcc   2460

tttgaggcct ggaatgccaa aatcacggac ctaaaacaga aagttgaaaa tctcttcaat   2520

gagaaatgtg gggaagctct tggccttaaa caagctgtga aggtgccgtt cgcgttattt   2580

gagtctttcc cggaagactt ttatgtggaa ggcttacctg agggtgtgcc attccgaaga   2640

ccatcgactt ttggcattcc gaggctggag aagatactca gaaacaaagc caaaattaag   2700

ttcatcatta aaaagcccga aatgtttgag acggcgatta aggagagcac ctcctctaag   2760

agccctccca gaaaaataaa ttcatcaccc aatgttaata ctactgcatc aggtgttgaa   2820

gaccttaaca tcattcaggt gacaattcca gatgatgata atgaaagact ctcgaaagtt   2880

gaaaaagcta gacagctaag agaacaagtg aatgacctct ttagtcggaa atttggtgaa   2940

gctattggta tgggttttcc tgtgaaagtt ccctacagga aaatcacaat taaccctggc   3000

tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca aagcccccag ctacctggaa   3060

atcagctcca tgagaaggat cttagactct gccgagttta tcaaattcac ggtcattaga   3120

ccatttccag gacttgtgat taataaccag ctggttgatc agagtgagtc agaaggcccc   3180

gtgatacaag aatcagctga accaagccag ttggaagttc cagccacaga agaaataaaa   3240

gagactgatg gaagctctca gatcaagcaa gaaccagacc ccacgtggta gacctcttcc   3300

ctcctaggct taaagtatca gtggttgaga agagcttttc ggacctgtta ctaccccaag   3360

ctgtagcctt gagttacggt gtttattttc caatcaagtg aagatatctc ctacttctcc   3420

tactggaaca tctcagcttc tgcagtgaag aaaaattcct gtgatagttc agttctttag   3480

tttttctatt tgaaaaaaaa aaatcattta aatgatcctt tgttcacggc tctccttaat   3540

gactgagtga acagttccta tctgtatatt tgactaaacc ttttcctaag ctatctctca   3600

tggttcctat gtttttttat cataattaaa agcaaaacca tctggatcac ctaacagtca   3660

gaggtcagta tctcagcgtg tgaattatag aggaaataca gagagaacct cttccacttt   3720

tacttttcgt ccaaataaaa tgcatggtgt accagaagtt gaagatcggg ttgaggattg   3780

gggctagctc gatgacacta aggccccaac atcgcgggac ctgctgtggc gcggattctt   3840

aggaacgctg ttctagccgg ccccctctcc aggggtcgcc gtggccggca ttatttccta   3900

gttcttcttg taaccctgag gtgccagcgc ggggagtgag gaggggtcag ggggctaagg   3960

atgcaacctc tgacgttctg cgccttccta ggagagtctt acatgtgttg agatttcaca   4020

agcaatgcga gttgtaaaat accagctcta caagaagcta ggctctgtga cggcatagtt   4080

ttcagtagct ttatcacaat attcacaatg gagaattata tgacatggta gcagaaatag   4140

gcccttttat gtgttgcttc tattttacct caaattgtag atatagggta atcaataaaa   4200

tccatccatg cctttcacac actaagt                                       4227


<210>  4819
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  4819

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala 
            580                 585                 590


Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600                 605


<210>  4820
<211>  3736
<212>  DNA
<213>  Homo sapiens

<400>  4820
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1980

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   2040

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2100

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2160

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2220

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2280

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2340

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2400

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2460

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2520

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2580

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2640

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2700

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2760

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2820

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2880

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   2940

cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg atcagagtga   3000

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   3060

agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag accccacgtg   3120

gtagacctct tccctcctag gcaaaaccat ctggatcacc taacagtcag aggtcagtat   3180

ctcagcgtgt gaattataga ggaaatacag agagaacctc ttccactttt acttttcgtc   3240

caaataaaat gcatggtgta ccagaagttg aagatcgggt tgaggattgg ggctagctcg   3300

atgacactaa ggccccaaca tcgcgggacc tgctgtggcg cggattctta ggaacgctgt   3360

tctagccggc cccctctcca ggggtcgccg tggccggcat tatttcctag ttcttcttgt   3420

aaccctgagg tgccagcgcg gggagtgagg aggggtcagg gggctaagga tgcaacctct   3480

gacgttctgc gccttcctag gagagtctta catgtgttga gatttcacaa gcaatgcgag   3540

ttgtaaaata ccagctctac aagaagctag gctctgtgac ggcatagttt tcagtagctt   3600

tatcacaata ttcacaatgg agaattatat gacatggtag cagaaatagg cccttttatg   3660

tgttgcttct attttacctc aaattgtaga tatagggtaa tcaataaaat ccatccatgc   3720

ctttcacaca ctaagt                                                   3736


<210>  4821
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  4821

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
            420                 425                 430


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
        435                 440                 445


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
    450                 455                 460


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser 
465                 470                 475                 480


Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
                485                 490                 495


<210>  4822
<211>  7750
<212>  DNA
<213>  Homo sapiens

<400>  4822
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gtcaaagaag attggaatgt cagaattacc aagctacgga   1920

agcaagtgga agagattttt aatttgaaat ttgctcaagc tcttggactc accgaggcag   1980

taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgaaagga tcgtccgcgg   2040

gagtaataaa atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc   2100

tgggatggct agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc   2160

tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa   2220

tcctcaaacc tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa   2280

gccacgaggg agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca   2340

gaaagttgaa aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt   2400

gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc   2460

tgagggtgtg ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact   2520

cagaaacaaa gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat   2580

taaggagagc acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa   2640

tactactgca tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga   2700

taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct   2760

ctttagtcgg aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag   2820

gaaaatcaca attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt   2880

caaagccccc agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt   2940

tatcaaattc acggtcatta ggtaagtgag agtttcctgc ttagtcacag gagcgaatct   3000

ggagctcatg aggctgactc ttctaaaatg cagccacagg tagtcatcga atccggcttc   3060

ctatgctgtg caatcaacaa atcaaaataa cttgtgtcat cattagaatg tcagatgtgc   3120

ttctacgaac taagctgact cttttaattc tttggcaaag ggttggcaaa ctaggactgt   3180

ttgccaaatt caggctgcct cctattttta gagtcttcct gaaacacagc tacacccgta   3240

ttatccatgg ctgctttcct gtcacagtga gtaagtagct gggactgaga aggcatggcc   3300

tccaaagtct aaaatattta ctctctagca ctttgtagaa aaaccttagc taggcacagt   3360

ggctaacgcc tgtaatccca gcattttggg aggccaaggc aggcagatca cctgaggtca   3420

ggagttccag accagcctgg ccaacatggt gaaatcccat ctctacaaaa ataaaacagt   3480

tagctgggca tgatggcggg tgcctgtaat cccagctact cgggaggctg aggcaggata   3540

gtcgcttgaa cccaggaggt ggaggttgca atgagccaag atcatgccac tgcactccag   3600

cctggacgac agagtgagac tccatcacaa gaaaaaaaga actttgtcaa cctctgtctt   3660

agggcgcctt gtcacaggct tcgggtcaga cggattcaac cttgcatcag ccatttgtta   3720

gccaggtcac tctgttcttt gtctgtaaat gagattgatc gttgttccca ctgagagtgt   3780

cagctccttc ccgtagagca ggcatgatga ttgtactcac ctctgacacc attgtgagtg   3840

ccacattcct tcccacgtcc ttgtcactgt aagagatgcc cacctgagca ccaaccccag   3900

gttatcttcc cctttgtctt ccagcccccc agaaacagct acgactcaac ctacccaatc   3960

atttcatcat cagattgcca ctgtctctag ttcaggtctc ttgggactgg cactcagaaa   4020

tctcataata aatcctcttg aggcttctca tacactcgtc ttcttccaat cttctttccc   4080

tcaaaatctc atattttggt tccacttcac ccaccgtcat tctccatatc actcccagga   4140

gttaggcaaa aagccccttc cgttcttccg tatgttaaac ttagaatcac tctgttccct   4200

gctctgcgtt tctatttttt gtttttcctc catttactag tagcttaaca ctttctaaca   4260

gtgttcttat tattgatacg tatctatctc ttccataagc ttataaggtc acggataata   4320

cttctcattg tagtacgtaa atgacgtggg ctagatatga gttgaataaa cagttatacc   4380

tgtaaattct tacagagtga aaataaattg ttatacttta caatttgttt ctctctttag   4440

accatttcca ggacttgtga ttaataaccg tgagtatttt gtgaagtgtt ttgtttttgt   4500

tttttcctgg ggtctgacgt gtgtgcgtgt gagtgtgtat acatgcttaa cgtatatcac   4560

gttacttcac ctatgtcagt aaccaggcca aatacttgtt ttagccctca gtaaaaacac   4620

caggcacttc ctagttgtaa aattattcaa gcttcttaac ttcctatcct cgatgcactt   4680

aatcataaaa tggtaataat agcaccgatt ttgggggagt cgttccagta gatggaaagc   4740

atctggaaca ggtgtcagca agctcctgcc gacgtgtatg cataaagttt tattgaaacc   4800

accatcgtgt ccatttgttt atggcagaac tgagagatgg cagcagcaag tgtgtgcctg   4860

caaaacctaa aatatttact aattggctct gcaagaaaag agtttgcatc cccctaacct   4920

agaacagtgt ctagcctcta gtatgtgttt agcctacagt atgtgctcag cgaatacaat   4980

ctatatttat tactgctttt atgactgtta taattactgt gcttggattt cgttacaaag   5040

taagtcacaa tgtgcctgct tctgttagta tttcagcaca gtgcctggca cacatggggc   5100

tctcaaatat tgctgagcga gtgaacaaat gtcctttcaa ttccttaacg ttgatgtcat   5160

tttcaatagt attttgagcc aaacttaatt ttgcgagtgt gttttgtttt cttaacttta   5220

ttattaaaaa tgtataaaag tgaggccagg cgtggtggct cacgcctgta atcccagcag   5280

tttgggaggc tgaggcaggc ggatcagttg aggttgggag ttggagacca gcccgtccaa   5340

catggtgaaa gcctgtctct actaaaaata caaaaatcag ctgggtgtgg tggcgcgtgc   5400

ctgtaatccc agctactcag gaggctgagg caggagagtt gcttgaatcc tagaggtgga   5460

ggttgcagtg agctgagatc gtgccattgc actccagcct gggcaacaag agcaaaactc   5520

tgtcccaata aataaataaa taaaatgttc tcttttgttc ctgttcttgt gcggtagtgt   5580

ggtatagagt tttatggtaa ttactgtgaa ttagtgattc tgagggacat atcagaactc   5640

tgaggtttgt ttccttctca tcttgaggga aacagcaaat gtatgttaaa atgcttttcc   5700

aagggaacaa cacatcctta cattatttaa accaatctgc ttcattttca gagctggttg   5760

atcagagtga gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag   5820

ttccagccac agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag   5880

accccacgtg gtagacctct tccctcctag ggtaaatcag cttctgtgtc agggatgctg   5940

tgtggtgtcc atctgaaccc cctgcatacg cgtagctaat gtgatctccc cactttcaca   6000

taagatggtg gccctgcctt cagggaatgt gggagccagg tgggagcctt cccggatatt   6060

taagctagaa gattctacag ggagattctc cttggatcaa tatatgtctc tcagtcaaag   6120

atgtaaaagc acttttgcct taaaaagaat gttctgtttc taaatagagt caacgttgtc   6180

ctcctcattg gaattcacta tgagtcagaa tcattagact gacttttttt tttccatagt   6240

aatagtattt tgcagagtct cacagagctg cagatctttt gttcatcttg cagagttaac   6300

aagtctgatc ctgttagtcc agatttctta aatttggcca agttataata ggagcagtag   6360

cttgagaccc gaagtcagga aactttgaca atggattttt ttttttaatc cagagacttg   6420

tactggaatt tgccttaccc tgtcagctca tggacttaag gtttcatccc gctttatgag   6480

tgcttctgaa tccaagtcat tgttacctga atttgcaaat taagttgtga tattcgtgac   6540

tgttaaattc ctgtaattag attaacctct ttgcttgctt gtttgttttc tctcctattt   6600

tagcttaaag tatcagtggt tgagaagagc ttttcggacc tgttactacc ccaagctgtg   6660

taatatactt gtataacaga aataccttct atacaaacct ttttttctac ttttagatag   6720

aaatgtctac tttttcagca gttctgtgaa ttaaagagca gagtgactgt gggtctggaa   6780

tggctggtgt acttgggaat gtactatcag gattttacag caatgctggg aaatgacagg   6840

gaaaatgaca ggaatgaatc tcaccagatt ttttatgtac tcagcagagc cttgagttac   6900

ggtgtttatt ttccaatcaa gtgaagatat ctcctacttc tcctactgga acatctcagc   6960

ttctgcagtg aagaaaaatt cctgtgatag ttcagttctt tagtttttct atttgaaaaa   7020

aaaaaatcat ttaaatgatc ctttgttcac ggctctcctt aatgactgag tgaacagttc   7080

ctatctgtat atttgactaa accttttcct aagctatctc tcatggttcc tatgtttttt   7140

tatcataatt aaaagcaaaa ccatctggat cacctaacag tcagaggtca gtatctcagc   7200

gtgtgaatta tagaggaaat acagagagaa cctcttccac ttttactttt cgtccaaata   7260

aaatgcatgg tgtaccagaa gttgaagatc gggttgagga ttggggctag ctcgatgaca   7320

ctaaggcccc aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg ctgttctagc   7380

cggccccctc tccaggggtc gccgtggccg gcattatttc ctagttcttc ttgtaaccct   7440

gaggtgccag cgcggggagt gaggaggggt cagggggcta aggatgcaac ctctgacgtt   7500

ctgcgccttc ctaggagagt cttacatgtg ttgagatttc acaagcaatg cgagttgtaa   7560

aataccagct ctacaagaag ctaggctctg tgacggcata gttttcagta gctttatcac   7620

aatattcaca atggagaatt atatgacatg gtagcagaaa taggcccttt tatgtgttgc   7680

ttctatttta cctcaaattg tagatatagg gtaatcaata aaatccatcc atgcctttca   7740

cacactaagt                                                          7750


<210>  4823
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  4823

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
                485                 490                 495


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
            500                 505                 510


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
        515                 520                 525


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser 
    530                 535                 540


Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
545                 550                 555


<210>  4824
<211>  5143
<212>  DNA
<213>  Homo sapiens

<400>  4824
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   2040

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2100

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2160

tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg tttggaattc   2220

cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg   2280

aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc   2340

agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca   2400

ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga   2460

ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga   2520

atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg   2580

aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg   2640

aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg   2700

gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa   2760

agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa   2820

aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca   2880

ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac   2940

agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg   3000

gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg   3060

atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga   3120

gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca tttccaggac   3180

ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat   3240

cagctgaacc aagccagttg gaagttccag ccacagaagg taaaaggacc tcttccctcc   3300

tagggtaaat cagcttctgt gtcagggatg ctgtgtggtg tccatctgaa ccccctgcat   3360

acgcgtagct aatgtgatct ccccactttc acataagatg gtggccctgc cttcagggaa   3420

tgtgggagcc aggtgggagc cttcccggat atttaagcta gaagattcta cagggagatt   3480

ctccttggat caatatatgt ctctcagtca aagatgtaaa agcacttttg ccttaaaaag   3540

aatgttctgt ttctaaatag agtcaacgtt gtcctcctca ttggaattca ctatgagtca   3600

gaatcattag actgactttt ttttttccat agtaatagta ttttgcagag tctcacagag   3660

ctgcagatct tttgttcatc ttgcagagtt aacaagtctg atcctgttag tccagatttc   3720

ttaaatttgg ccaagttata ataggagcag tagcttgaga cccgaagtca ggaaactttg   3780

acaatggatt ttttttttta atccagagac ttgtactgga atttgcctta ccctgtcagc   3840

tcatggactt aaggtttcat cccgctttat gagtgcttct gaatccaagt cattgttacc   3900

tgaatttgca aattaagttg tgatattcgt gactgttaaa ttcctgtaat tagattaacc   3960

tctttgcttg cttgtttgtt ttctctccta ttttagctta aagtatcagt ggttgagaag   4020

agcttttcgg acctgttact accccaagct gtgtaatata cttgtataac agaaatacct   4080

tctatacaaa cctttttttc tacttttaga tagaaatgtc tactttttca gcagttctgt   4140

gaattaaaga gcagagtgac tgtgggtctg gaatggctgg tgtacttggg aatgtactat   4200

caggatttta cagcaatgct gggaaatgac agggaaaatg acaggaatga atctcaccag   4260

attttttatg tactcagcag agccttgagt tacggtgttt attttccaat caagtgaaga   4320

tatctcctac ttctcctact ggaacatctc agcttctgca gtgaagaaaa attcctgtga   4380

tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat catttaaatg atcctttgtt   4440

cacggctctc cttaatgact gagtgaacag ttcctatctg tatatttgac taaacctttt   4500

cctaagctat ctctcatggt tcctatgttt ttttatcata attaaaagca aaaccatctg   4560

gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa ttatagagga aatacagaga   4620

gaacctcttc cacttttact tttcgtccaa ataaaatgca tggtgtacca gaagttgaag   4680

atcgggttga ggattggggc tagctcgatg acactaaggc cccaacatcg cgggacctgc   4740

tgtggcgcgg attcttagga acgctgttct agccggcccc ctctccaggg gtcgccgtgg   4800

ccggcattat ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg   4860

ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc ttcctaggag agtcttacat   4920

gtgttgagat ttcacaagca atgcgagttg taaaatacca gctctacaag aagctaggct   4980

ctgtgacggc atagttttca gtagctttat cacaatattc acaatggaga attatatgac   5040

atggtagcag aaataggccc ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat   5100

agggtaatca ataaaatcca tccatgcctt tcacacacta agt                     5143


<210>  4825
<211>  968
<212>  PRT
<213>  Homo sapiens

<400>  4825

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu 
            580                 585                 590


Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg 
        595                 600                 605


Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys 
    610                 615                 620


Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys 
625                 630                 635                 640


Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly 
                645                 650                 655


Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn 
            660                 665                 670


Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn 
        675                 680                 685


Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu 
    690                 695                 700


Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu 
705                 710                 715                 720


Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys 
                725                 730                 735


Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu 
            740                 745                 750


Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile 
        755                 760                 765


Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile 
    770                 775                 780


Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser 
785                 790                 795                 800


Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr 
                805                 810                 815


Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro 
            820                 825                 830


Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu 
        835                 840                 845


Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile 
    850                 855                 860


Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn 
865                 870                 875                 880


Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys 
                885                 890                 895


Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser 
            900                 905                 910


Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val 
        915                 920                 925


Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile 
    930                 935                 940


Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Gly 
945                 950                 955                 960


Lys Arg Thr Ser Ser Leu Leu Gly 
                965


<210>  4826
<211>  7804
<212>  DNA
<213>  Homo sapiens

<400>  4826
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040

taccatatcc tgtgtttgaa tcaaacccgg agttcttgaa aggatcgtcc gcgggagtaa   2100

taaaatcaag ttcgttgtta aaaaacctga actagttatt tcctacttgc ctcctgggat   2160

ggctagtaaa ataaacacta aagctttgca gtcccccaaa agaccacgaa gtcctgggag   2220

taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc cctaataaca acaatcctca   2280

aacctcagct gttcgaaccc cgacccagac taacggttct aacgttccct tcaagccacg   2340

agggagagag ttttcctttg aggcctggaa tgccaaaatc acggacctaa aacagaaagt   2400

tgaaaatctc ttcaatgaga aatgtgggga agctcttggc cttaaacaag ctgtgaaggt   2460

gccgttcgcg ttatttgagt ctttcccgga agacttttat gtggaaggct tacctgaggg   2520

tgtgccattc cgaagaccat cgacttttgg cattccgagg ctggagaaga tactcagaaa   2580

caaagccaaa attaagttca tcattaaaaa gcccgaaatg tttgagacgg cgattaagga   2640

gagcacctcc tctaagagcc ctcccagaaa aataaattca tcacccaatg ttaatactac   2700

tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca attccagatg atgataatga   2760

aagactctcg aaagttgaaa aagctagaca gctaagagaa caagtgaatg acctctttag   2820

tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg aaagttccct acaggaaaat   2880

cacaattaac cctggctgtg tggtggttga tggcatgccc ccgggggtgt ccttcaaagc   2940

ccccagctac ctggaaatca gctccatgag aaggatctta gactctgccg agtttatcaa   3000

attcacggtc attaggtaag tgagagtttc ctgcttagtc acaggagcga atctggagct   3060

catgaggctg actcttctaa aatgcagcca caggtagtca tcgaatccgg cttcctatgc   3120

tgtgcaatca acaaatcaaa ataacttgtg tcatcattag aatgtcagat gtgcttctac   3180

gaactaagct gactctttta attctttggc aaagggttgg caaactagga ctgtttgcca   3240

aattcaggct gcctcctatt tttagagtct tcctgaaaca cagctacacc cgtattatcc   3300

atggctgctt tcctgtcaca gtgagtaagt agctgggact gagaaggcat ggcctccaaa   3360

gtctaaaata tttactctct agcactttgt agaaaaacct tagctaggca cagtggctaa   3420

cgcctgtaat cccagcattt tgggaggcca aggcaggcag atcacctgag gtcaggagtt   3480

ccagaccagc ctggccaaca tggtgaaatc ccatctctac aaaaataaaa cagttagctg   3540

ggcatgatgg cgggtgcctg taatcccagc tactcgggag gctgaggcag gatagtcgct   3600

tgaacccagg aggtggaggt tgcaatgagc caagatcatg ccactgcact ccagcctgga   3660

cgacagagtg agactccatc acaagaaaaa aagaactttg tcaacctctg tcttagggcg   3720

ccttgtcaca ggcttcgggt cagacggatt caaccttgca tcagccattt gttagccagg   3780

tcactctgtt ctttgtctgt aaatgagatt gatcgttgtt cccactgaga gtgtcagctc   3840

cttcccgtag agcaggcatg atgattgtac tcacctctga caccattgtg agtgccacat   3900

tccttcccac gtccttgtca ctgtaagaga tgcccacctg agcaccaacc ccaggttatc   3960

ttcccctttg tcttccagcc ccccagaaac agctacgact caacctaccc aatcatttca   4020

tcatcagatt gccactgtct ctagttcagg tctcttggga ctggcactca gaaatctcat   4080

aataaatcct cttgaggctt ctcatacact cgtcttcttc caatcttctt tccctcaaaa   4140

tctcatattt tggttccact tcacccaccg tcattctcca tatcactccc aggagttagg   4200

caaaaagccc cttccgttct tccgtatgtt aaacttagaa tcactctgtt ccctgctctg   4260

cgtttctatt ttttgttttt cctccattta ctagtagctt aacactttct aacagtgttc   4320

ttattattga tacgtatcta tctcttccat aagcttataa ggtcacggat aatacttctc   4380

attgtagtac gtaaatgacg tgggctagat atgagttgaa taaacagtta tacctgtaaa   4440

ttcttacaga gtgaaaataa attgttatac tttacaattt gtttctctct ttagaccatt   4500

tccaggactt gtgattaata accgtgagta ttttgtgaag tgttttgttt ttgttttttc   4560

ctggggtctg acgtgtgtgc gtgtgagtgt gtatacatgc ttaacgtata tcacgttact   4620

tcacctatgt cagtaaccag gccaaatact tgttttagcc ctcagtaaaa acaccaggca   4680

cttcctagtt gtaaaattat tcaagcttct taacttccta tcctcgatgc acttaatcat   4740

aaaatggtaa taatagcacc gattttgggg gagtcgttcc agtagatgga aagcatctgg   4800

aacaggtgtc agcaagctcc tgccgacgtg tatgcataaa gttttattga aaccaccatc   4860

gtgtccattt gtttatggca gaactgagag atggcagcag caagtgtgtg cctgcaaaac   4920

ctaaaatatt tactaattgg ctctgcaaga aaagagtttg catcccccta acctagaaca   4980

gtgtctagcc tctagtatgt gtttagccta cagtatgtgc tcagcgaata caatctatat   5040

ttattactgc ttttatgact gttataatta ctgtgcttgg atttcgttac aaagtaagtc   5100

acaatgtgcc tgcttctgtt agtatttcag cacagtgcct ggcacacatg gggctctcaa   5160

atattgctga gcgagtgaac aaatgtcctt tcaattcctt aacgttgatg tcattttcaa   5220

tagtattttg agccaaactt aattttgcga gtgtgttttg ttttcttaac tttattatta   5280

aaaatgtata aaagtgaggc caggcgtggt ggctcacgcc tgtaatccca gcagtttggg   5340

aggctgaggc aggcggatca gttgaggttg ggagttggag accagcccgt ccaacatggt   5400

gaaagcctgt ctctactaaa aatacaaaaa tcagctgggt gtggtggcgc gtgcctgtaa   5460

tcccagctac tcaggaggct gaggcaggag agttgcttga atcctagagg tggaggttgc   5520

agtgagctga gatcgtgcca ttgcactcca gcctgggcaa caagagcaaa actctgtccc   5580

aataaataaa taaataaaat gttctctttt gttcctgttc ttgtgcggta gtgtggtata   5640

gagttttatg gtaattactg tgaattagtg attctgaggg acatatcaga actctgaggt   5700

ttgtttcctt ctcatcttga gggaaacagc aaatgtatgt taaaatgctt ttccaaggga   5760

acaacacatc cttacattat ttaaaccaat ctgcttcatt ttcagagctg gttgatcaga   5820

gtgagtcaga aggccccgtg atacaagaat cagctgaacc aagccagttg gaagttccag   5880

ccacagaaga aataaaagag actgatggaa gctctcagat caagcaagaa ccagacccca   5940

cgtggtagac ctcttccctc ctagggtaaa tcagcttctg tgtcagggat gctgtgtggt   6000

gtccatctga accccctgca tacgcgtagc taatgtgatc tccccacttt cacataagat   6060

ggtggccctg ccttcaggga atgtgggagc caggtgggag ccttcccgga tatttaagct   6120

agaagattct acagggagat tctccttgga tcaatatatg tctctcagtc aaagatgtaa   6180

aagcactttt gccttaaaaa gaatgttctg tttctaaata gagtcaacgt tgtcctcctc   6240

attggaattc actatgagtc agaatcatta gactgacttt tttttttcca tagtaatagt   6300

attttgcaga gtctcacaga gctgcagatc ttttgttcat cttgcagagt taacaagtct   6360

gatcctgtta gtccagattt cttaaatttg gccaagttat aataggagca gtagcttgag   6420

acccgaagtc aggaaacttt gacaatggat tttttttttt aatccagaga cttgtactgg   6480

aatttgcctt accctgtcag ctcatggact taaggtttca tcccgcttta tgagtgcttc   6540

tgaatccaag tcattgttac ctgaatttgc aaattaagtt gtgatattcg tgactgttaa   6600

attcctgtaa ttagattaac ctctttgctt gcttgtttgt tttctctcct attttagctt   6660

aaagtatcag tggttgagaa gagcttttcg gacctgttac taccccaagc tgtgtaatat   6720

acttgtataa cagaaatacc ttctatacaa accttttttt ctacttttag atagaaatgt   6780

ctactttttc agcagttctg tgaattaaag agcagagtga ctgtgggtct ggaatggctg   6840

gtgtacttgg gaatgtacta tcaggatttt acagcaatgc tgggaaatga cagggaaaat   6900

gacaggaatg aatctcacca gattttttat gtactcagca gagccttgag ttacggtgtt   6960

tattttccaa tcaagtgaag atatctccta cttctcctac tggaacatct cagcttctgc   7020

agtgaagaaa aattcctgtg atagttcagt tctttagttt ttctatttga aaaaaaaaaa   7080

tcatttaaat gatcctttgt tcacggctct ccttaatgac tgagtgaaca gttcctatct   7140

gtatatttga ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt tttttatcat   7200

aattaaaagc aaaaccatct ggatcaccta acagtcagag gtcagtatct cagcgtgtga   7260

attatagagg aaatacagag agaacctctt ccacttttac ttttcgtcca aataaaatgc   7320

atggtgtacc agaagttgaa gatcgggttg aggattgggg ctagctcgat gacactaagg   7380

ccccaacatc gcgggacctg ctgtggcgcg gattcttagg aacgctgttc tagccggccc   7440

cctctccagg ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa ccctgaggtg   7500

ccagcgcggg gagtgaggag gggtcagggg gctaaggatg caacctctga cgttctgcgc   7560

cttcctagga gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc   7620

agctctacaa gaagctaggc tctgtgacgg catagttttc agtagcttta tcacaatatt   7680

cacaatggag aattatatga catggtagca gaaataggcc cttttatgtg ttgcttctat   7740

tttacctcaa attgtagata tagggtaatc aataaaatcc atccatgcct ttcacacact   7800

aagt                                                                7804


<210>  4827
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  4827

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
    450                 455                 460


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
465                 470                 475                 480


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
                485                 490                 495


Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu 
            500                 505                 510


Lys Asn Leu Asn 
        515


<210>  4828
<211>  4476
<212>  DNA
<213>  Homo sapiens

<400>  4828
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gtcaaagaag attggaatgt cagaattacc aagctacgga   1920

agcaagtgga agagattttt aatttgaaat ttgcttagat ttgttgacag cggtttcctg   1980

gagtgctgtc ttgagaacga ttctgaggag gctcagcaag aaagagtgtt tcagttgatt   2040

gggtgtgtct gtcatggaga aggaactcaa gctcttggac tcaccgaggc agtaaaagta   2100

ccatatcctg tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg   2160

attcccttcc gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg   2220

agtaataaaa tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct   2280

gggatggcta gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct   2340

gggagtaatt caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat   2400

cctcaaacct cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag   2460

ccacgaggga gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag   2520

aaagttgaaa atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg   2580

aaggtgccgt tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct   2640

gagggtgtgc cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc   2700

agaaacaaag ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt   2760

aaggagagca cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat   2820

actactgcat caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat   2880

aatgaaagac tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc   2940

tttagtcgga aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg   3000

aaaatcacaa ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc   3060

aaagccccca gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt   3120

atcaaattca cggtcattag accatttcca ggacttgtga ttaataacca gctggttgat   3180

cagagtgagt cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt   3240

ccagccacag aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac   3300

cccacgtggt agacctcttc cctcctaggc ttaaagtatc agtggttgag aagagctttt   3360

cggacctgtt actaccccaa gctgtgtaat atacttgtat aacagaaata ccttctatac   3420

aaaccttttt ttctactttt agatagaaat gtctactttt tcagcagttc tgtgaattaa   3480

agagcagagt gactgtgggt ctggaatggc tggtgtactt gggaatgtac tatcaggatt   3540

ttacagcaat gctgggaaat gacagggaaa atgacaggaa tgaatctcac cagatttttt   3600

atgtactcag cagagccttg agttacggtg tttattttcc aatcaagtga agatatctcc   3660

tacttctcct actggaacat ctcagcttct gcagtgaaga aaaattcctg tgatagttca   3720

gttctttagt ttttctattt gaaaaaaaaa aatcatttaa atgatccttt gttcacggct   3780

ctccttaatg actgagtgaa cagttcctat ctgtatattt gactaaacct tttcctaagc   3840

tatctctcat ggttcctatg tttttttatc ataattaaaa gcaaaaccat ctggatcacc   3900

taacagtcag aggtcagtat ctcagcgtgt gaattataga ggaaatacag agagaacctc   3960

ttccactttt acttttcgtc caaataaaat gcatggtgta ccagaagttg aagatcgggt   4020

tgaggattgg ggctagctcg atgacactaa ggccccaaca tcgcgggacc tgctgtggcg   4080

cggattctta ggaacgctgt tctagccggc cccctctcca ggggtcgccg tggccggcat   4140

tatttcctag ttcttcttgt aaccctgagg tgccagcgcg gggagtgagg aggggtcagg   4200

gggctaagga tgcaacctct gacgttctgc gccttcctag gagagtctta catgtgttga   4260

gatttcacaa gcaatgcgag ttgtaaaata ccagctctac aagaagctag gctctgtgac   4320

ggcatagttt tcagtagctt tatcacaata ttcacaatgg agaattatat gacatggtag   4380

cagaaatagg cccttttatg tgttgcttct attttacctc aaattgtaga tatagggtaa   4440

tcaataaaat ccatccatgc ctttcacaca ctaagt                             4476


<210>  4829
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  4829

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
                485                 490                 495


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
            500                 505                 510


Phe Asn Leu Lys Phe Ala 
        515


<210>  4830
<211>  7317
<212>  DNA
<213>  Homo sapiens

<400>  4830
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gtcaaagaag attggaatgt   1980

cagaattacc aagctacgga agcaagtgga agagattttt aatttgaaat ttgcttagat   2040

ttgttgacag cggtttcctg gagtgctgtc ttgagaacga ttctgaggag gctcagcaag   2100

aaagagtgtt tcagttgatt gggtgtgtct gtcatggaga aggaactcaa gctcttggac   2160

tcaccgaggc agtaaaagta ccatatcctg tgtttgaatc aaacccggag ttcttgtatg   2220

tggaaggctt gccagagggg attcccttcc gaagccctac ctggtttgga attccacgac   2280

ttgaaaggat cgtccgcggg agtaataaaa tcaagttcgt tgttaaaaaa cctgaactag   2340

ttatttccta cttgcctcct gggatggcta gtaaaataaa cactaaagct ttgcagtccc   2400

ccaaaagacc acgaagtcct gggagtaatt caaaggttcc tgaaattgag gtcaccgtgg   2460

aaggccctaa taacaacaat cctcaaacct cagctgttcg aaccccgacc cagactaacg   2520

gttctaacgt tcccttcaag ccacgaggga gagagttttc ctttgaggcc tggaatgcca   2580

aaatcacgga cctaaaacag aaagttgaaa atctcttcaa tgagaaatgt ggggaagctc   2640

ttggccttaa acaagctgtg aaggtgccgt tcgcgttatt tgagtctttc ccggaagact   2700

tttatgtgga aggcttacct gagggtgtgc cattccgaag accatcgact tttggcattc   2760

cgaggctgga gaagatactc agaaacaaag ccaaaattaa gttcatcatt aaaaagcccg   2820

aaatgtttga gacggcgatt aaggagagca cctcctctaa gagccctccc agaaaaataa   2880

attcatcacc caatgttaat actactgcat caggtgttga agaccttaac atcattcagg   2940

tgacaattcc agatgatgat aatgaaagac tctcgaaagt tgaaaaagct agacagctaa   3000

gagaacaagt gaatgacctc tttagtcgga aatttggtga agctattggt atgggttttc   3060

ctgtgaaagt tccctacagg aaaatcacaa ttaaccctgg ctgtgtggtg gttgatggca   3120

tgcccccggg ggtgtccttc aaagccccca gctacctgga aatcagctcc atgagaagga   3180

tcttagactc tgccgagttt atcaaattca cggtcattag gtaagtgaga gtttcctgct   3240

tagtcacagg agcgaatctg gagctcatga ggctgactct tctaaaatgc agccacaggt   3300

agtcatcgaa tccggcttcc tatgctgtgc aatcaacaaa tcaaaataac ttgtgtcatc   3360

attagaatgt cagatgtgct tctacgaact aagctgactc ttttaattct ttggcaaagg   3420

gttggcaaac taggactgtt tgccaaattc aggctgcctc ctatttttag agtcttcctg   3480

aaacacagct acacccgtat tatccatggc tgctttcctg tcacagtgag taagtagctg   3540

ggactgagaa ggcatggcct ccaaagtcta aaatatttac tctctagcac tttgtagaaa   3600

aaccttagct aggcacagtg gctaacgcct gtaatcccag cattttggga ggccaaggca   3660

ggcagatcac ctgaggtcag gagttccaga ccagcctggc caacatggtg aaatcccatc   3720

tctacaaaaa taaaacagtt agctgggcat gatggcgggt gcctgtaatc ccagctactc   3780

gggaggctga ggcaggatag tcgcttgaac ccaggaggtg gaggttgcaa tgagccaaga   3840

tcatgccact gcactccagc ctggacgaca gagtgagact ccatcacaag aaaaaaagaa   3900

ctttgtcaac ctctgtctta gggcgccttg tcacaggctt cgggtcagac ggattcaacc   3960

ttgcatcagc catttgttag ccaggtcact ctgttctttg tctgtaaatg agattgatcg   4020

ttgttcccac tgagagtgtc agctccttcc cgtagagcag gcatgatgat tgtactcacc   4080

tctgacacca ttgtgagtgc cacattcctt cccacgtcct tgtcactgta agagatgccc   4140

acctgagcac caaccccagg ttatcttccc ctttgtcttc cagcccccca gaaacagcta   4200

cgactcaacc tacccaatca tttcatcatc agattgccac tgtctctagt tcaggtctct   4260

tgggactggc actcagaaat ctcataataa atcctcttga ggcttctcat acactcgtct   4320

tcttccaatc ttctttccct caaaatctca tattttggtt ccacttcacc caccgtcatt   4380

ctccatatca ctcccaggag ttaggcaaaa agccccttcc gttcttccgt atgttaaact   4440

tagaatcact ctgttccctg ctctgcgttt ctattttttg tttttcctcc atttactagt   4500

agcttaacac tttctaacag tgttcttatt attgatacgt atctatctct tccataagct   4560

tataaggtca cggataatac ttctcattgt agtacgtaaa tgacgtgggc tagatatgag   4620

ttgaataaac agttatacct gtaaattctt acagagtgaa aataaattgt tatactttac   4680

aatttgtttc tctctttaga ccatttccag gacttgtgat taataaccgt gagtattttg   4740

tgaagtgttt tgtttttgtt ttttcctggg gtctgacgtg tgtgcgtgtg agtgtgtata   4800

catgcttaac gtatatcacg ttacttcacc tatgtcagta accaggccaa atacttgttt   4860

tagccctcag taaaaacacc aggcacttcc tagttgtaaa attattcaag cttcttaact   4920

tcctatcctc gatgcactta atcataaaat ggtaataata gcaccgattt tgggggagtc   4980

gttccagtag atggaaagca tctggaacag gtgtcagcaa gctcctgccg acgtgtatgc   5040

ataaagtttt attgaaacca ccatcgtgtc catttgttta tggcagaact gagagatggc   5100

agcagcaagt gtgtgcctgc aaaacctaaa atatttacta attggctctg caagaaaaga   5160

gtttgcatcc ccctaaccta gaacagtgtc tagcctctag tatgtgttta gcctacagta   5220

tgtgctcagc gaatacaatc tatatttatt actgctttta tgactgttat aattactgtg   5280

cttggatttc gttacaaagt aagtcacaat gtgcctgctt ctgttagtat ttcagcacag   5340

tgcctggcac acatggggct ctcaaatatt gctgagcgag tgaacaaatg tcctttcaat   5400

tccttaacgt tgatgtcatt ttcaatagta ttttgagcca aacttaattt tgcgagtgtg   5460

ttttgttttc ttaactttat tattaaaaat gtataaaagt gaggccaggc gtggtggctc   5520

acgcctgtaa tcccagcagt ttgggaggct gaggcaggcg gatcagttga ggttgggagt   5580

tggagaccag cccgtccaac atggtgaaag cctgtctcta ctaaaaatac aaaaatcagc   5640

tgggtgtggt ggcgcgtgcc tgtaatccca gctactcagg aggctgaggc aggagagttg   5700

cttgaatcct agaggtggag gttgcagtga gctgagatcg tgccattgca ctccagcctg   5760

ggcaacaaga gcaaaactct gtcccaataa ataaataaat aaaatgttct cttttgttcc   5820

tgttcttgtg cggtagtgtg gtatagagtt ttatggtaat tactgtgaat tagtgattct   5880

gagggacata tcagaactct gaggtttgtt tccttctcat cttgagggaa acagcaaatg   5940

tatgttaaaa tgcttttcca agggaacaac acatccttac attatttaaa ccaatctgct   6000

tcattttcag agctggttga tcagagtgag tcagaaggcc ccgtgataca agaatcagct   6060

gaaccaagcc agttggaagt tccagccaca gaagaaataa aagagactga tggaagctct   6120

cagatcaagc aagaaccaga ccccacgtgg tagacctctt ccctcctagg cttaaagtat   6180

cagtggttga gaagagcttt tcggacctgt tactacccca agctgtgtaa tatacttgta   6240

taacagaaat accttctata caaacctttt tttctacttt tagatagaaa tgtctacttt   6300

ttcagcagtt ctgtgaatta aagagcagag tgactgtggg tctggaatgg ctggtgtact   6360

tgggaatgta ctatcaggat tttacagcaa tgctgggaaa tgacagggaa aatgacagga   6420

atgaatctca ccagattttt tatgtactca gcagagcctt gagttacggt gtttattttc   6480

caatcaagtg aagatatctc ctacttctcc tactggaaca tctcagcttc tgcagtgaag   6540

aaaaattcct gtgatagttc agttctttag tttttctatt tgaaaaaaaa aaatcattta   6600

aatgatcctt tgttcacggc tctccttaat gactgagtga acagttccta tctgtatatt   6660

tgactaaacc ttttcctaag ctatctctca tggttcctat gtttttttat cataattaaa   6720

agcaaaacca tctggatcac ctaacagtca gaggtcagta tctcagcgtg tgaattatag   6780

aggaaataca gagagaacct cttccacttt tacttttcgt ccaaataaaa tgcatggtgt   6840

accagaagtt gaagatcggg ttgaggattg gggctagctc gatgacacta aggccccaac   6900

atcgcgggac ctgctgtggc gcggattctt aggaacgctg ttctagccgg ccccctctcc   6960

aggggtcgcc gtggccggca ttatttccta gttcttcttg taaccctgag gtgccagcgc   7020

ggggagtgag gaggggtcag ggggctaagg atgcaacctc tgacgttctg cgccttccta   7080

ggagagtctt acatgtgttg agatttcaca agcaatgcga gttgtaaaat accagctcta   7140

caagaagcta ggctctgtga cggcatagtt ttcagtagct ttatcacaat attcacaatg   7200

gagaattata tgacatggta gcagaaatag gcccttttat gtgttgcttc tattttacct   7260

caaattgtag atatagggta atcaataaaa tccatccatg cctttcacac actaagt      7317


<210>  4831
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  4831

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535


<210>  4832
<211>  5243
<212>  DNA
<213>  Homo sapiens

<400>  4832
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1980

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct tagatttgtt   2040

gacagcggtt tcctggagtg ctgtcttgag aacgattctg aggaggctca gcaagaaaga   2100

gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa ctcaagctct tggactcacc   2160

gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc cggagttctt gtatgtggaa   2220

ggcttgccag aggggattcc cttccgaagc cctacctggt ttggaattcc acgacttgaa   2280

aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta aaaaacctga actagttatt   2340

tcctacttgc ctcctgggat ggctagtaaa ataaacacta aagctttgca gtcccccaaa   2400

agaccacgaa gtcctgggag taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc   2460

cctaataaca acaatcctca aacctcagct gttcgaaccc cgacccagac taacggttct   2520

aacgttccct tcaagccacg agggagagag ttttcctttg aggcctggaa tgccaaaatc   2580

acggacctaa aacagaaagt tgaaaatctc ttcaatgaga aatgtgggga agctcttggc   2640

cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt ctttcccgga agacttttat   2700

gtggaaggct tacctgaggg tgtgccattc cgaagaccat cgacttttgg cattccgagg   2760

ctggagaaga tactcagaaa caaagccaaa attaagttca tcattaaaaa gcccgaaatg   2820

tttgagacgg cgattaagga gagcacctcc tctaagagcc ctcccagaaa aataaattca   2880

tcacccaatg ttaatactac tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca   2940

attccagatg atgataatga aagactctcg aaagttgaaa aagctagaca gctaagagaa   3000

caagtgaatg acctctttag tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg   3060

aaagttccct acaggaaaat cacaattaac cctggctgtg tggtggttga tggcatgccc   3120

ccgggggtgt ccttcaaagc ccccagctac ctggaaatca gctccatgag aaggatctta   3180

gactctgccg agtttatcaa attcacggtc attagaccat ttccaggact tgtgattaat   3240

aaccagctgg ttgatcagag tgagtcagaa ggccccgtga tacaagaatc agctgaacca   3300

agccagttgg aagttccagc cacagaagaa ataaaagaga ctgatggaag ctctcagatc   3360

aagcaagaac cagaccccac gtggtagacc tcttccctcc tagggtaaat cagcttctgt   3420

gtcagggatg ctgtgtggtg tccatctgaa ccccctgcat acgcgtagct aatgtgatct   3480

ccccactttc acataagatg gtggccctgc cttcagggaa tgtgggagcc aggtgggagc   3540

cttcccggat atttaagcta gaagattcta cagggagatt ctccttggat caatatatgt   3600

ctctcagtca aagatgtaaa agcacttttg ccttaaaaag aatgttctgt ttctaaatag   3660

agtcaacgtt gtcctcctca ttggaattca ctatgagtca gaatcattag actgactttt   3720

ttttttccat agtaatagta ttttgcagag tctcacagag ctgcagatct tttgttcatc   3780

ttgcagagtt aacaagtctg atcctgttag tccagatttc ttaaatttgg ccaagttata   3840

ataggagcag tagcttgaga cccgaagtca ggaaactttg acaatggatt ttttttttta   3900

atccagagac ttgtactgga atttgcctta ccctgtcagc tcatggactt aaggtttcat   3960

cccgctttat gagtgcttct gaatccaagt cattgttacc tgaatttgca aattaagttg   4020

tgatattcgt gactgttaaa ttcctgtaat tagattaacc tctttgcttg cttgtttgtt   4080

ttctctccta ttttagctta aagtatcagt ggttgagaag agcttttcgg acctgttact   4140

accccaagct gtgtaatata cttgtataac agaaatacct tctatacaaa cctttttttc   4200

tacttttaga tagaaatgtc tactttttca gcagttctgt gaattaaaga gcagagtgac   4260

tgtgggtctg gaatggctgg tgtacttggg aatgtactat caggatttta cagcaatgct   4320

gggaaatgac agggaaaatg acaggaatga atctcaccag attttttatg tactcagcag   4380

agccttgagt tacggtgttt attttccaat caagtgaaga tatctcctac ttctcctact   4440

ggaacatctc agcttctgca gtgaagaaaa attcctgtga tagttcagtt ctttagtttt   4500

tctatttgaa aaaaaaaaat catttaaatg atcctttgtt cacggctctc cttaatgact   4560

gagtgaacag ttcctatctg tatatttgac taaacctttt cctaagctat ctctcatggt   4620

tcctatgttt ttttatcata attaaaagca aaaccatctg gatcacctaa cagtcagagg   4680

tcagtatctc agcgtgtgaa ttatagagga aatacagaga gaacctcttc cacttttact   4740

tttcgtccaa ataaaatgca tggtgtacca gaagttgaag atcgggttga ggattggggc   4800

tagctcgatg acactaaggc cccaacatcg cgggacctgc tgtggcgcgg attcttagga   4860

acgctgttct agccggcccc ctctccaggg gtcgccgtgg ccggcattat ttcctagttc   4920

ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc   4980

aacctctgac gttctgcgcc ttcctaggag agtcttacat gtgttgagat ttcacaagca   5040

atgcgagttg taaaatacca gctctacaag aagctaggct ctgtgacggc atagttttca   5100

gtagctttat cacaatattc acaatggaga attatatgac atggtagcag aaataggccc   5160

ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat agggtaatca ataaaatcca   5220

tccatgcctt tcacacacta agt                                           5243


<210>  4833
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  4833

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  4834
<211>  7920
<212>  DNA
<213>  Homo sapiens

<400>  4834
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgcttaga tttgttgaca gcggtttcct ggagtgctgt   1980

cttgagaacg attctgagga ggctcagcaa gaaagagtgt ttcagttgat tgggtgtgtc   2040

tgtcatggag aaggaactca agctcttgga ctcaccgagg cagtaaaagt accatatcct   2100

gtgtttgaat caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc   2160

cgaagcccta cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa   2220

atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct   2280

agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat   2340

tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc   2400

tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg   2460

agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa   2520

aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg   2580

ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg   2640

ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa   2700

gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc   2760

acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca   2820

tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga   2880

ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg   2940

aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca   3000

attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt caaagccccc   3060

agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc   3120

acggtcatta ggtaagtgag agtttcctgc ttagtcacag gagcgaatct ggagctcatg   3180

aggctgactc ttctaaaatg cagccacagg tagtcatcga atccggcttc ctatgctgtg   3240

caatcaacaa atcaaaataa cttgtgtcat cattagaatg tcagatgtgc ttctacgaac   3300

taagctgact cttttaattc tttggcaaag ggttggcaaa ctaggactgt ttgccaaatt   3360

caggctgcct cctattttta gagtcttcct gaaacacagc tacacccgta ttatccatgg   3420

ctgctttcct gtcacagtga gtaagtagct gggactgaga aggcatggcc tccaaagtct   3480

aaaatattta ctctctagca ctttgtagaa aaaccttagc taggcacagt ggctaacgcc   3540

tgtaatccca gcattttggg aggccaaggc aggcagatca cctgaggtca ggagttccag   3600

accagcctgg ccaacatggt gaaatcccat ctctacaaaa ataaaacagt tagctgggca   3660

tgatggcggg tgcctgtaat cccagctact cgggaggctg aggcaggata gtcgcttgaa   3720

cccaggaggt ggaggttgca atgagccaag atcatgccac tgcactccag cctggacgac   3780

agagtgagac tccatcacaa gaaaaaaaga actttgtcaa cctctgtctt agggcgcctt   3840

gtcacaggct tcgggtcaga cggattcaac cttgcatcag ccatttgtta gccaggtcac   3900

tctgttcttt gtctgtaaat gagattgatc gttgttccca ctgagagtgt cagctccttc   3960

ccgtagagca ggcatgatga ttgtactcac ctctgacacc attgtgagtg ccacattcct   4020

tcccacgtcc ttgtcactgt aagagatgcc cacctgagca ccaaccccag gttatcttcc   4080

cctttgtctt ccagcccccc agaaacagct acgactcaac ctacccaatc atttcatcat   4140

cagattgcca ctgtctctag ttcaggtctc ttgggactgg cactcagaaa tctcataata   4200

aatcctcttg aggcttctca tacactcgtc ttcttccaat cttctttccc tcaaaatctc   4260

atattttggt tccacttcac ccaccgtcat tctccatatc actcccagga gttaggcaaa   4320

aagccccttc cgttcttccg tatgttaaac ttagaatcac tctgttccct gctctgcgtt   4380

tctatttttt gtttttcctc catttactag tagcttaaca ctttctaaca gtgttcttat   4440

tattgatacg tatctatctc ttccataagc ttataaggtc acggataata cttctcattg   4500

tagtacgtaa atgacgtggg ctagatatga gttgaataaa cagttatacc tgtaaattct   4560

tacagagtga aaataaattg ttatacttta caatttgttt ctctctttag accatttcca   4620

ggacttgtga ttaataaccg tgagtatttt gtgaagtgtt ttgtttttgt tttttcctgg   4680

ggtctgacgt gtgtgcgtgt gagtgtgtat acatgcttaa cgtatatcac gttacttcac   4740

ctatgtcagt aaccaggcca aatacttgtt ttagccctca gtaaaaacac caggcacttc   4800

ctagttgtaa aattattcaa gcttcttaac ttcctatcct cgatgcactt aatcataaaa   4860

tggtaataat agcaccgatt ttgggggagt cgttccagta gatggaaagc atctggaaca   4920

ggtgtcagca agctcctgcc gacgtgtatg cataaagttt tattgaaacc accatcgtgt   4980

ccatttgttt atggcagaac tgagagatgg cagcagcaag tgtgtgcctg caaaacctaa   5040

aatatttact aattggctct gcaagaaaag agtttgcatc cccctaacct agaacagtgt   5100

ctagcctcta gtatgtgttt agcctacagt atgtgctcag cgaatacaat ctatatttat   5160

tactgctttt atgactgtta taattactgt gcttggattt cgttacaaag taagtcacaa   5220

tgtgcctgct tctgttagta tttcagcaca gtgcctggca cacatggggc tctcaaatat   5280

tgctgagcga gtgaacaaat gtcctttcaa ttccttaacg ttgatgtcat tttcaatagt   5340

attttgagcc aaacttaatt ttgcgagtgt gttttgtttt cttaacttta ttattaaaaa   5400

tgtataaaag tgaggccagg cgtggtggct cacgcctgta atcccagcag tttgggaggc   5460

tgaggcaggc ggatcagttg aggttgggag ttggagacca gcccgtccaa catggtgaaa   5520

gcctgtctct actaaaaata caaaaatcag ctgggtgtgg tggcgcgtgc ctgtaatccc   5580

agctactcag gaggctgagg caggagagtt gcttgaatcc tagaggtgga ggttgcagtg   5640

agctgagatc gtgccattgc actccagcct gggcaacaag agcaaaactc tgtcccaata   5700

aataaataaa taaaatgttc tcttttgttc ctgttcttgt gcggtagtgt ggtatagagt   5760

tttatggtaa ttactgtgaa ttagtgattc tgagggacat atcagaactc tgaggtttgt   5820

ttccttctca tcttgaggga aacagcaaat gtatgttaaa atgcttttcc aagggaacaa   5880

cacatcctta cattatttaa accaatctgc ttcattttca gagctggttg atcagagtga   5940

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   6000

agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag accccacgtg   6060

gtagacctct tccctcctag ggtaaatcag cttctgtgtc agggatgctg tgtggtgtcc   6120

atctgaaccc cctgcatacg cgtagctaat gtgatctccc cactttcaca taagatggtg   6180

gccctgcctt cagggaatgt gggagccagg tgggagcctt cccggatatt taagctagaa   6240

gattctacag ggagattctc cttggatcaa tatatgtctc tcagtcaaag atgtaaaagc   6300

acttttgcct taaaaagaat gttctgtttc taaatagagt caacgttgtc ctcctcattg   6360

gaattcacta tgagtcagaa tcattagact gacttttttt tttccatagt aatagtattt   6420

tgcagagtct cacagagctg cagatctttt gttcatcttg cagagttaac aagtctgatc   6480

ctgttagtcc agatttctta aatttggcca agttataata ggagcagtag cttgagaccc   6540

gaagtcagga aactttgaca atggattttt ttttttaatc cagagacttg tactggaatt   6600

tgccttaccc tgtcagctca tggacttaag gtttcatccc gctttatgag tgcttctgaa   6660

tccaagtcat tgttacctga atttgcaaat taagttgtga tattcgtgac tgttaaattc   6720

ctgtaattag attaacctct ttgcttgctt gtttgttttc tctcctattt tagcttaaag   6780

tatcagtggt tgagaagagc ttttcggacc tgttactacc ccaagctgtg taatatactt   6840

gtataacaga aataccttct atacaaacct ttttttctac ttttagatag aaatgtctac   6900

tttttcagca gttctgtgaa ttaaagagca gagtgactgt gggtctggaa tggctggtgt   6960

acttgggaat gtactatcag gattttacag caatgctggg aaatgacagg gaaaatgaca   7020

ggaatgaatc tcaccagatt ttttatgtac tcagcagagc cttgagttac ggtgtttatt   7080

ttccaatcaa gtgaagatat ctcctacttc tcctactgga acatctcagc ttctgcagtg   7140

aagaaaaatt cctgtgatag ttcagttctt tagtttttct atttgaaaaa aaaaaatcat   7200

ttaaatgatc ctttgttcac ggctctcctt aatgactgag tgaacagttc ctatctgtat   7260

atttgactaa accttttcct aagctatctc tcatggttcc tatgtttttt tatcataatt   7320

aaaagcaaaa ccatctggat cacctaacag tcagaggtca gtatctcagc gtgtgaatta   7380

tagaggaaat acagagagaa cctcttccac ttttactttt cgtccaaata aaatgcatgg   7440

tgtaccagaa gttgaagatc gggttgagga ttggggctag ctcgatgaca ctaaggcccc   7500

aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg ctgttctagc cggccccctc   7560

tccaggggtc gccgtggccg gcattatttc ctagttcttc ttgtaaccct gaggtgccag   7620

cgcggggagt gaggaggggt cagggggcta aggatgcaac ctctgacgtt ctgcgccttc   7680

ctaggagagt cttacatgtg ttgagatttc acaagcaatg cgagttgtaa aataccagct   7740

ctacaagaag ctaggctctg tgacggcata gttttcagta gctttatcac aatattcaca   7800

atggagaatt atatgacatg gtagcagaaa taggcccttt tatgtgttgc ttctatttta   7860

cctcaaattg tagatatagg gtaatcaata aaatccatcc atgcctttca cacactaagt   7920


<210>  4835
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  4835

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
            420                 425                 430


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
        435                 440                 445


Phe Asn Leu Lys Phe Ala 
    450


<210>  4836
<211>  4004
<212>  DNA
<213>  Homo sapiens

<400>  4836
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gtcaaagaag attggaatgt   1980

cagaattacc aagctacgga agcaagtgga agagattttt aatttgaaat ttgcttagat   2040

ttgttgacag cggtttcctg gagtgctgtc ttgagaacga ttctgaggag gctcagcaag   2100

aaagagtgtt tcagttgatt gggtgtgtct gtcatggaga aggaactcaa gctcttggac   2160

tcaccgaggc agtaaaagta ccatatcctg tgtttgaatc aaacccggag ttcttgtatg   2220

tggaaggctt gccagagggg attcccttcc gaagccctac ctggtttgga attccacgac   2280

ttgaaaggat cgtccgcggg agtaataaaa tcaagttcgt tgttaaaaaa cctgaactag   2340

ttatttccta cttgcctcct gggatggcta gtaaaataaa cactaaagct ttgcagtccc   2400

ccaaaagacc acgaagtcct gggagtaatt caaaggttcc tgaaattgag gtcaccgtgg   2460

aaggccctaa taacaacaat cctcaaacct cagctgttcg aaccccgacc cagactaacg   2520

gttctaacgt tcccttcaag ccacgaggga gagagttttc ctttgaggcc tggaatgcca   2580

aaatcacgga cctaaaacag aaagttgaaa atctcttcaa tgagaaatgt ggggaagctc   2640

ttggccttaa acaagctgtg aaggtgccgt tcgcgttatt tgagtctttc ccggaagact   2700

tttatgtgga aggcttacct gagggtgtgc cattccgaag accatcgact tttggcattc   2760

cgaggctgga gaagatactc agaaacaaag ccaaaattaa gttcatcatt aaaaagcccg   2820

aaatgtttga gacggcgatt aaggagagca cctcctctaa gagccctccc agaaaaataa   2880

attcatcacc caatgttaat actactgcat caggtgttga agaccttaac atcattcagg   2940

tgacaattcc agatgatgat aatgaaagac tctcgaaagt tgaaaaagct agacagctaa   3000

gagaacaagt gaatgacctc tttagtcgga aatttggtga agctattggt atgggttttc   3060

ctgtgaaagt tccctacagg aaaatcacaa ttaaccctgg ctgtgtggtg gttgatggca   3120

tgcccccggg ggtgtccttc aaagccccca gctacctgga aatcagctcc atgagaagga   3180

tcttagactc tgccgagttt atcaaattca cggtcattag accatttcca ggacttgtga   3240

ttaataacca gctggttgat cagagtgagt cagaaggccc cgtgatacaa gaatcagctg   3300

aaccaagcca gttggaagtt ccagccacag aagaaataaa agagactgat ggaagctctc   3360

agatcaagca agaaccagac cccacgtggt agacctcttc cctcctaggc aaaaccatct   3420

ggatcaccta acagtcagag gtcagtatct cagcgtgtga attatagagg aaatacagag   3480

agaacctctt ccacttttac ttttcgtcca aataaaatgc atggtgtacc agaagttgaa   3540

gatcgggttg aggattgggg ctagctcgat gacactaagg ccccaacatc gcgggacctg   3600

ctgtggcgcg gattcttagg aacgctgttc tagccggccc cctctccagg ggtcgccgtg   3660

gccggcatta tttcctagtt cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag   3720

gggtcagggg gctaaggatg caacctctga cgttctgcgc cttcctagga gagtcttaca   3780

tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc agctctacaa gaagctaggc   3840

tctgtgacgg catagttttc agtagcttta tcacaatatt cacaatggag aattatatga   3900

catggtagca gaaataggcc cttttatgtg ttgcttctat tttacctcaa attgtagata   3960

tagggtaatc aataaaatcc atccatgcct ttcacacact aagt                    4004


<210>  4837
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  4837

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535


<210>  4838
<211>  5156
<212>  DNA
<213>  Homo sapiens

<400>  4838
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2100

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2160

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2220

tgaatcaaac ccggagttct tgaaaggatc gtccgcggga gtaataaaat caagttcgtt   2280

gttaaaaaac ctgaactagt tatttcctac ttgcctcctg ggatggctag taaaataaac   2340

actaaagctt tgcagtcccc caaaagacca cgaagtcctg ggagtaattc aaaggttcct   2400

gaaattgagg tcaccgtgga aggccctaat aacaacaatc ctcaaacctc agctgttcga   2460

accccgaccc agactaacgg ttctaacgtt cccttcaagc cacgagggag agagttttcc   2520

tttgaggcct ggaatgccaa aatcacggac ctaaaacaga aagttgaaaa tctcttcaat   2580

gagaaatgtg gggaagctct tggccttaaa caagctgtga aggtgccgtt cgcgttattt   2640

gagtctttcc cggaagactt ttatgtggaa ggcttacctg agggtgtgcc attccgaaga   2700

ccatcgactt ttggcattcc gaggctggag aagatactca gaaacaaagc caaaattaag   2760

ttcatcatta aaaagcccga aatgtttgag acggcgatta aggagagcac ctcctctaag   2820

agccctccca gaaaaataaa ttcatcaccc aatgttaata ctactgcatc aggtgttgaa   2880

gaccttaaca tcattcaggt gacaattcca gatgatgata atgaaagact ctcgaaagtt   2940

gaaaaagcta gacagctaag agaacaagtg aatgacctct ttagtcggaa atttggtgaa   3000

gctattggta tgggttttcc tgtgaaagtt ccctacagga aaatcacaat taaccctggc   3060

tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca aagcccccag ctacctggaa   3120

atcagctcca tgagaaggat cttagactct gccgagttta tcaaattcac ggtcattaga   3180

ccatttccag gacttgtgat taataaccag ctggttgatc agagtgagtc agaaggcccc   3240

gtgatacaag aatcagctga accaagccag ttggaagttc cagccacaga aggtaaaagg   3300

acctcttccc tcctagggta aatcagcttc tgtgtcaggg atgctgtgtg gtgtccatct   3360

gaaccccctg catacgcgta gctaatgtga tctccccact ttcacataag atggtggccc   3420

tgccttcagg gaatgtggga gccaggtggg agccttcccg gatatttaag ctagaagatt   3480

ctacagggag attctccttg gatcaatata tgtctctcag tcaaagatgt aaaagcactt   3540

ttgccttaaa aagaatgttc tgtttctaaa tagagtcaac gttgtcctcc tcattggaat   3600

tcactatgag tcagaatcat tagactgact tttttttttc catagtaata gtattttgca   3660

gagtctcaca gagctgcaga tcttttgttc atcttgcaga gttaacaagt ctgatcctgt   3720

tagtccagat ttcttaaatt tggccaagtt ataataggag cagtagcttg agacccgaag   3780

tcaggaaact ttgacaatgg attttttttt ttaatccaga gacttgtact ggaatttgcc   3840

ttaccctgtc agctcatgga cttaaggttt catcccgctt tatgagtgct tctgaatcca   3900

agtcattgtt acctgaattt gcaaattaag ttgtgatatt cgtgactgtt aaattcctgt   3960

aattagatta acctctttgc ttgcttgttt gttttctctc ctattttagc ttaaagtatc   4020

agtggttgag aagagctttt cggacctgtt actaccccaa gctgtgtaat atacttgtat   4080

aacagaaata ccttctatac aaaccttttt ttctactttt agatagaaat gtctactttt   4140

tcagcagttc tgtgaattaa agagcagagt gactgtgggt ctggaatggc tggtgtactt   4200

gggaatgtac tatcaggatt ttacagcaat gctgggaaat gacagggaaa atgacaggaa   4260

tgaatctcac cagatttttt atgtactcag cagagccttg agttacggtg tttattttcc   4320

aatcaagtga agatatctcc tacttctcct actggaacat ctcagcttct gcagtgaaga   4380

aaaattcctg tgatagttca gttctttagt ttttctattt gaaaaaaaaa aatcatttaa   4440

atgatccttt gttcacggct ctccttaatg actgagtgaa cagttcctat ctgtatattt   4500

gactaaacct tttcctaagc tatctctcat ggttcctatg tttttttatc ataattaaaa   4560

gcaaaaccat ctggatcacc taacagtcag aggtcagtat ctcagcgtgt gaattataga   4620

ggaaatacag agagaacctc ttccactttt acttttcgtc caaataaaat gcatggtgta   4680

ccagaagttg aagatcgggt tgaggattgg ggctagctcg atgacactaa ggccccaaca   4740

tcgcgggacc tgctgtggcg cggattctta ggaacgctgt tctagccggc cccctctcca   4800

ggggtcgccg tggccggcat tatttcctag ttcttcttgt aaccctgagg tgccagcgcg   4860

gggagtgagg aggggtcagg gggctaagga tgcaacctct gacgttctgc gccttcctag   4920

gagagtctta catgtgttga gatttcacaa gcaatgcgag ttgtaaaata ccagctctac   4980

aagaagctag gctctgtgac ggcatagttt tcagtagctt tatcacaata ttcacaatgg   5040

agaattatat gacatggtag cagaaatagg cccttttatg tgttgcttct attttacctc   5100

aaattgtaga tatagggtaa tcaataaaat ccatccatgc ctttcacaca ctaagt       5156


<210>  4839
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  4839

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys 
        595                 600                 605


Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu 
    610                 615                 620


Asn 
625


<210>  4840
<211>  5059
<212>  DNA
<213>  Homo sapiens

<400>  4840
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040

taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2100

ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2160

ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2220

ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2280

ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2340

atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2400

agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2460

agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2520

tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2580

ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2640

tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2700

ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2760

atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2820

ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2880

tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   2940

ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   3000

tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3060

ttatcaaatt cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg   3120

atcagagtga gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag   3180

ttccagccac agaaggtaaa aggacctctt ccctcctagg gtaaatcagc ttctgtgtca   3240

gggatgctgt gtggtgtcca tctgaacccc ctgcatacgc gtagctaatg tgatctcccc   3300

actttcacat aagatggtgg ccctgccttc agggaatgtg ggagccaggt gggagccttc   3360

ccggatattt aagctagaag attctacagg gagattctcc ttggatcaat atatgtctct   3420

cagtcaaaga tgtaaaagca cttttgcctt aaaaagaatg ttctgtttct aaatagagtc   3480

aacgttgtcc tcctcattgg aattcactat gagtcagaat cattagactg actttttttt   3540

ttccatagta atagtatttt gcagagtctc acagagctgc agatcttttg ttcatcttgc   3600

agagttaaca agtctgatcc tgttagtcca gatttcttaa atttggccaa gttataatag   3660

gagcagtagc ttgagacccg aagtcaggaa actttgacaa tggatttttt tttttaatcc   3720

agagacttgt actggaattt gccttaccct gtcagctcat ggacttaagg tttcatcccg   3780

ctttatgagt gcttctgaat ccaagtcatt gttacctgaa tttgcaaatt aagttgtgat   3840

attcgtgact gttaaattcc tgtaattaga ttaacctctt tgcttgcttg tttgttttct   3900

ctcctatttt agcttaaagt atcagtggtt gagaagagct tttcggacct gttactaccc   3960

caagctgtgt aatatacttg tataacagaa ataccttcta tacaaacctt tttttctact   4020

tttagataga aatgtctact ttttcagcag ttctgtgaat taaagagcag agtgactgtg   4080

ggtctggaat ggctggtgta cttgggaatg tactatcagg attttacagc aatgctggga   4140

aatgacaggg aaaatgacag gaatgaatct caccagattt tttatgtact cagcagagcc   4200

ttgagttacg gtgtttattt tccaatcaag tgaagatatc tcctacttct cctactggaa   4260

catctcagct tctgcagtga agaaaaattc ctgtgatagt tcagttcttt agtttttcta   4320

tttgaaaaaa aaaaatcatt taaatgatcc tttgttcacg gctctcctta atgactgagt   4380

gaacagttcc tatctgtata tttgactaaa ccttttccta agctatctct catggttcct   4440

atgttttttt atcataatta aaagcaaaac catctggatc acctaacagt cagaggtcag   4500

tatctcagcg tgtgaattat agaggaaata cagagagaac ctcttccact tttacttttc   4560

gtccaaataa aatgcatggt gtaccagaag ttgaagatcg ggttgaggat tggggctagc   4620

tcgatgacac taaggcccca acatcgcggg acctgctgtg gcgcggattc ttaggaacgc   4680

tgttctagcc ggccccctct ccaggggtcg ccgtggccgg cattatttcc tagttcttct   4740

tgtaaccctg aggtgccagc gcggggagtg aggaggggtc agggggctaa ggatgcaacc   4800

tctgacgttc tgcgccttcc taggagagtc ttacatgtgt tgagatttca caagcaatgc   4860

gagttgtaaa ataccagctc tacaagaagc taggctctgt gacggcatag ttttcagtag   4920

ctttatcaca atattcacaa tggagaatta tatgacatgg tagcagaaat aggccctttt   4980

atgtgttgct tctattttac ctcaaattgt agatataggg taatcaataa aatccatcca   5040

tgcctttcac acactaagt                                                5059


<210>  4841
<211>  879
<212>  PRT
<213>  Homo sapiens

<400>  4841

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
    450                 455                 460


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
465                 470                 475                 480


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
                485                 490                 495


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
            500                 505                 510


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
        515                 520                 525


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
    530                 535                 540


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
545                 550                 555                 560


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
                565                 570                 575


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
            580                 585                 590


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
        595                 600                 605


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
    610                 615                 620


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
625                 630                 635                 640


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
                645                 650                 655


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
            660                 665                 670


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
        675                 680                 685


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
    690                 695                 700


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
705                 710                 715                 720


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
                725                 730                 735


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
            740                 745                 750


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
        755                 760                 765


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
    770                 775                 780


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
785                 790                 795                 800


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
                805                 810                 815


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
            820                 825                 830


Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser 
        835                 840                 845


Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu 
    850                 855                 860


Glu Val Pro Ala Thr Glu Gly Lys Arg Thr Ser Ser Leu Leu Gly 
865                 870                 875


<210>  4842
<211>  7109
<212>  DNA
<213>  Homo sapiens

<400>  4842
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1980

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   2040

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   2100

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2160

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2220

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2280

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2340

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2400

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2460

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2520

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2580

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2640

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2700

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2760

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2820

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2880

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2940

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   3000

cacggtcatt aggtaagtga gagtttcctg cttagtcaca ggagcgaatc tggagctcat   3060

gaggctgact cttctaaaat gcagccacag gtagtcatcg aatccggctt cctatgctgt   3120

gcaatcaaca aatcaaaata acttgtgtca tcattagaat gtcagatgtg cttctacgaa   3180

ctaagctgac tcttttaatt ctttggcaaa gggttggcaa actaggactg tttgccaaat   3240

tcaggctgcc tcctattttt agagtcttcc tgaaacacag ctacacccgt attatccatg   3300

gctgctttcc tgtcacagtg agtaagtagc tgggactgag aaggcatggc ctccaaagtc   3360

taaaatattt actctctagc actttgtaga aaaaccttag ctaggcacag tggctaacgc   3420

ctgtaatccc agcattttgg gaggccaagg caggcagatc acctgaggtc aggagttcca   3480

gaccagcctg gccaacatgg tgaaatccca tctctacaaa aataaaacag ttagctgggc   3540

atgatggcgg gtgcctgtaa tcccagctac tcgggaggct gaggcaggat agtcgcttga   3600

acccaggagg tggaggttgc aatgagccaa gatcatgcca ctgcactcca gcctggacga   3660

cagagtgaga ctccatcaca agaaaaaaag aactttgtca acctctgtct tagggcgcct   3720

tgtcacaggc ttcgggtcag acggattcaa ccttgcatca gccatttgtt agccaggtca   3780

ctctgttctt tgtctgtaaa tgagattgat cgttgttccc actgagagtg tcagctcctt   3840

cccgtagagc aggcatgatg attgtactca cctctgacac cattgtgagt gccacattcc   3900

ttcccacgtc cttgtcactg taagagatgc ccacctgagc accaacccca ggttatcttc   3960

ccctttgtct tccagccccc cagaaacagc tacgactcaa cctacccaat catttcatca   4020

tcagattgcc actgtctcta gttcaggtct cttgggactg gcactcagaa atctcataat   4080

aaatcctctt gaggcttctc atacactcgt cttcttccaa tcttctttcc ctcaaaatct   4140

catattttgg ttccacttca cccaccgtca ttctccatat cactcccagg agttaggcaa   4200

aaagcccctt ccgttcttcc gtatgttaaa cttagaatca ctctgttccc tgctctgcgt   4260

ttctattttt tgtttttcct ccatttacta gtagcttaac actttctaac agtgttctta   4320

ttattgatac gtatctatct cttccataag cttataaggt cacggataat acttctcatt   4380

gtagtacgta aatgacgtgg gctagatatg agttgaataa acagttatac ctgtaaattc   4440

ttacagagtg aaaataaatt gttatacttt acaatttgtt tctctcttta gaccatttcc   4500

aggacttgtg attaataacc gtgagtattt tgtgaagtgt tttgtttttg ttttttcctg   4560

gggtctgacg tgtgtgcgtg tgagtgtgta tacatgctta acgtatatca cgttacttca   4620

cctatgtcag taaccaggcc aaatacttgt tttagccctc agtaaaaaca ccaggcactt   4680

cctagttgta aaattattca agcttcttaa cttcctatcc tcgatgcact taatcataaa   4740

atggtaataa tagcaccgat tttgggggag tcgttccagt agatggaaag catctggaac   4800

aggtgtcagc aagctcctgc cgacgtgtat gcataaagtt ttattgaaac caccatcgtg   4860

tccatttgtt tatggcagaa ctgagagatg gcagcagcaa gtgtgtgcct gcaaaaccta   4920

aaatatttac taattggctc tgcaagaaaa gagtttgcat ccccctaacc tagaacagtg   4980

tctagcctct agtatgtgtt tagcctacag tatgtgctca gcgaatacaa tctatattta   5040

ttactgcttt tatgactgtt ataattactg tgcttggatt tcgttacaaa gtaagtcaca   5100

atgtgcctgc ttctgttagt atttcagcac agtgcctggc acacatgggg ctctcaaata   5160

ttgctgagcg agtgaacaaa tgtcctttca attccttaac gttgatgtca ttttcaatag   5220

tattttgagc caaacttaat tttgcgagtg tgttttgttt tcttaacttt attattaaaa   5280

atgtataaaa gtgaggccag gcgtggtggc tcacgcctgt aatcccagca gtttgggagg   5340

ctgaggcagg cggatcagtt gaggttggga gttggagacc agcccgtcca acatggtgaa   5400

agcctgtctc tactaaaaat acaaaaatca gctgggtgtg gtggcgcgtg cctgtaatcc   5460

cagctactca ggaggctgag gcaggagagt tgcttgaatc ctagaggtgg aggttgcagt   5520

gagctgagat cgtgccattg cactccagcc tgggcaacaa gagcaaaact ctgtcccaat   5580

aaataaataa ataaaatgtt ctcttttgtt cctgttcttg tgcggtagtg tggtatagag   5640

ttttatggta attactgtga attagtgatt ctgagggaca tatcagaact ctgaggtttg   5700

tttccttctc atcttgaggg aaacagcaaa tgtatgttaa aatgcttttc caagggaaca   5760

acacatcctt acattattta aaccaatctg cttcattttc agagctggtt gatcagagtg   5820

agtcagaagg ccccgtgata caagaatcag ctgaaccaag ccagttggaa gttccagcca   5880

cagaagaaat aaaagagact gatggaagct ctcagatcaa gcaagaacca gaccccacgt   5940

ggtagacctc ttccctccta ggcttaaagt atcagtggtt gagaagagct tttcggacct   6000

gttactaccc caagctgtgt aatatacttg tataacagaa ataccttcta tacaaacctt   6060

tttttctact tttagataga aatgtctact ttttcagcag ttctgtgaat taaagagcag   6120

agtgactgtg ggtctggaat ggctggtgta cttgggaatg tactatcagg attttacagc   6180

aatgctggga aatgacaggg aaaatgacag gaatgaatct caccagattt tttatgtact   6240

cagcagagcc ttgagttacg gtgtttattt tccaatcaag tgaagatatc tcctacttct   6300

cctactggaa catctcagct tctgcagtga agaaaaattc ctgtgatagt tcagttcttt   6360

agtttttcta tttgaaaaaa aaaaatcatt taaatgatcc tttgttcacg gctctcctta   6420

atgactgagt gaacagttcc tatctgtata tttgactaaa ccttttccta agctatctct   6480

catggttcct atgttttttt atcataatta aaagcaaaac catctggatc acctaacagt   6540

cagaggtcag tatctcagcg tgtgaattat agaggaaata cagagagaac ctcttccact   6600

tttacttttc gtccaaataa aatgcatggt gtaccagaag ttgaagatcg ggttgaggat   6660

tggggctagc tcgatgacac taaggcccca acatcgcggg acctgctgtg gcgcggattc   6720

ttaggaacgc tgttctagcc ggccccctct ccaggggtcg ccgtggccgg cattatttcc   6780

tagttcttct tgtaaccctg aggtgccagc gcggggagtg aggaggggtc agggggctaa   6840

ggatgcaacc tctgacgttc tgcgccttcc taggagagtc ttacatgtgt tgagatttca   6900

caagcaatgc gagttgtaaa ataccagctc tacaagaagc taggctctgt gacggcatag   6960

ttttcagtag ctttatcaca atattcacaa tggagaatta tatgacatgg tagcagaaat   7020

aggccctttt atgtgttgct tctattttac ctcaaattgt agatataggg taatcaataa   7080

aatccatcca tgcctttcac acactaagt                                     7109


<210>  4843
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  4843

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
    450                 455                 460


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
465                 470                 475                 480


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
                485                 490                 495


Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys 
            500                 505                 510


Asn Leu Asn 
        515


<210>  4844
<211>  3731
<212>  DNA
<213>  Homo sapiens

<400>  4844
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agctcaagct cttggactca ccgaggcagt aaaagtacca tatcctgtgt   1920

ttgaatcaaa cccggagttc ttgtatgtgg aaggcttgcc agaggggatt cccttccgaa   1980

gccctacctg gtttggaatt ccacgacttg aaaggatcgt ccgcgggagt aataaaatca   2040

agttcgttgt taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta   2100

aaataaacac taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa   2160

aggttcctga aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag   2220

ctgttcgaac cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag   2280

agttttcctt tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc   2340

tcttcaatga gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg   2400

cgttatttga gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat   2460

tccgaagacc atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca   2520

aaattaagtt catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct   2580

cctctaagag ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag   2640

gtgttgaaga ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct   2700

cgaaagttga aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat   2760

ttggtgaagc tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta   2820

accctggctg tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct   2880

acctggaaat cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg   2940

tcattagacc atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag   3000

aaggccccgt gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag   3060

aaataaaaga gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga   3120

cctcttccct cctaggcaaa accatctgga tcacctaaca gtcagaggtc agtatctcag   3180

cgtgtgaatt atagaggaaa tacagagaga acctcttcca cttttacttt tcgtccaaat   3240

aaaatgcatg gtgtaccaga agttgaagat cgggttgagg attggggcta gctcgatgac   3300

actaaggccc caacatcgcg ggacctgctg tggcgcggat tcttaggaac gctgttctag   3360

ccggccccct ctccaggggt cgccgtggcc ggcattattt cctagttctt cttgtaaccc   3420

tgaggtgcca gcgcggggag tgaggagggg tcagggggct aaggatgcaa cctctgacgt   3480

tctgcgcctt cctaggagag tcttacatgt gttgagattt cacaagcaat gcgagttgta   3540

aaataccagc tctacaagaa gctaggctct gtgacggcat agttttcagt agctttatca   3600

caatattcac aatggagaat tatatgacat ggtagcagaa ataggccctt ttatgtgttg   3660

cttctatttt acctcaaatt gtagatatag ggtaatcaat aaaatccatc catgcctttc   3720

acacactaag t                                                        3731


<210>  4845
<211>  844
<212>  PRT
<213>  Homo sapiens

<400>  4845

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala 
            420                 425                 430


Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser 
        435                 440                 445


Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
    450                 455                 460


Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg 
465                 470                 475                 480


Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile 
                485                 490                 495


Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu 
            500                 505                 510


Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro 
        515                 520                 525


Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr 
    530                 535                 540


Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe 
545                 550                 555                 560


Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile 
                565                 570                 575


Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly 
            580                 585                 590


Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe 
        595                 600                 605


Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val 
    610                 615                 620


Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile 
625                 630                 635                 640


Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met 
                645                 650                 655


Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg 
            660                 665                 670


Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu 
        675                 680                 685


Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg 
    690                 695                 700


Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp 
705                 710                 715                 720


Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val 
                725                 730                 735


Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val 
            740                 745                 750


Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu 
        755                 760                 765


Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe 
    770                 775                 780


Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val 
785                 790                 795                 800


Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro 
                805                 810                 815


Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly 
            820                 825                 830


Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
        835                 840


<210>  4846
<211>  4112
<212>  DNA
<213>  Homo sapiens

<400>  4846
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1860

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1920

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1980

aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc   2040

ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt   2100

tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa   2160

taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg   2220

ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg   2280

ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga gggagagagt   2340

tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct   2400

tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt   2460

tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc   2520

gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa   2580

ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct   2640

ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg   2700

ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga   2760

aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg   2820

gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc   2880

ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc   2940

tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca   3000

ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt gagtcagaag   3060

gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc acagaagaaa   3120

taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg tggtagacct   3180

cttccctcct aggcttaaag tatcagtggt tgagaagagc ttttcggacc tgttactacc   3240

ccaagctgta gccttgagtt acggtgttta ttttccaatc aagtgaagat atctcctact   3300

tctcctactg gaacatctca gcttctgcag tgaagaaaaa ttcctgtgat agttcagttc   3360

tttagttttt ctatttgaaa aaaaaaaatc atttaaatga tcctttgttc acggctctcc   3420

ttaatgactg agtgaacagt tcctatctgt atatttgact aaaccttttc ctaagctatc   3480

tctcatggtt cctatgtttt tttatcataa ttaaaagcaa aaccatctgg atcacctaac   3540

agtcagaggt cagtatctca gcgtgtgaat tatagaggaa atacagagag aacctcttcc   3600

acttttactt ttcgtccaaa taaaatgcat ggtgtaccag aagttgaaga tcgggttgag   3660

gattggggct agctcgatga cactaaggcc ccaacatcgc gggacctgct gtggcgcgga   3720

ttcttaggaa cgctgttcta gccggccccc tctccagggg tcgccgtggc cggcattatt   3780

tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc   3840

taaggatgca acctctgacg ttctgcgcct tcctaggaga gtcttacatg tgttgagatt   3900

tcacaagcaa tgcgagttgt aaaataccag ctctacaaga agctaggctc tgtgacggca   3960

tagttttcag tagctttatc acaatattca caatggagaa ttatatgaca tggtagcaga   4020

aataggccct tttatgtgtt gcttctattt tacctcaaat tgtagatata gggtaatcaa   4080

taaaatccat ccatgccttt cacacactaa gt                                 4112


<210>  4847
<211>  863
<212>  PRT
<213>  Homo sapiens

<400>  4847

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg 
            420                 425                 430


Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe 
        435                 440                 445


Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val 
    450                 455                 460


Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly 
465                 470                 475                 480


Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg 
                485                 490                 495


Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu 
            500                 505                 510


Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr 
        515                 520                 525


Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser 
    530                 535                 540


Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn 
545                 550                 555                 560


Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn 
                565                 570                 575


Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn 
            580                 585                 590


Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu 
        595                 600                 605


Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe 
    610                 615                 620


Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro 
625                 630                 635                 640


Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu 
                645                 650                 655


Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys 
            660                 665                 670


Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser 
        675                 680                 685


Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser 
    690                 695                 700


Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp 
705                 710                 715                 720


Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln 
                725                 730                 735


Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly 
            740                 745                 750


Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys 
        755                 760                 765


Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser 
    770                 775                 780


Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe 
785                 790                 795                 800


Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn 
                805                 810                 815


Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser 
            820                 825                 830


Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu 
        835                 840                 845


Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
    850                 855                 860


<210>  4848
<211>  4064
<212>  DNA
<213>  Homo sapiens

<400>  4848
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1980

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   2040

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   2100

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2160

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2220

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2280

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2340

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2400

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2460

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2520

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2580

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2640

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2700

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2760

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2820

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2880

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2940

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   3000

cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg atcagagtga   3060

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   3120

agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag accccacgtg   3180

gtagacctct tccctcctag gagccttgag ttacggtgtt tattttccaa tcaagtgaag   3240

atatctccta cttctcctac tggaacatct cagcttctgc agtgaagaaa aattcctgtg   3300

atagttcagt tctttagttt ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt   3360

tcacggctct ccttaatgac tgagtgaaca gttcctatct gtatatttga ctaaaccttt   3420

tcctaagcta tctctcatgg ttcctatgtt tttttatcat aattaaaagc aaaaccatct   3480

ggatcaccta acagtcagag gtcagtatct cagcgtgtga attatagagg aaatacagag   3540

agaacctctt ccacttttac ttttcgtcca aataaaatgc atggtgtacc agaagttgaa   3600

gatcgggttg aggattgggg ctagctcgat gacactaagg ccccaacatc gcgggacctg   3660

ctgtggcgcg gattcttagg aacgctgttc tagccggccc cctctccagg ggtcgccgtg   3720

gccggcatta tttcctagtt cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag   3780

gggtcagggg gctaaggatg caacctctga cgttctgcgc cttcctagga gagtcttaca   3840

tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc agctctacaa gaagctaggc   3900

tctgtgacgg catagttttc agtagcttta tcacaatatt cacaatggag aattatatga   3960

catggtagca gaaataggcc cttttatgtg ttgcttctat tttacctcaa attgtagata   4020

tagggtaatc aataaaatcc atccatgcct ttcacacact aagt                    4064


<210>  4849
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  4849

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
    450                 455                 460


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
465                 470                 475                 480


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
                485                 490                 495


Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys 
            500                 505                 510


Asn Leu Asn 
        515


<210>  4850
<211>  4171
<212>  DNA
<213>  Homo sapiens

<400>  4850
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2040

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2100

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2160

tgaatcaaac ccggagttct tgaaaggatc gtccgcggga gtaataaaat caagttcgtt   2220

gttaaaaaac ctgaactagt tatttcctac ttgcctcctg ggatggctag taaaataaac   2280

actaaagctt tgcagtcccc caaaagacca cgaagtcctg ggagtaattc aaaggttcct   2340

gaaattgagg tcaccgtgga aggccctaat aacaacaatc ctcaaacctc agctgttcga   2400

accccgaccc agactaacgg ttctaacgtt cccttcaagc cacgagggag agagttttcc   2460

tttgaggcct ggaatgccaa aatcacggac ctaaaacaga aagttgaaaa tctcttcaat   2520

gagaaatgtg gggaagctct tggccttaaa caagctgtga aggtgccgtt cgcgttattt   2580

gagtctttcc cggaagactt ttatgtggaa ggcttacctg agggtgtgcc attccgaaga   2640

ccatcgactt ttggcattcc gaggctggag aagatactca gaaacaaagc caaaattaag   2700

ttcatcatta aaaagcccga aatgtttgag acggcgatta aggagagcac ctcctctaag   2760

agccctccca gaaaaataaa ttcatcaccc aatgttaata ctactgcatc aggtgttgaa   2820

gaccttaaca tcattcaggt gacaattcca gatgatgata atgaaagact ctcgaaagtt   2880

gaaaaagcta gacagctaag agaacaagtg aatgacctct ttagtcggaa atttggtgaa   2940

gctattggta tgggttttcc tgtgaaagtt ccctacagga aaatcacaat taaccctggc   3000

tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca aagcccccag ctacctggaa   3060

atcagctcca tgagaaggat cttagactct gccgagttta tcaaattcac ggtcattaga   3120

ccatttccag gacttgtgat taataaccag ctggttgatc agagtgagtc agaaggcccc   3180

gtgatacaag aatcagctga accaagccag ttggaagttc cagccacaga agaaataaaa   3240

gagactgatg gaagctctca gatcaagcaa gaaccagacc ccacgtggta gacctcttcc   3300

ctcctaggag ccttgagtta cggtgtttat tttccaatca agtgaagata tctcctactt   3360

ctcctactgg aacatctcag cttctgcagt gaagaaaaat tcctgtgata gttcagttct   3420

ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat cctttgttca cggctctcct   3480

taatgactga gtgaacagtt cctatctgta tatttgacta aaccttttcc taagctatct   3540

ctcatggttc ctatgttttt ttatcataat taaaagcaaa accatctgga tcacctaaca   3600

gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa tacagagaga acctcttcca   3660

cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga agttgaagat cgggttgagg   3720

attggggcta gctcgatgac actaaggccc caacatcgcg ggacctgctg tggcgcggat   3780

tcttaggaac gctgttctag ccggccccct ctccaggggt cgccgtggcc ggcattattt   3840

cctagttctt cttgtaaccc tgaggtgcca gcgcggggag tgaggagggg tcagggggct   3900

aaggatgcaa cctctgacgt tctgcgcctt cctaggagag tcttacatgt gttgagattt   3960

cacaagcaat gcgagttgta aaataccagc tctacaagaa gctaggctct gtgacggcat   4020

agttttcagt agctttatca caatattcac aatggagaat tatatgacat ggtagcagaa   4080

ataggccctt ttatgtgttg cttctatttt acctcaaatt gtagatatag ggtaatcaat   4140

aaaatccatc catgcctttc acacactaag t                                  4171


<210>  4851
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  4851

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala 
            580                 585                 590


Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600                 605


<210>  4852
<211>  4103
<212>  DNA
<213>  Homo sapiens

<400>  4852
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagctca   1980

agctcttgga ctcaccgagg cagtaaaagt accatatcct gtgtttgaat caaacccgga   2040

gttcttgtat gtggaaggct tgccagaggg gattcccttc cgaagcccta cctggtttgg   2100

aattccacga cttgaaagga tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa   2160

acctgaacta gttatttcct acttgcctcc tgggatggct agtaaaataa acactaaagc   2220

tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga   2280

ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc tcagctgttc gaaccccgac   2340

ccagactaac ggttctaacg ttcccttcaa gccacgaggg agagagtttt cctttgaggc   2400

ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa aatctcttca atgagaaatg   2460

tggggaagct cttggcctta aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt   2520

cccggaagac ttttatgtgg aaggcttacc tgagggtgtg ccattccgaa gaccatcgac   2580

ttttggcatt ccgaggctgg agaagatact cagaaacaaa gccaaaatta agttcatcat   2640

taaaaagccc gaaatgtttg agacggcgat taaggagagc acctcctcta agagccctcc   2700

cagaaaaata aattcatcac ccaatgttaa tactactgca tcaggtgttg aagaccttaa   2760

catcattcag gtgacaattc cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc   2820

tagacagcta agagaacaag tgaatgacct ctttagtcgg aaatttggtg aagctattgg   2880

tatgggtttt cctgtgaaag ttccctacag gaaaatcaca attaaccctg gctgtgtggt   2940

ggttgatggc atgcccccgg gggtgtcctt caaagccccc agctacctgg aaatcagctc   3000

catgagaagg atcttagact ctgccgagtt tatcaaattc acggtcatta gaccatttcc   3060

aggacttgtg attaataacc agctggttga tcagagtgag tcagaaggcc ccgtgataca   3120

agaatcagct gaaccaagcc agttggaagt tccagccaca gaagaaataa aagagactga   3180

tggaagctct cagatcaagc aagaaccaga ccccacgtgg tagacctctt ccctcctagg   3240

agccttgagt tacggtgttt attttccaat caagtgaaga tatctcctac ttctcctact   3300

ggaacatctc agcttctgca gtgaagaaaa attcctgtga tagttcagtt ctttagtttt   3360

tctatttgaa aaaaaaaaat catttaaatg atcctttgtt cacggctctc cttaatgact   3420

gagtgaacag ttcctatctg tatatttgac taaacctttt cctaagctat ctctcatggt   3480

tcctatgttt ttttatcata attaaaagca aaaccatctg gatcacctaa cagtcagagg   3540

tcagtatctc agcgtgtgaa ttatagagga aatacagaga gaacctcttc cacttttact   3600

tttcgtccaa ataaaatgca tggtgtacca gaagttgaag atcgggttga ggattggggc   3660

tagctcgatg acactaaggc cccaacatcg cgggacctgc tgtggcgcgg attcttagga   3720

acgctgttct agccggcccc ctctccaggg gtcgccgtgg ccggcattat ttcctagttc   3780

ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc   3840

aacctctgac gttctgcgcc ttcctaggag agtcttacat gtgttgagat ttcacaagca   3900

atgcgagttg taaaatacca gctctacaag aagctaggct ctgtgacggc atagttttca   3960

gtagctttat cacaatattc acaatggaga attatatgac atggtagcag aaataggccc   4020

ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat agggtaatca ataaaatcca   4080

tccatgcctt tcacacacta agt                                           4103


<210>  4853
<211>  933
<212>  PRT
<213>  Homo sapiens

<400>  4853

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
        515                 520                 525


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
    530                 535                 540


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
545                 550                 555                 560


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
                565                 570                 575


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
            580                 585                 590


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
        595                 600                 605


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
    610                 615                 620


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
625                 630                 635                 640


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
                645                 650                 655


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
            660                 665                 670


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
        675                 680                 685


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
    690                 695                 700


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
705                 710                 715                 720


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
                725                 730                 735


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
            740                 745                 750


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
        755                 760                 765


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
    770                 775                 780


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
785                 790                 795                 800


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
                805                 810                 815


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
            820                 825                 830


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
        835                 840                 845


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
    850                 855                 860


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro 
865                 870                 875                 880


Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly 
                885                 890                 895


Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala 
            900                 905                 910


Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu 
        915                 920                 925


Pro Asp Pro Thr Trp 
    930


<210>  4854
<211>  4235
<212>  DNA
<213>  Homo sapiens

<400>  4854
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   2040

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2100

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2160

atcaaacccg gagttcttgt atgtggaagg cttgccagag gggattccct tccgaagccc   2220

tacctggttt ggaattccac gacttgaaag gatcgtccgc gggagtaata aaatcaagtt   2280

cgttgttaaa aaacctgaac tagttatttc ctacttgcct cctgggatgg ctagtaaaat   2340

aaacactaaa gctttgcagt cccccaaaag accacgaagt cctgggagta attcaaaggt   2400

tcctgaaatt gaggtcaccg tggaaggccc taataacaac aatcctcaaa cctcagctgt   2460

tcgaaccccg acccagacta acggttctaa cgttcccttc aagccacgag ggagagagtt   2520

ttcctttgag gcctggaatg ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt   2580

caatgagaaa tgtggggaag ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt   2640

atttgagtct ttcccggaag acttttatgt ggaaggctta cctgagggtg tgccattccg   2700

aagaccatcg acttttggca ttccgaggct ggagaagata ctcagaaaca aagccaaaat   2760

taagttcatc attaaaaagc ccgaaatgtt tgagacggcg attaaggaga gcacctcctc   2820

taagagccct cccagaaaaa taaattcatc acccaatgtt aatactactg catcaggtgt   2880

tgaagacctt aacatcattc aggtgacaat tccagatgat gataatgaaa gactctcgaa   2940

agttgaaaaa gctagacagc taagagaaca agtgaatgac ctctttagtc ggaaatttgg   3000

tgaagctatt ggtatgggtt ttcctgtgaa agttccctac aggaaaatca caattaaccc   3060

tggctgtgtg gtggttgatg gcatgccccc gggggtgtcc ttcaaagccc ccagctacct   3120

ggaaatcagc tccatgagaa ggatcttaga ctctgccgag tttatcaaat tcacggtcat   3180

tagaccattt ccaggacttg tgattaataa ccagctggtt gatcagagtg agtcagaagg   3240

ccccgtgata caagaatcag ctgaaccaag ccagttggaa gttccagcca cagaagaaat   3300

aaaagagact gatggaagct ctcagatcaa gcaagaacca gaccccacgt ggtagacctc   3360

ttccctccta ggagccttga gttacggtgt ttattttcca atcaagtgaa gatatctcct   3420

acttctccta ctggaacatc tcagcttctg cagtgaagaa aaattcctgt gatagttcag   3480

ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa tgatcctttg ttcacggctc   3540

tccttaatga ctgagtgaac agttcctatc tgtatatttg actaaacctt ttcctaagct   3600

atctctcatg gttcctatgt ttttttatca taattaaaag caaaaccatc tggatcacct   3660

aacagtcaga ggtcagtatc tcagcgtgtg aattatagag gaaatacaga gagaacctct   3720

tccactttta cttttcgtcc aaataaaatg catggtgtac cagaagttga agatcgggtt   3780

gaggattggg gctagctcga tgacactaag gccccaacat cgcgggacct gctgtggcgc   3840

ggattcttag gaacgctgtt ctagccggcc ccctctccag gggtcgccgt ggccggcatt   3900

atttcctagt tcttcttgta accctgaggt gccagcgcgg ggagtgagga ggggtcaggg   3960

ggctaaggat gcaacctctg acgttctgcg ccttcctagg agagtcttac atgtgttgag   4020

atttcacaag caatgcgagt tgtaaaatac cagctctaca agaagctagg ctctgtgacg   4080

gcatagtttt cagtagcttt atcacaatat tcacaatgga gaattatatg acatggtagc   4140

agaaataggc ccttttatgt gttgcttcta ttttacctca aattgtagat atagggtaat   4200

caataaaatc catccatgcc tttcacacac taagt                              4235


<210>  4855
<211>  977
<212>  PRT
<213>  Homo sapiens

<400>  4855

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
                565                 570                 575


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
            580                 585                 590


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
        595                 600                 605


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
    610                 615                 620


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
625                 630                 635                 640


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
                645                 650                 655


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
            660                 665                 670


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
        675                 680                 685


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
    690                 695                 700


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
705                 710                 715                 720


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
                725                 730                 735


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
            740                 745                 750


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
        755                 760                 765


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
    770                 775                 780


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
785                 790                 795                 800


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
                805                 810                 815


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
            820                 825                 830


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
        835                 840                 845


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
    850                 855                 860


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
865                 870                 875                 880


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
                885                 890                 895


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
            900                 905                 910


Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile 
        915                 920                 925


Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln 
    930                 935                 940


Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile 
945                 950                 955                 960


Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr 
                965                 970                 975


Trp 



<210>  4856
<211>  4444
<212>  DNA
<213>  Homo sapiens

<400>  4856
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gtcaaagaag attggaatgt   1980

cagaattacc aagctacgga agcaagtgga agagattttt aatttgaaat ttgctcaagc   2040

tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt   2100

cttgtatgtg gaaggcttgc cagaggggat tcccttccga agccctacct ggtttggaat   2160

tccacgactt gaaaggatcg tccgcgggag taataaaatc aagttcgttg ttaaaaaacc   2220

tgaactagtt atttcctact tgcctcctgg gatggctagt aaaataaaca ctaaagcttt   2280

gcagtccccc aaaagaccac gaagtcctgg gagtaattca aaggttcctg aaattgaggt   2340

caccgtggaa ggccctaata acaacaatcc tcaaacctca gctgttcgaa ccccgaccca   2400

gactaacggt tctaacgttc ccttcaagcc acgagggaga gagttttcct ttgaggcctg   2460

gaatgccaaa atcacggacc taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg   2520

ggaagctctt ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg agtctttccc   2580

ggaagacttt tatgtggaag gcttacctga gggtgtgcca ttccgaagac catcgacttt   2640

tggcattccg aggctggaga agatactcag aaacaaagcc aaaattaagt tcatcattaa   2700

aaagcccgaa atgtttgaga cggcgattaa ggagagcacc tcctctaaga gccctcccag   2760

aaaaataaat tcatcaccca atgttaatac tactgcatca ggtgttgaag accttaacat   2820

cattcaggtg acaattccag atgatgataa tgaaagactc tcgaaagttg aaaaagctag   2880

acagctaaga gaacaagtga atgacctctt tagtcggaaa tttggtgaag ctattggtat   2940

gggttttcct gtgaaagttc cctacaggaa aatcacaatt aaccctggct gtgtggtggt   3000

tgatggcatg cccccggggg tgtccttcaa agcccccagc tacctggaaa tcagctccat   3060

gagaaggatc ttagactctg ccgagtttat caaattcacg gtcattagac catttccagg   3120

acttgtgatt aataaccagc tggttgatca gagtgagtca gaaggccccg tgatacaaga   3180

atcagctgaa ccaagccagt tggaagttcc agccacagaa gaaataaaag agactgatgg   3240

aagctctcag atcaagcaag aaccagaccc cacgtggtag acctcttccc tcctaggctt   3300

aaagtatcag tggttgagaa gagcttttcg gacctgttac taccccaagc tgtgtaatat   3360

acttgtataa cagaaatacc ttctatacaa accttttttt ctacttttag atagaaatgt   3420

ctactttttc agcagttctg tgaattaaag agcagagtga ctgtgggtct ggaatggctg   3480

gtgtacttgg gaatgtacta tcaggatttt acagcaatgc tgggaaatga cagggaaaat   3540

gacaggaatg aatctcacca gattttttat gtactcagca gagccttgag ttacggtgtt   3600

tattttccaa tcaagtgaag atatctccta cttctcctac tggaacatct cagcttctgc   3660

agtgaagaaa aattcctgtg atagttcagt tctttagttt ttctatttga aaaaaaaaaa   3720

tcatttaaat gatcctttgt tcacggctct ccttaatgac tgagtgaaca gttcctatct   3780

gtatatttga ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt tttttatcat   3840

aattaaaagc aaaaccatct ggatcaccta acagtcagag gtcagtatct cagcgtgtga   3900

attatagagg aaatacagag agaacctctt ccacttttac ttttcgtcca aataaaatgc   3960

atggtgtacc agaagttgaa gatcgggttg aggattgggg ctagctcgat gacactaagg   4020

ccccaacatc gcgggacctg ctgtggcgcg gattcttagg aacgctgttc tagccggccc   4080

cctctccagg ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa ccctgaggtg   4140

ccagcgcggg gagtgaggag gggtcagggg gctaaggatg caacctctga cgttctgcgc   4200

cttcctagga gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc   4260

agctctacaa gaagctaggc tctgtgacgg catagttttc agtagcttta tcacaatatt   4320

cacaatggag aattatatga catggtagca gaaataggcc cttttatgtg ttgcttctat   4380

tttacctcaa attgtagata tagggtaatc aataaaatcc atccatgcct ttcacacact   4440

aagt                                                                4444


<210>  4857
<211>  952
<212>  PRT
<213>  Homo sapiens

<400>  4857

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr 
                565                 570                 575


Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys 
            580                 585                 590


Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro 
        595                 600                 605


Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys 
    610                 615                 620


Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val 
625                 630                 635                 640


Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg 
                645                 650                 655


Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly 
            660                 665                 670


Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys 
        675                 680                 685


Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly 
    690                 695                 700


Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro 
705                 710                 715                 720


Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg 
                725                 730                 735


Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys 
            740                 745                 750


Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala 
        755                 760                 765


Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser 
    770                 775                 780


Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile 
785                 790                 795                 800


Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val 
                805                 810                 815


Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg 
            820                 825                 830


Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr 
        835                 840                 845


Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro 
    850                 855                 860


Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met 
865                 870                 875                 880


Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
                885                 890                 895


Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu 
            900                 905                 910


Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu 
        915                 920                 925


Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile 
    930                 935                 940


Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  4858
<211>  7801
<212>  DNA
<213>  Homo sapiens

<400>  4858
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1980

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   2040

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   2100

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2160

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2220

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2280

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2340

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2400

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2460

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2520

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2580

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2640

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2700

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2760

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2820

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2880

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2940

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   3000

cacggtcatt aggtaagtga gagtttcctg cttagtcaca ggagcgaatc tggagctcat   3060

gaggctgact cttctaaaat gcagccacag gtagtcatcg aatccggctt cctatgctgt   3120

gcaatcaaca aatcaaaata acttgtgtca tcattagaat gtcagatgtg cttctacgaa   3180

ctaagctgac tcttttaatt ctttggcaaa gggttggcaa actaggactg tttgccaaat   3240

tcaggctgcc tcctattttt agagtcttcc tgaaacacag ctacacccgt attatccatg   3300

gctgctttcc tgtcacagtg agtaagtagc tgggactgag aaggcatggc ctccaaagtc   3360

taaaatattt actctctagc actttgtaga aaaaccttag ctaggcacag tggctaacgc   3420

ctgtaatccc agcattttgg gaggccaagg caggcagatc acctgaggtc aggagttcca   3480

gaccagcctg gccaacatgg tgaaatccca tctctacaaa aataaaacag ttagctgggc   3540

atgatggcgg gtgcctgtaa tcccagctac tcgggaggct gaggcaggat agtcgcttga   3600

acccaggagg tggaggttgc aatgagccaa gatcatgcca ctgcactcca gcctggacga   3660

cagagtgaga ctccatcaca agaaaaaaag aactttgtca acctctgtct tagggcgcct   3720

tgtcacaggc ttcgggtcag acggattcaa ccttgcatca gccatttgtt agccaggtca   3780

ctctgttctt tgtctgtaaa tgagattgat cgttgttccc actgagagtg tcagctcctt   3840

cccgtagagc aggcatgatg attgtactca cctctgacac cattgtgagt gccacattcc   3900

ttcccacgtc cttgtcactg taagagatgc ccacctgagc accaacccca ggttatcttc   3960

ccctttgtct tccagccccc cagaaacagc tacgactcaa cctacccaat catttcatca   4020

tcagattgcc actgtctcta gttcaggtct cttgggactg gcactcagaa atctcataat   4080

aaatcctctt gaggcttctc atacactcgt cttcttccaa tcttctttcc ctcaaaatct   4140

catattttgg ttccacttca cccaccgtca ttctccatat cactcccagg agttaggcaa   4200

aaagcccctt ccgttcttcc gtatgttaaa cttagaatca ctctgttccc tgctctgcgt   4260

ttctattttt tgtttttcct ccatttacta gtagcttaac actttctaac agtgttctta   4320

ttattgatac gtatctatct cttccataag cttataaggt cacggataat acttctcatt   4380

gtagtacgta aatgacgtgg gctagatatg agttgaataa acagttatac ctgtaaattc   4440

ttacagagtg aaaataaatt gttatacttt acaatttgtt tctctcttta gaccatttcc   4500

aggacttgtg attaataacc gtgagtattt tgtgaagtgt tttgtttttg ttttttcctg   4560

gggtctgacg tgtgtgcgtg tgagtgtgta tacatgctta acgtatatca cgttacttca   4620

cctatgtcag taaccaggcc aaatacttgt tttagccctc agtaaaaaca ccaggcactt   4680

cctagttgta aaattattca agcttcttaa cttcctatcc tcgatgcact taatcataaa   4740

atggtaataa tagcaccgat tttgggggag tcgttccagt agatggaaag catctggaac   4800

aggtgtcagc aagctcctgc cgacgtgtat gcataaagtt ttattgaaac caccatcgtg   4860

tccatttgtt tatggcagaa ctgagagatg gcagcagcaa gtgtgtgcct gcaaaaccta   4920

aaatatttac taattggctc tgcaagaaaa gagtttgcat ccccctaacc tagaacagtg   4980

tctagcctct agtatgtgtt tagcctacag tatgtgctca gcgaatacaa tctatattta   5040

ttactgcttt tatgactgtt ataattactg tgcttggatt tcgttacaaa gtaagtcaca   5100

atgtgcctgc ttctgttagt atttcagcac agtgcctggc acacatgggg ctctcaaata   5160

ttgctgagcg agtgaacaaa tgtcctttca attccttaac gttgatgtca ttttcaatag   5220

tattttgagc caaacttaat tttgcgagtg tgttttgttt tcttaacttt attattaaaa   5280

atgtataaaa gtgaggccag gcgtggtggc tcacgcctgt aatcccagca gtttgggagg   5340

ctgaggcagg cggatcagtt gaggttggga gttggagacc agcccgtcca acatggtgaa   5400

agcctgtctc tactaaaaat acaaaaatca gctgggtgtg gtggcgcgtg cctgtaatcc   5460

cagctactca ggaggctgag gcaggagagt tgcttgaatc ctagaggtgg aggttgcagt   5520

gagctgagat cgtgccattg cactccagcc tgggcaacaa gagcaaaact ctgtcccaat   5580

aaataaataa ataaaatgtt ctcttttgtt cctgttcttg tgcggtagtg tggtatagag   5640

ttttatggta attactgtga attagtgatt ctgagggaca tatcagaact ctgaggtttg   5700

tttccttctc atcttgaggg aaacagcaaa tgtatgttaa aatgcttttc caagggaaca   5760

acacatcctt acattattta aaccaatctg cttcattttc agagctggtt gatcagagtg   5820

agtcagaagg ccccgtgata caagaatcag ctgaaccaag ccagttggaa gttccagcca   5880

cagaagaaat aaaagagact gatggaagct ctcagatcaa gcaagaacca gaccccacgt   5940

ggtagacctc ttccctccta gggtaaatca gcttctgtgt cagggatgct gtgtggtgtc   6000

catctgaacc ccctgcatac gcgtagctaa tgtgatctcc ccactttcac ataagatggt   6060

ggccctgcct tcagggaatg tgggagccag gtgggagcct tcccggatat ttaagctaga   6120

agattctaca gggagattct ccttggatca atatatgtct ctcagtcaaa gatgtaaaag   6180

cacttttgcc ttaaaaagaa tgttctgttt ctaaatagag tcaacgttgt cctcctcatt   6240

ggaattcact atgagtcaga atcattagac tgactttttt ttttccatag taatagtatt   6300

ttgcagagtc tcacagagct gcagatcttt tgttcatctt gcagagttaa caagtctgat   6360

cctgttagtc cagatttctt aaatttggcc aagttataat aggagcagta gcttgagacc   6420

cgaagtcagg aaactttgac aatggatttt tttttttaat ccagagactt gtactggaat   6480

ttgccttacc ctgtcagctc atggacttaa ggtttcatcc cgctttatga gtgcttctga   6540

atccaagtca ttgttacctg aatttgcaaa ttaagttgtg atattcgtga ctgttaaatt   6600

cctgtaatta gattaacctc tttgcttgct tgtttgtttt ctctcctatt ttagcttaaa   6660

gtatcagtgg ttgagaagag cttttcggac ctgttactac cccaagctgt gtaatatact   6720

tgtataacag aaataccttc tatacaaacc tttttttcta cttttagata gaaatgtcta   6780

ctttttcagc agttctgtga attaaagagc agagtgactg tgggtctgga atggctggtg   6840

tacttgggaa tgtactatca ggattttaca gcaatgctgg gaaatgacag ggaaaatgac   6900

aggaatgaat ctcaccagat tttttatgta ctcagcagag ccttgagtta cggtgtttat   6960

tttccaatca agtgaagata tctcctactt ctcctactgg aacatctcag cttctgcagt   7020

gaagaaaaat tcctgtgata gttcagttct ttagtttttc tatttgaaaa aaaaaaatca   7080

tttaaatgat cctttgttca cggctctcct taatgactga gtgaacagtt cctatctgta   7140

tatttgacta aaccttttcc taagctatct ctcatggttc ctatgttttt ttatcataat   7200

taaaagcaaa accatctgga tcacctaaca gtcagaggtc agtatctcag cgtgtgaatt   7260

atagaggaaa tacagagaga acctcttcca cttttacttt tcgtccaaat aaaatgcatg   7320

gtgtaccaga agttgaagat cgggttgagg attggggcta gctcgatgac actaaggccc   7380

caacatcgcg ggacctgctg tggcgcggat tcttaggaac gctgttctag ccggccccct   7440

ctccaggggt cgccgtggcc ggcattattt cctagttctt cttgtaaccc tgaggtgcca   7500

gcgcggggag tgaggagggg tcagggggct aaggatgcaa cctctgacgt tctgcgcctt   7560

cctaggagag tcttacatgt gttgagattt cacaagcaat gcgagttgta aaataccagc   7620

tctacaagaa gctaggctct gtgacggcat agttttcagt agctttatca caatattcac   7680

aatggagaat tatatgacat ggtagcagaa ataggccctt ttatgtgttg cttctatttt   7740

acctcaaatt gtagatatag ggtaatcaat aaaatccatc catgcctttc acacactaag   7800

t                                                                   7801


<210>  4859
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  4859

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
    450                 455                 460


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
465                 470                 475                 480


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
                485                 490                 495


Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys 
            500                 505                 510


Asn Leu Asn 
        515


<210>  4860
<211>  4083
<212>  DNA
<213>  Homo sapiens

<400>  4860
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagctca agctcttgga ctcaccgagg   1980

cagtaaaagt accatatcct gtgtttgaat caaacccgga gttcttgtat gtggaaggct   2040

tgccagaggg gattcccttc cgaagcccta cctggtttgg aattccacga cttgaaagga   2100

tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa acctgaacta gttatttcct   2160

acttgcctcc tgggatggct agtaaaataa acactaaagc tttgcagtcc cccaaaagac   2220

cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta   2280

ataacaacaa tcctcaaacc tcagctgttc gaaccccgac ccagactaac ggttctaacg   2340

ttcccttcaa gccacgaggg agagagtttt cctttgaggc ctggaatgcc aaaatcacgg   2400

acctaaaaca gaaagttgaa aatctcttca atgagaaatg tggggaagct cttggcctta   2460

aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg   2520

aaggcttacc tgagggtgtg ccattccgaa gaccatcgac ttttggcatt ccgaggctgg   2580

agaagatact cagaaacaaa gccaaaatta agttcatcat taaaaagccc gaaatgtttg   2640

agacggcgat taaggagagc acctcctcta agagccctcc cagaaaaata aattcatcac   2700

ccaatgttaa tactactgca tcaggtgttg aagaccttaa catcattcag gtgacaattc   2760

cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta agagaacaag   2820

tgaatgacct ctttagtcgg aaatttggtg aagctattgg tatgggtttt cctgtgaaag   2880

ttccctacag gaaaatcaca attaaccctg gctgtgtggt ggttgatggc atgcccccgg   2940

gggtgtcctt caaagccccc agctacctgg aaatcagctc catgagaagg atcttagact   3000

ctgccgagtt tatcaaattc acggtcatta gaccatttcc aggacttgtg attaataacc   3060

agctggttga tcagagtgag tcagaaggcc ccgtgataca agaatcagct gaaccaagcc   3120

agttggaagt tccagccaca gaagaaataa aagagactga tggaagctct cagatcaagc   3180

aagaaccaga ccccacgtgg tagacctctt ccctcctagg agccttgagt tacggtgttt   3240

attttccaat caagtgaaga tatctcctac ttctcctact ggaacatctc agcttctgca   3300

gtgaagaaaa attcctgtga tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat   3360

catttaaatg atcctttgtt cacggctctc cttaatgact gagtgaacag ttcctatctg   3420

tatatttgac taaacctttt cctaagctat ctctcatggt tcctatgttt ttttatcata   3480

attaaaagca aaaccatctg gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa   3540

ttatagagga aatacagaga gaacctcttc cacttttact tttcgtccaa ataaaatgca   3600

tggtgtacca gaagttgaag atcgggttga ggattggggc tagctcgatg acactaaggc   3660

cccaacatcg cgggacctgc tgtggcgcgg attcttagga acgctgttct agccggcccc   3720

ctctccaggg gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac cctgaggtgc   3780

cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc   3840

ttcctaggag agtcttacat gtgttgagat ttcacaagca atgcgagttg taaaatacca   3900

gctctacaag aagctaggct ctgtgacggc atagttttca gtagctttat cacaatattc   3960

acaatggaga attatatgac atggtagcag aaataggccc ttttatgtgt tgcttctatt   4020

ttacctcaaa ttgtagatat agggtaatca ataaaatcca tccatgcctt tcacacacta   4080

agt                                                                 4083


<210>  4861
<211>  933
<212>  PRT
<213>  Homo sapiens

<400>  4861

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
        515                 520                 525


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
    530                 535                 540


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
545                 550                 555                 560


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
                565                 570                 575


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
            580                 585                 590


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
        595                 600                 605


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
    610                 615                 620


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
625                 630                 635                 640


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
                645                 650                 655


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
            660                 665                 670


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
        675                 680                 685


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
    690                 695                 700


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
705                 710                 715                 720


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
                725                 730                 735


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
            740                 745                 750


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
        755                 760                 765


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
    770                 775                 780


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
785                 790                 795                 800


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
                805                 810                 815


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
            820                 825                 830


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
        835                 840                 845


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
    850                 855                 860


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro 
865                 870                 875                 880


Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly 
                885                 890                 895


Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala 
            900                 905                 910


Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu 
        915                 920                 925


Pro Asp Pro Thr Trp 
    930


<210>  4862
<211>  7034
<212>  DNA
<213>  Homo sapiens

<400>  4862
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1860

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1920

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1980

aatcaaaccc ggagttcttg aaaggatcgt ccgcgggagt aataaaatca agttcgttgt   2040

taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta aaataaacac   2100

taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa aggttcctga   2160

aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag ctgttcgaac   2220

cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag agttttcctt   2280

tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc tcttcaatga   2340

gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg cgttatttga   2400

gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat tccgaagacc   2460

atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca aaattaagtt   2520

catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct cctctaagag   2580

ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag gtgttgaaga   2640

ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct cgaaagttga   2700

aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat ttggtgaagc   2760

tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta accctggctg   2820

tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct acctggaaat   2880

cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg tcattaggta   2940

agtgagagtt tcctgcttag tcacaggagc gaatctggag ctcatgaggc tgactcttct   3000

aaaatgcagc cacaggtagt catcgaatcc ggcttcctat gctgtgcaat caacaaatca   3060

aaataacttg tgtcatcatt agaatgtcag atgtgcttct acgaactaag ctgactcttt   3120

taattctttg gcaaagggtt ggcaaactag gactgtttgc caaattcagg ctgcctccta   3180

tttttagagt cttcctgaaa cacagctaca cccgtattat ccatggctgc tttcctgtca   3240

cagtgagtaa gtagctggga ctgagaaggc atggcctcca aagtctaaaa tatttactct   3300

ctagcacttt gtagaaaaac cttagctagg cacagtggct aacgcctgta atcccagcat   3360

tttgggaggc caaggcaggc agatcacctg aggtcaggag ttccagacca gcctggccaa   3420

catggtgaaa tcccatctct acaaaaataa aacagttagc tgggcatgat ggcgggtgcc   3480

tgtaatccca gctactcggg aggctgaggc aggatagtcg cttgaaccca ggaggtggag   3540

gttgcaatga gccaagatca tgccactgca ctccagcctg gacgacagag tgagactcca   3600

tcacaagaaa aaaagaactt tgtcaacctc tgtcttaggg cgccttgtca caggcttcgg   3660

gtcagacgga ttcaaccttg catcagccat ttgttagcca ggtcactctg ttctttgtct   3720

gtaaatgaga ttgatcgttg ttcccactga gagtgtcagc tccttcccgt agagcaggca   3780

tgatgattgt actcacctct gacaccattg tgagtgccac attccttccc acgtccttgt   3840

cactgtaaga gatgcccacc tgagcaccaa ccccaggtta tcttcccctt tgtcttccag   3900

ccccccagaa acagctacga ctcaacctac ccaatcattt catcatcaga ttgccactgt   3960

ctctagttca ggtctcttgg gactggcact cagaaatctc ataataaatc ctcttgaggc   4020

ttctcataca ctcgtcttct tccaatcttc tttccctcaa aatctcatat tttggttcca   4080

cttcacccac cgtcattctc catatcactc ccaggagtta ggcaaaaagc cccttccgtt   4140

cttccgtatg ttaaacttag aatcactctg ttccctgctc tgcgtttcta ttttttgttt   4200

ttcctccatt tactagtagc ttaacacttt ctaacagtgt tcttattatt gatacgtatc   4260

tatctcttcc ataagcttat aaggtcacgg ataatacttc tcattgtagt acgtaaatga   4320

cgtgggctag atatgagttg aataaacagt tatacctgta aattcttaca gagtgaaaat   4380

aaattgttat actttacaat ttgtttctct ctttagacca tttccaggac ttgtgattaa   4440

taaccgtgag tattttgtga agtgttttgt ttttgttttt tcctggggtc tgacgtgtgt   4500

gcgtgtgagt gtgtatacat gcttaacgta tatcacgtta cttcacctat gtcagtaacc   4560

aggccaaata cttgttttag ccctcagtaa aaacaccagg cacttcctag ttgtaaaatt   4620

attcaagctt cttaacttcc tatcctcgat gcacttaatc ataaaatggt aataatagca   4680

ccgattttgg gggagtcgtt ccagtagatg gaaagcatct ggaacaggtg tcagcaagct   4740

cctgccgacg tgtatgcata aagttttatt gaaaccacca tcgtgtccat ttgtttatgg   4800

cagaactgag agatggcagc agcaagtgtg tgcctgcaaa acctaaaata tttactaatt   4860

ggctctgcaa gaaaagagtt tgcatccccc taacctagaa cagtgtctag cctctagtat   4920

gtgtttagcc tacagtatgt gctcagcgaa tacaatctat atttattact gcttttatga   4980

ctgttataat tactgtgctt ggatttcgtt acaaagtaag tcacaatgtg cctgcttctg   5040

ttagtatttc agcacagtgc ctggcacaca tggggctctc aaatattgct gagcgagtga   5100

acaaatgtcc tttcaattcc ttaacgttga tgtcattttc aatagtattt tgagccaaac   5160

ttaattttgc gagtgtgttt tgttttctta actttattat taaaaatgta taaaagtgag   5220

gccaggcgtg gtggctcacg cctgtaatcc cagcagtttg ggaggctgag gcaggcggat   5280

cagttgaggt tgggagttgg agaccagccc gtccaacatg gtgaaagcct gtctctacta   5340

aaaatacaaa aatcagctgg gtgtggtggc gcgtgcctgt aatcccagct actcaggagg   5400

ctgaggcagg agagttgctt gaatcctaga ggtggaggtt gcagtgagct gagatcgtgc   5460

cattgcactc cagcctgggc aacaagagca aaactctgtc ccaataaata aataaataaa   5520

atgttctctt ttgttcctgt tcttgtgcgg tagtgtggta tagagtttta tggtaattac   5580

tgtgaattag tgattctgag ggacatatca gaactctgag gtttgtttcc ttctcatctt   5640

gagggaaaca gcaaatgtat gttaaaatgc ttttccaagg gaacaacaca tccttacatt   5700

atttaaacca atctgcttca ttttcagagc tggttgatca gagtgagtca gaaggccccg   5760

tgatacaaga atcagctgaa ccaagccagt tggaagttcc agccacagaa gaaataaaag   5820

agactgatgg aagctctcag atcaagcaag aaccagaccc cacgtggtag acctcttccc   5880

tcctaggctt aaagtatcag tggttgagaa gagcttttcg gacctgttac taccccaagc   5940

tgtgtaatat acttgtataa cagaaatacc ttctatacaa accttttttt ctacttttag   6000

atagaaatgt ctactttttc agcagttctg tgaattaaag agcagagtga ctgtgggtct   6060

ggaatggctg gtgtacttgg gaatgtacta tcaggatttt acagcaatgc tgggaaatga   6120

cagggaaaat gacaggaatg aatctcacca gattttttat gtactcagca gagccttgag   6180

ttacggtgtt tattttccaa tcaagtgaag atatctccta cttctcctac tggaacatct   6240

cagcttctgc agtgaagaaa aattcctgtg atagttcagt tctttagttt ttctatttga   6300

aaaaaaaaaa tcatttaaat gatcctttgt tcacggctct ccttaatgac tgagtgaaca   6360

gttcctatct gtatatttga ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt   6420

tttttatcat aattaaaagc aaaaccatct ggatcaccta acagtcagag gtcagtatct   6480

cagcgtgtga attatagagg aaatacagag agaacctctt ccacttttac ttttcgtcca   6540

aataaaatgc atggtgtacc agaagttgaa gatcgggttg aggattgggg ctagctcgat   6600

gacactaagg ccccaacatc gcgggacctg ctgtggcgcg gattcttagg aacgctgttc   6660

tagccggccc cctctccagg ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa   6720

ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg gctaaggatg caacctctga   6780

cgttctgcgc cttcctagga gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt   6840

gtaaaatacc agctctacaa gaagctaggc tctgtgacgg catagttttc agtagcttta   6900

tcacaatatt cacaatggag aattatatga catggtagca gaaataggcc cttttatgtg   6960

ttgcttctat tttacctcaa attgtagata tagggtaatc aataaaatcc atccatgcct   7020

ttcacacact aagt                                                     7034


<210>  4863
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  4863

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg 
            420                 425                 430


Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe 
        435                 440                 445


Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val 
    450                 455                 460


Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile 
465                 470                 475                 480


Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
                485                 490


<210>  4864
<211>  5147
<212>  DNA
<213>  Homo sapiens

<400>  4864
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2040

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2100

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2160

tgaatcaaac ccggagttct tgaaaggatc gtccgcggga gtaataaaat caagttcgtt   2220

gttaaaaaac ctgaactagt tatttcctac ttgcctcctg ggatggctag taaaataaac   2280

actaaagctt tgcagtcccc caaaagacca cgaagtcctg ggagtaattc aaaggttcct   2340

gaaattgagg tcaccgtgga aggccctaat aacaacaatc ctcaaacctc agctgttcga   2400

accccgaccc agactaacgg ttctaacgtt cccttcaagc cacgagggag agagttttcc   2460

tttgaggcct ggaatgccaa aatcacggac ctaaaacaga aagttgaaaa tctcttcaat   2520

gagaaatgtg gggaagctct tggccttaaa caagctgtga aggtgccgtt cgcgttattt   2580

gagtctttcc cggaagactt ttatgtggaa ggcttacctg agggtgtgcc attccgaaga   2640

ccatcgactt ttggcattcc gaggctggag aagatactca gaaacaaagc caaaattaag   2700

ttcatcatta aaaagcccga aatgtttgag acggcgatta aggagagcac ctcctctaag   2760

agccctccca gaaaaataaa ttcatcaccc aatgttaata ctactgcatc aggtgttgaa   2820

gaccttaaca tcattcaggt gacaattcca gatgatgata atgaaagact ctcgaaagtt   2880

gaaaaagcta gacagctaag agaacaagtg aatgacctct ttagtcggaa atttggtgaa   2940

gctattggta tgggttttcc tgtgaaagtt ccctacagga aaatcacaat taaccctggc   3000

tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca aagcccccag ctacctggaa   3060

atcagctcca tgagaaggat cttagactct gccgagttta tcaaattcac ggtcattaga   3120

ccatttccag gacttgtgat taataaccag ctggttgatc agagtgagtc agaaggcccc   3180

gtgatacaag aatcagctga accaagccag ttggaagttc cagccacaga agaaataaaa   3240

gagactgatg gaagctctca gatcaagcaa gaaccagacc ccacgtggta gacctcttcc   3300

ctcctagggt aaatcagctt ctgtgtcagg gatgctgtgt ggtgtccatc tgaaccccct   3360

gcatacgcgt agctaatgtg atctccccac tttcacataa gatggtggcc ctgccttcag   3420

ggaatgtggg agccaggtgg gagccttccc ggatatttaa gctagaagat tctacaggga   3480

gattctcctt ggatcaatat atgtctctca gtcaaagatg taaaagcact tttgccttaa   3540

aaagaatgtt ctgtttctaa atagagtcaa cgttgtcctc ctcattggaa ttcactatga   3600

gtcagaatca ttagactgac tttttttttt ccatagtaat agtattttgc agagtctcac   3660

agagctgcag atcttttgtt catcttgcag agttaacaag tctgatcctg ttagtccaga   3720

tttcttaaat ttggccaagt tataatagga gcagtagctt gagacccgaa gtcaggaaac   3780

tttgacaatg gatttttttt tttaatccag agacttgtac tggaatttgc cttaccctgt   3840

cagctcatgg acttaaggtt tcatcccgct ttatgagtgc ttctgaatcc aagtcattgt   3900

tacctgaatt tgcaaattaa gttgtgatat tcgtgactgt taaattcctg taattagatt   3960

aacctctttg cttgcttgtt tgttttctct cctattttag cttaaagtat cagtggttga   4020

gaagagcttt tcggacctgt tactacccca agctgtgtaa tatacttgta taacagaaat   4080

accttctata caaacctttt tttctacttt tagatagaaa tgtctacttt ttcagcagtt   4140

ctgtgaatta aagagcagag tgactgtggg tctggaatgg ctggtgtact tgggaatgta   4200

ctatcaggat tttacagcaa tgctgggaaa tgacagggaa aatgacagga atgaatctca   4260

ccagattttt tatgtactca gcagagcctt gagttacggt gtttattttc caatcaagtg   4320

aagatatctc ctacttctcc tactggaaca tctcagcttc tgcagtgaag aaaaattcct   4380

gtgatagttc agttctttag tttttctatt tgaaaaaaaa aaatcattta aatgatcctt   4440

tgttcacggc tctccttaat gactgagtga acagttccta tctgtatatt tgactaaacc   4500

ttttcctaag ctatctctca tggttcctat gtttttttat cataattaaa agcaaaacca   4560

tctggatcac ctaacagtca gaggtcagta tctcagcgtg tgaattatag aggaaataca   4620

gagagaacct cttccacttt tacttttcgt ccaaataaaa tgcatggtgt accagaagtt   4680

gaagatcggg ttgaggattg gggctagctc gatgacacta aggccccaac atcgcgggac   4740

ctgctgtggc gcggattctt aggaacgctg ttctagccgg ccccctctcc aggggtcgcc   4800

gtggccggca ttatttccta gttcttcttg taaccctgag gtgccagcgc ggggagtgag   4860

gaggggtcag ggggctaagg atgcaacctc tgacgttctg cgccttccta ggagagtctt   4920

acatgtgttg agatttcaca agcaatgcga gttgtaaaat accagctcta caagaagcta   4980

ggctctgtga cggcatagtt ttcagtagct ttatcacaat attcacaatg gagaattata   5040

tgacatggta gcagaaatag gcccttttat gtgttgcttc tattttacct caaattgtag   5100

atatagggta atcaataaaa tccatccatg cctttcacac actaagt                 5147


<210>  4865
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  4865

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala 
            580                 585                 590


Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600                 605


<210>  4866
<211>  7228
<212>  DNA
<213>  Homo sapiens

<400>  4866
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgcttaga tttgttgaca gcggtttcct ggagtgctgt   1980

cttgagaacg attctgagga ggctcagcaa gaaagagtgt ttcagttgat tgggtgtgtc   2040

tgtcatggag aaggaactca agctcttgga ctcaccgagg cagtaaaagt accatatcct   2100

gtgtttgaat caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc   2160

cgaagcccta cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa   2220

atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct   2280

agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat   2340

tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc   2400

tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg   2460

agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa   2520

aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg   2580

ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg   2640

ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa   2700

gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc   2760

acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca   2820

tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga   2880

ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg   2940

aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca   3000

attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt caaagccccc   3060

agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc   3120

acggtcatta ggtaagtgag agtttcctgc ttagtcacag gagcgaatct ggagctcatg   3180

aggctgactc ttctaaaatg cagccacagg tagtcatcga atccggcttc ctatgctgtg   3240

caatcaacaa atcaaaataa cttgtgtcat cattagaatg tcagatgtgc ttctacgaac   3300

taagctgact cttttaattc tttggcaaag ggttggcaaa ctaggactgt ttgccaaatt   3360

caggctgcct cctattttta gagtcttcct gaaacacagc tacacccgta ttatccatgg   3420

ctgctttcct gtcacagtga gtaagtagct gggactgaga aggcatggcc tccaaagtct   3480

aaaatattta ctctctagca ctttgtagaa aaaccttagc taggcacagt ggctaacgcc   3540

tgtaatccca gcattttggg aggccaaggc aggcagatca cctgaggtca ggagttccag   3600

accagcctgg ccaacatggt gaaatcccat ctctacaaaa ataaaacagt tagctgggca   3660

tgatggcggg tgcctgtaat cccagctact cgggaggctg aggcaggata gtcgcttgaa   3720

cccaggaggt ggaggttgca atgagccaag atcatgccac tgcactccag cctggacgac   3780

agagtgagac tccatcacaa gaaaaaaaga actttgtcaa cctctgtctt agggcgcctt   3840

gtcacaggct tcgggtcaga cggattcaac cttgcatcag ccatttgtta gccaggtcac   3900

tctgttcttt gtctgtaaat gagattgatc gttgttccca ctgagagtgt cagctccttc   3960

ccgtagagca ggcatgatga ttgtactcac ctctgacacc attgtgagtg ccacattcct   4020

tcccacgtcc ttgtcactgt aagagatgcc cacctgagca ccaaccccag gttatcttcc   4080

cctttgtctt ccagcccccc agaaacagct acgactcaac ctacccaatc atttcatcat   4140

cagattgcca ctgtctctag ttcaggtctc ttgggactgg cactcagaaa tctcataata   4200

aatcctcttg aggcttctca tacactcgtc ttcttccaat cttctttccc tcaaaatctc   4260

atattttggt tccacttcac ccaccgtcat tctccatatc actcccagga gttaggcaaa   4320

aagccccttc cgttcttccg tatgttaaac ttagaatcac tctgttccct gctctgcgtt   4380

tctatttttt gtttttcctc catttactag tagcttaaca ctttctaaca gtgttcttat   4440

tattgatacg tatctatctc ttccataagc ttataaggtc acggataata cttctcattg   4500

tagtacgtaa atgacgtggg ctagatatga gttgaataaa cagttatacc tgtaaattct   4560

tacagagtga aaataaattg ttatacttta caatttgttt ctctctttag accatttcca   4620

ggacttgtga ttaataaccg tgagtatttt gtgaagtgtt ttgtttttgt tttttcctgg   4680

ggtctgacgt gtgtgcgtgt gagtgtgtat acatgcttaa cgtatatcac gttacttcac   4740

ctatgtcagt aaccaggcca aatacttgtt ttagccctca gtaaaaacac caggcacttc   4800

ctagttgtaa aattattcaa gcttcttaac ttcctatcct cgatgcactt aatcataaaa   4860

tggtaataat agcaccgatt ttgggggagt cgttccagta gatggaaagc atctggaaca   4920

ggtgtcagca agctcctgcc gacgtgtatg cataaagttt tattgaaacc accatcgtgt   4980

ccatttgttt atggcagaac tgagagatgg cagcagcaag tgtgtgcctg caaaacctaa   5040

aatatttact aattggctct gcaagaaaag agtttgcatc cccctaacct agaacagtgt   5100

ctagcctcta gtatgtgttt agcctacagt atgtgctcag cgaatacaat ctatatttat   5160

tactgctttt atgactgtta taattactgt gcttggattt cgttacaaag taagtcacaa   5220

tgtgcctgct tctgttagta tttcagcaca gtgcctggca cacatggggc tctcaaatat   5280

tgctgagcga gtgaacaaat gtcctttcaa ttccttaacg ttgatgtcat tttcaatagt   5340

attttgagcc aaacttaatt ttgcgagtgt gttttgtttt cttaacttta ttattaaaaa   5400

tgtataaaag tgaggccagg cgtggtggct cacgcctgta atcccagcag tttgggaggc   5460

tgaggcaggc ggatcagttg aggttgggag ttggagacca gcccgtccaa catggtgaaa   5520

gcctgtctct actaaaaata caaaaatcag ctgggtgtgg tggcgcgtgc ctgtaatccc   5580

agctactcag gaggctgagg caggagagtt gcttgaatcc tagaggtgga ggttgcagtg   5640

agctgagatc gtgccattgc actccagcct gggcaacaag agcaaaactc tgtcccaata   5700

aataaataaa taaaatgttc tcttttgttc ctgttcttgt gcggtagtgt ggtatagagt   5760

tttatggtaa ttactgtgaa ttagtgattc tgagggacat atcagaactc tgaggtttgt   5820

ttccttctca tcttgaggga aacagcaaat gtatgttaaa atgcttttcc aagggaacaa   5880

cacatcctta cattatttaa accaatctgc ttcattttca gagctggttg atcagagtga   5940

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   6000

agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag accccacgtg   6060

gtagacctct tccctcctag gcttaaagta tcagtggttg agaagagctt ttcggacctg   6120

ttactacccc aagctgtgta atatacttgt ataacagaaa taccttctat acaaaccttt   6180

ttttctactt ttagatagaa atgtctactt tttcagcagt tctgtgaatt aaagagcaga   6240

gtgactgtgg gtctggaatg gctggtgtac ttgggaatgt actatcagga ttttacagca   6300

atgctgggaa atgacaggga aaatgacagg aatgaatctc accagatttt ttatgtactc   6360

agcagagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct cctacttctc   6420

ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta   6480

gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg ctctccttaa   6540

tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa gctatctctc   6600

atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca cctaacagtc   6660

agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc tcttccactt   6720

ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg gttgaggatt   6780

ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg cgcggattct   6840

taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc attatttcct   6900

agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca gggggctaag   6960

gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt gagatttcac   7020

aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg acggcatagt   7080

tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt agcagaaata   7140

ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt aatcaataaa   7200

atccatccat gcctttcaca cactaagt                                      7228


<210>  4867
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  4867

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
            420                 425                 430


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
        435                 440                 445


Phe Asn Leu Lys Phe Ala 
    450


<210>  4868
<211>  4149
<212>  DNA
<213>  Homo sapiens

<400>  4868
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gtcaaagaag attggaatgt   1980

cagaattacc aagctacgga agcaagtgga agagattttt aatttgaaat ttgctcaagc   2040

tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt   2100

cttgaaagga tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa acctgaacta   2160

gttatttcct acttgcctcc tgggatggct agtaaaataa acactaaagc tttgcagtcc   2220

cccaaaagac cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg   2280

gaaggcccta ataacaacaa tcctcaaacc tcagctgttc gaaccccgac ccagactaac   2340

ggttctaacg ttcccttcaa gccacgaggg agagagtttt cctttgaggc ctggaatgcc   2400

aaaatcacgg acctaaaaca gaaagttgaa aatctcttca atgagaaatg tggggaagct   2460

cttggcctta aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac   2520

ttttatgtgg aaggcttacc tgagggtgtg ccattccgaa gaccatcgac ttttggcatt   2580

ccgaggctgg agaagatact cagaaacaaa gccaaaatta agttcatcat taaaaagccc   2640

gaaatgtttg agacggcgat taaggagagc acctcctcta agagccctcc cagaaaaata   2700

aattcatcac ccaatgttaa tactactgca tcaggtgttg aagaccttaa catcattcag   2760

gtgacaattc cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta   2820

agagaacaag tgaatgacct ctttagtcgg aaatttggtg aagctattgg tatgggtttt   2880

cctgtgaaag ttccctacag gaaaatcaca attaaccctg gctgtgtggt ggttgatggc   2940

atgcccccgg gggtgtcctt caaagccccc agctacctgg aaatcagctc catgagaagg   3000

atcttagact ctgccgagtt tatcaaattc acggtcatta gaccatttcc aggacttgtg   3060

attaataacc agctggttga tcagagtgag tcagaaggcc ccgtgataca agaatcagct   3120

gaaccaagcc agttggaagt tccagccaca gaagaaataa aagagactga tggaagctct   3180

cagatcaagc aagaaccaga ccccacgtgg tagacctctt ccctcctagg cttaaagtat   3240

cagtggttga gaagagcttt tcggacctgt tactacccca agctgtagcc ttgagttacg   3300

gtgtttattt tccaatcaag tgaagatatc tcctacttct cctactggaa catctcagct   3360

tctgcagtga agaaaaattc ctgtgatagt tcagttcttt agtttttcta tttgaaaaaa   3420

aaaaatcatt taaatgatcc tttgttcacg gctctcctta atgactgagt gaacagttcc   3480

tatctgtata tttgactaaa ccttttccta agctatctct catggttcct atgttttttt   3540

atcataatta aaagcaaaac catctggatc acctaacagt cagaggtcag tatctcagcg   3600

tgtgaattat agaggaaata cagagagaac ctcttccact tttacttttc gtccaaataa   3660

aatgcatggt gtaccagaag ttgaagatcg ggttgaggat tggggctagc tcgatgacac   3720

taaggcccca acatcgcggg acctgctgtg gcgcggattc ttaggaacgc tgttctagcc   3780

ggccccctct ccaggggtcg ccgtggccgg cattatttcc tagttcttct tgtaaccctg   3840

aggtgccagc gcggggagtg aggaggggtc agggggctaa ggatgcaacc tctgacgttc   3900

tgcgccttcc taggagagtc ttacatgtgt tgagatttca caagcaatgc gagttgtaaa   3960

ataccagctc tacaagaagc taggctctgt gacggcatag ttttcagtag ctttatcaca   4020

atattcacaa tggagaatta tatgacatgg tagcagaaat aggccctttt atgtgttgct   4080

tctattttac ctcaaattgt agatataggg taatcaataa aatccatcca tgcctttcac   4140

acactaagt                                                           4149


<210>  4869
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  4869

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys 
                565                 570                 575


Asn Leu Asn 



<210>  4870
<211>  7823
<212>  DNA
<213>  Homo sapiens

<400>  4870
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagc tcaagctctt ggactcaccg   1980

aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag   2040

gcttgccaga ggggattccc ttccgaagcc ctacctggtt tggaattcca cgacttgaaa   2100

ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt   2160

cctacttgcc tcctgggatg gctagtaaaa taaacactaa agctttgcag tcccccaaaa   2220

gaccacgaag tcctgggagt aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc   2280

ctaataacaa caatcctcaa acctcagctg ttcgaacccc gacccagact aacggttcta   2340

acgttccctt caagccacga gggagagagt tttcctttga ggcctggaat gccaaaatca   2400

cggacctaaa acagaaagtt gaaaatctct tcaatgagaa atgtggggaa gctcttggcc   2460

ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc tttcccggaa gacttttatg   2520

tggaaggctt acctgagggt gtgccattcc gaagaccatc gacttttggc attccgaggc   2580

tggagaagat actcagaaac aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt   2640

ttgagacggc gattaaggag agcacctcct ctaagagccc tcccagaaaa ataaattcat   2700

cacccaatgt taatactact gcatcaggtg ttgaagacct taacatcatt caggtgacaa   2760

ttccagatga tgataatgaa agactctcga aagttgaaaa agctagacag ctaagagaac   2820

aagtgaatga cctctttagt cggaaatttg gtgaagctat tggtatgggt tttcctgtga   2880

aagttcccta caggaaaatc acaattaacc ctggctgtgt ggtggttgat ggcatgcccc   2940

cgggggtgtc cttcaaagcc cccagctacc tggaaatcag ctccatgaga aggatcttag   3000

actctgccga gtttatcaaa ttcacggtca ttaggtaagt gagagtttcc tgcttagtca   3060

caggagcgaa tctggagctc atgaggctga ctcttctaaa atgcagccac aggtagtcat   3120

cgaatccggc ttcctatgct gtgcaatcaa caaatcaaaa taacttgtgt catcattaga   3180

atgtcagatg tgcttctacg aactaagctg actcttttaa ttctttggca aagggttggc   3240

aaactaggac tgtttgccaa attcaggctg cctcctattt ttagagtctt cctgaaacac   3300

agctacaccc gtattatcca tggctgcttt cctgtcacag tgagtaagta gctgggactg   3360

agaaggcatg gcctccaaag tctaaaatat ttactctcta gcactttgta gaaaaacctt   3420

agctaggcac agtggctaac gcctgtaatc ccagcatttt gggaggccaa ggcaggcaga   3480

tcacctgagg tcaggagttc cagaccagcc tggccaacat ggtgaaatcc catctctaca   3540

aaaataaaac agttagctgg gcatgatggc gggtgcctgt aatcccagct actcgggagg   3600

ctgaggcagg atagtcgctt gaacccagga ggtggaggtt gcaatgagcc aagatcatgc   3660

cactgcactc cagcctggac gacagagtga gactccatca caagaaaaaa agaactttgt   3720

caacctctgt cttagggcgc cttgtcacag gcttcgggtc agacggattc aaccttgcat   3780

cagccatttg ttagccaggt cactctgttc tttgtctgta aatgagattg atcgttgttc   3840

ccactgagag tgtcagctcc ttcccgtaga gcaggcatga tgattgtact cacctctgac   3900

accattgtga gtgccacatt ccttcccacg tccttgtcac tgtaagagat gcccacctga   3960

gcaccaaccc caggttatct tcccctttgt cttccagccc cccagaaaca gctacgactc   4020

aacctaccca atcatttcat catcagattg ccactgtctc tagttcaggt ctcttgggac   4080

tggcactcag aaatctcata ataaatcctc ttgaggcttc tcatacactc gtcttcttcc   4140

aatcttcttt ccctcaaaat ctcatatttt ggttccactt cacccaccgt cattctccat   4200

atcactccca ggagttaggc aaaaagcccc ttccgttctt ccgtatgtta aacttagaat   4260

cactctgttc cctgctctgc gtttctattt tttgtttttc ctccatttac tagtagctta   4320

acactttcta acagtgttct tattattgat acgtatctat ctcttccata agcttataag   4380

gtcacggata atacttctca ttgtagtacg taaatgacgt gggctagata tgagttgaat   4440

aaacagttat acctgtaaat tcttacagag tgaaaataaa ttgttatact ttacaatttg   4500

tttctctctt tagaccattt ccaggacttg tgattaataa ccgtgagtat tttgtgaagt   4560

gttttgtttt tgttttttcc tggggtctga cgtgtgtgcg tgtgagtgtg tatacatgct   4620

taacgtatat cacgttactt cacctatgtc agtaaccagg ccaaatactt gttttagccc   4680

tcagtaaaaa caccaggcac ttcctagttg taaaattatt caagcttctt aacttcctat   4740

cctcgatgca cttaatcata aaatggtaat aatagcaccg attttggggg agtcgttcca   4800

gtagatggaa agcatctgga acaggtgtca gcaagctcct gccgacgtgt atgcataaag   4860

ttttattgaa accaccatcg tgtccatttg tttatggcag aactgagaga tggcagcagc   4920

aagtgtgtgc ctgcaaaacc taaaatattt actaattggc tctgcaagaa aagagtttgc   4980

atccccctaa cctagaacag tgtctagcct ctagtatgtg tttagcctac agtatgtgct   5040

cagcgaatac aatctatatt tattactgct tttatgactg ttataattac tgtgcttgga   5100

tttcgttaca aagtaagtca caatgtgcct gcttctgtta gtatttcagc acagtgcctg   5160

gcacacatgg ggctctcaaa tattgctgag cgagtgaaca aatgtccttt caattcctta   5220

acgttgatgt cattttcaat agtattttga gccaaactta attttgcgag tgtgttttgt   5280

tttcttaact ttattattaa aaatgtataa aagtgaggcc aggcgtggtg gctcacgcct   5340

gtaatcccag cagtttggga ggctgaggca ggcggatcag ttgaggttgg gagttggaga   5400

ccagcccgtc caacatggtg aaagcctgtc tctactaaaa atacaaaaat cagctgggtg   5460

tggtggcgcg tgcctgtaat cccagctact caggaggctg aggcaggaga gttgcttgaa   5520

tcctagaggt ggaggttgca gtgagctgag atcgtgccat tgcactccag cctgggcaac   5580

aagagcaaaa ctctgtccca ataaataaat aaataaaatg ttctcttttg ttcctgttct   5640

tgtgcggtag tgtggtatag agttttatgg taattactgt gaattagtga ttctgaggga   5700

catatcagaa ctctgaggtt tgtttccttc tcatcttgag ggaaacagca aatgtatgtt   5760

aaaatgcttt tccaagggaa caacacatcc ttacattatt taaaccaatc tgcttcattt   5820

tcagagctgg ttgatcagag tgagtcagaa ggccccgtga tacaagaatc agctgaacca   5880

agccagttgg aagttccagc cacagaagaa ataaaagaga ctgatggaag ctctcagatc   5940

aagcaagaac cagaccccac gtggtagacc tcttccctcc tagggtaaat cagcttctgt   6000

gtcagggatg ctgtgtggtg tccatctgaa ccccctgcat acgcgtagct aatgtgatct   6060

ccccactttc acataagatg gtggccctgc cttcagggaa tgtgggagcc aggtgggagc   6120

cttcccggat atttaagcta gaagattcta cagggagatt ctccttggat caatatatgt   6180

ctctcagtca aagatgtaaa agcacttttg ccttaaaaag aatgttctgt ttctaaatag   6240

agtcaacgtt gtcctcctca ttggaattca ctatgagtca gaatcattag actgactttt   6300

ttttttccat agtaatagta ttttgcagag tctcacagag ctgcagatct tttgttcatc   6360

ttgcagagtt aacaagtctg atcctgttag tccagatttc ttaaatttgg ccaagttata   6420

ataggagcag tagcttgaga cccgaagtca ggaaactttg acaatggatt ttttttttta   6480

atccagagac ttgtactgga atttgcctta ccctgtcagc tcatggactt aaggtttcat   6540

cccgctttat gagtgcttct gaatccaagt cattgttacc tgaatttgca aattaagttg   6600

tgatattcgt gactgttaaa ttcctgtaat tagattaacc tctttgcttg cttgtttgtt   6660

ttctctccta ttttagctta aagtatcagt ggttgagaag agcttttcgg acctgttact   6720

accccaagct gtgtaatata cttgtataac agaaatacct tctatacaaa cctttttttc   6780

tacttttaga tagaaatgtc tactttttca gcagttctgt gaattaaaga gcagagtgac   6840

tgtgggtctg gaatggctgg tgtacttggg aatgtactat caggatttta cagcaatgct   6900

gggaaatgac agggaaaatg acaggaatga atctcaccag attttttatg tactcagcag   6960

agccttgagt tacggtgttt attttccaat caagtgaaga tatctcctac ttctcctact   7020

ggaacatctc agcttctgca gtgaagaaaa attcctgtga tagttcagtt ctttagtttt   7080

tctatttgaa aaaaaaaaat catttaaatg atcctttgtt cacggctctc cttaatgact   7140

gagtgaacag ttcctatctg tatatttgac taaacctttt cctaagctat ctctcatggt   7200

tcctatgttt ttttatcata attaaaagca aaaccatctg gatcacctaa cagtcagagg   7260

tcagtatctc agcgtgtgaa ttatagagga aatacagaga gaacctcttc cacttttact   7320

tttcgtccaa ataaaatgca tggtgtacca gaagttgaag atcgggttga ggattggggc   7380

tagctcgatg acactaaggc cccaacatcg cgggacctgc tgtggcgcgg attcttagga   7440

acgctgttct agccggcccc ctctccaggg gtcgccgtgg ccggcattat ttcctagttc   7500

ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc   7560

aacctctgac gttctgcgcc ttcctaggag agtcttacat gtgttgagat ttcacaagca   7620

atgcgagttg taaaatacca gctctacaag aagctaggct ctgtgacggc atagttttca   7680

gtagctttat cacaatattc acaatggaga attatatgac atggtagcag aaataggccc   7740

ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat agggtaatca ataaaatcca   7800

tccatgcctt tcacacacta agt                                           7823


<210>  4871
<211>  878
<212>  PRT
<213>  Homo sapiens

<400>  4871

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala 
        515                 520                 525


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr 
    530                 535                 540


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe 
545                 550                 555                 560


Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys 
                565                 570                 575


Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly 
            580                 585                 590


Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro 
        595                 600                 605


Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val 
    610                 615                 620


Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro 
625                 630                 635                 640


Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu 
                645                 650                 655


Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys 
            660                 665                 670


Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys 
        675                 680                 685


Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp 
    690                 695                 700


Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser 
705                 710                 715                 720


Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys 
                725                 730                 735


Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys 
            740                 745                 750


Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro 
        755                 760                 765


Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln 
    770                 775                 780


Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys 
785                 790                 795                 800


Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe 
                805                 810                 815


Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys 
            820                 825                 830


Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly 
        835                 840                 845


Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg 
    850                 855                 860


Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
865                 870                 875


<210>  4872
<211>  7332
<212>  DNA
<213>  Homo sapiens

<400>  4872
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   1980

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2040

gaaatttgct tagatttgtt gacagcggtt tcctggagtg ctgtcttgag aacgattctg   2100

aggaggctca gcaagaaaga gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa   2160

ctcaagctct tggactcacc gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc   2220

cggagttctt gtatgtggaa ggcttgccag aggggattcc cttccgaagc cctacctggt   2280

ttggaattcc acgacttgaa aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta   2340

aaaaacctga actagttatt tcctacttgc ctcctgggat ggctagtaaa ataaacacta   2400

aagctttgca gtcccccaaa agaccacgaa gtcctgggag taattcaaag gttcctgaaa   2460

ttgaggtcac cgtggaaggc cctaataaca acaatcctca aacctcagct gttcgaaccc   2520

cgacccagac taacggttct aacgttccct tcaagccacg agggagagag ttttcctttg   2580

aggcctggaa tgccaaaatc acggacctaa aacagaaagt tgaaaatctc ttcaatgaga   2640

aatgtgggga agctcttggc cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt   2700

ctttcccgga agacttttat gtggaaggct tacctgaggg tgtgccattc cgaagaccat   2760

cgacttttgg cattccgagg ctggagaaga tactcagaaa caaagccaaa attaagttca   2820

tcattaaaaa gcccgaaatg tttgagacgg cgattaagga gagcacctcc tctaagagcc   2880

ctcccagaaa aataaattca tcacccaatg ttaatactac tgcatcaggt gttgaagacc   2940

ttaacatcat tcaggtgaca attccagatg atgataatga aagactctcg aaagttgaaa   3000

aagctagaca gctaagagaa caagtgaatg acctctttag tcggaaattt ggtgaagcta   3060

ttggtatggg ttttcctgtg aaagttccct acaggaaaat cacaattaac cctggctgtg   3120

tggtggttga tggcatgccc ccgggggtgt ccttcaaagc ccccagctac ctggaaatca   3180

gctccatgag aaggatctta gactctgccg agtttatcaa attcacggtc attaggtaag   3240

tgagagtttc ctgcttagtc acaggagcga atctggagct catgaggctg actcttctaa   3300

aatgcagcca caggtagtca tcgaatccgg cttcctatgc tgtgcaatca acaaatcaaa   3360

ataacttgtg tcatcattag aatgtcagat gtgcttctac gaactaagct gactctttta   3420

attctttggc aaagggttgg caaactagga ctgtttgcca aattcaggct gcctcctatt   3480

tttagagtct tcctgaaaca cagctacacc cgtattatcc atggctgctt tcctgtcaca   3540

gtgagtaagt agctgggact gagaaggcat ggcctccaaa gtctaaaata tttactctct   3600

agcactttgt agaaaaacct tagctaggca cagtggctaa cgcctgtaat cccagcattt   3660

tgggaggcca aggcaggcag atcacctgag gtcaggagtt ccagaccagc ctggccaaca   3720

tggtgaaatc ccatctctac aaaaataaaa cagttagctg ggcatgatgg cgggtgcctg   3780

taatcccagc tactcgggag gctgaggcag gatagtcgct tgaacccagg aggtggaggt   3840

tgcaatgagc caagatcatg ccactgcact ccagcctgga cgacagagtg agactccatc   3900

acaagaaaaa aagaactttg tcaacctctg tcttagggcg ccttgtcaca ggcttcgggt   3960

cagacggatt caaccttgca tcagccattt gttagccagg tcactctgtt ctttgtctgt   4020

aaatgagatt gatcgttgtt cccactgaga gtgtcagctc cttcccgtag agcaggcatg   4080

atgattgtac tcacctctga caccattgtg agtgccacat tccttcccac gtccttgtca   4140

ctgtaagaga tgcccacctg agcaccaacc ccaggttatc ttcccctttg tcttccagcc   4200

ccccagaaac agctacgact caacctaccc aatcatttca tcatcagatt gccactgtct   4260

ctagttcagg tctcttggga ctggcactca gaaatctcat aataaatcct cttgaggctt   4320

ctcatacact cgtcttcttc caatcttctt tccctcaaaa tctcatattt tggttccact   4380

tcacccaccg tcattctcca tatcactccc aggagttagg caaaaagccc cttccgttct   4440

tccgtatgtt aaacttagaa tcactctgtt ccctgctctg cgtttctatt ttttgttttt   4500

cctccattta ctagtagctt aacactttct aacagtgttc ttattattga tacgtatcta   4560

tctcttccat aagcttataa ggtcacggat aatacttctc attgtagtac gtaaatgacg   4620

tgggctagat atgagttgaa taaacagtta tacctgtaaa ttcttacaga gtgaaaataa   4680

attgttatac tttacaattt gtttctctct ttagaccatt tccaggactt gtgattaata   4740

accgtgagta ttttgtgaag tgttttgttt ttgttttttc ctggggtctg acgtgtgtgc   4800

gtgtgagtgt gtatacatgc ttaacgtata tcacgttact tcacctatgt cagtaaccag   4860

gccaaatact tgttttagcc ctcagtaaaa acaccaggca cttcctagtt gtaaaattat   4920

tcaagcttct taacttccta tcctcgatgc acttaatcat aaaatggtaa taatagcacc   4980

gattttgggg gagtcgttcc agtagatgga aagcatctgg aacaggtgtc agcaagctcc   5040

tgccgacgtg tatgcataaa gttttattga aaccaccatc gtgtccattt gtttatggca   5100

gaactgagag atggcagcag caagtgtgtg cctgcaaaac ctaaaatatt tactaattgg   5160

ctctgcaaga aaagagtttg catcccccta acctagaaca gtgtctagcc tctagtatgt   5220

gtttagccta cagtatgtgc tcagcgaata caatctatat ttattactgc ttttatgact   5280

gttataatta ctgtgcttgg atttcgttac aaagtaagtc acaatgtgcc tgcttctgtt   5340

agtatttcag cacagtgcct ggcacacatg gggctctcaa atattgctga gcgagtgaac   5400

aaatgtcctt tcaattcctt aacgttgatg tcattttcaa tagtattttg agccaaactt   5460

aattttgcga gtgtgttttg ttttcttaac tttattatta aaaatgtata aaagtgaggc   5520

caggcgtggt ggctcacgcc tgtaatccca gcagtttggg aggctgaggc aggcggatca   5580

gttgaggttg ggagttggag accagcccgt ccaacatggt gaaagcctgt ctctactaaa   5640

aatacaaaaa tcagctgggt gtggtggcgc gtgcctgtaa tcccagctac tcaggaggct   5700

gaggcaggag agttgcttga atcctagagg tggaggttgc agtgagctga gatcgtgcca   5760

ttgcactcca gcctgggcaa caagagcaaa actctgtccc aataaataaa taaataaaat   5820

gttctctttt gttcctgttc ttgtgcggta gtgtggtata gagttttatg gtaattactg   5880

tgaattagtg attctgaggg acatatcaga actctgaggt ttgtttcctt ctcatcttga   5940

gggaaacagc aaatgtatgt taaaatgctt ttccaaggga acaacacatc cttacattat   6000

ttaaaccaat ctgcttcatt ttcagagctg gttgatcaga gtgagtcaga aggccccgtg   6060

atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag   6120

actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc   6180

ctaggcttaa agtatcagtg gttgagaaga gcttttcgga cctgttacta ccccaagctg   6240

tgtaatatac ttgtataaca gaaatacctt ctatacaaac ctttttttct acttttagat   6300

agaaatgtct actttttcag cagttctgtg aattaaagag cagagtgact gtgggtctgg   6360

aatggctggt gtacttggga atgtactatc aggattttac agcaatgctg ggaaatgaca   6420

gggaaaatga caggaatgaa tctcaccaga ttttttatgt actcagcaga gccttgagtt   6480

acggtgttta ttttccaatc aagtgaagat atctcctact tctcctactg gaacatctca   6540

gcttctgcag tgaagaaaaa ttcctgtgat agttcagttc tttagttttt ctatttgaaa   6600

aaaaaaaatc atttaaatga tcctttgttc acggctctcc ttaatgactg agtgaacagt   6660

tcctatctgt atatttgact aaaccttttc ctaagctatc tctcatggtt cctatgtttt   6720

tttatcataa ttaaaagcaa aaccatctgg atcacctaac agtcagaggt cagtatctca   6780

gcgtgtgaat tatagaggaa atacagagag aacctcttcc acttttactt ttcgtccaaa   6840

taaaatgcat ggtgtaccag aagttgaaga tcgggttgag gattggggct agctcgatga   6900

cactaaggcc ccaacatcgc gggacctgct gtggcgcgga ttcttaggaa cgctgttcta   6960

gccggccccc tctccagggg tcgccgtggc cggcattatt tcctagttct tcttgtaacc   7020

ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc taaggatgca acctctgacg   7080

ttctgcgcct tcctaggaga gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt   7140

aaaataccag ctctacaaga agctaggctc tgtgacggca tagttttcag tagctttatc   7200

acaatattca caatggagaa ttatatgaca tggtagcaga aataggccct tttatgtgtt   7260

gcttctattt tacctcaaat tgtagatata gggtaatcaa taaaatccat ccatgccttt   7320

cacacactaa gt                                                       7332


<210>  4873
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  4873

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  4874
<211>  7283
<212>  DNA
<213>  Homo sapiens

<400>  4874
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2040

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2100

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2160

tgaatcaaac ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag   2220

ccctacctgg tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa   2280

gttcgttgtt aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa   2340

aataaacact aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa   2400

ggttcctgaa attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc   2460

tgttcgaacc ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga   2520

gttttccttt gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct   2580

cttcaatgag aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc   2640

gttatttgag tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt   2700

ccgaagacca tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa   2760

aattaagttc atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc   2820

ctctaagagc cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg   2880

tgttgaagac cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc   2940

gaaagttgaa aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt   3000

tggtgaagct attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa   3060

ccctggctgt gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta   3120

cctggaaatc agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt   3180

cattaggtaa gtgagagttt cctgcttagt cacaggagcg aatctggagc tcatgaggct   3240

gactcttcta aaatgcagcc acaggtagtc atcgaatccg gcttcctatg ctgtgcaatc   3300

aacaaatcaa aataacttgt gtcatcatta gaatgtcaga tgtgcttcta cgaactaagc   3360

tgactctttt aattctttgg caaagggttg gcaaactagg actgtttgcc aaattcaggc   3420

tgcctcctat ttttagagtc ttcctgaaac acagctacac ccgtattatc catggctgct   3480

ttcctgtcac agtgagtaag tagctgggac tgagaaggca tggcctccaa agtctaaaat   3540

atttactctc tagcactttg tagaaaaacc ttagctaggc acagtggcta acgcctgtaa   3600

tcccagcatt ttgggaggcc aaggcaggca gatcacctga ggtcaggagt tccagaccag   3660

cctggccaac atggtgaaat cccatctcta caaaaataaa acagttagct gggcatgatg   3720

gcgggtgcct gtaatcccag ctactcggga ggctgaggca ggatagtcgc ttgaacccag   3780

gaggtggagg ttgcaatgag ccaagatcat gccactgcac tccagcctgg acgacagagt   3840

gagactccat cacaagaaaa aaagaacttt gtcaacctct gtcttagggc gccttgtcac   3900

aggcttcggg tcagacggat tcaaccttgc atcagccatt tgttagccag gtcactctgt   3960

tctttgtctg taaatgagat tgatcgttgt tcccactgag agtgtcagct ccttcccgta   4020

gagcaggcat gatgattgta ctcacctctg acaccattgt gagtgccaca ttccttccca   4080

cgtccttgtc actgtaagag atgcccacct gagcaccaac cccaggttat cttccccttt   4140

gtcttccagc cccccagaaa cagctacgac tcaacctacc caatcatttc atcatcagat   4200

tgccactgtc tctagttcag gtctcttggg actggcactc agaaatctca taataaatcc   4260

tcttgaggct tctcatacac tcgtcttctt ccaatcttct ttccctcaaa atctcatatt   4320

ttggttccac ttcacccacc gtcattctcc atatcactcc caggagttag gcaaaaagcc   4380

ccttccgttc ttccgtatgt taaacttaga atcactctgt tccctgctct gcgtttctat   4440

tttttgtttt tcctccattt actagtagct taacactttc taacagtgtt cttattattg   4500

atacgtatct atctcttcca taagcttata aggtcacgga taatacttct cattgtagta   4560

cgtaaatgac gtgggctaga tatgagttga ataaacagtt atacctgtaa attcttacag   4620

agtgaaaata aattgttata ctttacaatt tgtttctctc tttagaccat ttccaggact   4680

tgtgattaat aaccgtgagt attttgtgaa gtgttttgtt tttgtttttt cctggggtct   4740

gacgtgtgtg cgtgtgagtg tgtatacatg cttaacgtat atcacgttac ttcacctatg   4800

tcagtaacca ggccaaatac ttgttttagc cctcagtaaa aacaccaggc acttcctagt   4860

tgtaaaatta ttcaagcttc ttaacttcct atcctcgatg cacttaatca taaaatggta   4920

ataatagcac cgattttggg ggagtcgttc cagtagatgg aaagcatctg gaacaggtgt   4980

cagcaagctc ctgccgacgt gtatgcataa agttttattg aaaccaccat cgtgtccatt   5040

tgtttatggc agaactgaga gatggcagca gcaagtgtgt gcctgcaaaa cctaaaatat   5100

ttactaattg gctctgcaag aaaagagttt gcatccccct aacctagaac agtgtctagc   5160

ctctagtatg tgtttagcct acagtatgtg ctcagcgaat acaatctata tttattactg   5220

cttttatgac tgttataatt actgtgcttg gatttcgtta caaagtaagt cacaatgtgc   5280

ctgcttctgt tagtatttca gcacagtgcc tggcacacat ggggctctca aatattgctg   5340

agcgagtgaa caaatgtcct ttcaattcct taacgttgat gtcattttca atagtatttt   5400

gagccaaact taattttgcg agtgtgtttt gttttcttaa ctttattatt aaaaatgtat   5460

aaaagtgagg ccaggcgtgg tggctcacgc ctgtaatccc agcagtttgg gaggctgagg   5520

caggcggatc agttgaggtt gggagttgga gaccagcccg tccaacatgg tgaaagcctg   5580

tctctactaa aaatacaaaa atcagctggg tgtggtggcg cgtgcctgta atcccagcta   5640

ctcaggaggc tgaggcagga gagttgcttg aatcctagag gtggaggttg cagtgagctg   5700

agatcgtgcc attgcactcc agcctgggca acaagagcaa aactctgtcc caataaataa   5760

ataaataaaa tgttctcttt tgttcctgtt cttgtgcggt agtgtggtat agagttttat   5820

ggtaattact gtgaattagt gattctgagg gacatatcag aactctgagg tttgtttcct   5880

tctcatcttg agggaaacag caaatgtatg ttaaaatgct tttccaaggg aacaacacat   5940

ccttacatta tttaaaccaa tctgcttcat tttcagagct ggttgatcag agtgagtcag   6000

aaggccccgt gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag   6060

aaataaaaga gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga   6120

cctcttccct cctaggctta aagtatcagt ggttgagaag agcttttcgg acctgttact   6180

accccaagct gtgtaatata cttgtataac agaaatacct tctatacaaa cctttttttc   6240

tacttttaga tagaaatgtc tactttttca gcagttctgt gaattaaaga gcagagtgac   6300

tgtgggtctg gaatggctgg tgtacttggg aatgtactat caggatttta cagcaatgct   6360

gggaaatgac agggaaaatg acaggaatga atctcaccag attttttatg tactcagcag   6420

agccttgagt tacggtgttt attttccaat caagtgaaga tatctcctac ttctcctact   6480

ggaacatctc agcttctgca gtgaagaaaa attcctgtga tagttcagtt ctttagtttt   6540

tctatttgaa aaaaaaaaat catttaaatg atcctttgtt cacggctctc cttaatgact   6600

gagtgaacag ttcctatctg tatatttgac taaacctttt cctaagctat ctctcatggt   6660

tcctatgttt ttttatcata attaaaagca aaaccatctg gatcacctaa cagtcagagg   6720

tcagtatctc agcgtgtgaa ttatagagga aatacagaga gaacctcttc cacttttact   6780

tttcgtccaa ataaaatgca tggtgtacca gaagttgaag atcgggttga ggattggggc   6840

tagctcgatg acactaaggc cccaacatcg cgggacctgc tgtggcgcgg attcttagga   6900

acgctgttct agccggcccc ctctccaggg gtcgccgtgg ccggcattat ttcctagttc   6960

ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc   7020

aacctctgac gttctgcgcc ttcctaggag agtcttacat gtgttgagat ttcacaagca   7080

atgcgagttg taaaatacca gctctacaag aagctaggct ctgtgacggc atagttttca   7140

gtagctttat cacaatattc acaatggaga attatatgac atggtagcag aaataggccc   7200

ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat agggtaatca ataaaatcca   7260

tccatgcctt tcacacacta agt                                           7283


<210>  4875
<211>  922
<212>  PRT
<213>  Homo sapiens

<400>  4875

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu 
            580                 585                 590


Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg 
        595                 600                 605


Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys 
    610                 615                 620


Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys 
625                 630                 635                 640


Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly 
                645                 650                 655


Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn 
            660                 665                 670


Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn 
        675                 680                 685


Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu 
    690                 695                 700


Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu 
705                 710                 715                 720


Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys 
                725                 730                 735


Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu 
            740                 745                 750


Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile 
        755                 760                 765


Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile 
    770                 775                 780


Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser 
785                 790                 795                 800


Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr 
                805                 810                 815


Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro 
            820                 825                 830


Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu 
        835                 840                 845


Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile 
    850                 855                 860


Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn 
865                 870                 875                 880


Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys 
                885                 890                 895


Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser 
            900                 905                 910


Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
        915                 920


<210>  4876
<211>  8087
<212>  DNA
<213>  Homo sapiens

<400>  4876
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2040

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2100

tttgaaattt gcttagattt gttgacagcg gtttcctgga gtgctgtctt gagaacgatt   2160

ctgaggaggc tcagcaagaa agagtgtttc agttgattgg gtgtgtctgt catggagaag   2220

gaactcaagc tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa   2280

acccggagtt cttgtatgtg gaaggcttgc cagaggggat tcccttccga agccctacct   2340

ggtttggaat tccacgactt gaaaggatcg tccgcgggag taataaaatc aagttcgttg   2400

ttaaaaaacc tgaactagtt atttcctact tgcctcctgg gatggctagt aaaataaaca   2460

ctaaagcttt gcagtccccc aaaagaccac gaagtcctgg gagtaattca aaggttcctg   2520

aaattgaggt caccgtggaa ggccctaata acaacaatcc tcaaacctca gctgttcgaa   2580

ccccgaccca gactaacggt tctaacgttc ccttcaagcc acgagggaga gagttttcct   2640

ttgaggcctg gaatgccaaa atcacggacc taaaacagaa agttgaaaat ctcttcaatg   2700

agaaatgtgg ggaagctctt ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg   2760

agtctttccc ggaagacttt tatgtggaag gcttacctga gggtgtgcca ttccgaagac   2820

catcgacttt tggcattccg aggctggaga agatactcag aaacaaagcc aaaattaagt   2880

tcatcattaa aaagcccgaa atgtttgaga cggcgattaa ggagagcacc tcctctaaga   2940

gccctcccag aaaaataaat tcatcaccca atgttaatac tactgcatca ggtgttgaag   3000

accttaacat cattcaggtg acaattccag atgatgataa tgaaagactc tcgaaagttg   3060

aaaaagctag acagctaaga gaacaagtga atgacctctt tagtcggaaa tttggtgaag   3120

ctattggtat gggttttcct gtgaaagttc cctacaggaa aatcacaatt aaccctggct   3180

gtgtggtggt tgatggcatg cccccggggg tgtccttcaa agcccccagc tacctggaaa   3240

tcagctccat gagaaggatc ttagactctg ccgagtttat caaattcacg gtcattaggt   3300

aagtgagagt ttcctgctta gtcacaggag cgaatctgga gctcatgagg ctgactcttc   3360

taaaatgcag ccacaggtag tcatcgaatc cggcttccta tgctgtgcaa tcaacaaatc   3420

aaaataactt gtgtcatcat tagaatgtca gatgtgcttc tacgaactaa gctgactctt   3480

ttaattcttt ggcaaagggt tggcaaacta ggactgtttg ccaaattcag gctgcctcct   3540

atttttagag tcttcctgaa acacagctac acccgtatta tccatggctg ctttcctgtc   3600

acagtgagta agtagctggg actgagaagg catggcctcc aaagtctaaa atatttactc   3660

tctagcactt tgtagaaaaa ccttagctag gcacagtggc taacgcctgt aatcccagca   3720

ttttgggagg ccaaggcagg cagatcacct gaggtcagga gttccagacc agcctggcca   3780

acatggtgaa atcccatctc tacaaaaata aaacagttag ctgggcatga tggcgggtgc   3840

ctgtaatccc agctactcgg gaggctgagg caggatagtc gcttgaaccc aggaggtgga   3900

ggttgcaatg agccaagatc atgccactgc actccagcct ggacgacaga gtgagactcc   3960

atcacaagaa aaaaagaact ttgtcaacct ctgtcttagg gcgccttgtc acaggcttcg   4020

ggtcagacgg attcaacctt gcatcagcca tttgttagcc aggtcactct gttctttgtc   4080

tgtaaatgag attgatcgtt gttcccactg agagtgtcag ctccttcccg tagagcaggc   4140

atgatgattg tactcacctc tgacaccatt gtgagtgcca cattccttcc cacgtccttg   4200

tcactgtaag agatgcccac ctgagcacca accccaggtt atcttcccct ttgtcttcca   4260

gccccccaga aacagctacg actcaaccta cccaatcatt tcatcatcag attgccactg   4320

tctctagttc aggtctcttg ggactggcac tcagaaatct cataataaat cctcttgagg   4380

cttctcatac actcgtcttc ttccaatctt ctttccctca aaatctcata ttttggttcc   4440

acttcaccca ccgtcattct ccatatcact cccaggagtt aggcaaaaag ccccttccgt   4500

tcttccgtat gttaaactta gaatcactct gttccctgct ctgcgtttct attttttgtt   4560

tttcctccat ttactagtag cttaacactt tctaacagtg ttcttattat tgatacgtat   4620

ctatctcttc cataagctta taaggtcacg gataatactt ctcattgtag tacgtaaatg   4680

acgtgggcta gatatgagtt gaataaacag ttatacctgt aaattcttac agagtgaaaa   4740

taaattgtta tactttacaa tttgtttctc tctttagacc atttccagga cttgtgatta   4800

ataaccgtga gtattttgtg aagtgttttg tttttgtttt ttcctggggt ctgacgtgtg   4860

tgcgtgtgag tgtgtataca tgcttaacgt atatcacgtt acttcaccta tgtcagtaac   4920

caggccaaat acttgtttta gccctcagta aaaacaccag gcacttccta gttgtaaaat   4980

tattcaagct tcttaacttc ctatcctcga tgcacttaat cataaaatgg taataatagc   5040

accgattttg ggggagtcgt tccagtagat ggaaagcatc tggaacaggt gtcagcaagc   5100

tcctgccgac gtgtatgcat aaagttttat tgaaaccacc atcgtgtcca tttgtttatg   5160

gcagaactga gagatggcag cagcaagtgt gtgcctgcaa aacctaaaat atttactaat   5220

tggctctgca agaaaagagt ttgcatcccc ctaacctaga acagtgtcta gcctctagta   5280

tgtgtttagc ctacagtatg tgctcagcga atacaatcta tatttattac tgcttttatg   5340

actgttataa ttactgtgct tggatttcgt tacaaagtaa gtcacaatgt gcctgcttct   5400

gttagtattt cagcacagtg cctggcacac atggggctct caaatattgc tgagcgagtg   5460

aacaaatgtc ctttcaattc cttaacgttg atgtcatttt caatagtatt ttgagccaaa   5520

cttaattttg cgagtgtgtt ttgttttctt aactttatta ttaaaaatgt ataaaagtga   5580

ggccaggcgt ggtggctcac gcctgtaatc ccagcagttt gggaggctga ggcaggcgga   5640

tcagttgagg ttgggagttg gagaccagcc cgtccaacat ggtgaaagcc tgtctctact   5700

aaaaatacaa aaatcagctg ggtgtggtgg cgcgtgcctg taatcccagc tactcaggag   5760

gctgaggcag gagagttgct tgaatcctag aggtggaggt tgcagtgagc tgagatcgtg   5820

ccattgcact ccagcctggg caacaagagc aaaactctgt cccaataaat aaataaataa   5880

aatgttctct tttgttcctg ttcttgtgcg gtagtgtggt atagagtttt atggtaatta   5940

ctgtgaatta gtgattctga gggacatatc agaactctga ggtttgtttc cttctcatct   6000

tgagggaaac agcaaatgta tgttaaaatg cttttccaag ggaacaacac atccttacat   6060

tatttaaacc aatctgcttc attttcagag ctggttgatc agagtgagtc agaaggcccc   6120

gtgatacaag aatcagctga accaagccag ttggaagttc cagccacaga agaaataaaa   6180

gagactgatg gaagctctca gatcaagcaa gaaccagacc ccacgtggta gacctcttcc   6240

ctcctagggt aaatcagctt ctgtgtcagg gatgctgtgt ggtgtccatc tgaaccccct   6300

gcatacgcgt agctaatgtg atctccccac tttcacataa gatggtggcc ctgccttcag   6360

ggaatgtggg agccaggtgg gagccttccc ggatatttaa gctagaagat tctacaggga   6420

gattctcctt ggatcaatat atgtctctca gtcaaagatg taaaagcact tttgccttaa   6480

aaagaatgtt ctgtttctaa atagagtcaa cgttgtcctc ctcattggaa ttcactatga   6540

gtcagaatca ttagactgac tttttttttt ccatagtaat agtattttgc agagtctcac   6600

agagctgcag atcttttgtt catcttgcag agttaacaag tctgatcctg ttagtccaga   6660

tttcttaaat ttggccaagt tataatagga gcagtagctt gagacccgaa gtcaggaaac   6720

tttgacaatg gatttttttt tttaatccag agacttgtac tggaatttgc cttaccctgt   6780

cagctcatgg acttaaggtt tcatcccgct ttatgagtgc ttctgaatcc aagtcattgt   6840

tacctgaatt tgcaaattaa gttgtgatat tcgtgactgt taaattcctg taattagatt   6900

aacctctttg cttgcttgtt tgttttctct cctattttag cttaaagtat cagtggttga   6960

gaagagcttt tcggacctgt tactacccca agctgtgtaa tatacttgta taacagaaat   7020

accttctata caaacctttt tttctacttt tagatagaaa tgtctacttt ttcagcagtt   7080

ctgtgaatta aagagcagag tgactgtggg tctggaatgg ctggtgtact tgggaatgta   7140

ctatcaggat tttacagcaa tgctgggaaa tgacagggaa aatgacagga atgaatctca   7200

ccagattttt tatgtactca gcagagcctt gagttacggt gtttattttc caatcaagtg   7260

aagatatctc ctacttctcc tactggaaca tctcagcttc tgcagtgaag aaaaattcct   7320

gtgatagttc agttctttag tttttctatt tgaaaaaaaa aaatcattta aatgatcctt   7380

tgttcacggc tctccttaat gactgagtga acagttccta tctgtatatt tgactaaacc   7440

ttttcctaag ctatctctca tggttcctat gtttttttat cataattaaa agcaaaacca   7500

tctggatcac ctaacagtca gaggtcagta tctcagcgtg tgaattatag aggaaataca   7560

gagagaacct cttccacttt tacttttcgt ccaaataaaa tgcatggtgt accagaagtt   7620

gaagatcggg ttgaggattg gggctagctc gatgacacta aggccccaac atcgcgggac   7680

ctgctgtggc gcggattctt aggaacgctg ttctagccgg ccccctctcc aggggtcgcc   7740

gtggccggca ttatttccta gttcttcttg taaccctgag gtgccagcgc ggggagtgag   7800

gaggggtcag ggggctaagg atgcaacctc tgacgttctg cgccttccta ggagagtctt   7860

acatgtgttg agatttcaca agcaatgcga gttgtaaaat accagctcta caagaagcta   7920

ggctctgtga cggcatagtt ttcagtagct ttatcacaat attcacaatg gagaattata   7980

tgacatggta gcagaaatag gcccttttat gtgttgcttc tattttacct caaattgtag   8040

atatagggta atcaataaaa tccatccatg cctttcacac actaagt                 8087


<210>  4877
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  4877

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala 



<210>  4878
<211>  4442
<212>  DNA
<213>  Homo sapiens

<400>  4878
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   1980

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2040

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2100

tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg tttggaattc   2160

cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg   2220

aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc   2280

agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca   2340

ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga   2400

ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga   2460

atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg   2520

aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg   2580

aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg   2640

gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa   2700

agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa   2760

aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca   2820

ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac   2880

agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg   2940

gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg   3000

atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga   3060

gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca tttccaggac   3120

ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat   3180

cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa   3240

gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc ctaggcttaa   3300

agtatcagtg gttgagaaga gcttttcgga cctgttacta ccccaagctg tgtaatatac   3360

ttgtataaca gaaatacctt ctatacaaac ctttttttct acttttagat agaaatgtct   3420

actttttcag cagttctgtg aattaaagag cagagtgact gtgggtctgg aatggctggt   3480

gtacttggga atgtactatc aggattttac agcaatgctg ggaaatgaca gggaaaatga   3540

caggaatgaa tctcaccaga ttttttatgt actcagcaga gccttgagtt acggtgttta   3600

ttttccaatc aagtgaagat atctcctact tctcctactg gaacatctca gcttctgcag   3660

tgaagaaaaa ttcctgtgat agttcagttc tttagttttt ctatttgaaa aaaaaaaatc   3720

atttaaatga tcctttgttc acggctctcc ttaatgactg agtgaacagt tcctatctgt   3780

atatttgact aaaccttttc ctaagctatc tctcatggtt cctatgtttt tttatcataa   3840

ttaaaagcaa aaccatctgg atcacctaac agtcagaggt cagtatctca gcgtgtgaat   3900

tatagaggaa atacagagag aacctcttcc acttttactt ttcgtccaaa taaaatgcat   3960

ggtgtaccag aagttgaaga tcgggttgag gattggggct agctcgatga cactaaggcc   4020

ccaacatcgc gggacctgct gtggcgcgga ttcttaggaa cgctgttcta gccggccccc   4080

tctccagggg tcgccgtggc cggcattatt tcctagttct tcttgtaacc ctgaggtgcc   4140

agcgcgggga gtgaggaggg gtcagggggc taaggatgca acctctgacg ttctgcgcct   4200

tcctaggaga gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt aaaataccag   4260

ctctacaaga agctaggctc tgtgacggca tagttttcag tagctttatc acaatattca   4320

caatggagaa ttatatgaca tggtagcaga aataggccct tttatgtgtt gcttctattt   4380

tacctcaaat tgtagatata gggtaatcaa taaaatccat ccatgccttt cacacactaa   4440

gt                                                                  4442


<210>  4879
<211>  958
<212>  PRT
<213>  Homo sapiens

<400>  4879

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile 
        515                 520                 525


Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
545                 550                 555                 560


Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile 
                565                 570                 575


Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile 
            580                 585                 590


Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu 
        595                 600                 605


Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys 
    610                 615                 620


Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys 
625                 630                 635                 640


Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro 
                645                 650                 655


Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val 
            660                 665                 670


Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala 
        675                 680                 685


Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys 
    690                 695                 700


Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala 
705                 710                 715                 720


Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu 
                725                 730                 735


Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu 
            740                 745                 750


Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro 
        755                 760                 765


Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro 
    770                 775                 780


Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly 
785                 790                 795                 800


Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn 
                805                 810                 815


Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val 
            820                 825                 830


Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe 
        835                 840                 845


Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val 
    850                 855                 860


Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr 
865                 870                 875                 880


Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile 
                885                 890                 895


Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln 
            900                 905                 910


Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala 
        915                 920                 925


Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr 
    930                 935                 940


Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950                 955


<210>  4880
<211>  7196
<212>  DNA
<213>  Homo sapiens

<400>  4880
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   2040

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2100

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2160

tgaaaggatc gtccgcggga gtaataaaat caagttcgtt gttaaaaaac ctgaactagt   2220

tatttcctac ttgcctcctg ggatggctag taaaataaac actaaagctt tgcagtcccc   2280

caaaagacca cgaagtcctg ggagtaattc aaaggttcct gaaattgagg tcaccgtgga   2340

aggccctaat aacaacaatc ctcaaacctc agctgttcga accccgaccc agactaacgg   2400

ttctaacgtt cccttcaagc cacgagggag agagttttcc tttgaggcct ggaatgccaa   2460

aatcacggac ctaaaacaga aagttgaaaa tctcttcaat gagaaatgtg gggaagctct   2520

tggccttaaa caagctgtga aggtgccgtt cgcgttattt gagtctttcc cggaagactt   2580

ttatgtggaa ggcttacctg agggtgtgcc attccgaaga ccatcgactt ttggcattcc   2640

gaggctggag aagatactca gaaacaaagc caaaattaag ttcatcatta aaaagcccga   2700

aatgtttgag acggcgatta aggagagcac ctcctctaag agccctccca gaaaaataaa   2760

ttcatcaccc aatgttaata ctactgcatc aggtgttgaa gaccttaaca tcattcaggt   2820

gacaattcca gatgatgata atgaaagact ctcgaaagtt gaaaaagcta gacagctaag   2880

agaacaagtg aatgacctct ttagtcggaa atttggtgaa gctattggta tgggttttcc   2940

tgtgaaagtt ccctacagga aaatcacaat taaccctggc tgtgtggtgg ttgatggcat   3000

gcccccgggg gtgtccttca aagcccccag ctacctggaa atcagctcca tgagaaggat   3060

cttagactct gccgagttta tcaaattcac ggtcattagg taagtgagag tttcctgctt   3120

agtcacagga gcgaatctgg agctcatgag gctgactctt ctaaaatgca gccacaggta   3180

gtcatcgaat ccggcttcct atgctgtgca atcaacaaat caaaataact tgtgtcatca   3240

ttagaatgtc agatgtgctt ctacgaacta agctgactct tttaattctt tggcaaaggg   3300

ttggcaaact aggactgttt gccaaattca ggctgcctcc tatttttaga gtcttcctga   3360

aacacagcta cacccgtatt atccatggct gctttcctgt cacagtgagt aagtagctgg   3420

gactgagaag gcatggcctc caaagtctaa aatatttact ctctagcact ttgtagaaaa   3480

accttagcta ggcacagtgg ctaacgcctg taatcccagc attttgggag gccaaggcag   3540

gcagatcacc tgaggtcagg agttccagac cagcctggcc aacatggtga aatcccatct   3600

ctacaaaaat aaaacagtta gctgggcatg atggcgggtg cctgtaatcc cagctactcg   3660

ggaggctgag gcaggatagt cgcttgaacc caggaggtgg aggttgcaat gagccaagat   3720

catgccactg cactccagcc tggacgacag agtgagactc catcacaaga aaaaaagaac   3780

tttgtcaacc tctgtcttag ggcgccttgt cacaggcttc gggtcagacg gattcaacct   3840

tgcatcagcc atttgttagc caggtcactc tgttctttgt ctgtaaatga gattgatcgt   3900

tgttcccact gagagtgtca gctccttccc gtagagcagg catgatgatt gtactcacct   3960

ctgacaccat tgtgagtgcc acattccttc ccacgtcctt gtcactgtaa gagatgccca   4020

cctgagcacc aaccccaggt tatcttcccc tttgtcttcc agccccccag aaacagctac   4080

gactcaacct acccaatcat ttcatcatca gattgccact gtctctagtt caggtctctt   4140

gggactggca ctcagaaatc tcataataaa tcctcttgag gcttctcata cactcgtctt   4200

cttccaatct tctttccctc aaaatctcat attttggttc cacttcaccc accgtcattc   4260

tccatatcac tcccaggagt taggcaaaaa gccccttccg ttcttccgta tgttaaactt   4320

agaatcactc tgttccctgc tctgcgtttc tattttttgt ttttcctcca tttactagta   4380

gcttaacact ttctaacagt gttcttatta ttgatacgta tctatctctt ccataagctt   4440

ataaggtcac ggataatact tctcattgta gtacgtaaat gacgtgggct agatatgagt   4500

tgaataaaca gttatacctg taaattctta cagagtgaaa ataaattgtt atactttaca   4560

atttgtttct ctctttagac catttccagg acttgtgatt aataaccgtg agtattttgt   4620

gaagtgtttt gtttttgttt tttcctgggg tctgacgtgt gtgcgtgtga gtgtgtatac   4680

atgcttaacg tatatcacgt tacttcacct atgtcagtaa ccaggccaaa tacttgtttt   4740

agccctcagt aaaaacacca ggcacttcct agttgtaaaa ttattcaagc ttcttaactt   4800

cctatcctcg atgcacttaa tcataaaatg gtaataatag caccgatttt gggggagtcg   4860

ttccagtaga tggaaagcat ctggaacagg tgtcagcaag ctcctgccga cgtgtatgca   4920

taaagtttta ttgaaaccac catcgtgtcc atttgtttat ggcagaactg agagatggca   4980

gcagcaagtg tgtgcctgca aaacctaaaa tatttactaa ttggctctgc aagaaaagag   5040

tttgcatccc cctaacctag aacagtgtct agcctctagt atgtgtttag cctacagtat   5100

gtgctcagcg aatacaatct atatttatta ctgcttttat gactgttata attactgtgc   5160

ttggatttcg ttacaaagta agtcacaatg tgcctgcttc tgttagtatt tcagcacagt   5220

gcctggcaca catggggctc tcaaatattg ctgagcgagt gaacaaatgt cctttcaatt   5280

ccttaacgtt gatgtcattt tcaatagtat tttgagccaa acttaatttt gcgagtgtgt   5340

tttgttttct taactttatt attaaaaatg tataaaagtg aggccaggcg tggtggctca   5400

cgcctgtaat cccagcagtt tgggaggctg aggcaggcgg atcagttgag gttgggagtt   5460

ggagaccagc ccgtccaaca tggtgaaagc ctgtctctac taaaaataca aaaatcagct   5520

gggtgtggtg gcgcgtgcct gtaatcccag ctactcagga ggctgaggca ggagagttgc   5580

ttgaatccta gaggtggagg ttgcagtgag ctgagatcgt gccattgcac tccagcctgg   5640

gcaacaagag caaaactctg tcccaataaa taaataaata aaatgttctc ttttgttcct   5700

gttcttgtgc ggtagtgtgg tatagagttt tatggtaatt actgtgaatt agtgattctg   5760

agggacatat cagaactctg aggtttgttt ccttctcatc ttgagggaaa cagcaaatgt   5820

atgttaaaat gcttttccaa gggaacaaca catccttaca ttatttaaac caatctgctt   5880

cattttcaga gctggttgat cagagtgagt cagaaggccc cgtgatacaa gaatcagctg   5940

aaccaagcca gttggaagtt ccagccacag aagaaataaa agagactgat ggaagctctc   6000

agatcaagca agaaccagac cccacgtggt agacctcttc cctcctaggc ttaaagtatc   6060

agtggttgag aagagctttt cggacctgtt actaccccaa gctgtgtaat atacttgtat   6120

aacagaaata ccttctatac aaaccttttt ttctactttt agatagaaat gtctactttt   6180

tcagcagttc tgtgaattaa agagcagagt gactgtgggt ctggaatggc tggtgtactt   6240

gggaatgtac tatcaggatt ttacagcaat gctgggaaat gacagggaaa atgacaggaa   6300

tgaatctcac cagatttttt atgtactcag cagagccttg agttacggtg tttattttcc   6360

aatcaagtga agatatctcc tacttctcct actggaacat ctcagcttct gcagtgaaga   6420

aaaattcctg tgatagttca gttctttagt ttttctattt gaaaaaaaaa aatcatttaa   6480

atgatccttt gttcacggct ctccttaatg actgagtgaa cagttcctat ctgtatattt   6540

gactaaacct tttcctaagc tatctctcat ggttcctatg tttttttatc ataattaaaa   6600

gcaaaaccat ctggatcacc taacagtcag aggtcagtat ctcagcgtgt gaattataga   6660

ggaaatacag agagaacctc ttccactttt acttttcgtc caaataaaat gcatggtgta   6720

ccagaagttg aagatcgggt tgaggattgg ggctagctcg atgacactaa ggccccaaca   6780

tcgcgggacc tgctgtggcg cggattctta ggaacgctgt tctagccggc cccctctcca   6840

ggggtcgccg tggccggcat tatttcctag ttcttcttgt aaccctgagg tgccagcgcg   6900

gggagtgagg aggggtcagg gggctaagga tgcaacctct gacgttctgc gccttcctag   6960

gagagtctta catgtgttga gatttcacaa gcaatgcgag ttgtaaaata ccagctctac   7020

aagaagctag gctctgtgac ggcatagttt tcagtagctt tatcacaata ttcacaatgg   7080

agaattatat gacatggtag cagaaatagg cccttttatg tgttgcttct attttacctc   7140

aaattgtaga tatagggtaa tcaataaaat ccatccatgc ctttcacaca ctaagt       7196


<210>  4881
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  4881

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala 
            580                 585                 590


Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600                 605


<210>  4882
<211>  7131
<212>  DNA
<213>  Homo sapiens

<400>  4882
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagc tcaagctctt ggactcaccg   1980

aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag   2040

gcttgccaga ggggattccc ttccgaagcc ctacctggtt tggaattcca cgacttgaaa   2100

ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt   2160

cctacttgcc tcctgggatg gctagtaaaa taaacactaa agctttgcag tcccccaaaa   2220

gaccacgaag tcctgggagt aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc   2280

ctaataacaa caatcctcaa acctcagctg ttcgaacccc gacccagact aacggttcta   2340

acgttccctt caagccacga gggagagagt tttcctttga ggcctggaat gccaaaatca   2400

cggacctaaa acagaaagtt gaaaatctct tcaatgagaa atgtggggaa gctcttggcc   2460

ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc tttcccggaa gacttttatg   2520

tggaaggctt acctgagggt gtgccattcc gaagaccatc gacttttggc attccgaggc   2580

tggagaagat actcagaaac aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt   2640

ttgagacggc gattaaggag agcacctcct ctaagagccc tcccagaaaa ataaattcat   2700

cacccaatgt taatactact gcatcaggtg ttgaagacct taacatcatt caggtgacaa   2760

ttccagatga tgataatgaa agactctcga aagttgaaaa agctagacag ctaagagaac   2820

aagtgaatga cctctttagt cggaaatttg gtgaagctat tggtatgggt tttcctgtga   2880

aagttcccta caggaaaatc acaattaacc ctggctgtgt ggtggttgat ggcatgcccc   2940

cgggggtgtc cttcaaagcc cccagctacc tggaaatcag ctccatgaga aggatcttag   3000

actctgccga gtttatcaaa ttcacggtca ttaggtaagt gagagtttcc tgcttagtca   3060

caggagcgaa tctggagctc atgaggctga ctcttctaaa atgcagccac aggtagtcat   3120

cgaatccggc ttcctatgct gtgcaatcaa caaatcaaaa taacttgtgt catcattaga   3180

atgtcagatg tgcttctacg aactaagctg actcttttaa ttctttggca aagggttggc   3240

aaactaggac tgtttgccaa attcaggctg cctcctattt ttagagtctt cctgaaacac   3300

agctacaccc gtattatcca tggctgcttt cctgtcacag tgagtaagta gctgggactg   3360

agaaggcatg gcctccaaag tctaaaatat ttactctcta gcactttgta gaaaaacctt   3420

agctaggcac agtggctaac gcctgtaatc ccagcatttt gggaggccaa ggcaggcaga   3480

tcacctgagg tcaggagttc cagaccagcc tggccaacat ggtgaaatcc catctctaca   3540

aaaataaaac agttagctgg gcatgatggc gggtgcctgt aatcccagct actcgggagg   3600

ctgaggcagg atagtcgctt gaacccagga ggtggaggtt gcaatgagcc aagatcatgc   3660

cactgcactc cagcctggac gacagagtga gactccatca caagaaaaaa agaactttgt   3720

caacctctgt cttagggcgc cttgtcacag gcttcgggtc agacggattc aaccttgcat   3780

cagccatttg ttagccaggt cactctgttc tttgtctgta aatgagattg atcgttgttc   3840

ccactgagag tgtcagctcc ttcccgtaga gcaggcatga tgattgtact cacctctgac   3900

accattgtga gtgccacatt ccttcccacg tccttgtcac tgtaagagat gcccacctga   3960

gcaccaaccc caggttatct tcccctttgt cttccagccc cccagaaaca gctacgactc   4020

aacctaccca atcatttcat catcagattg ccactgtctc tagttcaggt ctcttgggac   4080

tggcactcag aaatctcata ataaatcctc ttgaggcttc tcatacactc gtcttcttcc   4140

aatcttcttt ccctcaaaat ctcatatttt ggttccactt cacccaccgt cattctccat   4200

atcactccca ggagttaggc aaaaagcccc ttccgttctt ccgtatgtta aacttagaat   4260

cactctgttc cctgctctgc gtttctattt tttgtttttc ctccatttac tagtagctta   4320

acactttcta acagtgttct tattattgat acgtatctat ctcttccata agcttataag   4380

gtcacggata atacttctca ttgtagtacg taaatgacgt gggctagata tgagttgaat   4440

aaacagttat acctgtaaat tcttacagag tgaaaataaa ttgttatact ttacaatttg   4500

tttctctctt tagaccattt ccaggacttg tgattaataa ccgtgagtat tttgtgaagt   4560

gttttgtttt tgttttttcc tggggtctga cgtgtgtgcg tgtgagtgtg tatacatgct   4620

taacgtatat cacgttactt cacctatgtc agtaaccagg ccaaatactt gttttagccc   4680

tcagtaaaaa caccaggcac ttcctagttg taaaattatt caagcttctt aacttcctat   4740

cctcgatgca cttaatcata aaatggtaat aatagcaccg attttggggg agtcgttcca   4800

gtagatggaa agcatctgga acaggtgtca gcaagctcct gccgacgtgt atgcataaag   4860

ttttattgaa accaccatcg tgtccatttg tttatggcag aactgagaga tggcagcagc   4920

aagtgtgtgc ctgcaaaacc taaaatattt actaattggc tctgcaagaa aagagtttgc   4980

atccccctaa cctagaacag tgtctagcct ctagtatgtg tttagcctac agtatgtgct   5040

cagcgaatac aatctatatt tattactgct tttatgactg ttataattac tgtgcttgga   5100

tttcgttaca aagtaagtca caatgtgcct gcttctgtta gtatttcagc acagtgcctg   5160

gcacacatgg ggctctcaaa tattgctgag cgagtgaaca aatgtccttt caattcctta   5220

acgttgatgt cattttcaat agtattttga gccaaactta attttgcgag tgtgttttgt   5280

tttcttaact ttattattaa aaatgtataa aagtgaggcc aggcgtggtg gctcacgcct   5340

gtaatcccag cagtttggga ggctgaggca ggcggatcag ttgaggttgg gagttggaga   5400

ccagcccgtc caacatggtg aaagcctgtc tctactaaaa atacaaaaat cagctgggtg   5460

tggtggcgcg tgcctgtaat cccagctact caggaggctg aggcaggaga gttgcttgaa   5520

tcctagaggt ggaggttgca gtgagctgag atcgtgccat tgcactccag cctgggcaac   5580

aagagcaaaa ctctgtccca ataaataaat aaataaaatg ttctcttttg ttcctgttct   5640

tgtgcggtag tgtggtatag agttttatgg taattactgt gaattagtga ttctgaggga   5700

catatcagaa ctctgaggtt tgtttccttc tcatcttgag ggaaacagca aatgtatgtt   5760

aaaatgcttt tccaagggaa caacacatcc ttacattatt taaaccaatc tgcttcattt   5820

tcagagctgg ttgatcagag tgagtcagaa ggccccgtga tacaagaatc agctgaacca   5880

agccagttgg aagttccagc cacagaagaa ataaaagaga ctgatggaag ctctcagatc   5940

aagcaagaac cagaccccac gtggtagacc tcttccctcc taggcttaaa gtatcagtgg   6000

ttgagaagag cttttcggac ctgttactac cccaagctgt gtaatatact tgtataacag   6060

aaataccttc tatacaaacc tttttttcta cttttagata gaaatgtcta ctttttcagc   6120

agttctgtga attaaagagc agagtgactg tgggtctgga atggctggtg tacttgggaa   6180

tgtactatca ggattttaca gcaatgctgg gaaatgacag ggaaaatgac aggaatgaat   6240

ctcaccagat tttttatgta ctcagcagag ccttgagtta cggtgtttat tttccaatca   6300

agtgaagata tctcctactt ctcctactgg aacatctcag cttctgcagt gaagaaaaat   6360

tcctgtgata gttcagttct ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat   6420

cctttgttca cggctctcct taatgactga gtgaacagtt cctatctgta tatttgacta   6480

aaccttttcc taagctatct ctcatggttc ctatgttttt ttatcataat taaaagcaaa   6540

accatctgga tcacctaaca gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa   6600

tacagagaga acctcttcca cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga   6660

agttgaagat cgggttgagg attggggcta gctcgatgac actaaggccc caacatcgcg   6720

ggacctgctg tggcgcggat tcttaggaac gctgttctag ccggccccct ctccaggggt   6780

cgccgtggcc ggcattattt cctagttctt cttgtaaccc tgaggtgcca gcgcggggag   6840

tgaggagggg tcagggggct aaggatgcaa cctctgacgt tctgcgcctt cctaggagag   6900

tcttacatgt gttgagattt cacaagcaat gcgagttgta aaataccagc tctacaagaa   6960

gctaggctct gtgacggcat agttttcagt agctttatca caatattcac aatggagaat   7020

tatatgacat ggtagcagaa ataggccctt ttatgtgttg cttctatttt acctcaaatt   7080

gtagatatag ggtaatcaat aaaatccatc catgcctttc acacactaag t            7131


<210>  4883
<211>  878
<212>  PRT
<213>  Homo sapiens

<400>  4883

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala 
        515                 520                 525


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr 
    530                 535                 540


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe 
545                 550                 555                 560


Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys 
                565                 570                 575


Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly 
            580                 585                 590


Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro 
        595                 600                 605


Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val 
    610                 615                 620


Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro 
625                 630                 635                 640


Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu 
                645                 650                 655


Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys 
            660                 665                 670


Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys 
        675                 680                 685


Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp 
    690                 695                 700


Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser 
705                 710                 715                 720


Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys 
                725                 730                 735


Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys 
            740                 745                 750


Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro 
        755                 760                 765


Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln 
    770                 775                 780


Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys 
785                 790                 795                 800


Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe 
                805                 810                 815


Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys 
            820                 825                 830


Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly 
        835                 840                 845


Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg 
    850                 855                 860


Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
865                 870                 875


<210>  4884
<211>  5091
<212>  DNA
<213>  Homo sapiens

<400>  4884
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagc   2040

tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc   2100

ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc ctacctggtt   2160

tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa   2220

aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa taaacactaa   2280

agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg ttcctgaaat   2340

tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg ttcgaacccc   2400

gacccagact aacggttcta acgttccctt caagccacga gggagagagt tttcctttga   2460

ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct tcaatgagaa   2520

atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc   2580

tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc gaagaccatc   2640

gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa ttaagttcat   2700

cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct ctaagagccc   2760

tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg ttgaagacct   2820

taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga aagttgaaaa   2880

agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg gtgaagctat   2940

tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc ctggctgtgt   3000

ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc tggaaatcag   3060

ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca ttagaccatt   3120

tccaggactt gtgattaata accagctggt tgatcagagt gagtcagaag gccccgtgat   3180

acaagaatca gctgaaccaa gccagttgga agttccagcc acagaaggta aaaggacctc   3240

ttccctccta gggtaaatca gcttctgtgt cagggatgct gtgtggtgtc catctgaacc   3300

ccctgcatac gcgtagctaa tgtgatctcc ccactttcac ataagatggt ggccctgcct   3360

tcagggaatg tgggagccag gtgggagcct tcccggatat ttaagctaga agattctaca   3420

gggagattct ccttggatca atatatgtct ctcagtcaaa gatgtaaaag cacttttgcc   3480

ttaaaaagaa tgttctgttt ctaaatagag tcaacgttgt cctcctcatt ggaattcact   3540

atgagtcaga atcattagac tgactttttt ttttccatag taatagtatt ttgcagagtc   3600

tcacagagct gcagatcttt tgttcatctt gcagagttaa caagtctgat cctgttagtc   3660

cagatttctt aaatttggcc aagttataat aggagcagta gcttgagacc cgaagtcagg   3720

aaactttgac aatggatttt tttttttaat ccagagactt gtactggaat ttgccttacc   3780

ctgtcagctc atggacttaa ggtttcatcc cgctttatga gtgcttctga atccaagtca   3840

ttgttacctg aatttgcaaa ttaagttgtg atattcgtga ctgttaaatt cctgtaatta   3900

gattaacctc tttgcttgct tgtttgtttt ctctcctatt ttagcttaaa gtatcagtgg   3960

ttgagaagag cttttcggac ctgttactac cccaagctgt gtaatatact tgtataacag   4020

aaataccttc tatacaaacc tttttttcta cttttagata gaaatgtcta ctttttcagc   4080

agttctgtga attaaagagc agagtgactg tgggtctgga atggctggtg tacttgggaa   4140

tgtactatca ggattttaca gcaatgctgg gaaatgacag ggaaaatgac aggaatgaat   4200

ctcaccagat tttttatgta ctcagcagag ccttgagtta cggtgtttat tttccaatca   4260

agtgaagata tctcctactt ctcctactgg aacatctcag cttctgcagt gaagaaaaat   4320

tcctgtgata gttcagttct ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat   4380

cctttgttca cggctctcct taatgactga gtgaacagtt cctatctgta tatttgacta   4440

aaccttttcc taagctatct ctcatggttc ctatgttttt ttatcataat taaaagcaaa   4500

accatctgga tcacctaaca gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa   4560

tacagagaga acctcttcca cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga   4620

agttgaagat cgggttgagg attggggcta gctcgatgac actaaggccc caacatcgcg   4680

ggacctgctg tggcgcggat tcttaggaac gctgttctag ccggccccct ctccaggggt   4740

cgccgtggcc ggcattattt cctagttctt cttgtaaccc tgaggtgcca gcgcggggag   4800

tgaggagggg tcagggggct aaggatgcaa cctctgacgt tctgcgcctt cctaggagag   4860

tcttacatgt gttgagattt cacaagcaat gcgagttgta aaataccagc tctacaagaa   4920

gctaggctct gtgacggcat agttttcagt agctttatca caatattcac aatggagaat   4980

tatatgacat ggtagcagaa ataggccctt ttatgtgttg cttctatttt acctcaaatt   5040

gtagatatag ggtaatcaat aaaatccatc catgcctttc acacactaag t            5091


<210>  4885
<211>  944
<212>  PRT
<213>  Homo sapiens

<400>  4885

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly 
    530                 535                 540


Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro 
545                 550                 555                 560


Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser 
                565                 570                 575


Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser 
            580                 585                 590


Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr 
        595                 600                 605


Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser 
    610                 615                 620


Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile 
625                 630                 635                 640


Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala 
                645                 650                 655


Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro 
            660                 665                 670


Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp 
        675                 680                 685


Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala 
    690                 695                 700


Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser 
705                 710                 715                 720


Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe 
                725                 730                 735


Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg 
            740                 745                 750


Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu 
        755                 760                 765


Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile 
    770                 775                 780


Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu 
785                 790                 795                 800


Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser 
                805                 810                 815


Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe 
            820                 825                 830


Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val 
        835                 840                 845


Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly 
    850                 855                 860


Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser 
865                 870                 875                 880


Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val 
                885                 890                 895


Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln 
            900                 905                 910


Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln 
        915                 920                 925


Leu Glu Val Pro Ala Thr Glu Gly Lys Arg Thr Ser Ser Leu Leu Gly 
    930                 935                 940


<210>  4886
<211>  8084
<212>  DNA
<213>  Homo sapiens

<400>  4886
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   2040

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2100

gaaatttgct tagatttgtt gacagcggtt tcctggagtg ctgtcttgag aacgattctg   2160

aggaggctca gcaagaaaga gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa   2220

ctcaagctct tggactcacc gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc   2280

cggagttctt gtatgtggaa ggcttgccag aggggattcc cttccgaagc cctacctggt   2340

ttggaattcc acgacttgaa aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta   2400

aaaaacctga actagttatt tcctacttgc ctcctgggat ggctagtaaa ataaacacta   2460

aagctttgca gtcccccaaa agaccacgaa gtcctgggag taattcaaag gttcctgaaa   2520

ttgaggtcac cgtggaaggc cctaataaca acaatcctca aacctcagct gttcgaaccc   2580

cgacccagac taacggttct aacgttccct tcaagccacg agggagagag ttttcctttg   2640

aggcctggaa tgccaaaatc acggacctaa aacagaaagt tgaaaatctc ttcaatgaga   2700

aatgtgggga agctcttggc cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt   2760

ctttcccgga agacttttat gtggaaggct tacctgaggg tgtgccattc cgaagaccat   2820

cgacttttgg cattccgagg ctggagaaga tactcagaaa caaagccaaa attaagttca   2880

tcattaaaaa gcccgaaatg tttgagacgg cgattaagga gagcacctcc tctaagagcc   2940

ctcccagaaa aataaattca tcacccaatg ttaatactac tgcatcaggt gttgaagacc   3000

ttaacatcat tcaggtgaca attccagatg atgataatga aagactctcg aaagttgaaa   3060

aagctagaca gctaagagaa caagtgaatg acctctttag tcggaaattt ggtgaagcta   3120

ttggtatggg ttttcctgtg aaagttccct acaggaaaat cacaattaac cctggctgtg   3180

tggtggttga tggcatgccc ccgggggtgt ccttcaaagc ccccagctac ctggaaatca   3240

gctccatgag aaggatctta gactctgccg agtttatcaa attcacggtc attaggtaag   3300

tgagagtttc ctgcttagtc acaggagcga atctggagct catgaggctg actcttctaa   3360

aatgcagcca caggtagtca tcgaatccgg cttcctatgc tgtgcaatca acaaatcaaa   3420

ataacttgtg tcatcattag aatgtcagat gtgcttctac gaactaagct gactctttta   3480

attctttggc aaagggttgg caaactagga ctgtttgcca aattcaggct gcctcctatt   3540

tttagagtct tcctgaaaca cagctacacc cgtattatcc atggctgctt tcctgtcaca   3600

gtgagtaagt agctgggact gagaaggcat ggcctccaaa gtctaaaata tttactctct   3660

agcactttgt agaaaaacct tagctaggca cagtggctaa cgcctgtaat cccagcattt   3720

tgggaggcca aggcaggcag atcacctgag gtcaggagtt ccagaccagc ctggccaaca   3780

tggtgaaatc ccatctctac aaaaataaaa cagttagctg ggcatgatgg cgggtgcctg   3840

taatcccagc tactcgggag gctgaggcag gatagtcgct tgaacccagg aggtggaggt   3900

tgcaatgagc caagatcatg ccactgcact ccagcctgga cgacagagtg agactccatc   3960

acaagaaaaa aagaactttg tcaacctctg tcttagggcg ccttgtcaca ggcttcgggt   4020

cagacggatt caaccttgca tcagccattt gttagccagg tcactctgtt ctttgtctgt   4080

aaatgagatt gatcgttgtt cccactgaga gtgtcagctc cttcccgtag agcaggcatg   4140

atgattgtac tcacctctga caccattgtg agtgccacat tccttcccac gtccttgtca   4200

ctgtaagaga tgcccacctg agcaccaacc ccaggttatc ttcccctttg tcttccagcc   4260

ccccagaaac agctacgact caacctaccc aatcatttca tcatcagatt gccactgtct   4320

ctagttcagg tctcttggga ctggcactca gaaatctcat aataaatcct cttgaggctt   4380

ctcatacact cgtcttcttc caatcttctt tccctcaaaa tctcatattt tggttccact   4440

tcacccaccg tcattctcca tatcactccc aggagttagg caaaaagccc cttccgttct   4500

tccgtatgtt aaacttagaa tcactctgtt ccctgctctg cgtttctatt ttttgttttt   4560

cctccattta ctagtagctt aacactttct aacagtgttc ttattattga tacgtatcta   4620

tctcttccat aagcttataa ggtcacggat aatacttctc attgtagtac gtaaatgacg   4680

tgggctagat atgagttgaa taaacagtta tacctgtaaa ttcttacaga gtgaaaataa   4740

attgttatac tttacaattt gtttctctct ttagaccatt tccaggactt gtgattaata   4800

accgtgagta ttttgtgaag tgttttgttt ttgttttttc ctggggtctg acgtgtgtgc   4860

gtgtgagtgt gtatacatgc ttaacgtata tcacgttact tcacctatgt cagtaaccag   4920

gccaaatact tgttttagcc ctcagtaaaa acaccaggca cttcctagtt gtaaaattat   4980

tcaagcttct taacttccta tcctcgatgc acttaatcat aaaatggtaa taatagcacc   5040

gattttgggg gagtcgttcc agtagatgga aagcatctgg aacaggtgtc agcaagctcc   5100

tgccgacgtg tatgcataaa gttttattga aaccaccatc gtgtccattt gtttatggca   5160

gaactgagag atggcagcag caagtgtgtg cctgcaaaac ctaaaatatt tactaattgg   5220

ctctgcaaga aaagagtttg catcccccta acctagaaca gtgtctagcc tctagtatgt   5280

gtttagccta cagtatgtgc tcagcgaata caatctatat ttattactgc ttttatgact   5340

gttataatta ctgtgcttgg atttcgttac aaagtaagtc acaatgtgcc tgcttctgtt   5400

agtatttcag cacagtgcct ggcacacatg gggctctcaa atattgctga gcgagtgaac   5460

aaatgtcctt tcaattcctt aacgttgatg tcattttcaa tagtattttg agccaaactt   5520

aattttgcga gtgtgttttg ttttcttaac tttattatta aaaatgtata aaagtgaggc   5580

caggcgtggt ggctcacgcc tgtaatccca gcagtttggg aggctgaggc aggcggatca   5640

gttgaggttg ggagttggag accagcccgt ccaacatggt gaaagcctgt ctctactaaa   5700

aatacaaaaa tcagctgggt gtggtggcgc gtgcctgtaa tcccagctac tcaggaggct   5760

gaggcaggag agttgcttga atcctagagg tggaggttgc agtgagctga gatcgtgcca   5820

ttgcactcca gcctgggcaa caagagcaaa actctgtccc aataaataaa taaataaaat   5880

gttctctttt gttcctgttc ttgtgcggta gtgtggtata gagttttatg gtaattactg   5940

tgaattagtg attctgaggg acatatcaga actctgaggt ttgtttcctt ctcatcttga   6000

gggaaacagc aaatgtatgt taaaatgctt ttccaaggga acaacacatc cttacattat   6060

ttaaaccaat ctgcttcatt ttcagagctg gttgatcaga gtgagtcaga aggccccgtg   6120

atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag   6180

actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc   6240

ctagggtaaa tcagcttctg tgtcagggat gctgtgtggt gtccatctga accccctgca   6300

tacgcgtagc taatgtgatc tccccacttt cacataagat ggtggccctg ccttcaggga   6360

atgtgggagc caggtgggag ccttcccgga tatttaagct agaagattct acagggagat   6420

tctccttgga tcaatatatg tctctcagtc aaagatgtaa aagcactttt gccttaaaaa   6480

gaatgttctg tttctaaata gagtcaacgt tgtcctcctc attggaattc actatgagtc   6540

agaatcatta gactgacttt tttttttcca tagtaatagt attttgcaga gtctcacaga   6600

gctgcagatc ttttgttcat cttgcagagt taacaagtct gatcctgtta gtccagattt   6660

cttaaatttg gccaagttat aataggagca gtagcttgag acccgaagtc aggaaacttt   6720

gacaatggat tttttttttt aatccagaga cttgtactgg aatttgcctt accctgtcag   6780

ctcatggact taaggtttca tcccgcttta tgagtgcttc tgaatccaag tcattgttac   6840

ctgaatttgc aaattaagtt gtgatattcg tgactgttaa attcctgtaa ttagattaac   6900

ctctttgctt gcttgtttgt tttctctcct attttagctt aaagtatcag tggttgagaa   6960

gagcttttcg gacctgttac taccccaagc tgtgtaatat acttgtataa cagaaatacc   7020

ttctatacaa accttttttt ctacttttag atagaaatgt ctactttttc agcagttctg   7080

tgaattaaag agcagagtga ctgtgggtct ggaatggctg gtgtacttgg gaatgtacta   7140

tcaggatttt acagcaatgc tgggaaatga cagggaaaat gacaggaatg aatctcacca   7200

gattttttat gtactcagca gagccttgag ttacggtgtt tattttccaa tcaagtgaag   7260

atatctccta cttctcctac tggaacatct cagcttctgc agtgaagaaa aattcctgtg   7320

atagttcagt tctttagttt ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt   7380

tcacggctct ccttaatgac tgagtgaaca gttcctatct gtatatttga ctaaaccttt   7440

tcctaagcta tctctcatgg ttcctatgtt tttttatcat aattaaaagc aaaaccatct   7500

ggatcaccta acagtcagag gtcagtatct cagcgtgtga attatagagg aaatacagag   7560

agaacctctt ccacttttac ttttcgtcca aataaaatgc atggtgtacc agaagttgaa   7620

gatcgggttg aggattgggg ctagctcgat gacactaagg ccccaacatc gcgggacctg   7680

ctgtggcgcg gattcttagg aacgctgttc tagccggccc cctctccagg ggtcgccgtg   7740

gccggcatta tttcctagtt cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag   7800

gggtcagggg gctaaggatg caacctctga cgttctgcgc cttcctagga gagtcttaca   7860

tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc agctctacaa gaagctaggc   7920

tctgtgacgg catagttttc agtagcttta tcacaatatt cacaatggag aattatatga   7980

catggtagca gaaataggcc cttttatgtg ttgcttctat tttacctcaa attgtagata   8040

tagggtaatc aataaaatcc atccatgcct ttcacacact aagt                    8084


<210>  4887
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  4887

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala 



<210>  4888
<211>  4387
<212>  DNA
<213>  Homo sapiens

<400>  4888
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagctca   1980

agctcttgga ctcaccgagg cagtaaaagt accatatcct gtgtttgaat caaacccgga   2040

gttcttgtat gtggaaggct tgccagaggg gattcccttc cgaagcccta cctggtttgg   2100

aattccacga cttgaaagga tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa   2160

acctgaacta gttatttcct acttgcctcc tgggatggct agtaaaataa acactaaagc   2220

tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga   2280

ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc tcagctgttc gaaccccgac   2340

ccagactaac ggttctaacg ttcccttcaa gccacgaggg agagagtttt cctttgaggc   2400

ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa aatctcttca atgagaaatg   2460

tggggaagct cttggcctta aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt   2520

cccggaagac ttttatgtgg aaggcttacc tgagggtgtg ccattccgaa gaccatcgac   2580

ttttggcatt ccgaggctgg agaagatact cagaaacaaa gccaaaatta agttcatcat   2640

taaaaagccc gaaatgtttg agacggcgat taaggagagc acctcctcta agagccctcc   2700

cagaaaaata aattcatcac ccaatgttaa tactactgca tcaggtgttg aagaccttaa   2760

catcattcag gtgacaattc cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc   2820

tagacagcta agagaacaag tgaatgacct ctttagtcgg aaatttggtg aagctattgg   2880

tatgggtttt cctgtgaaag ttccctacag gaaaatcaca attaaccctg gctgtgtggt   2940

ggttgatggc atgcccccgg gggtgtcctt caaagccccc agctacctgg aaatcagctc   3000

catgagaagg atcttagact ctgccgagtt tatcaaattc acggtcatta gaccatttcc   3060

aggacttgtg attaataacc agctggttga tcagagtgag tcagaaggcc ccgtgataca   3120

agaatcagct gaaccaagcc agttggaagt tccagccaca gaagaaataa aagagactga   3180

tggaagctct cagatcaagc aagaaccaga ccccacgtgg tagacctctt ccctcctagg   3240

cttaaagtat cagtggttga gaagagcttt tcggacctgt tactacccca agctgtgtaa   3300

tatacttgta taacagaaat accttctata caaacctttt tttctacttt tagatagaaa   3360

tgtctacttt ttcagcagtt ctgtgaatta aagagcagag tgactgtggg tctggaatgg   3420

ctggtgtact tgggaatgta ctatcaggat tttacagcaa tgctgggaaa tgacagggaa   3480

aatgacagga atgaatctca ccagattttt tatgtactca gcagagcctt gagttacggt   3540

gtttattttc caatcaagtg aagatatctc ctacttctcc tactggaaca tctcagcttc   3600

tgcagtgaag aaaaattcct gtgatagttc agttctttag tttttctatt tgaaaaaaaa   3660

aaatcattta aatgatcctt tgttcacggc tctccttaat gactgagtga acagttccta   3720

tctgtatatt tgactaaacc ttttcctaag ctatctctca tggttcctat gtttttttat   3780

cataattaaa agcaaaacca tctggatcac ctaacagtca gaggtcagta tctcagcgtg   3840

tgaattatag aggaaataca gagagaacct cttccacttt tacttttcgt ccaaataaaa   3900

tgcatggtgt accagaagtt gaagatcggg ttgaggattg gggctagctc gatgacacta   3960

aggccccaac atcgcgggac ctgctgtggc gcggattctt aggaacgctg ttctagccgg   4020

ccccctctcc aggggtcgcc gtggccggca ttatttccta gttcttcttg taaccctgag   4080

gtgccagcgc ggggagtgag gaggggtcag ggggctaagg atgcaacctc tgacgttctg   4140

cgccttccta ggagagtctt acatgtgttg agatttcaca agcaatgcga gttgtaaaat   4200

accagctcta caagaagcta ggctctgtga cggcatagtt ttcagtagct ttatcacaat   4260

attcacaatg gagaattata tgacatggta gcagaaatag gcccttttat gtgttgcttc   4320

tattttacct caaattgtag atatagggta atcaataaaa tccatccatg cctttcacac   4380

actaagt                                                             4387


<210>  4889
<211>  933
<212>  PRT
<213>  Homo sapiens

<400>  4889

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
        515                 520                 525


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
    530                 535                 540


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
545                 550                 555                 560


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
                565                 570                 575


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
            580                 585                 590


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
        595                 600                 605


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
    610                 615                 620


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
625                 630                 635                 640


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
                645                 650                 655


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
            660                 665                 670


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
        675                 680                 685


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
    690                 695                 700


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
705                 710                 715                 720


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
                725                 730                 735


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
            740                 745                 750


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
        755                 760                 765


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
    770                 775                 780


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
785                 790                 795                 800


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
                805                 810                 815


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
            820                 825                 830


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
        835                 840                 845


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
    850                 855                 860


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro 
865                 870                 875                 880


Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly 
                885                 890                 895


Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala 
            900                 905                 910


Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu 
        915                 920                 925


Pro Asp Pro Thr Trp 
    930


<210>  4890
<211>  4571
<212>  DNA
<213>  Homo sapiens

<400>  4890
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   1980

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2040

gaaatttgct tagatttgtt gacagcggtt tcctggagtg ctgtcttgag aacgattctg   2100

aggaggctca gcaagaaaga gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa   2160

ctcaagctct tggactcacc gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc   2220

cggagttctt gtatgtggaa ggcttgccag aggggattcc cttccgaagc cctacctggt   2280

ttggaattcc acgacttgaa aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta   2340

aaaaacctga actagttatt tcctacttgc ctcctgggat ggctagtaaa ataaacacta   2400

aagctttgca gtcccccaaa agaccacgaa gtcctgggag taattcaaag gttcctgaaa   2460

ttgaggtcac cgtggaaggc cctaataaca acaatcctca aacctcagct gttcgaaccc   2520

cgacccagac taacggttct aacgttccct tcaagccacg agggagagag ttttcctttg   2580

aggcctggaa tgccaaaatc acggacctaa aacagaaagt tgaaaatctc ttcaatgaga   2640

aatgtgggga agctcttggc cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt   2700

ctttcccgga agacttttat gtggaaggct tacctgaggg tgtgccattc cgaagaccat   2760

cgacttttgg cattccgagg ctggagaaga tactcagaaa caaagccaaa attaagttca   2820

tcattaaaaa gcccgaaatg tttgagacgg cgattaagga gagcacctcc tctaagagcc   2880

ctcccagaaa aataaattca tcacccaatg ttaatactac tgcatcaggt gttgaagacc   2940

ttaacatcat tcaggtgaca attccagatg atgataatga aagactctcg aaagttgaaa   3000

aagctagaca gctaagagaa caagtgaatg acctctttag tcggaaattt ggtgaagcta   3060

ttggtatggg ttttcctgtg aaagttccct acaggaaaat cacaattaac cctggctgtg   3120

tggtggttga tggcatgccc ccgggggtgt ccttcaaagc ccccagctac ctggaaatca   3180

gctccatgag aaggatctta gactctgccg agtttatcaa attcacggtc attagaccat   3240

ttccaggact tgtgattaat aaccagctgg ttgatcagag tgagtcagaa ggccccgtga   3300

tacaagaatc agctgaacca agccagttgg aagttccagc cacagaagaa ataaaagaga   3360

ctgatggaag ctctcagatc aagcaagaac cagaccccac gtggtagacc tcttccctcc   3420

taggcttaaa gtatcagtgg ttgagaagag cttttcggac ctgttactac cccaagctgt   3480

gtaatatact tgtataacag aaataccttc tatacaaacc tttttttcta cttttagata   3540

gaaatgtcta ctttttcagc agttctgtga attaaagagc agagtgactg tgggtctgga   3600

atggctggtg tacttgggaa tgtactatca ggattttaca gcaatgctgg gaaatgacag   3660

ggaaaatgac aggaatgaat ctcaccagat tttttatgta ctcagcagag ccttgagtta   3720

cggtgtttat tttccaatca agtgaagata tctcctactt ctcctactgg aacatctcag   3780

cttctgcagt gaagaaaaat tcctgtgata gttcagttct ttagtttttc tatttgaaaa   3840

aaaaaaatca tttaaatgat cctttgttca cggctctcct taatgactga gtgaacagtt   3900

cctatctgta tatttgacta aaccttttcc taagctatct ctcatggttc ctatgttttt   3960

ttatcataat taaaagcaaa accatctgga tcacctaaca gtcagaggtc agtatctcag   4020

cgtgtgaatt atagaggaaa tacagagaga acctcttcca cttttacttt tcgtccaaat   4080

aaaatgcatg gtgtaccaga agttgaagat cgggttgagg attggggcta gctcgatgac   4140

actaaggccc caacatcgcg ggacctgctg tggcgcggat tcttaggaac gctgttctag   4200

ccggccccct ctccaggggt cgccgtggcc ggcattattt cctagttctt cttgtaaccc   4260

tgaggtgcca gcgcggggag tgaggagggg tcagggggct aaggatgcaa cctctgacgt   4320

tctgcgcctt cctaggagag tcttacatgt gttgagattt cacaagcaat gcgagttgta   4380

aaataccagc tctacaagaa gctaggctct gtgacggcat agttttcagt agctttatca   4440

caatattcac aatggagaat tatatgacat ggtagcagaa ataggccctt ttatgtgttg   4500

cttctatttt acctcaaatt gtagatatag ggtaatcaat aaaatccatc catgcctttc   4560

acacactaag t                                                        4571


<210>  4891
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  4891

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  4892
<211>  4040
<212>  DNA
<213>  Homo sapiens

<400>  4892
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagctc   1860

aagctcttgg actcaccgag gcagtaaaag taccatatcc tgtgtttgaa tcaaacccgg   1920

agttcttgta tgtggaaggc ttgccagagg ggattccctt ccgaagccct acctggtttg   1980

gaattccacg acttgaaagg atcgtccgcg ggagtaataa aatcaagttc gttgttaaaa   2040

aacctgaact agttatttcc tacttgcctc ctgggatggc tagtaaaata aacactaaag   2100

ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa ttcaaaggtt cctgaaattg   2160

aggtcaccgt ggaaggccct aataacaaca atcctcaaac ctcagctgtt cgaaccccga   2220

cccagactaa cggttctaac gttcccttca agccacgagg gagagagttt tcctttgagg   2280

cctggaatgc caaaatcacg gacctaaaac agaaagttga aaatctcttc aatgagaaat   2340

gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc gttcgcgtta tttgagtctt   2400

tcccggaaga cttttatgtg gaaggcttac ctgagggtgt gccattccga agaccatcga   2460

cttttggcat tccgaggctg gagaagatac tcagaaacaa agccaaaatt aagttcatca   2520

ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag cacctcctct aagagccctc   2580

ccagaaaaat aaattcatca cccaatgtta atactactgc atcaggtgtt gaagacctta   2640

acatcattca ggtgacaatt ccagatgatg ataatgaaag actctcgaaa gttgaaaaag   2700

ctagacagct aagagaacaa gtgaatgacc tctttagtcg gaaatttggt gaagctattg   2760

gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac aattaaccct ggctgtgtgg   2820

tggttgatgg catgcccccg ggggtgtcct tcaaagcccc cagctacctg gaaatcagct   2880

ccatgagaag gatcttagac tctgccgagt ttatcaaatt cacggtcatt agaccatttc   2940

caggacttgt gattaataac cagctggttg atcagagtga gtcagaaggc cccgtgatac   3000

aagaatcagc tgaaccaagc cagttggaag ttccagccac agaagaaata aaagagactg   3060

atggaagctc tcagatcaag caagaaccag accccacgtg gtagacctct tccctcctag   3120

gcttaaagta tcagtggttg agaagagctt ttcggacctg ttactacccc aagctgtagc   3180

cttgagttac ggtgtttatt ttccaatcaa gtgaagatat ctcctacttc tcctactgga   3240

acatctcagc ttctgcagtg aagaaaaatt cctgtgatag ttcagttctt tagtttttct   3300

atttgaaaaa aaaaaatcat ttaaatgatc ctttgttcac ggctctcctt aatgactgag   3360

tgaacagttc ctatctgtat atttgactaa accttttcct aagctatctc tcatggttcc   3420

tatgtttttt tatcataatt aaaagcaaaa ccatctggat cacctaacag tcagaggtca   3480

gtatctcagc gtgtgaatta tagaggaaat acagagagaa cctcttccac ttttactttt   3540

cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc gggttgagga ttggggctag   3600

ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg   3660

ctgttctagc cggccccctc tccaggggtc gccgtggccg gcattatttc ctagttcttc   3720

ttgtaaccct gaggtgccag cgcggggagt gaggaggggt cagggggcta aggatgcaac   3780

ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg ttgagatttc acaagcaatg   3840

cgagttgtaa aataccagct ctacaagaag ctaggctctg tgacggcata gttttcagta   3900

gctttatcac aatattcaca atggagaatt atatgacatg gtagcagaaa taggcccttt   3960

tatgtgttgc ttctatttta cctcaaattg tagatatagg gtaatcaata aaatccatcc   4020

atgcctttca cacactaagt                                               4040


<210>  4893
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  4893

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu 
            420                 425                 430


Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu 
        435                 440                 445


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp 
    450                 455                 460


Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile 
465                 470                 475                 480


Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro 
                485                 490                 495


Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg 
            500                 505                 510


Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr 
        515                 520                 525


Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr 
    530                 535                 540


Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg 
545                 550                 555                 560


Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln 
                565                 570                 575


Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu 
            580                 585                 590


Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu 
        595                 600                 605


Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro 
    610                 615                 620


Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala 
625                 630                 635                 640


Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile 
                645                 650                 655


Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser 
            660                 665                 670


Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile 
        675                 680                 685


Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu 
    690                 695                 700


Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys 
705                 710                 715                 720


Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg 
                725                 730                 735


Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro 
            740                 745                 750


Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg 
        755                 760                 765


Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro 
    770                 775                 780


Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser 
785                 790                 795                 800


Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val 
                805                 810                 815


Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys 
            820                 825                 830


Gln Glu Pro Asp Pro Thr Trp 
        835


<210>  4894
<211>  3895
<212>  DNA
<213>  Homo sapiens

<400>  4894
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1320

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1380

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1440

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1500

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1560

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1620

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1680

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1740

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1800

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1860

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1920

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1980

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagctca   2040

agctcttgga ctcaccgagg cagtaaaagt accatatcct gtgtttgaat caaacccgga   2100

gttcttgtat gtggaaggct tgccagaggg gattcccttc cgaagcccta cctggtttgg   2160

aattccacga cttgaaagga tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa   2220

acctgaacta gttatttcct acttgcctcc tgggatggct agtaaaataa acactaaagc   2280

tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga   2340

ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc tcagctgttc gaaccccgac   2400

ccagactaac ggttctaacg ttcccttcaa gccacgaggg agagagtttt cctttgaggc   2460

ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa aatctcttca atgagaaatg   2520

tggggaagct cttggcctta aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt   2580

cccggaagac ttttatgtgg aaggcttacc tgagggtgtg ccattccgaa gaccatcgac   2640

ttttggcatt ccgaggctgg agaagatact cagaaacaaa gccaaaatta agttcatcat   2700

taaaaagccc gaaatgtttg agacggcgat taaggagagc acctcctcta agagccctcc   2760

cagaaaaata aattcatcac ccaatgttaa tactactgca tcaggtgttg aagaccttaa   2820

catcattcag gtgacaattc cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc   2880

tagacagcta agagaacaag tgaatgacct ctttagtcgg aaatttggtg aagctattgg   2940

tatgggtttt cctgtgaaag ttccctacag gaaaatcaca attaaccctg gctgtgtggt   3000

ggttgatggc atgcccccgg gggtgtcctt caaagccccc agctacctgg aaatcagctc   3060

catgagaagg atcttagact ctgccgagtt tatcaaattc acggtcatta gaccatttcc   3120

aggacttgtg attaataacc agctggttga tcagagtgag tcagaaggcc ccgtgataca   3180

agaatcagct gaaccaagcc agttggaagt tccagccaca gaagaaataa aagagactga   3240

tggaagctct cagatcaagc aagaaccaga ccccacgtgg tagacctctt ccctcctagg   3300

caaaaccatc tggatcacct aacagtcaga ggtcagtatc tcagcgtgtg aattatagag   3360

gaaatacaga gagaacctct tccactttta cttttcgtcc aaataaaatg catggtgtac   3420

cagaagttga agatcgggtt gaggattggg gctagctcga tgacactaag gccccaacat   3480

cgcgggacct gctgtggcgc ggattcttag gaacgctgtt ctagccggcc ccctctccag   3540

gggtcgccgt ggccggcatt atttcctagt tcttcttgta accctgaggt gccagcgcgg   3600

ggagtgagga ggggtcaggg ggctaaggat gcaacctctg acgttctgcg ccttcctagg   3660

agagtcttac atgtgttgag atttcacaag caatgcgagt tgtaaaatac cagctctaca   3720

agaagctagg ctctgtgacg gcatagtttt cagtagcttt atcacaatat tcacaatgga   3780

gaattatatg acatggtagc agaaataggc ccttttatgt gttgcttcta ttttacctca   3840

aattgtagat atagggtaat caataaaatc catccatgcc tttcacacac taagt        3895


<210>  4895
<211>  953
<212>  PRT
<213>  Homo sapiens

<400>  4895

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu 
    530                 535                 540


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
545                 550                 555                 560


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
                565                 570                 575


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
            580                 585                 590


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
        595                 600                 605


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
    610                 615                 620


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
625                 630                 635                 640


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
                645                 650                 655


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
            660                 665                 670


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
        675                 680                 685


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
    690                 695                 700


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
705                 710                 715                 720


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
                725                 730                 735


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
            740                 745                 750


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
        755                 760                 765


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
    770                 775                 780


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
785                 790                 795                 800


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
                805                 810                 815


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
            820                 825                 830


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
        835                 840                 845


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
    850                 855                 860


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
865                 870                 875                 880


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
                885                 890                 895


Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser 
            900                 905                 910


Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu 
        915                 920                 925


Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln 
    930                 935                 940


Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  4896
<211>  7808
<212>  DNA
<213>  Homo sapiens

<400>  4896
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1980

catatcctgt gtttgaatca aacccggagt tcttgtatgt ggaaggcttg ccagagggga   2040

ttcccttccg aagccctacc tggtttggaa ttccacgact tgaaaggatc gtccgcggga   2100

gtaataaaat caagttcgtt gttaaaaaac ctgaactagt tatttcctac ttgcctcctg   2160

ggatggctag taaaataaac actaaagctt tgcagtcccc caaaagacca cgaagtcctg   2220

ggagtaattc aaaggttcct gaaattgagg tcaccgtgga aggccctaat aacaacaatc   2280

ctcaaacctc agctgttcga accccgaccc agactaacgg ttctaacgtt cccttcaagc   2340

cacgagggag agagttttcc tttgaggcct ggaatgccaa aatcacggac ctaaaacaga   2400

aagttgaaaa tctcttcaat gagaaatgtg gggaagctct tggccttaaa caagctgtga   2460

aggtgccgtt cgcgttattt gagtctttcc cggaagactt ttatgtggaa ggcttacctg   2520

agggtgtgcc attccgaaga ccatcgactt ttggcattcc gaggctggag aagatactca   2580

gaaacaaagc caaaattaag ttcatcatta aaaagcccga aatgtttgag acggcgatta   2640

aggagagcac ctcctctaag agccctccca gaaaaataaa ttcatcaccc aatgttaata   2700

ctactgcatc aggtgttgaa gaccttaaca tcattcaggt gacaattcca gatgatgata   2760

atgaaagact ctcgaaagtt gaaaaagcta gacagctaag agaacaagtg aatgacctct   2820

ttagtcggaa atttggtgaa gctattggta tgggttttcc tgtgaaagtt ccctacagga   2880

aaatcacaat taaccctggc tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca   2940

aagcccccag ctacctggaa atcagctcca tgagaaggat cttagactct gccgagttta   3000

tcaaattcac ggtcattagg taagtgagag tttcctgctt agtcacagga gcgaatctgg   3060

agctcatgag gctgactctt ctaaaatgca gccacaggta gtcatcgaat ccggcttcct   3120

atgctgtgca atcaacaaat caaaataact tgtgtcatca ttagaatgtc agatgtgctt   3180

ctacgaacta agctgactct tttaattctt tggcaaaggg ttggcaaact aggactgttt   3240

gccaaattca ggctgcctcc tatttttaga gtcttcctga aacacagcta cacccgtatt   3300

atccatggct gctttcctgt cacagtgagt aagtagctgg gactgagaag gcatggcctc   3360

caaagtctaa aatatttact ctctagcact ttgtagaaaa accttagcta ggcacagtgg   3420

ctaacgcctg taatcccagc attttgggag gccaaggcag gcagatcacc tgaggtcagg   3480

agttccagac cagcctggcc aacatggtga aatcccatct ctacaaaaat aaaacagtta   3540

gctgggcatg atggcgggtg cctgtaatcc cagctactcg ggaggctgag gcaggatagt   3600

cgcttgaacc caggaggtgg aggttgcaat gagccaagat catgccactg cactccagcc   3660

tggacgacag agtgagactc catcacaaga aaaaaagaac tttgtcaacc tctgtcttag   3720

ggcgccttgt cacaggcttc gggtcagacg gattcaacct tgcatcagcc atttgttagc   3780

caggtcactc tgttctttgt ctgtaaatga gattgatcgt tgttcccact gagagtgtca   3840

gctccttccc gtagagcagg catgatgatt gtactcacct ctgacaccat tgtgagtgcc   3900

acattccttc ccacgtcctt gtcactgtaa gagatgccca cctgagcacc aaccccaggt   3960

tatcttcccc tttgtcttcc agccccccag aaacagctac gactcaacct acccaatcat   4020

ttcatcatca gattgccact gtctctagtt caggtctctt gggactggca ctcagaaatc   4080

tcataataaa tcctcttgag gcttctcata cactcgtctt cttccaatct tctttccctc   4140

aaaatctcat attttggttc cacttcaccc accgtcattc tccatatcac tcccaggagt   4200

taggcaaaaa gccccttccg ttcttccgta tgttaaactt agaatcactc tgttccctgc   4260

tctgcgtttc tattttttgt ttttcctcca tttactagta gcttaacact ttctaacagt   4320

gttcttatta ttgatacgta tctatctctt ccataagctt ataaggtcac ggataatact   4380

tctcattgta gtacgtaaat gacgtgggct agatatgagt tgaataaaca gttatacctg   4440

taaattctta cagagtgaaa ataaattgtt atactttaca atttgtttct ctctttagac   4500

catttccagg acttgtgatt aataaccgtg agtattttgt gaagtgtttt gtttttgttt   4560

tttcctgggg tctgacgtgt gtgcgtgtga gtgtgtatac atgcttaacg tatatcacgt   4620

tacttcacct atgtcagtaa ccaggccaaa tacttgtttt agccctcagt aaaaacacca   4680

ggcacttcct agttgtaaaa ttattcaagc ttcttaactt cctatcctcg atgcacttaa   4740

tcataaaatg gtaataatag caccgatttt gggggagtcg ttccagtaga tggaaagcat   4800

ctggaacagg tgtcagcaag ctcctgccga cgtgtatgca taaagtttta ttgaaaccac   4860

catcgtgtcc atttgtttat ggcagaactg agagatggca gcagcaagtg tgtgcctgca   4920

aaacctaaaa tatttactaa ttggctctgc aagaaaagag tttgcatccc cctaacctag   4980

aacagtgtct agcctctagt atgtgtttag cctacagtat gtgctcagcg aatacaatct   5040

atatttatta ctgcttttat gactgttata attactgtgc ttggatttcg ttacaaagta   5100

agtcacaatg tgcctgcttc tgttagtatt tcagcacagt gcctggcaca catggggctc   5160

tcaaatattg ctgagcgagt gaacaaatgt cctttcaatt ccttaacgtt gatgtcattt   5220

tcaatagtat tttgagccaa acttaatttt gcgagtgtgt tttgttttct taactttatt   5280

attaaaaatg tataaaagtg aggccaggcg tggtggctca cgcctgtaat cccagcagtt   5340

tgggaggctg aggcaggcgg atcagttgag gttgggagtt ggagaccagc ccgtccaaca   5400

tggtgaaagc ctgtctctac taaaaataca aaaatcagct gggtgtggtg gcgcgtgcct   5460

gtaatcccag ctactcagga ggctgaggca ggagagttgc ttgaatccta gaggtggagg   5520

ttgcagtgag ctgagatcgt gccattgcac tccagcctgg gcaacaagag caaaactctg   5580

tcccaataaa taaataaata aaatgttctc ttttgttcct gttcttgtgc ggtagtgtgg   5640

tatagagttt tatggtaatt actgtgaatt agtgattctg agggacatat cagaactctg   5700

aggtttgttt ccttctcatc ttgagggaaa cagcaaatgt atgttaaaat gcttttccaa   5760

gggaacaaca catccttaca ttatttaaac caatctgctt cattttcaga gctggttgat   5820

cagagtgagt cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt   5880

ccagccacag aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac   5940

cccacgtggt agacctcttc cctcctaggg taaatcagct tctgtgtcag ggatgctgtg   6000

tggtgtccat ctgaaccccc tgcatacgcg tagctaatgt gatctcccca ctttcacata   6060

agatggtggc cctgccttca gggaatgtgg gagccaggtg ggagccttcc cggatattta   6120

agctagaaga ttctacaggg agattctcct tggatcaata tatgtctctc agtcaaagat   6180

gtaaaagcac ttttgcctta aaaagaatgt tctgtttcta aatagagtca acgttgtcct   6240

cctcattgga attcactatg agtcagaatc attagactga cttttttttt tccatagtaa   6300

tagtattttg cagagtctca cagagctgca gatcttttgt tcatcttgca gagttaacaa   6360

gtctgatcct gttagtccag atttcttaaa tttggccaag ttataatagg agcagtagct   6420

tgagacccga agtcaggaaa ctttgacaat ggattttttt ttttaatcca gagacttgta   6480

ctggaatttg ccttaccctg tcagctcatg gacttaaggt ttcatcccgc tttatgagtg   6540

cttctgaatc caagtcattg ttacctgaat ttgcaaatta agttgtgata ttcgtgactg   6600

ttaaattcct gtaattagat taacctcttt gcttgcttgt ttgttttctc tcctatttta   6660

gcttaaagta tcagtggttg agaagagctt ttcggacctg ttactacccc aagctgtgta   6720

atatacttgt ataacagaaa taccttctat acaaaccttt ttttctactt ttagatagaa   6780

atgtctactt tttcagcagt tctgtgaatt aaagagcaga gtgactgtgg gtctggaatg   6840

gctggtgtac ttgggaatgt actatcagga ttttacagca atgctgggaa atgacaggga   6900

aaatgacagg aatgaatctc accagatttt ttatgtactc agcagagcct tgagttacgg   6960

tgtttatttt ccaatcaagt gaagatatct cctacttctc ctactggaac atctcagctt   7020

ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa   7080

aaaatcattt aaatgatcct ttgttcacgg ctctccttaa tgactgagtg aacagttcct   7140

atctgtatat ttgactaaac cttttcctaa gctatctctc atggttccta tgttttttta   7200

tcataattaa aagcaaaacc atctggatca cctaacagtc agaggtcagt atctcagcgt   7260

gtgaattata gaggaaatac agagagaacc tcttccactt ttacttttcg tccaaataaa   7320

atgcatggtg taccagaagt tgaagatcgg gttgaggatt ggggctagct cgatgacact   7380

aaggccccaa catcgcggga cctgctgtgg cgcggattct taggaacgct gttctagccg   7440

gccccctctc caggggtcgc cgtggccggc attatttcct agttcttctt gtaaccctga   7500

ggtgccagcg cggggagtga ggaggggtca gggggctaag gatgcaacct ctgacgttct   7560

gcgccttcct aggagagtct tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa   7620

taccagctct acaagaagct aggctctgtg acggcatagt tttcagtagc tttatcacaa   7680

tattcacaat ggagaattat atgacatggt agcagaaata ggccctttta tgtgttgctt   7740

ctattttacc tcaaattgta gatatagggt aatcaataaa atccatccat gcctttcaca   7800

cactaagt                                                            7808


<210>  4897
<211>  812
<212>  PRT
<213>  Homo sapiens

<400>  4897

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
            420                 425                 430


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
        435                 440                 445


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
    450                 455                 460


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu 
465                 470                 475                 480


Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile 
                485                 490                 495


Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val 
            500                 505                 510


Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala 
        515                 520                 525


Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser 
    530                 535                 540


Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly 
545                 550                 555                 560


Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln 
                565                 570                 575


Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser 
            580                 585                 590


Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu 
        595                 600                 605


Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala 
    610                 615                 620


Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr 
625                 630                 635                 640


Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe 
                645                 650                 655


Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys 
            660                 665                 670


Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser 
        675                 680                 685


Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val 
    690                 695                 700


Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr 
705                 710                 715                 720


Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg 
                725                 730                 735


Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu 
            740                 745                 750


Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr 
        755                 760                 765


Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser 
    770                 775                 780


Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu 
785                 790                 795                 800


Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
                805                 810


<210>  4898
<211>  5098
<212>  DNA
<213>  Homo sapiens

<400>  4898
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1200

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1260

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1320

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1380

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1440

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1500

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1560

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1620

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1680

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1740

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1800

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1860

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1920

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1980

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   2040

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   2100

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2160

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2220

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2280

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2340

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2400

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2460

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2520

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2580

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2640

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2700

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2760

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2820

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2880

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2940

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   3000

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   3060

cggtcattag accatttcca ggacttgtga ttaataacca gctggttgat cagagtgagt   3120

cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt ccagccacag   3180

aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac cccacgtggt   3240

agacctcttc cctcctaggg taaatcagct tctgtgtcag ggatgctgtg tggtgtccat   3300

ctgaaccccc tgcatacgcg tagctaatgt gatctcccca ctttcacata agatggtggc   3360

cctgccttca gggaatgtgg gagccaggtg ggagccttcc cggatattta agctagaaga   3420

ttctacaggg agattctcct tggatcaata tatgtctctc agtcaaagat gtaaaagcac   3480

ttttgcctta aaaagaatgt tctgtttcta aatagagtca acgttgtcct cctcattgga   3540

attcactatg agtcagaatc attagactga cttttttttt tccatagtaa tagtattttg   3600

cagagtctca cagagctgca gatcttttgt tcatcttgca gagttaacaa gtctgatcct   3660

gttagtccag atttcttaaa tttggccaag ttataatagg agcagtagct tgagacccga   3720

agtcaggaaa ctttgacaat ggattttttt ttttaatcca gagacttgta ctggaatttg   3780

ccttaccctg tcagctcatg gacttaaggt ttcatcccgc tttatgagtg cttctgaatc   3840

caagtcattg ttacctgaat ttgcaaatta agttgtgata ttcgtgactg ttaaattcct   3900

gtaattagat taacctcttt gcttgcttgt ttgttttctc tcctatttta gcttaaagta   3960

tcagtggttg agaagagctt ttcggacctg ttactacccc aagctgtgta atatacttgt   4020

ataacagaaa taccttctat acaaaccttt ttttctactt ttagatagaa atgtctactt   4080

tttcagcagt tctgtgaatt aaagagcaga gtgactgtgg gtctggaatg gctggtgtac   4140

ttgggaatgt actatcagga ttttacagca atgctgggaa atgacaggga aaatgacagg   4200

aatgaatctc accagatttt ttatgtactc agcagagcct tgagttacgg tgtttatttt   4260

ccaatcaagt gaagatatct cctacttctc ctactggaac atctcagctt ctgcagtgaa   4320

gaaaaattcc tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa aaaatcattt   4380

aaatgatcct ttgttcacgg ctctccttaa tgactgagtg aacagttcct atctgtatat   4440

ttgactaaac cttttcctaa gctatctctc atggttccta tgttttttta tcataattaa   4500

aagcaaaacc atctggatca cctaacagtc agaggtcagt atctcagcgt gtgaattata   4560

gaggaaatac agagagaacc tcttccactt ttacttttcg tccaaataaa atgcatggtg   4620

taccagaagt tgaagatcgg gttgaggatt ggggctagct cgatgacact aaggccccaa   4680

catcgcggga cctgctgtgg cgcggattct taggaacgct gttctagccg gccccctctc   4740

caggggtcgc cgtggccggc attatttcct agttcttctt gtaaccctga ggtgccagcg   4800

cggggagtga ggaggggtca gggggctaag gatgcaacct ctgacgttct gcgccttcct   4860

aggagagtct tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa taccagctct   4920

acaagaagct aggctctgtg acggcatagt tttcagtagc tttatcacaa tattcacaat   4980

ggagaattat atgacatggt agcagaaata ggccctttta tgtgttgctt ctattttacc   5040

tcaaattgta gatatagggt aatcaataaa atccatccat gcctttcaca cactaagt     5098


<210>  4899
<211>  885
<212>  PRT
<213>  Homo sapiens

<400>  4899

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln 
        195                 200                 205


His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile 
    210                 215                 220


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
225                 230                 235                 240


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
                245                 250                 255


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
            260                 265                 270


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
        275                 280                 285


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
    290                 295                 300


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
305                 310                 315                 320


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
                325                 330                 335


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
            340                 345                 350


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
        355                 360                 365


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
    370                 375                 380


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
385                 390                 395                 400


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
                405                 410                 415


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
            420                 425                 430


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
        435                 440                 445


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
    450                 455                 460


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
465                 470                 475                 480


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
                485                 490                 495


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
            500                 505                 510


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
        515                 520                 525


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
    530                 535                 540


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
545                 550                 555                 560


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
                565                 570                 575


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
            580                 585                 590


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
        595                 600                 605


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
    610                 615                 620


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
625                 630                 635                 640


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
                645                 650                 655


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
            660                 665                 670


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
        675                 680                 685


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
    690                 695                 700


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
705                 710                 715                 720


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
                725                 730                 735


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
            740                 745                 750


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
        755                 760                 765


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
    770                 775                 780


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
785                 790                 795                 800


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
                805                 810                 815


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro 
            820                 825                 830


Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly 
        835                 840                 845


Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala 
    850                 855                 860


Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu 
865                 870                 875                 880


Pro Asp Pro Thr Trp 
                885


<210>  4900
<211>  7176
<212>  DNA
<213>  Homo sapiens

<400>  4900
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1980

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   2040

catatcctgt gtttgaatca aacccggagt tcttgtatgt ggaaggcttg ccagagggga   2100

ttcccttccg aagccctacc tggtttggaa ttccacgact tgaaaggatc gtccgcggga   2160

gtaataaaat caagttcgtt gttaaaaaac ctgaactagt tatttcctac ttgcctcctg   2220

ggatggctag taaaataaac actaaagctt tgcagtcccc caaaagacca cgaagtcctg   2280

ggagtaattc aaaggttcct gaaattgagg tcaccgtgga aggccctaat aacaacaatc   2340

ctcaaacctc agctgttcga accccgaccc agactaacgg ttctaacgtt cccttcaagc   2400

cacgagggag agagttttcc tttgaggcct ggaatgccaa aatcacggac ctaaaacaga   2460

aagttgaaaa tctcttcaat gagaaatgtg gggaagctct tggccttaaa caagctgtga   2520

aggtgccgtt cgcgttattt gagtctttcc cggaagactt ttatgtggaa ggcttacctg   2580

agggtgtgcc attccgaaga ccatcgactt ttggcattcc gaggctggag aagatactca   2640

gaaacaaagc caaaattaag ttcatcatta aaaagcccga aatgtttgag acggcgatta   2700

aggagagcac ctcctctaag agccctccca gaaaaataaa ttcatcaccc aatgttaata   2760

ctactgcatc aggtgttgaa gaccttaaca tcattcaggt gacaattcca gatgatgata   2820

atgaaagact ctcgaaagtt gaaaaagcta gacagctaag agaacaagtg aatgacctct   2880

ttagtcggaa atttggtgaa gctattggta tgggttttcc tgtgaaagtt ccctacagga   2940

aaatcacaat taaccctggc tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca   3000

aagcccccag ctacctggaa atcagctcca tgagaaggat cttagactct gccgagttta   3060

tcaaattcac ggtcattagg taagtgagag tttcctgctt agtcacagga gcgaatctgg   3120

agctcatgag gctgactctt ctaaaatgca gccacaggta gtcatcgaat ccggcttcct   3180

atgctgtgca atcaacaaat caaaataact tgtgtcatca ttagaatgtc agatgtgctt   3240

ctacgaacta agctgactct tttaattctt tggcaaaggg ttggcaaact aggactgttt   3300

gccaaattca ggctgcctcc tatttttaga gtcttcctga aacacagcta cacccgtatt   3360

atccatggct gctttcctgt cacagtgagt aagtagctgg gactgagaag gcatggcctc   3420

caaagtctaa aatatttact ctctagcact ttgtagaaaa accttagcta ggcacagtgg   3480

ctaacgcctg taatcccagc attttgggag gccaaggcag gcagatcacc tgaggtcagg   3540

agttccagac cagcctggcc aacatggtga aatcccatct ctacaaaaat aaaacagtta   3600

gctgggcatg atggcgggtg cctgtaatcc cagctactcg ggaggctgag gcaggatagt   3660

cgcttgaacc caggaggtgg aggttgcaat gagccaagat catgccactg cactccagcc   3720

tggacgacag agtgagactc catcacaaga aaaaaagaac tttgtcaacc tctgtcttag   3780

ggcgccttgt cacaggcttc gggtcagacg gattcaacct tgcatcagcc atttgttagc   3840

caggtcactc tgttctttgt ctgtaaatga gattgatcgt tgttcccact gagagtgtca   3900

gctccttccc gtagagcagg catgatgatt gtactcacct ctgacaccat tgtgagtgcc   3960

acattccttc ccacgtcctt gtcactgtaa gagatgccca cctgagcacc aaccccaggt   4020

tatcttcccc tttgtcttcc agccccccag aaacagctac gactcaacct acccaatcat   4080

ttcatcatca gattgccact gtctctagtt caggtctctt gggactggca ctcagaaatc   4140

tcataataaa tcctcttgag gcttctcata cactcgtctt cttccaatct tctttccctc   4200

aaaatctcat attttggttc cacttcaccc accgtcattc tccatatcac tcccaggagt   4260

taggcaaaaa gccccttccg ttcttccgta tgttaaactt agaatcactc tgttccctgc   4320

tctgcgtttc tattttttgt ttttcctcca tttactagta gcttaacact ttctaacagt   4380

gttcttatta ttgatacgta tctatctctt ccataagctt ataaggtcac ggataatact   4440

tctcattgta gtacgtaaat gacgtgggct agatatgagt tgaataaaca gttatacctg   4500

taaattctta cagagtgaaa ataaattgtt atactttaca atttgtttct ctctttagac   4560

catttccagg acttgtgatt aataaccgtg agtattttgt gaagtgtttt gtttttgttt   4620

tttcctgggg tctgacgtgt gtgcgtgtga gtgtgtatac atgcttaacg tatatcacgt   4680

tacttcacct atgtcagtaa ccaggccaaa tacttgtttt agccctcagt aaaaacacca   4740

ggcacttcct agttgtaaaa ttattcaagc ttcttaactt cctatcctcg atgcacttaa   4800

tcataaaatg gtaataatag caccgatttt gggggagtcg ttccagtaga tggaaagcat   4860

ctggaacagg tgtcagcaag ctcctgccga cgtgtatgca taaagtttta ttgaaaccac   4920

catcgtgtcc atttgtttat ggcagaactg agagatggca gcagcaagtg tgtgcctgca   4980

aaacctaaaa tatttactaa ttggctctgc aagaaaagag tttgcatccc cctaacctag   5040

aacagtgtct agcctctagt atgtgtttag cctacagtat gtgctcagcg aatacaatct   5100

atatttatta ctgcttttat gactgttata attactgtgc ttggatttcg ttacaaagta   5160

agtcacaatg tgcctgcttc tgttagtatt tcagcacagt gcctggcaca catggggctc   5220

tcaaatattg ctgagcgagt gaacaaatgt cctttcaatt ccttaacgtt gatgtcattt   5280

tcaatagtat tttgagccaa acttaatttt gcgagtgtgt tttgttttct taactttatt   5340

attaaaaatg tataaaagtg aggccaggcg tggtggctca cgcctgtaat cccagcagtt   5400

tgggaggctg aggcaggcgg atcagttgag gttgggagtt ggagaccagc ccgtccaaca   5460

tggtgaaagc ctgtctctac taaaaataca aaaatcagct gggtgtggtg gcgcgtgcct   5520

gtaatcccag ctactcagga ggctgaggca ggagagttgc ttgaatccta gaggtggagg   5580

ttgcagtgag ctgagatcgt gccattgcac tccagcctgg gcaacaagag caaaactctg   5640

tcccaataaa taaataaata aaatgttctc ttttgttcct gttcttgtgc ggtagtgtgg   5700

tatagagttt tatggtaatt actgtgaatt agtgattctg agggacatat cagaactctg   5760

aggtttgttt ccttctcatc ttgagggaaa cagcaaatgt atgttaaaat gcttttccaa   5820

gggaacaaca catccttaca ttatttaaac caatctgctt cattttcaga gctggttgat   5880

cagagtgagt cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt   5940

ccagccacag aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac   6000

cccacgtggt agacctcttc cctcctaggc ttaaagtatc agtggttgag aagagctttt   6060

cggacctgtt actaccccaa gctgtgtaat atacttgtat aacagaaata ccttctatac   6120

aaaccttttt ttctactttt agatagaaat gtctactttt tcagcagttc tgtgaattaa   6180

agagcagagt gactgtgggt ctggaatggc tggtgtactt gggaatgtac tatcaggatt   6240

ttacagcaat gctgggaaat gacagggaaa atgacaggaa tgaatctcac cagatttttt   6300

atgtactcag cagagccttg agttacggtg tttattttcc aatcaagtga agatatctcc   6360

tacttctcct actggaacat ctcagcttct gcagtgaaga aaaattcctg tgatagttca   6420

gttctttagt ttttctattt gaaaaaaaaa aatcatttaa atgatccttt gttcacggct   6480

ctccttaatg actgagtgaa cagttcctat ctgtatattt gactaaacct tttcctaagc   6540

tatctctcat ggttcctatg tttttttatc ataattaaaa gcaaaaccat ctggatcacc   6600

taacagtcag aggtcagtat ctcagcgtgt gaattataga ggaaatacag agagaacctc   6660

ttccactttt acttttcgtc caaataaaat gcatggtgta ccagaagttg aagatcgggt   6720

tgaggattgg ggctagctcg atgacactaa ggccccaaca tcgcgggacc tgctgtggcg   6780

cggattctta ggaacgctgt tctagccggc cccctctcca ggggtcgccg tggccggcat   6840

tatttcctag ttcttcttgt aaccctgagg tgccagcgcg gggagtgagg aggggtcagg   6900

gggctaagga tgcaacctct gacgttctgc gccttcctag gagagtctta catgtgttga   6960

gatttcacaa gcaatgcgag ttgtaaaata ccagctctac aagaagctag gctctgtgac   7020

ggcatagttt tcagtagctt tatcacaata ttcacaatgg agaattatat gacatggtag   7080

cagaaatagg cccttttatg tgttgcttct attttacctc aaattgtaga tatagggtaa   7140

tcaataaaat ccatccatgc ctttcacaca ctaagt                             7176


<210>  4901
<211>  832
<212>  PRT
<213>  Homo sapiens

<400>  4901

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
    450                 455                 460


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
465                 470                 475                 480


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
                485                 490                 495


Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr 
            500                 505                 510


Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys 
        515                 520                 525


Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro 
    530                 535                 540


Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys 
545                 550                 555                 560


Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val 
                565                 570                 575


Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg 
            580                 585                 590


Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly 
        595                 600                 605


Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys 
    610                 615                 620


Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly 
625                 630                 635                 640


Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro 
                645                 650                 655


Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg 
            660                 665                 670


Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys 
        675                 680                 685


Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala 
    690                 695                 700


Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser 
705                 710                 715                 720


Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile 
                725                 730                 735


Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val 
            740                 745                 750


Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg 
        755                 760                 765


Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr 
    770                 775                 780


Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro 
785                 790                 795                 800


Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met 
                805                 810                 815


Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
            820                 825                 830


<210>  4902
<211>  4415
<212>  DNA
<213>  Homo sapiens

<400>  4902
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1980

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   2040

catatcctgt gtttgaatca aacccggagt tcttgtatgt ggaaggcttg ccagagggga   2100

ttcccttccg aagccctacc tggtttggaa ttccacgact tgaaaggatc gtccgcggga   2160

gtaataaaat caagttcgtt gttaaaaaac ctgaactagt tatttcctac ttgcctcctg   2220

ggatggctag taaaataaac actaaagctt tgcagtcccc caaaagacca cgaagtcctg   2280

ggagtaattc aaaggttcct gaaattgagg tcaccgtgga aggccctaat aacaacaatc   2340

ctcaaacctc agctgttcga accccgaccc agactaacgg ttctaacgtt cccttcaagc   2400

cacgagggag agagttttcc tttgaggcct ggaatgccaa aatcacggac ctaaaacaga   2460

aagttgaaaa tctcttcaat gagaaatgtg gggaagctct tggccttaaa caagctgtga   2520

aggtgccgtt cgcgttattt gagtctttcc cggaagactt ttatgtggaa ggcttacctg   2580

agggtgtgcc attccgaaga ccatcgactt ttggcattcc gaggctggag aagatactca   2640

gaaacaaagc caaaattaag ttcatcatta aaaagcccga aatgtttgag acggcgatta   2700

aggagagcac ctcctctaag agccctccca gaaaaataaa ttcatcaccc aatgttaata   2760

ctactgcatc aggtgttgaa gaccttaaca tcattcaggt gacaattcca gatgatgata   2820

atgaaagact ctcgaaagtt gaaaaagcta gacagctaag agaacaagtg aatgacctct   2880

ttagtcggaa atttggtgaa gctattggta tgggttttcc tgtgaaagtt ccctacagga   2940

aaatcacaat taaccctggc tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca   3000

aagcccccag ctacctggaa atcagctcca tgagaaggat cttagactct gccgagttta   3060

tcaaattcac ggtcattaga ccatttccag gacttgtgat taataaccag ctggttgatc   3120

agagtgagtc agaaggcccc gtgatacaag aatcagctga accaagccag ttggaagttc   3180

cagccacaga agaaataaaa gagactgatg gaagctctca gatcaagcaa gaaccagacc   3240

ccacgtggta gacctcttcc ctcctaggct taaagtatca gtggttgaga agagcttttc   3300

ggacctgtta ctaccccaag ctgtgtaata tacttgtata acagaaatac cttctataca   3360

aacctttttt tctactttta gatagaaatg tctacttttt cagcagttct gtgaattaaa   3420

gagcagagtg actgtgggtc tggaatggct ggtgtacttg ggaatgtact atcaggattt   3480

tacagcaatg ctgggaaatg acagggaaaa tgacaggaat gaatctcacc agatttttta   3540

tgtactcagc agagccttga gttacggtgt ttattttcca atcaagtgaa gatatctcct   3600

acttctccta ctggaacatc tcagcttctg cagtgaagaa aaattcctgt gatagttcag   3660

ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa tgatcctttg ttcacggctc   3720

tccttaatga ctgagtgaac agttcctatc tgtatatttg actaaacctt ttcctaagct   3780

atctctcatg gttcctatgt ttttttatca taattaaaag caaaaccatc tggatcacct   3840

aacagtcaga ggtcagtatc tcagcgtgtg aattatagag gaaatacaga gagaacctct   3900

tccactttta cttttcgtcc aaataaaatg catggtgtac cagaagttga agatcgggtt   3960

gaggattggg gctagctcga tgacactaag gccccaacat cgcgggacct gctgtggcgc   4020

ggattcttag gaacgctgtt ctagccggcc ccctctccag gggtcgccgt ggccggcatt   4080

atttcctagt tcttcttgta accctgaggt gccagcgcgg ggagtgagga ggggtcaggg   4140

ggctaaggat gcaacctctg acgttctgcg ccttcctagg agagtcttac atgtgttgag   4200

atttcacaag caatgcgagt tgtaaaatac cagctctaca agaagctagg ctctgtgacg   4260

gcatagtttt cagtagcttt atcacaatat tcacaatgga gaattatatg acatggtagc   4320

agaaataggc ccttttatgt gttgcttcta ttttacctca aattgtagat atagggtaat   4380

caataaaatc catccatgcc tttcacacac taagt                              4415


<210>  4903
<211>  888
<212>  PRT
<213>  Homo sapiens

<400>  4903

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
    450                 455                 460


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
465                 470                 475                 480


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
                485                 490                 495


Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr 
            500                 505                 510


Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys 
        515                 520                 525


Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro 
    530                 535                 540


Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys 
545                 550                 555                 560


Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val 
                565                 570                 575


Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg 
            580                 585                 590


Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly 
        595                 600                 605


Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys 
    610                 615                 620


Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly 
625                 630                 635                 640


Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro 
                645                 650                 655


Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg 
            660                 665                 670


Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys 
        675                 680                 685


Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala 
    690                 695                 700


Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser 
705                 710                 715                 720


Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile 
                725                 730                 735


Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val 
            740                 745                 750


Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg 
        755                 760                 765


Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr 
    770                 775                 780


Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro 
785                 790                 795                 800


Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met 
                805                 810                 815


Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
            820                 825                 830


Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu 
        835                 840                 845


Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu 
    850                 855                 860


Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile 
865                 870                 875                 880


Lys Gln Glu Pro Asp Pro Thr Trp 
                885


<210>  4904
<211>  5171
<212>  DNA
<213>  Homo sapiens

<400>  4904
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   2040

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2100

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2160

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2220

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2280

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2340

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2400

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2460

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2520

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2580

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2640

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2700

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2760

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2820

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2880

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   2940

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   3000

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3060

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3120

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3180

ttcacggtca ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt   3240

gagtcagaag gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc   3300

acagaaggta aaaggacctc ttccctccta gggtaaatca gcttctgtgt cagggatgct   3360

gtgtggtgtc catctgaacc ccctgcatac gcgtagctaa tgtgatctcc ccactttcac   3420

ataagatggt ggccctgcct tcagggaatg tgggagccag gtgggagcct tcccggatat   3480

ttaagctaga agattctaca gggagattct ccttggatca atatatgtct ctcagtcaaa   3540

gatgtaaaag cacttttgcc ttaaaaagaa tgttctgttt ctaaatagag tcaacgttgt   3600

cctcctcatt ggaattcact atgagtcaga atcattagac tgactttttt ttttccatag   3660

taatagtatt ttgcagagtc tcacagagct gcagatcttt tgttcatctt gcagagttaa   3720

caagtctgat cctgttagtc cagatttctt aaatttggcc aagttataat aggagcagta   3780

gcttgagacc cgaagtcagg aaactttgac aatggatttt tttttttaat ccagagactt   3840

gtactggaat ttgccttacc ctgtcagctc atggacttaa ggtttcatcc cgctttatga   3900

gtgcttctga atccaagtca ttgttacctg aatttgcaaa ttaagttgtg atattcgtga   3960

ctgttaaatt cctgtaatta gattaacctc tttgcttgct tgtttgtttt ctctcctatt   4020

ttagcttaaa gtatcagtgg ttgagaagag cttttcggac ctgttactac cccaagctgt   4080

gtaatatact tgtataacag aaataccttc tatacaaacc tttttttcta cttttagata   4140

gaaatgtcta ctttttcagc agttctgtga attaaagagc agagtgactg tgggtctgga   4200

atggctggtg tacttgggaa tgtactatca ggattttaca gcaatgctgg gaaatgacag   4260

ggaaaatgac aggaatgaat ctcaccagat tttttatgta ctcagcagag ccttgagtta   4320

cggtgtttat tttccaatca agtgaagata tctcctactt ctcctactgg aacatctcag   4380

cttctgcagt gaagaaaaat tcctgtgata gttcagttct ttagtttttc tatttgaaaa   4440

aaaaaaatca tttaaatgat cctttgttca cggctctcct taatgactga gtgaacagtt   4500

cctatctgta tatttgacta aaccttttcc taagctatct ctcatggttc ctatgttttt   4560

ttatcataat taaaagcaaa accatctgga tcacctaaca gtcagaggtc agtatctcag   4620

cgtgtgaatt atagaggaaa tacagagaga acctcttcca cttttacttt tcgtccaaat   4680

aaaatgcatg gtgtaccaga agttgaagat cgggttgagg attggggcta gctcgatgac   4740

actaaggccc caacatcgcg ggacctgctg tggcgcggat tcttaggaac gctgttctag   4800

ccggccccct ctccaggggt cgccgtggcc ggcattattt cctagttctt cttgtaaccc   4860

tgaggtgcca gcgcggggag tgaggagggg tcagggggct aaggatgcaa cctctgacgt   4920

tctgcgcctt cctaggagag tcttacatgt gttgagattt cacaagcaat gcgagttgta   4980

aaataccagc tctacaagaa gctaggctct gtgacggcat agttttcagt agctttatca   5040

caatattcac aatggagaat tatatgacat ggtagcagaa ataggccctt ttatgtgttg   5100

cttctatttt acctcaaatt gtagatatag ggtaatcaat aaaatccatc catgcctttc   5160

acacactaag t                                                        5171


<210>  4905
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  4905

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
    450                 455                 460


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
465                 470                 475


<210>  4906
<211>  4522
<212>  DNA
<213>  Homo sapiens

<400>  4906
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2040

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2100

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2160

tgaatcaaac ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag   2220

ccctacctgg tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa   2280

gttcgttgtt aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa   2340

aataaacact aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa   2400

ggttcctgaa attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc   2460

tgttcgaacc ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga   2520

gttttccttt gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct   2580

cttcaatgag aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc   2640

gttatttgag tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt   2700

ccgaagacca tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa   2760

aattaagttc atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc   2820

ctctaagagc cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg   2880

tgttgaagac cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc   2940

gaaagttgaa aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt   3000

tggtgaagct attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa   3060

ccctggctgt gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta   3120

cctggaaatc agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt   3180

cattagacca tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga   3240

aggccccgtg atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga   3300

aataaaagag actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac   3360

ctcttccctc ctaggcttaa agtatcagtg gttgagaaga gcttttcgga cctgttacta   3420

ccccaagctg tgtaatatac ttgtataaca gaaatacctt ctatacaaac ctttttttct   3480

acttttagat agaaatgtct actttttcag cagttctgtg aattaaagag cagagtgact   3540

gtgggtctgg aatggctggt gtacttggga atgtactatc aggattttac agcaatgctg   3600

ggaaatgaca gggaaaatga caggaatgaa tctcaccaga ttttttatgt actcagcaga   3660

gccttgagtt acggtgttta ttttccaatc aagtgaagat atctcctact tctcctactg   3720

gaacatctca gcttctgcag tgaagaaaaa ttcctgtgat agttcagttc tttagttttt   3780

ctatttgaaa aaaaaaaatc atttaaatga tcctttgttc acggctctcc ttaatgactg   3840

agtgaacagt tcctatctgt atatttgact aaaccttttc ctaagctatc tctcatggtt   3900

cctatgtttt tttatcataa ttaaaagcaa aaccatctgg atcacctaac agtcagaggt   3960

cagtatctca gcgtgtgaat tatagaggaa atacagagag aacctcttcc acttttactt   4020

ttcgtccaaa taaaatgcat ggtgtaccag aagttgaaga tcgggttgag gattggggct   4080

agctcgatga cactaaggcc ccaacatcgc gggacctgct gtggcgcgga ttcttaggaa   4140

cgctgttcta gccggccccc tctccagggg tcgccgtggc cggcattatt tcctagttct   4200

tcttgtaacc ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc taaggatgca   4260

acctctgacg ttctgcgcct tcctaggaga gtcttacatg tgttgagatt tcacaagcaa   4320

tgcgagttgt aaaataccag ctctacaaga agctaggctc tgtgacggca tagttttcag   4380

tagctttatc acaatattca caatggagaa ttatatgaca tggtagcaga aataggccct   4440

tttatgtgtt gcttctattt tacctcaaat tgtagatata gggtaatcaa taaaatccat   4500

ccatgccttt cacacactaa gt                                            4522


<210>  4907
<211>  978
<212>  PRT
<213>  Homo sapiens

<400>  4907

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu 
            580                 585                 590


Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg 
        595                 600                 605


Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys 
    610                 615                 620


Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys 
625                 630                 635                 640


Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly 
                645                 650                 655


Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn 
            660                 665                 670


Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn 
        675                 680                 685


Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu 
    690                 695                 700


Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu 
705                 710                 715                 720


Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys 
                725                 730                 735


Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu 
            740                 745                 750


Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile 
        755                 760                 765


Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile 
    770                 775                 780


Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser 
785                 790                 795                 800


Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr 
                805                 810                 815


Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro 
            820                 825                 830


Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu 
        835                 840                 845


Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile 
    850                 855                 860


Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn 
865                 870                 875                 880


Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys 
                885                 890                 895


Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser 
            900                 905                 910


Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val 
        915                 920                 925


Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile 
    930                 935                 940


Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu 
945                 950                 955                 960


Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro 
                965                 970                 975


Thr Trp 



<210>  4908
<211>  5159
<212>  DNA
<213>  Homo sapiens

<400>  4908
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgcttaga tttgttgaca gcggtttcct ggagtgctgt   1980

cttgagaacg attctgagga ggctcagcaa gaaagagtgt ttcagttgat tgggtgtgtc   2040

tgtcatggag aaggaactca agctcttgga ctcaccgagg cagtaaaagt accatatcct   2100

gtgtttgaat caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc   2160

cgaagcccta cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa   2220

atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct   2280

agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat   2340

tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc   2400

tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg   2460

agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa   2520

aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg   2580

ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg   2640

ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa   2700

gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc   2760

acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca   2820

tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga   2880

ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg   2940

aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca   3000

attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt caaagccccc   3060

agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc   3120

acggtcatta gaccatttcc aggacttgtg attaataacc agctggttga tcagagtgag   3180

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   3240

gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga ccccacgtgg   3300

tagacctctt ccctcctagg gtaaatcagc ttctgtgtca gggatgctgt gtggtgtcca   3360

tctgaacccc ctgcatacgc gtagctaatg tgatctcccc actttcacat aagatggtgg   3420

ccctgccttc agggaatgtg ggagccaggt gggagccttc ccggatattt aagctagaag   3480

attctacagg gagattctcc ttggatcaat atatgtctct cagtcaaaga tgtaaaagca   3540

cttttgcctt aaaaagaatg ttctgtttct aaatagagtc aacgttgtcc tcctcattgg   3600

aattcactat gagtcagaat cattagactg actttttttt ttccatagta atagtatttt   3660

gcagagtctc acagagctgc agatcttttg ttcatcttgc agagttaaca agtctgatcc   3720

tgttagtcca gatttcttaa atttggccaa gttataatag gagcagtagc ttgagacccg   3780

aagtcaggaa actttgacaa tggatttttt tttttaatcc agagacttgt actggaattt   3840

gccttaccct gtcagctcat ggacttaagg tttcatcccg ctttatgagt gcttctgaat   3900

ccaagtcatt gttacctgaa tttgcaaatt aagttgtgat attcgtgact gttaaattcc   3960

tgtaattaga ttaacctctt tgcttgcttg tttgttttct ctcctatttt agcttaaagt   4020

atcagtggtt gagaagagct tttcggacct gttactaccc caagctgtgt aatatacttg   4080

tataacagaa ataccttcta tacaaacctt tttttctact tttagataga aatgtctact   4140

ttttcagcag ttctgtgaat taaagagcag agtgactgtg ggtctggaat ggctggtgta   4200

cttgggaatg tactatcagg attttacagc aatgctggga aatgacaggg aaaatgacag   4260

gaatgaatct caccagattt tttatgtact cagcagagcc ttgagttacg gtgtttattt   4320

tccaatcaag tgaagatatc tcctacttct cctactggaa catctcagct tctgcagtga   4380

agaaaaattc ctgtgatagt tcagttcttt agtttttcta tttgaaaaaa aaaaatcatt   4440

taaatgatcc tttgttcacg gctctcctta atgactgagt gaacagttcc tatctgtata   4500

tttgactaaa ccttttccta agctatctct catggttcct atgttttttt atcataatta   4560

aaagcaaaac catctggatc acctaacagt cagaggtcag tatctcagcg tgtgaattat   4620

agaggaaata cagagagaac ctcttccact tttacttttc gtccaaataa aatgcatggt   4680

gtaccagaag ttgaagatcg ggttgaggat tggggctagc tcgatgacac taaggcccca   4740

acatcgcggg acctgctgtg gcgcggattc ttaggaacgc tgttctagcc ggccccctct   4800

ccaggggtcg ccgtggccgg cattatttcc tagttcttct tgtaaccctg aggtgccagc   4860

gcggggagtg aggaggggtc agggggctaa ggatgcaacc tctgacgttc tgcgccttcc   4920

taggagagtc ttacatgtgt tgagatttca caagcaatgc gagttgtaaa ataccagctc   4980

tacaagaagc taggctctgt gacggcatag ttttcagtag ctttatcaca atattcacaa   5040

tggagaatta tatgacatgg tagcagaaat aggccctttt atgtgttgct tctattttac   5100

ctcaaattgt agatataggg taatcaataa aatccatcca tgcctttcac acactaagt    5159


<210>  4909
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  4909

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
            420                 425                 430


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
        435                 440                 445


Phe Asn Leu Lys Phe Ala 
    450


<210>  4910
<211>  4987
<212>  DNA
<213>  Homo sapiens

<400>  4910
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   1980

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   2040

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2100

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2160

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2220

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2280

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2340

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2400

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2460

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2520

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2580

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2640

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2700

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2760

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2820

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2880

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   2940

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   3000

cggtcattag accatttcca ggacttgtga ttaataacca gctggttgat cagagtgagt   3060

cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt ccagccacag   3120

aaggtaaaag gacctcttcc ctcctagggt aaatcagctt ctgtgtcagg gatgctgtgt   3180

ggtgtccatc tgaaccccct gcatacgcgt agctaatgtg atctccccac tttcacataa   3240

gatggtggcc ctgccttcag ggaatgtggg agccaggtgg gagccttccc ggatatttaa   3300

gctagaagat tctacaggga gattctcctt ggatcaatat atgtctctca gtcaaagatg   3360

taaaagcact tttgccttaa aaagaatgtt ctgtttctaa atagagtcaa cgttgtcctc   3420

ctcattggaa ttcactatga gtcagaatca ttagactgac tttttttttt ccatagtaat   3480

agtattttgc agagtctcac agagctgcag atcttttgtt catcttgcag agttaacaag   3540

tctgatcctg ttagtccaga tttcttaaat ttggccaagt tataatagga gcagtagctt   3600

gagacccgaa gtcaggaaac tttgacaatg gatttttttt tttaatccag agacttgtac   3660

tggaatttgc cttaccctgt cagctcatgg acttaaggtt tcatcccgct ttatgagtgc   3720

ttctgaatcc aagtcattgt tacctgaatt tgcaaattaa gttgtgatat tcgtgactgt   3780

taaattcctg taattagatt aacctctttg cttgcttgtt tgttttctct cctattttag   3840

cttaaagtat cagtggttga gaagagcttt tcggacctgt tactacccca agctgtgtaa   3900

tatacttgta taacagaaat accttctata caaacctttt tttctacttt tagatagaaa   3960

tgtctacttt ttcagcagtt ctgtgaatta aagagcagag tgactgtggg tctggaatgg   4020

ctggtgtact tgggaatgta ctatcaggat tttacagcaa tgctgggaaa tgacagggaa   4080

aatgacagga atgaatctca ccagattttt tatgtactca gcagagcctt gagttacggt   4140

gtttattttc caatcaagtg aagatatctc ctacttctcc tactggaaca tctcagcttc   4200

tgcagtgaag aaaaattcct gtgatagttc agttctttag tttttctatt tgaaaaaaaa   4260

aaatcattta aatgatcctt tgttcacggc tctccttaat gactgagtga acagttccta   4320

tctgtatatt tgactaaacc ttttcctaag ctatctctca tggttcctat gtttttttat   4380

cataattaaa agcaaaacca tctggatcac ctaacagtca gaggtcagta tctcagcgtg   4440

tgaattatag aggaaataca gagagaacct cttccacttt tacttttcgt ccaaataaaa   4500

tgcatggtgt accagaagtt gaagatcggg ttgaggattg gggctagctc gatgacacta   4560

aggccccaac atcgcgggac ctgctgtggc gcggattctt aggaacgctg ttctagccgg   4620

ccccctctcc aggggtcgcc gtggccggca ttatttccta gttcttcttg taaccctgag   4680

gtgccagcgc ggggagtgag gaggggtcag ggggctaagg atgcaacctc tgacgttctg   4740

cgccttccta ggagagtctt acatgtgttg agatttcaca agcaatgcga gttgtaaaat   4800

accagctcta caagaagcta ggctctgtga cggcatagtt ttcagtagct ttatcacaat   4860

attcacaatg gagaattata tgacatggta gcagaaatag gcccttttat gtgttgcttc   4920

tattttacct caaattgtag atatagggta atcaataaaa tccatccatg cctttcacac   4980

actaagt                                                             4987


<210>  4911
<211>  855
<212>  PRT
<213>  Homo sapiens

<400>  4911

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
    450                 455                 460


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
465                 470                 475                 480


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
                485                 490                 495


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
            500                 505                 510


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
        515                 520                 525


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
    530                 535                 540


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
545                 550                 555                 560


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
                565                 570                 575


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
            580                 585                 590


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
        595                 600                 605


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
    610                 615                 620


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
625                 630                 635                 640


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
                645                 650                 655


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
            660                 665                 670


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
        675                 680                 685


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
    690                 695                 700


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
705                 710                 715                 720


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
                725                 730                 735


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
            740                 745                 750


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
        755                 760                 765


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
    770                 775                 780


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
785                 790                 795                 800


Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile 
                805                 810                 815


Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln 
            820                 825                 830


Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Gly Lys 
        835                 840                 845


Arg Thr Ser Ser Leu Leu Gly 
    850                 855


<210>  4912
<211>  4139
<212>  DNA
<213>  Homo sapiens

<400>  4912
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagctca agctcttgga ctcaccgagg   1980

cagtaaaagt accatatcct gtgtttgaat caaacccgga gttcttgtat gtggaaggct   2040

tgccagaggg gattcccttc cgaagcccta cctggtttgg aattccacga cttgaaagga   2100

tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa acctgaacta gttatttcct   2160

acttgcctcc tgggatggct agtaaaataa acactaaagc tttgcagtcc cccaaaagac   2220

cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta   2280

ataacaacaa tcctcaaacc tcagctgttc gaaccccgac ccagactaac ggttctaacg   2340

ttcccttcaa gccacgaggg agagagtttt cctttgaggc ctggaatgcc aaaatcacgg   2400

acctaaaaca gaaagttgaa aatctcttca atgagaaatg tggggaagct cttggcctta   2460

aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg   2520

aaggcttacc tgagggtgtg ccattccgaa gaccatcgac ttttggcatt ccgaggctgg   2580

agaagatact cagaaacaaa gccaaaatta agttcatcat taaaaagccc gaaatgtttg   2640

agacggcgat taaggagagc acctcctcta agagccctcc cagaaaaata aattcatcac   2700

ccaatgttaa tactactgca tcaggtgttg aagaccttaa catcattcag gtgacaattc   2760

cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta agagaacaag   2820

tgaatgacct ctttagtcgg aaatttggtg aagctattgg tatgggtttt cctgtgaaag   2880

ttccctacag gaaaatcaca attaaccctg gctgtgtggt ggttgatggc atgcccccgg   2940

gggtgtcctt caaagccccc agctacctgg aaatcagctc catgagaagg atcttagact   3000

ctgccgagtt tatcaaattc acggtcatta gaccatttcc aggacttgtg attaataacc   3060

agctggttga tcagagtgag tcagaaggcc ccgtgataca agaatcagct gaaccaagcc   3120

agttggaagt tccagccaca gaagaaataa aagagactga tggaagctct cagatcaagc   3180

aagaaccaga ccccacgtgg tagacctctt ccctcctagg cttaaagtat cagtggttga   3240

gaagagcttt tcggacctgt tactacccca agctgtagcc ttgagttacg gtgtttattt   3300

tccaatcaag tgaagatatc tcctacttct cctactggaa catctcagct tctgcagtga   3360

agaaaaattc ctgtgatagt tcagttcttt agtttttcta tttgaaaaaa aaaaatcatt   3420

taaatgatcc tttgttcacg gctctcctta atgactgagt gaacagttcc tatctgtata   3480

tttgactaaa ccttttccta agctatctct catggttcct atgttttttt atcataatta   3540

aaagcaaaac catctggatc acctaacagt cagaggtcag tatctcagcg tgtgaattat   3600

agaggaaata cagagagaac ctcttccact tttacttttc gtccaaataa aatgcatggt   3660

gtaccagaag ttgaagatcg ggttgaggat tggggctagc tcgatgacac taaggcccca   3720

acatcgcggg acctgctgtg gcgcggattc ttaggaacgc tgttctagcc ggccccctct   3780

ccaggggtcg ccgtggccgg cattatttcc tagttcttct tgtaaccctg aggtgccagc   3840

gcggggagtg aggaggggtc agggggctaa ggatgcaacc tctgacgttc tgcgccttcc   3900

taggagagtc ttacatgtgt tgagatttca caagcaatgc gagttgtaaa ataccagctc   3960

tacaagaagc taggctctgt gacggcatag ttttcagtag ctttatcaca atattcacaa   4020

tggagaatta tatgacatgg tagcagaaat aggccctttt atgtgttgct tctattttac   4080

ctcaaattgt agatataggg taatcaataa aatccatcca tgcctttcac acactaagt    4139


<210>  4913
<211>  933
<212>  PRT
<213>  Homo sapiens

<400>  4913

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
        515                 520                 525


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
    530                 535                 540


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
545                 550                 555                 560


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
                565                 570                 575


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
            580                 585                 590


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
        595                 600                 605


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
    610                 615                 620


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
625                 630                 635                 640


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
                645                 650                 655


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
            660                 665                 670


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
        675                 680                 685


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
    690                 695                 700


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
705                 710                 715                 720


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
                725                 730                 735


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
            740                 745                 750


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
        755                 760                 765


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
    770                 775                 780


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
785                 790                 795                 800


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
                805                 810                 815


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
            820                 825                 830


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
        835                 840                 845


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
    850                 855                 860


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro 
865                 870                 875                 880


Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly 
                885                 890                 895


Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala 
            900                 905                 910


Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu 
        915                 920                 925


Pro Asp Pro Thr Trp 
    930


<210>  4914
<211>  3958
<212>  DNA
<213>  Homo sapiens

<400>  4914
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagc   2100

tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc   2160

ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc ctacctggtt   2220

tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa   2280

aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa taaacactaa   2340

agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg ttcctgaaat   2400

tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg ttcgaacccc   2460

gacccagact aacggttcta acgttccctt caagccacga gggagagagt tttcctttga   2520

ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct tcaatgagaa   2580

atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc   2640

tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc gaagaccatc   2700

gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa ttaagttcat   2760

cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct ctaagagccc   2820

tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg ttgaagacct   2880

taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga aagttgaaaa   2940

agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg gtgaagctat   3000

tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc ctggctgtgt   3060

ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc tggaaatcag   3120

ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca ttagaccatt   3180

tccaggactt gtgattaata accagctggt tgatcagagt gagtcagaag gccccgtgat   3240

acaagaatca gctgaaccaa gccagttgga agttccagcc acagaagaaa taaaagagac   3300

tgatggaagc tctcagatca agcaagaacc agaccccacg tggtagacct cttccctcct   3360

aggcaaaacc atctggatca cctaacagtc agaggtcagt atctcagcgt gtgaattata   3420

gaggaaatac agagagaacc tcttccactt ttacttttcg tccaaataaa atgcatggtg   3480

taccagaagt tgaagatcgg gttgaggatt ggggctagct cgatgacact aaggccccaa   3540

catcgcggga cctgctgtgg cgcggattct taggaacgct gttctagccg gccccctctc   3600

caggggtcgc cgtggccggc attatttcct agttcttctt gtaaccctga ggtgccagcg   3660

cggggagtga ggaggggtca gggggctaag gatgcaacct ctgacgttct gcgccttcct   3720

aggagagtct tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa taccagctct   3780

acaagaagct aggctctgtg acggcatagt tttcagtagc tttatcacaa tattcacaat   3840

ggagaattat atgacatggt agcagaaata ggccctttta tgtgttgctt ctattttacc   3900

tcaaattgta gatatagggt aatcaataaa atccatccat gcctttcaca cactaagt     3958


<210>  4915
<211>  974
<212>  PRT
<213>  Homo sapiens

<400>  4915

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala 
545                 550                 555                 560


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
                565                 570                 575


Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile 
            580                 585                 590


Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile 
        595                 600                 605


Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu 
    610                 615                 620


Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys 
625                 630                 635                 640


Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys 
                645                 650                 655


Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro 
            660                 665                 670


Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val 
        675                 680                 685


Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala 
    690                 695                 700


Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys 
705                 710                 715                 720


Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala 
                725                 730                 735


Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu 
            740                 745                 750


Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu 
        755                 760                 765


Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro 
    770                 775                 780


Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro 
785                 790                 795                 800


Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly 
                805                 810                 815


Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn 
            820                 825                 830


Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val 
        835                 840                 845


Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe 
    850                 855                 860


Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val 
865                 870                 875                 880


Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr 
                885                 890                 895


Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile 
            900                 905                 910


Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln 
        915                 920                 925


Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala 
    930                 935                 940


Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr 
945                 950                 955                 960


Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
                965                 970


<210>  4916
<211>  4527
<212>  DNA
<213>  Homo sapiens

<400>  4916
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1980

aagagatttt taatttgaaa tttgcttaga tttgttgaca gcggtttcct ggagtgctgt   2040

cttgagaacg attctgagga ggctcagcaa gaaagagtgt ttcagttgat tgggtgtgtc   2100

tgtcatggag aaggaactca agctcttgga ctcaccgagg cagtaaaagt accatatcct   2160

gtgtttgaat caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc   2220

cgaagcccta cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa   2280

atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct   2340

agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat   2400

tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc   2460

tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg   2520

agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa   2580

aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg   2640

ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg   2700

ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa   2760

gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc   2820

acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca   2880

tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga   2940

ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg   3000

aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca   3060

attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt caaagccccc   3120

agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc   3180

acggtcatta gaccatttcc aggacttgtg attaataacc agctggttga tcagagtgag   3240

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   3300

gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga ccccacgtgg   3360

tagacctctt ccctcctagg cttaaagtat cagtggttga gaagagcttt tcggacctgt   3420

tactacccca agctgtgtaa tatacttgta taacagaaat accttctata caaacctttt   3480

tttctacttt tagatagaaa tgtctacttt ttcagcagtt ctgtgaatta aagagcagag   3540

tgactgtggg tctggaatgg ctggtgtact tgggaatgta ctatcaggat tttacagcaa   3600

tgctgggaaa tgacagggaa aatgacagga atgaatctca ccagattttt tatgtactca   3660

gcagagcctt gagttacggt gtttattttc caatcaagtg aagatatctc ctacttctcc   3720

tactggaaca tctcagcttc tgcagtgaag aaaaattcct gtgatagttc agttctttag   3780

tttttctatt tgaaaaaaaa aaatcattta aatgatcctt tgttcacggc tctccttaat   3840

gactgagtga acagttccta tctgtatatt tgactaaacc ttttcctaag ctatctctca   3900

tggttcctat gtttttttat cataattaaa agcaaaacca tctggatcac ctaacagtca   3960

gaggtcagta tctcagcgtg tgaattatag aggaaataca gagagaacct cttccacttt   4020

tacttttcgt ccaaataaaa tgcatggtgt accagaagtt gaagatcggg ttgaggattg   4080

gggctagctc gatgacacta aggccccaac atcgcgggac ctgctgtggc gcggattctt   4140

aggaacgctg ttctagccgg ccccctctcc aggggtcgcc gtggccggca ttatttccta   4200

gttcttcttg taaccctgag gtgccagcgc ggggagtgag gaggggtcag ggggctaagg   4260

atgcaacctc tgacgttctg cgccttccta ggagagtctt acatgtgttg agatttcaca   4320

agcaatgcga gttgtaaaat accagctcta caagaagcta ggctctgtga cggcatagtt   4380

ttcagtagct ttatcacaat attcacaatg gagaattata tgacatggta gcagaaatag   4440

gcccttttat gtgttgcttc tattttacct caaattgtag atatagggta atcaataaaa   4500

tccatccatg cctttcacac actaagt                                       4527


<210>  4917
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  4917

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
    450                 455                 460


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
465                 470


<210>  4918
<211>  4270
<212>  DNA
<213>  Homo sapiens

<400>  4918
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   1980

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gcttagattt   2040

gttgacagcg gtttcctgga gtgctgtctt gagaacgatt ctgaggaggc tcagcaagaa   2100

agagtgtttc agttgattgg gtgtgtctgt catggagaag gaactcaagc tcttggactc   2160

accgaggcag taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgtatgtg   2220

gaaggcttgc cagaggggat tcccttccga agccctacct ggtttggaat tccacgactt   2280

gaaaggatcg tccgcgggag taataaaatc aagttcgttg ttaaaaaacc tgaactagtt   2340

atttcctact tgcctcctgg gatggctagt aaaataaaca ctaaagcttt gcagtccccc   2400

aaaagaccac gaagtcctgg gagtaattca aaggttcctg aaattgaggt caccgtggaa   2460

ggccctaata acaacaatcc tcaaacctca gctgttcgaa ccccgaccca gactaacggt   2520

tctaacgttc ccttcaagcc acgagggaga gagttttcct ttgaggcctg gaatgccaaa   2580

atcacggacc taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg ggaagctctt   2640

ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg agtctttccc ggaagacttt   2700

tatgtggaag gcttacctga gggtgtgcca ttccgaagac catcgacttt tggcattccg   2760

aggctggaga agatactcag aaacaaagcc aaaattaagt tcatcattaa aaagcccgaa   2820

atgtttgaga cggcgattaa ggagagcacc tcctctaaga gccctcccag aaaaataaat   2880

tcatcaccca atgttaatac tactgcatca ggtgttgaag accttaacat cattcaggtg   2940

acaattccag atgatgataa tgaaagactc tcgaaagttg aaaaagctag acagctaaga   3000

gaacaagtga atgacctctt tagtcggaaa tttggtgaag ctattggtat gggttttcct   3060

gtgaaagttc cctacaggaa aatcacaatt aaccctggct gtgtggtggt tgatggcatg   3120

cccccggggg tgtccttcaa agcccccagc tacctggaaa tcagctccat gagaaggatc   3180

ttagactctg ccgagtttat caaattcacg gtcattagac catttccagg acttgtgatt   3240

aataaccagc tggttgatca gagtgagtca gaaggccccg tgatacaaga atcagctgaa   3300

ccaagccagt tggaagttcc agccacagaa gaaataaaag agactgatgg aagctctcag   3360

atcaagcaag aaccagaccc cacgtggtag acctcttccc tcctaggagc cttgagttac   3420

ggtgtttatt ttccaatcaa gtgaagatat ctcctacttc tcctactgga acatctcagc   3480

ttctgcagtg aagaaaaatt cctgtgatag ttcagttctt tagtttttct atttgaaaaa   3540

aaaaaatcat ttaaatgatc ctttgttcac ggctctcctt aatgactgag tgaacagttc   3600

ctatctgtat atttgactaa accttttcct aagctatctc tcatggttcc tatgtttttt   3660

tatcataatt aaaagcaaaa ccatctggat cacctaacag tcagaggtca gtatctcagc   3720

gtgtgaatta tagaggaaat acagagagaa cctcttccac ttttactttt cgtccaaata   3780

aaatgcatgg tgtaccagaa gttgaagatc gggttgagga ttggggctag ctcgatgaca   3840

ctaaggcccc aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg ctgttctagc   3900

cggccccctc tccaggggtc gccgtggccg gcattatttc ctagttcttc ttgtaaccct   3960

gaggtgccag cgcggggagt gaggaggggt cagggggcta aggatgcaac ctctgacgtt   4020

ctgcgccttc ctaggagagt cttacatgtg ttgagatttc acaagcaatg cgagttgtaa   4080

aataccagct ctacaagaag ctaggctctg tgacggcata gttttcagta gctttatcac   4140

aatattcaca atggagaatt atatgacatg gtagcagaaa taggcccttt tatgtgttgc   4200

ttctatttta cctcaaattg tagatatagg gtaatcaata aaatccatcc atgcctttca   4260

cacactaagt                                                          4270


<210>  4919
<211>  544
<212>  PRT
<213>  Homo sapiens

<400>  4919

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile 
        515                 520                 525


Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  4920
<211>  4045
<212>  DNA
<213>  Homo sapiens

<400>  4920
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1860

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1920

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1980

aatcaaaccc ggagttcttg aaaggatcgt ccgcgggagt aataaaatca agttcgttgt   2040

taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta aaataaacac   2100

taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa aggttcctga   2160

aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag ctgttcgaac   2220

cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag agttttcctt   2280

tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc tcttcaatga   2340

gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg cgttatttga   2400

gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat tccgaagacc   2460

atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca aaattaagtt   2520

catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct cctctaagag   2580

ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag gtgttgaaga   2640

ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct cgaaagttga   2700

aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat ttggtgaagc   2760

tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta accctggctg   2820

tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct acctggaaat   2880

cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg tcattagacc   2940

atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag aaggccccgt   3000

gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag aaataaaaga   3060

gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga cctcttccct   3120

cctaggctta aagtatcagt ggttgagaag agcttttcgg acctgttact accccaagct   3180

gtagccttga gttacggtgt ttattttcca atcaagtgaa gatatctcct acttctccta   3240

ctggaacatc tcagcttctg cagtgaagaa aaattcctgt gatagttcag ttctttagtt   3300

tttctatttg aaaaaaaaaa atcatttaaa tgatcctttg ttcacggctc tccttaatga   3360

ctgagtgaac agttcctatc tgtatatttg actaaacctt ttcctaagct atctctcatg   3420

gttcctatgt ttttttatca taattaaaag caaaaccatc tggatcacct aacagtcaga   3480

ggtcagtatc tcagcgtgtg aattatagag gaaatacaga gagaacctct tccactttta   3540

cttttcgtcc aaataaaatg catggtgtac cagaagttga agatcgggtt gaggattggg   3600

gctagctcga tgacactaag gccccaacat cgcgggacct gctgtggcgc ggattcttag   3660

gaacgctgtt ctagccggcc ccctctccag gggtcgccgt ggccggcatt atttcctagt   3720

tcttcttgta accctgaggt gccagcgcgg ggagtgagga ggggtcaggg ggctaaggat   3780

gcaacctctg acgttctgcg ccttcctagg agagtcttac atgtgttgag atttcacaag   3840

caatgcgagt tgtaaaatac cagctctaca agaagctagg ctctgtgacg gcatagtttt   3900

cagtagcttt atcacaatat tcacaatgga gaattatatg acatggtagc agaaataggc   3960

ccttttatgt gttgcttcta ttttacctca aattgtagat atagggtaat caataaaatc   4020

catccatgcc tttcacacac taagt                                         4045


<210>  4921
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  4921

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg 
            420                 425                 430


Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe 
        435                 440                 445


Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val 
    450                 455                 460


Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile 
465                 470                 475                 480


Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
                485                 490


<210>  4922
<211>  7395
<212>  DNA
<213>  Homo sapiens

<400>  4922
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2040

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2100

tttgaaattt gcttagattt gttgacagcg gtttcctgga gtgctgtctt gagaacgatt   2160

ctgaggaggc tcagcaagaa agagtgtttc agttgattgg gtgtgtctgt catggagaag   2220

gaactcaagc tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa   2280

acccggagtt cttgtatgtg gaaggcttgc cagaggggat tcccttccga agccctacct   2340

ggtttggaat tccacgactt gaaaggatcg tccgcgggag taataaaatc aagttcgttg   2400

ttaaaaaacc tgaactagtt atttcctact tgcctcctgg gatggctagt aaaataaaca   2460

ctaaagcttt gcagtccccc aaaagaccac gaagtcctgg gagtaattca aaggttcctg   2520

aaattgaggt caccgtggaa ggccctaata acaacaatcc tcaaacctca gctgttcgaa   2580

ccccgaccca gactaacggt tctaacgttc ccttcaagcc acgagggaga gagttttcct   2640

ttgaggcctg gaatgccaaa atcacggacc taaaacagaa agttgaaaat ctcttcaatg   2700

agaaatgtgg ggaagctctt ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg   2760

agtctttccc ggaagacttt tatgtggaag gcttacctga gggtgtgcca ttccgaagac   2820

catcgacttt tggcattccg aggctggaga agatactcag aaacaaagcc aaaattaagt   2880

tcatcattaa aaagcccgaa atgtttgaga cggcgattaa ggagagcacc tcctctaaga   2940

gccctcccag aaaaataaat tcatcaccca atgttaatac tactgcatca ggtgttgaag   3000

accttaacat cattcaggtg acaattccag atgatgataa tgaaagactc tcgaaagttg   3060

aaaaagctag acagctaaga gaacaagtga atgacctctt tagtcggaaa tttggtgaag   3120

ctattggtat gggttttcct gtgaaagttc cctacaggaa aatcacaatt aaccctggct   3180

gtgtggtggt tgatggcatg cccccggggg tgtccttcaa agcccccagc tacctggaaa   3240

tcagctccat gagaaggatc ttagactctg ccgagtttat caaattcacg gtcattaggt   3300

aagtgagagt ttcctgctta gtcacaggag cgaatctgga gctcatgagg ctgactcttc   3360

taaaatgcag ccacaggtag tcatcgaatc cggcttccta tgctgtgcaa tcaacaaatc   3420

aaaataactt gtgtcatcat tagaatgtca gatgtgcttc tacgaactaa gctgactctt   3480

ttaattcttt ggcaaagggt tggcaaacta ggactgtttg ccaaattcag gctgcctcct   3540

atttttagag tcttcctgaa acacagctac acccgtatta tccatggctg ctttcctgtc   3600

acagtgagta agtagctggg actgagaagg catggcctcc aaagtctaaa atatttactc   3660

tctagcactt tgtagaaaaa ccttagctag gcacagtggc taacgcctgt aatcccagca   3720

ttttgggagg ccaaggcagg cagatcacct gaggtcagga gttccagacc agcctggcca   3780

acatggtgaa atcccatctc tacaaaaata aaacagttag ctgggcatga tggcgggtgc   3840

ctgtaatccc agctactcgg gaggctgagg caggatagtc gcttgaaccc aggaggtgga   3900

ggttgcaatg agccaagatc atgccactgc actccagcct ggacgacaga gtgagactcc   3960

atcacaagaa aaaaagaact ttgtcaacct ctgtcttagg gcgccttgtc acaggcttcg   4020

ggtcagacgg attcaacctt gcatcagcca tttgttagcc aggtcactct gttctttgtc   4080

tgtaaatgag attgatcgtt gttcccactg agagtgtcag ctccttcccg tagagcaggc   4140

atgatgattg tactcacctc tgacaccatt gtgagtgcca cattccttcc cacgtccttg   4200

tcactgtaag agatgcccac ctgagcacca accccaggtt atcttcccct ttgtcttcca   4260

gccccccaga aacagctacg actcaaccta cccaatcatt tcatcatcag attgccactg   4320

tctctagttc aggtctcttg ggactggcac tcagaaatct cataataaat cctcttgagg   4380

cttctcatac actcgtcttc ttccaatctt ctttccctca aaatctcata ttttggttcc   4440

acttcaccca ccgtcattct ccatatcact cccaggagtt aggcaaaaag ccccttccgt   4500

tcttccgtat gttaaactta gaatcactct gttccctgct ctgcgtttct attttttgtt   4560

tttcctccat ttactagtag cttaacactt tctaacagtg ttcttattat tgatacgtat   4620

ctatctcttc cataagctta taaggtcacg gataatactt ctcattgtag tacgtaaatg   4680

acgtgggcta gatatgagtt gaataaacag ttatacctgt aaattcttac agagtgaaaa   4740

taaattgtta tactttacaa tttgtttctc tctttagacc atttccagga cttgtgatta   4800

ataaccgtga gtattttgtg aagtgttttg tttttgtttt ttcctggggt ctgacgtgtg   4860

tgcgtgtgag tgtgtataca tgcttaacgt atatcacgtt acttcaccta tgtcagtaac   4920

caggccaaat acttgtttta gccctcagta aaaacaccag gcacttccta gttgtaaaat   4980

tattcaagct tcttaacttc ctatcctcga tgcacttaat cataaaatgg taataatagc   5040

accgattttg ggggagtcgt tccagtagat ggaaagcatc tggaacaggt gtcagcaagc   5100

tcctgccgac gtgtatgcat aaagttttat tgaaaccacc atcgtgtcca tttgtttatg   5160

gcagaactga gagatggcag cagcaagtgt gtgcctgcaa aacctaaaat atttactaat   5220

tggctctgca agaaaagagt ttgcatcccc ctaacctaga acagtgtcta gcctctagta   5280

tgtgtttagc ctacagtatg tgctcagcga atacaatcta tatttattac tgcttttatg   5340

actgttataa ttactgtgct tggatttcgt tacaaagtaa gtcacaatgt gcctgcttct   5400

gttagtattt cagcacagtg cctggcacac atggggctct caaatattgc tgagcgagtg   5460

aacaaatgtc ctttcaattc cttaacgttg atgtcatttt caatagtatt ttgagccaaa   5520

cttaattttg cgagtgtgtt ttgttttctt aactttatta ttaaaaatgt ataaaagtga   5580

ggccaggcgt ggtggctcac gcctgtaatc ccagcagttt gggaggctga ggcaggcgga   5640

tcagttgagg ttgggagttg gagaccagcc cgtccaacat ggtgaaagcc tgtctctact   5700

aaaaatacaa aaatcagctg ggtgtggtgg cgcgtgcctg taatcccagc tactcaggag   5760

gctgaggcag gagagttgct tgaatcctag aggtggaggt tgcagtgagc tgagatcgtg   5820

ccattgcact ccagcctggg caacaagagc aaaactctgt cccaataaat aaataaataa   5880

aatgttctct tttgttcctg ttcttgtgcg gtagtgtggt atagagtttt atggtaatta   5940

ctgtgaatta gtgattctga gggacatatc agaactctga ggtttgtttc cttctcatct   6000

tgagggaaac agcaaatgta tgttaaaatg cttttccaag ggaacaacac atccttacat   6060

tatttaaacc aatctgcttc attttcagag ctggttgatc agagtgagtc agaaggcccc   6120

gtgatacaag aatcagctga accaagccag ttggaagttc cagccacaga agaaataaaa   6180

gagactgatg gaagctctca gatcaagcaa gaaccagacc ccacgtggta gacctcttcc   6240

ctcctaggct taaagtatca gtggttgaga agagcttttc ggacctgtta ctaccccaag   6300

ctgtgtaata tacttgtata acagaaatac cttctataca aacctttttt tctactttta   6360

gatagaaatg tctacttttt cagcagttct gtgaattaaa gagcagagtg actgtgggtc   6420

tggaatggct ggtgtacttg ggaatgtact atcaggattt tacagcaatg ctgggaaatg   6480

acagggaaaa tgacaggaat gaatctcacc agatttttta tgtactcagc agagccttga   6540

gttacggtgt ttattttcca atcaagtgaa gatatctcct acttctccta ctggaacatc   6600

tcagcttctg cagtgaagaa aaattcctgt gatagttcag ttctttagtt tttctatttg   6660

aaaaaaaaaa atcatttaaa tgatcctttg ttcacggctc tccttaatga ctgagtgaac   6720

agttcctatc tgtatatttg actaaacctt ttcctaagct atctctcatg gttcctatgt   6780

ttttttatca taattaaaag caaaaccatc tggatcacct aacagtcaga ggtcagtatc   6840

tcagcgtgtg aattatagag gaaatacaga gagaacctct tccactttta cttttcgtcc   6900

aaataaaatg catggtgtac cagaagttga agatcgggtt gaggattggg gctagctcga   6960

tgacactaag gccccaacat cgcgggacct gctgtggcgc ggattcttag gaacgctgtt   7020

ctagccggcc ccctctccag gggtcgccgt ggccggcatt atttcctagt tcttcttgta   7080

accctgaggt gccagcgcgg ggagtgagga ggggtcaggg ggctaaggat gcaacctctg   7140

acgttctgcg ccttcctagg agagtcttac atgtgttgag atttcacaag caatgcgagt   7200

tgtaaaatac cagctctaca agaagctagg ctctgtgacg gcatagtttt cagtagcttt   7260

atcacaatat tcacaatgga gaattatatg acatggtagc agaaataggc ccttttatgt   7320

gttgcttcta ttttacctca aattgtagat atagggtaat caataaaatc catccatgcc   7380

tttcacacac taagt                                                    7395


<210>  4923
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  4923

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala 



<210>  4924
<211>  3963
<212>  DNA
<213>  Homo sapiens

<400>  4924
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2100

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2160

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2220

tgaatcaaac ccggagttct tgaaaggatc gtccgcggga gtaataaaat caagttcgtt   2280

gttaaaaaac ctgaactagt tatttcctac ttgcctcctg ggatggctag taaaataaac   2340

actaaagctt tgcagtcccc caaaagacca cgaagtcctg ggagtaattc aaaggttcct   2400

gaaattgagg tcaccgtgga aggccctaat aacaacaatc ctcaaacctc agctgttcga   2460

accccgaccc agactaacgg ttctaacgtt cccttcaagc cacgagggag agagttttcc   2520

tttgaggcct ggaatgccaa aatcacggac ctaaaacaga aagttgaaaa tctcttcaat   2580

gagaaatgtg gggaagctct tggccttaaa caagctgtga aggtgccgtt cgcgttattt   2640

gagtctttcc cggaagactt ttatgtggaa ggcttacctg agggtgtgcc attccgaaga   2700

ccatcgactt ttggcattcc gaggctggag aagatactca gaaacaaagc caaaattaag   2760

ttcatcatta aaaagcccga aatgtttgag acggcgatta aggagagcac ctcctctaag   2820

agccctccca gaaaaataaa ttcatcaccc aatgttaata ctactgcatc aggtgttgaa   2880

gaccttaaca tcattcaggt gacaattcca gatgatgata atgaaagact ctcgaaagtt   2940

gaaaaagcta gacagctaag agaacaagtg aatgacctct ttagtcggaa atttggtgaa   3000

gctattggta tgggttttcc tgtgaaagtt ccctacagga aaatcacaat taaccctggc   3060

tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca aagcccccag ctacctggaa   3120

atcagctcca tgagaaggat cttagactct gccgagttta tcaaattcac ggtcattaga   3180

ccatttccag gacttgtgat taataaccag ctggttgatc agagtgagtc agaaggcccc   3240

gtgatacaag aatcagctga accaagccag ttggaagttc cagccacaga agaaataaaa   3300

gagactgatg gaagctctca gatcaagcaa gaaccagacc ccacgtggta gacctcttcc   3360

ctcctaggca aaaccatctg gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa   3420

ttatagagga aatacagaga gaacctcttc cacttttact tttcgtccaa ataaaatgca   3480

tggtgtacca gaagttgaag atcgggttga ggattggggc tagctcgatg acactaaggc   3540

cccaacatcg cgggacctgc tgtggcgcgg attcttagga acgctgttct agccggcccc   3600

ctctccaggg gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac cctgaggtgc   3660

cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc   3720

ttcctaggag agtcttacat gtgttgagat ttcacaagca atgcgagttg taaaatacca   3780

gctctacaag aagctaggct ctgtgacggc atagttttca gtagctttat cacaatattc   3840

acaatggaga attatatgac atggtagcag aaataggccc ttttatgtgt tgcttctatt   3900

ttacctcaaa ttgtagatat agggtaatca ataaaatcca tccatgcctt tcacacacta   3960

agt                                                                 3963


<210>  4925
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  4925

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys 
        595                 600                 605


Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu 
    610                 615                 620


Asn 
625


<210>  4926
<211>  7312
<212>  DNA
<213>  Homo sapiens

<400>  4926
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1980

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct tagatttgtt   2040

gacagcggtt tcctggagtg ctgtcttgag aacgattctg aggaggctca gcaagaaaga   2100

gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa ctcaagctct tggactcacc   2160

gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc cggagttctt gtatgtggaa   2220

ggcttgccag aggggattcc cttccgaagc cctacctggt ttggaattcc acgacttgaa   2280

aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta aaaaacctga actagttatt   2340

tcctacttgc ctcctgggat ggctagtaaa ataaacacta aagctttgca gtcccccaaa   2400

agaccacgaa gtcctgggag taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc   2460

cctaataaca acaatcctca aacctcagct gttcgaaccc cgacccagac taacggttct   2520

aacgttccct tcaagccacg agggagagag ttttcctttg aggcctggaa tgccaaaatc   2580

acggacctaa aacagaaagt tgaaaatctc ttcaatgaga aatgtgggga agctcttggc   2640

cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt ctttcccgga agacttttat   2700

gtggaaggct tacctgaggg tgtgccattc cgaagaccat cgacttttgg cattccgagg   2760

ctggagaaga tactcagaaa caaagccaaa attaagttca tcattaaaaa gcccgaaatg   2820

tttgagacgg cgattaagga gagcacctcc tctaagagcc ctcccagaaa aataaattca   2880

tcacccaatg ttaatactac tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca   2940

attccagatg atgataatga aagactctcg aaagttgaaa aagctagaca gctaagagaa   3000

caagtgaatg acctctttag tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg   3060

aaagttccct acaggaaaat cacaattaac cctggctgtg tggtggttga tggcatgccc   3120

ccgggggtgt ccttcaaagc ccccagctac ctggaaatca gctccatgag aaggatctta   3180

gactctgccg agtttatcaa attcacggtc attaggtaag tgagagtttc ctgcttagtc   3240

acaggagcga atctggagct catgaggctg actcttctaa aatgcagcca caggtagtca   3300

tcgaatccgg cttcctatgc tgtgcaatca acaaatcaaa ataacttgtg tcatcattag   3360

aatgtcagat gtgcttctac gaactaagct gactctttta attctttggc aaagggttgg   3420

caaactagga ctgtttgcca aattcaggct gcctcctatt tttagagtct tcctgaaaca   3480

cagctacacc cgtattatcc atggctgctt tcctgtcaca gtgagtaagt agctgggact   3540

gagaaggcat ggcctccaaa gtctaaaata tttactctct agcactttgt agaaaaacct   3600

tagctaggca cagtggctaa cgcctgtaat cccagcattt tgggaggcca aggcaggcag   3660

atcacctgag gtcaggagtt ccagaccagc ctggccaaca tggtgaaatc ccatctctac   3720

aaaaataaaa cagttagctg ggcatgatgg cgggtgcctg taatcccagc tactcgggag   3780

gctgaggcag gatagtcgct tgaacccagg aggtggaggt tgcaatgagc caagatcatg   3840

ccactgcact ccagcctgga cgacagagtg agactccatc acaagaaaaa aagaactttg   3900

tcaacctctg tcttagggcg ccttgtcaca ggcttcgggt cagacggatt caaccttgca   3960

tcagccattt gttagccagg tcactctgtt ctttgtctgt aaatgagatt gatcgttgtt   4020

cccactgaga gtgtcagctc cttcccgtag agcaggcatg atgattgtac tcacctctga   4080

caccattgtg agtgccacat tccttcccac gtccttgtca ctgtaagaga tgcccacctg   4140

agcaccaacc ccaggttatc ttcccctttg tcttccagcc ccccagaaac agctacgact   4200

caacctaccc aatcatttca tcatcagatt gccactgtct ctagttcagg tctcttggga   4260

ctggcactca gaaatctcat aataaatcct cttgaggctt ctcatacact cgtcttcttc   4320

caatcttctt tccctcaaaa tctcatattt tggttccact tcacccaccg tcattctcca   4380

tatcactccc aggagttagg caaaaagccc cttccgttct tccgtatgtt aaacttagaa   4440

tcactctgtt ccctgctctg cgtttctatt ttttgttttt cctccattta ctagtagctt   4500

aacactttct aacagtgttc ttattattga tacgtatcta tctcttccat aagcttataa   4560

ggtcacggat aatacttctc attgtagtac gtaaatgacg tgggctagat atgagttgaa   4620

taaacagtta tacctgtaaa ttcttacaga gtgaaaataa attgttatac tttacaattt   4680

gtttctctct ttagaccatt tccaggactt gtgattaata accgtgagta ttttgtgaag   4740

tgttttgttt ttgttttttc ctggggtctg acgtgtgtgc gtgtgagtgt gtatacatgc   4800

ttaacgtata tcacgttact tcacctatgt cagtaaccag gccaaatact tgttttagcc   4860

ctcagtaaaa acaccaggca cttcctagtt gtaaaattat tcaagcttct taacttccta   4920

tcctcgatgc acttaatcat aaaatggtaa taatagcacc gattttgggg gagtcgttcc   4980

agtagatgga aagcatctgg aacaggtgtc agcaagctcc tgccgacgtg tatgcataaa   5040

gttttattga aaccaccatc gtgtccattt gtttatggca gaactgagag atggcagcag   5100

caagtgtgtg cctgcaaaac ctaaaatatt tactaattgg ctctgcaaga aaagagtttg   5160

catcccccta acctagaaca gtgtctagcc tctagtatgt gtttagccta cagtatgtgc   5220

tcagcgaata caatctatat ttattactgc ttttatgact gttataatta ctgtgcttgg   5280

atttcgttac aaagtaagtc acaatgtgcc tgcttctgtt agtatttcag cacagtgcct   5340

ggcacacatg gggctctcaa atattgctga gcgagtgaac aaatgtcctt tcaattcctt   5400

aacgttgatg tcattttcaa tagtattttg agccaaactt aattttgcga gtgtgttttg   5460

ttttcttaac tttattatta aaaatgtata aaagtgaggc caggcgtggt ggctcacgcc   5520

tgtaatccca gcagtttggg aggctgaggc aggcggatca gttgaggttg ggagttggag   5580

accagcccgt ccaacatggt gaaagcctgt ctctactaaa aatacaaaaa tcagctgggt   5640

gtggtggcgc gtgcctgtaa tcccagctac tcaggaggct gaggcaggag agttgcttga   5700

atcctagagg tggaggttgc agtgagctga gatcgtgcca ttgcactcca gcctgggcaa   5760

caagagcaaa actctgtccc aataaataaa taaataaaat gttctctttt gttcctgttc   5820

ttgtgcggta gtgtggtata gagttttatg gtaattactg tgaattagtg attctgaggg   5880

acatatcaga actctgaggt ttgtttcctt ctcatcttga gggaaacagc aaatgtatgt   5940

taaaatgctt ttccaaggga acaacacatc cttacattat ttaaaccaat ctgcttcatt   6000

ttcagagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat cagctgaacc   6060

aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa gctctcagat   6120

caagcaagaa ccagacccca cgtggtagac ctcttccctc ctaggcttaa agtatcagtg   6180

gttgagaaga gcttttcgga cctgttacta ccccaagctg tgtaatatac ttgtataaca   6240

gaaatacctt ctatacaaac ctttttttct acttttagat agaaatgtct actttttcag   6300

cagttctgtg aattaaagag cagagtgact gtgggtctgg aatggctggt gtacttggga   6360

atgtactatc aggattttac agcaatgctg ggaaatgaca gggaaaatga caggaatgaa   6420

tctcaccaga ttttttatgt actcagcaga gccttgagtt acggtgttta ttttccaatc   6480

aagtgaagat atctcctact tctcctactg gaacatctca gcttctgcag tgaagaaaaa   6540

ttcctgtgat agttcagttc tttagttttt ctatttgaaa aaaaaaaatc atttaaatga   6600

tcctttgttc acggctctcc ttaatgactg agtgaacagt tcctatctgt atatttgact   6660

aaaccttttc ctaagctatc tctcatggtt cctatgtttt tttatcataa ttaaaagcaa   6720

aaccatctgg atcacctaac agtcagaggt cagtatctca gcgtgtgaat tatagaggaa   6780

atacagagag aacctcttcc acttttactt ttcgtccaaa taaaatgcat ggtgtaccag   6840

aagttgaaga tcgggttgag gattggggct agctcgatga cactaaggcc ccaacatcgc   6900

gggacctgct gtggcgcgga ttcttaggaa cgctgttcta gccggccccc tctccagggg   6960

tcgccgtggc cggcattatt tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga   7020

gtgaggaggg gtcagggggc taaggatgca acctctgacg ttctgcgcct tcctaggaga   7080

gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt aaaataccag ctctacaaga   7140

agctaggctc tgtgacggca tagttttcag tagctttatc acaatattca caatggagaa   7200

ttatatgaca tggtagcaga aataggccct tttatgtgtt gcttctattt tacctcaaat   7260

tgtagatata gggtaatcaa taaaatccat ccatgccttt cacacactaa gt           7312


<210>  4927
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  4927

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  4928
<211>  4095
<212>  DNA
<213>  Homo sapiens

<400>  4928
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1920

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   1980

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttgt   2040

atgtggaagg cttgccagag gggattccct tccgaagccc tacctggttt ggaattccac   2100

gacttgaaag gatcgtccgc gggagtaata aaatcaagtt cgttgttaaa aaacctgaac   2160

tagttatttc ctacttgcct cctgggatgg ctagtaaaat aaacactaaa gctttgcagt   2220

cccccaaaag accacgaagt cctgggagta attcaaaggt tcctgaaatt gaggtcaccg   2280

tggaaggccc taataacaac aatcctcaaa cctcagctgt tcgaaccccg acccagacta   2340

acggttctaa cgttcccttc aagccacgag ggagagagtt ttcctttgag gcctggaatg   2400

ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt caatgagaaa tgtggggaag   2460

ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt atttgagtct ttcccggaag   2520

acttttatgt ggaaggctta cctgagggtg tgccattccg aagaccatcg acttttggca   2580

ttccgaggct ggagaagata ctcagaaaca aagccaaaat taagttcatc attaaaaagc   2640

ccgaaatgtt tgagacggcg attaaggaga gcacctcctc taagagccct cccagaaaaa   2700

taaattcatc acccaatgtt aatactactg catcaggtgt tgaagacctt aacatcattc   2760

aggtgacaat tccagatgat gataatgaaa gactctcgaa agttgaaaaa gctagacagc   2820

taagagaaca agtgaatgac ctctttagtc ggaaatttgg tgaagctatt ggtatgggtt   2880

ttcctgtgaa agttccctac aggaaaatca caattaaccc tggctgtgtg gtggttgatg   2940

gcatgccccc gggggtgtcc ttcaaagccc ccagctacct ggaaatcagc tccatgagaa   3000

ggatcttaga ctctgccgag tttatcaaat tcacggtcat tagaccattt ccaggacttg   3060

tgattaataa ccagctggtt gatcagagtg agtcagaagg ccccgtgata caagaatcag   3120

ctgaaccaag ccagttggaa gttccagcca cagaagaaat aaaagagact gatggaagct   3180

ctcagatcaa gcaagaacca gaccccacgt ggtagacctc ttccctccta ggagccttga   3240

gttacggtgt ttattttcca atcaagtgaa gatatctcct acttctccta ctggaacatc   3300

tcagcttctg cagtgaagaa aaattcctgt gatagttcag ttctttagtt tttctatttg   3360

aaaaaaaaaa atcatttaaa tgatcctttg ttcacggctc tccttaatga ctgagtgaac   3420

agttcctatc tgtatatttg actaaacctt ttcctaagct atctctcatg gttcctatgt   3480

ttttttatca taattaaaag caaaaccatc tggatcacct aacagtcaga ggtcagtatc   3540

tcagcgtgtg aattatagag gaaatacaga gagaacctct tccactttta cttttcgtcc   3600

aaataaaatg catggtgtac cagaagttga agatcgggtt gaggattggg gctagctcga   3660

tgacactaag gccccaacat cgcgggacct gctgtggcgc ggattcttag gaacgctgtt   3720

ctagccggcc ccctctccag gggtcgccgt ggccggcatt atttcctagt tcttcttgta   3780

accctgaggt gccagcgcgg ggagtgagga ggggtcaggg ggctaaggat gcaacctctg   3840

acgttctgcg ccttcctagg agagtcttac atgtgttgag atttcacaag caatgcgagt   3900

tgtaaaatac cagctctaca agaagctagg ctctgtgacg gcatagtttt cagtagcttt   3960

atcacaatat tcacaatgga gaattatatg acatggtagc agaaataggc ccttttatgt   4020

gttgcttcta ttttacctca aattgtagat atagggtaat caataaaatc catccatgcc   4080

tttcacacac taagt                                                    4095


<210>  4929
<211>  937
<212>  PRT
<213>  Homo sapiens

<400>  4929

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
            500                 505                 510


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
        515                 520                 525


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
    530                 535                 540


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
545                 550                 555                 560


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
                565                 570                 575


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
            580                 585                 590


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
        595                 600                 605


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
    610                 615                 620


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
625                 630                 635                 640


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
                645                 650                 655


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
            660                 665                 670


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
        675                 680                 685


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
    690                 695                 700


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
705                 710                 715                 720


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
                725                 730                 735


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
            740                 745                 750


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
        755                 760                 765


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
    770                 775                 780


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
785                 790                 795                 800


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
                805                 810                 815


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
            820                 825                 830


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
        835                 840                 845


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
    850                 855                 860


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
865                 870                 875                 880


Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser 
                885                 890                 895


Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu 
            900                 905                 910


Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln 
        915                 920                 925


Ile Lys Gln Glu Pro Asp Pro Thr Trp 
    930                 935


<210>  4930
<211>  7263
<212>  DNA
<213>  Homo sapiens

<400>  4930
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1260

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1320

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1380

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1440

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1500

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1560

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1620

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1680

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1740

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1800

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1860

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1920

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1980

gtaccactga agttactcag ccaagaacga atacaccagt caaagaagat tggaatgtca   2040

gaattaccaa gctacggaag caagtggaag agatttttaa tttgaaattt gctcaagctc   2100

ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac ccggagttct   2160

tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg tttggaattc   2220

cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg   2280

aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc   2340

agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca   2400

ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga   2460

ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga   2520

atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg   2580

aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg   2640

aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg   2700

gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa   2760

agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa   2820

aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca   2880

ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac   2940

agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg   3000

gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg   3060

atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga   3120

gaaggatctt agactctgcc gagtttatca aattcacggt cattaggtaa gtgagagttt   3180

cctgcttagt cacaggagcg aatctggagc tcatgaggct gactcttcta aaatgcagcc   3240

acaggtagtc atcgaatccg gcttcctatg ctgtgcaatc aacaaatcaa aataacttgt   3300

gtcatcatta gaatgtcaga tgtgcttcta cgaactaagc tgactctttt aattctttgg   3360

caaagggttg gcaaactagg actgtttgcc aaattcaggc tgcctcctat ttttagagtc   3420

ttcctgaaac acagctacac ccgtattatc catggctgct ttcctgtcac agtgagtaag   3480

tagctgggac tgagaaggca tggcctccaa agtctaaaat atttactctc tagcactttg   3540

tagaaaaacc ttagctaggc acagtggcta acgcctgtaa tcccagcatt ttgggaggcc   3600

aaggcaggca gatcacctga ggtcaggagt tccagaccag cctggccaac atggtgaaat   3660

cccatctcta caaaaataaa acagttagct gggcatgatg gcgggtgcct gtaatcccag   3720

ctactcggga ggctgaggca ggatagtcgc ttgaacccag gaggtggagg ttgcaatgag   3780

ccaagatcat gccactgcac tccagcctgg acgacagagt gagactccat cacaagaaaa   3840

aaagaacttt gtcaacctct gtcttagggc gccttgtcac aggcttcggg tcagacggat   3900

tcaaccttgc atcagccatt tgttagccag gtcactctgt tctttgtctg taaatgagat   3960

tgatcgttgt tcccactgag agtgtcagct ccttcccgta gagcaggcat gatgattgta   4020

ctcacctctg acaccattgt gagtgccaca ttccttccca cgtccttgtc actgtaagag   4080

atgcccacct gagcaccaac cccaggttat cttccccttt gtcttccagc cccccagaaa   4140

cagctacgac tcaacctacc caatcatttc atcatcagat tgccactgtc tctagttcag   4200

gtctcttggg actggcactc agaaatctca taataaatcc tcttgaggct tctcatacac   4260

tcgtcttctt ccaatcttct ttccctcaaa atctcatatt ttggttccac ttcacccacc   4320

gtcattctcc atatcactcc caggagttag gcaaaaagcc ccttccgttc ttccgtatgt   4380

taaacttaga atcactctgt tccctgctct gcgtttctat tttttgtttt tcctccattt   4440

actagtagct taacactttc taacagtgtt cttattattg atacgtatct atctcttcca   4500

taagcttata aggtcacgga taatacttct cattgtagta cgtaaatgac gtgggctaga   4560

tatgagttga ataaacagtt atacctgtaa attcttacag agtgaaaata aattgttata   4620

ctttacaatt tgtttctctc tttagaccat ttccaggact tgtgattaat aaccgtgagt   4680

attttgtgaa gtgttttgtt tttgtttttt cctggggtct gacgtgtgtg cgtgtgagtg   4740

tgtatacatg cttaacgtat atcacgttac ttcacctatg tcagtaacca ggccaaatac   4800

ttgttttagc cctcagtaaa aacaccaggc acttcctagt tgtaaaatta ttcaagcttc   4860

ttaacttcct atcctcgatg cacttaatca taaaatggta ataatagcac cgattttggg   4920

ggagtcgttc cagtagatgg aaagcatctg gaacaggtgt cagcaagctc ctgccgacgt   4980

gtatgcataa agttttattg aaaccaccat cgtgtccatt tgtttatggc agaactgaga   5040

gatggcagca gcaagtgtgt gcctgcaaaa cctaaaatat ttactaattg gctctgcaag   5100

aaaagagttt gcatccccct aacctagaac agtgtctagc ctctagtatg tgtttagcct   5160

acagtatgtg ctcagcgaat acaatctata tttattactg cttttatgac tgttataatt   5220

actgtgcttg gatttcgtta caaagtaagt cacaatgtgc ctgcttctgt tagtatttca   5280

gcacagtgcc tggcacacat ggggctctca aatattgctg agcgagtgaa caaatgtcct   5340

ttcaattcct taacgttgat gtcattttca atagtatttt gagccaaact taattttgcg   5400

agtgtgtttt gttttcttaa ctttattatt aaaaatgtat aaaagtgagg ccaggcgtgg   5460

tggctcacgc ctgtaatccc agcagtttgg gaggctgagg caggcggatc agttgaggtt   5520

gggagttgga gaccagcccg tccaacatgg tgaaagcctg tctctactaa aaatacaaaa   5580

atcagctggg tgtggtggcg cgtgcctgta atcccagcta ctcaggaggc tgaggcagga   5640

gagttgcttg aatcctagag gtggaggttg cagtgagctg agatcgtgcc attgcactcc   5700

agcctgggca acaagagcaa aactctgtcc caataaataa ataaataaaa tgttctcttt   5760

tgttcctgtt cttgtgcggt agtgtggtat agagttttat ggtaattact gtgaattagt   5820

gattctgagg gacatatcag aactctgagg tttgtttcct tctcatcttg agggaaacag   5880

caaatgtatg ttaaaatgct tttccaaggg aacaacacat ccttacatta tttaaaccaa   5940

tctgcttcat tttcagagct ggttgatcag agtgagtcag aaggccccgt gatacaagaa   6000

tcagctgaac caagccagtt ggaagttcca gccacagaag aaataaaaga gactgatgga   6060

agctctcaga tcaagcaaga accagacccc acgtggtaga cctcttccct cctaggctta   6120

aagtatcagt ggttgagaag agcttttcgg acctgttact accccaagct gtgtaatata   6180

cttgtataac agaaatacct tctatacaaa cctttttttc tacttttaga tagaaatgtc   6240

tactttttca gcagttctgt gaattaaaga gcagagtgac tgtgggtctg gaatggctgg   6300

tgtacttggg aatgtactat caggatttta cagcaatgct gggaaatgac agggaaaatg   6360

acaggaatga atctcaccag attttttatg tactcagcag agccttgagt tacggtgttt   6420

attttccaat caagtgaaga tatctcctac ttctcctact ggaacatctc agcttctgca   6480

gtgaagaaaa attcctgtga tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat   6540

catttaaatg atcctttgtt cacggctctc cttaatgact gagtgaacag ttcctatctg   6600

tatatttgac taaacctttt cctaagctat ctctcatggt tcctatgttt ttttatcata   6660

attaaaagca aaaccatctg gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa   6720

ttatagagga aatacagaga gaacctcttc cacttttact tttcgtccaa ataaaatgca   6780

tggtgtacca gaagttgaag atcgggttga ggattggggc tagctcgatg acactaaggc   6840

cccaacatcg cgggacctgc tgtggcgcgg attcttagga acgctgttct agccggcccc   6900

ctctccaggg gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac cctgaggtgc   6960

cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc   7020

ttcctaggag agtcttacat gtgttgagat ttcacaagca atgcgagttg taaaatacca   7080

gctctacaag aagctaggct ctgtgacggc atagttttca gtagctttat cacaatattc   7140

acaatggaga attatatgac atggtagcag aaataggccc ttttatgtgt tgcttctatt   7200

ttacctcaaa ttgtagatat agggtaatca ataaaatcca tccatgcctt tcacacacta   7260

agt                                                                 7263


<210>  4931
<211>  922
<212>  PRT
<213>  Homo sapiens

<400>  4931

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu 
            580                 585                 590


Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg 
        595                 600                 605


Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys 
    610                 615                 620


Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys 
625                 630                 635                 640


Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly 
                645                 650                 655


Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn 
            660                 665                 670


Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn 
        675                 680                 685


Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu 
    690                 695                 700


Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu 
705                 710                 715                 720


Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys 
                725                 730                 735


Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu 
            740                 745                 750


Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile 
        755                 760                 765


Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile 
    770                 775                 780


Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser 
785                 790                 795                 800


Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr 
                805                 810                 815


Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro 
            820                 825                 830


Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu 
        835                 840                 845


Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile 
    850                 855                 860


Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn 
865                 870                 875                 880


Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys 
                885                 890                 895


Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser 
            900                 905                 910


Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
        915                 920


<210>  4932
<211>  7252
<212>  DNA
<213>  Homo sapiens

<400>  4932
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1920

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct tagatttgtt   1980

gacagcggtt tcctggagtg ctgtcttgag aacgattctg aggaggctca gcaagaaaga   2040

gtgtttcagt tgattgggtg tgtctgtcat ggagaaggaa ctcaagctct tggactcacc   2100

gaggcagtaa aagtaccata tcctgtgttt gaatcaaacc cggagttctt gtatgtggaa   2160

ggcttgccag aggggattcc cttccgaagc cctacctggt ttggaattcc acgacttgaa   2220

aggatcgtcc gcgggagtaa taaaatcaag ttcgttgtta aaaaacctga actagttatt   2280

tcctacttgc ctcctgggat ggctagtaaa ataaacacta aagctttgca gtcccccaaa   2340

agaccacgaa gtcctgggag taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc   2400

cctaataaca acaatcctca aacctcagct gttcgaaccc cgacccagac taacggttct   2460

aacgttccct tcaagccacg agggagagag ttttcctttg aggcctggaa tgccaaaatc   2520

acggacctaa aacagaaagt tgaaaatctc ttcaatgaga aatgtgggga agctcttggc   2580

cttaaacaag ctgtgaaggt gccgttcgcg ttatttgagt ctttcccgga agacttttat   2640

gtggaaggct tacctgaggg tgtgccattc cgaagaccat cgacttttgg cattccgagg   2700

ctggagaaga tactcagaaa caaagccaaa attaagttca tcattaaaaa gcccgaaatg   2760

tttgagacgg cgattaagga gagcacctcc tctaagagcc ctcccagaaa aataaattca   2820

tcacccaatg ttaatactac tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca   2880

attccagatg atgataatga aagactctcg aaagttgaaa aagctagaca gctaagagaa   2940

caagtgaatg acctctttag tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg   3000

aaagttccct acaggaaaat cacaattaac cctggctgtg tggtggttga tggcatgccc   3060

ccgggggtgt ccttcaaagc ccccagctac ctggaaatca gctccatgag aaggatctta   3120

gactctgccg agtttatcaa attcacggtc attaggtaag tgagagtttc ctgcttagtc   3180

acaggagcga atctggagct catgaggctg actcttctaa aatgcagcca caggtagtca   3240

tcgaatccgg cttcctatgc tgtgcaatca acaaatcaaa ataacttgtg tcatcattag   3300

aatgtcagat gtgcttctac gaactaagct gactctttta attctttggc aaagggttgg   3360

caaactagga ctgtttgcca aattcaggct gcctcctatt tttagagtct tcctgaaaca   3420

cagctacacc cgtattatcc atggctgctt tcctgtcaca gtgagtaagt agctgggact   3480

gagaaggcat ggcctccaaa gtctaaaata tttactctct agcactttgt agaaaaacct   3540

tagctaggca cagtggctaa cgcctgtaat cccagcattt tgggaggcca aggcaggcag   3600

atcacctgag gtcaggagtt ccagaccagc ctggccaaca tggtgaaatc ccatctctac   3660

aaaaataaaa cagttagctg ggcatgatgg cgggtgcctg taatcccagc tactcgggag   3720

gctgaggcag gatagtcgct tgaacccagg aggtggaggt tgcaatgagc caagatcatg   3780

ccactgcact ccagcctgga cgacagagtg agactccatc acaagaaaaa aagaactttg   3840

tcaacctctg tcttagggcg ccttgtcaca ggcttcgggt cagacggatt caaccttgca   3900

tcagccattt gttagccagg tcactctgtt ctttgtctgt aaatgagatt gatcgttgtt   3960

cccactgaga gtgtcagctc cttcccgtag agcaggcatg atgattgtac tcacctctga   4020

caccattgtg agtgccacat tccttcccac gtccttgtca ctgtaagaga tgcccacctg   4080

agcaccaacc ccaggttatc ttcccctttg tcttccagcc ccccagaaac agctacgact   4140

caacctaccc aatcatttca tcatcagatt gccactgtct ctagttcagg tctcttggga   4200

ctggcactca gaaatctcat aataaatcct cttgaggctt ctcatacact cgtcttcttc   4260

caatcttctt tccctcaaaa tctcatattt tggttccact tcacccaccg tcattctcca   4320

tatcactccc aggagttagg caaaaagccc cttccgttct tccgtatgtt aaacttagaa   4380

tcactctgtt ccctgctctg cgtttctatt ttttgttttt cctccattta ctagtagctt   4440

aacactttct aacagtgttc ttattattga tacgtatcta tctcttccat aagcttataa   4500

ggtcacggat aatacttctc attgtagtac gtaaatgacg tgggctagat atgagttgaa   4560

taaacagtta tacctgtaaa ttcttacaga gtgaaaataa attgttatac tttacaattt   4620

gtttctctct ttagaccatt tccaggactt gtgattaata accgtgagta ttttgtgaag   4680

tgttttgttt ttgttttttc ctggggtctg acgtgtgtgc gtgtgagtgt gtatacatgc   4740

ttaacgtata tcacgttact tcacctatgt cagtaaccag gccaaatact tgttttagcc   4800

ctcagtaaaa acaccaggca cttcctagtt gtaaaattat tcaagcttct taacttccta   4860

tcctcgatgc acttaatcat aaaatggtaa taatagcacc gattttgggg gagtcgttcc   4920

agtagatgga aagcatctgg aacaggtgtc agcaagctcc tgccgacgtg tatgcataaa   4980

gttttattga aaccaccatc gtgtccattt gtttatggca gaactgagag atggcagcag   5040

caagtgtgtg cctgcaaaac ctaaaatatt tactaattgg ctctgcaaga aaagagtttg   5100

catcccccta acctagaaca gtgtctagcc tctagtatgt gtttagccta cagtatgtgc   5160

tcagcgaata caatctatat ttattactgc ttttatgact gttataatta ctgtgcttgg   5220

atttcgttac aaagtaagtc acaatgtgcc tgcttctgtt agtatttcag cacagtgcct   5280

ggcacacatg gggctctcaa atattgctga gcgagtgaac aaatgtcctt tcaattcctt   5340

aacgttgatg tcattttcaa tagtattttg agccaaactt aattttgcga gtgtgttttg   5400

ttttcttaac tttattatta aaaatgtata aaagtgaggc caggcgtggt ggctcacgcc   5460

tgtaatccca gcagtttggg aggctgaggc aggcggatca gttgaggttg ggagttggag   5520

accagcccgt ccaacatggt gaaagcctgt ctctactaaa aatacaaaaa tcagctgggt   5580

gtggtggcgc gtgcctgtaa tcccagctac tcaggaggct gaggcaggag agttgcttga   5640

atcctagagg tggaggttgc agtgagctga gatcgtgcca ttgcactcca gcctgggcaa   5700

caagagcaaa actctgtccc aataaataaa taaataaaat gttctctttt gttcctgttc   5760

ttgtgcggta gtgtggtata gagttttatg gtaattactg tgaattagtg attctgaggg   5820

acatatcaga actctgaggt ttgtttcctt ctcatcttga gggaaacagc aaatgtatgt   5880

taaaatgctt ttccaaggga acaacacatc cttacattat ttaaaccaat ctgcttcatt   5940

ttcagagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat cagctgaacc   6000

aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa gctctcagat   6060

caagcaagaa ccagacccca cgtggtagac ctcttccctc ctaggcttaa agtatcagtg   6120

gttgagaaga gcttttcgga cctgttacta ccccaagctg tgtaatatac ttgtataaca   6180

gaaatacctt ctatacaaac ctttttttct acttttagat agaaatgtct actttttcag   6240

cagttctgtg aattaaagag cagagtgact gtgggtctgg aatggctggt gtacttggga   6300

atgtactatc aggattttac agcaatgctg ggaaatgaca gggaaaatga caggaatgaa   6360

tctcaccaga ttttttatgt actcagcaga gccttgagtt acggtgttta ttttccaatc   6420

aagtgaagat atctcctact tctcctactg gaacatctca gcttctgcag tgaagaaaaa   6480

ttcctgtgat agttcagttc tttagttttt ctatttgaaa aaaaaaaatc atttaaatga   6540

tcctttgttc acggctctcc ttaatgactg agtgaacagt tcctatctgt atatttgact   6600

aaaccttttc ctaagctatc tctcatggtt cctatgtttt tttatcataa ttaaaagcaa   6660

aaccatctgg atcacctaac agtcagaggt cagtatctca gcgtgtgaat tatagaggaa   6720

atacagagag aacctcttcc acttttactt ttcgtccaaa taaaatgcat ggtgtaccag   6780

aagttgaaga tcgggttgag gattggggct agctcgatga cactaaggcc ccaacatcgc   6840

gggacctgct gtggcgcgga ttcttaggaa cgctgttcta gccggccccc tctccagggg   6900

tcgccgtggc cggcattatt tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga   6960

gtgaggaggg gtcagggggc taaggatgca acctctgacg ttctgcgcct tcctaggaga   7020

gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt aaaataccag ctctacaaga   7080

agctaggctc tgtgacggca tagttttcag tagctttatc acaatattca caatggagaa   7140

ttatatgaca tggtagcaga aataggccct tttatgtgtt gcttctattt tacctcaaat   7200

tgtagatata gggtaatcaa taaaatccat ccatgccttt cacacactaa gt           7252


<210>  4933
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  4933

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
            500                 505                 510


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
        515                 520


<210>  4934
<211>  3755
<212>  DNA
<213>  Homo sapiens

<400>  4934
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagctca agctcttgga ctcaccgagg   1920

cagtaaaagt accatatcct gtgtttgaat caaacccgga gttcttgtat gtggaaggct   1980

tgccagaggg gattcccttc cgaagcccta cctggtttgg aattccacga cttgaaagga   2040

tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa acctgaacta gttatttcct   2100

acttgcctcc tgggatggct agtaaaataa acactaaagc tttgcagtcc cccaaaagac   2160

cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta   2220

ataacaacaa tcctcaaacc tcagctgttc gaaccccgac ccagactaac ggttctaacg   2280

ttcccttcaa gccacgaggg agagagtttt cctttgaggc ctggaatgcc aaaatcacgg   2340

acctaaaaca gaaagttgaa aatctcttca atgagaaatg tggggaagct cttggcctta   2400

aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg   2460

aaggcttacc tgagggtgtg ccattccgaa gaccatcgac ttttggcatt ccgaggctgg   2520

agaagatact cagaaacaaa gccaaaatta agttcatcat taaaaagccc gaaatgtttg   2580

agacggcgat taaggagagc acctcctcta agagccctcc cagaaaaata aattcatcac   2640

ccaatgttaa tactactgca tcaggtgttg aagaccttaa catcattcag gtgacaattc   2700

cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc tagacagcta agagaacaag   2760

tgaatgacct ctttagtcgg aaatttggtg aagctattgg tatgggtttt cctgtgaaag   2820

ttccctacag gaaaatcaca attaaccctg gctgtgtggt ggttgatggc atgcccccgg   2880

gggtgtcctt caaagccccc agctacctgg aaatcagctc catgagaagg atcttagact   2940

ctgccgagtt tatcaaattc acggtcatta gaccatttcc aggacttgtg attaataacc   3000

agctggttga tcagagtgag tcagaaggcc ccgtgataca agaatcagct gaaccaagcc   3060

agttggaagt tccagccaca gaagaaataa aagagactga tggaagctct cagatcaagc   3120

aagaaccaga ccccacgtgg tagacctctt ccctcctagg caaaaccatc tggatcacct   3180

aacagtcaga ggtcagtatc tcagcgtgtg aattatagag gaaatacaga gagaacctct   3240

tccactttta cttttcgtcc aaataaaatg catggtgtac cagaagttga agatcgggtt   3300

gaggattggg gctagctcga tgacactaag gccccaacat cgcgggacct gctgtggcgc   3360

ggattcttag gaacgctgtt ctagccggcc ccctctccag gggtcgccgt ggccggcatt   3420

atttcctagt tcttcttgta accctgaggt gccagcgcgg ggagtgagga ggggtcaggg   3480

ggctaaggat gcaacctctg acgttctgcg ccttcctagg agagtcttac atgtgttgag   3540

atttcacaag caatgcgagt tgtaaaatac cagctctaca agaagctagg ctctgtgacg   3600

gcatagtttt cagtagcttt atcacaatat tcacaatgga gaattatatg acatggtagc   3660

agaaataggc ccttttatgt gttgcttcta ttttacctca aattgtagat atagggtaat   3720

caataaaatc catccatgcc tttcacacac taagt                              3755


<210>  4935
<211>  913
<212>  PRT
<213>  Homo sapiens

<400>  4935

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
            500                 505                 510


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
        515                 520                 525


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
    530                 535                 540


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
545                 550                 555                 560


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
                565                 570                 575


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
            580                 585                 590


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
        595                 600                 605


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
    610                 615                 620


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
625                 630                 635                 640


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
                645                 650                 655


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
            660                 665                 670


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
        675                 680                 685


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
    690                 695                 700


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
705                 710                 715                 720


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
                725                 730                 735


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
            740                 745                 750


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
        755                 760                 765


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
    770                 775                 780


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
785                 790                 795                 800


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
                805                 810                 815


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
            820                 825                 830


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
        835                 840                 845


Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile 
    850                 855                 860


Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln 
865                 870                 875                 880


Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile 
                885                 890                 895


Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr 
            900                 905                 910


Trp 



<210>  4936
<211>  4348
<212>  DNA
<213>  Homo sapiens

<400>  4936
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1140

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1200

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1260

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1320

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1380

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1440

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1500

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1560

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1620

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1680

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1740

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1800

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1860

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1920

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1980

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   2040

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   2100

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2160

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2220

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2280

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2340

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2400

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2460

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2520

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2580

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2640

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2700

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2760

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2820

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2880

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2940

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   3000

cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg atcagagtga   3060

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   3120

agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag accccacgtg   3180

gtagacctct tccctcctag gcttaaagta tcagtggttg agaagagctt ttcggacctg   3240

ttactacccc aagctgtgta atatacttgt ataacagaaa taccttctat acaaaccttt   3300

ttttctactt ttagatagaa atgtctactt tttcagcagt tctgtgaatt aaagagcaga   3360

gtgactgtgg gtctggaatg gctggtgtac ttgggaatgt actatcagga ttttacagca   3420

atgctgggaa atgacaggga aaatgacagg aatgaatctc accagatttt ttatgtactc   3480

agcagagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct cctacttctc   3540

ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta   3600

gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg ctctccttaa   3660

tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa gctatctctc   3720

atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca cctaacagtc   3780

agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc tcttccactt   3840

ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg gttgaggatt   3900

ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg cgcggattct   3960

taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc attatttcct   4020

agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca gggggctaag   4080

gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt gagatttcac   4140

aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg acggcatagt   4200

tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt agcagaaata   4260

ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt aatcaataaa   4320

atccatccat gcctttcaca cactaagt                                      4348


<210>  4937
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  4937

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr Asp Asp Val Asp Glu 
                165                 170                 175


Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser His His Ser Ser Glu 
            180                 185                 190


Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr 
        195                 200                 205


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
    210                 215                 220


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
225                 230                 235                 240


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
                245                 250                 255


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
            260                 265                 270


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
        275                 280                 285


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
    290                 295                 300


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
305                 310                 315                 320


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
                325                 330                 335


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
            340                 345                 350


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
        355                 360                 365


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
    370                 375                 380


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
385                 390                 395                 400


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
                405                 410                 415


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
            420                 425                 430


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
        435                 440                 445


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
    450                 455                 460


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
465                 470                 475                 480


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
                485                 490                 495


Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys 
            500                 505                 510


Asn Leu Asn 
        515


<210>  4938
<211>  4406
<212>  DNA
<213>  Homo sapiens

<400>  4938
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2040

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2100

tttgaaattt gcttagattt gttgacagcg gtttcctgga gtgctgtctt gagaacgatt   2160

ctgaggaggc tcagcaagaa agagtgtttc agttgattgg gtgtgtctgt catggagaag   2220

gaactcaagc tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa   2280

acccggagtt cttgtatgtg gaaggcttgc cagaggggat tcccttccga agccctacct   2340

ggtttggaat tccacgactt gaaaggatcg tccgcgggag taataaaatc aagttcgttg   2400

ttaaaaaacc tgaactagtt atttcctact tgcctcctgg gatggctagt aaaataaaca   2460

ctaaagcttt gcagtccccc aaaagaccac gaagtcctgg gagtaattca aaggttcctg   2520

aaattgaggt caccgtggaa ggccctaata acaacaatcc tcaaacctca gctgttcgaa   2580

ccccgaccca gactaacggt tctaacgttc ccttcaagcc acgagggaga gagttttcct   2640

ttgaggcctg gaatgccaaa atcacggacc taaaacagaa agttgaaaat ctcttcaatg   2700

agaaatgtgg ggaagctctt ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg   2760

agtctttccc ggaagacttt tatgtggaag gcttacctga gggtgtgcca ttccgaagac   2820

catcgacttt tggcattccg aggctggaga agatactcag aaacaaagcc aaaattaagt   2880

tcatcattaa aaagcccgaa atgtttgaga cggcgattaa ggagagcacc tcctctaaga   2940

gccctcccag aaaaataaat tcatcaccca atgttaatac tactgcatca ggtgttgaag   3000

accttaacat cattcaggtg acaattccag atgatgataa tgaaagactc tcgaaagttg   3060

aaaaagctag acagctaaga gaacaagtga atgacctctt tagtcggaaa tttggtgaag   3120

ctattggtat gggttttcct gtgaaagttc cctacaggaa aatcacaatt aaccctggct   3180

gtgtggtggt tgatggcatg cccccggggg tgtccttcaa agcccccagc tacctggaaa   3240

tcagctccat gagaaggatc ttagactctg ccgagtttat caaattcacg gtcattagac   3300

catttccagg acttgtgatt aataaccagc tggttgatca gagtgagtca gaaggccccg   3360

tgatacaaga atcagctgaa ccaagccagt tggaagttcc agccacagaa gaaataaaag   3420

agactgatgg aagctctcag atcaagcaag aaccagaccc cacgtggtag acctcttccc   3480

tcctaggctt aaagtatcag tggttgagaa gagcttttcg gacctgttac taccccaagc   3540

tgtagccttg agttacggtg tttattttcc aatcaagtga agatatctcc tacttctcct   3600

actggaacat ctcagcttct gcagtgaaga aaaattcctg tgatagttca gttctttagt   3660

ttttctattt gaaaaaaaaa aatcatttaa atgatccttt gttcacggct ctccttaatg   3720

actgagtgaa cagttcctat ctgtatattt gactaaacct tttcctaagc tatctctcat   3780

ggttcctatg tttttttatc ataattaaaa gcaaaaccat ctggatcacc taacagtcag   3840

aggtcagtat ctcagcgtgt gaattataga ggaaatacag agagaacctc ttccactttt   3900

acttttcgtc caaataaaat gcatggtgta ccagaagttg aagatcgggt tgaggattgg   3960

ggctagctcg atgacactaa ggccccaaca tcgcgggacc tgctgtggcg cggattctta   4020

ggaacgctgt tctagccggc cccctctcca ggggtcgccg tggccggcat tatttcctag   4080

ttcttcttgt aaccctgagg tgccagcgcg gggagtgagg aggggtcagg gggctaagga   4140

tgcaacctct gacgttctgc gccttcctag gagagtctta catgtgttga gatttcacaa   4200

gcaatgcgag ttgtaaaata ccagctctac aagaagctag gctctgtgac ggcatagttt   4260

tcagtagctt tatcacaata ttcacaatgg agaattatat gacatggtag cagaaatagg   4320

cccttttatg tgttgcttct attttacctc aaattgtaga tatagggtaa tcaataaaat   4380

ccatccatgc ctttcacaca ctaagt                                        4406


<210>  4939
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  4939

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala 



<210>  4940
<211>  4981
<212>  DNA
<213>  Homo sapiens

<400>  4940
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1860

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1920

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1980

aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc   2040

ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt   2100

tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa   2160

taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg   2220

ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg   2280

ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga gggagagagt   2340

tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct   2400

tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt   2460

tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc   2520

gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa   2580

ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct   2640

ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg   2700

ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga   2760

aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg   2820

gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc   2880

ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc   2940

tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca   3000

ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt gagtcagaag   3060

gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc acagaaggta   3120

aaaggacctc ttccctccta gggtaaatca gcttctgtgt cagggatgct gtgtggtgtc   3180

catctgaacc ccctgcatac gcgtagctaa tgtgatctcc ccactttcac ataagatggt   3240

ggccctgcct tcagggaatg tgggagccag gtgggagcct tcccggatat ttaagctaga   3300

agattctaca gggagattct ccttggatca atatatgtct ctcagtcaaa gatgtaaaag   3360

cacttttgcc ttaaaaagaa tgttctgttt ctaaatagag tcaacgttgt cctcctcatt   3420

ggaattcact atgagtcaga atcattagac tgactttttt ttttccatag taatagtatt   3480

ttgcagagtc tcacagagct gcagatcttt tgttcatctt gcagagttaa caagtctgat   3540

cctgttagtc cagatttctt aaatttggcc aagttataat aggagcagta gcttgagacc   3600

cgaagtcagg aaactttgac aatggatttt tttttttaat ccagagactt gtactggaat   3660

ttgccttacc ctgtcagctc atggacttaa ggtttcatcc cgctttatga gtgcttctga   3720

atccaagtca ttgttacctg aatttgcaaa ttaagttgtg atattcgtga ctgttaaatt   3780

cctgtaatta gattaacctc tttgcttgct tgtttgtttt ctctcctatt ttagcttaaa   3840

gtatcagtgg ttgagaagag cttttcggac ctgttactac cccaagctgt gtaatatact   3900

tgtataacag aaataccttc tatacaaacc tttttttcta cttttagata gaaatgtcta   3960

ctttttcagc agttctgtga attaaagagc agagtgactg tgggtctgga atggctggtg   4020

tacttgggaa tgtactatca ggattttaca gcaatgctgg gaaatgacag ggaaaatgac   4080

aggaatgaat ctcaccagat tttttatgta ctcagcagag ccttgagtta cggtgtttat   4140

tttccaatca agtgaagata tctcctactt ctcctactgg aacatctcag cttctgcagt   4200

gaagaaaaat tcctgtgata gttcagttct ttagtttttc tatttgaaaa aaaaaaatca   4260

tttaaatgat cctttgttca cggctctcct taatgactga gtgaacagtt cctatctgta   4320

tatttgacta aaccttttcc taagctatct ctcatggttc ctatgttttt ttatcataat   4380

taaaagcaaa accatctgga tcacctaaca gtcagaggtc agtatctcag cgtgtgaatt   4440

atagaggaaa tacagagaga acctcttcca cttttacttt tcgtccaaat aaaatgcatg   4500

gtgtaccaga agttgaagat cgggttgagg attggggcta gctcgatgac actaaggccc   4560

caacatcgcg ggacctgctg tggcgcggat tcttaggaac gctgttctag ccggccccct   4620

ctccaggggt cgccgtggcc ggcattattt cctagttctt cttgtaaccc tgaggtgcca   4680

gcgcggggag tgaggagggg tcagggggct aaggatgcaa cctctgacgt tctgcgcctt   4740

cctaggagag tcttacatgt gttgagattt cacaagcaat gcgagttgta aaataccagc   4800

tctacaagaa gctaggctct gtgacggcat agttttcagt agctttatca caatattcac   4860

aatggagaat tatatgacat ggtagcagaa ataggccctt ttatgtgttg cttctatttt   4920

acctcaaatt gtagatatag ggtaatcaat aaaatccatc catgcctttc acacactaag   4980

t                                                                   4981


<210>  4941
<211>  853
<212>  PRT
<213>  Homo sapiens

<400>  4941

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg 
            420                 425                 430


Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe 
        435                 440                 445


Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val 
    450                 455                 460


Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly 
465                 470                 475                 480


Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg 
                485                 490                 495


Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu 
            500                 505                 510


Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr 
        515                 520                 525


Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser 
    530                 535                 540


Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn 
545                 550                 555                 560


Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn 
                565                 570                 575


Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn 
            580                 585                 590


Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu 
        595                 600                 605


Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe 
    610                 615                 620


Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro 
625                 630                 635                 640


Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu 
                645                 650                 655


Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys 
            660                 665                 670


Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser 
        675                 680                 685


Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser 
    690                 695                 700


Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp 
705                 710                 715                 720


Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln 
                725                 730                 735


Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly 
            740                 745                 750


Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys 
        755                 760                 765


Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser 
    770                 775                 780


Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe 
785                 790                 795                 800


Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn 
                805                 810                 815


Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser 
            820                 825                 830


Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Gly Lys Arg Thr 
        835                 840                 845


Ser Ser Leu Leu Gly 
    850


<210>  4942
<211>  7912
<212>  DNA
<213>  Homo sapiens

<400>  4942
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   1980

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2040

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2100

atcaaacccg gagttcttgt atgtggaagg cttgccagag gggattccct tccgaagccc   2160

tacctggttt ggaattccac gacttgaaag gatcgtccgc gggagtaata aaatcaagtt   2220

cgttgttaaa aaacctgaac tagttatttc ctacttgcct cctgggatgg ctagtaaaat   2280

aaacactaaa gctttgcagt cccccaaaag accacgaagt cctgggagta attcaaaggt   2340

tcctgaaatt gaggtcaccg tggaaggccc taataacaac aatcctcaaa cctcagctgt   2400

tcgaaccccg acccagacta acggttctaa cgttcccttc aagccacgag ggagagagtt   2460

ttcctttgag gcctggaatg ccaaaatcac ggacctaaaa cagaaagttg aaaatctctt   2520

caatgagaaa tgtggggaag ctcttggcct taaacaagct gtgaaggtgc cgttcgcgtt   2580

atttgagtct ttcccggaag acttttatgt ggaaggctta cctgagggtg tgccattccg   2640

aagaccatcg acttttggca ttccgaggct ggagaagata ctcagaaaca aagccaaaat   2700

taagttcatc attaaaaagc ccgaaatgtt tgagacggcg attaaggaga gcacctcctc   2760

taagagccct cccagaaaaa taaattcatc acccaatgtt aatactactg catcaggtgt   2820

tgaagacctt aacatcattc aggtgacaat tccagatgat gataatgaaa gactctcgaa   2880

agttgaaaaa gctagacagc taagagaaca agtgaatgac ctctttagtc ggaaatttgg   2940

tgaagctatt ggtatgggtt ttcctgtgaa agttccctac aggaaaatca caattaaccc   3000

tggctgtgtg gtggttgatg gcatgccccc gggggtgtcc ttcaaagccc ccagctacct   3060

ggaaatcagc tccatgagaa ggatcttaga ctctgccgag tttatcaaat tcacggtcat   3120

taggtaagtg agagtttcct gcttagtcac aggagcgaat ctggagctca tgaggctgac   3180

tcttctaaaa tgcagccaca ggtagtcatc gaatccggct tcctatgctg tgcaatcaac   3240

aaatcaaaat aacttgtgtc atcattagaa tgtcagatgt gcttctacga actaagctga   3300

ctcttttaat tctttggcaa agggttggca aactaggact gtttgccaaa ttcaggctgc   3360

ctcctatttt tagagtcttc ctgaaacaca gctacacccg tattatccat ggctgctttc   3420

ctgtcacagt gagtaagtag ctgggactga gaaggcatgg cctccaaagt ctaaaatatt   3480

tactctctag cactttgtag aaaaacctta gctaggcaca gtggctaacg cctgtaatcc   3540

cagcattttg ggaggccaag gcaggcagat cacctgaggt caggagttcc agaccagcct   3600

ggccaacatg gtgaaatccc atctctacaa aaataaaaca gttagctggg catgatggcg   3660

ggtgcctgta atcccagcta ctcgggaggc tgaggcagga tagtcgcttg aacccaggag   3720

gtggaggttg caatgagcca agatcatgcc actgcactcc agcctggacg acagagtgag   3780

actccatcac aagaaaaaaa gaactttgtc aacctctgtc ttagggcgcc ttgtcacagg   3840

cttcgggtca gacggattca accttgcatc agccatttgt tagccaggtc actctgttct   3900

ttgtctgtaa atgagattga tcgttgttcc cactgagagt gtcagctcct tcccgtagag   3960

caggcatgat gattgtactc acctctgaca ccattgtgag tgccacattc cttcccacgt   4020

ccttgtcact gtaagagatg cccacctgag caccaacccc aggttatctt cccctttgtc   4080

ttccagcccc ccagaaacag ctacgactca acctacccaa tcatttcatc atcagattgc   4140

cactgtctct agttcaggtc tcttgggact ggcactcaga aatctcataa taaatcctct   4200

tgaggcttct catacactcg tcttcttcca atcttctttc cctcaaaatc tcatattttg   4260

gttccacttc acccaccgtc attctccata tcactcccag gagttaggca aaaagcccct   4320

tccgttcttc cgtatgttaa acttagaatc actctgttcc ctgctctgcg tttctatttt   4380

ttgtttttcc tccatttact agtagcttaa cactttctaa cagtgttctt attattgata   4440

cgtatctatc tcttccataa gcttataagg tcacggataa tacttctcat tgtagtacgt   4500

aaatgacgtg ggctagatat gagttgaata aacagttata cctgtaaatt cttacagagt   4560

gaaaataaat tgttatactt tacaatttgt ttctctcttt agaccatttc caggacttgt   4620

gattaataac cgtgagtatt ttgtgaagtg ttttgttttt gttttttcct ggggtctgac   4680

gtgtgtgcgt gtgagtgtgt atacatgctt aacgtatatc acgttacttc acctatgtca   4740

gtaaccaggc caaatacttg ttttagccct cagtaaaaac accaggcact tcctagttgt   4800

aaaattattc aagcttctta acttcctatc ctcgatgcac ttaatcataa aatggtaata   4860

atagcaccga ttttggggga gtcgttccag tagatggaaa gcatctggaa caggtgtcag   4920

caagctcctg ccgacgtgta tgcataaagt tttattgaaa ccaccatcgt gtccatttgt   4980

ttatggcaga actgagagat ggcagcagca agtgtgtgcc tgcaaaacct aaaatattta   5040

ctaattggct ctgcaagaaa agagtttgca tccccctaac ctagaacagt gtctagcctc   5100

tagtatgtgt ttagcctaca gtatgtgctc agcgaataca atctatattt attactgctt   5160

ttatgactgt tataattact gtgcttggat ttcgttacaa agtaagtcac aatgtgcctg   5220

cttctgttag tatttcagca cagtgcctgg cacacatggg gctctcaaat attgctgagc   5280

gagtgaacaa atgtcctttc aattccttaa cgttgatgtc attttcaata gtattttgag   5340

ccaaacttaa ttttgcgagt gtgttttgtt ttcttaactt tattattaaa aatgtataaa   5400

agtgaggcca ggcgtggtgg ctcacgcctg taatcccagc agtttgggag gctgaggcag   5460

gcggatcagt tgaggttggg agttggagac cagcccgtcc aacatggtga aagcctgtct   5520

ctactaaaaa tacaaaaatc agctgggtgt ggtggcgcgt gcctgtaatc ccagctactc   5580

aggaggctga ggcaggagag ttgcttgaat cctagaggtg gaggttgcag tgagctgaga   5640

tcgtgccatt gcactccagc ctgggcaaca agagcaaaac tctgtcccaa taaataaata   5700

aataaaatgt tctcttttgt tcctgttctt gtgcggtagt gtggtataga gttttatggt   5760

aattactgtg aattagtgat tctgagggac atatcagaac tctgaggttt gtttccttct   5820

catcttgagg gaaacagcaa atgtatgtta aaatgctttt ccaagggaac aacacatcct   5880

tacattattt aaaccaatct gcttcatttt cagagctggt tgatcagagt gagtcagaag   5940

gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc acagaagaaa   6000

taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg tggtagacct   6060

cttccctcct agggtaaatc agcttctgtg tcagggatgc tgtgtggtgt ccatctgaac   6120

cccctgcata cgcgtagcta atgtgatctc cccactttca cataagatgg tggccctgcc   6180

ttcagggaat gtgggagcca ggtgggagcc ttcccggata tttaagctag aagattctac   6240

agggagattc tccttggatc aatatatgtc tctcagtcaa agatgtaaaa gcacttttgc   6300

cttaaaaaga atgttctgtt tctaaataga gtcaacgttg tcctcctcat tggaattcac   6360

tatgagtcag aatcattaga ctgacttttt tttttccata gtaatagtat tttgcagagt   6420

ctcacagagc tgcagatctt ttgttcatct tgcagagtta acaagtctga tcctgttagt   6480

ccagatttct taaatttggc caagttataa taggagcagt agcttgagac ccgaagtcag   6540

gaaactttga caatggattt ttttttttaa tccagagact tgtactggaa tttgccttac   6600

cctgtcagct catggactta aggtttcatc ccgctttatg agtgcttctg aatccaagtc   6660

attgttacct gaatttgcaa attaagttgt gatattcgtg actgttaaat tcctgtaatt   6720

agattaacct ctttgcttgc ttgtttgttt tctctcctat tttagcttaa agtatcagtg   6780

gttgagaaga gcttttcgga cctgttacta ccccaagctg tgtaatatac ttgtataaca   6840

gaaatacctt ctatacaaac ctttttttct acttttagat agaaatgtct actttttcag   6900

cagttctgtg aattaaagag cagagtgact gtgggtctgg aatggctggt gtacttggga   6960

atgtactatc aggattttac agcaatgctg ggaaatgaca gggaaaatga caggaatgaa   7020

tctcaccaga ttttttatgt actcagcaga gccttgagtt acggtgttta ttttccaatc   7080

aagtgaagat atctcctact tctcctactg gaacatctca gcttctgcag tgaagaaaaa   7140

ttcctgtgat agttcagttc tttagttttt ctatttgaaa aaaaaaaatc atttaaatga   7200

tcctttgttc acggctctcc ttaatgactg agtgaacagt tcctatctgt atatttgact   7260

aaaccttttc ctaagctatc tctcatggtt cctatgtttt tttatcataa ttaaaagcaa   7320

aaccatctgg atcacctaac agtcagaggt cagtatctca gcgtgtgaat tatagaggaa   7380

atacagagag aacctcttcc acttttactt ttcgtccaaa taaaatgcat ggtgtaccag   7440

aagttgaaga tcgggttgag gattggggct agctcgatga cactaaggcc ccaacatcgc   7500

gggacctgct gtggcgcgga ttcttaggaa cgctgttcta gccggccccc tctccagggg   7560

tcgccgtggc cggcattatt tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga   7620

gtgaggaggg gtcagggggc taaggatgca acctctgacg ttctgcgcct tcctaggaga   7680

gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt aaaataccag ctctacaaga   7740

agctaggctc tgtgacggca tagttttcag tagctttatc acaatattca caatggagaa   7800

ttatatgaca tggtagcaga aataggccct tttatgtgtt gcttctattt tacctcaaat   7860

tgtagatata gggtaatcaa taaaatccat ccatgccttt cacacactaa gt           7912


<210>  4943
<211>  901
<212>  PRT
<213>  Homo sapiens

<400>  4943

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
                565                 570                 575


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
            580                 585                 590


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
        595                 600                 605


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
    610                 615                 620


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
625                 630                 635                 640


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
                645                 650                 655


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
            660                 665                 670


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
        675                 680                 685


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
    690                 695                 700


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
705                 710                 715                 720


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
                725                 730                 735


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
            740                 745                 750


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
        755                 760                 765


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
    770                 775                 780


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
785                 790                 795                 800


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
                805                 810                 815


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
            820                 825                 830


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
        835                 840                 845


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
    850                 855                 860


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
865                 870                 875                 880


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
                885                 890                 895


Phe Thr Val Ile Arg 
            900


<210>  4944
<211>  5062
<212>  DNA
<213>  Homo sapiens

<400>  4944
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gattctactc aacatgtccc ttcagaaaca agtgaggacc   1200

ctgaagttga ggtgactatt gaagatgatg attattctcc accgtctaag agaccaaagg   1260

ccaatgagct accgcagcca ccagtcccgg aacccgccaa tgctgggaag cggaaagtga   1320

gggagttcaa cttcgagaaa tggaatgctc gcatcactga tctacgtaaa caagttgaag   1380

aattgtttga aaggaaatat gctcaagcca taaaagccaa aggtccggtg acgatcccgt   1440

accctctttt ccagtctcat gttgaagatc tttatgtaga aggacttcct gaaggaattc   1500

cttttagaag gccatctact tacggaattc ctcgcctgga gaggatatta cttgcaaagg   1560

aaaggattcg ttttgtgatt aagaaacatg agcttctgaa ttcaacacgt gaagatttac   1620

agcttgataa gccagcttca ggagtaaagg aagaatggta tgccagaatc actaaattaa   1680

gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga agccttgggg agcactgaag   1740

ccaaggctgt accgtaccaa aaatttgagg cacacccgaa tgatctgtac gtggaaggac   1800

tgccagaaaa cattcctttc cgaagtccct catggtatgg aatcccaagg ctggaaaaaa   1860

tcattcaagt gggcaatcga attaaatttg ttattaaaag accagaactt ctgactcaca   1920

gtaccactga agttactcag ccaagaacga atacaccagc tcaagctctt ggactcaccg   1980

aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag   2040

gcttgccaga ggggattccc ttccgaagcc ctacctggtt tggaattcca cgacttgaaa   2100

ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt   2160

cctacttgcc tcctgggatg gctagtaaaa taaacactaa agctttgcag tcccccaaaa   2220

gaccacgaag tcctgggagt aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc   2280

ctaataacaa caatcctcaa acctcagctg ttcgaacccc gacccagact aacggttcta   2340

acgttccctt caagccacga gggagagagt tttcctttga ggcctggaat gccaaaatca   2400

cggacctaaa acagaaagtt gaaaatctct tcaatgagaa atgtggggaa gctcttggcc   2460

ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc tttcccggaa gacttttatg   2520

tggaaggctt acctgagggt gtgccattcc gaagaccatc gacttttggc attccgaggc   2580

tggagaagat actcagaaac aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt   2640

ttgagacggc gattaaggag agcacctcct ctaagagccc tcccagaaaa ataaattcat   2700

cacccaatgt taatactact gcatcaggtg ttgaagacct taacatcatt caggtgacaa   2760

ttccagatga tgataatgaa agactctcga aagttgaaaa agctagacag ctaagagaac   2820

aagtgaatga cctctttagt cggaaatttg gtgaagctat tggtatgggt tttcctgtga   2880

aagttcccta caggaaaatc acaattaacc ctggctgtgt ggtggttgat ggcatgcccc   2940

cgggggtgtc cttcaaagcc cccagctacc tggaaatcag ctccatgaga aggatcttag   3000

actctgccga gtttatcaaa ttcacggtca ttagaccatt tccaggactt gtgattaata   3060

accagctggt tgatcagagt gagtcagaag gccccgtgat acaagaatca gctgaaccaa   3120

gccagttgga agttccagcc acagaagaaa taaaagagac tgatggaagc tctcagatca   3180

agcaagaacc agaccccacg tggtagacct cttccctcct agggtaaatc agcttctgtg   3240

tcagggatgc tgtgtggtgt ccatctgaac cccctgcata cgcgtagcta atgtgatctc   3300

cccactttca cataagatgg tggccctgcc ttcagggaat gtgggagcca ggtgggagcc   3360

ttcccggata tttaagctag aagattctac agggagattc tccttggatc aatatatgtc   3420

tctcagtcaa agatgtaaaa gcacttttgc cttaaaaaga atgttctgtt tctaaataga   3480

gtcaacgttg tcctcctcat tggaattcac tatgagtcag aatcattaga ctgacttttt   3540

tttttccata gtaatagtat tttgcagagt ctcacagagc tgcagatctt ttgttcatct   3600

tgcagagtta acaagtctga tcctgttagt ccagatttct taaatttggc caagttataa   3660

taggagcagt agcttgagac ccgaagtcag gaaactttga caatggattt ttttttttaa   3720

tccagagact tgtactggaa tttgccttac cctgtcagct catggactta aggtttcatc   3780

ccgctttatg agtgcttctg aatccaagtc attgttacct gaatttgcaa attaagttgt   3840

gatattcgtg actgttaaat tcctgtaatt agattaacct ctttgcttgc ttgtttgttt   3900

tctctcctat tttagcttaa agtatcagtg gttgagaaga gcttttcgga cctgttacta   3960

ccccaagctg tgtaatatac ttgtataaca gaaatacctt ctatacaaac ctttttttct   4020

acttttagat agaaatgtct actttttcag cagttctgtg aattaaagag cagagtgact   4080

gtgggtctgg aatggctggt gtacttggga atgtactatc aggattttac agcaatgctg   4140

ggaaatgaca gggaaaatga caggaatgaa tctcaccaga ttttttatgt actcagcaga   4200

gccttgagtt acggtgttta ttttccaatc aagtgaagat atctcctact tctcctactg   4260

gaacatctca gcttctgcag tgaagaaaaa ttcctgtgat agttcagttc tttagttttt   4320

ctatttgaaa aaaaaaaatc atttaaatga tcctttgttc acggctctcc ttaatgactg   4380

agtgaacagt tcctatctgt atatttgact aaaccttttc ctaagctatc tctcatggtt   4440

cctatgtttt tttatcataa ttaaaagcaa aaccatctgg atcacctaac agtcagaggt   4500

cagtatctca gcgtgtgaat tatagaggaa atacagagag aacctcttcc acttttactt   4560

ttcgtccaaa taaaatgcat ggtgtaccag aagttgaaga tcgggttgag gattggggct   4620

agctcgatga cactaaggcc ccaacatcgc gggacctgct gtggcgcgga ttcttaggaa   4680

cgctgttcta gccggccccc tctccagggg tcgccgtggc cggcattatt tcctagttct   4740

tcttgtaacc ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc taaggatgca   4800

acctctgacg ttctgcgcct tcctaggaga gtcttacatg tgttgagatt tcacaagcaa   4860

tgcgagttgt aaaataccag ctctacaaga agctaggctc tgtgacggca tagttttcag   4920

tagctttatc acaatattca caatggagaa ttatatgaca tggtagcaga aataggccct   4980

tttatgtgtt gcttctattt tacctcaaat tgtagatata gggtaatcaa taaaatccat   5040

ccatgccttt cacacactaa gt                                            5062


<210>  4945
<211>  934
<212>  PRT
<213>  Homo sapiens

<400>  4945

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr 
                245                 250                 255


Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr 
            260                 265                 270


Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn 
        275                 280                 285


Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg 
    290                 295                 300


Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp 
305                 310                 315                 320


Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala 
                325                 330                 335


Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser 
            340                 345                 350


His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe 
        355                 360                 365


Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu 
    370                 375                 380


Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn 
385                 390                 395                 400


Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys 
                405                 410                 415


Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln 
            420                 425                 430


Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys 
        435                 440                 445


Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val 
    450                 455                 460


Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly 
465                 470                 475                 480


Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe 
                485                 490                 495


Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr 
            500                 505                 510


Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala 
        515                 520                 525


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr 
    530                 535                 540


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe 
545                 550                 555                 560


Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys 
                565                 570                 575


Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly 
            580                 585                 590


Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro 
        595                 600                 605


Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val 
    610                 615                 620


Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro 
625                 630                 635                 640


Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu 
                645                 650                 655


Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys 
            660                 665                 670


Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys 
        675                 680                 685


Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp 
    690                 695                 700


Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser 
705                 710                 715                 720


Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys 
                725                 730                 735


Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys 
            740                 745                 750


Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro 
        755                 760                 765


Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln 
    770                 775                 780


Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys 
785                 790                 795                 800


Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe 
                805                 810                 815


Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys 
            820                 825                 830


Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly 
        835                 840                 845


Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg 
    850                 855                 860


Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe 
865                 870                 875                 880


Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu 
                885                 890                 895


Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro 
            900                 905                 910


Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln 
        915                 920                 925


Glu Pro Asp Pro Thr Trp 
    930


<210>  4946
<211>  4168
<212>  DNA
<213>  Homo sapiens

<400>  4946
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1860

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1920

tgaaatttgc ttagatttgt tgacagcggt ttcctggagt gctgtcttga gaacgattct   1980

gaggaggctc agcaagaaag agtgtttcag ttgattgggt gtgtctgtca tggagaagga   2040

actcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac   2100

ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg   2160

tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2220

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2280

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2340

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2400

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2460

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2520

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2580

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2640

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2700

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2760

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2820

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2880

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2940

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   3000

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3060

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca   3120

tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg   3180

atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag   3240

actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc   3300

ctaggagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct cctacttctc   3360

ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta   3420

gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg ctctccttaa   3480

tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa gctatctctc   3540

atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca cctaacagtc   3600

agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc tcttccactt   3660

ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg gttgaggatt   3720

ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg cgcggattct   3780

taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc attatttcct   3840

agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca gggggctaag   3900

gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt gagatttcac   3960

aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg acggcatagt   4020

tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt agcagaaata   4080

ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt aatcaataaa   4140

atccatccat gcctttcaca cactaagt                                      4168


<210>  4947
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  4947

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg 
            420                 425                 430


Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe 
        435                 440                 445


Ala 



<210>  4948
<211>  7125
<212>  DNA
<213>  Homo sapiens

<400>  4948
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggaag ccaccattct tcagagggca atgaaggcac agaaatggaa gtaccagcag   1080

aagattctac tcaacatgtc ccttcagaaa caagtgagga ccctgaagtt gaggtgacta   1140

ttgaagatga tgattattct ccaccgtcta agagaccaaa ggccaatgag ctaccgcagc   1200

caccagtccc ggaacccgcc aatgctggga agcggaaagt gagggagttc aacttcgaga   1260

aatggaatgc tcgcatcact gatctacgta aacaagttga agaattgttt gaaaggaaat   1320

atgctcaagc cataaaagcc aaaggtccgg tgacgatccc gtaccctctt ttccagtctc   1380

atgttgaaga tctttatgta gaaggacttc ctgaaggaat tccttttaga aggccatcta   1440

cttacggaat tcctcgcctg gagaggatat tacttgcaaa ggaaaggatt cgttttgtga   1500

ttaagaaaca tgagcttctg aattcaacac gtgaagattt acagcttgat aagccagctt   1560

caggagtaaa ggaagaatgg tatgccagaa tcactaaatt aagaaagatg gtggatcagc   1620

ttttctgcaa aaaatttgcg gaagccttgg ggagcactga agccaaggct gtaccgtacc   1680

aaaaatttga ggcacacccg aatgatctgt acgtggaagg actgccagaa aacattcctt   1740

tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa aatcattcaa gtgggcaatc   1800

gaattaaatt tgttattaaa agaccagaac ttctgactca cagtaccact gaagttactc   1860

agccaagaac gaatacacca gtcaaagaag attggaatgt cagaattacc aagctacgga   1920

agcaagtgga agagattttt aatttgaaat ttgctcaagc tcttggactc accgaggcag   1980

taaaagtacc atatcctgtg tttgaatcaa acccggagtt cttgtatgtg gaaggcttgc   2040

cagaggggat tcccttccga agccctacct ggtttggaat tccacgactt gaaaggatcg   2100

tccgcgggag taataaaatc aagttcgttg ttaaaaaacc tgaactagtt atttcctact   2160

tgcctcctgg gatggctagt aaaataaaca ctaaagcttt gcagtccccc aaaagaccac   2220

gaagtcctgg gagtaattca aaggttcctg aaattgaggt caccgtggaa ggccctaata   2280

acaacaatcc tcaaacctca gctgttcgaa ccccgaccca gactaacggt tctaacgttc   2340

ccttcaagcc acgagggaga gagttttcct ttgaggcctg gaatgccaaa atcacggacc   2400

taaaacagaa agttgaaaat ctcttcaatg agaaatgtgg ggaagctctt ggccttaaac   2460

aagctgtgaa ggtgccgttc gcgttatttg agtctttccc ggaagacttt tatgtggaag   2520

gcttacctga gggtgtgcca ttccgaagac catcgacttt tggcattccg aggctggaga   2580

agatactcag aaacaaagcc aaaattaagt tcatcattaa aaagcccgaa atgtttgaga   2640

cggcgattaa ggagagcacc tcctctaaga gccctcccag aaaaataaat tcatcaccca   2700

atgttaatac tactgcatca ggtgttgaag accttaacat cattcaggtg acaattccag   2760

atgatgataa tgaaagactc tcgaaagttg aaaaagctag acagctaaga gaacaagtga   2820

atgacctctt tagtcggaaa tttggtgaag ctattggtat gggttttcct gtgaaagttc   2880

cctacaggaa aatcacaatt aaccctggct gtgtggtggt tgatggcatg cccccggggg   2940

tgtccttcaa agcccccagc tacctggaaa tcagctccat gagaaggatc ttagactctg   3000

ccgagtttat caaattcacg gtcattaggt aagtgagagt ttcctgctta gtcacaggag   3060

cgaatctgga gctcatgagg ctgactcttc taaaatgcag ccacaggtag tcatcgaatc   3120

cggcttccta tgctgtgcaa tcaacaaatc aaaataactt gtgtcatcat tagaatgtca   3180

gatgtgcttc tacgaactaa gctgactctt ttaattcttt ggcaaagggt tggcaaacta   3240

ggactgtttg ccaaattcag gctgcctcct atttttagag tcttcctgaa acacagctac   3300

acccgtatta tccatggctg ctttcctgtc acagtgagta agtagctggg actgagaagg   3360

catggcctcc aaagtctaaa atatttactc tctagcactt tgtagaaaaa ccttagctag   3420

gcacagtggc taacgcctgt aatcccagca ttttgggagg ccaaggcagg cagatcacct   3480

gaggtcagga gttccagacc agcctggcca acatggtgaa atcccatctc tacaaaaata   3540

aaacagttag ctgggcatga tggcgggtgc ctgtaatccc agctactcgg gaggctgagg   3600

caggatagtc gcttgaaccc aggaggtgga ggttgcaatg agccaagatc atgccactgc   3660

actccagcct ggacgacaga gtgagactcc atcacaagaa aaaaagaact ttgtcaacct   3720

ctgtcttagg gcgccttgtc acaggcttcg ggtcagacgg attcaacctt gcatcagcca   3780

tttgttagcc aggtcactct gttctttgtc tgtaaatgag attgatcgtt gttcccactg   3840

agagtgtcag ctccttcccg tagagcaggc atgatgattg tactcacctc tgacaccatt   3900

gtgagtgcca cattccttcc cacgtccttg tcactgtaag agatgcccac ctgagcacca   3960

accccaggtt atcttcccct ttgtcttcca gccccccaga aacagctacg actcaaccta   4020

cccaatcatt tcatcatcag attgccactg tctctagttc aggtctcttg ggactggcac   4080

tcagaaatct cataataaat cctcttgagg cttctcatac actcgtcttc ttccaatctt   4140

ctttccctca aaatctcata ttttggttcc acttcaccca ccgtcattct ccatatcact   4200

cccaggagtt aggcaaaaag ccccttccgt tcttccgtat gttaaactta gaatcactct   4260

gttccctgct ctgcgtttct attttttgtt tttcctccat ttactagtag cttaacactt   4320

tctaacagtg ttcttattat tgatacgtat ctatctcttc cataagctta taaggtcacg   4380

gataatactt ctcattgtag tacgtaaatg acgtgggcta gatatgagtt gaataaacag   4440

ttatacctgt aaattcttac agagtgaaaa taaattgtta tactttacaa tttgtttctc   4500

tctttagacc atttccagga cttgtgatta ataaccgtga gtattttgtg aagtgttttg   4560

tttttgtttt ttcctggggt ctgacgtgtg tgcgtgtgag tgtgtataca tgcttaacgt   4620

atatcacgtt acttcaccta tgtcagtaac caggccaaat acttgtttta gccctcagta   4680

aaaacaccag gcacttccta gttgtaaaat tattcaagct tcttaacttc ctatcctcga   4740

tgcacttaat cataaaatgg taataatagc accgattttg ggggagtcgt tccagtagat   4800

ggaaagcatc tggaacaggt gtcagcaagc tcctgccgac gtgtatgcat aaagttttat   4860

tgaaaccacc atcgtgtcca tttgtttatg gcagaactga gagatggcag cagcaagtgt   4920

gtgcctgcaa aacctaaaat atttactaat tggctctgca agaaaagagt ttgcatcccc   4980

ctaacctaga acagtgtcta gcctctagta tgtgtttagc ctacagtatg tgctcagcga   5040

atacaatcta tatttattac tgcttttatg actgttataa ttactgtgct tggatttcgt   5100

tacaaagtaa gtcacaatgt gcctgcttct gttagtattt cagcacagtg cctggcacac   5160

atggggctct caaatattgc tgagcgagtg aacaaatgtc ctttcaattc cttaacgttg   5220

atgtcatttt caatagtatt ttgagccaaa cttaattttg cgagtgtgtt ttgttttctt   5280

aactttatta ttaaaaatgt ataaaagtga ggccaggcgt ggtggctcac gcctgtaatc   5340

ccagcagttt gggaggctga ggcaggcgga tcagttgagg ttgggagttg gagaccagcc   5400

cgtccaacat ggtgaaagcc tgtctctact aaaaatacaa aaatcagctg ggtgtggtgg   5460

cgcgtgcctg taatcccagc tactcaggag gctgaggcag gagagttgct tgaatcctag   5520

aggtggaggt tgcagtgagc tgagatcgtg ccattgcact ccagcctggg caacaagagc   5580

aaaactctgt cccaataaat aaataaataa aatgttctct tttgttcctg ttcttgtgcg   5640

gtagtgtggt atagagtttt atggtaatta ctgtgaatta gtgattctga gggacatatc   5700

agaactctga ggtttgtttc cttctcatct tgagggaaac agcaaatgta tgttaaaatg   5760

cttttccaag ggaacaacac atccttacat tatttaaacc aatctgcttc attttcagag   5820

ctggttgatc agagtgagtc agaaggcccc gtgatacaag aatcagctga accaagccag   5880

ttggaagttc cagccacaga agaaataaaa gagactgatg gaagctctca gatcaagcaa   5940

gaaccagacc ccacgtggta gacctcttcc ctcctaggct taaagtatca gtggttgaga   6000

agagcttttc ggacctgtta ctaccccaag ctgtgtaata tacttgtata acagaaatac   6060

cttctataca aacctttttt tctactttta gatagaaatg tctacttttt cagcagttct   6120

gtgaattaaa gagcagagtg actgtgggtc tggaatggct ggtgtacttg ggaatgtact   6180

atcaggattt tacagcaatg ctgggaaatg acagggaaaa tgacaggaat gaatctcacc   6240

agatttttta tgtactcagc agagccttga gttacggtgt ttattttcca atcaagtgaa   6300

gatatctcct acttctccta ctggaacatc tcagcttctg cagtgaagaa aaattcctgt   6360

gatagttcag ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa tgatcctttg   6420

ttcacggctc tccttaatga ctgagtgaac agttcctatc tgtatatttg actaaacctt   6480

ttcctaagct atctctcatg gttcctatgt ttttttatca taattaaaag caaaaccatc   6540

tggatcacct aacagtcaga ggtcagtatc tcagcgtgtg aattatagag gaaatacaga   6600

gagaacctct tccactttta cttttcgtcc aaataaaatg catggtgtac cagaagttga   6660

agatcgggtt gaggattggg gctagctcga tgacactaag gccccaacat cgcgggacct   6720

gctgtggcgc ggattcttag gaacgctgtt ctagccggcc ccctctccag gggtcgccgt   6780

ggccggcatt atttcctagt tcttcttgta accctgaggt gccagcgcgg ggagtgagga   6840

ggggtcaggg ggctaaggat gcaacctctg acgttctgcg ccttcctagg agagtcttac   6900

atgtgttgag atttcacaag caatgcgagt tgtaaaatac cagctctaca agaagctagg   6960

ctctgtgacg gcatagtttt cagtagcttt atcacaatat tcacaatgga gaattatatg   7020

acatggtagc agaaataggc ccttttatgt gttgcttcta ttttacctca aattgtagat   7080

atagggtaat caataaaatc catccatgcc tttcacacac taagt                   7125


<210>  4949
<211>  876
<212>  PRT
<213>  Homo sapiens

<400>  4949

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val 
    210                 215                 220


Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp 
225                 230                 235                 240


Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
                245                 250                 255


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
            260                 265                 270


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
        275                 280                 285


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
    290                 295                 300


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
305                 310                 315                 320


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
                325                 330                 335


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
            340                 345                 350


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
        355                 360                 365


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
    370                 375                 380


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
385                 390                 395                 400


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
                405                 410                 415


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
            420                 425                 430


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
        435                 440                 445


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
    450                 455                 460


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
465                 470                 475                 480


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
                485                 490                 495


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
            500                 505                 510


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
        515                 520                 525


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu 
    530                 535                 540


Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile 
545                 550                 555                 560


Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val 
                565                 570                 575


Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala 
            580                 585                 590


Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser 
        595                 600                 605


Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly 
    610                 615                 620


Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln 
625                 630                 635                 640


Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser 
                645                 650                 655


Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu 
            660                 665                 670


Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala 
        675                 680                 685


Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr 
    690                 695                 700


Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe 
705                 710                 715                 720


Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys 
                725                 730                 735


Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser 
            740                 745                 750


Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val 
        755                 760                 765


Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr 
    770                 775                 780


Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg 
785                 790                 795                 800


Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu 
                805                 810                 815


Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr 
            820                 825                 830


Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser 
        835                 840                 845


Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu 
    850                 855                 860


Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
865                 870                 875


<210>  4950
<211>  7840
<212>  DNA
<213>  Homo sapiens

<400>  4950
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagctca   1980

agctcttgga ctcaccgagg cagtaaaagt accatatcct gtgtttgaat caaacccgga   2040

gttcttgtat gtggaaggct tgccagaggg gattcccttc cgaagcccta cctggtttgg   2100

aattccacga cttgaaagga tcgtccgcgg gagtaataaa atcaagttcg ttgttaaaaa   2160

acctgaacta gttatttcct acttgcctcc tgggatggct agtaaaataa acactaaagc   2220

tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat tcaaaggttc ctgaaattga   2280

ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc tcagctgttc gaaccccgac   2340

ccagactaac ggttctaacg ttcccttcaa gccacgaggg agagagtttt cctttgaggc   2400

ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa aatctcttca atgagaaatg   2460

tggggaagct cttggcctta aacaagctgt gaaggtgccg ttcgcgttat ttgagtcttt   2520

cccggaagac ttttatgtgg aaggcttacc tgagggtgtg ccattccgaa gaccatcgac   2580

ttttggcatt ccgaggctgg agaagatact cagaaacaaa gccaaaatta agttcatcat   2640

taaaaagccc gaaatgtttg agacggcgat taaggagagc acctcctcta agagccctcc   2700

cagaaaaata aattcatcac ccaatgttaa tactactgca tcaggtgttg aagaccttaa   2760

catcattcag gtgacaattc cagatgatga taatgaaaga ctctcgaaag ttgaaaaagc   2820

tagacagcta agagaacaag tgaatgacct ctttagtcgg aaatttggtg aagctattgg   2880

tatgggtttt cctgtgaaag ttccctacag gaaaatcaca attaaccctg gctgtgtggt   2940

ggttgatggc atgcccccgg gggtgtcctt caaagccccc agctacctgg aaatcagctc   3000

catgagaagg atcttagact ctgccgagtt tatcaaattc acggtcatta ggtaagtgag   3060

agtttcctgc ttagtcacag gagcgaatct ggagctcatg aggctgactc ttctaaaatg   3120

cagccacagg tagtcatcga atccggcttc ctatgctgtg caatcaacaa atcaaaataa   3180

cttgtgtcat cattagaatg tcagatgtgc ttctacgaac taagctgact cttttaattc   3240

tttggcaaag ggttggcaaa ctaggactgt ttgccaaatt caggctgcct cctattttta   3300

gagtcttcct gaaacacagc tacacccgta ttatccatgg ctgctttcct gtcacagtga   3360

gtaagtagct gggactgaga aggcatggcc tccaaagtct aaaatattta ctctctagca   3420

ctttgtagaa aaaccttagc taggcacagt ggctaacgcc tgtaatccca gcattttggg   3480

aggccaaggc aggcagatca cctgaggtca ggagttccag accagcctgg ccaacatggt   3540

gaaatcccat ctctacaaaa ataaaacagt tagctgggca tgatggcggg tgcctgtaat   3600

cccagctact cgggaggctg aggcaggata gtcgcttgaa cccaggaggt ggaggttgca   3660

atgagccaag atcatgccac tgcactccag cctggacgac agagtgagac tccatcacaa   3720

gaaaaaaaga actttgtcaa cctctgtctt agggcgcctt gtcacaggct tcgggtcaga   3780

cggattcaac cttgcatcag ccatttgtta gccaggtcac tctgttcttt gtctgtaaat   3840

gagattgatc gttgttccca ctgagagtgt cagctccttc ccgtagagca ggcatgatga   3900

ttgtactcac ctctgacacc attgtgagtg ccacattcct tcccacgtcc ttgtcactgt   3960

aagagatgcc cacctgagca ccaaccccag gttatcttcc cctttgtctt ccagcccccc   4020

agaaacagct acgactcaac ctacccaatc atttcatcat cagattgcca ctgtctctag   4080

ttcaggtctc ttgggactgg cactcagaaa tctcataata aatcctcttg aggcttctca   4140

tacactcgtc ttcttccaat cttctttccc tcaaaatctc atattttggt tccacttcac   4200

ccaccgtcat tctccatatc actcccagga gttaggcaaa aagccccttc cgttcttccg   4260

tatgttaaac ttagaatcac tctgttccct gctctgcgtt tctatttttt gtttttcctc   4320

catttactag tagcttaaca ctttctaaca gtgttcttat tattgatacg tatctatctc   4380

ttccataagc ttataaggtc acggataata cttctcattg tagtacgtaa atgacgtggg   4440

ctagatatga gttgaataaa cagttatacc tgtaaattct tacagagtga aaataaattg   4500

ttatacttta caatttgttt ctctctttag accatttcca ggacttgtga ttaataaccg   4560

tgagtatttt gtgaagtgtt ttgtttttgt tttttcctgg ggtctgacgt gtgtgcgtgt   4620

gagtgtgtat acatgcttaa cgtatatcac gttacttcac ctatgtcagt aaccaggcca   4680

aatacttgtt ttagccctca gtaaaaacac caggcacttc ctagttgtaa aattattcaa   4740

gcttcttaac ttcctatcct cgatgcactt aatcataaaa tggtaataat agcaccgatt   4800

ttgggggagt cgttccagta gatggaaagc atctggaaca ggtgtcagca agctcctgcc   4860

gacgtgtatg cataaagttt tattgaaacc accatcgtgt ccatttgttt atggcagaac   4920

tgagagatgg cagcagcaag tgtgtgcctg caaaacctaa aatatttact aattggctct   4980

gcaagaaaag agtttgcatc cccctaacct agaacagtgt ctagcctcta gtatgtgttt   5040

agcctacagt atgtgctcag cgaatacaat ctatatttat tactgctttt atgactgtta   5100

taattactgt gcttggattt cgttacaaag taagtcacaa tgtgcctgct tctgttagta   5160

tttcagcaca gtgcctggca cacatggggc tctcaaatat tgctgagcga gtgaacaaat   5220

gtcctttcaa ttccttaacg ttgatgtcat tttcaatagt attttgagcc aaacttaatt   5280

ttgcgagtgt gttttgtttt cttaacttta ttattaaaaa tgtataaaag tgaggccagg   5340

cgtggtggct cacgcctgta atcccagcag tttgggaggc tgaggcaggc ggatcagttg   5400

aggttgggag ttggagacca gcccgtccaa catggtgaaa gcctgtctct actaaaaata   5460

caaaaatcag ctgggtgtgg tggcgcgtgc ctgtaatccc agctactcag gaggctgagg   5520

caggagagtt gcttgaatcc tagaggtgga ggttgcagtg agctgagatc gtgccattgc   5580

actccagcct gggcaacaag agcaaaactc tgtcccaata aataaataaa taaaatgttc   5640

tcttttgttc ctgttcttgt gcggtagtgt ggtatagagt tttatggtaa ttactgtgaa   5700

ttagtgattc tgagggacat atcagaactc tgaggtttgt ttccttctca tcttgaggga   5760

aacagcaaat gtatgttaaa atgcttttcc aagggaacaa cacatcctta cattatttaa   5820

accaatctgc ttcattttca gagctggttg atcagagtga gtcagaaggc cccgtgatac   5880

aagaatcagc tgaaccaagc cagttggaag ttccagccac agaagaaata aaagagactg   5940

atggaagctc tcagatcaag caagaaccag accccacgtg gtagacctct tccctcctag   6000

ggtaaatcag cttctgtgtc agggatgctg tgtggtgtcc atctgaaccc cctgcatacg   6060

cgtagctaat gtgatctccc cactttcaca taagatggtg gccctgcctt cagggaatgt   6120

gggagccagg tgggagcctt cccggatatt taagctagaa gattctacag ggagattctc   6180

cttggatcaa tatatgtctc tcagtcaaag atgtaaaagc acttttgcct taaaaagaat   6240

gttctgtttc taaatagagt caacgttgtc ctcctcattg gaattcacta tgagtcagaa   6300

tcattagact gacttttttt tttccatagt aatagtattt tgcagagtct cacagagctg   6360

cagatctttt gttcatcttg cagagttaac aagtctgatc ctgttagtcc agatttctta   6420

aatttggcca agttataata ggagcagtag cttgagaccc gaagtcagga aactttgaca   6480

atggattttt ttttttaatc cagagacttg tactggaatt tgccttaccc tgtcagctca   6540

tggacttaag gtttcatccc gctttatgag tgcttctgaa tccaagtcat tgttacctga   6600

atttgcaaat taagttgtga tattcgtgac tgttaaattc ctgtaattag attaacctct   6660

ttgcttgctt gtttgttttc tctcctattt tagcttaaag tatcagtggt tgagaagagc   6720

ttttcggacc tgttactacc ccaagctgtg taatatactt gtataacaga aataccttct   6780

atacaaacct ttttttctac ttttagatag aaatgtctac tttttcagca gttctgtgaa   6840

ttaaagagca gagtgactgt gggtctggaa tggctggtgt acttgggaat gtactatcag   6900

gattttacag caatgctggg aaatgacagg gaaaatgaca ggaatgaatc tcaccagatt   6960

ttttatgtac tcagcagagc cttgagttac ggtgtttatt ttccaatcaa gtgaagatat   7020

ctcctacttc tcctactgga acatctcagc ttctgcagtg aagaaaaatt cctgtgatag   7080

ttcagttctt tagtttttct atttgaaaaa aaaaaatcat ttaaatgatc ctttgttcac   7140

ggctctcctt aatgactgag tgaacagttc ctatctgtat atttgactaa accttttcct   7200

aagctatctc tcatggttcc tatgtttttt tatcataatt aaaagcaaaa ccatctggat   7260

cacctaacag tcagaggtca gtatctcagc gtgtgaatta tagaggaaat acagagagaa   7320

cctcttccac ttttactttt cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc   7380

gggttgagga ttggggctag ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt   7440

ggcgcggatt cttaggaacg ctgttctagc cggccccctc tccaggggtc gccgtggccg   7500

gcattatttc ctagttcttc ttgtaaccct gaggtgccag cgcggggagt gaggaggggt   7560

cagggggcta aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg   7620

ttgagatttc acaagcaatg cgagttgtaa aataccagct ctacaagaag ctaggctctg   7680

tgacggcata gttttcagta gctttatcac aatattcaca atggagaatt atatgacatg   7740

gtagcagaaa taggcccttt tatgtgttgc ttctatttta cctcaaattg tagatatagg   7800

gtaatcaata aaatccatcc atgcctttca cacactaagt                         7840


<210>  4951
<211>  877
<212>  PRT
<213>  Homo sapiens

<400>  4951

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
        515                 520                 525


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
    530                 535                 540


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
545                 550                 555                 560


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
                565                 570                 575


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
            580                 585                 590


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
        595                 600                 605


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
    610                 615                 620


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
625                 630                 635                 640


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
                645                 650                 655


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
            660                 665                 670


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
        675                 680                 685


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
    690                 695                 700


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
705                 710                 715                 720


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
                725                 730                 735


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
            740                 745                 750


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
        755                 760                 765


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
    770                 775                 780


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
785                 790                 795                 800


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
                805                 810                 815


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
            820                 825                 830


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
        835                 840                 845


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
    850                 855                 860


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
865                 870                 875


<210>  4952
<211>  4028
<212>  DNA
<213>  Homo sapiens

<400>  4952
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caaggaagcc accattcttc agagggcaat gaaggcacag   1140

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1200

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1260

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1320

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1380

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1440

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1500

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1560

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1620

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1680

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1740

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1800

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1860

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1920

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   1980

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttga   2040

aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg aactagttat   2100

ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc agtcccccaa   2160

aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg   2220

ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga ctaacggttc   2280

taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga atgccaaaat   2340

cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg   2400

ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg aagactttta   2460

tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg gcattccgag   2520

gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa agcccgaaat   2580

gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa aaataaattc   2640

atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca ttcaggtgac   2700

aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac agctaagaga   2760

acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg gttttcctgt   2820

gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg atggcatgcc   2880

cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga gaaggatctt   2940

agactctgcc gagtttatca aattcacggt cattagacca tttccaggac ttgtgattaa   3000

taaccagctg gttgatcaga gtgagtcaga aggccccgtg atacaagaat cagctgaacc   3060

aagccagttg gaagttccag ccacagaaga aataaaagag actgatggaa gctctcagat   3120

caagcaagaa ccagacccca cgtggtagac ctcttccctc ctaggagcct tgagttacgg   3180

tgtttatttt ccaatcaagt gaagatatct cctacttctc ctactggaac atctcagctt   3240

ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa   3300

aaaatcattt aaatgatcct ttgttcacgg ctctccttaa tgactgagtg aacagttcct   3360

atctgtatat ttgactaaac cttttcctaa gctatctctc atggttccta tgttttttta   3420

tcataattaa aagcaaaacc atctggatca cctaacagtc agaggtcagt atctcagcgt   3480

gtgaattata gaggaaatac agagagaacc tcttccactt ttacttttcg tccaaataaa   3540

atgcatggtg taccagaagt tgaagatcgg gttgaggatt ggggctagct cgatgacact   3600

aaggccccaa catcgcggga cctgctgtgg cgcggattct taggaacgct gttctagccg   3660

gccccctctc caggggtcgc cgtggccggc attatttcct agttcttctt gtaaccctga   3720

ggtgccagcg cggggagtga ggaggggtca gggggctaag gatgcaacct ctgacgttct   3780

gcgccttcct aggagagtct tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa   3840

taccagctct acaagaagct aggctctgtg acggcatagt tttcagtagc tttatcacaa   3900

tattcacaat ggagaattat atgacatggt agcagaaata ggccctttta tgtgttgctt   3960

ctattttacc tcaaattgta gatatagggt aatcaataaa atccatccat gcctttcaca   4020

cactaagt                                                            4028


<210>  4953
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  4953

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser 
225                 230                 235                 240


Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp 
                245                 250                 255


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
            260                 265                 270


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
        275                 280                 285


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
    290                 295                 300


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
305                 310                 315                 320


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
                325                 330                 335


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
            340                 345                 350


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
        355                 360                 365


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
    370                 375                 380


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
385                 390                 395                 400


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
                405                 410                 415


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
            420                 425                 430


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
        435                 440                 445


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
    450                 455                 460


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
465                 470                 475                 480


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
                485                 490                 495


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
            500                 505                 510


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
        515                 520                 525


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
    530                 535                 540


Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu 
545                 550                 555                 560


Lys Asn Leu Asn 



<210>  4954
<211>  7133
<212>  DNA
<213>  Homo sapiens

<400>  4954
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc cgttgaagat gaggagtcct cggagagcag gatggtggtg acattcctca    420

tgtcagctct cgagtccatg tgtaaagaac tggccaagtc caaagccgaa gtggcctgca    480

ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga aagaggacgt gcttttgtca    540

ataccagaaa ggattttcaa aaagattttg taaaatattg tgttgaagaa gaagaaaaag    600

ctgcagagat gcataaaatg aaatctacaa cccaggcaaa tcggatgagt gtagatgctg    660

tagaaattga aacactcaga aaaacagttg aggactattt ctgcttttgc tatgggaaag    720

ctttaggcaa atccacagtg gtacctgtac catatgagaa gatgctgcga gaccagtcgg    780

ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa acaccccgag aactatgatc    840

ttgcaaccct gaaatggatt ttggagaaca aagcagggat ttcattcatc attaagagac    900

cttttttaga gccaaagaag catgtaggtg gtcgtgtgat ggtaacagat gctgacaggt    960

caatactatc tccaggtgga agttgtggcc ccatcaaagt gaaaactgaa cccacagaag   1020

attctggcat ttccctggaa atggcagctg tgacagtaaa ggaagaatca gaagatcctg   1080

attattatca atataacatt caagcaggcc cttctgaaac tgatgatgtt gatgaaaaac   1140

agcccctatc gaagcctttg caaggaagcc accattcttc agagggcaat gaaggcacag   1200

aaatggaagt accagcagaa gatgatgatt attctccacc gtctaagaga ccaaaggcca   1260

atgagctacc gcagccacca gtcccggaac ccgccaatgc tgggaagcgg aaagtgaggg   1320

agttcaactt cgagaaatgg aatgctcgca tcactgatct acgtaaacaa gttgaagaat   1380

tgtttgaaag gaaatatgct caagccataa aagccaaagg tccggtgacg atcccgtacc   1440

ctcttttcca gtctcatgtt gaagatcttt atgtagaagg acttcctgaa ggaattcctt   1500

ttagaaggcc atctacttac ggaattcctc gcctggagag gatattactt gcaaaggaaa   1560

ggattcgttt tgtgattaag aaacatgagc ttctgaattc aacacgtgaa gatttacagc   1620

ttgataagcc agcttcagga gtaaaggaag aatggtatgc cagaatcact aaattaagaa   1680

agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc cttggggagc actgaagcca   1740

aggctgtacc gtaccaaaaa tttgaggcac acccgaatga tctgtacgtg gaaggactgc   1800

cagaaaacat tcctttccga agtccctcat ggtatggaat cccaaggctg gaaaaaatca   1860

ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc agaacttctg actcacagta   1920

ccactgaagt tactcagcca agaacgaata caccagtcaa agaagattgg aatgtcagaa   1980

ttaccaagct acggaagcaa gtggaagaga tttttaattt gaaatttgct caagctcttg   2040

gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga atcaaacccg gagttcttga   2100

aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt aaaaaacctg aactagttat   2160

ttcctacttg cctcctggga tggctagtaa aataaacact aaagctttgc agtcccccaa   2220

aagaccacga agtcctggga gtaattcaaa ggttcctgaa attgaggtca ccgtggaagg   2280

ccctaataac aacaatcctc aaacctcagc tgttcgaacc ccgacccaga ctaacggttc   2340

taacgttccc ttcaagccac gagggagaga gttttccttt gaggcctgga atgccaaaat   2400

cacggaccta aaacagaaag ttgaaaatct cttcaatgag aaatgtgggg aagctcttgg   2460

ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag tctttcccgg aagactttta   2520

tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca tcgacttttg gcattccgag   2580

gctggagaag atactcagaa acaaagccaa aattaagttc atcattaaaa agcccgaaat   2640

gtttgagacg gcgattaagg agagcacctc ctctaagagc cctcccagaa aaataaattc   2700

atcacccaat gttaatacta ctgcatcagg tgttgaagac cttaacatca ttcaggtgac   2760

aattccagat gatgataatg aaagactctc gaaagttgaa aaagctagac agctaagaga   2820

acaagtgaat gacctcttta gtcggaaatt tggtgaagct attggtatgg gttttcctgt   2880

gaaagttccc tacaggaaaa tcacaattaa ccctggctgt gtggtggttg atggcatgcc   2940

cccgggggtg tccttcaaag cccccagcta cctggaaatc agctccatga gaaggatctt   3000

agactctgcc gagtttatca aattcacggt cattaggtaa gtgagagttt cctgcttagt   3060

cacaggagcg aatctggagc tcatgaggct gactcttcta aaatgcagcc acaggtagtc   3120

atcgaatccg gcttcctatg ctgtgcaatc aacaaatcaa aataacttgt gtcatcatta   3180

gaatgtcaga tgtgcttcta cgaactaagc tgactctttt aattctttgg caaagggttg   3240

gcaaactagg actgtttgcc aaattcaggc tgcctcctat ttttagagtc ttcctgaaac   3300

acagctacac ccgtattatc catggctgct ttcctgtcac agtgagtaag tagctgggac   3360

tgagaaggca tggcctccaa agtctaaaat atttactctc tagcactttg tagaaaaacc   3420

ttagctaggc acagtggcta acgcctgtaa tcccagcatt ttgggaggcc aaggcaggca   3480

gatcacctga ggtcaggagt tccagaccag cctggccaac atggtgaaat cccatctcta   3540

caaaaataaa acagttagct gggcatgatg gcgggtgcct gtaatcccag ctactcggga   3600

ggctgaggca ggatagtcgc ttgaacccag gaggtggagg ttgcaatgag ccaagatcat   3660

gccactgcac tccagcctgg acgacagagt gagactccat cacaagaaaa aaagaacttt   3720

gtcaacctct gtcttagggc gccttgtcac aggcttcggg tcagacggat tcaaccttgc   3780

atcagccatt tgttagccag gtcactctgt tctttgtctg taaatgagat tgatcgttgt   3840

tcccactgag agtgtcagct ccttcccgta gagcaggcat gatgattgta ctcacctctg   3900

acaccattgt gagtgccaca ttccttccca cgtccttgtc actgtaagag atgcccacct   3960

gagcaccaac cccaggttat cttccccttt gtcttccagc cccccagaaa cagctacgac   4020

tcaacctacc caatcatttc atcatcagat tgccactgtc tctagttcag gtctcttggg   4080

actggcactc agaaatctca taataaatcc tcttgaggct tctcatacac tcgtcttctt   4140

ccaatcttct ttccctcaaa atctcatatt ttggttccac ttcacccacc gtcattctcc   4200

atatcactcc caggagttag gcaaaaagcc ccttccgttc ttccgtatgt taaacttaga   4260

atcactctgt tccctgctct gcgtttctat tttttgtttt tcctccattt actagtagct   4320

taacactttc taacagtgtt cttattattg atacgtatct atctcttcca taagcttata   4380

aggtcacgga taatacttct cattgtagta cgtaaatgac gtgggctaga tatgagttga   4440

ataaacagtt atacctgtaa attcttacag agtgaaaata aattgttata ctttacaatt   4500

tgtttctctc tttagaccat ttccaggact tgtgattaat aaccgtgagt attttgtgaa   4560

gtgttttgtt tttgtttttt cctggggtct gacgtgtgtg cgtgtgagtg tgtatacatg   4620

cttaacgtat atcacgttac ttcacctatg tcagtaacca ggccaaatac ttgttttagc   4680

cctcagtaaa aacaccaggc acttcctagt tgtaaaatta ttcaagcttc ttaacttcct   4740

atcctcgatg cacttaatca taaaatggta ataatagcac cgattttggg ggagtcgttc   4800

cagtagatgg aaagcatctg gaacaggtgt cagcaagctc ctgccgacgt gtatgcataa   4860

agttttattg aaaccaccat cgtgtccatt tgtttatggc agaactgaga gatggcagca   4920

gcaagtgtgt gcctgcaaaa cctaaaatat ttactaattg gctctgcaag aaaagagttt   4980

gcatccccct aacctagaac agtgtctagc ctctagtatg tgtttagcct acagtatgtg   5040

ctcagcgaat acaatctata tttattactg cttttatgac tgttataatt actgtgcttg   5100

gatttcgtta caaagtaagt cacaatgtgc ctgcttctgt tagtatttca gcacagtgcc   5160

tggcacacat ggggctctca aatattgctg agcgagtgaa caaatgtcct ttcaattcct   5220

taacgttgat gtcattttca atagtatttt gagccaaact taattttgcg agtgtgtttt   5280

gttttcttaa ctttattatt aaaaatgtat aaaagtgagg ccaggcgtgg tggctcacgc   5340

ctgtaatccc agcagtttgg gaggctgagg caggcggatc agttgaggtt gggagttgga   5400

gaccagcccg tccaacatgg tgaaagcctg tctctactaa aaatacaaaa atcagctggg   5460

tgtggtggcg cgtgcctgta atcccagcta ctcaggaggc tgaggcagga gagttgcttg   5520

aatcctagag gtggaggttg cagtgagctg agatcgtgcc attgcactcc agcctgggca   5580

acaagagcaa aactctgtcc caataaataa ataaataaaa tgttctcttt tgttcctgtt   5640

cttgtgcggt agtgtggtat agagttttat ggtaattact gtgaattagt gattctgagg   5700

gacatatcag aactctgagg tttgtttcct tctcatcttg agggaaacag caaatgtatg   5760

ttaaaatgct tttccaaggg aacaacacat ccttacatta tttaaaccaa tctgcttcat   5820

tttcagagct ggttgatcag agtgagtcag aaggccccgt gatacaagaa tcagctgaac   5880

caagccagtt ggaagttcca gccacagaag aaataaaaga gactgatgga agctctcaga   5940

tcaagcaaga accagacccc acgtggtaga cctcttccct cctaggctta aagtatcagt   6000

ggttgagaag agcttttcgg acctgttact accccaagct gtgtaatata cttgtataac   6060

agaaatacct tctatacaaa cctttttttc tacttttaga tagaaatgtc tactttttca   6120

gcagttctgt gaattaaaga gcagagtgac tgtgggtctg gaatggctgg tgtacttggg   6180

aatgtactat caggatttta cagcaatgct gggaaatgac agggaaaatg acaggaatga   6240

atctcaccag attttttatg tactcagcag agccttgagt tacggtgttt attttccaat   6300

caagtgaaga tatctcctac ttctcctact ggaacatctc agcttctgca gtgaagaaaa   6360

attcctgtga tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat catttaaatg   6420

atcctttgtt cacggctctc cttaatgact gagtgaacag ttcctatctg tatatttgac   6480

taaacctttt cctaagctat ctctcatggt tcctatgttt ttttatcata attaaaagca   6540

aaaccatctg gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa ttatagagga   6600

aatacagaga gaacctcttc cacttttact tttcgtccaa ataaaatgca tggtgtacca   6660

gaagttgaag atcgggttga ggattggggc tagctcgatg acactaaggc cccaacatcg   6720

cgggacctgc tgtggcgcgg attcttagga acgctgttct agccggcccc ctctccaggg   6780

gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg   6840

agtgaggagg ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc ttcctaggag   6900

agtcttacat gtgttgagat ttcacaagca atgcgagttg taaaatacca gctctacaag   6960

aagctaggct ctgtgacggc atagttttca gtagctttat cacaatattc acaatggaga   7020

attatatgac atggtagcag aaataggccc ttttatgtgt tgcttctatt ttacctcaaa   7080

ttgtagatat agggtaatca ataaaatcca tccatgcctt tcacacacta agt          7133


<210>  4955
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  4955

Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser Met Cys Lys Glu 
1               5                   10                  15


Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala Val Tyr Glu Thr 
            20                  25                  30


Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala Phe Val Asn Thr 
        35                  40                  45


Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys Val Glu Glu Glu 
    50                  55                  60


Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr Thr Gln Ala Asn 
65                  70                  75                  80


Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val 
                85                  90                  95


Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr 
            100                 105                 110


Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val 
        115                 120                 125


Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn 
    130                 135                 140


Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile 
145                 150                 155                 160


Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly 
                165                 170                 175


Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly 
            180                 185                 190


Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser 
        195                 200                 205


Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu 
    210                 215                 220


Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly Pro Ser Glu Thr 
225                 230                 235                 240


Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro Leu Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
                565                 570                 575


Ser Ser Leu Leu Lys Asn Leu Asn 
            580


<210>  4956
<211>  4071
<212>  DNA
<213>  Homo sapiens

<400>  4956
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1980

catatcctgt gtttgaatca aacccggagt tcttgtatgt ggaaggcttg ccagagggga   2040

ttcccttccg aagccctacc tggtttggaa ttccacgact tgaaaggatc gtccgcggga   2100

gtaataaaat caagttcgtt gttaaaaaac ctgaactagt tatttcctac ttgcctcctg   2160

ggatggctag taaaataaac actaaagctt tgcagtcccc caaaagacca cgaagtcctg   2220

ggagtaattc aaaggttcct gaaattgagg tcaccgtgga aggccctaat aacaacaatc   2280

ctcaaacctc agctgttcga accccgaccc agactaacgg ttctaacgtt cccttcaagc   2340

cacgagggag agagttttcc tttgaggcct ggaatgccaa aatcacggac ctaaaacaga   2400

aagttgaaaa tctcttcaat gagaaatgtg gggaagctct tggccttaaa caagctgtga   2460

aggtgccgtt cgcgttattt gagtctttcc cggaagactt ttatgtggaa ggcttacctg   2520

agggtgtgcc attccgaaga ccatcgactt ttggcattcc gaggctggag aagatactca   2580

gaaacaaagc caaaattaag ttcatcatta aaaagcccga aatgtttgag acggcgatta   2640

aggagagcac ctcctctaag agccctccca gaaaaataaa ttcatcaccc aatgttaata   2700

ctactgcatc aggtgttgaa gaccttaaca tcattcaggt gacaattcca gatgatgata   2760

atgaaagact ctcgaaagtt gaaaaagcta gacagctaag agaacaagtg aatgacctct   2820

ttagtcggaa atttggtgaa gctattggta tgggttttcc tgtgaaagtt ccctacagga   2880

aaatcacaat taaccctggc tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca   2940

aagcccccag ctacctggaa atcagctcca tgagaaggat cttagactct gccgagttta   3000

tcaaattcac ggtcattaga ccatttccag gacttgtgat taataaccag ctggttgatc   3060

agagtgagtc agaaggcccc gtgatacaag aatcagctga accaagccag ttggaagttc   3120

cagccacaga agaaataaaa gagactgatg gaagctctca gatcaagcaa gaaccagacc   3180

ccacgtggta gacctcttcc ctcctaggag ccttgagtta cggtgtttat tttccaatca   3240

agtgaagata tctcctactt ctcctactgg aacatctcag cttctgcagt gaagaaaaat   3300

tcctgtgata gttcagttct ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat   3360

cctttgttca cggctctcct taatgactga gtgaacagtt cctatctgta tatttgacta   3420

aaccttttcc taagctatct ctcatggttc ctatgttttt ttatcataat taaaagcaaa   3480

accatctgga tcacctaaca gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa   3540

tacagagaga acctcttcca cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga   3600

agttgaagat cgggttgagg attggggcta gctcgatgac actaaggccc caacatcgcg   3660

ggacctgctg tggcgcggat tcttaggaac gctgttctag ccggccccct ctccaggggt   3720

cgccgtggcc ggcattattt cctagttctt cttgtaaccc tgaggtgcca gcgcggggag   3780

tgaggagggg tcagggggct aaggatgcaa cctctgacgt tctgcgcctt cctaggagag   3840

tcttacatgt gttgagattt cacaagcaat gcgagttgta aaataccagc tctacaagaa   3900

gctaggctct gtgacggcat agttttcagt agctttatca caatattcac aatggagaat   3960

tatatgacat ggtagcagaa ataggccctt ttatgtgttg cttctatttt acctcaaatt   4020

gtagatatag ggtaatcaat aaaatccatc catgcctttc acacactaag t            4071


<210>  4957
<211>  868
<212>  PRT
<213>  Homo sapiens

<400>  4957

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser 
            180                 185                 190


Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro 
        195                 200                 205


Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp 
    210                 215                 220


Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu 
225                 230                 235                 240


Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro 
                245                 250                 255


Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu 
            260                 265                 270


Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg 
        275                 280                 285


Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys 
    290                 295                 300


Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys 
305                 310                 315                 320


Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu 
                325                 330                 335


Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu 
            340                 345                 350


Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His 
        355                 360                 365


Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg 
    370                 375                 380


Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val 
385                 390                 395                 400


Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His 
                405                 410                 415


Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu 
            420                 425                 430


Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile 
        435                 440                 445


Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys 
    450                 455                 460


Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu 
465                 470                 475                 480


Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile 
                485                 490                 495


Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val 
            500                 505                 510


Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala 
        515                 520                 525


Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser 
    530                 535                 540


Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly 
545                 550                 555                 560


Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln 
                565                 570                 575


Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser 
            580                 585                 590


Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu 
        595                 600                 605


Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala 
    610                 615                 620


Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr 
625                 630                 635                 640


Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe 
                645                 650                 655


Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys 
            660                 665                 670


Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser 
        675                 680                 685


Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val 
    690                 695                 700


Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr 
705                 710                 715                 720


Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg 
                725                 730                 735


Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu 
            740                 745                 750


Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr 
        755                 760                 765


Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser 
    770                 775                 780


Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu 
785                 790                 795                 800


Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly 
                805                 810                 815


Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro 
            820                 825                 830


Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr 
        835                 840                 845


Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro 
    850                 855                 860


Asp Pro Thr Trp 
865


<210>  4958
<211>  7455
<212>  DNA
<213>  Homo sapiens

<400>  4958
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2100

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2160

tttgaaattt gcttagattt gttgacagcg gtttcctgga gtgctgtctt gagaacgatt   2220

ctgaggaggc tcagcaagaa agagtgtttc agttgattgg gtgtgtctgt catggagaag   2280

gaactcaagc tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa   2340

acccggagtt cttgtatgtg gaaggcttgc cagaggggat tcccttccga agccctacct   2400

ggtttggaat tccacgactt gaaaggatcg tccgcgggag taataaaatc aagttcgttg   2460

ttaaaaaacc tgaactagtt atttcctact tgcctcctgg gatggctagt aaaataaaca   2520

ctaaagcttt gcagtccccc aaaagaccac gaagtcctgg gagtaattca aaggttcctg   2580

aaattgaggt caccgtggaa ggccctaata acaacaatcc tcaaacctca gctgttcgaa   2640

ccccgaccca gactaacggt tctaacgttc ccttcaagcc acgagggaga gagttttcct   2700

ttgaggcctg gaatgccaaa atcacggacc taaaacagaa agttgaaaat ctcttcaatg   2760

agaaatgtgg ggaagctctt ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg   2820

agtctttccc ggaagacttt tatgtggaag gcttacctga gggtgtgcca ttccgaagac   2880

catcgacttt tggcattccg aggctggaga agatactcag aaacaaagcc aaaattaagt   2940

tcatcattaa aaagcccgaa atgtttgaga cggcgattaa ggagagcacc tcctctaaga   3000

gccctcccag aaaaataaat tcatcaccca atgttaatac tactgcatca ggtgttgaag   3060

accttaacat cattcaggtg acaattccag atgatgataa tgaaagactc tcgaaagttg   3120

aaaaagctag acagctaaga gaacaagtga atgacctctt tagtcggaaa tttggtgaag   3180

ctattggtat gggttttcct gtgaaagttc cctacaggaa aatcacaatt aaccctggct   3240

gtgtggtggt tgatggcatg cccccggggg tgtccttcaa agcccccagc tacctggaaa   3300

tcagctccat gagaaggatc ttagactctg ccgagtttat caaattcacg gtcattaggt   3360

aagtgagagt ttcctgctta gtcacaggag cgaatctgga gctcatgagg ctgactcttc   3420

taaaatgcag ccacaggtag tcatcgaatc cggcttccta tgctgtgcaa tcaacaaatc   3480

aaaataactt gtgtcatcat tagaatgtca gatgtgcttc tacgaactaa gctgactctt   3540

ttaattcttt ggcaaagggt tggcaaacta ggactgtttg ccaaattcag gctgcctcct   3600

atttttagag tcttcctgaa acacagctac acccgtatta tccatggctg ctttcctgtc   3660

acagtgagta agtagctggg actgagaagg catggcctcc aaagtctaaa atatttactc   3720

tctagcactt tgtagaaaaa ccttagctag gcacagtggc taacgcctgt aatcccagca   3780

ttttgggagg ccaaggcagg cagatcacct gaggtcagga gttccagacc agcctggcca   3840

acatggtgaa atcccatctc tacaaaaata aaacagttag ctgggcatga tggcgggtgc   3900

ctgtaatccc agctactcgg gaggctgagg caggatagtc gcttgaaccc aggaggtgga   3960

ggttgcaatg agccaagatc atgccactgc actccagcct ggacgacaga gtgagactcc   4020

atcacaagaa aaaaagaact ttgtcaacct ctgtcttagg gcgccttgtc acaggcttcg   4080

ggtcagacgg attcaacctt gcatcagcca tttgttagcc aggtcactct gttctttgtc   4140

tgtaaatgag attgatcgtt gttcccactg agagtgtcag ctccttcccg tagagcaggc   4200

atgatgattg tactcacctc tgacaccatt gtgagtgcca cattccttcc cacgtccttg   4260

tcactgtaag agatgcccac ctgagcacca accccaggtt atcttcccct ttgtcttcca   4320

gccccccaga aacagctacg actcaaccta cccaatcatt tcatcatcag attgccactg   4380

tctctagttc aggtctcttg ggactggcac tcagaaatct cataataaat cctcttgagg   4440

cttctcatac actcgtcttc ttccaatctt ctttccctca aaatctcata ttttggttcc   4500

acttcaccca ccgtcattct ccatatcact cccaggagtt aggcaaaaag ccccttccgt   4560

tcttccgtat gttaaactta gaatcactct gttccctgct ctgcgtttct attttttgtt   4620

tttcctccat ttactagtag cttaacactt tctaacagtg ttcttattat tgatacgtat   4680

ctatctcttc cataagctta taaggtcacg gataatactt ctcattgtag tacgtaaatg   4740

acgtgggcta gatatgagtt gaataaacag ttatacctgt aaattcttac agagtgaaaa   4800

taaattgtta tactttacaa tttgtttctc tctttagacc atttccagga cttgtgatta   4860

ataaccgtga gtattttgtg aagtgttttg tttttgtttt ttcctggggt ctgacgtgtg   4920

tgcgtgtgag tgtgtataca tgcttaacgt atatcacgtt acttcaccta tgtcagtaac   4980

caggccaaat acttgtttta gccctcagta aaaacaccag gcacttccta gttgtaaaat   5040

tattcaagct tcttaacttc ctatcctcga tgcacttaat cataaaatgg taataatagc   5100

accgattttg ggggagtcgt tccagtagat ggaaagcatc tggaacaggt gtcagcaagc   5160

tcctgccgac gtgtatgcat aaagttttat tgaaaccacc atcgtgtcca tttgtttatg   5220

gcagaactga gagatggcag cagcaagtgt gtgcctgcaa aacctaaaat atttactaat   5280

tggctctgca agaaaagagt ttgcatcccc ctaacctaga acagtgtcta gcctctagta   5340

tgtgtttagc ctacagtatg tgctcagcga atacaatcta tatttattac tgcttttatg   5400

actgttataa ttactgtgct tggatttcgt tacaaagtaa gtcacaatgt gcctgcttct   5460

gttagtattt cagcacagtg cctggcacac atggggctct caaatattgc tgagcgagtg   5520

aacaaatgtc ctttcaattc cttaacgttg atgtcatttt caatagtatt ttgagccaaa   5580

cttaattttg cgagtgtgtt ttgttttctt aactttatta ttaaaaatgt ataaaagtga   5640

ggccaggcgt ggtggctcac gcctgtaatc ccagcagttt gggaggctga ggcaggcgga   5700

tcagttgagg ttgggagttg gagaccagcc cgtccaacat ggtgaaagcc tgtctctact   5760

aaaaatacaa aaatcagctg ggtgtggtgg cgcgtgcctg taatcccagc tactcaggag   5820

gctgaggcag gagagttgct tgaatcctag aggtggaggt tgcagtgagc tgagatcgtg   5880

ccattgcact ccagcctggg caacaagagc aaaactctgt cccaataaat aaataaataa   5940

aatgttctct tttgttcctg ttcttgtgcg gtagtgtggt atagagtttt atggtaatta   6000

ctgtgaatta gtgattctga gggacatatc agaactctga ggtttgtttc cttctcatct   6060

tgagggaaac agcaaatgta tgttaaaatg cttttccaag ggaacaacac atccttacat   6120

tatttaaacc aatctgcttc attttcagag ctggttgatc agagtgagtc agaaggcccc   6180

gtgatacaag aatcagctga accaagccag ttggaagttc cagccacaga agaaataaaa   6240

gagactgatg gaagctctca gatcaagcaa gaaccagacc ccacgtggta gacctcttcc   6300

ctcctaggct taaagtatca gtggttgaga agagcttttc ggacctgtta ctaccccaag   6360

ctgtgtaata tacttgtata acagaaatac cttctataca aacctttttt tctactttta   6420

gatagaaatg tctacttttt cagcagttct gtgaattaaa gagcagagtg actgtgggtc   6480

tggaatggct ggtgtacttg ggaatgtact atcaggattt tacagcaatg ctgggaaatg   6540

acagggaaaa tgacaggaat gaatctcacc agatttttta tgtactcagc agagccttga   6600

gttacggtgt ttattttcca atcaagtgaa gatatctcct acttctccta ctggaacatc   6660

tcagcttctg cagtgaagaa aaattcctgt gatagttcag ttctttagtt tttctatttg   6720

aaaaaaaaaa atcatttaaa tgatcctttg ttcacggctc tccttaatga ctgagtgaac   6780

agttcctatc tgtatatttg actaaacctt ttcctaagct atctctcatg gttcctatgt   6840

ttttttatca taattaaaag caaaaccatc tggatcacct aacagtcaga ggtcagtatc   6900

tcagcgtgtg aattatagag gaaatacaga gagaacctct tccactttta cttttcgtcc   6960

aaataaaatg catggtgtac cagaagttga agatcgggtt gaggattggg gctagctcga   7020

tgacactaag gccccaacat cgcgggacct gctgtggcgc ggattcttag gaacgctgtt   7080

ctagccggcc ccctctccag gggtcgccgt ggccggcatt atttcctagt tcttcttgta   7140

accctgaggt gccagcgcgg ggagtgagga ggggtcaggg ggctaaggat gcaacctctg   7200

acgttctgcg ccttcctagg agagtcttac atgtgttgag atttcacaag caatgcgagt   7260

tgtaaaatac cagctctaca agaagctagg ctctgtgacg gcatagtttt cagtagcttt   7320

atcacaatat tcacaatgga gaattatatg acatggtagc agaaataggc ccttttatgt   7380

gttgcttcta ttttacctca aattgtagat atagggtaat caataaaatc catccatgcc   7440

tttcacacac taagt                                                    7455


<210>  4959
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  4959

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala 
            580


<210>  4960
<211>  5043
<212>  DNA
<213>  Homo sapiens

<400>  4960
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg   1020

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040

taccatatcc tgtgtttgaa tcaaacccgg agttcttgaa aggatcgtcc gcgggagtaa   2100

taaaatcaag ttcgttgtta aaaaacctga actagttatt tcctacttgc ctcctgggat   2160

ggctagtaaa ataaacacta aagctttgca gtcccccaaa agaccacgaa gtcctgggag   2220

taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc cctaataaca acaatcctca   2280

aacctcagct gttcgaaccc cgacccagac taacggttct aacgttccct tcaagccacg   2340

agggagagag ttttcctttg aggcctggaa tgccaaaatc acggacctaa aacagaaagt   2400

tgaaaatctc ttcaatgaga aatgtgggga agctcttggc cttaaacaag ctgtgaaggt   2460

gccgttcgcg ttatttgagt ctttcccgga agacttttat gtggaaggct tacctgaggg   2520

tgtgccattc cgaagaccat cgacttttgg cattccgagg ctggagaaga tactcagaaa   2580

caaagccaaa attaagttca tcattaaaaa gcccgaaatg tttgagacgg cgattaagga   2640

gagcacctcc tctaagagcc ctcccagaaa aataaattca tcacccaatg ttaatactac   2700

tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca attccagatg atgataatga   2760

aagactctcg aaagttgaaa aagctagaca gctaagagaa caagtgaatg acctctttag   2820

tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg aaagttccct acaggaaaat   2880

cacaattaac cctggctgtg tggtggttga tggcatgccc ccgggggtgt ccttcaaagc   2940

ccccagctac ctggaaatca gctccatgag aaggatctta gactctgccg agtttatcaa   3000

attcacggtc attagaccat ttccaggact tgtgattaat aaccagctgg ttgatcagag   3060

tgagtcagaa ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc   3120

cacagaagaa ataaaagaga ctgatggaag ctctcagatc aagcaagaac cagaccccac   3180

gtggtagacc tcttccctcc tagggtaaat cagcttctgt gtcagggatg ctgtgtggtg   3240

tccatctgaa ccccctgcat acgcgtagct aatgtgatct ccccactttc acataagatg   3300

gtggccctgc cttcagggaa tgtgggagcc aggtgggagc cttcccggat atttaagcta   3360

gaagattcta cagggagatt ctccttggat caatatatgt ctctcagtca aagatgtaaa   3420

agcacttttg ccttaaaaag aatgttctgt ttctaaatag agtcaacgtt gtcctcctca   3480

ttggaattca ctatgagtca gaatcattag actgactttt ttttttccat agtaatagta   3540

ttttgcagag tctcacagag ctgcagatct tttgttcatc ttgcagagtt aacaagtctg   3600

atcctgttag tccagatttc ttaaatttgg ccaagttata ataggagcag tagcttgaga   3660

cccgaagtca ggaaactttg acaatggatt ttttttttta atccagagac ttgtactgga   3720

atttgcctta ccctgtcagc tcatggactt aaggtttcat cccgctttat gagtgcttct   3780

gaatccaagt cattgttacc tgaatttgca aattaagttg tgatattcgt gactgttaaa   3840

ttcctgtaat tagattaacc tctttgcttg cttgtttgtt ttctctccta ttttagctta   3900

aagtatcagt ggttgagaag agcttttcgg acctgttact accccaagct gtgtaatata   3960

cttgtataac agaaatacct tctatacaaa cctttttttc tacttttaga tagaaatgtc   4020

tactttttca gcagttctgt gaattaaaga gcagagtgac tgtgggtctg gaatggctgg   4080

tgtacttggg aatgtactat caggatttta cagcaatgct gggaaatgac agggaaaatg   4140

acaggaatga atctcaccag attttttatg tactcagcag agccttgagt tacggtgttt   4200

attttccaat caagtgaaga tatctcctac ttctcctact ggaacatctc agcttctgca   4260

gtgaagaaaa attcctgtga tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat   4320

catttaaatg atcctttgtt cacggctctc cttaatgact gagtgaacag ttcctatctg   4380

tatatttgac taaacctttt cctaagctat ctctcatggt tcctatgttt ttttatcata   4440

attaaaagca aaaccatctg gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa   4500

ttatagagga aatacagaga gaacctcttc cacttttact tttcgtccaa ataaaatgca   4560

tggtgtacca gaagttgaag atcgggttga ggattggggc tagctcgatg acactaaggc   4620

cccaacatcg cgggacctgc tgtggcgcgg attcttagga acgctgttct agccggcccc   4680

ctctccaggg gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac cctgaggtgc   4740

cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc   4800

ttcctaggag agtcttacat gtgttgagat ttcacaagca atgcgagttg taaaatacca   4860

gctctacaag aagctaggct ctgtgacggc atagttttca gtagctttat cacaatattc   4920

acaatggaga attatatgac atggtagcag aaataggccc ttttatgtgt tgcttctatt   4980

ttacctcaaa ttgtagatat agggtaatca ataaaatcca tccatgcctt tcacacacta   5040

agt                                                                 5043


<210>  4961
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  4961

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ile Ser Leu Glu 
    130                 135                 140


Met Ala Ala Val Thr Val Lys Glu Glu Ser Glu Asp Pro Asp Tyr Tyr 
145                 150                 155                 160


Gln Tyr Asn Ile Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly 
                165                 170                 175


Thr Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser 
            180                 185                 190


Glu Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp 
        195                 200                 205


Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro 
    210                 215                 220


Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe 
225                 230                 235                 240


Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val 
                245                 250                 255


Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly 
            260                 265                 270


Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu 
        275                 280                 285


Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr 
    290                 295                 300


Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile 
305                 310                 315                 320


Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp 
                325                 330                 335


Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala 
            340                 345                 350


Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys 
        355                 360                 365


Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln 
    370                 375                 380


Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu 
385                 390                 395                 400


Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu 
                405                 410                 415


Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro 
            420                 425                 430


Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn 
        435                 440                 445


Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys 
    450                 455                 460


Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu 
465                 470                 475                 480


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
                485                 490                 495


Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu 
            500                 505                 510


Lys Asn Leu Asn 
        515


<210>  4962
<211>  5248
<212>  DNA
<213>  Homo sapiens

<400>  4962
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggaag ccaccattct tcagagggca atgaaggcac   1140

agaaatggaa gtaccagcag aagattctac tcaacatgtc ccttcagaaa caagtgagga   1200

ccctgaagtt gaggtgacta ttgaagatga tgattattct ccaccgtcta agagaccaaa   1260

ggccaatgag ctaccgcagc caccagtccc ggaacccgcc aatgctggga agcggaaagt   1320

gagggagttc aacttcgaga aatggaatgc tcgcatcact gatctacgta aacaagttga   1380

agaattgttt gaaaggaaat atgctcaagc cataaaagcc aaaggtccgg tgacgatccc   1440

gtaccctctt ttccagtctc atgttgaaga tctttatgta gaaggacttc ctgaaggaat   1500

tccttttaga aggccatcta cttacggaat tcctcgcctg gagaggatat tacttgcaaa   1560

ggaaaggatt cgttttgtga ttaagaaaca tgagcttctg aattcaacac gtgaagattt   1620

acagcttgat aagccagctt caggagtaaa ggaagaatgg tatgccagaa tcactaaatt   1680

aagaaagatg gtggatcagc ttttctgcaa aaaatttgcg gaagccttgg ggagcactga   1740

agccaaggct gtaccgtacc aaaaatttga ggcacacccg aatgatctgt acgtggaagg   1800

actgccagaa aacattcctt tccgaagtcc ctcatggtat ggaatcccaa ggctggaaaa   1860

aatcattcaa gtgggcaatc gaattaaatt tgttattaaa agaccagaac ttctgactca   1920

cagtaccact gaagttactc agccaagaac gaatacacca gtcaaagaag attggaatgt   1980

cagaattacc aagctacgga agcaagtgga agagattttt aatttgaaat ttgcttagat   2040

ttgttgacag cggtttcctg gagtgctgtc ttgagaacga ttctgaggag gctcagcaag   2100

aaagagtgtt tcagttgatt gggtgtgtct gtcatggaga aggaactcaa gctcttggac   2160

tcaccgaggc agtaaaagta ccatatcctg tgtttgaatc aaacccggag ttcttgtatg   2220

tggaaggctt gccagagggg attcccttcc gaagccctac ctggtttgga attccacgac   2280

ttgaaaggat cgtccgcggg agtaataaaa tcaagttcgt tgttaaaaaa cctgaactag   2340

ttatttccta cttgcctcct gggatggcta gtaaaataaa cactaaagct ttgcagtccc   2400

ccaaaagacc acgaagtcct gggagtaatt caaaggttcc tgaaattgag gtcaccgtgg   2460

aaggccctaa taacaacaat cctcaaacct cagctgttcg aaccccgacc cagactaacg   2520

gttctaacgt tcccttcaag ccacgaggga gagagttttc ctttgaggcc tggaatgcca   2580

aaatcacgga cctaaaacag aaagttgaaa atctcttcaa tgagaaatgt ggggaagctc   2640

ttggccttaa acaagctgtg aaggtgccgt tcgcgttatt tgagtctttc ccggaagact   2700

tttatgtgga aggcttacct gagggtgtgc cattccgaag accatcgact tttggcattc   2760

cgaggctgga gaagatactc agaaacaaag ccaaaattaa gttcatcatt aaaaagcccg   2820

aaatgtttga gacggcgatt aaggagagca cctcctctaa gagccctccc agaaaaataa   2880

attcatcacc caatgttaat actactgcat caggtgttga agaccttaac atcattcagg   2940

tgacaattcc agatgatgat aatgaaagac tctcgaaagt tgaaaaagct agacagctaa   3000

gagaacaagt gaatgacctc tttagtcgga aatttggtga agctattggt atgggttttc   3060

ctgtgaaagt tccctacagg aaaatcacaa ttaaccctgg ctgtgtggtg gttgatggca   3120

tgcccccggg ggtgtccttc aaagccccca gctacctgga aatcagctcc atgagaagga   3180

tcttagactc tgccgagttt atcaaattca cggtcattag accatttcca ggacttgtga   3240

ttaataacca gctggttgat cagagtgagt cagaaggccc cgtgatacaa gaatcagctg   3300

aaccaagcca gttggaagtt ccagccacag aagaaataaa agagactgat ggaagctctc   3360

agatcaagca agaaccagac cccacgtggt agacctcttc cctcctaggg taaatcagct   3420

tctgtgtcag ggatgctgtg tggtgtccat ctgaaccccc tgcatacgcg tagctaatgt   3480

gatctcccca ctttcacata agatggtggc cctgccttca gggaatgtgg gagccaggtg   3540

ggagccttcc cggatattta agctagaaga ttctacaggg agattctcct tggatcaata   3600

tatgtctctc agtcaaagat gtaaaagcac ttttgcctta aaaagaatgt tctgtttcta   3660

aatagagtca acgttgtcct cctcattgga attcactatg agtcagaatc attagactga   3720

cttttttttt tccatagtaa tagtattttg cagagtctca cagagctgca gatcttttgt   3780

tcatcttgca gagttaacaa gtctgatcct gttagtccag atttcttaaa tttggccaag   3840

ttataatagg agcagtagct tgagacccga agtcaggaaa ctttgacaat ggattttttt   3900

ttttaatcca gagacttgta ctggaatttg ccttaccctg tcagctcatg gacttaaggt   3960

ttcatcccgc tttatgagtg cttctgaatc caagtcattg ttacctgaat ttgcaaatta   4020

agttgtgata ttcgtgactg ttaaattcct gtaattagat taacctcttt gcttgcttgt   4080

ttgttttctc tcctatttta gcttaaagta tcagtggttg agaagagctt ttcggacctg   4140

ttactacccc aagctgtgta atatacttgt ataacagaaa taccttctat acaaaccttt   4200

ttttctactt ttagatagaa atgtctactt tttcagcagt tctgtgaatt aaagagcaga   4260

gtgactgtgg gtctggaatg gctggtgtac ttgggaatgt actatcagga ttttacagca   4320

atgctgggaa atgacaggga aaatgacagg aatgaatctc accagatttt ttatgtactc   4380

agcagagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct cctacttctc   4440

ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta   4500

gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg ctctccttaa   4560

tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa gctatctctc   4620

atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca cctaacagtc   4680

agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc tcttccactt   4740

ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg gttgaggatt   4800

ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg cgcggattct   4860

taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc attatttcct   4920

agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca gggggctaag   4980

gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt gagatttcac   5040

aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg acggcatagt   5100

tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt agcagaaata   5160

ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt aatcaataaa   5220

atccatccat gcctttcaca cactaagt                                      5248


<210>  4963
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  4963

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535


<210>  4964
<211>  5033
<212>  DNA
<213>  Homo sapiens

<400>  4964
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gatgatgatt attctccacc   1260

gtctaagaga ccaaaggcca atgagctacc gcagccacca gtcccggaac ccgccaatgc   1320

tgggaagcgg aaagtgaggg agttcaactt cgagaaatgg aatgctcgca tcactgatct   1380

acgtaaacaa gttgaagaat tgtttgaaag gaaatatgct caagccataa aagccaaagg   1440

tccggtgacg atcccgtacc ctcttttcca gtctcatgtt gaagatcttt atgtagaagg   1500

acttcctgaa ggaattcctt ttagaaggcc atctacttac ggaattcctc gcctggagag   1560

gatattactt gcaaaggaaa ggattcgttt tgtgattaag aaacatgagc ttctgaattc   1620

aacacgtgaa gatttacagc ttgataagcc agcttcagga gtaaaggaag aatggtatgc   1680

cagaatcact aaattaagaa agatggtgga tcagcttttc tgcaaaaaat ttgcggaagc   1740

cttggggagc actgaagcca aggctgtacc gtaccaaaaa tttgaggcac acccgaatga   1800

tctgtacgtg gaaggactgc cagaaaacat tcctttccga agtccctcat ggtatggaat   1860

cccaaggctg gaaaaaatca ttcaagtggg caatcgaatt aaatttgtta ttaaaagacc   1920

agaacttctg actcacagta ccactgaagt tactcagcca agaacgaata caccagtcaa   1980

agaagattgg aatgtcagaa ttaccaagct acggaagcaa gtggaagaga tttttaattt   2040

gaaatttgct caagctcttg gactcaccga ggcagtaaaa gtaccatatc ctgtgtttga   2100

atcaaacccg gagttcttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2160

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2220

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2280

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2340

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2400

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2460

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2520

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2580

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2640

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2700

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2760

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2820

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2880

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   2940

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3000

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca   3060

tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg   3120

atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaagg taaaaggacc   3180

tcttccctcc tagggtaaat cagcttctgt gtcagggatg ctgtgtggtg tccatctgaa   3240

ccccctgcat acgcgtagct aatgtgatct ccccactttc acataagatg gtggccctgc   3300

cttcagggaa tgtgggagcc aggtgggagc cttcccggat atttaagcta gaagattcta   3360

cagggagatt ctccttggat caatatatgt ctctcagtca aagatgtaaa agcacttttg   3420

ccttaaaaag aatgttctgt ttctaaatag agtcaacgtt gtcctcctca ttggaattca   3480

ctatgagtca gaatcattag actgactttt ttttttccat agtaatagta ttttgcagag   3540

tctcacagag ctgcagatct tttgttcatc ttgcagagtt aacaagtctg atcctgttag   3600

tccagatttc ttaaatttgg ccaagttata ataggagcag tagcttgaga cccgaagtca   3660

ggaaactttg acaatggatt ttttttttta atccagagac ttgtactgga atttgcctta   3720

ccctgtcagc tcatggactt aaggtttcat cccgctttat gagtgcttct gaatccaagt   3780

cattgttacc tgaatttgca aattaagttg tgatattcgt gactgttaaa ttcctgtaat   3840

tagattaacc tctttgcttg cttgtttgtt ttctctccta ttttagctta aagtatcagt   3900

ggttgagaag agcttttcgg acctgttact accccaagct gtgtaatata cttgtataac   3960

agaaatacct tctatacaaa cctttttttc tacttttaga tagaaatgtc tactttttca   4020

gcagttctgt gaattaaaga gcagagtgac tgtgggtctg gaatggctgg tgtacttggg   4080

aatgtactat caggatttta cagcaatgct gggaaatgac agggaaaatg acaggaatga   4140

atctcaccag attttttatg tactcagcag agccttgagt tacggtgttt attttccaat   4200

caagtgaaga tatctcctac ttctcctact ggaacatctc agcttctgca gtgaagaaaa   4260

attcctgtga tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat catttaaatg   4320

atcctttgtt cacggctctc cttaatgact gagtgaacag ttcctatctg tatatttgac   4380

taaacctttt cctaagctat ctctcatggt tcctatgttt ttttatcata attaaaagca   4440

aaaccatctg gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa ttatagagga   4500

aatacagaga gaacctcttc cacttttact tttcgtccaa ataaaatgca tggtgtacca   4560

gaagttgaag atcgggttga ggattggggc tagctcgatg acactaaggc cccaacatcg   4620

cgggacctgc tgtggcgcgg attcttagga acgctgttct agccggcccc ctctccaggg   4680

gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg   4740

agtgaggagg ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc ttcctaggag   4800

agtcttacat gtgttgagat ttcacaagca atgcgagttg taaaatacca gctctacaag   4860

aagctaggct ctgtgacggc atagttttca gtagctttat cacaatattc acaatggaga   4920

attatatgac atggtagcag aaataggccc ttttatgtgt tgcttctatt ttacctcaaa   4980

ttgtagatat agggtaatca ataaaatcca tccatgcctt tcacacacta agt          5033


<210>  4965
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  4965

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
                565                 570                 575


Ser Ser Leu Leu Lys Asn Leu Asn 
            580


<210>  4966
<211>  4515
<212>  DNA
<213>  Homo sapiens

<400>  4966
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2100

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2160

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2220

tgaatcaaac ccggagttct tgaaaggatc gtccgcggga gtaataaaat caagttcgtt   2280

gttaaaaaac ctgaactagt tatttcctac ttgcctcctg ggatggctag taaaataaac   2340

actaaagctt tgcagtcccc caaaagacca cgaagtcctg ggagtaattc aaaggttcct   2400

gaaattgagg tcaccgtgga aggccctaat aacaacaatc ctcaaacctc agctgttcga   2460

accccgaccc agactaacgg ttctaacgtt cccttcaagc cacgagggag agagttttcc   2520

tttgaggcct ggaatgccaa aatcacggac ctaaaacaga aagttgaaaa tctcttcaat   2580

gagaaatgtg gggaagctct tggccttaaa caagctgtga aggtgccgtt cgcgttattt   2640

gagtctttcc cggaagactt ttatgtggaa ggcttacctg agggtgtgcc attccgaaga   2700

ccatcgactt ttggcattcc gaggctggag aagatactca gaaacaaagc caaaattaag   2760

ttcatcatta aaaagcccga aatgtttgag acggcgatta aggagagcac ctcctctaag   2820

agccctccca gaaaaataaa ttcatcaccc aatgttaata ctactgcatc aggtgttgaa   2880

gaccttaaca tcattcaggt gacaattcca gatgatgata atgaaagact ctcgaaagtt   2940

gaaaaagcta gacagctaag agaacaagtg aatgacctct ttagtcggaa atttggtgaa   3000

gctattggta tgggttttcc tgtgaaagtt ccctacagga aaatcacaat taaccctggc   3060

tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca aagcccccag ctacctggaa   3120

atcagctcca tgagaaggat cttagactct gccgagttta tcaaattcac ggtcattaga   3180

ccatttccag gacttgtgat taataaccag ctggttgatc agagtgagtc agaaggcccc   3240

gtgatacaag aatcagctga accaagccag ttggaagttc cagccacaga agaaataaaa   3300

gagactgatg gaagctctca gatcaagcaa gaaccagacc ccacgtggta gacctcttcc   3360

ctcctaggct taaagtatca gtggttgaga agagcttttc ggacctgtta ctaccccaag   3420

ctgtgtaata tacttgtata acagaaatac cttctataca aacctttttt tctactttta   3480

gatagaaatg tctacttttt cagcagttct gtgaattaaa gagcagagtg actgtgggtc   3540

tggaatggct ggtgtacttg ggaatgtact atcaggattt tacagcaatg ctgggaaatg   3600

acagggaaaa tgacaggaat gaatctcacc agatttttta tgtactcagc agagccttga   3660

gttacggtgt ttattttcca atcaagtgaa gatatctcct acttctccta ctggaacatc   3720

tcagcttctg cagtgaagaa aaattcctgt gatagttcag ttctttagtt tttctatttg   3780

aaaaaaaaaa atcatttaaa tgatcctttg ttcacggctc tccttaatga ctgagtgaac   3840

agttcctatc tgtatatttg actaaacctt ttcctaagct atctctcatg gttcctatgt   3900

ttttttatca taattaaaag caaaaccatc tggatcacct aacagtcaga ggtcagtatc   3960

tcagcgtgtg aattatagag gaaatacaga gagaacctct tccactttta cttttcgtcc   4020

aaataaaatg catggtgtac cagaagttga agatcgggtt gaggattggg gctagctcga   4080

tgacactaag gccccaacat cgcgggacct gctgtggcgc ggattcttag gaacgctgtt   4140

ctagccggcc ccctctccag gggtcgccgt ggccggcatt atttcctagt tcttcttgta   4200

accctgaggt gccagcgcgg ggagtgagga ggggtcaggg ggctaaggat gcaacctctg   4260

acgttctgcg ccttcctagg agagtcttac atgtgttgag atttcacaag caatgcgagt   4320

tgtaaaatac cagctctaca agaagctagg ctctgtgacg gcatagtttt cagtagcttt   4380

atcacaatat tcacaatgga gaattatatg acatggtagc agaaataggc ccttttatgt   4440

gttgcttcta ttttacctca aattgtagat atagggtaat caataaaatc catccatgcc   4500

tttcacacac taagt                                                    4515


<210>  4967
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  4967

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys 
        595                 600                 605


Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu 
    610                 615                 620


Asn 
625


<210>  4968
<211>  4056
<212>  DNA
<213>  Homo sapiens

<400>  4968
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggtgta    420

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    480

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    540

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    600

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    660

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    720

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    780

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    840

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    900

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    960

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag   1020

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1080

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1140

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1200

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1260

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1320

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1380

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1440

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1500

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1560

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1620

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1680

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1740

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1800

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1860

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1920

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1980

aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc   2040

ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt   2100

tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa   2160

taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg   2220

ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg   2280

ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga gggagagagt   2340

tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct   2400

tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt   2460

tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc   2520

gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa   2580

ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct   2640

ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg   2700

ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga   2760

aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg   2820

gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc   2880

ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc   2940

tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca   3000

ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt gagtcagaag   3060

gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc acagaagaaa   3120

taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg tggtagacct   3180

cttccctcct aggagccttg agttacggtg tttattttcc aatcaagtga agatatctcc   3240

tacttctcct actggaacat ctcagcttct gcagtgaaga aaaattcctg tgatagttca   3300

gttctttagt ttttctattt gaaaaaaaaa aatcatttaa atgatccttt gttcacggct   3360

ctccttaatg actgagtgaa cagttcctat ctgtatattt gactaaacct tttcctaagc   3420

tatctctcat ggttcctatg tttttttatc ataattaaaa gcaaaaccat ctggatcacc   3480

taacagtcag aggtcagtat ctcagcgtgt gaattataga ggaaatacag agagaacctc   3540

ttccactttt acttttcgtc caaataaaat gcatggtgta ccagaagttg aagatcgggt   3600

tgaggattgg ggctagctcg atgacactaa ggccccaaca tcgcgggacc tgctgtggcg   3660

cggattctta ggaacgctgt tctagccggc cccctctcca ggggtcgccg tggccggcat   3720

tatttcctag ttcttcttgt aaccctgagg tgccagcgcg gggagtgagg aggggtcagg   3780

gggctaagga tgcaacctct gacgttctgc gccttcctag gagagtctta catgtgttga   3840

gatttcacaa gcaatgcgag ttgtaaaata ccagctctac aagaagctag gctctgtgac   3900

ggcatagttt tcagtagctt tatcacaata ttcacaatgg agaattatat gacatggtag   3960

cagaaatagg cccttttatg tgttgcttct attttacctc aaattgtaga tatagggtaa   4020

tcaataaaat ccatccatgc ctttcacaca ctaagt                             4056


<210>  4969
<211>  863
<212>  PRT
<213>  Homo sapiens

<400>  4969

Met His Lys Met Lys Ser Thr Thr Gln Ala Asn Arg Met Ser Val Asp 
1               5                   10                  15


Ala Val Glu Ile Glu Thr Leu Arg Lys Thr Val Glu Asp Tyr Phe Cys 
            20                  25                  30


Phe Cys Tyr Gly Lys Ala Leu Gly Lys Ser Thr Val Val Pro Val Pro 
        35                  40                  45


Tyr Glu Lys Met Leu Arg Asp Gln Ser Ala Val Val Val Gln Gly Leu 
    50                  55                  60


Pro Glu Gly Val Ala Phe Lys His Pro Glu Asn Tyr Asp Leu Ala Thr 
65                  70                  75                  80


Leu Lys Trp Ile Leu Glu Asn Lys Ala Gly Ile Ser Phe Ile Ile Lys 
                85                  90                  95


Arg Pro Phe Leu Glu Pro Lys Lys His Val Gly Gly Arg Val Met Val 
            100                 105                 110


Thr Asp Ala Asp Arg Ser Ile Leu Ser Pro Gly Gly Ser Cys Gly Pro 
        115                 120                 125


Ile Lys Val Lys Thr Glu Pro Thr Glu Asp Ser Gly Ser His His Ser 
    130                 135                 140


Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala Glu Asp Ser 
145                 150                 155                 160


Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu Val Glu Val 
                165                 170                 175


Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala 
            180                 185                 190


Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys 
        195                 200                 205


Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr 
    210                 215                 220


Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln 
225                 230                 235                 240


Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln 
                245                 250                 255


Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
            260                 265                 270


Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu 
        275                 280                 285


Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu 
    290                 295                 300


Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val 
305                 310                 315                 320


Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp 
                325                 330                 335


Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala 
            340                 345                 350


Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr 
        355                 360                 365


Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr 
    370                 375                 380


Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys 
385                 390                 395                 400


Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val 
                405                 410                 415


Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg 
            420                 425                 430


Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe 
        435                 440                 445


Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val 
    450                 455                 460


Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly 
465                 470                 475                 480


Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg 
                485                 490                 495


Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu 
            500                 505                 510


Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr 
        515                 520                 525


Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser 
    530                 535                 540


Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn 
545                 550                 555                 560


Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn 
                565                 570                 575


Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn 
            580                 585                 590


Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu 
        595                 600                 605


Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe 
    610                 615                 620


Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro 
625                 630                 635                 640


Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu 
                645                 650                 655


Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys 
            660                 665                 670


Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser 
        675                 680                 685


Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser 
    690                 695                 700


Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp 
705                 710                 715                 720


Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln 
                725                 730                 735


Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly 
            740                 745                 750


Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys 
        755                 760                 765


Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser 
    770                 775                 780


Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe 
785                 790                 795                 800


Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn 
                805                 810                 815


Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser 
            820                 825                 830


Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu 
        835                 840                 845


Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
    850                 855                 860


<210>  4970
<211>  7271
<212>  DNA
<213>  Homo sapiens

<400>  4970
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagc   2100

tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg aatcaaaccc   2160

ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc ctacctggtt   2220

tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt tcgttgttaa   2280

aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa taaacactaa   2340

agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg ttcctgaaat   2400

tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg ttcgaacccc   2460

gacccagact aacggttcta acgttccctt caagccacga gggagagagt tttcctttga   2520

ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct tcaatgagaa   2580

atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt tatttgagtc   2640

tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc gaagaccatc   2700

gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa ttaagttcat   2760

cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct ctaagagccc   2820

tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg ttgaagacct   2880

taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga aagttgaaaa   2940

agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg gtgaagctat   3000

tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc ctggctgtgt   3060

ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc tggaaatcag   3120

ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca ttaggtaagt   3180

gagagtttcc tgcttagtca caggagcgaa tctggagctc atgaggctga ctcttctaaa   3240

atgcagccac aggtagtcat cgaatccggc ttcctatgct gtgcaatcaa caaatcaaaa   3300

taacttgtgt catcattaga atgtcagatg tgcttctacg aactaagctg actcttttaa   3360

ttctttggca aagggttggc aaactaggac tgtttgccaa attcaggctg cctcctattt   3420

ttagagtctt cctgaaacac agctacaccc gtattatcca tggctgcttt cctgtcacag   3480

tgagtaagta gctgggactg agaaggcatg gcctccaaag tctaaaatat ttactctcta   3540

gcactttgta gaaaaacctt agctaggcac agtggctaac gcctgtaatc ccagcatttt   3600

gggaggccaa ggcaggcaga tcacctgagg tcaggagttc cagaccagcc tggccaacat   3660

ggtgaaatcc catctctaca aaaataaaac agttagctgg gcatgatggc gggtgcctgt   3720

aatcccagct actcgggagg ctgaggcagg atagtcgctt gaacccagga ggtggaggtt   3780

gcaatgagcc aagatcatgc cactgcactc cagcctggac gacagagtga gactccatca   3840

caagaaaaaa agaactttgt caacctctgt cttagggcgc cttgtcacag gcttcgggtc   3900

agacggattc aaccttgcat cagccatttg ttagccaggt cactctgttc tttgtctgta   3960

aatgagattg atcgttgttc ccactgagag tgtcagctcc ttcccgtaga gcaggcatga   4020

tgattgtact cacctctgac accattgtga gtgccacatt ccttcccacg tccttgtcac   4080

tgtaagagat gcccacctga gcaccaaccc caggttatct tcccctttgt cttccagccc   4140

cccagaaaca gctacgactc aacctaccca atcatttcat catcagattg ccactgtctc   4200

tagttcaggt ctcttgggac tggcactcag aaatctcata ataaatcctc ttgaggcttc   4260

tcatacactc gtcttcttcc aatcttcttt ccctcaaaat ctcatatttt ggttccactt   4320

cacccaccgt cattctccat atcactccca ggagttaggc aaaaagcccc ttccgttctt   4380

ccgtatgtta aacttagaat cactctgttc cctgctctgc gtttctattt tttgtttttc   4440

ctccatttac tagtagctta acactttcta acagtgttct tattattgat acgtatctat   4500

ctcttccata agcttataag gtcacggata atacttctca ttgtagtacg taaatgacgt   4560

gggctagata tgagttgaat aaacagttat acctgtaaat tcttacagag tgaaaataaa   4620

ttgttatact ttacaatttg tttctctctt tagaccattt ccaggacttg tgattaataa   4680

ccgtgagtat tttgtgaagt gttttgtttt tgttttttcc tggggtctga cgtgtgtgcg   4740

tgtgagtgtg tatacatgct taacgtatat cacgttactt cacctatgtc agtaaccagg   4800

ccaaatactt gttttagccc tcagtaaaaa caccaggcac ttcctagttg taaaattatt   4860

caagcttctt aacttcctat cctcgatgca cttaatcata aaatggtaat aatagcaccg   4920

attttggggg agtcgttcca gtagatggaa agcatctgga acaggtgtca gcaagctcct   4980

gccgacgtgt atgcataaag ttttattgaa accaccatcg tgtccatttg tttatggcag   5040

aactgagaga tggcagcagc aagtgtgtgc ctgcaaaacc taaaatattt actaattggc   5100

tctgcaagaa aagagtttgc atccccctaa cctagaacag tgtctagcct ctagtatgtg   5160

tttagcctac agtatgtgct cagcgaatac aatctatatt tattactgct tttatgactg   5220

ttataattac tgtgcttgga tttcgttaca aagtaagtca caatgtgcct gcttctgtta   5280

gtatttcagc acagtgcctg gcacacatgg ggctctcaaa tattgctgag cgagtgaaca   5340

aatgtccttt caattcctta acgttgatgt cattttcaat agtattttga gccaaactta   5400

attttgcgag tgtgttttgt tttcttaact ttattattaa aaatgtataa aagtgaggcc   5460

aggcgtggtg gctcacgcct gtaatcccag cagtttggga ggctgaggca ggcggatcag   5520

ttgaggttgg gagttggaga ccagcccgtc caacatggtg aaagcctgtc tctactaaaa   5580

atacaaaaat cagctgggtg tggtggcgcg tgcctgtaat cccagctact caggaggctg   5640

aggcaggaga gttgcttgaa tcctagaggt ggaggttgca gtgagctgag atcgtgccat   5700

tgcactccag cctgggcaac aagagcaaaa ctctgtccca ataaataaat aaataaaatg   5760

ttctcttttg ttcctgttct tgtgcggtag tgtggtatag agttttatgg taattactgt   5820

gaattagtga ttctgaggga catatcagaa ctctgaggtt tgtttccttc tcatcttgag   5880

ggaaacagca aatgtatgtt aaaatgcttt tccaagggaa caacacatcc ttacattatt   5940

taaaccaatc tgcttcattt tcagagctgg ttgatcagag tgagtcagaa ggccccgtga   6000

tacaagaatc agctgaacca agccagttgg aagttccagc cacagaagaa ataaaagaga   6060

ctgatggaag ctctcagatc aagcaagaac cagaccccac gtggtagacc tcttccctcc   6120

taggcttaaa gtatcagtgg ttgagaagag cttttcggac ctgttactac cccaagctgt   6180

gtaatatact tgtataacag aaataccttc tatacaaacc tttttttcta cttttagata   6240

gaaatgtcta ctttttcagc agttctgtga attaaagagc agagtgactg tgggtctgga   6300

atggctggtg tacttgggaa tgtactatca ggattttaca gcaatgctgg gaaatgacag   6360

ggaaaatgac aggaatgaat ctcaccagat tttttatgta ctcagcagag ccttgagtta   6420

cggtgtttat tttccaatca agtgaagata tctcctactt ctcctactgg aacatctcag   6480

cttctgcagt gaagaaaaat tcctgtgata gttcagttct ttagtttttc tatttgaaaa   6540

aaaaaaatca tttaaatgat cctttgttca cggctctcct taatgactga gtgaacagtt   6600

cctatctgta tatttgacta aaccttttcc taagctatct ctcatggttc ctatgttttt   6660

ttatcataat taaaagcaaa accatctgga tcacctaaca gtcagaggtc agtatctcag   6720

cgtgtgaatt atagaggaaa tacagagaga acctcttcca cttttacttt tcgtccaaat   6780

aaaatgcatg gtgtaccaga agttgaagat cgggttgagg attggggcta gctcgatgac   6840

actaaggccc caacatcgcg ggacctgctg tggcgcggat tcttaggaac gctgttctag   6900

ccggccccct ctccaggggt cgccgtggcc ggcattattt cctagttctt cttgtaaccc   6960

tgaggtgcca gcgcggggag tgaggagggg tcagggggct aaggatgcaa cctctgacgt   7020

tctgcgcctt cctaggagag tcttacatgt gttgagattt cacaagcaat gcgagttgta   7080

aaataccagc tctacaagaa gctaggctct gtgacggcat agttttcagt agctttatca   7140

caatattcac aatggagaat tatatgacat ggtagcagaa ataggccctt ttatgtgttg   7200

cttctatttt acctcaaatt gtagatatag ggtaatcaat aaaatccatc catgcctttc   7260

acacactaag t                                                        7271


<210>  4971
<211>  918
<212>  PRT
<213>  Homo sapiens

<400>  4971

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala 
545                 550                 555                 560


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
                565                 570                 575


Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile 
            580                 585                 590


Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile 
        595                 600                 605


Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu 
    610                 615                 620


Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys 
625                 630                 635                 640


Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys 
                645                 650                 655


Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro 
            660                 665                 670


Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val 
        675                 680                 685


Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala 
    690                 695                 700


Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys 
705                 710                 715                 720


Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala 
                725                 730                 735


Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu 
            740                 745                 750


Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu 
        755                 760                 765


Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro 
    770                 775                 780


Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro 
785                 790                 795                 800


Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly 
                805                 810                 815


Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn 
            820                 825                 830


Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val 
        835                 840                 845


Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe 
    850                 855                 860


Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val 
865                 870                 875                 880


Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr 
                885                 890                 895


Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile 
            900                 905                 910


Lys Phe Thr Val Ile Arg 
        915


<210>  4972
<211>  4582
<212>  DNA
<213>  Homo sapiens

<400>  4972
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caagcaggcc cttctgaaac   1200

tgatgatgtt gatgaaaaac agcccctatc gaagcctttg caaggaagcc accattcttc   1260

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1320

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1380

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1440

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1500

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1560

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1620

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1680

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1740

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1800

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1860

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1920

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1980

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   2040

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2100

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2160

tttgaaattt gctcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt   2220

tgaatcaaac ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag   2280

ccctacctgg tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa   2340

gttcgttgtt aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa   2400

aataaacact aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa   2460

ggttcctgaa attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc   2520

tgttcgaacc ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga   2580

gttttccttt gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct   2640

cttcaatgag aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc   2700

gttatttgag tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt   2760

ccgaagacca tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa   2820

aattaagttc atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc   2880

ctctaagagc cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg   2940

tgttgaagac cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc   3000

gaaagttgaa aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt   3060

tggtgaagct attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa   3120

ccctggctgt gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta   3180

cctggaaatc agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt   3240

cattagacca tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga   3300

aggccccgtg atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga   3360

aataaaagag actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac   3420

ctcttccctc ctaggcttaa agtatcagtg gttgagaaga gcttttcgga cctgttacta   3480

ccccaagctg tgtaatatac ttgtataaca gaaatacctt ctatacaaac ctttttttct   3540

acttttagat agaaatgtct actttttcag cagttctgtg aattaaagag cagagtgact   3600

gtgggtctgg aatggctggt gtacttggga atgtactatc aggattttac agcaatgctg   3660

ggaaatgaca gggaaaatga caggaatgaa tctcaccaga ttttttatgt actcagcaga   3720

gccttgagtt acggtgttta ttttccaatc aagtgaagat atctcctact tctcctactg   3780

gaacatctca gcttctgcag tgaagaaaaa ttcctgtgat agttcagttc tttagttttt   3840

ctatttgaaa aaaaaaaatc atttaaatga tcctttgttc acggctctcc ttaatgactg   3900

agtgaacagt tcctatctgt atatttgact aaaccttttc ctaagctatc tctcatggtt   3960

cctatgtttt tttatcataa ttaaaagcaa aaccatctgg atcacctaac agtcagaggt   4020

cagtatctca gcgtgtgaat tatagaggaa atacagagag aacctcttcc acttttactt   4080

ttcgtccaaa taaaatgcat ggtgtaccag aagttgaaga tcgggttgag gattggggct   4140

agctcgatga cactaaggcc ccaacatcgc gggacctgct gtggcgcgga ttcttaggaa   4200

cgctgttcta gccggccccc tctccagggg tcgccgtggc cggcattatt tcctagttct   4260

tcttgtaacc ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc taaggatgca   4320

acctctgacg ttctgcgcct tcctaggaga gtcttacatg tgttgagatt tcacaagcaa   4380

tgcgagttgt aaaataccag ctctacaaga agctaggctc tgtgacggca tagttttcag   4440

tagctttatc acaatattca caatggagaa ttatatgaca tggtagcaga aataggccct   4500

tttatgtgtt gcttctattt tacctcaaat tgtagatata gggtaatcaa taaaatccat   4560

ccatgccttt cacacactaa gt                                            4582


<210>  4973
<211>  998
<212>  PRT
<213>  Homo sapiens

<400>  4973

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr 
        595                 600                 605


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe 
    610                 615                 620


Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys 
625                 630                 635                 640


Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly 
                645                 650                 655


Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro 
            660                 665                 670


Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val 
        675                 680                 685


Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro 
    690                 695                 700


Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu 
705                 710                 715                 720


Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys 
                725                 730                 735


Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys 
            740                 745                 750


Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp 
        755                 760                 765


Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser 
    770                 775                 780


Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys 
785                 790                 795                 800


Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys 
                805                 810                 815


Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro 
            820                 825                 830


Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln 
        835                 840                 845


Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys 
    850                 855                 860


Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe 
865                 870                 875                 880


Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys 
                885                 890                 895


Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly 
            900                 905                 910


Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg 
        915                 920                 925


Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe 
    930                 935                 940


Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu 
945                 950                 955                 960


Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro 
                965                 970                 975


Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln 
            980                 985                 990


Glu Pro Asp Pro Thr Trp 
        995


<210>  4974
<211>  4082
<212>  DNA
<213>  Homo sapiens

<400>  4974
aaaaaaaaaa aaaaaaaaaa aaaaaaaaga aaaaagaaaa aaaaaaggag gaggaggagg     60

agggtgagag agaagctggg agagcagaga aaaggggcca ccggtcgccc ccccgcttcc    120

ccgcacgcgc tctccagccg cggccgcccg cctgccgcgg tcaccccggc ctctgcctct    180

gtcccccagt gatcggatca aggcgctgag cgaggccctg cctgcggggc ggccatgcgg    240

cggtgacagg agcgcgaccg acacgcacgg gcccctcgcc ccctctcgcc tcccgtccgc    300

tcgccagctc ccctcagccg aggctgctcc gcggcggccg cagcccgcgc gcggcccaca    360

ctcgcctccc ctcggcaccc ccggccccgg agctgcctgg aggcggccgc actcggggat    420

catggcccaa gttgcaatgt ccaccctccc cgttgaagat gaggagtcct cggagagcag    480

gatggtggtg acattcctca tgtcagctct cgagtccatg tgtaaagaac tggccaagtc    540

caaagccgaa gtggcctgca ttgcagtgta tgaaacagac gtgtttgtcg tcggaactga    600

aagaggacgt gcttttgtca ataccagaaa ggattttcaa aaagattttg taaaatattg    660

tgttgaagaa gaagaaaaag ctgcagagat gcataaaatg aaatctacaa cccaggcaaa    720

tcggatgagt gtagatgctg tagaaattga aacactcaga aaaacagttg aggactattt    780

ctgcttttgc tatgggaaag ctttaggcaa atccacagtg gtacctgtac catatgagaa    840

gatgctgcga gaccagtcgg ctgtggtagt gcaggggctt ccggaaggtg ttgcctttaa    900

acaccccgag aactatgatc ttgcaaccct gaaatggatt ttggagaaca aagcagggat    960

ttcattcatc attaagagac cttttttaga gccaaagaag catgtaggtg gtcgtgtgat   1020

ggtaacagat gctgacaggt caatactatc tccaggtgga agttgtggcc ccatcaaagt   1080

gaaaactgaa cccacagaag attctggcat ttccctggaa atggcagctg tgacagtaaa   1140

ggaagaatca gaagatcctg attattatca atataacatt caaggaagcc accattcttc   1200

agagggcaat gaaggcacag aaatggaagt accagcagaa gattctactc aacatgtccc   1260

ttcagaaaca agtgaggacc ctgaagttga ggtgactatt gaagatgatg attattctcc   1320

accgtctaag agaccaaagg ccaatgagct accgcagcca ccagtcccgg aacccgccaa   1380

tgctgggaag cggaaagtga gggagttcaa cttcgagaaa tggaatgctc gcatcactga   1440

tctacgtaaa caagttgaag aattgtttga aaggaaatat gctcaagcca taaaagccaa   1500

aggtccggtg acgatcccgt accctctttt ccagtctcat gttgaagatc tttatgtaga   1560

aggacttcct gaaggaattc cttttagaag gccatctact tacggaattc ctcgcctgga   1620

gaggatatta cttgcaaagg aaaggattcg ttttgtgatt aagaaacatg agcttctgaa   1680

ttcaacacgt gaagatttac agcttgataa gccagcttca ggagtaaagg aagaatggta   1740

tgccagaatc actaaattaa gaaagatggt ggatcagctt ttctgcaaaa aatttgcgga   1800

agccttgggg agcactgaag ccaaggctgt accgtaccaa aaatttgagg cacacccgaa   1860

tgatctgtac gtggaaggac tgccagaaaa cattcctttc cgaagtccct catggtatgg   1920

aatcccaagg ctggaaaaaa tcattcaagt gggcaatcga attaaatttg ttattaaaag   1980

accagaactt ctgactcaca gtaccactga agttactcag ccaagaacga atacaccagt   2040

caaagaagat tggaatgtca gaattaccaa gctacggaag caagtggaag agatttttaa   2100

tttgaaattt gcttagattt gttgacagcg gtttcctgga gtgctgtctt gagaacgatt   2160

ctgaggaggc tcagcaagaa agagtgtttc agttgattgg gtgtgtctgt catggagaag   2220

gaactcaagc tcttggactc accgaggcag taaaagtacc atatcctgtg tttgaatcaa   2280

acccggagtt cttgtatgtg gaaggcttgc cagaggggat tcccttccga agccctacct   2340

ggtttggaat tccacgactt gaaaggatcg tccgcgggag taataaaatc aagttcgttg   2400

ttaaaaaacc tgaactagtt atttcctact tgcctcctgg gatggctagt aaaataaaca   2460

ctaaagcttt gcagtccccc aaaagaccac gaagtcctgg gagtaattca aaggttcctg   2520

aaattgaggt caccgtggaa ggccctaata acaacaatcc tcaaacctca gctgttcgaa   2580

ccccgaccca gactaacggt tctaacgttc ccttcaagcc acgagggaga gagttttcct   2640

ttgaggcctg gaatgccaaa atcacggacc taaaacagaa agttgaaaat ctcttcaatg   2700

agaaatgtgg ggaagctctt ggccttaaac aagctgtgaa ggtgccgttc gcgttatttg   2760

agtctttccc ggaagacttt tatgtggaag gcttacctga gggtgtgcca ttccgaagac   2820

catcgacttt tggcattccg aggctggaga agatactcag aaacaaagcc aaaattaagt   2880

tcatcattaa aaagcccgaa atgtttgaga cggcgattaa ggagagcacc tcctctaaga   2940

gccctcccag aaaaataaat tcatcaccca atgttaatac tactgcatca ggtgttgaag   3000

accttaacat cattcaggtg acaattccag atgatgataa tgaaagactc tcgaaagttg   3060

aaaaagctag acagctaaga gaacaagtga atgacctctt tagtcggaaa tttggtgaag   3120

ctattggtat gggttttcct gtgaaagttc cctacaggaa aatcacaatt aaccctggct   3180

gtgtggtggt tgatggcatg cccccggggg tgtccttcaa agcccccagc tacctggaaa   3240

tcagctccat gagaaggatc ttagactctg ccgagtttat caaattcacg gtcattagac   3300

catttccagg acttgtgatt aataaccagc tggttgatca gagtgagtca gaaggccccg   3360

tgatacaaga atcagctgaa ccaagccagt tggaagttcc agccacagaa gaaataaaag   3420

agactgatgg aagctctcag atcaagcaag aaccagaccc cacgtggtag acctcttccc   3480

tcctaggcaa aaccatctgg atcacctaac agtcagaggt cagtatctca gcgtgtgaat   3540

tatagaggaa atacagagag aacctcttcc acttttactt ttcgtccaaa taaaatgcat   3600

ggtgtaccag aagttgaaga tcgggttgag gattggggct agctcgatga cactaaggcc   3660

ccaacatcgc gggacctgct gtggcgcgga ttcttaggaa cgctgttcta gccggccccc   3720

tctccagggg tcgccgtggc cggcattatt tcctagttct tcttgtaacc ctgaggtgcc   3780

agcgcgggga gtgaggaggg gtcagggggc taaggatgca acctctgacg ttctgcgcct   3840

tcctaggaga gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt aaaataccag   3900

ctctacaaga agctaggctc tgtgacggca tagttttcag tagctttatc acaatattca   3960

caatggagaa ttatatgaca tggtagcaga aataggccct tttatgtgtt gcttctattt   4020

tacctcaaat tgtagatata gggtaatcaa taaaatccat ccatgccttt cacacactaa   4080

gt                                                                  4082


<210>  4975
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  4975

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala 



<210>  4976
<211>  7291
<212>  DNA
<213>  Homo sapiens

<400>  4976
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   2040

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2100

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2160

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2220

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2280

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2340

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2400

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2460

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2520

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2580

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2640

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2700

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2760

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2820

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2880

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   2940

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   3000

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3060

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3120

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3180

ttcacggtca ttaggtaagt gagagtttcc tgcttagtca caggagcgaa tctggagctc   3240

atgaggctga ctcttctaaa atgcagccac aggtagtcat cgaatccggc ttcctatgct   3300

gtgcaatcaa caaatcaaaa taacttgtgt catcattaga atgtcagatg tgcttctacg   3360

aactaagctg actcttttaa ttctttggca aagggttggc aaactaggac tgtttgccaa   3420

attcaggctg cctcctattt ttagagtctt cctgaaacac agctacaccc gtattatcca   3480

tggctgcttt cctgtcacag tgagtaagta gctgggactg agaaggcatg gcctccaaag   3540

tctaaaatat ttactctcta gcactttgta gaaaaacctt agctaggcac agtggctaac   3600

gcctgtaatc ccagcatttt gggaggccaa ggcaggcaga tcacctgagg tcaggagttc   3660

cagaccagcc tggccaacat ggtgaaatcc catctctaca aaaataaaac agttagctgg   3720

gcatgatggc gggtgcctgt aatcccagct actcgggagg ctgaggcagg atagtcgctt   3780

gaacccagga ggtggaggtt gcaatgagcc aagatcatgc cactgcactc cagcctggac   3840

gacagagtga gactccatca caagaaaaaa agaactttgt caacctctgt cttagggcgc   3900

cttgtcacag gcttcgggtc agacggattc aaccttgcat cagccatttg ttagccaggt   3960

cactctgttc tttgtctgta aatgagattg atcgttgttc ccactgagag tgtcagctcc   4020

ttcccgtaga gcaggcatga tgattgtact cacctctgac accattgtga gtgccacatt   4080

ccttcccacg tccttgtcac tgtaagagat gcccacctga gcaccaaccc caggttatct   4140

tcccctttgt cttccagccc cccagaaaca gctacgactc aacctaccca atcatttcat   4200

catcagattg ccactgtctc tagttcaggt ctcttgggac tggcactcag aaatctcata   4260

ataaatcctc ttgaggcttc tcatacactc gtcttcttcc aatcttcttt ccctcaaaat   4320

ctcatatttt ggttccactt cacccaccgt cattctccat atcactccca ggagttaggc   4380

aaaaagcccc ttccgttctt ccgtatgtta aacttagaat cactctgttc cctgctctgc   4440

gtttctattt tttgtttttc ctccatttac tagtagctta acactttcta acagtgttct   4500

tattattgat acgtatctat ctcttccata agcttataag gtcacggata atacttctca   4560

ttgtagtacg taaatgacgt gggctagata tgagttgaat aaacagttat acctgtaaat   4620

tcttacagag tgaaaataaa ttgttatact ttacaatttg tttctctctt tagaccattt   4680

ccaggacttg tgattaataa ccgtgagtat tttgtgaagt gttttgtttt tgttttttcc   4740

tggggtctga cgtgtgtgcg tgtgagtgtg tatacatgct taacgtatat cacgttactt   4800

cacctatgtc agtaaccagg ccaaatactt gttttagccc tcagtaaaaa caccaggcac   4860

ttcctagttg taaaattatt caagcttctt aacttcctat cctcgatgca cttaatcata   4920

aaatggtaat aatagcaccg attttggggg agtcgttcca gtagatggaa agcatctgga   4980

acaggtgtca gcaagctcct gccgacgtgt atgcataaag ttttattgaa accaccatcg   5040

tgtccatttg tttatggcag aactgagaga tggcagcagc aagtgtgtgc ctgcaaaacc   5100

taaaatattt actaattggc tctgcaagaa aagagtttgc atccccctaa cctagaacag   5160

tgtctagcct ctagtatgtg tttagcctac agtatgtgct cagcgaatac aatctatatt   5220

tattactgct tttatgactg ttataattac tgtgcttgga tttcgttaca aagtaagtca   5280

caatgtgcct gcttctgtta gtatttcagc acagtgcctg gcacacatgg ggctctcaaa   5340

tattgctgag cgagtgaaca aatgtccttt caattcctta acgttgatgt cattttcaat   5400

agtattttga gccaaactta attttgcgag tgtgttttgt tttcttaact ttattattaa   5460

aaatgtataa aagtgaggcc aggcgtggtg gctcacgcct gtaatcccag cagtttggga   5520

ggctgaggca ggcggatcag ttgaggttgg gagttggaga ccagcccgtc caacatggtg   5580

aaagcctgtc tctactaaaa atacaaaaat cagctgggtg tggtggcgcg tgcctgtaat   5640

cccagctact caggaggctg aggcaggaga gttgcttgaa tcctagaggt ggaggttgca   5700

gtgagctgag atcgtgccat tgcactccag cctgggcaac aagagcaaaa ctctgtccca   5760

ataaataaat aaataaaatg ttctcttttg ttcctgttct tgtgcggtag tgtggtatag   5820

agttttatgg taattactgt gaattagtga ttctgaggga catatcagaa ctctgaggtt   5880

tgtttccttc tcatcttgag ggaaacagca aatgtatgtt aaaatgcttt tccaagggaa   5940

caacacatcc ttacattatt taaaccaatc tgcttcattt tcagagctgg ttgatcagag   6000

tgagtcagaa ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc   6060

cacagaagaa ataaaagaga ctgatggaag ctctcagatc aagcaagaac cagaccccac   6120

gtggtagacc tcttccctcc taggcttaaa gtatcagtgg ttgagaagag cttttcggac   6180

ctgttactac cccaagctgt gtaatatact tgtataacag aaataccttc tatacaaacc   6240

tttttttcta cttttagata gaaatgtcta ctttttcagc agttctgtga attaaagagc   6300

agagtgactg tgggtctgga atggctggtg tacttgggaa tgtactatca ggattttaca   6360

gcaatgctgg gaaatgacag ggaaaatgac aggaatgaat ctcaccagat tttttatgta   6420

ctcagcagag ccttgagtta cggtgtttat tttccaatca agtgaagata tctcctactt   6480

ctcctactgg aacatctcag cttctgcagt gaagaaaaat tcctgtgata gttcagttct   6540

ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat cctttgttca cggctctcct   6600

taatgactga gtgaacagtt cctatctgta tatttgacta aaccttttcc taagctatct   6660

ctcatggttc ctatgttttt ttatcataat taaaagcaaa accatctgga tcacctaaca   6720

gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa tacagagaga acctcttcca   6780

cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga agttgaagat cgggttgagg   6840

attggggcta gctcgatgac actaaggccc caacatcgcg ggacctgctg tggcgcggat   6900

tcttaggaac gctgttctag ccggccccct ctccaggggt cgccgtggcc ggcattattt   6960

cctagttctt cttgtaaccc tgaggtgcca gcgcggggag tgaggagggg tcagggggct   7020

aaggatgcaa cctctgacgt tctgcgcctt cctaggagag tcttacatgt gttgagattt   7080

cacaagcaat gcgagttgta aaataccagc tctacaagaa gctaggctct gtgacggcat   7140

agttttcagt agctttatca caatattcac aatggagaat tatatgacat ggtagcagaa   7200

ataggccctt ttatgtgttg cttctatttt acctcaaatt gtagatatag ggtaatcaat   7260

aaaatccatc catgcctttc acacactaag t                                  7291


<210>  4977
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  4977

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala 
            580


<210>  4978
<211>  4992
<212>  DNA
<213>  Homo sapiens

<400>  4978
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040

taccatatcc tgtgtttgaa tcaaacccgg agttcttgaa aggatcgtcc gcgggagtaa   2100

taaaatcaag ttcgttgtta aaaaacctga actagttatt tcctacttgc ctcctgggat   2160

ggctagtaaa ataaacacta aagctttgca gtcccccaaa agaccacgaa gtcctgggag   2220

taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc cctaataaca acaatcctca   2280

aacctcagct gttcgaaccc cgacccagac taacggttct aacgttccct tcaagccacg   2340

agggagagag ttttcctttg aggcctggaa tgccaaaatc acggacctaa aacagaaagt   2400

tgaaaatctc ttcaatgaga aatgtgggga agctcttggc cttaaacaag ctgtgaaggt   2460

gccgttcgcg ttatttgagt ctttcccgga agacttttat gtggaaggct tacctgaggg   2520

tgtgccattc cgaagaccat cgacttttgg cattccgagg ctggagaaga tactcagaaa   2580

caaagccaaa attaagttca tcattaaaaa gcccgaaatg tttgagacgg cgattaagga   2640

gagcacctcc tctaagagcc ctcccagaaa aataaattca tcacccaatg ttaatactac   2700

tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca attccagatg atgataatga   2760

aagactctcg aaagttgaaa aagctagaca gctaagagaa caagtgaatg acctctttag   2820

tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg aaagttccct acaggaaaat   2880

cacaattaac cctggctgtg tggtggttga tggcatgccc ccgggggtgt ccttcaaagc   2940

ccccagctac ctggaaatca gctccatgag aaggatctta gactctgccg agtttatcaa   3000

attcacggtc attagaccat ttccaggact tgtgattaat aaccagctgg ttgatcagag   3060

tgagtcagaa ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc   3120

cacagaaggt aaaaggacct cttccctcct agggtaaatc agcttctgtg tcagggatgc   3180

tgtgtggtgt ccatctgaac cccctgcata cgcgtagcta atgtgatctc cccactttca   3240

cataagatgg tggccctgcc ttcagggaat gtgggagcca ggtgggagcc ttcccggata   3300

tttaagctag aagattctac agggagattc tccttggatc aatatatgtc tctcagtcaa   3360

agatgtaaaa gcacttttgc cttaaaaaga atgttctgtt tctaaataga gtcaacgttg   3420

tcctcctcat tggaattcac tatgagtcag aatcattaga ctgacttttt tttttccata   3480

gtaatagtat tttgcagagt ctcacagagc tgcagatctt ttgttcatct tgcagagtta   3540

acaagtctga tcctgttagt ccagatttct taaatttggc caagttataa taggagcagt   3600

agcttgagac ccgaagtcag gaaactttga caatggattt ttttttttaa tccagagact   3660

tgtactggaa tttgccttac cctgtcagct catggactta aggtttcatc ccgctttatg   3720

agtgcttctg aatccaagtc attgttacct gaatttgcaa attaagttgt gatattcgtg   3780

actgttaaat tcctgtaatt agattaacct ctttgcttgc ttgtttgttt tctctcctat   3840

tttagcttaa agtatcagtg gttgagaaga gcttttcgga cctgttacta ccccaagctg   3900

tgtaatatac ttgtataaca gaaatacctt ctatacaaac ctttttttct acttttagat   3960

agaaatgtct actttttcag cagttctgtg aattaaagag cagagtgact gtgggtctgg   4020

aatggctggt gtacttggga atgtactatc aggattttac agcaatgctg ggaaatgaca   4080

gggaaaatga caggaatgaa tctcaccaga ttttttatgt actcagcaga gccttgagtt   4140

acggtgttta ttttccaatc aagtgaagat atctcctact tctcctactg gaacatctca   4200

gcttctgcag tgaagaaaaa ttcctgtgat agttcagttc tttagttttt ctatttgaaa   4260

aaaaaaaatc atttaaatga tcctttgttc acggctctcc ttaatgactg agtgaacagt   4320

tcctatctgt atatttgact aaaccttttc ctaagctatc tctcatggtt cctatgtttt   4380

tttatcataa ttaaaagcaa aaccatctgg atcacctaac agtcagaggt cagtatctca   4440

gcgtgtgaat tatagaggaa atacagagag aacctcttcc acttttactt ttcgtccaaa   4500

taaaatgcat ggtgtaccag aagttgaaga tcgggttgag gattggggct agctcgatga   4560

cactaaggcc ccaacatcgc gggacctgct gtggcgcgga ttcttaggaa cgctgttcta   4620

gccggccccc tctccagggg tcgccgtggc cggcattatt tcctagttct tcttgtaacc   4680

ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc taaggatgca acctctgacg   4740

ttctgcgcct tcctaggaga gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt   4800

aaaataccag ctctacaaga agctaggctc tgtgacggca tagttttcag tagctttatc   4860

acaatattca caatggagaa ttatatgaca tggtagcaga aataggccct tttatgtgtt   4920

gcttctattt tacctcaaat tgtagatata gggtaatcaa taaaatccat ccatgccttt   4980

cacacactaa gt                                                       4992


<210>  4979
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  4979

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys 
        595                 600                 605


Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu 
    610                 615                 620


Asn 
625


<210>  4980
<211>  4286
<212>  DNA
<213>  Homo sapiens

<400>  4980
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1080

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1140

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1200

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1260

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1320

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1380

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1440

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1500

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1560

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1620

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1680

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1740

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1800

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1860

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   1920

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   1980

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2040

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2100

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2160

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2220

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2280

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2340

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2400

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2460

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2520

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2580

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2640

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2700

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2760

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2820

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   2880

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   2940

cggtcattag accatttcca ggacttgtga ttaataacca gctggttgat cagagtgagt   3000

cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt ccagccacag   3060

aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac cccacgtggt   3120

agacctcttc cctcctaggc ttaaagtatc agtggttgag aagagctttt cggacctgtt   3180

actaccccaa gctgtgtaat atacttgtat aacagaaata ccttctatac aaaccttttt   3240

ttctactttt agatagaaat gtctactttt tcagcagttc tgtgaattaa agagcagagt   3300

gactgtgggt ctggaatggc tggtgtactt gggaatgtac tatcaggatt ttacagcaat   3360

gctgggaaat gacagggaaa atgacaggaa tgaatctcac cagatttttt atgtactcag   3420

cagagccttg agttacggtg tttattttcc aatcaagtga agatatctcc tacttctcct   3480

actggaacat ctcagcttct gcagtgaaga aaaattcctg tgatagttca gttctttagt   3540

ttttctattt gaaaaaaaaa aatcatttaa atgatccttt gttcacggct ctccttaatg   3600

actgagtgaa cagttcctat ctgtatattt gactaaacct tttcctaagc tatctctcat   3660

ggttcctatg tttttttatc ataattaaaa gcaaaaccat ctggatcacc taacagtcag   3720

aggtcagtat ctcagcgtgt gaattataga ggaaatacag agagaacctc ttccactttt   3780

acttttcgtc caaataaaat gcatggtgta ccagaagttg aagatcgggt tgaggattgg   3840

ggctagctcg atgacactaa ggccccaaca tcgcgggacc tgctgtggcg cggattctta   3900

ggaacgctgt tctagccggc cccctctcca ggggtcgccg tggccggcat tatttcctag   3960

ttcttcttgt aaccctgagg tgccagcgcg gggagtgagg aggggtcagg gggctaagga   4020

tgcaacctct gacgttctgc gccttcctag gagagtctta catgtgttga gatttcacaa   4080

gcaatgcgag ttgtaaaata ccagctctac aagaagctag gctctgtgac ggcatagttt   4140

tcagtagctt tatcacaata ttcacaatgg agaattatat gacatggtag cagaaatagg   4200

cccttttatg tgttgcttct attttacctc aaattgtaga tatagggtaa tcaataaaat   4260

ccatccatgc ctttcacaca ctaagt                                        4286


<210>  4981
<211>  954
<212>  PRT
<213>  Homo sapiens

<400>  4981

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly 
    530                 535                 540


Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro 
545                 550                 555                 560


Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser 
                565                 570                 575


Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser 
            580                 585                 590


Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr 
        595                 600                 605


Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser 
    610                 615                 620


Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile 
625                 630                 635                 640


Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala 
                645                 650                 655


Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro 
            660                 665                 670


Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp 
        675                 680                 685


Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala 
    690                 695                 700


Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser 
705                 710                 715                 720


Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe 
                725                 730                 735


Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg 
            740                 745                 750


Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu 
        755                 760                 765


Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile 
    770                 775                 780


Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu 
785                 790                 795                 800


Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser 
                805                 810                 815


Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe 
            820                 825                 830


Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val 
        835                 840                 845


Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly 
    850                 855                 860


Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser 
865                 870                 875                 880


Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val 
                885                 890                 895


Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln 
            900                 905                 910


Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln 
        915                 920                 925


Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser 
    930                 935                 940


Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  4982
<211>  4004
<212>  DNA
<213>  Homo sapiens

<400>  4982
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1980

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   2040

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2100

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2160

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2220

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2280

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2340

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2400

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2460

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2520

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2580

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2640

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2700

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2760

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2820

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2880

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   2940

cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg atcagagtga   3000

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   3060

agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag accccacgtg   3120

gtagacctct tccctcctag gagccttgag ttacggtgtt tattttccaa tcaagtgaag   3180

atatctccta cttctcctac tggaacatct cagcttctgc agtgaagaaa aattcctgtg   3240

atagttcagt tctttagttt ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt   3300

tcacggctct ccttaatgac tgagtgaaca gttcctatct gtatatttga ctaaaccttt   3360

tcctaagcta tctctcatgg ttcctatgtt tttttatcat aattaaaagc aaaaccatct   3420

ggatcaccta acagtcagag gtcagtatct cagcgtgtga attatagagg aaatacagag   3480

agaacctctt ccacttttac ttttcgtcca aataaaatgc atggtgtacc agaagttgaa   3540

gatcgggttg aggattgggg ctagctcgat gacactaagg ccccaacatc gcgggacctg   3600

ctgtggcgcg gattcttagg aacgctgttc tagccggccc cctctccagg ggtcgccgtg   3660

gccggcatta tttcctagtt cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag   3720

gggtcagggg gctaaggatg caacctctga cgttctgcgc cttcctagga gagtcttaca   3780

tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc agctctacaa gaagctaggc   3840

tctgtgacgg catagttttc agtagcttta tcacaatatt cacaatggag aattatatga   3900

catggtagca gaaataggcc cttttatgtg ttgcttctat tttacctcaa attgtagata   3960

tagggtaatc aataaaatcc atccatgcct ttcacacact aagt                    4004


<210>  4983
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  4983

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
                565                 570                 575


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly 
            580                 585                 590


Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600


<210>  4984
<211>  7661
<212>  DNA
<213>  Homo sapiens

<400>  4984
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag    960

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1020

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1080

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1140

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1200

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1260

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1320

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1380

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1440

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1500

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1560

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1620

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1680

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1740

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagctc   1800

aagctcttgg actcaccgag gcagtaaaag taccatatcc tgtgtttgaa tcaaacccgg   1860

agttcttgta tgtggaaggc ttgccagagg ggattccctt ccgaagccct acctggtttg   1920

gaattccacg acttgaaagg atcgtccgcg ggagtaataa aatcaagttc gttgttaaaa   1980

aacctgaact agttatttcc tacttgcctc ctgggatggc tagtaaaata aacactaaag   2040

ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa ttcaaaggtt cctgaaattg   2100

aggtcaccgt ggaaggccct aataacaaca atcctcaaac ctcagctgtt cgaaccccga   2160

cccagactaa cggttctaac gttcccttca agccacgagg gagagagttt tcctttgagg   2220

cctggaatgc caaaatcacg gacctaaaac agaaagttga aaatctcttc aatgagaaat   2280

gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc gttcgcgtta tttgagtctt   2340

tcccggaaga cttttatgtg gaaggcttac ctgagggtgt gccattccga agaccatcga   2400

cttttggcat tccgaggctg gagaagatac tcagaaacaa agccaaaatt aagttcatca   2460

ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag cacctcctct aagagccctc   2520

ccagaaaaat aaattcatca cccaatgtta atactactgc atcaggtgtt gaagacctta   2580

acatcattca ggtgacaatt ccagatgatg ataatgaaag actctcgaaa gttgaaaaag   2640

ctagacagct aagagaacaa gtgaatgacc tctttagtcg gaaatttggt gaagctattg   2700

gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac aattaaccct ggctgtgtgg   2760

tggttgatgg catgcccccg ggggtgtcct tcaaagcccc cagctacctg gaaatcagct   2820

ccatgagaag gatcttagac tctgccgagt ttatcaaatt cacggtcatt aggtaagtga   2880

gagtttcctg cttagtcaca ggagcgaatc tggagctcat gaggctgact cttctaaaat   2940

gcagccacag gtagtcatcg aatccggctt cctatgctgt gcaatcaaca aatcaaaata   3000

acttgtgtca tcattagaat gtcagatgtg cttctacgaa ctaagctgac tcttttaatt   3060

ctttggcaaa gggttggcaa actaggactg tttgccaaat tcaggctgcc tcctattttt   3120

agagtcttcc tgaaacacag ctacacccgt attatccatg gctgctttcc tgtcacagtg   3180

agtaagtagc tgggactgag aaggcatggc ctccaaagtc taaaatattt actctctagc   3240

actttgtaga aaaaccttag ctaggcacag tggctaacgc ctgtaatccc agcattttgg   3300

gaggccaagg caggcagatc acctgaggtc aggagttcca gaccagcctg gccaacatgg   3360

tgaaatccca tctctacaaa aataaaacag ttagctgggc atgatggcgg gtgcctgtaa   3420

tcccagctac tcgggaggct gaggcaggat agtcgcttga acccaggagg tggaggttgc   3480

aatgagccaa gatcatgcca ctgcactcca gcctggacga cagagtgaga ctccatcaca   3540

agaaaaaaag aactttgtca acctctgtct tagggcgcct tgtcacaggc ttcgggtcag   3600

acggattcaa ccttgcatca gccatttgtt agccaggtca ctctgttctt tgtctgtaaa   3660

tgagattgat cgttgttccc actgagagtg tcagctcctt cccgtagagc aggcatgatg   3720

attgtactca cctctgacac cattgtgagt gccacattcc ttcccacgtc cttgtcactg   3780

taagagatgc ccacctgagc accaacccca ggttatcttc ccctttgtct tccagccccc   3840

cagaaacagc tacgactcaa cctacccaat catttcatca tcagattgcc actgtctcta   3900

gttcaggtct cttgggactg gcactcagaa atctcataat aaatcctctt gaggcttctc   3960

atacactcgt cttcttccaa tcttctttcc ctcaaaatct catattttgg ttccacttca   4020

cccaccgtca ttctccatat cactcccagg agttaggcaa aaagcccctt ccgttcttcc   4080

gtatgttaaa cttagaatca ctctgttccc tgctctgcgt ttctattttt tgtttttcct   4140

ccatttacta gtagcttaac actttctaac agtgttctta ttattgatac gtatctatct   4200

cttccataag cttataaggt cacggataat acttctcatt gtagtacgta aatgacgtgg   4260

gctagatatg agttgaataa acagttatac ctgtaaattc ttacagagtg aaaataaatt   4320

gttatacttt acaatttgtt tctctcttta gaccatttcc aggacttgtg attaataacc   4380

gtgagtattt tgtgaagtgt tttgtttttg ttttttcctg gggtctgacg tgtgtgcgtg   4440

tgagtgtgta tacatgctta acgtatatca cgttacttca cctatgtcag taaccaggcc   4500

aaatacttgt tttagccctc agtaaaaaca ccaggcactt cctagttgta aaattattca   4560

agcttcttaa cttcctatcc tcgatgcact taatcataaa atggtaataa tagcaccgat   4620

tttgggggag tcgttccagt agatggaaag catctggaac aggtgtcagc aagctcctgc   4680

cgacgtgtat gcataaagtt ttattgaaac caccatcgtg tccatttgtt tatggcagaa   4740

ctgagagatg gcagcagcaa gtgtgtgcct gcaaaaccta aaatatttac taattggctc   4800

tgcaagaaaa gagtttgcat ccccctaacc tagaacagtg tctagcctct agtatgtgtt   4860

tagcctacag tatgtgctca gcgaatacaa tctatattta ttactgcttt tatgactgtt   4920

ataattactg tgcttggatt tcgttacaaa gtaagtcaca atgtgcctgc ttctgttagt   4980

atttcagcac agtgcctggc acacatgggg ctctcaaata ttgctgagcg agtgaacaaa   5040

tgtcctttca attccttaac gttgatgtca ttttcaatag tattttgagc caaacttaat   5100

tttgcgagtg tgttttgttt tcttaacttt attattaaaa atgtataaaa gtgaggccag   5160

gcgtggtggc tcacgcctgt aatcccagca gtttgggagg ctgaggcagg cggatcagtt   5220

gaggttggga gttggagacc agcccgtcca acatggtgaa agcctgtctc tactaaaaat   5280

acaaaaatca gctgggtgtg gtggcgcgtg cctgtaatcc cagctactca ggaggctgag   5340

gcaggagagt tgcttgaatc ctagaggtgg aggttgcagt gagctgagat cgtgccattg   5400

cactccagcc tgggcaacaa gagcaaaact ctgtcccaat aaataaataa ataaaatgtt   5460

ctcttttgtt cctgttcttg tgcggtagtg tggtatagag ttttatggta attactgtga   5520

attagtgatt ctgagggaca tatcagaact ctgaggtttg tttccttctc atcttgaggg   5580

aaacagcaaa tgtatgttaa aatgcttttc caagggaaca acacatcctt acattattta   5640

aaccaatctg cttcattttc agagctggtt gatcagagtg agtcagaagg ccccgtgata   5700

caagaatcag ctgaaccaag ccagttggaa gttccagcca cagaagaaat aaaagagact   5760

gatggaagct ctcagatcaa gcaagaacca gaccccacgt ggtagacctc ttccctccta   5820

gggtaaatca gcttctgtgt cagggatgct gtgtggtgtc catctgaacc ccctgcatac   5880

gcgtagctaa tgtgatctcc ccactttcac ataagatggt ggccctgcct tcagggaatg   5940

tgggagccag gtgggagcct tcccggatat ttaagctaga agattctaca gggagattct   6000

ccttggatca atatatgtct ctcagtcaaa gatgtaaaag cacttttgcc ttaaaaagaa   6060

tgttctgttt ctaaatagag tcaacgttgt cctcctcatt ggaattcact atgagtcaga   6120

atcattagac tgactttttt ttttccatag taatagtatt ttgcagagtc tcacagagct   6180

gcagatcttt tgttcatctt gcagagttaa caagtctgat cctgttagtc cagatttctt   6240

aaatttggcc aagttataat aggagcagta gcttgagacc cgaagtcagg aaactttgac   6300

aatggatttt tttttttaat ccagagactt gtactggaat ttgccttacc ctgtcagctc   6360

atggacttaa ggtttcatcc cgctttatga gtgcttctga atccaagtca ttgttacctg   6420

aatttgcaaa ttaagttgtg atattcgtga ctgttaaatt cctgtaatta gattaacctc   6480

tttgcttgct tgtttgtttt ctctcctatt ttagcttaaa gtatcagtgg ttgagaagag   6540

cttttcggac ctgttactac cccaagctgt gtaatatact tgtataacag aaataccttc   6600

tatacaaacc tttttttcta cttttagata gaaatgtcta ctttttcagc agttctgtga   6660

attaaagagc agagtgactg tgggtctgga atggctggtg tacttgggaa tgtactatca   6720

ggattttaca gcaatgctgg gaaatgacag ggaaaatgac aggaatgaat ctcaccagat   6780

tttttatgta ctcagcagag ccttgagtta cggtgtttat tttccaatca agtgaagata   6840

tctcctactt ctcctactgg aacatctcag cttctgcagt gaagaaaaat tcctgtgata   6900

gttcagttct ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat cctttgttca   6960

cggctctcct taatgactga gtgaacagtt cctatctgta tatttgacta aaccttttcc   7020

taagctatct ctcatggttc ctatgttttt ttatcataat taaaagcaaa accatctgga   7080

tcacctaaca gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa tacagagaga   7140

acctcttcca cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga agttgaagat   7200

cgggttgagg attggggcta gctcgatgac actaaggccc caacatcgcg ggacctgctg   7260

tggcgcggat tcttaggaac gctgttctag ccggccccct ctccaggggt cgccgtggcc   7320

ggcattattt cctagttctt cttgtaaccc tgaggtgcca gcgcggggag tgaggagggg   7380

tcagggggct aaggatgcaa cctctgacgt tctgcgcctt cctaggagag tcttacatgt   7440

gttgagattt cacaagcaat gcgagttgta aaataccagc tctacaagaa gctaggctct   7500

gtgacggcat agttttcagt agctttatca caatattcac aatggagaat tatatgacat   7560

ggtagcagaa ataggccctt ttatgtgttg cttctatttt acctcaaatt gtagatatag   7620

ggtaatcaat aaaatccatc catgcctttc acacactaag t                       7661


<210>  4985
<211>  872
<212>  PRT
<213>  Homo sapiens

<400>  4985

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro 
        515                 520                 525


Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu 
    530                 535                 540


Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu 
545                 550                 555                 560


Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro 
                565                 570                 575


Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn 
            580                 585                 590


Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn 
        595                 600                 605


Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn 
    610                 615                 620


Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser 
625                 630                 635                 640


Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp 
                645                 650                 655


Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn 
            660                 665                 670


Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro 
        675                 680                 685


Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu 
    690                 695                 700


Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg 
705                 710                 715                 720


Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys 
                725                 730                 735


Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys 
            740                 745                 750


Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala 
        755                 760                 765


Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp 
    770                 775                 780


Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu 
785                 790                 795                 800


Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met 
                805                 810                 815


Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly 
            820                 825                 830


Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro 
        835                 840                 845


Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu 
    850                 855                 860


Phe Ile Lys Phe Thr Val Ile Arg 
865                 870


<210>  4986
<211>  4055
<212>  DNA
<213>  Homo sapiens

<400>  4986
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agctcaagct cttggactca ccgaggcagt aaaagtacca tatcctgtgt   1920

ttgaatcaaa cccggagttc ttgtatgtgg aaggcttgcc agaggggatt cccttccgaa   1980

gccctacctg gtttggaatt ccacgacttg aaaggatcgt ccgcgggagt aataaaatca   2040

agttcgttgt taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta   2100

aaataaacac taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa   2160

aggttcctga aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag   2220

ctgttcgaac cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag   2280

agttttcctt tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc   2340

tcttcaatga gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg   2400

cgttatttga gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat   2460

tccgaagacc atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca   2520

aaattaagtt catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct   2580

cctctaagag ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag   2640

gtgttgaaga ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct   2700

cgaaagttga aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat   2760

ttggtgaagc tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta   2820

accctggctg tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct   2880

acctggaaat cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg   2940

tcattagacc atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag   3000

aaggccccgt gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag   3060

aaataaaaga gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga   3120

cctcttccct cctaggctta aagtatcagt ggttgagaag agcttttcgg acctgttact   3180

accccaagct gtagccttga gttacggtgt ttattttcca atcaagtgaa gatatctcct   3240

acttctccta ctggaacatc tcagcttctg cagtgaagaa aaattcctgt gatagttcag   3300

ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa tgatcctttg ttcacggctc   3360

tccttaatga ctgagtgaac agttcctatc tgtatatttg actaaacctt ttcctaagct   3420

atctctcatg gttcctatgt ttttttatca taattaaaag caaaaccatc tggatcacct   3480

aacagtcaga ggtcagtatc tcagcgtgtg aattatagag gaaatacaga gagaacctct   3540

tccactttta cttttcgtcc aaataaaatg catggtgtac cagaagttga agatcgggtt   3600

gaggattggg gctagctcga tgacactaag gccccaacat cgcgggacct gctgtggcgc   3660

ggattcttag gaacgctgtt ctagccggcc ccctctccag gggtcgccgt ggccggcatt   3720

atttcctagt tcttcttgta accctgaggt gccagcgcgg ggagtgagga ggggtcaggg   3780

ggctaaggat gcaacctctg acgttctgcg ccttcctagg agagtcttac atgtgttgag   3840

atttcacaag caatgcgagt tgtaaaatac cagctctaca agaagctagg ctctgtgacg   3900

gcatagtttt cagtagcttt atcacaatat tcacaatgga gaattatatg acatggtagc   3960

agaaataggc ccttttatgt gttgcttcta ttttacctca aattgtagat atagggtaat   4020

caataaaatc catccatgcc tttcacacac taagt                              4055


<210>  4987
<211>  953
<212>  PRT
<213>  Homo sapiens

<400>  4987

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu 
    530                 535                 540


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
545                 550                 555                 560


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
                565                 570                 575


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
            580                 585                 590


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
        595                 600                 605


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
    610                 615                 620


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
625                 630                 635                 640


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
                645                 650                 655


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
            660                 665                 670


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
        675                 680                 685


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
    690                 695                 700


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
705                 710                 715                 720


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
                725                 730                 735


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
            740                 745                 750


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
        755                 760                 765


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
    770                 775                 780


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
785                 790                 795                 800


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
                805                 810                 815


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
            820                 825                 830


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
        835                 840                 845


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
    850                 855                 860


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
865                 870                 875                 880


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
                885                 890                 895


Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser 
            900                 905                 910


Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu 
        915                 920                 925


Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln 
    930                 935                 940


Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  4988
<211>  4288
<212>  DNA
<213>  Homo sapiens

<400>  4988
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1980

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   2040

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2100

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2160

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2220

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2280

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2340

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2400

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2460

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2520

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2580

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2640

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2700

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2760

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2820

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2880

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   2940

cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg atcagagtga   3000

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   3060

agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag accccacgtg   3120

gtagacctct tccctcctag gcttaaagta tcagtggttg agaagagctt ttcggacctg   3180

ttactacccc aagctgtgta atatacttgt ataacagaaa taccttctat acaaaccttt   3240

ttttctactt ttagatagaa atgtctactt tttcagcagt tctgtgaatt aaagagcaga   3300

gtgactgtgg gtctggaatg gctggtgtac ttgggaatgt actatcagga ttttacagca   3360

atgctgggaa atgacaggga aaatgacagg aatgaatctc accagatttt ttatgtactc   3420

agcagagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct cctacttctc   3480

ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta   3540

gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg ctctccttaa   3600

tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa gctatctctc   3660

atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca cctaacagtc   3720

agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc tcttccactt   3780

ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg gttgaggatt   3840

ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg cgcggattct   3900

taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc attatttcct   3960

agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca gggggctaag   4020

gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt gagatttcac   4080

aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg acggcatagt   4140

tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt agcagaaata   4200

ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt aatcaataaa   4260

atccatccat gcctttcaca cactaagt                                      4288


<210>  4989
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  4989

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
                565                 570                 575


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly 
            580                 585                 590


Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600


<210>  4990
<211>  7153
<212>  DNA
<213>  Homo sapiens

<400>  4990
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag    960

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1020

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1080

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1140

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1200

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1260

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1320

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1380

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1440

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1500

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1560

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1620

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1680

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1740

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1800

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1860

tgaaatttgc ttagatttgt tgacagcggt ttcctggagt gctgtcttga gaacgattct   1920

gaggaggctc agcaagaaag agtgtttcag ttgattgggt gtgtctgtca tggagaagga   1980

actcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac   2040

ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg   2100

tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2160

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2220

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2280

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2340

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2400

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2460

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2520

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2580

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2640

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2700

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2760

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2820

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2880

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   2940

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3000

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattaggtaa   3060

gtgagagttt cctgcttagt cacaggagcg aatctggagc tcatgaggct gactcttcta   3120

aaatgcagcc acaggtagtc atcgaatccg gcttcctatg ctgtgcaatc aacaaatcaa   3180

aataacttgt gtcatcatta gaatgtcaga tgtgcttcta cgaactaagc tgactctttt   3240

aattctttgg caaagggttg gcaaactagg actgtttgcc aaattcaggc tgcctcctat   3300

ttttagagtc ttcctgaaac acagctacac ccgtattatc catggctgct ttcctgtcac   3360

agtgagtaag tagctgggac tgagaaggca tggcctccaa agtctaaaat atttactctc   3420

tagcactttg tagaaaaacc ttagctaggc acagtggcta acgcctgtaa tcccagcatt   3480

ttgggaggcc aaggcaggca gatcacctga ggtcaggagt tccagaccag cctggccaac   3540

atggtgaaat cccatctcta caaaaataaa acagttagct gggcatgatg gcgggtgcct   3600

gtaatcccag ctactcggga ggctgaggca ggatagtcgc ttgaacccag gaggtggagg   3660

ttgcaatgag ccaagatcat gccactgcac tccagcctgg acgacagagt gagactccat   3720

cacaagaaaa aaagaacttt gtcaacctct gtcttagggc gccttgtcac aggcttcggg   3780

tcagacggat tcaaccttgc atcagccatt tgttagccag gtcactctgt tctttgtctg   3840

taaatgagat tgatcgttgt tcccactgag agtgtcagct ccttcccgta gagcaggcat   3900

gatgattgta ctcacctctg acaccattgt gagtgccaca ttccttccca cgtccttgtc   3960

actgtaagag atgcccacct gagcaccaac cccaggttat cttccccttt gtcttccagc   4020

cccccagaaa cagctacgac tcaacctacc caatcatttc atcatcagat tgccactgtc   4080

tctagttcag gtctcttggg actggcactc agaaatctca taataaatcc tcttgaggct   4140

tctcatacac tcgtcttctt ccaatcttct ttccctcaaa atctcatatt ttggttccac   4200

ttcacccacc gtcattctcc atatcactcc caggagttag gcaaaaagcc ccttccgttc   4260

ttccgtatgt taaacttaga atcactctgt tccctgctct gcgtttctat tttttgtttt   4320

tcctccattt actagtagct taacactttc taacagtgtt cttattattg atacgtatct   4380

atctcttcca taagcttata aggtcacgga taatacttct cattgtagta cgtaaatgac   4440

gtgggctaga tatgagttga ataaacagtt atacctgtaa attcttacag agtgaaaata   4500

aattgttata ctttacaatt tgtttctctc tttagaccat ttccaggact tgtgattaat   4560

aaccgtgagt attttgtgaa gtgttttgtt tttgtttttt cctggggtct gacgtgtgtg   4620

cgtgtgagtg tgtatacatg cttaacgtat atcacgttac ttcacctatg tcagtaacca   4680

ggccaaatac ttgttttagc cctcagtaaa aacaccaggc acttcctagt tgtaaaatta   4740

ttcaagcttc ttaacttcct atcctcgatg cacttaatca taaaatggta ataatagcac   4800

cgattttggg ggagtcgttc cagtagatgg aaagcatctg gaacaggtgt cagcaagctc   4860

ctgccgacgt gtatgcataa agttttattg aaaccaccat cgtgtccatt tgtttatggc   4920

agaactgaga gatggcagca gcaagtgtgt gcctgcaaaa cctaaaatat ttactaattg   4980

gctctgcaag aaaagagttt gcatccccct aacctagaac agtgtctagc ctctagtatg   5040

tgtttagcct acagtatgtg ctcagcgaat acaatctata tttattactg cttttatgac   5100

tgttataatt actgtgcttg gatttcgtta caaagtaagt cacaatgtgc ctgcttctgt   5160

tagtatttca gcacagtgcc tggcacacat ggggctctca aatattgctg agcgagtgaa   5220

caaatgtcct ttcaattcct taacgttgat gtcattttca atagtatttt gagccaaact   5280

taattttgcg agtgtgtttt gttttcttaa ctttattatt aaaaatgtat aaaagtgagg   5340

ccaggcgtgg tggctcacgc ctgtaatccc agcagtttgg gaggctgagg caggcggatc   5400

agttgaggtt gggagttgga gaccagcccg tccaacatgg tgaaagcctg tctctactaa   5460

aaatacaaaa atcagctggg tgtggtggcg cgtgcctgta atcccagcta ctcaggaggc   5520

tgaggcagga gagttgcttg aatcctagag gtggaggttg cagtgagctg agatcgtgcc   5580

attgcactcc agcctgggca acaagagcaa aactctgtcc caataaataa ataaataaaa   5640

tgttctcttt tgttcctgtt cttgtgcggt agtgtggtat agagttttat ggtaattact   5700

gtgaattagt gattctgagg gacatatcag aactctgagg tttgtttcct tctcatcttg   5760

agggaaacag caaatgtatg ttaaaatgct tttccaaggg aacaacacat ccttacatta   5820

tttaaaccaa tctgcttcat tttcagagct ggttgatcag agtgagtcag aaggccccgt   5880

gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag aaataaaaga   5940

gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga cctcttccct   6000

cctaggctta aagtatcagt ggttgagaag agcttttcgg acctgttact accccaagct   6060

gtgtaatata cttgtataac agaaatacct tctatacaaa cctttttttc tacttttaga   6120

tagaaatgtc tactttttca gcagttctgt gaattaaaga gcagagtgac tgtgggtctg   6180

gaatggctgg tgtacttggg aatgtactat caggatttta cagcaatgct gggaaatgac   6240

agggaaaatg acaggaatga atctcaccag attttttatg tactcagcag agccttgagt   6300

tacggtgttt attttccaat caagtgaaga tatctcctac ttctcctact ggaacatctc   6360

agcttctgca gtgaagaaaa attcctgtga tagttcagtt ctttagtttt tctatttgaa   6420

aaaaaaaaat catttaaatg atcctttgtt cacggctctc cttaatgact gagtgaacag   6480

ttcctatctg tatatttgac taaacctttt cctaagctat ctctcatggt tcctatgttt   6540

ttttatcata attaaaagca aaaccatctg gatcacctaa cagtcagagg tcagtatctc   6600

agcgtgtgaa ttatagagga aatacagaga gaacctcttc cacttttact tttcgtccaa   6660

ataaaatgca tggtgtacca gaagttgaag atcgggttga ggattggggc tagctcgatg   6720

acactaaggc cccaacatcg cgggacctgc tgtggcgcgg attcttagga acgctgttct   6780

agccggcccc ctctccaggg gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac   6840

cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc aacctctgac   6900

gttctgcgcc ttcctaggag agtcttacat gtgttgagat ttcacaagca atgcgagttg   6960

taaaatacca gctctacaag aagctaggct ctgtgacggc atagttttca gtagctttat   7020

cacaatattc acaatggaga attatatgac atggtagcag aaataggccc ttttatgtgt   7080

tgcttctatt ttacctcaaa ttgtagatat agggtaatca ataaaatcca tccatgcctt   7140

tcacacacta agt                                                      7153


<210>  4991
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  4991

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535


<210>  4992
<211>  4355
<212>  DNA
<213>  Homo sapiens

<400>  4992
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1980

catatcctgt gtttgaatca aacccggagt tcttgtatgt ggaaggcttg ccagagggga   2040

ttcccttccg aagccctacc tggtttggaa ttccacgact tgaaaggatc gtccgcggga   2100

gtaataaaat caagttcgtt gttaaaaaac ctgaactagt tatttcctac ttgcctcctg   2160

ggatggctag taaaataaac actaaagctt tgcagtcccc caaaagacca cgaagtcctg   2220

ggagtaattc aaaggttcct gaaattgagg tcaccgtgga aggccctaat aacaacaatc   2280

ctcaaacctc agctgttcga accccgaccc agactaacgg ttctaacgtt cccttcaagc   2340

cacgagggag agagttttcc tttgaggcct ggaatgccaa aatcacggac ctaaaacaga   2400

aagttgaaaa tctcttcaat gagaaatgtg gggaagctct tggccttaaa caagctgtga   2460

aggtgccgtt cgcgttattt gagtctttcc cggaagactt ttatgtggaa ggcttacctg   2520

agggtgtgcc attccgaaga ccatcgactt ttggcattcc gaggctggag aagatactca   2580

gaaacaaagc caaaattaag ttcatcatta aaaagcccga aatgtttgag acggcgatta   2640

aggagagcac ctcctctaag agccctccca gaaaaataaa ttcatcaccc aatgttaata   2700

ctactgcatc aggtgttgaa gaccttaaca tcattcaggt gacaattcca gatgatgata   2760

atgaaagact ctcgaaagtt gaaaaagcta gacagctaag agaacaagtg aatgacctct   2820

ttagtcggaa atttggtgaa gctattggta tgggttttcc tgtgaaagtt ccctacagga   2880

aaatcacaat taaccctggc tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca   2940

aagcccccag ctacctggaa atcagctcca tgagaaggat cttagactct gccgagttta   3000

tcaaattcac ggtcattaga ccatttccag gacttgtgat taataaccag ctggttgatc   3060

agagtgagtc agaaggcccc gtgatacaag aatcagctga accaagccag ttggaagttc   3120

cagccacaga agaaataaaa gagactgatg gaagctctca gatcaagcaa gaaccagacc   3180

ccacgtggta gacctcttcc ctcctaggct taaagtatca gtggttgaga agagcttttc   3240

ggacctgtta ctaccccaag ctgtgtaata tacttgtata acagaaatac cttctataca   3300

aacctttttt tctactttta gatagaaatg tctacttttt cagcagttct gtgaattaaa   3360

gagcagagtg actgtgggtc tggaatggct ggtgtacttg ggaatgtact atcaggattt   3420

tacagcaatg ctgggaaatg acagggaaaa tgacaggaat gaatctcacc agatttttta   3480

tgtactcagc agagccttga gttacggtgt ttattttcca atcaagtgaa gatatctcct   3540

acttctccta ctggaacatc tcagcttctg cagtgaagaa aaattcctgt gatagttcag   3600

ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa tgatcctttg ttcacggctc   3660

tccttaatga ctgagtgaac agttcctatc tgtatatttg actaaacctt ttcctaagct   3720

atctctcatg gttcctatgt ttttttatca taattaaaag caaaaccatc tggatcacct   3780

aacagtcaga ggtcagtatc tcagcgtgtg aattatagag gaaatacaga gagaacctct   3840

tccactttta cttttcgtcc aaataaaatg catggtgtac cagaagttga agatcgggtt   3900

gaggattggg gctagctcga tgacactaag gccccaacat cgcgggacct gctgtggcgc   3960

ggattcttag gaacgctgtt ctagccggcc ccctctccag gggtcgccgt ggccggcatt   4020

atttcctagt tcttcttgta accctgaggt gccagcgcgg ggagtgagga ggggtcaggg   4080

ggctaaggat gcaacctctg acgttctgcg ccttcctagg agagtcttac atgtgttgag   4140

atttcacaag caatgcgagt tgtaaaatac cagctctaca agaagctagg ctctgtgacg   4200

gcatagtttt cagtagcttt atcacaatat tcacaatgga gaattatatg acatggtagc   4260

agaaataggc ccttttatgt gttgcttcta ttttacctca aattgtagat atagggtaat   4320

caataaaatc catccatgcc tttcacacac taagt                              4355


<210>  4993
<211>  977
<212>  PRT
<213>  Homo sapiens

<400>  4993

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
                565                 570                 575


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
            580                 585                 590


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
        595                 600                 605


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
    610                 615                 620


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
625                 630                 635                 640


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
                645                 650                 655


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
            660                 665                 670


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
        675                 680                 685


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
    690                 695                 700


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
705                 710                 715                 720


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
                725                 730                 735


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
            740                 745                 750


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
        755                 760                 765


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
    770                 775                 780


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
785                 790                 795                 800


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
                805                 810                 815


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
            820                 825                 830


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
        835                 840                 845


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
    850                 855                 860


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
865                 870                 875                 880


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
                885                 890                 895


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
            900                 905                 910


Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile 
        915                 920                 925


Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln 
    930                 935                 940


Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile 
945                 950                 955                 960


Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr 
                965                 970                 975


Trp 



<210>  4994
<211>  5059
<212>  DNA
<213>  Homo sapiens

<400>  4994
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040

taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2100

ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2160

ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2220

ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2280

ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2340

atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2400

agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2460

agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2520

tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2580

ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2640

tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2700

ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2760

atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2820

ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2880

tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   2940

ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   3000

tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3060

ttatcaaatt cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg   3120

atcagagtga gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag   3180

ttccagccac agaaggtaaa aggacctctt ccctcctagg gtaaatcagc ttctgtgtca   3240

gggatgctgt gtggtgtcca tctgaacccc ctgcatacgc gtagctaatg tgatctcccc   3300

actttcacat aagatggtgg ccctgccttc agggaatgtg ggagccaggt gggagccttc   3360

ccggatattt aagctagaag attctacagg gagattctcc ttggatcaat atatgtctct   3420

cagtcaaaga tgtaaaagca cttttgcctt aaaaagaatg ttctgtttct aaatagagtc   3480

aacgttgtcc tcctcattgg aattcactat gagtcagaat cattagactg actttttttt   3540

ttccatagta atagtatttt gcagagtctc acagagctgc agatcttttg ttcatcttgc   3600

agagttaaca agtctgatcc tgttagtcca gatttcttaa atttggccaa gttataatag   3660

gagcagtagc ttgagacccg aagtcaggaa actttgacaa tggatttttt tttttaatcc   3720

agagacttgt actggaattt gccttaccct gtcagctcat ggacttaagg tttcatcccg   3780

ctttatgagt gcttctgaat ccaagtcatt gttacctgaa tttgcaaatt aagttgtgat   3840

attcgtgact gttaaattcc tgtaattaga ttaacctctt tgcttgcttg tttgttttct   3900

ctcctatttt agcttaaagt atcagtggtt gagaagagct tttcggacct gttactaccc   3960

caagctgtgt aatatacttg tataacagaa ataccttcta tacaaacctt tttttctact   4020

tttagataga aatgtctact ttttcagcag ttctgtgaat taaagagcag agtgactgtg   4080

ggtctggaat ggctggtgta cttgggaatg tactatcagg attttacagc aatgctggga   4140

aatgacaggg aaaatgacag gaatgaatct caccagattt tttatgtact cagcagagcc   4200

ttgagttacg gtgtttattt tccaatcaag tgaagatatc tcctacttct cctactggaa   4260

catctcagct tctgcagtga agaaaaattc ctgtgatagt tcagttcttt agtttttcta   4320

tttgaaaaaa aaaaatcatt taaatgatcc tttgttcacg gctctcctta atgactgagt   4380

gaacagttcc tatctgtata tttgactaaa ccttttccta agctatctct catggttcct   4440

atgttttttt atcataatta aaagcaaaac catctggatc acctaacagt cagaggtcag   4500

tatctcagcg tgtgaattat agaggaaata cagagagaac ctcttccact tttacttttc   4560

gtccaaataa aatgcatggt gtaccagaag ttgaagatcg ggttgaggat tggggctagc   4620

tcgatgacac taaggcccca acatcgcggg acctgctgtg gcgcggattc ttaggaacgc   4680

tgttctagcc ggccccctct ccaggggtcg ccgtggccgg cattatttcc tagttcttct   4740

tgtaaccctg aggtgccagc gcggggagtg aggaggggtc agggggctaa ggatgcaacc   4800

tctgacgttc tgcgccttcc taggagagtc ttacatgtgt tgagatttca caagcaatgc   4860

gagttgtaaa ataccagctc tacaagaagc taggctctgt gacggcatag ttttcagtag   4920

ctttatcaca atattcacaa tggagaatta tatgacatgg tagcagaaat aggccctttt   4980

atgtgttgct tctattttac ctcaaattgt agatataggg taatcaataa aatccatcca   5040

tgcctttcac acactaagt                                                5059


<210>  4995
<211>  988
<212>  PRT
<213>  Homo sapiens

<400>  4995

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr 
        595                 600                 605


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe 
    610                 615                 620


Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys 
625                 630                 635                 640


Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly 
                645                 650                 655


Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro 
            660                 665                 670


Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val 
        675                 680                 685


Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro 
    690                 695                 700


Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu 
705                 710                 715                 720


Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys 
                725                 730                 735


Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys 
            740                 745                 750


Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp 
        755                 760                 765


Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser 
    770                 775                 780


Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys 
785                 790                 795                 800


Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys 
                805                 810                 815


Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro 
            820                 825                 830


Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln 
        835                 840                 845


Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys 
    850                 855                 860


Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe 
865                 870                 875                 880


Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys 
                885                 890                 895


Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly 
            900                 905                 910


Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg 
        915                 920                 925


Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe 
    930                 935                 940


Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu 
945                 950                 955                 960


Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro 
                965                 970                 975


Ala Thr Glu Gly Lys Arg Thr Ser Ser Leu Leu Gly 
            980                 985


<210>  4996
<211>  4932
<212>  DNA
<213>  Homo sapiens

<400>  4996
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1080

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1140

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1200

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1260

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1320

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1380

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1440

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1500

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1560

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1620

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1680

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1740

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1800

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1860

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1920

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   1980

taccatatcc tgtgtttgaa tcaaacccgg agttcttgaa aggatcgtcc gcgggagtaa   2040

taaaatcaag ttcgttgtta aaaaacctga actagttatt tcctacttgc ctcctgggat   2100

ggctagtaaa ataaacacta aagctttgca gtcccccaaa agaccacgaa gtcctgggag   2160

taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc cctaataaca acaatcctca   2220

aacctcagct gttcgaaccc cgacccagac taacggttct aacgttccct tcaagccacg   2280

agggagagag ttttcctttg aggcctggaa tgccaaaatc acggacctaa aacagaaagt   2340

tgaaaatctc ttcaatgaga aatgtgggga agctcttggc cttaaacaag ctgtgaaggt   2400

gccgttcgcg ttatttgagt ctttcccgga agacttttat gtggaaggct tacctgaggg   2460

tgtgccattc cgaagaccat cgacttttgg cattccgagg ctggagaaga tactcagaaa   2520

caaagccaaa attaagttca tcattaaaaa gcccgaaatg tttgagacgg cgattaagga   2580

gagcacctcc tctaagagcc ctcccagaaa aataaattca tcacccaatg ttaatactac   2640

tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca attccagatg atgataatga   2700

aagactctcg aaagttgaaa aagctagaca gctaagagaa caagtgaatg acctctttag   2760

tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg aaagttccct acaggaaaat   2820

cacaattaac cctggctgtg tggtggttga tggcatgccc ccgggggtgt ccttcaaagc   2880

ccccagctac ctggaaatca gctccatgag aaggatctta gactctgccg agtttatcaa   2940

attcacggtc attagaccat ttccaggact tgtgattaat aaccagctgg ttgatcagag   3000

tgagtcagaa ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc   3060

cacagaaggt aaaaggacct cttccctcct agggtaaatc agcttctgtg tcagggatgc   3120

tgtgtggtgt ccatctgaac cccctgcata cgcgtagcta atgtgatctc cccactttca   3180

cataagatgg tggccctgcc ttcagggaat gtgggagcca ggtgggagcc ttcccggata   3240

tttaagctag aagattctac agggagattc tccttggatc aatatatgtc tctcagtcaa   3300

agatgtaaaa gcacttttgc cttaaaaaga atgttctgtt tctaaataga gtcaacgttg   3360

tcctcctcat tggaattcac tatgagtcag aatcattaga ctgacttttt tttttccata   3420

gtaatagtat tttgcagagt ctcacagagc tgcagatctt ttgttcatct tgcagagtta   3480

acaagtctga tcctgttagt ccagatttct taaatttggc caagttataa taggagcagt   3540

agcttgagac ccgaagtcag gaaactttga caatggattt ttttttttaa tccagagact   3600

tgtactggaa tttgccttac cctgtcagct catggactta aggtttcatc ccgctttatg   3660

agtgcttctg aatccaagtc attgttacct gaatttgcaa attaagttgt gatattcgtg   3720

actgttaaat tcctgtaatt agattaacct ctttgcttgc ttgtttgttt tctctcctat   3780

tttagcttaa agtatcagtg gttgagaaga gcttttcgga cctgttacta ccccaagctg   3840

tgtaatatac ttgtataaca gaaatacctt ctatacaaac ctttttttct acttttagat   3900

agaaatgtct actttttcag cagttctgtg aattaaagag cagagtgact gtgggtctgg   3960

aatggctggt gtacttggga atgtactatc aggattttac agcaatgctg ggaaatgaca   4020

gggaaaatga caggaatgaa tctcaccaga ttttttatgt actcagcaga gccttgagtt   4080

acggtgttta ttttccaatc aagtgaagat atctcctact tctcctactg gaacatctca   4140

gcttctgcag tgaagaaaaa ttcctgtgat agttcagttc tttagttttt ctatttgaaa   4200

aaaaaaaatc atttaaatga tcctttgttc acggctctcc ttaatgactg agtgaacagt   4260

tcctatctgt atatttgact aaaccttttc ctaagctatc tctcatggtt cctatgtttt   4320

tttatcataa ttaaaagcaa aaccatctgg atcacctaac agtcagaggt cagtatctca   4380

gcgtgtgaat tatagaggaa atacagagag aacctcttcc acttttactt ttcgtccaaa   4440

taaaatgcat ggtgtaccag aagttgaaga tcgggttgag gattggggct agctcgatga   4500

cactaaggcc ccaacatcgc gggacctgct gtggcgcgga ttcttaggaa cgctgttcta   4560

gccggccccc tctccagggg tcgccgtggc cggcattatt tcctagttct tcttgtaacc   4620

ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc taaggatgca acctctgacg   4680

ttctgcgcct tcctaggaga gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt   4740

aaaataccag ctctacaaga agctaggctc tgtgacggca tagttttcag tagctttatc   4800

acaatattca caatggagaa ttatatgaca tggtagcaga aataggccct tttatgtgtt   4860

gcttctattt tacctcaaat tgtagatata gggtaatcaa taaaatccat ccatgccttt   4920

cacacactaa gt                                                       4932


<210>  4997
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  4997

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala 
            580                 585                 590


Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600                 605


<210>  4998
<211>  4223
<212>  DNA
<213>  Homo sapiens

<400>  4998
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1080

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1140

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1200

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1260

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1320

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1380

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1440

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1500

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1560

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1620

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1680

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1740

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1800

cgaatacacc agctcaagct cttggactca ccgaggcagt aaaagtacca tatcctgtgt   1860

ttgaatcaaa cccggagttc ttgtatgtgg aaggcttgcc agaggggatt cccttccgaa   1920

gccctacctg gtttggaatt ccacgacttg aaaggatcgt ccgcgggagt aataaaatca   1980

agttcgttgt taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta   2040

aaataaacac taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa   2100

aggttcctga aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag   2160

ctgttcgaac cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag   2220

agttttcctt tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc   2280

tcttcaatga gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg   2340

cgttatttga gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat   2400

tccgaagacc atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca   2460

aaattaagtt catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct   2520

cctctaagag ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag   2580

gtgttgaaga ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct   2640

cgaaagttga aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat   2700

ttggtgaagc tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta   2760

accctggctg tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct   2820

acctggaaat cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg   2880

tcattagacc atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag   2940

aaggccccgt gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag   3000

aaataaaaga gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga   3060

cctcttccct cctaggctta aagtatcagt ggttgagaag agcttttcgg acctgttact   3120

accccaagct gtgtaatata cttgtataac agaaatacct tctatacaaa cctttttttc   3180

tacttttaga tagaaatgtc tactttttca gcagttctgt gaattaaaga gcagagtgac   3240

tgtgggtctg gaatggctgg tgtacttggg aatgtactat caggatttta cagcaatgct   3300

gggaaatgac agggaaaatg acaggaatga atctcaccag attttttatg tactcagcag   3360

agccttgagt tacggtgttt attttccaat caagtgaaga tatctcctac ttctcctact   3420

ggaacatctc agcttctgca gtgaagaaaa attcctgtga tagttcagtt ctttagtttt   3480

tctatttgaa aaaaaaaaat catttaaatg atcctttgtt cacggctctc cttaatgact   3540

gagtgaacag ttcctatctg tatatttgac taaacctttt cctaagctat ctctcatggt   3600

tcctatgttt ttttatcata attaaaagca aaaccatctg gatcacctaa cagtcagagg   3660

tcagtatctc agcgtgtgaa ttatagagga aatacagaga gaacctcttc cacttttact   3720

tttcgtccaa ataaaatgca tggtgtacca gaagttgaag atcgggttga ggattggggc   3780

tagctcgatg acactaaggc cccaacatcg cgggacctgc tgtggcgcgg attcttagga   3840

acgctgttct agccggcccc ctctccaggg gtcgccgtgg ccggcattat ttcctagttc   3900

ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc   3960

aacctctgac gttctgcgcc ttcctaggag agtcttacat gtgttgagat ttcacaagca   4020

atgcgagttg taaaatacca gctctacaag aagctaggct ctgtgacggc atagttttca   4080

gtagctttat cacaatattc acaatggaga attatatgac atggtagcag aaataggccc   4140

ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat agggtaatca ataaaatcca   4200

tccatgcctt tcacacacta agt                                           4223


<210>  4999
<211>  933
<212>  PRT
<213>  Homo sapiens

<400>  4999

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
        515                 520                 525


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
    530                 535                 540


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
545                 550                 555                 560


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
                565                 570                 575


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
            580                 585                 590


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
        595                 600                 605


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
    610                 615                 620


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
625                 630                 635                 640


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
                645                 650                 655


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
            660                 665                 670


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
        675                 680                 685


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
    690                 695                 700


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
705                 710                 715                 720


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
                725                 730                 735


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
            740                 745                 750


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
        755                 760                 765


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
    770                 775                 780


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
785                 790                 795                 800


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
                805                 810                 815


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
            820                 825                 830


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
        835                 840                 845


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
    850                 855                 860


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro 
865                 870                 875                 880


Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly 
                885                 890                 895


Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala 
            900                 905                 910


Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu 
        915                 920                 925


Pro Asp Pro Thr Trp 
    930


<210>  5000
<211>  4927
<212>  DNA
<213>  Homo sapiens

<400>  5000
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1080

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1140

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1200

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1260

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1320

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1380

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1440

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1500

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1560

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1620

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1680

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1740

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1800

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1860

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   1920

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   1980

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2040

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2100

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2160

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2220

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2280

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2340

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2400

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2460

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2520

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2580

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2640

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2700

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2760

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2820

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   2880

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   2940

cggtcattag accatttcca ggacttgtga ttaataacca gctggttgat cagagtgagt   3000

cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt ccagccacag   3060

aaggtaaaag gacctcttcc ctcctagggt aaatcagctt ctgtgtcagg gatgctgtgt   3120

ggtgtccatc tgaaccccct gcatacgcgt agctaatgtg atctccccac tttcacataa   3180

gatggtggcc ctgccttcag ggaatgtggg agccaggtgg gagccttccc ggatatttaa   3240

gctagaagat tctacaggga gattctcctt ggatcaatat atgtctctca gtcaaagatg   3300

taaaagcact tttgccttaa aaagaatgtt ctgtttctaa atagagtcaa cgttgtcctc   3360

ctcattggaa ttcactatga gtcagaatca ttagactgac tttttttttt ccatagtaat   3420

agtattttgc agagtctcac agagctgcag atcttttgtt catcttgcag agttaacaag   3480

tctgatcctg ttagtccaga tttcttaaat ttggccaagt tataatagga gcagtagctt   3540

gagacccgaa gtcaggaaac tttgacaatg gatttttttt tttaatccag agacttgtac   3600

tggaatttgc cttaccctgt cagctcatgg acttaaggtt tcatcccgct ttatgagtgc   3660

ttctgaatcc aagtcattgt tacctgaatt tgcaaattaa gttgtgatat tcgtgactgt   3720

taaattcctg taattagatt aacctctttg cttgcttgtt tgttttctct cctattttag   3780

cttaaagtat cagtggttga gaagagcttt tcggacctgt tactacccca agctgtgtaa   3840

tatacttgta taacagaaat accttctata caaacctttt tttctacttt tagatagaaa   3900

tgtctacttt ttcagcagtt ctgtgaatta aagagcagag tgactgtggg tctggaatgg   3960

ctggtgtact tgggaatgta ctatcaggat tttacagcaa tgctgggaaa tgacagggaa   4020

aatgacagga atgaatctca ccagattttt tatgtactca gcagagcctt gagttacggt   4080

gtttattttc caatcaagtg aagatatctc ctacttctcc tactggaaca tctcagcttc   4140

tgcagtgaag aaaaattcct gtgatagttc agttctttag tttttctatt tgaaaaaaaa   4200

aaatcattta aatgatcctt tgttcacggc tctccttaat gactgagtga acagttccta   4260

tctgtatatt tgactaaacc ttttcctaag ctatctctca tggttcctat gtttttttat   4320

cataattaaa agcaaaacca tctggatcac ctaacagtca gaggtcagta tctcagcgtg   4380

tgaattatag aggaaataca gagagaacct cttccacttt tacttttcgt ccaaataaaa   4440

tgcatggtgt accagaagtt gaagatcggg ttgaggattg gggctagctc gatgacacta   4500

aggccccaac atcgcgggac ctgctgtggc gcggattctt aggaacgctg ttctagccgg   4560

ccccctctcc aggggtcgcc gtggccggca ttatttccta gttcttcttg taaccctgag   4620

gtgccagcgc ggggagtgag gaggggtcag ggggctaagg atgcaacctc tgacgttctg   4680

cgccttccta ggagagtctt acatgtgttg agatttcaca agcaatgcga gttgtaaaat   4740

accagctcta caagaagcta ggctctgtga cggcatagtt ttcagtagct ttatcacaat   4800

attcacaatg gagaattata tgacatggta gcagaaatag gcccttttat gtgttgcttc   4860

tattttacct caaattgtag atatagggta atcaataaaa tccatccatg cctttcacac   4920

actaagt                                                             4927


<210>  5001
<211>  944
<212>  PRT
<213>  Homo sapiens

<400>  5001

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly 
    530                 535                 540


Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro 
545                 550                 555                 560


Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser 
                565                 570                 575


Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser 
            580                 585                 590


Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr 
        595                 600                 605


Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser 
    610                 615                 620


Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile 
625                 630                 635                 640


Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala 
                645                 650                 655


Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro 
            660                 665                 670


Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp 
        675                 680                 685


Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala 
    690                 695                 700


Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser 
705                 710                 715                 720


Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe 
                725                 730                 735


Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg 
            740                 745                 750


Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu 
        755                 760                 765


Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile 
    770                 775                 780


Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu 
785                 790                 795                 800


Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser 
                805                 810                 815


Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe 
            820                 825                 830


Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val 
        835                 840                 845


Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly 
    850                 855                 860


Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser 
865                 870                 875                 880


Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val 
                885                 890                 895


Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln 
            900                 905                 910


Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln 
        915                 920                 925


Leu Glu Val Pro Ala Thr Glu Gly Lys Arg Thr Ser Ser Leu Leu Gly 
    930                 935                 940


<210>  5002
<211>  4208
<212>  DNA
<213>  Homo sapiens

<400>  5002
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag    960

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1020

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1080

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1140

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1200

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1260

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1320

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1380

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1440

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1500

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1560

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1620

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1680

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1740

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagctc   1800

aagctcttgg actcaccgag gcagtaaaag taccatatcc tgtgtttgaa tcaaacccgg   1860

agttcttgta tgtggaaggc ttgccagagg ggattccctt ccgaagccct acctggtttg   1920

gaattccacg acttgaaagg atcgtccgcg ggagtaataa aatcaagttc gttgttaaaa   1980

aacctgaact agttatttcc tacttgcctc ctgggatggc tagtaaaata aacactaaag   2040

ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa ttcaaaggtt cctgaaattg   2100

aggtcaccgt ggaaggccct aataacaaca atcctcaaac ctcagctgtt cgaaccccga   2160

cccagactaa cggttctaac gttcccttca agccacgagg gagagagttt tcctttgagg   2220

cctggaatgc caaaatcacg gacctaaaac agaaagttga aaatctcttc aatgagaaat   2280

gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc gttcgcgtta tttgagtctt   2340

tcccggaaga cttttatgtg gaaggcttac ctgagggtgt gccattccga agaccatcga   2400

cttttggcat tccgaggctg gagaagatac tcagaaacaa agccaaaatt aagttcatca   2460

ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag cacctcctct aagagccctc   2520

ccagaaaaat aaattcatca cccaatgtta atactactgc atcaggtgtt gaagacctta   2580

acatcattca ggtgacaatt ccagatgatg ataatgaaag actctcgaaa gttgaaaaag   2640

ctagacagct aagagaacaa gtgaatgacc tctttagtcg gaaatttggt gaagctattg   2700

gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac aattaaccct ggctgtgtgg   2760

tggttgatgg catgcccccg ggggtgtcct tcaaagcccc cagctacctg gaaatcagct   2820

ccatgagaag gatcttagac tctgccgagt ttatcaaatt cacggtcatt agaccatttc   2880

caggacttgt gattaataac cagctggttg atcagagtga gtcagaaggc cccgtgatac   2940

aagaatcagc tgaaccaagc cagttggaag ttccagccac agaagaaata aaagagactg   3000

atggaagctc tcagatcaag caagaaccag accccacgtg gtagacctct tccctcctag   3060

gcttaaagta tcagtggttg agaagagctt ttcggacctg ttactacccc aagctgtgta   3120

atatacttgt ataacagaaa taccttctat acaaaccttt ttttctactt ttagatagaa   3180

atgtctactt tttcagcagt tctgtgaatt aaagagcaga gtgactgtgg gtctggaatg   3240

gctggtgtac ttgggaatgt actatcagga ttttacagca atgctgggaa atgacaggga   3300

aaatgacagg aatgaatctc accagatttt ttatgtactc agcagagcct tgagttacgg   3360

tgtttatttt ccaatcaagt gaagatatct cctacttctc ctactggaac atctcagctt   3420

ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa   3480

aaaatcattt aaatgatcct ttgttcacgg ctctccttaa tgactgagtg aacagttcct   3540

atctgtatat ttgactaaac cttttcctaa gctatctctc atggttccta tgttttttta   3600

tcataattaa aagcaaaacc atctggatca cctaacagtc agaggtcagt atctcagcgt   3660

gtgaattata gaggaaatac agagagaacc tcttccactt ttacttttcg tccaaataaa   3720

atgcatggtg taccagaagt tgaagatcgg gttgaggatt ggggctagct cgatgacact   3780

aaggccccaa catcgcggga cctgctgtgg cgcggattct taggaacgct gttctagccg   3840

gccccctctc caggggtcgc cgtggccggc attatttcct agttcttctt gtaaccctga   3900

ggtgccagcg cggggagtga ggaggggtca gggggctaag gatgcaacct ctgacgttct   3960

gcgccttcct aggagagtct tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa   4020

taccagctct acaagaagct aggctctgtg acggcatagt tttcagtagc tttatcacaa   4080

tattcacaat ggagaattat atgacatggt agcagaaata ggccctttta tgtgttgctt   4140

ctattttacc tcaaattgta gatatagggt aatcaataaa atccatccat gcctttcaca   4200

cactaagt                                                            4208


<210>  5003
<211>  928
<212>  PRT
<213>  Homo sapiens

<400>  5003

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro 
        515                 520                 525


Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu 
    530                 535                 540


Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu 
545                 550                 555                 560


Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro 
                565                 570                 575


Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn 
            580                 585                 590


Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn 
        595                 600                 605


Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn 
    610                 615                 620


Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser 
625                 630                 635                 640


Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp 
                645                 650                 655


Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn 
            660                 665                 670


Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro 
        675                 680                 685


Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu 
    690                 695                 700


Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg 
705                 710                 715                 720


Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys 
                725                 730                 735


Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys 
            740                 745                 750


Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala 
        755                 760                 765


Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp 
    770                 775                 780


Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu 
785                 790                 795                 800


Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met 
                805                 810                 815


Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly 
            820                 825                 830


Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro 
        835                 840                 845


Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu 
    850                 855                 860


Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn 
865                 870                 875                 880


Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu 
                885                 890                 895


Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys 
            900                 905                 910


Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
        915                 920                 925


<210>  5004
<211>  7871
<212>  DNA
<213>  Homo sapiens

<400>  5004
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040

taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2100

ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2160

ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2220

ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2280

ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2340

atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2400

agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2460

agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2520

tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2580

ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2640

tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2700

ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2760

atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2820

ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2880

tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   2940

ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   3000

tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3060

ttatcaaatt cacggtcatt aggtaagtga gagtttcctg cttagtcaca ggagcgaatc   3120

tggagctcat gaggctgact cttctaaaat gcagccacag gtagtcatcg aatccggctt   3180

cctatgctgt gcaatcaaca aatcaaaata acttgtgtca tcattagaat gtcagatgtg   3240

cttctacgaa ctaagctgac tcttttaatt ctttggcaaa gggttggcaa actaggactg   3300

tttgccaaat tcaggctgcc tcctattttt agagtcttcc tgaaacacag ctacacccgt   3360

attatccatg gctgctttcc tgtcacagtg agtaagtagc tgggactgag aaggcatggc   3420

ctccaaagtc taaaatattt actctctagc actttgtaga aaaaccttag ctaggcacag   3480

tggctaacgc ctgtaatccc agcattttgg gaggccaagg caggcagatc acctgaggtc   3540

aggagttcca gaccagcctg gccaacatgg tgaaatccca tctctacaaa aataaaacag   3600

ttagctgggc atgatggcgg gtgcctgtaa tcccagctac tcgggaggct gaggcaggat   3660

agtcgcttga acccaggagg tggaggttgc aatgagccaa gatcatgcca ctgcactcca   3720

gcctggacga cagagtgaga ctccatcaca agaaaaaaag aactttgtca acctctgtct   3780

tagggcgcct tgtcacaggc ttcgggtcag acggattcaa ccttgcatca gccatttgtt   3840

agccaggtca ctctgttctt tgtctgtaaa tgagattgat cgttgttccc actgagagtg   3900

tcagctcctt cccgtagagc aggcatgatg attgtactca cctctgacac cattgtgagt   3960

gccacattcc ttcccacgtc cttgtcactg taagagatgc ccacctgagc accaacccca   4020

ggttatcttc ccctttgtct tccagccccc cagaaacagc tacgactcaa cctacccaat   4080

catttcatca tcagattgcc actgtctcta gttcaggtct cttgggactg gcactcagaa   4140

atctcataat aaatcctctt gaggcttctc atacactcgt cttcttccaa tcttctttcc   4200

ctcaaaatct catattttgg ttccacttca cccaccgtca ttctccatat cactcccagg   4260

agttaggcaa aaagcccctt ccgttcttcc gtatgttaaa cttagaatca ctctgttccc   4320

tgctctgcgt ttctattttt tgtttttcct ccatttacta gtagcttaac actttctaac   4380

agtgttctta ttattgatac gtatctatct cttccataag cttataaggt cacggataat   4440

acttctcatt gtagtacgta aatgacgtgg gctagatatg agttgaataa acagttatac   4500

ctgtaaattc ttacagagtg aaaataaatt gttatacttt acaatttgtt tctctcttta   4560

gaccatttcc aggacttgtg attaataacc gtgagtattt tgtgaagtgt tttgtttttg   4620

ttttttcctg gggtctgacg tgtgtgcgtg tgagtgtgta tacatgctta acgtatatca   4680

cgttacttca cctatgtcag taaccaggcc aaatacttgt tttagccctc agtaaaaaca   4740

ccaggcactt cctagttgta aaattattca agcttcttaa cttcctatcc tcgatgcact   4800

taatcataaa atggtaataa tagcaccgat tttgggggag tcgttccagt agatggaaag   4860

catctggaac aggtgtcagc aagctcctgc cgacgtgtat gcataaagtt ttattgaaac   4920

caccatcgtg tccatttgtt tatggcagaa ctgagagatg gcagcagcaa gtgtgtgcct   4980

gcaaaaccta aaatatttac taattggctc tgcaagaaaa gagtttgcat ccccctaacc   5040

tagaacagtg tctagcctct agtatgtgtt tagcctacag tatgtgctca gcgaatacaa   5100

tctatattta ttactgcttt tatgactgtt ataattactg tgcttggatt tcgttacaaa   5160

gtaagtcaca atgtgcctgc ttctgttagt atttcagcac agtgcctggc acacatgggg   5220

ctctcaaata ttgctgagcg agtgaacaaa tgtcctttca attccttaac gttgatgtca   5280

ttttcaatag tattttgagc caaacttaat tttgcgagtg tgttttgttt tcttaacttt   5340

attattaaaa atgtataaaa gtgaggccag gcgtggtggc tcacgcctgt aatcccagca   5400

gtttgggagg ctgaggcagg cggatcagtt gaggttggga gttggagacc agcccgtcca   5460

acatggtgaa agcctgtctc tactaaaaat acaaaaatca gctgggtgtg gtggcgcgtg   5520

cctgtaatcc cagctactca ggaggctgag gcaggagagt tgcttgaatc ctagaggtgg   5580

aggttgcagt gagctgagat cgtgccattg cactccagcc tgggcaacaa gagcaaaact   5640

ctgtcccaat aaataaataa ataaaatgtt ctcttttgtt cctgttcttg tgcggtagtg   5700

tggtatagag ttttatggta attactgtga attagtgatt ctgagggaca tatcagaact   5760

ctgaggtttg tttccttctc atcttgaggg aaacagcaaa tgtatgttaa aatgcttttc   5820

caagggaaca acacatcctt acattattta aaccaatctg cttcattttc agagctggtt   5880

gatcagagtg agtcagaagg ccccgtgata caagaatcag ctgaaccaag ccagttggaa   5940

gttccagcca cagaagaaat aaaagagact gatggaagct ctcagatcaa gcaagaacca   6000

gaccccacgt ggtagacctc ttccctccta gggtaaatca gcttctgtgt cagggatgct   6060

gtgtggtgtc catctgaacc ccctgcatac gcgtagctaa tgtgatctcc ccactttcac   6120

ataagatggt ggccctgcct tcagggaatg tgggagccag gtgggagcct tcccggatat   6180

ttaagctaga agattctaca gggagattct ccttggatca atatatgtct ctcagtcaaa   6240

gatgtaaaag cacttttgcc ttaaaaagaa tgttctgttt ctaaatagag tcaacgttgt   6300

cctcctcatt ggaattcact atgagtcaga atcattagac tgactttttt ttttccatag   6360

taatagtatt ttgcagagtc tcacagagct gcagatcttt tgttcatctt gcagagttaa   6420

caagtctgat cctgttagtc cagatttctt aaatttggcc aagttataat aggagcagta   6480

gcttgagacc cgaagtcagg aaactttgac aatggatttt tttttttaat ccagagactt   6540

gtactggaat ttgccttacc ctgtcagctc atggacttaa ggtttcatcc cgctttatga   6600

gtgcttctga atccaagtca ttgttacctg aatttgcaaa ttaagttgtg atattcgtga   6660

ctgttaaatt cctgtaatta gattaacctc tttgcttgct tgtttgtttt ctctcctatt   6720

ttagcttaaa gtatcagtgg ttgagaagag cttttcggac ctgttactac cccaagctgt   6780

gtaatatact tgtataacag aaataccttc tatacaaacc tttttttcta cttttagata   6840

gaaatgtcta ctttttcagc agttctgtga attaaagagc agagtgactg tgggtctgga   6900

atggctggtg tacttgggaa tgtactatca ggattttaca gcaatgctgg gaaatgacag   6960

ggaaaatgac aggaatgaat ctcaccagat tttttatgta ctcagcagag ccttgagtta   7020

cggtgtttat tttccaatca agtgaagata tctcctactt ctcctactgg aacatctcag   7080

cttctgcagt gaagaaaaat tcctgtgata gttcagttct ttagtttttc tatttgaaaa   7140

aaaaaaatca tttaaatgat cctttgttca cggctctcct taatgactga gtgaacagtt   7200

cctatctgta tatttgacta aaccttttcc taagctatct ctcatggttc ctatgttttt   7260

ttatcataat taaaagcaaa accatctgga tcacctaaca gtcagaggtc agtatctcag   7320

cgtgtgaatt atagaggaaa tacagagaga acctcttcca cttttacttt tcgtccaaat   7380

aaaatgcatg gtgtaccaga agttgaagat cgggttgagg attggggcta gctcgatgac   7440

actaaggccc caacatcgcg ggacctgctg tggcgcggat tcttaggaac gctgttctag   7500

ccggccccct ctccaggggt cgccgtggcc ggcattattt cctagttctt cttgtaaccc   7560

tgaggtgcca gcgcggggag tgaggagggg tcagggggct aaggatgcaa cctctgacgt   7620

tctgcgcctt cctaggagag tcttacatgt gttgagattt cacaagcaat gcgagttgta   7680

aaataccagc tctacaagaa gctaggctct gtgacggcat agttttcagt agctttatca   7740

caatattcac aatggagaat tatatgacat ggtagcagaa ataggccctt ttatgtgttg   7800

cttctatttt acctcaaatt gtagatatag ggtaatcaat aaaatccatc catgcctttc   7860

acacactaag t                                                        7871


<210>  5005
<211>  942
<212>  PRT
<213>  Homo sapiens

<400>  5005

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr 
        595                 600                 605


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe 
    610                 615                 620


Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys 
625                 630                 635                 640


Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly 
                645                 650                 655


Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro 
            660                 665                 670


Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val 
        675                 680                 685


Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro 
    690                 695                 700


Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu 
705                 710                 715                 720


Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys 
                725                 730                 735


Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys 
            740                 745                 750


Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp 
        755                 760                 765


Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser 
    770                 775                 780


Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys 
785                 790                 795                 800


Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys 
                805                 810                 815


Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro 
            820                 825                 830


Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln 
        835                 840                 845


Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys 
    850                 855                 860


Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe 
865                 870                 875                 880


Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys 
                885                 890                 895


Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly 
            900                 905                 910


Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg 
        915                 920                 925


Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
    930                 935                 940


<210>  5006
<211>  7056
<212>  DNA
<213>  Homo sapiens

<400>  5006
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1080

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1140

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1200

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1260

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1320

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1380

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1440

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1500

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1560

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1620

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1680

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1740

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1800

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1860

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1920

catatcctgt gtttgaatca aacccggagt tcttgtatgt ggaaggcttg ccagagggga   1980

ttcccttccg aagccctacc tggtttggaa ttccacgact tgaaaggatc gtccgcggga   2040

gtaataaaat caagttcgtt gttaaaaaac ctgaactagt tatttcctac ttgcctcctg   2100

ggatggctag taaaataaac actaaagctt tgcagtcccc caaaagacca cgaagtcctg   2160

ggagtaattc aaaggttcct gaaattgagg tcaccgtgga aggccctaat aacaacaatc   2220

ctcaaacctc agctgttcga accccgaccc agactaacgg ttctaacgtt cccttcaagc   2280

cacgagggag agagttttcc tttgaggcct ggaatgccaa aatcacggac ctaaaacaga   2340

aagttgaaaa tctcttcaat gagaaatgtg gggaagctct tggccttaaa caagctgtga   2400

aggtgccgtt cgcgttattt gagtctttcc cggaagactt ttatgtggaa ggcttacctg   2460

agggtgtgcc attccgaaga ccatcgactt ttggcattcc gaggctggag aagatactca   2520

gaaacaaagc caaaattaag ttcatcatta aaaagcccga aatgtttgag acggcgatta   2580

aggagagcac ctcctctaag agccctccca gaaaaataaa ttcatcaccc aatgttaata   2640

ctactgcatc aggtgttgaa gaccttaaca tcattcaggt gacaattcca gatgatgata   2700

atgaaagact ctcgaaagtt gaaaaagcta gacagctaag agaacaagtg aatgacctct   2760

ttagtcggaa atttggtgaa gctattggta tgggttttcc tgtgaaagtt ccctacagga   2820

aaatcacaat taaccctggc tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca   2880

aagcccccag ctacctggaa atcagctcca tgagaaggat cttagactct gccgagttta   2940

tcaaattcac ggtcattagg taagtgagag tttcctgctt agtcacagga gcgaatctgg   3000

agctcatgag gctgactctt ctaaaatgca gccacaggta gtcatcgaat ccggcttcct   3060

atgctgtgca atcaacaaat caaaataact tgtgtcatca ttagaatgtc agatgtgctt   3120

ctacgaacta agctgactct tttaattctt tggcaaaggg ttggcaaact aggactgttt   3180

gccaaattca ggctgcctcc tatttttaga gtcttcctga aacacagcta cacccgtatt   3240

atccatggct gctttcctgt cacagtgagt aagtagctgg gactgagaag gcatggcctc   3300

caaagtctaa aatatttact ctctagcact ttgtagaaaa accttagcta ggcacagtgg   3360

ctaacgcctg taatcccagc attttgggag gccaaggcag gcagatcacc tgaggtcagg   3420

agttccagac cagcctggcc aacatggtga aatcccatct ctacaaaaat aaaacagtta   3480

gctgggcatg atggcgggtg cctgtaatcc cagctactcg ggaggctgag gcaggatagt   3540

cgcttgaacc caggaggtgg aggttgcaat gagccaagat catgccactg cactccagcc   3600

tggacgacag agtgagactc catcacaaga aaaaaagaac tttgtcaacc tctgtcttag   3660

ggcgccttgt cacaggcttc gggtcagacg gattcaacct tgcatcagcc atttgttagc   3720

caggtcactc tgttctttgt ctgtaaatga gattgatcgt tgttcccact gagagtgtca   3780

gctccttccc gtagagcagg catgatgatt gtactcacct ctgacaccat tgtgagtgcc   3840

acattccttc ccacgtcctt gtcactgtaa gagatgccca cctgagcacc aaccccaggt   3900

tatcttcccc tttgtcttcc agccccccag aaacagctac gactcaacct acccaatcat   3960

ttcatcatca gattgccact gtctctagtt caggtctctt gggactggca ctcagaaatc   4020

tcataataaa tcctcttgag gcttctcata cactcgtctt cttccaatct tctttccctc   4080

aaaatctcat attttggttc cacttcaccc accgtcattc tccatatcac tcccaggagt   4140

taggcaaaaa gccccttccg ttcttccgta tgttaaactt agaatcactc tgttccctgc   4200

tctgcgtttc tattttttgt ttttcctcca tttactagta gcttaacact ttctaacagt   4260

gttcttatta ttgatacgta tctatctctt ccataagctt ataaggtcac ggataatact   4320

tctcattgta gtacgtaaat gacgtgggct agatatgagt tgaataaaca gttatacctg   4380

taaattctta cagagtgaaa ataaattgtt atactttaca atttgtttct ctctttagac   4440

catttccagg acttgtgatt aataaccgtg agtattttgt gaagtgtttt gtttttgttt   4500

tttcctgggg tctgacgtgt gtgcgtgtga gtgtgtatac atgcttaacg tatatcacgt   4560

tacttcacct atgtcagtaa ccaggccaaa tacttgtttt agccctcagt aaaaacacca   4620

ggcacttcct agttgtaaaa ttattcaagc ttcttaactt cctatcctcg atgcacttaa   4680

tcataaaatg gtaataatag caccgatttt gggggagtcg ttccagtaga tggaaagcat   4740

ctggaacagg tgtcagcaag ctcctgccga cgtgtatgca taaagtttta ttgaaaccac   4800

catcgtgtcc atttgtttat ggcagaactg agagatggca gcagcaagtg tgtgcctgca   4860

aaacctaaaa tatttactaa ttggctctgc aagaaaagag tttgcatccc cctaacctag   4920

aacagtgtct agcctctagt atgtgtttag cctacagtat gtgctcagcg aatacaatct   4980

atatttatta ctgcttttat gactgttata attactgtgc ttggatttcg ttacaaagta   5040

agtcacaatg tgcctgcttc tgttagtatt tcagcacagt gcctggcaca catggggctc   5100

tcaaatattg ctgagcgagt gaacaaatgt cctttcaatt ccttaacgtt gatgtcattt   5160

tcaatagtat tttgagccaa acttaatttt gcgagtgtgt tttgttttct taactttatt   5220

attaaaaatg tataaaagtg aggccaggcg tggtggctca cgcctgtaat cccagcagtt   5280

tgggaggctg aggcaggcgg atcagttgag gttgggagtt ggagaccagc ccgtccaaca   5340

tggtgaaagc ctgtctctac taaaaataca aaaatcagct gggtgtggtg gcgcgtgcct   5400

gtaatcccag ctactcagga ggctgaggca ggagagttgc ttgaatccta gaggtggagg   5460

ttgcagtgag ctgagatcgt gccattgcac tccagcctgg gcaacaagag caaaactctg   5520

tcccaataaa taaataaata aaatgttctc ttttgttcct gttcttgtgc ggtagtgtgg   5580

tatagagttt tatggtaatt actgtgaatt agtgattctg agggacatat cagaactctg   5640

aggtttgttt ccttctcatc ttgagggaaa cagcaaatgt atgttaaaat gcttttccaa   5700

gggaacaaca catccttaca ttatttaaac caatctgctt cattttcaga gctggttgat   5760

cagagtgagt cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt   5820

ccagccacag aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac   5880

cccacgtggt agacctcttc cctcctaggc ttaaagtatc agtggttgag aagagctttt   5940

cggacctgtt actaccccaa gctgtgtaat atacttgtat aacagaaata ccttctatac   6000

aaaccttttt ttctactttt agatagaaat gtctactttt tcagcagttc tgtgaattaa   6060

agagcagagt gactgtgggt ctggaatggc tggtgtactt gggaatgtac tatcaggatt   6120

ttacagcaat gctgggaaat gacagggaaa atgacaggaa tgaatctcac cagatttttt   6180

atgtactcag cagagccttg agttacggtg tttattttcc aatcaagtga agatatctcc   6240

tacttctcct actggaacat ctcagcttct gcagtgaaga aaaattcctg tgatagttca   6300

gttctttagt ttttctattt gaaaaaaaaa aatcatttaa atgatccttt gttcacggct   6360

ctccttaatg actgagtgaa cagttcctat ctgtatattt gactaaacct tttcctaagc   6420

tatctctcat ggttcctatg tttttttatc ataattaaaa gcaaaaccat ctggatcacc   6480

taacagtcag aggtcagtat ctcagcgtgt gaattataga ggaaatacag agagaacctc   6540

ttccactttt acttttcgtc caaataaaat gcatggtgta ccagaagttg aagatcgggt   6600

tgaggattgg ggctagctcg atgacactaa ggccccaaca tcgcgggacc tgctgtggcg   6660

cggattctta ggaacgctgt tctagccggc cccctctcca ggggtcgccg tggccggcat   6720

tatttcctag ttcttcttgt aaccctgagg tgccagcgcg gggagtgagg aggggtcagg   6780

gggctaagga tgcaacctct gacgttctgc gccttcctag gagagtctta catgtgttga   6840

gatttcacaa gcaatgcgag ttgtaaaata ccagctctac aagaagctag gctctgtgac   6900

ggcatagttt tcagtagctt tatcacaata ttcacaatgg agaattatat gacatggtag   6960

cagaaatagg cccttttatg tgttgcttct attttacctc aaattgtaga tatagggtaa   7020

tcaataaaat ccatccatgc ctttcacaca ctaagt                             7056


<210>  5007
<211>  901
<212>  PRT
<213>  Homo sapiens

<400>  5007

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
                565                 570                 575


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
            580                 585                 590


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
        595                 600                 605


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
    610                 615                 620


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
625                 630                 635                 640


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
                645                 650                 655


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
            660                 665                 670


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
        675                 680                 685


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
    690                 695                 700


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
705                 710                 715                 720


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
                725                 730                 735


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
            740                 745                 750


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
        755                 760                 765


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
    770                 775                 780


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
785                 790                 795                 800


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
                805                 810                 815


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
            820                 825                 830


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
        835                 840                 845


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
    850                 855                 860


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
865                 870                 875                 880


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
                885                 890                 895


Phe Thr Val Ile Arg 
            900


<210>  5008
<211>  3915
<212>  DNA
<213>  Homo sapiens

<400>  5008
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgcttaga tttgttgaca gcggtttcct ggagtgctgt   1980

cttgagaacg attctgagga ggctcagcaa gaaagagtgt ttcagttgat tgggtgtgtc   2040

tgtcatggag aaggaactca agctcttgga ctcaccgagg cagtaaaagt accatatcct   2100

gtgtttgaat caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc   2160

cgaagcccta cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa   2220

atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct   2280

agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat   2340

tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc   2400

tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg   2460

agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa   2520

aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg   2580

ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg   2640

ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa   2700

gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc   2760

acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca   2820

tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga   2880

ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg   2940

aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca   3000

attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt caaagccccc   3060

agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc   3120

acggtcatta gaccatttcc aggacttgtg attaataacc agctggttga tcagagtgag   3180

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   3240

gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga ccccacgtgg   3300

tagacctctt ccctcctagg caaaaccatc tggatcacct aacagtcaga ggtcagtatc   3360

tcagcgtgtg aattatagag gaaatacaga gagaacctct tccactttta cttttcgtcc   3420

aaataaaatg catggtgtac cagaagttga agatcgggtt gaggattggg gctagctcga   3480

tgacactaag gccccaacat cgcgggacct gctgtggcgc ggattcttag gaacgctgtt   3540

ctagccggcc ccctctccag gggtcgccgt ggccggcatt atttcctagt tcttcttgta   3600

accctgaggt gccagcgcgg ggagtgagga ggggtcaggg ggctaaggat gcaacctctg   3660

acgttctgcg ccttcctagg agagtcttac atgtgttgag atttcacaag caatgcgagt   3720

tgtaaaatac cagctctaca agaagctagg ctctgtgacg gcatagtttt cagtagcttt   3780

atcacaatat tcacaatgga gaattatatg acatggtagc agaaataggc ccttttatgt   3840

gttgcttcta ttttacctca aattgtagat atagggtaat caataaaatc catccatgcc   3900

tttcacacac taagt                                                    3915


<210>  5009
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  5009

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala 



<210>  5010
<211>  6984
<212>  DNA
<213>  Homo sapiens

<400>  5010
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1080

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1140

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1200

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1260

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1320

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1380

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1440

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1500

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1560

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1620

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1680

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1740

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1800

cgaatacacc agctcaagct cttggactca ccgaggcagt aaaagtacca tatcctgtgt   1860

ttgaatcaaa cccggagttc ttgtatgtgg aaggcttgcc agaggggatt cccttccgaa   1920

gccctacctg gtttggaatt ccacgacttg aaaggatcgt ccgcgggagt aataaaatca   1980

agttcgttgt taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta   2040

aaataaacac taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa   2100

aggttcctga aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag   2160

ctgttcgaac cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag   2220

agttttcctt tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc   2280

tcttcaatga gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg   2340

cgttatttga gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat   2400

tccgaagacc atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca   2460

aaattaagtt catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct   2520

cctctaagag ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag   2580

gtgttgaaga ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct   2640

cgaaagttga aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat   2700

ttggtgaagc tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta   2760

accctggctg tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct   2820

acctggaaat cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg   2880

tcattaggta agtgagagtt tcctgcttag tcacaggagc gaatctggag ctcatgaggc   2940

tgactcttct aaaatgcagc cacaggtagt catcgaatcc ggcttcctat gctgtgcaat   3000

caacaaatca aaataacttg tgtcatcatt agaatgtcag atgtgcttct acgaactaag   3060

ctgactcttt taattctttg gcaaagggtt ggcaaactag gactgtttgc caaattcagg   3120

ctgcctccta tttttagagt cttcctgaaa cacagctaca cccgtattat ccatggctgc   3180

tttcctgtca cagtgagtaa gtagctggga ctgagaaggc atggcctcca aagtctaaaa   3240

tatttactct ctagcacttt gtagaaaaac cttagctagg cacagtggct aacgcctgta   3300

atcccagcat tttgggaggc caaggcaggc agatcacctg aggtcaggag ttccagacca   3360

gcctggccaa catggtgaaa tcccatctct acaaaaataa aacagttagc tgggcatgat   3420

ggcgggtgcc tgtaatccca gctactcggg aggctgaggc aggatagtcg cttgaaccca   3480

ggaggtggag gttgcaatga gccaagatca tgccactgca ctccagcctg gacgacagag   3540

tgagactcca tcacaagaaa aaaagaactt tgtcaacctc tgtcttaggg cgccttgtca   3600

caggcttcgg gtcagacgga ttcaaccttg catcagccat ttgttagcca ggtcactctg   3660

ttctttgtct gtaaatgaga ttgatcgttg ttcccactga gagtgtcagc tccttcccgt   3720

agagcaggca tgatgattgt actcacctct gacaccattg tgagtgccac attccttccc   3780

acgtccttgt cactgtaaga gatgcccacc tgagcaccaa ccccaggtta tcttcccctt   3840

tgtcttccag ccccccagaa acagctacga ctcaacctac ccaatcattt catcatcaga   3900

ttgccactgt ctctagttca ggtctcttgg gactggcact cagaaatctc ataataaatc   3960

ctcttgaggc ttctcataca ctcgtcttct tccaatcttc tttccctcaa aatctcatat   4020

tttggttcca cttcacccac cgtcattctc catatcactc ccaggagtta ggcaaaaagc   4080

cccttccgtt cttccgtatg ttaaacttag aatcactctg ttccctgctc tgcgtttcta   4140

ttttttgttt ttcctccatt tactagtagc ttaacacttt ctaacagtgt tcttattatt   4200

gatacgtatc tatctcttcc ataagcttat aaggtcacgg ataatacttc tcattgtagt   4260

acgtaaatga cgtgggctag atatgagttg aataaacagt tatacctgta aattcttaca   4320

gagtgaaaat aaattgttat actttacaat ttgtttctct ctttagacca tttccaggac   4380

ttgtgattaa taaccgtgag tattttgtga agtgttttgt ttttgttttt tcctggggtc   4440

tgacgtgtgt gcgtgtgagt gtgtatacat gcttaacgta tatcacgtta cttcacctat   4500

gtcagtaacc aggccaaata cttgttttag ccctcagtaa aaacaccagg cacttcctag   4560

ttgtaaaatt attcaagctt cttaacttcc tatcctcgat gcacttaatc ataaaatggt   4620

aataatagca ccgattttgg gggagtcgtt ccagtagatg gaaagcatct ggaacaggtg   4680

tcagcaagct cctgccgacg tgtatgcata aagttttatt gaaaccacca tcgtgtccat   4740

ttgtttatgg cagaactgag agatggcagc agcaagtgtg tgcctgcaaa acctaaaata   4800

tttactaatt ggctctgcaa gaaaagagtt tgcatccccc taacctagaa cagtgtctag   4860

cctctagtat gtgtttagcc tacagtatgt gctcagcgaa tacaatctat atttattact   4920

gcttttatga ctgttataat tactgtgctt ggatttcgtt acaaagtaag tcacaatgtg   4980

cctgcttctg ttagtatttc agcacagtgc ctggcacaca tggggctctc aaatattgct   5040

gagcgagtga acaaatgtcc tttcaattcc ttaacgttga tgtcattttc aatagtattt   5100

tgagccaaac ttaattttgc gagtgtgttt tgttttctta actttattat taaaaatgta   5160

taaaagtgag gccaggcgtg gtggctcacg cctgtaatcc cagcagtttg ggaggctgag   5220

gcaggcggat cagttgaggt tgggagttgg agaccagccc gtccaacatg gtgaaagcct   5280

gtctctacta aaaatacaaa aatcagctgg gtgtggtggc gcgtgcctgt aatcccagct   5340

actcaggagg ctgaggcagg agagttgctt gaatcctaga ggtggaggtt gcagtgagct   5400

gagatcgtgc cattgcactc cagcctgggc aacaagagca aaactctgtc ccaataaata   5460

aataaataaa atgttctctt ttgttcctgt tcttgtgcgg tagtgtggta tagagtttta   5520

tggtaattac tgtgaattag tgattctgag ggacatatca gaactctgag gtttgtttcc   5580

ttctcatctt gagggaaaca gcaaatgtat gttaaaatgc ttttccaagg gaacaacaca   5640

tccttacatt atttaaacca atctgcttca ttttcagagc tggttgatca gagtgagtca   5700

gaaggccccg tgatacaaga atcagctgaa ccaagccagt tggaagttcc agccacagaa   5760

gaaataaaag agactgatgg aagctctcag atcaagcaag aaccagaccc cacgtggtag   5820

acctcttccc tcctaggctt aaagtatcag tggttgagaa gagcttttcg gacctgttac   5880

taccccaagc tgtgtaatat acttgtataa cagaaatacc ttctatacaa accttttttt   5940

ctacttttag atagaaatgt ctactttttc agcagttctg tgaattaaag agcagagtga   6000

ctgtgggtct ggaatggctg gtgtacttgg gaatgtacta tcaggatttt acagcaatgc   6060

tgggaaatga cagggaaaat gacaggaatg aatctcacca gattttttat gtactcagca   6120

gagccttgag ttacggtgtt tattttccaa tcaagtgaag atatctccta cttctcctac   6180

tggaacatct cagcttctgc agtgaagaaa aattcctgtg atagttcagt tctttagttt   6240

ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt tcacggctct ccttaatgac   6300

tgagtgaaca gttcctatct gtatatttga ctaaaccttt tcctaagcta tctctcatgg   6360

ttcctatgtt tttttatcat aattaaaagc aaaaccatct ggatcaccta acagtcagag   6420

gtcagtatct cagcgtgtga attatagagg aaatacagag agaacctctt ccacttttac   6480

ttttcgtcca aataaaatgc atggtgtacc agaagttgaa gatcgggttg aggattgggg   6540

ctagctcgat gacactaagg ccccaacatc gcgggacctg ctgtggcgcg gattcttagg   6600

aacgctgttc tagccggccc cctctccagg ggtcgccgtg gccggcatta tttcctagtt   6660

cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg gctaaggatg   6720

caacctctga cgttctgcgc cttcctagga gagtcttaca tgtgttgaga tttcacaagc   6780

aatgcgagtt gtaaaatacc agctctacaa gaagctaggc tctgtgacgg catagttttc   6840

agtagcttta tcacaatatt cacaatggag aattatatga catggtagca gaaataggcc   6900

cttttatgtg ttgcttctat tttacctcaa attgtagata tagggtaatc aataaaatcc   6960

atccatgcct ttcacacact aagt                                          6984


<210>  5011
<211>  877
<212>  PRT
<213>  Homo sapiens

<400>  5011

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
        515                 520                 525


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
    530                 535                 540


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
545                 550                 555                 560


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
                565                 570                 575


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
            580                 585                 590


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
        595                 600                 605


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
    610                 615                 620


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
625                 630                 635                 640


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
                645                 650                 655


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
            660                 665                 670


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
        675                 680                 685


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
    690                 695                 700


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
705                 710                 715                 720


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
                725                 730                 735


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
            740                 745                 750


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
        755                 760                 765


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
    770                 775                 780


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
785                 790                 795                 800


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
                805                 810                 815


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
            820                 825                 830


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
        835                 840                 845


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
    850                 855                 860


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
865                 870                 875


<210>  5012
<211>  3743
<212>  DNA
<213>  Homo sapiens

<400>  5012
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1080

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1140

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1200

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1260

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1320

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1380

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1440

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1500

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1560

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1620

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1680

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1740

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1800

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1860

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1920

catatcctgt gtttgaatca aacccggagt tcttgtatgt ggaaggcttg ccagagggga   1980

ttcccttccg aagccctacc tggtttggaa ttccacgact tgaaaggatc gtccgcggga   2040

gtaataaaat caagttcgtt gttaaaaaac ctgaactagt tatttcctac ttgcctcctg   2100

ggatggctag taaaataaac actaaagctt tgcagtcccc caaaagacca cgaagtcctg   2160

ggagtaattc aaaggttcct gaaattgagg tcaccgtgga aggccctaat aacaacaatc   2220

ctcaaacctc agctgttcga accccgaccc agactaacgg ttctaacgtt cccttcaagc   2280

cacgagggag agagttttcc tttgaggcct ggaatgccaa aatcacggac ctaaaacaga   2340

aagttgaaaa tctcttcaat gagaaatgtg gggaagctct tggccttaaa caagctgtga   2400

aggtgccgtt cgcgttattt gagtctttcc cggaagactt ttatgtggaa ggcttacctg   2460

agggtgtgcc attccgaaga ccatcgactt ttggcattcc gaggctggag aagatactca   2520

gaaacaaagc caaaattaag ttcatcatta aaaagcccga aatgtttgag acggcgatta   2580

aggagagcac ctcctctaag agccctccca gaaaaataaa ttcatcaccc aatgttaata   2640

ctactgcatc aggtgttgaa gaccttaaca tcattcaggt gacaattcca gatgatgata   2700

atgaaagact ctcgaaagtt gaaaaagcta gacagctaag agaacaagtg aatgacctct   2760

ttagtcggaa atttggtgaa gctattggta tgggttttcc tgtgaaagtt ccctacagga   2820

aaatcacaat taaccctggc tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca   2880

aagcccccag ctacctggaa atcagctcca tgagaaggat cttagactct gccgagttta   2940

tcaaattcac ggtcattaga ccatttccag gacttgtgat taataaccag ctggttgatc   3000

agagtgagtc agaaggcccc gtgatacaag aatcagctga accaagccag ttggaagttc   3060

cagccacaga agaaataaaa gagactgatg gaagctctca gatcaagcaa gaaccagacc   3120

ccacgtggta gacctcttcc ctcctaggca aaaccatctg gatcacctaa cagtcagagg   3180

tcagtatctc agcgtgtgaa ttatagagga aatacagaga gaacctcttc cacttttact   3240

tttcgtccaa ataaaatgca tggtgtacca gaagttgaag atcgggttga ggattggggc   3300

tagctcgatg acactaaggc cccaacatcg cgggacctgc tgtggcgcgg attcttagga   3360

acgctgttct agccggcccc ctctccaggg gtcgccgtgg ccggcattat ttcctagttc   3420

ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc   3480

aacctctgac gttctgcgcc ttcctaggag agtcttacat gtgttgagat ttcacaagca   3540

atgcgagttg taaaatacca gctctacaag aagctaggct ctgtgacggc atagttttca   3600

gtagctttat cacaatattc acaatggaga attatatgac atggtagcag aaataggccc   3660

ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat agggtaatca ataaaatcca   3720

tccatgcctt tcacacacta agt                                           3743


<210>  5013
<211>  957
<212>  PRT
<213>  Homo sapiens

<400>  5013

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
                565                 570                 575


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
            580                 585                 590


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
        595                 600                 605


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
    610                 615                 620


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
625                 630                 635                 640


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
                645                 650                 655


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
            660                 665                 670


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
        675                 680                 685


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
    690                 695                 700


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
705                 710                 715                 720


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
                725                 730                 735


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
            740                 745                 750


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
        755                 760                 765


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
    770                 775                 780


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
785                 790                 795                 800


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
                805                 810                 815


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
            820                 825                 830


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
        835                 840                 845


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
    850                 855                 860


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
865                 870                 875                 880


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
                885                 890                 895


Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu 
            900                 905                 910


Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu 
        915                 920                 925


Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp 
    930                 935                 940


Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950                 955


<210>  5014
<211>  7808
<212>  DNA
<213>  Homo sapiens

<400>  5014
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1980

catatcctgt gtttgaatca aacccggagt tcttgtatgt ggaaggcttg ccagagggga   2040

ttcccttccg aagccctacc tggtttggaa ttccacgact tgaaaggatc gtccgcggga   2100

gtaataaaat caagttcgtt gttaaaaaac ctgaactagt tatttcctac ttgcctcctg   2160

ggatggctag taaaataaac actaaagctt tgcagtcccc caaaagacca cgaagtcctg   2220

ggagtaattc aaaggttcct gaaattgagg tcaccgtgga aggccctaat aacaacaatc   2280

ctcaaacctc agctgttcga accccgaccc agactaacgg ttctaacgtt cccttcaagc   2340

cacgagggag agagttttcc tttgaggcct ggaatgccaa aatcacggac ctaaaacaga   2400

aagttgaaaa tctcttcaat gagaaatgtg gggaagctct tggccttaaa caagctgtga   2460

aggtgccgtt cgcgttattt gagtctttcc cggaagactt ttatgtggaa ggcttacctg   2520

agggtgtgcc attccgaaga ccatcgactt ttggcattcc gaggctggag aagatactca   2580

gaaacaaagc caaaattaag ttcatcatta aaaagcccga aatgtttgag acggcgatta   2640

aggagagcac ctcctctaag agccctccca gaaaaataaa ttcatcaccc aatgttaata   2700

ctactgcatc aggtgttgaa gaccttaaca tcattcaggt gacaattcca gatgatgata   2760

atgaaagact ctcgaaagtt gaaaaagcta gacagctaag agaacaagtg aatgacctct   2820

ttagtcggaa atttggtgaa gctattggta tgggttttcc tgtgaaagtt ccctacagga   2880

aaatcacaat taaccctggc tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca   2940

aagcccccag ctacctggaa atcagctcca tgagaaggat cttagactct gccgagttta   3000

tcaaattcac ggtcattagg taagtgagag tttcctgctt agtcacagga gcgaatctgg   3060

agctcatgag gctgactctt ctaaaatgca gccacaggta gtcatcgaat ccggcttcct   3120

atgctgtgca atcaacaaat caaaataact tgtgtcatca ttagaatgtc agatgtgctt   3180

ctacgaacta agctgactct tttaattctt tggcaaaggg ttggcaaact aggactgttt   3240

gccaaattca ggctgcctcc tatttttaga gtcttcctga aacacagcta cacccgtatt   3300

atccatggct gctttcctgt cacagtgagt aagtagctgg gactgagaag gcatggcctc   3360

caaagtctaa aatatttact ctctagcact ttgtagaaaa accttagcta ggcacagtgg   3420

ctaacgcctg taatcccagc attttgggag gccaaggcag gcagatcacc tgaggtcagg   3480

agttccagac cagcctggcc aacatggtga aatcccatct ctacaaaaat aaaacagtta   3540

gctgggcatg atggcgggtg cctgtaatcc cagctactcg ggaggctgag gcaggatagt   3600

cgcttgaacc caggaggtgg aggttgcaat gagccaagat catgccactg cactccagcc   3660

tggacgacag agtgagactc catcacaaga aaaaaagaac tttgtcaacc tctgtcttag   3720

ggcgccttgt cacaggcttc gggtcagacg gattcaacct tgcatcagcc atttgttagc   3780

caggtcactc tgttctttgt ctgtaaatga gattgatcgt tgttcccact gagagtgtca   3840

gctccttccc gtagagcagg catgatgatt gtactcacct ctgacaccat tgtgagtgcc   3900

acattccttc ccacgtcctt gtcactgtaa gagatgccca cctgagcacc aaccccaggt   3960

tatcttcccc tttgtcttcc agccccccag aaacagctac gactcaacct acccaatcat   4020

ttcatcatca gattgccact gtctctagtt caggtctctt gggactggca ctcagaaatc   4080

tcataataaa tcctcttgag gcttctcata cactcgtctt cttccaatct tctttccctc   4140

aaaatctcat attttggttc cacttcaccc accgtcattc tccatatcac tcccaggagt   4200

taggcaaaaa gccccttccg ttcttccgta tgttaaactt agaatcactc tgttccctgc   4260

tctgcgtttc tattttttgt ttttcctcca tttactagta gcttaacact ttctaacagt   4320

gttcttatta ttgatacgta tctatctctt ccataagctt ataaggtcac ggataatact   4380

tctcattgta gtacgtaaat gacgtgggct agatatgagt tgaataaaca gttatacctg   4440

taaattctta cagagtgaaa ataaattgtt atactttaca atttgtttct ctctttagac   4500

catttccagg acttgtgatt aataaccgtg agtattttgt gaagtgtttt gtttttgttt   4560

tttcctgggg tctgacgtgt gtgcgtgtga gtgtgtatac atgcttaacg tatatcacgt   4620

tacttcacct atgtcagtaa ccaggccaaa tacttgtttt agccctcagt aaaaacacca   4680

ggcacttcct agttgtaaaa ttattcaagc ttcttaactt cctatcctcg atgcacttaa   4740

tcataaaatg gtaataatag caccgatttt gggggagtcg ttccagtaga tggaaagcat   4800

ctggaacagg tgtcagcaag ctcctgccga cgtgtatgca taaagtttta ttgaaaccac   4860

catcgtgtcc atttgtttat ggcagaactg agagatggca gcagcaagtg tgtgcctgca   4920

aaacctaaaa tatttactaa ttggctctgc aagaaaagag tttgcatccc cctaacctag   4980

aacagtgtct agcctctagt atgtgtttag cctacagtat gtgctcagcg aatacaatct   5040

atatttatta ctgcttttat gactgttata attactgtgc ttggatttcg ttacaaagta   5100

agtcacaatg tgcctgcttc tgttagtatt tcagcacagt gcctggcaca catggggctc   5160

tcaaatattg ctgagcgagt gaacaaatgt cctttcaatt ccttaacgtt gatgtcattt   5220

tcaatagtat tttgagccaa acttaatttt gcgagtgtgt tttgttttct taactttatt   5280

attaaaaatg tataaaagtg aggccaggcg tggtggctca cgcctgtaat cccagcagtt   5340

tgggaggctg aggcaggcgg atcagttgag gttgggagtt ggagaccagc ccgtccaaca   5400

tggtgaaagc ctgtctctac taaaaataca aaaatcagct gggtgtggtg gcgcgtgcct   5460

gtaatcccag ctactcagga ggctgaggca ggagagttgc ttgaatccta gaggtggagg   5520

ttgcagtgag ctgagatcgt gccattgcac tccagcctgg gcaacaagag caaaactctg   5580

tcccaataaa taaataaata aaatgttctc ttttgttcct gttcttgtgc ggtagtgtgg   5640

tatagagttt tatggtaatt actgtgaatt agtgattctg agggacatat cagaactctg   5700

aggtttgttt ccttctcatc ttgagggaaa cagcaaatgt atgttaaaat gcttttccaa   5760

gggaacaaca catccttaca ttatttaaac caatctgctt cattttcaga gctggttgat   5820

cagagtgagt cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt   5880

ccagccacag aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac   5940

cccacgtggt agacctcttc cctcctaggg taaatcagct tctgtgtcag ggatgctgtg   6000

tggtgtccat ctgaaccccc tgcatacgcg tagctaatgt gatctcccca ctttcacata   6060

agatggtggc cctgccttca gggaatgtgg gagccaggtg ggagccttcc cggatattta   6120

agctagaaga ttctacaggg agattctcct tggatcaata tatgtctctc agtcaaagat   6180

gtaaaagcac ttttgcctta aaaagaatgt tctgtttcta aatagagtca acgttgtcct   6240

cctcattgga attcactatg agtcagaatc attagactga cttttttttt tccatagtaa   6300

tagtattttg cagagtctca cagagctgca gatcttttgt tcatcttgca gagttaacaa   6360

gtctgatcct gttagtccag atttcttaaa tttggccaag ttataatagg agcagtagct   6420

tgagacccga agtcaggaaa ctttgacaat ggattttttt ttttaatcca gagacttgta   6480

ctggaatttg ccttaccctg tcagctcatg gacttaaggt ttcatcccgc tttatgagtg   6540

cttctgaatc caagtcattg ttacctgaat ttgcaaatta agttgtgata ttcgtgactg   6600

ttaaattcct gtaattagat taacctcttt gcttgcttgt ttgttttctc tcctatttta   6660

gcttaaagta tcagtggttg agaagagctt ttcggacctg ttactacccc aagctgtgta   6720

atatacttgt ataacagaaa taccttctat acaaaccttt ttttctactt ttagatagaa   6780

atgtctactt tttcagcagt tctgtgaatt aaagagcaga gtgactgtgg gtctggaatg   6840

gctggtgtac ttgggaatgt actatcagga ttttacagca atgctgggaa atgacaggga   6900

aaatgacagg aatgaatctc accagatttt ttatgtactc agcagagcct tgagttacgg   6960

tgtttatttt ccaatcaagt gaagatatct cctacttctc ctactggaac atctcagctt   7020

ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa   7080

aaaatcattt aaatgatcct ttgttcacgg ctctccttaa tgactgagtg aacagttcct   7140

atctgtatat ttgactaaac cttttcctaa gctatctctc atggttccta tgttttttta   7200

tcataattaa aagcaaaacc atctggatca cctaacagtc agaggtcagt atctcagcgt   7260

gtgaattata gaggaaatac agagagaacc tcttccactt ttacttttcg tccaaataaa   7320

atgcatggtg taccagaagt tgaagatcgg gttgaggatt ggggctagct cgatgacact   7380

aaggccccaa catcgcggga cctgctgtgg cgcggattct taggaacgct gttctagccg   7440

gccccctctc caggggtcgc cgtggccggc attatttcct agttcttctt gtaaccctga   7500

ggtgccagcg cggggagtga ggaggggtca gggggctaag gatgcaacct ctgacgttct   7560

gcgccttcct aggagagtct tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa   7620

taccagctct acaagaagct aggctctgtg acggcatagt tttcagtagc tttatcacaa   7680

tattcacaat ggagaattat atgacatggt agcagaaata ggccctttta tgtgttgctt   7740

ctattttacc tcaaattgta gatatagggt aatcaataaa atccatccat gcctttcaca   7800

cactaagt                                                            7808


<210>  5015
<211>  921
<212>  PRT
<213>  Homo sapiens

<400>  5015

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
                565                 570                 575


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
            580                 585                 590


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
        595                 600                 605


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
    610                 615                 620


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
625                 630                 635                 640


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
                645                 650                 655


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
            660                 665                 670


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
        675                 680                 685


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
    690                 695                 700


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
705                 710                 715                 720


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
                725                 730                 735


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
            740                 745                 750


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
        755                 760                 765


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
    770                 775                 780


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
785                 790                 795                 800


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
                805                 810                 815


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
            820                 825                 830


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
        835                 840                 845


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
    850                 855                 860


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
865                 870                 875                 880


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
                885                 890                 895


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
            900                 905                 910


Glu Phe Ile Lys Phe Thr Val Ile Arg 
        915                 920


<210>  5016
<211>  4921
<212>  DNA
<213>  Homo sapiens

<400>  5016
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag    960

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1020

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1080

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1140

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1200

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1260

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1320

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1380

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1440

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1500

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1560

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1620

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1680

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1740

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1800

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1860

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1920

aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc   1980

ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt   2040

tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa   2100

taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg   2160

ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg   2220

ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga gggagagagt   2280

tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct   2340

tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt   2400

tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc   2460

gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa   2520

ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct   2580

ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg   2640

ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga   2700

aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg   2760

gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc   2820

ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc   2880

tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca   2940

ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt gagtcagaag   3000

gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc acagaaggta   3060

aaaggacctc ttccctccta gggtaaatca gcttctgtgt cagggatgct gtgtggtgtc   3120

catctgaacc ccctgcatac gcgtagctaa tgtgatctcc ccactttcac ataagatggt   3180

ggccctgcct tcagggaatg tgggagccag gtgggagcct tcccggatat ttaagctaga   3240

agattctaca gggagattct ccttggatca atatatgtct ctcagtcaaa gatgtaaaag   3300

cacttttgcc ttaaaaagaa tgttctgttt ctaaatagag tcaacgttgt cctcctcatt   3360

ggaattcact atgagtcaga atcattagac tgactttttt ttttccatag taatagtatt   3420

ttgcagagtc tcacagagct gcagatcttt tgttcatctt gcagagttaa caagtctgat   3480

cctgttagtc cagatttctt aaatttggcc aagttataat aggagcagta gcttgagacc   3540

cgaagtcagg aaactttgac aatggatttt tttttttaat ccagagactt gtactggaat   3600

ttgccttacc ctgtcagctc atggacttaa ggtttcatcc cgctttatga gtgcttctga   3660

atccaagtca ttgttacctg aatttgcaaa ttaagttgtg atattcgtga ctgttaaatt   3720

cctgtaatta gattaacctc tttgcttgct tgtttgtttt ctctcctatt ttagcttaaa   3780

gtatcagtgg ttgagaagag cttttcggac ctgttactac cccaagctgt gtaatatact   3840

tgtataacag aaataccttc tatacaaacc tttttttcta cttttagata gaaatgtcta   3900

ctttttcagc agttctgtga attaaagagc agagtgactg tgggtctgga atggctggtg   3960

tacttgggaa tgtactatca ggattttaca gcaatgctgg gaaatgacag ggaaaatgac   4020

aggaatgaat ctcaccagat tttttatgta ctcagcagag ccttgagtta cggtgtttat   4080

tttccaatca agtgaagata tctcctactt ctcctactgg aacatctcag cttctgcagt   4140

gaagaaaaat tcctgtgata gttcagttct ttagtttttc tatttgaaaa aaaaaaatca   4200

tttaaatgat cctttgttca cggctctcct taatgactga gtgaacagtt cctatctgta   4260

tatttgacta aaccttttcc taagctatct ctcatggttc ctatgttttt ttatcataat   4320

taaaagcaaa accatctgga tcacctaaca gtcagaggtc agtatctcag cgtgtgaatt   4380

atagaggaaa tacagagaga acctcttcca cttttacttt tcgtccaaat aaaatgcatg   4440

gtgtaccaga agttgaagat cgggttgagg attggggcta gctcgatgac actaaggccc   4500

caacatcgcg ggacctgctg tggcgcggat tcttaggaac gctgttctag ccggccccct   4560

ctccaggggt cgccgtggcc ggcattattt cctagttctt cttgtaaccc tgaggtgcca   4620

gcgcggggag tgaggagggg tcagggggct aaggatgcaa cctctgacgt tctgcgcctt   4680

cctaggagag tcttacatgt gttgagattt cacaagcaat gcgagttgta aaataccagc   4740

tctacaagaa gctaggctct gtgacggcat agttttcagt agctttatca caatattcac   4800

aatggagaat tatatgacat ggtagcagaa ataggccctt ttatgtgttg cttctatttt   4860

acctcaaatt gtagatatag ggtaatcaat aaaatccatc catgcctttc acacactaag   4920

t                                                                   4921


<210>  5017
<211>  942
<212>  PRT
<213>  Homo sapiens

<400>  5017

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr 
                565                 570                 575


Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys 
            580                 585                 590


Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro 
        595                 600                 605


Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys 
    610                 615                 620


Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val 
625                 630                 635                 640


Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg 
                645                 650                 655


Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly 
            660                 665                 670


Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys 
        675                 680                 685


Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly 
    690                 695                 700


Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro 
705                 710                 715                 720


Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg 
                725                 730                 735


Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys 
            740                 745                 750


Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala 
        755                 760                 765


Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser 
    770                 775                 780


Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile 
785                 790                 795                 800


Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val 
                805                 810                 815


Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg 
            820                 825                 830


Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr 
        835                 840                 845


Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro 
    850                 855                 860


Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met 
865                 870                 875                 880


Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
                885                 890                 895


Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu 
            900                 905                 910


Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu 
        915                 920                 925


Val Pro Ala Thr Glu Gly Lys Arg Thr Ser Ser Leu Leu Gly 
    930                 935                 940


<210>  5018
<211>  7047
<212>  DNA
<213>  Homo sapiens

<400>  5018
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1080

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1140

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1200

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1260

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1320

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1380

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1440

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1500

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1560

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1620

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1680

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1740

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1800

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1860

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   1920

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   1980

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2040

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2100

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2160

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2220

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2280

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2340

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2400

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2460

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2520

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2580

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2640

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2700

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2760

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2820

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   2880

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   2940

cggtcattag gtaagtgaga gtttcctgct tagtcacagg agcgaatctg gagctcatga   3000

ggctgactct tctaaaatgc agccacaggt agtcatcgaa tccggcttcc tatgctgtgc   3060

aatcaacaaa tcaaaataac ttgtgtcatc attagaatgt cagatgtgct tctacgaact   3120

aagctgactc ttttaattct ttggcaaagg gttggcaaac taggactgtt tgccaaattc   3180

aggctgcctc ctatttttag agtcttcctg aaacacagct acacccgtat tatccatggc   3240

tgctttcctg tcacagtgag taagtagctg ggactgagaa ggcatggcct ccaaagtcta   3300

aaatatttac tctctagcac tttgtagaaa aaccttagct aggcacagtg gctaacgcct   3360

gtaatcccag cattttggga ggccaaggca ggcagatcac ctgaggtcag gagttccaga   3420

ccagcctggc caacatggtg aaatcccatc tctacaaaaa taaaacagtt agctgggcat   3480

gatggcgggt gcctgtaatc ccagctactc gggaggctga ggcaggatag tcgcttgaac   3540

ccaggaggtg gaggttgcaa tgagccaaga tcatgccact gcactccagc ctggacgaca   3600

gagtgagact ccatcacaag aaaaaaagaa ctttgtcaac ctctgtctta gggcgccttg   3660

tcacaggctt cgggtcagac ggattcaacc ttgcatcagc catttgttag ccaggtcact   3720

ctgttctttg tctgtaaatg agattgatcg ttgttcccac tgagagtgtc agctccttcc   3780

cgtagagcag gcatgatgat tgtactcacc tctgacacca ttgtgagtgc cacattcctt   3840

cccacgtcct tgtcactgta agagatgccc acctgagcac caaccccagg ttatcttccc   3900

ctttgtcttc cagcccccca gaaacagcta cgactcaacc tacccaatca tttcatcatc   3960

agattgccac tgtctctagt tcaggtctct tgggactggc actcagaaat ctcataataa   4020

atcctcttga ggcttctcat acactcgtct tcttccaatc ttctttccct caaaatctca   4080

tattttggtt ccacttcacc caccgtcatt ctccatatca ctcccaggag ttaggcaaaa   4140

agccccttcc gttcttccgt atgttaaact tagaatcact ctgttccctg ctctgcgttt   4200

ctattttttg tttttcctcc atttactagt agcttaacac tttctaacag tgttcttatt   4260

attgatacgt atctatctct tccataagct tataaggtca cggataatac ttctcattgt   4320

agtacgtaaa tgacgtgggc tagatatgag ttgaataaac agttatacct gtaaattctt   4380

acagagtgaa aataaattgt tatactttac aatttgtttc tctctttaga ccatttccag   4440

gacttgtgat taataaccgt gagtattttg tgaagtgttt tgtttttgtt ttttcctggg   4500

gtctgacgtg tgtgcgtgtg agtgtgtata catgcttaac gtatatcacg ttacttcacc   4560

tatgtcagta accaggccaa atacttgttt tagccctcag taaaaacacc aggcacttcc   4620

tagttgtaaa attattcaag cttcttaact tcctatcctc gatgcactta atcataaaat   4680

ggtaataata gcaccgattt tgggggagtc gttccagtag atggaaagca tctggaacag   4740

gtgtcagcaa gctcctgccg acgtgtatgc ataaagtttt attgaaacca ccatcgtgtc   4800

catttgttta tggcagaact gagagatggc agcagcaagt gtgtgcctgc aaaacctaaa   4860

atatttacta attggctctg caagaaaaga gtttgcatcc ccctaaccta gaacagtgtc   4920

tagcctctag tatgtgttta gcctacagta tgtgctcagc gaatacaatc tatatttatt   4980

actgctttta tgactgttat aattactgtg cttggatttc gttacaaagt aagtcacaat   5040

gtgcctgctt ctgttagtat ttcagcacag tgcctggcac acatggggct ctcaaatatt   5100

gctgagcgag tgaacaaatg tcctttcaat tccttaacgt tgatgtcatt ttcaatagta   5160

ttttgagcca aacttaattt tgcgagtgtg ttttgttttc ttaactttat tattaaaaat   5220

gtataaaagt gaggccaggc gtggtggctc acgcctgtaa tcccagcagt ttgggaggct   5280

gaggcaggcg gatcagttga ggttgggagt tggagaccag cccgtccaac atggtgaaag   5340

cctgtctcta ctaaaaatac aaaaatcagc tgggtgtggt ggcgcgtgcc tgtaatccca   5400

gctactcagg aggctgaggc aggagagttg cttgaatcct agaggtggag gttgcagtga   5460

gctgagatcg tgccattgca ctccagcctg ggcaacaaga gcaaaactct gtcccaataa   5520

ataaataaat aaaatgttct cttttgttcc tgttcttgtg cggtagtgtg gtatagagtt   5580

ttatggtaat tactgtgaat tagtgattct gagggacata tcagaactct gaggtttgtt   5640

tccttctcat cttgagggaa acagcaaatg tatgttaaaa tgcttttcca agggaacaac   5700

acatccttac attatttaaa ccaatctgct tcattttcag agctggttga tcagagtgag   5760

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   5820

gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga ccccacgtgg   5880

tagacctctt ccctcctagg cttaaagtat cagtggttga gaagagcttt tcggacctgt   5940

tactacccca agctgtgtaa tatacttgta taacagaaat accttctata caaacctttt   6000

tttctacttt tagatagaaa tgtctacttt ttcagcagtt ctgtgaatta aagagcagag   6060

tgactgtggg tctggaatgg ctggtgtact tgggaatgta ctatcaggat tttacagcaa   6120

tgctgggaaa tgacagggaa aatgacagga atgaatctca ccagattttt tatgtactca   6180

gcagagcctt gagttacggt gtttattttc caatcaagtg aagatatctc ctacttctcc   6240

tactggaaca tctcagcttc tgcagtgaag aaaaattcct gtgatagttc agttctttag   6300

tttttctatt tgaaaaaaaa aaatcattta aatgatcctt tgttcacggc tctccttaat   6360

gactgagtga acagttccta tctgtatatt tgactaaacc ttttcctaag ctatctctca   6420

tggttcctat gtttttttat cataattaaa agcaaaacca tctggatcac ctaacagtca   6480

gaggtcagta tctcagcgtg tgaattatag aggaaataca gagagaacct cttccacttt   6540

tacttttcgt ccaaataaaa tgcatggtgt accagaagtt gaagatcggg ttgaggattg   6600

gggctagctc gatgacacta aggccccaac atcgcgggac ctgctgtggc gcggattctt   6660

aggaacgctg ttctagccgg ccccctctcc aggggtcgcc gtggccggca ttatttccta   6720

gttcttcttg taaccctgag gtgccagcgc ggggagtgag gaggggtcag ggggctaagg   6780

atgcaacctc tgacgttctg cgccttccta ggagagtctt acatgtgttg agatttcaca   6840

agcaatgcga gttgtaaaat accagctcta caagaagcta ggctctgtga cggcatagtt   6900

ttcagtagct ttatcacaat attcacaatg gagaattata tgacatggta gcagaaatag   6960

gcccttttat gtgttgcttc tattttacct caaattgtag atatagggta atcaataaaa   7020

tccatccatg cctttcacac actaagt                                       7047


<210>  5019
<211>  898
<212>  PRT
<213>  Homo sapiens

<400>  5019

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly 
    530                 535                 540


Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro 
545                 550                 555                 560


Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser 
                565                 570                 575


Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser 
            580                 585                 590


Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr 
        595                 600                 605


Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser 
    610                 615                 620


Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile 
625                 630                 635                 640


Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala 
                645                 650                 655


Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro 
            660                 665                 670


Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp 
        675                 680                 685


Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala 
    690                 695                 700


Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser 
705                 710                 715                 720


Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe 
                725                 730                 735


Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg 
            740                 745                 750


Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu 
        755                 760                 765


Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile 
    770                 775                 780


Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu 
785                 790                 795                 800


Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser 
                805                 810                 815


Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe 
            820                 825                 830


Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val 
        835                 840                 845


Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly 
    850                 855                 860


Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser 
865                 870                 875                 880


Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val 
                885                 890                 895


Ile Arg 



<210>  5020
<211>  4186
<212>  DNA
<213>  Homo sapiens

<400>  5020
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1080

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1140

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1200

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1260

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1320

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1380

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1440

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1500

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1560

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1620

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1680

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1740

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1800

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1860

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1920

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   1980

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2040

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2100

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2160

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2220

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2280

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2340

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2400

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2460

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2520

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2580

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2640

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2700

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2760

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2820

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   2880

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   2940

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3000

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3060

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3120

ttcacggtca ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt   3180

gagtcagaag gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc   3240

acagaagaaa taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg   3300

tggtagacct cttccctcct aggagccttg agttacggtg tttattttcc aatcaagtga   3360

agatatctcc tacttctcct actggaacat ctcagcttct gcagtgaaga aaaattcctg   3420

tgatagttca gttctttagt ttttctattt gaaaaaaaaa aatcatttaa atgatccttt   3480

gttcacggct ctccttaatg actgagtgaa cagttcctat ctgtatattt gactaaacct   3540

tttcctaagc tatctctcat ggttcctatg tttttttatc ataattaaaa gcaaaaccat   3600

ctggatcacc taacagtcag aggtcagtat ctcagcgtgt gaattataga ggaaatacag   3660

agagaacctc ttccactttt acttttcgtc caaataaaat gcatggtgta ccagaagttg   3720

aagatcgggt tgaggattgg ggctagctcg atgacactaa ggccccaaca tcgcgggacc   3780

tgctgtggcg cggattctta ggaacgctgt tctagccggc cccctctcca ggggtcgccg   3840

tggccggcat tatttcctag ttcttcttgt aaccctgagg tgccagcgcg gggagtgagg   3900

aggggtcagg gggctaagga tgcaacctct gacgttctgc gccttcctag gagagtctta   3960

catgtgttga gatttcacaa gcaatgcgag ttgtaaaata ccagctctac aagaagctag   4020

gctctgtgac ggcatagttt tcagtagctt tatcacaata ttcacaatgg agaattatat   4080

gacatggtag cagaaatagg cccttttatg tgttgcttct attttacctc aaattgtaga   4140

tatagggtaa tcaataaaat ccatccatgc ctttcacaca ctaagt                  4186


<210>  5021
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  5021

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala 



<210>  5022
<211>  4418
<212>  DNA
<213>  Homo sapiens

<400>  5022
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040

taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2100

ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2160

ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2220

ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2280

ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2340

atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2400

agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2460

agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2520

tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2580

ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2640

tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2700

ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2760

atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2820

ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2880

tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   2940

ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   3000

tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3060

ttatcaaatt cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg   3120

atcagagtga gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag   3180

ttccagccac agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag   3240

accccacgtg gtagacctct tccctcctag gcttaaagta tcagtggttg agaagagctt   3300

ttcggacctg ttactacccc aagctgtgta atatacttgt ataacagaaa taccttctat   3360

acaaaccttt ttttctactt ttagatagaa atgtctactt tttcagcagt tctgtgaatt   3420

aaagagcaga gtgactgtgg gtctggaatg gctggtgtac ttgggaatgt actatcagga   3480

ttttacagca atgctgggaa atgacaggga aaatgacagg aatgaatctc accagatttt   3540

ttatgtactc agcagagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct   3600

cctacttctc ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt   3660

cagttcttta gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg   3720

ctctccttaa tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa   3780

gctatctctc atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca   3840

cctaacagtc agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc   3900

tcttccactt ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg   3960

gttgaggatt ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg   4020

cgcggattct taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc   4080

attatttcct agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca   4140

gggggctaag gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt   4200

gagatttcac aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg   4260

acggcatagt tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt   4320

agcagaaata ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt   4380

aatcaataaa atccatccat gcctttcaca cactaagt                           4418


<210>  5023
<211>  998
<212>  PRT
<213>  Homo sapiens

<400>  5023

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr 
        595                 600                 605


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe 
    610                 615                 620


Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys 
625                 630                 635                 640


Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly 
                645                 650                 655


Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro 
            660                 665                 670


Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val 
        675                 680                 685


Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro 
    690                 695                 700


Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu 
705                 710                 715                 720


Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys 
                725                 730                 735


Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys 
            740                 745                 750


Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp 
        755                 760                 765


Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser 
    770                 775                 780


Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys 
785                 790                 795                 800


Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys 
                805                 810                 815


Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro 
            820                 825                 830


Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln 
        835                 840                 845


Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys 
    850                 855                 860


Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe 
865                 870                 875                 880


Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys 
                885                 890                 895


Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly 
            900                 905                 910


Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg 
        915                 920                 925


Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe 
    930                 935                 940


Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu 
945                 950                 955                 960


Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro 
                965                 970                 975


Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln 
            980                 985                 990


Glu Pro Asp Pro Thr Trp 
        995


<210>  5024
<211>  3803
<212>  DNA
<213>  Homo sapiens

<400>  5024
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1980

catatcctgt gtttgaatca aacccggagt tcttgtatgt ggaaggcttg ccagagggga   2040

ttcccttccg aagccctacc tggtttggaa ttccacgact tgaaaggatc gtccgcggga   2100

gtaataaaat caagttcgtt gttaaaaaac ctgaactagt tatttcctac ttgcctcctg   2160

ggatggctag taaaataaac actaaagctt tgcagtcccc caaaagacca cgaagtcctg   2220

ggagtaattc aaaggttcct gaaattgagg tcaccgtgga aggccctaat aacaacaatc   2280

ctcaaacctc agctgttcga accccgaccc agactaacgg ttctaacgtt cccttcaagc   2340

cacgagggag agagttttcc tttgaggcct ggaatgccaa aatcacggac ctaaaacaga   2400

aagttgaaaa tctcttcaat gagaaatgtg gggaagctct tggccttaaa caagctgtga   2460

aggtgccgtt cgcgttattt gagtctttcc cggaagactt ttatgtggaa ggcttacctg   2520

agggtgtgcc attccgaaga ccatcgactt ttggcattcc gaggctggag aagatactca   2580

gaaacaaagc caaaattaag ttcatcatta aaaagcccga aatgtttgag acggcgatta   2640

aggagagcac ctcctctaag agccctccca gaaaaataaa ttcatcaccc aatgttaata   2700

ctactgcatc aggtgttgaa gaccttaaca tcattcaggt gacaattcca gatgatgata   2760

atgaaagact ctcgaaagtt gaaaaagcta gacagctaag agaacaagtg aatgacctct   2820

ttagtcggaa atttggtgaa gctattggta tgggttttcc tgtgaaagtt ccctacagga   2880

aaatcacaat taaccctggc tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca   2940

aagcccccag ctacctggaa atcagctcca tgagaaggat cttagactct gccgagttta   3000

tcaaattcac ggtcattaga ccatttccag gacttgtgat taataaccag ctggttgatc   3060

agagtgagtc agaaggcccc gtgatacaag aatcagctga accaagccag ttggaagttc   3120

cagccacaga agaaataaaa gagactgatg gaagctctca gatcaagcaa gaaccagacc   3180

ccacgtggta gacctcttcc ctcctaggca aaaccatctg gatcacctaa cagtcagagg   3240

tcagtatctc agcgtgtgaa ttatagagga aatacagaga gaacctcttc cacttttact   3300

tttcgtccaa ataaaatgca tggtgtacca gaagttgaag atcgggttga ggattggggc   3360

tagctcgatg acactaaggc cccaacatcg cgggacctgc tgtggcgcgg attcttagga   3420

acgctgttct agccggcccc ctctccaggg gtcgccgtgg ccggcattat ttcctagttc   3480

ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc   3540

aacctctgac gttctgcgcc ttcctaggag agtcttacat gtgttgagat ttcacaagca   3600

atgcgagttg taaaatacca gctctacaag aagctaggct ctgtgacggc atagttttca   3660

gtagctttat cacaatattc acaatggaga attatatgac atggtagcag aaataggccc   3720

ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat agggtaatca ataaaatcca   3780

tccatgcctt tcacacacta agt                                           3803


<210>  5025
<211>  977
<212>  PRT
<213>  Homo sapiens

<400>  5025

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
                565                 570                 575


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
            580                 585                 590


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
        595                 600                 605


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
    610                 615                 620


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
625                 630                 635                 640


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
                645                 650                 655


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
            660                 665                 670


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
        675                 680                 685


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
    690                 695                 700


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
705                 710                 715                 720


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
                725                 730                 735


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
            740                 745                 750


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
        755                 760                 765


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
    770                 775                 780


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
785                 790                 795                 800


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
                805                 810                 815


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
            820                 825                 830


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
        835                 840                 845


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
    850                 855                 860


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
865                 870                 875                 880


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
                885                 890                 895


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
            900                 905                 910


Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile 
        915                 920                 925


Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln 
    930                 935                 940


Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile 
945                 950                 955                 960


Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr 
                965                 970                 975


Trp 



<210>  5026
<211>  4164
<212>  DNA
<213>  Homo sapiens

<400>  5026
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag    960

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1020

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1080

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1140

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1200

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1260

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1320

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1380

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1440

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1500

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1560

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1620

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1680

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1740

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1800

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1860

tgaaatttgc ttagatttgt tgacagcggt ttcctggagt gctgtcttga gaacgattct   1920

gaggaggctc agcaagaaag agtgtttcag ttgattgggt gtgtctgtca tggagaagga   1980

actcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac   2040

ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg   2100

tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2160

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2220

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2280

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2340

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2400

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2460

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2520

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2580

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2640

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2700

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2760

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2820

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2880

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   2940

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3000

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca   3060

tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg   3120

atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag   3180

actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc   3240

ctaggcttaa agtatcagtg gttgagaaga gcttttcgga cctgttacta ccccaagctg   3300

tagccttgag ttacggtgtt tattttccaa tcaagtgaag atatctccta cttctcctac   3360

tggaacatct cagcttctgc agtgaagaaa aattcctgtg atagttcagt tctttagttt   3420

ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt tcacggctct ccttaatgac   3480

tgagtgaaca gttcctatct gtatatttga ctaaaccttt tcctaagcta tctctcatgg   3540

ttcctatgtt tttttatcat aattaaaagc aaaaccatct ggatcaccta acagtcagag   3600

gtcagtatct cagcgtgtga attatagagg aaatacagag agaacctctt ccacttttac   3660

ttttcgtcca aataaaatgc atggtgtacc agaagttgaa gatcgggttg aggattgggg   3720

ctagctcgat gacactaagg ccccaacatc gcgggacctg ctgtggcgcg gattcttagg   3780

aacgctgttc tagccggccc cctctccagg ggtcgccgtg gccggcatta tttcctagtt   3840

cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg gctaaggatg   3900

caacctctga cgttctgcgc cttcctagga gagtcttaca tgtgttgaga tttcacaagc   3960

aatgcgagtt gtaaaatacc agctctacaa gaagctaggc tctgtgacgg catagttttc   4020

agtagcttta tcacaatatt cacaatggag aattatatga catggtagca gaaataggcc   4080

cttttatgtg ttgcttctat tttacctcaa attgtagata tagggtaatc aataaaatcc   4140

atccatgcct ttcacacact aagt                                          4164


<210>  5027
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  5027

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535


<210>  5028
<211>  4123
<212>  DNA
<213>  Homo sapiens

<400>  5028
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1080

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1140

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1200

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1260

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1320

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1380

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1440

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1500

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1560

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1620

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1680

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1740

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1800

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1860

aagagatttt taatttgaaa tttgcttaga tttgttgaca gcggtttcct ggagtgctgt   1920

cttgagaacg attctgagga ggctcagcaa gaaagagtgt ttcagttgat tgggtgtgtc   1980

tgtcatggag aaggaactca agctcttgga ctcaccgagg cagtaaaagt accatatcct   2040

gtgtttgaat caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc   2100

cgaagcccta cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa   2160

atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct   2220

agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat   2280

tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc   2340

tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg   2400

agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa   2460

aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg   2520

ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg   2580

ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa   2640

gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc   2700

acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca   2760

tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga   2820

ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg   2880

aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca   2940

attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt caaagccccc   3000

agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc   3060

acggtcatta gaccatttcc aggacttgtg attaataacc agctggttga tcagagtgag   3120

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   3180

gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga ccccacgtgg   3240

tagacctctt ccctcctagg agccttgagt tacggtgttt attttccaat caagtgaaga   3300

tatctcctac ttctcctact ggaacatctc agcttctgca gtgaagaaaa attcctgtga   3360

tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat catttaaatg atcctttgtt   3420

cacggctctc cttaatgact gagtgaacag ttcctatctg tatatttgac taaacctttt   3480

cctaagctat ctctcatggt tcctatgttt ttttatcata attaaaagca aaaccatctg   3540

gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa ttatagagga aatacagaga   3600

gaacctcttc cacttttact tttcgtccaa ataaaatgca tggtgtacca gaagttgaag   3660

atcgggttga ggattggggc tagctcgatg acactaaggc cccaacatcg cgggacctgc   3720

tgtggcgcgg attcttagga acgctgttct agccggcccc ctctccaggg gtcgccgtgg   3780

ccggcattat ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg   3840

ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc ttcctaggag agtcttacat   3900

gtgttgagat ttcacaagca atgcgagttg taaaatacca gctctacaag aagctaggct   3960

ctgtgacggc atagttttca gtagctttat cacaatattc acaatggaga attatatgac   4020

atggtagcag aaataggccc ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat   4080

agggtaatca ataaaatcca tccatgcctt tcacacacta agt                     4123


<210>  5029
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  5029

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  5030
<211>  7748
<212>  DNA
<213>  Homo sapiens

<400>  5030
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1080

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1140

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1200

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1260

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1320

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1380

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1440

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1500

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1560

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1620

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1680

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1740

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1800

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1860

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1920

catatcctgt gtttgaatca aacccggagt tcttgtatgt ggaaggcttg ccagagggga   1980

ttcccttccg aagccctacc tggtttggaa ttccacgact tgaaaggatc gtccgcggga   2040

gtaataaaat caagttcgtt gttaaaaaac ctgaactagt tatttcctac ttgcctcctg   2100

ggatggctag taaaataaac actaaagctt tgcagtcccc caaaagacca cgaagtcctg   2160

ggagtaattc aaaggttcct gaaattgagg tcaccgtgga aggccctaat aacaacaatc   2220

ctcaaacctc agctgttcga accccgaccc agactaacgg ttctaacgtt cccttcaagc   2280

cacgagggag agagttttcc tttgaggcct ggaatgccaa aatcacggac ctaaaacaga   2340

aagttgaaaa tctcttcaat gagaaatgtg gggaagctct tggccttaaa caagctgtga   2400

aggtgccgtt cgcgttattt gagtctttcc cggaagactt ttatgtggaa ggcttacctg   2460

agggtgtgcc attccgaaga ccatcgactt ttggcattcc gaggctggag aagatactca   2520

gaaacaaagc caaaattaag ttcatcatta aaaagcccga aatgtttgag acggcgatta   2580

aggagagcac ctcctctaag agccctccca gaaaaataaa ttcatcaccc aatgttaata   2640

ctactgcatc aggtgttgaa gaccttaaca tcattcaggt gacaattcca gatgatgata   2700

atgaaagact ctcgaaagtt gaaaaagcta gacagctaag agaacaagtg aatgacctct   2760

ttagtcggaa atttggtgaa gctattggta tgggttttcc tgtgaaagtt ccctacagga   2820

aaatcacaat taaccctggc tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca   2880

aagcccccag ctacctggaa atcagctcca tgagaaggat cttagactct gccgagttta   2940

tcaaattcac ggtcattagg taagtgagag tttcctgctt agtcacagga gcgaatctgg   3000

agctcatgag gctgactctt ctaaaatgca gccacaggta gtcatcgaat ccggcttcct   3060

atgctgtgca atcaacaaat caaaataact tgtgtcatca ttagaatgtc agatgtgctt   3120

ctacgaacta agctgactct tttaattctt tggcaaaggg ttggcaaact aggactgttt   3180

gccaaattca ggctgcctcc tatttttaga gtcttcctga aacacagcta cacccgtatt   3240

atccatggct gctttcctgt cacagtgagt aagtagctgg gactgagaag gcatggcctc   3300

caaagtctaa aatatttact ctctagcact ttgtagaaaa accttagcta ggcacagtgg   3360

ctaacgcctg taatcccagc attttgggag gccaaggcag gcagatcacc tgaggtcagg   3420

agttccagac cagcctggcc aacatggtga aatcccatct ctacaaaaat aaaacagtta   3480

gctgggcatg atggcgggtg cctgtaatcc cagctactcg ggaggctgag gcaggatagt   3540

cgcttgaacc caggaggtgg aggttgcaat gagccaagat catgccactg cactccagcc   3600

tggacgacag agtgagactc catcacaaga aaaaaagaac tttgtcaacc tctgtcttag   3660

ggcgccttgt cacaggcttc gggtcagacg gattcaacct tgcatcagcc atttgttagc   3720

caggtcactc tgttctttgt ctgtaaatga gattgatcgt tgttcccact gagagtgtca   3780

gctccttccc gtagagcagg catgatgatt gtactcacct ctgacaccat tgtgagtgcc   3840

acattccttc ccacgtcctt gtcactgtaa gagatgccca cctgagcacc aaccccaggt   3900

tatcttcccc tttgtcttcc agccccccag aaacagctac gactcaacct acccaatcat   3960

ttcatcatca gattgccact gtctctagtt caggtctctt gggactggca ctcagaaatc   4020

tcataataaa tcctcttgag gcttctcata cactcgtctt cttccaatct tctttccctc   4080

aaaatctcat attttggttc cacttcaccc accgtcattc tccatatcac tcccaggagt   4140

taggcaaaaa gccccttccg ttcttccgta tgttaaactt agaatcactc tgttccctgc   4200

tctgcgtttc tattttttgt ttttcctcca tttactagta gcttaacact ttctaacagt   4260

gttcttatta ttgatacgta tctatctctt ccataagctt ataaggtcac ggataatact   4320

tctcattgta gtacgtaaat gacgtgggct agatatgagt tgaataaaca gttatacctg   4380

taaattctta cagagtgaaa ataaattgtt atactttaca atttgtttct ctctttagac   4440

catttccagg acttgtgatt aataaccgtg agtattttgt gaagtgtttt gtttttgttt   4500

tttcctgggg tctgacgtgt gtgcgtgtga gtgtgtatac atgcttaacg tatatcacgt   4560

tacttcacct atgtcagtaa ccaggccaaa tacttgtttt agccctcagt aaaaacacca   4620

ggcacttcct agttgtaaaa ttattcaagc ttcttaactt cctatcctcg atgcacttaa   4680

tcataaaatg gtaataatag caccgatttt gggggagtcg ttccagtaga tggaaagcat   4740

ctggaacagg tgtcagcaag ctcctgccga cgtgtatgca taaagtttta ttgaaaccac   4800

catcgtgtcc atttgtttat ggcagaactg agagatggca gcagcaagtg tgtgcctgca   4860

aaacctaaaa tatttactaa ttggctctgc aagaaaagag tttgcatccc cctaacctag   4920

aacagtgtct agcctctagt atgtgtttag cctacagtat gtgctcagcg aatacaatct   4980

atatttatta ctgcttttat gactgttata attactgtgc ttggatttcg ttacaaagta   5040

agtcacaatg tgcctgcttc tgttagtatt tcagcacagt gcctggcaca catggggctc   5100

tcaaatattg ctgagcgagt gaacaaatgt cctttcaatt ccttaacgtt gatgtcattt   5160

tcaatagtat tttgagccaa acttaatttt gcgagtgtgt tttgttttct taactttatt   5220

attaaaaatg tataaaagtg aggccaggcg tggtggctca cgcctgtaat cccagcagtt   5280

tgggaggctg aggcaggcgg atcagttgag gttgggagtt ggagaccagc ccgtccaaca   5340

tggtgaaagc ctgtctctac taaaaataca aaaatcagct gggtgtggtg gcgcgtgcct   5400

gtaatcccag ctactcagga ggctgaggca ggagagttgc ttgaatccta gaggtggagg   5460

ttgcagtgag ctgagatcgt gccattgcac tccagcctgg gcaacaagag caaaactctg   5520

tcccaataaa taaataaata aaatgttctc ttttgttcct gttcttgtgc ggtagtgtgg   5580

tatagagttt tatggtaatt actgtgaatt agtgattctg agggacatat cagaactctg   5640

aggtttgttt ccttctcatc ttgagggaaa cagcaaatgt atgttaaaat gcttttccaa   5700

gggaacaaca catccttaca ttatttaaac caatctgctt cattttcaga gctggttgat   5760

cagagtgagt cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt   5820

ccagccacag aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac   5880

cccacgtggt agacctcttc cctcctaggg taaatcagct tctgtgtcag ggatgctgtg   5940

tggtgtccat ctgaaccccc tgcatacgcg tagctaatgt gatctcccca ctttcacata   6000

agatggtggc cctgccttca gggaatgtgg gagccaggtg ggagccttcc cggatattta   6060

agctagaaga ttctacaggg agattctcct tggatcaata tatgtctctc agtcaaagat   6120

gtaaaagcac ttttgcctta aaaagaatgt tctgtttcta aatagagtca acgttgtcct   6180

cctcattgga attcactatg agtcagaatc attagactga cttttttttt tccatagtaa   6240

tagtattttg cagagtctca cagagctgca gatcttttgt tcatcttgca gagttaacaa   6300

gtctgatcct gttagtccag atttcttaaa tttggccaag ttataatagg agcagtagct   6360

tgagacccga agtcaggaaa ctttgacaat ggattttttt ttttaatcca gagacttgta   6420

ctggaatttg ccttaccctg tcagctcatg gacttaaggt ttcatcccgc tttatgagtg   6480

cttctgaatc caagtcattg ttacctgaat ttgcaaatta agttgtgata ttcgtgactg   6540

ttaaattcct gtaattagat taacctcttt gcttgcttgt ttgttttctc tcctatttta   6600

gcttaaagta tcagtggttg agaagagctt ttcggacctg ttactacccc aagctgtgta   6660

atatacttgt ataacagaaa taccttctat acaaaccttt ttttctactt ttagatagaa   6720

atgtctactt tttcagcagt tctgtgaatt aaagagcaga gtgactgtgg gtctggaatg   6780

gctggtgtac ttgggaatgt actatcagga ttttacagca atgctgggaa atgacaggga   6840

aaatgacagg aatgaatctc accagatttt ttatgtactc agcagagcct tgagttacgg   6900

tgtttatttt ccaatcaagt gaagatatct cctacttctc ctactggaac atctcagctt   6960

ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa   7020

aaaatcattt aaatgatcct ttgttcacgg ctctccttaa tgactgagtg aacagttcct   7080

atctgtatat ttgactaaac cttttcctaa gctatctctc atggttccta tgttttttta   7140

tcataattaa aagcaaaacc atctggatca cctaacagtc agaggtcagt atctcagcgt   7200

gtgaattata gaggaaatac agagagaacc tcttccactt ttacttttcg tccaaataaa   7260

atgcatggtg taccagaagt tgaagatcgg gttgaggatt ggggctagct cgatgacact   7320

aaggccccaa catcgcggga cctgctgtgg cgcggattct taggaacgct gttctagccg   7380

gccccctctc caggggtcgc cgtggccggc attatttcct agttcttctt gtaaccctga   7440

ggtgccagcg cggggagtga ggaggggtca gggggctaag gatgcaacct ctgacgttct   7500

gcgccttcct aggagagtct tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa   7560

taccagctct acaagaagct aggctctgtg acggcatagt tttcagtagc tttatcacaa   7620

tattcacaat ggagaattat atgacatggt agcagaaata ggccctttta tgtgttgctt   7680

ctattttacc tcaaattgta gatatagggt aatcaataaa atccatccat gcctttcaca   7740

cactaagt                                                            7748


<210>  5031
<211>  901
<212>  PRT
<213>  Homo sapiens

<400>  5031

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
                565                 570                 575


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
            580                 585                 590


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
        595                 600                 605


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
    610                 615                 620


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
625                 630                 635                 640


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
                645                 650                 655


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
            660                 665                 670


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
        675                 680                 685


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
    690                 695                 700


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
705                 710                 715                 720


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
                725                 730                 735


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
            740                 745                 750


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
        755                 760                 765


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
    770                 775                 780


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
785                 790                 795                 800


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
                805                 810                 815


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
            820                 825                 830


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
        835                 840                 845


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
    850                 855                 860


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
865                 870                 875                 880


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
                885                 890                 895


Phe Thr Val Ile Arg 
            900


<210>  5032
<211>  7860
<212>  DNA
<213>  Homo sapiens

<400>  5032
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1080

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1140

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1200

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1260

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1320

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1380

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1440

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1500

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1560

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1620

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1680

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1740

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1800

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1860

aagagatttt taatttgaaa tttgcttaga tttgttgaca gcggtttcct ggagtgctgt   1920

cttgagaacg attctgagga ggctcagcaa gaaagagtgt ttcagttgat tgggtgtgtc   1980

tgtcatggag aaggaactca agctcttgga ctcaccgagg cagtaaaagt accatatcct   2040

gtgtttgaat caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc   2100

cgaagcccta cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa   2160

atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct   2220

agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat   2280

tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc   2340

tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg   2400

agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa   2460

aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg   2520

ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg   2580

ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa   2640

gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc   2700

acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca   2760

tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga   2820

ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg   2880

aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca   2940

attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt caaagccccc   3000

agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc   3060

acggtcatta ggtaagtgag agtttcctgc ttagtcacag gagcgaatct ggagctcatg   3120

aggctgactc ttctaaaatg cagccacagg tagtcatcga atccggcttc ctatgctgtg   3180

caatcaacaa atcaaaataa cttgtgtcat cattagaatg tcagatgtgc ttctacgaac   3240

taagctgact cttttaattc tttggcaaag ggttggcaaa ctaggactgt ttgccaaatt   3300

caggctgcct cctattttta gagtcttcct gaaacacagc tacacccgta ttatccatgg   3360

ctgctttcct gtcacagtga gtaagtagct gggactgaga aggcatggcc tccaaagtct   3420

aaaatattta ctctctagca ctttgtagaa aaaccttagc taggcacagt ggctaacgcc   3480

tgtaatccca gcattttggg aggccaaggc aggcagatca cctgaggtca ggagttccag   3540

accagcctgg ccaacatggt gaaatcccat ctctacaaaa ataaaacagt tagctgggca   3600

tgatggcggg tgcctgtaat cccagctact cgggaggctg aggcaggata gtcgcttgaa   3660

cccaggaggt ggaggttgca atgagccaag atcatgccac tgcactccag cctggacgac   3720

agagtgagac tccatcacaa gaaaaaaaga actttgtcaa cctctgtctt agggcgcctt   3780

gtcacaggct tcgggtcaga cggattcaac cttgcatcag ccatttgtta gccaggtcac   3840

tctgttcttt gtctgtaaat gagattgatc gttgttccca ctgagagtgt cagctccttc   3900

ccgtagagca ggcatgatga ttgtactcac ctctgacacc attgtgagtg ccacattcct   3960

tcccacgtcc ttgtcactgt aagagatgcc cacctgagca ccaaccccag gttatcttcc   4020

cctttgtctt ccagcccccc agaaacagct acgactcaac ctacccaatc atttcatcat   4080

cagattgcca ctgtctctag ttcaggtctc ttgggactgg cactcagaaa tctcataata   4140

aatcctcttg aggcttctca tacactcgtc ttcttccaat cttctttccc tcaaaatctc   4200

atattttggt tccacttcac ccaccgtcat tctccatatc actcccagga gttaggcaaa   4260

aagccccttc cgttcttccg tatgttaaac ttagaatcac tctgttccct gctctgcgtt   4320

tctatttttt gtttttcctc catttactag tagcttaaca ctttctaaca gtgttcttat   4380

tattgatacg tatctatctc ttccataagc ttataaggtc acggataata cttctcattg   4440

tagtacgtaa atgacgtggg ctagatatga gttgaataaa cagttatacc tgtaaattct   4500

tacagagtga aaataaattg ttatacttta caatttgttt ctctctttag accatttcca   4560

ggacttgtga ttaataaccg tgagtatttt gtgaagtgtt ttgtttttgt tttttcctgg   4620

ggtctgacgt gtgtgcgtgt gagtgtgtat acatgcttaa cgtatatcac gttacttcac   4680

ctatgtcagt aaccaggcca aatacttgtt ttagccctca gtaaaaacac caggcacttc   4740

ctagttgtaa aattattcaa gcttcttaac ttcctatcct cgatgcactt aatcataaaa   4800

tggtaataat agcaccgatt ttgggggagt cgttccagta gatggaaagc atctggaaca   4860

ggtgtcagca agctcctgcc gacgtgtatg cataaagttt tattgaaacc accatcgtgt   4920

ccatttgttt atggcagaac tgagagatgg cagcagcaag tgtgtgcctg caaaacctaa   4980

aatatttact aattggctct gcaagaaaag agtttgcatc cccctaacct agaacagtgt   5040

ctagcctcta gtatgtgttt agcctacagt atgtgctcag cgaatacaat ctatatttat   5100

tactgctttt atgactgtta taattactgt gcttggattt cgttacaaag taagtcacaa   5160

tgtgcctgct tctgttagta tttcagcaca gtgcctggca cacatggggc tctcaaatat   5220

tgctgagcga gtgaacaaat gtcctttcaa ttccttaacg ttgatgtcat tttcaatagt   5280

attttgagcc aaacttaatt ttgcgagtgt gttttgtttt cttaacttta ttattaaaaa   5340

tgtataaaag tgaggccagg cgtggtggct cacgcctgta atcccagcag tttgggaggc   5400

tgaggcaggc ggatcagttg aggttgggag ttggagacca gcccgtccaa catggtgaaa   5460

gcctgtctct actaaaaata caaaaatcag ctgggtgtgg tggcgcgtgc ctgtaatccc   5520

agctactcag gaggctgagg caggagagtt gcttgaatcc tagaggtgga ggttgcagtg   5580

agctgagatc gtgccattgc actccagcct gggcaacaag agcaaaactc tgtcccaata   5640

aataaataaa taaaatgttc tcttttgttc ctgttcttgt gcggtagtgt ggtatagagt   5700

tttatggtaa ttactgtgaa ttagtgattc tgagggacat atcagaactc tgaggtttgt   5760

ttccttctca tcttgaggga aacagcaaat gtatgttaaa atgcttttcc aagggaacaa   5820

cacatcctta cattatttaa accaatctgc ttcattttca gagctggttg atcagagtga   5880

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   5940

agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag accccacgtg   6000

gtagacctct tccctcctag ggtaaatcag cttctgtgtc agggatgctg tgtggtgtcc   6060

atctgaaccc cctgcatacg cgtagctaat gtgatctccc cactttcaca taagatggtg   6120

gccctgcctt cagggaatgt gggagccagg tgggagcctt cccggatatt taagctagaa   6180

gattctacag ggagattctc cttggatcaa tatatgtctc tcagtcaaag atgtaaaagc   6240

acttttgcct taaaaagaat gttctgtttc taaatagagt caacgttgtc ctcctcattg   6300

gaattcacta tgagtcagaa tcattagact gacttttttt tttccatagt aatagtattt   6360

tgcagagtct cacagagctg cagatctttt gttcatcttg cagagttaac aagtctgatc   6420

ctgttagtcc agatttctta aatttggcca agttataata ggagcagtag cttgagaccc   6480

gaagtcagga aactttgaca atggattttt ttttttaatc cagagacttg tactggaatt   6540

tgccttaccc tgtcagctca tggacttaag gtttcatccc gctttatgag tgcttctgaa   6600

tccaagtcat tgttacctga atttgcaaat taagttgtga tattcgtgac tgttaaattc   6660

ctgtaattag attaacctct ttgcttgctt gtttgttttc tctcctattt tagcttaaag   6720

tatcagtggt tgagaagagc ttttcggacc tgttactacc ccaagctgtg taatatactt   6780

gtataacaga aataccttct atacaaacct ttttttctac ttttagatag aaatgtctac   6840

tttttcagca gttctgtgaa ttaaagagca gagtgactgt gggtctggaa tggctggtgt   6900

acttgggaat gtactatcag gattttacag caatgctggg aaatgacagg gaaaatgaca   6960

ggaatgaatc tcaccagatt ttttatgtac tcagcagagc cttgagttac ggtgtttatt   7020

ttccaatcaa gtgaagatat ctcctacttc tcctactgga acatctcagc ttctgcagtg   7080

aagaaaaatt cctgtgatag ttcagttctt tagtttttct atttgaaaaa aaaaaatcat   7140

ttaaatgatc ctttgttcac ggctctcctt aatgactgag tgaacagttc ctatctgtat   7200

atttgactaa accttttcct aagctatctc tcatggttcc tatgtttttt tatcataatt   7260

aaaagcaaaa ccatctggat cacctaacag tcagaggtca gtatctcagc gtgtgaatta   7320

tagaggaaat acagagagaa cctcttccac ttttactttt cgtccaaata aaatgcatgg   7380

tgtaccagaa gttgaagatc gggttgagga ttggggctag ctcgatgaca ctaaggcccc   7440

aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg ctgttctagc cggccccctc   7500

tccaggggtc gccgtggccg gcattatttc ctagttcttc ttgtaaccct gaggtgccag   7560

cgcggggagt gaggaggggt cagggggcta aggatgcaac ctctgacgtt ctgcgccttc   7620

ctaggagagt cttacatgtg ttgagatttc acaagcaatg cgagttgtaa aataccagct   7680

ctacaagaag ctaggctctg tgacggcata gttttcagta gctttatcac aatattcaca   7740

atggagaatt atatgacatg gtagcagaaa taggcccttt tatgtgttgc ttctatttta   7800

cctcaaattg tagatatagg gtaatcaata aaatccatcc atgcctttca cacactaagt   7860


<210>  5033
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  5033

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  5034
<211>  4920
<212>  DNA
<213>  Homo sapiens

<400>  5034
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1080

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1140

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1200

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1260

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1320

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1380

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1440

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1500

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1560

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1620

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1680

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1740

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1800

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1860

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1920

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   1980

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2040

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2100

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2160

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2220

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2280

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2340

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2400

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2460

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2520

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2580

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2640

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2700

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2760

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2820

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   2880

cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg atcagagtga   2940

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   3000

agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag accccacgtg   3060

gtagacctct tccctcctag ggtaaatcag cttctgtgtc agggatgctg tgtggtgtcc   3120

atctgaaccc cctgcatacg cgtagctaat gtgatctccc cactttcaca taagatggtg   3180

gccctgcctt cagggaatgt gggagccagg tgggagcctt cccggatatt taagctagaa   3240

gattctacag ggagattctc cttggatcaa tatatgtctc tcagtcaaag atgtaaaagc   3300

acttttgcct taaaaagaat gttctgtttc taaatagagt caacgttgtc ctcctcattg   3360

gaattcacta tgagtcagaa tcattagact gacttttttt tttccatagt aatagtattt   3420

tgcagagtct cacagagctg cagatctttt gttcatcttg cagagttaac aagtctgatc   3480

ctgttagtcc agatttctta aatttggcca agttataata ggagcagtag cttgagaccc   3540

gaagtcagga aactttgaca atggattttt ttttttaatc cagagacttg tactggaatt   3600

tgccttaccc tgtcagctca tggacttaag gtttcatccc gctttatgag tgcttctgaa   3660

tccaagtcat tgttacctga atttgcaaat taagttgtga tattcgtgac tgttaaattc   3720

ctgtaattag attaacctct ttgcttgctt gtttgttttc tctcctattt tagcttaaag   3780

tatcagtggt tgagaagagc ttttcggacc tgttactacc ccaagctgtg taatatactt   3840

gtataacaga aataccttct atacaaacct ttttttctac ttttagatag aaatgtctac   3900

tttttcagca gttctgtgaa ttaaagagca gagtgactgt gggtctggaa tggctggtgt   3960

acttgggaat gtactatcag gattttacag caatgctggg aaatgacagg gaaaatgaca   4020

ggaatgaatc tcaccagatt ttttatgtac tcagcagagc cttgagttac ggtgtttatt   4080

ttccaatcaa gtgaagatat ctcctacttc tcctactgga acatctcagc ttctgcagtg   4140

aagaaaaatt cctgtgatag ttcagttctt tagtttttct atttgaaaaa aaaaaatcat   4200

ttaaatgatc ctttgttcac ggctctcctt aatgactgag tgaacagttc ctatctgtat   4260

atttgactaa accttttcct aagctatctc tcatggttcc tatgtttttt tatcataatt   4320

aaaagcaaaa ccatctggat cacctaacag tcagaggtca gtatctcagc gtgtgaatta   4380

tagaggaaat acagagagaa cctcttccac ttttactttt cgtccaaata aaatgcatgg   4440

tgtaccagaa gttgaagatc gggttgagga ttggggctag ctcgatgaca ctaaggcccc   4500

aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg ctgttctagc cggccccctc   4560

tccaggggtc gccgtggccg gcattatttc ctagttcttc ttgtaaccct gaggtgccag   4620

cgcggggagt gaggaggggt cagggggcta aggatgcaac ctctgacgtt ctgcgccttc   4680

ctaggagagt cttacatgtg ttgagatttc acaagcaatg cgagttgtaa aataccagct   4740

ctacaagaag ctaggctctg tgacggcata gttttcagta gctttatcac aatattcaca   4800

atggagaatt atatgacatg gtagcagaaa taggcccttt tatgtgttgc ttctatttta   4860

cctcaaattg tagatatagg gtaatcaata aaatccatcc atgcctttca cacactaagt   4920


<210>  5035
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  5035

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
                565                 570                 575


Ser Ser Leu Leu Lys Asn Leu Asn 
            580


<210>  5036
<211>  5111
<212>  DNA
<213>  Homo sapiens

<400>  5036
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1080

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1140

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1200

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1260

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1320

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1380

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1440

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1500

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1560

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1620

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1680

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1740

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1800

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1860

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1920

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   1980

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2040

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2100

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2160

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2220

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2280

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2340

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2400

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2460

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2520

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2580

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2640

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2700

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2760

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2820

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   2880

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   2940

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3000

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3060

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3120

ttcacggtca ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt   3180

gagtcagaag gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc   3240

acagaaggta aaaggacctc ttccctccta gggtaaatca gcttctgtgt cagggatgct   3300

gtgtggtgtc catctgaacc ccctgcatac gcgtagctaa tgtgatctcc ccactttcac   3360

ataagatggt ggccctgcct tcagggaatg tgggagccag gtgggagcct tcccggatat   3420

ttaagctaga agattctaca gggagattct ccttggatca atatatgtct ctcagtcaaa   3480

gatgtaaaag cacttttgcc ttaaaaagaa tgttctgttt ctaaatagag tcaacgttgt   3540

cctcctcatt ggaattcact atgagtcaga atcattagac tgactttttt ttttccatag   3600

taatagtatt ttgcagagtc tcacagagct gcagatcttt tgttcatctt gcagagttaa   3660

caagtctgat cctgttagtc cagatttctt aaatttggcc aagttataat aggagcagta   3720

gcttgagacc cgaagtcagg aaactttgac aatggatttt tttttttaat ccagagactt   3780

gtactggaat ttgccttacc ctgtcagctc atggacttaa ggtttcatcc cgctttatga   3840

gtgcttctga atccaagtca ttgttacctg aatttgcaaa ttaagttgtg atattcgtga   3900

ctgttaaatt cctgtaatta gattaacctc tttgcttgct tgtttgtttt ctctcctatt   3960

ttagcttaaa gtatcagtgg ttgagaagag cttttcggac ctgttactac cccaagctgt   4020

gtaatatact tgtataacag aaataccttc tatacaaacc tttttttcta cttttagata   4080

gaaatgtcta ctttttcagc agttctgtga attaaagagc agagtgactg tgggtctgga   4140

atggctggtg tacttgggaa tgtactatca ggattttaca gcaatgctgg gaaatgacag   4200

ggaaaatgac aggaatgaat ctcaccagat tttttatgta ctcagcagag ccttgagtta   4260

cggtgtttat tttccaatca agtgaagata tctcctactt ctcctactgg aacatctcag   4320

cttctgcagt gaagaaaaat tcctgtgata gttcagttct ttagtttttc tatttgaaaa   4380

aaaaaaatca tttaaatgat cctttgttca cggctctcct taatgactga gtgaacagtt   4440

cctatctgta tatttgacta aaccttttcc taagctatct ctcatggttc ctatgttttt   4500

ttatcataat taaaagcaaa accatctgga tcacctaaca gtcagaggtc agtatctcag   4560

cgtgtgaatt atagaggaaa tacagagaga acctcttcca cttttacttt tcgtccaaat   4620

aaaatgcatg gtgtaccaga agttgaagat cgggttgagg attggggcta gctcgatgac   4680

actaaggccc caacatcgcg ggacctgctg tggcgcggat tcttaggaac gctgttctag   4740

ccggccccct ctccaggggt cgccgtggcc ggcattattt cctagttctt cttgtaaccc   4800

tgaggtgcca gcgcggggag tgaggagggg tcagggggct aaggatgcaa cctctgacgt   4860

tctgcgcctt cctaggagag tcttacatgt gttgagattt cacaagcaat gcgagttgta   4920

aaataccagc tctacaagaa gctaggctct gtgacggcat agttttcagt agctttatca   4980

caatattcac aatggagaat tatatgacat ggtagcagaa ataggccctt ttatgtgttg   5040

cttctatttt acctcaaatt gtagatatag ggtaatcaat aaaatccatc catgcctttc   5100

acacactaag t                                                        5111


<210>  5037
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  5037

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala 



<210>  5038
<211>  4130
<212>  DNA
<213>  Homo sapiens

<400>  5038
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1080

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1140

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1200

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1260

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1320

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1380

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1440

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1500

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1560

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1620

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1680

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1740

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1800

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1860

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1920

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   1980

taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2040

ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2100

ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2160

ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2220

ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2280

atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2340

agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2400

agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2460

tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2520

ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2580

tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2640

ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2700

atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2760

ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2820

tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   2880

ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   2940

tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3000

ttatcaaatt cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg   3060

atcagagtga gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag   3120

ttccagccac agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag   3180

accccacgtg gtagacctct tccctcctag gcttaaagta tcagtggttg agaagagctt   3240

ttcggacctg ttactacccc aagctgtagc cttgagttac ggtgtttatt ttccaatcaa   3300

gtgaagatat ctcctacttc tcctactgga acatctcagc ttctgcagtg aagaaaaatt   3360

cctgtgatag ttcagttctt tagtttttct atttgaaaaa aaaaaatcat ttaaatgatc   3420

ctttgttcac ggctctcctt aatgactgag tgaacagttc ctatctgtat atttgactaa   3480

accttttcct aagctatctc tcatggttcc tatgtttttt tatcataatt aaaagcaaaa   3540

ccatctggat cacctaacag tcagaggtca gtatctcagc gtgtgaatta tagaggaaat   3600

acagagagaa cctcttccac ttttactttt cgtccaaata aaatgcatgg tgtaccagaa   3660

gttgaagatc gggttgagga ttggggctag ctcgatgaca ctaaggcccc aacatcgcgg   3720

gacctgctgt ggcgcggatt cttaggaacg ctgttctagc cggccccctc tccaggggtc   3780

gccgtggccg gcattatttc ctagttcttc ttgtaaccct gaggtgccag cgcggggagt   3840

gaggaggggt cagggggcta aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt   3900

cttacatgtg ttgagatttc acaagcaatg cgagttgtaa aataccagct ctacaagaag   3960

ctaggctctg tgacggcata gttttcagta gctttatcac aatattcaca atggagaatt   4020

atatgacatg gtagcagaaa taggcccttt tatgtgttgc ttctatttta cctcaaattg   4080

tagatatagg gtaatcaata aaatccatcc atgcctttca cacactaagt              4130


<210>  5039
<211>  978
<212>  PRT
<213>  Homo sapiens

<400>  5039

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu 
            580                 585                 590


Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg 
        595                 600                 605


Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys 
    610                 615                 620


Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys 
625                 630                 635                 640


Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly 
                645                 650                 655


Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn 
            660                 665                 670


Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn 
        675                 680                 685


Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu 
    690                 695                 700


Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu 
705                 710                 715                 720


Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys 
                725                 730                 735


Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu 
            740                 745                 750


Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile 
        755                 760                 765


Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile 
    770                 775                 780


Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser 
785                 790                 795                 800


Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr 
                805                 810                 815


Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro 
            820                 825                 830


Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu 
        835                 840                 845


Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile 
    850                 855                 860


Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn 
865                 870                 875                 880


Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys 
                885                 890                 895


Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser 
            900                 905                 910


Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val 
        915                 920                 925


Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile 
    930                 935                 940


Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu 
945                 950                 955                 960


Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro 
                965                 970                 975


Thr Trp 



<210>  5040
<211>  4358
<212>  DNA
<213>  Homo sapiens

<400>  5040
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1080

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1140

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1200

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1260

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1320

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1380

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1440

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1500

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1560

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1620

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1680

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1740

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1800

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1860

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1920

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   1980

taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2040

ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2100

ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2160

ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2220

ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2280

atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2340

agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2400

agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2460

tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2520

ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2580

tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2640

ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2700

atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2760

ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2820

tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   2880

ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   2940

tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3000

ttatcaaatt cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg   3060

atcagagtga gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag   3120

ttccagccac agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag   3180

accccacgtg gtagacctct tccctcctag gcttaaagta tcagtggttg agaagagctt   3240

ttcggacctg ttactacccc aagctgtgta atatacttgt ataacagaaa taccttctat   3300

acaaaccttt ttttctactt ttagatagaa atgtctactt tttcagcagt tctgtgaatt   3360

aaagagcaga gtgactgtgg gtctggaatg gctggtgtac ttgggaatgt actatcagga   3420

ttttacagca atgctgggaa atgacaggga aaatgacagg aatgaatctc accagatttt   3480

ttatgtactc agcagagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct   3540

cctacttctc ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt   3600

cagttcttta gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg   3660

ctctccttaa tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa   3720

gctatctctc atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca   3780

cctaacagtc agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc   3840

tcttccactt ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg   3900

gttgaggatt ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg   3960

cgcggattct taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc   4020

attatttcct agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca   4080

gggggctaag gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt   4140

gagatttcac aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg   4200

acggcatagt tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt   4260

agcagaaata ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt   4320

aatcaataaa atccatccat gcctttcaca cactaagt                           4358


<210>  5041
<211>  978
<212>  PRT
<213>  Homo sapiens

<400>  5041

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu 
            580                 585                 590


Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg 
        595                 600                 605


Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys 
    610                 615                 620


Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys 
625                 630                 635                 640


Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly 
                645                 650                 655


Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn 
            660                 665                 670


Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn 
        675                 680                 685


Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu 
    690                 695                 700


Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu 
705                 710                 715                 720


Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys 
                725                 730                 735


Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu 
            740                 745                 750


Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile 
        755                 760                 765


Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile 
    770                 775                 780


Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser 
785                 790                 795                 800


Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr 
                805                 810                 815


Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro 
            820                 825                 830


Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu 
        835                 840                 845


Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile 
    850                 855                 860


Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn 
865                 870                 875                 880


Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys 
                885                 890                 895


Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser 
            900                 905                 910


Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val 
        915                 920                 925


Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile 
    930                 935                 940


Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu 
945                 950                 955                 960


Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro 
                965                 970                 975


Thr Trp 



<210>  5042
<211>  4987
<212>  DNA
<213>  Homo sapiens

<400>  5042
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   1980

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   2040

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2100

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2160

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2220

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2280

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2340

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2400

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2460

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2520

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2580

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2640

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2700

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2760

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2820

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2880

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   2940

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   3000

cggtcattag accatttcca ggacttgtga ttaataacca gctggttgat cagagtgagt   3060

cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt ccagccacag   3120

aaggtaaaag gacctcttcc ctcctagggt aaatcagctt ctgtgtcagg gatgctgtgt   3180

ggtgtccatc tgaaccccct gcatacgcgt agctaatgtg atctccccac tttcacataa   3240

gatggtggcc ctgccttcag ggaatgtggg agccaggtgg gagccttccc ggatatttaa   3300

gctagaagat tctacaggga gattctcctt ggatcaatat atgtctctca gtcaaagatg   3360

taaaagcact tttgccttaa aaagaatgtt ctgtttctaa atagagtcaa cgttgtcctc   3420

ctcattggaa ttcactatga gtcagaatca ttagactgac tttttttttt ccatagtaat   3480

agtattttgc agagtctcac agagctgcag atcttttgtt catcttgcag agttaacaag   3540

tctgatcctg ttagtccaga tttcttaaat ttggccaagt tataatagga gcagtagctt   3600

gagacccgaa gtcaggaaac tttgacaatg gatttttttt tttaatccag agacttgtac   3660

tggaatttgc cttaccctgt cagctcatgg acttaaggtt tcatcccgct ttatgagtgc   3720

ttctgaatcc aagtcattgt tacctgaatt tgcaaattaa gttgtgatat tcgtgactgt   3780

taaattcctg taattagatt aacctctttg cttgcttgtt tgttttctct cctattttag   3840

cttaaagtat cagtggttga gaagagcttt tcggacctgt tactacccca agctgtgtaa   3900

tatacttgta taacagaaat accttctata caaacctttt tttctacttt tagatagaaa   3960

tgtctacttt ttcagcagtt ctgtgaatta aagagcagag tgactgtggg tctggaatgg   4020

ctggtgtact tgggaatgta ctatcaggat tttacagcaa tgctgggaaa tgacagggaa   4080

aatgacagga atgaatctca ccagattttt tatgtactca gcagagcctt gagttacggt   4140

gtttattttc caatcaagtg aagatatctc ctacttctcc tactggaaca tctcagcttc   4200

tgcagtgaag aaaaattcct gtgatagttc agttctttag tttttctatt tgaaaaaaaa   4260

aaatcattta aatgatcctt tgttcacggc tctccttaat gactgagtga acagttccta   4320

tctgtatatt tgactaaacc ttttcctaag ctatctctca tggttcctat gtttttttat   4380

cataattaaa agcaaaacca tctggatcac ctaacagtca gaggtcagta tctcagcgtg   4440

tgaattatag aggaaataca gagagaacct cttccacttt tacttttcgt ccaaataaaa   4500

tgcatggtgt accagaagtt gaagatcggg ttgaggattg gggctagctc gatgacacta   4560

aggccccaac atcgcgggac ctgctgtggc gcggattctt aggaacgctg ttctagccgg   4620

ccccctctcc aggggtcgcc gtggccggca ttatttccta gttcttcttg taaccctgag   4680

gtgccagcgc ggggagtgag gaggggtcag ggggctaagg atgcaacctc tgacgttctg   4740

cgccttccta ggagagtctt acatgtgttg agatttcaca agcaatgcga gttgtaaaat   4800

accagctcta caagaagcta ggctctgtga cggcatagtt ttcagtagct ttatcacaat   4860

attcacaatg gagaattata tgacatggta gcagaaatag gcccttttat gtgttgcttc   4920

tattttacct caaattgtag atatagggta atcaataaaa tccatccatg cctttcacac   4980

actaagt                                                             4987


<210>  5043
<211>  964
<212>  PRT
<213>  Homo sapiens

<400>  5043

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala 
545                 550                 555                 560


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
                565                 570                 575


Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile 
            580                 585                 590


Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile 
        595                 600                 605


Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu 
    610                 615                 620


Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys 
625                 630                 635                 640


Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys 
                645                 650                 655


Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro 
            660                 665                 670


Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val 
        675                 680                 685


Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala 
    690                 695                 700


Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys 
705                 710                 715                 720


Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala 
                725                 730                 735


Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu 
            740                 745                 750


Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu 
        755                 760                 765


Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro 
    770                 775                 780


Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro 
785                 790                 795                 800


Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly 
                805                 810                 815


Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn 
            820                 825                 830


Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val 
        835                 840                 845


Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe 
    850                 855                 860


Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val 
865                 870                 875                 880


Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr 
                885                 890                 895


Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile 
            900                 905                 910


Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln 
        915                 920                 925


Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala 
    930                 935                 940


Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Gly Lys Arg Thr Ser 
945                 950                 955                 960


Ser Leu Leu Gly 



<210>  5044
<211>  4929
<212>  DNA
<213>  Homo sapiens

<400>  5044
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1980

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   2040

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2100

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2160

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2220

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2280

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2340

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2400

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2460

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2520

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2580

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2640

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2700

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2760

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2820

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2880

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   2940

cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg atcagagtga   3000

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   3060

agaaggtaaa aggacctctt ccctcctagg gtaaatcagc ttctgtgtca gggatgctgt   3120

gtggtgtcca tctgaacccc ctgcatacgc gtagctaatg tgatctcccc actttcacat   3180

aagatggtgg ccctgccttc agggaatgtg ggagccaggt gggagccttc ccggatattt   3240

aagctagaag attctacagg gagattctcc ttggatcaat atatgtctct cagtcaaaga   3300

tgtaaaagca cttttgcctt aaaaagaatg ttctgtttct aaatagagtc aacgttgtcc   3360

tcctcattgg aattcactat gagtcagaat cattagactg actttttttt ttccatagta   3420

atagtatttt gcagagtctc acagagctgc agatcttttg ttcatcttgc agagttaaca   3480

agtctgatcc tgttagtcca gatttcttaa atttggccaa gttataatag gagcagtagc   3540

ttgagacccg aagtcaggaa actttgacaa tggatttttt tttttaatcc agagacttgt   3600

actggaattt gccttaccct gtcagctcat ggacttaagg tttcatcccg ctttatgagt   3660

gcttctgaat ccaagtcatt gttacctgaa tttgcaaatt aagttgtgat attcgtgact   3720

gttaaattcc tgtaattaga ttaacctctt tgcttgcttg tttgttttct ctcctatttt   3780

agcttaaagt atcagtggtt gagaagagct tttcggacct gttactaccc caagctgtgt   3840

aatatacttg tataacagaa ataccttcta tacaaacctt tttttctact tttagataga   3900

aatgtctact ttttcagcag ttctgtgaat taaagagcag agtgactgtg ggtctggaat   3960

ggctggtgta cttgggaatg tactatcagg attttacagc aatgctggga aatgacaggg   4020

aaaatgacag gaatgaatct caccagattt tttatgtact cagcagagcc ttgagttacg   4080

gtgtttattt tccaatcaag tgaagatatc tcctacttct cctactggaa catctcagct   4140

tctgcagtga agaaaaattc ctgtgatagt tcagttcttt agtttttcta tttgaaaaaa   4200

aaaaatcatt taaatgatcc tttgttcacg gctctcctta atgactgagt gaacagttcc   4260

tatctgtata tttgactaaa ccttttccta agctatctct catggttcct atgttttttt   4320

atcataatta aaagcaaaac catctggatc acctaacagt cagaggtcag tatctcagcg   4380

tgtgaattat agaggaaata cagagagaac ctcttccact tttacttttc gtccaaataa   4440

aatgcatggt gtaccagaag ttgaagatcg ggttgaggat tggggctagc tcgatgacac   4500

taaggcccca acatcgcggg acctgctgtg gcgcggattc ttaggaacgc tgttctagcc   4560

ggccccctct ccaggggtcg ccgtggccgg cattatttcc tagttcttct tgtaaccctg   4620

aggtgccagc gcggggagtg aggaggggtc agggggctaa ggatgcaacc tctgacgttc   4680

tgcgccttcc taggagagtc ttacatgtgt tgagatttca caagcaatgc gagttgtaaa   4740

ataccagctc tacaagaagc taggctctgt gacggcatag ttttcagtag ctttatcaca   4800

atattcacaa tggagaatta tatgacatgg tagcagaaat aggccctttt atgtgttgct   4860

tctattttac ctcaaattgt agatataggg taatcaataa aatccatcca tgcctttcac   4920

acactaagt                                                           4929


<210>  5045
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  5045

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
                565                 570                 575


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly 
            580                 585                 590


Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600


<210>  5046
<211>  7119
<212>  DNA
<213>  Homo sapiens

<400>  5046
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1080

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1140

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1200

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1260

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1320

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1380

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1440

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1500

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1560

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1620

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1680

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1740

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1800

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1860

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1920

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   1980

taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2040

ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2100

ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2160

ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2220

ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2280

atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2340

agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2400

agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2460

tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2520

ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2580

tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2640

ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2700

atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2760

ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2820

tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   2880

ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   2940

tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3000

ttatcaaatt cacggtcatt aggtaagtga gagtttcctg cttagtcaca ggagcgaatc   3060

tggagctcat gaggctgact cttctaaaat gcagccacag gtagtcatcg aatccggctt   3120

cctatgctgt gcaatcaaca aatcaaaata acttgtgtca tcattagaat gtcagatgtg   3180

cttctacgaa ctaagctgac tcttttaatt ctttggcaaa gggttggcaa actaggactg   3240

tttgccaaat tcaggctgcc tcctattttt agagtcttcc tgaaacacag ctacacccgt   3300

attatccatg gctgctttcc tgtcacagtg agtaagtagc tgggactgag aaggcatggc   3360

ctccaaagtc taaaatattt actctctagc actttgtaga aaaaccttag ctaggcacag   3420

tggctaacgc ctgtaatccc agcattttgg gaggccaagg caggcagatc acctgaggtc   3480

aggagttcca gaccagcctg gccaacatgg tgaaatccca tctctacaaa aataaaacag   3540

ttagctgggc atgatggcgg gtgcctgtaa tcccagctac tcgggaggct gaggcaggat   3600

agtcgcttga acccaggagg tggaggttgc aatgagccaa gatcatgcca ctgcactcca   3660

gcctggacga cagagtgaga ctccatcaca agaaaaaaag aactttgtca acctctgtct   3720

tagggcgcct tgtcacaggc ttcgggtcag acggattcaa ccttgcatca gccatttgtt   3780

agccaggtca ctctgttctt tgtctgtaaa tgagattgat cgttgttccc actgagagtg   3840

tcagctcctt cccgtagagc aggcatgatg attgtactca cctctgacac cattgtgagt   3900

gccacattcc ttcccacgtc cttgtcactg taagagatgc ccacctgagc accaacccca   3960

ggttatcttc ccctttgtct tccagccccc cagaaacagc tacgactcaa cctacccaat   4020

catttcatca tcagattgcc actgtctcta gttcaggtct cttgggactg gcactcagaa   4080

atctcataat aaatcctctt gaggcttctc atacactcgt cttcttccaa tcttctttcc   4140

ctcaaaatct catattttgg ttccacttca cccaccgtca ttctccatat cactcccagg   4200

agttaggcaa aaagcccctt ccgttcttcc gtatgttaaa cttagaatca ctctgttccc   4260

tgctctgcgt ttctattttt tgtttttcct ccatttacta gtagcttaac actttctaac   4320

agtgttctta ttattgatac gtatctatct cttccataag cttataaggt cacggataat   4380

acttctcatt gtagtacgta aatgacgtgg gctagatatg agttgaataa acagttatac   4440

ctgtaaattc ttacagagtg aaaataaatt gttatacttt acaatttgtt tctctcttta   4500

gaccatttcc aggacttgtg attaataacc gtgagtattt tgtgaagtgt tttgtttttg   4560

ttttttcctg gggtctgacg tgtgtgcgtg tgagtgtgta tacatgctta acgtatatca   4620

cgttacttca cctatgtcag taaccaggcc aaatacttgt tttagccctc agtaaaaaca   4680

ccaggcactt cctagttgta aaattattca agcttcttaa cttcctatcc tcgatgcact   4740

taatcataaa atggtaataa tagcaccgat tttgggggag tcgttccagt agatggaaag   4800

catctggaac aggtgtcagc aagctcctgc cgacgtgtat gcataaagtt ttattgaaac   4860

caccatcgtg tccatttgtt tatggcagaa ctgagagatg gcagcagcaa gtgtgtgcct   4920

gcaaaaccta aaatatttac taattggctc tgcaagaaaa gagtttgcat ccccctaacc   4980

tagaacagtg tctagcctct agtatgtgtt tagcctacag tatgtgctca gcgaatacaa   5040

tctatattta ttactgcttt tatgactgtt ataattactg tgcttggatt tcgttacaaa   5100

gtaagtcaca atgtgcctgc ttctgttagt atttcagcac agtgcctggc acacatgggg   5160

ctctcaaata ttgctgagcg agtgaacaaa tgtcctttca attccttaac gttgatgtca   5220

ttttcaatag tattttgagc caaacttaat tttgcgagtg tgttttgttt tcttaacttt   5280

attattaaaa atgtataaaa gtgaggccag gcgtggtggc tcacgcctgt aatcccagca   5340

gtttgggagg ctgaggcagg cggatcagtt gaggttggga gttggagacc agcccgtcca   5400

acatggtgaa agcctgtctc tactaaaaat acaaaaatca gctgggtgtg gtggcgcgtg   5460

cctgtaatcc cagctactca ggaggctgag gcaggagagt tgcttgaatc ctagaggtgg   5520

aggttgcagt gagctgagat cgtgccattg cactccagcc tgggcaacaa gagcaaaact   5580

ctgtcccaat aaataaataa ataaaatgtt ctcttttgtt cctgttcttg tgcggtagtg   5640

tggtatagag ttttatggta attactgtga attagtgatt ctgagggaca tatcagaact   5700

ctgaggtttg tttccttctc atcttgaggg aaacagcaaa tgtatgttaa aatgcttttc   5760

caagggaaca acacatcctt acattattta aaccaatctg cttcattttc agagctggtt   5820

gatcagagtg agtcagaagg ccccgtgata caagaatcag ctgaaccaag ccagttggaa   5880

gttccagcca cagaagaaat aaaagagact gatggaagct ctcagatcaa gcaagaacca   5940

gaccccacgt ggtagacctc ttccctccta ggcttaaagt atcagtggtt gagaagagct   6000

tttcggacct gttactaccc caagctgtgt aatatacttg tataacagaa ataccttcta   6060

tacaaacctt tttttctact tttagataga aatgtctact ttttcagcag ttctgtgaat   6120

taaagagcag agtgactgtg ggtctggaat ggctggtgta cttgggaatg tactatcagg   6180

attttacagc aatgctggga aatgacaggg aaaatgacag gaatgaatct caccagattt   6240

tttatgtact cagcagagcc ttgagttacg gtgtttattt tccaatcaag tgaagatatc   6300

tcctacttct cctactggaa catctcagct tctgcagtga agaaaaattc ctgtgatagt   6360

tcagttcttt agtttttcta tttgaaaaaa aaaaatcatt taaatgatcc tttgttcacg   6420

gctctcctta atgactgagt gaacagttcc tatctgtata tttgactaaa ccttttccta   6480

agctatctct catggttcct atgttttttt atcataatta aaagcaaaac catctggatc   6540

acctaacagt cagaggtcag tatctcagcg tgtgaattat agaggaaata cagagagaac   6600

ctcttccact tttacttttc gtccaaataa aatgcatggt gtaccagaag ttgaagatcg   6660

ggttgaggat tggggctagc tcgatgacac taaggcccca acatcgcggg acctgctgtg   6720

gcgcggattc ttaggaacgc tgttctagcc ggccccctct ccaggggtcg ccgtggccgg   6780

cattatttcc tagttcttct tgtaaccctg aggtgccagc gcggggagtg aggaggggtc   6840

agggggctaa ggatgcaacc tctgacgttc tgcgccttcc taggagagtc ttacatgtgt   6900

tgagatttca caagcaatgc gagttgtaaa ataccagctc tacaagaagc taggctctgt   6960

gacggcatag ttttcagtag ctttatcaca atattcacaa tggagaatta tatgacatgg   7020

tagcagaaat aggccctttt atgtgttgct tctattttac ctcaaattgt agatataggg   7080

taatcaataa aatccatcca tgcctttcac acactaagt                          7119


<210>  5047
<211>  922
<212>  PRT
<213>  Homo sapiens

<400>  5047

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu 
            580                 585                 590


Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg 
        595                 600                 605


Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys 
    610                 615                 620


Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys 
625                 630                 635                 640


Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly 
                645                 650                 655


Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn 
            660                 665                 670


Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn 
        675                 680                 685


Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu 
    690                 695                 700


Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu 
705                 710                 715                 720


Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys 
                725                 730                 735


Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu 
            740                 745                 750


Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile 
        755                 760                 765


Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile 
    770                 775                 780


Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser 
785                 790                 795                 800


Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr 
                805                 810                 815


Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro 
            820                 825                 830


Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu 
        835                 840                 845


Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile 
    850                 855                 860


Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn 
865                 870                 875                 880


Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys 
                885                 890                 895


Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser 
            900                 905                 910


Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
        915                 920


<210>  5048
<211>  7733
<212>  DNA
<213>  Homo sapiens

<400>  5048
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag    960

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1020

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1080

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1140

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1200

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1260

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1320

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1380

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1440

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1500

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1560

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1620

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1680

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1740

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1800

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1860

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1920

aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc   1980

ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt   2040

tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa   2100

taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg   2160

ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg   2220

ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga gggagagagt   2280

tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct   2340

tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt   2400

tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc   2460

gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa   2520

ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct   2580

ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg   2640

ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga   2700

aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg   2760

gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc   2820

ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc   2880

tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca   2940

ttaggtaagt gagagtttcc tgcttagtca caggagcgaa tctggagctc atgaggctga   3000

ctcttctaaa atgcagccac aggtagtcat cgaatccggc ttcctatgct gtgcaatcaa   3060

caaatcaaaa taacttgtgt catcattaga atgtcagatg tgcttctacg aactaagctg   3120

actcttttaa ttctttggca aagggttggc aaactaggac tgtttgccaa attcaggctg   3180

cctcctattt ttagagtctt cctgaaacac agctacaccc gtattatcca tggctgcttt   3240

cctgtcacag tgagtaagta gctgggactg agaaggcatg gcctccaaag tctaaaatat   3300

ttactctcta gcactttgta gaaaaacctt agctaggcac agtggctaac gcctgtaatc   3360

ccagcatttt gggaggccaa ggcaggcaga tcacctgagg tcaggagttc cagaccagcc   3420

tggccaacat ggtgaaatcc catctctaca aaaataaaac agttagctgg gcatgatggc   3480

gggtgcctgt aatcccagct actcgggagg ctgaggcagg atagtcgctt gaacccagga   3540

ggtggaggtt gcaatgagcc aagatcatgc cactgcactc cagcctggac gacagagtga   3600

gactccatca caagaaaaaa agaactttgt caacctctgt cttagggcgc cttgtcacag   3660

gcttcgggtc agacggattc aaccttgcat cagccatttg ttagccaggt cactctgttc   3720

tttgtctgta aatgagattg atcgttgttc ccactgagag tgtcagctcc ttcccgtaga   3780

gcaggcatga tgattgtact cacctctgac accattgtga gtgccacatt ccttcccacg   3840

tccttgtcac tgtaagagat gcccacctga gcaccaaccc caggttatct tcccctttgt   3900

cttccagccc cccagaaaca gctacgactc aacctaccca atcatttcat catcagattg   3960

ccactgtctc tagttcaggt ctcttgggac tggcactcag aaatctcata ataaatcctc   4020

ttgaggcttc tcatacactc gtcttcttcc aatcttcttt ccctcaaaat ctcatatttt   4080

ggttccactt cacccaccgt cattctccat atcactccca ggagttaggc aaaaagcccc   4140

ttccgttctt ccgtatgtta aacttagaat cactctgttc cctgctctgc gtttctattt   4200

tttgtttttc ctccatttac tagtagctta acactttcta acagtgttct tattattgat   4260

acgtatctat ctcttccata agcttataag gtcacggata atacttctca ttgtagtacg   4320

taaatgacgt gggctagata tgagttgaat aaacagttat acctgtaaat tcttacagag   4380

tgaaaataaa ttgttatact ttacaatttg tttctctctt tagaccattt ccaggacttg   4440

tgattaataa ccgtgagtat tttgtgaagt gttttgtttt tgttttttcc tggggtctga   4500

cgtgtgtgcg tgtgagtgtg tatacatgct taacgtatat cacgttactt cacctatgtc   4560

agtaaccagg ccaaatactt gttttagccc tcagtaaaaa caccaggcac ttcctagttg   4620

taaaattatt caagcttctt aacttcctat cctcgatgca cttaatcata aaatggtaat   4680

aatagcaccg attttggggg agtcgttcca gtagatggaa agcatctgga acaggtgtca   4740

gcaagctcct gccgacgtgt atgcataaag ttttattgaa accaccatcg tgtccatttg   4800

tttatggcag aactgagaga tggcagcagc aagtgtgtgc ctgcaaaacc taaaatattt   4860

actaattggc tctgcaagaa aagagtttgc atccccctaa cctagaacag tgtctagcct   4920

ctagtatgtg tttagcctac agtatgtgct cagcgaatac aatctatatt tattactgct   4980

tttatgactg ttataattac tgtgcttgga tttcgttaca aagtaagtca caatgtgcct   5040

gcttctgtta gtatttcagc acagtgcctg gcacacatgg ggctctcaaa tattgctgag   5100

cgagtgaaca aatgtccttt caattcctta acgttgatgt cattttcaat agtattttga   5160

gccaaactta attttgcgag tgtgttttgt tttcttaact ttattattaa aaatgtataa   5220

aagtgaggcc aggcgtggtg gctcacgcct gtaatcccag cagtttggga ggctgaggca   5280

ggcggatcag ttgaggttgg gagttggaga ccagcccgtc caacatggtg aaagcctgtc   5340

tctactaaaa atacaaaaat cagctgggtg tggtggcgcg tgcctgtaat cccagctact   5400

caggaggctg aggcaggaga gttgcttgaa tcctagaggt ggaggttgca gtgagctgag   5460

atcgtgccat tgcactccag cctgggcaac aagagcaaaa ctctgtccca ataaataaat   5520

aaataaaatg ttctcttttg ttcctgttct tgtgcggtag tgtggtatag agttttatgg   5580

taattactgt gaattagtga ttctgaggga catatcagaa ctctgaggtt tgtttccttc   5640

tcatcttgag ggaaacagca aatgtatgtt aaaatgcttt tccaagggaa caacacatcc   5700

ttacattatt taaaccaatc tgcttcattt tcagagctgg ttgatcagag tgagtcagaa   5760

ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc cacagaagaa   5820

ataaaagaga ctgatggaag ctctcagatc aagcaagaac cagaccccac gtggtagacc   5880

tcttccctcc tagggtaaat cagcttctgt gtcagggatg ctgtgtggtg tccatctgaa   5940

ccccctgcat acgcgtagct aatgtgatct ccccactttc acataagatg gtggccctgc   6000

cttcagggaa tgtgggagcc aggtgggagc cttcccggat atttaagcta gaagattcta   6060

cagggagatt ctccttggat caatatatgt ctctcagtca aagatgtaaa agcacttttg   6120

ccttaaaaag aatgttctgt ttctaaatag agtcaacgtt gtcctcctca ttggaattca   6180

ctatgagtca gaatcattag actgactttt ttttttccat agtaatagta ttttgcagag   6240

tctcacagag ctgcagatct tttgttcatc ttgcagagtt aacaagtctg atcctgttag   6300

tccagatttc ttaaatttgg ccaagttata ataggagcag tagcttgaga cccgaagtca   6360

ggaaactttg acaatggatt ttttttttta atccagagac ttgtactgga atttgcctta   6420

ccctgtcagc tcatggactt aaggtttcat cccgctttat gagtgcttct gaatccaagt   6480

cattgttacc tgaatttgca aattaagttg tgatattcgt gactgttaaa ttcctgtaat   6540

tagattaacc tctttgcttg cttgtttgtt ttctctccta ttttagctta aagtatcagt   6600

ggttgagaag agcttttcgg acctgttact accccaagct gtgtaatata cttgtataac   6660

agaaatacct tctatacaaa cctttttttc tacttttaga tagaaatgtc tactttttca   6720

gcagttctgt gaattaaaga gcagagtgac tgtgggtctg gaatggctgg tgtacttggg   6780

aatgtactat caggatttta cagcaatgct gggaaatgac agggaaaatg acaggaatga   6840

atctcaccag attttttatg tactcagcag agccttgagt tacggtgttt attttccaat   6900

caagtgaaga tatctcctac ttctcctact ggaacatctc agcttctgca gtgaagaaaa   6960

attcctgtga tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat catttaaatg   7020

atcctttgtt cacggctctc cttaatgact gagtgaacag ttcctatctg tatatttgac   7080

taaacctttt cctaagctat ctctcatggt tcctatgttt ttttatcata attaaaagca   7140

aaaccatctg gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa ttatagagga   7200

aatacagaga gaacctcttc cacttttact tttcgtccaa ataaaatgca tggtgtacca   7260

gaagttgaag atcgggttga ggattggggc tagctcgatg acactaaggc cccaacatcg   7320

cgggacctgc tgtggcgcgg attcttagga acgctgttct agccggcccc ctctccaggg   7380

gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg   7440

agtgaggagg ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc ttcctaggag   7500

agtcttacat gtgttgagat ttcacaagca atgcgagttg taaaatacca gctctacaag   7560

aagctaggct ctgtgacggc atagttttca gtagctttat cacaatattc acaatggaga   7620

attatatgac atggtagcag aaataggccc ttttatgtgt tgcttctatt ttacctcaaa   7680

ttgtagatat agggtaatca ataaaatcca tccatgcctt tcacacacta agt          7733


<210>  5049
<211>  896
<212>  PRT
<213>  Homo sapiens

<400>  5049

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr 
                565                 570                 575


Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys 
            580                 585                 590


Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro 
        595                 600                 605


Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys 
    610                 615                 620


Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val 
625                 630                 635                 640


Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg 
                645                 650                 655


Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly 
            660                 665                 670


Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys 
        675                 680                 685


Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly 
    690                 695                 700


Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro 
705                 710                 715                 720


Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg 
                725                 730                 735


Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys 
            740                 745                 750


Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala 
        755                 760                 765


Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser 
    770                 775                 780


Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile 
785                 790                 795                 800


Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val 
                805                 810                 815


Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg 
            820                 825                 830


Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr 
        835                 840                 845


Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro 
    850                 855                 860


Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met 
865                 870                 875                 880


Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
                885                 890                 895


<210>  5050
<211>  4228
<212>  DNA
<213>  Homo sapiens

<400>  5050
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1080

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1140

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1200

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1260

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1320

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1380

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1440

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1500

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1560

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1620

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1680

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1740

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1800

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1860

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1920

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   1980

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2040

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2100

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2160

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2220

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2280

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2340

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2400

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2460

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2520

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2580

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2640

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2700

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2760

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2820

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   2880

cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg atcagagtga   2940

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   3000

agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag accccacgtg   3060

gtagacctct tccctcctag gcttaaagta tcagtggttg agaagagctt ttcggacctg   3120

ttactacccc aagctgtgta atatacttgt ataacagaaa taccttctat acaaaccttt   3180

ttttctactt ttagatagaa atgtctactt tttcagcagt tctgtgaatt aaagagcaga   3240

gtgactgtgg gtctggaatg gctggtgtac ttgggaatgt actatcagga ttttacagca   3300

atgctgggaa atgacaggga aaatgacagg aatgaatctc accagatttt ttatgtactc   3360

agcagagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct cctacttctc   3420

ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta   3480

gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg ctctccttaa   3540

tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa gctatctctc   3600

atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca cctaacagtc   3660

agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc tcttccactt   3720

ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg gttgaggatt   3780

ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg cgcggattct   3840

taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc attatttcct   3900

agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca gggggctaag   3960

gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt gagatttcac   4020

aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg acggcatagt   4080

tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt agcagaaata   4140

ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt aatcaataaa   4200

atccatccat gcctttcaca cactaagt                                      4228


<210>  5051
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  5051

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
                565                 570                 575


Ser Ser Leu Leu Lys Asn Leu Asn 
            580


<210>  5052
<211>  5162
<212>  DNA
<213>  Homo sapiens

<400>  5052
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1080

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1140

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1200

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1260

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1320

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1380

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1440

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1500

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1560

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1620

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1680

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1740

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1800

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1860

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1920

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   1980

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2040

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2100

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2160

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2220

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2280

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2340

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2400

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2460

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2520

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2580

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2640

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2700

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2760

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2820

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   2880

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   2940

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3000

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3060

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3120

ttcacggtca ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt   3180

gagtcagaag gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc   3240

acagaagaaa taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg   3300

tggtagacct cttccctcct agggtaaatc agcttctgtg tcagggatgc tgtgtggtgt   3360

ccatctgaac cccctgcata cgcgtagcta atgtgatctc cccactttca cataagatgg   3420

tggccctgcc ttcagggaat gtgggagcca ggtgggagcc ttcccggata tttaagctag   3480

aagattctac agggagattc tccttggatc aatatatgtc tctcagtcaa agatgtaaaa   3540

gcacttttgc cttaaaaaga atgttctgtt tctaaataga gtcaacgttg tcctcctcat   3600

tggaattcac tatgagtcag aatcattaga ctgacttttt tttttccata gtaatagtat   3660

tttgcagagt ctcacagagc tgcagatctt ttgttcatct tgcagagtta acaagtctga   3720

tcctgttagt ccagatttct taaatttggc caagttataa taggagcagt agcttgagac   3780

ccgaagtcag gaaactttga caatggattt ttttttttaa tccagagact tgtactggaa   3840

tttgccttac cctgtcagct catggactta aggtttcatc ccgctttatg agtgcttctg   3900

aatccaagtc attgttacct gaatttgcaa attaagttgt gatattcgtg actgttaaat   3960

tcctgtaatt agattaacct ctttgcttgc ttgtttgttt tctctcctat tttagcttaa   4020

agtatcagtg gttgagaaga gcttttcgga cctgttacta ccccaagctg tgtaatatac   4080

ttgtataaca gaaatacctt ctatacaaac ctttttttct acttttagat agaaatgtct   4140

actttttcag cagttctgtg aattaaagag cagagtgact gtgggtctgg aatggctggt   4200

gtacttggga atgtactatc aggattttac agcaatgctg ggaaatgaca gggaaaatga   4260

caggaatgaa tctcaccaga ttttttatgt actcagcaga gccttgagtt acggtgttta   4320

ttttccaatc aagtgaagat atctcctact tctcctactg gaacatctca gcttctgcag   4380

tgaagaaaaa ttcctgtgat agttcagttc tttagttttt ctatttgaaa aaaaaaaatc   4440

atttaaatga tcctttgttc acggctctcc ttaatgactg agtgaacagt tcctatctgt   4500

atatttgact aaaccttttc ctaagctatc tctcatggtt cctatgtttt tttatcataa   4560

ttaaaagcaa aaccatctgg atcacctaac agtcagaggt cagtatctca gcgtgtgaat   4620

tatagaggaa atacagagag aacctcttcc acttttactt ttcgtccaaa taaaatgcat   4680

ggtgtaccag aagttgaaga tcgggttgag gattggggct agctcgatga cactaaggcc   4740

ccaacatcgc gggacctgct gtggcgcgga ttcttaggaa cgctgttcta gccggccccc   4800

tctccagggg tcgccgtggc cggcattatt tcctagttct tcttgtaacc ctgaggtgcc   4860

agcgcgggga gtgaggaggg gtcagggggc taaggatgca acctctgacg ttctgcgcct   4920

tcctaggaga gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt aaaataccag   4980

ctctacaaga agctaggctc tgtgacggca tagttttcag tagctttatc acaatattca   5040

caatggagaa ttatatgaca tggtagcaga aataggccct tttatgtgtt gcttctattt   5100

tacctcaaat tgtagatata gggtaatcaa taaaatccat ccatgccttt cacacactaa   5160

gt                                                                  5162


<210>  5053
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  5053

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala 



<210>  5054
<211>  4924
<212>  DNA
<213>  Homo sapiens

<400>  5054
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agctcaagct cttggactca ccgaggcagt aaaagtacca tatcctgtgt   1920

ttgaatcaaa cccggagttc ttgtatgtgg aaggcttgcc agaggggatt cccttccgaa   1980

gccctacctg gtttggaatt ccacgacttg aaaggatcgt ccgcgggagt aataaaatca   2040

agttcgttgt taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta   2100

aaataaacac taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa   2160

aggttcctga aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag   2220

ctgttcgaac cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag   2280

agttttcctt tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc   2340

tcttcaatga gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg   2400

cgttatttga gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat   2460

tccgaagacc atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca   2520

aaattaagtt catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct   2580

cctctaagag ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag   2640

gtgttgaaga ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct   2700

cgaaagttga aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat   2760

ttggtgaagc tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta   2820

accctggctg tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct   2880

acctggaaat cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg   2940

tcattagacc atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag   3000

aaggccccgt gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag   3060

gtaaaaggac ctcttccctc ctagggtaaa tcagcttctg tgtcagggat gctgtgtggt   3120

gtccatctga accccctgca tacgcgtagc taatgtgatc tccccacttt cacataagat   3180

ggtggccctg ccttcaggga atgtgggagc caggtgggag ccttcccgga tatttaagct   3240

agaagattct acagggagat tctccttgga tcaatatatg tctctcagtc aaagatgtaa   3300

aagcactttt gccttaaaaa gaatgttctg tttctaaata gagtcaacgt tgtcctcctc   3360

attggaattc actatgagtc agaatcatta gactgacttt tttttttcca tagtaatagt   3420

attttgcaga gtctcacaga gctgcagatc ttttgttcat cttgcagagt taacaagtct   3480

gatcctgtta gtccagattt cttaaatttg gccaagttat aataggagca gtagcttgag   3540

acccgaagtc aggaaacttt gacaatggat tttttttttt aatccagaga cttgtactgg   3600

aatttgcctt accctgtcag ctcatggact taaggtttca tcccgcttta tgagtgcttc   3660

tgaatccaag tcattgttac ctgaatttgc aaattaagtt gtgatattcg tgactgttaa   3720

attcctgtaa ttagattaac ctctttgctt gcttgtttgt tttctctcct attttagctt   3780

aaagtatcag tggttgagaa gagcttttcg gacctgttac taccccaagc tgtgtaatat   3840

acttgtataa cagaaatacc ttctatacaa accttttttt ctacttttag atagaaatgt   3900

ctactttttc agcagttctg tgaattaaag agcagagtga ctgtgggtct ggaatggctg   3960

gtgtacttgg gaatgtacta tcaggatttt acagcaatgc tgggaaatga cagggaaaat   4020

gacaggaatg aatctcacca gattttttat gtactcagca gagccttgag ttacggtgtt   4080

tattttccaa tcaagtgaag atatctccta cttctcctac tggaacatct cagcttctgc   4140

agtgaagaaa aattcctgtg atagttcagt tctttagttt ttctatttga aaaaaaaaaa   4200

tcatttaaat gatcctttgt tcacggctct ccttaatgac tgagtgaaca gttcctatct   4260

gtatatttga ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt tttttatcat   4320

aattaaaagc aaaaccatct ggatcaccta acagtcagag gtcagtatct cagcgtgtga   4380

attatagagg aaatacagag agaacctctt ccacttttac ttttcgtcca aataaaatgc   4440

atggtgtacc agaagttgaa gatcgggttg aggattgggg ctagctcgat gacactaagg   4500

ccccaacatc gcgggacctg ctgtggcgcg gattcttagg aacgctgttc tagccggccc   4560

cctctccagg ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa ccctgaggtg   4620

ccagcgcggg gagtgaggag gggtcagggg gctaaggatg caacctctga cgttctgcgc   4680

cttcctagga gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc   4740

agctctacaa gaagctaggc tctgtgacgg catagttttc agtagcttta tcacaatatt   4800

cacaatggag aattatatga catggtagca gaaataggcc cttttatgtg ttgcttctat   4860

tttacctcaa attgtagata tagggtaatc aataaaatcc atccatgcct ttcacacact   4920

aagt                                                                4924


<210>  5055
<211>  943
<212>  PRT
<213>  Homo sapiens

<400>  5055

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu 
    530                 535                 540


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
545                 550                 555                 560


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
                565                 570                 575


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
            580                 585                 590


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
        595                 600                 605


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
    610                 615                 620


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
625                 630                 635                 640


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
                645                 650                 655


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
            660                 665                 670


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
        675                 680                 685


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
    690                 695                 700


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
705                 710                 715                 720


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
                725                 730                 735


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
            740                 745                 750


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
        755                 760                 765


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
    770                 775                 780


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
785                 790                 795                 800


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
                805                 810                 815


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
            820                 825                 830


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
        835                 840                 845


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
    850                 855                 860


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
865                 870                 875                 880


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
                885                 890                 895


Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser 
            900                 905                 910


Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu 
        915                 920                 925


Glu Val Pro Ala Thr Glu Gly Lys Arg Thr Ser Ser Leu Leu Gly 
    930                 935                 940


<210>  5056
<211>  3866
<212>  DNA
<213>  Homo sapiens

<400>  5056
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040

taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2100

ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2160

ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2220

ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2280

ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2340

atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2400

agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2460

agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2520

tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2580

ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2640

tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2700

ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2760

atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2820

ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2880

tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   2940

ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   3000

tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3060

ttatcaaatt cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg   3120

atcagagtga gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag   3180

ttccagccac agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag   3240

accccacgtg gtagacctct tccctcctag gcaaaaccat ctggatcacc taacagtcag   3300

aggtcagtat ctcagcgtgt gaattataga ggaaatacag agagaacctc ttccactttt   3360

acttttcgtc caaataaaat gcatggtgta ccagaagttg aagatcgggt tgaggattgg   3420

ggctagctcg atgacactaa ggccccaaca tcgcgggacc tgctgtggcg cggattctta   3480

ggaacgctgt tctagccggc cccctctcca ggggtcgccg tggccggcat tatttcctag   3540

ttcttcttgt aaccctgagg tgccagcgcg gggagtgagg aggggtcagg gggctaagga   3600

tgcaacctct gacgttctgc gccttcctag gagagtctta catgtgttga gatttcacaa   3660

gcaatgcgag ttgtaaaata ccagctctac aagaagctag gctctgtgac ggcatagttt   3720

tcagtagctt tatcacaata ttcacaatgg agaattatat gacatggtag cagaaatagg   3780

cccttttatg tgttgcttct attttacctc aaattgtaga tatagggtaa tcaataaaat   3840

ccatccatgc ctttcacaca ctaagt                                        3866


<210>  5057
<211>  998
<212>  PRT
<213>  Homo sapiens

<400>  5057

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr 
        595                 600                 605


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe 
    610                 615                 620


Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys 
625                 630                 635                 640


Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly 
                645                 650                 655


Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro 
            660                 665                 670


Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val 
        675                 680                 685


Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro 
    690                 695                 700


Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu 
705                 710                 715                 720


Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys 
                725                 730                 735


Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys 
            740                 745                 750


Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp 
        755                 760                 765


Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser 
    770                 775                 780


Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys 
785                 790                 795                 800


Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys 
                805                 810                 815


Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro 
            820                 825                 830


Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln 
        835                 840                 845


Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys 
    850                 855                 860


Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe 
865                 870                 875                 880


Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys 
                885                 890                 895


Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly 
            900                 905                 910


Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg 
        915                 920                 925


Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe 
    930                 935                 940


Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu 
945                 950                 955                 960


Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro 
                965                 970                 975


Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln 
            980                 985                 990


Glu Pro Asp Pro Thr Trp 
        995


<210>  5058
<211>  4869
<212>  DNA
<213>  Homo sapiens

<400>  5058
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1080

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1140

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1200

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1260

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1320

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1380

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1440

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1500

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1560

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1620

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1680

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1740

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1800

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1860

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1920

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   1980

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2040

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2100

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2160

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2220

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2280

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2340

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2400

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2460

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2520

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2580

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2640

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2700

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2760

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2820

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   2880

cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg atcagagtga   2940

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   3000

agaaggtaaa aggacctctt ccctcctagg gtaaatcagc ttctgtgtca gggatgctgt   3060

gtggtgtcca tctgaacccc ctgcatacgc gtagctaatg tgatctcccc actttcacat   3120

aagatggtgg ccctgccttc agggaatgtg ggagccaggt gggagccttc ccggatattt   3180

aagctagaag attctacagg gagattctcc ttggatcaat atatgtctct cagtcaaaga   3240

tgtaaaagca cttttgcctt aaaaagaatg ttctgtttct aaatagagtc aacgttgtcc   3300

tcctcattgg aattcactat gagtcagaat cattagactg actttttttt ttccatagta   3360

atagtatttt gcagagtctc acagagctgc agatcttttg ttcatcttgc agagttaaca   3420

agtctgatcc tgttagtcca gatttcttaa atttggccaa gttataatag gagcagtagc   3480

ttgagacccg aagtcaggaa actttgacaa tggatttttt tttttaatcc agagacttgt   3540

actggaattt gccttaccct gtcagctcat ggacttaagg tttcatcccg ctttatgagt   3600

gcttctgaat ccaagtcatt gttacctgaa tttgcaaatt aagttgtgat attcgtgact   3660

gttaaattcc tgtaattaga ttaacctctt tgcttgcttg tttgttttct ctcctatttt   3720

agcttaaagt atcagtggtt gagaagagct tttcggacct gttactaccc caagctgtgt   3780

aatatacttg tataacagaa ataccttcta tacaaacctt tttttctact tttagataga   3840

aatgtctact ttttcagcag ttctgtgaat taaagagcag agtgactgtg ggtctggaat   3900

ggctggtgta cttgggaatg tactatcagg attttacagc aatgctggga aatgacaggg   3960

aaaatgacag gaatgaatct caccagattt tttatgtact cagcagagcc ttgagttacg   4020

gtgtttattt tccaatcaag tgaagatatc tcctacttct cctactggaa catctcagct   4080

tctgcagtga agaaaaattc ctgtgatagt tcagttcttt agtttttcta tttgaaaaaa   4140

aaaaatcatt taaatgatcc tttgttcacg gctctcctta atgactgagt gaacagttcc   4200

tatctgtata tttgactaaa ccttttccta agctatctct catggttcct atgttttttt   4260

atcataatta aaagcaaaac catctggatc acctaacagt cagaggtcag tatctcagcg   4320

tgtgaattat agaggaaata cagagagaac ctcttccact tttacttttc gtccaaataa   4380

aatgcatggt gtaccagaag ttgaagatcg ggttgaggat tggggctagc tcgatgacac   4440

taaggcccca acatcgcggg acctgctgtg gcgcggattc ttaggaacgc tgttctagcc   4500

ggccccctct ccaggggtcg ccgtggccgg cattatttcc tagttcttct tgtaaccctg   4560

aggtgccagc gcggggagtg aggaggggtc agggggctaa ggatgcaacc tctgacgttc   4620

tgcgccttcc taggagagtc ttacatgtgt tgagatttca caagcaatgc gagttgtaaa   4680

ataccagctc tacaagaagc taggctctgt gacggcatag ttttcagtag ctttatcaca   4740

atattcacaa tggagaatta tatgacatgg tagcagaaat aggccctttt atgtgttgct   4800

tctattttac ctcaaattgt agatataggg taatcaataa aatccatcca tgcctttcac   4860

acactaagt                                                           4869


<210>  5059
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  5059

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
                565                 570                 575


Ser Ser Leu Leu Lys Asn Leu Asn 
            580


<210>  5060
<211>  4242
<212>  DNA
<213>  Homo sapiens

<400>  5060
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1080

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1140

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1200

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1260

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1320

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1380

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1440

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1500

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1560

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1620

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1680

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1740

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1800

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1860

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1920

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   1980

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2040

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2100

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2160

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2220

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2280

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2340

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2400

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2460

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2520

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2580

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2640

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2700

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2760

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2820

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   2880

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   2940

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3000

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3060

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3120

ttcacggtca ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt   3180

gagtcagaag gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc   3240

acagaagaaa taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg   3300

tggtagacct cttccctcct aggcttaaag tatcagtggt tgagaagagc ttttcggacc   3360

tgttactacc ccaagctgta gccttgagtt acggtgttta ttttccaatc aagtgaagat   3420

atctcctact tctcctactg gaacatctca gcttctgcag tgaagaaaaa ttcctgtgat   3480

agttcagttc tttagttttt ctatttgaaa aaaaaaaatc atttaaatga tcctttgttc   3540

acggctctcc ttaatgactg agtgaacagt tcctatctgt atatttgact aaaccttttc   3600

ctaagctatc tctcatggtt cctatgtttt tttatcataa ttaaaagcaa aaccatctgg   3660

atcacctaac agtcagaggt cagtatctca gcgtgtgaat tatagaggaa atacagagag   3720

aacctcttcc acttttactt ttcgtccaaa taaaatgcat ggtgtaccag aagttgaaga   3780

tcgggttgag gattggggct agctcgatga cactaaggcc ccaacatcgc gggacctgct   3840

gtggcgcgga ttcttaggaa cgctgttcta gccggccccc tctccagggg tcgccgtggc   3900

cggcattatt tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga gtgaggaggg   3960

gtcagggggc taaggatgca acctctgacg ttctgcgcct tcctaggaga gtcttacatg   4020

tgttgagatt tcacaagcaa tgcgagttgt aaaataccag ctctacaaga agctaggctc   4080

tgtgacggca tagttttcag tagctttatc acaatattca caatggagaa ttatatgaca   4140

tggtagcaga aataggccct tttatgtgtt gcttctattt tacctcaaat tgtagatata   4200

gggtaatcaa taaaatccat ccatgccttt cacacactaa gt                      4242


<210>  5061
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  5061

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala 



<210>  5062
<211>  4213
<212>  DNA
<213>  Homo sapiens

<400>  5062
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag    960

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1020

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1080

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1140

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1200

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1260

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1320

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1380

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1440

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1500

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1560

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1620

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1680

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1740

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1800

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1860

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1920

aatcaaaccc ggagttcttg aaaggatcgt ccgcgggagt aataaaatca agttcgttgt   1980

taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta aaataaacac   2040

taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa aggttcctga   2100

aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag ctgttcgaac   2160

cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag agttttcctt   2220

tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc tcttcaatga   2280

gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg cgttatttga   2340

gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat tccgaagacc   2400

atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca aaattaagtt   2460

catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct cctctaagag   2520

ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag gtgttgaaga   2580

ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct cgaaagttga   2640

aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat ttggtgaagc   2700

tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta accctggctg   2760

tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct acctggaaat   2820

cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg tcattagacc   2880

atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag aaggccccgt   2940

gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag aaataaaaga   3000

gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga cctcttccct   3060

cctaggctta aagtatcagt ggttgagaag agcttttcgg acctgttact accccaagct   3120

gtgtaatata cttgtataac agaaatacct tctatacaaa cctttttttc tacttttaga   3180

tagaaatgtc tactttttca gcagttctgt gaattaaaga gcagagtgac tgtgggtctg   3240

gaatggctgg tgtacttggg aatgtactat caggatttta cagcaatgct gggaaatgac   3300

agggaaaatg acaggaatga atctcaccag attttttatg tactcagcag agccttgagt   3360

tacggtgttt attttccaat caagtgaaga tatctcctac ttctcctact ggaacatctc   3420

agcttctgca gtgaagaaaa attcctgtga tagttcagtt ctttagtttt tctatttgaa   3480

aaaaaaaaat catttaaatg atcctttgtt cacggctctc cttaatgact gagtgaacag   3540

ttcctatctg tatatttgac taaacctttt cctaagctat ctctcatggt tcctatgttt   3600

ttttatcata attaaaagca aaaccatctg gatcacctaa cagtcagagg tcagtatctc   3660

agcgtgtgaa ttatagagga aatacagaga gaacctcttc cacttttact tttcgtccaa   3720

ataaaatgca tggtgtacca gaagttgaag atcgggttga ggattggggc tagctcgatg   3780

acactaaggc cccaacatcg cgggacctgc tgtggcgcgg attcttagga acgctgttct   3840

agccggcccc ctctccaggg gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac   3900

cctgaggtgc cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc aacctctgac   3960

gttctgcgcc ttcctaggag agtcttacat gtgttgagat ttcacaagca atgcgagttg   4020

taaaatacca gctctacaag aagctaggct ctgtgacggc atagttttca gtagctttat   4080

cacaatattc acaatggaga attatatgac atggtagcag aaataggccc ttttatgtgt   4140

tgcttctatt ttacctcaaa ttgtagatat agggtaatca ataaaatcca tccatgcctt   4200

tcacacacta agt                                                      4213


<210>  5063
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  5063

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys 
                565                 570                 575


Asn Leu Asn 



<210>  5064
<211>  4007
<212>  DNA
<213>  Homo sapiens

<400>  5064
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1080

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1140

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1200

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1260

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1320

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1380

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1440

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1500

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1560

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1620

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1680

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1740

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1800

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1860

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1920

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   1980

taccatatcc tgtgtttgaa tcaaacccgg agttcttgaa aggatcgtcc gcgggagtaa   2040

taaaatcaag ttcgttgtta aaaaacctga actagttatt tcctacttgc ctcctgggat   2100

ggctagtaaa ataaacacta aagctttgca gtcccccaaa agaccacgaa gtcctgggag   2160

taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc cctaataaca acaatcctca   2220

aacctcagct gttcgaaccc cgacccagac taacggttct aacgttccct tcaagccacg   2280

agggagagag ttttcctttg aggcctggaa tgccaaaatc acggacctaa aacagaaagt   2340

tgaaaatctc ttcaatgaga aatgtgggga agctcttggc cttaaacaag ctgtgaaggt   2400

gccgttcgcg ttatttgagt ctttcccgga agacttttat gtggaaggct tacctgaggg   2460

tgtgccattc cgaagaccat cgacttttgg cattccgagg ctggagaaga tactcagaaa   2520

caaagccaaa attaagttca tcattaaaaa gcccgaaatg tttgagacgg cgattaagga   2580

gagcacctcc tctaagagcc ctcccagaaa aataaattca tcacccaatg ttaatactac   2640

tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca attccagatg atgataatga   2700

aagactctcg aaagttgaaa aagctagaca gctaagagaa caagtgaatg acctctttag   2760

tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg aaagttccct acaggaaaat   2820

cacaattaac cctggctgtg tggtggttga tggcatgccc ccgggggtgt ccttcaaagc   2880

ccccagctac ctggaaatca gctccatgag aaggatctta gactctgccg agtttatcaa   2940

attcacggtc attagaccat ttccaggact tgtgattaat aaccagctgg ttgatcagag   3000

tgagtcagaa ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc   3060

cacagaagaa ataaaagaga ctgatggaag ctctcagatc aagcaagaac cagaccccac   3120

gtggtagacc tcttccctcc taggagcctt gagttacggt gtttattttc caatcaagtg   3180

aagatatctc ctacttctcc tactggaaca tctcagcttc tgcagtgaag aaaaattcct   3240

gtgatagttc agttctttag tttttctatt tgaaaaaaaa aaatcattta aatgatcctt   3300

tgttcacggc tctccttaat gactgagtga acagttccta tctgtatatt tgactaaacc   3360

ttttcctaag ctatctctca tggttcctat gtttttttat cataattaaa agcaaaacca   3420

tctggatcac ctaacagtca gaggtcagta tctcagcgtg tgaattatag aggaaataca   3480

gagagaacct cttccacttt tacttttcgt ccaaataaaa tgcatggtgt accagaagtt   3540

gaagatcggg ttgaggattg gggctagctc gatgacacta aggccccaac atcgcgggac   3600

ctgctgtggc gcggattctt aggaacgctg ttctagccgg ccccctctcc aggggtcgcc   3660

gtggccggca ttatttccta gttcttcttg taaccctgag gtgccagcgc ggggagtgag   3720

gaggggtcag ggggctaagg atgcaacctc tgacgttctg cgccttccta ggagagtctt   3780

acatgtgttg agatttcaca agcaatgcga gttgtaaaat accagctcta caagaagcta   3840

ggctctgtga cggcatagtt ttcagtagct ttatcacaat attcacaatg gagaattata   3900

tgacatggta gcagaaatag gcccttttat gtgttgcttc tattttacct caaattgtag   3960

atatagggta atcaataaaa tccatccatg cctttcacac actaagt                 4007


<210>  5065
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  5065

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala 
            580                 585                 590


Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600                 605


<210>  5066
<211>  4407
<212>  DNA
<213>  Homo sapiens

<400>  5066
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1080

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1140

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1200

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1260

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1320

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1380

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1440

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1500

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1560

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1620

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1680

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1740

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1800

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1860

aagagatttt taatttgaaa tttgcttaga tttgttgaca gcggtttcct ggagtgctgt   1920

cttgagaacg attctgagga ggctcagcaa gaaagagtgt ttcagttgat tgggtgtgtc   1980

tgtcatggag aaggaactca agctcttgga ctcaccgagg cagtaaaagt accatatcct   2040

gtgtttgaat caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc   2100

cgaagcccta cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa   2160

atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct   2220

agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat   2280

tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc   2340

tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg   2400

agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa   2460

aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg   2520

ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg   2580

ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa   2640

gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc   2700

acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca   2760

tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga   2820

ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg   2880

aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca   2940

attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt caaagccccc   3000

agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc   3060

acggtcatta gaccatttcc aggacttgtg attaataacc agctggttga tcagagtgag   3120

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   3180

gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga ccccacgtgg   3240

tagacctctt ccctcctagg cttaaagtat cagtggttga gaagagcttt tcggacctgt   3300

tactacccca agctgtgtaa tatacttgta taacagaaat accttctata caaacctttt   3360

tttctacttt tagatagaaa tgtctacttt ttcagcagtt ctgtgaatta aagagcagag   3420

tgactgtggg tctggaatgg ctggtgtact tgggaatgta ctatcaggat tttacagcaa   3480

tgctgggaaa tgacagggaa aatgacagga atgaatctca ccagattttt tatgtactca   3540

gcagagcctt gagttacggt gtttattttc caatcaagtg aagatatctc ctacttctcc   3600

tactggaaca tctcagcttc tgcagtgaag aaaaattcct gtgatagttc agttctttag   3660

tttttctatt tgaaaaaaaa aaatcattta aatgatcctt tgttcacggc tctccttaat   3720

gactgagtga acagttccta tctgtatatt tgactaaacc ttttcctaag ctatctctca   3780

tggttcctat gtttttttat cataattaaa agcaaaacca tctggatcac ctaacagtca   3840

gaggtcagta tctcagcgtg tgaattatag aggaaataca gagagaacct cttccacttt   3900

tacttttcgt ccaaataaaa tgcatggtgt accagaagtt gaagatcggg ttgaggattg   3960

gggctagctc gatgacacta aggccccaac atcgcgggac ctgctgtggc gcggattctt   4020

aggaacgctg ttctagccgg ccccctctcc aggggtcgcc gtggccggca ttatttccta   4080

gttcttcttg taaccctgag gtgccagcgc ggggagtgag gaggggtcag ggggctaagg   4140

atgcaacctc tgacgttctg cgccttccta ggagagtctt acatgtgttg agatttcaca   4200

agcaatgcga gttgtaaaat accagctcta caagaagcta ggctctgtga cggcatagtt   4260

ttcagtagct ttatcacaat attcacaatg gagaattata tgacatggta gcagaaatag   4320

gcccttttat gtgttgcttc tattttacct caaattgtag atatagggta atcaataaaa   4380

tccatccatg cctttcacac actaagt                                       4407


<210>  5067
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  5067

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  5068
<211>  4972
<212>  DNA
<213>  Homo sapiens

<400>  5068
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag    960

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1020

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1080

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1140

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1200

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1260

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1320

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1380

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1440

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1500

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1560

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1620

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1680

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1740

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1800

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1860

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1920

aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc   1980

ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt   2040

tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa   2100

taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg   2160

ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg   2220

ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga gggagagagt   2280

tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct   2340

tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt   2400

tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc   2460

gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa   2520

ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct   2580

ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg   2640

ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga   2700

aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg   2760

gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc   2820

ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc   2880

tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca   2940

ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt gagtcagaag   3000

gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc acagaagaaa   3060

taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg tggtagacct   3120

cttccctcct agggtaaatc agcttctgtg tcagggatgc tgtgtggtgt ccatctgaac   3180

cccctgcata cgcgtagcta atgtgatctc cccactttca cataagatgg tggccctgcc   3240

ttcagggaat gtgggagcca ggtgggagcc ttcccggata tttaagctag aagattctac   3300

agggagattc tccttggatc aatatatgtc tctcagtcaa agatgtaaaa gcacttttgc   3360

cttaaaaaga atgttctgtt tctaaataga gtcaacgttg tcctcctcat tggaattcac   3420

tatgagtcag aatcattaga ctgacttttt tttttccata gtaatagtat tttgcagagt   3480

ctcacagagc tgcagatctt ttgttcatct tgcagagtta acaagtctga tcctgttagt   3540

ccagatttct taaatttggc caagttataa taggagcagt agcttgagac ccgaagtcag   3600

gaaactttga caatggattt ttttttttaa tccagagact tgtactggaa tttgccttac   3660

cctgtcagct catggactta aggtttcatc ccgctttatg agtgcttctg aatccaagtc   3720

attgttacct gaatttgcaa attaagttgt gatattcgtg actgttaaat tcctgtaatt   3780

agattaacct ctttgcttgc ttgtttgttt tctctcctat tttagcttaa agtatcagtg   3840

gttgagaaga gcttttcgga cctgttacta ccccaagctg tgtaatatac ttgtataaca   3900

gaaatacctt ctatacaaac ctttttttct acttttagat agaaatgtct actttttcag   3960

cagttctgtg aattaaagag cagagtgact gtgggtctgg aatggctggt gtacttggga   4020

atgtactatc aggattttac agcaatgctg ggaaatgaca gggaaaatga caggaatgaa   4080

tctcaccaga ttttttatgt actcagcaga gccttgagtt acggtgttta ttttccaatc   4140

aagtgaagat atctcctact tctcctactg gaacatctca gcttctgcag tgaagaaaaa   4200

ttcctgtgat agttcagttc tttagttttt ctatttgaaa aaaaaaaatc atttaaatga   4260

tcctttgttc acggctctcc ttaatgactg agtgaacagt tcctatctgt atatttgact   4320

aaaccttttc ctaagctatc tctcatggtt cctatgtttt tttatcataa ttaaaagcaa   4380

aaccatctgg atcacctaac agtcagaggt cagtatctca gcgtgtgaat tatagaggaa   4440

atacagagag aacctcttcc acttttactt ttcgtccaaa taaaatgcat ggtgtaccag   4500

aagttgaaga tcgggttgag gattggggct agctcgatga cactaaggcc ccaacatcgc   4560

gggacctgct gtggcgcgga ttcttaggaa cgctgttcta gccggccccc tctccagggg   4620

tcgccgtggc cggcattatt tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga   4680

gtgaggaggg gtcagggggc taaggatgca acctctgacg ttctgcgcct tcctaggaga   4740

gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt aaaataccag ctctacaaga   4800

agctaggctc tgtgacggca tagttttcag tagctttatc acaatattca caatggagaa   4860

ttatatgaca tggtagcaga aataggccct tttatgtgtt gcttctattt tacctcaaat   4920

tgtagatata gggtaatcaa taaaatccat ccatgccttt cacacactaa gt           4972


<210>  5069
<211>  952
<212>  PRT
<213>  Homo sapiens

<400>  5069

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr 
                565                 570                 575


Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys 
            580                 585                 590


Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro 
        595                 600                 605


Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys 
    610                 615                 620


Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val 
625                 630                 635                 640


Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg 
                645                 650                 655


Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly 
            660                 665                 670


Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys 
        675                 680                 685


Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly 
    690                 695                 700


Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro 
705                 710                 715                 720


Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg 
                725                 730                 735


Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys 
            740                 745                 750


Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala 
        755                 760                 765


Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser 
    770                 775                 780


Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile 
785                 790                 795                 800


Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val 
                805                 810                 815


Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg 
            820                 825                 830


Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr 
        835                 840                 845


Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro 
    850                 855                 860


Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met 
865                 870                 875                 880


Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
                885                 890                 895


Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu 
            900                 905                 910


Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu 
        915                 920                 925


Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile 
    930                 935                 940


Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  5070
<211>  7799
<212>  DNA
<213>  Homo sapiens

<400>  5070
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   1980

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   2040

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2100

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2160

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2220

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2280

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2340

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2400

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2460

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2520

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2580

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2640

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2700

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2760

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2820

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2880

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   2940

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   3000

cggtcattag gtaagtgaga gtttcctgct tagtcacagg agcgaatctg gagctcatga   3060

ggctgactct tctaaaatgc agccacaggt agtcatcgaa tccggcttcc tatgctgtgc   3120

aatcaacaaa tcaaaataac ttgtgtcatc attagaatgt cagatgtgct tctacgaact   3180

aagctgactc ttttaattct ttggcaaagg gttggcaaac taggactgtt tgccaaattc   3240

aggctgcctc ctatttttag agtcttcctg aaacacagct acacccgtat tatccatggc   3300

tgctttcctg tcacagtgag taagtagctg ggactgagaa ggcatggcct ccaaagtcta   3360

aaatatttac tctctagcac tttgtagaaa aaccttagct aggcacagtg gctaacgcct   3420

gtaatcccag cattttggga ggccaaggca ggcagatcac ctgaggtcag gagttccaga   3480

ccagcctggc caacatggtg aaatcccatc tctacaaaaa taaaacagtt agctgggcat   3540

gatggcgggt gcctgtaatc ccagctactc gggaggctga ggcaggatag tcgcttgaac   3600

ccaggaggtg gaggttgcaa tgagccaaga tcatgccact gcactccagc ctggacgaca   3660

gagtgagact ccatcacaag aaaaaaagaa ctttgtcaac ctctgtctta gggcgccttg   3720

tcacaggctt cgggtcagac ggattcaacc ttgcatcagc catttgttag ccaggtcact   3780

ctgttctttg tctgtaaatg agattgatcg ttgttcccac tgagagtgtc agctccttcc   3840

cgtagagcag gcatgatgat tgtactcacc tctgacacca ttgtgagtgc cacattcctt   3900

cccacgtcct tgtcactgta agagatgccc acctgagcac caaccccagg ttatcttccc   3960

ctttgtcttc cagcccccca gaaacagcta cgactcaacc tacccaatca tttcatcatc   4020

agattgccac tgtctctagt tcaggtctct tgggactggc actcagaaat ctcataataa   4080

atcctcttga ggcttctcat acactcgtct tcttccaatc ttctttccct caaaatctca   4140

tattttggtt ccacttcacc caccgtcatt ctccatatca ctcccaggag ttaggcaaaa   4200

agccccttcc gttcttccgt atgttaaact tagaatcact ctgttccctg ctctgcgttt   4260

ctattttttg tttttcctcc atttactagt agcttaacac tttctaacag tgttcttatt   4320

attgatacgt atctatctct tccataagct tataaggtca cggataatac ttctcattgt   4380

agtacgtaaa tgacgtgggc tagatatgag ttgaataaac agttatacct gtaaattctt   4440

acagagtgaa aataaattgt tatactttac aatttgtttc tctctttaga ccatttccag   4500

gacttgtgat taataaccgt gagtattttg tgaagtgttt tgtttttgtt ttttcctggg   4560

gtctgacgtg tgtgcgtgtg agtgtgtata catgcttaac gtatatcacg ttacttcacc   4620

tatgtcagta accaggccaa atacttgttt tagccctcag taaaaacacc aggcacttcc   4680

tagttgtaaa attattcaag cttcttaact tcctatcctc gatgcactta atcataaaat   4740

ggtaataata gcaccgattt tgggggagtc gttccagtag atggaaagca tctggaacag   4800

gtgtcagcaa gctcctgccg acgtgtatgc ataaagtttt attgaaacca ccatcgtgtc   4860

catttgttta tggcagaact gagagatggc agcagcaagt gtgtgcctgc aaaacctaaa   4920

atatttacta attggctctg caagaaaaga gtttgcatcc ccctaaccta gaacagtgtc   4980

tagcctctag tatgtgttta gcctacagta tgtgctcagc gaatacaatc tatatttatt   5040

actgctttta tgactgttat aattactgtg cttggatttc gttacaaagt aagtcacaat   5100

gtgcctgctt ctgttagtat ttcagcacag tgcctggcac acatggggct ctcaaatatt   5160

gctgagcgag tgaacaaatg tcctttcaat tccttaacgt tgatgtcatt ttcaatagta   5220

ttttgagcca aacttaattt tgcgagtgtg ttttgttttc ttaactttat tattaaaaat   5280

gtataaaagt gaggccaggc gtggtggctc acgcctgtaa tcccagcagt ttgggaggct   5340

gaggcaggcg gatcagttga ggttgggagt tggagaccag cccgtccaac atggtgaaag   5400

cctgtctcta ctaaaaatac aaaaatcagc tgggtgtggt ggcgcgtgcc tgtaatccca   5460

gctactcagg aggctgaggc aggagagttg cttgaatcct agaggtggag gttgcagtga   5520

gctgagatcg tgccattgca ctccagcctg ggcaacaaga gcaaaactct gtcccaataa   5580

ataaataaat aaaatgttct cttttgttcc tgttcttgtg cggtagtgtg gtatagagtt   5640

ttatggtaat tactgtgaat tagtgattct gagggacata tcagaactct gaggtttgtt   5700

tccttctcat cttgagggaa acagcaaatg tatgttaaaa tgcttttcca agggaacaac   5760

acatccttac attatttaaa ccaatctgct tcattttcag agctggttga tcagagtgag   5820

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   5880

gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga ccccacgtgg   5940

tagacctctt ccctcctagg gtaaatcagc ttctgtgtca gggatgctgt gtggtgtcca   6000

tctgaacccc ctgcatacgc gtagctaatg tgatctcccc actttcacat aagatggtgg   6060

ccctgccttc agggaatgtg ggagccaggt gggagccttc ccggatattt aagctagaag   6120

attctacagg gagattctcc ttggatcaat atatgtctct cagtcaaaga tgtaaaagca   6180

cttttgcctt aaaaagaatg ttctgtttct aaatagagtc aacgttgtcc tcctcattgg   6240

aattcactat gagtcagaat cattagactg actttttttt ttccatagta atagtatttt   6300

gcagagtctc acagagctgc agatcttttg ttcatcttgc agagttaaca agtctgatcc   6360

tgttagtcca gatttcttaa atttggccaa gttataatag gagcagtagc ttgagacccg   6420

aagtcaggaa actttgacaa tggatttttt tttttaatcc agagacttgt actggaattt   6480

gccttaccct gtcagctcat ggacttaagg tttcatcccg ctttatgagt gcttctgaat   6540

ccaagtcatt gttacctgaa tttgcaaatt aagttgtgat attcgtgact gttaaattcc   6600

tgtaattaga ttaacctctt tgcttgcttg tttgttttct ctcctatttt agcttaaagt   6660

atcagtggtt gagaagagct tttcggacct gttactaccc caagctgtgt aatatacttg   6720

tataacagaa ataccttcta tacaaacctt tttttctact tttagataga aatgtctact   6780

ttttcagcag ttctgtgaat taaagagcag agtgactgtg ggtctggaat ggctggtgta   6840

cttgggaatg tactatcagg attttacagc aatgctggga aatgacaggg aaaatgacag   6900

gaatgaatct caccagattt tttatgtact cagcagagcc ttgagttacg gtgtttattt   6960

tccaatcaag tgaagatatc tcctacttct cctactggaa catctcagct tctgcagtga   7020

agaaaaattc ctgtgatagt tcagttcttt agtttttcta tttgaaaaaa aaaaatcatt   7080

taaatgatcc tttgttcacg gctctcctta atgactgagt gaacagttcc tatctgtata   7140

tttgactaaa ccttttccta agctatctct catggttcct atgttttttt atcataatta   7200

aaagcaaaac catctggatc acctaacagt cagaggtcag tatctcagcg tgtgaattat   7260

agaggaaata cagagagaac ctcttccact tttacttttc gtccaaataa aatgcatggt   7320

gtaccagaag ttgaagatcg ggttgaggat tggggctagc tcgatgacac taaggcccca   7380

acatcgcggg acctgctgtg gcgcggattc ttaggaacgc tgttctagcc ggccccctct   7440

ccaggggtcg ccgtggccgg cattatttcc tagttcttct tgtaaccctg aggtgccagc   7500

gcggggagtg aggaggggtc agggggctaa ggatgcaacc tctgacgttc tgcgccttcc   7560

taggagagtc ttacatgtgt tgagatttca caagcaatgc gagttgtaaa ataccagctc   7620

tacaagaagc taggctctgt gacggcatag ttttcagtag ctttatcaca atattcacaa   7680

tggagaatta tatgacatgg tagcagaaat aggccctttt atgtgttgct tctattttac   7740

ctcaaattgt agatataggg taatcaataa aatccatcca tgcctttcac acactaagt    7799


<210>  5071
<211>  918
<212>  PRT
<213>  Homo sapiens

<400>  5071

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala 
545                 550                 555                 560


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
                565                 570                 575


Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile 
            580                 585                 590


Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile 
        595                 600                 605


Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu 
    610                 615                 620


Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys 
625                 630                 635                 640


Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys 
                645                 650                 655


Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro 
            660                 665                 670


Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val 
        675                 680                 685


Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala 
    690                 695                 700


Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys 
705                 710                 715                 720


Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala 
                725                 730                 735


Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu 
            740                 745                 750


Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu 
        755                 760                 765


Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro 
    770                 775                 780


Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro 
785                 790                 795                 800


Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly 
                805                 810                 815


Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn 
            820                 825                 830


Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val 
        835                 840                 845


Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe 
    850                 855                 860


Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val 
865                 870                 875                 880


Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr 
                885                 890                 895


Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile 
            900                 905                 910


Lys Phe Thr Val Ile Arg 
        915


<210>  5072
<211>  7983
<212>  DNA
<213>  Homo sapiens

<400>  5072
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   2040

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2100

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2160

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2220

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2280

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2340

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2400

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2460

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2520

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2580

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2640

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2700

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2760

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2820

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2880

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   2940

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   3000

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3060

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3120

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3180

ttcacggtca ttaggtaagt gagagtttcc tgcttagtca caggagcgaa tctggagctc   3240

atgaggctga ctcttctaaa atgcagccac aggtagtcat cgaatccggc ttcctatgct   3300

gtgcaatcaa caaatcaaaa taacttgtgt catcattaga atgtcagatg tgcttctacg   3360

aactaagctg actcttttaa ttctttggca aagggttggc aaactaggac tgtttgccaa   3420

attcaggctg cctcctattt ttagagtctt cctgaaacac agctacaccc gtattatcca   3480

tggctgcttt cctgtcacag tgagtaagta gctgggactg agaaggcatg gcctccaaag   3540

tctaaaatat ttactctcta gcactttgta gaaaaacctt agctaggcac agtggctaac   3600

gcctgtaatc ccagcatttt gggaggccaa ggcaggcaga tcacctgagg tcaggagttc   3660

cagaccagcc tggccaacat ggtgaaatcc catctctaca aaaataaaac agttagctgg   3720

gcatgatggc gggtgcctgt aatcccagct actcgggagg ctgaggcagg atagtcgctt   3780

gaacccagga ggtggaggtt gcaatgagcc aagatcatgc cactgcactc cagcctggac   3840

gacagagtga gactccatca caagaaaaaa agaactttgt caacctctgt cttagggcgc   3900

cttgtcacag gcttcgggtc agacggattc aaccttgcat cagccatttg ttagccaggt   3960

cactctgttc tttgtctgta aatgagattg atcgttgttc ccactgagag tgtcagctcc   4020

ttcccgtaga gcaggcatga tgattgtact cacctctgac accattgtga gtgccacatt   4080

ccttcccacg tccttgtcac tgtaagagat gcccacctga gcaccaaccc caggttatct   4140

tcccctttgt cttccagccc cccagaaaca gctacgactc aacctaccca atcatttcat   4200

catcagattg ccactgtctc tagttcaggt ctcttgggac tggcactcag aaatctcata   4260

ataaatcctc ttgaggcttc tcatacactc gtcttcttcc aatcttcttt ccctcaaaat   4320

ctcatatttt ggttccactt cacccaccgt cattctccat atcactccca ggagttaggc   4380

aaaaagcccc ttccgttctt ccgtatgtta aacttagaat cactctgttc cctgctctgc   4440

gtttctattt tttgtttttc ctccatttac tagtagctta acactttcta acagtgttct   4500

tattattgat acgtatctat ctcttccata agcttataag gtcacggata atacttctca   4560

ttgtagtacg taaatgacgt gggctagata tgagttgaat aaacagttat acctgtaaat   4620

tcttacagag tgaaaataaa ttgttatact ttacaatttg tttctctctt tagaccattt   4680

ccaggacttg tgattaataa ccgtgagtat tttgtgaagt gttttgtttt tgttttttcc   4740

tggggtctga cgtgtgtgcg tgtgagtgtg tatacatgct taacgtatat cacgttactt   4800

cacctatgtc agtaaccagg ccaaatactt gttttagccc tcagtaaaaa caccaggcac   4860

ttcctagttg taaaattatt caagcttctt aacttcctat cctcgatgca cttaatcata   4920

aaatggtaat aatagcaccg attttggggg agtcgttcca gtagatggaa agcatctgga   4980

acaggtgtca gcaagctcct gccgacgtgt atgcataaag ttttattgaa accaccatcg   5040

tgtccatttg tttatggcag aactgagaga tggcagcagc aagtgtgtgc ctgcaaaacc   5100

taaaatattt actaattggc tctgcaagaa aagagtttgc atccccctaa cctagaacag   5160

tgtctagcct ctagtatgtg tttagcctac agtatgtgct cagcgaatac aatctatatt   5220

tattactgct tttatgactg ttataattac tgtgcttgga tttcgttaca aagtaagtca   5280

caatgtgcct gcttctgtta gtatttcagc acagtgcctg gcacacatgg ggctctcaaa   5340

tattgctgag cgagtgaaca aatgtccttt caattcctta acgttgatgt cattttcaat   5400

agtattttga gccaaactta attttgcgag tgtgttttgt tttcttaact ttattattaa   5460

aaatgtataa aagtgaggcc aggcgtggtg gctcacgcct gtaatcccag cagtttggga   5520

ggctgaggca ggcggatcag ttgaggttgg gagttggaga ccagcccgtc caacatggtg   5580

aaagcctgtc tctactaaaa atacaaaaat cagctgggtg tggtggcgcg tgcctgtaat   5640

cccagctact caggaggctg aggcaggaga gttgcttgaa tcctagaggt ggaggttgca   5700

gtgagctgag atcgtgccat tgcactccag cctgggcaac aagagcaaaa ctctgtccca   5760

ataaataaat aaataaaatg ttctcttttg ttcctgttct tgtgcggtag tgtggtatag   5820

agttttatgg taattactgt gaattagtga ttctgaggga catatcagaa ctctgaggtt   5880

tgtttccttc tcatcttgag ggaaacagca aatgtatgtt aaaatgcttt tccaagggaa   5940

caacacatcc ttacattatt taaaccaatc tgcttcattt tcagagctgg ttgatcagag   6000

tgagtcagaa ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc   6060

cacagaagaa ataaaagaga ctgatggaag ctctcagatc aagcaagaac cagaccccac   6120

gtggtagacc tcttccctcc tagggtaaat cagcttctgt gtcagggatg ctgtgtggtg   6180

tccatctgaa ccccctgcat acgcgtagct aatgtgatct ccccactttc acataagatg   6240

gtggccctgc cttcagggaa tgtgggagcc aggtgggagc cttcccggat atttaagcta   6300

gaagattcta cagggagatt ctccttggat caatatatgt ctctcagtca aagatgtaaa   6360

agcacttttg ccttaaaaag aatgttctgt ttctaaatag agtcaacgtt gtcctcctca   6420

ttggaattca ctatgagtca gaatcattag actgactttt ttttttccat agtaatagta   6480

ttttgcagag tctcacagag ctgcagatct tttgttcatc ttgcagagtt aacaagtctg   6540

atcctgttag tccagatttc ttaaatttgg ccaagttata ataggagcag tagcttgaga   6600

cccgaagtca ggaaactttg acaatggatt ttttttttta atccagagac ttgtactgga   6660

atttgcctta ccctgtcagc tcatggactt aaggtttcat cccgctttat gagtgcttct   6720

gaatccaagt cattgttacc tgaatttgca aattaagttg tgatattcgt gactgttaaa   6780

ttcctgtaat tagattaacc tctttgcttg cttgtttgtt ttctctccta ttttagctta   6840

aagtatcagt ggttgagaag agcttttcgg acctgttact accccaagct gtgtaatata   6900

cttgtataac agaaatacct tctatacaaa cctttttttc tacttttaga tagaaatgtc   6960

tactttttca gcagttctgt gaattaaaga gcagagtgac tgtgggtctg gaatggctgg   7020

tgtacttggg aatgtactat caggatttta cagcaatgct gggaaatgac agggaaaatg   7080

acaggaatga atctcaccag attttttatg tactcagcag agccttgagt tacggtgttt   7140

attttccaat caagtgaaga tatctcctac ttctcctact ggaacatctc agcttctgca   7200

gtgaagaaaa attcctgtga tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat   7260

catttaaatg atcctttgtt cacggctctc cttaatgact gagtgaacag ttcctatctg   7320

tatatttgac taaacctttt cctaagctat ctctcatggt tcctatgttt ttttatcata   7380

attaaaagca aaaccatctg gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa   7440

ttatagagga aatacagaga gaacctcttc cacttttact tttcgtccaa ataaaatgca   7500

tggtgtacca gaagttgaag atcgggttga ggattggggc tagctcgatg acactaaggc   7560

cccaacatcg cgggacctgc tgtggcgcgg attcttagga acgctgttct agccggcccc   7620

ctctccaggg gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac cctgaggtgc   7680

cagcgcgggg agtgaggagg ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc   7740

ttcctaggag agtcttacat gtgttgagat ttcacaagca atgcgagttg taaaatacca   7800

gctctacaag aagctaggct ctgtgacggc atagttttca gtagctttat cacaatattc   7860

acaatggaga attatatgac atggtagcag aaataggccc ttttatgtgt tgcttctatt   7920

ttacctcaaa ttgtagatat agggtaatca ataaaatcca tccatgcctt tcacacacta   7980

agt                                                                 7983


<210>  5073
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  5073

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala 
            580


<210>  5074
<211>  4118
<212>  DNA
<213>  Homo sapiens

<400>  5074
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   1980

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   2040

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2100

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2160

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2220

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2280

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2340

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2400

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2460

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2520

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2580

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2640

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2700

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2760

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2820

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2880

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   2940

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   3000

cggtcattag accatttcca ggacttgtga ttaataacca gctggttgat cagagtgagt   3060

cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt ccagccacag   3120

aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac cccacgtggt   3180

agacctcttc cctcctaggc ttaaagtatc agtggttgag aagagctttt cggacctgtt   3240

actaccccaa gctgtagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct   3300

cctacttctc ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt   3360

cagttcttta gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg   3420

ctctccttaa tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa   3480

gctatctctc atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca   3540

cctaacagtc agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc   3600

tcttccactt ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg   3660

gttgaggatt ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg   3720

cgcggattct taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc   3780

attatttcct agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca   3840

gggggctaag gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt   3900

gagatttcac aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg   3960

acggcatagt tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt   4020

agcagaaata ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt   4080

aatcaataaa atccatccat gcctttcaca cactaagt                           4118


<210>  5075
<211>  974
<212>  PRT
<213>  Homo sapiens

<400>  5075

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala 
545                 550                 555                 560


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
                565                 570                 575


Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile 
            580                 585                 590


Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile 
        595                 600                 605


Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu 
    610                 615                 620


Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys 
625                 630                 635                 640


Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys 
                645                 650                 655


Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro 
            660                 665                 670


Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val 
        675                 680                 685


Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala 
    690                 695                 700


Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys 
705                 710                 715                 720


Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala 
                725                 730                 735


Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu 
            740                 745                 750


Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu 
        755                 760                 765


Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro 
    770                 775                 780


Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro 
785                 790                 795                 800


Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly 
                805                 810                 815


Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn 
            820                 825                 830


Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val 
        835                 840                 845


Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe 
    850                 855                 860


Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val 
865                 870                 875                 880


Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr 
                885                 890                 895


Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile 
            900                 905                 910


Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln 
        915                 920                 925


Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala 
    930                 935                 940


Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr 
945                 950                 955                 960


Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
                965                 970


<210>  5076
<211>  5171
<212>  DNA
<213>  Homo sapiens

<400>  5076
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   2040

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2100

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2160

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2220

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2280

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2340

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2400

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2460

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2520

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2580

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2640

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2700

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2760

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2820

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2880

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   2940

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   3000

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3060

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3120

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3180

ttcacggtca ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt   3240

gagtcagaag gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc   3300

acagaaggta aaaggacctc ttccctccta gggtaaatca gcttctgtgt cagggatgct   3360

gtgtggtgtc catctgaacc ccctgcatac gcgtagctaa tgtgatctcc ccactttcac   3420

ataagatggt ggccctgcct tcagggaatg tgggagccag gtgggagcct tcccggatat   3480

ttaagctaga agattctaca gggagattct ccttggatca atatatgtct ctcagtcaaa   3540

gatgtaaaag cacttttgcc ttaaaaagaa tgttctgttt ctaaatagag tcaacgttgt   3600

cctcctcatt ggaattcact atgagtcaga atcattagac tgactttttt ttttccatag   3660

taatagtatt ttgcagagtc tcacagagct gcagatcttt tgttcatctt gcagagttaa   3720

caagtctgat cctgttagtc cagatttctt aaatttggcc aagttataat aggagcagta   3780

gcttgagacc cgaagtcagg aaactttgac aatggatttt tttttttaat ccagagactt   3840

gtactggaat ttgccttacc ctgtcagctc atggacttaa ggtttcatcc cgctttatga   3900

gtgcttctga atccaagtca ttgttacctg aatttgcaaa ttaagttgtg atattcgtga   3960

ctgttaaatt cctgtaatta gattaacctc tttgcttgct tgtttgtttt ctctcctatt   4020

ttagcttaaa gtatcagtgg ttgagaagag cttttcggac ctgttactac cccaagctgt   4080

gtaatatact tgtataacag aaataccttc tatacaaacc tttttttcta cttttagata   4140

gaaatgtcta ctttttcagc agttctgtga attaaagagc agagtgactg tgggtctgga   4200

atggctggtg tacttgggaa tgtactatca ggattttaca gcaatgctgg gaaatgacag   4260

ggaaaatgac aggaatgaat ctcaccagat tttttatgta ctcagcagag ccttgagtta   4320

cggtgtttat tttccaatca agtgaagata tctcctactt ctcctactgg aacatctcag   4380

cttctgcagt gaagaaaaat tcctgtgata gttcagttct ttagtttttc tatttgaaaa   4440

aaaaaaatca tttaaatgat cctttgttca cggctctcct taatgactga gtgaacagtt   4500

cctatctgta tatttgacta aaccttttcc taagctatct ctcatggttc ctatgttttt   4560

ttatcataat taaaagcaaa accatctgga tcacctaaca gtcagaggtc agtatctcag   4620

cgtgtgaatt atagaggaaa tacagagaga acctcttcca cttttacttt tcgtccaaat   4680

aaaatgcatg gtgtaccaga agttgaagat cgggttgagg attggggcta gctcgatgac   4740

actaaggccc caacatcgcg ggacctgctg tggcgcggat tcttaggaac gctgttctag   4800

ccggccccct ctccaggggt cgccgtggcc ggcattattt cctagttctt cttgtaaccc   4860

tgaggtgcca gcgcggggag tgaggagggg tcagggggct aaggatgcaa cctctgacgt   4920

tctgcgcctt cctaggagag tcttacatgt gttgagattt cacaagcaat gcgagttgta   4980

aaataccagc tctacaagaa gctaggctct gtgacggcat agttttcagt agctttatca   5040

caatattcac aatggagaat tatatgacat ggtagcagaa ataggccctt ttatgtgttg   5100

cttctatttt acctcaaatt gtagatatag ggtaatcaat aaaatccatc catgcctttc   5160

acacactaag t                                                        5171


<210>  5077
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  5077

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala 
            580


<210>  5078
<211>  3676
<212>  DNA
<213>  Homo sapiens

<400>  5078
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1080

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1140

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1200

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1260

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1320

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1380

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1440

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1500

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1560

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1620

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1680

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1740

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1800

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1860

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1920

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   1980

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2040

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2100

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2160

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2220

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2280

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2340

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2400

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2460

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2520

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2580

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2640

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2700

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2760

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2820

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   2880

cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg atcagagtga   2940

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   3000

agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag accccacgtg   3060

gtagacctct tccctcctag gcaaaaccat ctggatcacc taacagtcag aggtcagtat   3120

ctcagcgtgt gaattataga ggaaatacag agagaacctc ttccactttt acttttcgtc   3180

caaataaaat gcatggtgta ccagaagttg aagatcgggt tgaggattgg ggctagctcg   3240

atgacactaa ggccccaaca tcgcgggacc tgctgtggcg cggattctta ggaacgctgt   3300

tctagccggc cccctctcca ggggtcgccg tggccggcat tatttcctag ttcttcttgt   3360

aaccctgagg tgccagcgcg gggagtgagg aggggtcagg gggctaagga tgcaacctct   3420

gacgttctgc gccttcctag gagagtctta catgtgttga gatttcacaa gcaatgcgag   3480

ttgtaaaata ccagctctac aagaagctag gctctgtgac ggcatagttt tcagtagctt   3540

tatcacaata ttcacaatgg agaattatat gacatggtag cagaaatagg cccttttatg   3600

tgttgcttct attttacctc aaattgtaga tatagggtaa tcaataaaat ccatccatgc   3660

ctttcacaca ctaagt                                                   3676


<210>  5079
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  5079

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
                565                 570                 575


Ser Ser Leu Leu Lys Asn Leu Asn 
            580


<210>  5080
<211>  5048
<212>  DNA
<213>  Homo sapiens

<400>  5080
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1080

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1140

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1200

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1260

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1320

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1380

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1440

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1500

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1560

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1620

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1680

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1740

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1800

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1860

aagagatttt taatttgaaa tttgcttaga tttgttgaca gcggtttcct ggagtgctgt   1920

cttgagaacg attctgagga ggctcagcaa gaaagagtgt ttcagttgat tgggtgtgtc   1980

tgtcatggag aaggaactca agctcttgga ctcaccgagg cagtaaaagt accatatcct   2040

gtgtttgaat caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc   2100

cgaagcccta cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa   2160

atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct   2220

agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat   2280

tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc   2340

tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg   2400

agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa   2460

aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg   2520

ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg   2580

ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa   2640

gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc   2700

acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca   2760

tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga   2820

ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg   2880

aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca   2940

attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt caaagccccc   3000

agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc   3060

acggtcatta gaccatttcc aggacttgtg attaataacc agctggttga tcagagtgag   3120

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   3180

gaaggtaaaa ggacctcttc cctcctaggg taaatcagct tctgtgtcag ggatgctgtg   3240

tggtgtccat ctgaaccccc tgcatacgcg tagctaatgt gatctcccca ctttcacata   3300

agatggtggc cctgccttca gggaatgtgg gagccaggtg ggagccttcc cggatattta   3360

agctagaaga ttctacaggg agattctcct tggatcaata tatgtctctc agtcaaagat   3420

gtaaaagcac ttttgcctta aaaagaatgt tctgtttcta aatagagtca acgttgtcct   3480

cctcattgga attcactatg agtcagaatc attagactga cttttttttt tccatagtaa   3540

tagtattttg cagagtctca cagagctgca gatcttttgt tcatcttgca gagttaacaa   3600

gtctgatcct gttagtccag atttcttaaa tttggccaag ttataatagg agcagtagct   3660

tgagacccga agtcaggaaa ctttgacaat ggattttttt ttttaatcca gagacttgta   3720

ctggaatttg ccttaccctg tcagctcatg gacttaaggt ttcatcccgc tttatgagtg   3780

cttctgaatc caagtcattg ttacctgaat ttgcaaatta agttgtgata ttcgtgactg   3840

ttaaattcct gtaattagat taacctcttt gcttgcttgt ttgttttctc tcctatttta   3900

gcttaaagta tcagtggttg agaagagctt ttcggacctg ttactacccc aagctgtgta   3960

atatacttgt ataacagaaa taccttctat acaaaccttt ttttctactt ttagatagaa   4020

atgtctactt tttcagcagt tctgtgaatt aaagagcaga gtgactgtgg gtctggaatg   4080

gctggtgtac ttgggaatgt actatcagga ttttacagca atgctgggaa atgacaggga   4140

aaatgacagg aatgaatctc accagatttt ttatgtactc agcagagcct tgagttacgg   4200

tgtttatttt ccaatcaagt gaagatatct cctacttctc ctactggaac atctcagctt   4260

ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa   4320

aaaatcattt aaatgatcct ttgttcacgg ctctccttaa tgactgagtg aacagttcct   4380

atctgtatat ttgactaaac cttttcctaa gctatctctc atggttccta tgttttttta   4440

tcataattaa aagcaaaacc atctggatca cctaacagtc agaggtcagt atctcagcgt   4500

gtgaattata gaggaaatac agagagaacc tcttccactt ttacttttcg tccaaataaa   4560

atgcatggtg taccagaagt tgaagatcgg gttgaggatt ggggctagct cgatgacact   4620

aaggccccaa catcgcggga cctgctgtgg cgcggattct taggaacgct gttctagccg   4680

gccccctctc caggggtcgc cgtggccggc attatttcct agttcttctt gtaaccctga   4740

ggtgccagcg cggggagtga ggaggggtca gggggctaag gatgcaacct ctgacgttct   4800

gcgccttcct aggagagtct tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa   4860

taccagctct acaagaagct aggctctgtg acggcatagt tttcagtagc tttatcacaa   4920

tattcacaat ggagaattat atgacatggt agcagaaata ggccctttta tgtgttgctt   4980

ctattttacc tcaaattgta gatatagggt aatcaataaa atccatccat gcctttcaca   5040

cactaagt                                                            5048


<210>  5081
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  5081

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  5082
<211>  7107
<212>  DNA
<213>  Homo sapiens

<400>  5082
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   1980

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   2040

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2100

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2160

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2220

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2280

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2340

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2400

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2460

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2520

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2580

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2640

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2700

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2760

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2820

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2880

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   2940

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   3000

cggtcattag gtaagtgaga gtttcctgct tagtcacagg agcgaatctg gagctcatga   3060

ggctgactct tctaaaatgc agccacaggt agtcatcgaa tccggcttcc tatgctgtgc   3120

aatcaacaaa tcaaaataac ttgtgtcatc attagaatgt cagatgtgct tctacgaact   3180

aagctgactc ttttaattct ttggcaaagg gttggcaaac taggactgtt tgccaaattc   3240

aggctgcctc ctatttttag agtcttcctg aaacacagct acacccgtat tatccatggc   3300

tgctttcctg tcacagtgag taagtagctg ggactgagaa ggcatggcct ccaaagtcta   3360

aaatatttac tctctagcac tttgtagaaa aaccttagct aggcacagtg gctaacgcct   3420

gtaatcccag cattttggga ggccaaggca ggcagatcac ctgaggtcag gagttccaga   3480

ccagcctggc caacatggtg aaatcccatc tctacaaaaa taaaacagtt agctgggcat   3540

gatggcgggt gcctgtaatc ccagctactc gggaggctga ggcaggatag tcgcttgaac   3600

ccaggaggtg gaggttgcaa tgagccaaga tcatgccact gcactccagc ctggacgaca   3660

gagtgagact ccatcacaag aaaaaaagaa ctttgtcaac ctctgtctta gggcgccttg   3720

tcacaggctt cgggtcagac ggattcaacc ttgcatcagc catttgttag ccaggtcact   3780

ctgttctttg tctgtaaatg agattgatcg ttgttcccac tgagagtgtc agctccttcc   3840

cgtagagcag gcatgatgat tgtactcacc tctgacacca ttgtgagtgc cacattcctt   3900

cccacgtcct tgtcactgta agagatgccc acctgagcac caaccccagg ttatcttccc   3960

ctttgtcttc cagcccccca gaaacagcta cgactcaacc tacccaatca tttcatcatc   4020

agattgccac tgtctctagt tcaggtctct tgggactggc actcagaaat ctcataataa   4080

atcctcttga ggcttctcat acactcgtct tcttccaatc ttctttccct caaaatctca   4140

tattttggtt ccacttcacc caccgtcatt ctccatatca ctcccaggag ttaggcaaaa   4200

agccccttcc gttcttccgt atgttaaact tagaatcact ctgttccctg ctctgcgttt   4260

ctattttttg tttttcctcc atttactagt agcttaacac tttctaacag tgttcttatt   4320

attgatacgt atctatctct tccataagct tataaggtca cggataatac ttctcattgt   4380

agtacgtaaa tgacgtgggc tagatatgag ttgaataaac agttatacct gtaaattctt   4440

acagagtgaa aataaattgt tatactttac aatttgtttc tctctttaga ccatttccag   4500

gacttgtgat taataaccgt gagtattttg tgaagtgttt tgtttttgtt ttttcctggg   4560

gtctgacgtg tgtgcgtgtg agtgtgtata catgcttaac gtatatcacg ttacttcacc   4620

tatgtcagta accaggccaa atacttgttt tagccctcag taaaaacacc aggcacttcc   4680

tagttgtaaa attattcaag cttcttaact tcctatcctc gatgcactta atcataaaat   4740

ggtaataata gcaccgattt tgggggagtc gttccagtag atggaaagca tctggaacag   4800

gtgtcagcaa gctcctgccg acgtgtatgc ataaagtttt attgaaacca ccatcgtgtc   4860

catttgttta tggcagaact gagagatggc agcagcaagt gtgtgcctgc aaaacctaaa   4920

atatttacta attggctctg caagaaaaga gtttgcatcc ccctaaccta gaacagtgtc   4980

tagcctctag tatgtgttta gcctacagta tgtgctcagc gaatacaatc tatatttatt   5040

actgctttta tgactgttat aattactgtg cttggatttc gttacaaagt aagtcacaat   5100

gtgcctgctt ctgttagtat ttcagcacag tgcctggcac acatggggct ctcaaatatt   5160

gctgagcgag tgaacaaatg tcctttcaat tccttaacgt tgatgtcatt ttcaatagta   5220

ttttgagcca aacttaattt tgcgagtgtg ttttgttttc ttaactttat tattaaaaat   5280

gtataaaagt gaggccaggc gtggtggctc acgcctgtaa tcccagcagt ttgggaggct   5340

gaggcaggcg gatcagttga ggttgggagt tggagaccag cccgtccaac atggtgaaag   5400

cctgtctcta ctaaaaatac aaaaatcagc tgggtgtggt ggcgcgtgcc tgtaatccca   5460

gctactcagg aggctgaggc aggagagttg cttgaatcct agaggtggag gttgcagtga   5520

gctgagatcg tgccattgca ctccagcctg ggcaacaaga gcaaaactct gtcccaataa   5580

ataaataaat aaaatgttct cttttgttcc tgttcttgtg cggtagtgtg gtatagagtt   5640

ttatggtaat tactgtgaat tagtgattct gagggacata tcagaactct gaggtttgtt   5700

tccttctcat cttgagggaa acagcaaatg tatgttaaaa tgcttttcca agggaacaac   5760

acatccttac attatttaaa ccaatctgct tcattttcag agctggttga tcagagtgag   5820

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   5880

gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga ccccacgtgg   5940

tagacctctt ccctcctagg cttaaagtat cagtggttga gaagagcttt tcggacctgt   6000

tactacccca agctgtgtaa tatacttgta taacagaaat accttctata caaacctttt   6060

tttctacttt tagatagaaa tgtctacttt ttcagcagtt ctgtgaatta aagagcagag   6120

tgactgtggg tctggaatgg ctggtgtact tgggaatgta ctatcaggat tttacagcaa   6180

tgctgggaaa tgacagggaa aatgacagga atgaatctca ccagattttt tatgtactca   6240

gcagagcctt gagttacggt gtttattttc caatcaagtg aagatatctc ctacttctcc   6300

tactggaaca tctcagcttc tgcagtgaag aaaaattcct gtgatagttc agttctttag   6360

tttttctatt tgaaaaaaaa aaatcattta aatgatcctt tgttcacggc tctccttaat   6420

gactgagtga acagttccta tctgtatatt tgactaaacc ttttcctaag ctatctctca   6480

tggttcctat gtttttttat cataattaaa agcaaaacca tctggatcac ctaacagtca   6540

gaggtcagta tctcagcgtg tgaattatag aggaaataca gagagaacct cttccacttt   6600

tacttttcgt ccaaataaaa tgcatggtgt accagaagtt gaagatcggg ttgaggattg   6660

gggctagctc gatgacacta aggccccaac atcgcgggac ctgctgtggc gcggattctt   6720

aggaacgctg ttctagccgg ccccctctcc aggggtcgcc gtggccggca ttatttccta   6780

gttcttcttg taaccctgag gtgccagcgc ggggagtgag gaggggtcag ggggctaagg   6840

atgcaacctc tgacgttctg cgccttccta ggagagtctt acatgtgttg agatttcaca   6900

agcaatgcga gttgtaaaat accagctcta caagaagcta ggctctgtga cggcatagtt   6960

ttcagtagct ttatcacaat attcacaatg gagaattata tgacatggta gcagaaatag   7020

gcccttttat gtgttgcttc tattttacct caaattgtag atatagggta atcaataaaa   7080

tccatccatg cctttcacac actaagt                                       7107


<210>  5083
<211>  918
<212>  PRT
<213>  Homo sapiens

<400>  5083

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala 
545                 550                 555                 560


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
                565                 570                 575


Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile 
            580                 585                 590


Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile 
        595                 600                 605


Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu 
    610                 615                 620


Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys 
625                 630                 635                 640


Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys 
                645                 650                 655


Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro 
            660                 665                 670


Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val 
        675                 680                 685


Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala 
    690                 695                 700


Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys 
705                 710                 715                 720


Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala 
                725                 730                 735


Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu 
            740                 745                 750


Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu 
        755                 760                 765


Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro 
    770                 775                 780


Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro 
785                 790                 795                 800


Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly 
                805                 810                 815


Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn 
            820                 825                 830


Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val 
        835                 840                 845


Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe 
    850                 855                 860


Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val 
865                 870                 875                 880


Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr 
                885                 890                 895


Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile 
            900                 905                 910


Lys Phe Thr Val Ile Arg 
        915


<210>  5084
<211>  3924
<212>  DNA
<213>  Homo sapiens

<400>  5084
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag    960

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1020

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1080

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1140

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1200

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1260

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1320

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1380

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1440

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1500

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1560

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1620

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1680

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1740

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagctc   1800

aagctcttgg actcaccgag gcagtaaaag taccatatcc tgtgtttgaa tcaaacccgg   1860

agttcttgta tgtggaaggc ttgccagagg ggattccctt ccgaagccct acctggtttg   1920

gaattccacg acttgaaagg atcgtccgcg ggagtaataa aatcaagttc gttgttaaaa   1980

aacctgaact agttatttcc tacttgcctc ctgggatggc tagtaaaata aacactaaag   2040

ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa ttcaaaggtt cctgaaattg   2100

aggtcaccgt ggaaggccct aataacaaca atcctcaaac ctcagctgtt cgaaccccga   2160

cccagactaa cggttctaac gttcccttca agccacgagg gagagagttt tcctttgagg   2220

cctggaatgc caaaatcacg gacctaaaac agaaagttga aaatctcttc aatgagaaat   2280

gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc gttcgcgtta tttgagtctt   2340

tcccggaaga cttttatgtg gaaggcttac ctgagggtgt gccattccga agaccatcga   2400

cttttggcat tccgaggctg gagaagatac tcagaaacaa agccaaaatt aagttcatca   2460

ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag cacctcctct aagagccctc   2520

ccagaaaaat aaattcatca cccaatgtta atactactgc atcaggtgtt gaagacctta   2580

acatcattca ggtgacaatt ccagatgatg ataatgaaag actctcgaaa gttgaaaaag   2640

ctagacagct aagagaacaa gtgaatgacc tctttagtcg gaaatttggt gaagctattg   2700

gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac aattaaccct ggctgtgtgg   2760

tggttgatgg catgcccccg ggggtgtcct tcaaagcccc cagctacctg gaaatcagct   2820

ccatgagaag gatcttagac tctgccgagt ttatcaaatt cacggtcatt agaccatttc   2880

caggacttgt gattaataac cagctggttg atcagagtga gtcagaaggc cccgtgatac   2940

aagaatcagc tgaaccaagc cagttggaag ttccagccac agaagaaata aaagagactg   3000

atggaagctc tcagatcaag caagaaccag accccacgtg gtagacctct tccctcctag   3060

gagccttgag ttacggtgtt tattttccaa tcaagtgaag atatctccta cttctcctac   3120

tggaacatct cagcttctgc agtgaagaaa aattcctgtg atagttcagt tctttagttt   3180

ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt tcacggctct ccttaatgac   3240

tgagtgaaca gttcctatct gtatatttga ctaaaccttt tcctaagcta tctctcatgg   3300

ttcctatgtt tttttatcat aattaaaagc aaaaccatct ggatcaccta acagtcagag   3360

gtcagtatct cagcgtgtga attatagagg aaatacagag agaacctctt ccacttttac   3420

ttttcgtcca aataaaatgc atggtgtacc agaagttgaa gatcgggttg aggattgggg   3480

ctagctcgat gacactaagg ccccaacatc gcgggacctg ctgtggcgcg gattcttagg   3540

aacgctgttc tagccggccc cctctccagg ggtcgccgtg gccggcatta tttcctagtt   3600

cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg gctaaggatg   3660

caacctctga cgttctgcgc cttcctagga gagtcttaca tgtgttgaga tttcacaagc   3720

aatgcgagtt gtaaaatacc agctctacaa gaagctaggc tctgtgacgg catagttttc   3780

agtagcttta tcacaatatt cacaatggag aattatatga catggtagca gaaataggcc   3840

cttttatgtg ttgcttctat tttacctcaa attgtagata tagggtaatc aataaaatcc   3900

atccatgcct ttcacacact aagt                                          3924


<210>  5085
<211>  928
<212>  PRT
<213>  Homo sapiens

<400>  5085

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro 
        515                 520                 525


Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu 
    530                 535                 540


Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu 
545                 550                 555                 560


Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro 
                565                 570                 575


Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn 
            580                 585                 590


Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn 
        595                 600                 605


Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn 
    610                 615                 620


Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser 
625                 630                 635                 640


Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp 
                645                 650                 655


Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn 
            660                 665                 670


Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro 
        675                 680                 685


Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu 
    690                 695                 700


Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg 
705                 710                 715                 720


Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys 
                725                 730                 735


Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys 
            740                 745                 750


Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala 
        755                 760                 765


Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp 
    770                 775                 780


Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu 
785                 790                 795                 800


Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met 
                805                 810                 815


Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly 
            820                 825                 830


Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro 
        835                 840                 845


Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu 
    850                 855                 860


Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn 
865                 870                 875                 880


Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu 
                885                 890                 895


Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys 
            900                 905                 910


Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
        915                 920                 925


<210>  5086
<211>  3978
<212>  DNA
<213>  Homo sapiens

<400>  5086
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   2040

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2100

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2160

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2220

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2280

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2340

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2400

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2460

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2520

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2580

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2640

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2700

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2760

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2820

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2880

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   2940

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   3000

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3060

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3120

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3180

ttcacggtca ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt   3240

gagtcagaag gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc   3300

acagaagaaa taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg   3360

tggtagacct cttccctcct aggcaaaacc atctggatca cctaacagtc agaggtcagt   3420

atctcagcgt gtgaattata gaggaaatac agagagaacc tcttccactt ttacttttcg   3480

tccaaataaa atgcatggtg taccagaagt tgaagatcgg gttgaggatt ggggctagct   3540

cgatgacact aaggccccaa catcgcggga cctgctgtgg cgcggattct taggaacgct   3600

gttctagccg gccccctctc caggggtcgc cgtggccggc attatttcct agttcttctt   3660

gtaaccctga ggtgccagcg cggggagtga ggaggggtca gggggctaag gatgcaacct   3720

ctgacgttct gcgccttcct aggagagtct tacatgtgtt gagatttcac aagcaatgcg   3780

agttgtaaaa taccagctct acaagaagct aggctctgtg acggcatagt tttcagtagc   3840

tttatcacaa tattcacaat ggagaattat atgacatggt agcagaaata ggccctttta   3900

tgtgttgctt ctattttacc tcaaattgta gatatagggt aatcaataaa atccatccat   3960

gcctttcaca cactaagt                                                 3978


<210>  5087
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  5087

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala 
            580


<210>  5088
<211>  4246
<212>  DNA
<213>  Homo sapiens

<400>  5088
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   2040

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2100

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2160

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2220

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2280

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2340

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2400

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2460

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2520

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2580

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2640

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2700

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2760

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2820

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2880

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   2940

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   3000

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3060

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3120

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3180

ttcacggtca ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt   3240

gagtcagaag gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc   3300

acagaagaaa taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg   3360

tggtagacct cttccctcct aggagccttg agttacggtg tttattttcc aatcaagtga   3420

agatatctcc tacttctcct actggaacat ctcagcttct gcagtgaaga aaaattcctg   3480

tgatagttca gttctttagt ttttctattt gaaaaaaaaa aatcatttaa atgatccttt   3540

gttcacggct ctccttaatg actgagtgaa cagttcctat ctgtatattt gactaaacct   3600

tttcctaagc tatctctcat ggttcctatg tttttttatc ataattaaaa gcaaaaccat   3660

ctggatcacc taacagtcag aggtcagtat ctcagcgtgt gaattataga ggaaatacag   3720

agagaacctc ttccactttt acttttcgtc caaataaaat gcatggtgta ccagaagttg   3780

aagatcgggt tgaggattgg ggctagctcg atgacactaa ggccccaaca tcgcgggacc   3840

tgctgtggcg cggattctta ggaacgctgt tctagccggc cccctctcca ggggtcgccg   3900

tggccggcat tatttcctag ttcttcttgt aaccctgagg tgccagcgcg gggagtgagg   3960

aggggtcagg gggctaagga tgcaacctct gacgttctgc gccttcctag gagagtctta   4020

catgtgttga gatttcacaa gcaatgcgag ttgtaaaata ccagctctac aagaagctag   4080

gctctgtgac ggcatagttt tcagtagctt tatcacaata ttcacaatgg agaattatat   4140

gacatggtag cagaaatagg cccttttatg tgttgcttct attttacctc aaattgtaga   4200

tatagggtaa tcaataaaat ccatccatgc ctttcacaca ctaagt                  4246


<210>  5089
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  5089

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala 
            580


<210>  5090
<211>  3731
<212>  DNA
<213>  Homo sapiens

<400>  5090
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agctcaagct cttggactca ccgaggcagt aaaagtacca tatcctgtgt   1920

ttgaatcaaa cccggagttc ttgtatgtgg aaggcttgcc agaggggatt cccttccgaa   1980

gccctacctg gtttggaatt ccacgacttg aaaggatcgt ccgcgggagt aataaaatca   2040

agttcgttgt taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta   2100

aaataaacac taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa   2160

aggttcctga aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag   2220

ctgttcgaac cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag   2280

agttttcctt tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc   2340

tcttcaatga gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg   2400

cgttatttga gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat   2460

tccgaagacc atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca   2520

aaattaagtt catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct   2580

cctctaagag ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag   2640

gtgttgaaga ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct   2700

cgaaagttga aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat   2760

ttggtgaagc tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta   2820

accctggctg tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct   2880

acctggaaat cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg   2940

tcattagacc atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag   3000

aaggccccgt gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag   3060

aaataaaaga gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga   3120

cctcttccct cctaggcaaa accatctgga tcacctaaca gtcagaggtc agtatctcag   3180

cgtgtgaatt atagaggaaa tacagagaga acctcttcca cttttacttt tcgtccaaat   3240

aaaatgcatg gtgtaccaga agttgaagat cgggttgagg attggggcta gctcgatgac   3300

actaaggccc caacatcgcg ggacctgctg tggcgcggat tcttaggaac gctgttctag   3360

ccggccccct ctccaggggt cgccgtggcc ggcattattt cctagttctt cttgtaaccc   3420

tgaggtgcca gcgcggggag tgaggagggg tcagggggct aaggatgcaa cctctgacgt   3480

tctgcgcctt cctaggagag tcttacatgt gttgagattt cacaagcaat gcgagttgta   3540

aaataccagc tctacaagaa gctaggctct gtgacggcat agttttcagt agctttatca   3600

caatattcac aatggagaat tatatgacat ggtagcagaa ataggccctt ttatgtgttg   3660

cttctatttt acctcaaatt gtagatatag ggtaatcaat aaaatccatc catgcctttc   3720

acacactaag t                                                        3731


<210>  5091
<211>  953
<212>  PRT
<213>  Homo sapiens

<400>  5091

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu 
    530                 535                 540


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
545                 550                 555                 560


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
                565                 570                 575


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
            580                 585                 590


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
        595                 600                 605


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
    610                 615                 620


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
625                 630                 635                 640


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
                645                 650                 655


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
            660                 665                 670


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
        675                 680                 685


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
    690                 695                 700


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
705                 710                 715                 720


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
                725                 730                 735


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
            740                 745                 750


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
        755                 760                 765


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
    770                 775                 780


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
785                 790                 795                 800


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
                805                 810                 815


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
            820                 825                 830


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
        835                 840                 845


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
    850                 855                 860


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
865                 870                 875                 880


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
                885                 890                 895


Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser 
            900                 905                 910


Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu 
        915                 920                 925


Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln 
    930                 935                 940


Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  5092
<211>  7044
<212>  DNA
<213>  Homo sapiens

<400>  5092
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agctcaagct cttggactca ccgaggcagt aaaagtacca tatcctgtgt   1920

ttgaatcaaa cccggagttc ttgtatgtgg aaggcttgcc agaggggatt cccttccgaa   1980

gccctacctg gtttggaatt ccacgacttg aaaggatcgt ccgcgggagt aataaaatca   2040

agttcgttgt taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta   2100

aaataaacac taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa   2160

aggttcctga aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag   2220

ctgttcgaac cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag   2280

agttttcctt tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc   2340

tcttcaatga gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg   2400

cgttatttga gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat   2460

tccgaagacc atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca   2520

aaattaagtt catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct   2580

cctctaagag ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag   2640

gtgttgaaga ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct   2700

cgaaagttga aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat   2760

ttggtgaagc tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta   2820

accctggctg tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct   2880

acctggaaat cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg   2940

tcattaggta agtgagagtt tcctgcttag tcacaggagc gaatctggag ctcatgaggc   3000

tgactcttct aaaatgcagc cacaggtagt catcgaatcc ggcttcctat gctgtgcaat   3060

caacaaatca aaataacttg tgtcatcatt agaatgtcag atgtgcttct acgaactaag   3120

ctgactcttt taattctttg gcaaagggtt ggcaaactag gactgtttgc caaattcagg   3180

ctgcctccta tttttagagt cttcctgaaa cacagctaca cccgtattat ccatggctgc   3240

tttcctgtca cagtgagtaa gtagctggga ctgagaaggc atggcctcca aagtctaaaa   3300

tatttactct ctagcacttt gtagaaaaac cttagctagg cacagtggct aacgcctgta   3360

atcccagcat tttgggaggc caaggcaggc agatcacctg aggtcaggag ttccagacca   3420

gcctggccaa catggtgaaa tcccatctct acaaaaataa aacagttagc tgggcatgat   3480

ggcgggtgcc tgtaatccca gctactcggg aggctgaggc aggatagtcg cttgaaccca   3540

ggaggtggag gttgcaatga gccaagatca tgccactgca ctccagcctg gacgacagag   3600

tgagactcca tcacaagaaa aaaagaactt tgtcaacctc tgtcttaggg cgccttgtca   3660

caggcttcgg gtcagacgga ttcaaccttg catcagccat ttgttagcca ggtcactctg   3720

ttctttgtct gtaaatgaga ttgatcgttg ttcccactga gagtgtcagc tccttcccgt   3780

agagcaggca tgatgattgt actcacctct gacaccattg tgagtgccac attccttccc   3840

acgtccttgt cactgtaaga gatgcccacc tgagcaccaa ccccaggtta tcttcccctt   3900

tgtcttccag ccccccagaa acagctacga ctcaacctac ccaatcattt catcatcaga   3960

ttgccactgt ctctagttca ggtctcttgg gactggcact cagaaatctc ataataaatc   4020

ctcttgaggc ttctcataca ctcgtcttct tccaatcttc tttccctcaa aatctcatat   4080

tttggttcca cttcacccac cgtcattctc catatcactc ccaggagtta ggcaaaaagc   4140

cccttccgtt cttccgtatg ttaaacttag aatcactctg ttccctgctc tgcgtttcta   4200

ttttttgttt ttcctccatt tactagtagc ttaacacttt ctaacagtgt tcttattatt   4260

gatacgtatc tatctcttcc ataagcttat aaggtcacgg ataatacttc tcattgtagt   4320

acgtaaatga cgtgggctag atatgagttg aataaacagt tatacctgta aattcttaca   4380

gagtgaaaat aaattgttat actttacaat ttgtttctct ctttagacca tttccaggac   4440

ttgtgattaa taaccgtgag tattttgtga agtgttttgt ttttgttttt tcctggggtc   4500

tgacgtgtgt gcgtgtgagt gtgtatacat gcttaacgta tatcacgtta cttcacctat   4560

gtcagtaacc aggccaaata cttgttttag ccctcagtaa aaacaccagg cacttcctag   4620

ttgtaaaatt attcaagctt cttaacttcc tatcctcgat gcacttaatc ataaaatggt   4680

aataatagca ccgattttgg gggagtcgtt ccagtagatg gaaagcatct ggaacaggtg   4740

tcagcaagct cctgccgacg tgtatgcata aagttttatt gaaaccacca tcgtgtccat   4800

ttgtttatgg cagaactgag agatggcagc agcaagtgtg tgcctgcaaa acctaaaata   4860

tttactaatt ggctctgcaa gaaaagagtt tgcatccccc taacctagaa cagtgtctag   4920

cctctagtat gtgtttagcc tacagtatgt gctcagcgaa tacaatctat atttattact   4980

gcttttatga ctgttataat tactgtgctt ggatttcgtt acaaagtaag tcacaatgtg   5040

cctgcttctg ttagtatttc agcacagtgc ctggcacaca tggggctctc aaatattgct   5100

gagcgagtga acaaatgtcc tttcaattcc ttaacgttga tgtcattttc aatagtattt   5160

tgagccaaac ttaattttgc gagtgtgttt tgttttctta actttattat taaaaatgta   5220

taaaagtgag gccaggcgtg gtggctcacg cctgtaatcc cagcagtttg ggaggctgag   5280

gcaggcggat cagttgaggt tgggagttgg agaccagccc gtccaacatg gtgaaagcct   5340

gtctctacta aaaatacaaa aatcagctgg gtgtggtggc gcgtgcctgt aatcccagct   5400

actcaggagg ctgaggcagg agagttgctt gaatcctaga ggtggaggtt gcagtgagct   5460

gagatcgtgc cattgcactc cagcctgggc aacaagagca aaactctgtc ccaataaata   5520

aataaataaa atgttctctt ttgttcctgt tcttgtgcgg tagtgtggta tagagtttta   5580

tggtaattac tgtgaattag tgattctgag ggacatatca gaactctgag gtttgtttcc   5640

ttctcatctt gagggaaaca gcaaatgtat gttaaaatgc ttttccaagg gaacaacaca   5700

tccttacatt atttaaacca atctgcttca ttttcagagc tggttgatca gagtgagtca   5760

gaaggccccg tgatacaaga atcagctgaa ccaagccagt tggaagttcc agccacagaa   5820

gaaataaaag agactgatgg aagctctcag atcaagcaag aaccagaccc cacgtggtag   5880

acctcttccc tcctaggctt aaagtatcag tggttgagaa gagcttttcg gacctgttac   5940

taccccaagc tgtgtaatat acttgtataa cagaaatacc ttctatacaa accttttttt   6000

ctacttttag atagaaatgt ctactttttc agcagttctg tgaattaaag agcagagtga   6060

ctgtgggtct ggaatggctg gtgtacttgg gaatgtacta tcaggatttt acagcaatgc   6120

tgggaaatga cagggaaaat gacaggaatg aatctcacca gattttttat gtactcagca   6180

gagccttgag ttacggtgtt tattttccaa tcaagtgaag atatctccta cttctcctac   6240

tggaacatct cagcttctgc agtgaagaaa aattcctgtg atagttcagt tctttagttt   6300

ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt tcacggctct ccttaatgac   6360

tgagtgaaca gttcctatct gtatatttga ctaaaccttt tcctaagcta tctctcatgg   6420

ttcctatgtt tttttatcat aattaaaagc aaaaccatct ggatcaccta acagtcagag   6480

gtcagtatct cagcgtgtga attatagagg aaatacagag agaacctctt ccacttttac   6540

ttttcgtcca aataaaatgc atggtgtacc agaagttgaa gatcgggttg aggattgggg   6600

ctagctcgat gacactaagg ccccaacatc gcgggacctg ctgtggcgcg gattcttagg   6660

aacgctgttc tagccggccc cctctccagg ggtcgccgtg gccggcatta tttcctagtt   6720

cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg gctaaggatg   6780

caacctctga cgttctgcgc cttcctagga gagtcttaca tgtgttgaga tttcacaagc   6840

aatgcgagtt gtaaaatacc agctctacaa gaagctaggc tctgtgacgg catagttttc   6900

agtagcttta tcacaatatt cacaatggag aattatatga catggtagca gaaataggcc   6960

cttttatgtg ttgcttctat tttacctcaa attgtagata tagggtaatc aataaaatcc   7020

atccatgcct ttcacacact aagt                                          7044


<210>  5093
<211>  897
<212>  PRT
<213>  Homo sapiens

<400>  5093

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu 
    530                 535                 540


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
545                 550                 555                 560


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
                565                 570                 575


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
            580                 585                 590


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
        595                 600                 605


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
    610                 615                 620


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
625                 630                 635                 640


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
                645                 650                 655


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
            660                 665                 670


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
        675                 680                 685


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
    690                 695                 700


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
705                 710                 715                 720


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
                725                 730                 735


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
            740                 745                 750


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
        755                 760                 765


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
    770                 775                 780


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
785                 790                 795                 800


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
                805                 810                 815


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
            820                 825                 830


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
        835                 840                 845


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
    850                 855                 860


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
865                 870                 875                 880


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
                885                 890                 895


Arg 



<210>  5094
<211>  7744
<212>  DNA
<213>  Homo sapiens

<400>  5094
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1080

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1140

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1200

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1260

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1320

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1380

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1440

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1500

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1560

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1620

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1680

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1740

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1800

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1860

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1920

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   1980

taccatatcc tgtgtttgaa tcaaacccgg agttcttgaa aggatcgtcc gcgggagtaa   2040

taaaatcaag ttcgttgtta aaaaacctga actagttatt tcctacttgc ctcctgggat   2100

ggctagtaaa ataaacacta aagctttgca gtcccccaaa agaccacgaa gtcctgggag   2160

taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc cctaataaca acaatcctca   2220

aacctcagct gttcgaaccc cgacccagac taacggttct aacgttccct tcaagccacg   2280

agggagagag ttttcctttg aggcctggaa tgccaaaatc acggacctaa aacagaaagt   2340

tgaaaatctc ttcaatgaga aatgtgggga agctcttggc cttaaacaag ctgtgaaggt   2400

gccgttcgcg ttatttgagt ctttcccgga agacttttat gtggaaggct tacctgaggg   2460

tgtgccattc cgaagaccat cgacttttgg cattccgagg ctggagaaga tactcagaaa   2520

caaagccaaa attaagttca tcattaaaaa gcccgaaatg tttgagacgg cgattaagga   2580

gagcacctcc tctaagagcc ctcccagaaa aataaattca tcacccaatg ttaatactac   2640

tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca attccagatg atgataatga   2700

aagactctcg aaagttgaaa aagctagaca gctaagagaa caagtgaatg acctctttag   2760

tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg aaagttccct acaggaaaat   2820

cacaattaac cctggctgtg tggtggttga tggcatgccc ccgggggtgt ccttcaaagc   2880

ccccagctac ctggaaatca gctccatgag aaggatctta gactctgccg agtttatcaa   2940

attcacggtc attaggtaag tgagagtttc ctgcttagtc acaggagcga atctggagct   3000

catgaggctg actcttctaa aatgcagcca caggtagtca tcgaatccgg cttcctatgc   3060

tgtgcaatca acaaatcaaa ataacttgtg tcatcattag aatgtcagat gtgcttctac   3120

gaactaagct gactctttta attctttggc aaagggttgg caaactagga ctgtttgcca   3180

aattcaggct gcctcctatt tttagagtct tcctgaaaca cagctacacc cgtattatcc   3240

atggctgctt tcctgtcaca gtgagtaagt agctgggact gagaaggcat ggcctccaaa   3300

gtctaaaata tttactctct agcactttgt agaaaaacct tagctaggca cagtggctaa   3360

cgcctgtaat cccagcattt tgggaggcca aggcaggcag atcacctgag gtcaggagtt   3420

ccagaccagc ctggccaaca tggtgaaatc ccatctctac aaaaataaaa cagttagctg   3480

ggcatgatgg cgggtgcctg taatcccagc tactcgggag gctgaggcag gatagtcgct   3540

tgaacccagg aggtggaggt tgcaatgagc caagatcatg ccactgcact ccagcctgga   3600

cgacagagtg agactccatc acaagaaaaa aagaactttg tcaacctctg tcttagggcg   3660

ccttgtcaca ggcttcgggt cagacggatt caaccttgca tcagccattt gttagccagg   3720

tcactctgtt ctttgtctgt aaatgagatt gatcgttgtt cccactgaga gtgtcagctc   3780

cttcccgtag agcaggcatg atgattgtac tcacctctga caccattgtg agtgccacat   3840

tccttcccac gtccttgtca ctgtaagaga tgcccacctg agcaccaacc ccaggttatc   3900

ttcccctttg tcttccagcc ccccagaaac agctacgact caacctaccc aatcatttca   3960

tcatcagatt gccactgtct ctagttcagg tctcttggga ctggcactca gaaatctcat   4020

aataaatcct cttgaggctt ctcatacact cgtcttcttc caatcttctt tccctcaaaa   4080

tctcatattt tggttccact tcacccaccg tcattctcca tatcactccc aggagttagg   4140

caaaaagccc cttccgttct tccgtatgtt aaacttagaa tcactctgtt ccctgctctg   4200

cgtttctatt ttttgttttt cctccattta ctagtagctt aacactttct aacagtgttc   4260

ttattattga tacgtatcta tctcttccat aagcttataa ggtcacggat aatacttctc   4320

attgtagtac gtaaatgacg tgggctagat atgagttgaa taaacagtta tacctgtaaa   4380

ttcttacaga gtgaaaataa attgttatac tttacaattt gtttctctct ttagaccatt   4440

tccaggactt gtgattaata accgtgagta ttttgtgaag tgttttgttt ttgttttttc   4500

ctggggtctg acgtgtgtgc gtgtgagtgt gtatacatgc ttaacgtata tcacgttact   4560

tcacctatgt cagtaaccag gccaaatact tgttttagcc ctcagtaaaa acaccaggca   4620

cttcctagtt gtaaaattat tcaagcttct taacttccta tcctcgatgc acttaatcat   4680

aaaatggtaa taatagcacc gattttgggg gagtcgttcc agtagatgga aagcatctgg   4740

aacaggtgtc agcaagctcc tgccgacgtg tatgcataaa gttttattga aaccaccatc   4800

gtgtccattt gtttatggca gaactgagag atggcagcag caagtgtgtg cctgcaaaac   4860

ctaaaatatt tactaattgg ctctgcaaga aaagagtttg catcccccta acctagaaca   4920

gtgtctagcc tctagtatgt gtttagccta cagtatgtgc tcagcgaata caatctatat   4980

ttattactgc ttttatgact gttataatta ctgtgcttgg atttcgttac aaagtaagtc   5040

acaatgtgcc tgcttctgtt agtatttcag cacagtgcct ggcacacatg gggctctcaa   5100

atattgctga gcgagtgaac aaatgtcctt tcaattcctt aacgttgatg tcattttcaa   5160

tagtattttg agccaaactt aattttgcga gtgtgttttg ttttcttaac tttattatta   5220

aaaatgtata aaagtgaggc caggcgtggt ggctcacgcc tgtaatccca gcagtttggg   5280

aggctgaggc aggcggatca gttgaggttg ggagttggag accagcccgt ccaacatggt   5340

gaaagcctgt ctctactaaa aatacaaaaa tcagctgggt gtggtggcgc gtgcctgtaa   5400

tcccagctac tcaggaggct gaggcaggag agttgcttga atcctagagg tggaggttgc   5460

agtgagctga gatcgtgcca ttgcactcca gcctgggcaa caagagcaaa actctgtccc   5520

aataaataaa taaataaaat gttctctttt gttcctgttc ttgtgcggta gtgtggtata   5580

gagttttatg gtaattactg tgaattagtg attctgaggg acatatcaga actctgaggt   5640

ttgtttcctt ctcatcttga gggaaacagc aaatgtatgt taaaatgctt ttccaaggga   5700

acaacacatc cttacattat ttaaaccaat ctgcttcatt ttcagagctg gttgatcaga   5760

gtgagtcaga aggccccgtg atacaagaat cagctgaacc aagccagttg gaagttccag   5820

ccacagaaga aataaaagag actgatggaa gctctcagat caagcaagaa ccagacccca   5880

cgtggtagac ctcttccctc ctagggtaaa tcagcttctg tgtcagggat gctgtgtggt   5940

gtccatctga accccctgca tacgcgtagc taatgtgatc tccccacttt cacataagat   6000

ggtggccctg ccttcaggga atgtgggagc caggtgggag ccttcccgga tatttaagct   6060

agaagattct acagggagat tctccttgga tcaatatatg tctctcagtc aaagatgtaa   6120

aagcactttt gccttaaaaa gaatgttctg tttctaaata gagtcaacgt tgtcctcctc   6180

attggaattc actatgagtc agaatcatta gactgacttt tttttttcca tagtaatagt   6240

attttgcaga gtctcacaga gctgcagatc ttttgttcat cttgcagagt taacaagtct   6300

gatcctgtta gtccagattt cttaaatttg gccaagttat aataggagca gtagcttgag   6360

acccgaagtc aggaaacttt gacaatggat tttttttttt aatccagaga cttgtactgg   6420

aatttgcctt accctgtcag ctcatggact taaggtttca tcccgcttta tgagtgcttc   6480

tgaatccaag tcattgttac ctgaatttgc aaattaagtt gtgatattcg tgactgttaa   6540

attcctgtaa ttagattaac ctctttgctt gcttgtttgt tttctctcct attttagctt   6600

aaagtatcag tggttgagaa gagcttttcg gacctgttac taccccaagc tgtgtaatat   6660

acttgtataa cagaaatacc ttctatacaa accttttttt ctacttttag atagaaatgt   6720

ctactttttc agcagttctg tgaattaaag agcagagtga ctgtgggtct ggaatggctg   6780

gtgtacttgg gaatgtacta tcaggatttt acagcaatgc tgggaaatga cagggaaaat   6840

gacaggaatg aatctcacca gattttttat gtactcagca gagccttgag ttacggtgtt   6900

tattttccaa tcaagtgaag atatctccta cttctcctac tggaacatct cagcttctgc   6960

agtgaagaaa aattcctgtg atagttcagt tctttagttt ttctatttga aaaaaaaaaa   7020

tcatttaaat gatcctttgt tcacggctct ccttaatgac tgagtgaaca gttcctatct   7080

gtatatttga ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt tttttatcat   7140

aattaaaagc aaaaccatct ggatcaccta acagtcagag gtcagtatct cagcgtgtga   7200

attatagagg aaatacagag agaacctctt ccacttttac ttttcgtcca aataaaatgc   7260

atggtgtacc agaagttgaa gatcgggttg aggattgggg ctagctcgat gacactaagg   7320

ccccaacatc gcgggacctg ctgtggcgcg gattcttagg aacgctgttc tagccggccc   7380

cctctccagg ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa ccctgaggtg   7440

ccagcgcggg gagtgaggag gggtcagggg gctaaggatg caacctctga cgttctgcgc   7500

cttcctagga gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc   7560

agctctacaa gaagctaggc tctgtgacgg catagttttc agtagcttta tcacaatatt   7620

cacaatggag aattatatga catggtagca gaaataggcc cttttatgtg ttgcttctat   7680

tttacctcaa attgtagata tagggtaatc aataaaatcc atccatgcct ttcacacact   7740

aagt                                                                7744


<210>  5095
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  5095

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala 
            580                 585                 590


Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600                 605


<210>  5096
<211>  4127
<212>  DNA
<213>  Homo sapiens

<400>  5096
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1980

catatcctgt gtttgaatca aacccggagt tcttgtatgt ggaaggcttg ccagagggga   2040

ttcccttccg aagccctacc tggtttggaa ttccacgact tgaaaggatc gtccgcggga   2100

gtaataaaat caagttcgtt gttaaaaaac ctgaactagt tatttcctac ttgcctcctg   2160

ggatggctag taaaataaac actaaagctt tgcagtcccc caaaagacca cgaagtcctg   2220

ggagtaattc aaaggttcct gaaattgagg tcaccgtgga aggccctaat aacaacaatc   2280

ctcaaacctc agctgttcga accccgaccc agactaacgg ttctaacgtt cccttcaagc   2340

cacgagggag agagttttcc tttgaggcct ggaatgccaa aatcacggac ctaaaacaga   2400

aagttgaaaa tctcttcaat gagaaatgtg gggaagctct tggccttaaa caagctgtga   2460

aggtgccgtt cgcgttattt gagtctttcc cggaagactt ttatgtggaa ggcttacctg   2520

agggtgtgcc attccgaaga ccatcgactt ttggcattcc gaggctggag aagatactca   2580

gaaacaaagc caaaattaag ttcatcatta aaaagcccga aatgtttgag acggcgatta   2640

aggagagcac ctcctctaag agccctccca gaaaaataaa ttcatcaccc aatgttaata   2700

ctactgcatc aggtgttgaa gaccttaaca tcattcaggt gacaattcca gatgatgata   2760

atgaaagact ctcgaaagtt gaaaaagcta gacagctaag agaacaagtg aatgacctct   2820

ttagtcggaa atttggtgaa gctattggta tgggttttcc tgtgaaagtt ccctacagga   2880

aaatcacaat taaccctggc tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca   2940

aagcccccag ctacctggaa atcagctcca tgagaaggat cttagactct gccgagttta   3000

tcaaattcac ggtcattaga ccatttccag gacttgtgat taataaccag ctggttgatc   3060

agagtgagtc agaaggcccc gtgatacaag aatcagctga accaagccag ttggaagttc   3120

cagccacaga agaaataaaa gagactgatg gaagctctca gatcaagcaa gaaccagacc   3180

ccacgtggta gacctcttcc ctcctaggct taaagtatca gtggttgaga agagcttttc   3240

ggacctgtta ctaccccaag ctgtagcctt gagttacggt gtttattttc caatcaagtg   3300

aagatatctc ctacttctcc tactggaaca tctcagcttc tgcagtgaag aaaaattcct   3360

gtgatagttc agttctttag tttttctatt tgaaaaaaaa aaatcattta aatgatcctt   3420

tgttcacggc tctccttaat gactgagtga acagttccta tctgtatatt tgactaaacc   3480

ttttcctaag ctatctctca tggttcctat gtttttttat cataattaaa agcaaaacca   3540

tctggatcac ctaacagtca gaggtcagta tctcagcgtg tgaattatag aggaaataca   3600

gagagaacct cttccacttt tacttttcgt ccaaataaaa tgcatggtgt accagaagtt   3660

gaagatcggg ttgaggattg gggctagctc gatgacacta aggccccaac atcgcgggac   3720

ctgctgtggc gcggattctt aggaacgctg ttctagccgg ccccctctcc aggggtcgcc   3780

gtggccggca ttatttccta gttcttcttg taaccctgag gtgccagcgc ggggagtgag   3840

gaggggtcag ggggctaagg atgcaacctc tgacgttctg cgccttccta ggagagtctt   3900

acatgtgttg agatttcaca agcaatgcga gttgtaaaat accagctcta caagaagcta   3960

ggctctgtga cggcatagtt ttcagtagct ttatcacaat attcacaatg gagaattata   4020

tgacatggta gcagaaatag gcccttttat gtgttgcttc tattttacct caaattgtag   4080

atatagggta atcaataaaa tccatccatg cctttcacac actaagt                 4127


<210>  5097
<211>  977
<212>  PRT
<213>  Homo sapiens

<400>  5097

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
                565                 570                 575


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
            580                 585                 590


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
        595                 600                 605


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
    610                 615                 620


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
625                 630                 635                 640


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
                645                 650                 655


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
            660                 665                 670


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
        675                 680                 685


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
    690                 695                 700


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
705                 710                 715                 720


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
                725                 730                 735


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
            740                 745                 750


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
        755                 760                 765


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
    770                 775                 780


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
785                 790                 795                 800


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
                805                 810                 815


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
            820                 825                 830


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
        835                 840                 845


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
    850                 855                 860


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
865                 870                 875                 880


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
                885                 890                 895


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
            900                 905                 910


Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile 
        915                 920                 925


Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln 
    930                 935                 940


Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile 
945                 950                 955                 960


Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr 
                965                 970                 975


Trp 



<210>  5098
<211>  4849
<212>  DNA
<213>  Homo sapiens

<400>  5098
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag    960

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1020

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1080

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1140

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1200

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1260

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1320

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1380

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1440

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1500

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1560

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1620

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1680

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1740

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagctc   1800

aagctcttgg actcaccgag gcagtaaaag taccatatcc tgtgtttgaa tcaaacccgg   1860

agttcttgta tgtggaaggc ttgccagagg ggattccctt ccgaagccct acctggtttg   1920

gaattccacg acttgaaagg atcgtccgcg ggagtaataa aatcaagttc gttgttaaaa   1980

aacctgaact agttatttcc tacttgcctc ctgggatggc tagtaaaata aacactaaag   2040

ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa ttcaaaggtt cctgaaattg   2100

aggtcaccgt ggaaggccct aataacaaca atcctcaaac ctcagctgtt cgaaccccga   2160

cccagactaa cggttctaac gttcccttca agccacgagg gagagagttt tcctttgagg   2220

cctggaatgc caaaatcacg gacctaaaac agaaagttga aaatctcttc aatgagaaat   2280

gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc gttcgcgtta tttgagtctt   2340

tcccggaaga cttttatgtg gaaggcttac ctgagggtgt gccattccga agaccatcga   2400

cttttggcat tccgaggctg gagaagatac tcagaaacaa agccaaaatt aagttcatca   2460

ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag cacctcctct aagagccctc   2520

ccagaaaaat aaattcatca cccaatgtta atactactgc atcaggtgtt gaagacctta   2580

acatcattca ggtgacaatt ccagatgatg ataatgaaag actctcgaaa gttgaaaaag   2640

ctagacagct aagagaacaa gtgaatgacc tctttagtcg gaaatttggt gaagctattg   2700

gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac aattaaccct ggctgtgtgg   2760

tggttgatgg catgcccccg ggggtgtcct tcaaagcccc cagctacctg gaaatcagct   2820

ccatgagaag gatcttagac tctgccgagt ttatcaaatt cacggtcatt agaccatttc   2880

caggacttgt gattaataac cagctggttg atcagagtga gtcagaaggc cccgtgatac   2940

aagaatcagc tgaaccaagc cagttggaag ttccagccac agaaggtaaa aggacctctt   3000

ccctcctagg gtaaatcagc ttctgtgtca gggatgctgt gtggtgtcca tctgaacccc   3060

ctgcatacgc gtagctaatg tgatctcccc actttcacat aagatggtgg ccctgccttc   3120

agggaatgtg ggagccaggt gggagccttc ccggatattt aagctagaag attctacagg   3180

gagattctcc ttggatcaat atatgtctct cagtcaaaga tgtaaaagca cttttgcctt   3240

aaaaagaatg ttctgtttct aaatagagtc aacgttgtcc tcctcattgg aattcactat   3300

gagtcagaat cattagactg actttttttt ttccatagta atagtatttt gcagagtctc   3360

acagagctgc agatcttttg ttcatcttgc agagttaaca agtctgatcc tgttagtcca   3420

gatttcttaa atttggccaa gttataatag gagcagtagc ttgagacccg aagtcaggaa   3480

actttgacaa tggatttttt tttttaatcc agagacttgt actggaattt gccttaccct   3540

gtcagctcat ggacttaagg tttcatcccg ctttatgagt gcttctgaat ccaagtcatt   3600

gttacctgaa tttgcaaatt aagttgtgat attcgtgact gttaaattcc tgtaattaga   3660

ttaacctctt tgcttgcttg tttgttttct ctcctatttt agcttaaagt atcagtggtt   3720

gagaagagct tttcggacct gttactaccc caagctgtgt aatatacttg tataacagaa   3780

ataccttcta tacaaacctt tttttctact tttagataga aatgtctact ttttcagcag   3840

ttctgtgaat taaagagcag agtgactgtg ggtctggaat ggctggtgta cttgggaatg   3900

tactatcagg attttacagc aatgctggga aatgacaggg aaaatgacag gaatgaatct   3960

caccagattt tttatgtact cagcagagcc ttgagttacg gtgtttattt tccaatcaag   4020

tgaagatatc tcctacttct cctactggaa catctcagct tctgcagtga agaaaaattc   4080

ctgtgatagt tcagttcttt agtttttcta tttgaaaaaa aaaaatcatt taaatgatcc   4140

tttgttcacg gctctcctta atgactgagt gaacagttcc tatctgtata tttgactaaa   4200

ccttttccta agctatctct catggttcct atgttttttt atcataatta aaagcaaaac   4260

catctggatc acctaacagt cagaggtcag tatctcagcg tgtgaattat agaggaaata   4320

cagagagaac ctcttccact tttacttttc gtccaaataa aatgcatggt gtaccagaag   4380

ttgaagatcg ggttgaggat tggggctagc tcgatgacac taaggcccca acatcgcggg   4440

acctgctgtg gcgcggattc ttaggaacgc tgttctagcc ggccccctct ccaggggtcg   4500

ccgtggccgg cattatttcc tagttcttct tgtaaccctg aggtgccagc gcggggagtg   4560

aggaggggtc agggggctaa ggatgcaacc tctgacgttc tgcgccttcc taggagagtc   4620

ttacatgtgt tgagatttca caagcaatgc gagttgtaaa ataccagctc tacaagaagc   4680

taggctctgt gacggcatag ttttcagtag ctttatcaca atattcacaa tggagaatta   4740

tatgacatgg tagcagaaat aggccctttt atgtgttgct tctattttac ctcaaattgt   4800

agatataggg taatcaataa aatccatcca tgcctttcac acactaagt               4849


<210>  5099
<211>  918
<212>  PRT
<213>  Homo sapiens

<400>  5099

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro 
        515                 520                 525


Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu 
    530                 535                 540


Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu 
545                 550                 555                 560


Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro 
                565                 570                 575


Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn 
            580                 585                 590


Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn 
        595                 600                 605


Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn 
    610                 615                 620


Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser 
625                 630                 635                 640


Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp 
                645                 650                 655


Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn 
            660                 665                 670


Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro 
        675                 680                 685


Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu 
    690                 695                 700


Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg 
705                 710                 715                 720


Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys 
                725                 730                 735


Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys 
            740                 745                 750


Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala 
        755                 760                 765


Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp 
    770                 775                 780


Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu 
785                 790                 795                 800


Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met 
                805                 810                 815


Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly 
            820                 825                 830


Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro 
        835                 840                 845


Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu 
    850                 855                 860


Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn 
865                 870                 875                 880


Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu 
                885                 890                 895


Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Gly Lys Arg 
            900                 905                 910


Thr Ser Ser Leu Leu Gly 
        915


<210>  5100
<211>  4854
<212>  DNA
<213>  Homo sapiens

<400>  5100
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag    960

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1020

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1080

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1140

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1200

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1260

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1320

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1380

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1440

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1500

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1560

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1620

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1680

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1740

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1800

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1860

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1920

aatcaaaccc ggagttcttg aaaggatcgt ccgcgggagt aataaaatca agttcgttgt   1980

taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta aaataaacac   2040

taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa aggttcctga   2100

aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag ctgttcgaac   2160

cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag agttttcctt   2220

tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc tcttcaatga   2280

gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg cgttatttga   2340

gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat tccgaagacc   2400

atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca aaattaagtt   2460

catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct cctctaagag   2520

ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag gtgttgaaga   2580

ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct cgaaagttga   2640

aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat ttggtgaagc   2700

tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta accctggctg   2760

tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct acctggaaat   2820

cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg tcattagacc   2880

atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag aaggccccgt   2940

gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag gtaaaaggac   3000

ctcttccctc ctagggtaaa tcagcttctg tgtcagggat gctgtgtggt gtccatctga   3060

accccctgca tacgcgtagc taatgtgatc tccccacttt cacataagat ggtggccctg   3120

ccttcaggga atgtgggagc caggtgggag ccttcccgga tatttaagct agaagattct   3180

acagggagat tctccttgga tcaatatatg tctctcagtc aaagatgtaa aagcactttt   3240

gccttaaaaa gaatgttctg tttctaaata gagtcaacgt tgtcctcctc attggaattc   3300

actatgagtc agaatcatta gactgacttt tttttttcca tagtaatagt attttgcaga   3360

gtctcacaga gctgcagatc ttttgttcat cttgcagagt taacaagtct gatcctgtta   3420

gtccagattt cttaaatttg gccaagttat aataggagca gtagcttgag acccgaagtc   3480

aggaaacttt gacaatggat tttttttttt aatccagaga cttgtactgg aatttgcctt   3540

accctgtcag ctcatggact taaggtttca tcccgcttta tgagtgcttc tgaatccaag   3600

tcattgttac ctgaatttgc aaattaagtt gtgatattcg tgactgttaa attcctgtaa   3660

ttagattaac ctctttgctt gcttgtttgt tttctctcct attttagctt aaagtatcag   3720

tggttgagaa gagcttttcg gacctgttac taccccaagc tgtgtaatat acttgtataa   3780

cagaaatacc ttctatacaa accttttttt ctacttttag atagaaatgt ctactttttc   3840

agcagttctg tgaattaaag agcagagtga ctgtgggtct ggaatggctg gtgtacttgg   3900

gaatgtacta tcaggatttt acagcaatgc tgggaaatga cagggaaaat gacaggaatg   3960

aatctcacca gattttttat gtactcagca gagccttgag ttacggtgtt tattttccaa   4020

tcaagtgaag atatctccta cttctcctac tggaacatct cagcttctgc agtgaagaaa   4080

aattcctgtg atagttcagt tctttagttt ttctatttga aaaaaaaaaa tcatttaaat   4140

gatcctttgt tcacggctct ccttaatgac tgagtgaaca gttcctatct gtatatttga   4200

ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt tttttatcat aattaaaagc   4260

aaaaccatct ggatcaccta acagtcagag gtcagtatct cagcgtgtga attatagagg   4320

aaatacagag agaacctctt ccacttttac ttttcgtcca aataaaatgc atggtgtacc   4380

agaagttgaa gatcgggttg aggattgggg ctagctcgat gacactaagg ccccaacatc   4440

gcgggacctg ctgtggcgcg gattcttagg aacgctgttc tagccggccc cctctccagg   4500

ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa ccctgaggtg ccagcgcggg   4560

gagtgaggag gggtcagggg gctaaggatg caacctctga cgttctgcgc cttcctagga   4620

gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc agctctacaa   4680

gaagctaggc tctgtgacgg catagttttc agtagcttta tcacaatatt cacaatggag   4740

aattatatga catggtagca gaaataggcc cttttatgtg ttgcttctat tttacctcaa   4800

attgtagata tagggtaatc aataaaatcc atccatgcct ttcacacact aagt         4854


<210>  5101
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  5101

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys 
                565                 570                 575


Asn Leu Asn 



<210>  5102
<211>  7666
<212>  DNA
<213>  Homo sapiens

<400>  5102
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag    960

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1020

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1080

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1140

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1200

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1260

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1320

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1380

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1440

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1500

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1560

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1620

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1680

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1740

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1800

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1860

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1920

aatcaaaccc ggagttcttg aaaggatcgt ccgcgggagt aataaaatca agttcgttgt   1980

taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta aaataaacac   2040

taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa aggttcctga   2100

aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag ctgttcgaac   2160

cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag agttttcctt   2220

tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc tcttcaatga   2280

gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg cgttatttga   2340

gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat tccgaagacc   2400

atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca aaattaagtt   2460

catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct cctctaagag   2520

ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag gtgttgaaga   2580

ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct cgaaagttga   2640

aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat ttggtgaagc   2700

tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta accctggctg   2760

tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct acctggaaat   2820

cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg tcattaggta   2880

agtgagagtt tcctgcttag tcacaggagc gaatctggag ctcatgaggc tgactcttct   2940

aaaatgcagc cacaggtagt catcgaatcc ggcttcctat gctgtgcaat caacaaatca   3000

aaataacttg tgtcatcatt agaatgtcag atgtgcttct acgaactaag ctgactcttt   3060

taattctttg gcaaagggtt ggcaaactag gactgtttgc caaattcagg ctgcctccta   3120

tttttagagt cttcctgaaa cacagctaca cccgtattat ccatggctgc tttcctgtca   3180

cagtgagtaa gtagctggga ctgagaaggc atggcctcca aagtctaaaa tatttactct   3240

ctagcacttt gtagaaaaac cttagctagg cacagtggct aacgcctgta atcccagcat   3300

tttgggaggc caaggcaggc agatcacctg aggtcaggag ttccagacca gcctggccaa   3360

catggtgaaa tcccatctct acaaaaataa aacagttagc tgggcatgat ggcgggtgcc   3420

tgtaatccca gctactcggg aggctgaggc aggatagtcg cttgaaccca ggaggtggag   3480

gttgcaatga gccaagatca tgccactgca ctccagcctg gacgacagag tgagactcca   3540

tcacaagaaa aaaagaactt tgtcaacctc tgtcttaggg cgccttgtca caggcttcgg   3600

gtcagacgga ttcaaccttg catcagccat ttgttagcca ggtcactctg ttctttgtct   3660

gtaaatgaga ttgatcgttg ttcccactga gagtgtcagc tccttcccgt agagcaggca   3720

tgatgattgt actcacctct gacaccattg tgagtgccac attccttccc acgtccttgt   3780

cactgtaaga gatgcccacc tgagcaccaa ccccaggtta tcttcccctt tgtcttccag   3840

ccccccagaa acagctacga ctcaacctac ccaatcattt catcatcaga ttgccactgt   3900

ctctagttca ggtctcttgg gactggcact cagaaatctc ataataaatc ctcttgaggc   3960

ttctcataca ctcgtcttct tccaatcttc tttccctcaa aatctcatat tttggttcca   4020

cttcacccac cgtcattctc catatcactc ccaggagtta ggcaaaaagc cccttccgtt   4080

cttccgtatg ttaaacttag aatcactctg ttccctgctc tgcgtttcta ttttttgttt   4140

ttcctccatt tactagtagc ttaacacttt ctaacagtgt tcttattatt gatacgtatc   4200

tatctcttcc ataagcttat aaggtcacgg ataatacttc tcattgtagt acgtaaatga   4260

cgtgggctag atatgagttg aataaacagt tatacctgta aattcttaca gagtgaaaat   4320

aaattgttat actttacaat ttgtttctct ctttagacca tttccaggac ttgtgattaa   4380

taaccgtgag tattttgtga agtgttttgt ttttgttttt tcctggggtc tgacgtgtgt   4440

gcgtgtgagt gtgtatacat gcttaacgta tatcacgtta cttcacctat gtcagtaacc   4500

aggccaaata cttgttttag ccctcagtaa aaacaccagg cacttcctag ttgtaaaatt   4560

attcaagctt cttaacttcc tatcctcgat gcacttaatc ataaaatggt aataatagca   4620

ccgattttgg gggagtcgtt ccagtagatg gaaagcatct ggaacaggtg tcagcaagct   4680

cctgccgacg tgtatgcata aagttttatt gaaaccacca tcgtgtccat ttgtttatgg   4740

cagaactgag agatggcagc agcaagtgtg tgcctgcaaa acctaaaata tttactaatt   4800

ggctctgcaa gaaaagagtt tgcatccccc taacctagaa cagtgtctag cctctagtat   4860

gtgtttagcc tacagtatgt gctcagcgaa tacaatctat atttattact gcttttatga   4920

ctgttataat tactgtgctt ggatttcgtt acaaagtaag tcacaatgtg cctgcttctg   4980

ttagtatttc agcacagtgc ctggcacaca tggggctctc aaatattgct gagcgagtga   5040

acaaatgtcc tttcaattcc ttaacgttga tgtcattttc aatagtattt tgagccaaac   5100

ttaattttgc gagtgtgttt tgttttctta actttattat taaaaatgta taaaagtgag   5160

gccaggcgtg gtggctcacg cctgtaatcc cagcagtttg ggaggctgag gcaggcggat   5220

cagttgaggt tgggagttgg agaccagccc gtccaacatg gtgaaagcct gtctctacta   5280

aaaatacaaa aatcagctgg gtgtggtggc gcgtgcctgt aatcccagct actcaggagg   5340

ctgaggcagg agagttgctt gaatcctaga ggtggaggtt gcagtgagct gagatcgtgc   5400

cattgcactc cagcctgggc aacaagagca aaactctgtc ccaataaata aataaataaa   5460

atgttctctt ttgttcctgt tcttgtgcgg tagtgtggta tagagtttta tggtaattac   5520

tgtgaattag tgattctgag ggacatatca gaactctgag gtttgtttcc ttctcatctt   5580

gagggaaaca gcaaatgtat gttaaaatgc ttttccaagg gaacaacaca tccttacatt   5640

atttaaacca atctgcttca ttttcagagc tggttgatca gagtgagtca gaaggccccg   5700

tgatacaaga atcagctgaa ccaagccagt tggaagttcc agccacagaa gaaataaaag   5760

agactgatgg aagctctcag atcaagcaag aaccagaccc cacgtggtag acctcttccc   5820

tcctagggta aatcagcttc tgtgtcaggg atgctgtgtg gtgtccatct gaaccccctg   5880

catacgcgta gctaatgtga tctccccact ttcacataag atggtggccc tgccttcagg   5940

gaatgtggga gccaggtggg agccttcccg gatatttaag ctagaagatt ctacagggag   6000

attctccttg gatcaatata tgtctctcag tcaaagatgt aaaagcactt ttgccttaaa   6060

aagaatgttc tgtttctaaa tagagtcaac gttgtcctcc tcattggaat tcactatgag   6120

tcagaatcat tagactgact tttttttttc catagtaata gtattttgca gagtctcaca   6180

gagctgcaga tcttttgttc atcttgcaga gttaacaagt ctgatcctgt tagtccagat   6240

ttcttaaatt tggccaagtt ataataggag cagtagcttg agacccgaag tcaggaaact   6300

ttgacaatgg attttttttt ttaatccaga gacttgtact ggaatttgcc ttaccctgtc   6360

agctcatgga cttaaggttt catcccgctt tatgagtgct tctgaatcca agtcattgtt   6420

acctgaattt gcaaattaag ttgtgatatt cgtgactgtt aaattcctgt aattagatta   6480

acctctttgc ttgcttgttt gttttctctc ctattttagc ttaaagtatc agtggttgag   6540

aagagctttt cggacctgtt actaccccaa gctgtgtaat atacttgtat aacagaaata   6600

ccttctatac aaaccttttt ttctactttt agatagaaat gtctactttt tcagcagttc   6660

tgtgaattaa agagcagagt gactgtgggt ctggaatggc tggtgtactt gggaatgtac   6720

tatcaggatt ttacagcaat gctgggaaat gacagggaaa atgacaggaa tgaatctcac   6780

cagatttttt atgtactcag cagagccttg agttacggtg tttattttcc aatcaagtga   6840

agatatctcc tacttctcct actggaacat ctcagcttct gcagtgaaga aaaattcctg   6900

tgatagttca gttctttagt ttttctattt gaaaaaaaaa aatcatttaa atgatccttt   6960

gttcacggct ctccttaatg actgagtgaa cagttcctat ctgtatattt gactaaacct   7020

tttcctaagc tatctctcat ggttcctatg tttttttatc ataattaaaa gcaaaaccat   7080

ctggatcacc taacagtcag aggtcagtat ctcagcgtgt gaattataga ggaaatacag   7140

agagaacctc ttccactttt acttttcgtc caaataaaat gcatggtgta ccagaagttg   7200

aagatcgggt tgaggattgg ggctagctcg atgacactaa ggccccaaca tcgcgggacc   7260

tgctgtggcg cggattctta ggaacgctgt tctagccggc cccctctcca ggggtcgccg   7320

tggccggcat tatttcctag ttcttcttgt aaccctgagg tgccagcgcg gggagtgagg   7380

aggggtcagg gggctaagga tgcaacctct gacgttctgc gccttcctag gagagtctta   7440

catgtgttga gatttcacaa gcaatgcgag ttgtaaaata ccagctctac aagaagctag   7500

gctctgtgac ggcatagttt tcagtagctt tatcacaata ttcacaatgg agaattatat   7560

gacatggtag cagaaatagg cccttttatg tgttgcttct attttacctc aaattgtaga   7620

tatagggtaa tcaataaaat ccatccatgc ctttcacaca ctaagt                  7666


<210>  5103
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  5103

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys 
                565                 570                 575


Asn Leu Asn 



<210>  5104
<211>  4470
<212>  DNA
<213>  Homo sapiens

<400>  5104
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1080

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1140

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1200

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1260

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1320

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1380

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1440

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1500

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1560

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1620

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1680

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1740

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1800

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1860

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1920

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   1980

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2040

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2100

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2160

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2220

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2280

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2340

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2400

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2460

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2520

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2580

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2640

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2700

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2760

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2820

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   2880

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   2940

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3000

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3060

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3120

ttcacggtca ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt   3180

gagtcagaag gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc   3240

acagaagaaa taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg   3300

tggtagacct cttccctcct aggcttaaag tatcagtggt tgagaagagc ttttcggacc   3360

tgttactacc ccaagctgtg taatatactt gtataacaga aataccttct atacaaacct   3420

ttttttctac ttttagatag aaatgtctac tttttcagca gttctgtgaa ttaaagagca   3480

gagtgactgt gggtctggaa tggctggtgt acttgggaat gtactatcag gattttacag   3540

caatgctggg aaatgacagg gaaaatgaca ggaatgaatc tcaccagatt ttttatgtac   3600

tcagcagagc cttgagttac ggtgtttatt ttccaatcaa gtgaagatat ctcctacttc   3660

tcctactgga acatctcagc ttctgcagtg aagaaaaatt cctgtgatag ttcagttctt   3720

tagtttttct atttgaaaaa aaaaaatcat ttaaatgatc ctttgttcac ggctctcctt   3780

aatgactgag tgaacagttc ctatctgtat atttgactaa accttttcct aagctatctc   3840

tcatggttcc tatgtttttt tatcataatt aaaagcaaaa ccatctggat cacctaacag   3900

tcagaggtca gtatctcagc gtgtgaatta tagaggaaat acagagagaa cctcttccac   3960

ttttactttt cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc gggttgagga   4020

ttggggctag ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt ggcgcggatt   4080

cttaggaacg ctgttctagc cggccccctc tccaggggtc gccgtggccg gcattatttc   4140

ctagttcttc ttgtaaccct gaggtgccag cgcggggagt gaggaggggt cagggggcta   4200

aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg ttgagatttc   4260

acaagcaatg cgagttgtaa aataccagct ctacaagaag ctaggctctg tgacggcata   4320

gttttcagta gctttatcac aatattcaca atggagaatt atatgacatg gtagcagaaa   4380

taggcccttt tatgtgttgc ttctatttta cctcaaattg tagatatagg gtaatcaata   4440

aaatccatcc atgcctttca cacactaagt                                    4470


<210>  5105
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  5105

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala 



<210>  5106
<211>  5159
<212>  DNA
<213>  Homo sapiens

<400>  5106
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgcttaga tttgttgaca gcggtttcct ggagtgctgt   1980

cttgagaacg attctgagga ggctcagcaa gaaagagtgt ttcagttgat tgggtgtgtc   2040

tgtcatggag aaggaactca agctcttgga ctcaccgagg cagtaaaagt accatatcct   2100

gtgtttgaat caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc   2160

cgaagcccta cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa   2220

atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct   2280

agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat   2340

tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc   2400

tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg   2460

agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa   2520

aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg   2580

ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg   2640

ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa   2700

gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc   2760

acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca   2820

tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga   2880

ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg   2940

aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca   3000

attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt caaagccccc   3060

agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc   3120

acggtcatta gaccatttcc aggacttgtg attaataacc agctggttga tcagagtgag   3180

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   3240

gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga ccccacgtgg   3300

tagacctctt ccctcctagg gtaaatcagc ttctgtgtca gggatgctgt gtggtgtcca   3360

tctgaacccc ctgcatacgc gtagctaatg tgatctcccc actttcacat aagatggtgg   3420

ccctgccttc agggaatgtg ggagccaggt gggagccttc ccggatattt aagctagaag   3480

attctacagg gagattctcc ttggatcaat atatgtctct cagtcaaaga tgtaaaagca   3540

cttttgcctt aaaaagaatg ttctgtttct aaatagagtc aacgttgtcc tcctcattgg   3600

aattcactat gagtcagaat cattagactg actttttttt ttccatagta atagtatttt   3660

gcagagtctc acagagctgc agatcttttg ttcatcttgc agagttaaca agtctgatcc   3720

tgttagtcca gatttcttaa atttggccaa gttataatag gagcagtagc ttgagacccg   3780

aagtcaggaa actttgacaa tggatttttt tttttaatcc agagacttgt actggaattt   3840

gccttaccct gtcagctcat ggacttaagg tttcatcccg ctttatgagt gcttctgaat   3900

ccaagtcatt gttacctgaa tttgcaaatt aagttgtgat attcgtgact gttaaattcc   3960

tgtaattaga ttaacctctt tgcttgcttg tttgttttct ctcctatttt agcttaaagt   4020

atcagtggtt gagaagagct tttcggacct gttactaccc caagctgtgt aatatacttg   4080

tataacagaa ataccttcta tacaaacctt tttttctact tttagataga aatgtctact   4140

ttttcagcag ttctgtgaat taaagagcag agtgactgtg ggtctggaat ggctggtgta   4200

cttgggaatg tactatcagg attttacagc aatgctggga aatgacaggg aaaatgacag   4260

gaatgaatct caccagattt tttatgtact cagcagagcc ttgagttacg gtgtttattt   4320

tccaatcaag tgaagatatc tcctacttct cctactggaa catctcagct tctgcagtga   4380

agaaaaattc ctgtgatagt tcagttcttt agtttttcta tttgaaaaaa aaaaatcatt   4440

taaatgatcc tttgttcacg gctctcctta atgactgagt gaacagttcc tatctgtata   4500

tttgactaaa ccttttccta agctatctct catggttcct atgttttttt atcataatta   4560

aaagcaaaac catctggatc acctaacagt cagaggtcag tatctcagcg tgtgaattat   4620

agaggaaata cagagagaac ctcttccact tttacttttc gtccaaataa aatgcatggt   4680

gtaccagaag ttgaagatcg ggttgaggat tggggctagc tcgatgacac taaggcccca   4740

acatcgcggg acctgctgtg gcgcggattc ttaggaacgc tgttctagcc ggccccctct   4800

ccaggggtcg ccgtggccgg cattatttcc tagttcttct tgtaaccctg aggtgccagc   4860

gcggggagtg aggaggggtc agggggctaa ggatgcaacc tctgacgttc tgcgccttcc   4920

taggagagtc ttacatgtgt tgagatttca caagcaatgc gagttgtaaa ataccagctc   4980

tacaagaagc taggctctgt gacggcatag ttttcagtag ctttatcaca atattcacaa   5040

tggagaatta tatgacatgg tagcagaaat aggccctttt atgtgttgct tctattttac   5100

ctcaaattgt agatataggg taatcaataa aatccatcca tgcctttcac acactaagt    5159


<210>  5107
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  5107

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala 



<210>  5108
<211>  7739
<212>  DNA
<213>  Homo sapiens

<400>  5108
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1080

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1140

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1200

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1260

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1320

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1380

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1440

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1500

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1560

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1620

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1680

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1740

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1800

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1860

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   1920

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   1980

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2040

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2100

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2160

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2220

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2280

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2340

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2400

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2460

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2520

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2580

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2640

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2700

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2760

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2820

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   2880

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   2940

cggtcattag gtaagtgaga gtttcctgct tagtcacagg agcgaatctg gagctcatga   3000

ggctgactct tctaaaatgc agccacaggt agtcatcgaa tccggcttcc tatgctgtgc   3060

aatcaacaaa tcaaaataac ttgtgtcatc attagaatgt cagatgtgct tctacgaact   3120

aagctgactc ttttaattct ttggcaaagg gttggcaaac taggactgtt tgccaaattc   3180

aggctgcctc ctatttttag agtcttcctg aaacacagct acacccgtat tatccatggc   3240

tgctttcctg tcacagtgag taagtagctg ggactgagaa ggcatggcct ccaaagtcta   3300

aaatatttac tctctagcac tttgtagaaa aaccttagct aggcacagtg gctaacgcct   3360

gtaatcccag cattttggga ggccaaggca ggcagatcac ctgaggtcag gagttccaga   3420

ccagcctggc caacatggtg aaatcccatc tctacaaaaa taaaacagtt agctgggcat   3480

gatggcgggt gcctgtaatc ccagctactc gggaggctga ggcaggatag tcgcttgaac   3540

ccaggaggtg gaggttgcaa tgagccaaga tcatgccact gcactccagc ctggacgaca   3600

gagtgagact ccatcacaag aaaaaaagaa ctttgtcaac ctctgtctta gggcgccttg   3660

tcacaggctt cgggtcagac ggattcaacc ttgcatcagc catttgttag ccaggtcact   3720

ctgttctttg tctgtaaatg agattgatcg ttgttcccac tgagagtgtc agctccttcc   3780

cgtagagcag gcatgatgat tgtactcacc tctgacacca ttgtgagtgc cacattcctt   3840

cccacgtcct tgtcactgta agagatgccc acctgagcac caaccccagg ttatcttccc   3900

ctttgtcttc cagcccccca gaaacagcta cgactcaacc tacccaatca tttcatcatc   3960

agattgccac tgtctctagt tcaggtctct tgggactggc actcagaaat ctcataataa   4020

atcctcttga ggcttctcat acactcgtct tcttccaatc ttctttccct caaaatctca   4080

tattttggtt ccacttcacc caccgtcatt ctccatatca ctcccaggag ttaggcaaaa   4140

agccccttcc gttcttccgt atgttaaact tagaatcact ctgttccctg ctctgcgttt   4200

ctattttttg tttttcctcc atttactagt agcttaacac tttctaacag tgttcttatt   4260

attgatacgt atctatctct tccataagct tataaggtca cggataatac ttctcattgt   4320

agtacgtaaa tgacgtgggc tagatatgag ttgaataaac agttatacct gtaaattctt   4380

acagagtgaa aataaattgt tatactttac aatttgtttc tctctttaga ccatttccag   4440

gacttgtgat taataaccgt gagtattttg tgaagtgttt tgtttttgtt ttttcctggg   4500

gtctgacgtg tgtgcgtgtg agtgtgtata catgcttaac gtatatcacg ttacttcacc   4560

tatgtcagta accaggccaa atacttgttt tagccctcag taaaaacacc aggcacttcc   4620

tagttgtaaa attattcaag cttcttaact tcctatcctc gatgcactta atcataaaat   4680

ggtaataata gcaccgattt tgggggagtc gttccagtag atggaaagca tctggaacag   4740

gtgtcagcaa gctcctgccg acgtgtatgc ataaagtttt attgaaacca ccatcgtgtc   4800

catttgttta tggcagaact gagagatggc agcagcaagt gtgtgcctgc aaaacctaaa   4860

atatttacta attggctctg caagaaaaga gtttgcatcc ccctaaccta gaacagtgtc   4920

tagcctctag tatgtgttta gcctacagta tgtgctcagc gaatacaatc tatatttatt   4980

actgctttta tgactgttat aattactgtg cttggatttc gttacaaagt aagtcacaat   5040

gtgcctgctt ctgttagtat ttcagcacag tgcctggcac acatggggct ctcaaatatt   5100

gctgagcgag tgaacaaatg tcctttcaat tccttaacgt tgatgtcatt ttcaatagta   5160

ttttgagcca aacttaattt tgcgagtgtg ttttgttttc ttaactttat tattaaaaat   5220

gtataaaagt gaggccaggc gtggtggctc acgcctgtaa tcccagcagt ttgggaggct   5280

gaggcaggcg gatcagttga ggttgggagt tggagaccag cccgtccaac atggtgaaag   5340

cctgtctcta ctaaaaatac aaaaatcagc tgggtgtggt ggcgcgtgcc tgtaatccca   5400

gctactcagg aggctgaggc aggagagttg cttgaatcct agaggtggag gttgcagtga   5460

gctgagatcg tgccattgca ctccagcctg ggcaacaaga gcaaaactct gtcccaataa   5520

ataaataaat aaaatgttct cttttgttcc tgttcttgtg cggtagtgtg gtatagagtt   5580

ttatggtaat tactgtgaat tagtgattct gagggacata tcagaactct gaggtttgtt   5640

tccttctcat cttgagggaa acagcaaatg tatgttaaaa tgcttttcca agggaacaac   5700

acatccttac attatttaaa ccaatctgct tcattttcag agctggttga tcagagtgag   5760

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   5820

gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga ccccacgtgg   5880

tagacctctt ccctcctagg gtaaatcagc ttctgtgtca gggatgctgt gtggtgtcca   5940

tctgaacccc ctgcatacgc gtagctaatg tgatctcccc actttcacat aagatggtgg   6000

ccctgccttc agggaatgtg ggagccaggt gggagccttc ccggatattt aagctagaag   6060

attctacagg gagattctcc ttggatcaat atatgtctct cagtcaaaga tgtaaaagca   6120

cttttgcctt aaaaagaatg ttctgtttct aaatagagtc aacgttgtcc tcctcattgg   6180

aattcactat gagtcagaat cattagactg actttttttt ttccatagta atagtatttt   6240

gcagagtctc acagagctgc agatcttttg ttcatcttgc agagttaaca agtctgatcc   6300

tgttagtcca gatttcttaa atttggccaa gttataatag gagcagtagc ttgagacccg   6360

aagtcaggaa actttgacaa tggatttttt tttttaatcc agagacttgt actggaattt   6420

gccttaccct gtcagctcat ggacttaagg tttcatcccg ctttatgagt gcttctgaat   6480

ccaagtcatt gttacctgaa tttgcaaatt aagttgtgat attcgtgact gttaaattcc   6540

tgtaattaga ttaacctctt tgcttgcttg tttgttttct ctcctatttt agcttaaagt   6600

atcagtggtt gagaagagct tttcggacct gttactaccc caagctgtgt aatatacttg   6660

tataacagaa ataccttcta tacaaacctt tttttctact tttagataga aatgtctact   6720

ttttcagcag ttctgtgaat taaagagcag agtgactgtg ggtctggaat ggctggtgta   6780

cttgggaatg tactatcagg attttacagc aatgctggga aatgacaggg aaaatgacag   6840

gaatgaatct caccagattt tttatgtact cagcagagcc ttgagttacg gtgtttattt   6900

tccaatcaag tgaagatatc tcctacttct cctactggaa catctcagct tctgcagtga   6960

agaaaaattc ctgtgatagt tcagttcttt agtttttcta tttgaaaaaa aaaaatcatt   7020

taaatgatcc tttgttcacg gctctcctta atgactgagt gaacagttcc tatctgtata   7080

tttgactaaa ccttttccta agctatctct catggttcct atgttttttt atcataatta   7140

aaagcaaaac catctggatc acctaacagt cagaggtcag tatctcagcg tgtgaattat   7200

agaggaaata cagagagaac ctcttccact tttacttttc gtccaaataa aatgcatggt   7260

gtaccagaag ttgaagatcg ggttgaggat tggggctagc tcgatgacac taaggcccca   7320

acatcgcggg acctgctgtg gcgcggattc ttaggaacgc tgttctagcc ggccccctct   7380

ccaggggtcg ccgtggccgg cattatttcc tagttcttct tgtaaccctg aggtgccagc   7440

gcggggagtg aggaggggtc agggggctaa ggatgcaacc tctgacgttc tgcgccttcc   7500

taggagagtc ttacatgtgt tgagatttca caagcaatgc gagttgtaaa ataccagctc   7560

tacaagaagc taggctctgt gacggcatag ttttcagtag ctttatcaca atattcacaa   7620

tggagaatta tatgacatgg tagcagaaat aggccctttt atgtgttgct tctattttac   7680

ctcaaattgt agatataggg taatcaataa aatccatcca tgcctttcac acactaagt    7739


<210>  5109
<211>  898
<212>  PRT
<213>  Homo sapiens

<400>  5109

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly 
    530                 535                 540


Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro 
545                 550                 555                 560


Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser 
                565                 570                 575


Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser 
            580                 585                 590


Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr 
        595                 600                 605


Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser 
    610                 615                 620


Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile 
625                 630                 635                 640


Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala 
                645                 650                 655


Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro 
            660                 665                 670


Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp 
        675                 680                 685


Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala 
    690                 695                 700


Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser 
705                 710                 715                 720


Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe 
                725                 730                 735


Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg 
            740                 745                 750


Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu 
        755                 760                 765


Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile 
    770                 775                 780


Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu 
785                 790                 795                 800


Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser 
                805                 810                 815


Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe 
            820                 825                 830


Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val 
        835                 840                 845


Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly 
    850                 855                 860


Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser 
865                 870                 875                 880


Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val 
                885                 890                 895


Ile Arg 



<210>  5110
<211>  4067
<212>  DNA
<213>  Homo sapiens

<400>  5110
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040

taccatatcc tgtgtttgaa tcaaacccgg agttcttgaa aggatcgtcc gcgggagtaa   2100

taaaatcaag ttcgttgtta aaaaacctga actagttatt tcctacttgc ctcctgggat   2160

ggctagtaaa ataaacacta aagctttgca gtcccccaaa agaccacgaa gtcctgggag   2220

taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc cctaataaca acaatcctca   2280

aacctcagct gttcgaaccc cgacccagac taacggttct aacgttccct tcaagccacg   2340

agggagagag ttttcctttg aggcctggaa tgccaaaatc acggacctaa aacagaaagt   2400

tgaaaatctc ttcaatgaga aatgtgggga agctcttggc cttaaacaag ctgtgaaggt   2460

gccgttcgcg ttatttgagt ctttcccgga agacttttat gtggaaggct tacctgaggg   2520

tgtgccattc cgaagaccat cgacttttgg cattccgagg ctggagaaga tactcagaaa   2580

caaagccaaa attaagttca tcattaaaaa gcccgaaatg tttgagacgg cgattaagga   2640

gagcacctcc tctaagagcc ctcccagaaa aataaattca tcacccaatg ttaatactac   2700

tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca attccagatg atgataatga   2760

aagactctcg aaagttgaaa aagctagaca gctaagagaa caagtgaatg acctctttag   2820

tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg aaagttccct acaggaaaat   2880

cacaattaac cctggctgtg tggtggttga tggcatgccc ccgggggtgt ccttcaaagc   2940

ccccagctac ctggaaatca gctccatgag aaggatctta gactctgccg agtttatcaa   3000

attcacggtc attagaccat ttccaggact tgtgattaat aaccagctgg ttgatcagag   3060

tgagtcagaa ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc   3120

cacagaagaa ataaaagaga ctgatggaag ctctcagatc aagcaagaac cagaccccac   3180

gtggtagacc tcttccctcc taggagcctt gagttacggt gtttattttc caatcaagtg   3240

aagatatctc ctacttctcc tactggaaca tctcagcttc tgcagtgaag aaaaattcct   3300

gtgatagttc agttctttag tttttctatt tgaaaaaaaa aaatcattta aatgatcctt   3360

tgttcacggc tctccttaat gactgagtga acagttccta tctgtatatt tgactaaacc   3420

ttttcctaag ctatctctca tggttcctat gtttttttat cataattaaa agcaaaacca   3480

tctggatcac ctaacagtca gaggtcagta tctcagcgtg tgaattatag aggaaataca   3540

gagagaacct cttccacttt tacttttcgt ccaaataaaa tgcatggtgt accagaagtt   3600

gaagatcggg ttgaggattg gggctagctc gatgacacta aggccccaac atcgcgggac   3660

ctgctgtggc gcggattctt aggaacgctg ttctagccgg ccccctctcc aggggtcgcc   3720

gtggccggca ttatttccta gttcttcttg taaccctgag gtgccagcgc ggggagtgag   3780

gaggggtcag ggggctaagg atgcaacctc tgacgttctg cgccttccta ggagagtctt   3840

acatgtgttg agatttcaca agcaatgcga gttgtaaaat accagctcta caagaagcta   3900

ggctctgtga cggcatagtt ttcagtagct ttatcacaat attcacaatg gagaattata   3960

tgacatggta gcagaaatag gcccttttat gtgttgcttc tattttacct caaattgtag   4020

atatagggta atcaataaaa tccatccatg cctttcacac actaagt                 4067


<210>  5111
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  5111

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys 
        595                 600                 605


Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu 
    610                 615                 620


Asn 
625


<210>  5112
<211>  4060
<212>  DNA
<213>  Homo sapiens

<400>  5112
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1980

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   2040

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2100

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2160

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2220

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2280

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2340

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2400

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2460

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2520

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2580

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2640

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2700

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2760

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2820

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2880

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   2940

cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg atcagagtga   3000

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   3060

agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag accccacgtg   3120

gtagacctct tccctcctag gcttaaagta tcagtggttg agaagagctt ttcggacctg   3180

ttactacccc aagctgtagc cttgagttac ggtgtttatt ttccaatcaa gtgaagatat   3240

ctcctacttc tcctactgga acatctcagc ttctgcagtg aagaaaaatt cctgtgatag   3300

ttcagttctt tagtttttct atttgaaaaa aaaaaatcat ttaaatgatc ctttgttcac   3360

ggctctcctt aatgactgag tgaacagttc ctatctgtat atttgactaa accttttcct   3420

aagctatctc tcatggttcc tatgtttttt tatcataatt aaaagcaaaa ccatctggat   3480

cacctaacag tcagaggtca gtatctcagc gtgtgaatta tagaggaaat acagagagaa   3540

cctcttccac ttttactttt cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc   3600

gggttgagga ttggggctag ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt   3660

ggcgcggatt cttaggaacg ctgttctagc cggccccctc tccaggggtc gccgtggccg   3720

gcattatttc ctagttcttc ttgtaaccct gaggtgccag cgcggggagt gaggaggggt   3780

cagggggcta aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg   3840

ttgagatttc acaagcaatg cgagttgtaa aataccagct ctacaagaag ctaggctctg   3900

tgacggcata gttttcagta gctttatcac aatattcaca atggagaatt atatgacatg   3960

gtagcagaaa taggcccttt tatgtgttgc ttctatttta cctcaaattg tagatatagg   4020

gtaatcaata aaatccatcc atgcctttca cacactaagt                         4060


<210>  5113
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  5113

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
                565                 570                 575


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly 
            580                 585                 590


Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600


<210>  5114
<211>  4108
<212>  DNA
<213>  Homo sapiens

<400>  5114
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag    960

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1020

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1080

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1140

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1200

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1260

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1320

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1380

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1440

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1500

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1560

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1620

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1680

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1740

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1800

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1860

tgaaatttgc ttagatttgt tgacagcggt ttcctggagt gctgtcttga gaacgattct   1920

gaggaggctc agcaagaaag agtgtttcag ttgattgggt gtgtctgtca tggagaagga   1980

actcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac   2040

ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg   2100

tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2160

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2220

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2280

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2340

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2400

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2460

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2520

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2580

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2640

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2700

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2760

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2820

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2880

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   2940

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3000

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca   3060

tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg   3120

atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag   3180

actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc   3240

ctaggagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct cctacttctc   3300

ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta   3360

gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg ctctccttaa   3420

tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa gctatctctc   3480

atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca cctaacagtc   3540

agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc tcttccactt   3600

ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg gttgaggatt   3660

ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg cgcggattct   3720

taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc attatttcct   3780

agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca gggggctaag   3840

gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt gagatttcac   3900

aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg acggcatagt   3960

tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt agcagaaata   4020

ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt aatcaataaa   4080

atccatccat gcctttcaca cactaagt                                      4108


<210>  5115
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  5115

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535


<210>  5116
<211>  7041
<212>  DNA
<213>  Homo sapiens

<400>  5116
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag    960

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1020

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1080

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1140

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1200

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1260

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1320

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1380

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1440

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1500

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1560

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1620

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1680

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1740

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1800

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1860

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1920

aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc   1980

ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt   2040

tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa   2100

taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg   2160

ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg   2220

ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga gggagagagt   2280

tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct   2340

tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt   2400

tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc   2460

gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa   2520

ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct   2580

ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg   2640

ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga   2700

aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg   2760

gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc   2820

ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc   2880

tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca   2940

ttaggtaagt gagagtttcc tgcttagtca caggagcgaa tctggagctc atgaggctga   3000

ctcttctaaa atgcagccac aggtagtcat cgaatccggc ttcctatgct gtgcaatcaa   3060

caaatcaaaa taacttgtgt catcattaga atgtcagatg tgcttctacg aactaagctg   3120

actcttttaa ttctttggca aagggttggc aaactaggac tgtttgccaa attcaggctg   3180

cctcctattt ttagagtctt cctgaaacac agctacaccc gtattatcca tggctgcttt   3240

cctgtcacag tgagtaagta gctgggactg agaaggcatg gcctccaaag tctaaaatat   3300

ttactctcta gcactttgta gaaaaacctt agctaggcac agtggctaac gcctgtaatc   3360

ccagcatttt gggaggccaa ggcaggcaga tcacctgagg tcaggagttc cagaccagcc   3420

tggccaacat ggtgaaatcc catctctaca aaaataaaac agttagctgg gcatgatggc   3480

gggtgcctgt aatcccagct actcgggagg ctgaggcagg atagtcgctt gaacccagga   3540

ggtggaggtt gcaatgagcc aagatcatgc cactgcactc cagcctggac gacagagtga   3600

gactccatca caagaaaaaa agaactttgt caacctctgt cttagggcgc cttgtcacag   3660

gcttcgggtc agacggattc aaccttgcat cagccatttg ttagccaggt cactctgttc   3720

tttgtctgta aatgagattg atcgttgttc ccactgagag tgtcagctcc ttcccgtaga   3780

gcaggcatga tgattgtact cacctctgac accattgtga gtgccacatt ccttcccacg   3840

tccttgtcac tgtaagagat gcccacctga gcaccaaccc caggttatct tcccctttgt   3900

cttccagccc cccagaaaca gctacgactc aacctaccca atcatttcat catcagattg   3960

ccactgtctc tagttcaggt ctcttgggac tggcactcag aaatctcata ataaatcctc   4020

ttgaggcttc tcatacactc gtcttcttcc aatcttcttt ccctcaaaat ctcatatttt   4080

ggttccactt cacccaccgt cattctccat atcactccca ggagttaggc aaaaagcccc   4140

ttccgttctt ccgtatgtta aacttagaat cactctgttc cctgctctgc gtttctattt   4200

tttgtttttc ctccatttac tagtagctta acactttcta acagtgttct tattattgat   4260

acgtatctat ctcttccata agcttataag gtcacggata atacttctca ttgtagtacg   4320

taaatgacgt gggctagata tgagttgaat aaacagttat acctgtaaat tcttacagag   4380

tgaaaataaa ttgttatact ttacaatttg tttctctctt tagaccattt ccaggacttg   4440

tgattaataa ccgtgagtat tttgtgaagt gttttgtttt tgttttttcc tggggtctga   4500

cgtgtgtgcg tgtgagtgtg tatacatgct taacgtatat cacgttactt cacctatgtc   4560

agtaaccagg ccaaatactt gttttagccc tcagtaaaaa caccaggcac ttcctagttg   4620

taaaattatt caagcttctt aacttcctat cctcgatgca cttaatcata aaatggtaat   4680

aatagcaccg attttggggg agtcgttcca gtagatggaa agcatctgga acaggtgtca   4740

gcaagctcct gccgacgtgt atgcataaag ttttattgaa accaccatcg tgtccatttg   4800

tttatggcag aactgagaga tggcagcagc aagtgtgtgc ctgcaaaacc taaaatattt   4860

actaattggc tctgcaagaa aagagtttgc atccccctaa cctagaacag tgtctagcct   4920

ctagtatgtg tttagcctac agtatgtgct cagcgaatac aatctatatt tattactgct   4980

tttatgactg ttataattac tgtgcttgga tttcgttaca aagtaagtca caatgtgcct   5040

gcttctgtta gtatttcagc acagtgcctg gcacacatgg ggctctcaaa tattgctgag   5100

cgagtgaaca aatgtccttt caattcctta acgttgatgt cattttcaat agtattttga   5160

gccaaactta attttgcgag tgtgttttgt tttcttaact ttattattaa aaatgtataa   5220

aagtgaggcc aggcgtggtg gctcacgcct gtaatcccag cagtttggga ggctgaggca   5280

ggcggatcag ttgaggttgg gagttggaga ccagcccgtc caacatggtg aaagcctgtc   5340

tctactaaaa atacaaaaat cagctgggtg tggtggcgcg tgcctgtaat cccagctact   5400

caggaggctg aggcaggaga gttgcttgaa tcctagaggt ggaggttgca gtgagctgag   5460

atcgtgccat tgcactccag cctgggcaac aagagcaaaa ctctgtccca ataaataaat   5520

aaataaaatg ttctcttttg ttcctgttct tgtgcggtag tgtggtatag agttttatgg   5580

taattactgt gaattagtga ttctgaggga catatcagaa ctctgaggtt tgtttccttc   5640

tcatcttgag ggaaacagca aatgtatgtt aaaatgcttt tccaagggaa caacacatcc   5700

ttacattatt taaaccaatc tgcttcattt tcagagctgg ttgatcagag tgagtcagaa   5760

ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc cacagaagaa   5820

ataaaagaga ctgatggaag ctctcagatc aagcaagaac cagaccccac gtggtagacc   5880

tcttccctcc taggcttaaa gtatcagtgg ttgagaagag cttttcggac ctgttactac   5940

cccaagctgt gtaatatact tgtataacag aaataccttc tatacaaacc tttttttcta   6000

cttttagata gaaatgtcta ctttttcagc agttctgtga attaaagagc agagtgactg   6060

tgggtctgga atggctggtg tacttgggaa tgtactatca ggattttaca gcaatgctgg   6120

gaaatgacag ggaaaatgac aggaatgaat ctcaccagat tttttatgta ctcagcagag   6180

ccttgagtta cggtgtttat tttccaatca agtgaagata tctcctactt ctcctactgg   6240

aacatctcag cttctgcagt gaagaaaaat tcctgtgata gttcagttct ttagtttttc   6300

tatttgaaaa aaaaaaatca tttaaatgat cctttgttca cggctctcct taatgactga   6360

gtgaacagtt cctatctgta tatttgacta aaccttttcc taagctatct ctcatggttc   6420

ctatgttttt ttatcataat taaaagcaaa accatctgga tcacctaaca gtcagaggtc   6480

agtatctcag cgtgtgaatt atagaggaaa tacagagaga acctcttcca cttttacttt   6540

tcgtccaaat aaaatgcatg gtgtaccaga agttgaagat cgggttgagg attggggcta   6600

gctcgatgac actaaggccc caacatcgcg ggacctgctg tggcgcggat tcttaggaac   6660

gctgttctag ccggccccct ctccaggggt cgccgtggcc ggcattattt cctagttctt   6720

cttgtaaccc tgaggtgcca gcgcggggag tgaggagggg tcagggggct aaggatgcaa   6780

cctctgacgt tctgcgcctt cctaggagag tcttacatgt gttgagattt cacaagcaat   6840

gcgagttgta aaataccagc tctacaagaa gctaggctct gtgacggcat agttttcagt   6900

agctttatca caatattcac aatggagaat tatatgacat ggtagcagaa ataggccctt   6960

ttatgtgttg cttctatttt acctcaaatt gtagatatag ggtaatcaat aaaatccatc   7020

catgcctttc acacactaag t                                             7041


<210>  5117
<211>  896
<212>  PRT
<213>  Homo sapiens

<400>  5117

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr 
                565                 570                 575


Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys 
            580                 585                 590


Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro 
        595                 600                 605


Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys 
    610                 615                 620


Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val 
625                 630                 635                 640


Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg 
                645                 650                 655


Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly 
            660                 665                 670


Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys 
        675                 680                 685


Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly 
    690                 695                 700


Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro 
705                 710                 715                 720


Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg 
                725                 730                 735


Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys 
            740                 745                 750


Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala 
        755                 760                 765


Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser 
    770                 775                 780


Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile 
785                 790                 795                 800


Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val 
                805                 810                 815


Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg 
            820                 825                 830


Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr 
        835                 840                 845


Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro 
    850                 855                 860


Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met 
865                 870                 875                 880


Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
                885                 890                 895


<210>  5118
<211>  4058
<212>  DNA
<213>  Homo sapiens

<400>  5118
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1080

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1140

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1200

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1260

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1320

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1380

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1440

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1500

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1560

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1620

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1680

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1740

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1800

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1860

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   1920

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   1980

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2040

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2100

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2160

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2220

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2280

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2340

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2400

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2460

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2520

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2580

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2640

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2700

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2760

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2820

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   2880

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   2940

cggtcattag accatttcca ggacttgtga ttaataacca gctggttgat cagagtgagt   3000

cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt ccagccacag   3060

aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac cccacgtggt   3120

agacctcttc cctcctaggc ttaaagtatc agtggttgag aagagctttt cggacctgtt   3180

actaccccaa gctgtagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct   3240

cctacttctc ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt   3300

cagttcttta gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg   3360

ctctccttaa tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa   3420

gctatctctc atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca   3480

cctaacagtc agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc   3540

tcttccactt ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg   3600

gttgaggatt ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg   3660

cgcggattct taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc   3720

attatttcct agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca   3780

gggggctaag gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt   3840

gagatttcac aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg   3900

acggcatagt tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt   3960

agcagaaata ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt   4020

aatcaataaa atccatccat gcctttcaca cactaagt                           4058


<210>  5119
<211>  954
<212>  PRT
<213>  Homo sapiens

<400>  5119

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly 
    530                 535                 540


Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro 
545                 550                 555                 560


Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser 
                565                 570                 575


Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser 
            580                 585                 590


Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr 
        595                 600                 605


Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser 
    610                 615                 620


Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile 
625                 630                 635                 640


Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala 
                645                 650                 655


Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro 
            660                 665                 670


Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp 
        675                 680                 685


Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala 
    690                 695                 700


Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser 
705                 710                 715                 720


Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe 
                725                 730                 735


Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg 
            740                 745                 750


Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu 
        755                 760                 765


Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile 
    770                 775                 780


Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu 
785                 790                 795                 800


Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser 
                805                 810                 815


Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe 
            820                 825                 830


Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val 
        835                 840                 845


Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly 
    850                 855                 860


Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser 
865                 870                 875                 880


Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val 
                885                 890                 895


Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln 
            900                 905                 910


Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln 
        915                 920                 925


Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser 
    930                 935                 940


Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  5120
<211>  7741
<212>  DNA
<213>  Homo sapiens

<400>  5120
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1980

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   2040

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2100

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2160

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2220

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2280

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2340

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2400

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2460

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2520

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2580

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2640

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2700

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2760

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2820

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2880

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   2940

cacggtcatt aggtaagtga gagtttcctg cttagtcaca ggagcgaatc tggagctcat   3000

gaggctgact cttctaaaat gcagccacag gtagtcatcg aatccggctt cctatgctgt   3060

gcaatcaaca aatcaaaata acttgtgtca tcattagaat gtcagatgtg cttctacgaa   3120

ctaagctgac tcttttaatt ctttggcaaa gggttggcaa actaggactg tttgccaaat   3180

tcaggctgcc tcctattttt agagtcttcc tgaaacacag ctacacccgt attatccatg   3240

gctgctttcc tgtcacagtg agtaagtagc tgggactgag aaggcatggc ctccaaagtc   3300

taaaatattt actctctagc actttgtaga aaaaccttag ctaggcacag tggctaacgc   3360

ctgtaatccc agcattttgg gaggccaagg caggcagatc acctgaggtc aggagttcca   3420

gaccagcctg gccaacatgg tgaaatccca tctctacaaa aataaaacag ttagctgggc   3480

atgatggcgg gtgcctgtaa tcccagctac tcgggaggct gaggcaggat agtcgcttga   3540

acccaggagg tggaggttgc aatgagccaa gatcatgcca ctgcactcca gcctggacga   3600

cagagtgaga ctccatcaca agaaaaaaag aactttgtca acctctgtct tagggcgcct   3660

tgtcacaggc ttcgggtcag acggattcaa ccttgcatca gccatttgtt agccaggtca   3720

ctctgttctt tgtctgtaaa tgagattgat cgttgttccc actgagagtg tcagctcctt   3780

cccgtagagc aggcatgatg attgtactca cctctgacac cattgtgagt gccacattcc   3840

ttcccacgtc cttgtcactg taagagatgc ccacctgagc accaacccca ggttatcttc   3900

ccctttgtct tccagccccc cagaaacagc tacgactcaa cctacccaat catttcatca   3960

tcagattgcc actgtctcta gttcaggtct cttgggactg gcactcagaa atctcataat   4020

aaatcctctt gaggcttctc atacactcgt cttcttccaa tcttctttcc ctcaaaatct   4080

catattttgg ttccacttca cccaccgtca ttctccatat cactcccagg agttaggcaa   4140

aaagcccctt ccgttcttcc gtatgttaaa cttagaatca ctctgttccc tgctctgcgt   4200

ttctattttt tgtttttcct ccatttacta gtagcttaac actttctaac agtgttctta   4260

ttattgatac gtatctatct cttccataag cttataaggt cacggataat acttctcatt   4320

gtagtacgta aatgacgtgg gctagatatg agttgaataa acagttatac ctgtaaattc   4380

ttacagagtg aaaataaatt gttatacttt acaatttgtt tctctcttta gaccatttcc   4440

aggacttgtg attaataacc gtgagtattt tgtgaagtgt tttgtttttg ttttttcctg   4500

gggtctgacg tgtgtgcgtg tgagtgtgta tacatgctta acgtatatca cgttacttca   4560

cctatgtcag taaccaggcc aaatacttgt tttagccctc agtaaaaaca ccaggcactt   4620

cctagttgta aaattattca agcttcttaa cttcctatcc tcgatgcact taatcataaa   4680

atggtaataa tagcaccgat tttgggggag tcgttccagt agatggaaag catctggaac   4740

aggtgtcagc aagctcctgc cgacgtgtat gcataaagtt ttattgaaac caccatcgtg   4800

tccatttgtt tatggcagaa ctgagagatg gcagcagcaa gtgtgtgcct gcaaaaccta   4860

aaatatttac taattggctc tgcaagaaaa gagtttgcat ccccctaacc tagaacagtg   4920

tctagcctct agtatgtgtt tagcctacag tatgtgctca gcgaatacaa tctatattta   4980

ttactgcttt tatgactgtt ataattactg tgcttggatt tcgttacaaa gtaagtcaca   5040

atgtgcctgc ttctgttagt atttcagcac agtgcctggc acacatgggg ctctcaaata   5100

ttgctgagcg agtgaacaaa tgtcctttca attccttaac gttgatgtca ttttcaatag   5160

tattttgagc caaacttaat tttgcgagtg tgttttgttt tcttaacttt attattaaaa   5220

atgtataaaa gtgaggccag gcgtggtggc tcacgcctgt aatcccagca gtttgggagg   5280

ctgaggcagg cggatcagtt gaggttggga gttggagacc agcccgtcca acatggtgaa   5340

agcctgtctc tactaaaaat acaaaaatca gctgggtgtg gtggcgcgtg cctgtaatcc   5400

cagctactca ggaggctgag gcaggagagt tgcttgaatc ctagaggtgg aggttgcagt   5460

gagctgagat cgtgccattg cactccagcc tgggcaacaa gagcaaaact ctgtcccaat   5520

aaataaataa ataaaatgtt ctcttttgtt cctgttcttg tgcggtagtg tggtatagag   5580

ttttatggta attactgtga attagtgatt ctgagggaca tatcagaact ctgaggtttg   5640

tttccttctc atcttgaggg aaacagcaaa tgtatgttaa aatgcttttc caagggaaca   5700

acacatcctt acattattta aaccaatctg cttcattttc agagctggtt gatcagagtg   5760

agtcagaagg ccccgtgata caagaatcag ctgaaccaag ccagttggaa gttccagcca   5820

cagaagaaat aaaagagact gatggaagct ctcagatcaa gcaagaacca gaccccacgt   5880

ggtagacctc ttccctccta gggtaaatca gcttctgtgt cagggatgct gtgtggtgtc   5940

catctgaacc ccctgcatac gcgtagctaa tgtgatctcc ccactttcac ataagatggt   6000

ggccctgcct tcagggaatg tgggagccag gtgggagcct tcccggatat ttaagctaga   6060

agattctaca gggagattct ccttggatca atatatgtct ctcagtcaaa gatgtaaaag   6120

cacttttgcc ttaaaaagaa tgttctgttt ctaaatagag tcaacgttgt cctcctcatt   6180

ggaattcact atgagtcaga atcattagac tgactttttt ttttccatag taatagtatt   6240

ttgcagagtc tcacagagct gcagatcttt tgttcatctt gcagagttaa caagtctgat   6300

cctgttagtc cagatttctt aaatttggcc aagttataat aggagcagta gcttgagacc   6360

cgaagtcagg aaactttgac aatggatttt tttttttaat ccagagactt gtactggaat   6420

ttgccttacc ctgtcagctc atggacttaa ggtttcatcc cgctttatga gtgcttctga   6480

atccaagtca ttgttacctg aatttgcaaa ttaagttgtg atattcgtga ctgttaaatt   6540

cctgtaatta gattaacctc tttgcttgct tgtttgtttt ctctcctatt ttagcttaaa   6600

gtatcagtgg ttgagaagag cttttcggac ctgttactac cccaagctgt gtaatatact   6660

tgtataacag aaataccttc tatacaaacc tttttttcta cttttagata gaaatgtcta   6720

ctttttcagc agttctgtga attaaagagc agagtgactg tgggtctgga atggctggtg   6780

tacttgggaa tgtactatca ggattttaca gcaatgctgg gaaatgacag ggaaaatgac   6840

aggaatgaat ctcaccagat tttttatgta ctcagcagag ccttgagtta cggtgtttat   6900

tttccaatca agtgaagata tctcctactt ctcctactgg aacatctcag cttctgcagt   6960

gaagaaaaat tcctgtgata gttcagttct ttagtttttc tatttgaaaa aaaaaaatca   7020

tttaaatgat cctttgttca cggctctcct taatgactga gtgaacagtt cctatctgta   7080

tatttgacta aaccttttcc taagctatct ctcatggttc ctatgttttt ttatcataat   7140

taaaagcaaa accatctgga tcacctaaca gtcagaggtc agtatctcag cgtgtgaatt   7200

atagaggaaa tacagagaga acctcttcca cttttacttt tcgtccaaat aaaatgcatg   7260

gtgtaccaga agttgaagat cgggttgagg attggggcta gctcgatgac actaaggccc   7320

caacatcgcg ggacctgctg tggcgcggat tcttaggaac gctgttctag ccggccccct   7380

ctccaggggt cgccgtggcc ggcattattt cctagttctt cttgtaaccc tgaggtgcca   7440

gcgcggggag tgaggagggg tcagggggct aaggatgcaa cctctgacgt tctgcgcctt   7500

cctaggagag tcttacatgt gttgagattt cacaagcaat gcgagttgta aaataccagc   7560

tctacaagaa gctaggctct gtgacggcat agttttcagt agctttatca caatattcac   7620

aatggagaat tatatgacat ggtagcagaa ataggccctt ttatgtgttg cttctatttt   7680

acctcaaatt gtagatatag ggtaatcaat aaaatccatc catgcctttc acacactaag   7740

t                                                                   7741


<210>  5121
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  5121

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
                565                 570                 575


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly 
            580                 585                 590


Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600


<210>  5122
<211>  5099
<212>  DNA
<213>  Homo sapiens

<400>  5122
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1080

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1140

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1200

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1260

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1320

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1380

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1440

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1500

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1560

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1620

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1680

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1740

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1800

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1860

aagagatttt taatttgaaa tttgcttaga tttgttgaca gcggtttcct ggagtgctgt   1920

cttgagaacg attctgagga ggctcagcaa gaaagagtgt ttcagttgat tgggtgtgtc   1980

tgtcatggag aaggaactca agctcttgga ctcaccgagg cagtaaaagt accatatcct   2040

gtgtttgaat caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc   2100

cgaagcccta cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa   2160

atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct   2220

agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat   2280

tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc   2340

tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg   2400

agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa   2460

aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg   2520

ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg   2580

ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa   2640

gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc   2700

acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca   2760

tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga   2820

ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg   2880

aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca   2940

attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt caaagccccc   3000

agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc   3060

acggtcatta gaccatttcc aggacttgtg attaataacc agctggttga tcagagtgag   3120

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   3180

gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga ccccacgtgg   3240

tagacctctt ccctcctagg gtaaatcagc ttctgtgtca gggatgctgt gtggtgtcca   3300

tctgaacccc ctgcatacgc gtagctaatg tgatctcccc actttcacat aagatggtgg   3360

ccctgccttc agggaatgtg ggagccaggt gggagccttc ccggatattt aagctagaag   3420

attctacagg gagattctcc ttggatcaat atatgtctct cagtcaaaga tgtaaaagca   3480

cttttgcctt aaaaagaatg ttctgtttct aaatagagtc aacgttgtcc tcctcattgg   3540

aattcactat gagtcagaat cattagactg actttttttt ttccatagta atagtatttt   3600

gcagagtctc acagagctgc agatcttttg ttcatcttgc agagttaaca agtctgatcc   3660

tgttagtcca gatttcttaa atttggccaa gttataatag gagcagtagc ttgagacccg   3720

aagtcaggaa actttgacaa tggatttttt tttttaatcc agagacttgt actggaattt   3780

gccttaccct gtcagctcat ggacttaagg tttcatcccg ctttatgagt gcttctgaat   3840

ccaagtcatt gttacctgaa tttgcaaatt aagttgtgat attcgtgact gttaaattcc   3900

tgtaattaga ttaacctctt tgcttgcttg tttgttttct ctcctatttt agcttaaagt   3960

atcagtggtt gagaagagct tttcggacct gttactaccc caagctgtgt aatatacttg   4020

tataacagaa ataccttcta tacaaacctt tttttctact tttagataga aatgtctact   4080

ttttcagcag ttctgtgaat taaagagcag agtgactgtg ggtctggaat ggctggtgta   4140

cttgggaatg tactatcagg attttacagc aatgctggga aatgacaggg aaaatgacag   4200

gaatgaatct caccagattt tttatgtact cagcagagcc ttgagttacg gtgtttattt   4260

tccaatcaag tgaagatatc tcctacttct cctactggaa catctcagct tctgcagtga   4320

agaaaaattc ctgtgatagt tcagttcttt agtttttcta tttgaaaaaa aaaaatcatt   4380

taaatgatcc tttgttcacg gctctcctta atgactgagt gaacagttcc tatctgtata   4440

tttgactaaa ccttttccta agctatctct catggttcct atgttttttt atcataatta   4500

aaagcaaaac catctggatc acctaacagt cagaggtcag tatctcagcg tgtgaattat   4560

agaggaaata cagagagaac ctcttccact tttacttttc gtccaaataa aatgcatggt   4620

gtaccagaag ttgaagatcg ggttgaggat tggggctagc tcgatgacac taaggcccca   4680

acatcgcggg acctgctgtg gcgcggattc ttaggaacgc tgttctagcc ggccccctct   4740

ccaggggtcg ccgtggccgg cattatttcc tagttcttct tgtaaccctg aggtgccagc   4800

gcggggagtg aggaggggtc agggggctaa ggatgcaacc tctgacgttc tgcgccttcc   4860

taggagagtc ttacatgtgt tgagatttca caagcaatgc gagttgtaaa ataccagctc   4920

tacaagaagc taggctctgt gacggcatag ttttcagtag ctttatcaca atattcacaa   4980

tggagaatta tatgacatgg tagcagaaat aggccctttt atgtgttgct tctattttac   5040

ctcaaattgt agatataggg taatcaataa aatccatcca tgcctttcac acactaagt    5099


<210>  5123
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  5123

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  5124
<211>  7681
<212>  DNA
<213>  Homo sapiens

<400>  5124
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1080

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1140

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1200

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1260

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1320

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1380

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1440

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1500

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1560

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1620

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1680

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1740

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1800

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1860

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1920

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   1980

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2040

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2100

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2160

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2220

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2280

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2340

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2400

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2460

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2520

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2580

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2640

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2700

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2760

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2820

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   2880

cacggtcatt aggtaagtga gagtttcctg cttagtcaca ggagcgaatc tggagctcat   2940

gaggctgact cttctaaaat gcagccacag gtagtcatcg aatccggctt cctatgctgt   3000

gcaatcaaca aatcaaaata acttgtgtca tcattagaat gtcagatgtg cttctacgaa   3060

ctaagctgac tcttttaatt ctttggcaaa gggttggcaa actaggactg tttgccaaat   3120

tcaggctgcc tcctattttt agagtcttcc tgaaacacag ctacacccgt attatccatg   3180

gctgctttcc tgtcacagtg agtaagtagc tgggactgag aaggcatggc ctccaaagtc   3240

taaaatattt actctctagc actttgtaga aaaaccttag ctaggcacag tggctaacgc   3300

ctgtaatccc agcattttgg gaggccaagg caggcagatc acctgaggtc aggagttcca   3360

gaccagcctg gccaacatgg tgaaatccca tctctacaaa aataaaacag ttagctgggc   3420

atgatggcgg gtgcctgtaa tcccagctac tcgggaggct gaggcaggat agtcgcttga   3480

acccaggagg tggaggttgc aatgagccaa gatcatgcca ctgcactcca gcctggacga   3540

cagagtgaga ctccatcaca agaaaaaaag aactttgtca acctctgtct tagggcgcct   3600

tgtcacaggc ttcgggtcag acggattcaa ccttgcatca gccatttgtt agccaggtca   3660

ctctgttctt tgtctgtaaa tgagattgat cgttgttccc actgagagtg tcagctcctt   3720

cccgtagagc aggcatgatg attgtactca cctctgacac cattgtgagt gccacattcc   3780

ttcccacgtc cttgtcactg taagagatgc ccacctgagc accaacccca ggttatcttc   3840

ccctttgtct tccagccccc cagaaacagc tacgactcaa cctacccaat catttcatca   3900

tcagattgcc actgtctcta gttcaggtct cttgggactg gcactcagaa atctcataat   3960

aaatcctctt gaggcttctc atacactcgt cttcttccaa tcttctttcc ctcaaaatct   4020

catattttgg ttccacttca cccaccgtca ttctccatat cactcccagg agttaggcaa   4080

aaagcccctt ccgttcttcc gtatgttaaa cttagaatca ctctgttccc tgctctgcgt   4140

ttctattttt tgtttttcct ccatttacta gtagcttaac actttctaac agtgttctta   4200

ttattgatac gtatctatct cttccataag cttataaggt cacggataat acttctcatt   4260

gtagtacgta aatgacgtgg gctagatatg agttgaataa acagttatac ctgtaaattc   4320

ttacagagtg aaaataaatt gttatacttt acaatttgtt tctctcttta gaccatttcc   4380

aggacttgtg attaataacc gtgagtattt tgtgaagtgt tttgtttttg ttttttcctg   4440

gggtctgacg tgtgtgcgtg tgagtgtgta tacatgctta acgtatatca cgttacttca   4500

cctatgtcag taaccaggcc aaatacttgt tttagccctc agtaaaaaca ccaggcactt   4560

cctagttgta aaattattca agcttcttaa cttcctatcc tcgatgcact taatcataaa   4620

atggtaataa tagcaccgat tttgggggag tcgttccagt agatggaaag catctggaac   4680

aggtgtcagc aagctcctgc cgacgtgtat gcataaagtt ttattgaaac caccatcgtg   4740

tccatttgtt tatggcagaa ctgagagatg gcagcagcaa gtgtgtgcct gcaaaaccta   4800

aaatatttac taattggctc tgcaagaaaa gagtttgcat ccccctaacc tagaacagtg   4860

tctagcctct agtatgtgtt tagcctacag tatgtgctca gcgaatacaa tctatattta   4920

ttactgcttt tatgactgtt ataattactg tgcttggatt tcgttacaaa gtaagtcaca   4980

atgtgcctgc ttctgttagt atttcagcac agtgcctggc acacatgggg ctctcaaata   5040

ttgctgagcg agtgaacaaa tgtcctttca attccttaac gttgatgtca ttttcaatag   5100

tattttgagc caaacttaat tttgcgagtg tgttttgttt tcttaacttt attattaaaa   5160

atgtataaaa gtgaggccag gcgtggtggc tcacgcctgt aatcccagca gtttgggagg   5220

ctgaggcagg cggatcagtt gaggttggga gttggagacc agcccgtcca acatggtgaa   5280

agcctgtctc tactaaaaat acaaaaatca gctgggtgtg gtggcgcgtg cctgtaatcc   5340

cagctactca ggaggctgag gcaggagagt tgcttgaatc ctagaggtgg aggttgcagt   5400

gagctgagat cgtgccattg cactccagcc tgggcaacaa gagcaaaact ctgtcccaat   5460

aaataaataa ataaaatgtt ctcttttgtt cctgttcttg tgcggtagtg tggtatagag   5520

ttttatggta attactgtga attagtgatt ctgagggaca tatcagaact ctgaggtttg   5580

tttccttctc atcttgaggg aaacagcaaa tgtatgttaa aatgcttttc caagggaaca   5640

acacatcctt acattattta aaccaatctg cttcattttc agagctggtt gatcagagtg   5700

agtcagaagg ccccgtgata caagaatcag ctgaaccaag ccagttggaa gttccagcca   5760

cagaagaaat aaaagagact gatggaagct ctcagatcaa gcaagaacca gaccccacgt   5820

ggtagacctc ttccctccta gggtaaatca gcttctgtgt cagggatgct gtgtggtgtc   5880

catctgaacc ccctgcatac gcgtagctaa tgtgatctcc ccactttcac ataagatggt   5940

ggccctgcct tcagggaatg tgggagccag gtgggagcct tcccggatat ttaagctaga   6000

agattctaca gggagattct ccttggatca atatatgtct ctcagtcaaa gatgtaaaag   6060

cacttttgcc ttaaaaagaa tgttctgttt ctaaatagag tcaacgttgt cctcctcatt   6120

ggaattcact atgagtcaga atcattagac tgactttttt ttttccatag taatagtatt   6180

ttgcagagtc tcacagagct gcagatcttt tgttcatctt gcagagttaa caagtctgat   6240

cctgttagtc cagatttctt aaatttggcc aagttataat aggagcagta gcttgagacc   6300

cgaagtcagg aaactttgac aatggatttt tttttttaat ccagagactt gtactggaat   6360

ttgccttacc ctgtcagctc atggacttaa ggtttcatcc cgctttatga gtgcttctga   6420

atccaagtca ttgttacctg aatttgcaaa ttaagttgtg atattcgtga ctgttaaatt   6480

cctgtaatta gattaacctc tttgcttgct tgtttgtttt ctctcctatt ttagcttaaa   6540

gtatcagtgg ttgagaagag cttttcggac ctgttactac cccaagctgt gtaatatact   6600

tgtataacag aaataccttc tatacaaacc tttttttcta cttttagata gaaatgtcta   6660

ctttttcagc agttctgtga attaaagagc agagtgactg tgggtctgga atggctggtg   6720

tacttgggaa tgtactatca ggattttaca gcaatgctgg gaaatgacag ggaaaatgac   6780

aggaatgaat ctcaccagat tttttatgta ctcagcagag ccttgagtta cggtgtttat   6840

tttccaatca agtgaagata tctcctactt ctcctactgg aacatctcag cttctgcagt   6900

gaagaaaaat tcctgtgata gttcagttct ttagtttttc tatttgaaaa aaaaaaatca   6960

tttaaatgat cctttgttca cggctctcct taatgactga gtgaacagtt cctatctgta   7020

tatttgacta aaccttttcc taagctatct ctcatggttc ctatgttttt ttatcataat   7080

taaaagcaaa accatctgga tcacctaaca gtcagaggtc agtatctcag cgtgtgaatt   7140

atagaggaaa tacagagaga acctcttcca cttttacttt tcgtccaaat aaaatgcatg   7200

gtgtaccaga agttgaagat cgggttgagg attggggcta gctcgatgac actaaggccc   7260

caacatcgcg ggacctgctg tggcgcggat tcttaggaac gctgttctag ccggccccct   7320

ctccaggggt cgccgtggcc ggcattattt cctagttctt cttgtaaccc tgaggtgcca   7380

gcgcggggag tgaggagggg tcagggggct aaggatgcaa cctctgacgt tctgcgcctt   7440

cctaggagag tcttacatgt gttgagattt cacaagcaat gcgagttgta aaataccagc   7500

tctacaagaa gctaggctct gtgacggcat agttttcagt agctttatca caatattcac   7560

aatggagaat tatatgacat ggtagcagaa ataggccctt ttatgtgttg cttctatttt   7620

acctcaaatt gtagatatag ggtaatcaat aaaatccatc catgcctttc acacactaag   7680

t                                                                   7681


<210>  5125
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  5125

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
                565                 570                 575


Ser Ser Leu Leu Lys Asn Leu Asn 
            580


<210>  5126
<211>  4179
<212>  DNA
<213>  Homo sapiens

<400>  5126
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1080

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1140

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1200

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1260

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1320

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1380

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1440

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1500

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1560

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1620

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1680

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1740

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1800

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1860

aagagatttt taatttgaaa tttgcttaga tttgttgaca gcggtttcct ggagtgctgt   1920

cttgagaacg attctgagga ggctcagcaa gaaagagtgt ttcagttgat tgggtgtgtc   1980

tgtcatggag aaggaactca agctcttgga ctcaccgagg cagtaaaagt accatatcct   2040

gtgtttgaat caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc   2100

cgaagcccta cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa   2160

atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct   2220

agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat   2280

tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc   2340

tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg   2400

agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa   2460

aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg   2520

ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg   2580

ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa   2640

gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc   2700

acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca   2760

tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga   2820

ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg   2880

aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca   2940

attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt caaagccccc   3000

agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc   3060

acggtcatta gaccatttcc aggacttgtg attaataacc agctggttga tcagagtgag   3120

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   3180

gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga ccccacgtgg   3240

tagacctctt ccctcctagg cttaaagtat cagtggttga gaagagcttt tcggacctgt   3300

tactacccca agctgtagcc ttgagttacg gtgtttattt tccaatcaag tgaagatatc   3360

tcctacttct cctactggaa catctcagct tctgcagtga agaaaaattc ctgtgatagt   3420

tcagttcttt agtttttcta tttgaaaaaa aaaaatcatt taaatgatcc tttgttcacg   3480

gctctcctta atgactgagt gaacagttcc tatctgtata tttgactaaa ccttttccta   3540

agctatctct catggttcct atgttttttt atcataatta aaagcaaaac catctggatc   3600

acctaacagt cagaggtcag tatctcagcg tgtgaattat agaggaaata cagagagaac   3660

ctcttccact tttacttttc gtccaaataa aatgcatggt gtaccagaag ttgaagatcg   3720

ggttgaggat tggggctagc tcgatgacac taaggcccca acatcgcggg acctgctgtg   3780

gcgcggattc ttaggaacgc tgttctagcc ggccccctct ccaggggtcg ccgtggccgg   3840

cattatttcc tagttcttct tgtaaccctg aggtgccagc gcggggagtg aggaggggtc   3900

agggggctaa ggatgcaacc tctgacgttc tgcgccttcc taggagagtc ttacatgtgt   3960

tgagatttca caagcaatgc gagttgtaaa ataccagctc tacaagaagc taggctctgt   4020

gacggcatag ttttcagtag ctttatcaca atattcacaa tggagaatta tatgacatgg   4080

tagcagaaat aggccctttt atgtgttgct tctattttac ctcaaattgt agatataggg   4140

taatcaataa aatccatcca tgcctttcac acactaagt                          4179


<210>  5127
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  5127

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  5128
<211>  4074
<212>  DNA
<213>  Homo sapiens

<400>  5128
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1080

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1140

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1200

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1260

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1320

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1380

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1440

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1500

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1560

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1620

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1680

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1740

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1800

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1860

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1920

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   1980

taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2040

ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2100

ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2160

ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2220

ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2280

atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2340

agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2400

agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2460

tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2520

ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2580

tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2640

ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2700

atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2760

ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2820

tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   2880

ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   2940

tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3000

ttatcaaatt cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg   3060

atcagagtga gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag   3120

ttccagccac agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag   3180

accccacgtg gtagacctct tccctcctag gagccttgag ttacggtgtt tattttccaa   3240

tcaagtgaag atatctccta cttctcctac tggaacatct cagcttctgc agtgaagaaa   3300

aattcctgtg atagttcagt tctttagttt ttctatttga aaaaaaaaaa tcatttaaat   3360

gatcctttgt tcacggctct ccttaatgac tgagtgaaca gttcctatct gtatatttga   3420

ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt tttttatcat aattaaaagc   3480

aaaaccatct ggatcaccta acagtcagag gtcagtatct cagcgtgtga attatagagg   3540

aaatacagag agaacctctt ccacttttac ttttcgtcca aataaaatgc atggtgtacc   3600

agaagttgaa gatcgggttg aggattgggg ctagctcgat gacactaagg ccccaacatc   3660

gcgggacctg ctgtggcgcg gattcttagg aacgctgttc tagccggccc cctctccagg   3720

ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa ccctgaggtg ccagcgcggg   3780

gagtgaggag gggtcagggg gctaaggatg caacctctga cgttctgcgc cttcctagga   3840

gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc agctctacaa   3900

gaagctaggc tctgtgacgg catagttttc agtagcttta tcacaatatt cacaatggag   3960

aattatatga catggtagca gaaataggcc cttttatgtg ttgcttctat tttacctcaa   4020

attgtagata tagggtaatc aataaaatcc atccatgcct ttcacacact aagt         4074


<210>  5129
<211>  978
<212>  PRT
<213>  Homo sapiens

<400>  5129

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu 
            580                 585                 590


Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg 
        595                 600                 605


Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys 
    610                 615                 620


Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys 
625                 630                 635                 640


Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly 
                645                 650                 655


Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn 
            660                 665                 670


Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn 
        675                 680                 685


Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu 
    690                 695                 700


Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu 
705                 710                 715                 720


Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys 
                725                 730                 735


Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu 
            740                 745                 750


Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile 
        755                 760                 765


Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile 
    770                 775                 780


Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser 
785                 790                 795                 800


Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr 
                805                 810                 815


Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro 
            820                 825                 830


Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu 
        835                 840                 845


Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile 
    850                 855                 860


Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn 
865                 870                 875                 880


Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys 
                885                 890                 895


Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser 
            900                 905                 910


Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val 
        915                 920                 925


Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile 
    930                 935                 940


Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu 
945                 950                 955                 960


Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro 
                965                 970                 975


Thr Trp 



<210>  5130
<211>  6989
<212>  DNA
<213>  Homo sapiens

<400>  5130
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1080

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1140

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1200

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1260

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1320

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1380

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1440

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1500

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1560

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1620

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1680

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1740

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1800

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1860

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1920

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   1980

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2040

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2100

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2160

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2220

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2280

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2340

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2400

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2460

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2520

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2580

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2640

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2700

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2760

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2820

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   2880

cacggtcatt aggtaagtga gagtttcctg cttagtcaca ggagcgaatc tggagctcat   2940

gaggctgact cttctaaaat gcagccacag gtagtcatcg aatccggctt cctatgctgt   3000

gcaatcaaca aatcaaaata acttgtgtca tcattagaat gtcagatgtg cttctacgaa   3060

ctaagctgac tcttttaatt ctttggcaaa gggttggcaa actaggactg tttgccaaat   3120

tcaggctgcc tcctattttt agagtcttcc tgaaacacag ctacacccgt attatccatg   3180

gctgctttcc tgtcacagtg agtaagtagc tgggactgag aaggcatggc ctccaaagtc   3240

taaaatattt actctctagc actttgtaga aaaaccttag ctaggcacag tggctaacgc   3300

ctgtaatccc agcattttgg gaggccaagg caggcagatc acctgaggtc aggagttcca   3360

gaccagcctg gccaacatgg tgaaatccca tctctacaaa aataaaacag ttagctgggc   3420

atgatggcgg gtgcctgtaa tcccagctac tcgggaggct gaggcaggat agtcgcttga   3480

acccaggagg tggaggttgc aatgagccaa gatcatgcca ctgcactcca gcctggacga   3540

cagagtgaga ctccatcaca agaaaaaaag aactttgtca acctctgtct tagggcgcct   3600

tgtcacaggc ttcgggtcag acggattcaa ccttgcatca gccatttgtt agccaggtca   3660

ctctgttctt tgtctgtaaa tgagattgat cgttgttccc actgagagtg tcagctcctt   3720

cccgtagagc aggcatgatg attgtactca cctctgacac cattgtgagt gccacattcc   3780

ttcccacgtc cttgtcactg taagagatgc ccacctgagc accaacccca ggttatcttc   3840

ccctttgtct tccagccccc cagaaacagc tacgactcaa cctacccaat catttcatca   3900

tcagattgcc actgtctcta gttcaggtct cttgggactg gcactcagaa atctcataat   3960

aaatcctctt gaggcttctc atacactcgt cttcttccaa tcttctttcc ctcaaaatct   4020

catattttgg ttccacttca cccaccgtca ttctccatat cactcccagg agttaggcaa   4080

aaagcccctt ccgttcttcc gtatgttaaa cttagaatca ctctgttccc tgctctgcgt   4140

ttctattttt tgtttttcct ccatttacta gtagcttaac actttctaac agtgttctta   4200

ttattgatac gtatctatct cttccataag cttataaggt cacggataat acttctcatt   4260

gtagtacgta aatgacgtgg gctagatatg agttgaataa acagttatac ctgtaaattc   4320

ttacagagtg aaaataaatt gttatacttt acaatttgtt tctctcttta gaccatttcc   4380

aggacttgtg attaataacc gtgagtattt tgtgaagtgt tttgtttttg ttttttcctg   4440

gggtctgacg tgtgtgcgtg tgagtgtgta tacatgctta acgtatatca cgttacttca   4500

cctatgtcag taaccaggcc aaatacttgt tttagccctc agtaaaaaca ccaggcactt   4560

cctagttgta aaattattca agcttcttaa cttcctatcc tcgatgcact taatcataaa   4620

atggtaataa tagcaccgat tttgggggag tcgttccagt agatggaaag catctggaac   4680

aggtgtcagc aagctcctgc cgacgtgtat gcataaagtt ttattgaaac caccatcgtg   4740

tccatttgtt tatggcagaa ctgagagatg gcagcagcaa gtgtgtgcct gcaaaaccta   4800

aaatatttac taattggctc tgcaagaaaa gagtttgcat ccccctaacc tagaacagtg   4860

tctagcctct agtatgtgtt tagcctacag tatgtgctca gcgaatacaa tctatattta   4920

ttactgcttt tatgactgtt ataattactg tgcttggatt tcgttacaaa gtaagtcaca   4980

atgtgcctgc ttctgttagt atttcagcac agtgcctggc acacatgggg ctctcaaata   5040

ttgctgagcg agtgaacaaa tgtcctttca attccttaac gttgatgtca ttttcaatag   5100

tattttgagc caaacttaat tttgcgagtg tgttttgttt tcttaacttt attattaaaa   5160

atgtataaaa gtgaggccag gcgtggtggc tcacgcctgt aatcccagca gtttgggagg   5220

ctgaggcagg cggatcagtt gaggttggga gttggagacc agcccgtcca acatggtgaa   5280

agcctgtctc tactaaaaat acaaaaatca gctgggtgtg gtggcgcgtg cctgtaatcc   5340

cagctactca ggaggctgag gcaggagagt tgcttgaatc ctagaggtgg aggttgcagt   5400

gagctgagat cgtgccattg cactccagcc tgggcaacaa gagcaaaact ctgtcccaat   5460

aaataaataa ataaaatgtt ctcttttgtt cctgttcttg tgcggtagtg tggtatagag   5520

ttttatggta attactgtga attagtgatt ctgagggaca tatcagaact ctgaggtttg   5580

tttccttctc atcttgaggg aaacagcaaa tgtatgttaa aatgcttttc caagggaaca   5640

acacatcctt acattattta aaccaatctg cttcattttc agagctggtt gatcagagtg   5700

agtcagaagg ccccgtgata caagaatcag ctgaaccaag ccagttggaa gttccagcca   5760

cagaagaaat aaaagagact gatggaagct ctcagatcaa gcaagaacca gaccccacgt   5820

ggtagacctc ttccctccta ggcttaaagt atcagtggtt gagaagagct tttcggacct   5880

gttactaccc caagctgtgt aatatacttg tataacagaa ataccttcta tacaaacctt   5940

tttttctact tttagataga aatgtctact ttttcagcag ttctgtgaat taaagagcag   6000

agtgactgtg ggtctggaat ggctggtgta cttgggaatg tactatcagg attttacagc   6060

aatgctggga aatgacaggg aaaatgacag gaatgaatct caccagattt tttatgtact   6120

cagcagagcc ttgagttacg gtgtttattt tccaatcaag tgaagatatc tcctacttct   6180

cctactggaa catctcagct tctgcagtga agaaaaattc ctgtgatagt tcagttcttt   6240

agtttttcta tttgaaaaaa aaaaatcatt taaatgatcc tttgttcacg gctctcctta   6300

atgactgagt gaacagttcc tatctgtata tttgactaaa ccttttccta agctatctct   6360

catggttcct atgttttttt atcataatta aaagcaaaac catctggatc acctaacagt   6420

cagaggtcag tatctcagcg tgtgaattat agaggaaata cagagagaac ctcttccact   6480

tttacttttc gtccaaataa aatgcatggt gtaccagaag ttgaagatcg ggttgaggat   6540

tggggctagc tcgatgacac taaggcccca acatcgcggg acctgctgtg gcgcggattc   6600

ttaggaacgc tgttctagcc ggccccctct ccaggggtcg ccgtggccgg cattatttcc   6660

tagttcttct tgtaaccctg aggtgccagc gcggggagtg aggaggggtc agggggctaa   6720

ggatgcaacc tctgacgttc tgcgccttcc taggagagtc ttacatgtgt tgagatttca   6780

caagcaatgc gagttgtaaa ataccagctc tacaagaagc taggctctgt gacggcatag   6840

ttttcagtag ctttatcaca atattcacaa tggagaatta tatgacatgg tagcagaaat   6900

aggccctttt atgtgttgct tctattttac ctcaaattgt agatataggg taatcaataa   6960

aatccatcca tgcctttcac acactaagt                                     6989


<210>  5131
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  5131

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
                565                 570                 575


Ser Ser Leu Leu Lys Asn Leu Asn 
            580


<210>  5132
<211>  5222
<212>  DNA
<213>  Homo sapiens

<400>  5132
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   2040

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2100

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2160

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2220

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2280

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2340

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2400

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2460

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2520

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2580

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2640

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2700

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2760

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2820

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2880

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   2940

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   3000

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3060

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3120

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3180

ttcacggtca ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt   3240

gagtcagaag gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc   3300

acagaagaaa taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg   3360

tggtagacct cttccctcct agggtaaatc agcttctgtg tcagggatgc tgtgtggtgt   3420

ccatctgaac cccctgcata cgcgtagcta atgtgatctc cccactttca cataagatgg   3480

tggccctgcc ttcagggaat gtgggagcca ggtgggagcc ttcccggata tttaagctag   3540

aagattctac agggagattc tccttggatc aatatatgtc tctcagtcaa agatgtaaaa   3600

gcacttttgc cttaaaaaga atgttctgtt tctaaataga gtcaacgttg tcctcctcat   3660

tggaattcac tatgagtcag aatcattaga ctgacttttt tttttccata gtaatagtat   3720

tttgcagagt ctcacagagc tgcagatctt ttgttcatct tgcagagtta acaagtctga   3780

tcctgttagt ccagatttct taaatttggc caagttataa taggagcagt agcttgagac   3840

ccgaagtcag gaaactttga caatggattt ttttttttaa tccagagact tgtactggaa   3900

tttgccttac cctgtcagct catggactta aggtttcatc ccgctttatg agtgcttctg   3960

aatccaagtc attgttacct gaatttgcaa attaagttgt gatattcgtg actgttaaat   4020

tcctgtaatt agattaacct ctttgcttgc ttgtttgttt tctctcctat tttagcttaa   4080

agtatcagtg gttgagaaga gcttttcgga cctgttacta ccccaagctg tgtaatatac   4140

ttgtataaca gaaatacctt ctatacaaac ctttttttct acttttagat agaaatgtct   4200

actttttcag cagttctgtg aattaaagag cagagtgact gtgggtctgg aatggctggt   4260

gtacttggga atgtactatc aggattttac agcaatgctg ggaaatgaca gggaaaatga   4320

caggaatgaa tctcaccaga ttttttatgt actcagcaga gccttgagtt acggtgttta   4380

ttttccaatc aagtgaagat atctcctact tctcctactg gaacatctca gcttctgcag   4440

tgaagaaaaa ttcctgtgat agttcagttc tttagttttt ctatttgaaa aaaaaaaatc   4500

atttaaatga tcctttgttc acggctctcc ttaatgactg agtgaacagt tcctatctgt   4560

atatttgact aaaccttttc ctaagctatc tctcatggtt cctatgtttt tttatcataa   4620

ttaaaagcaa aaccatctgg atcacctaac agtcagaggt cagtatctca gcgtgtgaat   4680

tatagaggaa atacagagag aacctcttcc acttttactt ttcgtccaaa taaaatgcat   4740

ggtgtaccag aagttgaaga tcgggttgag gattggggct agctcgatga cactaaggcc   4800

ccaacatcgc gggacctgct gtggcgcgga ttcttaggaa cgctgttcta gccggccccc   4860

tctccagggg tcgccgtggc cggcattatt tcctagttct tcttgtaacc ctgaggtgcc   4920

agcgcgggga gtgaggaggg gtcagggggc taaggatgca acctctgacg ttctgcgcct   4980

tcctaggaga gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt aaaataccag   5040

ctctacaaga agctaggctc tgtgacggca tagttttcag tagctttatc acaatattca   5100

caatggagaa ttatatgaca tggtagcaga aataggccct tttatgtgtt gcttctattt   5160

tacctcaaat tgtagatata gggtaatcaa taaaatccat ccatgccttt cacacactaa   5220

gt                                                                  5222


<210>  5133
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  5133

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala 
            580


<210>  5134
<211>  3995
<212>  DNA
<213>  Homo sapiens

<400>  5134
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1080

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1140

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1200

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1260

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1320

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1380

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1440

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1500

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1560

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1620

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1680

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1740

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1800

cgaatacacc agctcaagct cttggactca ccgaggcagt aaaagtacca tatcctgtgt   1860

ttgaatcaaa cccggagttc ttgtatgtgg aaggcttgcc agaggggatt cccttccgaa   1920

gccctacctg gtttggaatt ccacgacttg aaaggatcgt ccgcgggagt aataaaatca   1980

agttcgttgt taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta   2040

aaataaacac taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa   2100

aggttcctga aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag   2160

ctgttcgaac cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag   2220

agttttcctt tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc   2280

tcttcaatga gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg   2340

cgttatttga gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat   2400

tccgaagacc atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca   2460

aaattaagtt catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct   2520

cctctaagag ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag   2580

gtgttgaaga ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct   2640

cgaaagttga aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat   2700

ttggtgaagc tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta   2760

accctggctg tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct   2820

acctggaaat cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg   2880

tcattagacc atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag   2940

aaggccccgt gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag   3000

aaataaaaga gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga   3060

cctcttccct cctaggctta aagtatcagt ggttgagaag agcttttcgg acctgttact   3120

accccaagct gtagccttga gttacggtgt ttattttcca atcaagtgaa gatatctcct   3180

acttctccta ctggaacatc tcagcttctg cagtgaagaa aaattcctgt gatagttcag   3240

ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa tgatcctttg ttcacggctc   3300

tccttaatga ctgagtgaac agttcctatc tgtatatttg actaaacctt ttcctaagct   3360

atctctcatg gttcctatgt ttttttatca taattaaaag caaaaccatc tggatcacct   3420

aacagtcaga ggtcagtatc tcagcgtgtg aattatagag gaaatacaga gagaacctct   3480

tccactttta cttttcgtcc aaataaaatg catggtgtac cagaagttga agatcgggtt   3540

gaggattggg gctagctcga tgacactaag gccccaacat cgcgggacct gctgtggcgc   3600

ggattcttag gaacgctgtt ctagccggcc ccctctccag gggtcgccgt ggccggcatt   3660

atttcctagt tcttcttgta accctgaggt gccagcgcgg ggagtgagga ggggtcaggg   3720

ggctaaggat gcaacctctg acgttctgcg ccttcctagg agagtcttac atgtgttgag   3780

atttcacaag caatgcgagt tgtaaaatac cagctctaca agaagctagg ctctgtgacg   3840

gcatagtttt cagtagcttt atcacaatat tcacaatgga gaattatatg acatggtagc   3900

agaaataggc ccttttatgt gttgcttcta ttttacctca aattgtagat atagggtaat   3960

caataaaatc catccatgcc tttcacacac taagt                              3995


<210>  5135
<211>  933
<212>  PRT
<213>  Homo sapiens

<400>  5135

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
        515                 520                 525


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
    530                 535                 540


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
545                 550                 555                 560


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
                565                 570                 575


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
            580                 585                 590


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
        595                 600                 605


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
    610                 615                 620


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
625                 630                 635                 640


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
                645                 650                 655


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
            660                 665                 670


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
        675                 680                 685


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
    690                 695                 700


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
705                 710                 715                 720


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
                725                 730                 735


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
            740                 745                 750


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
        755                 760                 765


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
    770                 775                 780


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
785                 790                 795                 800


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
                805                 810                 815


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
            820                 825                 830


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
        835                 840                 845


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
    850                 855                 860


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro 
865                 870                 875                 880


Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly 
                885                 890                 895


Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala 
            900                 905                 910


Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu 
        915                 920                 925


Pro Asp Pro Thr Trp 
    930


<210>  5136
<211>  7179
<212>  DNA
<213>  Homo sapiens

<400>  5136
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040

taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2100

ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2160

ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2220

ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2280

ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2340

atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2400

agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2460

agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2520

tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2580

ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2640

tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2700

ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2760

atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2820

ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2880

tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   2940

ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   3000

tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3060

ttatcaaatt cacggtcatt aggtaagtga gagtttcctg cttagtcaca ggagcgaatc   3120

tggagctcat gaggctgact cttctaaaat gcagccacag gtagtcatcg aatccggctt   3180

cctatgctgt gcaatcaaca aatcaaaata acttgtgtca tcattagaat gtcagatgtg   3240

cttctacgaa ctaagctgac tcttttaatt ctttggcaaa gggttggcaa actaggactg   3300

tttgccaaat tcaggctgcc tcctattttt agagtcttcc tgaaacacag ctacacccgt   3360

attatccatg gctgctttcc tgtcacagtg agtaagtagc tgggactgag aaggcatggc   3420

ctccaaagtc taaaatattt actctctagc actttgtaga aaaaccttag ctaggcacag   3480

tggctaacgc ctgtaatccc agcattttgg gaggccaagg caggcagatc acctgaggtc   3540

aggagttcca gaccagcctg gccaacatgg tgaaatccca tctctacaaa aataaaacag   3600

ttagctgggc atgatggcgg gtgcctgtaa tcccagctac tcgggaggct gaggcaggat   3660

agtcgcttga acccaggagg tggaggttgc aatgagccaa gatcatgcca ctgcactcca   3720

gcctggacga cagagtgaga ctccatcaca agaaaaaaag aactttgtca acctctgtct   3780

tagggcgcct tgtcacaggc ttcgggtcag acggattcaa ccttgcatca gccatttgtt   3840

agccaggtca ctctgttctt tgtctgtaaa tgagattgat cgttgttccc actgagagtg   3900

tcagctcctt cccgtagagc aggcatgatg attgtactca cctctgacac cattgtgagt   3960

gccacattcc ttcccacgtc cttgtcactg taagagatgc ccacctgagc accaacccca   4020

ggttatcttc ccctttgtct tccagccccc cagaaacagc tacgactcaa cctacccaat   4080

catttcatca tcagattgcc actgtctcta gttcaggtct cttgggactg gcactcagaa   4140

atctcataat aaatcctctt gaggcttctc atacactcgt cttcttccaa tcttctttcc   4200

ctcaaaatct catattttgg ttccacttca cccaccgtca ttctccatat cactcccagg   4260

agttaggcaa aaagcccctt ccgttcttcc gtatgttaaa cttagaatca ctctgttccc   4320

tgctctgcgt ttctattttt tgtttttcct ccatttacta gtagcttaac actttctaac   4380

agtgttctta ttattgatac gtatctatct cttccataag cttataaggt cacggataat   4440

acttctcatt gtagtacgta aatgacgtgg gctagatatg agttgaataa acagttatac   4500

ctgtaaattc ttacagagtg aaaataaatt gttatacttt acaatttgtt tctctcttta   4560

gaccatttcc aggacttgtg attaataacc gtgagtattt tgtgaagtgt tttgtttttg   4620

ttttttcctg gggtctgacg tgtgtgcgtg tgagtgtgta tacatgctta acgtatatca   4680

cgttacttca cctatgtcag taaccaggcc aaatacttgt tttagccctc agtaaaaaca   4740

ccaggcactt cctagttgta aaattattca agcttcttaa cttcctatcc tcgatgcact   4800

taatcataaa atggtaataa tagcaccgat tttgggggag tcgttccagt agatggaaag   4860

catctggaac aggtgtcagc aagctcctgc cgacgtgtat gcataaagtt ttattgaaac   4920

caccatcgtg tccatttgtt tatggcagaa ctgagagatg gcagcagcaa gtgtgtgcct   4980

gcaaaaccta aaatatttac taattggctc tgcaagaaaa gagtttgcat ccccctaacc   5040

tagaacagtg tctagcctct agtatgtgtt tagcctacag tatgtgctca gcgaatacaa   5100

tctatattta ttactgcttt tatgactgtt ataattactg tgcttggatt tcgttacaaa   5160

gtaagtcaca atgtgcctgc ttctgttagt atttcagcac agtgcctggc acacatgggg   5220

ctctcaaata ttgctgagcg agtgaacaaa tgtcctttca attccttaac gttgatgtca   5280

ttttcaatag tattttgagc caaacttaat tttgcgagtg tgttttgttt tcttaacttt   5340

attattaaaa atgtataaaa gtgaggccag gcgtggtggc tcacgcctgt aatcccagca   5400

gtttgggagg ctgaggcagg cggatcagtt gaggttggga gttggagacc agcccgtcca   5460

acatggtgaa agcctgtctc tactaaaaat acaaaaatca gctgggtgtg gtggcgcgtg   5520

cctgtaatcc cagctactca ggaggctgag gcaggagagt tgcttgaatc ctagaggtgg   5580

aggttgcagt gagctgagat cgtgccattg cactccagcc tgggcaacaa gagcaaaact   5640

ctgtcccaat aaataaataa ataaaatgtt ctcttttgtt cctgttcttg tgcggtagtg   5700

tggtatagag ttttatggta attactgtga attagtgatt ctgagggaca tatcagaact   5760

ctgaggtttg tttccttctc atcttgaggg aaacagcaaa tgtatgttaa aatgcttttc   5820

caagggaaca acacatcctt acattattta aaccaatctg cttcattttc agagctggtt   5880

gatcagagtg agtcagaagg ccccgtgata caagaatcag ctgaaccaag ccagttggaa   5940

gttccagcca cagaagaaat aaaagagact gatggaagct ctcagatcaa gcaagaacca   6000

gaccccacgt ggtagacctc ttccctccta ggcttaaagt atcagtggtt gagaagagct   6060

tttcggacct gttactaccc caagctgtgt aatatacttg tataacagaa ataccttcta   6120

tacaaacctt tttttctact tttagataga aatgtctact ttttcagcag ttctgtgaat   6180

taaagagcag agtgactgtg ggtctggaat ggctggtgta cttgggaatg tactatcagg   6240

attttacagc aatgctggga aatgacaggg aaaatgacag gaatgaatct caccagattt   6300

tttatgtact cagcagagcc ttgagttacg gtgtttattt tccaatcaag tgaagatatc   6360

tcctacttct cctactggaa catctcagct tctgcagtga agaaaaattc ctgtgatagt   6420

tcagttcttt agtttttcta tttgaaaaaa aaaaatcatt taaatgatcc tttgttcacg   6480

gctctcctta atgactgagt gaacagttcc tatctgtata tttgactaaa ccttttccta   6540

agctatctct catggttcct atgttttttt atcataatta aaagcaaaac catctggatc   6600

acctaacagt cagaggtcag tatctcagcg tgtgaattat agaggaaata cagagagaac   6660

ctcttccact tttacttttc gtccaaataa aatgcatggt gtaccagaag ttgaagatcg   6720

ggttgaggat tggggctagc tcgatgacac taaggcccca acatcgcggg acctgctgtg   6780

gcgcggattc ttaggaacgc tgttctagcc ggccccctct ccaggggtcg ccgtggccgg   6840

cattatttcc tagttcttct tgtaaccctg aggtgccagc gcggggagtg aggaggggtc   6900

agggggctaa ggatgcaacc tctgacgttc tgcgccttcc taggagagtc ttacatgtgt   6960

tgagatttca caagcaatgc gagttgtaaa ataccagctc tacaagaagc taggctctgt   7020

gacggcatag ttttcagtag ctttatcaca atattcacaa tggagaatta tatgacatgg   7080

tagcagaaat aggccctttt atgtgttgct tctattttac ctcaaattgt agatataggg   7140

taatcaataa aatccatcca tgcctttcac acactaagt                          7179


<210>  5137
<211>  942
<212>  PRT
<213>  Homo sapiens

<400>  5137

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr 
        595                 600                 605


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe 
    610                 615                 620


Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys 
625                 630                 635                 640


Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly 
                645                 650                 655


Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro 
            660                 665                 670


Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val 
        675                 680                 685


Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro 
    690                 695                 700


Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu 
705                 710                 715                 720


Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys 
                725                 730                 735


Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys 
            740                 745                 750


Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp 
        755                 760                 765


Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser 
    770                 775                 780


Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys 
785                 790                 795                 800


Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys 
                805                 810                 815


Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro 
            820                 825                 830


Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln 
        835                 840                 845


Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys 
    850                 855                 860


Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe 
865                 870                 875                 880


Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys 
                885                 890                 895


Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly 
            900                 905                 910


Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg 
        915                 920                 925


Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
    930                 935                 940


<210>  5138
<211>  7228
<212>  DNA
<213>  Homo sapiens

<400>  5138
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgcttaga tttgttgaca gcggtttcct ggagtgctgt   1980

cttgagaacg attctgagga ggctcagcaa gaaagagtgt ttcagttgat tgggtgtgtc   2040

tgtcatggag aaggaactca agctcttgga ctcaccgagg cagtaaaagt accatatcct   2100

gtgtttgaat caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc   2160

cgaagcccta cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa   2220

atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct   2280

agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat   2340

tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc   2400

tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg   2460

agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa   2520

aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg   2580

ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg   2640

ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa   2700

gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc   2760

acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca   2820

tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga   2880

ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg   2940

aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca   3000

attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt caaagccccc   3060

agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc   3120

acggtcatta ggtaagtgag agtttcctgc ttagtcacag gagcgaatct ggagctcatg   3180

aggctgactc ttctaaaatg cagccacagg tagtcatcga atccggcttc ctatgctgtg   3240

caatcaacaa atcaaaataa cttgtgtcat cattagaatg tcagatgtgc ttctacgaac   3300

taagctgact cttttaattc tttggcaaag ggttggcaaa ctaggactgt ttgccaaatt   3360

caggctgcct cctattttta gagtcttcct gaaacacagc tacacccgta ttatccatgg   3420

ctgctttcct gtcacagtga gtaagtagct gggactgaga aggcatggcc tccaaagtct   3480

aaaatattta ctctctagca ctttgtagaa aaaccttagc taggcacagt ggctaacgcc   3540

tgtaatccca gcattttggg aggccaaggc aggcagatca cctgaggtca ggagttccag   3600

accagcctgg ccaacatggt gaaatcccat ctctacaaaa ataaaacagt tagctgggca   3660

tgatggcggg tgcctgtaat cccagctact cgggaggctg aggcaggata gtcgcttgaa   3720

cccaggaggt ggaggttgca atgagccaag atcatgccac tgcactccag cctggacgac   3780

agagtgagac tccatcacaa gaaaaaaaga actttgtcaa cctctgtctt agggcgcctt   3840

gtcacaggct tcgggtcaga cggattcaac cttgcatcag ccatttgtta gccaggtcac   3900

tctgttcttt gtctgtaaat gagattgatc gttgttccca ctgagagtgt cagctccttc   3960

ccgtagagca ggcatgatga ttgtactcac ctctgacacc attgtgagtg ccacattcct   4020

tcccacgtcc ttgtcactgt aagagatgcc cacctgagca ccaaccccag gttatcttcc   4080

cctttgtctt ccagcccccc agaaacagct acgactcaac ctacccaatc atttcatcat   4140

cagattgcca ctgtctctag ttcaggtctc ttgggactgg cactcagaaa tctcataata   4200

aatcctcttg aggcttctca tacactcgtc ttcttccaat cttctttccc tcaaaatctc   4260

atattttggt tccacttcac ccaccgtcat tctccatatc actcccagga gttaggcaaa   4320

aagccccttc cgttcttccg tatgttaaac ttagaatcac tctgttccct gctctgcgtt   4380

tctatttttt gtttttcctc catttactag tagcttaaca ctttctaaca gtgttcttat   4440

tattgatacg tatctatctc ttccataagc ttataaggtc acggataata cttctcattg   4500

tagtacgtaa atgacgtggg ctagatatga gttgaataaa cagttatacc tgtaaattct   4560

tacagagtga aaataaattg ttatacttta caatttgttt ctctctttag accatttcca   4620

ggacttgtga ttaataaccg tgagtatttt gtgaagtgtt ttgtttttgt tttttcctgg   4680

ggtctgacgt gtgtgcgtgt gagtgtgtat acatgcttaa cgtatatcac gttacttcac   4740

ctatgtcagt aaccaggcca aatacttgtt ttagccctca gtaaaaacac caggcacttc   4800

ctagttgtaa aattattcaa gcttcttaac ttcctatcct cgatgcactt aatcataaaa   4860

tggtaataat agcaccgatt ttgggggagt cgttccagta gatggaaagc atctggaaca   4920

ggtgtcagca agctcctgcc gacgtgtatg cataaagttt tattgaaacc accatcgtgt   4980

ccatttgttt atggcagaac tgagagatgg cagcagcaag tgtgtgcctg caaaacctaa   5040

aatatttact aattggctct gcaagaaaag agtttgcatc cccctaacct agaacagtgt   5100

ctagcctcta gtatgtgttt agcctacagt atgtgctcag cgaatacaat ctatatttat   5160

tactgctttt atgactgtta taattactgt gcttggattt cgttacaaag taagtcacaa   5220

tgtgcctgct tctgttagta tttcagcaca gtgcctggca cacatggggc tctcaaatat   5280

tgctgagcga gtgaacaaat gtcctttcaa ttccttaacg ttgatgtcat tttcaatagt   5340

attttgagcc aaacttaatt ttgcgagtgt gttttgtttt cttaacttta ttattaaaaa   5400

tgtataaaag tgaggccagg cgtggtggct cacgcctgta atcccagcag tttgggaggc   5460

tgaggcaggc ggatcagttg aggttgggag ttggagacca gcccgtccaa catggtgaaa   5520

gcctgtctct actaaaaata caaaaatcag ctgggtgtgg tggcgcgtgc ctgtaatccc   5580

agctactcag gaggctgagg caggagagtt gcttgaatcc tagaggtgga ggttgcagtg   5640

agctgagatc gtgccattgc actccagcct gggcaacaag agcaaaactc tgtcccaata   5700

aataaataaa taaaatgttc tcttttgttc ctgttcttgt gcggtagtgt ggtatagagt   5760

tttatggtaa ttactgtgaa ttagtgattc tgagggacat atcagaactc tgaggtttgt   5820

ttccttctca tcttgaggga aacagcaaat gtatgttaaa atgcttttcc aagggaacaa   5880

cacatcctta cattatttaa accaatctgc ttcattttca gagctggttg atcagagtga   5940

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   6000

agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag accccacgtg   6060

gtagacctct tccctcctag gcttaaagta tcagtggttg agaagagctt ttcggacctg   6120

ttactacccc aagctgtgta atatacttgt ataacagaaa taccttctat acaaaccttt   6180

ttttctactt ttagatagaa atgtctactt tttcagcagt tctgtgaatt aaagagcaga   6240

gtgactgtgg gtctggaatg gctggtgtac ttgggaatgt actatcagga ttttacagca   6300

atgctgggaa atgacaggga aaatgacagg aatgaatctc accagatttt ttatgtactc   6360

agcagagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct cctacttctc   6420

ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta   6480

gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg ctctccttaa   6540

tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa gctatctctc   6600

atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca cctaacagtc   6660

agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc tcttccactt   6720

ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg gttgaggatt   6780

ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg cgcggattct   6840

taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc attatttcct   6900

agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca gggggctaag   6960

gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt gagatttcac   7020

aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg acggcatagt   7080

tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt agcagaaata   7140

ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt aatcaataaa   7200

atccatccat gcctttcaca cactaagt                                      7228


<210>  5139
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  5139

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala 



<210>  5140
<211>  7052
<212>  DNA
<213>  Homo sapiens

<400>  5140
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1080

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1140

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1200

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1260

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1320

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1380

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1440

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1500

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1560

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1620

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1680

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1740

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1800

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1860

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1920

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   1980

taccatatcc tgtgtttgaa tcaaacccgg agttcttgaa aggatcgtcc gcgggagtaa   2040

taaaatcaag ttcgttgtta aaaaacctga actagttatt tcctacttgc ctcctgggat   2100

ggctagtaaa ataaacacta aagctttgca gtcccccaaa agaccacgaa gtcctgggag   2160

taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc cctaataaca acaatcctca   2220

aacctcagct gttcgaaccc cgacccagac taacggttct aacgttccct tcaagccacg   2280

agggagagag ttttcctttg aggcctggaa tgccaaaatc acggacctaa aacagaaagt   2340

tgaaaatctc ttcaatgaga aatgtgggga agctcttggc cttaaacaag ctgtgaaggt   2400

gccgttcgcg ttatttgagt ctttcccgga agacttttat gtggaaggct tacctgaggg   2460

tgtgccattc cgaagaccat cgacttttgg cattccgagg ctggagaaga tactcagaaa   2520

caaagccaaa attaagttca tcattaaaaa gcccgaaatg tttgagacgg cgattaagga   2580

gagcacctcc tctaagagcc ctcccagaaa aataaattca tcacccaatg ttaatactac   2640

tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca attccagatg atgataatga   2700

aagactctcg aaagttgaaa aagctagaca gctaagagaa caagtgaatg acctctttag   2760

tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg aaagttccct acaggaaaat   2820

cacaattaac cctggctgtg tggtggttga tggcatgccc ccgggggtgt ccttcaaagc   2880

ccccagctac ctggaaatca gctccatgag aaggatctta gactctgccg agtttatcaa   2940

attcacggtc attaggtaag tgagagtttc ctgcttagtc acaggagcga atctggagct   3000

catgaggctg actcttctaa aatgcagcca caggtagtca tcgaatccgg cttcctatgc   3060

tgtgcaatca acaaatcaaa ataacttgtg tcatcattag aatgtcagat gtgcttctac   3120

gaactaagct gactctttta attctttggc aaagggttgg caaactagga ctgtttgcca   3180

aattcaggct gcctcctatt tttagagtct tcctgaaaca cagctacacc cgtattatcc   3240

atggctgctt tcctgtcaca gtgagtaagt agctgggact gagaaggcat ggcctccaaa   3300

gtctaaaata tttactctct agcactttgt agaaaaacct tagctaggca cagtggctaa   3360

cgcctgtaat cccagcattt tgggaggcca aggcaggcag atcacctgag gtcaggagtt   3420

ccagaccagc ctggccaaca tggtgaaatc ccatctctac aaaaataaaa cagttagctg   3480

ggcatgatgg cgggtgcctg taatcccagc tactcgggag gctgaggcag gatagtcgct   3540

tgaacccagg aggtggaggt tgcaatgagc caagatcatg ccactgcact ccagcctgga   3600

cgacagagtg agactccatc acaagaaaaa aagaactttg tcaacctctg tcttagggcg   3660

ccttgtcaca ggcttcgggt cagacggatt caaccttgca tcagccattt gttagccagg   3720

tcactctgtt ctttgtctgt aaatgagatt gatcgttgtt cccactgaga gtgtcagctc   3780

cttcccgtag agcaggcatg atgattgtac tcacctctga caccattgtg agtgccacat   3840

tccttcccac gtccttgtca ctgtaagaga tgcccacctg agcaccaacc ccaggttatc   3900

ttcccctttg tcttccagcc ccccagaaac agctacgact caacctaccc aatcatttca   3960

tcatcagatt gccactgtct ctagttcagg tctcttggga ctggcactca gaaatctcat   4020

aataaatcct cttgaggctt ctcatacact cgtcttcttc caatcttctt tccctcaaaa   4080

tctcatattt tggttccact tcacccaccg tcattctcca tatcactccc aggagttagg   4140

caaaaagccc cttccgttct tccgtatgtt aaacttagaa tcactctgtt ccctgctctg   4200

cgtttctatt ttttgttttt cctccattta ctagtagctt aacactttct aacagtgttc   4260

ttattattga tacgtatcta tctcttccat aagcttataa ggtcacggat aatacttctc   4320

attgtagtac gtaaatgacg tgggctagat atgagttgaa taaacagtta tacctgtaaa   4380

ttcttacaga gtgaaaataa attgttatac tttacaattt gtttctctct ttagaccatt   4440

tccaggactt gtgattaata accgtgagta ttttgtgaag tgttttgttt ttgttttttc   4500

ctggggtctg acgtgtgtgc gtgtgagtgt gtatacatgc ttaacgtata tcacgttact   4560

tcacctatgt cagtaaccag gccaaatact tgttttagcc ctcagtaaaa acaccaggca   4620

cttcctagtt gtaaaattat tcaagcttct taacttccta tcctcgatgc acttaatcat   4680

aaaatggtaa taatagcacc gattttgggg gagtcgttcc agtagatgga aagcatctgg   4740

aacaggtgtc agcaagctcc tgccgacgtg tatgcataaa gttttattga aaccaccatc   4800

gtgtccattt gtttatggca gaactgagag atggcagcag caagtgtgtg cctgcaaaac   4860

ctaaaatatt tactaattgg ctctgcaaga aaagagtttg catcccccta acctagaaca   4920

gtgtctagcc tctagtatgt gtttagccta cagtatgtgc tcagcgaata caatctatat   4980

ttattactgc ttttatgact gttataatta ctgtgcttgg atttcgttac aaagtaagtc   5040

acaatgtgcc tgcttctgtt agtatttcag cacagtgcct ggcacacatg gggctctcaa   5100

atattgctga gcgagtgaac aaatgtcctt tcaattcctt aacgttgatg tcattttcaa   5160

tagtattttg agccaaactt aattttgcga gtgtgttttg ttttcttaac tttattatta   5220

aaaatgtata aaagtgaggc caggcgtggt ggctcacgcc tgtaatccca gcagtttggg   5280

aggctgaggc aggcggatca gttgaggttg ggagttggag accagcccgt ccaacatggt   5340

gaaagcctgt ctctactaaa aatacaaaaa tcagctgggt gtggtggcgc gtgcctgtaa   5400

tcccagctac tcaggaggct gaggcaggag agttgcttga atcctagagg tggaggttgc   5460

agtgagctga gatcgtgcca ttgcactcca gcctgggcaa caagagcaaa actctgtccc   5520

aataaataaa taaataaaat gttctctttt gttcctgttc ttgtgcggta gtgtggtata   5580

gagttttatg gtaattactg tgaattagtg attctgaggg acatatcaga actctgaggt   5640

ttgtttcctt ctcatcttga gggaaacagc aaatgtatgt taaaatgctt ttccaaggga   5700

acaacacatc cttacattat ttaaaccaat ctgcttcatt ttcagagctg gttgatcaga   5760

gtgagtcaga aggccccgtg atacaagaat cagctgaacc aagccagttg gaagttccag   5820

ccacagaaga aataaaagag actgatggaa gctctcagat caagcaagaa ccagacccca   5880

cgtggtagac ctcttccctc ctaggcttaa agtatcagtg gttgagaaga gcttttcgga   5940

cctgttacta ccccaagctg tgtaatatac ttgtataaca gaaatacctt ctatacaaac   6000

ctttttttct acttttagat agaaatgtct actttttcag cagttctgtg aattaaagag   6060

cagagtgact gtgggtctgg aatggctggt gtacttggga atgtactatc aggattttac   6120

agcaatgctg ggaaatgaca gggaaaatga caggaatgaa tctcaccaga ttttttatgt   6180

actcagcaga gccttgagtt acggtgttta ttttccaatc aagtgaagat atctcctact   6240

tctcctactg gaacatctca gcttctgcag tgaagaaaaa ttcctgtgat agttcagttc   6300

tttagttttt ctatttgaaa aaaaaaaatc atttaaatga tcctttgttc acggctctcc   6360

ttaatgactg agtgaacagt tcctatctgt atatttgact aaaccttttc ctaagctatc   6420

tctcatggtt cctatgtttt tttatcataa ttaaaagcaa aaccatctgg atcacctaac   6480

agtcagaggt cagtatctca gcgtgtgaat tatagaggaa atacagagag aacctcttcc   6540

acttttactt ttcgtccaaa taaaatgcat ggtgtaccag aagttgaaga tcgggttgag   6600

gattggggct agctcgatga cactaaggcc ccaacatcgc gggacctgct gtggcgcgga   6660

ttcttaggaa cgctgttcta gccggccccc tctccagggg tcgccgtggc cggcattatt   6720

tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc   6780

taaggatgca acctctgacg ttctgcgcct tcctaggaga gtcttacatg tgttgagatt   6840

tcacaagcaa tgcgagttgt aaaataccag ctctacaaga agctaggctc tgtgacggca   6900

tagttttcag tagctttatc acaatattca caatggagaa ttatatgaca tggtagcaga   6960

aataggccct tttatgtgtt gcttctattt tacctcaaat tgtagatata gggtaatcaa   7020

taaaatccat ccatgccttt cacacactaa gt                                 7052


<210>  5141
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  5141

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala 
            580                 585                 590


Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600                 605


<210>  5142
<211>  7231
<212>  DNA
<213>  Homo sapiens

<400>  5142
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1080

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1140

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1200

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1260

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1320

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1380

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1440

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1500

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1560

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1620

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1680

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1740

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1800

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1860

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1920

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   1980

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2040

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2100

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2160

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2220

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2280

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2340

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2400

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2460

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2520

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2580

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2640

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2700

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2760

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2820

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   2880

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   2940

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3000

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3060

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3120

ttcacggtca ttaggtaagt gagagtttcc tgcttagtca caggagcgaa tctggagctc   3180

atgaggctga ctcttctaaa atgcagccac aggtagtcat cgaatccggc ttcctatgct   3240

gtgcaatcaa caaatcaaaa taacttgtgt catcattaga atgtcagatg tgcttctacg   3300

aactaagctg actcttttaa ttctttggca aagggttggc aaactaggac tgtttgccaa   3360

attcaggctg cctcctattt ttagagtctt cctgaaacac agctacaccc gtattatcca   3420

tggctgcttt cctgtcacag tgagtaagta gctgggactg agaaggcatg gcctccaaag   3480

tctaaaatat ttactctcta gcactttgta gaaaaacctt agctaggcac agtggctaac   3540

gcctgtaatc ccagcatttt gggaggccaa ggcaggcaga tcacctgagg tcaggagttc   3600

cagaccagcc tggccaacat ggtgaaatcc catctctaca aaaataaaac agttagctgg   3660

gcatgatggc gggtgcctgt aatcccagct actcgggagg ctgaggcagg atagtcgctt   3720

gaacccagga ggtggaggtt gcaatgagcc aagatcatgc cactgcactc cagcctggac   3780

gacagagtga gactccatca caagaaaaaa agaactttgt caacctctgt cttagggcgc   3840

cttgtcacag gcttcgggtc agacggattc aaccttgcat cagccatttg ttagccaggt   3900

cactctgttc tttgtctgta aatgagattg atcgttgttc ccactgagag tgtcagctcc   3960

ttcccgtaga gcaggcatga tgattgtact cacctctgac accattgtga gtgccacatt   4020

ccttcccacg tccttgtcac tgtaagagat gcccacctga gcaccaaccc caggttatct   4080

tcccctttgt cttccagccc cccagaaaca gctacgactc aacctaccca atcatttcat   4140

catcagattg ccactgtctc tagttcaggt ctcttgggac tggcactcag aaatctcata   4200

ataaatcctc ttgaggcttc tcatacactc gtcttcttcc aatcttcttt ccctcaaaat   4260

ctcatatttt ggttccactt cacccaccgt cattctccat atcactccca ggagttaggc   4320

aaaaagcccc ttccgttctt ccgtatgtta aacttagaat cactctgttc cctgctctgc   4380

gtttctattt tttgtttttc ctccatttac tagtagctta acactttcta acagtgttct   4440

tattattgat acgtatctat ctcttccata agcttataag gtcacggata atacttctca   4500

ttgtagtacg taaatgacgt gggctagata tgagttgaat aaacagttat acctgtaaat   4560

tcttacagag tgaaaataaa ttgttatact ttacaatttg tttctctctt tagaccattt   4620

ccaggacttg tgattaataa ccgtgagtat tttgtgaagt gttttgtttt tgttttttcc   4680

tggggtctga cgtgtgtgcg tgtgagtgtg tatacatgct taacgtatat cacgttactt   4740

cacctatgtc agtaaccagg ccaaatactt gttttagccc tcagtaaaaa caccaggcac   4800

ttcctagttg taaaattatt caagcttctt aacttcctat cctcgatgca cttaatcata   4860

aaatggtaat aatagcaccg attttggggg agtcgttcca gtagatggaa agcatctgga   4920

acaggtgtca gcaagctcct gccgacgtgt atgcataaag ttttattgaa accaccatcg   4980

tgtccatttg tttatggcag aactgagaga tggcagcagc aagtgtgtgc ctgcaaaacc   5040

taaaatattt actaattggc tctgcaagaa aagagtttgc atccccctaa cctagaacag   5100

tgtctagcct ctagtatgtg tttagcctac agtatgtgct cagcgaatac aatctatatt   5160

tattactgct tttatgactg ttataattac tgtgcttgga tttcgttaca aagtaagtca   5220

caatgtgcct gcttctgtta gtatttcagc acagtgcctg gcacacatgg ggctctcaaa   5280

tattgctgag cgagtgaaca aatgtccttt caattcctta acgttgatgt cattttcaat   5340

agtattttga gccaaactta attttgcgag tgtgttttgt tttcttaact ttattattaa   5400

aaatgtataa aagtgaggcc aggcgtggtg gctcacgcct gtaatcccag cagtttggga   5460

ggctgaggca ggcggatcag ttgaggttgg gagttggaga ccagcccgtc caacatggtg   5520

aaagcctgtc tctactaaaa atacaaaaat cagctgggtg tggtggcgcg tgcctgtaat   5580

cccagctact caggaggctg aggcaggaga gttgcttgaa tcctagaggt ggaggttgca   5640

gtgagctgag atcgtgccat tgcactccag cctgggcaac aagagcaaaa ctctgtccca   5700

ataaataaat aaataaaatg ttctcttttg ttcctgttct tgtgcggtag tgtggtatag   5760

agttttatgg taattactgt gaattagtga ttctgaggga catatcagaa ctctgaggtt   5820

tgtttccttc tcatcttgag ggaaacagca aatgtatgtt aaaatgcttt tccaagggaa   5880

caacacatcc ttacattatt taaaccaatc tgcttcattt tcagagctgg ttgatcagag   5940

tgagtcagaa ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc   6000

cacagaagaa ataaaagaga ctgatggaag ctctcagatc aagcaagaac cagaccccac   6060

gtggtagacc tcttccctcc taggcttaaa gtatcagtgg ttgagaagag cttttcggac   6120

ctgttactac cccaagctgt gtaatatact tgtataacag aaataccttc tatacaaacc   6180

tttttttcta cttttagata gaaatgtcta ctttttcagc agttctgtga attaaagagc   6240

agagtgactg tgggtctgga atggctggtg tacttgggaa tgtactatca ggattttaca   6300

gcaatgctgg gaaatgacag ggaaaatgac aggaatgaat ctcaccagat tttttatgta   6360

ctcagcagag ccttgagtta cggtgtttat tttccaatca agtgaagata tctcctactt   6420

ctcctactgg aacatctcag cttctgcagt gaagaaaaat tcctgtgata gttcagttct   6480

ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat cctttgttca cggctctcct   6540

taatgactga gtgaacagtt cctatctgta tatttgacta aaccttttcc taagctatct   6600

ctcatggttc ctatgttttt ttatcataat taaaagcaaa accatctgga tcacctaaca   6660

gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa tacagagaga acctcttcca   6720

cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga agttgaagat cgggttgagg   6780

attggggcta gctcgatgac actaaggccc caacatcgcg ggacctgctg tggcgcggat   6840

tcttaggaac gctgttctag ccggccccct ctccaggggt cgccgtggcc ggcattattt   6900

cctagttctt cttgtaaccc tgaggtgcca gcgcggggag tgaggagggg tcagggggct   6960

aaggatgcaa cctctgacgt tctgcgcctt cctaggagag tcttacatgt gttgagattt   7020

cacaagcaat gcgagttgta aaataccagc tctacaagaa gctaggctct gtgacggcat   7080

agttttcagt agctttatca caatattcac aatggagaat tatatgacat ggtagcagaa   7140

ataggccctt ttatgtgttg cttctatttt acctcaaatt gtagatatag ggtaatcaat   7200

aaaatccatc catgcctttc acacactaag t                                  7231


<210>  5143
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  5143

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala 



<210>  5144
<211>  4295
<212>  DNA
<213>  Homo sapiens

<400>  5144
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1080

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1140

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1200

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1260

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1320

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1380

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1440

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1500

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1560

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1620

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1680

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1740

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1800

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1860

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1920

catatcctgt gtttgaatca aacccggagt tcttgtatgt ggaaggcttg ccagagggga   1980

ttcccttccg aagccctacc tggtttggaa ttccacgact tgaaaggatc gtccgcggga   2040

gtaataaaat caagttcgtt gttaaaaaac ctgaactagt tatttcctac ttgcctcctg   2100

ggatggctag taaaataaac actaaagctt tgcagtcccc caaaagacca cgaagtcctg   2160

ggagtaattc aaaggttcct gaaattgagg tcaccgtgga aggccctaat aacaacaatc   2220

ctcaaacctc agctgttcga accccgaccc agactaacgg ttctaacgtt cccttcaagc   2280

cacgagggag agagttttcc tttgaggcct ggaatgccaa aatcacggac ctaaaacaga   2340

aagttgaaaa tctcttcaat gagaaatgtg gggaagctct tggccttaaa caagctgtga   2400

aggtgccgtt cgcgttattt gagtctttcc cggaagactt ttatgtggaa ggcttacctg   2460

agggtgtgcc attccgaaga ccatcgactt ttggcattcc gaggctggag aagatactca   2520

gaaacaaagc caaaattaag ttcatcatta aaaagcccga aatgtttgag acggcgatta   2580

aggagagcac ctcctctaag agccctccca gaaaaataaa ttcatcaccc aatgttaata   2640

ctactgcatc aggtgttgaa gaccttaaca tcattcaggt gacaattcca gatgatgata   2700

atgaaagact ctcgaaagtt gaaaaagcta gacagctaag agaacaagtg aatgacctct   2760

ttagtcggaa atttggtgaa gctattggta tgggttttcc tgtgaaagtt ccctacagga   2820

aaatcacaat taaccctggc tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca   2880

aagcccccag ctacctggaa atcagctcca tgagaaggat cttagactct gccgagttta   2940

tcaaattcac ggtcattaga ccatttccag gacttgtgat taataaccag ctggttgatc   3000

agagtgagtc agaaggcccc gtgatacaag aatcagctga accaagccag ttggaagttc   3060

cagccacaga agaaataaaa gagactgatg gaagctctca gatcaagcaa gaaccagacc   3120

ccacgtggta gacctcttcc ctcctaggct taaagtatca gtggttgaga agagcttttc   3180

ggacctgtta ctaccccaag ctgtgtaata tacttgtata acagaaatac cttctataca   3240

aacctttttt tctactttta gatagaaatg tctacttttt cagcagttct gtgaattaaa   3300

gagcagagtg actgtgggtc tggaatggct ggtgtacttg ggaatgtact atcaggattt   3360

tacagcaatg ctgggaaatg acagggaaaa tgacaggaat gaatctcacc agatttttta   3420

tgtactcagc agagccttga gttacggtgt ttattttcca atcaagtgaa gatatctcct   3480

acttctccta ctggaacatc tcagcttctg cagtgaagaa aaattcctgt gatagttcag   3540

ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa tgatcctttg ttcacggctc   3600

tccttaatga ctgagtgaac agttcctatc tgtatatttg actaaacctt ttcctaagct   3660

atctctcatg gttcctatgt ttttttatca taattaaaag caaaaccatc tggatcacct   3720

aacagtcaga ggtcagtatc tcagcgtgtg aattatagag gaaatacaga gagaacctct   3780

tccactttta cttttcgtcc aaataaaatg catggtgtac cagaagttga agatcgggtt   3840

gaggattggg gctagctcga tgacactaag gccccaacat cgcgggacct gctgtggcgc   3900

ggattcttag gaacgctgtt ctagccggcc ccctctccag gggtcgccgt ggccggcatt   3960

atttcctagt tcttcttgta accctgaggt gccagcgcgg ggagtgagga ggggtcaggg   4020

ggctaaggat gcaacctctg acgttctgcg ccttcctagg agagtcttac atgtgttgag   4080

atttcacaag caatgcgagt tgtaaaatac cagctctaca agaagctagg ctctgtgacg   4140

gcatagtttt cagtagcttt atcacaatat tcacaatgga gaattatatg acatggtagc   4200

agaaataggc ccttttatgt gttgcttcta ttttacctca aattgtagat atagggtaat   4260

caataaaatc catccatgcc tttcacacac taagt                              4295


<210>  5145
<211>  957
<212>  PRT
<213>  Homo sapiens

<400>  5145

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
                565                 570                 575


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
            580                 585                 590


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
        595                 600                 605


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
    610                 615                 620


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
625                 630                 635                 640


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
                645                 650                 655


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
            660                 665                 670


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
        675                 680                 685


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
    690                 695                 700


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
705                 710                 715                 720


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
                725                 730                 735


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
            740                 745                 750


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
        755                 760                 765


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
    770                 775                 780


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
785                 790                 795                 800


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
                805                 810                 815


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
            820                 825                 830


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
        835                 840                 845


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
    850                 855                 860


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
865                 870                 875                 880


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
                885                 890                 895


Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu 
            900                 905                 910


Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu 
        915                 920                 925


Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp 
    930                 935                 940


Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950                 955


<210>  5146
<211>  5038
<212>  DNA
<213>  Homo sapiens

<400>  5146
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   1980

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   2040

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2100

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2160

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2220

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2280

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2340

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2400

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2460

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2520

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2580

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2640

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2700

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2760

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2820

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2880

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   2940

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   3000

cggtcattag accatttcca ggacttgtga ttaataacca gctggttgat cagagtgagt   3060

cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt ccagccacag   3120

aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac cccacgtggt   3180

agacctcttc cctcctaggg taaatcagct tctgtgtcag ggatgctgtg tggtgtccat   3240

ctgaaccccc tgcatacgcg tagctaatgt gatctcccca ctttcacata agatggtggc   3300

cctgccttca gggaatgtgg gagccaggtg ggagccttcc cggatattta agctagaaga   3360

ttctacaggg agattctcct tggatcaata tatgtctctc agtcaaagat gtaaaagcac   3420

ttttgcctta aaaagaatgt tctgtttcta aatagagtca acgttgtcct cctcattgga   3480

attcactatg agtcagaatc attagactga cttttttttt tccatagtaa tagtattttg   3540

cagagtctca cagagctgca gatcttttgt tcatcttgca gagttaacaa gtctgatcct   3600

gttagtccag atttcttaaa tttggccaag ttataatagg agcagtagct tgagacccga   3660

agtcaggaaa ctttgacaat ggattttttt ttttaatcca gagacttgta ctggaatttg   3720

ccttaccctg tcagctcatg gacttaaggt ttcatcccgc tttatgagtg cttctgaatc   3780

caagtcattg ttacctgaat ttgcaaatta agttgtgata ttcgtgactg ttaaattcct   3840

gtaattagat taacctcttt gcttgcttgt ttgttttctc tcctatttta gcttaaagta   3900

tcagtggttg agaagagctt ttcggacctg ttactacccc aagctgtgta atatacttgt   3960

ataacagaaa taccttctat acaaaccttt ttttctactt ttagatagaa atgtctactt   4020

tttcagcagt tctgtgaatt aaagagcaga gtgactgtgg gtctggaatg gctggtgtac   4080

ttgggaatgt actatcagga ttttacagca atgctgggaa atgacaggga aaatgacagg   4140

aatgaatctc accagatttt ttatgtactc agcagagcct tgagttacgg tgtttatttt   4200

ccaatcaagt gaagatatct cctacttctc ctactggaac atctcagctt ctgcagtgaa   4260

gaaaaattcc tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa aaaatcattt   4320

aaatgatcct ttgttcacgg ctctccttaa tgactgagtg aacagttcct atctgtatat   4380

ttgactaaac cttttcctaa gctatctctc atggttccta tgttttttta tcataattaa   4440

aagcaaaacc atctggatca cctaacagtc agaggtcagt atctcagcgt gtgaattata   4500

gaggaaatac agagagaacc tcttccactt ttacttttcg tccaaataaa atgcatggtg   4560

taccagaagt tgaagatcgg gttgaggatt ggggctagct cgatgacact aaggccccaa   4620

catcgcggga cctgctgtgg cgcggattct taggaacgct gttctagccg gccccctctc   4680

caggggtcgc cgtggccggc attatttcct agttcttctt gtaaccctga ggtgccagcg   4740

cggggagtga ggaggggtca gggggctaag gatgcaacct ctgacgttct gcgccttcct   4800

aggagagtct tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa taccagctct   4860

acaagaagct aggctctgtg acggcatagt tttcagtagc tttatcacaa tattcacaat   4920

ggagaattat atgacatggt agcagaaata ggccctttta tgtgttgctt ctattttacc   4980

tcaaattgta gatatagggt aatcaataaa atccatccat gcctttcaca cactaagt     5038


<210>  5147
<211>  974
<212>  PRT
<213>  Homo sapiens

<400>  5147

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala 
545                 550                 555                 560


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
                565                 570                 575


Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile 
            580                 585                 590


Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile 
        595                 600                 605


Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu 
    610                 615                 620


Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys 
625                 630                 635                 640


Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys 
                645                 650                 655


Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro 
            660                 665                 670


Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val 
        675                 680                 685


Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala 
    690                 695                 700


Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys 
705                 710                 715                 720


Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala 
                725                 730                 735


Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu 
            740                 745                 750


Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu 
        755                 760                 765


Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro 
    770                 775                 780


Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro 
785                 790                 795                 800


Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly 
                805                 810                 815


Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn 
            820                 825                 830


Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val 
        835                 840                 845


Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe 
    850                 855                 860


Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val 
865                 870                 875                 880


Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr 
                885                 890                 895


Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile 
            900                 905                 910


Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln 
        915                 920                 925


Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala 
    930                 935                 940


Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr 
945                 950                 955                 960


Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
                965                 970


<210>  5148
<211>  4905
<212>  DNA
<213>  Homo sapiens

<400>  5148
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag    960

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1020

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1080

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1140

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1200

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1260

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1320

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1380

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1440

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1500

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1560

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1620

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1680

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1740

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1800

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1860

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1920

aatcaaaccc ggagttcttg aaaggatcgt ccgcgggagt aataaaatca agttcgttgt   1980

taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta aaataaacac   2040

taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa aggttcctga   2100

aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag ctgttcgaac   2160

cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag agttttcctt   2220

tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc tcttcaatga   2280

gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg cgttatttga   2340

gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat tccgaagacc   2400

atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca aaattaagtt   2460

catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct cctctaagag   2520

ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag gtgttgaaga   2580

ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct cgaaagttga   2640

aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat ttggtgaagc   2700

tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta accctggctg   2760

tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct acctggaaat   2820

cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg tcattagacc   2880

atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag aaggccccgt   2940

gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag aaataaaaga   3000

gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga cctcttccct   3060

cctagggtaa atcagcttct gtgtcaggga tgctgtgtgg tgtccatctg aaccccctgc   3120

atacgcgtag ctaatgtgat ctccccactt tcacataaga tggtggccct gccttcaggg   3180

aatgtgggag ccaggtggga gccttcccgg atatttaagc tagaagattc tacagggaga   3240

ttctccttgg atcaatatat gtctctcagt caaagatgta aaagcacttt tgccttaaaa   3300

agaatgttct gtttctaaat agagtcaacg ttgtcctcct cattggaatt cactatgagt   3360

cagaatcatt agactgactt ttttttttcc atagtaatag tattttgcag agtctcacag   3420

agctgcagat cttttgttca tcttgcagag ttaacaagtc tgatcctgtt agtccagatt   3480

tcttaaattt ggccaagtta taataggagc agtagcttga gacccgaagt caggaaactt   3540

tgacaatgga tttttttttt taatccagag acttgtactg gaatttgcct taccctgtca   3600

gctcatggac ttaaggtttc atcccgcttt atgagtgctt ctgaatccaa gtcattgtta   3660

cctgaatttg caaattaagt tgtgatattc gtgactgtta aattcctgta attagattaa   3720

cctctttgct tgcttgtttg ttttctctcc tattttagct taaagtatca gtggttgaga   3780

agagcttttc ggacctgtta ctaccccaag ctgtgtaata tacttgtata acagaaatac   3840

cttctataca aacctttttt tctactttta gatagaaatg tctacttttt cagcagttct   3900

gtgaattaaa gagcagagtg actgtgggtc tggaatggct ggtgtacttg ggaatgtact   3960

atcaggattt tacagcaatg ctgggaaatg acagggaaaa tgacaggaat gaatctcacc   4020

agatttttta tgtactcagc agagccttga gttacggtgt ttattttcca atcaagtgaa   4080

gatatctcct acttctccta ctggaacatc tcagcttctg cagtgaagaa aaattcctgt   4140

gatagttcag ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa tgatcctttg   4200

ttcacggctc tccttaatga ctgagtgaac agttcctatc tgtatatttg actaaacctt   4260

ttcctaagct atctctcatg gttcctatgt ttttttatca taattaaaag caaaaccatc   4320

tggatcacct aacagtcaga ggtcagtatc tcagcgtgtg aattatagag gaaatacaga   4380

gagaacctct tccactttta cttttcgtcc aaataaaatg catggtgtac cagaagttga   4440

agatcgggtt gaggattggg gctagctcga tgacactaag gccccaacat cgcgggacct   4500

gctgtggcgc ggattcttag gaacgctgtt ctagccggcc ccctctccag gggtcgccgt   4560

ggccggcatt atttcctagt tcttcttgta accctgaggt gccagcgcgg ggagtgagga   4620

ggggtcaggg ggctaaggat gcaacctctg acgttctgcg ccttcctagg agagtcttac   4680

atgtgttgag atttcacaag caatgcgagt tgtaaaatac cagctctaca agaagctagg   4740

ctctgtgacg gcatagtttt cagtagcttt atcacaatat tcacaatgga gaattatatg   4800

acatggtagc agaaataggc ccttttatgt gttgcttcta ttttacctca aattgtagat   4860

atagggtaat caataaaatc catccatgcc tttcacacac taagt                   4905


<210>  5149
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  5149

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys 
                565                 570                 575


Asn Leu Asn 



<210>  5150
<211>  3728
<212>  DNA
<213>  Homo sapiens

<400>  5150
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag    960

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1020

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1080

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1140

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1200

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1260

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1320

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1380

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1440

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1500

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1560

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1620

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1680

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1740

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1800

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1860

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1920

aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc   1980

ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt   2040

tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa   2100

taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg   2160

ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg   2220

ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga gggagagagt   2280

tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct   2340

tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt   2400

tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc   2460

gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa   2520

ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct   2580

ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg   2640

ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga   2700

aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg   2760

gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc   2820

ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc   2880

tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca   2940

ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt gagtcagaag   3000

gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc acagaagaaa   3060

taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg tggtagacct   3120

cttccctcct aggcaaaacc atctggatca cctaacagtc agaggtcagt atctcagcgt   3180

gtgaattata gaggaaatac agagagaacc tcttccactt ttacttttcg tccaaataaa   3240

atgcatggtg taccagaagt tgaagatcgg gttgaggatt ggggctagct cgatgacact   3300

aaggccccaa catcgcggga cctgctgtgg cgcggattct taggaacgct gttctagccg   3360

gccccctctc caggggtcgc cgtggccggc attatttcct agttcttctt gtaaccctga   3420

ggtgccagcg cggggagtga ggaggggtca gggggctaag gatgcaacct ctgacgttct   3480

gcgccttcct aggagagtct tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa   3540

taccagctct acaagaagct aggctctgtg acggcatagt tttcagtagc tttatcacaa   3600

tattcacaat ggagaattat atgacatggt agcagaaata ggccctttta tgtgttgctt   3660

ctattttacc tcaaattgta gatatagggt aatcaataaa atccatccat gcctttcaca   3720

cactaagt                                                            3728


<210>  5151
<211>  952
<212>  PRT
<213>  Homo sapiens

<400>  5151

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr 
                565                 570                 575


Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys 
            580                 585                 590


Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro 
        595                 600                 605


Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys 
    610                 615                 620


Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val 
625                 630                 635                 640


Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg 
                645                 650                 655


Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly 
            660                 665                 670


Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys 
        675                 680                 685


Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly 
    690                 695                 700


Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro 
705                 710                 715                 720


Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg 
                725                 730                 735


Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys 
            740                 745                 750


Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala 
        755                 760                 765


Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser 
    770                 775                 780


Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile 
785                 790                 795                 800


Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val 
                805                 810                 815


Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg 
            820                 825                 830


Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr 
        835                 840                 845


Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro 
    850                 855                 860


Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met 
865                 870                 875                 880


Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
                885                 890                 895


Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu 
            900                 905                 910


Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu 
        915                 920                 925


Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile 
    930                 935                 940


Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  5152
<211>  4280
<212>  DNA
<213>  Homo sapiens

<400>  5152
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag    960

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1020

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1080

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1140

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1200

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1260

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1320

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1380

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1440

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1500

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1560

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1620

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1680

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1740

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1800

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1860

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1920

aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc   1980

ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt   2040

tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa   2100

taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg   2160

ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg   2220

ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga gggagagagt   2280

tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct   2340

tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt   2400

tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc   2460

gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa   2520

ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct   2580

ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg   2640

ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga   2700

aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg   2760

gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc   2820

ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc   2880

tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca   2940

ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt gagtcagaag   3000

gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc acagaagaaa   3060

taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg tggtagacct   3120

cttccctcct aggcttaaag tatcagtggt tgagaagagc ttttcggacc tgttactacc   3180

ccaagctgtg taatatactt gtataacaga aataccttct atacaaacct ttttttctac   3240

ttttagatag aaatgtctac tttttcagca gttctgtgaa ttaaagagca gagtgactgt   3300

gggtctggaa tggctggtgt acttgggaat gtactatcag gattttacag caatgctggg   3360

aaatgacagg gaaaatgaca ggaatgaatc tcaccagatt ttttatgtac tcagcagagc   3420

cttgagttac ggtgtttatt ttccaatcaa gtgaagatat ctcctacttc tcctactgga   3480

acatctcagc ttctgcagtg aagaaaaatt cctgtgatag ttcagttctt tagtttttct   3540

atttgaaaaa aaaaaatcat ttaaatgatc ctttgttcac ggctctcctt aatgactgag   3600

tgaacagttc ctatctgtat atttgactaa accttttcct aagctatctc tcatggttcc   3660

tatgtttttt tatcataatt aaaagcaaaa ccatctggat cacctaacag tcagaggtca   3720

gtatctcagc gtgtgaatta tagaggaaat acagagagaa cctcttccac ttttactttt   3780

cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc gggttgagga ttggggctag   3840

ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg   3900

ctgttctagc cggccccctc tccaggggtc gccgtggccg gcattatttc ctagttcttc   3960

ttgtaaccct gaggtgccag cgcggggagt gaggaggggt cagggggcta aggatgcaac   4020

ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg ttgagatttc acaagcaatg   4080

cgagttgtaa aataccagct ctacaagaag ctaggctctg tgacggcata gttttcagta   4140

gctttatcac aatattcaca atggagaatt atatgacatg gtagcagaaa taggcccttt   4200

tatgtgttgc ttctatttta cctcaaattg tagatatagg gtaatcaata aaatccatcc   4260

atgcctttca cacactaagt                                               4280


<210>  5153
<211>  952
<212>  PRT
<213>  Homo sapiens

<400>  5153

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr 
                565                 570                 575


Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys 
            580                 585                 590


Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro 
        595                 600                 605


Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys 
    610                 615                 620


Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val 
625                 630                 635                 640


Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg 
                645                 650                 655


Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly 
            660                 665                 670


Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys 
        675                 680                 685


Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly 
    690                 695                 700


Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro 
705                 710                 715                 720


Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg 
                725                 730                 735


Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys 
            740                 745                 750


Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala 
        755                 760                 765


Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser 
    770                 775                 780


Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile 
785                 790                 795                 800


Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val 
                805                 810                 815


Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg 
            820                 825                 830


Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr 
        835                 840                 845


Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro 
    850                 855                 860


Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met 
865                 870                 875                 880


Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
                885                 890                 895


Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu 
            900                 905                 910


Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu 
        915                 920                 925


Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile 
    930                 935                 940


Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  5154
<211>  6974
<212>  DNA
<213>  Homo sapiens

<400>  5154
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag    960

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1020

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1080

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1140

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1200

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1260

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1320

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1380

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1440

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1500

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1560

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1620

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1680

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1740

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1800

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1860

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1920

aatcaaaccc ggagttcttg aaaggatcgt ccgcgggagt aataaaatca agttcgttgt   1980

taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta aaataaacac   2040

taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa aggttcctga   2100

aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag ctgttcgaac   2160

cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag agttttcctt   2220

tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc tcttcaatga   2280

gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg cgttatttga   2340

gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat tccgaagacc   2400

atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca aaattaagtt   2460

catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct cctctaagag   2520

ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag gtgttgaaga   2580

ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct cgaaagttga   2640

aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat ttggtgaagc   2700

tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta accctggctg   2760

tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct acctggaaat   2820

cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg tcattaggta   2880

agtgagagtt tcctgcttag tcacaggagc gaatctggag ctcatgaggc tgactcttct   2940

aaaatgcagc cacaggtagt catcgaatcc ggcttcctat gctgtgcaat caacaaatca   3000

aaataacttg tgtcatcatt agaatgtcag atgtgcttct acgaactaag ctgactcttt   3060

taattctttg gcaaagggtt ggcaaactag gactgtttgc caaattcagg ctgcctccta   3120

tttttagagt cttcctgaaa cacagctaca cccgtattat ccatggctgc tttcctgtca   3180

cagtgagtaa gtagctggga ctgagaaggc atggcctcca aagtctaaaa tatttactct   3240

ctagcacttt gtagaaaaac cttagctagg cacagtggct aacgcctgta atcccagcat   3300

tttgggaggc caaggcaggc agatcacctg aggtcaggag ttccagacca gcctggccaa   3360

catggtgaaa tcccatctct acaaaaataa aacagttagc tgggcatgat ggcgggtgcc   3420

tgtaatccca gctactcggg aggctgaggc aggatagtcg cttgaaccca ggaggtggag   3480

gttgcaatga gccaagatca tgccactgca ctccagcctg gacgacagag tgagactcca   3540

tcacaagaaa aaaagaactt tgtcaacctc tgtcttaggg cgccttgtca caggcttcgg   3600

gtcagacgga ttcaaccttg catcagccat ttgttagcca ggtcactctg ttctttgtct   3660

gtaaatgaga ttgatcgttg ttcccactga gagtgtcagc tccttcccgt agagcaggca   3720

tgatgattgt actcacctct gacaccattg tgagtgccac attccttccc acgtccttgt   3780

cactgtaaga gatgcccacc tgagcaccaa ccccaggtta tcttcccctt tgtcttccag   3840

ccccccagaa acagctacga ctcaacctac ccaatcattt catcatcaga ttgccactgt   3900

ctctagttca ggtctcttgg gactggcact cagaaatctc ataataaatc ctcttgaggc   3960

ttctcataca ctcgtcttct tccaatcttc tttccctcaa aatctcatat tttggttcca   4020

cttcacccac cgtcattctc catatcactc ccaggagtta ggcaaaaagc cccttccgtt   4080

cttccgtatg ttaaacttag aatcactctg ttccctgctc tgcgtttcta ttttttgttt   4140

ttcctccatt tactagtagc ttaacacttt ctaacagtgt tcttattatt gatacgtatc   4200

tatctcttcc ataagcttat aaggtcacgg ataatacttc tcattgtagt acgtaaatga   4260

cgtgggctag atatgagttg aataaacagt tatacctgta aattcttaca gagtgaaaat   4320

aaattgttat actttacaat ttgtttctct ctttagacca tttccaggac ttgtgattaa   4380

taaccgtgag tattttgtga agtgttttgt ttttgttttt tcctggggtc tgacgtgtgt   4440

gcgtgtgagt gtgtatacat gcttaacgta tatcacgtta cttcacctat gtcagtaacc   4500

aggccaaata cttgttttag ccctcagtaa aaacaccagg cacttcctag ttgtaaaatt   4560

attcaagctt cttaacttcc tatcctcgat gcacttaatc ataaaatggt aataatagca   4620

ccgattttgg gggagtcgtt ccagtagatg gaaagcatct ggaacaggtg tcagcaagct   4680

cctgccgacg tgtatgcata aagttttatt gaaaccacca tcgtgtccat ttgtttatgg   4740

cagaactgag agatggcagc agcaagtgtg tgcctgcaaa acctaaaata tttactaatt   4800

ggctctgcaa gaaaagagtt tgcatccccc taacctagaa cagtgtctag cctctagtat   4860

gtgtttagcc tacagtatgt gctcagcgaa tacaatctat atttattact gcttttatga   4920

ctgttataat tactgtgctt ggatttcgtt acaaagtaag tcacaatgtg cctgcttctg   4980

ttagtatttc agcacagtgc ctggcacaca tggggctctc aaatattgct gagcgagtga   5040

acaaatgtcc tttcaattcc ttaacgttga tgtcattttc aatagtattt tgagccaaac   5100

ttaattttgc gagtgtgttt tgttttctta actttattat taaaaatgta taaaagtgag   5160

gccaggcgtg gtggctcacg cctgtaatcc cagcagtttg ggaggctgag gcaggcggat   5220

cagttgaggt tgggagttgg agaccagccc gtccaacatg gtgaaagcct gtctctacta   5280

aaaatacaaa aatcagctgg gtgtggtggc gcgtgcctgt aatcccagct actcaggagg   5340

ctgaggcagg agagttgctt gaatcctaga ggtggaggtt gcagtgagct gagatcgtgc   5400

cattgcactc cagcctgggc aacaagagca aaactctgtc ccaataaata aataaataaa   5460

atgttctctt ttgttcctgt tcttgtgcgg tagtgtggta tagagtttta tggtaattac   5520

tgtgaattag tgattctgag ggacatatca gaactctgag gtttgtttcc ttctcatctt   5580

gagggaaaca gcaaatgtat gttaaaatgc ttttccaagg gaacaacaca tccttacatt   5640

atttaaacca atctgcttca ttttcagagc tggttgatca gagtgagtca gaaggccccg   5700

tgatacaaga atcagctgaa ccaagccagt tggaagttcc agccacagaa gaaataaaag   5760

agactgatgg aagctctcag atcaagcaag aaccagaccc cacgtggtag acctcttccc   5820

tcctaggctt aaagtatcag tggttgagaa gagcttttcg gacctgttac taccccaagc   5880

tgtgtaatat acttgtataa cagaaatacc ttctatacaa accttttttt ctacttttag   5940

atagaaatgt ctactttttc agcagttctg tgaattaaag agcagagtga ctgtgggtct   6000

ggaatggctg gtgtacttgg gaatgtacta tcaggatttt acagcaatgc tgggaaatga   6060

cagggaaaat gacaggaatg aatctcacca gattttttat gtactcagca gagccttgag   6120

ttacggtgtt tattttccaa tcaagtgaag atatctccta cttctcctac tggaacatct   6180

cagcttctgc agtgaagaaa aattcctgtg atagttcagt tctttagttt ttctatttga   6240

aaaaaaaaaa tcatttaaat gatcctttgt tcacggctct ccttaatgac tgagtgaaca   6300

gttcctatct gtatatttga ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt   6360

tttttatcat aattaaaagc aaaaccatct ggatcaccta acagtcagag gtcagtatct   6420

cagcgtgtga attatagagg aaatacagag agaacctctt ccacttttac ttttcgtcca   6480

aataaaatgc atggtgtacc agaagttgaa gatcgggttg aggattgggg ctagctcgat   6540

gacactaagg ccccaacatc gcgggacctg ctgtggcgcg gattcttagg aacgctgttc   6600

tagccggccc cctctccagg ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa   6660

ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg gctaaggatg caacctctga   6720

cgttctgcgc cttcctagga gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt   6780

gtaaaatacc agctctacaa gaagctaggc tctgtgacgg catagttttc agtagcttta   6840

tcacaatatt cacaatggag aattatatga catggtagca gaaataggcc cttttatgtg   6900

ttgcttctat tttacctcaa attgtagata tagggtaatc aataaaatcc atccatgcct   6960

ttcacacact aagt                                                     6974


<210>  5155
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  5155

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys 
                565                 570                 575


Asn Leu Asn 



<210>  5156
<211>  4002
<212>  DNA
<213>  Homo sapiens

<400>  5156
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1080

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1140

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1200

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1260

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1320

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1380

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1440

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1500

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1560

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1620

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1680

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1740

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1800

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1860

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   1920

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   1980

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2040

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2100

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2160

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2220

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2280

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2340

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2400

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2460

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2520

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2580

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2640

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2700

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2760

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2820

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   2880

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   2940

cggtcattag accatttcca ggacttgtga ttaataacca gctggttgat cagagtgagt   3000

cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt ccagccacag   3060

aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac cccacgtggt   3120

agacctcttc cctcctagga gccttgagtt acggtgttta ttttccaatc aagtgaagat   3180

atctcctact tctcctactg gaacatctca gcttctgcag tgaagaaaaa ttcctgtgat   3240

agttcagttc tttagttttt ctatttgaaa aaaaaaaatc atttaaatga tcctttgttc   3300

acggctctcc ttaatgactg agtgaacagt tcctatctgt atatttgact aaaccttttc   3360

ctaagctatc tctcatggtt cctatgtttt tttatcataa ttaaaagcaa aaccatctgg   3420

atcacctaac agtcagaggt cagtatctca gcgtgtgaat tatagaggaa atacagagag   3480

aacctcttcc acttttactt ttcgtccaaa taaaatgcat ggtgtaccag aagttgaaga   3540

tcgggttgag gattggggct agctcgatga cactaaggcc ccaacatcgc gggacctgct   3600

gtggcgcgga ttcttaggaa cgctgttcta gccggccccc tctccagggg tcgccgtggc   3660

cggcattatt tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga gtgaggaggg   3720

gtcagggggc taaggatgca acctctgacg ttctgcgcct tcctaggaga gtcttacatg   3780

tgttgagatt tcacaagcaa tgcgagttgt aaaataccag ctctacaaga agctaggctc   3840

tgtgacggca tagttttcag tagctttatc acaatattca caatggagaa ttatatgaca   3900

tggtagcaga aataggccct tttatgtgtt gcttctattt tacctcaaat tgtagatata   3960

gggtaatcaa taaaatccat ccatgccttt cacacactaa gt                      4002


<210>  5157
<211>  954
<212>  PRT
<213>  Homo sapiens

<400>  5157

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly 
    530                 535                 540


Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro 
545                 550                 555                 560


Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser 
                565                 570                 575


Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser 
            580                 585                 590


Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr 
        595                 600                 605


Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser 
    610                 615                 620


Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile 
625                 630                 635                 640


Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala 
                645                 650                 655


Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro 
            660                 665                 670


Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp 
        675                 680                 685


Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala 
    690                 695                 700


Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser 
705                 710                 715                 720


Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe 
                725                 730                 735


Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg 
            740                 745                 750


Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu 
        755                 760                 765


Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile 
    770                 775                 780


Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu 
785                 790                 795                 800


Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser 
                805                 810                 815


Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe 
            820                 825                 830


Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val 
        835                 840                 845


Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly 
    850                 855                 860


Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser 
865                 870                 875                 880


Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val 
                885                 890                 895


Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln 
            900                 905                 910


Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln 
        915                 920                 925


Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser 
    930                 935                 940


Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  5158
<211>  4900
<212>  DNA
<213>  Homo sapiens

<400>  5158
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag    960

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1020

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1080

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1140

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1200

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1260

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1320

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1380

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1440

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1500

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1560

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1620

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1680

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1740

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagctc   1800

aagctcttgg actcaccgag gcagtaaaag taccatatcc tgtgtttgaa tcaaacccgg   1860

agttcttgta tgtggaaggc ttgccagagg ggattccctt ccgaagccct acctggtttg   1920

gaattccacg acttgaaagg atcgtccgcg ggagtaataa aatcaagttc gttgttaaaa   1980

aacctgaact agttatttcc tacttgcctc ctgggatggc tagtaaaata aacactaaag   2040

ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa ttcaaaggtt cctgaaattg   2100

aggtcaccgt ggaaggccct aataacaaca atcctcaaac ctcagctgtt cgaaccccga   2160

cccagactaa cggttctaac gttcccttca agccacgagg gagagagttt tcctttgagg   2220

cctggaatgc caaaatcacg gacctaaaac agaaagttga aaatctcttc aatgagaaat   2280

gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc gttcgcgtta tttgagtctt   2340

tcccggaaga cttttatgtg gaaggcttac ctgagggtgt gccattccga agaccatcga   2400

cttttggcat tccgaggctg gagaagatac tcagaaacaa agccaaaatt aagttcatca   2460

ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag cacctcctct aagagccctc   2520

ccagaaaaat aaattcatca cccaatgtta atactactgc atcaggtgtt gaagacctta   2580

acatcattca ggtgacaatt ccagatgatg ataatgaaag actctcgaaa gttgaaaaag   2640

ctagacagct aagagaacaa gtgaatgacc tctttagtcg gaaatttggt gaagctattg   2700

gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac aattaaccct ggctgtgtgg   2760

tggttgatgg catgcccccg ggggtgtcct tcaaagcccc cagctacctg gaaatcagct   2820

ccatgagaag gatcttagac tctgccgagt ttatcaaatt cacggtcatt agaccatttc   2880

caggacttgt gattaataac cagctggttg atcagagtga gtcagaaggc cccgtgatac   2940

aagaatcagc tgaaccaagc cagttggaag ttccagccac agaagaaata aaagagactg   3000

atggaagctc tcagatcaag caagaaccag accccacgtg gtagacctct tccctcctag   3060

ggtaaatcag cttctgtgtc agggatgctg tgtggtgtcc atctgaaccc cctgcatacg   3120

cgtagctaat gtgatctccc cactttcaca taagatggtg gccctgcctt cagggaatgt   3180

gggagccagg tgggagcctt cccggatatt taagctagaa gattctacag ggagattctc   3240

cttggatcaa tatatgtctc tcagtcaaag atgtaaaagc acttttgcct taaaaagaat   3300

gttctgtttc taaatagagt caacgttgtc ctcctcattg gaattcacta tgagtcagaa   3360

tcattagact gacttttttt tttccatagt aatagtattt tgcagagtct cacagagctg   3420

cagatctttt gttcatcttg cagagttaac aagtctgatc ctgttagtcc agatttctta   3480

aatttggcca agttataata ggagcagtag cttgagaccc gaagtcagga aactttgaca   3540

atggattttt ttttttaatc cagagacttg tactggaatt tgccttaccc tgtcagctca   3600

tggacttaag gtttcatccc gctttatgag tgcttctgaa tccaagtcat tgttacctga   3660

atttgcaaat taagttgtga tattcgtgac tgttaaattc ctgtaattag attaacctct   3720

ttgcttgctt gtttgttttc tctcctattt tagcttaaag tatcagtggt tgagaagagc   3780

ttttcggacc tgttactacc ccaagctgtg taatatactt gtataacaga aataccttct   3840

atacaaacct ttttttctac ttttagatag aaatgtctac tttttcagca gttctgtgaa   3900

ttaaagagca gagtgactgt gggtctggaa tggctggtgt acttgggaat gtactatcag   3960

gattttacag caatgctggg aaatgacagg gaaaatgaca ggaatgaatc tcaccagatt   4020

ttttatgtac tcagcagagc cttgagttac ggtgtttatt ttccaatcaa gtgaagatat   4080

ctcctacttc tcctactgga acatctcagc ttctgcagtg aagaaaaatt cctgtgatag   4140

ttcagttctt tagtttttct atttgaaaaa aaaaaatcat ttaaatgatc ctttgttcac   4200

ggctctcctt aatgactgag tgaacagttc ctatctgtat atttgactaa accttttcct   4260

aagctatctc tcatggttcc tatgtttttt tatcataatt aaaagcaaaa ccatctggat   4320

cacctaacag tcagaggtca gtatctcagc gtgtgaatta tagaggaaat acagagagaa   4380

cctcttccac ttttactttt cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc   4440

gggttgagga ttggggctag ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt   4500

ggcgcggatt cttaggaacg ctgttctagc cggccccctc tccaggggtc gccgtggccg   4560

gcattatttc ctagttcttc ttgtaaccct gaggtgccag cgcggggagt gaggaggggt   4620

cagggggcta aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg   4680

ttgagatttc acaagcaatg cgagttgtaa aataccagct ctacaagaag ctaggctctg   4740

tgacggcata gttttcagta gctttatcac aatattcaca atggagaatt atatgacatg   4800

gtagcagaaa taggcccttt tatgtgttgc ttctatttta cctcaaattg tagatatagg   4860

gtaatcaata aaatccatcc atgcctttca cacactaagt                         4900


<210>  5159
<211>  928
<212>  PRT
<213>  Homo sapiens

<400>  5159

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro 
        515                 520                 525


Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu 
    530                 535                 540


Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu 
545                 550                 555                 560


Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro 
                565                 570                 575


Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn 
            580                 585                 590


Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn 
        595                 600                 605


Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn 
    610                 615                 620


Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser 
625                 630                 635                 640


Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp 
                645                 650                 655


Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn 
            660                 665                 670


Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro 
        675                 680                 685


Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu 
    690                 695                 700


Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg 
705                 710                 715                 720


Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys 
                725                 730                 735


Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys 
            740                 745                 750


Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala 
        755                 760                 765


Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp 
    770                 775                 780


Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu 
785                 790                 795                 800


Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met 
                805                 810                 815


Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly 
            820                 825                 830


Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro 
        835                 840                 845


Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu 
    850                 855                 860


Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn 
865                 870                 875                 880


Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu 
                885                 890                 895


Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys 
            900                 905                 910


Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
        915                 920                 925


<210>  5160
<211>  3918
<212>  DNA
<213>  Homo sapiens

<400>  5160
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1080

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1140

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1200

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1260

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1320

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1380

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1440

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1500

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1560

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1620

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1680

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1740

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1800

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1860

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1920

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   1980

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2040

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2100

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2160

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2220

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2280

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2340

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2400

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2460

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2520

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2580

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2640

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2700

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2760

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2820

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   2880

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   2940

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3000

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3060

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3120

ttcacggtca ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt   3180

gagtcagaag gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc   3240

acagaagaaa taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg   3300

tggtagacct cttccctcct aggcaaaacc atctggatca cctaacagtc agaggtcagt   3360

atctcagcgt gtgaattata gaggaaatac agagagaacc tcttccactt ttacttttcg   3420

tccaaataaa atgcatggtg taccagaagt tgaagatcgg gttgaggatt ggggctagct   3480

cgatgacact aaggccccaa catcgcggga cctgctgtgg cgcggattct taggaacgct   3540

gttctagccg gccccctctc caggggtcgc cgtggccggc attatttcct agttcttctt   3600

gtaaccctga ggtgccagcg cggggagtga ggaggggtca gggggctaag gatgcaacct   3660

ctgacgttct gcgccttcct aggagagtct tacatgtgtt gagatttcac aagcaatgcg   3720

agttgtaaaa taccagctct acaagaagct aggctctgtg acggcatagt tttcagtagc   3780

tttatcacaa tattcacaat ggagaattat atgacatggt agcagaaata ggccctttta   3840

tgtgttgctt ctattttacc tcaaattgta gatatagggt aatcaataaa atccatccat   3900

gcctttcaca cactaagt                                                 3918


<210>  5161
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  5161

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala 



<210>  5162
<211>  4123
<212>  DNA
<213>  Homo sapiens

<400>  5162
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040

taccatatcc tgtgtttgaa tcaaacccgg agttcttgaa aggatcgtcc gcgggagtaa   2100

taaaatcaag ttcgttgtta aaaaacctga actagttatt tcctacttgc ctcctgggat   2160

ggctagtaaa ataaacacta aagctttgca gtcccccaaa agaccacgaa gtcctgggag   2220

taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc cctaataaca acaatcctca   2280

aacctcagct gttcgaaccc cgacccagac taacggttct aacgttccct tcaagccacg   2340

agggagagag ttttcctttg aggcctggaa tgccaaaatc acggacctaa aacagaaagt   2400

tgaaaatctc ttcaatgaga aatgtgggga agctcttggc cttaaacaag ctgtgaaggt   2460

gccgttcgcg ttatttgagt ctttcccgga agacttttat gtggaaggct tacctgaggg   2520

tgtgccattc cgaagaccat cgacttttgg cattccgagg ctggagaaga tactcagaaa   2580

caaagccaaa attaagttca tcattaaaaa gcccgaaatg tttgagacgg cgattaagga   2640

gagcacctcc tctaagagcc ctcccagaaa aataaattca tcacccaatg ttaatactac   2700

tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca attccagatg atgataatga   2760

aagactctcg aaagttgaaa aagctagaca gctaagagaa caagtgaatg acctctttag   2820

tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg aaagttccct acaggaaaat   2880

cacaattaac cctggctgtg tggtggttga tggcatgccc ccgggggtgt ccttcaaagc   2940

ccccagctac ctggaaatca gctccatgag aaggatctta gactctgccg agtttatcaa   3000

attcacggtc attagaccat ttccaggact tgtgattaat aaccagctgg ttgatcagag   3060

tgagtcagaa ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc   3120

cacagaagaa ataaaagaga ctgatggaag ctctcagatc aagcaagaac cagaccccac   3180

gtggtagacc tcttccctcc taggcttaaa gtatcagtgg ttgagaagag cttttcggac   3240

ctgttactac cccaagctgt agccttgagt tacggtgttt attttccaat caagtgaaga   3300

tatctcctac ttctcctact ggaacatctc agcttctgca gtgaagaaaa attcctgtga   3360

tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat catttaaatg atcctttgtt   3420

cacggctctc cttaatgact gagtgaacag ttcctatctg tatatttgac taaacctttt   3480

cctaagctat ctctcatggt tcctatgttt ttttatcata attaaaagca aaaccatctg   3540

gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa ttatagagga aatacagaga   3600

gaacctcttc cacttttact tttcgtccaa ataaaatgca tggtgtacca gaagttgaag   3660

atcgggttga ggattggggc tagctcgatg acactaaggc cccaacatcg cgggacctgc   3720

tgtggcgcgg attcttagga acgctgttct agccggcccc ctctccaggg gtcgccgtgg   3780

ccggcattat ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg   3840

ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc ttcctaggag agtcttacat   3900

gtgttgagat ttcacaagca atgcgagttg taaaatacca gctctacaag aagctaggct   3960

ctgtgacggc atagttttca gtagctttat cacaatattc acaatggaga attatatgac   4020

atggtagcag aaataggccc ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat   4080

agggtaatca ataaaatcca tccatgcctt tcacacacta agt                     4123


<210>  5163
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  5163

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys 
        595                 600                 605


Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu 
    610                 615                 620


Asn 
625


<210>  5164
<211>  4052
<212>  DNA
<213>  Homo sapiens

<400>  5164
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag    960

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1020

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1080

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1140

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1200

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1260

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1320

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1380

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1440

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1500

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1560

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1620

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1680

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1740

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1800

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1860

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1920

aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc ttccgaagcc   1980

ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat aaaatcaagt   2040

tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg gctagtaaaa   2100

taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt aattcaaagg   2160

ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa acctcagctg   2220

ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga gggagagagt   2280

tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt gaaaatctct   2340

tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg ccgttcgcgt   2400

tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt gtgccattcc   2460

gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac aaagccaaaa   2520

ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag agcacctcct   2580

ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact gcatcaggtg   2640

ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa agactctcga   2700

aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt cggaaatttg   2760

gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc acaattaacc   2820

ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc cccagctacc   2880

tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa ttcacggtca   2940

ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt gagtcagaag   3000

gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc acagaagaaa   3060

taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg tggtagacct   3120

cttccctcct aggcttaaag tatcagtggt tgagaagagc ttttcggacc tgttactacc   3180

ccaagctgta gccttgagtt acggtgttta ttttccaatc aagtgaagat atctcctact   3240

tctcctactg gaacatctca gcttctgcag tgaagaaaaa ttcctgtgat agttcagttc   3300

tttagttttt ctatttgaaa aaaaaaaatc atttaaatga tcctttgttc acggctctcc   3360

ttaatgactg agtgaacagt tcctatctgt atatttgact aaaccttttc ctaagctatc   3420

tctcatggtt cctatgtttt tttatcataa ttaaaagcaa aaccatctgg atcacctaac   3480

agtcagaggt cagtatctca gcgtgtgaat tatagaggaa atacagagag aacctcttcc   3540

acttttactt ttcgtccaaa taaaatgcat ggtgtaccag aagttgaaga tcgggttgag   3600

gattggggct agctcgatga cactaaggcc ccaacatcgc gggacctgct gtggcgcgga   3660

ttcttaggaa cgctgttcta gccggccccc tctccagggg tcgccgtggc cggcattatt   3720

tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc   3780

taaggatgca acctctgacg ttctgcgcct tcctaggaga gtcttacatg tgttgagatt   3840

tcacaagcaa tgcgagttgt aaaataccag ctctacaaga agctaggctc tgtgacggca   3900

tagttttcag tagctttatc acaatattca caatggagaa ttatatgaca tggtagcaga   3960

aataggccct tttatgtgtt gcttctattt tacctcaaat tgtagatata gggtaatcaa   4020

taaaatccat ccatgccttt cacacactaa gt                                 4052


<210>  5165
<211>  952
<212>  PRT
<213>  Homo sapiens

<400>  5165

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr 
                565                 570                 575


Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys 
            580                 585                 590


Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro 
        595                 600                 605


Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys 
    610                 615                 620


Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val 
625                 630                 635                 640


Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg 
                645                 650                 655


Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly 
            660                 665                 670


Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys 
        675                 680                 685


Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly 
    690                 695                 700


Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro 
705                 710                 715                 720


Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg 
                725                 730                 735


Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys 
            740                 745                 750


Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala 
        755                 760                 765


Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser 
    770                 775                 780


Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile 
785                 790                 795                 800


Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val 
                805                 810                 815


Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg 
            820                 825                 830


Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr 
        835                 840                 845


Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro 
    850                 855                 860


Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met 
865                 870                 875                 880


Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
                885                 890                 895


Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu 
            900                 905                 910


Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu 
        915                 920                 925


Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile 
    930                 935                 940


Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  5166
<211>  4975
<212>  DNA
<213>  Homo sapiens

<400>  5166
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agctcaagct cttggactca ccgaggcagt aaaagtacca tatcctgtgt   1920

ttgaatcaaa cccggagttc ttgtatgtgg aaggcttgcc agaggggatt cccttccgaa   1980

gccctacctg gtttggaatt ccacgacttg aaaggatcgt ccgcgggagt aataaaatca   2040

agttcgttgt taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta   2100

aaataaacac taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa   2160

aggttcctga aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag   2220

ctgttcgaac cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag   2280

agttttcctt tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc   2340

tcttcaatga gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg   2400

cgttatttga gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat   2460

tccgaagacc atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca   2520

aaattaagtt catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct   2580

cctctaagag ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag   2640

gtgttgaaga ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct   2700

cgaaagttga aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat   2760

ttggtgaagc tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta   2820

accctggctg tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct   2880

acctggaaat cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg   2940

tcattagacc atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag   3000

aaggccccgt gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag   3060

aaataaaaga gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga   3120

cctcttccct cctagggtaa atcagcttct gtgtcaggga tgctgtgtgg tgtccatctg   3180

aaccccctgc atacgcgtag ctaatgtgat ctccccactt tcacataaga tggtggccct   3240

gccttcaggg aatgtgggag ccaggtggga gccttcccgg atatttaagc tagaagattc   3300

tacagggaga ttctccttgg atcaatatat gtctctcagt caaagatgta aaagcacttt   3360

tgccttaaaa agaatgttct gtttctaaat agagtcaacg ttgtcctcct cattggaatt   3420

cactatgagt cagaatcatt agactgactt ttttttttcc atagtaatag tattttgcag   3480

agtctcacag agctgcagat cttttgttca tcttgcagag ttaacaagtc tgatcctgtt   3540

agtccagatt tcttaaattt ggccaagtta taataggagc agtagcttga gacccgaagt   3600

caggaaactt tgacaatgga tttttttttt taatccagag acttgtactg gaatttgcct   3660

taccctgtca gctcatggac ttaaggtttc atcccgcttt atgagtgctt ctgaatccaa   3720

gtcattgtta cctgaatttg caaattaagt tgtgatattc gtgactgtta aattcctgta   3780

attagattaa cctctttgct tgcttgtttg ttttctctcc tattttagct taaagtatca   3840

gtggttgaga agagcttttc ggacctgtta ctaccccaag ctgtgtaata tacttgtata   3900

acagaaatac cttctataca aacctttttt tctactttta gatagaaatg tctacttttt   3960

cagcagttct gtgaattaaa gagcagagtg actgtgggtc tggaatggct ggtgtacttg   4020

ggaatgtact atcaggattt tacagcaatg ctgggaaatg acagggaaaa tgacaggaat   4080

gaatctcacc agatttttta tgtactcagc agagccttga gttacggtgt ttattttcca   4140

atcaagtgaa gatatctcct acttctccta ctggaacatc tcagcttctg cagtgaagaa   4200

aaattcctgt gatagttcag ttctttagtt tttctatttg aaaaaaaaaa atcatttaaa   4260

tgatcctttg ttcacggctc tccttaatga ctgagtgaac agttcctatc tgtatatttg   4320

actaaacctt ttcctaagct atctctcatg gttcctatgt ttttttatca taattaaaag   4380

caaaaccatc tggatcacct aacagtcaga ggtcagtatc tcagcgtgtg aattatagag   4440

gaaatacaga gagaacctct tccactttta cttttcgtcc aaataaaatg catggtgtac   4500

cagaagttga agatcgggtt gaggattggg gctagctcga tgacactaag gccccaacat   4560

cgcgggacct gctgtggcgc ggattcttag gaacgctgtt ctagccggcc ccctctccag   4620

gggtcgccgt ggccggcatt atttcctagt tcttcttgta accctgaggt gccagcgcgg   4680

ggagtgagga ggggtcaggg ggctaaggat gcaacctctg acgttctgcg ccttcctagg   4740

agagtcttac atgtgttgag atttcacaag caatgcgagt tgtaaaatac cagctctaca   4800

agaagctagg ctctgtgacg gcatagtttt cagtagcttt atcacaatat tcacaatgga   4860

gaattatatg acatggtagc agaaataggc ccttttatgt gttgcttcta ttttacctca   4920

aattgtagat atagggtaat caataaaatc catccatgcc tttcacacac taagt        4975


<210>  5167
<211>  953
<212>  PRT
<213>  Homo sapiens

<400>  5167

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu 
    530                 535                 540


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
545                 550                 555                 560


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
                565                 570                 575


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
            580                 585                 590


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
        595                 600                 605


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
    610                 615                 620


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
625                 630                 635                 640


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
                645                 650                 655


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
            660                 665                 670


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
        675                 680                 685


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
    690                 695                 700


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
705                 710                 715                 720


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
                725                 730                 735


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
            740                 745                 750


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
        755                 760                 765


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
    770                 775                 780


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
785                 790                 795                 800


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
                805                 810                 815


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
            820                 825                 830


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
        835                 840                 845


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
    850                 855                 860


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
865                 870                 875                 880


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
                885                 890                 895


Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser 
            900                 905                 910


Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu 
        915                 920                 925


Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln 
    930                 935                 940


Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  5168
<211>  4530
<212>  DNA
<213>  Homo sapiens

<400>  5168
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctt agatttgttg acagcggttt cctggagtgc   2040

tgtcttgaga acgattctga ggaggctcag caagaaagag tgtttcagtt gattgggtgt   2100

gtctgtcatg gagaaggaac tcaagctctt ggactcaccg aggcagtaaa agtaccatat   2160

cctgtgtttg aatcaaaccc ggagttcttg tatgtggaag gcttgccaga ggggattccc   2220

ttccgaagcc ctacctggtt tggaattcca cgacttgaaa ggatcgtccg cgggagtaat   2280

aaaatcaagt tcgttgttaa aaaacctgaa ctagttattt cctacttgcc tcctgggatg   2340

gctagtaaaa taaacactaa agctttgcag tcccccaaaa gaccacgaag tcctgggagt   2400

aattcaaagg ttcctgaaat tgaggtcacc gtggaaggcc ctaataacaa caatcctcaa   2460

acctcagctg ttcgaacccc gacccagact aacggttcta acgttccctt caagccacga   2520

gggagagagt tttcctttga ggcctggaat gccaaaatca cggacctaaa acagaaagtt   2580

gaaaatctct tcaatgagaa atgtggggaa gctcttggcc ttaaacaagc tgtgaaggtg   2640

ccgttcgcgt tatttgagtc tttcccggaa gacttttatg tggaaggctt acctgagggt   2700

gtgccattcc gaagaccatc gacttttggc attccgaggc tggagaagat actcagaaac   2760

aaagccaaaa ttaagttcat cattaaaaag cccgaaatgt ttgagacggc gattaaggag   2820

agcacctcct ctaagagccc tcccagaaaa ataaattcat cacccaatgt taatactact   2880

gcatcaggtg ttgaagacct taacatcatt caggtgacaa ttccagatga tgataatgaa   2940

agactctcga aagttgaaaa agctagacag ctaagagaac aagtgaatga cctctttagt   3000

cggaaatttg gtgaagctat tggtatgggt tttcctgtga aagttcccta caggaaaatc   3060

acaattaacc ctggctgtgt ggtggttgat ggcatgcccc cgggggtgtc cttcaaagcc   3120

cccagctacc tggaaatcag ctccatgaga aggatcttag actctgccga gtttatcaaa   3180

ttcacggtca ttagaccatt tccaggactt gtgattaata accagctggt tgatcagagt   3240

gagtcagaag gccccgtgat acaagaatca gctgaaccaa gccagttgga agttccagcc   3300

acagaagaaa taaaagagac tgatggaagc tctcagatca agcaagaacc agaccccacg   3360

tggtagacct cttccctcct aggcttaaag tatcagtggt tgagaagagc ttttcggacc   3420

tgttactacc ccaagctgtg taatatactt gtataacaga aataccttct atacaaacct   3480

ttttttctac ttttagatag aaatgtctac tttttcagca gttctgtgaa ttaaagagca   3540

gagtgactgt gggtctggaa tggctggtgt acttgggaat gtactatcag gattttacag   3600

caatgctggg aaatgacagg gaaaatgaca ggaatgaatc tcaccagatt ttttatgtac   3660

tcagcagagc cttgagttac ggtgtttatt ttccaatcaa gtgaagatat ctcctacttc   3720

tcctactgga acatctcagc ttctgcagtg aagaaaaatt cctgtgatag ttcagttctt   3780

tagtttttct atttgaaaaa aaaaaatcat ttaaatgatc ctttgttcac ggctctcctt   3840

aatgactgag tgaacagttc ctatctgtat atttgactaa accttttcct aagctatctc   3900

tcatggttcc tatgtttttt tatcataatt aaaagcaaaa ccatctggat cacctaacag   3960

tcagaggtca gtatctcagc gtgtgaatta tagaggaaat acagagagaa cctcttccac   4020

ttttactttt cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc gggttgagga   4080

ttggggctag ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt ggcgcggatt   4140

cttaggaacg ctgttctagc cggccccctc tccaggggtc gccgtggccg gcattatttc   4200

ctagttcttc ttgtaaccct gaggtgccag cgcggggagt gaggaggggt cagggggcta   4260

aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg ttgagatttc   4320

acaagcaatg cgagttgtaa aataccagct ctacaagaag ctaggctctg tgacggcata   4380

gttttcagta gctttatcac aatattcaca atggagaatt atatgacatg gtagcagaaa   4440

taggcccttt tatgtgttgc ttctatttta cctcaaattg tagatatagg gtaatcaata   4500

aaatccatcc atgcctttca cacactaagt                                    4530


<210>  5169
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  5169

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala 
            580


<210>  5170
<211>  3980
<212>  DNA
<213>  Homo sapiens

<400>  5170
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag    960

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1020

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1080

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1140

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1200

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1260

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1320

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1380

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1440

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1500

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1560

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1620

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1680

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1740

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagctc   1800

aagctcttgg actcaccgag gcagtaaaag taccatatcc tgtgtttgaa tcaaacccgg   1860

agttcttgta tgtggaaggc ttgccagagg ggattccctt ccgaagccct acctggtttg   1920

gaattccacg acttgaaagg atcgtccgcg ggagtaataa aatcaagttc gttgttaaaa   1980

aacctgaact agttatttcc tacttgcctc ctgggatggc tagtaaaata aacactaaag   2040

ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa ttcaaaggtt cctgaaattg   2100

aggtcaccgt ggaaggccct aataacaaca atcctcaaac ctcagctgtt cgaaccccga   2160

cccagactaa cggttctaac gttcccttca agccacgagg gagagagttt tcctttgagg   2220

cctggaatgc caaaatcacg gacctaaaac agaaagttga aaatctcttc aatgagaaat   2280

gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc gttcgcgtta tttgagtctt   2340

tcccggaaga cttttatgtg gaaggcttac ctgagggtgt gccattccga agaccatcga   2400

cttttggcat tccgaggctg gagaagatac tcagaaacaa agccaaaatt aagttcatca   2460

ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag cacctcctct aagagccctc   2520

ccagaaaaat aaattcatca cccaatgtta atactactgc atcaggtgtt gaagacctta   2580

acatcattca ggtgacaatt ccagatgatg ataatgaaag actctcgaaa gttgaaaaag   2640

ctagacagct aagagaacaa gtgaatgacc tctttagtcg gaaatttggt gaagctattg   2700

gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac aattaaccct ggctgtgtgg   2760

tggttgatgg catgcccccg ggggtgtcct tcaaagcccc cagctacctg gaaatcagct   2820

ccatgagaag gatcttagac tctgccgagt ttatcaaatt cacggtcatt agaccatttc   2880

caggacttgt gattaataac cagctggttg atcagagtga gtcagaaggc cccgtgatac   2940

aagaatcagc tgaaccaagc cagttggaag ttccagccac agaagaaata aaagagactg   3000

atggaagctc tcagatcaag caagaaccag accccacgtg gtagacctct tccctcctag   3060

gcttaaagta tcagtggttg agaagagctt ttcggacctg ttactacccc aagctgtagc   3120

cttgagttac ggtgtttatt ttccaatcaa gtgaagatat ctcctacttc tcctactgga   3180

acatctcagc ttctgcagtg aagaaaaatt cctgtgatag ttcagttctt tagtttttct   3240

atttgaaaaa aaaaaatcat ttaaatgatc ctttgttcac ggctctcctt aatgactgag   3300

tgaacagttc ctatctgtat atttgactaa accttttcct aagctatctc tcatggttcc   3360

tatgtttttt tatcataatt aaaagcaaaa ccatctggat cacctaacag tcagaggtca   3420

gtatctcagc gtgtgaatta tagaggaaat acagagagaa cctcttccac ttttactttt   3480

cgtccaaata aaatgcatgg tgtaccagaa gttgaagatc gggttgagga ttggggctag   3540

ctcgatgaca ctaaggcccc aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg   3600

ctgttctagc cggccccctc tccaggggtc gccgtggccg gcattatttc ctagttcttc   3660

ttgtaaccct gaggtgccag cgcggggagt gaggaggggt cagggggcta aggatgcaac   3720

ctctgacgtt ctgcgccttc ctaggagagt cttacatgtg ttgagatttc acaagcaatg   3780

cgagttgtaa aataccagct ctacaagaag ctaggctctg tgacggcata gttttcagta   3840

gctttatcac aatattcaca atggagaatt atatgacatg gtagcagaaa taggcccttt   3900

tatgtgttgc ttctatttta cctcaaattg tagatatagg gtaatcaata aaatccatcc   3960

atgcctttca cacactaagt                                               3980


<210>  5171
<211>  928
<212>  PRT
<213>  Homo sapiens

<400>  5171

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro 
        515                 520                 525


Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu 
    530                 535                 540


Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu 
545                 550                 555                 560


Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro 
                565                 570                 575


Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn 
            580                 585                 590


Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn 
        595                 600                 605


Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn 
    610                 615                 620


Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser 
625                 630                 635                 640


Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp 
                645                 650                 655


Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn 
            660                 665                 670


Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro 
        675                 680                 685


Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu 
    690                 695                 700


Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg 
705                 710                 715                 720


Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys 
                725                 730                 735


Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys 
            740                 745                 750


Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala 
        755                 760                 765


Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp 
    770                 775                 780


Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu 
785                 790                 795                 800


Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met 
                805                 810                 815


Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly 
            820                 825                 830


Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro 
        835                 840                 845


Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu 
    850                 855                 860


Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn 
865                 870                 875                 880


Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu 
                885                 890                 895


Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys 
            900                 905                 910


Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
        915                 920                 925


<210>  5172
<211>  5084
<212>  DNA
<213>  Homo sapiens

<400>  5172
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag    960

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1020

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1080

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1140

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1200

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1260

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1320

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1380

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1440

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1500

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1560

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1620

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1680

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1740

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1800

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1860

tgaaatttgc ttagatttgt tgacagcggt ttcctggagt gctgtcttga gaacgattct   1920

gaggaggctc agcaagaaag agtgtttcag ttgattgggt gtgtctgtca tggagaagga   1980

actcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac   2040

ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg   2100

tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2160

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2220

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2280

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2340

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2400

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2460

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2520

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2580

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2640

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2700

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2760

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2820

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2880

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   2940

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3000

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca   3060

tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg   3120

atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag   3180

actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc   3240

ctagggtaaa tcagcttctg tgtcagggat gctgtgtggt gtccatctga accccctgca   3300

tacgcgtagc taatgtgatc tccccacttt cacataagat ggtggccctg ccttcaggga   3360

atgtgggagc caggtgggag ccttcccgga tatttaagct agaagattct acagggagat   3420

tctccttgga tcaatatatg tctctcagtc aaagatgtaa aagcactttt gccttaaaaa   3480

gaatgttctg tttctaaata gagtcaacgt tgtcctcctc attggaattc actatgagtc   3540

agaatcatta gactgacttt tttttttcca tagtaatagt attttgcaga gtctcacaga   3600

gctgcagatc ttttgttcat cttgcagagt taacaagtct gatcctgtta gtccagattt   3660

cttaaatttg gccaagttat aataggagca gtagcttgag acccgaagtc aggaaacttt   3720

gacaatggat tttttttttt aatccagaga cttgtactgg aatttgcctt accctgtcag   3780

ctcatggact taaggtttca tcccgcttta tgagtgcttc tgaatccaag tcattgttac   3840

ctgaatttgc aaattaagtt gtgatattcg tgactgttaa attcctgtaa ttagattaac   3900

ctctttgctt gcttgtttgt tttctctcct attttagctt aaagtatcag tggttgagaa   3960

gagcttttcg gacctgttac taccccaagc tgtgtaatat acttgtataa cagaaatacc   4020

ttctatacaa accttttttt ctacttttag atagaaatgt ctactttttc agcagttctg   4080

tgaattaaag agcagagtga ctgtgggtct ggaatggctg gtgtacttgg gaatgtacta   4140

tcaggatttt acagcaatgc tgggaaatga cagggaaaat gacaggaatg aatctcacca   4200

gattttttat gtactcagca gagccttgag ttacggtgtt tattttccaa tcaagtgaag   4260

atatctccta cttctcctac tggaacatct cagcttctgc agtgaagaaa aattcctgtg   4320

atagttcagt tctttagttt ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt   4380

tcacggctct ccttaatgac tgagtgaaca gttcctatct gtatatttga ctaaaccttt   4440

tcctaagcta tctctcatgg ttcctatgtt tttttatcat aattaaaagc aaaaccatct   4500

ggatcaccta acagtcagag gtcagtatct cagcgtgtga attatagagg aaatacagag   4560

agaacctctt ccacttttac ttttcgtcca aataaaatgc atggtgtacc agaagttgaa   4620

gatcgggttg aggattgggg ctagctcgat gacactaagg ccccaacatc gcgggacctg   4680

ctgtggcgcg gattcttagg aacgctgttc tagccggccc cctctccagg ggtcgccgtg   4740

gccggcatta tttcctagtt cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag   4800

gggtcagggg gctaaggatg caacctctga cgttctgcgc cttcctagga gagtcttaca   4860

tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc agctctacaa gaagctaggc   4920

tctgtgacgg catagttttc agtagcttta tcacaatatt cacaatggag aattatatga   4980

catggtagca gaaataggcc cttttatgtg ttgcttctat tttacctcaa attgtagata   5040

tagggtaatc aataaaatcc atccatgcct ttcacacact aagt                    5084


<210>  5173
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  5173

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535


<210>  5174
<211>  3661
<212>  DNA
<213>  Homo sapiens

<400>  5174
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag    960

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1020

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1080

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1140

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1200

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1260

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1320

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1380

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1440

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1500

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1560

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1620

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1680

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1740

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1800

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1860

tgaaatttgc tcaagctctt ggactcaccg aggcagtaaa agtaccatat cctgtgtttg   1920

aatcaaaccc ggagttcttg aaaggatcgt ccgcgggagt aataaaatca agttcgttgt   1980

taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta aaataaacac   2040

taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa aggttcctga   2100

aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag ctgttcgaac   2160

cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag agttttcctt   2220

tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc tcttcaatga   2280

gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg cgttatttga   2340

gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat tccgaagacc   2400

atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca aaattaagtt   2460

catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct cctctaagag   2520

ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag gtgttgaaga   2580

ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct cgaaagttga   2640

aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat ttggtgaagc   2700

tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta accctggctg   2760

tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct acctggaaat   2820

cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg tcattagacc   2880

atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag aaggccccgt   2940

gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag aaataaaaga   3000

gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga cctcttccct   3060

cctaggcaaa accatctgga tcacctaaca gtcagaggtc agtatctcag cgtgtgaatt   3120

atagaggaaa tacagagaga acctcttcca cttttacttt tcgtccaaat aaaatgcatg   3180

gtgtaccaga agttgaagat cgggttgagg attggggcta gctcgatgac actaaggccc   3240

caacatcgcg ggacctgctg tggcgcggat tcttaggaac gctgttctag ccggccccct   3300

ctccaggggt cgccgtggcc ggcattattt cctagttctt cttgtaaccc tgaggtgcca   3360

gcgcggggag tgaggagggg tcagggggct aaggatgcaa cctctgacgt tctgcgcctt   3420

cctaggagag tcttacatgt gttgagattt cacaagcaat gcgagttgta aaataccagc   3480

tctacaagaa gctaggctct gtgacggcat agttttcagt agctttatca caatattcac   3540

aatggagaat tatatgacat ggtagcagaa ataggccctt ttatgtgttg cttctatttt   3600

acctcaaatt gtagatatag ggtaatcaat aaaatccatc catgcctttc acacactaag   3660

t                                                                   3661


<210>  5175
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  5175

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr 
    530                 535                 540


Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe 
545                 550                 555                 560


Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys 
                565                 570                 575


Asn Leu Asn 



<210>  5176
<211>  7736
<212>  DNA
<213>  Homo sapiens

<400>  5176
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agctcaagct cttggactca ccgaggcagt aaaagtacca tatcctgtgt   1920

ttgaatcaaa cccggagttc ttgtatgtgg aaggcttgcc agaggggatt cccttccgaa   1980

gccctacctg gtttggaatt ccacgacttg aaaggatcgt ccgcgggagt aataaaatca   2040

agttcgttgt taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta   2100

aaataaacac taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa   2160

aggttcctga aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag   2220

ctgttcgaac cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag   2280

agttttcctt tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc   2340

tcttcaatga gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg   2400

cgttatttga gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat   2460

tccgaagacc atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca   2520

aaattaagtt catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct   2580

cctctaagag ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag   2640

gtgttgaaga ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct   2700

cgaaagttga aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat   2760

ttggtgaagc tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta   2820

accctggctg tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct   2880

acctggaaat cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg   2940

tcattaggta agtgagagtt tcctgcttag tcacaggagc gaatctggag ctcatgaggc   3000

tgactcttct aaaatgcagc cacaggtagt catcgaatcc ggcttcctat gctgtgcaat   3060

caacaaatca aaataacttg tgtcatcatt agaatgtcag atgtgcttct acgaactaag   3120

ctgactcttt taattctttg gcaaagggtt ggcaaactag gactgtttgc caaattcagg   3180

ctgcctccta tttttagagt cttcctgaaa cacagctaca cccgtattat ccatggctgc   3240

tttcctgtca cagtgagtaa gtagctggga ctgagaaggc atggcctcca aagtctaaaa   3300

tatttactct ctagcacttt gtagaaaaac cttagctagg cacagtggct aacgcctgta   3360

atcccagcat tttgggaggc caaggcaggc agatcacctg aggtcaggag ttccagacca   3420

gcctggccaa catggtgaaa tcccatctct acaaaaataa aacagttagc tgggcatgat   3480

ggcgggtgcc tgtaatccca gctactcggg aggctgaggc aggatagtcg cttgaaccca   3540

ggaggtggag gttgcaatga gccaagatca tgccactgca ctccagcctg gacgacagag   3600

tgagactcca tcacaagaaa aaaagaactt tgtcaacctc tgtcttaggg cgccttgtca   3660

caggcttcgg gtcagacgga ttcaaccttg catcagccat ttgttagcca ggtcactctg   3720

ttctttgtct gtaaatgaga ttgatcgttg ttcccactga gagtgtcagc tccttcccgt   3780

agagcaggca tgatgattgt actcacctct gacaccattg tgagtgccac attccttccc   3840

acgtccttgt cactgtaaga gatgcccacc tgagcaccaa ccccaggtta tcttcccctt   3900

tgtcttccag ccccccagaa acagctacga ctcaacctac ccaatcattt catcatcaga   3960

ttgccactgt ctctagttca ggtctcttgg gactggcact cagaaatctc ataataaatc   4020

ctcttgaggc ttctcataca ctcgtcttct tccaatcttc tttccctcaa aatctcatat   4080

tttggttcca cttcacccac cgtcattctc catatcactc ccaggagtta ggcaaaaagc   4140

cccttccgtt cttccgtatg ttaaacttag aatcactctg ttccctgctc tgcgtttcta   4200

ttttttgttt ttcctccatt tactagtagc ttaacacttt ctaacagtgt tcttattatt   4260

gatacgtatc tatctcttcc ataagcttat aaggtcacgg ataatacttc tcattgtagt   4320

acgtaaatga cgtgggctag atatgagttg aataaacagt tatacctgta aattcttaca   4380

gagtgaaaat aaattgttat actttacaat ttgtttctct ctttagacca tttccaggac   4440

ttgtgattaa taaccgtgag tattttgtga agtgttttgt ttttgttttt tcctggggtc   4500

tgacgtgtgt gcgtgtgagt gtgtatacat gcttaacgta tatcacgtta cttcacctat   4560

gtcagtaacc aggccaaata cttgttttag ccctcagtaa aaacaccagg cacttcctag   4620

ttgtaaaatt attcaagctt cttaacttcc tatcctcgat gcacttaatc ataaaatggt   4680

aataatagca ccgattttgg gggagtcgtt ccagtagatg gaaagcatct ggaacaggtg   4740

tcagcaagct cctgccgacg tgtatgcata aagttttatt gaaaccacca tcgtgtccat   4800

ttgtttatgg cagaactgag agatggcagc agcaagtgtg tgcctgcaaa acctaaaata   4860

tttactaatt ggctctgcaa gaaaagagtt tgcatccccc taacctagaa cagtgtctag   4920

cctctagtat gtgtttagcc tacagtatgt gctcagcgaa tacaatctat atttattact   4980

gcttttatga ctgttataat tactgtgctt ggatttcgtt acaaagtaag tcacaatgtg   5040

cctgcttctg ttagtatttc agcacagtgc ctggcacaca tggggctctc aaatattgct   5100

gagcgagtga acaaatgtcc tttcaattcc ttaacgttga tgtcattttc aatagtattt   5160

tgagccaaac ttaattttgc gagtgtgttt tgttttctta actttattat taaaaatgta   5220

taaaagtgag gccaggcgtg gtggctcacg cctgtaatcc cagcagtttg ggaggctgag   5280

gcaggcggat cagttgaggt tgggagttgg agaccagccc gtccaacatg gtgaaagcct   5340

gtctctacta aaaatacaaa aatcagctgg gtgtggtggc gcgtgcctgt aatcccagct   5400

actcaggagg ctgaggcagg agagttgctt gaatcctaga ggtggaggtt gcagtgagct   5460

gagatcgtgc cattgcactc cagcctgggc aacaagagca aaactctgtc ccaataaata   5520

aataaataaa atgttctctt ttgttcctgt tcttgtgcgg tagtgtggta tagagtttta   5580

tggtaattac tgtgaattag tgattctgag ggacatatca gaactctgag gtttgtttcc   5640

ttctcatctt gagggaaaca gcaaatgtat gttaaaatgc ttttccaagg gaacaacaca   5700

tccttacatt atttaaacca atctgcttca ttttcagagc tggttgatca gagtgagtca   5760

gaaggccccg tgatacaaga atcagctgaa ccaagccagt tggaagttcc agccacagaa   5820

gaaataaaag agactgatgg aagctctcag atcaagcaag aaccagaccc cacgtggtag   5880

acctcttccc tcctagggta aatcagcttc tgtgtcaggg atgctgtgtg gtgtccatct   5940

gaaccccctg catacgcgta gctaatgtga tctccccact ttcacataag atggtggccc   6000

tgccttcagg gaatgtggga gccaggtggg agccttcccg gatatttaag ctagaagatt   6060

ctacagggag attctccttg gatcaatata tgtctctcag tcaaagatgt aaaagcactt   6120

ttgccttaaa aagaatgttc tgtttctaaa tagagtcaac gttgtcctcc tcattggaat   6180

tcactatgag tcagaatcat tagactgact tttttttttc catagtaata gtattttgca   6240

gagtctcaca gagctgcaga tcttttgttc atcttgcaga gttaacaagt ctgatcctgt   6300

tagtccagat ttcttaaatt tggccaagtt ataataggag cagtagcttg agacccgaag   6360

tcaggaaact ttgacaatgg attttttttt ttaatccaga gacttgtact ggaatttgcc   6420

ttaccctgtc agctcatgga cttaaggttt catcccgctt tatgagtgct tctgaatcca   6480

agtcattgtt acctgaattt gcaaattaag ttgtgatatt cgtgactgtt aaattcctgt   6540

aattagatta acctctttgc ttgcttgttt gttttctctc ctattttagc ttaaagtatc   6600

agtggttgag aagagctttt cggacctgtt actaccccaa gctgtgtaat atacttgtat   6660

aacagaaata ccttctatac aaaccttttt ttctactttt agatagaaat gtctactttt   6720

tcagcagttc tgtgaattaa agagcagagt gactgtgggt ctggaatggc tggtgtactt   6780

gggaatgtac tatcaggatt ttacagcaat gctgggaaat gacagggaaa atgacaggaa   6840

tgaatctcac cagatttttt atgtactcag cagagccttg agttacggtg tttattttcc   6900

aatcaagtga agatatctcc tacttctcct actggaacat ctcagcttct gcagtgaaga   6960

aaaattcctg tgatagttca gttctttagt ttttctattt gaaaaaaaaa aatcatttaa   7020

atgatccttt gttcacggct ctccttaatg actgagtgaa cagttcctat ctgtatattt   7080

gactaaacct tttcctaagc tatctctcat ggttcctatg tttttttatc ataattaaaa   7140

gcaaaaccat ctggatcacc taacagtcag aggtcagtat ctcagcgtgt gaattataga   7200

ggaaatacag agagaacctc ttccactttt acttttcgtc caaataaaat gcatggtgta   7260

ccagaagttg aagatcgggt tgaggattgg ggctagctcg atgacactaa ggccccaaca   7320

tcgcgggacc tgctgtggcg cggattctta ggaacgctgt tctagccggc cccctctcca   7380

ggggtcgccg tggccggcat tatttcctag ttcttcttgt aaccctgagg tgccagcgcg   7440

gggagtgagg aggggtcagg gggctaagga tgcaacctct gacgttctgc gccttcctag   7500

gagagtctta catgtgttga gatttcacaa gcaatgcgag ttgtaaaata ccagctctac   7560

aagaagctag gctctgtgac ggcatagttt tcagtagctt tatcacaata ttcacaatgg   7620

agaattatat gacatggtag cagaaatagg cccttttatg tgttgcttct attttacctc   7680

aaattgtaga tatagggtaa tcaataaaat ccatccatgc ctttcacaca ctaagt       7736


<210>  5177
<211>  897
<212>  PRT
<213>  Homo sapiens

<400>  5177

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu 
    530                 535                 540


Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu 
545                 550                 555                 560


Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro 
                565                 570                 575


Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn 
            580                 585                 590


Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu 
        595                 600                 605


Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro 
    610                 615                 620


Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu 
625                 630                 635                 640


Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val 
                645                 650                 655


Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg 
            660                 665                 670


Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu 
        675                 680                 685


Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu 
    690                 695                 700


Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe 
705                 710                 715                 720


Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg 
                725                 730                 735


Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn 
            740                 745                 750


Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr 
        755                 760                 765


Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn 
    770                 775                 780


Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn 
785                 790                 795                 800


Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys 
                805                 810                 815


Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser 
            820                 825                 830


Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro 
        835                 840                 845


Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met 
    850                 855                 860


Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser 
865                 870                 875                 880


Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile 
                885                 890                 895


Arg 



<210>  5178
<211>  3794
<212>  DNA
<213>  Homo sapiens

<400>  5178
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   1980

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   2040

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2100

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2160

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2220

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2280

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2340

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2400

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2460

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2520

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2580

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2640

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2700

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2760

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2820

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2880

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   2940

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   3000

cggtcattag accatttcca ggacttgtga ttaataacca gctggttgat cagagtgagt   3060

cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt ccagccacag   3120

aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac cccacgtggt   3180

agacctcttc cctcctaggc aaaaccatct ggatcaccta acagtcagag gtcagtatct   3240

cagcgtgtga attatagagg aaatacagag agaacctctt ccacttttac ttttcgtcca   3300

aataaaatgc atggtgtacc agaagttgaa gatcgggttg aggattgggg ctagctcgat   3360

gacactaagg ccccaacatc gcgggacctg ctgtggcgcg gattcttagg aacgctgttc   3420

tagccggccc cctctccagg ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa   3480

ccctgaggtg ccagcgcggg gagtgaggag gggtcagggg gctaaggatg caacctctga   3540

cgttctgcgc cttcctagga gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt   3600

gtaaaatacc agctctacaa gaagctaggc tctgtgacgg catagttttc agtagcttta   3660

tcacaatatt cacaatggag aattatatga catggtagca gaaataggcc cttttatgtg   3720

ttgcttctat tttacctcaa attgtagata tagggtaatc aataaaatcc atccatgcct   3780

ttcacacact aagt                                                     3794


<210>  5179
<211>  974
<212>  PRT
<213>  Homo sapiens

<400>  5179

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala 
545                 550                 555                 560


Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe 
                565                 570                 575


Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile 
            580                 585                 590


Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile 
        595                 600                 605


Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu 
    610                 615                 620


Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys 
625                 630                 635                 640


Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys 
                645                 650                 655


Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro 
            660                 665                 670


Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val 
        675                 680                 685


Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala 
    690                 695                 700


Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys 
705                 710                 715                 720


Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala 
                725                 730                 735


Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu 
            740                 745                 750


Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu 
        755                 760                 765


Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro 
    770                 775                 780


Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro 
785                 790                 795                 800


Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly 
                805                 810                 815


Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn 
            820                 825                 830


Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val 
        835                 840                 845


Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe 
    850                 855                 860


Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val 
865                 870                 875                 880


Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr 
                885                 890                 895


Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile 
            900                 905                 910


Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln 
        915                 920                 925


Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala 
    930                 935                 940


Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr 
945                 950                 955                 960


Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
                965                 970


<210>  5180
<211>  4190
<212>  DNA
<213>  Homo sapiens

<400>  5180
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040

taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2100

ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2160

ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2220

ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2280

ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2340

atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2400

agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2460

agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2520

tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2580

ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2640

tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2700

ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2760

atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2820

ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2880

tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   2940

ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   3000

tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3060

ttatcaaatt cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg   3120

atcagagtga gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag   3180

ttccagccac agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag   3240

accccacgtg gtagacctct tccctcctag gcttaaagta tcagtggttg agaagagctt   3300

ttcggacctg ttactacccc aagctgtagc cttgagttac ggtgtttatt ttccaatcaa   3360

gtgaagatat ctcctacttc tcctactgga acatctcagc ttctgcagtg aagaaaaatt   3420

cctgtgatag ttcagttctt tagtttttct atttgaaaaa aaaaaatcat ttaaatgatc   3480

ctttgttcac ggctctcctt aatgactgag tgaacagttc ctatctgtat atttgactaa   3540

accttttcct aagctatctc tcatggttcc tatgtttttt tatcataatt aaaagcaaaa   3600

ccatctggat cacctaacag tcagaggtca gtatctcagc gtgtgaatta tagaggaaat   3660

acagagagaa cctcttccac ttttactttt cgtccaaata aaatgcatgg tgtaccagaa   3720

gttgaagatc gggttgagga ttggggctag ctcgatgaca ctaaggcccc aacatcgcgg   3780

gacctgctgt ggcgcggatt cttaggaacg ctgttctagc cggccccctc tccaggggtc   3840

gccgtggccg gcattatttc ctagttcttc ttgtaaccct gaggtgccag cgcggggagt   3900

gaggaggggt cagggggcta aggatgcaac ctctgacgtt ctgcgccttc ctaggagagt   3960

cttacatgtg ttgagatttc acaagcaatg cgagttgtaa aataccagct ctacaagaag   4020

ctaggctctg tgacggcata gttttcagta gctttatcac aatattcaca atggagaatt   4080

atatgacatg gtagcagaaa taggcccttt tatgtgttgc ttctatttta cctcaaattg   4140

tagatatagg gtaatcaata aaatccatcc atgcctttca cacactaagt              4190


<210>  5181
<211>  998
<212>  PRT
<213>  Homo sapiens

<400>  5181

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr 
        595                 600                 605


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe 
    610                 615                 620


Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys 
625                 630                 635                 640


Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly 
                645                 650                 655


Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro 
            660                 665                 670


Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val 
        675                 680                 685


Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro 
    690                 695                 700


Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu 
705                 710                 715                 720


Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys 
                725                 730                 735


Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys 
            740                 745                 750


Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp 
        755                 760                 765


Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser 
    770                 775                 780


Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys 
785                 790                 795                 800


Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys 
                805                 810                 815


Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro 
            820                 825                 830


Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln 
        835                 840                 845


Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys 
    850                 855                 860


Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe 
865                 870                 875                 880


Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys 
                885                 890                 895


Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly 
            900                 905                 910


Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg 
        915                 920                 925


Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe 
    930                 935                 940


Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu 
945                 950                 955                 960


Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro 
                965                 970                 975


Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln 
            980                 985                 990


Glu Pro Asp Pro Thr Trp 
        995


<210>  5182
<211>  6969
<212>  DNA
<213>  Homo sapiens

<400>  5182
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag    960

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1020

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1080

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1140

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1200

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1260

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1320

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1380

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1440

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1500

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1560

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1620

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1680

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1740

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagctc   1800

aagctcttgg actcaccgag gcagtaaaag taccatatcc tgtgtttgaa tcaaacccgg   1860

agttcttgta tgtggaaggc ttgccagagg ggattccctt ccgaagccct acctggtttg   1920

gaattccacg acttgaaagg atcgtccgcg ggagtaataa aatcaagttc gttgttaaaa   1980

aacctgaact agttatttcc tacttgcctc ctgggatggc tagtaaaata aacactaaag   2040

ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa ttcaaaggtt cctgaaattg   2100

aggtcaccgt ggaaggccct aataacaaca atcctcaaac ctcagctgtt cgaaccccga   2160

cccagactaa cggttctaac gttcccttca agccacgagg gagagagttt tcctttgagg   2220

cctggaatgc caaaatcacg gacctaaaac agaaagttga aaatctcttc aatgagaaat   2280

gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc gttcgcgtta tttgagtctt   2340

tcccggaaga cttttatgtg gaaggcttac ctgagggtgt gccattccga agaccatcga   2400

cttttggcat tccgaggctg gagaagatac tcagaaacaa agccaaaatt aagttcatca   2460

ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag cacctcctct aagagccctc   2520

ccagaaaaat aaattcatca cccaatgtta atactactgc atcaggtgtt gaagacctta   2580

acatcattca ggtgacaatt ccagatgatg ataatgaaag actctcgaaa gttgaaaaag   2640

ctagacagct aagagaacaa gtgaatgacc tctttagtcg gaaatttggt gaagctattg   2700

gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac aattaaccct ggctgtgtgg   2760

tggttgatgg catgcccccg ggggtgtcct tcaaagcccc cagctacctg gaaatcagct   2820

ccatgagaag gatcttagac tctgccgagt ttatcaaatt cacggtcatt aggtaagtga   2880

gagtttcctg cttagtcaca ggagcgaatc tggagctcat gaggctgact cttctaaaat   2940

gcagccacag gtagtcatcg aatccggctt cctatgctgt gcaatcaaca aatcaaaata   3000

acttgtgtca tcattagaat gtcagatgtg cttctacgaa ctaagctgac tcttttaatt   3060

ctttggcaaa gggttggcaa actaggactg tttgccaaat tcaggctgcc tcctattttt   3120

agagtcttcc tgaaacacag ctacacccgt attatccatg gctgctttcc tgtcacagtg   3180

agtaagtagc tgggactgag aaggcatggc ctccaaagtc taaaatattt actctctagc   3240

actttgtaga aaaaccttag ctaggcacag tggctaacgc ctgtaatccc agcattttgg   3300

gaggccaagg caggcagatc acctgaggtc aggagttcca gaccagcctg gccaacatgg   3360

tgaaatccca tctctacaaa aataaaacag ttagctgggc atgatggcgg gtgcctgtaa   3420

tcccagctac tcgggaggct gaggcaggat agtcgcttga acccaggagg tggaggttgc   3480

aatgagccaa gatcatgcca ctgcactcca gcctggacga cagagtgaga ctccatcaca   3540

agaaaaaaag aactttgtca acctctgtct tagggcgcct tgtcacaggc ttcgggtcag   3600

acggattcaa ccttgcatca gccatttgtt agccaggtca ctctgttctt tgtctgtaaa   3660

tgagattgat cgttgttccc actgagagtg tcagctcctt cccgtagagc aggcatgatg   3720

attgtactca cctctgacac cattgtgagt gccacattcc ttcccacgtc cttgtcactg   3780

taagagatgc ccacctgagc accaacccca ggttatcttc ccctttgtct tccagccccc   3840

cagaaacagc tacgactcaa cctacccaat catttcatca tcagattgcc actgtctcta   3900

gttcaggtct cttgggactg gcactcagaa atctcataat aaatcctctt gaggcttctc   3960

atacactcgt cttcttccaa tcttctttcc ctcaaaatct catattttgg ttccacttca   4020

cccaccgtca ttctccatat cactcccagg agttaggcaa aaagcccctt ccgttcttcc   4080

gtatgttaaa cttagaatca ctctgttccc tgctctgcgt ttctattttt tgtttttcct   4140

ccatttacta gtagcttaac actttctaac agtgttctta ttattgatac gtatctatct   4200

cttccataag cttataaggt cacggataat acttctcatt gtagtacgta aatgacgtgg   4260

gctagatatg agttgaataa acagttatac ctgtaaattc ttacagagtg aaaataaatt   4320

gttatacttt acaatttgtt tctctcttta gaccatttcc aggacttgtg attaataacc   4380

gtgagtattt tgtgaagtgt tttgtttttg ttttttcctg gggtctgacg tgtgtgcgtg   4440

tgagtgtgta tacatgctta acgtatatca cgttacttca cctatgtcag taaccaggcc   4500

aaatacttgt tttagccctc agtaaaaaca ccaggcactt cctagttgta aaattattca   4560

agcttcttaa cttcctatcc tcgatgcact taatcataaa atggtaataa tagcaccgat   4620

tttgggggag tcgttccagt agatggaaag catctggaac aggtgtcagc aagctcctgc   4680

cgacgtgtat gcataaagtt ttattgaaac caccatcgtg tccatttgtt tatggcagaa   4740

ctgagagatg gcagcagcaa gtgtgtgcct gcaaaaccta aaatatttac taattggctc   4800

tgcaagaaaa gagtttgcat ccccctaacc tagaacagtg tctagcctct agtatgtgtt   4860

tagcctacag tatgtgctca gcgaatacaa tctatattta ttactgcttt tatgactgtt   4920

ataattactg tgcttggatt tcgttacaaa gtaagtcaca atgtgcctgc ttctgttagt   4980

atttcagcac agtgcctggc acacatgggg ctctcaaata ttgctgagcg agtgaacaaa   5040

tgtcctttca attccttaac gttgatgtca ttttcaatag tattttgagc caaacttaat   5100

tttgcgagtg tgttttgttt tcttaacttt attattaaaa atgtataaaa gtgaggccag   5160

gcgtggtggc tcacgcctgt aatcccagca gtttgggagg ctgaggcagg cggatcagtt   5220

gaggttggga gttggagacc agcccgtcca acatggtgaa agcctgtctc tactaaaaat   5280

acaaaaatca gctgggtgtg gtggcgcgtg cctgtaatcc cagctactca ggaggctgag   5340

gcaggagagt tgcttgaatc ctagaggtgg aggttgcagt gagctgagat cgtgccattg   5400

cactccagcc tgggcaacaa gagcaaaact ctgtcccaat aaataaataa ataaaatgtt   5460

ctcttttgtt cctgttcttg tgcggtagtg tggtatagag ttttatggta attactgtga   5520

attagtgatt ctgagggaca tatcagaact ctgaggtttg tttccttctc atcttgaggg   5580

aaacagcaaa tgtatgttaa aatgcttttc caagggaaca acacatcctt acattattta   5640

aaccaatctg cttcattttc agagctggtt gatcagagtg agtcagaagg ccccgtgata   5700

caagaatcag ctgaaccaag ccagttggaa gttccagcca cagaagaaat aaaagagact   5760

gatggaagct ctcagatcaa gcaagaacca gaccccacgt ggtagacctc ttccctccta   5820

ggcttaaagt atcagtggtt gagaagagct tttcggacct gttactaccc caagctgtgt   5880

aatatacttg tataacagaa ataccttcta tacaaacctt tttttctact tttagataga   5940

aatgtctact ttttcagcag ttctgtgaat taaagagcag agtgactgtg ggtctggaat   6000

ggctggtgta cttgggaatg tactatcagg attttacagc aatgctggga aatgacaggg   6060

aaaatgacag gaatgaatct caccagattt tttatgtact cagcagagcc ttgagttacg   6120

gtgtttattt tccaatcaag tgaagatatc tcctacttct cctactggaa catctcagct   6180

tctgcagtga agaaaaattc ctgtgatagt tcagttcttt agtttttcta tttgaaaaaa   6240

aaaaatcatt taaatgatcc tttgttcacg gctctcctta atgactgagt gaacagttcc   6300

tatctgtata tttgactaaa ccttttccta agctatctct catggttcct atgttttttt   6360

atcataatta aaagcaaaac catctggatc acctaacagt cagaggtcag tatctcagcg   6420

tgtgaattat agaggaaata cagagagaac ctcttccact tttacttttc gtccaaataa   6480

aatgcatggt gtaccagaag ttgaagatcg ggttgaggat tggggctagc tcgatgacac   6540

taaggcccca acatcgcggg acctgctgtg gcgcggattc ttaggaacgc tgttctagcc   6600

ggccccctct ccaggggtcg ccgtggccgg cattatttcc tagttcttct tgtaaccctg   6660

aggtgccagc gcggggagtg aggaggggtc agggggctaa ggatgcaacc tctgacgttc   6720

tgcgccttcc taggagagtc ttacatgtgt tgagatttca caagcaatgc gagttgtaaa   6780

ataccagctc tacaagaagc taggctctgt gacggcatag ttttcagtag ctttatcaca   6840

atattcacaa tggagaatta tatgacatgg tagcagaaat aggccctttt atgtgttgct   6900

tctattttac ctcaaattgt agatataggg taatcaataa aatccatcca tgcctttcac   6960

acactaagt                                                           6969


<210>  5183
<211>  872
<212>  PRT
<213>  Homo sapiens

<400>  5183

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro 
        515                 520                 525


Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu 
    530                 535                 540


Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu 
545                 550                 555                 560


Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro 
                565                 570                 575


Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn 
            580                 585                 590


Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn 
        595                 600                 605


Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn 
    610                 615                 620


Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser 
625                 630                 635                 640


Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp 
                645                 650                 655


Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn 
            660                 665                 670


Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro 
        675                 680                 685


Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu 
    690                 695                 700


Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg 
705                 710                 715                 720


Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys 
                725                 730                 735


Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys 
            740                 745                 750


Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala 
        755                 760                 765


Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp 
    770                 775                 780


Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu 
785                 790                 795                 800


Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met 
                805                 810                 815


Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly 
            820                 825                 830


Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro 
        835                 840                 845


Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu 
    850                 855                 860


Phe Ile Lys Phe Thr Val Ile Arg 
865                 870


<210>  5184
<211>  4980
<212>  DNA
<213>  Homo sapiens

<400>  5184
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1980

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   2040

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2100

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2160

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2220

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2280

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2340

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2400

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2460

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2520

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2580

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2640

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2700

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2760

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2820

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2880

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   2940

cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg atcagagtga   3000

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   3060

agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag accccacgtg   3120

gtagacctct tccctcctag ggtaaatcag cttctgtgtc agggatgctg tgtggtgtcc   3180

atctgaaccc cctgcatacg cgtagctaat gtgatctccc cactttcaca taagatggtg   3240

gccctgcctt cagggaatgt gggagccagg tgggagcctt cccggatatt taagctagaa   3300

gattctacag ggagattctc cttggatcaa tatatgtctc tcagtcaaag atgtaaaagc   3360

acttttgcct taaaaagaat gttctgtttc taaatagagt caacgttgtc ctcctcattg   3420

gaattcacta tgagtcagaa tcattagact gacttttttt tttccatagt aatagtattt   3480

tgcagagtct cacagagctg cagatctttt gttcatcttg cagagttaac aagtctgatc   3540

ctgttagtcc agatttctta aatttggcca agttataata ggagcagtag cttgagaccc   3600

gaagtcagga aactttgaca atggattttt ttttttaatc cagagacttg tactggaatt   3660

tgccttaccc tgtcagctca tggacttaag gtttcatccc gctttatgag tgcttctgaa   3720

tccaagtcat tgttacctga atttgcaaat taagttgtga tattcgtgac tgttaaattc   3780

ctgtaattag attaacctct ttgcttgctt gtttgttttc tctcctattt tagcttaaag   3840

tatcagtggt tgagaagagc ttttcggacc tgttactacc ccaagctgtg taatatactt   3900

gtataacaga aataccttct atacaaacct ttttttctac ttttagatag aaatgtctac   3960

tttttcagca gttctgtgaa ttaaagagca gagtgactgt gggtctggaa tggctggtgt   4020

acttgggaat gtactatcag gattttacag caatgctggg aaatgacagg gaaaatgaca   4080

ggaatgaatc tcaccagatt ttttatgtac tcagcagagc cttgagttac ggtgtttatt   4140

ttccaatcaa gtgaagatat ctcctacttc tcctactgga acatctcagc ttctgcagtg   4200

aagaaaaatt cctgtgatag ttcagttctt tagtttttct atttgaaaaa aaaaaatcat   4260

ttaaatgatc ctttgttcac ggctctcctt aatgactgag tgaacagttc ctatctgtat   4320

atttgactaa accttttcct aagctatctc tcatggttcc tatgtttttt tatcataatt   4380

aaaagcaaaa ccatctggat cacctaacag tcagaggtca gtatctcagc gtgtgaatta   4440

tagaggaaat acagagagaa cctcttccac ttttactttt cgtccaaata aaatgcatgg   4500

tgtaccagaa gttgaagatc gggttgagga ttggggctag ctcgatgaca ctaaggcccc   4560

aacatcgcgg gacctgctgt ggcgcggatt cttaggaacg ctgttctagc cggccccctc   4620

tccaggggtc gccgtggccg gcattatttc ctagttcttc ttgtaaccct gaggtgccag   4680

cgcggggagt gaggaggggt cagggggcta aggatgcaac ctctgacgtt ctgcgccttc   4740

ctaggagagt cttacatgtg ttgagatttc acaagcaatg cgagttgtaa aataccagct   4800

ctacaagaag ctaggctctg tgacggcata gttttcagta gctttatcac aatattcaca   4860

atggagaatt atatgacatg gtagcagaaa taggcccttt tatgtgttgc ttctatttta   4920

cctcaaattg tagatatagg gtaatcaata aaatccatcc atgcctttca cacactaagt   4980


<210>  5185
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  5185

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
                565                 570                 575


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly 
            580                 585                 590


Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu Asn 
        595                 600


<210>  5186
<211>  5033
<212>  DNA
<213>  Homo sapiens

<400>  5186
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag    960

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1020

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1080

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1140

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1200

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1260

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1320

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1380

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1440

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1500

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1560

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1620

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1680

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1740

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1800

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1860

tgaaatttgc ttagatttgt tgacagcggt ttcctggagt gctgtcttga gaacgattct   1920

gaggaggctc agcaagaaag agtgtttcag ttgattgggt gtgtctgtca tggagaagga   1980

actcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac   2040

ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg   2100

tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2160

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2220

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2280

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2340

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2400

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2460

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2520

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2580

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2640

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2700

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2760

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2820

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2880

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   2940

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3000

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca   3060

tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg   3120

atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaagg taaaaggacc   3180

tcttccctcc tagggtaaat cagcttctgt gtcagggatg ctgtgtggtg tccatctgaa   3240

ccccctgcat acgcgtagct aatgtgatct ccccactttc acataagatg gtggccctgc   3300

cttcagggaa tgtgggagcc aggtgggagc cttcccggat atttaagcta gaagattcta   3360

cagggagatt ctccttggat caatatatgt ctctcagtca aagatgtaaa agcacttttg   3420

ccttaaaaag aatgttctgt ttctaaatag agtcaacgtt gtcctcctca ttggaattca   3480

ctatgagtca gaatcattag actgactttt ttttttccat agtaatagta ttttgcagag   3540

tctcacagag ctgcagatct tttgttcatc ttgcagagtt aacaagtctg atcctgttag   3600

tccagatttc ttaaatttgg ccaagttata ataggagcag tagcttgaga cccgaagtca   3660

ggaaactttg acaatggatt ttttttttta atccagagac ttgtactgga atttgcctta   3720

ccctgtcagc tcatggactt aaggtttcat cccgctttat gagtgcttct gaatccaagt   3780

cattgttacc tgaatttgca aattaagttg tgatattcgt gactgttaaa ttcctgtaat   3840

tagattaacc tctttgcttg cttgtttgtt ttctctccta ttttagctta aagtatcagt   3900

ggttgagaag agcttttcgg acctgttact accccaagct gtgtaatata cttgtataac   3960

agaaatacct tctatacaaa cctttttttc tacttttaga tagaaatgtc tactttttca   4020

gcagttctgt gaattaaaga gcagagtgac tgtgggtctg gaatggctgg tgtacttggg   4080

aatgtactat caggatttta cagcaatgct gggaaatgac agggaaaatg acaggaatga   4140

atctcaccag attttttatg tactcagcag agccttgagt tacggtgttt attttccaat   4200

caagtgaaga tatctcctac ttctcctact ggaacatctc agcttctgca gtgaagaaaa   4260

attcctgtga tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat catttaaatg   4320

atcctttgtt cacggctctc cttaatgact gagtgaacag ttcctatctg tatatttgac   4380

taaacctttt cctaagctat ctctcatggt tcctatgttt ttttatcata attaaaagca   4440

aaaccatctg gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa ttatagagga   4500

aatacagaga gaacctcttc cacttttact tttcgtccaa ataaaatgca tggtgtacca   4560

gaagttgaag atcgggttga ggattggggc tagctcgatg acactaaggc cccaacatcg   4620

cgggacctgc tgtggcgcgg attcttagga acgctgttct agccggcccc ctctccaggg   4680

gtcgccgtgg ccggcattat ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg   4740

agtgaggagg ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc ttcctaggag   4800

agtcttacat gtgttgagat ttcacaagca atgcgagttg taaaatacca gctctacaag   4860

aagctaggct ctgtgacggc atagttttca gtagctttat cacaatattc acaatggaga   4920

attatatgac atggtagcag aaataggccc ttttatgtgt tgcttctatt ttacctcaaa   4980

ttgtagatat agggtaatca ataaaatcca tccatgcctt tcacacacta agt          5033


<210>  5187
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  5187

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535


<210>  5188
<211>  4071
<212>  DNA
<213>  Homo sapiens

<400>  5188
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1980

catatcctgt gtttgaatca aacccggagt tcttgtatgt ggaaggcttg ccagagggga   2040

ttcccttccg aagccctacc tggtttggaa ttccacgact tgaaaggatc gtccgcggga   2100

gtaataaaat caagttcgtt gttaaaaaac ctgaactagt tatttcctac ttgcctcctg   2160

ggatggctag taaaataaac actaaagctt tgcagtcccc caaaagacca cgaagtcctg   2220

ggagtaattc aaaggttcct gaaattgagg tcaccgtgga aggccctaat aacaacaatc   2280

ctcaaacctc agctgttcga accccgaccc agactaacgg ttctaacgtt cccttcaagc   2340

cacgagggag agagttttcc tttgaggcct ggaatgccaa aatcacggac ctaaaacaga   2400

aagttgaaaa tctcttcaat gagaaatgtg gggaagctct tggccttaaa caagctgtga   2460

aggtgccgtt cgcgttattt gagtctttcc cggaagactt ttatgtggaa ggcttacctg   2520

agggtgtgcc attccgaaga ccatcgactt ttggcattcc gaggctggag aagatactca   2580

gaaacaaagc caaaattaag ttcatcatta aaaagcccga aatgtttgag acggcgatta   2640

aggagagcac ctcctctaag agccctccca gaaaaataaa ttcatcaccc aatgttaata   2700

ctactgcatc aggtgttgaa gaccttaaca tcattcaggt gacaattcca gatgatgata   2760

atgaaagact ctcgaaagtt gaaaaagcta gacagctaag agaacaagtg aatgacctct   2820

ttagtcggaa atttggtgaa gctattggta tgggttttcc tgtgaaagtt ccctacagga   2880

aaatcacaat taaccctggc tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca   2940

aagcccccag ctacctggaa atcagctcca tgagaaggat cttagactct gccgagttta   3000

tcaaattcac ggtcattaga ccatttccag gacttgtgat taataaccag ctggttgatc   3060

agagtgagtc agaaggcccc gtgatacaag aatcagctga accaagccag ttggaagttc   3120

cagccacaga agaaataaaa gagactgatg gaagctctca gatcaagcaa gaaccagacc   3180

ccacgtggta gacctcttcc ctcctaggag ccttgagtta cggtgtttat tttccaatca   3240

agtgaagata tctcctactt ctcctactgg aacatctcag cttctgcagt gaagaaaaat   3300

tcctgtgata gttcagttct ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat   3360

cctttgttca cggctctcct taatgactga gtgaacagtt cctatctgta tatttgacta   3420

aaccttttcc taagctatct ctcatggttc ctatgttttt ttatcataat taaaagcaaa   3480

accatctgga tcacctaaca gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa   3540

tacagagaga acctcttcca cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga   3600

agttgaagat cgggttgagg attggggcta gctcgatgac actaaggccc caacatcgcg   3660

ggacctgctg tggcgcggat tcttaggaac gctgttctag ccggccccct ctccaggggt   3720

cgccgtggcc ggcattattt cctagttctt cttgtaaccc tgaggtgcca gcgcggggag   3780

tgaggagggg tcagggggct aaggatgcaa cctctgacgt tctgcgcctt cctaggagag   3840

tcttacatgt gttgagattt cacaagcaat gcgagttgta aaataccagc tctacaagaa   3900

gctaggctct gtgacggcat agttttcagt agctttatca caatattcac aatggagaat   3960

tatatgacat ggtagcagaa ataggccctt ttatgtgttg cttctatttt acctcaaatt   4020

gtagatatag ggtaatcaat aaaatccatc catgcctttc acacactaag t            4071


<210>  5189
<211>  977
<212>  PRT
<213>  Homo sapiens

<400>  5189

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr 
                565                 570                 575


Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro 
            580                 585                 590


Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu 
        595                 600                 605


Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys 
    610                 615                 620


Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile 
625                 630                 635                 640


Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser 
                645                 650                 655


Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn 
            660                 665                 670


Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly 
        675                 680                 685


Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala 
    690                 695                 700


Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe 
705                 710                 715                 720


Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val 
                725                 730                 735


Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly 
            740                 745                 750


Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro 
        755                 760                 765


Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile 
    770                 775                 780


Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser 
785                 790                 795                 800


Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr 
                805                 810                 815


Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp 
            820                 825                 830


Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg 
        835                 840                 845


Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly 
    850                 855                 860


Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro 
865                 870                 875                 880


Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala 
                885                 890                 895


Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala 
            900                 905                 910


Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile 
        915                 920                 925


Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln 
    930                 935                 940


Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile 
945                 950                 955                 960


Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr 
                965                 970                 975


Trp 



<210>  5190
<211>  4978
<212>  DNA
<213>  Homo sapiens

<400>  5190
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1080

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1140

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1200

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1260

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1320

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1380

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1440

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1500

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1560

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1620

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1680

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1740

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1800

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1860

gaacgaatac accagctcaa gctcttggac tcaccgaggc agtaaaagta ccatatcctg   1920

tgtttgaatc aaacccggag ttcttgtatg tggaaggctt gccagagggg attcccttcc   1980

gaagccctac ctggtttgga attccacgac ttgaaaggat cgtccgcggg agtaataaaa   2040

tcaagttcgt tgttaaaaaa cctgaactag ttatttccta cttgcctcct gggatggcta   2100

gtaaaataaa cactaaagct ttgcagtccc ccaaaagacc acgaagtcct gggagtaatt   2160

caaaggttcc tgaaattgag gtcaccgtgg aaggccctaa taacaacaat cctcaaacct   2220

cagctgttcg aaccccgacc cagactaacg gttctaacgt tcccttcaag ccacgaggga   2280

gagagttttc ctttgaggcc tggaatgcca aaatcacgga cctaaaacag aaagttgaaa   2340

atctcttcaa tgagaaatgt ggggaagctc ttggccttaa acaagctgtg aaggtgccgt   2400

tcgcgttatt tgagtctttc ccggaagact tttatgtgga aggcttacct gagggtgtgc   2460

cattccgaag accatcgact tttggcattc cgaggctgga gaagatactc agaaacaaag   2520

ccaaaattaa gttcatcatt aaaaagcccg aaatgtttga gacggcgatt aaggagagca   2580

cctcctctaa gagccctccc agaaaaataa attcatcacc caatgttaat actactgcat   2640

caggtgttga agaccttaac atcattcagg tgacaattcc agatgatgat aatgaaagac   2700

tctcgaaagt tgaaaaagct agacagctaa gagaacaagt gaatgacctc tttagtcgga   2760

aatttggtga agctattggt atgggttttc ctgtgaaagt tccctacagg aaaatcacaa   2820

ttaaccctgg ctgtgtggtg gttgatggca tgcccccggg ggtgtccttc aaagccccca   2880

gctacctgga aatcagctcc atgagaagga tcttagactc tgccgagttt atcaaattca   2940

cggtcattag accatttcca ggacttgtga ttaataacca gctggttgat cagagtgagt   3000

cagaaggccc cgtgatacaa gaatcagctg aaccaagcca gttggaagtt ccagccacag   3060

aagaaataaa agagactgat ggaagctctc agatcaagca agaaccagac cccacgtggt   3120

agacctcttc cctcctaggg taaatcagct tctgtgtcag ggatgctgtg tggtgtccat   3180

ctgaaccccc tgcatacgcg tagctaatgt gatctcccca ctttcacata agatggtggc   3240

cctgccttca gggaatgtgg gagccaggtg ggagccttcc cggatattta agctagaaga   3300

ttctacaggg agattctcct tggatcaata tatgtctctc agtcaaagat gtaaaagcac   3360

ttttgcctta aaaagaatgt tctgtttcta aatagagtca acgttgtcct cctcattgga   3420

attcactatg agtcagaatc attagactga cttttttttt tccatagtaa tagtattttg   3480

cagagtctca cagagctgca gatcttttgt tcatcttgca gagttaacaa gtctgatcct   3540

gttagtccag atttcttaaa tttggccaag ttataatagg agcagtagct tgagacccga   3600

agtcaggaaa ctttgacaat ggattttttt ttttaatcca gagacttgta ctggaatttg   3660

ccttaccctg tcagctcatg gacttaaggt ttcatcccgc tttatgagtg cttctgaatc   3720

caagtcattg ttacctgaat ttgcaaatta agttgtgata ttcgtgactg ttaaattcct   3780

gtaattagat taacctcttt gcttgcttgt ttgttttctc tcctatttta gcttaaagta   3840

tcagtggttg agaagagctt ttcggacctg ttactacccc aagctgtgta atatacttgt   3900

ataacagaaa taccttctat acaaaccttt ttttctactt ttagatagaa atgtctactt   3960

tttcagcagt tctgtgaatt aaagagcaga gtgactgtgg gtctggaatg gctggtgtac   4020

ttgggaatgt actatcagga ttttacagca atgctgggaa atgacaggga aaatgacagg   4080

aatgaatctc accagatttt ttatgtactc agcagagcct tgagttacgg tgtttatttt   4140

ccaatcaagt gaagatatct cctacttctc ctactggaac atctcagctt ctgcagtgaa   4200

gaaaaattcc tgtgatagtt cagttcttta gtttttctat ttgaaaaaaa aaaatcattt   4260

aaatgatcct ttgttcacgg ctctccttaa tgactgagtg aacagttcct atctgtatat   4320

ttgactaaac cttttcctaa gctatctctc atggttccta tgttttttta tcataattaa   4380

aagcaaaacc atctggatca cctaacagtc agaggtcagt atctcagcgt gtgaattata   4440

gaggaaatac agagagaacc tcttccactt ttacttttcg tccaaataaa atgcatggtg   4500

taccagaagt tgaagatcgg gttgaggatt ggggctagct cgatgacact aaggccccaa   4560

catcgcggga cctgctgtgg cgcggattct taggaacgct gttctagccg gccccctctc   4620

caggggtcgc cgtggccggc attatttcct agttcttctt gtaaccctga ggtgccagcg   4680

cggggagtga ggaggggtca gggggctaag gatgcaacct ctgacgttct gcgccttcct   4740

aggagagtct tacatgtgtt gagatttcac aagcaatgcg agttgtaaaa taccagctct   4800

acaagaagct aggctctgtg acggcatagt tttcagtagc tttatcacaa tattcacaat   4860

ggagaattat atgacatggt agcagaaata ggccctttta tgtgttgctt ctattttacc   4920

tcaaattgta gatatagggt aatcaataaa atccatccat gcctttcaca cactaagt     4978


<210>  5191
<211>  954
<212>  PRT
<213>  Homo sapiens

<400>  5191

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly 
    530                 535                 540


Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro 
545                 550                 555                 560


Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser 
                565                 570                 575


Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser 
            580                 585                 590


Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr 
        595                 600                 605


Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser 
    610                 615                 620


Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile 
625                 630                 635                 640


Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala 
                645                 650                 655


Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro 
            660                 665                 670


Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp 
        675                 680                 685


Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala 
    690                 695                 700


Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser 
705                 710                 715                 720


Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe 
                725                 730                 735


Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg 
            740                 745                 750


Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu 
        755                 760                 765


Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile 
    770                 775                 780


Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu 
785                 790                 795                 800


Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser 
                805                 810                 815


Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe 
            820                 825                 830


Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val 
        835                 840                 845


Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly 
    850                 855                 860


Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser 
865                 870                 875                 880


Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val 
                885                 890                 895


Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln 
            900                 905                 910


Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln 
        915                 920                 925


Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser 
    930                 935                 940


Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950


<210>  5192
<211>  4987
<212>  DNA
<213>  Homo sapiens

<400>  5192
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1080

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1140

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1200

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1260

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1320

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1380

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1440

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1500

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1560

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1620

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1680

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1740

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1800

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1860

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1920

catatcctgt gtttgaatca aacccggagt tcttgtatgt ggaaggcttg ccagagggga   1980

ttcccttccg aagccctacc tggtttggaa ttccacgact tgaaaggatc gtccgcggga   2040

gtaataaaat caagttcgtt gttaaaaaac ctgaactagt tatttcctac ttgcctcctg   2100

ggatggctag taaaataaac actaaagctt tgcagtcccc caaaagacca cgaagtcctg   2160

ggagtaattc aaaggttcct gaaattgagg tcaccgtgga aggccctaat aacaacaatc   2220

ctcaaacctc agctgttcga accccgaccc agactaacgg ttctaacgtt cccttcaagc   2280

cacgagggag agagttttcc tttgaggcct ggaatgccaa aatcacggac ctaaaacaga   2340

aagttgaaaa tctcttcaat gagaaatgtg gggaagctct tggccttaaa caagctgtga   2400

aggtgccgtt cgcgttattt gagtctttcc cggaagactt ttatgtggaa ggcttacctg   2460

agggtgtgcc attccgaaga ccatcgactt ttggcattcc gaggctggag aagatactca   2520

gaaacaaagc caaaattaag ttcatcatta aaaagcccga aatgtttgag acggcgatta   2580

aggagagcac ctcctctaag agccctccca gaaaaataaa ttcatcaccc aatgttaata   2640

ctactgcatc aggtgttgaa gaccttaaca tcattcaggt gacaattcca gatgatgata   2700

atgaaagact ctcgaaagtt gaaaaagcta gacagctaag agaacaagtg aatgacctct   2760

ttagtcggaa atttggtgaa gctattggta tgggttttcc tgtgaaagtt ccctacagga   2820

aaatcacaat taaccctggc tgtgtggtgg ttgatggcat gcccccgggg gtgtccttca   2880

aagcccccag ctacctggaa atcagctcca tgagaaggat cttagactct gccgagttta   2940

tcaaattcac ggtcattaga ccatttccag gacttgtgat taataaccag ctggttgatc   3000

agagtgagtc agaaggcccc gtgatacaag aatcagctga accaagccag ttggaagttc   3060

cagccacaga agaaataaaa gagactgatg gaagctctca gatcaagcaa gaaccagacc   3120

ccacgtggta gacctcttcc ctcctagggt aaatcagctt ctgtgtcagg gatgctgtgt   3180

ggtgtccatc tgaaccccct gcatacgcgt agctaatgtg atctccccac tttcacataa   3240

gatggtggcc ctgccttcag ggaatgtggg agccaggtgg gagccttccc ggatatttaa   3300

gctagaagat tctacaggga gattctcctt ggatcaatat atgtctctca gtcaaagatg   3360

taaaagcact tttgccttaa aaagaatgtt ctgtttctaa atagagtcaa cgttgtcctc   3420

ctcattggaa ttcactatga gtcagaatca ttagactgac tttttttttt ccatagtaat   3480

agtattttgc agagtctcac agagctgcag atcttttgtt catcttgcag agttaacaag   3540

tctgatcctg ttagtccaga tttcttaaat ttggccaagt tataatagga gcagtagctt   3600

gagacccgaa gtcaggaaac tttgacaatg gatttttttt tttaatccag agacttgtac   3660

tggaatttgc cttaccctgt cagctcatgg acttaaggtt tcatcccgct ttatgagtgc   3720

ttctgaatcc aagtcattgt tacctgaatt tgcaaattaa gttgtgatat tcgtgactgt   3780

taaattcctg taattagatt aacctctttg cttgcttgtt tgttttctct cctattttag   3840

cttaaagtat cagtggttga gaagagcttt tcggacctgt tactacccca agctgtgtaa   3900

tatacttgta taacagaaat accttctata caaacctttt tttctacttt tagatagaaa   3960

tgtctacttt ttcagcagtt ctgtgaatta aagagcagag tgactgtggg tctggaatgg   4020

ctggtgtact tgggaatgta ctatcaggat tttacagcaa tgctgggaaa tgacagggaa   4080

aatgacagga atgaatctca ccagattttt tatgtactca gcagagcctt gagttacggt   4140

gtttattttc caatcaagtg aagatatctc ctacttctcc tactggaaca tctcagcttc   4200

tgcagtgaag aaaaattcct gtgatagttc agttctttag tttttctatt tgaaaaaaaa   4260

aaatcattta aatgatcctt tgttcacggc tctccttaat gactgagtga acagttccta   4320

tctgtatatt tgactaaacc ttttcctaag ctatctctca tggttcctat gtttttttat   4380

cataattaaa agcaaaacca tctggatcac ctaacagtca gaggtcagta tctcagcgtg   4440

tgaattatag aggaaataca gagagaacct cttccacttt tacttttcgt ccaaataaaa   4500

tgcatggtgt accagaagtt gaagatcggg ttgaggattg gggctagctc gatgacacta   4560

aggccccaac atcgcgggac ctgctgtggc gcggattctt aggaacgctg ttctagccgg   4620

ccccctctcc aggggtcgcc gtggccggca ttatttccta gttcttcttg taaccctgag   4680

gtgccagcgc ggggagtgag gaggggtcag ggggctaagg atgcaacctc tgacgttctg   4740

cgccttccta ggagagtctt acatgtgttg agatttcaca agcaatgcga gttgtaaaat   4800

accagctcta caagaagcta ggctctgtga cggcatagtt ttcagtagct ttatcacaat   4860

attcacaatg gagaattata tgacatggta gcagaaatag gcccttttat gtgttgcttc   4920

tattttacct caaattgtag atatagggta atcaataaaa tccatccatg cctttcacac   4980

actaagt                                                             4987


<210>  5193
<211>  957
<212>  PRT
<213>  Homo sapiens

<400>  5193

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro 
                565                 570                 575


Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu Arg Ile Val 
            580                 585                 590


Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro Glu Leu Val 
        595                 600                 605


Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn Thr Lys Ala 
    610                 615                 620


Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn Ser Lys Val 
625                 630                 635                 640


Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn Asn Pro Gln 
                645                 650                 655


Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser Asn Val Pro 
            660                 665                 670


Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp Asn Ala Lys 
        675                 680                 685


Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn Glu Lys Cys 
    690                 695                 700


Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro Phe Ala Leu 
705                 710                 715                 720


Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu Pro Glu Gly 
                725                 730                 735


Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg Leu Glu Lys 
            740                 745                 750


Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys Lys Pro Glu 
        755                 760                 765


Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys Ser Pro Pro 
    770                 775                 780


Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala Ser Gly Val 
785                 790                 795                 800


Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp Asp Asn Glu 
                805                 810                 815


Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu Gln Val Asn 
            820                 825                 830


Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met Gly Phe Pro 
        835                 840                 845


Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly Cys Val Val 
    850                 855                 860


Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro Ser Tyr Leu 
865                 870                 875                 880


Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu Phe Ile Lys 
                885                 890                 895


Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn Asn Gln Leu 
            900                 905                 910


Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu Ser Ala Glu 
        915                 920                 925


Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys Glu Thr Asp 
    930                 935                 940


Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
945                 950                 955


<210>  5194
<211>  7168
<212>  DNA
<213>  Homo sapiens

<400>  5194
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1080

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1140

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1200

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1260

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1320

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1380

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1440

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1500

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1560

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1620

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1680

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1740

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1800

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1860

aagagatttt taatttgaaa tttgcttaga tttgttgaca gcggtttcct ggagtgctgt   1920

cttgagaacg attctgagga ggctcagcaa gaaagagtgt ttcagttgat tgggtgtgtc   1980

tgtcatggag aaggaactca agctcttgga ctcaccgagg cagtaaaagt accatatcct   2040

gtgtttgaat caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc   2100

cgaagcccta cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa   2160

atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct   2220

agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat   2280

tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc   2340

tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg   2400

agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa   2460

aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg   2520

ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg   2580

ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa   2640

gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc   2700

acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca   2760

tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga   2820

ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg   2880

aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca   2940

attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt caaagccccc   3000

agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc   3060

acggtcatta ggtaagtgag agtttcctgc ttagtcacag gagcgaatct ggagctcatg   3120

aggctgactc ttctaaaatg cagccacagg tagtcatcga atccggcttc ctatgctgtg   3180

caatcaacaa atcaaaataa cttgtgtcat cattagaatg tcagatgtgc ttctacgaac   3240

taagctgact cttttaattc tttggcaaag ggttggcaaa ctaggactgt ttgccaaatt   3300

caggctgcct cctattttta gagtcttcct gaaacacagc tacacccgta ttatccatgg   3360

ctgctttcct gtcacagtga gtaagtagct gggactgaga aggcatggcc tccaaagtct   3420

aaaatattta ctctctagca ctttgtagaa aaaccttagc taggcacagt ggctaacgcc   3480

tgtaatccca gcattttggg aggccaaggc aggcagatca cctgaggtca ggagttccag   3540

accagcctgg ccaacatggt gaaatcccat ctctacaaaa ataaaacagt tagctgggca   3600

tgatggcggg tgcctgtaat cccagctact cgggaggctg aggcaggata gtcgcttgaa   3660

cccaggaggt ggaggttgca atgagccaag atcatgccac tgcactccag cctggacgac   3720

agagtgagac tccatcacaa gaaaaaaaga actttgtcaa cctctgtctt agggcgcctt   3780

gtcacaggct tcgggtcaga cggattcaac cttgcatcag ccatttgtta gccaggtcac   3840

tctgttcttt gtctgtaaat gagattgatc gttgttccca ctgagagtgt cagctccttc   3900

ccgtagagca ggcatgatga ttgtactcac ctctgacacc attgtgagtg ccacattcct   3960

tcccacgtcc ttgtcactgt aagagatgcc cacctgagca ccaaccccag gttatcttcc   4020

cctttgtctt ccagcccccc agaaacagct acgactcaac ctacccaatc atttcatcat   4080

cagattgcca ctgtctctag ttcaggtctc ttgggactgg cactcagaaa tctcataata   4140

aatcctcttg aggcttctca tacactcgtc ttcttccaat cttctttccc tcaaaatctc   4200

atattttggt tccacttcac ccaccgtcat tctccatatc actcccagga gttaggcaaa   4260

aagccccttc cgttcttccg tatgttaaac ttagaatcac tctgttccct gctctgcgtt   4320

tctatttttt gtttttcctc catttactag tagcttaaca ctttctaaca gtgttcttat   4380

tattgatacg tatctatctc ttccataagc ttataaggtc acggataata cttctcattg   4440

tagtacgtaa atgacgtggg ctagatatga gttgaataaa cagttatacc tgtaaattct   4500

tacagagtga aaataaattg ttatacttta caatttgttt ctctctttag accatttcca   4560

ggacttgtga ttaataaccg tgagtatttt gtgaagtgtt ttgtttttgt tttttcctgg   4620

ggtctgacgt gtgtgcgtgt gagtgtgtat acatgcttaa cgtatatcac gttacttcac   4680

ctatgtcagt aaccaggcca aatacttgtt ttagccctca gtaaaaacac caggcacttc   4740

ctagttgtaa aattattcaa gcttcttaac ttcctatcct cgatgcactt aatcataaaa   4800

tggtaataat agcaccgatt ttgggggagt cgttccagta gatggaaagc atctggaaca   4860

ggtgtcagca agctcctgcc gacgtgtatg cataaagttt tattgaaacc accatcgtgt   4920

ccatttgttt atggcagaac tgagagatgg cagcagcaag tgtgtgcctg caaaacctaa   4980

aatatttact aattggctct gcaagaaaag agtttgcatc cccctaacct agaacagtgt   5040

ctagcctcta gtatgtgttt agcctacagt atgtgctcag cgaatacaat ctatatttat   5100

tactgctttt atgactgtta taattactgt gcttggattt cgttacaaag taagtcacaa   5160

tgtgcctgct tctgttagta tttcagcaca gtgcctggca cacatggggc tctcaaatat   5220

tgctgagcga gtgaacaaat gtcctttcaa ttccttaacg ttgatgtcat tttcaatagt   5280

attttgagcc aaacttaatt ttgcgagtgt gttttgtttt cttaacttta ttattaaaaa   5340

tgtataaaag tgaggccagg cgtggtggct cacgcctgta atcccagcag tttgggaggc   5400

tgaggcaggc ggatcagttg aggttgggag ttggagacca gcccgtccaa catggtgaaa   5460

gcctgtctct actaaaaata caaaaatcag ctgggtgtgg tggcgcgtgc ctgtaatccc   5520

agctactcag gaggctgagg caggagagtt gcttgaatcc tagaggtgga ggttgcagtg   5580

agctgagatc gtgccattgc actccagcct gggcaacaag agcaaaactc tgtcccaata   5640

aataaataaa taaaatgttc tcttttgttc ctgttcttgt gcggtagtgt ggtatagagt   5700

tttatggtaa ttactgtgaa ttagtgattc tgagggacat atcagaactc tgaggtttgt   5760

ttccttctca tcttgaggga aacagcaaat gtatgttaaa atgcttttcc aagggaacaa   5820

cacatcctta cattatttaa accaatctgc ttcattttca gagctggttg atcagagtga   5880

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   5940

agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag accccacgtg   6000

gtagacctct tccctcctag gcttaaagta tcagtggttg agaagagctt ttcggacctg   6060

ttactacccc aagctgtgta atatacttgt ataacagaaa taccttctat acaaaccttt   6120

ttttctactt ttagatagaa atgtctactt tttcagcagt tctgtgaatt aaagagcaga   6180

gtgactgtgg gtctggaatg gctggtgtac ttgggaatgt actatcagga ttttacagca   6240

atgctgggaa atgacaggga aaatgacagg aatgaatctc accagatttt ttatgtactc   6300

agcagagcct tgagttacgg tgtttatttt ccaatcaagt gaagatatct cctacttctc   6360

ctactggaac atctcagctt ctgcagtgaa gaaaaattcc tgtgatagtt cagttcttta   6420

gtttttctat ttgaaaaaaa aaaatcattt aaatgatcct ttgttcacgg ctctccttaa   6480

tgactgagtg aacagttcct atctgtatat ttgactaaac cttttcctaa gctatctctc   6540

atggttccta tgttttttta tcataattaa aagcaaaacc atctggatca cctaacagtc   6600

agaggtcagt atctcagcgt gtgaattata gaggaaatac agagagaacc tcttccactt   6660

ttacttttcg tccaaataaa atgcatggtg taccagaagt tgaagatcgg gttgaggatt   6720

ggggctagct cgatgacact aaggccccaa catcgcggga cctgctgtgg cgcggattct   6780

taggaacgct gttctagccg gccccctctc caggggtcgc cgtggccggc attatttcct   6840

agttcttctt gtaaccctga ggtgccagcg cggggagtga ggaggggtca gggggctaag   6900

gatgcaacct ctgacgttct gcgccttcct aggagagtct tacatgtgtt gagatttcac   6960

aagcaatgcg agttgtaaaa taccagctct acaagaagct aggctctgtg acggcatagt   7020

tttcagtagc tttatcacaa tattcacaat ggagaattat atgacatggt agcagaaata   7080

ggccctttta tgtgttgctt ctattttacc tcaaattgta gatatagggt aatcaataaa   7140

atccatccat gcctttcaca cactaagt                                      7168


<210>  5195
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  5195

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535                 540


<210>  5196
<211>  3656
<212>  DNA
<213>  Homo sapiens

<400>  5196
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag    960

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1020

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1080

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1140

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1200

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1260

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1320

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1380

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1440

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1500

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1560

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1620

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1680

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1740

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagctc   1800

aagctcttgg actcaccgag gcagtaaaag taccatatcc tgtgtttgaa tcaaacccgg   1860

agttcttgta tgtggaaggc ttgccagagg ggattccctt ccgaagccct acctggtttg   1920

gaattccacg acttgaaagg atcgtccgcg ggagtaataa aatcaagttc gttgttaaaa   1980

aacctgaact agttatttcc tacttgcctc ctgggatggc tagtaaaata aacactaaag   2040

ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa ttcaaaggtt cctgaaattg   2100

aggtcaccgt ggaaggccct aataacaaca atcctcaaac ctcagctgtt cgaaccccga   2160

cccagactaa cggttctaac gttcccttca agccacgagg gagagagttt tcctttgagg   2220

cctggaatgc caaaatcacg gacctaaaac agaaagttga aaatctcttc aatgagaaat   2280

gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc gttcgcgtta tttgagtctt   2340

tcccggaaga cttttatgtg gaaggcttac ctgagggtgt gccattccga agaccatcga   2400

cttttggcat tccgaggctg gagaagatac tcagaaacaa agccaaaatt aagttcatca   2460

ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag cacctcctct aagagccctc   2520

ccagaaaaat aaattcatca cccaatgtta atactactgc atcaggtgtt gaagacctta   2580

acatcattca ggtgacaatt ccagatgatg ataatgaaag actctcgaaa gttgaaaaag   2640

ctagacagct aagagaacaa gtgaatgacc tctttagtcg gaaatttggt gaagctattg   2700

gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac aattaaccct ggctgtgtgg   2760

tggttgatgg catgcccccg ggggtgtcct tcaaagcccc cagctacctg gaaatcagct   2820

ccatgagaag gatcttagac tctgccgagt ttatcaaatt cacggtcatt agaccatttc   2880

caggacttgt gattaataac cagctggttg atcagagtga gtcagaaggc cccgtgatac   2940

aagaatcagc tgaaccaagc cagttggaag ttccagccac agaagaaata aaagagactg   3000

atggaagctc tcagatcaag caagaaccag accccacgtg gtagacctct tccctcctag   3060

gcaaaaccat ctggatcacc taacagtcag aggtcagtat ctcagcgtgt gaattataga   3120

ggaaatacag agagaacctc ttccactttt acttttcgtc caaataaaat gcatggtgta   3180

ccagaagttg aagatcgggt tgaggattgg ggctagctcg atgacactaa ggccccaaca   3240

tcgcgggacc tgctgtggcg cggattctta ggaacgctgt tctagccggc cccctctcca   3300

ggggtcgccg tggccggcat tatttcctag ttcttcttgt aaccctgagg tgccagcgcg   3360

gggagtgagg aggggtcagg gggctaagga tgcaacctct gacgttctgc gccttcctag   3420

gagagtctta catgtgttga gatttcacaa gcaatgcgag ttgtaaaata ccagctctac   3480

aagaagctag gctctgtgac ggcatagttt tcagtagctt tatcacaata ttcacaatgg   3540

agaattatat gacatggtag cagaaatagg cccttttatg tgttgcttct attttacctc   3600

aaattgtaga tatagggtaa tcaataaaat ccatccatgc ctttcacaca ctaagt       3656


<210>  5197
<211>  928
<212>  PRT
<213>  Homo sapiens

<400>  5197

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro 
        515                 520                 525


Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu Pro Glu 
    530                 535                 540


Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg Leu Glu 
545                 550                 555                 560


Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys Lys Pro 
                565                 570                 575


Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys Ile Asn 
            580                 585                 590


Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly Ser Asn 
        595                 600                 605


Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn Asn Asn 
    610                 615                 620


Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn Gly Ser 
625                 630                 635                 640


Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu Ala Trp 
                645                 650                 655


Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu Phe Asn 
            660                 665                 670


Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys Val Pro 
        675                 680                 685


Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu Gly Leu 
    690                 695                 700


Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile Pro Arg 
705                 710                 715                 720


Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile Ile Lys 
                725                 730                 735


Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser Ser Lys 
            740                 745                 750


Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr Thr Ala 
        755                 760                 765


Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro Asp Asp 
    770                 775                 780


Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu Arg Glu 
785                 790                 795                 800


Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile Gly Met 
                805                 810                 815


Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn Pro Gly 
            820                 825                 830


Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys Ala Pro 
        835                 840                 845


Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser Ala Glu 
    850                 855                 860


Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro Gly Leu Val Ile Asn 
865                 870                 875                 880


Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly Pro Val Ile Gln Glu 
                885                 890                 895


Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala Thr Glu Glu Ile Lys 
            900                 905                 910


Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu Pro Asp Pro Thr Trp 
        915                 920                 925


<210>  5198
<211>  4351
<212>  DNA
<213>  Homo sapiens

<400>  5198
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040

taccatatcc tgtgtttgaa tcaaacccgg agttcttgaa aggatcgtcc gcgggagtaa   2100

taaaatcaag ttcgttgtta aaaaacctga actagttatt tcctacttgc ctcctgggat   2160

ggctagtaaa ataaacacta aagctttgca gtcccccaaa agaccacgaa gtcctgggag   2220

taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc cctaataaca acaatcctca   2280

aacctcagct gttcgaaccc cgacccagac taacggttct aacgttccct tcaagccacg   2340

agggagagag ttttcctttg aggcctggaa tgccaaaatc acggacctaa aacagaaagt   2400

tgaaaatctc ttcaatgaga aatgtgggga agctcttggc cttaaacaag ctgtgaaggt   2460

gccgttcgcg ttatttgagt ctttcccgga agacttttat gtggaaggct tacctgaggg   2520

tgtgccattc cgaagaccat cgacttttgg cattccgagg ctggagaaga tactcagaaa   2580

caaagccaaa attaagttca tcattaaaaa gcccgaaatg tttgagacgg cgattaagga   2640

gagcacctcc tctaagagcc ctcccagaaa aataaattca tcacccaatg ttaatactac   2700

tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca attccagatg atgataatga   2760

aagactctcg aaagttgaaa aagctagaca gctaagagaa caagtgaatg acctctttag   2820

tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg aaagttccct acaggaaaat   2880

cacaattaac cctggctgtg tggtggttga tggcatgccc ccgggggtgt ccttcaaagc   2940

ccccagctac ctggaaatca gctccatgag aaggatctta gactctgccg agtttatcaa   3000

attcacggtc attagaccat ttccaggact tgtgattaat aaccagctgg ttgatcagag   3060

tgagtcagaa ggccccgtga tacaagaatc agctgaacca agccagttgg aagttccagc   3120

cacagaagaa ataaaagaga ctgatggaag ctctcagatc aagcaagaac cagaccccac   3180

gtggtagacc tcttccctcc taggcttaaa gtatcagtgg ttgagaagag cttttcggac   3240

ctgttactac cccaagctgt gtaatatact tgtataacag aaataccttc tatacaaacc   3300

tttttttcta cttttagata gaaatgtcta ctttttcagc agttctgtga attaaagagc   3360

agagtgactg tgggtctgga atggctggtg tacttgggaa tgtactatca ggattttaca   3420

gcaatgctgg gaaatgacag ggaaaatgac aggaatgaat ctcaccagat tttttatgta   3480

ctcagcagag ccttgagtta cggtgtttat tttccaatca agtgaagata tctcctactt   3540

ctcctactgg aacatctcag cttctgcagt gaagaaaaat tcctgtgata gttcagttct   3600

ttagtttttc tatttgaaaa aaaaaaatca tttaaatgat cctttgttca cggctctcct   3660

taatgactga gtgaacagtt cctatctgta tatttgacta aaccttttcc taagctatct   3720

ctcatggttc ctatgttttt ttatcataat taaaagcaaa accatctgga tcacctaaca   3780

gtcagaggtc agtatctcag cgtgtgaatt atagaggaaa tacagagaga acctcttcca   3840

cttttacttt tcgtccaaat aaaatgcatg gtgtaccaga agttgaagat cgggttgagg   3900

attggggcta gctcgatgac actaaggccc caacatcgcg ggacctgctg tggcgcggat   3960

tcttaggaac gctgttctag ccggccccct ctccaggggt cgccgtggcc ggcattattt   4020

cctagttctt cttgtaaccc tgaggtgcca gcgcggggag tgaggagggg tcagggggct   4080

aaggatgcaa cctctgacgt tctgcgcctt cctaggagag tcttacatgt gttgagattt   4140

cacaagcaat gcgagttgta aaataccagc tctacaagaa gctaggctct gtgacggcat   4200

agttttcagt agctttatca caatattcac aatggagaat tatatgacat ggtagcagaa   4260

ataggccctt ttatgtgttg cttctatttt acctcaaatt gtagatatag ggtaatcaat   4320

aaaatccatc catgcctttc acacactaag t                                  4351


<210>  5199
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  5199

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys 
        595                 600                 605


Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu 
    610                 615                 620


Asn 
625


<210>  5200
<211>  7112
<212>  DNA
<213>  Homo sapiens

<400>  5200
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040

taccatatcc tgtgtttgaa tcaaacccgg agttcttgaa aggatcgtcc gcgggagtaa   2100

taaaatcaag ttcgttgtta aaaaacctga actagttatt tcctacttgc ctcctgggat   2160

ggctagtaaa ataaacacta aagctttgca gtcccccaaa agaccacgaa gtcctgggag   2220

taattcaaag gttcctgaaa ttgaggtcac cgtggaaggc cctaataaca acaatcctca   2280

aacctcagct gttcgaaccc cgacccagac taacggttct aacgttccct tcaagccacg   2340

agggagagag ttttcctttg aggcctggaa tgccaaaatc acggacctaa aacagaaagt   2400

tgaaaatctc ttcaatgaga aatgtgggga agctcttggc cttaaacaag ctgtgaaggt   2460

gccgttcgcg ttatttgagt ctttcccgga agacttttat gtggaaggct tacctgaggg   2520

tgtgccattc cgaagaccat cgacttttgg cattccgagg ctggagaaga tactcagaaa   2580

caaagccaaa attaagttca tcattaaaaa gcccgaaatg tttgagacgg cgattaagga   2640

gagcacctcc tctaagagcc ctcccagaaa aataaattca tcacccaatg ttaatactac   2700

tgcatcaggt gttgaagacc ttaacatcat tcaggtgaca attccagatg atgataatga   2760

aagactctcg aaagttgaaa aagctagaca gctaagagaa caagtgaatg acctctttag   2820

tcggaaattt ggtgaagcta ttggtatggg ttttcctgtg aaagttccct acaggaaaat   2880

cacaattaac cctggctgtg tggtggttga tggcatgccc ccgggggtgt ccttcaaagc   2940

ccccagctac ctggaaatca gctccatgag aaggatctta gactctgccg agtttatcaa   3000

attcacggtc attaggtaag tgagagtttc ctgcttagtc acaggagcga atctggagct   3060

catgaggctg actcttctaa aatgcagcca caggtagtca tcgaatccgg cttcctatgc   3120

tgtgcaatca acaaatcaaa ataacttgtg tcatcattag aatgtcagat gtgcttctac   3180

gaactaagct gactctttta attctttggc aaagggttgg caaactagga ctgtttgcca   3240

aattcaggct gcctcctatt tttagagtct tcctgaaaca cagctacacc cgtattatcc   3300

atggctgctt tcctgtcaca gtgagtaagt agctgggact gagaaggcat ggcctccaaa   3360

gtctaaaata tttactctct agcactttgt agaaaaacct tagctaggca cagtggctaa   3420

cgcctgtaat cccagcattt tgggaggcca aggcaggcag atcacctgag gtcaggagtt   3480

ccagaccagc ctggccaaca tggtgaaatc ccatctctac aaaaataaaa cagttagctg   3540

ggcatgatgg cgggtgcctg taatcccagc tactcgggag gctgaggcag gatagtcgct   3600

tgaacccagg aggtggaggt tgcaatgagc caagatcatg ccactgcact ccagcctgga   3660

cgacagagtg agactccatc acaagaaaaa aagaactttg tcaacctctg tcttagggcg   3720

ccttgtcaca ggcttcgggt cagacggatt caaccttgca tcagccattt gttagccagg   3780

tcactctgtt ctttgtctgt aaatgagatt gatcgttgtt cccactgaga gtgtcagctc   3840

cttcccgtag agcaggcatg atgattgtac tcacctctga caccattgtg agtgccacat   3900

tccttcccac gtccttgtca ctgtaagaga tgcccacctg agcaccaacc ccaggttatc   3960

ttcccctttg tcttccagcc ccccagaaac agctacgact caacctaccc aatcatttca   4020

tcatcagatt gccactgtct ctagttcagg tctcttggga ctggcactca gaaatctcat   4080

aataaatcct cttgaggctt ctcatacact cgtcttcttc caatcttctt tccctcaaaa   4140

tctcatattt tggttccact tcacccaccg tcattctcca tatcactccc aggagttagg   4200

caaaaagccc cttccgttct tccgtatgtt aaacttagaa tcactctgtt ccctgctctg   4260

cgtttctatt ttttgttttt cctccattta ctagtagctt aacactttct aacagtgttc   4320

ttattattga tacgtatcta tctcttccat aagcttataa ggtcacggat aatacttctc   4380

attgtagtac gtaaatgacg tgggctagat atgagttgaa taaacagtta tacctgtaaa   4440

ttcttacaga gtgaaaataa attgttatac tttacaattt gtttctctct ttagaccatt   4500

tccaggactt gtgattaata accgtgagta ttttgtgaag tgttttgttt ttgttttttc   4560

ctggggtctg acgtgtgtgc gtgtgagtgt gtatacatgc ttaacgtata tcacgttact   4620

tcacctatgt cagtaaccag gccaaatact tgttttagcc ctcagtaaaa acaccaggca   4680

cttcctagtt gtaaaattat tcaagcttct taacttccta tcctcgatgc acttaatcat   4740

aaaatggtaa taatagcacc gattttgggg gagtcgttcc agtagatgga aagcatctgg   4800

aacaggtgtc agcaagctcc tgccgacgtg tatgcataaa gttttattga aaccaccatc   4860

gtgtccattt gtttatggca gaactgagag atggcagcag caagtgtgtg cctgcaaaac   4920

ctaaaatatt tactaattgg ctctgcaaga aaagagtttg catcccccta acctagaaca   4980

gtgtctagcc tctagtatgt gtttagccta cagtatgtgc tcagcgaata caatctatat   5040

ttattactgc ttttatgact gttataatta ctgtgcttgg atttcgttac aaagtaagtc   5100

acaatgtgcc tgcttctgtt agtatttcag cacagtgcct ggcacacatg gggctctcaa   5160

atattgctga gcgagtgaac aaatgtcctt tcaattcctt aacgttgatg tcattttcaa   5220

tagtattttg agccaaactt aattttgcga gtgtgttttg ttttcttaac tttattatta   5280

aaaatgtata aaagtgaggc caggcgtggt ggctcacgcc tgtaatccca gcagtttggg   5340

aggctgaggc aggcggatca gttgaggttg ggagttggag accagcccgt ccaacatggt   5400

gaaagcctgt ctctactaaa aatacaaaaa tcagctgggt gtggtggcgc gtgcctgtaa   5460

tcccagctac tcaggaggct gaggcaggag agttgcttga atcctagagg tggaggttgc   5520

agtgagctga gatcgtgcca ttgcactcca gcctgggcaa caagagcaaa actctgtccc   5580

aataaataaa taaataaaat gttctctttt gttcctgttc ttgtgcggta gtgtggtata   5640

gagttttatg gtaattactg tgaattagtg attctgaggg acatatcaga actctgaggt   5700

ttgtttcctt ctcatcttga gggaaacagc aaatgtatgt taaaatgctt ttccaaggga   5760

acaacacatc cttacattat ttaaaccaat ctgcttcatt ttcagagctg gttgatcaga   5820

gtgagtcaga aggccccgtg atacaagaat cagctgaacc aagccagttg gaagttccag   5880

ccacagaaga aataaaagag actgatggaa gctctcagat caagcaagaa ccagacccca   5940

cgtggtagac ctcttccctc ctaggcttaa agtatcagtg gttgagaaga gcttttcgga   6000

cctgttacta ccccaagctg tgtaatatac ttgtataaca gaaatacctt ctatacaaac   6060

ctttttttct acttttagat agaaatgtct actttttcag cagttctgtg aattaaagag   6120

cagagtgact gtgggtctgg aatggctggt gtacttggga atgtactatc aggattttac   6180

agcaatgctg ggaaatgaca gggaaaatga caggaatgaa tctcaccaga ttttttatgt   6240

actcagcaga gccttgagtt acggtgttta ttttccaatc aagtgaagat atctcctact   6300

tctcctactg gaacatctca gcttctgcag tgaagaaaaa ttcctgtgat agttcagttc   6360

tttagttttt ctatttgaaa aaaaaaaatc atttaaatga tcctttgttc acggctctcc   6420

ttaatgactg agtgaacagt tcctatctgt atatttgact aaaccttttc ctaagctatc   6480

tctcatggtt cctatgtttt tttatcataa ttaaaagcaa aaccatctgg atcacctaac   6540

agtcagaggt cagtatctca gcgtgtgaat tatagaggaa atacagagag aacctcttcc   6600

acttttactt ttcgtccaaa taaaatgcat ggtgtaccag aagttgaaga tcgggttgag   6660

gattggggct agctcgatga cactaaggcc ccaacatcgc gggacctgct gtggcgcgga   6720

ttcttaggaa cgctgttcta gccggccccc tctccagggg tcgccgtggc cggcattatt   6780

tcctagttct tcttgtaacc ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc   6840

taaggatgca acctctgacg ttctgcgcct tcctaggaga gtcttacatg tgttgagatt   6900

tcacaagcaa tgcgagttgt aaaataccag ctctacaaga agctaggctc tgtgacggca   6960

tagttttcag tagctttatc acaatattca caatggagaa ttatatgaca tggtagcaga   7020

aataggccct tttatgtgtt gcttctattt tacctcaaat tgtagatata gggtaatcaa   7080

taaaatccat ccatgccttt cacacactaa gt                                 7112


<210>  5201
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  5201

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Lys 
        595                 600                 605


Gly Ser Ser Ala Gly Val Ile Lys Ser Ser Ser Leu Leu Lys Asn Leu 
    610                 615                 620


Asn 
625


<210>  5202
<211>  4134
<212>  DNA
<213>  Homo sapiens

<400>  5202
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1140

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1200

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1260

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1320

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1380

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1440

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1500

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1560

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1620

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1680

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1740

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1800

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1860

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1920

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1980

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   2040

taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2100

ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2160

ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2220

ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2280

ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2340

atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2400

agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2460

agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2520

tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2580

ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2640

tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2700

ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2760

atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2820

ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2880

tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   2940

ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   3000

tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3060

ttatcaaatt cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg   3120

atcagagtga gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag   3180

ttccagccac agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag   3240

accccacgtg gtagacctct tccctcctag gagccttgag ttacggtgtt tattttccaa   3300

tcaagtgaag atatctccta cttctcctac tggaacatct cagcttctgc agtgaagaaa   3360

aattcctgtg atagttcagt tctttagttt ttctatttga aaaaaaaaaa tcatttaaat   3420

gatcctttgt tcacggctct ccttaatgac tgagtgaaca gttcctatct gtatatttga   3480

ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt tttttatcat aattaaaagc   3540

aaaaccatct ggatcaccta acagtcagag gtcagtatct cagcgtgtga attatagagg   3600

aaatacagag agaacctctt ccacttttac ttttcgtcca aataaaatgc atggtgtacc   3660

agaagttgaa gatcgggttg aggattgggg ctagctcgat gacactaagg ccccaacatc   3720

gcgggacctg ctgtggcgcg gattcttagg aacgctgttc tagccggccc cctctccagg   3780

ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa ccctgaggtg ccagcgcggg   3840

gagtgaggag gggtcagggg gctaaggatg caacctctga cgttctgcgc cttcctagga   3900

gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc agctctacaa   3960

gaagctaggc tctgtgacgg catagttttc agtagcttta tcacaatatt cacaatggag   4020

aattatatga catggtagca gaaataggcc cttttatgtg ttgcttctat tttacctcaa   4080

attgtagata tagggtaatc aataaaatcc atccatgcct ttcacacact aagt         4134


<210>  5203
<211>  998
<212>  PRT
<213>  Homo sapiens

<400>  5203

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser 
    290                 295                 300


Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro 
305                 310                 315                 320


Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro 
                325                 330                 335


Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu 
            340                 345                 350


Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu 
        355                 360                 365


Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr 
    370                 375                 380


Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu 
385                 390                 395                 400


Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile 
                405                 410                 415


Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val 
            420                 425                 430


Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu 
        435                 440                 445


Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr 
    450                 455                 460


Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu 
465                 470                 475                 480


Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu 
                485                 490                 495


Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro 
            500                 505                 510


Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile 
        515                 520                 525


Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu 
    530                 535                 540


Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val 
545                 550                 555                 560


Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu 
                565                 570                 575


Glu Ile Phe Asn Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala 
            580                 585                 590


Val Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr 
        595                 600                 605


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe 
    610                 615                 620


Gly Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys 
625                 630                 635                 640


Phe Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly 
                645                 650                 655


Met Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro 
            660                 665                 670


Arg Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val 
        675                 680                 685


Glu Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro 
    690                 695                 700


Thr Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu 
705                 710                 715                 720


Phe Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys 
                725                 730                 735


Val Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys 
            740                 745                 750


Gln Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp 
        755                 760                 765


Phe Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser 
    770                 775                 780


Thr Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys 
785                 790                 795                 800


Ile Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys 
                805                 810                 815


Glu Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro 
            820                 825                 830


Asn Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln 
        835                 840                 845


Val Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys 
    850                 855                 860


Ala Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe 
865                 870                 875                 880


Gly Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys 
                885                 890                 895


Ile Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly 
            900                 905                 910


Val Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg 
        915                 920                 925


Ile Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe 
    930                 935                 940


Pro Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu 
945                 950                 955                 960


Gly Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro 
                965                 970                 975


Ala Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln 
            980                 985                 990


Glu Pro Asp Pro Thr Trp 
        995


<210>  5204
<211>  3944
<212>  DNA
<213>  Homo sapiens

<400>  5204
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1080

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1140

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1200

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1260

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1320

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1380

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1440

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1500

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1560

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1620

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1680

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1740

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1800

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1860

aagagatttt taatttgaaa tttgctcaag ctcttggact caccgaggca gtaaaagtac   1920

catatcctgt gtttgaatca aacccggagt tcttgaaagg atcgtccgcg ggagtaataa   1980

aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc ctgggatggc   2040

tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc ctgggagtaa   2100

ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca atcctcaaac   2160

ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca agccacgagg   2220

gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac agaaagttga   2280

aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg tgaaggtgcc   2340

gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac ctgagggtgt   2400

gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac tcagaaacaa   2460

agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga ttaaggagag   2520

cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta atactactgc   2580

atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg ataatgaaag   2640

actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc tctttagtcg   2700

gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca ggaaaatcac   2760

aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct tcaaagcccc   2820

cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt ttatcaaatt   2880

cacggtcatt agaccatttc caggacttgt gattaataac cagctggttg atcagagtga   2940

gtcagaaggc cccgtgatac aagaatcagc tgaaccaagc cagttggaag ttccagccac   3000

agaagaaata aaagagactg atggaagctc tcagatcaag caagaaccag accccacgtg   3060

gtagacctct tccctcctag gagccttgag ttacggtgtt tattttccaa tcaagtgaag   3120

atatctccta cttctcctac tggaacatct cagcttctgc agtgaagaaa aattcctgtg   3180

atagttcagt tctttagttt ttctatttga aaaaaaaaaa tcatttaaat gatcctttgt   3240

tcacggctct ccttaatgac tgagtgaaca gttcctatct gtatatttga ctaaaccttt   3300

tcctaagcta tctctcatgg ttcctatgtt tttttatcat aattaaaagc aaaaccatct   3360

ggatcaccta acagtcagag gtcagtatct cagcgtgtga attatagagg aaatacagag   3420

agaacctctt ccacttttac ttttcgtcca aataaaatgc atggtgtacc agaagttgaa   3480

gatcgggttg aggattgggg ctagctcgat gacactaagg ccccaacatc gcgggacctg   3540

ctgtggcgcg gattcttagg aacgctgttc tagccggccc cctctccagg ggtcgccgtg   3600

gccggcatta tttcctagtt cttcttgtaa ccctgaggtg ccagcgcggg gagtgaggag   3660

gggtcagggg gctaaggatg caacctctga cgttctgcgc cttcctagga gagtcttaca   3720

tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc agctctacaa gaagctaggc   3780

tctgtgacgg catagttttc agtagcttta tcacaatatt cacaatggag aattatatga   3840

catggtagca gaaataggcc cttttatgtg ttgcttctat tttacctcaa attgtagata   3900

tagggtaatc aataaaatcc atccatgcct ttcacacact aagt                    3944


<210>  5205
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  5205

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr 
        515                 520                 525


Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu Lys Phe Ala Gln 
    530                 535                 540


Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro Tyr Pro Val Phe Glu 
545                 550                 555                 560


Ser Asn Pro Glu Phe Leu Lys Gly Ser Ser Ala Gly Val Ile Lys Ser 
                565                 570                 575


Ser Ser Leu Leu Lys Asn Leu Asn 
            580


<210>  5206
<211>  4864
<212>  DNA
<213>  Homo sapiens

<400>  5206
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1080

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1140

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1200

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1260

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1320

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1380

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1440

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1500

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1560

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1620

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1680

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1740

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1800

cgaatacacc agctcaagct cttggactca ccgaggcagt aaaagtacca tatcctgtgt   1860

ttgaatcaaa cccggagttc ttgtatgtgg aaggcttgcc agaggggatt cccttccgaa   1920

gccctacctg gtttggaatt ccacgacttg aaaggatcgt ccgcgggagt aataaaatca   1980

agttcgttgt taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta   2040

aaataaacac taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa   2100

aggttcctga aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag   2160

ctgttcgaac cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag   2220

agttttcctt tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc   2280

tcttcaatga gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg   2340

cgttatttga gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat   2400

tccgaagacc atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca   2460

aaattaagtt catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct   2520

cctctaagag ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag   2580

gtgttgaaga ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct   2640

cgaaagttga aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat   2700

ttggtgaagc tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta   2760

accctggctg tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct   2820

acctggaaat cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg   2880

tcattagacc atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag   2940

aaggccccgt gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag   3000

gtaaaaggac ctcttccctc ctagggtaaa tcagcttctg tgtcagggat gctgtgtggt   3060

gtccatctga accccctgca tacgcgtagc taatgtgatc tccccacttt cacataagat   3120

ggtggccctg ccttcaggga atgtgggagc caggtgggag ccttcccgga tatttaagct   3180

agaagattct acagggagat tctccttgga tcaatatatg tctctcagtc aaagatgtaa   3240

aagcactttt gccttaaaaa gaatgttctg tttctaaata gagtcaacgt tgtcctcctc   3300

attggaattc actatgagtc agaatcatta gactgacttt tttttttcca tagtaatagt   3360

attttgcaga gtctcacaga gctgcagatc ttttgttcat cttgcagagt taacaagtct   3420

gatcctgtta gtccagattt cttaaatttg gccaagttat aataggagca gtagcttgag   3480

acccgaagtc aggaaacttt gacaatggat tttttttttt aatccagaga cttgtactgg   3540

aatttgcctt accctgtcag ctcatggact taaggtttca tcccgcttta tgagtgcttc   3600

tgaatccaag tcattgttac ctgaatttgc aaattaagtt gtgatattcg tgactgttaa   3660

attcctgtaa ttagattaac ctctttgctt gcttgtttgt tttctctcct attttagctt   3720

aaagtatcag tggttgagaa gagcttttcg gacctgttac taccccaagc tgtgtaatat   3780

acttgtataa cagaaatacc ttctatacaa accttttttt ctacttttag atagaaatgt   3840

ctactttttc agcagttctg tgaattaaag agcagagtga ctgtgggtct ggaatggctg   3900

gtgtacttgg gaatgtacta tcaggatttt acagcaatgc tgggaaatga cagggaaaat   3960

gacaggaatg aatctcacca gattttttat gtactcagca gagccttgag ttacggtgtt   4020

tattttccaa tcaagtgaag atatctccta cttctcctac tggaacatct cagcttctgc   4080

agtgaagaaa aattcctgtg atagttcagt tctttagttt ttctatttga aaaaaaaaaa   4140

tcatttaaat gatcctttgt tcacggctct ccttaatgac tgagtgaaca gttcctatct   4200

gtatatttga ctaaaccttt tcctaagcta tctctcatgg ttcctatgtt tttttatcat   4260

aattaaaagc aaaaccatct ggatcaccta acagtcagag gtcagtatct cagcgtgtga   4320

attatagagg aaatacagag agaacctctt ccacttttac ttttcgtcca aataaaatgc   4380

atggtgtacc agaagttgaa gatcgggttg aggattgggg ctagctcgat gacactaagg   4440

ccccaacatc gcgggacctg ctgtggcgcg gattcttagg aacgctgttc tagccggccc   4500

cctctccagg ggtcgccgtg gccggcatta tttcctagtt cttcttgtaa ccctgaggtg   4560

ccagcgcggg gagtgaggag gggtcagggg gctaaggatg caacctctga cgttctgcgc   4620

cttcctagga gagtcttaca tgtgttgaga tttcacaagc aatgcgagtt gtaaaatacc   4680

agctctacaa gaagctaggc tctgtgacgg catagttttc agtagcttta tcacaatatt   4740

cacaatggag aattatatga catggtagca gaaataggcc cttttatgtg ttgcttctat   4800

tttacctcaa attgtagata tagggtaatc aataaaatcc atccatgcct ttcacacact   4860

aagt                                                                4864


<210>  5207
<211>  923
<212>  PRT
<213>  Homo sapiens

<400>  5207

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
        515                 520                 525


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
    530                 535                 540


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
545                 550                 555                 560


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
                565                 570                 575


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
            580                 585                 590


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
        595                 600                 605


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
    610                 615                 620


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
625                 630                 635                 640


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
                645                 650                 655


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
            660                 665                 670


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
        675                 680                 685


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
    690                 695                 700


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
705                 710                 715                 720


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
                725                 730                 735


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
            740                 745                 750


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
        755                 760                 765


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
    770                 775                 780


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
785                 790                 795                 800


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
                805                 810                 815


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
            820                 825                 830


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
        835                 840                 845


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
    850                 855                 860


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro 
865                 870                 875                 880


Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly 
                885                 890                 895


Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala 
            900                 905                 910


Thr Glu Gly Lys Arg Thr Ser Ser Leu Leu Gly 
        915                 920


<210>  5208
<211>  4239
<212>  DNA
<213>  Homo sapiens

<400>  5208
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgcttaga tttgttgaca gcggtttcct ggagtgctgt   1980

cttgagaacg attctgagga ggctcagcaa gaaagagtgt ttcagttgat tgggtgtgtc   2040

tgtcatggag aaggaactca agctcttgga ctcaccgagg cagtaaaagt accatatcct   2100

gtgtttgaat caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc   2160

cgaagcccta cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa   2220

atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct   2280

agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat   2340

tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc   2400

tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg   2460

agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa   2520

aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg   2580

ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg   2640

ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa   2700

gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc   2760

acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca   2820

tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga   2880

ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg   2940

aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca   3000

attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt caaagccccc   3060

agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc   3120

acggtcatta gaccatttcc aggacttgtg attaataacc agctggttga tcagagtgag   3180

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   3240

gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga ccccacgtgg   3300

tagacctctt ccctcctagg cttaaagtat cagtggttga gaagagcttt tcggacctgt   3360

tactacccca agctgtagcc ttgagttacg gtgtttattt tccaatcaag tgaagatatc   3420

tcctacttct cctactggaa catctcagct tctgcagtga agaaaaattc ctgtgatagt   3480

tcagttcttt agtttttcta tttgaaaaaa aaaaatcatt taaatgatcc tttgttcacg   3540

gctctcctta atgactgagt gaacagttcc tatctgtata tttgactaaa ccttttccta   3600

agctatctct catggttcct atgttttttt atcataatta aaagcaaaac catctggatc   3660

acctaacagt cagaggtcag tatctcagcg tgtgaattat agaggaaata cagagagaac   3720

ctcttccact tttacttttc gtccaaataa aatgcatggt gtaccagaag ttgaagatcg   3780

ggttgaggat tggggctagc tcgatgacac taaggcccca acatcgcggg acctgctgtg   3840

gcgcggattc ttaggaacgc tgttctagcc ggccccctct ccaggggtcg ccgtggccgg   3900

cattatttcc tagttcttct tgtaaccctg aggtgccagc gcggggagtg aggaggggtc   3960

agggggctaa ggatgcaacc tctgacgttc tgcgccttcc taggagagtc ttacatgtgt   4020

tgagatttca caagcaatgc gagttgtaaa ataccagctc tacaagaagc taggctctgt   4080

gacggcatag ttttcagtag ctttatcaca atattcacaa tggagaatta tatgacatgg   4140

tagcagaaat aggccctttt atgtgttgct tctattttac ctcaaattgt agatataggg   4200

taatcaataa aatccatcca tgcctttcac acactaagt                          4239


<210>  5209
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  5209

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala 



<210>  5210
<211>  7811
<212>  DNA
<213>  Homo sapiens

<400>  5210
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatt   1080

ctactcaaca tgtcccttca gaaacaagtg aggaccctga agttgaggtg actattgaag   1140

atgatgatta ttctccaccg tctaagagac caaaggccaa tgagctaccg cagccaccag   1200

tcccggaacc cgccaatgct gggaagcgga aagtgaggga gttcaacttc gagaaatgga   1260

atgctcgcat cactgatcta cgtaaacaag ttgaagaatt gtttgaaagg aaatatgctc   1320

aagccataaa agccaaaggt ccggtgacga tcccgtaccc tcttttccag tctcatgttg   1380

aagatcttta tgtagaagga cttcctgaag gaattccttt tagaaggcca tctacttacg   1440

gaattcctcg cctggagagg atattacttg caaaggaaag gattcgtttt gtgattaaga   1500

aacatgagct tctgaattca acacgtgaag atttacagct tgataagcca gcttcaggag   1560

taaaggaaga atggtatgcc agaatcacta aattaagaaa gatggtggat cagcttttct   1620

gcaaaaaatt tgcggaagcc ttggggagca ctgaagccaa ggctgtaccg taccaaaaat   1680

ttgaggcaca cccgaatgat ctgtacgtgg aaggactgcc agaaaacatt cctttccgaa   1740

gtccctcatg gtatggaatc ccaaggctgg aaaaaatcat tcaagtgggc aatcgaatta   1800

aatttgttat taaaagacca gaacttctga ctcacagtac cactgaagtt actcagccaa   1860

gaacgaatac accagtcaaa gaagattgga atgtcagaat taccaagcta cggaagcaag   1920

tggaagagat ttttaatttg aaatttgctc aagctcttgg actcaccgag gcagtaaaag   1980

taccatatcc tgtgtttgaa tcaaacccgg agttcttgta tgtggaaggc ttgccagagg   2040

ggattccctt ccgaagccct acctggtttg gaattccacg acttgaaagg atcgtccgcg   2100

ggagtaataa aatcaagttc gttgttaaaa aacctgaact agttatttcc tacttgcctc   2160

ctgggatggc tagtaaaata aacactaaag ctttgcagtc ccccaaaaga ccacgaagtc   2220

ctgggagtaa ttcaaaggtt cctgaaattg aggtcaccgt ggaaggccct aataacaaca   2280

atcctcaaac ctcagctgtt cgaaccccga cccagactaa cggttctaac gttcccttca   2340

agccacgagg gagagagttt tcctttgagg cctggaatgc caaaatcacg gacctaaaac   2400

agaaagttga aaatctcttc aatgagaaat gtggggaagc tcttggcctt aaacaagctg   2460

tgaaggtgcc gttcgcgtta tttgagtctt tcccggaaga cttttatgtg gaaggcttac   2520

ctgagggtgt gccattccga agaccatcga cttttggcat tccgaggctg gagaagatac   2580

tcagaaacaa agccaaaatt aagttcatca ttaaaaagcc cgaaatgttt gagacggcga   2640

ttaaggagag cacctcctct aagagccctc ccagaaaaat aaattcatca cccaatgtta   2700

atactactgc atcaggtgtt gaagacctta acatcattca ggtgacaatt ccagatgatg   2760

ataatgaaag actctcgaaa gttgaaaaag ctagacagct aagagaacaa gtgaatgacc   2820

tctttagtcg gaaatttggt gaagctattg gtatgggttt tcctgtgaaa gttccctaca   2880

ggaaaatcac aattaaccct ggctgtgtgg tggttgatgg catgcccccg ggggtgtcct   2940

tcaaagcccc cagctacctg gaaatcagct ccatgagaag gatcttagac tctgccgagt   3000

ttatcaaatt cacggtcatt aggtaagtga gagtttcctg cttagtcaca ggagcgaatc   3060

tggagctcat gaggctgact cttctaaaat gcagccacag gtagtcatcg aatccggctt   3120

cctatgctgt gcaatcaaca aatcaaaata acttgtgtca tcattagaat gtcagatgtg   3180

cttctacgaa ctaagctgac tcttttaatt ctttggcaaa gggttggcaa actaggactg   3240

tttgccaaat tcaggctgcc tcctattttt agagtcttcc tgaaacacag ctacacccgt   3300

attatccatg gctgctttcc tgtcacagtg agtaagtagc tgggactgag aaggcatggc   3360

ctccaaagtc taaaatattt actctctagc actttgtaga aaaaccttag ctaggcacag   3420

tggctaacgc ctgtaatccc agcattttgg gaggccaagg caggcagatc acctgaggtc   3480

aggagttcca gaccagcctg gccaacatgg tgaaatccca tctctacaaa aataaaacag   3540

ttagctgggc atgatggcgg gtgcctgtaa tcccagctac tcgggaggct gaggcaggat   3600

agtcgcttga acccaggagg tggaggttgc aatgagccaa gatcatgcca ctgcactcca   3660

gcctggacga cagagtgaga ctccatcaca agaaaaaaag aactttgtca acctctgtct   3720

tagggcgcct tgtcacaggc ttcgggtcag acggattcaa ccttgcatca gccatttgtt   3780

agccaggtca ctctgttctt tgtctgtaaa tgagattgat cgttgttccc actgagagtg   3840

tcagctcctt cccgtagagc aggcatgatg attgtactca cctctgacac cattgtgagt   3900

gccacattcc ttcccacgtc cttgtcactg taagagatgc ccacctgagc accaacccca   3960

ggttatcttc ccctttgtct tccagccccc cagaaacagc tacgactcaa cctacccaat   4020

catttcatca tcagattgcc actgtctcta gttcaggtct cttgggactg gcactcagaa   4080

atctcataat aaatcctctt gaggcttctc atacactcgt cttcttccaa tcttctttcc   4140

ctcaaaatct catattttgg ttccacttca cccaccgtca ttctccatat cactcccagg   4200

agttaggcaa aaagcccctt ccgttcttcc gtatgttaaa cttagaatca ctctgttccc   4260

tgctctgcgt ttctattttt tgtttttcct ccatttacta gtagcttaac actttctaac   4320

agtgttctta ttattgatac gtatctatct cttccataag cttataaggt cacggataat   4380

acttctcatt gtagtacgta aatgacgtgg gctagatatg agttgaataa acagttatac   4440

ctgtaaattc ttacagagtg aaaataaatt gttatacttt acaatttgtt tctctcttta   4500

gaccatttcc aggacttgtg attaataacc gtgagtattt tgtgaagtgt tttgtttttg   4560

ttttttcctg gggtctgacg tgtgtgcgtg tgagtgtgta tacatgctta acgtatatca   4620

cgttacttca cctatgtcag taaccaggcc aaatacttgt tttagccctc agtaaaaaca   4680

ccaggcactt cctagttgta aaattattca agcttcttaa cttcctatcc tcgatgcact   4740

taatcataaa atggtaataa tagcaccgat tttgggggag tcgttccagt agatggaaag   4800

catctggaac aggtgtcagc aagctcctgc cgacgtgtat gcataaagtt ttattgaaac   4860

caccatcgtg tccatttgtt tatggcagaa ctgagagatg gcagcagcaa gtgtgtgcct   4920

gcaaaaccta aaatatttac taattggctc tgcaagaaaa gagtttgcat ccccctaacc   4980

tagaacagtg tctagcctct agtatgtgtt tagcctacag tatgtgctca gcgaatacaa   5040

tctatattta ttactgcttt tatgactgtt ataattactg tgcttggatt tcgttacaaa   5100

gtaagtcaca atgtgcctgc ttctgttagt atttcagcac agtgcctggc acacatgggg   5160

ctctcaaata ttgctgagcg agtgaacaaa tgtcctttca attccttaac gttgatgtca   5220

ttttcaatag tattttgagc caaacttaat tttgcgagtg tgttttgttt tcttaacttt   5280

attattaaaa atgtataaaa gtgaggccag gcgtggtggc tcacgcctgt aatcccagca   5340

gtttgggagg ctgaggcagg cggatcagtt gaggttggga gttggagacc agcccgtcca   5400

acatggtgaa agcctgtctc tactaaaaat acaaaaatca gctgggtgtg gtggcgcgtg   5460

cctgtaatcc cagctactca ggaggctgag gcaggagagt tgcttgaatc ctagaggtgg   5520

aggttgcagt gagctgagat cgtgccattg cactccagcc tgggcaacaa gagcaaaact   5580

ctgtcccaat aaataaataa ataaaatgtt ctcttttgtt cctgttcttg tgcggtagtg   5640

tggtatagag ttttatggta attactgtga attagtgatt ctgagggaca tatcagaact   5700

ctgaggtttg tttccttctc atcttgaggg aaacagcaaa tgtatgttaa aatgcttttc   5760

caagggaaca acacatcctt acattattta aaccaatctg cttcattttc agagctggtt   5820

gatcagagtg agtcagaagg ccccgtgata caagaatcag ctgaaccaag ccagttggaa   5880

gttccagcca cagaagaaat aaaagagact gatggaagct ctcagatcaa gcaagaacca   5940

gaccccacgt ggtagacctc ttccctccta gggtaaatca gcttctgtgt cagggatgct   6000

gtgtggtgtc catctgaacc ccctgcatac gcgtagctaa tgtgatctcc ccactttcac   6060

ataagatggt ggccctgcct tcagggaatg tgggagccag gtgggagcct tcccggatat   6120

ttaagctaga agattctaca gggagattct ccttggatca atatatgtct ctcagtcaaa   6180

gatgtaaaag cacttttgcc ttaaaaagaa tgttctgttt ctaaatagag tcaacgttgt   6240

cctcctcatt ggaattcact atgagtcaga atcattagac tgactttttt ttttccatag   6300

taatagtatt ttgcagagtc tcacagagct gcagatcttt tgttcatctt gcagagttaa   6360

caagtctgat cctgttagtc cagatttctt aaatttggcc aagttataat aggagcagta   6420

gcttgagacc cgaagtcagg aaactttgac aatggatttt tttttttaat ccagagactt   6480

gtactggaat ttgccttacc ctgtcagctc atggacttaa ggtttcatcc cgctttatga   6540

gtgcttctga atccaagtca ttgttacctg aatttgcaaa ttaagttgtg atattcgtga   6600

ctgttaaatt cctgtaatta gattaacctc tttgcttgct tgtttgtttt ctctcctatt   6660

ttagcttaaa gtatcagtgg ttgagaagag cttttcggac ctgttactac cccaagctgt   6720

gtaatatact tgtataacag aaataccttc tatacaaacc tttttttcta cttttagata   6780

gaaatgtcta ctttttcagc agttctgtga attaaagagc agagtgactg tgggtctgga   6840

atggctggtg tacttgggaa tgtactatca ggattttaca gcaatgctgg gaaatgacag   6900

ggaaaatgac aggaatgaat ctcaccagat tttttatgta ctcagcagag ccttgagtta   6960

cggtgtttat tttccaatca agtgaagata tctcctactt ctcctactgg aacatctcag   7020

cttctgcagt gaagaaaaat tcctgtgata gttcagttct ttagtttttc tatttgaaaa   7080

aaaaaaatca tttaaatgat cctttgttca cggctctcct taatgactga gtgaacagtt   7140

cctatctgta tatttgacta aaccttttcc taagctatct ctcatggttc ctatgttttt   7200

ttatcataat taaaagcaaa accatctgga tcacctaaca gtcagaggtc agtatctcag   7260

cgtgtgaatt atagaggaaa tacagagaga acctcttcca cttttacttt tcgtccaaat   7320

aaaatgcatg gtgtaccaga agttgaagat cgggttgagg attggggcta gctcgatgac   7380

actaaggccc caacatcgcg ggacctgctg tggcgcggat tcttaggaac gctgttctag   7440

ccggccccct ctccaggggt cgccgtggcc ggcattattt cctagttctt cttgtaaccc   7500

tgaggtgcca gcgcggggag tgaggagggg tcagggggct aaggatgcaa cctctgacgt   7560

tctgcgcctt cctaggagag tcttacatgt gttgagattt cacaagcaat gcgagttgta   7620

aaataccagc tctacaagaa gctaggctct gtgacggcat agttttcagt agctttatca   7680

caatattcac aatggagaat tatatgacat ggtagcagaa ataggccctt ttatgtgttg   7740

cttctatttt acctcaaatt gtagatatag ggtaatcaat aaaatccatc catgcctttc   7800

acacactaag t                                                        7811


<210>  5211
<211>  922
<212>  PRT
<213>  Homo sapiens

<400>  5211

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Ser Thr Gln His Val Pro Ser Glu Thr Ser Glu Asp Pro Glu 
        275                 280                 285


Val Glu Val Thr Ile Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg 
    290                 295                 300


Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn 
305                 310                 315                 320


Ala Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala 
                325                 330                 335


Arg Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys 
            340                 345                 350


Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro 
        355                 360                 365


Leu Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu 
    370                 375                 380


Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu 
385                 390                 395                 400


Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His 
                405                 410                 415


Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala 
            420                 425                 430


Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys 
        435                 440                 445


Met Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser 
    450                 455                 460


Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn 
465                 470                 475                 480


Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro 
                485                 490                 495


Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn 
            500                 505                 510


Arg Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr 
        515                 520                 525


Thr Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp 
    530                 535                 540


Asn Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn 
545                 550                 555                 560


Leu Lys Phe Ala Gln Ala Leu Gly Leu Thr Glu Ala Val Lys Val Pro 
                565                 570                 575


Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val Glu Gly Leu 
            580                 585                 590


Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly Ile Pro Arg 
        595                 600                 605


Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe Val Val Lys 
    610                 615                 620


Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met Ala Ser Lys 
625                 630                 635                 640


Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg Ser Pro Gly 
                645                 650                 655


Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu Gly Pro Asn 
            660                 665                 670


Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr Gln Thr Asn 
        675                 680                 685


Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe Ser Phe Glu 
    690                 695                 700


Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val Glu Asn Leu 
705                 710                 715                 720


Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln Ala Val Lys 
                725                 730                 735


Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe Tyr Val Glu 
            740                 745                 750


Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr Phe Gly Ile 
        755                 760                 765


Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile Lys Phe Ile 
    770                 775                 780


Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu Ser Thr Ser 
785                 790                 795                 800


Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn Val Asn Thr 
                805                 810                 815


Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val Thr Ile Pro 
            820                 825                 830


Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala Arg Gln Leu 
        835                 840                 845


Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly Glu Ala Ile 
    850                 855                 860


Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile Thr Ile Asn 
865                 870                 875                 880


Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val Ser Phe Lys 
                885                 890                 895


Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile Leu Asp Ser 
            900                 905                 910


Ala Glu Phe Ile Lys Phe Thr Val Ile Arg 
        915                 920


<210>  5212
<211>  4392
<212>  DNA
<213>  Homo sapiens

<400>  5212
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggaagccac cattcttcag    960

agggcaatga aggcacagaa atggaagtac cagcagaaga ttctactcaa catgtccctt   1020

cagaaacaag tgaggaccct gaagttgagg tgactattga agatgatgat tattctccac   1080

cgtctaagag accaaaggcc aatgagctac cgcagccacc agtcccggaa cccgccaatg   1140

ctgggaagcg gaaagtgagg gagttcaact tcgagaaatg gaatgctcgc atcactgatc   1200

tacgtaaaca agttgaagaa ttgtttgaaa ggaaatatgc tcaagccata aaagccaaag   1260

gtccggtgac gatcccgtac cctcttttcc agtctcatgt tgaagatctt tatgtagaag   1320

gacttcctga aggaattcct tttagaaggc catctactta cggaattcct cgcctggaga   1380

ggatattact tgcaaaggaa aggattcgtt ttgtgattaa gaaacatgag cttctgaatt   1440

caacacgtga agatttacag cttgataagc cagcttcagg agtaaaggaa gaatggtatg   1500

ccagaatcac taaattaaga aagatggtgg atcagctttt ctgcaaaaaa tttgcggaag   1560

ccttggggag cactgaagcc aaggctgtac cgtaccaaaa atttgaggca cacccgaatg   1620

atctgtacgt ggaaggactg ccagaaaaca ttcctttccg aagtccctca tggtatggaa   1680

tcccaaggct ggaaaaaatc attcaagtgg gcaatcgaat taaatttgtt attaaaagac   1740

cagaacttct gactcacagt accactgaag ttactcagcc aagaacgaat acaccagtca   1800

aagaagattg gaatgtcaga attaccaagc tacggaagca agtggaagag atttttaatt   1860

tgaaatttgc ttagatttgt tgacagcggt ttcctggagt gctgtcttga gaacgattct   1920

gaggaggctc agcaagaaag agtgtttcag ttgattgggt gtgtctgtca tggagaagga   1980

actcaagctc ttggactcac cgaggcagta aaagtaccat atcctgtgtt tgaatcaaac   2040

ccggagttct tgtatgtgga aggcttgcca gaggggattc ccttccgaag ccctacctgg   2100

tttggaattc cacgacttga aaggatcgtc cgcgggagta ataaaatcaa gttcgttgtt   2160

aaaaaacctg aactagttat ttcctacttg cctcctggga tggctagtaa aataaacact   2220

aaagctttgc agtcccccaa aagaccacga agtcctggga gtaattcaaa ggttcctgaa   2280

attgaggtca ccgtggaagg ccctaataac aacaatcctc aaacctcagc tgttcgaacc   2340

ccgacccaga ctaacggttc taacgttccc ttcaagccac gagggagaga gttttccttt   2400

gaggcctgga atgccaaaat cacggaccta aaacagaaag ttgaaaatct cttcaatgag   2460

aaatgtgggg aagctcttgg ccttaaacaa gctgtgaagg tgccgttcgc gttatttgag   2520

tctttcccgg aagactttta tgtggaaggc ttacctgagg gtgtgccatt ccgaagacca   2580

tcgacttttg gcattccgag gctggagaag atactcagaa acaaagccaa aattaagttc   2640

atcattaaaa agcccgaaat gtttgagacg gcgattaagg agagcacctc ctctaagagc   2700

cctcccagaa aaataaattc atcacccaat gttaatacta ctgcatcagg tgttgaagac   2760

cttaacatca ttcaggtgac aattccagat gatgataatg aaagactctc gaaagttgaa   2820

aaagctagac agctaagaga acaagtgaat gacctcttta gtcggaaatt tggtgaagct   2880

attggtatgg gttttcctgt gaaagttccc tacaggaaaa tcacaattaa ccctggctgt   2940

gtggtggttg atggcatgcc cccgggggtg tccttcaaag cccccagcta cctggaaatc   3000

agctccatga gaaggatctt agactctgcc gagtttatca aattcacggt cattagacca   3060

tttccaggac ttgtgattaa taaccagctg gttgatcaga gtgagtcaga aggccccgtg   3120

atacaagaat cagctgaacc aagccagttg gaagttccag ccacagaaga aataaaagag   3180

actgatggaa gctctcagat caagcaagaa ccagacccca cgtggtagac ctcttccctc   3240

ctaggcttaa agtatcagtg gttgagaaga gcttttcgga cctgttacta ccccaagctg   3300

tgtaatatac ttgtataaca gaaatacctt ctatacaaac ctttttttct acttttagat   3360

agaaatgtct actttttcag cagttctgtg aattaaagag cagagtgact gtgggtctgg   3420

aatggctggt gtacttggga atgtactatc aggattttac agcaatgctg ggaaatgaca   3480

gggaaaatga caggaatgaa tctcaccaga ttttttatgt actcagcaga gccttgagtt   3540

acggtgttta ttttccaatc aagtgaagat atctcctact tctcctactg gaacatctca   3600

gcttctgcag tgaagaaaaa ttcctgtgat agttcagttc tttagttttt ctatttgaaa   3660

aaaaaaaatc atttaaatga tcctttgttc acggctctcc ttaatgactg agtgaacagt   3720

tcctatctgt atatttgact aaaccttttc ctaagctatc tctcatggtt cctatgtttt   3780

tttatcataa ttaaaagcaa aaccatctgg atcacctaac agtcagaggt cagtatctca   3840

gcgtgtgaat tatagaggaa atacagagag aacctcttcc acttttactt ttcgtccaaa   3900

taaaatgcat ggtgtaccag aagttgaaga tcgggttgag gattggggct agctcgatga   3960

cactaaggcc ccaacatcgc gggacctgct gtggcgcgga ttcttaggaa cgctgttcta   4020

gccggccccc tctccagggg tcgccgtggc cggcattatt tcctagttct tcttgtaacc   4080

ctgaggtgcc agcgcgggga gtgaggaggg gtcagggggc taaggatgca acctctgacg   4140

ttctgcgcct tcctaggaga gtcttacatg tgttgagatt tcacaagcaa tgcgagttgt   4200

aaaataccag ctctacaaga agctaggctc tgtgacggca tagttttcag tagctttatc   4260

acaatattca caatggagaa ttatatgaca tggtagcaga aataggccct tttatgtgtt   4320

gcttctattt tacctcaaat tgtagatata gggtaatcaa taaaatccat ccatgccttt   4380

cacacactaa gt                                                       4392


<210>  5213
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  5213

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr 
225                 230                 235                 240


Glu Met Glu Val Pro Ala Glu Asp Ser Thr Gln His Val Pro Ser Glu 
                245                 250                 255


Thr Ser Glu Asp Pro Glu Val Glu Val Thr Ile Glu Asp Asp Asp Tyr 
            260                 265                 270


Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu Leu Pro Gln Pro Pro 
        275                 280                 285


Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys Val Arg Glu Phe Asn 
    290                 295                 300


Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu Arg Lys Gln Val Glu 
305                 310                 315                 320


Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile Lys Ala Lys Gly Pro 
                325                 330                 335


Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His Val Glu Asp Leu Tyr 
            340                 345                 350


Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Arg Pro Ser Thr Tyr 
        355                 360                 365


Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala Lys Glu Arg Ile Arg 
    370                 375                 380


Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser Thr Arg Glu Asp Leu 
385                 390                 395                 400


Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu Glu Trp Tyr Ala Arg 
                405                 410                 415


Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu Phe Cys Lys Lys Phe 
            420                 425                 430


Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala Val Pro Tyr Gln Lys 
        435                 440                 445


Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu Gly Leu Pro Glu Asn 
    450                 455                 460


Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile Pro Arg Leu Glu Lys 
465                 470                 475                 480


Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val Ile Lys Arg Pro Glu 
                485                 490                 495


Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln Pro Arg Thr Asn Thr 
            500                 505                 510


Pro Val Lys Glu Asp Trp Asn Val Arg Ile Thr Lys Leu Arg Lys Gln 
        515                 520                 525


Val Glu Glu Ile Phe Asn Leu Lys Phe Ala 
    530                 535


<210>  5214
<211>  4183
<212>  DNA
<213>  Homo sapiens

<400>  5214
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

caggcccttc tgaaactgat gatgttgatg aaaaacagcc cctatcgaag cctttgcaag   1080

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1140

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1200

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1260

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1320

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1380

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1440

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1500

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1560

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1620

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1680

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1740

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1800

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1860

cgaatacacc agtcaaagaa gattggaatg tcagaattac caagctacgg aagcaagtgg   1920

aagagatttt taatttgaaa tttgcttaga tttgttgaca gcggtttcct ggagtgctgt   1980

cttgagaacg attctgagga ggctcagcaa gaaagagtgt ttcagttgat tgggtgtgtc   2040

tgtcatggag aaggaactca agctcttgga ctcaccgagg cagtaaaagt accatatcct   2100

gtgtttgaat caaacccgga gttcttgtat gtggaaggct tgccagaggg gattcccttc   2160

cgaagcccta cctggtttgg aattccacga cttgaaagga tcgtccgcgg gagtaataaa   2220

atcaagttcg ttgttaaaaa acctgaacta gttatttcct acttgcctcc tgggatggct   2280

agtaaaataa acactaaagc tttgcagtcc cccaaaagac cacgaagtcc tgggagtaat   2340

tcaaaggttc ctgaaattga ggtcaccgtg gaaggcccta ataacaacaa tcctcaaacc   2400

tcagctgttc gaaccccgac ccagactaac ggttctaacg ttcccttcaa gccacgaggg   2460

agagagtttt cctttgaggc ctggaatgcc aaaatcacgg acctaaaaca gaaagttgaa   2520

aatctcttca atgagaaatg tggggaagct cttggcctta aacaagctgt gaaggtgccg   2580

ttcgcgttat ttgagtcttt cccggaagac ttttatgtgg aaggcttacc tgagggtgtg   2640

ccattccgaa gaccatcgac ttttggcatt ccgaggctgg agaagatact cagaaacaaa   2700

gccaaaatta agttcatcat taaaaagccc gaaatgtttg agacggcgat taaggagagc   2760

acctcctcta agagccctcc cagaaaaata aattcatcac ccaatgttaa tactactgca   2820

tcaggtgttg aagaccttaa catcattcag gtgacaattc cagatgatga taatgaaaga   2880

ctctcgaaag ttgaaaaagc tagacagcta agagaacaag tgaatgacct ctttagtcgg   2940

aaatttggtg aagctattgg tatgggtttt cctgtgaaag ttccctacag gaaaatcaca   3000

attaaccctg gctgtgtggt ggttgatggc atgcccccgg gggtgtcctt caaagccccc   3060

agctacctgg aaatcagctc catgagaagg atcttagact ctgccgagtt tatcaaattc   3120

acggtcatta gaccatttcc aggacttgtg attaataacc agctggttga tcagagtgag   3180

tcagaaggcc ccgtgataca agaatcagct gaaccaagcc agttggaagt tccagccaca   3240

gaagaaataa aagagactga tggaagctct cagatcaagc aagaaccaga ccccacgtgg   3300

tagacctctt ccctcctagg agccttgagt tacggtgttt attttccaat caagtgaaga   3360

tatctcctac ttctcctact ggaacatctc agcttctgca gtgaagaaaa attcctgtga   3420

tagttcagtt ctttagtttt tctatttgaa aaaaaaaaat catttaaatg atcctttgtt   3480

cacggctctc cttaatgact gagtgaacag ttcctatctg tatatttgac taaacctttt   3540

cctaagctat ctctcatggt tcctatgttt ttttatcata attaaaagca aaaccatctg   3600

gatcacctaa cagtcagagg tcagtatctc agcgtgtgaa ttatagagga aatacagaga   3660

gaacctcttc cacttttact tttcgtccaa ataaaatgca tggtgtacca gaagttgaag   3720

atcgggttga ggattggggc tagctcgatg acactaaggc cccaacatcg cgggacctgc   3780

tgtggcgcgg attcttagga acgctgttct agccggcccc ctctccaggg gtcgccgtgg   3840

ccggcattat ttcctagttc ttcttgtaac cctgaggtgc cagcgcgggg agtgaggagg   3900

ggtcaggggg ctaaggatgc aacctctgac gttctgcgcc ttcctaggag agtcttacat   3960

gtgttgagat ttcacaagca atgcgagttg taaaatacca gctctacaag aagctaggct   4020

ctgtgacggc atagttttca gtagctttat cacaatattc acaatggaga attatatgac   4080

atggtagcag aaataggccc ttttatgtgt tgcttctatt ttacctcaaa ttgtagatat   4140

agggtaatca ataaaatcca tccatgcctt tcacacacta agt                     4183


<210>  5215
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  5215

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Ala Gly 
                245                 250                 255


Pro Ser Glu Thr Asp Asp Val Asp Glu Lys Gln Pro Leu Ser Lys Pro 
            260                 265                 270


Leu Gln Gly Ser His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met 
        275                 280                 285


Glu Val Pro Ala Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro 
    290                 295                 300


Lys Ala Asn Glu Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala 
305                 310                 315                 320


Gly Lys Arg Lys Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg 
                325                 330                 335


Ile Thr Asp Leu Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr 
            340                 345                 350


Ala Gln Ala Ile Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu 
        355                 360                 365


Phe Gln Ser His Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly 
    370                 375                 380


Ile Pro Phe Arg Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg 
385                 390                 395                 400


Ile Leu Leu Ala Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu 
                405                 410                 415


Leu Leu Asn Ser Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser 
            420                 425                 430


Gly Val Lys Glu Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met 
        435                 440                 445


Val Asp Gln Leu Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr 
    450                 455                 460


Glu Ala Lys Ala Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp 
465                 470                 475                 480


Leu Tyr Val Glu Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser 
                485                 490                 495


Trp Tyr Gly Ile Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg 
            500                 505                 510


Ile Lys Phe Val Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr 
        515                 520                 525


Glu Val Thr Gln Pro Arg Thr Asn Thr Pro Val Lys Glu Asp Trp Asn 
    530                 535                 540


Val Arg Ile Thr Lys Leu Arg Lys Gln Val Glu Glu Ile Phe Asn Leu 
545                 550                 555                 560


Lys Phe Ala 



<210>  5216
<211>  3939
<212>  DNA
<213>  Homo sapiens

<400>  5216
gggtcttgtt ctgtctccca agctggagtg cagtggtgtg gtcataggtc actgcagcgt     60

cgaactccta ggctcaagtg atcctcttgc ctcaggctcc tgagtagctg ggacaacagg    120

cgtgtaccac acctggatac tttttaaatt tttggtagag aagggatctc actctattgc    180

caagctggtg tcgaactctt ggtcttaagc agccctccca cgtcagcatc ccaaagtgtt    240

gggatttcag agggatcatg gcccaagttg caatgtccac cctccccgtt gaagatgagg    300

agtcctcgga gagcaggatg gtggtgacat tcctcatgtc agctctcgag tccatgtgta    360

aagaactggc caagtccaaa gccgaagtgg cctgcattgc agtgtatgaa acagacgtgt    420

ttgtcgtcgg aactgaaaga ggacgtgctt ttgtcaatac cagaaaggat tttcaaaaag    480

attttgtaaa atattgtgtt gaagaagaag aaaaagctgc agagatgcat aaaatgaaat    540

ctacaaccca ggcaaatcgg atgagtgtag atgctgtaga aattgaaaca ctcagaaaaa    600

cagttgagga ctatttctgc ttttgctatg ggaaagcttt aggcaaatcc acagtggtac    660

ctgtaccata tgagaagatg ctgcgagacc agtcggctgt ggtagtgcag gggcttccgg    720

aaggtgttgc ctttaaacac cccgagaact atgatcttgc aaccctgaaa tggattttgg    780

agaacaaagc agggatttca ttcatcatta agagaccttt tttagagcca aagaagcatg    840

taggtggtcg tgtgatggta acagatgctg acaggtcaat actatctcca ggtggaagtt    900

gtggccccat caaagtgaaa actgaaccca cagaagattc tggcatttcc ctggaaatgg    960

cagctgtgac agtaaaggaa gaatcagaag atcctgatta ttatcaatat aacattcaag   1020

gaagccacca ttcttcagag ggcaatgaag gcacagaaat ggaagtacca gcagaagatg   1080

atgattattc tccaccgtct aagagaccaa aggccaatga gctaccgcag ccaccagtcc   1140

cggaacccgc caatgctggg aagcggaaag tgagggagtt caacttcgag aaatggaatg   1200

ctcgcatcac tgatctacgt aaacaagttg aagaattgtt tgaaaggaaa tatgctcaag   1260

ccataaaagc caaaggtccg gtgacgatcc cgtaccctct tttccagtct catgttgaag   1320

atctttatgt agaaggactt cctgaaggaa ttccttttag aaggccatct acttacggaa   1380

ttcctcgcct ggagaggata ttacttgcaa aggaaaggat tcgttttgtg attaagaaac   1440

atgagcttct gaattcaaca cgtgaagatt tacagcttga taagccagct tcaggagtaa   1500

aggaagaatg gtatgccaga atcactaaat taagaaagat ggtggatcag cttttctgca   1560

aaaaatttgc ggaagccttg gggagcactg aagccaaggc tgtaccgtac caaaaatttg   1620

aggcacaccc gaatgatctg tacgtggaag gactgccaga aaacattcct ttccgaagtc   1680

cctcatggta tggaatccca aggctggaaa aaatcattca agtgggcaat cgaattaaat   1740

ttgttattaa aagaccagaa cttctgactc acagtaccac tgaagttact cagccaagaa   1800

cgaatacacc agctcaagct cttggactca ccgaggcagt aaaagtacca tatcctgtgt   1860

ttgaatcaaa cccggagttc ttgtatgtgg aaggcttgcc agaggggatt cccttccgaa   1920

gccctacctg gtttggaatt ccacgacttg aaaggatcgt ccgcgggagt aataaaatca   1980

agttcgttgt taaaaaacct gaactagtta tttcctactt gcctcctggg atggctagta   2040

aaataaacac taaagctttg cagtccccca aaagaccacg aagtcctggg agtaattcaa   2100

aggttcctga aattgaggtc accgtggaag gccctaataa caacaatcct caaacctcag   2160

ctgttcgaac cccgacccag actaacggtt ctaacgttcc cttcaagcca cgagggagag   2220

agttttcctt tgaggcctgg aatgccaaaa tcacggacct aaaacagaaa gttgaaaatc   2280

tcttcaatga gaaatgtggg gaagctcttg gccttaaaca agctgtgaag gtgccgttcg   2340

cgttatttga gtctttcccg gaagactttt atgtggaagg cttacctgag ggtgtgccat   2400

tccgaagacc atcgactttt ggcattccga ggctggagaa gatactcaga aacaaagcca   2460

aaattaagtt catcattaaa aagcccgaaa tgtttgagac ggcgattaag gagagcacct   2520

cctctaagag ccctcccaga aaaataaatt catcacccaa tgttaatact actgcatcag   2580

gtgttgaaga ccttaacatc attcaggtga caattccaga tgatgataat gaaagactct   2640

cgaaagttga aaaagctaga cagctaagag aacaagtgaa tgacctcttt agtcggaaat   2700

ttggtgaagc tattggtatg ggttttcctg tgaaagttcc ctacaggaaa atcacaatta   2760

accctggctg tgtggtggtt gatggcatgc ccccgggggt gtccttcaaa gcccccagct   2820

acctggaaat cagctccatg agaaggatct tagactctgc cgagtttatc aaattcacgg   2880

tcattagacc atttccagga cttgtgatta ataaccagct ggttgatcag agtgagtcag   2940

aaggccccgt gatacaagaa tcagctgaac caagccagtt ggaagttcca gccacagaag   3000

aaataaaaga gactgatgga agctctcaga tcaagcaaga accagacccc acgtggtaga   3060

cctcttccct cctaggagcc ttgagttacg gtgtttattt tccaatcaag tgaagatatc   3120

tcctacttct cctactggaa catctcagct tctgcagtga agaaaaattc ctgtgatagt   3180

tcagttcttt agtttttcta tttgaaaaaa aaaaatcatt taaatgatcc tttgttcacg   3240

gctctcctta atgactgagt gaacagttcc tatctgtata tttgactaaa ccttttccta   3300

agctatctct catggttcct atgttttttt atcataatta aaagcaaaac catctggatc   3360

acctaacagt cagaggtcag tatctcagcg tgtgaattat agaggaaata cagagagaac   3420

ctcttccact tttacttttc gtccaaataa aatgcatggt gtaccagaag ttgaagatcg   3480

ggttgaggat tggggctagc tcgatgacac taaggcccca acatcgcggg acctgctgtg   3540

gcgcggattc ttaggaacgc tgttctagcc ggccccctct ccaggggtcg ccgtggccgg   3600

cattatttcc tagttcttct tgtaaccctg aggtgccagc gcggggagtg aggaggggtc   3660

agggggctaa ggatgcaacc tctgacgttc tgcgccttcc taggagagtc ttacatgtgt   3720

tgagatttca caagcaatgc gagttgtaaa ataccagctc tacaagaagc taggctctgt   3780

gacggcatag ttttcagtag ctttatcaca atattcacaa tggagaatta tatgacatgg   3840

tagcagaaat aggccctttt atgtgttgct tctattttac ctcaaattgt agatataggg   3900

taatcaataa aatccatcca tgcctttcac acactaagt                          3939


<210>  5217
<211>  933
<212>  PRT
<213>  Homo sapiens

<400>  5217

Met Ala Gln Val Ala Met Ser Thr Leu Pro Val Glu Asp Glu Glu Ser 
1               5                   10                  15


Ser Glu Ser Arg Met Val Val Thr Phe Leu Met Ser Ala Leu Glu Ser 
            20                  25                  30


Met Cys Lys Glu Leu Ala Lys Ser Lys Ala Glu Val Ala Cys Ile Ala 
        35                  40                  45


Val Tyr Glu Thr Asp Val Phe Val Val Gly Thr Glu Arg Gly Arg Ala 
    50                  55                  60


Phe Val Asn Thr Arg Lys Asp Phe Gln Lys Asp Phe Val Lys Tyr Cys 
65                  70                  75                  80


Val Glu Glu Glu Glu Lys Ala Ala Glu Met His Lys Met Lys Ser Thr 
                85                  90                  95


Thr Gln Ala Asn Arg Met Ser Val Asp Ala Val Glu Ile Glu Thr Leu 
            100                 105                 110


Arg Lys Thr Val Glu Asp Tyr Phe Cys Phe Cys Tyr Gly Lys Ala Leu 
        115                 120                 125


Gly Lys Ser Thr Val Val Pro Val Pro Tyr Glu Lys Met Leu Arg Asp 
    130                 135                 140


Gln Ser Ala Val Val Val Gln Gly Leu Pro Glu Gly Val Ala Phe Lys 
145                 150                 155                 160


His Pro Glu Asn Tyr Asp Leu Ala Thr Leu Lys Trp Ile Leu Glu Asn 
                165                 170                 175


Lys Ala Gly Ile Ser Phe Ile Ile Lys Arg Pro Phe Leu Glu Pro Lys 
            180                 185                 190


Lys His Val Gly Gly Arg Val Met Val Thr Asp Ala Asp Arg Ser Ile 
        195                 200                 205


Leu Ser Pro Gly Gly Ser Cys Gly Pro Ile Lys Val Lys Thr Glu Pro 
    210                 215                 220


Thr Glu Asp Ser Gly Ile Ser Leu Glu Met Ala Ala Val Thr Val Lys 
225                 230                 235                 240


Glu Glu Ser Glu Asp Pro Asp Tyr Tyr Gln Tyr Asn Ile Gln Gly Ser 
                245                 250                 255


His His Ser Ser Glu Gly Asn Glu Gly Thr Glu Met Glu Val Pro Ala 
            260                 265                 270


Glu Asp Asp Asp Tyr Ser Pro Pro Ser Lys Arg Pro Lys Ala Asn Glu 
        275                 280                 285


Leu Pro Gln Pro Pro Val Pro Glu Pro Ala Asn Ala Gly Lys Arg Lys 
    290                 295                 300


Val Arg Glu Phe Asn Phe Glu Lys Trp Asn Ala Arg Ile Thr Asp Leu 
305                 310                 315                 320


Arg Lys Gln Val Glu Glu Leu Phe Glu Arg Lys Tyr Ala Gln Ala Ile 
                325                 330                 335


Lys Ala Lys Gly Pro Val Thr Ile Pro Tyr Pro Leu Phe Gln Ser His 
            340                 345                 350


Val Glu Asp Leu Tyr Val Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg 
        355                 360                 365


Arg Pro Ser Thr Tyr Gly Ile Pro Arg Leu Glu Arg Ile Leu Leu Ala 
    370                 375                 380


Lys Glu Arg Ile Arg Phe Val Ile Lys Lys His Glu Leu Leu Asn Ser 
385                 390                 395                 400


Thr Arg Glu Asp Leu Gln Leu Asp Lys Pro Ala Ser Gly Val Lys Glu 
                405                 410                 415


Glu Trp Tyr Ala Arg Ile Thr Lys Leu Arg Lys Met Val Asp Gln Leu 
            420                 425                 430


Phe Cys Lys Lys Phe Ala Glu Ala Leu Gly Ser Thr Glu Ala Lys Ala 
        435                 440                 445


Val Pro Tyr Gln Lys Phe Glu Ala His Pro Asn Asp Leu Tyr Val Glu 
    450                 455                 460


Gly Leu Pro Glu Asn Ile Pro Phe Arg Ser Pro Ser Trp Tyr Gly Ile 
465                 470                 475                 480


Pro Arg Leu Glu Lys Ile Ile Gln Val Gly Asn Arg Ile Lys Phe Val 
                485                 490                 495


Ile Lys Arg Pro Glu Leu Leu Thr His Ser Thr Thr Glu Val Thr Gln 
            500                 505                 510


Pro Arg Thr Asn Thr Pro Ala Gln Ala Leu Gly Leu Thr Glu Ala Val 
        515                 520                 525


Lys Val Pro Tyr Pro Val Phe Glu Ser Asn Pro Glu Phe Leu Tyr Val 
    530                 535                 540


Glu Gly Leu Pro Glu Gly Ile Pro Phe Arg Ser Pro Thr Trp Phe Gly 
545                 550                 555                 560


Ile Pro Arg Leu Glu Arg Ile Val Arg Gly Ser Asn Lys Ile Lys Phe 
                565                 570                 575


Val Val Lys Lys Pro Glu Leu Val Ile Ser Tyr Leu Pro Pro Gly Met 
            580                 585                 590


Ala Ser Lys Ile Asn Thr Lys Ala Leu Gln Ser Pro Lys Arg Pro Arg 
        595                 600                 605


Ser Pro Gly Ser Asn Ser Lys Val Pro Glu Ile Glu Val Thr Val Glu 
    610                 615                 620


Gly Pro Asn Asn Asn Asn Pro Gln Thr Ser Ala Val Arg Thr Pro Thr 
625                 630                 635                 640


Gln Thr Asn Gly Ser Asn Val Pro Phe Lys Pro Arg Gly Arg Glu Phe 
                645                 650                 655


Ser Phe Glu Ala Trp Asn Ala Lys Ile Thr Asp Leu Lys Gln Lys Val 
            660                 665                 670


Glu Asn Leu Phe Asn Glu Lys Cys Gly Glu Ala Leu Gly Leu Lys Gln 
        675                 680                 685


Ala Val Lys Val Pro Phe Ala Leu Phe Glu Ser Phe Pro Glu Asp Phe 
    690                 695                 700


Tyr Val Glu Gly Leu Pro Glu Gly Val Pro Phe Arg Arg Pro Ser Thr 
705                 710                 715                 720


Phe Gly Ile Pro Arg Leu Glu Lys Ile Leu Arg Asn Lys Ala Lys Ile 
                725                 730                 735


Lys Phe Ile Ile Lys Lys Pro Glu Met Phe Glu Thr Ala Ile Lys Glu 
            740                 745                 750


Ser Thr Ser Ser Lys Ser Pro Pro Arg Lys Ile Asn Ser Ser Pro Asn 
        755                 760                 765


Val Asn Thr Thr Ala Ser Gly Val Glu Asp Leu Asn Ile Ile Gln Val 
    770                 775                 780


Thr Ile Pro Asp Asp Asp Asn Glu Arg Leu Ser Lys Val Glu Lys Ala 
785                 790                 795                 800


Arg Gln Leu Arg Glu Gln Val Asn Asp Leu Phe Ser Arg Lys Phe Gly 
                805                 810                 815


Glu Ala Ile Gly Met Gly Phe Pro Val Lys Val Pro Tyr Arg Lys Ile 
            820                 825                 830


Thr Ile Asn Pro Gly Cys Val Val Val Asp Gly Met Pro Pro Gly Val 
        835                 840                 845


Ser Phe Lys Ala Pro Ser Tyr Leu Glu Ile Ser Ser Met Arg Arg Ile 
    850                 855                 860


Leu Asp Ser Ala Glu Phe Ile Lys Phe Thr Val Ile Arg Pro Phe Pro 
865                 870                 875                 880


Gly Leu Val Ile Asn Asn Gln Leu Val Asp Gln Ser Glu Ser Glu Gly 
                885                 890                 895


Pro Val Ile Gln Glu Ser Ala Glu Pro Ser Gln Leu Glu Val Pro Ala 
            900                 905                 910


Thr Glu Glu Ile Lys Glu Thr Asp Gly Ser Ser Gln Ile Lys Gln Glu 
        915                 920                 925


Pro Asp Pro Thr Trp 
    930



